TY - JOUR
AU - Etheridge, S.
AU - Deeds, J.
AU - Hall, S.
AU - White, K.
AU - Flewelling, L.
AU - Abbott, J.
AU - Landsverg, J.
AU - Conrad, S.
AU - Bodager, D.
AU - Jackrow, G.
TI - Detection methods and their limitations: PSP toxins in the southern puffer fish Sphoeroides nephelus responsible for human poisoning events in Florida in 2004
JO - African Journal of Marine Science
PY - 2006/01/01/
VL - 28
IS - 2
SP - 383
EP - 387
PB - NISC
SN - 02577615
AV - Document Delivery: ISAP Document Delivery: National Library of South Africa; Pta Div, PO Box 397, 0001 SOUTH AFRICA ; Tel: +27 12 321-8931 Fax: +27 12 325-5702; Email: docdel@nlsa.ac.za; URL: http://www.nlsa.ac.za/NLSA/index.html
N1 - Database Contributor: AFRICAN PUBLICATIONS; ISAP - INDEX TO SOUTH AFRICAN PERIODICALS; COMPOSITE RECORD. Database Contributor ID: 1618162; 614732. Database Subset: COMPOSITE RECORD; AFRICAN STUDIES; SOUTH AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article; Research article. Place of Publication: 19 Worcester Street, Grahamstown, South Africa. Conference: Proceedings of the 11th International Conference on Harmful Algae. Conference Date: 15-19 November 2004. Conference Location: Harmful Algae, Cape Town, South Africa. Accession Number: 1618162. Author Affiliation: [2006] - US Food and Drug Administration, 8301 Muirkirk Road, Laurel, Maryland 20708, USA 1;
AB - Demonstrates the steps required to confirm toxins by HPLC (high-performance liquid chromatography), provides a comparison of this method with others, and emphasises the continued threat of PFP (puffer fish poisoning) from puffers caught in the Titusville, Florida region
KW - Fish
KW - techniques / apparatus / gear / methods
KW - Toxicology / toxicity
KW - Algae
KW - Incertis
KW - Sedis
KW - Sphoeroides nephelus
KW - North America
KW - United States
KW - Florida
KW - Fish
KW - techniques / apparatus / gear / methods
KW - Toxicology / toxicity
KW - Algae
KW - North America
KW - United States
KW - Florida
KW - Incertis
KW - Sedis
KW - Sphoeroides nephelus
KW - detection methods
KW - High-performance liquid chromatography
KW - HPLC
KW - hplc [high performance liquid chromatography]
KW - human poisoning
KW - LCMs
KW - lcms [liquid chromatography mass spectrometry]
KW - Liquid chromatography mass spectrometry
KW - Paralytic shellfish poisoning
KW - PSP
KW - psp toxins
KW - psp [paralytic shellfish poisoning]
KW - puffer fish
KW - Puffer fish poisoning
KW - Saxitoxin
KW - saxitoxins
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1618162&site=ehost-live&scope=site
UR - www.nisc.co.za
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Kirman, Joanna R
AU - Turon, Tara
AU - Su, Hua
AU - Li, Amy
AU - Kraus, Carl
AU - Polo, John M
AU - Belisle, John
AU - Morris, Sheldon
AU - Seder, Robert A
TI - Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A
JO - Infection and Immunity
PY - 2003/01/01/
VL - 71
IS - 1
SP - 575
EP - 579
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00199567
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa; CAS Registry Number: 0; 0; 82115-62-6; EC Number: 2.3.-; 2.3.1.-; 2.7.7.48. Database Contributor: MEDLINE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: 12496215; 876887. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 12496215. Author Affiliation: 2003 Year - Vaccine Research Centre, 40 Convent Dr, Room 40/3512, NIH, Bethesda, MD 20892-3005, USA 1; Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Food and Drug Administration, Bethesda, Maryland 20892, USA 2;
AB - HEALTHLIT Abstract: The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector
KW - Physiology / Biology
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Biochemistry / molecular biology
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - Physiology / Biology
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Biochemistry / molecular biology
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - plasmid dna
KW - vaccines
KW - sindbis virus
KW - replicase functions
KW - gene expression
KW - antigens
KW - comparative studies
KW - dna vectors
KW - gene encoding
KW - immunogenicity
KW - mice
KW - disease resistance
KW - vector comparisons
KW - tuberculosis
KW - dosage
KW - cfu [colony forming units]
KW - lungs
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=12496215&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Wolf, R Cameron
AU - Bond, K C
TI - Exploring similarity between peer educators and their contacts and AIDS-protective behaviours in reproductive health programmes for adolescents and young adults in Ghana
JO - AIDS Care
PY - 2002/01/01/
VL - 14
IS - 3
SP - 361
EP - 373
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: cwolf@hrsa.gov; Contract Number: F31 MH11815/MH/NIMH NIH HHS. Database Contributor: MEDLINE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: 12075598; 968117. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 12075598. Author Affiliation: 2002 Year - Health Resources and Services Administration, Rockville, Maryland, USA 1; Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, Maryland 20857, USA 2;
AB - HEALTHLIT Abstract: This analysis explores the similarity between peer educators and their contacts. To examine interpersonal communication in the context of peer education, this study tested a new approach using multiple semi-structured interviews and network analysis to collect data from 106 peer educators and 526 of their contacts. These evaluation activities were conducted at three sites in Ghana during April 1998, in peri-urban and rural locations, and in in-school and out-of-school targeted settings. It was found that in their peer counselling and peer promotion activities peer educators tend to reach people who are like themselves (53% within 2 years of age, 59% same sex, 70% same ethnicity, and 65% same school status) however, this trend is not uniform among all youth and varies by demographic characteristics and their cultural environment. By examining the social networks of peer educators, it is possible to gain a better understanding of the process of peer education counselling in the context in which it occurs. The study also shows that controlling for other factors, contacts of peer educators who are highly similar regarding age, sex, ethnicity, and school status, are 1.74 times more likely (95% CI: 1.18, 2.56) to have done something to protect themselves from AIDS in the past three months. The results have relevance for programme managers and planners, researchers, and international agencies serving youth
KW - Education / information
KW - Health / public health
KW - Medical Science
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Africa
KW - Ghana
KW - Education / information
KW - Health / public health
KW - Medical Science
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Africa
KW - Ghana
KW - peer educators
KW - interpersonal communication
KW - peer education
KW - peri urban communities
KW - rural communities
KW - peer counselling
KW - peer promotion
KW - demographic characteristics
KW - school education promotions
KW - school status
KW - ethnicity
KW - cultural environments
KW - social networks
KW - peer education counselling
KW - age factors
KW - program management
KW - hiv [human immunodeficiency virus]
KW - aids [acquired immune deficiency syndrome]
KW - international agencies
KW - youth counselling
KW - youth programs
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=12075598&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Ellenberger, D L
AU - Hu, D J
AU - Wiktor, S Z
AU - Greenberg, A E
AU - Rayfield, M A
AU - Pieniazek, D.
AU - Nkengasong, J.
AU - Luo, C-C.
AU - Devare, S.
AU - Maurice, C.
AU - Janini, M.
AU - Ramos, A.
AU - Fridlund, C.
AU - Coulibaly, I-M.
AU - Ekpini, E.
AU - Schochetman, G.
TI - Genetic analysis of human immunodeficiency virus in Abidjan, Ivory Coast reveals predominance of HIV type 1 subtype A and introduction of subtype G
JO - AIDS Research and Human Retroviruses
PY - 1999/01/01/
VL - 15
IS - 1
SP - 3
EP - 9
PB - Mary Ann Liebert, Inc. Publishers: 140 Huguenot Street, 3rd Floor, New Rochelle, New York, 10801-5215, USA
SN - 08892229
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa; CAS Registry Number: 0; 0; EC Number: 3.4.23.-; E-mail: dxe1@cdc.gov. Database Contributor: MEDLINE; HEALTHLIT; AFRICAN DEVELOPMENT DATABASE; COMPOSITE RECORD. Database Contributor ID: 10024047; 923400. Database Subset: AFRICAN HEALTHLINE; AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 10024047. Author Affiliation: [1999] - HIV and Retrovirology Branch, Division of AIDS, STD and TB Laboratory Research (DASTLR), National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, 30333, USA 1; HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA 2; Locations: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa.
AB - AFRICAN DEVELOPMENT Abstract: To better understand the molecular epidemiology of HIV genetic diversity in Abidjan, Ivory Coast, we performed a genetic analysis of 170 HIV-1-seropositive specimens representing newly diagnosed tuberculosis patients (n = 143) and women monitored in a mother-to-child transmission cohort study (n = 27). Preliminary screening with RFLP presumptively classified 162 (95.3%) of these as subtype A. The envelope region of 108 specimens was subtyped by sequence analysis: 102 (94.4%) were subtype A, 2 (1.9%) were subtype D, and 4 (3.7%) were subtype G. Subtyping gag and env regions of the genome suggested that five of the six nonsubtype A isolates exhibited a potentially mosaic structure. A comparative phylogenetic analysis of HIV-1 subtype A C2V3 from 27 Ivory Coast and 21 Ugandan sequences revealed a striking clustering among Ivory Coast variants, and an independent segregation from Ugandan subtype A. Despite independent clustering with other subtype A specimens, limited variability of the V3 loop apex was observed; the globally predominant V3 motif, GPGQ, represented 90.1% of the HIV-1 strains. This study demonstrates that clade A is the predominant HIV-1 subtype in HIV-seropositive individuals in Abidjan, Ivory Coast and that these strains are phylogenetically distinct from other subtype A strains observed in East Africa
KW - Bacteria / Fungi / Viruses
KW - Biochemistry / Molecular biology
KW - Laboratory experiments
KW - Microbiology / Biotechnology
KW - Medical Science
KW - Genetics / Strains / Stock identification
KW - Africa
KW - Ivory Coast
KW - Bacteria / Fungi / Viruses
KW - Biochemistry / Molecular biology
KW - Laboratory experiments
KW - Microbiology / Biotechnology
KW - Medical Science
KW - Genetics / Strains / Stock identification
KW - Africa
KW - Ivory Coast
KW - hiv-1 subtypes
KW - hiv-1 subtype a
KW - hiv-1 [human immunodeficiency virus type 1]
KW - hiv seropositive individuals
KW - epidemiology
KW - genetic analyses
KW - hiv-1 subtype g
KW - independent clustering
KW - subtype a
KW - subtype g
KW - hiv subtypes
KW - subtype d
KW - phylogenetic analysis
KW - molecular epidemiology
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=10024047&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Mahajan, Babita
AU - Jani, Dewal
AU - Chattopadhyay, Rana
AU - Nagarkatti, Rana
AU - Zheng, Hong
AU - Majam, Victoria
AU - Weiss, Walter
AU - Kumar, Sanjai
AU - Rathore, Dharmendar
TI - Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domain
JO - Infection and Immunity
PY - 2005/01/01/
VL - 73
IS - 9
SP - 5402
EP - 5409
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00199567
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa; CAS Registry Number: 0; 0. Database Contributor: MEDLINE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: 16113256; 792248. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 16113256. Author Affiliation: 2005 Year - Aqua Research Lab, Department of Zoology, University of Delhi, Delhi-110007, India 1; Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India 2; Solid Waste Management Divisio, National Environmental Engineering Research Institute(NEERI), Nehru Marg, Nagpur - 440 020, Maharashtra, India 3; Bacterial and Parasitic Diseases Section, Division of Emergoing and Transfusion transmitted Diseases, Centre for Biologics Evaluation and Research, Food and Drug Admin, HFM-313, 1401 Rockville Pike, Rockville, Maryland 20852-1448, USA 4; Chemical Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, Uttaranchal, India 5; Department of Zoology, DSB Campus, Kumaun University, Naini Tal 263002, India 6; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA 7;
AB - HEALTHLIT Abstract: Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the partially completed genome sequence of the simian malaria parasite Plasmodium knowlesi, we have identified a 786-bp DNA sequence that encodes a 262-amino-acid-long protein, containing an altered version of the thrombospondin type I repeat domain (SPATR). Thrombospondin type 1 repeat domains participate in biologically diverse functions, such as cell attachment, mobility, proliferation, and extracellular protease activities. The SPATR from P. knowlesi (PkSPATR) shares 61% and 58% sequence identity with its Plasmodium falciparum and Plasmodium yoelii orthologs, respectively. By immunofluorescence analysis, we determined that PkSPATR is a multistage antigen that is expressed on the surface of P. knowlesi sporozoite and erythrocytic stage parasites. Recombinant PkSPATR produced in Escherichia coli binds to a human hepatoma cell line, HepG2, suggesting that PkSPATR is a parasite ligand that could be involved in sporozoite invasion of liver cells. Furthermore, recombinant PkSPATR reacted with pooled sera from P. knowlesi-infected rhesus monkeys, indicating that native PkSPATR is immunogenic during infection. Further efficacy evaluation studies in the P. knowlesi-rhesus monkey sporozoite challenge model will help to decide whether the SPATR molecule should be developed as a vaccine against human malarias
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Biochemistry / molecular biology
KW - Physiology / Biology
KW - Parasites
KW - Insertae
KW - Sedis
KW - Plasmodium knowlesi
KW - Insertae
KW - Sedis
KW - Plasmodium yoelii
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Biochemistry / molecular biology
KW - Physiology / Biology
KW - Parasites
KW - Insertae
KW - Sedis
KW - Plasmodium knowlesi
KW - Insertae
KW - Sedis
KW - Plasmodium yoelii
KW - identification
KW - cloning
KW - gene expression
KW - characterisation
KW - surface proteins
KW - malaria
KW - thrombospondin related adhesive proteins
KW - repeat sequences
KW - cell attachment
KW - extracelluar enzymes
KW - immunofluorescence [cill]
KW - sporozoites
KW - rhesus monkeys
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=16113256&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Mwinzi, P M N
AU - Karanja, D M S
AU - Secor, W Evan
AU - Shah, Amil
AU - Mwinzi, Pauline M N
AU - Ndenga, Bryson A
AU - Watta, Caroline O
AU - Karanja, Diana M S
TI - Increased density of human immunodeficiency virus type 1 coreceptors CCR5 and CXCR4 on the surfaces of CD4[+] T cells and monocytes of patients with Schistosoma mansoni infection
JO - Infection and Immunity
PY - 2003/01/01/
VL - 71
IS - 11
SP - 6668
EP - 6671
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00199567
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa; CAS Registry Number: 0; 0; E-mail: was4@cdc.gov. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 874565; 14573694. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 874565. Author Affiliation: 2003 Year - Immunology Branch, Division of Parasitic Diseases, Centres for Disease Control and Prevention, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA 1; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA 2;
AB - HEALTHLIT Abstract: Distribution of chemokine receptors CCRS and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4+ T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients
KW - Biochemistry / molecular biology
KW - Diseases / pathogens
KW - Health / public health
KW - Parasites
KW - Physiology / Biology
KW - Insertae
KW - Sedis
KW - Schistosoma mansoni
KW - Africa
KW - Kenya
KW - Biochemistry / molecular biology
KW - Diseases / pathogens
KW - Health / public health
KW - Parasites
KW - Physiology / Biology
KW - Africa
KW - Kenya
KW - Insertae
KW - Sedis
KW - Schistosoma mansoni
KW - cell invasions
KW - staining profiles [ill]
KW - antibodies
KW - stools
KW - survey
KW - disease prevalence
KW - kisumu
KW - gene expression
KW - chemokine receptors
KW - monocytes
KW - infections
KW - cell surfaces
KW - t cells
KW - co receptors
KW - hiv [human immunodeficiency virus]
KW - schistosomiasis
KW - cellular susceptibility
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=874565&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Sutherland, J.B.
AU - Freeman, J.P.
AU - Williams, A.J.
AU - Deck, J.
TI - Metabolism of cinnoline to N-oxidation products by Cunninghamella elegans and Aspergillus niger [Language: en]
JO - Journal of Industrial Microbiology and Biotechnology
PY - 1998/10/01/
VL - 21
IS - 4/5
SP - 225
EP - 227
SN - 13675435
AV - Location: *US (DNAL QR53.J68); Number: 1999005885
N1 - Database Contributor: AGRIS; COMPOSITE RECORD. Database Contributor ID: GB1999004400; US1999005885. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB1999004400. Author Affiliation: Deck, J. : National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 USA 1;
AB - Cultures of the fungi Cunninghamella elegans and Aspergillus niger were grown in fluid Sabouraud medium at 28 degrees C for 3 days and then dosed with cinnoline (1,2-diazanaphthalene). After 3 more days, metabolites were extracted from the cultures with ethyl acetate, separated by high-performance liquid chromatography, and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Both fungi oxidized 2-10% of the added cinnoline to mixtures of cinnoline 2-oxide and cinnoline 1-oxide
KW - agent pathogene
KW - aspergillus niger
KW - azote
KW - biodegradacion
KW - biodegradation
KW - chemical degradation
KW - chromatographie
KW - chromatography
KW - cinnoline
KW - contaminantes
KW - cromatografia
KW - culture techniques
KW - cunninghamella
KW - cunninghamella elegans
KW - degradacion
KW - degradation
KW - enfermedades fungosas
KW - enzimas
KW - enzyme
KW - enzymes
KW - espectrometria
KW - espectrometria de masas
KW - espectroscopia rmn
KW - fungal diseases
KW - maladie fongique
KW - mass spectrometry
KW - metabolism
KW - metabolisme
KW - metabolismo
KW - metabolite
KW - metabolites
KW - metabolitos
KW - nitrogen
KW - nitrogeno
KW - nmr spectroscopy
KW - organismos patogenos
KW - oxidacion
KW - oxidation
KW - oxydation
KW - pathogens
KW - polluant
KW - pollutants
KW - spectrometrie
KW - spectrometrie de masse
KW - spectrometry
KW - spectroscopie rmn
KW - technique de culture
KW - tecnicas de cultivo
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=GB1999004400&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Lim, J H
AU - Jeon, Bo Young
AU - Derrick, Steven C
AU - Lim, Jaehyun
AU - Kolibab, Kristopher
AU - Dheenadhayalan, Veerabadran
AU - Yang, Amy Li
AU - Kreiswirth, Barry
AU - Morris, Sheldon L
TI - Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice
JO - Infection and Immunity
PY - 2008/01/01/
VL - 76
IS - 11
SP - 5173
EP - 5180
PB - American Society for Microbiology: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00199567
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa; CAS Registry Number: 0. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 1050377; 18710860. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1050377. Author Affiliation: 2005 Year - Centre for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA 1; Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA 2;
AB - HEALTHLIT Abstract: Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective responses in a marine model of pulmonary tuberculosis, C57BL/6 mice were vaccinated with BCG vaccine and then challenged 2 months later with one of nine M. tuberculosis isolates. Four of these strains were from the W-Beijing lineage (HN878, N4, NHN5, and ChS) while four were non-Beijing-type isolates (C913, CDC1551, NY669, and NY920). As a control, the WHO standard M. tuberculosis Erdman strain was evaluated in these vaccination/challenge experiments. To assess the protective responses evoked by BCG immunization, organ bacterial burdens and lung pathology were assessed in vaccinated and naive mice at 4, 12, and 20 weeks postchallenge as well as during the day of infection. At 4 weeks after the aerosol challenge with each of these strains, significantly reduced bacterial growth in the lungs and spleens and significantly improved lung pathology were seen in all vaccinated animals compared to naive controls. After 12 weeks, reduced organ bacterial burdens were detected in vaccinated animals infected with six of nine challenge strains. Although lung CFU values were lower in vaccinated mice for only three of nine groups at 20 weeks postchallenge, significantly decreased lung inflammation was seen in all immunized animals relative to controls at 20 weeks postchallenge. Taken together, these data demonstrate that BCG vaccination protects against infection with diverse M. tuberculosis strains in the mouse model of pulmonary tuberculosis and suggest that strain-specific resistance to BCG-induced protective immunity may be uncommon
KW - Genetics / Strains / Stock identification
KW - Biochemistry / Molecular biology
KW - Physiology / Biology
KW - Humans
KW - Mammals
KW - Microbiology / Biotechnology
KW - Diseases / Pathogens
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - Genetics / Strains / Stock identification
KW - Biochemistry / Molecular biology
KW - Physiology / Biology
KW - Humans
KW - Mammals
KW - Microbiology / Biotechnology
KW - Diseases / Pathogens
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - bcg vaccines
KW - protective immunity
KW - strain specific resistance
KW - disease burdens
KW - pulmonary tuberculosis
KW - cfu [colony forming units]
KW - comparative studies
KW - post challenge tests
KW - mice
KW - strains
KW - detection
KW - immunisation
KW - genotypes
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1050377&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Parra, Marcela
AU - Cadieux, Nathalie
AU - Pickett, Thames
AU - Dheenadhayalan, Veerabadran
AU - Brennan, Michael J
TI - A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen
JO - Infection and Immunity
PY - 2006/01/01/
VL - 74
IS - 1
SP - 786
EP - 789
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00199567
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa; CAS Registry Number: 0; 0. Database Contributor: MEDLINE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: 16369041; 794628. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 16369041. Author Affiliation: 2006 Year - Office of Vaccines research and review, Center for Biologics Evaluation and research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892 1; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA 2;
AB - HEALTHLIT Abstract: Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes
KW - Biochemistry / molecular biology
KW - Physiology / Biology
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Insertae
KW - Sedis
KW - Mycobacterium avium
KW - Biochemistry / molecular biology
KW - Physiology / Biology
KW - Diseases / pathogens
KW - Microbiology / biotechnology
KW - Insertae
KW - Sedis
KW - Mycobacterium avium
KW - immunisation
KW - elisa [enzyme linked immunosorbent assays]
KW - ifn gamma [gamma interferon]
KW - agarose gel electrophoresis
KW - antigens
KW - pgrs [polymorphic glycine repeat sequences]
KW - previously exposed proteins
KW - mape dna
KW - novel genes
KW - immune responses
KW - t cells
KW - gene expression
KW - previously exposed genes
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=16369041&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - McNamara, P
TI - Purchaser strategies to influence quality of care: from rhetoric to global applications
JO - Quality and Safety in Health Care
PY - 2006/01/01/
VL - 15
IS - 3
SP - 171
PB - British Medical Journal: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN - 14753898
N1 - Note: E-mail: pmcnamar@ahrq.gov. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 1169359; 16751465. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1169359. Author Affiliation: 2006 Year - Senior Policy Analyst, Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA 1; Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA 2;
AB - HEALTHLIT Abstract: The potential of purchasers to influence the quality and safety of care has captured the attention of health sector leaders worldwide. Quality based purchasing explicitly seeks to hold providers accountable for the quality and safety of care. Three strategies are available to purchasers: (1) selective contracting based on quality; (2) payment differentials based on quality; and (3) sponsorship of comparative provider report cards. Examples are given to illustrate each of the three strategies. Governments, employers, social insurance funds, community based insurance organizations, health plans, donors, and other buyers of health services are encouraged to explore and debate these purchaser strategies within the context of an overarching national or local quality framework. Public and private funders of operations research are encouraged to support and disseminate evaluations of purchaser efforts to improve quality. This paper is designed to highlight and frame purchasers' strategies explicitly crafted to enhance the quality and safety of care. The ultimate aim is to encourage thoughtful discussion about whether or not one or more purchaser strategy might support a particular country's goals to improve care. Experiences from both developed and developing countries are included to facilitate the exchange of ideas and provide the broadest of perspectives
KW - Health / Public health
KW - Medical Science
KW - Health / Public health
KW - Medical Science
KW - purchasing
KW - strategies
KW - quality
KW - performance
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1169359&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - van Hest, N A H
AU - Story, A
AU - Grant, A D
AU - Antoine, D
AU - Crofts, J P
AU - Watson, J M
TI - Record-linkage and capture-recapture analysis to estimate the incidence and completeness of reporting of tuberculosis in England 1999-2002
JO - Epidemiology and Infection
PY - 2008/01/01/
VL - 136
IS - 12
SP - 1606
SN - 09502688
N1 - Note: E-mail: vanhestr@ggd.rotterdam.nl. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 1148181; 18346285. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1148181. Author Affiliation: 2008 Year - Tuberculosis Control Section, Division of Infectious Diseas Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, The Netherlands 1; Tuberculosis Control Section, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands 2;
AB - HEALTHLIT Abstract: In 1999 the Enhanced Tuberculosis Surveillance (ETS) system was introduced in the United Kingdom to strengthen surveillance of tuberculosis (TB). The aim of this study was to assess the use of record-linkage and capture-recapture methodology for estimating the completeness of TB reporting in England between 1999 and 2002. Due to the size of the TB data sources sophisticated record-linkage software was required and the proportion of false-positive cases among unlinked hospital-derived TB records was estimated through a population mixture model. This study showed that record-linkage of TB data sources and cross-validation with additional TB-related datasets improved data quality as well as case ascertainment. Since the introduction of ETS observed completeness of notification in England has increased and the results were consistent with expected levels of under-notification. Completeness of notification estimated by a log-linear capture-recapture model was highly inconsistent with prior estimates and the validity of this methodology was further examined
KW - Humans
KW - Health / Public health
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - Humans
KW - Health / Public health
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - tuberculosis infections
KW - capture recapture data
KW - record linkage
KW - ets [enhanced tubercuolsis system]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1148181&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Osuide, G.E.
TI - Regulatory aspects of functional foods in Nigeria [Language: en]
JO - Nutrition Reviews
PY - 1996/11/01/
VL - 54
IS - 11 Pt 2
SP - SS167
EP - SS167
SN - 00296643
AV - Location: *US (DNAL 389.8 N953); Number: 1997065393
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: AGRIS; MEDLINE; COMPOSITE RECORD. Database Contributor ID: US1997065393; 9110597. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US1997065393. Author Affiliation: National Agency for Food and Drug Administration and Control (NAFDAC) of Nigeria 1;
KW - nigeria
KW - foods
KW - regulations
KW - produit alimentaire
KW - reglementation
KW - alimentos
KW - reglamentaciones
KW - neutraceuticals
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=US1997065393&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - de Vries, G
AU - Baars, H W M
AU - van Hest, N A H
AU - Richardus, J H
AU - Sebek, M M G G
TI - Transmission classification model to determine place and time of infection of tuberculosis cases in an urban area
JO - Journal of Clinical Microbiology
PY - 2008/01/01/
VL - 46
IS - 12
SP - 3924
EP - 3930
PB - American Society for Microbiology: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00951137
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: devriesg@ggd.rotterdam.nl. Database Contributor: HEALTHLIT; MEDLINE; COMPOSITE RECORD. Database Contributor ID: 1149073; 18842933. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1149073. Author Affiliation: 2008 Year - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, The Netherlands 2008 Year - Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands 1; Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands 2;
AB - HEALTHLIT Abstract: We conducted a population-based study in the Rotterdam region of The Netherlands to determine the place and time of infection of tuberculosis (TB) cases using conventional epidemiological and genotyping information. In particular, we focused on the extent of misclassification if genotyping was not combined with epidemiological information. Cases were divided into those with a unique mycobacterial DNA fingerprint, a clustering fingerprint, and an unknown fingerprint. We developed transmission classification trees for each category to determine whether patients were infected in a foreign country or recently (<= 2 years) or remotely (> 2 years) infected in The Netherlands. Of all TB cases during the 12-year study period, 38% were infected in a foreign country, 36% resulted from recent transmission in The Netherlands, and 18% resulted from remote infection in The Netherlands, while in the remaining cases (9%) either the time or place of infection could not be determined. The conventional epidemiological data suggested that at least 29% of clustered cases were not part of recent chains of transmission. Cases with unknown fingerprints, almost all culture negative, relatively frequently had confirmed epidemiological links with a recent pulmonary TB case in The Netherlands and were more often identified by contact tracing. Our findings highlight the idea that genotyping should be combined with conventional epidemiological investigation to establish the place and time of infection of TB cases as accurately as possible. A standardized way of classifying TB into recently, remotely, and foreign-acquired disease provides indicators for surveillance and TB control program performance that can be used to decide on interventions and allocation of resources
KW - Diseases / Pathogens
KW - Taxonomy / Systematics / Classification
KW - Medical Science
KW - Biochemistry / Molecular biology
KW - Genetics / Strains / Stock identification
KW - Bacteria / Fungi / Viruses
KW - Health / Public health
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - Europe
KW - Netherlands
KW - Diseases / Pathogens
KW - Taxonomy / Systematics / Classification
KW - Medical Science
KW - Biochemistry / Molecular biology
KW - Genetics / Strains / Stock identification
KW - Bacteria / Fungi / Viruses
KW - Health / Public health
KW - Europe
KW - Netherlands
KW - Insertae
KW - Sedis
KW - Mycobacterium tuberculosis
KW - genotyping
KW - infection time
KW - infection place
KW - epidemiology
KW - rotterdam
KW - tb [tuberculosis]
KW - south holland province
KW - transmission classification
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Strosnider, Heather
AU - Azziz-Baumgartner, Eduardo
AU - Banziger, Marianne
AU - Bhat, Ramesh V
AU - Breiman, Robert
AU - Brune, Marie-Noel
AU - DeCock, Kevin
AU - Dilley, Abby
AU - Groopman, John
AU - Hell, Kerstin
AU - Henry, Sara H
AU - Jeffers, Daniel
AU - Jolly, Curtis
AU - Jolly, Pauline
AU - Kibata, Gilbert N
AU - Lewis, Lauren
AU - Liu, Xiumei
AU - Luber, George
AU - McCoy, Leslie
AU - Mensah, Patience
AU - Miraglia, Marina
AU - Misore, Ambrose
AU - Njapau, Henry
AU - Ong, Choon-Nam
AU - Onsongo, Mary T K
AU - Page, Samuel W
AU - Park, Douglas
AU - Patel, Manish
AU - Phillips, Timothy
AU - Pineiro, Maya
AU - Pronczuk, Jenny
AU - Rogers, Helen Schurz
AU - Rubin, Carol
AU - Sabino, Myrna
AU - Schaafsma, Arthur
AU - Shephard, Gordon
AU - Stroka, Joerg
AU - Wild, Christopher
AU - Williams, Jonathan T
AU - Wilson, David
AU - Onsongo, M. T.
TI - Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries
JO - Environmental Health Perspectives
PY - 2006/12/01/
VL - 114
IS - 12
SP - 1898
EP - 1903
PB - National Institute of Environmental Health Sciences
SN - 00916765
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: hks9@dc.gov. Database Contributor: MEDLINE; SAMED; COMPOSITE RECORD. Database Contributor ID: 17185282; 060041. Database Subset: AFRICAN HEALTHLINE. Corporate Author: Programme on Mycotoxins and Experimental Carcinogenesis. Language: English. Document Type: Article. Publication Type: Journal Article. Place of Publication: Western Cape. Accession Number: 17185282. Author Affiliation: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3717, USA, , International Maize and Wheat Improvement Center, Nairobi, Kenya, Centre for Science Society and Culture,,Indian Council of Medical Research, Hyderabad, India, Kenya Medical Research Institute, Centers for Disease Control and Prevention, Nairobi, Kenya, World Health Orgnaization, Geneva, Switzerland, Centers for Disease Control and Prevention, Kenya Office, Nairobi, Kenya, Resolve, Washington, DC, USA, John Hopkins Bloomberg School of Oublic Health, Baltimore, Maryland, USA, Biological Control Center for Africa, International Insitute of Tropical Agriculture, Cotonou, Benin, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA, International Maize and Wheat Improvement Center, Mexico City, Mexico, Department of Agricultural Economics and Rural Sociology, Auburn University, Auburn, Alabama, USA, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA, Kenya Agricultural Research Institute, Nairobi, Kenya, Institute of Nutrition and Food Safety, Chinese Center for DiseaseControl and Prevention, Beijing, China, World Health Organization, Regional Office for Africa, Brazaville, Republic of Congo, Center for Food Risk Assessment and Quality, Instituto Superiore di Sanita, Rome, Italy, Preventive and Promotive Health, Kenya Ministry of Health, Agricultural Service, U.S. Department of Agriculture, Nairobi, Kenya, Center for Food Safety, Texas A&M University, College Station, Texas, USA, Food Quality and Standards Service, Food and Agriculture Organization, Rome, Italy, Instituto Adolfo Lutz, Sao Paulo, Brazil, Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, P.O. Box 19070, Tygerberg, South Africa 1;
AB - MEDLINE Abstract: Consecutive outbreaks of acute aflatoxicosis in Kenya in 2004 and 2005 caused > 150 deaths. In response, the Centers for Disease Control and Prevention and the World Health Organization convened a workgroup of international experts and health officials in Geneva, Switzerland, in July 2005. After discussions concerning what is known about aflatoxins, the workgroup identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies. The workgroup also identified public health strategies that could be integrated with current agricultural approaches to resolve gaps in current knowledge and ultimately reduce morbidity and mortality associated with the consumption of aflatoxin-contaminated food in the developing world. Four issues that warrant immediate attention were identified: a) quantify the human health impacts and the burden of disease due to aflatoxin exposure; b) compile an inventory, evaluate the efficacy, and disseminate results of ongoing intervention strategies; c) develop and augment the disease surveillance, food monitoring, laboratory, and public health response capacity of affected regions; and d) develop a response protocol that can be used in the event of an outbreak of acute aflatoxicosis. This report expands on the workgroup's discussions concerning aflatoxin in developing countries and summarizes the findings
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Weiss, Cd.
TI - HIV-1 gp41: Mediator of fusion and target for inhibition
JO - Aids Reviews
PY - 2003/01/01/
VL - 5
IS - 4
SP - 214
EP - 221
PB - Permanyer Publications: Mallorca, 310, Barcelona - Spain
SN - 11396121
N1 - Note: HEALTHLIT Location: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. Database Contributor: AFRICAN DEVELOPMENT DATABASE; HEALTHLIT; COMPOSITE RECORD. Database Contributor ID: 923325-1. Database Subset: AFRICAN STUDIES; AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 923325-1. Author Affiliation: [2003] - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 1; Locations: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa.
AB - AFRICAN DEVELOPMENT Abstract: The bipartite envelope glycoprotein (Env) of the human immunodeficiency virus type 1 (HIV-1) performs two essential functions for initiating virus infection. The gp120 surface subunit of Env binds cell receptors to attach virus to target cells and regulate viral entry. The gp41 transmembrane subunit fuses host-cell and viral membranes to deliver the viral core into the cell cytoplasm. The two subunits derive from a polyprotein precursor, gp160. Cleavage of gp160 in the biosynthetic pathway creates mature Env consisting of the noncovalentlyassociated gp120/gp41 that is primed for viral entry. While performing distinct operations in HIV entry, the activities of the gp120 and gp41 subunits must be highly coordinated in order to lead to successful infection. This review highlights structure-function relationships in Env, with a focus on the heptadrepeat regions in the ectodomain of gp41. The mechanism of Env-mediated membrane fusion and ways to interfere with this process using inhibitors and antibodies that target gp41 are discussed
KW - Biochemistry / molecular biology
KW - Laboratory experiments
KW - Medical Science
KW - Microbiology / biotechnology
KW - Bacteria / fungi / viruses
KW - Genetics / strains / stock identification
KW - Illustrations
KW - Health / public health
KW - North America
KW - United States
KW - Maryland
KW - Biochemistry / molecular biology
KW - Laboratory experiments
KW - Medical Science
KW - Microbiology / biotechnology
KW - Bacteria / fungi / viruses
KW - Genetics / strains / stock identification
KW - Illustrations
KW - Health / public health
KW - North America
KW - United States
KW - Maryland
KW - fusion proteins
KW - gp41
KW - membrane fusion
KW - bipartite envelope glycoprotein
KW - antibodies
KW - protease inhibitors
KW - hiv-1 [human immunodeficiency virus type 1]
KW - virus infection
KW - infection initiation
KW - hiv-1 infection
KW - viral entry
KW - structure-function relationships
KW - fusion inhibitors
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=923325-1&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - CHAP
AU - Brennan, M.J.
AU - Van Pittius, N.C.G.
AU - Espitia, C.
TI - The PE and PPE multigene families of mycobacteria
JO - Tuberculosis and the Tubercle Bacillus
PY - 2005/01/01/
PB - ASM Press
N1 - Database Contributor: SAMED; COMPOSITE RECORD. Database Contributor ID: 050064-2. Database Subset: AFRICAN HEALTHLINE. Corporate Author: Centre for Molecular and Cellular Biology. Document Type: Book Entry. Publication Type: Book Chapter. Place of Publication: Western Cape. Accession Number: 050064-2. Author Affiliation: Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, Medical Research Council and University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Centre for Biologics Evaluation and Research, Food and Drug Administration, United States 1;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=050064-2&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
AU - Cornelius, L J
TI - Access to medical care for black Americans with an episode of illness
JO - National Medical Association. Journal
PY - 1991/01/01/
VL - 83
IS - 7
SP - 617
EP - 626
SN - 00279684
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1920519. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1920519. Author Affiliation: US Department of Health and Human Services, Agency for Health Care Policy and Research, Rockville, MD 20857 1;
AB - MEDLINE Abstract: Blacks have been directly or indirectly affected by changes in policies such as cutbacks in the Medicaid program or decreases in the funding of graduate medical education. Yet there is considerable disagreement over whether blacks have achieved equity of access to medical care. Descriptive and multivariate regression analyses were conducted to examine the use of ambulatory and inpatient medical care by 1150 whites and blacks under the age of 65 who experienced an episode of illness and lived around sites serviced by the Community Hospital Program, which was developed to increase primary care in underserved communities. After controlling for demographic factors, health status, and aspects of the usual source of care, multivariate analyses revealed that race was not a determinant of differences found in the use of ambulatory and inpatient medical care or the likelihood that an individual was cured of the condition causing him or her the most worry. Differences in the use of care for blacks were believed to have occurred because blacks were disproportionately found in groups that used less medical care, ie, low-income groups, the uninsured, and those without a usual source of care
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Njapau, H.
TI - Acute jaundice outbreaks in Kenya and aflatoxin [Language: en]
JO - Journal of Kasetsart Veterinarians [Thailand]
PY - 2006/01/01/
SN - 01255169
AV - Location: Thai National AGRIS Centre, Office of The University Library Kasetsart University, P.O. BOX 1084 Kasetsart Chatuchak, Bangkok 10903.; Number: TAB000125510223
N1 - Database Contributor: AGRIS. Database Contributor ID: TH2008000912. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: TH2008000912. Author Affiliation: Center for Food Safety and Applied Nutrition, Maryland USA . U.S. Food and Drug Administration 1;
KW - maize
KW - aflatoxins
KW - mycotoxins
KW - contamination
KW - jaundice
KW - kenya
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=TH2008000912&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Zhan, C
AU - Miller, M R
TI - Administrative data based patient safety research: a critical review
JO - Quality and Safety in Health Care
PY - 2003/01/01/
VL - 12
IS - 6
SP - ii58
EP - iiii63
PB - British Medical Journal: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN - 14753898
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 1169641. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1169641. Author Affiliation: 2003 Year - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20852, USA 1;
AB - HEALTHLIT Abstract: Administrative data are readily available, inexpensive, computer readable, and cover large populations. Despite coding irregularities and limited clinical details, administrative data supplemented by tools such as the Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs) could serve as a screen for potential patient safety problems that merit further investigation, offer valuable insights into adverse impacts and risks of medical errors and, to some extent, provide benchmarks for tracking progress in patient safety efforts at local, state, or national levels
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - medical errors
KW - risks
KW - ahrq [agency for healthcare research and quality]
KW - psis [patient safety indicators]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=1169641&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - DEPAOLA, A
AU - Nordstrom, J L
AU - DALSGAARD, A
AU - Forslund, A
AU - OLIVER, J
AU - Bates, T
AU - Bourdage, K L
AU - Gulig, P A
TI - Analysis of Vibrio vulnificus from market oysters and septicemia cases for virulence markers
JO - Applied and Environmental Microbiology
PY - 2003/01/01/
VL - 69
IS - 7
SP - 4006
EP - 4011
PB - American Society for Microbiology [ASM]: 1752 N St., NW, Washington, DC 20036-2904, USA
SN - 00992240
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 254637. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 254637. Author Affiliation: [1995-2003] - U.S. Food and Drug Administration, Guld Coast Seafood Laboratory Post Office Box 158, Dauphin Island, Alabama 36528, USA 1; Fishery Research Branch, Food and Drug Administration, P.O. Box 158, Dauphin Island, Alabama 36528 2;
AB - HEALTHLIT Abstract: Representative encapsulated strains of Vibrio vulnificus from market oysters and oyster-associated primary septicemia cases (25 isolates each) were tested in a blinded fashion for potential virulence markers that may distinguish strains from these two sources. These isolates were analyzed for plasmid content, for the presence of a 460-bp amplicon by randomly amplified polymorphic DNA PCR, and for virulence in subcutaneously (s.c.) inoculated, iron-dextran-treated mice. Similar percentages of market oyster and clinical isolates possessed detectable plasmids (24 and 36%, respectively), produced the 460-bp amplicon (45 and 50%, respectively), and were judged to be virulent in the mouse s.c. inoculation-iron-dextran model (88% for each). Therefore, it appears that nearly all V. vulnificus strains in oysters are virulent and that genetic tests for plasmids and specific PCR size amplicons cannot distinguish between fully virulent and less virulent strains or between clinical and environmental isolates. The inability of these methods to distinguish food and clinical V. vulnificus isolates demonstrates the need for alternative subtyping approaches and virulence assays
KW - diseases / pathogens
KW - bacteria / fungi / viruses
KW - health / public health
KW - Vibrionaceae
KW - Vibrio vulnificus
KW - diseases / pathogens
KW - bacteria / fungi / viruses
KW - health / public health
KW - Vibrionaceae
KW - Vibrio vulnificus
KW - human health
KW - public health
KW - human food
KW - oysters
KW - human diseases
KW - septicemia
KW - molecular analsyis
KW - molecular marker
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DP - EBSCOhost
DB - awn
ER -
AU - Roehrig, John T
TI - Antigenic structure of flavivirus proteins
JO - Advances in Virus Research
PY - 2003/01/01/
VL - 59
SP - 141
EP - 175
SN - 00653527
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 14696329. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 14696329. Author Affiliation: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80521, USA 1;
AB - MEDLINE Abstract: The increased activity of Dengue virus in the tropical regions of the world and the recent movement of West Nile virus from the eastern to the western hemisphere emphasize the fact that vector-borne flaviviruses are medically important emerging infectious diseases. These facts warrant continued efforts to decode all facets of flavivirus immunology. This chapter reviews current understanding of the antigenic fine structure of flaviviral structural and nonstructural (NS) proteins and their involvement in B- an T-cell host responses. The virion structural glycoprotein E elicits both virus-neutralizing antibodies and antiviral Th-cell responses. Consistent with the current hypothesis of the MHC class I pathway of protein processing, immunodominant flaviviral Tc-cell epitopes mainly reside on the NS proteins. To prepare effective and inexpensive subunit vaccines, we will need to continue to better understand these structure-function relationships of flavivirus proteins
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Ashman, JJ.
AU - Conviser, R.
AU - Pounds, MB.
TI - Associations between HIV-positive individuals' receipt of ancillary services and medical care receipt and retention
JO - AIDS Care
PY - 2002/01/01/
VL - 14
IS - Supplement 1
SP - 109
EP - 118
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 968172. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 968172. Author Affiliation: 2002 Year - Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, USA 1;
AB - HEALTHLIT Abstract: This study examines associations between HIV-positive individuals' receipt of ancillary services and their receipt of and retention in primary medical care. Ancillary care services examined include case management, mental health and substance abuse treatment/counseling, advocacy, respite and buddy/companion services, as well as food, housing, emergency financial assistance, and transportation. The selection criterion used was the receipt of care from January-June 1997 at selected facilities receiving funding under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act, a federally funded safety net programme in the USA. The receipt of each ancillary service was associated with the receipt of any primary medical care from a safety net provider. All ancillary services were more strongly associated with primary care receipt than with retention in care or the mean number of primary care visits per year. Mental health and substance abuse treatment/counselling, client advocacy, respite care and buddy/companion services all had significant associations with all primary medical care measures. This is the first time in one study that the primary medical and ancillary services received by all clients at safety net-funded providers from multiple cities and states have been examined. All types of safety net providers, from the largest medical centre to the smallest community-based organization, are represented in this study. The patterns seen here are similar to the findings from the other, geographically more restricted, studies reported on in this volume
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Behaviour / psychology
KW - Health / public health
KW - Medical Science
KW - North America
KW - United States
KW - Maryland
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Behaviour / psychology
KW - Health / public health
KW - Medical Science
KW - North America
KW - United States
KW - Maryland
KW - hiv [human immunodeficiency virus]
KW - hiv care
KW - ancillary care services
KW - primary care
KW - ryan white care act
KW - substance abuse
KW - drug abuse counselling
KW - client advocacy
KW - respite care
KW - companion services
KW - medical care
KW - hiv clinics
KW - case management
KW - mental health
KW - mental health treatment
KW - substance abuse treatment
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Conviser, R.
AU - Pounds, MB.
TI - Background for the studies on ancillary services and primary care use
JO - AIDS Care
PY - 2002/01/01/
VL - 14
IS - Supplement 1
SP - 7
EP - 14
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 968164. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 968164. Author Affiliation: 2002 Year - Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, USA 1;
AB - HEALTHLIT Abstract: Timely and optimal HIV primary care is a key tenet of the Ryan White CARE Act, a safety net programme for vulnerable and marginalized people living with HIV in the USA. Health services researchers, local providers and policy makers suspect that ancillary services are necessary to improve entry into and retention in HIV primary care for vulnerable populations experiencing barriers to HIV services, including access to antiretroviral therapies. This paper provides background to the eight studies featured in this special supplement to AIDS Care . The eight studies examine retrospectively ancillary (support) services data collected after 1996 in six HIV epicenters (New York and Chicago, plus four sites included in the Client Demonstration project-Los Angeles, San Francisco, Orange County [California] and Washington, DC), three smaller hard-hit cities (Boston, New Orleans and St Louis) and several states (California, plus Michigan and Virginia from the Client Demonstration Projects). These varied delivery settings serve racial and ethnic minority populations, men who have sex with men, injection drug users, women and mothers. The studies use a range of analytic approaches to understand whether receipt of certain enabling services correlated with early entry into and retention in care. Ancillary services (support services such as case management, housing, food, transportation, mental health and substance abuse treatment) are used by local HIV medical and community-based organizations in facilitative strategies directed to populations that have difficulty entering or staying in HIV primary care. Understanding the contribution of ancillary services to timely entry into and consistent use of primary care, including the expanding range of HIV therapeutics, is important to service delivery system planners and resource allocation decision-makers
KW - Bacteria / fungi / viruses
KW - Sociology
KW - Health / public health
KW - Medical Science
KW - Policy / Management
KW - North America
KW - United States
KW - Bacteria / fungi / viruses
KW - Sociology
KW - Health / public health
KW - Medical Science
KW - Policy / Management
KW - North America
KW - United States
KW - ryan white care act
KW - primary care
KW - safety net program
KW - marginalised people
KW - hiv [human immunodeficiency virus]
KW - health services
KW - policy makers
KW - hiv epidemic
KW - hiv epicenters
KW - hiv primary care
KW - hiv care
KW - antiretroviral therapies
KW - support services data
KW - racial minorities
KW - ethnic minority
KW - minority populations
KW - injecting drug users
KW - gay men
KW - bisexual men
KW - heterosexuals
KW - ancillary care services
KW - hiv medical care
KW - hiv organisations
KW - hiv therapeutics
KW - delivery systems
KW - resource allocationtal health needs
KW - mental healthl factors
KW - sexual sensation seeking
KW - depression
KW - drug use
KW - substance abuseal aspects
KW - child care
KW - ethnic backgroundstherapynal supportol abuse
KW - nonsexual abuseyxophyceae microcystis aeruginosa
KW - +insertae sedis daphnia spp.
KW - +branchiopoda artemia salina
KW - +corbiculidae corbicula sandai
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Parham, D.
AU - Conviser, R.
TI - A brief history of the Ryan White CARE Act in the USA and its implications for other countries
JO - AIDS Care
PY - 2002/01/01/
VL - 14
IS - Supplement 1
SP - 3
EP - 6
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 968163. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 968163. Author Affiliation: 2002 Year - HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, USA 1;
AB - HEALTHLIT Abstract: The Ryan White CARE (Comprehensive AIDS Resource Emergency) Act was originally signed August 18, 1990, as a federal program designed to improve the quality and availability of care for persons with HIV/AIDS and their families. The Act was amended and reauthorized in May 1996 with four years of funding at levels determined annually as part of the federal budget process. The Program is administered by the Health Resources and Services Administration (HRSA) which is within the U.S. Department of Health and Human Services (DHHS). This article gives a brief overview of the history of the Ryan White Care Act in the US and discusses the future implications of this act in other countries
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Health / public health
KW - Medical Science
KW - History
KW - North America
KW - United States
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Health / public health
KW - Medical Science
KW - History
KW - North America
KW - United States
KW - primary care
KW - ryan white care act
KW - ryan white history
KW - aids care
KW - hiv [human immunodeficiency virus]
KW - hiv/aids
KW - federal program
KW - local expenditure
KW - federal funding
KW - hiv care
KW - family support
KW - hiv infected people
KW - hiv infected families
KW - social applications
KW - social support
KW - government support
KW - hiv research
KW - hiv funding
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Sudre, P.
AU - Serdula, M.
AU - Binkin, N.
AU - Staehling, N.
AU - Kramer, M.
TI - Child fostering, health and nutritional status: the experience of Swaziland [Language: en]
JO - Ecology of Food and Nutrition
PY - 1990/01/01/
VL - 24
IS - 3
SP - 181
EP - 188
SN - 03670244
AV - Location: GB; Number: 9112575
N1 - Database Contributor: AGRIS. Database Contributor ID: GB9112575. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: GB9112575. Author Affiliation: Kramer, M. : Division of Nutrition, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA USA 1;
KW - children
KW - nutritional status
KW - swaziland
KW - enfant
KW - etat nutritionnel
KW - ninos
KW - estado nutricional
KW - swazilandia
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DP - EBSCOhost
DB - awn
ER -
AU - El-Bouri, Kw
TI - Clinical Microbiology Services are Essential for Diagnosis, Treatment and Prevention of MRSA and other Nosocomial Pathogens in Libyan Healthcare Facilities
JO - The Libyan journal of medicine
PY - 2009/01/01/
VL - 4
IS - 3
SP - 91
EP - 92
SN - 19932820
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 21483518. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 21483518. Author Affiliation: National Public Health Service Swansea Microbiology Laboratories, Singleton Hospital, Sketty Lane, Swansea, UK 1;
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DP - EBSCOhost
DB - awn
ER -
AU - Walker, Richard I
TI - Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries
JO - Vaccine
PY - 2005/01/01/
VL - 23
IS - 26
SP - 3369
EP - 3385
SN - 0264410X
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: walkerri@cber.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 15837361. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15837361. Author Affiliation: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA 1;
AB - MEDLINE Abstract: Enteric pathogens constitute a major pediatric threat in the developing world through their impact on morbidity and mortality, physical and cognitive development and cause and effect relationship with malnutrition. Although many bacterial pathogens can cause diarrheal diseases, a group of less than 10 including Shigella spp., enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae, and possibly, Campylobacter jejuni account for a significant percentage of these diseases in developing countries. Rotavirus is also a major cause of diarrheal diseases. Vaccines against these agents offer a potentially effective control measure against these diseases, but safe, practical, and effective vaccines for many of these agents have yet to be realized. Many vaccine development approaches are under investigation, but the one that is currently most advanced and that has been most widely applied to enteric pathogens is the use of orally administered live or killed whole pathogen preparations. If inactivated, these vaccines will probably be administered as multiple doses with approximately 10(10) to 10(11) total particles per dose, but they are relatively safe for oral administration. Further, they may not require a buffer for delivery and can be stored in liquid formulations. Fewer doses may be required for some live attenuated pathogen vaccines, but a buffer will most likely be required for oral delivery and the product must be stored in a dried formulation. Also, safety becomes more of a concern with live pathogens depending on the degree of attenuation, host immunocompetence, and the total number and kinds of attenuated pathogens which may be present in a combined agent vaccine. Both live and killed whole pathogen vaccines can be immunogenic and have the possibility to serve as vectors for other antigens. Although many organisms and serotypes are clinically important, by exploiting antigenic cross reactivity and using some pathogen components as vectors for cloned antigens of other pathogens, it could be possible to induce immunity against major enteric pathogens/serotypes with <10 whole pathogen components in a multi-agent vaccine. Safe and effective mucosal adjuvants may in the future be useful in whole pathogen vaccines, but they do not seem to be essential for immunization. Further, dietary supplements such as zinc, mixed routes of delivery and new regimens are under study which may in the future enhance further the effectiveness of the whole path...
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DP - EBSCOhost
DB - awn
ER -
AU - Morens, David M
TI - Dengue fever and dengue hemorrhagic fever
JO - The Pediatric Infectious Disease Journal
PY - 2009/01/01/
VL - 28
IS - 7
SP - 635
EP - 636
SN - 08913668
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 19561427. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 19561427. Author Affiliation: Office of the Director, CAPT, US Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 1;
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Xiao, L.
AU - Alderisio, K A
AU - Jiang, J
TI - Detection of Cryptosporidium oocysts in water: Effect of the number of samples and analytic replicates on test results
JO - Applied and Environmental Microbiology
PY - 2006/01/01/
VL - 72
IS - 9
SP - 5942
EP - 5947
PB - American Society for Microbiology: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00992240
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 997174. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 997174. Author Affiliation: 2003-2006 Year - Centers for Disease Control and Prevention, Division of Parasitic Diseases, United States Department of Health and Human Services, Mail Stop F-12, 4770 Buford Highway, Atlanta, Georgia 30341-3717, USA 1;
AB - HEALTHLIT Abstract: Due to the small number of Cryptosporidium oocysts in water, the number of samples taken and the analyses performed can affect the results of detection. In this study, 42 water samples were collected from one watershed during 20 storm events over 1 year, including duplicate or quadruplicate samples from 16 storm events. Ten samples from four events had three to eight subsamples. They were processed by EPA method 1623, and Cryptosporidium oocysts present were detected by immunofluorescent microscopy or PCR. Altogether, 24 of 39 samples (47 of 67 samples and subsamples) analyzed by microscopy were positive for Cryptosporidium. In contrast, 36 of 42 samples (62 of 76 samples and subsamples) were positive by PCR, including 10 microscopy-negative samples (13 microscopy-negative samples and subsamples). Six of the 24 microscopy-positive samples were negative by PCR, and all samples had one or less oocyst in a 0.5-ml packed pellet volume calculated. Discordant results were obtained by microscopy and PCR from six and three of the storm events, respectively, with multiple samples. Discordant microscopy or PCR results were also obtained among subsamples. Most of the 14 Cryptosporidium genotypes were found over a brief period. Cryptosporidium-positive samples had a mean of 1.9 genotypes per sample, with 39 of the 62 positive samples/subsamples having more than one genotype. Samples/subsamples with more than one genotype had an overall PCR-positive rate of 73%, compared to 34% for those with one genotype. The PCR amplification rate of samples was affected by the volume of DNA used in PCR
KW - Watersheds / Catchments
KW - Protozoans
KW - Humans
KW - Diseases / Pathogens
KW - Health / Public health
KW - Laboratory experiments
KW - Genetics / Strains / Stock identification
KW - Biochemistry / Molecular biology
KW - Microbiology / Biotechnology
KW - Bacteria
KW - Cryptosporidium spp.
KW - North America
KW - United States
KW - Watersheds / Catchments
KW - Protozoans
KW - Humans
KW - Diseases / Pathogens
KW - Health / Public health
KW - Laboratory experiments
KW - Genetics / Strains / Stock identification
KW - Biochemistry / Molecular biology
KW - Microbiology / Biotechnology
KW - North America
KW - United States
KW - Bacteria
KW - Cryptosporidium spp.
KW - cryptosporidium oocysts
KW - watersheds
KW - pcr [polymerase chain reaction]
KW - immunofluorescent microscopy
KW - detection
KW - water
KW - new york city
KW - kensico reservoir watershed
KW - sample numbers
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Robinson, V.A.
AU - Castranova, V.
AU - Barger, M.W.
AU - Frazer, D.G.
TI - Effect of animal weight on the response of the guinea pig model to inhalation of cotton dust [Language: en]
JO - Proceedings - Beltwide Cotton Production Research Conferences [USA]
PY - 1992/01/01/
VL - 1
SP - 259
EP - 262
AV - Location: US; Number: 9311036
N1 - Database Contributor: AGRIS. Database Contributor ID: US9311036. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9311036. Author Affiliation: Robinson, V.A. : National Institute for Occupational Safety and Health, Morgantown, WV 1;
KW - guinea pigs
KW - weight
KW - application methods
KW - models
KW - occupational hazards
KW - cobaye
KW - poids
KW - methode d'application
KW - modele
KW - risque professionnel
KW - cobaya
KW - peso
KW - metodos de aplicacion
KW - modelos
KW - riesgos ocupacionales
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Dukers-Muijrers, NHTM
AU - Niekamp, A M
AU - Vergoossen, M M H
AU - Hoebe, CJPA
TI - Effectiveness of an opting-out strategy for HIV testing: evaluation of 4 years of standard HIV testing in a STI clinic
JO - Sexually Transmitted Infections
PY - 2009/01/01/
VL - 85
IS - 158
SP - unpaged
PB - British Medical Journal: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN - 13684973
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 1169008. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1169008. Author Affiliation: 2009 Year - Department of Infectious Diseases, South Limburg Public Health Service, PO Box 2022, 6160 HA Geleen, The Netherlands 1;
AB - HEALTHLIT Abstract: Objectives: A high proportion of individuals infected with HIV are unaware of the infection. They miss the opportunity for timely treatment. Our sexually transmitted infection (STI) clinic (South Limburg, The Netherlands) recognised the need to increase test rates and from 2004 routinely includes a HIV test, unless the client refuses, in each consultation. We evaluated the effectiveness of this opting-out approach for HIV testing. Methods: We used anonymised data from our STI clinic from 2003-2007 to assess trends in HIV testing and (reasons for) test refusal using multivariate analyses and interview. Laboratory registry data from the area that is served by the clinic were evaluated as well. Results: In South Limburg the number of HIV tests increased, which was mostly due to increasing STI clinic requests and antenatal screening. Of STI clinic attendees, 84% (1616/1920) were tested in 2003 and this proportion increased to 96% (3699/3836) in 2007. However, 88% (n = 57/65) of men who have sex with men and 44% (191/424) of heterosexuals who refused HIV testing after 2004 were linked to higher STI/HIV risk. Our clinic now uses these findings to develop more effective and tailored HIV/STI counselling in order to further optimise HIV testing practice. Conclusions: Standard testing on HIV in a STI clinic is feasible and effective in increasing awareness of one's HIV status. It should be an essential part of STI screening in STI clinics and should be considered in other healthcare settings for specific risk groups
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - Bacteria / Fungi / Viruses
KW - Europe
KW - Netherlands
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - Bacteria / Fungi / Viruses
KW - Europe
KW - Netherlands
KW - hiv infections
KW - counselling
KW - south limburg
KW - sti [sexually transmitted infections]
KW - interviews
KW - multivariate analyses
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DP - EBSCOhost
DB - awn
ER -
AU - Gubler, Duane J
TI - Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
JO - Trends in Microbiology
PY - 2002/01/01/
VL - 10
IS - 2
SP - 100
EP - 103
SN - 0966842X
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: dgubler@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 11827812. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 11827812. Author Affiliation: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA 1;
AB - MEDLINE Abstract: Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences
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DP - EBSCOhost
DB - awn
ER -
AU - O'Leary, Daniel R
AU - Marfin, Anthony A
AU - Montgomery, Susan P
AU - Kipp, Aaron M
AU - Lehman, Jennifer A
AU - Biggerstaff, Brad J
AU - Elko, Veronica L
AU - Collins, Peggy D
AU - Jones, John E
AU - Campbell, Grant L
TI - The epidemic of West Nile virus in the United States, 2002
JO - Vector Borne and Zoonotic Diseases
PY - 2004/01/01/
VL - 4
IS - 1
SP - 61
EP - 70
SN - 15303667
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: DOLeary@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 15018774. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15018774. Author Affiliation: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Fort Collins, Colorado, USA 1;
AB - MEDLINE Abstract: Since 1999, health officials have documented the spread of West Nile virus across the eastern and southern states and into the central United States. In 2002, a large, multi-state, epidemic of neuroinvasive West Nile illness occurred. Using standardized guidelines, health departments conducted surveillance for West Nile virus illness in humans, and West Nile virus infection and illness in non-human species. Illnesses were reported to the Centers for Disease Control and Prevention (CDC) through the ArboNET system. In 2002, 39 states and the District of Columbia reported 4,156 human West Nile virus illness cases. Of these, 2,942 (71%) were neuroinvasive illnesses (i.e., meningitis, encephalitis, or meningoencephalitis) with onset dates from May 19 through December 14; 1,157 (28%) were uncomplicated West Nile fever cases, and 47 (1%) were clinically unspecified. Over 80% of neuroinvasive illnesses occurred in the central United States. Among meningitis cases, median age was 46 years (range, 3 months to 91 years), and the fatality-to-case ratio was 2%; for encephalitis cases (with or without meningitis), median age was 64 years (range, 1 month to 99 years) and the fatality-to-case ratio was 12%. Neuroinvasive illness incidence and mortality, respectively, were significantly associated with advanced age (p = 0.02; p = 0.01) and being male (p < 0.001; p = 0.002). In 89% of counties reporting neuroinvasive human illnesses, West Nile virus infections were first noted in non-human species, but no human illnesses were reported from 77% of counties in which non-human infections were detected. In 2002, West Nile virus caused the largest recognized epidemic of neuroinvasive arboviral illness in the Western Hemisphere and the largest epidemic of neuroinvasive West Nile virus ever recorded. It is unknown why males appeared to have higher risk of severe illness and death, but possibilities include higher prevalence of co-morbid conditions or behavioral factors leading to increased infection rates. Several observations, including major, multi-state West Nile virus epidemics in 2002 and 2003, suggest that major epidemics may annually reoccur in the United States. Non-human surveillance can warn of early West Nile virus activity and needs continued emphasis, along with control of Culex mosquitoes
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DP - EBSCOhost
DB - awn
ER -
AU - Horton, L
TI - Ethics and trade: exports of unapproved pharmaceuticals and medical devices
JO - Medicine and Law
PY - 1996/01/01/
VL - 15
IS - 4
SP - 649
EP - 662
SN - 07231393
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 9114706. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9114706. Author Affiliation: United States Food and Drug Administration, Rockville, MD 20855, USA 1;
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DP - EBSCOhost
DB - awn
ER -
AU - Danielson, J W
TI - Evaluation of microbial loads of Bacillus subtilis spores on penicylinders
JO - A O A C International. Journal
PY - 1993/01/01/
VL - 76
IS - 2
SP - 355
EP - 360
SN - 10603271
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 12001-21-7; 12597-68-1. Database Contributor: MEDLINE. Database Contributor ID: 8471861. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8471861. Author Affiliation: U.S. Food and Drug Administration, Sterility Analysis Research Center, Minneapolis, MN 55401 1;
AB - MEDLINE Abstract: Three types of penicylinders were compared for their retention of spores of Bacillus subtilis testing for sporicidal activity of disinfectants. Glass, porcelain, and stainless steel penicylinders are inoculated with a water suspension of B. subtilis var. niger (ATCC 9372) spores and dried. One set of each type of penicylinder is submerged 1 h in 0.9% saline. One set of porcelain penicylinders is submerged 15 h in a neutralized chemical germicide, and one set is also inoculated with a culture filtrate of B. subtilis (ATCC 19659), dried according to the AOAC method, and submerged 1 h in 0.9% saline. Microbial loads simulate those held on carriers used to test sporicidal activity of disinfectants. Carriers are immersed in chemical germicide, transferred to a neutralizer, and placed in a culture medium. Average percentages of B. subtilis var. niger spores retained on 10 carriers after 1 h submersion in saline and in water were as follows: glass, 93.6%; porcelain, 99.9%; and stainless steel, 99.5%. Retention of spores after 15 h submersion in a neutralized chemical germicide and in water was 98.9%. Porcelain penicylinders inoculated from a culture filtrate of B. subtilis (ATCC 19659) retained 26% of the spores after being submerged 1 h in saline and placed in water. Glass penicylinders, which retained the lowest and most variable number of spores, were the least suitable for sporicidal activity testing. B. subtilis (ATCC 19659) spores tested on porcelain penicylinders met only the minimum HCl resistance requirements of > or = 2 min. On porcelain penicylinders, the resistance of B. subtilis var. niger spores to 2.5N HCl was relative to the number of spores inoculated
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DP - EBSCOhost
DB - awn
ER -
AU - Horton, L R
TI - Food from developing countries: steps to improve compliance
JO - Food and Drug Law Journal
PY - 1998/01/01/
VL - 53
IS - 1
SP - 139
EP - 171
SN - 1064590X
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 11795330. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 11795330. Author Affiliation: Food and Drug Administration (FDA), USA 1;
AB - MEDLINE Abstract: Developing countries seeking to expand their exports often turn to food exports and seek to market these products in developed countries such as the United States. To be successful, developing countries must overcome an array of obstacles, including the need to comply with the food safety and other requirements of the importing country. This article discusses how compliance with international food norms and national food laws benefits exporting and importing countries, what trends in food trade influence measures to deal with food problems, and what categories of controls are available to deal with good products offered for importation. The article concludes by outlining several suggested steps that can be taken to improve the likelihood of acceptability of food offered for importation. These steps include assessing the needs of the importing country and improving the physical, legal, and technical infrastructure in various ways. Technical assistance from developed countries and international organizations can assist developing countries, but such assistance needs to be carefully designed and coordinated
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DP - EBSCOhost
DB - awn
ER -
AU - Gubler, Duane J
TI - The global emergence/resurgence of arboviral diseases as public health problems
JO - Archives of Medical Research
PY - 2002/01/01/
VL - 33
IS - 4
SP - 330
EP - 342
SN - 01884409
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: dgubler@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 12234522. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 12234522. Author Affiliation: Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA 1;
AB - MEDLINE Abstract: During the past 20 years there has been a dramatic resurgence or emergence of epidemic arboviral diseases affecting both humans and domestic animals. These epidemics have been caused primarily by viruses thought to be under control such as dengue, Japanese encephalitis, yellow fever, and Venezuelan equine encephalitis, or viruses that have expanded their geographic distribution such as West Nile and Rift Valley fever. Several of these viruses are presented as case studies to illustrate the changing epidemiology. The factors responsible for the dramatic resurgence of arboviral diseases in the waning years of the 20th century are discussed, as is the need for rebuilding the public health infrastructure to deal with epidemic vector-borne diseases in the 21st century
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DP - EBSCOhost
DB - awn
ER -
AU - Mullan, R J
TI - Health care workers, tuberculosis, and the human immunodeficiency virus epidemic
JO - Scandinavian Journal of Work, Environment & Health
PY - 1992/01/01/
VL - 18 Su
IS - 2
SP - 97
EP - 99
SN - 03553140
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0. Database Contributor: MEDLINE. Database Contributor ID: 1514102. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1514102. Author Affiliation: National Institute for Occupational Safety and Health Centers for Disease Control, Atlanta, GA 1;
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Henriksen, K
AU - Kaplan, H
TI - Hindsight bias, outcome knowledge and adaptive learning
JO - Quality and Safety in Health Care
PY - 2003/01/01/
VL - 12
IS - 6
SP - ii46
EP - iiii50
PB - British Medical Journal: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN - 14753898
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 1169639. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1169639. Author Affiliation: 2003 Year - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA 1;
AB - HEALTHLIT Abstract: The ubiquitous nature of hindsight bias is a cause for concern for those engaged in investigations and retrospective analysis of medical error. Hindsight does not equal foresight. Investigations that are anchored to outcome knowledge run the risk of not capturing the complexities and uncertainties facing sharp end personnel and why their actions made sense at the time. Important lessons go unlearned if the exercise is simply to back track someone else's decision landmarks. Outcome knowledge can also bias our thinking on the quality of the processes that led to the outcome. This paper examines the influence of outcome knowledge in relation to reconstructive memory and legal testimony, ways for reducing the impact of outcome knowledge, and an adaptive learning framework that places hindsight bias in a broader context of rapid updating of knowledge
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - hindsight
KW - medical error
KW - outcome knowledge
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DP - EBSCOhost
DB - awn
ER -
AU - Bale, A
TI - "Hope in another direction": compensation for work-related illness among women, 1900-1960: Part II
JO - Women & Health
PY - 1989/01/01/
VL - 15
IS - 2
SP - 99
EP - 115
SN - 03630242
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2528860. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2528860. Author Affiliation: Yale Center for Mental Health Services Research, New Haven, CT 06519 1;
AB - MEDLINE Abstract: This article examines compensation for work-related illness among women in the first sixty years of the twentieth century. Its first part (Vol. 15, No. 1) discussed women's experience in the employers' liability system and their workers' compensation claims for poisonings. Part II in this issue examines compensation for infectious diseases, principally tuberculosis; litigation involving lung disease produced by beryllium and asbestos; and women's workers' compensation claims for illnesses involving a mental component
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DP - EBSCOhost
DB - awn
ER -
AU - Bale, A
TI - "Hope in another direction": compensation for work-related illness among women, 1900-1960: Part I
JO - Women & Health
PY - 1989/01/01/
VL - 15
IS - 1
SP - 81
EP - 102
SN - 03630242
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2526414. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2526414. Author Affiliation: Yale Center for Mental Health Services Research, New Haven, CT 06519 1;
AB - MEDLINE Abstract: This two-part article looks at women's attempts to receive compensation for their work-related illnesses in the first sixty years of the twentieth century. Women pressed claims through narrow legal remedies in the tort and workers' compensation systems for a small part of their massive burden of work-related illnesses. Part I examines the network of women advocates around occupational disease compensation; women's experience under the employers' liability and workers' compensation systems; women's most frequently compensated illnesses under workers' compensation, dermatitis and systemic poisoning; and notable litigation episodes involving phosphorus and radium poisoning. Part II of this article, to be published in the next issue, focuses on compensation for tuberculosis, asbestosis, beryllium disease, and illnesses with a mental component
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Williams, T L
AU - Musser, S M
AU - Nordstrom, J L
AU - DePaola, A.
AU - Monday, S R
TI - Identification of a protein biomarker unique to the pandemic O3:K6 clone of Vibrio parahaemolyticus
JO - Journal of Clinical Microbiology
PY - 2004/01/01/
VL - 42
IS - 4
SP - 1657
EP - 1665
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00951137
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 874718. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 874718. Author Affiliation: 2004 Year - Instrumentation and Biophysics Branch, Food and Drug Administration, HFS-717, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 1;
AB - HEALTHLIT Abstract: The present method of characterizing Vibrio parahaemolyticus strains involves serotyping or detection methods based on assessment of the presence or absence of genes thought to be markers of an organism's pathogenicity. It is unclear whether these assays detect all pathogenic V. parahaemolyticus strains since a clear correlation between the presence of a particular gene and the organism's pathogenicity has not yet been observed. We have described a proteomics-based method to distinguish individual V. parahaemolyticus strains on the basis of their protein profiles and identified a specific protein that is characteristic of the pandemic 03:K6 strain and its clonal derivatives. In the pandemic clone of V. parahaemolyticus, a histone-like DNA-binding protein, HU-a, has a C-terminal amino acid sequence different from those of other strains of V. parahaemolyticus. Upon further study, it was discovered that the gene encoding this protein has a 16-kbp insert at the 3' terminus of the open reading frame for this protein. By using the protein sequence of the unique biomarker for the pandemic clone of V. parahaemolyticus, it was possible to rationally design specific PCR-based probes and assays that permit the rapid and precise identification of pandemic strains of V. parahaemolyticus
KW - Genetics / strains / stock identification
KW - Coastal environments
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Technology
KW - Microbiology / biotechnology
KW - Vibrionaceae
KW - Vibrio parahaemolyticus
KW - Genetics / strains / stock identification
KW - Coastal environments
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Technology
KW - Microbiology / biotechnology
KW - Vibrionaceae
KW - Vibrio parahaemolyticus
KW - shellfish
KW - gram negative bacteria
KW - coastal waters
KW - strains
KW - cooking
KW - disease symptoms
KW - characterization
KW - detection methods
KW - gene markers
KW - pathogenicity
KW - protein profiles
KW - amino acid sequencing
KW - biomarkers
KW - pcr analysis
KW - pcr probes
KW - rapid indentification methods
KW - pandemic strains
KW - isolates
KW - geographical orgins
KW - gene insertions [cill]
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DP - EBSCOhost
DB - awn
ER -
AU - Secor, W E
TI - Immunology of human schistosomiasis: off the beaten path
JO - Parasite Immunology
PY - 2005/01/01/
VL - 27
IS - 7-8
SP - 309
EP - 316
SN - 01419838
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: was4@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 16138852. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 16138852. Author Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA 30341-3724, USA 1;
AB - MEDLINE Abstract: Reviews of the immunology of human schistosomiasis generally address the host's protective responses against infection or the factors associated with development of severe pathology. However, there is a growing recognition that the high number of patients expressing moderate morbidity, rather than the few patients with severe morbidity, accounts for the greatest public health impact of schistosomiasis. Therefore, other aspects of the host immune response that have received relatively little attention may actually provide pivotal answers in our understanding and management of the morbidity associated with human schistosomiasis. This review highlights lines of investigation that focus on how immune responses to schistosomiasis may affect schistosomiasis-associated anaemia, alter susceptibility or disease progression during co-infections, and influence effective execution of mass treatment programmes
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DP - EBSCOhost
DB - awn
ER -
AU - Miller, B R
TI - Increased yellow fever virus infection and dissemination rates in Aedes aegypti mosquitoes orally exposed to freshly grown virus
JO - Royal Society of Tropical Medicine and Hygiene. Transactions
PY - 1987/01/01/
VL - 81
IS - 6
SP - 1011
EP - 1012
SN - 00359203
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3503398. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3503398. Author Affiliation: Division of Vector-Borne Viral Diseases, Centers for Disease Control, US Department of Health and Human Services, Fort Collins, Colorado 80521 1;
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DP - EBSCOhost
DB - awn
ER -
AU - Haverkos, H W
TI - Infectious diseases and drug abuse. Prevention and treatment in the drug abuse treatment system
JO - Journal of Substance Abuse Treatment
PY - 1991/01/01/
VL - 8
IS - 4
SP - 269
EP - 275
SN - 07405472
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1787552. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1787552. Author Affiliation: Division of Clinical Research, National Institute on Drug Abuse, United States Public Health Service, Rockville, Maryland 20857 1;
AB - MEDLINE Abstract: Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epidemiology of those infections among drug abusers in the USA, presents rudimentary aspects of medical management of selected infectious diseases, and discusses the need to integrate infectious diseases, drug abuse treatment, and public health approaches if we are to reverse, or at least stabilize, the trends of those diseases
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DP - EBSCOhost
DB - awn
ER -
AU - Secor, W E
TI - Interactions between schistosomiasis and infection with HIV-1
JO - Parasite Immunology
PY - 2006/01/01/
VL - 28
IS - 11
SP - 597
EP - 603
SN - 01419838
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: was4@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 17042931. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 17042931. Author Affiliation: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA 1;
AB - MEDLINE Abstract: In many regions of the world, both schistosomiasis and HIV/AIDS are endemic, resulting in patients harbouring co-infections. Because interaction with host CD4(+) T cells is a characteristic of schistosome as well as HIV-1 infections, bi-directional disease effects may be sufficiently different from sequelae caused by either infectious agent alone to warrant alteration of public health approaches in areas of co-endemnicity. Studies published over the past decade provide useful insights into interactions between schistosomiasis and infection with HIV-1, and overall support the hypothesis that special emphasis on treatment of schistosomiasis in populations with elevated prevalence or risk of HIV-1 infection is justified
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DP - EBSCOhost
DB - awn
ER -
AU - Falk, Henry
TI - International environmental health for the pediatrician: case study of lead poisoning
JO - Pediatrics
PY - 2003/01/01/
VL - 112
IS - 1 Pt 2
SP - 259
EP - 264
SN - 10984275
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; 2P299V784P; E-mail: hxf1@cdc.gov. Database Contributor: MEDLINE. Database Contributor ID: 12837919. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 12837919. Author Affiliation: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia 30341, USA 1;
AB - MEDLINE Abstract: Childhood lead poisoning is a preventable illness. In the past 3 decades, removal of key lead sources and prevention of exposure in the United States have led to dramatic decreases in population blood lead concentrations and also in instances of severe lead poisoning requiring treatment. From an international perspective, childhood lead poisoning seems to be of greatest concern in developing countries. The phasing out of lead from gasoline is a critical first step in decreasing worldwide blood lead concentrations. However, many focal sources that can cause lead poisoning remain, such as lead from flour mills, lead-glazed ceramics, mining and smelting, and battery repair and recycling. A large and diverse country, such as India, may have many sources of lead. The challenge will be for developing countries to implement effective national and regional efforts to address their specific sources of lead
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DP - EBSCOhost
DB - awn
ER -
AU - Whittaker, P
TI - Iron and zinc interactions in humans
JO - American Journal of Clinical Nutrition
PY - 1998/01/01/
VL - 68
IS - 2 Suppl
SP - 442S
EP - 446S
SN - 00029165
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: E1UOL152H7; J41CSQ7QDS; E-mail: pvw@cfsan.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 9701159. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9701159. Author Affiliation: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA 1;
AB - MEDLINE Abstract: Iron deficiency is the most common nutritional deficiency in the world; zinc deficiency is associated with poor growth and development and impaired immune response. Several Third World countries are taking measures to increase the dietary intake of iron and zinc with fortification of foods or dietary supplements. Several studies showed that high iron concentrations can negatively affect zinc absorption in adults when these trace minerals are given in solution. However, when iron and zinc are given in a meal, this effect is not observed. Solomons (J Nutr 1986;116:927-35) postulated that the total amount of ionic species affects the absorption of zinc and that a total dose of >25 mg Fe may produce a measurable effect on zinc absorption. This could occur if iron supplements are taken with a meal, and iron experts recommend that iron supplements be taken between meals. Recent studies using stable isotopes showed that fortifying foods with iron at current fortification amounts has no adverse effect on zinc absorption. There are 5 zinc salts listed as generally recommended as safe (GRAS) by the US Food and Drug Administration for food fortification. From 1970 to 1987, the total amount of zinc salts used in food continually increased, with zinc oxide and zinc sulfate showing the largest increases. Twelve iron sources are listed as GRAS; elemental iron has become the source of choice because it is less expensive to produce and has fewer organoleptic problems. Use of ferrous fumarate is also increasing
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DP - EBSCOhost
DB - awn
ER -
AU - Bier, J W
TI - Isolation of parasites on fruits and vegetables
JO - Southeast Asian Journal of Tropical Medicine and Public Health
PY - 1991/01/01/
VL - 22 Su
SP - 144
EP - 145
SN - 01251562
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 1822873. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1822873. Author Affiliation: Division of Microbiology, Food and Drug Administration, Washington, DC 20204 1;
AB - MEDLINE Abstract: The current FDA method to recover parasites from fruits and vegetables is derived from procedures used to isolate parasitic protozoa from water. A 1kg portion of fruit or vegetable is divided into 200 g subportions. The subportions are sequentially processed in a sonic cleaning bath with 1.5 liters of detergent solution (1% sodium dodecyl sulfate, 0.1% Tween 80) and sonicated for 10 minutes. As each subsample is removed, it is thoroughly drained. After this sonic treatment, the wash water is collected in a polypropylene beaker, transferred to 50 ml polypropylene centrifuge tubes and centrifuged for 15 min at 1500 x g. The sediment is consolidated into one tube along with two rinsings of each tube. The final sediment is fixed in 4% formaldehyde for 10 minutes before examination for parasites. Indirect fluorescent antibody is applied to stain the parasites (Giardia spp. and/or Cryptosporidium spp.) by using commercial kits when available. If a large quantity of extraneous matter is contained in the sediment it may be reduced by layering on Sheather's fluid and centrifuging at 1500 x g for 15 minutes. The supernatant is collected and washed twice in distilled water. This procedure is adequate for protozoa and nonoperculate helminth eggs; operculate helminth eggs may be cleaned by extraction with ethyl acetate. When cabbage and lettuce were seeded at 1 organism/g, the rate of recovery for Cryptosporidium parvum with the FDA method was 1%. When cabbage was seeded at 1 egg/g and 10 eggs/g, the average rate of recovery of decorticated eggs of Ascaris sp. or untreated Trichuris sp. was 10%.(ABSTRACT TRUNCATED AT 250 WORDS)
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Miller, D.
AU - Gillies, P.
TI - Is there life after work? Experiences of HIV and oncology health staff
JO - AIDS Care
PY - 1996/01/01/
VL - 8
IS - 2
SP - 167
EP - 182
PB - Taylor & Francis Group
SN - 09540121
N1 - Database Contributor: AFRICAN DEVELOPMENT DATABASE. Database Contributor ID: 923923. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Place of Publication: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom. Accession Number: 923923. Author Affiliation: USA Environmental Protection Agency 1; University of Florida, Institute of Food and Agricultural Sciences, West Florida Research and Education Center, Department of Wildlife Ecology and Conservation, PO Box 3634, FL 32572-3634, United States 2; Inter-Fluve Inc, 25 North Willson Suite 5, Bozeman, MT 59715, USA 3; FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 70279, USA 4; Environmental Health Programme, School of Public Health, University of Hawaii, 1960 East-West Rd, Honolulu, Hawaii 96822 USA 5; Dunstaffnage Marine Research Laboratory, Oban 6;
AB - AFRICAN DEVELOPMENT Abstract: A cross-sectional interview survey of 103 HIV/AIDS and 100 oncology staff in nine treatment sites in London aimed to identify ways in which work stress affected domestic and social lives of such staff. In all staff, one-third of those without long-term emotional relationships stated they felt their work formed a barrier to their being involved in that way. Most subjects reported spending a considerable amount of time discussing work with partners, and work-related subjects caused conflict for just under half of the total sample. Thirty-nine percent reported their partners complained regularly about their commitment to work, and one-quarter overall reported their relationship had suffered as a result of their work in HIV or oncology. Using tests of association comparing group responses to structured interview and standardized psychometric items, few differences were found overall between staff in HIV/AIDS and staff in oncology. HIV staff were more likely to be motivated to work through peer concern, and friends of HIV staff were more likely to be supportive of their working in such a field. On the other hand, families of oncology staff were more supportive of their work than were families of HIV staff. HIV staff were more likely to have had a family member who had suffered from a chronic or life-threatening disease. HIV staff were less likely to avoid discussing their work socially. Suggestions for addressing the potentially corrosive impact of health care in these fields, based on these samples, are made
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - hiv [human immunodeficiency virus]
KW - aids [acquired immune deficiency syndrome]
KW - oncology staff
KW - health care
KW - health care workers
KW - work-related subjects
KW - hiv/aids care
KW - psychometric items
KW - families
KW - support
KW - hiv patients
KW - hiv care giving
KW - emotional distress
KW - oncology
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=awn&AN=923923&site=ehost-live&scope=site
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Miller, D.
AU - Gillies, P.
TI - Is there life after work? Experiences of HIV and oncology health staff
JO - AIDS Care
PY - 1996/01/01/
VL - 8
IS - 2
SP - 167
EP - 182
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 923923-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 923923-1. Author Affiliation: USA Environmental Protection Agency 1; University of Florida, Institute of Food and Agricultural Sciences, West Florida Research and Education Center, Department of Wildlife Ecology and Conservation, PO Box 3634, FL 32572-3634, United States Inter-Fluve Inc, 25 North Willson Suite 5, Bozeman, MT 59715, USA FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 70279, USA Environmental Health Programme, School of Public Health, University of Hawaii, 1960 East-West Rd, Honolulu, Hawaii 96822 USA Dunstaffnage Marine Research Laboratory, Oban 2;
AB - HEALTHLIT Abstract: A cross-sectional interview survey of 103 HIV/AIDS and 100 oncology staff in nine treatment sites in London aimed to identify ways in which work stress affected domestic and social lives of such staff. In all staff, one-third of those without long-term emotional relationships stated they felt their work formed a barrier to their being involved in that way. Most subjects reported spending a considerable amount of time discussing work with partners, and work-related subjects caused conflict for just under half of the total sample. Thirty-nine percent reported their partners complained regularly about their commitment to work, and one-quarter overall reported their relationship had suffered as a result of their work in HIV or oncology. Using tests of association comparing group responses to structured interview and standardized psychometric items, few differences were found overall between staff in HIV/AIDS and staff in oncology. HIV staff were more likely to be motivated to work through peer concern, and friends of HIV staff were more likely to be supportive of their working in such a field. On the other hand, families of oncology staff were more supportive of their work than were families of HIV staff. HIV staff were more likely to have had a family member who had suffered from a chronic or life-threatening disease. HIV staff were less likely to avoid discussing their work socially. Suggestions for addressing the potentially corrosive impact of health care in these fields, based on these samples, are made
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - Sociology
KW - Bacteria / fungi / viruses
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - Europe
KW - United Kingdom
KW - Great Britain (excludes N. Ire.)
KW - hiv [human immunodeficiency virus]
KW - aids [acquired immune deficiency syndrome]
KW - oncology staff
KW - health care
KW - health care workers
KW - work-related subjects
KW - hiv/aids care
KW - psychometric items
KW - families
KW - support
KW - hiv patients
KW - hiv care giving
KW - emotional distress
KW - oncology
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DP - EBSCOhost
DB - awn
ER -
AU - Rhoades, E R
TI - The major respiratory diseases of American Indians
JO - American Review of Respiratory Disease
PY - 1990/01/01/
VL - 141
IS - 3
SP - 595
EP - 600
SN - 00030805
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 2178526. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 2178526. Author Affiliation: Indian Health Service, U.S. Public Health Service, Rockville, Maryland 20857 1;
AB - MEDLINE Abstract: The most prominent respiratory diseases of American Indian adults are pneumonia, cancer of the lung, chronic obstructive pulmonary disease (COPD), and tuberculosis. Mortality and hospitalization rates of these diseases were compared with those for the rest of the U.S. population and between Indian groups in the various Indian Health Service Areas. Pneumonia and influenza constitute the sixth leading cause of death among Indians and the fifth leading cause of death among the U.S. All Races population. Chronic obstructive pulmonary disease is the fourth leading cause of death among U.S. All Races, but only the tenth leading cause of death among Indians. Pneumonia and tuberculosis are more significant causes of death and disability for Indians than are COPD and cancer of the lung. The explanation for these differences in mortality rates between Indians and the general population are not known. Respiratory system diseases are responsible for 10.6% of Indian hospitalizations. The most frequent is pneumonia, which accounts for approximately 4% of all Indian hospitalizations. Differences in respiratory diseases between Indian groups are sometimes striking, with a sharp increase in mortality and hospitalization in the Areas across the northern border of the lower 48 states. There is also a much higher prevalence of cigarette smoking in those same Areas
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DP - EBSCOhost
DB - awn
ER -
AU - Trask, J W
TI - MALARIA AS A PUBLIC HEALTH AND ECONOMIC PROBLEM IN THE UNITED STATES
JO - American Journal of Public Health
PY - 1916/01/01/
VL - 6
IS - 12
SP - 1290
EP - 1297
SN - 00900036
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 18009591. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 18009591. Author Affiliation: United States Public Health Service 1;
AB - MEDLINE Abstract: Malaria constitutes one of the big national health problems, and because it is a common disease, it receives less consideration than many other diseases less destructive. Doctor Trask here discusses the past and present distribution of this disease and the necessity for an organized fight against it
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DP - EBSCOhost
DB - awn
ER -
AU - Dorothy J Vanderjagt
AU - Jaimie T Sjores
AU - Selina N Okolo
AU - Mark Millson
AU - Ada F Eseogu
AU - Wadinga Wadinga
AU - Robert H Glew
TI - Mineral Content Of The Milk Of Fulani Women And The Sera Of Their Breast-Fed Infants
JO - Highland Medical Research Journal
PY - 2005/05/12/
VL - 1
IS - 2
SP - 6
EP - 11
SN - 15962407
N1 - Database Contributor: AFRICAN JOURNALS ONLINE [AJOL]. Database Contributor ID: hmrj-33795. Database Subset: AFRICAN STUDIES. Language: English. Publication Type: Peer-reviewed Article. Accession Number: hmrj-33795. Author Affiliation: Dorothy J Vanderjagt: Departments of Biochemistry &: Molucular Biology, University of New Mexico, Albuquerque 1; Jaimie T Sjores: Departments of Biochemistry &: Molucular Biology, University of New Mexico, Albuquerque 2; Selina N Okolo: Department of Paediatric, Jos University Teaching Hospital, Jos, Nigeria 3; Mark Millson: National Institute of Occupational Safety and Health Cincinnati, Ohio, USA 4; Ada F Eseogu: Department of Chemical Pathology, Jos University Teaching Hospital, Jos, Nigeria 5; Wadinga Wadinga: Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria 6; Robert H Glew: Departments of Biochemistry &: Molucular Biology, University of New Mexico, Albuquerque 7;
AB - AJOL Abstract: Objectives: TO evaluate the mineral and trace element content of breast milk of the Fulani of Nigeria with respect to levels obtained with sera from Fulani mother baby pairs. Methods: We obtained milk and serum from 34 Fulani mother -infant pairs. The samples were collected through bimanual expression midway through feeding .The age, height, weight, skin -fold thickened, parity, and information regarding the general state of health of each subject were recorded. Following collection, milk and serum specimens were liquated in to 1.5ml cryovials and stored at 20om until which time they were analysed. Results: The levels of calcium, chromium, copper , iron, magnesium ,manganese ,and zinc in the milk were within or exceeded the range of values reported for other populations world wide and were comparable to those of the United States. Copper, zinc ,iron, and calcium decreased in concentration by 550-75% over the first six month postgestation . copper and iron displayed a positive correction between their maternal sera and milk concentrations. No significant positive correction were observed between minerals in milk and the sera of nursing infants, in fact, a negative correction was observed with copper levels of those fluids. Further more , high milk concentration of zinc appeared to antagonize the absorption of copper in the breast -fed infants. Conclusion: These finding indicate that the milk of Fulani women provides sufficient amounts of critical and trace elements to satisfy the needs of their exclusively breast-fed infant during the first six months of life. In addition, the concentration of each of these mineral in infant serum is not related to their respective levels in milk
KW - Human milk
KW - trace element
KW - minerals
KW - Fulani
KW - nutrition
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UR - http://ajol.info/index.php/hmrj/article/view/33795
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Reepmeyer, J C
AU - Ye, W
AU - Ritschel, W A
TI - Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatography
JO - Analytica Chimica Acta
PY - 2008/01/01/
VL - 616
IS - 1
SP - 78
EP - 84
SN - 00032670
AV - Document Delivery: Academic Information Centre; Tel: +27 12 420 2235/6; Fax: +27 12 362 5100
AV - Elsevier Science Ltd: Elsevier BV, PO Box 211, 1000 AE, Amsterdam, The Netherlands.
N1 - Note: NATCHA Location: University of Pretoria (Main Library); Stellenbosch University, Lynnwood Rd, PO Box 12411, Hatfield, Pretoria, 0028; Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. Database Contributor: NATURAL & CULTURAL HERITAGE OF AFRICA NATCHA. Database Contributor ID: NATCHA-1062739. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Accession Number: NATCHA-1062739. Author Affiliation: [2008] - United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101 USA 1;
AB - NATCHA Abstract: Previously, a method was presented for the analysis of mechlorethamine by derivatization of this unstable nitrogen mustard to bis(2-phenylthioethyl)methylamine (PTEMA), a stable compound suitable for analysis by HPLC with UV detection [J.C. Reepmeyer, J. Chromatogr. A, 1085 (2005) 262]. Mechlorethamine HCl served as a reference standard and it was derivatized in situ simultaneously with samples of mechlorethamine HCl in ointment preparations. This paper presents the synthesis of PTEMA on a gram scale, synthesis of its picrate salt, bis(2-phenylthioethyl)methylamine picrate (PTEMAP), and isolation of the picrate as a crystalline solid. PTEMAP may serve as a reference standard replacing the toxic mechlorethamine HCl. Insights into the handling, storage, drying, and hygroscopic properties of mechlorethamine HCl and PTEMAP are discussed. In addition, one step following the derivatization procedure in the original method is recognized as a potential for error, and a procedure relating to the order of addition of reagents is presented to avoid this error. The method has been extended to the analysis of mechlorethamine in aqueous solutions
KW - Chemistry
KW - Water chemistry
KW - Chemistry
KW - Water chemistry
KW - bis[2-phenylthioethyl]methylamine
KW - bis[2-phenylthioethyl]methylamine picrate
KW - derivatization
KW - hplc [high performance liquid chromatography]
KW - mechlorethamine hydrochloride
KW - modifications
KW - nitrogen mustard
KW - nitrogen mustard mechlorethamine
KW - picrate salt
KW - ptema [bis[2-phenylthioethyl]methylamine]
KW - ptemap [bis[2-phenylthioethyl]methylamine picrate]
KW - synthesis
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - DEPAOLA, A
AU - Ulaszek, J
AU - KAYSNER, C A
AU - Tenge, B J
AU - Nordstrom, J L
AU - WELLS, J
AU - Puhr, N
AU - Gendel, S M
TI - Molecular, serological, and virulence characteristics of Vibrio parahaemolyticus isolated from environmental, food, and clinical sources in North America and Asia
JO - Applied and Environmental Microbiology
PY - 2003/01/01/
VL - 69
IS - 7
SP - 3999
EP - 4005
PB - American Society for Microbiology [ASM]: 1752 N St., NW, Washington, DC 20036-2904, USA
SN - 00992240
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 254636. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 254636. Author Affiliation: [1995-2003] - U.S. Food and Drug Administration, Guld Coast Seafood Laboratory Post Office Box 158, Dauphin Island, Alabama 36528, USA 1; Fishery Research Branch, Food and Drug Administration, P.O. Box 158, Dauphin Island, Alabama 36528 2;
AB - HEALTHLIT Abstract: Potential virulence attributes, serotypes, and ribotypes were determined for 178 pathogenic Vibrio parahaemolyticus isolates from clinical, environmental, and food sources on the Pacific, Atlantic, and Gulf Coasts of the United States and from clinical sources in Asia. The food and environmental isolates were generally from oysters, and they were defined as being pathogenic by using DNA probes to detect the presence of the thermostable direct hemolysin (tdh) gene. The clinical isolates from the United States were generally associated with oyster consumption, and most were obtained from outbreaks in Washington, Texas, and New York. Multiplex PCR was used to confirm the species identification and the presence of tdh and to test for the tdh-related hemolysin trh. Most of the environmental, food, and clinical isolates from the United States were positive for tdh, trh, and urease production. Outbreak-associated isolates from Texas, New York, and Asia were predominantly serotype O3:K6 and possessed only tdh. A total of 27 serotypes and 28 ribogroups were identified among the isolates, but the patterns of strain distribution differed between the serotypes and ribogroups. All but one of the O3:K6 isolates from Texas were in a different ribogroup from the O3:K6 isolates from New York or Asia. The O3:K6 serotype was not detected in any of the environmental and food isolates from the United States, and none of the food or environmental isolates belonged to any of the three ribogroups that contained all of the O3:K6 and related clinical isolates. The combination of serotyping and ribotyping showed that the Pacific Coast V. parahaemolyticus population appeared to be distinct from that of either the Atlantic Coast or Gulf Coast. The fact that certain serotypes and ribotypes contained both clinical and environmental isolates while many others contained only environmental isolates implies that certain serotypes or ribotypes are more relevant for human disease
KW - bacteria / fungi / viruses
KW - health / public health
KW - Vibrionaceae
KW - Vibrio parahaemolyticus
KW - North America
KW - Asia
KW - bacteria / fungi / viruses
KW - health / public health
KW - North America
KW - Asia
KW - Vibrionaceae
KW - Vibrio parahaemolyticus
KW - human health
KW - public health
KW - human food
KW - food contamination
KW - microbial contamination
KW - pathogen
KW - seafood
KW - oyster
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Zhou, L
AU - Singh, A
AU - Jiang, J
AU - Xiao, L.
TI - Molecular surveillance of Cryptosporidium spp. in raw wastewater in Mulwaukee: implications for understanding outbreak occurrence and transmisison dynamics
JO - Journal of Clinical Microbiology
PY - 2003/01/01/
VL - 41
IS - 11
SP - 5254
EP - 5257
PB - AMERICAN SOCIETY FOR MICROBIOLOGY: 1752 N St, NW, Washington, DC 20036-2904, USA
SN - 00951137
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 862119. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 862119. Author Affiliation: 2003 Year - ection, Ottawa, Ontario, Canada 1; United States Department of Health and Human Services, Public Health Services, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Parasitic Diseases, Building 22, Mail Stop F-12, 4770 Buford Highway, Atlanta, GA 30341, USA or lax@cdc.gov or lax0@cdc.gov 2; Department of Medical Virology, Institute of Pathology, University of Pretoria, P O BOx 2034, Pretoria 0002, South Africa 3;
AB - HEALTHLIT Abstract: Six Cryptosporidium spp. were found in 50 of 179 Milwaukee wastewater samples collected weekly over a year. Of the eight subtypes of Cryptosporidium hominis and Cryptosporidium parvum present, allele Ib was found in 14 of 16 samples, and its sequence was identical to that of the subtype in human samples from the 1993 Milwaukee outbreak of cryptosporidiosis
KW - Biochemistry / molecular biology
KW - Parasites
KW - Genetics / strains / stock identification
KW - Microbiology / biotechnology
KW - Waste Water
KW - Diseases / pathogens
KW - Health / public health
KW - Gymnamoebia
KW - Cryptosporidium hominis
KW - Gymnamoebia
KW - Cryptosporidium parvum
KW - North America
KW - United States
KW - Wisconsin
KW - Biochemistry / molecular biology
KW - Parasites
KW - Genetics / strains / stock identification
KW - Microbiology / biotechnology
KW - Waste Water
KW - Diseases / pathogens
KW - Health / public health
KW - North America
KW - United States
KW - Wisconsin
KW - Gymnamoebia
KW - Cryptosporidium hominis
KW - Gymnamoebia
KW - Cryptosporidium parvum
KW - milwaukee
KW - disease outbreaks
KW - surveillance
KW - disease transmission
KW - subtypes
KW - alleles
KW - strains
KW - human genotype
KW - bovine genotype
KW - cryptosporidiosis
KW - pcr [polymerase chain reaction]
KW - pcr assays
KW - dna extractions
KW - gene sequence analysis
KW - water borne diseases
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DP - EBSCOhost
DB - awn
ER -
AU - Brennan, M J
TI - Moving new vaccines for tuberculosis through the regulatory process
JO - Clinical Infectious Diseases
PY - 2000/01/01/
VL - 30 Su
IS - 3
SN - 10584838
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; E-mail: Brennan@cber.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 10875792. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10875792. Author Affiliation: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA 1;
AB - MEDLINE Abstract: The development of novel vaccines for the prevention of tuberculosis is an area of intense interest for scientific researchers, public health agencies, and pharmaceutical manufacturers. Development of effective new vaccines directed against tuberculosis for use in target populations will require close cooperation among several different international organizations, including regulatory agencies responsible for evaluating the safety and effectiveness of new biologics for human use
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DP - EBSCOhost
DB - awn
ER -
AU - Collins, F M
TI - Mycobacterial pathogenesis: a historical perspective
JO - Frontiers in Bioscience
PY - 1998/01/01/
VL - 3
EP - 448
SN - 10939946
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: collinsf@a1.cber.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 9669994. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9669994. Author Affiliation: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA 1;
AB - MEDLINE Abstract: Tuberculosis is an age-old human affliction which continues to flourish worldwide despite the development of effective drugs for its treatment and a vaccine (BCG) for its prevention. At least 8 million people die from this disease each year, a figure which is likely to increase as the AIDS epidemic continues its relentless spread into Africa and Southeast Asia. Consumption was shown to be caused by Mycobacterium tuberculosis more than a century ago, yet we still know very little about the mechanisms used by this organism to elude the normally effective cellular host defenses as it establishes a progressive infection within the lung. The majority of individuals exposed to tuberculous infection are able to limit the primary infection to the lungs and its lymph nodes, resulting in a latent form of the disease which can provide the host with a lifelong immunity to reinfection. While a great deal is known about the cellular mediators of this immune response (together with the cytokines which modulate them) we lack a clear understanding of the role that they play during the establishment of the dormant form of the disease. Live BCG vaccine has been widely used in many Third World countries as a major component of their tuberculosis control programs. However, several carefully controlled human trials have shown little protection achieved in vaccinated individuals. Development of improved vaccines, both for the prevention and therapy of this disease is an urgent research priority and a number of potential immunogens are under active investigation. However, our limited understanding of the pathogenesis of this chronic disease, together with a lack of data on the role played by different bacterial components in the modulation of the immune response, continues to severely limit our ability to develop a rational approach to this project. To achieve this goal, it will be necessary to establish innovative approaches to the presentation of protective antigens by taking advantage of recent advances in the molecular biology of this complex and enigmatic group of organisms
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Lawless, L.S.
TI - A new record of Cryptolestes ugandae Steel and Howe in an imported food product from Ghana [Coleoptera: Cucujidae] [Language: en]
JO - Coleopterists Bulletin
PY - 1995/12/01/
VL - 49
IS - 4
SP - 312
EP - 312
SN - 0010065X
AV - Location: *US (DNAL 421 C674); Number: 9633680
N1 - Database Contributor: AGRIS. Database Contributor ID: US9633680. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9633680. Author Affiliation: Lawless, L.S. : U.S. Food and Drug Administration, Baltimore, MD 1;
KW - ghana
KW - maryland
KW - cryptolestes
KW - stored products pests
KW - imports
KW - melons
KW - seeds
KW - ravageur des denrees entreposees
KW - importation
KW - melon
KW - graine
KW - plagas de productos almacenados
KW - importaciones
KW - semilla
KW - new geographic records
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Baer, G.M.
AU - Brooks, R.C.
AU - Foggin, C.M.
TI - Oral vaccination of dogs fed canine adenovirus in baits [Language: en]
JO - American Journal of Veterinary Research
PY - 1989/06/01/
VL - 50
IS - 6
SP - 836
EP - 837
SN - 00029645
AV - Location: US; Number: 9015928
N1 - Database Contributor: AGRIS. Database Contributor ID: US9015928. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9015928. Author Affiliation: Baer, G.M. : US Department of Health and Human Services, Lawrenceville, GA 1;
AB - Six groups of 5 dogs each were fed dilutions of canine adenovirus-2, either as raw liquid or after insertion into cornmeal baits. By the fourth week after vaccination, 29 of the 30 dogs developed high titers of serum-neutralizing antibodies to the virus
KW - chien
KW - zimbabwe
KW - immunisation
KW - attractif
KW - mastadenovirus canin
KW - vaccin
KW - animal sauvage
KW - rage
KW - zoonose
KW - controle de maladies
KW - perro
KW - inmunizacion
KW - atrayentes
KW - adenovirus canino
KW - vacuna
KW - animal salvaje
KW - rabia
KW - zoonosis
KW - control de enfermedades
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Battles, J B
AU - Lilford, R J
TI - Organizing patient safety research to identify risks and hazards
JO - Quality and Safety in Health Care
PY - 2003/01/01/
VL - 12
IS - 6
SP - ii2
EP - iiii7
PB - British Medical Journal: B M A House, Tavistock Sq, London WC1H 9JR United Kingdom
SN - 14753898
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 1169632. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 1169632. Author Affiliation: 2003 Year - Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, 540 Gaither Road, Rockville, MD 20850, USA 1;
AB - HEALTHLIT Abstract: Patient safety has become an international priority with major research programmes being carried out in the USA, UK, and elsewhere. The challenge is how to organize research efforts that will produce the greatest yield in making health care safer for patients. Patient safety research initiatives can be considered in three different stages: (1) identification of the risks and hazards; (2) design, implementation, and evaluation of patient safety practices; and (3) maintaining vigilance to ensure that a safe environment continues and patient safety cultures remain in place. Clearly, different research methods and approaches are needed at each of the different stages of the continuum. A number of research approaches can be used at stage 1 to identify risks and hazards including the use of medical records and administrative record review, event reporting, direct observation, process mapping, focus groups, probabilistic risk assessment, and safety culture assessment. No single method can be universally applied to identify risks and hazards in patient safety. Rather, multiple approaches using combinations of these methods should be used to increase identification of risks and hazards of health care associated injury or harm to patients
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - North America
KW - United States
KW - Europe
KW - United Kingdom
KW - England
KW - Health / Public health
KW - Medical Science
KW - Humans
KW - North America
KW - United States
KW - Europe
KW - United Kingdom
KW - England
KW - safety culture
KW - injury
KW - medical records
KW - hazards
KW - risks
KW - patient safety
KW - international priority
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DP - EBSCOhost
DB - awn
ER -
AU - Markoff, L
TI - Points to consider in the development of a surrogate for efficacy of novel Japanese encephalitis virus vaccines
JO - Vaccine
PY - 2000/01/01/
VL - 18 Su
IS - 2
SP - 26
EP - 32
SN - 0264410X
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0. Database Contributor: MEDLINE. Database Contributor ID: 10821970. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 10821970. Author Affiliation: Laboratory of Vector-borne Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1448, USA 1;
AB - MEDLINE Abstract: Although an effective killed virus vaccine to prevent illness due to Japanese encephalitis virus (JEV) infection exists, many authorities recognize that a safe, effective live JEV vaccine is desirable in order to reduce the cost and the number of doses of vaccine required per immunization. A large-scale clinical efficacy trail for such a vaccine would be both unethical and impractical. Therefore, a surrogate for the efficacy of JE vaccines should be established. Detection of virus-neutralizing antibodies in sera of vaccinees could constitute such a surrogate for efficacy. Field studies of vaccinees in endemic areas and studies done in mice already exist to support this concept. Also, titers of virus-neutralizing antibodies are already accepted as a surrogate for the efficacy of yellow fever virus vaccines and for the efficacy of other viral vaccines as well. In developing a correlation between N antibody titers and protection from JEV infection, standard procedures must be validated and adopted for both measuring N antibodies and for testing in animals. A novel live virus vaccine could be tested in the mouse and/or the monkey model of JEV infection to establish a correlation between virus-neutralizing antibodies elicited by the vaccines and protection from encephalitis. In addition, sera of subjects receiving the novel live JEV vaccine in early clinical trials could be passively transferred to mice or monkeys in order to establish the protective immunogenicity of the vaccine in humans. A monkey model for JEV infection was recently established by scientists at WRAIR in the US. From this group, pools of JEV of known infectivity for Rhesus macaques may be obtained for testing of immunity elicited by live JE vaccine virus
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DP - EBSCOhost
DB - awn
ER -
AU - Dora Akunyili
AU - Paul Okonkwo
TI - Poor manufacturing practice [PMP] and near fatalities in Emergency Care: report of three cases
JO - Journal of College of Medicine
PY - 2002/02/01/
VL - 7
IS - 2
SP - 128
EP - 128
N1 - Database Contributor: AFRICAN JOURNALS ONLINE [AJOL]. Database Contributor ID: jcm-10449. Database Subset: AFRICAN STUDIES. Language: English. Publication Type: Peer-reviewed Article. Accession Number: jcm-10449. Author Affiliation: Dora Akunyili: National Agency for Food and Drug Administration control, Abuja 1;
AB - AJOL Abstract: Copyright for articles published in this journal is retained by the journal
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UR - http://ajol.info/index.php/jcm/article/view/10449
DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Seo KW
AU - Park M
AU - Song YJ
AU - Kim S
AU - Yoon KR
TI - The Protective Effects of Propolis on Hepatic Injury and its Mechanism
JO - Phytotherapy Research
PY - 2003/01/01/
VL - 17
IS - 3
SP - 250
EP - 253
SN - 0951418X
N1 - Note: E-mail: kwseo@kfda.go.kr. Database Contributor: AFRICAN LABORATORY FOR NATURAL PRODUCTS DATABASE [ALNAP]. Database Contributor ID: ALNAP-022497. Database Subset: AFRICAN HEALTHLINE. Document Type: Article. Publication Type: Journal Article. Accession Number: ALNAP-022497. Author Affiliation: Dr K.W. Seo, Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyunggu, Seoul 122-020, Korea 1;
AB - ALNAP Abstract: Propolis (PP) is a sticky substance that is collected from plants by honeybees. The purpose of this study was to investigate the protective effects of PP on hepatotoxicity induced by acetaminophen (AA, paracetamol) and the mechanism of its hepatoprotective effect. In rat hepatocyte culture, pretreatment with PP (1, 10, 100, 200 and 400 mg/mL, 24 h) significantly decreased the cytotoxicity of AA (0.5 mM) in a dose-dependent manner. In mice, pretreatment with PP (10 and 25 mg/kg, p.o., 7 days) also decreased the mortality and the incidence and severity of hepatic necrosis induced by AA (400 mg/kg, i.p.). After treatment with PP for 7 days, the hepatic enzyme activities of cytochrome P450 monooxygenases (P450s), UDP-glucuronyltransferase, phenolsulphotransferase (PST), glutathione S-transferase (GST) were measured in both rats and mice. In rats, PP (50 and 100 mg/kg, p.o.) decreased the activity of P4502E1, but significantly increased the activities of GST and PST. On the other hand, in mice treated with PP (10 and 25 mg/kg, p.o.), the activities of P4501A2, 2B1, 3A4 and 2E1 were dramatically inhibited, and the activity of PST was significantly enhanced. These results suggest that PP has a protective effect on hepatic injury, and that its effect may be explained by inhibition of phase I enzymes and induction of phase II enzymes
KW - Korea
KW - Senait
KW - Korea
KW - Senait
KW - AA
KW - acetaminophen
KW - activity
KW - culture
KW - Cytochrome P450
KW - cytochrome P450 monooxygenases
KW - cytotoxicity
KW - Department
KW - dose-dependent
KW - drug
KW - effect
KW - enzyme
KW - enzymes
KW - food
KW - glutathione
KW - Glutathione S-transferase
KW - GST.
KW - hepatic enzyme
KW - Hepatoprotective
KW - Hepatoprotective effect
KW - Hepatotoxicity
KW - honeybee
KW - inhibition
KW - Korea
KW - mechanism
KW - mice
KW - mortality
KW - necrosis
KW - P450
KW - P450s
KW - Paracetamol
KW - plant
KW - plants
KW - propolis
KW - Protective Effect
KW - PST
KW - Rat
KW - Rats
KW - research
KW - S-transferase
KW - Substance
KW - Toxicological
KW - toxicology
KW - treatment
KW - UDP-GT
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DP - EBSCOhost
DB - awn
ER -
AU - McNamara, Peggy
TI - Provider-specific report cards: a tool for health sector accountability in developing countries
JO - Health Policy and Planning
PY - 2006/01/01/
VL - 21
IS - 2
SP - 101
EP - 109
SN - 02681080
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: pmcnamar@ahrq.gov. Database Contributor: MEDLINE. Database Contributor ID: 16431878. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 16431878. Author Affiliation: Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA 1;
AB - MEDLINE Abstract: In most health care systems in most countries, providers are not adequately held accountable - by governments, purchasers, provider professional associations or civil society - for the quality of care. One approach to improve provider accountability that is being debated and implemented in a subset of developed countries and a smaller group of developing countries is provider-specific comparative performance reporting. This review discusses universal design options for report cards, summarizes the evidence base, presents developing country examples, reviews challenges and outlines implementation steps. The ultimate aim is to provoke thoughtful debate about if and how comparative performance reporting fits within a developing country's broader framework of strategies to promote quality of care
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DP - EBSCOhost
DB - awn
ER -
AU - Baker, Duiona R
TI - A public health approach to the needs of children affected by terrorism
JO - American Medical Women's Association. Journal
PY - 2002/01/01/
VL - 57
IS - 2
SP - 117
SN - 00988421
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 11991421. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 11991421. Author Affiliation: Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA 1;
AB - MEDLINE Abstract: The devastating terrorist incidents of Pan Am Flight 103, the Oklahoma City bombing, the bombings of the embassies in Kenya and Tanzania, and the World Trade Center attack of September 11, 2001, have forever changed America. These terrorist acts have deeply shaken the sense of safety, security, and well-being of our surviving children and families. These terrorist acts may also have increased the public health risks of substance abuse and mental illness for our children. The Substance Abuse and Mental Health Services Administration is responsible for strengthening prevention and treatment of substance abuse and mental illness in children and families. America's children may exhibit a wide range of emotional, physical, and psychological reactions following natural and man-made disasters. Large-scale disasters witnessed by children all underscore the need for a broad mental health and substance abuse public health approach. This approach is critical for our children's well-being
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Castranova, V.
AU - Robinson, V.A.
AU - Goldsmith, W.T.
AU - Phillips, N.A.
AU - Afsari, A.
AU - Frazer, D.G.
TI - Pulmonary inflammation of guinea pigs in response to inhalation of cotton dust: effect of extended exposure day [Language: en]
JO - Beltwide Cotton Conferences [USA]
PY - 1998/01/01/
VL - 1
SP - 220
EP - 224
SN - 10592644
AV - Location: *US (DNAL SB249.N6); Number: 1999007321
N1 - Database Contributor: AGRIS. Database Contributor ID: US1999007321. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US1999007321. Author Affiliation: Castranova, V. : National Institute for Occupational Safety and Health, Morgantown, WV 1;
KW - cotton
KW - dust
KW - textile industry
KW - respiratory diseases
KW - bioassays
KW - guinea pigs
KW - dosage effects
KW - coton
KW - poussiere
KW - industrie textile
KW - maladie respiratoire
KW - test biologique
KW - cobaye
KW - effet dose
KW - algodon
KW - polvo [contaminantes]
KW - industria textil
KW - enfermedades respiratorias
KW - ensayo biologico
KW - cobaya
KW - efectos de dosificacion
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Frazer, D.G.
AU - Robinson, V.A.
AU - Weber, K.C.
AU - Jones, W.
AU - Siegel, P.D.
AU - Barger, M.W.
AU - Masters, B.
AU - Chandler, C.A.
AU - Vincent, D.
AU - Castranova, V.
TI - Pulmonary response of the guinea pig animal model to n-formyl-methionyl-leucyl-phenylalanine [FMLP] liquid aerosol [Language: en]
JO - Proceedings - Beltwide Cotton Production Research Conferences [USA]
PY - 1992/01/01/
VL - 1
SP - 266
EP - 270
AV - Location: US; Number: 9319619
N1 - Database Contributor: AGRIS. Database Contributor ID: US9319619. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9319619. Author Affiliation: Frazer, D.G. : National Institute for Occupational Safety and Health, Morgantown, WV 1;
KW - guinea pigs
KW - cotton
KW - dust
KW - cobaye
KW - coton
KW - poussiere
KW - cobaya
KW - algodon
KW - polvo [contaminantes]
KW - exposure
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DP - EBSCOhost
DB - awn
ER -
AU - McNamara, Peggy
TI - Quality-based payment: six case examples
JO - International Journal for Quality in Health Care
PY - 2005/01/01/
VL - 17
IS - 4
SP - 357
EP - 362
SN - 13534505
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: pmcnamar@ahrq.gov. Database Contributor: MEDLINE. Database Contributor ID: 15879011. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15879011. Author Affiliation: Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD 20850, USA 1;
AB - MEDLINE Abstract: INTRODUCTION: The logic of paying more for high-quality care and less for low-quality resonates. Increasingly health system leaders worldwide acknowledge that payment reforms are needed to do just that, prompted no doubt by the growing body of evidence indicating that quality is not what it should be. PURPOSE: This review was undertaken to explore contexts in which quality-based payment appears feasible. The ultimate intent is to provoke thoughtful debate about whether and how quality-based payment might fit within a particular developing country's framework of policies to ensure and promote quality of care. METHODS: With guidance from key informants with first-hand knowledge of international quality-based payment schemes, a purposive sample of six quality-based payment schemes was assembled. Schemes were examined to identify environmental contexts and design features. RESULTS: Examples illustrate a variety of approaches and a breadth of contexts in which quality-based payment has been implemented. Contrary to what might be expected, implementation does not appear to be constrained to private-sector purchasers, private-sector providers, hospital settings, nor to any particular type of underlying payment system. Further, quality-based payment pioneers are using a variety of incentive structures, and are tapping a rich mix of structural, process, and outcome standards to benchmark quality. CONCLUSION: Despite significant operational challenges, quality-based payment has been implemented in developing as well as developed countries, albeit not frequently in either instance. What we do not know--what the literature is nearly silent on--relates to the sustainability and ultimate impact of alternative incentive schemes
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DP - EBSCOhost
DB - awn
ER -
AU - Frasch, Carl E
TI - Recent developments in Neisseria meningitidis group A conjugate vaccines
JO - Expert Opinion on Biological Therapy
PY - 2005/01/01/
VL - 5
IS - 2
SP - 273
EP - 280
SN - 14712598
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; E-mail: Frasch@cber.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 15757388. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15757388. Author Affiliation: Center for Biologics Evaluation and Research, Laboratory of Bacterial Polysaccharides, Division of Bacterial Parasitic and Allergenic Products, FDA, 1401 Rockville Pike, Rockville, MD 20852, USA 1;
AB - MEDLINE Abstract: Meningococcal disease, both endemic and epidemic, remains a major cause of meningitis in many countries. Protective immunity is mediated primarily by bacteriocidal antibodies against the capsular polysaccharides for serogroups other than B, and against non-capsular surface components for group B. This article focuses on the development of conjugate vaccines for serogroup A, with special emphasis on the needs of Africa. The first licensed (1999) meningococcal conjugate was against group C in the UK and was > 90% effective in infants, children and young adults. The problem now is to develop a highly immunogenic group A meningococcal conjugate vaccine for use in developing countries as an alternative to the presently licensed group AC polysaccharide vaccine. Immunogenicity studies on the group A polysaccharide show the polysaccharide itself to be uniquely immunogenic in young children compared with other polysaccharides, making comparative studies with a highly immunogenic conjugate of considerable importance
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Falk, L A
AU - Goldenthal, K L
AU - Esparza, J
AU - Aguado, M T
AU - Osmanov, S
AU - Ballou, W R
TI - Recombinant Bacillus Calmette-Guerin as a potential vector for preventive HIV Type 1 vaccines
JO - AIDS Research and Human Retroviruses
PY - 2000/01/01/
VL - 16
IS - 2
SP - 91
EP - 98
PB - Mary Ann Liebert, Inc. Publishers: 140 Huguenot Street, 3rd Floor, New Rochelle, New York, 10801-5215, USA
SN - 08892229
N1 - Note: HEALTHLIT Location: Stellenbosch University, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 968365. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 968365. Author Affiliation: 2000 Year - US Food and Drug Administration, Center for Biologies Evaluation and Research, Office of Vaccines Research and Review, Rockville, Maryland 20852, USA 1;
AB - HEALTHLIT Abstract: In August 1997, the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) convened an expert working group to discuss current strategies for the development of HIV type 1 vaccines. Based on the recent findings of investigators from Japan's National Institute of Infectious Diseases (NIID) in Tokyo using recombinant bacillus Calmette-Guerin (rBCG) as a potential vectored vaccine for HIV, a recommendation was made that further work in this area is a priority. As a result, the working group reconvened in September 1998 to discuss the progress to date with this vaccine approach, as well as areas of related research to assess the feasibility of a BCG-vectored HIV vaccine. This report summarizes the discussions addressing the available scientific data on the potential use of rBCG as a vector for preventive HIV vaccines, the work necessary to move such candidate vaccines into Phase 1 clinical trials, and recommendations targeted at facilitating the long-term development of rBCG-vectored HIV vaccines
KW - Biochemistry / Molecular biology
KW - Microbiology / Biotechnology
KW - Medical Science
KW - Health / Public health
KW - Bacteria / Fungi / Viruses
KW - North America
KW - United States
KW - Maryland
KW - Biochemistry / Molecular biology
KW - Microbiology / Biotechnology
KW - Medical Science
KW - Health / Public health
KW - Bacteria / Fungi / Viruses
KW - North America
KW - United States
KW - Maryland
KW - hiv [human immunodeficiency virus]
KW - hiv vaccine development
KW - hiv vaccine trials
KW - infectious diseases
KW - who [world health organisation]
KW - unaids [united nations programme on hiv/aids]
KW - hiv type 1 vaccines
KW - hiv-1 [human immunodeficiency virus type 1]
KW - vectored vaccine
KW - rbcg [recombinant bacillus calmette guerin]
KW - recombinant adenovirus
KW - recombinant bacillus
KW - hiv vectored vaccine
KW - bacillus calmette guerin vaccination
KW - bacillus calmette guerin
KW - preventive hiv vaccines
KW - clinical trials
KW - vaccination trials
KW - viral vectors
KW - vaccine vectorsc cell stimulation
KW - algorithm simulationn
KW - emerging diseases
KW - disease dynamics
KW - hiv type 1 origins organisations]
KW - community resources
KW - emergency responses
KW - hiv prevention
KW - hiv treatment
KW - hiv care
KW - hiv investments
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Conviser, R.
AU - Pounds, MB.
TI - The role of ancillary services in client-centred systems of care
JO - AIDS Care
PY - 2002/01/01/
VL - 14
IS - Supplement 1
SP - 119
EP - 131
PB - Taylor & Francis Group: 4 Park Sq, Milton Park, Abingdon OX14 4RN United Kingdom
SN - 09540121
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 968173-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 968173-1. Author Affiliation: 2002 Year - Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, USA 1;
AB - HEALTHLIT Abstract: The studies in this issue reflect the operation of the Ryan White CARE Act's holistic model of health and support services for people living with HIV in the USA. Ancillary services available through the CARE Act are responsive to predisposing factors, enabling factors, and system characteristics that pose barriers to clients' receipt of primary medical care. That nearly all of the studies use cross-sectional rather than longitudinal data makes it difficult to draw causal inferences. Taken as a whole, however, the studies suggest that receipt of ancillary services such as case management, mental health and substance abuse treatment, transportation, and housing assistance is associated with primary care entry and retention among CARE Act clients. The studies and the literature out of which they arise suggest that there is a need to refine further our understanding of care systems so that we can refine the care systems themselves. Among the concepts proposed for the study of care systems are comprehensiveness, capacity, coordination, integration, cultural competence, and client-centredness
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - North America
KW - United States
KW - Maryland
KW - Bacteria / fungi / viruses
KW - Diseases / pathogens
KW - Health / public health
KW - Medical Science
KW - Behaviour / psychology
KW - North America
KW - United States
KW - Maryland
KW - primary care
KW - ancillary care services
KW - ryan white care act
KW - case management
KW - mental health
KW - substance abuse
KW - transportation
KW - housing
KW - care systems
KW - hiv [human immunodeficiency virus]
KW - hiv care
KW - hiv knowledge
KW - care management
KW - cultural competence
KW - holistic health care
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DP - EBSCOhost
DB - awn
ER -
AU - Miliotis, M
TI - Role of microbial risk assessment in food safety
JO - S A M J South African Medical Journal
PY - 2007/01/01/
VL - 97
IS - 11 Pt 3
SP - 1211
EP - 1214
SN - 02569574
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: marianna.miliotis@fda.hhs.gov. Database Contributor: MEDLINE. Database Contributor ID: 18250940. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 18250940. Author Affiliation: United States Food and Drug Administration, USA 1;
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DP - EBSCOhost
DB - awn
ER -
AU - Lin, Kenneth W
TI - Screening for sickle cell disease in newborns
JO - American Family Physician
PY - 2009/01/01/
VL - 79
IS - 6
SP - 507
EP - 508
SN - 0002838X
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 19323364. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 19323364. Author Affiliation: U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, USA 1;
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Deeds, J R
AU - Place, A R
TI - Sterol-specific membrane interactions with the toxins from Karlodinium micrum [Dinophyceae] - a strategy for self-protection
JO - African Journal of Marine Science
PY - 2006/01/01/
VL - 28
IS - 2
SP - 421
EP - 425
PB - NISC
SN - 1814232X
N1 - Database Contributor: AFRICAN PUBLICATIONS. Database Contributor ID: 1618170. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Article. Place of Publication: 19 Worcester Street, Grahamstown, South Africa. Conference: Proceedings of the 11th International Conference on Harmful Algae. Conference Date: 15-19 November 2004. Conference Location: Harmful Algae, Cape Town, South Africa. Accession Number: 1618170. Author Affiliation: [2006] - Washington Seafood Laboratory, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA 1; Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 2120, USA 2;
AB - AFRICAN PUBLICATIONS Abstract: The lipophilic toxins from Karlodinium micrum, KmTX, have negative effects on several co-occurring phytoplankton species, yet appear to have no effect on K. micrum itself. One of these compounds, KmTX2, has differing toxicity towards eukaryotic membranes with differing sterol compositions (vertebrate greater than fungal greater than dinoflagellate). It is shown that KmTX2 causes lysis in a co-occurring potential grazer Oxyrrhis marina while having no effect on K. micrum itself. K. micrum has a unique membrane sterol profile dominated by (24S)-4alpha-methyl-5alpha-ergosta-8(14),22-dien-3beta-ol (gymnodinosterol), whereas O. marina was shown to possess 5,22-cholestadien-24beta-methyl-3beta-ol (brassicasterol) and 5cholesten-3beta-ol (cholesterol) as its major membrane sterols. In accord with toxicity data from whole cells containing these sterols, free sterols were found to inhibit haemolysis in the order cholesterol greater than ergosterol greater than gymnodinosterol. It appears that certain sterols can form stable complexes with the toxin molecule, thereby sequestering it away from erythrocyte membranes. It is concluded that K. micrum protects itself from the membrane-disrupting properties of its own toxins by possessing a membrane sterol that does not interact with these compounds
KW - Toxicology / toxicity
KW - Biochemistry / molecular biology
KW - Algae
KW - Dinophyceae
KW - Karlodinium micrum
KW - Toxicology / toxicity
KW - Biochemistry / molecular biology
KW - Algae
KW - Dinophyceae
KW - Karlodinium micrum
KW - membrane specificities
KW - gymnodinosterol
KW - karlotoxin
KW - self protection strategies
KW - lipophilic toxins
KW - sterol compositions
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Kim, H.Y
AU - Yoon, H.J
AU - Choi, J.D
AU - Choi, W.J
AU - Park, S.Y
AU - Lee, K.J
AU - Kim, J.H.
TI - A Study for Analytical Method of Sudan Colorants in Foods [Language: en]
T2 - 식품 중 수단색소의 분석법에 관한 연구 [Language: Ko]
JO - Journal of The Korean Society of Food Science and Nutrition
PY - 2004/03/01/
VL - 33
IS - 3
SP - 549
EP - 552
SN - 12263311
AV - Location: KR; Number: 2005009290
N1 - Database Contributor: AGRIS. Database Contributor ID: KR2005009290. Database Subset: AFRICAN STUDIES. Language: Korean. Document Type: Article. Publication Type: Journal Article. Accession Number: KR2005009290. Author Affiliation: Korea Food and Drug Administration, Seoul, Republic of Korea E-mail:pmheekim@kfda.go.kr 1;
AB - A simple, efficient and accurate method was developed for the simultaneous determination of non-permitted oil soluble colorants (sudan Ⅰ, Ⅱ, Ⅲ and Ⅳ) in foods. The identification has been carried out for sudan colorants by TLC as well as HPLC with photodiode array (PDA) detection. Separation of sudan colorants was achieved within 20 min by a gradient elution with water and acetonitrile as eluents. Sudan colorants showed good linear relationships in the range of 0.1~100 ㎍/mL. The correlation coefficients of the calibration curve for sudan colorants exceeded 0.999. The detection limits (signal-to-noise ratio 3:1) for sudan Ⅰ, Ⅱ, Ⅲ and Ⅳ were 0.01, 0.01, 0.02 and 0.02 ㎍/mL, respectively
KW - sudan colorant
KW - hplc-pda
KW - red poppet powder
KW - 식품수단색소분석법
KW - sudan
KW - powders
KW - soudan
KW - poudre
KW - polvos [formulaciones]
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Lee, J.K.
AU - Ryu, S.R.
AU - Kim, D.B.
AU - Lee, S.H.
AU - Kim, P.Y.
AU - Lee, Y.S.
TI - Subcutaneous implantation test of self-curing resins in guinea pigs [Language: en]
JO - The Korean Journal of Laboratory Animal Science [Korea Republic]
PY - 1997/12/01/
VL - 13
IS - 2
SP - 191
EP - 194
SN - 1225813X
AV - Location: KR; Number: 1998001153
N1 - Database Contributor: AGRIS. Database Contributor ID: KR1998001153. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: KR1998001153. Author Affiliation: Kim, P.Y. : Korea Food and Drug Administration, Seoul Korea Republic . National Institute of Toxicology Research 1; Lee, Y.S. : Seoul National University, Suwon Korea Republic . College of Veterinary Medicine 2;
KW - toxicity
KW - laboratory animals
KW - guinea pigs
KW - toxicite
KW - animal de laboratoire
KW - cobaye
KW - toxicidad
KW - animales de laboratorio
KW - cobaya
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Orlandi, P A
AU - CARTER, L
AU - Brinker, A M
AU - DA'SILVA, A J
AU - Chu, D M
AU - LAMPEL, K A
AU - Monday, S R
TI - Targeting single-nucleotide polymorphisms in the 18S rRNA gene to differentiate Cyclospora species from Eimeria species by multiplex PCR
JO - Applied and Environmental Microbiology
PY - 2003/01/01/
VL - 69
IS - 8
SP - 4806
EP - 4813
PB - American Society for Microbiology [ASM]: 1752 N St., NW, Washington, DC 20036-2904, USA
SN - 00992240
N1 - Note: HEALTHLIT Location: Rhodes University, PO Box 94, Grahamstown, 6140, South Africa. Database Contributor: HEALTHLIT. Database Contributor ID: 254667-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 254667-1. Author Affiliation: [2003] - US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA 1;
AB - HEALTHLIT Abstract: Cyclospora cayetanensis is a coccidian parasite that causes protracted diarrheal illness in humans. C. cayetanensis is the only species of this genus thus far associated with human illness, although Cyclospora species from other primates have been named. The current method to detect the parasite uses a nested PCR assay to amplify a 294-bp region of the small subunit rRNA gene, followed by restriction fragment length polymorphism (RFLP) or DNA sequence analysis. Since the amplicons generated from C. cayetanensis and Eimeria species are the same size, the latter step is required to distinguish between these different species. The current PCR-RFLP protocol, however, cannot distinguish between C. cayetanensis and these new isolates. The differential identification of such pathogenic and nonpathogenic parasites is essential in assessing the risks to human health from microorganisms that may be potential contaminants in food and water sources. Therefore, to expand the utility of PCR to detect and identify these parasites in a multiplex assay, a series of genus- and species-specific forward primers were designed that are able to distinguish sites of limited sequence heterogeneity in the target gene. The most effective of these unique primers were those that identified single-nucleotide polymorphisms (SNPs) at the 3' end of the primer. Under more stringent annealing and elongation conditions, these SNP primers were able to differentiate between C. cayetanensis, nonhuman primate species of Cyclospora, and Eimeria species. As a diagnostic tool, the SNP PCR protocol described here presents a more rapid and sensitive alternative to the currently available PCR-RFLP detection method. In addition, the specificity of these diagnostic primers removes the uncertainty that can be associated with analyses of foods or environmental sources suspected of harboring potential human parasitic pathogens
KW - microbiology / biotechnology
KW - diseases / pathogens
KW - health / public health
KW - Insertae
KW - Sedis
KW - Cyclospora cayetanensis
KW - microbiology / biotechnology
KW - diseases / pathogens
KW - health / public health
KW - Insertae
KW - Sedis
KW - Cyclospora cayetanensis
KW - human health
KW - parasite
KW - human diseases
KW - 18s rrna gene
KW - genetics
KW - gene analysis
KW - parasite detection
KW - methodology
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DP - EBSCOhost
DB - awn
ER -
AU - Jackson, G J
TI - Testing for food-borne parasites, their metabolic products and symbionts
JO - Southeast Asian Journal of Tropical Medicine and Public Health
PY - 1991/01/01/
VL - 22 Su
SP - 334
EP - 336
SN - 01251562
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: QTT17582CB; EC Number: 3.4.23.1. Database Contributor: MEDLINE. Database Contributor ID: 1822919. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 1822919. Author Affiliation: Division of Microbiology, United States Food and Drug Administration, Washington, DC 20204 1;
AB - MEDLINE Abstract: Microscopic animals associated with foods include free-living and saprophytic invertebrates, parasites of hosts other than humans, and parasitic animals specifically designated as food-borne that can infect a human host by the gastrointestinal route. The first general method used to screen for food-borne species was digestion with pepsin and hydrochloric acid at 36 degrees C, based on the "artificial stomach juice" technique for recovering larvae of the nematode Trichinella spiralis from muscle. This method selects for forms capable of surviving a mammalian digestive enzyme at mammalian temperatures. It has been used successfully to recover a variety of food-borne helminths, not only from mammalian flesh but also from fish, shellfish and molluscs, and can be adapted to greatly reduce the "background of living animals" associated with soils and the crops grown in them. However, not all animal forms that survive digestion are food-borne parasites, and all that succumb are not necessarily noninfectious. Methodology to test for food-borne parasites is, in general, not as efficient as that for food-borne bacteria. Recent developments in food parasitology indicate a need to identify not only the parasite, but also its metabolic products and associated symbionts
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DP - EBSCOhost
DB - awn
ER -
AU - Paulsen, H J
TI - Tuberculosis in the native American: indigenous or introduced
JO - Reviews of Infectious Diseases
PY - 1987/01/01/
VL - 9
IS - 6
SP - 1180
EP - 1186
SN - 01620886
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 3321366. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 3321366. Author Affiliation: Clinical Services Branch, U.S. Public Health Service, Seattle, Washington 1;
AB - MEDLINE Abstract: An analysis of the current and historical literature is presented in order to assess the weight of evidence for the existence of tuberculosis among the Native Americans of North America before the time of Columbus. Literature related to pertinent artifacts, biologic specimens, geographic and geologic history, epidemiology, and early travelogues and histories in considered. While the evidence does not convincingly confirm or deny the presence of this disease in America's earliest human history, an understanding of the factors related to the epidemiology of tuberculosis is of value for both social and public health reasons
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DP - EBSCOhost
DB - awn
ER -
AU - Castro, K G
TI - Tuberculosis as an opportunistic disease in persons infected with human immunodeficiency virus
JO - Clinical Infectious Diseases
PY - 1995/01/01/
VL - 21 Su
IS - 1
SP - S66
EP - S71
SN - 10584838
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 8547515. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 8547515. Author Affiliation: Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA 1;
AB - MEDLINE Abstract: Tuberculosis, a bacterial disease caused by the Mycobacterium tuberculosis complex, is becoming an increasingly common opportunistic disease in persons infected with the human immunodeficiency virus (HIV). M. tuberculosis is transmitted from person-to-person by airborne droplet nuclei. Persons who are exposed to these droplet nuclei in poorly ventilated environments are at risk of becoming infected with M. tuberculosis. HIV infection is probably the most significant risk factor associated with progression from latent M. tuberculosis infection to active disease. Thus, HIV-infected persons should avoid exposure to M. tuberculosis, they should be screened for evidence of latent infection with the tuberculin skin test, and they should be offered preventive therapy. Because many severely immunosuppressed anergic HIV-infected persons have been found to have an increased risk of developing active tuberculosis, decisions to use preventive therapy should be individualized on the basis of the local prevalence of tuberculosis and drug-resistance patterns. Persons with active tuberculosis should receive at least 6 months of treatment with recommended regimens, preferably with directly observed therapy, to ensure adequate bacteriologic response, completion of therapy, and cure. Chronic suppressive therapy after completion of therapy is currently not recommended
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DP - EBSCOhost
DB - awn
ER -
AU - Comstock, George W
TI - Tuberculosis studies in Muscogee County, Georgia: I. Community-wide tuberculosis research
JO - American Journal of Epidemiology
PY - 2008/01/01/
VL - 168
IS - 7
SP - 687
EP - 691
SN - 00029262
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database. Database Contributor: MEDLINE. Database Contributor ID: 18820267. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 18820267. Author Affiliation: Field Studies Branch, Division of Tuberculosis, Public Health Service, USA 1;
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DP - EBSCOhost
DB - awn
ER -
AU - Brennan, Michael J
TI - The tuberculosis vaccine challenge
JO - Kekkaku
PY - 2005/01/01/
VL - 85
IS - 1-2
SP - 7
EP - 12
SN - 00229776
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; 0; E-mail: brennan@cber.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 15687021. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15687021. Author Affiliation: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29 Rm 503 HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA 1;
AB - MEDLINE Abstract: Although antibiotic treatments for tuberculosis are available, because of re-infection, drug resistance, AIDS, and economic reasons, it is unlikely that we will be able to control the global spread of tuberculosis without an effective vaccine. A number of new candidate vaccines for tuberculosis are under development and some are being evaluated for safety in normal human subjects in clinical trials. Additional vaccine candidates have been shown to be safe and effective when administered prior to infection in animal models. However, in areas of the world where tuberculosis is endemic, up to two thirds of the population are already infected with Mycobacterium tuberculosis, and it is unlikely that a new pre-exposure vaccine would have a substantial impact on disease for decades. In contrast, a vaccine that could be delivered to individuals already infected could reduce the disease burden. At this time, it is unclear whether the new TB vaccines can be safely and effectively used in populations already infected with M. tuberculosis, immunized with BCG vaccine or infected with HIV. This presents a major challenge to pre-clinical testing and clinical evaluation as well as eventual uptake of the new TB vaccines into areas of the world that are most at risk for tuberculosis
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DP - EBSCOhost
DB - awn
ER -
AU - Roscoe, R J
TI - An update of mortality from all causes among white uranium miners from the Colorado Plateau Study Group
JO - American Journal of Industrial Medicine
PY - 1997/01/01/
VL - 31
IS - 2
SP - 211
EP - 222
SN - 02713586
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 4OC371KSTK; Q74S4N8N1G. Database Contributor: MEDLINE. Database Contributor ID: 9028438. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 9028438. Author Affiliation: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA 1;
AB - MEDLINE Abstract: To place previously recognized mortality risks into the context of the total mortality from all causes, an updated retrospective cohort mortality study was conducted on 3,238 white males from the US Public Health Service cohort of Colorado Plateau uranium miners. Vital status was followed from 1960 through 1990. Life-table analyses used combined New Mexico, Arizona, Utah, and Colorado mortality rates for external comparison and mortality risks within the lowest radon-exposure or duration-employed category for internal comparison. Significantly elevated SMRs were found for pneumoconioses (SMR = 24.1, 95% CI 16.0-33.7), lung cancer (SMR = 5.8, 95% CI 5.2-6.4), tuberculosis (SMR = 3.7, 95% CI 1.9-6.2), chronic obstructive respiratory diseases (SMR = 2.8, 95% CI 2.2-3.5), emphysema (SMR = 2.5, 95% CI 1.9-3.2), benign and unspecified tumors (SMR = 2.4, 95% CI 1.0-4.6), and diseases of the blood and blood-forming organs (SMR = 2.4, 95% CI 1.0-5.0). No significantly lowered SMRs were found for any disease. For lung cancer and pneumoconioses standardized rate ratios increased with increasing exposure to radon progeny or duration of employment. Most findings from this update are consistent with previous studies. Not observed were previously elevated SMRs for chronic nephritis and for acute alcoholism. New findings observed were elevated SMRs for benign and unspecified tumors and for diseases of the blood and blood-forming organs. The most important long-term mortality risks for the white uranium-miners continue to be lung cancer and pneumoconioses, for which SMRs remain significantly elevated after a mean period of 22.4 years since last uranium mining
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DP - EBSCOhost
DB - awn
ER -
AU - Davis, H
TI - Use of computerized health claims data to monitor compliance with antibiotic prophylaxis in sickle cell disease
JO - Pharmacoepidemiology and Drug Safety
PY - 1998/01/01/
VL - 7
IS - 2
SP - 107
EP - 112
SN - 10538569
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; E-mail: davisha@cder.fda.gov. Database Contributor: MEDLINE. Database Contributor ID: 15073734. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 15073734. Author Affiliation: Office of Epidemiology and Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA 1;
AB - MEDLINE Abstract: OBJECTIVE: To demonstrate how computerized claims data can be used to identify children with sickle cell disease probably having low compliance with antibiotic prophylaxis of pneumococcal disease. METHODS: The study included under-5-year-old children with sickle cell disease who were on antibiotic prophylaxis and covered by Medicaid in Michigan (N=158), Missouri (N=64), and New York (N=297). Medicaid pharmacy claims from 10-month periods were used to estimate the total days' supply of antibiotics dispensed for each child. Low compliance was defined as a ratio less than 0.33 for the child's estimated total days' supply of antibiotics divided by days in the child's study period. Two slightly different methods of estimating antibiotic supplies were used to generate a low and high estimate of the percentage of children having low compliance. RESULTS: Low and high estimates of the percentage of children having low compliance were 20% and 25% in Michigan, 19% and 31% in Missouri, and 16% and 24% in New York. With each method of estimating antibiotic supplies, low compliance was not associated with age in any state. CONCLUSIONS: Computerized claims data can be used, potentially by Medicaid programs and managed care organizations, to identify children with sickle cell disease who probably have low compliance with antibiotic prophylaxis
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Williams, J.C.
AU - Peacock, M.G.
AU - Waag, D.M.
AU - Kent, G.
AU - England, M.J.
AU - Nelson, G.
AU - Stephenson, E.H.
TI - Vaccines against Coxiellosis and Q fever: development of a chloroform: methanol residue subunit of phase I Coxiella burnetii for the immunization of animals [Language: en]
JO - New York Academy of Sciences. Annals
PY - 1992/01/01/
VL - 653
SP - 88
EP - 111
SN - 00778923
AV - Location: US; Number: 9315616
N1 - Database Contributor: AGRIS. Database Contributor ID: US9315616. Database Subset: AFRICAN STUDIES. Language: English. Document Type: Article. Publication Type: Journal Article. Accession Number: US9315616. Author Affiliation: Williams, J.C. : Food and Drug Administration, Bethesda, MD 1;
KW - guinea pigs
KW - coxiella
KW - q fever
KW - vaccines
KW - immunization
KW - cobaye
KW - fievre q
KW - vaccin
KW - immunisation
KW - cobaya
KW - fiebre q
KW - vacuna
KW - inmunizacion
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DP - EBSCOhost
DB - awn
ER -
TY - JOUR
AU - Witt, C J
AU - Malone, J L
TI - A veterinarian's experience of the spring 2004 avian influenza outbreak in Laos
JO - The Lancet Infectious Diseases
PY - 2005/01/01/
VL - 5
IS - 3
SP - 143
EP - 145
PB - Elsevier: Elsevier Ltd, c/o BTB Mailflight Ltd, 365 Blair Road, Avenel, NJ 07001, USA
SN - 14733099
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 791034. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Article. Publication Type: Article. Accession Number: 791034. Author Affiliation: 2005 Year - Public Health Service, Antimicrobial Resistance, Department of Defence Global Emergine Infections Systems, MD, USA 1;
KW - Forestry / agriculture
KW - Birds
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Asia
KW - Laos
KW - Thailand
KW - Forestry / agriculture
KW - Birds
KW - Humans
KW - Diseases / pathogens
KW - Health / public health
KW - Asia
KW - Laos
KW - Thailand
KW - disease outbreaks
KW - avian influenza
KW - animal diseases
KW - human diseases
KW - zoonotic impacts
KW - veterinary health surveillance
KW - international co operation
KW - multi disciplinary studies
KW - agricultural workers [cill]
KW - training
KW - protection equipment [cill]
KW - culling
KW - affected animals
KW - poultry [cill]
KW - risks
KW - disease prevention
KW - rural areas
KW - housing [cill]
KW - mountainous area [cill]
KW - subsistence farming
KW - pandemics
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DP - EBSCOhost
DB - awn
ER -
AU - Doveren, R F
TI - Why tuberculosis control in an unstable country is essential: desperate TB patients embrace DOTS in Angola
JO - International Journal of Tuberculosis and Lung Disease
PY - 2001/01/01/
VL - 5
IS - 5
SP - 486
EP - 488
SN - 10273719
N1 - Note: Record Source: This record is provided from the MEDLINE database of the National Library of Medicine (NLM), United States. The index terms may have been modified to conform with terminology used throughout the database; CAS Registry Number: 0; E-mail: doverenr@zeelandnet.nl. Database Contributor: MEDLINE. Database Contributor ID: 11336282. Database Subset: AFRICAN HEALTHLINE. Language: English. Accession Number: 11336282. Author Affiliation: Public Health Service Rotterdam, Department of Infectious Diseases, The Netherlands 1;
AB - MEDLINE Abstract: After decades of war, the tuberculosis situation in Angola is alarming. The author describes his experiences with the implementation of a DOTS TB programme adapted to the difficult circumstances in a town partly inhabited by displaced people. The high motivation of both patients and health care workers is an important factor for its successful implementation. The need for international support of tuberculosis control programmes also in war-ridden countries is stressed
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ER -
AU - Yassien, C.M. abd el Latif
TI - Implementation strategies and biogas technologies applied in Egypt [Language: en]
PY - 1990/01/01/
PB - GTZ
AV - Location: DE; Number: 91Q2249
N1 - Note: Report of International Conference on Biogas - technologies and implementation strategies, Bremen Overseas Research and Development Association, Bremen (Germany).- Eschborn (Germany): GTZ, 1990. p. 271-286. Database Contributor: AGRIS. Database Contributor ID: DE91Q2249. Database Subset: AFRICAN STUDIES. Language: English. Publication Type: Conference / Proceedings. Place of Publication: Eschborn, Germany. Conference: International Conference on Biogas. Technologie and Implementation Strategies. Conference Date: 10-15 Jan 1990. Conference Location: Pune (India). Accession Number: DE91Q2249. Author Affiliation: Yassien, C.M. abd el Latif : National Institute of Occupational Safety and Health Egypt . General Manager of Occupational Hygiene Dept 1;
KW - egypt
KW - biogas
KW - energy sources
KW - wastes
KW - digesters
KW - developing countries
KW - egypte
KW - biogaz
KW - source d'energie
KW - dechet
KW - digesteur
KW - pays en developpement
KW - egipto
KW - fuente de energia
KW - desechos
KW - digestores
KW - paises en desarrollo
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TY - CHAP
AU - Bennett, R W
AU - Monday, S R
TI - 4. Staphylococcus aureus
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 41
EP - 60
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249155-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249155-1. Author Affiliation: 2003 Year - U.S. Food and Drug Administration, College Park, Maryland, USA 1;
KW - health / public health
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KW - Staphylococcus aureus
KW - health / public health
KW - bacteria / fungi / viruses
KW - food / diet
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KW - genetics / strains / stock identification
KW - Medical science
KW - Bacteria
KW - Staphylococcus aureus
KW - food borne diseases
KW - disease control
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KW - epidemiology
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TY - CHAP
AU - Datta, A R
TI - 7. Listeria monocytogenes
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 105
EP - 121
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249160-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249160-1. Author Affiliation: 2003 Year - US Food and Drug Administration, Rockville, Maryland, USA 1;
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TY - CHAP
AU - HANES, D
TI - 9. Nontyphoid Salmonella
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 137
EP - 149
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249162-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249162-1. Author Affiliation: 2003 Year - U S Food and Drug Administration, Laurel, Maryland, USA 1;
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KW - Enterobacteriaceae
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TY - CHAP
AU - Hu, L
AU - Kopecko, D J
TI - 10. Typhoid Salmonella
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 151
EP - 165
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249163-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249163-1. Author Affiliation: 2003 Year - US Food and Drug Administration, Bethesda, Maryland, USA 1;
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KW - Enterobacteriaceae
KW - Salmonella typhi
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KW - pathogen identification
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KW - toxicity
KW - enteric fever
KW - water pollution
KW - typhoid
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TY - CHAP
AU - LAMPEL, K A
AU - Maurelli, A T
TI - 11. Shigella species
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 167
EP - 180
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
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N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249164-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249164-1. Author Affiliation: 2003 Year - US Food and Drug Administration, Washington, D C, USA 1;
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KW - Shigella spp
KW - Enterobacteriaceae
KW - Shigella flexneri
KW - food / diet
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KW - bacteria / fungi / viruses
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KW - Enterobacteriaceae
KW - Shigella spp
KW - Enterobacteriaceae
KW - Shigella flexneri
KW - food borne diseases
KW - disease control
KW - food contamination
KW - epidemiology
KW - disease symptoms
KW - pathogen identification
KW - virulence
KW - toxicity
KW - bacillary dysentry
KW - shigellosis
KW - diarrhoea
KW - genetic studies
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TY - CHAP
AU - Hu, L
AU - Kopecko, D J
TI - 12. Campylobacter species
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 181
EP - 198
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249165-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249165-1. Author Affiliation: 2003 Year - US Food and Drug Administration, Bethesda, Maryland, USA 1;
KW - health / public health
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KW - Campylobacter coli
KW - Insertae
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KW - Campylobacter jejuni
KW - health / public health
KW - bacteria / fungi / viruses
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KW - Medical science
KW - genetics / strains / stock identification
KW - Insertae
KW - Sedis
KW - Campylobacter coli
KW - Insertae
KW - Sedis
KW - Campylobacter jejuni
KW - food borne diseases
KW - disease control
KW - food contamination
KW - epidemiology
KW - disease symptoms
KW - pathogen identification
KW - virulence
KW - toxicity
KW - enteritis
KW - diarrhoea
KW - water pollution
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ER -
TY - CHAP
AU - CLERGE, G
AU - ERIBO, B E
AU - TALL, B D
TI - 16. Fibrio vulnificus
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 253
EP - 294
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249169-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249169-1. Author Affiliation: 2003 Year - afety Research Unit, 1200 N. DuPont Highway, WW Baker Center, Delaware State University, Dover DE 19901 1; JIFSAN, US FDA Washington, DC 20204 2; US Food and Drug Administration, Washington, DC USA 3;
KW - health / public health
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KW - microbiology / biotechnology
KW - Vibrionaceae
KW - Vibrio vulnificus
KW - health / public health
KW - bacteria / fungi / viruses
KW - food / diet
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KW - toxicology / toxicity
KW - biochemistry / molecular biology
KW - microbiology / biotechnology
KW - Vibrionaceae
KW - Vibrio vulnificus
KW - food borne diseases
KW - disease control
KW - food contamination
KW - epidemiology
KW - disease symptoms
KW - pathogen identification
KW - virulence
KW - toxicity
KW - wound infections
KW - tissue adherence
KW - genetic studies
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ER -
TY - CHAP
AU - Wood, G E
AU - Trucksess, M W
AU - Henry, S H
TI - 24. Major fungal toxins of regulatory concern
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 423
EP - 443
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
SN - 0-8247-0685-4
N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249178-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249178-1. Author Affiliation: 2003 Year - US Food and Drug Administration, College Park, Maryland, USA 1;
KW - health / public health
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KW - Aspergillus parasiticus
KW - Insertae
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KW - Penicillium spp
KW - Insertae
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KW - Aspergillus flavus
KW - Insertae
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KW - Fusarium spp
KW - Insertae
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KW - health / public health
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KW - Insertae
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KW - food borne diseases
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KW - pathogen identification
KW - virulence
KW - toxicity
KW - fungal diseases
KW - aflatoxons
KW - ochratoxins
KW - deoxynivalenol
KW - fumonisins
KW - zearalenone
KW - patulin
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TY - CHAP
AU - CRAWFORD, L
TI - 50. The Office International des Epizooties Part II
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 793
EP - 797
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
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N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249203-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249203-1. Author Affiliation: 2003 Year - y of Agricultural Sciences), Uppsala, Sweden 1; Western Regional Research Laboratory, Agricultural Research Service, US Department of Agriculture, Berkeley, CA 94710, USA 2; US Food and Drug Administration, Rockville, Maryland, USA 3;
KW - health / public health
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KW - disease prevention
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TY - CHAP
AU - HOSKIN, G P
AU - JONES, W R
AU - Podoski, B
AU - Bluhm, L
TI - 52. Hazard analysis and critical control point systems
JO - International Handbook of Foodborne Pathogens
PY - 2003/01/01/
SP - 815
EP - 824
PB - Marcel Dekker Inc.: 270 Madison Avenue, New York, NY 10016, USA
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N1 - Database Contributor: HEALTHLIT. Database Contributor ID: 249205-1. Database Subset: AFRICAN HEALTHLINE. Language: English. Document Type: Book Entry. Publication Type: Book Chapter / Report Section. Accession Number: 249205-1. Author Affiliation: 2003 Year - Rockville, Maryland, USA 1; Office of Seafood, US Food and Drug Administration, 200 C Street, SW Washington, DC 20204,USA 2; US Food and Drug Administration, College Park, Maryland, USA 3;
KW - food / diet
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KW - sanitation requirements
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ER -
TY - GEN
T1 - Disease-bearing Mosquitos of North and Central America, the West Indies, and the Philippine Islands.
AU - LUDLOW, C. S.
T2 - War Dept
JO - War Dept
JF - War Dept
Y1 - 1913///
IS - Bull. 4
SP - 97
EP - 97
AD - LUDLOW, C. S.: Office of the Surgeon-General, Washington, D.C.
N1 - Accession Number: 19141000235. Publication Type: Miscellaneous. Language: not specified.
N2 - The following mosquitos are recorded as carriers of malaria and other diseases: -Anopheles crucians, Wied., widely distributed in North America; A. maculipennis, Meig., Europe, Canada, U.S.A. ; A. (Myzomyia) rossi, Giles, India and the Philippines, host for Filaría bancroflii, but probably negative to malaria; A. funesta, Giles, Tropical Africa and the Philippines; A. (Cycloleppteron) gmbhamii, Theo., Jamaica; A. (Myzorhynchus) sinensis, Wied., Formosa, China and the Philippines; A. barbirostris, Van der Wulp. Selangor, Upper Burma, and the Philippines; reported to be experimentally positive to malaria; A. (Nyssorhynchus) fuliginosus, Giles, India and the Philippines; A. (Cellia) argyrotarsis, Rob., West Indies, Brazil, Canal Zone, etc., also carries Filaria nocturna; A. albimana, Wied., West Indies, Brazil, Canal Zone, India, etc. ; A, tarsimaculata, Canal Zone, Central America, and southward; Stegomyia fasciata [Aedes aegypti], F., of world-wide distribution in the Tropics, carrying yellow fever; Culex fatigans [Culex quinquefasciatus], Wied., all over the world, a host for Filaría nocturna, and concerned in the transmission of dengue; Mansonioides uniformis [Mansonia uniformis], Theo., South India, Perak, Philippines, positive to Filaria nocturna in Africa; and Mansonioides africanus, Theo., Tropical Africa and the Philippines, perhaps also positive to F. nocturna. The following species are referred to as being probably negative to malaria: -A. punctipennis, Say, A. indefinita, Ludl., and probably A. kochi, Don. A. pseudopunctipennis, Theo., and A.franciscanus, McC., are most probably, but not certainly, carriers of malaria. Particulars are also given of a number of doubtful species, including ludlowii, Theo., and many others, the relations of which to malaria are unknown.
KW - carrier state
KW - dengue
KW - filariids
KW - human diseases
KW - islands
KW - malaria
KW - tropics
KW - yellow fever
KW - Africa South of Sahara
KW - America
KW - Brazil
KW - Canada
KW - Caribbean
KW - Central America
KW - China
KW - Europe
KW - India
KW - Jamaica
KW - Myanmar
KW - North America
KW - Philippines
KW - Taiwan
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Anopheles
KW - Anopheles barbirostris
KW - Anopheles crucians
KW - Anopheles culicifacies
KW - Anopheles maculipennis
KW - Anopheles pseudopunctipennis
KW - Anopheles punctipennis
KW - Culex
KW - Culex quinquefasciatus
KW - Culicidae
KW - man
KW - Mansonia (Diptera)
KW - Mansonia africana
KW - Mansonia uniformis
KW - Plasmodium
KW - yellow fever virus
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culex
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Mansonia (Diptera)
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Africa
KW - South America
KW - America
KW - Developing Countries
KW - Threshold Countries
KW - Latin America
KW - North America
KW - Developed Countries
KW - Commonwealth of Nations
KW - OECD Countries
KW - East Asia
KW - Asia
KW - South Asia
KW - Greater Antilles
KW - Caribbean
KW - ACP Countries
KW - Caribbean Community
KW - South East Asia
KW - Least Developed Countries
KW - ASEAN Countries
KW - Burma
KW - Formosa
KW - Mansonia
KW - mosquitoes
KW - tropical countries
KW - tropical zones
KW - United States of America
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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ER -
TY - JOUR
T1 - Activities of Plankton in the Natural Purification of Polluted Water.
AU - PURDY, W. C.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1928///
VL - 18
SP - 468
EP - 75
SN - 0090-0036
AD - PURDY, W. C.: U.S. Public Health Service, Cincinnati, O.
N1 - Accession Number: 19282701582. Publication Type: Journal Article. Language: not specified. Number of References: 1 ref.
N2 - The author states that as a rule plankton and related organisms are most abundant in water which is in process of recovery from pollution by sewage; that is during natural purification, and he groups his observations under the head of three questions which he endeavours to answer by proof. The questions are: - 1. Are the activities of these organisms a part of natural purification? 2. What effects, if any, are produced on water by the presence and activities of these minute forms of life? 3. What are some of the activities? The activities of the plankton organisms are chiefly concerned with obtaining food and reproduction of species, the matter of food supply being dominant, and are discussed under the heads of (1) plankton food (2) photosynthesis, (3) expenditure of plankton energy. A noted German investigator some years ago classified all plankton organisms as " food producers, " and " food consumers " including in the latter those organisms which by means of cilia swept bacteria etc. into their mouth vacuoles. Observers in general have noted certain plankton forms to be always present and associated with sewage and their decrease or absence when the bacterial content becomes low. In three rivers thus far studied (Potomac, Ohio and Illinois) these pollutional organisms are most numerous in that part of the stream where pollution is physically evident and decrease as the water regains normal conditions. There is ample laboratory evidence that these organisms are able to consume large quantities of bacteria, the plankton increasing greatly in numbers, the results being based on the following tests: - 1. Sterilized sewage, inoculated with bacteria only, reached a very high count of bacteria in 4 to 6 days and maintained this for 6 to 10 weeks. 2. Sterilized sewage, inoculated with bacteria and also with pollutional protozoa showed high bacterial maximum in 4 to 6 days, then heavy and rapid reduction with rapid increase in protozoa about the time of greatest bacterial decrease. For example paramecia will not thrive in a sterilized sewage but when bacteria are present they increase enormously, bacteria decreasing pro rata. Another organism (Colpidium) fails to live in sterilized sewage without bacteria added, although it will live in sterile water to which bacteria have been added, indicating that bacteria are necessary for its existence. Photosynthesis. The chlorophyll-bearing organisms of the plankton dissociate 'carbon dioxide and liberate oxygen in the presence of sunlight. Unless the water is already saturated this oxygen will be dissolved to some extent and may be utilized in the aerobic decomposition of organic matter. No experimental data are available but the author suggests that even in a polluted river like the Illinois River the major part of the plankton, volume for volume, is of the chlorophyll-bearing, oxygen-producing sort, and the opinion is ventured that adequate study of this unique activity of the plankton may result in a rating as to its significance in the progress of natural purification.Expenditure of Energy.Under the microscope plankton activity is most apparent by its physical movement due to the activity of the cilia, which causes local disturbance of the water and causes a mixing up of the various parts of the water. In polluted water various motile forms in large quantities and in a very active state, and fixed forms with cilia at their free ends cause a mixing of the waters, as the numbers are great and a complete and intimate mixture of 1 cc. of water is possible in 1 minute. What is the probable effect of this continuous mixing and microscopic circulation? In the absence of experimental evidence or data it suggests the probability of it being a factor in purification. In the laboratory, cultures of sewage containing only bacteria retain their foul odour and milky turbidity for 8 weeks or more whilst like cultures which contain active protozoa in addition to bacteria lost their turbidity and odour in about 10 days. Apparently the organic matter that constitutes the pollution of water constitutes also the food of certain plankton organisms which are numerous; thus a portion of this polluting organic matter of the water reappears as a multitude of minute organisms whose rapid and continuous movements represent the energy of the organic food consumed. Correlation of energy is effected and the polluted water is started on the road to recovery. The movement of the larger organisms, in attacking masses of organic matter, and their activity in the bottom of the sediments (e.g. Cypris, a plankton crustacean) works the surface of the sediment over and over until this is reduced to a state of microscopic fineness. Certain worms also work in the sediment excavating beneath the mud and depositing it upon the surface. The author summarizes his paper by stating that, in his opinion, the activities of plankton and related organisms constitute a part of the programme of natural purification of polluted waters, in that their food habits tend to remove a portion of the organic matter, the photo-synthetic activities of the chlorophyll-bearing organisms operate to produce oxygen, and the energy of harmful organic matter consumed as food and released to the water in terms of motion serves to furnish an intimate mixing and microscopic circulation during the critical initial stages of recovery from pollution. W. Rushton.
KW - feeding habits
KW - food supply
KW - photosynthesis
KW - plankton
KW - pollution
KW - purification
KW - reproduction
KW - rivers
KW - sewage
KW - solar radiation
KW - water pollution
KW - Illinois
KW - Ohio
KW - USA
KW - Crustacea
KW - Cypris
KW - Protozoa
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cyprididae
KW - Podocopa
KW - Ostracoda
KW - Crustacea
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Corn Belt States of USA
KW - carbon assimilation
KW - carbon dioxide fixation
KW - eating habits
KW - environmental pollution
KW - sunlight
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Aquatic Biology and Ecology (MM300)
KW - Pollution and Degradation (PP600)
KW - Human Wastes and Refuse (XX300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19282701582&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Sex Differences in the Incidence of. Certain Diseases at Different Ages. Hagerstown Morbidity Studies No. IX.
AU - SYDENSTRICKER, E.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1928///
VL - 43
SP - 1259
EP - 76
PB - Wash
SN - 0033-3549
AD - SYDENSTRICKER, E.: Office of Statistical Investigations, U.S. Public Health Service, Washington, D.C.
N1 - Accession Number: 19282702423. Publication Type: Journal Article. Language: not specified. Number of References: 4 ref.
N2 - Since, in this study, the informant as to illness was usually the housewife, there is considerable risk that minor ailments manifested by subjective symptoms would be more completely reported for the informant than for other members of the household. The data had to be treated in various ways so as to minimize this possible effect-by using only diseases manifested in objective ways, by dealing with non-adults, etc. The incidence of infectious diseases was found to be higher among boys than among girls below age 10 [the difference is small and of doubtful significance], while above that age the female rate is always above that for the male. In diseases of the skin boys also are at a disadvantage. Diseases of the ears and eyes show no material differences. The respiratory illness rate and that for diseases and conditions, of the nervous system were higher among females in every age period except under 10 years. The adult female illness rate from digestive causes .was about 80 to 100 per cent. above the male rate. The only definite exception to this female excess over the male rates is to be found in the accident rate. [Single and married women are not treated separately. In the English experience, as regards working women at least, sickness-incidence varies strikingly with civil state. The sex difference is discussed only with regard to number of attacks and not-in this report-with regard to duration of attacks.] A. B. Hill.
KW - boys
KW - children
KW - disease prevalence
KW - ears
KW - eyes
KW - girls
KW - households
KW - human diseases
KW - incidence
KW - infectious diseases
KW - morbidity
KW - nervous system
KW - respiratory diseases
KW - sex differences
KW - symptoms
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - lung diseases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Demography (UU200)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Sterilizing Action of Repeated, Fractional Doses of Arsphenamine in Experimental Syphilis.
AU - VOEGTLIN, C.
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
Y1 - 1929///
VL - 35
SP - 189
EP - 92
SN - 0022-3565
AD - VOEGTLIN, C.: Hyg. Lab., U.S. Public Health Service, Washington.
N1 - Accession Number: 19302700800. Publication Type: Journal Article. Language: not specified. Number of References: 4 ref. Registry Number: 457-60-3, 139-93-5, 637-03-6.
N2 - In a previous paper Voegtlin and DYER showed that syphilitic rabbits could be sterilized by a single dose of an arsenobenzene compound, the dose depending on the arsenical content. As the sterilizing dose in mgm. per kgm. was greater than would be employed in the case of man, Voegtlin has now carried out further experiments to see if repeated doses which are fractions of the single sterilizing dose will sterilize. Twenty-four rabbits were infected and divided into four groups of six each, On the 55th day of the disease six received 24 mgm. ' 606 ' per kgm. ; six commenced a course of 2 injections, six days apart, of 12 mgm. per kgm. ; six had a course of 4 injections, at the same intervals, of 6 mgm. per kgm. and six a course of 2 injections, six days apart, of 6 mgm. per kgm. The animals were tested by the gland transfer method about two months later, and the results showed 5 out of 6 sterilized in the first two groups, all in the 3rd, but only 2 out of 6 in the 4th. The author expresses a hope that more work on similar lines will be done on clinical material, transferring lymph glands to rabbits. [In the author's previous experiments the single sterilizing doses of arsphenamine, neoarsphenamine and sulph-arsphenamine were ascertained. Since the two latter are not retained so long in the body as is ' 606 ' it would be interesting to learn if, in the same conditions, 4 doses of neoarsphenamine and of sulpharsphenamine each containing an equivalent amount of As to that in 6 mgm. ' 606 ' per kgm. would have the same effect.] L. W. Harrison.
KW - arsenicals
KW - effects
KW - human diseases
KW - neoarsphenamine
KW - syphilis
KW - therapy
KW - man
KW - rabbits
KW - Treponema pallidum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - small mammals
KW - Treponema
KW - Treponemataceae
KW - Spirochaetales
KW - Gracilicutes
KW - bacteria
KW - prokaryotes
KW - arsenic compounds
KW - arsphenamine
KW - oxophenylarsine
KW - single dose treatment
KW - therapeutics
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19302700800&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - A Study of Negro Infant Mortality.
AU - STOUGHTON, Amanda L.
AU - GOVER, Mary.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1929///
VL - 44
SP - 2705
EP - 31
PB - Wash
SN - 0033-3549
AD - STOUGHTON, Amanda L.: Office of Statistical Investigations in Cooperation with Field Investigations of Child Hygiene, U.S. Public Health Service, Washington.
N1 - Accession Number: 19302701270. Publication Type: Journal Article. Language: not specified. Number of References: 1 ref.
N2 - A comparison of the causes and trend of infant mortality among negro and white infants in selected districts of the United States. Negro rates in every area studied are higher than the corresponding rates for white infants, but the secular changes are, on the whole, similar among the white and coloured populations of the same community. In individual causes of death the negro rate is in excess except for four contagious diseases. The greatest excesses are found in the groups of unknown and ill-defined causes, respiratory diseases, all forms of tuberculosis and gastro-intestinal diseases. Mortality in the first month of life, chiefly due to premature birth and congenital debility, is very much alike in the two groups of infants. The trends of infant mortality from certain causes in the two races were compared in the State of Maryland, and it was found that the decline in diarrhoea and tuberculosis, present in both races, has been more rapid in the white population, and that there has been little improvement for either race in the rates from diseases of early infancy. P. L. McKinlay.
KW - blacks
KW - causes of death
KW - diarrhoea
KW - human diseases
KW - infant mortality
KW - infants
KW - mortality
KW - prematurity
KW - respiratory diseases
KW - tuberculosis
KW - Maryland
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Firmicutes
KW - bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - death rate
KW - diarrhea
KW - lung diseases
KW - scouring
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19302701270&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Mortality from Influenza and Pneumonia in 50 Large Cities of the United States, 1910-1929.
AU - COLLINS, S. D.
AU - FROST, W. H.
AU - COVER, Mary
AU - SYDENSTRICKER, E.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1930///
VL - 45
SP - 2277
EP - 328
PB - Wash
SN - 0033-3549
AD - COLLINS, S. D.: Office of Statistical Investigations, U.S. Public Health Service, Washington.
N1 - Accession Number: 19312700589. Publication Type: Journal Article. Language: not specified. Number of References: 4 ref.
N2 - The statistics of deaths from influenza and pneumonia are examined for 35 large cities of the United States over a period of 20 years, weekly rates being available from 1918 to 1929 and monthly rates from 1910 to 1918. Using various median rates as norms, the direction and extent of deviations from the norm are measured and discussed, being illustrated graphically, both for the whole group of 35 cities and for each city individually (50 separate cities are given). The excess mortality caused by various epidemics is computed and compared. A. B. Hill.
KW - epidemics
KW - human diseases
KW - influenza
KW - mortality
KW - pneumonia
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - death rate
KW - flu
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Demography (UU200)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Functional and histological studies of the effect of fat ingestion upon the normal and damaged liver.
AU - ROSENTHAL, Sanford M.
AU - LILLIE, Ralph D.
JO - American Journal of Physiology
JF - American Journal of Physiology
Y1 - 1931///
VL - 97
SP - 131
EP - 141
SN - 0002-9513
AD - ROSENTHAL, Sanford M.: Div. Pharmacol., Pathol. and Bacteriol., National Inst. of Health, US Public Health Service, Washington.
N1 - Accession Number: 19311400674. Publication Type: Journal Article. Language: not specified. Number of References: 4 tables, 2 charts, 4 photographs, 17 ref.
N2 - Spontaneous and experimental lipæmia causes a slight impairment of liver activity in dogs as shown by a 5-11 per cent. retention of bromsulphonphthalein in the blood fifteen minutes after injection of the dye. There is no increase in urinary urobilinogen nor in blood bilirubin. The retention of dye increases to 20-40 per cent when the liver has been previously damaged with chloroform or carbon tetrachloride, Splenectomy and reticulo-endothelial cell blockade scarcely affect the removal of dye from blood. No appreciable amount of fat is taken up by the Kupffer cells on feeding with cream for one to twenty days. No correlation can be made between the amount of fat in the bile duct epithelium and the diet in dogs on a high-or low-fat diet or during starvation. P. W. Clutterbuck.
KW - bile
KW - blood
KW - cream
KW - epithelium
KW - fat
KW - feeding
KW - histology
KW - liver
KW - meat
KW - milk products
KW - research
KW - retention
KW - starvation
KW - urine
KW - dogs
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - dairy products
KW - fat intake
KW - gall
KW - studies
KW - Pets and Companion Animals (LL070)
KW - Meat Produce (QQ030)
KW - Milk and Dairy Produce (QQ010)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Preliminary studies on aminoacid toxicity and amino-acid balance.
AU - SULLIVAN, M. X.
AU - HESS, W. C.
AU - SEBBELL, W. H.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1931///
VL - 92
SP - lxvii
EP - lxvii
SN - 0021-9258
AD - SULLIVAN, M. X.: Nat. Inst. Health, U.S. Public Health Service. Washington.
N1 - Accession Number: 19311400813. Publication Type: Journal Article. Language: not specified. Registry Number: 56-89-3, 60-18-4.
N2 - Cystine was used to supplement a diet just inadequate in protein. At a 0.5 per cent. level good growth resulted. At 5 per cent. toxicity appeared. Tyrosine was a satisfactory supplement at 2.5 per cent. level but toxic at 5 per cent. C. M. Burns.
KW - cystine
KW - research
KW - toxicity
KW - tyrosine
KW - studies
KW - Animal Nutrition (General) (LL500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19311400813&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Decomposition of lecithin in eggs.
AU - MITCHELL, L. C.
JO - Journal of the Association of Official Agricultural Chemists
JF - Journal of the Association of Official Agricultural Chemists
Y1 - 1932///
VL - 15
SP - 282
EP - 284
AD - MITCHELL, L. C.: Chicago Stat., U.S. Food and Drug Administration.
N1 - Accession Number: 19321401030. Publication Type: Journal Article. Language: not specified.
N2 - An unusually rapid decomposition in egg is shown to be due to bacterial destruction of lecithin.-P. W. Clutterbuck.
KW - eggs
KW - Eggs and Egg Products (QQ040)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The extraction of the antineuritic vitamin (vitamin B1) from dried brewers' yeast.
AU - SEIDELL, A.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1933///
VL - 100
SP - 195
EP - 203
SN - 0021-9258
AD - SEIDELL, A.: Nat. Inst. Health. U.S. Public Health Service, Washington.
N1 - Accession Number: 19331400258. Publication Type: Journal Article. Language: not specified. Registry Number: 64-17-5, 59-43-8.
N2 - An attempt was made to obtain a Fuller's earth vitamin-adsorption product containing less co-adsorbed material than one prepared from an aqueous extract of yeast, On extracting dried brewer's yeast with aqueous solvents containing more than 50 per cent. methyl alcohol, ethyl alcohol or acetone, the quantity of solids and of antineuritic vitamin removed depended principally upon the concentration and not upon the nature of the solvent used. The water was apparently the active extracting agent, the organic constituent preventing hydration and softening of the yeast. Addition of HC1 to the solvent resulted in an increase of vitamin and a greater increase in the other extracted yeast solids. The solvent finally recommended is 70 per cent. methyl alcohol, ethyl alcohol or acetone, acidified with 1 per cent. HC1. This extracts approximately 80 per cent. of the vitamin and only 10 per cent. of the yeast solids. A table is included showing that commercial dried brewer's yeasts may vary by 10 times in their antineuritic content. The latter diminishes slowly on keeping. V. B. Walker.
KW - brewers' yeast
KW - ethanol
KW - extracts
KW - thiamin
KW - vitamins
KW - yeasts
KW - Eumycota
KW - fungi
KW - eukaryotes
KW - aneurin
KW - ethyl alcohol
KW - thiamine
KW - vitamin B1
KW - Microbial Technology in Food Processing (QQ120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19331400258&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The differential extraction from dried brewers' yeast of the antineuritic (vitamin Br) and growth-promoting (vitamin B2) vitamins and their biological standardization. With a note on the relation of hemin to vitamin B2.
AU - SMITH, M. I.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1933///
VL - 100
SP - 225
EP - 235
SN - 0021-9258
AD - SMITH, M. I.: Nat. Inst. Health, U.S. Public Health Service, Washington.
N1 - Accession Number: 19331400259. Publication Type: Journal Article. Language: not specified. Registry Number: 64-17-5, 83-88-5.
N2 - By percolation of brewer's yeast with different solvents it was found that 76 per cent. ethyl alcohol or 70 per cent. acetone, with 1 per cent. HC1, removed 80 per cent. or more of the available vitamin B1; without removing appreciable quantities of vitamin Ba. Addition of more HC1 to the alcohol or acetone, or their further dilution with water, increased the solubility of both vitamins. Methyl alcohol was unsatisfactory, failing to differentiate between the two vitamins. Neither haemin nor haematin was able to provide the thermostable growth factor (vitamin B2) or the antidermatitis factor for rats.-V. B. Walker.
KW - animal models
KW - brewers' yeast
KW - ethanol
KW - growth factors
KW - riboflavin
KW - standardization
KW - vitamins
KW - yeasts
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Eumycota
KW - fungi
KW - ethyl alcohol
KW - vitamin B2
KW - Animal Models of Human Nutrition (VV140)
KW - Microbial Technology in Food Processing (QQ120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19331400259&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Notes on experimental rheumatic fever.
AU - STIMSON, A. M.
AU - HEDLEY, O. F.
AU - ROSE, E.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1934///
VL - 49
SP - 361
EP - 363
SN - 0033-3549
AD - STIMSON, A. M.: Office Heart Dis. Invest., U.S. Public Health Service, Washington.
N1 - Accession Number: 19341400253. Publication Type: Journal Article. Language: not specified.
N2 - The production of cardiac lesions by the injection of streptococcic toxin into scorbutic guineapigs is reported. These lesions resemble closely some stages of human rheumatic heart disease. See also preceding Absts.-A. M. Copping.
KW - animal models
KW - bacterial diseases
KW - heart
KW - heart diseases
KW - human diseases
KW - injection
KW - lesions
KW - rheumatic fever
KW - toxins
KW - guineapigs
KW - man
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - bacterial infections
KW - bacterioses
KW - coronary diseases
KW - guinea pigs
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19341400253&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Distribution and specificity of helminths in microtine rodents: evolutionary implications.
AU - RAUSCH, R.
JO - Evolution
JF - Evolution
Y1 - 1957///
VL - 11
IS - 3
SP - 361
EP - 368
PB - Lancaster, Pa
SN - 0014-3820
AD - RAUSCH, R.: Arctic Health Research Center, U.S. Public Health Service, Anchorage, Alaska.
N1 - Accession Number: 19600801340. Publication Type: Journal Article. Language: not specified.
N2 - The author reviews the taxonomic status of anoplocephaline cestodes of microtine rodents (lemmings and voles) and discusses some of the evolutionary and zoogeographical implications of distribution and host-occurrence of these and other helminths. Of the genus Andrya Railliet, 1883, five species are considered valid: A. macrocephala Douthitt, 1915; A.primordialis Douthitt, 1915; A. montana Kirshenblat, 1941; A. árctica Rausch, 1952; and A. bdrdi Schad, 1954. Of the genus Paranoplocephala Luehe, 1910, six species are regarded as valid: P. omphalodes (Hermann, 1783); P. blanchardi (Moniez, 1891); P. infrequens (Douthitt, 1915); P. variabilis (Douthitt, 1915); P. lemmi Rausch, 1952; and P. neofibrinus Rausch, 1952. Andrya caucásica Kirshenblat, 1938 and A. bialowizensis Soltys, 1949, are regarded as synonyms of P. infrequens. Three species, A. macrocephala, P. omphalodes and P. infrequens are holarctic in distribution, occurring mainly in species of Microtus. The uniformity of microtine rodents as hosts for various helminths is discussed. It is concluded that Dicrostonyx is the most isolated genus from this standpoint, having two nematodes which have not been recorded from members of other genera, and harbouring few helminths in common with others. From the present concept of Pleistocene glaciations, it is concluded that P. omphalodes and P. infrequens reached the St. Matthew Islands, Bering Sea, as parasites of a vole from which Microtus abbreviatus has evolved. It appears that this vole arrived on these islands before North America was invaded, in the late Pleistocene, by the palaearctic M. oeconomus and Clethrtonomys rutilus. The present known distribution of P. omphalodes in North America corresponds roughly to that of M. oeconomus in that continent. W. M. Fitzsimmons.
KW - evolution
KW - helminths
KW - islands
KW - parasites
KW - synonyms
KW - taxonomic status
KW - taxonomy
KW - zoogeography
KW - America
KW - Bering Sea
KW - Montana
KW - North America
KW - USA
KW - Andrya
KW - Anoplocephalidae
KW - Cestoda
KW - Microtus
KW - Nematoda
KW - rodents
KW - voles
KW - Anoplocephalidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Microtinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - small mammals
KW - Northwest Pacific
KW - Pacific Ocean
KW - Northeast Pacific
KW - oceans
KW - marine areas
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Great Plains States of USA
KW - animal geography
KW - parasitic worms
KW - systematics
KW - United States of America
KW - Taxonomy and Evolution (ZZ380)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19600801340&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Characteristics of sodium pentachlorophenate used against Australorbis glabratus French in Puerto Rico.
AU - KLOCK, J. W.
AU - GERHARDT, C. E.
AU - ILDEFONSO, V.
AU - MATEO SERRANO, T.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1957///
VL - 16
IS - 6
SP - 1189
EP - 1201
SN - 0042-9686
AD - KLOCK, J. W.: Communicable Disease Center, U.S. Public Health Service, Department of Health, Education and Welfare, Atlanta, Ga, U.S.A.
N1 - Accession Number: 19600800855. Publication Type: Journal Article. Language: not specified. Registry Number: 131-52-2.
N2 - Klock et al. report the results of investigations into the use of sodium pentachlorophenate as a molluscicide in Puerto Rico. Preliminary laboratory tests indicated that two ranges of concentration, namely, 3-15 p.p.m. and 100-200 p.p.m., were economically preferable for field application. Field trials showed that concentrations of 15 p.p.m. for 125 p.p.m.-hours proved most satisfactory, and that 100% kill of eggs was obtained by doubling the exposure time needed to kill the adult snails. Experiments using the molluscicide compacted into solid masses suggested that this method of treatment is only suitable for slow moving or impounded waters. Supplementary marginal spraying of the habitats is recommended. Laboratory studies revealed that a lethal dose of molluscicide could penetrate the shell of the snails without actually coming into direct contact with the soft parts of the animal's body. C. A. Wright GENERAL HELMINTHOLOGY Technique See also Nos. : 482, 502, 509, 526, 544, 604, 609, 611, 626, 725, 753, 754, 755, 762, 831.
KW - aquatic animals
KW - field tests
KW - freshwater molluscs
KW - helminthology
KW - helminths
KW - molluscicides
KW - sodium pentachlorophenoxide
KW - spraying
KW - Puerto Rico
KW - Biomphalaria
KW - Biomphalaria glabrata
KW - Mollusca
KW - snails
KW - Planorbidae
KW - Gastropoda
KW - Mollusca
KW - invertebrates
KW - animals
KW - snails
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Biomphalaria
KW - Greater Antilles
KW - Caribbean
KW - America
KW - Developing Countries
KW - Latin America
KW - parasitic worms
KW - PCP-Na
KW - Porto Rico
KW - sodium pentachlorophenate
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Schistosoma mansoni infection in two Puerto Rican prisoners.
AU - BRESLAW, L.
JO - ADOals of Internal Medicine
JF - ADOals of Internal Medicine
Y1 - 1958///
VL - 49
IS - 6
SP - 1427
EP - 1445
AD - BRESLAW, L.: Department of Medicine, U.S. Public Health Service, U.S. Penitentiary, Lewisburg, Pennsylvania, U.S.A.
N1 - Accession Number: 19600800995. Publication Type: Journal Article. Language: not specified. Registry Number: 7440-36-0, 28300-74-5, 15489-16-4, 921-53-9.
N2 - Breslaw gives a detailed report of two cases of Schistosoma mansoni infection from two Puerto Ricans in Lewisburg prison. Clinical symptoms were practically absent except for malnutrition and generalized epigastric pain with mild distention after meals. The most effective method of diagnosis was that of aspirating mucus from proctoscopic material. The treatment consisted of a complete course (90 c.c.) of fuadin for the first patient, which resulted in negative stool and proctoscopic examinations after two months. After that the patient was treated with antimony potassium tartrate; an 0.5% solution was slowly injected intravenously, with a total dose of 440 c.c. The second patient, who was also treated with tartar emetic, showed marked toxic side effects, bromsulphalein retention reaching 30% and eosinophilia 76%; but stool and proctoscopic examinations were negative after the therapy. Distribution of schistosomiasis in Puerto Rico is also discussed. N. Jones.
KW - adverse effects
KW - antimony
KW - antimony potassium tartrate
KW - clinical aspects
KW - correctional institutions
KW - emetics
KW - eosinophilia
KW - Hispanics
KW - infections
KW - malnutrition
KW - prisoners
KW - schistosomiasis
KW - snail-borne diseases
KW - stibophen
KW - symptoms
KW - trematode infections
KW - Puerto Rico
KW - man
KW - Schistosoma
KW - Schistosoma mansoni
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - Greater Antilles
KW - Caribbean
KW - America
KW - Developing Countries
KW - Latin America
KW - adverse reactions
KW - antimonials
KW - antimonyl potassium tartrate
KW - bilharzia
KW - bilharziasis
KW - clinical picture
KW - fluke infections
KW - Porto Rico
KW - potassium tartrate
KW - schistosomosis
KW - Strigeida
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - A bacteriological and parasitological survey of enteric infections in an Alaskan Eskimo area.
AU - FOURNELLE, H. J.
AU - WALLACE, I. L.
AU - RADER, V.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1958///
VL - 48
IS - 11, Pt. 1
SP - 1489
EP - 1497
SN - 0090-0036
AD - FOURNELLE, H. J.: Bacteriology Unit, Arctic Health Research Center of the Public Health Service, Anchorage, Alaska.
N1 - Accession Number: 19600800433. Publication Type: Journal Article. Language: not specified.
N2 - In Alaska where diarrhoea is a major health problem, a survey was made of its occurrence together with the occurrence of the causative bacterial pathogens and of intestinal parasites among the Eskimo population of ten villages and nine fishing camps. 33.7% of the population (average age 10 to 19 years) gave histories of diarrhoea. Protozoan parasites were more frequent than helminths. The only significant infection with the latter was Diphyllobothriutn sp. (prevalent in 10.2% in villages and 11.9% in fishing camps). The incidence of Enterobius vermicularis, Trichuris sp. and hookworm was low. In dogs, hookworms were the most frequent helminth parasites. There was no clear correlation between the occurrence of diarrhoea and that of parasites. G. I. Pozniak.
KW - animal parasitic nematodes
KW - diarrhoea
KW - helminths
KW - hookworms
KW - incidence
KW - infections
KW - nematode infections
KW - parasites
KW - protozoal infections
KW - villages
KW - Alaska
KW - USA
KW - Ancylostomatidae
KW - dogs
KW - Enterobius
KW - Enterobius vermicularis
KW - Protozoa
KW - Trichuris
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - small mammals
KW - Oxyuridae
KW - Enterobius
KW - Trichuridae
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Adenophorea
KW - diarrhea
KW - Enoplida
KW - intestinal parasites
KW - parasitic worms
KW - pinworm
KW - protozoal diseases
KW - scouring
KW - threadworm
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - The Siphonaptera of Utah. Their Taxonomy, Distribution, Host Relations, and Medical Importance.
AU - STARK, Harold E.
AU - B. A.
AU - M. S.
T2 - The Siphonaptera of Utah. Their Taxonomy, Distribution, Host Relations, and Medical Importance.
Y1 - 1958///
AD - STARK, Harold E.: Atlanta: U.S. Dept. of Health, Education & Welfare, Public Health Service, Bureau of State Services, Communicable Disease Center, Georgia.
N1 - Accession Number: 19602900058. Publication Type: Book. Language: not specified. Number of References: 126 figs. & 5 maps.
N2 - The first and only satisfactorily confirmed case of human plague in the State of Utah, U.S.A., was in a child bitten by a squirrel in 1936. Epizootics in native rodents were, at the time, being studied and this work, particularly since 1948, has been extended and intensified by various organizations. A brief outline of these developments is followed by. short accounts of the topography and climate of the State and some general problems in flea distribution related to these circumstances. A useful, illustrated, chapter describes methods for finding and catching fleas and their wild animal hosts; also mounting techniques. In a general consideration of the medical and economic aspects of fleas in Utah, emphasis is placed on plague. Brucella tularensis has also been isolated from a rodent flea in Utah; but not murine typhus. Several domestic species of flea are biting nuisances, and the usual veterinary aspects of fleas are noted. As regards plague, infection in wild animals or in their fleas has been proven on only 17 occasions in extensive, state-wide survey. All are from the central north-south mountains, usually over 6, 000 ft. Direct contact of man with native animals or their fleas is considered the means by which plague in man may occur again in Utah. But the possibility of its being derived through domestic rodents and their fleas is not wholly discounted. The author is not in favour of terms such as sylvatic, campestral, rural or urban plague, but seems not to have escaped entirely their generally descriptive convenience. There is a concise summation of recent writings on ways of assigning indices of vector efficiency to flea species. About 80% of the publication is on the systematics of fleas, with nearly 200 fine illustrations of parts of fleas supporting keys to 115 species. A list of species embodies a notation at once indicating whether a species has been proved naturally infected with plague or, experimentally, susceptible and capable of transmitting plague. Under each species in the general text there is synonymy, a record of type locality and host, and location of types. The medical interest is well summed for each species, where this is relevant. Wild animal plague findings are mapped, and 4 other maps show the known distribution in Utah of species of Thrassis, Opisocrostis, Diamanus montanus and Cediopsylla inaequalis. The last species appears free from implication in plague but involves subspeciation problems. The others are among about 40 species found naturally infected, and for not a few of which indices of vector efficiency have been derived experimentally. Hostflea associations are discussed briefly and summarized in a final chapter, in part by a table. References number nearly 300. D. S. Bertram.
KW - bites
KW - children
KW - disease vectors
KW - economics
KW - hosts
KW - human diseases
KW - infections
KW - murine typhus
KW - plague
KW - publications
KW - rural areas
KW - synonymy
KW - taxonomy
KW - techniques
KW - typhus fevers
KW - urban areas
KW - vector competence
KW - wild animals
KW - USA
KW - Utah
KW - Brucella
KW - man
KW - Oropsylla
KW - rodents
KW - Siphonaptera
KW - Brucellaceae
KW - Gracilicutes
KW - bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Pulicidae
KW - Siphonaptera
KW - Oropsylla
KW - Ceratophyllidae
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - Cediopsylla
KW - Diamanus
KW - Diamanus montanus
KW - epizootics
KW - flea-borne typhus
KW - Oropsylla montana
KW - systematics
KW - United States of America
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on the serology of echinococcosis.
AU - KAGAN, I. G.
AU - NORMAN, L.
AU - ALLAIN, D. S.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 4, Sect. 2
SP - 30
EP - 30
SN - 0022-3395
AD - KAGAN, I. G.: Communicable Disease Center, Public Health Service, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19600802268. Publication Type: Journal Article. Language: not specified.
N2 - The tannk acid haemagglutination and the bentonite flocculation tests were made with various Echinococcus granulosas and E. multilocularis antigens. Antisera were prepared in rabbits, and sera from infected patients were evaluated for specificity. Hydatid fluid of E. granulosus and cyst antigen of E. multilocularis were, fractionated with trichloracetic acid and the fractions tested for specificity. Hydatid fluid was the best antigen in both types of test and scoleces antigens the least specific, none of the antigens being species specific. Trichloracetic-sodium hydroxide soluble fractions of E. granulosus and E. multilocularis cyst antigen were more sensitive than the original antigens used. N. A. Hancock.
KW - antigens
KW - cestode infections
KW - haemagglutination
KW - human diseases
KW - hydatids
KW - immunoprecipitation tests
KW - infections
KW - serology
KW - Echinococcus
KW - Echinococcus multilocularis
KW - man
KW - rabbits
KW - Taeniidae
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Leporidae
KW - Lagomorpha
KW - small mammals
KW - antigenicity
KW - cyst fluid
KW - flocculation tests
KW - hemagglutination
KW - immunogens
KW - precipitin tests
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - Studies of 12 species of mosquitoes as potential vectors of filariae affecting skunks squirrels and raccoons in Maryland.
AU - EVANS, B. R.
AU - PHILLIPS, W. G.
AU - BICKLEY, W. E.
T2 - Bulletin. Maryland Agricultural Experiment Station
JO - Bulletin. Maryland Agricultural Experiment Station
JF - Bulletin. Maryland Agricultural Experiment Station
Y1 - 1959///
IS - A-99
SP - 31
EP - 31
AD - EVANS, B. R.: U.S. Public Health Service Quarantine Station, New Orleans (Algiers), Louisiana, U.S.A.
N1 - Accession Number: 19610801035. Publication Type: Miscellaneous. Language: not specified.
N2 - Four filariae, Dipetalonema procyonis Price from raccoons, a Dipetalonema sp. from squirrels, and two Dipetalonema spp. from skunks did not attain the infective stage in 12 intermediate host species including five Aedes spp., three Anopheles spp., two Culex spp., Mansonia perturbans and Psorophora ferox. The filariae were ingested by all hosts, but became sluggish and immobile in the mid-gut by the second day, and had disappeared by the third or fourth day. The immobile nematodes showed brown bands of varying widths, due either to nematode degeneration or encapsulation. First-stage larvae in the thoracic muscle of Anopheles punctipennis were sometimes covered by brown pigment similar, but not identical, to that of the bands produced in the gut. Probably A. punctipennis would not serve as a developmental host after a single blood meal, although filariae from the squirrel developed to the first larval stage. H. E. Welch.
KW - blood-meals
KW - encapsulation
KW - intermediate hosts
KW - intestines
KW - muscles
KW - vectors
KW - Maryland
KW - USA
KW - Aedes
KW - Anopheles
KW - Anopheles punctipennis
KW - Culex
KW - Culicidae
KW - Mansonia (Diptera)
KW - Nematoda
KW - Procyon lotor
KW - Psorophora
KW - Psorophora ferox
KW - Sciuridae
KW - squirrels
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Procyon
KW - Procyonidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - Psorophora
KW - rodents
KW - Sciuridae
KW - squirrels
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610801035&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The National Filaria Control Program (NFCP) of India: investigative challenges.
AU - BEYE, H. K.
AU - WRIGHT, W. H.
JO - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases
JF - Bulletin of the National Society of India for Malaria and other Mosquito-Borne Diseases
Y1 - 1959///
VL - 7
IS - 2
SP - 45
EP - 52
AD - BEYE, H. K.: U.S. Department of Health, Education & Welfare, Public Health Service, National Institutes of Health, Bethesda 14, Maryland, U.S.A.
N1 - Accession Number: 19610801377. Publication Type: Journal Article. Language: not specified.
N2 - Beye & Wright outline a variety of research projects that might be undertaken by the National Filaria Control Programme of India in its efforts to control, and ultimately eradicate, infections due to Wuchereria bancrofti and W. malayi. J. W. Smith.
KW - control programmes
KW - infections
KW - India
KW - Brugia malayi
KW - Onchocercidae
KW - Wuchereria
KW - Wuchereria bancrofti
KW - Brugia
KW - Onchocercidae
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Wuchereria
KW - South Asia
KW - Asia
KW - Developing Countries
KW - Commonwealth of Nations
KW - control programs
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - [English title not available] / Influencia del tamaño, motilidad, ayuno y edad sobre la actividad metabólica.
AU - VON BRAND, T.
T2 - Biologica
JO - Biologica
JF - Biologica
Y1 - 1959///
IS - 27-28
SP - 117
EP - 128
PB - Santiago
AD - VON BRAND, T.: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Allergy & Infectious Diseases, Bethesda, Maryland, U.S.A.
N1 - Accession Number: 19610801175. Publication Type: Miscellaneous. Language: not specified.
N2 - It is impossible to indicate, in a brief abstract, the whole content of this paper. The original must be read. After a short introduction von Brand quotes Rubner's conclusion that the metabolic rates of animals varying in size are constant in relation to a unit of surface area and discusses the difficulty of defining this term and the possible avoidance of this difficulty by relating the metabolic rate to the body-weight. In some cold-blooded animals (newts, some molluscs) the law of surface area, expressed in relation to two-thirds of the body-weight, seems adequate to express the relation between size and the metabolic index; but in others (insects, Helix) metabolism increases in proportion to increase in size and in others an intermediate relation exists. Allometric plotting of the weight per individual and the oxygen consumption is then discussed and illustrated by graphs of data obtained from large and small free-living and parasitic nematodes. Von Brand then discusses work on respiratory enzymes and mitochondria and on the influence of muscular work, e.g. the study of insects in flight and at rest, of crawling and swimming in nematodes and of floating by planktonic organisms. Finally the influence of age is discussed. For the study of this von Brand thinks that the nematodes, many of which have a long larval and a short adult life, are admirably suited. G. Lapage.
KW - law
KW - legislation
KW - muscles
KW - oxygen consumption
KW - plankton
KW - Mollusca
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - legal aspects
KW - legal principles
KW - Laws and Regulations (DD500)
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Development in vitro of some parasitic nematodes of vertebrates.
AU - WEINSTEIN, P. P.
AU - JONES, M. F.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1959///
VL - 77
IS - 2
SP - 137
EP - 162
SN - 0077-8923
AD - WEINSTEIN, P. P.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A.
N1 - Accession Number: 19610800260. Publication Type: Journal Article. Language: not specified.
N2 - Weinstein & Jones describe some recent investigations on the growth and maintenance of nematode larvae in vitro. A basal medium of serum-chick embryo homogenate was used. In relatively high concentrations of these materials filariform larvae of Nippostrongylus muris were capable of reaching the fifth stage. Human serum was compared directly with rat serum and found to be superior. However, considerable variations in the yield of fifth-stage worms occurred with different samples of the same basal medium. Supplements such as a vitamin mixture, Eagles' medium and liver concentrate increased the fifth-stage worm yield. The worms did not mate in culture but infertile eggs were deposited by the females. In chemically defined media alone, or with supplements added, survival but no growth occurred. Under strict axenic conditions, development from egg to mature adult was obtained without the use of antibiotics. Worms which were removed from the intestine of the rat did not mate during in vitro culture. Third-stage larvae of Necator americanus showed some development when cultured by similar techniques. J. E. D. Keeling.
KW - antibiotics
KW - blood serum
KW - culture media
KW - embryos
KW - in vitro
KW - in vitro culture
KW - larvae
KW - liver
KW - nematode larvae
KW - supplements
KW - survival
KW - techniques
KW - Ancylostomatidae
KW - man
KW - Necator
KW - Necator americanus
KW - Nematoda
KW - Nippostrongylus
KW - rats
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ancylostomatidae
KW - Necator
KW - Heligmonellidae
KW - Muridae
KW - rodents
KW - small mammals
KW - chemically defined media
KW - Secernentea
KW - Strongylida
KW - third stage larvae
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - A comparison of the development of some rat and mouse helminths in germfree and conventional guinea pigs.
AU - NEWTON, W. L.
AU - WEINSTEIN, P. P.
AU - JONES, M. F.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1959///
VL - 78
IS - 1
SP - 290
EP - 306
SN - 0077-8923
AD - NEWTON, W. L.: Laboratory of Tropical Diseases, National Institute of Allergy and Infectious Diseases, Public Health Service, Bethesda, Maryland, U.S.A.
N1 - Accession Number: 19610800093. Publication Type: Journal Article. Language: not specified.
N2 - guineapigs which had been delivered and maintained germ-free were compared with conventional guineapigs as hosts for a number of helminths normally parasitic in rats and mice. In conventional animals Nippostrongylus muris failed to develop but fourth-stage larvae and adults were recovered from two of six germ-free guineapigs which received similar infections. Germ-free animals proved more satisfactory hosts for Nematospiroides dubius than did conventional animals. It was demonstrated that the method of delivery and type of diet were not the underlying reason for this difference. Both species produced fertile eggs in germ-free animals. Hymenolepis nana developed successfully in both types of host. J. E. D. Keeling.
KW - helminths
KW - infections
KW - methodology
KW - small mammals
KW - techniques
KW - guineapigs
KW - Heligmosomoides
KW - Heligmosomoides polygyrus
KW - Hymenolepididae
KW - Hymenolepis
KW - mice
KW - Nippostrongylus
KW - rats
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Heligmosomidae
KW - Nematoda
KW - invertebrates
KW - Heligmosomoides
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - Hymenolepididae
KW - Muridae
KW - small mammals
KW - Heligmonellidae
KW - Cyclophyllidea
KW - guinea pigs
KW - methods
KW - parasitic worms
KW - Secernentea
KW - Strongylida
KW - Vampirolepis
KW - Vampirolepis nana
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The effects of low temperatures on larval cestodes and other helminths in fish.
AU - HILLIARD, D. K.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 3
SP - 291
EP - 294
SN - 0022-3395
AD - HILLIARD, D. K.: Arctic Health Research Center, Public Health Service, U.S. Department of Health, Education, and Welfare, Anchorage, Alaska.
N1 - Accession Number: 19600800928. Publication Type: Journal Article. Language: not specified.
N2 - Hilliard subjected specimens of fresh-water fishes containing helminth parasites to temperatures of-6°C, -12°C. and -18°C. Following exposures of 24, 48 or 72 hours, the fishes were immersed in warm water (30°C.) until sufficiently pliable for the viscera to be removed. Plerocercoid larvae and nematodes (Porrocaecum sp. and a spirurid) were removed from their cysts and placed in 0.4% physiological saline. Non-viability of the organism was established if no movements occurred following a owing a five minute exposure to the saline solution. It was found that larvae of different species of the genus Diphyllobotkrium differed in their range of tolerance to cold. The most resistant plerocercoid larvae on a host-weight basis, were those of D. osmeri which tolerated freezing temperatures for 48 hours at -6°C. and for 24 hours at -12°C. in a host averaging 52 gm. No viable helminths were recovered after exposure for two days to a temperature of-18°C. I. L. Owen.
KW - cold
KW - freshwater fishes
KW - helminths
KW - larvae
KW - parasites
KW - saline water
KW - temperature
KW - tolerance
KW - Anisakidae
KW - Cestoda
KW - fishes
KW - Nematoda
KW - Porrocaecum
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Platyhelminthes
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Ascarididae
KW - Ascaridida
KW - cysts
KW - parasitic worms
KW - salt water
KW - Secernentea
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on chemotherapy of experimental schistosomiasis. V. Enhancement of the schistosomacidal activity of tartar emetic and stibophen by glycerin.
AU - LUTTERMOSER, G. W.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 3
SP - 301
EP - 309
SN - 0022-3395
AD - LUTTERMOSER, G. W.: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A.
N1 - Accession Number: 19610802748. Publication Type: Journal Article. Language: not specified. Registry Number: 15489-16-4, 28300-74-5.
N2 - Luttermoser has attempted to increase the schistosomicidal activity of tartar emetic and stibophen by the addition of one of several possible organic adjuvants; only glycerin, of 32 compounds tested, was successful. 50 mg. or 75 mg. of tartar emetic per kg. body-weight given orally twice a day for five days or 160 mg. of stibophen per kg. given intraperitoneally six times in five days reduced Schistosoma mansoni infection in mice by about 50%. The same regimen of tartar emetic given in a 50% aqueous solution of glycerin reduced the infection by about 74%; the same regimen of stibophen given in a 25% aqueous solution of glycerin reduced the infection by about 79%. Glycerin given alone either orally or parenterally did not kill any schistosomes. Multiple injections of 25% glycerin solutions of tartar emetic or stibophen into the tail vein of mice usually resulted in haematoma and leakage of the drug into the tissues. The acute toxicity of both tartar emetic and stibophen for uninfected mice was similar irrespective of whether the drugs were given in aqueous or in glycerin solution or as single or multiple doses; similar results were obtained with uninfected dogs. Luttermoser discusses the possible ways in which glycerin might enhance the activity of these drugs; the stability of tartar emetic in vitro was increased by the addition of glycerin, which suggests that in vivo this adjuvant could maintain the level of the drug in the blood for a longer period of time so enhancing its activity. J. W. Smith.
KW - adjuvants
KW - drug therapy
KW - emetics
KW - in vitro
KW - infections
KW - regimens
KW - schistosomiasis
KW - snail-borne diseases
KW - stibophen
KW - toxicity
KW - toxicology
KW - trematode infections
KW - dogs
KW - mice
KW - Schistosoma
KW - Schistosoma mansoni
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - antimonials
KW - antimonyl potassium tartrate
KW - bilharzia
KW - bilharziasis
KW - chemotherapy
KW - fluke infections
KW - in vivo
KW - schistosomosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on the helminth fauna of Alaska. XXXIV. The parasites of wolves, Canis lupus L.
AU - RAUSCH, R.
AU - WILLIAMSON, F. S. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 4
SP - 395
EP - 403
SN - 0022-3395
AD - RAUSCH, R.: Zoonotic Disease Section, Arctic Health Research Center, Public Health Service, U.S. Department of Health, Education and Welfare, Anchorage, Alaska.
N1 - Accession Number: 19600800363. Publication Type: Journal Article. Language: not specified.
N2 - During a ten-year survey, 200 wolves were killed, principally in the Brooks Range region of arctic Alaska, and the following helminths were found: Taenia hydatigena, T. krabbei, T. multiceps, Echinococcus granulosus, Alaria canis, Toxascaris leonina, Uncinaria stenocephala and Trichinella spiralis. Short notes are given on the rates of infection, distribution and life-histories of these helminths. Although E. granulosus and T. spiralis are species pathogenic to man, wolves as reservoirs of human infections are thought to be unimportant when the dose association between hunters and traders and their dogs is taken into consideration. G. I. Pozniak.
KW - fauna
KW - helminths
KW - human diseases
KW - infections
KW - life history
KW - parasites
KW - Alaska
KW - USA
KW - Ascarididae
KW - dogs
KW - Echinococcus
KW - Echinococcus granulosus
KW - man
KW - Nematoda
KW - Taenia
KW - Taenia hydatigena
KW - Taeniidae
KW - Toxascaris
KW - Toxascaris leonina
KW - Trichinella
KW - Trichinella spiralis
KW - Uncinaria
KW - Uncinaria stenocephala
KW - wolves
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - small mammals
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - Taenia
KW - Ascarididae
KW - Toxascaris
KW - Trichinellidae
KW - Trichinella
KW - Ancylostomatidae
KW - Uncinaria
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Adenophorea
KW - Ascaridida
KW - Canis lupus
KW - Enoplida
KW - parasitic worms
KW - Secernentea
KW - Strongylida
KW - United States of America
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - An intestinal parasite survey on Rongelap Atoll in the Marshall Islands.
AU - GOLDMAN, M.
AU - CARVER, R. K.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1959///
VL - 8
IS - 4
SP - 417
EP - 423
SN - 0002-9637
AD - GOLDMAN, M.: Department of Health, Education, and Welfare, Public Health Service, Communicable Disease Center, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19600800434. Publication Type: Journal Article. Language: not specified.
N2 - No significant difference was found between parasitic infections of a group of 69 Marshall islanders exposed to radio-active fall-out four years previously and a group of 112 unexposed islanders now living in the same atoll. The over-all rates of helininth infections, determined by single stool examinations, were Trichuris trichiura 34.3% and hookworm 5.5%, the worm burdens being generally low. Ascaris was absent. The infections were studied in relation to the age and sex of the islanders. G. I. Pozniak.
KW - animal parasitic nematodes
KW - helminths
KW - hookworms
KW - infections
KW - islands
KW - nematode infections
KW - parasitoses
KW - Marshall Islands
KW - Ancylostomatidae
KW - Ascaris
KW - man
KW - Trichuris
KW - Trichuris trichiura
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascarididae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Trichuridae
KW - Trichuris
KW - Trust Territory of the Pacific Islands
KW - Micronesia
KW - Oceania
KW - Pacific Islands
KW - American Oceania
KW - Developing Countries
KW - islands
KW - Adenophorea
KW - Ascaridida
KW - Enoplida
KW - intestinal parasites
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Hepato-splenic schistosomiasis in mice.
AU - DEWITT, W. B.
AU - WARREN, K. S.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1959///
VL - 8
IS - 4
SP - 440
EP - 446
SN - 0002-9637
AD - DEWITT, W. B.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A.
N1 - Accession Number: 19600800950. Publication Type: Journal Article. Language: not specified.
N2 - Mice infected with approximately 125 cercariae of Schistosoma mansoni harboured an average burden of 24 worms per animal. In the liver maximum egg density was reached at eight weeks after infection (1, 765 per gm.). At ten weeks the mice showed symptoms which are normally associated with the syndrome designated hepato-splenic schistosomiasis, namely, liver enlargement with granulomatous lesions or scar tissue around deposited eggs, splenomegaly, oesophageal varices and ascites. Some mice also developed a severe anaemia. Histológical examination revealed little damage to liver parenchyma. Liver function test results could be attributed to abnormal conditions produced by portal hypertension. These observations suggested that the pathogenesis of the syndrome was directly related to mechanical obstruction of the portal blood flow produced by tissue reaction associated with schistosome eggs. J. E. D. Keeling.
KW - anaemia
KW - ascites
KW - cercariae
KW - granuloma
KW - hepatomegaly
KW - hypertension
KW - infections
KW - liver
KW - liver cells
KW - liver function
KW - oesophagus
KW - parenchyma
KW - pathogenesis
KW - portal hypertension
KW - schistosomiasis
KW - snail-borne diseases
KW - spleen
KW - splenomegaly
KW - symptoms
KW - trematode infections
KW - mice
KW - Schistosoma
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - anemia
KW - bilharzia
KW - bilharziasis
KW - esophagus
KW - fluke infections
KW - hepatocytes
KW - high blood pressure
KW - liver enlargement
KW - schistosomosis
KW - Strigeida
KW - syndromes
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on the helminth fauna of Alaska. XXXVI. Parasites of the wolverine, Guio guio L., with observations on the biology of Taenia ttoitchelli Schwartz, 1924.
AU - RAUSCH, R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 5
SP - 465
EP - 484
SN - 0022-3395
AD - RAUSCH, R.: Arctic Health Research Center, Public Health Service, U.S. Department of Health, Education and Welfare, Anchorage, Alaska.
N1 - Accession Number: 19600801440. Publication Type: Journal Article. Language: not specified.
N2 - Rausch records six species of helminth from 69 of 80 wolverines examined from four localities in Alaska: (i) Cestoda-Mesocestoides kirbyi and Taenia twtchelli; (ii) Nematoda-Trichinella spiralis, Molineus patens, Ascaris devosi and Physaloptera torquata. One specimen of an apparently undescribed species of Alaria was recovered from a captive wolverine. M. kirbyi, A. devosi, P. torquata and Alaria sp. are recorded for the first time from the wolverine, and M. patens for the first time from this host in North America. Experimental feedings of the eggs of T. tintchelli to six rodent species produced multiscolex larvae. In five other rodent species and the Rhesus monkey, larval development was abnormal or severely inhibited. The development of, and host reactions to, larvae of T. ttoitchelli are described in detail. In the intermediate host, oncospheres enter the portal circulation, pass through die liver, and localize in the Jungs. After several weeks, the majority of the larvae emigrate to the pleural cavities and become vesicular multiscolex forms. In one naturally infected porcupine, only uniscolex larvae were found, which when fed to a wolverine produced ovigerous adults 66 days later. The original description of T. iwitchelli is supplemented. Characteristics of the rostellar hooks serve to distinguish the adult T. twitchelli from both T. mustelae Gmelin, 1790 and T. mortis (Zeder, 1803), the only other species of Taenia known from boreal mustelids. E. I. Sillman.
KW - biology
KW - developmental stages
KW - fauna
KW - helminths
KW - intermediate hosts
KW - larvae
KW - liver
KW - oncospheres
KW - parasites
KW - pleura
KW - Alaska
KW - America
KW - North America
KW - USA
KW - Ascaris
KW - Gulo gulo
KW - Macaca mulatta
KW - Mesocestoides
KW - Mesocestoididae
KW - Molineus
KW - monkeys
KW - Nematoda
KW - Physaloptera
KW - Physalopteridae
KW - rodents
KW - Taenia
KW - Taeniidae
KW - Trichinella
KW - Trichinella spiralis
KW - Ascarididae
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Gulo
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - small mammals
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - Mesocestoididae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - Molineidae
KW - Physalopteridae
KW - Taeniidae
KW - Trichinellidae
KW - Trichinella
KW - Molineus
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Adenophorea
KW - Ascaridida
KW - Enoplida
KW - growth phase
KW - hooks
KW - Molineus patens
KW - parasitic worms
KW - porcupines
KW - Secernentea
KW - Spirurida
KW - Strongylida
KW - United States of America
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The use of metabolic antigens in the flocculation tests for the serologic diagnosis of trichinosis.
AU - NORMAN, L.
AU - SADUN, E. H.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 5
SP - 485
EP - 489
SN - 0022-3395
AD - NORMAN, L.: Communicable Disease Center, Public Health Service, U.S. Department of Health, Education and Welfare, Adanta, Georgia.
N1 - Accession Number: 19600801547. Publication Type: Journal Article. Language: not specified.
N2 - Norman & Sadun compare metabolic and somatic antigens of larvae of Trichinella spiralis by means of flocculation tests with sera from a variety of animals. The metabolic antigen was more sensitive when tested with sera from men with proven or highly suggestive trichinosis. With sera from experimentally infected pigs the antigens showed equal sensitivity. Both antigens were tested with sera from 163 wild animals which were infected with helminths other than T. spiralis; 156 gave negative reactions. Experiments in which the absorption of rabbit serum antibodies by metabolic and somatic antigens were attempted suggested that specific reacting substances were present in the two antigens. W. P. Rogers.
KW - antibodies
KW - antigens
KW - blood serum
KW - diagnosis
KW - experimental infection
KW - helminthoses
KW - helminths
KW - immunoprecipitation tests
KW - infections
KW - larvae
KW - nematode infections
KW - serology
KW - somatic antigens
KW - trichinosis
KW - wild animals
KW - Nematoda
KW - pigs
KW - Trichinella
KW - Trichinella spiralis
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - ungulates
KW - Trichinellidae
KW - Nematoda
KW - Trichinella
KW - Adenophorea
KW - antigenicity
KW - Enoplida
KW - experimental transmission
KW - flocculation tests
KW - hogs
KW - immunogens
KW - parasitic worms
KW - precipitin tests
KW - swine
KW - trichinellosis
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Significance of human intestinal helminths in eastern Kentucky.
AU - ATCHLEY, F. O.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 5
SP - 518
EP - 518
SN - 0022-3395
AD - ATCHLEY, F. O.: Communicable Disease Center, U.S. Department of Health, Education and Welfare, Bureau of State Services, Public Health Service, Phoenix, Arizona, U.S.A.
N1 - Accession Number: 19600800430. Publication Type: Journal Article. Language: not specified.
N2 - Single stool examinations of 1, 244 patients at admission to a hospital in Kentucky showed 32% to be infected with helminths. These were Ascaris Itimbricoides (12%), Trichuris trichiwra (14%), Strongylaides stercoralis (5%) and hookworm (1%). In 7% of the patients helminthiases were included in the final hospital diagnosis. G. I. Pozniak.
KW - animal parasitic nematodes
KW - helminthoses
KW - helminths
KW - hookworms
KW - infections
KW - nematode infections
KW - Kentucky
KW - USA
KW - Ancylostomatidae
KW - Ascaris
KW - man
KW - Strongyloides stercoralis
KW - Trichuris
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascarididae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Strongyloides
KW - Strongyloididae
KW - Trichuridae
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - East South Central States of USA
KW - Adenophorea
KW - Ascaridida
KW - Enoplida
KW - intestinal parasites
KW - parasitic worms
KW - Rhabditida
KW - Secernentea
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Quantitative recovery of helminth eggs from relatively large samples of faeces and sewage.
AU - ROWAN, W. B.
AU - GRAM, A. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1959///
VL - 45
IS - 6
SP - 615
EP - 621
SN - 0022-3395
AD - ROWAN, W. B.: Communicable Diseases Center, Bureau of State Services, Public Health Service, U.S. Department of Health, Education and Welfare, San Juan, Puerto Rico.
N1 - Accession Number: 19610800250. Publication Type: Journal Article. Language: not specified.
N2 - Sediment from a large volume of sewage is strained, blended and dispensed from a reservoir on to a separating tray through a number of fine glass jets. The flow of sewage must be slow and of regular speed to ensure good results. As the sewage flows over 1.0% saline in channels running longitudinally along the separating tray, helminth eggs and heavier particles settle and collect in the saline. This is collected and the eggs are re-sedimented over 2.0% saline. Aliquots of the final suspension are vacuum filtered in a Büchner funnel. The filter paper can be treated with ninhydrin reagent to stain Schistosoma mansoni eggs, but Ascaris and Trichuris eggs show up well without staining. The filter paper is sandwiched with a few ml. of 2% agar-agar between two glass plates for examination under a low power dissecting microscope. Experimental results show that the efficiency in recovering eggs from sewage is 70%, 40% and 60% for Ascaris, Trichuris and Schistosoma respectively. The technique can also be used to recover eggs from animal tissues or to estimate the total number of eggs passed by a subject under treatment or experimentation. J. E. D. Keeling.
KW - animal tissues
KW - faeces
KW - helminth ova
KW - helminths
KW - sewage
KW - staining
KW - wastes
KW - Ascarididae
KW - Ascaris
KW - Nematoda
KW - Schistosoma
KW - Schistosoma mansoni
KW - Trichuridae
KW - Trichuris
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascarididae
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - Schistosoma
KW - Trichuridae
KW - Adenophorea
KW - Ascaridida
KW - Enoplida
KW - feces
KW - parasitic worms
KW - Secernentea
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Wastes and Refuse (XX300)
KW - Wastes (General) (XX000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Investigation of parasitic infections "in the central area of Philadelphia.
AU - WEINER, D.
AU - BROOKE, M. M.
AU - WITKOW, A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1959///
VL - 8
IS - 6
SP - 625
EP - 629
SN - 0002-9637
AD - WEINER, D.: Communicable Disease Center, Public Health Service, Department of Health, Education and Welfare, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19600801590. Publication Type: Journal Article. Language: not specified.
N2 - An intestinal parasite survey of schoolchildren (167 Puerto Rican, 49 Negro and 169 white) was conducted in 1957 in Philadelphia in order to estimate the parasitological situation arising from an increase in Puerto Rican residents. The helminth prevalence rates (no specific counts were made for Enterobius vermicularis) were considerably higher in the Puerto Rican children. The most frequent helminths were Trichuris trichiura and hookworms which infected 67.7% and 21% of Puerto Ricans. The other species identified were Ascaris lumbricoides, Schistosoma mansoni, Hymenolepis nana) Strongylöides stercoralis and E. vermicularis. A significant reduction in infection was observed in children after six years residence in the U.S.A. The infections were studied in relation to quality of housing. G. I. Pozniak.
KW - animal parasitic nematodes
KW - blacks
KW - children
KW - helminths
KW - Hispanics
KW - hookworms
KW - infections
KW - parasitoses
KW - school children
KW - Pennsylvania
KW - USA
KW - Ancylostomatidae
KW - Ascaris
KW - Ascaris lumbricoides
KW - Enterobius
KW - Enterobius vermicularis
KW - Hymenolepididae
KW - Hymenolepis
KW - man
KW - Schistosoma
KW - Schistosoma mansoni
KW - Strongyloides stercoralis
KW - Trichuris
KW - Trichuris trichiura
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascarididae
KW - Ascaris
KW - Oxyuridae
KW - Enterobius
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - Hymenolepididae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Schistosoma
KW - Strongyloides
KW - Strongyloididae
KW - Trichuridae
KW - Trichuris
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Adenophorea
KW - Ascaridida
KW - Cyclophyllidea
KW - Enoplida
KW - intestinal parasites
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - pinworm
KW - Rhabditida
KW - school kids
KW - schoolchildren
KW - Secernentea
KW - Strigeida
KW - threadworm
KW - United States of America
KW - Vampirolepis
KW - Vampirolepis nana
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Relation of water velocity to Schistosoma mansoni infection in mice.
AU - ROWAN, W. B.
AU - GRAM, A. L.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1959///
VL - 8
IS - 6
SP - 630
EP - 634
SN - 0002-9637
AD - ROWAN, W. B.: Communicable Disease Center, Bureau of State Services, Public Health Service, U.S. Department of Health, Education and Welfare, Sau Juan, Puerto Rico.
N1 - Accession Number: 19600801511. Publication Type: Journal Article. Language: not specified.
N2 - Rowan & Gram exposed mice to Schistosoma mansoni cercariae in water travelling at different velocities in an attempt to estimate the safety of using fast moving water known to contain schistosome cercariae, for bathing, clothes washing or other purposes. Mice were exposed in a specially constructed apparatus in the laboratory, and in a stream known to contain S. mansoni cercariae. The velocity of the water in the experiments ranged from 2-7 ml. per second to 50 ml. per second. Samples of water taken at intervals for estimation of cercarial density, revealed a concentration of from 0.35 to 95.4 cercariae per litre. Rowan & Gram found that if the density of the cercariae in the water was constant, mice exposed in fast running water had heavier infections than those in slow water. In addition, the percentage recovery of approaching cercariae as adult worms in mice increased with an increase in the water velocity. D. L. H. Robinson.
KW - cercariae
KW - clothing
KW - infections
KW - safety
KW - mice
KW - Schistosoma
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - apparel
KW - clothes
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Recent advances in carbohydrate biochemistry of helminths.
AU - Brand, T. von
JO - Helminthological Abstracts
JF - Helminthological Abstracts
Y1 - 1960///
VL - 29
IS - 2
SP - 97
EP - 111
CY - Wallingford; UK
PB - CABI Publishing
AD - Brand, T. von: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, USA.
N1 - Accession Number: 20063028328. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Helminthology; Veterinary Science
KW - biochemistry
KW - biosynthesis
KW - carbohydrate metabolism
KW - carbohydrates
KW - helminths
KW - polysaccharides
KW - reviews
KW - complex carbohydrates
KW - parasitic worms
KW - saccharides
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A three-year epidemiologic study of intestinal parasites in a selected group of mental patients.
AU - JEFFERY, G. M.
JO - American Journal of Hygiene
JF - American Journal of Hygiene
Y1 - 1960///
VL - 71
IS - 1
SP - 1
EP - 8
AD - JEFFERY, G. M.: Department of Health, Education and Welfare, Public Health Service, National Institute of Allergy and Infectious Diseases, Laboratory of Parasite Chemotherapy, P.O. Box 717, Columbia, South Carolina, U.S.A.
N1 - Accession Number: 19600800985. Publication Type: Journal Article. Language: not specified.
N2 - Incidence of parasites was studied over a three-year period in mental patients, 110 for the total duration with nine examinations, and 199 for varying duration with one to eight examinations. The incidence and persistence of hookworms, Strongyloides stercoralis and Trichuris trichiura are tabulated and discussed. During the early stages of the survey the patients were housed in an old dilapidated hospital; they were then transferred to a new modern building and the implication of improved sanitation studied. Transmission of hookworm ceased and that of S. stercoralis and T. trichiura was greatly reduced. Hookworm and T. trichiura persisted for the three-year period in most cases. [No mention is made of treatment.] N. A. Hancock.
KW - animal parasitic nematodes
KW - developmental stages
KW - helminths
KW - hookworms
KW - human diseases
KW - incidence
KW - mental retardation
KW - nematode infections
KW - parasites
KW - sanitation
KW - Ancylostomatidae
KW - man
KW - Strongyloides
KW - Strongyloides stercoralis
KW - Trichuris
KW - Trichuris trichiura
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Strongyloididae
KW - Strongyloides
KW - Trichuridae
KW - Trichuris
KW - Adenophorea
KW - Enoplida
KW - growth phase
KW - intestinal parasites
KW - mental deficiency
KW - mentally handicapped
KW - parasitic worms
KW - Rhabditida
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Larva migrans.
AU - WEINER, D.
JO - Veterinary Medicine
JF - Veterinary Medicine
Y1 - 1960///
VL - 55
IS - 8
SP - 38
EP - 50
SN - 8750-7943
AD - WEINER, D.: U.S. Public Health Service, Division of Special Health Services, Washington 25, D.C., U.S.A.
N1 - Accession Number: 19610800035. Publication Type: Journal Article. Language: not specified.
N2 - Weiner reviews current knowledge on cutaneous and visceral larva migrans, its causative agents and the diagnosis and distribution. G. I. Pozniak.
KW - larva migrans
KW - visceral larva migrans
KW - creeping eruption
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Survival, and protection against chlorination, of human enteric pathogens in free-living nematodes isolated from water supplies.
AU - CHANG, S. L.
AU - BERG, G.
AU - CLARKE, N. A.
AU - KABLER, P. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1960///
VL - 9
IS - 2
SP - 136
EP - 142
SN - 0002-9637
AD - CHANG, S. L.: Robert A. Taft Sanitary Engineering Center, Bureau of State Services, Public Health Service, U.S. Department of Health, Education and Welfare, Cincinnati, Ohio, U.S.A.
N1 - Accession Number: 19600801703. Publication Type: Journal Article. Language: not specified. Registry Number: 7782-50-5.
N2 - Free-living nematodes Diplogaster nudicapitattis and Cheilobus quadrilabiatus, found in a city water supply, were fed with Salmonella typhosa, S. paratyphi, S. typhimurium, Shigella sonnei and Sh. dysenteriae II. In addition a suspension containing both adults and larvae of the two worms was fed Coxsackie A9 and the HEV strain of ECHO 7 enteric viruses, the suspension being exposed to varying concentrations of chlorine for varying periods. The worms were not killed at concentrations of 2.5 to 3.0 p.p.m. chlorine but with high chlorine and longer contact time mortality rose. The pathogens survived in the gut for some time after the carrier worms had been killed and resistance to chlorine in descending order was: sheathed larvae, adults, non-sheathed larvae. The authors suggest that nematodes of the family Rhabditidae and of sewage treatment origin may be potential carriers of pathogens. W. K. Dunscombe.
KW - carrier state
KW - chlorination
KW - chlorine
KW - free living nematodes
KW - human diseases
KW - intestines
KW - larvae
KW - mortality
KW - sewage
KW - survival
KW - wastes
KW - water supply
KW - man
KW - Nematoda
KW - Salmonella
KW - Salmonella typhimurium
KW - Shigella
KW - Shigella sonnei
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Enterobacteriaceae
KW - Gracilicutes
KW - bacteria
KW - prokaryotes
KW - Salmonella
KW - Shigella
KW - Nematoda
KW - death rate
KW - Diplogaster
KW - Diplogasterida
KW - Diplogasteridae
KW - Secernentea
KW - water supplies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
KW - Human Wastes and Refuse (XX300)
KW - Wastes (General) (XX000)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Human sparganosis in Alabam.
AU - GLEASON, N. N.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1960///
VL - 46
IS - 2
SP - 230
EP - 230
SN - 0022-3395
AD - GLEASON, N. N.: United States Public Health Service, Communicable Diseases Center, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19610800594. Publication Type: Journal Article. Language: not specified.
N2 - Gleason reports on an unidentified case of sparganosis in a woman in Alabama. The pseudophyllidean larva which was recovered on lancing of a nodule near the right breast, measured 94 mm. by 4 mm. and had a club-shaped anterior end with a shallow groove and a thin irregular posterior end. G. I. Pozniak.
KW - cestode infections
KW - infections
KW - sparganosis
KW - women
KW - Alabama
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - East South Central States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on echinococcosis: serology of crude and fractionated antigens prepared from Echinococcus granulosus and Echinococcus multilocularis.
AU - KAGAN, I. G.
AU - NORMAN, L.
AU - ALLAIN, D. S.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1960///
VL - 9
IS - 3
SP - 248
EP - 261
SN - 0002-9637
AD - KAGAN, I. G.: Department of Health, Education and Welfare, Public Health Service, Communicable Disease Center, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19610802026. Publication Type: Journal Article. Language: not specified.
N2 - Using fluid from hydatid cysts of Echinococcus granulosus from pigs in Tennessee and cysts of E. multilocularis from experimentally infected cotton-rats, Kagan et al. prepared fractions after the techniques employed by Dennis. These fractions were used as test antigens for tannic acid haemagglutination and for bentonite flocculation tests on sera from patients infected with E. granulosus and from Eskimos believed to be infected with E. multilocularis; in addition, antisera from rabbits previously inoculated with antigenic material from both species of Echinococcus was tested. Absolute specificity was not observed in either test with hydatid fluid, scoleces, cyst and membrane antigens. Hydatid fluid with both tests, gave the best results from known human E. granulosus infections, and was as reactive as the fractions. Crude hydatid fluid was less satisfactory with the suspected cases of E. multilocularis infections, fractionated antigens from the whole cyst being superior. G. A. Webster.
KW - antigens
KW - cestode infections
KW - experimental infection
KW - haemagglutination
KW - hydatids
KW - immunoprecipitation tests
KW - infections
KW - Inuit
KW - serology
KW - tannins
KW - techniques
KW - Tennessee
KW - USA
KW - Echinococcus
KW - Echinococcus granulosus
KW - Echinococcus multilocularis
KW - Eucestoda
KW - man
KW - pigs
KW - rabbits
KW - Taeniidae
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - ungulates
KW - Leporidae
KW - Lagomorpha
KW - small mammals
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - East South Central States of USA
KW - antigenicity
KW - cyst fluid
KW - cysts
KW - Eskimos
KW - experimental transmission
KW - flocculation tests
KW - hemagglutination
KW - hogs
KW - immunogens
KW - precipitin tests
KW - swine
KW - tannic acid
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Out-patient tolerance and anthelmintic activity of new formulations of dithiazanine.
AU - FEBLES, Jr.
AU - F.
AU - BROOKE, M. M.
AU - JANOWSKY, C. C.
AU - PERRI, A. M.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1960///
VL - 9
IS - 4
SP - 415
EP - 418
SN - 0002-9637
AD - FEBLES, Jr.: Communicable Disease Center, Public Health Service, Department of Health, Education & Welfare, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19610802048. Publication Type: Journal Article. Language: not specified. Registry Number: 514-73-8.
N2 - Three new formulations of dithiazanine with longer disintegration times than those of the present commercial product were significantly better tolerated in a test of 426 hospital outpatients infected with Trichuris trichiura. A formulation containing methyl cellulose (taking 60 to 90 minutes to disintegrate) was tolerated almost as well as a placebo. The new formulations were as effective against T. trichiura as the commercial product. Insufficient infections with Ascaris lumbricoides, hookworm and Strongyloides stercoralis were included in the study to determine the effectiveness of the new formulations against these infections. J. W. Smith.
KW - animal parasitic nematodes
KW - anthelmintics
KW - dithiazanine iodide
KW - effects
KW - helminths
KW - hookworms
KW - infections
KW - nematode infections
KW - placebos
KW - tolerance
KW - Ancylostomatidae
KW - Ascarididae
KW - Ascaris
KW - Ascaris lumbricoides
KW - Nematoda
KW - Strongyloides
KW - Strongyloides stercoralis
KW - Strongyloididae
KW - Trichuridae
KW - Trichuris
KW - Trichuris trichiura
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascarididae
KW - Ascaris
KW - Strongyloididae
KW - Strongyloides
KW - Trichuridae
KW - Trichuris
KW - Adenophorea
KW - Ascaridida
KW - dithiazanine
KW - Enoplida
KW - parasitic worms
KW - Rhabditida
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Age and infectivity of the filariform larvae of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914).
AU - HALEY, A. J.
AU - CLIFFORD, C. M.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1960///
VL - 46
IS - 5
SP - 579
EP - 582
SN - 0022-3395
AD - HALEY, A. J.: Public Health Service, National Institute of Allergy & Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.
N1 - Accession Number: 19610802260. Publication Type: Journal Article. Language: not specified.
N2 - Laboratory rats were inoculated intracutaneously with filariform larvae of Nippostrongylus muris three to 111 days old and were killed on the tenth day of infection. Larval age up to four weeks had little or no influence on the number of adult worms recovered; after this age the numbers varied and then decreased with increasing age. Only a few of the 111-day-old larvae developed into adults. N. Jones.
KW - infectivity
KW - laboratory animals
KW - laboratory mammals
KW - larvae
KW - small mammals
KW - Nippostrongylus
KW - Nippostrongylus brasiliensis
KW - rats
KW - Heligmonellidae
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Nippostrongylus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - small mammals
KW - Secernentea
KW - Strongylida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The use of formalinized red cells in the serology of hydatid disease.
AU - ALLAIN, D. S.
AU - KAGAN, I. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1961///
VL - 47
IS - 1
SP - 61
EP - 64
SN - 0022-3395
AD - ALLAIN, D. S.: Department of Health, Education and Welfare, United States Public Health Service, Communicable Disease Center, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19610802680. Publication Type: Journal Article. Language: not specified.
N2 - Allain & Kagan have prepared formalinized sheep erythrocytes by a modification of Csizmas' method [see Proc. Soc. exp. BioL, N.Y., 103, 157-160] and have sensitized them with tannic acid and coated them with Echinococcus antigen. Such sensitized cells were satisfactory for use in haemagglutination tests for two weeks when stored at 5oC., for six months when stored at -70°C. or for seven months when freeze-dried and stored at -20°C. J. W. Smith.
KW - antigens
KW - echinococcosis
KW - erythrocytes
KW - haemagglutination
KW - haemagglutination tests
KW - human diseases
KW - hydatids
KW - serology
KW - storage
KW - tannins
KW - Echinococcus
KW - Eucestoda
KW - man
KW - sheep
KW - Taeniidae
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ovis
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - ungulates
KW - antigenicity
KW - blood red cells
KW - hemagglutination
KW - hemagglutination tests
KW - hydatid disease
KW - hydatidosis
KW - immunogens
KW - red blood cells
KW - tannic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802680&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Another potential intermediate host snail for Schistosoma mansani in Puerto Rico.
AU - RICHARDS, C. S.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1961///
VL - 47
IS - 1
SP - 64
EP - 64
SN - 0022-3395
AD - RICHARDS, C. S.: Puerto Rico Field Station, Technology Branch, Communicable Disease Center, Public Health Service, United States Department of Health, Education and Welfare, San Juan, Puerto Rico.
N1 - Accession Number: 19610802474. Publication Type: Journal Article. Language: not specified.
N2 - A planorbid snail, which Richards states was identified morphologically as Tropicorbis riisei (which may be the same as T. peregrinus and T. havanensis), was exposed to Schistosoma mansoni miracidia; S. mansoni cercariae were shed 34 days later. Two offspring of this snail developed heavy infections when exposed to miracidia on six occasions over a period of about five months; only one snail shed cercariae.J. W. Smith.
KW - aquatic animals
KW - cercariae
KW - freshwater molluscs
KW - infections
KW - intermediate hosts
KW - miracidia
KW - Puerto Rico
KW - Mollusca
KW - Planorbidae
KW - Schistosoma
KW - Schistosoma mansoni
KW - snails
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Gastropoda
KW - Mollusca
KW - snails
KW - aquatic animals
KW - aquatic organisms
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - Schistosoma
KW - Greater Antilles
KW - Caribbean
KW - America
KW - Developing Countries
KW - Latin America
KW - Porto Rico
KW - Strigeida
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802474&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies on the standardization of the intradermal test for the diagnosis of bilharziasis.
AU - KAGAN, I. G.
AU - PELLEGRINO, J.
AU - MEMORIA, J. M. P.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1961///
VL - 10
IS - 2
SP - 200
EP - 207
SN - 0002-9637
AD - KAGAN, I. G.: U.S. Department of Health, Public Health Service, Communicable Disease Center, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19610802106. Publication Type: Journal Article. Language: not specified.
N2 - Infants, children and adults infected with Schistosoma mansoni were injected intradermally with 0.05 ml. of antigen containing 20 to 60 gamma nitrogen per ml., the wheal was measured after 15 minutes and areas of 1.0 sq. cm. or more were recorded as positive reactions. Providing the nitrogen was adjusted to equal values antigens prepared in the U.S.A. and Brazil and by four methods showed equal reactivity. Children under five years were not satisfactory subjects. Girls reacted less strongly than boys and the response on the back of women was equal to that on the arm of men. The sensitivity on the arm was 75% whereas that on the back was 92%. S. Willmott.
KW - antigens
KW - boys
KW - children
KW - diagnosis
KW - girls
KW - human diseases
KW - infants
KW - infections
KW - schistosomiasis
KW - skin tests
KW - snail-borne diseases
KW - standardization
KW - trematode infections
KW - women
KW - Brazil
KW - USA
KW - man
KW - Schistosoma
KW - Schistosoma mansoni
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - South America
KW - America
KW - Developing Countries
KW - Threshold Countries
KW - Latin America
KW - North America
KW - Developed Countries
KW - OECD Countries
KW - antigenicity
KW - bilharzia
KW - bilharziasis
KW - fluke infections
KW - immunogens
KW - intradermal tests
KW - schistosomosis
KW - Strigeida
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19610802106&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - Laboratory manual for medical mycology.
AU - AJELLO, L.
AU - GEORG, LUCILLE K.
AU - KAPLAN, W.
AU - KAUFMAN, L.
T2 - Laboratory manual for medical mycology.
Y1 - 1962///
AD - AJELLO, L.: U.S. Dept of Health, Education and Welfare. Public Health Service, Communicable Disease Center, Atlanta 22, Georgia.
N1 - Accession Number: 19631301459. Publication Type: Book. Language: not specified.
N2 - This useful and comprehensive manual [available on request from Communicable Disease centre, Atlanta, Ga] is composed of the following sections: Introduction to medical mycology, Study of the saprophytic fungi, Superficial mycoses, Cutaneous mycoses, The yeast-like fungi, Subcutaneous mycoses, Systemic mycoses, The rare mycoses, Use of fluorescent antibody techniques in medical mycology, and an appendix (including staining and culture techniques, a glossary, a list of general mycology texts. and a 32-page bibliography).
KW - bibliographies
KW - culture techniques
KW - glossaries
KW - infections
KW - medical mycology
KW - mycoses
KW - staining
KW - techniques
KW - Georgia
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Southeastern States of USA
KW - superficial mycoses
KW - terminologies
KW - United States of America
KW - Information and Documentation (CC300)
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Histoplasma endocarditis. Case report and review of the literature.
AU - HARTLEY, R. A.
AU - REMSBERG, J. R. S.
AU - SINALY, N. P.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 1967///
VL - 119
IS - 5
SP - 527
EP - 531
SN - 0003-9926
AD - HARTLEY, R. A.: U.S. Public Health Service Hosp., Baltimore.
N1 - Accession Number: 19691301546. Publication Type: Journal Article. Language: not specified. Number of References: 27 ref. Registry Number: 1397-89-3.
N2 - Following presumptive diagnosis of histoplasma endocarditis the patient, a 37-yr-old man, was given amphotericin B, and responded well (total dose 1, 725 mg over 87 days), but died suddenly. Histoplasma capsulatum was seen in the hilar and media-stinal lymph nodes at autopsy. Lesions on the mitral valve showed evidence of healing. The cause of death was not established.
KW - amphotericin B
KW - antibiotics
KW - case reports
KW - causes of death
KW - diagnosis
KW - endocarditis
KW - literature reviews
KW - lymph nodes
KW - postmortem examinations
KW - Ajellomyces capsulatus
KW - Histoplasma
KW - Histoplasma capsulatum
KW - man
KW - Ajellomyces
KW - Gymnoascales
KW - Ascomycotina
KW - Eumycota
KW - fungi
KW - eukaryotes
KW - Deuteromycotina
KW - Histoplasma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - amphotericin
KW - autopsy
KW - Emmonsiella capsulata
KW - postmortem inspections
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19691301546&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Disseminated histoplasmosis with an oral lesion. Report of a case.
AU - BODEN, R. A.
JO - Oral Surgery
JF - Oral Surgery
Y1 - 1967///
VL - 23
IS - 4
SP - 549
EP - 556
AD - BODEN, R. A.: U.S. public Health Service, Danbury, Conn.
N1 - Accession Number: 19721300828. Publication Type: Journal Article. Language: not specified. Number of References: 22 ref. Registry Number: 1397-89-3.
N2 - A case, in a 61-yr-old white man, of disseminated Histoplasma capsulatum infection presenting as an ulcer of the tongue is reported. Treatment with relatively small doses of amphotericin B intravenously (2180 mg over 4 months) resulted in prompt regression of the granulomatous lesion with a minimum of side effects. A review of current literature on amphotericin B therapy is presented.
KW - adverse effects
KW - amphotericin B
KW - antibiotics
KW - ethnic groups
KW - granuloma
KW - histoplasmosis
KW - infections
KW - lesions
KW - mouth
KW - mouth diseases
KW - mycoses
KW - therapy
KW - tongue
KW - ulcers
KW - Ajellomyces capsulatus
KW - Histoplasma
KW - Histoplasma capsulatum
KW - man
KW - Ajellomyces
KW - Gymnoascales
KW - Ascomycotina
KW - Eumycota
KW - fungi
KW - eukaryotes
KW - Deuteromycotina
KW - Histoplasma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - adverse reactions
KW - amphotericin
KW - Caucasians
KW - Emmonsiella capsulata
KW - oral lesions
KW - therapeutics
KW - whites
KW - Pesticides and Drugs (General) (HH400)
KW - Social Structure (UU480) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Histoplasma ulcer of the tongue.
AU - HILEY, P.
AU - HEILBRUNN, C.
AU - FIELDS, J.
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
Y1 - 1967///
VL - 200
IS - 12
SP - 1130
EP - 1131
AD - HILEY, P.: Href. U.S. Public Health Service Hosp., Staten Island, N.Y.
N1 - Accession Number: 19691301537. Publication Type: Journal Article. Language: not specified. Registry Number: 1397-89-3.
N2 - A 61-yr-old white man with disseminated Histoplasma capsulatum infection presenting as an ulcer of the tongue was treated successfully with relatively low doses of amphotericin B (10 mg/48 hr increasing to 35 mg/48 hr, total dose 2, 530 mg in 5 months) with a minimum of side effects.
KW - adverse effects
KW - amphotericin B
KW - antibiotics
KW - ethnic groups
KW - tongue
KW - ulcers
KW - Ajellomyces capsulatus
KW - Histoplasma
KW - Histoplasma capsulatum
KW - man
KW - Ajellomyces
KW - Gymnoascales
KW - Ascomycotina
KW - Eumycota
KW - fungi
KW - eukaryotes
KW - Deuteromycotina
KW - Histoplasma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - adverse reactions
KW - amphotericin
KW - Caucasians
KW - Emmonsiella capsulata
KW - whites
KW - Pesticides and Drugs (General) (HH400)
KW - Social Structure (UU480) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19691301537&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - Controlled release formulations for use against Aedes aegypti.
AU - TAYLOR, R. T.
AU - MILES, J. W.
AU - GUERRANT, G. O.
AU - BROOKS, G. D.
T2 - Proceedings. New Jersey Mosquito Extermination Association, 1969
JO - Proceedings. New Jersey Mosquito Extermination Association, 1969
JF - Proceedings. New Jersey Mosquito Extermination Association, 1969
Y1 - 1969///
SP - 80
EP - 86
AD - TAYLOR, R. T.: Technical Development Laboratories, National Communicable Disease Center, Public Health Service, Department of Health, Education and Welfare, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000439. Publication Type: Conference paper. Language: not specified. Registry Number: 18181-70-9, 14816-18-3.
N2 - In tests of 16 formulations of difenphos (Abate) and two each of phoxim (Bay 77488) and iodofenphos (C-9491) for the control of larvae of Aedes aegypti (L.) in drinking water in storage drums, samples of the various formulations containing 0.2-10 g technical material were introduced into outdoor storage drums [cf. RAE B56 607] giving maximum possible dosages ranging from 1 to 50 p.p.m. Difenphos gave 90% kill of dieldrin-resistant third-instar larvae for 10-20 weeks on solid or foam polyvinyl chloride granules according to dosage, for 2 weeks on nylon granules without a surface-active agent but for 20 weeks with such an agent, for 16 weeks on neoprene rubber granules, and for 20 weeks at a concentration of 1% on sand granules or in ethanol solution. Iodofenphos in solid polyvinyl chloride was effective for 8 weeks and in ethanol for 6 weeks. Phoxim in solid polyvinyl chloride was effective for 10 weeks and in ethanol for only two weeks. Chemical analysis of water samples showed high initial concentrations of the compounds from granular formulations and ethanol solutions, with a rapid decrease between 48 h and two weeks after treatment. The effectiveness of the granules varied little from treatment to breakpoint. Water treated with 50 p.p.m. difenphos in solid polyvinyl chloride contained 0.007 p.p.m. in the twentieth week, and other water giving satisfactory kills at this time contained 0.001-0.005 p.p.m.
KW - controlled release
KW - drinking water
KW - effects
KW - jodfenphos
KW - larvae
KW - phoxim
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - iodofenphos
KW - mosquitoes
KW - slow release
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000439&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The bionomics of Lankesteria culicis and Aedes aegypti.
AU - McCRAY, E. M.
AU - Jr.
AU - FAY, R. W.
AU - SCHOOF, H. F.
JO - Journal of Invertebrate Pathology
JF - Journal of Invertebrate Pathology
Y1 - 1970///
VL - 16
IS - 1
SP - 42
EP - 53
SN - 0022-2011
AD - McCRAY, E. M.: Technical development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001823. Publication Type: Journal Article. Language: English. Number of References: 6 ref.
N2 - The following is based largely on the authors' summary. In order to evaluate Lankesteria culicis as a potential biological control agent for Aedes aegypti (L.), laboratory studies were carried out [cf. RAE B 58 794, etc.]. The effect on larval development, size, mortality, synchrony of larval development, pupation, pupal weight, adult emergence, survival, spore excretion and egg production was examined. No significant pathological effects on A. aegypti could be demonstrated, although the life-span of infected females was somewhat reduced. Other workers have recorded considerable mortality and damage as a result of infestation with this parasite [cf. loc. cit.].
KW - biological control
KW - biological control agents
KW - biology
KW - developmental stages
KW - ecology
KW - egg production
KW - larvae
KW - lifespan
KW - mortality
KW - survival
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Lankesteria culicis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Lankesteria
KW - Lecudinidae
KW - Eugregarinorida
KW - Apicomplexa
KW - Protozoa
KW - biocontrol agents
KW - biological control organisms
KW - death rate
KW - growth phase
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Control (HH100)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Animal Ecology (ZZ332)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001823&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - An evaluation of five serologic tests for the diagnosis of trichinosis in lightly infected swine.
AU - KAGAN, I. G.
AU - QUIST, K. D.
A2 - Singh, K. S.
A2 - TANDAN, B. K.
T2 - An evaluation of five serologic tests for the diagnosis of trichinosis in lightly infected swine.
Y1 - 1970///
PB - Izatnagar U.P.: Indian Veterinary Research Institute
AD - KAGAN, I. G.: National Communicable Disease Centre, Public Health Service, Bureau of Disease Prevention and Environmental Control, U.S. Dept. of Health, Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19720891979. Publication Type: Book. Language: English.
N2 - Ten pigs were given 25 Trichinella spiralis larvae and 3 were given 50000; the mean number of larvae per g. of diaphragm at autopsy was 0.27 and 1, 561, respectively. Serological tests were carried out on the pigs; 2 of the 3 heavily infected animals were positive at the end of the first week and all 3 by the end of the 2nd. whereas the lightly infected animals did not give positive results until week 7. The fluorescent antibody technique gave the highest sensitivity and specificity. Other tests used, in descending order of value, were the Suessenguth-Kline test, latex test and charcoal card test. The bentonite flocculation test was insensitive. D.A.Cz.
KW - charcoal
KW - diagnosis
KW - diaphragm
KW - helminths
KW - immunofluorescence
KW - immunological techniques
KW - infections
KW - latex
KW - nematode infections
KW - postmortem examinations
KW - serology
KW - trichinosis
KW - Nematoda
KW - pigs
KW - Trichinella
KW - Trichinella spiralis
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - ungulates
KW - Trichinellidae
KW - Nematoda
KW - Trichinella
KW - Adenophorea
KW - autopsy
KW - Enoplida
KW - fluorescent antibody technique
KW - hogs
KW - IFAT
KW - parasitic worms
KW - postmortem inspections
KW - serological techniques
KW - swine
KW - trichinellosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19720891979&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - GEN
T1 - Studies on the helminth fauna of Alaska. XLV. Schistotaenia srivastavai n.sp. (Cestoda: Amabiliidae) from the red-necked grebe, Podiceps grisegena (Boddaert).
AU - RAUSCH, R. L.
A2 - SINGH, K. S.
A2 - TANDAN, B. K.
T2 - Studies on the helminth fauna of Alaska. XLV. Schistotaenia srivastavai n.sp. (Cestoda: Amabiliidae) from the red-necked grebe, Podiceps grisegena (Boddaert).
Y1 - 1970///
PB - Izatnagar, U.P.: Indian Veterinary Research Institute.
AD - RAUSCH, R. L.: Arctic Health Research Centre, Public Health Service, U.S. Dept. of Health, Education & Welfare, College, Alaska 99701, USA.
N1 - Accession Number: 19720801871. Publication Type: Book. Language: English.
N2 - Schistotaenia srivastavai n.sp. is described from the small intestine of Podiceps grisegena holboellii at Anchorage, Alaska, USA. It is characterized by the small size of the strobila, by the small hooks and by the relatively large cirrus sac. Additional characters which distinguish it from the 6 other species of the genus are given. A mixed infection of Schistotaenia spp., namely, S. srivastavai and S. colymba, was recorded for the first time from P. grisegena holboellii in Anchorage. Data on the occurrence of Schistotaenia spp. in grebes in North America are given. The attachment of the cestpde to the intestinal wall of the host is briefly mentioned. A.J.
KW - fauna
KW - helminths
KW - infections
KW - intestines
KW - mixed infections
KW - new species
KW - parasites
KW - small intestine
KW - taxonomy
KW - Alaska
KW - America
KW - North America
KW - USA
KW - Cestoda
KW - Podiceps
KW - Podiceps grisegena
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Podicipedidae
KW - Podicipediformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Podiceps
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - hooks
KW - multiple infections
KW - parasitic worms
KW - strobila
KW - systematics
KW - United States of America
KW - Biological Resources (Animal) (PP710)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19720801871&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Review of biological control methods for schistosome-bearing snails.
AU - Ferguson, F. F.
AU - Ruiz-Tiben, E.
JO - Ethiopian Medical Journal
JF - Ethiopian Medical Journal
Y1 - 1971///
VL - 9
IS - 2
SP - 95
EP - 104
SN - 0014-1755
AD - Ferguson, F. F.: San Juan Laboratories, Center for Disease Control, US Public Health Service, P.O.Box 52, Old San Juan, Puerto Rico 00902.
N1 - Accession Number: 19730803298. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - In this review of the biological control of schistosome-transmitting snails, Ferguson & Ruii-Tiben briefly quote from investigations of snail control by predators. These include the marsh flies (family Sciomyzidae), the snails Marisa and Pomacea, the turtle Pseudemys scripta elegans and the fish Astatoreochromis, Tilapia spp., Ctenopharyngodon idella, Haplochromis and Lepomis microlophus. Other biological methods described are intermittent drying by manipulation of water levels, and direct competition between related snails, e.g. Biomphalaria riisei and Helisoma caribbeum. Projects for further investigation in Ethiopia are suggested using some of these methods. Distribution and ecology of schistosome-transmitting snails in Ethiopia is briefly described. This useful review includes 56 references.
KW - biological control
KW - control
KW - ecology
KW - helminths
KW - intermediate hosts
KW - natural enemies
KW - parasites
KW - reviews
KW - Ethiopia
KW - MOLLUSCA
KW - Schistosoma
KW - snails
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - Gastropoda
KW - Mollusca
KW - ACP Countries
KW - East Africa
KW - Africa South of Sahara
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - Abyssinia
KW - biocontrol
KW - Molluscs
KW - parasitic worms
KW - secondary hosts
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Biological Control (HH100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730803298&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies of carbamate pesticide metabolism utilizing plant and mammalian cells in culture.
AU - Locke, R. K.
AU - Bastone, V. B.
AU - Baron, R. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1971///
VL - 19
IS - 6
SP - 1205
EP - 1209
SN - 0021-8561
AD - Locke, R. K.: Division of Pesticide Chemistry and Toxicology, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19730506812. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 63-25-2. Subject Subsets: Agricultural Entomology
N2 - One experimental and two commercial carbamate insecticides (carbaryl, carbanolate (Banol) and UC-34096 (N'-(4-methylcarbamoyloxy-O-tolyl)-N,N-dimethylformamidine [also known as 4-(((dimethylamino)methylene)amino)-m-tolyl methylcarbamate])), labelled with 14C in selected positions, were introduced into the medium of human embryonic lung or tobacco cells in culture. Lung cells hydrolysed carbanolate to the phenol, which was then conjugated as an O-glucuronide. UC-34096 was not metabolised by lung cells, but formed a spontaneous decomposition product. Tobacco cells in suspension culture incorporated 21% of the added carbaryl. A significant amount of the incorporated label was associated with cell debris following homogenisation. The remaining label contained in the supernatant fraction consisted of an unidentified organoextractable metabolite, neutral conjugates of carbaryl, alpha -naphthol and 5,6-dihydro-5,6-dihydroxycarbaryl, and acidic conjugates of carbaryl and alpha -naphthol.
KW - agricultural entomology
KW - carbamates
KW - carbaryl
KW - metabolism
KW - pesticides
KW - tobacco
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - carbanolate
KW - ester with N'-(4-hydroxy-o-tolyl)-N,N-dimethylformamidine
KW - methyl carbamic acid
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730506812&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public Health Pesticides.
JO - Pest Control
JF - Pest Control
Y1 - 1971///
VL - 39
IS - 3
SP - 13...51
EP - 13...51
SN - 0031-6121
AD - Center for Disease Control, Public Health Service, P.O. Box 2167, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19720502141. Publication Type: Journal Article. Corporate Author: Center for Disease Control Language: English. Number of References: 6 ref. Registry Number: 12002-03-8, 62-73-7. Subject Subsets: Medical & Veterinary Entomology
N2 - This 1971 report from the Center for Disease Control [formerly the National Communicable Disease Center] of the United States Department of Health, Education and Welfare continues an annual series under the same title [cf. RAE/B 60, 1097, etc.] giving information on the current use of pesticides for control of arthropods and rodents in the United States together with the results of pesticide investigations made at the Center and elsewhere. It includes sections on mosquitos (Aedes, Anopheles and Culex), flies (Musca, Fannia and Stomoxys), fleas (Xenopsylla cheopis (Roths.), Pulex irritans L. and Ctenocephalides spp.), bedbugs (Cimex), ticks (Dermacentor variabilis (Say), Rhipicephalus sanguineus (Latr.) and Amblyomma americanum (L.)), mites (Trombiculids), lice (Pediculus humanus humanus L., P. h. capitis Deg. and Phthirus pubis (L.)), cockroaches (Blattella germanica (L.)), venomous arthropods (scorpions, spiders and wasps) and rodents. Introductory sections deal with prohibited and restricted pesticides and with hazards, and the acute oral and dermal LD50's for rats of 23 common pesticides are tabulated.The section on mosquitos includes an account of the results from ultra-low-volume applications of thermal and non-thermal aerosols of insecticides from aircraft and from the ground against adults and larvae, and also of the results from tests of residual spray deposits, dusts and a slow-release formulation of dichlorvos against adults and from tests of paris green and oils against larvae. The pesticides currently used for mosquito control are tabulated, with the recommended dosages and methods of application, and also the LC95's of 12 insecticides for mosquitos resistant to chlorinated hydrocarbons. The section on flies deals mainly with the use of residual spray deposits, impregnated cords, poison baits and sprays against the adults and of sprays or pelleted formulations against the larvae, though tests of insecticides fed to cattle are also described. A table showing the organophosphate compounds currently used for fly control, with recommended dosages and methods of application, is included. In the section on fleas, attention is drawn to two special problems. One is the need to prevent the importation of these insects in aircraft and the containers carried by cargo ships, and the results of disinsection tests with dichlorvos and micronised dusts of organophosphates are described. The other is the need to control epizootics of plague in the field before human infections occur; tests of methods of controlling fleas on wild rodents by use of bait in boxes treated with insecticide and of bait containing a systemic insecticide are described. In the remaining sections, established and experimental methods of controlling the other arthropod pests are described.
KW - aircraft
KW - chemical control
KW - control
KW - COPPER ACETOARSENITE
KW - dichlorvos
KW - pest control
KW - pesticides
KW - plague
KW - usage
KW - USA
KW - Aedes
KW - Amblyomma americanum
KW - Anopheles
KW - ARANEAE
KW - Blattella germanica
KW - Cimex
KW - Ctenocephalides
KW - Culex
KW - Culicidae
KW - Dermacentor variabilis
KW - Fannia
KW - insects
KW - Musca
KW - PEDICULUS CAPITIS
KW - Pediculus humanus
KW - Pthirus
KW - Pthirus pubis
KW - Pulex irritans
KW - Rhipicephalus sanguineus
KW - rodents
KW - Scorpiones
KW - Siphonaptera
KW - Stomoxys
KW - Trombiculidae
KW - VESPIDAE
KW - Xenopsylla cheopis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Amblyomma
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - Blattella
KW - Blattellidae
KW - Blattaria
KW - Dictyoptera
KW - Cimicidae
KW - Heteroptera
KW - Hemiptera
KW - Pulicidae
KW - Siphonaptera
KW - Dermacentor
KW - Fanniidae
KW - Muscidae
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - Pthirus
KW - Pthiridae
KW - Pulex
KW - Rhipicephalus
KW - mammals
KW - vertebrates
KW - Chordata
KW - Prostigmata
KW - mites
KW - Hymenoptera
KW - Xenopsylla
KW - Pediculus humanus
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Blattodea
KW - body louse
KW - crab louse
KW - DDVP
KW - German cockroach
KW - head louse
KW - human flea
KW - lone star tick
KW - mosquitoes
KW - Oriental rat flea
KW - paris green
KW - Pediculus humanus capitis
KW - Pediculus humanus humanus
KW - Phthirus
KW - Phthirus pubis
KW - Rhiephalus sanguineus
KW - spiders
KW - United States of America
KW - wasps
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720502141&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improvement of the AOAC kilogram sample method for the isolation of aflatoxin B1 for chemical and biological confirmation.
AU - Stack, M.
AU - Rodricks, J. V.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 6
SP - 1310
EP - 1312
AD - Stack, M.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19721301424. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology
N2 - An acid alumina column substituted for the 10 g silica gel column eliminates the only residue which interferes with preparative TLC. Time is saved by processing only enough extract to yield the required amount of aflatoxin. On applying the procedure to aflatoxin-contaminated peanut butter, Brazil nuts, cottonseed meal and maize, aflatoxin B1 extracts were obtained showing only 1 spot on TLC plates and gave positive derivative and Bacillus megaterium tests.
KW - aflatoxins
KW - detection
KW - isolation
KW - mycotoxins
KW - fungal toxins
KW - thin-layer chromatography
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19721301424&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fading of aflatoxin spots on TLC plates during fluorescence densitometry.
AU - Nesheim, S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 6
SP - 1444
EP - 1445
AD - Nesheim, S.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19721301425. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology
N2 - The lamp-coding effluent from the high intensity xenon lamp light source of a spectrofluorometer TLC plate scanner reduced the fluorescence of aflatoxin B1 and G1 by c. 90% and of aflatoxins B2 and G2 by <25%. The fading can be prevented by covering the plate with another glass plate.
KW - aflatoxins
KW - detection
KW - mycotoxins
KW - fungal toxins
KW - thin-layer chromatography
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19721301425&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The distribution, ethology and control potential of the Lankesteria culicis (Ross)-Aedes aegypti (L.) complex in southern United States.
AU - GENTILE, A. G.
AU - FAY, R. W.
AU - McCRAY, E. M.
AU - Jr.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 1
SP - 12
EP - 17
AD - GENTILE, A. G.: Technical Development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000026. Publication Type: Journal Article. Language: English. Number of References: 15 ref.
N2 - The following is based largely on the authors' summary. During surveys in the southern United States in the spring, summer and autumn of 1968, infection of Aedes aegypti (L.) with the Protozoan parasite Lankesteria culicis [cf. RAE B 58 794, etc.] was found to occur in all the known areas inhabited by the mosquito, except in a few urban areas into which A, aegyptihad been recently introduced and areas of transient infestation by the mosquito. The seasonal incidence of the parasite was related to seasonal changes in the population density of the host. The observations suggested that Lankesteria was host-specific, and it apparently had little deleterious effect on the host populations. There were temporary increases in the rate of infection in natural populations of A. aegypti following the introduction of sporocysts of Lankesteria from laboratory cultures, but the symbiotic balance of the host-parasite complex was rapidly re-established.
KW - incidence
KW - population density
KW - seasonal variation
KW - seasonality
KW - surveys
KW - urban areas
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Lankesteria culicis
KW - Protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Lankesteria
KW - Lecudinidae
KW - Eugregarinorida
KW - Apicomplexa
KW - Protozoa
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - mosquitoes
KW - seasonal changes
KW - seasonal fluctuations
KW - sporocysts
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000026&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Collaborative study of the hemoglobin repletion test in chicks and rats for measuring availability of iron.
AU - PLA, G. W.
AU - FRITZ, J. C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 1
SP - 13
EP - 17
AD - PLA, G. W.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721406163. Publication Type: Journal Article. Language: English. Registry Number: 7439-89-6.
N2 - A collaborative study with 8 laboratories was used to assess the availability of Fe by the authors' method (Abst. 3150, Vol. 41) with chickens or with rats. Chickens and rats were satisfactorily depleted when Hb was less than 5 and 6 g/100 ml blood and haematocrit was less than 24 and 29%, respectively. Hb or haematocrit was a suitable measure of repletion. Relative to FeSO4. 7H2O taken as 100 values were ferric phosphate 12± 10.9, sodium iron pyrophosphate containing 14.5% Fe 13± 7.7, reduced Fe 46± 17.9 and ferrous carbonate ores containing 38% Fe 3 4.5. The substances were ranked in the same order when plasma Fe of volunteers was estimated. The Hb repletion test was recommended for adoption as official first action.-A. H.
KW - animal models
KW - chicks
KW - haemoglobin
KW - iron
KW - poultry
KW - fowls
KW - rats
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - poultry
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - small mammals
KW - chickens
KW - domesticated birds
KW - hemoglobin
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (General) (LL500)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Field studies on Lankesteria culicis and Aedes aegypti in Florida.
AU - STAPP, R. R.
AU - CASTEN, J.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 1
SP - 18
EP - 22
AD - STAPP, R. R.: Technical Development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000027. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 50-29-3.
N2 - The following is based largely on the authors' summary. During surveys in Florida in three periods of 1968, infection of Aedes aegypti (L.) with Lankesteria culicis was commonly found in cities [cf.preceding abstract]. The mean number of trophozoites per infected Aedeslarva was 57. Heavily infected larvae (with 200-800 trophozoites per insect) did not seem to be markedly adversely affected by the parasitism. The levels of the infection in A. aegypti were increased by the introduction of sporocysts of Lankesteria into 'breeding sites of the mosquito. It was shown that heavy infection with Lankesteria in larvae of a DDT-resistant natural population of A. aegypti was associated with increased susceptibility of the larvae to DDT, but the increase in mortality is of questionable economic value.
KW - DDT
KW - economics
KW - infections
KW - larvae
KW - mortality
KW - pesticide resistance
KW - pesticides
KW - surveys
KW - trophozoites
KW - Florida
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Lankesteria culicis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Lankesteria
KW - Lecudinidae
KW - Eugregarinorida
KW - Apicomplexa
KW - Protozoa
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - death rate
KW - dicophane
KW - mosquitoes
KW - sporocysts
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000027&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Distribution in Texas of Lankesteria culicis(Ross), a parasite of Aedes aegypti(L.).
AU - BARRETT, W. J.
AU - Jr.
AU - MILLER, F. M.
AU - KLIEWER, J. W.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 1
SP - 23
EP - 27
AD - BARRETT, W. J.: Technical Development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000028. Publication Type: Journal Article. Language: English. Number of References: 4 ref.
N2 - The following is substantially the authors' summary. The results of surveys in Houston, Texas, in the spring, summer and autumn of 1968 showed that of some 3300 larvae of Aedes aegypti (L.) dissected, 592 were infected with Lankesteria culicis [cf.preceding abstract, etc.], with a mean of 80.7 trophozoites per larva. Individual rates of infection built up between spring and autumn but there was little change during the winter of 1967-68. The infection was not detected in larvae of A. aegypti in Corpus Christi, Texas, during the spring survey, but, when sporocysts of Lankesteria were placed in containers in which A. aegypti was breeding, the parasite became established and there was evidence of limited dispersal.
KW - infections
KW - larvae
KW - seasonality
KW - surveys
KW - trophozoites
KW - winter
KW - Texas
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Lankesteria culicis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Lankesteria
KW - Lecudinidae
KW - Eugregarinorida
KW - Apicomplexa
KW - Protozoa
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Great Plains States of USA
KW - Gulf States of USA
KW - mosquitoes
KW - sporocysts
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000028&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Distribution and density of Aedes aegypti (L.) and Lankesteria culicis (Ross) in Louisiana and adjoining areas.
AU - HAYES, G. R.
AU - Jr.
AU - HAVERFIELD, L. E.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 1
SP - 28
EP - 32
AD - HAYES, G. R.: Technical Development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000029. Publication Type: Journal Article. Language: English. Number of References: 4 ref.
N2 - The following is substantially the authors' summary. Surveys were conducted in 1968 on the distribution, density and effects on Aedes aegypti (L.) of infection with Lankesteria culicis [cf.preceding abstract, etc.] in an area extending from Temple, Texas, to Pensacola, Florida. The parasite was found in the greatest numbers and was most widely distributed where the populations of A. aegypti were greatest. There was no indication that parasitism exerted a serious limiting effect on the population of A. aegypti .However, infection with L. culicis might result in potentiation of the deleterious effects of other parasites or of insecticides on A. aegypti or reduce the ability of the infected individual to cope with adverse environmental factors.
KW - environmental factors
KW - insecticides
KW - parasites
KW - pesticides
KW - public health
KW - surveys
KW - Florida
KW - Louisiana
KW - Texas
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Lankesteria culicis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Lankesteria
KW - Lecudinidae
KW - Eugregarinorida
KW - Apicomplexa
KW - Protozoa
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - West South Central States of USA
KW - Delta States of USA
KW - Southern Plains States of USA
KW - Great Plains States of USA
KW - environmental health
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Health and the Environment (VV500)
KW - Pesticides and Drugs (General) (HH400)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000029&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Chromatographic separation of free amino acids in table sirups.
AU - JOHNSON, A. R.
AU - CORLISS, R. L.
AU - FERNANDEZ-FLORES, E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 1
SP - 61
EP - 65
AD - JOHNSON, A. R.: Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721495052. Publication Type: Journal Article. Language: English.
N2 - Amino acids were eluted from Dowex 50 W-X8 resin with N NH4OH then water and the eluate was evaporated to dryness. They were then separated by thin-layer chromatography on silica gel or by gas-liquid chromatography of their N-trifluoroacetyl n-butyl esters.
KW - amino acids
KW - analysis
KW - analytical methods
KW - chromatography
KW - esters
KW - free amino acids
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721495052&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The efficacy of carbaryl, propoxur, Abate and methoxychlor as larvicides against field infestations of Aedes aegypti.
AU - WINDEGUTH, D. L. VON
AU - ELIASON, D. A.
AU - SCHOOF, H. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 1
SP - 91
EP - 95
AD - WINDEGUTH, D. L. VON: Technical Development Laboratories, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000041. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 63-25-2, 50-29-3, 121-75-5, 72-43-5, 114-26-1.
N2 - In tests on the control of natural populations of larvae, of Aedes aegypti (L.) in an area of 95 blocks in Perrine, Florida, 0.5, 1.25 and 2.5% sprays of carbaryl, propoxur and methoxy-DDT (methoxychlor) and 0.25% sprays of difenphos (Abate) were applied to containers in all premises in which at least ten containers were present; a 2.5% spray of malathion was used for comparison. Carbaryl and propoxur were not sufficiently effective two months after application to be considered for use as larvicides against A. aegypti .Methoxy-DDT and difenphos gave satisfactory control for two months. Malathion was the least effective compound. When compared with a 1.25% spray of DDT, 1.25 and 2.5% sprays of methoxy-DDT were superior, suggesting that the latter could be used as a substitute for DDT in the programme to eradicate A. aegypti from the United States. However, methoxy-DDT is more expensive than DDT.
KW - carbaryl
KW - DDT
KW - infestation
KW - larvae
KW - malathion
KW - methoxychlor
KW - ovicides and larvicides
KW - pesticides
KW - propoxur
KW - Florida
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - dicophane
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000041&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Separation of sugars by centrifugal microparticulate bed chromatography.
AU - ANACKER, R. L.
AU - SIMMONS, J. H.
AU - RIBI, E.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1971///
VL - 62
IS - 1
SP - 93
EP - 97
SN - 0021-9673
AD - ANACKER, R. L.: US Dept. Health, Education and Welfare, Public Health Service, National Inst. Allergy and Infectious Diseases, Rocky Mountain Lab., Hamilton, Mont. 59840.
N1 - Accession Number: 19721495010. Publication Type: Journal Article. Language: English.
N2 - The sample was added to silica gel in a column, 3 X 50 mm. Solvent was added to the reservoir above and the apparatus was centrifuged at 2500 g. The extruded column was dried at 60o for about 10 min. Sugars were located by spraying with H2SO4 saturated with Na2Cr2O7 and heating; amino sugars were located by spraying with ninhydrin.-A. H.
KW - analytical methods
KW - chromatography
KW - sugars
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721495010&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Eastern equine encephalomyclitis virus : an electron microscopic study of Aedes triseriatus (Say) salivary gland infection.
AU - WHITFIELD, S. G.
AU - MURPHY, F. A.
AU - SUBIA, W. D.
JO - Virology
JF - Virology
Y1 - 1971///
VL - 43
IS - 1
SP - 110
EP - 122
SN - 0042-6822
AD - WHITFIELD, S. G.: Public Health Service, Center for Disease Control, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19721000332. Publication Type: Journal Article. Language: English. Number of References: 34 ref.
KW - salivary glands
KW - Aedes
KW - Aedes triseriatus
KW - Culicidae
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus triseriatus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000332&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Induction and repression of microsomal mixed-function oxidases and cytochrome P-450 in resistant and susceptible honseflies (Musca domesticaL.).
AU - PERRY, A. S.
AU - DALE, W. E.
AU - BUCKNER, A. J.
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
Y1 - 1971///
VL - 1
IS - 2
SP - 131
EP - 142
SN - 0048-3575
AD - PERRY, A. S.: Technical Development Laboratories, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Box 2167, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000929. Publication Type: Journal Article. Language: English. Number of References: 43 ref.
KW - cytochrome P-450
KW - Musca
KW - Muscidae
KW - Muscidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000929&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Gas-liquid chromatography of twenty protein amino acids on a single column.
AU - Moss, C. W.
AU - LAMBERT, M. A.
AU - DIAZ, F. J.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1971///
VL - 60
IS - 1
SP - 134
EP - 136
SN - 0021-9673
AD - Moss, C. W.: Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Dept. Health, Education and Welfare, Atlanta, Ga. 30333.
N1 - Accession Number: 19721492659. Publication Type: Journal Article. Language: English.
N2 - The N-heptafluorobutyryl n-propyl derivatives of 20 amino acids were separated in 43 min by chromatography on a column containing 3% siloxane (OV-1). A. H.
KW - amino acids
KW - analytical methods
KW - chromatography
KW - derivatives
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721492659&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - EEG of rhesus monkeys following prolonged low-level feeding of pesticides.
AU - SANTOLUCITO, J. A.
AU - MORRISON, G.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1971///
VL - 19
IS - 2
SP - 147
EP - 154
SN - 0041-008X
AD - SANTOLUCITO, J. A.: Perrine Primate Research Branch, Division of Pesticide Chemistry and Toxicology, Food and Drug Administration, Dept. Health, Education, and Welfare, Fla. 33157, USA.
N1 - Accession Number: 19721493776. Publication Type: Journal Article. Language: English.
KW - animal models
KW - feeding
KW - pesticides
KW - Macaca
KW - Macaca mulatta
KW - monkeys
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Macaca
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (General) (LL500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721493776&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Determination of mercury in fish by flameless atomic absorption: a collaborative study.
AU - MUNNS, R. K.
AU - HOLLAND, D. C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 1
SP - 202
EP - 205
AD - MUNNS, R. K.: Food and Drug Administration, 20th and California Sts., Denver, Colo. 80202, USA.
N1 - Accession Number: 19721405144. Publication Type: Journal Article. Language: English. Registry Number: 7439-97-6.
N2 - Recovery of inorganic Hg estimated in fish by 9 laboratories was by the method of flameless atomic absorption described 76, 79 and 87% for 3 samples with added Hg compared to 50, 41, 46% with the official AOAC method. Corresponding values for one sample with methyl Hg were 92 and 48%.-A. H.
KW - analysis
KW - estimation
KW - fish
KW - mercury
KW - methodology
KW - techniques
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721405144&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Effect of banol and parathion on operant learning behavior of rats fed adequate and inadequate casein diets.
AU - CASTERLINE, J. L.
AU - Jr.
AU - BRODIE, R. E.
AU - SOBOTRA, T. J.
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
Y1 - 1971///
VL - 6
IS - 4
SP - 297
EP - 303
SN - 0007-4861
AD - CASTERLINE, J. L.: Division of Pesticide Chemistry and Toxicology, Bureau of Foods, Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19721406442. Publication Type: Journal Article. Language: English. Registry Number: 9000-81-1, 9001-66-5.
N2 - A synthetic diet containing 5 or 18% protein as casein without or with 1000 mg Banol/kg or 4 mg parathion/kg was given to appetite to 56 Osborne-Mendel rats for 11 weeks. The rats were trained to press a lever to avoid an electric shock 5 sec after a light and sound stimulus. The food intake of the rats given 5% casein with pesticides was less than that of those given 18% casein with pesticides. Cholinesterase and monoamine oxidase activities in cerebellum and cerebrum were not significantly affected by the diet low in casein or by pesticides in the diet. Rats given the diet with 5% casein and parathion had a poorer lever pressing performance than those not given pesticide or those given 18% casein and parathion. Banol in the diet with 5% casein almost completely inhibited lever pressing. Rats given the diet with 5% casein but without pesticide had a poorer lever pressing performance than those given the diet with 18% casein and Banol.-D. W. H. S.
KW - acetylcholinesterase
KW - amine oxidase (flavin-containing)
KW - animal models
KW - appetite
KW - brain
KW - casein
KW - diets
KW - food
KW - food intake
KW - pesticides
KW - synthetic diets
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - artificial diets
KW - cerebrum
KW - Animal Models of Human Nutrition (VV140)
KW - Food Science and Food Products (Human) (QQ000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721406442&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Natural population dynamics of Phlebotomine sandflies in Panama.
AU - CHANIOTIS, B. N.
AU - NEELY, J. M.
AU - CORREA, M. A.
AU - TESH, R. B.
AU - JOHNSON, K. M.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1971///
VL - 8
IS - 4
SP - 339
EP - 352
SN - 0022-2585
AD - CHANIOTIS, B. N.: U.S. Public Health Service, Middle America Research Unit, Balboa Heights, Panama Canal Zone.
N1 - Accession Number: 19721000641. Publication Type: Journal Article. Language: English. Number of References: 28 ref.
N2 - The following is substantially the authors' abstract. The population dynamics of Phlebotomids were studied in a forest in Panama from January 1969 to April 1970. Populations were characterized by high species diversity, spatial heterogeneity and temporal change. Thirty-seven species were identified among 60 455 examples collected. Of these, 38.7% were caught in light-traps set near the ground and 12.5%in light-traps in trees, and 48.8% were collected in resting sites on tree trunks and buttresses [cf. RAE B 54 105]. The 7 anthropophilic species taken [cf. 60 653] formed 31.2% of the total catch, with light-traps attracting nearly twice as many near the ground as in the forest canopy. Collecting stations in three distinct habitats showed identical species composition but marked quantitative differences. Mature forest was a more productive Phlebotomid habitat than secondary forest and, within mature forest, a hilltop was more productive than a stream bed. Phlebotomids were present throughout the year but showed marked seasonal fluctuations. Temporal density changes were related to the amount and distributional pattern of rainfall, which apparently acted by modifying the developmental conditions in the ground [cf. 25 95]. Dryness or waterlogging of the forest floor, caused by scanty or excessive rainfall, coincided with reduced adult density. Peak activity occurred during the first week of August, with a second peak during the first half of January. The maximum increase, over the low dry season level, was about fivefold for the general population and eightfold for the anthropophilic species.
KW - animal behaviour
KW - behaviour
KW - dry season
KW - forest litter
KW - light traps
KW - population dynamics
KW - rain
KW - resting places
KW - seasonal variation
KW - species diversity
KW - Panama
KW - man
KW - Phlebotominae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Psychodidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Central America
KW - America
KW - Developing Countries
KW - Threshold Countries
KW - Latin America
KW - animal behavior
KW - behavior
KW - duff
KW - rainfall
KW - seasonal changes
KW - seasonal fluctuations
KW - Animal Behaviour (LL300)
KW - Animal Ecology (ZZ332)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000641&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The relative effectiveness of malathion thermal aerosols and ground-applied ULV against three species of mosquitoes.
AU - TAYLOR, R. T.
AU - SCHOOF, H. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 3
SP - 346
EP - 349
AD - TAYLOR, R. T.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000725. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 121-75-5.
N2 - The following is based largely on the authors' summary. In tests in open and wooded areas in Georgia in 1970, thermal aerosols and ultra-low-volume non-thermal aerosols of malathion were applied from a vehicle [cf. RAE B 58 172] against females of Anopheles albimanus Wied., Culex pipiens fatigans [Culex quinquefasciatus] Wied. (pipiens quinquefasciatus auct.) and Aedes taeniorhynchus (Wied.) exposed in cages suspended 6 ft above the ground and 150-600 ft from the point of discharge [cf. 58 149]. At a vehicle speed of 5 miles/h the ultra-low-volume aerosols of 95% malathion were applied at 1.7-4.1 fl oz/min and the thermal aerosols of 6 fl oz malathion/US gal fuel oil at 85 fl oz/min, and at a speed of 10 miles/h they were applied at 2.6-10 and 170 fl oz/min, respectively. At 5 miles/h in the open, flow rates of the ultra-low-volume aerosols of 3.9 and 4.1 fl oz/min were required to obtain kills of the three species similar to those obtained with the thermal aerosols. At 10 miles/h, flow rates of the ultra-low-volume aerosols of at least 4.3 fl oz/min were required to obtain kills similar to those obtained with the thermal aerosols at distances of up to 300 ft. The thermal aerosols were always superior to the ultra-low-volume aerosols in wooded sites.
KW - aerosols
KW - effects
KW - malathion
KW - pesticides
KW - ultralow volume spraying
KW - Georgia
KW - USA
KW - Aedes
KW - Aedes taeniorhynchus
KW - Anopheles
KW - Anopheles albimanus
KW - Culex
KW - Culex pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culex
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Southeastern States of USA
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus taeniorhynchus
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000725&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Venezuelanequine encephalitis in Texas, 1971. Informational report.
AU - SUDIA, W. D.
AU - NEWHOUSE, V. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 3
SP - 350
EP - 351
AD - SUDIA, W. D.: Center for Disease Control. Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19721000726. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 121-75-5.
N2 - An epidemie of Venezuclan equine encephalitis affecting 30 000-60 000 horses and some 20 000 humans occurred in Ecuador in the spring of 1969. The same disease was reported from Salvador and Guatemala in the following July and it subsequently spread to Honduras Nicaragua and Mexico [cf. RAE B 60 402, etc.]. By the summer of 1970. it had spread south into Costa Rica and north towards Tampico, Mexico. The first deaths of horses in the United States caused by the infection occurred in the Brownsville area of Texas in the first week of July 1971. By late July. 1937 sick and 1505 dead horses had been reported in Texas, mainly in the area south of San Antonio in the lower Rio Grande Valley. Fewer than 100 suspected human cases and no deaths had been reported by mid-July. The results of preliminary investigations suggested that at least 11 species of mosquitos were involved in the outbreak. The largest numbers of isolates resembling the virus of Venezuelan equine encephalitis were made from Aedes sollicitans (WJk.), Psorophora confinnis (Lynch Arrib.) and P. discolor (Coq.). Fewer isolates of virus were made from A. thelcter Dyar, Deinocerites pseudes D. & K., P. ciliata (F.), A. Taeniorhynchus (Wied.), P. cyanescens (Coq.), Culex (Melanoconiori) sp., C. salinarius Coq., Anopheles crucians Wied. and A. pseudopunctipennis Theo. By late July 1971, almost a million horses had been vaccinated against the disease in Texas, New Mexico, Oklahoma, Arkansas and Louisiana. Ultra-low-volume sprays of malathion were applied from aircraft against mosquitos in parts of Texas from the second week of July with generally apparently effective results.
KW - encephalitis
KW - human diseases
KW - infections
KW - malathion
KW - outbreaks
KW - pesticides
KW - ultralow volume spraying
KW - Arkansas
KW - Costa Rica
KW - Ecuador
KW - El Salvador
KW - Guatemala
KW - Honduras
KW - Louisiana
KW - New Mexico
KW - Nicaragua
KW - Oklahoma
KW - Texas
KW - USA
KW - Aedes
KW - Aedes sollicitans
KW - Anopheles
KW - Anopheles crucians
KW - Anopheles pseudopunctipennis
KW - Culex
KW - Culicidae
KW - Deinocerites
KW - horses
KW - man
KW - Psorophora
KW - Psorophora confinnis
KW - Venezuelan equine encephalitis virus
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - ungulates
KW - Homo
KW - Hominidae
KW - Primates
KW - Psorophora
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - West South Central States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Delta States of USA
KW - Central America
KW - Developing Countries
KW - Threshold Countries
KW - CACM
KW - Latin America
KW - South America
KW - Andean Group
KW - Gulf States of USA
KW - Mountain States of USA
KW - Western States of USA
KW - Great Plains States of USA
KW - Southwestern States of USA
KW - Southern Plains States of USA
KW - encephalomyelitis
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus sollicitans
KW - Salvador
KW - United States of America
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000726&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Field studies of Gardona against Aedes aegypti in Puerto Rico.
AU - REGNIER, A. V.
AU - Jr.
AU - CRANMER, M. F.
AU - LACOMBA, J. R.
AU - VELAZQUEZ, C.
AU - SCHOOF, H. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 3
SP - 360
EP - 370
AD - REGNIER, A. V.: Technical Development Laboratories, Genter for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721000729. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 9001-08-5, 22248-79-9, 961-11-5.
N2 - A detailed account is given of tests in the Corozal, Naranjito and Morovis districts of Puerto Rico in 1968 on the effectiveness of tetrachlorvinphos (Gardona) against larvae of Aedes aegypti (L.) when used as a suspension spray at a concentration of 1.25% during the first treatment cycle and at 2.5% during the second, 34-39 weeks later. Marked reductions resulted in the numbers of the larvae in treated containers in both rural and urban areas. However, rapid accumulation of new untreated containers occurred and could delay eradication of the species. For control operations, the compound would be used at the higher concentration. There were no adverse effects on the cholinesterase levels of persons involved in the application of the sprays.
KW - adverse effects
KW - cholinesterase
KW - control programmes
KW - effects
KW - larvae
KW - rural areas
KW - tetrachlorvinphos
KW - urban areas
KW - Puerto Rico
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - man
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Greater Antilles
KW - Caribbean
KW - America
KW - Developing Countries
KW - Latin America
KW - adverse reactions
KW - control programs
KW - mosquitoes
KW - Porto Rico
KW - stirofos
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000729&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Fetal growth retardation produced by experimental placental insufficiency in the rhesus monkey. 1. Body weight, organ size.
AU - MYERS, R. E.
AU - HILL, D. E.
AU - HOLT, A. B.
AU - SCOTT, R. E.
AU - MELLITS, E. D.
AU - CHEEK, D. B.
JO - Biology of the Neonate
JF - Biology of the Neonate
Y1 - 1971///
VL - 18
IS - 5/6
SP - 379
EP - 394
SN - 0006-3126
AD - MYERS, R. E.: Lab. Perinatal Physiology, National Inst. of Neurological Diseases and Stroke, US Public Health Service, Dept. Health, Education, and Welfare, Bethesda, Md. 20014.
N1 - Accession Number: 19721406337. Publication Type: Journal Article. Language: English.
N2 - 1. In 40 rhesus monkeys at 98 to 102 days of pregnancy, fetal umbilical vessels leading to the secondary placental disc were ligated; the young were delivered surgically at 156 to 160 days of gestation. There was a loss of about 60%, mainly by very premature birth of young which died; 16 experimental young were obtained, 3 by spontaneous delivery. Nine of those 16 had weights more than 2 SD below the normal regression line of weight for age. Few placentae were recovered but it appeared that the smallest foetuses were associated with the smallest placentae. Of tissues and organs studied, brain was least reduced by comparison with the control foetuses; adrenals, kidney and pituitary came next while the greatest reductions were shown by spleen and liver. The pattern of growth retardation in organs was similar to that in human intrauterine growth retardation.-D. L. D.
KW - adrenal glands
KW - animal models
KW - body weight
KW - brain
KW - fetal growth
KW - fetus
KW - growth retardation
KW - liver
KW - pituitary
KW - placenta
KW - pregnancy
KW - prematurity
KW - regression
KW - spleen
KW - Macaca
KW - Macaca mulatta
KW - man
KW - monkeys
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Macaca
KW - Homo
KW - Hominidae
KW - adrenals
KW - cerebrum
KW - foetal growth
KW - foetus
KW - gestation
KW - hypophysis
KW - pituitary gland
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721406337&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Field and laboratory studies on the hosts and vectors of the Snowshoe hare strain of California virus.
AU - NEWHOUSE, V. F.
AU - BURGDORFER, W.
AU - CORWIN, D.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 3
SP - 401
EP - 408
AD - NEWHOUSE, V. F.: Center for Disease Control, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19721000736. Publication Type: Journal Article. Language: English. Number of References: 15 ref.
N2 - The following is based largely on the authors' summary. A total of 319 small wild mammals representing ten species caught in the Bitter Root Mountains (mainly in Lost Horse Canyon) of Montana in 1960-63 was tested for the presence of antibodies neutralizing Snowshoe hare virus of the California encephalitis group [cf. RAE B 52 198; 58 1651]. Antibodies were found only in snowshoe hares (Lepus americanus) and golden-mantled ground squirrels (Spermophilus lateralis). In the laboratory, snowshoe hares, golden-mantled ground squirrels, chipmunks (Eutamias amoenus) and meadow voles (Microtus pennsylvanicus) developed moderate infections that persisted for up to 3 days after they had been infected experimentally. Inconsistent reactions were obtained with Columbian ground squirrels (S. columbianus) and bushy-tailed woodrats (Neotoma cinérea). Ground-hogs (Marmota flaviventris), an elk calf (Cervus canadensis [Cervus elaphus]), a beagle and white-footed mice (Peromyscus maniculatus) did not develop a detectable viraemia. All species, however, developed neutralizing antibodies against Snowshoe hare virus. A total of 19321 mosquitos of 14 species that was collected in traps baited with rabbits or goats in Lost Horse Canyon in 1962-63 was tested for the presence of virus. Five isolations of Snowshoe hare virus were made from pools of examples of Aedes fitchii (Felt & Young) collected in August-September 1962, and one was made from a pool of examples of Culiseta impatiens (Wlk.) collected in June 1963. Other aspects of the ecology of California encephalitis virus in the Bitter Root Mountains are discussed.
KW - ecology
KW - encephalitis
KW - infections
KW - neutralization
KW - neutralizing antibodies
KW - traps
KW - vectors
KW - wild animals
KW - California
KW - Montana
KW - USA
KW - Aedes
KW - Aedes fitchii
KW - California encephalitis virus
KW - Cervus
KW - Cervus elaphus
KW - Culicidae
KW - Culiseta
KW - deer
KW - dogs
KW - goats
KW - hares
KW - Lepus
KW - Lepus americanus
KW - Marmota
KW - mice
KW - Microtus
KW - Microtus pennsylvanicus
KW - Neotoma
KW - Peromyscus
KW - Peromyscus leucopus
KW - Peromyscus maniculatus
KW - rabbits
KW - red deer
KW - Sciuridae
KW - Snowshoe hare virus
KW - Spermophilus
KW - squirrels
KW - Tamias
KW - viruses
KW - voles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Cervidae
KW - deer
KW - ruminants
KW - Artiodactyla
KW - ungulates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Cervus
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - small mammals
KW - Capra
KW - Bovidae
KW - Leporidae
KW - Lagomorpha
KW - Lepus
KW - Sciuridae
KW - rodents
KW - squirrels
KW - Muridae
KW - Microtinae
KW - Microtus
KW - Hesperomyinae
KW - Peromyscus
KW - Cervus elaphus
KW - California encephalitis virus
KW - Culiseta
KW - Spermophilus
KW - Tamias
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Mountain States of USA
KW - Great Plains States of USA
KW - Culiseta impatiens
KW - encephalomyelitis
KW - mosquitoes
KW - Sciurinae
KW - Spermophilus lateralis
KW - Tamias amoenus
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Ecology (ZZ332)
KW - Host Resistance and Immunity (HH600)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000736&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Daily and seasonal man-biting activity of Phlebotomine sandflies in Panama.
AU - CHANIOTIS, B. N.
AU - CORREA, M. A.
AU - TESH, R. B.
AU - JOHNSON, K. M.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1971///
VL - 8
IS - 4
SP - 415
EP - 420
SN - 0022-2585
AD - CHANIOTIS, B. N.: U.S. Public Health Service, Middle America Research Unit, Balboa Heights, Panama Canal Zone.
N1 - Accession Number: 19721000653. Publication Type: Journal Article. Language: English. Number of References: 20 ref.
N2 - The following is substantially the authors' abstract. The daily and seasonal man-biting activity of seven anthropophilic species of Phlebotomids was recorded in a Panamanian forest over a period of a year [cf. RAE B 60 641]. Lutzomyia olmeca (Vargas & Díaz Nájera), L. panamensis (Shannon) and L. pessoana (Barretto) were predominantly active at ground level [cf. 58 842]and L. gomezi (Nitzu.), L. sanguinaria (Fairchild & Hertig), L. trapidoi (Fairchild & Hertig) and L. ylephiletrix (Fairchild & Hertig) in the forest canopy. Of diel biting activity at ground level, 45.9% was crepuscular, 39.0% nocturnal and 15.1% diurnal [cf. 56 95].The relatively high level of diurnal biting was due to one species, L. pessoana.In the forest canopy, 35.7% of biting activity was crepuscular, 63.7% nocturnal and only 0.6% diurnal. The seasonal man-biting activity was not completely in accord with either specific or total population trends, indicating that the biting rate at a particular time was related not only to Phlebotomid density but also to other undefined factors, including variation in the physiological state of the females.
KW - behaviour
KW - biting rates
KW - feeding behaviour
KW - Panama
KW - Leishmania
KW - Leishmania panamensis
KW - Lutzomyia
KW - Lutzomyia olmeca
KW - man
KW - Phlebotominae
KW - Psychodidae
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Leishmania
KW - Phlebotominae
KW - Psychodidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - Lutzomyia
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Central America
KW - America
KW - Developing Countries
KW - Threshold Countries
KW - Latin America
KW - behavior
KW - feeding behavior
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000653&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Quantitation of serum lipoproteins by electrophoresis on agarose gel: standardization in lipoprotein concentration units (mg/100 ml) by comparison with analytical ultracentrifugation.
AU - HULLEY, S. B.
AU - COOK, S. G.
AU - WILSON, W. S.
AU - NICHAMAN, M. Z.
AU - HATCH, F. T.
AU - LINDGREN, F. T.
JO - Journal of Lipid Research
JF - Journal of Lipid Research
Y1 - 1971///
VL - 12
IS - 4
SP - 420
EP - 433
SN - 0022-2275
AD - HULLEY, S. B.: Community Medicine Program, US Public Health Service Hospital, San Francisco, Calif. 94118.
N1 - Accession Number: 19721495093. Publication Type: Journal Article. Language: English.
KW - blood serum
KW - electrophoresis
KW - lipoproteins
KW - standardization
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Ixodes (Ixodes) nuttallianusSchulze : redescription of female, description of male, and hosts and ecology in Nepal (Acariña : Ixodidae).
AU - CLIFFORD, C. M.
AU - KEIRANS, J. E.
AU - HOOGSTRAAL, H.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1971///
VL - 8
IS - 4
SP - 439
EP - 442
SN - 0022-2585
AD - CLIFFORD, C. M.: Public Health Service, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1 - Accession Number: 19721000655. Publication Type: Journal Article. Language: English. Number of References: 4 ref.
N2 - The following is substantially the authors' abstract. Ixodes nuttallianus Schulze had previously been known only from five female specimens from two deer in China. The female is redescribed, and the male is described. This species is a member of the Eurasian group of I. ricinus (L.) and I. persulcatus Schulze. Data are presented for 110 adults in 25 collections from north-central Nepal and southern Tibet at altitudes between 2632 and 3640 m. Hosts, except for a domestic dog, were wild and domesticated Cervids and Bovids (including domestic goats, cows and cow-yak hybrids). The Nepal hosts are associated chiefly with oak and tall fir forest interspersed with rhododendrons and thick alpine scrub near alpine meadows.
KW - altitude
KW - cows
KW - ecology
KW - hybrids
KW - redescriptions
KW - taxonomy
KW - China
KW - Nepal
KW - Tibet
KW - cattle
KW - Cervidae
KW - deer
KW - goats
KW - Ixodes
KW - Ixodes persulcatus
KW - Ixodes ricinus
KW - Ixodidae
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - ungulates
KW - eukaryotes
KW - Cervidae
KW - deer
KW - Capra
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - Ixodes
KW - East Asia
KW - Asia
KW - Developing Countries
KW - South Asia
KW - Least Developed Countries
KW - South Western China
KW - China
KW - systematics
KW - Xizang
KW - Xizhang
KW - Animal Ecology (ZZ332)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000655&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Speed of action of an Aedes aegypti ovicide.
AU - WILTON, D. P.
AU - HOPKINS, S. R.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 4
SP - 479
EP - 481
AD - WILTON, D. P.: Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001174. Publication Type: Journal Article. Language: English. Number of References: 3 ref.
N2 - The following is based largely on the authors' summary. When mature eggs (3-10 days old) of Aedes aegypti (L.) that had been laid in the laboratory on aluminium panels were sprayed with an aqueous mixture of 0.2% decanol, 0.2% benzylpyridine and 1% diethanolamine [cf. RAE B 58 1072, etc.] and subsequently kept at 80°F and 85% R.H., pronounced rupture and collapse of the eggs had occurred after 5 h and only 1% had hatched. When immature eggs (24-36 h old) were treated in the same way but kept at 80°F and 100% R.H., none hatched if the mixture remained on them for at least 2 h. The mode of action of the mixture, therefore, did not involve a hatching stimulus. Collapse of the shell did not occur among immature eggs kept for the entire post-treatment period at 100% R.H. but was observed among those that were transferred to 85% R.H. for the last 24 h of the period; there was little difference in mortality between the two groups of eggs.
KW - effects
KW - mode of action
KW - mortality
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - death rate
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001174&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Production of Aedes mediovittatus (Coquillett) and its response to temperature and food conditions.
AU - FAY, R. W.
AU - KEIRANS, J. E.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 4
SP - 488
EP - 491
AD - FAY, R. W.: Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001176. Publication Type: Journal Article. Language: English. Number of References: 8 ref.
N2 - A colony of Aedes mediovittatus (Coq.) was established in the laboratory in Georgia in March 1967 from eggs collected, in association with those of A. aegypti (L.), in artificial oviposition sites [cf. RAE B 58 1202, etc.] in Puerto Rico. The adults of A. mediovittatus, which were kept in a 22-in. cubical cage, fed readily on man. Subsequently, they were give access to rabbits for a period of 2 h on 3 days a week. Eggs were laid above the water line on strips of grey or tan velour paper clipped inside a glass jar (1 US pt) coated black on the outside and containing a little water. The strips were removed daily and placed in a tightly-closed plastic container without any free water. After 7-14 days of conditioning, the eggs hatched readily when placed in a day-old preparation of brewers' yeast and water. The larvae, which were kept in enamel pans (2×9×13 in.) at 300 per litre of tap water, were provided with 0.15 and 0.30 mg ground laboratory food per larva on days 1 and 2, respectively, and with 0.60 mg daily thereafter. In water at a temperature of 25-27°C, larvae completed development in the first instar on days 2-3, in the second instar on days 3-6, in the third instar on days 4-7 and in the fourth instar on days 6-12. The first pupae appeared on day 8, and the adult males emerged 2-3 days after pupation and the females 3-4 days after pupation. The rate of survival to the adult stage was 78-85%. When less than one day old, 550 males and 300 females were placed in a cage and 50 females were removed daily for 4 days. Each group of females was given access to a rabbit on 4 successive days. Almost all the females took a blood-meal at 48 h, and eggs were laid 4-10 days after the first meal. An average of 2200 eggs was obtained each day from a colony to which 50 males and 50 females were added daily. Studies of the effects of temperature and amount of food [cf. 58 773] on the development of larvae of A. mediovittatus and A. aegypti showed that at all comparable food regimens and temperature conditions, larval development usually took longer in A. mediovittatus than in A. aegypti. The period to the completion of pupation was equal in the two species only at a constant temperature of 80°F or a fluctuating temperature of 70-90°F and full food ration. The development of A. mediovittatus was retarded at a constant temperature of 60°F and a fluctuating one of 50-70°F. This may explain the failure of the species to become established in the southern United States. In experiments with mixed caged populations of adults of A. mediovittatus and A. aegypti, females of the former mated with males of the latter but did not lay eggs or subsequently mate with males of their own species. However, females of A. aegypti that had been caged with males of A. mediovittatus subsequently mated with males of their own species and laid many viable eggs.
KW - animal behaviour
KW - behaviour
KW - blood-meals
KW - breeding places
KW - developmental stages
KW - larvae
KW - oviposition
KW - regimens
KW - survival
KW - temperature
KW - Georgia
KW - Puerto Rico
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Aedes mediovittatus
KW - Culicidae
KW - man
KW - rabbits
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Leporidae
KW - Lagomorpha
KW - small mammals
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Southeastern States of USA
KW - Greater Antilles
KW - Caribbean
KW - Developing Countries
KW - Latin America
KW - animal behavior
KW - behavior
KW - breeding habitats
KW - breeding sites
KW - growth phase
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus mediovittatus
KW - Porto Rico
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
KW - Animal Ecology (ZZ332)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001176&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Effect of dietary monosodium L-glutamate on some brain and liver metabolites in rats.
AU - PROSKY, L.
AU - O'DELL, R. G.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1971///
VL - 138
IS - 2
SP - 517
EP - 522
SN - 0037-9727
AD - PROSKY, L.: Division of Nutrition, Food and Drug Administration, US Dept. Health, Education and Welfare, Washington, D.C. 20204.
N1 - Accession Number: 19721406004. Publication Type: Journal Article. Language: English. Registry Number: 56-86-0, 56-85-9.
N2 - Weanling male albino rats in 5 groups of 10 were given, to appetite for 16 weeks, diets of Purina Laboratory Chow alone or with 1, 5, 10 or 20% monosodium L-glutamate (MSG). The rats were then killed and whole brain and liver were removed for estimation of some metabolites of MSG. In brain, y-aminobutyric acid (GABA) in rats given the 1% MSG diet was decreased by 17% from control values; a maximum decrease of 20% was observed in rats given 20% MSG. Hyperirritability was observed in all groups given the MSG supplements. Succinate in brain increased as dietary MSG increased; in the rats given 20% MSG succinate was increased 20% above control values. No changes were noted in brain weight, protein or DNA or in glutamine and aspartate; despite the high MSG intakes, brain glutamate remained relatively constant, as did glutamic acid decarboxylase. In liver, no effect of dietary MSG on protein, RNA-P, DNA-P, glutamate, lactate, malate or α-glycerophosphate was noted; aspartate increased significantly. It is suggested that the hyperirritability may be related to brain GABA levels.-G. F. G.
KW - animal models
KW - appetite
KW - brain
KW - diets
KW - DNA
KW - estimation
KW - glutamic acid
KW - glutamine
KW - liver
KW - metabolites
KW - supplements
KW - techniques
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - cerebrum
KW - deoxyribonucleic acid
KW - Animal Models of Human Nutrition (VV140)
KW - Techniques and Methodology (ZZ900)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721406004&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Studies with juvenile hormone-type compounds against mosquito larvae.
AU - JAKOB, W. L.
AU - SCHOOF, H. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 4
SP - 540
EP - 543
AD - JAKOB, W. L.: Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001184. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 50-29-3, 60-57-1, 7732-18-5.
N2 - In laboratory tests in the United States with 12 synthetic compounds with juvenile-hormone-like activity, third-instar mosquito larvae were introduced into beakers of well water that had been treated not less than 30 min earlier with acetone solutions of the compounds. A susceptible strain of Anopheles stephensi List., a dieldrin-resistant strain of A. albimanus Wied., a DDT-resistant strain of Aedes aegypti (L.) and a strain of Culex pipiens fatigans [Culex quinquefasciatus] Wied. (pipiens quinquefasciatus auct.) resistant to DDT and dieldrin were used. Mortality was determined from the proportion of treated larvae that failed to give rise to apparently normal adults. Five compounds caused at least 95% reductions in adult emergence at concentrations of 0.1 p.p.m. or less. At this concentration, (+)-1-(3', 7'-dimethyl-6', 7'-epoxyoctanyl)-3, 4-methylenedioxypheriyl ether was effective against all four species, 1-(3', 7'-dimethyl-7'-ethoxyoct-2'-enyl)-3, 4-methylenedioxyphenyl ether was effective against C. p. fatigans, 1-(3', 7'-dimethyl-6', 7'-epoxyoct-2-enyloxy)-3, 4-methylenedioxybenzene was effective against C. p. fatigans and Anopheles albimanus, 1-(3'-methyl-7'ethyl-6', 7'-epoxynon-2'-enyl)-3, 4-methylenedioxyphenyl ether was effective against A. stephensi and ethyl 11-ethoxy-3, 7, 11-trimethyldodec-2-(trans)-enoate was effective against A. albimanus; 1-(3'-methyl-7'-ethyl-6', 7'-epoxynon-2'-enyl)-3, 4-methylene-dioxyphenyl ether was effective against Aedes aegypti at 0.05 p.p.m. and against C. p. fatigans at 0.0025 p.p.m., and ethyl 11-ethoxy-3, 7, 11-trimethyldodec-2-(trans)-enoate was effective against C. p. fatigans at 0.05 p.p.m. C. p. fatigans was generally the most susceptible species. With many of the compounds, treated larvae gave rise to pupae showing anomalies, particularly in Anopheles albimanus.
KW - DDT
KW - dieldrin
KW - larvae
KW - mortality
KW - pesticide resistance
KW - pesticides
KW - water
KW - wells
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles stephensi
KW - Culex
KW - Culex pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culex
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - death rate
KW - dicophane
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001184&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Introductory survey of adult mosquitoes in the YukonKuskokwim Delta of Alaska.
AU - TANIMOTO, R. M.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 4
SP - 544
EP - 551
AD - TANIMOTO, R. M.: Office of Environmental Health, U.S. Public Health Service, Alaska Native Hospital, Bethel, Alaska 99559, USA.
N1 - Accession Number: 19721001185. Publication Type: Journal Article. Language: English. Number of References: 7 ref.
N2 - The following is based largely on the author's abstract. During rapid field surveys in the Yukon-Kuskokwim Delta of Alaska in May-October 1970, adults (mainly females) of Aedes cinereus Mg., A. communis (Deg.), A. excrucians (Wlk.), A. hexodontus Dyar, A. impiger (Wlk.), A. intrudens Dyar, A. nigripes (Zett.), A. punctor (Kby.), Culiseta alaskaensis (Ludl.), another (possibly undescribed) species of Aedes, and A. Stimulans (Wlk.) or A. fitchii (Felt & Young) or both were collected. The distribution of the mosquitos was related to the three typical types of tundra in the area, the coastal desert tundra, the grass tundra (of flat lowland basins and upland rolling hills and bogs) and the bush tundra (of sheltered up-river valleys). In the Delta, the biting period of mosquitos lasted from mid-May to late September. The seasonal succession of species in Bethel was C. alaskaensis, A. impiger and A. nigripes, A. hexodontus, A. punctor, a species that was probably A. intrudens, A. excrucians, and A. cinereus.
KW - coastal areas
KW - distribution
KW - surveys
KW - Alaska
KW - USA
KW - Aedes
KW - Aedes cinereus
KW - Aedes excrucians
KW - Culicidae
KW - Culiseta
KW - Culiseta alaskaensis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Culiseta
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus excrucians
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001185&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - California group arboviruses : isolations from mosquitoes in North America.
AU - SUDIA, W. D.
AU - NEWHOUSE, V. F.
AU - CALISHER, C. H.
AU - CHAMBERLAIN, R. W.
JO - Mosquito News
JF - Mosquito News
Y1 - 1971///
VL - 31
IS - 4
SP - 576
EP - 600
AD - SUDIA, W. D.: Center for Disease Control Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19721001190. Publication Type: Journal Article. Language: English. Number of References: 83 ref.
N2 - In the natural transmission cycles of arboviruses of the California group, small mammals are the primary vertebrate hosts and mosquitos, mainly species of Aedes, are the arthropod vectors; infection in man is incidental. This paper comprises a detailed report of all confirmed or suspected cases of California virus infections in man in the United States and of all known isolations of viruses of the group from mosquitos in the United States and Canada in 1943-70. Of a total of 1353 isolations of viruses of the group, 425 were from A. atlanticus D. & K. or A. tormentor D. & K., 209 from A. dorsalis (Mg.), 153 from A. infirmatus D. & K., 125 from A. trivittatus (Coq.) and 57 from Culiseta inornata (Will.). San Angelo virus has been isolated in Texas from Psorophora confinnis (Lynch Arrib.), Anopheles pseudopunctipennis pseudopunctipennis Theo. and a mixed pool of Aedes atlanticus and A. infirmatus. South River virus has been isolated in New Jersey from A. sollicitans (Wlk.), Anopheles crucians Wied. and C. melanura (Coq.).
KW - arboviruses
KW - hosts
KW - infections
KW - small mammals
KW - vectors
KW - viral diseases
KW - America
KW - California
KW - Canada
KW - New Jersey
KW - North America
KW - Texas
KW - USA
KW - Aedes
KW - Aedes atlanticus
KW - Anopheles
KW - Anopheles crucians
KW - Anopheles pseudopunctipennis
KW - Culicidae
KW - Culiseta
KW - Culiseta inornata
KW - man
KW - Psorophora
KW - Psorophora confinnis
KW - vertebrates
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culiseta
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Psorophora
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Commonwealth of Nations
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Great Plains States of USA
KW - Gulf States of USA
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus atlanticus
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001190&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The effect of 28-day pesticide feeding on serum and tissue enzyme activities of rats fed diets of varying casein content.
AU - CASTERLINE, J. L.
AU - Jr.
AU - WILLIAMS, C. H.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1971///
VL - 18
IS - 3
SP - 607
EP - 618
SN - 0041-008X
AD - CASTERLINE, J. L.: Division of Pesticide Chemistry and Toxicology, Food and Drug Administration, Dept. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721493775. Publication Type: Journal Article. Language: English. Registry Number: 9000-81-1, 9001-45-0.
N2 - Female and male rats were given diets containing 19, 8 or 3% casein with no pesticide or with pesticides at different concentrations for 28 days. In rats of both sexes given diets with no pesticide, the liver triacetinesterase (AliE) activity was related to the amount of casein eaten. The serum cholinesterase (ChE) activity of females also decreased with decreasing casein but in males was reduced only in those given 8% casein. Serum AliE activity was most with 8 and 3% casein. ChE activity in brain, β-glucuronidase (βGlu) activity in serum and aniline hydroxylase activity in liver were the same at all casein levels. The activity of p-nitroreductase was reduced with low casein. In those given pesticide, chlordane-induced increases in liver AliE, aniline hydroxylase and pnitroreductase activities were dependent on pesticide dose. Increases in serum AliE activity were dependent on both pesticide dose and casein intake. Chlordane reduced serum β-Glu more at 8 than at the 19% casein. Parathion-induced inhibition of serum ChE, serum and liver AliE and brain ChE increased with increasing dose and with decreasing casein. Parathion increased serum β-Glu activity to the same degree at all casein levels. Banol-induced inhibition of ChE in the serum was pronounced with low casein. The increase in serum AliE by Banol followed the decrease in casein, inhibition of liver AliE was independent of casein intake and was dose-dependent. Banol did not affect β-Glu.
KW - acetylcholinesterase
KW - animal models
KW - beta-glucuronidase
KW - blood serum
KW - brain
KW - casein
KW - diets
KW - enzyme activity
KW - enzymes
KW - feeding
KW - inhibition
KW - liver
KW - pesticides
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - cerebrum
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Clinical and epidemiological observations on an outbreak of plague in Nepal.
AU - LAFORCE, F. M.
AU - ACHARYA, I. L.
AU - STOTT, G.
AU - BRACHMAN, P. S.
AU - KAUFMAN, A. F.
AU - CLAPP, R. F.
AU - SHAH, N. K.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1971///
VL - 45
IS - 6
SP - 693
EP - 706
SN - 0042-9686
AD - LAFORCE, F. M.: Center for Disease Control, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19721002169. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 24 ref. Registry Number: 50-29-3.
N2 - An outbreak of plague occurred at Nawra, Bajhang District, western Nepal, 26 cases being recorded in September-November 1967. Clinical and epidemiological evidence suggested that the disease was introduced into the village by a person infected in a nearby sylvatic focus and that its subsequent spread was partly due to man-to-man transmission by infected fleas, presumably Pulex irritans L. which was found in the village on a dog. Antibodies to plague were found in 3 of 4 dogs examined. Control measures included spraying the interiors of all houses with 5 % phenol on three successive days and, later, with DDT. Plague has not previously been reported from Nepal, and the focus now identified probably represents the most southerly extension so far recorded of the central Asian plague area.
KW - antibodies
KW - control
KW - control methods
KW - DDT
KW - disease transmission
KW - dwellings
KW - epidemiology
KW - outbreaks
KW - pesticides
KW - plague
KW - spraying
KW - villages
KW - Nepal
KW - dogs
KW - Pulex
KW - Pulex irritans
KW - Siphonaptera
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Pulicidae
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Pulex
KW - South Asia
KW - Asia
KW - Least Developed Countries
KW - Developing Countries
KW - dicophane
KW - human flea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Gross anatomical, histological, and cytological aspects of ovarian development in Dermacentor andersoni Stiles (Acari : Ixodidae).
AU - BRINTON, L. P.
AU - OLIVER, J. H.
AU - Jr.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1971///
VL - 57
IS - 4
SP - 708
EP - 719
SN - 0022-3395
AD - BRINTON, L. P.: Public Health Service, Hamilton, Montana 59840, USA.
N1 - Accession Number: 19721000141. Publication Type: Journal Article. Language: English. Number of References: 27 ref.
KW - histology
KW - ovarian development
KW - Acari
KW - Dermacentor
KW - Dermacentor andersoni
KW - Ixodidae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Dermacentor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000141&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Fine structure of oogonial and oocyte development in Dermacentor andersoni Stiles (Acari : Ixodidae).
AU - BRINTON, L. P.
AU - OLIVER, J. H.
AU - Jr.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1971///
VL - 57
IS - 4
SP - 720
EP - 747
SN - 0022-3395
AD - BRINTON, L. P.: Public Health Service, Hamilton, Montana 59840, USA.
N1 - Accession Number: 19721000142. Publication Type: Journal Article. Language: English. Number of References: 2 1/2 pp. ref.
KW - ultrastructure
KW - Acari
KW - Dermacentor
KW - Dermacentor andersoni
KW - Ixodidae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Dermacentor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000142&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Tissue-residue depletion of sulfa-thiazole in swine.
AU - RIGHTER, H. F.
AU - WORTHINGTON, J. M.
AU - MERCER, H. D.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1971///
VL - 33
IS - 4
SP - 797
EP - 798
SN - 0021-8812
AD - RIGHTER, H. F.: Division of Veterinary Research, Bureau of Veterinary Medicine, Food and Drug Administration, Beltsville, Md. 20705, USA.
N1 - Accession Number: 19721407399. Publication Type: Journal Article. Language: English.
N2 - Pigs of about 50 kg were given sodium sulpha-thiazole 330 mg/kg bodyweight daily for 3 days by mouth. Residues of the drug were estimated 12 h and 3, 5, 7, 10 and 12 days after the last dose, in brain, muscle, liver, kidney, fat and urine. On the day of the last dose urine had 1405 g/g, this fell to 87.3 µg on day 3 and 3 to 12 µg were found on day 10. In tissues values were highest in kidney, then in liver, fat and muscle. In the first 3 they fell rapidly and none was found after 10 days. In muscle the initial value was only 5 µg/g and this fell also but on day 7 there was an unexplained rise. In 2 pigs not given the drug there were traces of it in liver, kidney, muscle, fat and urine.-T. D. B.
KW - body weight
KW - brain
KW - depletion
KW - liver
KW - muscles
KW - oral administration
KW - residues
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - ungulates
KW - eukaryotes
KW - cerebrum
KW - hogs
KW - swine
KW - Animal Nutrition (General) (LL500)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Aflatoxin excretion in wethers.
AU - STOLOFF, L.
AU - DANTZMAN, J.
AU - ARMBRECHT, B. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1971///
VL - 9
IS - 6
SP - 839
EP - 846
AD - STOLOFF, L.: Food and Drug Administration, Dept. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721407609. Publication Type: Journal Article. Language: English. Language of Summary: French;German. Registry Number: 1162-65-8, 6795-23-9.
N2 - A total of 10 wethers were given near lethal doses of aflatoxin B1 from 1.28 to 4.00mg/kg bodyweight once, or on 2 consecutive days, or got smaller doses, 0 14 to 0.59 mg on 2 consecutive days; the smallest dose was given for 6 days. Excretion of aflatoxin M1 in urine and faeces was estimated. The excretion pattern of aflatoxin M1 in urine was related to the total amount of aflatoxin given and differed between groups. The amount of aflatoxin B1 in urine also depended on the dose. When wethers were given a second dose after 100 days on pasture without aflatoxin their pattern of excretion was different the second time. Except for wethers given most total aflatoxin or the largest number of doses ratio of aflatoxin B1 to M1 in faeces was fairly constant at 2.4: 1. Total excretion of the 2 toxins in urine and faeces, in relation to the dose of aflatoxin B1 was constant also. The results are discussed in relation to the excretion patterns and presence of aflatoxin M1 in milk of cows and ewes.-T. D. B.
KW - aflatoxins
KW - body weight
KW - cows
KW - ewes
KW - excretion
KW - faeces
KW - milk
KW - mycotoxins
KW - pastures
KW - urine
KW - cattle
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - ungulates
KW - eukaryotes
KW - Ovis
KW - aflatoxin B1
KW - aflatoxin M1
KW - feces
KW - fungal toxins
KW - grazing lands
KW - Weeds and Noxious Plants (FF500)
KW - Grasslands and Rangelands (PP350)
KW - Forage and Feed Products (Non-human) (RR000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721407609&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - An assessment of some public health problems resulting from feeding poultry litter to animals. Microbiological and chemical parameters.
AU - MESSER, J. W.
AU - LOVETT, J.
AU - MURTHY, G. K.
AU - WEHBY, A. J.
AU - SCHAFER, M. L.
AU - READ, R. B.
AU - Jr.
JO - Poultry Science
JF - Poultry Science
Y1 - 1971///
VL - 50
IS - 3
SP - 874
EP - 881
SN - 0032-5791
AD - MESSER, J. W.: US Dept. Health, Education and Welfare, Public Health Service, Food and Drug Administration, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19721494018. Publication Type: Journal Article. Language: English.
KW - feeding
KW - health
KW - litter
KW - poultry
KW - public health
KW - domesticated birds
KW - Health Services (UU350)
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DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Cadmium, copper, iron, lead, manganese, and zinc in evaporated milk, infant products, and human milk.
AU - MURTHY, G. K.
AU - RHEA, U. S.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 1971///
VL - 54
IS - 7
SP - 1001
EP - 1005
SN - 0022-0302
AD - MURTHY, G. K.: US Dept. Health, Education and Welfare, Food and Drug Administration, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19721492857. Publication Type: Journal Article. Language: English. Registry Number: 7440-43-9, 7440-50-8, 7439-89-6, 7439-96-5, 7440-66-6.
N2 - Infant formula foods, such as evaporated milk, modified milk, and formulas containing lamb meat and soya flour, were collected quarterly from the Cincinnati, Ohio, market. Human milk from 13 mothers living in the Cincinnati area was collected during April and May 1968. Cd, Cu, Fe, Pb, Mn and Zn were estimated by atomic absorption spectrophotometry. Average values found for 6 elements were: Cd 0.020 to 0.042; Cu 0.024 to 1.49; Fe 0.84 to 19.1; Pb 0.012 to 0.87; Mn 0.12 to 2.68; and Zn 1.34 to 8.60 ppm. Human milk and formulas containing milk base had least Cd, Cu, Mn, and Pb; evaporated milk had most Pb. Formulas containing soya flour and lamb meat products were rich in trace elements.
KW - analysis
KW - cadmium
KW - copper
KW - estimation
KW - evaporated milk
KW - flours
KW - foods
KW - human milk
KW - infant formulae
KW - iron
KW - manganese
KW - meat products
KW - milk products
KW - minerals
KW - spectrophotometry
KW - techniques
KW - trace elements
KW - zinc
KW - Ohio
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Corn Belt States of USA
KW - breast milk
KW - dairy products
KW - infant formula
KW - infant formulas
KW - lamb meat
KW - microelements
KW - Mn
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721492857&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Fine structure of normal hemocytes in Dermacentor andersoniStiles (Acari : Ixodidae).
AU - BRINTON, L. P.
AU - BURGDORFER, W.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1971///
VL - 57
IS - 5
SP - 1110
EP - 1127
SN - 0022-3395
AD - BRINTON, L. P.: Public Health Service, Rocky Mountain Laboratory, Hamilton, Montana 59840, USA.
N1 - Accession Number: 19721000699. Publication Type: Journal Article. Language: English. Number of References: 27 ref.
KW - haemocytes
KW - ultrastructure
KW - Acari
KW - Dermacentor
KW - Ixodidae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - hemocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721000699&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Analysis of nitrite- and/or nitrate-processed meats for N-nitrosodimethylamine.
AU - FAZIO, T.
AU - WHITE, R. H.
AU - HOWARD, J. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 5
SP - 1157
EP - 1159
AD - FAZIO, T.: Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721492895. Publication Type: Journal Article. Language: English.
N2 - The presence of the carcinogen N-nitrosodimethyl-amine detected in a sample of ham, 5 x 10-9, by gas-liquid chromatography was confirmed by mass spectrometry. Amounts in other 50 samples of meat products including raw beef were too low to be similarly confirmed. For previous work see Abst. 7363, Vol. 41.-A. H.
KW - analysis
KW - analytical methods
KW - chromatography
KW - mass spectrometry
KW - meat products
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721492895&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Distribution of chick edema factors in chick tissues.
AU - FIRESTONE, D.
AU - FLICK, D. F.
AU - RESS, J.
AU - HIGGINBOTHAM, G. R.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1971///
VL - 54
IS - 6
SP - 1293
EP - 1298
AD - FIRESTONE, D.: Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721407607. Publication Type: Journal Article. Language: English.
N2 - Day-old cockerels were given for 21 days rations containing 3% toxic fat or its equivalent of un-saponifiable toxic fraction, 0.3%. The toxic fat contained di-, tri-, tetra-, penta-, hexa-, hepta- and octachlorobenzo-p-dioxin, 1.4, 0.1, 4.3, 0.5, 1.5, 1.6 and 0.5 mg/kg, respectively. Of the higher chlorodioxins, hexa- and higher, in feed, 92% was excreted in faeces and excretion was greater the higher the degree of chlorination. Liver, bone and skin contained most higher chlorodioxins as a percentage of total in tissue; skeletal muscle from chicks given the unsaponifiable fraction had 1% A. H. See also Absts. 5313, 5511, 6678, 7217, 7372, 7545-6, 7557, 7561.
KW - chicks
KW - cocks
KW - excretion
KW - faeces
KW - liver
KW - muscles
KW - poultry
KW - skeletal muscle
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - poultry
KW - eukaryotes
KW - chickens
KW - cockerels
KW - domesticated birds
KW - feces
KW - Animal Nutrition (General) (LL500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721407607&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Effect of ascorbic acid on cadmium toxicity in the young coturnix.
AU - Fox, M. R. S.
AU - FRY, B. E.
AU - Jr.
AU - HARLAND, B. F.
AU - SCHERTEL, M. E.
AU - WEEKS, C. E.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1971///
VL - 101
IS - 10
SP - 1295
EP - 1305
SN - 0022-3166
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Dept. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721405604. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7, 7440-43-9, 91-53-2, 59-30-3.
N2 - Day-old coturnix (Japanese quail) were given 75 mg Cd/kg of an adequate purified diet for 2- or 4-week periods. Cadmium produced moderate growth retardation, severe anaemia, decreased ash content of the tibia and deviations from the normal concentrations of Zn, Fe, Cd, Cu and Ca in one or more of the tissues tested: erythrocytes, liver, kidney and tibia. Dietary supplements of Zn, Fe (III), Cu and L-cysteine and injected ascorbic acid produced slight to moderate protein protection against cadmium-induced anaemia, whereas Fe (II), ascorbic acid and D-isoascorbic acid had greater effects in preventing the anaemia, growth retardation, poor bone mineralization and perturbations in elemental concentrations of tissues. Cr, Co, Se, Ni, Mo and folic acid had no effects. Cd did not affect the total ascorbate content of the liver. Removal of dietary ethoxyquin did not affect the toxicity of Cd or the protective effects of ascorbic acid. Initiation of ascorbic acid feeding at 2 weeks was beneficial to birds given Cd throughout the 4-week experiment. Under the conditions of the experiments, Cd produced a functional Fe deficiency and less clear-cut effects on Zn function. It appears that a primary effect of Cd was to prevent absorption of dietary Fe (III).
KW - absorption
KW - anaemia
KW - ascorbic acid
KW - bone mineralization
KW - bones
KW - cadmium
KW - composition
KW - deficiency
KW - diets
KW - ethoxyquin
KW - feeding
KW - folic acid
KW - food supplements
KW - growth retardation
KW - hepatectomy
KW - liver
KW - poultry
KW - protection
KW - toxicity
KW - vitamin B complex
KW - Japanese quails
KW - man
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - poultry
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - anemia
KW - domesticated birds
KW - folacin
KW - folate
KW - liver removal
KW - santoquin
KW - vitamin B
KW - vitamin C
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721405604&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Responses of adult Anopheles stephensi to light of various wavelengths.
AU - Wilton, D. P.
AU - Fay, R. W.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1972///
VL - 9
IS - 4
SP - 301
EP - 304
SN - 0022-2585
AD - Wilton, D. P.: Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19720500886. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - In laboratory tests, males and females of Anopheles stephensi List. showed strong positive phototaxis in response to light of wavelengths of 290, 365 and 690 nm. BLB-type fluorescent lamps, which have a peak emission at about 360 nm, would therefore be effective attractants in light-traps for A. stephensi.
KW - insect traps
KW - mosquito nets
KW - phototaxis
KW - traps
KW - Anopheles stephensi
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - light-traps
KW - mosquitoes
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720500886&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control of the plague vector, Opisocrostis hirsutus, by treatment of prairie dog (Cynomys ludovicianus) burrows with 2% carbaryl dust.
AU - Barnes, A. M.
AU - Ogden, L. J.
AU - Campos, E. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1972///
VL - 9
IS - 4
SP - 330
EP - 333
SN - 0022-2585
AD - Barnes, A. M.: Center for Disease Control, Public Health Service, P.O. Box 551, Fort Collins, Colorado 80521, USA.
N1 - Accession Number: 19720500892. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 63-25-2. Subject Subsets: Medical & Veterinary Entomology
N2 - Observations on two colonies of prairie dogs (Cynomys ludovicianus) were made in 1969-70 in an area near Fort Collins, Colorado, where plague due to Pasteurella (Yersinia) pestis was epizootic. The plague organism was isolated from a pool of Opisocrostis hirsutus (Baker), the flea most commonly found on the prairie dogs. The burrows of the prairie dogs in one area were each treated with 85-95 g of a 2% carbaryl dust from a knapsack duster on 7th August 1969. No fleas were found in them on the following day or on subsequent occasions up to 25th September, and the prairie-dog population survived the winter and multiplied, whereas fleas increased in the burrows of the untreated area and all prairie dogs died, though there was no direct evidence that plague was the cause. O. hirsutus was numerous in untreated burrows in April 1970, but only a single example was found in one burrow in the treated area, where, after another treatment with 55-65 g 2% carbaryl dust on 8th May, no fleas were found up to the last searches at the end of July. It is concluded that the fleas and the transmission of plague were eliminated by the carbaryl treatment [cf. RAE/B 59, 1409; 60, 1141].
KW - carbaryl
KW - chemical control
KW - control
KW - insect control
KW - isolation
KW - testing
KW - Colorado
KW - USA
KW - Cynomys ludovicianus
KW - Opisocrostis
KW - Opisocrostis hirsutus
KW - Siphonaptera
KW - Yersinia pestis
KW - Cynomys
KW - Sciuridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ceratophyllidae
KW - Siphonaptera
KW - Opisocrostis
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - bacterium
KW - Opisocrostic hirsutus
KW - Pasteurella pestis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720500892&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Teratology studies on food colourings. 1. Embryotoxicity of amaranth (FD & C Red No. 2) in rats.
AU - Collins, T. F. X.
AU - McLaughlin, J.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1972///
VL - 10
IS - 5
SP - 619
EP - 624
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dept. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721404252. Publication Type: Journal Article. Language: English. Language of Summary: French; German. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 1. The red dye, amaranth (the trisodium salt of 1-(4-sulpho-1-naphthylazo)-2-naphthol-3,6-disulphonic acid; FD and C Red No. 2; 94% pure), was given by stomach tube to female Osborne-Mendel rats at 7.5, 15, 30, 100 or 200 mg/kg daily for the first 19 days of pregnancy. No adverse clinical signs were observed in any dam. One litter was aborted at the highest dose. The number of live foetuses/litter was dose-related. At 7.5 to 100 mg/kg, all deaths were classed as early deaths, but at 200 mg/kg there were late deaths and a greater number of early deaths, indicating either systemic effects or toxicity to the foetus of the compound. The number of litters with one or more and 2 or more resorptions and the number of litters totally resorbed increased with increasing doses of amaranth. No effect was seen in the mean weight of the foetuses. No gross terata appeared and neither skeletal nor soft tissue abnormalities were seen in the experimental rats.
KW - malformations
KW - toxicity
KW - Amaranthus
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Amaranthaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - congenital
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19721404252&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Major fecal metabolite of dieldrin in rat. Structure and chemistry.
AU - McKinney, J. D.
AU - Matthews, H. B.
AU - Fishbein, L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1972///
VL - 20
IS - 3
SP - 597
EP - 602
SN - 0021-8561
AD - McKinney, J. D.: National Inst. Environmental Health Sciences, Public Health Service, Triangle Park, N.C. 27709, USA.
N1 - Accession Number: 19721400177. Publication Type: Journal Article. Language: English. Registry Number: 60-57-1. Subject Subsets: Animal Nutrition; Human Nutrition; Agricultural Entomology
KW - agricultural entomology
KW - dieldrin
KW - insecticides
KW - metabolism
KW - nontarget effects
KW - pesticides
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19721400177&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Proceedings of the Inter-American Malaria Research Symposium, San Salvador, El Salvador, November 1-14, 1971.
A2 - Scholtens, R. G.
A2 - Najera, J. A.
T2 - American Journal of Tropical Medicine and Hygiene
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1972///
VL - 21
IS - 5 part 2
SP - 611
EP - 850
SN - 0002-9637
AD - Center for Disease Control, Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 19720502191. Publication Type: Conference proceedings. Language: English. Number of References: Many ref. Subject Subsets: Medical & Veterinary Entomology; Helminthology
N2 - The papers read at this symposium that are concerned with Anopheline vectors are:.
KW - helminths
KW - mosquito nets
KW - parasites
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Inter-American Malaria Research Symposium
KW - mosquitoes
KW - parasitic worms
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
KW - Medical and Veterinary Helminthology Records (TT100) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720502191&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent advances in insecticides for malaria programs.
AU - Schoof, H. F.
AU - Taylor, R. T.
A2 - Scholtens, R. G.
A2 - Najera, J. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1972///
VL - 21
SP - 807
EP - 812
SN - 0002-9637
AD - Schoof, H. F.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19720502204. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 122-14-5, 121-75-5, 114-26-1, 3383-96-8. Subject Subsets: Medical & Veterinary Entomology
N2 - The results of tests of insecticides to replace DDT in malaria eradication programmes are summarised. Malathion, propoxur and fenitrothion are the compounds that should receive initial consideration for use as deposits against mosquitos resistant to DDT. Malathion is the compound of choice for use in aerosols against adult mosquitos, and Abate (O,O,O',O'-tetramethyl O,O'-thiodi-p-phenylene diphosphorothioate) is the compound of choice for use as a larvicide. In future, all three types of application may have to be employed together in order to control mosquitos that transmit malaria through outdoor biting.
KW - control
KW - fenitrothion
KW - malathion
KW - mosquito nets
KW - organophosphorus compounds
KW - propoxur
KW - temephos
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - diphosphorothioate
KW - mosquitoes
KW - organic phosphorus compounds
KW - organophosphates
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720502204&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emerging foodborne diseases. I. Their surveillance and epidemiology. II. Factors that contribute to outbreaks and their control.
AU - Bryan, F. L.
JO - Journal of Milk and Food Technology
JF - Journal of Milk and Food Technology
Y1 - 1972///
VL - 35
IS - 10; 11
SP - 618
EP - 638
AD - Bryan, F. L.: Public Health Service, Dept. of Health, Education & Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19720401640. Publication Type: Journal Article. Language: English. Number of References: 49 + 17 ref. Subject Subsets: Human Nutrition; Dairy Science; Veterinary Science
KW - control
KW - epidemiology
KW - food poisoning
KW - Milkborne diseases
KW - reviews
KW - zoonoses
KW - milk-borne diseases
KW - surveillence
KW - zoonotic infections
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720401640&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxic response of rats to cyclamates in chow and semisynthetic diets.
AU - Friedman, L.
AU - Richardson, H. L.
AU - Richardson, M. E.
AU - Lethco, E. J.
AU - Wallace, W. C.
AU - Sauro, F. M.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1972///
VL - 49
IS - 3
SP - 751
EP - 764
SN - 0027-8874
AD - Friedman, L.: Division of Toxicology, Bureau of Foods, Food and Drug Administration, US Dep. Health, Education and Welfare, Washington, D.C. 20204.
N1 - Accession Number: 19731409546. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Holtzman rats in groups of about 20 were given to appetite for 75 weeks a semisynthetic diet with casein 10 or 20% and without or with calcium cyclamate 1 or 2%. In a second experiment Osborne-Mendel rats in groups of 28, controls, and 14 were given to appetite for 101 weeks a stock diet without or with calcium or sodium cyclamate 0.4, 2 or 10%. Growth of the rats on the semisynthetic diet with cyclamate was reduced to week 25, significantly so in those given 2%, with both amounts of protein. Faeces were softer than normal. Calcium cyclamate did not seem to cause any cytogenic damage. Controls had normal bladders and kidneys but those given cyclamates had abnormally opaque or greyish bladder walls and stones in the bladder or kidneys. Of all the rats given cyclamate with the semisynthetic diet 25.8% had abnormalities of the bladder and 32.3% had abnormalities in one organ or another. Half of the rats given the stock diet with cyclamates had thickened or oedematous bladder walls and some had papillomata of the bladder. Nephrocalcinosis and calyceal polyposis were the most frequent lesions in the kidneys. Transitional cell carcinoma was present in the bladder of 3 of the 23 rats given the stock diet with calcium cyclamate; 2 of those rats had been on 0.4% calcium cyclamate. Only about a quarter of the rats given sodium cyclamate and less than 10% of those given calcium cyclamate showed no unusual lesion in the urinary tract.
KW - cyclamates
KW - substitutes
KW - sugars
KW - toxicity
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731409546&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxigenic fungi from poultry feed and litter.
AU - Lovett, J.
JO - Poultry Science
JF - Poultry Science
Y1 - 1972///
VL - 51
IS - 1
SP - 309
EP - 313
SN - 0032-5791
AD - Lovett, J.: US Dept. Health, Education, and Welfare, Public Health Service, Food and Drug Administration, Division of Microbiology, Cincinnati, Ohio 45226.
N1 - Accession Number: 19721400223. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology; Veterinary Science
N2 - Toxin production was studied in fungi isolated from feed and litter of 2 Ohio poultry farms. Fourteen-day-slant cultures were used to inoculate neopeptone dextrose, Czapek-Dox and Mycological broth media. Four-day chick embryos were inoculated with 0.2 ml culture filtrate by the air cell. Embryo death at 9 days was used as the toxicity indicator. Fungi which produced toxin in at least one medium were Aspergillus chevalieri, (one), A. fumigatus (one), A. terreus (two), Penicillium cyclopium (two), and one each of Fusarium and Scopulariopsis sp. Of those isolates studied 13% produced toxin.
KW - chick embryos
KW - feeds
KW - foods
KW - litter
KW - Mycotoxins
KW - poisoning
KW - poisonous fungi
KW - poultry
KW - toxicity
KW - USA
KW - Aspergillus
KW - Aspergillus fumigatus
KW - Aspergillus terreus
KW - Eurotium intermedium
KW - fowls
KW - fungi
KW - Fusarium
KW - Penicillium
KW - PENICILLIUM AURANTIOGRISEUM
KW - Scopulariopsis
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Aspergillus
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Penicillium
KW - Microascaceae
KW - Microascales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Eurotium
KW - Aspergillus chevalieri
KW - Aspergillus chevalieri on foods
KW - Aspergillus chevalieri on litter
KW - Aspergillus chevalieri poisoning fowl embryo
KW - Aspergillus fumigatus poisoning fowl embryo
KW - Aspergillus terreus on litter
KW - Aspergillus terreus poisoning fowl embryo
KW - chickens
KW - disorders
KW - domesticated birds
KW - feeding stuffs
KW - fungal toxins
KW - fungi in feed
KW - fungus
KW - Fusarium a a on foods
KW - Fusarium a a on litter
KW - Fusarium a a poisoning fowl embryo
KW - Hyphomycetes
KW - Penicillium cyclopium
KW - Penicillium cyclopium on litter
KW - Penicillium cyclopium poisoning fowl embryo
KW - Penicillium patulum
KW - Penicillium patulum on foods
KW - Penicillium patulum on litter
KW - Penicillium patulum poisoning fowl embryo
KW - poisonous mushrooms
KW - Scopulariopsis a a on foods
KW - Scopulariopsis a a on litter
KW - Scopulariopsis a a poisoning fowl embryo
KW - toxicosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19721400223&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of the Food and Drug Administration in the nutritional quality of foods.
AU - Forbes, A. L.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972///
VL - 62
IS - 9
SP - 1207
EP - 1209
SN - 0090-0036
AD - Forbes, A. L.: Division of Nutrition, Bureau of Foods, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 19731406210. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The function of the Food and Drug Administration (FDA) of the United States is discussed. The scope of activities of the FDA is expanding because of the following developments: preparation of about 55% of meals in the United States outside the home; a significant incidence of malnutrition; food faddism and the use of very large, sometimes, toxic, doses of some nutrients, e.g., vitamins A and E and ascorbic acid. To meet those problems, some FDA activities are being strengthened or initiated. Nutritional guidelines are being established for convenience foods, snack foods and meal replacements. Food products are being labelled in different ways and the results are being evaluated to discover the most effective form in which nutritional information can be given. In experimental labelling of fats their sources and some of their chemical characteristics, e.g. degree of saturation, are given. The labelling of table salt to encourage consumption of iodised salt is being considered. Changes in the standards for enriched wheat flour, bread, buns and rolls, with particular reference to Fe, are being considered, and studies are being made of the physiological effects of the larger amounts of Fe that have been proposed. A new regulation requires Fe 1 mg/100 kcal (419 kJ) in infant feeds. A proposed regulation is to protect the public from trivial or toxic amounts and from gross imbalances and omissions of individual nutrients in supplements such as vitamin pills. The regulation is to be based on the recommended dietary allowances (NAR 40, 1052) rather than on a concept of minimum daily requirements.
KW - food legislation
KW - foods
KW - legislation
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731406210&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas-propelled aerosols and micronized dusts for control of insects in aircraft. 5. Effectiveness against insects of public health importance.
AU - Jakob, W. L.
AU - Maddock, D. R.
AU - Schoof, H. F.
AU - Porter, J. E.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 1972///
VL - 65
IS - 5
SP - 1454
EP - 1458
SN - 0022-0493
AD - Jakob, W. L.: Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19730503126. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Registry Number: 2104-96-3, 122-14-5, 55-38-9, 51-03-6, 114-26-1, 10453-86-8, 22248-79-9, 961-11-5, 2921-88-2. Subject Subsets: Medical & Veterinary Entomology
N2 - This fifth report on tests of insecticides for the control of insects in aircraft [cf. preceding abstract, etc.] gives the results obtained with adults and fifth-instar nymphs of Rhodnius prolixus Stal and Triatoma infestans (Klug) and with adults of Aedes aegypti (L.), Anopheles quadrimaculatus Say, A. albimanus Wied. (the last three of which were resistant to dieldrin), Musca domestica L. (one strain of which was resistant to dieldrin and DDT, another to malathion and a third to organophosphates and carbamates) and Xenopsylla cheopis (Roths.). The fleas were confined in glass tubes, and the other insects in cartons, during tests. One aerosol (G-1729) was omitted from the tests, as were all but one of the micronised dusts containing two toxicants (Dursban (chlorpyrifos) with resmethrin) and one of those containing three (tetrachlorvinphos (Gardona) with Dursban and propoxur).Dusts containing resmethrin, either alone or in combination, were the most effective of those tested, causing 100% mortality of many species after application at 1 or 2 g/1000 ft3; all the other dusts, except that containing tetrachlorvinphos, caused 95-100% mortality of fleas and mosquitos at 2 g/1000 ft3. In tests in trailers, the resmethrin aerosol caused 100% mortality of all insects except fleas (85% of which died) after application at 30 g/1000 ft3, and was nearly as effective at 10 g/1000 ft3, but at the latter dosage in aircraft it was almost innocuous to the bugs. The standard aerosol (G-1707) was the least effective of the four tested. Only dusts containing resmethrin, Mobam (benzo[b]thien-4-yl methylcarbamate) or bromophos singly caused, at 2 g/1000 ft3, 90% mortality or more of strains of M. domestica resistant to organophosphates and carbamates. Amongst the formulations without resmethrin, a dust containing 40% Dursban and an aerosol containing 11% technical d-trans allethrin gave promising results. In general, the results with the effective formulations indicated that lower insecticide concentrations than those used in the tests or lower rates of application might be satisfactory.
KW - aircraft
KW - bromophos
KW - carbamates
KW - chemical control
KW - chlorpyrifos
KW - control
KW - fenitrothion
KW - fenthion
KW - insect control
KW - insecticides
KW - piperonyl butoxide
KW - propoxur
KW - pyrethrins
KW - resmethrin
KW - synergists
KW - testing
KW - tetrachlorvinphos
KW - Aedes aegypti
KW - Anopheles albimanus
KW - Anopheles quadrimaculatus
KW - Culicidae
KW - Diptera
KW - Hemiptera
KW - insects
KW - Musca domestica
KW - Reduviidae
KW - Rhodnius prolixus
KW - Triatoma infestans
KW - Xenopsylla cheopis
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Musca
KW - Muscidae
KW - Heteroptera
KW - Hemiptera
KW - Rhodnius
KW - Triatominae
KW - Reduviidae
KW - Triatoma
KW - Xenopsylla
KW - Pulicidae
KW - Siphonaptera
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - (+)-trans-allethrin
KW - (+)-trans-allethrine
KW - benzo[b]thien-4-yl methyl-
KW - bromofos
KW - chlorpyrifos-ethyl
KW - house fly
KW - mosquitoes
KW - Oriental rat flea
KW - piperonyl-bis(2-(2'-butoxyethoxy)ethyl)acetal
KW - pyrethrum
KW - stirofos
KW - tetra chlorvinphos
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730503126&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Migration inhibition of peripheral leucocytes in human schistosomiasis.
AU - Wolfson, R. L.
AU - Maddison, S. E.
AU - Kagan, I. G.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 1972///
VL - 109
IS - 1
SP - 123
EP - 128
AD - Wolfson, R. L.: Parasitology Section, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, US Dept. of Health, Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19720800920. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - Migration inhibition of peripheral leucocytes by extracts of Schistosoma mansoni was observed in individuals who showed delayed-type skin reactivity with the parasitic antigen. There was no correlation between the in vitro migration inhibition and immediate-type hypersensitivity, the presence of specific antibody to S. mansoni in the serum, or a non-specific serum factor. A correlation between migration inhibition of peripheral leucocytes and delayed skin reactivity was observed in individuals hypersensitive to Brucella abortus. [AS].
KW - diagnosis
KW - helminths
KW - immunology
KW - parasites
KW - man
KW - Schistosoma mansoni
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - diagnosis by migration inhibition test
KW - parasitic worms
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19720800920&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mosquito larvicide studies with Mon 585, a juvenile hormone mimic.
AU - JAKOB, W. L.
AU - SCHOOF, H. F.
JO - Mosquito News
JF - Mosquito News
Y1 - 1972///
VL - 32
IS - 1
SP - 6
EP - 10
AD - JAKOB, W. L.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001639. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 50-29-3, 60-57-1, 7732-18-5.
N2 - Third-instar larvae of Aedes aegypti (L.) (DDT-resistant), A. taeniorhynchus (Wied.) (susceptible), Culex pipiens fatigans [Culex quinquefasciatus] Wied. (pipiens quinquefasciatus auct.) (resistant to DDT and dieldrin), C. tarsalis Coq. (susceptible), Anopheles albimanus Wied. (dieldrin-resistant) and A. stephensi List. (susceptible) were exposed in the laboratory in Georgia to Mon-585 (2, 6-di-tert.-butyl-4-(a, a-dimethylbenzyl)phenol), a synthetic compound with activity similar to juvenile hormone [cf. RAE B 60 1181], The effects of the treatment were determined from the proportion of larvae that failed to give rise to apparently normal adults. A concentration of 0.25 p.p.m. in well water was required to cause at least 95% mortality of A. stephensi and Aedes aegypti exposed from the. third larval instar until adult emergence and one of 0.1 p.p.m. to be similarly effective against C. p. fatigans, C. tarsalis, A taeniorhynchus and Anopheles albimanus. Affected individuals died soon after pupation [cf. 60 1184], Mon-585 demonstrated this type of activity in laboratory tests with sewage effluent or 1 % salt water and in tests outdoors with turbid water in rusty drums. The compound was not toxic to the larvae. The compound was also found to be highly effective when larvae were exposed to relatively high concentrations for limited periods; exposure of the third-instar larvae for 2 h to a concentration of 1 p.p.m. resulted in 96 and 85% mortality of C. p. fatigans and A. albimanus, respectively, and exposure for 4 h to 0.5 p.p.m. resulted in 99 and 87% mortality. Mon-585 seems to cause an irreversible, lethal interference or disruption of a process controlling the development of larvae into pupae.
KW - DDT
KW - dieldrin
KW - effluents
KW - juvenile hormone analogues
KW - juvenile hormones
KW - larvae
KW - mortality
KW - ovicides and larvicides
KW - pesticide resistance
KW - pesticides
KW - saline water
KW - sewage
KW - sewage effluent
KW - wastes
KW - water
KW - wells
KW - Georgia
KW - USA
KW - Aedes
KW - Aedes aegypti
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles stephensi
KW - Culex
KW - Culex pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culex
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Southeastern States of USA
KW - death rate
KW - dicophane
KW - juvenile hormone analogs
KW - juvenoids
KW - mosquitoes
KW - salt water
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pollution and Degradation (PP600)
KW - Pesticide and Drug Resistance (HH410)
KW - Human Wastes and Refuse (XX300)
KW - Wastes (General) (XX000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001639&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Quantitative determination of feeding rates of Anopheles albimanus larvae.
AU - WILTON, D. P.
AU - FETZER, L. E.
AU - Jr.
AU - FAY, R. W.
JO - Mosquito News
JF - Mosquito News
Y1 - 1972///
VL - 32
IS - 1
SP - 23
EP - 27
AD - WILTON, D. P.: Biology Section, Technical Development Laboratories, Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001642. Publication Type: Journal Article. Language: English. Number of References: 8 ref.
N2 - A colorimetric method using dyed particles of food (whole-wheat flour stained with Sudan Black-B) floating on the water was developed for investigating the relation of particle size to food consumption in larvae of Anopheles albimanus Wied. [cf. RAE B 59 1411, etc.]. Large numbers of larvae can be studied at the same time. After feeding, the larvae were crushed on filter paper, the dye was extracted with acetone and the optical density of the solution was found, from which the volume of food could be calculated. Particles of size 88-105 µm were always consumed in greater amounts than smaller or larger particles. Third-instar larvae could ingest an average of about 30 µg particles of 88-105 µm in 50 min.
KW - absorbance
KW - larvae
KW - techniques
KW - Sudan
KW - Anopheles
KW - Anopheles albimanus
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - East Africa
KW - Africa South of Sahara
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - ACP Countries
KW - mosquitoes
KW - optical density
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001642&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Echinococcus vogeli sp.n. (Cestoda: Taeniidae) from the bush dog, Speothos venaticus (Lund).
AU - RAUSCH, R. L.
AU - BERNSTEIN, J. J.
JO - Zeitschrift fur Tropenmedizin und Parasitologie
JF - Zeitschrift fur Tropenmedizin und Parasitologie
Y1 - 1972///
VL - 23
IS - 1
SP - 25
EP - 34
AD - RAUSCH, R. L.: Arctic Health Research Center, US Public Health Service, Fairbanks, Alaska 99701, USA.
N1 - Accession Number: 19720804321. Publication Type: Journal Article. Language: English. Language of Summary: German.
N2 - Echinococcus vogeli n.sp. from Speothos venations in Esmeraldas Province, Ecuador, is described and illustrated. It differs from E. granulosas in having larger rostellar hooks, in the different proportions of the strobila and in the structure of the gravid uterus, from E. multilocularis in having larger rostellar hooks, in the different proportions of the strobila, position of the genital pore and greater number of testes, and from E. oligarthrus in the different proportions of the strobila, position of the genital pore and greater number of testes. M.R.N.S.
KW - new species
KW - taxonomy
KW - testes
KW - uterus
KW - Ecuador
KW - Cestoda
KW - Echinococcus
KW - Echinococcus multilocularis
KW - Eucestoda
KW - Taeniidae
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Echinococcus
KW - South America
KW - America
KW - Developing Countries
KW - Threshold Countries
KW - Andean Group
KW - Latin America
KW - Cyclophyllidea
KW - Echinococcus vogeli
KW - hooks
KW - strobila
KW - systematics
KW - testicles
KW - Taxonomy and Evolution (ZZ380)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19720804321&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Two cases of myiasis in the United States by the African tumbu fly, Cordylobia anthropophaga (Diptera, Calliphoridae).
AU - RICE, P. L.
AU - GLEASON, N.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1972///
VL - 21
IS - 1
SP - 62
EP - 65
SN - 0002-9637
AD - RICE, P. L.: Center for Disease Control. Public Health Service. Atlanta. Georgia 30333. USA.
N1 - Accession Number: 19721001195. Publication Type: Journal Article. Language: English. Number of References: 10 ref.
KW - myiasis
KW - USA
KW - Cordylobia
KW - Cordylobia anthropophaga
KW - Diptera
KW - Calliphoridae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cordylobia
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001195&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The effect of vinblastine sulphate on the incorporation of (2-14C) glycine into housefly [Musca domestica L.] DNA.
AU - MILLER, S.
AU - COLLINS, J. M.
AU - FRENKEL, L. D.
JO - Insect Biochemistry
JF - Insect Biochemistry
Y1 - 1972///
VL - 2
IS - 5
SP - 87
EP - 93
AD - MILLER, S.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Box 2167, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001396. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 865-21-4, 56-40-6, 143-67-9, 14808-79-8.
KW - glycine
KW - sulfate
KW - vinblastine
KW - Musca
KW - Musca domestica
KW - Muscidae
KW - Muscidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Musca
KW - house fly
KW - vincaleucoblastine
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001396&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Recovery of Aedes albopictus from used tires shipped to United States ports.
AU - EADS, R. B.
JO - Mosquito News
JF - Mosquito News
Y1 - 1972///
VL - 32
IS - 1
SP - 113
EP - 114
AD - EADS, R. B.: Foreign Quarantine Program, Center for Disease Control, Public Health Service, Burlingame, California 94010, USA.
N1 - Accession Number: 19721001659. Publication Type: Journal Article. Language: English. Number of References: 5 ref.
N2 - Civilian contractors buy army surplus vehicle tyres in South Vietnam and ship them to the United States for re-sale there. There is no law requiring the treatment of privately owned tyres with mosquito larvicide prior to shipment from Vietnam, and several larvae and pupae of Aedes albopictus (Skuse) were found in three such tyres (containing water) on a ship that arrived at Oakland, California, in April 1971. A. albopictus is common in Vietnam, breeding in natural and artificial containers in close association with man, and has been implicated in the transmission of dengue.
KW - dengue
KW - larvae
KW - law
KW - ovicides and larvicides
KW - pupae
KW - therapy
KW - tyres
KW - California
KW - USA
KW - Vietnam
KW - Aedes
KW - Aedes albopictus
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Indochina
KW - South East Asia
KW - Asia
KW - Developing Countries
KW - ASEAN Countries
KW - legal aspects
KW - legal principles
KW - mosquitoes
KW - therapeutics
KW - tires
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001659&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - A proposed method of search for micro-organisms pathogenic to mosquitoes.
AU - WHITWORTH, B. T.
JO - Mosquito News
JF - Mosquito News
Y1 - 1972///
VL - 32
IS - 1
SP - 118
EP - 119
AD - WHITWORTH, B. T.: U.S. Public Health Service, N.E. Atlanta, Georgia 30326, USA.
N1 - Accession Number: 19721001662. Publication Type: Journal Article. Language: English.
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001662&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Screening method for aflatoxin in corn and various corn products.
AU - DANTZMAN, J.
AU - STOLOFF, L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1972///
VL - 55
IS - 1
SP - 139
EP - 141
AD - DANTZMAN, J.: Division of Food Technology, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721407803. Publication Type: Journal Article. Language: English.
N2 - An AOAC method was abbreviated to screen samples of maize for aflatoxin. The oil residue after extracting the sample with chloroform was separated from aflatoxins by primary development of the thin-layer plate with ether; one of the usual solvents then separated aflatoxins. Sensitivity was < 5 µg aflatoxin B1/kg.-A. H.
KW - aflatoxins
KW - maize
KW - methodology
KW - mycotoxins
KW - screening
KW - techniques
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - fungal toxins
KW - methods
KW - screening tests
KW - Techniques and Methodology (ZZ900)
KW - Weeds and Noxious Plants (FF500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721407803&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Lethal effects of aqueous formulations containing fatty amines or acids against eggs and larvae of Aedes aegypti.
AU - CLINE, R. E.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 1972///
VL - 65
IS - 1
SP - 177
EP - 181
SN - 0022-0493
AD - CLINE, R. E.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Box 2167, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001365. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 124-07-2, 57-13-6.
N2 - The following is substantially the author's abstract. Various aqueous chemical formulations, some of which pose minimum hazards for higher organisms, are described for use against eggs of Aedes aegypti (L.). These chemicals seem to attack mainly those layers of the egg shell that are impermeable to water; this results in the dehydration and collapse of the egg on exposure to air [cf. RAE B 60 1174]. The effects of humidity were studied before and after treatment. Basic and acidic formulations containing both non-polar and polar compounds were found effective against both dry and moist eggs exposed to the atmosphere after treatment by dipping. The basic mixture contained a non-polar long-chain aliphatic amine [cf. 58 318] such as octylamine emulsified in an aqueous solution of a polar compound such as ethanolamine or urea, and the acidic mixture contained a non-polar fatty acid such as octanoic acid in aqueous polar mercapto acid. Non-polar compounds alone in water were toxic under special conditions. An emulsion of fatty acid in water was effective against eggs exposed to high humidity before or after treatment, and aqueous fatty amines were toxic to eggs exposed to high humidity after treatment. Fatty amines, ranging widely in chain length and polarity, were tested against both fourth-instar larvae and eggs. The relative activity against larvae corresponded roughly with ovicidal activity, but the least active of these amines against larvae, 6-amino-1-hexanpl, used at 0.6% in water with 0.1% decyl alcohol and 6% urea, was a good ovicide. It is presumably the least hazardous to higher organisms of all the ovicides tested.
KW - egg shell
KW - hazards
KW - humidity
KW - larvae
KW - octanoic acid
KW - therapy
KW - urea
KW - Aedes
KW - Aedes aegypti
KW - Culicidae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - caprylic acid
KW - mosquitoes
KW - therapeutics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001365&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Human plasma iron responses following test doses of iron from known sources.
AU - PLA, G. W.
AU - FRITZ, J. C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1972///
VL - 55
IS - 1
SP - 197
EP - 199
AD - PLA, G. W.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721408728. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7, 7439-89-6.
N2 - Subjects deprived of food were given at 9 am 100 mg Fe as FeSO4 or ferric pyrophosphate alone or with 2 slices of enriched white bread, 2 hard-boiled eggs or 500 mg ascorbic acid in water. Plasma Fe estimated after 2 h was higher when bread or ascorbic acid had been taken but the effect of eggs was inconclusive. Subjects with lower haematocrits responded more to ingested Fe with or without food. The mean haematocrit was 37.7 for 3 women and 42.6 for 5 men.-A. H.
KW - ascorbic acid
KW - bread
KW - eggs
KW - food
KW - iron
KW - men
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - vitamin C
KW - Crop Produce (QQ050)
KW - Eggs and Egg Products (QQ040)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721408728&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Chemical composition of Mexican pineapple.
AU - BOLAND, F. E.
AU - BLOMQUIST, V. H.
AU - ESTRIN, B.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1972///
VL - 55
IS - 1
SP - 200
EP - 201
AD - BOLAND, F. E.: Division of Food Technology, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721408001. Publication Type: Journal Article. Language: English. Registry Number: 77-92-9, 57-50-1.
N2 - Values are tabulated for total soluble and insoluble solids, protein, invert sugar, sucrose, acidity as citric acid, total amino acids, ash, K2O, P2O5 and Na2O in 9 samples of canned and 9 of fresh pineapple.-A. H.
KW - acidity
KW - amino acids
KW - chemical composition
KW - citric acid
KW - pineapples
KW - sucrose
KW - Ananas comosus
KW - Ananas
KW - Bromeliaceae
KW - Bromeliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - saccharose
KW - Animal Nutrition (General) (LL500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721408001&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Derivative method for chemical confirmation of identity of aflatoxin M1.
AU - STACK, M. E.
AU - POHLAND, A. E.
AU - DANTZMAN, J. G.
AU - NESHEIM, S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1972///
VL - 55
IS - 2
SP - 313
EP - 314
AD - STACK, M. E.: Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19721407804. Publication Type: Journal Article. Language: English. Registry Number: 6795-23-9.
N2 - See also Abst. 7935.
KW - aflatoxins
KW - derivatives
KW - methodology
KW - mycotoxins
KW - techniques
KW - aflatoxin M1
KW - fungal toxins
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Weeds and Noxious Plants (FF500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721407804&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Effects of cyclamate and food restriction on various metabolites in the rat.
AU - PROSKY, L.
AU - O'DELL, R. G.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 1972///
VL - 27
IS - 2
SP - 353
EP - 363
SN - 0007-1145
AD - PROSKY, L.: Division of Nutrition, Food and Drug Administration, US Dept. Health, Education, and Welfare, Washington, DC 20204.
N1 - Accession Number: 19721408990. Publication Type: Journal Article. Language: English. Registry Number: 7440-70-2, 57-88-5.
N2 - Rats were given stock diets with different amounts of calcium cyclamate. Amounts up to 1% in the diet produced diarrhoea without affecting bodyweight. At 3% in the diet, bodyweight fell by 12% in 8 weeks. There were no changes in liver protein, lipid and RNA-P, and serum protein and lipid. 14CO2 output during the 1sth after glucose-14C was given also remained unchanged. Adult rats weighing 500 g were given a restricted diet with different fat cyclamate contents. During 15 weeks, those given a fat-supplemented diet with cyclamate lost twice as much weight as controls without cyclamate and also excreted 20% more 14CO2. When the intake was further restricted for 15 weeks weight losses in all groups were the same. Serum lipid and free cholesterol concentrations fell in the group given cyclamate. 14CO2 output for this group was 35% higher than for controls, indicating increased metabolic activity. Concentrations of aspartate, glutamate, lactate, succinate, malate and glycerol-l-phosphate in liver were within normal limits. There were indications of decreased lactate and succinate in rats given cyclamate which could be associated with aerobiosis and increased metabolic activity.
KW - animal models
KW - blood chemistry
KW - blood lipids
KW - blood proteins
KW - blood serum
KW - body weight
KW - calcium
KW - cholesterol
KW - diarrhoea
KW - diets
KW - food
KW - food restriction
KW - liver
KW - losses
KW - metabolites
KW - weight reduction
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - blood plasma proteins
KW - blood serum proteins
KW - diarrhea
KW - scouring
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721408990&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - The milk and food program of the Food and Drug Administration.
AU - FRITZ, J. H.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972///
VL - 62
IS - 3
SP - 414
EP - 418
SN - 0090-0036
AD - FRITZ, J. H.: Office of Food Sanitation, Bureau of Foods, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 19721409043. Publication Type: Journal Article. Language: English.
N2 - The work of the Division of catering and Milk Sanitation in the Food and Drug Administration of the United States and the organisational structure in which it functions are discussed. The author stresses the continuing need for attention to food-service sanitation, which is important in the work of the division.-W. W. H.
KW - catering
KW - food
KW - milk
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - food service
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721409043&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Myiasis in man by Cuterebra (Diptera : Cuterebridae).
AU - RICE, P. L.
AU - DOUGLAS, G. W.
JO - Annals of the Entomological Society of America
JF - Annals of the Entomological Society of America
Y1 - 1972///
VL - 65
IS - 2
SP - 514
EP - 516
SN - 0013-8746
AD - RICE, P. L.: Center for Disease Control, Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 19721001958. Publication Type: Journal Article. Language: English. Number of References: 7 ref.
N2 - A ten-year-old boy in Morganton, North Carolina, was found to have a first-instar larva of Cuterebra in a lesion over his eyebrows in 1962. In 1970, a third-instar larva of Cuterebra was removed from a lesion in the axilla of a seven-year-old boy from western Massachusetts. Details are also given of a further five cases of infestation of man by Cuterebra recorded in the literature.
KW - boys
KW - children
KW - infestation
KW - myiasis
KW - Massachusetts
KW - North Carolina
KW - USA
KW - Cuterebra
KW - Diptera
KW - man
KW - Cuterebridae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001958&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Observations of birds watering from small receptacles serving as potential mosquito-breeding sites [in Florida].
AU - HILL, E. F.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 1972///
VL - 65
IS - 2
SP - 608
EP - 609
SN - 0022-0493
AD - HILL, E. F.: Technical Development Laboratories, Center for Disease Control, Public Health Service, Savannah, Georgia 31402, USA.
N1 - Accession Number: 19721001722. Publication Type: Journal Article. Language: English. Number of References: 2 ref.
KW - irrigation
KW - Florida
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - North America
KW - America
KW - Developed Countries
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - United States of America
KW - watering
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721001722&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Effects of potassium depletion on renal tubular sodium and water re-absorption in the dog.
AU - ROSENBAUM, B.
AU - KINNEY, M. J.
AU - SCUDDER, F. C.
AU - DISCALA, V. A.
AU - STEIN, R. M.
JO - American Journal of Physiology
JF - American Journal of Physiology
Y1 - 1972///
VL - 222
IS - 4
SP - 928
EP - 937
SN - 0002-9513
AD - ROSENBAUM, B.: Renal Service, Dept. Medicine, Public Health Service Hospital, Staten Island 10304.
N1 - Accession Number: 19721408716. Publication Type: Journal Article. Language: English. Registry Number: 69-65-8.
N2 - Renal clearance studies were made on dogs to estimate the effects of K depletion (KD) on renal tubular Na and water transport. After KD, glomerular filtration rate (GFR) fell in all dogs. Under hydropenic conditions plus hypertonic mannitol loading, KD produced defects in Umax and TcH2O formation unassociated with changes in sodium excretion (CNa/Cosm), and (CNa/GFR). After water hydration and superimposed hypotonic mannitol loading, KD resulted in decreased Na excretion (CNa and CNa/GFR)/level of solute clearance (Cosm and Cosm/GFR, respectively); no appreciable change in the index of distal Na load (CH2O+CNa and (CH2O/GFR)+(CNa/GFR)/level of distal fluid supply (V and V/ GFR, respectively); and increased indices of distal Na transport (CH2O and CH2O/GFR)/level of distal Na load. During hypotonic saline loading, distal Na transport/distal Na load was either unchanged or increased after KD. The results suggest that the concentrating defect and the normal, or possibly increased, diluting capacity produced by KD in dogs are not consequent on either a decrease in ascending limb Na supply or transport, but rather seem to be due to diminished back diffusion of water at late distal tubular sites, perhaps in association with increased late distal Na transport.
KW - depletion
KW - effects
KW - excretion
KW - glomerular filtration rate
KW - kidneys
KW - mannitol
KW - research
KW - Germany
KW - dogs
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - small mammals
KW - eukaryotes
KW - Western Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - studies
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=gha&AN=19721408716&site=ehost-live&scope=site
DP - EBSCOhost
DB - gha
ER -
TY - JOUR
T1 - Research on the mosquitoes of Angola. VIII. The genus Aedes Meigen, 1818 (Diptera: Culicidae). Check-list with new records, keys to females and larvae, distribution and taxonomic and bioecological notes.
AU - Ribeiro, H.
AU - Ramos, H. da C.
JO - Anais do Instituto de Higiene e Medicina Tropical
JF - Anais do Instituto de Higiene e Medicina Tropical
Y1 - 1973///
VL - 1
IS - 1/4
SP - 107
EP - 138
SN - 0303-7762
AD - Ribeiro, H.: Public Health Service and Institute for Medical Research, Luanda, Angola.
N1 - Accession Number: 19740518570. Publication Type: Journal Article. Language: English. Language of Summary: Portuguese; French. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - In this eighth part of a series [cf. RAE/B 59, 193], a list is given of the 48 species of Aedes known from Angola, on the basis of all published data and the study of about 1700 adults and 3300 larvae caught by the authors in various parts of the country over a period of several years. Keys are provided to the females and fourth-instar larvae of Angolan species, which include 13 previously unrecognised in the country. Data are given as far as possible for each on the material examined by the authors, known distribution within Angola and ecology; taxonomic notes are included where appropriate. There are 140 new locality records. The distribution of each species is shown on a map. The medical importance of Angolan Aedes, mainly as vectors of arboviruses (particularly yellow fever and chikungunya viruses), is briefly reviewed. The species present include 22 potential vectors of arboviruses, of which many are known to be active in Angola. All known vectors of yellow fever virus are prevalent. It is believed that A. africanus (Theo.) and sylvan populations of A. aegypti (L.) are mainly responsible for maintaining enzootic sylvan yellow fever. A. aegypti queenslandensis (Theo.) is involved in the urban cycle of yellow fever [cf. 62, 1277, 1617] and was also responsible for an epidemic caused by chikungunya virus in Luanda in 1971.
KW - mosquito nets
KW - yellow fever
KW - Angola
KW - Aedes
KW - Aedes aegypti
KW - Aedes africanus
KW - chikungunya virus
KW - Culicidae
KW - Diptera
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Portuguese Speaking Africa
KW - Africa
KW - SADC Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - Aedes aegypti queenslandensis
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740518570&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Illustrated key to the Anopheline mosquitoes of Western South America.
AU - Gorham, J. R.
AU - Stojanovich, C. J.
AU - Scott, H. G.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1973///
VL - 5
IS - 2
SP - 97
EP - 156
SN - 0091-3669
AD - Gorham, J. R.: Arctic Health Research Center, Public Health Service, Fairbanks, Alaska 99701, USA.
N1 - Accession Number: 19730511433. Publication Type: Journal Article. Language: English; Spanish. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
KW - keys
KW - mosquito nets
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anophelinae
KW - mosquitoes
KW - western South America
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730511433&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Teratology studies on food colourings. 2. Embryotoxicity of R salt and metabolites of amaranth (FD & C Red No. 2) in rats.
AU - Collins, T. F. X.
AU - McLaughlin, J.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1973///
VL - 11
IS - 3
SP - 355
EP - 365
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Washington, D.C. 20204, USA.
N1 - Accession Number: 19731411851. Publication Type: Journal Article. Language: English. Language of Summary: French; German. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 2. Two metabolites, sodium naphthionate and the R-amino salt (the Na salt of 1-amino-2-naphthol-3,6-disulphonic acid), and one intermediate, R salt (2-naphthol-3,3-disulphonic acid Na salt), of the dye amaranth at 15, 30, 100 or 200 mg/kg day were given by tube to Osborne-Mendel rats during the first 19 days of pregnancy. There was a significant rise in the number of litters with multiple resorptions for those on the R salt 100 and 200 mg/kg and with sodium naphthioniate 200 mg/kg. Sodium naphthionate 100 mg/kg produced a significant rise in the percentage of foetuses with sternebral abnormalities but did not affect the number of soft tissue abnormalities in any dose. The R-amino salt 200 mg/kg significantly increased the incidence of litters with 1 or more foetuses with skeletal abnormalities but did not increase sternebral or soft tissue abnormalities. The R salt produced none of those effects.
KW - derivatives
KW - malformations
KW - Amaranthus
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Amaranthaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - amaranth derivatives
KW - congenital
KW - teratogeny
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731411851&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term toxicity studies of erythrosine. 1. Effects in rats and dogs.
AU - Hansen, W. H.
AU - Zwickey, R. E.
AU - Brouwer, J. B.
AU - Fitzhugh, O. G.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1973///
VL - 11
IS - 4
SP - 527
EP - 534
AD - Hansen, W. H.: Bureau of Foods, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19731413386. Publication Type: Journal Article. Language: English. Language of Summary: French; German. Registry Number: 16423-68-0. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 1. Groups of 12 male and 12 female weanling Osborne-Mendal rats were given a diet without or with erythrosine, a coal tar dye used in drugs, sweets, biscuits and other foods, 0.5, 1, 2 or 5% for 2 years. Growth of rats given 5% was significantly less than that of the other groups. Weight of spleen, expressed as organ weight:bodyweight ratio, was reduced in males on 0.5, 2 and 5% and in females on 5%. There was distension of the caecum in those on 1% or more. Weekly injections of erythrosine about 12 mg/rat were given to 18 rats for 2 years. Ulcerations were produced at the sites of injection but no tumours were found. The LD50 of erythrosine was 1840 mg/kg when given to rats by mouth. When erythrosine 0.5, 1 or 2% was given to 6 beagle dogs all survived the 2-year period and there was no effect attributable to erythrosine.
KW - additives
KW - caecum
KW - erythrosine
KW - foods
KW - intestines
KW - spleen
KW - toxicity
KW - weight
KW - dogs
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - adjuncts
KW - cecum
KW - disorders
KW - distension
KW - erythrosine b
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731413386&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term toxicity studies of erythrosine. 2. Effects on haematology and thyroxine and protein-bound iodine in rats.
AU - Hansen, W. H.
AU - Davis, K. J.
AU - Graham, S. L.
AU - Perry, C. H.
AU - Jacobson, K. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1973///
VL - 11
IS - 4
SP - 535
EP - 545
AD - Hansen, W. H.: Bureau of Foods, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19731413387. Publication Type: Journal Article. Language: English. Language of Summary: French; German. Registry Number: 16423-68-0, 7553-56-2. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 2. Groups of 50 Osborne-Mendel rats were given a diet without or with erythrosine 0.5, 1, 2 or 4% for 86 weeks. Other groups were given 100, 235, 750 or 1500 mg erythrosine/kg twice weekly by tube for 85 weeks. There was no consistent difference in erythrocyte count, haematocrit, Hb value, reticulocyte count or other indicator of anaemia. Increased protein-bound I was attributed to circulating erythrosine in the blood serum; values returned to normal 16 weeks after erythrosine was withdrawn.
KW - additives
KW - blood
KW - blood composition
KW - counting
KW - erythrocytes
KW - erythrosine
KW - foods
KW - haematocrit
KW - haemoglobin
KW - iodine
KW - reticulocytes
KW - toxicity
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adjuncts
KW - blood red cells
KW - erythrosine b
KW - hematocrit
KW - hemoglobin
KW - protein-bound
KW - red blood cells
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731413387&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relationships among urinary aminoimidazolecarboxamide in urine and folate, and vitamin B12 concentrations in serum.
AU - Harrison, J. W.
AU - Slade, B. A.
AU - Shaw, W.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1973///
VL - 19
IS - 9
SP - 1049
EP - 1052
SN - 0009-9147
AD - Harrison, J. W.: Nutritional Biochemistry Section, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, US Dep. HEW, Atlanta, Ga. 30333.
N1 - Accession Number: 19731414404. Publication Type: Journal Article. Language: English. Registry Number: 60-72-5, 68-19-9, 59-30-3. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Urinary aminoimidazolecarboxamide (AIC), serum folacin and serum vitamin B-12 were estimated in 84 apparently healthy individuals. An automated system for estimation of aic in urine is described. Despite claims to the contrary, there was no evidence of a strong relation between AIC excretion greater than 1.3 mu g/mg creatinine, as reflected in a casual sample of urine, and folacin or vitamin B-12 deficiency. Urinary AIC values ranged from 0.10 to 5.20 mu g/mg creatinine. The mean for the population examined was 1.36 plus or minus 1.02 mu g/mg creatinine.
KW - amides
KW - blood
KW - creatinine
KW - cyanocobalamin
KW - folic acid
KW - urine
KW - vitamin B12
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aminoimidazolecarboxamide
KW - cobalamin
KW - folacin
KW - folate
KW - relation to aminoimidazolecarboxamide in urine
KW - relation to creatinine in urine
KW - relation to folic acid and vitamin B-12 in blood
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731414404&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin A and carotene levels of a selected population in metropolitan Washington, D.C.
AU - Mitchell, G. V.
AU - Young, M.
AU - Seward, C. R.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1973///
VL - 26
IS - 9
SP - 992
EP - 997
SN - 0002-9165
AD - Mitchell, G. V.: Dep. Health, Education and Welfare, Food and Drug Administration, Office of Science, Bureau of Foods, Division of Nutrition, Washington, D.C. 20204.
N1 - Accession Number: 19731414617. Publication Type: Journal Article. Language: English. Registry Number: 68-26-8. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Vitamin A and carotene were estimated in liver samples obtained from subjects who died acute traumatic deaths or from various diseases in metropolitan Washington, D.C. Children under 2 months of age had the lowest mean liver concentrations of vitamin A and carotene; children from 2 months to 10 years of age and adults over 70 years had the highest mean concentrations. Of the samples studied, 24% had less than 50 mu g vitamin A/g liver and 3.3% had over 1000 mu g/g. Mean values of 211 mu g of vitamin A/g and 5.6 mu g of carotene/g were found in the livers of accident victims. Black males had a considerably lower concentration of vitamin A and carotene than had other groups within certain age ranges. Diseases, especially hepatic disease, also reduced vitamin A reserves. The large percentage of low vitamin A values found is attributed to nutritional inadequacies, and the high values to the wide use of vitamin supplements by infants, children and adults over 70 years old.
KW - age differences
KW - carotenes
KW - ethnic groups
KW - liver
KW - LIVER DISEASES
KW - RETINOL
KW - variation
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - disorders
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731414617&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Attempts to prevent disuse osteoporosis by treatment with calcitonin, longitudinal compression and supplementary calcium and phosphate.
AU - Hantman, D. A.
AU - Vogel, J. M.
AU - Donaldson, C. L.
AU - Friedman, R.
AU - Goldsmith, R. S.
AU - Hulley, S. B.
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
Y1 - 1973///
VL - 36
IS - 5
SP - 845
EP - 858
SN - 0021-972X
AD - Hantman, D. A.: Metabolic Unit, Dep. Medicine, US Public Health Service Hospital, 15th Ave. and Lake Street, San Francisco, Calif. 94118.
N1 - Accession Number: 19731413344. Publication Type: Journal Article. Language: English. Registry Number: 9007-12-9, 7440-70-2, 7723-14-0. Subject Subsets: Human Nutrition
N2 - During 19 weeks of continuous bed rest 100 MRC U synthetic salmon calcitonin daily did not prevent negative Ca and P balances in 2 healthy men; in one Ca and hydroxyproline values in urine were unusually high. Intermittent compression designed to simulate gravitational forces when walking did not substantially affect negative mineral balances. With supplements of Ca and phosphate increasing daily intakes of Ca from 1.0 to 1.8 or 2.3 and of P from 1.7 to 3.0 g, Ca balances were significantly less negative in 4 of 5 men than in controls; P balances became positive. Combined use of the 3 types of treatment was also beneficial.
KW - calcitonin
KW - calcium
KW - hormones
KW - phosphorus
KW - physical activity
KW - restricted feeding
KW - retention
KW - THYROID GLAND
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - calcium and phosphorus retention
KW - intake and of calcitonin
KW - prolonged bedrest
KW - thyrocalcitonin
KW - thyroid
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731413344&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - St. Louis encephalitis virus: an ultrastructural study of infection in a mosquito vector.
AU - Whitfield, S. G.
AU - Murphy, F. A.
AU - Sudia, W. D.
JO - Virology
JF - Virology
Y1 - 1973///
VL - 56
IS - 1
SP - 70
EP - 87
AD - Whitfield, S. G.: Center for Disease Control, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19740517572. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The course of St. Louis encephalitis virus infection in Culex pipiens pipiens L. was studied by electron microscopy. At the site of initial viral invasion of parenchyma in the mid-gut, epithelial infection involved a rather constant proportion of cells that yielded only moderate numbers of virus particles. Virus was observed in the mid-gut at locations where spread via the haemolymph could occur. Tissues in intimate contact with the haemolymph (the abdominal muscles, Malpighian tubes and ovarian sheath) became infected, but only moderate numbers of virus particles were ever produced. In sharp contrast, an ever increasing number of virus particles were formed in the epithelial cells of the salivary glands. Virus was primarily passed in to the cisternae of the endoplasmic reticulum and then shed from the apical end of the cells into the lumen of the glands. Very few particles were associated with the lateral or basal margins of the epithelium of the salivary glands. So much virus was shed into the limited space of the glandular lumen and its diverticula that dispersed particles formed into crystalline arrays from day 25 on; one of the largest of these crystals was estimated to contain more than 50 000 virus particles. Changes in the infected cells of all the mosquito organs examined were interpreted as physiological variations resulting from differences in feeding time and not as specifically due to viral cytopathology.
KW - clinical aspects
KW - infections
KW - mosquito nets
KW - Culex pipiens
KW - Culex pipiens pipiens
KW - Culicidae
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - viruses
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex pipiens
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - clinical picture
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740517572&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasma and whole blood concentrations of ascorbic acid in patients undergoing long-term hemodialysis.
AU - Bradley, D. W.
AU - Maynard, J. E.
AU - Webster, H.
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
Y1 - 1973///
VL - 60
IS - 2
SP - 145
EP - 147
SN - 0002-9173
AD - Bradley, D. W.: Center for Disease Control, Public Health Service, U.S. Dep. Health, Education, and Welfare, Phoenix, Ariz. 85014.
N1 - Accession Number: 19741416526. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Eighteen patients receiving a minimum of 2 haemodialysis treatments of 6 to 8 h duration each week and who were given 100 to 200 mg ascorbic acid daily showed an average loss of 41% of ascorbic acid from plasma and 18% from whole blood after a single dialysis treatment. Dietary supplements of ascorbic acid for patients undergoing long-term dialysis are recommended, with routine monitoring of ascorbic acid in small (0.1 ml) volumes of whole blood.
KW - ASCORBIC ACID
KW - dialysis
KW - renal failure
KW - requirements
KW - treatment
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dialysis treatment of renal failure
KW - kidney failure
KW - vitamin C
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741416526&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Actinomycotic lacrimal canaliculitis.
AU - Richards, W. W.
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
Y1 - 1973///
VL - 75
IS - 1
SP - 155
EP - 157
SN - 0002-9394
AD - Richards, W. W.: Public Health Service Hosp., San Francisco, Calif. 94118.
N1 - Accession Number: 19741309294. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A report of a case.
KW - effects
KW - USA
KW - Actinomyces
KW - man
KW - Actinomycetaceae
KW - Actinomycineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - lachrymal ducts
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741309294&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Novel diet preferences in potassium-deficient rats.
AU - Adam, W. R.
JO - Journal of Comparative and Physiological Psychology
JF - Journal of Comparative and Physiological Psychology
Y1 - 1973///
VL - 84
IS - 2
SP - 286
EP - 288
AD - Adam, W. R.: Dep. Medicine, Univ. Washington, US Public Health Service Hospital, P.O. Box 3145, Seattle, Wash. 98114.
N1 - Accession Number: 19731414730. Publication Type: Journal Article. Language: English. Registry Number: 7440-09-7. Subject Subsets: Animal Nutrition
N2 - Synthetic diets low in K and supplemented with sodium polystyrene sulphonate were given for 2 to 3 weeks to groups of 4 or 5 Sprague-Dawley rats, weighing 100 to 200 g, to produce K depletion. The procedure had previously been shown to produce 10 to 20% K depletion without adversely affecting weight gain. During the depletion period the diet for some groups of rats was diet A and for others diet B. In the next 24 h the rats were offered a choice of diet A or B. Each group preferred the novel to the familiar diet even when 4% KCl was added to the familiar diet or Na withheld from the novel diet. A control group of 6 rats which had been given diet A supplemented with 0.72% KCl for 2 or 3 weeks and not depleted of K preferred the familiar to the novel diet in the 24-h free choice period. Some of the groups were all male and others all female and there was no evidence of sex difference in diet preference.
KW - deficiency
KW - FEEDING PREFERENCES
KW - food preferences
KW - potassium
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet preferences
KW - feed preferences
KW - taste preferences
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731414730&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of protein and methionine on vitamin A liver storage in rats fed DDT.
AU - Young, M. L.
AU - Mitchell, G. V.
AU - Seward, C. R.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1973///
VL - 103
IS - 2
SP - 218
EP - 224
SN - 0022-3166
AD - Young, M. L.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19741408691. Publication Type: Journal Article. Language: English. Registry Number: 50-29-3, 63-68-3, 68-26-8. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Veterinary Science
N2 - Diets had 10 or 20% soya alpha-protein or casein as the protein source and were given alone or with 0.4% DL-methionine or 200 mg/kg DDT or both, to weanling Holtzman rats from 21 days old for 4 weeks. Methionine significantly increased food intakes and weight gains with 10 or 20% soya protein or 10% casein. Plasma vitamin A was increased by methionine added to any of the diets and also by DDT added to either of the casein diets though when both were added there was no synergistic effect and with both in the diet with 20% casein the increase was abolished. With either protein source there was more plasma vitamin A with 20 than with 10% protein. Methionine did not affect liver vitamin A on any diet but DDT depressed it except at the higher casein intake. Increasing diet protein did not increase vitamin A in the liver. Except with 20% casein, methionine increased the amount of DDT in the liver and it increased the ratio of DDE to DDT. The amount of DDT and its products and the concentration in mu g/mg lipid were less with 20 than with 10% soya protein but there was no such difference with casein diets. The conclusion is that the extent of toxicological stress from DDT exposure depends in large measure on the amount and quality of dietary protein.
KW - DDT
KW - dietary protein
KW - insecticides
KW - liver
KW - methionine
KW - pesticides
KW - protein
KW - Proteins
KW - RETINOL
KW - toxicity
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - dicophane
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741408691&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Non-surgical management of cystic hydatid disease in Alaska: a review of 30 cases of Echinococcus granulosus infection treated without operation.
AU - Pinch, L. W.
AU - Wilson, J. F.
JO - Annals of Surgery
JF - Annals of Surgery
Y1 - 1973///
VL - 178
IS - 1
SP - 45
EP - 48
SN - 0003-4932
AD - Pinch, L. W.: Surgical Service, Alaska Native Medical Center, US Public Health Service, Anchorage, Alaska, USA.
N1 - Accession Number: 19730807813. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - The clinical follow-up of 30 patients in Alaska, USA, with pulmonary cystic hydatid disease of the sylvatic form treated non-surgically supports the belief that the indigenous form of Echinococcus granulosus does not require aggressive surgical management.
KW - helminths
KW - hydatids
KW - parasites
KW - treatment
KW - Alaska
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19730807813&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vulnerability of children to lead exposure and toxicity.
AU - Lin-Fu, J. S.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1973///
VL - 289
IS - 23; 24
SP - 1229
EP - 1293
SN - 0028-4793
AD - Lin-Fu, J. S.: Office of Clinical Services, Health Services Administration, Public Health Service, US Dep. Health, Education, and Welfare, Rockville, Md. 20852.
N1 - Accession Number: 19741418837. Publication Type: Journal Article. Language: English. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
KW - children
KW - lead
KW - poisoning
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - disorders
KW - toxicosis
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741418837&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The occurrence and distribution of resistance in lice [Pediculus humanus L. and Phthirus pubis (L.)].
AU - Schoof, H. F.
JO - Scientific Publication, Pan American Health Organization
JF - Scientific Publication, Pan American Health Organization
Y1 - 1973///
IS - 263
SP - 223
EP - 226
AD - Schoof, H. F.: Center for Disease Control, U.S. Public Health Service, Savannah, Georgia, USA.
N1 - Accession Number: 19740514154. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
KW - insecticide resistance
KW - Pediculus humanus
KW - Pthirus
KW - Pthirus pubis
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pthirus
KW - Pthiridae
KW - body louse
KW - crab louse
KW - Phthirus
KW - Phthirus pubis
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740514154&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biochemistry of DDT resistance in the human body louse Pediculus humanus humanus.
AU - Perry, A. S.
JO - Scientific Publication, Pan American Health Organization
JF - Scientific Publication, Pan American Health Organization
Y1 - 1973///
IS - 263
SP - 226
EP - 229
AD - Perry, A. S.: Center for Disease Control, U.S. Public Health Service, Savannah, Georgia, USA.
N1 - Accession Number: 19740514155. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 50-29-3. Subject Subsets: Medical & Veterinary Entomology
KW - DDT
KW - insecticide resistance
KW - resistance
KW - Pediculus humanus
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pediculus humanus
KW - body louse
KW - dicophane
KW - Pediculus humanus humanus
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740514155&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trace elements in milk.
AU - Murthy, G. K.
JO - CRC Critical Reviews in Environmental Control
JF - CRC Critical Reviews in Environmental Control
Y1 - 1974///
VL - 4
IS - 1
SP - 1
EP - 37
AD - Murthy, G. K.: Bureau of Foods, US Food and Drug Administration, Cincinnati, Ohio, USA.
N1 - Accession Number: 19740414059. Publication Type: Journal Article. Language: English. Number of References: 177 ref. Registry Number: 7439-96-5, 7439-97-6, 7439-98-7, 7440-02-0, 7440-17-7, 7782-49-2, 7440-21-3, 7440-22-4, 7440-24-6, 7440-32-6, 7440-62-2, 7440-66-6, 7429-90-5, 7440-38-2, 7440-39-3, 7440-42-8, 7726-95-6, 7440-43-9, 7440-47-3, 7440-48-4, 7440-50-8, 16984-48-8, 7553-56-2, 7439-89-6, 7439-92-1. Subject Subsets: Human Nutrition; Dairy Science; Veterinary Science
N2 - This review covers analytical methods, contents, of Cu, Fe, Mn, I, Se, Zn, Mo, Co, F. Cr, Al, Cd, Pb, Ni, As, B, Br, Hg, Rb, Ag and Sr in cows' milk, and contents of Cu, Fe, Mn, Zn, Al, Cr, Co, Pb, Ni, Se, Si, Sr, Ti, V and Ba in human milk. It also considers trace elements in infant feeds and feeding.
KW - aluminium
KW - arsenic
KW - barium
KW - boron
KW - bromine
KW - cadmium
KW - chromium
KW - cobalt
KW - composition
KW - copper
KW - cows
KW - fluoride
KW - human milk
KW - iodine
KW - iron
KW - lead
KW - manganese
KW - mercury
KW - milk
KW - milk composition
KW - Minerals
KW - molybdenum
KW - nickel
KW - reviews
KW - rubidium
KW - selenium
KW - silicon
KW - silver
KW - strontium
KW - titanium
KW - trace elements
KW - vanadium
KW - zinc
KW - cattle
KW - MAN
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - aluminum
KW - breast milk
KW - microelements
KW - milk constituents
KW - Mn
KW - Mo
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740414059&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of methionine on liver lipids, vitamin A, and fatty acids in rats fed amino acid diets containing DDT.
AU - Young, M. L.
AU - Mitchell, G. V.
AU - Seward, C. R.
AU - Adkins, J. S.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1974///
VL - 9
IS - 1
SP - 1
EP - 8
AD - Young, M. L.: Division of Nutrition, Food and Drug Administration, US Dep. Health, Education, and Welfare, Washington, D.C. 20204.
N1 - Accession Number: 19741418725. Publication Type: Journal Article. Language: English. Registry Number: 50-29-3, 63-68-3, 68-26-8. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Male weanling Holtzman rats were given a purified amino acid diet (equivalent to 19% protein) supplemented with 0.4, 1.0 or 2.0% DL-methionine. At each amount of methionine supplementation DDT was added to the diet at 50, 100 and 200 mg/kg. There was no significant change in growth with 0.4 and 1.0% methionine; growth was reduced by 13% and total liver lipid was significantly increased when the methionine supplement was increased from 1.0 to 2.0% of the diet. The amount of vitamin A stored in the liver fell with an increase of DDT at all methionine values. As the amount of methionine was increased, liver vitamin A was reduced significantly in rats on 100 and 200 mg DDT/kg. The results indicate that the amounts of both DDT and methionine effect the storage of vitamin A in the liver of rats on a purified amino acid diet.
KW - DDT
KW - insecticides
KW - intake
KW - lipids
KW - liver
KW - methionine
KW - RETINOL
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - dicophane
KW - lipins
KW - modification by methionine intake
KW - modification of effect of DDT intake on lipids and vitamin A in liver
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741418725&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Northway virus: a new Bunyamwera group arbovirus from Alaska.
AU - Calisher, C. H.
AU - Lindsey, H. S.
AU - Ritter, D. G.
AU - Sommerman, K. M.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 1974///
VL - 20
IS - 2
SP - 219
EP - 223
SN - 0008-4166
AD - Calisher, C. H.: Arbovirus Section, Center for Disease Control, U.S. Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19740521106. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Six strains of virus of the Bunyamwera group were isolated in eastern and central Alaska in 1970-71. One was from a pool of Aedes spp., one from a pool of mosquitos of the complex of Aedes hexodontus Dyar, one from Culiseta alaskaenis (Ludl.) and 3 from sentinel rabbits. The six strains appeared to be identical to each other and different from other arboviruses, and the virus is named Northway virus.
KW - mosquito nets
KW - Alaska
KW - USA
KW - Aedes
KW - Aedes hexodontus
KW - Culicidae
KW - Culiseta alaskaensis
KW - Diptera
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Culiseta
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - complex
KW - mosquitoes
KW - Northway virus
KW - Ochlerotatus
KW - Ochlerotatus hexodontus
KW - United States of America
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740521106&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Further studies on tularemia in Alaska: virulence and biochemical characteristics of indigenous strains.
AU - Miller, L. G.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 1974///
VL - 20
IS - 11
SP - 1585
EP - 1590
SN - 0008-4166
AD - Miller, L. G.: Division of Quality and Standards, Public Health Service, Dallas, Texas 75202, USA.
N1 - Accession Number: 19750523204. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - In the summer of 1971 a high rate of mortality was noted among hares (Lepus americanus) near Fairbanks, Alaska. An investigation to identify pathogens that might be involved led to several isolations of Pasteurella (Francisella) tularensis from both the hares and from Haemaphysalis leporispalustris (Pack.) collected from the hares. The biochemical characteristics of the strain from hares are described.
KW - Alaska
KW - USA
KW - Acari
KW - FRANCISELLA TULARENSIS
KW - Haemaphysalis leporispalustris
KW - Lepus americanus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Haemaphysalis
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Lepus
KW - Leporidae
KW - Lagomorpha
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - Pasteurella tularensis
KW - United States of America
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750523204&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modified antigens in the indirect immunofluorescence test for schistosomiasis.
AU - Wilson, M.
AU - Sulzer, A. J.
AU - Walls, K. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1974///
VL - 23
IS - 6
SP - 1072
EP - 1076
SN - 0002-9637
AD - Wilson, M.: Center for Disease Control, Public Health Service, U.S. Dept. of Health, Education & Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19750817665. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - Frozen sections of Schistosoma mansoni adults and cercariae were used as slide antigens in the indirect immunofluorescence test. Unfixed adults embedded in Tissue-Tek O.C.T. medium for frozen sectioning, gave the best combination of sensitivity and specificity. Cercarial antigens reacted intensely with Trichinella antisera. Frozen S. mansoni and S. haematobium adult antigens showed sensitivities of 91.7% and 85.4%, respectively, whilst specificities were 95.8% and 96.9%, respectively. Species determination by serology was not possible. [AS]
KW - diagnosis
KW - helminths
KW - IMMUNOFLUORESCENCE
KW - immunology
KW - parasites
KW - schistosomiasis
KW - techniques
KW - man
KW - Schistosoma
KW - Trematoda
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - fluorescent antibody technique
KW - IFAT
KW - parasitic worms
KW - parasitolog
KW - schistosomosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750817665&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on the effects of anticonvulsant drugs on the activity of vitamin D in rats and dogs.
AU - Balazs, T.
AU - Hooper, W.
AU - Farber, T. M.
AU - Loon, E. J. Van
AU - Earl, F. L.
AU - Weinberger, M. A.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1974///
VL - 29
IS - 1
SP - 47
EP - 52
SN - 0041-008X
AD - Balazs, T.: Bureau of Drugs, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19741426584. Publication Type: Journal Article. Language: English. Registry Number: 50-06-6, 1406-16-2. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Rats on a rachitogenic diet from weaning were kept in a regulated cycle of 12 h each of light and darkness and were given at 7 to 8 weeks of age intraperitoneal injections of sodium phenobarbital 40 to 60 mg/kg, sodium diphenylhydantoin 15 to 30 mg/kg or a combination of both drugs 30 and 10 mg/kg, respectively, daily for 9 to 10 days. Rats from each group were given cholecalciferol by gastric tube 1.87 or 3.75 units on days 7 and 10 of the individual drug treatments and 0.95 unit on days 7 and 9 of the combined drug treatment. Animals were killed 4 to 5 days after the second dose of cholecalciferol. Rickets developed to the same extent in all rats that did not receive vitamin D, with or without the anticonvulsant drugs. In adult dogs given sodium phenobarbital, 35 mg/kg daily for 20 months mixed in a normal diet, liver microsomal enzyme induction developed, but osteomalacia did not.
KW - anticonvulsants
KW - barbiturates
KW - bones
KW - deficiency
KW - enzymes
KW - liver
KW - metabolism
KW - phenobarbital
KW - prevention
KW - vitamin D
KW - vitamin deficiencies
KW - DOGS
KW - RATS
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741426584&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health criteria for processed wastes.
AU - Taylor, J. C.
AU - Gable, D. A.
AU - Graber, G.
AU - Lucas, E. W.
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1974///
VL - 33
IS - 8
SP - 1945
EP - 1946
SN - 0014-9446
AD - Taylor, J. C.: Division of Nutritional Sciences, Bureau of Veterinary Medicine, Food and Drug Administration, Dep. Health, Education and Welfare, 5600 Fishers Lane, Rockvill,e, Md. 20852, USA.
N1 - Accession Number: 19741425330. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Veterinary Science
KW - faeces
KW - health
KW - public health
KW - waste disposal
KW - wastes
KW - feces
KW - health criteria
KW - risks from processed waste
KW - Animal Nutrition (Production Responses) (LL520)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741425330&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An analysis of Culex tarsalis Coquillett laboratory rearing productivity.
AU - Hayes, R. O.
AU - Montoya, M.
AU - Smith, G. C.
AU - Francy, D. B.
AU - Jakob, W. L.
JO - Mosquito News
JF - Mosquito News
Y1 - 1974///
VL - 34
IS - 4
SP - 462
EP - 466
AD - Hayes, R. O.: Vector-Borne Diseases Division, Public Health Service, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19750523230. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 79-57-2. Subject Subsets: Medical & Veterinary Entomology
N2 - In the best of 11 feeding regimes for larvae of Culex tarsalis Coq. tested in the laboratory, a commercial fish-food containing 46% protein was added to the rearing water at the rate of 0.2 mg/larva per day for two weeks, and Terramycin at the rate of 0.029 mg/larva was added on the day of hatching and on days 4, 8 and 12 afterwards. On average, 100 larvae reared in this way gave rise to 70 pupae and 58 adults. The rearing methods and the results obtained with the other regimes are described.
KW - mosquito nets
KW - oxytetracycline
KW - rearing techniques
KW - synthetic diets
KW - techniques
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - artificial diets
KW - fish-food
KW - monohydrochloride
KW - mosquitoes
KW - terramycin
KW - Techniques and Methodology (ZZ900)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750523230&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Laboratory vs field results with phoxim as a mosquito larvicide.
AU - Wilton, D. P.
JO - Mosquito News
JF - Mosquito News
Y1 - 1974///
VL - 34
IS - 4
SP - 469
EP - 471
AD - Wilton, D. P.: Central America Research Station, U. S. Public Health Service, San Salvador, El Salvador.
N1 - Accession Number: 19750523233. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 14816-18-3. Subject Subsets: Medical & Veterinary Entomology
N2 - In laboratory tests against larvae of Anopheles albimanus Wied. in aluminium pans, a bait containing phoxim applied at 0.13 mg toxicant/m2 was as effective when the water temperature was 35 deg C as when it was 21-24 deg C, causing 100% mortality after 24 h in each case. However, a bait applied at 0.23 mg toxicant/m2 was much less effective in pans exposed to sunlight for 4 h and then put in the shade than in others kept in the shade, the average mortalities being 10 and 94.5%, respectively. A further test showed that phoxim applied at 0.23 mg/m2 became completely ineffective after exposure to sunlight for 4 h. This rapid degradation in sunlight explains why the larvicide has generally given poor results in field applications.
KW - chemical control
KW - control
KW - insecticides
KW - mosquito nets
KW - phoxim
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - sunlight inactivation
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
KW - Other Control Measures (HH700)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750523233&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of essential minerals on cadmium toxicity. A review.
AU - Fox, M. R. S.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1974///
VL - 39
IS - 2
SP - 321
EP - 324
SN - 0022-1147
AD - Fox, M. R. S.: Division of Nutrition, Bureau of Foods, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, DC 20204, USA.
N1 - Accession Number: 19741420193. Publication Type: Journal Article. Language: English. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
KW - cadmium
KW - minerals
KW - reviews
KW - toxicity
KW - essential minerals
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741420193&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Advances in the immunodiagnosis of parasitic infections.
AU - Kagan, I. G.
JO - Zeitschrift fur Parasitenkunde
JF - Zeitschrift fur Parasitenkunde
Y1 - 1974///
VL - 45
IS - 2
SP - 163
EP - 195
AD - Kagan, I. G.: Centre for Disease Control, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19750816997. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - This is a very useful review covering the use of the standard serological tests and their application to the important helminth and protozoan diseases of man. Recent work and the direction of future research in the development of immunodiagnosis is discussed. There are over 150 references.
KW - diagnosis
KW - helminths
KW - immunodiagnosis
KW - immunology
KW - parasites
KW - protozoal infections
KW - reviews
KW - techniques
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - parasitic worms
KW - parasitolog
KW - protozoal diseases
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750816997&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selected body measurements in boys ages 6-11 years from six villages in Southern Tunisia: an international comparison.
AU - Lowenstein, F. W.
AU - O'Connell, D. E.
JO - Human Biology
JF - Human Biology
Y1 - 1974///
VL - 46
IS - 3
SP - 471
EP - 482
SN - 0018-7143
AD - Lowenstein, F. W.: National Center for Health Statistics, Division of Health Examination Statistics, Public Health Service, 5600 Fishers Lane, Rockville, Md. 20852, USA.
N1 - Accession Number: 19741426189. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - There were greater differences in anthropometric values between Tunisian groups of different socioeconomic status than between privileged Tunisians and USA groups of similar status but different race.
KW - body measurements
KW - children
KW - Tunisia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Francophone Africa
KW - Africa
KW - Maghreb
KW - North Africa
KW - Mediterranean Region
KW - Threshold Countries
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741426189&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunofluorescent staining of plasmodial oocysts in the mosquito.
AU - Krotoski, W. A.
AU - Omar, M. S.
AU - Jumper, J. R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1974///
VL - 60
IS - 2
SP - 344
EP - 347
SN - 0022-3395
AD - Krotoski, W. A.: Department of Medicine, U.S. Public Health Service Hospital, San Francisco, California 94118, USA.
N1 - Accession Number: 19740516738. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Mosquitos infected with Plasmodium cynomolgi bastianellii were fixed in Carnoy's solution and embedded in a paraffine-base medium and then were sectioned and submitted to an indirect fluorescent antibody test employing antiserum prepared to blood stages from the vertebrate host. Bright specific fluorescence clearly differentiated plasmodial oocysts from adjacent mosquito tissue and permitted some correlation of antigenic sites with predominatly non-nucleic components of the parasite. The ability of antibodies directed against the blood stages to combine specifically with intermediate forms within the sporogonic cycle in the mosquito confirms the existence of antigenic material throughout the greater portion of the parasite's life-cycle.
KW - detection
KW - Culicidae
KW - Diptera
KW - Plasmodium cynomolgi
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - mosquitoes
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740516738&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neonatal malnutrition:: neurochemical, hormonal and behavioral manifestations.
AU - Sobotka, T. J.
AU - Cook, M. P.
AU - Brodie, R. E.
JO - Brain Research
JF - Brain Research
Y1 - 1974///
VL - 65
IS - 3
SP - 443
EP - 457
SN - 0006-8993
AD - Sobotka, T. J.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19751430227. Publication Type: Journal Article. Language: English. Registry Number: 9000-71-9. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - During lactation mother rats were given a diet with 12 or 24% casein. The malnourished young of dams on 12% casein had reduced body growth and delayed eye opening. At weaning brain weight was reduced and there was distortion of its chemical composition. The changes included a general reduction of cholesterol concentration, decreased cerebellar DNA and reduced telencephalic and brain stem protein:DNA ratios. The cerebellum had low acetylcholinesterase activity which suggested an effect on its synaptic elements, particularly involving the cholinergic system. Brain stem concentrations of serotonin and 5-hydroxyindoleacetic acid rose, implying activation of the central serotonergic neurohumoral system. There was a concomitant rise in adrenal corticosterone. The previously malnourished weanlings showed heightened emotionality and their performance in a 2-way shuttle task was abnormal.
KW - brain
KW - casein
KW - change
KW - feeding
KW - feeds
KW - lactation
KW - malnutrition
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - before weaning
KW - brain composition and weight
KW - cerebrum
KW - composition and weight
KW - feeding stuffs
KW - maternal protein intake
KW - Animal Nutrition (General) (LL500)
KW - Human Nutrition (General) (VV100)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751430227&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changes in plasma zinc related to fasting and dietary protein intake of Japanese quail.
AU - Harland, B. F.
AU - Fox, M. R. S.
AU - Fry, B. E., Jr.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1974///
VL - 145
IS - 1
SP - 316
EP - 322
SN - 0037-9727
AD - Harland, B. F.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, DC 20204, USA.
N1 - Accession Number: 19741423671. Publication Type: Journal Article. Language: English. Registry Number: 7440-66-6. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Day-old Japanese quail, Coturnix coturnix japonica, were given a diet containing 35% soya bean protein for 4 weeks. Total Zn in the diet was 7 mg/kg. Some diets were supplemented with zinc carbonate to provide 75 mg Zn/kg diet. The effect of 24-h fasting followed by feeding with Zn supplements for 4 h was estimated at 4 weeks of age. The supplements ranged from whole diets of egg white to single dietary components of glucose and a maize oil:ground cellulose mixture. By week 4, the bodyweights averaged 46 and 82 g for birds eating the diet with 7 and 75 mg Zn/kg. In Zn-deficient birds mean plasma Zn was 62 mu g/100 ml and was not altered by fasting. Birds given 75 mg Zn had higher plasma Zn values. Fasting for 24 h or feeding on a low-Zn soya bean protein diet for 24 h did not alter plasma Zn. Plasma Zn decreased notably when the birds were fasted and refed on a low-Zn diet for 4 h. Birds given 25 mg Zn/kg diet grew normally but had lower plasma Zn values than birds getting 75 mg Zn/kg diet. When birds originally given 75 mg Zn/kg diet were fed on the low-Zn diet for 24 h there was a drop in plasma Zn. The different protein supplements given for 4 h to the birds fed on the 75 mg Zn diet to 4 weeks of age and starved for 24 h caused a larger decline in plasma Zn than did a 24-h fast alone. Birds fed on glucose and Zn or maize oil with cellulose and Zn had higher plasma Zn values than birds given corresponding low-Zn supplements. The conclusion was that during rapid protein metabolism there was a significant decrease in plasma Zn.
KW - blood
KW - intake
KW - poultry
KW - protein intake
KW - proteins
KW - starvation
KW - zinc
KW - Japanese quails
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - domesticated birds
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741423671&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Volume expansion and intrarenal blood flow of normal and salt-deprived rats.
AU - Kinney, M. J.
AU - DiScala, V. A.
JO - American Journal of Physiology
JF - American Journal of Physiology
Y1 - 1974///
VL - 227
IS - 3
SP - 652
EP - 656
SN - 0002-9513
AD - Kinney, M. J.: Renal Service, US Public Health Service Hospital, Staten Island, N.Y. 10304, USA.
N1 - Accession Number: 19741426340. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
KW - blood
KW - blood flow
KW - deprivation
KW - flow
KW - kidneys
KW - salt
KW - volume
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood volume and intrarenal flow
KW - salt deprivation
KW - Animal Nutrition (Physiology) (LL510)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19741426340&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Developing a model chick diet for studying diet-drug interactions.
AU - Graber, G.
AU - Colaianne, J. J.
AU - Goatcher, W. D.
AU - Lucas, E. W.
AU - Norvell, M. J.
AU - Thomas, M. C.
T2 - Proceedings 1974 Maryland Nutrition Conference for Feed Manufacturers, March 14-15, 1974.
JO - Proceedings 1974 Maryland Nutrition Conference for Feed Manufacturers, March 14-15, 1974.
JF - Proceedings 1974 Maryland Nutrition Conference for Feed Manufacturers, March 14-15, 1974.
Y1 - 1974///
SP - 47
EP - 52
CY - College Park, Md.; USA
PB - University of Maryland.
AD - Graber, G.: Division of Nutritional Sciences, Bureau of Veterinary Medicine, Food and Drug Administration, Rockville, Md. 20852, USA.
N1 - Accession Number: 19751433862. Publication Type: Conference paper. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
KW - diets
KW - drugs
KW - estimation
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - diet-drug interactions
KW - domesticated birds
KW - interaction with drugs
KW - interaction with feed
KW - medicines
KW - pharmaceuticals
KW - Animal Nutrition (Production Responses) (LL520)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751433862&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Comparison of light trap and human-biting captures of Anophelines in El Salvador.
AU - Wilton, D. P.
A2 - Mulhern, T. D.
T2 - Proceedings and Papers of the Forty-second Annual Conference of the California Mosquito Control Association, Inc. and the Thirtieth Annual Meeting of the American Mosquito Control Association, Inc., February 24-27, 1974, held at the Disneyland Hotel, Anaheim, California.
JO - Proceedings and Papers of the Forty-second Annual Conference of the California Mosquito Control Association, Inc. and the Thirtieth Annual Meeting of the American Mosquito Control Association, Inc., February 24-27, 1974, held at the Disneyland Hotel, Anaheim, California.
JF - Proceedings and Papers of the Forty-second Annual Conference of the California Mosquito Control Association, Inc. and the Thirtieth Annual Meeting of the American Mosquito Control Association, Inc., February 24-27, 1974, held at the Disneyland Hotel, Anaheim, California.
Y1 - 1974///
SP - 167
EP - 167
CY - Visalia, California 93277; USA
PB - CMCA Press.
AD - Wilton, D. P.: CARS/CDC, U. S. Public Health Service, c/o U. S. Embassy, APO New York 09889, USA.
N1 - Accession Number: 19750522455. Publication Type: Conference paper. Language: English. Subject Subsets: Medical & Veterinary Entomology
N2 - Catches of Anophelines (mainly Anopheles albimanus Wied.) in a New Jersey, a miniature CDC and a new ultraviolet-updraft light-trap were compared with catches on man at various places in El Salvador. The catches on man were usually higher than those in the traps, but when the population density was low, catches in the ultraviolet-light trap often equalled and occasionally exceeded them. The parous rate of females caught in traps was nearly twice that of females coming to man, suggesting that newly emerged and older females respond differently to the two types of attractant.
KW - New Jersey light traps
KW - traps
KW - El Salvador
KW - Anopheles albimanus
KW - Culicidae
KW - man
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - light-trap, miniature CDC
KW - light-trap, ultraviolet-updraft
KW - mosquitoes
KW - Salvador
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750522455&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Some effects of high dietary levels of various salts of copper in broiler chickens.
AU - Norvell, M. J.
AU - Thomas, M. C.
AU - Goatcher, W. D.
AU - Gable, D. A.
AU - Calvert, C. C.
A2 - Hemphill, D. D.
T2 - Trace substances in environmental health. 8. Proceedings of University of Missouri's 8th Annual Conference on trace substances in environmental health.
JO - Trace substances in environmental health. 8. Proceedings of University of Missouri's 8th Annual Conference on trace substances in environmental health.
JF - Trace substances in environmental health. 8. Proceedings of University of Missouri's 8th Annual Conference on trace substances in environmental health.
Y1 - 1974///
SP - 367
EP - 372
CY - Columbia, Missouri; USA
PB - University of Missouri.
AD - Norvell, M. J.: Division of Nutritional Sciences, Bureau of Veterinary Medicine, Food and Drug Administration, Rockville, Md., USA.
N1 - Accession Number: 19751433343. Publication Type: Conference paper. Language: English. Registry Number: 7440-50-8. Subject Subsets: Animal Nutrition; Human Nutrition
KW - copper
KW - effects
KW - metabolism
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - disorders
KW - domesticated birds
KW - Animal Nutrition (Physiology) (LL510)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751433343&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology of Echinococcus in the United States.
AU - Kagan, I. G.
T2 - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 1.
JO - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 1.
JF - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 1.
Y1 - 1974///
SP - 555
EP - 555
CY - Vienna; Austria
PB - FACTA Publication.
AD - Kagan, I. G.: Centre for Disease Control, Public Health Service, US Dept. of Health, Education & Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19740816372. Publication Type: Conference paper. Language: English. Subject Subsets: Helminthology
N2 - [Echinococcus granulosus, E. multilocularis]
KW - alveolar hydatids
KW - epidemiology
KW - helminths
KW - hydatids
KW - parasites
KW - USA
KW - animals
KW - Echinococcus granulosus
KW - Echinococcus multilocularis
KW - man
KW - eukaryotes
KW - Echinococcus
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alveolar hydatid
KW - Cyclophyllidea
KW - multilocular hydatids
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740816372&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Trichinellosis in California: a 52-year review.
AU - Lyman, D. O.
A2 - Kim, C.W.
T2 - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
JO - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
JF - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
Y1 - 1974///
SP - 571
EP - 577
CY - New York; USA
PB - Intext Educational Publishers.
AD - Lyman, D. O.: Cent. for Disease Control Health Services and Mental Health Administration Public Health Service, Berkeley, California, USA.
N1 - Accession Number: 19760825299. Publication Type: Miscellaneous. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - Human cases of trichinelliasis in California, USA, in 1920-71 are reviewed. The high number of cases in the Thirties is thought to be attributable to the fact that it was the period of the Depression and pork was relatively inexpensive. The disease pattern in the last 20 years has changed to a spring-summer predominance among people in their 30s, which cannot be conclusively explained. Wild bear meat was the source of 16 of 41 classes reported in 1970-71. Of 44 deaths since 1920, only 5 occurred after 1950. The food source was home prepared meat of pig or bear origin.
KW - Disease surveys
KW - epidemiology
KW - helminths
KW - incidence
KW - Meat hygiene
KW - nematode infections
KW - parasites
KW - swine diseases
KW - Pacific States of USA
KW - USA
KW - Enoplida
KW - man
KW - pigs
KW - Trichinella
KW - Trichinella spiralis
KW - Ursidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Trichinellidae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Nematoda
KW - invertebrates
KW - Trichinella
KW - Fissipeda
KW - carnivores
KW - Enoplia
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Adenophorea
KW - disease surveillance
KW - hogs
KW - nematodes
KW - parasitic worms
KW - pig diseases
KW - swine
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760825299&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Trichinellosis surveillance in the United States.
AU - Schultz, M. G.
AU - Juranek, D. D.
A2 - Kim, C.W.
T2 - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
JO - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
JF - Trichinellosis. Proc. 3rd Int. Conf. on Trichinellosis, Florida, USA, 2-4 Nov. 1972.
Y1 - 1974///
SP - 593
EP - 595
CY - New York; USA
PB - Intext Educational Publishers.
AD - Schultz, M. G.: Cent. for Disease Control, U.S. Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 19760825281. Publication Type: Miscellaneous. Language: English. Subject Subsets: Human Nutrition; Helminthology; Veterinary Science
N2 - Data for 1947 to 1971 are reviewed.
KW - animal diseases
KW - helminths
KW - incidence
KW - meat inspection
KW - nematode infections
KW - parasites
KW - wild animals
KW - USA
KW - Enoplida
KW - man
KW - PIGS
KW - Trichinella
KW - Trichinella spiralis
KW - Ursidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Trichinellidae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Nematoda
KW - invertebrates
KW - Trichinella
KW - Fissipeda
KW - carnivores
KW - Enoplia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Adenophorea
KW - hogs
KW - nematodes
KW - parasitic worms
KW - swine
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Meat Produce (QQ030)
KW - Food Composition and Quality (QQ500)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760825281&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Protection of Schistosoma mansoni elicited in the rhesus monkey by hyperimmune serum combined with a cellular component.
AU - Kagan, I. G.
AU - Maddison, S. E.
T2 - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 2.
JO - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 2.
JF - Third International Congress of Parasitology. Munich, August 25-31 1974. Proceedings, Vol. 2.
Y1 - 1974///
SP - 1167
EP - 1167
CY - Vienna; Austria
PB - FACTA Publication.
AD - Kagan, I. G.: Center for Disease Control, Public Health Service, U.S. Dept. of Health, Education & Welfare, Atlanta, Georgia, U.S.A.
N1 - Accession Number: 19740817463. Publication Type: Conference paper. Language: English. Subject Subsets: Helminthology
KW - helminths
KW - immunity
KW - parasites
KW - passive immunity
KW - Macaca mulatta
KW - Primates
KW - Schistosoma mansoni
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - parasitic worms
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19740817463&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term effects of dietary Amaranth in rats. 1. Effects on reproduction.
AU - Collins, T. F. X.
AU - Keeler, H. V.
AU - Black, T. N.
AU - Ruggles, D. I.
JO - Toxicology
JF - Toxicology
Y1 - 1975///
VL - 3
IS - 1
SP - 115
EP - 128
SN - 0300-483X
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19751438647. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 1. A stock diet without or with the red dye Amaranth 30, 300, 3000 or 30 000 mu g/g was given to Osborne-Mendel rats for 3 generations. Amaranth did not affect fertility, mean litter size, mean number of liveborn young, viability or survival of offspring. Weight of weanling rats of the group given 30 000 mu g/g was significantly reduced in females of the fourth litter of the first generation and in males and females in the first and third litters of the second generation. No effect of the dye could be distinctly linked with any specific generation and no cumulative effect was apparent.
KW - additives
KW - foods
KW - toxicity
KW - Amaranthus
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Amaranthaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - adjuncts
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751438647&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term effects of dietary Amaranth in rats. 2. Effects on fetal development.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Ruggles, D. I.
JO - Toxicology
JF - Toxicology
Y1 - 1975///
VL - 3
IS - 1
SP - 129
EP - 140
SN - 0300-483X
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19751438648. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 2. Amaranth was given to Osborne-Mendel rats as in the previous abst. Progeny used to study developmental effects were obtained from matings of the first litters of the first generation (F1A) and of the second litters of the second generation (F2B) and were termed F1A1 and F3B, respectively. Mean weight gain and food intake were not affected by Amaranth in the diet. In F1A rats the number of corpora lutea was significantly less in those given 30 000 mu g/g than in controls and this affected the number of progeny, but the pre-implantation loss per litter did not differ from that for the controls. Increases in F1A resorptions and a decrease in mean foetal weight of the progeny were not related to the amount of Amaranth given. There was no difference in implantation or foetal survival values between F2B rats and controls. No specific abnormality of skeletal or soft tissue could be correlated to amount of the dye given in F1A1 or F3B rats.
KW - additives
KW - foods
KW - toxicity
KW - Amaranthus
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Amaranthaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - adjuncts
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751438648&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chagas' disease in El Salvador.
AU - Cedillos, R. A.
JO - Bulletin of the Pan American Health Organization
JF - Bulletin of the Pan American Health Organization
Y1 - 1975///
VL - 9
IS - 2
SP - 135
EP - 141
SN - 0085-4638
AD - Cedillos, R. A.: Central America Research Station, Bureau of Tropical Diseases, US Public Health Service, c/o US Embassy, San Salvador, El Salvador.
N1 - Accession Number: 19750530014. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The occurrence of Chagas' disease (caused by Trypanosoma cruzi) in El Salvador, where the first known case was recorded in 1913, is reviewed, data being given on infection in man, in potential animal reservoirs and in Triatomines and on the proportion of houses infested with Triatomines in various communities. This ranged from 26.3% in a survey in 1957 to 100% in some rural areas investigated in 1964 and 1965. The rates of infection with T. cruzi were 0-65% in Triatoma dimidiata (Latr.), the predominant species at altitudes above 600 m, and those 13.6-47.1% in Rhodnius prolixus Stal, the predominant vector below 300 m. The rates of infection with Trypanosoma rangeli were 0-1.4% in Triatoma dimidiata and 5.3-11.4% in R. prolixus. Human infection with Trypanosoma cruzi was more prevalent in rural than in urban areas.
KW - Chagas' disease
KW - El Salvador
KW - Hemiptera
KW - man
KW - Reduviidae
KW - Rhodnius prolixus
KW - Triatoma dimidiata
KW - Trypanosoma cruzi
KW - Trypanosoma rangeli
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Heteroptera
KW - Hemiptera
KW - Rhodnius
KW - Triatominae
KW - Reduviidae
KW - Triatoma
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Salvador
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750530014&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of sulfur amino acid fortification of a food grade soy protein concentrate.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
AU - Adkins, J. S.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1975///
VL - 12
IS - 1
SP - 49
EP - 60
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19751435001. Publication Type: Journal Article. Language: English. Registry Number: 56-89-3, 63-68-3, 7727-37-9, 68-26-8. Subject Subsets: Human Nutrition
N2 - The effect of supplementing a soya bean concentrate with DL-methionine, L-cystine or DL-methionine hydroxy analogue (MHA) was studied at a 10% level of protein intake on groups of 10 weanling rats of bodyweight 45 to 50 g. Casein was used as reference protein. The rats were killed after 28 days; protein efficiency ratios (PER) were calculated and blood, livers, spleens, kidneys and testes were removed for analysis. The PER of the soya bean concentrate and casein were the same. Supplementing soya with 0.112 and 0.224% methionine progressively increased the PER; supplementation with MHA at a rate equivalent to 0.224% methionine was almost as effective. A supplement of 0.112% cystine was effective in the presence, but not in the absence, of methionine or MHA. It is concluded that the methionine-sparing action of cystine possibly holds also for MHA. Concentrations of N, RNA, DNA, vitamin A and total lipids in the liver increased with all supplements except cystine alone.
KW - amino acids
KW - cystine
KW - lipids
KW - liver
KW - methionine
KW - nitrogen
KW - nucleic acids
KW - nutritive value
KW - protein concentrates
KW - proteins
KW - RETINOL
KW - soyabeans
KW - SULFUR AMINO ACIDS
KW - supplements
KW - Glycine (Fabaceae)
KW - RATS
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - axerophthol
KW - lipins
KW - nutritional value
KW - nutritive value of soya bean protein concentrate
KW - quality for nutrition
KW - soya bean protein concentrate
KW - soybeans
KW - sulphur amino acids
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Human Nutrition (General) (VV100)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751435001&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of stored-food insects and other Alaskan insect pests.
AU - Gorham, J. R.
JO - Bulletin of the Entomological Society of America
JF - Bulletin of the Entomological Society of America
Y1 - 1975///
VL - 21
IS - 2
SP - 113
EP - 117
AD - Gorham, J. R.: Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19750529629. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - This survey of noxious arthropods occurring in Alaska includes a table, based on answers to a questionnaire, showing the occurrence of insect pests other than those infesting stored foods, and their tendency to be troublesome. The distribution and dispersal of these and other species of arthropods in Alaska are also discussed. Among the groups reported to occur are mosquitos, Ceratopogonids and Simuliids, which were stated to be either frequently or occasionally troublesome by more than 90% of those who reported them present in their answers. Wasps (Vespids), which are widespread, were regarded as at least occasionally troublesome by two-thirds of those reporting them present. Cockroaches and bedbugs [Cimex lectularius L.] were reported by a few people but never regarded as more than occasionally troublesome, but a quarter of the respondents reported body or head lice [Pediculus humanus humanus L. or P. h. capitis Deg.], and 6.2% of them considered that they were often troublesome and 62.5% that they were occasionally so.<new para>ADDITIONAL ABSTRACT:<new para>This paper, which is concerned with the noxious arthropods occurring in Alaska, includes a list, based on the literature and on unpublished data, of all the species recorded from stored foods of plant origin in Alaska. Large quantities of dry-packaged foods are sent to the State once a year by the United States Department of Agriculture and are widely used, among other purposes, for the preparation of school lunches. Information on the conditions under which these foods are stored and on the extent to which they are attacked by arthropods is included.
KW - agricultural entomology
KW - foods
KW - pests
KW - stored products
KW - taxonomy
KW - Alaska
KW - USA
KW - arthropods
KW - BLATTARIA
KW - Ceratopogonidae
KW - Cimex lectularius
KW - Culicidae
KW - man
KW - PEDICULUS CAPITIS
KW - Pediculus humanus
KW - Simuliidae
KW - Vespidae
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - Diptera
KW - Cimex
KW - Cimicidae
KW - Heteroptera
KW - Hemiptera
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - Hymenoptera
KW - Pediculus humanus
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bed bug
KW - blackflies
KW - Blattodea
KW - body louse
KW - buffalo gnats
KW - cockroaches
KW - head louse
KW - mosquitoes
KW - noxious arthropods
KW - Pediculus humanus capitis
KW - Pediculus humanus humanus
KW - systematics
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Biodeterioration (SS300)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750529629&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The detection and quantitative determination of ipomeamarone in damaged sweet potatoes (Ipomoea batatas).
AU - Wood, G.
AU - Huang, A.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1975///
VL - 23
IS - 2
SP - 239
EP - 241
SN - 0021-8561
AD - Wood, G.: Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19750732687. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Horticultural Science; Field Crops; Medical & Veterinary Mycology
KW - damage
KW - detection
KW - sweet potatoes
KW - tubers
KW - District of Columbia
KW - USA
KW - Ipomoea batatas
KW - Ipomoea
KW - Convolvulaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ipomeamarone
KW - ipomeamarone determination
KW - ipomeamarone in sweet potato
KW - United States of America
KW - Plant Composition (FF040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750732687&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The indirect hemagglutination test for malaria. Evaluation of antigens prepared from Plasmodium falciparum and Plasmodium vivax.
AU - Mathews, H. M.
AU - Fried, J. A.
AU - Kagan, I. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1975///
VL - 24
IS - 3
SP - 417
EP - 422
SN - 0002-9637
AD - Mathews, H. M.: Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500855. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Soluble antigens were prepared from Plasmodium falciparum and P. vivax and were evaluated in the indirect haemagglutination test. These antigens, attached to aldehydefixed type "O" erythrocytes, detected antibodies in more than 91% of infections with the homologous Plasmodium species. Detection rates in infections caused by the heterologous species ranged from 72% to 76%. Positive reactions occurred in less than 2% of sera from persons without malaria infection. [AS]
KW - immunology
KW - parasites
KW - man
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - antigen evaluation
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500855&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The seroepidemiology of malaria in Middle America. I. Longitudinal studies on populations in a low incidence area of El Salvador.
AU - Warren, M.
AU - Collins, W. E.
AU - Skinner, J. C.
AU - Larin, A. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1975///
VL - 24
IS - 5
SP - 740
EP - 748
SN - 0002-9637
AD - Warren, M.: Central America Res. Sta., Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, San Salvador, El Salvador.
N1 - Accession Number: 19762500958. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - 14 collections of serum samples in the village centres of 6 localities and one community in the Guayabo area of El Salvador were made from March 1970 to December 1971. 71 (5.5%) of 1,297 sera responded in the indirect fluorescent antibody test to at least one antigen at a level equal to or greater than 1:20. 31 had maximum endpoints to Plasmodium falciparum, 36 to P. vivax and 9 to P. malariae. Several serum specimens were positive to more than one species; in some there were equal maximum titres for more than one species. Positive serological responses as well as active cases found through "voluntary collaborator" posts occurred primarily in adult males, suggesting that much of the malaria in the study area resulted from exposure of this segment of the population in more malarious areas where they travelled to engage in temporary agricultural labour. The indirect fluorescent antibody test reflected the malaria in the population segments examined. Malaria incidence was generally low but transmission potential apparently varied markedly even over relatively small distances.
KW - parasites
KW - surveys
KW - El Salvador
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Haemosporida
KW - Salvador
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500958&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The seroepidemiology of malaria in Middle America. II. Studies on the Pacific Coast of Costa Rica.
AU - Warren, M.
AU - Collins, W. E.
AU - Jeffery, G. M.
AU - Skinner, J. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1975///
VL - 24
IS - 5
SP - 749
EP - 754
SN - 0002-9637
AD - Warren, M.: Central Americal Res. Sta., Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, San Salvador, El Salvador.
N1 - Accession Number: 19762500959. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Titres positive for malaria (1:20 or higher) by indirect immunofluorescence were seen in only 5 of 249 under 15-year-olds in 3 of 6 villages on the Pacific side of Costa Rica. Apparently active transmission is very low. Of 161 adults from these 3 villages, 44 were positive to one or more of the antigens. 29 of 189 adults were positive in the other 3 villages where none of 307 under 15 years old showed a titre of 1:20 or higher to any of the 3 malaria antigens tested (Plasmodium falciparum, P. vivax and P. malariae). It is suggested that the positive responses in the latter villages are more likely to be associated with old or imported cases than with current local transmission. Serological responses of 1:80 or higher to the P. falciparum antigen suggested the continued presence of this parasite in the population in spite of the paucity of positive blood smears with this species in recent years. Positive titres with the P. malariae antigen suggest that this parasite is probably still present in the area.
KW - epidemiology
KW - parasites
KW - surveys
KW - Costa Rica
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Threshold Countries
KW - Haemosporida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of the complement fixation, indirect immunofluorescence, and indirect haemagglutination tests for malaria.
AU - Wilson, M.
AU - Fife, E. H., Jr.
AU - Mathews, H. M.
AU - Sulzer, A. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1975///
VL - 24
IS - 5
SP - 755
EP - 759
SN - 0002-9637
AD - Wilson, M.: Parasit. Div., Center for Disease Control, Public Health Service, US Dept. of Health, Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500960. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - The complement fixation (CF), indirect immunofluorescence (IIF), and indirect haemagglutination (IHA) tests for malaria were compared by using sera from citizens of the USA with either natural infections or heroin-associated, needle-induced infections. In natural Plasmodium vivax infections, the CF, IIF, and IHA tests apparently detect malarial antibodies equally efficiently for the first 2 months after the onset of symptoms, but the titres obtained by CF and IIF rapidly decline within a year while the IHA titres remain elevated. In the sera from heroin addicts who developed needle-induced P. vivax infections, sensitivities of all 3 tests were decreased; the IIF and IHA tests each detected 83%, but the CF test detected only 57.1%. False-positive reactions with this group were very high for the CF (76.6%) and IHA (15.9%) tests, but only 2% for IIF. [AS]
KW - IMMUNODIAGNOSIS
KW - parasites
KW - USA
KW - man
KW - Plasmodium vivax
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - serological diagnosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500960&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation, identification, and biological characterization of Acanthamoeba polyphaga from a human eye.
AU - Visvesvara, G. S.
AU - Jones, D. B.
AU - Robinson, N. M.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1975///
VL - 24
IS - 5
SP - 784
EP - 790
SN - 0002-9637
AD - Visvesvara, G. S.: Parasit. Div., Center for Disease Control, Public Health Service, US Dep. of Health Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500966. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Trophozoites and cysts of an Acanthamoeba were repeatedly isolated from the corneal scrapings of a patient suffering from acute ulceration of the right eye. The amoeba was cloned and cultivated axenically in a proteose peptone-yeast extract-glucose medium and was identified as A. polyphaga on the basis of its morphology, especially that of the cysts. Experimental studies on its interactions in vitro with monkey kidney tissue culture (Vero line) and its pathogenicity to mice indicated that it was a low virulent strain. When large numbers (25,000+) were inoculated into Vero cell cultures, cytopathic effects were noticed within 5 to 6 days, consisting of cell shrinkage nuclear pycnosis and discontinuity of cell sheet, and the cell culture was totally destroyed in 8 to 10 days. When 20,000+ amoebae were instilled intranasally into each of 20 two-week-old mice, only one mouse died, on the 28th day. Amoebae were isolated from the brain of the dead mouse and trophozoites and cysts were also demonstrated in the brain sections. When amoebae isolated from the brain were intranasally instilled into mice, they failed to kill the mice for at least one month; however, when 10,000+ amoebae were inoculated intracerebrally, the mice died within 5 to 8 days, exhibiting symptoms of primary meningoencephalitis. [AS]
KW - culture
KW - parasites
KW - pathology
KW - USA
KW - West South Central States of USA
KW - Acanthamoeba polyphaga
KW - man
KW - MICE
KW - protozoa
KW - Rodents
KW - Acanthamoeba
KW - Acanthamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Muridae
KW - rodents
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southern States of USA
KW - USA
KW - isolation & identification
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500966&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nickel chloride-induced metabolic changes in the rat and guinea pig.
AU - Clary, J. J.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1975///
VL - 31
IS - 1
SP - 55
EP - 65
SN - 0041-008X
AD - Clary, J. J.: Toxicology Branch, National Inst. Occupational Safety and Health, Public Health Service, Dep. Health, Education, and Welfare, Cincinnati, Ohio 45202, USA.
N1 - Accession Number: 19751430720. Publication Type: Journal Article. Language: English. Registry Number: 7440-70-2, 57-88-5, 50-99-7, 9004-10-8, 7440-02-0, 7440-66-6. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - In male albino rats given 63NiCl2 solution intratracheally and male albino guineapigs given 63NiCl2 subcutaneously, tissue distribution of 63Ni, studied at intervals thereafter, indicated that in the guineapig retention of Ni in the pituitary was particularly high. In rats given a single intraperitoneal injection of NiCl2 there was a rapid transient increase in serum glucose, but a decrease in serum insulin and glycosuria. When exogenous insulin was given simultaneously with the Ni challenge, the increase in serum glucose was prevented. Studies in which rats were given 600 mg glucose-14C intragastrically and Ni intratracheally indicated that the mechanism of action of Ni was in the inhibition of insulin release which, it is suggested, could be related to concentration of Ni in the pituitary, increasing the release of pituitary hormones. Rats given drinking water containing 225 mg Ni/litre as NiCl2 for 4 months grew less, had lower serum triglyceride and cholesterol concentrations and excreted less total urine and Ca and Zn in urine than control rats given plain water to drink.
KW - blood
KW - calcium
KW - cholesterol
KW - effects
KW - glucose
KW - insulin
KW - metabolism
KW - nickel
KW - secretion
KW - sugar
KW - TRIACYLGLYCEROLS
KW - urine
KW - zinc
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - triglycerides
KW - urine volume
KW - Animal Nutrition (Physiology) (LL510)
KW - Physiology of Human Nutrition (VV120)
KW - Sugar and Sugar Products (QQ020)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751430720&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary modifications affecting the mutagenicity of N-nitroso compounds in the host-mediated assay.
AU - Zeiger, E.
JO - Cancer Research
JF - Cancer Research
Y1 - 1975///
VL - 35
IS - 7
SP - 1813
EP - 1818
AD - Zeiger, E.: Genetic Toxicology Branch, Division of Toxicology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19751436429. Publication Type: Journal Article. Language: English. Registry Number: 62-75-9. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Male Swiss albino mice weighing 25 to 35 g were given a stock diet, a complete semisynthetic diet, a protein-free diet or casein alone or were starved for 24 h. They were given dimethylnitrosamine (DMNA) 20, N-nitrosomorpholine (NM) 100 or N-methyl-N-nitrosourea (NMU) 10 mg/kg by muscle and mutagenicity for Salmonella typhimurium his G-46 was estimated by the method of Gabridge and Legator (Proceedings of the Society for Experimental Biology and Medicine (1969) 130, 831). The mutagenicity of DMNA and NM, which require metabolic activation for their biological activity, was less with the semisynthetic diet than in mice on the stock diet. DMNA mutagenicity was less with protein-free diet and more with casein than with the semisynthetic diet. NM mutagenicity was increased by starvation, but results for the protein-free and casein diets were ambiguous. For NMU, which does not require metabolic activation, mutagenicity was increased by the semisynthetic and protein-free diets and reduced by the casein diet.
KW - intake
KW - mutagenicity
KW - N-NITROSODIMETHYLAMINE
KW - nitroso compounds
KW - proteins
KW - bacteria
KW - MICE
KW - Salmonella
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - dimethylnitrosamine
KW - mutagenicity of Salmonella
KW - nitrosomorpholine
KW - nitrosourea
KW - protein intake by mouse host
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751436429&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The "new disease" status of human anisakiasis and North American cases: a review.
AU - Jackson, G. J.
JO - Journal of Milk and Food Technology
JF - Journal of Milk and Food Technology
Y1 - 1975///
VL - 38
IS - 12
SP - 769
EP - 773
AD - Jackson, G. J.: Div. of Microbiol., Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19760826843. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - An historical account is given of the recognition of human anisakiasis and the distribution of the disease is considered with reference to The Netherlands, Japan (from where the greatest numbers of cases have been reported) and North America. The public health implications of eating raw or under-cooked fish are discussed and the need for more information on the identity, life-cycles and pathogenicity of anisakines emphasised.
KW - case reports
KW - helminths
KW - history
KW - parasites
KW - North America
KW - Anisakidae
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - America
KW - nematodes
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760826843&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute-phase insulin secretion and glucose tolerance in young and aged normal men and diabetic patients.
AU - Palmer, J. P.
AU - Ensinck, J. W.
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
Y1 - 1975///
VL - 41
IS - 3
SP - 498
EP - 503
SN - 0021-972X
AD - Palmer, J. P.: Dep. Medicine, Univ. Washington, Diabetes Research Center, US Public Health Service Hospital, ZB-30 Seattle, Wash. 98195, USA.
N1 - Accession Number: 19761440341. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - Two groups each of 11 healthy men, aged 20 to 31 years and 65 to 88 years, were compared with each other and with a group of diabetic patients, aged 36 to 75 years, 6 men and 1 woman, not requiring insulin. After an overnight fast 20 g 50% glucose was given by vein and blood glucose and insulin were monitored. Mean fasting plasma glucose tended to be higher in the aged than in the young, 107 and 94 mg/100 ml. Comparison of the glucose disposal rate clearly separated the 2 populations, although the acute phase of insulin secretion, within the first 5 min after glucose, was similar. The 7 diabetics had fasting blood glucose >140 mg/100 ml, impaired insulin release and slow glucose disposal.
KW - diabetes
KW - glucose tolerance
KW - insulin secretion
KW - old age
KW - blood sugar tolerance
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761440341&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of the diphosphonate EHDP on bone mineral metabolism during prolonged bed rest.
AU - Lockwood, D. R.
AU - Vogel, J. M.
AU - Schneider, V. S.
AU - Hulley, S. B.
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
Y1 - 1975///
VL - 41
IS - 3
SP - 533
EP - 541
SN - 0021-972X
AD - Lockwood, D. R.: Metabolic Unit, Dep. Medicine, US Public Health Service Hospital, San Francisco, Calif. 94118, USA.
N1 - Accession Number: 19761440344. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - The effect of disodium ethane-1-hydroxy-1,1-diphosphonate on bone mineral metabolism was tested in 4 healthy young men during 20 weeks of continuous bed rest. Two subjects received a daily oral dose of 5 mg/kg and the other 2 had 20 mg/kg. The low dose had 2 minor effects: the increase in bone accretion rate which usually occurs during bed rest was prevented, and there was an accentuation of the rest-induced increase in hydroxyproline excretion. Skeletal mineral loss, assessed by Ca balance measurements and gamma ray absorptiometry of the calcaneus, occurred at the rate previously noted in untreated control subjects.Two types of drug effect were apparent at the higher dosage: one was immediate and sustained, a rise in serum P concentration and a fall in serum alkaline phosphatase activity. The other was delayed and progressive, a decline in urinary hydroxyproline excretion and in the rates of bone accretion and resorption. Skeletal mineral loss may have been affected; the usual negative mineral balance developed during the first half of the study, then disappeared during the last few weeks. However, gamma-ray absorptiometry revealed no attenuation of the calcaneal mineral losses.
KW - bed rest
KW - bones
KW - mineral metabolism
KW - diphosphonate
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761440344&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of potassium depletion in normal males: an Apollo 15 simulation.
AU - Hyatt, K. H.
AU - Johnson, P. C.
AU - Hoffler, G. W.
AU - Rambaut, P. C.
AU - Rummel, J. A.
AU - Hulley, S. B.
AU - Vogel, J. M.
AU - Huntoon, C.
AU - Spears, C. P.
JO - Aviation, Space, and Environmental Medicine
JF - Aviation, Space, and Environmental Medicine
Y1 - 1975///
VL - 46
IS - 1
SP - 11
EP - 15
SN - 0095-6562
AD - Hyatt, K. H.: US Public Health Service Hospital, San Francisco, Calif. 94118, USA.
N1 - Accession Number: 19751432016. Publication Type: Journal Article. Language: English. Registry Number: 7440-09-7. Subject Subsets: Human Nutrition
N2 - Before the study and during equilibration and control periods 2 men took vigorous daily exercise. A 9-day equilibration (E) period, a 7-day control (C) period, a 12-day bedrest (B) period and a 4-day recovery (R) period simulated a space flight. The study diet was the same throughout except for the variation in K content. K was reduced from 125 m-equiv/day during E, C and R to 15 m-equiv/day during B. Urine, faeces and sweat were collected. Electrocardiograph (ECG) recordings were made throughout B and during 24-h periods in C and R. Muscle strength was tested periodically. Both men were in negative K balance throughout B, and serum K values were lower at day 12 than at day 1 of B. The Na balance remained positive in both subjects throughout B. The first man showed no alteration in ECG taken on day 7 of C and day 12 of B, but the second who had sustained a much greater K loss showed prominent U waves and unspecific T-wave changes by day 12 of B. Estimations of maximum oxygen uptake showed that neither subject had returned to C status by day 15 of R. There was no significant loss of muscle strength during the study.
KW - depletion
KW - potassium
KW - space flight
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - potassium depletion, man
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751432016&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Social class differences among patients with large-bowel cancer in Cali, Colombia.
AU - Haenszel, W.
AU - Correa, P.
AU - Cuello, C.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1975///
VL - 54
IS - 5
SP - 1031
EP - 1035
SN - 0027-8874
AD - Haenszel, W.: Biometry Branch, National Cancer Inst., Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19751438488. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The incidence of large-bowel cancer in Cali, Colombia, for 1962-71 shows the upper socioeconomic classes to be at higher risk. This is the first report of a socioeconomic gradient in risk for this site. The gradients were sharpest for cancer of the ascending and rectosigmoid colon and were slight for cancer of the caecum and rectum. The Cali experience presents several parallels with information derived from comparisons of developed and developing countries and also appears consistent with recent information on the possible role of dietary factors in bowel cancer.
KW - incidence
KW - large intestine
KW - neoplasms
KW - populations
KW - surveys
KW - Colombia
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - cancers
KW - disorders
KW - large-bowel cancer
KW - socioeconomic variation
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751438488&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tryptophanase of fecal flora as a possible factor in the etiology of colon cancer.
AU - Chung, K. T.
AU - Fulk, G. E.
AU - Slein, M. W.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1975///
VL - 54
IS - 5
SP - 1073
EP - 1078
SN - 0027-8874
AD - Chung, K. T.: Frederick Cancer Research Center, National Cancer Inst., Public Health Service, US Dep. Health, Education, and Welfare, Frederick, Md. 21701, USA.
N1 - Accession Number: 19751438489. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Indole production from tryptophan was tested with 23 strains of intestinal aerobes from 2 laboratories. Three isolates of Bacteroides fragilis thetaiotamicron and one Citrobacter sp. were indole positive. The tryptophanase activity of the indole-positive strains was inducible by tryptophan and inhibited by glucose. Dialysed freshly prepared extracts showed that indole formation was a direct result of tryptophan degradation. Tryptophan concentration and tryptophanase activity in faeces from rats on an all-meat diet were significantly higher than from rats on a normal diet. The higher tryptophanase activity was due to enzyme induction by tryptophan and not a result of an inhibitor in the faeces of normally fed rats. The results suggest there is a higher exposure to carcinogens such as indole and tryptophan metabolites in populations eating a diet rich in meat and this agrees with epidemiological data on colon cancer development in man.
KW - aetiology
KW - colon
KW - faeces
KW - neoplasms
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - causal agents
KW - etiology
KW - feces
KW - relation to colon cancer etiology
KW - relation to tryptophanase in faeces
KW - tryptophanase
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19751438489&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trimming as a means of removing patulin from fungus-rotted apples.
AU - Lovett, J.
AU - Thompson, R. G., Jr.
AU - Boutin, B. K.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1975///
VL - 58
IS - 5
SP - 909
EP - 911
AD - Lovett, J.: Division of Microbiology, Food and Drug Administration, Cincinnati, Ohio, USA.
N1 - Accession Number: 19750336834. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 149-29-1. Subject Subsets: Animal Nutrition; Human Nutrition; Horticultural Science; Medical & Veterinary Mycology
N2 - Penicillium expansum 1071, 1172, NRLL 973, and P. patulum ATCC 24550 were inoculated into Red Delicious, Golden Delicious, and McIntosh apples. The decayed tissue was trimmed from the sound tissue, each fraction was weighed and the patulin concentration in the juice was assayed by thin layer chromatography. The patulin content ranged from 140 to 4880 mu g/apple. Trimming removed 93-99% of the total patulin, regardless of incubation temperature, fungus strain, or apple cv.
KW - aflatoxins
KW - apples
KW - control
KW - diseases
KW - fruit crops
KW - mycotoxins
KW - patulin
KW - production
KW - storage
KW - temperate fruits
KW - Malus
KW - Penicillium expansum
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Penicillium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - carcinogenic
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - Penicillium expansum patulin
KW - Penicillium patulum
KW - removal by trimming
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750336834&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Imported African trypanosomiasis in the United States.
AU - Spencer, H. C.
AU - Gibson, J. J., Jr.
AU - Brodsky, R. E.
AU - Schultz, M. G.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1975///
VL - 82
IS - 5
SP - 633
EP - 638
SN - 0003-4819
AD - Spencer, H. C.: Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19772504374. Publication Type: Journal Article. Language: English. Subject Subsets: Leisure, Recreation, Tourism; Protozoology
N2 - Since 1967, 5 cases of Trypanosoma rhodesiense infection in Americans and one case of T. gambiense in an African student have been diagnosed and treated in the USA. 3 of the former infections had been acquired in Botswana, one during a one-day trip to the Kagera Game Park, Rwanda, and the other probably in the Serengeti Park. The T. gambiense infection was acquired in Liberia. Diagnosis was delayed although signs and symptoms were typical. All responded to treatment (suramin sodium and/or melarsoprol) but the T. gambiense patient relapsed. Although the risk of travellers acquiring the disease is small, it is necessary for physicians to be cognisant of the possibility of exotic infections.
KW - infections
KW - parasites
KW - travel
KW - USA
KW - man
KW - protozoa
KW - Trypanosoma gambiense
KW - Trypanosoma rhodesiense
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19772504374&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of excess vitamin E on vitamin A toxicity in rats.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1975///
VL - 105
IS - 12
SP - 1600
EP - 1606
SN - 0022-3166
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761440875. Publication Type: Journal Article. Language: English. Registry Number: 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition; Veterinary Science
N2 - Male Holtzman rats (78 g) were fed on semipurified 16%-protein diets for 8 weeks, with a food grade soya bean protein concentrate as protein source. The basal diet contained added DL-methionine (0.26%) and adequate amounts of vitamins A (14 535 IU/kg as retinyl acetate) and E (60 IU/kg as DL- alpha -tocopheryl acetate) and all other required nutrients. Experimental diets included: basal + vitamin E 600 IU/kg; basal + vitamin E 6000 IU/kg; basal + vitamin A 2.9 X 106 IU/kg; basal + vitamin A 2.9 X 106 IU + vitamin E 600 IU/kg; and basal + vitamin A 2.9 X 106 IU + vitamin E 6000 IU/kg. Both vitamin A and vitamin E had significant effects on growth. There was an increase in growth with vitamin E intake and a decrease in growth with excess vitamin A. The net result of the 2 effects was that groups given both vitamins tended to be quite close in mean values to the group on basal diet. Vitamin A significantly increased relative weights of spleen and testes; vitamin E reduced that effect and also reduced significantly relative adrenal weight, whereas vitamin A significantly increased it. The 2 effects tend to cancel each other in the sense that the groups given both vitamins had an average relative adrenal weight quite close to that of the group on basal diet. But vitamin A still had an effect even when 6000 IU vitamin E was given. Interaction of the vitamins was significant for plasma total protein and liver vitamin A. There was an increase in liver vitamin A with increasing vitamin E in the diet. Blood urea N and plasma cholesterol were unchanged. A significant interaction of vitamins A and E affected plasma total protein, liver vitamin A and relative weight of spleen and testes.
KW - adrenal glands
KW - Poisoning
KW - RETINOL
KW - Spleen
KW - testes
KW - Toxicology
KW - vitamin E
KW - Vitamins
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adrenals
KW - axerophthol
KW - interaction with vitamin A
KW - interaction with vitamin E
KW - testicles
KW - toxicosis
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761440875&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An epizootic of bovine cysticercosis.
AU - Slonka, G. F.
AU - Moulthrop, J. I.
AU - Dewhirst, L. W.
AU - Hotchkiss, P. M.
AU - Vallaza, B.
AU - Schultz, M. G.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1975///
VL - 166
IS - 7
SP - 678
EP - 681
SN - 0003-1488
AD - Slonka, G. F.: Center for Disease Control, Public Health Service, US Dept. of Health, Education & Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19750818957. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science; Veterinary Science
N2 - In March 1973 an increased incidence of bovine cysticerciasis was reported from a large feedlot near Phoenix, Arizona, USA. Approximately 10% of the cattle sent for slaughter from January to April of that year were infected with Taenia saginata cysticerci, compared with less than 1% the previous year. The likely source of infection was an employee at the feed mill who admitted defecating in the fields. He was found to carry the adult tapeworm. Recommendations for the prevention of similar outbreaks of bovine cysticerciasis are given.
KW - cysticercosis
KW - helminths
KW - outbreaks
KW - parasites
KW - zoonoses
KW - Mountain States of USA
KW - USA
KW - cattle
KW - Cestoda
KW - Man
KW - TAENIA
KW - Taenia saginata
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Platyhelminthes
KW - invertebrates
KW - Homo
KW - Hominidae
KW - Primates
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Taenia
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Cyclophyllidea
KW - Cysticercus
KW - parasitic worms
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750818957&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of salmonellae in foodstuffs [including dried skim-milk], feces, and water by immunofluorescence.
AU - Cherry, W. B.
AU - Thomason, B. M.
AU - Gladden, J. B.
AU - Holsing, N.
AU - Murlin, A. M.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1975///
VL - 254
SP - 350
EP - 368
SN - 0077-8923
AD - Cherry, W. B.: Center for Disease Control, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19750420533. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition; Dairy Science; Veterinary Science
KW - detection
KW - dried skim milk
KW - Faeces
KW - Food microbiology
KW - IMMUNOFLUORESCENCE
KW - Meat inspection
KW - reviews
KW - techniques
KW - Water pollution
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - dried skim-milk
KW - feces
KW - fluorescent antibody technique
KW - IFAT
KW - nonfat dry milk
KW - salmonellae
KW - Techniques and Methodology (ZZ900)
KW - Meat Produce (QQ030)
KW - Food Composition and Quality (QQ500)
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19750420533&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protective effects of ascorbic acid against toxicity of heavy metals.
AU - Fox, M. R. S.
A2 - King, C. G.
A2 - Burns, J. J.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1975///
VL - 258
SP - 144
EP - 150
SN - 0077-8923
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761445140. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
N2 - Toxicity of Cd in young Japanese quail rapidly produced moderate growth depression, hypogonadism in the male, decreased bone ash, severe anaemia, alterations of "indicator" tissue levels of several essential inorganic elements, and histological abnormalities of the duodenum, bone marrow, adrenal medulla, and oesophageal mucous glands. Cd appears to have direct effects on Zn and Fe, particularly ferric Fe, by decreasing their intestinal absorption. Small amounts of dietary ascorbic acid were protective against many of the adverse effects of Cd. The experience with Cd may be useful in studies of the effects of ascorbic acid on the toxicity of other metals.
KW - cadmium
KW - poultry
KW - toxicity
KW - Japanese quails
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ascorbic acid protection
KW - domesticated birds
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761445140&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin C and upper respiratory illness in Navaho children: preliminary observations (1974).
AU - Coulehan, J. L.
AU - Kapner, L.
AU - Eberhard, S.
AU - Taylor, F. H.
AU - Rogers, K. D.
A2 - King, C. G.
A2 - Burns, J. J.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1975///
VL - 258
SP - 513
EP - 522
SN - 0077-8923
AD - Coulehan, J. L.: US Public Health Service, Fort Defiance Indian Hospital, Fort Defiance, Ariz. 86504, USA.
N1 - Accession Number: 19761445177. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7. Subject Subsets: Human Nutrition
N2 - In a double-blind study 870 Navaho children 6 to 15 years old in 2 Arizona elementary schools were given two 500-mg ascorbic acid or citric acid placebo tablets daily for 15 or 18 weeks. Absences were higher than in a previous survey (NAR 45, 1292) and children given ascorbic acid were absent more often than children given placebo. Within each school there was no consistent difference between the groups in incidence of cold symptoms, including catarrh and less specific symptoms, but incidence of side effects such as abdominal pain, diarrhoea and skin sores was significantly higher in one school, indicating that those children were more prone to acknowledge symptoms than children at the other school. There were significantly fewer 'sick days' in which one or more symptoms were present among younger children given vitamin C, but the difference was slight and constrasted with more, though not significantly, frequent sick days among older children given vitamin C. When individual symptoms and sick days were analysed by sex, age and time intervals within the study, there was no consistent pattern indicative of a positive clinical effect of 1-g ascorbic acid supplements.
KW - ascorbic acid
KW - children
KW - prophylaxis
KW - respiratory diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - vitamin C
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761445177&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The occurrence and control of mycotoxins and mycotoxicoses.
AU - Rodricks, J. V.
JO - Food and Nutrition (FAO)
JF - Food and Nutrition (FAO)
Y1 - 1976///
VL - 2
IS - 1
SP - 9
EP - 14
AD - Rodricks, J. V.: Research Management, Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19761450661. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A short review lists some important mycotoxins, toxicoses of man and animals, the associated foods and some mycotoxins found in food for which the risk to health of man is uncertain or unknown.
KW - mycotoxins
KW - fungal toxins
KW - occurrence and control
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761450661&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The crab louse - review of physiology and study of anatomy as seen by the scanning electron microscope.
AU - Kraus, S. J.
AU - Glassman, L. H.
JO - Journal of the American Venereal Disease Association
JF - Journal of the American Venereal Disease Association
Y1 - 1976///
VL - 2
IS - 4
SP - 12
EP - 18
AD - Kraus, S. J.: Center for Disease Control, Public Health Service, US DHEW, Atlanta, Georgia, USA.
N1 - Accession Number: 19770547256. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Since effective control of a parasitic infestation is aided by a thorough understanding of the parasite and its interaction with the host, the external anatomy of Phthirus pubis (L.) and its egg were studied by scanning electron microscopy, and the structures observed were reviewed from earlier work in order to determine their biological function. The pathophysiology of the insect-host interaction and current treatment recommendations are also reviewed from recent literature.
KW - anatomy
KW - chemical control
KW - control
KW - ectoparasitoses
KW - insect control
KW - physiology
KW - Anoplura
KW - man
KW - Phthiraptera
KW - Pthirus
KW - Pthirus pubis
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pthirus
KW - Pthiridae
KW - Anoplura
KW - crab louse
KW - Phthirus
KW - Phthirus pubis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770547256&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Insects as food.
AU - Gorham, J. R.
JO - Bulletin of the Society of Vector Ecologists
JF - Bulletin of the Society of Vector Ecologists
Y1 - 1976///
VL - 3
SP - 11
EP - 16
AD - Gorham, J. R.: US Public Health Service, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19780556246. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology
N2 - The consumption of insects by man is discussed with reference to cultural and ecological considerations, health hazards, the deliberate or accidental nature of the insect consumption, and the relative safety of different methods of preparation of insects, insect-damaged or insect-infested food. Attention is drawn to the fact that many phytophagous insects are more efficient primary consumers (in terms of energy efficiency and protein production per energy unit) than are the traditional wild or domestic meat animals. In view of the growing world demand for food and the need to find new food sources and to minimise wastage, even of damaged foods, further study on the safety of insects and insect-damaged products for human consumption is essential; it is important however to distinguish between insects, insect-damaged and insect-infested foods that are safely and deliberately produced, processed and preserved as human food, and those that represent lapses in sanitation during some stage of food production. This distinction may be implemented by judicious enforcement of the Federal Food, Drug and Cosmetic Act. Possible future increase in the amount of insect-derived material tolerated or deliberately included in food might necessitate a more precise quality grading and statements on the labels or packaging of the proportion of insect material or damage present.
KW - agricultural entomology
KW - food
KW - insects
KW - man
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - insects eaten
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780556246&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Information bearing on the evaluation of the hazard to man from aflatoxin ingestion.
AU - Stoloff, L.
AU - Friedman, L.
JO - PAG Bulletin
JF - PAG Bulletin
Y1 - 1976///
VL - 6
IS - 2
SP - 21
EP - 32
AD - Stoloff, L.: Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761451639. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Nine questions were asked and the answers, summarized from published work, are as follows. Fischer rats are very sensitive to aflatoxin carcinogenesis, compared with USC or Wistar rats. Mice resist aflatoxin doses in feed that would cause tumours in Fischer rats, but intraperitoneal doses equivalent to 20/106 feed caused hepatoma in newborn mice; monkeys given aflatoxin by intramuscular injection then for several years in drinking water developed tumours not typical of those in rats given aflatoxin in diet. Not only liver but also kidneys, colon, lachrymal glands and possibly lungs can be the site of aflatoxin-induced tumour. Malformations were induced in young of hamsters but not of rats or mice given a single high dose intraperitoneally, and young of rats given high doses in diet during pregnancy included none born malformed but many had liver tumours or other liver lesions. There was good inferential evidence that one or more liver metabolites of aflatoxin B1 acted as carcinogen in rats. Trials in vitro showed difference in rate and pattern of aflatoxin metabolism by liver of different species, which might be related to aflatoxin carcinogenesis; liver of man differed from that of rats and most nearly resembled that of monkeys. There was a positive relation between aflatoxin intake and incidence of liver cancer in human populations with high incidence, but there was no basis for concluding that aflatoxin was the cause; assuming aflatoxin to be the cause, a population with average aflatoxin B1 0.12/109 in food had a very low risk of liver cancer. Populations could have been exposed to other liver carcinogens such as pyrrolizidine alkaloids or Se compounds, or to alcohol. There was a negative relation between exposure to aflatoxin and incidence of liver, colon or kidney cancer in USA, but there may have been other etiological factors complicating the relation.
KW - aflatoxins
KW - laboratory animals
KW - mycotoxins
KW - poisoning
KW - reviews
KW - toxicity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - evaluation of relevant data
KW - fungal toxins
KW - toxicosis
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761451639&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition counseling and children's dental health.
AU - Robinson, L. G.
AU - Paulbitski, A.
AU - Jones, A.
AU - Roberts, M.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1976///
VL - 8
IS - 1
SP - 33
EP - 34
SN - 0022-3182
AD - Robinson, L. G.: Dietic Dep., Public Health Service Hospital, 15th Ave. and Lake St., San Francisco, CA 94118, USA.
N1 - Accession Number: 19761443660. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A nutrition counselling programme for children in the cavity-prone age groups 5 to 8 and 12 to 16 years old was developed in 1973 by the Dietetic and Dental Departments of the Public Health Service Hospital in San Francisco. The programme consists of at least 3 visits to the Nutrition Clinic by the parent and child. At the time of the dental appointment, the dental auxiliaries counsel child and parents in oral hygiene. The parent and child are then directed to the Nutrition Clinic for a 30-min counselling session. The dietitian elicits a 24-h dietary recall from the child which is used as a teaching tool on how to keep records. The child is then recommended to keep a 3-day food record (including 1 weekend day) helped by the parent. This record is returned at the second visit, made in conjunction with the next dental appointment. At the second visit, which lasts about 60 min, the dietitian uses the 3-day record to calculate the total number of sugar-containing foods eaten. The total number of exposures to sugar is multiplied by 20 min to show the patient the total number of clock minutes the teeth are subjected to plaque-forming bacteria. The child's daily nutrient intake is calculated, compared with the recommended dietary allowances and suggestions for improvement are made if necessary. The parent and child are asked to complete a second 3-day food record. This is later evaluated and compared with the first food record for adherence to the recommendations. Audio-visual aid material on dental and nutrition information is also provided. To date, about 80 families with children from 2 to 16 years old have been counselled.
KW - children
KW - nutrition education
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dental caries prevention
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761443660&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of chronic oral administration of erythrosine in the Mongolian gerbil.
AU - Collins, T. F. X.
AU - Long, E. L.
JO - Food and Cosmetic Toxicology
JF - Food and Cosmetic Toxicology
Y1 - 1976///
VL - 14
IS - 4
SP - 233
EP - 248
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761449769. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - For 105 weeks Mongolian gerbils (Meriones unguiculatus) were given a diet without or with the food dye erythrosine 1, 2 or 4% or for 97 weeks erythrosine by stomach tube twice weekly as an aqueous solution to supply 200, 750 or 900 mg/kg. In those given erythrosine in the diet, haematocrit, leucocyte count, reticulocyte count and Hb value all fell; there was a dose-related loss in weight. There were also dose-related changes in the thyroid characterized by enlargement, with increased storage of colloid, of a majority of the follicles, associated with less prominent but consistent foci of small follicles and, in a few gerbils, focal hyperplasia and intraluminal and interstitial leucocytic infiltration. Although there was a slight increase in follicular size in the thyroids of gerbils given 900 and 750 mg/kg by tube, there was no definite effect similar to that in the diet study. In both studies there was more granulomatosis of the liver in control than in treated gerbils.
KW - dyes
KW - toxicity
KW - MERIONES UNGUICULATUS
KW - Meriones
KW - Gerbillinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dyestuffs
KW - erythrosine toxicity
KW - Mongolian gerbil
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761449769&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative determination of zinc, iron, calcium, and phosphorus in the total diet market basket by atomic absorption and colorimetric spectrophotometry.
AU - McGary, E. D.
AU - Young, B. E.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1976///
VL - 24
IS - 3
SP - 539
EP - 542
SN - 0021-8561
AD - McGary, E. D.: Food and Drug Administration, 1009 Cherry Street, Kansas City, Mo. 64106, USA.
N1 - Accession Number: 19771446397. Publication Type: Journal Article. Language: English. Registry Number: 7723-14-0, 7440-70-2, 7439-89-6, 7440-66-6. Subject Subsets: Human Nutrition
N2 - The dry ash official AOAC method with a new minor modifications was applied. Zn and Fe were estimated by atomic absorption spectrophotometry (AAS) in ash diluted with 0.1 N HCl, Ca by AAS after a second series of dilutions and addition of La, and P colorimetrically in a third series of dilutions from the original. Recoveries from diet samples were 94 to 99% on average.
KW - calcium
KW - chemical composition
KW - composition
KW - estimation
KW - foods
KW - iron
KW - phosphorus
KW - zinc
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771446397&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malarial antibodies measured by the indirect hemagglutination test in West African children.
AU - Mathews, H. M.
AU - Lobel, H. O.
AU - Breman, J. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 2
SP - 217
EP - 220
SN - 0002-9637
AD - Mathews, H. M.: Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500314. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - The indirect hemagglutination test with Plasmodium falciparum antigen was used to measure malarial antibodies in filter paper blood specimens from 527 West African children. A slight decline in antibodies was noted in 6- to 8-month-old children who had no malaria parasites in their blood smears. Children older than 10 months had similar antibody levels regardless of the presence or absence of demonstrated parasites in blood smears. [AS].
KW - diagnosis
KW - haemagglutination tests
KW - IMMUNODIAGNOSIS
KW - parasites
KW - West Africa
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Africa South of Sahara
KW - Africa
KW - hemagglutination tests
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500314&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasmodium brasilianum antigen for use in the indirect hemagglutination test.
AU - Mathews, H. M.
AU - Dilworth, D. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 2
SP - 351
EP - 352
SN - 0002-9637
AD - Mathews, H. M.: Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500313. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Antigen of Plasmodium brasilianum was attached to human erythrocytes and used for indirect haemagglutination tests. At dilutions of 1/16 or greater it reacted with no sera from uninfected persons, 85% of sera from P. malariae infections, 83% of P. vivax, 70% of P. falciparum and 70% of P. ovale infections.
KW - antigens
KW - immunology
KW - parasites
KW - Plasmodium brasilianum
KW - Plasmodium falciparum
KW - Plasmodium malariae
KW - Plasmodium ovale
KW - Plasmodium vivax
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antigenicity
KW - HATI for malaria
KW - immunogens
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500313&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malaria control in the twentieth century.
AU - Jeffery, G. M.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 3
SP - 361
EP - 371
SN - 0002-9637
AD - Jeffery, G. M.: Bureau of Trop. Dis., Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500361. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - [General account of recent progress in malaria control].
KW - chemical control
KW - control
KW - insect control
KW - malaria
KW - mosquito nets
KW - parasites
KW - reviews
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - Plasmodium
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - general account
KW - Haemosporida
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500361&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A case of asymptomatic babesiosis in Georgia.
AU - Healy, G. R.
AU - Walzer, P. D.
AU - Sulzer, A. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 3
SP - 376
EP - 378
SN - 0002-9637
AD - Healy, G. R.: Center for Disease Control, Public Health Service, US Dep. of Health, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19762500372. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - A black male resident of Georgia, USA, was asymptomatic when organisms later identified as Babesia sp. were found in his blood-films. This is the 7th reported case of human piroplasmosis and the first in which the patient was asymptomatic.
KW - case reports
KW - parasites
KW - South Atlantic States of USA
KW - USA
KW - Babesia
KW - man
KW - protozoa
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500372&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of Ascaris infection on nutritional status in children.
AU - Blumenthal, D. S.
AU - Schultz, M. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 5
SP - 682
EP - 690
SN - 0002-9637
AD - Blumenthal, D. S.: Parasitic Diseases and Veterinary Public Health Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19771453833. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition; Helminthology
N2 - Stool samples were obtained from 193 children in Louisiana and the stool sediment was examined for Ascaris infestation; 30 Ascaris-infected children were then matched on the basis of sex, age and monthly family income with 30 uninfected children. Nutritional and socio-economic status was assessed and each child had a dietary interview. Height, weight and clinical details were recorded. The socio-economic status of both groups was similar, the children mainly coming from large low-income families. For most of the children the intake of dairy products, fruit, vegetables and meat was inadequate but bread and cereal consumption was adequate. Weight for height measurement was the only index which was affected by Ascaris infection but the differences were not significant. It was concluded that Ascaris infection produced only a slight adverse effect on plasma vitamin C and serum protein values in the host but no nutritional deficiency resulted.<new para>ADDITIONAL ABSTRACT:<new para>The nutritional status of 30 children in Louisiana, USA, infected with Ascaris lumbricoides was compared with that of 30 uninfected controls matched for age, race, sex and family income. Statistically significant evidence of an adverse effect of infection on serum albumin levels and plasma vitamin C levels was found, but no child had inadequate levels of these nutrients. Suggestive evidence of an adverse effect of the infection on weight for height and on riboflavin nutriture was also found. No manifest nutritional deficiency could be shown to have resulted from the infection, but it is pointed out that these children enjoyed a relatively substantial food supply.
KW - children
KW - helminths
KW - hosts
KW - nematode infections
KW - nutrition
KW - nutritional state
KW - parasites
KW - pathogenicity
KW - USA
KW - West South Central States of USA
KW - Ascaris
KW - Ascaris lumbricoides
KW - man
KW - Ascarididae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascaris
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southern States of USA
KW - USA
KW - Ascaridida
KW - nematodes
KW - nutritional status
KW - parasitic worms
KW - Secernentea
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771453833&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Autochthonous dermal leishmaniasis in Texas.
AU - Shaw, P. K.
AU - Quigg, L. T.
AU - Allain, D. S.
AU - Juranek, D. D.
AU - Healy, G. R.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 6
SP - 788
EP - 796
SN - 0002-9637
AD - Shaw, P. K.: Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19772502172. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - In 1972, a case of dermal leishmaniasis was recognized in a 74-year-old woman in Gonzales County and, in 1974, another case was found in a 56-year-old man in Karnes County, Texas, USA. Both were positive by biopsy and culture and the 2nd also by immunodiagnosis. There was no epidemiological association between the 2 cases. The infections were probably acquired locally in southern Texas. Serological evidence of Leishmania infection was found in a neighbour of the 2nd case and in 3 dogs living nearby. Potential sylvatic reservoirs and arthropod vectors are present in the area.
KW - case reports
KW - leishmaniasis
KW - mucocutaneous leishmaniasis
KW - parasites
KW - Texas
KW - USA
KW - West South Central States of USA
KW - Diptera
KW - Leishmania
KW - man
KW - Phlebotominae
KW - protozoa
KW - Psychodidae
KW - SARCOMASTIGOPHORA
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Psychodidae
KW - Diptera
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - espundia
KW - leishmaniosis
KW - Mastigophora
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19772502172&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A modification of a formol-ether concentration technique for increased sensitivity in detecting Schistosoma mansoni eggs.
AU - Knight, W. B.
AU - Hiatt, R. A.
AU - Cline, B. L.
AU - Ritchie, L. S.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1976///
VL - 25
IS - 6
SP - 818
EP - 823
SN - 0002-9637
AD - Knight, W. B.: An Juan Lab., Bureau of Lab., Center for Disease Control, Public Health Service, U.S. Dep . of Health, Education and Welfare, San Juan, Puerto Rico 00936, West Indies.
N1 - Accession Number: 19770831996. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - Modification of the formol-ether concentration technique by initial measurement of an exact quantity of faeces, the use of a stainless steel sieve instead of gauze, the addition of a 2nd sieve, the use of Triton as a wetting agent, and the addition of a 2nd washing step before the concentration step and a final sedimentation step, made it more sensitive in terms of number of Schistosoma mansoni eggs counted. The sediment was smaller and clearer and needed about 15% less time to examine. It was more successful than the Kato technique in detecting light infections, although at higher levels of infection, when expressed on an e.p.g. basis, the thick smear method detected relatively more eggs. The reproducibility of the modified concentration technqiue compared well with that of the thick smear test.
KW - detection
KW - helminths
KW - ova
KW - parasites
KW - techniques
KW - Schistosoma
KW - Schistosoma mansoni
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - modified formyl-ether concentration
KW - parasitic worms
KW - parasitolog
KW - Strigeida
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preliminary clinical and anthropometric findings from the first Health and Nutrition Examination Survey, USA, 1971-1972.
AU - Lowenstein, F. W.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1976///
VL - 29
IS - 8
SP - 918
EP - 927
SN - 0002-9165
AD - Lowenstein, F. W.: US Public Health Service, Health Resources Administration, National Center for Health Statistics, Division of Health examination statistics, Rockville, Md. 20852, USA.
N1 - Accession Number: 19761449857. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - In a sample of 10 126 persons designed to represent the total US population, 8% of negroes between the ages of 45 and 59 had hepatomegaly. Tongue signs and absent knee and angle jerks were more prevalent in negroes aged 45 to 74; they also had lower urinary excretion of thiamin and riboflavin than whites. Bowed legs and knock knees were more frequent in negroes aged 1 to 17 and negro women 18 to 44. Prevalence of bleeding, swollen gums was highest in negroes aged 45 to 59. Both grade I and II goitre were more prevalent in negroes at all ages except men of 18 to 59. Chvostek's sign, indicating possible Ca deficiency, was more frequent in negroes at all ages with 2 exceptions. Major anthropometric findings are presented.
KW - nutritional state
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional status
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761449857&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of large daily doses of ascorbic acid on pregnancy in guinea pigs, rats, and hamsters.
AU - Alleva, F. R.
AU - Alleva, J. J.
AU - Balazs, T.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1976///
VL - 35
IS - 2
SP - 393
EP - 395
SN - 0041-008X
AD - Alleva, F. R.: Division of Drug Biology, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761445339. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 50-81-7. Subject Subsets: Human Nutrition; Veterinary Science
N2 - Ascorbic acid 400 mg/kg day was given to 24 female guineapigs aged 4 months, from up to 3 weeks before conception or from about the 23rd day of gestation until the 50th day, and their reproductive performance was compared with that of a similar number of controls given equal amounts of saline. Daily doses of ascorbic acid 50, 150 or 450 mg/kg were given to groups of 11 female Holtzmann rats aged 3 months from day 1 to 19 of pregnancy, and Lakeview hamsters aged 2 months had similar doses from day 1 to 15 of pregnancy; controls received equal amounts of deionized water. No increase in incidence of abortions or mortality of offspring was observed in any of the treatment groups in the 3 species. In the guineapigs having ascorbic acid 400 mg/kg from day 23 to 50 of pregnancy there was a significant reduction in the number of stillbirths and an increase in the mean weight of live pups. There was no adverse effect from large daily doses of vitamin C during pregnancy in any of the species examined.
KW - ascorbic acid
KW - pregnancy
KW - Toxicology
KW - guineapigs
KW - hamsters
KW - RATS
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Cricetinae
KW - Muridae
KW - gestation
KW - guinea pigs
KW - guineapig, hamster, rat
KW - vitamin C
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761445339&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy of divided doses of fospirate against immature Echinococcus granulosus infections in dogs.
AU - Schantz, P. M.
AU - Prezioso, U.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 1976///
VL - 37
IS - 5
SP - 619
EP - 620
SN - 0002-9645
AD - Schantz, P. M.: Parasitic Diseases and Vet. Public Health Div., Cent. for Disease Control, US Public Health Service, Atlanta, Ga 30333, USA.
N1 - Accession Number: 19760827431. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science; Veterinary Science
N2 - Dogs experimentally infected with Echinococcus granulosus protoscoleces were given one or 2 doses, on consecutive days starting on the 28th day after infection, of fospirate at 10 to 80 mg/kg body-weight. Autopsy worm counts 48 to 52 days after infection indicated a 70.6 to 94.5% clearance of the worms. It is believed that at least 3 treatments may be necessary for 100% elimination. Vomiting at doses of 40 mg/kg and above interfered with the efficacy of treatment in some dogs.
KW - anthelmintics
KW - control
KW - helminths
KW - parasites
KW - Carnivores
KW - DOGS
KW - Echinococcus
KW - Echinococcus granulosus
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - Echinococcus
KW - Cyclophyllidea
KW - fospirate
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental anisakiasis: cultivation and temperature tolerance determination.
AU - Bier, J. W.
JO - Journal of Milk and Food Technology
JF - Journal of Milk and Food Technology
Y1 - 1976///
VL - 39
IS - 2
SP - 132
EP - 137
AD - Bier, J. W.: Div. of Microbiol., Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19760827678. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - All stages of the anisakine life-cycle, egg, larva and adult, have been used to initiate cultures. Eggs develop to hatching larvae at different temperatures depending on the species or strain. Newly hatched larvae of Phocanema decipiens and Contracaecum osculatum grow to an average 31.1 mm in 52 weeks and 6.5 mm in 32 weeks, respectively. Larvae from fish or those previously cultivated will moult at 35 deg C in a complex culture medium. P. decipiens and Anisakis marina have produced eggs in vitro. A. marina eggs from cultured females produced viable larvae. Freshness of the larvae used to initiate cultures is considered a major factor in success. The histochemistry of the composition and structure of P. decipiens cuticle in larvae from fish and cultures have been defined; experiments have demonstrated that the processes of cuticular deposition and ecdysis are independent. It has been postulated and evidence provided that a neurosecretory mechanism controls ecdysis; it has also been shown that this system can be stimulated by an insect hormone and a synthetic analogue. Larvae in vitro, in fish flesh, and in fried fish fingers, do not survive heating to 60 deg C for one min. The recommended time and temperature found in Japanese and European literature for freezing fish to kill anisakine larvae is -20 deg C for 24 hours; however, some North American species survive after 52 hours at this temperature. [AS]
KW - biological development
KW - development
KW - fish diseases
KW - Food hygiene
KW - helminths
KW - parasites
KW - physiology
KW - temperature
KW - Anisakidae
KW - Anisakis marina
KW - Contracaecum osculatum
KW - fishes
KW - Pseudoterranova decipiens
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Contracaecum
KW - Anisakidae
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Pseudoterranova
KW - Anisakis
KW - Ascaridida
KW - nematodes
KW - parasitic worms
KW - Phocanema decipiens
KW - Secernentea
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760827678&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health aspects of cream-filled pastries. A review.
AU - Bryan, F. L.
JO - Journal of Milk and Food Technology
JF - Journal of Milk and Food Technology
Y1 - 1976///
VL - 39
IS - 4
SP - 289
EP - 296
AD - Bryan, F. L.: US Dep. of Health, Education & Welfare, Public Health Service, Cent. for Disease Control, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19760427942. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Public health aspects of pastries filled with synthetic cream (constituents of the cream include eggs, milk, shortening, sugar, corn starch, flour, salt and vanilla) are reviewed under the following headings: epidemiology, factors contributing to outbreaks, examples of outbreaks, and control.
KW - confectionery
KW - cream
KW - food poisoning
KW - reviews
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760427942&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasmodium knowlesi: morphology and course of infection in rhesus monkeys treated with clindamycin and its N-demythyl-4'-pentyl analog.
AU - Powers, K. G.
AU - Aikawa, M.
AU - Nugent, K. M.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1976///
VL - 40
IS - 1
SP - 13
EP - 24
SN - 0014-4894
AD - Powers, K. G.: Bureau of Vet. Med., Food and Drug Administration, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19762500556. Publication Type: Journal Article. Language: English. Registry Number: 18323-44-9. Subject Subsets: Protozoology; Veterinary Science
N2 - Macaca mulatta infected with Plasmodium knowlesi were treated with clindamycin or N-demethyl-4'-pentyl clindamycin. Fulminating infections were controlled more slowly by these drugs than by chloroquine. Morphological changes proceeding to disintegration were produced in the ribosomes, and the cisternae of the endoplasmic reticulum were dilated. Lesser changes took place in the mitochondria and nucleus. Apparently the main action of clindamycin and its analogue is exerted on the ribosomes.
KW - antiprotozoal agents
KW - clindamycin
KW - DRUG THERAPY
KW - drugs
KW - mode of action
KW - parasites
KW - Macaca mulatta
KW - Plasmodium
KW - Plasmodium knowlesi
KW - Primates
KW - protozoa
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Plasmodium
KW - chemotherapy
KW - Haemosporida
KW - medicines
KW - pharmaceuticals
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762500556&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequential determination of arsenic, selenium, antimony, and tellurium in foods via rapid hybride evolution and atomic absorption spectrometry.
AU - Fiorino, J. A.
AU - Jones, J. W.
AU - Capar, S. G.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1976///
VL - 48
IS - 1
SP - 120
EP - 125
AD - Fiorino, J. A.: Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19761441755. Publication Type: Journal Article. Language: English. Registry Number: 7440-36-0, 7440-38-2, 7782-49-2, 13494-80-9. Subject Subsets: Human Nutrition
N2 - As, Se, Sb and Te are estimated semiautomatically in acid digests of food. Detection limits with 1 g of digested sample are about 10 to 20 ng/g.
KW - antimony
KW - arsenic
KW - estimation
KW - foods
KW - selenium
KW - tellurium
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761441755&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selection of iron sources for cereal enrichment.
AU - Harrison, B. N.
AU - Pla, G. W.
AU - Clark, G. A.
AU - Fritz, J. C.
JO - Cereal Chemistry
JF - Cereal Chemistry
Y1 - 1976///
VL - 53
IS - 1
SP - 78
EP - 84
SN - 0009-0352
AD - Harrison, B. N.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19761442159. Publication Type: Journal Article. Language: English. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Most cereal enrichment is with ferrous sulphate, reduced iron, ferric orthophosphate, or sodium iron pyrophosphate. Selection must be based on bioavailability, technological feasibility and cost. Great variation was found among samples of reduced iron and ferric orthophosphate. A sample of electrolytic iron was separated into fractions 7 to 10 and 27 to 40 mu m. Relative biological value (RBV) of the finer was 68 to 75; that of the coarser was 27 to 29 compared with 100 for ferrous sulphate. Five samples of ferric orthophosphate had RBV of 6 to 46. RBV was positively correlated with solubility in HCl 0.1 mol/litre and negatively with particle size. Eighteen samples of unbleached white flour were enriched with different sources and amounts of Fe and stored in sealed containers. An untrained panel detected rancidity by smell after 4 days at 50 deg C in samples enriched with ferrous sulphate and after 11 to 28 days in samples with reduced iron. All samples stored at 23 deg plus or minus 3 deg were acceptable after 24 months' storage.
KW - cereals
KW - flours
KW - iron
KW - supplements
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional status of children in Nepal, 1975.
AU - Brink, E. W.
AU - Khan, I. H.
AU - Splitter, J. L.
AU - Staehling, N. W.
AU - Lane, J. M.
AU - Nichaman, M. Z.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1976///
VL - 54
IS - 3
SP - 311
EP - 318
SN - 0042-9686
AD - Brink, E. W.: Bureau of Smallpox Eradication, Center for Disease Control, Public Health Service, Dep. Health, Education, and Welfare, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19771454205. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - Survey teams visited 219 villages in rural Nepal and collected data on height, weight and age from 6501 preschool children. With 80% of the reference median weight-for-height as the cut-off point, the prevalence of acute undernutrition was 6.7%. With 90% of the reference median height-for-age as the cut-off point, the prevalence of chronic undernutrition was 52%. The prevalence of chronic undernutrition was significantly higher in the hilly areas. Mean Hb values in blood from 20% of the survey population increased with age with no differnce between hill and terai areas. A Nepal urban elite population was measured for comparison. The survey method used indicators that are economical in terms of money, time and personnel and that provide objective data on the extent and distribution of protein-energy undernutrition and of low Hb values in preschool children.
KW - children
KW - nutritional state
KW - Nepal
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Least Developed Countries
KW - Developing Countries
KW - South Asia
KW - Asia
KW - nutritional status
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771454205&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Failure to demonstrate an association between enamel fluoride concentration and dental caries in the deciduous dentition.
AU - Englander, H. R.
AU - Mellberg, J. R.
JO - Journal of Dental Research
JF - Journal of Dental Research
Y1 - 1976///
VL - 55
IS - 4
SP - 707
EP - 707
SN - 0022-0345
AD - Englander, H. R.: US Dep. Health, Education, and Welfare, Public Health Service, National Inst. Dental Research, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19761449507. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Clinical examinations were made for DMF teeth and tooth surfaces on 138 white children aged 5 to 6 years who were lifelong residents of a community in Illinois where the water is fluoridated. None had erupted permanent teeth and the average DMF score was 1.7 per child. During the following year, each child gave an exfoliated deciduous incisor for study of F- concentrations of the enamel at various depths. The mean F- concentrations at a depth of 5 mu m were the same for the 73 children who were caries-free (874.8 plus or minus 37.0 mu g/g and the 65 who had a DMF surface score of 1 to 14 (872.6 plus or minus 49.3 mu g/g). There was no difference when they were grouped according to range of F- concentrations, e.g., the mean DMF score for the 66 children who had <800 mu g/g in the outer 5 mu m of enamel was similar to that for the 72 with >800 mu g/g (1.6 and 1.9). There was also no inverse relationship between caries and F- concentration at depths of 15, 30 and 60 mu m; and there was a similar lack of relationship between caries experience for buccolingual, occlusal and proximal surfaces and the anterior teeth.
KW - children
KW - dental caries
KW - incidence
KW - teeth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - caries
KW - fluoride content
KW - teeth caries
KW - tooth decay
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Collaborative study of an extension of the Mills et al. method for the determination of pesticide residues in foods.
AU - Finsterwalder, C. E.
JO - Journal of Association of Official Analytical Chemists
JF - Journal of Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 1
SP - 169
EP - 171
AD - Finsterwalder, C. E.: Food and Drug Administration, 1141 Central Pkwy, Cincinnati, OH 45202, USA.
N1 - Accession Number: 19761443539. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The method of Mills et al. (Journal of the Association of Official Analytical Chemists (1963), 46, 186) was used to estimate 7 pesticides in eggs and kale.
KW - eggs
KW - estimation
KW - kale
KW - pesticide residues
KW - Brassica oleracea var. viridis
KW - Brassica oleracea
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Capparales
KW - collards
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761443539&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relationship between the biological availability and solubility rate of reduced iron.
AU - Pla, G. W.
AU - Fritz, J. C.
AU - Rollinson, C. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 3
SP - 582
EP - 583
AD - Pla, G. W.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19761446959. Publication Type: Journal Article. Language: English. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The solubility of 25-mg samples of reduced Fe in 25 ml 0.1 N HCl was directly related to biological availability of Fe estimated by the method of Pla and Fritz (NAR 41, 3150). Availability decreased with an increase in particle size.
KW - iron
KW - biological availability
KW - relation to solubility
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761446959&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of arsenic and selenium in foods by electroanalytical techniques.
AU - Holak, W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 3
SP - 650
EP - 654
AD - Holak, W.: Food and Drug Administration, 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19761446963. Publication Type: Journal Article. Language: English. Registry Number: 7440-38-2, 7782-49-2. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The sample, 1 g, is digested with 10 ml HNO3 and 4 g Mg(NO3)2.6H2O, dissolved in 10 ml 6N HCl and diluted to 25 ml. Se is estimated by cathodic stripping voltammetry and As polarographically.
KW - arsenic
KW - estimation
KW - selenium
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761446963&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methods of analysis approved by the Codex Alimentarius Commission. 1. Acid value.
AU - Horwitz, W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 3
SP - 658
EP - 661
AD - Horwitz, W.: Bureau of Foods, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19761446965. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Animal Nutrition
KW - estimation
KW - acid value
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761446965&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ion selective method for the determination of nitrite in smoked fish.
AU - Sherken, S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 5
SP - 971
EP - 974
AD - Sherken, S.: Food and Drug Administration, 850 Third Ave., Brooklyn, N.Y. 11232, USA.
N1 - Accession Number: 19761451537. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - Extracted nitrite is converted with a measured addition of Na2SO4 buffer to HNO2 which is measured by nitrogen oxide electrode.
KW - estimation
KW - smoked fish
KW - nitrites in tissues
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761451537&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Collaborative study of the determination of sodium in dietetic foods by the sodium ion electrode method.
AU - McNerney, F. G.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 5
SP - 1131
EP - 1134
AD - McNerney, F. G.: Food and Drug Administration, 599 Delaware Ave., Buffalo, NY 14202, USA.
N1 - Accession Number: 19761451550. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 7440-23-5. Subject Subsets: Human Nutrition
N2 - The blonded sample is diluted with buffer and electrode potential is measured before and after addition of increments of Na. Na content is obtained by extrapolation. There was good agreement between collaborators and the method was adopted as official first action.
KW - estimation
KW - sodium
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761451550&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A simplified method for the gas-liquid chromatographic determination of methyl mercury in fish and shellfish.
AU - Watts, J. O.
AU - Boyer, K. W.
AU - Cortez, A.
AU - Elkins, E. R., Jr.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 6
SP - 1226
EP - 1233
AD - Watts, J. O.: Division of Chemistry and Physics, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19771452996. Publication Type: Journal Article. Language: English. Registry Number: 7439-97-6. Subject Subsets: Human Nutrition
N2 - A fish homogenate is extracted under vacuum with acetone. Methyl Hg in the residue is freed with HCl, extracted into benzene and estimated by chromatography. Amounts as small as 0.1 mu g/g can be estimated.
KW - estimation
KW - fish
KW - mercury
KW - shellfish
KW - tissues
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771452996&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Loss of chloride in the official method for the determination of sodium chloride in cereal foods.
AU - Brammell, W. S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1976///
VL - 59
IS - 6
SP - 1396
EP - 1400
AD - Brammell, W. S.: Division of Color Technology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19771453002. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - The official AOAC method 14.129 gave low values for NaCl. It was replaced by the potentiometric method, 32.A01-32.A06, which was adopted as official first action.
KW - cereals
KW - estimation
KW - sodium chloride content
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771453002&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current regulatory status of foods for special dietary uses.
AU - Chopra, J. G.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976///
VL - 66
IS - 4
SP - 351
EP - 353
SN - 0090-0036
AD - Chopra, J. G.: Bureau of Foods, Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19731444231. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Dairy Science
N2 - The Food and Drug Administration (FDA) of the USA has redefined foods for special dietary use. These must meet a special dietary need arising from a physical or physiological condition (e.g., convalescence or pregnancy), or a specific disease or disorder; supply a nutrient to supplement diet by increasing total dietary intake; or meet a special nutritional need as the sole item of the diet. This stricter definition means that the conventional foods with added nutrients or foods for which nutritional claims are made or nutritional information is provided will not be considered as foods for special dietary uses, although they must conform to standard labelling requirements. The new regulation enables industry, the consumer and the FDA to know clearly which special dietary foods belong to that category. The former minimum daily requirements are replaced by sets of recommended daily allowances for 4 groups, infants under 1 year, children of 1 to 4 years, children over 4 years, adults and pregnant and lactating women; the recommended intakes of 12 vitamins and 7 minerals are given. The labels of special dietary foods must show the percentages of the Recommended Dietary Allowances (US) for protein, vitamins and minerals and indicate the usefulness of the food and the dietary property on which it is based. The regulation is designed to protect consumers from toxic quantities of nutrients and safeguard them from unfair deceptive promotional claims. A group of medical foods is recognized, for use only under medical supervision to meet nutritional requirements related to specific medical conditions. Safe limits are set for the use of folic acid, KI and kelp in foods for special dietary uses and in dietary supplements.
KW - diet
KW - food
KW - food legislation
KW - USA
KW - MAN
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dietary use
KW - special diet foods
KW - special foods
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19731444231&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A comparison of the interference of fatty acids in the competitive binding radioassay and radioimmunoassay for serum T4.
AU - Shaw, W.
AU - Powell, J.
AU - Hubert, I. L.
AU - Spierto, F. W.
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 1976///
VL - 73
IS - 1
SP - 25
EP - 29
SN - 0009-8981
AD - Shaw, W.: Immunochemistry Section, Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19761451650. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 51-48-9. Subject Subsets: Human Nutrition
N2 - A number of fatty acids, saturated and unsaturated, interfered with the competitive protein-binding radioassay for serum thyroxine; interference in the radioimmunoassay was negligible.
KW - blood
KW - estimation
KW - thyroxine
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761451650&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemic giardiasis at a resort lodge.
AU - Wright, R. A.
AU - Vernon, T. M.
JO - Rocky Mountain Medical Journal
JF - Rocky Mountain Medical Journal
Y1 - 1976///
VL - 73
IS - 4
SP - 208
EP - 211
AD - Wright, R. A.: Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education and Welfare, Colorado State Dep. of Health, Denver, USA.
N1 - Accession Number: 19772504216. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - During the summer of 1973, 16 of 40 employees at a resort lodge in Colorado, USA, suffered from giardiasis (13 had symptoms and 3 had positive faeces but no symptoms). The average maximal incubation period was 3.2 weeks and the average duration of illness 4.1 weeks. The infection seemed to be derived from the untreated water supply. 81% of the infected group came from outside Colorado, compared with only 39% of the non-infected group, suggesting that Colorado residents had some immunity.
KW - outbreaks
KW - parasites
KW - Mountain States of USA
KW - USA
KW - Giardia duodenalis
KW - man
KW - protozoa
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Giardia lamblia
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19772504216&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Management of type IV hyperlipoproteinemia. Evaluation of practical clinical approaches.
AU - Smith, L. K.
AU - Luepker, R. V.
AU - Rothchild, S. S.
AU - Gillis, A.
AU - Kochman, L.
AU - Warbasse, J. R.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1976///
VL - 84
IS - 1
SP - 22
EP - 28
SN - 0003-4819
AD - Smith, L. K.: Cardiovascular Service and Lab., US Public Health Service Hospital, Room 620, 3100 Wyman Park Drive, Baltimore, MD 21211, USA.
N1 - Accession Number: 19761442035. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A study of lipid concentration in serum from 4000 workers showed 150 of them to have type IV hyperlipoproteinaemia. Those 150 subjects 20 to 49 years old were then randomly divided into treatment subgroups: treatment by clinic nutritionist and physician with the (American) National Heart and Lung Inst. type IV diet for 6 weeks, then with clofibrate for 18 weeks (Group A); same treatment by private physician (group B); no intervention for 24 weeks but the subjects were advised of abnormality (group C). The group A mean fasting serum triglyceride of 407 mg/100 ml declined 50% at 6 weeks and 61% at 12 weeks but had not declined further at 24 weeks. Group B triglyceride decreased 42, 50 and 41%, correspondingly. Group C triglyceride declined 20% by the 24th week. Bodyweight decreased by 8% (A) and 4% (B) at 6 weeks and was unchanged at 24 weeks. The maximum cholesterol decrease (A) was 11%. Type IV hyperlipoproteinaemia could readily be identified in a working population and treatment by clinic or private physician would considerably lower serum triglyceride values.
KW - hyperlipoproteinaemia treatment
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761442035&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Experimental anisakiasis in pigs: gross and microscopic pathology with larval Anisakis sp. and Phocanema sp. nematodes from fishes.
AU - Bier, J. W.
AU - Jackson, G. J.
AU - Earl, F. L.
AU - Knollenberg, W. G.
T2 - Transactions of the American Microscopical Society
JO - Transactions of the American Microscopical Society
JF - Transactions of the American Microscopical Society
Y1 - 1976///
VL - 95
IS - 2
SP - 264
EP - 265
SN - 0003-0023
AD - Bier, J. W.: Div. of Microbiol., Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19760828572. Language: English. Subject Subsets: Helminthology; Veterinary Science
KW - fish diseases
KW - helminths
KW - Host range
KW - parasites
KW - pathology
KW - Anisakidae
KW - Anisakis
KW - fishes
KW - PIGS
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anisakidae
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - Ascaridida
KW - hogs
KW - nematodes
KW - parasitic worms
KW - Phocanema
KW - Secernentea
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760828572&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Experimental anisakiasis in pigs: hematology and clinical chemistry with larval Anisakis sp. and Phocanema sp. nematodes from fishes.
AU - Bier, J. W.
AU - Jackson, G. J.
AU - Gerding, T. A.
T2 - Transactions of the American Microscopical Society
JO - Transactions of the American Microscopical Society
JF - Transactions of the American Microscopical Society
Y1 - 1976///
VL - 95
IS - 2
SP - 265
EP - 265
SN - 0003-0023
AD - Bier, J. W.: Di. of Microbiol., Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19760828573. Language: English. Subject Subsets: Helminthology; Veterinary Science
KW - fish diseases
KW - haematology
KW - helminths
KW - Host range
KW - parasites
KW - Anisakidae
KW - Anisakis
KW - fishes
KW - PIGS
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anisakidae
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - Ascaridida
KW - haematology & clinical chemistry
KW - hematology
KW - hogs
KW - nematodes
KW - parasitic worms
KW - Phocanema
KW - Secernentea
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19760828573&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Subcutaneous nodules as a manifestation of onchocerciasis.
AU - Palomar, J. M.
AU - Bray, D. M., III
AU - Grannis, F. W.
AU - Beaver, P. C.
JO - Archives of Surgery
JF - Archives of Surgery
Y1 - 1976///
VL - 111
IS - 8
SP - 909
EP - 911
AD - Palomar, J. M.: Dep. of Surgery, Public Health Service Hospital, New Orleans, USA.
N1 - Accession Number: 19770831798. Publication Type: Journal Article. Language: English. Subject Subsets: Leisure, Recreation, Tourism; Helminthology
N2 - A case of Onchocerca volvulus infection acquired in northern Brazil which manifested as subcutaneous nodules in the groin and flank 2 years after return to the USA is described. Microfilariae were not demonstrated in sections of skin or in skin snips but adult worms were teased out of an excised nodule.
KW - helminths
KW - parasites
KW - travel
KW - Brazil
KW - man
KW - Onchocerca volvulus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - subcutaneous nodules
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770831798&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Complete amino acid analysis of proteins from a single hydrolysate.
AU - Simpson, R. J.
AU - Neuberger, M. R.
AU - Liu, T. Y.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1976///
VL - 251
IS - 7
SP - 1936
EP - 1940
SN - 0021-9258
AD - Simpson, R. J.: Bureau of Biologics, Food and Drug Administration, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19761445285. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The sample is hydrolysed in vacuo at 115 deg for 22 to 72 h with 4 N methanesulphonic acid containing 0.2% 3-(2-aminoethyl) indole. Half-cystine is estimated as S-sulphocysteine by treating the hydrolysate with dithiothreitol then excess tetrathionate. Values for all amino acids were close to expected theoretical values for proteins examined. Neutralized hydrolysate can be applied directly to an ion-exchange column. The method distinguishes between free sulphydryl groups as S-carboxymethylcysteine and disulphides as S-sulphocysteine. Tryptophan remains sensitive to carbohydrate in the sample.
KW - amino acids
KW - estimation
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19761445285&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fish and shellfish poisoning.
AU - Hughes, J. M.
AU - Merson, M. H.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1976///
VL - 295
IS - 20
SP - 1117
EP - 1120
SN - 0028-4793
AD - Hughes, J. M.: Enteric Diseases Branch, Bacterial Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service US Dep. Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19771452888. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - The causes of fish and shellfish poisoning are reviewed. Toxins in vertebrate fish are in 3 categories: ichthyosarcotic fish contain toxin in muscle, viscera, skin or mucus and are responsible for most cases of fish poisoning; ichthyootoxic fish have toxin in their gonads and ichthyohaemotoxic fish contain toxin in the blood, but poisoning by either of these is relatively rare; of the 9 types of ichthyosarcotoxism, ciguatera, scombroid and puffer-fish poisoning (tetrodotoxism) are the most common. Shellfish may cause paralysis if they contain toxin derived from the dinoflagellates Gonyaulax catanella or G. tamarensis or may cause a milder neurotoxic illness if they are contaminated with toxin derived from the dinoflagellate Gymnodinium breve. Diagnosis and treatment are discussed.
KW - poisoning
KW - shellfish
KW - fish poisoning
KW - toxicosis
KW - toxin sources
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771452888&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Atypical radiographic features in Pneumocystis carinii pneumonia.
AU - Doppman, J. L.
JO - National Cancer Institute Monograph
JF - National Cancer Institute Monograph
Y1 - 1976///
IS - 43
SP - 89
EP - 95
AD - Doppman, J. L.: National Institutes of Health, Public Health Service, Dep. of Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19780848061. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - In 30 patients with confirmed Pneumocystis pneumonia the typical radiographic picture was one of acute bilateral perihilar and basilar infiltrate progressing to diffuse alveolar consolidation within 3 to 5 days, unassociated with adenopathy or pleural changes. In some patients however various atypical findings were present on some occasions.
KW - diagnosis
KW - parasites
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - invertebrates
KW - diagnosis by X-rays
KW - fungus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780848061&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New in vitro approach to quantitation of Trypanosoma cruzi vertebrate cell interactions.
AU - Dvorak, J. A.
JO - Scientific Publication, Pan American Health Organization
JF - Scientific Publication, Pan American Health Organization
Y1 - 1976///
IS - 318
SP - 109
EP - 120
AD - Dvorak, J. A.: Lab. of Parasit. Diseases, National Inst. of Allergy and Infectious Diseases, U.S. Public Health Service, Bethesda, Md., USA.
N1 - Accession Number: 19770837455. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Quantitative studies of Trypanosoma cruzi-vertebrate cell interactions using a perfusible culture chamber are described and discussed. The interaction was subdivided into the penetration of cells by trypomastigotes, the reorganization of trypomastigotes to amastigotes, the reproduction of amastigotes, the differentiation of amastigotes to trypomastigotes and the escape of trypomastigotes from the dead host cell.
KW - parasites
KW - protozoa
KW - Trypanosoma cruzi
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - behaviour in vertebrate cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770837455&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Modification of the Ritchie formol-ether concentration technique with special reference to its use in detecting eggs of Schistosoma mansoni.
AU - Knight, W. B.
AU - Hiatt, R. A.
AU - Cline, B. L.
AU - Ritchie, L. S.
T2 - Resumenes de trabajos libres. Congreso (IV) Latinoamericano de Parasitologia, etc., San Jose, Costa Rica, 7-11 Dec., 1976.
JO - Resumenes de trabajos libres. Congreso (IV) Latinoamericano de Parasitologia, etc., San Jose, Costa Rica, 7-11 Dec., 1976.
JF - Resumenes de trabajos libres. Congreso (IV) Latinoamericano de Parasitologia, etc., San Jose, Costa Rica, 7-11 Dec., 1976.
Y1 - 1976///
SP - 87
EP - 87
CY - ; Federacion Latinoamericana de Parasitologos; Costa Rica
PB - Asociacion Costarricense de Microbiologia y Parasitologia.
AD - Knight, W. B.: San Juan Lab., Center for Disease Control, U.S. Public Health Service; and Puerto Rico Nuclear Center, San Juan, Puerto Rico.
N1 - Accession Number: 19770833940. Publication Type: Conference paper. Language: English. Subject Subsets: Helminthology
KW - detection
KW - helminths
KW - ova
KW - parasites
KW - techniques
KW - Schistosoma mansoni
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - parasitic worms
KW - Strigeida
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Amebic diseases: resurgence of the old, emergence of the new.
AU - Healy, G. R.
T2 - 36th Annual Meeting, Institute of Food Technologist, June 6-9, 1976, Anaheim, California, USA. Program. Abs. No. 288.
JO - 36th Annual Meeting, Institute of Food Technologist, June 6-9, 1976, Anaheim, California, USA. Program. Abs. No. 288.
JF - 36th Annual Meeting, Institute of Food Technologist, June 6-9, 1976, Anaheim, California, USA. Program. Abs. No. 288.
Y1 - 1976///
SP - 173
EP - 173
AD - Healy, G. R.: Center for Disease Control, Health Services & Mental Health Adm., Public Health Service, USDHEW, Atlanta, GA 30333, USA.
N1 - Accession Number: 19762501736. Publication Type: Conference paper. Language: English. Subject Subsets: Protozoology
KW - amoebae
KW - parasites
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - general account
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19762501736&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Unilateral breast-feeding and breast cancer.
AU - Ing, R.
AU - Ho, J. H. C.
AU - Petrakis, N. L.
JO - Lancet
JF - Lancet
Y1 - 1977///
VL - 2
IS - 8029
SP - 124
EP - 127
AD - Ing, R.: US Public Health Service Hospital, Baltimore, Maryland, USA.
N1 - Accession Number: 19770436770. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Dairy Science
N2 - Women of fishing villages in Hong Kong by custom breast fed with only the right breast. Records of the radiotherapy divisions in Hong Kong between 1958 and 1975 were searched, and breast cancer patients were interviewed for a detailed history of lactation. The overall left/right ratio of cancer in the breasts of 2372 women with unilateral breast carcinoma was 0.97, indicating that breast cancer was equally distributed between the 2 sides. Of 73 patients with a history of exclusively one-sided breast feeding, 27 of 34 patients aged more than or equal to 55 (79.4%) and 19 of 39 patients of <55 (48.7%) had a carcinoma in the unsuckled breast. Comparisons of patients who had nursed unilaterally with nulliparous patients and with patients who had borne children but had not breast fed indicated a highly significantly increased risk of cancer in the unsuckled breast. No statistically significant differences in laterality of breast cancer were found in 52 patients who had for convenience nursed to a greater extent from one side than the other.
KW - breast feeding
KW - incidence
KW - infants
KW - MAMMARY GLAND NEOPLASMS
KW - Hong Kong
KW - MAN
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Central Southern China
KW - China
KW - Developing Countries
KW - East Asia
KW - Asia
KW - mammary tumour
KW - Xianggang
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770436770&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Unilateral suckling and breast cancer. / [Reply].
AU - Ing, R.
AU - Ho, J. H. C.
AU - Petrakis, N. L.
JO - Lancet
JF - Lancet
Y1 - 1977///
VL - 2
IS - 8039
SP - 656
EP - 657
AD - Ing, R.: US Public Health Service Hospital, Baltimore, Maryland 21211, USA.
N1 - Accession Number: 19770437394. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Dairy Science
N2 - This letter is in reply to MacMahon et al. [see preceding abstr.]. The authors firstly point out an editorial error by the Lancet in the publication of their paper [DSA 39, 7313]. Background information is then given on the Tanka custom of unilateral suckling, which is absolute but is however now tending to be abandoned. Mothers who do use both breasts have been found to have a good milk supply on both sides. The reason for grouping the mothers according to age, either <55 or more than or equal to 55 yr, was based on menopausal status; a table gives the age distribution of the cancer cases. They also discuss why absolute non-suckling could have a different effect on the breast than partial use, and why the predominance of breast cancer on the left side is due to the environmental factor (unilateral suckling) rather than the genes.
KW - breast feeding
KW - incidence
KW - infants
KW - MAMMARY GLAND NEOPLASMS
KW - Hong Kong
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Central Southern China
KW - China
KW - Developing Countries
KW - East Asia
KW - Asia
KW - mammary tumour
KW - Xianggang
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770437394&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition education in child feeding programs in the developing countries.
AU - Veen, M. S. van
AU - Close, A. K.
JO - A.I.D. Research and Development Abstracts
JF - A.I.D. Research and Development Abstracts
Y1 - 1977///
VL - 5
IS - 1
EP - p.2
AD - Veen, M. S. van: US Public Health Service, Department of Health, Education and Welfare, Washington, D.C. 20201, USA.
N1 - Accession Number: 19771837329. Publication Type: Journal Article. Language: English.
N2 - This booklet is intended for village workers and others involved in child feeding in the developing countries. By making nutrition education an important part of their feeding programme activities, village workers can greatly increase their contribution to the attack on malnutrition among children. This booklet can assist workers to teach mothers and children about the foods children need for growth and health, and how to use local foods to improve their diets. In the long run, this nutrition education may have a more lasting effect and may do as much for the prevention of future malnutrition as the contribution of actual foods. Chapters in the book discuss the double purpose of child feeding programmes; basic facts about food; setting goals to fit the community; some general rules for teaching; working with mothers of pre-school children; teaching children in school feeding programmes. Appendices present an illustrative Pre-school Child's Height and Weight Chart; a Questionnaire for Learning Children's Food Habits; and a list of reference publications.
KW - child care
KW - children
KW - education
KW - nutrition
KW - Developing countries
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - countries
KW - Third World
KW - Underdeveloped Countries
KW - Public Services and Infrastructure (UU300)
KW - Extension and Advisory Work (CC200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771837329&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The laboratory diagnosis of Pneumocystis carinii pneumonia.
AU - Kagan, I. G.
AU - Norman, L.
JO - Health Laboratory Science
JF - Health Laboratory Science
Y1 - 1977///
VL - 14
IS - 3
SP - 155
EP - 163
AD - Kagan, I. G.: Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19770839591. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - In the diagnosis of Pneumocystis carinii infection in man, exacting methods of staining must be used for the organism to be visualized in lung tissue. Smears should be stained with Chalvardjian and Grawe's toluidine blue and others with Giemsa. Tissue sections should be stained with Grocott's silver stain. Gram-Weigert stain can also be used. Techniques for sample collection, which range from open lung biopsy to endobronchial brush methods or collection of sputum, are discussed. Recent advances in the serological diagnosis and in the culture of the organism are also covered. [AS]
KW - diagnosis
KW - laboratory diagnosis
KW - parasites
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - invertebrates
KW - fungus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770839591&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of the cliff swallow bug (Oeciacus vicarius) in the natural cycle of a western equine encephalitis-related alphavirus.
AU - Hayes, R. O.
AU - Francy, D. B.
AU - Lazuick, J. S.
AU - Smith, G. C.
AU - Gibbs, E. P. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1977///
VL - 14
IS - 3
SP - 257
EP - 262
SN - 0022-2585
AD - Hayes, R. O.: Vector-borne Diseases Division, Bureau of Laboratories, Public Health Service, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19780552089. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science
N2 - The first isolations are reported of an alphavirus related serologically to western equine encephalitis (WEE) virus from naturally infected examples of Oeciacus vicarius Horv. in north-eastern Colorado in September 1973. The cimicids were collected from inactive nests of the house sparrow (Passer domesticus) within abandoned nests of (migratory) cliff swallows (Petrochelidon pyrrhonota), and similar strains of the virus were obtained from nestlings of both these bird species in May-July 1974. Twelve species of mosquitoes were collected at the study site in 1974, and of 6 strains of virus isolated from Culex tarsalis Coq., one (in August) was a strain of WEE. It is suggested from monthly observations on viruses and their bird and insect hosts in 1974-75 that O. vicarius can support the endemic persistence of the WEE-related alphavirus in Colorado, and that this overwintering capability, together with the relation between infected bugs and susceptible nestling birds in the spring, could provide an overwintering mechanism for the virus.
KW - Epidemiology
KW - introduced species
KW - nests
KW - overwintering
KW - vectors
KW - viral diseases
KW - Colorado
KW - USA
KW - Birds
KW - Cimicidae
KW - Culex tarsalis
KW - Culicidae
KW - equine encephalomyelitis virus
KW - Hemiptera
KW - Hirundo
KW - Hirundo pyrrhonota
KW - Oeciacus vicarius
KW - Passer domesticus
KW - Passeriformes
KW - Togaviridae
KW - viruses
KW - western equine encephalitis virus
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Heteroptera
KW - Hemiptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Culex
KW - Culicidae
KW - Diptera
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Hirundo
KW - Hirundinidae
KW - Passeriformes
KW - birds
KW - Passer
KW - Ploceidae
KW - equine encephalomyelitis virus
KW - Oeciacus
KW - Cimicidae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - alphavirus overwintering
KW - alphaviruses
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Petrochelidon
KW - Petrochelidon pyrrhonota
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780552089&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of vitamin A on toxicity of hexachlorophene in the rat.
AU - Hanig, J. P.
AU - Morrison, J. M., Jr.
AU - Darr, A. G.
AU - Krop, S.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1977///
VL - 15
IS - 1
SP - 35
EP - 38
AD - Hanig, J. P.: Division of Drug Biology, Food and Drug Administration, US Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771455901. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 70-30-4, 68-26-8. Subject Subsets: Human Nutrition
N2 - Osborne-Mendel male rats weighing 100 to 200 g were given vitamin A 0.83 or 10 mg/kg by tube daily or 3 times those doses every third day for 2 weeks before and while they were given the neurotoxic substance hexachlorophene (HCP) 50 or 75 mg/kg for 45 to 66 days. The small amounts of vitamin A protected against the toxic effects of small amounts of HCP and large amounts of vitamin A protected against large amounts of HCP, death rate being reduced. Vitamin A 30 mg/kg every third day for 2 weeks did not significantly change the single-dose LD50 of HCP. When weanling rats were given a diet free from vitamin A for 10 weeks and then given HCP from 10 to 75 mg/kg daily, the toxicity of HCP was significantly greater than in controls given a diet containing vitamin A 10 000 IU/kg. Cerebrospinal fluid pressure in rats deprived of vitamin A but not given HCP was 88 mm saline compared with 251 mm in rats given vitamin A and HCP.
KW - hexachlorophene
KW - intake
KW - retinol
KW - toxicity
KW - RATS
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771455901&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term effects of calcium carrageenan in rats. 1. Effects on reproduction.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Prew, J. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1977///
VL - 15
IS - 6
SP - 533
EP - 538
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781466802. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9000-07-1. Subject Subsets: Human Nutrition
N2 - 1. For 3 generations Osborne-Mendel rats were given a diet with 0.5, 1.0, 2.5 or 5.0% calcium carrageenan. Although carrageenan caused dose-related and significant decreases in the weights of offspring at weaning, it had no effect on fertility, mean litter size, mean number of liveborn young, viability or survival of offspring.
KW - carrageenan
KW - food additives
KW - reproduction
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - calcium carrageenan affects reproduction
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term effects of calcium carrageenan in rats. 2. Effects on foetal development.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Prew, J. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1977///
VL - 15
IS - 6
SP - 539
EP - 545
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781466803. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9000-07-1. Subject Subsets: Human Nutrition
N2 - 2. Osborne-Mendel rats were given carrageenan as in part 1 for 3 generations. Developmental effects were studied in the second and third generations. There was no dose-related effect on maternal weight gain. Average numbers of corpora lutea, implantations and early or late deaths, and mean percentage resorptions per litter showed no dose-related difference. No specific external, skeletal or soft-tissue anomaly could be related with dosage.
KW - carrageenan
KW - FETUS
KW - food additives
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - calcium carrageenan affects foetal development
KW - foetus
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781466803&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Federal nutrition support programs for children.
AU - Egan, M. C.
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
Y1 - 1977///
VL - 24
IS - 1
SP - 229
EP - 239
SN - 0031-3955
AD - Egan, M. C.: Dep. Health, Education, and Welfare, Public Health Service, Health Services Administration, Rockville, Md. 20857, USA.
N1 - Accession Number: 19771459581. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition
KW - children
KW - nutrition programmes
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - nutrition programs
KW - United States of America
KW - US nutrition programmes for children
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771459581&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual lipids and proximate analysis of various foods. 1. French fried potatoes from ten chain restaurants.
AU - Hubbard, W. D.
AU - Prosser, A. R.
AU - Sheppard, A. J.
AU - Newkirk, D. R.
AU - Osgood, T.
AU - Tombropoulos, E.
AU - Jones, S. T.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1977///
VL - 25
IS - 6
SP - 1280
EP - 1281
SN - 0021-8561
AD - Hubbard, W. D.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781466778. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 57-88-5. Subject Subsets: Leisure, Recreation, Tourism; Horticultural Science; Human Nutrition
N2 - 1. Fried potatoes were obtained every third day from 10 chain restaurants, 6 samples from each. Values are tabulated for proximate constituents, fatty acids, sterols and cis,cis-methylene interrupted polyunsaturated triglycerides. The data show that the selection of cooking oils used by even a single restaurant varied. Contents were protein 3.4 to 4.6, fat 14.0 to 28.4, ash 1.4 to 3.0, moisture 32.1 to 43.3% and cholesterol 0 to 19.0 mg/100 g.
KW - catering
KW - cholesterol
KW - fat
KW - lipids
KW - potatoes
KW - protein
KW - USA
KW - Solanum tuberosum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - composition of fried potatoes in restaurants
KW - food service
KW - lipins
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Morbidity from Schistosoma mansoni in a Puerto Rican community; a population-based study.
AU - Cline, B. L.
AU - Rymzo, W. T.
AU - Hiatt, R. A.
AU - Knight, W. B.
AU - Berrios-Duran, L. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 1
SP - 109
EP - 117
SN - 0002-9637
AD - Cline, B. L.: San Juan Labs., Bureau of Labs., Center for Disease Control, Public Health Service, US Dep. of Health, Education, and Welfare, GPO Box 4532, San Juan, Puerto Rico 00936.
N1 - Accession Number: 19770833456. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - A population-based approach was used to investigate morbidity from Schistosoma mansoni in a rural community in eastern Puerto Rico, representative of remaining endemic foci on the island. In 1974 the prevalence of infection in 855 of 1,056 inhabitants was 32.7% and the geometric mean egg output was 17.6 e.p.g. A standardized medical history was obtained, and physical and laboratory examinations were performed on 737 (70%) of the community residents. Quantitative S. mansoni egg counts were performed on 1.0 g of faeces with a modified Ritchie formol-ether concentration technique; other intestinal parasites were recorded on a semi-quantitative basis. Interviews and physical examinations were conducted "blind" to minimize observer bias, and statistical analysis was made on data from 149 infected subjects and 149 non-infected controls matched by age and sex. For subjects under 20 years of age the frequency of hookworm infection and trichuriasis and absolute eosinophilia was significantly higher in the infected group, but no difference was found in the frequency of signs and symptoms of schistosomiasis. For subjects aged 20 years and over, the symptom "blood in the stool" was reported frequently in the infected group, but haematocrit level did not differ between infected and non-infected controls. Although palpable livers were noted more frequently in infected (8) than in non-infected (one) subjects aged 20 years and over, further evaluation of these subjects cast doubt upon a causal role for S. mansoni. These data indicate that morbidity from S. mansoni infection in the community is low, a finding consistent with the apparent decline in S. mansoni infection in Puerto Rico during recent decades and the relatively low intensity of infection in this community. Nevertheless, because of the sporadic occurrence of S. mansoni disease on the island, and because heavily infected subjects are at greater risk of disease, treatment is recommended for community residents with high egg output. [AS]
KW - helminths
KW - morbidity
KW - parasites
KW - pathogenicity
KW - Puerto Rico
KW - man
KW - Schistosoma mansoni
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - parasitic worms
KW - Porto Rico
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770833456&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiologic investigation of echinococcosis in American Indians living in Arizona and New Mexico.
AU - Schantz, P. M.
AU - Reyn, C. F. von
AU - Welty, T.
AU - Andersen, F. L.
AU - Schultz, M. G.
AU - Kagan, I. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 1
SP - 121
EP - 126
SN - 0002-9637
AD - Schantz, P. M.: Bureau of Epidemiology, Center for Disease Control, Public Health Service, US. Dep. of Health, Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19770833458. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - Between 1972 and 1975, 10 cases of hydatid diagnosed in American Indians in Arizona and New Mexico were investigated. 6 patients were Navajo, 2 Zuni, and 2 Santo Domingo Indians. An additional case in a Navajo man was detected by serologic testing of patients' families. Dogs owned by 3 of the Navajo patients were infected with Echinococcus granulosus. Arecoline-purge testing of 110 dogs in the Zuni pueblo demonstrated echinococcosis in a single stray dog. Slaughter of Navajo-owned sheep indicated that the infection was enzootic in this host. It is suggested that man is infected from dogs which are infected by eating viscera of home-butchered sheep (of local or off reservation origin).
KW - epidemiology
KW - helminths
KW - hydatids
KW - parasites
KW - Mountain States of USA
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An island-wide epidemic of salmonellosis in Trinidad traced to contaminated powdered milk.
AU - Weissman, J. B.
AU - Deen, R. M. A. D.
AU - Williams, M.
AU - Swanston, N.
AU - Ali, S.
JO - West Indian Medical Journal
JF - West Indian Medical Journal
Y1 - 1977///
VL - 26
IS - 3
SP - 135
EP - 143
SN - 0043-3144
AD - Weissman, J. B.: Cent. for Disease Control, Public Health Service, US Dep. Health Education and Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19780444887. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Between March 1 and Nov. 30 1973, an epidemic of Salmonella derby gastroenteritis occurred in Trinidad. Approx. 3000 people were affected. Cases occurred throughout the island roughly in proportion to the population, but most were in infants and small children. Consumption of dried milk was significantly associated with illness. 7 different brands of imported dried milk, packaged at a single processing plant near Port-of-Spain were significantly associated with salmonellosis. Investigations at the processing plant disclosed several packaging procedures that could have permitted contamination during canning, but the specific mode of contamination could not be demonstrated.
KW - dried milk
KW - incidence
KW - isolation
KW - salmonellosis
KW - Trinidad and Tobago
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Caribbean Community
KW - Commonwealth of Nations
KW - Developing Countries
KW - Lesser Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Threshold Countries
KW - bacterium
KW - milk powder
KW - milk-borne diseases
KW - Salmonella derby
KW - Salmonella infections
KW - Trinidad & Tobago
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Morphologic variants of Anopheles albimanus and susceptibility to Plasmodium vivax and P. falciparum.
AU - Warren, McW.
AU - Collins, W. E.
AU - Richardson, B. B.
AU - Skinner, J. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 4
SP - 607
EP - 611
SN - 0002-9637
AD - Warren, McW.: Vector Biol. & Control Div., Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19770837553. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Three morphologically different, true-breeding phenotypes were isolated from a strain of Anopheles albimanus from Lake Apastepeque, El Salvador. Studies with co-indigenous strains of Plasmodium vivax and P. falciparum showed that these phenotypes differed significantly in their susceptibility to malaria parasites. This difference was apparent both in the number of mosquitoes that became infected and the level of infection obtained. Variations in malaria susceptibility were markedly greater with P. vivax than with P. falciparum. The significance of genetic variants within a local vector population with respect to the epidemiology of malaria is discussed. [AS]
KW - insect pests
KW - parasites
KW - resistance
KW - susceptibility
KW - El Salvador
KW - Anopheles albimanus
KW - Culicidae
KW - insects
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - mosquitoes
KW - pest insects
KW - Salvador
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Endemic amebiasis in an extended family.
AU - Spencer, H. C.
AU - Muchnick, C.
AU - Sexton, D. J.
AU - Dodson, P.
AU - Walls, K. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 4
SP - 628
EP - 635
SN - 0002-9637
AD - Spencer, H. C.: Bureaus of Epidemiology and Labs., Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19770837556. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Two members of an extended Spanish-American family living in 28 households in a rural part of Texas, USA, suffered from amoebic liver abscess simultaneously. Previously 5 family members had had liver abscess and 2 died. 45.7% of 162 members had a positive haemagglutination test for amoebiasis and 12.6% of of 111 members had Entamoeba histolytica cysts or trophozoites in a stool sample. In a sample of the surrounding community, only 0.3% were serologically positive. Transmission of infection inside the family seemed to be by person-to-person. Water supplies were not contaminated.
KW - epidemiology
KW - parasites
KW - USA
KW - West North Central States of USA
KW - Entamoeba histolytica
KW - man
KW - protozoa
KW - Entamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - North Central States of USA
KW - USA
KW - extended family
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The seroepidemiology of malaria in Middle America. IV. Passage of malaria antibodies from mothers to infants.
AU - Collins, W. E.
AU - Cedillos, R. A.
AU - Warren, McW.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 6, Pt.1
SP - 1105
EP - 1107
SN - 0002-9637
AD - Collins, W. E.: Central American Res. Sta, Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education & Welfare, San Salvador, El Salvador.
N1 - Accession Number: 19780845036. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - In an area of El Salvador moderately endemic for malaria, use of the indirect fluorescent antibody test (IFAT) showed that 44% of the infants (born to mothers who had IFAT response to Plasmodium vivax of 1:20 or higher during the latter part of their pregnancy) had positive IFAT responses of 1:10 or higher to this antigen. No serum from an infant was positive in the absence of some level of malarial response to the mother. [AS]
KW - immunity
KW - immunology
KW - parasites
KW - El Salvador
KW - man
KW - Plasmodium vivax
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Salvador
KW - transplacental transfer of antibodies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A precipitin test for the diagnosis of human abdominal angiostrongyliasis.
AU - Sauerbrey, M.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 6, Pt.1
SP - 1156
EP - 1158
SN - 0002-9637
AD - Sauerbrey, M.: Central America Res. Sta., Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, San Salvador, El Salvador, Central America.
N1 - Accession Number: 19780845045. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - A precipitin reaction was observed when sera of cotton rats infected either naturally or experimentally with Angiostrongylus costaricensis were tested by gel double-diffusion against sera obtained from 3 biopsy-confirmed human cases of A. costaricensis. With immunoelectrophoresis the antigen was demonstrated in the serum of infected rats. The antibody in the human serum was mostly of the IgG type. No cross reactions were seen with the common intestinal helminths, or individuals serologically positive for Toxocara, A. cantonensis, Chagas' disease, amoebiasis, leishmaniasis, toxoplasmosis, or syphilis. [AS]
KW - helminths
KW - IMMUNODIAGNOSIS
KW - immunology
KW - parasites
KW - Angiostrongylus costaricensis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Angiostrongylus
KW - Angiostrongylidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - diagnosis by gel double diffusion
KW - nematodes
KW - parasitic worms
KW - Parastrongylus costaricensis
KW - Secernentea
KW - serological diagnosis
KW - Strongylida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the indirect immunofluorescence and complement fixation tests for the serodiagnosis of schistosomiasis.
AU - Wilson, M.
AU - Fried, J.
AU - McQuay, R. M.
AU - Sulzer, A. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1977///
VL - 26
IS - 6, Pt.1
SP - 1159
EP - 1163
SN - 0002-9637
AD - Wilson, M.: Parasit. Div., Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19780845046. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - Sera from patients with a variety of infections were used to compare the sensitivity and specificity of the complement fixation (CF) and the indirect immunofluorescence (IIF) tests for schistosomiasis. Adult Schistosoma mansoni antigens were used in both tests. The sensitivities of the IIF and CF tests were 95% and 69%, respectively; the specificities were 98% and 100%, respectively. There was no statistical difference between the number of positive reactors among those individuals with no detectable helminth infection and those infected with helminths other than schistosomes. Infected people native to endemic areas had lower reactivity in both tests than did infected US citizens who resided in endemic areas for only a few years. We concluded that the IIF test with adult antigen was more sensitive than and as specific as the CF test; therefore, the IIF test is the procedure of choice for routine diagnostic serology of schistosomiasis. [AS]
KW - helminths
KW - IMMUNODIAGNOSIS
KW - immunology
KW - parasites
KW - man
KW - Schistosoma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - diagnosis by IFAT & CFT
KW - parasitic worms
KW - serological diagnosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative aspects of the infection of Simulium ochraceum by Onchocerca volvulus.
AU - Collins, R. C.
AU - Campbell, C. C.
AU - Wilton, D. P.
AU - Newton, L.
JO - Tropenmedizin und Parasitologie
JF - Tropenmedizin und Parasitologie
Y1 - 1977///
VL - 28
IS - 2
SP - 235
EP - 243
AD - Collins, R. C.: Bureau of Tropical Diseases, Center for Disease Control, US Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 19770547084. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology; Helminthology
N2 - Satiated adults of Simulium ochraceum Wlk. were collected from 10 men in Guatemala known to be infected with low to moderate numbers of microfilariae of Onchocerca volvulus. Some flies from each person were dissected 6-10 h after satiation to determine mean microfilarial intake from each person and the number escaping to the haemocoel (thoracic microfilariae). Other flies were maintained in individual plastic tubes on a 10% sucrose solution (with antibiotics) until infective larvae developed. Surviving flies were dissected individually and the number of infective larvae recorded.Overall survival to the infective stage 8 days after satiation was 46.9%. Flies from 3 men had mean microfilarial intakes of 1.7, 2.6 and 12.5/fly and no thoracic microfilariae. In flies from the other 7 men, mean microfilarial intake ranged from 24.2 to 117.8/fly, and these intakes were associated with means of 0.17-1.76 thoracic microfilariae/fly. The correlations between mean microfilarial intakes and mean numbers of thoracic microfilariae and percentages of flies with thoracic microfilariae were highly significant. The correlations between mean microfilarial intake and mean numbers of infective larvae (in surviving flies) and the percentages of surviving flies with infective larvae were also highly significant. There was a ratio of nearly 1:1 between thoracic microfilariae in dissected flies and infective larvae in surviving flies, both quantitatively (mean numbers of larvae) and qualitatively (percentages). Men with low levels of infection with O. volvulus are probably not important reservoirs of infection for S. ochraceum and may not be important in the transmission of onchocerciasis.<new para>ADDITIONAL ABSTRACT:<new para>Simulium ochraceum were collected after feeding on 10 patients with onchocerciasis in Guatemala and dissected at intervals to study the development sf the worms. 46.9% of the flies survived for 8 days, which is the time the worms required to become infective; many of the heavily infected flies died within 24 hours of feeding. Flies from 3 lightly infected patients (uptake up to 12.5 microfilariae per fly) never developed infective larvae. In flies which took up 24 to 118 microfilariae per fly, the number of larvae in the thorax ranged from 0.17 to 1.76 per fly, being correlated with the initial uptake of microfilariae. Practically all larvae in the thoracic muscles developed into infective larvae. Patients with scanty infections of Onchocerca are probably not significant reservoirs of infection for S. ochraceum.
KW - development
KW - epidemiology
KW - helminths
KW - infectivity
KW - parasites
KW - Guatemala
KW - Diptera
KW - Insects
KW - man
KW - Nematoda
KW - Onchocerca volvulus
KW - Simuliidae
KW - Simulium ochraceum
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Diptera
KW - Simulium
KW - Simuliidae
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - blackflies
KW - buffalo gnats
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A comparison of individual dissection and mass separation for recovery of Onchocerca larvae from vector black flies.
AU - Wilton, D. P.
AU - Collins, R. C.
AU - Ash, L. R.\Riley, J. M.\Schacher, J. F.
JO - Tropenmedizin und Parasitologie
JF - Tropenmedizin und Parasitologie
Y1 - 1977///
VL - 28
IS - 3
SP - 384
EP - 386
AD - Wilton, D. P.: Central America Res. Sta., Bureau of Trop. Diseases, Cent. for Disease Control, Public Health Service. U.S. Dep. of Health, Education and Welfare, San Salvador, El Salvador, C.A.
N1 - Accession Number: 19770839464. Publication Type: Journal Article. Language: English. Language of Summary: German. Subject Subsets: Helminthology; Medical & Veterinary Entomology
N2 - The effectiveness of a mass separation technique was tested as a means of recovering infective-stage larvae of Onchocerca volvulus from Simulium ochraceum in Guatemala. Blood-engorged flies, collected from 10 infected human attractants, were maintained for 9 days to allow ingested microfilariae to develop to the infective stage. The numbers of Onchocerca larvae recovered after groups of these flies were crushed and washed into tissue culture fluid in Baermann funnels was compared with the numbers obtained by individual dissections of flies fed on the same subjects. The mass separation procedure gave a mean recovery rate of 0.03 larva/fly and detected larvae only in flies which had fed on those subjects with the highest microfilarial skin densities. Dissections yielded 0.50 larva/fly and detected larvae in flies collected from all test subjects. The explanation for the ineffectiveness of the mass separation technique may lie in the observed sluggishness of infective-stage Onchocerca larvae and a consequent inability to free themselves from the fly fragments in the Baermann funnel. [AS]<new para>ADDITIONAL ABSTRACT:<new para>The effectiveness of a mass separation technique that was described by L.R. Ash & J.M. Riley and L.R. Ash & J.F. Schacher for extracting filarial worms from mosquitoes was tested as a means for recovering infective-stage larvae of Onchocerca volvulus from Simulium ochraceum Wlk. in Guatemala. Blood-engorged flies, collected from 10 infected men, were maintained for 9 days to allow ingested microfilariae to develop to the infective stage. The numbers of larvae of O. volvulus recovered after groups of the flies were crushed and washed into tissue culture fluid in Baermann funnels averaged 0.03/fly, as compared with 0.50/fly by dissection. The mass separation technique yielded larvae only from flies that had fed on subjects with the highest microfilarial skin densities, but dissection yielded them even at the lowest densities. It is suggested that the ineffectiveness of the mass separation technique may result from the observed sluggishness of the infective-stage larvae and a consequent inability to free themselves from the fly fragments in the Baermann funnel.
KW - helminths
KW - larvae
KW - parasites
KW - recovery
KW - techniques
KW - Diptera
KW - Insects
KW - Nematoda
KW - Onchocerca volvulus
KW - Simuliidae
KW - Simulium ochraceum
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Diptera
KW - Simulium
KW - Simuliidae
KW - blackflies
KW - buffalo gnats
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770839464&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Persistence of poliovirus 1 in soil and on vegetables grown in soil previously flooded with inoculated sewage sludge or effluent.
AU - Tierney, J. T.
AU - Sullivan, R.
AU - Larkin, E. P.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1977///
VL - 33
IS - 1
SP - 109
EP - 113
SN - 0099-2240
AD - Tierney, J. T.: Virology Branch, Division of Microbiology, Bureau of Foods, Food and Drug Administration, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19771932483. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Soils & Fertilizers
N2 - During two summers in which lettuce and radish were grown on field plots and during one winter, the longest time for which poliovirus 1 survived in soil that had been flooded to a depth of 1 inch (2.54 cm) with sewage wastes inoculated with the virus was in winter, when the virus was detected after 96 days. During summer, the longest survival period was 11 days.
KW - irrigation water
KW - public health
KW - sewage effluent
KW - wastes
KW - poliovirus
KW - viruses
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Human Wastes and Refuse (XX300)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Fertilizers and other Amendments (JJ700)
KW - Soil Biology (JJ100)
KW - Soil Management (JJ900)
KW - Soil Water Management (Irrigation and Drainage) (JJ800) (Revised June 2002) [formerly Soil Water Management]
KW - Engineering and Equipment (General) (NN000)
KW - Wastes (General) (XX000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771932483&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of Echinococcus granulosus and other cestodes in dogs on the Navajo Reservation in Arizona and New Mexico.
AU - Schantz, P. M.
AU - Alstine, C. van
AU - Blacksheep, A., Jr.
AU - Sinclair, S.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 1977///
VL - 38
IS - 5
SP - 669
EP - 670
SN - 0002-9645
AD - Schantz, P. M.: Diseases Div., Bureau of Epidemiology, Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, Go. 30333, USA.
N1 - Accession Number: 19770834994. Publication Type: Journal Article. Language: English. Registry Number: 63-75-2. Subject Subsets: Helminthology; Veterinary Science
N2 - Of 429 dogs purged with arecoline hydrobromide at 131 rural camps on the Navajo Reservation in Arizona and New Mexico, USA, during June and July, 1975, 3 dogs at 3 different camps passed Echinococcus granulosus. The other cestodes found were Taenia hydatigena (in 45.5%), T. pisiformis (21.0%), T. serialis (11.9%) and T. ovis (1.6%). Serotesting of 8 human residents of 2 camps containing dogs infected with E. granulosus gave negative results.
KW - Arecoline
KW - epidemiology
KW - helminths
KW - parasites
KW - surveys
KW - Zoonoses
KW - Mountain States of USA
KW - USA
KW - DOGS
KW - Echinococcus
KW - Echinococcus granulosus
KW - Man
KW - Taenia
KW - Taeniidae
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Cyclophyllidea
KW - parasitic worms
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19770834994&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of various methods for the extraction of total lipids, fatty acids, cholesterol, and other sterols from food products.
AU - Hubbard, W. D.
AU - Sheppard, A. J.
AU - Newkirk, D. R.
AU - Prosser, A. R.
AU - Osgood, T.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1977///
VL - 54
IS - 2
SP - 81
EP - 83
SN - 0003-021X
AD - Hubbard, W. D.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771455574. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The sample is homogenized for about 2 min with about 20 times its weight of chloroform and methanol (Folch et al., NAR 28, 78), and filtered. The extract is washed with 20% of its volume of water and the CHCl3 layer is separated. The water layer is washed twice more with solvent, the solvent layers are combined and solvent is evaporated. This was the best of 7 methods for extracting lipid.
KW - cholesterol
KW - fatty acids
KW - lipids
KW - separation
KW - sterols
KW - lipins
KW - separating
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771455574&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - In vitro assessment of zinc bioavailability from protein foods.
AU - Jones, A. O. L.
AU - Fox, M. R. S.
T2 - Poultry Science
JO - Poultry Science
JF - Poultry Science
Y1 - 1977///
VL - 56
IS - 5
SP - 1727
EP - 1727
SN - 0032-5791
AD - Jones, A. O. L.: Division of Nutrition, HFF-268, Food and Drug Administration, 200 C St., S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19781472416. Language: English. Registry Number: 7440-66-6. Subject Subsets: Animal Nutrition; Human Nutrition
KW - availability
KW - estimation
KW - in vitro
KW - plant proteins
KW - protein
KW - vegetables
KW - zinc
KW - analysis of zinc bioavailability from protein in vitro
KW - vegetable crops
KW - Techniques and Methodology (ZZ900)
KW - Feed Composition and Quality (RR300)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781472416&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gastric cancer: current status of treatment.
AU - Carter, S. K.
AU - Comis, R. L.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1977///
VL - 58
IS - 3
SP - 567
EP - 578
SN - 0027-8874
AD - Carter, S. K.: Division of Cancer Treatment, National Cancer Inst., Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19771459124. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Subject Subsets: Human Nutrition
N2 - Although carcinoma of the stomach is decreasing in incidence in the USA, it is still the most common cause of cancer death. Gastric neoplasms are not decreasing in other geographical areas; in the USSR, 30% of all cancer originates in the stomach and in Japan the rate of gastric neoplasms is greatest with over 54% of all cancer in the male population arising in the stomach. The peak age for development of stomach cancer is between 70 and 80 years; over 60% of all stomach cancer is diagnosed in patients between 60 and 70 years old, while more than 10% occurs in those over 80. Surgical treatment is the main cure. Results with the drugs commonly used to treat gastric cancer, 5-fluorouracil and mitomycin C, are discussed; those with the nitrosoureas, adriamycin and other drugs are reviewed.
KW - drugs
KW - neoplasms
KW - stomach
KW - Japan
KW - USA
KW - USSR
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - North America
KW - America
KW - cancers
KW - incidence, surgical and drug treatment of gastric cancer
KW - medicines
KW - pharmaceuticals
KW - Union of Soviet Socialist Republics
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771459124&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contribution of the environment to cancer incidence: an epidemiologic exercise.
AU - Wynder, E. L.
AU - Gori, B. G.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1977///
VL - 58
IS - 4
SP - 825
EP - 832
SN - 0027-8874
AD - Wynder, E. L.: Division of Cancer Cause and Prevention, National Cancer Inst., Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19771459126. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Subject Subsets: Human Nutrition
N2 - Differences in mortality and incidence rates for major types of cancer between population groups, sex ratios, time trends and demographic and socioeconomic variables are examined. It is concluded that environmental carcinogens can be categorized as those related to personal life style (which include alcohol and nutritional imbalances) and general environmental factors (which include water pollution and food additives as contaminants). Preventive measures are discussed.
KW - drinking water
KW - food additives
KW - neoplasms
KW - cancers
KW - drinking water pollution, food additives and cancer incidence
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Additives (QQ130)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771459126&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin A contents of rat intestinal epithelium and jejunal mucinous adenocarcinoma.
AU - Sundaresan, P. R.
AU - Luca, L. M. De
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1977///
VL - 58
IS - 6
SP - 1643
EP - 1645
SN - 0027-8874
AD - Sundaresan, P. R.: Experimental Pathology Branch, National Cancer Inst., National Inst. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19771460873. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition
N2 - Retinol and retinyl esters were estimated in intestinal mucosa of F344 rats and in chemically induced transplanted mucinous adenocarcinoma of the jejunum. Lipid extract from the tissues was chromatographed on deactivated alumina to isolate retinol and retinyl esters, which were estimated by specific spectrofluorometry. Normal intestinal mucosa tissue had retinol equivalents as retinyl esters 556 and free retinol 303 ng/g wet tissue. The concentration of retinyl esters in intestinal mucosa of rats carrying the transplanted tumour was 341 ng/g wet tissue; no free retinol was detected in the small intestinal epithelium of those rats. Liver tissue from the tumour-bearing rats had retinol equivalents as retinyl esters 157 and free retinol 136 mu g/g wet tissue. In the adenocarcinoma tissue there was about 20 times less vitamin A/cell than in intestinal epithelium.
KW - intestinal mucosa
KW - jejunum
KW - neoplasms
KW - RETINOL
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - cancers
KW - intestine epithelium
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A in intestinal epithelium, liver and jejunal adenocarcinoma
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771460873&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relation between quantities of lead ingested and health effects of lead in humans.
AU - Mahaffey, K. R.
JO - Pediatrics, USA
JF - Pediatrics, USA
Y1 - 1977///
VL - 59
IS - 3
SP - 448
EP - 456
AD - Mahaffey, K. R.: Division of Nutrition, Food and Drug Administration, US Dep. Health, Education and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771459401. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Major metabolic effects of Pb are briefly reviewed and data on quantitative relations between Pb ingestion and development of toxicity in adults and children are discussed. Levels of Pb ingestion producing clinical toxicity in adults are compared with normal levels of exposure. For children, comparison of levels of Pb ingestion and quantities of Pb producing toxic effects is not possible, as information on levels of lead producing clinical toxicity is highly variable because of the small amount of data available. Recommendations on tolerable levels of Pb exposure for children are proposed, based on estimates of Pb exposure for children with normal and increased body burdens of Pb.
KW - lead
KW - tolerance and toxicity
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771459401&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of finfish and shellfish for volatile N-nitrosamines.
AU - Havery, D. C.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 3
SP - 517
EP - 519
AD - Havery, D. C.: Food and Drug Administration, Division of Chemistry and Physics, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771458687. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - No nitrosamines were detected in 78 samples, comprising 7 varieties of fish and 19 of shellfish, purchased on the local retail market.
KW - fish
KW - nitrosamines
KW - shellfish
KW - nitrosamines in fish and shellfish
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Aquatic Produce (QQ060)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771458687&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamins and other nutrients. Assay of thiamine in foods, using manual and semiautomated fluorometric and microbiological methods.
AU - Defibaugh, P. W.
AU - Smith, J. S.
AU - Weeks, C. E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 3
SP - 522
EP - 527
AD - Defibaugh, P. W.: Food and Drug Administration, Division of Nutrition, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771458688. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 59-43-8. Subject Subsets: Human Nutrition
N2 - The recovery of added thiamin from 14 processed food was 91.2 and 99.3%, respectively, using manual and semiautomated fluorescent methods. For 8 of these, values were 90.7 plus or minus 9.0, 101 plus or minus 2.5 and by estimation with Lactobacillus viridescens 99.9 plus or minus 1.0%. The last method gave best results. The semiautomated method was rapid and accurate.
KW - estimation
KW - thiamin
KW - aneurin
KW - thiamine
KW - vitamin B1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771458688&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins. Aflatoxin and zearalenone occurrence in dry-milled corn products.
AU - Stoloff, L.
AU - Dalrymple, B.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 3
SP - 579
EP - 582
AD - Stoloff, L.: Food and Drug Administration, Division of Chemistry and Physics, Washington, D.C. 20204, USA.
N1 - Accession Number: 19771458692. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - Control practices for preventing the use of contaminated maize were studied in 82 dry-milling establishments. Zearalenone was not detected in any product. Aflatoxin contamination was correlated with the geographical source of the maize but not with the control practices. The distribution of aflatoxin between maize and its products as reported by Brekke et al. (NAR 46, 2780) was confirmed.
KW - aflatoxins
KW - maize
KW - mycotoxins
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - aflatoxin and zearalenone in maize
KW - corn
KW - fungal toxins
KW - zearalenone content
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771458692&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of semiautomated and manual methods for the determination of thiamine in baby cereals and infant and dietary formulas.
AU - Ribbron, W. M.
AU - Stevenson, K. E.
AU - Kirk, J. R.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 3
SP - 737
EP - 738
AD - Ribbron, W. M.: Food and Drug Administration, 1560 E Jefferson Ave., Detroit, MI 48207, USA.
N1 - Accession Number: 19771458704. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 59-43-8. Subject Subsets: Human Nutrition
N2 - The modified semiautomated method of Kirk (NAR 45, 6438) gave values for thiamin in infant foods 83 to 101% of those obtained with the AOAC manual method. Results were best when data from the former method were calculated from a standard curve obtained by using thiamin solutions digested and hydrolysed with the samples.
KW - infant foods
KW - thiamin
KW - aneurin
KW - baby foods
KW - estimation of thiamin in infant foods
KW - thiamine
KW - vitamin B1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771458704&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid digestion and flameless atomic absorption spectroscopy of mercury in fish: collaborative study.
AU - Munns, R. K.
AU - Holland, D. C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 4
SP - 833
EP - 837
AD - Munns, R. K.: Food and Drug Administration, 20th and California Sts, Denver, CO 80202, USA.
N1 - Accession Number: 19771461179. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7439-97-6. Subject Subsets: Human Nutrition; Veterinary Science
N2 - Hg was estimated in tuna digested with H2SO4 and HNO3 (1:1) and V2O5 as catalyst. The method was as precise and accurate as the AOAC official digestion technique and was more rapid and less hazardous. It was adopted as official first action.
KW - FISH
KW - mercury
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - estimation of mercury in tuna fish
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771461179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modification of Canadian Food and Drug Directorate lipoxidase method for polyunsaturated fatty acid determination.
AU - Prosser, A. R.
AU - Sheppard, A. J.
AU - Hubbard, W. D.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 4
SP - 895
EP - 898
AD - Prosser, A. R.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19771461184. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - An adaptation of MacGee's method (NAR 29, 3554) was modified to meet the needs of the cholesterol and fatty acid regulations of the US Food and Drug Administration.
KW - estimation
KW - unsaturated fatty acids
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771461184&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fluorometric determination of histamine in tuna: development of method.
AU - Staruszkiewicz, W. F., Jr.
AU - Waldron, E. M.
AU - Bond, J. F.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 5
SP - 1125
EP - 1130
AD - Staruszkiewicz, W. F., Jr.: Food and Drug Administration, Division of Food Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19771463801. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 51-45-6. Subject Subsets: Human Nutrition
N2 - A methanol extract of tuna was treated with an anion-exchange resin to remove interfering materials. The reaction of histamine with o-phthalaldehyde gave a highly fluorescent derivative which was estimated. In a 100-g sample less than 10 mg histamine can be estimated. The method was as accurate and precise as the official AOAC colorimetric method.
KW - analysis
KW - fish
KW - histamine
KW - tuna
KW - Scombridae
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771463801&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fluorometric determination of histamine in tuna: collaborative study.
AU - Staruszkiewicz, W. F., Jr.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1977///
VL - 60
IS - 5
SP - 1131
EP - 1136
AD - Staruszkiewicz, W. F., Jr.: Food and Drug Administration, Division of Food Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19771463802. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 51-45-6. Subject Subsets: Human Nutrition
N2 - The official AOAC method and a fluorometric method (see previous abst.) were used. Similar results were obtained and the fluorometric method of estimating histamine in tuna was adopted as official first action.
KW - analysis
KW - fish
KW - histamine
KW - tuna
KW - Scombridae
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19771463802&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exotic diseases - ounce of prevention or pound of cure.
AU - Schultz, M. G.
JO - Postgraduate Medicine
JF - Postgraduate Medicine
Y1 - 1977///
VL - 62
IS - 2
SP - 121
EP - 142
SN - 0032-5481
AD - Schultz, M. G.: Parasitic Diseases Div., Bureau of Epidemiology, Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19780845229. Publication Type: Journal Article. Language: English. Subject Subsets: Leisure, Recreation, Tourism; Protozoology; Helminthology
N2 - This is a useful general account of the infections to which travellers may be exposed, prophylactic measures which can be taken, sources of more detailed information and diagnosis. Among the protozoa, some information is given on Plasmodium, especially P. falciparum, and Giardia, amoebiasis, leishmaniasis and trypanosomiasis are mentioned.<new para>ADDITIONAL ABSTRACT:<new para>This is a useful general account of the infections to which travellers may be exposed, prophylactic measures which can be taken, sources of more detailed information and diagnosis. The helminths mentioned are schistosomes, Trichinella, filariids, tapeworms, liver-flukes, Strongyloides, Ascaris and Trichostrongylus.
KW - epidemiology
KW - helminths
KW - parasites
KW - prophylaxis
KW - travel
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - general account
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780845229&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumer nutrition knowledge and self reported food shopping behavior.
AU - Fusillo, A. E.
AU - Beloian, A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977///
VL - 67
IS - 9
SP - 846
EP - 850
SN - 0090-0036
AD - Fusillo, A. E.: Div. Consumer Studies, Food and Drug Administration, Dep. Health, Education and Welfare, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19781472716. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - In 1975 a national sample of 2333 consumers in the USA was questioned about their knowledge of nutrition, beliefs about food and their shopping behaviour. The findings indicated a particular lack of knowledge about Fe, thiamin, riboflavin and vitamins A and D. Those with little knowledge tended to have less education, lower incomes and less prestigious occupations. Of these variables, education had the strongest association with low knowledge of nutrition. With the index based on the 3 socioeconomic variables, low knowledge was most often shown among the male and older shoppers, age having the stronger association. Associations of the 3 indices of nutrition knowledge, food beliefs and reported shopping behaviour were positive and linear.
KW - food purchasing
KW - nutrition education
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutrition knowledge and food shopping behaviour
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781472716&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Specific diagnosis of foodborne disease.
AU - Horwitz, M. A.
JO - Gastroenterology
JF - Gastroenterology
Y1 - 1977///
VL - 73
IS - 2
SP - 375
EP - 381
SN - 0016-5085
AD - Horwitz, M. A.: Enteric Diseases Branch, Bacteria Diseases Div., Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education & Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19780851002. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Helminthology; Protozoology; Dairy Science
N2 - The commonly reported foodborne diseases in the USA are differentiated clinically by their median incubation period, predominant symptomatology and median duration of illness and epidemiologically by their transmission, geographical location and seasonal predilections. Laboratory tests are recommended for confirmation of the diagnosis. Trichinella spiralis and Toxoplasma gondii are included among the aetiological agents.<new para>ADDITIONAL ABSTRACT:<new para>The commonly reported foodborne diseases are differentiated by their incubation period, predominant symptoms, duration of illness, vehicle of transmission, geographic locations, and season in which the disease occurs. Laboratory tests are recommended for confirmation of diagnoses.
KW - diagnosis
KW - diseases
KW - food
KW - helminths
KW - parasites
KW - reviews
KW - USA
KW - Enoplida
KW - man
KW - protozoa
KW - Toxoplasma gondii
KW - Trichinella spiralis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - Trichinella
KW - Trichinellidae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Nematoda
KW - Enoplia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Adenophorea
KW - borne
KW - milk-borne diseases
KW - nematodes
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780851002&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current concepts in parasitology. Parasitic diseases.
AU - Schultz, M. G.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1977///
VL - 297
IS - 23
SP - 1259
EP - 1261
SN - 0028-4793
AD - Schultz, M. G.: Parasitic Diseases Div., Bureau of Epidemiology, Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta GA 30333, USA.
N1 - Accession Number: 19780842435. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Protozoology
N2 - The extent, distribution and the cost of human infection with schistosomiasis, malaria, trypanosomiasis, leishmaniasis, filariasis, Ascaris, Trichuris and hookworm are discussed. Schultz stresses that although these diseases are most prevalent in developing countries, American physicians should concern themselves with them because of the rising incidence of importation, the potential for biomedical research and the responsibility of developed countries to help the developing ones.
KW - filariids
KW - helminths
KW - hookworms
KW - parasites
KW - Ascaris
KW - Enoplida
KW - Leishmania
KW - man
KW - Plasmodium
KW - protozoa
KW - Schistosoma
KW - Trichuris
KW - Trypanosoma
KW - Ascarididae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - Trichuridae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Enoplia
KW - Adenophorea
KW - Ascaridida
KW - Haemosporida
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780842435&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The experimental infection of Anopheles litoralis King from Luzon Island, Philippines, by Plasmodium vivax.
AU - Darsie, R. F., Jr.
AU - Cagampang-Ramos, A.
AU - Kalaw, F.
JO - Southeast Asian Journal of Tropical Medicine and Public Health
JF - Southeast Asian Journal of Tropical Medicine and Public Health
Y1 - 1978///
VL - 9
IS - 3
SP - 445
EP - 445
SN - 0125-1562
AD - Darsie, R. F., Jr.: Central America Res. Sta., Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, US Dep. of Health Education & Welfare, San Salvador, El Salvador, Central America.
N1 - Accession Number: 19790855451. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Female Anopheles litoralis derived from females caught on Luzon Island, Philippines, were fed on a patient with 2000 Plasmodium vivax/mm3 of blood, of which 2% were mature female and 1% mature male gametocytes. One of 11 mosquitoes still alive after 15 days was heavily infected with sporozoites in the salivary glands.
KW - epidemiology
KW - experimental infection
KW - parasites
KW - Anopheles litoralis
KW - Culicidae
KW - insects
KW - Plasmodium vivax
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790855451&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent advances in the diagnosis of hydatidosis (1970-1976).
AU - Kagan, I. G.
JO - Parasitologia Hungarica
JF - Parasitologia Hungarica
Y1 - 1978///
VL - 11
SP - 31
EP - 50
SN - 0303-688X
AD - Kagan, I. G.: Center for Disease Control, Public Health Service, U.S., Dep. of Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19790856542. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - The immunological diagnosis of hydatid infection in man is reviewed. Each diagnostic test is briefly considered separately, together with an annotated list of the recent literature on that test. All 144 references are listed in full at the end of the paper.
KW - helminths
KW - hydatids
KW - IMMUNODIAGNOSIS
KW - immunology
KW - parasites
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - parasitic worms
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790856542&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation on serologic tests for studies on Chagas' disease.
AU - Kagan, I. G.
AU - Goldsmith, R. S.
AU - Zarate-Castaneda, R.
AU - Allain, D. S.
JO - Bulletin of the Pan American Health Organization
JF - Bulletin of the Pan American Health Organization
Y1 - 1978///
VL - 12
IS - 4
SP - 341
EP - 348
SN - 0085-4638
AD - Kagan, I. G.: Parasit. Div., Public Health Service, US Dep. of Health, Education, & Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19790854452. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Three serological tests for infection with Trypanosoma cruzi were compared using sera collected in Oaxaca, Mexico. Indirect haemagglutination (IHA) on 44 samples repeated a second time showed 95% agreement. IHA and complement fixation (CF) on 150 sera showed 81% agreement. IHA and direct agglutination (DA) on 98 sera showed 98% agreement. When T. rangeli was used as antigen, 27 sera tested by IHA gave few or no positive results. 85 sera were tested against T. cruzi by IHA and against Leishmania mexicana antigen by DA; 9 (11%) were positive to both tests and 41 were positive with T. cruzi but negative with L. mexicana. Sera from 128 subjects were tested directly by IHA and also as eluates from dried blood on filter papers; there was 93% agreement in results, showing that the filter paper technique is a reliable method of obtaining specimens.
KW - IMMUNODIAGNOSIS
KW - immunology
KW - parasites
KW - Mexico
KW - Leishmania mexicana
KW - man
KW - protozoa
KW - Trypanosoma cruzi
KW - Trypanosoma rangeli
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Trypanosoma
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - serological cross reactions
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790854452&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological evaluation of isomers of N-acetyl-methionine and methionine in young rats.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
AU - Valentine, H.
AU - Boyd, Z. J.
AU - Adkins, J. S.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1978///
VL - 17
IS - 3
SP - 377
EP - 386
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781470741. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 63-68-3. Subject Subsets: Human Nutrition
N2 - Male Holtzman rats initially 21 days old and weighing 45 to 51 g were given to appetite for 28 days a diet with about 15% soya bean protein concentrate without or with 0.224% D-methionine, L-methionine or DL-methionine or 0.289% N-acetyl-D-methionine, Nacetyl-L-methionine or N-acetyl-DL-methionine. Weight gain for controls was 72 g and protein efficiency ratio (PER) was 2.78. For the other groups, weight gain was from 92 to 141 g and PER from 3.18 to 4.07. All on the supplemented diets, except those given N-acetyl-D-methionine, had kidneys and testes which weighed less as a percentage of bodyweight and more plasma albumin and liver N than the controls. Hb value was similar in all groups. Rats given N-acetyl-D-methionine had urea N 20 mg/100 ml blood compared with 12 mg/100 ml for controls and 11 to 15 mg/100 ml for the other groups.
KW - methionine
KW - nutritive value
KW - protein
KW - soya protein
KW - vegetables
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - methionine and its isomers on biological value of soya protein diet
KW - nutritional value
KW - quality for nutrition
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - vegetable crops
KW - Physiology of Human Nutrition (VV120)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781470741&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of long-term restriction of protein intake, from gestation onward, on free-choice consumption of ethanol by rats.
AU - Hanig, J. P.
AU - Yoder, P.
AU - Krop, S.
AU - Lao, C.
JO - Life Sciences
JF - Life Sciences
Y1 - 1978///
VL - 23
IS - 3
SP - 275
EP - 281
SN - 0024-3205
AD - Hanig, J. P.: Bureau of Drugs, Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781476503. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition
N2 - Rats on a diet with 8% protein for 76 days during gestation and lactation drank less ethanol when given a choice of 6% ethanol or water than rats on a diet of equal energy with 24% protein. The difference disappeared in 2 subsequent periods of 100 days.
KW - ethanol
KW - protein deprivation
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ethanol intake in protein deprivation
KW - ethyl alcohol
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781476503&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual lipid and proximate analysis of various foods. 3. Potato chips and corn snack foods.
AU - Sheppard, A. J.
AU - Smith, L. M.
AU - Hubbard, W. D.
AU - Newkirk, D. R.
AU - Dunkley, W. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1978///
VL - 26
IS - 2
SP - 346
EP - 348
SN - 0021-8561
AD - Sheppard, A. J.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781470627. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Horticultural Science; Human Nutrition
N2 - 3. Values are tabulated for water, protein, ash, fat, sterols, fatty acids and cis,cis-methylene interrupted polyunsaturated triglycerides in 20 brands of potato chips, corn puffs and corn chips. There was considerable variation among brands in fatty acid and sterol contents indicating use of vegetable and animal fats. Chips contained total fat 30 to 43 and corn snack foods 16 to 63%.
KW - lipids
KW - maize
KW - potatoes
KW - Solanum tuberosum
KW - Zea mays
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - corn
KW - lipids in potato and corn chips and puffs
KW - lipins
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781470627&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual lipids and proximate analysis of various foods. 2. Frankfurters and other meat and poultry products.
AU - Newkirk, D. R.
AU - Sheppard, A. J.
AU - Hubbard, W. D.
AU - Osgood, T.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1978///
VL - 26
IS - 2
SP - 348
EP - 350
SN - 0021-8561
AD - Newkirk, D. R.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781470626. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition
N2 - 2. Values are tabulated for water, protein, ash, fat, cholesterol, other sterols and fatty acids in frankfurters (9 types) and meat and poultry products (16). Values per 100 g were fat 2.0 to 30.2 g, polyunsaturated fatty acids 0.1 to 6.1 g and cholesterol 7 to 100mg.[See also NAR/A 48, 5005.]
KW - lipids
KW - meat products
KW - poultry meat
KW - sausages
KW - lipids in meat and poultry products
KW - lipins
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781470626&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual lipids and proximate analysis of various foods. 4. Commercial cake mixes.
AU - Rudolf, T. S.
AU - Hubbard, W. D.
AU - Newkirk, D. R.
AU - Sheppard, A. J.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1978///
VL - 26
IS - 4
SP - 842
EP - 844
SN - 0021-8561
AD - Rudolf, T. S.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781477990. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition
N2 - For parts 2 and 3 see NAR 48/A, 7981, 7982.4. Values are tabulated for water, protein, ash, total fat, 4 sterols and fatty acids in 18 types of cake mix. Results indicate that vegetable oil alone or mixed with animal fat was used. Fat ranged from 8.2 to 15.3% and cholesterol from 0 to 22 mg/100 g.
KW - bakery products
KW - lipids
KW - baked goods
KW - lipids in bakery products
KW - lipins
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781477990&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Limitations of the intradermal test for schistosomiasis mansoni: experience from epidemiologic studies in a Puerto Rican community.
AU - Hiatt, R. A.
AU - Cline, B. L.
AU - Knight, W. B.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1978///
VL - 27
IS - 3
SP - 535
EP - 541
SN - 0002-9637
AD - Hiatt, R. A.: San Juan Lab., Bureau of Labs., Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, GPO Box 4532, San Juan, Puerto Rico 00936.
N1 - Accession Number: 19780848978. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - The intradermal reaction with Schistosoma mansoni adult worm antigen was assessed in an endemic Puerto Rican community where the prevalence of S. mansoni infection was 36% and the geometric mean egg count was 17.6 epg. Of 296 persons tested 43% were positive by intradermal test compared with 48% by faecal examination. The sensitivity was low at 36% for children and only 73 to 79% for adults. The test was very specific for children (96%), but 32% of adults negative by faecal examination, were positive. The mean wheal area was not directly related to the intensity of infection as determined by egg counts in either children or adults, but it did increase directly with age. Mean wheal areas were greater for males than for females at all intensities of infection.
KW - diagnosis
KW - helminths
KW - IMMUNODIAGNOSIS
KW - immunology
KW - parasites
KW - skin tests
KW - Puerto Rico
KW - man
KW - Schistosoma mansoni
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - intradermal tests
KW - parasitic worms
KW - Porto Rico
KW - serological diagnosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780848978&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Schistosoma mansoni infection in intact and B cell deficient mice: the effect of pretreatment with BCG in these experimental models.
AU - Maddison, S. E.
AU - Chandler, F. W.
AU - McDougal, J. S.
AU - Slemenda, S. B.
AU - Kagan, I. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1978///
VL - 27
IS - 5
SP - 966
EP - 975
SN - 0002-9637
AD - Maddison, S. E.: Parasit. & Path. Div., Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19780851929. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology; Veterinary Science
N2 - The course of infection with Schistosoma mansoni was determined in B cell-deficient mice (prepared from CBA and NMRI strains) by means of a schistosomule lung recovery assay 6 days after infection or by determination of the adult worm burden 7 weeks after infection. There was no significant difference in infection intensity between intact controls and B cell-deficient mice. B cell deficiency was demonstrated by absence of surface immunoglobulin-bearing cells in the spleen and by absence of B cell areas in the lymphoid follicles of the spleen and mesenteric lymph nodes. In additon B cell deficient mice infected for 7 weeks with S. mansoni were unable to form anti-schistosome antibodies detectable by the Cercarienhullenreaktion. A normal granulomatous response, however, was observed around schistosome eggs. Pretreatment with BCG suppressed infection with S. mansoni comparably in intact and B cell deficient mice. A marked depletion of eosinophils occurred in the schistosome egg granuloma of all BCG treated mice. [AS]
KW - B lymphocytes
KW - helminths
KW - immunology
KW - Nonspecific immunostimulation
KW - parasites
KW - MICE
KW - Mycobacterium tuberculosis
KW - Rodents
KW - Schistosoma
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Schistosoma
KW - B cells
KW - B-cell deficiency
KW - bacterium
KW - nonspecific immunopotentiation
KW - parasitic worms
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780851929&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Giardiasis in American travelers to Madeira island, Portugal.
AU - Lopez, C. E.
AU - Juranek, D. D.
AU - Sinclair, S. P.
AU - Schultz, M. G.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1978///
VL - 27
IS - 6
SP - 1128
EP - 1132
SN - 0002-9637
AD - Lopez, C. E.: Parasit. Dis. Div., Bureau of Epidem., Center for Dis. Control, Public Health Service, US Dep. of Health, Education, and Welfare, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19790855272. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - A high incidence of diarrhoea was reported in a group of approximately 1400 Americans who travelled to Madeira in October 1976. A mail questionnaire survey revealed that 39% of the responding 859 travellers experienced diarrhoea; in 42% of these diarrhoea lasted for longer than one week. The most frequent accompanying symptoms were abdominal cramps (75%), abdominal distention (72%), nausea (70%), and weight loss (40%). Of all travellers surveyed, 33% developed an illness resembling giardiasis with a median incubation period of 4 days. Of 35 ill patients who had a stool culture, enteric pathogens were recovered from 4 (3 Shigella and one Salmonella). On the other hand, of 58 ill patients whose stools were examined for parasites, Giardia lamblia was recovered from 27. Epidemiological data showed that drinking tap-water on the island was significantly associated with illness; eating ice cream or raw vegetables on the island was also implicated. There was no evidence of continuing transmission of giardiasis in American tourists visiting Madeira 8 to 12 months after the outbreak. [AS]
KW - epidemiology
KW - imported infections
KW - parasites
KW - travel
KW - Madeira
KW - USA
KW - Giardia duodenalis
KW - man
KW - protozoa
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Atlantic Ocean Islands
KW - Portugal
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - APEC countries
KW - North America
KW - America
KW - Giardia lamblia
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790855272&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aedes aegypti in Puerto Rico: environmental determinants of larval abundance and relation to dengue virus transmission.
AU - Moore, C. G.
AU - Cline, B. L.
AU - Ruiz-Tiben, E.
AU - Lee, D.
AU - Romney-Joseph, H.
AU - Rivera-Correa, E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1978///
VL - 27
IS - 6
SP - 1225
EP - 1231
SN - 0002-9637
AD - Moore, C. G.: San Juan Laboratories, Public Health Service, US Department of Health, Education and Welfare, San Juan, Puerto Rico 00922, USA.
N1 - Accession Number: 19790562285. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - In order to understand adequately the dynamics of vector-borne disease, the reasons how and why vector populations change over time must be understood. A long-term cooperative study of seasonal fluctuation in populations of Aedes aegypti (L.) in Puerto Rico is described. During each month of the first 3 years of the project, A. aegypti was found breeding in all 5 communities studied. Mosquito density was positively correlated with rainfall, the relationship being more marked in the dry south-coastal part of the island. Discarded tyres and animal watering pans were the two most common larval breeding sites. In general, houses in Puerto Rico harboured more potential A. aegypti breeding sites than those in other tropical locations, probably because Puerto Rico is relatively more affluent.
KW - dwellings
KW - mosquito nets
KW - population dynamics
KW - tyres
KW - Puerto Rico
KW - Aedes aegypti
KW - Culicidae
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - drinking pans
KW - mosquitoes
KW - Porto Rico
KW - tires
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Other Control Measures (HH700)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790562285&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunoreactive glucagon responses to oral glucose, insulin infusion and deprivation, and somatostatin in pancreatectomized man.
AU - Werner, P. L.
AU - Palmer, J. P.
JO - Diabetes
JF - Diabetes
Y1 - 1978///
VL - 27
IS - 10
SP - 1005
EP - 1012
AD - Werner, P. L.: Diabetes Research Center, US Public Health Service Hospital, 1131-14th Ave. South, Quarters 8, Seattle, Wash. 98144, USA.
N1 - Accession Number: 19791483866. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 9004-10-8, 51110-01-1, 9007-92-5, 50-99-7. Subject Subsets: Human Nutrition
N2 - In a group of pancreatectomized subjects, immunoreactive glucagon (IRG) concentrations in plasma were normal after an overnight fast, increased after glucose by mouth, were not suppressed by somatostatin (SRIF) or insulin and, in 2 of 4 subjects, they rose with an arginine infusion. Even though the SRIF infusion did not decrease IRG, there was a fall in plasma glucose concentration in both subjects. In 2 subjects, endogenous hyperglycaemia occurred during insulin withdrawal with no rise in IRG and, in one subject, mild diabetic ketoacidosis developed with only a slight rise in IRG. The results support the presence of an extrapancreatic source of IRG in man. Secretion from these extrapancreatic alpha cells seems to be regulated differently from that from pancreatic alpha cells.
KW - glucagon
KW - glucose
KW - insulin
KW - pancreatectomy
KW - somatostatin
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - plasma glucagon after glucose, insulin or somatostatin after pancreatectomy
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791483866&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolic and turnover studies on retinol and retinoic acid.
AU - Sundaresan, P. R.
JO - World Review of Nutrition and Dietetics
JF - World Review of Nutrition and Dietetics
Y1 - 1978///
VL - 31
SP - 83
EP - 88
AD - Sundaresan, P. R.: Division of Toxicology, Bureau of Foods, Food and Drug Administration, Building FOB-8, Washington, DC 20204, USA.
N1 - Accession Number: 19801405253. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 302-79-4, 68-26-8. Subject Subsets: Human Nutrition
N2 - Trials were with rats.
KW - retinoic acid
KW - retinol
KW - turnover
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - tretinoin
KW - vitamin A
KW - vitamin A acid
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801405253&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effect of wheat bran on utilization of powdered metallic iron.
AU - Fritz, J. C.
AU - Pla, G. W.
AU - Clark, G. A.
T2 - Federation Proceedings
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1978///
VL - 37
IS - 3
SP - 488
EP - 488
SN - 0014-9446
AD - Fritz, J. C.: Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781472268. Language: English. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
KW - iron
KW - wheat bran
KW - wheat bran affects metallic iron utilization
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781472268&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effect of electrolytic iron on iron stores in the rat.
AU - Harrison, B. N.
AU - Fritz, J. C.
AU - Smith, E.
T2 - Federation Proceedings
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1978///
VL - 37
IS - 3
SP - 488
EP - 488
SN - 0014-9446
AD - Harrison, B. N.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781472269. Language: English. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
KW - iron
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - electrolytic iron on iron stores
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781472269&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Utilization of L-tyrosine ethyl ester HCl and methionine derivatives in young rats fed amino acid diets.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
T2 - Federation Proceedings
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1978///
VL - 37
IS - 3
SP - 537
EP - 537
SN - 0014-9446
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781471667. Language: English. Registry Number: 63-68-3, 60-18-4. Subject Subsets: Human Nutrition
KW - methionine
KW - tyrosine
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - utilization of tyrosine ethyl ester HCl and methionine derivatives
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781471667&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effects of various factors on bioavailability of elemental iron powders.
AU - Pla, G. W.
AU - Rollinson, C. L.
AU - Fritz, J. C.
T2 - Federation Proceedings
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1978///
VL - 37
IS - 3
SP - 893
EP - 893
SN - 0014-9446
AD - Pla, G. W.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781471976. Language: English. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
KW - iron
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - availability of elemental iron powders
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781471976&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food hazards of natural origin.
AU - Rodricks, J. V.
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1978///
VL - 37
IS - 12
SP - 2587
EP - 2593
SN - 0014-9446
AD - Rodricks, J. V.: Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781479096. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition
N2 - On the basis of source of chemical and route of entry into food 6 categories of natural origin that comprise or can become components of food are described. Known and expected human health risks from these compounds are discussed.
KW - foods
KW - toxins
KW - naturally occurring toxins in foods
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781479096&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Management of sludge use on land.
AU - Jelinek, C. F.
AU - Braude, G. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1978///
VL - 41
IS - 6
SP - 476
EP - 480
SN - 0362-028X
AD - Jelinek, C. F.: Bureau of Foods, Food and Drug Administration, Washington, D.C.20204, USA.
N1 - Accession Number: 19791945964. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Soils & Fertilizers
N2 - Concerns about contamination of food by pathogenic microorganisms, heavy metals, persistent pesticides and industrial chemicals such as polychlorinated biphenyls are described. Concerns about direct application of sludge onto growing food and feed crops are discussed. The estimated daily intake of lead and cadmium, as compared to the proposed tolerable daily intakes, is presented, together with the Food and Drug Administration's program to develop sufficient data on the natural background levels of these metals in raw agricultural products. Limitations recommended to prevent hazardous cadmium, lead, PCB and pathogen contaminations of food and feeds by sludge are presented.
KW - manures
KW - public health
KW - sewage sludge
KW - Fertilizers and other Amendments (JJ700)
KW - Animal Wastes (XX100)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Engineering and Equipment (General) (NN000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791945964&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health concerns relative to the use of subtherapeutic levels of antibiotics in animal feeds.
AU - Houweling, C. D. Van
AU - Gainer, J. H.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1978///
VL - 46
IS - 5
SP - 1413
EP - 1414
SN - 0021-8812
AD - Houweling, C. D. Van: Food and Drug Administration, Bureau of Veterinary Medicine, Rockville, MD 20852, USA.
N1 - Accession Number: 19781474665. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Animal Nutrition; Human Nutrition
KW - animal products
KW - antibiotics
KW - FEED SUPPLEMENTS
KW - public health
KW - public health hazard
KW - public health risks from subtherapeutic antibiotic levels in animal feeds
KW - Animal Nutrition (Production Responses) (LL520)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781474665&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pathogenesis of atherosclerosis. Concepts based on animal models.
AU - Kottke, B. A.
AU - Subbiah, M. T. R.
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
Y1 - 1978///
VL - 53
IS - 1
SP - 35
EP - 48
SN - 0025-6196
AD - Kottke, B. A.: National Heart, Lung and Blood Inst., Public Health Service, Bethesda, Md., USA.
N1 - Accession Number: 19781470193. Publication Type: Journal Article. Language: English. Number of References: 150 ref. Subject Subsets: Human Nutrition
KW - atherosclerosis
KW - laboratory animals
KW - arteriosclerosis
KW - concepts of atherosclerosis aetiology based on animal models
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781470193&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cancer incidence and mortality trends in the United States: 1935-74.
AU - Devesa, S. S.
AU - Silverman, D. T.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1978///
VL - 60
IS - 3
SP - 545
EP - 571
SN - 0027-8874
AD - Devesa, S. S.: Biometry Branch, National Cancer Inst., Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19781473262. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - From incidence data from 3 national cancer surveys and mortality data for all of USA observations are made concerning trends in cancer occurrence. Rates among males have been increasing, whereas those among females have been decreasing. In the past, cancer of all sites combined occurred more frequently among females; now males have rates higher than females of the same race. White predominance has been replaced by a nonwhite excess in incidence and mortality rates among males and a nonwhite excess in female mortality; racial differences in incidence rates among females have been diminishing.
KW - ethnicity
KW - neoplasms
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - ethnic differences
KW - secular and ethnic variations in cancer type, incidence and mortality in USA
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781473262&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Status report on saccharin in humans.
AU - Newell, G. R.
AU - Hoover, R. N.
AU - Kolbye, A. C., Jr.
T2 - Journal of the National Cancer Institute
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1978///
VL - 61
IS - 2
SP - 275
EP - 276
SN - 0027-8874
AD - Newell, G. R.: National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19791480178. Publication Type: Editorial. Language: English. Number of References: 14 ref. Registry Number: 81-07-2. Subject Subsets: Human Nutrition
N2 - From a review of existing epidemiological studies, it is concluded that there is not enough evidence to establish an association between use of artificial sweeteners, specifically saccharin, and increased risk of bladder cancer in man. A proposed new study by the National Cancer Institute and the Food and Drug Administration is described.
KW - BLADDER
KW - neoplasms
KW - reviews
KW - saccharin
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - review of saccharin and bladder cancer
KW - urinary bladder
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791480178&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measurement of the bioavailability of iron, using the rat hemoglobin repletion test.
AU - Fritz, J. C.
AU - Pla, C. W.
AU - Harrison, B. N.
AU - Clark, G. A.
AU - Smith, E. A.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 3
SP - 709
EP - 714
AD - Fritz, J. C.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19781474361. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Variations in the AOAC official first action method of Fritz et al. (NAR 45, 3941) were studied.
KW - haemoglobin
KW - iron
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hemoglobin
KW - repletion of haemoglobin for iron availability test
KW - Techniques and Methodology (ZZ900)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781474361&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas-liquid chromatographic determination of Kepone residues in finfish, shellfish, and crustaceans.
AU - Carver, R. A.
AU - Borsetti, A. P.
AU - Kamps, L. R.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 4
SP - 877
EP - 883
AD - Carver, R. A.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19791476992. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
KW - fish
KW - pesticides
KW - shellfish
KW - crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - estimation of pesticides in fish, shellfish and crustaceans
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791476992&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thin layer chromatographic method for the detection of uric acid: collaborative study.
AU - Thrasher, J. J.
AU - Abadie, A.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 4
SP - 903
EP - 905
AD - Thrasher, J. J.: Food and Drug Administration, Division of Microbiology, Washington, DC 20204, USA.
N1 - Accession Number: 19781476995. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 69-93-2. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The sample is dissolved in Li2CO3, chromatographed with butanol, methanol and 5 N acetic acid (1:1:1) and uric acid was detected by spraying with Na3PO4 and phosphotungstic acid and heating. The method was developed to detect bird and insect excreta in food.
KW - estimation
KW - separation
KW - uric acid
KW - separating
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781476995&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas-liquid chromatographic determination of volatile organic acids as benzyl esters with applications to tuna, shrimp, and eggs.
AU - Staruszkiewicz, W. F., Jr.
AU - Fernandez-Flores, E.
AU - Bond, J. F.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 4
SP - 973
EP - 981
AD - Staruszkiewicz, W. F., Jr.: Food and Drug Administration, Division of Food Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19781477000. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - Treatment with BCl3 and benzyl alcohol gave benzyl esters which were estimated by gas chromatography. The method was used to estimate in foods propionic, isobutyric, butyric and, particularly, acetic and formic acids, which are useful indicators of decomposition.
KW - eggs
KW - fish
KW - organic acids
KW - saturated fatty acids
KW - crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - estimation of volatile organic acids in tuna, shrimps and eggs
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781477000&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Associations of cancer mortality with halomethanes in drinking water.
AU - Blot, W. J.
AU - Fraument, J. F., Jr.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1978///
VL - 61
IS - 4
SP - 979
EP - 985
SN - 0027-8874
AD - Blot, W. J.: Environmental Epidemiology Branch, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health, Education and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19791483178. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - Associations between site- and sex-specific county cancer mortality rates and amounts of trihalomethanes (THM) in drinking water were examined after adjustment of rates for the influence of multiple socioeconomic, industrial and demographic factors. US counties with sampled supplies were grouped by percentage of the county population receiving water from the supply and by region of the country. For 2 sites (bladder and lung), county rates were also adjusted for the activity level in specific high-risk industries. Correlations with THM values were positive for several cancers, including bladder and brain cancers in both sexes, and non-Hodgkin's lymphoma and kidney cancer in men. Stomach cancer in women showed a negative association. Bladder cancer mortality rates showed the strongest and most consistent association with a THM exposure index, after control for differences in social class, ethnic group, urban against rural residence, region of the USA and industrialization of the county.
KW - contaminants
KW - drinking water
KW - neoplasms
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - halomethanes in drinking water and cancer mortality
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791483178&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Geographic patterns of bladder cancer in the United States.
AU - Blot, W. J.
AU - Fraumeni, J. F., Jr.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1978///
VL - 61
IS - 4
SP - 1017
EP - 1023
SN - 0027-8874
AD - Blot, W. J.: Environmental Epidemiology Branch, National Cancer Inst., National Inst. Health, Public Health Service, US Dep. Health Education and Welfare, Bethesda, MD. 20014, USA.
N1 - Accession Number: 19791483179. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition
N2 - Age-adjusted rates of mortality during 1950-69 from bladder cancer were correlated with demographic and industrial indexes for the 3056 counties of the contiguous states of the USA. Rates among whites and nonwhites of both sexes rose sharply with urbanization. A small but positive socioeconomic gradient was observed; mortality was slightly higher among men in counties with high percentages of British and German residents. Even after controlling for demographic variables, the Northeastern excess of bladder cancer among whites was sizable, whereas the regional differences among nonwhites were small. The high rates in the Northeast were seen in both sexes and in rural and urban areas, with mortality in small counties in upstate New York and New England equalling or exceeding those in large metropolitan centres elsewhere in the country. Outside the Northeast, high rates were generally limited to urban areas, but clusters of high mortality occurred among white men along the Illinois-Wisconsin border, in parts of lower Michigan and in southern Louisiana. Industrial factors may explain at least part of the geographical clustering, inasmuch as rates among men were significantly higher in US counties where the chemical industry is heavily concentrated. Increases were also associated with the printing industry, but correlations with 16 other major manufacturing industries were near or below expected levels.
KW - BLADDER
KW - neoplasms
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bladder cancer incidence in USA
KW - cancers
KW - United States of America
KW - urinary bladder
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791483179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of cured meat products for volatile N-nitrosamines: comparison of two analytical methods.
AU - Havery, D. C.
AU - Fazio, T.
AU - Howard, J. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 6
SP - 1374
EP - 1378
AD - Havery, D. C.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19791481177. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - In a study of 106 samples of cured meat N-nitrosopyrrolidine was found, 5 to 75 ng/g in fried bacon, and unconfirmed trace amounts of N-nitrosodimethylamine in a variety of products. Gas-liquid chromatography-mass spectrometry and a thermal energy analyser gave similar results.
KW - bacon
KW - meat products
KW - nitrosamines
KW - estimation of nitrosamines in cured meat products
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791481177&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in levels of N-nitrosopyrrolidine in fried bacon.
AU - Havery, D. C.
AU - Fazio, T.
AU - Howard, J. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1978///
VL - 61
IS - 6
SP - 1379
EP - 1382
AD - Havery, D. C.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19791481178. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 930-55-2. Subject Subsets: Human Nutrition
N2 - The content of N-nitrosopyrrolidine in 9 brands of fried bacon has generally decreased since 1971. This is partly explained by decreasing use of nitrite and increasing use of ascorbate in curing mixtures. Most recent mean values ranged from 5 to 75, average 18 ng/g. Raw bacon did not contain nitrosamines.
KW - bacon
KW - nitrosopyrrolidine
KW - nitrosopyrrolidine in fried bacon
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791481178&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunologic studies on hamsters infected with Entamoeba histolytica.
AU - Gold, D.
AU - Norman, L. G.
AU - Maddison, S. E.
AU - Kagan, I. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1978///
VL - 64
IS - 5
SP - 866
EP - 873
SN - 0022-3395
AD - Gold, D.: Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19790854314. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - The serologic and cell-mediated immune responses of hamsters exposed to 2 strains of Entamoeba histolytica (HM-1 and HM-19) were evaluated by a series of in vitro tests. The pathogenicity of the 2 strains were evaluated by the indirect haemagglutination test. The cellular immune response was assayed by increased DNA synthesis by lymphocytes and migration inhibition of macrophages. [AS]
KW - immunology
KW - parasites
KW - Entamoeba histolytica
KW - hamsters
KW - protozoa
KW - Rodents
KW - Entamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790854314&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Study of coinciding foci of malaria and leptospirosis in the Peruvian Amazon area.
AU - Sulzer, A. J.
AU - Sulzer, K. R.
AU - Cantella, R. A.
AU - Colichon, H.
AU - Latorre, C. R.
AU - Welch, M.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1978///
VL - 72
IS - 1
SP - 76
EP - 83
SN - 0035-9203
AD - Sulzer, A. J.: Parasit. Div., Center for Disease Control, Public Health Service, US Dep. of Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19780844208. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - A hyperendemic malaria focus, found in 1973 in a secluded valley in South-eastern Peru, was restudied in 1975. Tests for antibodies to Plasmodium and Leptospira were performed on blood serum and blood slides were collected at three locations on the Rio Ene and confluent streams and at two locations in the neighbouring highlands. The hyperendemic focus of P. vivax-P. malariae found at Mission Cutivirini in 1973 was confirmed in this study. Another hyperendemic focus of predominantly P. vivax was found at the village of Saoreni. Lesser amounts of malaria were found at other locations. Serology indicated past or present contact with Leptospira of from 50 to 75% of individuals at all locations. The two hyperendemic malaria foci therefore were embedded in a much larger hyperendemic focus of leptospirosis. The value of the indirect immunofluorescence test for malarial antibodies as a sero-epidemiological tool was emphasized by this study. [AS]
KW - diagnosis
KW - parasites
KW - surveys
KW - Peru
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Andean Group
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Haemosporida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780844208&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional status of lacto-ovo vegetarian Trappist monks.
AU - Harland, B. F.
AU - Peterson, M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1978///
VL - 72
IS - 3
SP - 259
EP - 264
SN - 0002-8223
AD - Harland, B. F.: Division of Nutrition, Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19781468619. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - For 16 lacto-ovo vegetarians in a Trappist monastery, dietary intake of 22 nutrients was estimated with 4-week menus and a 24-h dietary recall. Blood and urine were sampled; serum Hg and Zn were estimated by atomic absorption spectrometry; 14 other constituents were measured. Serum glucose and cholesterol and bodyweight were normal, but values for Ca, Fe, Mg, Zn and the B vitamins were low.
KW - nutritional state
KW - vegetarians
KW - nutritional state of lacto-ovo vegetarians
KW - nutritional status
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781468619&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of standards on the nutritional care of the elderly.
AU - Smith, C. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1978///
VL - 73
IS - 2
SP - 115
EP - 119
SN - 0002-8223
AD - Smith, C. E.: Public Health Service, Dep. Health, Education and Welfare, Rockville, Md., USA.
N1 - Accession Number: 19781476861. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - An historical perspective on the influence which state and federal standards have had, directly and indirectly, on nutritional care of the elderly in nursing homes in the USA.
KW - nutrition
KW - old age
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional standards and care of old people in USA
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781476861&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Essential fatty acid deficiency in total parenteral nutrition: time course of development and suggestions for therapy.
AU - Goodgame, J. T.
AU - Lowry, S. F.
AU - Brennan, M. F.
JO - Surgery, USA
JF - Surgery, USA
Y1 - 1978///
VL - 84
IS - 2
SP - 271
EP - 277
AD - Goodgame, J. T.: Dep. Health, Education and Welfare, Public Health Service, National Inst. Health, Bethesda, MD 20014, USA.
N1 - Accession Number: 19781477949. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - Thirty-two patients receiving total intravenous nutrition were studied prospectively for biochemical and clinical signs of essential fatty acid deficiency. Individual constituents of the phospholipid fraction were examined consecutively and the triene:tetraene ratio was estimated. All patients fed parenterally for 4 weeks had triene:tetraene ratios of more than 0.4. Plasma eicosatrienoic and linoleic acid values were abnormal after 1 week, and arachidonic acid became abnormal after 2 weeks of fat-free parenteral nutrition. Skin lesions suggestive of essential fatty acid deficiency developed in 2 patients studied. Biochemical abnormalities responded rapidly to intravenous Intralipid.
KW - fat
KW - lipids
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - correction of fat deficiency in total parenteral nutrition by intravenous lipid emulsion
KW - lipins
KW - parenteral nutrition
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781477949&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Amebiasis: epidemiologic studies in the United States, 1971-1974.
AU - Krogstad, D. J.
AU - Spencer, H. C., Jr.
AU - Healey, G. R.
AU - Gleason, N. N.
AU - Sexton, D. J.
AU - Herron, C. A.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1978///
VL - 88
IS - 1
SP - 89
EP - 97
SN - 0003-4819
AD - Krogstad, D. J.: Parasitic Diseases Branch, Cent. for Disease Control, Public Health Service, US Dep. of Health Education and Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19780845431. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Between October 1971 and June 1974, 7 investigations of suspected foci of amoebiasis lead to 3 conclusions. (i) A number of laboratories have vastly overdiagnosed amoebiasis and have reported leucocytes in stools as Entamoeba histolytica. 2 laboratories found to be in error were in community hospitals, and one was at a teaching hospital associated with a medical school and a school of public health. These 3 laboratories had been diagnosing more than 1,200 cases of amoebiasis a year for 20 years. (ii) When amoebiasis does occur, it is likely to be misdiagnosed. In one outbreak with 4 cases and 3 deaths, amoebiasis was not diagnosed until 2 patients had died and another was critically ill. Sporadic cases may be mistakenly diagnosed as ulcerative colitis and inappropriately treated with steroids. (iii) Foci of endemic amoebiasis continue to exist in the USA, both in institutions and non-institutional settings. [AS]
KW - diagnosis
KW - epidemiology
KW - parasites
KW - USA
KW - Entamoeba histolytica
KW - man
KW - protozoa
KW - Entamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - incidence & misdiagnosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19780845431&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of school water fluoridation on dental caries: results in Seagrove, NC, after eight years.
AU - Heifetz, S. B.
AU - Horowitz, H. S.
AU - Driscoll, W. S.
JO - Journal of the American Dental Association
JF - Journal of the American Dental Association
Y1 - 1978///
VL - 98
IS - 2
SP - 193
EP - 196
SN - 0002-8177
AD - Heifetz, S. B.: Caries Prevention and Research Branch, National Insts. Health, Public Health Service, US Dep. Health, Education and Welfare, Westwood Bldg., Bethesda, Md. 20014, USA.
N1 - Accession Number: 19801413302. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - In 1968 at Seagrove, NC, fluoride was added to the water supply of a rural school at 6.3 mg/litre, 7 times the optimum recommended for community water fluoridation in the area. Findings after 8 years showed that children in grades 1 to 9 had about 40% fewer DMF surfaces than their counterparts on the baseline. A comparison of these findings with those of another school fluoridation study, in which 4.5 times the optimum concentration had been tested, showed only a slight advantage to the children at Seagrove. However, the full potential of school water fluoridation at 7 times the optimum cannot be determined until children in all grades have been exposed since entering the first grade.
KW - children
KW - dental caries
KW - drinking water
KW - fluoridation
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - caries
KW - school water fluoridation on dental caries in North Carolina
KW - teeth caries
KW - tooth decay
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801413302&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Retention of dietary cadmium and the ameliorative effect of zinc, copper, and manganese in Japanese quail.
AU - Jacobs, R. M.
AU - Jones, A. O. L.
AU - Fox, M. R. S.
AU - Fry, B. E., Jr.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1978///
VL - 108
IS - 1
SP - 22
EP - 32
SN - 0022-3166
AD - Jacobs, R. M.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781468313. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7440-43-9, 7440-50-8, 7439-96-5, 7440-66-6. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - From hatching to 7 days old, male and female Japanese quail (Coturnix coturnix japonica) were fed on a purified soya bean basal diet (BD) containing (mg/kg) Zn 30, Cu 5 and Mn 12. From 7 to 14 days old, the birds ate 109Cd with either the BD alone or with minerals added (MSD) to double the amounts of Zn, Cu and Mn. Cd was given as cadmium chloride 62, 125, 250, 500 or 1000 mu g/kg diet; the control group had no Cd. The graded amounts of Cd caused a linear, log-dose, log-response accumulation of Cd in the duodenum, liver and kidneys. In comparison with the duodenum, the proportion of Cd retained by the liver and kidney was small. The proportion of 109Cd retained was independent of the amount of Cd given with diet. Birds given the MSD retained less 109Cd in the liver, kidneys and whole body than birds fed on BD alone. The Cd content of the duodenum was not affected by the mineral supplementation of the basal diet. The relative accumulation of Cd with MSD was 75 and 64%, respectively, of that with the BD alone in the liver and kidney. The section of the digestive tract distal to the duodenum retained less 109Cd when the birds were fed on the MSD than when given the BD alone. The findings suggest that the Cd concentration in the lower small intestine may be useful for the estimation of Cd in human foods and demonstrate the beneficial role of moderate excesses of essential elements in decreasing absorption and retention of low dietary Cd.
KW - cadmium
KW - copper
KW - manganese
KW - poultry
KW - supplements
KW - zinc
KW - Japanese quails
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cadmium retention
KW - domesticated birds
KW - manganese supplement
KW - Mn
KW - role of essential elements in reducing cadmium absorption and retention (Japanese quail)
KW - Animal Nutrition (Physiology) (LL510)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Production Responses) (LL520)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19781468313&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - K+ deprivation potentiates the renal alkalosis-producing effect of mineralocorticoid.
AU - Hulter, H. N.
AU - Sigala, J. F.
AU - Sebastian, A.
JO - American Journal of Physiology
JF - American Journal of Physiology
Y1 - 1978///
VL - 235
IS - 4
SP - F298
EP - F309
SN - 0002-9513
AD - Hulter, H. N.: Renal Lab., Public Health Service Hospital, San Francisco 94118, USA.
N1 - Accession Number: 19791480443. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 7440-09-7. Subject Subsets: Human Nutrition
N2 - When 30 female dogs weighing 15 to 20 kg which had been given a diet normal or deficient in potassium were given 7.5 mg deoxycorticosterone (DOC) by muscle twice daily for 5 days there was a greater cumulative increase in net acid excretion (NAE) and plasma bicarbonate concentration in the deprived group. Greatest difference in NAE between groups was on day 1 as the result of greater excretion of titratable acid and NH4+. The excretory response of NH4+ seemed to result in part from increased renal production of ammonia. The low-K diet also seemed to increase the stimulatory effect of DOC on H+ excretion independent of increased production of ammonia, by the kidneys. After DOC there was a greater decrease in pH in the deprived dogs. The absolute value of urine pH after DOC was not greater in the deprived group despite a greater amount of buffer in urine. The exaggerated NAE response was not associated with an exaggerated Na+ reabsorptive response or an attenuated K+ excretory response. The Cl- readsorptive response was attenuated and this may contribute to the increased effect of DOC in decreasing pH in the deprived group by limiting Cl- shunting of the mineralocorticoid-dependent luminal negativity.
KW - alkalosis
KW - kidneys
KW - mineralocorticoids
KW - potassium
KW - dogs
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - modification of renal alkalosis producing effect of mineralocorticoids by potassium deprivation
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791480443&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Chemotherapy for intestinal nematode infections of man.
AU - Aguilar, F. J.
T2 - 4th International Congress of Parasitology 19-26 August, 1978, Warsaw. Short communications, Section D.
JO - 4th International Congress of Parasitology 19-26 August, 1978, Warsaw. Short communications, Section D.
JF - 4th International Congress of Parasitology 19-26 August, 1978, Warsaw. Short communications, Section D.
Y1 - 1978///
SP - 46
EP - 47
CY - Warsaw; Poland
PB - Organizing Committee.
AD - Aguilar, F. J.: Central Lab., Public Health Service, Guatemala.
N1 - Accession Number: 19780852678. Publication Type: Conference paper. Language: English. Subject Subsets: Helminthology
KW - anthelmintics
KW - control
KW - DRUG THERAPY
KW - helminths
KW - parasites
KW - man
KW - Nematoda
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - chemotherapy
KW - nematodes
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulatory aspects of animal feeds in the United States.
AU - Bixler, W. B.
T2 - 3rd world congress of animal feeding. 1. Plenary sessions. 2. Round tables. 23rd-27th October 1978, Madrid, Spain; 3eme congres mondial d'alimentation animale; III. Tierernahrungs Weltkongress; III congreso mundial de alimentacion animal.
JO - 3rd world congress of animal feeding. 1. Plenary sessions. 2. Round tables. 23rd-27th October 1978, Madrid, Spain; 3eme congres mondial d'alimentation animale; III. Tierernahrungs Weltkongress; III congreso mundial de alimentacion animal.
JF - 3rd world congress of animal feeding. 1. Plenary sessions. 2. Round tables. 23rd-27th October 1978, Madrid, Spain; 3eme congres mondial d'alimentation animale; III. Tierernahrungs Weltkongress; III congreso mundial de alimentacion animal.
Y1 - 1978///
SP - 69
EP - 74
CY - Madrid; Spain
PB - International Veterinary Association for Animal Production.
SN - 8473910222
AD - Bixler, W. B.: Division of Animal Feeds, Bureau of Veterinary Medicine, US Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA.
N1 - Accession Number: 19791857037. Publication Type: Conference paper. Language: English. Language of Summary: Spanish. Subject Subsets: World Agriculture, Economics & Rural Sociology; Animal Nutrition
N2 - The US Food and Drug Administration, through its Bureau of Veterinary Medicine, regulates the interstate marketing of animal drugs, devices, and feeds with the goal of ensuring that only safe and effective products are marketed, based on an evaluation of scientific data provided by the sponsoring firms. In addition, it participates in surveillance and compliance programmes of product production, distribution, and use in US agriculture through a network of FDA field offices and in co-operation with individual States. FDA inspects feed mills to ensure that medicated feeds are manufactured under good practices and that various food contaminants do not endanger the food supply. In addition, FDA co-operates with other US Government agencies in the monitoring of drugs, pesticides, and other chemical residues, or contaminants in slaughtered livestock and poultry and also in milk and eggs. FDA regulates over 500 animal drug manufacturers and over 13,000 medicated feed mixing facilities. An estimated 110 million tons of animal feed (excluding hay and water) are manufactured annually, and approximately 80% of the meat and eggs consumed by the public has been derived from animals fed medicated feed at some time in their lifetime.
KW - feeds
KW - regulations
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - rules
KW - United States of America
KW - World Congress on Animal Feeding
KW - Marketing and Distribution (EE700)
KW - Laws and Regulations (DD500)
KW - Food Science and Food Products (Human) (QQ000)
KW - Forage and Feed Products (Non-human) (RR000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Indices for assessing cadmium bioavailability from human foods.
AU - Fox, M. R. S.
AU - Jacobs, R. M.
AU - Jones, A. O. L.
AU - Fry, B. E., Jr.
AU - Hamilton, R. P.
T2 - Trace element metabolism in man and animals - 3.
JO - Trace element metabolism in man and animals - 3.
JF - Trace element metabolism in man and animals - 3.
Y1 - 1978///
SP - 327
EP - 331
CY - Freising-Weihenstephan; German Federal Republic
PB - Arbeitskreis fur Tierernahrungsforschung Weihenstephan.
AD - Fox, M. R. S.: Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19781471070. Publication Type: Miscellaneous. Language: English. Number of References: 3 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
N2 - Uptake of Cd by jejunoileal tissue of young Japanese quail after 7-day feeding tests gave concentrations that could be measured by flame atomic absorption spectrophotometry. Rates of Cd intake were mostly of the same order as in man. Availability of Cd from molluscs, liver and spinach ranged from 32 to 62% of that of Cd supplied as CdCl2.
KW - cadmium
KW - foods
KW - bioavailability from foods (Japanese quail)
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Trichinellosis in humans in the United States: epidemiologic trends.
AU - Juranek, D. D.
AU - Schultz, M. G.
A2 - : Kim, C.W. Pawlowski, Z.S.
T2 - Trichinellosis. Proceedings of the 4th International Conference on trichinellosis, 27-28 August, 1976, Poznan, Poland.
JO - Trichinellosis. Proceedings of the 4th International Conference on trichinellosis, 27-28 August, 1976, Poznan, Poland.
JF - Trichinellosis. Proceedings of the 4th International Conference on trichinellosis, 27-28 August, 1976, Poznan, Poland.
Y1 - 1978///
SP - 523
EP - 528
CY - Hanover, New Hampshire; USA
PB - University Press of New England.
AD - Juranek, D. D.: Parasitic Diseases Branch, Parasit. Dis. & Vet. Public Health Div., Bureau of Epidem., Center for Disease Control, US Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19790862659. Publication Type: Conference paper. Language: English. Subject Subsets: Helminthology
N2 - Epidemiological data on human trichinelliasis from 1967 to 1976 in the USA are summarized from the work done by the Centre for Disease Control in Georgia. Trichinelliasis is no longer a public health menace, even though the numbers reported have steadily increased since 1972. The fatalities, however, remain low (in 1947, 14 deaths occurred but only 10 deaths occurred from 1967 to 1975). Analysis of the data on 1212 cases of trichinelliasis revealed no seasonal patterns in the occurrence of cases or outbreaks, the mean age of 1119 patients was 33.7 years and there were no sex differences. Pork products were found to be responsible for 75% of cases; 13% originated from other meats and 12% from undetermined sources. 11 major outbreaks involving 10 to 92 persons were reported during these 9 years. In 1975, 28 of 45 people became infected after eating walrus meat ("raw" or "fresh"), which is believed to be the first reported common-source outbreak caused by this host in North America. The control measures required are briefly discussed.
KW - epidemiology
KW - helminths
KW - parasites
KW - USA
KW - Enoplida
KW - man
KW - Trichinella spiralis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Trichinella
KW - Trichinellidae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Nematoda
KW - invertebrates
KW - Enoplia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Adenophorea
KW - nematodes
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Teratogenicity of heavy metals.
AU - Earl, F. L.
AU - Vish, T. J.
A2 - Oehme, F.W.
T2 - Toxicity of heavy metals in the environment
JO - Toxicity of heavy metals in the environment
JF - Toxicity of heavy metals in the environment
Y1 - 1978///
SP - 617
EP - 639
CY - New York, N.Y.; USA
PB - Marcel Dekker, Inc.
AD - Earl, F. L.: Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19791492075. Publication Type: Miscellaneous. Language: English. Number of References: 134 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science
KW - adverse effects
KW - heavy metals
KW - metals
KW - Reviews
KW - teratogenesis
KW - teratogens
KW - toxicity
KW - Toxicology
KW - adverse reactions
KW - heavy metals and teratogenicity
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dengue in 1977-1978.
AU - Woodall, J. P.
AU - Lopez-Correa, R. H.
AU - Cabrera, F.
AU - Levy-Koenig, E.
AU - Pamphile, M.
AU - Sather, G. E.
JO - Newsletter on Dengue, Yellow Fever, and Aedes aegypti in the Americas
JF - Newsletter on Dengue, Yellow Fever, and Aedes aegypti in the Americas
Y1 - 1979///
VL - 8
IS - 1
SP - 5
EP - 8
AD - Woodall, J. P.: San Juan Laboratories, Bureau of Laboratories, US Public Health Service, San Juan, Puerto Rico, USA.
N1 - Accession Number: 19800569623. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Before 1977, no dengue epidemics had been reported on Hispaniola (comprising the Dominican Republic and Haiti) during any of the 9 Caribbean pandemics occurring over the preceding 150 years. In 1977, however, dengue was reinstated as a reportable disease in Haiti and various evidence indicated the occurrence of a minor epidemic of type-1 dengue with 433 cases there in November. Evidence of only endemic infection was found in the Dominican Republic. The reasons why Hispaniola has escaped the pandemics when dengue is clearly endemic on the island is briefly discussed. A programme to control Aedes aegypti (L.) in the city of Santo Domingo, Dominican Republic, may have contributed to protection in late 1977, but no such vector control measures were undertaken in Haiti, where the mosquito is abundant.
KW - control
KW - dengue
KW - mosquito nets
KW - vector control
KW - Dominican Republic
KW - Haiti
KW - Aedes aegypti
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Developing Countries
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - Threshold Countries
KW - Caribbean Community
KW - Least Developed Countries
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800569623&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recovery of Mermet virus from Culex mosquitoes (Diptera: Culicidae) collected in Memphis, Tennessee, USA.
AU - Jakob, W. L.
AU - Francy, D. B.
AU - Trimble, J. M.
AU - Calisher, C. H.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1979///
VL - 16
IS - 1
SP - 80
EP - 81
SN - 0022-2585
AD - Jakob, W. L.: Vector-borne Diseases Division, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19790567636. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - In 1977 a strain of Mermet virus (of the Simbu group) and which had previously been isolated only from birds) was isolated from a pool of Culex restuans Theo. and another from a pool of mosquitoes of the complex of C. pipiens L., both collected near Memphis, Tennessee. The virus recoveries from these mosquitoes, in conjunction with their frequent feeding on passerine birds (from which all other strains of Mermet virus have so far been isolated), suggest that one or both species may serve as natural vectors.
KW - groups
KW - mosquito nets
KW - Tennessee
KW - USA
KW - Culex
KW - Culex pipiens
KW - Culex restuans
KW - Culicidae
KW - Diptera
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - Mermet virus
KW - mosquitoes
KW - United States of America
KW - Other Control Measures (HH700)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - St. Louis encephalitis virus transmission following multiple feeding of Culex pipiens pipiens (Diptera: Culicidae) during a single gonotrophic cycle.
AU - Mitchell, C. J.
AU - Bowen, G. S.
AU - Monath, T. P.
AU - Cropp, C. B.
AU - Kerschner, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1979///
VL - 16
IS - 3
SP - 254
EP - 258
SN - 0022-2585
AD - Mitchell, C. J.: Center for Disease Control, Public Health Service, USDHEW, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19800569655. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Under experimental conditions, 3 of 31 females of Culex pipiens pipiens L. became infected with St. Louis encephalitis (SLE) virus after partial engorgement and without becoming gravid. In addition, SLE virus was transmitted by 2 females during a single gonotrophic cycle. It is concluded that multiple feeding during a single gonotrophic cycle could increase the chances of mosquitoes acquiring and transmitting the virus; also, if an infective partial blood-meal taken in late summer or autumn were followed by successful overwintering, winter carry-over of virus could be accomplished by nulliparous mosquitoes.
KW - disease transmission
KW - mosquito nets
KW - transmission
KW - Culex pipiens
KW - Culex pipiens pipiens
KW - Culicidae
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - viruses
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex pipiens
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800569655&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Winter survival of Culex tarsalis (Diptera: Culicidae) hibernating in mine tunnels in Boulder County, Colorado, USA.
AU - Mitchell, C. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1979///
VL - 16
IS - 6
SP - 482
EP - 487
SN - 0022-2585
AD - Mitchell, C. J.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19800572159. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The mark-release-recapture technique was applied for the first time to the study of winter survival in Culex tarsalis Coq.; 377 hibernating females were collected in October 1977 from an abandoned gold-mine tunnel near Jamestown, Colorado, marked with zinc sulfide dust and released into the mine. Recovery of 8.7% of the marked population 3-5 months later provided only a crude estimate of survival rates. A total of 1088 females was collected from the same and other nearby mines from September 1977 to March 1978. Among 606 collected, 2.8% were parous, 89.9% nulliparous and 7.3% undetermined. In 905 examples tested for arboviruses after being kept in the laboratory for 2 weeks at 26.7 deg C and 16 h light daily, and fed on chicks, no virus was isolated from either the mosquitoes or the chicks.
KW - mosquito nets
KW - overwintering
KW - survival
KW - Colorado
KW - USA
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - gold mines
KW - mine tunnels
KW - mosquitoes
KW - United States of America
KW - Other Control Measures (HH700)
KW - Animal Behaviour (LL300)
KW - Economics (General) (EE100) (Discontinued June 2002)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenicity studies of R-amino salt, a metabolite of amaranth (FD & C Red No. 2), in mouse lymphoma cells heterozygous at the thymidine kinase locus and in the rat dominant lethal test.
AU - Palmer, K. A.
AU - Sheu, C. W.
AU - Green, S.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1979///
VL - 17
IS - 1
SP - 5
EP - 9
AD - Palmer, K. A.: Genetic Toxicology Branch, Division of Toxicology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19791485202. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 915-67-3. Subject Subsets: Human Nutrition
N2 - The R-amino salt (1-amino-2-naphthol-3,6-disulphonic acid sodium salt) of the red food colouring amaranth (FD & C Red No. 2) when tested for mutagenicity in the thymidine kinase heterozygous mouse test showed a dose-related increase in mutation frequency compared with control values. Giant cells were present in cultures after treatment and there was a colour change when the R-amino salt was dissolved in the tissue-culture medium. The effect of the R-amino salt was not significant in the dominant lethal test.
KW - amaranth dye
KW - dyes
KW - food additives
KW - mutagens
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dyestuffs
KW - mutagenicity of R-amino salt in amaranth dye
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of calcium and sodium carrageenans and iota -carrageenan on hamster foetal development.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Prew, J. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1979///
VL - 17
IS - 5
SP - 443
EP - 449
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, DC 20204, USA.
N1 - Accession Number: 19791496936. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 9000-07-1. Subject Subsets: Human Nutrition
N2 - On days 6 to 10 of pregnancy Syrian hamsters were given calcium kappa , lambda -carrageenan, sodium kappa , lambda -carrageenan or iota -carrageenan C-16 10, 40, 100 or 200 mg/kg bodyweight by tube. None of the compounds had a dose-related teratogenic or toxic effect on the foetuses.
KW - carrageenan
KW - FETUS
KW - food additives
KW - teratogenesis
KW - foetal toxicity of carrageenan (hamster)
KW - foetus
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791496936&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of interlaboratory results for blood lead with results from a definitive method.
AU - Boone, J.
AU - Hearn, T.
AU - Lewis, S.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1979///
VL - 25
IS - 3
SP - 389
EP - 393
SN - 0009-9147
AD - Boone, J.: Licensure and Proficiency Testing Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Dep. HEW, Atlanta. GA 30333, USA.
N1 - Accession Number: 19791484164. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Lead was estimated in blood by 113 participants using anodic stripping voltametry or atomic absorption spectroscopy. Compared with a definitive method using mass spectroscopy-isotopic dilution values tended to be too big with an actual content below 400 mu g/litre and too small with a content above 500 mu g/litre.
KW - blood
KW - estimation
KW - lead
KW - volume determination
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Separation of protoporphyrins and related compounds by reversed-phase liquid chromatography.
AU - Culbreth, P.
AU - Walter, G.
AU - Carter, R.
AU - Burtis, C.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1979///
VL - 25
IS - 4
SP - 605
EP - 610
SN - 0009-9147
AD - Culbreth, P.: Bureau of Laboratories, Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19791486215. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
KW - porphyrins
KW - separation of protoporphyrins
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791486215&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemical inhibition used in a kinetic urease/glutamate dehydrogenase method for urea in serum.
AU - Sampson, E. J.
AU - Baird, M. A.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1979///
VL - 25
IS - 10
SP - 1721
EP - 1729
SN - 0009-9147
AD - Sampson, E. J.: Clinical Chemistry Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Dep. HEW, Atlanta, GA 30333, USA.
N1 - Accession Number: 19791494472. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 57-13-6. Subject Subsets: Human Nutrition
KW - estimation
KW - serum
KW - urea
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791494472&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relationships of Bunyamwera group viruses by neutralization.
AU - Hunt, A. R.
AU - Calisher, C. H.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1979///
VL - 28
IS - 4
SP - 740
EP - 749
SN - 0002-9637
AD - Hunt, A. R.: Arbovirus Reference Branch, Public Health Service, US Department of Health, Education, and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19790565711. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2 - A standardised serum dilution plaque reduction neutralisation test was used for cross-neutralisation studies of 23 strains of Bunyamwera serogroup viruses. Antigenic relationships were determined by inspection of the neutralisation tests results as well as by numerical taxonomic analysis. Based on these analyses, 5 complexes, each containing 1-11 viruses, were distinguished. Little or no cross-reactivity was observed between viruses of different complexes. Three of the viruses tested were indistinguishable from prototypes and probably represent strains or varieties of those prototypes. A tentative classification scheme for the Bunyamwera group is presented.
KW - classification
KW - mosquito nets
KW - Neutralization tests
KW - Nomenclature
KW - Taxonomy
KW - Virology
KW - Bunyamwera virus
KW - Bunyaviridae
KW - Culicidae
KW - Diptera
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orthobunyavirus
KW - Bunyaviridae
KW - mosquitoes
KW - systematics
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790565711&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of nutritional factors on metabolism of dietary cadmium at levels similar to those of man.
AU - Fox, M. R. S.
AU - Jacobs, R. M.
AU - Jones, A. O. L.
AU - Fry, B. E., Jr.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 1979///
VL - 28
SP - 107
EP - 114
SN - 0091-6765
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, 200 C St., SW., Washington, DC 20204, USA.
N1 - Accession Number: 19801411448. Publication Type: Journal Article. Language: English. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
N2 - A diet based on casein and gelatin with zinc 12, 20 or 60 mg/kg was given to young Japanese quail with 109Cd (as the chloride) and added cadmium 0.062 mg/kg decreased the Cd concentrations in the proventriculus-ventriculus, duodenum, jejunum-ileum and the liver, but not in the kidney. Zn also affected Zn, iron, manganese and copper in some tissues. Different tissue concentration patterns of Cd and essential minerals were obtained with 2 purified control diets, one based on casein-gelatin and the other on soya bean isolate as the main sources of protein. The results showed that relatively small dietary changes can affect tissue Cd and that a low intake of Zn may increase the risk to dietary Cd exposure.
KW - cadmium
KW - diet affects cadmium metabolism (Japanese quail)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801411448&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safe levels of cadmium in intravenous diets.
AU - Fox, M. R. S.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1979///
VL - 32
IS - 4
SP - 725
EP - 727
SN - 0002-9165
AD - Fox, M. R. S.: Minerals Section, Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19791488501. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
KW - cadmium
KW - parenteral feeding
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - safe cadmium level in intravenous diets
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791488501&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phoretic relationship between bird Mallophaga and mosquitoes.
AU - Jakob, W. L.
AU - Eads, R. B.
JO - Mosquito News
JF - Mosquito News
Y1 - 1979///
VL - 39
IS - 1
SP - 137
EP - 137
AD - Jakob, W. L.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19790564462. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Three recoveries of bird Mallophaga from species of Culex are reported from investigations in 1974-78 in which more than 500 000 mosquitoes were examined. A species of Formicaphagus was found attached by its mouthparts to the proboscis of a female of C. nigripalpus Theo. collected in Ecuador in June 1974; a species of Formicaricola was recovered from a pool of C. vomerifer Komp from Ecuador in May 1978; and a species of Formicaphagus was found attached to the proboscis of a female of an unidentified species of Culex in Brazil in April 1976.
KW - mosquito nets
KW - Brazil
KW - Ecuador
KW - Culex
KW - Culex nigripalpus
KW - Culex vomerifer
KW - Culicidae
KW - Diptera
KW - Mallophaga
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Phthiraptera
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Andean Group
KW - Formicaphagus
KW - Formicaricola
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790564462&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selected pupal phenotypes of Anopheles freeborni and their susceptibility to Plasmodium falciparum and P. vivax.
AU - Collins, W. E.
AU - Warren, McW.
AU - Richardson, B. B.
AU - Skinner, J. C.
AU - Kearse, T. S.
JO - Mosquito News
JF - Mosquito News
Y1 - 1979///
VL - 39
IS - 3
SP - 466
EP - 472
AD - Collins, W. E.: Vector Biol. and Control Div., Bureau of Trop. Diseases Cent. for Disease Control, Public Health Service, U.S. Dep. of Health, Education, and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19800871493. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Naturally occurring and selected pupal colour phenotypes of Anopheles freeborni were found to vary in their susceptibility to two different strains of Plasmodium falciparum and one strain of P. vivax. With the Santa Lucia strain of P. falciparum from El Salvador, 4 naturally occurring pupal phenotypes were less susceptible to infection than the base colony. After selection, there were no differences between the different phenotypes and the base colony. Brown and green nonstriped forms were more susceptible than brown striped forms. When the selected lines were fed upon monkeys infected with the West African I strain of P. falciparum, all of the selected lines were more susceptible than the base colony. With the Salvador II strain of P. vivax, naturally occurring green nonstriped forms were less susceptible than brown striped and nonstriped forms. Upon selection, the advantage shifted to the green nonstriped and brown striped forms. A comparison with previous studies with A. albimanus indicated that the relationship between susceptibility to infection and pupal phenotype varied not only between the species of mosquito but between the 2 malaria parasites, P. vivax and P. falciparum. [AS]<new para>ADDITIONAL ABSTRACT:<new para>Naturally occurring and selected pupal-colour phenotypes of Anopheles freeborni Aitken were found to vary in their susceptibility to 2 different strains of Plasmodium falciparum and 1 strain of P. vivax. With the Santa Lucia strain of P. falciparum from El Salvador, 4 pupal phenotypes that occurred naturally in a base (laboratory) colony were less susceptible to infection than the base colony; after selection, there were no differences between the different phenotypes and the base colony. Brown and green non-striped forms were more susceptible than brown striped forms. When the selected lines were fed on monkeys infected with the West African I strain of P. falciparum, all of the selected lines were more susceptible than the base colony. With the Salvador II strain of P. vivax, naturally occurring green non-striped forms were less susceptible than brown striped and non-striped forms. A comparison with earlier studies on A. albimanus Wied. indicated that the relation between susceptibility to infection and pupal phenotype varied not only between species of mosquitoes but between the 2 malarial parasites P. vivax and P. falciparum.
KW - infectivity
KW - mosquito nets
KW - parasites
KW - strain differences
KW - El Salvador
KW - Anopheles freeborni
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - insects
KW - Plasmodium
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Haemosporida
KW - mosquitoes
KW - pupal phenotypes
KW - Salvador
KW - susceptibility of pupal phenotypes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800871493&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Naturally occurring pupal phenotypes of Anopheles albimanus and their susceptibility to Plasmodium vivax and P. falciparum.
AU - Warren, McW.
AU - Collins, W. E.
AU - Richardson, B. B.
AU - Skinner, J. C.
JO - Mosquito News
JF - Mosquito News
Y1 - 1979///
VL - 39
IS - 3
SP - 472
EP - 477
AD - Warren, McW.: Vector Biol. and Control Div., Bureau of Trop. Diseases, Cent. for Disease Control, Public Health Service, U.S. Dep. of Health, Education, and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19800871494. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology
N2 - The pupal phenotypes found to occur naturally in 3 different strains of Anopheles albimanus from El Salvador were tested for their susceptibility to coindigenous strains of Plasmodium vivax and P. falciparum. The Melara strain contained both brown striped and brown nonstriped forms, and a significant difference was seen between these 2 phenotypes only with the mean percent infected in the P. vivax experiments. The CA 109-A strain had brown and green forms which were homogeneous in their susceptibility to both P. vivax and P. falciparum. The Apastepeque strain contained brown striped as well as green and brown nonstriped forms. Significant differences in susceptibility to P. vivax were seen in comparisons between the base colony and each of the phenotypes as well as in comparisons between striped and nonstriped and the green phenotype. Variations in susceptibility between the base colony and 3 phenotypes were less apparent with P. falciparum in that significant differences were seen only in comparison between the base colony and green and between brown striped and green phenotypes. The importance of variable parasite susceptibility between and within strains of anophelines in the epidemiology of malaria is discussed. [AS]
KW - parasites
KW - El Salvador
KW - Anopheles albimanus
KW - Culicidae
KW - insects
KW - Plasmodium
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Plasmodium
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Haemosporida
KW - mosquitoes
KW - Salvador
KW - susceptibility of pupal phenotypes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800871494&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food safety and public health. Interaction of science and law in the federal regulatory process.
AU - Cordle, F.
AU - Kolbye, A. C.
JO - Cancer, USA
JF - Cancer, USA
Y1 - 1979///
VL - 43
IS - 5
SP - 2143
EP - 2150
AD - Cordle, F.: Epidemiology Unit (HFF-108), Bureau of Foods, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19811422886. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition
N2 - The programmes of the Food and Drug Administration (FDA), which operates under a broad mandate of regulatory authority provided by the US Congress in the form of the Food, Drug, and Cosmetic Act, demonstrate the way in which science and law interact to protect public health through the regulatory process. In particular, sections 402, 406 and 409 of the Act provide the means for regulating new and old food products approved for use by the petition process as well as foods which present a potential hazard because of environmental accidents which result in residues of undesirable or dangerous chemical substances. The episodes of foods contaminated with polychlorinated biphenyls or polybrominated biphenyls, and the manner in which action levels or guidelines were developed to regulate the allowable amounts of those chemicals in foods, describe the pragmatic way in which FDA protects public health by restricting the allowable amounts of chemical substances in foods.
KW - food legislation
KW - public health
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - public health protection by food legislation in USA
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811422886&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Zinc interference with copper, iron and manganese in young Japanese quail.
AU - Hamilton, R. P.
AU - Fox, M. R. S.
AU - Fry, B. E., Jr.
AU - Jones, A. O. L.
AU - Jacobs, R. M.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1979///
VL - 44
IS - 3
SP - 738
EP - 741
SN - 0022-1147
AD - Hamilton, R. P.: Division of Nutrition, Bureau of Foods, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19791488821. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 7440-50-8, 7439-89-6, 7439-96-5, 7440-66-6. Subject Subsets: Human Nutrition
N2 - From hatching to 14 days old Japanese quail (Coturnix coturnix japonica) were given diets with copper 1.0, 1.5 (the requirement value) or 3.6 mu g/g and supplementary zinc 15.6 to 2000 mu g/g. By 14 days antagonism of Zn to Cu, iron and manganese was evident. Supplementary Zn decreased growth and feather pigmentation and caused mild perosis and anaemia; the first 3 aspects were generally more severe when dietary Cu was marginally deficient. Zn accumulated in duodenum and liver in relation to the dietary content. Supplementary Zn decreased contents of Fe, Mn and Cu in liver. The adequacy of Cu in diet is important when the Zn intake is increased.
KW - copper
KW - iron
KW - manganese
KW - zinc
KW - Mn
KW - zinc affects iron, manganese and copper requirement (quail)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791488821&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sample homogenization procedure for determination of lead in canned foods.
AU - Jones, J. W.
AU - Boyer, K. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1979///
VL - 62
IS - 1
SP - 122
EP - 128
AD - Jones, J. W.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19791484459. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - The canned food with an equal weight of 10% HNO3 is left for 16 h and blended in a high-efficiency, probe-type Polytron homogenizer. Lead is estimated after dry- or wet-ashing.
KW - canned products
KW - canning
KW - composition
KW - estimation
KW - foods
KW - lead
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791484459&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of gel permeation chromatography and nonaqueous reverse phase chromatography to high pressure liquid chromatographic determination of retinyl palmitate and beta -carotene in oil and margarine.
AU - Landen, W. O., Jr.
AU - Eitenmiller, R. R.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1979///
VL - 62
IS - 2
SP - 283
EP - 289
AD - Landen, W. O., Jr.: Food and Drug Administration, 880 W Peachtree St., NW, Atlanta, GA 30309, USA.
N1 - Accession Number: 19791488732. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7235-40-7, 79-81-2. Subject Subsets: Human Nutrition
KW - beta-carotene
KW - margarine
KW - oils
KW - retinyl palmitate
KW - estimation of retinyl palmitate and beta-carotene in oil and margarine
KW - retinol palmitate
KW - vitamin A palmitate
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791488732&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spectrophotometric determination of caffeine in coffee products: collaborative study.
AU - Newton, J. M.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1979///
VL - 62
IS - 4
SP - 705
EP - 708
AD - Newton, J. M.: Food and Drug Administration, 50 United Nations Plaza, San Francisco, CA 94102, USA.
N1 - Accession Number: 19791491953. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 58-08-2. Subject Subsets: Human Nutrition
KW - caffeine
KW - coffee
KW - Coffea
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - estimation of caffeine in coffee products
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791491953&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lead, fluoride, and other elements in bonemeal supplements.
AU - Capar, S. G.
AU - Gould, J. H.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1979///
VL - 62
IS - 5
SP - 1054
EP - 1061
AD - Capar, S. G.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19791496643. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 16984-48-8, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Pb and Cd were estimated by differential pulse anodic stripping voltammetry, F by diffusion then specific electrode, and other elements by inductively-coupled argon plasma spectroscopy. Values for 20 commercial samples of bonemeal, 18 in tablet form, were Al 9.3 to 2040, Cr up to 26.4, Cu 1.1 to 14.1, F 261 to 921, Fe 15 to 1650, Mn up to 691, Ni up to 14.5, Pb 1.5 to 8.7, Ti up to 26.1 and Zn 63 to 14 000 mu g/g. One sample had Cd 2.5 and the others less than 0.05 mu g/g.
KW - bone meal
KW - fluoride
KW - lead
KW - minerals
KW - estimation and values of minerals in bone meal
KW - Other Produce (QQ070)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791496643&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Commonly used methods of analysis for tin in foods.
AU - Horwitz, W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1979///
VL - 62
IS - 6
SP - 1251
EP - 1264
AD - Horwitz, W.: Food and Drug Administration, Bureau of Foods, Washington, DC 20204, USA.
N1 - Accession Number: 19801401021. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 7440-31-5. Subject Subsets: Human Nutrition
KW - foods
KW - reviews
KW - tin
KW - review of estimation of tin content of foods
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801401021&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Retinoid-induced adhesion in cultured, transformed mouse fibroblasts.
AU - Adamo, S.
AU - Luca, L. M. De
AU - Akalovsky, I.
AU - Bhat, P. V.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1979///
VL - 62
IS - 6
SP - 1473
EP - 1477
SN - 0027-8874
AD - Adamo, S.: Lab. Experimental Pathology, Division of Cancer Cause and Prevention, National Cancer Inst., National Inst. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20014, USA.
N1 - Accession Number: 19791494846. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 302-79-4. Subject Subsets: Human Nutrition
N2 - Cultured, spontaneously transformed mouse fibroblasts (Balb/3T12-3 cells) were readily detached from the dish surface in an EDTA-mediated detachment test. Retinoic acid-treated cells showed increased adhesion to the culture dish surface. The effect of retinoic acid on the adhesion of Balb/3T12-3 cells was dose-dependent in the range of 0.05 to 5 mu g/ml (0.17 to 17 mu M) in an estimation on cells cultured for 3 days in the presence of the retinoid. The earliest effect on adhesion was detected at 2 days of culture in the presence of 17 mu M retinoic acid. The increase in adhesion shown by retinoic acid-treated cells was rapidly lost on removal of the retinoid from the culture medium. Synthetic retinoids were tested for their activity in inducing adhesion of cultured Balb/3T12-3 cells. Retinol, retinoic acid and their 5,6-epoxy derivatives were the most active, showing activity at 1 mu g/ml. 13-cis-Retinoic acid and the dimethylacetylcyclopentenyl and trimethylmethoxyphenyl derivatives were active at 10 mu g/ml. However, active derivatives of retinoic acid invariably lost their activity on chemical esterification or amide formation. Retinoids without biological activity in other systems were also inactive in inducing adhesion. Among these were the synthetic derivatives of retinol, anhydroretinol and perhydromonoeneretinol and the phenyl derivative of retinoic acid. beta -Ionone, abscisic acid, and juvenile hormone were also inactive. Results showed that this adhesion method may be used as an additional test for the biological activity of retinoids containing a free carboxylic or carbinolic function. The phenomenon of induced adhesion may also aid in the study of the metabolic function of vitamin A.
KW - fibroblasts
KW - retinoic acid
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adhesion to culture dish of retinoid-treated fibroblasts as index of biological activity of retinoids
KW - tretinoin
KW - vitamin A acid
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19791494846&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adoptive transfer of protective immunity in experimental schistosomiasis in the mouse.
AU - Maddison, S. E.
AU - Kagan, I. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1979///
VL - 65
IS - 4
SP - 515
EP - 519
SN - 0022-3395
AD - Maddison, S. E.: Center for Disease Control, Public Health Service, US Dep. of Health, Ed. & Welfare, Atlanta, GA. 30333, USA.
N1 - Accession Number: 19790866524. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - Passive transfer of immune serum alone did not confer protection to recipient mice irrespective of the routes of serum transfer or cercarial challenge of Schistosoma mansoni. Mice that received both sensitized cells and immune serum were protected against challenge by subcutaneous injection of cercariae but not by percutaneous exposure. The immune serum could be transferred as late as 8 days after subcutaneous challenge, suggesting that the protection was afforded in part by a late parasite killing mechanism which functions after the schistosomula have migrated through the lungs. [AS]
KW - helminths
KW - immunity
KW - immunology
KW - parasites
KW - MICE
KW - Rodents
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - parasitic worms
KW - Strigeida
KW - transfer of immunity
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790866524&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectivity of Plasmodium simium to Aotus trivirgatus monkeys and different anophelines.
AU - Collins, W. E.
AU - Warren, M.
AU - Contacos, P. G.
AU - Skinner, J. C.
AU - Richardson, B. B.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1979///
VL - 65
IS - 6
SP - 870
EP - 874
SN - 0022-3395
AD - Collins, W. E.: Vector Biol. & Control Div., Bureau of Trop. Dis., Center for Dis. Control, Public Health Service, US Dep. of Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19800872938. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Infections of Plasmodium simium were induced in splenectomized and intact Aotus trivirgatus griseimembra by parasitized blood and by sporozoites from Anopheles freeborni. 11 of 13 monkeys developed infection after sporozoite inoculation; prepatent periods ranged from 11 to 25 days (mean 15.8 days). Comparative infectivity studies indicated that A. freeborni were the most susceptible mosquitoes, followed by A. stephensi, A. balabacensis, A. maculatus, A. quadrimaculatus, A. culicifacies and A. albimanus. Studies with 3 pupal phenotypes of A. freeborni indicated that lines containing the green and non-striped pupal phenotypes were more susceptible than the base colony; the striped phenotype was slightly less susceptible than the base colony. [AS]
KW - infectivity
KW - mosquito nets
KW - parasites
KW - susceptibility
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles balabacensis
KW - Anopheles culicifacies
KW - Anopheles freeborni
KW - Anopheles maculatus
KW - Anopheles quadrimaculatus
KW - Anopheles stephensi
KW - Aotus trivirgatus
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - insects
KW - Plasmodium simium
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Aotus
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Aotus trivirgatus griseimembra
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800872938&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of free, total, and esterified cholesterol by high-performance liquid chromatography.
AU - Duncan, I. W.
AU - Culbreth, P. H.
AU - Burtis, C. A.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1979///
VL - 162
IS - 3
SP - 281
EP - 292
SN - 0021-9673
AD - Duncan, I. W.: Bureau of Labs., Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, Ga. 30333, USA.
N1 - Accession Number: 19791485070. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - Total cholesterol in saponified serum is extracted with hexane and estimated by liquid chromatography on mu Bondapak C18 with isopropanol and acetonitrile (1:1) as solvent. Free cholesterol is extracted with 5 volumes of isopropanol and chromatographed with isopropanol, acetonitrile and water (6:3:1).
KW - cholesterol
KW - cholesteryl esters
KW - estimation
KW - serum
KW - cholesterol esters
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Transmission of group C arboviruses (Bunyaviridae).
AU - Woodall, J. P.
A2 - Kurstak, E.
T2 - Arctic and tropical arboviruses.
JO - Arctic and tropical arboviruses.
JF - Arctic and tropical arboviruses.
Y1 - 1979///
SP - 123
EP - 138
CY - New York; USA
PB - Academic Press.
AD - Woodall, J. P.: San Juan Laboratories, US Public Health Service, GPO Box 4532, Puerto Rico 00936, Puerto Rico.
N1 - Accession Number: 19800572906. Publication Type: Miscellaneous. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The topics discussed in this review of the transmission by mosquitoes of group C arboviruses are the isolation of the 11 agents in the group from mosquitoes, wild vertebrates and man; evidence for mosquito transmission; vertebrate host preferences, vector susceptibility; vector abundance and age; competition for hosts; the arboreal niche; and their distribution (all occur in the Neotropical Region). Some previously unpublished information is included. It is concluded that the group C arboviruses (which are members of the Bunyaviridae) are maintained in nature by cycles involving small forest mammals (mainly rodents) and nocturnal mosquitoes (mainly species of Culex in the subgenus Melanoconion). Mechanisms exist that permit the coexistence of different members of the group of viruses in one locality.
KW - disease transmission
KW - transmission
KW - Bunyaviridae
KW - Culex
KW - Culicidae
KW - Diptera
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Melanoconion
KW - mosquitoes
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800572906&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Waterborne giardiasis. (Summary of recent epidemiologic investigations and assessment of methodology).
AU - Juranek, D.
A2 - : Jakubowski, W.
A2 - Hoff, J.C.
T2 - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
JO - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
JF - Waterborne transmission of giardiasis. (Proc. Symp. 18-20 Sept. 1978, Cincinnati, USA).
Y1 - 1979///
SP - 150
EP - 161
CY - Cincinnati, Ohio; USA
PB - US Environmental Protection Agency.
AD - Juranek, D.: Par. Dis. Div., Bureau of Epidem., Center for Dis. Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, Georgia, USA.
N1 - Accession Number: 19790863708. Publication Type: Miscellaneous. Language: English. Subject Subsets: Protozoology
N2 - From a review of the strengths and weaknesses of epidemiological investigations conducted in the USA in Rome, New York, 1975, Camas, Washington, 1976, and Berlin, New Hampshire, 1977 it is concluded that: 1) an alternative case identification technique to the one presently used is badly needed, but until a new technique becomes available the presently used criteria for defining a case should be standardized so that data obtained in one outbreak are comparable to those obtained in another; 2) greater care will be required in future investigations to insure that adequate specimens are collected to rule out bacterial and viral causes of diarrhoea; 3) the SPF dog model should continue to be used to demonstrate viability and infectivity of Giardia cysts recovered from water until an equally reliable laboratory method is identified and made available. The long-term solution to control of waterborne giardiasis lies in improvements in and widespread use of water filtration. However, there will continue to be a need for an effective and safe method for disinfecting water on an emergency basis in communities without water filtration and in those communities where established water filters have failed. [AS]
KW - control
KW - diagnosis
KW - epidemiology
KW - parasites
KW - USA
KW - Giardia duodenalis
KW - man
KW - protozoa
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Giardia lamblia
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19790863708&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Additional studies of male progeny of overwintering Culex pipiens complex mosquitoes from Memphis, Tennessee.
AU - Jakob, W. L.
AU - Taylor, S. A.
AU - Francy, D. B.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1980///
VL - 12
IS - 4
SP - 386
EP - 391
SN - 0091-3669
AD - Jakob, W. L.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810584231. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Overwintering females of the complex of Culex pipiens L. from Memphis, Tennessee were brought into the laboratory and allowed to oviposit. Their egg-rafts were reared separately, and the DV/D ratios [see RAE/B 40, p. 187] of the male offspring of 23 batches (each containing 47-215 individuals of both sexes, of which males formed about 53%) were determined; 2 methods of determination were compared, one being the more generally accepted interpretation of the DV/D ratio and the other a proposed stricter interpretation that would distinguish C. pipiens sens. strict. from other forms belonging to the complex, and the use of which markedly alters the dynamics of the study population. Further evidence is given that the forms of this complex should be regarded as infraspecific and that a self-sufficient intermediate population exists in the collection area.
KW - groups
KW - mosquito nets
KW - taxonomy
KW - Tennessee
KW - Culex
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - mosquitoes
KW - systematics
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584231&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antigenic relationships among Tacaiuma complex viruses of the Anopheles A serogroup (Bunyaviridae).
AU - Calisher, C. H.
AU - Lazuick, J. S.
AU - Muth, D. J.
AU - Lopes, O. de S.
AU - Crane, G. T.
AU - Elbel, R. E.
AU - Shope, R. E.
JO - Bulletin of the Pan American Health Organization
JF - Bulletin of the Pan American Health Organization
Y1 - 1980///
VL - 14
IS - 4
SP - 386
EP - 391
SN - 0085-4638
AD - Calisher, C. H.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, USDHEW, P.O.Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810584238. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - During unrelated field investigations on arboviruses in Arizona and Sao Paulo (Brazil), 2 viruses in the Anopheles A group (Bunyaviridae) were isolated. The Arizona isolate (743-366) was obtained from Anopheles freeborni Aitken and the name Virgin River virus is proposed for it. The Sao Paulo isolate (H-32580) was obtained from a woman; both viruses were found to be serologically related to the Tacaiuma complex. Evidence is presented that the Anopheles A group viruses are found principally in transmission cycles involving mammal-feeding mosquitoes throughout northern South America and in enzootic foci in Central and North America.
KW - mosquito nets
KW - Arizona
KW - USA
KW - Anopheles freeborni
KW - Culicidae
KW - Diptera
KW - viruses
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - antigenic relationships among
KW - mosquitoes
KW - Tacaiuma viruses
KW - United States of America
KW - Virgin River virus
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584238&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A continuous cell line of a nonhematophagous mosquito, Toxorhynchites amboinensis.
AU - Kuno, G.
JO - In Vitro
JF - In Vitro
Y1 - 1980///
VL - 16
IS - 11
SP - 915
EP - 917
SN - 0073-5655
AD - Kuno, G.: San Juan Laboratories, Center for Disease control, Public Health Service, US Department of Health, Education and Welfare, GPO Box 4532, San Juan, Puerto Rico 00936.
N1 - Accession Number: 19820591404. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A continuous cell line of a non-haematophagous mosquito, Toxorhynchites amboinensis (Doleschall), was obtained by using partially incapacitated but living larvae as the source. The cells were predominantly epithelioid and diploid (2N = 6). Syncytia were occasionally observed in the normal cell cultures.
KW - cell cultures
KW - cell lines
KW - mosquito nets
KW - Culicidae
KW - Diptera
KW - Toxorhynchites amboinensis
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Toxorhynchites
KW - Culicidae
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820591404&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transmission of St. Louis encephalitis virus from Argentina by mosquitoes of the Culex pipiens (Diptera: Culicidae) complex.
AU - Mitchell, C. J.
AU - Monath, T. P.
AU - Sabattini, M. S.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1980///
VL - 17
IS - 3
SP - 282
EP - 285
SN - 0022-2585
AD - Mitchell, C. J.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19800575750. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The results are presented of the first comparative experimental studies on the virus-vector relationships of a strain of St. Louis encephalitis virus (SLE) and a strain of Culex quinquefasciatus Say (pipiens quinquefasciatus), both from Argentina, and of another strain of SLE and a strain of C. pipiens L., from Ohio and Tennessee, respectively; the studies were carried out to determine possible reasons for the difference in disease incidence and severity between temperate North America (where there were severe periodic epidemics) and temperate South America or tropical America (where SLE was endemic and caused occasional isolated cases). All Argentine mosquitoes that fed on chicks infected with either the Ohio or the Argentine strains of SLE became infected 20 days later, regardless of the virus strain used; 87.8 and 89.8% of the Tennessee mosquitoes became infected, but they were less efficient in transmission (58.3% for Ohio virus and 40% for Argentine virus) than the Argentine mosquitoes (90% for Ohio and 90.5% for Argentine virus), possibly because the chick hosts of the Tennessee strain were circulating less virus in their blood. The results indicated that the mosquito strain from Argentina is a very efficient vector of SLE under experimental conditions, and that the Argentine strain of SLE virus does not differ markedly from the temperate North American strain in its ability to infect and be transmitted by mosquitoes of the complex of C. pipiens.
KW - disease transmission
KW - mosquito nets
KW - strain differences
KW - transmission
KW - Culex pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - viruses
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800575750&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of FD and C Red No. 40 on rat intrauterine development.
AU - Collins, T. F. X.
AU - Black, T. N.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1980///
VL - 18
IS - 6
SP - 561
EP - 568
AD - Collins, T. F. X.: Division of Toxicology, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, DC 20204, USA.
N1 - Accession Number: 19811417797. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - Rats were given the food dye FD and C Red No. 40 throughout gestation by stomach tube at 7.5, 15, 30, 100 or 200 mg/kg bodyweight daily or as a 0.2% solution, 260.2 mg/kg bodyweight daily in the drinking water. No toxic, including teratogenic, effect on the foetus was observed.
KW - dyes
KW - FETUS
KW - food additives
KW - pregnancy
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dyestuffs
KW - foetus
KW - food dyes on foetus
KW - gestation
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811417797&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Catecholic and other constituents of the leaves of Toxicodendron radicans and variation of urushiol concentrations within one plant.
AU - Baer, H.
AU - Hooton, M.
AU - Fales, H.
AU - Wu, A.
AU - Schaub, F.
JO - Phytochemistry
JF - Phytochemistry
Y1 - 1980///
VL - 19
IS - 5
SP - 799
EP - 802
SN - 0031-9422
AD - Baer, H.: Food and Drug Administration, Bethesda, MD 20205, USA.
N1 - Accession Number: 19800385320. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Horticultural Science
N2 - Higher concentrations of urushiols (pentadecylcatechols) were found in the younger than in the older leaves of T. radicans. Several sugars, polyols and related products were also identified.
KW - composition
KW - leaves
KW - medicinal plants
KW - medicinal properties
KW - phenolic compounds
KW - sources
KW - plants
KW - Toxicodendron radicans
KW - eukaryotes
KW - Toxicodendron
KW - Anacardiaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Plant Composition (FF040)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800385320&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of diet composition on the growth of rats fed casein or collagen hydrolysates.
AU - Mitchell, G. V.
AU - Jenkins, M. Y.
AU - Vanderveen, J. E.
AU - Ahrens, R. A.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1980///
VL - 21
IS - 6
SP - 893
EP - 899
AD - Mitchell, G. V.: Division of Nutrition, Food and Drug Administration, Dep. Health, Education, and Welfare, Washington, DC 20204, USA.
N1 - Accession Number: 19801411268. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 9000-71-9. Subject Subsets: Human Nutrition
N2 - In a 2 X 4 X 3 design 120 weanling male Sprague-Dawley rats were given freely a diet in which nitrogen source was casein or collagen hydrolysate, and N was 0.8, 1.6, 3.2 or 4.8% of the diet and fat 5, 10 or 20%. Rats given collagen hydrolysate to supply 1.6 and 3.2% N ingested less N than those given casein hydrolysate to supply the same amounts of N. Rats given collagen gained less weight than those given casein when given corresponding amounts of N. Protein efficiency ratio was greatest for casein at 1.6% N and for collagen at 3.2% N. As fat in the diet increased, weight gain of the rats decreased.
KW - casein
KW - collagen
KW - growth
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet modifies effect on growth of casein or collagen hydrolysates
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801411268&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gastrointestinal response in rats to vibration and restraint.
AU - Toraason, M. A.
AU - Badger, D. W.
AU - Wright, G. L.
JO - Environmental Research
JF - Environmental Research
Y1 - 1980///
VL - 23
IS - 2
SP - 341
EP - 347
AD - Toraason, M. A.: US Dep. Health and Human Resources, Public Health Service, Center for Disease Control, National Inst. Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19811421529. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition
N2 - The gastrointestinal response of rats to vibration at 15 Hz, 2.5 gn acceleration was compared with those of control and restraint-stressed rats. In restrained rats, gastric emptying was delayed, there was evidence that the rate of propulsion of a test meal through the ileocaecal valve was decreased and intestinal glucose transport in vitro was changed as indicated by increased serosal:mucosal concentration ratios. Although the values for those responses were not different from control values, similar trends toward delayed gastric emptying and changed transport of glucose were recorded in vibrated rats.
KW - glucose
KW - intestines
KW - restraint
KW - stomach emptying
KW - vibration
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - vibration or restraint on gastric emptying and intestinal glucose transport
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811421529&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and validation of a liquid-chromatographic procedure for serum creatinine.
AU - Spierto, F. W.
AU - MacNeil, M. L.
AU - Culbreth, P.
AU - Duncan, I.
AU - Burtis, C. A.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1980///
VL - 26
IS - 2
SP - 286
EP - 290
SN - 0009-9147
AD - Spierto, F. W.: Center for Disease Control, Public Health Service, US Dep. Health, Education, and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19801402297. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 60-72-5. Subject Subsets: Human Nutrition
N2 - Estimation of creatinine by liquid chromatography was more precise than a method using creatine deiminase (EC 3.5.4.21) and a conventional method also using the Jaffe reagent. The last was not specific and gave erroneously high values in presence of ascorbate, pyruvate, acetone and glucose.
KW - creatinine
KW - estimation
KW - serum
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801402297&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual lipids and proximate analysis of various foods. 5. Candy bars.
AU - Rudolf, T. S.
AU - Sheppard, A. J.
AU - Newkirk, D. R.
AU - Hubbard, W. D.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1980///
VL - 28
IS - 5
SP - 889
EP - 891
SN - 0021-8561
AD - Rudolf, T. S.: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19801416147. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - For part 4 see NAR/A 49, 2212.5. Candy bars, 20 types, had water 1.9 to 17.6, protein 1.4 to 14.2, fat 2.8 to 31.1, ash 0.4 to 2.2 and carbohydrate 52.6 to 86.4%. Maximum values for cholesterol, campesterol, stigmasterol and sitosterol were 33, 4, 19 and 46 mg/100 g, respectively. There was also a wide range in the tabulated fatty acid composition, indicating that mixtures of different oils were used in manufacture.
KW - lipids
KW - sweets
KW - composition of candy bars
KW - lipins
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801416147&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seroepidemiological studies of malaria in pregnant women and newborns from coastal El Salvador.
AU - Campbell, C. C.
AU - Martinez, J. M.
AU - Collins, W. E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1980///
VL - 29
IS - 2
SP - 151
EP - 157
SN - 0002-9637
AD - Campbell, C. C.: Vector Biol. and Control Div., Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education, and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19800872111. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology
N2 - A group of 113 women and their newborns from the coastal area of El Salvador were studied longitudinally to estimate malaria incidence and indirect fluorescent antibody (IFA) response to malaria infection. The district in which the study was conducted had an estimated annual parasite index of 600/1000 inhabitants and all malaria infections were treated immediately with a 4-aminoquinoline. In the 3rd trimester of pregnancy, the IFA response to Plasmodium falciparum was significantly depressed. As a result of antimalarial therapy and depressed immune responsiveness, only approximately 50% of women had a positive titre to P. falciparum or P. vivax at delivery. Malaria IFA crossed the placenta to the foetus with a step-down of about 4-fold dilution, except for the step-up noted in the P. falciparum titre for 17 of 116 newborns. Owing to the over-all low prevalence and intensity of maternal IFA, a titre of at least 1:20 was passed to only 23% (P. vivax) and 45% (P. falciparum) of newborns. Passively-acquired malaria IFA degraded with a half-life estimated between 43 and 52 days. During follow-up of infants to 6 months of age, no protection from malaria resulting from passively-acquired antibody could be demonstrated.
KW - diagnosis
KW - IMMUNODIAGNOSIS
KW - immunofluorescence
KW - parasites
KW - El Salvador
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - fluorescent antibody technique
KW - Haemosporida
KW - IFAT
KW - Salvador
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800872111&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the micro enzyme-linked immunosorbent assay for antibodies to Trypanosoma cruzi.
AU - Spencer, H. C.
AU - Allain, D. S.
AU - Sulzer, A. J.
AU - Collins, W. E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1980///
VL - 29
IS - 2
SP - 179
EP - 182
SN - 0002-9637
AD - Spencer, H. C.: Bureau of Trop. Diseases, Center for Disease Control, Public Health Service, U.S. Dep. of Health, Education and Welfare, Atlanta, GA 30333, USA.
N1 - Accession Number: 19800872114. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology
N2 - Fifty sera collected from residents of the southeastern USA all had reciprocal micro ELISA titres less than or equal to 320 when tested with antigens of Trypanosoma cruzi. Serum samples from 17 patients with T. cruzi infection proven by xenodiagnosis had reciprocal ELISA titres of more than or equal to 1280. Specimens from 302 El Salvador Army recruits were tested by ELISA, IFA (indirect fluorescent antibody test) and CF (complement fixation test). Excellent correlation was observed between results obtained by the 3 serological tests; 62.9% of the samples were negative by each of the 3 tests and 24.5% were positive by all. Over-all, 29.5% of the sera were positive for antibodies to T. cruzi by ELISA, 29.5% by IFA and 31.5% by CF. The results suggest that the micro ELISA is a promising serological test for measuring antibodies to T. cruzi in individuals and in populations. [AS]
KW - diagnosis
KW - ELISA
KW - IMMUNODIAGNOSIS
KW - parasites
KW - man
KW - protozoa
KW - Trypanosoma cruzi
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - enzyme linked immunosorbent assay
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800872114&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Yellow fever in the Gambia, 1978-1979: epidemiologic aspects with observations on the occurrence of Orungo virus infections.
AU - Monath, T. P.
AU - Craven, R. B.
AU - Adjukiewicz, A.
AU - Germain, M.
AU - Francy, D. B.
AU - Ferrara, L.
AU - Samba, E. M.
AU - N'jie, H.
AU - Cham, K.
AU - Fitzgerald, S. A.
AU - Crippen, P. H.
AU - Simpson, D. I. H.
AU - Bowen, E. T. W.
AU - Fabiyi, A.
AU - Salaun, J. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1980///
VL - 29
IS - 5
SP - 912
EP - 928
SN - 0002-9637
AD - Monath, T. P.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Department of Health, Education, and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810580229. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - An epidemic of yellow fever occurred in the Gambia between May 1978 and January 1979. Retrospective case-finding methods and active surveillance led to the identification of 271 clinically suspected cases. A confirmatory or presumptive laboratory diagnosis was established in 94 cases. The earliest serologically documented case occurred in June 1978, at the extreme east of the Gambia. Small numbers of cases occurred in August and September. The epidemic peaked in October, and cases continued to occur at a diminishing rate until January, when a mass vaccination campaign was completed. The outbreak was largely confined to the eastern half of the county (MacCarthy Island and Upper River Divisions). In nine survey villages in this area (total population 1531), the attack rate was 2.6-4.4%, with a mortality rate of 0.8%, and a case-fatality rate of 19.4%. If these villages are representative of the total affected region, there may have been as many as 8400 cases and 1600 deaths during the outbreak. The disease incidence was highest in the 0- to 9-year age group (6.7%) and decreased with advancing age to 1.7% in persons over 40 years. Overall, 32.6% of survey village inhabitants had yellow fever complement-fixing (CF) antibodies. The prevalence of antibody patterns indicating primary yellow fever infection decreased with age, in concert with the disease incidence. The overall inapparent:apparent infection ratio was 12:1. In persons with serological responses indicating flaviviral superinfection, the inapparent:apparent infection ratio was 10 times higher than in persons with primary yellow fever infection. Sylvatic vectors of yellow fever virus, principally mosquitoes of the group of Aedes furcifer (Edw.) and A. taylori Edw. and A. luteocephalus (Newst.) are believed to have been responsible for transmission, at least at the beginning of the outbreak. Eighty-four per cent. of wild monkeys shot in January 1979 had yellow fever neutralising antibodies, and 32% had complement-fixing antibodies. Domestic adults of A. aegypti (L.) were absent or present at very low indices in many severely affected villages. In January, however, A. aegypti-borne yellow fever 2.5 months into the dry season was documented by the isolation of yellow fever virus from a sick man and from this vector species in the absence of sylvatic vectors. Thus, in villages where the classical urban vector was abundant, interhuman transmission by A. aegypti occurred and continued into the dry season. A mass vaccination campaign, begun in December, was completed on 25 January, with over 95% coverage of the Gambian population. A seroconversion rate of 93% was determined in a group of vaccines. This outbreak emphasises the continuing public health importance of yellow fever in West Africa and points out the need for inclusion of 17D yellow fever vaccination in future programmes of multiple immunisation.
KW - groups
KW - mosquito nets
KW - yellow fever
KW - Gambia
KW - Aedes aegypti
KW - Aedes furcifer
KW - Aedes luteocephalus
KW - Aedes taylori
KW - Culicidae
KW - Diptera
KW - man
KW - viruses
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - mosquitoes
KW - The Gambia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810580229&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative aspects of the infection of Simulium ochraceum by Onchocerca volvulus: the relation of skin microfilarial density to vector infection.
AU - Campbell, C. C.
AU - Collins, R. C.
AU - Huong, A. Y.
AU - Figueroa Marroquin, H.
JO - Tropenmedizin und Parasitologie
JF - Tropenmedizin und Parasitologie
Y1 - 1980///
VL - 31
IS - 4
SP - 475
EP - 478
AD - Campbell, C. C.: Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810580547. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology; Helminthology
N2 - In Guatemala, 16 wild adults of Simulium ochraceum Wlk. were permitted to feed on a 15 X 15-in. grid delineated on the back of each of 13 persons infected with Onchocerca volvulus. Based on 6 skin biopsies, the mean microfilarial density in these study participants ranged from 1.256 to 111.824 microfilariae/mg of skin. The flies were dissected 6-10 h after feeding and the number of microfilariae in the blood-meal and escaping from the mid-gut into the thoracic musculature were counted. An almost linear relationship was found between the mean skin microfilarial density and the mean microfilarial uptake by S. ochraceum. An even stronger relationship existed between the mean microfilarial density and the mean number of microfilariae escaping from the mid-gut. Since the approximate 1:1 ratio observed between the number of microfilariae escaping from the mid-gut and the subsequent number of infective (third-stage) larvae had been previously demonstrated, it could be concluded that a similar linear relationship exists between microfilarial skin densities and the number of third-stage larvae available for transmission of O. volvulus by the Guatemalan vector.
KW - epidemiology
KW - helminths
KW - infections
KW - parasites
KW - Guatemala
KW - Diptera
KW - insects
KW - man
KW - Nematoda
KW - Onchocerca volvulus
KW - Simuliidae
KW - Simulium ochraceum
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Diptera
KW - Simulium
KW - Simuliidae
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - blackflies
KW - buffalo gnats
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - uptake from man
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810580547&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Wine versus ethanol in human nutrition. 4. Zinc balance.
AU - McDonald, J. T.
AU - Margen, S.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1980///
VL - 33
IS - 5
SP - 1096
EP - 1102
SN - 0002-9165
AD - McDonald, J. T.: Metabolic Univ, United States Public Health Service Hospital, 15th Ave., and Lake Street, San Francisco, Calif. 94118, USA.
N1 - Accession Number: 19801408341. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 64-17-5, 7440-66-6. Subject Subsets: Human Nutrition
N2 - For part 3 see NAR/A 50, 1331. 4. Six healthy young men participated in a metabolic balance study to assess the effects of wine versus ethanol on absorption of different elements. During each of 4 18-day experimental periods, the subjects were given a controlled diet plus a daily allowance of 1 litre of one of the following test beverages, given in random order: Zinfandel wine, dealcoholized Zinfandel wine, an aqueous ethanol solution and deionized water. Urinary zinc was significantly more with wine and ethanol than with the nonalcoholic beverages, suggesting that alcohol may affect the metabolism or renal conservation mechanism for Zn. The possibility of muscle catabolism due to alcohol ingestion is discussed. There was increased absorption and, perhaps also, decreased endogenous secretion of Zn with the wine and dealcoholized wine compared with ethanol and deionized water. This presumably was due to the nonalcoholic constituents of wine. Analysis of Zn in whole sweat after strenuous exercise revealed that a considerable amount of this ion can be lost during excessive sweating.
KW - ethanol
KW - wines
KW - zinc
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ethyl alcohol
KW - wine or ethanol on zinc balance
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801408341&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elemental content of predigested liquid protein products.
AU - Jones, A. O. L.
AU - Jacobs, R. M.
AU - Fry, B. E., Jr.
AU - Jones, J. W.
AU - Gould, J. H.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1980///
VL - 33
IS - 12
SP - 2545
EP - 2550
SN - 0002-9165
AD - Jones, A. O. L.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19811418174. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9000-70-8. Subject Subsets: Human Nutrition
N2 - The mineral content of 8 commercial gelatin liquid products used to reduce bodyweight was poor. It is suggested that use of those products as the only food will give an inadequate intake of all the essential elements.
KW - gelatin
KW - minerals
KW - liquid protein
KW - minerals in gelatin liquid products
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811418174&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory and nutritional aspects of fructose and sugar alcohols in foods.
AU - Frattali, V. P.
JO - Food Technology
JF - Food Technology
Y1 - 1980///
VL - 34
IS - 1
SP - 67
EP - 69
AD - Frattali, V. P.: Dep. Nutrition and Food Sciences, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19801406870. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 57-48-7. Subject Subsets: Human Nutrition
KW - food additives
KW - food legislation
KW - fructose
KW - reviews
KW - sugar alcohols
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fruit sugar
KW - ketohexose
KW - laevulose
KW - levulose
KW - review of regulatory and nutritional aspects of fructose and sugar alcohols in foods
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801406870&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sugar and caries: regulation of a nonmortal hazard.
AU - Miller, S. A.
JO - Food Technology
JF - Food Technology
Y1 - 1980///
VL - 34
IS - 1
SP - 77
EP - 80
AD - Miller, S. A.: Bureau of Foods, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19801406873. Publication Type: Journal Article. Language: English. Number of References: 1 ref. Subject Subsets: Human Nutrition
KW - dental caries
KW - sugars
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - caries
KW - sugar and caries
KW - teeth caries
KW - tooth decay
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801406873&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies of colonization of El Salvador strains of Anopheles pseudopunctipennis pseudopunctipennis.
AU - Darsie, R. F., Jr.
AU - Lopez, G. A.
JO - Mosquito News
JF - Mosquito News
Y1 - 1980///
VL - 40
IS - 2
SP - 194
EP - 199
AD - Darsie, R. F., Jr.: Central America Research Station, Public Health Service, US Department of Health, Education and Welfare, San Salvador, El Salvador.
N1 - Accession Number: 19810584128. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Two colonies of Anopheles pseudopunctipennis pseudopunctipennis Theo. have been established in El Salvador using induced copulation. The Ilopango strain was initiated with immature stages collected from a highland lake. The Huiza strain was started with females captured near a coastal river. A study of stenogamy began with holding adult males and females together in emergence cages. Natural mating was achieved, and the deposition of viable eggs took place on a substrate of moist earth wetted with larval essence.
KW - mosquito nets
KW - rearing techniques
KW - techniques
KW - El Salvador
KW - Anopheles pseudopunctipennis
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles pseudopunctipennis
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Anopheles pseudopunctipennis pseudopunctipennis
KW - mosquitoes
KW - Salvador
KW - Techniques and Methodology (ZZ900)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584128&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cadmium and lead content of soybean products.
AU - Braude, G. L.
AU - Nash, A. M.
AU - Wolf, W. J.
AU - Carr, R. L.
AU - Chaney, R. L.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1980///
VL - 45
IS - 5
SP - 1187
EP - 1189; 1199
SN - 0022-1147
AD - Braude, G. L.: Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19801414171. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Soya beans grown on soil, cadmium 2.8 mu g/g, to which sewage sludge had been applied, was fractionated to simulate food processing. Protein-enriched fractions had most Cd, oil had least and all values were greater than control values. Commercial soya bean products for human consumption had Cd 0.04 to 0.08 and lead 0.07 to 0.27 mu g/g. Increased application of Cd to soils may be hazardous but commercial soya bean products do not have excessive Cd or Pb.
KW - cadmium
KW - lead
KW - soyabeans
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - cadmium and lead in soya bean products
KW - soybeans
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The structure of a colorado tick fever ecosystem.
AU - Carey, A. B.
AU - McLean, R. G.
AU - Maupin, G. O.
JO - Ecological Monographs
JF - Ecological Monographs
Y1 - 1980///
VL - 50
IS - 2
SP - 131
EP - 151
SN - 0012-9615
AD - Carey, A. B.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, USDH/EW, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19800577814. Publication Type: Journal Article. Language: English. Number of References: 84 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The habitat hyperspace of a south-facing slope ecosystem in the Rocky Mountain National Park, Colorado, was characterised by 2 major gradients, soil depth and soil moisture. Richardson's ground squirrels (Spermophilus richardsonii) were limited in their distribution by areas of shallow soil, and excluded golden-mantled ground squirrels (S. lateralis) from areas of deep soil. The habitat hypervolume of the latter squirrel included that of the least chipmunks (Eutamias minimus); the golden-mantled ground squirrels suppressed the population of least chipmunks. Deer mice (Peromyscus maniculatus), least chipmunks and golden-mantled ground squirrels were the principal hosts of larvae of Dermacentor andersoni Stiles. The golden-mantled ground squirrels and least chipmunks were the principal hosts of nymphs of D. andersoni. The circulation of Colorado tick fever virus was maintained through the interactions of D. andersoni, least chipmunks and golden-mantled ground squirrels. Areas of abundance of D. andersoni were accurately described by a discriminant function of 5 easily measured habitat hyperspace variables, areas of virus activity with 7 variables.
KW - ecosystems
KW - Colorado
KW - USA
KW - Acari
KW - Colorado tick fever virus
KW - Dermacentor andersoni
KW - Peromyscus maniculatus
KW - Spermophilus lateralis
KW - squirrels
KW - viruses
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Peromyscus
KW - Sigmodontinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Spermophilus
KW - Sciuridae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Eutamias minimus
KW - United States of America
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat.
AU - Taylor, J. M.
AU - Weinberger, M. A.
AU - Friedman, L.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1980///
VL - 54
IS - 1
SP - 57
EP - 75
SN - 0041-008X
AD - Taylor, J. M.: Division of Toxicology, Food and Drug Administration, 200 "C" Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19801413993. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 81-07-2. Subject Subsets: Human Nutrition
N2 - Charles River CD strain rats exposed in utero, the offspring of parents treated from weaning through mating, gestation and lactation, were given diets with sodium saccharin 0, 0.01, 0.1, 1.0, 5.0 or 7.5%. Calcium cyclamate was a reference compound at 5.0%. Groups of 96 weanling rats had the same diet as their parents. The study was continued until the number of survivors in a group fell to 20% with the last survivors being killed about 28 months after the first weanlings were selected for the chronic study. Treatment-related effects were not observed in hematological values, organ weights or survival. Average weaning weights decreased in litters from parents given 5.0 or 7.5% sodium saccharin or 5.0% calcium cyclamate. The incidence and types of neoplasms and nonneoplastic lesions, other than urinary bladder neoplasms and hyperplasia, were typical of the old rat and were not related to treatment. An increased incidence of urinary bladder hyperplasia occurred in female rats given 7.5% sodium saccharin, but the lesion was not morphologically precancerous. Urinary bladder neoplasms increased in the males given 7.5% sodium saccharin. A total of 11 bladder neoplasms occurred after 18 months; 9 in those given 7.5% and one each in the control and 5.0% groups. There were 9 neoplasms in males and 2 in females. Histologically, 6 of the neoplasms were benign and 5 malignant. All the malignant neoplasms occurred in the group given 7.5% saccharin. The occurrence of the urinary bladder neoplasms could not be related to such predisposing factors as gross calculi, parasites or hyperplasia.
KW - BLADDER
KW - carcinogens
KW - FETUS
KW - saccharin
KW - uterus
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - foetus
KW - toxicity and carcinogenicity to bladder of exposure in uterus to sodium saccharin
KW - urinary bladder
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic low-level lead toxicity in the rat. 1. Maternal toxicity and perinatal effects.
AU - Kimmel, C. A.
AU - Grant, L. D.
AU - Sloan, C. S.
AU - Gladen, B. C.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1980///
VL - 56
IS - 1
SP - 28
EP - 41
SN - 0041-008X
AD - Kimmel, C. A.: Division of Teratogenesis Research, National Center for Toxicological Research, Jefferson, Ark. 72079, USA.
N1 - Accession Number: 19811419228. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition; Veterinary Science
N2 - 1. Weanling female rats were provided with semipurified diets containing no detectable Pb, and drinking water containing Pb 0.5, 5, 25, 50 or 250 mu g/g (as lead acetate). Rats were exposed to lead acetate for 6 to 7 weeks, then mated and exposed continuously throughout gestation and lactation. No significant change in food or water intake was noted in any group. Female rats on Pb 50 and 250 mu g/g showed significant growth retardation within 1 to 3 weeks after exposure began. Vaginal opening was significantly delayed with Pb 50 and 250 mu g/g, and to a smaller extent with 25 mu g/g. The amount of Pb exposure did not affect the ability to conceive, to carry a normal litter to term or to deliver the young. The percentage of malformed foetuses, resorptions and deaths of young to weaning were unaffected by Pb exposure. Body lengths of female offspring with 250 mu g/g were significantly shorter than those of controls, and there was a tendency for all young in that group to be smaller. The estimated dose of Pb consumed (mg/kg) indicated that groups were exposed to different amounts of Pb, and tissue (blood, brain and bone) Pb concentrations indicated dose-related patterns. Urinary aminolaevulinic acid concentrations were significantly dose-related and were significantly correlated with blood Pb concentrations. Maternal toxicity occurred in groups exposed to 25 mu g/g or more and was associated with a minimum blood Pb concentration of 20 mu g/100 ml.
KW - CONGENITAL ABNORMALITIES
KW - FETUS
KW - lactation
KW - lead
KW - Newborn animals
KW - poisoning
KW - pregnancy
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth defects
KW - congenital malformations
KW - foetus
KW - gestation
KW - maternal toxicity and perinatal effects of lead
KW - toxicosis
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic low-level lead toxicity in the rat. 2. Effects on postnatal physical and behavioral development.
AU - Grant, L. D.
AU - Kimmel, C. A.
AU - West, G. L.
AU - Martinez-Vargas, C. M.
AU - Howard, J. L.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1980///
VL - 56
IS - 1
SP - 42
EP - 58
SN - 0041-008X
AD - Grant, L. D.: Division of Teratogenesis Research, National Center for Toxicological Research, Jefferson, Ark. 72079, USA.
N1 - Accession Number: 19811419229. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition; Veterinary Science
N2 - 2. The diets and rats are as described in the preceding abst. After exposure to lead for 6 to 7 weeks the female rats were mated with unexposed male rats and exposure continued throughout pregnancy and lactation. At 21 days old offspring were weaned onto the same Pb concentration their mothers had been given, and exposure continued until they were killed at 6 or 9 months old. Significant depression occurred in bodyweight of offspring exposed to Pb 50 and 250 mu g/g. Clinical signs of respiratory infection, as well as poor fur condition, tail-tip necrosis and sialodacryoadenitis were noted with 250 mu g/g. Highly significant delays in age at vaginal opening were noted with Pb 25, 50 and 250 mu g/g. Surface righting and air righting were delayed with 50 and 250 mu g/g. Locomotor development was unaffected except for an increase in pivoting with 250 mu g/g at 14 days old. Postweaning activity was not changed when measured in the open field or the circular photocell activity cage and evaluations of motor coordination using the rotorod test showed no effects of Pb. Food and water consumption based on bodyweight were unchanged. Overall, the "lowest effect level" for Pb, using chronic oral exposure was 25 mu g/g, an amount associated with changes in reproductive development. In other reports from this study, immune function and performance of an operant task in adults were changed at 25 mu g/g (blood Pb 20 to 40 mu g/100 ml), and renal morphology after 9 months of exposure was changed at 5 mu g/g (blood Pb 10 to 16 mu g/100 ml). The importance of reporting blood and tissue Pb concentrations for comparing Pb dose-effect among studies is emphasized.
KW - Animal behaviour
KW - behaviour
KW - growth
KW - lactation
KW - lead
KW - Newborn animals
KW - poisoning
KW - Postnatal development
KW - pregnancy
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal behavior
KW - behavior
KW - gestation
KW - maternal toxicity and physical and behavioural toxic effects of lead in progeny
KW - toxicosis
KW - Physiology of Human Nutrition (VV120)
KW - Animal Behaviour (LL300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic low-level lead toxicity in the rat. 3. An integrated assessment of long-term toxicity with special reference to the kidney.
AU - Fowler, B. A.
AU - Kimmel, C. A.
AU - Woods, J. S.
AU - McConnell, E. E.
AU - Grant, L. D.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1980///
VL - 56
IS - 1
SP - 59
EP - 77
SN - 0041-008X
AD - Fowler, B. A.: Division of Teratogenesis Research, National Center for Toxicological Research, Jefferson, Ark. 72079, USA.
N1 - Accession Number: 19811419230. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition; Veterinary Science
N2 - 3. Male and female rats from mothers exposed to Pb before and during pregnancy and lactation at 0, 0.5, 5, 25, 50 and 250 mu g/g as lead acetate in drinking water were fed on the same respective diets for 6 or 9 months. Bodyweights of rats were not significantly different from controls at 6 months; however, female bodyweights were significantly decreased with Pb 250 mu g/g for 9 months. In male rats at 9 months old, spleen weights were significantly increased with Pb 250 mu g/g and kidney weights were increased with 0.5 mu g/g and above; in female rats the liver, pituitary and heart weights were affected at 250 mu g/g. No significant Pb effect was found in sperm counts or sperm morphology, haematology profiles or serum chemistry. Blood, brain, femur and kidney Pb values and urinary aminolaevulinic acid excretion were all significantly dose-related. Histopathological lesions were noted in the spleen at 250 mu g/g and in the kidney. These effects were more after 9 months of exposure. Ultrastructural studies revealed mitochondrial swelling and the presence of increased numbers of lysosomes within renal proximal tubule cells. Energy-dispersive X-ray microanalysis of adjacent sections showed the highest intracellular Pb concentrations in nuclear inclusion bodies within renal proximal tubule cells. Inhibition of renal mitochondrial respiration for succinate and NAD-linked substrates was found at 50 and 250 mu g/g exposure for 9 months but not for 6 months. Mitochondrial delta -aminolaevulinic acid synthetase and ferrochelatase but not delta -aminolaevulinic dehydratase, were also inhibited with those amounts of Pb for 9 months. The smallest amount of exposure resulting in a detectable effect of Pb (cytomegaly/karyomegaly in renal proximal tubule cells) was 5 mu g/g associated with a median blood Pb concentration of 11 mu g/100 ml.
KW - kidney diseases
KW - kidneys
KW - lead
KW - Pathology
KW - poisoning
KW - Postnatal development
KW - Tissue ultrastructure
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - kidney disorders
KW - lead exposure on kidneys
KW - nephropathy
KW - renal diseases
KW - toxicosis
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicity and teratogenicity of food additive chemicals in the developing chicken embryo.
AU - Verrett, M. J.
AU - Scott, W. F.
AU - Reynaldo, E. F.
AU - Alterman, E. K.
AU - Thomas, C. A.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1980///
VL - 56
IS - 2
SP - 265
EP - 273
SN - 0041-008X
AD - Verrett, M. J.: Division of Toxicology, Bureau of Foods, Food and Drug Administration, Dep. Health and Human Services, Washington, D.C. 20204, USA.
N1 - Accession Number: 19811420564. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - The toxicity of 80 chemicals used as food additives was studied using developing chicken embryos. These were injected via the air cell or via the yolk after preincubation for 0 and 96 h. For each condition, at least 100 embryos/dose amount were treated at a minimum of 5 dose amounts. Amounts tested ranged from 0.50 to 75 mg/egg; the maximum volume injected was 100 mu l. No especially toxic compounds were found but there was a range of LD50 values. Ten chemicals produced significant numbers of abnormal birds in one or more of the test conditions. Results indicate that the chicken embryo test can demonstrate the teratogenic potential of compounds, is selective and does not respond nonspecifically to any agent introduced during development. The test may be useful for screening large numbers of compounds.
KW - food additives
KW - teratogenesis
KW - toxicity and teratogenicity of food additives (chicken embryo)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Additives (QQ130)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fermentative reduction of phytate in rye, white, and whole wheat breads.
AU - Harland, B. F.
AU - Harland, J.
JO - Cereal Chemistry
JF - Cereal Chemistry
Y1 - 1980///
VL - 57
IS - 3
SP - 226
EP - 229
SN - 0009-0352
AD - Harland, B. F.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19801410233. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 83-86-3. Subject Subsets: Human Nutrition
N2 - Bread made with rye and wheat, all purpose and whole wheat flours contained phytate 0.78, 0.03 and 0.64% and bread made after fermenting the dough for 8 h had 0.21, 0.02 and 0.43%, respectively. Fermentation for 2, 4 and 8 h progressively decreased the phytate content and increasing the amount of yeast decreased values in rye bread. Values are tabulated for Ca, P, Mg, Cu, Fe, Mn, Zn and phytate:zinc molar ratio in the breads. Whole wheat bread had most P, Mg, Fe, Mn and Zn.
KW - bread
KW - fermentation
KW - phytic acid
KW - fermentative reduction of phytate in bread
KW - inositol hexaphosphate
KW - phytate
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of heat exposure on in vitro intestinal transport and utilization of glucose in the rat.
AU - Toraason, M. A.
AU - Knecht, E. A.
AU - Wright, G. L.
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
Y1 - 1980///
VL - 58
IS - 4
SP - 424
EP - 428
SN - 0008-4212
AD - Toraason, M. A.: US Dep. Health, Education, and Welfare, Public Health Service, Cincinnati, OH 45226 USA.
N1 - Accession Number: 19801407934. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 15 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition
N2 - Intestinal transport and utilization of glucose were studied in vitro in rats exposed chronically to 34 deg C. Despite mucosal tissue per cm being significantly reduced after 7 and 14 days of exposure, no differences from control values were noted in final serosal to mucosal fluid glucose concentrations ratios obtained from everted sac preparations. Estimations on 40-cm jejunal segments perfused in vitro at days 13 to 15 showed a reduction in the rate of glucose absorption per cm intestine; glucose absorption per g tissue was not changed in heat-exposed rats. At the same time, glucose secretion at the serosal surface was unchanged when calculated per cm intestine and increased when calculated per g dry tissue. The utilization of glucose by the intestine was significantly reduced whether expressed for intestinal length or for intestinal weight. The glucose concentration of the tissue water was increased in intestinal segments of heat-exposed rats after 60 min of perfusion. The decrease in glucose uptake per cm intestine was attributed to the decrease in mucosal tissue. Increased tissue glucose concentration and translocation of glucose to the serosal surface were attributed, at least in part, to the decreased rate of glucose metabolism in intestines of heat-exposed rats.
KW - glucose
KW - heat stress
KW - intestines
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - intestinal glucose transport and utilization in heat stress
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Haiti nutrition status survey, 1978.
AU - Graitcer, P. L.
AU - Gedeon, M. A.
AU - Beausset, I. De
AU - Duckett, E. M.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1980///
VL - 58
IS - 5
SP - 757
EP - 765
SN - 0042-9686
AD - Graitcer, P. L.: Bureau of Smallpox Eradication, Center for Disease Control, Public Health Service, Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19811417446. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - In the Haiti National Nutrition Survey in 1978, of 5353 preschool children surveyed 6% were severely wasted, with less than 80% of reference median bodyweight-for-height. The incidence of stunting, with less than 90% of reference median height-for-age, was highest, over 40%, at 48 to 59 months old. Causes of malnutrition could not be listed in the present cross-sectional survey but the baseline data indicated that undernutrition was a main problem, that it was most severe at 12 to 23 months old and that it was distributed evenly through all the rural departements in Haiti.
KW - nutrition surveys
KW - Haiti
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Least Developed Countries
KW - Developing Countries
KW - Haiti nutrition survey
KW - nutritional surveys
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional status of preschool children in Togo, 1976-77.
AU - Stetler, H. C.
AU - Ayeboua, A.
AU - Brink, E. W.
AU - Agle, A. N.
AU - Staehling, N. W.
AU - Lane, J. M.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1980///
VL - 58
IS - 6
SP - 889
EP - 895
SN - 0042-9686
AD - Stetler, H. C.: Bureau of Smallpox Eradication, Center for Disease Control, Public Health Service, Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19811419066. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - Data were for 6120 infants and children 6 to 72 months old at 163 rural village and 41 urban quarters in Togo, West Africa, during the 1976-77 National Nutritional Survey. Hb was estimated for a fifth of them. Taking 80% of the reference median bodyweight-for-height as the cut-off point, 2% were acutely undernourished. Taking 90% of the reference median height-for-age, 19.1% were chronically undernourished. Incidence of both types of undernutrition was significantly higher in the northern rural areas than in the urban areas. Incidence of anaemia was 58.6% on average, highest in the north. Togo preschool children of high socioeconomic status had a significantly higher nutritional state than those of the present survey and nearly equivalent to that of a USA reference population. The method of survey was economical in money, time and staff;it provided rapidly the objective data on the extent and distribution of protein-energy malnutrition and anaemia. The other measurements were of arm circumference and foot oedema.
KW - children
KW - nutritional state
KW - Togo
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Francophone Africa
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - nutritional state of children in Togo
KW - nutritional status
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of gel permeation chromatography and nonaqueous reverse phase chromatography to high pressure liquid chromatographic determination of retinyl palmitate in fortified breakfast cereals.
AU - Landen, W. O., Jr.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1980///
VL - 63
IS - 1
SP - 131
EP - 136
AD - Landen, W. O., Jr.: Food and Drug Administration, 880 W. Peachtree St., NW, Atlanta, GA 30309, USA.
N1 - Accession Number: 19801403985. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 79-81-2. Subject Subsets: Human Nutrition
N2 - The estimation of retinyl palmitate by high-pressure liquid chromatography is described. Values for fortified breakfast cereals tended to be greater than those obtained by the official AOAC method and by ultraviolet spectrophotometry (NAR 35, 1988). Vitamin A in 15 cereals ranged from 34 to 194% of the declared content.
KW - cereals
KW - retinyl palmitate
KW - estimation and content of retinyl palmitate in breakfast cereals
KW - retinol palmitate
KW - vitamin A palmitate
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differential pulse polarographic determination of saccharin in foods: collaborative study.
AU - Holak, W.
AU - Krinitz, B.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1980///
VL - 63
IS - 2
SP - 163
EP - 167
AD - Holak, W.: Food and Drug Administration, 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19801408068. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 81-07-2. Subject Subsets: Human Nutrition
KW - estimation
KW - saccharin
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801408068&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of foods for lead, cadmium, copper, zinc, arsenic, and selenium, using closed system sample digestion: collaborative study.
AU - Holak, W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1980///
VL - 63
IS - 3
SP - 485
EP - 495
AD - Holak, W.: Food and Drug Administration, 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19801409840. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7440-38-2, 7440-43-9, 7440-50-8, 7439-92-1, 7782-49-2, 7440-66-6. Subject Subsets: Human Nutrition
N2 - The food sample was digested with HNO3 under pressure in a special vessel obtained commercially. Cd, Pb and Cu were estimated by anodic stripping voltammetry, As, Se and Zn by absorption spectrophotometry. Respective recoveries were 89, 93, 108, 100, 95 and 97%. The method was adopted as official first action for all except Cu.
KW - arsenic
KW - cadmium
KW - copper
KW - foods
KW - lead
KW - selenium
KW - zinc
KW - estimation of food minerals
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801409840&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analytical methodology and reported findings of polycyclic aromatic hydrocarbons in foods.
AU - Howard, J. W.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1980///
VL - 63
IS - 5
SP - 1077
EP - 1104
AD - Howard, J. W.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19801416913. Publication Type: Journal Article. Language: English. Number of References: 208 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - contaminants
KW - foods
KW - hydrocarbons
KW - reviews
KW - analytical techniques
KW - review of analytical methods for and values of polycyclic hydrocarbons in foods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801416913&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A case-control study of large bowel cancer in Japan.
AU - Haenszel, W.
AU - Locke, F. B.
AU - Segi, M.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 64
IS - 1
SP - 17
EP - 22
SN - 0027-8874
AD - Haenszel, W.: Biometry Branch, NCI, Landow Building, Room 5C03, National Insts. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19801410622. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - Examination of reports on diet and other environmental factors in 588 patients with colorectal cancer and 1176 controls in hospital in 3 prefectures of Japan showed weak (not significant) positive effects for social class and urbanization. The significant associations of colorectal cancer with consumption of beef, string beans or starches described for Hawaiian Japanese were not reproduced. An association with hakusal (cabbage) agreed with reports on a negative association with cruciferous vegetables. An analysis of the subset of cases in the low rectum yielded results similar to those for the total series. The failure to uncover important food effects in Japan is attributed to the difficulty of detecting case-control differences in areas with homogeneous diet practices.
KW - colon
KW - neoplasms
KW - rectum
KW - Japan
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - cancers
KW - diet and large bowel cancer in Japan
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801410622&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Glucose turnover and gluconeogenesis during hypocaloric glucose infusion in tumor-bearing F344 male rats.
AU - Lowry, S. F.
AU - Norton, J. A.
AU - Gorschboth, C. M.
AU - Brennan, M. F.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 64
IS - 2
SP - 291
EP - 296
SN - 0027-8874
AD - Lowry, S. F.: Bldg. 10, Room 10N111, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19801412515. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition
N2 - Glucose turnover ([3-3H]glucose) and gluconeogenesis from alanine ([U-14C]alanine) were estimated in nontumour-bearing (NTB) and tumour-bearing (TB) inbred F344 male rats during starvation and in response to graded infusion of glucose. All groups showed glucose turnover appropriate to the prevailing steady-state plasma glucose. Whereas NTB showed greatest suppression of gluconeogenesis from alanine at infusion rates of 0.39 mg/100 g total bodyweight min, TB rats suppressed alanine-to-glucose conversion only at a glucose infusion rate of 0.71 mg/100 g total bodyweight min. Glucose clearance was consistently higher in TB groups but did not change in NTB or TB groups during infusion. Blood lactate increased in response to glucose infusion in TB rats only.
KW - gluconeogenesis
KW - glucose
KW - tumours
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - glucose turnover and gluconeogenesis during glucose infusion in tumour bearers
KW - tumors
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801412515&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Requirement of essential fatty acids in the diet for development of the mouse mammary gland.
AU - Knazek, R. A.
AU - Liu, S. C.
AU - Bodwin, J. S.
AU - Vonderhaar, B. K.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 64
IS - 2
SP - 377
EP - 379
SN - 0027-8874
AD - Knazek, R. A.: Bldg. 10, Room 5B36, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health, Education, and Welfare, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19801412517. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The ductal system of mammary glands in C3H mice which were started on diets deficient in essential fatty acid (EFA) 1 to 2 weeks after weaning developed at a normal rate. The alveolar structures began to disappear in the mice after 17 weeks on the EFA-deficient diet. Injection of linoleic acid subcutaneously prevented the atrophic process. Alveoli were also absent in the glands of multiparous mice which were reared for 32 weeks on the EFA-deficient diet. When the EFA-deficient diet was started in females during midpregnancy and maintained continuously thereafter, ductal and alveolar structures did not develop in the mammary glands of the offspring.
KW - development
KW - essential fatty acids
KW - fatty acids
KW - mammary glands
KW - requirements
KW - MICE
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - requirement of essential fatty acids for development of mammary gland
KW - Physiology of Human Nutrition (VV120)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801412517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of retinyl acetate on the incidence of mammary carcinomas and hepatomas in mice.
AU - Maiorana, A.
AU - Gullino, P. M.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 64
IS - 3
SP - 655
EP - 663
SN - 0027-8874
AD - Maiorana, A.: Lab. Pathophysiology, Division of Cancer Biology and Diagnosis, National Cancer Inst. (NCI), NIH, Public Health Service, US Dep. Health, Education and Welfare, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19801412960. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 127-47-9. Subject Subsets: Human Nutrition
N2 - Female C3H-Avy mice were given a stock diet supplemented with retinyl acetate (RA) beadlets at concentrations of 83, 41 and 21 mg/kg diet. Control mice received stock diet supplemented with placebo beadlets. The RA diet was started at conception in one group of mice (mothers were given RA from the time of mating). Two other groups of mice were given the RA diet at weaning or at 3 months old. Mice were killed and examined 1 month after the appearance of the first mammary tumour or at 15 months old if no tumour developed. No significant difference in incidence of mammary carcinomata was found between control mice and those given RA. The incidence was 80 to 90% in all groups. The number of tumours per mouse (1.6 to 2.1) and the tumour latency period (10.2 to 11.6 months) were not influenced by RA in the diet. Two unexpected observations were that control mice killed at 12 months old or older showed a 70% incidence of hepatomata, whereas the incidences were about 11, 17 and 46% in mice given RA 83, 41 and 21 mg/kg diet, respectively, and that severe damage to most articulations was induced by RA, even at 21 mg/kg diet, which did not cause any other sign of toxicity.
KW - mammary glands
KW - neoplasms
KW - retinyl acetate
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - retinol acetate
KW - retinyl acetate on incidence of mammary cancer
KW - vitamin A acetate
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801412960&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates.
AU - Sieber, S. M.
AU - Correa, P.
AU - Dalgard, D. W.
AU - McIntire, K. R.
AU - Adamson, R. H.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 65
IS - 1
SP - 177
EP - 183
SN - 0027-8874
AD - Sieber, S. M.: Lab. Chemical Pharmacology, Division of Cancer Treatment, National Cancer Inst. (NCI), National Insts. Health, Public Health Service, US Dep. Health and Human Services, Bethesda, MD 20205, USA.
N1 - Accession Number: 19801413361. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 14901-08-7. Subject Subsets: Human Nutrition
N2 - Cycasin, present in seeds of Cycas circinalis, and its aglycone were toxic to monkeys.
KW - cycasin
KW - toxicity (monkey)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19801413361&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Water-soluble, dextran-linked retinal: preparation, vitamin A-like activity in rats, and effects on melanoma cells.
AU - Pitha, J.
AU - Zawadzki, S.
AU - Chytil, F.
AU - Lotan, D.
AU - Lotan, R.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1980///
VL - 65
IS - 5
SP - 1011
EP - 1015
SN - 0027-8874
AD - Pitha, J.: Section of Macromolecules, National Inst. Aging, National Insts. Health, Public Health Service, US Dep. Health and Human Services, Gerontology Research Center, Baltimore City Hospitals, Baltimore, Md. 21224, USA.
N1 - Accession Number: 19811421931. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition
N2 - A new, water-soluble, polymer-linked form of retinal was synthesized and tested for its ability to support the growth of vitamin A-deficient noninbred Holtzman rats and to inhibit the proliferation of melanoma cells in culture. Retinal was conjugated to the hydrazide of carboxymethyldextran in the presence of alpha - and beta -cyclodextrins. The aqueous solutions of the product contained retinal 200 to 1000 mu g/ml as opposed to the low water solubility (less than 0.01 mu g/ml) of retinal itself. The retinal-dextran complex, although barely absorbed from the gastrointestinal tract, supported the growth of rats on a vitamin A-deficient diet when given intraperitoneally at 2.3 mu mol retinal equivalent per kg bodyweight. Retinal and the retinal-dextran complex exhibited differential cytotoxicity toward S91 melanoma cells and caused cell lysis at 10 and 500 mu M (retinal residue), respectively. At noncytotoxic doses free retinal and its dextran-linked derivative reduced the cell proliferation rate in a time- and dose-dependent fashion with median inhibitory doses of 1 and 4 mu M (retinal residue), respectively.
KW - RETINOL
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A activity of retinal-dextran complex
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811421931&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Chesson strain of Plasmodium vivax in Aotus monkeys and anopheline mosquitoes.
AU - Collins, W. E.
AU - Warren, McW
AU - Contacos, P. G.
AU - Skinner, J. C.
AU - Richardson, B. B.
AU - Kearse, T. S.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1980///
VL - 66
IS - 3
SP - 488
EP - 497
SN - 0022-3395
AD - Collins, W. E.: Vector Biology and Control Division, Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, USDHEW, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19800577779. Publication Type: Journal Article. Language: English. Number of References: 4 pp. ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - The Chesson strain of Plasmodium vivax was studied in monkeys (Aotus trivirgatus) and parasitaemia in intact and splenectomised animals was similar to that reported for this strain in man. Comparative infectivity studies with mosquitoes fed on infected monkeys indicated that the most susceptible species was Anopheles freeborni Aitken, followed by A. balabacensis balabacensis Baisas, A. culicifacies Giles, A. maculatus Theo., A. atroparvus Van Thiel, A. stephensi List., A. quadrimaculatus Say and A. albimanus Wied., in that order. Transmission by A. maculatus was demonstrated on 2 occasions; the prepatent periods were 30 and 32 days.
KW - disease transmission
KW - infectivity
KW - mosquito nets
KW - parasites
KW - transmission
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles atroparvus
KW - Anopheles culicifacies
KW - Anopheles freeborni
KW - Anopheles maculatus
KW - Anopheles quadrimaculatus
KW - Anopheles stephensi
KW - Aotus trivirgatus
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - insects
KW - Plasmodium vivax
KW - Primates
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Aotus
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Anopheles balabacensis
KW - Anopheles balabacensis balabacensis
KW - Chesson strain
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800577779&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Utilization and interconversion of purines and ribonucleosides in the mosquito Anopheles albimanus Weidemann.
AU - Miller, S.
JO - Comparative Biochemistry and Physiology, B.
JF - Comparative Biochemistry and Physiology, B.
Y1 - 1980///
VL - 66
IS - 3
SP - 517
EP - 522
AD - Miller, S.: Center for Disease Control, Public Health Service, USDHEW, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19800577819. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9027-80-9. Subject Subsets: Medical & Veterinary Entomology
N2 - The salvage pathways of ribonucleotide synthesis in adults of Anopheles albimanus Wied. were established by the incorporation of 8-14 C-labelled purines and ribonucleosides into the RNAs. A comparison of enzymatic activities showed that adenine phosphoribosyltransferase is the most active enzyme in purine nucleotide synthesis. Adenosine is presumably deaminated to inosine. Evidence is presented for the existence of inosine kinase. The data showed low hypoxanthineguanine phosphoribosyltransferase activity. For comparison, the activity of this enzyme was considered in Musca domestica L. The transformation of adenine into guanine is reversible, due to detectable activity found in RNA adenine when radioactive guanine was the precursor. This finding established the presence of guanosine monophosphate reductase. It was concluded that adenine phosphoribosyltransferase is a metabolically important enzyme in mosquito maturation and that inhibitors of the enzyme may have potential value as insect control agents.
KW - adenine phosphoribosyltransferase
KW - enzymes
KW - metabolism
KW - mosquito nets
KW - purines
KW - ribonucleosides
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Musca domestica
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Musca
KW - Muscidae
KW - house fly
KW - kinase (phosphorylating), inosine
KW - mosquitoes
KW - phosphoribosyltransferase, hypoxanthine
KW - purine bases
KW - reductase, guanylate
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Other Control Measures (HH700)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800577819&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on the West Pakistan strain of Plasmodium vivax in Aotus monkeys and anopheline mosquitoes.
AU - Collins, W. E.
AU - Warren, M.
AU - Skinner, J. C.
AU - Richardson, B. B.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1980///
VL - 66
IS - 5
SP - 780
EP - 785
SN - 0022-3395
AD - Collins, W. E.: Vector Biology and Control Division, Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, USDHEW, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810584018. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - When the West Pakistan strain of Plasmodium vivax was established in 17 individuals of Aotus trivirgatus griseimembra, parasitaemia levels were moderate. In animals with prior experience of P. falciparum and a heterologous strain of P. vivax, there was a marked reduction in parasitaemia levels, but the infectivity of Anopheles mosquitoes that fed on these individuals was similar to that of mosquitoes that fed on monkeys with no prior malaria experience. Comparative infectivity studies indicated that this strain in Aotus was most infective to Anopheles freeborni Aitken, followed by A. balabacensis balabacensis Baisas, A. maculatus Theo. and A. culicifacies Giles. A. albimanus Wied. was infected only rarely. The intensity of salivary-gland infections was highest in A. maculatus, followed by A. culicifacies, A. freeborni and A. b. balabacensis. Transmission by bite was obtained once with A. freeborni and once with A. maculatus; the prepatent periods were 20 and 25 days.
KW - disease transmission
KW - experimental infection
KW - infectivity
KW - mosquito nets
KW - parasites
KW - transmission
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles balabacensis
KW - Anopheles culicifacies
KW - Anopheles freeborni
KW - Anopheles maculatus
KW - Aotus trivirgatus
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - insects
KW - Plasmodium vivax
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Aotus
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Anopheles balabacensis
KW - Anopheles balabacensis balabacensis
KW - Aotus trivirgatus griseimembra
KW - experimental transmission
KW - infectivity to mosquito
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584018&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human babesiosis in North America.
AU - Ruebush, T. K., II
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1980///
VL - 74
IS - 2
SP - 149
EP - 152
SN - 0035-9203
AD - Ruebush, T. K., II: Public Health Service, USDHEW, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810584157. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - The author discusses the characteristics and presumed epidemiology of the 21 cases of human babesiosis (caused by tick-born Babesia spp.) that have occurred since 1968 in North America (Mexico, Georgia, California, Massachusetts and New York) [see also preceding abstract, etc.]. Most were caused by B. microti. The chief reservoir of B. microti appeared to be the deer mouse (Peromyscus leucopus) and the meadow vole (Microtus pennsylvanicus); the presumed vector is Ixodes dammini Spielman, Clifford, Piesman & Corwin, which feeds as larvae and nymphs on these rodents and has also been found on domestic animals and man. The white-tailed deer (Odocoileus virginianus) is the chief host of the adult ticks.<new para>ADDITIONAL ABSTRACT:<new para>Since 1968, 21 cases of human babesiasis have been reported from North America, 13 in Massachusetts, 3 in New York, one in Georgia, one in California and 3 in Mexico. The symptoms were usually mild. The organism resembled Babesia microti. The vector is believed to have been Ixodes dammini in many cases. All the patients were more than 48 years old. 30 references are cited.
KW - disease transmission
KW - parasites
KW - reservoirs
KW - transmission
KW - California
KW - Georgia
KW - Massachusetts
KW - Mexico
KW - New York
KW - North America
KW - USA
KW - Acari
KW - Apicomplexa
KW - Babesia microti
KW - Ixodes scapularis
KW - man
KW - Microtus pennsylvanicus
KW - Odocoileus virginianus
KW - Peromyscus leucopus
KW - protozoa
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Babesia
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Microtus
KW - Arvicolinae
KW - Muridae
KW - rodents
KW - Odocoileus
KW - Cervidae
KW - ruminants
KW - Artiodactyla
KW - Peromyscus
KW - Sigmodontinae
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Southeastern States of USA
KW - New England States of USA
KW - Northeastern States of USA
KW - Developing Countries
KW - Latin America
KW - Threshold Countries
KW - Middle Atlantic States of USA
KW - human babesiosis
KW - Ixodes dammini
KW - United States of America
KW - water reservoirs
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584157&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of IHA test for amoebiasis on serum and filter paper specimens.
AU - Mathews, H. M.
AU - Spencer, H. C.
AU - Healy, G. R.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1980///
VL - 74
IS - 3
SP - 404
EP - 405
SN - 0035-9203
AD - Mathews, H. M.: Center for Disease Control, Public Health Service, US Dep. of Health, Education & Welfare, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19800874315. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Protozoology
N2 - One hundred and ten blood samples collected in El Salvador both in tubes (for recovery of serum) and on filter papers were later examined for antibodies to Entamoeba histolytica by the indirect haemagglutination test. There was good correlation between the titres observed, and it is concluded that the filter paper technique is a convenient and reliable method of collecting specimens for serological testing.
KW - IMMUNODIAGNOSIS
KW - parasites
KW - El Salvador
KW - Entamoeba histolytica
KW - man
KW - protozoa
KW - Entamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - diagnosis by IHAT using filter paper specimens
KW - Salvador
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19800874315&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Calcium, phosphorus, iron, iodine, and zinc levels in the "Total Diet".
AU - Harland, B. F.
AU - Johnson, R. D.
AU - Blendermann, E. M.
AU - Prosky, L.
AU - Vanderveen, J. E.
AU - Reed, G. L.
AU - Forbes, A. L.
AU - Roberts, H. R.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1980///
VL - 77
IS - 1
SP - 16
EP - 20
SN - 0002-8223
AD - Harland, B. F.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19801413109. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7440-70-2, 7553-56-2, 7439-89-6, 7723-14-0, 7440-66-6. Subject Subsets: Human Nutrition
N2 - From analysis of food from 20 urban areas of USA in 1974-75, the daily intakes as percentages of the recommended dietary allowance (NAR 40, 1052) were for adults, based on a 2800 kcal intake, for children 2 years old and for infants 6 months old, of calcium 114, 114 and 163, phosphorus 171, 130 and 173, iron 98, 112 and 47, iodine 428, 526 and 878 and zinc 89, 106 and 112.
KW - calcium
KW - iodine
KW - iron
KW - nutrients
KW - phosphorus
KW - zinc
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - daily intake of minerals from US diet
KW - United States of America
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The swallow bug, Oeciacus vicarius Horvath (Hemiptera: Cimicidae), a human household pest.
AU - Eads, R. B.
AU - Francy, D. B.
AU - Smith, G. C.
JO - Proceedings of the Entomological Society of Washington
JF - Proceedings of the Entomological Society of Washington
Y1 - 1980///
VL - 82
IS - 1
SP - 81
EP - 85
SN - 0013-8797
AD - Eads, R. B.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, Department of Health, Education and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19800574635. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - As a result of the identification of bugs reported to have attacked man in houses in rural and urban areas of Colorado and Wyoming in 1978 as Oeciacus vicarius Horv., of which the main host is the cliff swallow (Petrochelidon pyrrhonota), the possibly developing status of this cimicid as a pest of man and measures for its control are discussed. Bites on laboratory staff were locally painful and itched for several days but were not really pathogenic, and none of the persons bitten became either hypersensitised or completely desensitised to subsequent bites. It is concluded that O. vicarius is not dangerous to man unless it acquires a virus affecting man, as it has been shown to acquire 2 viruses of the encephalitis type that were isolated from cliff swallows and sparrows (Passer domesticus). Since P. pyrrhonota is protected by law and neither the birds nor their occupied nests may be destroyed, it is suggested that the nuisance of bugs both to man and to the swallows may be minimised by the destruction of old nests after the migration of the swallows to prevent their use by house sparrows (which can become hosts of O. vicarius and ensure the survival of the bug population throughout the winter) and by spraying the nest attachment sites on houses with an approved residual insecticide; the provision of alternative nesting sites by adaptations to outbuildings not inhabited by man is also recorded from the literature as a helpful means of bug and swallow management.
KW - bites
KW - control
KW - dwellings
KW - insect control
KW - introduced species
KW - pain
KW - pruritus
KW - Colorado
KW - USA
KW - Wyoming
KW - Cimicidae
KW - Hemiptera
KW - Hirundo
KW - Hirundo pyrrhonota
KW - man
KW - Oeciacus vicarius
KW - Passer domesticus
KW - Heteroptera
KW - Hemiptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Hirundo
KW - Hirundinidae
KW - Passeriformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Passer
KW - Ploceidae
KW - Oeciacus
KW - Cimicidae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - itchiness
KW - itching
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Petrochelidon
KW - Petrochelidon pyrrhonota
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Other Control Measures (HH700)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative elution of thyroidal amino acids from a cation-exchange column: analysis of tablet formulations containing dyes.
AU - Rapaka, R. S.
AU - Knight, P. W.
AU - Prasad, V. K.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1980///
VL - 196
IS - 3
SP - 512
EP - 514
SN - 0021-9673
AD - Rapaka, R. S.: Biopharmaceutics Lab., Food and Drug Administration, Bureau of Drugs, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19801412439. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
KW - amino acids
KW - thyroid hormones
KW - estimation of thyroidal amino acids
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermoregulatory ability of female rats during pregnancy and lactation.
AU - Knecht, E. A.
AU - Toraason, M. A.
AU - Wright, G. L.
JO - American Journal of Physiology
JF - American Journal of Physiology
Y1 - 1980///
VL - 239
IS - 5
SP - R470
EP - R475
SN - 0002-9513
AD - Knecht, E. A.: US Dep. Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Inst. Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19811417577. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - Thermoregulatory ability of female rats was studied before pregnancy, during gestation and during lactation. Thermoregulatory pattern, colonic temperature, evaporative water loss, and survival time were monitored during terminal heating (39.5 deg C) designed to allow prolonged survival (3 to 4 h) with a sustained thermoregulatory effort. Results showed decreased thermoregulatory ability in lactating dams, with evidence suggesting thermoregulatory impairment during late gestation. Lactating dams displayed a type III thermoregulatory pattern, and established a rate of evaporative water loss effective for thermostasis at an increased colonic temperature. Survival time was significantly less than that of nonreproducing females. In contrast, adaptation to heat tended to increase the survival time of lactating dams. It was concluded that the reduction in thermoregulatory ability in lactating dams was related to their inability to maintain a rate of evaporative water loss effective for thermostasis at an increased colonic temperature.
KW - lactation
KW - pregnancy
KW - thermoregulation
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - heat regulation
KW - heat regulation in pregnancy and lactation
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811417577&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relapses in primate malaria: discovery of two populations of exoerythrocytic stages. Preliminary note.
AU - Krotoski, W. A.
AU - Krotoski, D. M.
AU - Garnham, P. C. C.
AU - Bray, R. S.
AU - Killick-Kendrick, R.
AU - Draper, C. C.
AU - Targett, G. A. T.
AU - Guy, M. W.
JO - British Medical Journal
JF - British Medical Journal
Y1 - 1980///
VL - 280
IS - 6208
SP - 153
EP - 154
AD - Krotoski, W. A.: Tropical Infectious Disease Res. Program, US Public Health Service Hospital, New Orleans, LA 70118, USA.
N1 - Accession Number: 19800865820. Publication Type: Journal Article. Language: English. Subject Subsets: Protozoology
N2 - Twelve million sporozoites of Plasmodium cynomolgi bastianellii were injected intravenously into a rhesus monkey and biopsies of the liver were taken at intervals up to 102 days later. The monkey was killed after 105 days. Sections taken on the 7th day showed the usual large schizonts 35 mu m in diameter and also very small parasites in the parenchymatous cells. These were first identified by immunofluorescence. They measured 2.9 to 5.5 mu m in diameter. Each contained a single reddish-purple nucleus (Giemsa stain) surrounded by clear bluish cytoplasm and a fine limiting membrane. A 50-day biopsy specimen contained similar small parasites measuring 5.7 to 7.0 mu m in diameter. It is postulated that these small parasites develop from a special kind of sporozoite and that they are responsible for the relapses which may occur with some species of malaria parasites.
KW - life history
KW - parasites
KW - Macaca mulatta
KW - Plasmodium cynomolgi
KW - Primates
KW - protozoa
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Plasmodium cynomolgi
KW - new exoerythrocytic stage
KW - Plasmodium cynomolgi bastianellii
KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Frequency of relapse and primaquine resistance in Southeast Asian Vivax malaria.
AU - Krotoski, W. A.
T2 - New England Journal of Medicine
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1980///
VL - 303
IS - 10
SP - 587
EP - 587
SN - 0028-4793
AD - Krotoski, W. A.: US Public Health Service Hosp., New Orleans, LA 70118, USA.
N1 - Accession Number: 19800878769. Publication Type: Correspondence. Language: English. Number of References: 11 ref. Registry Number: 63-45-6, 90-34-6. Subject Subsets: Protozoology
N2 - Two little-appreciated features of Southeast Asian strains of Plasmodium vivax are noted for the attention of physicians in the USA who are either treating Indochinese refugees with P. vivax malaria, or who are evaluating the possibility of transmission within the USA. Firstly, these strains of P. vivax can relapse more frequently in a given period of time than can strains acquired elsewhere; secondly, these strains also have some exoerythrocytic stages that are more resistant to primaquine than are their geographically temperate counterparts. The choice of higher-dose primaquine regimens, especially with regard to the G6PD status of the patient, is briefly discussed.
KW - DRUG RESISTANCE
KW - DRUG THERAPY
KW - drugs
KW - parasites
KW - primaquine
KW - resistance
KW - South East Asia
KW - man
KW - Plasmodium vivax
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Asia
KW - Asia, Southeast
KW - chemotherapy
KW - medicines
KW - pharmaceuticals
KW - Southeast Asia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Zinc-induced anemia in young Japanese quail ameliorated by supplemental copper and iron.
AU - Hamilton, R. P.
AU - Fox, M. R. S.
AU - Tao, S. H.
AU - Fry, B. E., Jr.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1981///
VL - 1
IS - 6
SP - 589
EP - 599
SN - 0271-5317
AD - Hamilton, R. P.: Division of Nutrition, Bureau of Foods, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19821434772. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 7440-50-8, 7439-89-6, 7440-66-6. Subject Subsets: Human Nutrition
N2 - Groups of 10 Japanese quail (Coturnix coturnix japonica) got purified basal diet adequate in all nutrients as far as requirements were known, including zinc 20, iron 100, manganese 2.5, copper 1.5 and magnesium 300 mg/kg diet. In the 1st trial the quail were fed for 7 days on basal diet alone or with Zn 250 mg/kg added as carbonate. The other trials were for 14 days. In the 2nd trial, quail got basal diet alone or with Zn 250 or 500 mg/kg added. In the 3rd they got it alone or with Zn 500 mg/kg added, or with Zn 500 and Fe 100, Cu 1.5 or Mg 100 mg/kg, or Fe and Cu, Fe and Mg, Cu and Mg, or Fe, Cu and Mg, total 9 diets. In the 4th they got it alone or with Zn 500 mg/kg added, or with Zn 500 and Fe 100 or 200, or Cu 1.5 or 5, or either dose of Fe with either of Cu, total 10 diets. In the 5th they got basal diet alone or with Zn 500 mg/kg added, each alone or with Fe 100, Cu 1.5 mg/kg or both added, total 8 diets. In the 6th trial they got basal diet with Zn none or 250 mg/kg added, with the basal amount of other minerals or with Fe decreased to 35 or Cu to 1.1 mg/kg diet, or both, total 8 diets. There was no significant mortality in any group. In the first 2 trials, bodyweight decreased significantly by 14 days with Zn 500 mg/kg added, but not by 7 days or with Zn 250 mg/kg, below that on basal diet. Hb decreased by 7 days with Zn 500 or by 13 days with Zn 250 or 500 mg/kg added. Liver was analysed at the end of each trial. In the 1st trial, Zn 250 mg/kg increased Zn and decreased Fe, Mn and Cu; in the 2nd trial Zn 250 mg/kg had the same effect on Zn and Cu; Zn 500 mg/kg had the same effect on Zn, Fe, Mn and Cu as did Zn in the 1st trial. There was no significant effect on Mg in either trial. In the 3rd and 4th trials, bodyweight at 14 days was depressed by the added Zn and generally not depressed when Cu as well as Zn was added. White feather score increased with Zn except when Cu was added also. In the 3rd trial, Zn decreased Hb except when Fe and Cu together were added. In the 4th trial, Zn decreased Hb. With Fe 200 mg/kg added also, Hb remained depressed. With Fe 100 given with Cu 5 or 1.5, or with Fe 200 given with Cu 5 mg/kg, Hb remained normal but with other treatments it was not significantly different from normal or depressed Hb. In the 5th trial, with no extra Zn there was no effect of extra Fe, Cu or both on bodyweight, white feather score or Hb except that Fe increased bodyweight slightly. With extra Zn, Cu prevented the decrease in bodyweight and decreased the white feather score; Cu with Fe prevented the decrease in Hb. Supplements of Fe or Cu increased Fe or Cu concentration in liver; without excess Zn in diet there was no imbalance or interaction between Fe and Cu. Extra Zn in diet increased Zn in liver, except with Cu added also. Zn in diet depressed Fe in liver, which was partly alleviated with added Fe. Cu supplement in diet returned Cu to normal in liver. In the 6th diet, Zn decreased bodyweight on diets deficient in Cu. All groups deprived of Cu or given extra Zn had white feather, especially the group with both those factors. The slight Cu deficiency did not affect Hb except with excess Zn and adequate Fe in diet. Results are discussed, with the literature. It was difficult to know the implications of animal data to man, but the results supported the need for further study of the effect of Zn on the Fe and Cu status of man.
KW - anaemia
KW - copper
KW - iron
KW - zinc
KW - amelioration by copper and iron of zinc-induced anaemia (Japanese quail)
KW - anemia
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Treatment of scabies and pediculosis with lindane preparations: an evaluation.
AU - Shacter, B.
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
Y1 - 1981///
VL - 5
IS - 5
SP - 517
EP - 527
SN - 0190-9622
AD - Shacter, B.: Public Health Service, Israel Ministry of Health, Jerusalem, Israel.
N1 - Accession Number: 19830599920. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 58-89-9, 121-75-5, 608-73-1. Subject Subsets: Medical & Veterinary Entomology
N2 - The author discusses the risks and benefits involved in the use of lindane preparations for the treatment of human scabies (caused by Sarcoptes scabiei (L.) (scabiei hominis Raspail)) and pediculosis (caused by Pediculus capitis Deg. (humanus var. capitis)). Although lindane per se is moderately toxic to man, capable of inducing neurotoxic and haemotoxic effects, there is little evidence that the preparations used in the treatment of scabies and pediculosis give rise to toxic symptoms when applied according to directions. It is concluded that the benefits obtained in the use of lindane outweigh risks involved in its use. Comparison with other preparations available for the control of scabies and pediculosis indicates that lindane is probably the most effective against scabies, although it also shows the greatest toxic potential. Malathion and pyrethrin preparations seem equally effective against pediculosis. Suggestions for even safer use of lindane are discussed.
KW - acaricides
KW - chemical control
KW - control
KW - HCH
KW - insecticides
KW - lindane
KW - malathion
KW - pest control
KW - pyrethrins
KW - toxicity
KW - Israel
KW - Acari
KW - Anoplura
KW - man
KW - Pediculus capitis
KW - Sarcoptes scabiei
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Sarcoptes
KW - Sarcoptidae
KW - Astigmata
KW - mites
KW - Acari
KW - Developed Countries
KW - Mediterranean Region
KW - Middle East
KW - West Asia
KW - Asia
KW - benzene hexachloride
KW - BHC
KW - head louse
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Considerations for a new food guide.
AU - Pennington, J. A. T.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1981///
VL - 13
IS - 2
SP - 53
EP - 55
SN - 0022-3182
AD - Pennington, J. A. T.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19841451487. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The example of a possible new food guide for USA is not as simple as the Four Food Groups or sufficiently detailed to meet all contingencies. It is flexible, encourages the consumption of foods with high nutrient density and discourages consumption of foods with constituents thought to be detrimental to health. Its appearance may attract attention and is simple enough to be understood by children. Food groups are represented as a triangle, with the apex downward and divided horizontally into 4 sections of equal depth. The uppermost, therefore the largest, section is of foods for liberal consumption; fruit and vegetables, legumes and grain. The next, for moderate consumption, is of low-fat milk, yoghurt and cheese; lean meat, fish and poultry. The 3rd, for very moderate consumption, is of whole milk and cheese, nuts, eggs and fatty meats, game and sausage. The apical and smallest section, for sparse consumption, is of luxury foods such as desserts, sweets, fats and alcohol. A table shows for each food group several examples of portion sizes and number of servings suggested for daily intake by children or by adolescents and adults.
KW - Nutrition education
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841451487&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reasons for diabetic diet noncompliance among Cherokee Indians.
AU - Broussard, B. A.
AU - Bass, M. A.
AU - Jackson, M. Y.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1981///
VL - 14
IS - 2
SP - 56
EP - 57
SN - 0022-3182
AD - Broussard, B. A.: Indian Health Service, 1101 Kermit Drive, Suite 810, Nashville, Tenn. 37217, USA.
N1 - Accession Number: 19821439541. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
KW - diabetes
KW - diet treatment
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - diet prescription
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821439541&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Moderate amounts of alcoholic beverages and clinical nutrition.
AU - McDonald, J.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1981///
VL - 14
IS - 2
SP - 58
EP - 60
SN - 0022-3182
AD - McDonald, J.: US Public Health Service Hospital, San Francisco, Calif., USA.
N1 - Accession Number: 19821439542. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition
KW - alcoholic beverages
KW - hospital diets
KW - reviews
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diets in hospital
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821439542&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis.
AU - Kuno, G.
JO - In Vitro
JF - In Vitro
Y1 - 1981///
VL - 17
IS - 11
SP - 1011
EP - 1015
SN - 0073-5655
AD - Kuno, G.: San Juan Laboratories, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, GPO Box 4532, San Juan, Puerto Rico.
N1 - Accession Number: 19830501599. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The replication of 7 arthropod-borne viruses was studied in a cell line (TRA-171) derived from the non-haematophagous mosquito Toxorhynchites amboinensis (Doleschall). Four serotypes of laboratory-adapted dengue viruses and 3 serotypes of unadapted dengue viruses replicated in the cell line, inducing syncytia. The sensitivity of TRA-171 cells to dengue virus infection was comparable to that of cells of Aedes albopictus (Skuse) or A. pseudoscutellaris (Theo.). Yellow fever, St. Louis encephalitis and vesicular stomatitis viruses also replicated. All 4 serotypes of dengue viruses could be plaque assayed with TRA-171 cell cultures.
KW - cell cultures
KW - hosts
KW - mosquito nets
KW - replication
KW - vesicular stomatitis viruses
KW - Aedes albopictus
KW - Aedes pseudoscutellaris
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Toxorhynchites amboinensis
KW - yellow fever virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Toxorhynchites
KW - Vesiculovirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - vesicular stomatitis virus
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830501599&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A method for isolating continuous cell lines from Toxorhynchites amboinensis (Diptera: Culicidae).
AU - Kuno, G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1981///
VL - 18
IS - 2
SP - 140
EP - 144
SN - 0022-2585
AD - Kuno, G.: San Juan Laboratories, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Puerto Rico 00936, USA.
N1 - Accession Number: 19810585983. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Minced larval tissue fragments and mechanically damaged but living whole larvae of Toxorhynchites amboinensis (Doleschall) were compared for initiating continuous cell lines. No cell line was obtained from completely minced larval tissue fragments, although patches of cells that adhered to the glass walls of the test-tube often replicated for 3-8 weeks. Over 20 continuous cell lines were isolated however from mechanically damaged but living larvae. The presence of at least 5 damaged larvae in tubes containing cells attached to the glass walls during the first 8 weeks in primary culture was found to be important for isolating continuous cell lines, and cell lines were isolated faster in tubes that contained more than 5 damaged larvae.
KW - cell cultures
KW - cell lines
KW - mosquito nets
KW - techniques
KW - Culicidae
KW - Diptera
KW - Toxorhynchites amboinensis
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Toxorhynchites
KW - Culicidae
KW - establishing
KW - establishing mosquito cell lines
KW - mosquitoes
KW - Techniques and Methodology (ZZ900)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585983&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Light-trap response and the DV/D ratio in the Culex pipiens complex (Diptera: Culicidae).
AU - Wilton, D. P.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1981///
VL - 18
IS - 4
SP - 284
EP - 288
SN - 0022-2585
AD - Wilton, D. P.: Vector Biology and Control Division, Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810587362. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The responses of Culex pipiens pipiens L. from Lyons, Illinois, C. quinquefasciatus Say (pipiens quinquefasciatus) from New Orleans, Louisiana, and their hybrids were compared in a series of short experiments in walk-in test chambers. C. p. pipiens showed the greatest response to light and C. quinquefasciatus the least, while hybrid responses occupied an intermediate position; this was true of both sexes, although more females in general were caught than males. Analysis of the DV/V ratios of trapped and untrapped hybrid males showed that the males attracted to the light-trap had wings significantly more closely remsembling those of C. p. pipiens than those of C. quinquefasciatus, whereas trapped and untrapped males of either of the parent subspecies could not be distinguished on the basis of the DV/D ratio.
KW - effects
KW - light
KW - mosquito nets
KW - responses
KW - Culex pipiens pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Diptera
KW - Culex pipiens
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810587362&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diapause termination, gonoactivity, and differentiation of host-seeking behavior from blood-feeding behavior in hibernating Culex tarsalis (Diptera: Culicidae).
AU - Mitchell, C. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1981///
VL - 18
IS - 5
SP - 386
EP - 394
SN - 0022-2585
AD - Mitchell, C. J.: Vector-Borne Diseases Division, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19820589473. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 40596-69-8. Subject Subsets: Medical & Veterinary Entomology
N2 - Diapausing individuals of Culex tarsalis Coq. were collected from mine tunnels in Boulder County, Colorado, in late September and early October 1980 and studied in the laboratory. Exposure to a long photophase (LD 15:9) resulted in diapause termination in virtually all mosquitoes maintained at 25 deg C for 7 days, but this temperature alone did not terminate diapause in many females that were kept at typical autumn daylengths. Diapause was terminated in C. tarsalis by topical application of methoprene, which suggested that the physiological pathway for diapause termination involved juvenile-hormone secretion by reactivated corpora allata. Host-seeking and blood-feeding were shown to represent distinct phases in the biting cycle of C. tarsalis, and these were differentiated in diapausing females by varying the size of the feeding chamber. Diapausing females could be induced to take a blood-meal only when the host-seeking phase was bypassed by placing the females close to a potential host. Gonotrophic dissociation (failure of ovarian follicles to mature beyond the resting stage following a full blood-meal) occurred in a significant proportion of females only if these females were in diapause when fed and were afterwards maintained at 15 deg C and under short-day conditions during the period of blood-meal digestion. The demonstration that gonotrophic dissociation could occur under experimental conditions probably has no relation to what occurs in nature. Even in warm Indian-summer conditions, the typical short daylengths of autumn suppress host-seeking behaviour in diapausing populations, and in nature host-seeking is a prerequisite for blood-feeding.
KW - behaviour
KW - diapause
KW - feeding behaviour
KW - methoprene
KW - mosquito nets
KW - Colorado
KW - USA
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - behavior
KW - feeding behavior
KW - host-seeking
KW - mines
KW - mosquitoes
KW - terminating diapause
KW - United States of America
KW - Animal Behaviour (LL300)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820589473&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Subchronic effects of guar gum in rats.
AU - Graham, S. L.
AU - Arnold, A.
AU - Kasza, L.
AU - Ruffin, G. E.
AU - Jackson, R. C.
AU - Watkins, T. L.
AU - Graham, C. H.
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
Y1 - 1981///
VL - 19
IS - 3
SP - 287
EP - 290
AD - Graham, S. L.: Bureau of Foods, Food and Drug Administration, Dep. Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19811426743. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 9000-30-0. Subject Subsets: Human Nutrition
N2 - Male and female Osborne-Mendel rats, about 4 weeks old, were given guar gum for 91 days at 0, 1.0, 2.0, 4.0, 7.5 or 15.0% diet. Bodyweights, organ weights, haematology, clinical chemistry and histology were the criteria studied. Guar gum significantly reduced bodyweights in females of all the treated groups and in males on 7.5 and 15%. Utilization of the gum was poor and, at 15%, there was some reduction in bone marrow cellularity. Serum glucose values and kidney weights were the only other indices showing dose-related effects.
KW - effects
KW - guar gum
KW - metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811426743&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological and biochemical evaluation of commercial powdered protein products.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1981///
VL - 24
IS - 3
SP - 499
EP - 511
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Dep. Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19821432261. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Of the examined products from drug and health food stores 8 had soya protein, 6 milk protein, 2 protein hydrolysates, 1 dried meat stock and 1 had brewer's yeast as main ingredients. The products had nitrogen 2.8 to 15.3, moisture 1.5 to 7.6, ash 0.7 to 12.6 and fat 0.7 to 13.0%. Protein supplied more than 50% of total energy in 16 products and 19 and 37% in the other two. Protein efficiency ratios in studies with rats were 23 to 100% of the value for casein. Products grouped together by main ingredient did not always evoke similar food intake and growth response. Enlarged organs, fat accumulation in liver, changes in vitamin A storage in liver and decreased plasma protein occurred in rats given some products. Results indicated that generalizations based on label claims cannot be made.
KW - nutritive value
KW - protein foods
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biological value of powdered protein products
KW - nutritional value
KW - quality for nutrition
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821432261&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioavailability of lead in oysters fed to young Japanese quail.
AU - Stone, C. L.
AU - Fox, M. R. S.
AU - Hogye, K. S.
JO - Environmental Research
JF - Environmental Research
Y1 - 1981///
VL - 26
IS - 2
SP - 409
EP - 421
AD - Stone, C. L.: Division of Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19821433530. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Day-old Japanese quail were given purified diets with three concentrations of lead added as lead acetate, freeze-dried oyster which had been given Pb, or lead acetate plus freeze-dried control oyster for 2 weeks. Giving Pb from any source had little or no effect on bodyweight, haemoglobin, haematocrit or percentage ash in the tibia. The concentration of Pb in tibia at each concentration of dietary Pb for each type of diet was different from those for all other amounts of dietary Pb. Slope-ratio analysis of the data showed that Pb intrinsically incorporated into oyster meat was 69 to 75% as bioavailable as Pb in lead acetate at dietary Pb between 25 and 100 mg/kg. The combinations of control oyster meat with lead acetate and lead acetate with amounts of copper and zinc equal to those in oyster meat gave responses similar to those of the oyster groups given Pb. Although the results showed lower bioavailability of Pb in oyster meat as compared with lead acetate, the intercept of the lines at dietary Pb 25 mg/kg suggests that the relative bioavailability may be reversed at lower amounts of Pb intake.
KW - lead
KW - oysters
KW - MOLLUSCA
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - availability of lead from oysters (Japanese quail)
KW - molluscs
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821433530&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of liquid protein products for amino acids, carbohydrates, and peptides.
AU - Grundel, E.
AU - O'Dell, R. G.
AU - Pirisino, J.
AU - Prosky, L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1981///
VL - 29
IS - 1
SP - 187
EP - 188
SN - 0021-8561
AD - Grundel, E.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19811422293. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 56-81-5, 50-70-4. Subject Subsets: Human Nutrition
N2 - A table gives the amino acid composition of 21 commercial liquid protein products, all derived from partly hydrolysed collagen and gelatin and used to treat obesity. There were large variations among products and between claimed and actual values. Glycerol in 6 products was 3 to 20 and sorbitol in 9 products was 1 to 25 g/100 ml, equivalent at most to 23.6 and 30 kcal/serving, although according to the labels only protein supplied energy.
KW - amino acids
KW - carbohydrates
KW - glycerol
KW - obesity
KW - peptides
KW - protein hydrolysates
KW - sorbitol
KW - analysis of liquid protein products used to treat obesity for amino acids, carbohydrates and peptides
KW - fatness
KW - glycerin
KW - glycerine
KW - hydrolysed proteins
KW - liquid protein
KW - saccharides
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811422293&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The 48-hour exoerythrocytic stage of Plasmodium cynomolgi bastianellii.
AU - Krotoski, W. A.
AU - Collins, W. E.
AU - Broderson, J. R.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 1
SP - 31
EP - 37
SN - 0002-9637
AD - Krotoski, W. A.: Clinical Res. Dep., US Public Health Service Hos., New Orleans, LA 70118, USA.
N1 - Accession Number: 19810884282. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Protozoology
N2 - The 48-hour exoerythrocytic stage of Plasmodium cynomolgi bastianellii was detected by a specific indirect immunofluorescence technique (IFA) applied to hepatic tissue of a Macaca mulatta monkey. The 48-hour forms appeared as round-to-slightly-oval bodies of average mean diameter 3.0 mu m (9 parasites) and lying within the cytoplasm of individual hepatic parenchymal cells; each possessed one to 3 non-fluorescent nuclei or nuclear sections (mean 1.6) within the brightly fluorescent parasitic cytoplasm. In contrast, 72-hour parasites (6) had an average mean diameter of 4.0 mu m and a mean of 2.2 nuclei. Restaining of IFA preparations with the Giemsa-colophonium method confirmed the plasmodial nature of fluorescent forms, despite some modification of staining characteristics produced by the prolonged exposure of sections to the aqueous phase of the IFA procedure. Exoerythrocytic forms could not be detected in biopsies obtained 24 hours following sporozoite inoculation. [AS]
KW - life history
KW - parasites
KW - Macaca mulatta
KW - Plasmodium cynomolgi
KW - Primates
KW - protozoa
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Plasmodium cynomolgi
KW - 48-hour exoerythrocytic form
KW - Plasmodium cynomolgi bastianellii
KW - Medical and Veterinary Protozoology Records (TT200) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810884282&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viruses isolated from Aedeomyia squamipennis mosquitoes collected in Panama, Ecuador, and Argentina: establishment of the Gamboa serogroup.
AU - Calisher, C. H.
AU - Lazuick, J. S.
AU - Justines, G.
AU - Francy, D. B.
AU - Monath, T. P.
AU - Gutierrez V., E.
AU - Sabattini, M. S.
AU - Bowen, G. S.
AU - Jakob, W. L.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 1
SP - 219
EP - 223
SN - 0002-9637
AD - Calisher, C. H.: Vector-Bourne Diseases Division, Bureau of Laboratories, Center for Disease Control, US Department of Health and Human Services, P O Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810582557. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Twenty-four virus strains were isolated from females of Aedeomyia squamipennis (Lynch Arrib.) collected in Ecuador. One additional strain each was isolated from this species from Panama and Argentina. All 26 isolated were shown to be related serologically to prototype Gamboa virus, originally isolated from A. squamipennis collected in Panama. Antigenic comparisons of 8 strains, including prototype Gamboa virus, indicated the existence of 4 distinct viruses. Neutralisation tests with sera from a vareity of mammals and birds from Argentina provided further evidence that Gamboa serogroup viruses are transmitted between A. squamipennis and birds.
KW - mosquito nets
KW - Argentina
KW - Ecuador
KW - Panama
KW - Aedeomyia squamipennis
KW - Culicidae
KW - Diptera
KW - viruses
KW - Aedeomyia
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Andean Group
KW - Central America
KW - Gamboa viruses
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810582557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental infection of ectoparasitic arthropods with Rickettsia prowazekii (GvF-16 strain) and transmission to flying squirrels.
AU - Bozeman, F. M.
AU - Sonenshine, D. E.
AU - Williams, M. S.
AU - Chadwick, D. P.
AU - Lauer, D. M.
AU - Elisberg, B. L.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 1
SP - 253
EP - 263
SN - 0002-9637
AD - Bozeman, F. M.: Bureau of Biologics, US Public Health Service, 8800 Rockville Pike, Bethesda, Maryland 20205, USA.
N1 - Accession Number: 19810582560. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Epizootiological studies in Florida and Virginia during the past few years have shown the existence of widespread natural infection of the southern flying squirrel (Glaucomys volans) with epidemic typhus rickettsiae (Rickettsia prowazekii). The ecological findings strongly implicated transmission of the aetiological agent by an arthropod vector. Studies were conducted under controlled laboratory conditions to determine whether ectoparasites naturally associated with flying squirrels (Orchopeas howardii (Baker), Neohaematopinus sciuropteri (Osb.), Haemogamasus reidi Ewing, Androlaelaps fahrenholzi (Berl.) and Dermacentor variabilis (Say) were capable of acquiring, maintaining and transmitting the infection. Also studied were Ctenocephalides felis (Bch.), Xenopsylla cheopis (Roths.) and Pediculus humanus L. (humanus corporis Deg.). Flying squirrels inoculated with the GvF-16 strain of R. prowazekii circulated rickettsiae in their blood for 2-3 weeks, thus providing ample opportunity for arthropods feeding on them to become infected. The results with D. variabilis indicated that the rickettsiae did not consistently survive in this tick and were not transmitted to the eggs of adult females that had been infected subcuticularly. Mites (H. reidi and A. fahrenholzi) became infected by feeding on infectious blood but failed to sustain the infection. Also, mites fed on an infected flying squirrel did not transmit the infection to a grey squirrel. The 3 species of fleas readily became infected by feeding on a rickettsaemic host or on infectious blood through membranes, but failed to transmit the infection to susceptible flying squirrels. In the studies with flying squirrel lice (N. sciuropteri), however, transmission of epidemic typhus from infected to uninfected flying squirrels was demonstrated. Infection of P. humanus with the GvF-16 flying squirrel strain of R. prowazekii was similar to that previously observed with classical human strains, viz., multiplication of the rickettsiae and excretion in the faeces.
KW - disease transmission
KW - replication
KW - transmission
KW - Acari
KW - Androlaelaps fahrenholzi
KW - Ctenocephalides felis
KW - Dermacentor variabilis
KW - Neohaematopinus
KW - Neohaematopinus sciuropteri
KW - Orchopeas howardii
KW - Pediculus humanus
KW - Rickettsia prowazekii
KW - viruses
KW - Xenopsylla cheopis
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Androlaelaps
KW - Laelapidae
KW - Mesostigmata
KW - mites
KW - Acari
KW - Ctenocephalides
KW - Pulicidae
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Orchopeas
KW - Ceratophyllidae
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Xenopsylla
KW - Haemogamasus
KW - Polyplacidae
KW - Neohaematopinus
KW - bacterium
KW - body louse
KW - cat flea
KW - Haemogamasus reidi
KW - Microtabiotes
KW - Oriental rat flea
KW - sciuropteri, Neohaematopinus
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810582560&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental transmission of Rocio virus by mosquitoes.
AU - Mitchell, C. J.
AU - Monath, T. P.
AU - Cropp, C. B.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 2
SP - 465
EP - 472
SN - 0002-9637
AD - Mitchell, C. J.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810584476. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Rocio encephalitis is an epidemic flaviviral infection of man first described in Sao Paulo State, Brazil, in 1975. The virus has been isolated from arthropods (Psorophora ferox (Humb.)) collected in nature only once, and the ecology of the viral transmission cycle remains largely unknown. Rocio virus produces high level viraemias (106.0 to 108.0 Vero cell plaque-forming units (PRU)/ml 48-72 h after infection) in young chicks following subcutaneous inoculation of virus or the bite of a single infected mosquito. The susceptibility of a variety of mosquito species and strains to infection per os was evaluated, virus infection and transmission rates measured, the virus content of infected mosquitoes determined, and information on the growth pattern of Rocio virus in some of the species and strains obtained. On the basis of these data, the mosquitoes tested were classified according to vector potential by assigning them to one of 3 categories. Culex tarsalis Coq. from Arizona and C. pipiens pipiens L. from Illinois were relatively efficient experimental vectors. Both species were readily infected by feeding on infected chicks, and high proportions (92 and 71%, respectively) were able to transmit virus on the 20th day of extrinsic incubation. Subspecies of C. pipiens from Tennessee and C. quinquefasciatus Say (pipiens quinquefasciatus) from Argentina were moderately efficient experimental vectors. Both strains were readily infected (94 to 98%), but transmission rates were low (36 and 23%, respectively). P. ferox, and C. nigripalpus Theo. from Louisiana and C. taeniopus D. & K. (opisthopus Komp) from Florida were relatively inefficient experimental vectors. Either infection rates were low or virus did not grow to high titre in those individuals that became infected, or both. These studies provide support for the hypothesis that Rocio virus is a mosquito-borne arbovirus and illustrate the potential for transmission of the virus by 2 prevalent species of Culex, should the agent be introduced into North America. The role of P. ferox as a natural vector in Brazil appears less likely on the basis of our findings, but there is a need to investigate the vector efficiency of Brazilian strains of this species.
KW - disease transmission
KW - mosquito nets
KW - transmission
KW - Culex nigripalpus
KW - Culex pipiens
KW - Culex pipiens pipiens
KW - Culex quinquefasciatus
KW - Culex taeniopus
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Psorophora ferox
KW - Rocio virus
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex pipiens
KW - Psorophora
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584476&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The ecology of Colorado tick fever in Rocky Mountain National Park in 1974. I. Objectives, study design, and summary of principal findings.
AU - McLean, R. G.
AU - Francy, D. B.
AU - Bowen, G. S.
AU - Bailey, R. E.
AU - Calisher, C. H.
AU - Barnes, A. M.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 2
SP - 483
EP - 489
SN - 0002-9637
AD - McLean, R. G.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Department of Health, Education and Welfare, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810584477. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2 - The ecology of Colorado tick fever was investigated in the Rocky Mountain National Park in 1974. Study sites and sampling methods were selected for measuring the effect of various ecological parameters on virus activity. The important rodent and tick species for virus maintenance, and the habitats that support the hosts, vectors, and the virus were identified [see also next abstract].
KW - disease vectors
KW - ecology
KW - Epidemiology
KW - hosts
KW - Vectors
KW - Colorado
KW - USA
KW - Acari
KW - Colorado tick fever virus
KW - Dermacentor andersoni
KW - Ixodes
KW - rodents
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - mammals
KW - vertebrates
KW - Chordata
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584477&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The ecology of Colorado tick fever in Rocky Mountain National Park in 1974. II. Infection in small mammals.
AU - Bowen, G. S.
AU - McLean, R. G.
AU - Shriner, R. B.
AU - Francy, D. B.
AU - Pokorny, K. S.
AU - Trimble, J. M.
AU - Bolin, R. A.
AU - Barnes, A. M.
AU - Calisher, C. H.
AU - Muth, D. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 2
SP - 490
EP - 496
SN - 0002-9637
AD - Bowen, G. S.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, Department of Health, Education, and Welfare, P O Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810584478. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2 - Field studies of Colorado tick fever in small mammals in Rocky Mountain National Park in 1974 [see also preceding abstract] established that Eutamias minimus and Spermophilus lateralis were the most important hosts for the virus and were the source of virus for immature stages of the tick vector, Dermacentor andersoni Stiles. Other mammals (Peromyscus maniculatus, S. richardsonii, E. umbrinus) were secondary hosts. The intensity of viral activity in rodents varied greatly from locality to locality. Highest rodent infection rates were found to occur in the Moraine Park area. Lowest infection rates occurred above 3290 m in altitude at Rainbow Curve and on the tundra. The prevalence of infection in rodents was constant from April to July (5-6% of animals captured being viraemic) and then declined to 1.7-2.5% in August and September coincident with a decline in infestation by nymphal ticks. Many animals were captured which were simultaneously viraemic and antibody-positive; under field conditions, neutralising antibody sero-conversion does not always occur.
KW - Epidemiology
KW - hosts
KW - small mammals
KW - Wild animals
KW - Colorado
KW - USA
KW - Acari
KW - Colorado tick fever virus
KW - Dermacentor andersoni
KW - Peromyscus maniculatus
KW - rodents
KW - Spermophilus elegans
KW - Spermophilus lateralis
KW - Spermophilus richardsonii
KW - squirrels
KW - viruses
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Peromyscus
KW - Sigmodontinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Spermophilus
KW - Sciuridae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Eutamias minimus
KW - Eutamias umbrinus
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810584478&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectivity of a strain of Plasmodium falciparum from Hainan, People's Republic of China, to different anophelines.
AU - Collins, W. E.
AU - Nguyen-Dinh, P.
AU - Skinner, J. C.
AU - Sutton, B. B.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 3
SP - 538
EP - 540
SN - 0002-9637
AD - Collins, W. E.: Vector Biology and Control Division, Bureau of Tropical Diseases, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810585671. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A strain of Plasmodium falciparum from Hainan Island, China, was established in monkeys (Aotus trivirgatus griseimembra), and different anopheline mosquitoes were tested for their susceptibility to infection. Anopheles freeborni Aitken were the most susceptible followed by A. dirus Peyton & Harrison, A. stephensi List., A. maculatus Theo., A. culicifacies Giles and 2 strains of A. gambiae Giles.
KW - infectivity
KW - mosquito nets
KW - Anopheles
KW - Anopheles culicifacies
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles maculatus
KW - Anopheles stephensi
KW - Aotus trivirgatus
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - Plasmodium falciparum
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aotus
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585671&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transovarial transmission of St. Louis encephalitis virus by Culex pipiens complex mosquitoes.
AU - Francy, D. B.
AU - Rush, W. A.
AU - Montoya, M.
AU - Inglish, D. S.
AU - Bolin, R. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 3
SP - 699
EP - 705
SN - 0002-9637
AD - Francy, D. B.: Vector-Borne Diseases Division, Center for Infectious Diseases, US Department of Health and Human Services, P O Box 2987, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19810585675. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Experiments were conducted to determine whether transovarial transmission of St. Louis encephalitis (SLE) virus occurs in mosquitoes of the complex of Culex pipiens L., the principal vectors of SLE virus in the central-eastern USA. In 1978, field-collected mosquitoes from Memphis, Tennessee and McLeansboro, Illinois, were used; during 1979, colonised mosquitoes from Chicago, Illinois and Memphis, Tennessee, were used. Mosquitoes were infected by feeding on viraemic chicks inoculated with an SLE virus strain isolated from C. pipiens complex mosquitoes collected from Memphis, Tennessee, in 1976. During the 1979 experiments, progeny larval and adult mosquitoes were held at 2 temperatures, 18 and 25 deg C. Progeny were tested for virus by plaque assay in duck embryo cell cultures and by inoculation of C6/36 cells of Aedes albopictus (Skuse) and examination by immunofluorescence. In 1978, most of the progeny tested were from the first ovarian cycle, and a single occurrence of transovarial transmission was documented. In 1979, a single transovarial transmission occurred from 46 856 progeny in the first ovarian cycle, whereas 7 of 9234 progeny of the second ovarian cycle were infected. The rate of transovarial transmission was higher for progeny of Memphis than Chicago mosquitoes, and for mosquitoes held at 18 than 25 deg C; however, these differences were not statistically significant. Four positive pools were of females, and 3 were fed on chicks for transmission attempts. The positive Chicago mosquito pool failed to transmit, but both Memphis pools successfully transmitted virus. The overall rates of transovarial transmission of SLE virus in progeny of the first and second ovarian cycle were, respectively, 1/45 151 and 1/1460. The significance of these results as they relate to the natural history of SLE virus is discussed.
KW - cell lines
KW - detection
KW - mosquito nets
KW - transovarial transmission
KW - Aedes albopictus
KW - Culex
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - viruses
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Asian tiger mosquito
KW - complex
KW - mosquitoes
KW - Saint Louis encephalitis virus
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585675&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal trends and diurnal patterns of man-biting activity of four species of Guatemalan black flies (Simuliidae).
AU - Collins, R. C.
AU - Merino, M. E.
AU - Cupp, E. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 3
SP - 728
EP - 733
SN - 0002-9637
AD - Collins, R. C.: Central America Research Station, Bureau of Tropical Diseases, US Department of Health and Human Services, San Salvador, El Salvador.
N1 - Accession Number: 19810585679. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Collections from man and dissection of simuliids were carried out over a 13-month period at 2 sites where onchocerciasis (caused by Onchocerca volvulus) is endemic in Guatemala. Simulium ochraceum Wlk. comprised 87% of all flies collected. Populations of this species peaked during the first part of the dry season in November, while populations of S. metallicum Bellardi, S. callidum (D. & S.) and S. downsi Vargas, Martinez Palacios & Diaz Najera were highest during the rainy season from June-October. Diurnal patterns of host-seeking activity were most pronounced for S. ochraceum, with a sharp peak occurring between 07.00 and 09.00 h each day. The parous ratio was lowest at this time (27%) and rose to a peak of 63% between 12.00 and 14.00 h each day. Eighty-eight per cent. of all parous females of S. ochraceum collected during 12.00-14.00 h had large dilatations in the tunica of the ovarioles resulting from recent oviposition, thus indicating that this species oviposits in the morning and immediately seeks a blood-meal. Parous biting density (the product of the total number of flies biting at a given time and the corresponding parous ratio) showed 2 distinct diurnal peaks, one in the early morning characterised by a low parous ratio and high total number of flies, and the other in the early afternoon characterised by a high parous ratio and low total number of flies. The diurnal biting density pattern of filaria-infected S. ochraceum was similar to that of parous flies.
KW - behaviour
KW - feeding behaviour
KW - seasonal abundance
KW - Guatemala
KW - Diptera
KW - man
KW - Simuliidae
KW - Simulium
KW - Simulium callidum
KW - Simulium downsi
KW - Simulium metallicum
KW - Simulium ochraceum
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Diptera
KW - Simuliidae
KW - Simulium
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - behavior
KW - blackflies
KW - buffalo gnats
KW - feeding behavior
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810585679&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors affecting syncytial development in Aedes pseudoscutellaris cells by dengue viruses.
AU - Kuno, G.
AU - Moore, C. G.
AU - Sather, G. E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 4
SP - 870
EP - 875
SN - 0002-9637
AD - Kuno, G.: San Juan Laboratories, US Department of Health and Human Services, GPO Box 4532, San Juan, 00936, Puerto Rico.
N1 - Accession Number: 19810587229. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Several factors that were suspected of affecting the development of syncytia in cultured cells of Aedes pseudoscutellaris (Theo.) inoculated with dengue viruses were studied. The results indicated that fresh media (less than 1 week old), low cell density at inoculation (2.8 X 105 cells/cm2) and low cell passage level (less than 52 passages) favoured the development of syncytia. All 3 types (1, 2 and 3) of dengue viruses tested could be isolated from human sera by culture in A. pseudoscutellaris cells by using syncytial development as an indicator, but the isolation rate was lower than that obtained by using intrathoracically inoculated adults of A. aegypti (L.)
KW - cell lines
KW - isolation
KW - mosquito nets
KW - Aedes aegypti
KW - Aedes pseudoscutellaris
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - mosquitoes
KW - syncytia associated
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810587229&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiology of human babesiosis on Nantucket Island.
AU - Ruebush, T. K., II
AU - Juranek, D. D.
AU - Spielman, A.
AU - Piesman, J.
AU - Healy, G. R.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1981///
VL - 30
IS - 5
SP - 937
EP - 941
SN - 0002-9637
AD - Ruebush, T. K., II: Bureau of Epidemiology and Bureau of Laboratories, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19810587316. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - Between 1961 and 1977, 14 persons with parasitologically confirmed Babesia microti infections and 7 persons with antibody titres to B. microti of more than or equal to 1:1024 have been identified on Nantucket Island, Massachusetts, and Ixodes dammini Spielman, Clifford, Piesman & Corwin is probably the vector. Nineteen of these 21 persons were interviewed. About half were permanent residents of Nantucket; the others srent most of their summers on the island. There were 12 women and 7 men. Patients ranged in age from 23 to 86 years old; all of those with parasitologically confirmed infections were at least 49 years old. Fifteen patients had illnesses characterised by fever, chills, myalgia and fatigue. Five reported being bitten by a tick from 7 to 28 days before the onset of illness. Most cases occurred during July or August. There appeared to be no association between B. microti infection and direct contact with wild or domestic animals or specific outdoor activities. The unusual age-distribution of patients with parasitologically confirmed B. microti infections may result because older persons tend to have more severe illnesses and thus are more likely to come to medical attention.
KW - disease transmission
KW - epidemiology
KW - parasites
KW - transmission
KW - Massachusetts
KW - USA
KW - Acari
KW - Apicomplexa
KW - Babesia microti
KW - Ixodes scapularis
KW - man
KW - protozoa
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Babesia
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - human babesiosis
KW - Ixodes dammini
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810587316&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transmission of Ross River virus by Aedes polynesiensis and Aedes aegypti.
AU - Gubler, D. J.
JO - American Journal of Hygiene and Tropical Medicine
JF - American Journal of Hygiene and Tropical Medicine
Y1 - 1981///
VL - 30
IS - 6
SP - 1303
EP - 1306
AD - Gubler, D. J.: Vector-Borne Diseases Division, Bureau of Laboratories, Centers for Disease Control, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19820590095. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Laboratory studies were carried out with 2 geographical strains of Aedes polynesiensis Marks and 1 strain of A. aegypti (L.) to determine whether they could transmit Ross River virus. Both species were shown to be good vectors, but A. polynesiensis was the most susceptible. A. polynesiensis represents a new vector for this virus and the epidemiological implications of its spread by both mosquito species are discussed.
KW - disease transmission
KW - mosquito nets
KW - transmission
KW - Aedes aegypti
KW - Aedes polynesiensis
KW - Culicidae
KW - Diptera
KW - Ross River virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590095&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sudden death associated with very low calorie weight reduction regimens.
AU - Sours, H. E.
AU - Frattali, V. P.
AU - Brand, C. D.
AU - Feldman, R. A.
AU - Forbes, A. L.
AU - Swanson, R. C.
AU - Paris, A. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1981///
VL - 34
IS - 4
SP - 453
EP - 461
SN - 0002-9165
AD - Sours, H. E.: Food and Drug Administration (HFF-261) 200 C St. S.W., Washington, D.C., 20204, USA.
N1 - Accession Number: 19811426486. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Human Nutrition
N2 - In 17 patients who died suddenly of ventricular arrhythmia after prolonged use (median 5 months) of very-low-energy weight-reduction diets consisting entirely or largely of protein, death seemed to be independent of type of medical supervision received during the diet, daily dosage of potassium supplement or biological quality of the protein product used. Factors common to all patients were obesity at the onset of dieting, prolonged use of extremely low-energy diets (about 300 to 400 kcal daily) and significant and rapid weight loss. Review of available electrocardiograms and pathological specimens revealed a pattern of cardiac changes previously described in starvation.
KW - energy intake
KW - mortality
KW - obesity
KW - weight reduction
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - fatness
KW - sudden death during low energy diet in obesity
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811426486&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional factors in lead poisoning.
AU - Mahaffey, K. R.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1981///
VL - 39
IS - 10
SP - 353
EP - 362
SN - 0029-6643
AD - Mahaffey, K. R.: Division of Nutrition, Food and Drug Administration, 1090 Tusculum Ave., Cincinnati, OH 45226, USA.
N1 - Accession Number: 19811431555. Publication Type: Journal Article. Language: English. Number of References: 87 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-92-1, 1406-16-2, 7440-66-6. Subject Subsets: Human Nutrition
N2 - Susceptibility to lead intoxication, like many diseases, is influenced by age, genetic constitution and nutritional state with respect to energy, fat, vitamin D, calcium, iron and zinc. The tissues particularly vulnerable to lead toxicity are the nervous system, kidney and bone marrow. Pregnant women, young children and workers in lead factories are particularly susceptible to lead poisoning and should be the subjects of continuing public health surveillance.
KW - calcium
KW - energy intake
KW - fat
KW - iron
KW - lead
KW - nutritional state
KW - vitamin D
KW - zinc
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - nutritional state and lead poisoning
KW - nutritional status
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811431555&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mineral content of human tissues from a nutrition perspective.
AU - Fox, M. R. S.
AU - Tao, S. H.
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1981///
VL - 40
IS - 8
SP - 2130
EP - 2133
SN - 0014-9446
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Dep. Health and Human Services, Washington, D.C. 20204, USA.
N1 - Accession Number: 19811427088. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
KW - minerals
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - tissue content and nutrition
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811427088&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ultrastructural lesion in fetal hemopoietic cells following ethanol administration to pregnant mice.
AU - Nishimura, E. T.
AU - Beegle, R. G.
AU - Wolf, N. S.
JO - Laboratory Investigation
JF - Laboratory Investigation
Y1 - 1981///
VL - 45
IS - 4
SP - 342
EP - 346
SN - 0023-6837
AD - Nishimura, E. T.: Dep. Pathology, United States Public Health Service Hospital, 1131 14th Ave. South, Seattle, Wash. 98114, USA.
N1 - Accession Number: 19821433063. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition
N2 - Ethanol given by gavage to pregnant CF1 mice induced myelin-like laminar figures in mitochondria and Golgi complexes of proerythroblasts and erythroblasts in haemopoietically active foetal livers. The laminar figures were extruded by exotrophy in rare instances. The foetal haemopoietic tissues of sucrose-fed, sham and untreated pregnant mice rarely displayed laminar figures in immature erythroid cells.
KW - cells
KW - ethanol
KW - FETUS
KW - HAEMATOPOIESIS
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood formation
KW - ethyl alcohol
KW - foetus
KW - haemopoiesis
KW - hematopoiesis
KW - lesions in foetal haemopoietic cells after ethanol in pregnancy
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821433063&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nitrosamines in malt and malt beverages.
AU - Havery, D. C.
AU - Hotchkiss, J. H.
AU - Fazio, T.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1981///
VL - 46
IS - 2
SP - 501
EP - 505
SN - 0022-1147
AD - Havery, D. C.: Division of Chemistry and Physics, Bureau of Foods, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19811424704. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - The average N-nitrosodimethylamine (NDMA) content of 64 samples of locally purchased beer was 3 ng/g. Of 44 samples of 28 brands of Scotch whisky 11 had nondetectable amounts and 33 had from less than 1 to 2 ng/g. NDMA in 198 samples of malted barley was up to 86 ng/g with 31 samples having at least 10 ng/g. In a follow-up study to verify the effectiveness of a new malting process 180 domestic beer samples had NDMA up to 9, average less than 1 and 80 imported beers had up to 13, average 1 ng/g.
KW - alcoholic beverages
KW - beers
KW - beverages
KW - malt
KW - nitrosamines
KW - whisky
KW - drinks
KW - nitrosamines in malt and malt beverages
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811424704&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of polychlorinated biphenyls by chemical ionization mass spectrometry.
AU - Cairns, T.
AU - Siegmund, E. G.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1981///
VL - 53
IS - 11
SP - 1599
EP - 1603
AD - Cairns, T.: Dep. Health and Human Services, Food and Drug Administration, 1521 West Pico Blvd., Los Angeles, Calif. 90015, USA.
N1 - Accession Number: 19811430421. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - polychlorinated biphenyls
KW - PCBs
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811430421&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Animal models for assessing bioavailability of essential and toxic elements.
AU - Fox, M. R. S.
AU - Jacobs, R. M.
AU - Jones, A. O. L.
AU - Fry, B. E., Jr.
AU - Rakowska, M.
AU - Hamilton, R. P.
AU - Harland, B. F.
AU - Stone, C. L.
AU - Tao, S. H.
JO - Cereal Chemistry
JF - Cereal Chemistry
Y1 - 1981///
VL - 58
IS - 1
SP - 6
EP - 11
SN - 0009-0352
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Dep. Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19811422266. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - Different facets of experimantal design and response evaluation are examined and suggestions are made to improve animal models for predicting availability of elements for man.
KW - laboratory animals
KW - minerals
KW - trace elements
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal models for estimation of bioavailability of essential and toxic elements for man
KW - microelements
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811422266&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of methylene chloride and chloroform for the extraction of fats from food products.
AU - Chen, I. S.
AU - Shen, C. S. J.
AU - Sheppard, A. J.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1981///
VL - 58
IS - 5
SP - 599
EP - 601
SN - 0003-021X
AD - Chen, I. S.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19811426520. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Ten food samples with a wide range of total fat, fatty acids and sterols were analysed. Methylene chloride could replace chloroform, considered to be a carcinogen, in the usual extraction of lipids with chloroform and methanol (2:1).
KW - extraction
KW - fat
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811426520&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of identity of aflatoxins.
AU - Nesheim, S.
AU - Brumley, W. C.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1981///
VL - 58
IS - 12
SP - 945A
EP - 949A
SN - 0003-021X
AD - Nesheim, S.: Division of Chemistry and Physics, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19821435609. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Animal Nutrition
KW - aflatoxins
KW - estimation
KW - mycotoxins
KW - separation
KW - fungal toxins
KW - separating
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821435609&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dengue in the Seychelles.
AU - Calisher, C. H.
AU - Nuti, M.
AU - Lazuick, J. S.
AU - Ferrari, J. D. M.
AU - Kappus, K. D.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1981///
VL - 59
IS - 4
SP - 619
EP - 622
SN - 0042-9686
AD - Calisher, C. H.: Arbovirus Reference Branch, Vector-borne Diseases Division, US Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19820590142. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Epidemics of dengue-like illness occurred in the Seychelles between December 1976 and April 1977 and between December 1978 and January 1979. Subsequent tests on patients showed that all 4 dengue viruses were present in the islands but that dengue 2 was the most probable aetiological agent in the epidemics. Aedes albopictus (Skuse) develops in large numbers in the Seychelles during the rainy season (when the epidemics occurred) and this suggests that this mosquito is the principal vector [see RAE/B 69, 1825]. Monotypic antibodies to chikungunya and Sindbis viruses were also observed during these studies.
KW - dengue
KW - mosquito nets
KW - Seychelles
KW - Aedes albopictus
KW - chikungunya virus
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - man
KW - Sindbis virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flavivirus
KW - Flaviviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - Indian Ocean Islands
KW - Asian tiger mosquito
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820590142&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternal lead exposure inhibits intestinal calcium absorption in rat pups.
AU - Toraason, M. A.
AU - Barbe, J. S.
AU - Knecht, E. A.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 1981///
VL - 60
IS - 1
SP - 62
EP - 65
SN - 0041-008X
AD - Toraason, M. A.: US Dep. Health and Human Services, Public Health Service, Center for Disease Control, National Inst. Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19811431065. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7440-70-2, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Female rats were given a diet with 0.5% lead acetate for 5 weeks before mating, during gestation, and to day 17 of lactation. The effect on the maturation of duodenal calcium absorption in offspring 7 to 30 days old was temporary. At days 7 and 16, Ca uptake into duodenal tissue in vitro was low and there was no significant difference between control and exposed young rats. Between days 16 and 24, Ca absorption increased fourfold, which indicates the initiation of an active process for the uptake of Ca. Although Ca absorption increased in both groups, Ca accumulation was reduced in young rats 20 days old maternally exposed to Pb. By day 24, Ca absorption in Pb-exposed young rats was still decreased, but not significantly. Because only the mothers were given Pb, the exposure of young rats ended at weaning. As a result, blood Pb concentration dropped to control values at day 30 and there was no difference in Ca absorption between the groups.
KW - calcium
KW - lactation
KW - lead
KW - newborn animals
KW - pregnancy
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - maternal lead exposure and calcium absorption of progeny
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811431065&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hydrogen selenide evolution-electrothermal atomic absorption method for determining nanogram levels of total selenium.
AU - Cox, D. H.
AU - Bibb, A. E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 2
SP - 265
EP - 269
AD - Cox, D. H.: Public Health Service, Center for Disease Control, Toxicology Branch, Atlanta, GA 30333, USA.
N1 - Accession Number: 19811424937. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science
KW - assays
KW - Chemical analysis
KW - estimation
KW - Liver
KW - selenium
KW - Spectrophotometry
KW - Urine
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811424937&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sampling procedure and determination of lead in canned foods.
AU - Suddendorf, R. F.
AU - Wright, S. K.
AU - Boyer, K. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 3
SP - 657
EP - 660
AD - Suddendorf, R. F.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19811426562. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - The sampling procedure and rapid estimation of lead in canned food by chelation-extraction and absorption spectrometry are described.
KW - canned products
KW - canning
KW - composition
KW - estimation
KW - foods
KW - lead
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811426562&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid method for estimation of N-nitrosodimethylamine in malt beverages.
AU - Hotchkiss, J. H.
AU - Havery, D. C.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 4
SP - 929
EP - 932
AD - Hotchkiss, J. H.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19811428506. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The estimation of N-nitrosodimethylamine by gas chromatography is described. Values for 20 malt beverages, 13 of lager, range up to 13.3 ng/g.
KW - alcoholic beverages
KW - beers
KW - beverages
KW - malt
KW - nitrosamines
KW - drinks
KW - estimation of nitrosodimethylamine content of malt beverages
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811428506&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simplified apparatus for determination of mercury by atomic absorption and inductively coupled plasma emission spectroscopy.
AU - Suddendorf, R. F.
AU - Watts, J. O.
AU - Boyer, K.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 5
SP - 1105
EP - 1110
AD - Suddendorf, R. F.: Food and Drug Administration, Division of Chemical Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19821967611. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 7439-97-6. Subject Subsets: Soils & Fertilizers; Human Nutrition
N2 - A simplified apparatus has been applied to the determination of mercury by cold vapor generation. The equipment consists of a reaction flask incorporating a side arm in which a rubber septum is mounted. A sample solution is injected from a syringe through the rubber septum into the reaction flask, where it is mixed with a stannous chloride reducing solution. The elemental mercury generated is then swept with a carrier gas to the inductively coupled plasma (ICP), an absorption cell of an atomic absorption spectrometer, or a nondispersive UV monitor for determination. Detection limits were 0.009 and 0.005 mu g with atomic absorption and the UV monitor, respectively, and 0.09 mu g with the ICP. Repeatability of the procedure was 1.4% at 0.66 mu g injected mercury with the ICP and 5.2% at 0.45 mu g injected with atomic absorption. Tuna and halibut samples fortified with from 0.09 to 1.31 mu g mercury/g were analyzed by the AOAC official method and the procedure described here. The average mercury recovery was 103% with the ICP, and 99% with the UV monitor and with atomic absorption. The procedure is free from interference by elements commonly present in biological material.[TVA]
KW - ANALYTICAL METHODS
KW - atomic absorption spectrophotometry
KW - estimation
KW - mercury
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Research (AA500)
KW - Development Aid, Agencies and Projects (EE450) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821967611&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High pressure liquid chromatographic determination of ethoxyquin in paprika and chili powder.
AU - Perfetti, G. A.
AU - Warner, C. R.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 6
SP - 1453
EP - 1456
AD - Perfetti, G. A.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19821433521. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 91-53-2. Subject Subsets: Human Nutrition
KW - estimation
KW - ethoxyquin
KW - santoquin
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821433521&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of N-nitrosodimethylamine in beer.
AU - Andrzejewski, D.
AU - Havery, D. C.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1981///
VL - 64
IS - 6
SP - 1457
EP - 1461
AD - Andrzejewski, D.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19821433522. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - N-Nitrosodimethylamine was estimated using a gas chromatograph interfaced to a thermal energy analyser. Values up to 7.7 ng/g were obtained for 60 of 64 samples of beer.
KW - beers
KW - beverages
KW - nitrosamines
KW - drinks
KW - estimation of beer nitrosodimethylamine
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821433522&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Glucose disposal and gluconeogenesis from alanine in tumor-bearing Fischer 344 rats.
AU - Lowry, S. F.
AU - Foster, D. M.
AU - Norton, J. A.
AU - Berman, M.
AU - Brennan, M. F.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1981///
VL - 66
IS - 4
SP - 653
EP - 658
SN - 0027-8874
AD - Lowry, S. F.: Surgical Metabolism Section, Surgery Branch, Division of Cancer Treatment, National Cancer Inst., (NCI), National Insts. Health, Public Health Service, US Dep. Health and Human Services, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19811428168. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 56-41-7, 50-99-7. Subject Subsets: Human Nutrition
N2 - For the study of glucose carbon recycling and incorporation of carbon atoms from plasma alanine into plasma glucose, [3-3H]glucose and [3-3C]alanine were injected into inbred nontumour-bearing (NTB) and tumour-bearing (TB) male F344 rats. The glucose and alanine kinetics were estimated in relation to antecedent food intake and carcass weight loss. Whereas fed NTB and TB rats appropriately experienced reduced glucose disposal with decreased food intake, starved TB rats exhibited increased glucose utilization. Fully fed and cachectic TB groups exhibited increased isotopic carbon recycling compared with the carbon recycling of NTB control groups, whereas starved TB rats did not show increased recycling (27% of C-atoms recycled).
KW - alanine
KW - gluconeogenesis
KW - glucose
KW - tumours
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - tumors
KW - tumours on glucose disposal and gluconeogenesis from alanine
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811428168&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of three retinoids on tracheal carcinogenesis with N-methyl-N-nitrosourea in hamsters.
AU - Stinson, S. F.
AU - Reznik, G.
AU - Donahoe, R.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1981///
VL - 66
IS - 5
SP - 947
EP - 951
SN - 0027-8874
AD - Stinson, S. F.: Tumor Pathology Branch, National Toxicology Program, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health and Human Services, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19811429016. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - Male Syrian golden hamsters received 12 weekly intratracheal exposures to 0.5% N-methyl-N-nitrosourea with a special catheter. After exposures, hamsters were randomized into 4 groups of 63 each and placed on diets of laboratory meal or meal with 13-cis-retinoic acid (CRA) 120, ethylretinamide (ER) 327, or N-(2-hydroxyethyl)retinamide (HR) 343 mg/kg for 6 months and were then killed. The incidences of tracheal epithelial neoplasms were 10/63 with laboratory meal, 22/61 with CRA, 24/63 with ER and 17/62 with HR. The incidences of carcinomata were 4/63, 12/61, 12/63 and 11/62, respectively. The weight loss and mortality relative to those in the group fed on the laboratory meal were significant in the group given HR but not in the other retinoid-treated groups.
KW - carcinogenesis
KW - retinoids
KW - trachea
KW - retinoids affect tracheal carcinogenesis (hamster)
KW - vitamin A compounds
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811429016&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Osseous changes and osteosacomas in mice continuously fed diets containing diethylstilbestrol or 17 beta -estradiol.
AU - Highman, B.
AU - Roth, S. I.
AU - Greenman, D. L.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1981///
VL - 67
IS - 3
SP - 653
EP - 662
SN - 0027-8874
AD - Highman, B.: Division of Pathology Services, National Center for Toxicological Research, Food and Drug Administration, US Dep. Health and Human Services, Jefferson, Ark. 72079, USA.
N1 - Accession Number: 19821432358. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 56-53-1, 50-28-2. Subject Subsets: Human Nutrition
N2 - In a study on the long-term effects of dietary diethylstilboestrol or 17 beta -oestradiol on C3H mice, oestrogens induced a proliferation of osseous trabeculae and increased the incidence and hastened the development of osteofibrotic areas in the sterna. There were 6 osteosarcomata, 2 having metastases, in 1242 mice given dietary oestrogens for 360 days, but none in 356 untreated controls. The tumours were reviewed along with 4 early sternal osteosarcomata selected from 17 osteosarcomata found thus far in 2 other ongoing comparable studies. In at least 1 instance, and possibly in 2 other early cases, tumours were associated with areas of osteofibrosis, and 1 tumour was probably associated with proliferation of bony trabeculae in the medullary cavity.
KW - bones
KW - DIETHYLSTILBESTROL
KW - ESTRADIOL
KW - neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - diethylstilboestrol
KW - oestradiol
KW - oestrogens on bone
KW - stilboestrol
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821432358&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Esophageal cancer among black men in Washington, D.C. 2. Role of nutrition.
AU - Ziegler, R. G.
AU - Morris, L. E.
AU - Blot, W. J.
AU - Pottern, L. M.
AU - Hoover, R.
AU - Fraumeni, J. F., Jr.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1981///
VL - 67
IS - 6
SP - 1199
EP - 1206
SN - 0027-8874
AD - Ziegler, R. G.: Environmental Epidemiology Branch, Division of Cancer Cause and Prevention, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health and Human Services, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19821434748. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - For part 1 see NAR/A 52, 5820. 2. In a case-control study of oesophageal cancer among the black male residents of Washington, D.C., to find reasons for the exceptionally high risk in that group, the next of kin of 120 oesophageal cancer patients who died during 1975-77 and of 250 D.C. black men who died of other causes were interviewed. Five indicators of general nutritional state, intake of fresh or frozen meat and fish, intake of dairy products and eggs, intake of fruit and vegetables, relative weight (wt/ht2) and number of meals eaten per day, were each significantly and inversely correlated with the relative risk of oesophageal cancer. Association with other food groups was not apparent. The least nourished third of the study group, defined by any of those 5 measures, was at twice the risk of the most nourished third. None of those associations was much decreased by controlling for ethanol consumption, the other major risk factor in the group, or smoking or socioeconomic status or the other nutrition measures. When intakes of the 3 food groups were combined into a single overall index of general nutritional state, the relative risk of oesophageal cancer between extremes was 14. Estimates of the intake of vitamin A, carotene, vitamin C, thiamin and riboflavin were inversely associated with relative risk, but each micronutrient index was less strongly associated with risk than were the broad food groups which provide most of the micronutrient. Thus no specific micronutrient deficiency was identified. Instead, generally poor nutrition was the main dietary predictor of risk and may partly explain the susceptibility of urban black men to oesophageal cancer.
KW - neoplasms
KW - oesophagus
KW - District of Columbia
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - diet and oesophageal cancer in Washington D.C
KW - esophagus
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821434748&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimation of dietary iodine intake of Americans in recent years.
AU - Park, Y. K.
AU - Harland, B. F.
AU - Venderveen, J. E.
AU - Shank, F. R.
AU - Prosky, L.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1981///
VL - 79
IS - 1
SP - 17
EP - 24
SN - 0002-8223
AD - Park, Y. K.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19811428382. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition
N2 - Iodine content of diets for infants, young children and adults in USA was far in excess of the requirement. Main source was dairy produce, followed by, for adults, grain and cereal products, sugar and sugar foods, meat, fish and poultry; for children, grain, cereals, meat, fish and poultry.
KW - diet studies
KW - iodine
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dietary iodine intake in USA
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811428382&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The resurgence of malaria -- diagnostic and therapeutic dilemmas.
AU - Quinn, T. C.
AU - Plorde, J. J.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 1981///
VL - 141
IS - 9
SP - 1123
EP - 1124
SN - 0003-9926
AD - Quinn, T. C.: Trop. Med. Clinic, Public Health Service Hospital, 1131 14 Avs. Seattle, WA 98114, USA.
N1 - Accession Number: 19810890802. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology
N2 - The reasons for the unsatisfactory response of the US medical establishment to the problems posed by the rapid increase of malaria cases in the USA are discussed and emphasis is given to the need for rapid and accurate diagnosis and effective prophylaxis for travellers.
KW - parasites
KW - travel
KW - USA
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Haemosporida
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19810890802&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Resolution of fat-soluble vitamins in high-performance liquid chromatography with methanol-containing mobile phases.
AU - Landen, W. O., Jr.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1981///
VL - 211
IS - 1
SP - 155
EP - 159
SN - 0021-9673
AD - Landen, W. O., Jr.: Food and Drug Administration, 1182 W. Peachtree Street, Atlanta, GA 30309, USA.
N1 - Accession Number: 19811427000. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 68-26-8, 1406-16-2. Subject Subsets: Human Nutrition
N2 - Compounds of vitamins A and D were separated by chromatography on Zorbax ODS with solvent methylene chloride (containing 0.001% triethylamine) and acetonitrile (3:7), with methanol 0 to 40 ml/litre of mixture.
KW - RETINOL
KW - separation
KW - vitamin D
KW - axerophthol
KW - separating
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19811427000&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - First report of Culex chrysonotum and Culex spissipes in Guatemala (Diptera, Culicidae).
AU - Darsie, R. F., Jr.
AU - Hobbs, J. H.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1982///
VL - 14
IS - 1
SP - 73
EP - 77
SN - 0091-3669
AD - Darsie, R. F., Jr.: Center for Infectious Diseases, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19820596135. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Culex chrysonotum D. & K. and C. spissipes (Theob.) are recorded for the 1st time in Guatemala, being collected as adults in traps and (in the case of the 1st species only) as larvae and pupae from freshwater ground pools. The adult male of the 2nd species has not yet been taken in Guatemala, and the larva appears not to have been described, but distinguishing characters are given in a couplet for the females of the 2 species.
KW - mosquito nets
KW - taxonomy
KW - Guatemala
KW - Culex spissipes
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Culicidae
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - characters distinguishing C. chrysonotum
KW - characters distinguishing C. spissipes
KW - Culex chrysonotum
KW - mosquitoes
KW - systematics
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820596135&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ion-pair high-pressure liquid chromatography of cis-trans isomers of retinoic acid in tissues of vitamin A-sufficient rats.
AU - Sundaresan, P. R.
AU - Bhat, P. V.
JO - Journal of Lipid Research
JF - Journal of Lipid Research
Y1 - 1982///
VL - 23
IS - 3
SP - 448
EP - 455
SN - 0022-2275
AD - Sundaresan, P. R.: Division of Toxicology, Bureau of Foods, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19821436980. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 302-79-4, 68-26-8. Subject Subsets: Human Nutrition
N2 - A mixture of 4-oxoretinoic acid (RA), retinyl phosphate, 13-cis RA, all-trans RA, retinol, retinal, retinyl acetate, anhydroretinol and retinyl palmitate was separated by chromatography on an octadecylsilane column with acetonitrile and potassium phosphate buffer, pH 7.2, (54:46) then 98% acetonitrile as solvent. Studies with rats showed that 13-cis RA is partly isomerized to all-trans RA and that all-trans RA is rapidly metabolized to highly polar compounds.
KW - retinoic acid
KW - RETINOL
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - estimation and metabolism of retinoic acid in vitamin A deficiency
KW - tretinoin
KW - vitamin A
KW - vitamin A acid
KW - vitamin A alcohol
KW - vitamin A1
KW - Techniques and Methodology (ZZ900)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821436980&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A candidate reference method for uric acid in serum. 1. Optimization and evaluation.
AU - Duncan, P. H.
AU - Gochman, N.
AU - Cooper, T.
AU - Smith, E.
AU - Bayse, D.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1982///
VL - 28
IS - 2
SP - 284
EP - 290
SN - 0009-9147
AD - Duncan, P. H.: US Dep. Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta, GA 30333, USA.
N1 - Accession Number: 19821435590. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 69-93-2. Subject Subsets: Human Nutrition
N2 - 1. All 6 methods examined were satisfactory for estimating uric acid in serum. A manual method using microbial uricase and measurement of absorbance at 283 nm was chosen as the candidate Reference Method.
KW - estimation
KW - serum
KW - uric acid
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821435590&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interlaboratory surveys of the quantitation of thyroxine and thyrotropin (thyroid-stimulating hormone) in dried blood spot specimens.
AU - Hearn, T. L.
AU - Hannon, W. H.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1982///
VL - 28
IS - 10
SP - 2022
EP - 2025
SN - 0009-9147
AD - Hearn, T. L.: Licensure and Proficiency Testing Division, Lab. Improvement Program Office, Public Health Service, US Dep. Health and Human Services, Altanta, GA 30333, USA.
N1 - Accession Number: 19831443394. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 9034-48-4, 51-48-9. Subject Subsets: Human Nutrition
KW - estimation
KW - thyrotropin
KW - thyroxine
KW - thyroid-stimulating hormone
KW - thyrotropic hormone
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831443394&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid-chromatographic measurement of phenylalanine and tyrosine in serum.
AU - Spierto, F. W.
AU - Whitfield, W.
AU - Apetz, M.
AU - Hannon, W. H.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1982///
VL - 28
IS - 11
SP - 2282
EP - 2285
SN - 0009-9147
AD - Spierto, F. W.: Clinical Chemistry Division, Center for Environmental Health, Centres for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19831443438. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 63-91-2, 60-18-4. Subject Subsets: Human Nutrition
N2 - Serum is treated with phenylalanine ammonia-lyase (EC 4.3.1.5) to covert phenylalanine and tyrosine to trans-cinnamic and p-coumaric acid, respectively. Those acids are separated from protein-free serum by reversed-phase chromatography and estimated at 280 nm.
KW - blood
KW - estimation
KW - phenylalanine
KW - tyrosine
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831443438&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antigenic relationships of flaviviruses with undetermined arthropod-borne status.
AU - Varelas-Wesley, I.
AU - Calisher, C. H.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1982///
VL - 31
IS - 6
SP - 1273
EP - 1284
SN - 0002-9637
AD - Varelas-Wesley, I.: Vector-Borne Diseases Division, Centers for Disease Control, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19830599779. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science
N2 - In contrast to most of the arthropod-borne flaviviruses, the flaviviruses with undetermined arthropod-borne status are probably disseminated only by direct contact with excreta (saliva, urine, faeces, etc.); however, as yet undescribed arthropod transmission cycles may be found for some of them. Twenty-two of these flaviviruses, including prototype and recently isolated strains, were compared. Biological properties were defined by infectivity titrations in suckling mice and Vero, LLC-MK2, and primary Pekin duck embryo cells, and antigenic relationships were defined by complement-fixation and plaque reduction neutralisation tests. An antigenic classification scheme is proposed. Antigenic and biological properties delimit 2 large clusters. The first, comprising a single antigenic complex, includes those which have yet to be isolated from arthropods, but are likely to be so (Israel turkey meningoencephalitis, Koutango, Negishi and Aroa viruses). The second, encompassing 5 antigenic complexes, is composed of viruses which have been isolated exclusively from rodents or bats but includes 3 viruses (Saboya, Sokuluk and Entebbe bat viruses) which may be arthropod-borne, as indicated by replication in mosquito cells in vitro.
KW - antigens
KW - arboviruses
KW - relationships
KW - Aroa virus
KW - Culicidae
KW - Diptera
KW - Entebbe bat virus
KW - flavivirus
KW - Koutango virus
KW - Saboya virus
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flavivirus
KW - antigenicity
KW - arthropod-borne viruses
KW - immunogens
KW - Israel turkey encephalitis virus
KW - mosquitoes
KW - Negishi virus
KW - Sokuluk virus
KW - Turkey meningoencephalitis virus
KW - Medical and Veterinary Entomology Records (TT300) (Discontinued 1995)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830599779&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children.
AU - Mahaffey, K. R.
AU - Rosen, J. F.
AU - Chesney, R. W.
AU - Peeler, J. T
AU - Smith, C. M.
AU - DeLuca, H. F.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1982///
VL - 35
IS - 6
SP - 1327
EP - 1331
SN - 0002-9165
AD - Mahaffey, K. R.: Food and Drug Administration, 1090 Tusculum Ave., Cincinatti, OH 45226, USA.
N1 - Accession Number: 19831445608. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 32222-06-3, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Serum 1,25-dihydroxycholecalciferol (1,25-CC), the form of vitamin D active in stimulating intestinal absorption of calcium, phosphorus and lead, was estimated in 177 subjects 1 to 16 years old. There was a significant negative association between serum 1,25-CC and blood Pb concentrations over the entire range of blood Pb values, 12 to 120 mu g/100 ml. Adolescents 11 to 16 years old had serum 1,25-CC values higher than those among children 10 years old or younger. No effect of sex or season on serum 1,25-CC was observed. When the 1,25-CC values for children with blood Pb concentrations greater than 30 mu g/100 ml were excluded from the analysis, no significant effect of geographical location on 1,25-CC values was observed.
KW - age
KW - blood
KW - CALCITRIOL
KW - children
KW - lead
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 1,25-dihydroxycholecalciferol
KW - 1,25-dihydroxyvitamin D
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831445608&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition labeling and public health: survey of American Institute of Nutrition members, food industry, and consumers.
AU - Heimbach, J. T.
AU - Stokes, R. C.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1982///
VL - 36
IS - 4
SP - 700
EP - 708
SN - 0002-9165
AD - Heimbach, J. T.: Food and Drug Administration, Bureau of Foods, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19831447355. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The 531 members of the American Institute of Nutrition, 177 persons from the food industry and 107 consumers from a Food and Drug Administration mailing list who responded to a survey dealing with nutrition labelling of foods identified obesity and heart disease as the major diet-related national health problems and chose information about energy, sodium, fat, protein, iron, calcium and carbohydrates as most useful to the public.
KW - cardiovascular diseases
KW - food legislation
KW - nutrition education
KW - obesity
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831447355&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mites and other filth in dried shrimp imported into the United States from the Orient.
AU - Olsen, A. R.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1982///
VL - 45
IS - 13
SP - 1204
EP - 1207
SN - 0362-028X
AD - Olsen, A. R.: Food and Drug Administration, Los Angeles, California 90015, USA.
N1 - Accession Number: 19830506942. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Agricultural Entomology
N2 - Significant quantities of 'filth' (including insect fragments, whole insects, mites, rodent hairs and feather fragments) were found in 21 of 50 samples of dried shrimp imported into the USA from Hong Kong, Taiwan, Thailand, Singapore, the Philippines, Japan, Malaysia and Indonesia. Details are given of the frequency of occurrence of each type of contaminant. The mites present included Lardoglyphus konoi (Sasa & Asanuma), and new distribution records for this species resulting from these findings include Indonesia, Malaysia, the Philippines and Singapore. The pyroglyphid house-dust mites present included Dermatophagoides sp.
KW - agricultural entomology
KW - commodities
KW - distribution
KW - imports
KW - stored products
KW - Asia
KW - Indonesia
KW - Malaysia
KW - Philippines
KW - Singapore
KW - USA
KW - arthropods
KW - Dermatophagoides
KW - Lardoglyphus konoi
KW - Pyroglyphidae
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - Arachnida
KW - arthropods
KW - Lardoglyphus
KW - Lardoglyphidae
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Commonwealth of Nations
KW - Threshold Countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dried shrimps
KW - United States of America
KW - Biodeterioration, Storage Problems and Pests of Animal Products (SS110) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830506942&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of gel permeation chromatography and nonaqueous reverse phase chromatography to high performance liquid chromatographic determination of retinyl palmitate and alpha -tocopheryl acetate in infant formulas.
AU - Landen, W. O., Jr.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1982///
VL - 65
IS - 4
SP - 810
EP - 816
AD - Landen, W. O., Jr.: Food and Drug Administration, 1182 W Peachtree St., NW, Atlanta, GA 30309, USA.
N1 - Accession Number: 19821439894. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 79-81-2, 58-95-7. Subject Subsets: Human Nutrition
KW - estimation
KW - infant foods
KW - retinyl palmitate
KW - vitamin E acetate
KW - alpha-tocopheryl acetate
KW - baby foods
KW - retinol palmitate
KW - tocopheryl acetate
KW - vitamin A palmitate
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821439894&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicology of lead: primer for analytical chemists.
AU - Biddle, G. N.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1982///
VL - 65
IS - 4
SP - 947
EP - 952
AD - Biddle, G. N.: Food and Drug Administration, Division of Toxicology, Washington, DC 20204, USA.
N1 - Accession Number: 19821439903. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Through the years, considerable amounts of lead have been mobilized into the environment and Pb may represent one of the most ubiquitous of all toxic metal contaminants. Excluding occupational exposure, the general population receives almost 70% of its total exposure to Pb from food. Other important sources of exposure include drinking water and air; minor sources include tobacco products, decorative glassware and other types of food utensils. For young children, ingestion of Pb-containing soil or dust through normal hand-to-mouth activity or, in extreme cases, pica (the abnormal intake of soil, paint chips and other materials) may represent a significant source of exposure. The severity of clinical manifestations of Pb toxicity depends on duration and intensity of exposure. Infants and young children are more susceptible to the effects of Pb than are adults. Although there is little debate over the serious consequences of acute, high-level Pb exposure, controversy and concern have been expressed about the degree of risk which may be associated with chronic exposure to Pb in amounts which are closer to those contemporary in the general environment. That concern is particularly great for infants and young children, who may undergo Pb-induced changes which have long-term neurological impact, such as learning deficits, gross or fine motor dysfunction or both and impaired cognitive abilities.
KW - lead
KW - sources
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821439903&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of background levels of lead and cadmium in raw agricultural crops by using differential pulse anodic stripping voltammetry.
AU - Satzger, R. D.
AU - Clow, C. S.
AU - Bonnin, E.
AU - Fricke, F. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1982///
VL - 65
IS - 4
SP - 987
EP - 991
AD - Satzger, R. D.: Food and Drug Administration, Elemental Analysis Research Center, Cincinnati, OH 45202, USA.
N1 - Accession Number: 19851996411. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition; Soils & Fertilizers; Animal Nutrition
N2 - A method is described for the simultaneous determination of ultratrace levels of lead and cadmium in selected agricultural crop samples by differential pulse anodic stripping voltammetry. Samples are dry ashed at high temperature with H2SO4 as an ashing aid. Techniques are described to control the lead and cadmium blank levels of 2 ng and 0.4 ng, respectively. Typical relative standard deviations for the crop analyses are 13% at 100 ng/g and 25% at 10 ng/g for lead, and 5% at 100 ng/g and 10% at 10 ng/g for cadmium. The lowest quantifiable level, based on 3 g dry sample, is 2 ng/g for lead and 1 ng/g for cadmium. Recovery studies, precision studies, and analyses of NBS Standard Reference Materials demonstrate the accuracy and reproducibility of this technique. A summary of results for over 1700 crop samples is reported.
KW - Cadmium
KW - estimation
KW - Lead
KW - plant analysis
KW - Soil Fertility (JJ600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851996411&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enzymatic determination of cholesterol in egg yolk.
AU - Shen, C. S. J.
AU - Chen, I. S.
AU - Sheppard, A. J.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1982///
VL - 65
IS - 5
SP - 1222
EP - 1224
AD - Shen, C. S. J.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19821441048. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - A test kit with cholesterol oxidase was used to estimate cholesterol in egg yolk. Values were similar to those obtained by gas-liquid chromatography.
KW - cholesterol
KW - egg yolk
KW - estimation
KW - yolk
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821441048&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors for breast cancer in women in northern Alberta, Canada, as related to age at diagnosis.
AU - Lubin, J. H.
AU - Burns, P. E.
AU - Blot, W. J.
AU - Lees, A. W.
AU - May, C.
AU - Morris, L. E.
AU - Fraumeni, J. F., Jr.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1982///
VL - 68
IS - 2
SP - 211
EP - 217
SN - 0027-8874
AD - Lubin, J. H.: Environmental Epidemiology Branch, Division of Cancer Cause and Prevention, National Cancer Inst., National Insts. Health, Public Health Service, US Dep. Health and Human Services, Bethesda, Md. 20205, USA.
N1 - Accession Number: 19821438212. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - A population-based case-control study involving interviews with 577 female breast cancer patients and 826 controls in northern Alberta, Canada, showed that some determinants of breast cancer varied according to age. Among women under 45 years old risk factors included a younger age at menarche, late age at last birth, high parity and recent use of oral contraceptives. At older ages risk was related to natural as opposed to surgical menopause, late age at first birth, low parity, late age at natural menopause and tonsillectomy. At all ages there was increased risk of breast cancer associated with difficulty in conceiving, benign breast disease, not having breast fed and a history of breast cancer among mothers or sisters. For some variables the age differences were pronounced; the combination of low parity and late age at first birth was associated with a 7-fold increase in breast cancer risk at 55 to 80 years old but a slight decrease at under 45. The effect of tonsillectomy steadily increased with age, but certain features suggested that the link with oral contraceptives among younger women and the inverse relation to breast feeding at all ages may not be causal. Even though design limitations (patients interviewed in a different setting from controls) seemed not to influence conclusions, the results may have been subjected to interview bias and thus should be interpreted cautiously.
KW - age
KW - carcinoma
KW - mammary glands
KW - Canada
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821438212&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perspective of Food and Drug Administration on dietary sodium.
AU - Shank, F. R.
AU - Park, Y. K.
AU - Harland, B. F.
AU - Vanderveen, J. E.
AU - Forbes, A. L.
AU - Prosky, L.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1982///
VL - 80
IS - 1
SP - 29
EP - 35
SN - 0002-8223
AD - Shank, F. R.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19821439393. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-23-5, 7440-09-7. Subject Subsets: Human Nutrition
N2 - Tables give the sodium and potassium content by analysis for representative total diet in USA in 1977, 1978 and 1979 for infants, young children and adults, and the amount in mg and the percentage of total intake of Na and K contributed by drinking water (for the 2 younger groups), by each of 9 or 10 groups of foods and by total beverages. Findings are discussed.
KW - diet studies
KW - diets
KW - potassium
KW - sodium
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821439393&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antigenic relationships among Tacaiuma complex viruses of the Anopheles A serogroup (Bunyaviridae). / Relaciones antigenicas entre virus del complejo Tacaiuma del serogrupo Anopheles A (Bunyviridae).
AU - Calisher, C. H.
AU - Lazuick, J. S.
AU - Muth, D. J.
AU - Lopes, O. de S.
AU - Crane, G. T,
AU - Elbel, R. E.
AU - Shope, R. E.
JO - Boletin de la Oficina Sanitaria Panamericana
JF - Boletin de la Oficina Sanitaria Panamericana
Y1 - 1982///
VL - 92
IS - 1
SP - 41
EP - 48
SN - 0030-0632
AD - Calisher, C. H.: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, USDHEW, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19820593482. Publication Type: Journal Article. Language: Spanish. Language of Summary: English; Portuguese; French. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This paper on 2 new viruses of the Anopheles A group isolated from Anopheles freeborni Aitken in Arizona and from a woman in Brazil, respectively, has already been noticed from a version in English [RAE/B 69, 2949].
KW - mosquito nets
KW - Arizona
KW - USA
KW - Anopheles freeborni
KW - Culicidae
KW - Diptera
KW - viruses
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - mosquitoes
KW - United States of America
KW - Virgin River virus
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19820593482&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Critical evaluation of a multi-element scheme using plasma emission and hydride evolution atomic-absorption spectrometry for the analysis of plant and animal tissues.
AU - Jones, J. W.
AU - Capar, S. G.
AU - O'Haver, T. C.
JO - Analyst
JF - Analyst
Y1 - 1982///
VL - 107
IS - 1273
SP - 353
EP - 377
SN - 0003-2654
AD - Jones, J. W.: Division of Chemical Technology, US Food and Drug Administration, 200 C Street, S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19821969993. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Soils & Fertilizers; Human Nutrition; Animal Nutrition
N2 - An analytical scheme that uses inductively coupled argon plasma emission spectroscopy (ICAP) and hydride evolution atomic-absorption spectrometry (HEAA) for the determination of trace elements in plant and animal tissues has been evaluated. The scheme incorporates the ion-exchange procedure of Kingston et al., which uses Chelex 100 resin to concentrate trace elements and remove potentially interfering alkali and alkaline earth metals. The separation procedure is included in a scheme designed to maximise the number of analyte metals that can be determined from a single digestion of a biological matrix. Acid-digested samples are divided into two fractions. One fraction (5% of the total) is measured directly by ICAP for alkali and alkaline earth metals and phosphorus and for transition metals such as iron and manganese, which are not well behaved on the resin. The other fraction (95% of the total) is subjected to the separation procedure whereby a number of biologically important trace elements, including cadmium, copper, molybdenum, nickel, vanadium and zinc, are initially sequestered by the resin, and then stripped into a small volume of dilute nitric acid for ICAP measurement of the "matrix-free" analytes. Arsenic, selenium and antimony, which are not retained by the resin, are collected with the initial column effluent, acidifed and determined by HEAA. The reliability of the scheme is influenced by the nature of the acid digestion procedure used to oxidise the organic matrix. The scheme was tested by analysis of ten National Bureau of Standards biological reference materials.[TVA]
KW - analysis
KW - ANALYTICAL METHODS
KW - atomic absorption spectrophotometry
KW - atomic absorption spectroscopy
KW - estimation
KW - minerals
KW - plant composition
KW - spectroscopy
KW - tissues
KW - trace elements
KW - analytical techniques
KW - chemical constituents of plants
KW - microelements
KW - plant material
KW - plasma emission
KW - Techniques and Methodology (ZZ900)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821969993&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of methylmercury in fish by high-performance liquid chromatography.
AU - Holak, W.
JO - Analyst
JF - Analyst
Y1 - 1982///
VL - 107
IS - 1281
SP - 1457
EP - 1461
SN - 0003-2654
AD - Holak, W.: Food and Drug Administration, Dep. Health and Human Services, New York Regional Lab., 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19831443744. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 593-74-8. Subject Subsets: Human Nutrition; Veterinary Science
KW - assays
KW - estimation
KW - FISH
KW - mercury compounds
KW - methylmercury
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831443744&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Separation of some natural and synthetic corticosteroids in biological fluids and tissues by high-performance liquid chromatography.
AU - Althaus, Z. R.
AU - Rowland, J. M.
AU - Freeman, J. P.
AU - Slikker, W., Jr.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1982///
VL - 227
IS - 1
SP - 11
EP - 23
SN - 0021-9673
AD - Althaus, Z. R.: Dep. Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19821433460. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
KW - CORTICOIDS
KW - corticosteroids
KW - separation of natural and synthetic corticosteroids
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821433460&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and utilization of a procedure for measuring urinary porphyrins by high-performance liquid chromatography.
AU - Hill, R. H., Jr.
AU - Bailey, S. L.
AU - Needham, L. L.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1982///
VL - 232
IS - 2
SP - 251
EP - 260
SN - 0021-9673
AD - Hill, R. H., Jr.: Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19831443796. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - porphyrins
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831443796&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National estimates of blood lead levels: United States, 1976-1980. Association with selected demographic and socioeconomic factors.
AU - Mahaffey, K. R.
AU - Annest, J. L.
AU - Roberts, J.
AU - Murphy, R. S.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1982///
VL - 307
IS - 10
SP - 573
EP - 579
SN - 0028-4793
AD - Mahaffey, K. R.: Division of Nutrition, Food and Drug Administration, 1090 Tusculum Ave., Cincinnati, OH 45226, USA.
N1 - Accession Number: 19821442189. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Data from the second National Health and Nutrition Examination Survey showed that 22% of persons 6 months to the end of 74 years old had blood lead values under 10 mu g/100 ml; 1.9% had high values, 30 mu g/100 ml (1.45 mu mol/litre) or more. Among children 6 months to the end of 5 years old the prevalence of high values was significantly greater (4%) than previously predicted on the basis of less information. The prevalence of high Pb values was 12.2% in black children and 2.0% in white children. Mean blood Pb values were higher in black than in white children and adults, in young children living in urban and rural areas and among members of low-, moderate- and high-income families. Those racial contrasts may reflect different Pb exposure or absorption, or both. Young children from black and white families whose incomes were under $6000 had a significantly higher prevalence of high Pb values than those from households with incomes of $6000 or more.
KW - blood
KW - lead
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19821442189&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of food composition data by governments.
AU - Vanderveen, J. E.
AU - Pennington, J. A. T.
JO - Food and Nutrition Bulletin
JF - Food and Nutrition Bulletin
Y1 - 1983///
VL - 5
IS - 2
SP - 40
EP - 45
SN - 0379-5721
AD - Vanderveen, J. E.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19841458556. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Subject Subsets: Human Nutrition
KW - Food composition
KW - information
KW - reviews
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Nutrition (General) (VV100)
KW - Food Composition and Quality (QQ500)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841458556&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The occurrence of Psorophora cingulata and Uranotaenia apicalis in Guatemala (Diptera, Culicidae).
AU - Darsie, R. F., Jr.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1983///
VL - 15
IS - 1
SP - 28
EP - 32
SN - 0091-3669
AD - Darsie, R. F., Jr.: Medical Entomology Research and Training Unit/Guatemala, Center for Infectious Diseases, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19830504051. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The presence of Psorophora cingulata (F.) in Guatemala, which was recorded for the 1st time in 1956 when 2 females were collected, was confirmed by the capture of 5 further females, 1 with an aspirator in a cowshed and 4 in light-traps in forests. Uranotaenia apicalis Theo., which was known in Honduras and Panama (Central America), is recorded for the 1st time in Guatemala. Keys to the 4th-instar larvae and adult females of P. cingulata and U. apicalis (as compared with related species), are given.
KW - cattle housing
KW - distribution
KW - forests
KW - habitats
KW - mosquito nets
KW - Guatemala
KW - Honduras
KW - Panama
KW - Culicidae
KW - Diptera
KW - Psorophora cingulata
KW - Uranotaenia apicalis
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Psorophora
KW - Culicidae
KW - Uranotaenia
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Threshold Countries
KW - cattle sheds
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Husbandry (General) (LL100) (Discontinued March 2000)
KW - Other Control Measures (HH700)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830504051&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A comparative study of esterases in two strains of anopheline mosquitoes by isoelectric focusing.
AU - Miller, S.
AU - Novak, R.
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
Y1 - 1983///
VL - 15
IS - 12
SP - 1409
EP - 1415
SN - 0020-711X
AD - Miller, S.: Control Technology Branch, Division of Parasitic Diseases, Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19850525940. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 311-45-5. Subject Subsets: Medical & Veterinary Entomology
N2 - The multiple forms of esterases from 2 strains of Anopheles albimanus (from Panama and from Colombia (Papayal strain)) were separated by polyacrylamide isoelectric focusing; isoelectric points of the allelic bands were estimated. Analyses of esterases from single individuals showed a high degree of heterogeneity. The frequency of a dense band of esterolytic activity was distinctly different in the 2 geographically distinct strains. Five different types of esterases were tentatively identified. Most of the esterase activity was sensitive to paraoxon.
KW - distribution
KW - Enzymes
KW - esterases
KW - inhibition
KW - mosquito nets
KW - Paraoxon
KW - polymorphism
KW - toxicity
KW - Colombia
KW - Panama
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Central America
KW - Threshold Countries
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850525940&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal activity and Colorado tick fever virus infection rates in Rocky Mountain wood ticks, Dermacentor andersoni (Acari: Ixodidae), in north-central Colorado, USA.
AU - Eads, R. B.
AU - Smith, G. C.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1983///
VL - 20
IS - 1
SP - 49
EP - 55
SN - 0022-2585
AD - Eads, R. B.: Vector-Borne Diseases Division, Center for Infectious Diseases, Public Health Service, US Department of Health and Human Services, Fort Collins, Colorado 80522-2087, USA.
N1 - Accession Number: 19830502834. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 124-38-9. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Seasonal activity of adults of Dermacentor andersoni Stiles was studied in Larimer County, Colorado, in the summers of 1979 and 1980, by means of 25 platform traps baited with carbon dioxide. Ticks were marked with a spot of fluorescent paint (a different colour for each month), and 11% of them were recaptured in the following summer. By using the Lincoln index to determine population density, a density of 1139 ticks/ha was estimated for May 1979. In both years, tick activity began in early March, peaked in late April and ceased by the end of June. It was found that 12.9% of the marked ticks that had spent at least 2 winters in hibernation were infected by the Colorado tick fever virus, which indicated that ticks that became infected as larvae or nymphs retained the virus for extended periods.
KW - arboviruses
KW - attractants
KW - carbon dioxide
KW - disease vectors
KW - distribution
KW - infections
KW - seasonal variation
KW - traps
KW - vectors
KW - viral diseases
KW - Colorado
KW - North America
KW - USA
KW - Acari
KW - Colorado tick fever virus
KW - Dermacentor
KW - Dermacentor andersoni
KW - Metastigmata
KW - viruses
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Dermacentor
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - andersoni
KW - arthropod-borne viruses
KW - platform traps
KW - seasonal changes
KW - seasonal fluctuations
KW - tick activity
KW - United States of America
KW - viral infections
KW - Animal Behaviour (LL300)
KW - Economics (General) (EE100) (Discontinued June 2002)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830502834&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differentiation of host-seeking behavior from blood-feeding behavior in overwintering Culex pipiens (Diptera: Culicidae) and observations on gonotrophic dissociation.
AU - Mitchell, C. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1983///
VL - 20
IS - 2
SP - 157
EP - 163
SN - 0022-2585
AD - Mitchell, C. J.: Vector-Borne Diseases Division, Centres for Infectious Diseases, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19830504749. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Host-seeking was differentiated from blood-feeding behaviour in females of Culex pipiens L. overwintering in the laboratory in Colorado, USA, by comparing engorgement rates in mosquitoes given access to a host in small chambers (in which contact was inevitable) and large chambers (in which host-seeking behaviour was necessary before contact occurred). Blood-feeding by diapausing mosquitoes was rare at photophases simulating those of late summer or early autumn (even at temperatures up to 25 deg C) unless the mosquitoes were placed near a host, when some females were induced to feed; a proportion of these underwent gonotrophic dissociation when kept at 15 deg C and a short photophase during the digestion of the blood-meal. Such feeding followed by gonotrophic dissociation cannot however be assumed to occur in the field.
KW - behaviour
KW - feeding behaviour
KW - mosquito nets
KW - Colorado
KW - USA
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - behavior
KW - feeding behavior
KW - host seeking
KW - mosquitoes
KW - United States of America
KW - Animal Behaviour (LL300)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830504749&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variation in infectivity of Saint Louis encephalitis viral strains for Culex pipiens quinquefasciatus (Diptera: Culicidae).
AU - Mitchell, C. J.
AU - Gubler, D. J.
AU - Monath, T. P.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1983///
VL - 20
IS - 5
SP - 526
EP - 533
SN - 0022-2585
AD - Mitchell, C. J.: Division of Insect-Borne Viral Diseases, Centers for Disease Control, US Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19842008209. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Only 6 isolations of Saint Louis encephalitis (SLE) virus have been made from Argentina. These include 2 from patients with undifferentiated fever, 2 from rodents (CorAn-9124 and CorAn-9275), and 2 from mosquitoes (78V-6507 and 79V-2533). The infectivity of the last 4 strains for colonized Culex pipiens quinquefasciatus from Argentina was determined following intrathoracic inoculation of virus or by feeding mosquitoes on virus-laden suspensions. Comparison of the replication and dissemination of viral strains CorAn-9275 and 79V-2533 was made by serially dissecting orally infected mosquitoes and by testing heads, alimentary tracts, and body remnants separately. Each of the 4 viral strains replicated to high titer in Cx. p. quinquefasciatus following intrathoracic inoculation; however, day-20 infection rates never exceeded 5.1% in groups of mosquitoes fed on suspensions of CorAn-9124 and CorAn-9275. In contrast, infection rates were 90.9 and 87.5% in mosquitoes fed on suspensions of 78V-6507 and 79V-2533, and oral ID50's were 103.5 and 102.9 Vero cell PFU, respectively. Further, CorAn-9275 did not replicate well in Cx. p. quinquefasciatus alimentary tracts (avg. titers 102.1 and 102.5 PFU/ml on days 10 and 13) and rarely passed the mesenteronal barrier. In contrast, 79V-2533 readily infected mosquitoes by the oral route, replicated to high titer (avg. 104.8 PFU/ml) in the alimentary tract, and began disseminating by day 5. Widespread dissemination of virus occurred by day 10 but virus spread and multiplication continued at least through day 13, by which time viral antigen was detectable in head squashes of practically all mosquitoes tested. The infectivity of the 4 viral strains for Cx. p. quinquefasciatus correlates well with published reports on the virulence characteristics of these viral strains in vertebrates.AS<new para>ADDITIONAL ABSTRACT:<new para>Only 6 isolations of St. Louis encephalitis virus have been made in Argentina, 2 from fever patients, 2 from rodents and 2 from mosquitoes. The infectivity of the last 4 strains to a colony of Culex quinquesfasciatus Say (pipiens quinquefasciatus) originating from Argentina was determined in the USA by intrathoracic inoculation of the virus or by oral administration of virus-laden suspensions. Each of the 4 strains replicated to a high titre in the mosquitoes following intrathoracic inoculation; of the strains administered orally, 2 gave infection rates of over 85%, but the other 2 gave 5.1% or less, and one of them was found not to replicate well in the alimentary tract of C. quinquefasciatus. The infectivity of the 4 viral strains for C. quinquefasciatus correlated well with published reports on their relative virulence in vertebrates.
KW - arboviruses
KW - disease vectors
KW - encephalitis
KW - mosquito nets
KW - replication
KW - strain differences
KW - vectors
KW - viral diseases
KW - Argentina
KW - USA
KW - Culex quinquefasciatus
KW - Culicidae
KW - Diptera
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - arthropod-borne viruses
KW - encephalomyelitis
KW - mosquitoes
KW - United States of America
KW - variation in infectivity of strains
KW - viral infections
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842008209&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary protein and lecithin on plasma and liver lipids and plasma lipoproteins in rats.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
AU - Vanderveen, J. E.
AU - Adkins, J. S.
AU - Edwards, C. H.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1983///
VL - 28
IS - 3
SP - 621
EP - 634
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19841454021. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Soyabeans
N2 - The interrelationships among protein source (lactalbumin, collagen, soya protein concentrate, wheat gluten), protein type (animal, plant), and level of lecithin (0, 2.5, 5.0%) were studied. Male weanling Sprague-Dawley rats were fed on purified 10% protein diets for 28 days. Soya bean lecithin was the principal source of dietary choline. For all protein sources except wheat gluten, liver weight (expressed as per cent of bodyweight) decreased when lecithin was added to the diet. Soya bean lecithin reduced liver triglyceride and cholesterol concentrations in rats fed on all protein sources. Rats given animal protein had lower liver triglyceride and cholesterol than had rats given plant proteins with lecithin 2.5 and 5.0%. Rats given animal protein had higher plasma cholesterol and liver protein concentrations than rats given plant proteins with lecithin 5.0%. Protein source but not lecithin level influenced high-density lipoprotein values.
KW - blood
KW - blood lipids
KW - cholesterol
KW - concentrates
KW - feeds
KW - lipids
KW - lipoproteins
KW - liver
KW - phosphatidylcholines
KW - plant proteins
KW - Protein intake
KW - Protein sources
KW - soyabeans
KW - supplements
KW - Glycine (Fabaceae)
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - feeding stuffs
KW - lecithins
KW - lipins
KW - protein feeds
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (General) (LL500)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841454021&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of excess L-lysine on rat growth and on plasma and tissue concentrations of copper, iron and zinc.
AU - Mitchell, G. V.
AU - Jenkins, M. Y.
JO - Journal of Nutritional Science and Vitaminology
JF - Journal of Nutritional Science and Vitaminology
Y1 - 1983///
VL - 29
IS - 5
SP - 709
EP - 715
SN - 0301-4800
AD - Mitchell, G. V.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19841460210. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7440-50-8, 7439-89-6, 56-87-1, 7440-66-6. Subject Subsets: Human Nutrition
N2 - From 22 days old male Sprague-Dawley rats were given a diet with 10% casein without or with excess lysine. There was no significant difference in bodyweight gain, food intake or plasma proteins among the groups. Supplementation of the basal diet with 21% L-lysine caused a 53% decrease in copper in liver and a smaller decrease in iron. Addition of 0.7 or 2.1% lysine to the basal diet caused significant decreases in plasma Cu. Zinc in plasma decreased with 2.1% lysine in the diet.
KW - blood
KW - Copper
KW - growth
KW - Iron
KW - liver
KW - loads
KW - Lysine
KW - minerals
KW - Zinc
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841460210&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elements in major raw agricultural crops in the United States. 1. Cadmium and lead in lettuce, peanuts, potatoes, soybeans, sweet corn, and wheat.
AU - Wolnik, K. A.
AU - Fricke, F. L.
AU - Capar, S. G.
AU - Braude, G. L.
AU - Meyer, M. W.
AU - Satzger, R. D.
AU - Bonnin, E.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1983///
VL - 31
IS - 6
SP - 1240
EP - 1244
SN - 0021-8561
AD - Wolnik, K. A.: Food and Drug Administration, Cincinnati, Ohio 45202, USA.
N1 - Accession Number: 19840318814. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Horticultural Science; Crop Physiology; Soils & Fertilizers; Potatoes; Soyabeans; Field Crops; Human Nutrition; Wheat, Barley & Triticale Abstracts
N2 - Six raw agricultural crops, collected from major US growing areas uncontaminated by human activities other than normal agricultural practices, were analysed for Cd and Pb by using differential pulse anodic stripping voltammetry. Mean concentrations of Pb and Cd (μg/g wet weight) were, for lettuce, 0.013 and 0.026, for peanuts, 0.10 and 0.078, for potatoes, 0.009 and 0.031, for soyabeans, 0.042 and 0.059, for sweet corn, 0.0033 and 0.0031, and for wheat, 0.037 and 0.043, respectively.
KW - Cadmium
KW - composition
KW - field crops
KW - Groundnuts
KW - Lead
KW - Lettuces
KW - maize
KW - Maps
KW - oilseed plants
KW - plant composition
KW - plant products
KW - pollution
KW - Potatoes
KW - research
KW - Soyabeans
KW - Sweetcorn
KW - uptake
KW - vegetables
KW - Wheat
KW - USA
KW - Arachis hypogaea
KW - Asteraceae
KW - Glycine (Fabaceae)
KW - Lactuca sativa
KW - plants
KW - Solanum tuberosum
KW - Triticum
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Asterales
KW - Lactuca
KW - Asteraceae
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - Zea
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Accumulation
KW - Cadium
KW - chemical constituents of plants
KW - corn
KW - crop products
KW - environmental pollution
KW - oilseed crops
KW - peanuts
KW - soybeans
KW - studies
KW - United States of America
KW - vegetable crops
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Pollution and Degradation (PP600)
KW - Plant Composition (FF040)
KW - Plant Physiology and Biochemistry (FF060)
KW - Plant Nutrition (FF061)
KW - Fertilizers and other Amendments (JJ700)
KW - Plant Science (General) (FF000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840318814&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elements in major raw agricultural crops in the United States. 2. Other elements in lettuce, peanuts, potatoes, soybeans, sweet corn, and wheat.
AU - Wolnik, K. A.
AU - Fricke, F. L.
AU - Capar, S. G.
AU - Braude, G. L.
AU - Meyer, M. W.
AU - Satzger, R. D.
AU - Kuennen, R. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1983///
VL - 31
IS - 6
SP - 1244
EP - 1249
SN - 0021-8561
AD - Wolnik, K. A.: Food and Drug Administration, Cincinnati, Ohio 45202, USA.
N1 - Accession Number: 19840318815. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7440-70-2, 7440-50-8, 7439-89-6, 7439-96-5, 7439-95-4, 7439-98-7, 7440-02-0, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6. Subject Subsets: Horticultural Science; Crop Physiology; Potatoes; Soyabeans; Field Crops; Human Nutrition; Wheat, Barley & Triticale Abstracts; Soils & Fertilizers; Soils & Fertilizers
N2 - Six raw agricultural crops from fields in major US growing areas were analysed for Ca, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, P, Se and Zn. Statistical frequency distributions of some of the major elements (Ca, K and P) and for Fe and Mg, were normal.
KW - Calcium
KW - composition
KW - Copper
KW - field crops
KW - groundnuts
KW - Iron
KW - lettuces
KW - Magnesium
KW - maize
KW - Manganese
KW - Minerals
KW - Molybdenum
KW - Nickel
KW - nutrients
KW - NUTRITIVE VALUE
KW - oilseed plants
KW - Phosphorus
KW - plant composition
KW - plant products
KW - Potassium
KW - Potatoes
KW - Selenium
KW - Sodium
KW - Soyabeans
KW - Sweetcorn
KW - trace elements
KW - uptake
KW - vegetables
KW - Wheat
KW - Zinc
KW - USA
KW - Arachis hypogaea
KW - Asteraceae
KW - Glycine (Fabaceae)
KW - Lactuca sativa
KW - plants
KW - Solanum tuberosum
KW - Triticum
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Asterales
KW - Lactuca
KW - Asteraceae
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - Zea
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Accumulation
KW - chemical constituents of plants
KW - corn
KW - crop products
KW - microelements
KW - Mn
KW - Mo
KW - nutritional value
KW - oilseed crops
KW - peanuts
KW - quality for nutrition
KW - soybeans
KW - United States of America
KW - vegetable crops
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Plant Composition (FF040)
KW - Plant Physiology and Biochemistry (FF060)
KW - Plant Nutrition (FF061)
KW - Fertilizers and other Amendments (JJ700)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Animal Science (General) (LL000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840318815&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of New Guama and Group C serogroup bunyaviruses and an ungrouped virus from southern Brazil.
AU - Calisher, C. H.
AU - Coimbra, T. L. M.
AU - Lopes, O. de Souza
AU - Muth, D. J.
AU - Sacchetta, L. de Abreu
AU - Francy, D. B.
AU - Lazuick, J. S.
AU - Cropp, C. B.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1983///
VL - 32
IS - 2
SP - 424
EP - 431
SN - 0002-9637
AD - Calisher, C. H.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19830504596. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - From 1975 to 1978, 36 viruses were recovered from man, bats, birds, sentinel mice and hamsters, and from Culex sacchettae Sirivanakarn & Jakob, C. taeniopus D. & K. and C. epanastasis Dyar, all of the subgenus Melanoconion, collected in coastal Brazil in the State of Sao Paulo. Identifications of 22 of these 36 viruses have been reported. Six of the remaining 14 isolates were shown to be Guama serogroup bunyaviruses. Two of these 6were strains of a newly recognised virus for which the name Cananeia virus is proposed; another is a second newly recognised Guama serogroup virus for which the name Itimirim virus is proposed; a fourth is a strain of Bertioga virus and the other 2 are strains of Guaratuba virus. Before these studies Guaratuba virus was considered an ungrouped bunyavirus, but cross-testing by complement-fixation demonstrated that this virus, and Mirim virus as well, should be considered members of the Guama serogroup. Another 6 viruses were shown to be strains of a single, newly recognised Group C bunyavirus for which the name Bruconha virus is proposed. Two strains of a single virus were shown by electron microscopy to belong to the family Bunyaviridae, but serological relationships with other members of this family of viruses were not found; the name Enseada virus is proposed for this newly recognised agent.
KW - disease vectors
KW - distribution
KW - hosts
KW - mosquito nets
KW - vectors
KW - Brazil
KW - Bertioga virus
KW - Culex taeniopus
KW - Culicidae
KW - Diptera
KW - Oryzomys
KW - viruses
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Sigmodontinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Bruconha virus
KW - Cananeia virus
KW - Culex epanastasis
KW - Culex sachettae
KW - Enseada virus
KW - Guaratuba virus
KW - Itimirim virus
KW - mosquitoes
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830504596&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cadmium bioavailability.
AU - Fox, M. R. S.
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1983///
VL - 42
IS - 6
SP - 1726
EP - 1729
SN - 0014-9446
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Dep. Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19831447459. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
KW - availability
KW - cadmium
KW - reviews
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831447459&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biotoxicity of lead: influence of various factors.
AU - Mahaffey, K. R.
JO - Federation Proceedings
JF - Federation Proceedings
Y1 - 1983///
VL - 42
IS - 6
SP - 1730
EP - 1734
SN - 0014-9446
AD - Mahaffey, K. R.: Division of Nutrition, Food and Drug Administration, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19831447460. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
KW - lead
KW - reviews
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831447460&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of vitamin E and ICRF-187 on chronic doxorubicin cardiotoxicity in miniature swine.
AU - Herman, E. H.
AU - Ferrans, V. J.
JO - Laboratory Investigation
JF - Laboratory Investigation
Y1 - 1983///
VL - 49
IS - 1
SP - 69
EP - 77
SN - 0023-6837
AD - Herman, E. H.: Division of Drug Biology, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19841453651. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 23214-92-8, 1406-18-4. Subject Subsets: Human Nutrition; Pig Science
N2 - Miniature pigs weighing 19 to 40 kg were given 6 injections of doxorubicin, 1.6 mg/kg at 3-week intervals (total dose, 9.6 mg/kg), alone or concurrently with vitamin E, 5000 IU daily for 4 days and 1000 units daily for the next 17 days. In a second study, miniature pigs received 6 injections of doxorubicin, 2.4 mg/kg at 3-week intervals (total dose 14.4 mg/kg), alone or 30 min after ICRF-187, 12.5 mg/kg intraperitoneally. All the pigs were killed 3 weeks after the last injection. The frequency and extent of myocardial lesions (vacuolization and myofibrillar loss) were scored on a scale of 0 to 4+. Such lesions were noted in 8 of 9 pigs given doxorubicin 9.6 mg/kg alone and in all pigs receiving doxorubicin and vitamin E; however, the severity of the lesions was decreased in the latter pigs (average score 1.0, compared with 1.8 in those receiving doxorubicin alone). All pigs receiving doxorubicin 14.4 mg/kg alone developed myocardial lesions (average score, 2.7); those lesions were severe (3+) in 4 of the pigs. Cardiac lesions were absent in 2 and slight (average score, 0.7) in 5 of the 7 pigs given doxorubicin 14.4 mg/kg in combination with ICRF-187.
KW - administration
KW - Doxorubicin
KW - heart
KW - miniature pigs
KW - RESEARCH
KW - toxicity
KW - vitamin E
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adriamycin
KW - hogs
KW - Miniature pig
KW - minipigs
KW - studies
KW - swine
KW - Physiology of Human Nutrition (VV120)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841453651&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Habitat differences among container-breeding mosquitoes in western Puerto Rico (Diptera: Culicidae).
AU - Moore, C. G.
JO - Pan-Pacific Entomologist
JF - Pan-Pacific Entomologist
Y1 - 1983///
VL - 59
IS - 1/4
SP - 218
EP - 228
SN - 0031-0603
AD - Moore, C. G.: US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522-2087, USA.
N1 - Accession Number: 19850520858. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Surveys carried out January-June 1971, the results of which are described and discussed in detail, provided no evidence of behavioural changes in populations of Aedes aegypti in western Puerto Rico as a result of the programme to eradicate the mosquito. More than 99% of all collections yielding this species were made at distances of less than 85 m from the nearest house, and no examples of A. aegypti were taken more than 100 m from houses. Natural container breeding sites made up only 17% of the total. A highly negative association between this mosquito and the other major container-breeding species suggests that if competitive displacement occurred, it did so some time ago.
KW - distribution
KW - habitats
KW - mosquito nets
KW - water containers
KW - Puerto Rico
KW - Aedes aegypti
KW - Culicidae
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - mosquitoes
KW - Porto Rico
KW - Other Control Measures (HH700)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850520858&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas-liquid chromatographic screening method for determination of methyl mercury in tuna and swordfish.
AU - James, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1983///
VL - 66
IS - 1
SP - 128
EP - 129
AD - James, T.: Food and Drug Administration, 1521 W Pico Blvd, Los Angeles, CA 90015, USA.
N1 - Accession Number: 19831445535. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 593-74-8. Subject Subsets: Human Nutrition
KW - estimation
KW - methylmercury
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831445535&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of copper, nickel, and chromium in foods.
AU - Holak, W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1983///
VL - 66
IS - 3
SP - 620
EP - 624
AD - Holak, W.: Food and Drug Administration, 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19831450411. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 7440-47-3, 7440-50-8, 7440-02-0. Subject Subsets: Human Nutrition
N2 - A collaborative study to estimate 5 elements in food (NAR/A 51, 732) is extended to include copper, nickel and chromium. Cu is estimated by atomic absorption spectrophotometry or anodic stripping voltammetry, Ni and Cr by differential pulse polarography. The sensitivity is 0.34, 0.14 and 0.24 mu g/g, respectively.
KW - chromium
KW - copper
KW - estimation
KW - nickel
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831450411&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and estimation of the alkaloids of Rauwolfia serpentina by high performance liquid chromatography and thin layer chromatography.
AU - Cieri, U. R.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1983///
VL - 66
IS - 4
SP - 867
EP - 873
AD - Cieri, U. R.: Food and Drug Administration, Philadelphia, PA 19106, USA.
N1 - Accession Number: 19830316106. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 50-55-5, 12168-92-2, 146-48-5. Subject Subsets: Horticultural Science
N2 - Alkaloids detected in R. [Rauvolfia] serpentina were rescinnamate, reserpine, raubasinine, ajmalicine, yohimbine, ajmaline and serpentine.
KW - alkaloids
KW - determination
KW - medicinal plants
KW - plant composition
KW - Reserpine
KW - Serpentine
KW - Yohimbine
KW - Rauvolfia serpentina
KW - Rauvolfia
KW - Apocynaceae
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Ajmalicine
KW - Ajmaline
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Raubasinine
KW - Rescinnamate
KW - Plant Science (General) (FF000)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19830316106&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mixed acid solubilization procedure for determination of total mercury in food samples.
AU - Marts, R. W.
AU - Blaha, J. J.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1983///
VL - 66
IS - 6
SP - 1421
EP - 1423
AD - Marts, R. W.: Food and Drug Administration, 1009 Cherry St., Kansas City, MO 64106, USA.
N1 - Accession Number: 19841456300. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7439-97-6. Subject Subsets: Human Nutrition
KW - estimation
KW - foods
KW - Mercury
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841456300&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on the Indochina I/CDC strain of Plasmodium falciparum in Colombian and Bolivian Aotus monkeys and different anophelines.
AU - Collins, W. E.
AU - Campbell, C. C.
AU - Skinner, J. C.
AU - Chin, W.
AU - Nguyen-Dinh, P.
AU - Huong, A. Y.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1983///
VL - 69
IS - 1
SP - 186
EP - 190
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19842016915. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Protozoology
N2 - The Indochina I/CDC strain of Plasmodium falciparum was isolated from a physician returning to the United States after working in the refugee camps along the Thailand-Kampuchean border. The strain was established in splenectomized Aotus monkeys from Colombia after being grown in vitro for 50 days. During the first three passages in Colombian monkeys, the parasites were not infective to Bolivian Aotus monkeys. After six intervening passages in Saimiri sciureus monkeys, the parasites produced high parasitemias in both Colombian and Bolivian Aotus, but gametocytes were no longer produced. Mosquito infections were obtained only during the first three passages in the Colombian monkeys. The most susceptible mosquito was Anopheles freeborni, followed by An. dirus, An. stephensi, An. maculatus, An. culicifacies, and, rarely, An. gambiae. Sporozoites were found in the salivary glands of the An. freeborni, An. dirus, An. stephensi, and An. maculatus.AS<new para>ADDITIONAL ABSTRACT:<new para>A strain of Plasmodium falciparum (Indochina I/CDC) was isolated from a physician returning to the USA after working on the border between Thailand and Kampuchea and was established in splenectomised monkeys (Aotus) from Colombia. During the first 3 passages in these monkeys, the parasite was not infective to Aotus from Bolivia. After 6 intervening passages in monkeys of a different genus (Saimiri sciureus), the parasites produced high parasitaemias in Aotus both Colombia and Bolivia, but gametocytes were no longer produced. Infections in mosquitoes were obtained only during the first 3 passages in the Colombian monkeys. The most susceptible species was Anopheles freeborni Aitken, followed by A. dirus Peyton & Harrison, A. stephensi List., A. maculatus Theo., A. culicifacies Giles and, rarely, A. gambiae Giles. Sporozoites were found in the salivary glands of females of A. freeborni, A. dirus, A. stephensi and A. maculatus.
KW - animal models
KW - disease vectors
KW - experimental infection
KW - experimental infections
KW - hosts
KW - infectivity
KW - malaria
KW - mosquito nets
KW - parasites
KW - vectors
KW - Bolivia
KW - Cambodia
KW - Colombia
KW - Thailand
KW - USA
KW - Anopheles
KW - Anopheles culicifacies
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles maculatus
KW - Anopheles stephensi
KW - Aotus
KW - Aotus trivirgatus
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - insects
KW - monkeys
KW - Plasmodium falciparum
KW - Primates
KW - protozoa
KW - Saimiri sciureus
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Aotus
KW - Protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Saimiri
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Indochina
KW - South East Asia
KW - Asia
KW - Least Developed Countries
KW - APEC countries
KW - ASEAN Countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - experimental transmission
KW - infectivity of Indochina strain
KW - Kampuchea
KW - Khmer Republic
KW - mosquitoes
KW - United States of America
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842016915&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Revision of the Total Diet Study food list and diets.
AU - Pennington, J. A. T.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1983///
VL - 82
IS - 2
SP - 166
EP - 173
SN - 0002-8223
AD - Pennington, J. A. T.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19831447453. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition
N2 - The Total Diet Study is an annual programme operated by the USA Food and Drug Administration. Essential minerals and toxic or radioactive constituents are estimated in foods bought in shops throughout the USA. A revised basis for the selection of foods and diets for the programme is described.
KW - diet studies
KW - nutrient requirements
KW - nutrition programmes
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dietary standards
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - food requirements
KW - nutrition programs
KW - nutritional requirements
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831447453&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total diet study: determination of iodine intake by neutron activation analysis.
AU - Allegrini, M.
AU - Pennington, J. A. T.
AU - Tanner, J. T.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1983///
VL - 83
IS - 1
SP - 18
EP - 24
SN - 0002-8223
AD - Allegrini, M.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19841452300. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition
N2 - Iodine was estimated in 12 groups of foods in 20 diets for adults and in 11 groups of foods in 10 diets for infants and 10 for young children in USA in 3 fiscal years between 1974 and 1980. Total daily intake of iodine for adults ranged from 268 to 1212 μg, based on energy intake of 3900 kcal, or from 199 to 901 μg based on 2900 kcal; the range corresponding to 2900 kcal was 133 to 601% of the recommended dietary allowance (RDA) of 150 μg. Intake was for infants 231 to 621 μg, or 308 to 1380% of the RDA, which was taken to be an average of 45 μg for infants 6 months old. It was for young children 190 to 670 μg, or 271 to 957% of the RDA of 70 μg daily. Results did not include iodized salt added by the consumer.
KW - Diet study techniques
KW - intake
KW - Iodine
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841452300&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietetics training for American Indians and Alaskan natives.
AU - Jackson, M. Y.
AU - Cornelius, M. S.
AU - Johnson, C. I.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1983///
VL - 83
IS - 1
SP - 48
EP - 50
SN - 0002-8223
AD - Jackson, M. Y.: Nutrition and Dietetics Training Center, Indian Health Service, Santa Fe, N.Mex., USA.
N1 - Accession Number: 19841452323. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition
KW - Ethnic groups
KW - nutrition education
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841452323&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Annoyance by the predaceous bug, Reduvius personatus (L.) (Hemiptera: Reduviidae), in north central Colorado.
AU - Eads, R. B.
AU - Campos, E. G.
JO - Proceedings of the Entomological Society of Washington
JF - Proceedings of the Entomological Society of Washington
Y1 - 1983///
VL - 85
IS - 4
SP - 853
EP - 854
SN - 0013-8797
AD - Eads, R. B.: Division of Vector-Borne Viral Diseases, Centres for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19840510826. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Entomology; Biocontrol
N2 - Accounts are discussed of bites on man by predacious reduviids, especially Reduvius personatus (L.) in central Colorado, which normally preys on Oeciacus vicarius Horv. and other ectoparasites of the cliff swallow (Petrochelidon pyrrhonota); O. vicarius also occasionally attacks man near swallow nesting sites. Attention is drawn to the unusually high numbers of R. personatus (although not of O. vicarius) in Colorado in 1981. The removal of cliff swallow nests and insecticide treatment of the immediate area are suggested as a possible means of reducing annoyance from Reduvius populations, although the adults are strong fliers and some would probably disperse into urban areas.
KW - bites
KW - distribution
KW - hosts
KW - insect bites
KW - Natural enemies
KW - predators
KW - prey
KW - Colorado
KW - USA
KW - arthropods
KW - Hemiptera
KW - Hirundo
KW - Hirundo pyrrhonota
KW - man
KW - Oeciacus vicarius
KW - Reduviidae
KW - Reduvius personatus
KW - invertebrates
KW - animals
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - Hirundo
KW - Hirundinidae
KW - Passeriformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Heteroptera
KW - Hemiptera
KW - Reduvius
KW - Reduviinae
KW - Reduviidae
KW - Oeciacus
KW - Cimicidae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Petrochelidon
KW - Petrochelidon pyrrhonota
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Control (HH100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840510826&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tinea capitis in the New York City area.
AU - Ravits, M. S.
AU - Himmelstein, R.
JO - Archives of Dermatology
JF - Archives of Dermatology
Y1 - 1983///
VL - 119
IS - 6
SP - 532
EP - 533
SN - 0003-987X
AD - Ravits, M. S.: US Public Health Service Hosp., Staten Island, NY, USA.
N1 - Accession Number: 19831392154. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A consecutive series of 31 patients with tinea capitis seen during 1976-81 is reported. In each case, Trichophyton tonsurans was the causative agent. Patients were treated successfully with griseofulvin, miconazole or clotrimazole.
KW - Dermatophytes
KW - hosts
KW - infection
KW - scalp
KW - USA
KW - Arthrodermataceae
KW - man
KW - Onygenales
KW - Trichophyton tonsurans
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Trichophyton
KW - Arthrodermataceae
KW - Onygenales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungus
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831392154&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary zinc, manganese, and copper on tissue accumulation of cadmium by Japanese quail.
AU - Jacobs, R. M.
AU - Jones, A. O. L.
AU - Fox, M. R. S.
AU - Lener, J.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1983///
VL - 172
IS - 1
SP - 34
EP - 38
SN - 0037-9727
AD - Jacobs, R. M.: Division of Nutrition, Food and Drug Administration, HFF-268, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19831446221. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7440-43-9, 7440-50-8, 7439-96-5, 7440-66-6. Subject Subsets: Human Nutrition
N2 - The beneficial effects of a combined dietary supplement of Zn, Cu, and Mn in decreasing Cd absorption was previously reported. In 2 studies day-old quail were given basal diets containing either the required amounts of Zn (30 mu g/g) and Mn (12 mu g/g) and slightly above requirement amounts of Cu (5 mu g/g). From day 7 birds were fed either the basal diet or diets containing combinations at twice these concentrations; 109Cd content and Cd concentration of these diets were 100 mu Ci and 145 mu g/kg, respectively. In the 3rd experiment, birds were fed on the basal diet or a basal diet containing 109Cd and single additional supplements of Zn, Cu, or Mn. All birds were killed at 14 days of age. When the diets were given for 7 days, only Zn had a protective effect against Cd. Whereas none of the elements reduced the Cd concentration of the duodenum, Zn decreased Cd in the jejunum-ileum, liver, and kidney by about 66, 21, and 11%, respectively. Cu and Mn caused occasional increases of Cd in some tissues. There were similar responses with diets given for 2 weeks. Zn nutrition appears to be important in protecting against dietary Cd absorption.
KW - absorption
KW - cadmium
KW - copper
KW - manganese
KW - poultry
KW - supplements
KW - zinc
KW - Japanese quails
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - domesticated birds
KW - Mn
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19831446221&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vertical transmission of spotted fever group and scrub typhus rickettsiae.
AU - Burgdorfer, W.
JO - Current Topics in Vector Research
JF - Current Topics in Vector Research
Y1 - 1984///
VL - 2
SP - 77
EP - 92
CY - New York; USA
PB - Praeger Publishers
SN - 003071611X
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Epidemiology Branch, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19920512059. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This review examines transovarian transmission of Rickettsia rickettsii and other spotted fever group (SFG) rickettsiae, venereal transmission of SFG rickettsiae, and transovarian transmission of R. tsutsugamushi.
KW - disease vectors
KW - Reviews
KW - Sexual transmission
KW - Transovarial transmission
KW - vertical transmission
KW - Acari
KW - Ixodidae
KW - Orientia tsutsugamushi
KW - Rickettsia
KW - Rickettsia rickettsii
KW - Rickettsiaceae
KW - Trombiculidae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Metastigmata
KW - Acari
KW - Orientia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Rickettsia
KW - Prostigmata
KW - mites
KW - bacterium
KW - Rickettsia tsutsugamushi
KW - venereal transmission
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920512059&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Carcinogens and mutagens present as natural components of food or induced by cooking.
AU - Prival, M. J.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1984///
VL - 6
IS - 4
SP - 236
EP - 253
SN - 0163-5581
AD - Prival, M. J.: Genetic Toxicology Branch (HFF-166), Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19851474788. Publication Type: Journal Article. Language: English. Number of References: 107 ref. Subject Subsets: Human Nutrition
KW - carcinogens
KW - Foods
KW - mutagens
KW - reviews
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851474788&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ecological management of malaria vectors.
AU - Hess, A. D.
JO - Bulletin of the Society of Vector Ecologists
JF - Bulletin of the Society of Vector Ecologists
Y1 - 1984///
VL - 9
IS - 1
SP - 23
EP - 26
AD - Hess, A. D.: US Public Health Service, Disease Ecology-Aquatic Biol., PO Box 660, La Porte, CO 80535, USA.
N1 - Accession Number: 19890593301. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Knowledge and techniques acquired before the widespread use of DDT have important applications in the development of modern day programmes for the control of malaria vectors. The following are briefly discussed in this general account: interrelationships with plants; water management; intersection values; forage ratios; zooprophylaxis; physical modifications; and the mutual interests of wildlife conservation and mosquito control. It is considered that vector ecologists have a major role to play in the development of future control programmes.
KW - control
KW - environmental management
KW - insect control
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - Environmental Pest Management (HH200)
KW - Natural Resources (General) (PP000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890593301&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The presence of Psorophora cilipes (Diptera, Culicidae) in Guatemala.
AU - Darsie, R. F., Jr.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1984///
VL - 16
IS - 2
SP - 141
EP - 143
SN - 0091-3669
AD - Darsie, R. F., Jr.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19840518276. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Psorophora cilipes (F.), which is known to bite man elsewhere in Central America, is recorded in Guatemala, where larvae were collected from temporary ground pools in a forested area where cattle were grazing. This record brings the total number of mosquito species known in Guatemala to 129.
KW - distribution
KW - mosquito nets
KW - Guatemala
KW - Culicidae
KW - Diptera
KW - Psorophora cilipes
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Psorophora
KW - Culicidae
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - mosquitoes
KW - Other Control Measures (HH700)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840518276&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The siphonal index. I. A method for evaluating Culex pipiens subspecies and intermediates.
AU - Brogdon, W. G.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1984///
VL - 16
IS - 2
SP - 144
EP - 152
SN - 0091-3669
AD - Brogdon, W. G.: Division of Parasitic Diseases, Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19840518277. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The siphonal index and the parameters used in its determination were compared in the laboratory in the USA for late fourth-instar larvae of Culex pipiens L. and C. quinquefasciatus Say (pipiens quinquefasciatus) (reference strains, field-collected intermediates and laboratory hybrids). The results indicated that C. pipiens could be distinguished from C. quinquefasciatus through measurements of siphonal length or width, but that more complete characterisation could be obtained by means of the siphonal index. Field-collected intermediates and laboratory hybrids could be distinguished by larval siphon width, and either intermediate type could be distinguished from C. pipiens or C. quinquefasciatus by siphon length or index but not by siphon width.
KW - characteristics
KW - identification
KW - mosquito nets
KW - taxonomy
KW - USA
KW - Culex pipiens
KW - Culex quinquefasciatus
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - mosquitoes
KW - systematics
KW - United States of America
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840518277&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The siphonal index. II. Relative abundance of Culex species, subspecies, and intermediates in Memphis, Tennessee.
AU - Brogdon, W. G.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1984///
VL - 16
IS - 2
SP - 153
EP - 161
SN - 0091-3669
AD - Brogdon, W. G.: Division of Parasitic Diseases, Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19840518278. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - As part of a study of Culex pipiens L. in Memphis, Tennessee, egg rafts of C. pipiens, C. restuans Theo. and C. salinarius Coq. were collected from widely distributed sites in 1979-80. Marked differences were observed between the breeding seasons of the 2 years, the pattern for 1980 resembling that of 1975, when an epidemic of St. Louis encephalitis occurred. Owing to the interseasonal variability in numbers of potential vectors of the virus, the monitoring of populations of Culex species and subspecies is suggested; the method of monitoring populations by collecting egg rafts from specific sites, rearing them to the larval stage and measuring siphonal indices of the larvae is recommended as being particularly cost-effective.
KW - distribution
KW - monitoring
KW - mosquito nets
KW - seasonal variation
KW - Tennessee
KW - USA
KW - Culex pipiens
KW - Culex restuans
KW - Culex salinarius
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - mosquitoes
KW - seasonal changes
KW - seasonal fluctuations
KW - surveillance systems
KW - United States of America
KW - Other Control Measures (HH700)
KW - Taxonomy and Evolution (ZZ380)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840518278&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental transmission of Rocio encephalitis virus by Aedes scapularis (Diptera: Culicidae) from the epidemic zone in Brazil.
AU - Mitchell, C. T.
AU - Forattini, O. P.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1984///
VL - 21
IS - 1
SP - 34
EP - 37
SN - 0022-2585
AD - Mitchell, C. T.: Division of Vector-Borne Viral Diseases, Centres for Disease Control, US Public Health Service, Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19840514914. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The first vector competence studies with mosquito strains from an area of epidemics of Rocio encephalitis in Brazil are reported. The F1 progeny of females of Aedes scapularis (Rond.) collected at Pariquera-Açu, Sã0 Paulo State, in May, November, December, January and February were all susceptible to oral infection with the virus. Mosquitoes fed on a chick circulating 107.5 PFU/ml virus achieved 100% infection and transmission, although infection rates were generally lower. The susceptibility of A. scapularis to oral infection, its ability to transmit the virus experimentally and its abundance and close association with man in the epidemic zone indicate that this species was probably the vector of Rocio virus during the epidemics at São Paulo in 1975 and 1976.
KW - disease transmission
KW - disease vectors
KW - distribution
KW - mosquito nets
KW - transmission
KW - vectors
KW - Brazil
KW - Aedes
KW - Aedes scapularis
KW - Culicidae
KW - Diptera
KW - Rocio virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus scapularis
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840514914&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human parasitism by Otobius megnini (Acari: Argasidae) in New Mexico, USA.
AU - Eads, R. B.
AU - Campos, E. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1984///
VL - 21
IS - 2
SP - 244
EP - 244
SN - 0022-2585
AD - Eads, R. B.: Division of Vector-Born Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19840516227. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Data are given on 7 cases of human infestation by nymphs of Otobius megnini (Dugès) near Gallup, New Mexico. The ticks gave little annoyance to their hosts during the extended period of larval and nymphal development. This species thus presents a potential health problem in rural areas, where people live in close association with domestic animals, since infestation could result in inner ear damage or in transmission of infectious disease agents before it was noticed and medical help sought.
KW - distribution
KW - hosts
KW - Infestation
KW - Tick infestations
KW - New Mexico
KW - North America
KW - USA
KW - Acari
KW - man
KW - Metastigmata
KW - Otobius megnini
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Acari
KW - Otobius
KW - Argasidae
KW - Metastigmata
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - ear tick
KW - ears in USA
KW - infestation of ears in USA
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840516227&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of steroid hormones in a human-serum reference material by isotope dilution-mass spectrometry: a candidate definitive method for cortisol.
AU - Patterson, D. G.
AU - Patterson, M. B.
AU - Culbreth, P. H.
AU - Fast, D. M.
AU - Holler, J. S.
AU - Sampson, E. J.
AU - Bayse, D. D.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1984///
VL - 30
IS - 5
SP - 619
EP - 626
SN - 0009-9147
AD - Patterson, D. G.: Clinical Chemistry Division, Center for Environmental Health, Centres for Disease Control, Public Health Service, Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19841460892. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 50-03-3, 50-23-7, 6000-74-4, 125-04-2, 13609-67-1. Subject Subsets: Human Nutrition
KW - blood
KW - estimation
KW - HYDROCORTISONE
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cortisol
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841460892&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of pesticide residues in foods by fluorine-19 Fourier transform nuclear magnetic resonance spectroscopy.
AU - Mazzola, E. P.
AU - Borsetti, A. P.
AU - Page, S. W.
AU - Bristol, D. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1984///
VL - 32
IS - 5
SP - 1102
EP - 1103
SN - 0021-8561
AD - Mazzola, E. P.: Div. of Chem. and Physics, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19850772685. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 1582-09-8. Subject Subsets: Weeds; Human Nutrition
N2 - Pesticide residues were accurately determined at or near tolerance levels in certain foods by fluorine-19 Fourier transform NMR spectroscopy. 19F NMR spectral data were obtained for a series of common chlorine-containing pesticides including a number of herbicides. Lower conc. limits for sample screening were also established for compounds containing the trifluoromethyl group. Usable spectra were obtained for trifluralin in selected, fortified crop extracts and in fish.
KW - analytical methods
KW - estimation
KW - Foods
KW - herbicides
KW - nuclear magnetic resonance
KW - pesticides
KW - plant residues
KW - residues
KW - toxicology
KW - Trifluralin
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - analytical techniques
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850772685&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue viruses.
AU - Gubler, D. J.
AU - Kuno, G.
AU - Sather, G. E.
AU - Velez, M.
AU - Oliver, A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1984///
VL - 33
IS - 1
SP - 158
EP - 165
SN - 0002-9637
AD - Gubler, D. J.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, San Juan, Puerto Rico 00936.
N1 - Accession Number: 19840514409. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - During the autumn of 1981, a new method for the routine isolation and identification of dengue viruses in Puerto Rico was implemented utilising C6/36 cultures of cells of Aedes albopictus (Skuse) and serotype specific antidengue monoclonal antibodies. A blind comparison of the monoclonal antibody indirect fluorescent antibody test (IFAT) and the complement fixation (CF) test for identification of 89 newly isolated dengue viruses of all 4 serotypes from the Caribbean, Asia and Africa showed 100% agreement. Although virus isolation rates were slightly lower than with the mosquito inoculation technique, use of the C6/36 cell culture system was much less time-consuming and allowed the processing of larger numbers of sera. Beginning in November 1981, a new virologic surveillance system was begun in Puerto Rico. From November 1981 to August 1982, dengue virus was isolated from 518 of 2702 sera from people with suspected dengue, an isolation rate of 19.2%. This system allows the dengue viruses being transmitted in an area to be monitored with a minimal amount of effort and provides the early warning capability necessary to predict epidemic dengue.<new para>ADDITIONAL ABSTRACT:<new para>This report describes the use of the C6/36 line of Aedes albopictus cells in the isolation of dengue viruses and of serotype-specific monoclonal antibodies in the identification of positive isolates. Full details are given together with the results of surveillance in Puerto Rico, using this system, over a 1-year period. During this period, the movement of dengue 1 and 4 viruses throughout the island was monitored.R.N.P. Sutton
KW - Cell cultures
KW - Complement fixation tests
KW - Dengue
KW - disease vectors
KW - identification
KW - IMMUNOFLUORESCENCE
KW - mosquito nets
KW - vectors
KW - Caribbean
KW - Puerto Rico
KW - Aedes albopictus
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - America
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Latin America
KW - Asian tiger mosquito
KW - fluorescent antibody technique
KW - IFAT
KW - mosquitoes
KW - Porto Rico
KW - West Indies
KW - Other Control Measures (HH700)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840514409&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of low levels of dietary lead and iron on hepatic RNA, protein, and minerals in young Japanese quail.
AU - Stone, C. L.
AU - Fox, M. R. S.
JO - Environmental Research
JF - Environmental Research
Y1 - 1984///
VL - 33
IS - 2
SP - 322
EP - 332
AD - Stone, C. L.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19841461963. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 7439-89-6, 7439-92-1, 63231-63-0. Subject Subsets: Human Nutrition; Poultry
N2 - From 1 day old groups of 10 Japanese quail were given purified diets with lead 0.2, 5.4 or 16.2 mg/kg as the acetate and iron 25 or 100 mg/kg for 2 weeks. Fe deficiency caused decreases in haemoglobin, Fe and manganese concentrations in the liver and in hepatic RNA synthesis, and increases in concentrations of Pb, calcium and molybdenum in the liver. Pb supplements caused Pb in liver to increase, and with adequate Fe in the diet, each increase in Pb caused a slight decrease in RNA concentration in the liver. Differences in Pb intake had no effect on DNA or protein synthesis, or on body weight or liver weight in relation to body weight. Fe deficiency caused Pb uptake by the liver to increase and affected RNA synthesis.
KW - intake
KW - Iron
KW - Lead
KW - liver
KW - minerals
KW - poultry
KW - protein synthesis
KW - RNA
KW - Japanese quails
KW - Coturnix
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - domesticated birds
KW - protein biosynthesis
KW - ribonucleic acid
KW - Physiology of Human Nutrition (VV120)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841461963&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of 10 elements in wastewater, plasma, and bovine liver by inductively coupled plasma emission spectrometry with electrothermal atomization.
AU - Blakemore, W. M.
AU - Casey, P. H.
AU - Collie, W. R.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1984///
VL - 56
IS - 8
SP - 1376
EP - 1379
AD - Blakemore, W. M.: Dep. Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Ark. 72079, USA.
N1 - Accession Number: 19841464477. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The estimation of calcium, cadmium, copper, iron, potassium, magnesium, sodium, phosphorus, lead and zinc is described.
KW - blood
KW - estimation
KW - Minerals
KW - Trace elements
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - microelements
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841464477&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of nitrosamines in malt and beer with a photoconductivity detector.
AU - Jasinski, J. S.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1984///
VL - 56
IS - 12
SP - 2214
EP - 2218
AD - Jasinski, J. S.: Food and Drug Administration, 1560 East Jefferson Ave., Detroit, MI 48207, USA.
N1 - Accession Number: 19851468169. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
KW - Beers
KW - estimation
KW - Malt
KW - nitrosamines
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851468169&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic determination of chemical residues in food using a rugged high-resolution mixed-bed column.
AU - Daft, J. L.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1984///
VL - 56
IS - 12
SP - 2687
EP - 2692
AD - Daft, J. L.: US Dep. Health and Human Services, Food and Drug Administration, Kansas City, MO 64106, USA.
N1 - Accession Number: 19851468665. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Human Nutrition
N2 - The estimation of chlorinated-organophosphorus pesticide residues in food is described.
KW - estimation
KW - Foods
KW - pesticides
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851468665&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid column method for determination of N-nitrosodimethylamine in malt.
AU - Havery, D. C.
AU - Perfetti, G. A.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 1
SP - 20
EP - 21
AD - Havery, D. C.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19841457653. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - Nitrosamines
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841457653&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of aflatoxins in peanut butter, using two liquid chromatographic methods: collaborative study.
AU - Campbell, A. D.
AU - Francis, O. J., Jr.
AU - Beebe, R. A.
AU - Stoloff, L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 2
SP - 312
EP - 316
AD - Campbell, A. D.: Food and Drug Administration, 4298, Elysian Fields Ave., New Orleans, LA 70122, USA.
N1 - Accession Number: 19841458520. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Two methods for determining aflatoxins in groundnut butter, one using normal phase and the other reverse phase liquid chromatography (LC) were studied by 8 and 10 collaborators, respectively. Fluorescence detection was used for the determinative step in both methods. The samples included spiked and naturally contaminated groundnut butter with total aflatoxin levels from about 5 to 20 ng/g and controls in a balanced pair design. For the normal phase LC method, recoveries of Bl, B2, G1 and G2 from spiked samples averaged 79, 92, 74 and 88%, respectively; for the reversed phase method, the recoveries were 103, 104, 89 and 163%. Both methods show an improved limit of detection and better within-laboratory precision over current AOAC methods; however, between-laboratory precision is no better, and the reverse phase method shows evidence of interferences being measured. For these reasons and because of no benfits of present value, neither method was submitted for adoption as official first action.
KW - aflatoxins
KW - biodeterioration
KW - contamination
KW - estimation
KW - groundnut butter
KW - liquid chromatography
KW - mycotoxins
KW - fungal toxins
KW - Peanut butter
KW - Techniques and Methodology (ZZ900)
KW - Other Produce (QQ070)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841458520&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of electron capture gas chromatographic method for determination of methyl mercury in freezer-case seafoods.
AU - Alvarez, G. H.
AU - Hight, S. C.
AU - Capar, S. G.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 4
SP - 715
EP - 717
AD - Alvarez, G. H.: Food and Drug Administration, Division of Chemical Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19841461271. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 593-74-8. Subject Subsets: Human Nutrition
KW - estimation
KW - frozen storage
KW - methylmercury
KW - Seafoods
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841461271&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic determination of deoxynivalenol in wheat with electron capture detection.
AU - Ware, G. M.
AU - Carman, A.
AU - Francis, O.
AU - Kuan, S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 4
SP - 731
EP - 734
AD - Ware, G. M.: Food and Drug Administration, Natural Toxins Research Center, 4298 Elysian Fields Ave., New Orleans, LA, UK.
N1 - Accession Number: 19841461276. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 51481-10-8. Subject Subsets: Human Nutrition; Animal Nutrition; Wheat, Barley & Triticale Abstracts; Medical & Veterinary Mycology
N2 - The method involves sample extraction with chloroform-ethanol (8 + 2), column chromatographic cleanup on silica gel of small particle size and derivatization with heptafluorobutyric acid anhydride using dimethylaminopyridine as a catalyst. The trisheptafluorobutyrate derivative of deoxynivalenol (DON) is determined by gas chromatography using an electron capture detector. Recoveries of DON added to wheat at levels of 118-1184 ng/g averaged 88% with a coefficient of variation of 8.6%.
KW - biodeterioration
KW - determination
KW - estimation
KW - gas chromatography
KW - Mycotoxins
KW - Vomitoxin
KW - wheat
KW - Triticum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - deoxynivalenol
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841461276&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total dietary fiber in foods, food products, and total diets: interlaboratory study.
AU - Prosky, L.
AU - Asp, N. G.
AU - Furda, I.
AU - Devries, J. W.
AU - Schweizer, T. F.
AU - Harland, B. F.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 6
SP - 1044
EP - 1052
AD - Prosky, L.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19851467047. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - Total dietary fibre (TDF) was estimated using a combination of enzymic and gravimetric procedures. Thirteen unknown products, including 2 mixed diets (one lacto-ovo vegetarian) were analysed by 32 analysts. Duplicate samples of dried foods were gelatinized with Termamyl, a heat-stable α-amylase, and then digested with protease and amyloglucosidase to remove protein and starch. Four volumes of 95% ethanol were added to precipitate the soluble dietary fibre. The total residue was filtered, and then washed with 74% ethanol, 95% ethanol, and acetone. After drying, the residue was weighed. Protein was estimated and another portion was ashed at 525°C and the ash was measured. TDF was calculated as the weight of the residue less the weight of protein and ash. Coefficients of variation for 10 of the samples were 3.0 to 26.4%. For 3 samples there were high coefficients of variation. The results compared satisfactorily with those obtained previously by the best method available for the individual foods studied.
KW - diets
KW - estimation
KW - Fibre
KW - foods
KW - fiber
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851467047&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of xanthomegnin in grains and animal feeds by liquid chromatography with electrochemical detection.
AU - Carman, A. S.
AU - Kuan, S. S.
AU - Francis, O. J.
AU - Ware, G. M.
AU - Luedtke, A. E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1984///
VL - 67
IS - 6
SP - 1095
EP - 1098
AD - Carman, A. S.: Food and Drug Administration, Natural Toxins Research Center, 4298 Elysian Fields Ave, New Orleans, LA 70122, USA.
N1 - Accession Number: 19851467050. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology; Wheat, Barley & Triticale Abstracts
N2 - A liquid chromatographic (LC) method is described which uses electrochemical reduction to determine xanthomegnin in mixed animal feeds and grains at levels ranging from 15 to 1200 ng/g. After separation by LC, xanthomegnin is detected by EC reduction at -0.16V. Results also demonstrate that this LC system can separate the related metabolites viomellein and rubrosulphin from each other and from xanthomegnin and that the same EC detection system can be used to detect these metabolites.
KW - biodeterioration
KW - Cereals
KW - contamination
KW - determination
KW - estimation
KW - Feeds
KW - Food grains
KW - liquid chromatography
KW - mycotoxins
KW - feeding stuffs
KW - fungal toxins
KW - xanthomegnin
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851467050&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rickettsia conorii isolated from Rhipicephalus sanguineus introduced into Switzerland on a pet dog.
AU - Péter, O.
AU - Burgdorfer, W.
AU - Aeschlimann, A.
AU - Chatelanat, P.
JO - Zeitschrift für Parasitenkunde
JF - Zeitschrift für Parasitenkunde
Y1 - 1984///
VL - 70
IS - 2
SP - 265
EP - 270
AD - Péter, O.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
N1 - Accession Number: 19842011036. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Veterinary Science
N2 - Four people near Geneva, Switzerland, developed a febrile illness during 1980 and 1981 that was diagnosed clinically as boutonneuse fever; all the patients had been in contact with a pet dog which is thought to have introduced the brown dog tick, Rhipicephalus sanguineus into the area from either southern France or Italy in 1976. All the rooms of the house in which the dog lived were infested with ticks and 40% of 75 nymphs and adults examined were infected with a rickettsial agent "biologically and antigenically indistinguishable from Rickettsia conorii".Carolyn A. Brown<new para>ADDITIONAL ABSTRACT:<new para>A survey in a household near Geneva, Switzerland, revealed that 30 (40%) of 75 nymphs and adults of Rhipicephalus sanguineus were infected with a rickettsial agent biologically and antigenically indistinguishable from Rickettsia conorii, the causal agent of boutonneuse fever. Introduced in 1976 from either southern France or Italy by the family's pet dog, the tick infestation had increased steadily until 1981, when control measures were initiated. During 1980-81, 4 persons associated with the dog contracted a febrile illness diagnosed as boutonneuse fever.
KW - disease vectors
KW - distribution
KW - dog diseases
KW - hosts
KW - Mediterranean spotted fever
KW - pets
KW - rickettsial diseases
KW - Tick infestations
KW - tickborne diseases
KW - typhus fevers
KW - vectors
KW - Europe
KW - Switzerland
KW - Acari
KW - dogs
KW - man
KW - Metastigmata
KW - Rhipicephalus
KW - Rhipicephalus sanguineus
KW - Rickettsia
KW - Rickettsia conorii
KW - Rickettsiaceae
KW - Rickettsiales
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - Homo
KW - Hominidae
KW - Primates
KW - Acari
KW - Ixodidae
KW - Metastigmata
KW - Rhipicephalus
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Rickettsia
KW - Developed Countries
KW - EFTA
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - boutonneuse fever
KW - conorii
KW - pet animals
KW - Rickettsia vector
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19842011036&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mosquito protein microassay - I. Protein determinations from small portions of single-mosquito homogenates.
AU - Brogdon, W. G.
JO - Comparative Biochemistry and Physiology, B (Comparative Biochemistry)
JF - Comparative Biochemistry and Physiology, B (Comparative Biochemistry)
Y1 - 1984///
VL - 79
IS - 3
SP - 457
EP - 459
AD - Brogdon, W. G.: Division of Parasitic Diseases, Center for Infectious Diseases, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19850525528. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A microassay is described for determining protein levels in individual mosquitoes. This method requires only a small portion of a homogenate of a single mosquito. Protein levels in Anopheles albimanus are positively correlated with body weight. Protein levels for different geographic strains of A. albimanus and different generations of laboratory rearings are compared.
KW - determination
KW - mosquito nets
KW - proteins
KW - Techniques
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - Techniques and Methodology (ZZ900)
KW - Other Control Measures (HH700)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850525528&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mosquito protein microassay - II. Modification for potential field use.
AU - Brogdon, W. G.
JO - Comparative Biochemistry and Physiology, B (Comparative Biochemistry)
JF - Comparative Biochemistry and Physiology, B (Comparative Biochemistry)
Y1 - 1984///
VL - 79
IS - 3
SP - 461
EP - 464
AD - Brogdon, W. G.: Division of Parasitic Diseases, Center for Infectious Diseases, Public Health Service, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19850525529. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A simple microassay is described for determining protein levels in individual mosquitoes; this method should be useful on a routine basis in the field. It requires only a small portion of a homogenate of a single mosquito. Sugar-fed adult females of Anopheles albimanus showed a slow decline in protein level for 14 days after emergence. Blood volumes and blood-meal protein levels were microassayed, and changes in protein level were monitored throughout the reproductive cycle. Protein levels of blood-fed females of A. albimanus returned only slowly to pre-feeding levels following egg deposition.
KW - determination
KW - mosquito nets
KW - proteins
KW - Techniques
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mosquitoes
KW - Techniques and Methodology (ZZ900)
KW - Other Control Measures (HH700)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850525529&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selected minerals in foods surveys, 1974 to 1981/82.
AU - Pennington, J. A. T.
AU - Wilson, D. B.
AU - Newell, R. F.
AU - Harland, B. F.
AU - Johnson, R. D.
AU - Vanderveen, J. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1984///
VL - 84
IS - 7
SP - 771
EP - 780
SN - 0002-8223
AD - Pennington, J. A. T.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19841464162. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - The 11 essential minerals were estimated in food commodity groups and in mixtures of foods representing the total diets of men 15 to 20 years old, infants and 2-year-old children in USA, in the Selected Minerals in Foods Survey of the Food and Drug Administration 1974-1982. The 3 diets were adequate in calcium, phosphate, magnesium, potassium, manganese and selenium, low in copper, and high in sodium and iodine. Iron was adequate in men's but not in infant's or children's diets, and zinc was adequate for children but not men or infants. The main sources of the minerals were dairy products, meat, fish, poultry, grain and cereal products, and fruit and vegetables. Some mineral levels varied significantly over the years for food commodity groups and total diets. There was no linear trend in total diets but 7 minerals decreased linearly with time in the men's food commodity groups. That was of no practical importance because the mineral content of the foods concerned was low, except for I in sugar and its adjuncts. The apparent trend in I probably reflected only the absence of collection of foods with erythrosine in some years. Minerals continue to be monitored in the annual Total Diet Study since it was revised in 1982 (NAR/A 53, 6159).
KW - diets
KW - Minerals
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841464162&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National nutrition monitoring system: implications for public health policy at FDA.
AU - Forbes, A. L.
AU - Stephenson, M. G.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1984///
VL - 84
IS - 10
SP - 1189
EP - 1193
SN - 0002-8223
AD - Forbes, A. L.: Office of Nutrition and Food Sciences, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19851467512. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
KW - monitoring
KW - Nutrition
KW - public health
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - surveillance systems
KW - United States of America
KW - Diet Studies (VV110)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851467512&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public perceptions of sodium labeling.
AU - Heimbach, J. T.
AU - Orwin, R. G.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1984///
VL - 84
IS - 10
SP - 1217
EP - 1219
SN - 0002-8223
AD - Heimbach, J. T.: Division of Consumer Studies, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19851467522. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7440-23-5. Subject Subsets: Human Nutrition
KW - behaviour
KW - consumer behaviour
KW - Foods
KW - labelling
KW - sodium
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - consumer behavior
KW - labeling
KW - labels
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851467522&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oral somatosensory factors in dietary self-selection in rats.
AU - Miller, M. G.
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
Y1 - 1984///
VL - 98
IS - 3
SP - 416
EP - 423
SN - 0735-7044
AD - Miller, M. G.: Division of Nutrition, HFF-265 Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19841463965. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - For studying the mechanisms of the control of protein intake, rats were subjected to partial trigeminal deafferentation. Oral somatosensory afferents from the lower anterior portion of the oral cavity were selectively sectioned, but somatosensation of the other parts of the mouth as well as gustatory and olfactory afferents were left intact. Rats were allowed to choose from two diets, only one of which contained protein. Before deafferentation, they chose a constant portion of their daily intake in the form of protein, 12.2%. After deafferentation, protein intake was all but eliminated at first but was resumed later; carbohydrate intake was reduced. When total intake had recovered to nearly preoperative values, the protein:total intake ratio remained impaired, with deficits that ranged from seemingly random selection to extreme preferences. The variability of dietary selection between days was considerably higher than before surgery. The involvement of learning processes in homeostasis is discussed.
KW - Food preferences
KW - mouth
KW - neurons
KW - Protein intake
KW - regulation
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet preferences
KW - nerve cells
KW - neurones
KW - taste preferences
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841463965&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oral somatosensory factors in dietary self-selection after food deprivation and supplementation.
AU - Miller, M. G.
AU - Teates, J. F.
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
Y1 - 1984///
VL - 98
IS - 3
SP - 424
EP - 434
SN - 0735-7044
AD - Miller, M. G.: Dep. Nutrition, HFF-268, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19841463969. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - To study the role of oral somatosensory input in the ability of rats to adjust protein selection to changing metabolic conditions, trigeminally deafferented rats were subjected to nutritional stresses while being allowed to balance protein and carbohydrate intake from two separate dietary fractions. Partly trigeminally deafferented rats that had recovered a normal protein ratio (protein:total intake) underwent total food deprivation or intragastric supplementation of protein or carbohydrate suspensions. In response to deprivation, control rats increased protein intake above amounts freely eaten, but not carbohydrate intake. In response to intragastric supplementation, they decreased protein intake disproportionately more than carbohydrate intake when the fluid consisted of protein and vice versa when the fluid consisted of carbohydrate. The recovered deafferented rats showed no selective increase in protein intake after deprivation and no differential compensation to nutrient supplementation. This suggests that recovery of the protein ratio after partial trigeminal deafferentation is incomplete and that the compensatory mechanisms used cannot fully replace the function of trigeminal somatosensory input. The possible role of other orosensory and of postingestional factors for recovery is discussed.
KW - food preferences
KW - mouth
KW - Neurons
KW - protein intake
KW - refeeding
KW - regulation
KW - starvation
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet preferences
KW - nerve cells
KW - neurones
KW - taste preferences
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19841463969&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trace element studies in weanling rats: maternal diets and baseline tissue mineral values.
AU - Rader, J. I.
AU - Wolnik, K. A.
AU - Gaston, C. M.
AU - Celesk, E. M.
AU - Peeler, J. T.
AU - Fox, M. R. S.
AU - Fricke, F. L.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1984///
VL - 114
IS - 10
SP - 1946
EP - 1954
SN - 0022-3166
AD - Rader, J. I.: Division of Nutrition, Food and Drug Administration (FDA), 1090 Tusculum Ave., Cincinnati, OH 45226, USA.
N1 - Accession Number: 19851466849. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - Variations were estimated in minerals in diet NIH-31, a breeding colony stock diet, and in tissues of weanling rats nursed by dams fed on this diet. Inductively coupled plasma-atomic emission spectrometry (ICP-AES) was used to estimate 9 elements (Ca, Cu, Fe, K, Mg, Mn, Na, P and Zn) in diet and in liver, kidney, spleen, duodenum and femur from rats 22 to 26 days old. Wet digestions were performed in mixtures of nitric, perchloric and sulphuric acids (diets and soft tissues) or nitric and perchloric acids (femur). Solution concentrations ranged from less than 25 ng/ml for the trace elements to more than 100 μg/ml for the major elements. Large variations in mineral content were found between batches of commercially prepared NIH-31 diet; relative amounts of Cu, Fe, Mn and Zn varied considerably. Significant differences in concentrations of major and trace minerals in liver, kidney, spleen and duodenal tissue were found among groups of weanling rats obtained from the same supplier at different times. Mn was readily found in all tissues except spleen, where it was below detection limits. The precision obtained with the ICP-AES methodology has significant advantages for establishing variations in tissue mineral concentrations.
KW - diets
KW - minerals
KW - Mothers
KW - progeny
KW - tissues
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851466849&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The Anopheles pseudopunctipennis complex (summary).
AU - Vargas, L.
AU - Rosay, B.\Collett, G. C.
A2 - Rosay, B.
A2 - Collett, G. C.
T2 - Proceedings and papers of the Thirty-Sixth Annual Meeting of the Utah Mosquito Abatement Association held at Eccles Conference Center, Utah State University, Logan, Utah, October 3-4, 1983
JO - Proceedings and papers of the Thirty-Sixth Annual Meeting of the Utah Mosquito Abatement Association held at Eccles Conference Center, Utah State University, Logan, Utah, October 3-4, 1983
JF - Proceedings and papers of the Thirty-Sixth Annual Meeting of the Utah Mosquito Abatement Association held at Eccles Conference Center, Utah State University, Logan, Utah, October 3-4, 1983
Y1 - 1984///
SP - 35
EP - 35
CY - Salt Lake City, Utah; USA
PB - Utah Mosquito Abatement Association
AD - Vargas, L.: Public Health Service, Mexico City, Mexico, D. F.
N1 - Accession Number: 19840517627. Publication Type: Conference paper. Language: English. Subject Subsets: Medical & Veterinary Entomology
N2 - The irregular but extensive distribution of Anopheles pseudopunctipennis Theo. from the southern Nearctic Region to the southern Neotropical Region implies the existence of variants with genetic barriers. Although chromosome studies provided no conclusive evidence of subspecies, taxonomic characters in larvae, pupae, adult females and male genitalia permitted separation of the forms into A. p. franciscanus McCracken, A. p. boydi Vargas and A. p. willardi Vargas as well as the typical form, and distinctive egg shapes were found for each type.
KW - distribution
KW - mosquito nets
KW - taxonomy
KW - America
KW - Anopheles franciscanus
KW - Anopheles pseudopunctipennis
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles pseudopunctipennis
KW - Anopheles pseudopunctipennis boydi
KW - Anopheles pseudopunctipennis willardi
KW - mosquitoes
KW - systematics
KW - Taxonomy and Evolution (ZZ380)
KW - Other Control Measures (HH700)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19840517627&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intestinal infection and malnutrition initiate acquired immune deficiency syndrome (AIDS).
AU - Archer, D. L.
AU - Glinsmann, W. H.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1985///
VL - 5
IS - 1
SP - 9
EP - 19
SN - 0271-5317
AD - Archer, D. L.: Division of Microbiology, Food and Drug Administration, Dep. Health and Human Services, Washington, DC, USA.
N1 - Accession Number: 19851471444. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Human Nutrition; Public Health
N2 - AIDS is a complex immunodeficiency syndrome affecting a limited target population, mainly male homosexuals. The immunological dysfunctions in AIDS, or persons with the AIDS prodrome, are explained in terms of multiple pathogen-induced changes in the gastrointestinal tract which result in malabsorption and malnutrition. Malnutrition need not be severe but may be due to failure to transport one or several nutrients essential for immune functions. Change of gastrointestinal permeability results in a greater uptake of normally excluded microbial products possibly resulting in latent virus activation or more replication of viruses, including the retrovirus HTLV-III. Once that has occurred, transmissible agents may cause or predispose to AIDS in other susceptible groups such as haemophiliacs, persons receiving multiple blood transfusions, drug users sharing needles, populations with repeated close contact and susceptible populations because of genetic, environmental or disease state. The combination of rigorous parenteral nutrient repletion and antibiotic treatment aimed at abrogating the intestinal infections, and immunological treatment, may be effective in addressing the underlying causes of the immune defects in AIDS. Prevention should be directed toward decreasing repeated polymicrobial enteric infections and their attendant malabsorption, e.g., gay bowel syndrome, in addition to lessening exposure to circulating transmissible agents.<new para>ADDITIONAL ABSTRACT:<new para>An hypothesis which invokes multiple intestinal infections (leading to malabsorption) and subsequent malnutrition as the major initiating factors in the aetiology of AIDS is presented. Malnutrition, which may not necessarily be severe, is associated with a failure of intestinal absorption of certain nutrients that are essential for normal immune function; deficiency of some of these nutrients predisposes to infection by viruses, including HTLV-III. Simultaneously, altered gastrointestinal permeation leads to passage of microbial products across the intestinal mucosa resulting in either latent activation or enhanced replication of viruses, including HTLV-III. It is argued that antibiotic and anti-parasitic treatment (aimed at the intestinal infections associated with the gay bowel syndrome), parenteral nutrition (to counteract the malnutrition), and "immunologic therapies" (lymphokines and interferons) might therefore be of value in treatment.[The various factors mentioned in this hypothesis-intestinal infection(s), malabsorption, malnutrition, abnormal small-intestinal permeation, compromised immune response, the HTLV-III, etc-are obviously all relevant to AIDS, but to establish whether any one or more of these is or are primary factors in its pathogenesis would be a very difficult task indeed.]G.C. Cook
KW - Acquired immune deficiency syndrome
KW - aetiology
KW - deficiency
KW - Immunity
KW - infection
KW - intestines
KW - malabsorption
KW - malnutrition
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - causal agents
KW - etiology
KW - hypotheses
KW - malabsorption syndrome
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851471444&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Deficient levels of dietary selenium suppress the antibody response in first and second generation mice.
AU - Mulhern, S. A.
AU - Taylor, G. L.
AU - Magruder, L. E.
AU - Vessey, A. R.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1985///
VL - 5
IS - 2
SP - 201
EP - 210
SN - 0271-5317
AD - Mulhern, S. A.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19851471933. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 7782-49-2. Subject Subsets: Human Nutrition
N2 - The effect of a selenium-deficient diet during prenatal and postnatal development on the immune response was investigated in C57BL/6J mice. When the selenium-deficient diet was given after weaning, there was no effect on the serum chemistries, primary antibody response or lymphoid organ weight; the secondary antibody response to a T-cell dependent antigen was diminished. The selenium-deficient diet during pregnancy, lactation and after weaning development had no effect on the serum chemistry values or lymphoid organs; bodyweights and primary and secondary antibody responses were decreased. Results were similar in assay systems in vivo and in vitro.
KW - deficiency
KW - IMMUNE RESPONSE
KW - Lactation
KW - Pregnancy
KW - progeny
KW - selenium
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - immunity reactions
KW - immunological reactions
KW - Human Physiology and Biochemistry (VV050)
KW - Host Resistance and Immunity (HH600)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851471933&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of three dietary sources of choline on liver lipids in rats fed animal or plant protein.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1985///
VL - 5
IS - 5
SP - 473
EP - 485
SN - 0271-5317
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19851473604. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 62-49-7. Subject Subsets: Human Nutrition; Soyabeans
N2 - Interrelations among choline source, choline chloride (CC), egg lecithin (EL) and soyabean lecithin (SL), choline content, 0, 0.1 and 0.2% added to the diet, and protein source, lactalbumin (LA) and soya flour (SF), were studied. Male weanling rats were fed on purified 10% protein diets adequate in all other vitamins and minerals for 4 weeks. For both protein sources, the addition of each choline source to the diet caused a significant decrease in liver total lipid, triglycerides and cholesterol. At 0.2% dietary choline, liver phospholipids (percentage of total lipid) were less for SL and EL than for CC. In rats fed on LA, the liver phospholipid values for SL, EL and CC were 50, 57 and 74%, respectively. In rats fed on SF, the liver phospholipid values for SL, EL and CC were 46, 46 and 56%, respectively. For each choline content and choline source, SF-fed rats had higher liver cholesterol values than rats fed on LA. All choline sources decreased liver cholesterol to a similar extent with LA, but EL and SL were not as effective as CC in decreasing liver cholesterol with SF. The findings suggest that protein source influences the magnitude of the lipid changes and that the 3 choline sources are unequal in their role in lipid metabolism.
KW - Animal proteins
KW - choline
KW - diets
KW - lipids
KW - liver
KW - phosphatidylcholines
KW - Plant proteins
KW - sources
KW - soyabean flour
KW - soyabeans
KW - Glycine (Fabaceae)
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - choline sources
KW - lecithins
KW - lipins
KW - soybean flour
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
KW - Crop Produce (QQ050)
KW - Animal Nutrition (General) (LL500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851473604&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enteric infections and other cofactors in AIDS.
AU - Archer, D. L.
AU - Glinsmann, W. H.
JO - Immunology Today
JF - Immunology Today
Y1 - 1985///
VL - 6
IS - 10
SP - 292
EP - 295
SN - 0167-4919
AD - Archer, D. L.: Centre for Food Safety and Applied Nutrition, Food and Drug Administration, Washington DC 20204, USA.
N1 - Accession Number: 19862026515. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - As yet, there are no clear reasons for the different clinical manifestations of AIDS among individuals. The authors discuss the history of AIDS and propose a link between HTLV-III infection and gastrointestinal disease processes with attendant malabsorption. "Maximizing the nutritional status and minimizing the incidence of gastrointestinal infection of individuals infected with HTLV-III may prevent development of the full-blown AIDS".D.W. FitzSimons
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Enteritis
KW - gastrointestinal diseases
KW - HIV infections
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - ileitis
KW - jejunitis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862026515&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin A status and metabolism of benzo[a]pyrene in the rat.
AU - Hauswirth, J. W.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1985///
VL - 7
IS - 1/2
SP - 53
EP - 58
SN - 0163-5581
AD - Hauswirth, J. W.: Center for Veterinary Medicine, Division of Toxicology, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19861485686. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 50-32-8, 68-26-8. Subject Subsets: Human Nutrition
N2 - Male Sprague-Dawley rats were maintained on a vitamin A-deficient diet for 5 weeks when hepatic cytochrome P-450 values in vitamin A-deficient rats were 65% of those in rats on a complete diet. However, the hepatic rate of benzo[a]pyrene metabolism was significantly greater in vitamin A-deficient rats than in those on a complete diet. The pattern of metabolites separable by thin-layer chromatography was similar in the 2 groups. Benzo[a]pyrene induced its own metabolism by a slightly greater amount in the vitamin-sufficient rats, but it was not to the level of the deficient group, although the cytochrome P-450 values were still below those of the deficient rats. In discussing lung microsomes, benzo[a]pyrene pre-treatment of deficient rats resulted in slightly increased values for cytochrome P-450 and a slightly greater rate of metabolism of benzo[a]pyrene compared with rats on the complete diet.
KW - benzopyrene
KW - metabolism
KW - RETINOL
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - status
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485686&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid screening method for determining myristicin in fresh and frozen carrots by gas chromatography.
AU - Carman, A. S., Jr.
AU - Kuan, S. S.
AU - Francis, O. J., Jr.
AU - Ware, G. M.
AU - Luedtke, A. E.
JO - Analytical Letters
JF - Analytical Letters
Y1 - 1985///
VL - 18
IS - B9
SP - 1167
EP - 1175
SN - 0003-2719
AD - Carman, A. S., Jr.: Natural Toxins Research Center, US Food and Drug Administration, 4298 Elysian Fields Ave., New Orleans, LA 70122, USA.
N1 - Accession Number: 19851476907. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Horticultural Science; Human Nutrition
N2 - The estimation of the naturally occurring toxin, myristicin, is described. Values for fresh carrots from 5 areas were 1.1-16.6, mean 5.2, for 12 samples of frozen carrots <0.5-1.1, and for canned carrots (12 samples) ≤0.5 μg/g.
KW - carrots
KW - estimation
KW - Toxins
KW - Daucus carota
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Araliales
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851476907&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation of St Louis encephalitis virus from adult Dermacentor variabilis (Acari: Ixodidae).
AU - McLean, R. G.
AU - Francy, D. B.
AU - Monath, T. P.
AU - Calisher, C. H.
AU - Trent, D. W.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1985///
VL - 22
IS - 2
SP - 232
EP - 233
SN - 0022-2585
AD - McLean, R. G.: Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, Fort Collins, Colorado 80522, USA.
N1 - Accession Number: 19852022732. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health; Tropical Diseases; Medical & Veterinary Entomology; Veterinary Science; Veterinary Science
N2 - "St Louis encephalitis (SLE) virus was isolated from adult Dermacentor variabilis ticks removed from a raccoon (Procyon lotor) captured in Memphis, Tennessee, USA, on 24 May 1979. Neutralizing antibody against SLE virus was detected in mammals from the same area. The epidemiologic significance of the isolate is unknown. ... This was the first field isolation of SLE virus from a tick and represents the only other SLE virus isolation from a nonmosquito vector besides the isolations from bird mites in the 1940s."<new para>ADDITIONAL ABSTRACT:<new para>St. Louis encephalitis virus (SLE) was isolated from adults of Dermacentor variabilis removed from a raccoon (Procyon lotor) caught in Memphis, Tennessee. Neutralizing antibodies against SLE were detected in mammals from the same area. This is the 1st record of a field isolation of SLE from a tick and the 2nd record of one from a vector other than a mosquito.
KW - arboviruses
KW - disease vectors
KW - distribution
KW - encephalitis
KW - hosts
KW - vectors
KW - viral diseases
KW - Wild animals
KW - North America
KW - Tennessee
KW - USA
KW - Acari
KW - Dermacentor
KW - Dermacentor variabilis
KW - Flavivirus
KW - Ixodidae
KW - Metastigmata
KW - Procyon lotor
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - viruses
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Dermacentor
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Procyon
KW - Procyonidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - Flavivirus
KW - America
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - East South Central States of USA
KW - arthropod-borne viruses
KW - encephalomyelitis
KW - United States of America
KW - variabilis
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852022732&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal occurrence of fleas (Siphonaptera) on rodents in a foothills habitat in Larimer County, Colorado, USA.
AU - Campos, E. G.
AU - Maupin, G. O.
AU - Barnes, A. M.
AU - Eads, R. B.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1985///
VL - 22
IS - 3
SP - 266
EP - 270
SN - 0022-2585
AD - Campos, E. G.: Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado 80522-2087, USA.
N1 - Accession Number: 19860531031. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - During a flea ecology study in 1974-75 in Colorado, rodents were trapped alive and examined for ectoparasites in a foothills habitat in Larimer County. The commonest rodent species recovered were Peromyscus maniculatus (on which the commonest flea species were Monopsyllus wagneri [Aetheca wagneri], Micropsylla sectilis [Rhodinopsylla sectilis] and Malaraeus euphorbi [Amaradix euphorbi]), P. difficilis (on which the commonest flea was Aetheca wagneri) and Neotoma mexicana (on which the commonest flea was Stenistomera alpina). No host specificity was shown by the fleas on Peromyscus and associated small mammals. Marked seasonal variations in the proportion of P. maniculatus infected, in number of fleas per mouse and in species composition of the flea population were noted.
KW - ecology
KW - population dynamics
KW - Colorado
KW - North America
KW - USA
KW - Aetheca
KW - Aetheca wagneri
KW - Amaradix
KW - Amaradix euphorbi
KW - Neotoma mexicana
KW - Peromyscus difficilis
KW - Peromyscus maniculatus
KW - Rhadinopsylla sectilis
KW - Siphonaptera
KW - Stenistomera
KW - Stenistomera alpina
KW - Neotoma
KW - Sigmodontinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Peromyscus
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Ceratophyllidae
KW - Siphonaptera
KW - Aetheca
KW - Amaradix
KW - Rhadinopsylla
KW - Hystrichopsyllidae
KW - Stenistomera
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - rodent hosts
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19860531031&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - International survey of apolipoproteins A1 and B measurements (1983-1984).
AU - Cooper, G. R.
AU - Smith, S. J.
AU - Wiebe, D. A.
AU - Kuchmak, M.
AU - Hannon, W. H.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1985///
VL - 31
IS - 2
SP - 223
EP - 228
SN - 0009-9147
AD - Cooper, G. R.: Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19851469749. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
KW - apolipoproteins
KW - blood
KW - estimation
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851469749&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Six methods for isolating high-density lipoprotein compared, with use of the reference method for quantifying cholesterol in serum.
AU - Wiebe, D. A.
AU - Smith, S. J.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1985///
VL - 31
IS - 5
SP - 746
EP - 750
SN - 0009-9147
AD - Wiebe, D. A.: Analytical Biochemistry Branch, Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19851472189. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - High density lipoprotein
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851472189&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Accumulation of dietary β-carotene in the rat.
AU - Wamer, W.
AU - Giles, A., Jr.
AU - Kornhauser, A.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1985///
VL - 32
IS - 2
SP - 295
EP - 301
AD - Wamer, W.: Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19861477844. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
N2 - For up to 17 weeks 60 female Osborne-Mendel rats weighing 200 to 300 g were given a stock diet without or with 1% β-carotene added. After 14 weeks on the diet with added β-carotene mean β-carotene in serum was 66 ng/ml and in skin 146 ng/g. By 17 weeks serum β-carotene was 34 ng/ml; the reason for the decrease was not known. Serum and skin from controls showed no significant β-carotene content.
KW - beta-carotene
KW - retention
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861477844&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mass spectral identification of a metabolite of chlorpropham in potatoes.
AU - Heikes, D. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1985///
VL - 33
IS - 2
SP - 246
EP - 249
SN - 0021-8561
AD - Heikes, D. L.: Total Diet Res. Cent., Food and Drug Administration, Kansas City, MO 64106, USA.
N1 - Accession Number: 19850776274. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 101-21-3. Subject Subsets: Human Nutrition; Horticultural Science; Field Crops; Potatoes
N2 - Residues of chlorpropham (a postharvest sprout suppressant) were found in table-ready potatoes. Another compound, detected by GC, was associated with these residues. The compound was identified by GC MS as isopropyl N-(3-chloro-4-methoxyphenyl) carbamate. Tubers, previously free of all detectable residues, were found to contain this compound 21 days after chlorpropham application, thus confirming it to be a previously unrecorded metabolite of chlorpropham. This metabolite reached concn. ≤0.063 p.p.m. in table-ready potatoes.
KW - chlorpropham
KW - Growth regulators
KW - plant composition
KW - plant growth regulators
KW - Potatoes
KW - residues
KW - tubers
KW - Solanum tuberosum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - chemical constituents of plants
KW - growth substances
KW - plant growth substances
KW - plant hormones
KW - Plant Composition (FF040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19850776274&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elements in major raw agricultural crops in the United States. 3. Cadmium, lead, and eleven other elements in carrots, field corn, onions, rice, spinach, and tomatoes.
AU - Wolnik, K. A.
AU - Fricke, F. L.
AU - Capar, S. G.
AU - Meyer, M. W.
AU - Satzger, R. D.
AU - Bonnin, E.
AU - Gaston, C. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1985///
VL - 33
IS - 5
SP - 807
EP - 811
SN - 0021-8561
AD - Wolnik, K. A.: Food and Drug Administration, Cincinnati, OH 45202, USA.
N1 - Accession Number: 19860785484. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 7440-43-9, 7440-70-2, 7440-50-8, 7439-89-6, 7439-92-1, 7439-95-4, 7439-96-5, 7439-98-7, 7440-02-0, 7723-14-0, 7440-09-7, 7440-23-5, 7440-66-6. Subject Subsets: Field Crops; Human Nutrition; Rice; Horticultural Science; Maize; Maize
N2 - 1215 samples of carrots, maize, onions, rice, spinach and tomatoes were collected from major USA growing areas with minimal contamination by human activities other than normal agricultural practices. Mean Cd contents in carrots, maize, onions, rice, spinach and tomatoes were 0.028, 0.012, 0.011, 0.012, 0.065 and 0.017 µg/g (wet weight), resp.; mean Pb contents were 0.009, 0.022, 0.005, 0.007, 0.045 and 0.002 µg/g, resp. Contents of other elements are also presented.<new para>ADDITIONAL ABSTRACT:<new para>Mean values for cadmium in 6 crops from the main growing areas in the USA were carrots 28, maize 12, onions 11, rice 12, spinach 65 and tomatoes 17 ng/g. Corresponding values for lead were 9, 22, 5, 7, 45 and 2. Values are also tabulated for P, Ca, Cu, Fe, K, Mg, Mn, Mo, Na, Ni and Zn.
KW - cadmium
KW - Calcium
KW - Carrots
KW - composition
KW - Copper
KW - elements
KW - grain
KW - heavy metals
KW - Iron
KW - lead
KW - Magnesium
KW - Maize
KW - Manganese
KW - Molybdenum
KW - Nickel
KW - NUTRITIVE VALUE
KW - Onions
KW - Phosphorus
KW - plant composition
KW - Potassium
KW - Rice
KW - root crops
KW - Sodium
KW - Spinach
KW - Tomatoes
KW - trace elements
KW - Vegetables
KW - Zinc
KW - USA
KW - Alliaceae
KW - Allium
KW - Apiaceae
KW - Chenopodiaceae
KW - Daucus carota
KW - Oryza
KW - plants
KW - Solanaceae
KW - Solanum lycopersicum
KW - Spinacia oleracea
KW - Zea mays
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Alliaceae
KW - Liliaceae
KW - Apiales
KW - dicotyledons
KW - Caryophyllales
KW - Daucus
KW - Apiaceae
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Poaceae
KW - Cyperales
KW - Spinacia
KW - Chenopodiaceae
KW - Zea
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Araliales
KW - chemical constituents of plants
KW - corn
KW - grains
KW - Lycopersicon esculentum
KW - microelements
KW - Mn
KW - Mo
KW - nutritional value
KW - paddy
KW - quality for nutrition
KW - United States of America
KW - vegetable crops
KW - Plant Composition (FF040)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19860785484&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro assessment of zinc binding to protein foods as a potential index of zinc bioavailability. Comparison of in vitro and in vivo data.
AU - Jones, A. O. L.
AU - Fox, M. R. S.
AU - Fry, B. E., Jr.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1985///
VL - 33
IS - 6
SP - 1123
EP - 1128
SN - 0021-8561
AD - Jones, A. O. L.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19861479660. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-66-6. Subject Subsets: Human Nutrition; Soyabeans
N2 - An equilibrium dialysis test in vitro to estimate the strength of zinc binding to protein foods was developed for predicting Zn bioavailability. Soya flour, soya concentrate, casein and dried egg white were labelled with 65ZnCl2 before dialysis. The conditions included 24-h dialysis at pH 7.4 against 3 buffers. Dialysate and retentate 65Zn were measured. The protein foods retained 65Zn in the following order according to buffer: 0.05 M Tris buffer > Tris plus 0.01 M histidine hydrochloride > Tris plus 0.01 M disodium EDTA. The bioavailability of residual 65Zn in casein, egg white, soya concentrate and soya flour after each buffer treatment was estimated by giving single doses of the protein foods to young Japanese quail. For these protein foods, the best agreement between data in vitro and in vivo was obtained using the Tris-histidine buffer and the whole-body 65Zn retentions from the labelled casein and egg white (no treatment). The data suggest that this in vitro test could be useful for preliminary assessment of Zn bioavailability of protein foods.
KW - availability
KW - concentrates
KW - estimation
KW - feeds
KW - plant proteins
KW - protein foods
KW - Soyabean flour
KW - soyabeans
KW - Zinc
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - feeding stuffs
KW - protein feeds
KW - soybean flour
KW - soybeans
KW - Techniques and Methodology (ZZ900)
KW - Other Produce (QQ070)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861479660&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acquisition of dietary self-selection in rats with normal and impaired oral sensation.
AU - Miller, M. G.
AU - Teates, J. F.
JO - Physiology and Behavior
JF - Physiology and Behavior
Y1 - 1985///
VL - 34
IS - 3
SP - 401
EP - 408
AD - Miller, M. G.: Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19851472913. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition
N2 - To study the mechanisms of dietary self-selection, the dietary choice behaviour of rats was observed for up to 5 weeks, beginning on the first day of exposure to 2 nutritionally different diets, a high-protein diet (44% protein) and a protein-free carbohydrate diet. In experiment 1 normal rats selected equal amounts of the 2 selection diets at first and during a 7-day period gradually modified the choice ratio until a stable protein intake of 14.6% of total intake was reached. In experiment 2 rats were subjected to partial trigeminal deafferentation, which impairs oral somatosensory input (touch, temperature, pain), before the 2 selection diets were introduced. The deafferented rats did not develop a stable selection pattern; their protein ratio varied over the entire possible range (0 to 44%) throughout the experiment. It is hypothesized that quantitative protein/carbohydrate selection involves an associative learning process in which somatosensory inputs from the feeding activity, from the properties of the food or from both, link dietary choice behaviour to later metabolic consequences.
KW - behaviour
KW - Feeding behaviour
KW - nervous system
KW - regulation
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - feeding behavior
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851472913&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of phytic acid in foods by ion chromatography with post-column derivatization.
AU - Phillippy, B. Q.
AU - Johnston, M. R.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1985///
VL - 50
IS - 2
SP - 541
EP - 542
SN - 0022-1147
AD - Phillippy, B. Q.: Division of Food Technology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19851471945. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 83-86-3. Subject Subsets: Human Nutrition
KW - estimation
KW - Foods
KW - phytic acid
KW - inositol hexaphosphate
KW - phytate
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851471945&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of neomycin in animal tissues, using ion-pair liquid chromatography with fluorometric detection.
AU - Shaikh, B.
AU - Allen, E. H.
AU - Gridley, J. C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 1
SP - 29
EP - 36
AD - Shaikh, B.: Food and Drug Administration, Division of Veterinary Medical Research, Beltsville, MD 20705, USA.
N1 - Accession Number: 19852258500. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 1404-04-2. Subject Subsets: Human Nutrition; Veterinary Science
KW - Antibiotics
KW - assays
KW - Chemical analysis
KW - Drug residues
KW - estimation
KW - kidneys
KW - Meat inspection
KW - muscles
KW - Neomycin
KW - tissues
KW - Techniques and Methodology (ZZ900)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Meat Produce (QQ030)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19852258500&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modification of the rapid screening method for aflatoxin in corn for quantitative use.
AU - Spilmann, J. R., Jr.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 3
SP - 453
EP - 456
AD - Spilmann, J. R., Jr.: Food and Drug Administration, New Orleans District Lab., 4298 Elysian Fields Ave., New Orleans, LA 70122, USA.
N1 - Accession Number: 19851472054. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition; Maize; Medical & Veterinary Mycology
N2 - A study was made to determine if the official AOAC method for screening of aflatoxin in maize could be modified for use as a quantitative method. Several different maize products were analyzed using the modified method, with an average saving of over 1 h/sample vs. the CB method. Average recoveries of aflatoxin B1 were 94% for the low level spiked samples and 108% for the high level. Samples of maize and maize products containing naturally incurred aflatoxin were also analyzed with the modified method, and the results compared favourably with those obtained by the CB method.
KW - Aflatoxins
KW - biodeterioration
KW - estimation
KW - maize
KW - Mycotoxins
KW - Quantitative techniques
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851472054&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin A and vitamin E content of infant formulas produced in the United States.
AU - Landen, W. O., Jr.
AU - Hines, D. M.
AU - Hamill, T. W.
AU - Martin, J. I.
AU - Young, E. R.
AU - Eitenmiller, R. R.
AU - Soliman, A. G. M.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 3
SP - 509
EP - 511
AD - Landen, W. O., Jr.: Food and Drug Administration, 1182 W Peachtree St, NW, Atlanta, GA 30309, USA.
N1 - Accession Number: 19851472070. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 1406-18-4, 68-26-8. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - Vitamin A (vitamin A palmitate) and vitamin E (α-tocopheryl acetate) were estimated in 77 samples of fortified infant formulas manufactured by 4 firms in the USA from 1981 to 1983 and were compared by formulation base (soya, milk) and manufacturing firm. The respective values were 248-614, mean 454, and 1.1-5.0, 2.0 IU/100 kcal. There were no significant differences between milk- and soyabean-based formulas. When mean values were compared on an IU/100 kcal or percentage of label declaration basis, there were significant differences among firms. Mean vitamin A values, compared with label declarations, ranged from 126% for ready-to-use formulas to 139% for powders. Corresponding values for vitamin E ranged from 97% for formulas to 118% for concentrates. Except for one sample that contained vitamin A 248 IU/100 kcal, the formulas met the requirements of the 1980 Infant Formula Act.
KW - composition
KW - Infant foods
KW - Infant formulae
KW - milk products
KW - RETINOL
KW - Soya milk
KW - tocopherols
KW - vitamin E
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - baby foods
KW - dairy products
KW - infant formula
KW - infant formulas
KW - soy milk
KW - soyabean milk
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
KW - Feed Composition and Quality (RR300)
KW - Crop Produce (QQ050)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851472070&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methods of analysis for infant formula: Food and Drug Administration and Infant Formula Council Collaborative Study.
AU - Tanner, J. T.
AU - Barnett, S. A.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 3
SP - 514
EP - 522
AD - Tanner, J. T.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19851472078. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A collaborative study was made to estimate vitamins A, B-6, and C, riboflavin, niacin, calcium, magnesium, iron, zinc, copper, manganese, sodium and potassium. The coefficients of variation were usually as good as those that could be predicted from other collaborative studies. The methods, except that for vitamin A, were adopted as official first action.
KW - analytical methods
KW - Infant foods
KW - Infant formulae
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - baby foods
KW - infant formula
KW - infant formulas
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851472078&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Negative ion chemical ionization mass spectrometric method for confirmation of identity of aflatoxin B1: collaborative study.
AU - Park, D. L.
AU - Diprossimo, V.
AU - Abdel-Malek, E.
AU - Trucksess, M. W.
AU - Nesheim, S.
AU - Brumley, W. C.
AU - Sphon, J. A.
AU - Barry, T. L.
AU - Petzinger, G.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 4
SP - 636
EP - 640
AD - Park, D. L.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19851473871. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology
N2 - Twelve partially purified, dry film extracts from naturally and artificially contaminated roasted groundnuts, cottonseed and ginger root containing varying quantities of aflatoxin B1 were analysed by the participating labs. Aflatoxin B1 identity was confirmed in 19.5, 90.9 and 100% of samples containing < 5, 5-10 and > 10 ng/g aflatoxin B1, respectively. The method has been adopted official first action.
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - cottonseed
KW - detection
KW - estimation
KW - ginger
KW - groundnuts
KW - mass spectrometry
KW - Mycotoxins
KW - Arachis hypogaea
KW - Zingiber
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - fungal toxins
KW - peanuts
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851473871&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thin layer chromatographic determination of sterigmatocystin in cheese.
AU - Francis, O. J., Jr.
AU - Ware, G. M.
AU - Carman, A. S.
AU - Kuan, S. S.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 4
SP - 643
EP - 645
AD - Francis, O. J., Jr.: Food and Drug Administration, Natural Toxins Research Center, 4298 Elysian Fields Ave., New Orleans, LA 70122, USA.
N1 - Accession Number: 19851473872. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 10048-13-2. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology; Dairy Science
N2 - Using the technique described, sterigmatocystin could be detected and quantified at 2 and 5 µg/kg, respectively. Av. recoveries were 88.3 and 86.4% at the 10 and 25 µg/kg levels, respectively.\In the one-dimensional TLC method developed for determining sterigmatocystin, cheese was extracted with acetonitrile-4% KCl (85 + 15). A simplified liquid-liquid partition cleanup was used, and the sample extract passed through a cupric carbonate column for final purification. Sterigmatocystin was visualized by spraying the plate with Al2Cl6. The fluorescence of the spot was enhanced 10-fold by additional spraying with a silicone-ether mixture, enabling sterigmatocystin detection and quantitation at 2 and 5 µg/kg, resp. Average recoveries were 88.3 and 86.4% at the 10 and 25 µg/kg levels, resp. [from Gouda cheese samples].
KW - biodeterioration
KW - Cheeses
KW - contamination
KW - Cows
KW - determination
KW - estimation
KW - Mycotoxins
KW - sterigmatocystin
KW - thin layer chromatography
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total dietary fiber in foods and food products: collaborative study.
AU - Prosky, L.
AU - Asp, N. G.
AU - Furda, I.
AU - DeVries, J. W.
AU - Schweizer, T. F.
AU - Harland, B. F.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 4
SP - 677
EP - 679
AD - Prosky, L.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19851473877. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition
N2 - A collaborative study was made of an enzymic/gravimetric method for estimating total dietary fibre. The method was adopted as official first action.
KW - estimation
KW - fibre
KW - Foods
KW - fiber
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851473877&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mass spectrometry and identification of sterols in vegetable oils as butyryl esters and relative quantitation by gas chromatography with flame ionization detection.
AU - Brumley, W. C.
AU - Sheppard, A. J.
AU - Rudolf, T. S.
AU - Shen C. S. J.
AU - Yasaei, P.
AU - Sphon, J. A.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 4
SP - 701
EP - 709
AD - Brumley, W. C.: Food and Drug Administration, Division of Chemical Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19851473889. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - plant oils
KW - Sterols
KW - vegetable oils
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851473889&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1978-September 1979.
AU - Gartrell, M. J.
AU - Craun, J. C.
AU - Podrebarac, D. S.
AU - Gunderson, E. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 5
SP - 842
EP - 861
AD - Gartrell, M. J.: Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19851475445. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration conducts Total Diet Studies to estimate the dietary intake of selected pesticides, industrial chemicals, and elements, including radionuclides. These studies involve the retail purchase and analysis of foods representative of the diets of infants, toddlers and adults. The individual food items are separated into a number of food groups, each of which is analysed as a composite. This report summarizes the results for infant and toddler total diet samples collected in 10 cities between October 1978 and September 1979. The average and range of concentrations, and calculated average daily intake of the chemicals found are presented. The average daily intakes of chemicals are similar to those in the several preceding years and generally are within acceptable limits. The results for the adult diet are reported separately.
KW - children
KW - contaminants
KW - Diets
KW - Infants
KW - Pesticides
KW - RADIONUCLIDES
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851475445&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides, selected elements, and other chemicals in adult total diet samples, October 1978-September 1979.
AU - Gartrell, M. J.
AU - Craun, J. C.
AU - Podrebarac, D. S.
AU - Gunderson, E. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 5
SP - 862
EP - 875
AD - Gartrell, M. J.: Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19851475453. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - The dietary intake by adults of selected pesticides, industrial chemicals, and elements, including radionuclides, was estimated. The individual food items are separated into a number of food groups, each of which is analysed as a composite. This report summarizes the results for samples collected in 20 cities in USA between October 1978 and September 1979. The average and range of concentrations, and calculated average daily intake of each chemical found are presented. The average daily intakes of the chemicals are similar to those in the several preceding years and are within acceptable limits. Values for infants and toddlers are reported separately.
KW - adults
KW - contaminants
KW - Diets
KW - Pesticides
KW - RADIONUCLIDES
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851475453&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue method for determination of eight neutral β-lactam penicillins in milk by fluorescence-liquid chromatography.
AU - Munns, R. K.
AU - Shimoda, W.
AU - Roybal, J. E.
AU - Vieira, C.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 5
SP - 968
EP - 971
AD - Munns, R. K.: Food and Drug Administration, Animal Drug Research Center, 500 US Customhouse, Denver, CO 80202, USA.
N1 - Accession Number: 19851475479. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Dairy Science; Veterinary Science
N2 - For determination of total penicillin residues in milk, the sample (50 g) is incubated with penicillinase for 1 h at 37°C to hydrolyse the β-lactam ring, forming the respective penicilloate products. Milk proteins are removed by precipitation with acetonitrile, and fat is removed with methylene chloride. Addition of HgCl2 to aqueous milk extract results in the formation of penilloaldehydes from the penicilloates. The penilloaldehydes are extracted with methylene chloride, converted to their dansyl derivatives and analysed by liquid chromatography using 58% acetonitrile in water as mobile phase. Fluorescence is measured at 254 nm excitation wavelength with a 500 nm cut-off filter. The different penicillins can be identified from their retention times relative to a benzaldehyde internal standard. Recoveries of 8 penicillins added to milk at 25, 50 or 100 µg/kg are tabulated. Cloxacillins gave lowest recoveries of 26-37%, probably due to incomplete hydrolysis by penicillinase. Highest overall av. recovery was given by nafcillin (87.7%).
KW - Antibiotics
KW - assays
KW - Chemical analysis
KW - Cows
KW - detection
KW - Drug residues
KW - estimation
KW - Milk
KW - penicillins
KW - residues
KW - tissues
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851475479&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Overview of physical-chemical methods for determining aminoglycoside antibiotics in tissues and fluids of food-producing animals.
AU - Shaikh, B.
AU - Allen, E. H.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 5
SP - 1007
EP - 1013
AD - Shaikh, B.: Food and Drug Administration, Division of Veterinary Medical Research, Beltsville, MD 20705, USA.
N1 - Accession Number: 19851475482. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 76 ref. Registry Number: 1405-41-0, 1404-04-2, 57-92-1, 1403-66-3. Subject Subsets: Human Nutrition; Dairy Science; Veterinary Science
N2 - A survey of literature is presented dealing with physical-chemical methods for the detection and estimation of aminoglycoside antibiotics (gentamicin, streptomycin, dihydrostreptomycin and neomycin) that are used in food-producing animals. Recent developments in cleanup and determinative procedures, particularly liquid chromatography, for these compounds in fluids (including milk) and tissues are emphasized. Little research has been done on residues in tissues compared with other biological matrices. This review also covers the chemistry, general characteristics, tolerances, and withdrawal times for the approved uses of these antibiotics in animals that are used for food.
KW - Antibiotics
KW - assays
KW - Body fluids
KW - Chemical analysis
KW - chromatography
KW - Cows
KW - detection
KW - Drug residues
KW - estimation
KW - gentamicin
KW - Liquid chromatography
KW - Meat
KW - milk
KW - neomycin
KW - residues
KW - reviews
KW - Streptomycin
KW - tissues
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851475482&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control of chemical contaminants in foods: past, present, and future.
AU - Jelinek, C. F.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 6
SP - 1063
EP - 1068
AD - Jelinek, C. F.: Food and Drug Administration, Office of Physical Sciences, Washington, DC 20204, USA.
N1 - Accession Number: 19861478924. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
KW - contaminants
KW - Foods
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemical contaminants in foods: some analytical considerations.
AU - Burke, J. A.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 6
SP - 1069
EP - 1073
AD - Burke, J. A.: Food and Drug Administration, Division of Chemical Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19861478927. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
KW - contaminants
KW - Foods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861478927&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue method for quantitative determination of organophosphorus pesticides in foods.
AU - Blaha, J. J.
AU - Jackson, P. J.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1985///
VL - 68
IS - 6
SP - 1095
EP - 1099
AD - Blaha, J. J.: Food and Drug Administration, Total Diet Research Center, 1009 Cherry St., Kansas City, MO 64106, USA.
N1 - Accession Number: 19861478930. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - Foods
KW - organophosphorus compounds
KW - organic phosphorus compounds
KW - organophosphates
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861478930&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Splenotoxicity associated with splenic sarcomas in rats fed high doses of D & C Red No. 9 or aniline hydrochloride.
AU - Weinberger, M. A.
AU - Albert, R. H.
AU - Montgomery, S. B.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1985///
VL - 75
IS - 4
SP - 681
EP - 690
SN - 0027-8874
AD - Weinberger, M. A.: Division of Pathology, HFF-130, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19861480377. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - A histopathological review of F344 rat spleens from the USA, National Toxicology Program-National Cancer Institute bioassays of barium salt of 5-chloro-2-(2-hydroxy-1-naphthalenyl)-azo-4-methylbenzenesulphonic acid (D & C Red No. 9) and aniline HCl was made to assess splenotoxic changes associated with splenic sarcomas induced by those aromatic amines. Four splenic changes, fatty metamorphosis (FM), splenic fibrosis (FIB), capsule hyperplasia (CH) and haemorrhage, increased in incidence and severity in males treated with high doses of D and C Red No. 9 or aniline HCl. Females treated with high doses of either of those compounds showed similar but less severe changes. FIB and FM showed strong group correlations with tumour incidence. All groups which showed FM also had splenic tumours. The morphological similarity of the FIB and CH lesions to the induced splenic sarcomas suggests that those lesions are preneoplastic. The treatment-related splenic lesions seem to be precursors of the induced splenic sarcomas.
KW - aetiology
KW - amines
KW - Carcinoma
KW - spleen
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - causal agents
KW - etiology
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861480377&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice.
AU - Haseman, J. K.
AU - Huff, J. E.
AU - Rao, G. N.
AU - Arnold, J. E.
AU - Boorman, G. A.
AU - McConnell, E. E.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1985///
VL - 75
IS - 5
SP - 975
EP - 984
SN - 0027-8874
AD - Haseman, J. K.: Biometry and Risk Assessment Program, National Inst. Environmental Health Sciences, National Insts. Health, Public Health Service, US Dep. Health and Human Services, PO Box 12233, Mail drop B3-02, Research Triangle Park, NC 27709, USA.
N1 - Accession Number: 19861481156. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition; Maize
N2 - Control results with F344/N rats and (C57BL/6N X C3H/HeN)F1 (B6C3F1) mammary tumour virus-free mice from the USA, National Toxicology Program (NTP) were examined to determine if animals receiving maize oil by tube showed tumour incidences which differed from those of untreated controls. Analyses of those results were adjusted for interlaboratory variability, time-related trends and supplier effects. Two biologically significant effects were: male F344/N control rats receiving maize oil by tube showed a higher incidence of pancreatic acinar cell adenoma and a lower incidence of leukaemia (primarily mononuclear cell leukaemia) than did the corresponding untreated controls. The increased incidences of pancreatic acinar cell adenoma in male rats given maize oil by tube were associated with greater bodyweights in those animals relative to untreated controls. Female F344 rats and male and female B6C3F1 mice showed little or no evidence of a difference in tumour incidence between maize oil tube-treated and untreated controls. A review of nearly 300 carcinogenesis studies made by the USA, National Cancer Institute and the NTP showed that there was no maize oil tube study in which increased incidences of pancreatic acinar cell tumours or leukaemia in male F344/N rats were the only evidence of the carcinogenicity of a test chemical.
KW - development
KW - ingestion
KW - maize
KW - maize oil
KW - Neoplasms
KW - mice
KW - Muridae
KW - rats
KW - Zea mays
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - cancers
KW - corn
KW - corn oil
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861481156&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Financing nutrition services in a competitive market.
AU - Egan, M. C.
AU - Kaufman, M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1985///
VL - 85
IS - 2
SP - 210
EP - 215
SN - 0002-8223
AD - Egan, M. C.: Division of Maternal and Child Health, Bureau of Health Care Delivery and Assistance, Health Resources and Service Administration, Dep. Health and Human Services, Rockville, MD, USA.
N1 - Accession Number: 19851470179. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
KW - economics
KW - Nutrition
KW - services
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Economics (General) (EE100) (Discontinued June 2002)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851470179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin/mineral supplement use: a telephone survey of adults in the United States.
AU - Stewart, M. L.
AU - McDonald, J. T.
AU - Levy, A. S.
AU - Schucker, R. E.
AU - Henderson, D. P.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1985///
VL - 85
IS - 12
SP - 1585
EP - 1590
SN - 0002-8223
AD - Stewart, M. L.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19861481093. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - Vitamin/mineral supplement use in the USA was assessed through a national telphone interview survey of an age-stratified random sample of 2991 adults 16 years or older. A vitamin/mineral supplement was defined as any product containing one or more of 33 specific vitamins, minerals, or "miscellaneous dietary components". Excluding pregnant/lactating women, 39.9% of the population took one or more supplements. Of those, 52.4% took one supplement only; 10.9% took 5 or more (up to a maximum of 14 separate products). Above-average intake of supplements occurred in the western USA. The most widely taken product type was the single vitamin/miscellaneous dietary component (45.2% of supplement users). Vitamin C, alone or in combination with other nutrients, was the most widely taken nutrient (90.6% of supplement users). Use of supplements was more prevalent among women than among men in each of the 3 age groups examined: 16 to 24 years, 25 to 64 years and 65 years and older. Although intake of the B vitamins was more widespread among women than among men, more men than women took zinc, iodine, copper, magnesium and manganese. There was a wide range of intake of both vitamins and minerals, which extended to 10 to 50 times the Recommended Daily Allowances for individual nutrients.
KW - consumption
KW - Mineral supplements
KW - Vitamin supplements
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861481093&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intestinal absorption and lipoprotein transport of (ω-3) eicosapentaenoic acid.
AU - Chen, I. S.
AU - Subramaniam, S.
AU - Cassidy, M. M.
AU - Sheppard, A. J.
AU - Vahouny, G. V.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1985///
VL - 115
IS - 2
SP - 219
EP - 225
SN - 0022-3166
AD - Chen, I. S.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19851470277. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 10417-94-4. Subject Subsets: Human Nutrition
N2 - Adult male rats were surgically provided with a drainage catheter in the left thoracic lymphatic channel and an indwelling gastric catheter for constant infusion of saline-glucose. After overnight starvation, rats were given a single gastric dose of an aqueous emulsion containing one of the following 1-14C-labelled fatty acids: oleic, arachidonic or eicosapentaenoic acid, and [1,2-³H]cholesterol. Absorption was estimated by the appearance of radioactivity in lymph during a 24-h collection period, and the lymph lipoprotein distributions and lipoprotein lipid distribution were estimated in the 24-h samples. Although there were slight differences in the rates of eicosapentaenoic and arachidonic acid absorption, the overall appearance (after 24 h) of those acids in lymph was quantitatively equivalent to that of oleate. Cholesterol absorption from each fatty acid medium was quantitatively similar. The distributions of each fatty acid among major lymph lipoproteins were similar with 93 to 95% recovered in chylomicrons and very-low-density lipoprotein (VLDL) fractions. In VLDL, 85 to 91% of each of the 3 fatty acids was recovered as triglycerides. With both polyunsaturated fatty acids, there was greater incorporation into phospholipids and their precursor partial glycerides than with oleate. These studies suggest that unesterified eicosapentaenoic acid is absorbed efficiently into the lymphatic system.
KW - Eicosapentaenoic acid
KW - metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851470277&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Loss of vitamin A in long-term stored, frozen sera.
AU - Driskell, W. J.
AU - Bashor, M. M.
AU - Neese, J. W.
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 1985///
VL - 147
IS - 1
SP - 25
EP - 30
SN - 0009-8981
AD - Driskell, W. J.: Nutritional Biochemistry Branch, Clinical Chemistry Division, Center for Environmental Health (CEH), Centers for Disease Control (CDC), Public Health Service, U.S. Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19851471073. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition
N2 - Vitamin A was measured by a high-performance liquid chromatography (HPLC) method in human serum samples stored at -20°C for 2-6 years. In 40% of the samples, both vitamin A and the internal standard, retinyl acetate, were destroyed. Controlled studies of each phase of the method showed that vitamin A began to degrade during the extraction step immediately after ethanol was added to the serum. Vitamin E and β-carotene also degraded concurrently with vitamin A. Vitamin A may be lost because of free radical oxidation after the vitamin is released from retinol-binding protein, after ethanol is added to the sample. The loss of vitamin A is eliminated completely if ascorbic acid (0.1% w/v) is added to the ethanol before extraction.
KW - Blood
KW - losses
KW - RETINOL
KW - storage
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19851471073&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selective defects in cytomegalovirus- and mitogen-induced lymphocyte proliferation and interferon release in patients with acquired immunodeficiency syndrome.
AU - Epstein, J. S.
AU - Frederick, W. R.
AU - et al.
AU - Rook, A. H. (
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1985///
VL - 152
IS - 4
SP - 727
EP - 733
SN - 0022-1899
AD - Epstein, J. S.: Office of Biologics Research and Review, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20205, USA.
N1 - Accession Number: 19862028648. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - To examine the defect in cellular immunity in patients with acquired immunodeficiency syndrome (AIDS), we studied in vitro lymphocyte proliferation and interferon (IFN) release in response to cytomegalovirus (CMV) antigen and Concanavalin A mitogen in 40 homosexual men with AIDS, 10 homosexual men with chronic lymphadenopathy syndrome, 7 healthy homosexual men, and 18 healthy heterosexual subjects of either sex. CMV serology by an enzyme-linked immunosorbent assay and viral cultures for CMV were performed. Lymphocytes of patients with AIDS showed impaired CMV-specific release of IFN but normal mitogen-induced IFN release. The defect was not attributable to CMV infection per se. Cell proliferation in response to both CMV antigen and mitogen was impaired in patients with AIDS who had opportunistic infections. The defect could not be attributed to CMV viremia. We concluded that impaired release of IFN in response to a viral antigen is characteristic of lymphocytes in patients with AIDS and that this defect is distinct from a defect in mitogenic responsiveness, which coexists predominantly in patients with opportunistic infections.AS
KW - Acquired immune deficiency syndrome
KW - immunology
KW - lymphocyte transformation
KW - AIDS
KW - AIDS immune system
KW - selective defects
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862028648&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Suppression of antibody response by excess dietary zinc exposure during certain stages of ontogeny.
AU - Mulhern, S. A.
AU - Vessey, A. R.
AU - Taylor, G. L.
AU - Magruder, L. E.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1985///
VL - 180
IS - 3
SP - 453
EP - 461
SN - 0037-9727
AD - Mulhern, S. A.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19861480573. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7440-66-6. Subject Subsets: Human Nutrition
N2 - A study was made of the effects of excess dietary zinc on the antibody response to sheep red blood cells (SRBC) in mice. C57BL/6J mice in 10 groups were given diets containing Zn in normal (50 μg/g) or excess (2000 μg/g) concentrations during gestation/lactation/postweaning development in the sequences 50/50/50; 50/50/2000; 2000/50/50; 2000/2000/50; 2000/50/2000; 50/2000/50; 50/2000/2000; 2000/2000/2000; 50/50/50; (pair-fed); and chow/chow/chow. Mice given 2000 μg/g throughout had severe signs of copper deficiency at 8 weeks old, such as reduced plasma Cu, lowered plasma haematocrit, and achromotrichia. Mice given Zn 2000 μg/g during gestation had fewer offspring per litter at 2 weeks of age and more non-viable births than mice given Zn 50 μg/g during gestation. The growth curve of mice given 50/50/2000 was identical to that of those given 50 μg/g throughout. Growth curves for all other groups were reduced by varying amounts. The plaque-forming cell response to SRBC was reduced only in the groups given Zn 50/2000/2000 and 2000/2000/2000 μg/g; this reduced response was not associated with atrophy of the lymphoid organs. Splenic cell surface markers and mitogenic responsiveness were normal with 2000 μg/g throughout. These results suggest that the immune response is more susceptible to dietary manipulation during development than after the immune response has been developed.
KW - antibody formation
KW - loads
KW - Zinc
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861480573&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary protein on growth and on plasma and liver vitamin A and E levels in young rats.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1986///
VL - 6
IS - 9
SP - 1083
EP - 1094
SN - 0271-5317
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19871491775. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition; Soyabeans
N2 - The effects of dietary protein sources on rat plasma and liver vitamin A and E values were studied in male weanling rats fed on purified 20% protein diets for 28 days. Diets contained adequate amounts of all vitamins and minerals. The food efficiency values expressed as percentages of ANRC casein ranged from 85 to 99 with the exception of liver powder, which was 45. The liver vitamin A concentrations ranged from 131 to 320 μg/g. The liver vitamin A concentrations were higher for soya isolate, soya flour, blue-green algae (BGA) and liver powder than for ANRC casein. The high-lactose whey group had the lowest vitamin A concentrations; liver powder had the highest. The liver vitamin E concentrations ranged from 42 to 96 μg/g. The liver vitamin E values with all protein sources, except wheat-milk and milk-egg-BGA, were lower than for ANRC casein. Liver vitamin E values for textured soya protein, low-lactose whey and BGA were about 47% lower than for soya isolate, high-lactose whey and milk-egg-BGA, respectively. ANRC casein had the highest plasma vitamin A and E concentrations. Milk-egg-BGA, liver powder and BGA caused the greatest reductions in plasma vitamin E, 48, 59 and 88%, respectively, suggesting that food processing and/or protein matrices may possibly affect liver and plasma vitamin A and E concentrations.
KW - blood
KW - Growth
KW - liver
KW - protein sources
KW - RETINOL
KW - soya protein
KW - soyabean flour
KW - Vitamin E
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - soy protein
KW - soyabean protein
KW - soybean flour
KW - soybean protein
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Food Composition and Quality (QQ500)
KW - QQ050 (QQ050) Unknown Subject
KW - Crop Produce (QQ050)
KW - Animal Nutrition (General) (LL500)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871491775&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Restoration of immunoregulation in splenic lymphocyte populations of mice fed reduced dietary protein.
AU - Petro, T. M.
AU - Smith, B. G.
AU - Raybourne, R.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1986///
VL - 6
IS - 11
SP - 1293
EP - 1305
SN - 0271-5317
AD - Petro, T. M.: Food and Drug Administration, Division of Microbiology, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19871492522. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - Moderate, acute reduction of dietary protein in young mice often results in an increase in humoral immune response. To test the hypothesis that reduction of dietary protein affects T-lymphocyte regulation of the humoral immune response, humoral immune responses in vitro to sheep erythrocytes (SRBC) and bromelain-treated mouse erythrocytes (BrMRBC), were examined in BDF1 and BALB/c mice fed on diets low in protein (4 or 6% casein) compared with well-fed (20% casein) controls. The immunoregulatory splenic T-lymphocyte subset profile was evaluated in mice fed on the 4 and 20% casein diets. Groups of female BDF1 and BALB/c mice 5 weeks old were fed on one of the 3 diets for 5 weeks. Mice fed on the 4% casein diet had lower body weights and splenic lymphocyte numbers than mice from the other 2 groups. BDF1 but not BALB/c mice fed on the 4% casein diet had significantly increased immune responses in vitro and in vivo to optimum or high doses of SRBC. BDF1 and BALB/c mice fed on the 4% casein diet had a significantly higher immune response to BrMRBC. The increased response of 4% casein-fed BDF1 mice was related to an inability to generate adequate specific immunoregulatory T cells involved in suppressing the response. Co-culturing with Lyt1+ or Lyt2+ T cells from well-fed mice regulated downwardly the increased autoimmune, anti-BrMRBC response of mice given the 4% casein diet. Decreased suppressor T lymphocyte activity in BDF1 mice, but not BALB/c mice fed on the 4% casein diet was confirmed by the significant depression of the Lyt2+ suppressor T cell number in the spleen evaluated by direct immunofluorescence using monoclonal antibodies which identify T-lymphocyte subsets.
KW - IMMUNE RESPONSE
KW - protein deficiencies
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immunity reactions
KW - immunological reactions
KW - protein malnutrition
KW - Animal Models of Human Nutrition (VV140)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871492522&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of fatty acids in butter fat using temperature-programmed gas chromatography of the butyl esters.
AU - Iverson, J. L.
AU - Sheppard, A. J.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1986///
VL - 21
IS - 3
SP - 223
EP - 234
SN - 0308-8146
AD - Iverson, J. L.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19861488516. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Substituting butanol for methanol specified in the AOAC Official methods of analysis (sections 28.056-28.059) permitted complete recovery of the butyl esters of volatile short-chain acids. The esters were estimated using a continuous multistage temperature-programmed gas chromatographic method, with a 10% apolar 10C column. The values for 50 butters in 1982 were similar to those for 30 butters analysed in 1974. A urea fractionation technique was used to concentrate minor components for identification and estimation.
KW - chromatography
KW - Cows
KW - determination
KW - estimation
KW - fatty acids
KW - gas chromatography
KW - Milk fat
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - butterfat
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861488516&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phosphorus-31 nuclear magnetic resonance spectroscopic determination of phytate in foods.
AU - Mazzola, E. P.
AU - Phillippy, B. Q.
AU - Harland, B. F.
AU - Miller, T. H.
AU - Potemra, J. M.
AU - Katsimpiris, E. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1986///
VL - 34
IS - 1
SP - 60
EP - 62
SN - 0021-8561
AD - Mazzola, E. P.: Food and Drug Administration, Division of Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19861481497. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 83-86-3. Subject Subsets: Human Nutrition
KW - estimation
KW - Foods
KW - phytic acid
KW - inositol hexaphosphate
KW - phytate
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861481497&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sex specificity of myocardial damage in mice fed a purified diet.
AU - Fullerton, F. R.
AU - Greenman, D. L.
AU - Kushmaul, R. J.
JO - Laboratory Animal Science
JF - Laboratory Animal Science
Y1 - 1986///
VL - 36
IS - 6
SP - 650
EP - 654
SN - 0023-6764
AD - Fullerton, F. R.: Dep. Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19881406549. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - For 90 days BALB/c and B6C3F1 mice were given a purified diet (AIN-76A) or a natural ingredient diet (NIH-07) containing 2-acetylaminofluorine, 0, 25, 50, 75 or 100 mg/kg for males and 0, 50, 100, 150 or 200 mg/kg for females. A large number of dead or moribund B6C3F1 males given the AIN diet were removed from the study prematurely. These mice, and some AIN-fed B6C3F1 mice killed at the end of the study, showed myocardial damage with haemorrhage. A small number of BALB/c males given the AIN diet also showed these signs, while none of the females from either strain were affected. There was no evidence of specific pathogens, nutritional deficiencies or environmental factors that could have caused those lesions. However, there may have been an association with extended storage (up to 4 months) and one particular batch of feed.
KW - Heart diseases
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - coronary diseases
KW - purified diets
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881406549&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Feeding neophobia: a possible explanation for the differential maze performance of rats reared in enriched or isolated environments.
AU - Holson, R. R.
JO - Physiology and Behavior
JF - Physiology and Behavior
Y1 - 1986///
VL - 38
IS - 2
SP - 191
EP - 201
AD - Holson, R. R.: Division of Reproductive and Developmental Toxicology, HFT-133, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19861489855. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - Three male rats, littermates from each of 19 litters were exposed to early and lengthy environmental enrichment, isolation or isolation plus frequent handling. At 120 days old they were tested on the open field, on an emergence task and in a complex maze. They were allowed to enter and leave the maze goal box at will. Only after eating for 30 s were they captured and replaced in the start box for the next trial. In the open field and emergence tasks the enriched and isolate rats both showed signs of greater timidity than the experimenter-adapted handled rats. In the maze, enriched rats increased goal box entries over days, handled and non-handled isolates did not. By day 3, handled and non-handled isolate goal entries were significantly lower than for enriched rats. This finding suggests an intellectual deficit in isolate maze learning. Error analysis revealed that even on day one, all groups made errors at a rate far below random. The pattern of errors implied that rats were often actively avoiding the goal, with isolates turning aside before entering the goal significantly more often than enriched rats. These findings suggest that the isolate maze deficit is due to a form of feeding neophobia. More generally, it would seem that these behavioural differences reflect early learning, with handled rats less afraid of humans and enriched rats better adapted tp eating in novel surroundings.
KW - behaviour
KW - environmental factors
KW - Feeding behaviour
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - feeding behavior
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861489855&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimating soil ingestion: the use of tracer elements in estimating the amount of soil ingested by young children.
AU - Binder, S.
AU - Sokal, D.
AU - Maughan, D.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 1986///
VL - 41
IS - 6
SP - 341
EP - 345
SN - 0003-9896
AD - Binder, S.: Division of Environmental Hazards and Health Effects, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19871497552. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - In a pilot study, methods used in estimating the amount of soil ingested by ruminants were modified to measure soil ingested by children. Using aluminium, silicon and titanium as tracers, soil ingestion was estimated for 59 children 1 to 3 years old from East Helena, MT, USA. Estimated daily soil ingestion based on Al and Si concentrations were 181 and 184 mg daily, respectively, whereas the estimate based on the Ti concentration was about 10 times higher, 1834 mg daily. Although it is not considered that those estimates are accurate measures of soil ingestion, the method is a reasonable approach which has not been used before in man. However, the estimates are to be revised as refinement of the method and better understanding of the metabolism of Al, Si and Ti give more accurate results for analysis.
KW - Children
KW - estimation
KW - soil ingestion
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871497552&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alopecia induced in young mice by exposure to excess dietary zinc.
AU - Mulhern, S. A.
AU - Stroube, W. B., Jr.
AU - Jacobs, R. M.
JO - Experientia
JF - Experientia
Y1 - 1986///
VL - 42
IS - 5
SP - 551
EP - 553
SN - 0014-4754
AD - Mulhern, S. A.: Division of Nutrition, Food and Drug Administration, 200 C Street SW, Washington DC 20204, USA.
N1 - Accession Number: 19861486348. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7440-66-6. Subject Subsets: Human Nutrition
N2 - Second generation mice were exposed to normal (50 μg/g, Group 1) or excess (2000 μg/g, Group 2) zinc in the maternal diet during gestation and lactation, then were weaned and continued on the mother's diet until sacrifice at 8 weeks. Zn in tibia reflected dietary intake. Group 2 had reduced plasma copper, body weight and haematocrit; the second coat of hair appeared late and was lighter in colour than in Group 1, possible as an effect of Cu and pigmentation development and hair growth.
KW - aetiology
KW - alopecia
KW - loads
KW - Zinc
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - causal agents
KW - etiology
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861486348&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dimensions of the issue of explicit health claims on food labels.
AU - Forbes, A. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986///
VL - 43
IS - 4
SP - 629
EP - 635
SN - 0002-9165
AD - Forbes, A. L.: Office of Nutrition and Food Sciences (HFF-200), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19861484611. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition
KW - Foods
KW - labelling
KW - lectures
KW - labeling
KW - labels
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861484611&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The regulatory perspective of diet-behavior relationships.
AU - Sobotka, T. J.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1986///
VL - 44
SP - 241
EP - 246
SN - 0029-6643
AD - Sobotka, T. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19861486238. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
KW - Behaviour
KW - diets
KW - reviews
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861486238&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Status of data sources on fish consumption in the United States.
AU - Wagstaff, D. J.
AU - Meaburn, M.
AU - Bolger, M.
AU - Conrath, S.
AU - Hackley, B.
JO - Marine Fisheries Review
JF - Marine Fisheries Review
Y1 - 1986///
VL - 48
IS - 3
SP - 20
EP - 23
AD - Wagstaff, D. J.: Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891411968. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - Despite the importance of information on fish consumption in USA to decisions in public health, law and business, much of the information is poorly documented. This brief report documents the existence and characteristics of available data sources and evaluates the strength and limitations of each data source.
KW - Fish consumption
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411968&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methylmercury in fish: a review of residue levels, fish consumption and regulatory action in the United States.
AU - Tollefson, L.
AU - Cordle, F.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 1986///
VL - 68
IS - Sept.
SP - 203
EP - 208
SN - 0091-6765
AD - Tollefson, L.: Epidemiology and Clinical Toxicology Unit, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19871401976. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7439-97-6, 593-74-8. Subject Subsets: Public Health; Human Nutrition
N2 - The toxicokinetics of methylmercury in man are reviewed and used to estimate body burdens associated with toxic effects. To determine seafood consumption patterns among the continental population of the USA the Food and Drug Administration (FDA) has analysed data from a diary study commissioned by the Tuna Research Foundation. Mercury residues in domestic fish sampled by the FDA were used to determine exposure to methylmercury. Until evidence is presented that substantially lowers the known body burden of methylmercury which causes toxicity, calculations indicate that the current value of 1.0 μg/g provides adequate protection for the average fish consumer, for young children and for a significant number of consumers exceeding the acceptable daily intake. However, additional studies are being made to ensure that safe levels of prenatal exposure to Hg residues in fish are maintained.
KW - fish
KW - Food
KW - Mercury
KW - methylmercury
KW - reviews
KW - North America
KW - USA
KW - Fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871401976&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reevaluation of Monier-Williams method for determining sulfite in food.
AU - Warner, C. R.
AU - Daniels, D. H.
AU - Joe, F. L., Jr.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 1
SP - 3
EP - 5
AD - Warner, C. R.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19861485495. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - Foods
KW - SULFITES
KW - sulphites
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485495&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thin layer chromatographic determination of deoxynivalenol in processed grain products.
AU - Trucksess, M. W.
AU - Flood, M. T.
AU - Page, S. W.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 1
SP - 35
EP - 36
AD - Trucksess, M. W.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19861485500. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 51481-10-8. Subject Subsets: Human Nutrition; Maize; Wheat, Barley & Triticale Abstracts
KW - Cereal products
KW - Cereals
KW - estimation
KW - products
KW - vomitoxin
KW - deoxynivalenol
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485500&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thin layer chromatographic method for determination of deoxynivalenol in wheat: collaborative study.
AU - Eppley, R. M.
AU - Trucksess, M. W.
AU - Nesheim, S.
AU - Thorpe, C. W.
AU - Pohland, A. E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 1
SP - 37
EP - 40
AD - Eppley, R. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19861485501. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 51481-10-8. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts
KW - estimation
KW - vomitoxin
KW - Wheat
KW - Triticum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - deoxynivalenol
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485501&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1980-March 1982.
AU - Gartrell, M. J.
AU - Craun, J. C.
AU - Podrebarac, D. S.
AU - Gunderson, E. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 1
SP - 123
EP - 145
AD - Gartrell, M. J.: Food and Drug Administration, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19861485510. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition
N2 - The USA Food and Drug Administration conducts Total Diet Studies to determine the dietary intake of selected chemicals. These studies involve the retail purchase and analysis of representative foods. The individual food items are separated into a number of food groups, each of which is analysed as a composite. This report summarizes the results for infant and toddler samples collected in 13 cities between October 1980 and March 1982. The average concentration, range of concentrations and calculated average daily intake of each chemical are presented by food group. The average daily intakes of the chemicals are similar to those in the several preceding years and generally are within acceptable limits. The results for samples representing the adult diet are reported separately.
KW - Children
KW - contaminants
KW - diets
KW - Infants
KW - pesticides
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485510&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides, selected elements, and other chemicals in adult total diet samples, October 1980-March 1982.
AU - Gartrell, M. J.
AU - Craun, J. C.
AU - Podrebarac, D. S.
AU - Gunderson, E. L.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 1
SP - 146
EP - 159
AD - Gartrell, M. J.: Food and Drug Administration, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19861485512. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - The USA Food and Drug Administration conducts Total Diet Studies to determine the dietary intake of selected chemicals. These studies involve the retail purchase and analysis of representative foods. The individual food items are separated into a number of food groups, each of which is analysed as a composite. This report summarizes the results for adult samples collected in 27 cities between October 1980 and March 1982. The average concentrations, range of concentrations, and calculated average daily intake of each chemical are presented by food group. The average daily intakes of the chemicals are similar to those in the several preceding years and are within acceptable limits. The results for samples representing the diets of infants and toddlers are reported separately.
KW - Adults
KW - contaminants
KW - diets
KW - pesticides
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861485512&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sulfite in food by flow injection analysis.
AU - Sullivan, J. J.
AU - Hollingworth, T. A.
AU - Wekell, M. M.
AU - Newton, R. T.
AU - Larose, J. E.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 3
SP - 542
EP - 546
AD - Sullivan, J. J.: Food and Drug Administration, Seafood Products Research Center, Seattle, WA 98174, USA.
N1 - Accession Number: 19861490168. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - Foods
KW - SULFITES
KW - sulphites
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861490168&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic determination of fatty acids and sterols in orange juice.
AU - Stack, J. B.
AU - Joe, F. L., Jr.
AU - Cunningham, D. G.
AU - Fazio, T.
AU - Roach, J. A. G.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 3
SP - 551
EP - 556
AD - Stack, J. B.: F.L. Joe, Jr., Food and Drug Administration, Division of Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19861490169. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Seven main fatty acids and 5 sterols were estimated in orange juice by the described gas chromatographic method. The precision was 7% and recoveries were 83-113%. The compounds of interest were in the 1.3-72.0 mg/litre range.
KW - estimation
KW - fatty acids
KW - Orange juice
KW - sterols
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861490169&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current trends in levels of volatile N-nitrosamines in fried bacon and fried-out bacon fat.
AU - Canas, B. J.
AU - Havery, D. C.
AU - Joe, F. L., Jr.
AU - Fazio, T.
JO - Journal of the Association of Official Analytical Chemists
JF - Journal of the Association of Official Analytical Chemists
Y1 - 1986///
VL - 69
IS - 6
SP - 1020
EP - 1021
AD - Canas, B. J.: Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19871494374. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Volatile N-nitrosamines have been estimated in fried processed bacon purchased in Washington, DC, since 1971. A downward trend in the concentration of N-nitrosopyrrolidine was observed, and between 1978 and 1980 was maximum at 4 to 30, average 11 ng/g. A recent survey, however, indicates a change in this downward trend, with N-nitrosopyrrolidine 1 to 65, average 21 ng/g. Volatile N-nitrosamines were up to 110 ng/g in the fried product and up to 85 ng/g in the fried-out bacon fat.
KW - Bacon
KW - nitrosamines
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871494374&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mineral content of foods and total diets: the Selected Minerals in Foods Survey, 1982 to 1984.
AU - Pennington, J. A. T.
AU - Young, B. E.
AU - Wilson, D. B.
AU - Johnson, R. D.
AU - Vanderveen, J. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1986///
VL - 86
IS - 7
SP - 876
EP - 891
SN - 0002-8223
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19861487088. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The 234 foods of the Food and Drug Administration's Total Diet Study were collected 4 times a year from mid-1982 to mid-1984 and analysed for 11 essential minerals. Daily intakes of the minerals were estimated for 8 age-sex groups of the USA population. Amounts of calcium, magnesium, iron, zinc, copper and manganese were low, less than 80% of the recommended dietary allowance (RDA) or below the low end of the Estimated Safe and Adequate Daily Dietary Intake (ESADDI), for some or all age-sex groups. Those most at risk of low intakes were young children, teenage girls, adult women and older women. Non-discretionary sodium intake exceeded the upper ESADDI range for 2 age-sex groups, and iodine was considerably above the RDA for all age-sex groups. Amounts of potassium, phosphorus and selenium were adequate for all groups.
KW - intake
KW - Minerals
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861487088&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition in American Indian health: past, present, and future.
AU - Jackson, M. Y.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1986///
VL - 86
IS - 11
SP - 1561
EP - 1565
SN - 0002-8223
AD - Jackson, M. Y.: Nutrition and Dietetics Section, Indian Health Service, Rockville, MD, USA.
N1 - Accession Number: 19871491690. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition
N2 - In addition to benefiting from public health programmes for all Americans, American Indians and Alaska Natives are eligible for health services from the Indian Health Service (IHS), US Public Health Service. IHS provides comprehensive health services, including nutrition and dietetics, to American Indians and Alaska Natives living on or near federal Indian reservations or in traditional Indian territory, such as Oklahoma and Alaska. Dramatic improvements have occurred in the health of native Americans since IHS was transferred to the Public Health Service in 1955. Infant mortality rate, maternal deaths and deaths related to infectious diseases have all decreased. Chronic diseases are now major causes of death. Nutritional factors contribute to at least 4 of the 10 leading causes of American Indian and Alaska Native deaths, heart disease, cancer, cirrhosis and diabetes, and to the prevalence of overweight, obesity, hypertension and dental caries. There is still incomplete information on nutritional state and present dietary patterns, nutritive value of native foods, and nutrition education knowledge of the population. Priority nutrition objectives have been developed to address those issues.
KW - Ethnic groups
KW - health
KW - nutrition
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871491690&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of taste in dietary self-selection in rats.
AU - Miller, M. G.
AU - Teates, J. F.
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
Y1 - 1986///
VL - 100
IS - 3
SP - 399
EP - 409
SN - 0735-7044
AD - Miller, M. G.: Center for Food Safety and Applied Nutrition, HFF-265, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19861487529. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - To study the role of taste in dietary self-selection 48 male albino rats were subjected to 2 degrees of gustatory deafferentation. The chorda tympani was sectioned alone or with the glossopharyngeal nerve and the pharyngeal branch of the vagus. The rats chose from 2 diets, only one of which contained protein. After surgery, deficits were observed in body weight, food and water intake, and diet selection, proportional to the extent of deafferentation. Of the rats 76% increased protein and decreased carbohydrate intake, but all continued to select a nutritionally balanced diet. When subjected to a nutritional challenge of intragastric protein or carbohydrate supplements, the rats compensated for energy and nutrients by selectively adjusting oral intake. In saccharin preference tests, the preference as well as the total intake of the test solutions was reduced. The different roles/mechanisms of the 2 sensory systems with regard to dietary self-selection are discussed.
KW - Food preferences
KW - roles
KW - taste
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet preferences
KW - taste preferences
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19861487529&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Purified reference diets for weanling rats: effects of biotin and cellulose.
AU - Rader, J. I.
AU - Wolnik, K. A.
AU - Gaston, C. M.
AU - Fricke, F. L.
AU - Fox, M. R. S.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1986///
VL - 116
IS - 9
SP - 1777
EP - 1788
SN - 0022-3166
AD - Rader, J. I.: Division of Nutrition, Food and Drug Administration (FDA), Washington, DC 20204, USA.
N1 - Accession Number: 19871491875. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9004-34-6, 58-85-5. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - A biotin- and cellulose-free diet of reproducible mineral composition (diet A), based on diet AIN-76, was formulated and given to weanling Long-Evans rats for 3 weeks. Inductively coupled argon plasma atomic emission spectrometry was used to estimate major and trace elements in liver, duodenum, kidney, spleen and femur. Results were compared with those obtained with rats fed on biotin- and/or cellulose-supplemented variations of diet A, diet AIN-76 and diet NIH-31 (an open-formula stock diet). Weanling rats grew slowly and steadily on purified diet A. Growth rates increased when diet A was supplemented with biotin and cellulose. In general, differences among tissue mineral values in rats fed on diet NIH-31 and those on diet AIN-76 were more pronounced than those among groups fed on the test purified diets. Values for haemoglobin and haematocrit were significantly lower in rats fed on all purified diets than in those fed on NIH-31. Diets A + biotin, A + cellulose and A + cellulose + biotin seem satisfactory as reference diets for measuring mineral interactions at near-requirement values as well as effects of fibre on mineral utilization or for studies on vitamins the endogenous synthesis of which may be influenced by dietary fibre.
KW - biotin
KW - Cellulose
KW - deficiency
KW - diets
KW - vitamin deficiencies
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Food Composition and Quality (QQ500)
KW - Animal Nutrition (Production Responses) (LL520)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871491875&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of health aspects of sugars contained in carbohydrate sweeteners. Report of Sugars Task Force, 1986.
AU - Glinsmann, W. H.
AU - Irausquin, H.
AU - Park, Y. K.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1986///
VL - 116
SP - S1
EP - S216
SN - 0022-3166
AD - Glinsmann, W. H.: Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19871494764. Publication Type: Journal Article. Language: English. Number of References: 922 ref. Subject Subsets: Human Nutrition
N2 - Estimates of present levels of sugar intake in the USA and of recent trends in nutritive carbohydrate sweetener content of the food supply are reviewed together with recent scientific literature addressing potentially adverse health effects associated with sugar consumption. Several conclusions are drawn, among which are the following: Although eating high-sugar diets may produce adverse effects on glucose tolerance and insulin metabolism, there is no persuasive scientific evidence that sugars at current levels of intake in the USA are an independent risk factor for the development of impaired glucose tolerance. Although there is evidence to support the existence of a subset of "carbohydrate-sensitive" males who have Type IV hyperlipoproteinaemia and an increased insulin response to oral sucrose loads, the existence of a unique risk to this population from carbohydrate sweeteners has not been established. The concept that dietary mono- and disaccharides contribute to glycaemia more than starches is not supported by recent studies which show that glycaemic responses to carbohydrate-containing foods vary according to food source, method of food preparation, meal pattern, the presence of other dietary constituents and physical activity. Current levels of consumption of sugars have not been shown to be an adverse risk factor in terms of blood lipid and lipoprotein profiles for normal persons. There is no conclusive evidence that dietary sugars are an independent risk factor for coronary artery disease in the general population. The theoretical possibility that dietary sugars modify behaviour through effects on neurotransmitter metabolism in the central nervous system has not been documented. The available information supports the conclusion that sugars do not have a unique role in the aetiology of obesity. Evidence exists that sugars as they are consumed in the average American diet contributes to the development of dental caries. Overall, apart from contributing to dental caries, there is no conclusive evidence to show that sugars at their present levels and manner of intake are a hazard to the general public.
KW - health
KW - intake
KW - reviews
KW - Sugars
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871494764&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology of AIDS retrovirus in South Australia.
AU - Ross, M. W.
AU - Cameron, A. S.
T2 - Medical Journal of Australia
JO - Medical Journal of Australia
JF - Medical Journal of Australia
Y1 - 1986///
VL - 144
IS - 11
SP - 614
EP - 615
SN - 0025-729X
AD - Ross, M. W.: AIDS Programme, Public Health Service, South Australian Health Commission, PO Box 65, Rundle Mall, South Australia 5000, Australia.
N1 - Accession Number: 19862034203. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health
N2 - By mid-January 1986 intravenous drug abusers accounted for only 1.4% of AIDS patients in Australia but analysis of the results of the first 9 months of screening in South Australia (to the end of December 1985) indicates that HIV may have penetrated the drug subculture there earlier than it did the male homosexual community and indeed may have entered the continent through drug abusers. Confirmed positive results for HIV antibodies were obtained in 90 of nearly 6000 sera. Of these 90, 22 were from drug abusers, 60 from homosexual and bisexual men with a further 3 from homosexual male drug abusers, 7 transfusion and blood product recipients and 1 person with no known risk factors; 5 of the seropositives were women. South Australia does not appear to have a greater prevalence of i.v. drug abuse than the rest of Australia. No case of AIDS was noted in the state. Over one-third of the seropositives were identified by the AIDS programme and one-fifth each by hospitals and general practitioners (44% of this latter group came from Sydney after legislation in New South Wales requiring notification of positive results and suggestions of legal sanctions).D.W. FitzSimons
KW - acquired immune deficiency syndrome
KW - Epidemiology
KW - HIV infections
KW - homosexuality
KW - injecting drug users
KW - men
KW - Screening
KW - Transmission
KW - Australasia
KW - Australia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Oceania
KW - APEC countries
KW - Australasia
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - AIDS
KW - homosexuals
KW - human immunodeficiency virus infections
KW - i.v. drug abusers
KW - i.v. drug users
KW - intravenous drug users
KW - screening tests
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19862034203&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Thin-layer chromatography/high performance thin-layer chromatography as a tool for mycotoxin determination.
AU - Nesheim, S.
AU - Trucksess, M. W.
A2 - Cole, R. J.
T2 - Modern methods in the analysis and structural elucidation of mycotoxins.
JO - Modern methods in the analysis and structural elucidation of mycotoxins.
JF - Modern methods in the analysis and structural elucidation of mycotoxins.
Y1 - 1986///
SP - 239
EP - 264
CY - Orlando, Florida; USA
PB - Academic Press, Inc.
SN - 0121795152
AD - Nesheim, S.: Food and Drug Administration, Division of Chemistry and Physics, Washington, DC 20204, USA.
N1 - Accession Number: 19901206197. Publication Type: Miscellaneous. Language: English. Number of References: 91 ref. Registry Number: 518-75-2, 10048-13-2, 17924-92-4, 149-29-1, 90-65-3. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology
N2 - The application of thin-layer chromatographic procedures to the determination of mycotoxins is discussed and examples are presented for individual mycotoxins, including aflatoxins, ochratoxins, citrinin, sterigmatocystin, zearalenone, trichothecenes, patulin and penicillic acid.
KW - Aflatoxins
KW - biodeterioration
KW - Citrinin
KW - estimation
KW - Mycotoxins
KW - Ochratoxins
KW - Patulin
KW - Penicillic acid
KW - reviews
KW - Sterigmatocystin
KW - thin layer chromatography
KW - Trichothecenes
KW - Zearalenone
KW - f-2 toxin
KW - fungal toxins
KW - Biodeterioration (SS300)
KW - Plant Composition (FF040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Cadmium absorption, distribution and excretion in young and adult miniature swine.
AU - Sapienza, P. P.
AU - Ikeda, G. J.
AU - Miller, E.
A2 - Tumbleson, M.E.
T2 - Swine in biomedical research. Volume 2
JO - Swine in biomedical research. Volume 2
JF - Swine in biomedical research. Volume 2
Y1 - 1986///
SP - 1077
EP - 1084
CY - New York; USA
PB - Plenum Press
AD - Sapienza, P. P.: Food and Drug Administration, Division of Toxicology, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19871400566. Publication Type: Miscellaneous. Language: English. Number of References: 6 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition; Pig Science
N2 - For 14 days a group of 15 miniature piglets 4 weeks old and a group of 15 adult miniature pigs more than 6 months old were given by mouth Cd 1.5 mg/kg daily as cadmium chloride dissolved in water. Groups of 5 adults and piglets were killed at 0, 1 and 4 weeks from end of Cd treatment. In adults and piglets Cd absorption was about 2% of total Cd given and appeared mainly in liver and kidney. Initially (week 0) 17 and 14% of Cd given was retained in the intestines of adults and piglets but 1 week after the final treatment with Cd retention was reduced to 1.3 and 1.8% of total amount of Cd given. At week 4 after final Cd treatment 90 and 93% of total Cd given was excreted in faeces of adults and piglets. There were no differences in absorption or tissue distribution patterns of Cd between adult miniature pigs and miniature piglets. The results may be extrapolated to man.
KW - Cadmium
KW - metabolism
KW - Miniature pigs
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hogs
KW - minipigs
KW - swine
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (General) (LL500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thymus derived (T) lymphocyte subsets restore the immune responsiveness of Peyer's patch lymphocytes from mice fed a diet reduced in protein.
AU - Petro, T. M.
AU - Wess, J. A.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1987///
VL - 7
IS - 9
SP - 935
EP - 946
SN - 0271-5317
AD - Petro, T. M.: Division of Microbiology, Food and Drug Administration, 1090 Tusculum Ave., Cincinnati, OH 45226, USA.
N1 - Accession Number: 19871401693. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - The main immunoglobulin (Ig) that inhibits absorption of intact dietary protein and microbial colonization of the small intestine is secretory IgA produced by lamina propria plasma cells terminally differentiated from B lymphocytes of the Peyer's patches (PP). To determine the effect of reduced dietary protein on the ability of PP lymphocytes to differentiate into IgA-secreting plasma cells, weanling female BDF1 mice were fed on a 20% casein (20C) or a 4% casein (4C) diet for 5 to 6 weeks. Mice were then orally primed with sheep erythrocytes (SRBC) 4 times during a 2-week period to initiate differentiation of PP lymphocytes to anti-SRBC IgA production. Both the PP and splenic lymphocytes of primed mice were incubated with SRBC in vitro to evaluate the capacity to differentiate terminally to anti-SRBC IgA- and IgM-secreting plasma cells on antigenic stimulation. The in vitro IgA and IgM anti-SRBC immune response of PP lymphocytes from mice fed on 4C was significantly lower than the immune response of PP from 20C-fed mice. In contrast, splenic IgM and IgA in vitro immune responses to SRBC of orally primed 4C-fed mice were higher than the response of 20C-fed mice. Addition of Lyt1+ T lymphocytes from SRBC-primed donor mice or Interleukin 2 to the in vitro PP lymphocyte cultures partly restored the anti-SRBC IgA and IgM immune responses of mice fed on 4C.
KW - IMMUNE RESPONSE
KW - Protein deficiencies
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immunity reactions
KW - immunological reactions
KW - protein malnutrition
KW - Animal Models of Human Nutrition (VV140)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional applications of the Health and Nutrition Examination Surveys (HANES).
AU - Yetley, E.
AU - Johnson, C.
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
Y1 - 1987///
VL - 7
SP - 441
EP - 463
SN - 0199-9885
AD - Yetley, E.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19881402639. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Human Nutrition
N2 - The USA HANES data bases, along with their National Health Examination Surveys predecessors, provide a wealth of measures for assessing nutritional state and risk factors associated with chronic diseases. The breadth and nature of the measures obtained, the generalizability to US population groups, and the succession of and linkages among surveys over time are invaluable for development and evaluation of public health policy at the national level. As such, they make a significant contribution to the implementation of the National Nutrition Monitoring System. The various surveys in the HANES system are summarized and their characteristics are described. Discussion is focused on nutritional state assessments and results generated primarily for the purpose of assessing the prevalence of nutritional problems and nutritionally related risk factors for chronic diseases. Considerable attention is given to problem areas or potential problem areas. The complexities and cautions in using the surveys are identified and references for more detailed information are provided. The surveys are extremely powerful when used correctly and appropriately; however, their potential for misuse, intentionally or naively, is also great. Only by understanding the complexities and potential pitfalls can the use of results be enhanced in a scientific and responsible manner.
KW - estimation
KW - Health
KW - Nutritional state
KW - reviews
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional status
KW - status
KW - United States of America
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trace and ultra trace elements in nutrition: an overview. 1. Zinc, copper, chromium, vanadium and nickel.
AU - Fishbein, L.
JO - Toxicological and Environmental Chemistry
JF - Toxicological and Environmental Chemistry
Y1 - 1987///
VL - 14
IS - 1-2
SP - 73
EP - 99
SN - 0277-2248
AD - Fishbein, L.: Dep. Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19881403193. Publication Type: Journal Article. Language: English. Number of References: 144 ref. Subject Subsets: Human Nutrition
N2 - This review highlights the role in man and animals of the more important trace elements such as copper, zinc and chromium in terms of their essentiality, effects of their deficiency, their role in pregnancy cause and outcome, their biological availability and interactions as well as aspects of their recommended daily allowance. The potential role of a number of ultra trace elements in nutrition such as arsenic, nickel and vanadium are also considered.
KW - reviews
KW - Trace elements
KW - microelements
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of enzyme immunoassay and nucleic acid hybridization for detecting Sindbis virus in infected mosquitoes.
AU - Calisher, C. H.
AU - Auvinen, P.
AU - Mitchell, C. J.
AU - Rice, C. M.
AU - Hukkanen, V.
AU - Hyypiä, T.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 1987///
VL - 17
IS - 3-4
SP - 229
EP - 236
SN - 0166-0934
AD - Calisher, C. H.: Div. Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Dep. Health & Human Services, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19890595261. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
N2 - Males of Aedes aegypti were inoculated intrathoracically with prototype Sindbis virus, held at 26.7°C for 0-95 h and placed at -70°C. Individual mosquitoes were tested for virus by plaque assay in Vero cells, for viral RNA by nucleic acid hybridization using a cloned cDNA probe, and for viral protein by enzyme-linked immunosorbent assay (ELISA). Virus was detected by plaque assay as early as 8 h after infection. Sindbis virus RNA was detected by nucleic acid hybridization 18 h after infection and by ELISA 10 h after infection. The results of these comparisons suggested that both nucleic acid hybridization and ELISA are applicable to direct detection of Sindbis virus in mosquitoes containing virus at levels usually found during arbovirus epidemics.
KW - Arboviruses
KW - detection
KW - disease vectors
KW - ELISA
KW - Immunological techniques
KW - RNA
KW - Techniques
KW - vectors
KW - Aedes aegypti
KW - Culicidae
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Sindbis virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flaviviridae
KW - Alphavirus
KW - Togaviridae
KW - arthropod-borne viruses
KW - enzyme linked immunosorbent assay
KW - mosquitoes
KW - ribonucleic acid
KW - serological techniques
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of Uvitex 2B: a nonspecific fluorescent stain for detecting and identifying fungi and algae in tissue.
AU - Koch, H. H.
AU - Pimsler, M.
JO - Laboratory Medicine
JF - Laboratory Medicine
Y1 - 1987///
VL - 18
IS - 9
SP - 603
EP - 606
SN - 0007-5027
AD - Koch, H. H.: Division of Microbiology, Food and Drug Administration, Washington, DC 20306-6000, USA.
N1 - Accession Number: 19901206824. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A new product, Uvitex 2B, was examined for use as a nonspecific fluorescent stain for fungi and algae in tissue sections. Like Blankophor (BP) and Calcofluor (CF), this reagent binds chitin and cellulose in the cell walls of these organisms and fluoresces when exposed to UV light. BP and CF were both slightly insoluble at physiological pH (7.3) and solutions of these reagents became cloudy upon storage. Solubility was improved in weakly alkaline solutions (0.1M NaOH), but staining efficiency was reduced at higher pH. These reagents did not stain all organisms adequately and there was variable staining of some fungi. In contrast, Uvitex readily dissolved in phosphate-buffered saline (pH 7.3) and remained in solution for prolonged periods. All fungi and algae tested stained well with Uvitex, yielding an intense yellow-green fluorescence under fluorescein excitation conditions. Morphological features of fungi demonstrated by the Gomori's methenamine-silver stain were clearly seen in Uvitex-stained sections. It is concluded that the speed, sensitivity, reliability and ease of use suits Uvitex 2B for use in the frozen-section room, clinical laboratory or the physician's office.
KW - fluorescence
KW - staining
KW - techniques
KW - Fungi
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206824&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An international collaborative study on standardization of apolipoproteins A-I and B. 1. Evaluation of a lyophilized candidate reference and calibration material.
AU - Smith, S. J.
AU - Cooper, G. R.
AU - Henderson, L. O.
AU - Hannon, W. H.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1987///
VL - 33
IS - 12
SP - 2240
EP - 2249
SN - 0009-9147
AD - Smith, S. J.: Division of Environmental Health Lab. Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19881405750. Publication Type: Journal Article; Standard; Journal article. Corporate Author: International Union of Immunological Societies, Apolipoprotein Standardization Collaborating Group Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
KW - apolipoproteins
KW - blood
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881405750&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An international collaborative study on standardization of apolipoproteins A-I and B. 2. Evaluation of contributions of antisera to among-laboratory variance components.
AU - Henderson, L. O.
AU - Hannon, W. H.
AU - Smith, S. J.
AU - Cooper, G. R.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1987///
VL - 33
IS - 12
SP - 2250
EP - 2256
SN - 0009-9147
AD - Henderson, L. O.: Division of Environmental Health Lab. Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19881405753. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
KW - apolipoproteins
KW - blood
KW - estimation
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881405753&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining protein quality of infant formulas using in vivo and in vitro methods.
AU - Wood, B. A.
AU - Phillips, R. D.
AU - Eitenmiller, R. R.
AU - Soliman, A. M.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1987///
VL - 35
IS - 6
SP - 1195
EP - 1204
AD - Wood, B. A.: Atlanta Center for Nutrient Analysis, U.S. Food and Drug Administration, Atlanta, GA 30309, USA.
N1 - Accession Number: 19881402790. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - Weaned male Sprague-Dawley rats were given diets containing graded amounts of protein. Protein efficiency ratio (PER), linear regression and saturation kinetic models were applied to the data. Amino acid profiles, protein digestibility, calculated PER and discriminant PER were estimated in vitro. Each of the methods had serious shortcomings as a predictor of protein quality in infant formulas.
KW - estimation
KW - Infant formulae
KW - protein quality
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - infant formula
KW - infant formulas
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Albendazole therapy in alveolar hydatid disease: a report of favorable results in two patients after short-term therapy.
AU - Wilson, J. F.
AU - Rausch, R. L.
AU - McMahon, B. J.
AU - Schantz, P. M.
AU - Trujillo, D. E.
AU - O'Gorman, M. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1987///
VL - 37
IS - 1
SP - 162
EP - 168
SN - 0002-9637
AD - Wilson, J. F.: Dep. Surgery & Med., Alaska Native Med. Cent., Alaska Area Native Health Service, Indian Health Service, PO Box 7-741, Anchorage, AK 99510, USA.
N1 - Accession Number: 19870845557. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 54965-21-8. Subject Subsets: Helminthology; Public Health
N2 - In Alaska, USA, 7 patients from regions endemic for Echinococcus multilocularis diagnosed as having alveolar hydatid disease by ELISA, CT and ultrasound findings and for whom surgical interventions were planned, were treated with albendazole at 400 mg twice daily (adult dose) for courses of 28 days with drug-free intervals of 14 days. They were monitored for serum levels of albendazole and by complete blood counts and liver function tests. Viability of the metacestodes was tested by ip inoculation of infective material into Clethrionomys rutilus. Subsequently 5 patients were proved to have inactive lesions in which the parasite had died. In the 2 cases with active alveolar hydatids, albendazole therapy for 58 and 84 days respectively was beneficial, with normalization of serology, no evidence of recurrences (as judged by CT and/or ultrasound) and death of the parasite (judged on bio-assays). The cyst was resected in one patient but resection was not possible in the 2nd case, and the patient was given 10 additional courses of albendazole. Albendazole was hepatotoxic but resulting transaminase abnormalities were reversible. Close monitoring of liver function and haematology during treatment are essential.<new para>ADDITIONAL ABSTRACT:<new para>This clinical report principally concerns 2 asymptomatic Inuit with alveolar hydatid disease treated with albendazole (400 mg twice a day) for 2-3 months before operation. At operation, material was resected from both patients and this was sterile by inoculation. Reversible hepatocellular toxicity of some degree was seen in 6 of 7 patients treated.[Although this report is most encouraging, the viability of the lesions was not established before therapy.]D.L. Morris
KW - albendazole
KW - Anthelmintics
KW - cestode infections
KW - DRUG THERAPY
KW - helminths
KW - infections
KW - medical treatment
KW - metacestodes
KW - parasites
KW - treatment
KW - Alaska
KW - North America
KW - USA
KW - Cestoda
KW - Echinococcus
KW - Echinococcus multilocularis
KW - man
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - Cyclophyllidea
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Volatile halocarbon compounds in process water and processed foods.
AU - Uhler, A. D.
AU - Diachenko, G. W.
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
Y1 - 1987///
VL - 39
IS - 4
SP - 601
EP - 607
SN - 0007-4861
AD - Uhler, A. D.: Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19881408905. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - To determine if contamination of food by volatile hydrocarbon compounds (VHC) through contact with contaminated process water was widespread, process water and foods were collected from 15 food-processing plants in 9 different states of the USA and 39 food products were analysed. Chloroform, 1,1,1-trichloroethane, trichloroethylene, bromodichloromethane and perchloroethylene were all detected in process waters. All were at very low concentrations, apart from 2 samples from Florida which contained chloroform 60 and bromodichloromethane 14 mg/kg. However these were still below the Environmental Protection Agency's maximum contamination level of 100 mg/kg. In almost all cases VHC detected in process water did not appear in the finished food product at above 1 mg/kg. In the few positive findings, the amount was small, between 1 and 30 mg/kg. 1,1,1-Trichloroethane was detected in several food commodities, yet none was found in the process water. This suggests an alternative means of contamination.
KW - Foods
KW - hydrocarbons
KW - processing
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Body weight and cancer.
AU - Wolff, G. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987///
VL - 45
SP - 168
EP - 180
SN - 0002-9165
AD - Wolff, G. L.: Division of Comparative Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19871495543. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - Obesity per se seems to be associated with more rapid tumour formation. The prevalence of tumours seems to depend on interaction of diet- and body weight-related variables early in postnatal development and not on obesity itself. Environmental conditions in the maternal reproductive tract seem to affect the embryonic differentiation of those metabolic patterns and physiological characteristics of the foetus which determine how susceptible it will be, as an adult, to becoming obese and to developing cancer. A versatile genetically defined animal model system for elucidation of the physiological and molecular processes and mechanisms underlying the modulation of adult tumour risk by prenatal and postnatal diet- and growth-related factors is available for future studies.
KW - body weight
KW - Carcinoma
KW - Obesity
KW - risk
KW - fatness
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871495543&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differences in the pattern of weight growth of nutritionally at-risk and well-nourished infants.
AU - Kim, I.
AU - Pollitt, E.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987///
VL - 46
IS - 1
SP - 31
EP - 35
SN - 0002-9165
AD - Kim, I.: Food and Drug Administration, (HFF 265), Clinical Nutrition Branch, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19871400988. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - A mathematical model was used to examine the patterns of weight growth of 2 groups of infants exposed to various ecological and nutritional conditions and practices in Suilin, Taiwan, and Berkeley, California, USA. Statistical comparison of the indices of weight model estimated from longitudinal data demonstrated different value and profile contour of weight growth in those 2 populations. In addition to differences in the growth values, the growth patterns of those 2 groups are significantly different. Taiwanese infants experienced more pronounced upward and downward changes in growth velocity than did USA infants in the first 6 months of life. In the second 6 months, the USA infants showed a decline in growth velocity whereas the Taiwanese infants maintained a low and constant growth rate. Possible explanations for the different growth profile of the Taiwanese infants in the first 6 months may be related to catch-up growth after possible intrauterine undernutrition, genetic growth pattern of Taiwanese infants and growth characteristics of breast-fed infants.
KW - growth rate
KW - Infants
KW - nutritional state
KW - California
KW - Taiwan
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South East Asia
KW - Asia
KW - Formosa
KW - nutritional status
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871400988&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary copper deficiency and autoimmunity in the NZB mouse.
AU - Mulhern, S. A.
AU - Raveche, E. S.
AU - Smith, H. R.
AU - Lal, R. B.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987///
VL - 46
IS - 6
SP - 1035
EP - 1039
SN - 0002-9165
AD - Mulhern, S. A.: Division of Nutrition, HFF-265, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19881406459. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 7440-50-8. Subject Subsets: Human Nutrition
N2 - NZB mice were exposed from birth to a diet adequate or deficient in copper. By 6 weeks old the mice exposed to the Cu-deficient diet showed signs characteristic of Cu deficiency (anaemia, hypoceruloplasminaemia and achromatrichia). The splenic lymphocytes from the Cu-deficient group had reduced numbers of cells expressing the surface markers Ly-5, Ly-1, B-220 and sIg. Less than 10% of the splenic lymphocytes in this group were cycling, as estimated by flow cytometry analysis. The spontaneous 96-h anti-ss-DNA values in the Cu-deficient group were lower than those in the control group. The exogenous colony-forming units (CFU) were significantly increased in the Cu-deficient mice. The decreased splenic lymphoid population, decreased anti-ss-DNA titres and increased exogenous CFU in the Cu-deficient mice seem to be the result of an increase in erythropoiesis at the expense of lymphopoiesis.
KW - Copper
KW - deficiency
KW - immunity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Host Resistance and Immunity (HH600)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881406459&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of iodine in foods by cathodic stripping voltammetry.
AU - Holak, W.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1987///
VL - 59
IS - 17
SP - 2218
EP - 2221
AD - Holak, W.: Food and Drug Administration, Dep. Health and Human Services, New York Regional Lab., 850 Third Ave., Brooklyn, NY 11232-1593, USA.
N1 - Accession Number: 19871400917. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition
KW - estimation
KW - foods
KW - Iodine
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871400917&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ascaris lumbricoides suum: thermal death time of unembryonated eggs.
AU - Barnard, R. J.
AU - Bier, J. W.
AU - Jackson, G. J.
AU - McClure, F. D.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1987///
VL - 64
IS - 1
SP - 120
EP - 122
SN - 0014-4894
AD - Barnard, R. J.: Div. Microbiol., Cent. for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19880847762. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Helminthology; Public Health
N2 - A. suum eggs (20 000/ml chicken broth in sealed tubes) were incubated at 50, 52 or 55°C. Counts of dead eggs (those that did not embryonate upon subsequent incubation at room temperature for 21 days) were used in a probit analysis to estimate the lethal time (LT50-LT99) required at a constant temperature to kill a given percentage of eggs. The LT50s at 50, 52 and 55°C were 47.2, 18.4 and 1.6 min. Corresponding LT99s were 361.9, 41.9 and 4.8 min respectively.
KW - helminths
KW - ova
KW - parasites
KW - physiology
KW - survival
KW - temperature
KW - Ascaris
KW - Ascaris suum
KW - Nematoda
KW - Ascarididae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ascaris
KW - Ascaridida
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - thermal death
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19880847762&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of selected enzymes for thiamine determination.
AU - Defibaugh, P. W.
JO - Journal, Association of Official Analytical Chemists
JF - Journal, Association of Official Analytical Chemists
Y1 - 1987///
VL - 70
IS - 3
SP - 514
EP - 517
AD - Defibaugh, P. W.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19871401334. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 59-43-8. Subject Subsets: Human Nutrition
N2 - Takadiastase and α-amylase (Miles) were suitable enzymes for use in the AOAC method to estimate thiamin. Potato phosphatase was marginally suitable but wheat germ phosphatase, α-amylase (Sigma), Mylase 100 and Clarase were not acceptable.
KW - estimation
KW - Thiamin
KW - aneurin
KW - thiamine
KW - vitamin B1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871401334&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differential pulse polarographic determination of sulfites in foods: collaborative study.
AU - Holak, W.
AU - Patel, B.
JO - Journal, Association of Official Analytical Chemists
JF - Journal, Association of Official Analytical Chemists
Y1 - 1987///
VL - 70
IS - 3
SP - 572
EP - 578
AD - Holak, W.: Food and Drug Administration, New York Regional Lab., 850 Third Ave., Brooklyn, NY 11232-1593, USA.
N1 - Accession Number: 19871401343. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - foods
KW - SULFITES
KW - sulphites
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871401343&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid determination of methyl mercury in fish and shellfish: collaborative study.
AU - Hight, S. C.
JO - Journal, Association of Official Analytical Chemists
JF - Journal, Association of Official Analytical Chemists
Y1 - 1987///
VL - 70
IS - 4
SP - 667
EP - 672
AD - Hight, S. C.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19881404303. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 593-74-8. Subject Subsets: Human Nutrition
KW - estimation
KW - methylmercury
KW - Shellfish
KW - Fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881404303&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - History of the Food and Drug Administration's Total Diet Study - 1961 to 1987.
AU - Pennington, J. A. T.
AU - Gunderson, E. L.
JO - Journal, Association of Official Analytical Chemists
JF - Journal, Association of Official Analytical Chemists
Y1 - 1987///
VL - 70
IS - 5
SP - 772
EP - 782
AD - Pennington, J. A. T.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19881405581. Publication Type: Journal Article. Language: English. Number of References: 162 ref. Subject Subsets: Human Nutrition
N2 - The Total Diet Study provides the USA Food and Drug Admimistration with baseline information on the contents of pesticide residues, contaminants and nutrients in the food supply and in the diets of specific age-sex groups. The study also identifies trends and changes in the contents of those substances in the food supply and in diets over time and thereby assists in identifying potential public health problems. The evolution of the Total Diet Study from 1961 to 1987 is described. Food collections, sites of analysis, diets, food commodity groups, analytes, analytical methods, data transfer, publication of results, notable results, resources and advantages of the study are discussed.
KW - Diet studies
KW - history
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881405581&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Patterns of nutrient intake among dietary supplement users: attitudinal and behavioral correlates.
AU - Levy, A. S.
AU - Schucker, R. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1987///
VL - 87
IS - 6
SP - 754
EP - 760
SN - 0002-8223
AD - Levy, A. S.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19871499275. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - A national telephone interview survey of an age-stratified random sample of 2991 adults, age 16 years and over, provided detailed information from 1142 vitamin and mineral supplement users about their nutrient intake patterns from dietary supplements. Dietary supplement users were divided into 4 groups (light, moderate, heavy and very heavy) on the basis of the type and amount of nutrient intake from supplements. The light, moderate, heavy and very heavy nutrient intake groups accounted for 42, 16, 28 and 14%, respectively, of the total users. Young supplement users (16 to 25 years old) tended to be in the light user group. Older adults (41 to 64 years old) and residents of the western USA tended to be in the heavy and very heavy user groups. Users in the light and moderate nutrient intake groups generally used only one broad-spectrum vitamin and mineral product. Users in the heavy and very heavy groups were typically taking 2 or more specialized vitamin and mineral products at a time as part of a personalized supplement regimen. Heavy and very heavy nutrient intakes were associated with more frequent visits to health food stores, greater nutrition activity and less physician involvement. Light and moderate nutrient intakes were more likely to be associated with a defensive interest in avoiding nutritional deficiencies. The implications of generally different motivations for dietary supplement use are discussed in the context of public information strategies.
KW - Adults
KW - intake
KW - mineral supplements
KW - nutrients
KW - vitamin supplements
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871499275&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health objectives for the nation: moving toward the 1990s.
AU - Sorenson, A. W.
AU - Kavet, J.
AU - Stephenson, M. G.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1987///
VL - 87
IS - 7
SP - 920
EP - 925
SN - 0002-8223
AD - Sorenson, A. W.: Office of Disease Prevention and Health Promotion, Dep. Health and Human Services, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19871499499. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - The 1990 Objectives are an outgrowth of the 1979 USA Surgeon General's Report, Healthy People, which identified a set of 5 broad goals for improving the health of the American public through the decade of the 1980s. A year later, more than 500 health experts from the government and the private sector met to develop specific quantifiable objectives for each of the areas outlined in Healthy People. Fifteen topics, including improved nutrition, were used to formulate a framework for 227 objectives that give directions for a national programme of health promotion and disease prevention. In 1980, the Public Health Service published the report Promoting Health/Preventing Disease: Objectives for the Nation. A mid-course review of the 1990 objectives has been made and the results were published in 1986. In the nutrition area, it is apparent that some overall progress has been made, but data are insufficient to assess progress on several objectives, and others are unlikely to be achieved by 1990. Ultimately, however, the success of the objectives depends on the recognition that they are national, not federal, goals that require commitment to their implementation by both the public and the private sector.
KW - Health
KW - nutrition
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871499499&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mineral content of market samples of fluid whole milk.
AU - Pennington, J. A. T.
AU - Wilson, D. B.
AU - Young, B. E.
AU - Johnson, R. D.
AU - Vanderveen, J. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1987///
VL - 87
IS - 8
SP - 1036
EP - 1042
SN - 0002-8223
AD - Pennington, J. A. T.: Food and Drug Administration, U.S. Dep. Health and Human Services, Washington, DC, USA.
N1 - Accession Number: 19871400664. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Results from the USA Food and Drug Administration Total Diet Study on the nutrient element content of fluid whole cow's milk are presented and compared with previously published values. Whole milk was collected and analysed yearly from 1975 to 1985. Yearly and overall means were similar for all elements except iron and iodine. The Fe content of milk was generally low, but several samples had high values. The distribution of I in whole milk was wide (0.002 to 0.094 mg/100 g). The I content of milk is affected by the amount of I added to cattle feed and by the use of iodophor sanitizing solutions used by the dairy industry. Overall mean values of the elements in mg/100 g whole milk were: sodium 42, potassium 134, calcium 106, phosphorus 83, magnesium 9.8, Fe 0.07, zinc 0.37, copper 0.009, manganese 0.004, I 0.034 and selenium 0.001. Coefficients of variation were high (67 to 117%) for Fe, Cu, Mn, Se and I but ranged from 18 to 26% for the other elements. An 8-fl oz serving of whole milk is an excellent source of I, Ca, P and K. It also provides some Na, Mg, Zn and Se but is not a reliable source of Fe, Cu or Mn.
KW - Cows
KW - market milk
KW - Milk
KW - Milk composition
KW - minerals
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - milk constituents
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19871400664&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molybdenum, nickel, cobalt, vanadium, and strontium in total diets.
AU - Pennington, J. A. T.
AU - Jones, J. W.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1987///
VL - 87
IS - 12
SP - 1644
EP - 1650
SN - 0002-8223
AD - Pennington, J. A. T.: Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19881407002. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 7440-48-4, 7439-98-7, 7440-02-0, 7440-24-6, 7440-62-2. Subject Subsets: Human Nutrition
N2 - Molybdenum, nickel, cobalt, vanadium and strontium were estimated in 234 foods selected on the basis of results from the 1977-78 USA Department of Agriculture's Nationwide Food Consumption Survey and the Second National Health and Nutrition Examination Survey made by the National Center for Health Statistics between 1976 and 1980. Daily intakes of the elements were then estimated for 8 population groups arranged according to sex and age. Although intake values for Mo were below the estimated safe and adequate daily dietary intake established by the USA NRC for adolescents and adults and intake values of V were below those suggested by Nielsen [Bulletin of the New York Academy of Medicine (1984) 60, 177], there was no evidence that V deficiency existed in the population of the USA.
KW - Cobalt
KW - Diets
KW - Molybdenum
KW - Nickel
KW - Strontium
KW - trace elements
KW - Vanadium
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - microelements
KW - Mo
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881407002&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The 1990 National Nutrition Objectives: lessons for the future.
AU - Miller, S. A.
AU - Stephenson, M. G.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1987///
VL - 87
IS - 12
SP - 1665
EP - 1667
SN - 0002-8223
AD - Miller, S. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19881407013. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - The 1990 objectives are a first attempt to establish quantified goals in public health nutrition in the USA. Lessons from this experience can benefit future efforts. Apparent problems related, for example, to data, methodology, feasibility and clarity have hindered the implementation and monitoring of progress on several goals. A major step toward improvement is the development of standard criteria for evaluating proposed objectives. Dietitians and nutritionists have a special interest and responsibility in developing the National Nutrition Objectives for the year 2000. They also have special opportunities for integrating current and future nutrition objectives into programmes at the state and local levels.
KW - Nutrition programmes
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - nutrition programs
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881407013&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of lead in blood using electrothermal atomisation atomic absorption spectrometry with a L'vov platform and matrix modifier.
AU - Miller, D. T.
AU - Paschal, D. C.
AU - Gunter, E. W.
AU - Stroud, P. E.
AU - D'Angelo, J.
JO - Analyst
JF - Analyst
Y1 - 1987///
VL - 112
IS - 12
SP - 1701
EP - 1704
SN - 0003-2654
AD - Miller, D. T.: Nutritional Biochemisty Branch, Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19881405684. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
KW - blood
KW - estimation
KW - Lead
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881405684&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Digestion, absorption and effects on cholesterol absorption of menhaden oil, fish oil concentrate and corn oil by rats.
AU - Chen, I. S.
AU - Hotta, S. S.
AU - Ikeda, I.
AU - Cassidy, M. M.
AU - Sheppard, A. J.
AU - Vahouny, G. V.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1987///
VL - 117
IS - 10
SP - 1676
EP - 1680
SN - 0022-3166
AD - Chen, I. S.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19881405745. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Maize
N2 - Adult male rats were surgically provided with a drainage catheter in the left thoracic lymphatic channel and an indwelling duodenal catheter for constant infusion of physiological saline and 5% glucose. After overnight feed deprivation rats were given a single duodenal dose of an aqueous emulsion containing oleic acid, oil, menhaden oil or a fish oil concentrate (FOC) and [1,2-³H]cholesterol. Digestion and absorption were estimated by recovering the total fatty acids in the thoracic duct lymph during a 24-h collection period (after subtraction of the "baseline" endogenous fatty acids in the lymph). Cholesterol absorption in the thoracic duct lymph was significantly reduced with menhaden oil or FOC compared with that with maize oil. With various fat feedings, the major increases in lymph fatty acids were directly related to the dietary fatty acid content. The relative amounts of eicosapentaenoic acid (EPA) and arachidonic acid (AA) in the thoracic lymph were influenced by the lipid content of the emulsion. The EPA:AA ratio in control, oleic acid and maize oil was 0.12 to 0.25. When marine oil was given, the EPA:AA ratio was 0.78 to 0.98. The total amount of fatty acids in the lymph after marine oil was significantly less than that after maize oil. The results suggested that the digestion and absorption of menhaden oil and FOC were lower than those of maize oil. The EPA:AA ratio was increased in the thoracic lymph after feeding on dietary fish oil.
KW - absorption
KW - Cholesterol
KW - fish oils
KW - maize
KW - maize oil
KW - menhaden oil
KW - rats
KW - Zea mays
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - corn
KW - corn oil
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Occurrence of mycotoxins in food.
AU - Pohland, A. E.
AU - Wood, G. E.
A2 - Krogh, P.
T2 - Mycotoxins in food
JO - Mycotoxins in food
JF - Mycotoxins in food
Y1 - 1987///
SP - 35
EP - 64
CY - London; UK
PB - Academic Press Ltd.
SN - 0124266703
AD - Pohland, A. E.: Center for Food Safety and Applied Nutrition, Dep. Health and Human Services, Public Health Service, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19881407777. Publication Type: Miscellaneous. Language: English. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - It is apparent, in retrospect, that the considerable research efforts exerted in recent years on mycotoxins have: clearly identified a wide variety of mycotoxins as the causative agents in animal diseases/deaths; clearly established that human exposure to mycotoxins occurs frequently as a result of consumption of mould-damaged agricultural products or as a result of transmission from feeds to meat, milk and eggs; implicated mycotoxins in a wide variety of human maladies; and documented enormous economic losses worldwide as a result of the contamination of foods and feeds with moulds. These efforts have provided the basis for current attempts to control mycotoxins, and have also resulted in laws and regulations in many countries aimed at improving food quality. It is clear from the information generated to date that much needs to be done on developing information on which to base human exposure estimates. Much of the data generated in surveys, particularly the multimycotoxin surveys, are not amenable to evaluation because the authors of the reports do not accurately describe the sampling plans (if any) used, the characteristics of the methodology used (i.e., the recovery expected, coefficients of variation, method of confirmation of identity used, etc.), and do not indicate the existence of a quality control programme to allow interlaboratory comparison of findings. In spite of these facts, the progress of our knowledge about the involvement of mycotoxins in human health concerns is rapidly increasing.
KW - biodeterioration
KW - contamination
KW - foods
KW - Mycotoxins
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration (SS300)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881407777&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contemporary issues: diseases with a food vector.
AU - Archer, D. L.
AU - Young, F. E.
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
Y1 - 1988///
VL - 1
IS - 4
SP - 377
EP - 398
SN - 0893-8512
AD - Archer, D. L.: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Adminstration, Washington, DC 20204, USA.
N1 - Accession Number: 19911438206. Publication Type: Journal Article. Language: English. Number of References: 262 ref. Subject Subsets: Public Health; Human Nutrition
N2 - In this comprehensive review, the importance of foodborne disease, defined as encompassing a variety of clinical conditions the causes of which may be actively or passively transmitted by food, in relation to other prevalent diseases, is emphasized. The effect of foodborne pathogens on the microbiology of the gastrointestinal tract, and some theories concerning how new pathogens may arise are discussed. The occurrence and characteristics of particular acute gastroenteritis-causing agents are described in some detail, including those of Yersinia spp., Salmonella spp., Campylobacter spp., Aeromonas spp., Escherichia spp., Listeria monocytogenes, Vibrio spp., Bacillus cereus, Shigella spp. and other gram-negative bacteria. In addition, botulinal and staphylococcal food poisoning, protozoa and enterically transmitted viruses are considered. Acute respiratory and other non-gastrointestinal diseases have been attributed to enteric pathogens, both viruses and bacteria. It is now strongly indicated that foodborne pathogenic organisms may directly or indirectly cause or predispose human subjects to chronic diseases, e.g., acting as "environmental triggers" through a complete interaction with the host immune system. Such may include joint diseases, autoimmune thyroid disease, neural or neuromuscular disorders, nutritional disturbances, diseases of heart and vascular system and renal diseases. It is concluded that foodborne diseases are a major problem, in terms of both morbidity and mortality, and there is a need for integrated research between subdisciplines and expanded communication; however, with knowledge of their epidemiology they are for the most part preventable by improved hygienic practices and processing techniques.<new para>ADDITIONAL ABSTRACT:<new para>This review discusses the wide group of agents that cause acute gastroenteritis and other pathogens of concern as well as chronic diseases directly or indirectly caused by food-borne pathogens. The authors concluded that the emphasis on food microbiology and its status should be markedly increased in both universities and professional organizations.D.W. FitzSimons
KW - biodeterioration
KW - Food
KW - foodborne diseases
KW - pathogens
KW - Reviews
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911438206&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phosphine exposures in grain elevators during fumigation with aluminium phosphide.
AU - Zaebst, D. D.
AU - Blade, L. M.
AU - Burroughs, G. E.
AU - Morrelli-Schroth, P.
AU - Woodfin, W. J.
JO - Applied Industrial Hygiene
JF - Applied Industrial Hygiene
Y1 - 1988///
VL - 3
IS - 5
SP - 146
EP - 154
AD - Zaebst, D. D.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19902443337. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7803-51-2. Subject Subsets: Human Nutrition; Agricultural Engineering; Postharvest Research
N2 - Four surveys were conducted to assess worker exposure to phosphine during grain treatment with aluminium phosphide fumigants. Full-shift breathing zone sampling and area monitoring were conducted. Results indicated demonstrable, frequently excessive, exposures even under low air temp. (-8°C). Examination of the sampling data suggested that exposure was due to uncontrolled point sources and lack of local exhaust ventilation and depended on general level of fumigation activity. Recommendations are made for better ventilation, work practices and respiratory protection.
KW - air pollution
KW - Chemical treatment
KW - Ergonomics
KW - Fumigants
KW - Fumigation
KW - grain
KW - grain crops
KW - health hazards
KW - phosphine
KW - Pollution
KW - atmospheric pollution
KW - environmental pollution
KW - human engineering
KW - Crop Produce (QQ050)
KW - Pollution and Degradation (PP600)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Discovery of Aedes (Howardina) bahamensis in the United States.
AU - Pafume, B. A
AU - Campos, E. G.
AU - Francy, D. B.
AU - Peyton, E. L.
AU - Davis, A. N.
AU - Nelms, M.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1988///
VL - 4
IS - 3
SP - 380
EP - 380
SN - 8756-971X
AD - Pafume, B. A: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19890593426. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A. bahamensis was found in oviposition traps from Dade and Broward Counties, southern Florida, in October 1986. This represents the 1st time that this species and the subgenus Howardina have been recorded in the USA. Surveys suggest that the mosquito may be expanding its range.
KW - distribution
KW - Geographical distribution
KW - Florida
KW - North America
KW - USA
KW - Aedes
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Culicidae
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Aedes bahamensis
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus bahamensis
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Biological Resources (Animal) (PP710)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibody prevalence of St. Louis encephalitis virus in avian hosts in Los Angeles, California, 1986.
AU - McLean, R. G.
AU - Webb, J. P.
AU - Campos, E. G.
AU - Gruwell, J.
AU - Francy, D. B.
AU - Womeldorf, D.
AU - Myers, C. M.
AU - Work, T. H.
AU - Jozan, M.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1988///
VL - 4
IS - 4
SP - 524
EP - 528
SN - 8756-971X
AD - McLean, R. G.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19900594382. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - A study was conducted to determine the pattern of St. Louis encephalitis (SLE) virus activity in the avian populations of the Los Angeles metropolitan area in 1986. In total, 679 birds of 42 species were captured at 7 study sites. The overall prevalence of SLE neutralizing (N) antibody of 3% indicated enzootic transmission. Antibody prevalences were higher in birds sampled in the central part of the metropolitan area, which was consistent with other epidemiologic data. The use of specific avian species (e.g. house finches (Carpodacus mexicanus), house sparrows (Passer domesticus), mourning dove (Zenaida macroura), spotted dove (Streptopelia chinensis) and pigeons (Columba livia)) as sentinels for future surveillance of SLE virus activity was suggested.<new para>ADDITIONAL ABSTRACT:<new para>A study was conducted to determine the pattern of St Louis encephalitis (SLE) virus activity in the avian populations of the Los Angeles metropolitan area in 1986. In total, 679 birds of 42 species were captured at 7 study sites. The overall prevalence of SLE neutralizing (N) antibody of 3% indicated enzootic transmission. Antibody prevalences were higher in birds sampled in the central part of the metropolitan area, which was consistent with other epidemiologic data. The use of specific avian species as sentinels for future surveillance of SLE virus activity was suggested.AS
KW - antibodies
KW - Arboviruses
KW - DISEASE SURVEYS
KW - epidemiology
KW - Hosts
KW - infections
KW - introduced species
KW - Mosquito-borne diseases
KW - neutralization
KW - Sentinel animals
KW - St Louis encephalitis
KW - Urban areas
KW - viral diseases
KW - wild animals
KW - Wild birds
KW - California
KW - North America
KW - USA
KW - Birds
KW - Carpodacus
KW - Carpodacus mexicanus
KW - Columbidae
KW - Culicidae
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Fringillidae
KW - Passer domesticus
KW - Pigeons
KW - Ploceidae
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Streptopelia chinensis
KW - Zenaida
KW - Zenaida macroura
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Columbiformes
KW - birds
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flaviviridae
KW - Passeriformes
KW - Passer
KW - Ploceidae
KW - Columba
KW - Columbidae
KW - Flavivirus
KW - Fringillidae
KW - Carpodacus
KW - Streptopelia
KW - Zenaida
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - America (North)
KW - arthropod-borne viruses
KW - disease surveillance
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - viral infections
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of elevated temperatures to kill Aedes albopictus and Ae. aegypti.
AU - Smith, G. C.
AU - Eliason, D. A.
AU - Moore, C. G.
AU - Ihenacho, E. N.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1988///
VL - 4
IS - 4
SP - 557
EP - 558
SN - 8756-971X
AD - Smith, G. C.: Division of Vector-Borne Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900594392. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Exposure to a temperature of 46.1°C for 15 min was 100% lethal to all aquatic stages of A. albopictus and A. aegypti. The relatively modest temperatures needed to kill all stages of these mosquitoes offer a potential cost-effective means of disinsecting tyres without removal from shipping containers. The use of heat eliminates problems associated with fumigation because no dangerous toxicants are involved and no delay for gas dissipation is required once the treatment is completed.<new para>ADDITIONAL ABSTRACT:<new para>In test tubes dipped in a water bath exposure to 46.1 °C killed all eggs and larvae of Aedes aegypti and Ae. albopictus in 15 min, all pupae in 10 min and all adults in 30 min. Lethal times at 40.6, 43.3, 48.9 and 51.7 °C are also given, and heat treatment of shipping containers is advocated as an alternative to fumigation for preventing the further dispersal of these mosquitoes.J.E. Hudson
KW - control
KW - heat treatment
KW - insect control
KW - Quarantine
KW - Temperature
KW - Tyres
KW - Aedes
KW - Aedes aegypti
KW - Aedes albopictus
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Asian tiger mosquito
KW - disinsection
KW - heat processing
KW - high temperatures
KW - killing
KW - mosquitoes
KW - tires
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Aquatic Biology and Ecology (MM300)
KW - Other Control Measures (HH700)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aluminium content of foods and diets.
AU - Pennington, J. A. T.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1988///
VL - 5
IS - 2
SP - 161
EP - 232
SN - 0265-203X
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19881406094. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Registry Number: 7429-90-5. Subject Subsets: Human Nutrition
N2 - Literature data on the aluminium content of individual foods have been compiled, summarized and presented by food groups. The contribution of Al from food preparation and cooking utensils and from food additives is discussed. Literature data on the daily intake of Al are summarized, and the contribution of food groups to daily Al intake is estimated. The major sources of dietary Al include several with Al additives (grain products, processed cheese and salt) and several that are naturally high in Al (tea, herbs and spices). The Al that may migrate from Al utensils is probably not a major or consistent source of this element. Daily intakes of Al, as reported before 1980, were 18 to 36 mg daily. More recent data, which are probably more accurate, indicate daily intakes of 9 mg for teenage girls and women and 12 to 14 mg for teenage boys and men.
KW - Aluminium
KW - foods
KW - aluminum
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Residues of volatile halocarbons in margarines.
AU - Entz, R. C.
AU - Diachenko, G. W.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1988///
VL - 5
IS - 3
SP - 267
EP - 276
SN - 0265-203X
AD - Entz, R. C.: G.W. Diachenko (HFF-424), Division of Food Chemistry and Technology, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19881408663. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - Findings of residues of volatile halocarbons (VHC) such as 1,1,1-trichloroethane, trichloroethylene and tetrachloroethylene in margarine are reported. VHC were estimated by a headspace gas chromatographic method with electron capture detection. Identity was confirmed by headspace gas chromatography-mass spectrometry for some of the higher-level (100 to 5000 μg/kg) residues. A total of 70 stick, soft and diet soft margarines were purchased in the Washington, DC, metropolitan area. In addition, margarines and margarine ingredients were collected from 19 production lines. Those products plus the adhesives used in the packaging were examined. Concentrations of VHC ranging from 5 to 100 μg/kg were found in many of the margarines. The highest concentrations of any individual VHC (tetrachloroethylene 1 to 5 μg/kg) were found in margarines obtained from a supermarket located next to a dry cleaner. Possible sources of VHC residues are discussed.
KW - hydrocarbons
KW - Margarine
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The use of DNA colony hybridization for the identification of pathogenic microorganisms.
AU - Guilfoyle, D. E.
JO - American Biotechnology Laboratory
JF - American Biotechnology Laboratory
Y1 - 1988///
VL - 6
IS - 5
SP - 6
EP - 11
AD - Guilfoyle, D. E.: Food and Drug Administration, Department of Health and Human Services, New York Regional Laboratory, Brooklyn, New York, USA.
N1 - Accession Number: 19910880430. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Protozoology
N2 - Leishmania (using cloned kinetoplast DNA) is listed among the DNA probes in use or under development.
KW - diagnosis
KW - DNA probes
KW - human diseases
KW - parasites
KW - Leishmania
KW - man
KW - protozoa
KW - Sarcomastigophora
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910880430&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality among agricultural extension agents.
AU - Alavanja, M. C. R.
AU - Blair, A.
AU - Merkle, S.
AU - Teske, J.
AU - Eaton, B.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1988///
VL - 14
IS - 2
SP - 167
EP - 176
SN - 0271-3586
AD - Alavanja, M. C. R.: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health and Human Services, Executive Plaza North, Room 543, Bethesda, MD 20892, USA.
N1 - Accession Number: 19900501643. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - The death of agricultural extension agents employed by the Cooperative Extension Service (CES) of the US Department of Agriculture, who died between 1 January 1970 and 31 December 1979 (n = 1495 white males), was evaluated in proportionate-mortality and case-control studies. Proportionate-mortality analysis was used to identify cancers in this occupational group which could be compared with the US white male population as a whole. All cancers with a significantly elevated proportionate-mortality ratio were more thoroughly evaluated in the case-control study, where there is presumably less of a selection bias in the comparison. In the case-control study, cases of leukaemia were linearly correlated with duration of employment as an extension agent. Smaller, but non-significant, trends were seen for non-Hodgkin's lymphoma, multiple myeloma and brain cancer. The odds ratio for Hodgkin's disease and cancers of the colon, prostate and kidney did not vary with the number of years employed. The cancer distribution patterns resembled those seen among farmers, suggesting that agricultural factors may also play a role in the origin of cancerous tumours among extension agents.
KW - agricultural entomology
KW - Agriculture
KW - Death
KW - Disease surveys
KW - effects
KW - Epidemiology
KW - extension agents
KW - Farm workers
KW - Health
KW - Leukaemia
KW - mortality
KW - Neoplasms
KW - Nontarget effects
KW - Occupational hazards
KW - pesticides
KW - North America
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - blood cancer
KW - cancers
KW - death rate
KW - disease surveillance
KW - leucaemia
KW - leukemia
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Pesticides and Drugs (General) (HH400)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900501643&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional factors that may influence bioavailability of cadmium.
AU - Fox, M. R. S.
JO - Journal of Environmental Quality
JF - Journal of Environmental Quality
Y1 - 1988///
VL - 17
IS - 2
SP - 175
EP - 180
SN - 0047-2425
AD - Fox, M. R. S.: Nutrition Interaction Section, Division of Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19901452319. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
N2 - Cadmium accumulates slowly in the human body and a critically high level in the kidney can cause damage to the proximal renal tubule. Loss of calcium in the urine then contributes to extensive skeletal mineral loss. The bioavailability of Cd to animals and man can be markedly affected by nutritional state and dietary intakes of essential and other nutrients. In general, deficiencies and excesses of interacting nutrients exacerbate and protect, respectively, against the adverse effect of Cd. These effects on bioavailability occur primarily via changes in intestinal absorption, although accelerated uptake by the kidney sometimes occurs. The chemical form of Cd that is consumed experimentally can also modify response. Many aspects of the relations between Cd and nutrients are incompletely understood. From studies of population groups with high Cd intakes from certain foods, it seems that consumption of an adequate diet protects markedly against the adverse effects of Cd.
KW - availability
KW - Cadmium
KW - nutrition
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452319&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In-store nutrition information programs.
AU - Pennington, J. A.
AU - Wisniowski, L. A.
AU - Logan, G. B.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1988///
VL - 20
IS - 1
SP - 5
EP - 10
SN - 0022-3182
AD - Pennington, J. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19881408046. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The corporate headquarters of 83 grocery store chains in the USA were contacted to determine whether the chains used in-store nutrition information programmes. Of the chains 30 were using such programmes, which focused primarily on using shelf labels to identify foods that were low or lower in energy, sodium, fat, cholesterol or sugar, or that had favourable ratios of polyunsaturated to saturated fat. Most of the programmes used colour-coded shelf tags to identify the foods. The product labels and manufacturers' data were the primary sources of the nutrient information of the programmes. Although the programmes used similar techniques, nutrients selected for tagging and the terminology and criteria for tagging were different.
KW - consumers
KW - Nutrition education
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881408046&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Description of the holotypes of Aedes (Finlaya) purpureus and Ae. (Fin.) pecuniosus with a revalidation of the latter species (Diptera: Culicidae).
AU - Reinert, J. F.
JO - Mosquito Systematics
JF - Mosquito Systematics
Y1 - 1988///
VL - 20
IS - 1
SP - 55
EP - 68
SN - 0091-3669
AD - Reinert, J. F.: Med. Service Corps, Dep. of the Army, Office of The Surgeon General, ATTN: DASG-PSP, 5109 Leesburg Pike, Falls Church, VA 22041-3258, USA.
N1 - Accession Number: 19890593450. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Detailed descriptions of the adult female holotypes of A. purpureus and A. pecuniosus (from Australia) are provided. Illustrations of the female genitalia of the 2 holotypes are included. A. pecuniosus is resurrected from synonymy (with A. purpureus) and its distinguishing features are listed. A. priestleyi is included as a synonym of A. purpureus.
KW - holotypes
KW - nomenclature
KW - Synonymy
KW - taxonomy
KW - Types
KW - Australia
KW - Aedes
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Aedes pecuniosus
KW - Aedes priestleyi
KW - Aedes purpureus
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus pecuniosus
KW - Ochlerotatus purpureus
KW - redescription
KW - systematics
KW - valid species
KW - Taxonomy and Evolution (ZZ380)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890593450&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumer demand for detailed nutrition information: a case study.
AU - Levy, A. S.
AU - Schucker, R. E.
AU - Tenney, J. E.
AU - Mathews, O.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1988///
VL - 20
IS - 4
SP - 161
EP - 166
SN - 0022-3182
AD - Levy, A. S.: Division of Consumer Studies, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891410819. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - Sales of a nutrition information booklet were recorded in 25 Baltimore, Maryland, and 85 Washington, DC, supermarkets for 72 weeks. The Giant Food Inc. supermarket chain introduced the booklet entitled "Special Diet Alert Guide" in conjunction with the Special Diet Alert shelf label nutrition information programme. In Baltimore 9 to 10 and in Washington 7% of households that patronized Giant stores purchased a Special Diet Alert Guide at some point during this period. Much of the demand occurred in the first 12 weeks. Promotional advertising of the programme had a positive impact on booklet sales, but the effect was significantly larger in Baltimore stores. The generally higher level of interest in the guides observed among Baltimore shoppers compared with Washington shoppers is discussed in terms of the previous experience that Washington shoppers had with an earlier version of the guide.
KW - consumers
KW - Nutrition education
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891410819&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epizootic vesicular stomatitis in Colorado, 1982: isolation of virus from insects collected along the northern Colorado Rocky Mountain Front Range.
AU - Francy, D. B.
AU - Moore, C. G.
AU - Smith, G. C.
AU - Jakob, W. L.
AU - Taylor, S. A.
AU - Calisher, C. H.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1988///
VL - 25
IS - 5
SP - 343
EP - 347
SN - 0022-2585
AD - Francy, D. B.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900597596. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - Field studies were conducted during an epizootic of vesicular stomatitis virus (VSV) in Colorado to further assess the possible role of insects in the transmission of VSV. Insects associated with domestic livestock were collected at 11 premises along the Front Range of the Rocky Mountains during the 1982 epizootic of vesicular stomatitis. Insects were pooled by date, location, species and sex and were processed for virus isolation in 3 cell culture systems. 34 isolates of VSV, New Jersey serotype, were obtained from 51 036 insects. Of these, 27 isolates were from Musca domestica (126 pools/5285 specimens), 5 from other non-haematophagous Diptera (Chloropidae (Hippelates) and Anthomyiidae; 56 pools/936 specimens), and 2 from unengorged Simuliidae (predominantly Simulium vittatum and S. bivittatum; 55 pools/1221 specimens). Results suggest that nonblood-feeding insects, such as houseflies, play a role in VSV transmission and that blackflies also serve as vectors.
KW - Arboviruses
KW - disease vectors
KW - epidemiology
KW - vectors
KW - vesicular stomatitis viruses
KW - Colorado
KW - North America
KW - USA
KW - Anthomyiidae
KW - Chloropidae
KW - Diptera
KW - Hippelates
KW - insects
KW - Musca domestica
KW - Muscidae
KW - Rhabdoviridae
KW - Simuliidae
KW - Simulium bivittatum
KW - Simulium vittatum
KW - Vesiculovirus
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Chloropidae
KW - Musca
KW - Muscidae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Simulium
KW - Simuliidae
KW - Vesiculovirus
KW - Rhabdoviridae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - arthropod-borne viruses
KW - blackflies
KW - buffalo gnats
KW - house fly
KW - United States of America
KW - vesicular stomatitis virus
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597596&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological characterization of plaque-size variants of yellow fever virus in mosquitoes and mice.
AU - Miller, B. R.
AU - Adkins, D.
JO - Acta Virologica
JF - Acta Virologica
Y1 - 1988///
VL - 32
IS - 3
SP - 227
EP - 234
SN - 0001-723X
AD - Miller, B. R.: Div. Vector-Borne Viral Diseases, Cent. Infectious Diseases, Centers for Disease Control, Public Health Service, US Dep. Health & Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19880592908. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Plaque-size variants of a Peruvian strain of yellow fever virus were isolated, and their ability to infect orally and be transmitted by Aedes aegypti was compared with that of the uncloned parental virus. The same clonal isolates were analysed in mouse virulence experiments. No significant differences could be demonstrated in the capacities of the variants to infect and be transmitted by mosquitoes, nor were their differences in mouse virulence tests. The 17D vaccine virus (derived from the African Asibi strain) was, however, markedly attenuated in mosquitoes; also, a variant virus (Asibi strain) derived by continuous passage in HeLa cells (and attenuated for monkeys and mice) was markedly attenuated in mosquitoes when compared with its parent virus.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Infectivity
KW - Transmission
KW - vector competence
KW - vectors
KW - Peru
KW - South America
KW - Aedes aegypti
KW - Culicidae
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - yellow fever virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flaviviridae
KW - Flavivirus
KW - Andean Group
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - arthropod-borne viruses
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19880592908&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid-chromatographic determination of total hydroxyproline in urine.
AU - Dawson, C. D.
AU - Jewell, S.
AU - Driskell, W. J.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1988///
VL - 34
IS - 8
SP - 1572
EP - 1574
SN - 0009-9147
AD - Dawson, C. D.: Division of Environmental Health Lab. Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19891411706. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 51-35-4. Subject Subsets: Human Nutrition
N2 - In this method for quantifying 4-hydroxyproline in human urine, 50 μl urine is hydrolysed, derivatized with phenylisothiocyanate (PITC), and then quantified by reversed-phase high-performance liquid chromatography with ultraviolet detection. The detection limit in urine is 373 pg hydroxyproline per 50-μl injection. The total coefficients of variation for high- and low-concentration pools are 5.3% and 3.9%, respectively (10 runs in 10 days). The standard curve of the assay is linear over a range of 0 to 22 nmol per injection. The normal range for hydroxyproline excretion in men on an unrestricted diet was 123 to 308 μmol/24 h. Hydroxyproline concentrations are also reported in patients with metastatic bone disease and cirrhosis of the liver.
KW - estimation
KW - Hydroxyproline
KW - urine
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - oxyproline
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411706&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An evaluation of the trends in analytical performance of international apolipoprotein A-1 and B assays.
AU - Smith, S. J.
AU - Henderson, L. O.
AU - Cooper, G. R.
AU - Hannon, W. H.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1988///
VL - 34
IS - 8
SP - 1644
EP - 1646
SN - 0009-9147
AD - Smith, S. J.: Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19891411703. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition
N2 - Two international apolipoprotein (apo) A-I and B surveys were made in 1983 and 1986 with use of a freeze-dried serum measured by 55 and 91 participants, respectively. The chief source of variability in both surveys was among laboratories, but among-method variation was significant for apo B. Comparing the 1986 with the 1983 findings, there was a 60% decrease in apo A-I variability among laboratories, and a similar decrease (53%) was found for apo B. Evaluation of individual measurements suggests that some collaborators may have adjusted their calibrators toward the consensus values published in 1983.
KW - apolipoproteins
KW - blood
KW - estimation
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Standardization of lipid, lipoprotein, and apolipoprotein measurements.
AU - Cooper, G. R.
AU - Myers, G. L.
AU - Smith, S. J.
AU - Sampson, E. J.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1988///
VL - 34
IS - 8B
SP - B95
EP - B105
SN - 0009-9147
AD - Cooper, G. R.: Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19891411731. Publication Type: Journal Article. Language: English. Number of References: 91 ref. Subject Subsets: Human Nutrition
N2 - Accurate laboratory measurement of serum cholesterol has become a national public health priority. National proficiency testing surveys indicate that laboratory inaccuracy in cholesterol testing is more of a problem than precision. Like precision, accuracy is a function of multiple pre-analytical and analytical sources of variation. Controlling pre-analytical sources of variation helps minimize such sources of variation as intraperson biological, behavioural and clinical differences, and variations caused by sample collection, handling and shipping. Standardization of analytical sources of variation helps to achieve and maintain desirable analytical performance, accurate reporting and correct interpretation of a reported cholesterol result. The intraperson total variation in lipoproteins and their constituents is of primary interest when one is interpreting a single result or a series of results from a single person. The mean of multiple specimens from the same person is required if one is to obtain an accurate value for intraperson total cholesterol and minimize pre-analytical sources of variation. Standardizing analytical sources of variation in some instrument systems requires standardizing results by using "fresh" patients' specimens.
KW - apolipoproteins
KW - blood
KW - Blood lipids
KW - estimation
KW - Lipoproteins
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411731&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiple headspace extraction gas chromatography for the determination of volatile halocarbon compounds in butter.
AU - Uhler, A. D.
AU - Miller, L. J.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1988///
VL - 36
IS - 4
SP - 772
EP - 775
SN - 0021-8561
AD - Uhler, A. D.: Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891411143. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Multiple headspace extraction (MHE) gas chromatography (MHEGC) is a discontinuous gas extraction technique that provides straightforward, rapid quantitation of volatile compounds from a wide variety of matrices. The theory of MHE is summarized and an MHEGC procedure for the estimation of volatile halocarbons (VHC) in butter is described. Detection limits and quantitation limits, respectively, for 6 VHC in butter were (μg/kg): chloroform 2, 10; 1,1,1-trichloroethane 3, 10; carbon tetrachloride 1, 5; trichloroethylene 5, 15; bromodichloromethane 3, 12; tetrachloroethylene 2, 5. Over the concentration range 40 to 1500 μg/kg, average recovery (s.d.) for the 6 VHC was 95 ± 3.2%.
KW - Butter
KW - Cows
KW - determination
KW - estimation
KW - volatile compounds
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - volatile constituents
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biting activity of black flies in Guatemala: parity rates and differences between localities and habitats.
AU - Porter, C. H.
AU - Collins, R. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1988///
VL - 38
IS - 1
SP - 142
EP - 152
SN - 0002-9637
AD - Porter, C. H.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920510313. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Host-seeking activity of anthropophilic blackflies at 4 localities in Guatemala with different prevalence rates of onchocerciasis was assessed using human attractants and semimonthly catches over 1 year (1979-80). Density of host-seeking Simulium ochraceum was greatest at the locality with the highest incidence of onchocerciasis and very reduced at the 2 localities with low levels of human infection of Onchocerca volvulus. The overall percentage of parous host-seeking S. ochraceum at the 4 localities ranged from 41% to 49%. Host-seeking activity appeared to be concentrated near streams containing immature stages, and few females dispersed as far as 3 km away. S. metallicum was the second most frequently captured species; however, at the locality with the highest prevalence of onchocerciasis, its host-seeking density was much less than that of S. ochraceum. For S. metallicum, the overall percentage of parous females ranged from 28% to 34% at the 4 localities. S. metallicum were consistently taken in much greater numbers in coffee cultivation areas than in housing areas. Host-seeking S. callidum and S. gonzalezi also were captured.<new para>ADDITIONAL ABSTRACT:<new para>Using human bait, catches of Simulium were made twice a month from April 1979 to March 1980 in 4 localities on the slopes of the Atitlán volcano in south-west Guatemala at altitudes between 500 and 1580 m. The microfilaria infection rates of residents ranged between 90% and 14%. Catches of S. ochraceum were greatest at the locality with the highest incidence of onchocerciasis and very small at the 2 localities with low levels of human infection. S. metallicum was caught in lower numbers and it was estimated that 14% of these at 1 locality were actually S. horacioi. The zoophilic S. callidum was taken in relatively small numbers and S. gonzalezi occurred primarily in the 500 m locality.Multifactor analysis of variance (ANOVA) was used to investigate the relationship of season, habitat, site, and time of day to the host-seeking density of the 4 species. Breeding sites were defined and the percentage of parous females caught was estimated.James Haworth
KW - Behaviour
KW - Biting rates
KW - coffee
KW - Disease vectors
KW - habitats
KW - Host-seeking behaviour
KW - insect bites
KW - Parous rates
KW - plantations
KW - Central America
KW - Guatemala
KW - Coffea
KW - Diptera
KW - man
KW - Nematoda
KW - Onchocerca volvulus
KW - Onchocercidae
KW - Simuliidae
KW - Simulium
KW - Simulium callidum
KW - Simulium gonzalezi
KW - Simulium metallicum
KW - Simulium ochraceum
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Diptera
KW - Simuliidae
KW - Simulium
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - behavior
KW - blackflies
KW - buffalo gnats
KW - host-seeking behavior
KW - nematodes
KW - Secernentea
KW - Spirurida
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonality of adult black flies and Onchocerca volvulus transmission in Guatemala.
AU - Porter, C. H.
AU - Collins, R. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1988///
VL - 38
IS - 1
SP - 153
EP - 167
SN - 0002-9637
AD - Porter, C. H.: Med. Entomol. Res. Train. Unit./Guatemala, CDC, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19880848270. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Helminthology; Medical & Veterinary Entomology
N2 - The seasonal pattern of infective biting density of Simulium ochraceum (the main vector of O. volvulus in Guatemala) was studied for 14 months in 4 localities of the endemic region of Atitlán. Host seeking activity peaked in the early dry season (October-January) and declined rapidly to low in the late dry season (February-May). The frequency of O. volvulus larvae in the host-seeking flies also varied seasonally, and these variations were most marked for 3rd-stage larvae. At a hyperendemic locality (Finca Santa Isabel), 3rd-stage larvae were most frequent in February-March and least frequent in June-January. The frequency of early first-stage larvae exhibited the least seasonal variation, ranging from 0.0354 in August-September to 0.0628 in April-May. The transmission rate of O. volvulus by S. ochraceum also varied seasonally. At the same hyperendemic locality, infective biting density of S. ochraceum attained its greatest magnitude in February-March. The survival rate of female S. ochraceum attained its greatest magnitude in February-March. The survival rate of female S. ochraceum from one gonotrophic cycle to the next was estimated from the ratio of flies with early first-stage larvae to those with infective-stage larvae. These rates varied seasonally and ranged from 0.2132 to 0.3974, with the highest rates occurring in the late dry season.
KW - Behaviour
KW - Biting rates
KW - disease transmission
KW - disease vectors
KW - ecology
KW - epidemiology
KW - helminths
KW - parasites
KW - Seasonal abundance
KW - seasonal variation
KW - Survival
KW - transmission
KW - vectors
KW - Central America
KW - Guatemala
KW - Diptera
KW - Insects
KW - Invertebrates
KW - man
KW - Nematoda
KW - Onchocerca volvulus
KW - Simuliidae
KW - Simulium ochraceum
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Diptera
KW - Simulium
KW - Simuliidae
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - behavior
KW - blackflies
KW - buffalo gnats
KW - nematodes
KW - parasitic worms
KW - seasonal changes
KW - seasonal fluctuations
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19880848270&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolism of low density lipoprotein after storage.
AU - Leren, T. P.
AU - Blomhoff, R.
AU - Berg, K.
JO - Journal of the Oslo City Hospitals
JF - Journal of the Oslo City Hospitals
Y1 - 1988///
VL - 38
IS - 2
SP - 21
EP - 26
AD - Leren, T. P.: Dep. Medical Genetics, Public Health Service, Inst. Nutrition Research, Univ. Oslo, Oslo, Norway.
N1 - Accession Number: 19881407349. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition
N2 - Low-density lipoproteins (LDL) significantly change their properties during storage in sterile conditions at 4°C under air. As a consequence of those changes the plasma clearance of LDL is increased. Although the half-life of freshly isolated LDL was 5.7 h, the half-life of LDL stored for 1 week, 2 weeks or 5 months was 5.0 h, 4.25 h or 48 min, respectively. After intravenous injection of LDL that had been stored in the radiolabelled state, most of the radioactivity (58%) was recovered in the liver of which 59% was confined to the endothelial cells. When freshly isolated LDL was used, only 8% of the radioactivity was found in the liver of which 27% was in the endothelial cells. The data indicate a different metabolism of stored LDL compared with freshly isolated LDL.
KW - Low density lipoprotein
KW - storage
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881407349&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro cultivation of exoerythrocytic stages of the human malaria parasite Plasmodium malariae.
AU - Millet, P.
AU - Collins, W. E.
AU - Fisk, T. L.
AU - Nguyen-Dinh, P.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1988///
VL - 38
IS - 3
SP - 470
EP - 473
SN - 0002-9637
AD - Millet, P.: Malaria Branch, Div. Parasitic Dis. Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19880850844. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Exoerythrocytic stages of P. malariae (Uganda-I/CDC strain) were obtained in vitro by inoculating primary cultures of hepatocytes from a chimpanzee (Pan troglodytes) and a monkey (Aotus lemurinus griseimembra) with sporozoites from artificially infected Anopheles stephensi salivary glands. Schizonts were observed in chimpanzee hepatocytes 8, 11 and 13 days after inoculation. Only one schizont was seen in Aotus hepatocytes at day 13. The morphology and development rates of P. malariae exoerythrocytic stages obtained in vitro were similar to those previously described in vivo.<new para>ADDITIONAL ABSTRACT:<new para>Exoerythrocytic stage parasites of Plasmodium malariae were obtained in vitro by inoculating primary cultures of hepatocytes from a chimpanzee (Pan troglodytes) and a monkey (Aotus lemurinus griseimembra) with sporozoites. Schizonts were observed in chimpanzee hepatocytes 8, 11, and 13 days after inoculation. Only 1 schizont was seen in Aotus hepatocytes at day 13. The morphology and development rates of P. malariae exoerythrocytic stages obtained in vitro were similar to those previously described in vivo.AS
KW - culture techniques
KW - exoerythrocytic stages
KW - Human diseases
KW - parasites
KW - Apicomplexa
KW - Plasmodium malariae
KW - Primates
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - mammals
KW - vertebrates
KW - Chordata
KW - Haemosporida
KW - primary hepatocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19880850844&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Brus Laguna virus, a Gamboa bunyavirus from Aedeomyia squamipennis collected in Honduras.
AU - Calisher, C. H.
AU - Lazuick, J. S.
AU - Sudia, W. D.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1988///
VL - 39
IS - 4
SP - 406
EP - 408
SN - 0002-9637
AD - Calisher, C. H.: Div. Vector-Borne Viral Diseases, Cent. Infectious Diseases, Cent. Disease Control, Public Health Service, US Dep. Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19890593803. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A virus isolate from A. squamipennis collected in Honduras in 1967 was identified as a member of the Gamboa serogroup. This is the 9th Gamboa serogroup virus and the 8th shown to be a distinct serotype.
KW - Arboviruses
KW - disease vectors
KW - vectors
KW - Central America
KW - Honduras
KW - Aedeomyia squamipennis
KW - Bunyaviridae
KW - Culicidae
KW - Diptera
KW - Orthobunyavirus
KW - Aedeomyia
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Bunyaviridae
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - arthropod-borne viruses
KW - Brus Laguna virus
KW - Bunyavirus
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890593803&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The incidence of Listeria species in frozen seafood products.
AU - Weagant, S. D.
AU - Sado, P. N.
AU - Colburn, K. G.
AU - Torkelson, J. D.
AU - Stanley, F. A.
AU - Krane, M. H.
AU - Shields, S. C.
AU - Thayer, C. F.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1988///
VL - 51
IS - 8
SP - 655
EP - 657
SN - 0362-028X
AD - Weagant, S. D.: U.S. Food and Drug Administration, Federal Office Building, 901 1st Avenue, Seattle, WA 98174, USA.
N1 - Accession Number: 19901358384. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Samples of frozen seafood products from several countries were tested for the presence of L. monocytogenes and other Listeria spp. using the USA Food and Drug Administration (FDA) Listeria isolation method. Of 57 samples tested, 35 contained L. spp. and 15 of 57 samples contained L. monocytogenes. Samples found positive included raw shrimp, cooked and peeled shrimp, cooked crabmeat, raw lobster tails, langostinos, scallops, squid and surimi-based imitation seafoods. Positive samples were obtained from 9 different countries around the world.
KW - biodeterioration
KW - incidence
KW - pathogens
KW - Seafoods
KW - Listeria
KW - Listeria monocytogenes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901358384&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of inductively coupled plasma mass spectrometry for the determination of trace elements in foods.
AU - Satzger, R. D.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 1988///
VL - 60
IS - 22
SP - 2500
EP - 2504
AD - Satzger, R. D.: Elemental Analysis Research Center, Food and Drug Administration, 1141 Central Parkway, Cincinnati, OH 45202, USA.
N1 - Accession Number: 19891411955. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - Inductively coupled plasma mass spectrometry was used to estimate trace elements in foods. The effects of the major elements in foods (sodium magnesium, phosphorus, potassium, calcium) on the response of several trace elements in foods (aluminium, chromium, zinc, molybdenum, cadmium, lead) were evaluated. Enhancement or suppression of response is generally less than 10% in the presence of each major element added at 1000 mg/litre. The effects of mixed concomitants (Na, Mg, P, K, Ca) at concentrations of 0.1% and 0.2% total dissolved solids on Zn, Mo, Cd and Pb at 0.01 and 0.10 mg/litre were studied. The greatest suppression with the mixed concomitant solutions was on the response of Zn 0.01 mg/litre. Results are presented for dry ashed reference materials.
KW - estimation
KW - Foods
KW - trace elements
KW - microelements
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411955&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA Total Diet Study, April 1982-April 1984, dietary intakes of pesticides, selected elements, and other chemicals.
AU - Gunderson, E. L.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1988///
VL - 71
IS - 6
SP - 1200
EP - 1209
AD - Gunderson, E. L.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19911453742. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration (FDA) Total Diet Study, involved retail purchase of foods representative of the total diet of the population of the USA, preparation for table-ready consumption and individual analyses of 234 items from diets of 8 population groups. Dietary revision was based on 2 nationwide food consumption surveys. Data represented 8 food collections (market baskets) in regional metropolitan areas during the 2-year period. Dietary intakes of over 100 analytes are tabulated for the 8 population groups ranging from infants to elderly adults. Intakes of selected population groups were compared with representative previous findings. Of the 200 organic chemicals estimated BY The analytical methods used, an average of 64 pesticide and industrial chemical residues were found per market basket. The most frequent found organic residues were 1,1-dichloro-2,2-dichloro-phenylethylene and malathion used on fruits, vegetables and stored products such as grains. Values of most pesticide residues found were orders of magnitude lower than residue tolerances applicable to raw agricultural commodities established by Environmental Protection Agency. Dietary intakes were far below established Acceptable Daily Intakes (ADI). Intakes of persistent chlorinated pesticides have declined steadily since cessation of their agricultural uses over a decade ago. Even though the intakes of persistent chlorinated pesticides and polychlorinated biphenyls have declined in the last 20 years, their residues continue to occur at low values.
KW - contaminants
KW - Foods
KW - Pesticide residues
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453742&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Commercial blast-freezing of third-stage Anisakis simplex larvae encapsulated in salmon and rockfish.
AU - Deardorff, T. L.
AU - Throm, R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1988///
VL - 74
IS - 4
SP - 600
EP - 603
SN - 0022-3395
AD - Deardorff, T. L.: Fishery Research Branch, Food and Drug Administration, Box 158, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 19890858148. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Helminthology; Public Health
N2 - Sixty-four fish were blast-frozen to -35°C for 15 h to determine the effects of commercial blast-freezing on the viability of 3rd-stage larvae of A. simplex encapsulated in the muscle and viscera of sockeye salmon (Oncorhynchus nerka) and canary rockfish (Sebastes pinniger). Parallel tests were conducted on larval nematodes in 16 whole (round) salmon, 16 dressed salmon (heads and viscera removed), and 32 whole (round) rockfish. After blast-freezing, 4 in-the-round salmon, 4 dressed salmon, and 8 in-the-round rockfish were examined at 1, 24, 48, and 72 h. A total of 3539 dead and 6 live larvae were collected from the fish tissues after standard enzymatic digestion. Salmon were infected with 1245 of these larvae, and rockfish with 2300. The 6 live worms, 2 from salmon and 4 from rockfish rounds, were recovered from muscle 1 h after freezing; they were slightly motile and showed severe internal damage. No viable worms were found at or after 24 h. The commercial blast-freezing process effectively killed larval nematodes in whole or dressed fish. Market-ready samples of previously blast-frozen silver salmon (O. kisutch) and chum salmon (O. keta) fillets and chum salmon steaks yielded no live worms, thereby confirming the efficacy of this process.<new para>ADDITIONAL ABSTRACT:<new para>Salmon and rockfish have been implicated in the USA in the transmission of infective Anisakis larvae to man. Previous work with domestic freezers has shown that freezing of the intermediate fish host for specified lengths of time was effective in killing third-stage larvae of these parasites. Domestic freezers, however, do not simulate the methods generally used by the commercial fishing industry and the investigations reported in this paper were concerned with an evaluation of the effects of commercial blast freezing at -35 °C on the survival of Anisakis larvae.No viable worm was found at or after 24 h frozen storage. A freezing process was equally effective against whole or dressed fish. Blast freezing would thus seem an effective and simple method of eliminating a potential hazard to the fish-consuming public.T.J. Humphrey
KW - control
KW - fish
KW - Food
KW - Freezing
KW - helminths
KW - Human diseases
KW - larvae
KW - marine environment
KW - Marine fishes
KW - parasites
KW - Anisakis
KW - Anisakis simplex
KW - Fishes
KW - Nematoda
KW - Oncorhynchus nerka
KW - salmon
KW - Anisakidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anisakis
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Oncorhynchus
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - Sebastes
KW - Scorpaenidae
KW - Scorpaeniformes
KW - Ascaridida
KW - blast freezing
KW - elimination
KW - killing
KW - nematodes
KW - parasitic worms
KW - sea fishes
KW - Sebastes pinniger
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890858148&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of an inductively coupled plasma-atomic emission spectrometry method for the determination of calcium, magnesium, sodium, potassium, copper and zinc with atomic absorption spectroscopy and flame photometry methods.
AU - Dipietro, E. S.
AU - Bashor, M. M.
AU - Stroud, P. E.
AU - Smarr, B. J.
AU - Burgess, B. J.
AU - Turner, W. E.
AU - Neese, J. W.
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 1988///
VL - 74
SP - 249
EP - 262
SN - 0048-9697
AD - Dipietro, E. S.: Nutritional Biochemistry Branch, Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Public Health Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19901418842. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - Serum calcium, magnesium, copper and zinc concentrations obtained from the analysis of 77 serum samples by inductively coupled plasma-atomic emission spectrometry (ICP-AES) were compared with the results obtained using atomic absorption spectroscopy (AAS). Similarly, serum sodium and potassium values from the analysis of the same samples by ICP-AES were compared with values obtained by flame photometry. For each metal, the results from both methods were compared with a linear regression program that assumed error in both variables. The regression analysis showed that the ICP-AES method gave slightly higher Ca, Cu and Zn results and lower Mg results than the AAS methods, and lower Na and K results than the flame photometry method. Except for Na, the correlation between the results was very high, indicating that the ICP-AES results could be corrected to be equivalent to the atomic absorption or flame photometry results. The ICP-AES has the advantage of requiring less preparation and analysis time, and additional elements could be estimated simultaneously in the same sample.
KW - estimation
KW - Minerals
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418842&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA's Factored Food Vocabulary for food product description.
AU - McCann, A.
AU - Pennington, J. A. T.
AU - Smith, E. C.
AU - Holden, J. M.
AU - Soergel, D.
AU - Wiley, R. C.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1988///
VL - 88
IS - 3
SP - 336
EP - 341
SN - 0002-8223
AD - McCann, A.: Divisions of Information Resources Management and Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19901419809. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The USA Food and Drug Administration's Factored Food Vocabulary uses standardized language to describe characteristics of food products that are important for food safety and nutritional quality. Each food product is described by a set of descriptors from the following factors: product type; food source; part of plant or animal; physical state, shape or form; degree of preparation; cooking method; treatment applied; preservation method; packing medium; container or wrapping; food contact surface; and user group. The purpose of the vocabulary is to facilitate retrieval of food composition, food consumption, food contamination, and other food-related data relative to these factors. The major advantages of this system are flexibility with specificity, increased searchability with economy, and ease of change and updating.
KW - consumer protection
KW - descriptions
KW - Food products
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - consumer advocacy
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419809&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Associations between diet and health: the use of food consumption measurements, nutrient databases, and dietary guidelines.
AU - Pennington, J. A. T.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1988///
VL - 88
IS - 10
SP - 1221
EP - 1224
SN - 0002-8223
AD - Pennington, J. A. T.: Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911453547. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - The limitations, validity and reliability of methods of collecting food consumption data are discussed, followed by problems encountered when attempting to link foods consumed to those listed in a food composition database. The accuracy of information may also vary between databases depending on methods used to analyse foods. The difficulties in comparing actual intake with recommended daily allowances is also considered.
KW - Diet study techniques
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453547&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serving size issues in estimating dietary exposure to food substances.
AU - Lewis, C. J.
AU - Beloian, A. M.
AU - Yetley, E. A.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1988///
VL - 88
IS - 12
SP - 1545
EP - 1552
SN - 0002-8223
AD - Lewis, C. J.: Clinical Nutrition Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, US Public Health Service, Washington, DC 20204, USA.
N1 - Accession Number: 19911453562. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
N2 - The intake of cola beverages from 2 national surveys in the USA (NFCS 1977-78 and NHANES II) was used to examine assumptions important to a mathematical model employed to estimate dietary exposure to substances in food. The assumptions centre on the relation between frequency of consumption and serving size and on the constancy of serving size within age groups. Results showed the frequency of cola consumption was associated with 55 to 83% of the variability in cola intake and that mean cola serving size was not linearly related to frequency of consumption. However, while upper-level (90th + percentile) cola consumers consumed more frequently, they also had larger than average serving sizes. Therefore, because the model incorporates a standard serving size, it underestimated intake for the 2 groups of upper-level consumers examined. Furthermore, comparisons for cola serving sizes reported in the surveys showed differences by sex as well as systematic differences between the surveys in that the average difference between age and sex groups within each survey was similar, but NFCS 1977-78 had larger average size for each group than did NHANES II. Attention should be given to the nature of the food consumption databases used for estimating dietary exposure because systematic bias may cause considerable differences in estimation.
KW - Diet study techniques
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911453562&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Severe or marginal copper deficiency results in a graded reduction in immune status in mice.
AU - Mulhern, S. A.
AU - Koller, L. D.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1988///
VL - 118
IS - 8
SP - 1041
EP - 1047
SN - 0022-3166
AD - Mulhern, S. A.: Division of Nutrition, HFF-265, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19891412613. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 7440-50-8. Subject Subsets: Human Nutrition
N2 - From birth mice received diets containing copper 0.5, 1, 2 or 6 mg/kg. At 8 weeks old they were killed and Cu status and immune responsiveness were estimated. Only the groups given Cu 0.5 or 1 mg/kg showed signs of Cu deficiency, such as reduced serum ceruloplasmin, haemoglobin, haematocrit and red blood cell counts and characteristic changes in organ pathology. Body and lymphoid organ weights were altered in the groups given Cu 0.5 or 1 mg/kg. Males were more severely affected than females. A dose-related reduction in splenic T-cell subpopulations was noted with 0.5 and 1 mg/kg. Responses to lipopolysaccharide challenge were reduced, and an increase in spontaneous cycling cells was noted in the groups given 0.5 or 1 mg/kg. Only the group given 0.5 mg/kg had increased stem cell activity; this increase was probably due to increased erythropoiesis to meet increased demands for red blood cells in that group.
KW - Copper
KW - deficiency
KW - immunity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891412613&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stability of vitamin E in long-term stored serum.
AU - Gunter, E. W.
AU - Driskell, W. J.
AU - Yeager, P. R.
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 1988///
VL - 175
IS - 3
SP - 329
EP - 335
SN - 0009-8981
AD - Gunter, E. W.: Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19891411191. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 1406-18-4. Subject Subsets: Human Nutrition
KW - blood
KW - estimation
KW - Vitamin E
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411191&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alterations in colonic thymidine kinase enzyme activity induced by consumption of various dietary fibers.
AU - Calvert, R. J.
AU - Reicks, M.
JO - Proceedings of the Society for Experimental Biology and Medicine, USA
JF - Proceedings of the Society for Experimental Biology and Medicine, USA
Y1 - 1988///
VL - 189
IS - 1
SP - 45
EP - 51
AD - Calvert, R. J.: Experimental Nutrition Branch, US Food and Drug Administration, 200 "C" Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19891411817. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9002-06-6. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts
N2 - The relation between colonic thymidine kinase enzyme activity and mucin histochemistry and the reported effects of different dietary fibres on chemically induced colon carcinogenesis were studied. Diets containing fibres reported to inhibit (wheat bran) or enhance (guar gum, carrageenan) chemically induced colon carcinogenesis in rats were used. Male Fischer 344 rats were given a diet free from fibre or with 10% wheat bran, 5% guar gum or 5% carrageenan freely for 4 weeks. At the completion of the treatment period, the distal 12 cm of colonic mucosa was scraped off and homogenized for estimation of thymidine kinase activity and a 0.5-cm section of midcolon was processed by the high-iron diamine/Alcian blue method for mucin histochemistry. Final body weights did not differ significantly among groups. Thymidine kinase enzyme specific activity (μmol thymidine phosphate formed × 106/min mg protein, mean ± s.e.) was not different among the fibre-free, wheat bran and guar gum groups (10.98 ± 1.50, 7.41 ± 1.09 and 9.11 ± 2.04, respectively) but was increased (41.84 ± 4.65) in the carrageenan group. Mucin histochemistry showed no significant difference among dietary groups.
KW - colon
KW - Fibre
KW - sources
KW - thymidine kinase
KW - wheat
KW - Wheat bran
KW - rats
KW - Triticum
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - fiber
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411817&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of azo food dyes for mutagenicity and inhibition of mutagenicity by methods using Salmonella typhimurium.
AU - Prival, M. J.
AU - Davis, V. M.
AU - Peiperl, M. D.
AU - Bell, S. J.
JO - Mutation Research
JF - Mutation Research
Y1 - 1988///
VL - 206
IS - 2
SP - 247
EP - 259
AD - Prival, M. J.: Genetic Toxicology Branch (HFF-166), Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891410791. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Human Nutrition
N2 - The mutagenicity of 4 azo dyes (FD&C Yellow No. 5, FD&C Yellow No. 6, FD&C Red No. 40 and amaranth) that are used to colour food was evaluated. The methods used were: the standard Ames plate-incorporation assay; application of the standard plate assay to ether extracts of aqueous solutions of the dyes; a variant of the standard assay, using hamster liver S9, preincubation, FMN and other modifications designed to facilitate azo reduction; and reduction of the dyes with sodium dithionite, followed by ether extraction and the standard plate assay. Assays that include chemical reduction were included because azo compounds ingested orally are reduced in the intestine with the release of free aromatic amines. No mutagenic activity was seen for any of the azo dyes tested by using the standard Ames plate assay. Ether extracts of some samples of FD&C Yellow No. 6, FD&C Red No. 40 and amaranth were active, but only at high doses, generally 250 mgEq or more per plate. These results indicate the presence of low concentrations of ether-extractable mutagenic impurities. The FMN preincubation assay gave negative results for all dye samples tested. Most batches of FD&C Red No. 40 tested had mutagenic activity that was detectable when the ether extract of less than 1 mg dithionite-reduced dye was plated in the presence of S9. This implies that an impurity in these samples of FD&C Red No. 40 can be reduced to yield an ether-extractable mutagen. Dithionite-reduced samples of FD&C Yellow No. 6 and amaranth showed ether-extractable mutagenic activity only at much higher doses than those at which activity was seen with most dithionite-reduced samples of FD&C Red No. 40. FD&C Yellow No. 5 showed no mutagenic activity with this method. Mutagenic activity was not detected when FD&C Red No. 40 was tested by using the azo reduction preincubation assay with FMN. The failure to detect the activity of the mutagenic reduction product in the FMN azo reduction assay may be explained by the observation that addition of FD&C Red No. 40 interferes with the detection of the mutagenic activity of the extract of dithionite-reduced dye. In fact, all 4 azo food dyes inhibited the mutagenic activity of the FD&C Red No. 40 reduction product and N-(2-fluorenyl)acetamide.
KW - Azo compounds
KW - mutagens
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891410791&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - 1-(4-hydroxyphenyl)-, 1-(2,4-dihydroxyphenyl)- and 1-(2,5-dihydroxyphenyl)-2-bromoethanones: new labels for determination of carboxylic acids by high-performance liquid chromatography with electrochemical and ultraviolet detection.
AU - Munns, R. K.
AU - Roybal, J. E.
AU - Shimoda, W.
AU - Hurlbut, J. A.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1988///
VL - 442
SP - 209
EP - 218
SN - 0021-9673
AD - Munns, R. K.: Animal Drug Research Center, Food and Drug Administration, Denver Federal Center, Bldg. 20, Denver, CO 80225, USA.
N1 - Accession Number: 19881409768. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
KW - Carboxylic acids
KW - estimation
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881409768&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chromatography of proteins on hydrophobic interaction and ion-exchange chromatographic matrices mobile phase contributions to selectivity.
AU - Heinitz, M. L.
AU - Kennedy, L.
AU - Kopaciewicz, W.
AU - Regnier, F. E.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1988///
VL - 443
SP - 173
EP - 182
SN - 0021-9673
AD - Heinitz, M. L.: US Food and Drug Administration, 240 Hennepin Ave., Minneapolis, MN 55401-1999, USA.
N1 - Accession Number: 19881409278. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - The effect of mobile phase pH on the retention characteristics of 11 proteins was examined in hydrophobic interaction chromatography (HIC) on a SynChropak propyl stationary phase. Selectivity changed with eluent pH. The effect of the displacing salt on the separation of proteins on a weakly hydrophobic weak-anion-exchange chromatography (AEC) packing was examined. Some differences in selectivity were observed when sodium sulphate was used as the displacing salt, compared with that observed with sodium chloride in the eluent. These AEC packings exhibited electrostatic and hydrophobic properties, depending on the type and concentration of salt used in the mobile phase. The addition of 20% ethylene glycol to the mobile phase reduced the hydrophobic interactions. The application of weakly hydrophobic weak-cation-exchange packings to HIC of proteins was demonstrated. Elution of such columns with descending sodium sulphate gradients provided a selectivity different from that observed with a propyl stationary phase. Manipulation of mobile phases provided useful selectivity as a result of the combination of electrostatic and hydrophobic contributions to the separation process.
KW - estimation
KW - Proteins
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19881409278&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent developments in the microbiological analysis of foods.
AU - Andrews, W. H.
JO - Food Laboratory News
JF - Food Laboratory News
Y1 - 1988///
IS - 13
SP - 34
EP - 38
SN - 1100-3227
AD - Andrews, W. H.: US Food and Drug Administration, Division of Microbiology, 200 C Street S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19911430604. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Methods which have recently been approved by the Association of Official Analytical Chemists and have the greatest potential for widespread use in determining the presence of health-threatening toxins in foods, particularly Escherichia coli and Salmonella, are discussed.
KW - biodeterioration
KW - detection
KW - estimation
KW - Foods
KW - microorganisms
KW - Techniques
KW - Escherichia coli
KW - Man
KW - Salmonella
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - E. coli
KW - micro-organisms
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430604&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gene probes and their role in detecting foodborne bacterial pathogens.
AU - Hill, W. E.
JO - Food Laboratory News
JF - Food Laboratory News
Y1 - 1988///
IS - 13
SP - 38
EP - 44
SN - 1100-3227
AD - Hill, W. E.: Food and Drug Administration, Division of Microbiology, HFF-235, Washington, DC 20204, USA.
N1 - Accession Number: 19911430605. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - Methods for the characterization and enumeration of bacterial species in foods based on DNA hybridization are reviewed and discussed. Qualitative or quantitative data can be obtained as well as information about a strain's pathogenicity.
KW - estimation
KW - foods
KW - Bacteria
KW - Man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430605&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Nutrient interactions and the toxic elements aluminum, cadmium, and lead.
AU - Fox, M. R. S.
A2 - Bodwell, C.E.
A2 - Erdman, J.W., Jr.
T2 - Nutrient interactions.
JO - Nutrient interactions.
JF - Nutrient interactions.
Y1 - 1988///
SP - 313
EP - 349
CY - New York, NY; USA
PB - Marcel Dekker, Inc.
SN - 0824778685
AD - Fox, M. R. S.: Division of Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19891411269. Publication Type: Conference paper. Language: English. Number of References: 112 ref. Registry Number: 7429-90-5, 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition
N2 - High levels of toxic elements can interfere with the bioavailability of essential nutrients. Deficient intakes of certain essential nutrients can increase the adverse effects of the toxic elements due to fairly specific interactions, often in the intestinal lumen or at the site of intestinal absorption. Metabolic interactions also occur after absorption, which can markedly alter nutrient function as well as the adverse effects of the toxic element. Most experimental studies have addressed the effects of single nutrient-single toxic element interactions. This is, however, simpler than the real-life situation in man. Many studies designed to yield data applicable to man remain to be done. To avoid increased risk from toxic elements, consumption of an adequate and varied diet is essential. Many of the foods that supply significant amounts of a toxic element are also good sources of one or more nutrients that reduce the absorption/toxicity of the toxic element. Increased intakes above requirement of one or a limited number of nutrients to protect against toxic elements could result in imbalances among essential nutrients themselves and cause adverse health effects.
KW - aluminium
KW - cadmium
KW - food technology
KW - interactions
KW - lead
KW - Nutrients
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aluminum
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411269&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Interactions of food additives and nutrients.
AU - Vanderveen, J. E.
A2 - Bodwell, C.E.
A2 - Erdman, J.W., Jr.
T2 - Nutrient interactions.
JO - Nutrient interactions.
JF - Nutrient interactions.
Y1 - 1988///
SP - 351
EP - 363
CY - New York, NY; USA
PB - Marcel Dekker, Inc.
SN - 0824778685
AD - Vanderveen, J. E.: Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19891411270. Publication Type: Conference paper. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition
N2 - A general review is given of the types of interactions between food additives and nutrients that have been identified through scientific research. The criteria by which food additives are to be reviewed for approval are discussed.
KW - food additives
KW - food technology
KW - interactions
KW - Nutrients
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Additives (QQ130)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891411270&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The arboviruses: epidemiology and ecology. Volume I.
A2 - Monath, T. P.
T2 - The arboviruses: epidemiology and ecology. Volume I.
Y1 - 1988///
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849343852
AD - Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19900596878. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - This is the first of 5 volumes on the epidemiology of arthropod-borne viruses (belonging to the families Togaviridae, Flaviviridae, Bunyaviridae, Reoviridae and Rhabdoviridae). It contains 13 chapters of a general nature, including the impact of arboviruses on human and animal health, classification and geographic distribution, virus variation and evolution, vector-virus relationships, behavioural and ecological aspects of arthropod vectors affecting virus transmission, host ecology, and modelling of arbovirus infections.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Domestic animals
KW - epidemiology
KW - Mosquito-borne diseases
KW - Tickborne diseases
KW - Transmission
KW - Vector-borne diseases
KW - Vectors
KW - Viral diseases
KW - Bunyaviridae
KW - Flaviviridae
KW - Man
KW - Reoviridae
KW - Rhabdoviridae
KW - Togaviridae
KW - Viruses
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - positive-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dsRNA viruses
KW - Mononegavirales
KW - arthropod-borne viruses
KW - viral infections
KW - Animal Health and Hygiene (General) (LL800)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596878&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The arboviruses: epidemiology and ecology. Volume II.
A2 - Monath, T. P.
T2 - The arboviruses: epidemiology and ecology. Volume II.
Y1 - 1988///
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849343860
AD - Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19900596879. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - This book, the 2nd of 5 volumes on the epidemiology of arthropod-borne viruses, contains 10 chapters reviewing individual viruses or virus groups (arranged alphabetically by virus name). The reviews are of a uniform nature, in each of which the following subjects are discussed: historical background; virology; disease associations (in man, domestic animals and wildlife); epidemiology; transmission cycles (evidence from field and experimental infection studies, and maintenance/overwintering mechanisms); ecological dynamics; surveillance; investigation of epizootics; prevention and control; and future research. This volume covers African horse sickness to dengue.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Domestic animals
KW - epidemiology
KW - Mosquito-borne diseases
KW - Tickborne diseases
KW - Transmission
KW - Vector-borne diseases
KW - Vectors
KW - Viral diseases
KW - Bunyaviridae
KW - Flaviviridae
KW - Man
KW - Reoviridae
KW - Rhabdoviridae
KW - Togaviridae
KW - Viruses
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - positive-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dsRNA viruses
KW - Mononegavirales
KW - arthropod-borne viruses
KW - viral infections
KW - Animal Health and Hygiene (General) (LL800)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596879&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The arboviruses: epidemiology and ecology. Volume III.
A2 - Monath, T. P.
T2 - The arboviruses: epidemiology and ecology. Volume III.
Y1 - 1988///
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849343879
AD - Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19900596880. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - This is the 3rd of 5 volumes dealing with the epidemiology of arthropod-borne viruses. It contains 12 chapters which review viral diseases from eastern equine encephalomyelitis to o'nyong-nong virus disease. The treatment is similar to that of volumes II, IV and V.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Domestic animals
KW - epidemiology
KW - Mosquito-borne diseases
KW - Tickborne diseases
KW - Transmission
KW - Vector-borne diseases
KW - Vectors
KW - Viral diseases
KW - Bunyaviridae
KW - Flaviviridae
KW - Man
KW - Reoviridae
KW - Rhabdoviridae
KW - Togaviridae
KW - Viruses
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - positive-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dsRNA viruses
KW - Mononegavirales
KW - arthropod-borne viruses
KW - viral infections
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596880&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ca, P, Mg, Zn, Cu, Mn, Na, K, and Cl contents of infant formulas manufactured in the United States.
AU - Hamill, T. W.
AU - Young, E. R.
AU - Eitenmiller, R. R.
AU - Hogarty, C. D.
AU - Soliman, A. M.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1989///
VL - 2
IS - 2
SP - 132
EP - 139
SN - 0889-1575
AD - Hamill, T. W.: A.M. Soliman, Atlanta Center for Nutrient Analysis, Food and Drug Administration, 60 Eighth Street, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 19901419690. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition; Soyabeans; Dairy Science
N2 - A total of 135 infant formula samples from 4 USA manufacturers were assayed for elemental composition during 1981-85. Product types consisted of ready-to-feed (60), concentrates (47) and powders (28), prepared with milk-base (78) or soya-base (57). Mean elemental contents ± s.d. per 100 kcal were Ca 85 ± 18 mg, P 60 ± 11 mg, Mg 11 ± 3 mg, Zn 0.9 ± 0.3 mg, Cu 110 ± 32 μg, Mn 87 ± 89 μg, Na 38 ± 11 mg, K 120 ± 21 mg and Cl 66 ± 8 mg. Mean values for iron (77 samples) that were previously reported are updated to include data for 135 samples. Soya-based formulas had higher content of Ca, P, Mg, Cu, Mn, Na and K. Elemental contents of formulas produced by different firms were different. Mean content as a percentage of label declaration were 106 (Ca), 104 (P), 133 (Mg), 137 (Fe), 132 (Zn), 136 (Cu), 166 (Mn), 106 (Na), 116 (K) and 105 (Cl). The mean Ca:P ratios were 1.4 for milk-based and 1.5 for soya-based formulas. All products met requirements of the 1980 Infant Formula Act except for 2 samples that had Cu contents lower than Act specifications.
KW - composition
KW - Cows
KW - Infant foods
KW - infant formulae
KW - minerals
KW - Soyabean products
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - infant formula
KW - infant formulas
KW - soybean products
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
KW - Other Produce (QQ070)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419690&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin D3 and vitamin K1 levels in infant formula produced in the United States.
AU - Landen, W. O., Jr.
AU - Eitenmiller, R. R.
AU - Soliman, A. M.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1989///
VL - 2
IS - 2
SP - 140
EP - 148
SN - 0889-1575
AD - Landen, W. O., Jr.: A.M. Soliman, Atlanta Center for Nutrient Analysis, Food and Drug Administration, 60 Eighth Street NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 19901419691. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 67-97-0, 84-80-0. Subject Subsets: Human Nutrition; Soyabeans; Dairy Science
N2 - A total of 70 milk- and soya-based infant formulas from 4 USA manufacturers were assayed from October 1985 to September 1987 for cholecalciferol (CC) and phylloquinone (K1). Mean vitamin concentrations per 100 kcal were 71 IU for CC and 18 μg for K1. CC concentrations (IU/100 kcal) were similar in soya-based (72) and milk-based (70) formulas. K1 concentrations (μg/100 kcal) were higher in soya-based (22) than in milk-based (15) formulas. There were differences in CC and K1 concentrations in formulas produced by different manufacturers. Mean concentrations in the manufacturers' products ranged from 66 to 78 IU/100 kcal for CC and 15 to 24 μg/100 kcal for K1. In the samples concentrations of CC ranged from 41 to 99 IU/100 kcal and for K1 ranged from 8 to 39 μg/100 kcal. All formulas met minimum requirements of the 1980 Infant Formula Act for CC and K1. For CC, none of the formulas exceeded the maximum of 100 IU/100 kcal specified by the Act, and the mean content was 177% of the minimum requirement of 40 IU/100 kcal. On the basis of the Act requirement for K1 of 4 μg/100 kcal, milk-based and soya-based formulas contained 368 and 555%, respectively, of the minimum required content.
KW - cholecalciferol
KW - Cows
KW - Infant foods
KW - infant formulae
KW - phylloquinone
KW - Soyabean products
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - infant formula
KW - infant formulas
KW - phytonadione
KW - soybean products
KW - United States of America
KW - vitamin D3
KW - vitamin K1
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
KW - Other Produce (QQ070)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419691&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of efficacy of pyrimethamine prophylaxis in pregnant Nigerian women.
AU - Nahlen, B. L.
AU - Akintunde, A.
AU - Alakija, T.
AU - Nguyen-Dinh, P.
AU - Ogunbode, O.
AU - Edungbola, L. D.
AU - Adetoro, O.
AU - Breman, J. G.
JO - Lancet
JF - Lancet
Y1 - 1989///
VL - 2
IS - 8667
SP - 830
EP - 834
AD - Nahlen, B. L.: Malaria Branch, Div. Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19890859129. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 58-14-0. Subject Subsets: Protozoology
N2 - Of 900 pregnant women examined in Ilorin, Kwala State, Nigeria, 212 (24%) had malaria. 209 had single Plasmodium falciparum infections; the others had mixed infections. Infections were significantly more common in primigravidae than in multigravidae. 88 women who were less than 32 weeks pregnant and were infected only with P. falciparum were given 25 mg of pyrimethamine weekly for suppressive prophylaxis. Parasitaemia did not clear in 59 women, and 6 of 10 in vitro tests for pyrimethamine resistance were positive. P. falciparum infection in 71 pregnant women was cured with chloroquine at 25 mg/kg. Seven days later 34 women started causal prophylaxis with 25 mg pyrimethamine weekly. Recrudescence occurred in 8 women on prophylaxis and in 11 controls. It is concluded that pyrimethamine is not effective for suppressive or causal prophylaxis of P. falciparum in pregnant women in Ilorin.
KW - Antimalarials
KW - Antiprotozoal agents
KW - Drug resistance
KW - Females
KW - Human diseases
KW - parasites
KW - pregnancy
KW - prophylaxis
KW - Pyrimethamine
KW - Africa
KW - Nigeria
KW - Apicomplexa
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - gestation
KW - pyrimethamine resistance
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890859129&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance of St. Louis encephalitis virus vectors in Grand Junction, Colorado, in 1987.
AU - Tsai, T. F.
AU - Smith, G. C.
AU - Happ, C. M.
AU - Kirk, L. J.
AU - Jakob, W. L.
AU - Bolin, R. A.
AU - Francy, D. B.
AU - Lampert, K. J.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1989///
VL - 5
IS - 2
SP - 161
EP - 165
SN - 8756-971X
AD - Tsai, T. F.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900596395. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Grand Junction, Colorado, was the site of a St. Louis encephalitis (SLE) outbreak in 1985. Epidemiological and ecological investigations in 1985 and 1986 suggested that Culex tarsalis may not have been the exclusive vector in the outbreak and that C. pipiens may have contributed to transmission as an accessory vector. A limited field study in 1987 generally confirmed observations from 1986 that C. pipiens was more abundant than C. tarsalis in late summer when SLE virus transmission normally occurs. In both years, infection rates in C. tarsalis were higher than in C. pipiens, but in 1987 the only SLE virus isolate from C. pipiens was obtained early in the season. Truck trap collections showed that C. pipiens was the principal vector species collected, comprising 86% of the total. Light trap collections underestimated the population of C. pipiens; gravid trap collections gave a closer approximation of the relative proportions of C. pipiens and C. tarsalis in the vector mosquito population after midsummer.
KW - Arboviruses
KW - CDC light traps
KW - disease transmission
KW - disease vectors
KW - insect traps
KW - Mosquito-borne diseases
KW - oviposition traps
KW - Surveillance
KW - Transmission
KW - Traps
KW - vectors
KW - Colorado
KW - North America
KW - USA
KW - Culex
KW - Culex pipiens
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flaviviridae
KW - Flavivirus
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - arthropod-borne viruses
KW - CDC miniature light traps
KW - CDC traps
KW - mosquitoes
KW - ovitraps
KW - truck traps
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596395&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occurrence of Culex erythrothorax in southeastern Colorado and report of virus isolations from this and other mosquito species.
AU - Jakob, W. L.
AU - Davis, T.
AU - Francy, D. B.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1989///
VL - 5
IS - 4
SP - 534
EP - 536
SN - 8756-971X
AD - Jakob, W. L.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900597777. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Tropical Diseases
N2 - Significant numbers of C. erythrothorax were collected during arbovirus surveillance in 1987 and 1988 at Las Animas, Bent County, on the high plains of southeastern Colorado. This finding extends the range of this species to the eastern side of the Rocky Mountains. The isolation of western equine encephalitis virus in 1988 from both C. tarsalis and C. erythrothorax (as well as from Aedes vexans) suggests that C. erythrothorax also may be involved in the endemic cycle of this virus in the area. St. Louis encephalitis, Hart Park, Turlock and a Bunyamwera group virus (the latter from Anopheles quadrimaculatus) were also isolated from the mosquitoes collected.<new para>ADDITIONAL ABSTRACT:<new para>Significant numbers of Culex erythrothorax were collected during arbovirus surveillance in 1987 and 1988 at Las Animas, Bent County, on the high plains of southeastern Colorado. This finding extends the range of this species to the eastern side of the Rocky Mountains. The isolation of western equine encephalitis virus in 1988 from both Cx. tarsalis and Cx. erythrothorax suggests that the latter also may be involved in the endemic cycle of this virus in the area. St Louis encephalitis, Hart Park, Turlock, and a Bunyamwera group virus were also isolated from the mosquitoes collected.AS
KW - arboviruses
KW - disease vectors
KW - distribution
KW - Epidemiology
KW - Geographical distribution
KW - Mosquito-borne diseases
KW - vectors
KW - Colorado
KW - North America
KW - USA
KW - Aedes vexans
KW - Alphavirus
KW - Anopheles quadrimaculatus
KW - Bunyamwera virus
KW - Bunyaviridae
KW - Culex
KW - Culex erythrothorax
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Hart Park virus
KW - Orthobunyavirus
KW - Rhabdoviridae
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Togaviridae
KW - Turlock virus
KW - Western equine encephalitis virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Anopheles
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - Culex
KW - Flaviviridae
KW - Rhabdoviridae
KW - Mononegavirales
KW - Flavivirus
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - America (North)
KW - arthropod-borne viruses
KW - Bunyamwera serogroup viruses
KW - Bunyavirus
KW - mosquitoes
KW - United States of America
KW - Biological Resources (Animal) (PP710)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597777&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent studies on the effect of dehydroepiandrosterone on the metabolism of carcinogens in vivo.
AU - Prasanna, H. R.
AU - Hart, R. W.
AU - Magee, P. N.
JO - Journal of Toxicology, Toxin Reviews
JF - Journal of Toxicology, Toxin Reviews
Y1 - 1989///
VL - 8
IS - 1-2
SP - 121
EP - 131
SN - 0731-3837
AD - Prasanna, H. R.: Department of Health and Human Services/Public Health Service/Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19911208279. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 20 ref. Registry Number: 53-43-0. Subject Subsets: Medical & Veterinary Mycology
N2 - The influence of dehydroepiandrosterone [prasterone] (DHEA) on the metabolism and macromolecular interactions of the hepatocarcinogens NDMA, AFB1 and the mammary carcinogen DMBA were investigated to understand some of the mechanisms involved in the inhibition of initiation of tumours by DHEA; notably metabolic activation of the carcinogens and their adduct formation with hepatic DNA. Binding of these carcinogens to hepatic DNA was significantly inhibited in the steroid-fed rats. However, the binding of these carcinogens to total liver protein was 2-3 fold higher in the DHEA-fed rats. In vivo and in vitro metabolic studies indicated that DHEA enhanced the metabolic activation of these carcinogens in the liver. The implications of these results in the delineation of the molecular mechanisms involved in the anticarcinogenic action of DHEA are discussed.
KW - Aflatoxins
KW - diet
KW - Mycotoxins
KW - poisoning
KW - prasterone
KW - susceptibility
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Agricultural and biological aspects of aflatoxin related health hazards
KW - dehydroepiandrosterone
KW - fungal toxins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208279&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional assessment of twelve protein foods/ingredients.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1989///
VL - 9
IS - 1
SP - 83
EP - 92
SN - 0271-5317
AD - Jenkins, M. Y.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891412957. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Soyabeans; Wheat, Barley & Triticale Abstracts; Dairy Science
N2 - Male weanling Sprague-Dawley rats were given diets containing 10% protein by weight of each of 12 protein foods or ingredients for 4 weeks. The basal diet contained adequate amounts of all other required nutrients. For foods containing milk protein as the main ingredient, the protein efficiency ratio (PER) expressed as percentage of ANRC casein was from 41 to 129. PER of milk-egg blends with different matrices was from 89 to 124%. Soya protein isolate, defatted groundnut protein and wheat protein isolate had PER values of 72, 56 and 0%, respectively. Autolysed yeast and blue-green algae had values of 66 and 78%. PER values of non-defatted and defatted liver powder were 33 and 69%. PER values were positively associated with plasma total protein and albumin values and negatively associated with blood urea nitrogen values. Enlarged organs and increased deposition of liver lipid were noted in rats given some of the test samples. The protein content and protein quality of the protein foods or ingredients varied greatly, demonstrating the need for continued evaluations.
KW - Milk protein
KW - nutritive value
KW - protein quality
KW - Protein sources
KW - quality
KW - rat feeding
KW - soya protein
KW - wheat
KW - Wheat protein
KW - Rats
KW - Triticum
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - nutritional value
KW - quality for nutrition
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - Food Composition and Quality (QQ500)
KW - Animal Nutrition (General) (LL500)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891412957&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo.
AU - Prasanna, H. R.
AU - Lu, M. H.
AU - Beland, F. A.
AU - Hart, R. W.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1989///
VL - 10
IS - 12
SP - 2197
EP - 2200
SN - 0143-3334
AD - Prasanna, H. R.: National Center for Toxicological Research, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19901206561. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9007-49-2, 53-43-0. Subject Subsets: Medical & Veterinary Mycology
N2 - The protection of hepatic DNA by dehydroepiandrosterone [prasterone] (DHEA) from damage by aflatoxin B1 (AFB1) was investigated. Young male Fischer 344 (2-month-old) rats were fed a diet containing 0.8% DHEA for 14 d. Control rats were pair-fed the same diet without DHEA. The rats were then administered a single intraperitoneal dose of [³H]AFB1 in dimethylsulfoxide (0.6 mg/kg body weight; 200 mCi/mmol) and killed after 3 h. Liver weight, mitochondrial, microsomal and cytosolic protein, cytochrome P450 content and glutathione transferase activity increased significantly (P<0.001) in DHEA-fed rats; however, the hepatic DNA content was not altered. DHEA feeding increased the total amount of AFB1 bound to hepatic protein but decreased the extent of DNA binding. In in vitro experiments, there was less total binding to DNA and protein by AFB1 when using microsomes from DHEA-fed rats. It is suggested that DHEA inhibits the binding of AFB1 to DNA by modifying the biotransformation of the carcinogen.
KW - Aflatoxins
KW - binding
KW - diet
KW - DNA
KW - inhibition
KW - Mycotoxins
KW - poisoning
KW - prasterone
KW - susceptibility
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dehydroepiandrosterone
KW - deoxyribonucleic acid
KW - fungal toxins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206561&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Site-specific ribosomal DNA insertion elements in Anopheles gambiae and A. arabiensis: nucleotide sequence of gene-element boundaries.
AU - Paskewitz, S. M.
AU - Collins, F. H.
JO - Nucleic Acids Research
JF - Nucleic Acids Research
Y1 - 1989///
VL - 17
IS - 20
SP - 8125
EP - 8133
SN - 0305-1048
AD - Paskewitz, S. M.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910502336. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The nucleotide sequence of the junctions between the 28S ribosomal gene and site-specific insertion elements from 2 sibling mosquito species, A. gambiae and A. arabiensis, is reported. In both species, elements insert at the same point within the 28S gene, but this site is 634 basepairs (bp) 3′ of the R1 (Type 1) insertion site in Drosophila melanogaster. The 2 mosquito elements each have poly A tails and a polyadenylation signal, but the extreme 3′ and 5′ ends show no other similarity to each other or to any other insertion element. In both mosquito species, identical target site duplications of 17 bp are generated. The sequence TNTCCCTNT found in this duplication is also found in the 14 bp target site duplications that flank R1 elements in D. melanogaster. Another sequence in this duplication, GGGATAACT, is very similar to the sequence GGGAGTAACTA found in the 24 base sequence required by the Bombyx mori R2 endonuclease.
KW - Genes
KW - molecular genetics
KW - nucleotide sequences
KW - ribosomal DNA
KW - Sibling species
KW - Anopheles
KW - Anopheles arabiensis
KW - Anopheles gambiae
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - biochemical genetics
KW - DNA sequences
KW - mosquitoes
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910502336&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of zearalenol and zearalenone using electrochemical detection.
AU - Ware, G. M.
AU - Francis, O. J.
AU - Kuan, S. S.
AU - Carman, A. S.
JO - Analytical Letters
JF - Analytical Letters
Y1 - 1989///
VL - 22
IS - 10
SP - 2335
EP - 2352
SN - 0003-2719
AD - Ware, G. M.: Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122, USA.
N1 - Accession Number: 19911208903. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 5916-52-9, 17924-92-4. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research; Animal Nutrition; Human Nutrition; Maize
N2 - A method is described for the determination of zearalenol and zearalenone in maize using electrochemical detection. The sample is extracted with chloroform and the extract is cleaned up by liquid-liquid partition. Zearalenol and zearalenone are resolved by liquid chromatography (LC), using a C18 column and a mobile phase consisting of 35:25:40 CH3CN:MeOH:H2O and 0.02 mole/litre sodium acetate buffered at pH 6.5. Zearalenol and zearalenone were detected with an electrochemical detector at an applied potential of +0.95V vs. Ag/AgCl. Mean recoveries of zearalenol and zearalenone in maize samples spiked at levels of 25-1000 ng/g were 104.2 and 97.5%, respectively. The coefficients of variation for the proposed method were 10.8% for zearalenol and 8.8% for zearalenone.
KW - biodeterioration
KW - contamination
KW - determination
KW - estimation
KW - liquid chromatography
KW - maize
KW - Mycotoxins
KW - techniques
KW - Zearalenol
KW - Zearalenone
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - f-2 toxin
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance for dengue and dengue hemorrhagic fever.
AU - Gubler, D. J.
JO - Bulletin of the Pan American Health Organization
JF - Bulletin of the Pan American Health Organization
Y1 - 1989///
VL - 23
IS - 4
SP - 397
EP - 404
SN - 0085-4638
AD - Gubler, D. J.: San Juan Laboratories, Division of Vector-borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, San Juan, Puerto Rico.
N1 - Accession Number: 19910507194. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - The increasing importance of dengue and dengue haemorrhagic fever in tropical countries is discussed with particular reference to the situation in the Americas and the dengue surveillance and prevention campaign in Puerto Rico. It is considered that virological surveillance (the monitoring of dengue viruses in an area during interepidemic periods and of the geographical distribution and movement of all dengue virus serotypes and the types of illness associated with dengue infection in an endemic area) is the most important component in any programme, although epidemiological surveillance (the reporting of dengue and fevers of unknown origin by physicians), clinical surveillance (surveillance for viral fevers with a haemorrhagic or fatal outcome), serological surveillance (using ELISA for the detection of anti-dengue virus IgM antibodies) and entomological surveillance (monitoring of Aedes aegypti population densities, larval habitats and insecticide susceptibility) are also important. [This paper has also been published in Spanish in the Boletín de la Oficina Sanitaria Panamericana, 107: 22-30 (1989)].<new para>ADDITIONAL ABSTRACT:<new para>Dengue and dengue hemorrhagic fever are emerging as major public health problems in most tropical countries. Effective prevention and control programs will depend on improved surveillance designed to provide early warning of dengue epidemics. This article outlines a reasonable approach to dengue surveillance of this kind.Virologic surveillance should be considered the most important element in any such early warning system. Dengue virus transmission should be monitored to determine which serotypes are present, their distribution, and the type of illnesses associated with each. Other key components of an active surveillance system should include monitoring of fever activity and clinical surveillance for cases of severe and fatal disease associated with viral syndromes. Collectively, these 3 surveillance components can provide an early warning capability permitting emergency mosquito control measures to be implemented and major epidemics to be averted.AS
KW - Arboviruses
KW - Dengue
KW - Disease surveys
KW - disease vectors
KW - epidemics
KW - epidemiology
KW - Human diseases
KW - Monitoring
KW - Mosquito-borne diseases
KW - Serological surveys
KW - surveillance
KW - Vectors
KW - Viral diseases
KW - America
KW - Caribbean
KW - Central America
KW - Puerto Rico
KW - Aedes aegypti
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - America
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Latin America
KW - America (North)
KW - America (South)
KW - arthropod-borne viruses
KW - disease surveillance
KW - mosquitoes
KW - Porto Rico
KW - seroepidemiology
KW - surveillance systems
KW - viral infections
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910507194&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Tick-borne relapsing fever in Israel, 1978-87.
AU - Lidror, R.
AU - Slater, P. E.
T2 - Israel Journal of Medical Sciences
JO - Israel Journal of Medical Sciences
JF - Israel Journal of Medical Sciences
Y1 - 1989///
VL - 25
IS - 1
SP - 59
EP - 59
SN - 0021-2180
AD - Lidror, R.: Department of Environmental Health, Public Health Service, Ministry of Health, Jerusalem, Israel.
N1 - Accession Number: 19900597661. Publication Type: Conference paper. Language: English. Subject Subsets: Medical & Veterinary Entomology
KW - epidemiology
KW - Human diseases
KW - Tickborne diseases
KW - tickborne relapsing fever
KW - Asia
KW - Israel
KW - Middle East
KW - Acari
KW - Arachnida
KW - Borrelia
KW - man
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Developed Countries
KW - Mediterranean Region
KW - Middle East
KW - West Asia
KW - Asia
KW - bacterium
KW - Near East
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597661&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maintaining mosquito cell lines at high temperatures: effects on the replication of flaviviruses.
AU - Kuno, G.
AU - Oliver, A.
JO - In Vitro Cellular & Developmental Biology
JF - In Vitro Cellular & Developmental Biology
Y1 - 1989///
VL - 25
IS - 2
SP - 193
EP - 196
SN - 0883-8364
AD - Kuno, G.: Dengue Branch, Division of Vector-Borne Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health & Human Services, San Juan, 00936, Puerto Rico.
N1 - Accession Number: 19890596557. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The upper thermal limit for maintenance of 11 mosquito cell lines (Aedes aegypti AGY101, AGY502, ATP-10 and RML-12, A. albopictus C6/36, A. pseudoscutellaris Mos61, Anopheles gambiae Mos55, A. stephensi Mos43, Culex tarsalis, Haemagogus equinus and Toxorhynchites amboinensis TRA-284) was studied. The following flaviviruses adapted to cell culture were used for virus replication study: dengue (DEN) virus type 1 (Hawaii), DEN-2 (New Guinea "C"), DEN-3 (H-87), DEN-4 (H-241), Japanese encephalitis virus (JE;5-3 attenuated strain), St. Louis encephalitis virus (SLE P-15) and yellow fever virus (YF; 17D strain). Although most cell lines could be grown at 32-34°C, the A. stephensi cell line could be maintained at 37°C. At higher temperatures initial growth rate was higher, but yield of cells after about a week of incubation was lower than at the standard temperature (28°C). Replication of several flaviviruses in Aedes albopictus cell cultures adapted to 34.5°C was faster, and viral tires were higher than at 28°C.
KW - Arboviruses
KW - cell lines
KW - infection
KW - Temperature
KW - Aedes aegypti
KW - Aedes albopictus
KW - Aedes pseudoscutellaris
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Culex tarsalis
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Haemagogus equinus
KW - Japanese encephalitis virus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Toxorhynchites amboinensis
KW - Yellow fever virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Culex
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Haemagogus
KW - Toxorhynchites
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890596557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Western equine encephalitis in avian populations in North Dakota, 1975.
AU - McLean, R. G.
AU - Shriner, R. B.
AU - Kirk, L. J.
AU - Muth, D. J.
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
Y1 - 1989///
VL - 25
IS - 4
SP - 481
EP - 489
SN - 0090-3558
AD - McLean, R. G.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990500273. Publication Type: Journal Article. Language: English. Number of References: 25 ref.
N2 - The involvement of wild birds in western equine encephalitis (WEE) and St. Louis encephalitis (SLE) virus activity in the Red River valley area of North Dakota, USA, during a WEE epidemic was investigated in August 1975. Free-ranging birds were captured with mist nets and nestlings by hand. Virologic and serologic results indicated that a similar rate of WEE virus activity occurred throughout Richland County and between permanent and summer resident birds. The rate of SLE virus activity in the birds of Richland County was lower than for WEE virus, but the SLE antibody prevalence was greater in rural areas than within urban locations. 7 of the 9 WEE virus isolations were from nestling birds of 4 different species; the remaining 2 from adults of 2 different species. Overall prevalence of neutralizing (N) antibody against WEE virus was 5% in nestling and 14% in adult birds, but was the opposite for N antibody against SLE virus, 17% in nestling and 5% in adult birds. Differences between the two viruses in the presence and persistence of maternal N antibody or differential mortality in nestling birds may have caused the disparity in antibody prevalences.
KW - arboviruses
KW - rural areas
KW - serology
KW - seroprevalence
KW - St Louis encephalitis
KW - urban areas
KW - wild animals
KW - wild birds
KW - North Dakota
KW - USA
KW - birds
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - western equine encephalitis virus
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - arthropod-borne viruses
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500273&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inability of diapausing Culex pipiens (Diptera: Culicidae) to use blood for producing lipid reserves for overwinter survival.
AU - Mitchell, C. J.
AU - Briegel, H.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1989///
VL - 26
IS - 4
SP - 318
EP - 326
SN - 0022-2585
AD - Mitchell, C. J.: Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900597162. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Diapausing females of C. pipiens fed 10% sucrose for 7 days following eclosion contained significantly more lipids (P < 0.05) than non-diapausing females reared and maintained at the same temperature (22°C) but at a longer photophase (LD 14:10 instead of 9:15). Diapausing females with limited lipid reserves failed to increase their reserves after blood feeding. The average lipid content of 56 females tested decreased significantly (P < 0.05) by day 6 after feeding and there was no correlation (r = -0.06) between lipid content at this time and original blood-meal volumes of individual females. These results refute the contention that blood-meals taken by diapausing C. pipiens result in fat body development when females are incubated at 18°C during blood-meal digestion. Diapausing C. pipiens with limited lipid reserves were unable to obtain sufficient energy from a single blood-meal to survive extended hibernation. Although none became gravid, only 50% remained alive after 20 days in hibernation. In contrast, non-blood-fed females fed only 10% sucrose for 7-10 days before being placed in hibernation on a water diet survived for 6 months with only 50% mortality. There was no evidence for gonotrophic dissociation. Failure of blood-fed, diapausing females to initiate vitellogenesis was correlated with the significantly smaller blood-meals taken by most diapausing females and not with hypertrophy of the fat body or temperature during digestion.
KW - Biochemistry
KW - Blood-meals
KW - diapause
KW - Digestion
KW - Gonotrophic cycles
KW - Haematophagy
KW - Lipids
KW - Nutrition
KW - overwintering
KW - physiology
KW - Sugars
KW - Vitellogenesis
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - blood feeding
KW - hematophagy
KW - lipins
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597162&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fate of the blood meal in force-fed, diapausing Culex pipiens (Diptera: Culicidae).
AU - Mitchell, C. J.
AU - Briegel, H.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1989///
VL - 26
IS - 4
SP - 332
EP - 341
SN - 0022-2585
AD - Mitchell, C. J.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900597164. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Diapausing C. pipiens do not display host-seeking behaviour and can be induced to take blood only by being placed in contact with or in proximity to a host for prolonged periods. Such 'force-fed' females do not use the blood for lipogenesis, and only some of them use the blood to initiate vitellogenesis. Diapausing C. pipiens that are induced to feed eject an average of 4.2-4.6 µl of blood during overnight feeding periods compared with an average of 0.1 µl for non-diapausing controls. The reduced avidity of diapausing females for blood, even under optimal conditions, and the ejection by fed females of blood volumes usually retained indicate that such females are not physiologically programmed for taking and retaining blood. Data for uric acid and haematin excretion and blood-meal volumes retained by diapausing females are positively correlated with diapause termination and yolk deposition. The occurrence of gonotrophic dissociation need not be invoked to explain the failure of some diapausing females to initiate vitellogenesis following a blood-meal. Instead, this is explained by retention of small quantities of blood followed by incomplete digestion and is the expected result of a dose-dependent phenomenon determined by threshold blood volumes. The data support the concept that the overwintering strategy of C. pipiens is limited to gonotrophic concordance in which overwintering females in nature do not take blood or develop eggs until diapause is terminated.
KW - blood-meals
KW - diapause
KW - Digestion
KW - Excretion
KW - Gonotrophic cycles
KW - Haematophagy
KW - Nutrition
KW - physiology
KW - Vitellogenesis
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - blood feeding
KW - hematophagy
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597164&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of DNA hybridization probes for detection of the plague bacillus (Yersinia pestis) in fleas (Siphonaptera: Pulicidae and Ceratophyllidae).
AU - Thomas, R. E.
AU - McDonough, K. A.
AU - Schwan, T. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1989///
VL - 26
IS - 4
SP - 342
EP - 348
SN - 0022-2585
AD - Thomas, R. E.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19900597165. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2 - The detection of active plague in nature relies primarily on demonstration of the aetiologic agent of the disease, Y. pestis, in the flea vectors and susceptible mammalian hosts. A live animal assay is currently used for identification of a Y. pestis virulence antigen that is not expressed in the flea. It was found that DNA hybridization probes specific for Y. pestis, used in very simple sample preparation schemes, allow detection of Y. pestis in 3 species of fleas as well as tissues of experimentally infected mice at minimum concentrations of 1×106 bacillus/ml. Y. pestis was detected in 22 of 90 (24%) experimentally infected Xenopsylla cheopis, 13 of 25 (52%) Thrassis bacchi and 9 of 25 (36%) Diamanus montanus [Oropsylla montana], but no hybridization signals were observed from fleas that had fed on uninfected mice. The probe technique indicated infection in 9 of 10 potentially infected liver and spleen samples and none of the 5 control samples. The techniques permit definite diagnosis in 48 h.
KW - Biotechnology
KW - detection
KW - Diagnosis
KW - DNA probes
KW - Infections
KW - Laboratory animals
KW - Plague
KW - Techniques
KW - vectors
KW - Bacteria
KW - Ceratophyllidae
KW - Diamanus
KW - Diamanus montanus
KW - Mice
KW - Oropsylla
KW - Pulicidae
KW - Siphonaptera
KW - Xenopsylla cheopis
KW - Yersinia pestis
KW - prokaryotes
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ceratophyllidae
KW - Xenopsylla
KW - Pulicidae
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Diamanus
KW - Oropsylla
KW - bacterium
KW - Oriental rat flea
KW - Oropsylla montana
KW - Thrassis bacchi
KW - Yersinia pseudotuberculosis subsp. pestis
KW - Techniques and Methodology (ZZ900)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of pesticide residues in food with a 6% cyanopropylphenyl capillary column.
AU - Daft, J. L.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 1989///
VL - 27
IS - 2
SP - 75
EP - 78
SN - 0021-9665
AD - Daft, J. L.: US Dep. Health and Human Services, Food and Drug Administration, Kansas City, MO 64106, USA.
N1 - Accession Number: 19891413237. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 117-18-0. Subject Subsets: Human Nutrition; Potatoes
N2 - A small-diameter 6% cyanopropylphenyl column was studied for its suitability for estimating pesticides in food. Repeatability and linearity were satisfactory, and the column was capable of separating residue combinations that are known not to separate on methyl silicone columns. At 150° or 130°C, the column satisfactorily separated 5 byproducts of tecnazene, a growth regulator and sprout suppressant found in potatoes, and 4 byproducts of quintozene, a soil and seed fungicide found in groundnut products.
KW - determination
KW - estimation
KW - Pesticide residues
KW - residues
KW - Techniques
KW - tecnazene
KW - 2,3,5,6-tetrachloronitrobenzene
KW - TCNB
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891413237&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional and pathological changes in male and female rats fed modifications of the AIN-76A diet.
AU - Mitchell, G. V.
AU - Dua, P. N.
AU - Jenkins, M.
AU - Grundel, E.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1989///
VL - 27
IS - 3
SP - 185
EP - 191
SN - 0278-6915
AD - Mitchell, G. V.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901420224. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Sprague-Dawley rats were given an AIN-76A diet or a modification of the AIN-76A diet containing no added DL-methionine but with more vitamins, fluoride and magnesium than in the AIN-76A diet. Both diets were given to groups of 10 rats of each sex at 18% protein or with only 13% for 12 weeks. Within sex, all diets produced comparable weight gains in rats at 12 weeks except that the reduced-protein modified AIN-76A diet was associated with a reduction in weight gain in male rats. Both diet and protein level had significant effects on the relative weights of some organs, particularly the kidney. The AIN-76A and the reduced-protein AIN-76A diets increased the relative kidney weights (% body weights) of female rats, when compared with the effects of both modified AIN-76A diets (18 and 13% protein). Male rats on both diets containing 18% protein had higher relative kidney weights than did those eating both 13% protein diets. Females fed on the modified diet containing 13% protein had lower liver weights than the other groups. In both sexes, the diets containing 18% protein produced higher plasma urea nitrogen concentrations that did the lower-protein diets. Kidney calcium concentrations varied with the diet, with dietary protein, and with the sex of the rat. All diets caused small mineral (calcific) concretions of minimal to mild severity in the lumina of scattered renal tubules in the cortex and/or medulla of male rats. All female rats fed on the AIN-76A and the reduced-protein AIN-76A diet had large, moderate or severe mineral concretions in the tubules at the corticomedullary junction and this was associated with increased renal calcium values. The higher concentration of renal Ca at the lower dietary protein level (13%) was associated with severe corticomedullary junction mineralization. The higher-protein diets were associated with an increased incidence of hyaline droplets in the cytoplasm of kidney cortical tubules in male rats.
KW - Nephrocalcinosis
KW - protein intake
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901420224&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of quantitative immunofluorescence to clinical serology: antibody levels of Toxoplasma gondii.
AU - Kaplan, D. S.
AU - Picciolo, G. L.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1989///
VL - 27
IS - 9
SP - 2008
EP - 2013
SN - 0095-1137
AD - Kaplan, D. S.: Center for Devices and Radiological Health, Food and Drug Administration, 12200 Wilkins Avenue, Rockville, MD 20852, USA.
N1 - Accession Number: 19900859127. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Public Health
N2 - A quantitative immunofluorescence (QIF) method (which uses a calibrated photometric system and incorporates reducing agents into the mounting medium to reduce fading) was developed to replace the visual method of endpoint determination. A uranyl glass slide was used to calibrate the instrument's voltage measurements, permitting daily comparisons and measurement of the instrument reading fluctuations. The QIF method was initially tailored to the determination of serum antibodies to T. gondii by measuring the fluorescence intensity of individual tagged organisms. The QIF method showed a 94% correlation with the visual comparison method for 62 clinical specimens.
KW - detection
KW - Human diseases
KW - immunodiagnosis
KW - immunofluorescence
KW - parasites
KW - Apicomplexa
KW - man
KW - protozoa
KW - Toxoplasma gondii
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - fluorescent antibody technique
KW - IFAT
KW - quantitative immunofluorescence
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Study of the teratogenic potential of FD & C Red No. 40 when given by gavage to rats.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Welsh, J. J.
AU - Brown, L. H.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1989///
VL - 27
IS - 11
SP - 707
EP - 713
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901419259. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - Osborne-Mendel rats were intubated with FD & C Red No. 40 at 0, 30, 75, 150, 300, 600 or 1000 mg/kg body weight daily on days 0 to 19 of pregnancy. No toxicity was evident when rats were killed on day 20 of pregnancy. No dose-related changes were seen in maternal daily observations, food consumption, body weight gain or implantations, or in foetal viability, body weight, body length, sex distribution or external variations. Skeletal and soft-tissue development were similar in foetuses of all groups. The isolated increases in the number of male foetuses, number of females with 2 or more resorptions, number of litters with 3 or more sternebral variations and incidence of 14th rib bud are considered random occurrences and were not related to dosage.
KW - Food colourants
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food colorants
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901419259&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of gas chromatography/matrix isolation/Fourier transform infrared spectrometry to the identification of glucosinolates from Brassica vegetables.
AU - Mossoba, M. M.
AU - Shaw, G. J.
AU - Andrzejewski, D.
AU - Sphon, J. A.
AU - Page, S. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1989///
VL - 37
IS - 2
SP - 367
EP - 372
SN - 0021-8561
AD - Mossoba, M. M.: Division of Contaminants Chemistry, Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19891420203. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Horticultural Science
N2 - There is limited epidemiological evidence suggesting that ingestion of Brassica vegetables may be associated with reduced risk of some cancers of the alimentary tract, and a number of Brassica constituents are known to inhibit carcinogenesis in laboratory animals. The components that are responsible for the observed protective activity and the effects of processing on them have not yet been established. An analytical method using capillary gas chromatography/matrix isolation/Fourier transform infrared spectroscopy (GC/MI/FT-IR) was developed for characterizing intact glucosinolates extracted from Brussels sprouts and rutabaga (swede). Highly resolved gas chromatograms and diagnostic MI/FT-IR spectra were obtained for different glucosinolate analogues with subtle structural differences.
KW - Brussels sprouts
KW - composition
KW - determination
KW - estimation
KW - glucosinolates
KW - Swedes
KW - vegetables
KW - Brassica
KW - Brassica napus var. napobrassica
KW - Brassica oleracea var. gemmifera
KW - Brassicaceae
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Brassica napus
KW - Brassica
KW - Brassica oleracea
KW - Capparales
KW - plant
KW - rutabagas
KW - vegetable crops
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891420203&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Separation and identification of glucosinolates from Brassica vegetables using high-performance capillary gas chromatography (GC)-positive-ion chemical ionization mass spectrometry (PICIMS) and GC-PICIMS/MS.
AU - Shaw, G. J.
AU - Andrzejewski, D.
AU - Roach, J. A. G.
AU - Sphon, J. A.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1989///
VL - 37
IS - 2
SP - 372
EP - 378
SN - 0021-8561
AD - Shaw, G. J.: D. Andrzejewski, Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891420204. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Horticultural Science
KW - composition
KW - determination
KW - estimation
KW - glucosinolates
KW - vegetables
KW - Brassica
KW - Brassicaceae
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Capparales
KW - plant
KW - vegetable crops
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891420204&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of fumigants and related chemicals in fatty and nonfatty foods.
AU - Daft, J. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1989///
VL - 37
IS - 2
SP - 560
EP - 564
SN - 0021-8561
AD - Daft, J. L.: Dep. Health and Human Services, Food and Drug Administration, 1009 Cherry Street, Kansas City, MO 64106, USA.
N1 - Accession Number: 19891420208. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Mean recoveries for 22 fumigants and related industrial chemicals were estimated from various fatty and non-fatty foods by liquid extraction and gas chromatography. The overall mean recovery was 73% from fatty foods and 78% from non-fatty foods; the recovery from both sample types after further cleanup by Florisil chromatography was 55%. Actual fumigant residues were also estimated in 549 samples examined; 849 residues were found in 372 samples; no residues were found in 177 samples. Findings were sorted and cross-referenced by sample type, i.e., fat, non-fat, grain-based, and non-grain-based. Findings included 10 different residues: carbon disulphide, carbon tetrachloride, chloroform, chloropicrin, ethylene dibromide, ethylene dichloride, methylene chloride, methylchloroform, tetrachloroethylene and trichloroethylene. Mean finding amounts ranged from 7 to 799 ng/g. The average number of findings per fat and non-fat sample was 2.31 and 0.72 and per grain-based and non-grain-based sample was 2.22 and 1.04, respectively.
KW - estimation
KW - Foods
KW - pesticide residues
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891420208&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of trans-diene isomers in hydrogenated soybean oil by gas chromatography, silver nitrate thin-layer chromatography, and 13C NMR spectroscopy.
AU - McDonald, R. E.
AU - Armstrong, D. J.
AU - Kreishman, G. P.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1989///
VL - 37
IS - 3
SP - 637
EP - 642
SN - 0021-8561
AD - McDonald, R. E.: Division of Food Chemistry and Technology, Food Engineering Branch, Food and Drug Administration, 1090 Tusculum Avenue, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19891416079. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 8001-22-7. Subject Subsets: Human Nutrition; Soyabeans
N2 - Soyabean oil was hydrogenated using a sulphur-containing nickel catalyst to produce large amounts of trans-diene isomers. The isomers were derivatized to methyl esters and then fractionated by preparative silver nitrate thin-layer chromatography (TLC). Each TLC band was recovered and analysed by capillary gas chromatography (GC). The identity of specific trans-dienes was confirmed by 13C nuclear magnetic resonance (13C NMR). Packed-column GC using a 6.1 m × 2 mm OV-275 column gave an accurate indication of the total amount of trans-dienes present, while a 50 m × 0.22 mm capillary column containing (cyanopropyl)polysiloxane separated the individual trans-diene isomers. By 13C NMR, the 3 major trans-diene isomers were identified as cis-9,trans-12-octadecadienoic acid, trans-9,cis-12-octadecadienoic acid, and trans-9,trans-12-octadecadionois acid.
KW - analysis
KW - Hydrogenated oils
KW - Soyabean oil
KW - soybean oil
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891416079&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protein efficiency ratios and net protein ratios of selected protein foods.
AU - Mitchell, G. V.
AU - Jenkins, M. Y.
AU - Grundel, E.
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
Y1 - 1989///
VL - 39
IS - 1
SP - 53
EP - 58
SN - 0921-9668
AD - Mitchell, G. V.: Food and Drug Administration, Experimental Nutrition Branch (HFF-268), Division of Nutrition, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901417652. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Rice; Wheat, Barley & Triticale Abstracts
N2 - As a part of a cooperative study initiated to assess in vitro protein quality methods, the protein efficiency ratio (PER) and net protein ratios (NPR) of 15 different protein sources were estimated. Male weanling Sprague-Dawley rats were fed on a 10% protein diet. NPR and relative NPR (RNPR) values at 14 days and PER and relative PER (RPER) values at 14 and 28 days were calculated for each protein source. When protein quality values were expressed relative to ANRC casein, the 14- and 28-day PER ranked the protein sources essentially in the same order. RPER values of non-fat dried skimmed milk (unheated) and tuna were more than 100% that of casein; non-fat dried skimmed milk (heated), chickpeas and breakfast sausage were between 50 and 70% of that of casein; pinto beans and rice/wheat gluten cereal did not support substantial growth of rats. The NPR method did not always rank the protein sources in the same order as the PER method. For the poor-quality proteins, RNPR values were much higher than the RPER values; however, the RNPR and RPER values agreed closely for high-quality protein sources.
KW - estimation
KW - Nutrition
KW - Protein quality
KW - wheat
KW - rats
KW - Triticum
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417652&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro prediction of iron bioavailability for food fortification.
AU - Whittaker, P.
AU - Fox, M. R. S.
AU - Forbes, A. L.
JO - Nutrition Reports International
JF - Nutrition Reports International
Y1 - 1989///
VL - 39
IS - 6
SP - 1205
EP - 1215
AD - Whittaker, P.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19901417688. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - A simulated gastrointestinal digestive system was used to compare in vitro dialysability of FePO4.2H2O and electrolytic iron with that of FeSO4.7H2O as a reference in a farina cereal meal and in standard purified rat and guineapig diets. The system, in which Fe passes from an enzymic digest into dialysis tubing containing NaHCO3, was adapted to assess the bioavailability of standard forms of Fe fortification. Mean (± s.e.) dialysed Fe values from FeSO4 in the 3 diets were 1.46 ± 0.04, 2.69 ± 0.14 and 1.71 ± 0.05%, respectively. The mean relative dialysability range was 0.71 to 0.73 for electrolytic Fe and 0.14 to 0.47 for FePO4. The possible enhancing effects of added Na2EDTA and vitamin C were also assessed with FeSO4. The percentage dialysed Fe was similar for FeSO4 + EDTA (1:1 molar ratio) and NaFe(III)EDTA in each meal. Mean values were 26.6 and 25.9% (farina), 23.9 and 22.8% (rat), and 17.9 and 18.4% (guineapig) for FeSO4 + EDTA and NaFeEDTA, respectively. A 1:1 molar ratio of FeSO4 + vitamin C produced 16.2, 14.9 and 14.2% dialysed Fe and a 1:2 ratio produced 23.5, 17.5 and 17.8% for the 3 diets, respectively. The addition of 2 mol vitamin C was required to approximate the enhancing effect of 1 mol EDTA. The in vitro method provides a simple screening tool which may be valuable in assessing Fe bioavailability for fortification purposes.
KW - availability
KW - diets
KW - fortification
KW - Iron
KW - Techniques and Methodology (ZZ900)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417688&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The ecology of Colorado tick fever in Rocky Mountain National Park in 1974. III. Habitats supporting the virus.
AU - McLean, R. G.
AU - Shriner, R. B.
AU - Pokorny, K. S.
AU - Bowen, G. S.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1989///
VL - 40
IS - 1
SP - 86
EP - 93
SN - 0002-9637
AD - McLean, R. G.: Division of Vector-Borne Viral Diseases, Center for Infectious Disease, Centers for Disease Control, Public Health Service, US Dep. Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19890594163. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Ecological studies of small mammals in Rocky Mountain National Park (RMNP), Colorado, were conducted in 1974 in order to identify the specific habitats within the Lower Montane Forest that support Colorado tick fever (CTF) virus. Data was collected on the abundance and distribution of 4 primary rodent species (Peromyscus maniculatus, Tamias minimus, Spermophilus lateralis and S. richardsoni), tick (Dermacentor andersoni) infestation, CTF virus, and neutralizing antibody prevalence. Rodents were captured along transects crossing different habitats. Open stands of ponderosa pine (Pinus ponderosa) and shrubs on dry rocky surfaces were found to be important for maintaining CTF virus.<new para>ADDITIONAL ABSTRACT:<new para>Ecologic studies of small mammals in Rocky Mountain National Park (RMNP) were conducted in 1974 in order to identify the specific habitats within the Lower Montane Forest that support Colorado tick fever (CTF) virus. Data was collected on the abundance and distribution of 4 primary rodent species, tick infestation, CTF virus, and neutralizing antibody prevalence. Rodents were captured along transects crossing different habitats. Open stands of ponderosa pine and shrubs on dry, rocky surfaces were found to be important for maintaining CTF virus.AS
KW - Arboviruses
KW - epidemiology
KW - infections
KW - Tickborne diseases
KW - viral diseases
KW - Colorado
KW - North America
KW - USA
KW - Acari
KW - Arachnida
KW - Colorado tick fever virus
KW - Dermacentor andersoni
KW - Ixodidae
KW - Muridae
KW - Orbivirus
KW - Peromyscus maniculatus
KW - Reoviridae
KW - rodents
KW - Sciuridae
KW - Spermophilus elegans
KW - Spermophilus lateralis
KW - Spermophilus richardsonii
KW - Tamias minimus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Peromyscus
KW - Sigmodontinae
KW - Muridae
KW - Spermophilus
KW - Sciuridae
KW - Tamias
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - America (North)
KW - arthropod-borne viruses
KW - Colorado tick fever
KW - Sciurinae
KW - Spermophilus richardsoni
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890594163&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis.
AU - Eberhard, M. L.
AU - Lammie, P. J.
AU - Roberts, J. M.
AU - Lowrie, R. C., Jr.
JO - Tropical Medicine and Parasitology
JF - Tropical Medicine and Parasitology
Y1 - 1989///
VL - 40
IS - 2
SP - 111
EP - 113
SN - 0177-2392
AD - Eberhard, M. L.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900861059. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 90-89-1, 1642-54-2. Subject Subsets: Helminthology; Tropical Diseases
N2 - Forty-seven Wuchereria bancrofti microfilaria carriers in Haiti, were treated once weekly for 12 weeks with 6 mg/kg diethylcarbamazine citrate (DEC-C). Microfilaria densities ranged from 1 to 101 mf/20 mm³ (MfD-50 of 9.75 mf/20 mm³) before treatment. Of 42 persons who completed treatment, 26 were microfilaria negative in 1-ml venous blood samples. Microfilaria densities in the 16 patients that remained positive ranged from 1 to 50 mg/ml (MfD-50 of 2.59 mf/ml). Weekly spaced doses of DEC-C resulted in a significant reduction in the number of microfilaria carriers posttreatment, and in the level of residual microfilaraemia when compared to daily administration of the drug. Administration of spaced doses of DEC-C also resulted in better patient compliance with less dropout from the programme. The reason DEC-C is more effective in spaced doses still remains unclear, but the role platelets or other cells may play in mediating the action of the drug may be linked to the administration schedule.<new para>ADDITIONAL ABSTRACT:<new para>Forty-seven Wuchereria bancrofti microfilaria carriers were treated [in Haiti] once weekly for 12 weeks with 6 mg/kg DEC-C. Microfilaria densities ranged from 1 to 101 mf/20 mm³ (MfD-50 of 9.75 mf/20 mm³) before treatment. Of 42 persons who completed treatment, 26 (62%) were microfilaria negative in 1-ml venous blood samples. Microfilaria densities in the 16 patients that remained positive ranged from 1 to 50 mf/ml (MfD-50 of 2.59 mf/ml). Weekly spaced doses of DEC-C resulted in a significant reduction in the number of microfilaria carriers posttreatment, and in the level of residual microfilaremia when compared to daily administration of the drug. Administration of spaced doses of DEC-C also resulted in better patient compliance with less dropout from the program. The reason DEC-C is more effective in spaced doses still remains unclear, but the role platelets or other cells may play in mediating the action of the drug may be linked to the administration schedule.AS
KW - Anthelmintics
KW - bancroftian filariasis
KW - citrates
KW - diethylcarbamazine
KW - dosage
KW - DRUG THERAPY
KW - Filariids
KW - helminths
KW - Human diseases
KW - parasites
KW - treatment
KW - Caribbean
KW - Haiti
KW - man
KW - Nematoda
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Wuchereria
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - chemotherapy
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - spaced
KW - Spirurida
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900861059&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer.
AU - Layde, P. M.
AU - Webster, L. A.
AU - Baughman, A. L.
AU - Wingo, P. A.
AU - Rubin, G. L.
AU - Ory, H. W.
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 1989///
VL - 42
IS - 10
SP - 963
EP - 973
SN - 0895-4356
AD - Layde, P. M.: US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta, GA 30333, USA.
N1 - Accession Number: 19901452576. Publication Type: Journal Article. Corporate Author: USA, Cancer and Steroid Hormone Study Group Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Although the important influence of a woman's reproductive history on her risk of breast cancer is widely recognized, it is not clear whether this is wholly accounted for by the age at her first term pregnancy, or whether there are additional, independent influences of breast feeding or number of children. To examine the respective contributions to the risk of breast cancer of those reproductive factors, logistic regression methods were used to analyse data from a multicentre case-control study, the Cancer and Steroid Hormone Study. Included in the analysis were 4599 women, 20 to 55 years old, identified as having an initial diagnosis of breast cancer by one of 8 collaborating population-based cancer registries. The 4536 controls were women of similar ages selected by random dialling of households with telephones in the same 8 areas. As expected, age at first term pregnancy exerted a strong influence on the risk of breast cancer. However, after it and other potentially confounding factors had been controlled for, parity and duration of breast feeding also had a strong influence on the risk of breast cancer. Compared with women of parity 1, women of parity 7 or greater had an adjusted relative risk of breast cancer of 0.59. Compared with parous women who never breast fed, women who had breast fed for 25 months or more had an adjusted relative risk of 0.67. The results do not support the supposed pre-eminent importance of age at first term pregnancy among the reproductive determinants of breast carcinogenesis.
KW - breast feeding
KW - Carcinogenesis
KW - infants
KW - mammary gland neoplasms
KW - mammary glands
KW - pregnancy
KW - probability analysis
KW - reproduction
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - mammary tumour
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Diet Studies (VV110)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452576&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Age dependence of metals in hair in a selected U.S. population.
AU - Paschal, D. C.
AU - DiPietro, E. S.
AU - Phillips, D. L.
AU - Gunter, E. W.
JO - Environmental Research
JF - Environmental Research
Y1 - 1989///
VL - 48
IS - 1
SP - 17
EP - 28
AD - Paschal, D. C.: Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19891412469. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - Concentrations of 28 metals were estimated in hair samples from 199 children to 12 years old and 322 adults 13 to 73 years old. Calcium, barium, magnesium, zinc and strontium all showed a similar age-dependent increase up to about 12 to 14 years; aluminium showed a decrease with age. Relations of elemental concentrations with age were examined by using correlation, linear regression, t tests and discriminant analysis. Significant differences in mean concentration values between children and adults were shown for these metals. Discriminant analysis gave about 95% accuracy in classifying a test data set into the categories of children and adults. A hypothesis suggested by the data is that there is an age-dependent excretion in hair of alkali metals during skeletal growth and development. The observed decrease in Al is largely unexplained at this time.
KW - age
KW - hair
KW - Minerals
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891412469&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat.
AU - Duffy, P. H.
AU - Feuers, R. J.
AU - Leakey, J. A.
AU - Nakamura, K. D.
AU - Turturro, A.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 117
EP - 133
SN - 0047-6374
AD - Duffy, P. H.: HFT-1, Building 62, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901417194. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition
N2 - A number of physiological and behavioural measures related to metabolism were continuously monitored in male Fischer 344 rats 19 months old fed freely or on an energy-restricted diet. Energy-restricted rats ate fewer meals but consumed more food during each meal and spent more time eating per meal than did rats fed freely. Therefore, the timing and duration of meals as well as the total amount of energy consumed may be associated with life extension. Average body temperature per day was significantly lower in restricted rats but body temperature range per day and motor activity were higher in restricted rats. Dramatic changes in respiratory quotient, indicating rapid changes in metabolic pathway and lower temperature, occurred in energy-restricted rats when carbohydrate reserves were depleted. Lower body temperature and metabolism during this time may result in less DNA damage, thereby increasing the survival potential of restricted rats. Nighttime feeding synchronized physiological performance between freely fed and energy-restricted rats better than daytime feeding, thereby allowing investigators to distinguish the effects of energy restriction from those related only to the time-of-day of feeding.
KW - Energy intake
KW - energy metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417194&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. 1. The cytochrome P-450 dependent monooxygenase system.
AU - Leakey, J. E. A.
AU - Cunny, H. C.
AU - Bazare, J., Jr.
AU - Webb, P. J.
AU - Feuers, R. J.
AU - Duffy, P. H.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 145
EP - 155
SN - 0047-6374
AD - Leakey, J. E. A.: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901418911. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - The effects of long-term energy restriction on the hepatic cytochrome P-450 dependent monooxygenase system were investigated in Fischer 344 rats 22 months old. Energy restriction decreased the age-related changes in hepatic testosterone metabolism, which are associated with demasculinization of the liver. Energy restriction also increased hepatic microsomal testosterone 6β-hydroxylase, lauric acid 12-hydroxylase and 4-nitrophenol hydroxylase activities over corresponding values in freely fed rats 22 months and control male rats 60 days old. This suggests that cytochrome P-450 isozymes, P-450pcn1&2, P-452 and P-450j, may be induced by energy restriction. Such changes in cytochrome P-450 isozyme profiles could result in altered carcinogen activation, radical formation or drug detoxification in the energy-restricted rats.
KW - aging
KW - Drugs
KW - energy intake
KW - metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - medicines
KW - pharmaceuticals
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418911&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. 2. Effects on conjugating enzymes.
AU - Leakey, J. E. A.
AU - Cunny, H. C.
AU - Bazare, J., Jr.
AU - Webb, P. J.
AU - Lipscomb, J. C.
AU - Slikker, W., Jr.
AU - Feuers, R. J.
AU - Duffy, P. H.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 157
EP - 166
SN - 0047-6374
AD - Leakey, J. E. A.: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901418913. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition
N2 - The effects of long-term energy restriction on the hepatic phase II drug-metabolizing enzymes were investigated in male Fischer 344 rats. Rats that had been restricted to 60% of their pair-fed control's consumption from 14 weeks post partum exhibited altered conjugating enzyme activities at 22 months. Energy restriction significantly reduced the age-related decrease in glutathione S-transferase activity towards 1,2-dichloro-4-nitrobenzene, but did not significantly alter the age-related changes in UDPglucuronyltransferase or sulphotransferase activities towards hydroxysteroids. Energy restriction seemed to increase hepatic microsomal UDPglucuronyltransferase activity toward bilirubin and γ-glutamyl transpeptidase activities. These observations suggest that energy restriction has multiple effects on the hepatic phase II drug-metabolizing enzymes in rats. Such effects may alter hepatic metabolism and activation or detoxification of drugs and carcinogens.
KW - aging
KW - Drugs
KW - energy intake
KW - metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - medicines
KW - pharmaceuticals
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418913&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat.
AU - Feuers, R. J.
AU - Duffy, P. H.
AU - Leakey, J. A.
AU - Turturro, A.
AU - Mittelstaedt, R. A.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 179
EP - 189
SN - 0047-6374
AD - Feuers, R. J.: Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901418916. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition
N2 - It is well established that energy restriction extends life-span and significantly retards the rate of occurrence of most age-associated degenerative disease processes. A paucity of data exists relative to the mechanism by which energy restriction accomplishes these events. The effect of energy restriction in rats on several hepatic enzymes of intermediary metabolism was studied in rats. The activities of glycolytic and supporting enzymes including lactate dehydrogenase, pyruvate kinase, sorbitol dehydrogenase and alcohol dehydrogenase were all decreased in response to energy restriction. Fructose-1-phosphate aldolase and creatine phosphokinase were not altered. Likewise, enzymes associated with lipid metabolism (malic enzyme and glycerokinase) were reduced (fatty-acid synthase was reduced, but not to a statistically significant degree). Activities of enzymes supporting gluconeogenesis (aspartate aminotransferase, tyrosine aminotransferase, alanine aminotransferase, glutamate dehydrogenase, amino-acid oxidase, malate dehydrogenase and glucose-6-phosphatase) were either unchanged or increased significantly by energy restriction. Glucagon values were decreased. Comparisons between young freely fed and older energy-restricted rats revealed similar but not identical metabolic activity. The results suggest that energy restriction produces an effect on intermediary metabolism, favouring the role of glucagon and glucose synthesis, but limiting the role of insulin and glucose catabolism in the liver. The former observation provides for the efficient support of peripheral tissues and the latter a level of energy production necessary only for self-maintenance. Limited lipid metabolism suggests decreased potential for fatty acid epoxide formation and free radical damage to cellular macromolecules. Additionally, energy restriction may delay the progressive age-associated changes in the activities of some of the enzymes investigated.
KW - Energy intake
KW - metabolism
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418916&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of long-term caloric restriction on brain monoamines in aging male and female Fischer 344 rats.
AU - Kolta, M. G.
AU - Holson, R.
AU - Duffy, P.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 191
EP - 198
SN - 0047-6374
AD - Kolta, M. G.: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901418918. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - The changes in central monoamines and their metabolites after long-term energy restriction were studied in groups of 5 to 10 old Fischer 344 rats of both sexes on one of two dietary regimens: NIH 31 diet to appetite or 60% by weight of the free intake (restricted), supplemented with vitamins and minerals from 14 weeks old until killed at 22.25 months old. Caudate nucleus (CN), hypothalamus (HYPO), olfactory bulb (OB) and nucleus accumbens (NA) were assayed for content of norepinephrine (NE), dopamine (DA) and its metabolites (dihydroxyphenylacetic acid and homovanillic acid) and serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). Relative to the freely fed group, restricted rats of both sexes showed significant decreases in NE content in CN, HYPO and OB. DA and 5-HT contents were decreased significantly in the CN and HYPO. No significant changes were found in the concentrations of DA metabolites in all brain regions studied. While 5-HIAA was significantly reduced in the HYPO and NA of the female restricted rats, it was increased severalfold in the OB of the male restricted rats. These preliminary results suggest that long-term energy restriction alters brain monoamine concentrations, an effect which may in turn modify the normal rate of ageing.
KW - brain
KW - Energy intake
KW - monoamines
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418918&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effect of dietary restriction on myc protooncogene expression in mice: a preliminary study.
AU - Nakamura, K. D.
AU - Duffy, P. H.
AU - Lu, M. H.
AU - Turturro, A.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1989///
VL - 48
IS - 2
SP - 199
EP - 205
SN - 0047-6374
AD - Nakamura, K. D.: Department of Health and Human Services, Public Health Service, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901418920. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition
N2 - The effect of chronic dietary restriction on the expression of the c-myc protooncogene was determined in the liver of a hybrid mouse strain (C57B16 X C3H F1 hybrid) at 3 times during 24 h: 1 h after lights on (1 HALO), 5 h before feeding (12 HALO) and 2 h after feeding (19 HALO). In addition, in whole-animal studies, changes in core body temperature were monitored. In mice which had been subjected to chronic diet restriction (60% of the intake of freely fed controls), c-myc expression was significantly reduced at 1 HALO and 19 HALO compared with corresponding freely fed mice. Significant differences in c-myc expression were found between time points, in both the freely fed and restricted groups, suggesting that myc protooncogene expression in the liver may be regulated in a circadian fashion. C-myc expression may be correlated with body temperature, suggesting a possible association with metabolic output.
KW - carcinoma
KW - Energy intake
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418920&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of in vitro, animal, and clinical determinations of iron bioavailability: International Nutritional Anemia Consultative Group Task Force report on iron bioavailability.
AU - Forbes, A. L.
AU - Adams, C. E.
AU - Arnaud, M. J.
AU - Chichester, C. O.
AU - Cook, J. D.
AU - Harrison, B. N.
AU - Hurrell, R. F.
AU - Kahn, S. G.
AU - Morris, E. R.
AU - Tanner, J. T.
AU - Whittaker, P.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989///
VL - 49
IS - 2
SP - 225
EP - 238
SN - 0002-9165
AD - Forbes, A. L.: P. Whittaker, Food and Drug Administration, 200 C St SW (HFF-268), Washington, DC 20204, USA.
N1 - Accession Number: 19891414944. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Relative bioavailability of two iron supplements, electrolytic Fe and ferric orthophosphate, was related to that of the reference ferrous sulphate with a method in vitro and a rat model depletion-repletion method in 4 laboratories to compare values directly with those obtained in a parallel human study. Testing in vitro was performed on Fe compounds with solubility and dialysis in a simulated gastrointestinal digestion system. Two depletion-repletion techniques, haemoglobin-regeneration efficiency (HRE) and an official method of the Association of Official Analytical Chemists (AOAC), were examined. AOAC relative biological values (RBV) of electrolytic Fe were 0.66 and 0.78 and of FePO4 were 0.25 and 0.34. HRE values were 0.78 and 0.58 for electrolytic Fe and FePO4, respectively. When compared with FeSO4 in a radiolabelled farina-based meal given to adults, the RBV of FePO4 was 0.25 and electrolytic Fe 0.75. Results obtained with the AOAC method serve as the most reliable prediction of Fe bioavailability in man although dialysis in vitro is a promising screening technique.
KW - availability
KW - estimation
KW - Iron
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891414944&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An improved method for oxidation of chromium(III) oxide-containing fecal samples by using sodium peroxide fusion.
AU - Calvert, R. J.
AU - Kritchevsky, E. S.
AU - Einhorn, E.
AU - Klurfeld, D. M.
AU - Kritchevsky, D.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989///
VL - 49
IS - 5
SP - 901
EP - 903
SN - 0002-9165
AD - Calvert, R. J.: US Food and Drug Administration, Experimental Nutrition Branch, HFF-268, 200 "C" Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901417267. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 7440-47-3. Subject Subsets: Human Nutrition
N2 - A safer method of oxidation of faecal samples containing chromium oxide from transit-time studies was developed using sodium peroxide to replace perchloric acid as the oxidizing agent. The percentage recovery of Cr2O3 with this method was compared with that of a perchloric acid method for samples containing quantities of faecal ash and Cr2O3 typical of those from rodent transit-time studies. Both methods gave relatively constant percentage recoveries for Cr2O3 contents from 0.4 to 10 mg. Over this range, mean (± s.d.) percentage recoveries of Cr2O3 for sodium peroxide fusion and the perchloric acid method were 75.5 ± 4.3 and 89.9 ± 2.5, respectively. As long as percentage recovery is constant, the transit time as estimated by calculation of the time of 80% excretion of the total recovered Cr2O3 is not affected. Sodium peroxide fusion provides a useful and safer alternative to perchloric acid oxidation in transit-time studies using Cr2O3 as a non-absorbable marker.
KW - Chromium
KW - estimation
KW - faeces
KW - feces
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901417267&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Issues in reproducibility and validity of dietary studies.
AU - Block, G.
AU - Hartman, A. M.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989///
VL - 50
SP - 1133
EP - 1138
SN - 0002-9165
AD - Block, G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Executive Plaza North, Room 313, Bethesda, MD 20892, USA.
N1 - Accession Number: 19901418368. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - Numerous factors affect the reproducibility and validity of dietary assessment questionnaires. Although the respondents' abilities to respond accurately are most frequently discussed as the cause of apparently poor reproducibility and validity, many other factors are as important and perhaps more important. Most of these other factors are under the control of the investigator and thus are amenable to improvement. Factors which may affect reproducibility include the degree of variability permitted by the instrument, the error-proneness of the response format, quality control of coding and keying, and real dietary change in the time between the 2 administrations of the questionnaire. Factors affecting real or apparent validity include respondent characteristics, questionnaire design and quantification, quality control, and the adequacy of the reference data. The implications of inadequate reference data are illustrated and discussed.
KW - Diet study techniques
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901418368&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HACCP and filth in food. The detection and elimination of pest infestation.
AU - Gorham, J. R.
JO - Journal of Environmental Health
JF - Journal of Environmental Health
Y1 - 1989///
VL - 52
IS - 2
SP - 84
EP - 86
SN - 0022-0892
AD - Gorham, J. R.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St., Washington, DC 20204, USA.
N1 - Accession Number: 19900599252. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology; Agricultural Entomology
N2 - In the USA, the term 'filth' as understood in the retail/commercial enforcement of the federal Food, Drug and Cosmetic Act refers, in part, to rodent and arthropod pests that either infest food, come into contact with food or frequent surfaces used to prepare food. Many such pests not only mechanically transmit pathogens but some also cause allergies, produce toxins or are physically harmful. Adults of Tribolium spp. produce toxic quinones which contaminate flour and flour products. Field crops attacked by pests produce phytoalexins which may be incorporated into foods. Many arthropods, particularly storage mites and cockroaches, cause allergies in people who eat food which has come into contact with them. It has been reported that a baby developed ulcerative colitis after consuming cereal infested with larve of Trogoderma glabrum; the detachable larval hairs had penetrated the intestinal mucosa. Information is given on how hazards associated with filth in food can be avoided by purchasing only from reliable suppliers, inspecting all incoming items for contamination and rejecting any that are substandard, maintaining pest-free premises and strictly adhering to the Hazard Analysis Critical Control Point (HACCP) system of food sanitation. Methods of food preservation and sterilization are outlined with regard to reducing pathogen transmission.
KW - agricultural entomology
KW - Allergies
KW - arthropod allergies
KW - arthropod pests
KW - biodeterioration
KW - Contamination
KW - food
KW - Food hygiene
KW - Food inspection
KW - Foods
KW - health hazards
KW - legislation
KW - Storage mites
KW - stored products
KW - Stored products pests
KW - North America
KW - USA
KW - Acari
KW - arthropods
KW - Blattaria
KW - Coleoptera
KW - Dermestidae
KW - Diptera
KW - Formicidae
KW - Hymenoptera
KW - Man
KW - Mites
KW - Tenebrionidae
KW - Tribolium
KW - Trogoderma glabrum
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - Coleoptera
KW - Hymenoptera
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Acari
KW - Tenebrionidae
KW - Trogoderma
KW - Dermestidae
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Blattodea
KW - pest arthropods
KW - storage pests
KW - stored-product pests
KW - stored-products mites
KW - United States of America
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Laws and Regulations (DD500)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900599252&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Foodborne filth and human disease.
AU - Gorham, J. R.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1989///
VL - 52
IS - 9
SP - 674
EP - 677
SN - 0362-028X
AD - Gorham, J. R.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901358301. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - The problems and implications of foodborne filth (defined as extraneous matter derived from pests contaminating foods) are reviewed and discussed in relation to its significance inter alia in foodborne diseases.
KW - biodeterioration
KW - contaminants
KW - foodborne diseases
KW - Foods
KW - pathogens
KW - reviews
KW - Biodeterioration (SS300)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901358301&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative comparison of two enrichment methods for isolating Listeria monocytogenes from inoculated ice cream.
AU - Hitchins, A. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1989///
VL - 52
IS - 12
SP - 898
EP - 900
SN - 0362-028X
AD - Hitchins, A. D.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19900438603. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - Two enrichment methods for isolating Listeria monocytogenes (the Lovett method, formerly used by the FDA, and the revised method for the USDA) were compared using 25-g test portions of spiked vanilla ice cream. Both methods were found to be equally sensitive. Prolonging the enrichments to 7 days and the use of alkali pretreatment had no significant effect on the results. Reduction of the test portion size from 25 to 1 g in the revised USDA method decreased the level of sensitivity by an order of magnitude, as expected.
KW - biodeterioration
KW - Cows
KW - detection
KW - ice cream
KW - isolation
KW - pathogens
KW - Techniques
KW - cattle
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Storage Problems and Pests of Food (QQ111)
KW - Milk and Dairy Produce (QQ010)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900438603&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of four procedures to detect Listeria spp. in foods.
AU - Heisick, J. E.
AU - Harrell, F. M.
AU - Peterson, E. H.
AU - McLaughlin, S.
AU - Wagner, D. E.
AU - Wesley, I. V.
AU - Bryner, J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1989///
VL - 53
IS - 3
SP - 154
EP - 157
SN - 0362-028X
AD - Heisick, J. E.: Center for Microbiological Investigations, Food and Drug Administration, Minneapolis, MN 55401, USA.
N1 - Accession Number: 19900436793. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - A comparison was made of 4 procedures to detect Listeria spp. in 2 food categories. The study comprised 309 assays, 71 on milk from both infected and uninfected cows, and 238 on 10 types of fresh vegetables. A sample was considered positive if it could be detected by at least a single method and if isolates could be confirmed as Listeria spp. The procedures detected 98-100% of the positive milk samples. Recovery from vegetable samples ranged from 45 to 86%, probably because of low levels of Listeria spp. in the presence of mixed flora. The ELISA procedure of the Organon Teknika® corporation detected 68% of the 44 positive vegetable samples; the GENE-TRAK® DNA probe, 45%; the FDA culture procedure, 75%; and the FDA probe procedure, 86%. Recovery was higher with LiCl-phenylethanol-moxalactam agar (FDA probe procedure) than with modified McBride Agar (FDA culture procedure).
KW - biodeterioration
KW - Cows
KW - detection
KW - foods
KW - milk
KW - pathogens
KW - Techniques
KW - vegetables
KW - cattle
KW - Listeria
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - vegetable crops
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900436793&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative recovery of uninjured and heat-injured Listeria monocytogenes cells from bovine milk.
AU - Crawford, R. G.
AU - Beliveau, C. M.
AU - Peeler, J. T.
AU - Donnelly, C. W.
AU - Bunning, V. K.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1989///
VL - 55
IS - 6
SP - 1490
EP - 1494
SN - 0099-2240
AD - Crawford, R. G.: Division of Microbiology, Food and Drug Administration, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19900442152. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science; Public Health
N2 - The standard selective enrichment protocols of the FDA and USDA were compared with an experimental nonselective broth enrichment (NSB) protocol and variations of the standard cold-enrichment (CE) protocol for the recovery of heat-injured Listeria monocytogenes. Bacterial cells (107/ml) were suspended in sterile milk and heated at 71.7°C in a slug-flow heat exchanger for holding times ranging from 1 to 30 s. Surviving cells were determined (50% endpoint) by the given protocols, and the following D values were obtained: NSB, D = 2.0±0.5 s; FDA, D = 1.4±0.3 s; USDA, D = 0.6±0.2 s; CE, D≤1.2 s. The respective direct-plating media used in these enrichments were also analysed for recovery, and the following D values were calculated from the enumeration of surviving cells: NSB, D = 2.7±0.8 s; FDA, D = 1.3±0.4 s; USDA, D = 0.7±0.2 s. The low levels of heat-injured L. monocytogenes cells which were detected at inactivation endpoints on the optimal nonselective media (25°C for 7 days) failed to recover and multiply during experimental CE (4°C for 28 days). Initial inactivation experiments in which raw whole milk was used as the heating menstruum gave much lower recoveries with all protocols. The detectable limits for uninjured cells that were suspended in raw milk were similar (0.35 to 3.2 cells/ml) for the standard CE, FDA, and USDA protocols. Recovery by the NSB procedure (68 cells/ml) was compromised by background flora. The above data suggest that any cells surviving HTST pasteurization will be injured and unable to multiply either during cold storage of milk or in the FDA or USDA systems. Thus, L. monocytogenes cells recovered in finished pasteurized milk products by these detection methods probably represent uninjured environmental contaminants.<new para>ADDITIONAL ABSTRACT:<new para>The authors compare the efficiency of different methods for the recovery of uninjured and heat-injured Listeria monocytogenes from milk.Uninjured L. monocytogenes was isolated from artificially contaminated raw milk inoculated with 0.38-3.2 cells/ml in the presence of a background flora by the Food and Drug Administration (FDA), the US Department of Agriculture (USDA) and standard cold-enrichment methods.For heat-injury studies, L. monocytogenes was heated in sterile milk containing 107 cells/ml for 1-30 seconds. Survival was rare at 15 s and none was detected after longer heating times. Recovery was best in a non-selective medium (trypticase soy-yeast extract broth) incubated at 25 °C for 7 days followed by subculture to modified McBride agar. Poor recovery was obtained with the FDA, USDA and cold-enrichment methods. Inclusion of cells of L. monocytogenes in bovine phagocytes gave no added protection during heating.Recovery of heat-injured L. monocytogenes from raw milk containing background flora was poorer than in sterile milk and it was often difficult to detect the organism.The authors concluded that public health hazards from heat-injured L. monocytogenes were minimized by impaired ability to multiply in milk at 4 °C or in the standard methods used for isolation. L. monocytogenes organisms recovered from pasteurized milk by the FDA, USDA or cold-enrichment methods are likely to be post-pasteurization contaminants.[Recovery of heat-damaged L. monocytogenes from heated raw milk might be improved by subculture of enrichment media to Listeria selective agar (Oxoid formulation). This medium has been developed since the above study was made and is very selective for L. monocytogenes.]R.A.E. Barrell
KW - biodeterioration
KW - Cows
KW - culture media
KW - detection
KW - enrichment
KW - food
KW - isolation
KW - milk
KW - pathogens
KW - recovery
KW - Techniques
KW - bacteria
KW - cattle
KW - Listeria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Listeria
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Milk and Dairy Produce (QQ010)
KW - Microbial Technology in Food Processing (QQ120)
KW - Microbiology (General) (ZZ390)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900442152&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diagnostic methods and epidemiologic surveillance of Taenia solium infection.
AU - Schantz, P. M.
AU - Sarti-Gutierrez, E.
JO - Acta Leidensia
JF - Acta Leidensia
Y1 - 1989///
VL - 57
IS - 2
SP - 153
EP - 163
SN - 0065-1362
AD - Schantz, P. M.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920877801. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 54 ref. Subject Subsets: Helminthology
N2 - The status and limitations of diagnostic methods for surveillance of T. solium infection is reviewed under the headings: intestinal parasite surveys; surveillance of human cysticercosis; serological surveys; swine slaughterhouse statistics. The need for further research is emphasized.
KW - Developmental stages
KW - diagnosis
KW - epidemiology
KW - helminths
KW - Human diseases
KW - immunodiagnosis
KW - metacestodes
KW - neurocysticercosis
KW - parasites
KW - reviews
KW - Serological surveys
KW - Cestoda
KW - man
KW - Taenia solium
KW - Taeniidae
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Taenia
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - growth phase
KW - Neurocystcercosis
KW - parasitic worms
KW - pork tapeworm
KW - seroepidemiology
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920877801&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microgeographic variation in rDNA intergenic spacers of Anopheles gambiae in western Kenya.
AU - McLain, D. K.
AU - Collins, F. H.
AU - Brandling-Bennett, A. D.
AU - Were, J. B. O.
JO - Heredity
JF - Heredity
Y1 - 1989///
VL - 62
IS - 2
SP - 257
EP - 264
SN - 0018-067X
AD - McLain, D. K.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900597918. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology
N2 - The genetic population structure of A. gambiae in western Kenya was investigated by hybridizing a rapidly evolving rDNA intergenic spacer sequence to restriction endonuclease digests of genomic DNA extracted from single mosquitoes from 7 localities near Kisumu. Significantly different distributions of restriction fragment arrays were obtained from field sites less than 10 km apart, which suggests restricted gene flow and a subdivided population structure. Eight of 21 possible comparisons between pairs of populations yielded significant differences. An eastern Kenya coastal population did not share its restriction fragment arrays with any of the western populations, suggesting that isolation by distance can be complete on a relatively small geographic scale (700 km).
KW - DNA
KW - Gene flow
KW - genetic variation
KW - genetics
KW - Genomes
KW - Molecular genetics
KW - Population genetics
KW - Africa
KW - Kenya
KW - Anopheles gambiae
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - mosquitoes
KW - rDNA
KW - Reproductive isolation
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900597918&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition and public policy.
AU - McGinnis, J. M.
JO - Bulletin of the New York Academy of Medicine
JF - Bulletin of the New York Academy of Medicine
Y1 - 1989///
VL - 65
IS - 10
SP - 1164
EP - 1174
SN - 0028-7091
AD - McGinnis, J. M.: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC, USA.
N1 - Accession Number: 19901452527. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - The Surgeon General's Report on Nutrition and Health is a significant achievement, comprehensively reviewing scientific evidence that links diet to chronic disease, identifying consensus on the implications of the evidence for policy, and offering dietary recommendations developed on the basis of the policy consensus. Several of the Report's dietary and policy recommendations have implications for child health and nutrition. In addition to findings directly related to the dietary patterns of the USA, the Surgeon General's Report contains numerous recommendations for nutrition policy. Policy findings are grouped into several key categories: public education, nutrition labelling, professional education, removal of barriers, health care programmes, food products, food services, food assistance programmes, surveillance and research.
KW - Nutrition
KW - policy
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452527&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera.
AU - Calisher, C. H.
AU - Karabatsos, N.
AU - Dalrymple, J. M.
AU - Shope, R. E.
AU - Porterfield, J. S.
AU - Westaway, E. G.
AU - Brandt, W. E.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1989///
VL - 70
IS - 1
SP - 37
EP - 43
SN - 0022-1317
AD - Calisher, C. H.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19910504841. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - The recently established virus family Flaviviridae contains at least 68 recognized members. Sixty-six of these were tested by cross-neutralization in cell cultures. Flaviviruses were separated into 8 complexes containing 49 viruses: tick-borne encephalitis (12 viruses), Rio Bravo (6), Japanese encephalitis (10), Tyuleniy (3), Ntaya (5), Uganda S (4), dengue (4) and Modoc (5); 17 other viruses were not sufficiently related to warrant inclusion in any of these complexes.
KW - Antigens
KW - Arboviruses
KW - taxonomy
KW - Virology
KW - Acari
KW - Arachnida
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Japanese encephalitis virus
KW - Modoc virus
KW - Ntaya virus
KW - Rio Bravo virus
KW - Tick-borne encephalitis virus
KW - Tyuleniy virus
KW - Uganda S virus
KW - Viruses
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Diptera
KW - insects
KW - Hexapoda
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - arthropod-borne viruses
KW - Central European encephalitis virus
KW - immunogens
KW - mosquitoes
KW - serotaxonomy
KW - systematics
KW - Tickborne encephalitis virus
KW - Taxonomy and Evolution (ZZ380)
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic relatedness among structural protein genes of dengue 1 virus strains.
AU - Chu, M. C.
AU - O'Rourke, E. J.
AU - Trent, D. W.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1989///
VL - 70
IS - 7
SP - 1701
EP - 1712
SN - 0022-1317
AD - Chu, M. C.: Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19910504859. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
N2 - The structural protein-coding genomic regions of dengue virus type 1 (DEN-1) strains representing 3 distinct topotypes (Thailand, Philippines and Caribbean) were cloned and sequenced. In addition, the envelope (E) nucleotide sequences of 2 recent Caribbean topotype DEN-1 isolates were obtained by direct RNA sequencing. The nucleotide sequence of the DEN-1 viruses in the structural gene region was found to be highly conserved with >95% nucleotide sequence homology and with <4% change in the amino acid sequence. Although there was a <2% change in the nucleotide sequence of DEN-1 E proteins, strains could be differentiated by the clusters of nucleotide changes. Furthermore, the deduced amino changes in the E protein were clustered primarily within the proposed immunologically reactive regions. Genomic nucleotide sequence comparisons did not define geographical or virulence markers but located unique clusters of nucleotide/amino acid changes for each of the 3 topotypes of DEN-1 viruses examined.
KW - Amino acids
KW - Arboviruses
KW - Envelope proteins
KW - Genes
KW - Molecular genetics
KW - nucleotide sequences
KW - RNA
KW - Virology
KW - Aruba
KW - Asia
KW - Caribbean
KW - Jamaica
KW - Mexico
KW - Philippines
KW - Thailand
KW - Dengue virus
KW - Flaviviridae
KW - Flavivirus
KW - Viruses
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Kingdom of the Netherlands
KW - Lesser Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - ACP Countries
KW - Caribbean Community
KW - Commonwealth of Nations
KW - Greater Antilles
KW - Threshold Countries
KW - APEC countries
KW - Latin America
KW - North America
KW - OECD Countries
KW - ASEAN Countries
KW - South East Asia
KW - Asia
KW - arthropod-borne viruses
KW - biochemical genetics
KW - DNA sequences
KW - ribonucleic acid
KW - structural proteins
KW - West Indies
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504859&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of lead in canned evaporated milk.
AU - Capar, S. G.
AU - Rigsby, E. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1989///
VL - 72
IS - 3
SP - 416
EP - 417
SN - 1060-3271
AD - Capar, S. G.: US Food and Drug Administration, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19950503228. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - A US Food and Drug Administration (USFDA) survey of lead in canned evaporated milk conducted in fiscal year 1985-86 found a mean level of 0.006 µg Pb/g. This level is much lower than that found in previous surveys and is attributed to the use of nonlead-soldered cans for packaging evaporated milk.
KW - analytical methods
KW - canned products
KW - cans
KW - cows
KW - evaporated milk
KW - heavy metals
KW - lead
KW - soldering
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Residues and Contamination of Animal Products (SS120) (Discontinued March 2000)
KW - Human Nutrition (General) (VV100)
KW - Chemistry (ZZ600) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gamma-ray spectroscopic determination of iodine-131 and cesium-137 in foods: two collaborative studies.
AU - Baratta, E. J.
AU - Easterly, D. G.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1989///
VL - 72
IS - 4
SP - 667
EP - 669
AD - Baratta, E. J.: Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St, Winchester, MA 01890, USA.
N1 - Accession Number: 19910447058. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7440-46-2, 7553-56-2. Subject Subsets: Human Nutrition; Dairy Science
N2 - The AOAC method for iodine-131, caesium-137 and barium-140 in milk by gamma-ray spectroscopy (48.025-48.029) was extended to include other foods for the radionuclides iodine-131 and caesium-137. Two collaborative studies were performed to validate this extension. In the first study, a food sample containing 119 pCi 131I and 53 pCi 137Cs/kg was sent to each of 45 laboratories for triplicate analyses. For 25 responses, the mean of the reported values was 123.8 pCi/kg for iodine-131 and, for 27 responses, the mean was 53.4 pCi/kg for caesium-137. Repeatability (within laboratory) s.d. (sr) for iodine-131 and caesium-137 were 4.6 and 3.7 pCi/kg resp. Reproducibility (between laboratories) s.d. (sR) for iodine-131 and caesium-137 were 12.1 and 6.0 pCi/kg resp. In the second study, a food sample containing 25 pCi 131I and 27 pCi137Cs/kg was sent to each of 54 laboratories for triplicate analyses. For 21 responses, the mean of the reported values was 25.0 pCi/kg for iodine-131 and, for 19 responses, the mean was 28.9 pCi/kg for caesium-137. sr values were 4.0 and 1.6 pCi/kg for iodine-131 and caesium-137 resp., and sR values were 5.0 and 2.8 pCi/kg resp. The method extension was adopted official first action. Food samples included milk and milk products.
KW - Caesium
KW - Cows
KW - foods
KW - gamma spectrometry
KW - Iodine
KW - milk
KW - milk products
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 131I
KW - 137Cs
KW - cesium
KW - dairy products
KW - gamma spectroscopy
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910447058&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethyl carbamate levels in selected fermented foods and beverages.
AU - Canas, B. J.
AU - Havery, D. C.
AU - Robinson, L. R.
AU - Sullivan, M. P.
AU - Joe, F. L., Jr.
AU - Diachenko, G. W.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1989///
VL - 72
IS - 6
SP - 873
EP - 876
AD - Canas, B. J.: Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19900441248. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 51-79-6. Subject Subsets: Dairy Science; Soyabeans; Human Nutrition
N2 - Ethyl carbamate (EC), also known as urethane, is an animal carcinogen and a byproduct of fermentation. Because EC has been found in distilled spirits and wines, a variety of fermented foods and beverages was analysed to assess its occurrence in other products. Previously described methods using a gas chromatograph-thermal energy analyser with a nitrogen converter were modified for each matrix and gave recoveries of >80%, with a limit of detection in the 1-2 µg/kg (parts per 109) (p.p.b.) range. A total of 152 test samples was analysed; EC levels ranged from none found to 3 p.p.b. in 15 cheeses, 6 teas, 12 yoghurts and 8 ciders; from none found to 13 p.p.b. in 30 breads and 69 malt beverages; and from none found to 84 p.p.b. in 12 soya sauces. GC/MS/MS was used to confirm EC identity and to quantify EC in selected food extracts.
KW - Beverages
KW - Cheeses
KW - Cows
KW - cultured products
KW - determination
KW - Drugs
KW - estimation
KW - Foods
KW - Soya sauce
KW - urethane
KW - Yoghurt
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - drinks
KW - ethyl carbamate
KW - ethylurethane
KW - joghurt
KW - medicines
KW - pharmaceuticals
KW - soy sauce
KW - yogurt
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900441248&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic-atomic absorption spectrophotometric method for determination of methyl mercury in seafood: collaborative study.
AU - Holak, W.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1989///
VL - 72
IS - 6
SP - 926
EP - 930
AD - Holak, W.: Food and Drug Administration, New York Regional Laboratory, 850 Third Ave., Brooklyn, NY 11232, USA.
N1 - Accession Number: 19911437806. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7439-97-6. Subject Subsets: Human Nutrition
KW - estimation
KW - mercury
KW - Seafoods
KW - Aquatic Produce (QQ060)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911437806&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enzyme-linked immunosorbent assay of aflatoxins B1, B2, and G1 in corn, cottonseed, peanuts, peanut butter, and poultry feed: collaborative study.
AU - Trucksess, M. W.
AU - Stack, M. E.
AU - Nesheim, S.
AU - Park, D. L.
AU - Pohland, A. E.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1989///
VL - 72
IS - 6
SP - 957
EP - 962
AD - Trucksess, M. W.: Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901206864. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition; Human Nutrition; Postharvest Research; Maize
N2 - A direct competitive ELISA screening method for aflatoxins at 20 ng/g was studied by 12 collaborators. Test samples of groundnut butter were extracted by blending with methanol-water-hexane (55+45+100) and heating the test extracts on a steam bath; test samples of the other commodities were extracted by blending with methanol-water (80+20). All test extracts were filtered and the filtrates were diluted with buffer to a final methanol concn of <30%. Each diluted filtrate was applied to a cup containing a filter with immobilized polyclonal antibodies specific to aflatoxins B1, B2 and G1. Aflatoxin B1-peroxidase conjugate was added, the cup was washed with water and a mixture of hydrogen peroxide and tetramethylbenzidine was added. The test sample was judged to contain ≥20 ng/g aflatoxins when, after exactly 1 min, no colour was observed on the filter; when a blue or grey colour developed, the test sample was judged to contain <20 ng/g aflatoxins. All collaborators correctly identified naturally contaminated maize and raw groundnut positive test samples. No false positives were found for controls containing <2 ng/g aflatoxins. The correct responses for positive test samples spiked at levels of 10, 20 and ≥30 ng/g aflatoxins (the ratio of B1:B2:G1 was 10:1:3) were 52, 86 and 96%, respectively. The method, which is rapid and simple, was adopted official first action for screening for aflatoxins at ≥20 ng/g in cottonseed and groundnut butter and for aflatoxins at ≥30 ng/g in maize and raw groundnuts. It is noted that the procedure required further study for poultry feed and that positive test samples may require reanalysis by an official quantitative method.
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - cottonseed
KW - detection
KW - determination
KW - ELISA
KW - estimation
KW - feeds
KW - groundnut butter
KW - groundnuts
KW - maize
KW - Mycotoxins
KW - poultry
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - corn
KW - domesticated birds
KW - enzyme linked immunosorbent assay
KW - feeding stuffs
KW - fungal toxins
KW - peanut butter
KW - peanuts
KW - Other Produce (QQ070)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206864&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic-electrochemical determination of ethylenethiourea in foods by revised official method.
AU - Krause, R. T.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1989///
VL - 72
IS - 6
SP - 975
EP - 979
AD - Krause, R. T.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19911437807. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
KW - estimation
KW - foods
KW - Fungicides
KW - residues
KW - fungistats
KW - Pesticides and Drugs (General) (HH400)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911437807&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The regulation of food additives in animal feeds.
AU - Waltz, D. M.
AU - Knight, W. M.
AU - Graber, G.
T2 - Journal of Dairy Science
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 1989///
VL - 72
IS - Suppl. 1
SP - 2
EP - 2
SN - 0022-0302
AD - Waltz, D. M.: Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19900436685. Language: English. Subject Subsets: Dairy Science; Animal Nutrition
N2 - Procedures for establishing an Investigational Food Additive Application and for filing a Food Additive Petition are discussed.
KW - Cows
KW - Feed additives
KW - regulations
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - rules
KW - United States of America
KW - Feed Additives (RR130)
KW - Laws and Regulations (DD500)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900436685&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Uganda I/CDC strain of Plasmodium malariae in Saimiri sciureus boliviensis.
AU - Collins, W. E.
AU - Skinner, J. C.
AU - Broderson, J. R.
AU - Richardson, B. B.
AU - Stanfill, P. S.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1989///
VL - 75
IS - 2
SP - 310
EP - 313
SN - 0022-3395
AD - Collins, W. E.: Div. Parasitic Diseases, Center for Infectious Diseases, CDC, Public Health Service, US Dep. Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19890858336. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2 - The Uganda I/CDC strain of P. malariae, initially adapted to monkeys of the genus Aotus, was studied in splenectomized S. sciureus boliviensis. Mean maximum parasitaemia ranged from 248 to 22 134/mm³. Only 1 of 2238 Anopheles freeborni became infected when fed during periods of high parasitaemia. After the parasite was adapted to this host, infections were characterized by periods of detectable parasitaemia extending up to 269 days and by sustained periods when parasite counts were greater than 1000/mm³. After 4 linear passages, the developmental time required before the primary peak parasite count was approximately 2 months.<new para>ADDITIONAL ABSTRACT:<new para>The Uganda I/CDC strain of Plasmodium malariae, initially adapted to monkeys of the genus Aotus, was studied in splenectomized Saimiri sciureus boliviensis. Mean maximum parasitemia ranged from 248 to 22 134/mm³. Only 1 mosquito was infected of 2238 examined. After the parasite was adapted to this host, infections were characterized by periods of detectable parasitemia extending up to 269 days and by sustained periods when parasite counts were greater than 1000/mm³. After 4 linear passages, the developmental time required before the primary peak parasite count was approximately 2 mo.AS
KW - animal models
KW - disease vectors
KW - experimental infection
KW - Human diseases
KW - infectivity
KW - Intermediate hosts
KW - Laboratory animals
KW - malaria
KW - parasites
KW - splenectomy
KW - Vectors
KW - Africa
KW - Uganda
KW - Anopheles freeborni
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - monkeys
KW - Plasmodium malariae
KW - Primates
KW - protozoa
KW - Saimiri boliviensis
KW - Saimiri sciureus
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Saimiri
KW - Cebidae
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - experimental transmission
KW - mosquitoes
KW - Saimiri sciureus boliviensis
KW - secondary hosts
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19890858336&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ultrastructural localization of phenoloxidase in the midgut of refractory Anopheles gambiae and association of the enzyme with encapsulated Plasmodium cynomolgi.
AU - Paskewitz, S. M.
AU - Brown, M. R.
AU - Collins, F. H.
AU - Lea, A. O.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1989///
VL - 75
IS - 4
SP - 594
EP - 600
SN - 0022-3395
AD - Paskewitz, S. M.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Services, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900862315. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2 - A melanogenic enzyme, phenoloxidase, was localized ultrastructurally in the midgut epithelia of 2 strains of A. gambiae, a refractory strain that melanotically encapsulates P. cynomolgi ookinetes on the midgut, and a susceptible strain that does not. Midguts were incubated with either dopa or dopamine, and the resultant electron-dense product of phenoloxidase activity was localized on the basal lamina (BL) and cellular basal membrane labyrinth (BML) in uninfected mosquitoes of both strains. In infected refractory mosquitoes, the reaction products still were observed on the BL and BML but were especially dense in the BML of midgut cells near encapsulated ookinetes and in the capsule itself. In infected susceptible mosquitoes, phenoloxidase localization was reduced or absent in the BL and BML and was not observed near parasites. Phenylthiourea (PTU) inhibited the phenoloxidase reaction, indicating that the reaction product deposited in the absence of PTU resulted from enzyme activity and not autooxidation of the substrates. It is concluded that higher levels of phenoloxidase in the refractory strain following a blood-meal may contribute to the ability to encapsulate ookinetes.
KW - disease vectors
KW - Enzymes
KW - Human diseases
KW - immune system
KW - infections
KW - midgut
KW - ookinetes
KW - parasites
KW - physiology
KW - susceptibility
KW - Vectors
KW - Anopheles gambiae
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - Insects
KW - Plasmodium
KW - Plasmodium cynomolgi
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Anopheles gambiae midgut
KW - mosquitoes
KW - phenoloxidase
KW - Refractoriness
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900862315&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malaria in migrants and travellers.
AU - Schultz, M. G.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1989///
VL - 83
IS - Suppl.
SP - 31
EP - 34
SN - 0035-9203
AD - Schultz, M. G.: Global EIS Division, International Health Program Office, Centers for Disease Control, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900864757. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Current literature on the epidemiology of malaria in migrants and travellers is reviewed briefly under the headings: effect of migration on malaria; effect of travel on malaria; vectors as migrants.
KW - disease vectors
KW - epidemiology
KW - Human diseases
KW - migration
KW - Mosquito-borne diseases
KW - parasites
KW - Reviews
KW - travel
KW - travel medicine
KW - Vectors
KW - Anopheles
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - man
KW - Plasmodium
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - 3rd International Congress on Malaria and Babesiosis
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Tourism and Travel (UU700)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864757&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional elements in US diets: results from the Total Diet Study, 1982 to 1986.
AU - Pennington, J. A. T.
AU - Young, B. E.
AU - Wilson, D. B.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1989///
VL - 89
IS - 5
SP - 659
EP - 664
SN - 0002-8223
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19921441010. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 7440-70-2, 7440-50-8, 7553-56-2, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6. Subject Subsets: Human Nutrition
N2 - Through the Food and Drug Administration's Total Diet Study, contents of sodium, potassium, calcium, phosphorus, magnesium, iron, zinc, copper, manganese, selenium and iodine in the diets of 8 age-sex groups were estimated between 1982 and 1986. The 234 Total Diet Study foods, which are representative of the USA food supply, were purchased, prepared for consumption, and analysed for the elements 4 times each year. The results were combined with national food consumption data to estimate intakes for infants 6 to 11 months old, children 2 years old, boys and girls 14 to 16 years old, men and women 25 to 30 and 60 to 64 years old. Ca, Mg, Fe, Zn, Cu and Mn were less than 80% of the Recommended Dietary Allowance or below the low end of the Estimated Safe and Adequate Daily Dietary Intake range for 3 or more of the age-sex groups. Six elements were of concern for teenage girls and adult women, 5 for older women, 3 for children 2 years old, 2 for teenage boys and older men, and one for infants and adult men. Na (which did not include discretionary salt) was increased at 2 years old and for teenage boys, and iodine was increased for all age-sex groups. A significant trend was noted for iodine, where intake decreased during the 4-year period. The decline in iodine was mainly due to the decreased iodine content of ready-to-eat breakfast cereals. That decrease may have been caused by a decline in the use of the red dye erythrosine by cereal manufacturers.
KW - Calcium
KW - Copper
KW - intake
KW - Iodine
KW - Iron
KW - Magnesium
KW - Manganese
KW - Minerals
KW - Phosphorus
KW - Potassium
KW - Selenium
KW - Sodium
KW - Zinc
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mn
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921441010&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of meal distribution of wheat bran on fecal bulk, gastrointestinal transit time and colonic thymidine kinase activity in the rat.
AU - Otsuka, M.
AU - Satchithanandam, S.
AU - Calvert, R. J.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1989///
VL - 119
IS - 4
SP - 566
EP - 572
SN - 0022-3166
AD - Otsuka, M.: R.J. Calvert, US Food and Drug Administration, Experimental Nutrition Branch, HFF-268, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19891415586. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts
N2 - Male Fischer 344 rats were fed for 6 weeks on fibre-free (FF), continuous 10% wheat bran (CWB) or intermittent 50% wheat bran (IWB) diets to investigate possible alterations in physiological effects associated with colon cancer (faecal bulk, transit time, colonic cell proliferation) induced by meal distribution of the bran. The FF and CWB groups consumed unvaried diets throughout the day. The IWB group consumed 2 consecutive meals of a 50% bran diet for 4 h each day followed by a fibre-free diet for the remaining hours of the day. Similar daily quantities of bran were eaten in the CWB and IWB groups. Dry faecal weights increased significantly and transit times declined in both bran-fed groups independent of the meal distribution of bran. Colonic cell proliferation (estimated by thymidine kinase activity) was similar in all groups. The results suggest that these physiological effects of wheat bran are independent of the meal distribution of the bran.
KW - colon
KW - wheat
KW - Wheat bran
KW - rats
KW - Triticum
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - function
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891415586&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prolonged acetaminophen ingestion in mice: effects on the availability of methionine for metabolic functions.
AU - Reicks, M.
AU - Hathcock, J. N.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1989///
VL - 119
IS - 7
SP - 1042
EP - 1049
SN - 0022-3166
AD - Reicks, M.: Division of Nutrition, HFF-268, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19891416024. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 103-90-2, 63-68-3. Subject Subsets: Human Nutrition
N2 - Acetaminophen (ACAP) was given to weanling mice at 0.0, 0.3, 0.5 or 0.8% of the diet, with methionine provided at requirement (0.5%) or at twice the requirement (1.0%) amount, for 2 weeks to assess its effect on the availability of methionine for growth. In another study, ACAP was given to adult mice at 0.0, 0.4, or 0.6% of the diet, with methionine at 0.5 or 1.0% of the diet, for 2 weeks to assess its effect on the availability of methionine for protein synthesis and methylation reactions. The growth rate of weanling mice decreased with increasing dietary ACAP in mice given 0.5% methionine, but not in those fed on 1.0%. Hepatic reduced glutathione (GSH) decreased and plasma alanine aminotransaminase activity incrased in an ACAP dose-dependent manner in weanling mice fed on 0.5% methionine. Protein-synthesizing ability decreased in adult mice given 0.5% methionine and 0.6% ACAP. Relative liver weight and liver lipid decreased with increasing dietary ACAP in mice fed on methionine at or above requirement. Neither plasma creatinine or muscle creatine was affected by variations in dietary methionine or ACAP. Ingestion of ACAP for a prolonged period of time increased the methionine requirement for growth, maintenance of hepatic GSH value and protein synthesis, but did not affect the methionine requirement for methylation reactions.
KW - Acetaminophen
KW - availability
KW - methionine
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - paracetamol
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19891416024&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumption of raw potato starch alters intestinal function and colonic cell proliferation in the rat.
AU - Calvert, R. J.
AU - Otsuka, M.
AU - Satchithanandam, S.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1989///
VL - 119
IS - 11
SP - 1610
EP - 1616
SN - 0022-3166
AD - Calvert, R. J.: US Food and Drug Administration, Experimental Nutrition Branch, Washington, DC 20204, USA.
N1 - Accession Number: 19901450013. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 977000-07-9, 9002-06-6. Subject Subsets: Human Nutrition; Potatoes
N2 - Raw potato starch (RPS) may escape complete digestion to enter the colon and produce alterations in colonic function, while cooked potato starch (CPS) is nearly completely digested in the rat small intestine. Effects of RPS and CPS on colonic function [faecal weight, transit time and thymidine kinase (TK) activity (a marker for cell proliferation)] were contrasted in a 6-week feeding study. Male F344 rats ate glucose/sucrose (GS; control), 30% CPS or 30% RPS diet. RPS feeding resulted in a 3-fold increase in faecal weight and a 30% prolongation in transit time, as well as increased values of colonic mucosal total protein (50%) and TK activity (4- to 7-fold) compared with GS-fed rats. A second study revealed normal large intestinal histology in rats given CPS or RPS, with elongated colonic crypts (33% increased over CPS) in group RPS. Large intestinal contents were heavier in group RPS than in group CPS. The results demonstrate that RPS feeding significantly increases faecal weight yet prolongs total gastrointestinal transit time. Enhanced colonic TK and elongated colonic crypts suggest that RPS stimulates colonic mucosal growth.
KW - Colon
KW - Nutrition
KW - potato starch
KW - thymidine kinase
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450013&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High nutrient intakes - the toxicologist's view.
AU - Hathcock, J. N.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1989///
VL - 119
IS - 12S
SP - 1779
EP - 1784
SN - 0022-3166
AD - Hathcock, J. N.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901419411. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - At sufficiently high intake all substances, including essential nutrients, can be toxic. Toxicity may be described by characteristics of the symptoms (identity, severity and degree of persistence) and by the dose-response relation (threshold, slope, limit, susceptibility to modulation by other substances and tendency to bioaccumulate). Some nutrient toxicities are deleterious exaggerations of essential functions, whereas others are not. The therapeutic indices for nutrients should be defined as the ratio of the lowest toxic dose to the recommended intake, the ratio of the medians of the effective and the toxic doses commonly used in pharmacology. For infant formulas, a ratio of the lowest toxic concentration to the maximum concentration allowed is an analogous ratio. Nutrients with low therapeutic indices and small physical size of a toxic dose require special caution to avoid excessive intake. Modulation of absorption, metabolism or excretion, as well as the physiological state of the exposed individual, may alter the minimum toxic intake of a nutrient and hence alter the risk of toxicity. Extrapolation to estimate the toxic dose can be made on the basis of body weight, body surface area or food intake. Nutrient minima and maxima in infant formula are set on a 100-kcal basis and thus are related to heat loss and surface area. Evaluation of vitamin A toxicity cases on a dose per 100-kcal basis suggest that the current maximum in infant formula is appropriate. Extrapolation from toxicity data in adults can be made on the dose per 100-kcal basis to estimate appropriate infant formula maxima for nutrients for which maxima have not been set.
KW - Infant foods
KW - Infant formulae
KW - nutrients
KW - nutritive value
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - baby foods
KW - infant formula
KW - infant formulas
KW - nutritional value
KW - quality for nutrition
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aerosolized pentamidine. Approved for HIV-infected individuals at high risk for Pneumocystis carinii pneumonia.
AU - Young, F. E.
AU - Nightingale, S. L.
AU - Cooper, E. C.
AU - Trapnell, C. B.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 1989///
VL - 149
IS - 11
SP - 2412
EP - 2413
SN - 0003-9926
AD - Young, F. E.: Associate Commissioner for Health Affairs, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19900864246. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology
N2 - This article describes the development of the use of aerosolized pentamidine for prophylaxis of P. carinii pneumonia and gives information regarding its use, safety precautions and use of the nebulizer.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - adverse effects
KW - aerosols
KW - Antiprotozoal agents
KW - Health care workers
KW - Human diseases
KW - Immunocompromised hosts
KW - Opportunistic infections
KW - parasites
KW - pentamidine
KW - Pneumocystis carinii pneumonia
KW - prophylaxis
KW - Toxicity
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - invertebrates
KW - adverse reactions
KW - AIDS
KW - fungus
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Health Services (UU350)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of gestational diabetes in a Navajo Indian community.
AU - Sugarman, J. R.
JO - Western Journal of Medicine
JF - Western Journal of Medicine
Y1 - 1989///
VL - 150
IS - 5
SP - 548
EP - 551
SN - 0093-0415
AD - Sugarman, J. R.: Shiprock Public Health Service Hospital, PO Box 160, Shiprock, NM 87420, USA.
N1 - Accession Number: 19911438659. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - A retrospective analysis of 4094 deliveries among Navàjo Indian women in north western New Mexico was made to determine the prevalence of gestational diabetes mellitus and diabetes antedating pregnancy. Three data sources, a local prenatal registry, a delivery room log and hospital discharge records, were evaluated for their usefulness as surveillance systems for gestational diabetes. In all 177 cases of gestational diabetes and 13 cases of pre-existing diabetes were identified, giving a prevalence of maternal diabetes in pregnancy of 4.6%. When women with pre-existing diabetes or documented gestational diabetes during a previous pregnancy were excluded, the prevalence of gestational diabetes during the study period was 3.4%. Although each data source used separately failed to identify 20 to 40% of diabetic pregnancies, more than 97% of cases were identified using a combination of the prenatal registry and the delivery log.
KW - diabetes
KW - Ethnic groups
KW - pregnancy
KW - New Mexico
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - gestation
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Echinococcosis (hydatid disease).
AU - Bryan, R. T.
AU - Schantz, P. M.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1989///
VL - 195
IS - 9
SP - 1214
EP - 1217
SN - 0003-1488
AD - Bryan, R. T.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333 USA.
N1 - Accession Number: 19930803098. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Helminthology
N2 - A general account of hydatid disease is given in the form of questions and answers. The questions were asked of a veterinarian by the parents of a 9-year-old boy from Kentucky, USA. He had become infected with Echinococcus granulosus during a 3-month visit to Italy. The child underwent 2 surgical procedures to remove a 4 cm cyst of the lung and a 5 cm cyst in his liver, and was well at 6 months follow-up.
KW - Case reports
KW - Children
KW - Developmental stages
KW - echinococcosis
KW - helminths
KW - Human diseases
KW - Imported infections
KW - metacestodes
KW - parasites
KW - Europe
KW - Italy
KW - Kentucky
KW - North America
KW - USA
KW - Cestoda
KW - Echinococcus granulosus
KW - man
KW - Taeniidae
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Echinococcus
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - North America
KW - America
KW - East South Central States of USA
KW - general account
KW - growth phase
KW - hydatid disease
KW - hydatidosis
KW - parasitic worms
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue procedures for the determination of chlorinated dibenzodioxins and dibenzofurans in a variety of foods using capillary gas chromatography-electron-capture detection.
AU - Jasinski, J. S.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1989///
VL - 478
IS - 2
SP - 349
EP - 367
SN - 0021-9673
AD - Jasinski, J. S.: US Department of Health and Human Services, Food and Drug Administration (Detroit District), 1560 E. Jefferson Avenue, Detroit, MI 48207, USA.
N1 - Accession Number: 19901417374. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition; Postharvest Research
N2 - Multiresidue digestion-extraction procedures for the estimation of chlorinated dioxins and furans in a wide variety of products are presented. Procedure selection is dependent on the residue(s) of interest, and on the fat content of the product. Additional clean-up is accomplished using column chromatography and a Florisil trap. The separation of residues is achieved by fraction collection off 2 high-performance liquid chromatographic systems. Capillary gas chromatography employing electron-capture detection is used for quantitation. The extracts are suitable for gas chromatography-mass spectrometry or gas chromatography with Hall electrolytic conductivity detection. Results of analysis, recovery data and interlaboratory comparisons are given. Spike recoveries are typically on average 90 ± 10%.<new para>ADDITIONAL ABSTRACT:<new para>The method described can be used for a wide variety of foods. The exact procedure varies according to the residue(s) being determined and the fat content of the food. The procedure for honey and other carbohydrates is given. In various foods spiked with 2,3,7,8-tetrachlorodibenzo-p-dioxin, recovery averaged 90±10%; for honey it was 106%. Results are given for the presence of 6 residues in two samples of "honey skimmings": 3 of the residues were not detected, and the others were found at 24-392 parts per trillion (1012).
KW - Analytical methods
KW - dibenzofurans
KW - estimation
KW - foods
KW - Honey
KW - impurities
KW - Pesticide residues
KW - analytical techniques
KW - dibenzodioxins
KW - Other Produce (QQ070)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Structural features of Borrelia burgdorferi - the Lyme disease spirochete: silver staining for nucleic acids.
AU - Garon, C. F.
AU - Dorward, D. W.
AU - Corwin, M. D.
JO - Scanning Microscopy
JF - Scanning Microscopy
Y1 - 1989///
SP - 109
EP - 115
SN - 0891-7035
AD - Garon, C. F.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19910503520. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology
N2 - Borrelia burgdorferi was grown in a modified Kelly medium and characterized by transmission and scanning electron microscopy. Using silver staining procedures which preferentially bind to nuclear components of eukaryotic cells, signal could be detected by back-scattered electron imaging throughout the length of the spirochaete. Interestingly, however, the highest levels of back-scattered signal were observed in naturally elaborated membrane blebs that were attached to cell surfaces and free in the medium. These membranes vesicles could be enriched by filtration through nitrocellulose or Anopore membranes and by differential centrifugation. The possibility of contaminating cellular DNA coating the membrane vesicles was ruled out by exhaustive digestion with pancreatic DNAase I. Intact DNA was demonstrated both by lysing blebs directly on the surface of microscope grids and by extracting molecules from purified bleb preparation with detergents and solvents. Both linear and circular DNA molecules could be identified in purified membrane blebs. A simple, one-step, alternative silver staining procedure is described which appears to effectively label the protein-nucleic acid complexes contained in the membrane vesicles of B. burgdorferi.
KW - DNA
KW - electron microscopy
KW - Scanning electron microscopy
KW - staining
KW - Borrelia burgdorferi
KW - Spirochaetaceae
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - deoxyribonucleic acid
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Long term dietary effects of soy protein in Cebus monkeys.
AU - Harwood, J. P.
AU - Jackson, B. A.
AU - McCabe, N.
A2 - Huisman, J.
A2 - Poel, T.F.B. van der
A2 - Liener, I.E.
T2 - Recent advances of research in antinutritional factors in legume seeds. Proceedings of the First International Workshop on "Antinutritional Factors (ANF) in Legume Seeds", November 23-25, 1988, Wageningen, Netherlands.
JO - Recent advances of research in antinutritional factors in legume seeds. Proceedings of the First International Workshop on "Antinutritional Factors (ANF) in Legume Seeds", November 23-25, 1988, Wageningen, Netherlands.
JF - Recent advances of research in antinutritional factors in legume seeds. Proceedings of the First International Workshop on "Antinutritional Factors (ANF) in Legume Seeds", November 23-25, 1988, Wageningen, Netherlands.
Y1 - 1989///
SP - 95
EP - 98
CY - Wageningen; Netherlands
PB - Centre for Agricultural Publishing and Documentation (PUDOC)
SN - 902200979
AD - Harwood, J. P.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911453779. Publication Type: Conference paper. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Soyabeans
N2 - The study was made to evaluate whether prolonged exposure of primates to diets containing soyabean trypsin inhibitor has any adverse nutritional impact. A total of 26 Cebus monkeys were given from infancy semisynthetic diets containing, as their only source of protein, casein, lactalbumin, soyabean isolate or soyabean concentrate. Each batch of 4 diets was tested for trypsin inhibitor content. After 3 years pancreatic biopsy was made. There was no evidence of pancreatic hypertrophy or hyperplasia. After 5 years of continuous exposure to the diet a full autopsy was made together with haematology and blood chemistry. Examination of the organs and tissues showed no adverse pathology related to ingestion of trypsin inhibitor. Overall health, body weight and blood values were similar among groups.
KW - antinutritional factors
KW - Soyabean products
KW - Soyabeans
KW - Netherlands
KW - Glycine (Fabaceae)
KW - primates
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - Antinutritional factors in legume seeds
KW - soybean products
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Human ehrlichiosis in the United States.
AU - Fishbein, D. B.
A2 - Williams, J.C
A2 - Kakoma, I.
T2 - Ehrlichiosis: a vector-borne disease of animals and humans.
JO - Ehrlichiosis: a vector-borne disease of animals and humans.
JF - Ehrlichiosis: a vector-borne disease of animals and humans.
Y1 - 1989///
SP - 100
EP - 111
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0792306910
AD - Fishbein, D. B.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, United States Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19940502267. Publication Type: Miscellaneous. Language: English. Number of References: 24 ref.
N2 - In 1986, a 51-year-old man hospitalized with an illness clinically resembling "spotless" Rocky Mountain spotted fever was shown to have ehrlichiosis. Subsequently, 100 additional cases among patients in 15 states of the USA have been identified by various investigators. Most patients had a recent tick exposure, and acute febrile illness with nonspecific symptoms and mild degrees of liver dysfunction, leukopenia, and thrombocytopenia. Intraleukocytic inclusions have been found in only 3 cases. Active surveillance in hospitalized patients in Georgia, USA revealed a rate of 5.3 per 100 000 population. Cases differed from the noncases in that they were more likely to report a recent tick bite (P<0.02) and reside in a rural county (P<0.02). Cases also had lower white blood cell counts (P<0.001), platelet counts (P=0.01), and higher asparate aminotransferase (P<0.005) and alanine aminotransferase (P<0.01) levels at the time of admission to the hospital. Ehrlichiosis is an important cause of acute febrile illness in some parts of the USA, and is distinguishable from other febrile illnesses, primarily by history of tick bite and the presence of abnormal haematology and liver function test results. The putative etiologic agent has not been isolated, but is considered to be closely related to E. canis. The possibility of the zoonotic nature of ehrlichiosis is discussed but remains largely speculative and epidemiologically unsubstantiated. The differential diagnosis of ehrlichiosis-like disease and Rocky Mountain spotted fever (without a rash) is discussed and criteria for ehrlichiosis case definition are suggested.
KW - diagnosis
KW - disease vectors
KW - human diseases
KW - rickettsial diseases
KW - tickborne diseases
KW - zoonoses
KW - USA
KW - Acari
KW - Ehrlichia
KW - Ehrlichia canis
KW - Ixodidae
KW - man
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ehrlichia
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Listeria monocytogenes.
AU - Lovett, J.
A2 - Doyle, M. P.
T2 - Foodborne bacterial pathogens.
Y1 - 1989///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824778669
AD - Lovett, J.: U.S. Food and Drug Administration, Cincinnati, Ohio, USA.
N1 - Accession Number: 19900441117. Publication Type: Book chapter. Language: English. Number of References: 124 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Dairy Science
N2 - This chapter is sub-divided under the following main headings: Introduction; Characterization of the organism; Characteristics of the disease; Epidemiology; Isolation and identification; Mechanisms of pathogenicity; Control measures. Foods of animal origin are an important source of Listeria monocytogenes in humans; the foods mentioned include poultry, meat, milk, soft cheese, ice cream, cottage cheese and other milk products.
KW - cheeses
KW - Cottage cheese
KW - Cows
KW - food poisoning
KW - Foods
KW - ice cream
KW - meat
KW - milk
KW - milk products
KW - pathogens
KW - poultry
KW - Soft cheese
KW - cattle
KW - Listeria
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - dairy products
KW - domesticated birds
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Aeromonas hydrophila.
AU - Stelma, G. N., Jr.
A2 - Doyle, M. P.
T2 - Foodborne bacterial pathogens.
Y1 - 1989///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824778669
AD - Stelma, G. N., Jr.: U.S. Food and Drug Administration, Cincinnati, Ohio, USA.
N1 - Accession Number: 19900441111. Publication Type: Book chapter. Language: English. Number of References: 99 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Dairy Science
N2 - Although the reported cases of food-poisoning in which Aeromonas hydrophila is implicated have involved shellfish, this organism has also been isolated from red meats, poultry and raw milk. This chapter considers the possible involvement of Aeromonas hydrophila in food poisoning under the following main headings: Introduction; Characteristics of Aeromonas; Diseases caused by A. hydrophila ; Epidemiology; Isolation and identification; Pathogenicity; Control measures.
KW - Cows
KW - food poisoning
KW - foods
KW - meat
KW - milk
KW - pathogens
KW - poultry
KW - shellfish
KW - Zoonoses
KW - Aeromonas hydrophila
KW - cattle
KW - Aeromonas
KW - Aeromonadaceae
KW - Aeromonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - domesticated birds
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Nutritional toxicology. Volume III.
A2 - Hathcock, J. N.
T2 - Nutritional toxicology. Volume III.
Y1 - 1989///
CY - San Diego; USA
PB - Academic Press
SN - 0123326036
AD - Experimental Nutrition Branch, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19911428020. Publication Type: Book. Language: English. Subject Subsets: Human Nutrition
N2 - This book provides a review and interpretation of different areas of research involving issues with potential public health or regulatory importance. Topics covered include: Food packaging materials: health implications; Neurotoxicology and food safety assessment; Nutritional and safety implications of oxidized sulfur-containing amino acids; Antinutritive effects of phytate and other phosphorylated derivatives; Interactions of vitamin B6 (pyridoxine) and xenobiotics; Considerations in designing and using standardized diets in toxicological experiments; and Risk/benefit analysis for vitamin supplements.
KW - Nutrition
KW - toxicology
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911428020&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The arboviruses: epidemiology and ecology. Volume IV.
A2 - Monath, T. P.
T2 - The arboviruses: epidemiology and ecology. Volume IV.
Y1 - 1989///
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849343887
AD - Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19900596881. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - In this the 4th of 5 volumes on the epidemiology of arthropod-borne viruses, there are 11 chapters covering Oropouche fever to Venezuelan equine encephalitis. The treatment is similar to that of volumes II, III and V.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Domestic animals
KW - epidemiology
KW - Mosquito-borne diseases
KW - Tickborne diseases
KW - Transmission
KW - Vector-borne diseases
KW - Vectors
KW - Viral diseases
KW - Bunyaviridae
KW - Flaviviridae
KW - Man
KW - Reoviridae
KW - Rhabdoviridae
KW - Togaviridae
KW - Viruses
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - positive-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dsRNA viruses
KW - Mononegavirales
KW - arthropod-borne viruses
KW - viral infections
KW - Animal Health and Hygiene (General) (LL800)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596881&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The arboviruses: epidemiology and ecology. Volume V.
A2 - Monath, T. P.
T2 - The arboviruses: epidemiology and ecology. Volume V.
Y1 - 1989///
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849343895
AD - Division of Vector-Borne Viral Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19900596882. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - This is the final volume of a set of books dealing with the epidemiology of arthropod-borne viruses. It contains 5 chapters dealing with vesicular stomatitis, Wesselsbron virus disease, West Nile fever, western equine encephalomyelitis and yellow fever. The treatment is similar to that of volumes II, III and IV.
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Domestic animals
KW - epidemiology
KW - Mosquito-borne diseases
KW - Tickborne diseases
KW - Transmission
KW - Vector-borne diseases
KW - Vectors
KW - Viral diseases
KW - Bunyaviridae
KW - Flaviviridae
KW - Man
KW - Reoviridae
KW - Rhabdoviridae
KW - Togaviridae
KW - Viruses
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - positive-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dsRNA viruses
KW - Mononegavirales
KW - arthropod-borne viruses
KW - viral infections
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900596882&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The molecular epidemiology of dengue viruses: genetic variation and microevolution.
AU - Trent, D. W.
AU - Manske, C. L.
AU - Fox, G. E.
AU - Chu, M. C.
AU - Kliks, S. C.
AU - Monath, T. P.
JO - Applied Virology Research
JF - Applied Virology Research
Y1 - 1990///
VL - 2
SP - 293
EP - 315
AD - Trent, D. W.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Fort Collins CO 80522, USA.
N1 - Accession Number: 19910504358. Publication Type: Journal Article. Language: English. Number of References: 85 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The molecular epidemiology of dengue viruses is discussed under the headings: introduction; the Flaviviruses; molecular epidemiology of dengue viruses (dengue 2, dengue 1, dengue 3 and 4); dengue virus variation and microevolution (oligonucleotide fingerprint comparisons, nucleotide sequence comparisons); molecular correlates of severe dengue virus disease; conclusions.
KW - Arboviruses
KW - molecular biology
KW - Mosquito-borne diseases
KW - Pathogenesis
KW - reviews
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504358&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sodium, potassium, calcium, phosphorus, and magnesium in foods from the United States Total Diet Study.
AU - Pennington, J. A. T.
AU - Young, B.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1990///
VL - 3
IS - 2
SP - 145
EP - 165
SN - 0889-1575
AD - Pennington, J. A. T.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19911430959. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 7440-70-2, 7439-95-4, 7723-14-0, 7440-09-7, 7440-23-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - Data on the concentrations of sodium, potassium, calcium, phosphorus, and magnesium in the 234 foods of the United States Total diet Study from 1982 to 1989 are summarized per 100 g and typical serving portion. Per serving, mixed dishes and soups were higher in Na; mixed dishes, root/tuber vegetables, and dairy products were higher in K; milk products were higher in Ca; milk products, mixed dishes, and meat were higher in P and nuts, mixed dishes, and legumes were higher in Mg. Of the top 20 foods highest in each element per serving, the coefficients of variation averaged 20% (range 10-48%) for Na (range 2-47) for K, 21 (range 12-24) for Ca, 14 (range 7-22) for P and 17 (range 7-24) for Mg. Nutrient variation reflects genetic, environmental, processing, and analytic factors. Na variability reflects the variable amount of salt added to foods and recipe ingredients by industry.
KW - Calcium
KW - Cows
KW - Diet studies
KW - Foods
KW - Magnesium
KW - milk products
KW - minerals
KW - Phosphorus
KW - Potassium
KW - Sodium
KW - surveys
KW - USA
KW - cattle
KW - Man
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430959&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Iron, zinc, copper, manganese, selenium, and iodine in foods from the United States Total Diet Study.
AU - Pennington, J. A. T.
AU - Young, B.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1990///
VL - 3
IS - 2
SP - 166
EP - 184
SN - 0889-1575
AD - Pennington, J. A. T.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19911430960. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 7440-66-6, 7439-96-5, 7782-49-2, 7440-50-8, 7553-56-2, 7439-89-6. Subject Subsets: Human Nutrition; Dairy Science
N2 - Data on the concentrations of iron, zinc, copper, manganese, selenium, and iodine in the 234 foods of the United States Total Diet Study from 1982 to 1989 are summarized per 100 g and per typical serving portion. Foods highest in these elements per serving were ready-to-eat cereals, mixed dishes, and meats for Fe; meat, mixed dishes, and ready-to-eat cereals for Zn; meat, nuts, mixed dishes and beans/peas for Cu; ready-to-eat cereals, nuts, and beans/peas for Mn; fish, meat, poultry, and mixed dishes for Se; and ready-to-eat cereals, milk desserts, mixed dishes, fish, and milk products for I2. Coefficients of variation for the microelements in the top 20 food sources per serving averaged 28% for Fe, 20 for Zn, 26 for Cu, 25 for Mn, 32 for Se, and 104 for I2. In addition to genetic, environmental, processing, and analytic variables, causes for variability of these microelements in foods, include inconsistent and varying concentrations in fortification with microelements and food additives containing microelements.
KW - copper
KW - Diet studies
KW - Foods
KW - iodine
KW - iron
KW - manganese
KW - Milk products
KW - minerals
KW - selenium
KW - zinc
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - Mn
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430960&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China.
AU - Olenchock, S. A.
AU - Christiani, D. C.
AU - Mull, J. C.
AU - Ye, T. T.
AU - Lu, P. L.
JO - Biomedical and Environmental Sciences
JF - Biomedical and Environmental Sciences
Y1 - 1990///
VL - 3
IS - 4
SP - 443
EP - 451
SN - 0895-3988
AD - Olenchock, S. A.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19922452747. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Agricultural Engineering
N2 - The endotoxin contamination of airborne vertically elutriated and total dusts was studied in order to assess the roles of airborne cotton dust and endotoxins in affecting the respiratory health of cotton textile workers. Yarn preparation areas (opening to fine spinning) were studied at 2 cotton textile mills in China. Endotoxin analyses were performed on filters with vertically elutriated (VE) or total dusts in duplicate with the quantitative chromotenic modification of the Limulus amebocyte lysate assay. Dusts from all areas of the textile mills contained endotoxins. Endotoxin burdens in VE dusts from the carding area were similar in both mills, while the endotoxin contamination of total dust from carding in Mill 1 was over 3 times greater than that of total dust from carding in Mill 2. All other areas differed between mills in both VE and total dust endotoxin burdens. Mean endotoxin levels in VE dusts from all areas of both mills were well above the reported threshold of 90 endotoxin units /m³ for acute pulmonary function effects in humans. Comparison of selected areas of both mills with results from a previous study showed that, in general, the airborne endotoxin burden was higher than 5 years previously. The data suggest that even with reduced or unchanged gravimetric dust levels in these two cotton textile mills, airborne endotoxin levels were higher and provided increased potential for adverse respiratory response in exposed workers.
KW - air pollution
KW - cotton
KW - endotoxins
KW - Health protection
KW - mills
KW - Pollution
KW - workers
KW - China
KW - Gossypium
KW - man
KW - Malvaceae
KW - Malvales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - atmospheric pollution
KW - environmental pollution
KW - People's Republic of China
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
KW - Pollution and Degradation (PP600)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922452747&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Past, present and future of Aedes albopictus in the United States.
AU - Francy, D. B.
AU - Moore, C. G.
AU - Eliason, D. A.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1990///
VL - 6
IS - 1
SP - 127
EP - 132
SN - 8756-971X
AD - Francy, D. B.: Center for Infectious Diseases, Public Health Service, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19900599595. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Aedes albopictus was first detected in Houston, Texas, in 1985. Since then it has spread to 17 states and 122 counties. This exotic species from Asia appears to have arrived in the USA in imported used tyre casings. Public health concerns have been raised regarding the potential of this species to serve as a vector of arboviruses indigenous to the USA, such as La Crosse encephalitis, and also for imported dengue. The division of Vector-Borne Viral Diseases, Centers for Disease Control, has actively pursued a programme to determine the distribution of A. albopictus in the USA, monitor the spread of the species and implement procedures that would eliminate the risk of further importation of exotic mosquitoes in used tyre casings. The latter goal was achieved in large measure in 1988 with a 98% reduction in imported used tyres containing water. The ultimate consequences of establishment of A. albopictus in the USA is unknown; however, because of its biologic characteristics and broad viral susceptibility, it seems likely that this species will eventually become involved as an arbovirus vector in the USA.
KW - arboviruses
KW - disease vectors
KW - distribution
KW - Geographical distribution
KW - Introduced species
KW - Quarantine
KW - reviews
KW - Tyres
KW - vectors
KW - North America
KW - USA
KW - Aedes albopictus
KW - Culicidae
KW - Diptera
KW - La Crosse virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - America (North)
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - tires
KW - United States of America
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Aquatic Biology and Ecology (MM300)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900599595&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Machine safety research at National Institute for Occupational Safety and Health.
AU - Etherton, J. R.
AU - Myers, M. L.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 1990///
VL - 6
IS - 2
SP - 163
EP - 174
AD - Etherton, J. R.: National Institute for Occupational Safety and Health (NIOSH), 944 Chestnut Ridge Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19912450323. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Agricultural Engineering
N2 - Results of a NIOSH analysis of data on all types of machine-related fatality and injury are reported, covering machines from the agricultural, construction and manufacturing industries. The data analysis used death certificate and workers' compensation information to rank types of machines needing research. Results of a meeting at which priorities in manufacturing machine safety research were discussed are also presented. Human factors in robotized workplaces, reliability of machine safety devices and machine-related injury data for different machine types were among the subjects discussed. Farm tractors, industrial presses, saws, fork lifts, and shears and slicers were identified as machines with high severity and frequency of injuries. Additional work is also justified in the emerging technology of robotic safety.
KW - Accident prevention
KW - farm machinery
KW - research
KW - robots
KW - Safety
KW - tractors
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - studies
KW - United States of America
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Research (AA500)
KW - Engineering and Equipment (General) (NN000)
KW - Automation and Control (NN050)
KW - Farm Vehicles as Power Sources (NN200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912450323&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aedes albopictus and other container-inhabiting mosquitoes in the United States: results of an eight-city survey.
AU - Moore, C. G.
AU - Francy, D. B.
AU - Eliason, D. A.
AU - Bailey, R. E.
AU - Campos, E. G.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1990///
VL - 6
IS - 2
SP - 173
EP - 178
SN - 8756-971X
AD - Moore, C. G.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900500464. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Extensive surveys were conducted in 1987 in Baytown, Texas; Lafayette, Shreveport and Baton Rouge, Louisiana; Memphis, Tennessee; Kansas City, Missouri; Evansville, Indiana; and Jacksonville, Florida. The programme objective was to determine the intensity of A. albopictus infestations, to evaluate the degree to which A. albopictus had spread into residential areas, to document habitat selection and to obtain background information for possible suppression or eradication projects. This report described the survey methods and presents a preliminary analysis of the data. Larvae, pupae and adult mosquitoes were collected from container habitats in a randomized selection of urban premises as well as at and around sites known to be at high risk for introduction of A. albopictus. Adult or larval mosquitoes were collected from 24.4% of 5728 premises inspected, and there were an average of 3.27 positive containers per positive premise. Several known disease vectors, especially Culex pipiens s.l., were frequently found in urban container habitats.
KW - disease vectors
KW - Dispersal
KW - Ecology
KW - Geographical distribution
KW - Habitats
KW - Introduced species
KW - Surveys
KW - urban areas
KW - Vectors
KW - Water containers
KW - Florida
KW - Indiana
KW - Louisiana
KW - Missouri
KW - North America
KW - Tennessee
KW - Texas
KW - USA
KW - Aedes albopictus
KW - Culex pipiens
KW - Culicidae
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - Delta States of USA
KW - West South Central States of USA
KW - West North Central States of USA
KW - Appalachian States of USA
KW - East South Central States of USA
KW - Great Plains States of USA
KW - Southern Plains States of USA
KW - Southwestern States of USA
KW - Asian tiger mosquito
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Biological Resources (Animal) (PP710)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500464&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vertical transmission of dengue viruses by strains of Aedes albopictus recently introduced into Brazil.
AU - Mitchell, C. J.
AU - Miller, B. R.
AU - Shroyer, D. A.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1990///
VL - 6
IS - 2
SP - 251
EP - 253
SN - 8756-971X
AD - Mitchell, C. J.: Division of Vector-borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900500475. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Three strains of A. albopictus from Brazil (2 from Espírito Santo State and 1 from São Paulo) were examined for their ability to vertically transmit dengue 1 (DEN-1) and dengue 4 (DEN-4) viruses. Parental females were uniformly infected by parenteral inoculation of virus, and 8121 F1 progeny from DEN-1 and DEN-4 infected mothers were pooled in lots of approximately 50 individuals and tested for virus. Seven of 60 pools were positive for DEN-1 virus, and 1 of 121 pools was positive for DEN-4 virus. In DEN-1 assays, the minimum infection rate (MIR) for larvae (2 pools tested) was 1:84. Among positive cohorts of adults, pooled by sex and by geographic strain of mosquito, the MIR ranged from 1:193 to 1:626 for males and from 1:187 to 1:311 for females. Only a single pool of adult females was positive for DEN-4 virus (MIR 1:1022 for an adult female cohort from Santa Teresa, Espírito Santo). These results indicate that Brazilian A. albopictus have the potential to play a role in the maintenance of dengue viruses in nature.<new para>ADDITIONAL ABSTRACT:<new para>The authors conclude from their laboratory studies on 3 separate strains that Brazilian Aedes albopictus have the potential to play a role in the maintenance of dengue viruses in nature. Vertical transmission was greater for DEN-1 virus than for DEN-4.[Later in this issue (pp. 312-314) D.A. Shroyer reports that vertically infected Ae. albopictus (originally from Hawaii) are more efficient vertical transmitters of DEN-1 virus than females infected horizontally by inoculation: 3 of 4 vertically infected females transmitted virus to their offspring compared with only ≤0.7% of females infected by inoculation.]Carolyn A. Brown
KW - Arboviruses
KW - disease transmission
KW - disease vectors
KW - Transmission
KW - Vector competence
KW - vectors
KW - vertical transmission
KW - Brazil
KW - Espirito Santo
KW - Sao Paulo
KW - South America
KW - Aedes albopictus
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - Flaviviridae
KW - Flavivirus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Brazil
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500475&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dehydroepiandrosterone on the growth, biochemical changes, and metabolism of aflatoxin B1 in human fibroblast cell cultures.
AU - Prasanna, H. R.
AU - Nakamura, K. D.
AU - Lu, M. H.
AU - Hart, R. W.
JO - Biochemical Archives
JF - Biochemical Archives
Y1 - 1990///
VL - 6
IS - 3
SP - 253
EP - 260
SN - 0749-5331
AD - Prasanna, H. R.: FDA, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19921212365. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The influence of dehydroepiandrosterone (DHEA), an adrenal steroid and an anticarcinogen, on the cell growth, subcellular constituents, and metabolism of aflatoxin B1 (AFB1) were investigated in human fibroblast cell cultures. DHEA significantly increased mean cellular volume, protein content, and glutathione transferase activity (2 to 4 fold). Higher amounts of AFB1 (1.9 fold) was associated with TCA precipitable proteins from the steroid-treated cells. Additionally, more AFB1-derived water soluble metabolites were excreted into the media (2.5 fold) of DHEA-treated cells. It is suggested that DHEA can mimic some of its hepatic effects in human fibroblast cell cultures.
KW - Aflatoxins
KW - cell cultures
KW - metabolism
KW - Mycotoxins
KW - fungal toxins
KW - Plant Composition (FF040)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212365&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of Aedes albopictus for a newly recognized Bunyavirus from mosquitoes collected in Potosi, Missouri.
AU - Mitchell, C. J.
AU - Smith, G. C.
AU - Miller, B. R.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1990///
VL - 6
IS - 3
SP - 523
EP - 527
SN - 8756-971X
AD - Mitchell, C. J.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19910502930. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The vector competence of a Kentucky strain of A. albopictus was assessed for a newly recognized Bunyavirus isolate from A. albopictus collected in Potosi, Missouri. Females are susceptible to peroral infection and 44.7% became infected after ingesting about 15 Vero cell plaque-forming units (PFU) of virus. Virus replicated and reached average titres of 105.4-106.0 PFU/mosquito by day 7 postfeeding. Fourteen (40%) of 35 females tested in an in vitro virus transmission experiment were infected, and 3 (21.4%) of the infected females transmitted virus. There was no evidence of vertical transmission among 1196 progeny of a group of mothers exposed to infection perorally or among 6635 progeny of mother infected by parenteral inoculation. The absence or infrequency of vertical transmission suggests that the virus was not introduced into Missouri via infected A. albopictus eggs. Nonetheless, A. albopictus is a competent vector of this virus and the first experimental evidence for incriminating A. albopictus as a vector in a natural arbovirus transmission cycle in the USA is provided.
KW - Arboviruses
KW - disease vectors
KW - introduced species
KW - vector competence
KW - vectors
KW - Missouri
KW - North America
KW - USA
KW - Aedes albopictus
KW - Bunyaviridae
KW - Culicidae
KW - Diptera
KW - Orthobunyavirus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Bunyaviridae
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - Bunyavirus
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910502930&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neosartorya fischeri var fischeri (Wehmer) Malloch and Cain 1972 (anamorph: Aspergillus fischerianus Samson and Gams 1985) as a cause of mycotic keratitis.
AU - Coriglione, G.
AU - Stella, G.
AU - Gafa, L.
AU - Spata, G.
AU - Oliveri, S.
AU - Padhye, A. A.
AU - Ajello, L.
AU - Padhye, A. A.
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
Y1 - 1990///
VL - 6
IS - 4
SP - 382
EP - 385
SN - 0393-2990
AD - Coriglione, G.: A. A. Padhye, Division of Mycotic Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19911208612. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A case of mycotic keratitis caused by N. fischeri var. fischeri is reported in a 62-yr-old man in Italy, who had no history of trauma to his infected left eye. The infection progressed despite treatment with ketoconazole (400 mg/d orally and intravenously) and the eye had to be eviscerated. Histological studies revealed the presence of hyaline, septate mycelium in the eye tissue. Cultures gave rise to a thermotolerant mould that developed both its asexual and sexual forms. The isolate was identified on the basis of the morphological features of its anamorphic and teleomorphic states. A literature review revealed only 7 other species of Aspergillus that have been unequivocally reported as causing mycotic keratitis.
KW - eyes
KW - hosts
KW - infections
KW - Italy
KW - man
KW - Trichocomaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neosartorya
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - fungus
KW - Neosartorya fischeri
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208612&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector-spirochete relationships in louse-borne and tick-borne borrelioses with emphasis on Lyme disease.
AU - Burgdorfer, W.
AU - Hayes, S. F.
JO - Advances in Disease Vector Research
JF - Advances in Disease Vector Research
Y1 - 1990///
VL - 6
SP - 127
EP - 150
CY - New York; USA
PB - Springer-Verlag
SN - 0387970800\3540970800
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Pathobiology, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19910502000. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Salient findings on the development and transmission of Borrelia burgdorferi in and through its Ixodes vectors are compared and contrasted with these aspects of B. recurrentis, B. duttonii and B. theileri (among other borreliae) in their respective louse (Pediculus humanus) and tick (Ornithodoros moubata, Rhipicephalus spp., Boophilus spp.) vectors. After a brief historical introduction, a table summarizes the characteristics and geographical distribution of all arthropod-borne borreliae. Three sections then follow on the behaviour of louse-borne and tick-borne spirochaetes, of B. theileri, and of B. burgdorferi in their vectors, then a section on the relationship of B. burgdorferi to non-specific tick vectors (notably Dermacentor variabilis, Amblyomma americanum, and ticks of the jack rabbit Lepus californicus californicus) and other haematophagous arthropods (Chrysops callidus, Aedes spp.), and finally a section identified "B. burgdorferi: subject to a complex development cycle? ". In conclusion, the main points and areas for further research in this fast-moving subject are highlighted, including the apparent relative unimportance of transovarial transmission for B. burgdorferi, the likelihood that Haemaphysalis leporipalustris and I. dentatis play a role in maintaining B. burgdorferi in lagomorph populations, the possibility of mechanical transmission by Chrysops, Tabanus and mosquitoes, and certain complexities of spirochaete development in their arthropod and vertebrate hosts.
KW - disease vectors
KW - host parasite relationships
KW - reviews
KW - Tickborne diseases
KW - vectors
KW - Zoonoses
KW - Acari
KW - Anoplura
KW - Arachnida
KW - Argasidae
KW - Borrelia
KW - Borrelia burgdorferi
KW - Borrelia duttonii
KW - Borrelia recurrentis
KW - Borrelia theileri
KW - Culicidae
KW - Diptera
KW - Ixodes scapularis
KW - Ixodidae
KW - Lagomorpha
KW - Leporidae
KW - Mammals
KW - Pediculus
KW - Phthiraptera
KW - Spirochaetaceae
KW - Tabanidae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - Metastigmata
KW - Acari
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Borrelia
KW - Diptera
KW - Ixodes
KW - Ixodidae
KW - mammals
KW - vertebrates
KW - Chordata
KW - Lagomorpha
KW - Pediculidae
KW - Anoplura
KW - bacterium
KW - Ixodes dammini
KW - Louse-borne diseases
KW - mosquitoes
KW - parasite host relationships
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910502000&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of chronic caloric restriction on the synchronization of various physiological measures in old female Fischer 344 rats.
AU - Duffy, P. H.
AU - Feuers, R.
AU - Nakamura, K. D.
AU - Leakey, J.
AU - Hart, R. W.
JO - Chronobiology International
JF - Chronobiology International
Y1 - 1990///
VL - 7
IS - 2
SP - 113
EP - 124
AD - Duffy, P. H.: Department of Health and Human Services, Public Health Service, Food and Drug Administration, National Center for Toxicological Resarch, Jefferson, AR 72079, USA.
N1 - Accession Number: 19921445730. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A variety of physiological and behavioural parameters which relate to metabolism were continuously monitored in 18-month-old female Fischer 344 rats which were maintained on either ad libitum or reduced energy diets. Energy restriction (ER) stimulated average motor activity per day, the duration of each feeding episode, food consumed per episode, and water consumed per g lean body mass (LBM). However, ER limited total food consumption, feeding time, number of feeding episodes per day, total eating and drinking time, and the daily ratio of food consumed to water consumed. It also decreased average body temperature per day, O2 consumption, CO2 production and respiratory quotient. Parameters concerning water consumption were not affected. ER rats ate their food immediately it was presented during the light span, while ad libitum fed animals ate numerous small meals throughout the entire dark span. An anticipatory response to restricted feeding was also noted. Total motor activity, metabolism and body temperature increased just prior to scheduled feeding, and reached maximum values shortly after feeding, suggesting that these parameters were highly synchronized to feeding. Females and males were found to respond to ER in a similar fashion. Marked changes in respiratory quotient and body temperature suggested that rapid shifts between metabolic pathways (glycolysis to gluconeogenesis) occurred to obtain optimal efficiency. Lower body temperature and metabolism may provide protection against DNA damage, thereby increasing the survival potential of restricted rats. These responses may provide insight into the mechanisms by which ER extends lifespan.
KW - behaviour
KW - body temperature
KW - energy intake
KW - feeding behaviour
KW - metabolism
KW - Old age
KW - physical activity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - feeding behavior
KW - Animal Behaviour (LL300)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921445730&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of polyethylene terephthalate cyclic trimer migration from microwave food packaging using temperature-time profiles.
AU - Begley, T. H.
AU - Hollifield, H. C.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1990///
VL - 7
IS - 3
SP - 339
EP - 346
SN - 0265-203X
AD - Begley, T. H.: Food and Drug Administration, Division of Food Chemistry and Technology, Washington, DC 20204, USA.
N1 - Accession Number: 19911433441. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - A procedure was developed to predict the potential of the polymer polyethylene terephthalate (PET), used for packaging food that will be heated or cooked in the PET container, to migrate from the container into the food. Migration experiments using crystallized (CPET) and maize oil were made at 115°, 146° and 176°C. Diffusion coefficients were calculated for the cyclic trimer in PET. Predicted values were in good agreement with measured results.
KW - Food contamination
KW - packaging materials
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433441&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A review of sulphites in foods: analytical methodology and reported findings.
AU - Fazio, T.
AU - Warner, C. R.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1990///
VL - 7
IS - 4
SP - 433
EP - 454
SN - 0265-203X
AD - Fazio, T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Physical Sciences, Washington, DC 20204, USA.
N1 - Accession Number: 19911430694. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition
N2 - Analytical methods for estimating sulphites in foods are reviewed, with a critique of their chemistry and procedural schemes. An assessment of the key features of each method category is presented together with some comparative data. The classification scheme used is based on the fact that estimation of the sulphite content of a food is influenced more by the treatment and cleanup of the test solution than by the final determination step. The Monier-Williams procedure still remains the method of choice.
KW - estimation
KW - foods
KW - reviews
KW - SULFITES
KW - sulphites
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430694&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi.
AU - Simpson, W. J.
AU - Garon, C. F.
AU - Schwan, T. G.
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 1990///
VL - 8
IS - 2
SP - 109
EP - 118
SN - 0882-4010
AD - Simpson, W. J.: Department of Health and Human Services, Public Health Service, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19950800299. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
KW - human diseases
KW - Lyme disease
KW - plasmids
KW - Borrelia burgdorferi
KW - Spirochaetaceae
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800299&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Salmonella enteritidis contamination of whole chicken eggs.
AU - Madden, J. M.
JO - Dairy, Food and Environmental Sanitation
JF - Dairy, Food and Environmental Sanitation
Y1 - 1990///
VL - 10
IS - 5
SP - 268
EP - 270
SN - 1043-3546
AD - Madden, J. M.: Division of Microbiology, Center for Food Safety & Applied Nutrition, US Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901361636. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 9 ref. Subject Subsets: Veterinary Science; Poultry
N2 - Data on egg-related outbreaks of S. enteritidis in the USA are presented. Transmission, control of S. enteritidis in eggs, research plans, education and mandatory testing are discussed.
KW - biodeterioration
KW - Eggs
KW - Food hygiene
KW - pathogens
KW - USA
KW - Bacteria
KW - Salmonella enteritidis
KW - prokaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - International Association of Milk, Food and Environmental Sanitarians
KW - United States of America
KW - Biodeterioration (SS300)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901361636&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alterations in β-carotene and vitamin E status in rats fed β-carotene and excess vitamin A.
AU - Blakely, S. R.
AU - Grundel, E.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1990///
VL - 10
IS - 9
SP - 1035
EP - 1044
SN - 0271-5317
AD - Blakely, S. R.: Food and Drug Administration (HFF-268), 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901453056. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 7235-40-7, 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Groups of 10 male weanling Sprague-Dawley rats were given freely for 8 weeks diets containing vitamin A and β-carotene in a 3 × 3 factorial design. Retinyl palmitate was given at the USA National Research Council's recommended requirement value of 4000 IU/kg diet (control), 10 times the requirement (A1) and 100 times the requirement (A2). Each of these groups was given β-carotene 0, 48 (BC1) or 480 mg/kg (BC2) diet. Liver vitamin A values increased and were 100-fold higher in A2 groups than in the control group. Retinyl esters increased in the liver; retinyl stearate increased as a result of β-carotene treatments. Liver β-carotene was significantly reduced in A1-BC and A2-BC2 groups compared with values for the control-BC2 group. In the A2-BC2 group, plasma vitamin E was reduced 77% compared with control values; hepatic microsomal cytochrome P-450 and its isozyme, benzephetamine demethylase, were lower and the specific activity of glutathione S-transferase was increased. The findings suggest that vitamin E state can be altered by ingesting excessive vitamin A or β-carotene and that vitamin A and β-carotene changed the biodegradation and detoxification capacity of the liver in rats.
KW - beta-Carotene
KW - blood
KW - Retinol
KW - vitamin E
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901453056&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Correlations of dietary intake and blood nutrient levels with esophageal cancer mortality in China.
AU - Guo, W. D.
AU - Li, J. Y.
AU - Blot, W. J.
AU - Hsing, A. W.
AU - Chen, J. S.
AU - Fraumeni, J. F., Jr.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1990///
VL - 13
IS - 3
SP - 121
EP - 127
SN - 0163-5581
AD - Guo, W. D.: W.J. Blot, Biostatistics Branch, EPN, Suite 431, Public Health Service, NCI, NIH, Bethesda, MD 20892-4200, USA.
N1 - Accession Number: 19901451642. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition
N2 - Using dietary, blood nutrient and oesophageal cancer mortality data from 65 Chinese counties, several correlations were examined to help provide clues to the influence of diet and nutrition on the geographic variation of oesophageal cancer in China. Oesophageal cancer mortality was significantly and inversely related to reported fruit consumption and to plasma ascorbic acid concentration. The age-adjusted mortality rates were more than 3 times higher for counties in the lowest compared with the highest quartile of fruit intake or plasma vitamin C. Positive correlations with intake of mouldy vegetables were observed but not with tobacco and alcohol consumption. There were suggestive inverse associations with blood selenium and riboflavin but little effect of fat-soluble vitamins. Limitations of ecological data preclude causal inferences, but the relations provide leads to dietary factors that may contribute to the exceptionally high rates of oesophageal cancer in several areas of China.
KW - Carcinoma
KW - diets
KW - nutrition
KW - oesophagus
KW - China
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - esophagus
KW - People's Republic of China
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451642&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antitumor activity in skin of Skh and Sencar mice by two dietary β-carotene formulations.
AU - Lambert, L. A.
AU - Koch, W. H.
AU - Wamer, W. G.
AU - Kornhauser, A.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1990///
VL - 13
IS - 4
SP - 213
EP - 221
SN - 0163-5581
AD - Lambert, L. A.: Division of Toxicology (HFF-164), US Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901451651. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
N2 - There is currently a great interest in the protective potential of β-carotene and other micronutrients against carcinogenesis. The role of β-carotene in modifying 7,12-dimethylbenz[a]anthracene (DMBA)-initiated, 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted, two-stage skin carcinogenesis was studied, comparing the protective effects of two types of dietary β-carotene, a beadlet formulation and crystalline β-carotene, in two strains of mice (Skh:HR-1 and CR:ORL Sencar). Mice were maintained throughout the study on one of these 3% β-carotene-fortified diets or on control diets. In week 11 after the start of the diets, the DMBA/TPA treatment was begun. The resulting skin tumours were counted weekly. In addition, serum and skin values were monitored for β-carotene at the time of chemical initiation and at the end of the study. A decrease in the number of cumulative tumours in the β-carotene-fed mice compared with the appropriate control groups was observed in both strains. However, statistical evaluation of the data revealed that the decrease was significant only in Skh mice. This phenomenon might be explained by the inherent sensitivity of Sencar mice to the two-stage carcinogenesis treatment. The mechanism of the protective effect in this study is not clear. Recent data suggest that a vitamin A pathway is not probable but that a direct 1O2 and/or radical-quenching property of the parent β-carotene molecule may be involved. This study also demonstrates that two-stage-induced skin tumorigenesis can be modified by both types of β-carotene-fortified diets.
KW - beta-carotene
KW - Carcinoma
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451651&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of selected organochlorine pesticides and polychlorinated biphenyls in human serum.
AU - Burse, V. W.
AU - Head, S. L.
AU - Korver, M. P.
AU - McClure, P. C.
AU - Donahue, J. F.
AU - Needham, L. L.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 1990///
VL - 14
IS - 3
SP - 137
EP - 142
SN - 0146-4760
AD - Burse, V. W.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900500405. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 50-29-3, 60-57-1, 72-20-8, 608-73-1, 76-44-8. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - A method is presented that can be used to determine the residue level of certain chlorinated pesticides and polychlorinated biphenyls (as Aroclor 1260) in serum. The method involves the following: (1) extraction of denatured serum with organic solvents; (2) elution of the organic extract through micro-Florisil columns to obtain 2 fractions; (3) acid treatment of the less polar Florisil fraction and its subsequent elution through deactivated silica gel to obtain 2 fractions; and (4) analysis of all 3 fractions using gas-liquid chromatography with electron capture detection. The method produced in vitro recoveries for 10 pesticides (including DDT, dieldrin, endrin, HCH and heptachlor epoxide) spiked in the range of 1-10.7 p.p.b. of 50.4% to 121.6%, and in the range of 4.98-21 p.p.b., recoveries ranged from 47.7 to 112.6. In vivo 'recoveries' of Aroclor 1260 averaged 104.8% and 92.3% for concentration levels of ~10 and ~30 p.p.b., respectively. The method could not be compared with the more commonly used hexane extraction technique because of the deleterious effect these extracts had on the gas chromatographic system.
KW - agricultural entomology
KW - analytical methods
KW - DDT
KW - determination
KW - Dieldrin
KW - Endrin
KW - Gas chromatography
KW - HCH
KW - Heptachlor
KW - Insecticide residues
KW - insecticides
KW - Nontarget effects
KW - Organochlorine insecticides
KW - Organochlorine pesticides
KW - Pesticide residues
KW - pesticides
KW - Polychlorinated biphenyls
KW - residues
KW - serum
KW - Techniques
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - benzene hexachloride
KW - BHC
KW - dicophane
KW - organic chlorine pesticides
KW - PCBs
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500405&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential compounds for monitoring method performance in the determination of selected organochlorine pesticides and polychlorinated biphenyls in human serum.
AU - Burse, V. W.
AU - McClure, P. C.
AU - Korver, M. P.
AU - Head, S. L.
AU - Needham, L. L.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 1990///
VL - 14
IS - 3
SP - 143
EP - 145
SN - 0146-4760
AD - Burse, V. W.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900500406. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - Four compounds - 2,2′,3,4′-tetrachlorobiphenyl, decachlorodiphenylether, 1,1-dichloro-2,2-bis(p-ethylphenyl)ethane and dichlorobenzophenone - are recommended for monitoring the within-sample behaviour of an analytical method that quantifies chlorinated pesticides and polychlorinated biphenyls (such as Aroclor 1260) in serum using packed column gas chromatography with electron capture detection. Percent recoveries of these surrogates averages >80%, except with dichlorobenzophenone, which had an average recovery of >70%.
KW - agricultural entomology
KW - analytical methods
KW - determination
KW - Gas chromatography
KW - Insecticide residues
KW - insecticides
KW - Nontarget effects
KW - Organochlorine insecticides
KW - Organochlorine pesticides
KW - Pesticide residues
KW - pesticides
KW - Polychlorinated biphenyls
KW - residues
KW - serum
KW - Techniques
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - organic chlorine pesticides
KW - PCBs
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500406&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Laboratory investigation of a poisoning epidemic in Sierra Leone.
AU - Hill, R. H., Jr.
AU - Alley, C. C.
AU - Ashley, D. L.
AU - Cline, R. E.
AU - Head, S. L.
AU - Needham, L. L.
AU - Etzel, R. A.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 1990///
VL - 14
IS - 4
SP - 213
EP - 216
SN - 0146-4760
AD - Hill, R. H., Jr.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900500953. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 56-38-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - In June 1986, an epidemic of poisoning occurred in Sierra Leone, West Africa; it involved 49 persons - with 14 deaths. The Centers for Disease Control (Atlanta) laboratory's approach and investigation of this incident is described. Using positive chemical ionization mass spectrometry and nuclear magnetic resonance spectroscopy, the toxicant was identified as parathion, a highly toxic organophosphorus pesticide. Analysis of various items supported the epidemiologic hypothesis that bread was made from contaminated flour and that the flour became contaminated with parathion during a truck shipment. Modern analytical instruments played a major role in this laboratory investigation and effected the identification of the unknown toxicant within hours of receiving the initial bread sample. Close cooperation and clear communication between the epidemiologic and laboratory teams were important in this investigation.
KW - agricultural entomology
KW - Analytical methods
KW - effects
KW - Insecticides
KW - nontarget effects
KW - Organophosphorus insecticides
KW - Parathion
KW - pesticides
KW - poisoning
KW - Africa
KW - Sierra Leone
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - analytical techniques
KW - ethyl-parathion
KW - Mass spectroscopy
KW - toxicosis
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500953&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Amoebae isolated from laboratory eyewash stations.
AU - Bier, J. W.
AU - Sawyer, T. K.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 1990///
VL - 20
IS - 5
SP - 349
EP - 350
SN - 0343-8651
AD - Bier, J. W.: Division of Microbiology (HFF-234), Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19900864471. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7732-18-5. Subject Subsets: Protozoology
N2 - Amoebae of 5 genera (Hartmannella, Vahlkampfia, Schizopyrenus, Acanthamoeba and Echinamoeba) were isolated from 31 of 56 eyewash stations in a federal laboratory and office building in Washington, DC, USA. Eyewash stations that contained a reservoir presented a greater hazard than those without a reservoir. The need to flush eyewash stations regularly as part of safe laboratory practices is emphasized.
KW - Eyes
KW - Free living amoebae
KW - Human diseases
KW - parasites
KW - Water
KW - North America
KW - USA
KW - Acanthamoeba
KW - Hartmannella
KW - protozoa
KW - Sarcomastigophora
KW - Vahlkampfia
KW - Acanthamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Hartmanellidae
KW - Vahlkampfiidae
KW - Schizopyrenida
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Echinamoeba
KW - laboratory eyewash stations
KW - prevalence
KW - Schizopyrenus
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864471&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran in cow's milk.
AU - Glidden, R. M.
AU - Brown, P. J.
AU - Sittig, R. A.
AU - Syvertson, C. N.
AU - Smith, P. V.
JO - Chemosphere
JF - Chemosphere
Y1 - 1990///
VL - 20
IS - 10-12
SP - 1619
EP - 1624
SN - 0045-6535
AD - Glidden, R. M.: US Food and Drug Administration, Chicago District Laboratory, 10 W. 35th Street, Chicago, IL 60616, USA.
N1 - Accession Number: 19910446088. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A method is described for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran at sub parts per 1012 levels. The results of a limited survey of US milk packaged in bleached paper cartons are presented.
KW - chromatography
KW - Cows
KW - determination
KW - milk
KW - milk cartons
KW - Polychlorinated dibenzodioxins
KW - Polychlorinated dibenzofurans
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Milking and Dairy Equipment (NN490) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition education for Indian elders.
AU - Jackson, M. Y.
AU - Mead, P.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1990///
VL - 22
IS - 6
SP - 311
EP - 313
SN - 0022-3182
AD - Jackson, M. Y.: Nutrition and Dietetics Section, Indian Health Service, 5600 Fishers Lane, Room 6A-38, Rockville, MD 20832, USA.
N1 - Accession Number: 19911439497. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - A 1980 census identified 1 423 042 individuals as American Indians, of which 7.6% were ≥60 years old. Food plays a central role in reaffirming their cultural heritage and nutrition educators must utilize the unique socioeconomic and cultural factors influencing nutrition and health related behaviour in providing relevant nutrition education for elderly American Indians. Important issues for consideration when designing nutrition education for this population are discussed.
KW - ethnic groups
KW - nutrition education
KW - Old age
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911439497&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pimozide in delusions of parasitosis.
AU - Damiani, J. T.
AU - Flowers, F. P.
AU - Pierce, D. K.
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
Y1 - 1990///
VL - 22
IS - 2, Part 1
SP - 312
EP - 313
SN - 0190-9622
AD - Damiani, J. T.: US Public Health Service, Cross City, Florida, USA.
N1 - Accession Number: 19920504129. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 2062-78-4. Subject Subsets: Medical & Veterinary Entomology
N2 - The case history is given of a 70-year-old white woman with an 8-month history of burning and itching of the scalp. She had been treated without success with antibiotics and shampoos. Prurigo nodularis was diagnosed after physical and laboratory examination and she was treated with oral doxepin, 25 mg daily. Shortly thereafter it became evident that her complaint was delusional parasitosis, and since this is a type of monosymptomatic hypochondriac psychosis (MHP) her treatment was replaced with pimozide, a medication approved for treatment of chronic schizophrenia and Tourette syndrome and which has also been found effective in treatment of MHP. After 1 month of oral pimozide 1 mg twice daily she was much improved and after 2 mg twice daily the symptoms subsided completely. On discontinuation at 6 months the delusions returned, but after returning to 2 mg twice daily her symptoms were under control for an additional year. Other workers have found that in a large proportion of patients with delusions of parasitosis a cure was effected within 3-5 months of pimozide therapy. Long-term treatment with this drug may induce serious side-effects, however.
KW - Case reports
KW - Delusory parasitoses
KW - Drug therapy
KW - Neuroleptics
KW - pimozide
KW - therapy
KW - Florida
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - chemotherapy
KW - sedatives
KW - therapeutics
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920504129&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Child fostering, health and nutritional status: the experience of Swaziland.
AU - Sudre, P.
AU - Serdula, M.
AU - Binkin, N.
AU - Staehling, N.
AU - Kramer, M.
JO - Ecology of Food and Nutrition
JF - Ecology of Food and Nutrition
Y1 - 1990///
VL - 24
IS - 3
SP - 181
EP - 188
SN - 0367-0244
AD - Sudre, P.: Division of Nutrition, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19911430058. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - A nutrition survey made in 1983 in rural Swaziland on 4683 children <6 years old allowed an examination of fostering practices and their association with health services utilization and nutritional state. Fostered children are defined as those whose biologic mother is not a member of the homestead or is absent more than 50% of the time. Fostering increased with age. Guardians were older than biologic mothers and had a lower literacy rate. Fostered children were less likely than non-fostered children to be fully immunized. Fostered and non-fostered children had similar histories of maternal and child health clinic attendance. After adjustment for socio-demographic factors, nutritional state of fostered and non-fostered children did not differ significantly. The study showed a high prevalence of fostering, but did not support the hypothesis of an association between fostering and poorer health as measured by nutritional state.
KW - Children
KW - fostering
KW - nutritional state
KW - Swaziland
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - SADC Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - nutritional status
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430058&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recovery of fish oil-derived fatty acids in lymph of thoracic duct-cannulated Wistar rats.
AU - Reicks, M.
AU - Hoadley, J.
AU - Satchithanandam, S.
AU - Morehouse, K. M.
JO - Lipids
JF - Lipids
Y1 - 1990///
VL - 25
IS - 1
SP - 6
EP - 10
SN - 0024-4201
AD - Reicks, M.: Food and Drug Administration, 200 C St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19921450419. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 25167-62-8, 10417-94-4. Subject Subsets: Human Nutrition
N2 - The absorption of equivalent doses of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was compared in rats when administered as the ethyl ester concentrate, ethyl ester concentrate plus olive oil, free fatty acid or triacylglycerol (menhaden oil). Lymph was collected from a thoracic duct cannula for 24 h after dosing via an indwelling duodenal catheter. After 24 h, the absorption of EPA was greater for the free fatty acid and menhaden oil than for the ethyl ester form, but DHA absorption was similar for all forms. Other rats had greater plasma EPA and DHA values 5 h after oral gavage dosing with menhaden oil than did rats dosed with the ethyl ester form.
KW - Docosahexaenoic acid
KW - Eicosapentaenoic acid
KW - fatty acids
KW - Fish oils
KW - lymph
KW - sources
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921450419&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antigenic relationship of Dactylaria gallopava to Scolecobasidium constrictum.
AU - Sekhon, A. S.
AU - Padhye, A. A.
AU - Standard, P. G.
AU - Kaufman, L.
AU - Ajello, L.
AU - Garg, A. K.
JO - Journal of Medical and Veterinary Mycology
JF - Journal of Medical and Veterinary Mycology
Y1 - 1990///
VL - 28
IS - 1
SP - 59
EP - 66
SN - 0268-1218
AD - Sekhon, A. S.: A. A. Padhye, Division of Mycotic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19901206309. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The antigenic relationship of D. gallopava [Ochroconis gallopavum] to S. constrictum was studied using the exoantigen procedure. Exoantigens were prepared from 20 isolates of O. gallopavum, 7 of S. constrictum and 2 of S. tschawytschae and were tested against reference rabbit anti-O. gallopavum and anti-S. constrictum antisera in the presence of their homologous antigens using the micro-immunodiffusion technique. All O. gallopavum isolates produced 2-3 distinct, identical exoantigens. The 7 isolates of S. constrictum also produced 2-3 distinct exoantigens. None of the 7 isolates of S. constrictum was reactive against the O. gallopavum reference system. Three of the 20 O. gallopavum culture filtrate antigens produced 1 or 2 precipitin bands of nonidentity with the S. constrictum reference reagents. Both isolates of S. tschawytschae were nonreactive with the O. gallopavum and S. constrictum reference reagents. In addition, O. gallopavum differed from S. constrictum in the production of a reddish-brown diffusible pigment, growth up to 45°C and sensitivity to cycloheximide. Based on these physiological differences and little or no antigenic relatedness between O. gallopavum and S. constrictum, it is concluded that these 2 spp. should be retained as separate entities rather than be considered as varieties of a single species.
KW - antigens
KW - immunology
KW - taxonomy
KW - Ochroconis
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - antigenicity
KW - fungus
KW - Hyphomycetes
KW - immunogens
KW - Ochroconis gallopavum
KW - Scolecobasidium
KW - Scolecobasidium constrictum
KW - systematics
KW - Taxonomy and Evolution (ZZ380)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206309&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of deoxynivalenol (DON, vomitoxin) in wheat by high-performance liquid chromatography with photolysis and electrochemical detection (HPLC-hv-EC).
AU - Childress, W. L.
AU - Krull, I. S.
AU - Selavka, C. M.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 1990///
VL - 28
IS - 2
SP - 76
EP - 82
SN - 0021-9665
AD - Childress, W. L.: U.S. Food and Drug Administration, Winchester, Massachusetts 01890, USA.
N1 - Accession Number: 19901205990. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 23255-69-8, 23282-20-4, 51481-10-8. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Postharvest Research; Wheat, Barley & Triticale Abstracts
N2 - Improved sensitivity and selectivity for the detection of DON in grains, as well as for the related compounds nivalenol and fusarenon-X, was made possible by the use of HPLC with online, postcolumn photolysis and oxidative amperometric detection (HPLC-hv-EC). Conditions were optimized with respect to residence time in the photolytic reactor, applied potentials, mobile phase pH and chromatographic parameters for the separation of DON, nivalenol and fusarenon-X, and the technique was found to be linear over a range of 10 p.p.b.-2 p.p.m. with minimum detection limits of the order of 1-2 ng on-column (10-20 p.p.b). Since these compounds are not electroactive in the absence of photolysis, an additional mode of specificity is realized in addition to the chromatographic retention time and the dual-electrode response ratio. Some market samples of wheat naturally contaminated with DON were analysed by this method, and the results were in agreement with those obtained by HPLC-UV and TLC analyses of the same samples.
KW - biodeterioration
KW - contamination
KW - determination
KW - estimation
KW - Fusarenon-X
KW - liquid chromatography
KW - Mycotoxins
KW - Nivalenol
KW - trichothecenes
KW - Vomitoxin
KW - wheat
KW - USA
KW - Triticum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - deoxynivalenol
KW - fungal toxins
KW - United States of America
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901205990&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phaeohyphomycotic cyst caused by Tetraploa aristata.
AU - Markham, W. D.
AU - Key, R. D.
AU - Padhye, A. A.
AU - Ajello, L.
JO - Journal of Medical and Veterinary Mycology
JF - Journal of Medical and Veterinary Mycology
Y1 - 1990///
VL - 28
IS - 2
SP - 147
EP - 150
SN - 0268-1218
AD - Markham, W. D.: A. A. Padhye, Division of Mycotic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19901206508. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A case of phaeohyphomycotic cyst on the left knee of a 54-yr-old man caused by T. aristata is reported. Identification was based on the coloration and morphology of the fungus in tissue and the macro- and micro-morphological characteristics of the mould isolated from the cyst fluid. The patient fully recovered following total excision of the cyst.
KW - hosts
KW - infections
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Massarinaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungus
KW - Hyphomycetes
KW - mitosporic fungi
KW - Tetraploa
KW - Tetraploa aristata
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206508&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Avian penicilliosis caused by Penicillium griseofulvum in a captive toucanet.
AU - Aho, R.
AU - Westerling, B.
AU - Ajello, L.
AU - Padhye, A. A.
AU - Samson, R. A.
JO - Journal of Medical and Veterinary Mycology
JF - Journal of Medical and Veterinary Mycology
Y1 - 1990///
VL - 28
IS - 5
SP - 349
EP - 354
SN - 0268-1218
AD - Aho, R.: A. A. Padhye, Division of Mycotic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19911207906. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology; Veterinary Science
N2 - A sudden fatal illness developed in a group of New World toucanets (Ramphastidae) held captive in Finland. Necropsy studies on one of the birds revealed the presence of invasive, hyaline, septate, branched mycelium in the lungs, air sacs, liver and other tissues. In addition, conidiophores and conidial chains, typical of members of the genus Penicillium were present in the lungs and air sacs. Cultures yielded a mould which was subsequently identified as P. griseofulvum. A critical review of the literature revealed that only 7 other species of Penicillium have been documented as agents of penicilliosis on the basis of histological and cultural findings.
KW - Aviary birds
KW - Case reports
KW - generalized infections
KW - hosts
KW - infections
KW - Mycoses
KW - Pathology
KW - zoo animals
KW - Finland
KW - birds
KW - Penicillium
KW - Penicillium griseofulvum
KW - Ramphastidae
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Penicillium
KW - Piciformes
KW - birds
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Scandinavia
KW - Northern Europe
KW - Europe
KW - cage birds
KW - fungus
KW - Hyphomycetes
KW - Zoo Animals (LL080)
KW - Pets and Companion Animals (LL070)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911207906&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Enhanced metabolic activation of aflatoxin B1 in dehydroepiandrosterone treated human fibroblast cells.
AU - Prasanna, H. R.
AU - Lu, M. H.
AU - Nakamura, K. D.
AU - Hart, R. W.
T2 - Proceedings - Annual Meeting of the American Association for Cancer Research
JO - Proceedings - Annual Meeting of the American Association for Cancer Research
JF - Proceedings - Annual Meeting of the American Association for Cancer Research
Y1 - 1990///
VL - 31
SP - 160
EP - 160
AD - Prasanna, H. R.: Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901206485. Language: English. Subject Subsets: Medical & Veterinary Mycology
N2 - The influence of dehydroepiandrosterone (DHEA), an adrenal steroid and an anticarcinogen, on the growth, subcellular constituents and the metabolism of aflatoxin B1 in human fibroblast cell cultures was investigated. At all concn tested (0-250 µM DHEA) there was a significant increase in the mean cellular volume, protein content and glutathione transferase activity (2-3 fold) in DHEA treated cells. Twenty-four hours after AFB1 treatment, higher amounts of AFB1 was bound to TCA precipitable proteins of the steroid treated cells (2933 vs 1540 fmols AFB1 bound per total protein from 106 cells) and more AFB1 derived water soluble metabolites were excreted into the media of the steroid treated cells (13 400 vs 5500 fmols/106 cells). It is concluded that DHEA mimics some of its hepatic effects in human fibroblast in culture and that this model can be utilized to further delineate the mechanistic aspects of the action of DHEA.
KW - Aflatoxins
KW - Mycotoxins
KW - steroids
KW - activation
KW - fungal toxins
KW - Plant Composition (FF040)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206485&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins as potential occupational hazards.
AU - Sorenson, W. G.
JO - Developments in Industrial Microbiology
JF - Developments in Industrial Microbiology
Y1 - 1990///
VL - 31
SP - 205
EP - 211
AD - Sorenson, W. G.: Immunology Section, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19911208678. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Mycotoxins as potential occupational hazards, including hypersensitivity, toxic volatile compounds of fungi, occurrence of aflatoxin in workplace aerosols, occurrence of mycotoxins in fungal spores and effects of mycotoxins in the lungs, are discussed.
KW - Aflatoxins
KW - health hazards
KW - Mycotoxins
KW - Occupational disorders
KW - fungal toxins
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208678&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid-chromatographic measurement of biopterin and neopterin in serum and urine.
AU - Slazyk, W. E.
AU - Spierto, F. W.
JO - Clinical Chemistry
JF - Clinical Chemistry
Y1 - 1990///
VL - 36
IS - 7
SP - 1364
EP - 1368
SN - 0009-9147
AD - Slazyk, W. E.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19911432554. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 22150-76-1. Subject Subsets: Human Nutrition
N2 - Serum and urine samples were acidified, treated with iodine in 0.2 mol/litre trichloroacetic acid, partly purified on Bio-Rad MP50 cation-exchange columns and analysed by reverse-phase high-performance liquid chromatography with fluorometric detection. The lowest concentration of biopterin detectable was 0.3 µg/litre in a 50-µl injection. The total coefficient of variation was up to 10%. Mean observed values for biopterin and neopterin in serum of normal adult human blood were 1.64 and 5.52 µg/litre, respectively. The mean ratio of neopterin to biopterin in acidified adult urine samples was lower than that in matched non-acidified samples.
KW - Biopterin
KW - blood
KW - Coenzymes
KW - estimation
KW - urine
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911432554&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fenitrothion-deltamethrin cross-resistance conferred by esterases in Guatemalan Anopheles albimanus.
AU - Brogdon, W. G.
AU - Barber, A. M.
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
Y1 - 1990///
VL - 37
IS - 2
SP - 130
EP - 139
SN - 0048-3575
AD - Brogdon, W. G.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920503260. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 52918-63-5, 122-14-5. Subject Subsets: Medical & Veterinary Entomology
N2 - Biochemical tests and bioassays showed elevated nonspecific esterase activity to cause fenitrothion-deltamethrin cross-resistance in Guatemalan A. albimanus adults and larvae. Resistance to both insecticides was nearly abolished by a specific esterase inhibitor (DEF). PAGE revealed an intensely staining esterase zone in all resistant mosquitoes, but in none of the susceptibles. All individuals surviving exposure to each of the 2 insecticides possessed this esterase zone. Mosquitoes with elevated esterase activity in microplate assays were those possessing the intensely staining zone. Isoelectric focusing electrophoresis resolved the zone into a series of bands, with elevated activity in resistant individuals. Densitometric measurements of the esterase zone on PAGE minigels suggested that elevated levels of these esterases might be the product of an amplified gene. Electrofocusing gels, chromatofocusing, and HPLC allowed estimates of nondenatured molecular weight (60 000) and pI (4.6). The resistance esterase activity showed some characteristics of B-esterases.
KW - Bioassays
KW - cross resistance
KW - Deltamethrin
KW - Enzyme inhibitors
KW - Enzymes
KW - Esterases
KW - Fenitrothion
KW - Insecticide resistance
KW - insecticides
KW - Organophosphorus insecticides
KW - Pyrethroids
KW - resistance
KW - Resistance mechanisms
KW - Central America
KW - Guatemala
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - mosquitoes
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticide and Drug Resistance (HH410)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920503260&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiology of free-living ameba infections.
AU - Visvesvara, G. S.
AU - Stehr-Green, J. K.
JO - Journal of Protozoology
JF - Journal of Protozoology
Y1 - 1990///
VL - 37
IS - 4
SP - 25S
EP - 33S
AD - Visvesvara, G. S.: Division of Parasitic Diseases and Division of HIV/AIDS, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910868929. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 78 ref. Subject Subsets: Protozoology; Public Health
N2 - Small free-living amoebae belonging to the genera Acanthamoeba and Naegleria occur world-wide. They have been isolated from a variety of habitats including fresh water, thermal discharges of power plants, soil, sewage and also from the nose and throats of patients with respiratory illness as well as healthy persons. Although the true incidence of human infections with these amoebas is not known, it is believed that as many as 200 cases of central nervous system infections due to these amoebas have occurred worldwide. A majority (144) of these cases have been due to Naegleria fowleri which causes an acute, fulminating disease, primary amoebic meningoencephalitis. The remaining 56 cases have been reported as being due either to Acanthamoeba or some other free-living amoeba which causes a subacute and/or chronic infection called granulomatous amoebic encephalitis (GAE). Acanthamoeba, in addition to causing GAE, also causes nonfatal, but nevertheless painful, vision-threatening infections of the human cornea, Acanthamoeba keratitis. Infections due to Acanthamoeba have also been reported in a variety of animals. These observations, together with the fact that Acanthamoeba spp., N. fowleri, and Hartmannella sp. can harbour pathogenic microorganisms such as Legionella and or mycobacteria indicate the public health importance of these amoebas.<new para>ADDITIONAL ABSTRACT:<new para>The reviewers analyse in particular the 93 cases of primary amoebic meningoencephalitis and granulomatous amoebic encephalitis that have been reported from the USA up to January 1990 (out of 200 cases worldwide). They also provide a map showing the distribution of cases of Acanthamoeba keratitis in the USA.Carolyn A. Brown
KW - amoebae
KW - amoebic primary meningoencephalitis
KW - epidemiology
KW - eye diseases
KW - Human diseases
KW - infections
KW - keratitis
KW - Meningoencephalitis
KW - parasites
KW - protozoal infections
KW - North America
KW - USA
KW - Acanthamoeba
KW - man
KW - Naegleria
KW - Naegleria fowleri
KW - protozoa
KW - Sarcomastigophora
KW - Acanthamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Vahlkampfiidae
KW - Schizopyrenida
KW - Naegleria
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - amebic primary meningoencephalitis
KW - America (North)
KW - prevalence
KW - protozoal diseases
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910868929&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Marking snails with numbered, colored discs: a technique for identifying individual specimens.
AU - Sullivan, J. J.
AU - Bishop, H. S.
AU - Schneider, K. R.
AU - Rodrick, G. E.
JO - Tropical Medicine and Parasitology
JF - Tropical Medicine and Parasitology
Y1 - 1990///
VL - 41
IS - 3
SP - 289
EP - 290
SN - 0177-2392
AD - Sullivan, J. J.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900868001. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Helminthology; Tropical Diseases
N2 - Numbered, coloured discs, measuring 2.5 mm in diameter, were evaluated under laboratory conditions, as tags for marking and identifying individual snails. Discs were affixed to the shells of specimens of Helisoma duryi (Pulmonata: Planorbidae), competitors of schistosome vector snails, with an adhesive supplied with the discs and with waterproof epoxy. All snails survived the initial tagging procedure and showed no observable behavioural responses to the tagging. The supplied adhesive, intended for use with terrestrial insects, was inadequate for securing the tags for prolonged periods under aquatic conditions. Use of waterproof epoxy, however, resulted in 100% tag retention for over 5 months without significant mortality. The permanence of the marks, their coding of individuals, the rapidity and ease with which the tags can be applied without causing behavioural changes or snail mortality, suggest that this technique will be useful in studies requiring identification of individual aquatic snails.<new para>ADDITIONAL ABSTRACT:<new para>Numbered (1-99) and coloured (5 colours) discs, 2.5 mm in diameter, are available commercially in Germany for the beekeeping industry. The discs were attached to shells of Helisoma duryi snails, at the centre of the outer whorl, the snails then being kept under laboratory conditions to test the durability of this method of tagging. Although the adhesive supplied with the discs was inadequate for disc retention in water, a waterproof epoxy kept the discs in place, on all snails tested, for over 5 months. This method of identifying individual aquatic snails is stated to be reliable, easy and quick to perform, and does not cause snail death or behavioural changes.Carolyn A. Brown
KW - helminths
KW - identification
KW - Intermediate hosts
KW - parasites
KW - Techniques
KW - Gastropoda
KW - Mollusca
KW - Planorbella duryi
KW - Mollusca
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Helisoma
KW - Planorbidae
KW - Gastropoda
KW - snails
KW - aquatic animals
KW - aquatic organisms
KW - Planorbella
KW - Helisoma duryi
KW - marking technique
KW - parasitic worms
KW - secondary hosts
KW - Techniques and Methodology (ZZ900)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900868001&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini).
AU - Piesman, J.
AU - Oliver, J. R.
AU - Sinsky, R. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1990///
VL - 42
IS - 4
SP - 352
EP - 357
SN - 0002-9637
AD - Piesman, J.: Division of Vector-borne Infectious Diseases, Public Health Service, Centers for Disease Control, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19900500213. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Borrelia burgdorferi multiplies rapidly in larvae of I. dammini, reaching a mean density of 2735 spirochaetes/tick on day 15 post-repletion. A 5-fold drop in spirochaete level occurred during the subsequent premoulting period. Recently moulted nymphs contained a mean of <300 spirochaetes/tick. Following nymphal repletion, spirochaete multiplication renewed, reaching a mean abundance of 61 275 spirochaetes/nymph on day 75 post-repletion. A 10-fold drop in spirochaete abundance occurred again when ticks moulted to the adult stage. Tick-derived spirochaetes proved to be infectious when >104 spirochaetes were inoculated ip into hamsters (4 of 4 animals infected). Inocula of 103-4 spirochaetes were not always infectious (8 of 23 animals infected), and inocula of <10³ spirochaetes were insufficient for establishing infection (0 of 8 animals infected).
KW - Development
KW - disease vectors
KW - infections
KW - Laboratory animals
KW - Lyme disease
KW - vectors
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Hamsters
KW - Ixodes
KW - Ixodes scapularis
KW - Ixodidae
KW - Metastigmata
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - bacterium
KW - growth kinetics
KW - Ixodes dammini
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900500213&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Primary structure of the 25-kilodalton ookinete antigen from Plasmodium reichenowi.
AU - Lal, A. A.
AU - Goldman, I. F.
AU - Campbell, G. H.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1990///
VL - 43
IS - 1
SP - 143
EP - 145
SN - 0166-6851
AD - Lal, A. A.: Malaria Branch Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Public Health and Human Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910869885. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Protozoology
N2 - The nucleotide and predicted amino acid sequences of the 25 000 MW ookinete antigen gene from P. reichenowi (Prs25) are presented and compared with those of the P. falciparum 25 000 MW cysteine-rich ookinete surface antigen (Pfs25). There was structural similarity to the epidermal growth factor-like domains, conservation in position and spacing of cysteine residues, and conservation of putative glycosylation sites. There was 95% sequence homology at the nucleotide level. The differences in the 2 genes were restricted to a total of 24 codons, of which 10 changes were silent 3rd base substitutions.
KW - antigens
KW - genes
KW - Human diseases
KW - Molecular genetics
KW - ookinetes
KW - parasites
KW - surface antigens
KW - Apicomplexa
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - antigenicity
KW - biochemical genetics
KW - immunogens
KW - Plasmodium reichenowi
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The 1987 forest fire disaster in California: assessment of emergency room visits.
AU - Duclos, P.
AU - Sanderson, L. M.
AU - Lipsett, M.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 1990///
VL - 45
IS - 1
SP - 53
EP - 58
SN - 0003-9896
AD - Duclos, P.: Division of Environmental Hazards and Health Effects, Center for Environmental Health and Injury Control, Centers for Disease Control, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19950615748. Publication Type: Journal Article. Language: English. Number of References: 16 ref.
N2 - Results are given of a survey to determine the effects on public health of smoke generated by severe lightning-ignited fires that started in forests in California during 5 days from 30 August 1987.
KW - forest fires
KW - public health
KW - respiratory diseases
KW - smoke
KW - California
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - Forest Fires (KK130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950615748&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reference system for cholesterol measurements.
AU - Cooper, G. R.
AU - Myers, G. L.
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
Y1 - 1990///
VL - 50
IS - Suppl. 198
SP - 27
EP - 31
SN - 0036-5513
AD - Cooper, G. R.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19921444260. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 14 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - A reference system for cholesterol measurement is necessary to assure accuracy of cholesterol measurements by clinical, research and manufacturers' laboratories. Such a reference system is based on the collaboration of laboratory and clinical professionals, research groups, professional societies, government groups and manufacturers of diagnostic products. Essential components include a definitive method, a reference method and commutable reference materials that are accurately labelled and have long-term stability. A mechanism by which clinical, research and manufacturers' laboratories can establish traceability to the reference system is also needed. In the USA, the National Reference System for Cholesterol (NRS/CHOL) was organized as part of the National Reference System for the Clinical Laboratory. The major organizational components of the NRS/CHOL include the National Institute for Standards and Technology (NIST), the Centers for Disease Control (CDC), the Cholesterol Reference Network (CRMN), the College of American Pathologists (CAP), the AAB, regional reference programmes, and manufacturers of cholesterol diagnostic products. The NIST maintains an isotope dilution-mass spectrometer definitive method and distributes certified reference materials. The CDC maintains a modified Abell-Levy-Brodie-Kendall reference method and offers a CDC-National Heart, Lung and Blood Institute Lipid Standardization Program; the CRMN provides reference method analyses on specimens furnished by manufacturers and clinical or research laboratories; CAP, AAB and regional reference programmes provide proficiency testing or quality assurance programmes, or both; and manufacturers assure that results on diagnostic products are the same as those achieved when using fresh patient specimens and the NRS/CHOL reference method. The NRS/CHOL has contributed much to the success of clinical epidemiological and research and development investigations in coronary heart disease.
KW - blood
KW - Cholesterol
KW - estimation
KW - Germany
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - Laboratory measurements in lipid disorders
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444260&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trend changes in use and current intakes of tropical oils in the United States.
AU - Park, Y. K.
AU - Yetley, E. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1990///
VL - 51
IS - 5
SP - 738
EP - 748
SN - 0002-9165
AD - Park, Y. K.: Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901450711. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition
N2 - To evaluate the need for an potential public health impact of selective labelling of foods containing tropical oils (TO), trend changes in use of TO in the USA from 1963 to 1985 were studied and current intakes of total fat (FI) and saturated fatty acids (SFAI) attributable to TO were estimated. Although world production of TO has increased rapidly since 1970, use in the USA has not followed the world trend. A large portion of TO in the USA was used in non-food products. Estimates of current intake of TO by selected US population groups revealed only minor contribution of TO to the daily FI and SFAI in the USA. In 1985 the most reasonable estimate of the average FI from all 3 TO represented less than 4% of total daily FI or less than 2% of daily energy intake. Three TO combined contributed 8% or less to the daily SFAI of the sex and age groups examined.
KW - Coconut oil
KW - intake
KW - Oils
KW - Palm kernel oil
KW - Palm oils
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
KW - Economics (General) (EE100) (Discontinued June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450711&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Real-time measurement and control of waste anesthetic gases during veterinary surgeries.
AU - Burkhart, J. E.
AU - Stobbe, T. J.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1990///
VL - 51
IS - 12
SP - 640
EP - 645
SN - 0002-8894
AD - Burkhart, J. E.: National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19912255206. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 151-67-7, 76-38-0. Subject Subsets: Veterinary Science; Veterinary Science; Public Health
N2 - A MIRAN IA infra-red spectrophotometer was used for exposure measurements of waste anaesthetic gases, primarily methoxyflurane and halothane, which were administered to animals at 0.4-1.0% and 0.5-1.2% respectively. During surgery a 1.27 cm inside diameter sampling tube from the MIRAN was held near the operator's breathing zone; the output signal was received by both a strip chart recorder and a data logger which encoded the signal for the computer for subsequent analysis. Surveys were conducted at 5 clinics, 3 using methoxyflurane and 2 halothane; none used scavengers. Time-weighted average concentrations were 0.5-45.5 and 0.2-105.4 ppm respectively. Examples of real-time measurement are depicted. Sources of waste gases were faulty technique (25%) and the unscavenged anaesthetic machine. Activated charcoal adsorption is advocated for control in veterinary clinics, which may operate in several locations; at least 95% reduction was provided. A computer model was designed to determine optimum specifications.<new para>ADDITIONAL ABSTRACT:<new para>Waste anaesthetic gas exposures were determined using a modified MIRAN 1A spectrophotometer at 5 veterinary clinics. For unscavenged systems of methoxyflurane and halothane, 1-h time-weighted average exposures ranged from 0.5 to 45.5 and from 0.2 to 105.4 p.p.m., respectively. From analysis of strip chart recorder tracing and personal observation, the source of waste anaesthetic gases were identified as poor work practices (up to 25%) and the unscavenged gas cart (>75%). A method is described using activated charcoal adsorption for controlling anaesthetic gas exposures during surgical operations. The scavenging system consisted of an adsorption column containing 2.5 kg of charcoal, sufficient for 100 h of service life at a waste flow rate of 3 l/min. It was tested by attaching it to a Vetroson Model 6500 small animal anaesthetic machine using methoxyflurane.M.R. Hails
KW - Anaesthesia
KW - Anaesthetics
KW - gases
KW - Halothane
KW - health hazards
KW - inhaled anaesthetics
KW - measurement
KW - Methoxyflurane
KW - Occupational hazards
KW - occupational medicine
KW - occupations
KW - pollution
KW - sampling
KW - Spectrophotometry
KW - toxic substances
KW - Toxicology
KW - veterinarians
KW - veterinary practice
KW - Waste gases
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - America (North)
KW - anesthesia
KW - anesthetics
KW - environmental pollution
KW - inhaled anesthetics
KW - metrology
KW - poisons
KW - sampling techniques
KW - United States of America
KW - veterinary surgeons
KW - vets
KW - waste anaesthetic
KW - waste anaesthetic gas exposure
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Industrial Wastes and Effluents (XX400)
KW - Veterinary Profession (CC720) (Discontinued March 2000)
KW - Pollution and Degradation (PP600)
KW - Occupational Health and Safety (VV900)
KW - Animal Health and Hygiene (General) (LL800)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912255206&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of vitamin A toxicity.
AU - Hathcock, J. N.
AU - Hattan, D. G.
AU - Jenkins, M. Y.
AU - McDonald, J. T.
AU - Sundaresan, P. R.
AU - Wilkening, V. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1990///
VL - 52
IS - 2
SP - 183
EP - 202
SN - 0002-9165
AD - Hathcock, J. N.: Food and Drug Administration, HFF-268, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901452697. Publication Type: Journal Article. Language: English. Number of References: 224 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition
N2 - Toxicity has been associated with abuse of vitamin A supplements and with diets extremely high in preformed vitamin A. Consumption of 25 000 to 50 000 IU daily for periods of several months or more can produce multiple adverse effects. The lowest reported intakes causing toxicity have occurred in persons with liver function compromised by drugs, viral hepatitis or protein-energy malnutrition. Certain drugs or other chemicals may markedly potentiate vitamin A toxicity in animals. Especially vulnerable groups include children with adverse effects occurring with intakes as low as 1500 IU/kg daily, and pregnant women, with birth defects being associated with maternal intakes as low as about 25 000 IU daily. The maternal dose threshold for birth defects cannot be identified from present data. An identifiable fraction of the population surveyed consumes vitamin A supplements at 25 000 IU daily and a few persons consume much more. β-Carotene is much less toxic than vitamin A.
KW - Retinol
KW - reviews
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452697&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relationship between age and serum vitamin A in children aged 4-11 y.
AU - Lewis, C. J.
AU - McDowell, M. A.
AU - Sempos, C. T.
AU - Lewis, K. C.
AU - Yetley, E. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1990///
VL - 52
IS - 2
SP - 353
EP - 360
SN - 0002-9165
AD - Lewis, C. J.: Food and Drug Administration, HFF-265, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19901452747. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 68-26-8. Subject Subsets: Human Nutrition
N2 - The association between age and serum vitamin A concentrations in children was examined by using total serum vitamin A values from the second National Health and Nutrition Examination Survey (NHANES II) and serum retinol values for Mexican Americans from the Hispanic HANES. Analyses included multivariate strategies to identify confounders of serum vitamin A. After the effect of the use of vitamin-mineral supplements on total serum vitamin A values was controlled for, the results indicated that younger children (4 to 5 years old) have lower serum vitamin A concentrations than do older children (9 to 11 years old) regardless of whether the measure was total serum vitamin A or serum retinol. This relation was systematic across the distribution of values and suggested that the difference may be due to normal physiological events. A different interpretive criterion may be needed for younger and older children when serum vitamin A is used to indicate vitamin A state.
KW - age
KW - blood
KW - Children
KW - retinol
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901452747&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evidence for a secular change in obesity, height and weight among Navajo Indian schoolchildren.
AU - Sugarman, J. R.
AU - White, L. L.
AU - Gilbert, T. J.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1990///
VL - 52
IS - 6
SP - 960
EP - 966
SN - 0002-9165
AD - Sugarman, J. R.: Shiprock Public Health Service Hospital, PO Box 160, Shiprock, NM 87420, USA.
N1 - Accession Number: 19911434682. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
N2 - The results from a survey measuring heights and weights of 1969 school children residing on the Navajo Indian Reservation in 1989, were compared with National Center for Health Statistics (NCHS) reference data and with surveys of Navajo children from 1955, 1968 and 1981. About twice as many children exceeded the 95th percentile of weight-for-age (11.2% of girls, 12.5% of boys) than would be expected for the NCHS reference population. The mean weight-for-height z scores exceeded those for the NCHS reference population for all ages in both sexes. Compared with data from 1955, mean heights increased 6.1% among boys and 4.4% among girls, whereas mean weights increased 28.8% among boys and 18.7% among girls across all age groups. The data suggest that there has been a secular change in height, weight, and obesity in Navajo Indian children over the past 35 years.
KW - body measurements
KW - children
KW - ethnic groups
KW - School children
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - school kids
KW - schoolchildren
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911434682&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recovery of heat-stressed Listeria monocytogenes from experimentally and naturally contaminated shrimp.
AU - McCarthy, S. A.
AU - Motes, M. L.
AU - McPhearson, R. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1990///
VL - 53
IS - 1
SP - 22
EP - 24
SN - 0362-028X
AD - McCarthy, S. A.: Fishery Research Branch, Food and Drug Administration, Dauphin Island, AL 36529, USA.
N1 - Accession Number: 19901359596. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - A method was developed to enhance recovery of thermally stressed L. monocytogenes from internally contaminated shrimp. Shrimp tail meat was inoculated with 105L. monocytogenes cells/g and boiled for 1-5 min. Thermally stressed L. monocytogenes cells were recovered following cold enrichment for 3 d without broth. Methods of the FDA and the USDA for isolating L. monocytogenes permitted recovery of the organism from shrimp boiled for 1 min; however, with the new method, L. monocytogenes cells were recovered from shrimp boiled up to 5 min. No Listeria spp. were recovered from naturally contaminated, frozen, imported shrimp after 1 min boiling.
KW - biodeterioration
KW - Heat resistance
KW - pathogens
KW - Shrimps
KW - survival
KW - Listeria monocytogenes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Environmental Tolerance of Plants (FF900)
KW - Biodeterioration (SS300)
KW - Aquatic Biology and Ecology (MM300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Aquatic Produce (QQ060)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901359596&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sodium hypophosphite inhibition of the growth of selected gram negative foodborne pathogenic and spoilage bacteria.
AU - Rhodehamel, E. J.
AU - Pierson, M. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1990///
VL - 53
IS - 1
SP - 56
EP - 63
SN - 0362-028X
AD - Rhodehamel, E. J.: Food and Drug Administration, Division of Microbiology, 200 C Street S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19901359598. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - All inhibition studies were performed with opt. or nearly opt. growth conditions for each bacterium. Growth was monitored by measuring optical density at 600 nm, and a time to significant growth determined in each test medium. Ratios of time to significant growth in controls over that in test media were used to evaluate the effect that sodium hypophosphite and other variables had on growth. Sodium hypophosphite was most effective in inhibiting growth of Gram negative facultatively anaerobic bacteria, but generally ineffective against the aerobic Pseudomonas fluorescens and microaerophilic Campylobacter jejuni strs H-840 and Smith. Results from this investigation indicate the potential use of sodium hypophosphite as an antimicrobial food preservative.
KW - biodeterioration
KW - control
KW - Gram negative bacteria
KW - pathogens
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Gram-negative bacteria
KW - Sodium hypophosphite
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Food Storage and Preservation (QQ110)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901359598&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative depletion of sulfamethazine in bob veal, fancy veal and replacement calves.
AU - Barnes, C. J.
AU - Guyer, C. C.
AU - Geleta, J. V.
AU - Matusik, J. E.
AU - Weber, J. D.
AU - Frank, L. R.
AU - Morris, G. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1990///
VL - 53
IS - 2
SP - 154
EP - 157
SN - 0362-028X
AD - Barnes, C. J.: Center for Veterinary Medicine, Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA.
N1 - Accession Number: 19912253044. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 57-68-1. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Veterinary Science
N2 - The sulfamethazine (sulfadimidine) depletion rate was compared in 12 Holstein bull calves reared to produce bob veal, fancy veal and in replacement calves, to see if the required tolerance of 0.1 ppm or less was reached 10 days after withdrawal. Calves were treated with sulfadimidine once at 220 mg/kg as oblets given orally then at 100 mg/kg for 4 days at the following ages, bob veal 3-5 days, fancy veal and replacement calves at 12-13 weeks. Using withdrawal periods of 1, 3, 5, 7, 10 and 14 days, sulfadimidine and its metabolites N4-acetylsulfamethazine and desaminosulfamethazine were measured in liver, kidney and diaphragm muscle by gas chromatography. Blood samples collected before and after dosing and after slaughter gave variable results. There were no significant differences in the level of sulfadimidine in muscle samples from the diaphragm, thigh, loin and shoulder, nor in blood plasma of male and female calves. Average sulfadimidine concn. on day 5 in liver, kidney and diaphragm were 1 mg/kg in fancy veal, > 2 mg/kg in bob veal and < 0.10 mg/kg in replacement veal. After 10 days, sulfadimidine residues (mg/kg) were detected in liver as follows: bob veal at 10 days, 0.13; fancy veal at 10 days, 0.24 and 0.11, and at 14 days, 0.15 and 0.12 N4-acetylsulfamethazine and desaminosulfamethazine were not detected accurately, but the former was found at 3-80% of sulfadimidine levels. It was concluded that 10 days withdrawal from sulfadimidine is not long enough for bob and fancy veal calves.
KW - calves
KW - Drug residues
KW - Meat hygiene
KW - residues
KW - Sulfadimidine
KW - Sulfonamides
KW - sulfamethazine
KW - sulphadimidine
KW - sulphonamides
KW - withdrawal period
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912253044&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enumeration of Vibrio species, including V. cholerae, from samples of an oyster growing area, Grays Harbor, Washington.
AU - Kaysner, C. A.
AU - Abeyta, C., Jr.
AU - Stott, R. F.
AU - Krane, M. H.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1990///
VL - 53
IS - 4
SP - 300
EP - 301, 311
SN - 0362-028X
AD - Kaysner, C. A.: Food and Drug Administration, Seafood Products Research Center, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19901361132. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - Water, shellfish and sediment samples from Grays Harbor, a major commercial oyster producing estuary in the State of Washington, were examined for levels of Vibrio spp. Non-01 V. cholerae was found at low levels in 37.8% of the samples. While V. parahaemolyticus was found in all samples, levels were low. V. mimicus and V. fluvialis were found infrequently and at low levels. Potentially pathogenic strs of non-01 V. cholerae and Kanagawa positive V. parahaemolyticus were isolated from oysters suggesting a potential for human illness.
KW - biodeterioration
KW - Oysters
KW - pathogens
KW - USA
KW - Washington
KW - Vibrio
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - bacterium
KW - United States of America
KW - Biodeterioration (SS300)
KW - Aquatic Biology and Ecology (MM300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Aquatic Produce (QQ060)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901361132&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth of Salmonella enteritidis in yolk of shell eggs from normal and seropositive hens.
AU - Bradshaw, J. G.
AU - Shah, D. B.
AU - Forney, E.
AU - Madden, J. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1990///
VL - 53
IS - 12
SP - 1033
EP - 1036
SN - 0362-028X
AD - Bradshaw, J. G.: D.B. Shah, Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19912251034. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Veterinary Science; Veterinary Science; Poultry
N2 - The growth of S. enteritidis inoculated into the yolks of shell eggs from normal and seropositive hens was determined at various temperatures. All eggs were inoculated with approximately 1 colony-forming unit (CFU)/g of yolk. In eggs from normal hens, the organism multiplied with a generation time of 25 min, reaching a density of about 108 CFU/g in 12 h at 37°C. A generation time of 3.5 h was observed in eggs incubated at 15.5°C, a temperature frequently used for commercial storage of eggs. Cell density of >107 CFU/g was reached in 4 days at 15.5°C. No multiplication was observed in eggs incubated at 7°C for 94 days. When inoculated eggs from seropositive birds were incubated at 37°C, the organism multiplied with a generation time of 35 min, reaching a cell density of >106 CFU/g in 12 h. Raw egg white was detrimental to cells, reducing cell viability 50% in 4 h at 37°C. The limulus amoebocyte lysate test gave a positive reaction with whole liquid egg containing <10³ CFU/g. A protocol is suggested for possible application of this test in epidemiological studies that screen grade A shell eggs for Salmonella contamination.
KW - Bacterial diseases
KW - biodeterioration
KW - contamination
KW - egg shell
KW - Eggs
KW - pathogens
KW - poultry
KW - poultry diseases
KW - Public health
KW - Bacteria
KW - Salmonella enteritidis
KW - prokaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - domesticated birds
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Biodeterioration (SS300)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912251034&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Azoreductase activity of anaerobic bacteria isolated from human intestinal microflora.
AU - Rafii, F.
AU - Franklin, W.
AU - Cerniglia, C. E.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1990///
VL - 56
IS - 7
SP - 2146
EP - 2151
SN - 0099-2240
AD - Rafii, F.: C. E. Cerniglia, Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19911428809. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - A plate assay was developed for the detection of anaerobic bacteria that produce azoreductases. With this plate assay, 10 strains of anaerobic bacteria capable of reducing azo dyes were isolated from human faeces and identified as Eubacterium hadrum (2 strains), Eubacterium spp. (2 species), Clostridium clostridiiforme, a Butyrivibrio sp., a Bacteroides sp., Clostridium paraputrificum, Clostridium nexile and a Clostridium sp. The average rate of reduction of Direct Blue 15 dye (a dimethoxybenzidine-based dye) in these strains ranged from 16 to 135 nmol dye/ min-1 mg protein-1. The enzymes were inactivated by oxygen. In 7 isolates, a flavin compound (riboflavin, flavin adenine dinucleotide or flavin mononucleotide) was required for azoreductase activity. In the other 3 isolates and in Clostridium perfringens, no added flavin was required for activity. Non-denaturing polyacrylamide gel electrophoresis showed that each bacterium expressed only one azoreductase isozyme. At least 3 types of azoreductase enzyme were produced by the different isolates. All of the azoreductases were produced constitutively and released extracellularly.
KW - azo compounds
KW - Intestines
KW - reduction
KW - bacteria
KW - Man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Human Physiology and Biochemistry (VV050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Replica plating of colonies from Listeria-selective agars to blood agar to improve the isolation of Listeria monocytogenes from foods.
AU - Cassiday, P. K.
AU - Graves, L. M.
AU - Swaminathan, B.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1990///
VL - 56
IS - 7
SP - 2274
EP - 2275
SN - 0099-2240
AD - Cassiday, P. K.: B. Swaminathan, Meningitis and Special Pathogens Branch, Division of Bacterial Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900441442. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Dairy Science; Public Health
N2 - Bacterial colonies from Listeria-selective agars were replica plated onto sheep blood agar to screen for β-haemolysis. By using the replica plating method to test for the β-haemolytic characteristic of all the colonies growing on Listeria-selective agars instead of picking 3 to 10 suspected colonies for further testing, the authors recovered Listeria monocytogenes from 59 of 142 Listeria-selective agar plates that contained colonies of haemolytic and non-haemolytic Listeria species, and were negative when tested by conventional colony picks.<new para>ADDITIONAL ABSTRACT:<new para>Bacterial colonies from Listeria-selective agars were replica plated to sheep blood agar to screen for beta-hemolysis. By using the replica plating method to test for the beta-hemolytic characteristic of all the colonies growing on Listeria-selective agars instead of picking 3 to 10 suspected colonies for further testing, [the authors] recovered Listeria monocytogenes from 59 of 142 Listeria-selective agar plates which contained colonies of hemolytic and nonhemolytic Listeria species and were negative when tested by conventional colony picks.AS
KW - biodeterioration
KW - comparisons
KW - Culture media
KW - culture techniques
KW - food
KW - foods
KW - isolation
KW - pathogens
KW - Techniques
KW - Listeria
KW - Listeria monocytogenes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Microbiology (General) (ZZ390)
KW - Milk and Dairy Produce (QQ010)
KW - Microbial Technology in Food Processing (QQ120)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermotolerance of Listeria monocytogenes and Salmonella typhimurium after sublethal heat shock.
AU - Bunning, V. K.
AU - Crawford, R. G.
AU - Tierney, J. T.
AU - Peeler, J. T.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1990///
VL - 56
IS - 10
SP - 3216
EP - 3219
SN - 0099-2240
AD - Bunning, V. K.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19920450049. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Dairy Science; Public Health
N2 - The effect of prior heat shock on thermotolerance of Listeria monocytogenes and Salmonella typhimurium in broth culture was determined. Bacteria were grown at the permissive temp. of 35°C, sublethally heated at 35 (control), 42, 48 and 52°C (non-permissive control) for various times, and inactivated at either 57.8 or 52°C. The induction of increased thermotolerance by heat shock, although consistent within each experiment, was generally not significant for L. monocytogenes; the increase was significant for S. typhimurium. Temp.-shift experiments with L. monocytogenes suggested that induced thermotolerance was not long lived unless the shock temp. was maintained.
KW - biodeterioration
KW - heat stress
KW - heat tolerance
KW - heat treatment
KW - pathogens
KW - survival
KW - Listeria monocytogenes
KW - Salmonella typhimurium
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - bacterium
KW - heat processing
KW - thermotolerance
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Microbiology (General) (ZZ390)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sporotrichosis - an occupational hazard for nursery workers, tree planters and orchid growers.
AU - Padhye, A. A.
AU - Ajello, L.
JO - American Orchid Society Bulletin
JF - American Orchid Society Bulletin
Y1 - 1990///
VL - 59
IS - 6
SP - 613
EP - 616
SN - 0003-0252
AD - Padhye, A. A.: Division of Mycotic Diseases, Centre for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19901206849. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Sporothrix schenckii infection, including its various forms and their most common symptoms, diagnosis, causal agent, geographical distribution, natural habitat, protective measures and control, and treatment, is discussed as an occupational hazard for nursery workers, tree planters and orchid growers.
KW - infections
KW - Occupational disorders
KW - occupations
KW - predisposition
KW - Man
KW - Sporothrix schenckii
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sporothrix
KW - Ophiostomataceae
KW - Ophiostomatales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - fungus
KW - Hyphomycetes
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of EDTA on the bioavailability to rats of fortification iron used in Egyptian balady bread.
AU - Whittaker, P.
AU - Vanderveen, J. E.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 1990///
VL - 63
IS - 3
SP - 587
EP - 595
SN - 0007-1145
AD - Whittaker, P.: Food and Drug Administration, Division of Nutrition, 200 C Street, SW (HFF-268), Washington, DC 20204, USA.
N1 - Accession Number: 19901450954. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 60-00-4, 7439-89-6. Subject Subsets: Human Nutrition
N2 - The effectiveness of EDTA compounds on iron fortificants for potential use in Egyptian balady bread was tested in 60 Sprague-Dawley weanling male rats by the haemoglobin regeneration efficiency (HRE) method. To confirm HRE-derived findings, 8 groups of 10 rats were repleted with a modified American Institute of Nutrition (1977; AIN) 76A diet, fortified with ferric phosphate, electrolytic Fe, carbonyl Fe or ferrous sulphate, with and without ascorbic acid. Results without ascorbic acid were comparable to findings of a human study by Forbes et al. [American Journal of Clinical Nutrition (1989) 49, 225]. Bioavailability of EDTA-enhanced fortificants, FeSO4 + NA2EDTA and NaFe(III)EDTA, was compared with that of FeSO4 in 6 groups of 10 rats repleted with a ground Egyptian bread meal or a casein-based AIN diet fortified with 1 of the 3 compounds. Addition of either EDTA compound significantly increased bioavailability of Fe in Egyptian balady bread. When present in the less inhibitory casein meal, however, FeSO4 + Na2EDTA fortification was significantly less effective than NaFe(III)EDTA or the reference FeSO4. Results indicate that NaFe(III)EDTA may be the fortificant of choice in a mixed diet. Further study of EDTA-enhanced Fe fortificants is needed.
KW - availability
KW - bread
KW - EDTA
KW - fortification
KW - iron
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - edetic acid
KW - ethylenediaminetetraacetic acid
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemoprophylactic drug trials for treatment of dracunculiasis using the Dracunculus insignis-ferret model.
AU - Eberhard, M. L.
AU - Brandt, F. H.
AU - Ruiz-Tiben, E.
AU - Hightower, A.
JO - Journal of Helminthology
JF - Journal of Helminthology
Y1 - 1990///
VL - 64
IS - 2
SP - 79
EP - 86
SN - 0022-149X
AD - Eberhard, M. L.: WHO Collaborating Center for Research, Training and Control of Dracunculiasis, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900866159. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 52-68-6, 54965-21-8, 90-89-1, 1642-54-2, 70288-86-7. Subject Subsets: Helminthology; Tropical Diseases
N2 - Groups of ferrets inoculated with D. insignis were treated with various anthelmintic compounds to evaluate the potential use of drugs in controlling D. medinensis. The 3 primary compounds tested were diethylcarbamazine (DEC), albendazole, and ivermectin; they were administered in dosages of 60 mg/kg, 10 mg/kg, and 1 mg/kg, respectively. Groups of animals received treatment either once at 60 days after inoculation, once at 60 and 90 days, or for 3 days at either 60 or 90 days postinoculation. The most marked decrease occurred in the animals that received treatment once at 60 and at 90 days after inoculation. This was observed for all 3 drugs tested. Increased dosages, i.e., 3 days of treatment at 60 or 90 days did not result in decreased worm burdens. In no group was there a statistically significant reduction in worm burden when compared with controls. Two other compounds, metrifonate [trichlorfon] and CGP 6140 [amocarcine], were tested in a more limited manner, but again the worm recovery rates were comparable with those in control groups. It would appear that existing drugs commonly used to treat helminthic infections are poor candidates for use in the campaign to eradicate guinea worm disease.<new para>ADDITIONAL ABSTRACT:<new para>Ferrets treated with up to 3 doses of diethylcarbamazine, albendazole or ivermectin, at various times after their inoculation with Dracunculus insignis, yielded worm burdens that were not significantly different from those recovered from untreated inoculated ferrets. Metriphonate and CGP6140 in more limited trials were also ineffective in reducing worm recovery. The authors conclude that these agents commonly used for other helminthic infections do not appear promising for the control of human guinea-worm infection, at least as shown in this model.Carolyn A. Brown
KW - albendazole
KW - Anthelmintics
KW - diethylcarbamazine
KW - Disease models
KW - dracunculiasis
KW - DRUG THERAPY
KW - helminths
KW - Human diseases
KW - ivermectin
KW - Laboratory animals
KW - parasites
KW - treatment
KW - trichlorfon
KW - Carnivores
KW - Dracunculus insignis
KW - ferrets
KW - Nematoda
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Dracunculus
KW - Dracunculidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - amocarcine
KW - CGP 6140
KW - chemotherapy
KW - chlorofos
KW - chlorophos
KW - dracontiasis
KW - guinea worm disease
KW - guinea worm infection
KW - metrifonate
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - trichlorphon
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological observations on Chrysomya megacephala (Fabr.) (Diptera: Calliphoridae) in Los Angeles, California and the Palau Islands.
AU - Olsen, A. R.
AU - Sidebottom, T. H.
JO - Pan-Pacific Entomologist
JF - Pan-Pacific Entomologist
Y1 - 1990///
VL - 66
IS - 2
SP - 126
EP - 130
SN - 0031-0603
AD - Olsen, A. R.: US Food and Drug Administration, 1521 W. Pico Blvd., Los Angeles, CA 90015, USA.
N1 - Accession Number: 19920505985. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Horticultural Science; Medical & Veterinary Entomology
N2 - In 1988 and 1989, specimens of C. megacephala were collected in urban Los Angeles, California, USA. It was evident in summer to autumn 1988, and reappeared in summer 1989 [see also R.V. Dowell & R. Gill (1989) Pan-Pacific Entomologist, 65: 132-145 (1989)]. Earlier collections and observations of C. megacephala were recorded in 1986 in the Palau Islands (Belau). In rural Palau, the males were rarely seen in inhabited areas except during dawn swarming activities, but in Los Angeles, the males were found in ornamental vegetation in the urban habitat. The origin of C. megacephala in California is unknown but may be via the Pacific Islands or Mexico.
KW - Behaviour
KW - distribution
KW - Ecology
KW - Geographical distribution
KW - Introduced species
KW - Urban areas
KW - California
KW - North America
KW - Oceania
KW - Palau
KW - Trust Territory of the Pacific Islands
KW - USA
KW - Calliphoridae
KW - Chrysomya megacephala
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Chrysomya
KW - Calliphoridae
KW - Caroline Islands
KW - Micronesia
KW - Oceania
KW - Pacific Islands
KW - Developing Countries
KW - islands
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American Oceania
KW - behavior
KW - Belau
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Pacific Islands Trust Territory
KW - United States of America
KW - Animal Behaviour (LL300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Study on iron bioavailability in a native Nigerian grain amaranth cereal for young children, using a rat model.
AU - Whittaker, P.
AU - Ologunde, M. O.
JO - Cereal Chemistry
JF - Cereal Chemistry
Y1 - 1990///
VL - 67
IS - 5
SP - 505
EP - 508
SN - 0009-0352
AD - Whittaker, P.: Division of Nutrition (HFF-268), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19911429975. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Anaemia was induced in male weanling Sprague-Dawley rats by bleeding and 7 days on a diet deficient in iron. They were then given 1 of 4 repletion diets based on Nigerian grain amaranth (Amaranthus caudatus). Three diets had Fe about 35 mg/kg added from sodium ferric EDTA (NaFeEDTA), ferrous fumarate (FeC4H2O4) or ferrous sulfate and the fourth had unfortified amaranth which contained 69 mg intrinsic Fe per kg diet. Haemoglobin gain in all 3 groups given fortified cereal was significantly greater than in those given unfortified cereal and was highest in those given FeC4H2O4. Relative biological values for rats given unfortified amaranth or cereal fortified with NaFeEDTA, FeC4H2O4 or FeSO4 were 0.78, 0.93, 1.05 and 1.00, respectively. Protein efficiency ratio of fortified amaranth was about 1.6 compared with 0.9 for Egyptian bread.
KW - availability
KW - iron
KW - Nigeria
KW - Amaranthus caudatus
KW - Man
KW - rats
KW - Amaranthus
KW - Amaranthaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Muridae
KW - rodents
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - Animal Models of Human Nutrition (VV140)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and semiquantitative estimation of chlorinated organic pesticide residues in foods by paper chromatography.
AU - Mills, P. A.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 1
SP - 4
EP - 11
AD - Mills, P. A.: Division of Food, Food and Drug Administration, Washington 25, DC, USA.
N1 - Accession Number: 19921451663. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - This is a reprint of a classic paper first published in the Journal of the Association of Official Analytical Chemists 42, 734-740 in 1959. It describes a general procedure applying various techniques of (1) solvent extraction, or "stripping:' (2) purification of the extracts, or "clean-up"; and (3) paper chromatography, which permitted rapid identification and approximate measurement of residual amounts of a number of commonly used pesticides in a variety of foods and feeds.
KW - analytical methods
KW - foods
KW - Pesticide residues
KW - analytical techniques
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total sulfite in shrimp, potatoes, dried pineapple, and white wine by flow injection analysis: collaborative study.
AU - Sullivan, J. J.
AU - Hollingworth, T. A.
AU - Wekell, M. M.
AU - Meo, V. A.
AU - Saba, H. H.
AU - Etemad-Moghadam, A.
AU - Eklund, C.
AU - Phillips, J. G.
AU - Gump, B. H.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 1
SP - 35
EP - 42
AD - Sullivan, J. J.: U.S. Food and Drug Administration, Seafood Products Research Center, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19921451664. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Horticultural Science; Human Nutrition; Potatoes
N2 - A method for the determination of total sulfite in shrimp, potatoes, dried pineapple and white wine by flow injection analysis (FIA) was collaboratively studied by 8 laboratories. The sample solution is reacted with sodium hydroxide to liberate aldehyde-bound sulfite. The sample stream is acidified to produce SO2 gas, which diffuses across a Teflon membrane in the gas diffusion cell into a flowing stream of malachite green. The degree of discoloration of the malachite green is proportional to the amount of sulfite in the sample solution. Red wine was included in the study but inter-laboratory precision was not satisfactory, correlation with Monier-Williams results was poor, therefore the present method is not recommended for use with these samples. For shrimp, potatoes, dried pineapple and white wine, average reproducibility (RSDR) of results was 25% for samples at SO2 10 mg/kg and 10% for samples at >50 mg/kg. Overall average reproducibility was 14%. Recoveries of sulfite added to samples averaged 80%. Comparison of FIA with the Monier-Williams method indicated comparable results by the 2 methods. The FIA method has been adopted official first action for determination of ≥5 mg/kg total sulfite in shrimp, potatoes, dried pineapple and white wine.
KW - analytical methods
KW - composition
KW - determination
KW - Food products
KW - foods
KW - Pineapples
KW - Plant composition
KW - Potatoes
KW - Shrimps
KW - Sulfites
KW - techniques
KW - Tubers
KW - Ananas comosus
KW - Solanum tuberosum
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Ananas
KW - Bromeliaceae
KW - Bromeliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - analytical techniques
KW - chemical constituents of plants
KW - sulphites
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for determination of aflatoxins B1, B2, G1, and G2 in corn and peanut products: collaborative study.
AU - Park, D. L.
AU - Nesheim, S.
AU - Trucksess, M. W.
AU - Stack, M. E.
AU - Newell, R. F.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 2
SP - 260
EP - 266
AD - Park, D. L.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19901206332. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology; Postharvest Research; Maize
N2 - A collaborative study of a liquid chromatographic method for the determination of aflatoxins B1, B2, G1 and G2 was conducted in laboratories located in the United States, Canada, South Africa and Switzerland. Twenty-one artificially contaminated raw groundnuts, groundnut butter and maize samples containing varying amounts of aflatoxins B1, B2, G1 and G2 were distributed to participating laboratories. The test portion was extracted with methanol-0.1N HCl (4+1), filtered, defatted with hexane and then partitioned with methylene chloride. The concentrated extract was passed through a silica gel column. Aflatoxins B1 and G1 were derivatized with trifluoroacetic acid and the individual aflatoxins were determined by reverse-phase liquid chromatography with fluorescence detection. Statistical analysis of the data was performed to determine or confirm outliers and to compute repeatability and reproducibility of the method. For maize, relative standard deviations for repeatability (RSDr) for aflatoxin B1 ranged from 27.2 to 8.3% for contamination levels from 5 to 50 ng/g. For raw groundnuts and groundnut butter, RSDr values for aflatoxin B1 were 35.0 to 41.2% and 11.2 to 19.1%, respectively, for contamination levels from 5 to 25 ng/g. RSDr values for aflatoxins B2, G1 and G2 were similar. Relative standard deviations for reproducibility (RSDR) for aflatoxin B1 ranged from 15.8 to 38.4%, 24.4 to 33.4% and 43.9 to 54.0% for maize, groundnut butter and raw groundnuts, respectively. It is reported that the method has been adopted official first action for the determination of aflatoxins B1, B2, G1 and G2 in groundnut butter and maize at concn ≥13 ng total aflatoxins/g.
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - determination
KW - estimation
KW - groundnut butter
KW - groundnuts
KW - liquid chromatography
KW - maize
KW - Mycotoxins
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - corn
KW - fungal toxins
KW - peanut butter
KW - peanuts
KW - Other Produce (QQ070)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206332&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of lead and cadmium in adult canned foods eaten by young children.
AU - Capar, S. G.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 3
SP - 357
EP - 364
AD - Capar, S. G.: U.S. Food and Drug Administration, Division of Contaminants Chemistry, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19921451667. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition
N2 - A US Food and Drug Administration survey of lead and cadmium in 10 adult canned foods commonly eaten by children less than 5 years old was conducted between October 1981 and September 1985. This survey, which included foods preserved by a commercial canning process and packaged in metal containers, found highest mean levels of lead (0.32 µg/g) in tuna and of cadmium (0.02 µg/g) in tuna and tomatoes. Lead levels in foods packaged in lead-soldered cans were about 5 times as high as those in foods packaged in nonlead-soldered cans. Mean lead levels appeared to decline over the 4 years of the study. Cadmium levels were usually below the reporting limit (0.01 µg/g).
KW - Cadmium
KW - CANNED PRODUCTS
KW - Lead
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921451667&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of two immunochemical methods with thin-layer chromatographic methods for determination of aflatoxins.
AU - Trucksess, M. W.
AU - Young, K.
AU - Donahue, K. F.
AU - Morris, D. K.
AU - Lewis, E.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 3
SP - 425
EP - 428
AD - Trucksess, M. W.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19901206652. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology; Postharvest Research; Maize
N2 - Three different methods were compared for the determination of total aflatoxins in maize and groundnuts naturally contaminated with aflatoxins and in maize, groundnuts, cottonseed, groundnut butter and poultry feed spiked with aflatoxins B1, B2 and G1. The 3 methods were an ELISA screening test, a monoclonal antibody-affinity column-solid-phase separation method, and the AOAC official TLC method for all except poultry feed, for which Shannon's TLC method for mixed feed was used. The ELISA test provided only positive results for total aflatoxins at ≥20 ng/g or negative results at <20 ng/g. The affinity column separation was coupled with either bromination solution fluorometry to estimate total aflatoxins or liquid chromatography (LC) to quantitate individual aflatoxins. Fluorodensitometry was used to determine aflatoxins in commodities analysed by the TLC methods. The LC and TLC results were in good agreement for all the analyses. The results for the affinity column using bromination solution fluorometry were similar except those for cottonseed, which were about 60% higher. The ELISA screening method correctly identified naturally contaminated maize and groundnut positive samples. No false positives were found for controls. The correct response for spiked maize, raw groundnuts, groundnut butter, and cottonseed at ≥20 ng aflatoxins/g was approx. 90%. The correct response for spiked poultry feed at ≥20 ng aflatoxins/g was approx. 50%.
KW - affinity chromatography
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - cottonseed
KW - detection
KW - determination
KW - ELISA
KW - estimation
KW - feeds
KW - groundnut butter
KW - groundnuts
KW - maize
KW - Mycotoxins
KW - thin layer chromatography
KW - USA
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - corn
KW - enzyme linked immunosorbent assay
KW - feeding stuffs
KW - fungal toxins
KW - peanut butter
KW - peanuts
KW - United States of America
KW - Other Produce (QQ070)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901206652&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of a tri-enzyme extraction of total folate determination in foods.
AU - Martin, J. I.
AU - Landen, W. O., Jr.
AU - Soliman, A. G. M.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1990///
VL - 73
IS - 5
SP - 805
EP - 808
SN - 1060-3271
AD - Martin, J. I.: Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St., Atlanta, GA 30309, USA.
N1 - Accession Number: 19940400755. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition; Dairy Science
N2 - A tri-enzyme digestion procedure using chicken pancreas conjugase, α-amylase and Pronase® was evaluated to determine its usefulness in the microbiological quantification of total folate in foods. Folate values obtained by traditional conjugase digestion were compared with those obtained by the tri-enzymes method for 12 food products that represent diverse matrices. The tri-enzyme treatment increased measurable folate from most foods when compared with levels found after conjugase digestion. Largest increased were noted for tuna fish (51%) and yoghurt (33%) after tri-enzyme digestion. For the 12 foods, a mean increased of 19% in measureable folate was obtained with tri-enzyme treatment. The study shows that traditional conjugase treatment does not completely free folate for complex food matrices before microbiological analysis. Further, as other investigations have suggested, current accepted methods for folate analysis may be underestimating folate levels in foods. Foods tested included dried skim milk, low fat yoghurt, Brie cheese and milk-based formulae.
KW - Brie cheese
KW - cows
KW - determination
KW - dried milk
KW - dried skim milk
KW - folic acid
KW - foods
KW - infant formulae
KW - milk products
KW - skim milk
KW - yoghurt
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dairy products
KW - folacin
KW - folate
KW - infant formula
KW - infant formulas
KW - joghurt
KW - milk powder
KW - nonfat dry milk
KW - yogurt
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of multiple sulfonamide residues in bovine milk.
AU - Smedley, M. D.
AU - Weber, J. D.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1990///
VL - 73
IS - 6
SP - 875
EP - 879
AD - Smedley, M. D.: Food and Drug Administration, Center for Veterinary Medicine, Division of Veterinary Medical Research, Bldg 328A, BARC-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19912254373. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 57-68-1. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Veterinary Science; Dairy Science
N2 - A liquid chromatographic method for simultaneous determination of residues of 10 sulfonamide drugs at 10 parts/109 and above in raw milk, is based on a chloroform-acetone extraction, evaporation of organic phase, dissolution of residues in an aqueous potassium phosphate solution, and extraction of fatty residue into hexane. The aqueous layer is collected, filtered, injected on to an LC system, and detected by ultraviolet absorption at 265 nm. To elute all 10 sulfonamides isocratically, 2 chromatographic conditions are required. Seven sulfonamides can be measured with 12% methanol in the mobile phase; 4 sulfonamides can be measured with 30% methanol. Sulfadimidine, the most widely used sulfonamide, is detected on both systems. Recoveries are 44-87% for individual sulfonamides, with only 2 below 60%. Coefficients of variation are 3-13% at 10 ng/g level.
KW - assays
KW - Cows
KW - determination
KW - drug residues
KW - Drugs
KW - Liquid chromatography
KW - milk
KW - Milk hygiene
KW - Sulfadimidine
KW - Sulfonamides
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - medicines
KW - pharmaceuticals
KW - sulfamethazine
KW - sulphadimidine
KW - sulphonamides
KW - Pesticides and Drugs (General) (HH400)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Economic implications of a safe food supply.
AU - Gill, R. W.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 1990///
VL - 73
IS - 6
SP - 1662
EP - 1664
SN - 0022-0302
AD - Gill, R. W.: Center for Food Safety and Applied Nutrition, Department of Health and Human Services, Public Health Service, Washington, DC 20204, USA.
N1 - Accession Number: 19900441000. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition; Dairy Science; World Agriculture, Economics & Rural Sociology
N2 - Economic implications of a safe food supply are discussed, with reference to food safety surveillance programmes and product approval in testing in the USA.
KW - costs
KW - Cows
KW - economics
KW - food hygiene
KW - Food safety
KW - Foods
KW - monitoring
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - surveillance systems
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Economics (General) (EE100) (Discontinued June 2002)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Food Industry (EE520) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Iodine concentrations in US milk: variation due to time, season, and region.
AU - Pennington, J. A. T.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 1990///
VL - 73
IS - 12
SP - 3421
EP - 3427
SN - 0022-0302
AD - Pennington, J. A. T.: Division of Nutrition, Food and Drug Administration, Washingtion, DC 20204, USA.
N1 - Accession Number: 19910445326. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 7553-56-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - The iodine content of milk is influenced primarily by the iodine added to animal feed and by iodophor-sanitizing solutions used in the dairy industry. Variability of these practices may result in variation of iodine concn. in milk. Some seasonal and regional variation in iodine concn. in milk may reflect the amount of indoor feeding (i.e. iodine-supplemented feed) during the colder months vs. outdoor pasture feeding during the warmer months. The proportion of indoor vs. outdoor feeding depends on the climate of the particular geographical area. Milks and other milk products from the FDA Total Diet Study were analysed for iodine quarterly from 1982 to 1990. The iodine concn. in liquid milks were evaluated over time, by season (summer, spring, winter and autumn), and by region (E., S., Central and W.). Iodine in liquid milks averaged 23 µg/100 g, and ranged from 16 µg/100 g in the summer and autumn in the E. to 34 µg/100 g in the winter in the E. Iodine was highest in the winter (27 µg/100 g) and lowest in the summer (19 µg/100 g), and higher in W. and central states (25 and 27 µg/100 g resp.) than in E. states (18 µg/100 g).
KW - Cows
KW - Iodine
KW - milk
KW - seasonal variation
KW - Seasons
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dracunculus insignis in ferrets: comparison of inoculation routes.
AU - Brandt, F. H.
AU - Eberhard, M. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1990///
VL - 76
IS - 1
SP - 93
EP - 95
SN - 0022-3395
AD - Brandt, F. H.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900863877. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Helminthology
N2 - Three routes of inoculation were compared to determine the best method to infect Mustela putorius furo with D. insignis. The traditional method of administering infected cyclops containing L3s through gavage was compared to ip and sc inoculation of L3s. Ten of 18 (56%) gavaged ferrets became infected after receiving copepods containing approximately 100 L3s each; 44 adult worms were recovered from these 10 animals. Twenty-one of 28 (75%) animals inoculated with 50 L3s each became infected ip; 92 adult worms were recovered from the positive animals. Four of 5 (80%) ferrets given sc inoculations of 50 L3s became infected; only 6 worms were recovered from these 4 animals. Inoculation of larvae via the ip or sc route greatly simplified the infection procedure and produced more consistent results. A simple procedure is described, which permits rapid recovery of L3s to be used in the ip or sc inoculations.
KW - Disease models
KW - helminths
KW - Human diseases
KW - infection
KW - Laboratory animals
KW - parasites
KW - techniques
KW - Carnivores
KW - Dracunculus insignis
KW - FERRETS
KW - Nematoda
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Dracunculus
KW - Dracunculidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Distribution, behavior, and course of patency of Dracunculus insignis in experimentally infected ferrets.
AU - Brandt, F. H.
AU - Eberhard, M. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1990///
VL - 76
IS - 4
SP - 515
EP - 518
SN - 0022-3395
AD - Brandt, F. H.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900867909. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Veterinary Science; Helminthology
N2 - From 106 ferrets (Mustela putorius furo) experimentally infected with Dracunculus insignis, 273 female worms and 42 male worms were recovered. The percentage of female worms that mated, the location of all worms, and the rate of emergence of gravid females were recorded. Of 174 mature female worms recovered, only 11% had emerged before necropsy. 81% of the male worms and 87% of all unmated (immature) females were found on the trunk of the animal or on the skin overlying it. Gravid female worms were found on the extremities (legs) 88% of the time. Almost a third of gravid female worms were found on the left front leg. On 4 occasions, females were found in unusual locations: the tail, the cheek, the lumbar region of the spinal cord, and the peritoneal cavity associated with the omentum. The results showed that only a small percentage of mature female worms emerge, which suggests that infected persons harbour many more gravid female worms than indicated by reports of emergent worms. More than a third of female worms were not mated, but it is likely that these immature females would be capable of further development. Male worms survived for up to 330 days, suggesting that male or unmated female worms may carry over from one transmission season to the next.
KW - disease models
KW - helminths
KW - Histology
KW - parasites
KW - Pathology
KW - Wild animals
KW - Carnivores
KW - Dracunculidae
KW - Dracunculus insignis
KW - ferrets
KW - Nematoda
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Dracunculus
KW - Dracunculidae
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A technique for microfilarial detection in preserved blood using nuclepore filters.
AU - Dickerson, J. W.
AU - Eberhard, M. L.
AU - Lammie, P. J.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1990///
VL - 76
IS - 6
SP - 829
EP - 833
SN - 0022-3395
AD - Dickerson, J. W.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910870870. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Helminthology; Tropical Diseases
N2 - Nuclepore filtration is now the most widely used method of detecting microfilaraemia, particularly if microfilariae are few in number. However, this system requires the blood sample to be processed promptly after collection. Using blood from Wuchereria bancrofti-infected patients, 3 solutions were tested to determine whether blood could be held for delayed processing. Of these, one was identified, 2% formalin/10% Teepol, in which microfilaraemic blood can be held for at least 9 months without deterioration of microfilarial structure or decrease in microfilarial numbers. In addition, this mixture passed easily through a 5 µm filter at all times tested. Examination of more than 300 blood samples held in 2% formalin/10% Teepol showed that this solution can utilize the convenience and sensitivity of membrane filtration while eliminating the need to perform testing immediately after the blood is collected.<new para>ADDITIONAL ABSTRACT:<new para>Using blood from Wuchereria bancrofti-infected patients the authors showed that a 2% formalin/10% Teepol solution provided the best preservation of microfilarial structure and maintenance of numbers over a 9-month period. The solution passed easily through a 5-µm-pore-size membrane and eliminated the need for performing this procedure immediately after collection of blood.This method is excellent for storing collected material for use at a later time without the precipitation or interference in the morphology of the microfilaria inherent in other concentration solutions.A. Moody
KW - blood
KW - detection
KW - Diagnosis
KW - Filariids
KW - filtration
KW - helminths
KW - Human diseases
KW - microfilariae
KW - parasites
KW - Techniques
KW - Nematoda
KW - Wuchereria bancrofti
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Wuchereria
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - nematodes
KW - nuclepore filters
KW - parasitic worms
KW - preserved blood
KW - Secernentea
KW - Spirurida
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Daily intakes of nine nutritional elements analyzed vs. calculated values.
AU - Pennington, J. A. T.
AU - Wilson, D. B.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1990///
VL - 90
IS - 3
SP - 375
EP - 381
SN - 0002-8223
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19921452130. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
N2 - The daily intakes for 8 age-sex groups (infants, young children, and male and female teenagers, adults, and older adults) of 9 nutritional elements (sodium, potassium, calcium, phosphorus, magnesium, iron, zinc, copper and manganese) were obtained by laboratory analysis of the USA Food and Drug Administration's 234 Total Diet Study (TDS) foods and by use of the USDA Nutrient Data Base for Standard Reference. Food substitutions were required for 8 TDS foods that had no direct counterparts in the USDA database. When corrections were made for missing values for Mg, Zn, Cu and Mn in the USDA database, average percentage differences between the 2 methods (USDA-TDS) for the age-sex groups were -2.6 for Fe, 0.6 for Mn, 0.9 for Zn, 5 for K and P, 7 for Mg, 8 for Na and Ca and 11.0 for Cu. Data in the USDA database (when corrected for missing values) provided estimates of daily intakes of 9 nutritional elements that were similar to those obtained by use of data from laboratory analysis in the TDS.
KW - Diet studies
KW - estimation
KW - food composition tables
KW - intake
KW - Nutrients
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921452130&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Agreement between analytical values and label declarations of sodium content of processed packaged foods.
AU - Cook, K. K.
AU - Gregory, N. R.
AU - Weaver, C. M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1990///
VL - 90
IS - 8
SP - 1085
EP - 1088
SN - 0002-8223
AD - Cook, K. K.: Nutrient Surveillance Branch, Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19901451770. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 7440-23-5. Subject Subsets: Human Nutrition
N2 - As part of the Food Labeling and Product Surveillance Program of the Food and Drug Administration of the USA, samples from 1982, 1984 and 1986 surveys of processed packaged foods (canned, frozen and dry packaged) were analysed to determine how closely the foods' actual sodium content matched their label claims for Na. Samples were classified as: "Na-free" products (less than 5 mg Na per serving), "very-low-Na" products (5 to 35 mg per serving) and a larger group of products that were labelled as containing more than 35 mg Na per serving. In the third group, the distribution of actual Na content fell around 100% of label claims for Na. For the 3 survey years, Na was on average 101% of label claim [standard deviation (s.d.) 25%] for 1982 samples (20 products), 99% of label claim (s.d. 28%) for 1984 samples (108 products) and 94% of label claim (s.d. 21%) for 1986 samples (265 products). Products labelled "very-low-Na" were treated separately because Na analyses varied widely from the label declarations. Most "very-low-Na" products were well under 35 mg Na per serving. Results indicated that consumers receive reasonably accurate information about the Na content of processed packaged foods from label claims.
KW - Foods
KW - sodium
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901451770&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A review of iodine toxicity reports.
AU - Pennington, J. A. T.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1990///
VL - 90
IS - 11
SP - 1571
EP - 1581
SN - 0002-8223
AD - Pennington, J. A. T.: Divison of Nutrition, Center for Food and Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911431123. Publication Type: Journal Article. Language: English. Number of References: 157 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition
N2 - Case reports, population studies and experimental studies from the literature concerning adverse effects of exposure to iodine from the mid-1880s to 1988 are reviewed. Exposure to excessive I through foods, dietary supplements, topical medications and/or iodinated contrast media has resulted in the thyroiditis, goitre, hypothyroidism, hyperthyroidism, sensitivity reactions or acute responses for some persons. Reports of maternal I exposure during pregnancy or lactation affecting newborn or nursing infants are cited. Susceptibility to excess I is discussed as well as the relation between dose and response. It is concluded that some persons can tolerate very high values of I with no apparent side effects and that I intakes ≤ 1.000 mg daily are probably safe for most of the population, but may cause adverse effects in some persons. Estimation of maximum tolerable values of I intake will require human experimental studies at values between 0.150 and 1.000 mg daily for normal subjects, subjects with autonomous thyroid tissue and I-sensitive subjects.
KW - Iodine
KW - reviews
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431123&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microplate assay of glutathione S-transferase activity for resistance detection in single-mosquito triturates.
AU - Brogdon, W. G.
AU - Barber, A. M.
JO - Comparative Biochemistry and Physiology. B, Comparative Biochemistry
JF - Comparative Biochemistry and Physiology. B, Comparative Biochemistry
Y1 - 1990///
VL - 96
IS - 2
SP - 339
EP - 342
AD - Brogdon, W. G.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910503192. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 50-29-3, 50812-37-8. Subject Subsets: Medical & Veterinary Entomology
N2 - Optimum conditions are described for a simple, rapid microplate assay that measured glutathione S-transferase (GST) activity accurately and precisely in small portions of single mosquito homogenates. Up to 10 assay replicates were possible for individual adults and larvae. Concentration of GST activity in the head/thorax region allows blood-fed mosquitoes with abdomens removed to be used in assays. The method allows the use of GST activity as a biochemical character in comparative studies of populations. The microplate assay detected elevated GST activities associated with DDT resistance in Anopheles arabiensis.
KW - assays
KW - Biochemical techniques
KW - DDT
KW - Enzymes
KW - glutathione transferase
KW - insecticide resistance
KW - Organochlorine insecticides
KW - resistance
KW - Spectrophotometry
KW - Anopheles arabiensis
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - dicophane
KW - ligandin
KW - mosquitoes
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticide and Drug Resistance (HH410)
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910503192&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Fatal quinine-induced thrombocytopenia.
AU - Freiman, J. P.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1990///
VL - 112
IS - 4
SP - 308
EP - 309
SN - 0003-4819
AD - Freiman, J. P.: Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19900863184. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Registry Number: 549-56-4, 60-93-5, 6119-70-6, 130-89-2, 130-95-0. Subject Subsets: Protozoology
N2 - Two cases of fatal quinine-induced thrombocytopaenia are reported from the USA. Both patients (a 41 year old woman and a 39 year old man) died of internal haemorrhages secondary to profound thrombocytopaenia which developed almost immediately after ingestion of quinine sulphate for the relief of leg cramps. Both had histories of previous exposure to quinine. An assay for quinine-dependent antiplatelet antibodies was positive in one patient.
KW - Antimalarials
KW - Antiprotozoal agents
KW - Human diseases
KW - parasites
KW - quinine
KW - Toxicity
KW - North America
KW - USA
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - thrombocytopaenia
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900863184&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alteration of gastrointestinal mucin by fiber feeding in rats.
AU - Satchithanandam, S.
AU - Vargofcak-Apker, M.
AU - Calvert, R. J.
AU - Leeds, A. R.
AU - Cassidy, M. M.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1990///
VL - 120
IS - 10
SP - 1179
EP - 1184
SN - 0022-3166
AD - Satchithanandam, S.: Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19911430727. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - To allow a quantitative study of gastrointestinal mucin, a polyclonal antibody to the mucin of the rat small intestine was produced by injecting rabbits with a high-molecular weight subfraction of purified mucin glycoprotein derived from rat intestinal mucin. An enzyme-linked immunosorbent assay was developed and used for the mucin assay. Three groups of male Wistar rats ate freely a diet containing 5% guar gum or 5% citrus fibre or a fibre-free diet for 4 weeks. After feed deprivation overnight, luminal and tissue mucin antibody reactivities were estimated in the rat stomach, colon and small intestine. In all groups, total (luminal and tissue) mucin reactivity was greater in the small intestine than in the colon or stomach. The group given 5% citrus fibre had significantly greater mucin reactivity in luminal samples from stomach and intestine than did the fibre-free control group. Fibre-induced increments in gastrointestinal mucin production or availability may be responsible for several reported consequences of fibre feeding, such as more rapid transit times and delayed or impaired nutrient absorption.
KW - fibre
KW - intestines
KW - Mucins
KW - sources
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fiber
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430727&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of graded dietary levels of Spirulina maxima on vitamins A and E in male rats.
AU - Mitchell, G. V.
AU - Grundel, E.
AU - Jenkins, M.
AU - Blakely, S. R.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1990///
VL - 120
IS - 10
SP - 1235
EP - 1240
SN - 0022-3166
AD - Mitchell, G. V.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911430735. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Male Sprague Dawley rats were given for 6 weeks diets containing 0, 2.7, 10.7, 18.7 and 26.7% Spirulina maxima. All the diets contained 18% protein, which was provided by S. maxima or casein or both of them. Growth of rats given S. maxima was poorer than that of rats given the casein control diet when diets contained more than 10.7% S. maxima. S. maxima significantly increased DM and chloroform-extractable crude fat in the faeces. 2.7% S. maxima reduced plasma, liver and heart α-tocopherol concentrations; there was a pronounced decrease with 10.7% S. maxima and a smaller decrease at higher levels. Liver retinol values in rats increased when S. maxima was added to the diet, suggesting conversion of the naturally occurring carotenoids in S. maxima to vitamin A. However, plasma retinol decreased when S. maxima was given at 10.7% or more. The results show that S. maxima can significantly alter the storage and utilization of vitamins A and E.
KW - metabolism
KW - Retinol
KW - Vitamin E
KW - rats
KW - Spirulina
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Cyanobacteria
KW - Bacteria
KW - prokaryotes
KW - Spirulina
KW - axerophthol
KW - bacterium
KW - Spirulina maxima
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911430735&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition monitoring: interface of science and policy.
AU - McGinnis, J. M.
AU - Harrell, J. A.
AU - Meyers, L. D.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1990///
VL - 120
IS - 11 suppl.
SP - 1437
EP - 1439
SN - 0022-3166
AD - McGinnis, J. M.: Office of Disease Prevention and Health Promotion, United States Public Health Service, Department of Health and Human Services, Washington, DC 20201, USA.
N1 - Accession Number: 19911429612. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - Information collected through nutrition monitoring is an essential component in translating scientific evidence into public policy. The uses of nutrition monitoring data for policy and program decisions are reviewed, recent progress to strengthen the National Nutrition Monitoring System is described, and challenges that lie ahead in the nutrition monitoring arena are outlined.
KW - Food policy
KW - Nutrition surveys
KW - reviews
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American Institute of Nutrition
KW - nutritional surveys
KW - United States of America
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429612&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selection of nutrition status indicators for field surveys: the NHANES III design.
AU - Woteki, C. E.
AU - Briefel, R.
AU - Hitchcock, D.
AU - Ezzati, T.
AU - Maurer, K.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1990///
VL - 120
IS - 11 suppl.
SP - 1440
EP - 1445
SN - 0022-3166
AD - Woteki, C. E.: Division of Health Examination Statistics, National Center for Health Statistics, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Hyattsville, MD 20782, USA.
N1 - Accession Number: 19911429613. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - The planning process for a multipurpose survey is described using the third National Health and Nutrition Examination Survey (NHANES III) as an example. The evaluation criteria used were the scientific merit of the topic, its public health importance, its practical utility to the government, and the feasibility of implementing it within the survey's mode of operation. After the topics have been selected, questionnaires and examination protocols are developed, pilot tested, and revised prior to implementing the survey. Procedures are established for providing informed consent and assuring the confidentiality of findings.
KW - Nutrition surveys
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American Institute of Nutrition
KW - nutritional surveys
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911429613&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Synthetic peptides of Venezuelan equine encephalomyelitis virus E2 glycoprotein I. Immunogenic analysis and identification of a protective peptide.
AU - Hunt, A. R.
AU - Johnson, A. J.
AU - Roehrig, J. T.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1990///
VL - 179
IS - 2
SP - 701
EP - 711
SN - 0042-6822
AD - Hunt, A. R.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19922270355. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - Of 14 synthetic peptides representing 67% of the extramembranes domain of Venezuelan equine encephalomyelitis (VEE) virus E2 glycoprotein, examined for antigenic, immunogenic and protective properties, 13 induced antibody to the homologous peptide, 13 induced antiviral antibody that recognized the Trinidad (TRD) strain of VEE virus, the TC-83 vaccine strain, or both and 2, Ve2pep01 (TE-83) and VE2pep01 (TRD), protected mice from challenge with TRD virus. Most of the peptides reacted with immune sera from mice immunized with different subtypes of VEE virus. A competitive binding assay using antipeptide antibodies to block anti-VEE virus monoclonal antibodies supported earlier findings on the spatial relationship of E2 epitopes and gave evidence for a special overlap of the E2 terminus with a domain of residues 180-210.
KW - Arboviruses
KW - epitopes
KW - glycoproteins
KW - Immunization
KW - peptides
KW - Strain differences
KW - Vaccines
KW - viral diseases
KW - Viral proteins
KW - Alphavirus
KW - Equine encephalomyelitis virus
KW - Mice
KW - Togaviridae
KW - Venezuelan equine encephalitis virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Alphavirus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - equine encephalomyelitis virus
KW - antigenic determinants
KW - arthropod-borne viruses
KW - immune sensitization
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - viral infections
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922270355&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diabetogenic response to streptozotocin varies among obese yellow and among lean agouti (BALB/c X VY)F1 hybrid mice.
AU - Wolff, G. L.
AU - Greenman, D. L.
AU - Frigeri, L. G.
AU - Morrissey, R. L.
AU - Suber, R. L.
AU - Felton, R. P.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1990///
VL - 193
IS - 2
SP - 155
EP - 163
SN - 0037-9727
AD - Wolff, G. L.: National Center for Toxicological Research, Food and Drug Administration, US Department of Health and Human Services, Jefferson, AR 72079, USA.
N1 - Accession Number: 19901450404. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
N2 - To test the hypothesis that the increased insulin in obese neoplasia-susceptible yellow Avy/- mice might be a main factor stimulating tumour formation, it is necessary to use normoinsulinaemic yellow mice. Although the attempt to obtain normoinsulinaemic, euglycaemic mice by streptozotocin treatment was unsuccessful, significant differences in the responsiveness to this treatment were observed among mice of identical genotype. These differences were observed among female yellow Avy/A and agouti A/a (BALB/c X VY)F1 hybrid mice in the responses of body weight gain, plasma glucose and plasma insulin values to a single intraperitoneal injection of streptozotocin (STZ) 150 or 200 mg/kg at 4 weeks and followed by a 22-week observation period. Among mice treated with the high streptozotocin dose, 80% of the yellow mice gained almost no weight and became grossly hyperglycaemic and hypoinsulinaemic; only 55% of the agouti mice exhibited such a strong response. In the low dose group, 25% of the yellow mice responded with reduced body weight gain, decreased insulin and increased glucose values whereas none of the agouti mice exhibited such responses. More pancreatic islet tissue mass was present in the untreated yellow control mice than among the comparable agouti mice by the end of the study. In both streptozotocin dose groups and in both genotypes, islet tissue mass was reduced to a much greater extent in the more responsive mice than in the less responsive mice. There seemed to be no correlation between islet tissue mass and insulin value.
KW - genotypes
KW - responses
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptozotocin
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19901450404&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary tin and copper on rat hepatocellular antioxidant protection.
AU - Reicks, M.
AU - Rader, J. I.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1990///
VL - 195
IS - 1
SP - 123
EP - 128
SN - 0037-9727
AD - Reicks, M.: Division of Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911431858. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 7440-50-8, 7440-31-5. Subject Subsets: Human Nutrition
N2 - The effects of dietary tin on copper status and on enzymes and metabolites involved in hepatocellular antioxidant protection were studied in rats given diets adequate or deficient in Cu with glucose or fructose. Rats became Cu-depleted after 4 weeks on diets with Cu <0.5 µg/g as evidenced by significant decreases in liver Cu and serum ceruloplasmin. Signs of Cu deficiency occurred in Cu-depleted rats given diets with Sn 100 µg/g. Significant effects of Sn on liver glutathione peroxidase and superoxide dismutase activities and on liver iron and total glutathione concentrations were observed. Interactions between Cu and Sn on liver Cu and Fe and on liver superoxide dismutase and malondialdehyde production are reported. Adverse effects of diets with Sn 100 µg/g include Cu depletion in rats given Cu-adequate diets, accelerated development of Cu deficiency in rats given Cu-deficient diets and reduction in hepatocellular antioxidant protection.
KW - Copper
KW - deficiency
KW - enzymes
KW - interactions
KW - liver
KW - tin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911431858&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clean-up techniques for pesticides in fatty foods.
AU - Walters, S. M.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 1990///
VL - 236
IS - 1
SP - 77
EP - 82
SN - 0003-2670
AD - Walters, S. M.: Pesticides and Industrial Chemicals Research Center, Food and Drug Administration, 1560 E. Jefferson Ave., Detroit, MI 48207, USA.
N1 - Accession Number: 19911432296. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Agricultural Entomology; Weeds; Weeds; Medical & Veterinary Entomology; Human Nutrition
N2 - The separation of pesticides and other chemical contaminants from high-fat food samples prior to further steps in the analytical process (usually gas chromatography) is a problem to which much effort in method development has been applied. Early methods involved liquid-liquid partitioning, adsorption chromatography and chemical destruction of lipids with strong base and acid. These techniques had limited applicability, especially with the advent of more polar and labile pesticides. Later developments involving sweep codistillation, gel-permeation chromatography and reversed-phase liquid chromatography on alkyl-bonded microparticulate silica are applicable to a wider range of analytes and are generally faster and more efficient and consume less reagents. Supercritical fluid extraction should prove useful in this regard. A brief overview of methods developed for isolating trace levels of environmental contaminants from lipids is presented.
KW - agricultural entomology
KW - analytical methods
KW - Animal fat
KW - estimation
KW - Fat products
KW - foods
KW - Herbicides
KW - Pesticide residues
KW - Pesticides
KW - residues
KW - separation
KW - Techniques
KW - analytical techniques
KW - separating
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911432296&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bovine growth hormone: human food safety evaluation.
AU - Juskevich, J. D.
AU - Guyer, C. G.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1990///
VL - 249
IS - 4971
SP - 875
EP - 884
SN - 0036-8075
AD - Juskevich, J. D.: C. G. Guyer, Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Chemistry, 5600 Fishers Lane, Room 8-81, Rockville, MD 20857, USA.
N1 - Accession Number: 19910187817. Publication Type: Journal Article. Language: English. Number of References: 72 ref. Registry Number: 9002-72-6. Subject Subsets: Agricultural Biotechnology; Dairy Science
N2 - This review explains the approval process of the Food and Drug Administration of the USA, and summarises the scientific information used by the agency to evaluate the human safety of recombinant bovine somatotropin (rbST) when used on dairy cattle. The evaluation concluded that the use of rbST presents no increased health risk to consumers. The hormone is not biologically active in humans, and oral toxicity studies have demonstrated that it is not orally active in rats, a species responsive to parenterally administered rbST. Treatment with rbST produces an increase in the concentration of insulin-like growth factor-I (IGF-I) in cow's milk. However, oral toxicity studies have shown that bovine IGF-I lacks oral activity in rats. Additionally, the concentration of IGF-I in milk of rbST-treated cows is within the normal physiological range found in human breast milk, and IGF-I is denatured under conditions used to process cow's milk for infant feeding. On the basis of estimates of the amount of protein absorbed intact in humans and the concentration of IGF-I in cow's milk during rbST treatment, biologically significant levels of intact IGF-I would not be absorbed.
KW - Biotechnology
KW - Cows
KW - dairy cattle
KW - milk
KW - reviews
KW - safety
KW - Somatotropin
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - growth hormone
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910187817&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A new arbovirus from Aedes albopictus, an Asian mosquito established in the United States.
AU - Francy, D. B.
AU - Karabatsos, N.
AU - Wesson, D. M.
AU - Moore, C. G., Jr.
AU - Lazuick, J. S.
AU - Niebylski, M. L.
AU - Tsai, T. F.
AU - Craig, G. B., Jr.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1990///
VL - 250
IS - 4988
SP - 1738
EP - 1740
SN - 0036-8075
AD - Francy, D. B.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19910504115. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Ten strains of a new arbovirus belonging to the Bunyamwera group (Bunyaviridae) were recovered from pools of (non-blood engorged) A. albopictus collected during a survey conducted in Potosi, Missouri, in August-September 1986 (minimal infection rates, 0.4 per 1000 mosquitoes in August and 8.9 per 1000 in September). Two representative strains (89-3380 and 89-3470) were characterized and shown to be identical to each other and distantly related to Tensaw (TEN) virus. The other 8 strains were either identical or very closely related. Neutralization tests with other members of the Bunyamwera group showed that the new virus was distinct from any of 9 western hemisphere Bunyamwera group viruses, and from the sole Asian member of this serogroup (Batai virus). The name Potosi virus is proposed for the new virus. This evidence indicates that A. albopictus may serve as an arbovirus vector in the USA. The urban-suburban distribution, aggressive behaviour, and broad viral susceptibility of A. albopictus may lead to the transmission of viruses of known public health importance and perhaps of viruses hitherto not transmitted to humans because of the feeding pattern of their usual vectors.
KW - Arboviruses
KW - disease vectors
KW - Introduced species
KW - Mosquito-borne diseases
KW - new species
KW - taxonomy
KW - vectors
KW - Missouri
KW - North America
KW - USA
KW - Aedes albopictus
KW - Bunyamwera virus
KW - Bunyaviridae
KW - Culicidae
KW - Diptera
KW - Orthobunyavirus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - Bunyamwera serogroup viruses
KW - Bunyavirus
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Potosi virus
KW - systematics
KW - United States of America
KW - Taxonomy and Evolution (ZZ380)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910504115&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - More on making sushi safe.
AU - Jackson, G. J.
AU - Bier, J. W.
AU - Schwarz, T. L.
T2 - New England Journal of Medicine
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1990///
VL - 322
IS - 14
SP - 1011
EP - 1011
SN - 0028-4793
AD - Jackson, G. J.: Food and Drug Administration, Washington DC 20204, USA.
N1 - Accession Number: 19900864688. Publication Type: Correspondence. Language: English. Number of References: 22 ref. Subject Subsets: Helminthology
N2 - In response to several letters on the subject of safe sushi (New England Journal of Medicine (1989) 321, 900-901), the US Food and Drug Administration's recommendations on the storage of fish served raw, marinated, or partially cooked, are summarized. Other types of fish recipes associated with helminthic infections are also mentioned. The reasons why irradiation of fish (for the control of parasites) is not legal, is discussed.
KW - control
KW - fish
KW - Helminths
KW - Human diseases
KW - parasites
KW - storage
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900864688&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Health risks of salmon sushi.
AU - Adams, A. A.
AU - Beeh, J. L.
AU - Wekell, M. M.
T2 - Lancet (British edition)
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1990///
VL - 336
IS - 8726
SP - 1328
EP - 1328
SN - 0140-6736
AD - Adams, A. A.: Seafood Products Research Center, US Food and Drug Administration, PO Box 3012, 22201 23rd Dr. S. E. Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19910869330. Publication Type: Correspondence. Language: English. Number of References: 8 ref. Subject Subsets: Helminthology; Rice; Human Nutrition
N2 - The parasite content of salmon-sushi and the microbiological quality of rice was studied in takeout meals ordered from 14 of the 50 restaurants that serve sushi in Seattle, Washington, USA. A sample was also purchased from a specialist grocery store that supplies many restaurants with seafood. In 92 individual pieces of salmon-sushi, a one in 13 chance of encountering an anisakid larva was found, with the possibility of ingesting up to 3 larvae from a single slice. Larvae were not visible by eye before artificial digestion by pepsin. All the larvae recovered during this study were dead. The salmon were proved to have been frozen after the cold-smoking process, lending support to the US Food and Drug Administration's recommendation that fish served raw or undercooked be properly frozen before consumption. The pH of the rice from the 14 restaurants ranged from 4.0 to 4.6, well within public health guidelines. Aerobic plate counts were done on 59 samples of rice, with counts ranging from 10³-107/g rice. 55 samples from 13 restaurants were tested for Staphylococcus aureus and Bacillus cereus; 3 restaurants had positive samples for S. aureus with 4-9 organisms/g rice; samples from 3 restaurants also tested positive for B. cereus with 4-93 organisms/g rice. These levels are not, however, usually considered to be of public health importance.
KW - fish
KW - Food
KW - Food products
KW - helminths
KW - Human diseases
KW - parasites
KW - Seafoods
KW - sushi
KW - North America
KW - USA
KW - Washington
KW - Anisakis
KW - bacteria
KW - Nematoda
KW - Anisakidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - Ascaridida
KW - bacterium
KW - nematodes
KW - parasitic worms
KW - prevalence
KW - Secernentea
KW - Takeout foods
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910869330&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Foodborne illness. US food legislation.
AU - Thompson, P.
AU - Salsbury, P. A.
AU - Adams, C.
AU - Archer, D. L.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1990///
VL - 336
IS - 8730
SP - 1557
EP - 1559
SN - 0140-6736
AD - Thompson, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19921444167. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - Legislation concerning food safety in the USA is briefly reviewed.
KW - Food legislation
KW - foodborne diseases
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921444167&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Organic nutrient content of the US Food and Drug Administration's Total Diet and its possible use as a Standard Reference Material.
AU - Tanner, J. T.
AU - Iyengar, G. V.
AU - Wolf, W. R.
JO - Fresenius' Journal of Analytical Chemistry
JF - Fresenius' Journal of Analytical Chemistry
Y1 - 1990///
VL - 338
IS - 4
SP - 438
EP - 440
SN - 0937-0633
AD - Tanner, J. T.: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition (HFF-266), Washington, DC 20204, USA.
N1 - Accession Number: 19921448421. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - Mixed diet composites containing 201 different foods from the United States Food and Drug Administration's Total Diet Study have been prepared to represent the intake of a 25- to 30-year-old male in the US. To date, foods from 10 different collections have been received and composites representing 6 collections have been prepared and assayed. Each composite, representing 1 of 4 different geographical areas of the USA (West, South, Northeast, North Central), was assayed for proximates (fat, protein, moisture, carbohydrates and ash), elemental composition and organic nutrient content. The elemental content is reported separately. Proximate and organic nutrient content are discussed. The organic nutrients determined were thiamin, riboflavin, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid and biotin. The results show no significant variations in the contents among the individual collections. Portions of the collections have been freeze-dried and mixed to prepare a total diet reference material. Analytical results for nutrient content of the dry material are equivalent to those of the original composite.
KW - Food composition
KW - standards
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448421&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Matrix effects in biological reference materials used in the standardization of cholesterol measurements.
AU - Myers, G. L.
AU - Waymack, P. P.
JO - Fresenius' Journal of Analytical Chemistry
JF - Fresenius' Journal of Analytical Chemistry
Y1 - 1990///
VL - 338
IS - 4
SP - 538
EP - 542
SN - 0937-0633
AD - Myers, G. L.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19921448431. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - The problem of matrix effects in cholesterol materials are reviewed and the results of several studies evaluating sources of matrix error are presented. An alternate approach to documenting accuracy, to be used until commutable materials free of matrix effects are available, is also discussed.
KW - blood
KW - Cholesterol
KW - errors
KW - estimation
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448431&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological reference materials for assaying human albumin in urine.
AU - Mueller, P. W.
AU - MacNeil, M. L.
AU - Steinberg, K. K.
JO - Fresenius' Journal of Analytical Chemistry
JF - Fresenius' Journal of Analytical Chemistry
Y1 - 1990///
VL - 338
IS - 4
SP - 543
EP - 546
SN - 0937-0633
AD - Mueller, P. W.: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19921448432. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - To assess the interlaboratory variation in the results of albumin estimations, albumin solutions in human urine at various concentrations within the normal range were prepared. As some investigators have reported that albumin is unstable in some human urine samples stored at -20°C, urine samples from 21 persons were screened to identify samples that were stable under these conditions and that had low native albumin content. The urine of 2 donors met these criteria, and they provided urine, which was prefiltered, sterile-filtered, and spiked with commercially available human serum albumin. The albumin was characterized as pure by a Lowry assay of protein content with National Institute of Standards and Technology bovine serum albumin (standard reference material 926) as the standard and by the appearance of one band on agarose gel electrophoresis. To evaluate the necessity for additional stabilization when urine samples are stored at -20°C, a surfactant was included in one set of materials and not included in another. The materials with surfactant were evaluated for 10.5 months and those without surfactant for 5 months. The preserved materials showed no significant loss of activity during this period. The unpreserved materials remained stable for 2 months, and then the 2 higher level materials appeared to lose activity. The negative slope of the highest value of unpreserved material was significant (P = 0.01) during this period. In our laboratory, the albumin recovered by enzyme immunoassay was 106.7% and 115.9% in 2 preserved normal-range materials and 102.2% and 105.3% in similar unpreserved materials.
KW - Albumins
KW - estimation
KW - urine
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448432&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of boron in food and biological reference materials by neutron capture prompt-γ activation.
AU - Anderson, D. L.
AU - Cunningham, W. C.
AU - Mackey, E. A.
JO - Fresenius' Journal of Analytical Chemistry
JF - Fresenius' Journal of Analytical Chemistry
Y1 - 1990///
VL - 338
IS - 4
SP - 554
EP - 558
SN - 0937-0633
AD - Anderson, D. L.: United States Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19921448433. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 7440-42-8. Subject Subsets: Human Nutrition
N2 - Boron concentrations were estimated by in-beam neutron capture prompt-γ activation analysis for 31 food and biological reference materials prepared by the National Institute of Standards and Technology, Agriculture Canada, the National Institute for Environmental Studies of Japan, and the International Atomic Energy Agency. Sensitivity and background enhancements that are consequences of neutron scattering in hydrogenous matrices such as biological reference materials are discussed, as are correction methods for nuclide interferences, with emphasis on sodium. The limit of quantitation for these materials is 1.0 to 2.5 µg/g and the limit of detection is 0.3 to 0.8 µg/g, depending on the irradiation time. For materials with boron concentrations ≥30 µg/g (e.g., most botanicals), the total analytical uncertainty is ≤2%.
KW - Boron
KW - estimation
KW - foods
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921448433&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of mefloquine in blood by supercritical fluid chromatography with electron-capture detection.
AU - Mount, D. L.
AU - Patchen, L. C.
AU - Churchill, F. C.
JO - Journal of Chromatography, Biomedical Applications
JF - Journal of Chromatography, Biomedical Applications
Y1 - 1990///
VL - 527
IS - 1
SP - 51
EP - 58
SN - 0378-4347
AD - Mount, D. L.: Control Technology Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900865179. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 51773-92-3, 53230-10-7. Subject Subsets: Protozoology
N2 - Supercritical fluid chromatography (SFC) with electron-capture detection for the sensitive quantification of mefloquine in 0.1 ml blood samples is described. The method is internally standardized and incorporates partitioning into methyl tert.-butyl ether (MTBE) from aqueous base, back-extraction into dilute aqueous acid and final partitioning into MTBE from aqueous base. SFC conditions include a silica-gel-packed, glass-lined steel column and a mobile phase of 0.15% n-butylamine and 1% methanol in supercritical n-pentane. The method has a detection limit of 7.5 ng/ml in 0.1 ml blood samples and exhibits good linearity and precision. The method compared favourably with a published HPLC procedure in the analysis of blood from volunteers who received mefloquine hydrochloride (15 mg as base/kg bwt).
KW - Antimalarials
KW - Antiprotozoal agents
KW - blood
KW - Chromatography
KW - Human diseases
KW - mefloquine
KW - parasites
KW - Techniques
KW - protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - quantification
KW - supercritical fluid chromatography
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of blood and urine samples from Macaca mulatta for pyronaridine by high-performance liquid chromatography with electrochemical detection.
AU - Wages, S. A.
AU - Patchen, L. C.
AU - Churchill, F. C.
JO - Journal of Chromatography, Biomedical Applications
JF - Journal of Chromatography, Biomedical Applications
Y1 - 1990///
VL - 527
IS - 1
SP - 115
EP - 126
SN - 0378-4347
AD - Wages, S. A.: Control Technology Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900865180. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 74847-35-1. Subject Subsets: Protozoology
N2 - An HPLC method with electrochemical detection for quantifying pyronaridine in rhesus monkey (Macaca mulatta) blood and urine samples is described. The detection limit is 20 ng/ml at a signal-to-noise ratio of 4 in 0.5 ml samples of blood or urine. Blood analysis includes a liquid-liquid extraction and a subsequent solid-phase extraction that removes an interferent present in blood. For urine, a back-extraction is substituted for the solid-phase extraction step. The method uses an analogue of amodiaquine as internal standard, a 10 µm rigid macroporous styrene-divinylbenzene copolymer column and a mobile phase of 1% (v/v) triethylamine in methanol-water (34:66, v/v).
KW - Antimalarials
KW - Antiprotozoal agents
KW - blood
KW - Chromatography
KW - Human diseases
KW - liquid chromatography
KW - parasites
KW - pyronaridine
KW - Techniques
KW - urine
KW - protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - quantification
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865180&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved high-performance liquid chromatographic method for quantitation of ivermectin in whole blood, serum or muscle tissue.
AU - Dickinson, C. M.
JO - Journal of Chromatography, Biomedical Applications
JF - Journal of Chromatography, Biomedical Applications
Y1 - 1990///
VL - 528
IS - 1
SP - 250
EP - 257
SN - 0378-4347
AD - Dickinson, C. M.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19900865935. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 70288-86-7. Subject Subsets: Helminthology
KW - Anthelmintics
KW - blood
KW - helminths
KW - HPLC
KW - Human diseases
KW - ivermectin
KW - liver
KW - muscles
KW - parasites
KW - serum
KW - Techniques
KW - high performance liquid chromatography
KW - parasitic worms
KW - quantification
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19900865935&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evidence supporting the hypothesis that rickettsial virulence factors determine the severity of spotted fever and typhus group infections.
AU - McDade, J. E.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1990///
VL - 590
SP - 20
EP - 26
SN - 0077-8923
SN - 0897665910\0897665929
AD - McDade, J. E.: Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910501729. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
KW - hosts
KW - infections
KW - Rickettsial diseases
KW - Virulence
KW - Man
KW - Rickettsia akari
KW - Rickettsia australis
KW - Rickettsia conorii
KW - Rickettsia montanensis
KW - Rickettsia prowazekii
KW - Rickettsia rickettsii
KW - Rickettsia sibirica
KW - Rickettsia typhi
KW - Rickettsiaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Rickettsia montana
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910501729&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of DNA probes for differentiation of spotted fever group and other rickettsiae.
AU - Regnery, R.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1990///
VL - 590
SP - 422
EP - 429
SN - 0077-8923
SN - 0897665910\0897665929
AD - Regnery, R.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910501752. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2 - Some aspects of differentiation of rickettsiae by DNA analysis are reviewed, and a preliminary report is given of new technologies that may be applied to the genotypic study of the rickettsiae. Methods discussed are direct restriction endonuclease fragment length polymorphism (RFLP) analysis, labelled probe/Southern blot RFLP analysis, and polymerase chain reaction/RFLP analysis.
KW - Biotechnology
KW - diagnosis
KW - DNA
KW - DNA probes
KW - identification
KW - Immunoblotting
KW - Molecular genetics
KW - Polymerase chain reaction
KW - Restriction fragment length polymorphism
KW - species
KW - Coxiella burnetii
KW - Rickettsia
KW - Rickettsiaceae
KW - Coxiella
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - bacterium
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - PCR
KW - RFLP
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Techniques and Methodology (ZZ900)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910501752&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Rickettsia rickettsii DNA in clinical specimens by enzymatic amplification using polymerase chain reaction technology.
AU - Tzianabos, T.
AU - Anderson, B. E.
AU - McDade, J. E.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1990///
VL - 590
SP - 553
EP - 556
SN - 0077-8923
SN - 0897665910\0897665929
AD - Tzianabos, T.: Viral and Rickettsial Zoonoses Branch, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, United States Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910501756. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Entomology
KW - diagnosis
KW - DNA amplification
KW - Human diseases
KW - Polymerase chain reaction
KW - Rickettsial diseases
KW - man
KW - Rickettsia rickettsii
KW - Rickettsiaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910501756&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neutron capture prompt-γ activation analysis of foods.
AU - Anderson, D. L.
AU - Cunningham, W. C.
AU - Mackey, E. A.
JO - Biological Trace Element Research
JF - Biological Trace Element Research
Y1 - 1990///
VL - 26 & 27
SP - 613
EP - 622
SN - 0163-4984
AD - Anderson, D. L.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC, USA.
N1 - Accession Number: 19911432175. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - Neutron capture prompt-γ activation analysis (PGAA) for multielement analysis of food was investigated. A total of 22 elements were observed in 40 food and mineral supplements hydrogen, boron, carbon, nitrogen, sodium, sulphur, chlorine and potassium concentrations were estimated in National Institute of Standards and Technology RM 8431a Mixed Diet and in a wet diet composite made from Food and Drug Administration Total Diet Study collections. Because the neutron flux was low for PGAA, the method was non-destructive and reanalysis of analytical portions was possible. Both diet materials were analysed before and after freeze-drying to check for element losses during this process. No losses were found for RM 8431a, but losses of B and Na were significant for the wet composite. The measured loss of hydrogen for the wet composite was not consistent with the assumption that the lost mass was water only.
KW - estimation
KW - foods
KW - Minerals
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911432175&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - An initial investigation into human factors design and evaluation criteria for manually adjustable retrofit ROPS.
AU - Etherton, J. R.
T2 - Paper - American Society of Agricultural Engineers
JO - Paper - American Society of Agricultural Engineers
JF - Paper - American Society of Agricultural Engineers
Y1 - 1990///
IS - 90-1618
SP - 8
EP - 8
SN - 0149-9890
AD - Etherton, J. R.: National Institute for Occupational Safety and Health, Division of Safety Research, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505, USA.
N1 - Accession Number: 19922451822. Publication Type: Miscellaneous. Language: English. Number of References: 17 ref. Subject Subsets: Agricultural Engineering
N2 - A preliminary assessment of ergonomic performance factors, required for use of rollover protective structures (ROPS) on tractors, is presented. Development of retrofit ROPS which can be adjusted down and out of the way if they interfere with how a farmer uses his tractor, when there is no rollover hazard, is proposed.
KW - ergonomics
KW - Roll over protection structures
KW - safety
KW - tractors
KW - antiroll structures
KW - human engineering
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Farm Vehicles as Power Sources (NN200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922451822&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Environmental contaminants in table-ready foods from the Total Diet Program of the Food and Drug Administration.
AU - Heikes, D. L.
A2 - J. O. Nriagu
A2 - M. S. Simmons
T2 - Advances in Environmental Science and Technology.
JO - Advances in Environmental Science and Technology.
JF - Advances in Environmental Science and Technology.
Y1 - 1990///
SP - 31
EP - 57
CY - New York: J. Wiley & Sons, Inc.; USA
SN - 0471508918
AD - Heikes, D. L.: Total Diet Research Center, Food and Drug Administration, Kansas City, Missouri, USA.
N1 - Accession Number: 19931456304. Publication Type: Miscellaneous. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - The United States Food and Drug Administration (FDA) surveys residue levels of environmental contaminants in the diet. The following are discussed: the history of the Total Diet Program study; the current Total Diet Program; analytical procedures for isolation of contaminants; analytical results of table-ready foods studied; and emerging and novel contaminants.
KW - Analytical methods
KW - Chemicals
KW - Consumers
KW - Environment
KW - Food contamination
KW - Nutrition programmes
KW - Pesticide residues
KW - Processing
KW - Residues
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - feeding programmes
KW - feeding programs
KW - food contaminants
KW - food programs
KW - nutrition programs
KW - United States of America
KW - Animal Nutrition (Production Responses) (LL520)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456304&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Plague in the U.S.: present and future.
AU - Barnes, A. M.
A2 - Davis, L.R.
A2 - Marsh, R.E.
T2 - Proceedings Fourteenth Vertebrate Pest Conference, 6-8 March 1990, Sacramento, California.
JO - Proceedings Fourteenth Vertebrate Pest Conference, 6-8 March 1990, Sacramento, California.
JF - Proceedings Fourteenth Vertebrate Pest Conference, 6-8 March 1990, Sacramento, California.
Y1 - 1990///
SP - 43
EP - 46
CY - Davis, California; USA
PB - University of California, Davis
AD - Barnes, A. M.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950507845. Publication Type: Conference paper. Language: English. Number of References: 5 ref. Registry Number: 63-25-2, 52645-53-1.
N2 - An increasing trend in the frequency of human bubonic plague (Yersinia pestis) cases in the USA, the principal sources of human infection and emerging control techniques are described. Development of an integrated control programme involving public health education, citizen participation in plague surveillance and insecticidal control of flea vectors in response to evidence of plague and potential human exposure substantially reduced human plague cases in a Bernalillo County, New Mexico, hyperendemic plague area. Permethrin 0.5% dust (Pyraperm 455) applied at 7 g per burrow provided effective control of flea vectors for at least 6 weeks.
KW - carbamate insecticides
KW - carbaryl
KW - chemical control
KW - control programmes
KW - disease vectors
KW - dusts
KW - epidemiology
KW - human diseases
KW - permethrin
KW - plague
KW - pyrethroids
KW - reservoir hosts
KW - wild animals
KW - zoonoses
KW - New Mexico
KW - USA
KW - Ammospermophilus
KW - Ammospermophilus leucurus
KW - Diamanus
KW - Diamanus montanus
KW - man
KW - Oropsylla
KW - Sciuridae
KW - Spermophilus beecheyi
KW - Spermophilus variegatus
KW - Yersinia pestis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Ceratophyllidae
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - rodents
KW - Spermophilus
KW - Sciuridae
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ammospermophilus
KW - Diamanus
KW - Oropsylla
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - animal reservoirs
KW - bacterium
KW - control programs
KW - Oropsylla bacchi
KW - Oropsylla montana
KW - Sciurinae
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507845&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Prevention of Coxiella burnetii infection: vaccines and guidelines for those at risk.
AU - Ormsbee, R. A.
AU - Marmion, B. P.
A2 - Marrie, T.J.
T2 - Q fever. Volume I. The disease.
JO - Q fever. Volume I. The disease.
JF - Q fever. Volume I. The disease.
Y1 - 1990///
SP - 225
EP - 248
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849359848
AD - Ormsbee, R. A.: US Public Health Service, Hamilton, MN, USA.
N1 - Accession Number: 19920508261. Publication Type: Miscellaneous. Language: English. Number of References: 125 ref. Subject Subsets: Medical & Veterinary Entomology
KW - Antigens
KW - Human diseases
KW - Q fever
KW - reviews
KW - Rickettsial diseases
KW - vaccines
KW - Coxiella burnetii
KW - Coxiella
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - abattoir fever
KW - antigenicity
KW - bacterium
KW - Balkan grippe
KW - Derrick-Burnet disease
KW - immunogens
KW - Nine Mile fever
KW - pneumorickettsiosis
KW - quadrilateral fever
KW - query fever
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920508261&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The use of rollover protection on farm tractors in West Virginia.
AU - Etherton, J.
AU - Myers, J.
A2 - Das, B.
T2 - Advances in industrial ergonomics and safety. II. Proceedings of the annual international industrial ergonomics and safety conference, Montreal, Quebec, Canada, 10-13 June 1990..
JO - Advances in industrial ergonomics and safety. II. Proceedings of the annual international industrial ergonomics and safety conference, Montreal, Quebec, Canada, 10-13 June 1990..
JF - Advances in industrial ergonomics and safety. II. Proceedings of the annual international industrial ergonomics and safety conference, Montreal, Quebec, Canada, 10-13 June 1990..
Y1 - 1990///
SP - 819
EP - 825
CY - London; UK
PB - Taylor and Francis
SN - 0860667488
AD - Etherton, J.: National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia, USA.
N1 - Accession Number: 19912449864. Publication Type: Conference paper. Language: English. Number of References: 19 ref. Subject Subsets: Agricultural Engineering
N2 - Farm tractor rollovers kill about 200 workers each year in the USA. The most effective way to prevent such fatalities, after the rollover occurs, is the use of Rollover Protective Structures (ROPS). A survey of farm safety in West Virginia indicates that about half of the tractors purchased since 1985, the year voluntary standards were implemented which recommended ROPS for all newly manufactured tractors, do not have a ROPS and that overall only about 20% of West Virginia tractors have it. This failure to use ROPS is an important fatality risk factor in a state where the farm land includes significant rolling and steep terrain. Suggestions are made on human factors research to increase the number of ROPS retrofits in West Virginia as well as in the rest of the U.S.
KW - Roll over protection structures
KW - safety
KW - tractors
KW - USA
KW - West Virginia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - Annual international industrial ergonomics and safety conference
KW - antiroll structures
KW - United States of America
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Farm Vehicles as Power Sources (NN200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912449864&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Gene probes for Listeria monocytogenes.
AU - Datta, A. R.
A2 - Miller, A. J.
A2 - Smith, J. L.
A2 - Somkuti, G. A.
T2 - Foodborne listeriosis: topics in industrial microbiology Volume 2.
Y1 - 1990///
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers, Journals Division
SN - 0444811869
AD - Datta, A. R.: Divison of Microbiology, CFSAN Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19920449757. Publication Type: Book chapter. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - This chapter reviews the state of development of gene probes for Listeria monocytogenes identification and enumeration in foods. The development of gene-probe hybridization techniques is desirable because they are much more rapid than cultural methods and biochemical tests. Work has been carried out on probes for the detection of virulence factor genes in an attempt to detect pathogenic strains specifically. Of the 7 Listeria spp. only L. monocytogenes is generally regarded as being pathogenic. Listeria monocytogenes has at least 2 haemolysin genes (α-listeriolysin and β-listeriolysin). A 500-basepair HindIII-HinCI fragment of the β-listeriolysin gene has been used to screen many Listeria strains and has exhibited specificity for Listeria monocytogenes. This fragment has been sequenced and several 20-nucleotide-long synthetic oligonucleotide probes have been developed. The α-listeriolysin gene in its natural form and 2 synthetic probes derived from it have also been used. A probe based on the delayed-type hypersensitive gene of L. monocytogenes requires further refinement before use. Both natural and synthetic β-listeriolysin probes have been used to enumerate L. monocytogenes in foods using colony hybridization with colonies grown on LPM (lithium chloride-phenylethanol-moxalactam) agar plates; 100% success rate has been obtained in enumerating L. monocytogenes in artificially contaminated milk and cheese. A DNA gene probe developed by GeneTrak has also been used with foods in a liquid hybridization assay after 48 h enrichment, but this technique is only genus specific and so does not differentiate between individual spp. of Listeria. Several different hybridization assays can be used for identification, but direct plating and colony hybridization are required for enumeration. The development of probes that can be detected by non-radioactive means would be welcome for analysis of foods, provided they gave the same degree of specificity and rapidity as radioactively labelled probes.
KW - biodeterioration
KW - cheeses
KW - Cows
KW - detection
KW - DNA
KW - DNA probes
KW - enumeration
KW - foods
KW - listeriosis
KW - milk
KW - Nucleic acids
KW - pathogens
KW - Techniques
KW - Bacteria
KW - cattle
KW - Listeria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Listeria
KW - bacterium
KW - deoxyribonucleic acid
KW - listerellosis
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920449757&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Outgrowth of Listeria monocytogenes in foods.
AU - Lovett, J.
AU - Francis, D. W.
AU - Bradshaw, J. G.
A2 - Miller, A. J.
A2 - Smith, J. L.
A2 - Somkuti, G. A.
T2 - Foodborne listeriosis: topics in industrial microbiology Volume 2.
Y1 - 1990///
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers, Journals Division
SN - 0444811869
AD - Lovett, J.: Food and Drug Administration, Cincinnati, OH, USA.
N1 - Accession Number: 19920449761. Publication Type: Book chapter. Language: English. Subject Subsets: Human Nutrition; Dairy Science
N2 - This paper describes studies that were undertaken into the growth of Listeria monocytogenes in trypticase soy broth-yeast extract broth at 30°C and in raw milk, pasteurized milk, meat and vegetables at 7°C. The authors conclude that L. monocytogenes grows well in most foods in the pH range 5.0-9.5 and at refrigeration temperatures; and that whole milk, raw or pasteurized, provides a poorer growth environment than meats, seafoods and vegetables.
KW - Cows
KW - foods
KW - growth
KW - listeriosis
KW - milk
KW - Pasteurized milk
KW - cattle
KW - Listeria
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - listerellosis
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920449761&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ozone-induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine.
AU - Banks, M. A.
AU - Porter, D. W.
AU - Martin, W. G.
AU - Castranova, V.
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
Y1 - 1991///
VL - 2
IS - 6
SP - 308
EP - 313
SN - 0955-2863
AD - Banks, M. A.: V. Castranova, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19921441492. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 107-35-7. Subject Subsets: Human Nutrition
N2 - Preincubation of alveolar macrophages from Sprague-Dawley rats in the presence of taurine resulted in a significant increase in the intracellular content of this nutrient. Ozone exposure was associated with further increases in free intracellular taurine content. This mobilization of taurine seems to be a defence response to oxidants, as taurine supplementation decreased oxidant injury resulting from exposure of these cells to ozone 0.45 mg/kg for 30 min. Results indicate that taurine enrichment (extracellular taurine 100, 250 or 500 µM) enhanced the ability of ozone-exposed cells to exclude trypan blue dye, decreased lipid peroxidation, lessened the ozone-induced decline in total ATPase and decreased the leakage of glutathione. Taurine supplementation also decreased protein leakage and reduced the ozone-induced decline in Na+/K+ ATPase but only with extracellular taurine 100 µM (i.e., the plasma value of this nutrient). Results suggest that taurine is mobilized from the bound to free state in response to ozone exposure and that it acts to protect alveolar macrophages from ozone-induced damage. The data are consistent with the theory that taurine acts as a membrane stabilizer and/or an antioxidant.
KW - Lipid peroxidation
KW - lungs
KW - macrophages
KW - taurine
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921441492&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The raw oyster consumer-a risk taker? Use of the behavioral risk factor surveillance system.
AU - Klontz, K. C.
AU - Desenclos, J. C. A.
AU - Wolfe, L. E.
AU - Hoecherl, S. A.
AU - Roberts, C.
AU - Gunn, R. A.
JO - Epidemiology
JF - Epidemiology
Y1 - 1991///
VL - 2
IS - 6
SP - 437
EP - 440
SN - 1044-3983
AD - Klontz, K. C.: Clinical Nutrition Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19931459325. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - The 1988 Behavioral Risk Factor Surveillance System [Public Health Reports (1988) 103, 366-375] was used in Florida to determine the prevalence of consumption of raw oysters a vehicle implicated in the transmission of several pathogens. One-third of the 1241 survey respondents reported ever eating raw oysters. The prevalence was higher for persons 18 to 49 years old and for men, and, when controlled for age and sex, for persons who reported being cigarette smokers or acute alcohol drinkers, and driving while intoxicated.
KW - intake
KW - Oysters
KW - raw foods
KW - risk
KW - USA
KW - Man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Diet Studies (VV110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459325&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food descriptions using taxonomy and the ′Langual′ system.
AU - Pennington, J. A. T.
AU - Butrum, R. R.
JO - Trends in Food Science & Technology
JF - Trends in Food Science & Technology
Y1 - 1991///
VL - 2
IS - 11
SP - 285
EP - 288
SN - 0924-2244
AD - Pennington, J. A. T.: The Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19921440612. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
N2 - Although the number of food composition databases in use throughout the world is increasing rapidly, there are still many problems concerning the sharing of compositional data among countries. Such problems may arise as a result of poor descriptions of foods listed in databases and as a result of confusion over the interpretation of commonly used names for foods. Alternative approaches for the description of and retrieval of information about foods, based on the ′Langual′ system and on taxonomic methods, are reviewed. The Langual system is based on the concept that foods listed in the database should have clear, concise descriptions using a number of facets. Taxonomic names for foods are a useful approach to identifying foods clearly and to assuring correct food identification when food names are translated to or from other languages.
KW - databases
KW - Food composition
KW - reviews
KW - data banks
KW - Information and Documentation (CC300)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921440612&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effects of dietary restriction and aging on in vivo and in vitro binding of aflatoxin B1 to cellular DNA.
AU - Chou, M. W.
AU - Pegram, R. A.
AU - Gao, P.
AU - Hansard, S. R.
AU - Shaddock, J. G.
AU - Casciano, D. A.
JO - Biomedical and Environmental Sciences
JF - Biomedical and Environmental Sciences
Y1 - 1991///
VL - 4
IS - 1-2
SP - 134
EP - 143
SN - 0895-3988
AD - Chou, M. W.: National Center for Toxicological Research, Jefferson, Arkansas, AR 72079, USA.
N1 - Accession Number: 19911210198. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology
N2 - Using aflatoxin B1 (AFB1) as a model carcinogen, in vivo and in vitro hepatic AFB1-DNA binding was studied, demonstrating that dietary restriction (60% of ad libitum consumption) may decrease the metabolic activation of AFB1 and subsequently reduce AFB1-DNA binding. Preliminary results obtained from AFB1-DNA binding experiments in isolated hepatocytes indicated that the observed age-dependent reduction in AFB1-DNA binding which may be attributed to a loss of metabolic activating capability was delayed in the diet-restricted rats.
KW - Aflatoxins
KW - aging
KW - binding
KW - diet
KW - DNA
KW - Mycotoxins
KW - poisoning
KW - susceptibility
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - deoxyribonucleic acid
KW - fungal toxins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210198&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A duplex cone trap for the collection of adult Aedes albopictus.
AU - Freier, J. E.
AU - Francy, D. B.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1991///
VL - 7
IS - 1
SP - 73
EP - 79
SN - 8756-971X
AD - Freier, J. E.: Division of Vector-Borne Infectious Diseases, Centers for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19910505331. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - A duplex cone trap was developed for the collection of adults of A. albopictus. This device employs carbon dioxide and a visual attractant to draw mosquitoes into an air current created by a 6-volt battery-powered fan. In comparison with 8 other adult mosquito traps (CDC gravid and light, dry ice, hamster-baited, horizontal and vertical tyre gravid, Malaise and Trinidad traps) tested in Louisiana, the duplex cone was most effective in capturing A. albopictus females. A greater diversity of mosquito species was caught in the duplex cone trap compared with the other traps tested. In an experiment comparing the duplex cone trap with human biting collections, this trap proved to be an efficient and sensitive means of monitoring A. albopictus population changes; A. albopictus accounted for 27.8% of cone trap collections made between 15 May and 29 June at Michoud, cf. Culex salinarius (25.3%), Coquillettidia perturbans (15.1%), A. triseriatus (11.4%) and A. atlanticus (9.2%).<new para>ADDITIONAL ABSTRACT:<new para>A duplex cone trap was developed for the collection of Aedes albopictus adults. This device employs carbon dioxide and a visual attractant to draw mosquitoes into an air current created by a 6-volt battery-powered fan. In comparison with 8 other adult mosquito traps, the duplex cone was most effective in capturing Ae. albopictus females. A greater diversity of mosquito species was caught in the duplex cone trap compared with the other traps tested. In an experiment comparing the duplex cone trap with human biting collections, this trap proved to be an efficient and sensitive means of monitoring Ae. albopictus population changes.AS
KW - Bait traps
KW - Equipment
KW - insect traps
KW - introduced species
KW - Light traps
KW - Malaise traps
KW - monitoring
KW - Population ecology
KW - Sampling
KW - Techniques
KW - trapping
KW - traps
KW - Louisiana
KW - North America
KW - USA
KW - Aedes
KW - Aedes albopictus
KW - Aedes atlanticus
KW - Aedes triseriatus
KW - Coquillettidia perturbans
KW - Culex salinarius
KW - Culicidae
KW - Diptera
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Coquillettidia
KW - Culex
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - West South Central States of USA
KW - Asian tiger mosquito
KW - cone traps
KW - duplex cone trap
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Ochlerotatus
KW - Ochlerotatus atlanticus
KW - Ochlerotatus triseriatus
KW - sampling techniques
KW - surveillance systems
KW - Tyre traps
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910505331&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of North and South American strains of Aedes albopictus for certain arboviruses: a review.
AU - Mitchell, C. J.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1991///
VL - 7
IS - 3
SP - 446
EP - 451
SN - 8756-971X
AD - Mitchell, C. J.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 207, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19920507933. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Since the introduction of A. albopictus into North and South America, 18 viruses in 3 families (Flaviviridae, Togaviridae, Bunyaviridae) have been used in vector competence studies involving 10 North American (USA) and 4 South American (Brazil) geographic strains of A. albopictus. This review summarizes the results of these studies and discusses the potential of A. albopictus to become a vector of arboviruses of public health importance in areas of the Western Hemisphere where it has recently become established.
KW - arboviruses
KW - disease transmission
KW - disease vectors
KW - Infection
KW - introduced species
KW - Reviews
KW - Transmission
KW - vector competence
KW - vectors
KW - America
KW - Brazil
KW - North America
KW - South America
KW - USA
KW - Aedes albopictus
KW - Alphavirus
KW - Bunyaviridae
KW - Chikungunya virus
KW - Culicidae
KW - Dengue virus
KW - Diptera
KW - Eastern equine encephalitis virus
KW - Flaviviridae
KW - Flavivirus
KW - Jamestown Canyon virus
KW - La Crosse virus
KW - Mayaro virus
KW - Oropouche virus
KW - Orthobunyavirus
KW - Phlebovirus
KW - Rift Valley fever virus
KW - Ross River virus
KW - Togaviridae
KW - Trivittatus virus
KW - Venezuelan equine encephalitis virus
KW - Western equine encephalitis virus
KW - Yellow fever virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - negative-sense ssRNA viruses
KW - Alphavirus
KW - Flavivirus
KW - Flaviviridae
KW - equine encephalomyelitis virus
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - Phlebovirus
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - America (North)
KW - America (South)
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - Bunyavirus
KW - competence
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - Keystone virus
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - North and South America
KW - Potosi virus
KW - United States of America
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920507933&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anopheles gambiae as a host for geographic isolates of Plasmodium vivax.
AU - Collins, W. E.
AU - Roberts, J. M.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1991///
VL - 7
IS - 4
SP - 569
EP - 573
SN - 8756-971X
AD - Collins, W. E.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920508987. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2 - The G-3 strain of A. gambiae (originally from The Gambia) was compared with 2 other strains of A. gambiae (KWA from Tanzania and ZAN from Zanzibar) and A. freeborni F-1 (from California), A. stephensi (from India) and A. dirus (from Thailand) for susceptibility to infection with 7 different geographic strains of P. vivax (i.e. Salvador I, North Korean, Chesson, New Guinea I/OCDC, ONG/CDC, NAM/CDC and Indochina I/CDC). Ratios of infection varied, indicating that certain strains of P. vivax were more infectious to the G-3 strain of A. gambiae than to other anopheline species/strains. Based on the comparative number of oocysts per mosquito, the relationships between the 3 strains of A. gambiae were closer than between the G-3 strain of A. gambiae and the 3 other species of Anopheles. A. gambiae appears to be a very useful host for laboratory studies with P. vivax from different geographic origins.<new para>ADDITIONAL ABSTRACT:<new para>The G-3 strain of Anopheles gambiae was compared with 2 other strains of An. gambiae and An. freeborni, An. stephensi, and An. dirus for susceptibility to infection with 7 different geographic strains of Plasmodium vivax. Ratios of infection varied, indicating that certain strains of P. vivax were more infectious to the G-3 strain of An. gambiae than to other anopheline species/strains. Based on the comparative number of oocysts per mosquito, the relationships between the 3 strains of An. gambiae were closer than between the G-3 strain of An. gambiae and the 3 other species of Anopheles. Anopheles gambiae appears to be a very useful host for laboratory studies with P. vivax from different geographic origins.AS
KW - disease vectors
KW - Human diseases
KW - infection
KW - parasites
KW - susceptibility
KW - Vector competence
KW - Vectors
KW - Cambodia
KW - El Salvador
KW - Indonesia
KW - Korea Democratic People's Republic
KW - Papua New Guinea
KW - Thailand
KW - Anopheles
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - Plasmodiidae
KW - Plasmodium vivax
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Protozoa
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - Indochina
KW - South East Asia
KW - Asia
KW - Least Developed Countries
KW - Developing Countries
KW - CACM
KW - Central America
KW - America
KW - Latin America
KW - APEC countries
KW - ASEAN Countries
KW - East Asia
KW - ACP Countries
KW - Commonwealth of Nations
KW - New Guinea
KW - Melanesia
KW - Australasia
KW - Oceania
KW - Pacific Islands
KW - Kampuchea
KW - Khmer Republic
KW - mosquitoes
KW - North Korea
KW - Salvador
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920508987&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The protective role of humoral neutralizing antibody in the NIH potency test for rabies vaccines.
AU - Wunderli, P. S.
AU - Shaddock, J. H.
AU - Schmid, D. S.
AU - Miller, T. J.
AU - Baer, G. M.
JO - Vaccine
JF - Vaccine
Y1 - 1991///
VL - 9
IS - 9
SP - 638
EP - 642
SN - 0264-410X
AD - Wunderli, P. S.: Division of Viral and Rickettsial Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19912255229. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Intraperitoneal vaccination of mice with rabies vaccine results in both dosage-dependent rabies virus neutralizing antibody titres and protection from lethal intracerebral (i.c.) challenge with fixed strain CVS rabies virus. Pre-exposure adoptive i.v. transfer of naive or immune cells did not protect naive Balb/c mice from lethal i.c. CVS challenge, but immune serum and anti-rabies glycoprotein monoclonal antibodies (individually and in combination) did not confer protection when injected before or up to 24 h after lethal i.c. rabies virus challenge.
KW - quality controls
KW - Rabies
KW - vaccines
KW - viral diseases
KW - Virus neutralization
KW - USA
KW - Mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - quality assurance
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912255229&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Behavioral assessment of rats fed a high carbohydrate/low protein meal.
AU - Sobotka, T.
AU - Brodie, R.
AU - Quander, Y.
AU - Kopral, C.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1991///
VL - 11
IS - 2/3
SP - 207
EP - 216
SN - 0271-5317
AD - Sobotka, T.: Food and Drug Administration (HFF-162), 200 C St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19911433821. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - A profile of behaviours was assessed in male Sprague-Dawley rats fed a single meal of a protein-free diet with an increased level of carbohydrate. Rats, fasted for 24 h, were given a 2-h meal of a control AIN-76A diet or an isoenergetic diet containing about 85% carbohydrate and 0% protein. Rats were tested for general motor activity, auditory startle, prepulse inhibition of the startle response, tail flick response, passive avoidance acquisition and retention, or response to pharmacological challenge with a dopaminergic or a serotonergic agonist. None of the behavioural estimations were significantly affected by dietary treatment. Data suggest that high carbohydrate, protein-free meals do not significantly affect sensorimotor behaviours, reactivity, or cognitive functions of the nervous system.
KW - Behaviour
KW - nutritive ratio
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - energy protein ratio
KW - protein energy ratio
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911433821&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of foodborne pathogens by nucleic acid hybridization.
AU - Hill, W. E.
AU - Keasler, S. P.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 1991///
VL - 12
IS - 1
SP - 67
EP - 75
SN - 0168-1605
AD - Hill, W. E.: Molecular Biology Branch, Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19910448424. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 9007-49-2. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - Nucleic acid hybridization methods have been developed and used to identify microorganisms (e.g. Escherichia coli, Salmonella, Listeria monocytogenes, Yersinia enterocolitica) in foods. Tests performed on mixed cultures save the time required to establish pure cultures. Enterotoxigenic or invasive strains of foodborne bacterial pathogens are detected with probes that identify genes responsible for virulence. Hybridization tests signal the presence or absence of a particular strain or an entire genus and are especially well suited for screening foods for specific pathogens. With the colony hybridization assay format, foodborne bacteria harbouring a specific gene can be enumerated. However, hybridization tests require the presence of 105 to 106 cells to yield a positive result, thereby limiting sensitivity and necessitating a time-consuming growth step. In vitro DNA amplification techniques increase the amount of DNA segments 105-106-fold in 2 to 3 h, thus enhancing test sensitivity.
KW - biodeterioration
KW - detection
KW - DNA
KW - foods
KW - hybridization
KW - Nucleic acids
KW - pathogens
KW - Bacteria
KW - Escherichia coli
KW - Listeria monocytogenes
KW - Salmonella
KW - Yersinia enterocolitica
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Yersinia (Bacteria)
KW - bacterium
KW - deoxyribonucleic acid
KW - E. coli
KW - Food Science and Food Products (Human) (QQ000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910448424&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of iodine derivatives of aflatoxin B1 and G1 by thermospray mass spectrometry.
AU - Holcomb, M.
AU - Korfmacher, W. A.
AU - Thompson, H. C., Jr.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 1991///
VL - 15
IS - 6
SP - 289
EP - 292
SN - 0146-4760
AD - Holcomb, M.: Department of Health and Human Services, Public Health Services, Food and Drug Administration, National Center for Toxicological Research, Office of Research Services, Division of Chemistry & Division of Biochemical Toxicology, Jefferson, AR 72079, USA.
N1 - Accession Number: 19921211644. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology
N2 - Thermospray mass spectrometry (TSMS) was used to identify the derivatives formed when iodine is reacted with aflatoxins B1 and G1 at approx. 70°C to enhance fluorescence. It was found that stable derivatives were formed by addition of an iodine atom and a methoxy group across the double bond located on the furan ring of the aflatoxin B1 and G1 molecules. TSMS and TSMS/MS daughter spectra of the reaction products of aflatoxin B1 and G1 with iodine provided evidence of the addition of each moiety to produce the iodo-methoxy derivative. The addition of an iodine atom to one carbon and a methoxy group to the other carbon of the furan ring provided molecular weights of 470 and 486 for the products of aflatoxin B1 and G1, respectively.
KW - Aflatoxins
KW - detection
KW - fluorescence
KW - Mycotoxins
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211644&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lyme borreliosis: ten years after discovery of the etiologic agent, Borrelia burgdorferi.
AU - Burgdorfer, W.
JO - Infection
JF - Infection
Y1 - 1991///
VL - 19
IS - 4
SP - 257
EP - 262
SN - 0300-8126
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1 - Accession Number: 19950800132. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Since the recovery of its causative agent, B. burgdorferi, in 1981, Lyme borreliosis has become the most prevalent tickborne disease in the USA and Europe. The incidence of reported cases in the USA has increased from 2000 cases in 1987 to over 8000 in 1989. It occurs now in regions where the tick vectors, Ixodes dammini [I. scapularis] and I. pacificus, are absent and where other species of ticks may be responsible for maintaining and distributing the spirochaete. In Europe, Lyme borreliosis has been reported from 19 countries; its occurrence coincides with the distribution of I. ricinus. Specific and dependable serological tests are still not available, but development of probes for specific antigens and the polymerase chain reaction appear promising in detecting ongoing infection and in the identification of B. burgdorferi. Brief mention is made of advances in the development of whole cell and genetically engineered vaccines.
KW - disease vectors
KW - human diseases
KW - immunodiagnosis
KW - Lyme disease
KW - reviews
KW - tickborne diseases
KW - vaccines
KW - Europe
KW - USA
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Ixodidae
KW - man
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - lyme borreliosis
KW - serological diagnosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950800132&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of the Australian paralysis tick, Ixodes holocyclus, for the Lyme disease spirochete Borrelia burgdorferi.
AU - Piesman, J.
AU - Stone, B. F.
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 1991///
VL - 21
IS - 1
SP - 109
EP - 111
SN - 0020-7519
AD - Piesman, J.: Division of Vector-borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Ft Collins, CO 80522, USA.
N1 - Accession Number: 19910505795. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Clinical and serologic evidence of Lyme disease in Australia, including the typical rash, erythema migrans, has been reported [e.g. Medical Journal of Australia, 144: 724-725 (1986); ibid., 145: 364 (1986)]. The vector tick transmitting B. burgdorferi in Australia, however, has not been determined. I. holocyclus is a 'logical' candidate vector of the Lyme disease spirochaete in Australia; therefore, the ability of I. holocyclus to acquire and maintain a North American isolate of B. burgdorferi was tested. Larval I. holocyclus ingested spirochaetes, but none of 84 derived nymphs were infected. These experiments need to be repeated with Australian strains of spirochaetes.<new para>ADDITIONAL ABSTRACT:<new para>Clinical and serologic evidence of Lyme disease in Australia, including the typical rash, erythema migrans, has been reported. The vector tick transmitting Borrelia burgdorferi in Australia, however, has not been determined. The Australian paralysis tick, Ixodes holocyclus, is a logical candidate vector of the Lyme disease spirochete in Australia; therefore, [the authors] tested the ability of I. holocyclus to acquire and maintain a North American isolate of B. burgdorferi. Larval I. holocyclus ingested spirochetes, but none of 84 derived nymphs were infected. These experiments should be repeated with Australian strains of spirochetes.AS/B.R. Laurence
KW - disease transmission
KW - disease vectors
KW - Epidemiology
KW - Infection
KW - Lyme disease
KW - Transmission
KW - vector competence
KW - vectors
KW - Australia
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Ixodes
KW - Ixodes holocyclus
KW - Ixodidae
KW - Metastigmata
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - bacterium
KW - holocyclus
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910505795&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nasal and retrobulbar mass in a cat caused by Pythium insidiosum.
AU - Bissonnette, K. W.
AU - Sharp, N. J. H.
AU - Dykstra, M. H.
AU - Robertson, I. R.
AU - Davis, B.
AU - Padhye, A. A.
AU - Kaufman, L.
JO - Journal of Medical and Veterinary Mycology
JF - Journal of Medical and Veterinary Mycology
Y1 - 1991///
VL - 29
IS - 1
SP - 39
EP - 44
SN - 0268-1218
AD - Bissonnette, K. W.: A. A. Padhye, Division of Bacterial and Mycotic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19911208842. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 65277-42-1. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology; Veterinary Science
N2 - A case of nasal and retrobulbar infection caused by P. insidiosum is reported in a 3-yr-old male, domestic, shorthaired cat. The diagnosis was established on 3 criteria: the staining of broad, sparsely septate hyphal elements in biopsy tissue using a fluorescein-labelled antiglobulin specific for P. insidiosum, detection of antibodies to P. insidiosum by an immunodiffusion test, and isolation of the aetiological agent in pure culture from the biopsy tissue. Treatment with oral ketoconazole (10 mg/kg twice daily) for 6 wks resulted in clinical improvement, but proptosis of the left eye slowly appeared after the discontinuation of treatment.
KW - Antifungal agents
KW - Case reports
KW - cat diseases
KW - eyes
KW - hosts
KW - infections
KW - Ketoconazole
KW - Mycoses
KW - nose
KW - USA
KW - Cats
KW - Pythiaceae
KW - Pythium
KW - Pythium insidiosum
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pythiaceae
KW - Pythiales
KW - Oomycetes
KW - Oomycota
KW - Mastigomycotina
KW - fungi
KW - Pythium
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungistats
KW - fungus
KW - Peronosporomycetes
KW - Straminipila
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911208842&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Manufacturing processes at two French rapeseed oil companies: possible relationships to toxic oil syndrome in Spain.
AU - Paz, M. P. de la
AU - Philen, R. M.
AU - Borda, I. A.
AU - Bernert, J. T., Jr.
AU - Gancedo, J. C. B.
AU - DuClos, P. J.
AU - Kilbourne, E. M.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1991///
VL - 29
IS - 12
SP - 797
EP - 803
SN - 0278-6915
AD - Paz, M. P. de la: Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19931460618. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - To examine possible contaminants and modes of contamination, the workings of 2 French companies that processed rapeseed oil and who were identified as exporting aniline-denatured rapeseed oil to Spain in 1981 when the toxic oil syndrome epidemic occured are studied.
KW - Food contamination
KW - oils
KW - Spain
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931460618&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy of the immunoblot assay for cysticercosis in pigs and modulated expression of distinct IgM/IgG activities to Taenia solium antigens in experimental infections.
AU - Tsang, V. C. W.
AU - Pilcher, J. A.
AU - Zhou, W.
AU - Boyer, A. E.
AU - Kamango-Sollo, E. I. P.
AU - Rhoads, M. L.
AU - Murrell, D.
AU - Schantz, P. M.
AU - Gilman, R. H.
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
Y1 - 1991///
VL - 29
IS - 1-2
SP - 69
EP - 78
SN - 0165-2427
AD - Tsang, V. C. W.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19922260711. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 308067-57-4. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science; Helminthology
N2 - A recently invented immunoblot assay for human cysticercosis was evaluated for efficacy in pigs. The test population consisted of 45 pigs with parasitologically confirmed cysticercosis, 47 with heterologous infections, 45 SPF or concrete raised control animals. With this group of 137 animals the test performance was 100% sensitive and 100% specific. The antigen-specific responses of immunoglobulin A (IgA), IgG and IgM in 4 pigs infected with Taenia solium eggs derived from a human were quantified by immunoblot. Antigen-specific activities were observed as early as 1 week after infection. The first antigen-specific isotypic response was IgM antibodies directed against a glycoprotein at 97 KD (GP97). This activity generally disappeared between the sixth and ninth week after infection. Between weeks 5 and 8, IgG activity rose as IgM activity fell. The IgG activity, however, was directed mostly towards GP50 and GP42 antigens. It was concluded that if the same response occurs in people with cysticercosis, identifying specific isotype activity may help to distinguish new infection from old.
KW - Cysticercosis
KW - Diagnosis
KW - epitopes
KW - helminths
KW - Immune response
KW - immunoblotting
KW - immunodiagnosis
KW - Immunoglobulins
KW - Immunological techniques
KW - Livestock
KW - metacestodes
KW - parasites
KW - swine diseases
KW - Artiodactyla
KW - Cestoda
KW - pigs
KW - Suidae
KW - Taenia solium
KW - Taeniidae
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Platyhelminthes
KW - invertebrates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Taenia
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - antigenic determinants
KW - gamma-globulins
KW - hogs
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - parasitic worms
KW - pig diseases
KW - pork tapeworm
KW - serological diagnosis
KW - serological techniques
KW - swine
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Host Resistance and Immunity (HH600)
KW - Techniques and Methodology (ZZ900)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of trace level residues in the food supply.
AU - Cairns, T.
AU - Siegmund, E. G.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1991///
VL - 30
IS - 3
SP - 397
EP - 402
SN - 1040-8398
AD - Cairns, T.: Department of Health and Human Services, Food and Drug Administration, Los Angeles, CA, USA.
N1 - Accession Number: 19931457025. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition; Postharvest Research
N2 - Estimation of trace residues of contaminants in the range of low parts per million to parts per trillion by mass spectrometric methods is reviewed. At such values various data manipulations or alternate choices of approaching the analytical problem of confirmation must be employed to ensure an acceptable result. The problems experienced when dealing with ng values in analysis are much more complex than when recording a mass spectrum of an ample supply of a reference standard. This review reflects an interpretation of the developing status of confirmation since "accepted criteria" do not yet exist.
KW - Aflatoxins
KW - contamination
KW - estimation
KW - Food contamination
KW - Foods
KW - mycotoxins
KW - reviews
KW - food contaminants
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931457025&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of aflatoxins (B1, B2, G1, and G2) in rodent feed by HPLC using postcolumn derivatization and fluorescence detection.
AU - Holcomb, M.
AU - Thompson, H. C., Jr.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1991///
VL - 39
IS - 1
SP - 137
EP - 140
SN - 0021-8561
AD - Holcomb, M.: Department of Health and Human Services, Public Health Service, Food and Drug Administration, Office of Research Services, Division of Chemistry, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19911209686. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition
N2 - An existing method was modified for application to the analysis of aflatoxins in vitamin-fortified rodent feeds. The aflatoxins were extracted from the feeds with 70% methanol/water followed by cleanup on an affinity column. The aflatoxins were eluted from the affinity column with methanol and quantitated via HPLC using postcolumn derivatization with iodine followed by fluorescence detection. The minimum detectable limit was 0.25 p.p.b. for B1, B2 and G1 and 0.12 p.p.b. for G2. Recoveries for B1 and G1 averaged 85% over a concn range of 0.5-50 p.p.b. Recoveries for B2 averaged 77% over the same range, while recoveries for G2 averaged 58% over a concn range of 0.25-25 p.p.b. The method was also successfully used for analysis of aflatoxins in animal cage bedding material.
KW - Aflatoxins
KW - analytical methods
KW - biodeterioration
KW - contamination
KW - estimation
KW - feeds
KW - liquid chromatography
KW - litter
KW - Mycotoxins
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - feeding stuffs
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with human immunodeficiency virus.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1991///
VL - 40
IS - 2
SP - ii + 13
EP - ii + 13
SN - 0149-2195
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Infectious Diseases, Division of HIV/AIDS, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920800427. Publication Type: Annual report. Corporate Author: USA, Working group on PCP prophylaxis in children. Language: English. Number of References: 63 ref. Subject Subsets: Protozoology
N2 - This report summarizes deliberations and guidelines provided by experts in paediatric HIV infection (convened by the Paediatric HIV Resource Center); who independently reviewed recent data, and provided recommendations to the U.S. Public Health Service for P. carinii pneumonia (PCP) prophylaxis for HIV-infected or -exposed children. The report is presented under the headings: impact of PCP on HIV-infected children; problems in defining the paediatric population appropriate for prophylaxis; CD4+ cell count and PCP among HIV-infected children; regimens for PCP prophylaxis for HIV-infected or -exposed children; trimethoprim-sulfamethoxazole; aerosolized pentamidine; dapsone; parenteral pentamidine; patient evaluation; recommended chemoprophylaxis regimen; alternative regimens; and future needs.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Antiprotozoal agents
KW - Children
KW - Human diseases
KW - human immunodeficiency viruses
KW - Immunocompromised hosts
KW - Opportunistic infections
KW - parasites
KW - Pneumonia
KW - prophylaxis
KW - reviews
KW - USA
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - protozoa
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - fungus
KW - human immunodeficiency virus
KW - United States of America
KW - US Department of Health and Human Services
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920800427&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mosquito-transmitted malaria - California and Florida, 1990.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1991///
VL - 40
IS - 6
SP - 106
EP - 108
SN - 0149-2195
AD - US Department of Health and Human Services/Public Health Service.
N1 - Accession Number: 19940803426. Publication Type: Journal Article. Corporate Author: Centers for Disease Control Language: English. Number of References: 3 ref. Subject Subsets: Protozoology
N2 - In 1990, two persons - one each in California and Florida - were diagnosed with Plasmodium vivax malaria that was thought to have been transmitted through bites of mosquitoes that became infected after biting parasitaemic migrant workers. In each case, competent mosquito vectors were identified in the locality (Anopheles hermsi in California and A. quadrimaculatus in Florida). This report describes the 2 cases and an editorial note discusses the epidemiology of imported malaria.
KW - case reports
KW - parasites
KW - transmission
KW - California
KW - Florida
KW - USA
KW - Anopheles hermsi
KW - Anopheles quadrimaculatus
KW - Culicidae
KW - man
KW - Plasmodium vivax
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803426&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of folic acid for prevention of spina bifida and other neural tube defects - 1983-1991.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1991///
VL - 40
IS - 30
SP - 513
EP - 516
SN - 0149-2195
AD - Public Health Service, Centers for Disease Control, Atlanta, GA 30333, USA.
N1 - Accession Number: 19921447644. Publication Type: Journal Article. Corporate Author: US Department of Health and Human Services. Language: English. Number of References: 13 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
N2 - A study of folate supplementation in women who had a previous pregnancy that resulted in an infant or foetus with a neural tube defect, involving 33 centres (17 in the UK and 16 in 6 other countries) from July 1983 to April 1991 is described. Women were randomly assigned to 4 groups: group 1, folic acid 4 mg; group 2, a multivitamin preparation + folic acid 4 mg; group 3, neither the multivitamin nor folic acid supplement; group 4, multivitamin preparation without folic acid. Neural tube defects recurred in 6 (1%) of 593 infants or foetuses of women in groups 1 and 2, compared with 21% (3.5%) of 602 women in groups 3 and 4. Therefore, folic acid supplementation was associated with a 71% reduction in recurrence. Use of multivitamins without folic acid was not associated with a significant protective effect. Interim recommendations for folic acid supplementation by the Centers for Disease Control, USA for women who have had an infant or foetus with a neural tube defect are presented.
KW - congenital abnormalities
KW - Fetus
KW - folic acid
KW - Infants
KW - mothers
KW - nervous system
KW - supplements
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth defects
KW - congenital malformations
KW - foetus
KW - folacin
KW - folate
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921447644&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - St Louis encephalitis outbreak - Arkansas, 1991.
AU - Townsend, T. E.
AU - Bishop, T. P.
AU - Higdem, B. D.
AU - Lofgren, J. P.
AU - McChesney, T. C.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1991///
VL - 40
IS - 35
SP - 605
EP - 607
SN - 0149-2195
AD - Townsend, T. E.: US Department of Health and human Services/Public Health Service.
N1 - Accession Number: 19940806277. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - On August 2nd, 1991, a neurologist in Pine Bluff, central Arkansas, USA, notified the Arkansas Department of Health of 2 patients hospitalized with St Louis encephalitis (SLE). A hospital chart review and heightened surveillance subsequently identified 24 confirmed or probable cases of SLE. This report summarizes the findings of the outbreak investigation. An intensive spraying campaign was mounted to control Culex quinquefasciatus, the suspected mosquito vector. In an editorial note, SLE is described as the leading cause of epidemic viral encephalitis in the USA. Outbreaks occur at approximately 10-year intervals. The epidemiology of SLE is discussed.<new para>ADDITIONAL ABSTRACT:<new para>An outbreak of St Louis encephalitis, the leading cause of epidemic viral encephalitis in the USA ( with less than 1% of cases clinically apparent), was detected at the beginning of August 1991. By the time of this report about 5 weeks later 16 confirmed and 8 probable cases had been identified; all were in people who lived or worked in Pine Bluff, central Arkansas. Three have residual neurologic defects and one (with leukaemia) died; the attack rate was 39/105 population. Preventive measures were urged and publicized, and spraying was begun to control Culex quinquefasciatus. (An editorial note describes previous outbreaks.)D.W. FitzSimons
KW - arboviruses
KW - epidemiology
KW - human diseases
KW - infections
KW - outbreaks
KW - St Louis encephalitis
KW - viral diseases
KW - Arkansas
KW - USA
KW - Culicidae
KW - Diptera
KW - Flavivirus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Flavivirus
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West South Central States of USA
KW - America (North)
KW - arthropod-borne viruses
KW - mosquitoes
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940806277&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spinal dracunculiasis in an experimentally infected ferret.
AU - Broderson, J. R.
AU - Eberhard, M. L.
AU - Welch, B. G.
AU - Bandt, F. H.
JO - Laboratory Animal Science
JF - Laboratory Animal Science
Y1 - 1991///
VL - 41
IS - 2
SP - 180
EP - 182
SN - 0023-6764
AD - Broderson, J. R.: Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control (Mailstop F.33), Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920881374. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Helminthology
N2 - Twenty-five ferrets were inoculated with infective Dracunculus insignis larvae by oral administration of infected cyclops. At 196 days pi, one of the ferrets developed paresis in the hind limbs, which progressed over the next 4 days to complete paraplegia. The ferret had been placed randomly into a group that received metrifonate (20 mg/kg) on day 60 pi. Special examination of the central nervous system (CNS) at necropsy revealed a large, gravid female worm in the subdural space, coiled around the spinal cord. Microscopically, the worm had caused compression of the spinal cord and malacia, with regionally diffuse haemorrhage and inflammation. The parasite was seen penetrating into the cauda equina, closely associated with the roots of the lower spinal nerves. This is believed to be the first time that aberrant migration of Dracunculus into the CNS has occurred in a ferret.
KW - central nervous system
KW - disease models
KW - experimental infections
KW - helminths
KW - laboratory animals
KW - parasites
KW - pathology
KW - carnivores
KW - Dracunculidae
KW - Dracunculus insignis
KW - ferrets
KW - Mustelidae
KW - Nematoda
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Dracunculus
KW - Dracunculidae
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - CNS
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920881374&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.
AU - Richards, F. O., Jr.
AU - Eberhard, M. L.
AU - Bryan, R. T.
AU - McNeeley, D. F.
AU - Lammie, P. J.
AU - McNeeley, M. B.
AU - Bernard, Y.
AU - Hightower, A. W.
AU - Spencer, H. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1991///
VL - 44
IS - 1
SP - 3
EP - 10
SN - 0002-9637
AD - Richards, F. O., Jr.: Division of Parasitic Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19910872025. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 90-89-1, 1642-54-2, 70288-86-7. Subject Subsets: Helminthology; Tropical Diseases
N2 - This 3-phase study was designed to compare high dose ivermectin with a standard diethylcarbamazine (DEC) regimen for patient tolerability, potential to kill adult filaria, and duration of microfilarial suppression in 30 Haitian subjects with Wuchereria bancrofti microfilaraemia. All were first given a one mg oral dose of ivermectin (phase I) to reduce microfilaria densities. Participants were randomized into 3 groups: Group 1 received DEC (6 mg/kg/day for 12 days), Group 2 received 200 µg/kg of ivermectin, and Group 3 received 400 µg/kg of ivermectin (200 µg/kg/day for 2 days). All drug regimens were well tolerated with few adverse reactions. Most reactions occurred during phase I and consisted primarily of headache, fever and myalgia. At the end of phase I, 27 of 30 (90%) patients were microfilaria negative. During phase II, 4 of the 6 men receiving DEC developed scrotal reactions suggesting killing of adult worms; no such reactions were noted in 10 men receiving ivermectin. At one-year follow up (phase III), all treatment groups had less than 10% return to pretreatment microfilaria levels. The mean percent of baseline microfilaria counts were for Group 1, 0.9% (range 0-5%); Group 2, 8.2% (range 0-31%); and Group 3, 3.8% (range 0-25%). Seven individuals in Group 1 were microfilaria-negative, whereas only one and 3 individuals were microfilaria-negative in Groups 2 and 3, respectively. These results suggest that DEC causes more damage to the adult worms and greater reduction in microfilaria densities than does ivermectin, but that high doses of ivermectin may suppress microfilaraemia in lymphatic filariasis for periods much longer than previously reported.<new para>ADDITIONAL ABSTRACT:<new para>This paper describes the effects of diethylcarbamazine (DEC) and ivermectin on human Wuchereria bancrofti infection. In particular, the tolerability of the drugs, the effect on adult parasites and the duration of microfilarial suppression were examined. Thirty infected Haitians were given a small (1 mg) dose of ivermectin; this dose cleared microfilaraemia in 90% of the patients at day 5 but caused adverse reactions, mostly mild flu-like symptoms, in 90% of the subjects. They were then blindly randomized to 1 of the 3 treatment regimens: DEC (72 mg/kg over 12 days) or ivermectin (single dose, or 2 doses 24 h apart, of 200 µg/kg). Those receiving DEC suffered significantly more clinical reactions, particularly headaches and scrotal reactions, but had significantly lower microfilarial levels 9 and 12 months after treatment than the ivermectin groups. The authors conclude that DEC causes more damage to adult parasites than ivermectin, although it is noted that microfilarial levels were considerably higher in the ivermectin groups than the DEC group before treatment. Ivermectin appears to have caused a longer period of microfilarial suppression in this study than in previous ones, but the densities of the infections before treatment in the other studies are not presented. The authors conclude that ivermectin may have had some action on adult parasites, the discrepancy with other studies may have arisen because of the regimens used, or because of geographical variation in the parasites.J. Whitworth
KW - Anthelmintics
KW - bancroftian filariasis
KW - comparisons
KW - Diethylcarbamazine
KW - drug therapy
KW - filariasis
KW - Filariids
KW - helminths
KW - Human diseases
KW - ivermectin
KW - parasites
KW - treatment
KW - Caribbean
KW - Haiti
KW - man
KW - Nematoda
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Wuchereria
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - chemotherapy
KW - high dose
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910872025&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of the health claims regulations: the case of omega-3 fatty acids and heart disease.
AU - Wallingford, J. C.
AU - Yetley, E. A.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1991///
VL - 49
IS - 11
SP - 323
EP - 331
SN - 0029-6643
AD - Wallingford, J. C.: Clinical Nutrition Branch, Division of Nutrition, Food and Drug Administration, 200 C Street, Washington, DC 20204, USA.
N1 - Accession Number: 19931455128. Publication Type: Journal Article. Language: English. Number of References: 80 ref. Subject Subsets: Human Nutrition
N2 - This paper is an invited review of the scientific basis for the regulations being proposed by the Food and Drug Administration of the USA with respect to health claims for dietary supplements of ω-3 fatty acids in reducing the risk of coronary heart disease.
KW - Heart diseases
KW - polyenoic fatty acids
KW - reviews
KW - supplements
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - coronary diseases
KW - polyunsaturated fatty acids
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931455128&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health implications of obesity in American Indians and Alaska Natives.
AU - Welty, T. K.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1991///
VL - 53
IS - Suppl 6
SP - 1616
EP - 1620
SN - 0002-9165
AD - Welty, T. K.: Epidemiology Program, Aberdeen Area Indian Health Service, 3200 Canyon Lake Drive, Rapid City, SD 57702, USA.
N1 - Accession Number: 19921442705. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - American Indians and Alaska Natives (AI/ANs) are experiencing an epidemic of diabetes, increasing rates of coronary artery disease and hypertension, and poor survival rates for breast cancer that are likely partly attributable to the increasing prevalence of obesity over the past generation. Obesity may also contribute to the high rates of gallstones and to adverse outcomes of pregnancy in AI/ANs. Although overall mortality was not associated with obesity in Pima Indians (except in the most obese men), the relation of obesity to longevity in other AI/AN groups is not known. Further study of the specific health effects of obesity in various groups of AI/ANs are needed. Community-based programmes to prevent obesity and its sequelae should be implemented in all AI/AN communities.
KW - Ethnic groups
KW - health
KW - obesity
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442705&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Obesity prevention.
AU - Jackson, M. Y.
AU - Proulx, J. M.
AU - Pelican, S.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1991///
VL - 53
IS - Suppl 6
SP - 1625
EP - 1630
SN - 0002-9165
AD - Jackson, M. Y.: Nutrition and Dietetics Section, Indian Health Service, 5600 Fishers Lane, Room 6A-38, Rockville, MD 20857, USA.
N1 - Accession Number: 19921442707. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition
N2 - Given the increased risk of overweight and the fact that many weight-related behaviours acquired during childhood and adolescence are likely to be maintained into adulthood, minority teenagers are a key group to target for obesity-prevention efforts. 3 theoretical elements of behaviour change in relation to obesity-related knowledge, attitudes and food behaviours of minority groups in the US are discussed and the status of individual-, family-, school- and environment-based efforts to prevent or treat obesity in minority adolescents are summarized.
KW - Adolescents
KW - children
KW - obesity
KW - prevention
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - teenagers
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442707&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of obesity in American Indians and Alaska Natives.
AU - Broussard, B. A.
AU - Johnson, A.
AU - Himes, J. H.
AU - Story, M.
AU - Fichtner, R.
AU - Hauck, F.
AU - Bachman-Carter, K.
AU - Hayes, J.
AU - Frohlich, K.
AU - Gray, N.
AU - Valway, S.
AU - Gohdes, D.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1991///
VL - 53
IS - Suppl. 6
SP - 1535
EP - 1542
SN - 0002-9165
AD - Broussard, B. A.: Indian Health Service Diabetes Program, US Public Health Service, Albuquerque, NM, USA.
N1 - Accession Number: 19921442741. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Human Nutrition
N2 - Because American Indians are not represented in most national health and nutrition surveys, there is a lack of data on actual prevalence of obesity in American Indians. Prevalence of overweight and obesity was estimated for American Indian adults, school-age children and preschool children from existing data. The prevalence of obesity in adults was estimated from self-reported weights and heights obtained from a special survey of American Indians performed as part of the 1987 National Medical Expenditure Survey. Prevalence of obesity in American Indians was 13.7% for men and 16.5% for women, which was higher than the US rates of 9.1 and 8.2%, respectively. Obesity rates in American Indian adolescents and preschool children were higher than the respective rates for US all-races combined.
KW - Ethnic groups
KW - incidence
KW - obesity
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442741&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative comparison of two enrichment methods for isolating Listeria monocytogenes from seafoods.
AU - Lovett, J.
AU - Francis, D. W.
AU - Peeler, J. T.
AU - Twedt, R. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 1
SP - 7
EP - 11
SN - 0362-028X
AD - Lovett, J.: Division of Microbiology, Food and Drug Administration, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19911367491. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition
N2 - Two enrichment methods that had been used as standard procedures by the US Food and Drug Administration (FDA) and the USDA were quantitatively compared for their ability to isolate L. monocytogenes from seafoods. Cultures of a clinical sample and a seafood isolate were inoculated into raw and cooked shrimp; cultures heated at 57.8°C for 5 min were added to surimi, cooked crab meat and cooked shrimp. With the FDA procedure, which used enrichment intervals of 24 h, 48 h and 7 d, KOH culture treatment and enrichment for 24 h provided no advantage for Listeria recovery. The FDA procedure isolated heated L. monocytogenes from seafoods at a lower level than the USDA method; however, both methods isolated unheated cells equally well. The greater selectivity of the USDA procedure may offer an advantage for isolating non-heat-stressed Listeria when the aerobic plate count of the product is high.
KW - biodeterioration
KW - diagnostic techniques
KW - isolation
KW - pathogens
KW - Seafoods
KW - Techniques
KW - Bacteria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911367491&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermal resistance of Listeria spp. in milk.
AU - Bradshaw, J. G.
AU - Peeler, J. T.
AU - Twedt, R. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 1
SP - 12
EP - 14
SN - 0362-028X
AD - Bradshaw, J. G.: Division of Microbiology, Food and Drug Administration, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19910444918. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The thermal resistance of 1 strain each of Listeria ivanovii, L. seeligeri and L. welshimeri and 3 L. monocytogenes strains was determined in raw and sterile milk. Listeria spp. suspended in milk at concn. of 1 × 105 cells/ml were heated at temp. ranging from 52.2 to 71.1°C for various contact times. The heat resistance of L. monocytogenes appeared greater than that of the other Listeria spp. in both milks, but the difference was not statistically significant (α = 0.05). HTST processing is adequate for pasteurization of raw milk.
KW - Cows
KW - heat resistance
KW - milk
KW - cattle
KW - Listeria
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Microbiology (General) (ZZ390)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910444918&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characteristics of vitamin and mineral supplement products in the United States.
AU - Park, Y. K.
AU - Kim, I.
AU - Yetley, E. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1991///
VL - 54
IS - 4
SP - 750
EP - 759
SN - 0002-9165
AD - Park, Y. K.: Food and Drug Administration, HFF-265, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19921442826. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - A 1986 nationwide survey of 11 775 adults 18 years or older and 1877 children 2 to 6 years old identified about 3400 different (unique) vitamin and mineral supplement products being taken. The most commonly included nutrient listed on the product levels was ascorbic acid which was present in 50% of the unique products examined. Calcium and iron were the most commonly included minerals and were present in 25% of the unique products examined. Prenatal and children's chewable products came in a relatively narrow potency range and generally contained nutrients in amounts approximating or less than the US recommended daily allowances. These products also contained significant minimum amounts of nutrients. Potencies of products not targeted for use by these special groups, particularly those products that were self-prescribed, varied widely and ranged from insignificant to extremely large amounts of nutrients. Units used to declare product potency or to prescribe the dosage varied.
KW - mineral supplements
KW - Vitamin supplements
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921442826&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence and growth potential of Bacillus cereus in ready-to-serve foods.
AU - Harmon, S. M.
AU - Kautter, D. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 5
SP - 372
EP - 374
SN - 0362-028X
AD - Harmon, S. M.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19910446645. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - To simulate temp. abuse, 106 test portions of ready-to-serve moist foods, 12 test portions of rehydrated dried infant formula, and 18 test portions of non-fat dried milk were incubated for 20 and 24 h at 26°C, and then examined for Bacillus cereus. Of the ready-to-serve moist foods, 88 of 106 were positive for B. cereus at levels ranging from 0.25 to 8.5 × 106/g after 20 h of incubation and from 0.1 to 58 × 106/g after 24 h. All of the dried milk and 12 of the 15 units of infant formula, representing 5 brands, were positive, with counts ranging from 0.15 to 5.0 × 106/g in 20 h and 5.0 to 49 × 106 after 24 h. B. cereus counts in the dried products were low, ranging from 0.09/g for 1 of 2 soya-based products to an av. of 0.29/g for milk-based products. However, these levels were sufficient to initiate growth of B. cereus in almost every 2-oz serving. Similar results were obtained for rehydrated non-fat milk, with initial B. cereus counts ranging from 0.29 to 1.5/g; at 26°C the counts averaged 3.3 × 107 after 20 h and 5.5 × 107 after 24 h. Counts ranged from 2.0 × 104 to 1.1 × 105 after 9 h in milk and were >106/g after 10.5 h.
KW - biodeterioration
KW - Cows
KW - determination
KW - dried milk
KW - infant formulae
KW - Prepared foods
KW - Bacillus cereus
KW - Bacteria
KW - cattle
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - infant formula
KW - infant formulas
KW - milk powder
KW - prepared dishes
KW - Milk and Dairy Produce (QQ010)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Science and Food Products (Human) (QQ000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910446645&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recovery of Salmonella from high-moisture foods by abbreviated selective enrichment.
AU - Allen, G.
AU - Bruce, V. R.
AU - Stephenson, P.
AU - Satchell, F. B.
AU - Andrews, W. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 7
SP - 492
EP - 495
SN - 0362-028X
AD - Allen, G.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19920450880. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - Five high-moisture foods were used to evaluate both the effect on a 6 h, rather than the standard 24 h, selective enrichment incubation period, and the efficiency of Rapport-Vassiliadis (RV) medium relative to the use of selenite cystine (SC) and tetrathionate (TT) broths for the recovery of Salmonella. Cheese and lettuce were artifically inoculated with a pool of 2 serotypes, whereas the other foods were naturally contaminated. Significantly higher numbers of Salmonella-positive test portions were obtained at 24 h with the following food and media combinations: cheese (TT and RV media), lettuce (SC, TT, and RV media), raw chicken (RV medium) and pork sausage (SC, TT, and RV media). There were no significant differences between the 2 incubation periods in recovery of Salmonella from turkey. Overall, more Salmonella-positive test portions were obtained from samples of lettuce, chicken and pork sausage selectively enriched in RV medium than in SC or TT broths. The results of this study indicate that not all high-moisture foods can be selectively enriched for 6 h without a significant loss in recovery of Salmonella. RV medium was superior to SC and TT broths for recovery of Salmonella from some meats, and was at least as productive in its recovery from the other high-moisture foods tested.
KW - biodeterioration
KW - cheeses
KW - Cows
KW - culture media
KW - Foods
KW - isolation
KW - Pathogens
KW - Techniques
KW - Bacteria
KW - cattle
KW - Salmonella
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920450880&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clostridium botulinum spores in corn syrup and other syrups.
AU - Lilly, T., Jr.
AU - Rhodehamel, J.
AU - Kautter, D. A.
AU - Solomon, H. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 8
SP - 585
EP - 587
SN - 0362-028X
AD - Lilly, T., Jr.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19920312215. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Sugar Industry
N2 - In a nationwide market survey across the USA, 738 sample bottles were collected: 354 light corn syrups, 271 dark corn syrups and 113 other syrups (pancake, waffle, maple and table syrups) with various corn syrup contents. A sample from each was diluted 1:1 with sterile distilled water containing 10% Tween 80, kept 30 min at 65°C, and vacuum-filtered through a sterile membrane filter having 0.45-µm pores; the filter was then incubated at 35° for 7 days on trypticase/peptone/glucose/yeast extract broth as nutrient for any C. botulinum spores present. Positive and negative controls were included in batches tested. Two syrups were presumptively positive for Type A spores: the first light syrup tested, and a dark syrup in the only batch where the negative control proved positive. Subsequent testing of the entire contents of these bottles proved negative. It is concluded that currently marketed corn syrups (and table syrups) pose negligible risk of botulism to infants.
KW - food microbiology
KW - Glucose syrups
KW - USA
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Sugar and Sugar Products (QQ020)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920312215&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of unacidified products bottled in oil for outgrowth and toxin production by Clostridium botulinum.
AU - Solomon, H. M.
AU - Kautter, D. A.
AU - Rhodehamel, E. J.
AU - Lilly, T., Jr.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1991///
VL - 54
IS - 8
SP - 648
EP - 649
SN - 0362-028X
AD - Solomon, H. M.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19921376385. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - A variety of unacidified products bottled in oil or water were investigated for their ability to support growth and toxin production by C. botulinum. The products were inoculated with a mixture of 5 strs of C. botulinum type A spores (~ 50 spores/g or ml) and incubated at room temp. (23°C). At monthly intervals the organoleptic acceptability of the products, as determined by appearance, odour and texture, was evaluated and a portion of each sample was removed, diluted 1:2 in gel-phosphate buffer and injected intraperitoneally into mice. At the end of 4 months the drained solids of each sample were macerated with a minimal amount of buffer and centrifuged; the clear extracts were then injected into mice. None of the products tested supported growth and toxin production by C. botulinum.
KW - biodeterioration
KW - bottling
KW - Food products
KW - Oils
KW - pathogens
KW - toxins
KW - Bacteria
KW - Clostridium botulinum
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - bacterium
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921376385&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epstein-barr virus transformation of Saimiri sciureus (Squirrel monkey) B cells and generation of a Plasmodium brasilianum-specific monoclonal antibody in P. brasilianum-infected monkeys.
AU - Chizzolini, C.
AU - Sulzer, A. J.
AU - Olsen-Rasmussen, M. A.
AU - Collins, W. E.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1991///
VL - 59
IS - 7
SP - 2285
EP - 2290
SN - 0019-9567
AD - Chizzolini, C.: W.E. Collins, Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910875319. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology
N2 - The susceptibility of S. sciureus B cells to Epstein-Barr virus (EBV) infection was tested. B-lymphoblastoid cell lines were obtained from 6 healthy animals after infection with the B95-8 source of EBV. The frequency distributions of spleen B cells clonally committed to the production of immunoglobulins M and G, as measured by limiting dilution analysis, were from 1 in 179 to 1 in 1085 and from 1 in 45 to 1 in 60, respectively, in 3 monkeys naturally infected with P. brasilianum. In the same animals, the frequency of spleen B cells committed to the production of P. brasilianum-specific antibody ranged from 1 in 2211 to 1 in 9099. One B-lymphoblastoid cell line producing anti-P. brasilianum-specific antibody was cloned twice, and the IgG produced was purified. This MAb recognized a parasite component of 197 000 MW and was specific for P. malariae and P. brasilianum parasites. These data document that squirrel monkey B cells naturally primed by an infectious agent can be efficiently used to produce monospecific antibodies against the infectious agent.
KW - Experimental infections
KW - immune response
KW - Laboratory animals
KW - monoclonal antibodies
KW - parasites
KW - Apicomplexa
KW - Cebidae
KW - Human herpesvirus 4
KW - Plasmodiidae
KW - Plasmodium brasilianum
KW - Primates
KW - protozoa
KW - Saimiri sciureus
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Lymphocryptovirus
KW - Gammaherpesvirinae
KW - viruses
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - Saimiri
KW - Cebidae
KW - Human herpesvirus 4
KW - Epstein-Barr virus
KW - immunity reactions
KW - immunological reactions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910875319&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A single amino acid change in the E2 glycoprotein of Venezuelan equine encephalitis virus affects replication and dissemination in Aedes aegypti mosquitoes.
AU - Woodward, T. M.
AU - Miller, B. R.
AU - Beaty, B. J.
AU - Trent, D. W.
AU - Roehrig, J. T.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1991///
VL - 72
IS - 10
SP - 2431
EP - 2435
SN - 0022-1317
AD - Woodward, T. M.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, USA.
N1 - Accession Number: 19920511694. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Four monoclonal antibody-resistant variants (MARVs) of Venezuelan equine encephalitis (VEE) virus were used to study mosquito-virus interactions. In vitro experiments using an A. albopictus cell line, C6/36, demonstrated that an amino acid change in the glycoprotein E2h epitope (MARV 1A3B-7) decreased virus growth when compared with the wild type, Trinidad donkey virus, and its vaccine derivative, TC-83. The MARVs replicated as efficiently as the parent virus when inoculated into A. aegypti mosquitoes, but MARV 1A3B-7 was restricted in its ability to infect and disseminate from the midgut following oral infection.
KW - Amino acids
KW - Cell lines
KW - Disease vectors
KW - Glycoproteins
KW - infections
KW - Replication
KW - Viral proteins
KW - Caribbean
KW - Puerto Rico
KW - Aedes aegypti
KW - Aedes albopictus
KW - Alphavirus
KW - Culicidae
KW - Diptera
KW - Togaviridae
KW - Venezuelan equine encephalitis virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - America
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Latin America
KW - Asian tiger mosquito
KW - mosquitoes
KW - Porto Rico
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - West Indies
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920511694&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food and Drug Administration pesticide residue monitoring of foods: 1978-1982.
AU - Yess, N. J.
AU - Houston, M. G.
AU - Gunderson, E. L.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1991///
VL - 74
IS - 2
SP - 265
EP - 272
AD - Yess, N. J.: Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19920454335. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Dairy Science; Medical & Veterinary Entomology; Agricultural Entomology; Human Nutrition; Horticultural Science; Postharvest Research
N2 - Results for 1978-82 were compiled from the 2 complementary elements that comprise the FDA programme for monitoring pesticide residues in foods. Under regulatory monitoring, which focuses on residues in raw agricultural commodities, a total of 49 877 samples (30 361 domestic and 19 516 imported) that included fresh fruits and vegetables, grains, milk and milk products, seafoods and a variety of processed foods were analysed. No residues were found in about 55 and 44% of domestic and import samples resp. About 3% of domestic and 7% of import samples were classed as violative. Data from the Total Diet Study, which is conducted to determine dietary intakes of a variety of chemicals, showed that residues of 42 pesticides were found in 1044 composites of table-ready foods. It is concluded that pesticide residue levels in the US food supply were generally well below regulatory limits in 1987-82 and dietary intakes were much lower than the Acceptable Daily Intakes established by international agencies.
KW - agricultural entomology
KW - assessment
KW - commodities
KW - Cows
KW - crops
KW - Foods
KW - Fruit crops
KW - Fruits
KW - Grain
KW - Insecticide residues
KW - insecticides
KW - Milk products
KW - monitoring
KW - Nontarget effects
KW - pesticide residues
KW - Pesticides
KW - residues
KW - Stored products
KW - Vegetables
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - surveillance systems
KW - United States of America
KW - vegetable crops
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Pesticides and Drugs (General) (HH400)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920454335&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of tolnaftate in commercial products.
AU - Thompson, R. D.
AU - Carlson, M.
JO - Journal - Association of Official Analytical Chemists
JF - Journal - Association of Official Analytical Chemists
Y1 - 1991///
VL - 74
IS - 4
SP - 603
EP - 607
AD - Thompson, R. D.: Food and Drug Administration, Minneapolis, MN 55401, USA.
N1 - Accession Number: 19911210425. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 2398-96-1. Subject Subsets: Medical & Veterinary Mycology
N2 - A liquid chromatographic method for the determination of tolnaftate is described. Isolation of the analyte was achieved by direct extraction or dilution with acetonitrile-water (80+20) followed by reverse-phase LC using a C18 column. The mobile phase was acetonitrile-water (80+20) acidified with phosphoric acid. Detection was by UV absorption at a wavelength of 257 nm. The proposed procedure was applied to 20 consumer products comprising 6 formulation types, including solutions, powders, liquid and powder aerosols, creams and gels. The precision (RSD) for the products ranged from 0.23 to 1.16% (n=5) and recoveries via fortification ranged from 96.8 to 103.8%. Six different brands of C18 columns were evaluated for use with the method. It is concluded that the overall simplicity and versatility of the method suggest possible adaptations to both regulatory and quality-control situations.
KW - Antifungal agents
KW - estimation
KW - liquid chromatography
KW - Tolnaftate
KW - fungistats
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911210425&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inoculation of ferrets with ten third-stage larvae of Dracunculus insignis.
AU - Brandt, F. H.
AU - Eberhard, M. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1991///
VL - 77
IS - 5
SP - 786
EP - 787
SN - 0022-3395
AD - Brandt, F. H.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920876333. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Helminthology
N2 - Infection with D. insignis was established in 7 of 10 ferrets experimentally inoculated intraperitoneally with ten 3rd-stage larvae (L3's). Worm recovery and infection rate were comparable to animals inoculated with 50 L3's. This study demonstrates that once infective larvae traverse the gut and pass into the peritoneal cavity, very few larvae are required to establish infection.
KW - Disease models
KW - experimental infection
KW - Experimental infections
KW - helminths
KW - Laboratory animals
KW - parasites
KW - Carnivores
KW - Dracunculidae
KW - Dracunculus insignis
KW - ferrets
KW - Mustelidae
KW - Nematoda
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Dracunculus
KW - Dracunculidae
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - experimental transmission
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876333&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A Brugia species infecting rabbits in the Northeastern United States.
AU - Eberhard, M. L.
AU - Telford, S. R., III
AU - Spielman, A.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1991///
VL - 77
IS - 5
SP - 796
EP - 798
SN - 0022-3395
AD - Eberhard, M. L.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920876337. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Veterinary Science; Helminthology
N2 - Brugia sp. microfilariae were observed in more than 60% of wild rabbits collected on Nantucket Island, Massachusetts, USA. The microfilariae measured 294-344 µm in length and had the characteristic subterminal and terminal nuclei observed in other Brugia microfilariae. The microfilaria is similar to those previously described for Brugia leporis in rabbits in Louisiana, USA. This may be the Brugia species responsible for 21 documented cases of human infection in the northeastern United States.
KW - Developmental stages
KW - Filariasis
KW - Filariids
KW - helminths
KW - Microfilariae
KW - parasites
KW - rabbit diseases
KW - Wild animals
KW - Zoonoses
KW - Massachusetts
KW - North America
KW - USA
KW - Brugia
KW - Lagomorpha
KW - Leporidae
KW - Nematoda
KW - Onchocercidae
KW - rabbits
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mammals
KW - vertebrates
KW - Chordata
KW - Lagomorpha
KW - Leporidae
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - growth phase
KW - nematodes
KW - parasitic worms
KW - Prevalence
KW - Secernentea
KW - Spirurida
KW - United States of America
KW - zoonotic infections
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920876337&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A multistate outbreak of hepatitis A caused by the consumption of raw oysters.
AU - Desenclos, J. C. A.
AU - Klontz, K. C.
AU - Wilder, M. H.
AU - Nainan, O. V.
AU - Margolis, H. S.
AU - Gunn, R. A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991///
VL - 81
IS - 10
SP - 1268
EP - 1272
SN - 0090-0036
AD - Desenclos, J. C. A.: Hepatitis Branch, Centers for Disease Control, Public Health Service, Atlanta, GA, USA.
N1 - Accession Number: 19931465880. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Public Health
N2 - A case report of an outbreak of hepatitis A in 61 patients in 5 US states due to the consumption of raw oysters harvested in the coastal waters of Panama City, Florida, USA is presented.
KW - Case reports
KW - Food
KW - Food poisoning
KW - foodborne diseases
KW - Hepatitis
KW - Hepatitis A
KW - Intake
KW - Oysters
KW - raw foods
KW - shellfish
KW - USA
KW - Man
KW - viruses
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - America (North)
KW - raw oysters
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465880&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total diet study nutritional elements, 1982-1989.
AU - Pennington, J. A. T.
AU - Young, B. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1991///
VL - 91
IS - 2
SP - 179
EP - 183
SN - 0002-8223
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19911435939. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - Daily intakes of 11 nutritional elements for 8 age-sex groups are presented. Compared with the intakes recommended by the National Academy of Sciences, sodium intakes (excluding discretionary salt) exceeded the estimated minimum requirement; intakes of potassium, phosphorus, selenium, and iodine were adequate for all groups; calcium, magnesium, iron, and manganese were low in diets of adolescent girls; Ca, Mg, and Fe were low in the diets of adult women; Ca, Mg, and Zn were low in the diets of older women; Ca, and Zn were low in the diets of 2-year-olds; and Mg was low in the diets of adolescent boys and older men. Primary food group sources were dairy products for K, Ca, P, Mg, and I; grain products for Na, Fe, and Mn; and animal flesh for Zn, Se, and Cu.
KW - Diet studies
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911435939&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Priority-based assessment of food additives database of the U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition.
AU - Benz, R. D.
AU - Irausquin, H.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 1991///
VL - 96
SP - 85
EP - 89
SN - 0091-6765
AD - Benz, R. D.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Toxicological Review and Evaluation, HFF-156, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19931456063. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition
N2 - The priority-based assessment of food additives (PAFA) is a database maintained by the US Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition. PAFA contains extensive administrative, chemical and toxicological information on 1685 regulated direct food additives. The database also has limited administrative and chemical information on an additional 1236 direct additives. The total 2921 substances represent everything added to food in the USA. PAFA contains up to 150 different kinds of information abut each chemical. Administrative and chemical information includes Chemical Abstracts Service Registry numbers, Code of Federal Regulations citations, the annual usage and estimated daily US human consumption, the Joint Committee on Food Additives Allowable Daily Intakes, the FDA Redbook structure categories of the chemicals and their technical effects. Toxicology information shows the type of studies done for each chemical, the species of animals tested, the toxicological effects observed and the sites where they were seen, the lowest doses that cause a toxicological effect in each study, a source citation and other types of related information.
KW - Databases
KW - food additives
KW - food safety
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - data banks
KW - United States of America
KW - Information and Documentation (CC300)
KW - Food Additives (QQ130)
KW - Human Nutrition (General) (VV100)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456063&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fumigants and related chemicals in foods: review of residue findings, contamination sources, and analytical methods.
AU - Daft, J. L.
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 1991///
VL - 100
SP - 501
EP - 518
SN - 0048-9697
AD - Daft, J. L.: US Department of Health and Human Service, Food and Drug Administration, Kansas City, MO 64106, USA.
N1 - Accession Number: 19950506108. Publication Type: Journal Article. Language: English. Number of References: 6 pp. of ref. Registry Number: 56-23-5, 67-66-3, 106-93-4, 74-83-9, 7803-51-2.
N2 - Public concern over chemical residues in foods increased in the US during the early 1980s. Potentially hazardous levels of ethylene dibromide (EDB), a relatively non-volatile fumigant, were detected in several finished grain-based products by governmental food-monitoring laboratories. As a result, the US Environmental Protection Agency banned the use of EDB as a fumigant in 1983. Commercial fumigators then began using more of the highly volatile chemicals such as methyl bromide and phosphine. These chemicals are less likely to leave residues on stored crops than the previously used fumigants such as EDB, chloroform and carbon tetrachloride. However, trace residues of many pest-control fumigants and related industrial chemicals are currently found in assorted foods. This contamination may come from the original fumigation of stored crops, or from the industrial chemicals occurring in the environment and in food processing chains. No potential health problem has been identified now, yet scientists continue to uncover the sources of this chemical contamination and to develop better methods to monitor foods for it. They also seek better ways to protect foodstuffs from pests prior to human consumption.
KW - analytical methods
KW - carbon tetrachloride
KW - chloroform
KW - ethylene dibromide
KW - foods
KW - fumigants
KW - insecticide residues
KW - methyl bromide
KW - pesticide residues
KW - phosphine
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - 1,2-dibromoethane
KW - analytical techniques
KW - bromomethane
KW - EDB
KW - tetrachloromethane
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506108&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Canthaxanthin and excess vitamin A alter α-tocopherol, carotenoid and iron status in adult rats.
AU - Blakely, S. R.
AU - Mitchell, G. V.
AU - Jenkins, M. Y.
AU - Grundel, E.
AU - Whittaker, P.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1991///
VL - 121
IS - 10
SP - 1649
EP - 1655
SN - 0022-3166
AD - Blakely, S. R.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19921441263. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 59-02-9, 514-78-3, 7439-89-6. Subject Subsets: Human Nutrition
N2 - Plasma α-tocopherol in young rats is decreased when they are given β-carotene and excess vitamin A. Male rats 8 to 10 months old were given different amounts of retinyl palmitate, β-carotene and canthaxanthin for 8 weeks. The AIN-76A diet was modified to contain 16% fat and 50% carbohydrate (control) without or with β-carotene (BC) or canthaxanthin (CX) 0.048 or 0.2%. These compounds were given without or with excess retinyl palmitate (RP) 220 mg/kg. Groups given CX and RP had greater relative liver weight. Plasma retinyl esters were detected in all groups given RP. Plasma retinyl palmitate was 1.6- and 1.5-fold higher in RP-BC and RP-CX groups, respectively, than in RP groups. Plasma and liver BC and CX were 11 to 54% and 26 to 74% lower, respectively, with excess RP. When CX and RP were given, but not BC, α-tocopherol in plasma was decreased. Liver non-haem iron was lower in rats given CX irrespective of RP feeding.
KW - alpha-Tocopherol
KW - canthaxanthin
KW - Carotenoids
KW - Iron
KW - vitamin A excess
KW - hypervitaminosis A
KW - tetraterpenoids
KW - vitamin A toxicity
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921441263&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety of ethoxyquin in dog foods.
AU - Dzanis, D. A.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1991///
VL - 121
IS - 11S
SP - S163
EP - S164
SN - 0022-3166
AD - Dzanis, D. A.: Animal Feed Safety Branch, Center for Veterinary Medicine, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19921443151. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 ref. Registry Number: 91-53-2. Subject Subsets: Animal Nutrition
N2 - Available information on the safety of ethoxyquin in dog foods is reviewed. It is concluded that there is insufficient scientific evidence to show that ethoxyquin is unsafe when used at approved amounts or to warrant action against its use in pet foods.
KW - dog foods
KW - Ethoxyquin
KW - reviews
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - santoquin
KW - United States of America
KW - Waltham International Symposium on the Nutrition of Small Companion Animals
KW - Pesticides and Drugs (General) (HH400)
KW - Feed Additives (RR130)
KW - Feed Composition and Quality (RR300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921443151&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Synthetic peptides of Venezuelan equine encephalomyelitis virus E2 glycoprotein. III. Identification of a prospective peptide derived from the carboxy-terminal extramembranal one-third of the protein.
AU - Johnson, A. J.
AU - Hunt, A. R.
AU - Roehrig, J. T.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1991///
VL - 185
IS - 2
SP - 840
EP - 842
SN - 0042-6822
AD - Johnson, A. J.: Division of Vector-Borne Infectious Diseases, Center for Infectious Diseases Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19932290023. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - Six synthetic peptides corresponding to the extramembranal carboxy-terminal one-third of the E2 glycoprotein of Venezuelan equine encephalomyelitis (VEE) virus were used to immunize NIH-Swiss mice with 2 s.c. injections of 50 µg given 14 days apart, the first emulsified 1:1 in Freund's incomplete adjuvant, the second in Freund's complete adjuvant; antipeptide and antiviral titres were measured by ELISA. Peptide 13 (amino acids 241-265) protected 60-70% of virus-challenged mice. The other peptides elicited antipeptide ELISA titres but low or no antiviral titres and did not protect mice even though E2 reactivity was found in immunoblots. These results indicate that much of the E2 carboxy-terminal domain is cryptic in the VEE virion, even when the virus was bound to polystyrene ELISA plates.
KW - arboviruses
KW - ELISA
KW - glycoproteins
KW - immunization
KW - Immunoblotting
KW - Peptides
KW - viral diseases
KW - Viral proteins
KW - Alphavirus
KW - Equine encephalomyelitis virus
KW - mice
KW - Venezuelan equine encephalitis virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Alphavirus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - equine encephalomyelitis virus
KW - arthropod-borne viruses
KW - enzyme linked immunosorbent assay
KW - immune sensitization
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - viral infections
KW - Techniques and Methodology (ZZ900)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932290023&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of veterinarians' recommendations for treatment and control of intestinal parasites in dogs: public health implications.
AU - Harvey, J. B.
AU - Roberts, J. M.
AU - Schantz, P. M.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1991///
VL - 199
IS - 6
SP - 702
EP - 707
SN - 0003-1488
AD - Harvey, J. B.: Parasitic Diseases Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Dept. of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19922262597. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Veterinary Science; Veterinary Science; Helminthology
N2 - Results are given from a telephone survey of 450 small and mixed-animal practitioners to assess whether current veterinary practices concerning prophylaxis and treatment of canine roundworm (Toxocara canis) and hookworm (Ancylostoma spp.) infections are adequate to prevent transmission to human beings. Only a third (148/450) of veterinarian respondents routinely discussed the potential zoonotic hazards of canine roundworms with their clients. A total of 29% (130/450) either never discussed these potential hazards or discussed them only when asked by their clients. With regard to anthelmintic treatment practices, 31% (140/450) of veterinarians surveyed recommended that pups first be examined and treated for intestinal parasites within 4 weeks of age. 33% (163/450) recommended first examination and deworming at 5 to 6 weeks of age, and 36% (163/450) suggested that it be done at or after 7 weeks of age. Less than half (208/450) of veterinarians administered anthelmintics prophylactically to at least some pups and dogs. 64% (287/450) of respondents recommended routine testing and treatment of nursing bitches. It was concluded that current veterinary practices are inadequate for maximum prevention of environmental contamination with eggs of these intestinal helminths. It is recommended that prophylactic deworming programmes be initiated 2 to 3 weeks after pups are whelped, and that these programmes include the nursing bitch. Treatment should be repeated every 2 to 3 weeks until 3 months after birth. Dog breeders and pet store owners, as well as private pet owners, need to be educated regarding the time to begin deworming the pups and bitch to effectively reduce environmental contamination with eggs of roundworms and hookworms.
KW - Anthelmintics
KW - control
KW - Disease control
KW - Disease prevention
KW - dog diseases
KW - Domestic animals
KW - helminths
KW - Human diseases
KW - parasites
KW - Parasitoses
KW - prevention
KW - Public health
KW - Small animal practice
KW - Zoonoses
KW - USA
KW - Ancylostoma
KW - Ancylostomatidae
KW - Ascarididae
KW - Canidae
KW - Carnivores
KW - dogs
KW - Nematoda
KW - Toxocara
KW - Toxocara canis
KW - Ancylostomatidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - Canis
KW - Canidae
KW - Ascarididae
KW - Toxocara
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Ascaridida
KW - nematodes
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - Secernentea
KW - Strongylida
KW - United States of America
KW - zoonotic infections
KW - Animal Health and Hygiene (General) (LL800)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pets and Companion Animals (LL070)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922262597&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid clean-up of fat extracts for organophosphorus pesticide residue determination using C18 solid-phase extraction cartridges.
AU - Gillespie, A. M.
AU - Walters, S. M.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 1991///
VL - 245
IS - 2
SP - 259
EP - 265
SN - 0003-2670
AD - Gillespie, A. M.: Pesticides and Industrial Chemicals Research Center, Food and Drug Administration, 1560 E. Jefferson Avenue., Detroit, MI 48207 USA.
N1 - Accession Number: 19911437073. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 8001-23-8, 8001-22-7. Subject Subsets: Human Nutrition; Soyabeans; Maize; Dairy Science
N2 - A method is described for the determination of organo-phosphorus pesticide residues in fats and oils. Recoveries of 7 compounds at 0.05-0.87 µg/g from sunflower, maize, safflower, soyabean and olive oils, and milk fat ranged from 80 to 103%. Practical limits of determination range from 0.01 to 0.08 µg/g depending on analyte response.
KW - analytical methods
KW - Cows
KW - determination
KW - maize
KW - Maize oil
KW - milk fat
KW - Organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - plant oils
KW - residues
KW - Safflower oil
KW - Soyabean oil
KW - techniques
KW - cattle
KW - Zea mays
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - analytical techniques
KW - butterfat
KW - corn
KW - corn oil
KW - soybean oil
KW - vegetable oils
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19911437073&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety of bovine growth hormone: response.
AU - Juskevich, J. C.
AU - Guyer, C. G.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1991///
VL - 251
IS - 4491
SP - 256
EP - 257
SN - 0036-8075
AD - Juskevich, J. C.: Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19920450694. Publication Type: Journal Article. Language: English. Registry Number: 9002-72-6. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - This is a response to the letter of the preceding abst.
KW - Cows
KW - milk
KW - public health
KW - safety
KW - Somatotropin
KW - cattle
KW - MAN
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - growth hormone
KW - Health Services (UU350)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920450694&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Circumsporozoite protein gene from Plasmodium reichenowi, a chimpanzee malaria parasite evolutionarily related to the human malaria parasite Plasmodium falciparum.
AU - Lal, A. A.
AU - Goldman, I. F.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1991///
VL - 266
IS - 11
SP - 6686
EP - 6689
SN - 0021-9258
AD - Lal, A. A.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19910881916. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - A gene encoding the circumsporozoite (CS) protein of P. reichenowi, a P. falciparum-like malaria parasite of chimpanzees, was cloned and sequenced. Comparison of the 2 CS proteins revealed both similarities and differences in these 2 evolutionarily related parasites that have adapted to different hosts. The P. reichenowi CS protein has a new repeat sequence, NVNP, in addition to the P. falciparum-like NANP and NVDP repeats. In the immunodominant TH2R and TH3R regions of the CS protein, the amino acid sequences are similar in both parasite proteins. The differences in the 2 proteins exist in domains around the conserved regions, Region I and Region II, which are otherwise conserved in the CS proteins of P. falciparum analysed to date.
KW - biotechnology
KW - circumsporozoite protein
KW - genes
KW - human diseases
KW - malaria
KW - molecular biology
KW - parasites
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodium falciparum
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - circumsporozoite protein gene
KW - Plasmodium reichenowi
KW - relationship P. falciparum
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910881916&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anti-nutritive effects of dietary tin.
AU - Rader, J. I.
A2 - Friedman, M.
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
Y1 - 1991///
VL - 289
SP - 509
EP - 524
AD - Rader, J. I.: Division of Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19931457580. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 51 ref. Registry Number: 7440-31-5. Subject Subsets: Human Nutrition
N2 - Tin is usually present in foods at levels of less than 4 µg/g. Higher levels may be found in some processed foods due to the addition of tin-based preservatives and stabilizers or to corrosion and leaching of the metal from unlacquered cans or from tin foils used in packaging. Estimates of dietary intake range from about 0.2 to >5 mg Sn/day. Diets including a high proportion of canned vegetables and fish could supply >30 mg Sn/day. Although intakes from dietary sources are generally considered to be harmless, a variety of adverse effects of tin have been reported, including effects on serum and bone alkaline phosphatase, lactic dehydrogenase, haeme oxygenase and 5-aminolevulinic acid dehydratase. Perturbations in glutathione metabolism have been reported, as have adverse effects on metabolism of essential trace minerals such as copper, zinc and iron. Specific effects on calcium content of bone, serum and kidney have also been described. Effects of tin in animal systems and on essential trace mineral absorption and excretion in man are reviewed. A summary of recent investigations on dietary tin-copper interactions and effects of tin on rat hepatocellular antioxidant protection are also presented.
KW - Foods
KW - reviews
KW - Tin
KW - toxicity
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Nutritional and toxicological consequences of food processing
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931457580&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternal filarial infection as risk factor for infection in children.
AU - Lammie, P. J.
AU - Hitch, W. L.
AU - Allan, E. M. W.
AU - Hightower, W.
AU - Eberhard, M. L.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1991///
VL - 337
IS - 8748
SP - 1005
EP - 1006
SN - 0140-6736
AD - Lammie, P. J.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920880176. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Helminthology
N2 - Familial clustering of filarial infection was investigated through random house-to-house surveys of 643 individuals in Leogane, Haiti, an area with endemic bancroftian filariasis. Children of infected mothers were 2.4 to 2.9 times more likely to be infected than were those of amicrofilaraemic mothers. Filarial-specific cellular responsiveness in amicrofilaraemic children born to infected mothers was lower than that in amicrofilaraemic children born to amicrofilaraemic mothers. No effect of paternal infection status was seen. The findings of this study show that maternal infection is a risk factor for filarial infection in children and is associated with altered parasite-specific immune reactivity.
KW - children
KW - epidemiology
KW - familial incidence
KW - helminths
KW - human diseases
KW - parasites
KW - Caribbean
KW - Haiti
KW - man
KW - nematoda
KW - onchocercidae
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Wuchereria
KW - Onchocercidae
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920880176&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide residue method development and validation at the Food and Drug Administration.
AU - Clower, M., Jr.
JO - ACS Symposium Series
JF - ACS Symposium Series
Y1 - 1991///
IS - 446
SP - 105
EP - 113
SN - 0841219060
AD - Clower, M., Jr.: Pesticide and Industrial Chemicals Branch, Division of Contaminants Chemistry, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street SW, WA 20204, USA.
N1 - Accession Number: 19922319221. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref. Subject Subsets: Weeds; Agricultural Entomology; Plant Pathology; Postharvest Research
N2 - The development and validation of analytical methods for pesticide residue detection currently being carried out by the U.S. Food and Drug Administration are outlined.
KW - agricultural entomology
KW - analysis
KW - analytical methods
KW - detection
KW - determination
KW - Herbicides
KW - Insecticide residues
KW - insecticides
KW - Nontarget effects
KW - pesticide residues
KW - Pesticides
KW - plant pathology
KW - residues
KW - Techniques
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American Chemical Society
KW - analytical techniques
KW - Pesticide residues and food safety
KW - phytopathology
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922319221&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The food and drug administration program on pesticide residues in food.
AU - Lombardo, P.
AU - Yess, N. J.
JO - ACS Symposium Series
JF - ACS Symposium Series
Y1 - 1991///
IS - 446
SP - 162
EP - 169
SN - 0841219060
AD - Lombardo, P.: Division of Contaminants Chemistry, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington DC, WA 20204, USA.
N1 - Accession Number: 19922318901. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 25 ref. Subject Subsets: Weeds; Human Nutrition; Agricultural Entomology; Plant Pathology; Postharvest Research
N2 - Some recent results are discussed from the USA Food and Drug Administration's (FDA) programme for monitoring pesticide residues in food. In 1988, no residues were found in 61% of more than 18 000 samples analysed and findings from the Total Diet Study corroborate results from previous years about low levels of pesticide residues present in foods as consumed. Important recent FDA initiatives are concerned with improving residue analytical capability, intelligence in pesticide usage and sampling approaches. Since there is some public perception that pesticide residues in foods constitute a significant health risk, attention also needs to be directed toward this issue.
KW - agricultural entomology
KW - food
KW - foods
KW - Herbicides
KW - Insecticide residues
KW - Insecticides
KW - monitoring
KW - Nontarget effects
KW - pesticide residues
KW - pesticides
KW - plant pathology
KW - residues
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American Chemical Society
KW - Pesticide residues and food safety
KW - phytopathology
KW - surveillance systems
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922318901&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide residues in food. U.S. Food and Drug Administration's Program for immunoassay.
AU - Clower, M.
JO - ACS Symposium Series
JF - ACS Symposium Series
Y1 - 1991///
IS - 451
SP - 49
EP - 58
SN - 0841219052
AD - Clower, M.: Pesticide and Industrial Chemicals Branch, Division of Contaminants Chemistry, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street S.W., Washington DC 20204, USA.
N1 - Accession Number: 19912314136. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Registry Number: 17804-35-2, 10605-21-7, 22224-92-6, 38641-94-0, 1071-83-6, 70393-85-0, 2074-50-2, 4685-14-7, 1910-42-5, 23564-05-8. Subject Subsets: Weeds; Human Nutrition; Plant Pathology; Soyabeans; Postharvest Research; Agricultural Entomology; Agricultural Biotechnology
N2 - The use of immunoassays as a means of testing for pesticide residues in foods are currently being assessed by the U.S. Food and Drug Administration (FDA). The potential benefits and considerations for the development of immunoassays for regulatory analyses, potential applications of enzyme immunoassay (EIA) methods in residue monitoring and FDA research on commercial immunoassay kits and EIA method development are discussed. Specific immunoassay methods that are being developed for the detection of paraquat in potatoes, fenamiphos and its sulfoxide and sulfone metabolites in oranges, carbendazim, benomyl and thiophanate-methyl in apples and glyphosate in soyabeans are also described.
KW - agricultural entomology
KW - analytical methods
KW - Apples
KW - benomyl
KW - biotechnology
KW - carbendazim
KW - determination
KW - fenamiphos
KW - food
KW - foods
KW - fungicide residues
KW - Glyphosate
KW - herbicide residues
KW - Herbicides
KW - immunoassay
KW - Immunological techniques
KW - Insecticide residues
KW - Insecticides
KW - nematicide residues
KW - Nontarget effects
KW - Oranges
KW - Paraquat
KW - pesticide residues
KW - Pesticides
KW - plant pathology
KW - potatoes
KW - residues
KW - soyabeans
KW - Techniques
KW - thiophanate-methyl
KW - USA
KW - Citrus
KW - Citrus sinensis
KW - Glycine (Fabaceae)
KW - Glycine max
KW - Malus
KW - Malus pumila
KW - Solanum tuberosum
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Citrus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Glycine (Fabaceae)
KW - Rosaceae
KW - Rosales
KW - Malus
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - carbendazol
KW - fenamiphos carbendazim
KW - fundazol
KW - International Chemical Congress of Pacific Basin Societies
KW - MBC
KW - medamine
KW - methyl thiophanate
KW - phenamiphos
KW - phytopathology
KW - Rutales
KW - serological techniques
KW - soybeans
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19912314136&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Design options considerations for retrofit ROPS.
AU - Etherton, J. R.
AU - Hause, M. G.
AU - Hsiao, H.
AU - Bobick, T. G.
T2 - Paper - American Society of Agricultural Engineers
JO - Paper - American Society of Agricultural Engineers
JF - Paper - American Society of Agricultural Engineers
Y1 - 1991///
IS - 91-5501
SP - 11
EP - 11
SN - 0149-9890
AD - Etherton, J. R.: National Institute for Occupational Safety and Health, Division of Safety Research, 944 Chestnut Ridge Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19922454800. Publication Type: Miscellaneous. Language: English. Number of References: 12 ref. Subject Subsets: Agricultural Engineering
N2 - Observations and biomechanical analyses of lifting tasks that could be used in deploying two different types of manually adjustable Rollover Protection Structures (ROPS) for older farm tractors are summarized. Lifts associated with a folding and a telescoping type ROPS were analyzed using a program developed by the University of Michigan for predicting the musculoskeletal loading of various body links. The lifting software's calculation method requires the following data: (1) the body link angles, (2) the number of hands used, (3) the load magnitude of the lift, and (4) the direction of the lift. An initial hypothesis was that compression forces in the lower back would impose the most important limiting factor on how people would use adjustable ROPS on older farm tractors. However, this analysis indicates that shoulder strength capability could be an important predictor of musculoskeletal loading that designers of this type of safety device should consider. Further ergonomic consideration of adjustable ROPS for older farm tractors is warranted.
KW - adjustment
KW - computer analysis
KW - ergonomics
KW - Roll over protection structures
KW - tractors
KW - antiroll structures
KW - human engineering
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Automation and Control (NN050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19922454800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Natural occurrence of mycotoxins.
AU - Pohland, A. E.
AU - Wood, G. E.
A2 - Bray, G. A.
A2 - Ryan, D. H.
T2 - Mycotoxins, cancer, and health.
JO - Mycotoxins, cancer, and health.
JF - Mycotoxins, cancer, and health.
Y1 - 1991///
SP - 32
EP - 52
CY - Baton Rouge; USA
PB - Louisiana State University Press
SN - 0807116793
AD - Pohland, A. E.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19931251149. Publication Type: Miscellaneous. Language: English. Number of References: 23 ref. Registry Number: 10048-13-2, 641-38-3, 25425-12-1, 518-75-2, 18172-33-3, 23282-20-4, 149-29-1, 90-65-3, 21259-20-1, 27778-66-1, 610-88-8, 75652-74-3, 51481-10-8, 17924-92-4, 31876-38-7. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology
N2 - The natural occurrence of mycotoxins and problems with their detection in foods are discussed. The incidence and levels of mycotoxins in the USA, as measured by Food and Drug Administration surveys, are presented. Contamination of food by aflatoxins, alternariol, alternariol methyl ether, tenuazonic acid, ochratoxin A, sterigmatocystin, deoxynivalenol [vomitoxin], zearalenone, fumonisin B1, moniliformin, nivalenol, T-2 toxin, patulin, citrinin, citreoviridin, cyclopiazonic acid, penicillic acid, penitrem A and roquefortine is reported.
KW - Aflatoxins
KW - Alternariol
KW - biodeterioration
KW - Citreoviridin
KW - Citrinin
KW - contamination
KW - Cyclopiazonic acid
KW - foods
KW - Fumonisins
KW - Moniliformin
KW - mycotoxins
KW - Nivalenol
KW - occurrence
KW - Ochratoxins
KW - Patulin
KW - Penicillic acid
KW - Penitrems
KW - Sterigmatocystin
KW - T-2 toxin
KW - Tenuazonic acid
KW - Vomitoxin
KW - Zearalenone
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Alternariol methyl ether
KW - deoxynivalenol
KW - f-2 toxin
KW - fungal toxins
KW - fusariotoxin
KW - Roquefortines
KW - United States of America
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251149&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Isolation of parasites on fruits and vegetables.
AU - Bier, J. W.
A2 - Cross, J. H.
T2 - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar, Chiang Mai, Thailand, 14-17 November 1990.
JO - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar, Chiang Mai, Thailand, 14-17 November 1990.
JF - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar, Chiang Mai, Thailand, 14-17 November 1990.
Y1 - 1991///
SP - 144
EP - 145
CY - Bangkok; Thailand
PB - SEAMEO Regional Tropical Medicine & Public Health Project
AD - Bier, J. W.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19940805709. Publication Type: Conference paper. Language: English. Number of References: 1 ref. Subject Subsets: Helminthology; Protozoology
KW - helminths
KW - isolation techniques
KW - microbiology
KW - parasites
KW - protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805709&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Aflatoxin M1.
AU - Wood, G. E.
A2 - Sharma, R. P.
A2 - Salunkhe, D. K.
T2 - Mycotoxins and phytoalexins.
JO - Mycotoxins and phytoalexins.
JF - Mycotoxins and phytoalexins.
Y1 - 1991///
SP - 145
EP - 164
CY - Boca Raton, Florida; USA
PB - CRC Press, Inc.
SN - 0849388333
AD - Wood, G. E.: Division of Contaminants Chemistry, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19921211793. Publication Type: Miscellaneous. Language: English. Number of References: 109 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Postharvest Research; Dairy Science
N2 - An overview of aflatoxin M1 (AFM1), including chemistry, metabolism and toxicological considerations, analytical methods, occurrence, AFM1 in milk products, and regulation and control of AFM1, is presented.
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - Cows
KW - milk
KW - milk products
KW - Mycotoxins
KW - reviews
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin M1
KW - dairy products
KW - fungal toxins
KW - Milk and Dairy Produce (QQ010)
KW - Biodeterioration (SS300)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921211793&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Recent studies on the neoplasia and abnormal cellular differentiation in methyl insufficiency.
AU - Poirier, L. A.
A2 - Jacobs, M. M.
T2 - Vitamins and minerals in the prevention and treatment of cancer.
JO - Vitamins and minerals in the prevention and treatment of cancer.
JF - Vitamins and minerals in the prevention and treatment of cancer.
Y1 - 1991///
SP - 161
EP - 172
CY - Boca Raton; USA
PB - CRC Press
SN - 0849342597
AD - Poirier, L. A.: National Center for Toxicological Research, HFT-140, Division of Comparative Toxicology, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19921447170. Publication Type: Miscellaneous. Language: English. Number of References: 57 ref. Registry Number: 62-49-7, 68-19-9, 59-30-3, 63-68-3. Subject Subsets: Human Nutrition
N2 - The relation of methyl deficiency to neoplasia and the paradox that, in light of the carcinogenic and co-carcinogenic activities of dietary methyl deprivation towards the liver, when adequately investigated, dietary deficiencies of vitamin B12 and folic acid have tended to inhibit liver carcinogenesis, are reviewed. De novo synthesis of methyl groups and associated disorders and their relation to neoplasia are discussed.
KW - Carcinoma
KW - Cell differentiation
KW - choline
KW - cyanocobalamin
KW - folic acid
KW - methionine
KW - nutrient deficiencies
KW - vitamin B12
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cobalamin
KW - cytodifferentiation
KW - disorders
KW - folacin
KW - folate
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921447170&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Testing for food-borne parasites, their metabolic products and symbionts.
AU - Jackson, G. J.
A2 - Cross, J. H.
T2 - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
JO - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
JF - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
Y1 - 1991///
SP - 334
EP - 336
CY - Bangkok; Thailand
PB - SEAMEO Regional Tropical Medicine & Public Health Project
AD - Jackson, G. J.: Division of Microbiology, United States Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19940806088. Publication Type: Conference paper. Language: English. Number of References: 7 ref. Subject Subsets: Helminthology
KW - foodborne diseases
KW - helminths
KW - isolation
KW - parasites
KW - techniques
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - nematodes
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940806088&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Principles and costs in the regulation of microbially contaminated foods.
AU - Jackson, G. J.
A2 - Cross, J. H.
T2 - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
JO - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
JF - Emerging problems in food-borne parasitic zoonosis: impact on agriculture and public health. Proceedings of the 33rd SEAMEO-TROPMED Regional Seminar Chiang Mai, Thailand, 14-17 November 1990.
Y1 - 1991///
SP - 382
EP - 383
CY - Bangkok; Thailand
PB - SEAMEO Regional Tropical Medicine & Public Health Project
AD - Jackson, G. J.: Division of Microbiology, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19940806188. Publication Type: Conference paper. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Helminthology; Protozoology
KW - food contamination
KW - foodborne diseases
KW - helminths
KW - human diseases
KW - microbial contamination
KW - parasites
KW - regulations
KW - USA
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - parasitic worms
KW - rules
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940806188&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Identification of microorganisms in dairy products by using gene probes.
AU - Hill, W. E.
T2 - Proceedings of the XXIII International Dairy Congress, Montreal, October 8-12, 1990, Vol. 2.
JO - Proceedings of the XXIII International Dairy Congress, Montreal, October 8-12, 1990, Vol. 2.
JF - Proceedings of the XXIII International Dairy Congress, Montreal, October 8-12, 1990, Vol. 2.
Y1 - 1991///
SP - 1337
EP - 1344
CY - Brussels; Belgium
PB - International Dairy Federation
SN - 0969471300
AD - Hill, W. E.: Division of Microbiology, U.S. Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19910448750. Publication Type: Conference paper. Language: English. Number of References: 22 ref. Registry Number: 9007-49-2. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science; Agricultural Biotechnology
N2 - Methods based on DNA hybridization with gene probes can determine the presence of particular bacterial genera or strains in foods amidst a high background of indigenous microflora. These sensitive tests may improve the ability to identify the agents of foodborne microbial disease above the present confirmation rate of about 40%. Gene probes have been developed to identify Salmonella, Campylobacter and Listeria species, and haemolytic Listeria monocytogenes, enterotoxigenic Escherichia coli and virulent Yersinia enterocolitica. These pathogenic bacteria are occasionally found in milk products. Gene amplification techniques, such as the polymerase chain reaction, may greatly increase the sensitivity of these methods and reduced the time required to conduct them.
KW - Biotechnology
KW - Cows
KW - DNA
KW - DNA probes
KW - foods
KW - identification
KW - milk products
KW - Nucleic acids
KW - Bacteria
KW - cattle
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - dairy products
KW - deoxyribonucleic acid
KW - International Dairy Congress
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19910448750&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Ecology and management of food-industry pests.
A2 - Gorham, J. R.
T2 - Ecology and management of food-industry pests.
Y1 - 1991///
CY - Arlington, Virginia; USA
PB - Association of Official Analytical Chemists
SN - 0935584455
AD - Food and Drug Administration, Public Health Service, US Department of Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19921159189. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition; Agricultural Entomology; Postharvest Research; Medical & Veterinary Entomology
N2 - This volume, entitled 'Ecology and management of food-industry pests', and its companion publication, FDA Technical Bulletin 3 (also known as Agriculture Handbook 655), entitled 'Insect and mite pests in Food: an illustrated key', were developed simultaneously and are intended to be used together. Both publications cover insects and mites, but this volume also includes major sections on the vertebrate pests of the food industry. The quantity of space devoted to the various pests reflects the relative importance of the different pest groups, rats, cockroaches and beetles receiving the most attention. Although other pest groups receive less attention, the aim is to provide sufficient information to make responsible and informed decisions regarding the management of pest populations. Following the introductory section, there are major sections on the following topics: ecology; prevention; survey and control; health considerations; regulation and inspection; and management. These sections contain 4, 16, 5, 9, 4, 7 and 5 contributions, resp., by different authors. Finally, there are taxonomic and subject indexes and a glossary.
KW - agricultural entomology
KW - Arthropod pests
KW - biodeterioration
KW - control
KW - ecology
KW - food industry
KW - Foods
KW - Insect pests
KW - pest control
KW - pests
KW - Stored products
KW - Stored products pests
KW - Vertebrate pests
KW - Blattaria
KW - Coleoptera
KW - insects
KW - Rats
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Blattodea
KW - pest arthropods
KW - pest insects
KW - storage pests
KW - stored-product pests
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Industry (EE520) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921159189&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation of nonnutritive sweeteners and other sugar substitutes.
AU - Glinsmann, W. H.
AU - Dennis, D. A.
T2 - Sugars and sweeteners.
Y1 - 1991///
CY - Boca Raton, FL 33431; USA
PB - CRC Press Inc.
AD - Glinsmann, W. H.: Division of Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Department of Health & Human Services, Washington, DC 20201, USA.
N1 - Accession Number: 19920310651. Publication Type: Book chapter. Language: English. Number of References: 47 ref. Subject Subsets: Sugar Industry; Human Nutrition
N2 - US legislation applying to sweeteners since 1938 is reviewed, and the status of each sweetener either approved or petitioned for food use (both intense sweeteners and sugar alcohols) is explained. Of the sugar alcohols, sorbitol is affirmed as GRAS (generally recognized as safe), whereas xylitol and mannitol are regulated as food additives; all 3 are permitted for broad use in food, but only sorbitol is used extensively - particularly in baked goods, frozen dairy products, soft confectionery and chewing gum. Petitions exist for maltitol, isomalt, lactitol and hydrogenated starch hydrolysate. The last has been used in hard confectionery without FDA approval; this and lactitol may find use primarily as bulking agents, texturizers and humectants rather than as sweeteners.
KW - Food legislation
KW - metabolism
KW - sugar alcohols
KW - sweeteners
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Sugar and Sugar Products (QQ020)
KW - Laws and Regulations (DD500)
KW - Food Composition and Quality (QQ500)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920310651&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Rickettsia rickettsii in saliva, haemolymph and triturated tissues of Dermacentor andersoni ticks by polymerase chain reaction.
AU - Gage, K. L.
AU - Gilmore, R. D.
AU - Karstens, R. H.
AU - Schwan, T. G.
JO - Molecular and Cellular Probes
JF - Molecular and Cellular Probes
Y1 - 1992///
VL - 6
IS - 4
SP - 333
EP - 341
SN - 0890-8508
AD - Gage, K. L.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1 - Accession Number: 19950802700. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Diagnostic assays using polymerase chain reaction (PCR) were developed for identifying rickettsial infections in ticks. The assays amplified a 500 bp fragment from the gene encoding the rOMP B protein of R. rickettsii. The selected primers amplified fragments of the predicted size from all spotted fever group rickettsiae tested. No amplified products were detected when typhus group rickettsiae were assayed. Using techniques described in this study, the predicted product was reliably amplified from saliva, haemolymph and triturated tissues of D. andersoni. Samples derived from infected ticks preserved in 70% ethanol also were suitable for amplification by PCR, but similar assays performed with infected ticks preserved in 5% buffered formalin seldom gave positive results.
KW - detection
KW - disease vectors
KW - polymerase chain reaction
KW - Rocky Mountain spotted fever
KW - tickborne diseases
KW - Acari
KW - Arachnida
KW - Dermacentor andersoni
KW - Ixodidae
KW - Rickettsia rickettsii
KW - Rickettsiaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802700&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of graded levels of high-molecular-weight carrageenan on colonic mucosal thymidine kinase activity.
AU - Calvert, R. J.
AU - Satchithanandam, S.
JO - Nutrition (Burbank)
JF - Nutrition (Burbank)
Y1 - 1992///
VL - 8
IS - 4
SP - 252
EP - 257
SN - 0899-9007
AD - Calvert, R. J.: Division of Nutrition, HFF-268, U.S. Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19931459306. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9000-07-1, 9002-06-6. Subject Subsets: Human Nutrition
N2 - Graded amounts of high-molecular-weight carrageenan were given to male Fischer 344 rats to investigate the effects of carrageenan on colonic cell proliferation. 4 groups of 7 rats consumed diets containing 0 (control), 0.65, 1.31, or 2.61% carrageenan ad libitum for 4 weeks. These amounts were designed to simulate 25, 50, and 100 times the maximal human carrageenan intake. After an overnight fast, the rats were anaesthetized, and the colonic mucosa was removed and homogenized. A supernatant was prepared and assayed for total protein and thymidine kinase activity (a marker for cell proliferation). Increasing amounts of carrageenan resulted in stepwise increases in total mucosal protein and in thymidine kinase specific (units/mg of protein) and total (units/cm of colon) activity. However, increases in thymidine kinase activity were significant only at the highest dose of carrageenan. No histological abnormalities were associated with any level of carrageenan feeding. The results suggest a clear dose-response increase in colonic mucosal cell proliferation with increasing doses of carrageenan; however, the effect at doses 19 times maximal human intake was not statistically different from that for control rats.
KW - Carrageenan
KW - cell division
KW - Colon
KW - fibre
KW - intake
KW - Intestinal mucosa
KW - mucosa
KW - Thymidine kinase
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fiber
KW - intestine epithelium
KW - karyokinesis
KW - mucous membrane
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459306&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total diet studies: the identification of core foods in the United States food supply.
AU - Pennington, J. A. T.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1992///
VL - 9
IS - 3
SP - 253
EP - 264
SN - 0265-203X
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19920455709. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Some total diet studies are based on the selection and analysis of core foods in a national or regional food supply. One way to select core foods is by computerized evaluation of the daily food intakes reported by subjects participating in national food consumption surveys. The foods consumed by the population groups of concern may be aggregated into core food groups. The foods within each group may be ranked according to daily intake and weight percentage of the total diet. The food that best represents each group may then be identified as a core food, and the daily consumption levels for each each food group may then be assigned to the core food representing the group. Consumption levels may be determined for the specific age-sex categories of concern. To assess the representativeness of core foods identified in this manner, the food composition database of the national survey may be used to determine nutrient intakes based on the full range of foods in the database vs. nutrient intakes based on the core foods. Foods mentioned include: milk and cheese; eggs; meat and fish; legumes; grains; fruit; vegetables; desserts; beverages; and infant foods.
KW - Cows
KW - diet studies
KW - Foods
KW - NUTRITION SURVEYS
KW - USA
KW - cattle
KW - Man
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional surveys
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920455709&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Proposal for an international interface standard for food databases.
AU - Pennington, J. A. T.
AU - Hendricks, T. C.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1992///
VL - 9
IS - 3
SP - 265
EP - 275
SN - 0265-203X
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19920455710. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - A database interface standard incorporating the food description language LANGUAL is under development to allow international exchange of food composition, food consumption, and other food-related data. The first step in this project is the refinement and implementation of a schema for the interface standard. This schema includes descriptive terms for LANGUAL factors and other aspects of foods. The second step is the development of a repertoire of personal computer programs for retrieval of food data, using the standard interface. The third step calls for the dissemination of the results of this project to an international audience through demonstration projects for international symposia and pilot tests for scientific applications.
KW - databases
KW - Foods
KW - standards
KW - data banks
KW - Food Science and Food Products (Human) (QQ000)
KW - Information and Documentation (CC300)
KW - Laws and Regulations (DD500)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920455710&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of sulphites determined in a variety of foods by the optimized Monier-Williams method.
AU - Daniels, D. H.
AU - Joe, F. L., Jr.
AU - Warner, C. R.
AU - Longfellow, S. D.
AU - Fazio, T.
AU - Diachenko, G. W.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1992///
VL - 9
IS - 4
SP - 283
EP - 289
SN - 0265-203X
AD - Daniels, D. H.: Division of Food Chemistry and Technology, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941408701. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - food additives
KW - food safety
KW - foods
KW - sulfites
KW - analytical techniques
KW - sulphites
KW - Techniques and Methodology (ZZ900)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Nutrition (General) (VV100)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941408701&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Putting the bST human-health controversy to rest.
AU - Miller, H. I.
JO - Bio/Technology
JF - Bio/Technology
Y1 - 1992///
VL - 10
IS - 2
SP - 147
EP - 147
SN - 0733-222X
AD - Miller, H. I.: Office of Biotechnology, Food and Drug Administration, Room 11-34, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19920194971. Publication Type: Journal Article. Language: English. Registry Number: 9002-72-6. Subject Subsets: Agricultural Biotechnology; Human Nutrition; Dairy Science
N2 - The evidence which led to the decision taken by the US Food and Drug Administration (FDA) that milk from cows injected with recombinant bovine somatotropin is safe for human consumption is discussed. It is concluded that although the issues of safety for cattle and the environment are still being considered, the safety of the product for humans has been endorsed by the scientific community.
KW - Biotechnology
KW - Cows
KW - food safety
KW - foods
KW - Milk
KW - milk consumption
KW - safety
KW - Somatotropin
KW - cattle
KW - MAN
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - growth hormone
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Occupational Health and Safety (VV900)
KW - Food Science and Food Products (Human) (QQ000)
KW - Social Sciences (General) (UU000)
KW - Laws and Regulations (DD500)
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920194971&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hypersensitivity pneumonitis and organic dust toxic syndrome.
AU - Parker, J. E.
AU - Petsonk, E. L.
AU - Weber, S. L.
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
Y1 - 1992///
VL - 12
IS - 2
SP - 279
EP - 290
SN - 0889-8561
AD - Parker, J. E.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health Centers for Disease Control, United States Public Health Service, Morgantown, WV 26505, USA.
N1 - Accession Number: 19931251097. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Clinical picture, radiography, diagnosis, pathology, pathogenesis and therapy of hypersensitivity pneumonitis, and clinical presentation, symptomatology, physical examination, prognosis and pathogenesis of organic dust toxic syndrome are discussed. Contrasts and similarities between the 2 conditions are considered.
KW - Occupational disorders
KW - reviews
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hypersensitivity pneumonitis
KW - Organic dust toxic syndrome
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251097&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fat substitutes: a regulatory perspective.
AU - Vanderveen, J. E.
AU - Glinsmann, W. H.
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
Y1 - 1992///
VL - 12
SP - 473
EP - 487
SN - 0199-9885
AD - Vanderveen, J. E.: Division of Nutrition, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941406480. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - Fat substitutes are reviewed focusing on their regulation. Discussion is under the headings: Safety requirements for foods; Fat substitutes from traditional food sources; Fat substitutes produced by chemical synthesis; Fats derived from novel sources; Total diet perspective; and Labelling of food containing fat substitutes.
KW - diet
KW - fats
KW - food legislation
KW - food safety
KW - lipid substitutes
KW - reviews
KW - sources
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Nutrition (General) (VV100)
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406480&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets.
AU - Zapisek, W. F.
AU - Cronin, G. M.
AU - Lyn-Cook, B. D.
AU - Poirier, L. A.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1992///
VL - 13
IS - 10
SP - 1869
EP - 1872
SN - 0143-3334
AD - Zapisek, W. F.: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19941403999. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 62-49-7, 63-68-3. Subject Subsets: Human Nutrition
N2 - Proto-oncogene hypomethylation in rat livers during early stages of hepatocarcinogenesis by dietary methyl deprivation in the presence and absence of initiation by diethylnitrosamine (DEN) was studied. Male weanling F344 rats were fed on a complete diet, or a diet deficient in methionine and choline (MDD). Half the rats in each dietary group were given a single initiating dose of DEN (20 mg/kg). Rats from each of the treatment groups were killed at 1, 3, 8, 16 and 32 weeks and hepatic DNA was isolated. This DNA was digested with restriction enzymes MspI and HpaII to determine the extent of methylation of the CCGG sequences in c-Ha-ras, c-Ki-ras and c-fos proto-oncogenes. Results indicated that administration of MDD produced hypomethylation of these proto-oncogenes at all times investigated, independent of DEN initiation. Methylation changes in the c-Ha-ras gene increased in intensity throughout the experiment until at 32 weeks they were similar to patterns seen in both neoplastic and preneoplastic livers of rats fed on the deficient diet for 18 months. The results demonstrate that early, selective hypomethylation of some, but not all, CCGG sites occurs in rats undergoing hepatocarcinogenesis by dietary methyl deprivation.
KW - amino acids
KW - carcinogenesis
KW - carcinoma
KW - choline
KW - deficiency
KW - liver
KW - methionine
KW - methylation
KW - neoplasms
KW - oncogenes
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403999&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pharmacokinetic data in the evaluation of the safety of food and color additives.
AU - Lin, C. S.
AU - Shoaf, S. E.
AU - Griffiths, J. C.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1992///
VL - 15
IS - 1
SP - 62
EP - 72
SN - 0273-2300
AD - Lin, C. S.: Division of Toxicological Review and Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931464235. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Human Nutrition
N2 - Safety evaluation of food and colour additives intended for human use is usually based on toxicity data from animal studies; human data are rarely available. The extrapolation of animal data to man is often controversial. The important role that pharmacokinetic data could play in the safety evaluation of food and colour additives is now widely recognized. The current scientific knowledge concerning the application of properly designed pharmacokinetic studies to the evaluation of the safety of food and colour additives is reviewed. In principle, pharmacokinetic data can be useful not only in designing, interpreting and extrapolating animal toxicity studies to man, but also in providing insight into the mechanisms of toxicity. Examples of such applications are provided.
KW - Food additives
KW - Food colourants
KW - pharmacokinetics
KW - reviews
KW - safety
KW - food colorants
KW - Food Additives (QQ130)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464235&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Optimization of an electrolytic conductivity detector for determination of toxic nitrogen-containing food contaminants separated by open tubular column gas chromatography.
AU - Fehringer, N. V.
AU - Gilvydis, D. M.
AU - Walters, S. M.
AU - Poole, C. F.
JO - HRC, Journal of High Resolution Chromatography
JF - HRC, Journal of High Resolution Chromatography
Y1 - 1992///
VL - 15
IS - 2
SP - 124
EP - 127
SN - 0935-6304
AD - Fehringer, N. V.: Pesticides and Industrial Chemicals Research Center, US Food and Drug Administration, 1560 E Jefferson Avenue, Detroit, MI 48207, USA.
N1 - Accession Number: 19951400913. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - food contamination
KW - foods
KW - organic nitrogen compounds
KW - pesticide residues
KW - toxic substances
KW - analytical techniques
KW - food contaminants
KW - poisons
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400913&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - N,N′-diethyl-m-toluamide (m-DET): analysis of an insect repellent in human urine and serum by high-performance liquid chromatography.
AU - Smallwood, A. W.
AU - DeBord, K. E.
AU - Lowry, K. L.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 1992///
VL - 16
IS - 1
SP - 10
EP - 13
SN - 0146-4760
AD - Smallwood, A. W.: Food and Drug Administration, National Forensic Chemistry Center, 1141 West Central Parkway, Cincinnati, OH 45202, USA.
N1 - Accession Number: 19920510432. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 134-62-3. Subject Subsets: Medical & Veterinary Entomology
N2 - A procedure for monitoring diethyltoluamide (Deet) in human urine and serum is described. Deet was removed from the urine specimen by partitioning into diethyl ether, but solid-phase extraction was used to remove it from human serum. The urine and serum Deet values were determined by HPLC with a UV detector. The limit of detection was 0.09 µg/ml in urine and 0.09 µg/g for serum. The recovery of Deet from human urine, spiked between 0.50 and 8.00 µg/ml, was 90±5.4%. For human serum, spiked between 0.25 and 10.00, recovery was 96±5.9%. The pooled relative standard deviations for spiked matrices were 0.06 for both urine and serum.
KW - analytical methods
KW - Diethyltoluamide
KW - HPLC
KW - Insect repellents
KW - pesticide residues
KW - residues
KW - Serum
KW - Urine
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - DEET
KW - high performance liquid chromatography
KW - Repellents and Attractants (HH500)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920510432&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Codex committee on pesticide residues - a plan for improved participation by governments.
AU - Wessel, J. R.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1992///
VL - 16
IS - 2
SP - 126
EP - 149
SN - 0273-2300
AD - Wessel, J. R.: Office of Regulatory Affairs, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19950507969. Publication Type: Journal Article. Language: English. Number of References: 26 ref.
N2 - A plan of action is proposed which allows countries to selectively accept Codex maximum residue limits, increase the number of chemicals in the JMPR/CCPR system for evaluation, and be responsive to both their consumers and their food producers without compromising national health and safety standards and competitive trade advantages.
KW - food
KW - pesticide residues
KW - pesticides
KW - policy
KW - residues
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507969&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Validation studies on an in vitro semicontinuous culture system designed to simulate a bacterial ecosystem of the human intestine.
AU - Campbell, W. L.
AU - Franklin, W.
AU - Cerniglia, C. E.
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 1992///
VL - 16
IS - 4
SP - 239
EP - 252
SN - 0167-7012
AD - Campbell, W. L.: Microbiology Division, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.
N1 - Accession Number: 19931464843. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - A semicontinuous culture system (SCCS) inoculated with human intestinal bacteria was used to determine whether metabolic activity in the human intestine could be maintained in vitro. After 43 days, a diverse bacterial population was still present with counts above 4 × 109 bacteria/ml. Bacteroides spp. accounted for approximately 50% of the colonies isolated. Other isolates included Eubacterium, Fusobacterium, Peptostreptococcus, Lactobacillus, Peptococcus, Clostridium, Streptococcus, and Acidaminococcus spp. Acetic, propionic and butyric acid made up over 90% of the volatile fatty acids. β-Glucosidase, β-glucuronidase, nitroreductase and azoreductase, which were present in the inoculum, were also present after 43 days. Carbon dioxide was the predominant gas (17.81 mmol/litre). Hydrogen and methane were detected at 0.66 mmol/litre, respectively. After 17 days, the azo dye Direct blue 15, was added to the culture and over 90% was metabolized in the first 24 h. Two metabolites, 3,3′-dimethoxybenzidine and 4-amino-3,3′-dimethoxybiphenyl, were isolated and identified by high pressure liquid chromatography (HPLC), gas chromatography and mass spectrometry. Results indicate that diverse metabolically active cultures can be maintained for prolonged periods and used for studies of xenobiotic metabolism.
KW - in vitro
KW - intestinal microorganisms
KW - metabolism
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gut flora
KW - intestinal micro-organisms
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464843&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food contaminants: scientific and public health implications.
AU - Pohland, A. E.
AU - Yess, N. J.
JO - Proceedings of the Nutrition Society of Australia
JF - Proceedings of the Nutrition Society of Australia
Y1 - 1992///
VL - 17
SP - 1
EP - 12
SN - 0314-1004
AD - Pohland, A. E.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington DC, USA.
N1 - Accession Number: 19931459817. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - The types of contaminants in foods causing food safety concerns include those of microbial origin (mycotoxins, phycotoxins) and industrial origin (PCBs, lead, dioxins, radionuclides), residues (pesticides, animal drugs), intrinsic toxicants (phytoalexins, allelochemicals, pyrrolizidine alkaloids, glycoalkaloids), and food additives (direct or indirect). The ability to determine the presence and analyse the concentrations of these contaminants in food products, with confidence, is discussed.
KW - Antinutritional factors
KW - Drug residues
KW - estimation
KW - Food additives
KW - Food contamination
KW - Mycotoxins
KW - Pesticides
KW - public health
KW - Australia
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - food contaminants
KW - fungal toxins
KW - Proceedings of the Nutrition Society
KW - Pesticides and Drugs (General) (HH400)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931459817&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet.
AU - Fullerton, F. R.
AU - Greenman, D. L.
AU - Bucci, T. J.
JO - Fundamental and Applied Toxicology
JF - Fundamental and Applied Toxicology
Y1 - 1992///
VL - 18
IS - 2
SP - 193
EP - 199
SN - 0272-0590
AD - Fullerton, F. R.: National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19931465973. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - 2 diets used in toxicological and/or nutritional studies were compared with respect to their influence on growth, body growth, lifespan, spontaneous neoplasia, and neoplastic responses to 2-acetylaminofluorene (2-AAF) in both sexes of weaning mice. The mice were fed on a purified diet or a nonpurified, natural ingredient diet, without or with 2-AAF for up to 2 years. The results showed the importance of diet selection on the outcome of carcinogenicity studies. However, the results suggested that dietary differences may not be consistently found among different sexes or strains and that differences between purified and nonpurified diets in the carcinogenic response to a carcinogen may be related to their differential effect on body weight.
KW - bladder
KW - Body weight
KW - Carcinogenesis
KW - diet
KW - Diets
KW - Growth
KW - Lifespan
KW - liver
KW - Neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - urinary bladder
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465973&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Treatment of chloroquine-resistant malaria in African children: a cost-effectiveness analysis.
AU - Sudre, P.
AU - Breman, J. G.
AU - McFarland, D.
AU - Koplan, J. P.
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Y1 - 1992///
VL - 21
IS - 1
SP - 146
EP - 154
SN - 0300-5771
AD - Sudre, P.: Malaria Branch (F-12), Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19932020370. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 69-44-3, 50-63-8, 54-05-7, 86-42-0, 132-73-0. Subject Subsets: Protozoology; Tropical Diseases
N2 - Because chloroquine (Cq)-resistant Plasmodium falciparum (CRPF) has now spread throughout most of Africa, the efficacy and practicability of other drugs such as amodiaquine (Aq), and pyrimethamine-sulfadoxine (PS), for the treatment of fever needs to be assessed. [The authors] used a decision-analysis model to compare the cost and effectiveness of Cq, Aq, and PS. The variables considered were the probability of P. falciparum infection, drug compliance, minor and lethal side effects of the drug, the level of drug resistance in the community, and case-fatality rates associated with treatment. The measures of effectiveness were the number of malaria-related fever episodes cured parasitologically with each treatment and the number of malaria deaths prevented in children 6-59 months old. Cost-effectiveness comparisons were made for cases cured and deaths prevented. For treating 100 000 febrile episodes, Cq, PS, and Aq cost US $1812, US $2622 and US $3044, respectively. Cost of the drug, compliance, and the level of CRPF had the greatest effect on the cost-effectiveness ratio. The prevalence of high-level drug resistance (RIII) was the most important determinant of the cost-effectiveness. In a scenario with high-level CRPF, treatment with Cq costs US $0.47 to cure one patient and US $2.29 to prevent one death compared with US $0.05 and US $1.52 for treatment with PS. When the prevalence of RIII-level CRPF is greater than 14-31% (depending on the level of compliance), the most cost-effective treatment is PS, despite its 45% greater cost. Decision-analysis models will be useful for malaria control planners as strategies are reconsidered in the 1990s. AS<new para>ADDITIONAL ABSTRACT:<new para>Because chloroquine (Cq)-resistant Plasmodium falciparum (CRPF) has now spread throughout most of Africa, the efficacy and practicability of other drugs such as amodiaquine (Aq), and pyrimethamine-sulfadoxine (PS), for the treatment of fever needs to be assessed. A decision-analysis model was used to compare the cost and effectiveness of Cq, Aq, and PS. The variables considered were the probability of P. falciparum infection, drug compliance, minor and lethal side effects of the drug, the level of drug resistance in the community, and case-fatality rates associated with treatment. The measures of effectiveness were the number of malaria-related episodes cured parasitologically with each treatment and the number of malaria deaths prevented in children 6-59 months old. Cost-effectiveness comparisons were made for cases cured and deaths prevented. For treating 100 000 febrile episodes, Cq, PS, and Aq cost US$1812, US$2622, and US$3044, respectively. Cost of the drug, compliance, and the level of CRPF had the greatest effect on the cost-effectiveness ratio. The prevalence of high-level drug resistance (RIII) was the most important determinant of the cost-effectiveness. In a scenario with high-level CRPF, treatment with Cq costs US$0.47 to cure one patient and US$2.29 to prevent one death compared with US$0.05 and US$1.52 for treatment with PS. When the prevalence of RIII-level CRPF is greater than 14-31% (depending on the level of compliance), the most cost-effective treatment is PS, despite its 45% greater cost.
KW - Amodiaquine
KW - Antimalarials
KW - Antiprotozoal agents
KW - children
KW - chloroquine
KW - cost benefit analysis
KW - drug resistance
KW - drug therapy
KW - Human diseases
KW - malaria
KW - parasites
KW - resistance
KW - treatment
KW - Africa
KW - Apicomplexa
KW - man
KW - Plasmodiidae
KW - Plasmodium falciparum
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - chemotherapy
KW - falciparum malaria
KW - Pyrimethamine sulfadoxine
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020370&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Outbreak of hypersensitivity pneumonitis among mushroom farm workers.
AU - Sanderson, W.
AU - Kullman, G.
AU - Sastre, J.
AU - Olenchock, S.
AU - O'Campo, A.
AU - Musgrave, K.
AU - Green, F.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1992///
VL - 22
IS - 6
SP - 859
EP - 872
SN - 0271-3586
AD - Sanderson, W.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
N1 - Accession Number: 19931251137. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Seven cases of mushroom worker's lung (MWL) were diagnosed among workers (4 men, 3 women, aged 24-52 yr) at a mushroom farm in Florida during Apr. 1982-Aug. 1985. The patients suffered from episodic shortness of breath, cough, fever and chills, myalgia, malaise and difficulty breathing. Pulmonary function testing revealed restrictive ventilatory impairment and reduced diffusing capacity; chest radiographs showed diffuse interstitial pulmonary infiltrates. Six of the affected workers left employment at the farm in order to remain free of symptoms, while 1 worker remained at the farm in a maintenance shop which was physically separated from the rest of the farm facilities. An industrial hygiene survey demonstrated that workers in every work area were exposed to organic dust constituents suspected of causing MWL, but no specific antigens were identified as the cause of the cases. A cross-sectional respiratory morbidity study found that approx. 20% (of 259) of more heavily exposed workers at the farm occasionally experienced symptoms consistent with MWL, and approx. 10% had below normal spirometry test results. No abnormalities consistent with either acute or chronic MWL were seen on the chest radiographs. Serological tests to extracts of 13 different materials used in mushroom growing, 15 spp. of thermophilic actinomycetes and fungi isolated from the farm, Agaricus bisporus and pesticide showed that almost all workers had been exposed to antigens capable of causing MWL, but the results were not associated with health status. At the time of the survey no workers were suffering from acute respiratory problems consistent with MWL.
KW - hosts
KW - Occupational disorders
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mushroom worker's lung
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931251137&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition shelf-labeling and consumer purchase behavior.
AU - Schucker, R. E.
AU - Levy, A. S.
AU - Tenney, J. E.
AU - Mathews, O.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1992///
VL - 24
IS - 2
SP - 75
EP - 81
SN - 0022-3182
AD - Schucker, R. E.: Division of Consumer Studies, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931456565. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - A nutrition information programme consisting of brand-specific nutrition shelf-tags and a supplementary explanatory booklet, was tested for 2 years in Baltimore, USA, stores of the Giant Food chain, replicating a previous successful trial of the programme in Washington, DC. During the 2-year evaluation, market shares of shelf-tagged products increased 12% on average in Baltimore stores in 8 of 16 product categories that had been included in the original programme trial. The largest market share increases occurred for products with the most flagged nutrients. Products with fewer flagged nutrients actually lost market share, suggesting that shopper purchases tended to be influenced by the number of featured nutrients as well as by the nature of the nutrients themselves. Responses to a shopper survey as well as the sales data converged to indicate that shopper concerns about nutrition and health status of family members are more highly correlated with programme use than are education, income and age.
KW - Foods
KW - labelling
KW - purchasing habits
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456565&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The 1990 revision of the FDA Total Diet Study.
AU - Pennington, J. A. T.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1992///
VL - 24
IS - 4
SP - 173
EP - 178
SN - 0022-3182
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951401710. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - Information from the 1987-88 USDA Nationwide Food Consumption Survey (NFCS) was used to revise the food list and diets of the Food and Drug Administration's Total Diet Study. The 1990 Total Diet Study contained 265 core foods that would be used to estimate contaminant and nutrient intakes for 14 age-sex categories. The core foods were selected by aggregating the foods consumed by the selected age-sex categories into 265 groups. A food within each group was selected to represent the group. For each age-sex category, the daily gram weight intake of each food within each group was assigned to the core food. These estimates of daily intakes of the 265 foods represented approximately the same weight and caloric intake of average diets for the 14 age-sex categories using 3571 foods of the NFCS database. Nutrient intakes of diets calculated on the basis of the 3571 foods and the 265 Total Diet Study foods were similar.
KW - composition
KW - diet studies
KW - food legislation
KW - food safety
KW - foods
KW - nutrition surveys
KW - nutritional state
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - nutritional status
KW - nutritional surveys
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951401710&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of reading nutrition and ingredient information on food labels among adult Americans: 1982-1988.
AU - Bender, M. M.
AU - Derby, B. M.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1992///
VL - 24
IS - 6
SP - 292
EP - 297
SN - 0022-3182
AD - Bender, M. M.: Division of Consumer Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19931457740. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 22 ref. Subject Subsets: Human Nutrition
N2 - Comparisons of 5 US Food and Drug Administration Health and Diet Surveys in the 1980s provide estimates of the numbers of consumers who report that they pay attention to ingredient lists and nutrition labels and identify trends based on replicated measures. Recent estimates indicate that more than 4 of 5 USA consumers report that they pay attention to one or both types of label information, with just under 75% reporting use of each individual information source. There was no net increase in consumer use of the food label ingredient list from 1982 to 1986, but use of the nutrition label increased significantly. Consumers who use both types of labels are more likely to be young (25 to 34 years old), white, female, better educated, and to follow a self-initiated or doctor-prescribed low-sodium or low-cholesterol diet. Educators now face a challenge to address remaining knowledge gaps, particularly among population groups who are less likely to use labels, and to develop practical strategies to help all consumers make more effective use of food label information in dietary management.
KW - consumer attitudes
KW - Foods
KW - labelling
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931457740&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bactericidal activities of tri- and penta-iodinated resins against Legionella pneumophila.
AU - Sanden, G. N.
AU - Fields, B. S.
AU - Barbaree, J. M.
AU - Morrill, W. E.
AU - Feeley, J. C.
JO - Water Research (Oxford)
JF - Water Research (Oxford)
Y1 - 1992///
VL - 26
IS - 3
SP - 365
EP - 370
SN - 0043-1354
AD - Sanden, G. N.: Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19921375310. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 7732-18-5.
N2 - Quaternary-ammonium-anion-exchange resins binding tri-iodides or penta-iodides were tested for their ability to disinfect water containing L. pneumophila. Results indicated that the iodinated resins are stable demand-release disinfectants. No residual iodine was detected by amperometric titration in the eluate from tri-iodinated or washed penta-iodinated resins. When an aq. suspension containing 2.7 × 109 cfu of L. pneumophila/ml was passed through tri-iodinated resins, < 0.004% were recovered. No viable cells were detected by direct plating from a suspension of 2.3 × 109 cfu/ml eluted through penta-iodinated resins (> 99.99999% viability reduction). This disinfectant was less effective if legionellae were ingested by Tetrahymena pyriformis before exposure. Penta-iodinated resins were also less active at 42°C, when tested with water designed to inhibit halogen disinfectants and waters containing high concn of organic matter or total dissolved solids. Further study of penta-iodinated resins as a disinfectant of potable water containing L. pneumophila is warranted.
KW - biodeterioration
KW - control
KW - pathogens
KW - Water
KW - Bacteria
KW - Legionella pneumophila
KW - prokaryotes
KW - Legionella
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Iodinated resins
KW - Biodeterioration (SS300)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921375310&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced inhibition of viral interferon induction by bioactivated aflatoxins.
AU - Hahon, N.
AU - Chen, J. K.
JO - Journal of Environmental Science and Health. Part A, Environmental Science and Engineering
JF - Journal of Environmental Science and Health. Part A, Environmental Science and Engineering
Y1 - 1992///
VL - 27
IS - 8
SP - 2281
EP - 2299
SN - 0360-1226
AD - Hahon, N.: National Institute of Occupational Safety and Health, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 19931215000. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The inhibition by aflatoxins B and G, enzymatically bioactivated by rat liver homogenate, of interferon-α/β induction by influenza virus in rhesus monkey kidney (LLC-MK2) cell monolayers was studied. Inhibition of interferon induction followed a structure-activity series with decreasing potency of aflatoxin B1 > G1 > B2 > G2 by both non-activated and bioactivated aflatoxins. The quantity of bioactivated aflatoxin of all types required to achieve 50% inhibition of interferon induction was 4-fold less than that of aflatoxins alone. Dose-response relationships were seen between aflatoxin quantity and interferon inhibition under all conditions relative to aflatoxin type and bioactivation status. That higher levels of Sendai virus growth were attained in non-activated and bioactivated aflatoxin (B1 and G2)-pretreated cells than in untreated cell monolayers, was related to decreased production of interferons by aflatoxins. The ability of interferon to confer cellular resistance against viral infection was not impaired by aflatoxins (bioactivated or non-activated). It is suggested that bioactivating toxins enhances their ability to inhibit viral induction of interferon-α/β.
KW - Aflatoxins
KW - immunosuppression
KW - Mycotoxins
KW - toxicity
KW - fungal toxins
KW - Plant Composition (FF040)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931215000&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary alteration in the rates of cancer and aging.
AU - Turturro, A.
AU - Hart, R.
JO - Experimental Gerontology
JF - Experimental Gerontology
Y1 - 1992///
VL - 27
IS - 5/6
SP - 583
EP - 592
SN - 0531-5565
AD - Turturro, A.: National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951402216. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - Both variation of diet and comparative analysis were used to evaluate the effects of nutrition on mortality and cancer. The effects of caloric restriction (CR) were compared in multiple strains raised under similar conditions for a diet developed to assist breeding, and for a standard diet. A standard analysis, using "aging rates" was of limited use for understanding the effects of CR in delaying mortality in certain strains. However, when the effect of the diets on body weight and the known effects on sex-specific P-450 isoenzyme expression were compared, these effects suggested a mechanism for the action of CR. By comparative analysis, the effect of CR on tumour pathology suggested that the same mechanisms responsible for inhibiting reproduction may be responsible for delaying the aging-related increase in incidence of diseases. Based on these data, the adaptive/longevity-related process theory of CR was modified to incorporate aspects of the disposable soma theory of aging, as well as pleiotropism.
KW - aging
KW - animal models
KW - carcinoma
KW - diet
KW - energy deprivation
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402216&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Argas (Argas) monolakensis, new species (Acari: Ixodoidea: Argasidae), a parasite of California gulls on islands in Mono Lake, California: description, biology, and life cycle.
AU - Schwan, T. G.
AU - Corwin, M. D.
AU - Brown, S. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1992///
VL - 29
IS - 1
SP - 78
EP - 97
SN - 0022-2585
AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930513993. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Argas monolakensis sp. nov. is described from adults, nymphs and larvae collected from under and around nests of California gulls (Larus californicus) on islands in Mono Lake, Mono County, California, USA, and from specimens reared in the laboratory. This species is closely related to A. cooleyi, a parasite of cliff swallows (Hirundo pyrrhonota), but is easily distinguished by hypostome dentition and roof of Haller's organ in all stages and chaetotaxy of the larvae. This tick was successfully reared and maintained in the laboratory by feeding them on domestic chickens. Larvae require 5-8 days to feed, whereas all postlarval stages feed rapidly within 9-62 min. At Mono Lake, ticks are above ground and seek hosts only at night. The number of nymphal stages varies from 2 to 5 depending on the developmental temperature and sex of the tick. Ticks overwinter at Mono Lake as 2nd- to 5th-stage nymphs and adults. Ovarian diapause is common with preoviposition periods in extreme cases lasting up to 20 months. This tick will readily feed on humans and has the potential to transmit Mono Lake virus (Orbivirus), which has been isolated from an estimated 2-8% of ticks on various islands.
KW - Arboviruses
KW - Biology
KW - Development
KW - Diapause
KW - Disease vectors
KW - Ecology
KW - Ectoparasites
KW - Hosts
KW - new species
KW - poultry
KW - taxonomy
KW - wild animals
KW - Wild birds
KW - California
KW - North America
KW - USA
KW - Acari
KW - Arachnida
KW - Argasidae
KW - Birds
KW - fowls
KW - Laridae
KW - Larus californicus
KW - Man
KW - Orbivirus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Metastigmata
KW - Acari
KW - vertebrates
KW - Chordata
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Charadriiformes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Argas
KW - Argasidae
KW - Larus
KW - Laridae
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Argas monolakensis
KW - arthropod-borne viruses
KW - chickens
KW - domesticated birds
KW - Mono Lake virus
KW - systematics
KW - United States of America
KW - Taxonomy and Evolution (ZZ380)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513993&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Xenopsylla bantorum is an East African subspecies of X. cheopis (Siphonaptera: Pulicidae).
AU - Schwan, T. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1992///
VL - 29
IS - 6
SP - 927
EP - 933
SN - 0022-2585
AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930513311. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The geographic distribution, host associations, and male genital morphology of X. bantorum were examined and compared with the Nilotic and Oriental "strains" of X. cheopis. The more acute shape of the 9th sternite separates X. bantorum from all types of X. cheopis; however, the length of the first process of the male's clasper and the number of setae on this process are significantly different among all 3 groups; the Nilotic strain of X. cheopis is intermediate to the others. Specimens collected from both wild and commensal rodents in Nakuru, Kenya, were all X. bantorum, suggesting that X. cheopis present early in the century that resulted from introductions on Rattus rattus had been absorbed by the native X. bantorum population. These factors and a review of opinions by others concerning the status of X. bantorum demonstrate that this flea is not specifically distinct from X. cheopis. The trinomial X. cheopis bantorum is erected. Furthermore, the Nilotic and Oriental "strains" of X. cheopis are distinguishable morphologically solely by the length of the male's first process.
KW - Ectoparasites
KW - Geographical distribution
KW - Hosts
KW - Morphotaxonomy
KW - NEW RANK
KW - nomenclature
KW - Small mammals
KW - taxonomy
KW - Wild animals
KW - Africa
KW - East Africa
KW - Ethiopia
KW - Kenya
KW - Arvicanthis niloticus
KW - Mastomys natalensis
KW - Muridae
KW - Pulicidae
KW - Rattus rattus
KW - Rodents
KW - Siphonaptera
KW - Xenopsylla bantorum
KW - Xenopsylla cheopis
KW - Arvicanthis
KW - Murinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Rattus
KW - Xenopsylla
KW - Pulicidae
KW - Xenopsylla cheopis
KW - Africa South of Sahara
KW - Africa
KW - ACP Countries
KW - East Africa
KW - Least Developed Countries
KW - Developing Countries
KW - Anglophone Africa
KW - Commonwealth of Nations
KW - Mastomys
KW - Abyssinia
KW - black rat
KW - new status
KW - Oriental rat flea
KW - PRAOMYS NATALENSIS
KW - ship rat
KW - subspecies
KW - systematics
KW - Xenopsylla cheopis bantorum
KW - Biological Resources (Animal) (PP710)
KW - Taxonomy and Evolution (ZZ380)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930513311&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Levels of bacteria, fungi and endotoxin in stored timber.
AU - Dutkiewicz, J.
AU - Sorenson, W. G.
AU - Lewis, D. M.
AU - Olenchock, A.
JO - International Biodeterioration & Biodegradation
JF - International Biodeterioration & Biodegradation
Y1 - 1992///
VL - 30
IS - 1
SP - 29
EP - 46
SN - 0964-8305
AD - Dutkiewicz, J.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA.
N1 - Accession Number: 19950602036. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Forest Products
N2 - A paper presented at the Eighth International Biodeterioration Symposium, 26-31 August, 1990, Windsor, Ontario, Canada. Samples of 6 species (Tilia americana, Prunus serotina, Robinia pseudoacacia, Quercus coccinea, Acer saccharinum and Populus alba) were examined for total aerobic bacteria, gram-negative bacteria and fungi in heartwood, sapwood and bark in each of the 4 seasons. Results indicated that the microflora of apparently undecayed timber may reach high levels and may contain allergenic and/or toxic species which pose a potential risk for sawmill workers.
KW - endotoxins
KW - health hazards
KW - stored wood
KW - USA
KW - Acer saccharinum
KW - bacteria
KW - fungi
KW - Populus alba
KW - Prunus serotina
KW - Quercus coccinea
KW - Robinia pseudoacacia
KW - Tilia americana
KW - Acer
KW - Aceraceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - prokaryotes
KW - Populus
KW - Salicaceae
KW - Salicales
KW - Prunus
KW - Rosaceae
KW - Rosales
KW - Quercus
KW - Fagaceae
KW - Fagales
KW - Robinia
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Tilia
KW - Tiliaceae
KW - Malvales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American basswood
KW - American lime
KW - American linden
KW - bacterium
KW - black cherry
KW - black locust
KW - false acacia
KW - maples
KW - oaks
KW - scarlet oak
KW - silver maple
KW - United States of America
KW - white poplar
KW - Forest Products and Industries (General) (KK500)
KW - Occupational Health and Safety (VV900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950602036&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of polymerase chain reaction primer sets for diagnosis of Lyme disease and for species-specific identification of Lyme disease isolates by 16S rRNA signature nucleotide analysis.
AU - Marconi, R. T.
AU - Garon, C. F.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1992///
VL - 30
IS - 11
SP - 2830
EP - 2834
SN - 0095-1137
AD - Marconi, R. T.: Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, Department of Health and Human Services, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930518654. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
N2 - Partial 16S rRNA sequences from 23 Lyme disease spirochaete isolates were determined and compared, and aligned with 8 sequences previously presented. The 16S rRNA signature nucleotide compositions were defined for each isolate and compared with the genomic species signature nucleotide sets previously established. To identify positions truly indicative of species classification which could serve as targets for polymerase chain reaction (PCR) species-specific identification primers, 16S rRNA-based phylogenetic analyses were conducted. On the basis of the identified signature nucleotides, PCR primer sets were designed which amplified all spirochaete species associated with Lyme disease and differentiated between these species. The primer sets were tested on 38 Borrelia isolates associated with Lyme disease and were found to be sensitive and specific. All Lyme disease isolates tested were amplification positive. These primers allowed for the rapid species identification of Lyme disease isolates.
KW - Diagnosis
KW - Diagnostic techniques
KW - identification
KW - Lyme disease
KW - Nucleotide sequences
KW - polymerase chain reaction
KW - RNA
KW - France
KW - Germany
KW - Japan
KW - Russia
KW - Sweden
KW - Switzerland
KW - USA
KW - Borrelia burgdorferi
KW - Borrelia garinii
KW - Man
KW - Spirochaetaceae
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - APEC countries
KW - East Asia
KW - Asia
KW - Scandinavia
KW - Northern Europe
KW - EFTA
KW - North America
KW - America
KW - bacterium
KW - DNA sequences
KW - lyme borreliosis
KW - PCR
KW - ribonucleic acid
KW - Russian Federation
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518654&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perspectives on toxicological risk - an example: foodborne carcinogenic risk.
AU - Scheuplein, R. J.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1992///
VL - 32
IS - 2
SP - 105
EP - 121
SN - 1040-8398
AD - Scheuplein, R. J.: Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19941405075. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Human Nutrition
KW - carcinogenesis
KW - carcinogens
KW - carcinoma
KW - food additives
KW - food contamination
KW - foods
KW - neoplasms
KW - reviews
KW - risk
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - food contaminants
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405075&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Overview of FDA's Redbook Guidelines.
AU - Kokoski, C. J.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1992///
VL - 32
IS - 2
SP - 161
EP - 163
SN - 1040-8398
AD - Kokoski, C. J.: Division of Toxicological Review and Evaluation, Center for Food Safety and Applied Nutrition, FDA, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941405079. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
KW - food additives
KW - food industry
KW - food safety
KW - government organizations
KW - guidelines
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - recommendations
KW - United States of America
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405079&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Revisions to the FDA's Redbook Guidelines for toxicity testing: neurotoxicity.
AU - Sobotka, T. J.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1992///
VL - 32
IS - 2
SP - 165
EP - 171
SN - 1040-8398
AD - Sobotka, T. J.: Center for Food Safety and Applied Nutrition, Food and Drug Aministration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19941405080. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
KW - food additives
KW - food colourants
KW - food safety
KW - foods
KW - government organizations
KW - guidelines
KW - neurotoxins
KW - reviews
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food colorants
KW - recommendations
KW - United States of America
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405080&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Testing guidelines for evaluation of the immunotoxic potential of direct food additives.
AU - Hinton, D. M.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1992///
VL - 32
IS - 2
SP - 173
EP - 190
SN - 1040-8398
AD - Hinton, D. M.: Division of Toxicological Studies (HFF-162), Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, FDA, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19941405082. Publication Type: Journal Article. Language: English. Number of References: 89 ref. Subject Subsets: Human Nutrition
KW - food additives
KW - food safety
KW - foods
KW - guidelines
KW - immune system
KW - reviews
KW - toxicity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - recommendations
KW - United States of America
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405082&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating the safety of food and color additives with pharmacokinetic data.
AU - Lin, C. S.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1992///
VL - 32
IS - 2
SP - 191
EP - 195
SN - 1040-8398
AD - Lin, C. S.: Division of Toxicological Review and Evaluation, Center for Food Safety and Applied Nutrition, FDA, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941405081. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
KW - assessment
KW - food additives
KW - food colourants
KW - food safety
KW - foods
KW - pharmacokinetics
KW - reviews
KW - safety
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food colorants
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405081&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining drug dosages by height: applying a model made for coastal children in Papua New Guinea to children from the highlands.
AU - Zind, B. J.
JO - Papua New Guinea Medical Journal
JF - Papua New Guinea Medical Journal
Y1 - 1992///
VL - 35
IS - 3
SP - 194
EP - 196
SN - 0031-1480
AD - Zind, B. J.: Chinle Indian Health Service Hospital, PO Box PH, Chinle, AZ 86503, USA.
N1 - Accession Number: 19932020506. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases
N2 - A height scale for the determination of drug dosages in children of the Madang area was applied [in 1986] to children from the Nipa area of Papua New Guinea highlands. In only 13 out of 1314 children (1.0%) did the use of the height scale result in drug doses below the recommended minimum dose per kilogram of body weight. The scale can therefore be used safely for highlands children in areas where facilities for accurate weighing are not available.AS
KW - children
KW - dosage
KW - Drugs
KW - Pacific Islands
KW - Papua New Guinea
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Oceania
KW - ACP Countries
KW - APEC countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - New Guinea
KW - Melanesia
KW - Australasia
KW - Pacific Islands
KW - height scale
KW - medicines
KW - pharmaceuticals
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020506&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recommendations for prophylaxis against Pneumocystis carinii pneumonia for adults and adolescents infected with human immunodeficiency virus.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1992///
VL - 41
IS - 4
SP - iii + 11
EP - iii + 11
SN - 0149-2195
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930804550. Publication Type: Journal Article. Corporate Author: USA, Public Health Service Task Force on Antipneumocystis Prophylaxis for Patients with Human Immunodeficiency Virus Infection Language: English. Number of References: 35 ref. Registry Number: 100-33-4, 140-64-7. Subject Subsets: Protozoology
N2 - Recommendations for prophylaxis against P. carinii pneumonia (PCP) are presented. For adults and adolescents trimethoprim-sulfamethoxazole (TMP-SMX) (but without leucovorin) is recommended. For those patients unable to tolerate TMP-SMX, aerosolized pentamidine is recommended. Prophylactic regimens, adverse reactions, monitoring, and breakthrough PCP are discussed. Although no controlled trials of prophylaxis have been completed among children, the working group agreed that prophylaxis was warranted, and that TMP-SMX was the preferred regimen.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Aerosols
KW - Antiprotozoal agents
KW - Children
KW - Human diseases
KW - human immunodeficiency viruses
KW - Immunocompromised hosts
KW - Opportunistic infections
KW - parasites
KW - Pentamidine
KW - prophylaxis
KW - North America
KW - USA
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - protozoa
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - invertebrates
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - AIDS
KW - fungus
KW - human immunodeficiency virus
KW - Trimethoprim sulfamethoxazole
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804550&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Imported dengue - United States, 1991.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1992///
VL - 41
IS - 39
SP - 725
EP - 732
SN - 0149-2195
AD - US Department of Health and Human Services/Public Health Service.
N1 - Accession Number: 19940806274. Publication Type: Journal Article. Corporate Author: Centers for Disease Control Language: English. Number of References: 3 ref.
N2 - Serum samples from 82 persons with suspected imported dengue who had onset in 1991 were submitted to the Centers for Disease Control from 27 states and the District of Columbia, USA. Of these, 25 (34%) cases (from 18 states) were serologically or virologically diagnosed as dengue. 11 of the cases were acquired in Asia, 7 in the Caribbean, 4 in Central America, and one each in Tahiti and in an unspecified location in Latin America. This report summarizes those cases. In an editorial note, the epidemiology is briefly discussed.
KW - arboviruses
KW - case reports
KW - epidemiology
KW - human diseases
KW - imported infections
KW - travel medicine
KW - USA
KW - dengue virus
KW - Flavivirus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - arthropod-borne viruses
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pneumonic plague - Arizona, 1992.
AU - Opulski, A.
AU - MacNeill, E.
AU - Rosales, C.
AU - Hartsough, A.
AU - Doll, J.
AU - Levy, C.
AU - Fink, M.
AU - Erickson, B.
AU - Slanta, W.
AU - Cage, G.
AU - Gentry, G.
AU - Sands, L.
AU - Davis, T.
AU - Pape, J.
AU - Hoffman, R. E.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1992///
VL - 41
IS - 40
SP - 737
EP - 739
SN - 0149-2195
AD - Opulski, A.: US Department of Health and Human Services/Public Health Service, USA.
N1 - Accession Number: 19940806273. Publication Type: Journal Article. Corporate Author: Centers for Disease Control Language: English. Number of References: 6 ref.
N2 - On August 26, 1992, a 31-year-old resident of Tucson, Arizona, died of an illness subsequently diagnosed as primary pneumonic plague. This was the 10th case of plague reported in the USA in 1992 and the first pneumonic plague case that year. It was also the first plague fatality reported since 1987. This report summarizes the investigation of this case by county, state and federal public health officials in Arizona and Colorado. In an editorial note, the pathogenesis of plague is described, with details as to the recommended course of action when a case is diagnosed.
KW - case reports
KW - diagnosis
KW - disease vectors
KW - drug therapy
KW - epidemiology
KW - human diseases
KW - plague
KW - pneumonia
KW - respiratory diseases
KW - Arizona
KW - Colorado
KW - USA
KW - rodents
KW - Sciuridae
KW - Siphonaptera
KW - Tamias
KW - yersinia pestis
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - rodents
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Sciuridae
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Great Plains States of USA
KW - bacterium
KW - chemotherapy
KW - lung diseases
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiologic observations on porcine cysticercosis in a rural community of Michoacan State, Mexico.
AU - Sarti-G., E.
AU - Schantz, P. M.
AU - Aguilera, J.
AU - Lopez, A.
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 1992///
VL - 41
IS - 3-4
SP - 195
EP - 201
SN - 0304-4017
AD - Sarti-G., E.: P.M. Schantz, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19920878344. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Veterinary Science; Helminthology; Pig Science; Veterinary Science
N2 - The prevalence of and risk factors for Taenia solium infection (cysticercosis) in pigs were studied in a rural community in Michoacan State, Mexico. Visual inspection of the tongues of 216 pigs revealed cysticerci in 14 (6.5%). The prevalence was slightly higher in male (10 of 105) than female pigs (4 of 110) and increased with age. The most important risk factors for infection in pigs were access to human faeces at a public washing area, the presence of an indoor latrine and indiscriminate disposal of human faeces around the pig owner's household. Effective and long-lasting control of the transmission of T. solium from humans to pigs must include measures to deny pigs access to human faeces, a change which is likely to be resisted because of the traditional and functional aspects of established pig-rearing practices.
KW - Developmental stages
KW - epidemiology
KW - helminths
KW - Livestock
KW - metacestodes
KW - parasites
KW - Mexico
KW - North America
KW - Artiodactyla
KW - Cestoda
KW - pigs
KW - Suidae
KW - Taenia solium
KW - Taeniidae
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Platyhelminthes
KW - invertebrates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Taenia
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - growth phase
KW - hogs
KW - parasitic worms
KW - pork tapeworm
KW - Prevalence
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920878344&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Knowledge and beliefs about malaria on the Pacific coastal plain of Guatemala.
AU - Ruebush, T. K., II
AU - Weller, S. C.
AU - Klein, R. E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1992///
VL - 46
IS - 4
SP - 455
EP - 459
SN - 0002-9637
AD - Ruebush, T. K., II: Division of Parasitic Diseases (F-12), National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road, NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920510284. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - Surveys of the residents of 2 counties in the Department of Escuintla on the Pacific coast of Guatemala (in 1982-85) revealed a lack of knowledge and many misconceptions about the transmission and treatment of malaria which could adversely affect malaria control measures and antimalarial therapy. Although Anopheles mosquitoes are known to play an important role in malaria transmission and become infected by biting individuals with Plasmodium infection, 75% of people interviewed believed that the mosquitoes can also acquire infections from contaminated water or by biting snakes and frogs. Furthermore, most residents believed that malaria can be acquired in other ways, such as by bathing too frequently or by drinking unboiled water. Although self treatment of malaria with oral and injectable drugs purchased at stores and pharmacies is very common, <10% of the respondents were aware of the correct curative dose of chloroquine. Chloroquine injections are preferred to tablets and believed to be approximately 3 times as potent as tablets of the same concentration. Nearly two-thirds of the interviewees believed that pregnant and lactating women with malaria should avoid the use of chloroquine because it may cause a spontaneous abortion or dry up breast milk. Similar surveys of National Malaria Service workers and village malaria workers revealed higher levels of knowledge, although the village workers had many misconceptions about malaria transmission. An educational campaign directed at correcting some of these misconceptions should result in more appropriate self-treatment of malaria and greater acceptance by residents of personal protection methods and vector control and drug treatment programmes.
KW - attitudes
KW - beliefs
KW - Control
KW - Disease transmission
KW - Disease vectors
KW - malaria
KW - parasites
KW - Questionnaires
KW - Surveys
KW - Central America
KW - Guatemala
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - man
KW - Plasmodium
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - protozoa
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Plasmodium
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Attachment of Listeria monocytogenes to chitin and resistance to biocides.
AU - McCarthy, S. A.
JO - Food Technology (Chicago)
JF - Food Technology (Chicago)
Y1 - 1992///
VL - 46
IS - 12
SP - 84
EP - 87
SN - 0015-6639
AD - McCarthy, S. A.: US Food and Drug Administration, Division of Seafood Research, PO Box 158, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 19941300135. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 1398-61-4, 7782-50-5, 7553-56-2. Subject Subsets: Human Nutrition
N2 - The effects of 3 disinfectants on both suspended L. monocytogenes cells and cells attached to chitin flakes were studied. Results indicated that at recommended concn iodine and chlorine were less effective than a quarternary ammonium compound against chitin-attached cells. The results confirmed the observations of other workers that attached cells are more resistant than suspended cells and that older cultures are more resistant than younger cultures. The significance of the findings to seafood processing plants is discussed.
KW - biodeterioration
KW - chitin
KW - chlorine
KW - control
KW - disinfectants
KW - iodine
KW - pathogens
KW - processing
KW - quaternary ammonium compounds
KW - seafoods
KW - survival
KW - bacteria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - alkylammonium compounds
KW - ammonium quaternary compounds
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Pesticides and Drugs (General) (HH400)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941300135&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A cluster of Coxiella burnetii infections associated with exposure to vaccinated goats and their unpasteurized dairy products.
AU - Fishbein, D. B.
AU - Raoult, D.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1992///
VL - 47
IS - 1
SP - 35
EP - 40
SN - 0002-9637
AD - Fishbein, D. B.: Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 1600 Clifton Rd, Atlanta, GA 30333, USA.
N1 - Accession Number: 19932279024. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - An outbreak of Q fever occurred among patients and staff of a psychiatric institution in southern France. Some of the patients and staff left the institution daily to work on a farm where goats were raised for raw milk and cheese production. The goats had all been vaccinated annually with a commercial vaccine containing phase II C. burnetii antigen. A serological survey revealed that 40 (66%) of the 61 patients and staff had elevated titres to C. burnetii. Seropositive persons were more likely to report an acute illness, fever, weakness, arthralgia, and headaches in the preceding year than were seronegative persons. Seropositivity rates were significantly higher among persons who worked on the farm and consumed unpasteurized milk products (69% [22 of 32]), those who only had worked on the farm (75% [9 of 12]), compared with those who had not worked with the goats or consumed unpasteurized milk products (0 of 5). Despite vaccination against Q fever, no antibodies to C. burnetii were detectable in 17 (59%) of 29 goats. All 12 seropositive goats had antibodies to both phase I and phase II antigens, indicating that they were naturally infected, and 2 of 3 goats examined were shedding C. burnetii in their milk. Vaccination of this herd did not prevent the outbreak and might have increased shedding of C. burnetii in the dairy products.
KW - Bacterial diseases
KW - Disease transmission
KW - goat diseases
KW - goat milk
KW - Immune response
KW - Q fever
KW - Vaccination
KW - zoonoses
KW - France
KW - Coxiella burnetii
KW - goats
KW - Man
KW - Coxiella
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Capra
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - abattoir fever
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Balkan grippe
KW - Derrick-Burnet disease
KW - immunity reactions
KW - immunological reactions
KW - Nine Mile fever
KW - pneumorickettsiosis
KW - quadrilateral fever
KW - query fever
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacteriophage typing of Listeria monocytogenes cultures isolated from seafoods.
AU - Estela, L. A.
AU - Sofos, J. N.
AU - Flores, B. B.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1992///
VL - 55
IS - 1
SP - 13
EP - 17
SN - 0362-028X
AD - Estela, L. A.: Food and Drug Administration, Denver District Laboratory, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19921376402. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - L. monocytogenes cultures isolated from various seafoods were subjected to phage typing procedures utilizing the French International set of L. monocytogenes bacteriophages. These cultures were also subjected to the activity of newly isolated North American phages to L. monocytogenes. There were 147 serotype 1/2 and 80 serotype 4b L. monocytogenes cultures isolated from 16 varieties of marine products included in this study. L. monocytogenes was most frequently isolated from crab meat, salmon and shrimp. Bacteriophages to serotype 1/2 isolates most frequently observed as single patterns were 575, 1967, 2685 and 19. Serotype 4b phages observed most frequently were 1317, 2426 and 52 as single phage patterns and 52/340/110/108/2671/2425/2389 and the new North American phages 90861/910716/93253/90666 as one complete spectrum. The prevalence of L. monocytogenes and their respective phage spectra observed in the 16 varieties of seafoods studied is discussed.
KW - bacteriophages
KW - biodeterioration
KW - Crab meat
KW - Fish
KW - identification
KW - pathogens
KW - Seafoods
KW - Shrimps
KW - Bacteria
KW - Listeria monocytogenes
KW - Salmon
KW - viruses
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Biodeterioration (SS300)
KW - Aquatic Biology and Ecology (MM300)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921376402&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of five selective enrichment broths and two selective agars for recovery of Vibrio vulnificus from oysters.
AU - Sloan, E. M.
AU - Hagen, C. J.
AU - Lancette, G. A.
AU - Peeler, J. T.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1992///
VL - 55
IS - 5
SP - 356
EP - 359
SN - 0362-028X
AD - Sloan, E. M.: Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19931377841. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition
N2 - The Bacteriological Analytical Manual (6th ed) specifies use of glucose-salt-teepol (GST) broth for detection of V. vulnificus and other halophilic vibrios in seafood. Since teepol is no longer commercially available enrichment broths were compared for their ability to recover V. vulnificus. Ten samples of seeded oysters were analysed using a 3-tube MPN and enriched in each of 5 broths in duplicate. Broth cultures were then streaked onto cellobiose-polymyxin B-sucrose (SDS) agar plates. Av. (± standard error) recovery (log MPN/g) from each broth was as follows: alkaline-peptone-water (APW), 4.16 ±0.20; marine (MRN) broth, 3.63 ± 0.16; Horie's broth, 2.88 ± 0.17; Monsur's broth, 2.43 ± 0.16; and GST broth, 1.28 ± 0.28. APW and MRN broths yielded significantly (P < 0.05) higher recovery than other broths by the Kruskal-Wallis nonparametric rank test. V. vulnificus was isolated with higher frequency from CPC (81%) as compared with SDS (61%) agar plates. Background growth was minimal on CPC agar, facilitating selection of V. vulnificus colonies. Based on these results, APW enrichment broth and CPC isolation agar were more efficient for recovery of V. vulnificus from oysters than other broth and agar combinations.
KW - biodeterioration
KW - detection
KW - Oysters
KW - pathogens
KW - Seafoods
KW - Shellfish
KW - Techniques
KW - Bacteria
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - prokaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Aquatic Biology and Ecology (MM300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of two enzyme immunoassays for recovery of Salmonella spp. from four low-moisture foods.
AU - June, G. A.
AU - Sherrod, P. S.
AU - Andrews, W. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1992///
VL - 55
IS - 8
SP - 601
EP - 604
SN - 0362-028X
AD - June, G. A.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19920455096. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Dairy Science
N2 - Two enzyme immunoassays (Salmonella-Tek™ and Report™) were compared with the standard culture method of the AOAC and the FDA's Bacteriological Analytical Manual (BAM) for the recovery of Salmonella spp. from 4 low-moisture foods (dried skim milk, black pepper, soya flour and dried active yeast). Two protocols were used to compare the effectiveness of the 2 immunoassays: 1. foods were contaminated in the dry state; or 2. serial 10-fold dilutions of Salmonella spp. were inoculated into the post-enrichments after incubation. Of 300 25-g test portions inoculated in the dry state, 199 gave confirmed positive reactions with the Salmonella-Tek assay, 193 with the Report assay and 206 with the AOAC/BAM method. There were 7 false-negative reactions with Salmonella-Tek and 13 false negatives with the Report, a false negative being defined as one that was negative by the enzyme immunoassay but was confirmed positive by the AOAC/BAM culture method. When the post-enrichments were inoculated after incubation, a lower number of cells gave a positive assay result with the Salmonella-Tek system than with the Report system, indicating greater sensitivity.
KW - biodeterioration
KW - Black pepper
KW - Cows
KW - detection
KW - Dried foods
KW - Dried milk
KW - dried skim milk
KW - enzyme immunoassay
KW - Food poisoning
KW - Foods
KW - Immunology
KW - pathogens
KW - Skim milk
KW - Techniques
KW - Bacteria
KW - cattle
KW - Salmonella
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Dried yeast
KW - milk powder
KW - nonfat dry milk
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbial pathogens in fresh produce - the regulatory perspective.
AU - Madden, J. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1992///
VL - 55
IS - 10
SP - 821
EP - 823
SN - 0362-028X
AD - Madden, J. M.: Division of Microbiology, Center for Food Safely and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19931378036. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition; Horticultural Science; Postharvest Research
N2 - The high potential for microbial contamination of fruits and vegetables because of the wide variety of conditions to which the produce is exposed during growth, harvest and distribution is discussed. Heat treatment may also destroy the protective barriers (peels, husks, rinds) of fruits and vegetables, permitting the entry of microbial pathogens into the produce and providing them access to nutrients essential for their growth and proliferation. Proper refrigeration, storage and shipping conditions as well as removal of soil from fresh produce by washing with chlorinated water are recommended to prevent contamination. Examples of outbreaks of illness associated with the consumption of fresh fruit and vegetables in the USA are discussed including salmonellosis from melons, and shigellosis from lettuces. The need for vigilance regarding the possible contamination of produce by Vibrio cholerae is emphasized.
KW - biodeterioration
KW - contamination
KW - Foodborne diseases
KW - Fruit
KW - Fruits
KW - Health hazards
KW - heat treatment
KW - pathogens
KW - storage
KW - Vegetables
KW - USA
KW - Bacteria
KW - Salmonella
KW - Shigella
KW - Vibrio cholerae
KW - prokaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - heat processing
KW - United States of America
KW - vegetable crops
KW - Other Control Measures (HH700)
KW - Biodeterioration (SS300)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931378036&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermotolerance of heat-shocked Listeria monocytogenes in milk exposed to high-temperature, short-time pasteurization.
AU - Bunning, V. K.
AU - Crawford, R. G.
AU - Tierney, J. T.
AU - Peeler, J. T.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1992///
VL - 58
IS - 6
SP - 2096
EP - 2098
SN - 0099-2240
AD - Bunning, V. K.: Division of Microbiology, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19931377448. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The effect of prior heat shock (48°C for 15 min) on the thermotolerance of L. monocytogenes at the min. high-temp., short-time (71.7°C for 15 s) parameters required by the Pasteurized Milk Ordinance was examined. The mean D71.7°C value for heat-shocked L. monocytogenes was 4.6 ± 0.5 s (control D = 3.0 ± 1.0 s); the ratio of D to control D was 1.5. The increased thermotolerance of heat-shocked Listeria cells was not significant and appeared unlikely to have practical implications, in terms of risk assessment, for the safety of pasteurized milk.
KW - biodeterioration
KW - Cows
KW - Milk
KW - pasteurization
KW - pathogens
KW - survival
KW - Temperature
KW - temperature resistance
KW - cattle
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - pasteurizing
KW - Environmental Tolerance of Plants (FF900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Milk and Dairy Produce (QQ010)
KW - Microbiology (General) (ZZ390)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931377448&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Virulence characteristics of clinical and environmental isolates of Vibrio vulnificus.
AU - Stelma, G. N., Jr.
AU - Reyes, A. L.
AU - Peeler, J. T.
AU - Johnson, C. H.
AU - Spaulding, P. L.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1992///
VL - 58
IS - 9
SP - 2776
EP - 2782
SN - 0099-2240
AD - Stelma, G. N., Jr.: Division of Microbiology, US Food and Drug Administration, 200 C St. S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19931377764. Publication Type: Journal Article. Language: English. Number of References: 30 ref.
N2 - Twenty-four randomly selected clinical and environmental V. vulnificus isolates were tested for virulence in iron-overloaded mice (250 mg of iron dextran/kg body wt). The log10 50% lethal doses of 17 isolates were lower by ≥ 3.5 log10 units in iron-overloaded mice than in control mice. These isolates were classified as virulent. The 50% lethal doses of these virulent isolates were also lower in mice that were immunosuppressed by treatment with cyclophosphamide (150 mg/kg). Four of the 7 isolates initially classified as avirulent were virulent in mice that were simultaneously iron overloaded and immunosuppressed. These isolates were classified as moderately virulent. The remaining 3 isolates were avirulent under all conditions. The incidence of virulent strs among clinical and environmental isolates did not differ. The virulent isolates produced high titres of haemolysin, were resistant to inactivation by serum complement, produced phenolate siderophore, and utilized transferrin-bound iron. The moderately virulent isolates differed from the virulent isolates only in their increased sensitivity to inactivation by serum complement. The avirulent isolates differed from those of the other 2 classes in their inability either to produce significant amounts of phenolate siderophore or utilize transferrin-bound iron. A modified agar plate diffusion method for transferrin-bound iron utilization was developed to differentiate the 2 classes of virulent isolates from the avirulent isolates in vitro.
KW - biodeterioration
KW - Pathogens
KW - techniques
KW - virulence
KW - Bacteria
KW - Vibrio vulnificus
KW - prokaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Biodeterioration (SS300)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931377764&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Direct extraction of bacterial plasmids from food for polymerase chain reaction amplification.
AU - Andersen, M. R.
AU - Omiecinski, C. J.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1992///
VL - 58
IS - 12
SP - 4080
EP - 4082
SN - 0099-2240
AD - Andersen, M. R.: Food and Drug Administration, Seattle District Office, P.O. Box 3012, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19931377948. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A simple and rapid technique using DNA affinity columns permitting direct extraction of bacterial plasmids from a variety of foods for polymerase chain reaction amplification is described. The procedure was used to detect virulent enteroinvasive Escherichia coli in several artificially seeded matrices, including seafoods, greens, dairy products, enrichment media and water. Polymerase inhibitors present in both foods and enrichment media were removed efficiently.
KW - biodeterioration
KW - cows
KW - detection
KW - Foods
KW - Milk products
KW - pathogens
KW - Plasmids
KW - Polymerase chain reaction
KW - Seafoods
KW - Techniques
KW - Vegetables
KW - bacteria
KW - cattle
KW - Escherichia coli
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - dairy products
KW - E. coli
KW - PCR
KW - vegetable crops
KW - Aquatic Produce (QQ060)
KW - Milk and Dairy Produce (QQ010)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931377948&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
AU - Dooley, K. L.
AU - Tungeln, L. S. von
AU - Bucci, T.
AU - Fu, P. P.
AU - Kadlubar, F. F.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 1992///
VL - 62
IS - 3
SP - 205
EP - 209
SN - 0304-3835
AD - Dooley, K. L.: National Center for Toxicological Research (HFT-100), Jefferson, AR 72079, USA.
N1 - Accession Number: 19931465153. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The tumourigenic activities of 4 representative heterocyclic amine food pyrolysates, 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1), 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQX) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were assessed in the neonatal male B6C3F1 mouse and were compared with that of the potent human carcinogen 4-amino-biphenyl (4-ABP). These aromatic amines were administered by intraperitoneal injection at 2 dose levels on days 1, 8 and 15 after birth, and the incidence of tumours was examined at 8 and 12 months. Glu-P-1, IQ, PhIP, MeIQX and 4-ABP each induced a significant incidence of hepatic adenomas, compared with the solvent-treated (DMSO) control. Hepatocellular carcinomas were also observed with 4-ABP, SO and MeIQX. Overall tumourigenicity was in the order: 4-ABP > Glu-P-I > IQ and PhIP > MeIQX > DMSO. In the neonatal B6C3F1 mouse, these heterocyclic aromatic amines showed potent tumourigenicity after 8 and 12 months at total doses 5- to 10 000-fold less than those used in standard chronic bioassays.
KW - carcinogenesis
KW - Foods
KW - heterocyclic nitrogen compounds
KW - newborn animals
KW - products
KW - pyrolysis
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Food Science and Food Products (Human) (QQ000)
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931465153&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New record of the blowfly, Chrysomya megacephala (Fabr.), from Ecuador (Diptera: Calliphoridae).
AU - Olsen, A. R.
AU - Angold, S. C.
AU - Gross, D. F.
AU - Sidebottom, T. H.
JO - Pan-Pacific Entomologist
JF - Pan-Pacific Entomologist
Y1 - 1992///
VL - 68
IS - 4
SP - 280
EP - 281
SN - 0031-0603
AD - Olsen, A. R.: US Food and Drug Administration, 1521 W. Pico Blvd., Los Angeles, CA 90015-2483, USA.
N1 - Accession Number: 19950502688. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology
N2 - Chrysomya megacephala was found in frozen fillets of dolphinfish (mahi mahi) imported to California, USA, from Ecuador.
KW - distribution
KW - fish
KW - geographical distribution
KW - introduced species
KW - new geographic records
KW - California
KW - Ecuador
KW - USA
KW - Calliphoridae
KW - Chrysomya megacephala
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Chrysomya
KW - Calliphoridae
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - South America
KW - Threshold Countries
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - Biological Resources (Animal) (PP710)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502688&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins in foods and feeds in the United States.
AU - Wood, G. E.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1992///
VL - 70
IS - 12
SP - 3941
EP - 3949
SN - 0021-8812
AD - Wood, G. E.: Division of Contaminants Chemistry, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931456883. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Veterinary Science; Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology; Postharvest Research
N2 - This article focuses on measures being taken by the Food and Drug Administration, USA, to ensure that the food and feed supplies in the USA are relatively free from aflatoxin contamination. Activities and concerns relating to other mycotoxins (ochratoxins, zearalenone, trichothecenes, patulin and penicillic acid, cyclopiazonic acid, sterigmatocystin, Alternaria, ergot alkaloids and fumonisins) are also discussed.
KW - Aflatoxins
KW - biodeterioration
KW - contamination
KW - feeds
KW - foods
KW - Mycotoxins
KW - pathogens
KW - USA
KW - fungi
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - fungal toxins
KW - United States of America
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Precision parameters of methods of analysis required for nutrition labelling. 2. Macro elements-calcium, magnesium, phosphorus, potassium, sodium, and sulfur.
AU - Horwitz, W.
AU - Albert, R.
AU - Deutsch, M. J.
AU - Thompson, J. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 2
SP - 227
EP - 239
SN - 1060-3271
AD - Horwitz, W.: US FDA, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19941406106. Publication Type: Journal Article. Language: English. Registry Number: 7440-23-5, 7704-34-9, 7440-70-2, 7440-09-7, 7723-14-0, 7439-95-4. Subject Subsets: Human Nutrition
N2 - The precision of analysis for calcium, magnesium, phosphorus, potassium, sodium and sulfur is reviewed. The purpose is to provide a reasonable approximation of the analytical error to be expected in the analysis by different laboratories of elements that are typically present in foods in concentrations of 0.01 to 10 g/100 g. Methods of analysis are those adopted and published by the AOAC. The precision parameters among laboratories (standard deviation, relative s.d. (RSD), and repeatability (+) and reproducibility (R) values) are not characterized by any conventional distribution. The typical precision of the methods of analysis for these elements in food can be expressed solely as a logarithmic function of concentration, independent of analyte, matrix and method. Average RSDR value from each collaborative assay found in the literature was used as the numerator in a ratio containing, as the denominator, the value calculated from the logarithmic function: RSDR (%) = 2(1-0.5logC) where C is the concentration as a decimal fraction. If this ratio, designated as HORRAT, is above 2, the method is probably unacceptable with respect to precision. About 20% of the 465 interlaboratory data sets studied showed an RSDR exceeding the acceptable limit, with an overall mean HORRAT of 1.2 at C ranging from about 20 × 10-6 to about 10-1. The variability, although high, may be acceptable for the purpose of nutrition labelling.
KW - analytical methods
KW - calcium
KW - estimation
KW - foods
KW - labelling
KW - magnesium
KW - nutrition
KW - phosphorus
KW - potassium
KW - reviews
KW - sodium
KW - sulfur
KW - analytical techniques
KW - elemental sulphur
KW - labeling
KW - labels
KW - sulphur
KW - Chemistry (ZZ600) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extraction of light filth from fish paste and sauce (bagoong) not containing spice: collaborative study.
AU - Glaze, L. E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 2
SP - 263
EP - 265
SN - 1060-3271
AD - Glaze, L. E.: US Food and Drug Administration, Division of Microbiology, Washington, DC 20204, USA.
N1 - Accession Number: 19941406108. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Fermented fish pastes and sauces comprise a large proportion of ethnic food products imported into the USA. A collaborative study was made to validate a new method for extraction of light filth from fish paste and sauce (Bagoong) not containing spice. A 225 g test portion was digested by boiling in a mixture of acid and emulsifying agents. Light filth was isolated by wet sieving on a No. 230 plain weave sieve with Tegitol, a deaeration boil in 40% isopropanol, and flotation with mineral oil and 40% isopropanol in a Wildman trap flask. 3 spiking levels were used in the study for rat hairs and insect fragments; 1 level was used for whole or equivalent insects. For rat hairs, recoveries at the low, medium and high levels were on average 77, 94 and 76%, respectively. Recoveries of insect fragments for these levels were on average 92, 88 and 93%; recoveries of whole or equivalent insects were on average 85, 70 and 80%. The method was adopted first action the AOAC International for the extraction of light filth from fish paste and sauce (Bagoong) not containing spice.
KW - adulterants
KW - analytical methods
KW - fish pastes
KW - foods
KW - analytical techniques
KW - Chemistry (ZZ600) (Discontinued March 2000)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406108&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extraction of light filth from dried bean curd: collaborative study.
AU - Nakashima, M. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 2
SP - 266
EP - 268
SN - 1060-3271
AD - Nakashima, M. J.: US Food and Drug Administration, Division of Microbiology, Washington, DC 20204, USA.
N1 - Accession Number: 19941406110. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Soyabeans
N2 - Results are reported for a collaborative study of a method for the extraction of light filth from dried bean curd. A 100 g test portion was dispersed in a 5.7% HCl solution. Residue from the No. 230 sieve was defatted in isopropanol, and the sieved residue was transferred to a Wildman trap flask. Light filth was isolated from 40% isopropanol by using Na4EDTA and mineral oil-heptane (70 + 30). Average recoveries by 6 collaborators for 3 spike levels of rat hairs (5, 10 and 15) were 85, 81 and 70%, respectively; for insect fragments (5, 15 and 30), recoveries were 72, 83 and 72%. The method was adopted by the AOAC International as first action.
KW - adulterants
KW - analytical methods
KW - removal
KW - soyabean products
KW - techniques
KW - tofu
KW - analytical techniques
KW - bean curd
KW - soyabean curd
KW - soybean curd
KW - soybean products
KW - Chemistry (ZZ600) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941406110&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of cyclopiazonic acid in corn and peanuts.
AU - Urano, T.
AU - Trucksess, M. W.
AU - Matusik, J.
AU - Dorner, J. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 2
SP - 319
EP - 322
SN - 1060-3271
AD - Urano, T.: U.S. Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19921212115. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 18172-33-3. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Postharvest Research; Maize
N2 - A liquid chromatographic (LC) method is described for the determination of cyclopiazonic acid (CPA) in maize and groundnuts. CPA was extracted from the test portion with methanol-2% NaHCO3 solution (7 + 3); the extract was defatted with hexane and then acidified. CPA was partitioned into chloroform and applied to a Sep-Pak silica cartridge. CPA was eluted with chloroform-methanol (3 + 1), the solvent was evaporated and the residue was dissolved in methanol-water (60 + 40). CPA was quantitated by reversed-phase LC with a linear gradient of 0-4 mM ZnSO4 in methanol-water (85 + 15) and UV measurement at 279 nm. Recoveries of CPA from maize spiked over the range of 50-500 ng/g and groundnuts spiked over the range of 100-500 ng/g were 72-84% and 74-80%, respectively. The limits of quantitation for CPA in maize and groundnuts were approx. 50 and 100 ng/g, respectively. CPA (820 ng/g) was found in maize naturally contaminated with aflatoxin B1 and CPA identity was confirmed by tandem MS.
KW - biodeterioration
KW - contamination
KW - Cyclopiazonic acid
KW - determination
KW - estimation
KW - groundnuts
KW - liquid chromatography
KW - maize
KW - Mycotoxins
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - corn
KW - fungal toxins
KW - peanuts
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921212115&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunologic characterization of jird lymphocyte responsiveness to Brugia pahangi ribosomal protein S13.
AU - Ellenberger, D. L.
AU - Lammie, P. J.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1992///
VL - 75
IS - 3
SP - 293
EP - 302
SN - 0014-4894
AD - Ellenberger, D. L.: Parasitic Diseases Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19920801478. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Helminthology
N2 - Ribosomal protein S13 of B. pahangi is recognized by B and T cells from parasite-infected animals. To identify helper T cell sites on the protein, 15 overlapping synthetic peptides spanning the entire molecule (Bp17.4) were tested for their ability to stimulate lymph node and spleen cells of peptide-immunized and recombinant antigen-immunized jirds. Lymph node cells from animals immunized with peptides 6, 8, 9, 13 and 14, corresponding to Bp17.4 amino acids (AA) 50-70, 70-90, 80-100, 120-140, and 130-150, respectively, showed strong and specific responses to the homologous peptide, while only those lymph node cells from jirds immunized with peptides 8, 9, 13 and 14 proliferated in response to Bp17.4. These results suggest the existence of at least 2 T cell epitopes. Lymph node cells from infected jirds also responded to these peptides and to Bp17.4 (80 000 cpm). In contrast to the lymph node cells, spleen cells from microfilaria-positive animals failed to mount significant responses to any of the peptides or to Bp17.4. Splenic T cell responsiveness was restored upon removal of nylon wool-adherent cells, suggesting active regulation of Bp17.4 reactivity. In liquid-phase competitive inhibition immunoassays, peptides 1 (AA 1-30) and 6 (50-70) blocked antibody binding and, therefore, these regions contain conformational antibody-binding sites.
KW - Epitopes
KW - Experimental infections
KW - helminths
KW - Human diseases
KW - immune response
KW - Laboratory animals
KW - parasites
KW - Proteins
KW - T lymphocytes
KW - Brugia pahangi
KW - Meriones unguiculatus
KW - Muridae
KW - Nematoda
KW - Onchocercidae
KW - Rodents
KW - Brugia
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Meriones
KW - Gerbillinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - antigenic determinants
KW - immunity reactions
KW - immunological reactions
KW - nematodes
KW - parasitic worms
KW - Ribosomal protein
KW - Secernentea
KW - Spirurida
KW - T cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19920801478&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of gentian violet in poultry feed.
AU - Roybal, J. E.
AU - Munns, R. K.
AU - Holland, D. C.
AU - Burkepile, R. G.
AU - Hurlbut, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 3
SP - 433
EP - 437
SN - 1060-3271
AD - Roybal, J. E.: U.S. Food and Drug Administration, Animal Drug Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19922270518. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 548-62-9. Subject Subsets: Animal Nutrition; Veterinary Science; Veterinary Science; Poultry; Helminthology; Medical & Veterinary Mycology
N2 - A liquid chromatographic (LC) method is presented for the determination of gentian violet (GV) in poultry feed (turkey/chicken) at the therapeutic feeding level of 4-8 ppm. GV is extracted from feed with acidified methanol, an aliquot of the supernatant is diluted with mobile phase, and the solution is filtered. LC analysis is performed by isocratic elution with a buffered mobile phase on an Altech CN (cyano) column with amperometric electrochemical detection (ED) at +1.000 V or detection in the visible absorbance mode at 588 nm. The overall average recovery of GV from chicken feed spiked at 2.5, 5, and 10 ppm was 103% (standard deviation = 6.6; coefficient of variation = 6.4%) by LC/ED analysis. Results for recovery of GV from chicken and turkey feeds, fortified with 1% GV premix at feeding levels of 4 and 8 ppm, are presented and discussed. Results for the 2 detection techniques are compared.
KW - Anthelmintics
KW - Antifungal agents
KW - Antiparasitic agents
KW - assays
KW - detection
KW - feeds
KW - gentian violet
KW - helminths
KW - Liquid chromatography
KW - medicated feeds
KW - parasites
KW - crystal violet
KW - feeding stuffs
KW - fungistats
KW - methylrosanilinium
KW - parasitic worms
KW - parasiticides
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Feed Additives (RR130)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid solvent-efficient method for liquid chromatographic determination of ochratoxin A in corn, barley, and kidney: collaborative study.
AU - Nesheim, S.
AU - Stack, M. E.
AU - Trucksess, M. W.
AU - Eppley, R. M.
AU - Krogh, P.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 3
SP - 481
EP - 487
SN - 1060-3271
AD - Nesheim, S.: U.S. Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19921212237. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research; Human Nutrition; Wheat, Barley & Triticale Abstracts; Maize
N2 - A joint interlaboratory study of a rapid, solvent-efficient liquid chromatographic method for determination of ochratoxin A (OTA) in barley, maize and pork kidney tissue was conducted by AOAC, the International Union of Pure and Applied Chemistry, and the Nordic Committee on Food Analysis in 16 laboratories in Europe, Canada and the USA. OTA was added to barley and maize at 10, 20 and 50 ng/g and to kidney at 5, 10 and 20 ng/g. Duplicate test portions were prepared at 20 ng/g for maize and barley and 10 ng/g for kidney. Mean recoveries of OTA ranged from 53 to 97%. Within-laboratory relative standard deviations were 7.9, 20.1 and 15.7% for barley, maize and kidney tissue, respectively. Between-laboratories relative standard deviations were 20.7-31.7% for all concn of OTA in barley and maize and 68.0, 41.8 and 32.7% for OTA concn of 5, 10 and 20 ng/g, respectively, in kidney. OTA identity was confirmed by methyl ester derivatization followed by liquid chromatography. The method was adopted first action by AOAC as quantitative at the levels tested for OTA determination in maize and barley.
KW - barley
KW - biodeterioration
KW - contamination
KW - detection
KW - determination
KW - estimation
KW - kidneys
KW - kidneys as food
KW - liquid chromatography
KW - maize
KW - Mycotoxins
KW - Ochratoxins
KW - techniques
KW - Hordeum
KW - Hordeum vulgare
KW - Zea mays
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Hordeum
KW - Zea
KW - corn
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of thiamine, riboflavin, and pyridoxine in infant formula.
AU - Chase, G. W., Jr.
AU - Landen, W. O., Jr.
AU - Eitenmiller, R. R.
AU - Soliman, A. G. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 3
SP - 561
EP - 565
SN - 1060-3271
AD - Chase, G. W., Jr.: US Food and Drug Administration, 60 8th St. NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 19940402980. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 65-23-6, 83-88-5, 59-43-8. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - An ion-pairing reversed-phase liquid chromatographic method developed for multi-vitamin supplements and premixes was applied to the simultaneous determination of thiamin, riboflavin and pyridoxine in perchloric acid extracts of milk- and soya-based infant formulae. The method uses m-hydroxybenzoic acid as internal standard, and a mobile phase consisting of water, acetonitrile, hexanesulphonic acid sodium salt and ammonium hydroxide solution, adjusted to pH 3.6 with phosphoric acid. The column is a 15 cm × 3.9 mm Nova Pak C18. Limits of detection were 0.15 µg/ml for thiamin and 0.09 µg/ml for riboflavin by UV detection at 254 nm, and 0.010 µg/ml for pyridoxine by fluorescence detection. Mean percentage recoveries based on triplicate determinations were 102±1.8, 102±3.3 and 101±3.1 for thiamin, riboflavin and pyridoxine respectively. The results compared favourably with the AOAC methods for these 3 vitamins.
KW - analytical methods
KW - chromatography
KW - cows
KW - determination
KW - infant formulae
KW - liquid chromatography
KW - pyridoxine
KW - riboflavin
KW - soyabean products
KW - techniques
KW - thiamin
KW - vitamins
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - aneurin
KW - infant formula
KW - infant formulas
KW - soybean products
KW - thiamine
KW - vitamin B1
KW - vitamin B2
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of fatty and nonfat foods for chlorophenoxy alkyl acids and pentachlorophenol.
AU - Hopper, M. L.
AU - McMahon, B.
AU - Griffitt, K. R.
AU - Cline, K.
AU - Fleming-Jones, M. E.
AU - Kendall, D. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 4
SP - 707
EP - 713
SN - 1060-3271
AD - Hopper, M. L.: US Food and Drug Administration, Total Diet Research Center, 1009 Cherry St, Kansas City, MO 64106, USA.
N1 - Accession Number: 19941411656. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 87-86-5. Subject Subsets: Human Nutrition
N2 - A multiresidue method was developed to analyze low-level residues of chlorophenoxy alkyl acids and pentachlorophenol (PCP) in fatty and nonfat foods. The acidified sample was extracted, cleaned up using gel permeation chromatography, methylated by ion-pair alkylation with tetrabutyl-ammonium hydroxide and methyl iodide, cleaned up by using Florisil, and determined by gas chromatography using electron capture and/or electrolytic conductivity detectors. recoveries ranged from 53-75% for 2,4-D at 200 ppb, 61 to 93% for 2,4,5-T at 80 ppb, and 76 to 84% for PCP at 20 ppb fortified in a variety of food items. Also, 31 other herbicides were evaluated through this procedure.
KW - analytical methods
KW - food contamination
KW - foods
KW - pentachlorophenol
KW - pesticide residues
KW - analytical techniques
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941411656&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of ivermectin in bovine milk: interlaboratory study.
AU - Kijak, P. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 4
SP - 747
EP - 750
SN - 1060-3271
AD - Kijak, P. J.: U. S. Food and Drug Administration, Centre for Veterinary Medicine, Building 328-A, BARC-East, Beltsville, MDS 20705, USA.
N1 - Accession Number: 19932291210. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 70288-86-7. Subject Subsets: Veterinary Science; Veterinary Science; Helminthology; Animal Nutrition; Dairy Science
N2 - A laboratory trial was completed for an analytical method that can measure the marker residue of ivermectin, 22,23-dihydroavermectin F1a, in bovine milk at 1 ng/ml. Currently, ivermectin is not approved for use in lactating dairy cows. In this method, the ivermectin residues are isolated from the milk matrix by a series of liquid-liquid extractions. A fluorescent derivative of the marker compound is prepared and then measured by liquid chromatography with fluorescence detection. The interlaboratory study was successfully completed using dosed milk and milk fortified with marker residue at 1, 2 and 4 ng/ml. The average recoveries by the 3 participating laboratories were 87, 59 and 95% at 1 ng/ml; 90, 61 and 96% at 2 ng/ml; and 90, 73 and 99% at 4 ng/ml. The concentrations of the marker residue in the dosed milk were 4.3, 3.7 and 4.7 ng/ml; coefficients of variation were 4.0, 24.8 and 5.9% respectively.
KW - anthelmintics
KW - assays
KW - chromatography
KW - cows
KW - dairy cattle
KW - drug residues
KW - drugs
KW - estimation
KW - helminths
KW - ivermectin
KW - liquid chromatography
KW - milk
KW - milk hygiene
KW - parasites
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - medicines
KW - parasitic worms
KW - pharmaceuticals
KW - Pesticides and Drugs (General) (HH400)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Method I. Liquid chromatography/fluorescence determination of ivermectin in animal tissue and plasma.
A2 - Markus, J.
A2 - Sherma, J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 4
SP - 757
EP - 767
SN - 1060-3271
AD - US Food and Drug Administration, Department of Health and Human Services, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19950800389. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Registry Number: 70288-86-7. Subject Subsets: Veterinary Science; Helminthology
N2 - This method was submitted by the applicant, Merck Sharp & Dohme Research Laboratories, Merck & Co., Inc., of Rahway, NJ, in conjunction with the requirements for approval of animal drug applications for use in cattle, sheep and pigs.
KW - animal tissues
KW - anthelmintics
KW - detection
KW - drug residues
KW - helminths
KW - ivermectin
KW - parasites
KW - plasma
KW - techniques
KW - USA
KW - cattle
KW - pigs
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - hogs
KW - parasitic worms
KW - swine
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Method II. Liquid chromatography/fluorescence confirmatory assay of ivermectin in cattle, sheep, and swine liver tissues.
A2 - Markus, J.
A2 - Sherma, J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1992///
VL - 75
IS - 4
SP - 767
EP - 771
SN - 1060-3271
AD - US Food and Drug Administration, Department of Health and Human Services, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19950800390. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Registry Number: 70288-86-7. Subject Subsets: Veterinary Science; Helminthology; Pig Science
N2 - This method was submitted by the applicant, Merck Sharp & Dohme Research Laboratories, Merck & Co., Inc., of Rahway, NJ, in conjunction with the requirements for approval of animal drug applications for use in cattle, sheep and pigs.
KW - anthelmintics
KW - detection
KW - drug residues
KW - helminths
KW - ivermectin
KW - liver
KW - parasites
KW - techniques
KW - USA
KW - cattle
KW - pigs
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - hogs
KW - parasitic worms
KW - swine
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Do time trends in food supply levels of macronutrients reflect survey estimates or macronutrient intake?
AU - Crane, N. T.
AU - Lewis, C. J.
AU - Yetley, E. A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992///
VL - 82
IS - 6
SP - 862
EP - 866
SN - 0090-0036
AD - Crane, N. T.: MS, MPH, Food and Drug Administration, Division of Nutrition (HFF-265), 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19931464786. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - Using per capita food supply estimates and survey estimates of individual intake, the degree of correlation between trends in food supply and survey intake estimates for fat, carbohydrate, and protein was examined. The data selected for comparison included all available survey estimates of mean intake by the US population (i.e., periodic estimates from 1965 to 1988) and all available per capita food supply estimates from a comparable time period (i.e., annual estimates from 1965 to 1985). The 2 types of data generally did not reflect the same trends. Furthermore, expressing macronutrient levels as percentage of energy rather than in grams affected the trend relations. The findings indicate that caution is needed in the selection and application of available data to estimate trends in macronutrient intake by the US population and in the interpretation of these data with regard to public health research.
KW - comparisons
KW - Diet studies
KW - Food intake
KW - Food supply
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The mortality of lead smelter workers: an update.
AU - Steenland, K.
AU - Selevan, S.
AU - Landrigan, P.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992///
VL - 82
IS - 12
SP - 1641
EP - 1644
SN - 0090-0036
AD - Steenland, K.: National Institute for Occupational Safety and Health, R13, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19932020756. Publication Type: Journal Article. Language: English. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - This report updates a 1985 study (Selevan et al., American Journal of Epidemiology, 122, 673-683) on 1990 male smelter workers by adding 11 years of follow-up and 363 new deaths. "The original study had found elevated but nonsignificant risks for kidney cancer, stroke, and nonmalignant renal disease, probably attributable to lead exposure. Deaths from accidents and nonmalignant respiratory disease were significantly elevated, but probably not as a result of lead exposure. In the updated study, no new deaths from nonmalignant renal disease occurred (9 observed, standardized mortality ratio = 1.21). Three more deaths from kidney cancer were observed, yielding a standardized mortality ratio of 1.93 (9 observed, 95% CI = 0.88, 3.67), which increased for those who had worked in areas with the highest lead exposure (8 observed, standardized mortality ratio = 2.39, 95% CI = 1.03, 4.71). Cerebrovascular disease remained elevated for those with more than 20 years of exposure (26 observed, standardized mortality ratio = 1.41, 95% CI = 0.92, 2.07)." D.W. FitzSimons
KW - exposure
KW - Lead
KW - mortality
KW - occupational medicine
KW - occupations
KW - smelter workers
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - America (North)
KW - death rate
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932020756&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long-term suppression of microfilaraemia following ivermectin treatment.
AU - Eberhard, M. L.
AU - Hightower, A. W.
AU - McNeeley, D. F.
AU - Lammie, P. J.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1992///
VL - 86
IS - 3
SP - 287
EP - 288
SN - 0035-9203
AD - Eberhard, M. L.: Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Services, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930879957. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 70288-86-7. Subject Subsets: Helminthology; Tropical Diseases
N2 - In a study conducted in Haiti, it was found that high doses of ivermectin suppress microfilaraemia levels for 2 years. 30 Wuchereria bancrofti microfilaraemic volunteers between the ages of 16 and 65 years, were randomly enrolled into one of 3 treatment groups. All received a clearing dose of ivermectin (1 mg) 5 days before receiving either 6 mg/kg diethylcarbamazine citrate for 12 days (group 1), a single dose of 200 µg/kg ivermectin followed by placebo for 11 days (group 2), or 200 µg/kg ivermectin for 2 days followed by placebo for 10 days (group 3). The findings suggest that a single dose of ivermectin can reduce transmission of lymphatic filariasis for extended periods of time, thus eliminating the need for costly biannual treatment.<new para>ADDITIONAL ABSTRACT:<new para>In a study conducted in Haiti, it was found that high doses of ivermectin suppress microfilaraemia levels for 2 years. 30 Wuchereria bancrofti microfilaraemic volunteers between the ages of 16 and 65 years were randomly enrolled into one of 3 treatment groups. All received a clearing dose of ivermectin (1 mg) 5 days before receiving either 6 mg/kg diethylcarbamazine citrate for 12 days (group 1), a single dose of 200 µg/kg ivermectin followed by placebo for 11 days (group 2), or 200 µg/kg ivermectin for 2 days followed by placebo for 10 days (group 3). The findings suggest that a single dose of ivermectin can reduce transmission of lymphatic filariasis for extended periods of time, thus eliminating the need for costly biannual treatment.
KW - Anthelmintics
KW - bancroftian filariasis
KW - drug therapy
KW - Filariasis
KW - helminths
KW - Human diseases
KW - Ivermectin
KW - parasites
KW - treatment
KW - Caribbean
KW - Haiti
KW - man
KW - Onchocercidae
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Wuchereria
KW - Onchocercidae
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - chemotherapy
KW - long term effects
KW - microfilaraemia
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - West Indies
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930879957&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - South American monkeys in the development and testing of malarial vaccines - a review.
AU - Collins, W. E.
A2 - Ribeiro, C. T. D.
A2 - Momen, H.
JO - Memórias do Instituto Oswaldo Cruz
JF - Memórias do Instituto Oswaldo Cruz
Y1 - 1992///
VL - 87
IS - Suppl. III
SP - 401
EP - 406
SN - 0074-0276
AD - Collins, W. E.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950805416. Publication Type: Journal Article. Language: English. Number of References: 39 ref.
N2 - South American Aotus and Saimiri monkeys, which are susceptible to infection with human malarias, have been used to develop models for the testing of human malaria vaccines. Studies have indicated that blood-stage and sporozoite vaccines can be tested in these monkeys using appropriate strains of parasites. Models for testing Plasmodium falciparum and P. vivax vaccines are reviewed.
KW - animal models
KW - human diseases
KW - malaria
KW - vaccine development
KW - Aotus
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium falciparum
KW - Plasmodium vivax
KW - Saimiri
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Protozoa
KW - invertebrates
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805416&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Focus group sessions on formats of nutrition labels.
AU - Lewis, C. J.
AU - Yetley, E. A.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 1
SP - 62
EP - 66
SN - 0002-8223
AD - Lewis, C. J.: Experimental Clinical Research Section, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931456573. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - Four consumer focus group sessions, with a total of 40 participants, gathered information on the utility and appropriateness of selected components of nutrition label formats. The formats reviewed were bar graphs, pie charts, numeric listings and adjectival descriptors such as high and low. Participants were asked to compare food labels using various format types and to discuss the utility and interpretability of the formats. The outcomes suggested that these consumers did not find pie charts useful. They considered bar graphs confusing or unnecessary when numeric values were provided. Participants expressed concern that adjectival descriptors could be misleading. The numeric listing format they considered the most useful consisted of 2 columns of numbers: 1 listing the amount of food components in a serving of the food, and a second listing the percentage of the label reference value (e.g., the USA recommended daily allowance) or the quality established as the label reference value. Participants repeatedly stressed their interest in a simple label. The results form a component of the Food and Drug Administration's efforts to evaluate nutrition label formats and will be used in conjunction with ongoing experimental and quantitative research studies.
KW - Foods
KW - labelling
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931456573&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatic toxicity of unmodified and time-release preparations of niacin.
AU - Rader, J. I.
AU - Calvert, R. J.
AU - Hathcock, J. N.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1992///
VL - 92
IS - 1
SP - 77
EP - 81
SN - 0002-9343
AD - Rader, J. I.: Division of Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19921453391. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 59-67-6. Subject Subsets: Human Nutrition
N2 - Niacin (nicotinic acid) is used frequently in the treatment of hypercholesterolaemia. It is available in both unmodified and time-release preparations. The latter were developed in attempts to minimize the skin-flushing reaction that affects virtually all users, and may limit acceptance. Adverse effects on the liver from both unmodified and time-release preparations have been recognized for many years. The literature on the hepatic toxicity of both types of niacin preparations was reviewed. Adverse reactions in 6 patients resulted from the exclusive use of unmodified niacin and in 2 patients from the exclusive use of time-release preparations. In 10 additional patients, adverse reactions developed after an abrupt change from unmodified to time-release preparations. Many of these patients were ingesting time-release niacin at doses well above the usual therapeutic doses currently recommended. Signs of liver toxicity developed in less than 7 days in 4 of these 10 patients. In doses that achieve equivalent reductions in serum lipids, hepatic toxicity occurred more frequently with time-release preparations than with unmodified preparations. An awareness of toxicity associated with ingestion of high doses of time-release niacin preparations is important because of their widespread availability and the potential for self-prescribed, unmonitored use.
KW - liver
KW - Nicotinic acid
KW - reviews
KW - toxicity
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - niacin
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19921453391&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An analysis of FDA passive surveillance reports of seizures associated with consumption of aspartame.
AU - Tollefson, L.
AU - Barnard, R. J.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 5
SP - 598
EP - 601
SN - 0002-8223
AD - Tollefson, L.: Clinical Nutrition Assessment Section of the Center for Food Safety and Applied Nutrition at the US Food and Drug Administration in Washington, DC 20204, USA.
N1 - Accession Number: 19931461307. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 22839-47-0. Subject Subsets: Human Nutrition
N2 - Aspartame was approved by the US Food and Drug Administration (FDA) in July 1981. FDA monitors complaints from consumers and health professionals through the Adverse Reaction Monitoring System, a passive surveillance programme and have received 251 reports of seizures linked to ingestion of aspartame by consumers. In most cases, information obtained from the complainants' medical records as well as data on consumption patterns, temporal relationships and challenge tests did not support the claim that the occurences of the seizures were linked to consumption of aspartame.
KW - adverse effects
KW - Aspartame
KW - Foods
KW - intake
KW - monitoring
KW - adverse reactions
KW - surveillance systems
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931461307&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrient intakes and body weights of persons consuming high and moderate levels of added sugars.
AU - Lewis, C. J.
AU - Park, Y. K.
AU - Dexter, P. B.
AU - Yetley, E. A.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 6
SP - 708
EP - 713
SN - 0002-8223
AD - Lewis, C. J.: Clinical Nutrition Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931464758. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Sugar Industry
N2 - A nationally representative sample of persons aged 4 years and older were classified as high or moderate consumers of added sugars (ie, sugars added to foods by processors or consumers). Intake of added sugars was estimated on the basis of g/kg body weight and on the basis of percent of dietary energy from added sugars (%E). Regardless of the intake measure used, high consumers of added sugars had a significantly lower percentage of dietary energy from fat than did moderate consumers of added sugars. Persons defined by the %E measure as high consumers of added sugars took in lower percentages of the recommended dietary allowances (RDAs) for 11 vitamins and minerals; these high consumers had body weights similar to those of their moderate counterparts. Persons defined as high consumers by the g/kg measure consumed greater percentages of the RDAs than did their moderate counterparts; these high consumers more frequently selected foods from categories likely to contain sugar-rich foods but weighed significantly less than did moderate consumers. Thus, different approaches to defining intake of added sugars revealed 2 patterns of high consumption of added sugars with different levels of nutritional risk. Conditions of overweight were not associated with high intake of added sugars. Educational efforts, therefore, should focus on those consumers who tended to substitute foods rich in added sugars for more nutritionally desirable foods.
KW - body weight
KW - Diet
KW - diet studies
KW - intake
KW - Sugars
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
KW - Sugar and Sugar Products (QQ020)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931464758&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in prevalence and magnitude of vitamin and mineral supplement usage and correlation with health status.
AU - Bender, M. M.
AU - Levy, A. S.
AU - Schucker, R. E.
AU - Yetley, E. A.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 9
SP - 1096
EP - 1101
SN - 0002-8223
AD - Bender, M. M.: Division of Consumer Studies, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931468308. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - The 1980 Food and Drug Administration Vitamin and Mineral Supplement Use Survey and the 1986 National Health Interview Survey used similar questions and procedures to estimate and identify trends in the prevalence and magnitude of supplement usage in the USA. A comparison of the 2 surveys revealed that prevalence of supplement use among adults decreased slightly, from 42% in 1980 to 38% in 1986. The magnitude of supplement use also decreased; users reported taking a mean of 2.15 supplements in 1980 compared with a mean of 1.77 in 1986. The prevalence of supplement users identified as light users increased from 42% in 1980 to 57% in 1986. Supplement usage was more likely and more intense among individuals who had one or more health problems and among individuals who perceived their health as very good or excellent. The findings indicate that supplement usage remains a widespread behaviour linked to popular conceptions of good health and well-being but one that is susceptible to change.
KW - diet studies
KW - health
KW - Mineral supplements
KW - Vitamin supplements
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468308&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - More effective nutrition label formats are not necessarily preferred.
AU - Levy, A. S.
AU - Fein, S. B.
AU - Schucker, R. E.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 10
SP - 1230
EP - 1234
SN - 0002-8223
AD - Levy, A. S.: Division of Consumer Studies, Center for Food and Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931468344. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - An experimental design was used to compare performance and preference for 5 nutrition label formats. 4 performance measures, accuracy and false-positives in identifying nutrient differences, time required and correctness in judging which product was more nutritious, were derived from a product-comparison task. A sample of 1460 food shoppers over 18 years old was recruited by a shopping mall-intercept method. Results demonstrated that preferences and performance do not necessarily agree. The Control Format, which had no nutrition profile information, performed the best but was liked the least. The Adjectival format, which provided nutrition profile information in the form of descriptive adjectives, was the most preferred. Results also showed that listing Daily Reference Values or nutrition profile aids increased preference but either did not affect performance or decreased it, depending on the specific aid and performance measure. Formats that some subjects liked for having adequate information others disliked for being hard to use. Formats that some subjects liked for being easy to use others disliked for having inadequate information. Age, education and race were related to all of the performance measures except judgement of relative nutrition. Only gender was related to preference. Results are useful as guidance for the development of consumer education materials.
KW - consumer preferences
KW - Foods
KW - labelling
KW - USA
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Supply, Demand and Prices (EE130)
KW - Human Nutrition (General) (VV100)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468344&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition labeling of raw fruit, vegetables, and fish.
AU - Pennington, J. A. T.
AU - Wilkening, V. L.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1992///
VL - 92
IS - 10
SP - 1250
EP - 1254, 1257
SN - 0002-8223
AD - Pennington, J. A. T.: Office of Nutrition and Food Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931468346. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - In response to certain requirements of the Nutrition Labeling and Education Act (USA), of 1990 (the 1990 amendments), the Food and Drug Administration (FDA) developed a voluntary nutrition labelling programme for the 20 most frequently consumed raw fruit, vegetables and fish in the USA. FDA used data on retail sales and food consumption to identify which foods to include in the programme and developed guidelines for retailers to use in setting up the labelling programme in their stores. FDA provided interim nutrition labelling data for retail use. The data are to be revised and updated at least every 2 years. A representative sample of 2000 grocery stores will be used to assess compliance of retailers with the nutrition labelling guidelines. Substantial compliance with the guidelines is defined as compliance by 60% of the 2000 stores.
KW - Fish
KW - food legislation
KW - Fruit
KW - labelling
KW - Nutrition programmes
KW - Vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - labeling
KW - labels
KW - nutrition programs
KW - United States of America
KW - vegetable crops
KW - Animal Nutrition (Production Responses) (LL520)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931468346&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a genomic group of Borrelia burgdorferi through signature nucleotide analysis and 16S rRNA sequence determination.
AU - Marconi, R. T.
AU - Garon, C. F.
JO - Journal of General Microbiology
JF - Journal of General Microbiology
Y1 - 1992///
VL - 138
IS - 3
SP - 533
EP - 536
SN - 0022-1287
AD - Marconi, R. T.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930515927. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - As part of a continuing effort to assess genetic variation among isolates of B. burgdorferi, the 16S rRNA signature nucleotide makeup of 2 tick (Ixodes persulcatus) isolates from Russia were determined. Signature nucleotides were identified via reverse transcriptase primer extension sequencing of select regions of the 16S rRNA molecule. In addition, the near complete 16S rRNA sequence of one of the isolates, R-IP3, was determined and utilized in a phylogenetic assessment. The sequence was aligned with the 16S rRNA sequences of other B. burgdorferi isolates, as well as with other Borrelia species (B. anserina, B. coriaceae, B. hermsii). Distance matrix analyses were performed and a phylogenetic tree was constructed. These analyses demonstrated that these isolates belong to a third previously unidentified genomic group of B. burgdorferi.
KW - genome analysis
KW - molecular genetics
KW - Nucleotide sequences
KW - Ribosomal RNA
KW - Russia
KW - Borrelia burgdorferi
KW - Spirochaetaceae
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - bacterium
KW - biochemical genetics
KW - DNA sequences
KW - rRNA
KW - Russian Federation
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515927&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cystitis induced by infection with the Lyme disease spirochete, Borrelia burgdorferi, in mice.
AU - Czub, S.
AU - Duray, P. H.
AU - Thomas, R. E.
AU - Schwan, T. G.
JO - American Journal of Pathology
JF - American Journal of Pathology
Y1 - 1992///
VL - 141
IS - 5
SP - 1173
EP - 1179
SN - 0002-9440
AD - Czub, S.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Arthropod-Borne Diseases Section, Hamilton, MT 59840, USA.
N1 - Accession Number: 19940805925. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Previous studies have shown that the urinary bladder is a consistent source for isolating B. burgdorferi from both experimentally infected and naturally exposed rodents. In this study, histopathological changes in the urinary bladder were examined in a variety of rodents experimentally infected with B. burgdorferi. Spirochaetes were cultured from the urinary bladder of all 35 mice inoculated with low-passaged spirochaetes, but none were cultured from the kidneys of the same mice. The pathological changes observed most frequently in the urinary bladder were the presence of lymphoid aggregates, vascular changes and thickening of the vessel walls. The results demonstrated that 93% of the animals examined had a cystitis associated with spirochaetal infection.
KW - bladder
KW - cystitis
KW - Lyme disease
KW - pathology
KW - Borrelia burgdorferi
KW - mice
KW - Spirochaetaceae
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - lyme borreliosis
KW - urinary bladder
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805925&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Obesity among Navajo adolescents. Relationship to dietary intake and blood pressure.
AU - Gilbert, T. J.
AU - Percy, C. A.
AU - Sugarman, J. R.
AU - Benson, L.
AU - Percy, C.
JO - AJDC, American Journal of Diseases of Children
JF - AJDC, American Journal of Diseases of Children
Y1 - 1992///
VL - 146
IS - 3
SP - 289
EP - 295
SN - 0002-922X
AD - Gilbert, T. J.: Shiprock Public Health Service Hospital, PO Box 160, Shiprock, NM 87420, USA.
N1 - Accession Number: 19941400688. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - Anthropometric measurements, blood pressures, dietary intakes and self-perceived body image were evaluated in 352 Navajo Indian adolescents. 33% of girls and 25% of boys were obese according to a body mass index criterion. Navajo adolescents tended to have larger skin folds than their white (National Health and Nutrition Examinations Survey II) and Mexican American (Hispanic Health and Nutrition Examination Survey) counterparts, with the greater difference in the subscapular skin folds indicating a greater amount of truncal rather than peripheral fat. When divided into lower, middle and upper thirds of body mass index, systolic and diastolic blood pressures were positively related with increasing body mass index for girls, and systolic blood pressure and body mass index were related among boys. The high prevalence of obese adolescents and the apparent effect of increased weight on blood pressure in this population indicate the need for interventions aimed at improving dietary habits and fitness.
KW - adolescents
KW - American Indians
KW - anthropometric dimensions
KW - blood pressure
KW - body fat
KW - children
KW - diet
KW - ethnic groups
KW - obesity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anthropometric measurements
KW - fatness
KW - teenagers
KW - United States of America
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941400688&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The hamster immune response to tick-transmitted Borrelia burgdorferi differs from the response to needle-inoculated, cultured organisms.
AU - Roehrig, J. T.
AU - Piesman, J.
AU - Hunt, A. R.
AU - Keen, M. G.
AU - Happ, C. M.
AU - Johnson, B. J. B.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1992///
VL - 149
IS - 11
SP - 3648
EP - 3653
SN - 0022-1767
AD - Roehrig, J. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19940500302. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The human immune response to natural infection with B. burgdorferi appears to differ from that seen in small mammals infected by needle inoculation. In humans, antibody to outer surface proteins A and B (OspA and OspB) is not detectable until late in infection, but small mammals inoculated with B. burgdorferi produce early antibody to OspA and OspB. To investigate this disparity, the immune response in hamsters to B. burgdorferi after needle inoculation was compared with cultured organisms or infected tick (Ixodes dammini [i.e. I. scapularis "northern" form]) homogenates with the immune response after tick transmitted (natural) infection. It was determined that the antibody response to OspA and OspB after natural infection of hamsters is similar to that seen in humans, and differs from the antibody response after hamster infection by needle inoculation. High titres of antibody to OspA and OspB were undetectable even 42 weeks after bite by B. burgdorferi-infected ticks. The failure to produce antibody to OspA and OspB was not dependent on challenge dose, because animals inoculated by needle with low doses (1×105 to 1×106 cells) of B. burgdorferi produced antibody to OspA and OspB. A rapid but limited anti-41-kDa response was observed. One possible new antigen, 43 kDa (p43), was identified. The antibody response to p43 was independent of the route of inoculation. The results suggested that the hamster immune response to tick-transmitted B. burgdorferi differs from the response to needle inoculated, cultured organisms.
KW - antibodies
KW - disease transmission
KW - disease vectors
KW - immune response
KW - infection
KW - laboratory animals
KW - Lyme disease
KW - transmission
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - hamsters
KW - Ixodes scapularis
KW - Ixodidae
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein.
AU - Guirakhoo, F.
AU - Bolin, R. A.
AU - Roehrig, J. T.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1992///
VL - 191
IS - 2
SP - 921
EP - 931
SN - 0042-6822
AD - Guirakhoo, F.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950506366. Publication Type: Journal Article. Language: English. Number of References: 45 ref.
N2 - To study the role of the precursor to the membrane protein (prM) in Flavivirus maturation, the proteolytic processing of the Murray Valley encephalitis (MVE) virus prM to membrane protein in infected cells was inhibited by adding the acidotropic agent ammonium chloride late in the virus replication cycle. Viruses purified from supernatants of ammonium chloride-treated cells contained prM protein and were unable to fuse C6/36 mosquito cells from without. When ammonium chloride was removed from the cells, both the processing of prM and the fusion activity of the purified viruses were partially restored. By using monoclonal antibodies (MAbs) specific for the envelope (E) glycoprotein of MVE virus, it was found that at least 3 epitopes were less accessible to their corresponding antibodies in the prM-containing MVE virus particles. Amino-terminal sequencing of proteolytic fragments of the E protein which were reactive with sequence-specific peptide antisera or MAb enabled us to estimate the site of the E protein interacting with the prM to be within amino acids 200 to 327. Since prM-containing viruses were up to 400-fold more resistant to a low pH environment, it is concluded that the E-prM interaction might be necessary to protect the E protein from irreversible conformational changes caused by maturation into the acidic vesicles of the exocytic pathway.
KW - amino acid sequences
KW - arboviruses
KW - epitopes
KW - glycoproteins
KW - pH
KW - viral proteins
KW - Murray Valley encephalitis virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenic determinants
KW - arthropod-borne viruses
KW - hydrogen ion concentration
KW - potential of hydrogen
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Benefits and costs of using an orally absorbed vaccine to control rabies in raccoons.
AU - Uhaa, I. J.
AU - Dato, V. M.
AU - Sorhage, F. E.
AU - Beckley, J. W.
AU - Roscoe, D. E.
AU - Gorsky, R. D.
AU - Fishbein, D. B.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1992///
VL - 201
IS - 12
SP - 1873
EP - 1882
SN - 0003-1488
AD - Uhaa, I. J.: Viral & Rickettsial Zoonoses Branch, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, G13, Atlanta, CA 30333, USA.
N1 - Accession Number: 19932278639. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Veterinary Science; Veterinary Science; Agricultural Biotechnology
N2 - In November 1989, the epidemic of rabies affecting raccoons in the mid-Atlantic states reached New Jersey. An economic evaluation was conducted in 2 countries first affected by the disease to estimate the costs of the disease outbreak and to assess the costs and benefits of orally administering a newly developed recombinant rabies vaccine to prevent further spread of the disease. Data on expenditures associated with prevention of rabies in man and domestic animals were collected and analysed for 1988 (before the outbreak) and 1990 (first full year of the outbreak). Benefit-cost ratios were calculated and used to evaluate the economic advisability of the vaccine at various vaccination programme alternatives. Two indices of capital investment analysis, payback period and net present value, were used to evaluate the economic benefits of the rabies vaccine. Expenditures were estimated to be $1 952 014 in 1990 (primarily for pet animal vaccinations), compared with 768 488 in 1988. Benefit-cost ratios ranged from 2.21 for the most expensive vaccination programme alternative to 6.80 for the least expensive alternative. The payback period varied from 0.69 to 2.11 years, and the net present value ranged from $2 105 453 to $4 877 452. The high costs of this epidemic necessitated the reallocation of scarce public health resources to various rabies prevention activities, particularly the vaccination of dogs. This study also demonstrated the usefulness of benefit-cost analysis in developing public health strategies. Although the mass application of this recombinant vaccine was found to be economically beneficial, it was concluded that other qualitative considerations must be used to supplement these findings.
KW - Biotechnology
KW - Cost benefit analysis
KW - Disease control
KW - Disease prevention
KW - Economics
KW - rabies
KW - recombinant vaccines
KW - vaccination
KW - vaccines
KW - Viral diseases
KW - Wild animals
KW - USA
KW - Procyon lotor
KW - Procyonidae
KW - rabies virus
KW - Procyon
KW - Procyonidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - viral infections
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Economics (General) (EE100) (Discontinued June 2002)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Agricultural Economics (EE110)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The safety of foods developed by biotechnology.
AU - Kessler, D. A.
AU - Taylor, M. R.
AU - Maryanski, J. H.
AU - Flamm, E. L.
AU - Kahl, L. S.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1992///
VL - 256
IS - 5065
SP - 1747
EP - 1749, 1832
SN - 0036-8075
AD - Kessler, D. A.: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19921630622. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Agricultural Biotechnology
N2 - The regulatory framework of the US Food and Drug Administration (FDA), its approach to safety assessment and its scientific basis are explained in the context of biotechnology, particularly foods produced by applying recombinate DNA technology to plants. Examples of 18 traits introduced into transgenic plants are tabulated and a flow chart of the safety assessment procedure is included. In safety assessment of the host plant, toxicants associated with related species should be tested for along with nutrient levels in the host. Allergens from the donor should be evaluated if food is commonly allergenic. Expected effects associated with modified carbohydrates, fats or oils such as unusual or toxic components, nutritional alterations or changes in digestibility should be assessed by the FDA. In general modification of proteins would not require assessment unless there were concerns due to reported toxicity, allergenicity or alteration of biological functions. Potential problems with using animal feeding trials to assess safety of whole foods are mentioned. Substances that have a safe history of use in food and substances that are substantially similar to such substances generally would not require extensive premarket safety testing. Substances that raise safety concerns would be subject to closer inquiry. It is argued that this approach is both scientifically and legally sound and should be adequate to fully protect public health while not inhibiting innovation.
KW - Biotechnology
KW - food
KW - release
KW - risk
KW - safety
KW - USA
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Social Sciences (General) (UU000)
KW - Laws and Regulations (DD500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation of eastern equine encephalitis virus from Aedes albopictus in Florida.
AU - Mitchell, C. J.
AU - Niebylski, M. L.
AU - Smith, G. C.
AU - Karabatsos, N.
AU - Martin, D.
AU - Mutebi, J. P.
AU - Craig, G. B., Jr.
AU - Mahler, M. J.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1992///
VL - 257
IS - 5069
SP - 526
EP - 527
SN - 0036-8075
AD - Mitchell, C. J.: Division of Vector-borne Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19920512616. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - Fourteen strains of eastern equine encephalitis (EEE) vius were isolated from A. albopictus collected by sweeping vegetation in and around a tyre dump in Polk county, Florida, USA, during 6-10 June 1991. The strains of EEE virus were identified by indirect immunofluorescence at the Centers for Disease Control, Fort Collins, Colorado. This represents the first isolation of an arbovirus of proven public health importance in naturally infected A. albopictus from the USA. It is suggested that A. albopictus poses a threat as an epizootic and epidemic vector of EEE virus to humans and equines in endemic areas of the USA.
KW - Arboviruses
KW - Disease vectors
KW - introduced species
KW - Florida
KW - North America
KW - USA
KW - Aedes
KW - Aedes albopictus
KW - Alphavirus
KW - Culicidae
KW - Diptera
KW - eastern equine encephalitis virus
KW - Equine encephalomyelitis virus
KW - Togaviridae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Flow-injection assay of enzyme inhibition in fish using immobilized diamine oxidase.
AU - Hungerford, J. M.
AU - Arefyev, A. A.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 1992///
VL - 261
IS - 1/2
SP - 351
EP - 359
SN - 0003-2670
AD - Hungerford, J. M.: Seafood Products Research Center, US Food and Drug Administration, 22201 23rd Drive S.E., PO Box 3042, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19931466119. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - A flow-injection assay for inhibition of diamine oxidase (DAO) is described. Histamine in decomposed fish was detected and used as the enzyme substrate. Sample extracts were doubly injected; 1 of the 2 resulting sample zones was passed through a reactor containing DAO immobilized to Sepharose. Histamine was detected sequentially in the pristine and enzymically treated zones. The detection chemistry (kinetics-optimizing condensation with phthalic dicarboxaldehyde) allowed the selective detection of histamine. Subsequent calibration with histamine standard and comparison of the 2 peak heights allowed generic detection of compounds inhibiting the DAO-mediated conversion of histamine. It is concluded that this system can detect inhibitors in extracts of decomposed Mahi-Mahi (associated with a Scombroid poisoning outbreak) and that far lower levels of inhibition are observed in fresh fish.
KW - analytical methods
KW - enzyme inhibitors
KW - fish
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modulation of chemical toxicity by modification of caloric intake.
AU - Hart, R. W.
AU - Leakey, J. E. A.
AU - Chou, M.
AU - Duffy, P. H.
AU - Allaben, W. T.
AU - Feuers, R. J.
A2 - Jacobs, M. M.
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
Y1 - 1992///
VL - 322
SP - 73
EP - 81
AD - Hart, R. W.: National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19931458679. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - In 1985, the US National Institute of Aging and the National Center for Toxicological Research (NCTR) initiated an extensive collaborative programme (Project Caloric Restriction) to establish a colony of aged, closely controlled and tightly regulated rodents for use in both gerontological and toxicological research. A brief overview of the results of studies concerning modulation of chemical toxicity by energy restriction at the NCTR is presented.
KW - Chemicals
KW - energy deprivation
KW - reviews
KW - toxicity
KW - USA
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Exercise, calories, fat, and cancer
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of aflatoxins in food products by chromatography.
AU - Holcomb, M.
AU - Wilson, D. M.
AU - Trucksess, M. W.
AU - Thompson, H. C., Jr.
JO - Journal of Chromatography
JF - Journal of Chromatography
Y1 - 1992///
VL - 624
IS - 1/2
SP - 341
EP - 352
SN - 0021-9673
AD - Holcomb, M.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19941407408. Publication Type: Journal Article. Language: English. Number of References: 97 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Several chromatographic methods for estimation of aflatoxins in foods are reviewed, including the more traditional thin layer and newer HPLC techniques.
KW - aflatoxins
KW - analytical methods
KW - chromatography
KW - contamination
KW - estimation
KW - foods
KW - liquid chromatography
KW - mycotoxins
KW - reviews
KW - thin layer chromatography
KW - analytical techniques
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of short-term feeding of barley oil extract containing naturally occurring tocotrienols on the immune response of rats.
AU - Babu, U. S.
AU - Jenkins, M. Y.
AU - Mitchell, G. V.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1992///
VL - 669
SP - 317
EP - 319
SN - 0077-8923
AD - Babu, U. S.: Division of Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931459857. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 6 ref. Registry Number: 1406-18-4. Subject Subsets: Human Nutrition
KW - Barley
KW - Immune response
KW - intake
KW - Plant oils
KW - tocotrienols
KW - Vitamin E
KW - USA
KW - Hordeum vulgare
KW - rats
KW - Hordeum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immunity reactions
KW - immunological reactions
KW - New views on the function and health effects of vitamins
KW - United States of America
KW - vegetable oils
KW - Host Resistance and Immunity (HH600)
KW - Human Physiology and Biochemistry (VV050)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plague - United States, 1992.
JO - Morbidity and Mortality Weekly
JF - Morbidity and Mortality Weekly
Y1 - 1992///
VL - 41/42
SP - 787
EP - 790
AD - US Department of Health and Human Services/Public Health Service.
N1 - Accession Number: 19940803626. Publication Type: Journal Article. Corporate Author: US Department of Health Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - From January 1 to October 15, 1992, 11 human plague cases were reported in the USA. 3 of the cases occurred among young children and 10 of the cases occurred among males. 4 cases were reported from Arizona and 3 from New Mexico. Fleas were implicated as the source of infection in 7 cases, domestic cats in 2 and a wild rodent carcass in one. All but one patient recovered with antibiotic treatment. In an editorial note, it is stated that from 1955 to 1991, 336 cases of plague were reported in the USA, and that more than half of these have occurred since 1980. American Indians, especially the Navajo, are disproportionately represented among plague cases in the USA.
KW - American Indians
KW - bacterial diseases
KW - disease vectors
KW - human diseases
KW - plague
KW - vector-borne diseases
KW - Arizona
KW - New Mexico
KW - USA
KW - man
KW - rodents
KW - Siphonaptera
KW - YERSINIA PESTIS
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Great Plains States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Manuals of food quality control. Pesticide residue analysis in the food control laboratory.
AU - Miller, G.
T2 - FAO Food and Nutrition Paper
JO - FAO Food and Nutrition Paper
JF - FAO Food and Nutrition Paper
Y1 - 1992///
IS - 14/13
SP - ix + 182
EP - ix + 182
SN - 0254-4725
AD - Miller, G.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19942300346. Publication Type: Miscellaneous. Language: English. Subject Subsets: Weeds; Human Nutrition; Horticultural Science; Soyabeans; Agricultural Entomology; Soils & Fertilizers
N2 - This manual is a practical handbook on the analysis of foods for pesticide residue contamination. Sample handling techniques and analytical methods to isolate qualitatively or quantitatively both pesticides and industrial contaminants in food are discussed, including the preparation, extraction, clean-up and separation techniques for the analysis of fruits, vegetables, milk, oilseeds, dry low-fat foods and fatty foods. The analysis of like residues by broad multi-residue detection methods and individual residue methods for singular residues are suggested. The determination of residues in crop soils is also mentioned.
KW - agricultural entomology
KW - analysis
KW - analytical methods
KW - arable soils
KW - determination
KW - environment
KW - extraction
KW - foods
KW - fruit crops
KW - herbicide residues
KW - herbicides
KW - insecticide residues
KW - insecticides
KW - milk
KW - nontarget effects
KW - oilseed plants
KW - pesticide residues
KW - pesticides
KW - residues
KW - sample processing
KW - soil
KW - soil types (cultural)
KW - soyabean products
KW - techniques
KW - vegetables
KW - analytical techniques
KW - cultural soil types
KW - oilseed crops
KW - preparation of samples
KW - soybean products
KW - vegetable crops
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Grain-handling fatalities in production agriculture, 1985-1989.
AU - Snyder, K. A.
AU - Bobick, T. G.
AU - Hanz, J. L.
AU - Myers, J. R.
T2 - Paper - American Society of Agricultural Engineers
JO - Paper - American Society of Agricultural Engineers
JF - Paper - American Society of Agricultural Engineers
Y1 - 1992///
IS - 92-5509
SP - 13
EP - 13
SN - 0149-9890
AD - Snyder, K. A.: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 19932458045. Publication Type: Miscellaneous. Language: English. Number of References: 15 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Agricultural Engineering
N2 - Grain- and silage-handling deaths were identified from data maintained by the USA Division of Safety Research, National Institute for Occupational Safety and Health, to help target intervention efforts. Cases with similar circumstances, environments, or mechanisms were grouped into 26 categories. Suffocations, auger entanglements, falls, and electrocutions from contacting power lines caused 53% of the 236 fatalities. Sixty-eight percent of the deaths occurred in the West North Central and East North Central census regions. Two age groups, 25 to 34 and 55 to 64 years old, comprised 42% of the deaths.
KW - accidents
KW - Augers
KW - Bins
KW - grain
KW - Handling
KW - safety
KW - silage
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Crop Produce (QQ050)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Farm and Horticultural Structures (NN300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932458045&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Preventing logging fatalities in Alaska.
AU - Myers, M. L.
AU - Manwaring, J. C.
T2 - Paper - American Society of Agricultural Engineers
JO - Paper - American Society of Agricultural Engineers
JF - Paper - American Society of Agricultural Engineers
Y1 - 1992///
IS - 92-7508
SP - 13
EP - 13
SN - 0149-9890
AD - Myers, M. L.: National Institute for Occupational Safety and Health, Atlanta, GA, USA.
N1 - Accession Number: 19932460435. Publication Type: Miscellaneous. Language: English. Number of References: 23 ref. Subject Subsets: Agricultural Engineering; Forest Products
N2 - Logging has the second highest rate of occupational fatalities in Alaska, USA. The U.S. National Institute for Occupational Safety and Health (NIOSH) initiated a programme in Alaska to prevent the high rate of injuries and fatalities in that state. The results of investigations are presented with recommendations for preventing logging fatalities and for further research.
KW - accident prevention
KW - Forestry
KW - logging
KW - safety
KW - Alaska
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - timber extraction
KW - timber harvesting
KW - United States of America
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Logging and Wood Processing (KK515)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Crop Harvesting Equipment (NN453) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932460435&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Approaches to the detection and confirmation of drug residues in milk.
AU - Carson, M. C.
AU - Heller, D. N.
AU - Kijak, P. J.
AU - Thomas, M. H.
A2 - Agarwal, V. K.
T2 - Analysis of antibiotic/drug residues in food products of animal origin. Proceedings of an Americal Chemical Society Agricultural and Food Chemistry Division Symposium, New York, USA, 25-30 August 1991.
JO - Analysis of antibiotic/drug residues in food products of animal origin. Proceedings of an Americal Chemical Society Agricultural and Food Chemistry Division Symposium, New York, USA, 25-30 August 1991.
JF - Analysis of antibiotic/drug residues in food products of animal origin. Proceedings of an Americal Chemical Society Agricultural and Food Chemistry Division Symposium, New York, USA, 25-30 August 1991.
Y1 - 1992///
SP - 107
EP - 118
CY - New York; USA
PB - Plenum Press
SN - 0306441993
AD - Carson, M. C.: Division of Veterinary Medical Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Beltsville MD 20705, USA.
N1 - Accession Number: 19930461602. Publication Type: Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science
KW - chromatography
KW - Cows
KW - detection
KW - drug residues
KW - Drugs
KW - milk
KW - milk hygiene
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - medicines
KW - pharmaceuticals
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930461602&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vector/spirochete relationships of arthropod-borne borrelioses.
AU - Burgdorfer, W.
A2 - Munderloh, U.G.
A2 - Kurtti, T.J.
T2 - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JO - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JF - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
Y1 - 1992///
SP - 111
EP - 120
CY - St Paul, Minnesota; USA
PB - University of Minnesota
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19950506534. Publication Type: Conference paper. Language: English. Number of References: 35 ref.
N2 - This paper includes a general table of arthropod-borne borrelioses, their vectors, reservoirs, distributions and disease names.
KW - disease vectors
KW - host parasite relationships
KW - pathogens
KW - reviews
KW - tickborne diseases
KW - Argasidae
KW - Borrelia burgdorferi
KW - Borrelia recurrentis
KW - Ixodes persulcatus
KW - Ixodes ricinus
KW - Ixodidae
KW - Ornithodoros
KW - Pediculus humanus
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Argasidae
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - bacterium
KW - body louse
KW - parasite host relationships
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506534&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Cholera infection and poisoning.
AU - Kaysner, C. A.
A2 - Tu, A. T.
T2 - Food poisoning.
JO - Food poisoning.
JF - Food poisoning.
Y1 - 1992///
SP - 155
EP - 170
CY - New York; USA
PB - Marcel Dekker
SN - 0824786521
AD - Kaysner, C. A.: Seafood Products Research Center, United States Food and Drug Administration, Bothell, Washington, USA.
N1 - Accession Number: 19931462247. Publication Type: Miscellaneous. Language: English. Number of References: 88 ref. Subject Subsets: Human Nutrition
N2 - Cholera is a gastrointestinal disease caused by a bacterium, Vibrio cholera serogroup 0:1, that is endemic to parts of Asia, primarily India and the Ganges basin. In the early 1970s, cholera caused by the EI Tor biotype appeared in the USA, though the classical biotype has not been identified as being responsible for illness in this country. The epidemiology (in the USA), medical aspects and toxicological properties of this infection are reviewed.
KW - biodeterioration
KW - Cholera
KW - Food poisoning
KW - Foodborne diseases
KW - Foods
KW - Gastrointestinal diseases
KW - Infections
KW - pathogens
KW - reviews
KW - USA
KW - Vibrio cholerae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462247&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Transovarial transmission: an effective ecological means for the survival of tick-borne spotted fever group rickettsiae.
AU - Burgdorfer, W.
A2 - Munderloh, U.G.
A2 - Kurtti, T.J.
T2 - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JO - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
JF - First International Conference on Tick-borne Pathogens at the Host-Vector Interface: An Agenda for Research: Proceedings and abstracts, September 15-18, 1992, University of Minnesota College of Agriculture, Department of Entomology, and Minnesota Extension Service, Saint Paul, Minnesota, USA.
Y1 - 1992///
SP - 265
EP - 272
CY - St Paul, Minnesota; USA
PB - University of Minnesota
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19950506554. Publication Type: Conference paper. Language: English. Number of References: 13 ref.
KW - disease vectors
KW - host parasite relationships
KW - infections
KW - pathogens
KW - Rocky Mountain spotted fever
KW - tickborne diseases
KW - transovarial transmission
KW - Dermacentor andersoni
KW - Dermacentor variabilis
KW - Rickettsia montanensis
KW - Rickettsia rhipicephali
KW - Rickettsia rickettsii
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - parasite host relationships
KW - Rickettsia montana
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506554&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Analytical methods for marine toxins.
AU - Hungerford, J. M.
AU - Wekell, M. M.
A2 - Tu, A. T.
T2 - Food poisoning.
JO - Food poisoning.
JF - Food poisoning.
Y1 - 1992///
SP - 415
EP - 473
CY - New York; USA
PB - Marcel Dekker
SN - 0824786521
AD - Hungerford, J. M.: Seafood Products Research Center, US Food and Drug Administration, Bothell, Washington, USA.
N1 - Accession Number: 19931462263. Publication Type: Miscellaneous. Language: English. Number of References: 16 pp. of ref. Subject Subsets: Human Nutrition
N2 - This chapter reviews analytical methods developed for the detection and quantitation of various marine toxins. Toxins included in this review are: paralytic shellfish poisoning (saxitoxins); tetrodotoxins; amnesic shellfish poisoning (domoic acid); tetramine poisoning (tetramethylammonium ion); neurotoxic shellfish poisoning (brevetoxins); diarrhetic shellfish poisoning (DSP); ciguatera; and palytoxin.
KW - analytical methods
KW - detection
KW - Fish
KW - Fish toxins
KW - Food poisoning
KW - reviews
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462263&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Safety of vitamin and mineral supplements.
AU - Hathcock, J. N.
A2 - Bendich, A.
A2 - Butterworth, C. E., Jr.
T2 - Micronutrients in health and in disease prevention.
JO - Micronutrients in health and in disease prevention.
JF - Micronutrients in health and in disease prevention.
Y1 - 1992///
SP - 439
EP - 450
CY - New York; USA
PB - Marcel Dekker
SN - 0824785398
AD - Hathcock, J. N.: Experimental Nutrition Branch, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19931462369. Publication Type: Miscellaneous. Language: English. Number of References: 61 ref. Subject Subsets: Human Nutrition
N2 - The toxicity of various vitamins and minerals are reviewed. Lowest reported levels for adverse effects by selected nutrients are presented.
KW - Mineral supplements
KW - reviews
KW - safety
KW - toxicity
KW - Vitamin supplements
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462369&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes).
AU - Robbins, R. G.
AU - Keirans, J. E.
T2 - Systematics and ecology of the subgenus Ixodiopsis (Acari: Ixodidae: Ixodes).
Y1 - 1992///
CY - Lanham, Maryland; USA
PB - Entomological Society of America
SN - 0938522388
AD - Robbins, R. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, c/o Department of Entomology, Museum Support Center, Smithsonian Institution, Washington, DC 20560, USA.
N1 - Accession Number: 19950503710. Publication Type: Book. Language: English. Number of References: 16 pp. of ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This monograph endeavours to: (1) summarize and evaluate previous observations on the morphology, hosts and distribution of each species in the Ixodes tick subgenus Ixodiopsis; (2) present the results of the authors' original research on the taxonomy and bionomics of this close-knit assemblage; and (3) analyse the evolutionary and zoogeographic history of this group in the light of current phylogenetic methodology. This Holarctic subgenus, often referred to as the "Ixodes angustus group", contains 7 species: I. angustus, I. eastoni, I. ochotonae, I. pomerantzevi, I. soricis, I. stromi and I. woodi. This book contains a diagnosis of Ixodiopsis, keys (to males, females, nymphs and larvae), synopses of species, material examined and sections on phylogenetics, ecology and zoogeography. There are 2 appendixes: a glossary, and a classified host-parasite list. A comprehensive index to the tick species completes the book.
KW - biosystematics
KW - ecology
KW - ectoparasites
KW - geographical distribution
KW - Holarctic Region
KW - hosts
KW - keys
KW - phylogeny
KW - redescriptions
KW - taxonomy
KW - wild animals
KW - zoogeography
KW - Asia
KW - Europe
KW - North America
KW - Acari
KW - Arachnida
KW - insectivores
KW - Ixodes
KW - Lagomorpha
KW - mammals
KW - rodents
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - America
KW - animal geography
KW - Ixodes angustus
KW - Ixodes eastoni
KW - Ixodes ochotonae
KW - Ixodes pomerantzevi
KW - Ixodes soricis
KW - Ixodes stromi
KW - Ixodes woodi
KW - Ixodiopsis
KW - revision
KW - systematics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Biological Resources (Animal) (PP710)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid methods for the detection of Salmonella in foods.
AU - Feng, P.
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
Y1 - 1993///
VL - 1
IS - 2
SP - 119
EP - 131
SN - 1021-9498
AD - Feng, P.: Division of Microbiological Studies Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204 USA.
N1 - Accession Number: 19951412248. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - foods
KW - salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412248&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence, genome organization, and comparisons with mitochondrial sequences of other insects.
AU - Beard, C. B.
AU - Mills Hamm, D.
AU - Collins, F. H.
JO - Insect Molecular Biology
JF - Insect Molecular Biology
Y1 - 1993///
VL - 2
IS - 2
SP - 103
EP - 124
SN - 0962-1075
AD - Beard, C. B.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30314-3724, USA.
N1 - Accession Number: 19930518066. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2 - The entire 15 363 bp mitochondrial genome was cloned and sequenced from the mosquito A. gambiae. With respect to the protein-coding genes, rRNA genes and the control region, the gene order was identical to the reported for other insects. There were significant differences, however, in the position and orientation of specific tRNA loci. The overall nucleotide composition was heavily biased towards adenine and thymine, which accounted for 77.6% of all nucleotides. Comparisons were made with the mitochondrial genomes of other insects on the basis of genome size and organization, DNA and putative amino acid sequence data, nucleotide substitutions, codon usage and bias, and patterns of AT enrichment.
KW - biotechnology
KW - genes
KW - mitochondrial DNA
KW - molecular genetics
KW - nucleotide sequences
KW - Anopheles gambiae
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - DNA sequences
KW - mosquitoes
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Aquatic Biology and Ecology (MM300)
KW - Animal Breeding and Genetics (LL200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930518066&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The epidemiology of human T-lymphotropic virus types I and II.
AU - Kaplan, J. E.
AU - Khabbaz, R. F.
JO - Reviews in Medical Virology
JF - Reviews in Medical Virology
Y1 - 1993///
VL - 3
IS - 3
SP - 137
EP - 148
SN - 1052-9276
AD - Kaplan, J. E.: Retrovirus Diseases Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942023523. Publication Type: Journal Article. Language: English. Number of References: 129 ref. Subject Subsets: Public Health
N2 - This review examines the structure of the HTLVs, serological testing for antigen and antibodies, the geographical distribution of both viruses, risk factors for infection, transmission, and disease associations (none as yet for HTLV-II).
KW - Diagnosis
KW - Epidemiology
KW - HTLV infections
KW - Molecular biology
KW - Pathology
KW - reviews
KW - Serology
KW - Transmission
KW - Virology
KW - Deltaretrovirus
KW - Human T-cell lymphotropic virus
KW - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE I
KW - HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE II
KW - retroviridae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Deltaretrovirus
KW - Human T-cell lymphotropic virus
KW - HTLV-BLV group
KW - human T lymphotropic virus infections
KW - human T-cell leukaemia virus infections
KW - human T-cell lymphotropic virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942023523&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of soft tissue sarcoma deaths in cohorts exposed to dioxin and to chlorinated naphthalenes.
AU - Suruda, A. J.
AU - Ward, E. M.
AU - Fingerhut, M. A.
AU - Sinks, T.
JO - Epidemiology
JF - Epidemiology
Y1 - 1993///
VL - 4
IS - 1
SP - 14
EP - 19
SN - 1044-3983
AD - Suruda, A. J.: (M.A. Fingerhut) US Department of Health and Human Services, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19932023514. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Identification of soft tissue sarcomas (STSs) in epidemiologic mortality studies is complicated by nosologic coding rules that require that STSs arising in a visceral organ must be coded in the International Classification of Diseases (ICD) category for that organ, rather than in the ICD category for malignant neoplasms of connective tissue. Moreover, prior studies have shown poor agreement between diagnoses recorded on death certificates compared with those in hospital records for these tumors. [The authors] reviewed deaths from STS among workers in a registry of 6716 dioxin-exposed workers at the [US] National Institute for Occupational Safety and Health (NIOSH) and in a NIOSH cohort mortality study of 10 240 workers exposed to chlorinated naphthalenes. [The authors] identified 19 subjects with STSs. Of these, 17 (89%) were identifiable by reading the entries on selected death certificates, and two (11%) were found only by reviewing medical records of cases coded to ICD categories likely to have contained STS. Of the 17 STSs identified from death certificates, only 9 (53%) had been coded as underlying cause of death to the ICD category "malignant neoplasms of soft and connective tissue." Medical records were obtained for 14 of the 17 cases (82%), and in each case, the STS diagnosis was verified. Tissue blocks from tumours were available for review in 9 of the 17 cases identified from death certificates, and the diagnosis of STS was verified in 7 (78%). Nosologic rules reduce the sensitivity of cohort mortality studies to detect excesses of STS. Development of referent rates based on histologic coding, such as the International Classification of Diseases for Oncology (ICD-O) system, would allow better study of tumors such as STS. [The same issue contains an editorial on misclassified sarcomas and confounded dioxin exposure (T. Sinks, pp. 3-6).]AS
KW - dioxins
KW - exposure
KW - factory workers
KW - occupations
KW - Toxicology
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - America (North)
KW - mortality studies
KW - sarcoma identification
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023514&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of dietary supplements for nutritional, toxic, and other elements.
AU - Hight, S. C.
AU - Anderson, D. L.
AU - Cunningham, W. C.
AU - Capar, S. G.
AU - Lamont, W. H.
AU - Sinex, S. A.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1993///
VL - 6
IS - 2
SP - 121
EP - 139
SN - 0889-1575
AD - Hight, S. C.: Elemental Research Branch (HFS-338), US Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19931467903. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - 36 elements were estimated in 42 dietary supplements using square wave anodic stripping voltammetry, inductively coupled plasma-atomic emission spectroscopy, instrumental neutron and prompt gamma-ray activation analysis and flame and graphite furnace atomic absorption spectroscopy. This multielement capability enabled estimation of concentrations of nutritional and toxic elements.
KW - analytical methods
KW - food composition
KW - food supplements
KW - minerals
KW - nutrients
KW - toxic substances
KW - trace elements
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - microelements
KW - poisons
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931467903&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - CD4+ T-lymphocyte counts among seronegative heterosexual partners of persons infected with human immunodeficiency virus type 1.
AU - O'Brien, T. R.
AU - VanDevanter, N.
AU - Paxton, H.
AU - Polan, C.
AU - Holmberg, S. D.
T2 - Journal of Acquired Immune Deficiency Syndromes
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
Y1 - 1993///
VL - 6
IS - 12
SP - 1374
EP - 1375
SN - 0894-9255
AD - O'Brien, T. R.: Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19942005092. Publication Type: Correspondence. Language: English.
KW - CD4+ lymphocytes
KW - HIV infections
KW - Immunology
KW - CD4+ cells
KW - human immunodeficiency virus infections
KW - idiopathic CD4 lymphocytopenia
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005092&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malaria: principles of prevention and treatment.
AU - Zucker, J. R.
AU - Campbell, C. C.
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
Y1 - 1993///
VL - 7
IS - 3
SP - 547
EP - 567
SN - 0891-5520
AD - Zucker, J. R.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19940802393. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Protozoology
N2 - This review of malaria covers: life cycle; epidemiology (global, and in the USA); chemotherapeutics; prevention; chemoprophylaxis; presentation of malaria illness; diagnostics; treatment; special clinical problems (pregnant women, pediatric cases, congenital malaria, chloroquine-resistant P. vivax); medications under development.
KW - control
KW - drug therapy
KW - human diseases
KW - parasites
KW - reviews
KW - Apicomplexa
KW - man
KW - Plasmodiidae
KW - Plasmodium
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodiidae
KW - chemotherapy
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940802393&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consortium approaches to the delivery of HIV services under the Ryan White CARE Act.
AU - McKinney, M. M.
JO - AIDS and Public Policy Journal
JF - AIDS and Public Policy Journal
Y1 - 1993///
VL - 8
IS - 3
SP - 115
EP - 125
SN - 0887-3852
AD - McKinney, M. M.: Bureau of Health Resources Development, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 19942005018. Publication Type: Journal Article. Language: English.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Health care
KW - Health services
KW - HIV infections
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005018&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental infection of Anopheles gambiae s.s., Anopheles freeborni and Anopheles stephensi with Plasmodium malariae and Plasmodium brasilianum.
AU - Collins, W. E.
AU - McClure, H.
AU - Strobert, E.
AU - Skinner, J. C.
AU - Richardson, B. B.
AU - Roberts, J. M.
AU - Galland, G. G.
AU - Sullivan, J.
AU - Morris, C. L.
AU - Adams, S. R.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1993///
VL - 9
IS - 1
SP - 68
EP - 71
SN - 8756-971X
AD - Collins, W. E.: Division of Parasitic Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930515179. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Susceptibility to infection of 2 strains of Anopheles gambiae s.s. [G-3 and ZAN strains], An. freeborni and An. stephensi was determined for 2 closely related malaria parasites, P. malariae and P. brasilianum. Neither strain of An. gambiae supported development of oocyst densities as great as the other 2 anopheline mosquitoes. The ZAN strain of An. gambiae s.s. from Zanzibar was more susceptible to infection with the strain of P. malariae from Uganda [Uganda I/CDC] than the G-3 strain of An. gambiae s.s. from The Gambia. All species and strains of mosquitoes supported complete development to the presence of sporozoites in the salivary glands.\AS<new para>ADDITIONAL ABSTRACT:<new para>Susceptibility to infection of A. gambiae s.s. (G-3 and ZAN strains), A. freeborni and A. stephensi was determined for 2 closely related malaria parasites, P. malariae and P. brasilianum. Neither strain of A. gambiae supported development of oocyst densities as great as the other 2 anopheline mosquitoes. The ZAN strain of A. gambiae s.s. from Zanzibar was more susceptible to infection with the strain of P. malariae from Uganda (Uganda I/CDC) than the G-3 strain of A. gambiae s.s. from The Gambia. All species and strains of mosquitoes supported complete development to the presence of sporozoites in the salivary glands.
KW - Disease vectors
KW - experimental infection
KW - infection
KW - Susceptibility
KW - Anopheles
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Apicomplexa
KW - Culicidae
KW - Diptera
KW - Plasmodiidae
KW - Plasmodium
KW - Plasmodium brasilianum
KW - Plasmodium malariae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Protozoa
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930515179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.
AU - Oravecz, T.
AU - Norcross, M. A.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1993///
VL - 9
IS - 10
SP - 945
EP - 955
SN - 0889-2229
AD - Oravecz, T.: (M.A. Norcross) Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Building 29A, Room 3B10, 8800 Rockville Pike, HFM-541, Bethesda, MD 20892, USA.
N1 - Accession Number: 19942005736. Publication Type: Journal Article. Language: English.
KW - CD4 antigens
KW - human immunodeficiency viruses
KW - Immunology
KW - Stimulation
KW - T lymphocytes
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Activation
KW - CD4
KW - HUMAN IMMUNODEFICIENCY VIRUS
KW - T cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005736&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins in review.
AU - Pohland, A. E.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1993///
VL - 10
IS - 1
SP - 17
EP - 28
SN - 0265-203X
AD - Pohland, A. E.: Center for Food Safety and Applied Nutrition, FDA, Washington, DC 20204, USA.
N1 - Accession Number: 19931214499. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 42 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Medical & Veterinary Mycology
N2 - Historical perspectives, occurrence/exposure, toxicological effects, regulations and economic effects of mycotoxin contamination of foods and feeds are reviewed with particular reference to ergotism, citreoviridin toxicoses, alimentary toxic aleukia, stachybotryotoxicosis, Balkan endemic nephropathy and aflatoxicoses.
KW - contamination
KW - feeds
KW - foods
KW - Mycotoxins
KW - feeding stuffs
KW - Food contamination, mycotoxins and phycotoxins
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931214499&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis.
AU - Nair, J.
AU - Rouse, D. A.
AU - Bai, G. H.
AU - Morris, S. L.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1993///
VL - 10
IS - 3
SP - 521
EP - 527
SN - 0950-382X
AD - Nair, J.: (S.L. Morris) Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.
N1 - Accession Number: 19942028049. Publication Type: Journal Article. Language: English. Registry Number: 57-92-1. Subject Subsets: Public Health
KW - genes
KW - resistance
KW - streptomycin
KW - Mycobacterium tuberculosis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Pesticide and Drug Resistance (HH410)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942028049&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of imported green coffee beans for pesticide residues.
AU - Jacobs, R. M.
AU - Yess, N. J.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1993///
VL - 10
IS - 5
SP - 575
EP - 577
SN - 0265-203X
AD - Jacobs, R. M.: Food and Drug Administration, 50 UN Plaza Federal Office Building, San Francisco, CA 94102, USA.
N1 - Accession Number: 19951100395. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 2921-88-2, 29232-93-7. Subject Subsets: Human Nutrition; Horticultural Science; Agricultural Entomology; Postharvest Research
N2 - A total of 60 green coffee samples were collected from 21 countries that are major exporters of coffee to the USA. The samples were analysed for organochlorine or organophosphorus compounds, N-methyl carbamates, benomyl groups and EBDC [ethylenebisdithiocarbamate] residues. Chlorpyrifos was found in 3 samples (at 0.01, 0.02 and 0.04 p.p.m.) and pirimiphos-methyl was found in 1 sample (at 0.01 p.p.m.). No detectable pesticide residues were found in 93% of samples. The residues that were found were so small that it was concluded that no regulatory action was warranted.
KW - agricultural entomology
KW - chlorpyrifos
KW - coffee
KW - commodities
KW - imports
KW - insecticide residues
KW - insecticides
KW - nontarget effects
KW - pesticide residues
KW - pesticides
KW - pirimiphos-methyl
KW - residues
KW - stimulant plants
KW - stored products
KW - USA
KW - Coffea
KW - plants
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chlorpyrifos-ethyl
KW - stimulant crops
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951100395&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - How the discovery of Borrelia burgdorferi came about.
AU - Burgdorfer, W.
A2 - Åsbrink, E.
A2 - Hovmark, A.
JO - Clinics in Dermatology
JF - Clinics in Dermatology
Y1 - 1993///
VL - 11
IS - 3
SP - 335
EP - 338
SN - 0738-081X
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19940501409. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
KW - history
KW - Lyme disease
KW - reviews
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Ixodes ricinus
KW - Ixodes scapularis
KW - man
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940501409&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethynylestradiol protection against methyl insufficiency in castrated male Wistar/Furth rats fed a methionine-choline-deficient diet.
AU - Fullerton, F. R.
AU - Greenman, D. L.
AU - Blaydes, B. S.
AU - Poirier, L. A.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1993///
VL - 14
IS - 6
SP - 1237
EP - 1240
SN - 0143-3334
AD - Fullerton, F. R.: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19941404128. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 63-68-3, 62-49-7. Subject Subsets: Human Nutrition
N2 - The interactive effects of dietary methyl insufficiency and the oestrogenic compound ethynylestradiol (EE) on S-adenyosylmethionine (SAM) and S-adenosylhomocysteine (SAH) values were examined in liver, lungs and pancreas of castrated male Wistar/Furth rats. Such effects on hepatic content of 5-methyldeoxycytidine (5-MC) in nuclear DNA were also investigated. Rats were fed on various levels of EE (0, 1 or 10 mg/kg) in: a complete, amino acid-defined diet (diet 1); the same diet lacking choline and methionine and supplemented with 0.9% DL-homocystine (equimolar to methionine) (diet 2); or diet 2 with 0.3% DL-homocystine (diet 2M). Methyl deficiency and EE each independently produced decreased weight gains and increased relative liver weights (relative to total body weight) compared with control rats. Livers from rats fed on diets 2 and 2M without EE had lower SAM values and lower SAM:SAH ratios than did livers from diet 1-fed rats not treated with EE. Hepatic SAM:SAH ratios in diet 1-fed rats were not altered by EE treatment. However, EE treatment increased hepatic contents of SAM and restored SAM:SAH values to normal in rats fed on diets 2 or 2M. Levels of SAM + SAH in livers of rats fed on the low homocystine diet (diet 2M) were less than in those fed on diet 1 or diet 2. Thus, addition of EE at 10 mg/kg gave protection against reduced SAM values and reduced SAM:SAH ratios in liver, but had little effect when added to the methyl-adequate diet. No differences in hepatic 5-MC values were observed in any groups as a result of methyl deficiency or EE treatment. Methyl deprivation alone caused no discernible difference in pancreatic SAM values but did result in a significant increase in SAH values and thus in decreased SAM:SAH ratios. EE had no consistent effect on pancreatic SAM, SAH or SAM:SAH ratios in any diet group examined. Similarly, chronic feeding of diet 2, diet 2M or of EE had no significant effect on SAM contents of lungs, compared with the corresponding values in controls. The protection conferred by EE against SAM insufficiency in livers of rats fed on a methionine- and choline-deficient diet is consistent with the relative insensitivity of female rats to the hepatotoxicity of dietary methyl insufficiency.
KW - amino acids
KW - choline
KW - deficiency
KW - intake
KW - liver
KW - lungs
KW - methionine
KW - neoplasms
KW - oestrogens
KW - pancreas
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - estrogens
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404128&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Asymptomatic hospital foodhandlers should not be screened routinely for intestinal parasites.
AU - Vugia, J.
AU - Griffin, P. M.
T2 - Infection Control and Hospital Epidemiology
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 1993///
VL - 14
IS - 8
SP - 457
EP - 458
SN - 0899-823X
AD - Vugia, J.: Parasitic Diseases Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19940803854. Publication Type: Editorial. Language: English. Number of References: 7 ref. Subject Subsets: Helminthology; Protozoology
N2 - The letter in which Germanaud et al. (Infection Control and Hospital Epidemiology (1993) 14, 452-453) suggested that hospital foodhandlers should be screened routinely for intestinal parasites is challenged. The authors state that routine parasitological examination would not be cost effective, would not detect or prevent most acute infections, would not prevent most foodborne outbreaks and is therefore not recommended. Instead, it is suggested that routine education and training in good personal hygiene is more likely to be beneficial.
KW - disease transmission
KW - epidemiology
KW - food handlers
KW - food handling
KW - food hygiene
KW - health education
KW - helminthoses
KW - helminths
KW - hospitals
KW - human diseases
KW - parasites
KW - protozoal infections
KW - transmission
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - parasitic worms
KW - protozoal diseases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940803854&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human dietary responses to perceived manipulation of fat content in a midday meal.
AU - Caputo, F. A.
AU - Mattes, R. D.
JO - International Journal of Obesity
JF - International Journal of Obesity
Y1 - 1993///
VL - 17
IS - 4
SP - 237
EP - 240
SN - 0307-0565
AD - Caputo, F. A.: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19941403406. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Dietary responses to manipulations of information about fat content of a midday meal provided to free-living subjects 18-30 years old (12 women, 6 men) was examined. Following a 1 week baseline period, subjects were told that the meal provided each day for three 12-day blocks supplied a greater, lesser or equal amount of fat than their customary midday meal. Daily intake was recorded. During the low-fat information period, subjects increased total daily intake of energy relative to the high-fat period, their energy derived from protein relative to baseline and energy derived from fat relative to all other periods. It is indicated that information about fat content of foods can influence food selection and should be considered when developing dietary interventions aimed at moderating fat intake.
KW - behaviour
KW - diet
KW - energy intake
KW - fats
KW - feeding behaviour
KW - food intake
KW - information
KW - intake
KW - nutrition
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - feeding behavior
KW - Animal Behaviour (LL300)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403406&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recreational physical activity and ten-year weight change in a US national cohort.
AU - Williamson, D. F.
AU - Madans, J.
AU - Anda, R. F.
AU - Kleinman, J. C.
AU - Kahn, H. S.
AU - Byers, T.
JO - International Journal of Obesity
JF - International Journal of Obesity
Y1 - 1993///
VL - 17
IS - 5
SP - 279
EP - 286
SN - 0307-0565
AD - Williamson, D. F.: Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30333, USA.
N1 - Accession Number: 19941403412. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Data from the First National Health and Nutrition Examination Survey (NHANES-1) Epidemiologic Follow-up Study (1971-1975 to 1982-1984) were used to examine the relation between self-reported recreational physical activity level (low, medium, high) and measured weight change after 10 years among 3515 men and 5810 women, 25-74 years old. Cross-sectional analyses at baseline and follow-up surveys revealed that recreational physical activity was inversely related to body weight. Low recreational physical activity reported at the follow-up survey was strongly related to major weight gain (>13 kg) that had occurred during the preceding 10 years. Estimated relative risk of major weight gain for those in the low activity level at the follow-up survey compared with those in the high activity level was 3.1 (95% confidence interval = 1.6-6.0) in men and 3.8 (2.3-6.5) in women. In addition, the relative risk for persons whose activity level was low at baseline and follow-up surveys was 2.3 (0.9-5.8) in men and 7.1 (2.2-23.3) in women. No relationship was found between baseline physical activity level and subsequent weight gain among men or women. This may be due to mis-specification of physical activity because of changes in activity over time. Findings suggest that low physical activity may be a cause and a consequence of weight gain.
KW - body weight
KW - obesity
KW - physical activity
KW - weight gain
KW - weight reduction
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941403412&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Carotene uptake, metabolism, and distribution in BALB/c 3T3 cells.
AU - Wamer, W. G.
AU - Wei, R. R.
AU - Matusik, J. E.
AU - Kornhauser, A.
AU - Dunkel, V. C.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1993///
VL - 19
IS - 1
SP - 31
EP - 41
SN - 0163-5581
AD - Wamer, W. G.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951408372. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 7235-40-7, 68-26-8. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Although a growing number of epidemiological studies indicate that dietary β-carotene has anticarcinogenic activity, the mechanism(s) of β-carotene protection remains to be definitively established. In this context, in vitro studies of β-carotene have been, and continue to be, valuable. The following critical features in designing an in vitro system for studying the protective action of β-carotene were examined: form of β-carotene used for cellular uptake, cellular metabolism of β-carotene, and subcellular distribution of β-carotene. β-Carotene added to medium in a water-dispersible formulation is readily taken up by BALB/c 3T3 cells and is located predominantly in cellular membranes. Cellular uptake of β-carotene added to medium in an organic solvent is greatly reduced. It was also found that intracellular retinol increased significantly after a 3-day exposure of BALB/c 3T3 cells to media containing β-carotene. This result suggests that the ability to metabolize β-carotene to retinoids is not limited to cells of intestinal origin. The results and methodology described here will be useful in the rational design of in vitro assays for elucidating the mechanism(s) of β-carotene protective effects at the cellular level.
KW - beta-carotene
KW - cell cultures
KW - distribution
KW - metabolism
KW - retinol
KW - uptake
KW - vitamins
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408372&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary carotenoids influenced biochemical but not morphological changes in adult male rats fed a choline-deficient diet.
AU - Jenkins, M. Y.
AU - Sheikh, N. M.
AU - Mitchell, G. V.
AU - Grundel, E.
AU - Blakely, S. R.
AU - Carter, C. J.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1993///
VL - 19
IS - 1
SP - 55
EP - 65
SN - 0163-5581
AD - Jenkins, M. Y.: Division of Nutrition, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951408370. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 514-78-3, 1406-18-4. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - In a study of the effects of carotenoids, canthaxanthin (CA), β-apo-8′-carotenal (BA), or β-carotene in an extract of Spirulina-Dunaliella algae (AE) was fed at 0, 0.1 or 0.2% in a choline-deficient (CD) diet. In each of 8 groups, 10 adult male Fischer 344 rats were fed on diets with designated carotenoid sources and levels or a choline-sufficient diet for 12 weeks. Carotenoids altered some of the changes induced by the CD diet. Increases in enlargement of fatty livers and low plasma cholesterol levels occurred in rats fed 0.2% BA. Plasma retinol was further reduced 35% by BA or AE. BA and AE increased liver total vitamin A about 80 and 305%, respectively. Liver lipid peroxidation was enhanced and plasma α-tocopherol was reduced further by 1.0% AE. AE, BA and CA (mg/g fat) depressed liver α-tocopherol about 49, 67 and 78%, respectively. The decreased liver α-tocopherol was concurrent with an increase in carotenoid stores of CA > BA > AE. Histopathological examination of sections of liver tissue by light microscopy showed fatty and cirrhotic changes in all rats fed CD diets. Histochemical evaluation based on a semiquantitative assay revealed a marked increase in peroxisome enzyme activity in the livers of all CD rats. None of the carotenoids seemed to have any effect on the development of morphological changes in the liver. Although carotenoids can function as antioxidants, they did not prevent changes observed in rats fed CD diets.
KW - antioxidants
KW - blood
KW - blood lipids
KW - canthaxanthin
KW - carotenoids
KW - fatty liver
KW - lipid peroxidation
KW - liver
KW - morphology
KW - vitamin E
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fatty liver disease
KW - fatty liver syndrome
KW - steatosis
KW - tetraterpenoids
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408370&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality of workers employed in shoe manufacturing.
AU - Walker, J. T.
AU - Bloom, T. F.
AU - Stern, F. B.
AU - Okun, A. H.
AU - Fingerhut, M. A.
AU - Halperin, W. E.
JO - Scandinavian Journal of Work, Environment & Health
JF - Scandinavian Journal of Work, Environment & Health
Y1 - 1993///
VL - 19
IS - 2
SP - 89
EP - 95
SN - 0355-3140
AD - Walker, J. T.: National Institute for Occupational Safety and Health, Robert A Taft Laboratories, R-42, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19942026230. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - A retrospective cohort mortality study was conducted [in Ohio, USA] among 7814 white shoe manufacturing workers followed from 1940 through 1982. The workers were potentially exposed to solvents (including toluene) and solvent-based adhesives. Benzene may have been present as an impurity of toluene. Mortality due to leukaemia and aleukaemia was not statistically significantly elevated. Statistically significant excess mortality due to cancer of the trachea, bronchus and lung was observed in the total cohort [standardized mortality ratio (SMR) 147, 95% confidence interval (95% CI) 120-180] and showed a statistically significant trend in standardized relative risk with increasing potential latency, but not with increasing duration of employment. Chronic non-malignant respiratory disease was significantly elevated among the men (SMR 158, 95% CI 114-217) but was less than expected among the women (SMR 79), a finding suggesting a possible contribution of smoking to the mortality from respiratory cancer. However, adjustment for the potential effects of smoking did not completely eliminate the increased risk for lung cancer. AS
KW - Mortality
KW - neoplasms
KW - Occupational disorders
KW - occupational hazards
KW - occupational health
KW - solvents
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - cancers
KW - death rate
KW - shoe workers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026230&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioassay for carcinogenicity of rotenone in female Wistar rats.
AU - Greenman, D. L.
AU - Allaben, W. T.
AU - Burger, G. T.
AU - Kodell, R. L.
JO - Fundamental and Applied Toxicology
JF - Fundamental and Applied Toxicology
Y1 - 1993///
VL - 20
IS - 3
SP - 383
EP - 390
SN - 0272-0590
AD - Greenman, D. L.: National Center for Toxicological Research, Office of Scientific Coordination, HFT-30, Jefferson, AR 72079, USA.
N1 - Accession Number: 19950502916. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 67-66-3, 83-79-4. Subject Subsets: Botanical Pesticides
N2 - Rotenone, a pesticide extracted from the Derris root, consistently was reported by a series of investigators to have induced mammary fibroadenomas in female Wistar rats when administered ip or by gavage in a sunflower (SF) oil or SF oil: chloroform vehicle. In contrast, no less than 8 bioassays done in other laboratories with rotenone or rotenone-containing powders have given consistently negative carcinogenic results when different strains or species and different models or vehicles of administration have been used. However, these studies were not designed to address the biological reproducibility of the positive data. Thus,the present study was designated to simulate conditions of the positive studies and to investigate a possible co-carcinogenic interaction between rotenone and chloroform. Each of 8 treatment groups was assigned 72 weanling female Wistar rats. Groups were (1) untreated, (2) needle puncture, (3) SF oil:10% chloroform (SF oil:chloroform), (4) 1.0 mg/kg rotenone in SF oil:chloroform, (5) 2.0 mg/kg rotenone in SF oil:chloroform, (6) SF oil, (7) 1.0 mg/kg rotenone in SF oil, and (8) 2.0 mg/kg rotenone in SF oil. Rats were injected ip 5 days a week for 8 weeks (42 injection days) and subsequently held for 16 months. The appearance of palpable tissue masses was recorded; over 50 tissues from each rat were histologically evaluated. There were no statistically significant differences in overall or individual tumour incidences among control and rotenone-treated groups. Specifically, neither incidence nor time-to-palpation of mammary fibroadenoma significantly differed among control and rotenone-treated groups, regardless of the vehicle of administration. Thus, rotenone was not carcinogenic, and rotenone and chloroform did not interact to produce a carcinogenic effect in female Wistar rats in the current study. Thus, previous reports of carcinogenic activity were not reproducible under similar experimental conditions.
KW - bioassays
KW - carcinogenesis
KW - chloroform
KW - insecticides
KW - laboratory animals
KW - rotenone
KW - toxicology
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502916&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nucleotide sequence analysis of the ribosomal S12 gene of Mycobacterium intracellulare.
AU - Nair, J.
AU - Rouse, D.
AU - Morris, S.
JO - Nucleic Acids Research
JF - Nucleic Acids Research
Y1 - 1993///
VL - 21
IS - 4
SP - 1039
EP - 1039
SN - 0305-1048
AD - Nair, J.: (S. Morris) Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19932021648. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - DNA sequencing
KW - genes
KW - Mycobacterium
KW - Mycobacterium intracellulare
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterium
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - ribosomal S12
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Particle beam liquid chromatography/mass spectrometry with negative ion chemical ionization for the confirmation of ivermectin residue in bovine milk and liver.
AU - Heller, D. N.
AU - Schenck, F. J.
JO - Biological Mass Spectrometry
JF - Biological Mass Spectrometry
Y1 - 1993///
VL - 22
IS - 3
SP - 184
EP - 193
SN - 1052-9306
AD - Heller, D. N.: Food and Drug Administration, Center for Veterinary Medicine, Office of Science, Beltsville, MD 20705, USA.
N1 - Accession Number: 19950803078. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 70288-86-7. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Helminthology; Veterinary Science; Dairy Science
N2 - Particle beam liquid chromatography/mass spectrometry (LC/MS) using negative ion chemical ionization was applied to the analysis of ivermectin residues in bovine milk and liver. Samples were prepared by liquid/liquid extraction followed by alumina B solid-phase extraction clean-up. On-line LC/MS of extracts was carried out on a C-18 bonded silica column. Signals were observed from on-column injections of 4 ng dihydro-avermectin B1a (H2B1a) in extracts equivalent to 2 ml milk or 0.3 g liver. The specificity required for a regulatory confirmation procedure was achieved by monitoring the H2B1a molecular ion and 4 fragment ions. Ion chromatogram peak areas were at least 3 times greater than control samples integrated over the same time window. Co-eluting matrix compounds enhanced the response and altered the abundance pattern of H2B1a. To compensate for this matrix effect, control milk extracts were spiked with H2B1a, standard and used for the abundance matching requirement of regulatory confirmation.
KW - anthelmintics
KW - chromatography
KW - cows
KW - detection
KW - determination
KW - drug residues
KW - helminths
KW - ivermectin
KW - liquid chromatography
KW - liver
KW - mass spectrometry
KW - milk
KW - parasites
KW - residues
KW - techniques
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803078&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Q fever: prevalence of antibodies to Coxiella burnetii in the Basque Country.
AU - Sanzo, J. M.
AU - Garcia-Calabuig, M. A.
AU - Audicana, A.
AU - Dehesa, V.
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Y1 - 1993///
VL - 22
IS - 6
SP - 1183
EP - 1188
SN - 0300-5771
AD - Sanzo, J. M.: Epidemiology Unit, Public Health Service of Donostia, Basque Government, Bilbao, Spain.
N1 - Accession Number: 19940501176. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 308067-58-5. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Public Health
N2 - A study was conducted to ascertain the prevalence of C. burnetii infection in the Basque population of northern Spain. A stratified sampling was carried out (between November 1990 and October 1991), taking as a criterion the size of the population in a given area of residence. Residents in sparsely populated areas were found to have a prevalence of 38.5%, significantly greater than in highly populated areas (odds ratio (OR) = 1.56; 95% confidence interval (CI): 1.08-2.27 and OR = 1.58; 95% CI: 1.09-2.30). The prevalence was significantly higher in males (36.3%) than in females (29%), and was found to increase significantly with age. Current or previous participation in activities relating to agriculture and/or livestock farming or even having contact with cattle, goats or sheep were also found to be risk factors for the infection. A fuller study of the determinants of chronic Q fever in the Basque region needs to be initiated.<new para>ADDITIONAL ABSTRACT:<new para>The aim of this study was to ascertain the prevalence of Coxiella burnetii infection in the Basque population. To this end a stratified sampling was carried out taking as a criterion the size of the population in a given area of residence. Residents in sparsely populated areas were found to have a prevalence of 38.5%, significantly greater than in highly populated areas (odds ratio [OR] = 1.56; 95% confidence interval [CI]: 1.08-2.27 and OR = 1.58; 95% CI: 1.09-2.30). The prevalence was significantly higher in males (36.3%) than in females (29%), and was found to increase significantly with age. Current or previous participation in activities relating to agriculture and/or livestock farming or even having contact with cattle, goats or sheep were also found to be risk factors for the infection. A fuller study of the determinants of chronic Q fever should be initiated.AS
KW - antibodies
KW - epidemiology
KW - human diseases
KW - IgG
KW - Q fever
KW - rickettsial diseases
KW - serological surveys
KW - zoonoses
KW - Europe
KW - Spain
KW - Coxiella
KW - Coxiella burnetii
KW - man
KW - Coxiellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Coxiella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - abattoir fever
KW - bacterium
KW - Balkan grippe
KW - Basque Country
KW - Derrick-Burnet disease
KW - Nine Mile fever
KW - pneumorickettsiosis
KW - quadrilateral fever
KW - query fever
KW - seroepidemiology
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition knowledge levels about dietary fats and cholesterol: 1983-1988.
AU - Levy, A. S.
AU - Fein, S. B.
AU - Stephenson, M.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1993///
VL - 25
IS - 2
SP - 60
EP - 66
SN - 0022-3182
AD - Levy, A. S.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951407221. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 11 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
KW - cholesterol
KW - fats
KW - history
KW - nutrition knowledge
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951407221&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of fumonisin B1 in corn by high performance liquid chromatography with fluorescence detection.
AU - Ware, G. M.
AU - Francis, O.
AU - Kuan, S. S.
AU - Umrigar, P.
AU - Carman, A.
AU - Carter, L.
AU - Bennett, G. A.
JO - Analytical Letters
JF - Analytical Letters
Y1 - 1993///
VL - 26
IS - 8
SP - 1751
EP - 1770
SN - 0003-2719
AD - Ware, G. M.: Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122, USA.
N1 - Accession Number: 19931215104. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition; Maize; Postharvest Research
N2 - A method for the determination of fumonisin B1 in maize is described. After sample extraction with methanol:water (75:25) and partial purification with solid phase extraction, fumonisin B1 is reacted with naphthalene-2,3-dicarboxaldehyde to produce a highly fluorescent derivative which is quantitated by fluorescence detection at 410 nm excitation and a 440 nm, long past emission filter. Mean recoveries of fumonisin B1, added to maize at 0.25-20.0 µg/g, were 88.1% with a coefficient of variation of 10.3%. Fast atom bombardment spectroscopy confirmed fumonisin B1 in maize samples.
KW - biodeterioration
KW - contamination
KW - determination
KW - estimation
KW - Fumonisins
KW - liquid chromatography
KW - maize
KW - Mycotoxins
KW - Techniques
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931215104&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparisons of nucleotide and deduced amino acid sequences of the glycoprotein genes of a Chinese street strain (CGX89-1) and a Chinese vaccine strain (3aG) of rabies virus.
AU - Bai, X. H.
AU - Warner, C. K.
AU - Fekadu, M.
JO - Virus Research
JF - Virus Research
Y1 - 1993///
VL - 27
IS - 2
SP - 101
EP - 112
SN - 0168-1702
AD - Bai, X. H.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942208060. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Veterinary Science; Veterinary Science; Agricultural Biotechnology
N2 - The complete glycoprotein gene sequences of the canine street strain CGX89-1 and the human vaccine 3aG each has 1575 nucleotides and encodes a polypeptide of 524 amino acids. The overall nucleotide homology of the glycoprotein genes is 84.5% and the deduced amino acid homology is 89.5%. 21% of the base changes result in amino acid substitutions. Comparison of the homologies of the glycoprotein genes showed that the most conserved region is the ectodomain, whereas the most variable regions are the transmembrane and cytoplasmic domains. The overall nucleotide homologies of the 3aG glycoprotein and the CGX89-1 glycoprotein compared with the Pasteur virus glycoprotein are 91.2% and 84.1%, respectively. The glycoprotein gene sequences, the first from isolates of Chinese origin, indicate the biological importance of this rabies gene.
KW - amino acids
KW - biotechnology
KW - glycoproteins
KW - nucleotide sequences
KW - strain differences
KW - vaccines
KW - viral diseases
KW - China
KW - dogs
KW - man
KW - rabies virus
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - DNA sequences
KW - People's Republic of China
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Localization of the azoreductase of Clostridium perfringens by immuno-electron microscopy.
AU - Rafii, F.
AU - Cerniglia, C. E.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 1993///
VL - 27
IS - 3
SP - 143
EP - 145
SN - 0343-8651
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.
N1 - Accession Number: 19931379972. Publication Type: Journal Article. Language: English. Number of References: 9 ref.
N2 - An antibody against Clostridium perfringens azoreductase was used with protein A (gold-labelled) to locate the site of synthesis of extracellular azoreductase in this bacterium. Electron microscopy of immunogold-stained thin sections of C. perfringens cells showed an average of 134 gold particles per cell, distributed throughout the cytoplasm and not associated with any organized structures.
KW - biodeterioration
KW - electron microscopy
KW - enzymes
KW - pathogens
KW - synthesis
KW - techniques
KW - bacteria
KW - Clostridium perfringens
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - azoreductase
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Women and AIDS.
AU - Segal, M.
JO - FDA Consumer
JF - FDA Consumer
Y1 - 1993///
VL - 27
IS - 8
SP - 8
EP - 14
SN - 0362-1332
AD - Segal, M.: Public Affairs Division, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19942025160. Publication Type: Journal Article. Language: English.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Clinical aspects
KW - Clinical trials
KW - Epidemiology
KW - HIV infections
KW - Prevention
KW - sociology
KW - Treatment
KW - Women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - clinical picture
KW - human immunodeficiency virus infections
KW - social aspects
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Women (UU500)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sex ratio and phoretic mites of fleas (Siphonaptera: Pulicidae and Hystrichopsyllidae) on the Nile grass rat (Arvicanthis niloticus) in Kenya.
AU - Schwan, T. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 122
EP - 135
SN - 0022-2585
AD - Schwan, T. G.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Arthropod-borne Diseases Section, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930515210. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The sex ratio of fleas and their phoretic mites associated with A. niloticus were studied during 14 months in a grassland community of Lake Nakuru National Park, Kenya. Females of the fleas Dinopsyllus lypusus, Ctenophthalmus calceatus cabrius and Xenopsylla cheopis bantorum infested more grass rats and in greater numbers than did males. Phoretic hypopi (heteromorphic deutonymphs) of 2 species of mites, Psylloglyphus uilenbergi and Paraceroglyphus xenopsylla, varied seasonally in their abundance on fleas and utilized female fleas over male fleas for their major source of transport. Additionally, the mites were very host specific with nearly 100% of those identified on D. lypusus and C. calceatus cabrius being Psylloglyphus uilenbergi and 89% of the mites identified on X. cheopis bantorum being Paraceroglyphus xenopsylla. This level of specificity suggests that these mite-flea associations are highly evolved. The importance of female fleas as hosts for transporting mites also suggests that female-biased sex ratios of fleas on their hosts may be caused, in part, by females being more important as dispersers within flea populations.
KW - Ecology
KW - Ectoparasites
KW - Hosts
KW - phoresy
KW - Population ecology
KW - Seasonality
KW - Sex ratio
KW - Small mammals
KW - Wild animals
KW - Africa
KW - Kenya
KW - Acari
KW - Acaridae
KW - Arachnida
KW - Arvicanthis niloticus
KW - Dinopsyllus
KW - Dinopsyllus lypusus
KW - Hystrichopsyllidae
KW - Muridae
KW - Pulicidae
KW - Rodents
KW - Siphonaptera
KW - WINTERSCHMIDTIIDAE
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Astigmata
KW - mites
KW - Acari
KW - Arvicanthis
KW - Murinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - Ctenophthalmus
KW - Hystrichopsyllidae
KW - Dinopsyllus
KW - Acaridae
KW - Winterschmidtiidae
KW - Xenopsylla cheopis
KW - Xenopsylla
KW - Pulicidae
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - Ctenophthalmus calceatus
KW - Ctenophthalmus calceatus cabrius
KW - Paraceroglyphus
KW - Paraceroglyphus xenopsylla
KW - Psylloglyphus
KW - Psylloglyphus uilenbergi
KW - Saproglyphidae
KW - Xenopsylla cheopis bantorum
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete, Borrelia burgdorferi.
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 199
EP - 203
SN - 0022-2585
AD - Piesman, J.: Medical Entomology-Ecology Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19930515217. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A standard system for infecting ticks with B. burgdorferi is defined. Rodents infected via tick feeding or inoculation of tick homogenates were more infectious to ticks than rodents infected with culture-derived spirochaetes. White laboratory mice were more infectious than hamsters. 3 strains of B. burgdorferi (JD1, B31 and WI210) produced batches of infected ticks with >80% infection when mice were infected with tick-derived material. I. dammini [I. scapularis] were 3.6× more efficient than I. pacificus in acquiring and maintaining infection with 2 Californian strains of B. burgdorferi, originally isolated from I. pacificus.
KW - Disease vectors
KW - infection
KW - Laboratory animals
KW - methodology
KW - Techniques
KW - Vector competence
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Hamsters
KW - Ixodes
KW - Ixodes pacificus
KW - Ixodes scapularis
KW - Ixodidae
KW - Mice
KW - Rodents
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - bacterium
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of Yersinia pestis infection on temperature preference and movement of the Oriental rat flea (Xenopsylla cheopis) (Siphonaptera: Pulicidae).
AU - Thomas, R. E.
AU - Karstens, R. H.
AU - Schwan, T. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 209
EP - 213
SN - 0022-2585
AD - Thomas, R. E.: Laboratory of Vectors and Pathogens, Arthropod-Borne Infectious Diseases Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, 903 South 4th Street, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930515219. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Previous laboratory studies have shown that inoculation of bacterial endotoxin into the haemocoel of some arthropods, or natural infection by a number of pathogens, causes them to seek out a higher ambient temperature. This phenomenon has been called 'behavioural fever'. Y. pestis is an endotoxin-producing bacterium that relies on infection of fleas for transmission. Behavioural fever in fleas might enhance the transmission of plague if infected fleas were induced to seek out a warm-bodied host after the death of an infected host. Studies indicate that in thermal gradients Y. pestis-infected fleas (X. cheopis) do not exhibit behavioural fever and in one experiment sought out a significantly lower temperature.
KW - Disease vectors
KW - Infections
KW - Temperature
KW - Enterobacteriaceae
KW - Pulicidae
KW - Siphonaptera
KW - Xenopsylla cheopis
KW - Yersinia pestis
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Xenopsylla
KW - Pulicidae
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - bacterium
KW - behavioural fever
KW - Oriental rat flea
KW - YERSINIA PSEUDOTUBERCULOSIS SUBSP. PESTIS
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Eastern equine encephalitis virus in Ohio during 1991.
AU - Nasci, R. S.
AU - Berry, R. L.
AU - Restifo, R. A.
AU - Parsons, M. A.
AU - Smith, G. C.
AU - Martin, D. A.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 217
EP - 222
SN - 0022-2585
AD - Nasci, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19930515221. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - During August and September of 1991, an epizootic of eastern equine encephalitis (EEE) virus in horses occurred in Wayne and Holmes counties, Ohio, USA. This was the first reported epizootic of EEE virus in the state. 12 horses were confirmed positive for EEE virus through virus isolation or seroconversion, and 7 additional horses with compatible symptoms were in close spatial and temporal proximity to the confirmed cases and were presumed to have died from EEE virus. The outbreak was centered around the Killbuck Wildlife Area, a 2147-ha tract maintained by the state, half of which consists of wooded swamp and marsh. Mosquitoes were collected in upland areas before the epizootic and in the swamp basin at the end of the epizootic to identify the mosquito species involved in EEE virus transmission. A total of 22 095 specimens was collected and tested for the presence of virus. EEE virus was isolated from 1 pool of the most likely epizootic vector, Coquillettidia perturbans. The minimum infection rate for EEE in this species was 0.1/1000. Dense populations of Aedes vexans and Culex salinarius occurred in the area, but their densities peaked after the epizootic. It is unlikely that these species were involved in epizootic transmission. IgM antibody to EEE virus was detected in 3 bird species (eastern wood peewee, song sparrow, downy woodpecker) collected in the swamp.
KW - Arboviruses
KW - Disease vectors
KW - epidemiology
KW - horse diseases
KW - Marshes
KW - Mosquito-borne diseases
KW - Serological surveys
KW - swamps
KW - Viral diseases
KW - wild animals
KW - Wild birds
KW - North America
KW - Ohio
KW - USA
KW - Aedes vexans
KW - Alphavirus
KW - Birds
KW - Coquillettidia perturbans
KW - Culex salinarius
KW - Culicidae
KW - Diptera
KW - eastern equine encephalitis virus
KW - Equine encephalomyelitis virus
KW - horses
KW - Togaviridae
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - vertebrates
KW - Chordata
KW - Coquillettidia
KW - Culex
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - America
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - East North Central States of USA
KW - arthropod-borne viruses
KW - marshlands
KW - mosquitoes
KW - seroepidemiology
KW - United States of America
KW - viral infections
KW - Wetlands (PP320)
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Susceptibility parameters of Aedes albopictus to per oral infection with eastern equine encephalitis virus.
AU - Mitchell, C. J.
AU - McLean, R. G.
AU - Nasci, R. S.
AU - Crans, W. J.
AU - Smith, G. C.
AU - Caccamise, D. F.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 233
EP - 235
SN - 0022-2585
AD - Mitchell, C. J.: Medical Entomology-Ecology Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19930515278. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Public Health
N2 - Aedes albopictus mosquitoes were fed on snowy egrets (Egretta thula) that had been infected by subcutaneous inoculation of eastern equine encephalitis (EEE) virus. Freshly fed mosquitoes were frozen and tested to determine how much virus they had ingested. Other fed mosquitoes from the same lots were incubated for 7 days at 27°C before testing. Seven lots of A. albopictus fed on viraemic birds. Based on average amounts of virus ingested and day 7 virus infection rates in mosquitoes from the same lots, the amount of virus required to infect 50% of the mosquitoes was calculated to be 102.8 Vero cell plaque-forming units (PFU). The infection threshold (i.e. the amount of virus required to infect from 1 to 5% of mosquitoes) was determined to be ≤10 PFU per blood meal. These parameters indicate that A. albopictus is sufficiently susceptible to infection with EEE virus to enable it to acquire infectious doses from a wide variety of viraemic birds and possibly from equines.
KW - Arboviruses
KW - Disease vectors
KW - infection
KW - susceptibility
KW - Vector competence
KW - Aedes
KW - Aedes albopictus
KW - Alphavirus
KW - Ardeidae
KW - Birds
KW - Culicidae
KW - Diptera
KW - eastern equine encephalitis virus
KW - Egretta thula
KW - Equine encephalomyelitis virus
KW - Togaviridae
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Ciconiiformes
KW - birds
KW - vertebrates
KW - Chordata
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Egretta
KW - Ardeidae
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - eastern equine encephalitis
KW - mosquitoes
KW - Aquatic Biology and Ecology (MM300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Arbovirus surveillance in northern Colorado, 1987 and 1991.
AU - Smith, G. C.
AU - Moore, C. G.
AU - et al.
AU - Davis, T. (
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1993///
VL - 30
IS - 1
SP - 257
EP - 261
SN - 0022-2585
AD - Smith, G. C.: Medical Entomology-Ecology Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19930515281. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Arbovirus surveillance was conducted during an epizootic of western equine encephalitis (WEE) during 1987 and during a non-epizootic year, 1991, in the same area in northern Colorado [USA]. Mosquitoes were collected in Larimer County, CO, during weeks 33-37 (10 August to 7 September) in 1987 and during weeks 26-35 (24 June to 26 August) in 1991. In total, 13 099 mosquitoes in 694 pools collected during 1987 and 8672 mosquitoes in 242 pools collected during 1991 were tested for virus. WEE virus was isolated in both years from Culex tarsalis Coquillet and from Cx. pipiens in 1987. Infection rates and population levels of Cx. tarsalis were not significantly different in the 2 years during weeks 33, 34 and 35 (12-26 August). St. Louis encephalitis virus was isolated in 1987 from Cx. tarsalis. Other viruses isolated included Hart Park, Turlock and Jerry Slough, a variety of Jamestown Canyon virus.\AS<new para>ADDITIONAL ABSTRACT:<new para>Arbovirus surveillance was conducted during an epizootic of western equine encephalitis (WEE) in 1987 and during a non-epizootic year, 1991, in the same area in northern Colorado, USA. Mosquitoes were collected in Larimer County, during weeks 33-37 (10 August to 7 September) in 1987 and during weeks 26-35 (24 June to 26 August) in 1991. In total, 13 099 mosquitoes in 694 pools collected during 1987 and 8672 mosquitoes in 242 pools collected during 1991 were tested for virus. WEE virus was isolated in both years from Culex tarsalis and from C. pipiens in 1987. Infection rates and population levels of C. tarsalis were not significantly different in the 2 years during weeks 33, 34 and 35 (12-26 August). St. Louis encephalitis virus was isolated in 1987 from C. tarsalis. Other viruses isolated included Hart Park, Turlock and Jerry Slough, a variety of Jamestown Canyon virus.
KW - Arboviruses
KW - Disease vectors
KW - epidemiology
KW - Mosquito-borne diseases
KW - Surveillance
KW - Colorado
KW - North America
KW - USA
KW - Alphavirus
KW - Culex
KW - Culex pipiens
KW - Culex tarsalis
KW - Culicidae
KW - Diptera
KW - Flavivirus
KW - Hart Park virus
KW - Jamestown Canyon virus
KW - Orthobunyavirus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Togaviridae
KW - Turlock virus
KW - Western equine encephalitis virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Flaviviridae
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - Flavivirus
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - America (North)
KW - arthropod-borne viruses
KW - Bunyavirus
KW - Jerry Slough virus
KW - mosquitoes
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liberian practices in feeding infants water, breastmilk and first food.
AU - Jarosz, L. A.
JO - Ecology of Food and Nutrition
JF - Ecology of Food and Nutrition
Y1 - 1993///
VL - 30
IS - 3/4
SP - 221
EP - 240
SN - 0367-0244
AD - Jarosz, L. A.: Department of Public Health Service, School of Public Health, University of Hawaii, Biomedical Science Building, Court D, 1960 East West Road, Honolulu, HI 96822, USA.
N1 - Accession Number: 19941411782. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition
N2 - Practices in feeding water, human milk and first food are described for 125 children ≤25 months old living in 4 geographic areas of Liberia, West Africa, in l980. Samples of 18-32 children represented 5 socioeconomic groups, 3 from rural areas and 2 from the urban capital, Monrovia. Diet was assessed using a method to reduce communication errors. Breast feeding initiation was earlier and duration greater in rural groups compared with urban groups. The average age for introducing food was 2.0 months, but it varied by group between 0.9 and 2.7 months. Non-milk foods were introduced before or simultaneously with milk-based foods in all groups except one which used milk-based food as human milk replacement. Delayed introduction of water and food in one group was due to a health clinic's educational efforts and not to inherent cultural differences. Food introduction was earlier than shown in 2 previous surveys. Practices made a perspective on infant feeding policy recommendations.
KW - breast feeding
KW - cows
KW - infant feeding
KW - infants
KW - milk
KW - water intake
KW - weaning
KW - Developing countries
KW - Liberia
KW - cattle
KW - man
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - countries
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - Third World
KW - Underdeveloped Countries
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Teratogenic potential of FD & C Red No. 3 when given in drinking water.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - O'Donnell, M. W., Jr.
AU - Shackelford, M. E.
AU - Bulhack, P.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1993///
VL - 31
IS - 3
SP - 161
EP - 167
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951406189. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - FD & C Red No. 3 (erythrosine), a commonly used food additive, was administered to pregnant Osborne-Mendel rats to study its teratogenic potential. Dosing solutions of 0.05, 0.1, 0.2 or 0.4% in distilled water were available at all times and corresponded to daily doses of 64, 121, 248 and 472 mg FD & C Red No. 3/kg body weight. Distilled water served as the control. On gestation day 20, the rats were killed and caesarean sections were performed. The treated rats consumed less fluid than did the control rats, but only random decreases were significant and no dose relationship was seen. Only the 0.2% group consumed significantly more feed than the controls during gestation. Maternal weight gain during days 0-20 was not significantly affected in any group. No dose-related changes were seen in maternal clinical findings, implantations, foetal viability, foetal size (weight and length) or visceral development. No dose-related teratogenesis was seen. Skeletal development was not affected; the few significant increases in skeletal variations were not dose related and were considered to be random. FD & C Red No. 3 was neither fetotoxic nor teratogenic at the dose levels tested in drinking water.
KW - drinking water
KW - food additives
KW - teratogenesis
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Additives (QQ130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of combined benzidine in FD & C Yellow No. 5 (tartrazine), using a highly sensitive analytical method.
AU - Prival, M. J.
AU - Peiperl, M. D.
AU - Bell, S. J.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1993///
VL - 31
IS - 10
SP - 751
EP - 758
SN - 0278-6915
AD - Prival, M. J.: Genetic Toxicology Branch (HFS-236), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951406245. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - 53 samples of FD & C Yellow No. 5 (tartrazine; Colour Index No. 19140) were examined for combined benzidine. These samples, which represent separate lots from 12 dye distributors, were submitted to the US FDA for certification between 28 February 1990 and 27 June 1991. A method was developed to reduce the dye matrix with dithionite so that combined benzidine present in the form of azo or disazo dyes would be converted to free benzidine. Reduction was followed by extraction, diazotization and coupling with pyrazolone T, and the total benzidine present was quantitated as benzidine-pyrazolone T disazo dye (BZPT) by HPLC with detection at 500 nm. The limit of quantitation for benzidine in FD & C Yellow No. 5 by this method is 5 ng/g. 25 samples of FD & C Yellow No. 5 were found to contain 7-83 ng/g of combined benzidine that was released by dithionite reduction. 23 of these samples were from the same manufacturer. The identity of the BZPT from two FD & C Yellow No. 5 samples was confirmed by spectral analysis using HPLC with a photodiode array detector.
KW - amines
KW - analytical methods
KW - carcinogens
KW - food additives
KW - food colourants
KW - analytical techniques
KW - food colorants
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406245&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Foetal development in rats fed AIN-76A diets supplemented with excess calcium.
AU - Shackelford, M. E.
AU - Collins, T. F. X.
AU - Welsh, J. J.
AU - Black, T. N.
AU - Ames, M. J.
AU - Chi, R. K.
AU - O'Donnell, M. W.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1993///
VL - 31
IS - 12
SP - 953
EP - 961
SN - 0278-6915
AD - Shackelford, M. E.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951406227. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The developmental effects of moderate dietary calcium increases in rats fed nutritionally adequate diets were examined. Female Charles River CD/VAF Plus rats were given 0.50 (control), 0.75, 1.00 or 1.25% dietary calcium as calcium carbonate in AIN-76A diets for 6 weeks before mating, during mating and for 20 days of gestation. On gestation day 20, the rats were killed and caesarean sections were performed. Non-pregnant and pregnant rats in the 0.75, 1.00 and 1.25% groups ate slightly more than did the control group during most of the intervals measured, but not all the increases were significant. There was no consistent pattern of increase or decrease in weight gain. No dose-related changes were found in maternal clinical findings, the average number of implantations, resorptions and viable fetuses, or fetal length or weight. Under the conditions of the study, there were no significant increases as compared with the control group in the litter incidence regarding specific external, visceral or skeletal variations of the fetuses. Dietary calcium was neither fetotoxic nor teratogenic at the concentrations used.
KW - calcium
KW - diet
KW - fetal development
KW - supplements
KW - teratogenesis
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951406227&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Excess hepatobiliary cancer mortality among munitions workers exposed to dinitrotoluene.
AU - Stayner, L. T.
AU - Dannenberg, A. L.
AU - Bloom, T.
AU - Thun, M.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1993///
VL - 35
IS - 3
SP - 291
EP - 296
SN - 0096-1736
AD - Stayner, L. T.: National Institute for Occupational Safety and Health (NIOSH), Mail Stop: C-15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19942025614. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - An analysis of the mortality experience of workers exposed to dinitrotoluene (DNT) was conducted to test the hypothesis that DNT exposure is associated with an increased risk of cancers of the liver and biliary tract. A total of 4989 workers exposed to DNT and 7436 unexposed workers who had worked for at least 5 months at the study facility [in the USA] between 1 January 1949 and 21 January 1980, were included in this investigation. Workers were considered exposed if they had worked at least 1 day on a job with probable exposure to DNT. The vital status as of 31 December 1982, was successfully ascertained for approximately 97% of these workers. ... An excess of hepatobiliary cancer was observed among workers exposed to DNT in this study. The rate ratio for hepatobiliary cancer was 2.67 (6 cases observed) based upon comparison with the US population (standardized mortality rate (SRR) = 2.67, 95% CI = 0.98, 5.83), and 3.88 based upon comparison using the internal unexposed referent group (standardized rate ratio (SRR) = 3.88, 95% CI = 1.04, 14.41). This study failed to demonstrate an exposure-response relationship between duration of DNT exposure and hepatobiliary cancer mortality. ... On balance, [the authors] believe that [their] findings add some support for the hypothesis that occupational exposure to DNT may be carcinogenic. AS
KW - mortality
KW - neoplasms
KW - occupational medicine
KW - Occupations
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - cancers
KW - death rate
KW - dinitrotoluene
KW - munitions workers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025614&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Symposium. Microbiological significance of drug residues in food. June 8-9, 1992, Rockville, Maryland.
T2 - Veterinary and Human Toxicology
JO - Veterinary and Human Toxicology
JF - Veterinary and Human Toxicology
Y1 - 1993///
VL - 35
IS - SUPP 1
SP - 1
EP - 48
SN - 0145-6296
AD - Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19952200087. Publication Type: Conference proceedings. Corporate Author: FDA Center for Veterinary Medicine.; Animal Health Institute Foundation. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Veterinary Science
N2 - Two papers discuss regulation of antimicrobial residues, and 4 papers cover the normal human intestinal flora, perturbation of human intestinal flora, clinical and public health concerns for antibiotic resistance in human intestinal microflora, and studies to measure the effect of antibiotic resistance in man. Two papers discuss the microbiological significance of drug residues in food, and one describes the status of models for testing antibiotic residues. There were 2 panel discussions: one concerned with microbial testing necessary for New Animal Drug Approval; and the other on conditions for regulating antimicrobial residues.
KW - antibiotics
KW - drug residues
KW - drug resistance
KW - intestinal microorganisms
KW - legislation
KW - models
KW - public health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - gut flora
KW - intestinal micro-organisms
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952200087&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heliophysical activity and incidence variations of skin malignant melanoma in Czechoslovakia: a regional study.
AU - Dimitrov, B. D.
JO - International Journal of Biometeorology
JF - International Journal of Biometeorology
Y1 - 1993///
VL - 37
IS - 2
SP - 68
EP - 71
SN - 0020-7128
AD - Dimitrov, B. D.: Division of Public Health and Biostatistics, Department of Social Medicine and Public Health Service, Medical University, 11 "Armeiska" str., Stara Zagora 6000, Bulgaria.
N1 - Accession Number: 19932023294. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Cyclic variations in the incidence of skin malignant melanoma during the years 1964-1985 in East Bohemia (excluding the districts of Pardubice and Svitavy), Czechoslovakia have been studied, as linear correlations with solar activity indexes have been revealed. The following statistical methods were applied: periodogram regression analysis, phase-correlation analysis, sigma-method and Student's t-test. The discretization of the data is on the basis of 1 year. Different cycles were found in the incidence variations (T = 7.5 years, T = 11.5 years, etc.), and this has been correlated with the variations of two heliophysical indexes (Σ, W) for the same time period. A few significant statistical relationships have been established with a time difference (lag-period) between the extremes of the data series; the incidence maxima follow the peaks of solar activity and appear about the minima of solar indexes, mainly. AS
KW - epidemiology
KW - neoplasms
KW - skin
KW - Czechoslovakia
KW - Europe
KW - Central Europe
KW - Europe
KW - cancer sites
KW - cancers
KW - dermis
KW - solar activity
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023294&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Single-radial-immunodiffusion as an in vitro potency assay for human inactivated viral vaccines.
AU - Williams, M. S.
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 1993///
VL - 37
IS - 3/4
SP - 253
EP - 262
SN - 0378-1135
AD - Williams, M. S.: Laboratory of Respiratory Viruses, Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19942201722. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science
N2 - Single-radial-immunodiffusion (SRID) assays have been used to determine the potency of all human inactivated influenza virus vaccines licensed by the Food and Drug Administration for use in the United States since 1978. SRID replaced less reliable tests which were based on the aggregation of erythrocytes by the haemagglutinins of influenza viruses. Similar SRID assays have been used experimentally to determine the potency of inactivated polio and rabies vaccines. In each case, the assays are based on the diffusion of viral antigen into an agarose gel containing specific antibodies to the antigen being measured. For influenza and rabies, disruption of the virions with a detergent is necessary to permit the diffusion of the appropriate antigens, where as with polio, intact virions are allowed to diffuse. The interaction between antigen and antibody produces a zone of precipitation whose size is directly proportional to the amount of antigen applied. A potency value for unknowns is obtained by comparing the sizes of zones produced by unknown preparations to the sizes of zones obtained with a calibrated reference of known antigen content. Once the specific reference antigens and antibodies are prepared and the test standardized, it is a remarkably simple technique which unlike agglutination assays is very reproducible, relatively unaffected by minor variations in test conditions and is far less time consuming and cumbersome than in vivo assays for potency such as those done by inoculating mice or monkeys. More importantly, clinical studies demonstrate that standardization of influenza vaccines by SRID provides a better correlate of human immunogenicity than previous methods.
KW - immunodiffusion
KW - inactivated vaccines
KW - influenza viruses
KW - quality controls
KW - rabies
KW - viral diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - influenzavirus
KW - killed vaccines
KW - quality assurance
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942201722&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunogens of encephalitis viruses.
AU - Roehrig, J. T.
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 1993///
VL - 37
IS - 3/4
SP - 273
EP - 284
SN - 0378-1135
AD - Roehrig, J. T.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19942201724. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - The equine encephalitis viruses are members of the genus Alphavirus, in the family Togaviridae. Three main virus serogroups represented by western (WEE), eastern (EEE) and Venezuelan equine encephalitis (VEE) viruses cause epizootic and enzootic infection of horses throughout the western hemisphere. All equine encephalitis viruses are transmitted through the bite of an infected mosquito. The first equine encephalitis virus vaccines wer produced by virus inactivation. Problems with inadequate inactivation, which may have caused a major epidemic/epizootic of VEE in central America and Texas in the 1970s led to the development of a live attenuated VEE virus vaccine (TC-83) derived by cell culture passage. Inactivated vaccines are still used to prevent equine infections with WEE and EEE viruses. Alphaviruses are small single stranded, positive sense RNA viruses.The 12000 nucleotide genome is enclosed in an icosahedral nucleocapsid composed of multiple copies of the capsid (C) protein. The virion is enveloped. The membrane is modified by the insertion of heterodimers of two glycoproteins: E1 and E2. Monoclonal antibody analysis of the surface glycoproteins have provided a detailed understanding of important protective antigens. Recent studies comparing gene sequences from virulent and avirulent VEE viruses have begun to delineate mechanisms of alphavirus attenuation.
KW - disease prevention
KW - horse diseases
KW - immune response
KW - inactivated vaccines
KW - live vaccines
KW - reviews
KW - alphavirus
KW - eastern equine encephalitis virus
KW - equine encephalomyelitis virus
KW - horses
KW - Togaviridae
KW - Venezuelan equine encephalitis virus
KW - western equine encephalitis virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - attenuated vaccines
KW - immunity reactions
KW - immunological reactions
KW - killed vaccines
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942201724&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection.
AU - Erdman, D. D.
AU - Heath, J. L.
AU - Watson, J. C.
AU - Markowitz, L. E.
AU - Bellini, W. J.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 1993///
VL - 41
IS - 1
SP - 44
EP - 48
SN - 0146-6615
AD - Erdman, D. D.: Respiratory and Enterovirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942050856. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The use of IgM antibody detection for the classification of the primary and secondary measles antibody response in persons following primary and secondary vaccination and natural measles virus infection was examined. Of 32 nonimmune children receiving primary measles vaccination, 31 (97%) developed IgM antibodies, consistent with a primary antibody response. Of 21 previously vaccinated children with low levels of preexisting IgG antibodies who responded to revaccination, none developed detectable IgM antibodies, whereas 33 of 35 (94%) with no detectable preexisting IgG antibodies developed an IgM response. Of a sample of 57 measles cases with a prior history of vaccination, 55 (96%) had detectable IgM antibodies. Of these, 30 (55%) were classified as having primary antibody response and 25 (45%) a secondary antibody response based on differences in their ratios of IgM to IgG antibodies. Differences in the severity of clinical symptoms between these 2 groups were consistent with this classification scheme. These findings suggest that (1) an IgM response follows primary measles vaccination in the immunologically naive, (2) an IgM response is absent on revaccination of those previously immunized, and (3) an IgM response may follow clinical measles virus infection independent of prior immunization status.
KW - antibodies
KW - children
KW - immunization
KW - measles
KW - vaccines
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - immune sensitization
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Automated affinity liquid chromatography system for on-line isolation, separation, and quantitation of aflatoxins in methanol-water extracts of corn or peanuts.
AU - Urano, T.
AU - Trucksess, M. W.
AU - Page, S. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1993///
VL - 41
IS - 11
SP - 1982
EP - 1985
SN - 0021-8561
AD - Urano, T.: Division of Natural Products, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941412120. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Maize; Medical & Veterinary Mycology
N2 - An automated liquid chromatography (LC) procedure was developed for the determination of aflatoxins in maize and peanuts. The automated LC system consists of the following: 2 pumps, an autosampler, an isolation column (immunoaffinity or methacrylate copolymer), an automated switching valve, a C18 column, an electrochemical cell, a fluorescence detector and a data system. Filtered methanol:water (75:25) extracts of the test portions are injected into the LC system. With the switch in position 1, water is pumped through the autosampler and isolation column and then discarded. With the switch in position 2, the mobile phase consisting of methanol:acetonitrile:water (26:18:56), 1 mM KBr, and 1 mM HNO3 is pumped through the isolation column, C18 column, electrochemical cell and detector. Aflatoxins B1 and G1 react with electrochemically generated bromine to form fluorescent derivatives. Both isolation columns can be used for >50 injections. Recovery of aflatoxins from both commodities spiked at 5-30 ng/g was about 85%.
KW - aflatoxins
KW - analytical methods
KW - contamination
KW - estimation
KW - groundnuts
KW - liquid chromatography
KW - maize
KW - mycotoxins
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - analytical techniques
KW - corn
KW - fungal toxins
KW - peanuts
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412120&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic/matrix isolation/fourier transform infrared spectroscopic determination of trans-monounsaturated and saturated fatty acid methyl esters in partially hydrogenated menhaden oil.
AU - Mossoba, M. M.
AU - McDonald, R. E.
AU - Prosser, A. R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1993///
VL - 41
IS - 11
SP - 1998
EP - 2002
SN - 0021-8561
AD - Mossoba, M. M.: Division of General Scientific Support, Office of Scientific Analysis and Support, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941412122. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Elaidic acid (t-18:1) has been the focus of debate about its effect on blood cholesterol levels. A method is presented that can accurately quantify the level of (t-18:1), a single geometric isomer, in hydrogenated menhaden oil. Fatty acid methyl esters (FAMEs) were determined by Fourier transform infrared spectroscopy. The t-18:1 FAME and related trans-monounsaturated and saturated compounds were quantitated by linear regression analysis from the intensities of the 971- and 1121-cm-1 infrared bands, respectively. The 971-cm-1 band is produced for trans geometric isomers only; thus, interference from cis isomers, due to GC peak overlap, is eliminated. At an iodine value of 78, the t-18:1 composition of hydrogenated menhaden oil was 2.6% by weight. The use of internal standards was essential for quantitation. Satisfactory repeatability was achieved for quantitation of FAMEs from duplicate HPLC fractions; the t-18:1 FAME weight percent varied by 7.4%.
KW - analytical methods
KW - fatty acid esters
KW - fatty acids
KW - fish oils
KW - monoenoic fatty acids
KW - saturated fatty acids
KW - analytical techniques
KW - monounsaturated fatty acids
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412122&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of race and ethnicity in public health surveillance: summary of the CDC/ATSDR workshop.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1993///
VL - 42
IS - RR-10
SP - 1
EP - 17
SN - 0149-2195
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19932023190. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Public Health
N2 - This report gives the background to the issue and summarizes the presentations made and conclusions reached at a workshop held in Atlanta, Georgia, in March 1993. The objectives were to describe current measures of race and ethnicity and their use in public health surveillance, to assess the epidemiological basis thereof, and to propose better use of existing measures or identify alternatives. Recommendations for concepts, measures and uses are made, including the establishment of definitions, a focus on subgroups, the use of Hispanic as a race category, review and evaluation of definition, a classification noted for people of mixed racial and ethnic backgrounds, the adaption of years of education completed as the best and most practical measure of socioeconomic status in surveillance, and the collection of data for the improvement of public health. D.W. FitzSimons
KW - Community health
KW - ethnic groups
KW - ethnicity
KW - surveillance
KW - workshops
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - ethnic differences
KW - race and ethnicity use in public health surveillance
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
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DB - lhh
ER -
TY - GEN
T1 - Recommendations for use of Haemophilus b conjugate vaccines and a combined diphtheria, tetanus, pertussis, and Haemophilus b vaccine.
AU - Zangwill, K. M.
AU - Wenger, J. D.
AU - Sutter, R. W.
AU - Hadler, S. C.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1993///
VL - 42
IS - RR-13
SP - iv + 15
EP - iv + 15
SN - 0149-2195
AD - Zangwill, K. M.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19942025224. Publication Type: Miscellaneous. Language: English. Subject Subsets: Public Health
N2 - This document sets out the recommendations for the use of Haemophilus influenzae b (Hib) vaccines and combined Hib and diphtheria-tetanus-pertussis (DTP) vaccine in the USA. It begins with a description of the four types of Hib vaccine (PRP-OMP, PRP-D, PRP-T, HbOC) licensed in the USA. (Of these, all except PRP-D are also licensed in the UK.) The data available on the immunogenicity and efficacy of the Hib vaccines are summarized, as is information available on the safety and immunogenicity of the Hib-DTP combination Tetramune. No efficacy data are currently available on Tetramune but its properties are expected to resemble those of the DTP and Hib components. The contraindications and precautions to be taken with this are also the same as for DTP and Hib given as separate injections. It is noted that safety data support the concurrent administration of DTP Hib vaccines with oral polio and hepatitis B vaccines to infants and with concurrent administration of Hib, DTP, oral polio, measles, mumps and rubella vaccines to children 12-18 months old. The document notes the limited availability of information on the interchangeability of the various types of Hib vaccine given in the 2, 4, 6-month USA schedule. A first dose of PRP-OMP at 2 months followed by either PRP-T or HbOC at 4 months and 6 months has been found to give an adequate anti-PRP response. The sequence HbOC, PRP-T, PRP-T has also been found satisfactory. It seems likely that any combination of three doses of Hib conjugate will give adequate responses. It is also suggested that only two doses of PRP-OMP at 2 and 6 months will suffice for primary immunization. [However, it should be noted that unlike the UK, the USA schedule recommends booster doses for all the Hib conjugates at 12-14 and 15-59 months.] The range of mostly minor adverse reactions expected from the Hib vaccines and Tetramune and the contraindications and precautions to be taken are summarized. [This is a useful document for providing an introduction to the use of Hib vaccines and DTP combinations although the recommended schedules will not be applicable to many countries.] M.J. Corbel
KW - Diphtheria pertussis tetanus vaccines
KW - guidelines
KW - immunization
KW - infants
KW - vaccines
KW - Haemophilus influenzae type b
KW - man
KW - Haemophilus influenzae
KW - Haemophilus
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immune sensitization
KW - recommendations
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Special focus: behavioral risk factor surveillance-United States, 1991.
AU - Siegel, P. Z.
AU - Frazier, E. L.
AU - Mariolis, P.
AU - Brackbill, R. M.
AU - Smith, C.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1993///
VL - 42
IS - SS-4
SP - iii + 30
EP - iii + 30
SN - 0149-2195
AD - Siegel, P. Z.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19942025225. Publication Type: Miscellaneous. Corporate Author: USA, State Coordinators for the Behavioral Risk Factor Surveillance System Language: English. Registry Number: 57-88-5.
N2 - Risk reduction is a major focus of the US national health objectives for the year 2000. Progress toward several of these objectives can be evaluated by use of data from the Behavioural Risk Factor Surveillance System (BRFSS); these include those for overweight, lack of physical activity, smoking, safety belt use, and medical screening for breast and cervical cancer and elevated blood cholesterol. Such data have been used to guide health promotion/disease prevention programme, in the USA. This report gives a comprehensive description of the data for 1991, collected by a state-based random-digit-dialing telephone survey of non-institutionalized adults (≥18 years of age) in 47 states and the District of Columbia. Some year 2000 objectives appear to be readily attainable for many states, whereas others do not. For example, among participating states, a median 57.8% (range 45.6-82.8%) of women ages ≥50 years reported having had both a clinical breast examination and a mammogram in the previous 2 years (year 2000 objective: ≥60%). In contrast, a median 37.3% (range 22.1-52.5%) of persons with annual family income <$20 000 reported that they did not engage in leisure-time physical activity-more than twice the year 2000 objective (≥17%). These data demonstrate substantial state-to-state variation in progress toward year 2000 objectives and highlight areas (e.g. lack of leisure-time physical activity) in which substantial progress remains to be made in most states.
KW - cervical cancer
KW - cervix
KW - cholesterol
KW - disease prevention
KW - health care
KW - human diseases
KW - neoplasms
KW - physical activity
KW - risk factors
KW - risk reduction
KW - safety
KW - screening
KW - surveillance
KW - women
KW - District of Columbia
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - programmes
KW - screening tests
KW - telephone surveys
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Non-communicable Human Diseases and Injuries (VV600)
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DB - lhh
ER -
TY - JOUR
T1 - Surveillance for waterborne disease outbreaks - United States, 1991-1992.
AU - Moore, A. C.
AU - Herwaldt, B. L.
AU - Craun, G. F.
AU - Calderon, R. L.
AU - Highsmith, A. K.
AU - Juranek, D. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1993///
VL - 42
IS - SS-5
SP - 1
EP - 22
SN - 0149-2195
AD - Moore, A. C.: Parasitic Diseases Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19940805801. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 7732-18-5. Subject Subsets: Leisure, Recreation, Tourism; Protozoology; Helminthology; Public Health
N2 - During the 2 year period January 1991-December 1992, 17 USA states and territories reported 34 disease outbreaks associated with drinking water and affecting 17 464 people. Protozoa were implicated in 7 of the 11 outbreaks for which an agent was determined: Giardia lamblia [G. duodenalis], 4 outbreaks; Cryptosporidium, 3 outbreaks. 5 of these outbreaks were associated with a surface-influenced groundwater source and one outbreak of cryptosporidiosis was associated with filtered and chlorinated surface water. Shigella sonnei and hepatitis A virus were implicated in one outbreak each, both were linked to the consumption of contaminated well water. Two outbreaks were due to acute chemical poisoning. No aetiology was established for 23 (68%) of the 34 outbreaks, including the largest one reported during this period in which 9874 people using a filtered surface water supply developed gastroenteritis. Most of the 34 outbreaks were associated with a well water source. 21 states reported 39 outbreaks associated with recreational water and affecting an estimated 1825 people. Most frequently reported was hot tub- or whirlpool-associated Pseudomonas dermatitis (12 out of 13 Pseudomonas outbreaks). 4 outbreaks of swimming-associated gastroenteritis were caused by Giardia and 2 by Cryptosporidium, including 3 outbreaks associated with chlorinated, filtered pool water. The first reported outbreak of Escherichia coli infection associated with recreational exposure occurred during this period. Primary amoebic meningoencephalitis, caused by Naegleria fowleri infection, resulted in 6 deaths and 3 outbreaks were consistent with schistosomal dermatitis, 1 with Leptospira, 3 with Legionella, 2 with Shigella sonnei, 1 with adenovirus 3, the aetiology of the remaining outbreaks was unknown.
KW - aetiology
KW - drinking water
KW - groundwater
KW - helminths
KW - human diseases
KW - parasites
KW - polluted water
KW - surface water
KW - surveillance
KW - water
KW - water quality
KW - water recreation
KW - waterborne diseases
KW - North America
KW - USA
KW - Adenoviridae
KW - Apicomplexa
KW - Cryptosporidiidae
KW - Escherichia coli
KW - Hexamitidae
KW - Legionella
KW - Leptospira
KW - Naegleria fowleri
KW - protozoa
KW - Pseudomonas
KW - Sarcomastigophora
KW - Schistosomatidae
KW - Shigella sonnei
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Eucoccidiorida
KW - Apicomplexa
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Diplomonadida
KW - Sarcomastigophora
KW - Legionellaceae
KW - Legionellales
KW - Leptospiraceae
KW - Spirochaetales
KW - Spirochaetes
KW - Naegleria
KW - Vahlkampfiidae
KW - Schizopyrenida
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - Shigella
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - causal agents
KW - E. coli
KW - etiology
KW - parasitic worms
KW - Schizopyrenidae
KW - United States of America
KW - water composition and quality
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
KW - Recreation and Sport (UU620) (Discontinued March 2000)
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunization of dogs with Q fever vaccines: comparison of phase I, II and phase I CMR Coxiella burnetii vaccines.
AU - Williams, J. C.
AU - Peacock, M. G.
AU - Race, R. E.
JO - Revue d'Élevage et de Médecine Vétérinaire des Pays Tropicaux
JF - Revue d'Élevage et de Médecine Vétérinaire des Pays Tropicaux
Y1 - 1993///
VL - 46
IS - 1/2
SP - 87
EP - 94
SN - 0035-1865
AD - Williams, J. C.: FDA Center for Biologics Evaluation and Research, Bacterial Vaccine and Allergenic Products Branch, HFM-481 Woodmont 400N, 1401 Rockville Pike, Rockville, MD 20852-9090, USA.
N1 - Accession Number: 19942213674. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 23 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - Q fever vaccines were tested in mixed breed dogs by vaccinating them with formalin-killed C. burnetii whole cells (WC) in either phase I (WCI) or phase II (WCII), or the chloroform:methanol residue (CMR) subunit of phase I cells. Phase I vaccines mixed (1:1) with Freund's incomplete adjuvant (FIA) induced humoral immune responses to phases I and II antigens as measured by microagglutination assay. The CMR vaccine mixed (1:1) with FIA induced greater antigen-specific antibody levels to both phases I and II antigens than the corresponding WCI vaccine. The WCII vaccine induced antibody responses only to phase II antigens. The time course of erythema and induration after skin testing with C. burnetii antigens were suggestive of cell-mediated immunity (CMI). Although granulomas were observed with only WCI and WCII, none of the skin test antigens induced abscesses at the injection site. In contrast, axillary nodes draining the vaccine injection site developed sterile draining abscesses in all dogs by days 19 to 24 for the WCI and CMR, and day 104 for the WCII vaccines. The abscesses had resolved within 30 days after first appearance. Responses to Con A and PHA and recall antigens of lymphocytes from the blood, ancillary and mesenteric nodes, and spleen at 222 days after vaccination were variable among dogs. Lymphocytes from various organs responded to one or more of the recall antigens and to both mitogens in the absence or presence of indomethacin. Although these Q fever vaccines induced humoral immunity and CMI, either the antigens or FIA caused sterile draining abscesses. The skin testing results suggest that the CMR vaccine is a better alternative than the WC vaccines because of the lack of late granuloma formation by CMR.
KW - abscesses
KW - bacterial diseases
KW - cell mediated immunity
KW - disease control
KW - disease prevention
KW - dog diseases
KW - humoral immunity
KW - immunity
KW - immunization
KW - skin tests
KW - vaccination
KW - vaccines
KW - Coxiella
KW - Coxiella burnetii
KW - dogs
KW - Coxiellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Coxiella
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - abscess
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cellular immunity
KW - immune sensitization
KW - intradermal tests
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological characterization and serological identification of Bacillus cereus diarrhoeal factor.
AU - Bennett, R. W.
AU - Murthy, G.
AU - Kaylor, L.
AU - Cox, S.
AU - Harmon, S. M.
JO - Netherlands Milk and Dairy Journal
JF - Netherlands Milk and Dairy Journal
Y1 - 1993///
VL - 47
IS - 2
SP - 105
EP - 120
SN - 0028-209X
AD - Bennett, R. W.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19940401032. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
KW - antigens
KW - characterization
KW - cows
KW - enterotoxins
KW - Bacillus cereus
KW - cattle
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - Bacillus cereus in milk and milk products
KW - bacterium
KW - immunogens
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DB - lhh
ER -
TY - JOUR
T1 - The food additive petition process: recent data.
AU - Rulis, A. M.
AU - Tarantino, L. M.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 1993///
VL - 48
IS - 1
SP - 137
EP - 151
SN - 0015-6361
AD - Rulis, A. M.: Office of Premarket Approval, Center of Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19941406920. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The safety evaluation procedure for food additive petitions in the USA is described. Highlights of data on the actual performance of the process at the Food and Drug Administration (FDA) are summarized and included in figures contained in an appendix to the paper. The types of data that are required by the FDA to review a petition, the process under which such petitions are reviewed and the ideal time frames associated with petition review are presented. Aspects of the types of petitions often submitted to the FDA by members of the enzyme industry, such as generally recognized as safe (GRAS) affirmation and/or food additive petitions on enzyme preparations, are discussed, with thoughts that may help in designing such petitions to minimize any potential difficulties that may arise during FDA review.
KW - food additives
KW - food legislation
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Additives (QQ130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety limits for nutrient intakes: concepts and data requirements.
AU - Hathcock, J. N.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1993///
VL - 51
IS - 9
SP - 278
EP - 285
SN - 0029-6643
AD - Hathcock, J. N.: Division of Science and Applied Technology, Office of Special Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19941407783. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - The acceptability criteria for toxicity data for use in identifying safety limits are an issue of major importance and must be resolved before calculated limits can be used to support policy or regulatory decisions. An advantage of adopting a standard formula involving systematically varying safety factors to calculate safety limits is that the margin of safety below the expected range of toxicity for each nutrient would be systematic, without having the safety limit for any nutrient regress below its US recommended daily allowance. Once the data acceptability criteria were met, the safety limit could be identified objectively. The confidence in the safety limits will be enhanced if the objectives, data criteria, and the quantitative method have been agreed upon ahead of time by groups responsible for nutrition and health policy. Even with such agreement, the confidence in using such procedures to support policy decisions will be improved by the extent and quality of the data on toxicity and adverse reactions associated with consumption of excessive levels of the nutrients under consideration.
KW - food supplements
KW - nutrient requirements
KW - safety
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dietary standards
KW - food requirements
KW - nutritional requirements
KW - Physiology of Human Nutrition (VV120)
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DB - lhh
ER -
TY - JOUR
T1 - An overview of occupational hazards among veterinarians, with particular reference to pregnant women.
AU - Moore, R. M.
AU - Davis, Y. M.
AU - Kaczmarek, R. G.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1993///
VL - 54
IS - 3
SP - 113
EP - 120
SN - 0002-8894
AD - Moore, R. M.: Center for Devices and Radiological Health, FDA, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19932292960. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Hazards covered in this review are ionizing radiation, physical trauma, zoonotic diseases (the most important being toxoplasmosis and listeriosis), needlestick injury, reactions to latex gloves,and chemicals (including ethylene oxide, antineoplastic drugs, and anaesthetic gases such as halothane and methoxyflurane).
KW - adverse effects
KW - hazards
KW - inhaled anaesthetics
KW - occupational hazards
KW - pregnancy
KW - safety at work
KW - veterinarians
KW - veterinary practice
KW - women
KW - zoonoses
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - gestation
KW - inhaled anesthetics
KW - occupational safety
KW - veterinary surgeons
KW - vets
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Veterinary Profession (CC720) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
KW - Women (UU500)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth of Salmonella spp. in cantaloupe, watermelon, and honeydew melons.
AU - Golden, D. A.
AU - Rhodehamel, E. J.
AU - Kautter, D. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1993///
VL - 56
IS - 3
SP - 194
EP - 196
SN - 0362-028X
AD - Golden, D. A.: Division of HACCP Programs, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19931379429. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition; Horticultural Science; Postharvest Research
N2 - The ability of Salmonella spp. to grow on the interior tissues of cantaloupe, watermelon and honeydew melons was investigated. Pieces of rind-free melons (pH 5.90-6.67) and tryptic soya broth (TSB, pH 5.90) were inoculated with a mixed culture (~ 100 c.f.u./g or ml) containing equal proportions of 5 spp. of Salmonella (S. anatum, S. chester, S. havana, S. poona and S. seftenberg). Inoculated melon pieces and TSB were incubated for 24 h at 5 or 23°C. Viable populations of salmonellae were determined by surface plating test portions on Hektoen enteric agar. Results indicated that Salmonella growth was rapid and prolific on the melons and in TSB at 23°C incubation. Final populations on watermelons were ~ 1.0 log10 greater than populations on cataloupe and honeydew and in TSB. Although viable Salmonella populations on melons and in TSB did not increase during the 24-h incubation at 5°C, little or no decrease in viable populations was observed.
KW - biodeterioration
KW - contamination
KW - melons
KW - pathogens
KW - Bacteria
KW - Cucumis melo
KW - Salmonella
KW - Salmonella anatum
KW - prokaryotes
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - bacterium
KW - Salmonella chester
KW - Salmonella havana
KW - Salmonella poona
KW - Salmonella seftenberg
KW - Biodeterioration (SS300)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931379429&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Abbreviated preenrichment period for recovery of Salmonella spp. from selected low-moisture dairy foods.
AU - Hammack, T. S.
AU - Satchell, F. B.
AU - Andrews, W. H.
AU - Amaguana, R. M.
AU - June, G. A.
AU - Sherrod, P. S.
AU - Koopman, L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1993///
VL - 56
IS - 3
SP - 201
EP - 204
SN - 0362-028X
AD - Hammack, T. S.: Division of Microbiology, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19930458797. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9000-71-9. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - A 6- and a 24-h pre-enrichment procedure were compared for their ability to recover Salmonella spp. from selected low-moisture milk products (instant and non-instant dried skim milk, dried whole milk, lactic casein and rennet casein). The foods were artificially inoculated several days before analysis, and 20 replicate test portions per procedure from each food were examined in each experiment. Samples examined by the 6-h abbreviated procedure were pre-enriched for 6 h at 35°C in an air incubator or water bath and centrifuged at 4100 ×gn for 10 min. Pellets were suspended in tetrathionate broth and incubated for 24 h at 35°C. For the 24-h standard procedure test portions were pre-enriched for 24 h at 35°C in an air incubator, sub-cultured to tetrathionate broth, and incubated for 24 h at 35°C. Selective enrichment broths from both procedures were streaked onto selective agar plates, and presumptive Salmonella isolates were identified by conventional biochemical and serological tests. Recovery of Salmonella spp. from instant dried skim milk and dried whole milk was equivalent for both pre-enrichment procedures. However, the relative effectiveness of the 2 procedures varied in the recovery of Salmonella spp. from non-instant dried skim milk, lactic casein and rennet casein.
KW - biodeterioration
KW - Casein
KW - Cows
KW - detection
KW - Dried milk
KW - Dried skim milk
KW - Milk products
KW - Pathogens
KW - recovery
KW - Skim milk
KW - Techniques
KW - Bacteria
KW - cattle
KW - Salmonella
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - dairy products
KW - milk powder
KW - nonfat dry milk
KW - Milk and Dairy Produce (QQ010)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930458797&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Campylobacter jejuni in a Washington State shellfish growing bed associated with illness.
AU - Abeyta, C., Jr.
AU - Deeter, F. G.
AU - Kaysner, C. A.
AU - Stott, R. F.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1993///
VL - 56
IS - 4
SP - 323
EP - 325
SN - 0362-028X
AD - Abeyta, C., Jr.: Seafood Product Research Center, Food and Drug Administration, Bothell, WA 98041, USA.
N1 - Accession Number: 19941300519. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - Consumption of raw Pacific oysters (Crassostrea gigas) harvested from a Washington State recreational shellfish bed were associated with illness. Illness occurred within 2 d of ingestion of a half-dozen shellstock oysters. Each oyster consist of c. 20 g of meat. The duration of illness lasted 2 d. Routinely, Campylobacter species have been found in several shellfish beds in the Puget Sound Bay. Its presence in the marine environment appears to be incidental and primarily comes from wild birds, farm runoff, and sewage discharges. This paper describes the first reported case of Campylobacter gastroenteritis associated with raw oyster consumption in the State of Washington with strong evidence for C. jejuni as the aetiologic agent.
KW - biodeterioration
KW - food poisoning
KW - oysters
KW - pathogens
KW - shellfish
KW - USA
KW - Washington
KW - bacteria
KW - Campylobacter jejuni
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - prokaryotes
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - bacterium
KW - United States of America
KW - Biodeterioration (SS300)
KW - Aquatic Biology and Ecology (MM300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Aquatic Produce (QQ060)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941300519&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fluorescent antibodies applied to direct epifluorescent filter technique for microscopic enumeration of Escherichia coli 0157:H7 in milk and juice.
AU - Tortorello, M. L.
AU - Gendel, S. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1993///
VL - 56
IS - 8
SP - 672
EP - 677
SN - 0362-028X
AD - Tortorello, M. L.: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 19940400684. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - In a modification of the direct epifluorescent filter technique (DEFT), a direct fluorescent antibody staining was used for the rapid (<1 h), specific enumeration of foodborne Escherichia coli 0157:H7 by epifluorescence microscopy. Cell counts obtained by this method (Ab-DEFT) correlated well with DEFT counts obtained by acridine orange staining and with viable plate counts ranging from 10 to 108 cells/ml for pure cultures in buffer. Ab-DEFT was also effective for enumerating E. coli 0157:H7 cells inoculated into milk and juice; the sensitivity limit was about 10³ for milk. The highly specific nature of the technique was demonstrated by enumeration of E. coli 0157:H7 cells in the presence of large numbers of indigenous spoilage microorganisms in milk. This is the first known demonstration of the combination of DEFT and antibody probe technology for the specific enumeration of a microbe directly in food without a growth or enrichment step.
KW - antibodies
KW - biodeterioration
KW - cows
KW - enumeration
KW - fruit juices
KW - milk
KW - pathogens
KW - probes
KW - techniques
KW - bacteria
KW - cattle
KW - Escherichia coli
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - E. coli
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940400684&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxic mushroom contamination of wild mushrooms in commercial distribution.
AU - Gecan, J. S.
AU - Cichowicz, S. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1993///
VL - 56
IS - 8
SP - 730
EP - 734
SN - 0362-028X
AD - Gecan, J. S.: Division of Microanalytical Evaluations, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941200242. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The problem of poisoning by ingestion of toxic, wild-picked morel mushrooms when collectors inadvertently include toxic look-alike species with the edible wild species offered for sale is discussed. A 2-yr survey conducted by the Food and Drug Administration (FDA) showed 21% of the morel and 15% of the wild mixed mushrooms were contaminated with toxic look-alike species: Verpa bohemica and Gyromitra esculenta. All of the survey samples that were contaminated with toxic species were imported from France or India. Present regulatory controls include FDA Import Alerts for morels contaminated with G. esculenta and V. bohemica and in some US states regulations require the licensing of harvesters of wild mushrooms and the prohibition of the sale of wild-picked mushrooms through retail outlets.
KW - contamination
KW - edible fungi
KW - mushrooms
KW - poisonous fungi
KW - regulations
KW - USA
KW - fungi
KW - Gyromitra esculenta
KW - Morchellaceae
KW - eukaryotes
KW - Gyromitra
KW - Discinaceae
KW - Pezizales
KW - Pezizomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Morchellaceae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungus
KW - poisonous mushrooms
KW - rules
KW - United States of America
KW - Verpa
KW - Verpa bohemica
KW - Laws and Regulations (DD500)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Weeds and Noxious Plants (FF500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200242&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Circumsporozoite protein gene of Plasmodium simium, a Plasmodium vivax-like monkey malaria parasite.
AU - Goldman, I. F.
AU - Qari, S. H.
AU - Millet, P. G.
AU - Collins, W. E.
AU - Lal, A. A.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1993///
VL - 57
IS - 1
SP - 177
EP - 180
SN - 0166-6851
AD - Goldman, I. F.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930802876. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Amplification of the circumsporozoite (CS) protein gene of P. simium using P. vivax CS gene primers yielded a DNA fragment of approximately 1.2 kb. A total of 9 CS clones were sequenced, 7 of these, which were 1161 bp long, had the repeat sequence GDRA (A/D) GQPA, which is similar to the originally reported CS protein repeat sequence from the Belem, Sal 1 and North Korean strains of P. vivax. The 2 other clones had the variant P. vivax CS repeat sequence ANGA (G/D) (N/D/) QPG, recently described in parasites from Thailand, Papua New Guinea and Brazil, and were 1191 bp long. The gene sequence outside the repeat region of all 9 clones was identical to the previously described P. vivax CS protein gene sequence. P. vivax MAbs directed against the sequence GDR (A/D) GQPAG reacted with the sporozoites of P. simium, but MAb directed against the sequence ANGAGNQPG did not.
KW - circumsporozoite protein
KW - Genes
KW - Molecular genetics
KW - Nucleotide sequences
KW - parasites
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium simium
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - biochemical genetics
KW - DNA sequences
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930802876&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cloning and characterization of differentially expressed genes from in vitro-grown 'amastigotes' of Leishmania donovani.
AU - Joshi, M.
AU - Dwyer, D. M.
AU - Nakhasi, H. L.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1993///
VL - 58
IS - 2
SP - 345
EP - 354
SN - 0166-6851
AD - Joshi, M.: Laboratory of Biochemistry, Division of Biochemistry and Biophysics, CBER, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA.
N1 - Accession Number: 19930804493. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - An axenic culture system was used which permits the continuous generation and cycling of L. donovani from promastigotes to 'amastigotes' in vitro. cDNA libraries were constructed from poly(A)+ RNA isolated from both the promastigote and amastigote forms. Using differential cDNA hybridization techniques, 3 unique cDNA clones (P17, A41 and A45) were isolated from the amastigote library. To assess whether these clones were differentially expressed by the promastigotes or amastigotes, they were hybridized to RNA isolated from each of these parasite forms in Northern and slot-blots. Results of these analyses showed that amastigotes had about 2-fold higher levels of the A41 and A45 RNAs compared to the promastigotes. Promastigotes showed about 2-fold higher levels of the P17 RNA than amastigotes. Nucleotide sequence analysis and comparison with those in Gene bank, revealed that the 3 cDNAs represent unique leishmanial genes. Comparison of the deduced amino acid sequences revealed that: P17 open reading frame (ORF) had significant similarity with a soybean ribosomal protein S11; A41 ORF with a Bacillus subtilis spore germination gene (gerC) and A45 ORF with yeast stress-inducible protein (STI1). It is noted that, of the 3 cDNAs identified, the A45-encoded protein was recognized by sera from patients with clinically active visceral leishmaniasis and was encoded by a single copy gene.<new para>ADDITIONAL ABSTRACT:<new para>The authors report the isolation of 3 cDNA clones encoding mRNAs that are differentially expressed by in vitro derived pro- and "amastigotes". One of these mRNA encodes a protein that was recognized by sera from patients with visceral leishmaniasis.Carolyn A. Brown
KW - amastigotes
KW - complementary DNA
KW - Developmental stages
KW - Genes
KW - Human diseases
KW - Molecular genetics
KW - Nucleotide sequences
KW - parasites
KW - promastigotes
KW - Leishmania donovani
KW - protozoa
KW - Sarcomastigophora
KW - Trypanosomatidae
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - cDNA
KW - DNA sequences
KW - gene cloning
KW - growth phase
KW - ribosomal protein
KW - stress-inducible protein
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804493&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intakes and food sources of fructose in the United States.
AU - Park, Y. K.
AU - Yetley, E. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1993///
VL - 58
IS - 5, SUPP
SP - 737S
EP - 747S
SN - 0002-9165
AD - Park, Y. K.: Office of Special Nutritionals, HFS-465, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941405170. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 57-48-7. Subject Subsets: Human Nutrition; Sugar Industry
N2 - Examination of the per capita disappearance data for sweeteners and other sources of fructose showed that during the past 2 decades there was a considerable increase in the availability of free fructose in the US food supply. However, the availability of the total amount of fructose, which includes free and bound fructose, has remained relatively constant. Estimates of the average daily intake of fructose, based on the l977-78 USDA Nationwide Food Consumption Survey, ranged from 15 g for infants to 54 g for males aged 15-18 years of age with a mean of 37 g for the total population. These values represent 7-9% of the energy intake (8% for the total population). For most sex/age groups nonalcoholic beverages (e.g. soft drinks and fruit-flavoured drinks) and grain products (e.g. sweet bakery products) were the major sources of fructose; fruits and fruit products were the major sources of naturally occurring fructose; nonalcoholic beverages were the major source of added fructose.
KW - diet studies
KW - foods
KW - fructose
KW - intake
KW - sources
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fruit sugar
KW - ketohexose
KW - laevulose
KW - levulose
KW - United States of America
KW - Diet Studies (VV110)
KW - Sugar and Sugar Products (QQ020)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405170&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and enumeration of Listeria monocytogenes by nonradioactive DNA probe colony hybridization.
AU - Datta, A. R.
AU - Moore, M. A.
AU - Wentz, B. A.
AU - Lane, J.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1993///
VL - 59
IS - 1
SP - 144
EP - 149
SN - 0099-2240
AD - Datta, A. R.: Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19951303591. Publication Type: Journal Article. Language: English. Number of References: 42 ref.
N2 - A plasmid containing the cloned listeriolysin gene of Listeria monocytogenes was used as a probe to identify Listeria strs by DNA colony hybridization. The probe DNA was labeled with horseradish peroxidase in the presence of glutaraldehyde. After the hybridization and wash procedures, the hybrid molecules were detected by luminescence, which resulted from the oxidation of luminol by a horseradish peroxidase-hydrogen peroxide-coupled reaction. Of the 150 Listeria strs and 16 non-Listeria strs examined, the probe hybridized only with L. monocytogenes. The technique was also used to enumerate L. monocytogenes in artifically contaminated foods.
KW - biodeterioration
KW - DNA probes
KW - genes
KW - identification
KW - pathogens
KW - production
KW - techniques
KW - bacteria
KW - Listeria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Listeria
KW - bacterium
KW - listeriolysin
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951303591&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence of a 27-kilodalton gamete antigen of Plasmodium reichenowi and comparison with Pfg27 of Plasmodium falciparum.
AU - Lal, A. A.
AU - Goldman, I. F.
AU - Collins, W. E.
AU - Kumar, N.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1993///
VL - 59
IS - 1
SP - 175
EP - 176
SN - 0166-6851
AD - Lal, A. A.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930804777. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - The Prg 27 gene was isolated by amplification of Plasmodium reichenowi genomic DNA using oligonucleotide primer sequences based on the sequence of the P. falciparum gene (Pfg 27). A 600-bp fragment was obtained and cloned for sequence analysis. 6 of the 16 nucleotide changes between Prg 27 and Pfg 27 were 3rd base silent changes. 5 of the remaining non-silent changes resulted in a change from valine to iso-leucine or vice versa, and 2 nucleotide substitutions resulted in a change from serine to threonine or vice versa.
KW - antigens
KW - Developmental stages
KW - gametes
KW - Genes
KW - Human diseases
KW - Molecular genetics
KW - Nucleotide sequences
KW - parasites
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium
KW - Plasmodium falciparum
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium
KW - 27-kDa
KW - antigenicity
KW - biochemical genetics
KW - DNA sequences
KW - growth phase
KW - immunogens
KW - Plasmodium reichenowi
KW - sequence
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804777&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of hepatitis A virus in Mercenaria mercenaria by coupled reverse transcription and polymerase chain reaction.
AU - Goswami, B. B.
AU - Koch, W. H.
AU - Cebula, T. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1993///
VL - 59
IS - 9
SP - 2765
EP - 2770
SN - 0099-2240
AD - Goswami, B. B.: Division of Molecular Biological Research and Evaluation, Food and Drug Administration, 200 C Street, SW, Washington, D.C. 20204, USA.
N1 - Accession Number: 19951303619. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - A technique is described for the detection of Hepatitis A virus (HAV) in shellfish based on reverse transcription coupled with the polymerase chain reaction. RNA is isolated from hard-shell clam tissue and reverse transcribed with avian myeloblastosis virus reverse transcriptase. A portion of the cDNA pool is then amplified with primers specific for HAV. In experiments with an in vitro-synthesized HAV transcript, it was possible to detect HAV sequence in the presence of a 200-million-fold excess of shellfish RNA. When intact virus was added to shellfish tissue before the isolation of RNA, the method was capable of detecting 10 viral RNA molecules in a reaction mixture.
KW - biodeterioration
KW - detection
KW - pathogens
KW - polymerase chain reaction
KW - shellfish
KW - techniques
KW - hepatitis A virus
KW - Mercenaria mercenaria
KW - viruses
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Mercenaria
KW - Veneridae
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - PCR
KW - reversed transcription
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Aquatic Produce (QQ060)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951303619&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Research program for neurotoxic disorders and other adverse health outcomes at hazardous chemical sites in the United States of America.
AU - Amler, R. W.
AU - Lybarger, J. A.
JO - Environmental Research (New York)
JF - Environmental Research (New York)
Y1 - 1993///
VL - 61
IS - 2
SP - 279
EP - 284
SN - 0013-9351
AD - Amler, R. W.: US Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Division of Health Studies, Atlanta, GA 30333, USA.
N1 - Accession Number: 19932024091. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - chemical industry
KW - health
KW - Pollution
KW - toxic substances
KW - waste disposal
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - environmental pollution
KW - poisons
KW - United States of America
KW - Pollution and Degradation (PP600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932024091&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pertussis toxin-induced alterations of murine hepatic drug metabolism following adminstration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed.
AU - Ansher, S.
AU - Thompson, W.
AU - Bridgewater, J.
AU - Snoy, P.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1993///
VL - 61
IS - 10
SP - 4240
EP - 4247
SN - 0019-9567
AD - Ansher, S.: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952006366. Publication Type: Journal Article. Language: English. Number of References: 32 ref.
N2 - Administration of pertussis toxin (PT) in combination with diphtheria and tetanus toxoids adsorbed (DT vaccine) or with acellular pertussis vaccine adsorbed and diphtheria and tetanus toxoids (APDT) elicits dose- and time-dependent alterations in hepatic drug metabolism in mice. Cytochrome P-450 (P-450) levels were inhibited more than 50% at 7 days following a single injection of PT mixed with either vaccine. When combined with DT vaccine, 125 ng of PT was required to produce this effect, while as little as 16 ng of PT combined with APDT vaccine inhibited P-450 levels. The inhibition of P-450 levels is similar to that observed after a single injection of diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP). Alterations of P-450 levels were accompanied by increased activities of quinone reductase but not with changes in plasma interleukin-6 or tumour necrosis factor levels. Other Bordetella pertussis virulence factors, such as filamentous haemagglutinin, fimbriae and pertactin, were also tested but had no significant effect on hepatic drug metabolism. Endotoxin or preparations containing endotoxin caused alterations in hepatic drug metabolism within 24 h, concomitant with increased interleukin-6 tumour necrosis factor levels, but these effects had resolved by 1 week. DTP vaccine and preparations containing PT caused a marked induction of gamma interferon coincident with the maximal inhibition of P-450 levels. This effect was not present with DP or APDT vaccine alone, nor with endotoxin or any combination of factors that did not contain PT. These results demonstrate that PT is a necessary component for the sustained effects of DTP vaccine on hepatic drug metabolism and suggests a role for gamma interferon in this process.
KW - diphtheria
KW - disease models
KW - experimental infections
KW - laboratory animals
KW - pertussis
KW - toxins
KW - vaccines
KW - Bordetella pertussis
KW - Corynebacterium diphtheriae
KW - mice
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Corynebacterium
KW - Corynebacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - whooping cough
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time.
AU - Golding, H.
AU - Blumenthal, R.
AU - Manischewitz, J.
AU - Littman, D. R.
AU - Dimitrov, D. S.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1993///
VL - 67
IS - 11
SP - 6469
EP - 6475
SN - 0022-538X
AD - Golding, H.: Division of Virology, Food and Drug Administration, Bethesda, Maryland 20892, USA.
N1 - Accession Number: 19952009978. Publication Type: Journal Article. Language: English. Number of References: 38 ref.
KW - cd4 antigens
KW - cd8 antigens
KW - cell fusion
KW - glycoproteins
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - infections
KW - pathology
KW - viral diseases
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CD4
KW - CD8
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009978&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cell proliferation by cell cycle analysis in young and old dietary restricted mice.
AU - Lu, M. H.
AU - Hinson, W. G.
AU - Turturro, A.
AU - Sheldon, W. G.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1993///
VL - 68
IS - 1/3
SP - 151
EP - 162
SN - 0047-6374
AD - Lu, M. H.: Food and Drug Administration, National Center for Toxicological Research (NCTR), Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19931463679. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Human Nutrition
N2 - The effect of dietary restriction (DR) on cell proliferation (determined by tissue cell cycle analysis) was investigated in young and old male B6C3F1 mice. Using the percentage of S-phase cells as an index of cell proliferation, it was found that DR inhibited cell proliferation in spleen and thymus in young mice. No significant changes were found in bone marrow and kidney in the free fed or DR mice regardless of age. In old mice, the DR effect was observed in spleen only. When age increased, a parallel decline in cell proliferation was evidenced by a reduced percentage of S-phase cells. DR produced a greater cell cycle effect in the young than in the old mice. It is suggested that inhibition by DR may be affected by type of tissue, age, length of DR and capacity or rate of cell proliferation.
KW - age
KW - Cell growth
KW - Diet treatment
KW - restricted feeding
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cell elongation
KW - diet prescription
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931463679&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of caloric restriction on aflatoxin B1-induced DNA synthesis, AFB1-DNA binding and cell proliferation in Fischer 344 rats.
AU - Chou, M. W.
AU - Lu, M. H.
AU - Pegram, R. A.
AU - Gao, P.
AU - Cao, S.
AU - Kong, J.
AU - Hart, R. W.
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
Y1 - 1993///
VL - 70
IS - 1/2
SP - 23
EP - 33
SN - 0047-6374
AD - Chou, M. W.: National Center for Toxicological Research (NCTR), Jefferson, AR 72079, USA.
N1 - Accession Number: 19931467823. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Adult male Fischer rats maintained on a reduced energy diet (60% of ad libitum food intake) for 6 weeks, showed a decrease in the binding of aflatoxin B1 (AFB1) to hepatic or renal nuclear DNA and a reduction of AFB1-induced hepatocellular damage. Repeated dosing of rats with AFB1 resulted in the inhibition of hepatic and renal DNA synthesis, estimated by [³H]thymidine incorporation. The rate of DNA synthesis was greater in ad libitum-fed (AL) than in energy-restricted (ER) rats. 3 days after AFB1 dosing, the rate of DNA synthesis had recovered to control level. Cell cycle analyses measured by a flow cytometric method on kidney cells of both AL and ER rats showed that there were no significant changes in cell populations in the S phase between these 2 groups. AFB1 inhibited cell proliferation by about 33%. The restoration of cell proliferation in kidney cells was found on the 3rd day after AFB1 dosing . The rate of the regenerative cell proliferation was found to be slightly greater in AL than in ER rats. The AFB1-induced regenerative DNA synthesis in liver and kidney was decreased by ER.
KW - aflatoxins
KW - binding
KW - carcinogenesis
KW - cell growth
KW - cytotoxicity
KW - diet
KW - DNA
KW - food restriction
KW - mycotoxins
KW - poisoning
KW - restricted feeding
KW - susceptibility
KW - synthesis
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cell elongation
KW - deoxyribonucleic acid
KW - fungal toxins
KW - toxicosis
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Urban epizootic of rabies in Mexico: epidemiology and impact of animal bite injuries.
AU - Eng, T. R.
AU - Fishbein, D. B.
AU - Talamante, H. E.
AU - Hall, D. B.
AU - Chavez, G. F.
AU - Dobbins, J. G.
AU - Muro, F. J.
AU - Bustos, J. L.
AU - Angeles Ricardy, M. de los
AU - Munguia, A.
AU - Carrasco, J.
AU - Robles, A. R.
AU - Baer, G. M.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1993///
VL - 71
IS - 5
SP - 615
EP - 624
SN - 0042-9686
AD - Eng, T. R.: Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19952006012. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 37 ref.
N2 - From 1 July 1987 to 31 December 1988, a total of 317 animals (91% of which were dogs) were confirmed to have rabies in Hermosillo, Mexico. The median age of rabid dogs was 1 year, 69% were male, and 98% were owned. The epizootic started in the southern areas of the city, rapidly involved the entire city, and persisted mainly in lower socioeconomic status areas. The area of the city and mean household size were significant predictor variables for the population density of rabid dogs around household clusters (Poisson linear regression, P <0.001 and P = 0.03, resp.). Approximately 2.5% of city residents were bitten by dogs in 1987, with the rate of reported dog bite injuries being positively correlated with mean household size and the proportion of households that owned dogs. Visits to the city health centre for evaluation of possible exposures to rabies increased by 135% after the start of the epizootic; approximately 273 per 100 000 city residents were administered a full or partial course of rabies post-exposure prophylaxis in 1987. Children were at greatest risk for exposures to rabies, accounting for 60% of all reported animal bite injuries evaluated at the health centre. Also they were more likely than older persons to have received bite injuries to the head, face, and neck (odds ratio = 21.6, 95% confidence interval = 5.4, 186.5).
KW - bites
KW - epidemiology
KW - rabies
KW - zoonoses
KW - Mexico
KW - North America
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006012&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine perspective.
AU - Price, W. D.
AU - Lovell, R. A.
AU - McChesney, D. G.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1993///
VL - 71
IS - 9
SP - 2556
EP - 2562
SN - 0021-8812
AD - Price, W. D.: Division of Animal Feeds, Center for Veterinary Medicine, FDA, Rockville, MD 20855, USA.
N1 - Accession Number: 19930110333. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 51481-10-8, 17924-92-4. Subject Subsets: Veterinary Science; Animal Nutrition; Medical & Veterinary Mycology; Wheat, Barley & Triticale Abstracts; Maize
N2 - The objectives of this review are to provide information on the FDA (US Food and Drug Administration) Feed Contaminants Program, outline the legal history of aflatoxins and their current action levels, and report on the levels of aflatoxins, fumonisins, vomitoxin, ochratoxin A and zearalenone in domestic and imported surveillance feed samples during fiscal years 1989 to 1992, and, lastly disseminate information on naturally occurring toxins encountered recently by the Center for Veterinary Medicine. 10 of 644 (1.6%) domestic maize samples and 7 of 106 (6.6%) domestic cottonseed samples contained aflatoxins >300 ppb. The mean fumonisin level in the 1990 survey of 85 maize screening samples was 12.1, values ranging from 2.6 to 32 mg/kg. Mean vomitoxin levels in the 1991 survey of 207 winter wheat samples and 206 spring wheat samples were 2.4 and 0.9 mg/kg, respectively. Ochratoxin A was not detected in 168 samples. Zearalenone was detected at >0.15 mg/kg in only 1 of 161 samples. Cottonseed containing 13 000 mg gossypol was recently implicated in the deaths of dairy cows. Crambe meal and canola rapeseed meal are sanctioned for use in feed with certain restrictions, including the levels of glucosinolates.
KW - aflatoxins
KW - biodeterioration
KW - contamination
KW - cottonseed
KW - crambe meal
KW - feeds
KW - fumonisins
KW - glucosinolates
KW - maize
KW - mycotoxins
KW - ochratoxins
KW - rapeseed
KW - reviews
KW - vomitoxin
KW - wheat
KW - zearalenone
KW - USA
KW - fungi
KW - Fusarium proliferatum
KW - Gibberella fujikuroi
KW - Hypocreaceae
KW - Triticum
KW - Zea mays
KW - eukaryotes
KW - Fusarium
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Gibberella
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Zea
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - corn
KW - deoxynivalenol
KW - f-2 toxin
KW - feeding stuffs
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Plant Composition (FF040)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930110333&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The food safety of transgenic animals: implications from traditional breeding.
AU - Berkowitz, D. B.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1993///
VL - 71
IS - SUP 3
SP - 43
EP - 46
SN - 0021-8812
AD - Berkowitz, D. B.: Office of Biotechnology HF-6, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19940102042. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Agricultural Biotechnology; Animal Breeding; Human Nutrition
N2 - This review concludes that foods produced from healthy transgenic livestock developed for genetic improvement purposes are likely to be as safe as the foods from the non-transgenic stock from which the transgenics were developed.
KW - biotechnology
KW - food safety
KW - foods
KW - genetic engineering
KW - livestock
KW - meat
KW - reviews
KW - safety
KW - transgenics
KW - genetic manipulation
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Food Science and Food Products (Human) (QQ000)
KW - Occupational Health and Safety (VV900)
KW - Meat Produce (QQ030)
KW - Social Sciences (General) (UU000)
KW - Laws and Regulations (DD500)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth of Salmonella enteritidis in grade A eggs during prolonged storage.
AU - Hammack, T. S.
AU - Sherrod, P. S.
AU - Bruce, V. R.
AU - June, G. A.
AU - Satchell, F. B.
AU - Andrews, W. H.
JO - Poultry Science
JF - Poultry Science
Y1 - 1993///
VL - 72
IS - 2
SP - 373
EP - 377
SN - 0032-5791
AD - Hammack, T. S.: Division of Microbiology, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19942205435. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Poultry; Veterinary Science
N2 - Migration of S. enteritidis through egg albumen to the yolk and its subsequent growth in the yolk were examined. Submersion of eggs in 0.1% mercuric chloride solution for 1 h followed by submersion in 70% ethanol for 30 min resulted in an eggshell surface from which no Salmonella organisms were recovered. The eggs were then inoculated with S. enteritidis under the shell membrane. Although growth of S. enteritidis was negligible in eggs refrigerated for up to 16 days, the population level of the organism increased by more than 8 log10 units in unrefrigerated eggs stored for the same amount of time.
KW - bacterial diseases
KW - biodeterioration
KW - disinfection
KW - eggs
KW - growth
KW - pathogens
KW - storage
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - eggshell
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biodeterioration (SS300)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Storage and Preservation (QQ110)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942205435&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The colonization of solid PVC surfaces and the acquisition of resistance to germicides by water micro-organisms.
AU - Vess, R. W.
AU - Anderson, R. L.
AU - Carr, J. H.
AU - Bond, W. W.
AU - Favero, M. S.
JO - Journal of Applied Bacteriology
JF - Journal of Applied Bacteriology
Y1 - 1993///
VL - 74
IS - 2
SP - 215
EP - 221
SN - 0021-8847
AD - Vess, R. W.: Nosocomial Infections Laboratory Branch, Hospital Infections Program, National Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19931379388. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9002-86-2.
N2 - Six common water bacteria were examined for their ability to colonize polyvinyl chloride (PVC) surfaces, survive various germicidal treatment, and re-establish themselves in sterile distilled water (SDW). For each test, two 30.4 cm PVC pipes attached to a 90° PVC elbow were filled with 600 ml of distilled water inoculated with either Pseudomonas aeruginosa, P. cepacia, P. mesophilica, Acinetobacter anitratus, Mycobacterium chelonae or M. chelonae var. abscessus. After 8 weeks contaminated water was removed and the pipes were exposed to 600 ml of 1:213 iodophor disinfectant (ID), 1:128 phenolic detergent (P), 1:256 quaternary ammonium compound (QA), stock iodophor antiseptic (IA), 2% formaldehyde (F), 10-15 p.p.m. free chlorine (C), 2% glutaraldehyde (G) and 70% ethanol (E). These germicides were periodically sampled, neutralized and examined for surviving organisms. After exposure for 7 d the germicides were removed and each pipe was refilled with SDW. This was assayed at 7 d intervals to determine microbial re-establishment. Pseudomonads were isolated directly from ID, QA, C, P and F, and mycobacteria from QA, IA, ID, P, G, C and F. P. aeruginosa and P. cepacia survived in PVC pipes after 7 d of exposure to P, ID and C; P. mesophilica, after C and ID; and both mycobacteria, after C. Scanning electron microscopy examination of PVC remnants revealed bacterial attachment and formation of extracellular material with embedded cells. The studies showed that common water bacteria can attach and colonize the interior surface of PVC pipes and develop significant resistance to the action of certain germicides. It was concluded that specific disinfection strategies are needed to control microbial populations that form in water distribution systems.
KW - biodeterioration
KW - disinfection
KW - microbial contamination
KW - pathogens
KW - Poly(vinyl chloride)
KW - survival
KW - bacteria
KW - Burkholderia cepacia
KW - Methylobacterium mesophilicum
KW - Mycobacterium chelonae
KW - Pseudomonas aeruginosa
KW - prokaryotes
KW - Burkholderia
KW - Burkholderiaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Acinetobacter
KW - Moraxellaceae
KW - Methylobacterium
KW - Methylobacteriaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Acinetobacter anitratus
KW - bacterium
KW - Berkholderia
KW - Pseudomonas cepacia
KW - Pseudomonas mesophilica
KW - PVC
KW - Pesticides and Drugs (General) (HH400)
KW - Biodeterioration (SS300)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Biodeterioration (Non-biological Products) (SS310) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
KW - Public Services and Infrastructure (UU300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - St Louis encephalitis virus establishes a productive, cytopathic and persistent infection of Sf9 cells.
AU - Zhang PengFei
AU - Klutch, M.
AU - Muller, J.
AU - Marcus-Sekura, C. J.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1993///
VL - 74
IS - 8
SP - 1703
EP - 1708
SN - 0022-1317
AD - Zhang PengFei: Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19950503715. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The Spodoptera frugiperda Sf9 cell line, commonly used for gene expression by recombinant baculovirus, was productively infected by St Louis encephalitis (SLE) virus, a flavivirus. SLE viral infection produced a c.p.e. in the Sf9 cells characterized by giant cells and the presence of 10-fold fewer cells in the infected cultures after the first week of infection compared with uninoculated control cultures. Infected Sf9 cells expressed SLE viral antigens, and intracellular virus particles were observed by electron microscopy. Titres of cell-associated SLE virus rose slightly over an 8-week period, whereas titres of cell-free virus remained stable, suggesting that SLE virus establishes a productive and persistent infection of Sf9 cells. The SLE virus produced by the Sf9 cells could be neutralized by SLE virus-immune mouse ascitic fluid, and no evidence of escape mutants was detected. Sf9 cells persistently infected with SLE virus could be superinfected with a recombinant baculovirus and expressed recombinant antigen. The successful infection of Sf9 cells by SLE virus represents the first report of production of c.p.e. by SLE virus in insect cells under routine cell culture conditions and of the infection of Sf9 cells by a human pathogen.
KW - arboviruses
KW - cell lines
KW - CYTOPATHOGENICITY
KW - infection
KW - Baculovirus
KW - Flavivirus
KW - Spodoptera frugiperda
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Baculoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Spodoptera
KW - Noctuidae
KW - Lepidoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - arthropod-borne viruses
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - U.S. Food and Drug Administration survey of methyl mercury in canned tuna.
AU - Yess, N. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 1
SP - 36
EP - 38
SN - 1060-3271
AD - Yess, N. J.: U.S. Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19951407120. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 593-74-8. Subject Subsets: Human Nutrition
N2 - Methyl mercury was determined by the US Food and Drug Administration (FDA) in 220 samples of canned tuna collected in 1991. Samples were chosen to represent different styles, colours, and packs as available. Emphasis was placed on water-packed tuna, small can size, and the highest-volume brand names. The average methyl mercury (expressed as Hg) found for the 220 samples was 0.17 ppm; the range was <0.10-0.75 ppm. Statistically, a significantly higher level of methyl mercury was found in solid white and chunk white tuna than was found in chunk light and chunk tuna. Methyl mercury level was not related to can size. None of the 220 samples had methyl mercury levels that exceeded the 1 ppm FDA action level.
KW - canned fish
KW - methylmercury
KW - USA
KW - tuna
KW - Scombridae
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of multiple tetracycline residues in milk using metal chelate affinity chromatography.
AU - Carson, M. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 2
SP - 329
EP - 334
SN - 1060-3271
AD - Carson, M. C.: Center for Veterinary Medicine, Division of Veterinary Medical Research, U.S. Food and Drug Administration, Beltsville, MD 20705, USA.
N1 - Accession Number: 19940403024. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A method was developed for the determination of 7 tetracyclines in milk. Raw milk samples were defatted, acidified and centrifuged to remove proteins, and the tetracyclines were specifically absorbed from the milk by chelation with metal ions bound to small Chelating Sepharose Fast Flow columns. The tetracyclines were removed from these columns with EDTA-containing buffer and the extracts were further cleaned up by centrifugal ultrafiltration. Finally, the extracts were concentrated and analysed simultaneously by on-line concentration. This method had limits of detection for individual tetracyclines of <5 ng/ml, and was validated with fortified milk samples containing tetracyclines at concentrations of 15, 30 and 60 ng/ml. Recoveries were >60% for all tetracyclines at all levels, with good precision. The method was also tested on milk from cows dosed with each of the tetracyclines. Advantages of this method compared with existing methods include its sensitivity, minimal use of organic solvents and speed; with an autosampler, ≥14 samples can be processed and analysed per day.
KW - antibiotic residues
KW - antibiotics
KW - chromatography
KW - cows
KW - determination
KW - drug residues
KW - milk
KW - milk hygiene
KW - residues
KW - tetracyclines
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Residues and Contamination of Animal Products (SS120) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of niacin in fortified food products.
AU - Chase, G. W., Jr.
AU - Landen, W. O., Jr.
AU - Soliman, A. G. M.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 2
SP - 390
EP - 393
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, 60 8th St., N.E., Atlanta, GA 30309, USA.
N1 - Accession Number: 19940403025. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 59-67-6. Subject Subsets: Dairy Science; Human Nutrition; Wheat, Barley & Triticale Abstracts
N2 - An ion-exchange liquid chromatographic (LC) method using an anion-exchange resin column was developed for the determination of niacin in fortified foods (5 types of infant formulae, bread, soup, tuna, egg noodles, pasta products and fortified cereals). Samples were extracted by autoclaving with H2SO4 (1 + 1). Florisil open-column chromatography was used to remove interferences from the sample extracts. Niacin levels were quantified using an LC system with a 250 × 4.1 mm Hamilton PRP-X100 column, a mobile phase of 2% glacial acetic acid in water and UV detection at 254 nm. The limit of detection was 0.11 µg niacin/ml and the standard curve was linear from 0.24 to 0.80 µg niacin/ml. Reproducibility was evaluated by completing 10 repetitive analyses on an infant formula and a macaroni product, which gave an average CV of 2.7%. Mean recovery ±s.d. was 99.8±7.7 (n = 15). The results compared favourably with those of the AOAC microbiological method.
KW - analytical methods
KW - bread
KW - cereal products
KW - cereals
KW - chromatography
KW - cows
KW - determination
KW - estimation
KW - fish
KW - foods
KW - infant formulae
KW - liquid chromatography
KW - nicotinic acid
KW - pasta
KW - vitamins
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alimentary pastes
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - niacin
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of milk-based infant formula. Phase V. Vitamins A and E, folic acid, and pantothenic acid: Food and Drug Administration - Infant Formula Council: collaborative study.
AU - Tanner, J. T.
AU - Barnett, S. A.
AU - Mountford, M. K.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 2
SP - 399
EP - 413
SN - 1060-3271
AD - Tanner, J. T.: Division of Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19940403026. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 59-30-3, 79-83-4, 68-26-8, 1406-18-4. Subject Subsets: Dairy Science; Human Nutrition
N2 - In 1982, the FDA, the Infant Formula Council and its member companies, contract laboratories, and other US government laboratories began a study of analytical methods for the nutrients listed in the Infant Formula Act of 1980 (P.L. 96-359). Four phases of the study have been completed and are discussed in earlier reports. This report provides data on phase V, in which 13 laboratories collaboratively studied individual methods for folic acid, pantothenic acid and vitamin E, in addition to 2 methods for vitamin A. Vitamins A and E were determined by liquid chromatography. Folic acid and pantothenic acid were determined by microbiological methods using acidimetric and/or turbidimetric assays as the determinative step. In most cases, relative s.d. for repeatability (RSDr) and reproducibility, (RSDR) were similar to those predicted using other collaborative studies. RSDr and RSDR values respectively for the 5 methods were 9.35 and 25.44% for folic acid, 4.59 and 10.23% for pantothenic acid, 8.46 and 11.69% for vitamin E, 3.62 and 9.72% for vitamin A (retinol isomers), and 4.9 and 10.5% for vitamin A (retinol). The 5 methods have been adopted first action by AOAC International.
KW - analytical methods
KW - cows
KW - determination
KW - estimation
KW - folic acid
KW - infant formulae
KW - pantothenic acid
KW - retinol
KW - vitamin E
KW - vitamins
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - axerophthol
KW - folacin
KW - folate
KW - infant formula
KW - infant formulas
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence of fungi in shared-use cosmetics available to the public.
AU - Mislivec, P. B.
AU - Bandler, R.
AU - Allen, G.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 2
SP - 430
EP - 436
SN - 1060-3271
AD - Mislivec, P. B.: Division of Microbiology, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19931214573. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Samples of 3027 shared-use cosmetic products, collected from 171 retail establishments worldwide, were tested for fungal contamination. Fungi were present in 10.4% of the products and 3.9% contained fungal pathogens or opportunistic pathogens. Of 423 isolates, Penicillium spp. (91 isolates), followed by Pullularia [Aureobasidium] pullulans (44), Aspergillus spp. (43), Saccharomyces-like yeasts (40), Rhodotorula rubra (31), Alternaria spp. (28), Rhizopus nigricans [R. stolonifer] (22), Cladosporium herbarum (14) and Trichosporon pullulans (14) were the most frequent of 33 genera and 69 spp. isolated. Fungi were isolated from eye products (60.8% of isolates), face products (22.9%) and lip products (14.9%). Pathogenic or opportunistic pathogens accounted for 32.2% of isolates. Fewer fungi were isolated from samples that contained preservatives than without preservatives. It is concluded that there are potential microbiological problems associated with shared-use cosmetics.
KW - biodeterioration
KW - contamination
KW - cosmetics
KW - pathogens
KW - Alternaria
KW - Aspergillus
KW - Aureobasidium pullulans
KW - Cladosporium herbarum
KW - Fungi
KW - Mucoraceae
KW - Penicillium
KW - Rhizopus stolonifer
KW - Rhodotorula mucilaginosa
KW - Saccharomyces
KW - Saccharomycetaceae
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Aureobasidium
KW - Dothioraceae
KW - Dothideales
KW - Cladosporium
KW - Davidiellaceae
KW - Capnodiales
KW - Rhizopus
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Rhodotorula
KW - Sporidiobolales
KW - Microbotryomycetes
KW - Pucciniomycotina
KW - Basidiomycota
KW - Saccharomycetaceae
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Trichosporon
KW - Trichosporonaceae
KW - Tremellales
KW - Tremellomycetes
KW - Agaricomycotina
KW - fungus
KW - Hyphomycetes
KW - Rhodotorula rubra
KW - Trichosporon pullulans
KW - Biodeterioration (SS300)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reliability of mycotoxin assays - an update.
AU - Horwitz, W.
AU - Albert, R.
AU - Nesheim, S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 3
SP - 461
EP - 491
SN - 1060-3271
AD - Horwitz, W.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19931251124. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Medical & Veterinary Mycology
N2 - The precision parameters of method-performance (collaborative) studies for mycotoxins, mainly aflatoxins, in foods and feeds, published during 1991 were recalculated on a uniform basis following the International Union of Pure and Applied Chemistry protocol and the results are reviewed. The primary factor affecting relative standard deviations among laboratories was concentration, more or less independent of analyte, method, matrix and age of study. The overall precision pattern from approx. 1000 data sets showed no improvement in the among-laboratory precision of aflatoxin assays during the past 20 yr. All improvements occurred in within-laboratory precision, indicating a need for laboratories to refer their measurements to common standards and to operate under an external quality assurance programme.
KW - Aflatoxins
KW - assays
KW - biodeterioration
KW - contamination
KW - estimation
KW - feeds
KW - foods
KW - Mycotoxins
KW - standardization
KW - techniques
KW - feeding stuffs
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration (SS300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US Food and Drug Administration monitoring of pesticide residues in infant foods and adult foods eaten by infants/children.
AU - Yess, N. J.
AU - Gunderson, E. L.
AU - Roy, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 3
SP - 492
EP - 507
SN - 1060-3271
AD - Yess, N. J.: US Food and Drug Administration, Office of Plant and Dairy Foods and Beverages, Division of Programs and Enforcement Policy, Washington, DC 20204, USA.
N1 - Accession Number: 19951407150. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration uses 3 approaches to monitor pesticide residues in foods: regulatory monitoring, incidence/level monitoring, and the Total Diet Study. The results of monitoring infant foods and adult foods that may be eaten by infants/children under these 3 approaches are presented. Under regulatory monitoring, which is performed to enforce tolerances set by the U.S. Environmental Protection Agency (EPA), during fiscal years 1985-1991, over 10 000 such domestic and imported food samples were collected and analyzed, and under the Total Diet Study, in which pesticide residue intakes are estimated in foods prepared for consumption, the food items in 27 market baskets were analysed. Under incidence/level monitoring, which is complementary to regulatory monitoring, over 4000 analyses were performed on infant foods and adult foods eaten by children. Fewer than 50 of the 10 000 regulatory samples had violative residues; nearly all of those were residues for which there was no tolerance for the particular commodity/pesticide combination. Under incidence/level monitoring and the Total Diet Study, the levels of pesticide residues found in infant foods and adult foods eaten by children were well below tolerances set by EPA.
KW - children
KW - foods
KW - infant foods
KW - infants
KW - pesticide residues
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of milk-based infant formula. Phase IV. Iodide, linoleic acid, and vitamins D and K: U.S. Food and Drug Administration-Infant Formula Council: collaborative study.
AU - Tanner, J. T.
AU - Barnett, S. A.
AU - Mountford, M. K.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 5
SP - 1042
EP - 1056
SN - 1060-3271
AD - Tanner, J. T.: U.S. Food and Drug Administration, Division of Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19950401676. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 60-33-3, 1406-16-2, 12001-79-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - In 1982, the US FDA, the Infant Formula Council and its member companies, contract laboratories, and other government laboratories began a study of analytical methods for the nutrients listed in the Infant Formula Act of 1980. Phases I, II, III and V have been completed. The present report provides data on Phase IV, in which 13 laboratories collaboratively studied an ion-selective electrode method for analysing iodide, a GC method for linoleic acid, and 2 liquid chromatographic (LC) methods each for vitamins D and K. Data were insufficient to evaluate one each of the LC methods studied for vitamins K and D. The relative s.d. (RSD) are sufficient for the nutrient levels found in infant formula. RSD (%) for repeatability (RSDr) and reproducibility (RSDR), respectively, were as follows: iodide, 4.0-11.4 and 13.5-18.2; linoleic acid, 1.0-1.6 and 3.5-5.1; vitamin K1, 3.2-16.0 and 6.2-19.4; and vitamin D3, 4.2 and 35.0. The recommendation to adopt the method for vitamin D was supported by the results of a mini-study. All laboratories were capable of using these methods with little training. The methods for determination of iodide, linoleic acid, and vitamins D and K in ready-to-feed milk-based infant formulae have been adopted first action by AOAC International.
KW - analytical methods
KW - cows
KW - determination
KW - infant formulae
KW - iodides
KW - linoleic acid
KW - vitamin D
KW - vitamin K
KW - vitamins
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950401676&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide residues in composited milk collected through the U.S. Pasteurized Milk Network.
AU - Trotter, W. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 6
SP - 1220
EP - 1225
SN - 1060-3271
AD - Trotter, W. J.: US Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19960501618. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 72-55-9, 60-57-1. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration (FDA) has implemented a comprehensive monitoring programme to determine the incidence and levels of organohalogen pesticide residues in milk representing most of the USA supply consumed in metropolitan areas. Residue findings for 806 composite milks collected through the Pasteurized Milk Program by the USA Environmental Protection Agency (EPA) in 1990-91 are reported. Milk was collected on a monthly basis from 63 stations selected by EPA for radionuclide monitoring. These stations provide an estimated 80% of the milk delivered to USA population centres. At each station, milk from selected sources had been composited to represent the milk routinely consumed in its metropolitan area. Portions of these composites were forwarded to an FDA contract laboratory for pesticide residue analysis. Pesticide residues were found in 398 (49.4%) of 806 test samples, on the basis of a 0.0005 ppm limit of detection for each residue on a whole-product basis. A total of 455 occurrences of pesticide residues was found; p,p′-DDE and dieldrin accounted for 384 (84.4%) of these occurrences. The highest level was 0.019 ppm p,p′-DDE.
KW - DDE
KW - dieldrin
KW - insecticide residues
KW - organochlorine insecticides
KW - pasteurized milk
KW - pesticide residues
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - p,p'-dichlorodiphenyldichloroethylene
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Chemistry (ZZ600) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Method modification for liquid chromatographic determination of thiamine, riboflavin, and pyridoxine in medical foods.
AU - Chase, G. W.
AU - Landen, W. O., Jr.
AU - Soliman, A. G. M.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 6
SP - 1276
EP - 1280
SN - 1060-3271
AD - Chase, G. W.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 8th St. NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 19950401727. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 65-23-6, 83-88-5, 59-43-8. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - A reversed-phase ion pair liquid chromatographic method developed for the simultaneous determination of thiamin, riboflavin and pyridoxine in perchloric acid extracts of infant formulae was modified to include medical foods (3 dried products and 4 ready-to-feed formulations comprising egg proteins, concentrated skim milk, caseinates, soya protein concentrates, whey proteins and meat proteins). UV detection of thiamin and riboflavin was replaced by fluorescence detection, which resulted in improved sensitivity and specificity. Thiamin was detected by fluorescence after conversion to thiochrome by a post-column reaction with sodium hydroxide and potassium ferricyanide. The method uses a mobile phase of water, acetonitrile, hexanesulphonic acid sodium salt, ammonium hydroxide, and phosphoric acid adjusted to pH 3.6. The column is a 300 × 3.9 mm Nova Pak C18. Limits of detection were 0.05 µg/ml for thiamin and riboflavin and 0.01 µg/ml for pyridoxine by fluorescence detection. The system reproducibility was evaluated by completing 10 repetitive determinations on a medical food that gave CV of 5.9, 6.0 and 10.7% for thiamin, riboflavin and pyridoxine respectively. Mean recoveries (n = 10) were 111, 96.3 and 113% for thiamin, riboflavin and pyridoxine respectively. The results compared favourably with those obtained using AOAC Official Methods 942.23, 940.33 and 961.15 for thiamin, riboflavin and pyridoxine respectively.
KW - analytical methods
KW - caseinates
KW - chromatography
KW - cows
KW - determination
KW - dietetic foods
KW - egg protein
KW - liquid chromatography
KW - meat products
KW - pyridoxine
KW - riboflavin
KW - skim milk
KW - soya protein
KW - techniques
KW - thiamin
KW - vitamins
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - aneurin
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - thiamine
KW - vitamin B1
KW - vitamin B2
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
KW - Other Produce (QQ070)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950401727&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of paraquat and diquat in low-moisture food crops using silica column cleanup and liquid chromatography with UV detection.
AU - Chichila, T. M. P.
AU - Gilvydis, D. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1993///
VL - 76
IS - 6
SP - 1323
EP - 1328
SN - 1060-3271
AD - Chichila, T. M. P.: U.S. Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, Detroit, MI 48207, USA.
N1 - Accession Number: 19952309649. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 2764-72-9, 2074-50-2, 4685-14-7, 1910-42-5. Subject Subsets: Human Nutrition; Weeds; Postharvest Research
N2 - A sample cleanup method was developed for the determination of paraquat (PQ) and diquat (DQ) in low-moisture food crops. Low-moisture commodities, such as milled dry navy beans, are digested in acid. PQ and DQ are isolated from the digestates using a 4 g column of preconditioned silica gel. The analytes are concentrated and then determined by liquid chromatography with a silica analytical column, sodium chloride as an ion-pairing reagent, and acetonitrile as an organic modifier. PD and DQ are determined simultaneously with a diode array UV absorbance detector. Recoveries for PQ and DQ were determined on 3 different fortified low-moisture crops. Fortification levels ranged from 0.01 to 0.30 ppm; average recoveries ranged from 47.5% (DQ) to 95.3% (PQ).
KW - analytical methods
KW - diquat
KW - dried foods
KW - foods
KW - herbicide residues
KW - herbicides
KW - liquid chromatography
KW - paraquat
KW - plant products
KW - residues
KW - techniques
KW - analytical techniques
KW - crop products
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952309649&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transplacental transmission of Wuchereria bancrofti in Haitian women.
AU - Eberhard, M. L.
AU - Hitch, W. L.
AU - McNeeley, D. F.
AU - Lammie, P. J.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1993///
VL - 79
IS - 1
SP - 62
EP - 66
SN - 0022-3395
AD - Eberhard, M. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19930804331. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Helminthology; Tropical Diseases
N2 - To document the occurrence of transplacental transmission of microfilariae and to determine how frequently it occurred, umbilical cord blood samples and placental tissues were collected from 22 microfilaria-positive women in an area [of Haiti] with endemic W. bancrofti infection. Microfilaria (mf) counts in the women ranged from 1 to 3820 mf/ml. Microfilariae were detected in 2 placenta samples and a single cord blood sample. The positive cord blood sample and 1 of the positive placenta samples came from the same woman; no microfilariae were found in a finger prick sample taken from the infant 3 weeks after delivery. [The] results suggest that microfilariae cross the placenta in less than 10% of pregnancies of microfilaria-positive mothers. Furthermore, the microfilaria count of the mother does not seem to influence directly whether microfilariae are present in the placental blood pool. Although actual transfer of microfilariae to the fetus may occur infrequently, exposure to parasite antigens occurs with much greater frequency. The effect of in utero exposure to either microfilariae or parasite antigens may render newborns tolerant and explain why children born to infected mothers are almost 3 times more likely to become infected than are children born to uninfected mothers.\AS<new para>ADDITIONAL ABSTRACT:<new para>To document the occurrence of transplacental transmission of microfilariae and to determine how frequently it occurred, umbilical cord blood samples and placental tissues were collected from 22 microfilaria-positive women in an area of Haiti, endemic for W. bancrofti infection. Microfilaria (mf) counts in the women ranged from 1 to 3820 mf/ml. Microfilariae were detected in 2 placenta samples and a single cord blood sample. The positive cord blood sample and 1 of the positive placenta samples came from the same woman; no microfilariae were found in a finger prick sample taken from the infant 3 weeks after delivery. The results suggest that microfilariae cross the placenta in less than 10% of pregnancies of microfilaria-positive mothers. The microfilariae count of the mother does not seem to influence directly whether microfilariae are present in the placental blood pool. Although actual transfer of microfilariae to the fetus may occur infrequently, exposure to parasite antigens occurs with much greater frequency. The effect of in utero exposure to either microfilariae or parasite antigens may render newborns tolerant and explain why children born to infected mothers are almost 3 times more likely to become infected than are children born to uninfected mothers.
KW - bancroftian filariasis
KW - Developmental stages
KW - disease transmission
KW - epidemiology
KW - filariasis
KW - helminths
KW - Human diseases
KW - Neonates
KW - parasites
KW - transmission
KW - transplacental transmission
KW - Caribbean
KW - Haiti
KW - Pacific Islands
KW - man
KW - Nematoda
KW - Onchocercidae
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Wuchereria
KW - Onchocercidae
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - Oceania
KW - growth phase
KW - nematodes
KW - newborn infants
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930804331&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational injury deaths in Alaska's fishing industry, 1980 through 1988.
AU - Schnitzer, P. G.
AU - Landen, D. D.
AU - Russell, J. C.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993///
VL - 83
IS - 5
SP - 685
EP - 688
SN - 0090-0036
AD - Schnitzer, P. G.: (D.D. Landen) National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch 944 Chestnut Ridge Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19942025206. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Studies from other countries have identified fishing as a hazardous industry, but little is known about occupational injury mortality related to fishing in the United States. Alaska was chosen for this study because approximately 45 000 people annually participate in Alaska's fishing industry and fishing is thought to be a major contributor to occupational injury mortality in the state. Work-related injury deaths in Alaska's fishing industry were identified by means of death certificates and US Coast Guard mortality data. Fatality rates were calculated by using average annual fishing industry employment estimates. The 5-year average annual fishing-related fatality rate was 414.6 per 100 000 fishermen. The majority of the decedents were Caucasian men who drowned while fishing. This study emphasizes that fishing is a dangerous industry in Alaska and demonstrates the benefit of using multiple data sources to identify fishing-related deaths in the state. AS
KW - fishermen
KW - mortality
KW - occupational health
KW - Occupations
KW - Alaska
KW - North America
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942025206&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pathological and immunological effects of ingesting L-tryptophan and 1,1′-ethylidenebis (L-tryptophan) in Lewis rats.
AU - Love, L. A.
AU - Rader, J. I.
AU - Crofford, L. J.
AU - Raybourne, R. B.
AU - Principato, M. A.
AU - Page, S. W.
AU - Trucksess, M. W.
AU - Smith, M. J.
AU - Dugan, E. M.
AU - Turner, M. L.
AU - Zelazowski, E.
AU - Zelazowski, P.
AU - Sternberg, E. M.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 1993///
VL - 91
IS - 3
SP - 804
EP - 811
SN - 0021-9738
AD - Love, L. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, District of Columbia 20204, USA.
N1 - Accession Number: 19941407843. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 73-22-3. Subject Subsets: Human Nutrition
N2 - The pathology associated with treatment of Lewis rats with synthetic 1,1′-ethylidenebis(L-tryptophan) (EBT) and/or L-tryptophan (L-TRP) was investigated. All rats treated for 6 weeks with case-associated L-tryptophan or EBT developed significant myofascial thickening, compared with rats in the vehicle control and control L-TRP groups. However, even those rats receiving the control L-TRP showed a mild but significant increase in the thickness of the myofascia, compared with vehicle-treated controls. All rats except vehicle controls also exhibited significant pancreatic pathology, including fibrosis and acinar changes. Only rats treated with case-associated L-TRP for 6 weeks showed evidence of immune activation with increased frequency of CD8, Ia and IL-2 receptor-positive cells in the peripheral blood. Rats receiving L-TRP or EBT for <6 weeks did not show significant differences in myofascial thickness, although these rats did not show pancreatic acinar changes. Although these results demonstrate for the first time the pathological effects of EBT, they do not rule out the possibility that other impurities in the eosinophilia-myalgia syndrome (EMS)-case-associated L-TRP may also contribute to some of the features of EMS.
KW - derivatives
KW - eosinophilia
KW - fibrosis
KW - immune response
KW - intake
KW - pancreatitis
KW - tryptophan
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immunity reactions
KW - immunological reactions
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941407843&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Height, weight, and body mass index of American Indian schoolchildren, l990-1991.
AU - Jackson, M. Y.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1993///
VL - 93
IS - 10
SP - 1136
EP - 1140
SN - 0002-8223
AD - Jackson, M. Y.: Nutrition and Dietetics Section, Indian Health Service, Rockville, MD 20852, USA.
N1 - Accession Number: 19941404643. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - Data for height, weight and body mass index of 9464 American Indian schoolchildren were compared with 2 national reference data sets, the second National Health and Nutrition Examination Survey (NHANES II) and the Mexican-American population of the Hispanic Health and Nutrition Examination Survey (HHANES-MA). The 3 populations were similar in height, but the American Indian children weighed more (not significant), and had a significantly greater body mass index than in the NHANES II reference population for nearly every age and sex group. The overall prevalence of overweight in the American Indian children (exceeding the 85th percentile of the reference population) was 39.3% compared with the NHANES II population and 28.6% compared with the HHANES-MA population. The overall prevalence of underweight in the American Indian sample was substantially less than the expected 15% compared with the NHANES II or HHANES-MA population. Overweight is much more relevant in American Indian children than among other children in the USA at all ages and both sexes. This may have important implications for chronic disease risk and emphasizes the need for targeting obesity prevention efforts to these children.
KW - American Indians
KW - anthropometric dimensions
KW - body weight
KW - children
KW - diet studies
KW - ethnic groups
KW - height
KW - school children
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anthropometric measurements
KW - school kids
KW - schoolchildren
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941404643&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Osteolytic phaeohyphomycosis caused by Phialemonium obovatum.
AU - Magnon, K. C.
AU - Jalbert, M.
AU - Padhye, A. A.
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
Y1 - 1993///
VL - 117
IS - 8
SP - 841
EP - 843
SN - 0003-9985
AD - Magnon, K. C.: A. A. Padhye, Mycotic Diseases Branch, Department of Health and Human Services, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19941200831. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - A case is reported in a 41-y-old man from Texas, USA, who presented with worsening lower back pain 17 months after a non-penetrating injury to his lumbar and cervical region. Magnetic resonance imaging 6 months previously had revealed a herniated disc at C5-6 and was suggestive of discitis and osteomyelitis at L3-4. At presentation, lumbar spine roentgenograms showed a destructive process at L-3. An L3-4 left-sided hemilaminectomy was performed and cultures of ground tissue grew P. obovatum on biphasic brain-heart infusion medium. Colonies were moist, off-white to ochraceous with a characteristic green, diffusible pigment on the reverse side. The isolate grew well up to 40°C. It formed characteristic adelophialides without conspicuous collarettes and basal septa and produced smooth, one-celled, hyaline and obvate conidia. The infection was confirmed by the demonstration of replicating fungal elements in the disc tissue. Since there had been no open wound at any time during the patient's illness it was concluded that the organism had been unintentionally inoculated into the patient at the time of injection for a radiological study.
KW - bones
KW - case reports
KW - nosocomial infections
KW - osteomyelitis
KW - phaeohyphomycosis
KW - spine
KW - Texas
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Cephalothecaceae
KW - Sordariales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - chromomycosis
KW - fungus
KW - hospital infections
KW - Hyphomycetes
KW - mitosporic fungi
KW - Phialemonium
KW - Phialemonium obovatum
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941200831&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quality of laboratory performance in testing for human immunodeficiency virus type 1 antibody: identification of variables associated with laboratory performance.
AU - Hancock, J. S.
AU - Taylor, R. N.
AU - Johnson, C. A.
AU - Gerber, A. R.
AU - Schalla, W. O.
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
Y1 - 1993///
VL - 117
IS - 11
SP - 1148
EP - 1155
SN - 0003-9985
AD - Hancock, J. S.: Laboratory Practice Assessment Branch, Division of Laboratory Systems, Public Health Practice Program Office, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA. (No reprints).
N1 - Accession Number: 19942005316. Publication Type: Journal Article. Language: English.
KW - ELISA
KW - HIV infections
KW - Immunodiagnosis
KW - quality controls
KW - Serology
KW - western blotting
KW - enzyme linked immunosorbent assay
KW - human immunodeficiency virus infections
KW - quality assurance
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005316&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary phosphorus, calcium metabolism and bone.
AU - Calvo, M. S.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1993///
VL - 123
IS - 9
SP - 1627
EP - 1633
SN - 0022-3166
AD - Calvo, M. S.: Center for Food Safety and Applied Nutrition, HFS-226, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941401575. Publication Type: Journal Article. Language: English. Number of References: 59 refs. Registry Number: 7440-70-2, 7723-14-0. Subject Subsets: Human Nutrition
N2 - Evidence on the relation of calcium and phosphorus intakes of teenagers and young adults to the development of lower peak bone mass is reviewed.
KW - adolescents
KW - bone density
KW - bones
KW - calcium
KW - children
KW - intake
KW - metabolism
KW - osteoporosis
KW - phosphorus
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - teenagers
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941401575&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Coconut oil and sesame oil affect lymphatic absorption of cholesterol and fatty acids in rats.
AU - Satchithanandam, S.
AU - Reicks, M.
AU - Calvert, R. J.
AU - Cassidy, M. M.
AU - Kritchevsky, D.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1993///
VL - 123
IS - 11
SP - 1852
EP - 1858
SN - 0022-3166
AD - Satchithanandam, S.: U.S. Food and Drug Administration, Division of Nutrition, Laurel, MD 20708, USA.
N1 - Accession Number: 19941402027. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 57-88-5, 8008-74-0. Subject Subsets: Human Nutrition
N2 - 5 groups of male Wistar rats weighing about 200 g consumed 12 or 24% sesame or coconut oil diets or a control diet (14% maize oil) freely for 4 weeks. Thoracic ducts were cannulated and a lipid emulsion containing [³H]cholesterol and [14C]oleic acid was given through a duodenal catheter. Lymph was collected for 24 h and the isotopic tracers for cholesterol and fatty acids were measured. Rats fed on the 24% sesame oil diet had significantly lower lymphatic cholesterol and fatty acid compared with controls. Absorption of oleic acid in rats fed on 24% coconut oil was significantly greater than controls during 0-8 h but was not significantly different during 0-24 h. There were no differences among groups in distribution of cholesterol and oleic acid in lymph lipoproteins or in lipid classes. It is concluded that the significant reduction in lymph cholesterol and fatty acids due to sesame oil feeding may be an important factor in reducing hypercholesterolaemia.
KW - cholesterol
KW - coconut oil
KW - fatty acids
KW - hypercholesterolaemia
KW - intake
KW - lipids
KW - lymph
KW - sesame oil
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hypercholesterinemia
KW - hypercholesterolemia
KW - lipins
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402027&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Starches of varied digestibilities differentially modify intestinal function in rats.
AU - Lajvardi, A.
AU - Mazarin, G. I.
AU - Gillespie, M. B.
AU - Satchithanandam, S.
AU - Calvert, R. J.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1993///
VL - 123
IS - 12
SP - 2059
EP - 2066
SN - 0022-3166
AD - Lajvardi, A.: US Food and Drug Administration, Division of Nutrition, MOD-1, HFS-451, Laurel, MD 20708, USA.
N1 - Accession Number: 19941402045. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9005-25-8. Subject Subsets: Human Nutrition; Potatoes
N2 - Male Fischer 344 rats were fed on diets containing 25% cooked potato starch, arrowroot starch, high amylose maize starch or raw potato starch for 6 weeks. Faecal weight, transit time, colonic thymidine kinase activity (a marker for cell proliferation) and weight, starch content and pH of the caecum and proximal and distal colon were measured. Raw potato starch was much less completely digested than high amylose maize starch, resulting in a 32-fold greater amount of undigested starch entering the caecum in the raw potato starch group. High amylose maize starch and raw potato starch diets significantly enhanced faecal weight and produced large intestinal hypertrophy, effects that were greatest in the raw potato starch group. Raw potato starch feeding was associated with the highest level of thymidine kinase activity, although differences in thymidine kinase activity among the groups were not significant. This diet also produced a 50% longer transit time. Entry of a large amount of raw potato starch into the colon resulted in greater luminal acidity, greater luminal bulk and slower transit. A much smaller amount of starch entered the colon in the high amylose maize starch group and resulted in faecal bulking but no alteration in transit.
KW - caecum
KW - carcinogenesis
KW - cell growth
KW - colon
KW - digestibility
KW - faeces composition
KW - intake
KW - nutrition
KW - pH
KW - risk
KW - sources
KW - starch
KW - transit time
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cecum
KW - cell elongation
KW - feces composition
KW - hydrogen ion concentration
KW - potential of hydrogen
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941402045&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selection and partial characterization of dengue 2 virus mutants that induce fusion at elevated pH.
AU - Guirakhoo, F.
AU - Hunt, A. R.
AU - Lewis, J. G.
AU - Roehrig, J. T.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1993///
VL - 194
IS - 1
SP - 219
EP - 223
SN - 0042-6822
AD - Guirakhoo, F.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950507590. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 12125-02-9.
N2 - Two types of dengue (DEN) 2 virus mutants were selected either by repeated exposure to acidic pH (acid mutant, AM), or by the addition of ammonium chloride to Aedes albopictus C6/36 cells prior to and during viral infection (fusion mutant, FM). Both mutants grew more slowly than the parent strain and induced smaller plaques in Vero cells. The 50% fusion from within index for both mutants occurred at least 0.65 pH units higher than with the wild-type DEN virus. A single amino acid substitution (Asn-153 to Asp) was found in the envelope (E)-glycoprotein of the AM virus. 3 amino acid substitutions were detected on the E-glycoprotein of the FM virus: Ile-6 to Met, Asn-134 to Ser, and Asn-153 to Tyr. No mutations were found in the precursor to the membrane protein, prM. The DEN virus E-glycoprotein has 2 potential glycosylation sites: Asn-67 and Asn-153. The loss of the potential glycosylation site at Asn-153 or the change in the chemical characteristics resulting from the amino acid substitutions in both mutants implicates these regions of the E-glycoprotein in virus-mediated membrane fusion.
KW - amino acids
KW - ammonium chloride
KW - arboviruses
KW - characterization
KW - mutants
KW - pH
KW - viral proteins
KW - Aedes albopictus
KW - Culicidae
KW - dengue 2 virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - ammonium hydrochloride
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - fusion
KW - hydrogen ion concentration
KW - mosquitoes
KW - potential of hydrogen
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507590&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phylogenetic relationships of dengue-2 viruses.
AU - Lewis, J. A.
AU - Chang GwongJen
AU - Lanciotti, R. S.
AU - Kinney, R. M.
AU - Mayer, L. W.
AU - Trent, D. W.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1993///
VL - 197
IS - 1
SP - 216
EP - 224
SN - 0042-6822
AD - Lewis, J. A.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950506357. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - RNA oligonucleotide fingerprinting studies on a large number of virus isolates previously demonstrated considerable genetic variation in isolates of dengue (DEN-)-2 serotype. The entire envelope (E) glycoprotein gene and deduced amino acid sequences of 16 DEN-2 viruses and the phylogenetic relationships of these, plus 17 additional published DEN E gene sequences are reported. Comparison of DEN-2 E glycoprotein gene sequences revealed base substitutions scattered throughout the entire gene with as much as 22% sequence divergence. Aligned E glycoprotein amino acid sequences revealed that the viruses differed by as much as 10%. There appeared to be constraints on the overall structure of the E protein to maintain biological function. Clusters of amino acid substitutions were present in the hydrophobic membrane anchor region at the carboxyl terminal end of the protein. Maximum parsimony analysis of the E gene sequences allowed construction of a phylogram indicating evolutionary relationships of the virus isolates within the DEN-2 serotype. Five genetic subtypes were identified. Phylogenetic relationships of the DEN-2 serotype and other flaviviruses based on E protein sequences reflected traditional antigenic and serologic classifications.
KW - amino acid sequences
KW - arboviruses
KW - evolution
KW - phylogeny
KW - dengue 2 virus
KW - dengue virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950506357&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Increased expression of α4β1 and α5β1 integrins on HTLV-I-infected lymphocytes.
AU - Dhawan, S.
AU - Weeks, B. S.
AU - Abbasi, F.
AU - Gralnick, H. R.
AU - Notkins, A. L.
AU - Klotman, M. E.
AU - Yamada, K. M.
AU - Klotman, P. E.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1993///
VL - 197
IS - 2
SP - 778
EP - 781
SN - 0042-6822
AD - Dhawan, S.: Laboratory of Molecular Virology, Food and Drug Administration, Rockville, Maryland 20852, USA.
N1 - Accession Number: 19952009614. Publication Type: Journal Article. Language: English. Number of References: 32 ref.
N2 - T cells interact with the extracellular matrix via integrin receptors and these interactions affect both cellular localization and proliferation. The importance of these interactions in retrovirus-induced diseases, however, remains less clear. In the present study, the authors investigated changes in T cell adhesion to extracellular matrix proteins by HTLV-I expressing cell lines and human peripheral blood lymphocytes infected with HTLV-I by cocultivation. Cell lines and acutely infected primary peripheral blood lymphocytes demonstrated enhanced adhesion to fibronectin. Acute infection of peripheral blood lymphocytes increased the expression of α5β1 and α4β1 integrins. Antibodies to the α4, α5, and β1 subunits inhibited attachment of infected cells to fibronectin. The authors conclude that HTLV-I infection is associated with an increase in the expression of both the classical fibronectin receptor and the receptor for the alternatively spliced domain of fibronectin on peripheral blood lymphocytes. HTLV-I-related alterations in cell surface adhesion molecules may contribute to the abnormal proliferation of T cells in adult T cell leukaemia (ATL) or to the abnormal localization of activated or infected T cells to the central nervous system of patients with tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM).
KW - human diseases
KW - lymphocytes
KW - tropical spastic paraparesis
KW - Deltaretrovirus
KW - human t-cell lymphotropic virus type i
KW - man
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Human T-cell lymphotropic virus
KW - Deltaretrovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - HTLV-BLV group
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009614&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of the receptor-binding domain of tetanus toxin.
AU - Halpern, J. L.
AU - Loftus, A.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1993///
VL - 268
IS - 15
SP - 11188
EP - 11192
SN - 0021-9258
AD - Halpern, J. L.: Food and Drug Administration, Bldg. 29, Rm. 103, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19932022738. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - toxins
KW - Clostridium tetani
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - receptor-binding domain
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932022738&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Actual causes of death in the United States.
AU - McGinnis, J. M.
AU - Foege, W. H.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1993///
VL - 270
IS - 18
SP - 2207
EP - 2212
SN - 0098-7484
AD - McGinnis, J. M.: Disease Prevention and Health Promotion, US Department of Health and Human Services, 330 C St SW, Room 2132, Washington, DC 20201, USA.
N1 - Accession Number: 19942005326. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - ... The most prominent contributors to mortality in the United States in 1990 were tobacco (an estimated 400 000 deaths), diet and activity patterns (300 000), alcohol (100 000), microbial agents (90 000), toxic agents (60 000), firearms (35 000), sexual behaviour (30 000), motor vehicles (25 000), and illicit use of drugs (20 000). Socioeconomic status and access to medical care are also important contributors, but difficult to quantify independent of the other factors cited. Because the studies reviewed used different approaches to derive estimates, the stated numbers should be viewed as first approximations. Approximately half of all deaths that occurred in 1990 could be attributed to the factors identified. Although no attempt was made to further quantify the impact of these factors on morbidity and quality of life, the public health burden they impose is considerable and offers guidance for shaping health policy priorities. AS
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Epidemiology
KW - HIV infections
KW - Mortality
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - AIDS
KW - causes
KW - death rate
KW - human immunodeficiency virus infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005326&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Detecting and biotyping Vibrio cholerae O1 with multiplex polymerase chain reaction.
AU - Keasler, S. P.
AU - Hall, R. H.
T2 - Lancet (British edition)
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1993///
VL - 341
SP - 1661
EP - 1661
SN - 0140-6736
AD - Keasler, S. P.: Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19932023898. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health
KW - detection
KW - polymerase chain reaction
KW - Vibrio cholerae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - O1 type
KW - PCR
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19932023898&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Non-01 Vibrio cholerae.
AU - Hall, R. H.
AU - Khambaty, F. M.
AU - Kothary, M.
AU - Keasler, S. P.
T2 - Lancet (British edition)
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1993///
VL - 342
IS - 8868
SP - 430
EP - 430
SN - 0140-6736
AD - Hall, R. H.: Food and Drug Administration, Washington DC 20204, USA.
N1 - Accession Number: 19952007377. Publication Type: Correspondence. Language: English. Number of References: 5 ref.
KW - cholera
KW - diarrhoea
KW - dna amplification
KW - epidemics
KW - epidemiology
KW - human diseases
KW - molecular biology
KW - outbreaks
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - restriction mapping
KW - serological surveys
KW - India
KW - man
KW - Vibrio cholerae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - bacterium
KW - diarrhea
KW - PCR
KW - RFLP
KW - scouring
KW - seroepidemiology
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952007377&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The absence of a synergistic protective effect of β-carotene and vitamin E on skin tumorigenesis in mice.
AU - Lambert, L. A.
AU - Wamer, W. G.
AU - Wei, R. R.
AU - Lavu, S.
AU - Kornhauser, A.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1993///
VL - 691
SP - 259
EP - 261
SN - 0077-8923
AD - Lambert, L. A.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-128, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941405517. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref. Registry Number: 7235-40-7, 1406-18-4. Subject Subsets: Human Nutrition
KW - beta-carotene
KW - carcinogenesis
KW - intake
KW - prevention
KW - skin
KW - vitamin E
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dermis
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Carotene uptake, metabolism, and distribution in vitro.
AU - Wamer, W. G.
AU - Wei, R. R.
AU - Matusik, J. E.
AU - Kornhauser, A.
AU - Dunkel, V. C.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1993///
VL - 691
SP - 284
EP - 286
SN - 0077-8923
AD - Wamer, W. G.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-128, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941405526. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 2 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
KW - beta-carotene
KW - cell cultures
KW - characterization
KW - distribution
KW - fibroblasts
KW - metabolism
KW - uptake
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941405526&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological characterization and serological identification of Bacillus cereus diarrhoeal factor.
AU - Bennett, R. W.
AU - Murthy, G.
AU - Kaylor, L.
AU - Cox, S.
AU - Harmon, S. M.
JO - Bulletin of the International Dairy Federation
JF - Bulletin of the International Dairy Federation
Y1 - 1993///
IS - 287
SP - 30
EP - 37
SN - 0250-5118
AD - Bennett, R. W.: Center for Food Safety and Applied Nurition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19940400863. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - Bacillus cereus is associated with 2 distinct types of foodborne illness, diarrhoeal and emetic, which are caused by 2 toxins produced by the bacterium. The symptoms of these toxins are similar to those of other foodborne toxins, therefore they must be identified in suspect foods. The bacterial antigen associated with toxic diarrhoea was identified and characterized. Selected extracellular proteins of the bacterium (antigens 573, 577 and 580, cereolysin, and secondary haemolysins from several strains of B. cereus, including B4ac) were identified serologically and given by mouth to monkeys (Macaca fascicularis) in crude form or partially purified through Amberlite resin CG400. Monkeys given crude or partially purified preparations of antigen 577 suffered diarrhoea (crude, 13 of 15; partially purified, 4 of 5) after receiving ≥250 arbitrary units (1 unit corresponds to 1 ml preparation with a titre of 1 or, e.g., 1 µl of titre 1000). However, comparable preparations chromatographed on diethylaminoethylcellulose (DEAE) caused no diarrhoea (0 of 9). Therefore the DEAE must have destabilized or inactivated the toxin. Preparations lacking antigen 577 but containing the other antigens caused no diarrhoea. Crude or partially purified antigen 577 neutralized with a serum against 577 caused no significant diarrhoea (1 of 12). A monospecific serum against 577 has been prepared for identification of the diarrhoeal toxin produced by Bacillus spp., including B. cereus in culture media and foods.
KW - antigens
KW - characterization
KW - cows
KW - enterotoxins
KW - Bacillus cereus
KW - cattle
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - Bacillus cereus in milk and milk products
KW - bacterium
KW - immunogens
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940400863&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Involving consumers in food control in the United States.
AU - Guilford, C. T.
JO - Food, Nutrition and Agriculture
JF - Food, Nutrition and Agriculture
Y1 - 1993///
IS - 8/9
SP - 32
EP - 37
SN - 1014-806X
AD - Guilford, C. T.: Consumer Affairs and Information Staff, Office of Regulatory Affairs, United States Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19951412427. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Subject Subsets: Human Nutrition
KW - consumers
KW - food legislation
KW - food safety
KW - organizations
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412427&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The historical road to the discovery of Borrelia burgdorferi.
AU - Burgdorfer, W.
A2 - Weber, K.
A2 - Burgdorfer, W.
T2 - Aspects of Lyme borreliosis.
JO - Aspects of Lyme borreliosis.
JF - Aspects of Lyme borreliosis.
Y1 - 1993///
SP - 21
EP - 28
CY - Berlin; Germany
PB - Springer-Verlag
SN - 3540556281\0387556281
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Hamilton, MT 59840, USA.
N1 - Accession Number: 19930517483. Publication Type: Miscellaneous. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Entomology
KW - history
KW - Human diseases
KW - Lyme disease
KW - research
KW - Tickborne diseases
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Spirochaetaceae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - lyme borreliosis
KW - studies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Research (AA500)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19930517483&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effects of β-carotene and related carotenoids on vitamin E.
AU - Blakely, S. R.
AU - Mitchell, G. V.
AU - Jenkins, M. L. Y.
AU - Grundel, E.
A2 - Packer, L.
A2 - Fuchs, J.
T2 - Vitamin E in health and disease.
JO - Vitamin E in health and disease.
JF - Vitamin E in health and disease.
Y1 - 1993///
SP - 63
EP - 68
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824786920
AD - Blakely, S. R.: United States Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19931462145. Publication Type: Miscellaneous. Language: English. Number of References: 21 ref. Registry Number: 7235-40-7, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Studies in animals and man that involve interaction of β-carotene and related carotenoids with vitamin E are reviewed. β-Carotene, because of its conversion to vitamin A, may exhibit an indirect effect on vitamin E by enhancing the concentration of vitamin A in the body. These and other factors that influence the effects of carotenoids on vitamin E are discussed.
KW - beta-carotene
KW - carotenoids
KW - interactions
KW - Laboratory animals
KW - reviews
KW - Vitamin E
KW - Man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - tetraterpenoids
KW - Laboratory Animal Science (LL040)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19931462145&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Surveillance and surveys for cystic echinococcosis.
AU - Schantz, P. M.
A2 - Andersen, F. L.
A2 - Chai, J. J.
A2 - Liu, F. J.
T2 - Compendium on cystic echinococcosis: with special reference to the Xinjiang Uygur Autonomous Region, The People's Republic of China.
JO - Compendium on cystic echinococcosis: with special reference to the Xinjiang Uygur Autonomous Region, The People's Republic of China.
JF - Compendium on cystic echinococcosis: with special reference to the Xinjiang Uygur Autonomous Region, The People's Republic of China.
Y1 - 1993///
SP - 74
EP - 84
CY - Provo; USA
PB - Brigham Young University
AD - Schantz, P. M.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950805887. Publication Type: Miscellaneous. Language: English. Number of References: 48 ref. Subject Subsets: Veterinary Science; Helminthology
N2 - This review discusses methods for determining indices of Echinococcus granulosus infection in man, livestock, and dogs, and lists other types of information that are considered important to the comprehensive surveillance of hydatid disease. Hospital registries of diagnosed cases remain the most common and useful method of surveillance of human infection. Ultrasound imaging of the abdomen with portable equipment is the recommended diagnostic method for surveys and screening; immunological tests are relatively insensitive and nonspecific for this purpose. Obtaining data during inspection of livestock at slaughter remains the most practical method for monitoring infection in intermediate hosts. Examining the intestines at autopsy and inspecting purged faecal specimens are the most widely used methods for diagnosing Echinococcus infections in dogs. However, recent advances in immunodiagnostic methods, particularly detecting antigens in faecal specimens, may ultimately replace the older, more laborious procedures. The necessity for achieving a good working collaboration between human and animal health authorities is emphasized.
KW - diagnosis
KW - disease prevalence
KW - epidemiology
KW - helminths
KW - human diseases
KW - immunodiagnosis
KW - livestock
KW - metacestodes
KW - parasites
KW - reviews
KW - surveillance
KW - Canidae
KW - carnivores
KW - Cestoda
KW - dogs
KW - Echinococcus
KW - Echinococcus granulosus
KW - man
KW - Taeniidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Platyhelminthes
KW - invertebrates
KW - Canis
KW - Canidae
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Echinococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - parasitic worms
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Taxonomy of viruses of the family Rhabdoviridae.
AU - Calisher, C. H.
A2 - St George, T.D.
A2 - Uren, M.F.
A2 - Young, P.L.
A2 - Hoffmann, D.
T2 - Bovine ephemeral fever and related rhabdoviruses: Proceedings of the 1st International Symposium, Beijing, PRC, 25-27 August 1992.
JO - Bovine ephemeral fever and related rhabdoviruses: Proceedings of the 1st International Symposium, Beijing, PRC, 25-27 August 1992.
JF - Bovine ephemeral fever and related rhabdoviruses: Proceedings of the 1st International Symposium, Beijing, PRC, 25-27 August 1992.
Y1 - 1993///
SP - 77
EP - 79
CY - Canberra; Australia
PB - Australian Centre for International Agricultural Research (ACIAR)
AD - Calisher, C. H.: WHO Collaborating Center for Arbovirus Reference and Research, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950507408. Publication Type: Conference paper. Language: English. Number of References: 7 ref.
N2 - The International Committee on Taxonomy of Viruses recently endorsed a recommendation to introduce the taxonomic category 'order' into virus classification. The first families of viruses so placed are in the order Mononegavirales (families Rhabdoviridae, Filoviridae and Paramyxoviridae) which include viruses such as Newcastle disease, mumps, respiratory syncytial, measles and Ebola viruses, as well as rabies, bovine ephemeral fever and vesicular stomatitis viruses. Of 92 non-plant rhabdoviruses infecting vertebrates and invertebrates, 20 have been placed in the genus Vesiculovirus, 26 in the genus Lyssavirus and 46 have not been placed in either genus. This paper describes the molecular, antigenic and biological characteristics of viruses of the family Rhabdoviridae with emphasis on viruses of the genus Lyssavirus related to bovine ephemeral fever virus.
KW - arboviruses
KW - classification
KW - nomenclature
KW - taxonomy
KW - bovine ephemeral fever virus
KW - Lyssavirus
KW - Mononegavirales
KW - Rhabdoviridae
KW - Vesiculovirus
KW - viruses
KW - Ephemerovirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - systematics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Control measures in shellfish and finfish industries in the USA.
AU - Hungerford, J. M.
AU - Wekell, M. M.
A2 - Falconer, I. R.
T2 - Algal toxins in seafood and drinking water.
JO - Algal toxins in seafood and drinking water.
JF - Algal toxins in seafood and drinking water.
Y1 - 1993///
SP - 117
EP - 128
CY - London; UK
PB - Academic Press
SN - 0122479904
AD - Hungerford, J. M.: Seafood Products Research Center, US Food and Drug Administration, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19941408502. Publication Type: Miscellaneous. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
KW - diarrhoea
KW - fish industry
KW - fish toxins
KW - food poisoning
KW - marine environment
KW - marine fishes
KW - paralysis
KW - quality controls
KW - shellfish
KW - toxins
KW - USA
KW - fishes
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - diarrhea
KW - quality assurance
KW - scouring
KW - sea fishes
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Aquatic Produce (QQ060)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Food Industry (EE520) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Forum: Perspectives on the environmental management of ticks and Lyme disease.
AU - Piesman, J.
AU - Korch, G. W., Jr.
AU - Telford, S. R., III
AU - Falco, R. C.
AU - Daniels, T. J.
AU - Mount, G. A.
AU - Sonenshine, D. E.
AU - Stafford, K. C., III
A2 - Ginsberg, H.S.
T2 - Ecology and environmental management of Lyme disease.
JO - Ecology and environmental management of Lyme disease.
JF - Ecology and environmental management of Lyme disease.
Y1 - 1993///
SP - 157
EP - 182
CY - New Brunswick, NJ; USA
PB - Rutgers University Press
SN - 0813519284
AD - Piesman, J.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control, US Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19960500040. Publication Type: Miscellaneous. Language: English.
N2 - Officials and citizens anxious to prevent Lyme disease inevitably ask: "How can we control the ticks, or the deer, or the mice? ". And they find it hard to sort out which of the wide - and often confusing - range of proposed techniques male most sense for their local situation. In a previous chapter of this book, M.L. Wilson & R.D. Deblinger discussed the ecological principles that underlie the answers to that critical environmental management question. In this Forum, 8 researchers comment on that chapter and offer additional perspectives and data from their own work. Their remarks emphasize the importance of understanding the particular piece of land - whether it be a single house's lawn or a large state park - and the interactions of people with Lyme disease vectors in that place and its surroundings. No single answer can work everywhere and for everyone (although everyone should heed the importance of personal-protection methods against tick attachment). By coupling Wilson & Deblinger's overview with the insights and results of the Forum contributors, readers can see what solutions are likely to fit their particular circumstances and why.
KW - disease control
KW - disease vectors
KW - environmental management
KW - reservoir hosts
KW - vector control
KW - wild animals
KW - zoonoses
KW - USA
KW - Borrelia burgdorferi
KW - Ixodes
KW - Ixodes scapularis
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal reservoirs
KW - bacterium
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - A retrospective analysis of drug residues in food producing animals in the United States for 1990 and 1991.
AU - Mitchell, D. A.
AU - Paige, J. C.
A2 - Ingkaninun, P.
A2 - Poomvises, P.
T2 - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
JO - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
JF - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
Y1 - 1993///
SP - 258
EP - 260
CY - Bangkok; Thailand
PB - World Association of Veterinary Food Hygienists (WAVFH)
SN - 9745833517
AD - Mitchell, D. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19952221039. Publication Type: Conference paper. Language: English. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2 - As a result of structured residue testing programmes, Food and Drug Administration (FDA) and State follow-up and training initiatives and producer-initiated residue control programmes, the USA is experiencing a reduction in the number of animals carrying illegal drug residues. It is stressed that the efforts of the FDA, USDA, States, producer organisations should continue towards the goal of further reducing or eliminating illegal drug residues. Cull dairy cows and veal calves represent the animal populations with the highest risk of harbouring drug residues when presented for slaughter, because the proper withdrawal period has not been calculated.
KW - calf diseases
KW - calves
KW - cows
KW - drug residues
KW - drugs
KW - legislation
KW - meat
KW - meat animals
KW - poultry
KW - USA
KW - cattle
KW - pigs
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - domesticated birds
KW - hogs
KW - medicines
KW - pharmaceuticals
KW - swine
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - An analysis of drug residues in milk in the U.S. as reported from the National Drug Residue Milk Monitoring Program.
AU - Mitchell, G. A.
AU - Kandra, K. A.
AU - McChesney, D. G.
A2 - Ingkaninun, P.
A2 - Poomvises, P.
T2 - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
JO - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
JF - Proceedings, 11th International Symposium of the World Association of Veterinary Food Hygienists, 24-29 October 1993, Bangkok, Thailand.
Y1 - 1993///
SP - 261
EP - 263
CY - Bangkok; Thailand
PB - World Association of Veterinary Food Hygienists (WAVFH)
SN - 9745833517
AD - Mitchell, G. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19952221040. Publication Type: Conference paper. Language: English. Subject Subsets: Veterinary Science
N2 - The likelihood of an illegal antibiotic drug residue in milk in the USA is very small. The Food and Drug Administration believes that the trace back of residues detected through the National Drug Residue Milk Monitoring programme, enforcement of the fines provisions, and the establishment of a national drug residues database will further reduce the small number of positive samples. This will provide an even greater degree of safety for the consumer.
KW - drug residues
KW - drugs
KW - legislation
KW - meat animals
KW - milk
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Recent methods of analysis for aflatoxins in foods and feeds.
AU - Trucksess, M. W.
AU - Wood, G. E.
A2 - Eaton, D. L.
A2 - Groopman, J. D.
T2 - The toxicology of aflatoxins: human health, veterinary and agricultural significance.
Y1 - 1993///
CY - San Diego; USA
PB - Academic Press
SN - 0122282558
AD - Trucksess, M. W.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington DC 20204, USA.
N1 - Accession Number: 19951201859. Publication Type: Book chapter. Language: English. Number of References: 97 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Postharvest Research
N2 - Methods for the quantification of aflatoxins in foods and feeds are discussed, including sampling, sample preparation, solid-phase extraction, thin-layer chromatography, liquid chromatography and immunochemistry. Methods for aflatoxin M1 determination in milk and milk products, confirmation of aflatoxin identity, automation of procedures and safety issues in the handling of mouldy grains and aflatoxins are also considered.
KW - aflatoxins
KW - analytical methods
KW - determination
KW - feeds
KW - foods
KW - immunochemistry
KW - liquid chromatography
KW - milk
KW - milk products
KW - mycotoxins
KW - sampling
KW - thin layer chromatography
KW - analytical techniques
KW - dairy products
KW - feeding stuffs
KW - fungal toxins
KW - sampling techniques
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - IXth International Conference on AIDS in affiliation with the IVth STD World Congress.
AU - Bockstahler, L. E.
AU - Fujimura, R. K.
AU - Lightfoote, M. M.
JO - Clinical and Diagnostic Virology
JF - Clinical and Diagnostic Virology
Y1 - 1994///
VL - 1
IS - 5,6
SP - 343
EP - 350
SN - 0928-0197
AD - Bockstahler, L. E.: Molecular Biology Branch, Division of Life Sciences, OST, CDRH, US Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19942006494. Publication Type: Journal Article; Conference paper; Journal article. Language: English.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - HIV infections
KW - Immunology
KW - Immunotherapy
KW - Pathogenesis
KW - Treatment
KW - AIDS
KW - human immunodeficiency virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human herpesvirus-6-associated malignant lymphoma in a bone marrow transplant recipient.
AU - Razzaque, A.
AU - Knox, K. K.
AU - Carrigan, D. R.
AU - Varricchio, F.
JO - Clinical and Diagnostic Virology
JF - Clinical and Diagnostic Virology
Y1 - 1994///
VL - 2
IS - 4/5
SP - 305
EP - 311
SN - 0928-0197
AD - Razzaque, A.: Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952001521. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Human herpesvirus-6 (HHV-6), the sixth member of the herpesvirus family, can infect and replicate in human haematopoetic cell lines and can cause various illnesses in humans. HHV-6 has been suggested to be linked to various lymphoproliferative disorders. In vitro studies have demonstrated the oncogenic potential of HHV-6. The role of HHV-6 in human lymphomas needs to be examined. To determine the involvement of HHV-6 in an immunoblastic lymphoma which developed in a bone marrow transplant patient, who had HHV-6 viraemia, paraffin-embedded lymphoma tissues were examined for the presence of HHV-6 by immunohistochemistry, PCR and in situ hybridization. This is a case report investigation. An acute myelogenous leukaemia patient received an allogeneic bone marrow transplant. He developed human herpesvirus-6 (HHV-6) viraemia approximately 6 weeks after transplantation and HHV-6 was concurrently isolated from his bone marrow. Soon afterward, a large cell immunoblastic lymphoma was diagnosed. Complications of this tumour subsequently resulted in the patient's death. Periaortic lymph nodes and tumour cells infiltrating the liver and kidneys showed the presence of HHV-6 by immunohistochemistry and polymerase chain reaction (PCR). Southern blot analysis of the PCR amplified DNAs confirmed the presence of transforming pZVH14 DNA sequences of HHV-6 in the tumour tissues. Lymph nodes of 6 immunologically intact individuals were negative for HHV-6 by immunohistochemistry and PCR analysis. Tumour tissues were negative for EBV DNA by in situ hybridization with DNA probes specific for the EBV EBER RNAs. The data suggest that HHV-6 may be involved in the pathogenesis of some immunoblastic lymphomas.
KW - bone marrow transplant
KW - human diseases
KW - lymphoma
KW - neoplasms
KW - North America
KW - USA
KW - human herpesvirus 6
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Roseolovirus
KW - Betaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - cancers
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diagnosis of HIV infection and the polymerase chain reaction (PCR).
AU - Schochetman, G.
AU - Sninsky, J. J.
JO - Applied Virology Research
JF - Applied Virology Research
Y1 - 1994///
VL - 3
SP - 11
EP - 31
AD - Schochetman, G.: Division of HIV/AIDS, Centers for Disease Control and Prevention, United States Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19952003528. Publication Type: Journal Article. Language: English. Number of References: 71 ref.
KW - acquired immune deficiency syndrome
KW - assays
KW - children
KW - diagnosis
KW - drug resistance
KW - HIV infections
KW - human diseases
KW - polymerase chain reaction
KW - western blotting
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - human immunodeficiency virus infections
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational injury deaths among females: the US experience for the decade 1980 to 1989.
AU - Jenkins, E. L.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 1994///
VL - 4
IS - 2
SP - 146
EP - 151
SN - 1047-2797
AD - Jenkins, E. L.: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 19952008393. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - From 1980 through 1989, females accounted for 44% of the total employed population. Thus, occupational safety and health issues specific to the experience of women merit consideration. Research has demonstrated that the occupational fatality experience of females is not adequately described by the group of all workers. The leading cause of death for all workers is motor vehicle incidents, while the leading cause of occupational injury death of females is homicide. The National Institute for Occupational Safety and Health (NIOSH) has compiled a decade of data on the fatal occupational injury experience of US workers, providing a sufficient number of female cases to allow separate analyses. Over the decade, 3821 females died as a result of injuries sustained at work, with an average annual fatality rate of 0.82/100 000 female workers. Among industries, retail trade and services accounted for nearly half of all occupational injury deaths to females. The detailed occupations with the highest rates of work-related injury death were aeroplane pilots and navigators, drivers of heavy trucks, construction labourers, and police and detectives. Information on the causes of work-related injury death by occupation is fundamental to the prevention of these deaths. The causes of death in the highest-risk occupations included aircraft crashes, motor vehicle collisions, pedestrians struck by motor vehicles, and homicides by firearms. These data provide a foundation for the prevention of occupational injury deaths among females in the USA.
KW - mortality
KW - occupational hazards
KW - occupations
KW - women
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - death rate
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Women (UU500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunologic escape as a mechanism of viral persistence in HIV-1 infection.
AU - McNicholl, J. M.
AU - McDougal, S.
JO - Seminars in Virology
JF - Seminars in Virology
Y1 - 1994///
VL - 5
IS - 4
SP - 307
EP - 317
SN - 1044-5773
AD - McNicholl, J. M.: MS-A25, Immunology Branch, Division of HIV/AIDS, National Center for Infectious Disease, Centers for Disease Control and Prevention, US Department of Health and Human Services, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19962000862. Publication Type: Journal Article. Language: English.
KW - cytotoxic T lymphocytes
KW - cytotoxicity
KW - genetic variation
KW - human immunodeficiency viruses
KW - immune response
KW - immunology
KW - neutralization
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - human immunodeficiency virus
KW - immunity reactions
KW - immunological reactions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of antibody to the human immunodeficiency virus among clinical laboratory specimens: findings from a survey of primary care physicians.
AU - Fernando, N. H.
AU - Petersen, L. R.
AU - Conway, G. A.
AU - Critchley, S. E.
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
Y1 - 1994///
VL - 7
IS - 2
SP - 177
EP - 181
SN - 0894-9255
AD - Fernando, N. H.: (L.R. Petersen) Division of HIV/AIDS, Mailstop E46, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Resources, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942005762. Publication Type: Journal Article. Language: English.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - HIV infections
KW - Safety
KW - serological surveys
KW - AIDS
KW - human immunodeficiency virus infections
KW - Laboratory specimens
KW - seroepidemiology
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942005762&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectious diseases associated with molluscan shellfish consumption.
AU - Rippey, S. R.
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
Y1 - 1994///
VL - 7
IS - 4
SP - 419
EP - 425
SN - 0893-8512
AD - Rippey, S. R.: Northeast Seafood Laboratory, Food and Drug Administration, US Public Health Service, Davisville, RI 02852, USA.
N1 - Accession Number: 19952002390. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition; Public Health
N2 - A history of shellfish-vectored illnesses (i.e., those associated with consumption of clams, oysters, mussels, and scallops) occurring in the past nine decades is presented. Typhoid fever was a significant public health problem among consumers of raw molluscan shellfish earlier in this century. The development of more effective sewage treatment procedures and the institution of a national programme following these outbreaks led to a series of measures which eventually eliminated shellfish-associated typhoid fever. Present-day problems associated with this food source still involve some wastewater-borne bacterial illnesses. However, the principal public health concerns are with wastewater-derived viral pathogens and with bacterial agents of an environmental origin. The nature, occurrence of magnitude of these public health problems are described.
KW - food poisoning
KW - human diseases
KW - infectious diseases
KW - mussels
KW - oysters
KW - reviews
KW - shellfish
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - communicable diseases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002390&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concentrations and intakes of H, B, S, K, Na, Cl, and NaCl in foods.
AU - Anderson, D. L.
AU - Cunningham, W. C.
AU - Lindström, T. R.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1994///
VL - 7
IS - 1-2
SP - 59
EP - 82
SN - 0889-1575
AD - Anderson, D. L.: Elemental Research Branch (HFS-338), US Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19950402883. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7440-42-8, 7782-50-5, 1333-74-0, 7440-09-7, 7440-23-5, 7704-34-9. Subject Subsets: Human Nutrition; Dairy Science
N2 - Neutron capture prompt γ-ray activation analysis was used to determine H, B, Na, S, Cl, and K in 234 foods from the US FDA Total Diet Study collection K11 (Nov. 1990-Jan. 1991). Fruits, vegetables, and nuts had the highest B concentrations and supplied >50% of the dietary intake for B in 8 age/sex groups. Higher B concentrations in drinking water and greater fruit and vegetable intake could significantly increase B intakes. Added NaCl (i.e. introduced during processing or preparation) accounted for about 50% of the dietary Na and Cl for 6- to 11-month-old children and about75% of Na and 80% of Cl for all other age/sex groups. An estimated 10% of dietary Na was contributed by other additives, e.g. baking powder in grain products, emulsifying agents in processed cheese, and a variety of preservatives. S concentrations in food and S intakes were dominated by protein-related cysteine, with relatively little contribution from food additives. K and Na concentrations and intakes determined for collection K11 agreed very well with the 1982-89 Total Diet Study averages.
KW - boron
KW - cereal products
KW - cheeses
KW - children
KW - chlorine
KW - cows
KW - determination
KW - diet studies
KW - drinking water
KW - foods
KW - fruits
KW - hydrogen
KW - intake
KW - milk products
KW - minerals
KW - nuts
KW - potassium
KW - sodium
KW - sulfur
KW - vegetables
KW - USA
KW - cattle
KW - man
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - elemental sulphur
KW - sulphur
KW - United States of America
KW - vegetable crops
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Absence of evidence of retroviral infection in idiopathic CD4+ T-lymphocytopenia syndrome.
AU - Heredia, A.
AU - Muller, J.
AU - et al.
AU - Soriano, V. (
T2 - AIDS
JO - AIDS
JF - AIDS
Y1 - 1994///
VL - 8
IS - 2
SP - 267
EP - 268
SN - 0269-9370
AD - Heredia, A.: Laboratory of Molecular Virology, Division of Transfusion and Transmitted Diseases, Food and Drug Administration, Rockville Pike, MD 20852-1448, USA.
N1 - Accession Number: 19942006004. Publication Type: Correspondence. Language: English.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Aetiology
KW - Kaposi's sarcoma
KW - AIDS
KW - causal agents
KW - etiology
KW - idiopathic CD4 lymphocytopenia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006004&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Building an HIV care network in central Iowa.
AU - McKinney, M. M.
AU - Bragg, K.
JO - AIDS and Public Policy Journal
JF - AIDS and Public Policy Journal
Y1 - 1994///
VL - 9
IS - 3
SP - 114
EP - 122
SN - 0887-3852
AD - McKinney, M. M.: Chief of the Program Evaluation and Epidemiology Branch, Office of Science and Epidemiology, Bureau of Health Resources Development, Health Resources and Services Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19952003912. Publication Type: Journal Article. Language: English. Number of References: 6 ref.
KW - acquired immune deficiency syndrome
KW - community care
KW - funding
KW - HIV infections
KW - policy
KW - sociology
KW - Iowa
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - AIDS
KW - AIDS service organizations
KW - human immunodeficiency virus infections
KW - social aspects
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003912&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The organization and availability of HIV-related services in Baltimore, Maryland and Oakland, California.
AU - Macroni, K.
AU - Rundall, T.
AU - Gentry, D.
AU - Kwait, J.
AU - Celentano, D.
AU - Stolley, P.
JO - AIDS and Public Policy Journal
JF - AIDS and Public Policy Journal
Y1 - 1994///
VL - 9
IS - 4
SP - 173
EP - 181
SN - 0887-3852
AD - Macroni, K.: Science and Epidemiology, Bureau of Health Resources Development (BHRD), Health Resources and Services Administration (HRSA), U.S. Public Health Service, Rockville, Maryland, USA.
N1 - Accession Number: 19952006794. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
KW - acquired immune deficiency syndrome
KW - community care
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - public services
KW - California
KW - Maryland
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southern States of USA
KW - AIDS
KW - AIDS service organizations
KW - community services
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - medical care
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006794&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of respiratory protective devices in the control of tuberculosis.
AU - Hodous, T. K.
AU - Coffey, C. C.
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
Y1 - 1994///
VL - 9
IS - 4
SP - 631
EP - 657
SN - 0885-114X
AD - Hodous, T. K.: Division of Safety Research, National Institute for Occupational Safety and Health Morgantown, West Virginia, WV 26505, USA.
N1 - Accession Number: 19952005169. Publication Type: Journal Article. Language: English. Number of References: 83 ref. Subject Subsets: Public Health
N2 - The authors describe various types of respirators and the major issues in their application to tuberculosis control, including the degree of protection they offer and cost. Recent recommendations regarding the use of respiratory protective devices also are discussed.
KW - human diseases
KW - infection control
KW - mycobacterial diseases
KW - reviews
KW - tuberculosis
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - mycobacterial infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952005169&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control of Aedes albopictus larvae using time-release larvicide formulations in Louisiana.
AU - Basci, R. S.
AU - Wright, G. B.
AU - Willis, F. S.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1994///
VL - 10
IS - 1
SP - 1
EP - 6
SN - 8756-971X
AD - Basci, R. S.: Medical Entomology-Ecology Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19940501902. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 40596-69-8, 3383-96-8. Subject Subsets: Medical & Veterinary Entomology
N2 - The ability of time-release formulations of larvicides and insect growth regulators (IGRs) to provide long-term control of A. albopictus was investigated in the field. Larvicides used in the study were Bactimos pellets (Bacillus thuringiensis subsp. israelensis) and Abate pellets (temephos). The IGR Altosid (methoprene) was used in pellet and sand formulations. Application rates were higher than label recommendations. In a preliminary test, clay flower bowls were treated with 2 g of material. Bactimos pellets failed to provide control after 60 days. Abate pellets and the Altosid formulations provided essentially 100% control for 150 days. After 30 days in the field, the Abate pellets produced 100% larval mortality, and significant levels of control were provided by the Altosid formulations and the Bactimos pellets. In a small-scale operational trial of this technique, 1 g of Altosid pellets was applied to every container that could be located in 2 urban residential neighbourhoods in Lake Charles, Louisiana, USA. A. albopictus biting populations were monitored weekly in the treated areas and in an untreated control area. Biting population densities declined significantly in treated areas compared with the control area. Results suggested that long-term control of A. albopictus populations can be achieved economically with one application of Altosid pellets or Abate pellets in containers.
KW - aquatic animals
KW - aquatic insects
KW - bacterial insecticides
KW - biological control agents
KW - chemical control
KW - control
KW - controlled release
KW - insect control
KW - insect growth regulators
KW - insecticides
KW - introduced species
KW - larvae
KW - methoprene
KW - natural enemies
KW - pathogens
KW - pellets
KW - temephos
KW - urban areas
KW - water containers
KW - Louisiana
KW - USA
KW - Aedes albopictus
KW - Bacillus thuringiensis serovar. israelensis
KW - Culicidae
KW - Diptera
KW - insects
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - West South Central States of USA
KW - Bacillus thuringiensis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Asian tiger mosquito
KW - Bacillus thuringiensis subsp. israelensis
KW - bacterium
KW - biocontrol agents
KW - biological control organisms
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - slow release
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Biological Control (HH100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunopathogenic aspects of foodborne microbial disease.
AU - Bunning, V. K.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 1994///
VL - 11
IS - 2
SP - 89
EP - 95
SN - 0740-0020
AD - Bunning, V. K.: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Immunobiology Branch (HFS-326), 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19941301907. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 58 ref. Subject Subsets: Human Nutrition
N2 - Topics covered in this review article include: the development of chronic disease; the unique reasons for regulatory considerations to protect the immuno-suppressed from opportunist pathogens that contaminate food; the overlap of animal disease to food safety; and the importance of an understanding of molecular immunopathogenic mechanisms inherent to foodborne pathogens and their hosts.
KW - biodeterioration
KW - foodborne diseases
KW - immunopathology
KW - pathogens
KW - reviews
KW - immunopathogenesis
KW - Immunopathogenic aspects of foodborne microbial disease
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors controlling expression of virulence genes in Listeria monocytogenes.
AU - Datta, A. R.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 1994///
VL - 11
IS - 2
SP - 123
EP - 129
SN - 0740-0020
AD - Datta, A. R.: Division of Molecular Biological Research and Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington DC 20404, USA.
N1 - Accession Number: 19951302263. Publication Type: Journal Article. Language: English. Number of References: 35 ref.
N2 - Environmental factors that control the expression of virulence genes in Listeria monocytogenes and the effects of such factors on extracellular survival, growth and virulence properties are discussed.
KW - biodeterioration
KW - control
KW - gene expression
KW - genetics
KW - pathogens
KW - virulence
KW - bacteria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951302263&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transgenic fish: safe to eat? A look at the safety considerations regarding food transgenics.
AU - Berkowitz, D. B.
AU - Kryspin-Sørensen, I.
JO - Bio/Technology
JF - Bio/Technology
Y1 - 1994///
VL - 12
IS - 3
SP - 247
EP - 252
SN - 0733-222X
AD - Berkowitz, D. B.: Office of Small Business Scientific and Trade Affairs, U.S. Food and Drug Administration HF-50, Room 15-61, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19940103483. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Agricultural Biotechnology; Human Nutrition
N2 - This review discusses safety aspects of the insertion of foreign DNA into the genomes of fishes, the safety of transgenic fish as food, and possible unexpected consequences of gene transfer (pleiotropic effects). It is concluded that food safety evaluation of transgenic fishes has requirements similar to evaluations of the safety of added substances such as chemicals and drugs used orally or parenterally. Unanticipated effects of gene insertion are likely to be reflected in the health of the transgenic fishes.
KW - animal health
KW - biosafety
KW - biotechnology
KW - fish
KW - food safety
KW - foods
KW - gene transfer
KW - genetic engineering
KW - safety
KW - transgenics
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - genetic manipulation
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Aquaculture (Animals) (MM120)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940103483&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Murine T-helper cell immune response to recombinant vaccinia-Venezuelan equine encephalitis virus.
AU - Mathews, J. H.
AU - Kinney, R. M.
AU - Roehrig, J. T.
AU - Barrett, A. D. T.
AU - Trent, D. W.
JO - Vaccine
JF - Vaccine
Y1 - 1994///
VL - 12
IS - 7
SP - 620
EP - 624
SN - 0264-410X
AD - Mathews, J. H.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19942050667. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases
N2 - The T-helper (Th) cell immune response following immunization of C3H (H-2k) mice with a recombinant vaccinia (VAC) virus (TC-5A) expressing the structural proteins (capsid, E1 and E2) of the attentuated vaccine strain (TC-83) of Venezuelan equine encephalitis (VEE) virus was compared with the immune response induced in mice after immunization with TC-83 virus. TC-5A virus elicited Th cells that strongly recognized both VAC and TC-83 viruses in in vitro lymphoblastogenesis tests. Th-cell activation was associated with elevated levels of interleukin-2. TC-5A virus induced long-term humoral immunity; VEE virus-binding and neutralizing antibodies were detected in mouse sera collected from mice 16 months after a single immunization.
KW - immunization
KW - recombinant vaccines
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune sensitization
KW - Venezuelan equine encephalitis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050667&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protection of immunized and previously infected chimpanzees challenged with Mycoplasma pneumoniae.
AU - Barile, M. F.
AU - Grabowski, M. W.
AU - Kapatais-Zoumbois, K.
AU - Brown, B.
AU - Hu, P. C.
AU - Chandler, D. K. F.
JO - Vaccine
JF - Vaccine
Y1 - 1994///
VL - 12
IS - 8
SP - 707
EP - 714
SN - 0264-410X
AD - Barile, M. F.: Laboratory for Mycoplasma, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 19942050041. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Following immunization, peak geometric mean serum metabolism inhibition antibody (MIT) titres were 1:13 and 1:16 for groups of three chimpanzees each that received either the formalin-inactivated OSU-1A or experimental acellular extract vaccine, respectively. Following challenge, the mean titres for chimpanzees given the acellular vaccine peaked at 1:256 in 4 weeks and was 1:48 at 10 weeks. Chimpanzees given the OSU-1A vaccine peaked at 1:80 in 4 weeks and remained at 1:80 at 10 weeks. There was no direct correlation between the serum MIT response and the severity of disease or colonization, and thus the MIT response was not a reliable measurement of protection. The two non-immunized chimpanzees showed significant signs of disease, including cough, pharyngitis, rhinitis, fever and abnormal X-ray findings, for about 5 weeks. The chimpanzees immunized with either vaccine were less colonized and showed far less disease than non-immunized controls. Protection afforded the chimpanzees was similar to that of vaccinees in the human clinical trial given the same OSU-1A vaccine (Wenzel et al., Journal of Infectious Diseases, 1977, 136, S204). The two previously infected chimpanzees were most protected against colonization and disease on challenge.
KW - acellular vaccines
KW - immunization
KW - infections
KW - chimpanzees
KW - Mycoplasma pneumoniae
KW - Pan
KW - Pongidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycoplasma
KW - Mycoplasmataceae
KW - Mycoplasmatales
KW - Mollicutes
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - immune sensitization
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050041&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunogenicity of rabies vaccines used during an urban epizootic of rabies in Mexico.
AU - Eng, T. R.
AU - Fishbein, D. B.
AU - Talamante, H. E.
AU - Fekadu, M.
AU - Chavez, G. F.
AU - Muro, F. J.
AU - Baer, G. M.
JO - Vaccine
JF - Vaccine
Y1 - 1994///
VL - 12
IS - 14
SP - 1259
EP - 1264
SN - 0264-410X
AD - Eng, T. R.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19952003599. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Tropical Diseases
N2 - From 1 July 1987 to 31 December 1988, 30% of 247 rabid dogs in Hermosillo, Mexico had a positive history of rabies vaccination. Serosurveys suggested that inactivated suckling mouse brain vaccine (INACT-SMBV) and inactivated tissue culture vaccine (INACT-TC) used before and during the epizootic were poor immunogens. Prospective studies showed that only about one-third of dogs vaccinated with INACT-SMBV were seropositive 5 weeks after vaccination. Lack of vaccine potency was the most likely cause of poor immunogenicity. Rabies vaccines should be evaluated periodically by measuring antibody responses in animals. In some circumstances, minimum seroconversion rates and antibody titres in vaccinated animals may be better measures of immunogenicity than relative potency.
KW - epidemiology
KW - immune response
KW - immunization
KW - rabies
KW - vaccines
KW - Mexico
KW - North America
KW - dogs
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003599&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacteriophage-like particle of Rochalimaea henselae.
AU - Anderson, B.
AU - Goldsmith, C.
AU - Johnson, A.
AU - Padmalayam, M.
AU - Baumstark, B.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1994///
VL - 13
IS - 1
SP - 67
EP - 73
SN - 0950-382X
AD - Anderson, B.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950502101. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology
N2 - An extracellular particle ~40 nM in diameter was detected in culture supernatant from the fastidious bacterium R. henselae [Bartonella henselae]. This particle has at least 3 associated proteins and contains 14 kbp linear DNA segments that are heterogeneous in sequence. The 14 kbp DNA was also present in B. henselae cells as an extrachromosomal element for all 14 strains tested. Despite attempts to induce lysis of B. henselae, plaque formation was not observed. A similar particle, also containing 14 kbp DNA, was observed in B. bacilliformis and may be analogous to a bacteriophage that has been described elsewhere for B. bacilliformis.
KW - bacteriophages
KW - DNA
KW - molecular genetics
KW - virus-like particles
KW - Bartonella bacilliformis
KW - Bartonella henselae
KW - viruses
KW - Bartonella
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950502101&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cryptosporidiosis in child care settings: a review of the literature and recommendations for prevention and control.
AU - Cordell, R. L.
AU - Addiss, D. G.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 1994///
VL - 13
IS - 4
SP - 310
EP - 317
SN - 0891-3668
AD - Cordell, R. L.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19950802474. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Protozoology; Public Health
N2 - Cryptosporidium is a common cause of diarrhoea in young children attending day care centres. The literature is reviewed with reference to outbreaks, occurrence in non-outbreak settings, asymptomatic excretion, oocyst survival and disinfection, and prevention and control. It is concluded that more research is needed on epidemiology, diagnosis and the development of control strategies.
KW - child care
KW - children
KW - control
KW - cryptosporidiosis
KW - day care centres
KW - diarrhoea
KW - human diseases
KW - parasites
KW - reviews
KW - North America
KW - USA
KW - Apicomplexa
KW - Cryptosporidiidae
KW - Cryptosporidium
KW - man
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Eucoccidiorida
KW - Apicomplexa
KW - Cryptosporidiidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - day care centers
KW - day centres
KW - diarrhea
KW - scouring
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950802474&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbial survey of shared-use cosmetic test kits available to the public.
AU - Tran, T. T.
AU - Hitchins, A. D.
JO - Journal of Industrial Microbiology
JF - Journal of Industrial Microbiology
Y1 - 1994///
VL - 13
IS - 6
SP - 389
EP - 391
SN - 0169-4146
AD - Tran, T. T.: Division of Microbiological Studies, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951302335. Publication Type: Journal Article. Language: English. Number of References: 8 ref.
N2 - Some people like to try cosmetics before purchasing them. With repeated use by different customers, however, the tester kits provided by many retail outlets can become potential vectors of microbial pathogens. A survey was conducted to assess the health risk from bacteria found on shared-use cosmetics. A total of 3027 shared-use cosmetic product samples were collected from 171 retail establishments throughout the contiguous United States. Eye, face and lip cosmetics were tested with in situ nondestructive swabbing and the use of the Transette 3R Modified Amies Charcoal Culture and Transport System. Bacteria were isolated from about 50% of the items for all three categories. Semiquantitatively-estimated mean densities were 2288, 1685 and 1088 c.f.u./g for eye, face and lip products, resp. Ranges for all categories were 0-105 c.f.u./g. About 5% of the items had bacterial counts above 5000 c.f.u./g (eye products) or 10 000 c.f.u./g (other products). More than 60% of isolates were typical of microflora from human skin; the remainder were environmental microbes. About 60% of the isolates were Gram-positive cocci: Staphylococcus spp. (especially S. epidermidis) and Micrococcus spp. The Gram-negative pathogen Pseudomonas aeruginosa constituted 0.07% of the isolates. The survey results suggest that the preservation systems of some of the cosmetics failed under excessive use (abuse), and indicated a potential for microbiological safety problems with shared-use cosmetics.
KW - biodeterioration
KW - contamination
KW - cosmetics
KW - pathogens
KW - Pseudomonas aeruginosa
KW - Staphylococcus epidermidis
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - bacterium
KW - Micrococcus
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Biodeterioration (Non-biological Products) (SS310) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951302335&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical trials: the utility of large, simple trials in the evaluation of AIDS treatment strategies.
AU - Ellenberg, S. S.
AU - Foulkes, M. A.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 1994///
VL - 13
IS - 5,6,7
SP - 405
EP - 415
SN - 0277-6715
AD - Ellenberg, S. S.: Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19942026603. Publication Type: Journal Article. Language: English. Number of References: 38 ref.
KW - ACQUIRED IMMUNE DEFICIENCY SYNDROME
KW - Clinical trials
KW - Design
KW - HIV infections
KW - mathematical models
KW - Methodology
KW - Statistics
KW - Treatment
KW - AIDS
KW - human immunodeficiency virus infections
KW - methods
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942026603&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Indoor air quality and non-IgE-mediated immunologic respiratory disease.
AU - Parker, J. E.
AU - Siegel, P. D.
AU - Lewis, D. M.
A2 - Banks, D. E.
A2 - Weissman, D. N.
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
Y1 - 1994///
VL - 14
IS - 3
SP - 591
EP - 605
SN - 0889-8561
AD - Parker, J. E.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 19951200067. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 84 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The clinical presentation, diagnosis and laboratory studies of humidifier fever and hypersensitivity pneumonitis are reviewed. The clinical picture, radiographic abnormalities, diagnostic criteria, pathology, bronchoalveolar lavage cells and cytokines, fibrosis and experimental hypersensitivity pneumonitis are also discussed. The similarities and differences between humidifier fever and hypersensitivity pneumonitis are considered.
KW - allergies
KW - humidifier disease
KW - reviews
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - hypersensitivity pneumonitis
KW - Indoor air pollution - an allergy perspective
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Weeds and Noxious Plants (FF500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200067&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concerns regarding the occurrence of Listeria monocytogenes, Campylobacter jejuni, and Escherichia coli 0157:H7 in foods regulated by the U.S. Food and Drug Administration.
AU - Madden, J. M.
JO - Dairy, Food and Environmental Sanitation
JF - Dairy, Food and Environmental Sanitation
Y1 - 1994///
VL - 14
IS - 5
SP - 262
EP - 267
SN - 1043-3546
AD - Madden, J. M.: Microbiology Cenrer for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951302246. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Human Nutrition
N2 - The incidence and distribution in the USA of the foodborne pathogens Listeria monocytogenes, Campylobacter jejuni and Escherichia coli 0157:H7 are examined. Foodborne outbreaks caused by these pathogens are described. Sources and occurrences of the pathogens are discussed. Measures for controlling these pathogens in the food chain are outlined. The role of the Food and Drug Administration in the surveillance and control of these pathogens is discussed.
KW - biodeterioration
KW - control
KW - foodborne diseases
KW - foods
KW - monitoring
KW - pathogens
KW - USA
KW - bacteria
KW - Campylobacter jejuni
KW - Escherichia coli
KW - Listeria monocytogenes
KW - prokaryotes
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - surveillance systems
KW - United States of America
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951302246&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Caloric restriction profoundly inhibits liver tumor formation after initiation by 6-nitrochrysene in male mice.
AU - Fu, P. P.
AU - Dooley, K. L.
AU - Tungeln, L. S. von
AU - Bucci, T.
AU - Hart, R. W.
AU - Kadlubar, F. F.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1994///
VL - 15
IS - 2
SP - 159
EP - 161
SN - 0143-3334
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19951412014. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - Energy restriction (ER) inhibited strongly the incidence of chemically-induced tumours in the neonatal B6C3F1 mouse tumourigenicity bioassay, when begun 3 months after treatment with the potent carcinogen 6-nitrochrysene. The data indicate that CR can have a profound inhibitory effect on tumour development even long after metabolic activation and DNA repair have occurred.
KW - carcinogenesis
KW - energy deprivation
KW - inhibition
KW - liver
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951412014&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Creating an agenda for research and evaluation: HIV service delivery, the Ryan White CARE Act, and beyond.
AU - Weissman G.
AU - McClain, M.
AU - Hines, R.
AU - Harder, P.
AU - Gross, M.
AU - Marconi, K. M.
AU - Bowen, G. S.
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 1994///
VL - 15
IS - 3
SP - 329
EP - 344
SN - 0197-5897
AD - Weissman G.: Office of Science and Epidemiology, Bureau of Health Resources Development, Health Resources and Services Administration, Department of Health and Human Services, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19952001528. Publication Type: Journal Article. Language: English.
KW - acquired immune deficiency syndrome
KW - evaluation
KW - health services
KW - HIV infections
KW - policy
KW - research
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus infections
KW - studies
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001528&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Fatal gastroenteritis due to Vibrio fluvialis and nonfatal bacteremia due to Vibrio mimicus: unusual Vibrio infections in two patients.
AU - Klontz, K. C.
AU - Cover, D. E.
AU - Hyman, F. N.
AU - Mullen, R. C.
T2 - Clinical Infectious Diseases
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1994///
VL - 19
IS - 3
SP - 541
EP - 542
SN - 1058-4838
AD - Klontz, K. C.: Epidemiology Branch, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19952008863. Publication Type: Correspondence. Language: English. Number of References: 5 ref.
N2 - Cases in a 54-year-old man from Michigan and a 74-year-old man from Florida, USA, are reported.
KW - gastroenteritis
KW - human diseases
KW - infections
KW - Florida
KW - Michigan
KW - North America
KW - USA
KW - man
KW - Vibrio fluvialis
KW - Vibrio mimicus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - East North Central States of USA
KW - North Central States of USA
KW - Lake States of USA
KW - bacterium
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008863&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - On the development of antifungal agents: perspective of the U.S. Food and Drug Administration.
AU - Wu, T. C.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1994///
VL - 19
IS - Suppl. 1
SP - S54
EP - S58
SN - 1058-4838
AD - Wu, T. C.: Division of Antiviral Drug Products, US Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19951201528. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The regulatory process of drug approval in the USA is briefly reviewed and issues specific to the design of clinical trials for the treatment of systemic fungal diseases are discussed, such as choice of controls, equivalence trials, number of studies and outcome measures.
KW - antifungal agents
KW - drug therapy
KW - mycoses
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - Focus on fungal infections 3
KW - fungistats
KW - rules
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951201528&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Standardizing a sensitive method for detection of the AIDS virus.
AU - Bockstahler, L. E.
JO - ASTM Standardization News
JF - ASTM Standardization News
Y1 - 1994///
VL - 22
IS - 3
SP - 50
EP - 53
SN - 0090-1210
AD - Bockstahler, L. E.: Molecular Biology Branch, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19952004490. Publication Type: Journal Article. Language: English. Number of References: 3 ref.
KW - acquired immune deficiency syndrome
KW - clinical aspects
KW - diagnosis
KW - HIV infections
KW - human diseases
KW - polymerase chain reaction
KW - standards
KW - AIDS
KW - clinical picture
KW - human immunodeficiency virus infections
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004490&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Susceptibility of the Sf9 insect cell line to infection with adventitious viruses.
AU - Zhang, P. F.
AU - Klutch, M.
AU - Muller, J.
AU - Marcus-Sekura, C. J.
JO - Biologicals
JF - Biologicals
Y1 - 1994///
VL - 22
IS - 3
SP - 205
EP - 213
SN - 1045-1056
AD - Zhang, P. F.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19950508121. Publication Type: Journal Article. Language: English. Number of References: 16 ref.
N2 - Sf9, the insect (Spodoptera frugiperda) cell line commonly used for gene expression by recombinant baculovirus (BV), can be infected by St. Louis encephalitis (SLE) virus, a flavivirus, resulting in a persistent, productive and cytopathic infection, while retaining the ability to be infected with a recombinant baculovirus (rBV). It is now demonstrated using double immunofluorescence that single cells are dually infected with SLE virus and rBV. 14 additional viruses including additional flaviviruses, other arbovirus classes, vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1) failed to produce a cytopathic effect (CPE) in Sf9 cells. Plaque assays indicated that infectious virus was present for several weeks post-inoculation for yellow fever (YF), dengue types 1 and 2 (DEN-1 and DEN-2), Gumbo limbo (GL), eastern equine encephalomyelitis virus (EEE), western equine encephalomyelitis virus (WEE), HSV-1 and VSV viruses. For HSV-1, GL, EEE, WEE and VSV, but not for YF, DEN-1 or DEN-2 viruses, this could be attributed solely to survival in the Sf9 cell culture media. Of the 14 viruses tested, only HSV- 1 could be detected after 2 weeks in serum-free media. The data indicate that several viruses which are pathogenic for humans are stable for long periods of time at 27°C in the serum-containing media used for cultivation of Sf9 cells. YF, DEN-1 and DEN-2 viruses may replicate in Sf9 cells at extremely low levels. This suggests that adventitious agents which do not produce obvious CPE or interfere with rBV infection or recombinant protein expression could contaminate Sf9 cell cultures or media.
KW - arboviruses
KW - cell culture
KW - cell lines
KW - cytopathogenicity
KW - herpes simplex viruses
KW - human herpesviruses
KW - infection
KW - recombinant proteins
KW - vesicular stomatitis viruses
KW - baculovirus
KW - dengue virus
KW - eastern equine encephalitis virus
KW - Spodoptera frugiperda
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - western equine encephalitis virus
KW - yellow fever virus
KW - Baculoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - Spodoptera
KW - Noctuidae
KW - Lepidoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Vesiculovirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - Herpesviridae
KW - arthropod-borne viruses
KW - Gumbo limbo virus
KW - herpes simplex virus
KW - Human herpesvirus
KW - vesicular stomatitis virus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950508121&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of needlestick injuries to health care workers providing home care.
AU - Backinger, C. L.
AU - Koustenis, G. H.
JO - American Journal of Infection Control
JF - American Journal of Infection Control
Y1 - 1994///
VL - 22
IS - 5
SP - 300
EP - 306
SN - 0196-6553
AD - Backinger, C. L.: Division of Professional Practices, Office of Training and Assistance, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19952008546. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - In June and July 1992, a random sample of 600 directors of home health care agencies in the USA were sent questionnaires concerning written blood-borne infection control policies and procedures of home health care agencies. Agency characteristics were also identified. A 46% response rate (n = 278) was obtained. Of the 226 agencies that reported needlestick injury rates, 102 agencies reported no needlestick injuries to home health care agency employees in the "last year" and 124 agencies reported from 1 to 134 needlestick injuries, for a cumulative total of 475. Statistical analyses revealed that agencies with "safer" sharps containers, "safer" hypodermics, or "safer" access to intravenous administration lines did not have statistically significant rates of lower needlestick injury than agencies without these "safer" products. This study should be considered exploratory; causal relationships cannot be established. Although written blood-borne infection control policies and procedures do not appear to provide protection to home health care workers from the risk of needlestick injury, limitations in the data exist.
KW - health care workers
KW - human diseases
KW - needlestick injuries
KW - occupational hazards
KW - occupations
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008546&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An overview of parasitic diseases in children in the United States: what's old? what's new? where's help?
AU - Richards, F. O.
JO - Pediatric Annals
JF - Pediatric Annals
Y1 - 1994///
VL - 23
IS - 8
SP - 392
EP - 397
SN - 0090-4481
AD - Richards, F. O.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Serbvice, US Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19950809241. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Helminthology; Protozoology
N2 - This general review of parasitic diseases in children in the USA examines traditional concepts of paediatric care and compares them with the present situation in which a number of parasitic infections have increased in frequency and importance over the past 2 decades, including cryptosporidiosis and babesiosis. The review examines treatment, both traditional and recent, and discusses briefly the problem of drug resistance in malaria and drugs for other protozoal and helminth infections. The services provided by the Centers for Disease Control and Prevention (CDC) are described and a number of telephone numbers are given to enable practitioners and patients to receive advice from the CDC on aspects of international travel, treatment and immunodiagnosis.
KW - babesiosis
KW - children
KW - cryptosporidiosis
KW - diagnosis
KW - drug resistance
KW - drug therapy
KW - epidemiology
KW - health care
KW - helminthoses
KW - helminths
KW - human diseases
KW - immunodiagnosis
KW - parasites
KW - parasitoses
KW - protozoal infections
KW - public health
KW - reviews
KW - travel
KW - treatment
KW - USA
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - protozoal diseases
KW - red water
KW - serological diagnosis
KW - tick fever
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of porphyria cutanea tarda in U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
AU - Calvert, G. M.
AU - Sweeney, M. H.
AU - Fingerhut, M. A.
AU - Hornung, R. W.
AU - Halperin, W. E.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1994///
VL - 25
IS - 4
SP - 559
EP - 571
SN - 0271-3586
AD - Calvert, G. M.: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19942310145. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Weeds
N2 - A cross-sectional medical study was performed to evaluate whether occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCCD)-contaminated substances is associated with porphyria cutanea tarda or porphyrinuria. The exposed participants were employed more than 15 years earlier in the manufacture of sodium trichlorophenol and its derivatives in 1 of 2 plants located in Newark, New Jersey and Verona, Missouri. The referent group consisted of individuals with no occupational exposure to phenoxy herbicides. A total of 281 workers and 260 controls were examined. Workers were found to have a statistically significantly elevated mean serum TCDD level (220 and 7 pg/g of lipid for workers and controls, resp.). There were no other statistically significant differences between workers and controls for any other demographic characteristics. The pattern of urinary porphyrin excretion for each participant was assessed to determine if symptomatic or subclinical porphyria cutanea tarda was present. None of the participants were found to have symptomatic porphyria cutanea tarda. No difference was found between workers and controls in the prevalence of subclinical porphyria cutanea tarda (odds ratio [OR]=0.93, 95% confidence interval [CI] 0.19, 4.54). There were also no differences in the risk between workers and controls for an out-of-range urinary uroporphyrin or coproporphyrin concn. It was concluded that this study did not find an elevated risk for porphyria cutanea tarda or porphyrinuria among workers with high serum TCDD levels.
KW - herbicides
KW - occupational disorders
KW - phenoxy herbicides
KW - porphyria
KW - toxicology
KW - Missouri
KW - New Jersey
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942310145&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The enterics as foodborne pathogens.
AU - Madden, J. M.
JO - Food Research International
JF - Food Research International
Y1 - 1994///
VL - 27
IS - 3
SP - 227
EP - 232
SN - 0963-9969
AD - Madden, J. M.: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, District of Columbia 20204, USA.
N1 - Accession Number: 19951300812. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - The pathogenicity of enteric bacteria such as Vibrio cholerae and Salmonella typhi is undisputed and has been widely recognized by microbiologists and the public in general for many years. However, very little is known about the mechanisms that attribute the characteristics of virulence to these microbes, except perhaps for cholera toxin, which is required for V. cholerae to produce Asiatic (Epidemic) cholera. Cholera and typhoid fever basically have been controlled in Europe and North America by proper water and sewage treatment, leaving a niche to be filled by other bacteria. These microbes, the so-called 'emerging pathogens', which include members of the genera Vibrio, Salmonella, and other-enteric bacteria, account for the vast majority of gastroenteritis cases reported in Europe and North America. Their emergence as pathogens may be due to their mutation, which enables them to co-exist with certain animals (S. enteritidis may fall into this category), or to the transfer of plasmids bearing virulence determinants between various enteric genera.
KW - biodeterioration
KW - foodborne diseases
KW - pathogens
KW - reviews
KW - enterobacteriaceae
KW - Salmonella enteritidis
KW - Salmonella typhi
KW - Vibrio cholerae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - bacterium
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of Fumonitest immunoaffinity columns.
AU - Ware, G. M.
AU - Umrigar, P. P.
AU - Carman, A. S., Jr.
AU - Kuan, S. S.
JO - Analytical Letters
JF - Analytical Letters
Y1 - 1994///
VL - 27
IS - 4
SP - 693
EP - 715
SN - 0003-2719
AD - Ware, G. M.: Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122, USA.
N1 - Accession Number: 19941200979. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Maize; Postharvest Research
N2 - A method for the determination of fumonisins B1 and B2 in maize was developed, involving sample extraction with methanol:water (80:20) and the use of a commercially available Fumonitest column for sample clean-up. The capacity, selectivity, column-to-column and lot-to-lot reproducibility of the Fumonitest columns were evaluated. The total capacity of the column was 1.2 µg fumonisin. Fumonisins B1 and B2 had an equal affinity toward the Fumonitest column, with the sample matrix demonstrating little effect on the column performance. The max. sample size was 0.5 g for samples containing total fumonisins of <2 p.p.m. After elution from the immunoaffinity column, fumonisins B1 and B2 were reacted with naphthalene-2,3-dicarboxaldehyde to produce a highly fluorescent derivative, 1-cyano-2-alkyl-benz[f]isoindole. The derivatives were then separated from the sample matrix on a reverse phase C-18 column with a mobile phase consisting of acetonitrile:water:acetic acid (55:45:1). Mean recoveries of fumonisins B1 and B2 from maize samples spiked at a level of 1000 ng (500ng B1 + 500ng B2)/g were 85.4 and 87.1%, respectively. The detection limit for B1 and B2 was estimated to be 10 and 4 p.p.b., respectively. The coefficients of variation for fumonisins B1 and B2 were 10.2 and 10.6%, respectively.
KW - analytical methods
KW - contamination
KW - determination
KW - estimation
KW - fumonisins
KW - maize
KW - mycotoxins
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - corn
KW - fungal toxins
KW - immunoaffinity chromatography
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - White-tailed deer as a potential reservoir of Ehrlichia spp.
AU - Dawson, J. E.
AU - Childs, J. E.
AU - Biggie, K. L.
AU - Moore, C.
AU - Stallknecht, D.
AU - Shaddock, J.
AU - Bouseman, J.
AU - Hofmeister, E.
AU - Olson, J. G.
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
Y1 - 1994///
VL - 30
IS - 2
SP - 162
EP - 168
SN - 0090-3558
AD - Dawson, J. E.: Viral and Rickettsial Zoonoses Branch, Public Health Service, U. S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942216100. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - The antibody prevalence to Ehrlichia spp., in white-tailed deer (Odocoileusvirginianus) and the geographic distribution of seropositive animals in 84 counties in Alamaba, Arkansas, Florida, Georgia, Illinois, Kentucky, Louisiana, Maryland, Massachusetts, Mississippi, Missouri, North Carolina, South Carolina, Tennessee, Texas, Virginia, and West Virginia (USA) were investigated. Using an indirect fluorescent antibody test antibodies (≥1:128) to Ehrlichia chaffeensis or closely related species were detected in 544 (43%) of 1269 deer. Presence of antibodies to Ehrlichia spp. was related to a southerly latitude, low elevation, and resulting milder climatic conditions. It appears that white tailed deer were naturally infected with Ehrlichia spp.; the infection was widely distributed throughout the southeastern USA. Based on these results it is suggested that white-tailed deer play a role in the natural history of Ehrlichia spp. infection in the USA. The possible role of Amblyomma americanum in the epidemiology is discussed.
KW - bacterial diseases
KW - disease surveys
KW - disease vectors
KW - epidemiology
KW - serological surveys
KW - wild animals
KW - USA
KW - Acari
KW - Amblyomma americanum
KW - Arachnida
KW - Cervidae
KW - Ehrlichia
KW - Ehrlichia chaffeensis
KW - Ixodidae
KW - Odocoileus
KW - Odocoileus virginianus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Amblyomma
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ehrlichia
KW - Cervidae
KW - Odocoileus
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - disease surveillance
KW - lone star tick
KW - seroepidemiology
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measurement of flight tone differences between female Aedes aegypti and A. albopictus (Diptera: Culicidae).
AU - Brogdon, W. G.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1994///
VL - 31
IS - 5
SP - 700
EP - 703
SN - 0022-2585
AD - Brogdon, W. G.: Entomology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950500084. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Mosquito flight tone was amplified and digitally sampled at 20 000 samples per second (Hz). Resampling of the resulting sound files at 1000, 5000 and 10 000 Hz allowed comparison of flight tone frequency distributions for males and females of A. aegypti and A. albopictus. Frequency distributions for females of the 2 species did not overlap at sampling rates of 5000 Hz or higher, whereas considerable overlap was observed at the 1000 Hz sampling rate. Males of the 2 species produced flight tones higher in frequency than those of females, but similar to each other. At the highest sampling rate, 7 flight harmonics were measured for each species. Close correspondence of the means of the flight tone harmonics (corrected for harmonic number) demonstrated that any of the harmonics may be used accurately and precisely to calculate flight tone frequency. These data indicate that flight tone differences have been selected in these species and could act as an isolating mechanism for mating.
KW - behaviour
KW - flight
KW - mating behaviour
KW - physiology
KW - sounds
KW - Aedes
KW - Aedes aegypti
KW - Aedes albopictus
KW - Culicidae
KW - Diptera
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Asian tiger mosquito
KW - behavior
KW - mating behavior
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Carotene inhibition of chemically induced toxicity in vivo and in vitro.
AU - Kornhauser, A.
AU - Wamer, W. G.
AU - Lambert, L. A.
AU - Wei, R. R.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1994///
VL - 32
IS - 2
SP - 149
EP - 154
SN - 0278-6915
AD - Kornhauser, A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941412504. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
N2 - The role of β-carotene in modifying 2-stage skin tumourigenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by phorbol 12-myristate 13-acetate (PMA, TPA) was examined. 2 types of dietary β-carotene, a beadlet formulation and crystalline β-carotene, were compared in 2 strains of mice (Skh:HR-1 and CR:ORL Sencar). Mice were maintained on food fortified with 3% β-carotene or on control diets. Mice receiving the β-carotene-supplemented diets had fewer tumours than mice in the control groups. However, only in the Skh strain was this difference significant. In a second study, an in vitro experiment, BALBc 3T3 mouse fibroblasts were used to estimate β-carotene's accumulation in cells and the ability of these cells to metabolize β-carotene to vitamin A. This in vitro model was also used to show a β-carotene protective effect towards phototoxicity. The studies contribute to the increasing evidence of in vivo and in vitro protection by β-carotene against chemically induced toxicity.
KW - beta-carotene
KW - carcinogenesis
KW - in vitro
KW - inhibition
KW - intake
KW - toxicity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412504&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An integrated target sequence and signal amplification assay, reverse transcriptase-PCR-enzyme-linked immunosorbent assay, to detect and characterize flaviviruses.
AU - Chang GwongJen
AU - Trent, D. W.
AU - Vorndam, A. V.
AU - Vergne, E.
AU - Kinney, R. M.
AU - Mitchell, C. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1994///
VL - 32
IS - 2
SP - 477
EP - 483
SN - 0095-1137
AD - Chang GwongJen: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19940500883. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2 - A reverse transcriptase-polymerase chain reaction using flavivirus genus-conserved and virus species-specific amplimers was previously described [see D.W. Trent & G.J. Chang (1992), pp. 355-371, in Y. Becker & C. Darai (Eds.) Frontiers of Virology, Vol. 1]. Target amplification was improved by redesigning the amplimers, and a sensitive ELISA technique has been developed to detect amplified digoxigenin (DIG)-modified DNA. A single biotin motif and multiple DIG motifs were incorporated into each amplicon, which permitted amplicon capture by a biotin-streptavidin interaction and detection with DIG-specific antiserum in a colorimetric ELISA. The utility of this assay for detecting St. Louis encephalitis (SLE) viral RNA in infected mosquitoes (Culex pipiens) and dengue viral RNA in human serum specimens was evaluated. The reverse transcriptase-PCR-ELISA was as sensitive as isolation of SLE virus by cell culture in detecting SLE viral RNA in infected mosquitoes. The test was 89% specific and 95-100% sensitive for identification of dengue viral RNA in serum specimens compared with isolation of virus by Aedes albopictus C6/36 cell culture and identification by the indirect immunofluorescence assay.
KW - arboviruses
KW - biotechnology
KW - cell lines
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - disease vectors
KW - ELISA
KW - immunodiagnosis
KW - polymerase chain reaction
KW - RNA
KW - Aedes albopictus
KW - Culex pipiens
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - Flavivirus
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culex
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - enzyme linked immunosorbent assay
KW - mosquitoes
KW - PCR
KW - ribonucleic acid
KW - serological diagnosis
KW - Aquatic Biology and Ecology (MM300)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Supercritical fluid chromatography of garlic (Allium sativum) extracts with mass spectrometric identification of allicin.
AU - Calvey, E. M.
AU - Roach, J. A. G.
AU - Block, E.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 1994///
VL - 32
IS - 3
SP - 93
EP - 96
SN - 0021-9665
AD - Calvey, E. M.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19940306345. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Horticultural Science; Human Nutrition
N2 - Supercritical fluid chromatography-mass spectrometry was used successfully to identify allicin (2-propene-1-sulphinothioic acid S-2-propenyl ester), the predominant thiosulphinate in freshly cut garlic. A low oven temperature (50°C) and low restrictor tip temperature (115°) were needed in order to obtain a chemical ionization (CI) mass spectrum of allicin with the protonated molecular ion, m/z 163, as the major ion. The effects of tip temperature on the CI mass spectrum of allicin are presented.
KW - analytical methods
KW - bulbs
KW - chromatography
KW - composition
KW - determination
KW - flavour compounds
KW - garlic
KW - vegetables
KW - volatile compounds
KW - Alliaceae
KW - Allium sativum
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Allium
KW - Alliaceae
KW - Liliaceae
KW - analytical techniques
KW - flavor compounds
KW - thiosulfinates
KW - vegetable crops
KW - volatile constituents
KW - Techniques and Methodology (ZZ900)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940306345&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of ethanol and vitamin A excess on vitamin A status in the liver, plasma and foetuses of pregnant rats.
AU - Sundaresan, P. R.
AU - Collins, T. F. X.
AU - Whitby, K. E.
AU - Welsh, J. J.
AU - Black, T. N.
AU - Shackelford, M.
AU - Flynn, T.
AU - Newell, R. F.
AU - O'Donnell, M. W.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1994///
VL - 32
IS - 3
SP - 247
EP - 254
SN - 0278-6915
AD - Sundaresan, P. R.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19941412509. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 64-17-5, 68-26-8. Subject Subsets: Human Nutrition
N2 - The effect of maternal consumption of dietary ethanol and high doses of vitamin A by gavage was investigated by evaluating plasma, liver and foetal vitamin A in Osborne-Mendel pregnant rats with a view to assessing whether ethanol modulated the potential toxicity of excess vitamin A. All groups received vitamin A 4000 IU/litre in a liquid diet. Ethanol-exposed groups also received 6.4% (v/v) ethanol in the liquid diet. Vitamin A was administered by gavage once per day in maize oil in doses ranging from 10 000 to 160 000 IU/kg body weight. Plasma vitamin A concentrations in ethanol-exposed groups were similar to those in a pair-fed group. Plasma vitamin A concentrations were similar in the group given ethanol plus vitamin A 40 000 IU/kg and the group given 40 000 IU/kg only, but were higher in the group receiving ethanol plus 80 000 IU/kg than in the group given 80 000 IU/kg only. Retinyl esters were present in the plasma of rats receiving 160 000 IU/kg only, indicating possible saturation of the liver with vitamin A. Retinyl palmitate concentrations in female foetuses of the group administered ethanol plus vitamin A 80 000 IU/kg were significantly higher than those of the group administered 80 000 IU/kg only; no significant differences in concentrations of retinyl palmitate in male foetuses were observed between these 2 groups. This observation suggests a possible sex difference in the modulation of vitamin A toxicity by ethanol in the foetus.
KW - blood
KW - ethanol
KW - fetus
KW - intake
KW - liver
KW - pregnancy
KW - retinol
KW - vitamin A excess
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - ethyl alcohol
KW - foetus
KW - gestation
KW - hypervitaminosis A
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A toxicity
KW - vitamin A1
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412509&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mineral interactions in rats fed AIN-76A diets with excess calcium.
AU - Shackelford, M. E.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Ames, M. J.
AU - Dolan, S.
AU - Sheikh, N. S.
AU - Chi, R. K.
AU - O'Donnell, M. W.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1994///
VL - 32
IS - 3
SP - 255
EP - 263
SN - 0278-6915
AD - Shackelford, M. E.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941412510. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7440-70-2, 7439-89-6, 7439-95-4, 7723-14-0, 7440-66-6. Subject Subsets: Human Nutrition
N2 - The effects of moderate increases in dietary calcium on maternal and foetal mineral interactions were studied in Charles River CD/VAF Plus rats. Female rats were given Ca 0.50, 0.75, 1.00 or 1.25% as calcium carbonate in AIN-76A diets for 6 weeks before mating, during mating and for 20 days of gestation. Inductively coupled argon plasma-atomic emission spectrometry was used to estimate mineral concentrations in the tissues of non-pregnant rats after 42 days on the diets, in the tissues of pregnant rats on day 20 of gestation and in the whole body of day-20 foetuses. The femurs of the non-pregnant and pregnant rats had a dose-related linear increase in Ca content. In livers of non-pregnant rats, dose-related linear increases in the phosphorus, zinc and magnesium content were observed, but there was a dose-related decrease in the iron content. There were dose-related linear decreases in the iron and copper contents of the kidneys from the non-pregnant rats. In pregnant rats, dose-related linear decreases were observed in the iron content of the liver and in the zinc, iron and magnesium contents of the kidney. The foetuses from rats given a moderate increase in dietary Ca had dose-related decreases in the whole-body contents of phosphorus, iron, copper and magnesium.
KW - calcium
KW - intake
KW - iron
KW - magnesium
KW - mineral metabolism
KW - phosphorus
KW - zinc
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412510&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Bordetella pertussis infection by shared-primer PCR.
AU - Li, Z.
AU - Jansen, D. L.
AU - Finn, T. M.
AU - Halperin, S. A.
AU - Kasina, A.
AU - O'Connor, S. P.
AU - Aoyama, T.
AU - Manclark, C. R.
AU - Brennan, M. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1994///
VL - 32
IS - 3
SP - 783
EP - 789
SN - 0095-1137
AD - Li, Z.: Division of Bacterial Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 20892, USA.
N1 - Accession Number: 19952002135. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - A shared-primer PCR method for the detection of infection was developed by using primers derived from DNA sequences upstream of the structural genes for the porin proteins of Bordetella pertussis and B. parapertussis. This method resulted in a 159-bp PCR product specific for B. pertussis and a 121-bp DNA fragment specific for B. parapertussis and allowed for the simultaneous detection of these pathogens. The PCR procedure was shown to be very specific since no PCR product was obtained from 36 non-Bordetella bacterial DNAs. Nasopharyngeal aspirates (NPAs) from children suspected of having pertussis were evaluated by the PCR method, culture, and the Chinese hamster ovary (CHO) cell assay, which detects pertussis toxin. B. pertussis was cultured from 119 of 205 NPAs assayed, and the presence of pertussis toxin was detected in 69 of the NPAs by the CHO cell assay. When ethidium bromide staining was used to detect PCR products, 100 NPAs gave positive results by shared-primer PCR; 94 of these NPAs were also positive by culture. The result indicated a sensitivity of 79% for PCR when culture was used as the standard. The sensitivity of PCR was increased to 95% when a digoxigenin immunoblot system was used. An additional 20 NPAs from patients with suspected pertussis that were culture negative also gave positive results by PCR. The specific and sensitive PCR method described here should be useful for both the clinical diagnosis of pertussis and case identification in vaccine trials.
KW - human diseases
KW - identification
KW - infections
KW - polymerase chain reaction
KW - North America
KW - USA
KW - Bordetella
KW - Bordetella parapertussis
KW - Bordetella pertussis
KW - man
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bordetella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - PCR
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952002135&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developmental effects of combined exposure to ethanol and vitamin A.
AU - Whitby, K. E.
AU - Collins, T. F. X.
AU - Welsh, J. J.
AU - Black, T. N.
AU - Flynn, T.
AU - Shackelford, M.
AU - Ware, S. E.
AU - O'Donnell, M. W.
AU - Sundaresan, P. R.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1994///
VL - 32
IS - 4
SP - 305
EP - 320
SN - 0278-6915
AD - Whitby, K. E.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19941412453. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 64-17-5, 68-26-8. Subject Subsets: Human Nutrition
KW - development
KW - ethanol
KW - pregnancy
KW - retinol
KW - toxicity
KW - young animals
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - ethyl alcohol
KW - gestation
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941412453&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infections with intestinal parasites in Peace Corps volunteers in Guatemala.
AU - Herwaldt, B. L.
AU - Arroyave, K. R. De
AU - Wahlquist, S. P.
AU - Pée, L. J. Du
AU - Eng, T. R.
AU - Juranek, D. D.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1994///
VL - 32
IS - 5
SP - 1376
EP - 1378
SN - 0095-1137
AD - Herwaldt, B. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services Mailstop F-22, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19950805706. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - To assess the role of parasites in causing diarrhoea in Peace Corps volunteers in Guatemala, 115 stool specimens from a case-control investigation (48 cases with diarrhoea and 26 controls) were examined. A potentially pathogenic protozoan that could account for diarrhoea was found in only 6 (12%) of the case specimens: Cyclospora sp. in 3 (6%), Entamoeba histolytica in 1 (2%), Giardia lamblia [Giardia duodenalis] in 1 (2%) and Cryptosporidium in 1 (2%).
KW - diarrhoea
KW - health care workers
KW - human diseases
KW - parasites
KW - protozoal infections
KW - volunteers
KW - Central America
KW - Guatemala
KW - man
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - America
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - diarrhea
KW - protozoal diseases
KW - scouring
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950805706&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - SFE with GC and MS determination of safrole and related allylbenzenes in sassafras teas.
AU - Heikes, D. L.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 1994///
VL - 32
IS - 7
SP - 253
EP - 258
SN - 0021-9665
AD - Heikes, D. L.: Total Diet Research Center, Food and Drug Administration, P.O. Box 15905, Lenexa, Kansas 66285-5905, USA.
N1 - Accession Number: 19950315399. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 97-53-0. Subject Subsets: Human Nutrition; Horticultural Science
N2 - Safrole (4-allyl-1,2-methylenedioxybenzene), a natural plant component of the aromatic oil of sassafras (Sassaras albidum [Sassafras albidum]) root bark, possesses carcinogenic and mutagenic activity. Legal restrictions have been placed on safrole as a food additive in the USA. However, sassafras teas continue to be accessible from health food establishments in the United States. A method using supercritical fluid extraction (SFE) with gas chromatographic-mass spectrometric (GC-MS) is described for the rapid, accurate, and specific determination of safrole and related allylbenzenes in unbrewed sassafras teas. Samples were extracted in a static-dynamic mode with CO2 at 690 bar and 80°C with methanol as an extractor-added modifier. Concentrations of safrole exceeding 10 000 mg/kg (1.0%) were commonly encountered. Lesser amounts of other allylbenzenes, including eugenol and 4-allyl-1,2-dimethoxybenzene, were also detected. Recoveries of safrole and related compounds from previously extracted tea samples fortified at 100 and 1000 mg/kg ranged from 96 to 101%.
KW - bark
KW - essential oil plants
KW - essential oils
KW - eugenol
KW - medicinal plants
KW - phenolic compounds
KW - plant composition
KW - quantitative techniques
KW - roots
KW - Lauraceae
KW - plants
KW - Sassafras albidum
KW - Laurales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Sassafras
KW - Lauraceae
KW - chemical constituents of plants
KW - drug plants
KW - essential oil crops
KW - medicinal herbs
KW - officinal plants
KW - Plant Composition (FF040)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950315399&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of rotavirus G and P types associated with human gastroenteritis in São Paulo, Brazil, from 1986 to 1992.
AU - Timenetsky, M. C. S. T.
AU - Santos, N.
AU - Gouvea, V.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1994///
VL - 32
IS - 10
SP - 2622
EP - 2624
SN - 0095-1137
AD - Timenetsky, M. C. S. T.: Division of Molecular Biological Research and Evaluation. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19952003498. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases
N2 - Rotavirus strains causing gastroenteritis in Brazilian children were characterized by PCR-based typing assays. In addition to strains bearing the major human G and P types, large numbers of strains bearing P3 (M37-like), P6 (HCR3-like), untypable P and G types, and complex mixtures of P and G types not previously recognized were present in the community.
KW - children
KW - diarrhoea
KW - disease prevalence
KW - epidemiology
KW - gastroenteritis
KW - human diseases
KW - infections
KW - Brazil
KW - South America
KW - man
KW - rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - diarrhea
KW - scouring
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952003498&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Industries and occupations at high risk for work-related homicide.
AU - Castillo, D. N.
AU - Jenkins, E. L.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1994///
VL - 36
IS - 2
SP - 125
EP - 132
SN - 0096-1736
AD - Castillo, D. N.: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Mail Stop 180, Morgantown, WV 26505, USA.
N1 - Accession Number: 19952006423. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - A study in the USA in 1980-1989.
KW - homicide
KW - mortality
KW - occupational health
KW - occupations
KW - risk factors
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - death rate
KW - murder
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006423&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality patterns of US female construction workers by race, 1979-1990.
AU - Robinson, C. F.
AU - Burnett, C. A.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1994///
VL - 36
IS - 11
SP - 1228
EP - 1233
SN - 0096-1736
AD - Robinson, C. F.: Surveillance Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 19952004238. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - In 1990, the USA construction industry employed 7.6 million workers, of whom 8% were women. Only one epidemiological study for women employed in the construction industry was previously published. The authors analysed usual occupation and industry codes on death certificates from 28 states between 1979 and 1990 to evaluate mortality patterns among both black and white female construction industry workers. Proportionate mortality for cancer and several other chronic diseases was significantly elevated among 2273 white female and 197 black female construction workers. White women younger than age 65 at death had significantly elevated proportionate mortality ratios (PMRs) for all cancer, lung cancer, and traumatic fatalities. Black women younger than age 65 at death had a significantly elevated PMR for traumatic fatalities. Elevated mortality for specific cancer sites and other diseases was observed for white and black women employed in construction trades. These results suggest that more detailed investigations that include women and other minorities should be undertaken.
KW - construction workers
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupations
KW - women
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - building workers
KW - death rate
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Women (UU500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004238&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure to biogenic silica fibers and respiratory health in Hawaii sugarcane workers.
AU - Sinks, T.
AU - Hartle, R.
AU - Boeniger, M.
AU - Mannino, D.
AU - Boyd, J. E.
AU - Fernback, J.
AU - Hawkins, M.
AU - Grimes, G.
AU - Watkins, K. L.
AU - Dill, P.
AU - Anderson, B.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1994///
VL - 36
IS - 12
SP - 1329
EP - 1334
SN - 0096-1736
AD - Sinks, T.: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 19952004200. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - The authors conducted a cross-sectional environmental and medical survey of 355 male sugarcane workers in Hawaii to determine whether exposure to biogenic silica fibres (BSF) affected their respiratory health. Exposures to BSF ranged from nondetectable to more than 0.700 BSF/ml and varied by job and department. Respiratory symptoms, chest radiograph findings, and pulmonary function were not associated with BSF exposures. Cigarette smoking was associated with respiratory symptoms and pulmonary obstruction. Fifteen workers had pleural thickening or pleural plaques and 3 of these workers were exposed to BSF for more than 10 years. BSF exposure dose not appear to influence the respiratory health of sugarcane workers.
KW - exposure
KW - farm workers
KW - human diseases
KW - occupational hazards
KW - occupations
KW - respiratory diseases
KW - silica
KW - sugarcane
KW - Hawaii
KW - Oceania
KW - man
KW - Saccharum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Polynesia
KW - Oceania
KW - Pacific Islands
KW - lung diseases
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004200&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation, structural determination, and biological activity of 6α-hydroxytaxol, the principle human metabolite of taxol.
AU - Harris, J. W.
AU - Katki, A.
AU - Anderson, L. W.
AU - Chmurny, G. N.
AU - Paukstelis, J. V.
AU - Collins, J. M.
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
Y1 - 1994///
VL - 37
IS - 5
SP - 706
EP - 709
SN - 0022-2623
AD - Harris, J. W.: Division of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19940310524. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 33069-62-4. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - Taxol, a diterpenoid antineoplastic agent isolated from the Pacific Yew [Taxus brevifolia], was given to a patient as a 24 h intravenous infusion. The principle biotransformation product, detected in the bile, was 6α-hydroxytaxol. The structure of 6α-hydroxytaxol was elucidated from spectral data. 6α-Hydroxytaxol was less cytotoxic (IC50 values of 53 and 29 nM against MOLT-4 and U-937 human cell lines) than taxol (IC50 values of 1.6 and 1.0 nM, respectively). 6α-Hydroxytaxol is not detected in rats.
KW - cell lines
KW - chemical structure
KW - cytotoxic compounds
KW - cytotoxicity
KW - diterpenoid alkaloids
KW - diterpenoids
KW - metabolites
KW - paclitaxel
KW - pharmacokinetics
KW - spectral analysis
KW - man
KW - rats
KW - Taxaceae
KW - Taxus brevifolia
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Taxopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - Taxus
KW - Taxaceae
KW - biotransformation
KW - taxol
KW - Plant Composition (FF040)
KW - Non-wood Forest Products (KK540)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940310524&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Qualities of an ideal volunteer community malaria worker: a comparison of the opinions of community residents and national malaria service staff.
AU - Ruebush, T. K., II
AU - Weller, S. C.
AU - Klein, R. E.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 1994///
VL - 39
IS - 1
SP - 123
EP - 131
SN - 0277-9536
AD - Ruebush, T. K., II: Medical Entomology Research and Training Unit-Guatemala, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950801461. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Since the late 1950s, most malaria surveillance and treatment in rural areas of Latin America has been carried out by networks of unpaid community malaria workers, known as Volunteer Collaborators, who are selected and supervised by staff of the national malaria services (NMSs) in each country. To identify ways in which the Volunteer Collaborator Network could be made more attractive to residents and to improve the process of selection of new workers, community residents and Guatemalan NMS workers were asked to rank order, according to their importance, 11 qualities or characteristics of an 'ideal' volunteer malaria worker. Community residents preferred someone who is available to take care of patients at all times of the day, is a responsible person, and has a general knowledge of medicine. No significant differences were noted in the rank orders of male and female residents or literate and illiterate residents. National Malaria Service workers also preferred someone who takes care of patients at all times of the day, even when busy. In addition, they wanted individuals who recognize the importance of their work as a Volunteer Collaborator, but choosing volunteers who had a general knowledge of medicine was not important. By modifying the procedures used to select Volunteer Collaborators so as to identify candidates with the qualities preferred by residents, it should be possible to increase acceptance and improve the performance of these volunteer workers.
KW - control
KW - human diseases
KW - malaria
KW - parasites
KW - volunteers
KW - workers
KW - Apicomplexa
KW - man
KW - Plasmodiidae
KW - Plasmodium
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodiidae
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Environmental Pest Management (HH200)
KW - Health Services (UU350)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recommendations for use of the polymerase chain reaction in the diagnosis of Bordetella pertussis infections.
AU - Meade, B. D.
AU - Bollen, A.
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
Y1 - 1994///
VL - 41
IS - 1
SP - 51
EP - 55
SN - 0022-2615
AD - Meade, B. D.: Division of Bacterial Products, HFM-490, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19952000186. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - In May 1993, representatives from a majority of laboratories employing PCR for the detection and identification of Bordetella pertussis held a series of discussions in order to optimise various stages of the technique. Subjects discussed included sample collection and processing, primer selection and PCR conditions, detection systems and controls. They also discussed controls, the validation of the diagnostic system and the use of PCR in clinical trials. The group concluded that PCR could be included in case definition of pertussis provided that rigorous controls for false-positive and false-negative results were employed, >100 negative samples were evaluated prior to employing the method and finally both the test samples and control samples must be treated in a blind fashion so that personnel conducting the tests have no knowledge of the patient.
KW - diagnosis
KW - pertussis
KW - polymerase chain reaction
KW - Belgium
KW - Europe
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - PCR
KW - whooping cough
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952000186&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Typhoid immunization. Recommendations of the advisory committee on immunization practices (ACIP).
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1994///
VL - 43
IS - RR-14
SP - v + 7
EP - v + 7
SN - 0149-2195
AD - U.S Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19952009431. Publication Type: Miscellaneous. Corporate Author: USA, Centers for Disease Control and Prevention Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - The report notes that the incidence of typhoid fever in the USA has declined steadily since 1900 and for the period 1975-84 averaged 464 cases per annum. Of these, 62% occurred among persons who had travelled to other countries. Three typhoid vaccines are currently available for general use in the USA: (1) oral, live attenuated Ty 21a vaccine (Vivotif), (2) Vi capsular polysaccharide vaccine (Typhim Vi), (3) heat-killed, phenolized whole-cell vaccine. A fourth vaccine, the acetone-inactivated whole-cell vaccine is only available to the US armed forces. The evidence for the efficacy of these preparations is discussed. It is concluded that there is considerable uncertainty about the efficacy of Ty 21a vaccine in persons from non-endemic areas who travel to endemic areas. The heat-phenol inactivated vaccine (or similar preparations) has shown an efficacy of 51-77% in field trials over a 2.5-3 year period. Efficacy of the acetone-inactivated vaccine ranges from 75% to 94%. The Vi polysaccharide vaccine has shown 49-87% efficacy in a field trial in Nepal and 30-71% efficacy in a field trial in South Africa. It is not clear what its efficacy would be in persons from non-endemic areas. The use of typhoid vaccine is not recommended in the USA but is recommended for: (1) travellers to areas in which there is a recognized risk of exposure to Salmonella typhi, (2) persons with intimate exposure to a carrier of S. typhi, (3) microbiology workers who frequently handle S. typhi. According to the Committee the parenteral inactivated whole-cell vaccine is more reactogenic but no more effective than Ty 21a or Typhim Vi, so these two are recommended for use if not contraindicated by other factors. The heat-inactivated vaccine can be used in children from the age of 6 months onwards. The Typhim Vi vaccine is approved only for individuals aged 2 years or more and the Ty 21a vaccine is recommended for persons aged 6 years or more. For the heat-phenol inactivated vaccine, the dose is reduced from 0.5 ml to 0.25 ml in children between 6 months and 10 years old. For the other vaccines, the dose schedules for children and adults are the same. The boosting interval for the heat-phenol inactivated vaccine is 3 years, for the Typhim Vi every 2 years, and for Ty 21a vaccine every 5 years. No information is available on the use of one vaccine as a booster for primary immunization with a different vaccine. However, Ty 21a and Typhim Vi are regarded as suitable boosters for persons previously vaccinated with the heat-phenol inactivated vaccine. It is stated that the boosters of the heat-phenol inactivated vaccine but not acetone-inactivated vaccine may be given intradermally. [However, evidence for the efficacy of the intradermal route is limited.]. Adverse reactions to the Ty 21a oral vaccine are infrequent and restricted to transient gastrointestinal disturbance and skin disorders. Fever and headache were reported by 0-5% of the recipients. Fever was reported by 0-1%, headache by 1.5-3% and erythema and/or local induration by up to 7% of recipients of the Vi polysaccharide vaccines. In contrast, the inactivated vaccines produced a much higher rate of adverse reactions: from 6.7 to 24% of recipients reported fever, 9-10% headache and 3-35% severe local pain or swelling. More severe reactions have also been reported occasionally. Contraindications to Ty 21a include the co-administration of antimicrobial agents (including anti-malarial agents) and viral vaccines. However, it is noted that chloroquine in normal doses should not affect the immunogenicity of Ty 21a. Similarly, there is no evidence that immunoglobulin administration should influence the outcome of Ty 21a vaccination. Mainly because of lack of information, this vaccine is not recommended for pregnant women nor for immunocompromised persons including those infected with HIV. [It should be noted that good efficacy data for the Vi polysaccharide and the Ty 21a vaccines do not exist for persons from areas non-endemic for typhoid fever. Therefore, caution should be exercised in recommending the use of these vaccines in situations in which there is a high risk of exposure to infection.]M.J. Corbel
KW - bacterial diseases
KW - guidelines
KW - human diseases
KW - immunization
KW - salmonellosis
KW - typhoid
KW - vaccines
KW - North America
KW - USA
KW - man
KW - salmonella typhi
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - recommendations
KW - Salmonella infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009431&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Addressing emerging infectious disease threats: a prevention strategy for the United States.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1994///
VL - 43
IS - RR-5
SP - 1
EP - 18
SN - 0149-2195
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19950805691. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Protozoology; Public Health; Medical & Veterinary Entomology
N2 - The spectrum of infectious diseases is changing rapidly in conjunction with social and environmental changes. Recent examples of important emerging infectious diseases include prolonged diarrhoeal illness due to waterborne Cryptosporidium: contamination of a municipal water supply in Milwaukee, Wisconsin, USA in spring 1993 affected an estimated 403 000 persons. Imported infections in the USA include Plasmodium, Trypanosoma cruzi and Leishmania tropica. Outside the USA, emerging diseases include dengue (Costa Rica) and yellow fever (Kenya). In partnership with other organizations, the Centers for Disease Control and Prevention (CDC) have developed a strategic plan to address emerging infectious disease threats, consisting of 4 goals which emphasize surveillance, applied research, prevention and control, and public health infrastructure.
KW - control
KW - control programmes
KW - disease control
KW - human diseases
KW - imported infections
KW - infectious diseases
KW - parasites
KW - prevention
KW - public health services
KW - vector-borne diseases
KW - waterborne diseases
KW - USA
KW - Wisconsin
KW - Apicomplexa
KW - Cryptosporidiidae
KW - Cryptosporidium
KW - man
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Eucoccidiorida
KW - Apicomplexa
KW - Cryptosporidiidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - Lake States of USA
KW - communicable diseases
KW - control programs
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Norwalk virus in artificially seeded shellfish and selected foods.
AU - Gouvea, V.
AU - Santos, N.
AU - Carmo Timenetsky, M. do
AU - Estes, M. K.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 1994///
VL - 48
IS - 2/3
SP - 177
EP - 187
SN - 0166-0934
AD - Gouvea, V.: Division of Molecular Biological Research and Evaluation, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19952000828. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition; Public Health
N2 - A rotavirus dsRNA purification protocol was adapted to extract Norwalk ssRNA from artificially contaminated shellfish, and a sensitive reverse transcription-polymerase chain reaction assay for Norwalk virus was devised to identify an estimated 20-200 genomic copies. The technique includes deproteinization with guanidinium isothiocyanate, adsorption of RNA to hydroxyapatite, and sequential precipitation with cetyltrimethylammonium bromide and ethanol. The protocol allows high recovery of viral RNA free of enzymatic inhibitors from oysters, clams, and a variety of food matrices. Norwalk virus sequences were copied and amplified by using primers selected from the polymerase gene. Digestion of the amplified products with restriction enzymes ensured the specificity of the test. This rapid and sensitive assay may significantly improve the prospect for the routine screening of the uncultivatable Norwalk virus in food stuffs.
KW - detection
KW - foods
KW - human diseases
KW - oysters
KW - polymerase chain reaction
KW - seafoods
KW - man
KW - Norwalk virus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Norovirus
KW - Caliciviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced diagnostic efficiency of the polymerase chain reaction by co-amplification of multiple regions of HIV-1 and HIV-2.
AU - Udaykumar,
AU - Heredia, A.
AU - Soriano, V.
AU - Bravo, R.
AU - Epstein, J. S.
AU - Hewlett, I. K.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 1994///
VL - 49
IS - 1
SP - 37
EP - 46
SN - 0166-0934
AD - Udaykumar,: (I.K. Hewlett) Laboratory of Molecular Virology, Division of Transfusion and Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19942050435. Publication Type: Journal Article. Language: English.
KW - assays
KW - HIV infections
KW - HIV-2 infections
KW - laboratory methods
KW - mixed infections
KW - polymerase chain reaction
KW - human immunodeficiency virus infections
KW - laboratory techniques
KW - multiple infections
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942050435&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance of hazardous substance releases and related health effects.
AU - Hall, H. I.
AU - Dhara, V. R.
AU - Kaye, W. E.
AU - Price-Green, P.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 1994///
VL - 49
IS - 1
SP - 45
EP - 48
SN - 0003-9896
AD - Hall, H. I.: Agency for Toxic Substances and Disease Registry, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road, E-31, Atlanta, GA 30333, USA.
N1 - Accession Number: 19942028209. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The public health consequences of hazardous substance releases have not been characterized adequately. In response, therefore, the Agency for Toxic Substances and Disease Registry [in the USA] implemented an active, state-based surveillance system. Information is collected with respect to the events, chemicals, victims, injuries, and evacuations. Five states reported 1249 events during 1990 and 1991. Seventy-two percent of the events occurred at fixed facilities, and 28% of the events were transportation related. In 80% of the events, one chemical was released. The most frequently released chemicals were herbicides, acids, volatile organic compounds, and ammonias. In 204 events, 846 persons were injured and 7 died. Employees were injured more frequently than first responders or the general public. The most frequently reported injuries were respiratory irritation and eye irritation. Evacuations occurred in 14% of the events. These results provide information for preparedness planning and training of first responders and employees. AS
KW - health
KW - monitoring
KW - Pollution
KW - toxic substances
KW - North America
KW - USA
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - environmental pollution
KW - poisons
KW - surveillance systems
KW - United States of America
KW - Pollution and Degradation (PP600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis and mutagenesis in Chinese hamster ovary cells.
AU - James, S. J.
AU - Basnakian, A. G.
AU - Miller, B. J.
JO - Cancer Research (Baltimore)
JF - Cancer Research (Baltimore)
Y1 - 1994///
VL - 54
IS - 19
SP - 5075
EP - 5080
SN - 0008-5472
AD - James, S. J.: Division of Nutritional Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951403590. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Human Nutrition
N2 - 2 Chinese hamster ovary (CHO) cell lines, CHO-AA8 (hemizygous at the aprt locus) and CHO-UV5 (DNA repair-deficient mutant of AA8) were cultured in Ham's F-12 medium or in custom-prepared Ham's F-12 medium lacking folic acid, thymidine and hypoxanthine. Cells cultured acutely in the folate deficient medium exhibited initial growth arrest, followed by a massive cell death and DNA fragmentation into nucleosomal multimers characteristic of apoptosis. Although prolonged culture in the folate deficient medium was cytostatic and lethal to the majority of cells, minor subpopulations in both cell lines failed to initiate cell death, exhibited phenotypic abnormalities, and adapted a selective growth advantage under marginal folate conditions. These "resistant" clones exhibited major alterations in deoxynucleotide pools associated with an increase in mutant frequency at the aprt locus as detected by resistance to cytotoxicity in 8-azaadenosine. The mutation frequency in DNA repair-deficient cells was ~100-fold greater than that in the parental AA8 clones, underscoring the importance of DNA repair under conditions of folate deficiency and nucleotide pool imbalance. The enhanced mutation frequency in the DNA repair-competent folate-deficient cells suggest that DNA repair activity is less effective under folate-deficient conditions. The results add to the evidence relating chronic folate deficiency to genomic instability and carcinogenesis.
KW - apoptosis
KW - folic acid deficiency
KW - in vitro
KW - mutagenesis
KW - nucleotides
KW - hamsters
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 × C3H F1 mice.
AU - James, S. J.
AU - Muskhelishvili, L.
JO - Cancer Research (Baltimore)
JF - Cancer Research (Baltimore)
Y1 - 1994///
VL - 54
IS - 21
SP - 5508
EP - 5510
SN - 0008-5472
AD - James, S. J.: FDA-National Center for Toxicological Research, Division of Nutritional Toxicology, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951406625. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - Although the dysregulation of physiological signals and mechanisms controlling cell proliferation has been a major focus in cancer research, recent evidence suggests that explicit evaluation of apoptosis or physiological cell death may be equally important in understanding multistage carcinogenesis. Dietary restriction of rodents is well known to reproducibly retard development of spontaneous and chemically induced tumours. It was reasoned that the decrease in metabolic and hormonal trophic factors induced with this intervention could promote selective cell deletion via apoptosis. To pursue this possibility, the spontaneous apoptotic rate in liver sections from diet-restricted (DR) and freely-fed (AL) 12-month-old male C57BL/6 × C3H F1 mice, a murine strain known to develop a high incidence of spontaneous liver tumours by 18 months old, was quantified. The identification of hepatocyte apoptotic bodies was facilitated by in situ end-labelling immunohistochemistry. The basal rate of proliferation of hepatocytes was quantified utilising proliferating cell nuclear antigen immunohistochemistry. The incidence of apoptotic bodies and total proliferating cell nuclear antigen-positive cells was enumerated in 14 mice/group by scoring 50 000 random hepatocytes/liver and expressed as the mean incidence/100 cells. When the comparison was made between diet groups, the apoptotic rate was higher in the DR mice relative to the AL mice, while the proliferation rate was lower (P<0.01 and P<0.05, respectively). The increase in spontaneous level of apoptosis and the decrease in proliferation rate in livers of DR mice were associated with a significantly lower rate of spontaneous hepatoma over a 36-month period. Results suggest that energy intake may modulate the basal turnover rates of cell death and proliferation in a direction consistent with a cancer-protective effect in the DR mice and a cancer promoting effect in AL mice.
KW - apoptosis
KW - carcinogenesis
KW - energy deprivation
KW - energy intake
KW - hepatoma
KW - liver
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A sampling and analytical method for the simultaneous determination of multiple organophosphorus pesticides in air.
AU - Kennedy, E. R.
AU - Abell, M. T.
AU - Reynolds, J.
AU - Wickman, D.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1994///
VL - 55
IS - 12
SP - 1172
EP - 1177
SN - 0002-8894
AD - Kennedy, E. R.: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division of Physical Sciences and Engineering, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19951107551. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Agricultural Entomology; Weeds; Medical & Veterinary Entomology
N2 - A sampling and analytical method for organophosphorus pesticides using a combined filter/XAD-2 sorbent sampler and gas chromatography (GC)-flame photometric detection (FPD) was developed. The method was evaluated for 19 organophosphorus pesticides based on the joint Occupational Safety and Health Administration/National Institute for Occupational Safety and Health Standards Completion Program methods evaluation protocol. The evaluation addressed analyte recovery, sampler capacity, sample stability, and precision and accuracy. Additional experiments addressed long-term sample stability (30-day storage), short-term exposure limits, limits of detection, and concn levels down to 0.1 times an exposure limit value. Samples were stable for 30 days of storage under either ambient or refrigerated conditions. Based on this research, all 19 compounds studied can be successfully determined simultaneously using one method with an accuracy of ± 25% of the true value 95 times out of 100.
KW - agricultural entomology
KW - air
KW - analytical methods
KW - atmosphere
KW - determination
KW - environment
KW - gas chromatography
KW - herbicide residues
KW - herbicides
KW - insecticide residues
KW - insecticides
KW - organophosphorus herbicides
KW - organophosphorus insecticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - residues
KW - sampling
KW - techniques
KW - analytical techniques
KW - sampling techniques
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Pollution and Degradation (PP600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enumeration and differentiation of Vibrio parahaemolyticus and Vibrio vilnificus by DNA-DNA colony hybridization using the hydrophobic grid membrane filtration technique for isolation.
AU - Kaysner, C. A.
AU - Abeyta, C., Jr.
AU - Kinneman, K. C.
AU - Hill, W. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 2
SP - 163
EP - 165
SN - 0362-028X
AD - Kaysner, C. A.: Seafood Products Research Center, U.S. Food and Drug Administration, Bothell, Washington, 98041, USA.
N1 - Accession Number: 19951300659. Publication Type: Journal Article. Language: English. Number of References: 12 ref.
N2 - A means of differentiating and enumerating Vibrio parahaemolyticus and Vibrio vulnificus by DNA-DNA colony hybridization directly on HGMF filters is developed. V. parahaemolyticus can be detected by a thd-3-radiolabeled gene probe and V. vulnificus detected by a specific cytotoxin-hemolysin-radiolabeled probe with enumeration directly from autoradiograms. This procedure is more rapid than current techniques allowing enumeration and identification of these two species in samples as diverse as seawater, oyster (Crassostrea gigas), and shrimp (Pandalidae family) within 4 d. Our method is based on a rapid technique (18 h) for isolation and enumeration of V. parahaemolyticus from food using a membrane filtration technique with hydrophobic grid filters (HGMF). With the HGMF method, however, it is now possible to differentiate V. parahaemolyticus from V. vulnificus since on the HGMF-sucrose-based agar used, the two species are indigtinguishable as both species are unable to ferment sucrose. USing a combination of the HGMF and selective gene probes, these two spp. can be differentiated.
KW - biodeterioration
KW - differentiation
KW - DNA hybridization
KW - enumeration
KW - pathogens
KW - techniques
KW - bacteria
KW - Vibrio parahaemolyticus
KW - prokaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Vibrio vulnificus enumeration
KW - Vibrio vulnificus techniques
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951300659&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incurred arsenic residues in chicken eggs.
AU - Donoghue, D. J.
AU - Hairston, H.
AU - Cope, C. V.
AU - Bartholomew, M. J.
AU - Wagner, D. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 3
SP - 218
EP - 223
SN - 0362-028X
AD - Donoghue, D. J.: Pharmacology and Biochemistry Branch, Center For Veterinary Medicine, Food and Drug Administration, Building 328-A, Agricultural Research Center, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19951403168. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-38-2, 9006-50-2. Subject Subsets: Animal Nutrition; Poultry
N2 - Arsanilic acid and roxarsone (nitrophenylarsonic acid) growth promoters were given to laying hens at elemental arsenic concentrations of 14, 28, 56 and 112 mg/kg diet for 10 weeks followed by a 2-week withdrawal period. As residues in egg components were estimated weekly by atomic absorption. As concentrations in eggs were also estimated after 0, 2 or 4 weeks of refrigerated storage (4°C). As residues in egg yolk and albumen increased dose-dependently although the amount of As was much higher (95% of total) in yolk. As concentrations increased within 1 week of treatment, and the highest amounts were obtained between weeks 2 and 4 for yolk samples and by week 1 for albumen samples, except for As 14 mg/kg where highest amounts were reached by the middle of the treatment period. Hens treated with As 112 mg/kg from arsanilic acid produced eggs with As residues exceeding Food and Drug Administration whole egg tolerance level (500 ppb). Eggs subjected to refrigerated storage did not have increased As concentrations in yolk, although, for some treatments, residues increased in albumen.
KW - arsenic
KW - arsenicals
KW - egg albumen
KW - egg yolk
KW - eggs
KW - growth promoters
KW - hens
KW - intake
KW - poultry
KW - residues
KW - sources
KW - toxicity
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arsenic compounds
KW - chickens
KW - domesticated birds
KW - egg white
KW - growth stimulants
KW - yolk
KW - Forage and Feed Products (Non-human) (RR000)
KW - Animal Nutrition (Production Responses) (LL520)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403168&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anisakid parasites, Staphylococcus aureus and Bacillus cereus in sushi and sashimi from Seattle area restaurants.
AU - Adams, A. M.
AU - Leja, L. L.
AU - Jinneman, K.
AU - Beeh, J.
AU - Yuen, G. A.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 4
SP - 311
EP - 317
SN - 0362-028X
AD - Adams, A. M.: Seafood Products Research Center, U.S. Food and Drug Administration, 22201 23rd Drive S.E., P.O. Box 3012, Bothell, Washington 98041-3012, USA.
N1 - Accession Number: 19951300762. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition; Helminthology
N2 - Samples of salmon, tuna, mackerel, and rockfish sushi were analysed for parasites from 32 of the approximately 50 restaurants in the Seattle area (USA) that prepare sushi. The restaurants were sampled up to three times over a 19-month period. Some speciality grocery stores providing restaurants and consumers with sashimi were also sampled. Salmon sushi was most commonly affected with almost 10% of pieces infected with a maximum of 3 nematodes per piece. Only single infections were present in mackerel sushi with frequency of 5%; and tuna and rockfish sushi were free of nematodes. All nematodes were third-stage juveniles of the genus Anisakis. Except for two moribund nematodes, all juveniles from sushi were dead, most likely the result of the practice of using fish that have been previously frozen. The two moribund nematodes were present in one salmon sushi sample, indicating that an incompletely frozen product had been used. For the sashimi, no parasites were found in tuna; however, a live anisakid was found in one collection of rockfish sashimi. Efforts to detect anisakid nematodes with nondestructive methods were unsuccessful. Neither inspection by ultraviolet light nor by candling was effective for salmon sushi. Candling was also ineffective for mackerel but was useful for rockfish and appears to be appropriate for the analysis of tuna sushi. Results of analyses of rice from sushi samples from 19 of the restaurants indicated that the pH levels were at 4.6 or below, and no faecal coliforms were detected. Most of the aerobic plate counts were below log 6, with only 2 between log 6 and log 7. Bacillus cereus and Staphylococcus aureus were detected in rice from six restaurants each, but in no samples were these two organisms found together, and levels were well below those of public health importance.
KW - biodeterioration
KW - contamination
KW - helminths
KW - parasites
KW - pathogens
KW - raw fish
KW - raw foods
KW - rice
KW - sushi
KW - USA
KW - Washington
KW - anisakidae
KW - Anisakis
KW - Bacillus cereus
KW - bacteria
KW - invertebrates
KW - nematoda
KW - Oryza
KW - salmon
KW - Staphylococcus aureus
KW - tuna
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anisakidae
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Staphylococcus
KW - Staphylococcaceae
KW - Scombridae
KW - Perciformes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - Ascaridida
KW - bacterium
KW - nematodes
KW - paddy
KW - parasitic worms
KW - Secernentea
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enumeration of Vibrio parahaemolyticus and Vibrio vulnificus in various seafoods with two enrichment broths.
AU - Hagen, C. J.
AU - Sloan, E. M.
AU - Lancette, G. A.
AU - Peeler, J. T.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 5
SP - 403
EP - 409
SN - 0362-028X
AD - Hagen, C. J.: Food and Drug Administration/PHS/DHHS, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19951300379. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition
N2 - This study compares recoveries of V. parahaemolyticus and V. vulnificus with salt-polymyxin B broth (SPB) and alkaline peptone water (APW) from samples of crab legs, oysters, shrimp, lobster and shark, which were inoculated at 3 levels (~101, 10², 10²010³ and 104-105/g) with each of the pathogens. Six samples of each product were analysed (MPN) with each broth. Inoculated samples of oysters and slurries of crab and lobster were also tested after cold stress (refrigerated at 2 to 4°C, 3 or 7 d, or frozen at -15°C for 21 or 28 d). For each seafood, genometric means of cells recovered with APW were significantly (P<0.05) greater than the corresponding means of recovery with SPB. In addition, 12 of 15 calculated estimates of 50% relative detectable levels (RLD50) were lower (P < 0.05) for APW than for SPB. In these samples, the level of detection by APW was 40 to 32 000 and 6- to 42-fold lower for V. parahaemolyticus and V. vulnificus, resp., than the level of detection by SPB. In cold-stored samples, overall detection of the pathogens was greatly reduced, but APW was also more efficient than SPB in recovering stressed cells.
KW - biodeterioration
KW - crab meat
KW - culture media
KW - enumeration
KW - lobsters
KW - oysters
KW - pathogens
KW - seafoods
KW - sharks
KW - shrimps
KW - techniques
KW - bacteria
KW - Vibrio
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Bivalvia
KW - Mollusca
KW - prokaryotes
KW - Chondrichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Vibrio
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Aquatic Produce (QQ060)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951300379&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of Escherichia coli O157:H7 in mayonnaise and mayonnaise-based sauces at room and refrigerated temperatures.
AU - Weagant, S. D.
AU - Bryant, J. L.
AU - Bark, D. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 7
SP - 629
EP - 631
SN - 0362-028X
AD - Weagant, S. D.: U.S. Food and Drug Administration, Seattle District Laboratory, Bothell, Washington 98041, USA.
N1 - Accession Number: 19951300885. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - Three Escherichia coli O157:H7 (EHEC) strs were inoculated separately into portions of commercially prepared mayonnaise held at 25 or 7°C, then examined periodically for survival of detectable EHEC. Four mayonnaise-based sauces including: (a) mayonnaise-mustard sauce, (b) blue cheese dressing, (c) thousand island dressing and (d) seafood sauce, were each inoculated with one EHEC str. Samples of these sauces were held at 5°C, and assayed periodically for survival of detectable EHEC. Both direct plate count and selective enrichment recovery were employed as assay procedures. Escherichia coli O157:H7 strs, when inoculated and mixed into mayonnaise and stored at 25°C, became undetectable after 72 h storage when assayed by direct plating or by selective enrichment. The same strs inoculated into mayonnaise and stored at 7°C were detectable up to 35 days when assayed by direct plating or by selective enrichment. Escherichia coli O157:H7 inoculated into mayonnaise-based sauces and held at 5°C were detectable past 35 days in three of the four sauces. Loss of EHEC culturability occurred within 3 days in mayonnaise-mustard sauce.
KW - biodeterioration
KW - pathogens
KW - sauces
KW - storage
KW - survival
KW - temperature
KW - bacteria
KW - Escherichia coli
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - E. coli
KW - mayonnaise
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951300885&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hazard assessment of Listeria monocytogenes in the processing of bovine milk.
AU - Peeler, J. T.
AU - Bunning, V. K.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 8
SP - 689
EP - 697
SN - 0362-028X
AD - Peeler, J. T.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street, S.W., Washington DC 20204, USA.
N1 - Accession Number: 19950403155. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Steps in the production of US Grade A cow milk for human consumption were assessed. A cumulative distribution of values, based on published data, was used to evaluate steps for milking, storage, transportation and pasteurization. Conservative estimates of parameters in the distributions were used to compute concentrations and probabilities. Under normal operations, the probability was <2 in 100 that 1 Listeria monocytogenes cell occurs in every 2 USgal milk processed at exactly 71.7°C for 15 s. The probability was <2 in 100 that 1 cell occurs in 3.8 × 1010 USgal milk processed at 74.4°C for 20 s.
KW - cows
KW - efficiency
KW - evaluation
KW - incidence
KW - milk
KW - milk processing
KW - pasteurization
KW - USA
KW - cattle
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - pasteurizing
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Microbial Technology in Food Processing (QQ120)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950403155&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth and toxin production by Clostridium botulinum in sliced raw potatoes under vacuum with and without sulfite.
AU - Solomon, H. M.
AU - Rhodehamel, E. J.
AU - Kautter, D. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1994///
VL - 57
IS - 10
SP - 878
EP - 881
SN - 0362-028X
AD - Solomon, H. M.: Division of Microbiological Studies, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951302018. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition; Horticultural Science; Potatoes
N2 - The ability of Clostridium botulinum type A or B spores to grow and produce toxin in fresh raw potatoes under vacuum with or without sulfite at 22°C was investigated. Fresh, peeled, sliced potatoes, untreated or dipped for 2 min in sulfite (NaHSO3) and drained, were surface-inoculated at several levels with a mixture of C. botulinum spores, either type A or B, and placed in oxygen-impermeable bags (200 g/bag) that were then vacuum-sealed and incubated at room temp. (22°C). Toxicity was tested on days 0, 3, 4, 5 and 6. After incubation, the potatoes were blended and centrifuges, and the milipore-filtered supernatant fluid was injected intraperitoneally into mice. Sensory evaluation, except taste, was also performed. Potatoes inoculated with C. botulinum type A spores, but untreated with NaHSO3 became toxic in 3 days, which coincided with the sensory evaluation, 'Unfit for human consumption'. However, despite inoculum size or residual SO2 levels, potatoes treated with NaHSO3 appeared acceptable for human consumption through day 6, even though they were toxic after 4 days of incubation. Toxicity from type B spores occurred later and in fewer test samples than type A. Again, the potatoes appeared acceptable but were toxic. Thus, although NaHSO3 markedly extended the consumer acceptability of peeled, sliced, raw potatoes at the abuse temp., it did not inhibit outgrowth and toxin production by C. botulinum under these conditions.
KW - biodeterioration
KW - diseases
KW - microbial contamination
KW - packaging
KW - pathogens
KW - potatoes
KW - production
KW - storage
KW - toxins
KW - treatment
KW - tubers
KW - vacuum packaging
KW - bacteria
KW - Clostridium botulinum
KW - Solanum tuberosum
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - bacterium
KW - sulfite
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951302018&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - International dissemination of epidemic Vibrio cholerae by cargo ship ballast and other nonpotable waters.
AU - McCarthy, S. A.
AU - Khambaty, F. M.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1994///
VL - 60
IS - 7
SP - 2597
EP - 2601
SN - 0099-2240
AD - McCarthy, S. A.: Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama 36528, USA.
N1 - Accession Number: 19951302800. Publication Type: Journal Article. Language: English. Number of References: 32 ref.
N2 - In 1991 and 1992, toxigenic Vibrio cholerae 01, serotype Inaba, biotype EI Tor, was recovered from non-potable (ballast, bilge, and sewage) water from five cargo ships docked in ports of the U.S. Gulf of Mexico, USA. Isolates were examined by pulsed-field gel electrophoresis and were shown to be indistinguisable from the Latin American epidemic str., C6707; however, they differed significantly from the endemic Gulf Coast str. (VRL 1984), this sixth-pandemic str. (569-B), and a V. cholerae non-O1 str. isolated from a ship arriving from a foreign port.
KW - biodeterioration
KW - disease transmission
KW - harbours
KW - microbial contamination
KW - pathogens
KW - sea water
KW - sewage
KW - Gulf States of USA
KW - USA
KW - bacteria
KW - Vibrio cholerae
KW - prokaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - harbors
KW - health risk
KW - seawater
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Human Wastes and Refuse (XX300)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of gamma irradiation on shelf life and bacterial and viral loads in hard-shelled clams (Mercenaria mercenaria).
AU - Harewood, P.
AU - Rippey, S.
AU - Montesalvo, M.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1994///
VL - 60
IS - 7
SP - 2666
EP - 2670
SN - 0099-2240
AD - Harewood, P.: Northeast Seafood Laboratory, U.S. Food and Drug Administration, Davisville, North Kingstown, Rhode Island 02852, USA.
N1 - Accession Number: 19951302793. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 7440-48-4. Subject Subsets: Human Nutrition
N2 - The use of 60Co γ irradiation to inactivate total coliforms, fecal coliforms, Escherichia coli, Clostridium perfringens, and F-coliphage in hard-shelled clams (Mercenaria mercenaria) was assessed. The results of three trials indicated average D10 values of 1.32 kGy for total coliforms, 1.39 kGy for fecal coliforms, 1.54 kGy for E. coli, 2.71 kGy for C. perfringens, and 13.50 kGy for F-coliphage. Irradiation doses of >0.5 kGy were significantly lethal to the shellfish.
KW - biodeterioration
KW - cobalt
KW - control
KW - faecal coliforms
KW - foods
KW - gamma radiation
KW - hard clams
KW - irradiation
KW - keeping quality
KW - microbial contamination
KW - pathogens
KW - seafoods
KW - shellfish
KW - bacteria
KW - Clostridium perfringens
KW - Escherichia coli
KW - Mercenaria mercenaria
KW - viruses
KW - clams
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Mercenaria
KW - Veneridae
KW - bacterium
KW - coliforms
KW - E. coli
KW - F-coliphage
KW - fecal coliforms
KW - gamma rays
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Storage Problems and Pests of Food (QQ111)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951302793&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibody-direct epifluorescent filter technique for rapid direct enumeration of Escherichia coli O157:H7 in beef.
AU - Tortorello, M. L.
AU - Stewart, D. S.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1994///
VL - 60
IS - 10
SP - 3553
EP - 3559
SN - 0099-2240
AD - Tortorello, M. L.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, Summit-Agro, Illinois 60501, USA.
N1 - Accession Number: 19951303990. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition
N2 - Escherichia coli O157:H7 was directly enumerated in inoculated ground beef and beef exudate, by the antibody-direct epifluorescent filter technique (Ab-DEFT). The total assay time of the AB-DEFT was <1 h. The beef was homogenized, treated for 15 min with trypsin and Triton X-100, and passed through a 5-µm-pore-size prefilter and then through a 0.2-µm-pore-size black polycarbonate filter. The final filter was stained directly with fluorescein-labeled anti-O157 polyclonal antibody, rinsed, and examined by epifluorescence microscopy. The sensitivity and reliability of the Ab-DEFT was comparable with that of a standard enrichment culture technique determining the presence of the pathogen in beef at 16 c.f.u./g. The Ab-DEFT was also useful for quantifying the pathogen and monitoring its growth in beef.
KW - beef
KW - biodeterioration
KW - detection
KW - filtration
KW - ground beef
KW - pathogens
KW - techniques
KW - bacteria
KW - Escherichia coli
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - antibodies + fluorescence microscopy
KW - bacterium
KW - E. coli
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951303990&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Pseudomonas aeruginosa from clinical and environmental samples by amplification of the exotoxin A gene using PCR.
AU - Khan, A. A.
AU - Cerniglia, C. E.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1994///
VL - 60
IS - 10
SP - 3739
EP - 3745
SN - 0099-2240
AD - Khan, A. A.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951304002. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7732-18-5.
N2 - PCR was used to detect Pseudomonas aeruginosa from water samples without the use of selective media or additional biochemical tests by amplifying a 396-bp region of the exotoxin A (ETA) structural gene sequence. Specific primers amplified ETA-positive P. aeruginosa DNA, whereas other species of Pseudomonas and GC-rich bacteria did not yield any 396-bp fragment. The specificity and sensitivity of the assay were 100 and 96%, resp., which confirmed the assay's reliability for diagnostic and epidemiological studies. The assay was shown to detect as few as 5 to 10 cells in a 10-ml water sample or 0.1 pg of P. aeruginosa DNA per reaction mixture (5 μl) by ethidium bromide straining of an agarose gel. Ten-times-lower concn were detected by hybridization with a digoxigenin-labeled oligonucleotide probe internal to the PCR product. With this PCR method, ETA-positive P. aeruginosa was detected in animal cage water samples at a level of 40 cells per ml. This method is rapid and less cumbersome than other diagnostic methods for the identification of P. aeruginosa strains.
KW - bacterial toxins
KW - biodeterioration
KW - detection
KW - genes
KW - genetic analysis
KW - pathogens
KW - polymerase chain reaction
KW - techniques
KW - water
KW - bacteria
KW - pseudomonas aeruginosa
KW - prokaryotes
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - PCR
KW - Techniques and Methodology (ZZ900)
KW - Genetics (General and Theoretical) (ZZ370) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory history for stearic acid.
AU - Vanderveen, J. E.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1994///
VL - 60
IS - 6(S)
SP - 983S
EP - 985S
SN - 0002-9165
AD - Vanderveen, J. E.: Office of Plant and Dairy Foods and Beverages, US Food and Drug Administration, 200 C Street SW, HFS-300, Washington, DC 20204, USA.
N1 - Accession Number: 19951402724. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 20 ref. Registry Number: 57-11-4. Subject Subsets: Human Nutrition
KW - food legislation
KW - history
KW - stearic acid
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Metabolic consequences of stearic acid relative to other long-chain fatty acids
KW - octadecanoic acid
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
KW - Laws and Regulations (DD500)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951402724&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of malaria parasite development in mosquitoes by anti-mosquito-midgut antibodies.
AU - Lal, A. A.
AU - Schriefer, M. E.
AU - Sacci, J. B.
AU - Goldman, I. F.
AU - Louis-Wileman, V.
AU - Collins, W. E.
AU - Azad, A. F.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1994///
VL - 62
IS - 1
SP - 316
EP - 318
SN - 0019-9567
AD - Lal, A. A.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950507949. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - The mosquito midgut plays a central role in the development and subsequent transmission of malaria parasites. Using a rodent malaria parasite, Plasmodium berghei, and the mosquito vector Anopheles stephensi, the authors investigated the effect of anti-mosquito-midgut antibodies on the development of malaria parasites in the mosquito. In agreement with previous studies, it was found that mosquitoes that ingested anti-midgut antibodies along with infectious parasites had significantly fewer oocysts than mosquitoes in the control group. It was also found that the anti-midgut antibodies inhibit the development and/or translocation of the sporozoites. Together, these observations open an avenue for research toward the development of a vector-based malaria parasite transmission-blocking vaccine.
KW - antibodies
KW - disease vectors
KW - midgut
KW - oocysts
KW - parasites
KW - sporozoites
KW - transmission blocking immunity
KW - Anopheles stephensi
KW - Culicidae
KW - Diptera
KW - Plasmodium berghei
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507949&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monoclonal antibodies to the circumsporozoite protein repeats of a Plasmodium vivax-like human malaria parasite and Plasmodium simiovale..
AU - Udhayakumar, V.
AU - Qari, S. H.
AU - Patterson, P.
AU - Collins, W. E.
AU - Lal, A. A.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1994///
VL - 62
IS - 5
SP - 2098
EP - 2100
SN - 0019-9567
AD - Udhayakumar, V.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19940804790. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology
N2 - A Plasmodium vivax-like human malaria parasite has recently been described. The circumsporozoite protein of this parasite is identical to that of P. simiovale, but different from 2 known types of P. vivax. The production of 2 MAbs, Pam 172 and Pam 135, specific for the circumsporozoite protein repeat sequence APGANQEGGAA of the P. vivax-like malaria parasite is described. These 2 MAbs recognized air-dried sporozoites of P. simiovale but not other human, simian, or rodent malaria parasites tested.
KW - chemotaxonomy
KW - circumsporozoite protein
KW - human diseases
KW - molecular genetics
KW - monoclonal antibodies
KW - new species
KW - parasites
KW - sporozoites
KW - taxonomy
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium
KW - Plasmodium simiovale
KW - Plasmodium vivax
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium
KW - biochemical genetics
KW - biochemical taxonomy
KW - systematics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Superoxide anion production in response to bacterial lipopolysaccharide and fungal spores implicated in organic dust toxic syndrome.
AU - Shahan, T. A.
AU - Sorenson, W. G.
AU - Lewis, D. M.
JO - Environmental Research (New York)
JF - Environmental Research (New York)
Y1 - 1994///
VL - 67
IS - 1
SP - 98
EP - 107
SN - 0013-9351
AD - Shahan, T. A.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19951200045. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - In order to determine the aetiopathogenesis for organic dust toxic syndrome, the activation of guineapig bronchial alveolar lavage (BAL) cells was investigated by studying the production of superoxide anion in response to fungal spores and lipopolysaccharide (LPS). Spores from Aspergillus candidus, A. terreus, A. niger, A. fumigatus, Eurotima amstelodami [Eurotium amstelodami], Penicillium spinulosum and Cladosporium cladosporioides all increased superoxide anion production, each with different potencies. LPS stimulated little superoxide anion production in BAL cells, but when cells were pre-treated with LPS prior to stimulation with fungal spores, superoxide anion production was increased over that induced by either spores or LPS alone. It is suggested that the inhalation of LPS together with fungal spores could provoke abnormal lung pathologies.
KW - allergies
KW - lipopolysaccharides
KW - Aspergillus candidus
KW - Aspergillus fumigatus
KW - Aspergillus niger
KW - Aspergillus terreus
KW - Cladosporium cladosporioides
KW - guineapigs
KW - Mycosphaerellaceae
KW - Trichocomaceae
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Cladosporium
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Eurotium
KW - Mycosphaerella
KW - Mycosphaerellaceae
KW - Penicillium
KW - Eurotium amstelodami
KW - fungus
KW - guinea pigs
KW - Hyphomycetes
KW - mitosporic fungi
KW - Mycosphaerella tassiana
KW - organic dust toxic syndrome
KW - Penicillium spinulosum
KW - superoxide anions
KW - Weeds and Noxious Plants (FF500)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951200045&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization.
AU - Bou-Habib, D. C.
AU - Roderiquez, G.
AU - Oravecz, T.
AU - Berman, P. W.
AU - Lusso, P.
AU - Norcross, M. A.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1994///
VL - 68
IS - 9
SP - 6006
EP - 6013
SN - 0022-538X
AD - Bou-Habib, D. C.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Building 29A, Room 3B10, 8800 Rockville Pike, HFM-541, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952001717. Publication Type: Journal Article. Language: English. Number of References: 45 ref.
KW - conformation
KW - epitopes
KW - human diseases
KW - human immunodeficiency viruses
KW - neutralizing antibodies
KW - pathogenesis
KW - phenotypes
KW - tropisms
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - antigenic determinants
KW - body conformation
KW - human immunodeficiency virus
KW - V3 loop
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001717&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular evolution and epidemiology of dengue-3 viruses.
AU - Lanciotti, R. S.
AU - Lewis, J. G.
AU - Gubler, D. J.
AU - Trent, D. W.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1994///
VL - 75
IS - 1
SP - 65
EP - 75
SN - 0022-1317
AD - Lanciotti, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 20087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950500958. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology
N2 - The nucleic acid sequences of the pre-membrane/membrane and envelope protein genes of 23 geographically and temporally distinct dengue (DEN)-3 viruses were determined. This was accomplished by reverse transcriptase-PCR amplification of the structural genes followed by automated DNA sequence analysis. Comparison of nucleic acid sequences revealed that similarity among the viruses was >90%. The similarity among deduced amino acids was between 95% and 100%, and in many cases identical amino acid substitutions occurred among viruses from similar geographical regions. Alignment of nucleic acid sequences followed by parsimony analysis allowed the generation of phylogenetic trees, demonstrating that geographically independent evolution of DEN-3 viruses had occurred. The DEN-3 viruses were separated into 4 genetically distinct subtypes. Subtype I consists of viruses from Indonesia, Malaysia, the Philippines and the South Pacific islands; subtype II consists of viruses from Thailand; subtype III consists of viruses from Sri Lanka, India, Africa (Mozambique) and Samoa; subtype IV consists of viruses from Puerto Rico and the 1965 Tahiti virus. Phylogenetic analysis has also contributed to the understanding of the molecular epidemiology and worldwide distribution of DEN-3 viruses.
KW - arboviruses
KW - dengue
KW - DNA
KW - epidemiology
KW - molecular genetics
KW - nucleotide sequences
KW - viral proteins
KW - Fiji
KW - French Polynesia
KW - India
KW - Indonesia
KW - Malaysia
KW - Mozambique
KW - Philippines
KW - Puerto Rico
KW - Samoa
KW - Sri Lanka
KW - Tahiti
KW - Thailand
KW - dengue virus
KW - Flavivirus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - ACP Countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - Melanesia
KW - Australasia
KW - Oceania
KW - Pacific Islands
KW - France overseas
KW - Polynesia
KW - South Asia
KW - Asia
KW - APEC countries
KW - ASEAN Countries
KW - South East Asia
KW - Threshold Countries
KW - Least Developed Countries
KW - Portuguese Speaking Africa
KW - Africa
KW - SADC Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - Society Islands
KW - French Polynesia
KW - arthropod-borne viruses
KW - biochemical genetics
KW - Ceylon
KW - deoxyribonucleic acid
KW - DNA sequences
KW - molecular evolution
KW - Porto Rico
KW - Western Samoa
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950500958&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of chloramphenicol residues in bovine milk by gas chromatography/mass spectrometry.
AU - Kijak, P. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 1
SP - 34
EP - 40
SN - 1060-3271
AD - Kijak, P. J.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Bldg 328-A, BARC-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19950401230. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 56-75-7. Subject Subsets: Human Nutrition; Dairy Science
N2 - A GC/MS method was developed to confirm the presence of chloramphenicol (CAP) at 0.5 ng/ml in bovine milk. meta-Nitrochloramphenicol (20 ng) is added to 10 ml milk as a surrogate standard. The milk is mixed with ethyl acetate and then loaded onto a diatomaceous earth-filled, solid-phase extraction (SPE) column; CAP is eluted with additional ethyl acetate. A solution of 4% NaCl in water is added to the eluant, and ethyl acetate is removed by evaporation under a flow of N2. The sample is defatted with hexane and then loaded onto a C18-SPE column. The column is washed with water and CAP is eluted with methanol. The methanol is evaporated under a flow of N2, and the trimethylsilyl derivative is prepared with Sylon HTP (hexamethyldisilazane-trimethylchlorosilane-pyridine, 3 + 1 + 9). The excess reagent is evaporated under N2, and the residue is taken up in cyclohexane-hexane (60 + 40). CAP is separated on a 30 m × 0.25 mm id methylsilicone column having a film thickness of 0.25 µm and analysed by methane negative chemical ionization with selected ion monitoring. Confirmation is based on the presence of 5 ions with relative ion abundances within 10% of that obtained using standards.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - chloramphenicol
KW - chromatography
KW - cows
KW - detection
KW - drug residues
KW - drugs
KW - gas chromatography
KW - mass spectrometry
KW - milk
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Wide-bore capillary gas chromatographic determination of organophosphorous pesticide residues in foods: interlaboratory trial.
AU - Parfitt, C. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 1
SP - 92
EP - 100
SN - 1060-3271
AD - Parfitt, C. H.: US Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204, USA.
N1 - Accession Number: 19951102884. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Horticultural Science; Agricultural Entomology; Postharvest Research; Potatoes
N2 - Wide-bore capillary columns are often used as alternatives to traditionally packed columns for gas chromatographic (GC) determination of pesticide residues in foods. Fused silica columns with cross-linked, bonded stationary phases are reproducible, non-delicate and easy to use and are substantially more inert than their packed column equivalents. An interlaboratory trial was conducted in 5 laboratories to determine the practicability of using isothermal wide-bore capillary GC as an alternative to packed column GC systems for determining pesticide residues in foods. Two wide-bore capillary columns with flame photometric detection were evaluated with respect to the following: linearity of detector responses; repeatability of response for equal and unequal injection volumes of standard solutions; accuracy of quantifying pesticides in food extracts when the injection volumes or analyte concn of the standard solution and the food extract were different; recoveries of 23 pesticides from 5 fortified food extracts (bell peppers [Capsicum], lettuce, tomatoes, strawberries and potatoes), calculated from both duplicate and single injections; and relative retention times. Before shipment, food extracts supplied to participants were fortified with pesticides after preparation and extraction of foods. The performance of wide-bore capillary columns with cross-linked bonded methyl silicone and methyl phenyl silicone stationary phases was equal or superior to that of the packed columns specified in the Official Method of the AOAC.
KW - agricultural entomology
KW - commodities
KW - determination
KW - fruit vegetables
KW - leafy vegetables
KW - lettuces
KW - methodology
KW - nontarget effects
KW - pesticide residues
KW - pesticides
KW - potatoes
KW - residues
KW - root crops
KW - small fruits
KW - stored products
KW - strawberries
KW - techniques
KW - tomatoes
KW - tubers
KW - vegetables
KW - Capsicum
KW - Fragaria
KW - Lactuca sativa
KW - Solanum
KW - Solanum lycopersicum
KW - Solanum tuberosum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - Solanum
KW - green vegetables
KW - Lycopersicon
KW - Lycopersicon esculentum
KW - methods
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening of organochlorine pesticide and polychlorinated biphenyl residues in nonfatty seafood products by tandem solid-phase extraction cleanup.
AU - Schenck, F. J.
AU - Wagner, R.
AU - Hennessey, M. K.
AU - Okrasinski, J. L., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 1
SP - 102
EP - 106
SN - 1060-3271
AD - Schenck, F. J.: US Food and Drug Administration, Baltimore District, 900 Madison Ave., Baltimore, MD 21201, USA.
N1 - Accession Number: 19950501567. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 57-74-9, 12789-03-6, 50-29-3, 60-57-1, 72-20-8, 608-73-1, 76-44-8, 58-89-9. Subject Subsets: Medical & Veterinary Entomology; Human Nutrition; Agricultural Entomology
N2 - A rapid multiresidue solid-phase extraction (SPE) technique for the isolation and subsequent gas chromatographic (GC) determination of organochlorine (OC) pesticide and polychlorinated biphenyl (PCB) residues in nonfatty fish, crabmeat, shrimp and scallops is described. Samples are extracted with acetonitrile, and the extract is subjected to a cleanup using both C18 and Florisil SPE columns. The residues are determined by GC with electron capture detection. Because the injected extracts are free from matrix interferences, the amount of residue present is easily calculated. The average recoveries of 9 spiked (0.01-0.40 ppm) OC pesticide residues from 6 different seafood products ranged from 93.8 to 98.4%. The average recoveries of spiked (0.50 ppm) PCB mixtures from 4 different seafood products ranged from 88.5 to 107.2%. This SPE method and the AOAC multiresidue method for OC residues in fish produced comparable results for nonfatty seafood samples containing incurred OC pesticide and PCB residues. The SPE method reduces organic solvent consumption by 95% and hazardous waste by 85% compared with the AOAC method. 10 seafood samples were carried through the extraction and cleanup in <2 h by using the SPE method.
KW - agricultural entomology
KW - analysis
KW - analytical methods
KW - chlordane
KW - DDT
KW - dieldrin
KW - endrin
KW - fish
KW - foods
KW - gas chromatography
KW - HCH
KW - heptachlor
KW - insecticide residues
KW - insecticides
KW - lindane
KW - marine environment
KW - marine fishes
KW - organochlorine insecticides
KW - pesticide residues
KW - polychlorinated biphenyls
KW - residues
KW - scallops
KW - seafoods
KW - shellfish
KW - shrimps
KW - techniques
KW - crabs
KW - fishes
KW - Pectinidae
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - vertebrates
KW - Chordata
KW - analytical techniques
KW - benzene hexachloride
KW - BHC
KW - dicophane
KW - nonachlor
KW - PCBs
KW - sea fishes
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Iron milk medium method for recovering Clostridium perfringens from shellfish: collaborative study.
AU - Abeyta, C., Jr.
AU - Wetherington, J. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 2
SP - 351
EP - 356
SN - 1060-3271
AD - Abeyta, C., Jr.: US Food and Drug Administration, Seafood Product Research Center, 22201 23rd Dr, S E, Bothell, WA 98041, USA.
N1 - Accession Number: 19940405572. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 7439-89-6. Subject Subsets: Dairy Science; Human Nutrition
N2 - 11 laboratories participated in a collaborative study analysing shellfish (oysters, Crassostrea gigas) for the detection and enumeration of Clostridium perfringens by the iron milk medium (IMM) method. The IMM method was compared with AOAC Official Method 976.30. Shellfish were artificially inoculated with C. perfringens cells (vegetative and spores) at low (1 × 10³ c.f.u./g), medium (1 × 104 c.f.u./g) and high (1 × 106 c.f.u./g) levels. Negative controls (zero level) were analysed by each laboratory. C. perfringens FD-1, the strain involved in a foodborne illness, was used. Blind duplicates of each inoculum level were analysed, giving a total of 16 samples per laboratory. The selectivity of IMM relies solely on the rapid growth of C. perfringens at 45°C, indicated by stormy fermentation reaction within 18 h. C. perfringens is detected and enumerated using the MPN technique. A statistical evaluation of the data found no significant differences between the estimates from the 2 methods. The IMM method for detection of C. perfringens from shellfish has been adopted first action by AOAC International.
KW - cows
KW - culture media
KW - estimation
KW - foods
KW - iron
KW - milk
KW - oysters
KW - recovery
KW - shellfish
KW - cattle
KW - Clostridium perfringens
KW - Crassostrea gigas
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Crassostrea
KW - Ostreidae
KW - Homo
KW - Hominidae
KW - Primates
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Visual screening with enzyme immunoassay for staphylococcal enterotoxins in foods: collaborative study.
AU - Bennet, R. W.
AU - McClure, F.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 2
SP - 357
EP - 364
SN - 1060-3271
AD - Bennet, R. W.: US Food and Drug Administration, Division of Microbiology, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19940405573. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Selected foods containing 4-10 ng each of a mixture of Staphylococcus aureus enterotoxin serotypes A-E were tested by 15 collaborators. An ELISA was used with polyvalent antisera to these serotypes in a polyclonal antibody double 'sandwich' configuration. Controls were free of toxin. Foods (25-g test samples) were homogenized with Tris (0.25 M, pH 8.0) and centrifuged. The food extract was filtered through cotton and mixed with sample additive. For the ELISA, 200 µl aliquots of the treated extracts were added to previously washed microtitre wells coated with antibody to staphylococcal enterotoxin serotypes A-E. Wells were washed and treated with the polyvalent antisera (A-E)-enzyme conjugate, and then washed again. Substrate was added and wells were incubated. After incubation, stop solution was added. Results were determined visually and by measuring absorbance using a microtitre plate reader. In foods containing enterotoxin, bluish-green colour was developed (positive result). Test solutions with absorbances >0.200 were considered positive; those with absorbances ≤0.200 were negative. The method is sensitive and specific, and allows the rapid assay of staphylococcal enterotoxins in foods without differentiating their serotypes. The method has been adopted first action by AOAC International. Foods tested included mushrooms, skim milk, beef/pasta, lobster bisque and chicken.
KW - analytical methods
KW - chicken meat
KW - cows
KW - edible fungi
KW - ELISA
KW - enterotoxins
KW - foods
KW - meat products
KW - mushrooms
KW - poultry
KW - screening
KW - seafoods
KW - skim milk
KW - cattle
KW - fowls
KW - fungi
KW - man
KW - Staphylococcus aureus
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Homo
KW - Hominidae
KW - Primates
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - chickens
KW - domesticated birds
KW - enzyme linked immunosorbent assay
KW - screening tests
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of the presence of Listeria monocytogenes in milk and dairy products: IDF collaborative study.
AU - Twedt, R. M.
AU - Hitchins, A. D.
AU - Prentice, G. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 2
SP - 395
EP - 402
SN - 1060-3271
AD - Twedt, R. M.: Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19940405576. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - A collaborative study was conducted on the recovery of viable Listeria monocytogenes from milk and milk products (Camembert cheese, Limburg cheese, dried skim milk and ice cream). Test portions were homogenized with Listeria-selective liquid enrichment medium and cultured at 30°C for 48 h. The enrichment culture was then subcultured onto a solid isolation medium at 37°C for 48 h. Suspected Listeria colonies were identified by appropriate conventional morphological, physiological and biochemical tests. Five kinds of dairy matrices were spiked with L. monocytogenes at 2 levels: 12 and 120 c.f.u./25 g. Each of the 18 collaborating laboratories analysed 15 blind test portions from each matrix, comprising 5 replicates at each spiking level and 5 uninoculated controls, for a total of 1350 analyses. The specificity of the method was 100%; its sensitivity was 94-100% at the high spiking level and 89-98% at the low spiking level, except for Limburg cheese, which was only 68%. No specificity or sensitivity differences were observed between laboratories for all matrices at the high spiking level and for all except Limburg cheese at the low spiking level. The calculated 50% detection limit for all products except Limburg cheese was 1.6 c.f.u./25 g; the 50% detection limit for Limburg cheese itself was 4.1 c.f.u./25 g. The method was adopted first action by AOAC International.
KW - analytical methods
KW - Camembert cheese
KW - cows
KW - determination
KW - dried milk
KW - dried skim milk
KW - ice cream
KW - International Dairy Federation
KW - Limburg cheese
KW - milk
KW - milk products
KW - skim milk
KW - cattle
KW - Listeria monocytogenes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - dairy products
KW - milk powder
KW - nonfat dry milk
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Solvent-efficient thin-layer chromatographic method for the determination of aflatoxins B1, B2, G1, and G2 in corn and peanut products: collaborative study.
AU - Park, D. L.
AU - Trucksess, M. W.
AU - Nesheim, S.
AU - Stack, M.
AU - Newell, R. F.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 3
SP - 637
EP - 646
SN - 1060-3271
AD - Park, D. L.: Division of Contaminants Chemistry, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941201319. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Animal Nutrition; Maize; Postharvest Research
N2 - An interlaboratory study of a solvent-efficient thin layer chromatographic (TLC) method for the determination of aflatoxins B1, B2, G1 and G2 was conducted in laboratories in the USA, France, Tunisia and Denmark. 18 artificially contaminated samples plus blanks of raw groundnuts, groundnut butter and maize containing varying amounts of aflatoxins B1, B2, G1 and G2 were tested. Methods with reduced solvent requirements were used and laboratories used either visual or densitometric techniques during the final determinative step. Data were statistically analysed to determine or confirm outliers and to compute repeatability and reproducibility of the method using either visual or densitometric techniques for the determinative step. For maize samples, using a densitometer, the relative standard deviation for repeatability (RSDr) for aflatoxin B1 ranged from 56.6 to 41.7% for contamination levels of 5-50 ng/g. For groundnuts and peanut butter, the RSDr values for aflatoxin B1 ranged from 21.3 to 37.3% and 65.9 to 42.1%, respectively, for the contamination levels of 5-25 ng/g. RSDr ranges for aflatoxins B2, G1 and G2 were similar. For reproducibility (R), the RSDR ranges for aflatoxin B1 were 41.7-56.6%, 56.6-84.4% and 26.4-37.3% for maize, groundnut butter and groundnuts, respectively. Mean recoveries for all aflatoxins at all levels were 95.3, 139.0, and 95.6% for maize, groundnut butter and groundnuts, respectively. When aflatoxin concn in maize were determined by visual comparison to standards, the RSDr values for aflatoxin B1 were 47.8-11.4% for contamination levels of 5 to 50 ng/g. For groundnuts and groundnut butter, the RSDr values for aflatoxin B1 were 76.3-12.6% and 33.4-8.8%, respectively, for contamination levels of 5 to 25 ng/g. RSDr values for aflatoxins B2, G1 and G2 were similar. The RSDR values for aflatoxin B1 were 34.6-90.2%, 45.5-59.3% and 31.8-78.3% for maize, groundnut butter and groundnuts, respectively. Mean recoveries for all aflatoxins at all levels were 111.0, 157.6 and 92.3% for maize, groundnut butter and groundnuts, respectively. High recoveries were noted for aflatoxins in groundnut butter determined by either a densitometer or comparison with standards. Generally, increased precision was observed with the method at higher contamination levels. On the basis of these results, the solvent-efficient TLC method using densitometry for the quantitative step for determination of aflatoxins B1, B2, G11 and G2 in maize and groundnuts was adopted first action by AOAC.
KW - aflatoxins
KW - analytical methods
KW - contamination
KW - determination
KW - estimation
KW - groundnut butter
KW - groundnuts
KW - maize
KW - mycotoxins
KW - thin layer chromatography
KW - USA
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - corn
KW - fungal toxins
KW - peanut butter
KW - peanuts
KW - United States of America
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enzyme-linked immunosorbent assay of total aflatoxins B1, B2 and G1 in corn: follow-up collaborative study.
AU - Trucksess, M. W.
AU - Stack, M. E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 3
SP - 655
EP - 658
SN - 1060-3271
AD - Trucksess, M. W.: Division of Contaminants Chemistry, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19941201320. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Animal Nutrition; Maize; Postharvest Research
N2 - A direct competitive ELISA screening method for aflatoxins at 20 ng/g in maize was tested by 15 collaborating laboratories. Test samples of maize were extracted by blending with methanol-water (8+2). The extracts were filtered and the filtrates were diluted with buffer to a final methanol concn of <30%. Each diluted filtrate was applied to a test device containing a filter with immobilized polyclonal antibodies specific to aflatoxins B1, B2 and G1. Aflatoxin B1-peroxidase conjugate was added, the test device was washed with water, and a mixture of hydrogen peroxide and tetramethylbenzidine was added. Test samples were judged to contain ≥20 ng/g aflatoxins when, after exactly 1 min, no colour was observed on the filter; if a blue or grey colour developed, samples were judged to contain <20 ng/g aflatoxins. All laboratories correctly identified naturally contaminated maize test samples. Only 1 false positive was found for controls containing no aflatoxins. The correct responses for positive test samples spiked at levels of 10, 20 and 30 ng/g aflatoxins (the ratio of B1:B2:G1 was 15:1:3) were 67, 97 and 100%, respectively. This method was adopted first action for screening for aflatoxins B1, B2 and G1 in maize at total aflatoxin concn of ≥20 ng/g.
KW - aflatoxins
KW - analytical methods
KW - contamination
KW - determination
KW - ELISA
KW - estimation
KW - maize
KW - mycotoxins
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - corn
KW - enzyme linked immunosorbent assay
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for determination of triglycerides in vegetable oils in terms of their partition numbers: summary of collaborative study.
AU - Firestone, D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 4
SP - 954
EP - 957
SN - 1060-3271
AD - Firestone, D.: US Food and Drug Administration, Division of Pesticides and Industrial Chemicals, HFS-336, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951403388. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 8001-22-7, 8001-21-6. Subject Subsets: Human Nutrition; Soyabeans
N2 - The IUPAC Commission on Oils, Fats and Derivatives undertook development of a method and collaborative study for the determination of triglycerides in vegetable oils by liquid chromatography. Three collaborative studies were conducted from 1985 to 1987. Refinements were made in the method after the first collaborative study, and the second and third collaborative studies demonstrated that the method produces acceptable results for soyabean oil, almond oil, sunflower oil, olive oil, rapeseed oil, and blends of palm and sunflower oils, and almond and sunflower oils. 6 test samples were analysed by 18 laboratories from 11 countries in the second study; 4 test samples were analysed by 16 laboratories from 12 countries in the third study. The method for determination of triglycerides (by partition numbers) in vegetable oils by liquid chromatography was adopted first action by AOAC International as an IUPAC-AOCS-AOAC method.
KW - almond oil
KW - analytical methods
KW - determination
KW - liquid chromatography
KW - olive oil
KW - palm oils
KW - plant oils
KW - rapeseed oil
KW - soyabean oil
KW - sunflower oil
KW - techniques
KW - triacylglycerols
KW - analytical techniques
KW - soybean oil
KW - triglycerides
KW - vegetable oils
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gel-permeation liquid chromatographic method for determination of polymerized triglycerides in oils and fats: summary of collaborative study.
AU - Firestone, D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 4
SP - 957
EP - 960
SN - 1060-3271
AD - Firestone, D.: US Food and Drug Administration, Division of Pesticides and Industrial Chemicals, HFS-336, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951403389. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition
N2 - The IUPAC Commission on Oils, Fats and Derivatives undertook development of a method and collaborative study for determination of polymerized triglycerides in oils and fats. Two collaborative studies were carried out by IUPAC in 1985 and 1986. Both studies used animal fat, frying oil with average content of polymers, and blends of frying oil containing varying amounts of polymers. 13 and 17 laboratories were included in the first and second IUPAC collaborative studies, respectively. Another collaborative study conducted by Inspectorate for Health Protection, Food Inspection Service, The Netherlands, included 13 laboratories. 6 heat-processed fat samples (3 pairs of split samples) containing 14-28% (w/w) of polymerized triglycerides were studied. The method was adopted by AOAC INTERNATIONAL as an IUPAC-AOCS-AOAC method.
KW - analytical methods
KW - animal fat
KW - liquid chromatography
KW - plant oils
KW - polymerization
KW - triacylglycerols
KW - analytical techniques
KW - triglycerides
KW - vegetable oils
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening procedure for organochlorine and organophosphorus pesticide residues in eggs using a solid-phase extraction cleanup and gas chromatographic detection.
AU - Schenck, F. J.
AU - Wagner, R.
AU - Hennessey, M. K.
AU - Okrasinski, J. L., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 4
SP - 1036
EP - 1040
SN - 1060-3271
AD - Schenck, F. J.: US Food and Drug Administration, Baltimore District, 900 Madison Ave., Baltimore, MD 21201, USA.
N1 - Accession Number: 19950501575. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 57-74-9, 12789-03-6, 470-90-6, 2921-88-2, 50-29-3, 333-41-5, 60-57-1, 72-20-8, 608-73-1, 76-44-8, 58-89-9, 121-75-5, 950-37-8, 298-00-0, 41198-08-7. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Poultry; Animal Nutrition; Human Nutrition; Agricultural Entomology
N2 - A solid-phase extraction (SPE) screening procedure for the isolation and gas chromatographic (GC) determination of organochlorine (OC) and organophosphorus (OP) pesticide residues in eggs is described. Eggs are extracted with acetonitrile. The extract is subjected to a cleanup on tandem C18 and Florisil SPE columns. OC and OP pesticide residues are determined by GC with electron capture and flame photometric detection, respectively. Because the injected extracts are free from matric interferences, the amount of residue present is easy to calculate. The average recoveries of 9 spiked OC pesticide residues (0.01-1.0 ppm) ranged from 80.9 to 91.1%. The average recoveries of 7 spiked OP pesticide residues (0.01-0.50 ppm) ranged from 80.3 to 89.5%. The SPE method results in a 90% reduction in organic solvent consumption and an 85% reduction in hazardous waste production compared with the AOAC methodology.
KW - agricultural entomology
KW - analysis
KW - analytical methods
KW - chlordane
KW - chlorfenvinphos
KW - chlorpyrifos
KW - DDT
KW - diazinon
KW - dieldrin
KW - eggs
KW - endrin
KW - gas chromatography
KW - HCH
KW - heptachlor
KW - insecticide residues
KW - insecticides
KW - lindane
KW - malathion
KW - methidathion
KW - nontarget effects
KW - organochlorine compounds
KW - organochlorine insecticides
KW - organophosphorus compounds
KW - organophosphorus insecticides
KW - parathion-methyl
KW - pesticide residues
KW - pesticides
KW - profenofos
KW - residues
KW - techniques
KW - analytical techniques
KW - benzene hexachloride
KW - BHC
KW - chlorpyrifos-ethyl
KW - dicophane
KW - methyl parathion
KW - nonachlor
KW - organic chlorine compounds
KW - organic phosphorus compounds
KW - organophosphates
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of multiple sulfonamide residues in bovine milk: collaborative study.
AU - Smedley, M. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 5
SP - 1112
EP - 1122
SN - 1060-3271
AD - Smedley, M. D.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Division of Residue Chemistry, Beltsville, MD 20705, USA.
N1 - Accession Number: 19950400944. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 122-11-2, 57-68-1, 127-79-7, 59-40-5. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A collaborative study involving 8 laboratories was conducted on the determination of 8 sulphonamide residues in raw milk using a liquid chromatographic (LC) method. The sulphonamides are extracted with chloroform-acetone, the organic phase is evaporated, the residues are dissolved in an aqueous potassium phosphate solution, and the fatty residues are removed by washing with hexane. The aqueous layer is collected, filtered, and injected onto an LC system, and the analyte is detected by UV absorption at 265 nm. To quantitate all 8 sulphonamides isocratically, 2 chromatographic conditions are required: 12% methanol in the mobile phase for 5 sulphonamides, and 30% methanol in the mobile phase for 4 sulphonamides. Sulphamethazine (SMZ), the most widely used sulphonamide, is detected by both systems. Collaborators were instructed to analyse 3 replicates each of control milk and control milk fortified at 3 levels. They were also provided with 20 blind incurred samples (10 samples in duplicate) to analyse. For 10 p.p.b. fortified milk, the average interlaboratory recovery for the 8 sulphonamides ranged from 56.2% for sulphaquinoxaline (SQX) to 82.7% for SMZ in the 12% methanol mobile phase (SMZ12). Also at this level, Sr ranged from 3.2 for SQX to 8.9 for SMZ12, and SR ranged from 6.9 for sulphadimethoxine to 17.2 for SMZ in the 30% methanol system (SMZ30). At 10 p.p.b., RSDr and RSDR ranged from 5.7% for SQX to 10.8% for SMZ12, and 10.1% for sulphamerazine to 20.9% for SMZ30, respectively. These results demonstrate that the method is suitable for the determination of the 8 sulphonamide residues in milk at 10 p.p.b. However, the identification of positives by this procedure needs additional confirmation by procedures comparable with the specificity achievable by liquid or gas chromatography combined with MS.
KW - analytical methods
KW - chromatography
KW - cows
KW - detection
KW - determination
KW - drug residues
KW - drugs
KW - liquid chromatography
KW - milk
KW - milk hygiene
KW - residues
KW - sulfadimethoxine
KW - sulfadimidine
KW - sulfamerazine
KW - sulfaquinoxaline
KW - sulfonamides
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - sulfamethazine
KW - sulphadimethoxine
KW - sulphadimidine
KW - sulphamerazine
KW - sulphaquinoxaline
KW - sulphonamides
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400944&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alternative sieving method for extraction of light filth from cheeses: collaborative study.
AU - Nakashima, M. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 5
SP - 1153
EP - 1156
SN - 1060-3271
AD - Nakashima, M. J.: U.S. Food and Drug Administration, Division of Microbiology, Washington, DC 20204, USA.
N1 - Accession Number: 19950400981. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A collaborative study was conducted on an alternative sieving method for the extraction of light filth from cheeses. The alternative method was developed that is applicable to a broad variety of cheeses. A 225-g test portion is dispersed in a solution of 5.7% HCl, lgepal CO-730, and lgepal DM-710. Digested cheese is wet-sieved on a No. 230 sieve. The residue is treated with Tergitol Anionic 4, transferred to 1% sodium lauryl sulphate solution, heated, and maintained at 65-75°C for 10 min. The residue is washed with these 2 surfactants a maximum of 4 times until it is reduced to an amount that is filterable. The residue is filtered and the filter papers are examined microscopically at a magnification of about 30×. Average recoveries by 9 collaborators for 3 spike levels of rat hairs (5, 10 and 15) were 80, 68 and 81%, respectively; for insect fragments (5, 15 and 30) recoveries were 97, 90 and 92%, respectively. The alternative sieving method for extraction of light filth from cheeses has been adopted first action by AOAC International.
KW - cheeses
KW - contaminants
KW - cows
KW - foreign bodies
KW - methodology
KW - removal
KW - sieving
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - methods
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400981&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of gas chromatography/matrix isolation/Fourier transform infrared spectroscopy to the identification of pyrrolizidine alkaloids from comfrey root (Symphytum officinale L.).
AU - Mossoba, M. M.
AU - Lin, H. S.
AU - Andrzejewski, D.
AU - Sphon, J. A.
AU - Betz, J. M.
AU - Miller, L. J.
AU - Eppley, R. M.
AU - Trucksess, M. W.
AU - Page, S. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 5
SP - 1167
EP - 1174
SN - 1060-3271
AD - Mossoba, M. M.: U.S. Food and Drug Administration, Division of General Scientific Support, Washington, DC 20204, USA.
N1 - Accession Number: 19960304560. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Horticultural Science
N2 - A method to identify pyrrolizidine alkaloids (extracted from S. officinale roots grown in Washington State, USA) is presented which uses gas chromatography/matrix isolation/Fourier transform infrared (GC/MI/FTIR) spectroscopy. Infrared spectral bands observed in the fingerprint region were unique even for closely related structures. The identities of the 4 major components, intermedine, lycopsamine, 7-acetylintermedine and 7-acetyllycopsamine, were confirmed by comparison with standards and GC-MS. The infrared spectra observed for the components of the root extract were consistent with known structures of specific alkaloids. The identities of the minor components, symphytine and its isomers symlandine and/or symviridine, were not confirmed.
KW - analytical methods
KW - chemical structure
KW - gas chromatography
KW - infrared spectroscopy
KW - medicinal plants
KW - plant composition
KW - plant extracts
KW - pyrrolizidine alkaloids
KW - roots
KW - USA
KW - Washington
KW - Boraginaceae
KW - Symphytum officinale
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Symphytum
KW - Boraginaceae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - analytical techniques
KW - Boraginales
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - United States of America
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of cholesterol by p-nitrobenzoate derivatization and liquid chromatography.
AU - Hamill, T. W.
AU - Soliman, A. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 5
SP - 1190
EP - 1196
SN - 1060-3271
AD - Hamill, T. W.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, HFR-SE680, 60 Eighth St NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 19950400982. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 57-88-5. Subject Subsets: Dairy Science; Human Nutrition
N2 - The method involves direct saponification and formation of the sterol p-nitrobenzoate (PNB) derivatives or lipid extraction with methylene chloride and isopropyl alcohol, saponification, fatty acid methylation, and formation of the sterol PNB derivatives. The sterol PNB derivatives are separated on a C8 column with a mobile phase of acetonitrile-hexane-water (250 + 30 + 3) and quantitated by UV detection at 280 nm. The limit of detection for cholesterol is 2 ng. The response was linear over a range of 4 to 250 ng (r = 0.999). Assays of dried egg (NIST SRM 1845 and 1563) by this method gave results that were closer to the certified values than were results obtained by the AOAC GC method. Reproducibility was evaluated by using foods containing low, medium, and high levels of cholesterol. The CV ranged from 1.8 to 6.7%. Studies on a wide variety of food products (using lipid extraction and saponification-methylation) gave a mean recovery of 87.5±10.1%. Direct saponification of poultry and milk products gave a mean recovery of 101.3±15.8%. Peak purity was determined by diode array spectrophotometry.
KW - analytical methods
KW - cheeses
KW - cholesterol
KW - chromatography
KW - Cottage cheese
KW - cows
KW - determination
KW - egg products
KW - eggs
KW - evaporated milk
KW - fats
KW - food products
KW - foods
KW - infant formulae
KW - liquid chromatography
KW - milk fat
KW - milk products
KW - skim milk
KW - sterols
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - butterfat
KW - dairy products
KW - infant formula
KW - infant formulas
KW - Milk and Dairy Produce (QQ010)
KW - Eggs and Egg Products (QQ040)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950400982&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Radionuclides in domestic and imported foods in the United States, 1987-1992.
AU - Cunningham, W. C.
AU - Anderson, D. L.
AU - Baratta, E. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 6
SP - 1422
EP - 1427
SN - 1060-3271
AD - Cunningham, W. C.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Elemental Research Branch (HFS-338), Washington, DC 20204, USA.
N1 - Accession Number: 19960400259. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Findings from the U.S. Food and Drug Administration Radionuclides in Foods programme are summarized for foods collected between October 1, 1986, and September 30, 1992. Concentrations of radionuclide activity in the Total Diet Study and reactor-survey foods were in Range I or low in Range II of the surveillance and control recommendations of the Federal Radiation Council; no control actions were suggested. Dietary intake of 90Sr continued the general decline observed since 1961. Approximately 2600 test portions of imported foods were analysed for contamination associated with the Chernobyl nuclear accident. Concentrations of radionuclide activity were below limits of detection for the vast majority of the imported food test portions but were above the levels of concern for 23 portions. Since 1986, the fraction of imported food test portions having measurable amounts of contamination has steadily declined, as have the average concentrations of radionuclide activity; however, contamination is still occasionally found. Continued monitoring of both domestic and imported foods is planned.
KW - food contamination
KW - food safety
KW - foods
KW - milk
KW - radiation
KW - radioactivity
KW - radionuclides
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chernobyl accident
KW - food contaminants
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multifunctional column coupled with liquid chromatography for determination of aflatoxins B1, B2, G1, and G2 in corn, almonds, Brazil nuts, peanuts, and pistachio nuts: collaborative study.
AU - Trucksess, M. W.
AU - Stack, M. E.
AU - Nesheim, S.
AU - Albert, R. H.
AU - Romer, T. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 6
SP - 1512
EP - 1521
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 19951200578. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Horticultural Science; Medical & Veterinary Mycology; Postharvest Research; Animal Nutrition; Human Nutrition; Maize
N2 - An AOAC/IUPAC collaborative study was conducted to evaluate the effectiveness of a multifunctional column for the determination of aflatoxins. The test portion is extracted with acetonitrile-water (9 + 1), the extract is filtered, and the filtrate is passed through the column. The aflatoxins in the eluate are determined by reverse-phase liquid chromatography after derivatization with trifluoroacetic acid. Naturally contaminated maize, almonds, Brazil nuts, groundnuts and pistachio nuts spiked with total aflatoxins at 5, 10, 20 and 30 ng/g were sent to 12 collaborators in the USA, Denmark, France, Japan and Switzerland. 11 collaborators completed the study. Mean recoveries of total aflatoxins for each spike level for the various commodities (excluding Brazil nuts at 5 ng/g) were 93, 97, 95 and 95%, respectively; the repeatability relative standard deviation (RSDr) ranged from 6.0 to 23.2% and the reproducibility relative standard deviation (RSDR) ranged from 12.0 to 69.4%. The multifunctional column coupled with a liquid chromatographic method for determination of aflatoxins in maize, almonds, Brazil nuts, groundnuts and pistachio nuts was adopted as a first action by AOAC International.
KW - aflatoxins
KW - almonds
KW - analytical methods
KW - biodeterioration
KW - Brazil nuts
KW - contamination
KW - determination
KW - estimation
KW - foods
KW - groundnuts
KW - liquid chromatography
KW - maize
KW - mycotoxins
KW - nuts
KW - pistachios
KW - techniques
KW - Arachis hypogaea
KW - Bertholletia excelsa
KW - Pistacia
KW - Pistacia vera
KW - Prunus dulcis
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Bertholletia
KW - Lecythidaceae
KW - Lecythidales
KW - Theales
KW - Anacardiaceae
KW - Sapindales
KW - Pistacia
KW - Prunus
KW - Rosaceae
KW - Rosales
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - analytical techniques
KW - corn
KW - fungal toxins
KW - peanuts
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Full scan confirmation of tetrahydrophthalimide in whole milk using gas chromatography/ion trap mass spectrometry.
AU - Chichila, T. M. P.
AU - Erney, D. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 6
SP - 1574
EP - 1580
SN - 1060-3271
AD - Chichila, T. M. P.: U. S. Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, 1560 East Jefferson Ave, Detroit, MI 48207, USA.
N1 - Accession Number: 19960400261. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science
N2 - The determination of tetrahydrophthalimide (THPI) in whole milk extracts by GC/ion trap MS (GC/ITMS) in the full-scan, electron impact (EI) mode is presented in this paper. THPI is first isolated from whole milk by a procedure including protein precipitation, liquid-liquid partitioning and 2 solid-phase extraction (SPE) cleanup steps. GC/ITMS in the EI mode is used for the determinative step. The average recovery of THPI at fortification levels ranging from 5 to 54 p.p.b. was 85.6% (n = 16, coefficient of variation = 9.13%). Full-scan mass spectral confirmation of THPI in milk extracts was obtained at the 5 p.p.b. fortification level. The limit of detection was estimated to be 0.5 p.p.b. Chemical ionization was also used for THPI determination in whole milk extracts. The simultaneous isolation and determination of captan and captafol in whole milk are also discussed.
KW - analytical methods
KW - chromatography
KW - contamination
KW - degradation
KW - detection
KW - determination
KW - dicarboximide fungicides
KW - fungicides
KW - gas chromatography
KW - mass spectrometry
KW - milk
KW - milk hygiene
KW - pesticide residues
KW - pesticides
KW - products
KW - residues
KW - analytical techniques
KW - fungistats
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960400261&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of a one-day procedure for recovery of Salmonella from milk powders.
AU - Hammack, T. S.
AU - Andrews, W. H.
AU - Amaguana, R. M.
AU - June, G. A.
AU - Sherrod, P. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1994///
VL - 77
IS - 6
SP - 1681
EP - 1684
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19960400262. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A rapid procedure for enumerating Salmonella in dried milk was evaluated. Dry whole milk and instant dry skim milk were rehydrated, artificially inoculated with various amounts of Salmonella, and stomached. Test portions were then treated with Tween 80 and pancreatic trypsin, and incubated for 1 h at 30°C. The incubated test portions were centrifuged at 10 000 ×g for 15 min at 5°C, and the resuspended pellets were plated on xylose lysine desoxycholate agar. The effectiveness of the procedure was expressed in terms of percentage recovery of the inoculum. The procedure, which was evaluated in 76 trials using 7 Salmonella serovars, recovered ≤73% of the inoculum for half of the trails conducted. Its effectiveness was dependent on the serovar, level of inoculation and type of dried milk used.
KW - bacterial count
KW - contamination
KW - detection
KW - dried milk
KW - dried skim milk
KW - milk products
KW - serotypes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - dairy products
KW - milk powder
KW - nonfat dry milk
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sizing up granulomas.
AU - Secor, W. E.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1994///
VL - 78
IS - 3
SP - 336
EP - 339
SN - 0014-4894
AD - Secor, W. E.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway North East, MS-F13, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19940805561. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 15 ref. Subject Subsets: Helminthology
N2 - A brief review is given of aspects of schistosome granuloma research presented at a symposium during the joint meeting of the American Society of Tropical Medicine and Hygiene and the American Society of Parasitologists (October 31-November 4, 1993, Atlanta, GA, USA). Most attention was paid to the role of cytokines (interleukins, tumour necrosis factor, and interferon).
KW - cytokines
KW - granuloma
KW - helminths
KW - human diseases
KW - immunopathology
KW - parasites
KW - Digenea
KW - Schistosoma
KW - Schistosomatidae
KW - Trematoda
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - immunopathogenesis
KW - parasitic worms
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940805561&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasmodium ovale: observations on the parasite development in Saimiri monkey hepatocytes in vivo and in vitro in contrast with its inability to induce parasitaemia.
AU - Millet, P.
AU - Nelson, C.
AU - Galland, G. G.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Richardson, B. B.
AU - Collins, W. E.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1994///
VL - 78
IS - 4
SP - 394
EP - 399
SN - 0014-4894
AD - Millet, P.: Division of Parasitic Diseases, National Center for Infectious Diseases, Animal Resources Branch, Scientific Resources Program, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950801675. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Protozoology
N2 - Exoerythrocytic stages of Plasmodium ovale were cultured in vitro by inoculating primary cultures of hepatocytes from Saimiri sciureus boliviensis with sporozoites. Morphology and size of the liver stages were similar to previous in vivo descriptions in humans and chimpanzees. Saimiri monkeys did not develop parasitaemia after repeated inoculations with P. ovale sporozoites. However, liver-stage parasites were observed in liver biopsies performed 7 days after sporozoite inoculation. Together with observations on other parasite development, these results showed that host specificity for many malaria parasites occurs at the blood-stage level. Lack of host specificity of primary malaria parasite species for the liver forms the basis for the close relationship existing between human and nonhuman primate malaria species.
KW - development
KW - experimental infections
KW - host parasite relationships
KW - host specificity
KW - human diseases
KW - in vitro
KW - laboratory animals
KW - liver cells
KW - parasitaemia
KW - parasites
KW - Apicomplexa
KW - Cebidae
KW - Plasmodiidae
KW - Plasmodium ovale
KW - Primates
KW - protozoa
KW - Saimiri sciureus
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - Saimiri
KW - Cebidae
KW - hepatocytes
KW - parasite host relationships
KW - parasitemia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950801675&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro cultivation of exoerythrocytic stages of the simian malaria parasites Plasmodium fieldi and Plasmodium simiovale in rhesus monkey hepatocytes.
AU - Millet, P.
AU - Anderson, P.
AU - Collins, W. E.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1994///
VL - 80
IS - 3
SP - 384
EP - 388
SN - 0022-3395
AD - Millet, P.: Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19940804557. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Protozoology
N2 - Exoerythrocytic stage parasites of Plasmodium fieldi and P. simiovale, 2 simian malaria parasites related to the human malaria parasite Plasmodium ovale, were cultured in vitro by inoculating primary cultures of hepatocytes from rhesus monkeys (Macaca mulatta) with sporozoites. Less than 1% of sporozoites developed into schizonts for either species. Structure and size of the liver stages in both species were similar to previous in vivo descriptions, and the time required for in vitro maturation correlated well with the prepatent periods described for each species. Such monkey models could be very useful in conducting scientific investigations on the pre-erythrocytic stages of P. ovale-like malaria parasites.
KW - culture techniques
KW - developmental stages
KW - liver cells
KW - parasites
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium fieldi
KW - Plasmodium simiovale
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - growth phase
KW - hepatocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19940804557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Latrodectus mactans (black widow spider) envenomation: an unusual cause for abdominal pain in pregnancy.
AU - Scalzone, J. M.
AU - Wells, S. L.
JO - Obstetrics and Gynecology (New York)
JF - Obstetrics and Gynecology (New York)
Y1 - 1994///
VL - 83
IS - 5, Part 2
SP - 830
EP - 831
SN - 0029-7844
AD - Scalzone, J. M.: Shiprock Public Health Service Indian Hospital, Navajo Area, Indian Health Service, Shiprock, NM, USA.
N1 - Accession Number: 19950500211. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The case report of a pregnant 30-year-old Native American woman who suffered acute abdominal pain (at 30 weeks' gestation) caused by a bite from L. mactans is presented from New Mexico, USA.
KW - arachnidism
KW - bites
KW - case reports
KW - envenomation
KW - pregnancy
KW - spider bites
KW - women
KW - New Mexico
KW - USA
KW - Arachnida
KW - Araneae
KW - Latrodectus mactans
KW - man
KW - Theridiidae
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Arachnida
KW - Latrodectus
KW - Theridiidae
KW - Araneae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - black widow spider
KW - gestation
KW - spiders
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950500211&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic neurological sequelae to organophosphate pesticide poisoning.
AU - Steenland, K.
AU - Jenkins, B.
AU - Ames, R. G.
AU - O'Malley, M.
AU - Chrislip, D.
AU - Russo, J.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994///
VL - 84
IS - 5
SP - 731
EP - 736
SN - 0090-0036
AD - Steenland, K.: National Institute for Occupational Safety and Health, R-13, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19950501614. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 2921-88-2, 333-41-5, 60-51-5, 7786-34-7, 2310-17-0. Subject Subsets: Medical & Veterinary Entomology; Public Health; Agricultural Entomology
N2 - This work was undertaken to determine whether there are any chronic neurological sequelae to acute organophosphate (OP) pesticide poisoning. California surveillance data were used in a study of neurological function among 128 men poisoned by OP pesticides (e.g. phosalone, mevinphos, diazinon, chlorpyrifos, dimethoate and demeton-methyl) in California, USA, from 1982 to 1990 and 90 referents. Tests included a neurological physical examination, 5 nerve conduction tests, 2 vibrotactile sensitivity tests, 10 neurobehavioural tests, and 1 postural sway test. After correcting for confounding, the poisoned group performed significantly worse than the referent group on 2 neurobehavioural tests (sustained visual attention and mood scales). When the data were restricted to men with documented cholinesterase inhibition (n = 83) or to men who had been hospitalized (n = 36), the poisoned subjects also showed significantly worse vibrotactile sensitivity of finger and toe. Significant trends of increased impairment were found with increased days of disability on a wide spectrum of tests of both central and peripheral nerve function. While these findings are limited by low response rates and by small sample sizes for specific pesticides, this study was based on a large surveillance database and is the largest study to date of the chronic effects of OP pesticide poisoning. The evidence of some long-term effects of poisoning is consistent with 2 prior studies.
KW - agricultural entomology
KW - behaviour
KW - chlorpyrifos
KW - diazinon
KW - dimethoate
KW - effects
KW - insecticides
KW - mevinphos
KW - nervous system diseases
KW - neurotoxicity
KW - nontarget effects
KW - occupational hazards
KW - organophosphate insecticides
KW - organophosphorus compounds
KW - organophosphorus insecticides
KW - organophosphorus pesticides
KW - pesticides
KW - phosalone
KW - poisoning
KW - toxicology
KW - California
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - chlorpyrifos-ethyl
KW - demeton-methyl
KW - neuropathy
KW - organic phosphorus compounds
KW - organophosphates
KW - toxicosis
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Human Health and the Environment (VV500)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950501614&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Foodborne bacterial infections in individuals with the human immunodeficiency virus.
AU - Altekruse, S.
AU - Hyman, F.
AU - Klontz, K.
AU - Timbo, B.
AU - Tollefson, L.
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 1994///
VL - 87
IS - 2
SP - 169
EP - 173
SN - 0038-4348
AD - Altekruse, S.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Market Studies, Epidemiology Branch, HFS-728, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 19942006275. Publication Type: Journal Article. Language: English.
KW - Bacteraemia
KW - Food contamination
KW - Gastroenteritis
KW - HIV infections
KW - Meningitis
KW - Opportunistic infections
KW - Bacteria
KW - Campylobacter jejuni
KW - Listeria monocytogenes
KW - Salmonella
KW - Vibrio
KW - prokaryotes
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Vibrionaceae
KW - Vibrionales
KW - bacteremia
KW - bacterium
KW - food contaminants
KW - human immunodeficiency virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19942006275&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health nutrition: a historical perspective.
AU - Egan, M. C.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1994///
VL - 94
IS - 3
SP - 298
EP - 304
SN - 0002-8223
AD - Egan, M. C.: Bureau of Maternal and Child Health, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD 20857, USA.
N1 - Accession Number: 19941410855. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition
KW - nutrition
KW - public health
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941410855&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition: a cofactor in HIV disease.
AU - Timbo, B. B.
AU - Tollefson, L.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1994///
VL - 94
IS - 9
SP - 1018
EP - 1022
SN - 0002-8223
AD - Timbo, B. B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951400253. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition
N2 - The relations among nutritional state, infectious disease and the immune system suggest that nutrition may be a cofactor in human immunodeficiency virus (HIV) progression. Nutrition as a cofactor in HIV disease was examined by reviewing literature on the interactions of nutrition, infectious disease processes and immune system dysfunction. Studies demonstrate that poor nutritional state and infection affect the immune system and interact with each other. This relation leads to the development of opportunistic infections and malignancies, which may result in a diagnosis of acquired immunodeficiency syndrome. Moreover, evidence indicates that nutritional state may play a role in HIV disease progression.
KW - human immunodeficiency viruses
KW - immune system
KW - infectious diseases
KW - nutritional state
KW - reviews
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - human immunodeficiency virus
KW - nutritional status
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951400253&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of pulsed-field gel electrophoresis to the epidemiological characterization of Staphylococcus intermedius implicated in a food-related outbreak.
AU - Khambaty, F. M.
AU - Bennett, R. W.
AU - Shah, D. B.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 1994///
VL - 113
IS - 1
SP - 75
EP - 81
SN - 0950-2688
AD - Khambaty, F. M.: Division of Microbiological Studies, U.S. Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19952006020. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - An outbreak of food intoxication involving over 265 cases in western USA occurred in October 1991. Staphylococcus intermedius was implicated as the aetiological agent. Representative outbreak isolates (5 clinical and 10 from foods) produced type A enterotoxin. DNA fragments generated by 4 restriction endonucleases and analysed by pulsed-field gel electrophoresis (PFGE) provided definitive evidence that all isolates from 9 different counties in California and Nevada were derived from a single strain. The PFGE pattern of these outbreak isolates was distinct from those of a heterogeneous collection of 7 S. intermedius strains of veterinary origin and 5 unrelated S. aureus laboratory strains. The data show a significant PFGE pattern heterogeneity not only among members of different Staphylococcus species but also within members of the same species and even the same enterotoxin type. The results indicate that PFGE is a valuable strain-specific discriminator for the epidemiological characterization of S. intermedius. These findings suggest that the presence of S. intermedius and other species such as S. hyicus in food should be reason for concern.
KW - diagnosis
KW - epidemiology
KW - food contamination
KW - food poisoning
KW - human diseases
KW - infections
KW - outbreaks
KW - pulsed field electrophoresis
KW - California
KW - Nevada
KW - North America
KW - USA
KW - man
KW - Staphylococcus intermedius
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - bacterium
KW - food contaminants
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006020&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of selenium in food supplements by differential-pulse cathodic stripping voltammetry in the presence of added copper.
AU - Holak, W.
AU - Specchio, J. J.
JO - Analyst
JF - Analyst
Y1 - 1994///
VL - 119
IS - 10
SP - 2179
EP - 2182
SN - 0003-2654
AD - Holak, W.: US Food and Drug Administration, 850 Third Avenue, Brooklyn, New York 11232, USA.
N1 - Accession Number: 19951410521. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 7440-50-8, 7782-49-2. Subject Subsets: Human Nutrition
N2 - Selenium was estimated by cathodic stripping voltammetry in a 1 mol/litre HCl solution containing added CuII. In this medium, Se was preconcentrated on the hanging mercury drop electrode and stripped cathodically in differential-pulse mode. After a deposition period of 1 min, Se 0.2 ng/ml could be detected. The method was applied to the analysis of food supplements. Total Se was estimated after digestion of the sample with HNO3-HClO4 and reduction to the electroactive SeIV by heating with HCl. Inorganic Se (i.e., selenite and selenate) was similarly estimated after extraction with dilute sodium hydroxide solution and clean-up on activated carbon. Representative over-the-counter preparations were analysed.
KW - analytical methods
KW - copper
KW - food supplements
KW - selenium
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951410521&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Marginal zinc status does not exacerbate pancreatic carcinogenesis associated with dietary soybean trypsin inhibitor concentrate in rats.
AU - Ellwood, K. C.
AU - Roebuck, B. D.
AU - Hathcock, J. N.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1994///
VL - 124
IS - 6
SP - 894
EP - 900
SN - 0022-3166
AD - Ellwood, K. C.: Division of Science and Applied Technology, Office of Special Nutritionals, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19941409410. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7440-66-6. Subject Subsets: Human Nutrition; Soyabeans
N2 - Male Sprague-Dawley rats (14 days old) were given a single injection of saline or azaserine and were weaned (21 days) to diets with adequate (30 µg/g) or low (9 µg/g) zinc, without or with active trypsin inhibitor (1.0 g/100 g) in the form of soyabean trypsin inhibitor concentrate. Experimental diets were fed for 14 weeks. Regardless of dietary Zn status, diets with soyabean trypsin inhibitor concentrate caused hyperplasia and/or hypertrophy of the pancreas. Pancreatic Zn content was not different among groups. Low dietary Zn did not affect total body growth rate or serum Zn concentration. Tibia Zn was also used as an indicator of Zn status. Tibia Zn concentration was lower in rats fed on diets low in Zn relative to adequate Zn diets. Azaserine-induced acidophilic foci were larger and more numerous when soyabean trypsin inhibitor concentrate was present in the diet regardless of dietary Zn level. Thus, low Zn does not exacerbate the soyabean trypsin inhibitor concentrate effects that promote pancreatic cancer.
KW - carcinogenesis
KW - deficiency
KW - pancreas
KW - soyabeans
KW - trypsin inhibitors
KW - zinc
KW - Glycine (Fabaceae)
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19941409410&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Blood and sporozoite stage-specific small subunit ribosomal RNA-encoding genes of the human malaria parasite Plasmodium vivax.
AU - Qari, S. H.
AU - Goldman, I. F.
AU - Pieniazek, N. J.
AU - Collins, W. E.
AU - Lal, A. A.
JO - Gene
JF - Gene
Y1 - 1994///
VL - 150
IS - 1
SP - 43
EP - 49
SN - 0378-1119
AD - Qari, S. H.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19960800200. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology
N2 - The sporozoite stage-specific C and blood stage-specific A forms of the SSUrDNA gene from Plasmodium vivax are characterized. The sequences were aligned and compared with SSUrDNA sequences of P. falciparum and P. malariae to identify the regions with potential for diagnostic probes. The comparison revealed the presence of 7 conserved regions (≥ 90% similarity), 4 highly variable regions (< 60% similarity) and 3 semiconserved regions. The analysis also revealed that the A and C genes of P. vivax share more similarity with each other, compared to the A and C genes of P. falciparum. Comparison of the SSUrDNA of human (P. vivax, P. falciparum and P. malariae), monkey (P. cynomolgi) and rodent (P. berghei) malaria parasites revealed that the A genes share more similarity with each other than the C genes share with each other.
KW - developmental stages
KW - DNA probes
KW - genes
KW - molecular genetics
KW - nucleotide sequences
KW - parasites
KW - ribosomal RNA
KW - RNA
KW - Plasmodium
KW - Plasmodium berghei
KW - Plasmodium cynomolgi
KW - Plasmodium falciparum
KW - Plasmodium malariae
KW - Plasmodium vivax
KW - protozoa
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - biochemical genetics
KW - DNA sequences
KW - growth phase
KW - ribonucleic acid
KW - rRNA
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960800200&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of binding of monoclonal antibody to a malarial peptide by surface plasmon resonance biosensor and integrated rate equations.
AU - Wohlhueter, R. M.
AU - Parekh, K.
AU - Udhayakumar, V.
AU - Fang, S.
AU - Lal, A. A.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1994///
VL - 153
IS - 1
SP - 181
EP - 189
SN - 0022-1767
AD - Wohlhueter, R. M.: Biotechnology Core Facility Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950803676. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Using biosensor technology and integrated rate equations, procedures to determine the kinetic parameters and equilibrium affinity constant of antigen-antibody (Ag-Ab) interactions were developed. The Ag used in these studies was a peptide that represents the major B cell epitope of the circumsporozoite protein of Plasmodium falciparum, a promising malaria vaccine candidate Ag. Measurements of association and dissociation rate constants of this peptide with the MAb 2A10 were determined by fitting integrated rate equations to binding data obtained with a BIAcore surface plasmon-resonance biosensor. It was examined whether accurate estimates of initial velocity and final equilibrium levels of binding of Ab to peptides can be obtained using these methods, and whether kinetic rates and equilibrium constants obtained with systematic variation of the experimental parameters conform to a simple bimolecular model of binding. It was found that initial velocity was approximately first order with respect to Ab concentration. When a series of 4 sensor cells with different peptides loads was used, however, it was found that the initial velocity of binding appeared to be nearly independent of peptide concentration. Equilibrium analyses yielded dissociation constants of approximately 3 × 10-7M. Integrated rate treatment of biosensor data supports a critical examination of the assumptions on which the binding models are based and suggests a need to refine such models. Nevertheless, it provides a powerful quantitative tool for assessing the Ag-Ab binding reaction.
KW - antigens
KW - circumsporozoite protein
KW - malaria
KW - mathematical models
KW - monoclonal antibodies
KW - parasites
KW - Apicomplexa
KW - Plasmodiidae
KW - Plasmodium falciparum
KW - protozoa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - Plasmodiidae
KW - antigenicity
KW - immunogens
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950803676&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emerging infectious diseases in the United States, 1993.
AU - Berkelman, R. L.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1994///
VL - 170
IS - 2
SP - 272
EP - 277
SN - 0022-1899
AD - Berkelman, R. L.: Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19952001108. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - Three outbreaks of disease in the USA in 1993 caused by Escherichia coli O157:H7, Cryptosporidium organisms, and a previously unrecognized hantavirus clearly illustrate the increasing challenges posed by emerging infectious diseases. The largest USA outbreak of Esch. coli O157:H7 infection reported occurred as a result of contaminated hamburgers served at a fast-food restaurant chain. The largest recorded waterborne disease outbreak in USA history was due to contamination of a municipal water supply with cryptosporidia. In the southwestern USA, hantavirus was first recognized as the cause of a pulmonary syndrome with a mortality rate exceeding 50%. The detection of and response to these outbreaks document the need for a strong partnership between the clinical and public health sectors to prevent and control diseases. Health care reform in the USA provides an opportunity to address critical needs, such as improved surveillance and diagnosis, to ensure timely detection of and rapid response to newly emerging infectious diseases.
KW - cryptosporidiosis
KW - epidemiology
KW - human diseases
KW - infections
KW - infectious diseases
KW - outbreaks
KW - waterborne diseases
KW - North America
KW - USA
KW - Bunyaviridae
KW - Cryptosporidium
KW - Escherichia coli
KW - hantavirus
KW - man
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bunyaviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - communicable diseases
KW - E. coli
KW - O157:H7
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001108&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differential proliferative and interleukin-10 responses to fractionated filarial antigens: preferential recognition by patients with chronic lymphatic dysfunction.
AU - Dimock, K. A.
AU - Addiss, D. G.
AU - Eberhard, M. L.
AU - Lammie, P. J.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1994///
VL - 170
IS - 2
SP - 403
EP - 412
SN - 0022-1899
AD - Dimock, K. A.: Division of Parasitic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19952001115. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 130068-27-8. Subject Subsets: Tropical Diseases; Helminthology
N2 - To characterize filarial antigens that may be associated with the development of chronic lymphatic dysfunction in persons with lymphatic filariasis, T cell responsiveness to Brugia pahangi adult worm extracts and SDS-PAGE antigen fractions were examined among Haitians from an area in which Wuchereria bancrofti is endemic. Greater T cell proliferation and interleukin-10 (IL-10) production were observed in amicrofilaraemic patients with hydrocele or elephantiasis than in amicrofilaraemic or microfilaraemic asymptomatic persons. Antigen fractions that stimulated the highest proliferative responses (in the 25-49 kDa range) and IL-10 production were not identical. Further separation of an immunodominant 30- to 38-kDa fraction by ion exchange high-pressure liquid chromatography identified several subfractions, including a 32-kDa protein band, that elicited T cell responses from patients with elephantiasis or hydrocele. By immunoblot, these patients also had markedly greater humoral reactivity to parasite antigens of ~52, 43, 32, and 30 kDa.
KW - antigens
KW - filariasis
KW - helminths
KW - human diseases
KW - immune response
KW - interleukin 10
KW - lymphatic filariasis
KW - parasites
KW - T lymphocytes
KW - Caribbean
KW - Haiti
KW - Brugia pahangi
KW - man
KW - Wuchereria bancrofti
KW - Brugia
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Wuchereria
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - antigenicity
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - T cells
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952001115&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - T-helper cell epitopes on the E-glycoprotein of dengue 2 Jamaica virus.
AU - Roehrig, J. T.
AU - Risi, P. A.
AU - Brubaker, J. R.
AU - Hunt, A. R.
AU - Beaty, B. J.
AU - Trent, D. W.
AU - Mathews, J. H.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1994///
VL - 198
IS - 1
SP - 31
EP - 38
SN - 0042-6822
AD - Roehrig, J. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950507587. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - To identify T-helper (Th)-cell epitopes, 25 synthetic peptides, which included most of the 495-amino-acid sequence of the envelope (E)-glycoprotein of dengue 2 virus were analyzed. The peptides were analyzed in 3 mouse strains, BALB/c (H-2d), C57BL/6 (H-2b), and outbred NIH-Swiss, for their ability to elicit antibody or prime the Th-cell compartment following 2 inoculations in Freund's incomplete adjuvant. 16 peptides were able to elicit an antipeptide antibody response in 1 or more mouse strain. 11 antipeptide serum pools were able to bind to virus in ELISA. 15 peptides primed 1 or more haplotype for an in vitro antipeptide Th-cell response as measured by blastogenesis. Th-cell activation was generally confirmed by measurable in vitro production of interleukin (IL)-2/IL-4. 9 peptides which were positive for in vitro blastogenesis, 1-2, 35, 4-6, 79, 142, 208, 06, 16, and 17, elicited virus-reactive Th-cells in vitro in H-2d mice. 2 of these peptides (4-6 and 17) were able to prime virus-reactive Th-cells in H-2b mice. 9 peptides primed outbred mice in vivo for an antiviral antibody response significantly greater than that seen in animals primed with an irrelevant peptide. These results correlate with, and expand on, previous observations based on a smaller set of synthetic peptides derived from the E-glycoprotein of Murray Valley encephalitis virus and suggest that synthetic peptides can function as E-glycoprotein Th-cell epitopes. The similarity of results between 2 distantly related flaviviruses suggests that E-glycoprotein Th-cell epitopes are consistent in location and activity.
KW - antibodies
KW - arboviruses
KW - glycoproteins
KW - immune response
KW - laboratory animals
KW - viral proteins
KW - dengue 2 virus
KW - dengue virus
KW - mice
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arthropod-borne viruses
KW - immunity reactions
KW - immunological reactions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The envelope glycoproteins of dengue 1 and dengue 2 viruses grown in mosquito cells differ in their utilization of potential glycosylation sites.
AU - Johnson, A. J.
AU - Guirakhoo, F.
AU - Roehrig, J. T.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1994///
VL - 203
IS - 2
SP - 241
EP - 249
SN - 0042-6822
AD - Johnson, A. J.: Division of Vector-borne Infectious Diseases, National Center for Infectious Diseases, Centers for Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950508754. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The authors have previously isolated and characterized 2 dengue (DEN) 2 viruses mutant in their fusion-from-within (FFWI) phenotype in the Aedes albopictus cell line C6/36. Both viruses lost a potential glycosylation site (Asn-153) in the envelope (E) glycoprotein. To determine whether the change in FFWI phenotype was due to a change in E-glycoprotein glycosylation, the patterns of glycosylation on the E-glycoprotein of wild-type DEN 1 and DEN 2 viruses were characterized. The E-glycoproteins were isolated from purified virus grown in C6/36 cells, by use of high-performance size-exclusion chromatography. The tryptic maps of wild-type glycosylated and enzymatically (PNGase F) deglycosylated E-glycoproteins were compared by reverse-phase high-performance liquid chromatography. The DEN 1 virus E-glycoprotein was found to have 2 peaks in the tryptic map that exhibited shifts after deglycosylation, whereas the DEN 2 virus E-glycoprotein had only 1. Besides the potential glycosylation site at Asn-153, both DEN 1 and DEN 2 virus E-glycoproteins have another potential site located at Asn-67. Amino-terminal sequencing of the shifted peaks revealed that DEN 2 virus E-glycoprotein is glycosylated only at Asn-67; however, DEN 2 virus E-glycoprotein is glycosylated at both Asn-67 and Asn-153. These DEN virus serotypes are thus heterogeneous in their use of glycosylation sites. It was also determined by a lectin-binding assay that the attached carbohydrates for both viruses were likely to be of the high-mannose type.
KW - arboviruses
KW - cell lines
KW - glycoproteins
KW - infections
KW - viral proteins
KW - Aedes albopictus
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950508754&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Processing of Flavivirus structural glycoproteins: stable membrane insertion of premembrane requires the envelope signal peptide.
AU - Markoff, L.
AU - Chang, A.
AU - Falgout, B.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1994///
VL - 204
IS - 2
SP - 526
EP - 540
SN - 0042-6822
AD - Markoff, L.: Laboratory of Vector-borne Virus Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19950507855. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - membranes
KW - viral proteins
KW - dengue 4 virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - signal peptides
KW - structural proteins
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950507855&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Of worms, dogs, and human hosts: continuing challenges for veterinarians in prevention of human disease.
AU - Schantz, P. M.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1994///
VL - 204
IS - 7
SP - 1023
EP - 1028
SN - 0003-1488
AD - Schantz, P. M.: Division of Parasitic Diseases, National Center For Infectious Diseases, Centers For Disease Control and Prevention, Public Health Service, US Department of Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19942208093. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science; Helminthology
N2 - Topics discussed in this review are Toxocariasis, Echinococcosis and Taeniasis/Cysticercosis.
KW - Cysticercosis
KW - disease prevention
KW - dog diseases
KW - helminths
KW - parasites
KW - zoonoses
KW - dogs
KW - Echinococcus granulosus
KW - Echinococcus multilocularis
KW - Taenia solium
KW - Toxocara
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Echinococcus
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - Taenia
KW - Ascarididae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - Ascaridida
KW - nematodes
KW - parasitic worms
KW - pork tapeworm
KW - Secernentea
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pancreatic islet cells in preobese yellow Avy/-mice: relation to adult hyperinsulinemia and obesity.
AU - Warbritton, A.
AU - Gill, A. M.
AU - Yen, T. T.
AU - Bucci, T.
AU - Wolff, G. L.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1994///
VL - 206
IS - 2
SP - 145
EP - 151
SN - 0037-9727
AD - Warbritton, A.: Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951401650. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9004-10-8. Subject Subsets: Human Nutrition
KW - body weight
KW - hyperinsulinaemia
KW - insulin
KW - obesity
KW - pancreas islets
KW - resistance
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fatness
KW - hyperinsulinemia
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectious disease surveillance: A crumbling foundation.
AU - Berkelman, R. L.
AU - Bryan, R. T.
AU - Osterholm, M. T.
AU - Duc, J. W. le
AU - Hughes, J. M.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1994///
VL - 264
IS - 5157
SP - 368
EP - 370
SN - 0036-8075
AD - Berkelman, R. L.: National Center for Infectious Diseases, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19952008351. Publication Type: Journal Article. Language: English. Number of References: 18 ref.
N2 - A policy forum.
KW - human diseases
KW - infectious diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952008351&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pertussis vaccines: a progress report.
AU - Rabinovich, R.
AU - Robbins, A.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1994///
VL - 271
IS - 1
SP - 68
EP - 69
SN - 0098-7484
AD - Rabinovich, R.: National Vaccine Program, US Public Health Service, US Department of Health and Human Services, 200 Independence Avenue SW, Washington DC 20201, USA.
N1 - Accession Number: 19952006914. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Public Health
KW - human diseases
KW - immunization
KW - pertussis
KW - reviews
KW - vaccine development
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune sensitization
KW - whooping cough
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Confusion on malaria prophylaxis.
AU - Lobel, H. O.
AU - Keystone, J. S.
T2 - Lancet (British edition)
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1994///
VL - 343
IS - 8890
SP - 183
EP - 183
SN - 0140-6736
AD - Lobel, H. O.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950810390. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Subject Subsets: Protozoology
N2 - A table shows the malaria chemoprophylaxis drugs for chloroquine sensitive, chloroquine resistant (low risk) and chloroquine resistant (high risk) situations, as recommended by each of WHO, Germany, USA, Canada, UK, Switzerland, Netherlands and Australia.
KW - antimalarials
KW - guidelines
KW - malaria
KW - parasites
KW - prophylaxis
KW - travel
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - recommendations
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Labelling foods to improve nutrition in the United States.
AU - Wilkening, V.
AU - Dexter, P.
AU - Lewis, C.
JO - Food, Nutrition and Agriculture
JF - Food, Nutrition and Agriculture
Y1 - 1994///
IS - 10
SP - 38
EP - 43
SN - 1014-806X
AD - Wilkening, V.: Nutrition Regulations Unit, United States Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19951403920. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Subject Subsets: Human Nutrition
N2 - US efforts to establish comprehensive and far-reaching nutrition labelling regulations are used to illustrate some of the many factors that should be considered in developing labelling policies. The subject is discussed under the following headings: development of nutrition labelling in the USA; foods requiring nutrition labelling; content of the label; daily values and serving sizes; nutrient content claims; health claims; nutrition education campaigns. It is concluded that as scientific evidence linking the nutrient content of foods to health conditions continues to emerge, public health policy and dietary guidance may shift and may vary from country to country. Each country may establish its own requirements for providing nutrition information through food labelling in the light of its own priorities, which should include educating consumers to understand and use the food label in ways that will improve health and make society the greatest beneficiary.
KW - food policy
KW - foods
KW - health
KW - information
KW - labelling
KW - nutrition
KW - nutrition education
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Activation of alveolar macrophages by conidia of common fungi associated with organic dust toxic syndrome.
AU - Sorenson, W. G.
AU - Shahan, T. A.
AU - Lewis, D. M.
A2 - Samson, R. A.
A2 - Flannigan, B.
A2 - Flannigan, M. E.
A2 - Verhoeff, A. P.
A2 - Adan, O. C. G.
A2 - Hoekstra, E. S.
T2 - Health implications of fungi in indoor environments.
JO - Health implications of fungi in indoor environments.
JF - Health implications of fungi in indoor environments.
Y1 - 1994///
SP - 325
EP - 343
CY - Amsterdam; Netherlands
PB - Elsevier Science
SN - 0444819975
AD - Sorenson, W. G.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
N1 - Accession Number: 19951202634. Publication Type: Miscellaneous. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The inflammatory potential of the conidia of fungi isolated from samples associated with outbreaks of organic dust toxic syndrome (ODTS) was investigated in vitro. Diffusates (materials released from viable conidia during incubation in macrophage culture media) as well as viable and heat-killed conidia were used to study the production of superoxide anion, leukotriene B4, interleukin 1 (IL-1), complement component C5a and chemotactic factors from cultures of rat and guineapig alveolar macrophages (AM). Results showed differential responses to conidia of several species of Aspergillus (A. fumigatus, A. amstelodami, A. candidus, A. niger and A. terreus) as well as Penicillium spinulosum and Cladosporium cladosporioides. A. fumigatus, A. niger and A. amstelodami inhibited LPS-stimulated IL-1 production while the other species had little or no effect. Incubation of AM with conidia of all species resulted in the release of leukotriene B4 from rat AM, increased superoxide anion production and activation of complement. Diffusates from A. niger had a direct chemotactic effect for human PMN and rat AM. Treatment of rat and guineapig AM with living conidia of A. terreus, A. fumigatus and A. niger resulted in production of chemoattractant activity factors for human PMN. It is suggested that inhalation of large numbers of conidia from these fungi could lead to inflammation and could explain their role in ODTS.
KW - immunology
KW - macrophages
KW - Aspergillus candidus
KW - Aspergillus fumigatus
KW - Aspergillus niger
KW - Aspergillus terreus
KW - Cladosporium cladosporioides
KW - Mycosphaerellaceae
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Cladosporium
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - Mycosphaerella
KW - Mycosphaerellaceae
KW - Penicillium
KW - activation
KW - Aspergillus amstelodami
KW - fungus
KW - Hyphomycetes
KW - mitosporic fungi
KW - Mycosphaerella tassiana
KW - organic dust toxic syndrome
KW - Penicillium spinulosum
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Lyme disease/Lyme borreliosis.
AU - Piesman, J.
AU - Gray, J. S.
A2 - Sonenshine, D. E.
A2 - Mather, T. N.
T2 - Ecological dynamics of tick-borne zoonoses.
Y1 - 1994///
CY - New York; USA
PB - Oxford University Press
SN - 0195073134
AD - Piesman, J.: Lyme Disease Vector Section, Division of Vector-borne Infectious Diseases, Centers for Disease Control, US Public Health Service, PO Box 2087, Foothills Campus, Fort Collins, CO 80422, USA.
N1 - Accession Number: 20000504127. Publication Type: Book chapter. Language: English. Number of References: 6 pp. of ref. Subject Subsets: Medical & Veterinary Entomology
KW - acaricides
KW - chemical control
KW - disease control
KW - disease vectors
KW - ectoparasites
KW - environmental management
KW - epidemiology
KW - Lyme disease
KW - reviews
KW - small mammals
KW - tickborne diseases
KW - vector control
KW - wild animals
KW - zoonoses
KW - Europe
KW - North America
KW - Acari
KW - Borrelia burgdorferi
KW - deer
KW - Ixodes
KW - Ixodes ricinus
KW - Ixodes scapularis
KW - man
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Homo
KW - Hominidae
KW - Primates
KW - America
KW - bacterium
KW - lyme borreliosis
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Animal Ecology (ZZ332)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Changing ecology of Rocky Mountain spotted fever.
AU - Schriefer, M. E.
AU - Azad, A. F.
A2 - Sonenshine, D. E.
A2 - Mather, T. N.
T2 - Ecological dynamics of tick-borne zoonoses.
Y1 - 1994///
CY - New York; USA
PB - Oxford University Press
SN - 0195073134
AD - Schriefer, M. E.: Lyme Disease Vector Section, Division of Vector-borne Infectious Diseases, Centers for Disease Control, US Public Health Service, PO Box 2087, Foothills Campus, Fort Collins, CO 80422, USA.
N1 - Accession Number: 20000504126. Publication Type: Book chapter. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
KW - disease vectors
KW - ecology
KW - ectoparasites
KW - epidemiology
KW - human diseases
KW - reviews
KW - Rocky Mountain spotted fever
KW - small mammals
KW - tickborne diseases
KW - wild animals
KW - zoonoses
KW - USA
KW - Acari
KW - Dermacentor andersoni
KW - Dermacentor variabilis
KW - Ixodidae
KW - man
KW - Rickettsia rickettsii
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Animal Ecology (ZZ332)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000504126&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Assessing environmental risk - scientifically defensible or fantasy?
AU - Houk, V. N.
A2 - Draper, W. M.
T2 - Environmental epidemiology: effects of environmental chemicals on human health. A symposium sponsored by the Division of Environmental Chemistry, Inc. at the 203rd national meeting of the American Chemical Society, San Francisco, California, April 5-10, 1992
T3 - Advances in Chemistry Series No.241
Y1 - 1994///
CY - Washington; USA
PB - American Chemical Society
SN - 0841225176
AD - Houk, V. N.: National Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023024541. Publication Type: Book chapter; Conference paper. Note: Advances in Chemistry Series No.241 Language: English. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - This paper discusses the role of epidemiological studies in humans, in addition to animal studies, in environmental risk assessment, and provides 2 examples of chemical exposure (lead and dioxins) that used both human and animal data to assess adverse effects.
KW - adverse effects
KW - animal experiments
KW - dioxins
KW - epidemiological surveys
KW - epidemiology
KW - exposure
KW - human diseases
KW - lead
KW - reviews
KW - risk assessment
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - animal research
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023024541&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food, filth and disease: a review.
AU - Gorham, J. R.
A2 - Hui, Y. H.
A2 - Gorham, J. R.
A2 - Murrell, K. D.
A2 - Cliver, D. O.
T2 - Foodborne disease handbook: diseases caused by hazardous substances. Volume 3.
Y1 - 1994///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824791665
AD - Gorham, J. R.: Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19951415252. Publication Type: Book chapter. Language: English. Number of References: 61 ref. Subject Subsets: Human Nutrition
KW - food contamination
KW - food poisoning
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951415252&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Hard foreign objects as a cause of injury and disease: a review.
AU - Gorham, J. R.
A2 - Hui, Y. H.
A2 - Gorham, J. R.
A2 - Murrell, K. D.
A2 - Cliver, D. O.
T2 - Foodborne disease handbook: diseases caused by hazardous substances. Volume 3.
Y1 - 1994///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824791665
AD - Gorham, J. R.: Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19951415250. Publication Type: Book chapter. Language: English. Number of References: 54 ref. Subject Subsets: Human Nutrition
KW - diseases
KW - food contamination
KW - reviews
KW - trauma
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - traumas
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951415250&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Drug residues in foods of animal origin.
AU - Long, A. R.
AU - Roybal, J. E.
A2 - Hui, Y. H.
A2 - Gorham, J. R.
A2 - Murrell, K. D.
A2 - Cliver, D. O.
T2 - Foodborne disease handbook: diseases caused by hazardous substances. Volume 3.
Y1 - 1994///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824791665
AD - Long, A. R.: Food and Drug Administration, Denver, CO, USA.
N1 - Accession Number: 19951415244. Publication Type: Book chapter. Language: English. Number of References: 60 ref. Subject Subsets: Veterinary Science; Human Nutrition; Helminthology; Protozoology
N2 - Drug residues in foods of animal origin are discussed under the headings: Historical perspective; Modern animal production/practices; Toxicological significance of residues; Risk/benefit assessment; Responsibility/compliance/enforcement; Importance of analytical methodology; Significant veterinary drugs; Antiprotozoal drugs; Anthelmintics (dewormers); Antibiotics/antibacterials/antimicrobials; Growth promotants; and Future developments.
KW - animal products
KW - anthelmintics
KW - antibiotics
KW - antiinfective agents
KW - antiprotozoal agents
KW - drug residues
KW - food
KW - helminths
KW - meat
KW - parasites
KW - poultry meat
KW - protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - parasitic worms
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Animal Health and Hygiene (General) (LL800)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951415244&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line.
AU - Oravecz, T.
AU - Roderiquez, G.
AU - Koffi, J.
AU - Wang, J.
AU - Ditto, M.
AU - Bou-Habib, D. C.
AU - Lusso, P.
AU - Norcross, M. A.
AU - Dalgleish, A. G.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 1995///
VL - 1
IS - 9
SP - 919
EP - 926
AD - Oravecz, T.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Building 29B, Room 4E12, HFM-541, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952009565. Publication Type: Journal Article. Language: English. Number of References: 45 ref.
KW - cellular biology
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - markers
KW - molecular biology
KW - pathogenesis
KW - tropisms
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CD26
KW - cell biology
KW - cell surfaces
KW - cell tropism
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - monocytotropic viruses
KW - viral entry
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009565&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Distribution of HIV genomic DNA in brains of AIDS patients.
AU - Bockstahler, L. E.
AU - Werner, T.
AU - Festl, H.
AU - Weis, S.
AU - Einhaeupl, K. M.
AU - Erfle, V.
AU - Brack-Werner, R.
JO - Clinical and Diagnostic Virology
JF - Clinical and Diagnostic Virology
Y1 - 1995///
VL - 3
IS - 1
SP - 61
EP - 72
SN - 0928-0197
AD - Bockstahler, L. E.: Molecular Biology Branch, Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19952009652. Publication Type: Journal Article. Language: English. Number of References: 15 ref.
KW - brain
KW - brain diseases
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - polymerase chain reaction
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - brain disorders
KW - cerebrum
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009652&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis.
AU - Badawi, A. F.
AU - Mostafa, M. H.
AU - Probert, A.
AU - O'Connor, P. J. O.
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
Y1 - 1995///
VL - 4
IS - 1
SP - 45
EP - 59
SN - 0959-8278
AD - Badawi, A. F.: Office of Research (HFT 100), National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19950809150. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Subject Subsets: Helminthology
N2 - The relationship between schistosome infection due to Schistosoma haematobium and bladder cancer is discussed under the headings: evidence associating bladder cancer with schistosomiasis (geographical correlation, age and gender ratio, site of tumour origin, histopathological identity, evidence from experimental schistosomiasis); aetiology of schistosome-associated bladder cancer (disordered tryptophan metabolism, elevated levels of β-glucuronidase, the role of N-nitroso compounds). Although the causative role of schistosomiasis is now accepted, various associated factors have been proposed in the induction of this particular type of cancer. While all may contribute to the carcinogenic process, none has yet been confirmed.
KW - aetiology
KW - bladder
KW - bladder cancer
KW - helminths
KW - neoplasms
KW - parasites
KW - schistosomiasis
KW - man
KW - Schistosoma haematobium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - cancers
KW - causal agents
KW - etiology
KW - parasitic worms
KW - schistosomosis
KW - Strigeida
KW - urinary bladder
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950809150&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lyme disease (borreliosis): a global perspective.
AU - Burgdorfer, W.
JO - Alpe Adria Microbiology Journal
JF - Alpe Adria Microbiology Journal
Y1 - 1995///
VL - 4
IS - 4
SP - 227
EP - 233
SN - 1121-9750
AD - Burgdorfer, W.: Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, 903 South Fourth street, Hamilton, MT 59840, USA.
N1 - Accession Number: 19960503177. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
KW - disease vectors
KW - human diseases
KW - Lyme disease
KW - reviews
KW - zoonoses
KW - Borrelia burgdorferi
KW - Ixodes
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - lyme borreliosis
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503177&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Composition of core foods of the U.S. food supply, 1982-1991. 1. Sodium, phosphorus, and potassium.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
AU - Salmon, G. D.
AU - Young, B.
AU - Johnson, R. D.
AU - Marts, R. W.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1995///
VL - 8
IS - 2
SP - 91
EP - 128
SN - 0889-1575
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19951411591. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 7723-14-0, 7440-09-7, 7440-23-5. Subject Subsets: Human Nutrition
N2 - Information on the levels of moisture, sodium, phosphorus and potassium in 234 foods analysed as part of the US Food and Drug Administration's Total Diet Study from 1982 to 1991 is provided. Median and mean (± s.d.) values are described for the elements per 100 g and per serving portion. Coefficients of variation (CVs) are also given for the values per 100 g. Major food group sources of the elements include soups, mixed dishes, breakfast and luncheon meats, breads, rolls, pasta, etc., for Na; mixed dishes, meat, dairy products and poultry for P; and mixed dishes, root and tuber vegetables, beans and peas, and dairy products for K. Na, P and K are widely distributed in Total Diet Study foods with 58 (25%), 61 (26%) and 31 (13%) foods, respectively, containing at least 10% of the daily value (DV) per serving portion. The average CVs for foods containing ≥10% of the DV of these elements were 21% for Na, 15% for P and 16% for K.
KW - food composition
KW - foods
KW - phosphorus
KW - potassium
KW - sodium
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411591&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Composition of core foods of the U.S. food supply, 1982-1991. 2. Calcium, magnesium, iron, and zinc.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
AU - Salmon, G. D.
AU - Young, B.
AU - Johnson, R. D.
AU - Marts, R. W.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1995///
VL - 8
IS - 2
SP - 129
EP - 169
SN - 0889-1575
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19951411592. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7440-70-2, 7439-89-6, 7440-66-6. Subject Subsets: Human Nutrition
N2 - Information on the levels of 4 nutritional elements in the 234 foods analysed as part of the Food and Drug Administration's Total Diet Study from 1982 to 1991 is provided. Median and mean (± s.d.) values are given for the elements per 100 g and per serving portion. Coefficients of variation (CVs) are also given for the values per 100 g. Major food group sources of the elements were dairy products, dairy-based desserts and mixed dishes for calcium; nuts, mixed dishes, and bread, rolls, pasta, etc., for magnesium; ready-to-eat cereals, cooked grains, mixed dishes and meat for iron; and meat, mixed dishes and ready-to-eat cereals for zinc. There were 20 (9%), 19 (8%), 43 (18%) and 28 (12%) foods containing ≥10% of the daily value (DV) for Ca, Mg, Fe and Zn, respectively, per serving portion. The average CVs for foods containing ≥10% of the DV of these elements were 22% for Ca, 17% for Mg, 28% for Fe and 22% for Zn.
KW - calcium
KW - food composition
KW - foods
KW - iron
KW - minerals
KW - trace elements
KW - zinc
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - microelements
KW - United States of America
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411592&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Composition of core foods of the U.S. food supply, 1982-1991. 3. Copper, manganese, selenium and iodine.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
AU - Salmon, G. D.
AU - Young, B.
AU - Johnson, R. D.
AU - Marts, R. W.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1995///
VL - 8
IS - 2
SP - 171
EP - 217
SN - 0889-1575
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19951411593. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 7440-50-8, 7553-56-2, 7439-96-5, 7782-49-2. Subject Subsets: Human Nutrition
N2 - Information on the levels of 4 elements in 234 foods analysed as part of the Food and Drug Administration's Total Diet Study from 1982 to 1991 is provided. Median and mean (± s.d.) values are given for the elements per 100 g and per serving portion. Coefficients of variation (CVs) are also given for the values per 100 g. Major food group sources of the elements were meat, nuts, beans/peas and mixed dishes for copper; ready-to-eat cereals, nuts, cooked grains and beans/peas for manganese; fish, meat, poultry and mixed dishes for selenium; and ready-to-eat cereals, mixed dishes, dairy-based desserts, fish and dairy products for iodine. There were 16 (7%), 40 (17%), 48 (21%) and 81 (35%) foods containing ≥10% of the daily value (DV) or proposed DV for Cu, Mn, Se and I, respectively, per serving portion. The average CVs for foods containing ≥10% of the DV of these elements were 24% for Cu, 28% for Mn, 37% for Se and 158% for I.
KW - copper
KW - food composition
KW - foods
KW - iodine
KW - manganese
KW - selenium
KW - trace elements
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - microelements
KW - Mn
KW - United States of America
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411593&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimalarial chemotherapy: a relentless challenge.
AU - Zucker, J. R.
AU - Campbell, C. C.
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
Y1 - 1995///
VL - 8
IS - 6
SP - 455
EP - 460
SN - 0951-7375
AD - Zucker, J. R.: Malaria Section, Epidemiology Branch, Division of Parasitic Disease, National Center for Infectious Diseases, US Public Health Service, Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19960804538. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 63968-64-9. Subject Subsets: Botanical Pesticides; Protozoology
N2 - This review of chemotherapy of Plasmodium falciparum covers: status of second-line drug regimens in Southeast Asia; artemisinin compounds and derivatives (dosing and clinical experience); mechanisms of drug action and toxicity; new targets and drugs.
KW - antimalarials
KW - antiprotozoal agents
KW - artemisinin
KW - drug therapy
KW - human diseases
KW - malaria
KW - parasites
KW - reviews
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - artemisinine
KW - chemotherapy
KW - qinghaosu
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804538&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Income and AIDS rates in Los Angeles County.
AU - Simon, P. A.
AU - Hu, D. J.
AU - Diaz, T.
AU - Kerndt, P. R.
JO - AIDS
JF - AIDS
Y1 - 1995///
VL - 9
IS - 3
SP - 281
EP - 284
SN - 0269-9370
AD - Simon, P. A.: Division of HIV/AIDS, Centres for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19952006490. Publication Type: Journal Article. Language: English. Number of References: 33 refs.
KW - acquired immune deficiency syndrome
KW - epidemiology
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - income
KW - socioeconomic status
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952006490&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developmental pharmacology and toxicology of anti-HIV therapeutic agents: dideoxynucleosides.
AU - Sandberg, J. A.
AU - Slikker, W., Jr.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 1995///
VL - 9
IS - 12
SP - 1157
EP - 1163
SN - 0892-6638
AD - Sandberg, J. A.: Division of Neurotoxicology, HFT-132,National Center for Toxicological Research/FDA, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19952009729. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Registry Number: 30516-87-1.
KW - animal models
KW - dideoxynucleosides
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - maternal transmission
KW - pharmacology
KW - pregnancy
KW - toxicology
KW - zidovudine
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AZT
KW - gestation
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mother to child transmission
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009729&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Taenia solium cysticercosis: an under-recognized but serious public health problem.
AU - Tsang, V. C. W.
AU - Wilson, M.
JO - Parasitology Today
JF - Parasitology Today
Y1 - 1995///
VL - 11
IS - 3
SP - 124
EP - 126
AD - Tsang, V. C. W.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19950807318. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Helminthology
N2 - The use of the CDC EITB (enzyme-linked immuno-electrotransfer blot) with purified cysticercosis-specific glycoprotein antigen in recent epidemiological studies is described. The serious impact of Taenia solium cysticercosis on public health and the economy of the pork industry is discussed.
KW - cysticercosis
KW - helminths
KW - immunoblotting
KW - immunodiagnosis
KW - metacestodes
KW - parasites
KW - public health
KW - man
KW - Taenia solium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Taenia
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - invertebrates
KW - parasitic worms
KW - pork tapeworm
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950807318&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preparation and characterization of human HIV type 1 neutralizing reference sera.
AU - Vujcic, L. K.
AU - Quinnan, G. V. Jr.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1995///
VL - 11
IS - 7
SP - 783
EP - 787
SN - 0889-2229
AD - Vujcic, L. K.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19952010925. Publication Type: Journal Article. Language: English. Number of References: 20 ref.
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - laboratory methods
KW - neutralization tests
KW - reference standards
KW - serum
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - laboratory techniques
KW - reference reagents
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010925&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence analysis of the V1/V2 and V3 domains in an HIV-seronegative AIDS patient.
AU - Vallejo, A.
AU - Bravo, R.
AU - Heredia, A.
AU - Soriano, V.
AU - Dronda, F.
AU - Hewlett, I. K.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1995///
VL - 11
IS - 12
SP - 1539
EP - 1541
SN - 0889-2229
AD - Vallejo, A.: Correspondence address: I. K. Hewlett, Laboratory of Molecular Virology, Food and Drug Administration, CBER, HFM-315, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19962007139. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
KW - env gene
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - nucleotide sequences
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - V3 loop
KW - variable regions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007139&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of free glutamic acid in a variety of foods by high-performance liquid chromatography.
AU - Daniels, D. H.
AU - Joe, F. L., Jr.
AU - Diachenko, G. W.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1995///
VL - 12
IS - 1
SP - 21
EP - 29
SN - 0265-203X
AD - Daniels, D. H.: Office of Premarket Approval, US Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951405869. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 56-86-0. Subject Subsets: Human Nutrition
N2 - A survey of free glutamic acid concentrations in a variety of foods was conducted. The foods were analysed by HPLC. Free glutamic acid was extracted from the food with 0.02 M potassium phosphate with subsequent precipitation of other food components with acetone. Impurities were removed by passing the extract through a C-8 or C-18 reversed-phase solid-phase extraction column. The free glutamic acid was derivatized with phenylisothiocyanate, and the derivative was separated by HPLC with detection at 254 nm. Free glutamic acid concentrations ranged from not found (<20 mg/kg) in some spices to as high as 89% in another spice.
KW - analytical methods
KW - foods
KW - glutamic acid
KW - HPLC
KW - analytical techniques
KW - high performance liquid chromatography
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405869&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimates of dietary exposure to aluminium.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1995///
VL - 12
IS - 1
SP - 119
EP - 128
SN - 0265-203X
AD - Pennington, J. A. T.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19951405873. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 7429-90-5. Subject Subsets: Human Nutrition
N2 - Daily intakes of aluminium were estimated for 14 age-sex groups based on the Food and Drug Administration's (FDA) Total Diet Study dietary exposure model. The aluminium content of the core foods of the FDA Total Diet Study were estimated by analyses, recipe calculation or literature values and coupled with information on food consumption from the 1987-88 US Department of Agriculture Nationwide Food Consumption Survey. Estimates of aluminium intakes ranged from 0.7 mg/day for 6-11 month-old infants to 11.5 mg/day for 14-16-year-old males. Average intakes for adult men and women were 8-9 and 7 mg/day, respectively. The major contributors to daily intake of aluminium were foods with aluminium-containing food additives, e.g., grain products and processed cheese.
KW - aluminium
KW - food composition
KW - food consumption
KW - intake
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aluminum
KW - United States of America
KW - Diet Studies (VV110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405873&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening procedure for organochlorine and organophosphorus pesticide residues in milk using matrix solid phase dispersion (MSPD) extraction and gas chromatographic determination.
AU - Schenck, F. J.
AU - Wagner, R.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1995///
VL - 12
IS - 4
SP - 535
EP - 541
SN - 0265-203X
AD - Schenck, F. J.: Food and Drug Administration, Baltimore District, 900 Madison Avenue, Baltimore, MD 21201, USA.
N1 - Accession Number: 19950404325. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Dairy Science; Medical & Veterinary Entomology; Agricultural Entomology
N2 - The matrix solid phase extraction (MSPD) rapid technique for the determination of 5 organochlorine and 5 organophosphorus pesticide residues in milk is described. Milk (5.0 ml) is blended with 2.0 g C18 [octadecylsilyl-derivatized silica] and 1.5 ml acetonitrile in a syringe barrel. After the aqueous phase is removed from the column by vacuum aspiration, the pesticide residues are eluted from the C18/milk matrix with acetonitrile which is then eluted through a Florisil solid phase extraction (SPE) column. The acetonitrile is evaporated under nitrogen and the residue is dissolved in petroleum ether. This extract is directly analysed for organophosphorus pesticides by GC with flame photometric detection. After further clean-up of the extract on a mini-Florisil column, the organochlorine pesticide residues are determined by GC with electron capture detection. Grade A homogenized and raw milk samples were fortified with 5 organochlorine and 5 organophosphorus pesticide residues. The average recoveries of fortified organochlorine pesticide residues (2.0-20 ppb) ranged from 76.0 to 97.8%. The average recoveries of fortified organophosphorus pesticide residues (10-50 ppb) ranged from 75.0 to 104.5%. The MSPD and the AOAC International multi-residue method for pesticides in milk produced comparable results for milk samples containing organochlorine pesticide residues. The use of the MSPD method results in a 90% reduction in organic solvent consumption and a 95% reduction in the hazardous waste generated when compared with the AOAC method.
KW - agricultural entomology
KW - analytical methods
KW - contamination
KW - cows
KW - determination
KW - environment
KW - gas chromatography
KW - insecticide residues
KW - insecticides
KW - milk
KW - nontarget effects
KW - organochlorine pesticides
KW - organophosphorus insecticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - residues
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - organic chlorine pesticides
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950404325&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Localization of a protective epitope on a Venezuelan equine encephalomyelitis (VEE) virus peptide that protects mice from both epizootic and enzootic VEE virus challenge and is immunogenic in horses.
AU - Hunt, A. R.
AU - Roehrig, J. T.
JO - Vaccine
JF - Vaccine
Y1 - 1995///
VL - 13
IS - 3
SP - 281
EP - 288
SN - 0264-410X
AD - Hunt, A. R.: National Centre for Infectious Disease, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19962207517. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - In order to define more precisely the protective epitope encoded within the first 25 amino acids (aa) of the E2 glycoprotein of the Trinidad donkey strain of Venezuelan equine encephalomyelitis (VEE) virus, the immunogenicity of smaller peptides within the first 19 aa were examined. pep1-9 and pep3-10 elicited virus-reactive antibody, but failed to protect mice from virus challenge. Additionally, pep3-10 was identified by a competitive binding assay using overlapping peptide octamers as the putative binding site of the antipeptide monoclonal antibody (mAb) 1A2B-10. Since the E2 amino-terminal sequence for all VEE subtype viruses is conserved, the protective capacity in mice of passively transferred mAb 1A2B-10 was tested and was found to protect from both epizootic and enzootic VEE virus challenge. Since horses are an important natural host for VEE virus, pe4p1-19 was used to immunize horses and was found to be immunogenic and to elicit virus-reactive antibody.
KW - antigens
KW - arboviruses
KW - horse diseases
KW - inactivated vaccines
KW - vaccines
KW - viral diseases
KW - equine encephalomyelitis virus
KW - horses
KW - venezuelan equine encephalitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - equine encephalomyelitis virus
KW - antigenicity
KW - arthropod-borne viruses
KW - immunogens
KW - killed vaccines
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962207517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Lyme disease vaccine candidate outer surface protein A (OspA) in a formulation compatible with human use protects mice against natural tick transmission of B. burgdorferi.
AU - Golde, W. T.
AU - Burkot, T. R.
AU - Piesman, J.
AU - Dolan, M. C.
AU - Capiau, C.
AU - Hauser, P.
AU - Dequesne, G.
AU - Lobet, Y.
JO - Vaccine
JF - Vaccine
Y1 - 1995///
VL - 13
IS - 5
SP - 435
EP - 441
SN - 0264-410X
AD - Golde, W. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19960501969. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Recombinant OspA proteins from 2 OspA divergent strains of Borrelia burgdorferi were tested for their vaccine potential in 3 different strains of mice challenged with laboratory reared ticks (Ixodes scapularis) with a high rate of B. burgdorferi infection. All formulations of the B. burgdorferi s.s. derived OspA vaccine protected all strains of mice when challenged by ticks infected with an OspA homologous strain of the spirochaete, whereas heterologous OspA from B. afzelii did not protect. Furthermore, ticks feeding on protected mice had reduced OspA levels compared to unvaccinated controls.
KW - antigens
KW - disease transmission
KW - disease vectors
KW - experimental infections
KW - immunization
KW - infection
KW - laboratory animals
KW - Lyme disease
KW - surface proteins
KW - vaccines
KW - Acari
KW - Arachnida
KW - Borrelia
KW - Borrelia afzelii
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - mice
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Borrelia
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - antigenicity
KW - bacterium
KW - immune sensitization
KW - immunogens
KW - lyme borreliosis
KW - membrane proteins
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960501969&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary fructose alters the insulin-like effects of dietary vanadate in adipocytes from rats.
AU - Blakely, S. R.
AU - Mislo, B. L.
AU - Basi, N. S.
AU - Pointer, R. H.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1995///
VL - 15
IS - 1
SP - 25
EP - 35
SN - 0271-5317
AD - Blakely, S. R.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19951403343. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 57-48-7, 50-99-7, 9004-10-8, 7440-62-2. Subject Subsets: Human Nutrition; Sugar Industry
N2 - This study investigated the acute feeding effects of vanadate and D-fructose on glucose oxidation and lipogenesis in isolated male Wistar rat adipocytes. In a 3-day fasting/refeeding regimen, rats (10/group) weighing 150 to 200 g, were fed on a diet containing glucose (control) or fructose 27% (w/w) with sodium orthovanadate at 0, 25 (vanadate-1) and 50 (vanadate-2) mg/kg of diet. Neither body weight gain nor food efficiency differed between treatment groups, but lower food intake in vanadate-treated rats suggests a compensatory effect of food efficiency in maintaining body weight gain at the same level as in other groups. Basal glucose oxidation to CO2 was enhanced in a dose-related fashion in glucose-vanadate groups, but a significant interaction between fructose and vanadate led to a reduction in vanadate-induced basal glucose oxidation. The reduction in basal and insulin-stimulated glucose conversion to lipid in adipocytes and in hepatic glucose 6-phosphate dehydrogenase and malic enzyme activities by vanadate was not altered by fructose. These results suggest that, under acute feeding, fructose alters the insulin-mimetic aspect of vanadate involving glucose conversion to CO2 in isolated adipocytes.
KW - adipocytes
KW - fructose
KW - glucose
KW - insulin
KW - intake
KW - lipogenesis
KW - oxidation
KW - vanadium
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dextrose
KW - fat cells
KW - fruit sugar
KW - ketohexose
KW - laevulose
KW - levulose
KW - lipid formation
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403343&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of cell proliferation following partial hepatectomy in rats fed NIH-31 or semipurified AIN-76A diets: effects of nucleic acid supplementation.
AU - Jackson, C. D.
AU - Weis, C.
AU - Miller, B. J.
AU - Cross, D. R.
AU - Warbritton, A. R.
AU - James, S. J.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1995///
VL - 15
IS - 10
SP - 1487
EP - 1495
SN - 0271-5317
AD - Jackson, C. D.: Division of Nutritional Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 19951413217. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - Male Fischer 344 rats were administered NIH-31, AIN-76A, or AIN-76A plus 0.25% yeast RNA diets for 3 weeks, partially hepatectomized (PH) and groups of 6 from each diet group were killed at 0, 2, 7 and 14 days following PH. Liver weight, total DNA, total lipids, levels of thiobarbutaric acid reactive substances (TBARS) and levels of intracellular deoxyribonucleotides were estimated. In addition, the number of hepatocytes in mitosis and/or positive for nuclear proliferating cell nuclear antigen (PCNA) were estimated. Liver regeneration, estimated as liver weight or total liver DNA, was equal in the 3 groups and was essentially complete by the end of 14 days. However, there was a 53% reduction in the mitotic index and a 2-fold increase in the ratio of proliferating cells (G1 + S + G2 cells) to mitoses at 48 h in rats of the AIN-76A diet group compared to those fed on NIH-31 diet, suggesting that the cells were arrested or delayed in S-phase. At the time of PH, liver deoxyuridine monophosphate (dUMP) and deoxythymidine triphosphate (dTTP) levels in the AIN-76A group were deceased 29 and 57% respectively, compared to those of the NIH-31 group. Addition of yeast RNA to the AIN-76A diet partially prevented the decrease in mitosis and maintained deoxyribonucleotide triphosphates (dNTP) levels to those of the NIH-31 group. Results indicate that the lack of dietary nucleotides in semipurified diets can alter dNTP levels and have adverse effects on cell proliferation. Consideration should be given to supplementing purified diets with a dietary source of nucleotides.
KW - cell division
KW - diets
KW - effects
KW - hepatectomy
KW - nucleic acids
KW - supplements
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - karyokinesis
KW - liver removal
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413217&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vivo antimutagenic activity of beta-carotene in rat spleen lymphocytes.
AU - Aidoo, A.
AU - Lyn-Cook, L. E.
AU - Lensing, S.
AU - Bishop, M. E.
AU - Wamer, W.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1995///
VL - 16
IS - 9
SP - 2237
EP - 2241
SN - 0143-3334
AD - Aidoo, A.: Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Division of Genetic Toxicology and Computer Sciences Corporation, Jefferson, AR 72079, USA.
N1 - Accession Number: 19961401777. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
N2 - The anticarcinogenic effects of β-carotene (BC) have been extensively investigated, but only in vitro assays have examined the ability to BC to modulate gene mutation. In view of the current interest in the provitamin as a cancer chemopreventive agent, and the association between mutagenesis and carcinogenesis, Fisher 344 rats were dosed with the model carcinogen N-ethyl-N-nitrosourea (ENU) and investigated the relationships among BC intake, its tissue accumulation and antimutagen activity. Rats received drinking water supplemented with BC at doses of 0-0.25% ad libitum, using 3 dosing schedules. In one group BC dosing commenced before, and continued for 3 alternating weeks after intraperitoneal injection of 100 mg ENU/kg; another group was given BC only after mutagen treatment. Rats from the first 2 groups were killed 5 weeks post-mutagen treatment, and cells were isolated from the spleen to determine the frequency of 6-thioguanine-resistant (6-TGr) T-lymphocytes. The presence of BC caused a reduction in the frequency of 6-TGr T-cells produced by ENU, but the inhibition was non-linear within the range of BC doses used. BC intake only after mutagen treatment was more effective than the combination of pre- and post-mutagen intake. In the third group, rats were treated with 100 mg ENU/kg, and BC administration was continued at a fixed dose of 0.15% in the drinking water for 2, 4, 6 or 8 weeks. Measurement of the frequency of 6-TGr T-cells at the end of the specified times showed >50% reduction in ENU-mediated mutagenicity throughout the experiment. Analysis of BC levels in the liver and in the spleen following BC intake before and during mutagen exposure revealed higher levels than when BC was given only after mutagen treatment. Continuous intake of BC also showed increased tissue levels. There were some correlations observed between BC tissue levels and the antimutagenic effects for the first 2 groups, but these correlations were not significant, possibly due to the small number of rats used. Taken together, the results demonstrate that intact BC is absorbed, stored, and exerted antimutagenic effects against a chemical carcinogen in rats without first being transformed to retinol in the gastrointestinal tract.
KW - antineoplastic agents
KW - beta-carotene
KW - lymphocytes
KW - spleen
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cytotoxic agents
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961401777&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acquisition and expression of humoral reactivity to antigens of infective stages of filarial larvae.
AU - Bailey, J. W., II
AU - Hightower, A. W.
AU - Eberhard, M. L.
AU - Lammie, P. J.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 1995///
VL - 17
IS - 12
SP - 617
EP - 623
SN - 0141-9838
AD - Bailey, J. W., II: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19960802308. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Helminthology; Tropical Diseases
N2 - Using serum samples obtained by a cross-sectional survey of 172 individuals from 2 neighbourhoods in Leogane, Haiti (where Wuchereria bancrofti is endemic), antibody responses directed against infective stage Brugia pahangi L3 were assayed by ELISA, immunofluorescence (IFA), and immunoblot for the presence of anti-larval antibodies. ELISA results indicated that virtually all members of both neighbourhoods mounted an anti-larval antibody response within the first 5 years of life, suggesting that exposure to infection is universal. In a multiple linear regression analysis that modelled antibody levels as a function of age, gender, microfilaria status, and neighbourhood (as a proxy for transmission intensity), isotype-specific antibody levels were found to be significantly influenced by both age and neighbourhood. Antibodies directed against the surface of L3 also were age-dependent; the prevalence of IgG antibodies detected by IFA was significantly higher in children than in adults. The prevalence of antibody recognition of 16 700 and 72 300 MW L3 antigens on immunoblots was significantly greater for serum samples from microfilaraemic than amicrofilaraemic persons. It is concluded that antibody responses to larval antigens are influenced to varying degrees by age, transmission intensity, and microfilaraemia status.
KW - epidemiology
KW - filariasis
KW - helminths
KW - human diseases
KW - IgG
KW - immune response
KW - immunoglobulins
KW - lymphatic filariasis
KW - parasites
KW - Caribbean
KW - Haiti
KW - Brugia pahangi
KW - man
KW - Wuchereria bancrofti
KW - Brugia
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Wuchereria
KW - America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - Developing Countries
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - West Indies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960802308&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neomycin residues in kidneys of orally dosed non-ruminating calves determined by high-performance liquid chromatographic and microbiological assay methods.
AU - Shaikh, B.
AU - Jackson, J.
AU - Thaker, N. H.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 1995///
VL - 18
IS - 2
SP - 150
EP - 152
SN - 0140-7783
AD - Shaikh, B.: Center for Veterinary Medicine, Food and Drug Administration, BARC-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19952211085. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 1404-04-2. Subject Subsets: Veterinary Science; Veterinary Science
N2 - 6 calves, aged 4-6 days, were dosed orally with neomycin sulphate (33 mg/kg bodyweight) daily for 14 consecutive days. The neomycin residue concentrations in the kidneys at zero withdrawal time were assessed by high-performance liquid chromatographic (HPLC) assay method (average for males 325 µg/g and for females 281 μg/g) and by microbiological assay (average 400µg/g). The results suggests that aminoglycosides are absorbed in the gastrointestinal tract of non-ruminating calves and that both methods used are capable of detecting high residue levels of neomycin in the kidneys.
KW - antibiotics
KW - assays
KW - calves
KW - drug residues
KW - kidneys
KW - neomycin
KW - residues
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aminoglycosides
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952211085&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of Oxyrase® enrichment method for isolation of Campylobacter jejuni from inoculated foods.
AU - Tran, T. T.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 1995///
VL - 21
IS - 6
SP - 345
EP - 347
SN - 0266-8254
AD - Tran, T. T.: Division of Microbiological Studies, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19961300354. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Recovery limits were evaluated for Campylobacter jejuni in an existing food and drug administration (FDA) enrichment broth (EB) formula supplemented with Oxyrase® enzyme. Cultures of C. jejuni were inoculated into EB or EB containing 10% raw milk, raw oysters, crab meat or mushrooms. After 24 and 48 h of enrichment, C. jejuni was isolated on four selective agars. No significant differences in recovery rates for C. jejuni were observed in the Oxyrase® enrichment under normal atmosphere or in the existing FDA method under modified atmosphere. Increase of enrichment time from 24 to 48 h did not improve the recovery rates. However, the Oxyrase® enrichment was cost effective, less time consuming, and simpler to perform than the established method.
KW - analytical methods
KW - biodeterioration
KW - contamination
KW - detection
KW - edible fungi
KW - enrichment
KW - evaluation
KW - foods
KW - isolation
KW - milk
KW - mushrooms
KW - oysters
KW - pathogens
KW - techniques
KW - bacteria
KW - Campylobacter jejuni
KW - crabs
KW - fungi
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - prokaryotes
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - analytical techniques
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Microbiology (General) (ZZ390)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961300354&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Raccoon rabies in the mid-Atlantic (epidemic) and southeastern states (endemic), 1970-1986: an evaluation of reporting methods.
AU - Torrence, M. E.
AU - Beck, A. M.
AU - Glickman, L. T.
AU - Pérez, C. M.
AU - Samuels, M. L.
JO - Preventive Veterinary Medicine
JF - Preventive Veterinary Medicine
Y1 - 1995///
VL - 22
IS - 3
SP - 197
EP - 211
SN - 0167-5877
AD - Torrence, M. E.: Division of Surveillance, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20855, USA.
N1 - Accession Number: 19952208269. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - This study evaluates the current method of rabies reporting in the USA to assess its ability to reflect temporal trends of animal rabies transmission as epidemiological patterns change. Currently, the Centers for Disease Control and Prevention report only the numbers of animals confirmed rabid in each state. The reported data from three with a raccoon rabies epidemic (Pennsylvania, West Virginia and Virginia) and three states with endemic raccoon rabies from 1970 to 1986 (Florida, Georgia and South Carolina) were analysed by calculating the percent of animals testing positive for rabies from state records and plotting them, using modified smoothing splines. These data were compared with the number of animals testing positive for rabies. Additionally, correlation between reported cases of raccoon rabies and rabies in other species (bats, pets and wildlife) was analysed. The findings indicated that the reported numbers of positive animals by themselves should not be used to assess changes in rabies frequency. The percent rabies positive of the total tested was more reflective of temporal changes of rabies occurrence in the population and of the known patterns of rabies transmission between raccoons and other terrestrial species. It is concluded that reporting the percent positive of those examined for rabies requires not collecting new data, but rather the reporting of total number of animals tested, and a simple calculation of information reported.
KW - data collection
KW - epidemiological surveys
KW - epidemiology
KW - evaluation
KW - methodology
KW - rabies
KW - viral diseases
KW - wild animals
KW - Usa
KW - cats
KW - Chiroptera
KW - dogs
KW - Procyon lotor
KW - Procyonidae
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Procyon
KW - Procyonidae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - data logging
KW - methods
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952208269&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Information sources of U.S. adults trying to lose weight.
AU - Heaton, A. W.
AU - Levy, A. S.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1995///
VL - 27
IS - 4
SP - 182
EP - 190
SN - 0022-3182
AD - Heaton, A. W.: Division of Market Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951411824. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - It was investigated whether dieters differ from nondieters in how and where they obtain nutrition and health information and whether choice of weight-loss practices is related to use of different information sources. A national (USA) telephone survey of a probability sample of 1649 adults provided detailed information on the weight-loss practices of 1431 dieters and comparable background information on 218 nondieters. Dieters were more active readers of nutrition information than were nondieters. However, their choices about type of regimen and about specific products and services were more heavily dependent on word of mouth, commercial sources and physicians than on written information. Dieters relying on written materials were more likely to engage in healthy weight-loss regimens and less likely to engage in questionable weight-loss practices, suggesting that if authoritative written information about specific weight-loss practices was available, it would be used and would likely be effective.
KW - adults
KW - body weight
KW - information
KW - information services
KW - nutrition
KW - weight reduction
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - information sources
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951411824&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serological survey of Neotropical bats in Guatemala for virus antibodies.
AU - Ubico, S. R.
AU - McLean, R. G.
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
Y1 - 1995///
VL - 31
IS - 1
SP - 1
EP - 9
SN - 0090-3558
AD - Ubico, S. R.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, U.S. Public Health Service, Department of Human Health and Human Services, Fort Collins, CO 80552, USA.
N1 - Accession Number: 19950507187. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - Neotropical bats were collected from different life zones in Guatemala in 1983 and 1984 to determine the presence and distribution of antibody against 10 viruses. Bats were collected with mist nets at 13 sites in 8 departments and 332 serum specimens were obtained for testing for neutralizing (N) antibody by the plaque-reduction neutralization test. 87 (26%) of the 332 bats from 16 (38%) of 42 bat species sampled (including Artibeus intermedius, A. jamaicensis, A. lituratus, A. phaeotis, Carollia brevicauda, C. subrufa, Desmodus rotundus, Glossophaga soricina, Phyllostomus discolor, Rhynchonycteris naso, Sturnira lilium, S. ludovici and Vampyrodes caraccioli) were serologically positive for 5 of 6 arboviruses and for 2 other viruses tested. Antibodies against Venezuelan equine encephalitis (VEE) variant I-A/B, eastern equine encephalitis, western equine encephalitis, St. Louis encephalitis, vesicular stomatitis, Tacaribe and Rio Bravo viruses were detected in resident species of bats. However, N antibodies against the enzootic strain of VEE (Mena II, variant I-E) or Nepuyo viruses were not detected.
KW - arboviruses
KW - dog diseases
KW - epidemiology
KW - horse diseases
KW - serological surveys
KW - vesicular stomatitis viruses
KW - viral diseases
KW - wild animals
KW - zoonoses
KW - Guatemala
KW - Artibeus jamaicensis
KW - Artibeus lituratus
KW - Artibeus phaeotis
KW - Carollia
KW - Carollia brevicauda
KW - Carollia subrufa
KW - Chiroptera
KW - Desmodus rotundus
KW - dogs
KW - eastern equine encephalitis virus
KW - Glossophaga
KW - Glossophaga soricina
KW - horses
KW - Phyllostomus
KW - Phyllostomus discolor
KW - Rhynchonycteris
KW - Rhynchonycteris naso
KW - Rio Bravo virus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Sturnira
KW - Sturnira lilium
KW - Sturnira ludovici
KW - Tacaribe virus
KW - Vampyrodes caraccioli
KW - Venezuelan equine encephalitis virus
KW - western equine encephalitis virus
KW - Artibeus
KW - Phyllostomidae
KW - Chiroptera
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Desmodus
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - Flavivirus
KW - Flaviviridae
KW - Vesiculovirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - Carollia
KW - Glossophaga
KW - Phyllostomus
KW - Emballonuridae
KW - Rhynchonycteris
KW - Sturnira
KW - Arenavirus
KW - Arenaviridae
KW - Vampyrodes
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - arthropod-borne viruses
KW - Artibeus intermedius
KW - seroepidemiology
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - vesicular stomatitis virus
KW - viral infections
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health assessment for dioxins exposure from soil.
AU - Pohl, H.
AU - DeRosa, C.
AU - Holler, J.
JO - Chemosphere
JF - Chemosphere
Y1 - 1995///
VL - 31
IS - 1
SP - 2437
EP - 2454
SN - 0045-6535
AD - Pohl, H.: Division of Toxicology, Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19951909326. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Soils & Fertilizers
N2 - Dioxin-contaminated soil may result in dioxins occurring in a food chain. This is especially important for the general population. It has been estimated that about 98% of exposure to dioxins is through the oral route. In the 1980s, a concn level of 1 ppb 2,3,7,8-tetrachlorodibenzo-o-dioxin (TCDD) in soil was specified as "a level of concern", based on cancer effects. However, recent studies indicate that end points other than cancer are also of concern. A health risk analysis scenario based on health effects of TCDD other than cancer is discussed and compared with the projected intake from 1 ppb TCDD in soil.
KW - dioxins
KW - exposure
KW - intake
KW - organic compounds
KW - pollution
KW - public health
KW - soil
KW - toxicity
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - environmental pollution
KW - organic chemicals
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pollution and Degradation (PP600)
KW - Industrial Wastes and Effluents (XX400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dispersal of the Lyme disease spirochete Borrelia burgdorferi to salivary glands of feeding nymphal Ixodes scapularis (Acari: Ixodidae).
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1995///
VL - 32
IS - 4
SP - 519
EP - 521
SN - 0022-2585
AD - Piesman, J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control & Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19950506846. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Salivary gland explant cultures from 3 of 16 (19%) of unfed nymphal I. scapularis contained Lyme disease spirochaetes, increasing to a maximum of 14 of 16 (88%) at 72 h of tick feeding. Homogenates of tick salivary glands did not produce infection in laboratory white mice unless harvested from ticks attached for ≥60 h. Dispersal of spirochaetes to the salivary glands appears to occur during the act of tick feeding, thus affecting the ability of ticks to transmit B. burgdorferi.
KW - disease transmission
KW - disease vectors
KW - epidemiology
KW - feeding
KW - infection
KW - laboratory animals
KW - Lyme disease
KW - salivary glands
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - mice
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - lyme borreliosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of initiation and promotion potential of deoxynivalenol for skin tumorigenesis in Sencar mice.
AU - Lambert, L. A.
AU - Hines, F. A.
AU - Eppley, R. M.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1995///
VL - 33
IS - 3
SP - 217
EP - 222
SN - 0278-6915
AD - Lambert, L. A.: Cosmetics Toxicology Branch, Division of Science and Applied Technology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19951201070. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 51481-10-8. Subject Subsets: Medical & Veterinary Mycology
N2 - Deoxynivalenol (DON; vomitoxin) was tested for its potential to initiate or promote skin tumours through a 2-stage treatment regimen in female Sencar mice. DON's capability for initiation was tested by applying a single topical dose (200 µg) followed by multiple treatments of the promoter phorbol 12-myristate 13-acetate (PMA). The test for promotion involved initiation with the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) followed by multiple DON treatments (50 µg). Appropriate control groups were included in the study design. Mice were observed for 26 wk and skin tumours were counted. Results of the study showed that DON was not an initiator or a promoter. When DON was tested as an initiator, there were no statistically significant differences in the number of cumulative tumours or the number of tumour-bearing mice between the DON-initiated/PMA-promoted group and its control, the vehicle-initiated/PMA-promoted group. When DON was administered as a promoter, no tumours were observed. Histopathology of the skin revealed that DON induced a mild diffuse squamous hyperplasia, but there was no progression of the lesion to neoplasia.
KW - carcinogenesis
KW - mycotoxicoses
KW - poisoning
KW - skin
KW - toxicity
KW - vomitoxin
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxynivalenol
KW - dermis
KW - mycotoxin poisoning
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatitis C virus RNA in factor VIII concentrates.
AU - Guo, Z. P.
AU - Yu, M. W.
JO - Transfusion
JF - Transfusion
Y1 - 1995///
VL - 35
IS - 2
SP - 112
EP - 116
SN - 0041-1132
AD - Guo, Z. P.: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19952010372. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 113189-02-9, 63231-63-0. Subject Subsets: Public Health
N2 - A total of 183 lots of antihaemophilic factor (human) (AHF) made by 6 USA-licensed manufacturers from anti-hepatitis C virus (HCV)-unscreened (1976-1991) or screened (1992-1993) plasma were examined. Detection and quantitation of HCV RNA were achieved by reverse transcription and nested polymerase chain reaction at limiting dilution. Anti-HCV in AHF was also measured. Earlier AHF lots subjected to non-virus-inactivated treatment (36 lots), dry heat (11 lots), or heating in n-heptane (4 lots) had relatively high levels of HCV RNA. Most (76%) wet-heated lots prepared before 1992 contained HCV RNA. No HCV RNA was detected in lots purified by immunoaffinity and subsequently heated or solvent/detergent (S/D)-treated. However, trace levels of HCV RNA were detected in S/D-treated lots made by 1 of 4 manufacturers before 1992. Since the start of anti-HCV plasma screening in 1992, 38 lots prepared by 6 manufacturers were negative for HCV RNA. Prevalence of anti-HCV was also associated with earlier concentrates and with S/D-treated lots from that single manufacturer. Anti-HCV screening of plasma by manufacturers in conjunction with current virus-inactivation procedures, wet-heating or S/D treatment (either process with or without affinity purification), appears to reduce HCV RNA to undetectable levels in AHF.
KW - detection
KW - factor VIII
KW - hepatitis C
KW - human diseases
KW - RNA
KW - North America
KW - USA
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - ribonucleic acid
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952010372&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Applications of antioxidants in physiologically functional foods: safety aspects.
AU - Hathcock, J. N.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1995///
VL - 35
IS - 1/2
SP - 161
EP - 166
SN - 1040-8398
AD - Hathcock, J. N.: Office of Special Nutritionals, U.S. Food and Drug Administration, 8301 Muirkirk Road, HFS-465, Room 1011, Laurel, MD 20708-2476, USA.
N1 - Accession Number: 19951403540. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
KW - antioxidants
KW - food safety
KW - foods
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951403540&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Folate fortification of cereal-grain products: FDA policies and actions.
AU - Yetley, E. A.
AU - Rader, J. I.
JO - Cereal Foods World
JF - Cereal Foods World
Y1 - 1995///
VL - 40
IS - 2
SP - 67
EP - 70,72
SN - 0146-6283
AD - Yetley, E. A.: Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19951405072. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
KW - cereal products
KW - folic acid
KW - food policy
KW - fortification
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - folacin
KW - folate
KW - United States of America
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Crop Produce (QQ050)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951405072&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacterial succession within a biofilm in water supply lines of dental air-water syringes.
AU - Tall, B. D.
AU - Williams, H. N.
AU - George, K. S.
AU - Gray, R. T.
AU - Walch, M.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 1995///
VL - 41
IS - 7
SP - 647
EP - 654
SN - 0008-4166
AD - Tall, B. D.: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street, Southwest, Washington, DC 20204, USA.
N1 - Accession Number: 19951303409. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 15 ref.
N2 - A 6-month study was conducted on bacterial colonization and biofilm formation in plastic water supply lines connected to dental air-water syringes. Changes in biofilm flora were observed by both scanning electron microscopy and bacteriological culture. After 7 days many rod- and spiral-shaped bacteria were observed on the ridged surface of the luminal wall of the tubing. By day 30, individual microcolonies were embedded in extracellular polymeric material. By day 120, these microcolonies had begun to coalesce, and by day 180 the biofilm had developed into a multilayered, heterogenous mixture of microcolonies. The mean aerobic plate counts of colony-forming units of planktonic and biofilm populations were, in log10 values, 5.9 ±0.54 /ml and 4.2 ±0.82 /cm², resp. Early colonizers were predominantly Pseudomonas spp., but also included Pastuerella, Moraxella, Ochrobactrum, and Aeromonas spp. Flavobacterium and Acinetobacter spp. were observed later. Many of these organisms are opportunistic pathogens.
KW - biodeterioration
KW - biofilms
KW - characterization
KW - dental health
KW - formation
KW - lines
KW - pathogens
KW - plastic pipes
KW - plastics
KW - succession
KW - syringes
KW - techniques
KW - water supply
KW - Acinetobacter
KW - Aeromonas
KW - bacteria
KW - Flavobacterium
KW - Moraxella
KW - Ochrobactrum
KW - Pseudomonas
KW - Moraxellaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Aeromonadaceae
KW - Aeromonadales
KW - Flavobacteriaceae
KW - Flavobacteriales
KW - Flavobacteria
KW - Bacteroidetes (phylum)
KW - Pseudomonadaceae
KW - Ochrobactrum
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - bacterium
KW - Pastuerella
KW - water supplies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - General Physiology (ZZ340) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951303409&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and validation of a liquid chromatographic method for the determination of furosemide, a diuretic, in bovine milk.
AU - Shaikh, B.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1995///
VL - 43
IS - 8
SP - 2117
EP - 2121
SN - 0021-8561
AD - Shaikh, B.: Center for Veterinary Medicine, US Food and Drug Administration, BARC-East, Building 328A, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19960400032. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 54-31-9. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A rapid and sensitive reversed-phase liquid chromatographic (LC) procedure was developed and validated for the quantitation of furosemide, a diuretic, in bovine milk. Whole milk was defatted by initial centrifugation at room temperature. The resulting skim milk was deproteinated with acetonitrile and centrifuged again. The acetonitrile from the supernatant was evaporated, and the remaining aqueous portion was directly analysed by LC. The LC conditions employed include a Spherisorb 5 ODS 2 column, a phosphate/acetonitrile buffer (pH 3) and a fluorescence detector, set at 272 and 410 nm excitation and emission wavelengths respectively. The average recoveries of furosemide from milk fortified at 5, 10 and 20 p.p.b. were 108, 91 and 85% respectively, with corresponding coefficients of variation of 14, 8 and 6%. The method was validated by assaying milk obtained from a cow dosed intravenously with 500 mg of furosemide. The furosemide concentrations in 8 and 24 h milk samples were approximately 150 and 5 p.p.b. respectively. No furosemide was detected in 32 and 48 h samples.
KW - analytical methods
KW - chromatography
KW - determination
KW - development
KW - diuretics
KW - drug residues
KW - drugs
KW - fluorescence
KW - furosemide
KW - liquid chromatography
KW - milk
KW - skim milk
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960400032&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of spectinomycin residues in bovine milk using liquid chromatography with electrochemical detection.
AU - Schermerhorn, P. G.
AU - Chu PakSin
AU - Kijak, P. J.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1995///
VL - 43
IS - 8
SP - 2122
EP - 2125
SN - 0021-8561
AD - Schermerhorn, P. G.: Center for Veterinary Medicine, US Food and Drug Administration, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19960400033. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 21736-83-4, 22189-32-8, 1695-77-8. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A method capable of quantifying spectinomycin in bovine raw milk was developed and validated for 100-400 ng/ml. In this procedure the milk is centrifuged at -4°C and the top fat layer removed. The defatted milk is deproteinated by precipitation with 30% trichloroacetic acid and centrifugation. The supernatant is washed sequentially with dichloromethane, hexane and ethyl acetate. An aliquot of the separated aqueous layer is prepared for HPLC analysis by mixing with 1-decanesulfonic acid and filtering. The analyte is separated from the matrix components using an ion-pair mobile phase and a reversed-phase column; the analyte is quantified with an electrochemical detector. Mean recoveries are 80% for milk fortified at 100 ng/ml, 76% for milk fortified at 200 ng/ml and 77% for milk fortified at 400 ng/ml. The intralaboratory coefficients of variations are 18, 6 and 9% respectively.
KW - antibiotics
KW - chromatography
KW - detection
KW - determination
KW - drug residues
KW - hplc
KW - liquid chromatography
KW - milk
KW - milk hygiene
KW - raw milk
KW - spectinomycin
KW - high performance liquid chromatography
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960400033&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Purge and trap extraction with GC-MS determination of volatile organic compounds in table-ready foods.
AU - Heikes, D. L.
AU - Jensen, S. R.
AU - Fleming-Jones, M. E.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1995///
VL - 43
IS - 11
SP - 2869
EP - 2875
SN - 0021-8561
AD - Heikes, D. L.: Food and Drug Administration, 11510 West 80th Street, Lenexa, Kansas 66214-3338, USA.
N1 - Accession Number: 19961403383. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 108-88-3. Subject Subsets: Human Nutrition
N2 - A purge and trap procedure was developed for the estimation of volatile organic compounds (VOC) in table-ready foods. VOC analytes are collected on a Vocarb 3000 trap, thermally desorbed, and cryofocussed directly on a capillary DB-624 column with GC-MS quantification. Adequate precision was achieved for 45 of the 60 analytes of US EPA Method 524.2. Recoveries from 9 food samples fortified with these 45 analytes at 100 ppb and analysed in duplicate ranged from 75.1 to 117% and from 61.3 to 160% for those fortified at 10 ppb. Average percentage of recovery standard deviation (%RSD) values were 11.3 and 20.4, respectively. Additionally, 234 table-ready foods of the FDA Total Diet Program were analysed. A total of 77 foods showed residues >50 ppb, 43 had residues >100 ppb. Only 47 items contained no residues. Toluene was the most common residue encountered, with residues in 91 foods. Cake doughnuts contained the highest total VOC residues (802 ppb).
KW - analytical methods
KW - determination
KW - extraction
KW - foods
KW - organic compounds
KW - prepared foods
KW - toluene
KW - volatile compounds
KW - analytical techniques
KW - organic chemicals
KW - prepared dishes
KW - volatile constituents
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403383&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Summary of notifiable diseases, United States 1995.
AU - Koo, D. T.
AU - Dean, A. G.
AU - Montalbano, M. A.
AU - Knowles, C. M.
AU - Adams, D. A.
AU - Copeland, T. M.
AU - Hall, P. A.
AU - Fagan, R. F.
AU - Holden, H. R.
AU - Jones, G. F.
AU - Maddox, C. L.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1995///
VL - 44
IS - 53
SP - 1
EP - 87
SN - 0149-2195
AD - Koo, D. T.: Division of Surveillance and Epidemiology, Epidemiology Program Office, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19972007219. Publication Type: Annual report. Language: English. Number of References: 147 ref.
KW - disease prevalence
KW - diseases
KW - epidemiology
KW - human diseases
KW - incidence
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007219&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Mumps surveillance-United States, 1988-1993.
AU - Loon F. P. L. van
AU - Holmes, S. J.
AU - Sirotkin, B. I.
AU - Williams, W. W.
AU - Cochi, S. L.
AU - Hadler, S. C.
AU - Lindegren, M. L.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1995///
VL - 44
IS - SS-3
SP - 14
EP - 14
SN - 0149-2195
AD - Loon F. P. L. van: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
N1 - Accession Number: 19962001388. Publication Type: Miscellaneous. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - A report summarizing mumps surveillance data which concludes that incidence rates for mumps in the USA have declined substantially since the licensure and widespread use of mumps vaccine. Policies for providing routine vaccination of young children, policies targeting older populations at risk, and the enactment of school immunization laws have all contributed to the decrease in mumps incidence. During 1988-1993, the incidence of mumps decreased further after the number of states with imunization laws increased and the 2-dose vaccination schedule for measles using MMR was initiated.
KW - disease surveys
KW - epidemiology
KW - human diseases
KW - human paramyxoviruses
KW - immunization
KW - immunization programmes
KW - incidence
KW - mumps
KW - vaccines
KW - viral diseases
KW - North America
KW - USA
KW - man
KW - mumps virus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubulavirus
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - disease surveillance
KW - human paramyxovirus
KW - immune sensitization
KW - immunization programs
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962001388&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA policy on the use of databases for nutrition labeling.
AU - Scarbrough, F. E.
AU - Bender, M. M.
JO - Food Technology (Chicago)
JF - Food Technology (Chicago)
Y1 - 1995///
VL - 49
IS - 5
SP - 142
EP - 145
SN - 0015-6639
AD - Scarbrough, F. E.: Office of Food Labelling, Food and Drug Administration, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951409826. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
KW - databases
KW - food legislation
KW - food policy
KW - foods
KW - labelling
KW - nutrition
KW - data banks
KW - labeling
KW - labels
KW - Laws and Regulations (DD500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409826&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Green tobacco sickness: occupational nicotine poisoning in tobacco workers.
AU - Ballard, T.
AU - Ehlers, J.
AU - Freund, E.
AU - Auslander, M.
AU - Brandt, V.
AU - Halperin, W.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 1995///
VL - 50
IS - 5
SP - 384
EP - 389
SN - 0003-9896
AD - Ballard, T.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-21, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19952011113. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 54-11-5. Subject Subsets: Public Health
N2 - In this study the authors describe the investigation of a 1992 outbreak of green tobacco sickness, a form of nicotine poisoning from dermal exposure, among 47 tobacco workers in a five-county region of central and south-central Kentucky. Cases were identified through medical record searches at participating hospitals, as well as from reports submitted to the Occupational Health Nurses in Agricultural Communities programme. A case-control study was undertaken to assess risk factors for green tobacco sickness. In a 20-min telephone interview, 40 cases and 83 controls responded to questions contained in a questionnaire. In 1992, 47 persons (3 were under age 16 years) in the study region sought medical treatment for green tobacco sickness. Twelve persons were hospitalized and 2 required intensive-care treatment. The crude incidence in 1992 was 10.0/1000 tobacco workers. In 1993, 66 cases (7 were under age 16 years) of green tobacco sickness were identified in the study region (i.e., annual incidence of 14.0/1000). A case-control study demonstrated that ill workers were younger, and were more likely to have worked in wet conditions, compared with workers who were not ill. Green tobacco sickness is a common problem among tobacco workers that may be prevented by avoiding work in wet tobacco or by use of protective clothing. Children younger than 16 years of age represented 9% of the green tobacco sickness cases in 1992 and 1993. Current occupational safety and health laws do not address protection of tobacco workers with respect to green tobacco sickness.
KW - farm workers
KW - nicotine
KW - occupational health
KW - occupations
KW - poisoning
KW - tobacco
KW - toxicology
KW - workers
KW - Kentucky
KW - North America
KW - USA
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - green tobacco sickness
KW - toxicosis
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952011113&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total fat and saturated fat in foods by packed column gas-liquid chromatography after acid hydrolysis.
AU - Rader, J. I.
AU - Angyal, G.
AU - O'Dell, R. G.
AU - Weaver, C. M.
AU - Sheppard, A. J.
AU - Bueno, M. P.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1995///
VL - 54
IS - 4
SP - 419
EP - 427
SN - 0308-8146
AD - Rader, J. I.: Food and Drug Administration, Office of Food Labeling, Center for Food Safety and Applied Nutrition, 200 C Street, S.W., Washington DC 20204, USA.
N1 - Accession Number: 19951413751. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - The new definition of total fat in Food and Drug Administration regulations implementing the Nutrition and Labelling and Education Act of 1990 necessitates the quantification of all lipid fatty acids and the summation of their triglyceride equivalents. A gas-liquid chromatographic (GLC) method using a packed column has been developed for quantitative measurement of total fat and saturated fat in foods. Fatty acids are released from food matrices by acid hydrolysis, and then extracted, esterified to their methyl esters and estimated by GLC. Total fat and saturated fat are calculated in accordance with the new definitions of these components. Fat content estimated by the acid hydrolysis-GLC methodology was compared with fat content estimated by a direct AOAC gravimetric method for 23 food products containing between about 1 and 75% fat by weight. For all food products studied, the relationship between the results obtained by the 2 methods was best described by a straight line that had a correlation coefficient of 0.94. Results of repeated extractions and analysis of a milk-based infant formula (SRM 1846) suggest that this material may be useful as a quality control standard.
KW - analytical methods
KW - estimation
KW - fats
KW - foods
KW - saturated fats
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951413751&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.
AU - Pogribny, I. P.
AU - Basnakian, A. G.
AU - Miller, B. J.
AU - Lopatina, N. G.
AU - Poirier, L. A.
AU - James, S. J.
JO - Cancer Research (Baltimore)
JF - Cancer Research (Baltimore)
Y1 - 1995///
VL - 55
IS - 9
SP - 1894
EP - 1901
SN - 0008-5472
AD - Pogribny, I. P.: National Center for Toxicological Research, Food and Drug Administration, Division of Nutritional Toxicology, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951408302. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 9007-49-2, 59-30-3. Subject Subsets: Human Nutrition
N2 - Male weanling Fischer 344 rats were fed on a semipurified diet deficient in the methyl donors methionine, choline and folic acid or a supplemented control diet for a period of about 9 weeks. At intervals of 2, 5 and 7 days, 3 weeks and 9 weeks after initiation of the respective diets, the relative level of DNA strand breaks and the degree of cytosine methylation were quantified in high molecular weight DNA and also within the p53 gene in liver samples from these rats. Genome-wide strand break accumulation was associated with progressive genomic hypomethylation and increased DNA methyltransferase activity. With the use of quantitative PCR as a gene-specific DNA strand break assay, unique DNA strand breaks were detected in exon 5 but not in exons 6 to 8 of the p53 gene, and were accompanied by significant p53 hypomethylation. DNA hypomethylation has been shown to alter the conformation and stability of the chromatin structure, rendering affected regions more accessible to DNA-damaging agents. To examine whether methylation status alters the sensitivity of DNA to strand breakage, DNA in isolated nuclei was methylated in vitro and exposed to endogenous calcium/magnesium-dependent endonuclease activated under defined conditions. The incidence of enzyme-induced DNA strand breaks was decreased significantly with increased DNA methylation. In nuclei isolated from livers of methyl-deficient rats, the hypomethylated DNA was found to be more sensitive to enzyme- and oxidant-induced DNA strand break induction. Taken together, these results provide evidence that DNA strand breaks are induced by high molecular weight DNA and also within the p53 gene in liver tissue from methyl-deficient rats. The increased incidence of these strand breaks in DNA from methyl-deficient rats may be related to alterations in chromatin accessibility associated with DNA hypomethylation.
KW - carcinogenesis
KW - damage
KW - deficiency
KW - DNA
KW - folic acid
KW - lipotropic factors
KW - liver
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - folacin
KW - folate
KW - lipotropes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408302&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An improved rapid technique for isolation of Escherichia coli O157:H7 from foods.
AU - Weagant, S. D.
AU - Bryant, J. L.
AU - Jinneman, K. G.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 1
SP - 7
EP - 12
SN - 0362-028X
AD - Weagant, S. D.: Seattle District Laboratory, U.S. Food and Drug Administration, Bothell, Washington 98041, USA.
N1 - Accession Number: 19951301554. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - A newly revised enrichment and agar-plating system was tested for selectivity and sensitivity in recovery of unstressed and cold-stressed Escherichia coli 0157:H7 from foods. Various foods inoculated with known levels of enterohaemorrhagic Escherichia coli 0157:H7 (EGEC) were tested by enrichment for 6 h at 37°C in modified tryptic soy broth (mTSB) base supplemented with vancomycin, cefsulodin and cefixime, referred to as EHEC enrichment broth (EEB). Subsequently, portions were spread-plated on sorbitol-MacConkey agar supplemented with tellurite and cefixime (TCSMAC). Further selective enrichment was also examined using immunomagnetic separation (IMS) from the EEB prior to spread-plating on TCSMAC agar. These methods were compared to a procedure of enrichment in MTSB (supplemented with novobiocin) at 37°C for 24 h followed by spread-plating of decimal dilutions on haemorrhagic colitis 4-methylumbeliferyl-B-D-glucuronide (HC-MUG) agar. The new enrichment isolation technique was sensitive at a level of one EHEC organism per 10g of food in four food types. This represents an ~ 100-1,000-fold enhancement in sensitivity over the comparative method for foods with high levels of competitive microflora. These enrichment-isolation protocols were also compared in the analysis of naturally contaminated raw undercooked ground beef samples implicated in foodborne illness. EEB-TCSMAC with and without IMS were combined with rapid biochemical tests, and with 0157 latex agglutination and confirmation of toxin genes by polymerase chain reaction (PCR) to provide a completed test within 30 h of initiating testing. The new system was successful in 15 to 17 samples, where only 6 of 17 were found positive by the comparative technique.
KW - beef
KW - biodeterioration
KW - foods
KW - isolation
KW - microbial contamination
KW - pathogens
KW - polymerase chain reaction
KW - recovery
KW - techniques
KW - bacteria
KW - Escherichia coli
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - E. coli
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Meat Produce (QQ030)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951301554&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Postnatal MSG treatment attenuates angiotensin II (AII) induced drinking in rats.
AU - Caputo, F. A.
AU - Scallet, A. C.
JO - Physiology & Behavior
JF - Physiology & Behavior
Y1 - 1995///
VL - 58
IS - 1
SP - 25
EP - 29
SN - 0031-9384
AD - Caputo, F. A.: FDA/National Center for Toxicological Research, Division of Neurotoxicology, Jefferson, AR 72079, USA.
N1 - Accession Number: 19951408820. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 1407-47-2, 142-47-2. Subject Subsets: Human Nutrition
KW - angiotensin
KW - drinking
KW - hypothalamus
KW - injection
KW - monosodium glutamate
KW - water intake
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - drinking behaviour
KW - drinking habits
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951408820&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of template preparation methods from foods for amplification of Escherichia coli O157 Shiga-like toxins type I and II DNA by multiplex polymerase chain reaction.
AU - Jinneman, K. C.
AU - Trost, P. A.
AU - Hill, W. E.
AU - Weagant, S. D.
AU - Bryant, J. L.
AU - Kaysner, C. A.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 7
SP - 722
EP - 726
SN - 0362-028X
AD - Jinneman, K. C.: Seafood Products Research Center, Food and Drug Administration, 22201 23rd Dr. S.E., P.O. Box 3012, Bothell, Washington 98041, USA.
N1 - Accession Number: 19951304457. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9007-49-2.
N2 - Methods were compared for preparation of template DNA for the polymerase chain reaction (PCR) from enrichments of food homogenates seeded with Escherichia coli O157:H7. Samples were enriched for 6 h at 37°C in modified tryptic soy broth supplemented with cancomycin, cefsulodin, and cefixime. Aliquots of the enrichments (10 ml or 1 ml) were analysed by either washing twice with physiological saline or incubating with antibodies to O157 coupled to immunomagnetic beads (Dynal®) followed by resuspending and boiling the samples. A portion of the preparation was used in a multiplex PCR to amplify a 274-bp fragment from the sltI gene and a 364-bp fragment from the sltII gene. PCR amplification of 1-ml portions of enrichment broth was successful at inoculation levels of about 10 cells per g of food. Increasing the test sample volume to 10 ml and/or using an immunomagnetic separation step improved the PCR detection sensitivity to about 1 cell per g; the entire analysis can be completed within 12 h.
KW - amplification
KW - bacterial toxins
KW - biodeterioration
KW - contamination
KW - DNA
KW - foods
KW - methodology
KW - pathogens
KW - polymerase chain reaction
KW - techniques
KW - bacteria
KW - Escherichia coli
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - deoxyribonucleic acid
KW - E. coli
KW - methods
KW - PCR
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951304457&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of Shigella flexneri on vegetables and detection by polymerase chain reaction.
AU - Rafii, F.
AU - Holland, M. A.
AU - Hill, W. E.
AU - Cerniglia, C. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 7
SP - 727
EP - 732
SN - 0362-028X
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19951304458. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - Commercially prepared and packaged fresh vegetables were tested to determine the types and levels of indigenous microflora. Sixteen species of bacteria from 11 genera were identified and titres of up to 1 ×1010 cells per gram of vegetable were observed. To evaluate the survival of Shigella spp. on packaged vegetables, an avirulent insertion mutant of S. flexneri 5 (pHS1059) was added to vegetables. This str. survived in phosphate-buffered saline at pH 7.3 and 5-10°C for > 3 months. It also survived for several days at both ambient and refrigerator temp. when inoculated onto various commercially prepared vegetables. A rapid method for detecting Shigella spp. on vegetables was developed by using the polymerase chain reaction (PCR) to amplify a 118-base-pair DNA fragment from the S. flexneri virulence-associated spa region. The PCR also generated the corresponding fragments from S. sonnei, S. boydii, and Shigella sp. This fragment was also observed when S. flexneri cells were used to artificially contaminate sterile and nonsterile vegetables, but no amplified fragment was observed when the normal microflora of the vegetables were eluted and tested by PCR.
KW - biodeterioration
KW - contamination
KW - detection
KW - foods
KW - pathogens
KW - polymerase chain reaction
KW - survival
KW - techniques
KW - vegetables
KW - bacteria
KW - shigella
KW - Shigella flexneri
KW - prokaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Shigella
KW - bacterium
KW - PCR
KW - vegetable crops
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951304458&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enumeration of viable Listeria species and Listeria monocytogenes in foods.
AU - Heisick, J. E.
AU - Rosas-Marty, L. I.
AU - Tatini, S. R.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 7
SP - 733
EP - 736
SN - 0362-028X
AD - Heisick, J. E.: U.S. Food and Drug Administration, Minneapolis, Minnesota 55401, USA.
N1 - Accession Number: 19951304459. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - A direct plating procedure was developed for the enumeration of Listeria spp. and L. monocytogenes in foods. Both naturally contaminated foods and foods spiked with L. innocua, L. seeligeri, and L. monocytogenes were studied. The enhanced hemolysis agar (EHA) developed by Cox and modified in our study resulted in two types of agar, referred to as listeria enumeration agar (LEA) no. 1 and 2, used for products of lighter and heavier background microbial populations, resp. On LEA plates, total Listeria spp. counts were determined by fluorescence caused by the breakdown of 4-methylylumbelliferyl-β-D-glucoside contained in EHA. L. monocytogenes counts were determined by picking a representative number of hemolytic colonies and stabbing them into a xylose agar plate to distinguish L. monocytogenes from L. seeligeri. Contamination levels of >200 Listeria cells per g of food can be accurately quantified by this procedure with >80% recovery. Counts of <200 Listeria cells per g of food were considered estimates. When the level of contamination was <100 Listeria cells per g of food, the recovery was <58%. Occasionally, with low-level inocula, Listeria was not detected. Nevertheless, when the procedure was combined with incubation of the enrichment mixture (used for the 1:10 direct plating dilution) and subsequent streaking, Listeria contamination could still be detected and the level, therefore, was determined to be between 1 and 150/g.
KW - biodeterioration
KW - culture media
KW - enumeration
KW - foods
KW - pathogens
KW - techniques
KW - bacteria
KW - Listeria
KW - Listeria monocytogenes
KW - prokaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Listeria
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951304459&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of a rapid plate count and MPN methods for enumeration of fecal coliforms and Escherichia coli in soft-shell clams.
AU - Garcia, G. R.
AU - Haymond, R. E.
AU - Sprague, D. M.
AU - Singleton, E. R.
AU - Peeler, J. T.
AU - Lancette, G. A.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 11
SP - 1197
EP - 1200
SN - 0362-028X
AD - Garcia, G. R.: Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225, USA.
N1 - Accession Number: 19961301358. Publication Type: Journal Article. Language: English. Number of References: 13 ref.
N2 - A direct elevated temperature plate count method utilizing modified fecal coliform agar with rosolic acid (ETPC/mFC) was compared to 5-tube and 3-tube most probable number (MPN) procedures for its accuracy in enumerating fecal coliforms and Escherichia coli in naturally and artificially contaminated soft-shell clams (Mya arenaria). The results indicated that the extent of overall recovery of fecal coliforms was similar in the two methods tested. Therefore, the ETPC/mFC method may be considered as a rapid procedure for fecal coliform screening during depuration of soft-shell clams.
KW - biodeterioration
KW - clams
KW - comparisons
KW - contamination
KW - enumeration
KW - faecal coliforms
KW - methodology
KW - pathogens
KW - plate count
KW - techniques
KW - USA
KW - Escherichia coli
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - methods
KW - most probable number method
KW - United States of America
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961301358&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Foodborne illness: perceptions, experience, and preventive behaviors in the United States.
AU - Fein, S. B.
AU - Lin, C. T. J.
AU - Levy, A. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1995///
VL - 58
IS - 12
SP - 1405
EP - 1411
SN - 0362-028X
AD - Fein, S. B.: Division of Market Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administrtion, Washington, D.C. 20204, USA.
N1 - Accession Number: 19961301498. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
KW - biodeterioration
KW - consumers
KW - exposure
KW - food preparation
KW - foodborne diseases
KW - foods
KW - illness
KW - pathogens
KW - perception
KW - prevention
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961301498&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of pulsed-field gel electrophoresis for epidemiological study of Escherichia coli O157:H7 during a food-borne outbreak.
AU - Johnson, J. M.
AU - Weagant, S. D.
AU - Jinneman, K. C.
AU - Bryant, J. L.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1995///
VL - 61
IS - 7
SP - 2806
EP - 2808
SN - 0099-2240
AD - Johnson, J. M.: Seattle District Laboratory, Food and Drug Administration, Bothell, Washington, DC 98041, USA.
N1 - Accession Number: 19962005545. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Food and patient isolates from an Escherichia coli O157:H7 outbreak (in Washington and Oregon, USA) associated with undercooked ground beef were characterized by pulsed-field gel electrophoresis and Shiga-like toxin genotype. Pulsed-field gel electrophoresis confirmed the epidemiologically implicated source of the two-state outbreak and differentiated between outbreak and sporadic strains.
KW - beef
KW - electrophoresis
KW - epidemiology
KW - food poisoning
KW - human diseases
KW - infections
KW - outbreaks
KW - North America
KW - Oregon
KW - USA
KW - Washington
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005545&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perspective on the 1986 Food and Drug Administration assessment of the safety of carbohydrate sweeteners: uniform definitions and recommendations for future assessments.
AU - Glinsmann, W. H.
AU - Park, Y. K.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1995///
VL - 62
IS - 1(S)
SP - 161S
EP - 169S
SN - 0002-9165
AD - Glinsmann, W. H.: Food and Drug Administration, Room 2804, 200 C Street, SW Washington, D.C. 20204, USA.
N1 - Accession Number: 19951409343. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition
N2 - This paper, presented as part of the Workshop on the Evaluation of the Nutritional and Health Aspects of Sugars held in the USA in 1994, discusses the US Food and Drug Administration's safety evaluation of carbohydrate sweeteners. The procedure used to assess safety of these sweeteners is discussed, major findings are noted and these are compared with findings in the UK. Trends in the availability of added and naturally occurring sugars in the USA are reviewed, and recommendations for future assessment of sugars intake are made.
KW - food safety
KW - sugars
KW - sweeteners
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Workshop on the evaluation of the nutritional and health aspects of sugars
KW - Food Additives (QQ130)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951409343&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition labeling: energy values of foods and fat substitutes.
AU - Wiesenfeld, P. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1995///
VL - 62
IS - 5 SUPP
SP - 1143S
EP - 1146S
SN - 0002-9165
AD - Wiesenfeld, P. L.: Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19951414607. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
KW - energy
KW - energy value
KW - foods
KW - labelling
KW - lipid substitutes
KW - nutrition
KW - Advances in human energy metabolism: balancing energy requirements and energy intake
KW - caloric value
KW - calorie value
KW - calorific value
KW - labeling
KW - labels
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414607&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methods available to estimate the energy values of sugar alcohols.
AU - Ellwood, K. C.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1995///
VL - 62
IS - 5 SUPP
SP - 1169S
EP - 1174S
SN - 0002-9165
AD - Ellwood, K. C.: Division of Science and Applied Technology, Office of Special Nutritionals, Food and Drug Administration, Laurel, MD, USA.
N1 - Accession Number: 19951414612. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Sugar Industry
KW - energy value
KW - methodology
KW - polyols
KW - sugar alcohols
KW - Advances in human energy metabolism: balancing energy requirements and energy intake
KW - caloric value
KW - calorie value
KW - calorific value
KW - methods
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19951414612&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heat stress alters the virulence of a rifampin-resistant mutant of Francisella tularensis LVS.
AU - Bhatnagar, N. B.
AU - Elkins, K. L.
AU - Fortier, A. H.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1995///
VL - 63
IS - 1
SP - 154
EP - 159
SN - 0019-9567
AD - Bhatnagar, N. B.: Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.
N1 - Accession Number: 19960500602. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 13292-46-1. Subject Subsets: Medical & Veterinary Entomology
N2 - The authors studied the stress response of a rifampin-resistant mutant of F. tularensis LVS. This mutant, Rif 7, was avirulent with an intraperitoneally administered 50% lethal dose >107 CFU in a murine model of infection. Exposure of Rif 7 to heat stress for 5 h in vitro resulted in a 2-log decrease in its LD50. The increase in virulence was dependent on the time of exposure to high temperature and was maximal at 5 h. Envelope preparations from heat-stressed cells showed increased levels of several proteins. Notable among these were polypeptides with approximate molecular masses of 16, 60 and 75 kDa. Increases in both virulence and envelope protein levels were reversed when heat-treated cells were subsequently grown at 37°C. Inhibition of protein synthesis by actinomycin D [dactinomycin] during heat stress blocked the increase in virulence of Rif 7. Cell-free media from the heat-stressed Rif 7 culture or killed heat-stressed cells were not toxic to mice. Hyperimmune serum against Rif 7 reacted with the whole spectrum of bacterial proteins in Western blots (immunoblots), although its reaction with 34- and 45-kDa protein and two 60- and 75-kDa proteins upregulated during heat stress was weak. Other stress conditions, low iron and low pH, caused similar increases in the virulence of Rif 7. However, examination of the protein profile did not reveal any major common polypeptides induced by different stresses. Heat-reacted Rif 7 bacteria were fully able to replicate in macrophages in vitro and in the host tissues, even though heat treatment only partially restored virulence.
KW - drug resistance
KW - heat stress
KW - laboratory animals
KW - mutants
KW - proteins
KW - rifampicin
KW - temperature
KW - tularaemia
KW - virulence
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - rifampin
KW - rifamycin amp
KW - tularemia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960500602&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Brucella abortus conjugated with a gp120 or V3 loop peptide derived from human immunodeficiency virus (HIV) type 1 induces neutralizing anti-HIV antibodies, and the V3-B. abortus conjugate is effective even after CD4+ T-cell depletion.
AU - Golding, B.
AU - Inman, J.
AU - Highet, P.
AU - Blackburn, R.
AU - Manischewitz, J.
AU - Blyveis, N.
AU - Angus, R. D.
AU - Golding, H.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1995///
VL - 69
IS - 6
SP - 3299
EP - 3307
SN - 0022-538X
AD - Golding, B.: Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pk, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952009350. Publication Type: Journal Article. Language: English. Number of References: 26 ref.
KW - acquired immune deficiency syndrome
KW - antigens
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - humoral immunity
KW - immunology
KW - neutralizing antibodies
KW - research
KW - vaccines
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - antigenicity
KW - conjugated peptides
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunogens
KW - studies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009350&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence variations in the non-repetitive regions of the liver stage-specific antigen-1 (LSA-1) of Plasmodium falciparum from field isolates.
AU - Yang, C.
AU - Shi, Y. P.
AU - Udhayakumar, V.
AU - Alpers, M. P.
AU - Povoa, M. M.
AU - Hawley, W. A.
AU - Collins, W. E.
AU - Lal, A. A.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1995///
VL - 71
IS - 2
SP - 291
EP - 294
SN - 0166-6851
AD - Yang, C.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Mail stop F-12, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950808245. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Protozoology
N2 - The N- and C-terminal regions of the liver-stage-specific antigen-1 gene of 31 Plasmodium falciparum isolates from Kenya (11 isolates), Madang (Papua New Guinea, 10 isolates) and Paragaminos (Brazil, 10 isolates) were compared. Based on the amino acid sequence variation in the N terminus of the gene (61 clones), the parasites from Kenya were categorized into 10 groups (KEN0 to KEN9), those from Madang into 8 (PNG0 to PNG7) and those from Paragaminos into 6 (BRA0 to BRA5). The mutations in the N terminus were mainly clustered in 3 areas designated arbitrarily as regions N1 (amino acids 41 to 60), N2 (82 to 114) and N3 (131 to 150). For the C terminus, 56 clones were sequenced. Parasites from Kenya and Brazil were each categorized into 10 groups (KEN0 to KEN9 and BRA0 to BRA9) and parasites from Madang into 4 groups (PNG0 to PNG3). Point mutations in the C terminus appeared to be randomly distributed through the entire sequence, although there were 2 regions in which the most non-synonymous changes were found (C1, 1644 to 1664, and C2, 1831 to 1869). Parasites from Papua New Guinea and Brazil had fewer sequence variations in both N- and C-termini than did those from Kenya.
KW - antigens
KW - genes
KW - genetic variation
KW - nucleotide sequences
KW - parasites
KW - Brazil
KW - Kenya
KW - Papua New Guinea
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - APEC countries
KW - New Guinea
KW - Melanesia
KW - Australasia
KW - Oceania
KW - Pacific Islands
KW - antigenicity
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - immunogens
KW - liver stages
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808245&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory aspects of mycotoxins in soybean and soybean products.
AU - Nesheim, S.
AU - Wood, G. E.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1995///
VL - 72
IS - 12
SP - 1421
EP - 1423
SN - 0003-021X
AD - Nesheim, S.: Division of Natural Products, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C. Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19961004288. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Plant Pathology; Medical & Veterinary Mycology; Soyabeans; Postharvest Research
N2 - More than 50 countries have enacted or proposed regulations for the control of aflatoxins in foods and/or feeds, and at least 15 of these countries also have regulations for permitted levels of contamination by other mycotoxins. Since 1965, the US Food and Drug Administration has used action levels to control aflatoxins in its compliance programmes. Cooperative programs with the US Department of Agriculture, state agencies and industry have also been used to keep exposure to aflatoxins as low as practical. Soyabeans support the growth of many mould species which can produce toxins such as aflatoxins, trichothecenes (such as T-2) and cytochalasins. The natural occurrence of these toxins in soyabeans has not been a problem. Limited surveys of soyabeans and soya-based infant formulas have not revealed significant contamination. The sequence of events that leads to consideration of a mycotoxin for control programmes and other regulatory activity includes determination of a toxic response, isolation and identification of the toxin, development of a sampling plan and method of analysis, and determination of incidence and levels of contamination of the susceptible commodity. The quality of soyabeans can vary widely, depending on environmental, agronomic and storage conditions. Products susceptible to contamination from improper storage are subject to regulatory action on a case-by-case basis. The government-industry cooperative programmes have been successful in limiting human exposure to aflatoxins.
KW - aflatoxins
KW - biodeterioration
KW - commodities
KW - contamination
KW - feeds
KW - grain legumes
KW - legislation
KW - mycotoxins
KW - plant pathogenic fungi
KW - plant pathogens
KW - plant pathology
KW - regulations
KW - secondary metabolites
KW - soyabean products
KW - soyabeans
KW - toxins
KW - USA
KW - Fabaceae
KW - fungi
KW - Glycine (Fabaceae)
KW - Glycine max
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Glycine (Fabaceae)
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - fungal toxins
KW - fungus
KW - Improving oilseed quality - biocontrol of pathogenic fungi
KW - Improving oilseed quality: biocontrol of pathogenic fungi
KW - phytopathogenic fungi
KW - phytopathogens
KW - phytopathology
KW - plant-pathogenic fungi
KW - pulses
KW - rules
KW - soybean products
KW - soybeans
KW - United States of America
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961004288&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth patterns in selected organs of the miniature swine as determined by gross macromolecular composition.
AU - Friedman, L.
AU - Gaines, D. W.
AU - Newell, R. F.
AU - Smith, M. C.
AU - Braunberg, R. C.
AU - Flynn, T. J.
AU - O'Donnell, M. W., Jr.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1995///
VL - 73
IS - 5
SP - 1340
EP - 1350
SN - 0021-8812
AD - Friedman, L.: Food and Drug Administration, Beltsville Research Facility, Center for Food Safety and Applied Nutrition, 8501 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19951412551. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Human Nutrition; Animal Nutrition
KW - composition
KW - dna
KW - growth
KW - miniature pigs
KW - organs
KW - protein
KW - rna
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - hogs
KW - minipigs
KW - ribonucleic acid
KW - swine
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic procedure for the determination of novobiocin residues in bovine milk: interlaboratory study.
AU - Reeves, V. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 1
SP - 55
EP - 58
SN - 1060-3271
AD - Reeves, V. B.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Agricultural Research Center-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19950403109. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 303-81-1. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - Novobiocin is used for the treatment of mastitis in dairy cattle. In 1982, the tolerance was set at 0.1 p.p.m. in milk from dairy animals. A laboratory trial was completed for a liquid chromatographic procedure that can quantitate novobiocin residues in bovine milk at the tolerance level. In this procedure the milk is diluted with buffer, the proteins are precipitated with methanol and the solution is filtered. Novobiocin is determined after separation of milk components using reversed-phase chromatography with UV detection at 340 nm. The participating laboratories analysed 2 concentrations of biologically incurred residues as well as control milk and control milk fortified at 0.05, 0.1 and 0.2 p.p.m. Recoveries of novobiocin reported by the participating laboratories were 89 to 99% at 0.05 p.p.m.; 93 to 101% at 0.1 p.p.m.; and 89 to 100% at 0.2 p.p.m. CV ranged from 2.0 to 6.2%. The average concentrations for the low levels of incurred novobiocin in milk samples were 0.073, 0.072 and 0.081 p.p.m., with intralaboratory CV of 3.3, 7.2 and 2.4% respectively. The samples with high levels of incurred novobiocin averaged 0.139, 0.121 and 0.144 p.p.m., with CV of 6.2, 0.7 and 4.7% respectively.
KW - antibiotic residues
KW - antibiotics
KW - bacterial diseases
KW - bovine mastitis
KW - cattle diseases
KW - chromatography
KW - cows
KW - determination
KW - drug residues
KW - liquid chromatography
KW - mastitis
KW - milk
KW - milk hygiene
KW - novobiocin
KW - residues
KW - therapy
KW - ultraviolet radiation
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - therapeutics
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of residues of flumequine and nalidixic, oxolinic, and piromidic acids in catfish by liquid chromatography with fluorescence and UV detection.
AU - Munns, R. K.
AU - Turnipseed, S. B.
AU - Pfenning, A. P.
AU - Roybal, J. E.
AU - Holland, D. C.
AU - Long, A. R.
AU - Plakas, S. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 2
SP - 343
EP - 352
SN - 1060-3271
AD - Munns, R. K.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19952215486. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 389-08-2, 14698-29-4. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Veterinary Science
N2 - A liquid chromatographic (LC) method is described for determining residues of flumequine (FLU) and nalidixic (NAL), oxolinic (OXO), and piromidic (PIR) acids in catfish muscle. The identities of 3 of these residues are confirmed by gas chromatography-mass spectrometry (GC-MS). The extraction and cleanup procedures are the same for both determination and identification. Analyte isolation involves homogenizing the tissue with acetone, defatting the acetone extract with hexane, and extracting the compound into chloroform. The extract is further purified by first partitioning into base and subsequently back-extracting into chloroform after acidifying the aqueous phase. After the solvent is evaporated, the residue is dissolved in mobile phase, and the analytes are determined by LC with fluorescence detection, excitation at 325 nm and emission at 365 nm. Catfish muscle was fortified with each quinolone at 5, 10, 20, 40, and 80 ng/g. Overall average recoveries were 83-94%, with relative standard deviations (RSDs) of 5-7%. The method was evaluated also by a second analyst, who determined 4 quinolones added in combination. Average recoveries of quinolones from catfish fortified at 5, 10 and 20 ng/g were 78-90%, with RSDs of 3-6%. The presence in catfish muscle of incurred OXO, FLU, and NAL at the 10 ng/g level was confirmed by analysing the decarboxylated quinolones by GC-MS. The relative abundances of all 5 major ions for OXO, FLU, and NAL were within 10% of those observed in spectra of standard compounds decarboxylated by the same method.
KW - acids
KW - assays
KW - detection
KW - determination
KW - drug residues
KW - fish
KW - fluorescence
KW - liquid chromatography
KW - nalidixic acid
KW - oxolinic acid
KW - quinolones
KW - residues
KW - Ictalurus
KW - Ictalurus punctatus
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictalurus
KW - flumequine
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative effectiveness of selenite cystine broth, tetrathionate broth, and Rappaport-Vassiliadis medium for the recovery of Salmonella from raw flesh and other highly contaminated foods: precollaborative study.
AU - June, G. A.
AU - Sherrod, P. S.
AU - Hammack, T. S.
AU - Amaguana, R. M.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 2
SP - 375
EP - 380
SN - 1060-3271
AD - June, G. A.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19961300912. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 56-89-3.
N2 - The effectiveness of selenite cysteine (SC) broth, tetrathionate (TT) broth, and Rappaport-Vassiliadis (RV) medium for recovery of Salmonella spp. from 8 highly contaminated foods was determined. RV medium prepared from individual ingredients and incubated at 42° and 43°C was compared with 2 commercial (Difco and Oxoid) media incubated at 42°C. Naturally and artificially contaminated foods were tested under 2 protocols. For Protocol 1, each food was pre-enriched in the appropriate medium. After incubation, serial 10 fold dilutions of the pre-enriched foods were inoculated into selective enrichment media and incubated at 35°, 42°, or 43°C. Effectiveness of these conditions was evaluated by most probable number determination of Salmonella spp. recovered. Productivity of selective enrichments did not differ significantly with this protocol, except that with Oxoid RV medium the number of Salmonella cells recovered from most of the foods was significantly reduced. For Protocol 2, twenty 25 g test portions from artificially inoculated foods were examined qualitatively for Salmonella spp. The effectiveness of the broth/temperature combinations was determined by the number of positive tests under each condition. RV medium prepared from individual ingredients and TT broth incubated at 43°C yielded significantly more Salmonella-positive tests from frog legs and lettuce than did SC and TT broths incubated at 42°C. With port sausage and ground beef, significantly fewer Salmonella-positive tests were found with Oxoid RV medium incubated at 42°C and SC incubated at 35°C than from other selective enrichments. With chicken, fewer Salmonella-positive tests were found from SC and TT broths incubated at 35°C and Oxoid RV medium incubated at 42°C than from other selective enrichments. There were no significant differences among selective enrichments in the recovery of Salmonella spp. from the remaining food. Overall, RV prepared from individual ingredients and incubated at 42°C yielded the highest number of Salmonella-positive tests.
KW - biodeterioration
KW - cystine
KW - detection
KW - evaluation
KW - foods
KW - plate count
KW - recovery
KW - techniques
KW - bacteria
KW - salmonella
KW - prokaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multi-column solid-phase extraction cleanup of organophosphorus and organochlorine pesticide residues in vegetable oils and butterfat.
AU - Gillespie, A. M.
AU - Daly, S. L.
AU - Gilvydis, D. M.
AU - Schneider, F.
AU - Walters, S. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 2
SP - 431
EP - 437
SN - 1060-3271
AD - Gillespie, A. M.: U.S. Food and Drug Administration, Pesticides and Industrial Chemicals Research Center, 1560 E. Jefferson Ave, Detroit, MI 48207, USA.
N1 - Accession Number: 19950402916. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 8001-22-7, 8001-21-6. Subject Subsets: Human Nutrition; Dairy Science
N2 - Diatomaceous earth columns used with reversed- and normal solid-phase extraction (SPE) cartridges were evaluated for the quantitative determination of a number of organophosphorus (OP) and organochlorine (OC) pesticide residues in edible vegetable oils and milk fat. An oil or fat sample (approximately 2 g) in hexane was passed through a diatomaceous earth (Extrelut QE) column and a C18 bonded silica (ODS) SPE cartridge, resulting in the separation of the pesticides from approximately 98% of the lipids. The eluate was split in half, with the first portion concentrated into acetone for the determination of OP pesticides by GC with flame photometric detection (GC-FPD). The other half was passed through an Alumina-N SPE cartridge for additional cleanup of lipid matrix to determine OC pesticides by GC with electron-capture detection (GC-ECD). Average recoveries from fortified samples were >89% for the pesticides studied.
KW - chromatography
KW - cows
KW - determination
KW - extraction
KW - gas chromatography
KW - maize oil
KW - milk fat
KW - oils
KW - olive oil
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - plant oils
KW - soyabean oil
KW - sunflower oil
KW - vegetables
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - butterfat
KW - corn oil
KW - organic chlorine pesticides
KW - soybean oil
KW - vegetable crops
KW - vegetable oils
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of malachite green and its metabolite, leucomalachite green, in catfish (Ictalurus punctatus) tissue by liquid chromatography with visible detection.
AU - Roybal, J. E.
AU - Pfenning, A. P.
AU - Munns, R. K.
AU - Holland, D. C.
AU - Hurlbut, J. A.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 2
SP - 453
EP - 457
SN - 1060-3271
AD - Roybal, J. E.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19951201533. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 569-64-2. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology; Veterinary Science
N2 - To determine residues of malachite green (MG) and its metabolite, leucomalachite green (LMG), in catfish tissue, analytes were extracted with acetonitrile-buffer and the extract was partitioned into methylene chloride. Final clean-up and isolation were performed on neutral alumina solid-phase extraction (SPE) and propylsulfonic acid cation-exchange SPE columns before analysis by liquid chromatography with visible detection. PbO2 post-column oxidation was performed by isocratic elution with a buffered mobile phase from a cyano column. Recoveries and relative standard deviations (RSDs) from fortified catfish tissues were 72.9% (RSD, 1.92%; 23 p.p.b.), 75.5% (6.85%; 11 p.p.b.) and 69.6% (6.93%; 5.7 p.p.b.) for MG and 87.4% (2.92%; 21 p.p.b.), 88.1% (5.94%; 10 p.p.b.) and 82.6% (11.5%; 5.3 p.p.b.) for LMG. The method was applied to MG-incurred catfish at depuration times of 0, 2, 4, 8 and 24 h. Mean levels of residual MG and LMG in the 24 h depuration catfish tissue were 73.4 and 289 p.p.b., respectively.
KW - analytical methods
KW - antifungal agents
KW - drug residues
KW - estimation
KW - liquid chromatography
KW - malachite green
KW - residues
KW - tissues
KW - fishes
KW - Ictalurus
KW - Ictalurus punctatus
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - Ictalurus
KW - analytical techniques
KW - fungistats
KW - Aquaculture (Animals) (MM120)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dietary restriction on glutathione S-transferase activity specific toward aflatoxin B1-8,9-epoxide.
AU - Chen Wen
AU - Nichols, J.
AU - Zhou YongGui
AU - Chung KingThom
AU - Hart, R. W.
AU - Chou Ming W.
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 1995///
VL - 78
IS - 3
SP - 235
EP - 243
SN - 0378-4274
AD - Chen Wen: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19951203648. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 50812-37-8. Subject Subsets: Medical & Veterinary Mycology
N2 - The effect of dietary restriction (DR) on male rat liver cytosolic GST activity toward aflatoxin B 1 (AFB1)-8,9-epoxide was studied. The chemically-synthesized AFB1-8,9-epoxide was used as the substrate in this assay and the formation of AFB1-GSH conjugate was analysed by HPLC. Male Fischer 344 rats fed DR diets (60% of the food consumption of ad libitum (AL)-fed rats) showed a 2.4-fold increase in GST activity when AFB1-epoxide was used as the substrate. The results from the enzyme kinetic study showed that DR increased Vmax of the liver cytosolic GST but not the Km. Acute DR had little or no impact on GST activity when 1-chloro-2,4-dinitrobenzene and 2,4-dichloronitrobenzene were used as substrates. The mouse liver GST activity toward AFB1-epoxide was 3-fold greater than that of phenobarbital-induced rats, 4.5-fold greater than DR rats, and 14.7-fold greater than the GST activity of AL rats. It is concluded that this direct assay of liver GST activity using AFB1-epoxide as the substrate is useful for studying AFB1-induced biomarkers, such as AFB1-GSH conjugation and AFB1-DNA adducts.
KW - aflatoxicosis
KW - aflatoxins
KW - diet
KW - energy restricted diets
KW - glutathione transferase
KW - liver
KW - metabolism
KW - mycotoxins
KW - poisoning
KW - susceptibility
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin poisoning
KW - calorie-restricted diets
KW - fungal toxins
KW - ligandin
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of deoxynivalenol in U.S. 1993 wheat and barley crops by enzyme-linked immunosorbent assay.
AU - Trucksess, M. W.
AU - Thomas, F.
AU - Young, K.
AU - Stack, M. E.
AU - Fulgueras, W. J.
AU - Page, S. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 3
SP - 631
EP - 636
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 19951202224. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 51481-10-8. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition; Human Nutrition; Plant Pathology; Postharvest Research; Wheat, Barley & Triticale Abstracts
N2 - Wheat and barley harvested in the USA during 1993 were analysed for deoxynivalenol [vomitoxin] (DON). A total of 630 samples were collected by the Federal Grain Inspection Service in 25 states and analysed using a commercially available, direct competitive ELISA. The limit of determination was approx. 0.5 µg/g. DON contamination in 483 wheat samples averaged 2.0 µg/g and ranged from <0.5 to 18 µg/g. DON contamination in the 147 barley samples averaged 4.2 µg/g and ranged from <0.5 to 26 µg/g. Approx. 40% of the wheat samples and 57% of the barley samples contained DON levels that were greater than the US Food and Drug Administration 1982 advisory level of 2 µg/g for DON in wheat designated for milling (human consumption).
KW - analytical methods
KW - barley
KW - cereals
KW - contamination
KW - ELISA
KW - estimation
KW - mycotoxins
KW - plant pathogenic fungi
KW - plant pathogens
KW - plant pathology
KW - vomitoxin
KW - wheat
KW - USA
KW - fungi
KW - Hordeum
KW - Hordeum vulgare
KW - Triticum
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Hordeum
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - deoxynivalenol
KW - enzyme linked immunosorbent assay
KW - fungal toxins
KW - fungus
KW - phytopathogenic fungi
KW - phytopathogens
KW - phytopathology
KW - plant-pathogenic fungi
KW - United States of America
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Pests, Pathogens and Biogenic Diseases of Plants (FF600) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Agarose gel electrophoretic detection of six β-lactam antibiotic residues in milk.
AU - Cutting, J. H.
AU - Kiessling, W. M.
AU - Bond, F. L.
AU - McCarron, J. E.
AU - Kreuzer, K. S.
AU - Hurlbut, J. A.
AU - Sofos, J. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 3
SP - 663
EP - 667
SN - 1060-3271
AD - Cutting, J. H.: U.S. Food and Drug Administration, Denver District Laboratory, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19950404403. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9012-36-6, 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 80370-57-6, 61-72-3, 642-78-4. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - An electrophoretic method coupled with bioautography was developed for detection and identification of penicillin G, ampicillin, amoxicillin, cloxacillin, cephapirin and ceftiofur residues in milk. The method uses a 2% agarose gel for electrophoresis, an overlay of PM indicator agar seeded with Bacillus stearothermophilus var. calidolactis and incubation at 55°C for 16-18 h. The new method separated and detected residues in milk at the levels of concern for the FDA for penicillin G (5 ppb), cephapirin (20 ppb) and ceftiofur (50 ppb). The method also detected ampicillin, amoxicillin and cloxacillin at 20, 30 and 30 ppb respectively, but these levels are above those of concern for FDA (10 ppb).
KW - agarose
KW - amoxicillin
KW - ampicillin
KW - antibiotic residues
KW - antibiotics
KW - ceftiofur
KW - cephalosporins
KW - cloxacillin
KW - cows
KW - detection
KW - drug residues
KW - electrophoresis
KW - identification
KW - milk
KW - milk hygiene
KW - penicillins
KW - residues
KW - cattle
KW - Geobacillus stearothermophilus
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Geobacillus
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - amoxycillin
KW - Bacillus stearothermophilus var. calidolactis
KW - bacterium
KW - cephapirin
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative effectiveness of selective plating agars for recovery of Salmonella species from selected high-moisture foods.
AU - Sherrod, P. S.
AU - Amaguana, R. M.
AU - Andrews, W. H.
AU - June, G. A.
AU - Hammack, T. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 3
SP - 679
EP - 690
SN - 1060-3271
AD - Sherrod, P. S.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19951303163. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9002-18-0. Subject Subsets: Human Nutrition
N2 - The relative effectiveness of 6 selective plating media were compared for recovery of Salmonella spp. from selected high-moisture foods. Three new plating agars (EF-18, Rambach and xylose lysine Tergitol-4) and 3 selective plating agars (bismuth sulfite, Hektoen enteric, and xylose lysine desoxycholate) recommended by AOAC International and the Bacteriological Analytical Manual (BAM) were compared. The agars were streaked from cultures selectively enriched in selenite cystine broth, tetrathionate broth, and Rappaport-Vassiliadis medium. The high-moisture foods studied were naturally contaminated pork sausage, chicken parts, turkey parts, and frog legs and artifically contaminated shrimp, oysters, egg yolks, and lettuce. The relative effectiveness of each selective plating agar was determined by recovery of Salmonella spp. and enumeration of false-positive and false-negative reactions. Although the new selective plating agars compared favourably with the AOAC/BAM-recommended agars, they offered no advantage. Incubation of selective enrichment broths at elevated temp. decreased the numbers of false-positive and false-negative reactions for all 6 selective plating agars.
KW - agar
KW - biodeterioration
KW - culture media
KW - foods
KW - oysters
KW - plate count
KW - recovery
KW - species
KW - techniques
KW - salmonella
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunoaffinity column coupled with liquid chromatography for determination of fumonisin B1 in canned and frozen sweet corn.
AU - Trucksess, M. W.
AU - Stack, M. E.
AU - Allen, S.
AU - Barrion, N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 3
SP - 705
EP - 710
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 19951202226. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition; Horticultural Science; Medical & Veterinary Mycology; Maize
N2 - A modified liquid chromatographic (LC) method for determining fumonisin B1 (FB1) in maize was applied to canned and frozen sweetcorn. The sweetcorn was extracted with methanol-water (8+2) and the extract was filtered. The filtrate was diluted with water and passed through an immunoaffinity column. After the column was washed with water, FB1 was eluted with methanol-water (8+2). The eluate was evaporated to dryness using a vacuum concentrator and the residue was dissolved in acetonitrile-water (1+1). FB1 was derivatized with o-phthaldialdehyde. The derivative was separated on a reversed-phase C18 LC column using acetonitrile-water-acetic acid (50+50+1) and quantitated with a fluorescence detector. Recoveries of FB1 from canned and frozen sweetcorn spiked over the range of 50-200 ng/g were 76-88%. The limit of determination was approx. 25 ng/g and the limit of detection was approx. 4 ng/g. The method was applied to 97 commercial canned and frozen sweetcorn samples collected from different areas of the USA. 60 samples contained no FB1. Low levels of FB1 (trace-82 ng/g sweetcorn) were found in 35 samples; 235 ng/g FB1 was found in 1 canned sweetcorn sample and 350 ng/g FB1 was found in 1 frozen sweetcorn sample.
KW - analytical methods
KW - contamination
KW - estimation
KW - fumonisins
KW - liquid chromatography
KW - maize
KW - mycotoxins
KW - sweetcorn
KW - USA
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - corn
KW - fungal toxins
KW - immunoaffinity chromatography
KW - United States of America
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary intakes of pesticides, selected elements, and other chemicals: FDA total diet study, June 1984-April 1986.
AU - Gunderson, E. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 910
EP - 921
SN - 1060-3271
AD - Gunderson, E. L.: U.S. Food and Drug Administration, Office of Plant and Dairy Foods and Beverages, Division of Programs and Enforcement Policy, Washington, DC 20204, USA.
N1 - Accession Number: 19951412070. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration conducts the Total Diet Study to evaluate dietary intakes of selected pesticides, industrial chemicals and elements (including radionuclides). The results reported here reflect the sampling period from June 1984 to April 1986. The study involves retail purchase of foods representative of the total diet of the US population, preparation for table-ready consumption, and individual analyses of 234 items depicting the diets of 8 population groups. The diets were based on 2 nationwide food consumption surveys. The data presented represent 8 food collections (also termed "market baskets") in regional metropolitan areas during the 2-year period. Dietary intakes of over 90 analytes are presented for the 8 population groups, which range from infants to elderly adults. Intakes of selected population groups are compared with representative previous findings. As reported previously, average daily intakes are well below acceptable limits.
KW - diet studies
KW - intake
KW - pesticide residues
KW - radionuclides
KW - residues
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - Diet Studies (VV110)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - U.S. food and drug administration pesticide program: incidence/level monitoring of domestic and imported pears and tomatoes.
AU - Roy, R. R.
AU - Albert, R. H.
AU - Wilson, P.
AU - Laski, R. R.
AU - Roberts, J. I.
AU - Hoffmann, T. J.
AU - Bong, R. L.
AU - Bohannon, B. O.
AU - Yess, N. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 930
EP - 940
SN - 1060-3271
AD - Roy, R. R.: U.S. Food and Drug Administration, Office of Field Programs, Division of Field Program Planning and Evaluation, Washington, DC 20204, USA.
N1 - Accession Number: 19951412072. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 10265-92-6, 148-79-8. Subject Subsets: Horticultural Science; Human Nutrition; Postharvest Research; Agricultural Entomology
N2 - In 1992-1993, the US Food and Drug Administration (FDA) conducted a statistically based study of pesticide residues in domestic and imported pears and tomatoes. For pears, 710 domestic and 949 imported samples were collected and analysed; 79% of the domestic and 72% of the imported samples had detectable residues. Thiabendazole, a fungicide with postharvest uses, was found with greatest frequency in both groups of pears. 4 domestic and 12 imported samples contained violative residues, mainly of pesticides for which there are no US tolerances on pears. The statistically weighted (by shipment size) violation rates for domestic and imported pears were 1.0 and 0.9%, respectively. For tomatoes, 1219 domestic and 144 imported samples were collected and analysed; 84% of the domestic and 91% of the imported samples had detectable residues. Methamidophos, an insecticide, had the greatest frequency of occurrence in both groups of tomatoes. 33 domestic and 5 imported samples were violative, nearly all the result of acephate use, for which there is no US tolerance on tomatoes. The statistically weighted violation rates for domestic and imported tomatoes were 1.9 and 7.0%, respectively. The statistically weighted violation rates calculated for domestic and imported pears and domestic tomatoes in this study were lower than those observed under FDA's regulatory monitoring in recent years. The violation rate for imported tomatoes were somewhat higher under statistical monitoring than under regulatory monitoring. The results of the statistically based study show that, as in regulatory monitoring, the levels of pesticide residues found are generally well below US tolerances.
KW - agricultural entomology
KW - assessment
KW - commodities
KW - food contamination
KW - food legislation
KW - foods
KW - insecticide residues
KW - insecticides
KW - methamidophos
KW - pears
KW - pesticide residues
KW - pesticides
KW - residues
KW - stored products
KW - thiabendazole
KW - tomatoes
KW - USA
KW - Pyrus
KW - Pyrus communis
KW - Solanum
KW - Solanum lycopersicum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - Pyrus
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - Lycopersicon
KW - Lycopersicon esculentum
KW - pear
KW - TBZ
KW - tiabendazole
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Laws and Regulations (DD500)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of ajmalicine in reserpine raw materials by liquid chromatography with fluorescence detection.
AU - Cieri, U. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 944
EP - 945
SN - 1060-3271
AD - Cieri, U. R.: U.S. Food and Drug Administration, Philadelphia, PA 19106, USA.
N1 - Accession Number: 19960303734. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 50-55-5. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - A liquid chromatographic method is presented for the determination of ajmalicine in reserpine raw materials (usually obtained from the roots of Rauwolfia serpentina [Rauvolfia serpentina]). The sample was dissolved in a very small volume of chloroform, and the resulting solution was diluted with methanol. The reference solution of ajmalicine was prepared directly in methanol. The mobile phase was methanol containing a small volume of an aqueous solution of 1-pentanesulfonic acid, sodium salt. Detection was by fluorescence with excitation at 280 nm and emission at 360 nm.
KW - analytical methods
KW - chromatography
KW - detection
KW - determination
KW - fluorescence
KW - indole alkaloids
KW - liquid chromatography
KW - medicinal plants
KW - plant composition
KW - raw materials
KW - reserpine
KW - roots
KW - Apocynaceae
KW - Rauvolfia serpentina
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rauvolfia
KW - Apocynaceae
KW - analytical techniques
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Plant Composition (FF040)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of flunixin in milk by liquid chromatography with confirmation by gas chromatography/mass spectrometry and selected ion monitoring.
AU - Rupp, H. S.
AU - Holland, D. C.
AU - Munns, R. K.
AU - Turnipseed, S. B.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 959
EP - 967
SN - 1060-3271
AD - Rupp, H. S.: U.S. Food and Drug Administration, Animal Drugs Research Center, DEN-DO, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19950405720. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 38677-85-9. Subject Subsets: Human Nutrition; Dairy Science
N2 - A liquid chromatographic (LC) method was developed for the determination of flunixin (FNX) in bovine raw milk. The milk was acidified and mixed with silica gel, and the mixture was packed into a chromatographic column. The column was defatted with water-saturated dichloromethane-hexane (30 + 70, v/v), and the analyte was eluted with EtOAc. The EtOAc extract was washed with water at pH 3.5, the water was discarded, and the EtOAc layer was then extracted with 0.1M NaOH. The aqueous layer was drained, passed through a primed C18 solid-phase extraction (SPE) column and eluted with EtOAc. The EtOAc layer was dried under N2, taken up in a solution of MeOH-(5 mM tetrabutylammonium [TBA]-H2PO4 + 2 mM NaOH) (50 + 50), sonicated and filtered. FNX was determined by LC using a C18 column (ODS Hypersil), a mobile-phase mixture of 58% A (MeOH) and 42% B (5 mM TBA-H2PO4 + 2 mM NaOH), and a diode-array ultraviolet detector at 285 nm. FNX was determined in raw milk at 5 spiking levels (5, 10, 20, 40 and 80 ng drug/ml milk). Absolute recoveries ranged from 69.6 to 74.4%, and relative s.d. ranged from 1.1 to 6.9%. The limit of quantitations was 1.7 ng drug/ml milk. A lactating cow was dosed intravenously (2.2 mg/kg) with flunixin meglumine (Banamine) to generate incurred milk residues. FNX residues ranged from 7.34 ng/ml at 16 h postdose to 1.74 ng/ml at 24 h postdose. Both levels were obtained with additional β-glucuronidase treatment (almost no incurred drug was detected at these low levels without the enzyme treatment). The presence of FNX in incurred milk was confirmed by gas chromatography/mass spectrometry with selected ion monitoring.
KW - antiinflammatory agents
KW - chromatography
KW - determination
KW - drug residues
KW - drugs
KW - flunixin
KW - gas chromatography
KW - liquid chromatography
KW - mass spectrometry
KW - monitoring
KW - raw milk
KW - spectrometry
KW - medicines
KW - pharmaceuticals
KW - surveillance systems
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic/mass spectrometric confirmation of leucomalachite green in catfish (Ictalurus punctatus) tissue.
AU - Turnipseed, S. B.
AU - Roybal, J. E.
AU - Hurlbut, J. A.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 971
EP - 977
SN - 1060-3271
AD - Turnipseed, S. B.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19951202807. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 569-64-2. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology
N2 - A gas chromatography/mass spectrometry (GC/MS) method was developed to confirm the presence of leucomalachite green (LMG), a metabolite of the triphenylmethane dye malachite green (MG), in catfish tissue. Residues were isolated according to a previously described LC/VIS spectrometric analysis of MG and LMG in fish. In the isolation procedure, analytes were extracted from tissue with acetonitrile-buffer, partitioned into CH2Cl2 and applied to neutral alumina and propylsulfonic acid solid-phase extraction cartridges. Before GC/MS analysis, extracts prepared for the LC determinative method were eluted from a cyano solid-phase extraction cartridge, extracted into organic solvent and concentrated for GC/MS analysis. Selected ion monitoring was performed using 5 diagnostic ions (m/z 330, 329, 253, 210 and 165) of LMG. The method was validated by confirming LMG in tissue fortified with mixtures of MG and LMG (5 and 10 ng/g each) and in tissue from fish that had been exposed to low levels of MG.
KW - antifungal agents
KW - detection
KW - drug residues
KW - gas chromatography
KW - malachite green
KW - mass spectrometry
KW - tissues
KW - fishes
KW - Ictalurus
KW - Ictalurus punctatus
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - Ictalurus
KW - fungistats
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multivessel supercritical fluid extraction of food items in total diet study.
AU - Hopper, M. L.
AU - King, J. W.
AU - Johnson, J. H.
AU - Serino, A. A.
AU - Butler, R. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 4
SP - 1072
EP - 1079
SN - 1060-3271
AD - Hopper, M. L.: U.S. Food and Drug Administration, Total Diet Research Center, PO Box 15905, Lenexa, KS 66285-5905, USA.
N1 - Accession Number: 19951412076. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - foods
KW - pesticide residues
KW - analytical techniques
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of sulfadiazine in salmon by postcolumn derivatization and fluorescence detection.
AU - Gehring, T. A.
AU - Rushing, L. G.
AU - Thompson, H. C., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 5
SP - 1161
EP - 1164
SN - 1060-3271
AD - Gehring, T. A.: U.S. Food and Drug Administration, National Center for Toxicological Research, Office of Research, Division of Chemistry, Jefferson, AR 72079, USA.
N1 - Accession Number: 19962210316. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 68-35-9. Subject Subsets: Veterinary Science; Veterinary Science
N2 - A reversed-phase (ODS-2) liquid chromatographic method was developed to determine low nanogram-per-gram levels of sulfadiazine (SDZ) in salmon muscle tissue. SDZ was extracted with acetonitrile-aqueous 2% acetic acid (pH 3.0), partitioned into methylene chloride, and cleaned up by using a strong-cation-exchange, solid-phase extraction cartridge. SDZ was derivatized postcolumn with fluorescamine and detected by fluorescence. The limit of detection was 0.2 ng SDZ/g tissue. Recoveries from coho salmon tissue fortified with 1, 5, 10, and 20 ng SDZ/g tissue averaged 84.5, 85.0, 83.6, and 83.9%, respectively; recoveries from Atlantic salmon tissue fortified with 10 ng SDZ/g tissue averaged 82.6%.
KW - assays
KW - detection
KW - determination
KW - drug residues
KW - fluorescence
KW - liquid chromatography
KW - sulfadiazine
KW - sulfonamides
KW - Atlantic salmon
KW - salmon
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - diadromous fishes
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Salmo salar
KW - sulphadiazine
KW - sulphonamides
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962210316&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic determination of yohimbine in commercial yohimbe products.
AU - Betz, J. M.
AU - White, K. D.
AU - Marderosian, A. H. der
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 5
SP - 1189
EP - 1194
SN - 1060-3271
AD - Betz, J. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St, Washington, DC 20204, USA.
N1 - Accession Number: 19960305102. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 146-48-5. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Human Nutrition; Forestry
N2 - The bark of Pausinystalia yohimbe [P. johimbe], has recently been promoted in the United States as a dietary supplement alternative to anabolic steroids for the enhancement of athletic performance. As the number of yohimbe products on the retail market has increased, concerns about their safety have been raised because of the reported toxicity of yohimbine (the major alkaloid of the plant). Although plant materials can often be identified microscopically, they could not be identified by this means in many of the products, because the products were mixtures of various botanicals or were bark extracts and contained little or no plant material. A method for the extraction and capillary GC separation of the alkaloids of P. yohimbe was developed and used to analyse a number of commercial yohimbe products. The method involved solvent extraction and partitioning in chloroform-water followed by separation on a methyl silicone capillary GC column (N-P detection). Comparisons of chromatograms of extracts of authentic bark with those of commercial products indicated that although many products contained measurable quantities of the alkaloid yohimbine, they were largely devoid of the other alkaloids previously reported in this species. Concentrations of yohimbine in the commercial products ranged from <0.1 to 489 p.p.m., compared with 7089 p.p.m. in the authentic material. Authentic bark has been reported to contain up to 6% total alkaloids, 10-15% of which are yohimbine. The possible presence of undeclared diluents in the products was indicated by peaks in product chromatograms but not in those of authentic bark.
KW - alkaloids
KW - analytical methods
KW - bark
KW - chemical composition
KW - composition
KW - determination
KW - food supplements
KW - gas chromatography
KW - indole alkaloids
KW - medicinal plants
KW - medicinal properties
KW - plant composition
KW - quality
KW - quantitative analysis
KW - yohimbine
KW - USA
KW - man
KW - Rubiaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - chemical constituents of plants
KW - drug plants
KW - herbal products
KW - medicinal herbs
KW - officinal plants
KW - Pausinystalia johimbe
KW - United States of America
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Non-wood Forest Products (KK540)
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA total diet study, July 1986-April 1991, dietary intakes of pesticides, selected elements, and other chemicals.
AU - Gunderson, E. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 6
SP - 1353
EP - 1363
SN - 1060-3271
AD - Gunderson, E. L.: US Food and Drug Administration, Office of Plant and Dairy Foods and Beverages, Division of Programs and Enforcement Policy, Washington, DC 20204, USA.
N1 - Accession Number: 19961402204. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration conducts the Total Diet Study to estimate dietary intakes of selected pesticides, industrial chemicals and elements (including radionuclides). This paper reports results for the sampling period July 1986 to April 1991. The study involves retail purchase of foods representative of the "total diet" of the US population, preparation for "table-ready" consumption and individual analyses of 234 items making up the diets of 8 population groups. The diets were based on 2 nationwide food consumption surveys. The data presented represent 21 food collections (also termed "market baskets") in regional metropolitan areas during the 5-year period. Dietary intakes of nearly 120 analyses are presented for 8 population groups, which range from infants to elderly adults. Intakes of selected population groups are compared with representative findings from earlier Total Diet Study sampling periods. As reported previously, average daily intakes are well below acceptable limits.
KW - chemicals
KW - diet
KW - diet studies
KW - elements
KW - intake
KW - pesticide residues
KW - radionuclides
KW - residues
KW - trace elements
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - microelements
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of chromium and molybdenum in medical foods by graphite furnace atomic absorption spectrophotometry.
AU - Phifer, E. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1995///
VL - 78
IS - 6
SP - 1497
EP - 1501
SN - 1060-3271
AD - Phifer, E. C.: US Food and Drug Administration, Atlanta Center for Nutrient Analysis, Atlanta, GA 30309, USA.
N1 - Accession Number: 19961402213. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7439-98-7, 7440-47-3. Subject Subsets: Human Nutrition
N2 - Graphite furnace atomic absorption spectrophotometry was used to estimate chromium and molybdenum in 7 medical foods from 5 manufacturers. Linear standard curves were obtained for both elements for concentrations between 5 and 25 ng/ml. Detection limits were 0.24 for Cr and 0.67 ng/ml for Mo. Characteristic masses were 3.1 and 14.7 pg for Cr and Mo, respectively. No difference was detected between wet and dry ashing methods, and dry ashing was used to complete the study. The method was validated by assaying various National Institute of Standards and Technology standard reference materials. Analysis of these products for Cr and Mo were within certified values. 1 product was evaluated by this method for reproducibility (n=5). Relative standard deviations were 6.8 and 4.8% for Cr and Mo, respectively. This product contained Cr 0.31±0.02 and Mo 0.63±0.03 µg/g. The remaining products contained Cr 0.09-1.28 and Mo 0.07-2.3 µg/g. Mean recovery values were 98±14% (n=14) for Cr at spike levels of 0.20-1.89 µg/g and 102±24% (n=10) for Mo at spike levels of 0.30-1.89 µg/g.
KW - analytical methods
KW - atomic absorption spectrophotometry
KW - chromium
KW - enteral feeding
KW - estimation
KW - foods
KW - molybdenum
KW - solutions
KW - analytical techniques
KW - Mo
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402213&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Onchocerca volvulus: parasitologic and serologic responses in experimentally infected chimpanzees and mangabey monkeys.
AU - Eberhard, M. L.
AU - Dickerson, J. W.
AU - Tsang, V. C. W.
AU - Walker, E. M.
AU - Ottesen, E. A.
AU - Chandrashekar, R.
AU - Weil, G. J.
AU - Trpis, M.
AU - Strobert, E.
AU - Constantinidis, I.
AU - Swenson, R. B.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1995///
VL - 80
IS - 3
SP - 454
EP - 462
SN - 0014-4894
AD - Eberhard, M. L.: Division of Parasitic Diseases F13, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950807281. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Helminthology
N2 - Six chimpanzees (Pan troglodytes) and 6 mangabey monkeys (Cercocebus atys) were inoculated with Onchocerca volvulus 3rd-stage larvae (L3) of West African origin. Groups of 2 chimpanzees each received 200, 300 or 400 L3, and groups of 3 mangabeys each received either 50 or 250 L3. All 6 chimpanzees became microfilaria positive between 11 and 25 months pi, whereas 2 of the 6 mangabeys, one inoculated with 50 L3 and the other inoculated with 250 L3, were skin-snip positive at 24 and 37 months pi, respectively. All chimpanzees developed antibodies to 2 native antigens of 14 000 and 22 000 MW, and to the recombinant antigens OV16, OC3.6, and OC9.3. Marked antibody responses were observed in the mangabey monkeys, and in general, the responses were similar to those observed in the chimpanzees. However, in the mangabeys, these responses did not generally manifest themselves until later in the infection. It is suggested that in chimpanzees, the smallest inoculum used (200 L3) was sufficient to initiate consistent infections that had parasitological and immunological parameters equivalent to animals inoculated with large numbers of larvae. Similarly, inoculation of mangabey monkeys with small numbers of larvae appeared to be as likely to establish infection and induce immunological responses as did inoculation of large numbers of larvae. Microfilaria-positive chimpanzees and mangabey monkeys were examined by X ray, ultrasound and magnetic resonance imaging, but no adult worms or nodules were detected. The detection of antibodies directed against both native and recombinant antigens suggests that some of these responses might be useful for detecting early (prepatent) and occult infections.
KW - antigens
KW - disease models
KW - experimental infections
KW - helminths
KW - human diseases
KW - immune response
KW - parasites
KW - recombinant antigens
KW - Cercocebus
KW - chimpanzees
KW - Onchocerca volvulus
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pan
KW - Pongidae
KW - Onchocerca
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - antigenicity
KW - Cercocebus atys
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A new method for evaluating experimental cryptosporidial parasite loads using immunofluorescent flow cytometry.
AU - Arrowood, M. J.
AU - Hurd, M. R.
AU - Mead, J. R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1995///
VL - 81
IS - 3
SP - 404
EP - 409
SN - 0022-3395
AD - Arrowood, M. J.: Parasitic Diseases Branch, Division of Parasitic Diseases, National Centers for Infectious Diseases, Center for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19950807199. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Protozoology
N2 - A flow cytometric method for the quantification of Cryptosporidium parvum oocysts in stool specimens was developed to replace conventional microscopic immunofluorescent assays. Faecal pellets were collected from control (uninfected) severe combined immune-deficient mice, suspended in 2.5% potassium dichromate at a ratio of 400 µl per pellet, and homogenized by vortexing. Purified oocysts were added to the samples (105, 104, 10³, and 10²/ml). Aliquots (200 µl) of the vortexed samples were centrifuged over microscale discontinuous sucrose gradients. The oocyst-containing fractions were collected, washed, and incubated with an oocyst-specific monoclonal antibody (labelled with fluorescein isothiocyanate) for 30 minutes at 37°C. Sample volumes were adjusted to 600 µl with phosphate-buffered saline and assayed by using logical gating of forward/side scatter and fluorescence signal on a flow cytometer. Seeded samples showed a linear correlation with the number of oocysts recovered from the gradients. Analyses of stool samples from chronically infected mice demonstrated that the flow cytometry method was approximately 10 times more sensitive than conventional immunofluorescent assays.
KW - developmental stages
KW - experimental infections
KW - faeces
KW - flow cytometry
KW - immunocompromised hosts
KW - oocysts
KW - parasites
KW - scid mice
KW - techniques
KW - Cryptosporidium parvum
KW - mice
KW - protozoa
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - feces
KW - growth phase
KW - immunofluorescent flow cytometry
KW - quantification
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of intra- and interspecific Leishmania genetic polymorphisms by arbitrary primed polymerase chain reactions and use of polymorphic DNA to identify differentially regulated genes.
AU - Pogue, G. P.
AU - Koul, S.
AU - Lee, N. S.
AU - Dwyer, D. M.
AU - Nakhasi, H. L.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 1995///
VL - 81
IS - 4
SP - 282
EP - 290
SN - 0044-3255
AD - Pogue, G. P.: Laboratory of Molecular Pharmacology, Division of Hematologic Products, CBER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19950805357. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology
N2 - Arbitrary primed polymerase chain reactions (AP-PCR) were used to amplify different polymorphic genomic DNA fragments in Leishmania species. Using four 10-mer AP primers, geographic isolates of L. donovani and various Old World species of Leishmania were readily distinguished from one another by the pattern of amplified DNA products. Two important characteristics of AP-PCR were confirmed: the ability to amplify a consistent pattern of DNA fragments from the genomes of different isolates of a single species and the ability to identify genetic polymorphisms between the species isolates. Three polymorphic DNA fragments that differentiate L. donovani geographic isolates were selected for further analysis. Sequence analysis of the clones derived from these polymorphic fragments revealed 8 unique sequences. Six of 8 unique clones hybridized to distinct RNAs upon Northern blot analysis and 3 of these 6 clones hybridized to RNAs expressed differentially in in vitro-grown L. donovani pro- and amastigotes. One of the differentially expressed clones, LdE-6-1, exhibited restriction length polymorphisms that distinguished L. donovani from L. tropica and L. major. Comparative Northern blotting revealed that LdE-6-1 was differentially expressed in some members of the L. donovani species complex but not in L. major or L. tropica. The results demonstrate that AP-PCR can be used to generate products reflecting particular genes in organisms with low-complexity genomes.
KW - chemotaxonomy
KW - DNA
KW - DNA amplification
KW - genes
KW - genetic polymorphism
KW - molecular genetics
KW - northern blotting
KW - parasites
KW - polymerase chain reaction
KW - species
KW - Leishmania
KW - protozoa
KW - Sarcomastigophora
KW - Trypanosomatidae
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - biochemical taxonomy
KW - deoxyribonucleic acid
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serum-free culturing of adult Schistosoma mansoni in dialysis bags for the production of excretory/secretory antigens.
AU - Call, J. L.
AU - Pilcher, J. B.
AU - Freeman, G. L., Jr.
AU - Tsang, V. C. W.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1995///
VL - 81
IS - 5
SP - 742
EP - 746
SN - 0022-3395
AD - Call, J. L.: Division of Parasitic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341-3724, USA.
N1 - Accession Number: 19960801651. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Helminthology
N2 - Antigenic excretory/secretory (E/S) products from Schistosoma mansoni are potentially important in the development of diagnostic assays used to detect circulating antigens in schistosomiasis. The E/S products to be used as antigen(s) for this development must, by necessity, be free of exogenous proteins. The ability to extend serum-free in vitro culture of adult worms is, therefore, essential. Adult worms were perfused from mice, washed in serum-free RPMI-1640 with antibiotics, and placed in sterile dialysis bags, molecular weight cut-off MW 10 000, at a concentration of 100 worms in 1 ml of serum-free, supplemented RPMI-1640. Each bag was then placed in a flask of supplemented RPMI-1640 with 10% fetal calf serum in a humidified incubator at 37 °C, 7% CO2. At days 1, 3, 5, 8, and 12, worms were collected; E/S culture medium was analysed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Worm survival rates were 85% after 1 day in culture, dropping gradually to 65% on day 8, and then to 38% on day 12. Silver stain for total protein and immunoblot exposed to positive human infection serum showed E/S culture media from days 3 and 5 having the least complex banding pattern. The quantitative specific activity of E/S, as measured by antigen-limiting Falcon assay screening test system-enzyme-linked immunosorbent assays against human infection serum, indicates E/S antigenicity closely follows the attrition of worms and, therefore, may be directed against the release of somatic antigens by dead worms. Culturing S. mansoni in dialysis tubing is useful in deriving E/S products.
KW - antigens
KW - culture techniques
KW - excretory secretory products
KW - helminths
KW - parasites
KW - schistosoma mansoni
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antigenicity
KW - immunogens
KW - parasitic worms
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Other Invertebrate Culture (Not Aquaculture) (LL030)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival and infectivity of Babesia in blood maintained at 25 C and 2-4 C.
AU - Eberhard, M. L.
AU - Walker, E. M.
AU - Steurer, F. J.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1995///
VL - 81
IS - 5
SP - 790
EP - 792
SN - 0022-3395
AD - Eberhard, M. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19960801730. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology
N2 - Babesia microti-infected blood was stored at room temperature (about 25 °C) or refrigerated (4 °C) for 30 days. To assess viability of the parasites after storage at these 2 temperatures, a 0.25-ml aliquot was inoculated into each of 2 hamsters in 2 separate experiments at days 3, 7, 10, 14, 17, 21, 25, and 30. Blood films were prepared and examined weekly for the presence of parasites from all hamsters. Of hamsters inoculated with blood held at room temperature, only those inoculated at day 3 became positive, whereas all 4 hamsters inoculated with refrigerated blood on day 17 became parasitaemic and 1 of 4 hamsters inoculated with blood held for 21 days became parasitaemic. These results indicate that under blood banking conditions, this intracellular protozoan parasite can remain infective and transfusion-acquired infection with this parasite could occur throughout most of the time that blood is normally stored.
KW - blood
KW - blood transfusion
KW - experimental infection
KW - infectivity
KW - laboratory animals
KW - parasites
KW - survival
KW - transmission
KW - babesia
KW - Babesia microti
KW - hamsters
KW - protozoa
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Babesia
KW - Cricetinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - blood banks
KW - experimental transmission
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801730&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of tadpoles and frogs as paratenic hosts in the life cycle of Dracunculus insignis (Nematoda: Dracunculoidea).
AU - Eberhard, M. L.
AU - Brandt, F. H.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1995///
VL - 81
IS - 5
SP - 792
EP - 793
SN - 0022-3395
AD - Eberhard, M. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19960801731. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Helminthology
N2 - The possibility exists that paratenic hosts play a role in the life cycle of various Dracunculus species. In the present study, it was established that tadpoles of 2 genera of frogs (Xenopus and Rana) were capable of ingesting copepods infected with third-stage larvae (L3) of Dracunculus insignis. Once ingested, the L3s migrated from the gut to the somatic tissues of the tadpoles. In Xenopus, the dracunculid larvae persisted through the metamorphosis of the tadpoles into adult frogs. These observations confirm the concept that paratenic hosts, such as tadpoles or frogs, may be important means of transporting infective larvae of Dracunculus species up the food chain and facilitate transmission to the definitive hosts.
KW - helminths
KW - life cycle
KW - life history
KW - parasites
KW - paratenic hosts
KW - dracunculus insignis
KW - frogs
KW - nematoda
KW - Rana
KW - Xenopus
KW - Dracunculus
KW - Dracunculidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anura
KW - Amphibia
KW - vertebrates
KW - Chordata
KW - Ranidae
KW - Pipidae
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960801731&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevated innate peripheral blood eosinophilia fails to augment irradiated cercarial vaccine-induced resistance to Schistosoma mansoni in IL-5 transgenic mice.
AU - Freeman, G. L., Jr.
AU - Tominaga, A.
AU - Takatsu, K.
AU - Secor, W. E.
AU - Colley, D. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1995///
VL - 81
IS - 6
SP - 1010
EP - 1011
SN - 0022-3395
AD - Freeman, G. L., Jr.: 4770 Buford Hwy NE, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
N1 - Accession Number: 19960803084. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Helminthology
N2 - Using the γ-irradiated cercariae (irr-cerc) model, interleukin (IL)-5 transgenic mice were vaccinated in parallel with background-matched controls (C3H/HeN) to examine whether innate eosinophilia contributes to increased protection from a challenge infection. Mean peripheral blood eosinophil (PBE) levels in IL-5 transgenic mice were 21 000 mm³, whereas in naive C3H/HeN mice this value was 240 mm³. In 3 separate experiments, both groups of vaccinated mice showed significant resistance to challenge infection. However, there was no significant difference in the percent worm reduction between transgenic IL-5 C3H mice (mean % protection = 44.3 ; range = 42-45%) and the control C3H/HeN mice (mean % protection = 51.7; range = 41.64%). The findings indicate that high levels of innate PBE due to constitutive production of IL-5 do not augment irr-cerc-stimulated immunity.
KW - eosinophilia
KW - eosinophils
KW - experimental infections
KW - genetically engineered organisms
KW - helminths
KW - immunization
KW - irradiated vaccines
KW - laboratory animals
KW - live vaccines
KW - parasites
KW - resistance
KW - transgenic animals
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - attenuated vaccines
KW - eosinophil leukocytes
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GMOs
KW - immune sensitization
KW - parasitic worms
KW - Strigeida
KW - transgenic organisms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803084&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating food fortification options: general principles revisited with folic acid.
AU - Crane, N. T.
AU - Wilson, D. B.
AU - Cook, D. A.
AU - Lewis, C. J.
AU - Yetley, E. A.
AU - Rader, J. I.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995///
VL - 85
IS - 5
SP - 660
EP - 666
SN - 0090-0036
AD - Crane, N. T.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19961406012. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts; Maize
N2 - Folic acid is used as an example to illustrate some of the complex issues and general principles that emerge when evaluating fortification of the food supply as one possible means to address a public health recommendation. Distribution of current US daily folate intakes from conventional foods and dietary supplements were estimated. Intakes that might result from fortification of cereal-grain products and ready-to-eat cereals at various concentrations for 8 age/gender groups were estimated using the US Department of Agriculture's 1987-1988 Nationwide Food Consumption Survey. Results indicate that fortification of the general population's food supply tends to increase the folate intakes of consumers with high folate intakes more than it increases the intake of those with low folate intakes (the target population; women of childbearing age). The effectiveness of food fortification options for a target population and the safety for the general population impose conflicting challenges that must be considered concurrently when making decisions about fortifying the US food supply.
KW - breakfast cereals
KW - cereals
KW - congenital abnormalities
KW - folic acid
KW - foods
KW - fortification
KW - intake
KW - nervous system
KW - public health
KW - safety
KW - supplements
KW - vitamins
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - folacin
KW - folate
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406012&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Surveillance for pesticide-related illness - lessons from California.
AU - Ordin, D. L.
AU - Fine, L. J.
T2 - American Journal of Public Health
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995///
VL - 85
IS - 6
SP - 762
EP - 763
SN - 0090-0036
AD - Ordin, D. L.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
N1 - Accession Number: 19960502999. Publication Type: Editorial. Language: English. Number of References: 8 ref.
KW - insecticides
KW - monitoring
KW - occupational hazards
KW - poisoning
KW - regulations
KW - risk
KW - safety at work
KW - surveillance
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - rules
KW - surveillance systems
KW - toxicosis
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960502999&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silicosis among gold miners: exposure-response analyses and risk assessment.
AU - Steenland, K.
AU - Brown, D.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995///
VL - 85
IS - 10
SP - 1372
EP - 1377
SN - 0090-0036
AD - Steenland, K.: National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, MS R13, Cincinnatti, OH 45226, USA.
N1 - Accession Number: 19962006130. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - This study sought to estimate the risk of silicosis by cumulative exposure-years in a cohort of miners in South Dakota, USA exposed to silica, as well as the lifetime risk of silicosis under the current USA Occupational Safety and Health Administration (OSHA) standard (0.09 mg/m³). In a cohort study of 3330 gold miners who worked at least 1 year underground from 1940 to 1965 (average 9 years) and were exposed to a median silica level of 0.05 mg/m³ (0.15 mg/m³ for those hired before 1930), 170 cases of silicosis were determined from either death certificates or 2 cross-sectional radiographic surveys. The risk of silicosis was less than 1% with a cumulative exposure under 0.5 mg/m³-years, increasing to 68% to 84% for the highest cumulative exposure category of more than 4 mg/m³-years. Cumulative exposure was the best predictor of disease, followed by duration of exposure and average exposure. After adjustment for competing risks of death, a 45-year exposure under the current OSHA standard would lead to a lifetime risk of silicosis of 35% to 47%. Almost 2 million US workers are currently exposed to silica. The authors conclude that their results add to a small but increasing body of literature that suggests that the current OSHA silica exposure level is unacceptably high.
KW - exposure
KW - gold miners
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - occupations
KW - silica
KW - silicosis
KW - North America
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006130&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of apple 18 and 31 kD allergens by microsequencing and evaluation of their content during storage and ripening.
AU - Hsieh LiShan
AU - Moos, M., Jr.
AU - Lin Yuan
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 1995///
VL - 96
IS - 6
SP - 960
EP - 970
SN - 0091-6749
AD - Hsieh LiShan: Laboratory of Immunobiochemistry, Division of Allergenic Products and Parasitology, Centre for Biologics Evaluation and Research, Food and Drug Administration, HFM-422 1401 Rockville Pike, Rockville, MD 20852-1441, USA.
N1 - Accession Number: 19971401648. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Horticultural Science; Human Nutrition; Postharvest Research
N2 - The appearance of the 18 and 31 kDa apple allergens among different varieties of apple (Red Delicious, Golden Delicious, McIntosh and Granny Smith) and the change in the concentrations of the allergens during storage and after canning were investigated. Sera from 34 subjects allergic to birch, elm, alder or oak pollens were tested with tree pollen and apple extracts by immunoblotting. 24 sera reacted to apple allergens, 75% reacted to the 31 kDa protein and 37.5% reacted to the 18 kDa protein. Reactions were also obtained for a 16, and a 13-14 kDa protein. Patients hypersensitive to the birch pollen allergen bet v 1 all reacted to the apple 18 kDa protein and those hypersensitive to bet v 2 reacted variably to the 13-14 kDa antigen. The amino acid sequence of the 18 and 31 kDa apple allergens showed that the 18 kDa protein shared 52% identity with bet v 1. In testing for degree of IgE reactivity with pooled sera, freshly picked Golden Delicious and Granny Smith apples had the highest concentrations of the 31 kDa allergen and Golden Delicious had the highest concentration of 18 kDa allergen. Apples stored at 4°C up to 86-130 days showed an increase in 18 and 31 kDa allergens. However, ripening under controlled atmosphere did not show any correlation between the ripening process and the concentration of antigens. The heating and canning process destroyed the allergens in Golden Delicious apples. It was concluded that the allergens may be induced by factors related to disease resistance.
KW - allergens
KW - amino acid sequences
KW - apples
KW - biochemistry
KW - canning
KW - composition
KW - food allergies
KW - pollen
KW - ripening
KW - storage
KW - Malus
KW - man
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - food hypersensitivity
KW - protein sequences
KW - Crop Produce (QQ050)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401648&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy, immunogenicity, safety, and use of live attenuated chickenpox vaccine.
AU - Krause, P. R.
AU - Klinman, D. M.
JO - Journal of Pediatrics
JF - Journal of Pediatrics
Y1 - 1995///
VL - 127
IS - 4
SP - 518
EP - 525
SN - 0022-3476
AD - Krause, P. R.: Laboratory of DNA Viruses, Divison of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 19962004321. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - This article reviews issues pertaining to the efficacy, immunogenicity, safety and use of Varicella Virus Vaccine Live (Varivax).
KW - human diseases
KW - immunization
KW - reviews
KW - vaccines
KW - varicella
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chicken pox
KW - immune sensitization
KW - varicella-zoster virus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004321&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Group A rotavirus G type prevalence in two regions of Hungary.
AU - Szücs, G.
AU - Matson, D. O.
AU - Új, M.
AU - Kukán, E.
AU - Mihály, I.
AU - Jelenik, Z.
AU - Estes, M. K.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 1995///
VL - 140
IS - 10
SP - 1693
EP - 1703
SN - 0304-8608
AD - Szücs, G.: Laboratory of Virology, County Institute of National Public Health Service, Pécs, Hungary.
N1 - Accession Number: 19962004125. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health
N2 - Rotaviruses are antigenically complex, with multiple serotypes (G types). The first longitudinal study of group A rotavirus serotype (G type) distribution in Hungary is reported. Neutralizing monoclonal antibodies specific for G1, G2, G3, and G4 were used in an enzyme immunoassay to determine the antigenic variation of group A rotaviruses in two collections of stool specimens assembled from 1984-1992 in Baranya County, southwest Hungary, and from 1988-1992 at the Central Hospital for Infectious Diseases in Budapest. Ninety-two percent of the 1215 virus-positive samples were typed as follows: G1 (81%), G2 (4%), G3 (1%), G4 (5%), or mixed type (1%). G1 was the predominant type during the entire study period with the exception of the 1988/1989 rotavirus season in Baranya County when G4 predominated. Among G1 strains, different electropherotypes were detected with a shift of the predominant G1 electropherotype(s) each 2 to 3 years. G typing from two longitudinal collections established regional differences within Hungary in the prevalence of rotavirus antigenic types among children with rotavirus-associated diarrhoea. These are the first longitudinal rotavirus typing results for Hungary and Central Europe.
KW - antigenic variation
KW - antigens
KW - children
KW - diarrhoea
KW - enzyme immunoassay
KW - faeces
KW - human diseases
KW - infections
KW - monoclonal antibodies
KW - strains
KW - Europe
KW - Hungary
KW - man
KW - rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - antigenic polymorphism
KW - antigenicity
KW - diarrhea
KW - feces
KW - immunogens
KW - scouring
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004125&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cardiovascular disease risk factors among American Indians. The Strong Heart Study.
AU - Welty, T. K.
AU - Lee, E. T.
AU - Yeh JeunLiang
AU - Cowan, L. D.
AU - Go, O.
AU - Fabsitz, R. R.
AU - Le Ngoc Anh
AU - Oopik, A. J.
AU - Robbins, D. C.
AU - Howard, B. V.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 1995///
VL - 142
IS - 3
SP - 269
EP - 287
SN - 0002-9262
AD - Welty, T. K.: Epidemiology Program, Aberdeen Area Indian Health Service, Rapid City, SD, USA.
N1 - Accession Number: 19962006557. Publication Type: Journal Article. Language: English. Number of References: 94 ref. Registry Number: 57-88-5. Subject Subsets: Public Health
N2 - The Strong Heart Study, a study of cardiovascular disease among American Indians, was conducted to determine cardiovascular disease rates and the prevalence of risk factors among members of 13 tribal groups in South Dakota/North Dakota (SD/ND), southeastern Oklahoma, and Arizona. From 1989 to 1992, 4549 tribal members aged 45-74 years (62% of eligible participants) were surveyed and examined for cardiovascular disease and its risk factors. Mean total cholesterol concentrations were over 20 mg/dl lower among the men and 27 mg/dl lower among the women than national mean levels for the same age groups. Cholesterol levels varied by tribal group; Arizona Indians had mean levels more than 20 mg/dl lower than those of SD/ND Indians. The prevalence of hypercholesterolemia was almost twice as high among SD/ND Indians as among Arizona Indians, but the rates for all three groups were much lower than total US rates (all races). Mean levels of high density lipoprotein cholesterol were lower among Indian men and women than in the US population as a whole. The prevalence of hypertension among Arizona and Oklahoma Indians was higher than that for the entire USA. SD/ND Indians had significantly lower mean blood pressures and prevalence rates of hypertension than Oklahoma and Arizona Indians and the USA as a whole. The prevalence of cigarette smoking was higher for all Indian groups except Arizona women in comparison with US rates. Smoking rates were highest in SD/ND and lowest in Arizona. Indian smokers smoked fewer cigarettes per day than the average US smoker. Arizona Indians had the highest prevalence of diabetes mellitus; over 60% of those participants were diabetic. In Oklahoma and SD/ND, one third of the men and over 40% of the women were diabetic. In addition, 13-20% of the participants had impaired glucose tolerance. Proteinuria was also a common problem; almost half of the Arizona Indians had micro- or macroalbuminuria, and 20% of Oklahoma and SD/ND Indians had significant proteinuria. The prevalence of obesity was high in all 3 groups, with Arizona Indians having the highest rates and the highest mean body mass indices. The prevalence of current alcohol use was lower among Indians than in the nation as a whole, but binge drinking was common among those who used alcohol. These results indicate that cardiovascular disease risk factors vary significantly among tribal groups. Prevention programs tailored toward decreasing the prevalence of risk factors are recommended for long-term reduction of cardiovascular disease rates in American Indian communities.
KW - alcohol intake
KW - American Indians
KW - cardiovascular diseases
KW - cholesterol
KW - diabetes mellitus
KW - human diseases
KW - lipoproteins
KW - obesity
KW - proteinuria
KW - risk factors
KW - tobacco smoking
KW - Arizona
KW - North America
KW - North Dakota
KW - Oklahoma
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Great Plains States of USA
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - alcohol consumption
KW - fatness
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of secular trends in CD4+ lymphocyte loss among human immunodeficiency virus type 1 (HIV-1)-infected men with known dates of seroconversion.
AU - O'Brien, T. R.
AU - Hoover, D. R.
AU - Rosenberg, P. S.
AU - Chen, B.
AU - Detels, R.
AU - Kingsley, L. A.
AU - Phair, J.
AU - Saah, A. J.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 1995///
VL - 142
IS - 6
SP - 636
EP - 642
SN - 0002-9262
AD - O'Brien, T. R.: Epidemiology and Biostatistics Program, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA.
N1 - Accession Number: 19962006265. Publication Type: Journal Article. Language: English. Number of References: 23 ref.
KW - disease course
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - men
KW - seroconversion
KW - serology
KW - t lymphocytes
KW - trends
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease progression
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - T cells
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006265&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV-1 infection alters monocyte interactions with human microvascular endothelial cells.
AU - Dhawan, S.
AU - Weeks, B. S.
AU - Soderland, C.
AU - Schnaper, H. W.
AU - Toro, L. A.
AU - Asthana, S. P.
AU - Hewlett, I. K.
AU - Stetler-Stevenson, W. G.
AU - Yamada, S. S.
AU - Yamada, K. M.
AU - Meltzer, M. S.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1995///
VL - 154
IS - 1
SP - 422
EP - 432
SN - 0022-1767
AD - Dhawan, S.: Division of Transfusion Transmitted Diseases (HFM-310), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 19952009089. Publication Type: Journal Article. Language: English. Number of References: 49 ref.
KW - endothelium
KW - human diseases
KW - interactions
KW - monocytes
KW - pathogenesis
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952009089&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA.
AU - Mor, G.
AU - Klinman, D. M.
AU - Shapiro, S.
AU - Hagiwara, E.
AU - Sedegah, M.
AU - Norman, J. A.
AU - Hoffman, S. L.
AU - Steinberg, A. D.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1995///
VL - 155
IS - 4
SP - 2039
EP - 2046
SN - 0022-1767
AD - Mor, G.: Section of Retroviral Immunology, Laboratory of Retrovirus Research, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, MD, 20892, USA.
N1 - Accession Number: 19960803237. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 308067-57-4, 9008-11-1. Subject Subsets: Protozoology
N2 - The number, type, and location of cytokine- and antibody-secreting cells activated in mice immunized and boosted with plasmid DNA encoding the circumsporozoite protein of the malarial parasite Plasmodium yoelii (PyCSP) were monitored. The initial humoral response was localized to the draining lymph nodes and was characterized by the production of IgG1 anti-PyCSP antibodies and the Th2 cytokine IL-4. In contrast, the secondary response was dominated by IFN-γ production and the secretion of IgG2a anti-PyCSP antibodies in the spleen. PyCSP DNA and mRNA were detected only in the quadriceps muscles (sites of plasmid injection), yet these sites lacked either cytokine- or antibody-secreting cells. These findings indicate that circulating lymphocytes encounter plasmid-encoded antigen in the muscle bed, initiate a humoral response in the draining lymph nodes, and then seed distal lymphoid organs. Profound differences were observed between the primary and secondary immune responses induced by plasmid immunization, which may influence vaccine efficacy.
KW - antibodies
KW - cytokines
KW - humoral immunity
KW - immune response
KW - immunoglobulins
KW - interferon
KW - parasites
KW - mice
KW - Plasmodium yoelii
KW - protozoa
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - circumsporozoite proteins
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803237&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of differentially expressed Leishmania donovani genes using arbitrarily primed polymerase chain reactions.
AU - Pogue, G. P.
AU - Lee, N. S.
AU - Koul, S.
AU - Dwyer, D. M.
AU - Nakhasi, H. L.
JO - Gene
JF - Gene
Y1 - 1995///
VL - 165
IS - 1
SP - 31
EP - 38
SN - 0378-1119
AD - Pogue, G. P.: Laboratory of Molecular Pharmacology, Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19960803732. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology
N2 - Arbitrarily primed polymerase chain reactions (AP-PCR) were used to amplify polymorphic DNA fragments from the genomes of a variety of geographic isolates of Leishmania donovani. Five polymorphic DNA fragments were cloned and sequence analysis identified 15 unique clones. Northern blot analysis showed that 13 of the 15 clones hybridized to transcribed RNAs isolated from L. donovani. Eight of these 13 AP-PCR clones specifically hybridized to L. donovani RNAs that were differentially expressed in promastigote and 'amastigote' cells. Comparative Northern analysis of four differentially expressed AP-PCR clones indicated that two clones, LdS-14-14 and LdI-9-7, were expressed in L. donovani and several other Leishmania species. However, RNAs corresponding to two other AP-PCR clones, LdE-6-1 and LdI-9-5, were detected only in members of the L. donovani complex, and not in L. major or L. tropica. Comparative Southern blot analysis of the LdS-14-14 locus revealed numerous restriction-fragment length polymorphisms (RFLP) distinguishing L. major and L. tropica from the L. donovani isolates and L. infantum. However, the LdS-14-14 loci were mapped to similar-sized chromosomes observed among all Old World Leishmania species tested, indicating that localized nucleotide divergence, not chromosomal rearrangement, was responsible for altered Southern blot patterns. These results demonstrate that AP-PCR is a very useful method for identifying expressed gene sequences in organisms of relatively low-complexity genomes.
KW - clones
KW - molecular genetics
KW - parasites
KW - polymerase chain reaction
KW - random amplified polymorphic DNA
KW - Leishmania donovani
KW - protozoa
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - PCR
KW - RAPD
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803732&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.
AU - Morris, S.
AU - Bai, G. H.
AU - Suffys, P.
AU - Portillo-Gomez, L.
AU - Fairchok, M.
AU - Rouse, D.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1995///
VL - 171
IS - 4
SP - 954
EP - 960
SN - 0022-1899
AD - Morris, S.: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 19952004929. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
KW - drug resistance
KW - human diseases
KW - molecular genetics
KW - multiple drug resistance
KW - mycobacterial diseases
KW - tuberculosis
KW - District of Columbia
KW - North America
KW - USA
KW - man
KW - mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - biochemical genetics
KW - mycobacterial infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004929&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human and viral interleukin-10 in acute Epstein-Barr virus-induced infectious mononucleosis.
AU - Taga, H.
AU - Taga, K.
AU - Wang, F.
AU - Chretien, J.
AU - Tosato, G.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1995///
VL - 171
IS - 5
SP - 1347
EP - 1350
SN - 0022-1899
AD - Taga, H.: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 19952004751. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 130068-27-8. Subject Subsets: Public Health
N2 - Human interleukin 10 (hIL-10), a product of monocytes, T cells, and B cells, shares extensive structural and functional similarity with viral IL-10 (vIL-10), a product of Epstein-Barr virus (EBV) replication. With 2 ELISAs, 1 that recognizes both hIL-10 and vIL-10 and the other specific for vIL-10, IL-10 was measured in serum or plasma and in saliva from 50 patients in the USA with acute EBV-induced infectious mononucleosis and from 19 normal subjects. In serum or plasma, 60% of the patients had measurable hIL-10 and/or vIL-10 and 18% had measurable vIL-10. In saliva, 20% of the patients had detectable hIL-10 and/or vIL-10 and none had detectable vIL-10. In contrast, hIL-10 and/or vIL-10 was undetectable in all 19 normal serum or plasma samples (P <0.001 vs. patient samples). Among normal saliva samples, 21% had detectable hIL-10 and/or vIL-10 but none had detectable vIL-10. Thus, most patients with acute EBV-induced infectious mononucleosis transiently have abnormally high levels of circulating IL-10.
KW - human diseases
KW - immune response
KW - infections
KW - infectious mononucleosis
KW - interleukin 10
KW - North America
KW - USA
KW - Human herpesvirus 4
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Lymphocryptovirus
KW - Gammaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human herpesvirus 4
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Epstein-Barr virus
KW - glandular fever
KW - immunity reactions
KW - immunological reactions
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004751&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monopalmitic acid-peptide conjugates induce cytotoxic T cell responses against malarial epitopes: importance of spacer amino acids.
AU - Verheul, A. F. M.
AU - Udhayakumar, V.
AU - Jue, D. L.
AU - Wohlhueter, R. M.
AU - Lal, A. A.
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 1995///
VL - 182
IS - 2
SP - 219
EP - 226
SN - 0022-1759
AD - Verheul, A. F. M.: Immunology Branch, Division of Parasitic Diseases, National Centers for Infectious Diseases, Centers for Disease Control & Preventive, Public Health Service, US Department of Health and Human Services, Mailstop F12, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19950808534. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology
N2 - The Plasmodium berghei circumsporozoite protein cytolytic T cells (CTL) epitope (SYIPSAEKI (PL76)) was used for these experiments. This peptide with cysteine-serine (CS) as spacer amino acids was coupled to palmitic acid (PA). The same CTL epitope containing only an extra serine was linked to S-[2,3-bis(palmitoyloxy)- (2-RS)-propyl]-N-palmitoyl-(R)-cysteine (tripam-C). Inbred mice [(BALB/c X C57BL/6)F1] were immunized intravenously with the lipopeptides. Both types of lipopeptides induced significant CTL responses after one injection. Immunization of the monopalmitic acid-peptide conjugate intraperitoneally emulsified in Freund's complete adjuvant also induced a significant CTL response, but the magnitude was lower as compared to the intravenous route. The major advantages of the use of the simple monopalmitic acid-peptide conjugates are: (i) low costs of the fatty acid; (ii) coupling of lipid to peptide can be performed using the peptide synthesizer during standard peptide synthesis, and (iii) standard peptide methodology can be used for purification. To investigate whether a spacer amino acid sequence between the actual CTL epitope and PA is required for induction of an optimal CTL response, a monopalmitic acid-peptide conjugates was prepared with different spacer amino acids. A lipopeptide without a spacer amino acid and another one containing the CS spacer sequence both induced a CTL response, whereas a lipopeptide with a serine as spacer failed to induce CTL. These results indicated that the amino acid spacer sequences influence the immunological properties of the palmitic acid-peptide conjugates.
KW - amino acids
KW - circumsporozoite protein
KW - immune response
KW - laboratory animals
KW - malaria
KW - parasites
KW - T lymphocytes
KW - mice
KW - Plasmodium berghei
KW - protozoa
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19950808534&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral.
AU - Obermeyer, W. R.
AU - Musser, S. M.
AU - Betz, J. M.
AU - Casey, R. E.
AU - Pohland, A. E.
AU - Page, S. W.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1995///
VL - 208
IS - 1
SP - 6
EP - 12
SN - 0037-9727
AD - Obermeyer, W. R.: Divisions of Natural Products and General Scientific Support, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19951405932. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - HPLC and mass spectrometric (MS) procedures were developed to estimate lignans in flaxseed (Linum usitatissimum) and chaparral (Larrea tridentata). Flaxseed contains high concentrations of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known oestrogenic compounds. Flaxseed and chaparral products have been marketed as dietary supplements. A mild enzyme hydrolysis procedure to prevent the formation of artifacts in the isolation step was used in the determination of secoisolariciresinol in flaxseed products. HPLC with ultraviolet spectral (UV) or MS detection was used as the determinative steps. HPLC procedures with UV detection and mass spectrometry were developed to characterize the phenolic components, including lignans and flavonoids, of chaparral and to direct fractionation studies for the bioassays.
KW - analytical methods
KW - chaparral
KW - flavonoids
KW - flax
KW - food supplements
KW - lignans
KW - linseed
KW - phenolic compounds
KW - plant oestrogens
KW - supplements
KW - Larrea tridentata
KW - Linum usitatissimum
KW - Larrea
KW - Zygophyllaceae
KW - Sapindales
KW - Geraniales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Linum
KW - Linaceae
KW - Linales
KW - analytical techniques
KW - phytoestrogens
KW - plant estrogens
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
KW - Plant Composition (FF040)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Faster evaluation of vital drugs.
AU - Kessler, D. A.
AU - Feiden, K. L.
JO - Scientific American
JF - Scientific American
Y1 - 1995///
VL - 272
IS - 3
SP - 26
EP - 32
SN - 0036-8733
AD - Kessler, D. A.: Food and Drug Administration, Washington, USA.
N1 - Accession Number: 19952004052. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 82410-32-0, 30516-87-1.
KW - acquired immune deficiency syndrome
KW - antiviral agents
KW - clinical trials
KW - drugs
KW - evaluation
KW - ganciclovir
KW - HIV infections
KW - licences
KW - regulation
KW - therapy
KW - treatment
KW - zidovudine
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - AZT
KW - human immunodeficiency virus infections
KW - licenses
KW - licensing
KW - medicines
KW - pharmaceuticals
KW - therapeutics
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004052&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Hepatitis C transmission associated with intravenous immunoglobulins.
AU - Yu, M. W.
AU - Mason, B. L.
AU - Guo, Z. P.
AU - Tankersley, D. L.
AU - Nedjar, S.
AU - Mitchell, F. D.
AU - Biswas, R. M.
T2 - Lancet (British edition)
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1995///
VL - 345
IS - 8958
SP - 1173
EP - 1174
SN - 0140-6736
AD - Yu, M. W.: Division of Hematology and Division of Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Adminstration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19952004430. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Registry Number: 308067-57-4. Subject Subsets: Public Health
KW - hepatitis C
KW - human diseases
KW - immunoglobulins
KW - transmission
KW - Maryland
KW - North America
KW - USA
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - gamma-globulins
KW - immune globulins
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952004430&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Carazolol.
AU - Livingston, R. C.
JO - FAO Food and Nutrition Paper
JF - FAO Food and Nutrition Paper
Y1 - 1995///
IS - 41/7
SP - 9
EP - 13
CY - Rome; Italy
PB - Food and Agriculture Organization (FAO)
SN - 0254-4725
AD - Livingston, R. C.: Center for Veterinary Medicine, FDA, Rockville, USA.
N1 - Accession Number: 19962206795. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Registry Number: 57775-29-8. Subject Subsets: Veterinary Science; Pig Science
KW - carazolol
KW - drug metabolism
KW - drug residues
KW - molecular conformation
KW - nomenclature
KW - pharmacokinetics
KW - pharmacology
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hogs
KW - swine
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962206795&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neomycin.
AU - Livingston, R. C.
JO - FAO Food and Nutrition Paper
JF - FAO Food and Nutrition Paper
Y1 - 1995///
IS - 41/7
SP - 57
EP - 67
CY - Rome; Italy
PB - Food and Agriculture Organization (FAO)
SN - 0254-4725
AD - Livingston, R. C.: Center for Veterinary Medicine, FDA, Rockville, USA.
N1 - Accession Number: 19962206800. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1404-04-2. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Pig Science
KW - chemical analysis
KW - drug metabolism
KW - drug residues
KW - milk
KW - molecular conformation
KW - neomycin
KW - nomenclature
KW - pharmacokinetics
KW - poultry
KW - residues
KW - cattle
KW - goats
KW - pigs
KW - rats
KW - sheep
KW - turkeys
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Capra
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Muridae
KW - rodents
KW - Ovis
KW - Meleagris
KW - Phasianidae
KW - Galliformes
KW - birds
KW - domesticated birds
KW - hogs
KW - swine
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962206800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Logging safety in forest management education.
AU - Fosbroke, D. E.
AU - Myers, J. R.
A2 - Gottschalk, K. W.
A2 - Fosbroke, S. L. C.
JO - General Technical Report - Northeastern Forest Experiment Station, USDA Forest Service
JF - General Technical Report - Northeastern Forest Experiment Station, USDA Forest Service
Y1 - 1995///
IS - NE-197
SP - 442
EP - 453
CY - Radnor, Pennsylvania; USA
AD - Fosbroke, D. E.: National Institute for Occupational Safety and Health, Division of Safety Research, M/S P-180 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19970609088. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 + 17 ref.
N2 - Forest management degree programmes in the USA prepare students for careers in forestry by teaching a combination of biological sciences and business management, but little consideration is given to worker safety and health, and its effects on forest management. This paper illustrates the ethical and economic importance of logging safety to forest managers and advocates incorporating safety issues into existing forestry courses. An appendix gives examples of health and safety information that could be integrated into forest policy and forest economics courses.
KW - education
KW - forest management
KW - forestry workers
KW - forests
KW - logging
KW - occupational health
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Central Hardwood Forest Conference
KW - occupational safety
KW - timber extraction
KW - timber harvesting
KW - United States of America
KW - Forest Mensuration and Management (KK120) (Discontinued March 2000)
KW - Wood Properties, Damage and Preservation (KK510)
KW - Education, Extension, Information and Training (General) (CC000)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970609088&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Forest management practices and the Occupational Safety and Health Administration logging standard.
AU - Myers, J. R.
AU - Fosbroke, D. E.
A2 - Gottschalk, K. W.
A2 - Fosbroke, S. L. C.
JO - General Technical Report - Northeastern Forest Experiment Station, USDA Forest Service
JF - General Technical Report - Northeastern Forest Experiment Station, USDA Forest Service
Y1 - 1995///
IS - NE-197
SP - 454
EP - 462
CY - Radnor, Pennsylvania; USA
AD - Myers, J. R.: National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 19970609089. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 23 ref.
N2 - The US Occupation Safety and Health Administration (OSHA) has established regulations that have been extended (from January 1995) from pulpwood harvesting to include sawtimber harvest operations. Because logging is a major tool used by forest managers to meet silvicultural goals, managers must be aware of what the OSHA standard means to them. Many aspects of the new standard pertain to the training of logging employees, safe equipment operation, and safe harvesting techniques, but there are sections that affect forest management practices, especially for hardwood forests, in the same way as environmental regulations. There is the potential for forest management practices to influence the safety of logging operations by considering how the stand will be harvested when selecting silvicultural treatments. Forest managers will also be responsible for balancing conflicts between environmental issues and OSHA regulations, such as the removal of hazardous trees from a stand, placement of skid trails, and where to initiate logging. These and other issues are discussed to give forest managers a better appreciation of their role in making logging a safer industry.
KW - forest management
KW - forestry workers
KW - forests
KW - logging
KW - regulations
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Central Hardwood Forest Conference
KW - occupational safety
KW - rules
KW - timber extraction
KW - timber harvesting
KW - United States of America
KW - Forest Mensuration and Management (KK120) (Discontinued March 2000)
KW - Wood Properties, Damage and Preservation (KK510)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970609089&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulatory perspectives on the use and misuse of antimicrobial drugs in milk production.
AU - O'Rangers, J. J.
T2 - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
JO - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
JF - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
Y1 - 1995///
SP - 123
EP - 130
CY - Brussels; Belgium
PB - International Dairy Federation
SN - 9290980214
AD - O'Rangers, J. J.: US Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Pl, Rockville, MD 20855, USA.
N1 - Accession Number: 19960401732. Publication Type: Conference paper. Language: English. Subject Subsets: Veterinary Science; Dairy Science
N2 - The FDA's compliance policy of 'extra-label' use of drugs legalizes the use, by veterinarians, of an approved animal drug in a manner not conforming with the specification on the label of the drug. Specifications of the policy, and the evaluation strategy for 82 drugs known or suspected of use in dairy practice in the USA are discussed, and the 82 drugs and their status are listed in descending order of residue concern.
KW - antibiotic residues
KW - antibiotics
KW - antiinfective agents
KW - dairy farms
KW - drug residues
KW - drug therapy
KW - drugs
KW - legislation
KW - milk
KW - milk hygiene
KW - milk production
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antimicrobials
KW - chemotherapy
KW - medicines
KW - pharmaceuticals
KW - Residues of antimicrobial drugs and other inhibitors in milk
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Dairy Animals (LL110)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960401732&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Pesticide residues in food - what is out there?
AU - Genova, L.
A2 - Neal, J.C.
T2 - Proceedings of the forty-ninth annual meeting of the Northeastern Weed Science Society, Boston, Massachusetts, USA, 2-5 January 1995.
JO - Proceedings of the forty-ninth annual meeting of the Northeastern Weed Science Society, Boston, Massachusetts, USA, 2-5 January 1995.
JF - Proceedings of the forty-ninth annual meeting of the Northeastern Weed Science Society, Boston, Massachusetts, USA, 2-5 January 1995.
Y1 - 1995///
SP - 166
EP - 169
CY - Geneva, New York; USA
PB - Northeastern Weed Science Society
AD - Genova, L.: Food and Drug Administration, Baltimore, Massachusetts, USA.
N1 - Accession Number: 19952305861. Publication Type: Conference paper. Language: English. Subject Subsets: Weeds; Human Nutrition; Agricultural Entomology
N2 - The occurrence of pesticide residues in food is discussed, including results of the 1992 pesticide residue monitoring programme during which the incidence and level of pesticide residues in food (including infant foods) were investigated. The circle of poison concept (i.e. that involving banned pesticides made in the USA which are exported abroad where they are used on crops which are subsequently imported back into the USA) is also mentioned.
KW - agricultural entomology
KW - exports
KW - foods
KW - herbicide residues
KW - herbicides
KW - imports
KW - infant foods
KW - insecticide residues
KW - insecticides
KW - legislation
KW - nontarget effects
KW - pesticide residues
KW - pesticides
KW - residues
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - Northeastern Weed Science Society
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19952305861&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - National Drug Residue Milk Monitoring Program.
AU - Maturin, L. J.
T2 - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
JO - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
JF - Symposium on residues of antimicrobial drugs and other inhibitors in milk. Kiel, Germany, 28-31 August 1995.
Y1 - 1995///
SP - 319
EP - 323
CY - Brussels; Belgium
PB - International Dairy Federation
SN - 9290980214
AD - Maturin, L. J.: US Food and Drug Administration, 6502 South Archer Road, Summit Argo, Illinois 60501-1933, USA.
N1 - Accession Number: 19960401778. Publication Type: Conference paper. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science
N2 - The structure and functions of the Program, which was initiated in the USA in February 1991, are discussed. Tests used for analysis of the various groups of drugs, their limit of detection and safe tolerance levels, are summarized.
KW - analytical methods
KW - antibiotic residues
KW - detection
KW - drug residues
KW - drugs
KW - milk
KW - milk hygiene
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - Residues of antimicrobial drugs and other inhibitors in milk
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960401778&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunochemical properties of a polysaccharide antigen of Trichosporon beigelii that cross-reacts with the capsular glucuronoxylomannan of Cryptococcus neoformans.
AU - Devi, S. J. N.
AU - Reddy, P. G.
AU - Lyman, C. A.
AU - Walsh, T. J.
AU - Frasch, C. E.
AU - Bush, A. C.
JO - Immunology and Infectious Diseases
JF - Immunology and Infectious Diseases
Y1 - 1996///
VL - 6
IS - 2
SP - 87
EP - 92
SN - 0959-4957
AD - Devi, S. J. N.: Division of Bacterial Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19961201578. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The isolation and purification of the cross-reactive polysaccharide antigen from T. beigelii, str. TCM, are described. Immunochemical characterization of this carbohydrate antigen revealed that it shares antigenic determinant(s) with the capsular glucuronoxylomannan (GXM) of C. neoformans. It was a cell-associated, high MW acidic polysaccharide which was released into the culture medium during growth in vitro. T. beigelii released 96-fold less polysaccharide into the culture supernatant than a clinical isolate of C. neoformans. Qualitative chemical analysis as determined by high-performance anion-exchange chromatography revealed that the polysaccharide was composed of mannose, xylose, glucose and glucuronic acid. Nuclear magnetic resonance spectroscopy of native and modified polysaccharides suggested the presence of O-acetyl groups. The presence of O-acetyl and glucuronyl epitopes was confirmed serologically using epitope-specific antibodies. T. beigelii polysaccharide produced a precipitation line of partial identity with cryptococcal anti-GXM serum by immunodiffusion. It is concluded that the cell-associated carbohydrate antigen of T. beigelii is immunochemically similar to the GXM of C. neoformans and may play a role in pathogenesis.
KW - antigens
KW - carbohydrates
KW - cross reaction
KW - epitopes
KW - immunochemistry
KW - immunology
KW - polysaccharides
KW - purification
KW - Cryptococcus neoformans
KW - Trichosporon beigelii
KW - Cryptococcus (Fungi)
KW - Tremellaceae
KW - Tremellales
KW - Tremellomycetes
KW - Agaricomycotina
KW - Basidiomycota
KW - fungi
KW - eukaryotes
KW - Trichosporon
KW - Trichosporonaceae
KW - antigenic determinants
KW - antigenicity
KW - capsule
KW - complex carbohydrates
KW - fungus
KW - Hyphomycetes
KW - immunogens
KW - saccharides
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201578&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The International Dairy Federation's procedure for the validation of microbiological analytical methods for dairy foods.
AU - Hitchins, A. D.
JO - Food Control
JF - Food Control
Y1 - 1996///
VL - 7
IS - 1
SP - 13
EP - 18
SN - 0956-7135
AD - Hitchins, A. D.: US Food and Drug Administration Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19960403202. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The International Dairy Federation (IDF/FIL) empirically validates standard microbiological methods for the international dairy industry by using groups of qualified experts. Typically, a logical progression of inter-laboratory performance studies conducted by several laboratories leads to a validated method. Control of milk product matrices and analytes in inter-laboratory studies, however, is not rigid. Inter-laboratory reproducibility is not usually considered of vital importance because of the difficulty of establishing test-sample homogeneity with low numbers of microorganisms. However, the recent Listeria monocytogenes standard was validated by testing identical inoculated samples after preliminary inter-laboratory studies. Formerly, IDF/FIL preferred to validate only conventional methods that were widely used in dairy microbiology laboratories rather than novel rapid commercial kit methods. IDF/FIL Standards are internationally recognized.
KW - accuracy
KW - analytical methods
KW - bacterial count
KW - biodeterioration
KW - coliform count
KW - dairy industry
KW - determination
KW - food safety
KW - International Dairy Federation
KW - methodology
KW - microorganisms
KW - milk
KW - milk products
KW - milk testing
KW - standards
KW - testing
KW - World
KW - listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - dairy products
KW - International IDF
KW - methods
KW - micro-organisms
KW - worldwide
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960403202&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a multiplex PCR assay for the simultaneous detection and discrimination of HIV-1, HIV-2, HTLV-I and HTLV-II.
AU - Heredia, A.
AU - Soriano, V.
AU - Weiss, S. H.
AU - Bravo, R.
AU - Vallejo, A.
AU - Denny, T. N.
AU - Epstein, J. S.
AU - Hewlett, I. K.
JO - Clinical and Diagnostic Virology
JF - Clinical and Diagnostic Virology
Y1 - 1996///
VL - 7
IS - 2
SP - 85
EP - 92
SN - 0928-0197
AD - Heredia, A.: Laboratory of Molecular Virology, Division of Transfusion and Transmited Diseases, Center for Biologies Evaluation and Research, Food and Drug Administration, HFM-315, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19972010031. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - The aim of this study was to develop a multiplex PCR technique that can simultaneously detect and discriminate between HIV-1/2 and HTLV-I/II proviral sequences. Combinations of four primer pairs, one for each retrovirus, were assayed in order to determine the combination of oligonucleotides as well as the PCR conditions that yield the most specific and sensitive coamplification of proviral sequences. A combination of primer pairs from the gag region of HIV-1, env of HIV-2, pol of HTLV-I and tax of HTLV-II yielded specific and sensitive coamplification of proviral sequences. The uracil N-glycosylase system was incorporated into the coamplication format and shown to be efficient in the degradation of contaminating DNA. In the evaluation of a serologically well established panel of singly and dually infected individuals, the assay detected 20 of 22 HIV-1, 8 of 10 HIV-2, 8 of 8 HTLV-I and 8 of 8 HTLV-II infections.
KW - amplification
KW - contamination
KW - degradation
KW - detection
KW - DNA
KW - false positive results
KW - HIV-1 infections
KW - HIV-2 infections
KW - human diseases
KW - laboratory methods
KW - mixed infections
KW - nucleotides
KW - polymerase chain reaction
KW - Deltaretrovirus
KW - Human immunodeficiency virus 1
KW - Human immunodeficiency virus 2
KW - human T-cell lymphotropic virus type I
KW - human T-cell lymphotropic virus type II
KW - man
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Human T-cell lymphotropic virus
KW - Deltaretrovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - HTLV-BLV group
KW - human immunodeficiency virus type 1
KW - human immunodeficiency virus type 2
KW - laboratory techniques
KW - multiple infections
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010031&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition labelling of foods: comparisons between US regulations and Codex guidelines.
AU - Lewis, C. J.
AU - Randell, A.
AU - Scarbrough, F. E.
JO - Food Control
JF - Food Control
Y1 - 1996///
VL - 7
IS - 6
SP - 285
EP - 293
SN - 0956-7135
AD - Lewis, C. J.: Office of Food Labeling, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19971406866. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - This article compares recent nutrition labelling regulations issued by the USA and the international guidelines formulated by Codex Alimentarius. Factors under consideration were the continued benefits of a generalized Codex guideline as well as technical issues including analytical methods, nutrients to be declared, bases for declaration and reference values.
KW - comparisons
KW - consumers
KW - food policy
KW - foods
KW - guidelines
KW - labelling
KW - labelling controls
KW - nutrients
KW - nutrition labeling
KW - trade
KW - labeling
KW - labeling controls
KW - labels
KW - recommendations
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971406866&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US position on Listeria monocytogenes in foods.
AU - Shank, F. R.
AU - Elliot, E. L.
AU - Wachsmuth, I. K.
AU - Losikoff, M. E.
JO - Food Control
JF - Food Control
Y1 - 1996///
VL - 7
IS - 4/5
SP - 229
EP - 234
SN - 0956-7135
AD - Shank, F. R.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19970400921. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition; Dairy Science; Public Health
N2 - Public health and regulatory agencies in the USA have established a zero-tolerance for L. monocytogenes in cooked, ready-to-eat foods. The US response to listeriosis has included emphasis on 'good manufacturing practices' and Hazard Analysis Critical Control Point systems for processing, recommendations for hygiene and other measures for retail handling, and consumer education targeted at populations at highest risk of listeriosis.
KW - control
KW - food poisoning
KW - foods
KW - hygiene
KW - listeriosis
KW - microbial contamination
KW - milk products
KW - public health
KW - quality controls
KW - risk factors
KW - North America
KW - USA
KW - Listeria
KW - Listeria monocytogenes
KW - man
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - dairy products
KW - listerellosis
KW - quality assurance
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970400921&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay.
AU - Weiss, C. D.
AU - Barnett, S. W.
AU - Cacalano, N.
AU - Killeen, N.
AU - Littman, D. R.
AU - White, J. M.
JO - AIDS
JF - AIDS
Y1 - 1996///
VL - 10
IS - 3
SP - 241
EP - 246
SN - 0269-9370
AD - Weiss, C. D.: Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Room 532, HFM-413, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19962003745. Publication Type: Journal Article. Language: English. Number of References: 39 ref.
KW - cd4 antigens
KW - CD4+ lymphocytes
KW - cell membranes
KW - envelope protein gp41
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - laboratory methods
KW - pathogenesis
KW - phenotypes
KW - syncytia
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - CD4
KW - CD4+ cells
KW - fusion
KW - gp41
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - laboratory techniques
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003745&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolations of Potosi virus from mosquitoes collected in the United States, 1989-94.
AU - Mitchell, C. J.
AU - Smith, G. C.
AU - Karabatsos, N.
AU - Moore, C. G.
AU - Francy, D. B.
AU - Nasci, R. S.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1996///
VL - 12
IS - 1
SP - 1
EP - 7
SN - 8756-971X
AD - Mitchell, C. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 89522, USA.
N1 - Accession Number: 19960503553. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Potosi (POT) virus, a recently characterized Bunyamwera serogroup virus, was discovered when it was isolated from Aedes albopictus collected at a waste-tyre site in Potosi, Washington County, Missouri, during 1989. During the following year, POT virus was not isolated from 39,048 mosquitoes, including 17 519 A. albopictus, collected in Washington County. In 1991, Mosquito collections from South Carolina, Ohio and Michigan yielded 8 strains of POT virus: 6 from Coquillettidia perturbans and 1 each from Culex restuans and Psorophora columbiae. Additional collections of A. albopictus from several states during 1990-93 failed to yield further isolates of POT virus. In 1994, POT virus was isolated from A. albopictus and Anopheles punctipennis in North Carolina and from Aedes albopictus in Illinois. These represent the first virus isolations of any type from A. albopictus in those states. Thus far, POT virus has been isolated from 5 mosquito species in different genera in 6 states. The known geographic range of POT virus, based on virus isolations, has been extended from Missouri to the upper Midwest and the Atlantic seaboard. Potential vector relationships and possible transmission cycles of POT virus are discussed.
KW - arboviruses
KW - disease vectors
KW - epidemiology
KW - introduced species
KW - Illinois
KW - Michigan
KW - Missouri
KW - North Carolina
KW - Ohio
KW - South Carolina
KW - USA
KW - Aedes albopictus
KW - Anopheles punctipennis
KW - Bunyamwera virus
KW - Coquillettidia perturbans
KW - Culex restuans
KW - Culicidae
KW - Diptera
KW - Orthobunyavirus
KW - Psorophora columbiae
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Coquillettidia
KW - Culex
KW - Psorophora
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - Lake States of USA
KW - West North Central States of USA
KW - Appalachian States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - Bunyamwera serogroup viruses
KW - Bunyavirus
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Potosi virus
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503553&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Population size, parity structure, and wing length of Coquillettidia perturbans in an Ohio focus of eastern equine encephalitis.
AU - Nasci, R. S.
AU - Berry, R. L.
AU - Restifo, R. A.
AU - Moore, C. G.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1996///
VL - 12
IS - 1
SP - 64
EP - 68
SN - 8756-971X
AD - Nasci, R. S.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19960503786. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Adult female density, parity status and wing length were determined weekly for a population of C. perturbans in an area enzootic for eastern equine encephalitis virus in central Ohio, USA. Samples were collected in CO2-baited CDC miniature light traps from the 1st week in June through the 2nd week of September 1992. Population density indicated a single emergence peak during the 2nd week in July. However, parity rates showed 2 peaks, occurring in the 1st week of August (70.9% parous) and the 2nd week of September (55.3% parous), which suggested that there was a relatively small 2nd generation. Average wing length declined significantly over the season. The decline in size was negatively correlated with average air temperature occurring at least 6 weeks before the time of emergence. Despite the seasonal decline in wing length, the low coefficient of variation for the average wing length (5.5) indicated relatively little variation in size. Comparison of parous and nulliparous female wing lengths each week suggested that there was no association between size and survival in this species.
KW - age structure
KW - ecology
KW - environmental factors
KW - light traps
KW - parous rates
KW - population ecology
KW - size
KW - survival
KW - temperature
KW - wings
KW - Ohio
KW - USA
KW - Coquillettidia perturbans
KW - Culicidae
KW - Diptera
KW - Coquillettidia
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - mosquitoes
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Behaviour (LL300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503786&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood.
AU - Hagiwara, E.
AU - Sacks, T.
AU - Leitman-Klinman, S. F.
AU - Klinman, D. M.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1996///
VL - 12
IS - 2
SP - 127
EP - 133
SN - 0889-2229
AD - Hagiwara, E.: Laboratory of Retroviral Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19962003561. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9008-11-1.
KW - CD4 antigens
KW - cytokines
KW - disease course
KW - HIV-1 infections
KW - human diseases
KW - interferon
KW - interleukins
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CD4
KW - disease progression
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003561&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cupric and ferric ions inactivate HIV.
AU - Sagripanti, J. L.
AU - Lightfoote, M. M.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1996///
VL - 12
IS - 4
SP - 333
EP - 336
SN - 0889-2229
AD - Sagripanti, J. L.: Molecular Biology Branch (HFZ-113), Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19962004671. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 20074-52-6.
KW - antiviral agents
KW - ferric ions
KW - HIV-1 infections
KW - human diseases
KW - inactivation
KW - virucides
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - cupric ions
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962004671&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene.
AU - Husain, S. R.
AU - Leland, P.
AU - Aggarwal, B. B.
AU - Puri, R. K.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1996///
VL - 12
IS - 14
SP - 1349
EP - 1359
SN - 0889-2229
AD - Husain, S. R.: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972000006. Publication Type: Journal Article. Language: English. Number of References: 64 ref.
N2 - In Raji cells, 125I-labelled interleukin 4 (IL-4) cross-linked to 3 proteins of 140, 70 and 63 kDa, which were immunoprecipitated with an antibody to the human IL-4 receptors (IL-4R). Although this level of all 3 IL-4 binding proteins increased in tat-transfected cells, the binding characteristics of the IL-4R on control or mock transfected control and tat-transfected cells remained similar. The exogenous recombinant Tat protein or supernatant of tat transfected Raji cells also up-regulated the expression of the IL-4R on 2 renal cell carcinoma cell lines in a concentration-dependent manner. The actinomycin D chase experiments revealed that the half-lives of the IL-4R protein (t1/2 3.5 hours) and the mRNA transcripts (t1/2 2.5 hours) were similar in both control and tat-transfected cells. In contrast, nuclear run-on experiments revealed that the rate of the IL-4R mRNA transcription increased 3- to 5-fold in Raji-tat compared with Raji cells. These data indicated that the HIV-1 tat gene up-regulates IL-4R expression by increasing the transcription rate rather than post-transcriptional stabilization of either the mRNA or the protein. HIV-tat inducible exogenous tumour necrosis factor (TNF-α) did not up-regulate IL-4R and IL-4 inducible activation of signal transducers and activators of transcription (STAT-6) was not observed by Tat even though IL-4R were up-regulated. It is suggested that HIV-1 tat may interact directly with the IL-4R gene and up-regulate IL-4R transcription.
KW - cytokines
KW - hiv infections
KW - human diseases
KW - interleukins
KW - microbiology
KW - regulatory genes
KW - tat gene
KW - tat protein
KW - transcription
KW - viral regulatory proteins
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - DNA transcription
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000006&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Arboviruses associated with mosquitoes from nine Florida counties during 1993.
AU - Mitchell, C. J.
AU - Morris, C. D.
AU - Smith, G. C.
AU - Karabatsos, N.
AU - Vanlandingham, D.
AU - Cody, E.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1996///
VL - 12
IS - 2, Part 1
SP - 255
EP - 262
SN - 8756-971X
AD - Mitchell, C. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19960505074. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Mosquitoes were collected for virus isolation from 36 sites in Bradford, Lake, Leon, Manatee, Orange, Osceola, Pasco, Putnam and Sarasota counties, Florida, USA, from 6 April to 11 October 1993. A total of 158 129 adult specimens was collected in 726 trap nights using CDC light traps, usually baited with carbon dioxide. At least 35 species were represented, although 60% of the collections was made up of 3 species (Aedes infirmatus, 6.5%; Anopheles crucians, 14.4%; and Culex nigripalpus, 39.4%). Four of the 36 collecting sites were located at waste tyre sites, where 254 trap nights yielded 27 455 specimens (17.4% of 9-county total). 43 virus strains were isolated from 2812 mosquito pools consisting of 158 129 specimens. The viruses isolated include eastern equine encephalitis (EEE), 5 strains; Everglades (EVE), 2 strains; Keystone (KEY), 6 strains; Tensaw (TEN), 21 strains; trivittatus (TVT), 1 strain; Shark River (SR), 1 strain; and Flanders (FLA), 1 strain. In addition, 2 strains that are either KEY or Jamestown Canyon (JC) virus, and 4 ungrouped viruses remain to be identified. 21 (48.8%) of the 43 virus strains were isolated from mosquitoes collected at waste tyre sites as follows: EEE (1), KEY (5), KEY/JC (1), TEN (13) and 1 ungrouped virus. EEE virus was isolated from Culiseta melanura, Culex erraticus and Culex spp., EVE virus from Aedes spp., KEY virus from A. albopictus, A. atlanticus/A. infirmatus and Aedes spp., KEY or JC virus from A. atlanticus/A. tormentor and C. nigripalpus, TEN virus from A. atlanticus/A. tormentor, Aedes spp. and Anopheles crucians, TVT virus from Aedes spp., SR virus from C. opisthopus, and FLA virus from Culiseta melanura.
KW - arboviruses
KW - bait traps
KW - disease vectors
KW - epidemiology
KW - introduced species
KW - light traps
KW - surveys
KW - tyres
KW - Florida
KW - North America
KW - USA
KW - Aedes
KW - Aedes albopictus
KW - Aedes atlanticus
KW - Aedes infirmatus
KW - Aedes tormentor
KW - Anopheles crucians
KW - Culex
KW - Culex erraticus
KW - Culex nigripalpus
KW - Culex taeniopus
KW - Culicidae
KW - Culiseta melanura
KW - Diptera
KW - eastern equine encephalitis virus
KW - Everglades virus
KW - Flanders virus
KW - Jamestown Canyon virus
KW - trivittatus virus
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Anopheles
KW - Culex
KW - Culiseta
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - Culex opisthopus
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - Keystone virus
KW - mosquitoes
KW - naturalized species
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Ochlerotatus
KW - Ochlerotatus atlanticus
KW - Ochlerotatus infirmatus
KW - Ochlerotatus tormentor
KW - Shark River virus
KW - Tensaw virus
KW - tires
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960505074&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and reduction of sources of dietary lead in the United States.
AU - Bolger, P. M.
AU - Yess, N. J.
AU - Gunderson, E. L.
AU - Troxell, T. C.
AU - Carrington, C. D.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1996///
VL - 13
IS - 1
SP - 53
EP - 60
SN - 0265-203X
AD - Bolger, P. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19961403936. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Lead, an environmental contaminant, originates from a variety of sources. For over two decades, the US Food and Drug Administration (FDA) has made a number of efforts to reduce dietary lead exposure of the general population, and especially of vulnerable subpopulations such as infants and children and, indirectly, the fetus. Through cooperation with infant food manufacturers, reductions of about 80-90% in the lead content of infant foods were achieved, primarily through eliminating the use of cans for infant food products and following good manufacturing practices. Another major reduction in dietary lead was realized by discontinuing the use of lead solder in domestically produced food cans. FDA has also taken steps to minimize or further reduce sources of lead in the diet from lead glazes on ceramic-ware, leaded crystal-ware, dietary supplements, bottled water, and lead capsules on wine bottles. These actions have resulted in a considerable decrease in the exposure of the US population to dietary lead.
KW - bottled water
KW - canned products
KW - ceramics
KW - children
KW - fetus
KW - food contamination
KW - food safety
KW - food supplements
KW - glass
KW - heavy metals
KW - infant feeding
KW - infants
KW - intake
KW - lead
KW - wines
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - foetus
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403936&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk analysis of dietary lead exposure.
AU - Carrington, C. D.
AU - Bolger, P. M.
AU - Scheuplein, R. J.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1996///
VL - 13
IS - 1
SP - 61
EP - 76
SN - 0265-203X
AD - Carrington, C. D.: Contaminants Standards Monitoring and Programs Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19961403937. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7440-70-2, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Distribution of intake and lead levels in dietary and non-dietary sources and of lead absorption were used in a Monte-Carlo simulation to predict blood lead levels in populations of concern. Blood lead concentrations were estimated with and without particular dietary sources, and added risk was estimated for each source. These calculations permit comparisons of relative risk used to evaluate and limit dietary exposure to lead. Added risk of exposure to lead in wine, calcium supplements and ceramic-ware, and drinking water were calculated for adult men, pregnant women and children, respectively.
KW - blood
KW - calcium
KW - ceramics
KW - children
KW - drinking water
KW - exposure
KW - food contamination
KW - heavy metals
KW - lead
KW - men
KW - mineral supplements
KW - minerals
KW - pregnancy
KW - risk
KW - toxicity
KW - wines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - gestation
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961403937&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US Food and Drug Administration survey of cadmium, lead and other elements in clams and oysters.
AU - Capar, S. G.
AU - Yess, N. J.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1996///
VL - 13
IS - 5
SP - 553
EP - 560
SN - 0265-203X
AD - Capar, S. G.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19961406645. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Between 1985-86, the US Food and Drug Administration estimated concentrations of cadmium, lead and other elements in fresh clams and oysters collected from US coastal areas in use for shellfish production. Shellfish were analysed for Cd and Pb using a dry ash-anodic stripping voltammetric method. Other elements (aluminium, arsenic, beryllium, calcium, chromium, cobalt, copper, iron, magnesium, manganese, molybdenum, nickel, phosphorus, potassium, selenium, sodium, strontium, vanadium and zinc) were estimated using inductively coupled plasma-atomic emission spectrometry, direct current plasma-atomic emission spectrometry or hydride generation atomic absorption spectrometry. 75 hardshell clam, 59 softshell clam, 104 Eastern oyster and 40 Pacific oyster samples were examined. Average concentrations were Cd 0.09, 0.05, 0.51 and 1.1 mg/kg wet weight and Pb 0.24, 0.30, 0.11 and 0.06 mg/kg wet weight in hardshell clams, softshell clams, Eastern oysters and Pacific oysters, respectively. Concentrations of the other 19 elements were estimated in 10-104 samples of the 4 types of shellfish.
KW - cadmium
KW - clams
KW - elements
KW - food
KW - food contamination
KW - heavy metals
KW - lead
KW - minerals
KW - oysters
KW - shellfish
KW - trace elements
KW - USA
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - microelements
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961406645&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lead migration from lead crystal wine glasses.
AU - Hight, S. C.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1996///
VL - 13
IS - 7
SP - 747
EP - 765
SN - 0265-203X
AD - Hight, S. C.: Elemental Research Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19961410193. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition
N2 - Lead release from crystal wine glasses was estimated at 15 contact times from 1 min to 24 h (1440 min) in 4% acetic acid and wine at room temperature. Lead release, in both extractants, at 1 min was ~50 and 30% of cumulative lead release estimated at 30 and 1440 min, respectively. Pb release at 1440 min was 467 ng/ml in acetic acid and 358 ng/ml in wine. Pb release was also estimated under conditions that simulated consumer use: chilled or room temperature wine was steadily removed from vessels during 1-30 min of contact. Results were not significantly decreased compared with results of experiments in which wine temperature was 20.0±2.5 °C and contact area was constant. In repeated-leaching experiments, total µg of Pb released in 30 min decreased and was a function of 1/L², where L was leach number. Wine results fit a linear regression model of Pb release vs. square root of time which was previously proposed to describe corrosion of lead silicate glass by acetic acid. Slopes and intercepts of the square-root-of-time model were used to explain results of repeated-leaching experiments.
KW - alcoholic beverages
KW - glass
KW - glassware
KW - heavy metals
KW - leaching
KW - lead
KW - wines
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410193&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunogenicity, efficacy and safety of an oral rabies vaccine (SAG-2) in dogs.
AU - Fekadu, M.
AU - Nesby, S. L.
AU - Shaddock, J. H.
AU - Schumacher, C. L.
AU - Linhart, S. B.
AU - Sanderlin, D. W.
JO - Vaccine
JF - Vaccine
Y1 - 1996///
VL - 14
IS - 6
SP - 465
EP - 468
SN - 0264-410X
AD - Fekadu, M.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19962211093. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - The immunogenicity and efficacy of Street Alabama Gif (SAG-2) attenuated rabies virus vaccine was tested in 4 groups of 10 laboratory Beagles given 1.0 ml of SAG-2 orally on the tongue or 1.5 ml in baits. On day 180 after vaccination, all dogs were challenged with a street rabies virus. The antibody response in groups given the vaccine directly on the tongue was higher than in those vaccinated with baits, but the difference between groups was not statistically significant. All vaccinated dogs survived, whereas 80% of controls died of rabies. It is concluded that SAG-2 is a safe and effective vaccine for oral immunization of dogs.
KW - application methods
KW - baits
KW - experimental infections
KW - immunization
KW - live vaccines
KW - oral administration
KW - rabies
KW - viral diseases
KW - dogs
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - attenuated vaccines
KW - immune sensitization
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Pets and Companion Animals (LL070)
KW - Laboratory Animal Science (LL040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962211093&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of fumonisin mycotoxins in animals.
AU - Bucci, T. J.
AU - Howard, P. C.
A2 - Ghoneim, M. A.
A2 - Sobh, M. A.
A2 - Yahya, R. S.
JO - Journal of Toxicology, Toxin Reviews
JF - Journal of Toxicology, Toxin Reviews
Y1 - 1996///
VL - 15
IS - 3
SP - 293
EP - 302
SN - 0731-3837
AD - Bucci, T. J.: Division of Biochemical Toxicology and Pathology Associates International, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971201132. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 40 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology
N2 - Fumonisin toxicity in animals is discussed, including fumonisin effects in laboratory animals, reproductive effects and mechanism of toxicity.
KW - fumonisins
KW - kidney diseases
KW - laboratory animals
KW - mycotoxicoses
KW - mycotoxins
KW - poisoning
KW - reproductive performance
KW - toxicity
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - kidney disorders
KW - mycotoxin poisoning
KW - nephropathy
KW - Ochratoxin as an environmental risk factor causing kidney disease
KW - renal diseases
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201132&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breast-feeding and HIV transmission: epidemiologic studies and their limitations.
AU - Timbo, B.
AU - Altekruse, S.
AU - Fowler, M. G.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1996///
VL - 16
IS - 5
SP - 759
EP - 768
SN - 0271-5317
AD - Timbo, B.: Epidemiology Branch, HFS-728, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19961404999. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Postnatal human immunodeficiency virus (HIV) transmission from mother to child has been attributed mostly to breast-feeding. However, the mechanism and timing of HIV transmission via breast-feeding and the risk factors for this mode of transmission are not well defined. A series of case reports and cohort studies have provided useful but incomplete information on the transmission of HIV via breast-feeding. Various studies have yielded risk estimates of 15-40%. The stage of the HIV infection in the mother and the immunological constituents of human milk have been suggested as important determinants of HIV transmission via breast-feeding.
KW - acquired immune deficiency syndrome
KW - breast feeding
KW - epidemiology
KW - human immunodeficiency viruses
KW - human milk
KW - infants
KW - research
KW - transmission
KW - man
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - breast milk
KW - human immunodeficiency virus
KW - studies
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404999&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary fibers on gastrointestinal mucin in rats.
AU - Satchithanandam Subramaniam
AU - Klurfeld, D. M.
AU - Calvert, R. J.
AU - Cassidy, M. M.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1996///
VL - 16
IS - 7
SP - 1163
EP - 1177
SN - 0271-5317
AD - Satchithanandam Subramaniam: Office of Special Nutritionals, Division of Science and Applied Technology, Food and Drug Administration, MOD-1, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19961407183. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9004-34-6. Subject Subsets: Horticultural Science; Human Nutrition
N2 - Effects of feeding 3 different dietary fibres on gastrointestinal mucin production were examined. 42 male Wistar rats (150-175 g) were fed ad libitum on diets containing 10 or 20% cellulose, psyllium or rice bran or a control diet containing no fibre. After 4 weeks, stomachs, small intestines and colons were removed and surface luminal mucin and tissue mucin were collected. Specimens were homogenized, the homogenates were centrifuged and the supernatants were assayed for mucin by an enzyme-linked immunosorbent assay technique. Results showed that concentrations of luminal and total (luminal plus tissue) gastric mucin were significantly increased in rats fed 20% psyllium compared with rats fed the control diet. There were no significant differences in concentration of small intestinal mucin among groups. Colonic luminal and total mucin concentrations, however, were significantly increased in rats fed 10% psyllium compared with rats fed on the control diet. Increase in colonic mucin concentrations was later confirmed by periodic acid Schiff staining. It was suggested that increased gastric and colonic mucin concentrations caused by psyllium treatment may protect these organs as well as alter nutrient absorption.
KW - cellulose
KW - colon
KW - digestive tract
KW - elisa
KW - fibre
KW - mucins
KW - mucus
KW - rice bran
KW - secretion
KW - small intestine
KW - sources
KW - stomach
KW - plantago
KW - plantago ovata
KW - rats
KW - Plantaginaceae
KW - Plantaginales
KW - Scrophulariales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Plantago
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - enzyme linked immunosorbent assay
KW - fiber
KW - gastrointestinal tract
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407183&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interactions of varying levels of dietary fat, carbohydrate, and fiber on food consumption and utilization, weight gain and fecal fat contents in female Sprague-Dawley rats.
AU - Jackson, C. D.
AU - Weis, C.
AU - Poirier, L. A.
AU - Bechtel, D. H.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1996///
VL - 16
IS - 10
SP - 1735
EP - 1747
SN - 0271-5317
AD - Jackson, C. D.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19961410672. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - The purpose of this study was to better define a nutritional regime for the DMBA-induced rat mammary tumour model for studying the interdependent effects of fats, carbohydrates and fibre on mammary tumour development. Female Sprague-Dawley rats were administered (ad libitum) a modified AIN-76A diet containing different ratios of dietary fat, carbohydrate and fibre for 6 weeks. Food consumption was decreased in the higher fat groups, but the decrease did not compensate completely for the higher energy density of the diets. Energy consumption and body weight gain were greater in the mid and high than in the low fat groups. Dietary fibre had only a marginally significant effect on food consumption but did decrease energy consumption and body weight gain in the high fat groups. There was no significant interaction between fat and fibre with respect to food or energy consumption, but there was a marginally significant interaction between these two dietary components on body weight gain. Food utilization, with respect to weight gain, was increased by fat and decreased by fibre, with a significant antagonistic interaction between the two. Energy utilization (g weight gain/100 kcal) was increased by increased fat but the effect of fibre was not significant. Dry faecal weight was increased by dietary fibre and decreased by dietary fat. The amount of faecal fat excreted was increased by dietary fibre but the effects of dietary fat on faecal fat excretion were inconsistent. The results indicate a complex interaction of dietary fat and fibre. Rats administered the low fat/high fibre diet consumed the least number of energy and thus would be the control group in a pair fed, isoenergetic study.
KW - carbohydrates
KW - faeces
KW - fats
KW - fibre
KW - food intake
KW - intake
KW - mammary gland neoplasms
KW - weight gain
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - feces
KW - fiber
KW - mammary tumour
KW - saccharides
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410672&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human ehrlichiosis in the United States.
AU - Dawson, J. E.
JO - Current Clinical Topics in Infectious Diseases
JF - Current Clinical Topics in Infectious Diseases
Y1 - 1996///
VL - 16
SP - 164
EP - 171
AD - Dawson, J. E.: Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Atlanta, GA, USA.
N1 - Accession Number: 19970503967. Publication Type: Journal Article. Language: English. Number of References: 28 ref.
KW - diagnosis
KW - ehrlichioses
KW - epidemiology
KW - human diseases
KW - reviews
KW - therapy
KW - USA
KW - Ehrlichia
KW - Ehrlichia chaffeensis
KW - man
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ehrlichia
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - Ehrlichia infections
KW - ehrlichiosis
KW - therapeutics
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970503967&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells.
AU - Tolleson, W. H.
AU - Melchior, W. B., Jr.
AU - Morris, S. M.
AU - McGarrity, L. J.
AU - Domon, O. E.
AU - Muskhelishvili, L.
AU - James, S. J.
AU - Howard, P. C.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1996///
VL - 17
IS - 2
SP - 239
EP - 249
SN - 0143-3334
AD - Tolleson, W. H.: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19961201930. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The cellular effects of fumonisin B1 were examined in vitro using cellular model systems relevant to potential human target tissues. Fumonisin B1 inhibited incorporation of [³H]thymidine by cultured neonatal human keratinocytes and HepG2 human hepatocarcinoma cells at 10-7 and 10-4M, respectively. Fumonisin B1 also inhibited clonal expansion of normal human keratinocytes and HET-1A human oesophageal epithelial cells at 10-5M and growth in mass culture of normal human fibroblasts at 10-7M. The clonogenicity of normal human keratinocytes decreased to 45.5% of controls after exposure to 10-4M fumonisin B1 for 2 d. However, no differences in the cell cycle distribution of cultured keratinocytes was noted after exposure to 10-5M fumonisin B1 for 40 h. The viability of normal human keratinocytes and HET-1A cells decreased as a result of fumonisin B1 treatment, as determined by a fluorescein diacetate/propidium iodide flow cytometric cell viability assay. Fumonisin B1-treated keratinocytes released nucleosomal DNA fragments into the medium 2-3 d after exposure to 10-4M fumonisin B1 and increased DNA strand breaks were detected in attached keratinocytes exposed to 0-10-4M fumonisin B1 using a terminal deoxynucleotidyl transferase-based immunochemical assay system. Furthermore, fumonisin B1-treated keratinocytes and HET-1A cells developed morphological features consistent with apoptosis, as determined by phase contrast microscopy, fluorescent microscopy of acridine orange stained cells and electron microscopy. It is concluded that these results are consistent with the occurrence of fumonisin B1-mediated apoptosis in vitro.
KW - apoptosis
KW - cell cycle
KW - cytopathogenicity
KW - epithelium
KW - fumonisins
KW - liver
KW - mycotoxins
KW - oesophagus
KW - skin
KW - toxicity
KW - viability
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dermis
KW - esophagus
KW - fungal toxins
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201930&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology: applications of nucleic acid amplification and sequence analysis.
AU - McDade, J. E.
AU - Anderson, B. E.
JO - Epidemiologic Reviews
JF - Epidemiologic Reviews
Y1 - 1996///
VL - 18
IS - 1
SP - 90
EP - 97
SN - 0193-936X
AD - McDade, J. E.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19972009942. Publication Type: Journal Article. Language: English. Number of References: 46 ref.
N2 - This review covers the following topics: principles of the approach to molecular epidemiology using nucleic acid sequence analysis; investigating disease outbreaks of unknown aetiology: the hantavirus investigation; detection and identification of bacteria resistant to cultivation (Whipple's disease, bacillary angiomatosis/cat scratch disease, ehrlichiosis); establishing unusual modes of disease transmission: HIV and dentists; verifying unusually long incubation periods in rabies infections; paleomicrobiology.
KW - aetiology
KW - bacillary angiomatosis
KW - cat scratch disease
KW - dentistry
KW - detection
KW - disease transmission
KW - dna amplification
KW - epidemiology
KW - human diseases
KW - human immunodeficiency viruses
KW - nucleic acids
KW - reviews
KW - techniques
KW - whipple's disease
KW - bartonella henselae
KW - bartonella quintana
KW - Deltaretrovirus
KW - ehrlichia
KW - hantavirus
KW - human t-cell lymphotropic virus
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Bartonella
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Anaplasmataceae
KW - Rickettsiales
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Deltaretrovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - causal agents
KW - etiology
KW - HTLV-BLV group
KW - human immunodeficiency virus
KW - paleomicrobiology
KW - tropheryma whippelii
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009942&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of adjuvants on murine immune responses against the C-terminal 19 kDa fragment of Plasmodium vivax merozoite surface protein-1 (MSP-1).
AU - Yang ChunFu
AU - Collins, W. E.
AU - Xiao LiHua
AU - Patterson, P. S.
AU - Reed, R. C.
AU - Hunter, R. L.
AU - Kaslow, D. C.
AU - Lal, A. A.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 1996///
VL - 18
IS - 11
SP - 547
EP - 558
SN - 0141-9838
AD - Yang ChunFu: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Service, Atlanta, GA 30341, USA.
N1 - Accession Number: 19970800979. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 308067-58-5. Subject Subsets: Protozoology
N2 - The immunogenicity of a yeast-expressed 19 kDa fragment of Plasmodium vivax MSP-1 (merozoite surface protein-1) in the presence of different adjuvant formulations was evaluated. ICR mice were immunized with the 19 kDa antigen, using as adjuvants one of Freund's, alum, or block copolymer P1005 (the last-named in water-in-oil (W/O) or oil-in-water (O/W) emulsions, with or without detoxified lipopolysaccharide (RaLPS)). Five weeks following immunization with the antigen, mice were boosted with asexual blood-stage antigens. Three weeks after the last immunization with the 19 kDa antigen, mice from the Freund's group and most groups that received P1005 as adjuvant had higher total IgG titres than those that received alum as adjuvant or antigen alone. Antibody responses after the antigen immunization were predominantly of the IgG1 isotype, but mice in the Freund's and P1005 (W/O or O/W emulsion with or without RaLPS) groups also had high titres of IgG2a and IgG2b. Antibody titres against merozoites increased in all groups after the parasite antigen boost. IgG2a levels in the group that received antigen in P1005 plus RaLPS in the W/O emulsion were higher than those receiving Freund's, alum or the other copolymer adjuvants. The high IgG2a titres in this group were associated with reduced IL-10 production.
KW - adjuvants
KW - IgG
KW - immune response
KW - laboratory animals
KW - malaria
KW - merozoites
KW - parasites
KW - recombinant proteins
KW - surface proteins
KW - mice
KW - Plasmodium vivax
KW - protozoa
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - immunity reactions
KW - immunological reactions
KW - membrane proteins
KW - merozoite surface protein-1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800979&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dietary restriction on benzo[a]pyrene (BaP) metabolic activation and pulmonary BaP-DNA adduct formation in mouse.
AU - Chen Wen
AU - Zhou YongGui
AU - Nichols, J.
AU - Chung KingThom
AU - Hart, R. W.
AU - Chou, M. W.
JO - Drug and Chemical Toxicology
JF - Drug and Chemical Toxicology
Y1 - 1996///
VL - 19
IS - 1/2
SP - 21
EP - 39
SN - 0148-0545
AD - Chen Wen: National Center for Toxicological Research, Jefferson, AR, USA.
N1 - Accession Number: 19971403848. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 50-32-8. Subject Subsets: Human Nutrition
N2 - Acute dietary restriction (DR; 60% of the food consumption of ad libitum (AL)-fed mice for 7 weeks) reduced the body weights of male B6C3F1 mice, and increased mouse pulmonary cytochrome P4501A1-dependent benzo[a]pyrene (BaP) metabolizing enzyme activity. The effects of DR on the formation of the specific BaP-DNA adduct, 10-(N²-deoxyguanosinyl)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-BaP (BaP-N²-dG) in mouse lung was detected by using a 32P-postlabelling technique. In AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 h after treatment with [³H]BaP and the in vivo formation of BaP-N²-dG was 22% greater in DR mouse lung than in AL mouse lung by 22%. DR increased in vitro BaP-N²-dG formation by 39% when calf-thymus DNA was incubated with BaP using liver microsomes obtained from DR- or AL-mice as the enzyme source. The formation of the specific BaP-N²-dG adducts, was only 20% of the total [³H]BaP-DNA adducts as measured by liquid scintillation counting. The increase of BaP-DNA adduct formation in mouse lung was correlated with the enhancement of the mouse pulmonary BaP metabolizing enzyme activity. In conclusion, the results indicated that the effect of DR on the metabolic activation of BaP in mouse lung was dependent upon the mouse lung cytochrome P4501A1-dependent BaP metabolizing enzymes activities which were significantly increased by DR.
KW - benzopyrene
KW - carcinogens
KW - DNA modification
KW - energy intake
KW - food restriction
KW - lungs
KW - metabolism
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403848&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of an improved method for the analysis of pesticides and their metabolites in the urine of farmer applicators and their families.
AU - Shealy, D. B.
AU - Bonin, M. A.
AU - Wooten, J. V.
AU - Ashley, D. L.
AU - Needham, L. L.
AU - Bond, A. E.
JO - Environment International
JF - Environment International
Y1 - 1996///
VL - 22
IS - 6
SP - 661
EP - 675
SN - 0160-4120
AD - Shealy, D. B.: Division of Environmental Health Laboratory Sciences, National Center of Environmental Health, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19980500943. Publication Type: Journal Article. Language: English. Number of References: 36 ref.
N2 - A method for measuring simultaneously the urinary residues of as many as 20 pesticides has been significantly improved. The method uses a sample preparation which includes enzyme digestion, extraction, and chemical derivatization of the analytes. The derivatized analytes are measured by using gas chromatography coupled with isotope-dilution tandem mass spectrometry. The limits of detection of the modified method are in the high pg/litre to low µg/litre range, and the average coefficient of variation of the method was below 20% for most analytes, with ~100% accuracy in quantification. This method was used to measure the internal doses of pesticides among selected farmer applicators and their families in the USA. Definite exposure and elimination patterns (i.e. an increase in urinary analyte levels following application and then a gradual decrease to background levels) were observed among the farmer applicators and many of the family members whose crops were treated with carbaryl, dicamba, and 2,4-D esters and amines. Although the spouses of farm workers sometimes exhibited the same elimination pattern, the levels of the targeted pesticides or metabolites found in their urine were not outside the ranges found in the general US population (reference range). The farmer applicators who applied the pesticides and some of their children appeared to have higher pesticide or metabolite levels in their urine than those found in the general US population, but their levels were generally comparable to or lower than reported levels in other occupationally exposed individuals. These results, however, were obtained from a nonrandom sampling of farm residents specifically targeted to particular exposures who may have altered their practices because they were being observed; therefore, further study is required to determine if these results are representative of pesticide levels among residents on all farms where these pesticides are applied using the same application techniques. Using this method to measure exposure in a small nonrandom farm population allowed differentiation between overt and background exposure. In addition, the important role of reference-range information in distinguishing between various levels of environmental exposure was reaffirmed.
KW - analysis
KW - analytical methods
KW - children
KW - chromatography
KW - detection
KW - exposure
KW - families
KW - farm workers
KW - farmers
KW - metabolites
KW - pesticide residues
KW - pesticides
KW - populations
KW - public health
KW - spraymen
KW - urine
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500943&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of α-tocopherol and β-carotene on hepatic lipid peroxidation and blood lipids in rats with dietary iron overload.
AU - Whittaker, P.
AU - Wamer, W. G.
AU - Chanderbhan, R. F.
AU - Dunkel, V. C.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1996///
VL - 25
IS - 2
SP - 119
EP - 128
SN - 0163-5581
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20001413415. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 59-02-9, 7235-40-7, 57-88-5, 7439-89-6. Subject Subsets: Human Nutrition
N2 - The ability of dietary antioxidants to reduce lipid peroxidation induced by iron overload was examined in weanling male Sprague-Dawley rats. Animals were fed ad libitum a modified AIN-76A diet (control) or control diet with 0.5% α-tocopherol acid succinate, 0.5% crystalline trans-β-carotene, or 0.5% α-tocopherol acid succinate+0.5% trans-β-carotene for four weeks. In the following four-week period, the animals received the above diets with Fe, 10 000 µg/g; a control group continued to receive Fe, 35 µg/g, and a high-iron group received Fe, 10 000 µg/g with no antioxidants. After four weeks of dietary supplementation with α-tocopherol, β-carotene, or α-tocopherol+β-carotene, liver concentrations of α-tocopherol and β-carotene increased significantly (P<0.001). Liver lipid peroxidation, measured by the lipid-conjugated diene assay, increased significantly from 0.012 µmol/mg of lipid in the controls to 0.021 µmol/mg of lipid in animals receiving the high-iron diet. However, lipid peroxidation was significantly reduced in all animals fed the antioxidants, with the group fed α-tocopherol+β-carotene having a lower level than the high-iron group. Total serum cholesterol was elevated in animals fed a high-iron diet and in animals fed the high-iron diet with α-tocopherol. In contrast, total serum cholesterol levels in the two groups of animals receiving the diets containing high iron with β-carotene alone or high iron with β-carotene+α-tocopherol were significantly reduced to the level of the control group. High-density lipoprotein cholesterol also decreased to baseline in the animals receiving β-carotene alone. It is concluded that modulation of lipid peroxidation by α-tocopherol or β-carotene may be an important mechanism for reducing oxidative stress.
KW - alpha-tocopherol
KW - antioxidants
KW - beta-carotene
KW - blood
KW - blood lipids
KW - cholesterol
KW - iron
KW - lipid peroxidation
KW - lipids
KW - lipoproteins
KW - liver
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lipins
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413415&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycology and indoor air quality.
AU - Hung LingLing
JO - Laboratory Medicine
JF - Laboratory Medicine
Y1 - 1996///
VL - 27
IS - 7
SP - 454
EP - 460
SN - 0007-5027
AD - Hung LingLing: US Public Health Service, Division of Federal Occupational Health, Philadelphia, PA 19104, USA.
N1 - Accession Number: 19971201441. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Indoor fungi and their growth, fungal proliferation in indoor environments, health effects, investigating fungal contamination of indoor environments, and control of fungal problems in indoor environments are discussed.
KW - air microbiology
KW - air spora
KW - allergies
KW - control
KW - environment
KW - homes
KW - human diseases
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Plant Composition (FF040)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201441&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Shift work, shift change, and risk of death from heart disease at work.
AU - Steenland, K.
AU - Fine, L.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1996///
VL - 29
IS - 3
SP - 278
EP - 281
SN - 0271-3586
AD - Steenland, K.: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA.
N1 - Accession Number: 19962008862. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - Some epidemiological studies suggest workers who rotate shift are at increased risk of cardiovascular disease, but no studies have investigated the effect of shift for workers who do not rotate. To determine whether current shift or recent change in shift was a risk factor for ischaemic heart disease, a nested case-control study of heart disease death at work was conducted within a cohort of 21 000 men working at 4 heavy equipment plants in the USA. 1563 men who died of ischaemic heart disease at work or within 1 week of working were identified and compared to 781 controls who were working at the same age but did not die. Plant personnel records were used to determine duration of time on current shift. At the time of case death, 72% of study subjects were working on first shift, 22% on second, and 6% on third. The average time on shift without shift change was 9 years. There was little evidence of any difference in heart disease risk by current shift. There was some indication that recent change from afternoon or night shift to day shift had a protective effect initially, which decreased over time. On the other hand, no corresponding negative effect was found for a change from first to second/third shift, regardless of when the change took place.
KW - cardiovascular diseases
KW - heart diseases
KW - human diseases
KW - men
KW - mortality
KW - occupational health
KW - occupations
KW - shift work
KW - shift workers
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - coronary diseases
KW - death rate
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008862&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of SKF 108922, an HIV-1 protease inhibitor, on retrovirus replication in mice.
AU - Black, P. L.
AU - Ussery, M. A.
AU - Barney, S.
AU - Wittrock, R.
AU - DeMarsh, P.
AU - Dreyer, G. B.
AU - Petteway, S. R. Jr.
AU - DalMonte, P.
AU - Baldoni, J.
AU - Lambert, D. M.
JO - Antiviral Research
JF - Antiviral Research
Y1 - 1996///
VL - 29
IS - 2/3
SP - 175
EP - 186
SN - 0166-3542
AD - Black, P. L.: Division of Antiviral Drug Products, Center for Drug Evaluation and Research, HFD-535, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19962008293. Publication Type: Journal Article. Language: English. Number of References: 43 ref.
KW - animal models
KW - antiviral agents
KW - HIV-1 infections
KW - human diseases
KW - proteinase inhibitors
KW - Human immunodeficiency virus 1
KW - mice
KW - Murine leukemia virus
KW - simian immunodeficiency virus
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gammaretrovirus
KW - human immunodeficiency virus type 1
KW - murine leukaemia virus
KW - protease inhibitors
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008293&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Taking the fat out of food.
AU - Kurtzweil, P.
JO - FDA Consumer
JF - FDA Consumer
Y1 - 1996///
VL - 30
IS - 6
SP - 7
EP - 13
SN - 0362-1332
AD - Kurtzweil, P.: Food and Drug Administration, USA.
N1 - Accession Number: 19961408571. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
KW - food legislation
KW - lipid substitutes
KW - low fat products
KW - Food Processing (General) (QQ100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961408571&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fighting fleas and ticks.
AU - Farley, D.
JO - FDA Consumer
JF - FDA Consumer
Y1 - 1996///
VL - 30
IS - 6
SP - 23
EP - 29
SN - 0362-1332
AD - Farley, D.: c/o FDA Consumer, Food and Drug Administration (HFI-40), USDA, Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19970504729. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science
KW - acaricides
KW - chemical control
KW - control
KW - insecticides
KW - pets
KW - safety
KW - USA
KW - cats
KW - Ctenocephalides
KW - dogs
KW - Ixodes
KW - Ixodidae
KW - Siphonaptera
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pulicidae
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Canis
KW - Canidae
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - pet animals
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504729&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of methylisoborneol in channel catfish pond water by solid phase extraction followed by gas chromatography-mass spectrometry.
AU - Conte, E. D.
AU - Conway, S. C.
AU - Miller, D. W.
AU - Perschbacher, P. W.
JO - Water Research (Oxford)
JF - Water Research (Oxford)
Y1 - 1996///
VL - 30
IS - 9
SP - 2125
EP - 2127
SN - 0043-1354
AD - Conte, E. D.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971404201. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - A rapid, inexpensive, nonspecialized method is described for the analysis of methylisoborneol (MIB), a compound responsible for unwanted taste and odour characteristics in edible catfish (Ictalurus punctatus), which is produced through the metabolism of cyanobacteria in aqueous systems such as reservoirs and ponds. The method utilizes C18 solid-phase extraction followed by capillary gas chromatography with detection by mass spectrometry. Standard MIB and the internal standard, butylisoborneol, were prepared from the reaction of D-camphor with methylmagnesium chloride and n-butyllithium, respectively. Extraction efficiencies for MIB channel catfish pond water averaged 89% at 101 parts per trillion (PPT) and 845 at 202 parts per billion. The detection limit of the method was calculated to be 11.5 ppt.
KW - analytical methods
KW - flavour compounds
KW - gas chromatography
KW - mass spectrometry
KW - metabolites
KW - cyanobacteria
KW - fishes
KW - Ictalurus punctatus
KW - Bacteria
KW - prokaryotes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - analytical techniques
KW - bacterium
KW - flavor compounds
KW - Techniques and Methodology (ZZ900)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Biology and Ecology (MM300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404201&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of alimentary exposure to Listeria monocytogenes.
AU - Hitchins, A. D.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 1996///
VL - 30
IS - 1/2
SP - 71
EP - 85
SN - 0168-1605
AD - Hitchins, A. D.: Division of Microbiological Studies (HFS-516), Food and Drug Administration, 200 C Street, S.W. Washington, DC 20204, USA.
N1 - Accession Number: 19970401272. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - US field survey data on the occurrence of L. monocytogenes in different foods and dietary intakes of different foods were obtained from literature published between 1987 and 1992. Data were restricted to ready-to-eat (RTE) foods (including meats and cheeses) which were regarded as the major source of exposure, because proper cooking was assumed to be listericidal. The mean amount of a food per L. monocytogenes occurrence was calculated in from about 100 samples of each food. Dietary intake data were used to calculate the mean number of occurrences of L. monocytogenes consumption per person annually. The mean number of occurrences consumed annually per person was estimated to be 10 to 100 for RTE food values of 2 to 20% of the total dietary intake, respectively. The frequency of foodborne listeriosis (approximately 10-5) was consistent with the estimated exposure rate only if the susceptible population was unexpectedly small or extremely high doses were necessary for infection. Because little evidence is available to support a high rate of unreported non-severe infections, this study focused on severe cases of listeriosis. Published frequencies of L. monocytogenes concentrations in food were used to convert occurrences to colony forming units (cfu). Low L. monocytogenes concentrations (approximately 1 cfu/g) were too frequent to be responsible for listeriosis in susceptible subjects and would have caused listeriosis only with extremely low probability in a one-cell threshold infection model. It was concluded that the probability of exposure to a higher dose (≥10³ cfu) was large enough to account for the observed rate of listeriosis.
KW - contamination
KW - determination
KW - estimation
KW - food intake
KW - foods
KW - intake
KW - listeriosis
KW - occurrence
KW - USA
KW - Listeria
KW - listeria monocytogenes
KW - man
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - listerellosis
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970401272&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical toxicity of antiretroviral nucleoside analogs.
AU - Styrt, B. A.
AU - Piazza-Hepp, T. D.
AU - Chikami, G. K.
JO - Antiviral Research
JF - Antiviral Research
Y1 - 1996///
VL - 31
IS - 3
SP - 121
EP - 135
SN - 0166-3542
AD - Styrt, B. A.: Division of Epidemiology and Surveillance, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19962006531. Publication Type: Journal Article. Language: English. Number of References: 122 ref. Registry Number: 69655-05-6, 7841-89-2, 30516-87-1, 134678-17-4, 3056-17-5.
KW - analogues
KW - didanosine
KW - dideoxycytidine
KW - drug therapy
KW - drug toxicity
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - lamivudine
KW - nucleoside analogues
KW - nucleosides
KW - reviews
KW - stavudine
KW - zidovudine
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analogs
KW - AZT
KW - chemotherapy
KW - dideoxyinosine
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - nucleoside analogs
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006531&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sensitive PCR diagnosis of infections by Enterocytozoon bieneusi (Microsporidia) using primers based on the region coding for small-subunit rRNA.
AU - Silva, A. J. da
AU - Schwartz, D. A.
AU - Visvesvara, G. S.
AU - Moura, H. de
AU - Slemenda, S. B.
AU - Pieniazek, N. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1996///
VL - 34
IS - 4
SP - 986
EP - 987
SN - 0095-1137
AD - Silva, A. J. da: Division of Parasitic Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19970800957. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Public Health
N2 - Enterocytozoon bieneusi is the most common microsporan infecting patients with AIDS. A polymerase chain reaction (PCR) primer pair (EBIEF1/EBIER1) was developed, based on the small-subunit rRNA sequence of this parasite. Compared with other PCR-based methods, this primer pair showed a higher efficiency of detection in diagnostic applications than another previously described primer pair, V1/EB450.
KW - acquired immune deficiency syndrome
KW - diagnosis
KW - diagnostic techniques
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - infections
KW - microsporidiosis
KW - opportunistic infections
KW - parasites
KW - polymerase chain reaction
KW - protozoal infections
KW - ribosomal RNA
KW - Enterocytozoon bieneusi
KW - man
KW - protozoa
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Enterocytozoon
KW - Enterocytozoonidae
KW - Microspora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - AIDS
KW - human immunodeficiency virus
KW - PCR
KW - protozoal diseases
KW - rRNA
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970800957&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of transforming activity of fumonisin B1 in BALB/3T3 A31-1-1 mouse embryo cells.
AU - Sheu, C. W.
AU - Rodriguez, I.
AU - Eppley, R. M.
AU - Lee, J. K.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1996///
VL - 34
IS - 8
SP - 751
EP - 753
SN - 0278-6915
AD - Sheu, C. W.: Genetic Toxicology Branch, Division of Molecular Biological Research and Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington DC 20204, USA.
N1 - Accession Number: 19961202398. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The capacity of fumonisin B1 (FB1) to induce morphological transformation of cultured mammalian cells was assessed using BALB/3T3 A31-1-1 mouse embryo cells. FB1 with 90% purity was prepared from Fusarium proliferatum grown on whole maize. Cell growth was not inhibited by 48 h of exposure at concn up to 1000 µg/ml. Moderate inhibition was induced by 6 d of exposure. In transformation assays with a 48-h exposure, increases in transformed foci were observed at some concn, although the responses were not reproducible. Prolonged exposure for up to 4 wk at 10, 100 and 500 µg/ml failed to induce increases in transformed foci. Analysis of combined results showed that only the increase induced by a 48-h exposure at 500 µg/ml was significant. A trend test indicated the lack of a dose response for concn of 10-1000 µg/ml. It is concluded that FB1 lacks in vitro transforming activity.
KW - cytotoxicity
KW - fumonisins
KW - genetic transformation
KW - mycotoxins
KW - production
KW - toxicity
KW - toxins
KW - Fusarium proliferatum
KW - Fusarium
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Plant Composition (FF040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202398&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid detection of Mycobacterium avium in stool samples from AIDS patients by immunomagnetic PCR.
AU - Li ZhongMing
AU - Bai GilHan
AU - Reyn, C. F. von
AU - Marino, P.
AU - Brennan, M. J.
AU - Gine, N.
AU - Morris, S. L.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1996///
VL - 34
IS - 8
SP - 1903
EP - 1907
SN - 0095-1137
AD - Li ZhongMing: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19962006905. Publication Type: Journal Article. Language: English. Number of References: 28 ref.
KW - acquired immune deficiency syndrome
KW - bacterial diseases
KW - detection
KW - diagnosis
KW - faeces
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - opportunistic infections
KW - polymerase chain reaction
KW - man
KW - Mycobacterium avium
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - AIDS
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - feces
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunomagnetic polymerase chain reaction
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962006905&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The polymerase chain reaction: applications for the detection of foodborne pathogens.
AU - Hill, W. E.
JO - CRC Critical Reviews in Food Science and Nutrition
JF - CRC Critical Reviews in Food Science and Nutrition
Y1 - 1996///
VL - 36
IS - 1/2
SP - 123
EP - 173
SN - 1040-8398
AD - Hill, W. E.: Seafood Products Research Center, Seattle District Office, Office of Regulatory Affairs, Food and Drug Administration, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19961300899. Publication Type: Journal Article. Language: English. Number of References: 294 ref. Subject Subsets: Human Nutrition
N2 - The major features and requirements for polymerase chain reaction (PCR) are described along with a number of important variations. A considerable number of PCR-based assays have been developed, but they are applied most often to clinical and environmental samples and more rarely for the detection of foodborne microorganisms. Much of the difficulty in implementing PCR for food analysis lies in the problems encountered during the preparation of template DNAs from food matrices; a variety of approaches and considerations are examined. PCR methods developed for the detection and identification of particular bacteria, viruses, and parasites found in foods are described and discussed, and the major features of these reactions are summarized.
KW - applications
KW - biodeterioration
KW - detection
KW - foodborne diseases
KW - parasites
KW - pathogens
KW - polymerase chain reaction
KW - techniques
KW - viruses
KW - PCR
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961300899&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis.
AU - Narcisi, E. M.
AU - Secor, W. E.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 1996///
VL - 40
IS - 5
SP - 1121
EP - 1125
SN - 0066-4804
AD - Narcisi, E. M.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341-3717, USA.
N1 - Accession Number: 19960803755. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 67-45-8, 443-48-1, 19387-91-8. Subject Subsets: Protozoology
N2 - Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat Trichomonas vaginalis infection. Because some patients have severe reactions to this drug and others are infected with metronidazole-resistant T. vaginalis, alternative therapies are being investigated. Tinidazole, another 5-nitroimidazole which has been used to treat T. vaginalis infections, and furazolidone, a nitrofuran presently used to treat giardiasis and some anaerobic enteric bacterial infections, were investigated for effectiveness against 9 metronidazole-susceptible and 12 metronidazole-resistant T. vaginalis isolates. The in vitro aerobic and anaerobic minimum lethal concentrations (MLC) and the time for drug efficacy were determined. Tinidazole killed the metronidazole-susceptible isolates at a low MLC but was effective against only 4 of the 12 metronidazole-resistant isolates. In contrast, furazolidone was effective at a low MLC for all isolates. When tinidazole was effective, it required >6 h to kill trichomonads, whereas furazolidone killed both metronidazole-susceptible and -resistant trichomonads within 2 to 3 h of exposure. The data indicate that furazolidone may be a good candidate for treating metronidazole-resistant trichomoniasis.
KW - antiprotozoal agents
KW - drug resistance
KW - drug therapy
KW - furazolidone
KW - human diseases
KW - in vitro
KW - metronidazole
KW - nitrofurans
KW - nitroimidazoles
KW - parasites
KW - tinidazole
KW - trichomoniasis
KW - man
KW - protozoa
KW - Trichomonas vaginalis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Trichomonas
KW - Trichomonadidae
KW - Trichomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - chemotherapy
KW - trichomonosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803755&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of time, temperature, and pH on the stability of fumonisin B1 in an aqueous model system.
AU - Jackson, L. S.
AU - Hlywka, J. J.
AU - Senthil, K. R.
AU - Bullerman, L. B.
AU - Musser, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1996///
VL - 44
IS - 3
SP - 906
EP - 912
SN - 0021-8561
AD - Jackson, L. S.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 19961201769. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - The effects of processing time and temp. on fumonisin B1 (FB1, 5 p.p.m.) stability in aqueous solutions at pH 4, 7, and 10 were determined. Analysis of the thermally processed solutions by LC/MS indicated the predominant presence of hydrolysis products of FB1. The rate and extent of FB1 decomposition increased with processing temp. After processing at ≤125°C for 60 min, <27% of FB1 was lost; after 60 min at 150°C, 18-90% was lost, depending on buffer pH. Overall, FB1 was least stable at pH 4 followed by pH 10 and 7, respectively. At ≥175°C, >90% of FB1 was lost after processing for 60 min, regardless, of pH. It is concluded that FB1 levels may be substantially reduced in foods that reach ≥150°C during processing.
KW - contamination
KW - decomposition
KW - foods
KW - fumonisins
KW - heat treatment
KW - inactivation
KW - mycotoxins
KW - ph
KW - stability
KW - temperature
KW - fungal toxins
KW - heat processing
KW - hydrogen ion concentration
KW - potential of hydrogen
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961201769&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of trichlorfon and dichlorvos residues in shrimp using gas chromatography with nitrogen-phosphorus detection.
AU - Ngoh, M. A.
AU - Cullison, R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1996///
VL - 44
IS - 9
SP - 2686
EP - 2689
SN - 0021-8561
AD - Ngoh, M. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19972206773. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 62-73-7, 52-68-6. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science
N2 - A method capable of quantifying trichlorfon and dichlorvos in shrimp (Penaeus vannamei)at concentrations of 20-80 ng/g was developed. Ground shrimp is homogenized in ethyl acetate and centrifuged. The supernatant is dried completely on a rotatory evaporator. The extract is dissolved in petroleum ether, concentrated on a solid phase extraction column, and analysed by gas chromatography using a cool on-column inlet and a nitrogen-phosphorus detector. The analytes are separated from matrix components using a thermal gradient on a (cyanopropyl)phenyl-methylpolysiloxane column. The method was validated with control shrimp fortified at 20, 40, and 80 ng/g trichlorfon and dichlorvos. The average recoveries and intralaboratory coefficients of variations were 50-83% and 15-21% respectively.
KW - detection
KW - determination
KW - dichlorvos
KW - drug residues
KW - gas chromatography
KW - residues
KW - trichlorfon
KW - USA
KW - Penaeus
KW - Penaeidae
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - shrimps
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chlorofos
KW - chlorophos
KW - DDVP
KW - metrifonate
KW - trichlorphon
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972206773&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HPLC determination of sulfadiazine residues in coho salmon (Oncorhynchus kisutch) with confirmation by liquid chromatography with atmospheric pressure chemical ionization mass spectrometry.
AU - Gehring, T. A.
AU - Rushing, L. G.
AU - Churchwell, M. I.
AU - Doerge, D. R.
AU - McErlane, K. M.
AU - Thompson, H. C., Jr.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1996///
VL - 44
IS - 10
SP - 3164
EP - 3169
SN - 0021-8561
AD - Gehring, T. A.: Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19972206771. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 68-35-9. Subject Subsets: Veterinary Science; Veterinary Science
N2 - High-performance liquid chromatography and postcolumn derivatization with fluorescamine were used to determine sulfadiazine (SDZ) residues in muscle and skin from salmon dosed with Tribrissen. Determinations in the fish ranged from 0.2 to 21 600 ng of SDZ/g; in each fish tested, the concentration of SDZ in the skin was at least twice that in the muscle. Liquid chromatography with atmospheric pressure chemical ionization mass spectrometry (LC-APCI/MS) was used to confirm SDZ residues. In-source collision induced dissociation was optimized to produce a mass spectrum containing the protonated molecule and four fragment ions. Sulfadiazine was confirmed in muscle fortified with 10 ng of SDZ/g and in muscle from fish dosed with SDZ by the accurate agreement of ion intensity ratios generated from muscle compared with those generated from SDZ standard injections.
KW - assays
KW - atmospheric pressure
KW - determination
KW - drug residues
KW - hplc
KW - ionization
KW - liquid chromatography
KW - mass spectrometry
KW - residues
KW - sulfadiazine
KW - oncorhynchus kisutch
KW - salmon
KW - Salmonidae
KW - Oncorhynchus
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - barometric pressure
KW - high performance liquid chromatography
KW - sulphadiazine
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972206771&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of cyclic fatty acid monomer 2-alkenyl-4,4-dimethyloxazoline derivatives by gas chromatography-matrix isolation-Fourier transform infrared spectroscopy.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - McDonald, R. E.
AU - Flickinger, B. D.
AU - Perkins, E. G.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1996///
VL - 44
IS - 10
SP - 3193
EP - 3196
SN - 0021-8561
AD - Mossoba, M. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-717, Washington, D.C. 20204, USA.
N1 - Accession Number: 19971401126. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 8001-26-1. Subject Subsets: Human Nutrition
N2 - Cyclic fatty acid monomers (CFAMs) were isolated from heated flaxseed oil and analysed as 2-alkenyl-4,4-dimethyloxazoline (DMOX) derivatives by capillary gas chromatography-matrix isolation-Fourier transform infrared spectroscopy. The fragmentation patterns produced were then used to estimate ring and double-bond positions along the hydrocarbon chain. These values were compared with those from a previous study where CFAMs were isolated from heated flaxseed oil and analysed as methyl ester (ME) derivatives by GC-MI-FTIR. The FTIR spectra observed for the DMOX derivatives of this CFAM mixture were consistent with the earlier FTIR results obtained for the corresponding ME derivatives. Mass spectral data observed for deuterated analogues are also reported.
KW - analysis
KW - chemical structure
KW - derivatives
KW - fatty acids
KW - gas chromatography
KW - heat treatment
KW - infrared spectroscopy
KW - linseed oil
KW - heat processing
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971401126&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Suffocations in grain bins - Minnesota, 1992-1995.
AU - Wahl, G. L.
AU - Folken, S. E.
AU - Boyle, D. J.
AU - Parker, D. L.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
VL - 45
IS - 39
SP - 837
EP - 841
SN - 0149-2195
AD - Wahl, G. L.: Minnesota Dept of Health, Div of Safety Research, National Institute for Occupational Safety and Health, CDC, USA.
N1 - Accession Number: 19972400266. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Agricultural Engineering; Wheat, Barley & Triticale Abstracts
N2 - This report describes investigations into 3 of the 9 deaths during 1992-1995 in Minnesota due to suffocation after becoming engulfed in flowing grain within a grain storage structure.The findings in this report indicate that suffocation in grain bins is a continuing source of preventable death among workers in the agriculture industry. Recommendations on education and procedures are given.
KW - accident prevention
KW - accidents
KW - cereals
KW - death
KW - grain
KW - grain stores
KW - safety
KW - safety at work
KW - safety devices
KW - stores
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - storage structures
KW - storehouses
KW - United States of America
KW - Storage Equipment (NN500) (Discontinued March 2000)
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972400266&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Defining the public health impact of drug-resistant Streptococcus pneumoniae: report of a working group.
AU - Jernigan, D. B.
AU - Cetron, M. S.
AU - Breiman, R. F.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
VL - 45
IS - RR-1
SP - iii + 20
EP - iii + 20
SN - 0149-2195
AD - Jernigan, D. B.: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19962005127. Publication Type: Miscellaneous. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - To develop a strategy for minimizing the impact of drug-resistant Streptococcus pneumoniae (DRSP), in June 1994, CDC convened a working group of public health practitioners, clinical laboratorians, health-care providers, and representatives of key professional societies. This report describes the three goals developed by the working group that address surveillance, epidemiological investigation, and prevention and control of DRSP, and the objectives for each goal.
KW - drug resistance
KW - human diseases
KW - infections
KW - public health
KW - North America
KW - USA
KW - man
KW - Streptococcus pneumoniae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005127&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Prevention of varicella. Recommendations of the Advisory Committee on Immunization Practices (ACIP).
AU - Holmes, S. J.
AU - Reef, S.
AU - Hadler, S. C.
AU - Williams, W. W.
AU - Wharton, M.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
VL - 45
IS - RR-11
SP - iv + 36
EP - iv + 36
SN - 0149-2195
AD - Holmes, S. J.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19962008820. Publication Type: Miscellaneous. Language: English. Number of References: 118 ref. Subject Subsets: Public Health
N2 - These recommendations represent the first statement by the US Advisory Committee on Immunization Practices (ACIP) on the use of live, attenuated varicella virus vaccine-VARIVAX®-manufactured by Merck and Company, Inc. and licensed in March 1995 for use in healthy persons ≥12 months of age. In addition to presenting information regarding the vaccine this statement updates previous recommendations concerning the use of varicella zoster immune globulin (VZIG) as prophylaxis against varicella.
KW - disease prevention
KW - guidelines
KW - human diseases
KW - immunization
KW - live vaccines
KW - vaccination
KW - vaccines
KW - varicella
KW - viral diseases
KW - North America
KW - USA
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - attenuated vaccines
KW - chicken pox
KW - immune sensitization
KW - recommendations
KW - United States of America
KW - varicella-zoster virus
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008820&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Community-level prevention of human immunodeficiency virus infection among high-risk populations: the AIDS community demonstration projects.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
VL - 45
IS - RR-6
SP - 1
EP - 24
SN - 0149-2195
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982002592. Publication Type: Journal Article; Annual report; Journal article. Corporate Author: USA, Centers for Disease Control and Prevention Language: English.
N2 - The AIDS Community Demonstration Projects (ACDPs) were community-level human immunodeficiency virus-prevention programmes targeting high-risk populations in 5 cities in the USA. For the intervention design, researchers developed a common study protocol based on behaviour-change theories and models. This report describes the common study protocol used in the ACDPs, the preliminary findings, and the conclusions regarding the design, implementation, and evaluation of a community-level intervention; specific case studies from each project site are also described.
KW - acquired immune deficiency syndrome
KW - behaviour
KW - disease prevention
KW - human immunodeficiency viruses
KW - intervention
KW - populations
KW - prevention
KW - risk groups
KW - USA
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - behavior
KW - high risk groups
KW - human immunodeficiency virus
KW - programmes
KW - protocols
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Research (AA500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002592&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure to crystalline silica or treatment with chlorphentermine increases vitamin E levels in rat alveolar lavage materials.
AU - Miles, P. R.
AU - Bowman, L.
AU - Reasor, M. J.
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
Y1 - 1996///
VL - 49
IS - 5
SP - 511
EP - 523
SN - 0098-4108
AD - Miles, P. R.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19971402385. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 7631-86-9, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Vitamin E levels were measured in alveolar lavage materials from male Sprague-Dawley rats exposed to HCl-washed and unwashed crystalline silica or treated with chlorphentermine (CP) 25 mg/kg body weight, to increase surfactant phospholipids (PL). Exposure to HCl-washed silica resulted in a more than 17-fold increase in lavage PL and protein levels and a 12.2-fold increase in the amount of vitamin E. Exposure to unwashed silica lead to an approximately 7-fold increase in PL and proteins and a 5.8-fold increase in lavage vitamin E. Following treatment with CP, there was a 15-19-fold increase in lavage PL and proteins and a 13.6-fold increase in vitamin E. When the results were expressed as vitamin E µg/mg of lavage PL or protein, there was not much difference between controls and each treatment group. Because surfactant synthesis occurs in the endoplasmic reticulum, vitamin E was measured in lung microsomes. Silica exposure and CP treatment also lead to 1.8- to 2.5-fold increases, respectively, in the lung microsomal levels of vitamin E. These results demonstrate that alveolar lavage vitamin E levels are elevated along with lavage PL and proteins and lung microsomal vitamin E levels are increased following exposure of rats to silica or treatment of the rats with CP.
KW - endoplasmic reticulum
KW - lungs
KW - microsomes
KW - phospholipids
KW - proteins
KW - silica
KW - surfactants
KW - vitamin E
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - surface active agents
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402385&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Amphotericin B induced abnormalities in human platelets.
AU - Pastakia, K. B.
AU - Brownson, N. E.
AU - Terle, D. A.
AU - Poindexter, B. J.
JO - Clinical Molecular Pathology
JF - Clinical Molecular Pathology
Y1 - 1996///
VL - 49
IS - 5
SP - M301
EP - M307
SN - 1355-2910
AD - Pastakia, K. B.: Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 19961202416. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 1397-89-3. Subject Subsets: Medical & Veterinary Mycology
N2 - Washed platelets were isolated from platelet concentrates and exposed to amphotericin B (4 µg/ml) for 1 h. Platelet function was assessed by aggregation response to thrombin (0-0.6 U/ml), serotonin release, response to hypotonic stress and mean platelet volume. The expression of surface membrane glycoprotein (GP) Ib-IX complex, GPIIb-IIIa complex and CD62P (P-selectin) was examined by flow cytometry using fluorescence labelled monoclonal antibodies. Heterotypic cell adhesion was measured in amphotericin B treated platelets coincubated with isolated, autologous polymorphonuclear leukocytes (PMN) by flow cytometric analysis. Amphotericin B induced platelet dysfunction. The rate of aggregation by thrombin, serotonin uptake and thrombin induced release of serotonin, and the response of platelets to hypotonic stress were inhibited. There was up to a 2-fold increase in the mean platelet volume. The expression of platelet surface GPIb-IX and GPIIb-IIIa was not affected. P-selectin, normally expressed only on the surface of activated platelets, was also expressed on unactivated platelets. Amphotericin B increased platelet adherence to PMN and the number of platelets bound/PMN. It is concluded that in vitro amphotericin B induces P-selectin expression on the surface of unactivated platelets and increases platelet adhesion to PMN, which is exacerbated by storage. It is suggested that platelet dysfunction resulting from exposure to amphotericin B may contribute to poor platelet recovery in vivo when amphotericin B is administered concomitantly with platelet transfusion.
KW - adhesion
KW - amphotericin B
KW - antifungal agents
KW - drug toxicity
KW - flow cytometry
KW - glycoproteins
KW - neutrophils
KW - platelets
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood platelets
KW - fungistats
KW - thrombocytes
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961202416&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality of workers exposed to toluene diisocyanate in the polyurethane foam industry.
AU - Schnorr, T. M.
AU - Steenland, K.
AU - Egeland, G. M.
AU - Boeniger, M.
AU - Egilman, D.
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
Y1 - 1996///
VL - 53
IS - 10
SP - 703
EP - 707
SN - 1351-0711
AD - Schnorr, T. M.: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, Cincinnati, Ohio, 45226, USA.
N1 - Accession Number: 19962008563. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 108-88-3. Subject Subsets: Public Health
N2 - To evaluate cancer mortality among workers in the USA exposed to toluene diisocyanate (TDI) in the manufacture of polyurethane foam a cohort mortality study was conducted which included 4611 men and women employed in 4 polyurethane foam plants for at least 3 months between the late 1950s and 1987. The mortality experience of the cohort was then compared with that of the general US population. Current and past industrial hygiene data indicated that air concentrations in 1984-5 were below the current US standard of 0.04 mg/m³ but exceeded the standard before 1980. Mortality from rectal cancer (standardized mortality ratio (SMR) 2.78, 95% confidence interval (95% CI) 0.57-8.13) and non-Hodgkin's lymphoma (SMR 1.54, 95% CI 0.42-3.95) were increased, but not significantly. There was 1 male breast cancer. However, breast cancer was not increased in women (SMR 0.74). No other cancer category had an increased number of deaths compared with the general population. Only non-Hodgkin's lymphoma and Hodgkin's disease showed a possible relation with time since first employment and no cancer death category showed a strong relation with duration of employment. Mortality from non-malignant respiratory disease was not increased (SMR 0.86). It is concluded that this young cohort has few deaths and short follow up therefore the findings are not conclusive. Further years of follow up would enable better evaluation of mortality.
KW - breast cancer
KW - epidemiology
KW - human diseases
KW - incidence
KW - mortality
KW - neoplasms
KW - non-Hodgkin's lymphoma
KW - occupational health
KW - occupations
KW - rectal cancer
KW - rectum
KW - toluene
KW - toxicology
KW - workers
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - cancers
KW - death rate
KW - toluene diisocyanate
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008563&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Codex Alimentarius.
AU - Pothisiri, P.
AU - Kongchuntuk, H.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1996///
VL - 54
IS - 11, Part2
SP - S149
EP - S151
SN - 0029-6643
AD - Pothisiri, P.: Food and Drug administration, Ministry of Public Health, Nonthaburi 11000, Thailand.
N1 - Accession Number: 19971404986. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition
N2 - The paper briefly reviews the background and purpose of the Codex Alimentarius, the structure of the Codex Alimentarius commission, which is responsible for implementing the joint FAO/WHO Food Standards Program and the purpose of the Codex Committee on Nutrition and Foods for Specified Dietary Uses (CCFSDU, now the Codex Committee on Nutrition). It also briefly reviews the actions taken by the CCFSDU to improve global nutritional and food standards.
KW - Food and Agriculture Organization
KW - food legislation
KW - functional foods
KW - international organizations
KW - reviews
KW - WHO
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - FAO
KW - First international conference on East-West perspectives on functional foods
KW - World Health Organization
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404986&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory aspects of functional foods in Nigeria.
AU - Osuide, G. E.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1996///
VL - 54
IS - 11, Part2
SP - S167
EP - S167
SN - 0029-6643
AD - Osuide, G. E.: National Agency for Food and Drug Administration and Control (NAFDAC), Nigeria.
N1 - Accession Number: 19971404990. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 0 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - This paper briefly reviews how food legislation in Nigeria deals with functional foods.
KW - food legislation
KW - functional foods
KW - reviews
KW - Nigeria
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - First international conference on East-West perspectives on functional foods
KW - Laws and Regulations (DD500)
KW - Human Nutrition (General) (VV100)
KW - Food Composition and Quality (QQ500)
KW - Marketing and Distribution (EE700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404990&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The prospect for functional foods in Thailand.
AU - Pothisiri, P.
AU - Kongchuntuk, H.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 1996///
VL - 54
IS - 11, Part2
SP - S172
EP - S173
SN - 0029-6643
AD - Pothisiri, P.: Food and Drug Administration, Ministry of Public Health, Nonthaburi 11000, Thailand.
N1 - Accession Number: 19971404993. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - This paper briefly reviews the issues that must be considered before an effective regulatory measure can be established for a functional foods in Thailand. These issues are: product safety; safe use by consumers; product quality and standards; and claims and substantiation.
KW - consumer protection
KW - food legislation
KW - food quality
KW - food safety
KW - functional foods
KW - Thailand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - consumer advocacy
KW - First international conference on East-West perspectives on functional foods
KW - Laws and Regulations (DD500)
KW - Human Nutrition (General) (VV100)
KW - Food Composition and Quality (QQ500)
KW - Marketing and Distribution (EE700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404993&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Case study: control of methylene chloride exposures during furniture stripping.
AU - Estill, C. F.
AU - Spencer, A. B.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1996///
VL - 57
IS - 1
SP - 43
EP - 49
SN - 0002-8894
AD - Estill, C. F.: National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, 4676 Columbia Parkway, Mailstop R5, Cincinnati, Ohio 45226, USA.
N1 - Accession Number: 19962003743. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 75-09-2.
KW - exposure
KW - furniture
KW - methylene chloride
KW - occupational health
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dichloromethane
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003743&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Polymerase chain reaction evidence of Ehrlichia chaffeensis, an etiologic agent of human ehrlichiosis, in dogs from southeast Virginia.
AU - Dawson, J. E.
AU - Biggie, K. L.
AU - Warner, C. K.
AU - Cookson, K.
AU - Jenkins, S.
AU - Levine, J. F.
AU - Olson, J. G.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 1996///
VL - 57
IS - 8
SP - 1175
EP - 1179
SN - 0002-9645
AD - Dawson, J. E.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Resources, Atlanta, GA 30333, USA.
N1 - Accession Number: 19962214289. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - Dogs from 5 animal shelters and 1 kennel in 3 cities and 3 counties in southeastern Virginia were tested during June 1991. Blood was drawn from 74 dogs; 73 were tested for antibodies reactive to E. chaffeensis and E. canis by indirect fluorescent antibody assay, and 38 were tested for the presence of E. chaffeensis, E. canis and E. ewingii by polymerase chain reaction (PCR). Nested PCR used Ehrlichia-wide outside primers to detect initial products, followed by use of species-specific primers for identification. 28 (38.4%) dogs had a positive test result (minimum titre, ≥1:64) for antibodies reactive to E. chaffeensis, and 28 (38.4%) had a positive reaction to E. canis. PCR analysis indicated that 8 (42.1%) dogs were positive for E. chaffeensis and 6 dogs (31.6%) were positive for E. ewingii. All dogs had negative PCR results for E. canis. It is concluded that dogs are potential reservoirs of E. chaffeensis.
KW - bacterial diseases
KW - ehrlichioses
KW - epidemiology
KW - polymerase chain reaction
KW - reservoir hosts
KW - rickettsial diseases
KW - USA
KW - Virginia
KW - dogs
KW - Ehrlichia
KW - ehrlichia canis
KW - ehrlichia chaffeensis
KW - Ehrlichia ewingii
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ehrlichia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - animal reservoirs
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Ehrlichia infections
KW - ehrlichiosis
KW - PCR
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962214289&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimentally induced Bartonella henselae infections followed by challenge exposure and antimicrobial therapy in cats.
AU - Regnery, R. L.
AU - Rooney, J. A.
AU - Johnson, A. M.
AU - Nesby, S. L.
AU - Manzewitsch, P.
AU - Beaver, K.
AU - Olson, J. G.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 1996///
VL - 57
IS - 12
SP - 1714
EP - 1719
SN - 0002-9645
AD - Regnery, R. L.: Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19972212977. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 308067-58-5. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - [The following abstract replaces the earlier one because of incorrect data in the original paper. A correction of the information was published in AJVR 58 (8) pp 803, August 1997.] Six SPF cats were inoculated with either 2 × 107 colony-forming units (cfu) of B. henselae, 2 × 107 cfu of Bartonella quintana, or sham infected with diluent (2 cats per group). Cats inoculated with B. henselae developed bacteraemia within 1 week; bacteraemia persisted for longer than 2 months before subsiding spontaneously. IgG antibody titre developed shortly after onset of bacteraemia; antibody co-existed with bacteraemia for several weeks and remained detectable after bacteraemia subsided. Cats inoculated with B. quintana remained abacteraemic. On challenge exposure to B. henselae, cats previously infected with B. henselae remained abacteraemic; cats previously inoculated with B. quintana supported B. henselae infection. In a second experiment, 25 SPF cats were inoculated with 107 cfu of B. henselae and were allowed to develop bacteraemia. The cats were treated with erythromycin (11 to 22 mg/kg, every 8 h), tetracycline (13.75 mg/kg, every 6 h), enrofloxacin (2.5 mg/kg, every 12 h), amoxicillin (11 to 22 mg/kg, every 8 h) or were left untreated. Antibiotic treatments continued for 2 weeks between days 14 and 27 after infection. Temporal and quantitative aspects of bacteraemia in enrofloxacin- and amoxicillin-treated cats remained indistinguishable from those of control infected cats. Tetracycline and erythromycin depressed B. henselae bacteremia; however, duration of bacteraemia remained similar to that in untreated cats. Obvious signs of illness were not observed.<new para>ADDITIONAL ABSTRACT:<new para>Six SPF cats were inoculated with either 2 × 107 colony-forming units (cfu) of B. henselae, 2 × 107 cfu of Bartonella quintana, or sham infected with diluent (2 cats per group). Cats inoculated with B. henselae developed bacteraemia within 1 week; bacteraemia persisted for longer than 2 months before subsiding spontaneously. IgG antibody titre developed shortly after onset of bacteraemia; antibody co-existed with bacteraemia for several weeks and remained detectable after bacteraemia subsided. Cats inoculated with B. quintana remained abacteraemic. On challenge exposure to B. henselae, cats previously infected with B. henselae remained abacteraemic; cats previously inoculated with B. quintana supported B. henselae infection. In a second experiment, 25 SPF cats were inoculated with 107 cfu of B. henselae and were allowed to develop bacteraemia. The cats were treated with erythromycin (2.3 to 4.5 mg/kg, every 8 h), tetracycline (11.4 mg/kg, every 4 h), enrofloxacin (0.6 mg/kg, every 12 h), amoxicillin (2.3 to 4.5 mg/kg, every 8 h) or were left untreated. Antibiotic treatments continued for 2 weeks between days 14 and 27 after infection. Temporal and quantitative aspects of bacteraemia in enrofloxacin- and amoxicillin-treated cats remained indistinguishable from those of control infected cats. Tetracycline and erythromycin depressed B. henselae bacteremia; however, duration of bacteraemia remained similar to that in untreated cats. Obvious signs of illness were not observed.
KW - antibiotics
KW - bacteraemia
KW - bacterial diseases
KW - drug therapy
KW - experimental infection
KW - experimental infections
KW - IgG
KW - Bartonella
KW - bartonella henselae
KW - bartonella quintana
KW - cats
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bartonella
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacteremia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - experimental transmission
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972212977&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Virulence of Listeria monocytogenes, Listeria seeligeri, and Listeria innocua assayed with in vitro murine macrophagocytosis.
AU - Dallas, H. L.
AU - Thomas, D. P.
AU - Hitchins, A. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 1
SP - 24
EP - 27
SN - 0362-028X
AD - Dallas, H. L.: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street, S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19961301434. Publication Type: Journal Article. Language: English. Number of References: 24 ref.
N2 - The survival of virulent and avirulent Listeria species internalized in cells of a murine macrophage-like cell line, RAW264.7, was monitored. Mouse macrophage cells (~5 ×105/ml) suspended in fresh RPMI medium 1640 containing fetal bovine serum were mixed with 5 × 107 to 5 × 108Listeria cells/ml and incubated 1 h at 37 °C with CO2-enriched air. Gentamicin (10 µg/ml) was added to kill bacteria not internalized by the cells. At 2, 4, and 6 h postinfection. 10 µl amounts of the suspensions were lysed in microtitre plate wells during serial decimal dilution in water. Triplicate dilutions (10 µl each) were plated on trypticase soy agar, and colonies were counted after 48 h incubation at 35 °C. About 0.1 to 1% of the added hemolytic pathogen L. monocytogenes Scott A and the avirulent nonhemolytic L. innocua internalized at 2 h. The number of internal L. monocytogenes cells had increased significantly by 6 h, but L. innocua cells showed no significant change. A str. of the hemolytic species L. seeligeri behaved like the nonhemolytic L. innocua. This distinction between the intracellular behaviour of pathogenic and nonpathogenic species, if a general phenomenon, may be useful as an in vitro virulence assessment parameter.
KW - biodeterioration
KW - determination
KW - in vitro
KW - microscopy
KW - pathogens
KW - techniques
KW - tissue culture
KW - virulence
KW - bacteria
KW - Listeria
KW - Listeria innocua
KW - Listeria monocytogenes
KW - Listeria seeligeri
KW - prokaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Listeria
KW - bacterium
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence of Clostridium botulinum in vegetables packaged under vacuum or modified atmosphere.
AU - Lilly, T., Jr.
AU - Solomon, H. M.
AU - Rhodehamel, E. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 1
SP - 59
EP - 61
SN - 0362-028X
AD - Lilly, T., Jr.: Division of Microbiological Studies (HSF-516), U.S. Food and Drug Administration, 200 C Street, S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19961301440. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Horticultural Science; Postharvest Research
N2 - The incidence of Clostridium botulinum spores in commercially available, precut modified atmosphere-packaged (MAP) vegetables was determined. One-pound (454 g) packages of MAP vegetables were aseptically opened, added to freshly steamed and cooled sterile trypticase-peptone-glucose-yeast extract broth and incubated at 35 °C for 7 d. Positive and negative controls were included with each sampling. After incubation the broth cultures were tested for toxicity by the standard mouse bioassay. Of the 1118 MAP vegetable packages examined, one package each of shredded cabbage, chopped green pepper, and Italian salad mix contained C. botulinum type A spores. One additional salad mix (main ingredient, escarole) contained both C. botulinum type A and type B spores. Results indicated a low overall incidence rate (0.36%) of C. botulinum spores in commercially available precut MAP vegetables.
KW - biodeterioration
KW - contamination
KW - minimal processing
KW - packaging
KW - vacuum packaging
KW - vegetables
KW - bacteria
KW - Clostridium botulinum
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - bacterium
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Storage and Preservation (QQ110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961301440&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neurobehavioral dysfunctions associated with dietary iron overload.
AU - Sobotka, T. J.
AU - Whittaker, P.
AU - Sobotka, J. M.
AU - Brodie, R. E.
AU - Quander, D. Y.
AU - Robl, M.
AU - Bryant, M.
AU - Barton, C. N.
JO - Physiology & Behavior
JF - Physiology & Behavior
Y1 - 1996///
VL - 59
IS - 2
SP - 213
EP - 219
SN - 0031-9384
AD - Sobotka, T. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Adminstration, Washington, DC, USA.
N1 - Accession Number: 19961402532. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Excessive dietary iron is known to be toxic, but the extent of neurobiological involvement is not clear. Male weanling Sprague-Dawley rats were fed on diets containing Fe at 35 (control), 350, 3500 or 20 000 mg/kg for 12 weeks. An Fe-deficient group (4 mg/kg) was included for comparison. Rats were tested for behavioural and body weight changes at various times after initiation of diets, and liver and brain nonheme Fe were estimated at term. Excess dietary Fe, primarily at 20 000 mg/kg, significantly decreased activity, habituation, reflex startle and conditioned avoidance response performance, and enhanced prepulse modulation of startle. Body weights were also decreased. Fe-deficient rats showed similar behavioural effects but more moderate body weight changes. Liver nonheme Fe varied directly with dietary levels. Whole-brain nonheme Fe was significantly reduced in Fe-deficient rats but increased only at the 20 000 mg/kg level. Homeostatic mechanisms appear to regulate whole-brain Fe more effectively under conditions of dietary Fe overload than under conditions of Fe deficiency. The behavioural changes associated with dietary Fe overload may represent secondary consequences of systemic toxicity.
KW - behaviour
KW - body weight
KW - iron
KW - nervous system
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961402532&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumer knowledge of foodborne microbial hazards and food-handling practices.
AU - Altekruse, S. F.
AU - Street, D. A.
AU - Fein, S. B.
AU - Levy, A. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 3
SP - 287
EP - 294
SN - 0362-028X
AD - Altekruse, S. F.: Division of Market Studies, Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 19961301557. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - A national telephone survey was conducted of 1620 randomly selected USA residents who spoke English, were at least 18 years old, and resided in households with kitchen facilities. Respondents were interviewed about their recognition of foodborne pathogens, foods at risk for transmitting infection, knowledge of safe food handling, and food-handling practices. One-third of the respondents who prepared meals reported unsafe food hygiene practices: e.g., they did not wash hands or take precautions to prevent cross-contamination from raw meat. Unsafe practices were reported more often by men, adults 18 to 29 years of age, and occasional food preparers than by women, persons 30 years old or older, and frequent food preparers. Respondents who identified a food vehicle for Salmonella spp. were more likely to report washing their hands and cleaning cuttings boards after preparing raw meat and poultry. The results raise concerns about consumer food-handling practices. The influence of food safety training, food-handling experience, and age on food-handling practices should be studied further. Awareness of a food vehicle for Salmonella spp., for example, may indicate knowledge of the etiology of foodborne disease that promotes safe food handling. Understanding the factors associated with safe food handling will assist in development of effective safe-food instruction programs.
KW - biodeterioration
KW - food preparation
KW - food safety
KW - foodborne diseases
KW - foods
KW - health hazards
KW - knowledge
KW - microbial contamination
KW - pathogens
KW - USA
KW - salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Food Processing (General) (QQ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961301557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recalls of foods and cosmetics by the U.S. Food and Drug Administration.
AU - Venugopal, R.
AU - Tollefson, L.
AU - Hyman, F. N.
AU - Timbo, B.
AU - Joyce, R. E.
AU - Klontz, K. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 8
SP - 876
EP - 880
SN - 0362-028X
AD - Venugopal, R.: Epidemiology Branch, HFS-728, Division of Market Studies, U.S. Food and Drug Administration, 200 C Street, S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19971409381. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition
N2 - Foods and cosmetics recalled by industry and the US Food and Drug Administration (FDA) from 1 October 1991 to 30 September 1992 were reviewed to determine the kinds of products recalled and the reasons for recall. A total of 230 recalls, involving 569 foods and cosmetics, occurred during the study period. 28% of recalls were designated class I, defined as a situation in which there is a reasonable probability that the use of, or exposure to, a violative product will cause serious adverse health consequences. The problems for which foods or cosmetics were most often recalled were misbranding and microbial contamination (37 and 25% of recalls, respectively). A recognized illness or injury was reported to have occurred in association with 32 food products and 1 cosmetic. It was concluded that recalls of foods and cosmetics are common and that various groups, including industry, consumers, state regulatory agencies and the FDA, recognize problems leading to recall.
KW - botulism
KW - cosmetics
KW - food contamination
KW - food poisoning
KW - foods
KW - legislation
KW - microbial contamination
KW - public health
KW - USA
KW - listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a selective enrichment most probable number enumeration method for viable Listeria spp. in dairy products.
AU - Tran, T. T.
AU - Hitchins, A. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 9
SP - 928
EP - 931
SN - 0362-028X
AD - Tran, T. T.: Division of Microbiological Studies, U.S. Food and Drug Administration, 200 C Street S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19960404618. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - A most probable number (MPN) method for enumerating low numbers of Listeria spp. in milk products was developed by adapting the US Food and Drug Administration (FDA) Listeria isolation methodology. Pasteurized milk, 15 varieties of cheese, ice cream and dried milk were diluted and homogenized in enrichment broth (1 g/10 ml). Homogenates were inoculated with L. monocytogenes Lm82, a streptomycin-resistant variant of strain Scott A, at <1 to 320 cfu/g and further diluted in FDA enrichment broth to give 0.1, 0.01 and 0.001 g milk sample/10 ml. Dilution aliquots (10 ml) were incubated at 30°C for 48 h before being subcultured on Oxford agar at 35°C. Esculin-hydrolysing colonies on Oxford agar were confirmed as the inoculum strain by their ability to grow on trypticase soya agar containing streptomycin. Differences between inoculum and MPN values were evaluated using tabulated 95% confidence limits. The calculated MPN agreed with the inoculum levels in 91% (58 of 64) of the milk products except the cheeses and in 49% (56 of 112) of the cheeses. Competitive microflora affected by cheese age and the type of milk used in their manufacture may account for the suboptimal performance of the MPN method for the cheeses.
KW - analytical methods
KW - cheeses
KW - detection
KW - dried milk
KW - enrichment
KW - enumeration
KW - ice cream
KW - milk products
KW - pasteurized milk
KW - Listeria
KW - Listeria monocytogenes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - analytical techniques
KW - bacterium
KW - dairy products
KW - milk powder
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960404618&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Atypical toxigenic Staphylococcus and non-Staphylococcus aureus species on the horizon? An update.
AU - Bennett, R. W.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 10
SP - 1123
EP - 1126
SN - 0362-028X
AD - Bennett, R. W.: Division of Microbiological Studies, U.S. Food and Drug Administration, 200 C Street, S.W., Washington D.C. 20204, USA.
N1 - Accession Number: 19970400437. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - This study reviews earlier observations of non-S. aureus species of staphylococci associated with food contamination and their possible incrimination in foodborne outbreaks. It presents evidence showing the inability of ancillary identification tests to predict the potential enterotoxigenicity of staphylococcal isolates, profiles an outbreak not typically caused by S. aureus (S. intermedius in butter and margarine), and underscores the analytical precautions that may be taken to resolve problems associated with staphylococcal foodborne illness.
KW - analytical methods
KW - butter
KW - enterotoxins
KW - food contamination
KW - food poisoning
KW - foodborne diseases
KW - foods
KW - margarine
KW - microbial contamination
KW - Staphylococcus
KW - Staphylococcus aureus
KW - Staphylococcus intermedius
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Staphylococcus
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Crop Produce (QQ050)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970400437&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Production and characterization of monoclonal antibodies to detect Vibrio cholerae serogroup O1 in a rapid enzyme-linked immunosorbent assay.
AU - Noah, C. W.
AU - Poteet, S. S.
AU - Lister, M. M.
AU - Roderick, C. N.
AU - Smith, D. B.
AU - Colvert, R. M.
AU - Holland, M. A.
AU - Cerniglia, C. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1996///
VL - 59
IS - 11
SP - 1153
EP - 1157
SN - 0362-028X
AD - Noah, C. W.: Dallas District Office, U.S. Food and Drug Administration, 3032 Bryan St., Dallas, Texas 75204, USA.
N1 - Accession Number: 19971402604. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Tropical Diseases
N2 - Monoclonal antibodies (MAbs) were developed for a rapid and efficient screening procedure to detect cultures of Vibrio cholerae serogroup O1. Spleen cells of BALB/c mice previously immunized with an attenuated control strain of V. cholerae were fused with mouse myeloma cell line SP2/0. An enzyme-linked immunosorbent assay (ELISA) was used to test cultural hybridoma secretions of 2 MAbs against 120 strains of V. cholerae O1, 38 strains of V. cholerae non-O1, 15 strains of other Vibrio spp., and 20 strains of other bacterial species. Results of tests using both MAbs were identical. The MAbs successfully detected all of the confirmed serotype O1 strains. 3 additional V. cholerae strains that agglutinated antisera and the saline control were considered serologically inconclusive. Of these, 1 was detected as positive for V. cholerae by both MAbs. The MAbs gave no false-positive reactions when tested against the confirmed non-O1 strains, other Vibrio spp. and other bacterial species. Use of this ELISA will enhance the speed and accuracy needed for detecting V. cholerae O1 cultures.
KW - analytical methods
KW - cholera
KW - detection
KW - elisa
KW - monoclonal antibodies
KW - mice
KW - Vibrio cholerae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - Techniques and Methodology (ZZ900)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402604&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria.
AU - Lal, A. A.
AU - Hughes, M. A.
AU - Oliveria, D. A.
AU - Nelson, C.
AU - Bloland, P. B.
AU - Oloo, A. J.
AU - Hawley, W. E.
AU - Hightower, A. W.
AU - Nahlen, B. L.
AU - Udhayakumar, V.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1996///
VL - 64
IS - 3
SP - 1054
EP - 1059
SN - 0019-9567
AD - Lal, A. A.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19960803313. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - The immunodominant T-cell determinants in the Plasmodium falciparum AMA-1 antigen were mapped using synthetic peptides. From the amphipathic scores, 17 putative T-cell determinants were identified. Nine of the 17 peptides complementary to the putative T-cell determinants induced proliferation of peripheral blood mononuclear cells (PBMC) from Kenyan residents who had lifelong exposure to malaria; none of these peptides included proliferation of PBMC from donors who were not previously exposed to malaria. This indicates that AMA-1 peptides were stimulating T cells that were previously primed by prior exposure to P. falciparum. Many positive responders showed reactivity to more than one peptide, and some of the potent proliferative T epitopes were found to be localized in the highly conserved regions of AMA-1, suggesting that it may be possible to induce T-cell memory that can recognize different variant forms of the parasite. This information on the natural immune responses against the AMA-1 vaccine antigen in clinically immune adults will be helpful in the development of an AMA-1 antigen-based malaria vaccine and may also guide testing of AMA-1-based vaccine formulations.
KW - antigens
KW - epitopes
KW - human diseases
KW - immune response
KW - malaria
KW - parasites
KW - peptides
KW - T lymphocytes
KW - Africa
KW - Kenya
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - AMA-1
KW - antigenic determinants
KW - antigenicity
KW - apical membrane antigens
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - T cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960803313&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Minimal requirements for murine resistance to infection with Francisella tularensis LVS.
AU - Elkins, K. L.
AU - Rhinehart-Jones, T. R.
AU - Culkin, S. J.
AU - Yee, D.
AU - Winegar, R. K.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1996///
VL - 64
IS - 8
SP - 3288
EP - 3293
SN - 0019-9567
AD - Elkins, K. L.: Laboratory of Enteric and Sexually Transmitted Diseases, Division of Bacterial Products, Center for Biologics Evaluation and Research, 1401 Rockville Pike, HFM 440, Bethesda, MD 20852, USA.
N1 - Accession Number: 19970500225. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - Intraperitoneal or intravenous infection of mice with F. tularensis LVS is lethal, with an intraperitoneal LD50 approaching a single bacterium. Intradermal (i.d.) LVS infection has a much higher LD50, about 106 bacteria in BALB/cByJ mice, and survival of i.d. infection leads to solid generation of immunity against lethal challenge. To define the minimal requirements for both initial and long-term survival of i.d. infection, the authors characterized the nature of i.d. LVS infection in lymphocyte-deficient BALB/cByJ scid mice. scid mice infected i.d. with strain LVS survived for about 20 days and then died from overwhelming disseminated infection. However, scid mice treated with monoclonal antibodies to γ-interferon, tumour necrosis factor-α or neutrophils-granulocytes all died within 1 week of infection, indicating that these were essential for early control of infection. Studies using GKO (gamma interferon knockout) mice emphasized that γ-interferon is absolutely required for initial survival of i.d. LVS infection. scid mice could be reconstituted for long-term survival of i.d. LVS infection and clearance of bacteria by intravenous transfer of splenic lymphocytes or purified B220-/T+ lymphocytes but not nu/nu lymphocytes. T cells were therefore required for long-term clearance and survival of i.d. LVS infection: efforts to determine whether CD4+ T cells, CD8+ T cells or both are involved are ongoing.
KW - immune response
KW - immunity
KW - interferon
KW - laboratory animals
KW - T lymphocytes
KW - tularaemia
KW - tumour necrosis factor
KW - Francisella
KW - Francisella tularensis
KW - mice
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Francisella
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - cachectin
KW - cachexin
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - tularemia
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970500225&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contributions of food groups to estimated intakes of nutritional elements: results from the FDA total diet studies, 1982-1991.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
JO - International Journal for Vitamin and Nutrition Research
JF - International Journal for Vitamin and Nutrition Research
Y1 - 1996///
VL - 66
IS - 4
SP - 342
EP - 349
SN - 0300-9831
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, SW.,Washington, DC 20204, USA.
N1 - Accession Number: 19971402375. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7440-70-2, 7440-50-8, 7553-56-2, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6. Subject Subsets: Human Nutrition; Dairy Science
N2 - The contributions of 12 food groups to the estimated dietary intakes of 11 nutritional elements in the diets of 8 age-sex groups was estimated from analyses of 234 core foods in the US food supply and consumption data from national food consumption surveys. The major contributors of each element were grain products for sodium, iron, manganese and iodine; vegetables for potassium; milk and cheese for calcium; milk and cheese and animal flesh for phosphorus; vegetables and grain products for magnesium; and animal flesh for zinc, copper, and selenium. For the infant diet, the milk and cheese group (which included infant formula) was the major contributor to the estimated intakes of Na, K, Ca, P, Mg, Zn, Cu and I. Grain products were the primary sources for Fe, Mn and Se in the infant diet. The diet of 2-year-olds, which included a considerable amount of milk, contained larger percentages of Na, K, Ca, P, Mg, Zn and I from milk and cheese than do the diets of older age-sex groups. For teenagers, milk and cheese made a greater contribution to K, Ca, P, Mg, Zn, Mn and I intakes than they do for the adult age-sex groups.
KW - adolescents
KW - adults
KW - age
KW - animal products
KW - calcium
KW - cheeses
KW - children
KW - copper
KW - diet studies
KW - food consumption
KW - food groups
KW - grain crops
KW - infant formulae
KW - infants
KW - intake
KW - iodine
KW - iron
KW - magnesium
KW - manganese
KW - milk
KW - milk products
KW - minerals
KW - phosphorus
KW - potassium
KW - selenium
KW - sex differences
KW - sodium
KW - sources
KW - trace elements
KW - zinc
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - infant formula
KW - infant formulas
KW - microelements
KW - Mn
KW - teenagers
KW - United States of America
KW - Diet Studies (VV110)
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402375&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total diet study: estimated dietary intakes of nutritional elements, 1982-1991.
AU - Pennington, J. A. T.
AU - Schoen, S. A.
JO - International Journal for Vitamin and Nutrition Research
JF - International Journal for Vitamin and Nutrition Research
Y1 - 1996///
VL - 66
IS - 4
SP - 350
EP - 362
SN - 0300-9831
AD - Pennington, J. A. T.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, SW., Washington, DC 20204, USA.
N1 - Accession Number: 19971402376. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 7440-70-2, 7440-50-8, 7553-56-2, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-66-6. Subject Subsets: Human Nutrition
N2 - Dietary intakes of 11 nutritional elements for 8 age-sex groups were estimated for 1982-1991 on the basis of results from laboratory analyses of 234 core foods of the US food supply and food consumption data from 2 national food consumption surveys conducted in late 1970. Estimated intakes based on the mean and median (50th percentile) levels of the elements in the foods were similar, except for iodine for which intake estimates based on mean values exceeded those based on median values. High concentrations of I in some foods resulted in increased mean, compared with median, values. Estimated intakes of sodium, potassium, phosphorus, selenium and I met or nearly met dietary intake standards set by the National Academy of Sciences (NAS). Estimated intakes of copper were below NAS standards for all 8 age-sex groups. Estimated intakes were below NAS standards for magnesium for 6 age-sex groups, calcium and zinc for 5 age-sex groups, iron for 3 age-sex groups and manganese for one age-sex group. The diets of teenage girls had 7 elements below NAS standards, the diets of adult women had 5 elements below NAS standards and the diets of 2-year-olds and older men and women had 4 elements each below NAS standards. The estimated intake of Na for 6-11-month-old infants showed a decreasing trend from 729 mg/day in 1982/83 to 632 mg/day in 1990/91. There were no other significant trends or changes in estimated element intakes over the 9-year period.
KW - adolescents
KW - adults
KW - age
KW - calcium
KW - children
KW - consumption
KW - copper
KW - diet
KW - diet studies
KW - food consumption
KW - guidelines
KW - infants
KW - iodine
KW - iron
KW - magnesium
KW - manganese
KW - minerals
KW - phosphorus
KW - potassium
KW - recommended dietary allowances
KW - selenium
KW - sex differences
KW - sodium
KW - trace elements
KW - trends
KW - zinc
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - microelements
KW - Mn
KW - RDA
KW - recommendations
KW - recommended dietary intakes
KW - teenagers
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402376&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of sesame oil on serum and liver lipid profiles in the rat.
AU - Subramaniam Satchithanandam
AU - Chanderbhan, R.
AU - Kharroubi, A. T.
AU - Calvert, R. J.
AU - Klurfeld, D.
AU - Tepper, S. A.
AU - Kritchevsky, D.
JO - International Journal for Vitamin and Nutrition Research
JF - International Journal for Vitamin and Nutrition Research
Y1 - 1996///
VL - 66
IS - 4
SP - 386
EP - 392
SN - 0300-9831
AD - Subramaniam Satchithanandam: Division of Science and Applied Technology, US Food and Drug Administration, MOD-1, 8301 Muirkirk Road, Laurer, MD 20708, USA.
N1 - Accession Number: 19971402380. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 60-33-3, 8008-74-0. Subject Subsets: Human Nutrition
N2 - The effect of sesame oil on serum cholesterol concentrations were examined in 3 groups of male Wistar rats (75-100 g) fed on a standard laboratory diet or a diet containing 12 or 24% sesame oil. To increase serum cholesterol concentrations, 1% cholesterol and 0.5% cholic acid were also added to each diet. After 4 weeks of feeding, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride concentrations were estimated in the serum. Liver weight and cholesterol and triacylglycerol concentrations were also estimated. Liver cholesterol concentrations were significantly decreased in rats fed on the 24% sesame oil diet, while liver lipid concentration was significantly increased in the 24% sesame oil-fed group compared with the control group. Liver weights and esterified cholesterol and liver triacylglycerol concentrations did not differ significantly between the groups. Concentrations of serum total cholesterol and LDL-cholesterol were significantly decreased in rats fed the 24% sesame oil diet compared with the control group. Serum triacylglycerol and HDL-cholesterol concentrations did not differ significantly between the groups.
KW - blood
KW - cholesterol metabolism
KW - diets
KW - high density lipoprotein
KW - intake
KW - linoleic acid
KW - lipid metabolism
KW - liver
KW - low density lipoprotein
KW - sesame oil
KW - triacylglycerols
KW - unsaturated fats
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fat metabolism
KW - triglycerides
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402380&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and confirmation of β-agonists in bovine retina using LC/APCI-MS.
AU - Doerge, D. R.
AU - Churchwell, M. I.
AU - Holder, C. L.
AU - Rowe, L.
AU - Bajic, S.
JO - Analytical Chemistry (Washington)
JF - Analytical Chemistry (Washington)
Y1 - 1996///
VL - 68
IS - 11
SP - 1918
EP - 1923
SN - 0003-2700
AD - Doerge, D. R.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19962209919. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 21898-19-1, 37148-27-9. Subject Subsets: Veterinary Science; Veterinary Science; Animal Nutrition
N2 - On-line liquid chromatography with atmospheric pressure chemical ionization mass spectrometry (LC/APCI-MS) was used for sensitive detection of several β-agonists in retina. Multiresidue extraction, separation, detection, and confirmation procedures were developed for retinal tissue and applied to eyes from cattle treated with clenbuterol (69-201 ppb) and to control eyes spiked with salbutamol (100 ppb) and terbutaline (25-100 ppb). Rapid switching of the potential difference between sampling cone and skimmer in the transport region of the API source was used to optimize acquisition of the protonated molecules and characteristic fragment ions obtained by collision-induced dissociation reactions. The respective selected ions were simultaneously acquired using a single quadrupole mass spectrometer. The accurate and precise agreement observed for diagnostic ion intensity ratios between β-agonists in retinal samples and authentic standards suggests that LC/APCI-MS can be used for confirmation of analyte structure at trace levels and does not require the use of a triple-stage quadrupole mass analyser.
KW - analytical methods
KW - assays
KW - beta-adrenergic agonists
KW - clenbuterol
KW - drug residues
KW - growth promoters
KW - liquid chromatography
KW - mass spectrometry
KW - poisoning
KW - residues
KW - retina
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - growth stimulants
KW - salbutamol
KW - terbutaline
KW - toxicosis
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962209919&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Brucella abortus conjugated with a peptide derived from the V3 loop of human immunodeficiency virus (HIV) type 1 induces HIV-specific cytotoxic T-cell responses in normal and in CD4+ cell-depleted BALB/c mice.
AU - Lapham, C.
AU - Golding, B.
AU - Inman, J.
AU - Blackburn, R.
AU - Manischewitz, J.
AU - Highet, P.
AU - Golding, H.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1996///
VL - 70
IS - 5
SP - 3084
EP - 3092
SN - 0022-538X
AD - Lapham, C.: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19962007475. Publication Type: Journal Article. Language: English. Number of References: 37 ref.
KW - animal models
KW - conjugate vaccines
KW - cytotoxic T lymphocytes
KW - envelope protein gp120
KW - HIV-1 infections
KW - human diseases
KW - immune response
KW - immunization
KW - peptides
KW - vaccines
KW - Brucella abortus
KW - Human immunodeficiency virus 1
KW - man
KW - mice
KW - Brucella
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - bacterium
KW - gp120
KW - human immunodeficiency virus type 1
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - V3 loop
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007475&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid determination of the total trans content of neat hydrogenated oils by attenuated total reflection spectroscopy.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - McDonald, R. E.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1996///
VL - 73
IS - 8
SP - 1003
EP - 1009
SN - 0003-021X
AD - Mossoba, M. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204.
N1 - Accession Number: 19961410763. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
N2 - A Fourier transform infrared spectroscopy procedure is described for quantitating the levels of total trans triglycerides or their fatty acid methyl ester derivatives in neat fats and oils. It requires warming or no preparation of the laboratory sample, and about 5 min for spectroscopic measurement, band area integration, and calculation of the trans content from a linear regression equation. To eliminate the strongly sloping background of the 966-cm-1trans band, the single-beam spectrum of the trans-containing fat is "ratioed" against that of an unhydrogenated oil or a reference material that contains only cis double bonds. Thus, a symmetric absorption band on a horizontal background is obtained. The area under the trans band can then be accurately integrated between the same limits, 990 and 945 cm-1, for all trans levels investigated. To speed up the analysis, an attenuated total reflection liquid cell was used, into which oils, melted fats or their methyl esters were poured without weighing or quantitative dilution with the toxic and volatile carbon disulfide solvent. The trans levels determined by attenuated total reflection were closer to those found by capillary gas chromatography when the hydrogenated fat was measured against the corresponding unhydrogenated oil than when it was measured against a cis reference material. Small differences were found between trans levels in hydrogenated fat test samples and the corresponding methyl ester derivatives (9.3 and 2.2% at about 2 and 41% trans, respectively). The lower limits of identification and quantitation were 0.2 and 1%, respectively.
KW - analytical methods
KW - hydrogenated fats
KW - hydrogenated oils
KW - reflection
KW - spectroscopy
KW - trans fatty acids
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410763&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Singlet oxygen oxidation of lipids resulting from photochemical sensitizers in the presence of antioxidants.
AU - Yasaei, P. M.
AU - Yang, G. C.
AU - Warner, C. R.
AU - Daniels, D. H.
AU - Yuoh Ku
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1996///
VL - 73
IS - 9
SP - 1177
EP - 1181
SN - 0003-021X
AD - Yasaei, P. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19961410850. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - Singlet oxygen produced by photochemical sensitizers may play an important role in the oxidation of lipids in foods. Therefore, singlet oxygen oxidation of lipids and the scavenging ability of antioxidants were examined. Singlet oxygen was generated using the photosensitizer rose bengal. The oxidation products of lipids and antioxidants were separated by HPLC and monitored using post-column chemiluminescence and/or iodometric detection. The competitive reaction rates of various antioxidants and lipids were studied to elucidate the roles played by antioxidants in the prevention of food oxidation by singlet oxygen.
KW - antioxidants
KW - foods
KW - lipid peroxidation
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410850&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total trans fatty acids in foods: comparison of capillary-column gas chromatography and single-bounce horizontal attenuated total reflection infrared spectroscopy.
AU - Ali, L. H.
AU - Angyal, G.
AU - Weaver, C. M.
AU - Rader, J. I.
AU - Mossoba, M. M.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1996///
VL - 73
IS - 12
SP - 1699
EP - 1705
SN - 0003-021X
AD - Ali, L. H.: Office of Food Labeling, (HFS-175), Food and Drug Administration, 200 C. St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19971404893. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 8001-22-7. Subject Subsets: Human Nutrition
N2 - The total trans fatty acid content of 18 food products was determined, after acid hydrolysis, extraction and methylation of fatty acids, by gas chromatography with a polar 100% cyanopropylsiloxane capillary column and by single-bounce horizontal attenuated total reflection spectroscopy (SB-HATR). The trans fatty acid methyl esters (FAME) of 9-hexadecenoate (9t-16:1), 9-octadecenoate (9t-18:1) and 9,12-octadecadienoate (9t, 12t-18:2) were identified by comparison of their retention times with those of known standards and quantitated. The isomers c,t- and t,c-18:2 were identified from their published retention times and included in the quantitation of trans FAME. Neat 50-µL portions of the FAME that were used for gas-chromatographic analysis also were analysed by SB-HATR. This technique requires neither weighing nor quantitative dilution of test portions prior to spectroscopic quantitation of isolated double bonds of trans configuration. A symmetric 966-cm-1 absorption band on a horizontal background was obtained from unhydrogenated soyabean oil FAME as the reference material. For 9 of 11 products with trans fat content >5% of total fat, results obtained by SB-HATR were higher than those obtained by gas chromatography. Results obtained by the gas-chromatographic procedure were slightly to significantly higher than those obtained by SB-HATR for the 6 foods in which trans fat content was <5% of total fat.
KW - estimation
KW - fatty acids
KW - foods
KW - gas chromatography
KW - infrared spectroscopy
KW - soyabean oil
KW - trans fatty acids
KW - soybean oil
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404893&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perinatal mortality in rural Malawi.
AU - McDermott, J.
AU - Steketee, R.
AU - Wirima, J.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1996///
VL - 74
IS - 2
SP - 165
EP - 171
SN - 0042-9686
AD - McDermott, J.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19972008135. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 17 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - Reported are the results of a study to assess the prevalence and risk factors for perinatal death among pregnant women in Malawi over the period 1987-90. There were 264 perinatal deaths among the 3866 women with singleton pregnancies (perinatal mortality rate, 68.3 per 1000 births). Among the risk factors for perinatal mortality were the following: reactive syphilis serology, nulliparity, a late fetal or neonatal death in the most recent previous birth, maternal height <150 cm, home delivery, and low socioeconomic status. Although unexplained perinatal deaths will continue to occur, perinatal mortality can be reduced if its causes and risk factors in a community are given priority in antenatal and intrapartum care programmes. The following interventions could potentially reduce the perinatal mortality in the study population: screening and treating women with reactive syphilis serology; and management from early labour, by competent personnel in a health facility, of nulliparous women and multiparous women who are short or have a history of a perinatal death.
KW - fetal death
KW - infants
KW - mortality
KW - mothers
KW - neonates
KW - parturition
KW - perinatal mortality
KW - puerperium
KW - risk factors
KW - rural development
KW - Africa
KW - Malawi
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - death rate
KW - foetal death
KW - newborn infants
KW - Nyasaland
KW - postnatal period
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008135&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modeling residue uptake by eggs. 1. Similar drug residue patterns in developing yolks following injection with ampicillin or oxytetracycline.
AU - Donoghue, D. J.
AU - Hairston, H.
AU - Gaines, S. A.
AU - Bartholomew, M. J.
AU - Donoghue, A. M.
JO - Poultry Science
JF - Poultry Science
Y1 - 1996///
VL - 75
IS - 3
SP - 321
EP - 328
SN - 0032-5791
AD - Donoghue, D. J.: Pharmacology and Biochemistry Branch, Building 328-A, Agricultural Research Center, Center for Veterinary Medicine, Food and Drug Administration, Beltsville, Maryland 20705, USA.
N1 - Accession Number: 19962210096. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 79-57-2. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Veterinary Science; Poultry
N2 - In 2 separate experiments, 16 hens were divided into equal groups (n=8) and injected with either 400 mg/kg ampicillin or 200 mg/kg oxytetracycline (OTC; total hens=32) approximately 1 h after oviposition. 24 h following injections, hens were killed and the ovaries collected. Individual large yellow yolks (≥0.2 g) and a pool of 5 small yellow yolks (<0.2 g) were collected for determination of ampicillin or OTC content. Combined results from experiments 1 and 2 indicated that short-term drug exposure in hens caused incorporation of drug residues in developing yolks (days to weeks from being ovulated) in a specific, drug independent pattern. Drug residues were greater (total µg content) in some of the less mature yolks than in the largest preovulatory yolk. This may lead to a sequential release of eggs with increasing residue content, even after drug withdrawal. These data were used to construct a model to predict the patterns of incurred residues in formed eggs following exposure of hen to drugs or other contaminants.
KW - ampicillin
KW - antibiotics
KW - drug residues
KW - egg yolk
KW - eggs
KW - food contamination
KW - hens
KW - models
KW - ovaries
KW - oxytetracycline
KW - poultry
KW - USA
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - terramycin
KW - United States of America
KW - yolk
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Eggs and Egg Products (QQ040)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962210096&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interactions in indices of vitamin A, zinc and copper status when these nutrients are fed to rats at adequate and increased levels.
AU - Sundaresan, P. R.
AU - Kaup, S. M.
AU - Wiesenfeld, P. W.
AU - Chirtel, S. J.
AU - Hight, S. C.
AU - Rader, J. I.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 1996///
VL - 75
IS - 6
SP - 915
EP - 928
SN - 0007-1145
AD - Sundaresan, P. R.: Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, SC 20204, USA.
N1 - Accession Number: 19961407174. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 57-88-5, 7440-50-8, 68-26-8, 7440-66-6. Subject Subsets: Human Nutrition
N2 - The effects of feeding nutritionally adequate and increased levels of vitamin A (retinyl acetate (RA) 1.4, 34.4 and 206.4 mg/kg diet) in combination with adequate or increased zinc (12 and 240 mg/kg) and copper (5 and 50 mg/kg) on serum and tissue concentrations of retinol and retinyl palmitate (RP) and on indices of Cu and Zn status were examined in female Sprague-Dawley rats. Rats fed on diets containing RA 34.4 and 206.4 mg/kg had higher food intakes and relative liver weights than those fed on diets containing RA 1.4 mg/kg. An interaction between dietary Cu and Zn and an independent effect of vitamin A affected serum ceruloplasmin oxidase (EC 1.16.3.1) activity. Rats fed on high Zn, adequate-Cu diets (Zn 240 and Cu 5 mg/kg, respectively) had lower serum ceruloplasmin oxidase levels than rats fed on adequate-Zn, adequate-Cu diets (Zn 12 and Cu 5 mg/kg, respectively). This effect was not observed in rats fed on high-Zn, high-Cu diets (Zn 240 and Cu 50 mg/kg, respectively). Alterations in dietary levels of Cu and vitamin A independently affected haemoglobin levels. Serum cholesterol concentration was affected by interactions between Zn and vitamin A and Cu and vitamin A. Levels of retinol and RP in liver and kidney were significantly higher in rats fed on diets with increased dietary vitamin A than in those fed on diets with adequate vitamin A. Three-way interactions among Cu, Zn and vitamin A affected levels of retinol in serum and liver. Two-way interactions between Cu and vitamin A affected liver RP and the sum of liver retinol + RP. An independent effect of dietary Zn on these variables was also observed. Interactions between Cu and vitamin A affected levels of Cu in liver and kidney, while Fe and Zn in kidney were affected by interactions between Cu and Zn. The results indicate that differing interactions among variables of vitamin A metabolism and mineral status occur with higher dietary levels of vitamin A, Zn and Cu in the rat.
KW - blood
KW - cholesterol
KW - copper
KW - interactions
KW - kidneys
KW - liver
KW - nutrients
KW - retinol
KW - trace elements
KW - vitamins
KW - zinc
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - axerophthol
KW - ceruloplasmin oxidase
KW - microelements
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961407174&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Population genetics with RAPD-PCR markers: the breeding structure of Aedes aegypti in Puerto Rico.
AU - Apostol, B. L.
AU - Black, W. C., IV
AU - Reiter, P.
AU - Miller, B. R.
JO - Heredity
JF - Heredity
Y1 - 1996///
VL - 76
IS - 4
SP - 325
EP - 334
SN - 0018-067X
AD - Apostol, B. L.: Medical Entomology and Ecology Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2987, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19960502689. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - RAPD-PCR polymorphisms at 57 presumptive loci were used to examine the breeding structure of A. aegypti in Puerto Rico. Mosquitoes were sampled from 16 locations in 6 cities and samples were located in a nested spatial design to examine local patterns of gene flow. Allele frequencies were estimated assuming (1) that genomic regions amplified by RAPD-PCR segregate as dominant alleles, (2) that genotypes at RAPD loci are in Hardy-Weinberg proportions, (3) identity in state (iis) among dominant amplified alleles, and (4) iis among null alleles. The average genic heterozygosity was 0.354, more than twice the level detected in earlier allozyme surveys. Nested analysis of variance indicated extensive genetic differentiation among locations within cities. Effective migration rates (Nm) among cities were estimated from FST assuming an island model of migration. Estimates of Nm ranged from 9.7 to 12.2, indicating a high dispersal rate. The large number of polymorphisms revealed by RAPD-PCR allowed the distribution of FST and linkage disequilibrium to be examined among loci and demonstrated that small samples inflate FST and linkage disequilibrium. No linkage disequilibrium maintained through epistasis was detected among alleles at the 57 loci.
KW - dispersal
KW - genetics
KW - linkage
KW - markers
KW - migration
KW - polymerase chain reaction
KW - population ecology
KW - population genetics
KW - random amplified polymorphic DNA
KW - urban areas
KW - Puerto Rico
KW - Aedes aegypti
KW - Culicidae
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - mosquitoes
KW - PCR
KW - Porto Rico
KW - RAPD
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960502689&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The zoonotic importance of Mycobacterium bovis.
AU - Moda, G.
AU - Daborn, C. J.
AU - Grange, J. M.
AU - Cosivi, O.
JO - Tubercle and Lung Disease
JF - Tubercle and Lung Disease
Y1 - 1996///
VL - 77
IS - 2
SP - 103
EP - 108
SN - 0962-8479
AD - Moda, G.: Veterinary Public Health Service, Piedmont Region, Torino, Italy.
N1 - Accession Number: 19962208928. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 33 ref. Subject Subsets: Veterinary Science; Public Health
N2 - The zoonotic importance of Mycobacterium bovis has been the subject of renewed interest in the wake of the increasing incidence of tuberculosis in the human population. This paper considers some of the conditions under which transmission of M. bovis from animals to humans occurs and reviews current information on the global distribution of the disease. The paper highlights the particular threat posed by this zoonotic disease in developing countries and lists the veterinary and human public health measures that need to be adopted if the disease is to be contained. The association of tuberculosis with malnutrition and poverty has long been recognized and the need to address these basic issues are as crucial as specific measures against the disease itself.
KW - cattle diseases
KW - disease transmission
KW - infections
KW - public health
KW - reviews
KW - tuberculosis
KW - zoonoses
KW - cattle
KW - man
KW - Mycobacterium bovis
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962208928&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stage-specific expression of a Plasmodium falciparum protein related to the eukaryotic mitogen-activated protein kinases.
AU - Lin, D. T.
AU - Goldman, N. D.
AU - Syin, C.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1996///
VL - 78
IS - 1/2
SP - 67
EP - 77
SN - 0166-6851
AD - Lin, D. T.: Laboratory of Parasitic Biology and Biochemistry, Division of Allergenic Products and Parasitology, Office of Vaccine Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-416, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19960805246. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9026-43-1. Subject Subsets: Protozoology
N2 - A putative protein kinase gene was identified from both Plasmodium falciparum cDNA and genomic DNA libraries. The nucleotide sequence contains an open-reading frame of 2646 bp, which codes for a predicted protein of 882 amino acid residues. Comparison of the predicted amino acid sequence with those in GenBank suggests that this gene codes for a protein similar to the mitogen-activated protein (MAP) kinase of other organisms. This MAP kinase-related protein, named PfMRP, contains the TDY dual phosphorylation site upstream of the highly conserved VATRWYRAPE sequence in subdomain VIII. PfMRP contains an unusually large and highly charged domain within its carboxyl-terminal segment, which includes 2 repetitive sequences of either a tetrapeptide or octapeptide motif. The PfMRP gene is located on chromosome 14. Northern blot analysis of total RNA revealed the presence of a single mRNA transcript ~4.2 kb in length, which is predominantly expressed in gametocytes and gametes/zygotes.
KW - amino acid sequences
KW - enzymes
KW - gene expression
KW - genes
KW - molecular genetics
KW - parasites
KW - protein kinase
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805246&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cloning of a Plasmodium falciparum gene related to the human 60-kDa heat shock protein.
AU - Chiang Syin
AU - Goldman, N. D.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1996///
VL - 79
IS - 1
SP - 13
EP - 19
SN - 0166-6851
AD - Chiang Syin: Laboratory of Parasitic Biology and Biochemistry, Division of Allergenic Products and Parasitology, Office of Vaccine Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-416, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19960804230. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - A gene encoding the 60 000 MW heat shock protein (hsp60) was identified from a Plasmodium falciparum (clone 3D7) blood stage cDNA library. The deduced protein sequence encodes a polypeptide of 577 amino acids with a calculated MW of 62 158. The primary structure of P. falciparum hsp60 contains a putative mitochondrial targeting peptide at its amino-terminus and a GGM motif at its carboxyl-terminus. The overall structure exhibits strong conservation (~50%) to the hsp60 from human and other eukaryotes, but only low homology (<30%) to a recently reported P. falciparum chaperonin 60 gene. The P. falciparum hsp60 gene is located on chromosome 10. During heat shock, the level of hsp60 transcript in blood stage parasites increases significantly and its accumulation correlates with the duration of the induction.
KW - amino acid sequences
KW - genes
KW - heat shock proteins
KW - molecular genetics
KW - parasites
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960804230&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of multiple tetracycline residues in milk by metal chelate affinity chromatography: collaborative study.
AU - Carson, M. C.
AU - Breslyn, W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 1
SP - 29
EP - 42
SN - 1060-3271
AD - Carson, M. C.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Division of Residue Chemistry, Beltsville, MD 20705, USA.
N1 - Accession Number: 19960401785. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 79-57-2. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science
N2 - In order to meet USA federal and state regulatory needs, a liquid chromatographic (LC) method with ultraviolet detection was developed for determination of 7 tetracyclines at 30 ng/ml in milk. Raw milk samples are defatted, acidified and centrifuged to remove proteins, and tetracyclines are specifically absorbed from the milk by chelation with metal ions bound to small Chelating Sepharose Fast-Flow columns. Tetracyclines are removed from these columns with EDTA-containing buffer, and extracts are further cleaned by ultrafiltration. Finally, extracts are concentrated and analysed simultaneously by using on-line concentration. This method was validated in a collaborative study that involved 11 laboratories, including the authors' laboratory. Each laboratory was asked to prepare and analyse known control and fortified milk samples, as well as 18 coded-blind samples. Eight laboratories completed all analyses. Average interlaboratory recoveries for the known fortified samples ranged from 59% (methacycline at 15 ng/ml) to 78% (oxytetracycline at 60 ng/ml). Average recovery for each of 7 residues at 30 ng/ml were between 60 and 110%, meeting single-residue guidelines for accuracy set by the US. Food and Drug Administration. Reproducibility relative s.d. (RSDr) for the known fortified samples varied from 11 to 39%, with 6 of 7 residues at the 30 ng/ml level having RSDr values at or <20%. Seven of 8 laboratories correctly identified blind control milk samples and all 28 residues present in blind samples. The metal chelate affinity-LC method for determination of multiple tetracycline residues in milk has been adopted first action by AOAC International.
KW - analytical methods
KW - antibiotics
KW - chromatography
KW - detection
KW - drug residues
KW - milk
KW - milk testing
KW - oxytetracycline
KW - raw milk
KW - tetracyclines
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - terramycin
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - History of the Food and Drug Administration's Total Diet Study (Part II), 1987-1993.
AU - Pennington, J. A. T.
AU - Capar, S. G.
AU - Parfitt, C. H.
AU - Edwards, C. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 1
SP - 163
EP - 170
SN - 1060-3271
AD - Pennington, J. A. T.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19961403974. Publication Type: Journal Article. Language: English. Number of References: 72 ref. Subject Subsets: Human Nutrition
N2 - The Total Diet Studies conducted by the US Food and Drug Administration (FDA) provide yearly information on levels of pesticide residues, contaminants and nutrients in the food supply and diets of specific age-sex groups. They also identify trends and changes in the levels of these substances in the food supply and in diets over time. Results are useful in making policy decision regarding the safety of the food supply, food additives, pesticide use, nutrient fortification and food labelling. This paper provides information on studies performed by FDA from 1987 to 1993.
KW - diet studies
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of amoxicillin in catfish and salmon tissues by liquid chromatography with precolumn formaldehyde derivatization.
AU - Ang, C. Y. W.
AU - Luo WenHong
AU - Hansen, E. B., Jr.
AU - Freeman, J. P.
AU - Thompson, H. C., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 2
SP - 389
EP - 396
SN - 1060-3271
AD - Ang, C. Y. W.: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Chemistry, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19962211466. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7. Subject Subsets: Veterinary Science; Veterinary Science
N2 - A liquid chromatographic (LC) method with fluorescence detection was developed for amoxicillin in catfish and salmon tissues. The tissue was extracted with phosphate buffer (pH 4.5), followed by trichloroacetic acid (TCA) precipitation of proteins and solid-phase (C18) extraction. Trace amounts of nonpolar interfering substances present after solid-phase extraction were removed by ether liquid-liquid extraction. The extract was reacted with formaldehyde and TCA at 100°C for 30 min. A fluorescent derivative was extracted with ether, concentrated, and analysed by reserved-phase LC with fluorescence detection. Average recoveries of amoxicillin spiked at 2.5-20 ppb were >80% for catfish and >75% for salmon muscle tissue, with coefficients of variation of <6%. Limits of detection (LOD) and quantitation (LOQ) for catfish tissue were 0.5 and 1.2 ppb, respectively. LOD and LoQ for salmon muscle tissue were 0.8 and 2.0 ppb, respectively.
KW - amoxicillin
KW - assays
KW - drug residues
KW - liquid chromatography
KW - penicillins
KW - fishes
KW - ictalurus
KW - salmon
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - Salmonidae
KW - Salmoniformes
KW - amoxycillin
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Robotic automated analysis of foods for aflatoxin.
AU - Carman, A. S., Jr.
AU - Kuan, S. S.
AU - Ware, G. M.
AU - Umrigar, P. P.
AU - Miller, K. V.
AU - Guerrero, H. G.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 2
SP - 456
EP - 464
SN - 1060-3271
AD - Carman, A. S., Jr.: U.S. Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122-3896, USA.
N1 - Accession Number: 19961201397. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Mycology; Dairy Science; Animal Nutrition; Human Nutrition; Postharvest Research; Maize
N2 - Immunoaffinity column-based sample preparation procedures for determination of aflatoxins B1, B2, G1 and G2 in several food matrices and aflatoxin M1 in milk were automated using flexible automation or robotics. Components used to assemble the system were purchased commercially or developed and built in-house. A liquid-level sensor developed in-house to assist elution of the immunoaffinity column is described. After immunoaffinity column cleanup, aflatoxins were separated by reversed-phase liquid chromatography and determined by fluorescence without derivatization. Mean recoveries of aflatoxins B1, B2 and G1 added to maize and groundnuts at 9-36 ng/g total aflatoxins were >85%. Mean recoveries of aflatoxin G2 were 50%. Mean recoveries of aflatoxin M1 added to milk at 0.12-0.50 ng/ml were 78%. The reproducibility of the automated system was demonstrated by the fact that the coefficient of variation of replicate assays was >10%.
KW - aflatoxins
KW - analytical methods
KW - automation
KW - chromatography
KW - contamination
KW - determination
KW - estimation
KW - feeds
KW - foods
KW - groundnuts
KW - liquid chromatography
KW - maize
KW - milk
KW - mycotoxins
KW - Arachis hypogaea
KW - Zea mays
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - aflatoxin M1
KW - analytical techniques
KW - corn
KW - feeding stuffs
KW - fungal toxins
KW - peanuts
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Milk and Dairy Produce (QQ010)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of tilmicosin in bovine milk by liquid chromatography with ultraviolet detection.
AU - Ngoh, M. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 3
SP - 652
EP - 655
SN - 1060-3271
AD - Ngoh, M. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Science, Building 328-A, BARC-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19960403052. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - In this method, samples are defatted by centrifugation at -4°C and 3000 rpm for 320 min. The lower skim layer is cleaned on a C18 solid-phase extraction cartridge. The extract is concentrated and analysed using a reversed-phase phenyl column with UV detection at 280 nm. The method was validated with control milk fortified at 50, 100 and 200 ng/ml. Average recoveries (and intra-laboratory coefficients of variation) were 97% (9%), 98% (5%) and 101% (3%), respectively. The limit of quantification was approximately 20 ng/ml, and the limit of detection was approximately 13 ng/ml. The method was tested on milk from a cow injected subcutaneously with tilmicosin at 10 mg/kg body weight.
KW - antibiotic residues
KW - antibiotics
KW - centrifugation
KW - chromatography
KW - detection
KW - determination
KW - drug residues
KW - liquid chromatography
KW - milk
KW - skim milk
KW - ultraviolet radiation
KW - tilmicosin
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of lincomycin residue in salmon tissues by ion-pair reversed-phase liquid chromatography with electrochemical detection.
AU - Luo WenHong
AU - Hansen, E. B., Jr.
AU - Ang, C. Y. W.
AU - Thompson, H. C., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 4
SP - 839
EP - 843
SN - 1060-3271
AD - Luo WenHong: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Chemistry, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19962215931. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 859-18-7, 154-21-2. Subject Subsets: Veterinary Science; Veterinary Science
N2 - A method is described for detecting and quantitating lincomycin residue in salmon muscle and skin tissues by ion-pair reversed-phase liquid chromatography (LC) with electrochemical detection at +0.9 V. Lincomycin was extracted from tissues by homogenizing with 0.01M KH2PO4 buffer (pH 4.5) and centrifuging the mixture. Water-soluble proteins were precipitated by adding sodium tungstate and sulfuric acid and removed by centrifugation. The buffer extract was then passed through a C18 solid-phase extraction cartridge. Lincomycin was eluted with 50% acetonitrile in water, and the eluate containing lincomycin was extracted with ethyl acetate. After the solvent had evaporated, the residue was redissolved in mobile phase and analysed by LC. The method had a limit of detection of 7 ng/g lincomycin for salmon muscle and 12 ng/g for salmon skin. The limit of quantitation was 17 ng/g for salmon muscle and 24 ng/g for salmon skin. Average recoveries of lincomycin spiked at 50, 100, and 200 ng/g were ≥85% for salmon muscle and ≥80% for salmon skin.
KW - antibiotics
KW - assays
KW - detection
KW - determination
KW - drug residues
KW - lincomycin
KW - liquid chromatography
KW - tissues
KW - Atlantic salmon
KW - fishes
KW - salmon
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - diadromous fishes
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - lincocin
KW - Salmo salar
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of ceftiofur in bovine milk by liquid chromatography.
AU - McNeilly, P. J.
AU - Reeves, V. B.
AU - Devau, E. J. I.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 4
SP - 844
EP - 847
SN - 1060-3271
AD - McNeilly, P. J.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Agricultural Research Center-East, Beltsville, MD 20705, USA.
N1 - Accession Number: 19960404871. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 80370-57-6. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A liquid chromatographic procedure is described for determination of ceftiofur (CEF) residues in milk. Milk samples were diluted with ammonium acetate solution and extracted on a C18 solid-phase extraction (SPE) column. After the analyte was eluted from the SPE column with methanol, extract volumes were reduced under nitrogen, diluted to 2.0 ml with acetate buffer, and filtered. CEF was determined after separation of milk components by reversed-phase chromatography with ultraviolet detection at 293 nm. Recoveries of CEF from bovine milk fortified at 25, 50, and 100 ppb were 86.1, 90.8 and 92.0%, respectively, with coefficients of variation (CV) of 6.4, 7.3 and 3.9%, respectively. Values of CEF obtained from analysis of milk containing 2 levels of residues (intramammary route) were 26.1 and 67.3 ppb with CV of 3.8 and 4.4%, respectively. The limits of detection and quantitation were 4 and 7 ppb, respectively.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - beta-lactam antibiotics
KW - ceftiofur
KW - cephalosporins
KW - chromatography
KW - cows
KW - determination
KW - drug residues
KW - liquid chromatography
KW - milk
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a rapid and automated enzyme-linked fluorescent immunoassay for detecting Escherichia coli serogroup O157 in cheese.
AU - Cohen, A. E.
AU - Kerdahi, K. F.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 4
SP - 858
EP - 860
SN - 1060-3271
AD - Cohen, A. E.: U.S. Food and Drug Administration, Northeast Regional Laboratory, 850 Third Avenue, Brooklyn, NY 11232, USA.
N1 - Accession Number: 19960404873. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The Vitek Immunodiagnostic Assay System (VIDAS), a rapid and fully automated test, was evaluated for detecting E. coli O157:H7 in soft, semi-soft and hard cheeses. 65 cheese samples were artificially contaminated at low (2-4 cfu/25 g) and high (7-10 cfu/25 g) levels with 1 of 2 strains of enterohaemorrhagic E. coli O157:H7. Contamination at high levels was detected in all cheeses by VIDAS, whereas in 5 cheeses (7.7%) inoculated at low levels, contamination was not detected. In 15 additional cheeses inoculated with cold-stressed cells, both VIDAS and the Bacteriological Analytical Manual cultural assay detected all high and low levels of contamination. No false positives or interference from product background fluorescence was encountered in any of the cheeses tested by VIDAS.
KW - analytical methods
KW - cheeses
KW - detection
KW - immunoassay
KW - Soft cheese
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and survey of deoxynivalenol in white flour, whole wheat flour, and bran.
AU - Trucksess, M. W.
AU - Ready, D. E.
AU - Pender, M. K.
AU - Ligmond, C. A.
AU - Wood, G. E.
AU - Page, S. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 4
SP - 883
EP - 887
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 19971200026. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 51481-10-8. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition; Human Nutrition
N2 - A liquid chromatographic (LC) method for determining deoxynivalenol [vomitoxin] (DON) in white flour, whole wheat flour and bran was developed. A 25 g test portion was extracted with acetonitrile-water (84+16) and the extract was filtered and applied to a column containing a combination of charcoal, Celite and other adsorbents. The eluate was then chromatographed on a silica-based, reversed-phase LC column by using a gradient of water and methanol. DON was measured at 220 nm. Mean recoveries of DON from white flour, whole wheat flour and bran spiked at 1 µg/g were 88, 86 and 85%, respectively. The limit of determination of the method was <0.5 µg/g. A total of 562 wheat-based products from the 1993 crop year were collected by 21 U.S. Food and Drug Administration District Offices and analysed by this method in Kansas City, Seattle and New Orleans District Laboratories. The numbers of samples with DON contamination ≥1 µg/g from 163 bran, 272 white flour, 90 whole wheat flour and 37 miscellaneous test samples were 20, 28, 14 and 2, respectively. Approx. 52, 50, 40 and 27% of the same test samples were contaminated with DON at levels >0.1 µg/g.
KW - analytical methods
KW - bran
KW - cereal flours
KW - contamination
KW - estimation
KW - liquid chromatography
KW - mycotoxins
KW - vomitoxin
KW - wheat bran
KW - wheat flour
KW - Kansas
KW - Louisiana
KW - USA
KW - Washington
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - Delta States of USA
KW - Southern States of USA
KW - Gulf States of USA
KW - West South Central States of USA
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - analytical techniques
KW - deoxynivalenol
KW - fungal toxins
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971200026&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of solid-phase extraction disks for analysis of moderately polar and nonpolar pesticides in high-moisture foods.
AU - Casanova, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 4
SP - 936
EP - 940
SN - 1060-3271
AD - Casanova, J. A.: U.S. Food and Drug Administration, 60 8th St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19961411274. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition; Agricultural Entomology; Postharvest Research
N2 - This study investigated the use of solid-phase extraction (SPE) disks in analysis of high-moisture (<2% fat) foods for organophosphorus and organochlorinated pesticides with low (<25 mg/ml) water solubilities. 5 representative foods were each spiked with 1 of 18 pesticides at 2 levels. Gas chromatography with flame photometric and electrolytic conductivity detection was used to quantitate organophosphates and organochlorinated pesticides, respectively. Essentially complete recoveries (≥80%) suggest that use of SPE disks can complement traditional liquid-liquid extraction procedures.
KW - agricultural entomology
KW - determination
KW - estimation
KW - foods
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - residues
KW - techniques
KW - organic chlorine pesticides
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of phenylbutazone residues in bovine milk by liquid chromatography with UV detection.
AU - Veau, E. J. I. de
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1050
EP - 1053
SN - 1060-3271
AD - Veau, E. J. I. de: U.S. Food and Drug Administration, Center for Veterinary Medicine, BARC-East, Building 328A, Beltsville, MD 20705, USA.
N1 - Accession Number: 19960404748. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 64-17-5, 60-29-7, 110-54-3, 7647-01-0, 50-33-9. Subject Subsets: Human Nutrition; Dairy Science
N2 - A published liquid chromatographic (LC) method was modified for quantitation of phenylbutazone (PBZ) residues in the range of 25-300 ng/ml in bovine milk. Milk samples (1 ml) were diluted with absolute ethanol and 25% NH4OH. Diethyl ether and petroleum ether were added sequentially to the milk extract and the mixture was agitated on a Vortex mixer to partition out milk fat. The organic phase was removed and discarded. Tetrahydrofuran-hexane (1 + 4) was added to the aqueous phase and the extract was acidified with 3M HCl. The samples were mixed on a Vortex mixer for 30 min, and centrifuged. The organic layer, containing PBZ, was transferred to a clean test tube. The organic solvents were evaporated to dryness under a stream of N2 at room temperature. The resulting extract was dissolved in 1 ml mobile phase and filtered before injection. The chromatographic system was a C18 reversed-phase column connected to a UV detector set at 264 nm. Recoveries of PBZ from bovine raw milk fortified at 25-300 ng/ml ranged from 79 to 84%; relative s.d. (RSDs) ranged from 6 to 7%. The RSDs for incurred PBZ quantitated from 34 to 229 ng/ml ranged from 1 to 4%.
KW - analytical methods
KW - chromatography
KW - detection
KW - determination
KW - drug residues
KW - drugs
KW - ethanol
KW - ethyl ether
KW - hexane
KW - hydrochloric acid
KW - liquid chromatography
KW - milk
KW - milk fat
KW - phenylbutazone
KW - analytical techniques
KW - butterfat
KW - diethyl ether
KW - ethyl alcohol
KW - medicines
KW - pharmaceuticals
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of pirlimycin residue in bovine milk and liver by liquid chromatography/thermospray mass spectrometry: interlaboratory study.
AU - Heller, D. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1054
EP - 1061
SN - 1060-3271
AD - Heller, D. N.: U.S. Food and Drug Administration, Center for Veterinary Medicine, BARC-East, Building 328A, Beltsville, MD 20705, USA.
N1 - Accession Number: 19960404793. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - Three laboratories in the USA participated in trials of methods to determine and confirm pirlimycin residue in bovine milk and liver. The methods used liquid chromatography/thermospray mass spectrometry (LC/MS) with an internal standard to measure residue concentration. The internal standard was isopirlimycin, a stereoisomer of pirlimycin, which was resolved chromatographically. Determinative procedures were validated by replicate analyses of negative control, fortified control and residue-incurred milk. For the milk method, average corrected recoveries (and coefficients of variation, CVs) were 83-113% (CV, 7.5-15.4%) at 0.2 p.p.m., 91-98% (CV, 3.4-18.5%) at 0.4 p.p.m and 89-102% (CV, 8.8-22.9%) at 0.8 p.p.m. For the liver method, average corrected recoveries were 94-103% (CV, 2.2-7.1%) at 0.25 p.p.m, 87-94% (CV, 4.8-10.3%) at 0.5 p.p.m and 96-101% (CV, 5.5-6.9%) at 1.0 p.p.m. There were no interferences in control samples of either matrix. Pirlimycin was confirmed by matching the retention time and relative abundances of 4 ions from sample extracts to corresponding values obtained for pirlimycin standard. Pirlimycin was confirmed in all residue-incurred samples and all samples fortified at regulatory tolerances (0.4 p.p.m in milk and 0.5 p.p.m in liver) by 2 of the 3 laboratories and in most samples by the 3rd laboratory.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - chromatography
KW - determination
KW - drug residues
KW - drugs
KW - liquid chromatography
KW - liver
KW - mass spectrometry
KW - milk
KW - residues
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - pirlimycin
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of trichothecene mycotoxins in contaminated grains by gas chromatography/matrix isolation/Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry.
AU - Mossoba, M. M.
AU - Adams, S.
AU - Roach, J. A. G.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1116
EP - 1123
SN - 1060-3271
AD - Mossoba, M. M.: U.S. Food and Drug Administration, Division of General Scientific Support, Washington, DC 20204, USA.
N1 - Accession Number: 19961202365. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 23255-69-8, 23282-20-4, 51481-10-8. Subject Subsets: Horticultural Science; Medical & Veterinary Mycology; Wheat, Barley & Triticale Abstracts; Animal Nutrition; Human Nutrition; Postharvest Research
N2 - Gas chromatography/matrix isolation/Fourier transform infrared (GC/MI/FTIR) spectroscopy and GC/MS were used to confirm the identities of trimethylsilyl (TMS) derivatives of trichothecenes in naturally contaminated grains grown in Maryland, USA, in 1994. Infrared spectral bands observed in the fingerprint region were unique for 10 trichothecene standards. Characteristic absorption bands were observed for the ester (near 1750/cm) and ketone (near 1700/cm) carbonyl stretching vibrations, the acetate CH3 symmetric bend (1370/cm), the epoxide ring (1262/cm), the trimethylsilyl CH3 in-plane deformation (1253/cm), the ester (O)C-O asymmetric stretching vibration (near 1244/cm) and several other bands including intense features due to the TMS function. Infrared bands observed under cryogenic matrix isolation conditions were compared with those found at room temp. in a potassium bromide matrix for 5 of these standards. Identities of deoxynivalenol [vomitoxin] (DON) from barley and mixed feed, nivalenol from wheat and barley, and DON and fusarenon-X from sweetcorn were confirmed by comparison of their infrared spectral bands with those of standards. The identity of DON in the same test samples of sweetcorn was confirmed further by GC/MS. GC/MS was also used to quantitate the levels of DON (67-455 p.p.m.) in sweetcorn test samples.
KW - analytical methods
KW - barley
KW - cereal grains
KW - cereals
KW - contamination
KW - detection
KW - feeds
KW - foods
KW - fusarenon-X
KW - gas chromatography
KW - grain
KW - infrared spectroscopy
KW - maize
KW - mass spectrometry
KW - mycotoxins
KW - nivalenol
KW - sweetcorn
KW - trichothecenes
KW - vomitoxin
KW - wheat
KW - Maryland
KW - USA
KW - Hordeum
KW - Hordeum vulgare
KW - Triticum
KW - Zea mays
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Hordeum
KW - Zea
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - corn
KW - deoxynivalenol
KW - feeding stuffs
KW - fungal toxins
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of selenium in infant formula and enteral formula by dry ash graphite furnace atomic absorption spectrometry with deuterium background correction.
AU - Cook, K. K.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1162
EP - 1166
SN - 1060-3271
AD - Cook, K. K.: U.S. Food and Drug Administration, Division of Science and Applied Technology, HFS-175, Office of Food Labeling, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971403189. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7782-39-0, 7782-42-5, 7782-49-2. Subject Subsets: Human Nutrition; Dairy Science
N2 - The method described circumvents the use of perchloric acid, 2,3-diaminonapthalene (DAN) and hydride generation without the use of Zeeman background correction. 12 commercial infant and enteral formulas and corresponding spiked products (30-500 ng) were analysed in triplicate for Se to evaluate this method. All test portions were digested on a hot plate after addition of magnesium nitrate-nitric acid. Following heating, digests were evaporated to dryness and placed in a 500°C muffle furnace for 30 min to complete ashing. All Se was converted to Se+4 by dissolving the ash in HCl (5 + 1) and holding the solution for 20 min in a 60°C water bath. Se+4 was subsequently reduced to Se0 with ascorbic acid and collected on a membrane filter. The membrane filters were digested in a small volume of nitric acid in a microwave oven. Following digestion, contents of the vessels were diluted and analysed for Se by graphite furnace atomic absorption spectrometry. Selenium standards in starch or in unfortified formula containing trace levels of Se were carried through the entire process. The recovery range for Se was 85-127%, and analysed reference materials fell within their certified range for Se. This method is as sensitive (detection limit 0.44 ng/g) as methods reported in the literature and may be applicable to other foods.
KW - absorption
KW - analytical methods
KW - ash
KW - determination
KW - deuterium
KW - enteral feeding
KW - graphite
KW - infant formulae
KW - milk products
KW - selenium
KW - solutions
KW - spectrometry
KW - trace elements
KW - analytical techniques
KW - atomic absorption spectrometry
KW - dairy products
KW - infant formula
KW - infant formulas
KW - microelements
KW - Milk and Dairy Produce (QQ010)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of organochlorine pesticide and polychlorinated biphenyl residues in fatty fish by tandem solid-phase extraction cleanup.
AU - Schenck, F. J.
AU - Calderon, L.
AU - Podhorniak, L. V.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1209
EP - 1214
SN - 1060-3271
AD - Schenck, F. J.: US Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 19970504451. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology
N2 - A rapid, multiresidue solid-phase extraction (SPE) technique for determination of organochlorine pesticide and polychlorinated biphenyl (PCB) residues in non-fatty fish was modified for use with fatty fish. In the modified procedures, samples were extracted with acetonitrile, and the extract was cleaned up with both C18 and Florisil SPE columns. Residues were determined by gas chromatography with electron capture detection. The original method was modified for use with fatty fish by reducing the amount of tissue extracted and by using an improved Florisil SPE cleanup. Recovery data are presented for 24 fortified organochlorine pesticide residues (0.12 ppm) and 3 fortified PCB residues (0.80 ppm) (collected as part of the FDA residue sampling plan for fish in the USA) from flounder [Platichthys flesus], bluefish [Pomatomus saltatrix], and shad [Alosa sapidissima] samples, which contained 0.8, 5.4, and 22.6% fat, respectively. For the 3 types of fish, recoveries of 23 of 24 fortified organochlorine pesticide residues ranged from 55-129%, and recoveries of 3 fortified PCB residues ranged from 55-104%. There were no significant differences in recovery based on fish species and/or fat content for the majority of residues studied. This SPE method and the official AOAC method yielded comparable results for fish containing incurred organochlorine residues.
KW - analytical methods
KW - extraction
KW - fats
KW - fish
KW - gas chromatography
KW - insecticide residues
KW - marine environment
KW - marine fishes
KW - organochlorine insecticides
KW - pesticide residues
KW - polychlorinated biphenyls
KW - residues
KW - techniques
KW - toxic substances
KW - Atlantic ocean
KW - USA
KW - Alosa sapidissima
KW - fishes
KW - flounder
KW - Platichthys flesus
KW - Pomatomus
KW - Alosa
KW - Clupeidae
KW - Clupeiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Pleuronectiformes
KW - Platichthys
KW - Pleuronectidae
KW - Pomatomidae
KW - Perciformes
KW - Pomatomus
KW - oceans
KW - marine areas
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - PCBs
KW - poisons
KW - Pomatomus saltatrix
KW - sea fishes
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening of nonfatty fish for organochlorine pesticide residues by solid-phase extraction cleanup: interlaboratory study.
AU - Schenck, F. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1215
EP - 1219
SN - 1060-3271
AD - Schenck, F. J.: US Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 19970504452. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 608-73-1, 76-44-8, 58-89-9, 72-55-9, 72-20-8. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology
N2 - A total of 6 USA Food and Drug Administration laboratories participated in an interlaboratory trial of a solid-phase extraction cleanup methods for the determination of pesticides in non-fatty seafood products. The participants analysed control and fortified (about 0.050 ppm lindane, heptachlor epoxide, p,p′-DDE, and endrin) croaker [Micropogonias undulatus] and flounder [Platichthys flesus] samples and a sea trout [Salmo trutta] sample containing incurred p,p′-DDE residues. Mean recoveries of the fortified residues from the fish ranged from 89.1 to 107.8%. The within-laboratory coefficients of variation (CVs) ranged from 4.2 to 8.5%, and the among-laboratory CVs ranged from 10.9 to 26.5%. The 6 laboratories reported a mean value of 0.040 ppm p,p′-DDE in a fish sample which contained incurred residues. The same value (0.040 ppm) was obtained by using official methodology. The within-laboratory CVs ranged from 3.5 to 18.3%, and the among-laboratory CV was 17.3%.
KW - analytical methods
KW - cyclodiene insecticides
KW - DDE
KW - endrin
KW - fish
KW - HCH
KW - heptachlor
KW - insecticide residues
KW - lindane
KW - marine environment
KW - marine fishes
KW - organochlorine insecticides
KW - pesticide residues
KW - residues
KW - techniques
KW - Atlantic ocean
KW - USA
KW - brown trout
KW - fishes
KW - flounder
KW - Platichthys flesus
KW - Salmo trutta
KW - Sciaenidae
KW - trout
KW - Salmo trutta
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Pleuronectiformes
KW - Platichthys
KW - Pleuronectidae
KW - Perciformes
KW - oceans
KW - marine areas
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - benzene hexachloride
KW - BHC
KW - Micropogonias
KW - Micropogonias undulatus
KW - p,p'-dichlorodiphenyldichloroethylene
KW - sea fishes
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of identities of flumequine and nalidixic, oxolinic, and piromidic acids in salmon and shrimp.
AU - Pfenning, A. P.
AU - Munns, R. K.
AU - Turnipseed, S. B.
AU - Roybal, J. E.
AU - Holland, D. C.
AU - Long, A. R.
AU - Plakas, S. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 5
SP - 1227
EP - 1235
SN - 1060-3271
AD - Pfenning, A. P.: U.S. Food and Drug Administration, Animal Drugs Research Center and General Chemistry Section, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19972218346. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 14698-29-4. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science
N2 - A previously published liquid chromatographic (LC) method for determining residues of flumequine (FLU) and nalidixic (NAL), oxolinic (OXO), and piromidic (PIR) acids in catfish tissue was applied to salmon and shrimp muscle. Identities of all 4 residues in salmon and shrimp were confirmed by gas chromatography/mass spectrometry (GC/MS). The tissue is homogenized with acetone, the acetone extract is defatted with hexane, and the quinolones are extracted into chloroform. The extract is further purified by first partitioning into base and then back-extracting from a solution acidified to pH 6.0. Analytes are determined by LC with simultaneous UV and fluorescence detection. Muscle tissue was fortified with each quinolone at 5, 10, 20, 40, and 80 ng/g. Average recoveries and relative standard deviations (RSDs) for salmon, which represent an average of the 5 levels for each analyte, ranged from 75.9 to 90.8% and from 2.25 to 6.40%, respectively. Average recoveries and RSDs for shrimp ranged from 81.3 to 91.2% and from 7.34 to 10.7%, respectively. Identities of OXO, FLU, NAL, and PIR were confirmed in extracts of salmon and shrimp tissue fortified at 10 ng/g by determination of decarboxylated quinolones by GC/MS. Four diagnostic ions were monitored for OXO, FLU, and PIR, and 5 ions were monitored for NAL. All ion relative abundances were within 10% of those calculated for standard decarboxylated quinolones. Optimum conditions for decarboxylation and GC/MS confirmation are given.
KW - assays
KW - determination
KW - drug residues
KW - oxolinic acid
KW - quinolones
KW - shrimps
KW - Atlantic salmon
KW - Decapoda
KW - salmon
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - diadromous fishes
KW - flumequine
KW - Salmo salar
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative effectiveness of selenite cystine broth, tetrathionate broth, and rappaport-vassiliadis medium for recovery of Salmonella spp. from raw flesh, highly contaminated foods, and poultry feed: collaborative study.
AU - June, G. A.
AU - Sherrod, P. S.
AU - Hammack, T. S.
AU - Amaguaña, R. M.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 6
SP - 1307
EP - 1323
SN - 1060-3271
AD - June, G. A.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19971402547. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Poultry
N2 - A collaborative study was performed in 18 laboratories to validate use of Rappaport-Vassiliadis (RV) medium in the standard culture method for recovery of Salmonella spp. from raw, highly contaminated foods and poultry feed. RV medium made from its individual ingredients and incubated at 42°C was compared with selenite cystine (SC) broth incubated at 35°C and tetrathionate (TT) broth incubated at 35 and 43°C for effectiveness in recovery of Salmonella spp. 4 artificially contaminated foods (oysters, frog legs, mushrooms and shrimp) and poultry feed and 1 naturally contaminated food (chicken) were analysed. The artificially contaminated foods were inoculated with single serovars of Salmonella at target levels of 0.04 CFU/g for the low level and 0.4 CFU/g for the high level. For analysis of 1125 test portions, RV medium (42°C) recovered Salmonella from 409 test portions; TT (43°C), from 368 test portions; TT (35°C), from 310 test portions; and SC (35°C), from 334 test portions. Overall, RV medium was comparable with or better than other selective enrichments for recovery of Salmonella from the foods in this study, except mushrooms. From mushrooms, SC broth (35°C) recovered more positive test portions than did RV medium (42°C) and TT broth (43°C). The method for detection of Salmonella in raw, highly contaminated foods and poultry feed using RV medium has been adopted by AOAC INTERNATIONAL. AOAC Official Method 967.25, Salmonella in Foods, Preparation of Culture Media and Reagents, has been revised to include RV medium, and the applicability of AOAC Official Method 967.26, Salmonella in Foods, Detection, has been restricted to processed foods.
KW - chicken meat
KW - culture media
KW - edible fungi
KW - feeds
KW - food contamination
KW - foods
KW - isolation
KW - mushrooms
KW - oysters
KW - poultry
KW - shrimps
KW - fowls
KW - frogs
KW - fungi
KW - Salmonella
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Anura
KW - Amphibia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - chickens
KW - domesticated birds
KW - feeding stuffs
KW - food contaminants
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Feed Contamination, Residues and Toxicology (RR200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of three methods for determining aflatoxins in melon seeds.
AU - DiProssimo, V. P.
AU - Malek, E. G.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 6
SP - 1330
EP - 1335
SN - 1060-3271
AD - DiProssimo, V. P.: U.S. Food and Drug Administration, Northeast Regional Laboratory, Brooklyn, NY 11232, USA.
N1 - Accession Number: 19971200300. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition; Horticultural Science; Medical & Veterinary Mycology; Postharvest Research
N2 - The suitability of 3 methods for determining aflatoxins in melon seeds was examined. The Contaminants Branch (CB) method and the Best Foods (BF) method were both official methods for determining aflatoxins in peanuts [groundnuts] and groundnut products while the 3rd method used was the modified CB method-Rapid Modification of the Cottonseed (CB-RCS-Mod) method which was derived by combining steps from the CB method and the Rapid Modification of the Cottonseed method. The CB method was superior to the other 2 methods for quantitation of aflatoxins. It gave better recoveries and cleaner extracts that exhibited less fluorescent interference for thin-layer chromatography (TLC) than the BF method. Also, its solvent efficiency was better than that of the CB-RCS-Mod method. With the CB method, recoveries from spiked samples were 85.0% for aflatoxin B1 and 90.0% for aflatoxin B2. Recoveries of G aflatoxins were more variable, averaging 90.0% for aflatoxin G1 and 72.5% for aflatoxin G2. Total aflatoxin recovery was 86.5% for the CB method. At a low aflatoxin contamination level (8 µg/kg B1), aflatoxin B1 was detectable by the CB method but not by the BF method. Detection of aflatoxins in BF method sample extracts by TLC was not improved by the use of chloroform-acetone-water (88+12+1), benzene-ethanol-water, or ether-methanol-water (96+3+1) in place of the standard chloroform-acetone (88+12) developer. Use of ether-methanol-water (96+3+1) for detecting aflatoxins by TLC in the CB method extracts increased interference compared with the standard chloroform-acetone (88+12) developer.
KW - aflatoxins
KW - analytical methods
KW - contamination
KW - estimation
KW - melons
KW - methodology
KW - mycotoxins
KW - seeds
KW - thin layer chromatography
KW - watermelons
KW - Citrullus lanatus
KW - Cucumis melo
KW - Citrullus
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Cucumis
KW - analytical techniques
KW - fungal toxins
KW - melon seeds
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Florisil solid-phase extraction cartridges for cleanup of organochlorine pesticide residues in foods.
AU - Schenck, F. J.
AU - Calderon, L.
AU - Saudarg, D. E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1996///
VL - 79
IS - 6
SP - 1454
EP - 1458
SN - 1060-3271
AD - Schenck, F. J.: U.S. Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 19971402546. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology; Dairy Science
N2 - Florisil solid-phase extraction (SPE) cartridges were evaluated for cleanup of organochlorine pesticide residues in milk by matrix solid-phase dispersion extraction and in crab meat by tandem SPE cartridge cleanup. Elution patterns and recoveries were determined for 24 organochlorine pesticides. A range of elution solvents was evaluated. A 2% ethyl ether-petroleum ether eluant optimized overall recoveries while minimizing interferences from coextractants.
KW - analytical methods
KW - crab meat
KW - determination
KW - extraction
KW - foods
KW - gas chromatography
KW - milk
KW - organochlorine insecticides
KW - organochlorine pesticides
KW - pesticide residues
KW - pesticides
KW - analytical techniques
KW - organic chlorine pesticides
KW - Milk and Dairy Produce (QQ010)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Conservation of low-copy gene loci in Old World leishmanias identifies mechanisms of parasite evolution and diagnostic markers.
AU - Pogue, G. P.
AU - Manju Joshi
AU - Lee, N. S.
AU - Dwyer, D. M.
AU - Kenney, R. T.
AU - Gam, A. A.
AU - Nakhasi, H. L.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1996///
VL - 81
IS - 1
SP - 27
EP - 40
SN - 0166-6851
AD - Pogue, G. P.: Laboratory of Molecular Pharmacology, Division of Hematologic Products, OTRR, CBER, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19960805662. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Protozoology
N2 - Divergence in single and low-copy genes was evaluated in terms of locus organization, chromosomal localization and gene expression in Leishmania infantum, L. major, L. tropica and 3 widely divergent geographic isolates of L. donovani. 17 genes of low to moderate copy number (1-4 copies/haploid genome) were analysed to identify restriction fragment length polymorphisms (RFLPs) providing heritable markers distinguishing Old World (OW) leishmanias. These RFLP markers were conserved in parasite isolates from primary infections, demonstrating their utility as diagnostic tools. The species designations established by RFLP analysis of field isolates was confirmed by the use of MAbs. All 17 genes were present in each OW leishmania analysed except LSIP (A45), which was absent from L. infantum. The 17 genes were distributed among 9 distinct chromosomes. However, in spite of variations in chromosome karyotypes among the various OW leishmanias, individual gene probes localized to a similar sized chromosome from each isolate. These observations coupled with a molecular tree derived from RFLP data suggest that the OW leishmanias comprise a monophyletic lineage, with species associated with cutaneous disease exhibiting the greatest level of divergence. The findings support previous observations that species causing cutaneous and visceral disease have diverged primarily by nucleotide substitutions. Such nucleotide divergence may not only lead to changes in protein function and antigenicity, but may also alter gene regulation programmes as exemplified by the finding that the LdI-9-5 and LdE-6-1 genes were expressed only in visceralizing leishmanias. [Nucleotide sequence data submitted to GenBank, accession number U49191].
KW - conservation
KW - cutaneous leishmaniasis
KW - evolution
KW - genes
KW - human diseases
KW - loci
KW - markers
KW - molecular genetics
KW - molecular taxonomy
KW - parasites
KW - phylogeny
KW - restriction fragment length polymorphism
KW - visceral leishmaniasis
KW - Leishmania
KW - Leishmania donovani
KW - Leishmania infantum
KW - Leishmania major
KW - Leishmania tropica
KW - protozoa
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Leishmania
KW - biochemical genetics
KW - RFLP
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterization of Leishmania donovani calreticulin gene and its conservation of RNA binding activity.
AU - Manju Joshi
AU - Pogue, G. P.
AU - Duncan, R. C.
AU - Lee, N. S.
AU - Singh, N. K.
AU - Atreya, C. D.
AU - Dwyer, D. M.
AU - Nakhasi, H. L.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1996///
VL - 81
IS - 1
SP - 53
EP - 64
SN - 0166-6851
AD - Manju Joshi: Laboratory of Molecular Pharmacology, Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892-0425, USA.
N1 - Accession Number: 19960805665. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology
N2 - The calreticulin gene was isolated and characterized from Leishmania donovani. Amino acid sequence homology between human and Leishmania calreticulin (L. d. cal) was limited, but like the human homologue, L. d. cal bound Ca++, was phosphorylated in vitro and bound certain RNA sequences in a phosphorylation-dependent manner. Unlike human calreticulin, L. d. cal was glycosylated and its binding to endogenous Leishmania RNA was phosphorylation-independent. The binding of L. d. cal to Leishmania RNA suggests that the RNA binding activity of calreticulin has remained evolutionarily conserved. [Nucleotide sequence data submitted to GenBank, accession number U49191].
KW - activity
KW - amino acid sequences
KW - binding
KW - calcium binding proteins
KW - conservation
KW - evolution
KW - genes
KW - molecular genetics
KW - parasites
KW - phosphorylation
KW - rna
KW - Leishmania donovani
KW - protozoa
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - calreticulin
KW - protein sequences
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ehrlichia-like 16S rDNA sequence from wild white-tailed deer (Odocoileus virginianus).
AU - Dawson, J. E.
AU - Warner, C. K.
AU - Baker, V.
AU - Ewing, S. A.
AU - Stallknecht, D. E.
AU - Davidson, W. R.
AU - Kocan, A. A.
AU - Lockhart, J. M.
AU - Olson, J. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1996///
VL - 82
IS - 1
SP - 52
EP - 58
SN - 0022-3395
AD - Dawson, J. E.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19960503707. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - The reservoir hosts of E. chaffeensis, aetiological agent of human ehrlichiosis, are unknown. Initially, white-tailed deer (WTD) were serologically implicated as possible reservoirs of E. chaffeensis. Subsequent studies showed that WTD were susceptible to infection with E. chaffeensis and that deer-to-deer transmission by a tick vector, Amblyomma americanum, is possible under experimental conditions. To determine if wild WTD were infected with E. chaffeensis, whole blood was collected from 10 deer from Oklahoma and Georgia, USA. All 10 deer had antibodies reactive to E. chaffeensis. Whereas E. chaffeensis was not isolated, restriction enzyme mapping and sequencing of the 16S rDNA gene revealed that a unique Ehrlichia-like agent was present. All 10 deer appeared to be infected with the same agent. It was suspected that A. americanum is the vector of this new agent based upon the previously published temporal association between the appearance of E. chaffeensis seropositive WTD and A. americanum. However, the taxonomic and antigenic relationships, geographical distribution, epidemiology and zoonotic potential of this agent are yet to be determined.
KW - disease vectors
KW - ehrlichioses
KW - epidemiology
KW - reservoir hosts
KW - ribosomal DNA
KW - wild animals
KW - zoonoses
KW - Georgia
KW - Oklahoma
KW - USA
KW - Acari
KW - Amblyomma americanum
KW - Arachnida
KW - Ehrlichia
KW - Ehrlichia chaffeensis
KW - Odocoileus
KW - Odocoileus virginianus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Amblyomma
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ehrlichia
KW - Cervidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Odocoileus
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - Great Plains States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - animal reservoirs
KW - bacterium
KW - Ehrlichia infections
KW - ehrlichiosis
KW - lone star tick
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunopurification and measurement of IgE in serum samples from bancroftian filariasis patients.
AU - Marley, S. E.
AU - Lammie, P. J.
AU - Eberhard, M. L.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1996///
VL - 82
IS - 1
SP - 178
EP - 181
SN - 0022-3395
AD - Marley, S. E.: Division of Parasitic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341-3724, USA.
N1 - Accession Number: 19960803426. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 37341-29-0, 308067-58-5, 308067-57-4. Subject Subsets: Helminthology
N2 - To determine if IgG4 or other isotypes inhibit the detection of parasite-specific IgE, total IgE was affinity purified prior to filaria-specific IgE enzyme-linked immunosorbent assay. Briefly,anti-human IgE mouse monoclonal antibody 6H10 was coupled to Affigel, and 50 µl of patient serum was incubated on microcolumns for 16 h. Total IgE was eluted with 25 mM triethylamine (pH 11.2) and levels of total and filaria-specific IgE and total IgG4 were assessed in the filtrates and eluates. Sera from 14 patients with W. bancrofti microfilaraemia (Mf+) and 17 amicrofilaraemic patients with chronic pathology (CP) in Haiti were assayed. Filtrates and eluates were devoid of IgE and IgG4, respectively. The average yield of total IgE in the eluates was 70% (SEM=6.5; range 21-100%) of that measured in the serum. Antifilarial IgE levels in column eluates were significantly higher in serum samples from CP patients than Mf+ patients. Antibody inhibition of IgE was assessed by comparing the levels of anti-filarial IgE detected in eluates and serum. Evidence for antibody-mediated inhibition of IgE detection was obtained with 1 of 2 samples from Indian tropical pulmonary eosinophilia patients, but only 2 of 14 and 4 of 17 Mf+ and CP patients, respectively.
KW - ELISA
KW - filariasis
KW - filariids
KW - helminths
KW - human diseases
KW - ige
KW - IgG
KW - immune evasion
KW - immune response
KW - immunodiagnosis
KW - immunoglobulins
KW - measurement
KW - parasites
KW - patients
KW - samples
KW - serum
KW - Haiti
KW - man
KW - Wuchereria bancrofti
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Wuchereria
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Least Developed Countries
KW - Developing Countries
KW - enzyme linked immunosorbent assay
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - metrology
KW - nematodes
KW - parasitic worms
KW - reagin
KW - reaginic antibodies
KW - Secernentea
KW - serological diagnosis
KW - Spirurida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Observations on the biological nature of Plasmodium vivax sporozoites.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Galland, G. G.
AU - Richardson, B. R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1996///
VL - 82
IS - 2
SP - 216
EP - 219
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19960803949. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - The relapsing malaria parasites are characterized by the production of sporozoites with varying potential for exoerythrocytic development. Some sporozoites develop soon after introduction to produce mature schizonts and merozoites that initiate the erythrocytic stage infection. Relapsing hypnozoite forms are characteristic of some strains of Plasmodium vivax and are more apt to develop late than early with many time intervals in between. Studies in Saimiri monkeys suggest another type of sporozoite-induced infection. With the Salvador I strain of P. vivax, early developing exoerythrocytic schizonts apparently release parasites with different levels of virulence for these monkeys, ranging from those producing high-level parasitaemia to a more abundant avirulent form. The induction of low-density avirulent infections requires the development of more sensitive detection methods for the evaluation of sporozoite vaccines.
KW - developmental stages
KW - immunization
KW - laboratory animals
KW - parasites
KW - sporozoites
KW - virulence
KW - plasmodium vivax
KW - protozoa
KW - Saimiri
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - growth phase
KW - immune sensitization
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sporozoite transmission of three strains of Plasmodium knowlesi to Aotus and Saimiri monkeys.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Richardson, B. B.
AU - Galland, G. G.
AU - Sullivan, J. J.
AU - Collins, W. E.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1996///
VL - 82
IS - 2
SP - 268
EP - 271
SN - 0022-3395
AD - Sullivan, J. S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19960803958. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Attempts were made to infect Aotus azarae boliviensis, hybrid Aotus and Saimiri boliviensis monkeys with sporozoites of 3 strains of Plasmodium knowlesi to determine the potential of these animals in a monkey/malaria model. Splenectomized Saimiri and Aotus monkeys were infected with the H strain of P. knowlesi via sporozoites from Anopheles dirus mosquitoes. Prepatent periods ranged from 5 to 16 days. Saimiri monkeys infected with the Philippine strain had prepatent periods ranging from 6 to 8 days. Saimiri monkeys infected with the Hackeri strain had prepatent periods ranging from 6 to 11 days. Exoerythrocytic (EE) stages of the Philippine strain were readily demonstrated; EE stages of the H strain were less abundant. Results indicate that the Philippine strain of P. knowlesi in Saimiri monkeys has a course of parasitaemia and EE stages similar to those previously seen in macaques and could serve as a reproducible model for biological and immunological studies.
KW - disease models
KW - disease transmission
KW - disease vectors
KW - experimental infections
KW - laboratory animals
KW - parasites
KW - sporozoites
KW - strains
KW - transmission
KW - Anopheles dirus
KW - Aotus
KW - Aotus azarae
KW - Culicidae
KW - Diptera
KW - monkeys
KW - Plasmodium knowlesi
KW - protozoa
KW - Saimiri
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adenovirus masquerading as Microsporidia.
AU - Visvesvara, G. S.
AU - Leitch, G. J.
AU - Wallace, S.
AU - Seaba, C.
AU - Erdman, D.
AU - Ewing, E. P., Jr.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1996///
VL - 82
IS - 2
SP - 316
EP - 319
SN - 0022-3395
AD - Visvesvara, G. S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
N1 - Accession Number: 19960804011. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Protozoology
N2 - Attempts to establish an in vitro culture system using mammalian cell cultures inoculated with duodenal aspirates, biopsy, or both, from 2 infected patients resulted in inadvertent coculture of an adenovirus and Enterocytozoon bieneusi. The adenovirus-infected cells deceptively appeared to contain spores of microsporidia based on light microscopic examination. Transmission electron microscopy revealed only a few microsporidia, but numerous cells infected with an adenovirus that was subsequently identified as adenovirus type 8. It is believed that adenovirus infections prevented the cultured cells from supporting the proliferation of E. bieneusi and ultimately destroyed the cell cultures.
KW - in vitro
KW - interactions
KW - parasites
KW - adenoviridae
KW - Enterocytozoon bieneusi
KW - microspora
KW - protozoa
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Enterocytozoon
KW - Enterocytozoonidae
KW - Microspora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasmodium falciparum: involvement of additional receptors in the cytoadherence of infected erythrocytes to microvascular endothelial cells.
AU - Xiao LiHua
AU - Yang ChunFu
AU - Dorovini-Zis, K.
AU - Tandon, N. N.
AU - Ades, E. W.
AU - Lal, A. A.
AU - Venkatachalam Udhayakumar
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1996///
VL - 84
IS - 1
SP - 42
EP - 55
SN - 0014-4894
AD - Xiao LiHua: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
N1 - Accession Number: 19970804721. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Protozoology
N2 - The roles of each of the 5 known ligands in the binding of Plasmodium falciparum-parasitized erythrocytes (PRBC) to endothelial cells were investigated. The results suggested that additional ligands are involved in the PRBC binding process.
KW - cytoadherence
KW - endothelium
KW - erythrocytes
KW - host parasite relationships
KW - ligands
KW - parasites
KW - receptors
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - blood red cells
KW - cell adhesion
KW - endothelial cells
KW - parasite host relationships
KW - red blood cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess.
AU - Ward, E. M.
AU - Sabbioni, G.
AU - DeBord, D. G.
AU - Teass, A. W.
AU - Brown, K. K.
AU - Talaska, G. G.
AU - Roberts, D. R.
AU - Ruder, A. M.
AU - Streicher, R. P.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 1996///
VL - 88
IS - 15
SP - 1046
EP - 1052
SN - 0027-8874
AD - Ward, E. M.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA.
N1 - Accession Number: 19962009305. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - An environmental and biological monitoring survey was conducted to evaluate current exposures to aniline and o-toluidine in the rubber chemicals department of a chemical manufacturing facility in Niagara Falls, NY, USA. A total of 73 workers, including 46 of 64 exposed workers who were employed in the rubber chemicals department and had the potential for exposure to aniline and o-toluidine and 27 of 52 unexposed workers employed in other departments where aniline and o-toluidine were not used or produced, had data available for both aniline and o-toluidine and haemoglobin (Hb) adducts; 28 of the workers in the former group also had personal air-sampling data. Personal air sample measurements showed that airborne concentrations of aniline and o-toluidine were well within the limits allowed in the workplace by the Occupational Safety and Health Administration (OSHA). Urinary aniline and o-toluidine levels, however, were substantially higher among exposed workers than among unexposed control subjects. The most striking differential was for postshift urinary o-toluidine levels, which averaged (±standard deviation) 2.8 μg/l (±1.4 μg/l) in unexposed subjects and 98.7 μg/l (±119.4 μg/l) in exposed subjects (P = 0.0001). Average aniline-Hb and o-toluidine-Hb adduct levels were also significantly higher (P = 0.0001) among exposed workers than among unexposed control subjects. Average levels of adducts to 4-ABP, a potential contaminant of process chemicals, were not significantly different (P = 0.48), although 3 exposed workers had 4-ABP levels above the range in unexposed workers. The adduct data suggest that, among current workers, o-toluidine exposure substantially exceeds aniline exposure and that 4-ABP exposure, if it occurs at all, is not widespread. These data support the conclusion that occupational exposure to o-toluidine is the most likely causal agent of the bladder cancer excess previously observed among workers in the rubber chemicals department of the plant under study, although exposures to aniline and 4-ABP cannot be ruled out.
KW - amines
KW - aromatic compounds
KW - bladder
KW - chemical workers
KW - exposure
KW - monitoring
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - toxicology
KW - workers
KW - New York
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aromatics
KW - cancer sites
KW - cancers
KW - occupational safety
KW - surveillance systems
KW - United States of America
KW - urinary bladder
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962009305&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The global resurgence of arboviral diseases.
AU - Gubler, D. J.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 1996///
VL - 90
IS - 5
SP - 449
EP - 451
SN - 0035-9203
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970501224. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases
N2 - The resurgence of arboviral diseases (e.g. dengue) that occurred in 1980-95 is briefly reviewed, and factors relating to their emergence as major public health problems (e.g. population growth, lack of effective mosquito control, increased mosquito densities and expanded geographical distribution, geographical spread of arboviruses and vectors, and genetic variation) are discussed.
KW - arboviruses
KW - dengue
KW - emerging infectious diseases
KW - epidemics
KW - human diseases
KW - infectious diseases
KW - mosquito-borne diseases
KW - resurgence
KW - reviews
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - arthropod-borne viruses
KW - communicable diseases
KW - emerging diseases
KW - emerging infections
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501224&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The challenge of regulating health claims and food fortification.
AU - Yetley, E. A.
AU - Rader, J. I.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996///
VL - 126
IS - 3
SP - 765S
EP - 772S
SN - 0022-3166
AD - Yetley, E. A.: Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19961404262. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
N2 - The challenge of regulating health claims and food fortification is discussed under the headings: Complex issues in a rapidly changing environment; Regulatory history of folic acid; Interrelationships - health claims and food fortification; General requirements for health claims; Authorising a health claim for folate and neural tube defects; Public health service recommendation; Safety issues - is there a need for concern?; Fortification policy; Safe upper limit of daily intake; Effective dose; Food and Drug Administration's proposed fortification; Food vehicles considered; Food fortification - opportunities and dilemmas; and Current status.
KW - folic acid
KW - foods
KW - fortification
KW - health
KW - nervous system diseases
KW - public health
KW - vitamins
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - folacin
KW - folate
KW - neuropathy
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404262&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Putting things in perspective: building on our experience.
AU - Shank, F. R.
AU - Carson, K.
AU - Glinsmann, W. H.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996///
VL - 126
IS - 3
SP - 781S
EP - 787S
SN - 0022-3166
AD - Shank, F. R.: Food and Drug Administration, U.S. Department of Health and Human Services, Washington, DC 20204, USA.
N1 - Accession Number: 19961404264. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
N2 - The regulation of health claims with respect to folic acid is discussed under the headings: Diet disease and food fortification; Nutrition labelling and education act (NLEA) health claims; Health claim authorization; Health claim criteria; Evolution of the health claim process; Driving forces; Evolving technology; and Wider realm of possibilities.
KW - folic acid
KW - food legislation
KW - health
KW - legislation
KW - vitamins
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - folacin
KW - folate
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961404264&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A program to control an outbreak of hepatitis A in Alaska by using an inactivated hepatitis A vaccine.
AU - McMahon, B. J.
AU - Beller, M.
AU - Williams, J.
AU - Schloss, M.
AU - Tanttila, H.
AU - Bulkow, L.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 1996///
VL - 150
IS - 7
SP - 733
EP - 739
AD - McMahon, B. J.: Alaska Native Medical Center, Alaska Area Native Health Services, Indian Health Service, Anchorage, Alaska 99501, USA.
N1 - Accession Number: 19962007328. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - To stop an epidemic of hepatitis A virus (HAV) infection in rural Alaska, mass immunization of susceptible persons was carried out in a nonrandomized, uncontrolled trial. One dose of a formalin-inactivated hepatitis A vaccine was given to each participant. Adults 20 years of age and older received 1440 ELISA units and persons younger than 20 years received 720 ELISA units. An active surveillance system was established to detect persons with symptomatic illness compatible with hepatitis A; persons who met the illness criteria were tested for anti-HAV IgM. One area (the Kotzebue region), where all communities were offered vaccine, was selected for intensive surveillance and analysis. During the 12-month period before the vaccine trial, 529 cases of icteric hepatitis A were reported, and 443 were confirmed to be positive for anti-HAV IgM. Hepatitis A vaccine was administered to 4930 persons, 3517 of whom were younger than 20 years. After vaccination began, 237 persons positive for antibody to hepatitis A IgM were identified during a 60-week surveillance period; 46 were vaccinees and 191 were unvaccinated susceptible persons. In the Kotzebue region, in communities in which more than 80% of persons considered susceptible were vaccinated, the outbreak ceased in 4-8 weeks, whereas in one large community in which less than 50% of susceptible persons were vaccinated, the outbreak continued for more than 50 weeks. More than 90% of seronegative persons developed anti-HAV IgG 3-4 weeks after vaccination. This trial suggested that by providing both short-term and long-term protection, hepatitis A vaccine used without immune globulin halted an established epidemic of hepatitis A in rural Alaska.
KW - disease control
KW - epidemics
KW - epidemiology
KW - hepatitis A
KW - human diseases
KW - immunization
KW - inactivated vaccines
KW - rural areas
KW - Alaska
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immune sensitization
KW - killed vaccines
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007328&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step.
AU - Oravecz, T.
AU - Pall, M.
AU - Norcross, M. A.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1996///
VL - 157
IS - 4
SP - 1329
EP - 1332
SN - 0022-1767
AD - Oravecz, T.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972000921. Publication Type: Journal Article. Language: English. Number of References: 29 ref.
N2 - The β-chemokines RANTES, MIP-1α, and MIP-1β have potent suppressive effects on HIV-1 infection resulting from an early postbinding block in virus fusion and entry. Inhibition was observed only with monocytotropic isolates and mapped to the V3 region of the HIV-1 envelope. RANTES did not inhibit virus expression in chronically infected cells or reduce initial virus attachment to the cell membrane. Inhibitory activity required RANTES binding to the target cell but not G protein-mediated signalling or protein tyrosine kinase activity. The results are consistent with a reversible competitive mechanism of virus inhibition that prevents a V3-associated postbinding step in membrane fusion. The data support a role for a RANTES chemokine receptor as a coreceptor for monocytotropic HIV-1.
KW - chemokines
KW - cytokines
KW - HIV-1 infections
KW - immune response
KW - immunopathology
KW - inhibition
KW - monocytes
KW - pathogenesis
KW - receptors
KW - tropisms
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000921&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.
AU - Yee, D.
AU - Rhinehart-Jones, T. R.
AU - Elkins, K. L.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1996///
VL - 157
IS - 11
SP - 5042
EP - 5048
SN - 0022-1767
AD - Yee, D.: Laboratory of Enteric and Sexually Transmitted Diseases, Division of Bacterial Products, Center for Biologics Evaluation and Research, Rockville, MD 20852, USA.
N1 - Accession Number: 19970504381. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Medical & Veterinary Entomology
N2 - Normal mice readily survive a sublethal intradermal (i.d.) infection with F. tularensis live vaccine strain (LVS) and are strongly protected against subsequent lethal challenge. However, athymic nu/nu mice, which lack mature αβ TCR+ T lymphocytes, succumb to i.d. infection within 30 days. The authors characterized the αβ T cell subpopulations necessary for both resolution of i.d. infection and generation of optimal protective immunity to LVS. BALB/cByJ mice treated with anti-CD4 or anti-CD8 antibodies before i.d. infection survived and cleared bacteria, and anti-CD4- or anti-CD8-treated immune mice survived a very strong i.p. challenge of 10 000 LD50s. Among mutant mice with targeted gene disruptions (knockouts), CD4-, β2-microglobulin-deficient (which are also CD8-) and γδ TCR- mice all resolved a large sublethal i.d. infection. All CD4- and β2-microglobulin-deficient mice readily survived subsequent lethal i.p. challenge of 10 000 LD50s, even in the absence of specific IgG, as did most (86%) γδ TCR- mice. In contrast, αβ TCR- mice or αβ + γδ TCR- mice died about 35 days after i.d. infection. Depletion of γδ+ T cells from αβ TCR- mice had no effect on mean time to death from i.d. LVS infection. Therefore αβ TCR+ cells are required for protection, but either CD4+ or CD8+ T cells are individually sufficient to resolve a large sublethal i.d. LVS infection and to protect against a maximal secondary lethal challenge. These results emphasize the remarkable plasticity of the αβ T cell response in protective immunity to intracellular bacteria.
KW - antibodies
KW - CD4+ lymphocytes
KW - CD8+ lymphocytes
KW - IgG
KW - immune response
KW - immunity
KW - immunoglobulins
KW - laboratory animals
KW - T lymphocytes
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - CD4+ cells
KW - CD8+ cells
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - nude mice
KW - T cells
KW - T4 lymphocytes
KW - T8 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504381&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CD4-IgG binding threshold for inactivation of human immunodeficiency virus type 1.
AU - Berkower, I.
AU - Mostowski, H.
AU - Bull, T. E.
AU - Murphy, D.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1996///
VL - 173
IS - 4
SP - 863
EP - 869
SN - 0022-1899
AD - Berkower, I.: Laboratory of Immunoregulation, Division of Allergenic Products and Parasitology, Office of Vaccine Research, Center for Biologics, Food and Drug Administration, NIH Campus, Bethesda, MD 20892, USA.
N1 - Accession Number: 19962005225. Publication Type: Journal Article. Language: English. Number of References: 34 ref.
KW - antigen antibody reactions
KW - binding
KW - cd4 antigens
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - inactivation
KW - viral antigens
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - antigenic reactions
KW - CD4
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962005225&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of live, oral poliovirus vaccine monopools for human immunodeficiency virus type 1 and simian immunodeficiency virus.
AU - Khan, A. S.
AU - Shahabuddin, M.
AU - Bryan, T.
AU - Joshi, B. H.
AU - Lee, S.
AU - Hewlett, I. K.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1996///
VL - 174
IS - 6
SP - 1185
EP - 1190
SN - 0022-1899
AD - Khan, A. S.: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA.
N1 - Accession Number: 19972001573. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9068-38-6.
N2 - A total of 12 monovalent lots of live, attenuated oral poliovirus vaccine types 1, 2 and 3, which were released for use by a North American manufacturer during 1976-89, were tested for the presence of HIV-1 and simian immunodeficiency virus (SIV). HIV/SIV were not detected in these monovalent poliovirus vaccine lots with the reverse transcriptase assay, a general detection assay and highly sensitive and specific polymerase chain reaction assays.
KW - analysis
KW - detection
KW - human immunodeficiency viruses
KW - live vaccines
KW - polymerase chain reaction
KW - reverse transcriptase
KW - transmission
KW - vaccines
KW - North America
KW - Human immunodeficiency virus 1
KW - man
KW - monkeys
KW - Poliovirus
KW - simian immunodeficiency virus
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - America
KW - attenuated vaccines
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - human poliovirus
KW - monovalent vaccines
KW - other aspects
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001573&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Induction of murine acquired immunodeficiency syndrome (MAIDS) in allophenic mice generated from strains susceptible and resistant to disease.
AU - Sechler, J. M. G.
AU - Lawler, A.
AU - Hartley, J. W.
AU - Morse, H. C., III
AU - McCarty, T. C.
AU - Swofford, R.
AU - Rosenberg, A. S.
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
Y1 - 1996///
VL - 184
IS - 6
SP - 2101
EP - 2108
SN - 0022-1007
AD - Sechler, J. M. G.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972001533. Publication Type: Journal Article. Language: English. Number of References: 32 ref.
N2 - To examine whether a retroviral disease can be controlled in animals in which cells from a resistant strain coexist in a state of immunological tolerance with cells from a susceptible strain, allophenic mice were constructed and infected with LP-BM5 murine leukaemia viruses which induce a fatal disorder, termed murine acquired immunodeficiency syndrome (MAIDS), characterized by lymphoproliferation and immunodeficiency in susceptible inbred strains of mice. In 2 different strain combinations, resistance to MAIDS was contingent on the presence in individual animals of >50% of lymphocytes of resistant strain origin and correlated with reduction or elimination of retrovirus. In contrast, animals harbouring substantial, but less than predominant, numbers of genetically resistant lymphocytes developed disease and died within the same time frame as susceptible control mice with uncontained proliferation of retrovirus.
KW - genotypes
KW - immunology
KW - induction
KW - leukaemia
KW - lymphocyte transformation
KW - lymphocytes
KW - resistance
KW - strains
KW - mice
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood cancer
KW - leucaemia
KW - leukemia
KW - murine acquired immune deficiency syndrome
KW - other Retroviridae
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972001533&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food and drug administration response.
AU - Altekruse, S.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1996///
VL - 208
IS - 9
SP - 1399
EP - 1399
SN - 0003-1488
AD - Altekruse, S.: Center for Food Safety and Applied Nutrition, FDA, Center for Disease Control and Prevention, M/S A-38, 1600 Clifton Rd, Atlanta, GA 30333, USA.
N1 - Accession Number: 19962211147. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science
KW - administration
KW - bacterial diseases
KW - disease control
KW - disease surveys
KW - food hygiene
KW - food safety
KW - foodborne diseases
KW - infectious diseases
KW - prevention
KW - public health
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - communicable diseases
KW - disease surveillance
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962211147&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developing a model of a professional veterinary drug label.
AU - Martinez, M. N.
AU - Brown, S. A.
AU - Copeland, D. D.
AU - Haibel, G. K.
AU - Koritz, G. D.
AU - Riddell, M. G., Jr.
AU - Riviere, J. E.
AU - Rollins, L. D.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1996///
VL - 209
IS - 1
SP - 83
EP - 91
SN - 0003-1488
AD - Martinez, M. N.: Food and Drug Administration/Center for Veterinary Medicine, 7500 Standish Pl, Rockville, MD 20855, USA.
N1 - Accession Number: 19962214274. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science
KW - drugs
KW - environmental protection
KW - labelling
KW - public health
KW - safety
KW - veterinary products
KW - workshops
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - labeling
KW - labels
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962214274&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of consumer labels for the safety of foods of animal origin.
AU - Altekruse, S. F.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1996///
VL - 209
IS - 12
SP - 2056
EP - 2056
SN - 0003-1488
AD - Altekruse, S. F.: United States Public Health Service, Centers for Disease Control and Prevention, M/S A-38, 1600 Clifton Rd, Atlanta, GA 30333, USA.
N1 - Accession Number: 19972204292. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition; Veterinary Science
KW - food hygiene
KW - food safety
KW - foods
KW - labelling
KW - meat
KW - poultry
KW - domesticated birds
KW - labeling
KW - labels
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972204292&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inducible gene expression of the human immunodeficiency virus LTR in a replication-incompetent herpes simplex virus vector.
AU - Warden, M. P.
AU - Weir, J. P.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1996///
VL - 226
IS - 1
SP - 127
EP - 131
SN - 0042-6822
AD - Warden, M. P.: Laboratory of DNA viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972000237. Publication Type: Journal Article. Language: English. Number of References: 36 ref.
N2 - Using the HIV-1 LTR as a model promoter, it was demonstrated that gene expression can be specifically induced by a non-herpes simplex virus (HSV) transactivating protein. Long-term expression was not achieved however and it is suggested that this could be due to the relatively cytotoxic vectors used, the particular dividing cell lines used or a general limitation of HSV-mediated gene delivery.
KW - cell lines
KW - gene expression
KW - genes
KW - genetics
KW - herpes simplex viruses
KW - human diseases
KW - human herpesviruses
KW - human immunodeficiency viruses
KW - microbiology
KW - vectors
KW - Human immunodeficiency virus 1
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - genomic structure
KW - herpes simplex virus
KW - Human herpesvirus
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - LTR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000237&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A novel acidic allergen, Hev b 5, in latex.
AU - Akasawa, A.
AU - Hsieh LiShan
AU - Martin, B. M.
AU - Liu, T.
AU - Yuan Lin
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 1996///
VL - 271
IS - 41
SP - 25389
EP - 25393
SN - 0021-9258
AD - Akasawa, A.: Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA.
N1 - Accession Number: 19971600609. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Horticultural Science; Plant Breeding; Agricultural Biotechnology
N2 - Latex allergy is recognized as a serious health problem among health care workers and children with spina bifida. A number of IgE-reactive proteins have been identified in natural and processed latex products. One of the most acidic proteins in the cytoplasm of laticifer cells of rubber trees (Hevea brasiliensis) is demonstrated to be a potent allergen in eliciting allergic reactions in humans. This protein, with pI = 3.5, has a molecular mass of 16 kDa with a blocked N terminus and an unusual amino acid composition. This acidic protein was found in extracts prepared from latex gloves, which were shown to be allergenic. The purified protein elicits histamine release from human basophils passively sensitized with serum from latex-allergic individuals in a dose-dependent manner. From a latex cDNA library, the cDNA coding for this protein was isolated and sequenced. The deduced amino acid sequence shows a high degree of homology to another acidic protein identified in kiwifruit (Actinidia deliciosa var. deliciosa). The sequence homology (47% sequence identity) between these two acidic proteins suggests a molecular explanation for the high frequency of fruit hypersensitivity in latex-allergic patients. Nucleotide sequence data have been submitted to the GenBank/EBI databases under accession number U51631.
KW - allergens
KW - amino acid sequences
KW - biotechnology
KW - kiwifruits
KW - latex
KW - nucleotide sequences
KW - rubber plants
KW - Actinidia
KW - Actinidia deliciosa
KW - Hevea brasiliensis
KW - Actinidiaceae
KW - Theales
KW - Ericales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Actinidia
KW - Hevea
KW - Euphorbiaceae
KW - Euphorbiales
KW - DNA sequences
KW - protein sequences
KW - rubber crops
KW - Plant Breeding and Genetics (FF020)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971600609&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serum HIV-1 RNA levels and time to development of AIDS in the multicenter hemophilia cohort study.
AU - O'Brien, T. R.
AU - Blattner, W. A.
AU - Waters, D.
AU - Eyster, M. E.
AU - Hilgartner, M. W.
AU - Cohen, A. R.
AU - Luban, N.
AU - Hatzakis, A.
AU - Aledort, L. M.
AU - Rosenberg, P. S.
AU - Miley, W. J.
AU - Kroner, B. L.
AU - Goedert, J. J.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1996///
VL - 276
IS - 2
SP - 105
EP - 110
SN - 0098-7484
AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Rockville, MD 20852, USA.
N1 - Accession Number: 19962007626. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 63231-63-0.
KW - disease course
KW - haemophilia
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - prognosis
KW - risk groups
KW - RNA
KW - seroconversion
KW - serology
KW - USA
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease progression
KW - hemophilia
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - ribonucleic acid
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962007626&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.
AU - Ambrosone, C. B.
AU - Freudenheim, J. L.
AU - Graham, S.
AU - Marshall, J. R.
AU - Vena, J. E.
AU - Brasure, J. R.
AU - Michalek, A. M.
AU - Laughlin, R.
AU - Nemoto, T.
AU - Gillenwater, K. A.
AU - Harrington, A. M.
AU - Shields, P. G.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1996///
VL - 276
IS - 18
SP - 1494
EP - 1501
SN - 0098-7484
AD - Ambrosone, C. B.: National Center for Toxicological Research, Division of Molecular Epidemiology, 3900 NCTR Rd, Jefferson, AR 72079, USA.
N1 - Accession Number: 19972000962. Publication Type: Journal Article. Language: English. Number of References: 77 ref. Subject Subsets: Public Health
N2 - To determine if N-acetyltransferase 2 (NAT2) polymorphisms result in decreased capacity to detoxify carcinogenic aromatic amines in cigarette smoke, thus making some women who smoke more susceptible to breast cancer, a case-control study with genetic analyses was conducted in New York, USA, involving white women with incident primary breast cancer (n = 304) and community controls (n = 327). DNA analyses were performed for 3 polymorphisms accounting for 90% to 95% of the slow acetylation phenotype among whites. Neither smoking nor NAT2 status was independently associated with breast cancer risk. There were no clear patterns of increased risk associated with smoking by NAT2 status among premenopausal women. In postmenopausal women, NAT2 strongly modified the association of smoking with risk. For slow acetylators, current smoking and smoking in the distant past increased breast cancer risk in a dose-dependent manner (odds ratios [95% confidence intervals] for the highest quartile of cigarettes smoked 2 and 20 years previously, 4.4 [1.3-14.8] and 3.9 [1.4-10.8], respectively). Among rapid acetylators, smoking was not associated with increased breast cancer risk. These results suggest that smoking may be an important risk factor for breast cancer among postmenopausal women who are slow acetylators, demonstrate heterogeneity in response to carcinogenic exposures, and may explain previous inconsistent findings for cigarette smoking as a breast cancer risk factor.
KW - breast
KW - breast cancer
KW - enzymes
KW - genetic polymorphism
KW - human diseases
KW - incidence
KW - neoplasms
KW - risk factors
KW - tobacco smoking
KW - women
KW - New York
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - acetyltransferase
KW - breasts
KW - cancer sites
KW - cancers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Women (UU500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972000962&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Addressing the challenges of emerging infectious diseases.
AU - Pinner, R. W.
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
Y1 - 1996///
VL - 311
IS - 1
SP - 3
EP - 8
SN - 0002-9629
AD - Pinner, R. W.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19960503856. Publication Type: Journal Article. Language: English. Number of References: 23 ref.
KW - bacterial diseases
KW - ehrlichioses
KW - emerging infectious diseases
KW - foodborne diseases
KW - human diseases
KW - infectious diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - communicable diseases
KW - Ehrlichia infections
KW - ehrlichiosis
KW - emerging diseases
KW - emerging infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960503856&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Chronic neurological effects of organophosphate pesticides. Subclinical damage does occur, but longer follow up studies are needed.
AU - Steenland, K.
T2 - British Medical Journal (Clinical Research edition)
JO - British Medical Journal (Clinical Research edition)
JF - British Medical Journal (Clinical Research edition)
Y1 - 1996///
VL - 312
IS - 7042
SP - 1312
EP - 1313
SN - 0959-8138
AD - Steenland, K.: National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 19970502784. Publication Type: Editorial. Language: English. Number of References: 11 ref.
KW - human diseases
KW - nervous system diseases
KW - neurotoxicity
KW - organophosphorus pesticides
KW - poisoning
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - neuropathy
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970502784&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice.
AU - Desai, V. G.
AU - Weindruch, R.
AU - Hart, R. W.
AU - Feuers, R. J.
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
Y1 - 1996///
VL - 333
IS - 1
SP - 145
EP - 151
SN - 0003-9861
AD - Desai, V. G.: National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19981403751. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
KW - age
KW - aging
KW - electron transfer
KW - food restriction
KW - mitochondria
KW - skeletal muscle
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - electron flow
KW - electron transport
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403751&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of fumonisin B1 and (hydrolyzed) fumonisin backbone AP1 on membranes: a spin-label study.
AU - Yin, J. J.
AU - Smith, M. J.
AU - Eppley, R. M.
AU - Troy, A. L.
AU - Page, S. W.
AU - Sphon, J. A.
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
Y1 - 1996///
VL - 335
IS - 1
SP - 13
EP - 22
SN - 0003-9861
AD - Yin, J. J.: Center for Food Safety and Applied Nutrition, US FDA, Washington, DC 20204, USA.
N1 - Accession Number: 19981200832. Publication Type: Journal Article. Language: English. Number of References: 36 ref.
KW - fumonisins
KW - lipids
KW - membranes
KW - mycotoxins
KW - toxicity
KW - fungal toxins
KW - lipins
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200832&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The US Arctic investigations program: infectious disease prevention and control research in Alaska.
AU - Wainwright, R. B.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1996///
VL - 347
IS - 9000
SP - 517
EP - 520
SN - 0140-6736
AD - Wainwright, R. B.: Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Anchorage, Alaska, USA.
N1 - Accession Number: 19962003404. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Public Health
KW - american indians
KW - disease control
KW - disease prevention
KW - ethnic groups
KW - human diseases
KW - infectious diseases
KW - inuit
KW - reviews
KW - Alaska
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - Eskimos
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962003404&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diclazuril.
AU - Mulligan, L. T.
JO - WHO Food Additives Series
JF - WHO Food Additives Series
Y1 - 1996///
IS - 36
SP - 117
EP - 136
CY - Geneva; Switzerland
PB - World Health Organization
SN - 0300-0923
AD - Mulligan, L. T.: Division of Toxicology and Environmental Sciences, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19960805720. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 101831-37-2. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Protozoology
N2 - This monograph summarizes the safety data on diclazuril residues which were reviewed by the Joint FAO/WHO Expert Committee on Food Additives which met in Geneva, Switzerland, in June 1995. This anticoccidial has not previously been considered by the committee. Biological data (biochemical aspects, absorption, distribution and excretion) and toxicological studies (acute, short-term, long-term, and reproductive toxicity, embryotoxicity, teratogenicity, genotoxicity, observations in humans, microbiological properties and pharmacological effects) were reviewed.
KW - antiprotozoal agents
KW - coccidiostats
KW - diclazuril
KW - drug residues
KW - food
KW - food additives
KW - parasites
KW - reviews
KW - toxicity
KW - man
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - anticoccidials
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19960805720&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology and neuroepidemiology of human immunodeficiency virus infection.
AU - Janssen, R. S.
A2 - Berger, J. R.
A2 - Levy, R. M.
T2 - AIDS and the nervous system.
JO - AIDS and the nervous system.
JF - AIDS and the nervous system.
Y1 - 1996///
IS - Ed. 2
SP - 13
EP - 37
CY - Philadelphia; USA
PB - Lippincott-Raven Publishers
SN - 0781703093
AD - Janssen, R. S.: Division of HIV/AIDS Prevention, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19972007312. Publication Type: Miscellaneous. Language: English. Number of References: 243 refs.
KW - acquired immune deficiency syndrome
KW - epidemiology
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - nervous system diseases
KW - pathogenesis
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - neuropathy
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007312&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - U.S. public health service guidelines for testing and counseling blood and plasma donors for human immunodeficiency virus type 1 antigen.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
IS - RR-2
SP - 1
EP - 9
SN - 0149-2195
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19962008374. Publication Type: Miscellaneous. Corporate Author: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention. Language: English. Number of References: 22 ref.
KW - algorithms
KW - blood donors
KW - core protein p24
KW - counselling
KW - guidelines
KW - HIV-1 infections
KW - human diseases
KW - plasma
KW - testing
KW - USA
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - counseling
KW - human immunodeficiency virus type 1
KW - p24
KW - p24 antigen
KW - recommendations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19962008374&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Guidelines for school health programs to promote lifelong healthy eating.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1996///
IS - RR-9
SP - iii + 41
EP - iii + 41
SN - 0149-2195
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
N1 - Accession Number: 19961410191. Publication Type: Annual report. Corporate Author: USA, Department of Health and Human Services Language: English. Number of References: 229 ref. Subject Subsets: Human Nutrition
N2 - This report summarizes strategies most likely to be effective in promoting healthy eating among school-age adolescents and provides nutrition education guidelines for a comprehensive school health programme. These guidelines are based on a review of research, theory and current practice, and they were developed by the US Centers for Disease Control in collaboration with experts from universities and from national, federal and voluntary agencies. The guidelines include recommendations on 7 aspects of a school-based programme to promote healthy eating: school policy on nutrition, a sequential, coordinated curriculum, appropriate instruction for students, integration of school food service and nutrition education, staff training, family and community involvement, and programme evaluation.
KW - children
KW - guidelines
KW - health
KW - nutrition education
KW - nutrition programmes
KW - school children
KW - school meals
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - nutrition programs
KW - recommendations
KW - school kids
KW - schoolchildren
KW - United States of America
KW - Education, Extension, Information and Training (General) (CC000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961410191&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Evaluation of toxicological studies on Flavr Savr® tomato.
AU - Hattan, D.
T2 - Food safety evaluation. Proceedings of an OECD-sponsored workshop held on 12-15 September 1994, Oxford, UK.
JO - Food safety evaluation. Proceedings of an OECD-sponsored workshop held on 12-15 September 1994, Oxford, UK.
JF - Food safety evaluation. Proceedings of an OECD-sponsored workshop held on 12-15 September 1994, Oxford, UK.
Y1 - 1996///
SP - 58
EP - 60
CY - Paris; France
PB - Organisation for Economic Cooperation and Development (OECD)
SN - 9264148671
AD - Hattan, D.: United States Food and Drug Administration, USA.
N1 - Accession Number: 19961610094. Publication Type: Conference paper. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - Some of the studies performed in rats by Calgene to find evidence to support of the safety of the new transgenic Flavr Savr® tomatoes are briefly discussed.
KW - biosafety
KW - biotechnology
KW - genetic engineering
KW - genetic transformation
KW - genetically engineered organisms
KW - histopathology
KW - ripening
KW - risk
KW - tomatoes
KW - toxicity
KW - transgenic plants
KW - plants
KW - Solanum
KW - Solanum lycopersicum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Food safety evaluation
KW - genetic manipulation
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GMOs
KW - Lycopersicon
KW - Lycopersicon esculentum
KW - transgenic organisms
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19961610094&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Dye residues in foods of animal origin.
AU - Roybal, J. E.
AU - Pfenning, A. P.
AU - Turnipseed, S. B.
AU - Hurlbut, J. A.
AU - Long, A. R.
A2 - Moats, W. A.
A2 - Medina, M. B.
T2 - Veterinary drug residues: food safety. Developed by a symposium at the 209th National Meeting of the American Chemical Society, Anaheim, California, April 2-7, 1995.
JO - Veterinary drug residues: food safety. Developed by a symposium at the 209th National Meeting of the American Chemical Society, Anaheim, California, April 2-7, 1995.
JF - Veterinary drug residues: food safety. Developed by a symposium at the 209th National Meeting of the American Chemical Society, Anaheim, California, April 2-7, 1995.
Y1 - 1996///
SP - 169
EP - 183
CY - Washington; USA
PB - American Chemical Society
SN - 0841234191
AD - Roybal, J. E.: Animal Drugs Research Center, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19971412683. Publication Type: Conference paper. Language: English. Number of References: 34 ref. Registry Number: 548-62-9, 569-64-2, 61-73-4. Subject Subsets: Human Nutrition
N2 - Dyes are used for numerous purposes, including animal husbandry and aquaculture. Food destined for human consumption could contain residues of these compounds and unnecessary exposure to dye residues has the potential for human health hazards. This chapter examines methodology used to detect and identify several commonly used dye, their residues and metabolites. Discussion focuses on matrices and methods used and developed in the author's laboratory as well as work of other investigators. The metabolism, analysis and confirmation of Gentian Violet (GV), Malachite Green (MG) and Methylene Blue (MB) by HPLC, LC/MS and GC/MS are covered. Information discussed includes: GV metabolized in chickens, yielding demethylated and reduced products; analysis of GV-incurred chicken tissue, 3 h post-dosing, revealing 20-105 ppb GV total residues; chicken fat yielding 49.3 ppb of Leucogentian Violet, the main metabolite; analysis of MG-incurred catfish, 24 h post-dosing, produced average residues of 289 ppb Leucomalachite Green as the predominant metabolite; and MB in milk was metabolized to the completely demethylated product, thionin, 26.6 ppb, 72 h post-dosing.
KW - animal husbandry
KW - anthelmintics
KW - antibacterial agents
KW - antifungal agents
KW - antiseptics
KW - consumption
KW - drug residues
KW - drugs
KW - dyes
KW - food contamination
KW - fungicides
KW - gentian violet
KW - health
KW - malachite green
KW - metabolites
KW - methylene blue
KW - poultry
KW - residues
KW - veterinary products
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 209th National Meeting of the American Chemical Society
KW - animal health products
KW - chickens
KW - crystal violet
KW - domesticated birds
KW - dyestuffs
KW - food contaminants
KW - fungistats
KW - livestock husbandry
KW - medicines
KW - methylrosanilinium
KW - methylthioninium chloride
KW - pharmaceuticals
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Eggs and Egg Products (QQ040)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412683&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology, molecular.
AU - Schulte, P. A.
AU - Perera, F. P.
AU - Rothman, N.
A2 - Myers, R. A.
T2 - Encyclopedia of molecular biology and molecular medicine Volume 2: Denaturation of DNA to growth factors.
JO - Encyclopedia of molecular biology and molecular medicine Volume 2: Denaturation of DNA to growth factors.
JF - Encyclopedia of molecular biology and molecular medicine Volume 2: Denaturation of DNA to growth factors.
Y1 - 1996///
SP - 258
EP - 262
CY - Weinheim; Germany
PB - VCH Verlagsgesellschaft mbH
SN - 3527284729
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cinncinati, OH 45226, USA.
N1 - Accession Number: 19972007457. Publication Type: Miscellaneous. Language: English. Number of References: 10 ref.
N2 - The principles and techniques of molecular epidemiology are discussed, including biological markers of exposure, effect and susceptibility, utility of molecular epidemiology, representational validity of molecular biological markers, validation of the behaviour of molecular biological markers, aetiological studies, and public health applications.
KW - aetiology
KW - epidemiological surveys
KW - epidemiology
KW - human diseases
KW - markers
KW - techniques
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - causal agents
KW - etiology
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007457&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Risk assessment strategies for hormones and hormone-like substances.
AU - Miller, M. A.
AU - Leighton, J. K.
T2 - Scientific conference on growth promotion in meat production. Proceedings Brussels, Belgium 29 November to 1 December 1995.
JO - Scientific conference on growth promotion in meat production. Proceedings Brussels, Belgium 29 November to 1 December 1995.
JF - Scientific conference on growth promotion in meat production. Proceedings Brussels, Belgium 29 November to 1 December 1995.
Y1 - 1996///
SP - 383
EP - 399
CY - Luxembourg; Luxembourg
PB - Commission of the European Communities
SN - 9282763218
AD - Miller, M. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19972200473. Publication Type: Conference paper. Language: English. Number of References: 35 ref. Registry Number: 56-53-1, 9002-72-6. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Veterinary Science
N2 - A review of risk assessment for the use of growth promoters in the USA including diethylstilbestrol, endogenous steroid hormones (oestrogen, progesterone and testosterone), synthetic steroids and non-steroidal hormone-like agents (trenbolone, melengestrol, zeranol and phytoestrogens), somatotropin (Sometribove) and\beta-agonists.
KW - adverse effects
KW - androgens
KW - diethylstilbestrol
KW - drug residues
KW - growth promoters
KW - oestrogens
KW - public health
KW - somatotropin
KW - toxicity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - beta-agonists
KW - diethylstilboestrol
KW - estrogens
KW - growth hormone
KW - growth stimulants
KW - stilboestrol
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972200473&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food lipids and health.
A2 - McDonald, R. E.
A2 - Min, D. B.
T2 - Food lipids and health.
Y1 - 1996///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824797124
AD - National Center for Food Safety and Technology, Food and Drug Administration Summit-Argo, Illinois, USA.
N1 - Accession Number: 19971407327. Publication Type: Book. Language: English. Number of References: IFT Basic Symposium Series No. 11; many ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - This book provides an in-depth discussion of recent developments in lipid chemistry and nutrition and how these developments affect the food industry. The major lipid health issues are presented including dietary recommendations, atherosclerosis, cancer, immune response, and bone health. The more controversial issues discussed include health effects of saturated fat, trans fatty acids, fat substitutes, cholesterol oxidation products, and frying oils. Other discussions include lipid contributions to flavour and functionality, enzyme modification of lipids, natural antioxidants, and evaluation of lipid quality and stability. Recent developments concerning the use of lipids in food products are described, including the application of plant biotechnology to edible oils, current developments of fat substitutes, and the use of lipids in medical and designer foods. New findings are described regarding biochemical and physiological factors that affect dietary lipid intake in man.
KW - antioxidants
KW - atherosclerosis
KW - bones
KW - cholesterol
KW - cooking oils
KW - flavour
KW - food industry
KW - frying
KW - functional foods
KW - health
KW - immune response
KW - lipid substitutes
KW - lipids
KW - neoplasms
KW - oils
KW - oxides
KW - saturated fats
KW - trans fatty acids
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arteriosclerosis
KW - cancers
KW - flavor
KW - immunity reactions
KW - immunological reactions
KW - lipins
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407327&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Trans fatty acids: labeling, nutrition, and analysis.
AU - McDonald, R. E.
AU - Mossoba, M. M.
A2 - McDonald, R. E.
A2 - Min, D. B.
T2 - Food lipids and health.
Y1 - 1996///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824797124
AD - McDonald, R. E.: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Illinois, USA.
N1 - Accession Number: 19971407332. Publication Type: Book chapter. Language: English. Number of References: 107 ref. Subject Subsets: Human Nutrition
N2 - The process of catalytic hydrogenation of vegetable and marine oils dramatically changes their composition by producing many geometric and positional isomers. Although no specific adverse effects on human health have been proven for these isomers, it has been shown that they are incorporated into most organs and tissues. Fatty acid isomers can influence enzyme activity and other biochemical reactions. However, it is not known if these influences cause any short-or long-term beneficial or harmful physiological effects. Unfortunately, careful selection of published data can still be used to provide evidence of the absolute safety or the adverse physiological effects of hydrogenated oils. It is, therefore, important to continue to conduct more comprehensive studies to better define the physiological properties of the isomeric fatty acids in hydrogenated oils. It is also important to continue to develop improved methods to accurately and conveniently determine total trans as well as specific fatty acid isomers in hydrogenated oils.
KW - fish oils
KW - hydrogenated oils
KW - isomers
KW - labelling
KW - plant oils
KW - safety
KW - trans fatty acids
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - labeling
KW - labels
KW - vegetable oils
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407332&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Organic dust toxic syndrome.
AU - Sorenson, W. G.
AU - Lewis, D. M.
A2 - Howard, D. H.
A2 - Miller, J. D.
T2 - The Mycota. A comprehensive treatise on fungi as experimental systems for basic and applied research. Volume VI: Human and animal relationships.
Y1 - 1996///
CY - Berlin; Germany
PB - Springer-Verlag
SN - 3540580077
AD - Sorenson, W. G.: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19961200684. Publication Type: Book chapter. Language: English. Number of References: 4 pp. of ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Organic dust toxic syndrome (ODTS) is reviewed, including the composition of organic dust, fungi associated with ODTS, current concepts of aetiology of ODTS and the potential role of fungal spores (mycotoxins, cell wall composition and spore diffusates and whole spores).
KW - allergies
KW - contamination
KW - dust
KW - hosts
KW - human diseases
KW - mycotoxins
KW - respiratory diseases
KW - reviews
KW - spores
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - fungal toxins
KW - lung diseases
KW - organic dust toxic syndrome
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Toward a regulatory method: comparison and validation of multiresidue procedures for determination of βlactam antibiotics in milk.
AU - Carson, M. C.
AU - Chu PakSin
AU - Bredow, J. von
A2 - Moats, W. A.
A2 - Medina, M. B.
T2 - Veterinary drug residues: food safety. Developed by a symposium at the 209th National Meeting of the American Chemical Society, Anaheim, California, April 2-7, 1995.
Y1 - 1996///
CY - Washington; USA
PB - American Chemical Society
SN - 0841234191
AD - Carson, M. C.: Center for Veterinary Medicine, U.S. Food and Drug Administration, BARC-East, Building 328A, Beltsville, MD 20705, USA.
N1 - Accession Number: 19972208618. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 5 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Dairy Science
N2 - Intramammary infusion of β-lactam antibiotics is often used to treat mastitis in lactating dairy cattle. Failure to follow label guidelines for dosage or milk discard time may result in residues of these drugs (amoxicillin, ampicillin, cloxacillin, cephapirin and penicillin G) entering the raw milk bulk tank. Under the U.S. Pasteurized Milk Ordinance, industry must now monitor each milk tanker for β-lactams before accepting the milk for processing. Several screening tests are currently accepted by the Food and Drug Administration (FDA) for use in this programme. Screening tests are designed to pass safe milk, a negative result indicates that the milk contains no unsafe residues of the drugs the test detects. By themselves, screening tests generally do not meet FDA criteria for a regulatory method. Use of a regulatory determinative procedure ensures that milk testing positive by a screening test contains illegal drug residues. Several procedures developed by other laboratories for suitability as part of a regulatory method were examined. Evaluation criteria included: (1) number of residues detected at their tolerance/safe levels, (2) accuracy, (3) precision, (4) ruggedness, and (5) practicability. The procedures studied include (1) a 2-dimensional liquid chromatographic (LC) assay developed by W.A. Moats; (2) a liquid-liquid extraction procedure employing diazomethane derivatization followed by capillary gas chromatography developed in the laboratory of M. Petz; (3) a "receptorgram" assay developed by Charm Sciences Inc.; and (4) an LC procedure using pre-column derivatization with triazole/HgCl2 developed by J. Boison. A comparison of these procedures and validation results are presented.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - beta-lactam antibiotics
KW - biological techniques
KW - bulk milk
KW - chemical analysis
KW - detection
KW - drug residues
KW - legislation
KW - liquid chromatography
KW - milk
KW - milk hygiene
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972208618&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of diuretic drugs used in food-producing animals.
AU - Shaikh, B.
A2 - Moats, W. A.
A2 - Medina, M. B.
T2 - Veterinary drug residues: food safety. Developed by a symposium at the 209th National Meeting of the American Chemical Society, Anaheim, California, April 2-7, 1995.
Y1 - 1996///
CY - Washington; USA
PB - American Chemical Society
SN - 0841234191
AD - Shaikh, B.: Center of Veterinary Medicine, U.S. Food and Drug Administration, BARC-East, Building 328A, Beltsville, MD 20705, USA.
N1 - Accession Number: 19972208613. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 22 ref. Registry Number: 58-94-6, 54-31-9, 58-93-5. Subject Subsets: Animal Nutrition; Human Nutrition; Veterinary Science; Dairy Science
N2 - Thiazide diuretics (chlorothiazide, hydrochlorothiazide, and trichlormethiazide) and a loop diuretic (furosemide) are used in dairy cattle for the treatment of post-parturient oedema of the mammary gland and associated structures. The potential misuse of these diuretics in the cattle may lead to harmful residue concentrations in meat and milk for human consumption. Therefore, analytical methods which are sufficiently sensitive to monitor residue concentration levels remain an urgent need for these diuretics. Various research approaches described in the literature for the extraction, isolation, and quantitation of diuretics in biological matrices with emphasis on the liquid chromatographic determinative procedures are reviewed.
KW - analytical methods
KW - antibiotic residues
KW - chemical analysis
KW - chlorothiazide
KW - determination
KW - diuretics
KW - drug residues
KW - drugs
KW - food hygiene
KW - furosemide
KW - hydrochlorothiazide
KW - meat hygiene
KW - milk
KW - milk hygiene
KW - oedema
KW - reviews
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - edema
KW - medicines
KW - pharmaceuticals
KW - trichlormethiazide
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972208613&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA overview and current challenges in regulation of human subject protection.
AU - Nightingale, S. L.
JO - Journal of the International Association of Physicians in AIDS care
JF - Journal of the International Association of Physicians in AIDS care
Y1 - 1997///
VL - 3
IS - 1
SP - 24
EP - 26
AD - Nightingale, S. L.: Food and Drug Administration, USA.
N1 - Accession Number: 19982002296. Publication Type: Journal Article. Language: English.
KW - acquired immune deficiency syndrome
KW - clinical trials
KW - ethics
KW - guidelines
KW - human diseases
KW - human immunodeficiency viruses
KW - patients
KW - policy
KW - protection
KW - treatment
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus
KW - recommendations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002296&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric Toxin Protein.
AU - Husain, S. R.
AU - Obiri, N. I.
AU - Gill, P.
AU - Zheng Tong
AU - Pastan, I.
AU - Debinski, W.
AU - Puri, R. K.
JO - Clinical Cancer Research
JF - Clinical Cancer Research
Y1 - 1997///
VL - 3
IS - 2
SP - 151
EP - 156
AD - Husain, S. R.: Correspondence address [Puri, R. K.]: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Building 29B, Room 2NN10, 29 Lincoln Drive, MSC 4555, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972005714. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 148157-34-0.
N2 - A new target was identified in the form of an interleukin 13 (IL-13) receptor that is overexpressed in the five AIDS-KS cell lines examined. Radiolabelled IL-13 cross-linked to a single protein of about Mr 70 000 in AIDS-KS cells. A chimeric cytotoxic protein composed of IL-13 and a truncated Pseudomonas exotoxin (IL13-PE38QQR) was used and found to be specifically and highly cytotoxic to AIDS-KS cells, as determined by protein synthesis inhibition and clonogenic assays. IL13-PE38QQR demonstrated significant antitumour activity in a human epidermoid carcinoma xenograft model. Normal human umbilical vein-derived endothelial, lymphoid, and bone marrow precursor cells expressed low levels of IL-13 receptors, and IL-13 toxin was not cytotoxic to them. Thus, IL-13 receptor on AIDS-KS cells may represent a novel plasma membrane protein(s) that could be utilized to target therapeutic agents.
KW - acquired immune deficiency syndrome
KW - antineoplastic agents
KW - antiviral agents
KW - antiviral properties
KW - blood plasma
KW - carcinoma
KW - cell lines
KW - cytokines
KW - cytotoxicity
KW - exotoxins
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - immunotherapy
KW - inhibition
KW - interleukin 13
KW - interleukins
KW - Kaposi's sarcoma
KW - lymphocytes
KW - malignant course
KW - microbiology
KW - neoplasms
KW - plasma membranes
KW - precursors
KW - protein synthesis
KW - receptors
KW - sarcoma
KW - surface antigens
KW - synthesis
KW - toxins
KW - treatment
KW - Human immunodeficiency virus 1
KW - Pseudomonas
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - AIDS
KW - anti-viral properties
KW - bacterium
KW - cancers
KW - cell membrane
KW - cytotoxic agents
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - immunotoxins
KW - plasma (blood)
KW - plasmalemma
KW - protein biosynthesis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005714&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Commentary: safety/risk assessment of neurodevelopmental toxins in food.
AU - Bolger, M.
JO - Mental Retardation and Developmental Disabilities Research Reviews
JF - Mental Retardation and Developmental Disabilities Research Reviews
Y1 - 1997///
VL - 3
IS - 3
SP - 275
EP - 278
AD - Bolger, M.: Contaminants Branch, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19981403830. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The process by which the U.S. Food and Drug Administration evaluates the public health implications of potential neurotoxic substances including those that elicit neurodevelopmental effects are discussed.
KW - evaluation
KW - food contamination
KW - foods
KW - legislation
KW - neurotoxins
KW - toxicity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403830&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permuted interleukin-4 and Pseudomonas exotoxin.
AU - Husain, S. R.
AU - Gill, P.
AU - Kreitman, R. J.
AU - Pastan, I.
AU - Puri, R. K.
JO - Molecular Medicine
JF - Molecular Medicine
Y1 - 1997///
VL - 3
IS - 5
SP - 327
EP - 338
AD - Husain, S. R.: Correspondence address [Puri, R. K.]: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health-Bldg 29B, Rm 2NN10, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972006974. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 207137-56-2.
N2 - The expression of interleukin-4 receptors (IL-4R) on AIDS-Kaposi's sarcoma (KS) cells and their subunit structure was determined by radioligand receptor binding cross-linking and Northern and RT-PCR analyses. The in vitro effect of IL-4 and recombinant fusion protein made up of circularly permuted IL-4 and a mutated form of Pseudomonas exotoxin IL-4(38-37)-PE38KDEL was examined by clonogenic and protein synthesis inhibition assays. Five AIDS-KS cell lines expressed high-affinity IL-4R with a Kd of 23.5-219 pM. IL-4 appeared to crosslink to one major protein corresponding to 140 kDa and a broad band corresponding to 60-70 kDa. Both cross-linked proteins were immunoprecipitated with an antibody to human IL-4Rβ chain. AIDS-KS cells exhibited IL-4Rβ-specific mRNA. IL-4 caused a modest inhibition (31-34%) of colony formation in two AIDS-KS cell lines tested. IL-4(38-37)-PE38KDEL was found to be highly effective in inhibiting the protein synthesis in all five AIDS-KS examined. The IC50 ranged from 32 to 1225 pM. The cytotoxic action of IL-4 toxin was blocked by an excess of IL-4 exhibiting the specificity of IL-4(38-37)-PE38KDEL. The cytotoxicity of IL-4 toxin observed by a clonogenic assay corroborated well with the IC50 obtained by protein synthesis inhibition assay. Normal human endothelial cells expressed a negligible number of IL-4R (<50 sites/cell) and were less sensitive or not sensitive to IL-4(38-37)-PE38KDEL.
KW - antibodies
KW - antineoplastic agents
KW - binding
KW - cell lines
KW - cytotoxicity
KW - drug therapy
KW - effects
KW - endothelium
KW - exotoxins
KW - fusion proteins
KW - in vitro
KW - inhibition
KW - interleukin 4
KW - Kaposi's sarcoma
KW - neoplasms
KW - protein synthesis
KW - proteins
KW - receptors
KW - sarcoma
KW - structure
KW - synthesis
KW - toxins
KW - treatment
KW - man
KW - Pseudomonas
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - cancers
KW - chemotherapy
KW - cytotoxic agents
KW - endothelial cells
KW - protein biosynthesis
KW - specificity
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006974&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection.
AU - Zaitseva, M.
AU - Blauvelt, A.
AU - Lee, S.
AU - Lapham, C. K.
AU - Klaus-Kovtun, V.
AU - Mostowski, H.
AU - Manischewitz, J.
AU - Golding, H.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 1997///
VL - 3
IS - 12
SP - 1369
EP - 1375
AD - Zaitseva, M.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29B, Rm 4NN04, HFM 454, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19982002024. Publication Type: Journal Article. Language: English. Number of References: 43 ref.
N2 - Transmission of HIV-1 is predominantly restricted to macrophage-tropic strains. Langerhans cells (LCs) in mucosal epithelium, as well as macrophages located in the submucosal tissues, may be initial targets for HIV-1. This study was designed to determine whether restricted transmission of HIV-1 correlates with expression and function of HIV-1 co-receptors on LCs and macrophages. Using polyclonal rabbit IgGs specific for the HIV co-receptors cytokines CXCR4 and CCR5, it was found that freshly isolated epidermal LCs (resembling resident mucosal LCs) expressed CCR5, but not CXCR, on their surfaces. In concordance with surface expression, fresh LCs fused with macrophage-tropic but not with T-lymphocyte-tropic HIV-1 envelopes. However, fresh LCs did contain intracellular CXCR4 protein that was transported to the surface during in vitro culture. Macrophages expressed high levels of both co-receptors on their surfaces, but only CCR5 was functional in a fusion assay. These data provide several possible explanations for the selective transmission of macrophage-tropic HIV variants and for the resistance to infection conferred by the CCR5 deletion.
KW - chemokines
KW - cytokines
KW - human diseases
KW - human immunodeficiency viruses
KW - in vitro
KW - infection
KW - macrophages
KW - mucosa
KW - pathogenesis
KW - receptors
KW - transmission
KW - tropisms
KW - Human immunodeficiency virus 1
KW - man
KW - rabbits
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - Langerhans cells
KW - mucous membrane
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002024&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Agricultural health and safety: recent advances. Part 1. Proceedings of the third NIOSH agricultural health and safety conference, March 25-26, 1996, Iowa City, IA. Edited by Donham, K. J., Rautiainen, R., Schuman, S. H. and Lay, J. A.
T2 - Journal of Agromedicine
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 1997///
VL - 4
IS - 1/2
SP - 176
EP - 176
CY - New York; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - National Institute for Occupational Safety and Health, Atlanta, GA, USA.
N1 - Accession Number: 19972402097. Publication Type: Conference proceedings. Corporate Author: USA, National Institute for Occupational Safety and Health Language: English. Subject Subsets: Agricultural Engineering
N2 - This is the first part of the 2 part [USA] National Institute for Occupational Safety and Health conference proceedings, containing sections on Program reports (3 papers), Airborne exposure, lung disease, exposure assessment (7 papers), Training, intervention, communication (6 papers) and Pesticides, ergonomics, priority assessment (4 papers).
KW - health
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Agricultural health and safety: recent advances: part 1
KW - United States of America
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972402097&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Agricultural health and safety: recent advances. Part II. Proceedings of the third NIOSH agricultural health and safety conference, March 25-26, 1996, Iowa City, IA. Edited by Donham, K. J., Rautiainen, R., Schuman, S. H. and Lay, J. A.
T2 - Journal of Agromedicine
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 1997///
VL - 4
IS - 3/4
SP - 237
EP - 237
SN - 1059-924X
AD - National Institute for Occupational Safety and Health, Atlanta, GA, USA.
N1 - Accession Number: 19972402096. Publication Type: Conference proceedings. Corporate Author: Journal of Agromedicine Language: English. Subject Subsets: Agricultural Engineering
N2 - This [USA] National Institute for Occupational Safety and Health conference proceedings contains sections on Stress, mental health, risk assessment, community health (8 papers), Injury, enforcement, machinery (8 papers) and Poster presentations (7 papers).
KW - health
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Agricultural health and safety: recent advances: part II
KW - United States of America
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972402096&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of undeclared prescription drugs in Black Pearl products.
AU - Fraser, D. B.
AU - Tomlinson, J.
AU - Turner, J.
AU - Satzger, R. D.
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
Y1 - 1997///
VL - 5
IS - 4
SP - 329
EP - 335
SN - 1021-9498
AD - Fraser, D. B.: Food and Drug Administration, Forensic Chemistry Center, Cincinnati, Ohio, USA.
N1 - Accession Number: 19980304879. Publication Type: Journal Article. Language: English. Language of Summary: Chinese. Number of References: 14 ref. Registry Number: 53-86-1. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - Black Pearls are a type of Chinese herbal preparation generally marketed to American consumers suffering from arthritis and back pain. Their importation and sale in the USA has been banned by the Food and Drug Administration since the 1970s. However, they are still available by mail order and occasionally in specialty shops. The FDA is concerned over the use of Black Pearls because some products have been adulterated with undeclared prescription drugs. Using a combination of GC-MS and HPLC to analyse methanol/ether extracts of Black Pearl products, the following prescription drugs: diazepam, diclofenac, hydrochlorothiazide, indometacin and mefenamic acid have been detected. The levels and combinations of drugs present varied significantly, even within the same manufacturer and the presence or absence of the drugs was not consistent within different packages of the same product. Because of the adulteration and lack of control in the contents of these products, the FDA is actively trying to stop the sale and use of Black Pearls in the USA.
KW - adulterants
KW - adulteration
KW - analytical methods
KW - drugs
KW - GC-MS
KW - herbal drugs
KW - HPLC
KW - indometacin
KW - medicinal plants
KW - medicinal properties
KW - quality
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - Black Pearls
KW - drug plants
KW - gas chromatography-mass spectrometry
KW - herbal medicines
KW - high performance liquid chromatography
KW - indomethacin
KW - medicinal herbs
KW - medicines
KW - officinal plants
KW - pharmaceuticals
KW - United States of America
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980304879&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phylogenetic relationships of the Culicomorpha inferred from 18S and 5.8S ribosomal DNA sequences (Diptera: Nematocera).
AU - Miller, B. R.
AU - Crabtree, M. B.
AU - Savage, H. M.
JO - Insect Molecular Biology
JF - Insect Molecular Biology
Y1 - 1997///
VL - 6
IS - 2
SP - 105
EP - 114
SN - 0962-1075
AD - Miller, B. R.: Virus and Vector Molecular Biology Section, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970501113. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The evolutionary origins of the mosquito family Culicidae were investigated by examination of 18S and 5.8S ribosomal gene sequence divergence. Phylogenetic analyses demonstrated that within the infraorder Culicomorpha, taxa in the families Corethrellidae, Chaoboridae and Culicidae formed a monophyletic group; there was support for a sister relationship between this lineage and a representative of the Chironomidae. A chaoborid midge was the closest relative of the mosquitoes. Taxa from 4 genera of mosquitoes formed a monophyletic group; lack of a spacer in the 5.8S gene was unique to members of the Culicidae. A member of the genus Anopheles formed the most basal lineage among the mosquitoes analysed. Phylogenetic relationships were unresolved for representatives in the families Dixidae, Simuliidae and Ceratopogonidae. The GenBank accession numbers for the gene sequences and presumed gene boundaries found during this study are U48377-U48385 and U49735-U49736, and the alignments deposited with EMBL are DS24888 and DS24865 for the 18S and 5.8S rDNA sequence alignments, respectively.
KW - evolution
KW - molecular genetics
KW - nucleotide sequences
KW - phylogeny
KW - ribosomal dna
KW - Ceratopogonidae
KW - Chaoboridae
KW - Chironomidae
KW - Culicidae
KW - Diptera
KW - Simuliidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - blackflies
KW - buffalo gnats
KW - Corethrellidae
KW - Culicomorpha
KW - DNA sequences
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501113&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A method to estimate the percent loss of cytosine methyl groups at defined CPG sites in liver DNA from methyl-deficient rats.
AU - Pogribny, I. P.
AU - James, S. J.
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
Y1 - 1997///
VL - 8
IS - 6
SP - 355
EP - 359
SN - 0955-2863
AD - Pogribny, I. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971410736. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 62-49-7, 71-30-7, 9007-49-2, 59-30-3, 63-68-3. Subject Subsets: Human Nutrition
N2 - Weanling male F344 rats were given a semipurified diet deficient in choline, methionine and folic acid for 36 weeks with sampling intervals at 3, 9, 24 and 36 weeks. Using a genomic sequencing procedure based on the PCR amplification of bisulfite-modified DNA, the methylation status of individual CpG sites within exons 6 and 7 of the p53 gene in liver samples from control and deficient rats was assessed. Treatment of denatured nuclear DNA with sodium bisulfite converts unmethylated cytosine residues to uracil, which are then amplified as thymine in the PCR reaction. In contrast, methylated cytosines are resistant to bisulfite deamination under these reaction conditions and are amplified as cytosine. A novel application of automated sequencing technology to estimate the proportion of methylated cytosines present at defined CpG sites within the total population of DNA molecules extracted is described. Using the bisulfite conversion-PCR genomic sequencing method, the validity of peak height analysis of co-eluting peaks in the autosequencer electrophoregram to estimate the percent methylation at a defined CpG site was demonstrated. The sensitivity of this method is demonstrated by the progressive loss of methyl groups at a defined CpG site in the methyl-deficient rats after 9, 24 and 36 weeks. The application of this sequence-specific technology will allow site-specific definition of the methylation status of each CpG site within a coding sequence or promoter region and should provide new insights into mechanisms and consequences of methylation dysregulation as a result of dietary deprivation of methyl donors.
KW - amino acids
KW - analytical methods
KW - choline
KW - cytosine
KW - dna
KW - folic acid
KW - groups
KW - lipotropic factors
KW - liver
KW - methionine
KW - methylation
KW - polymerase chain reaction
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - deoxyribonucleic acid
KW - folacin
KW - folate
KW - lipotropes
KW - lipotropic factor deficiency
KW - PCR
KW - Techniques and Methodology (ZZ900)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410736&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interleukin-4 receptor expression in vivo on human AIDS-related Kaposi's sarcoma.
AU - Varricchio, F.
AU - Rafat Husain, S.
AU - Leland, P.
AU - Gill, P.
AU - Puri, R. K.
JO - Oncology Research
JF - Oncology Research
Y1 - 1997///
VL - 9
IS - 9
SP - 495
EP - 503
SN - 0965-0407
AD - Varricchio, F.: Laboratory of Molecular Tumor Biology, HFM-530, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, NIH-Building 29B, Room 2NN10, 29 Lincoln Drive MSC 4555, Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 19982005364. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Registry Number: 207137-56-2.
N2 - The results of this study suggest that AIDS-Kaposi's sarcoma (KS) cells express elevated levels of interleukin-4 receptor compared to normal endothelial and skin cells and thus the receptors for interleukin-4 on KS cells may serve as an attractive target for anticancer therapy.
KW - acquired immune deficiency syndrome
KW - cells
KW - human diseases
KW - human immunodeficiency viruses
KW - interleukin 4
KW - Kaposi's sarcoma
KW - receptors
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - human immunodeficiency virus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005364&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Chemokine receptors and HIV-2.
AU - Heredia, A.
AU - Vallejo, A.
AU - Soriano, V.
AU - Epstein, J. S.
AU - Hewlett, I. K.
T2 - AIDS
JO - AIDS
JF - AIDS
Y1 - 1997///
VL - 11
IS - 9
SP - 1198
EP - 1199
SN - 0269-9370
AD - Heredia, A.: Laboratory of Molecular Virology, Division of Transfusion and Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19972005852. Publication Type: Correspondence. Language: English. Number of References: 12 ref.
N2 - Peripheral blood mononuclear cells were obtained from 10 HIV-2-seropositive individuals of African origin. None of the subjects was coinfected with HIV-1. Virus isolation by cocultivation was successful in 8 cases. Three of the positive cultures were classified as syncytium-inducing (SI). The results showed that the NSI isolates of HIV-2 could use the chemokine receptor CCR-5 for entry into cells. Also similar to HIV-1, SI isolates of HIV-2 could use CXCR-4 in addition to CCR-5. However, in contrast to primary isolates of HIV-1, all SI solates of HIV-2 could also use the CCR-1 and CCR-2b receptors. These differences in coreceptor usage between primary isolates of HIV-1 and HIV-2 should be taken into account in the design of therapeutic approaches for each of these viruses.
KW - CD4+ lymphocytes
KW - CD8+ lymphocytes
KW - cells
KW - chemokines
KW - cytokines
KW - HIV infections
KW - human diseases
KW - immune response
KW - immunology
KW - phenotypes
KW - receptors
KW - syncytia
KW - uptake
KW - Human immunodeficiency virus 1
KW - Human immunodeficiency virus 2
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - CD4+ cells
KW - CD8+ cells
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - human immunodeficiency virus type 2
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - T8 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005852&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients.
AU - Styrt, B. A.
AU - Chaisson, R. E.
AU - Moore, R. D.
JO - AIDS
JF - AIDS
Y1 - 1997///
VL - 11
IS - 10
SP - 1243
EP - 1248
SN - 0269-9370
AD - Styrt, B. A.: Center for Drug Evaluation and Research, Food and Drug Administration, HFD-530, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19972006495. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 72559-06-9.
N2 - This study was performed to delineate relationships between prior use of antimicrobials and Staphylococcus aureus bacteraemia. To compare prior exposure to selected antimicrobial drugs in patients who had S. aureus bacteraemia and in controls who did not, a nested case-control study was conducted within a cohort of HIV-infected persons followed in an outpatient clinic. Using a computerized database based on HIV clinic records, 48 cases with S. aureus bacteraemia were compared against 188 controls selected from patients with CD4+ cell counts <200 × 106/l. Injecting drug use was strongly associated with S. aureus bacteraemia. Rifabutin use was associated with decreased risk of S. aureus bacteraemia [conditional relative risk (RR) 0.308, 95% confidence interval (CI) 0.096-0.991] in univariate analysis, near statistical significance in multivariate analysis (RR 0.314, 95% CI 0.096-1.023). The bacteraemias were not significantly associated with use of trimethoprim-sulfamethoxazole, quinolones, newer macrolides (azithromycin and clarithromycin), clindamycin or dapsone.
KW - acquired immune deficiency syndrome
KW - antibacterial agents
KW - antiinfective agents
KW - antimicrobial properties
KW - bacteraemia
KW - CD4 antigens
KW - CD4+ lymphocytes
KW - databases
KW - demography
KW - drug abuse
KW - drugs
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - infections
KW - information
KW - injecting drug abuse
KW - injection
KW - leukocyte count
KW - macrolide antibiotics
KW - opportunistic infections
KW - patients
KW - prophylaxis
KW - relationships
KW - rifabutin
KW - risk factors
KW - treatment
KW - man
KW - Staphylococcus
KW - Staphylococcus aureus
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Staphylococcus
KW - AIDS
KW - anti-microbial properties
KW - antimicrobials
KW - bacteremia
KW - bacterium
KW - CD4
KW - CD4+ cells
KW - cell count
KW - data banks
KW - drug use
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - i.v. drug abuse
KW - i.v. drug use
KW - medicines
KW - pharmaceuticals
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006495&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Liposomal daunorubicin is not recommended in patients with less than advanced HIV-related Kaposi's sarcoma.
AU - White, R. M.
T2 - AIDS
JO - AIDS
JF - AIDS
Y1 - 1997///
VL - 11
IS - 11
SP - 1412
EP - 1413
SN - 0269-9370
AD - White, R. M.: Division of Oncology Drug Products FDA, Center for Drug Evaluation and Research, HFD-150, Rockville, Maryland, USA.
N1 - Accession Number: 19972007746. Publication Type: Correspondence. Language: English. Number of References: 1 ref.
N2 - The correspondent questions the improvements in survival in patients with early Kaposi's sarcoma that were attributed by Uthayakumar et al. (AIDS (1996) 10 515-519) to treatment with liposomal daunorubicin. Addition is drawn to the Food and Drug Administration-approved prescribing information for DaunoXome (liposomal daunorubicin), which does not recommend it in patients with less than advanced HIV-related Kaposi's sarcoma.
KW - acquired immune deficiency syndrome
KW - antineoplastic agents
KW - cytotoxicity
KW - drug therapy
KW - guidelines
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - Kaposi's sarcoma
KW - liposomes
KW - neoplasms
KW - survival
KW - treatment
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - cancers
KW - chemotherapy
KW - cytotoxic agents
KW - daunorubicin
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - recommendations
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007746&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Demand for and use of advacacy services for persons living with HIV/AIDS.
AU - Hines, R.
AU - Decker, C. L.
AU - Witt, W. P.
AU - Marconi, K.
AU - Singer, B.
JO - AIDS and Public Policy Journal
JF - AIDS and Public Policy Journal
Y1 - 1997///
VL - 12
IS - 2
SP - 89
EP - 101
SN - 0887-3852
AD - Hines, R.: Office of Science and Epidemiology, Bureau of Health Resources Development, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD, USA.
N1 - Accession Number: 19972010739. Publication Type: Journal Article; Annual report; Journal article. Corporate Author: Four Special Projects of National Significance HIV Advocacy Projects Language: English. Number of References: 5 ref.
N2 - This article examines 4 locally administered HIV-advocacy programs during the 3-year period from late 1991 through September 1994 funded by the federal Special Projects of National Significance (SPNS) Program. Each of the 4 advocacy projects-the Indiana HIV Advocacy Program (IHAP); the Massachusetts AIDS Discrimination Initiative, Inc. (MADI); the Protection and Advocacy System, Inc. of New Mexico; and the Michigan Protection and Advocacy Service HIV/AIDS Advocacy Project (HAAP)-established a model for providing statewide HIV-related legal protection and advocacy services. Specifically, this article highlights project strategies to approaching HIV-advocacy services, and summarizes outreach services, self-advocacy services, case-advocacy services for individuals, capacity building, system-level advocacy, and the characteristics of the projects' clients and services. The authors obtained information for the article from interviews with project staff and from annual reports submitted by the 4 projects.
KW - acquired immune deficiency syndrome
KW - community care
KW - discrimination
KW - health care
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - information
KW - law
KW - patients
KW - treatment
KW - Indiana
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - legal aspects
KW - legal principles
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010739&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The adequacy of reimbursement for HIV under Section 1115 Medicaid waivers.
AU - Conviser, R.
AU - Kerrigan, D.
AU - Thompson, S.
JO - AIDS and Public Policy Journal
JF - AIDS and Public Policy Journal
Y1 - 1997///
VL - 12
IS - 3
SP - 112
EP - 127
SN - 0887-3852
AD - Conviser, R.: Service Evaluation and Research Branch, Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD USA.
N1 - Accession Number: 19982005767. Publication Type: Journal Article. Language: English. Number of References: 29 ref.
N2 - This study was designed to investigate the extent to which managed-care organizations (MCOs) in Medicaid managed-care programs may be put at financial risk by caring for people living with HIV (PLWH). It examines the capitation rates paid to MCOs in the nine states with Section 1115 Medicaid demonstration programmes that were in operation as of mid-1996. Those rates are compared with recent estimates for fee-for-service Medicaid expenditures for HIV care; likely shifts in the cost of care as a result of the 1996 introduction of protease inhibitor combination therapy also are discussed. This costly therapeutic regimen promises to slow and even reverse the progression of HIV disease in many people who are already infected. The comparison of capitation rates with the actual cost of care will indicate the extent of financial risk that faces Medicaid MCOs caring for disproportionate shares of PLWH.
KW - antiviral agents
KW - combination therapy
KW - costs
KW - disease course
KW - funding
KW - health care
KW - health services
KW - human immunodeficiency viruses
KW - proteinase inhibitors
KW - treatment
KW - USA
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - combined modality therapy
KW - costings
KW - disease progression
KW - human immunodeficiency virus
KW - multimodal treatment
KW - protease inhibitors
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005767&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - UVB and PUVA therapies in HIV patients: are they safe?
AU - Beer, J. Z.
AU - Zmudzka, B. Z.
JO - Photodermatology Photoimmunology & Photomedicine
JF - Photodermatology Photoimmunology & Photomedicine
Y1 - 1997///
VL - 13
IS - 3
SP - 91
EP - 92
AD - Beer, J. Z.: Food and Drug Administration, FDA, HFZ-114, Rockville, MD 20857, USA.
N1 - Accession Number: 19982000141. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
N2 - The knowledge of UV-induced phenomena that may affect progression of HIV disease is limited. It is particularly important to focus future studies and analyses on the effects of UV on HIV disease in its early/middle stage. Such data not only will provide information of importance for a potentially sensitive patient population, but also will shed light on the possible effects of non-clinical, i.e., cosmetic, recreational, and environmental UV exposure on HIV infection. Current rapid progress in photoimmunology will certainly contribute to further development in this area.
KW - disease course
KW - environment
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - information
KW - safety
KW - therapy
KW - treatment
KW - ultraviolet radiation
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - disease progression
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - therapeutics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000141&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heme peroxidase activity measured in single mosquitoes identifies individuals expressing an elevated oxidase for insecticide resistance.
AU - Brogdon, W. G.
AU - McAllister, J. C.
AU - Vulule, J.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1997///
VL - 13
IS - 3
SP - 233
EP - 237
SN - 8756-971X
AD - Brogdon, W. G.: Entomology Branch F-22, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Diseases Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980500191. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 903-99-0, 14875-96-8, 52645-53-1. Subject Subsets: Medical & Veterinary Entomology
N2 - Optimum conditions are described for a simple, rapid microplate-based assay that indirectly measures the differences in oxidase levels between individual susceptible, resistant or induced mosquitoes. A small proportion (0.01-0.1) of a single mosquito is used, allowing multiple replicates of the oxidase assay. Cytochrome C is used as a positive control. The levels of oxidase found in sample populations of pyrethroid (permethrin) -susceptible, pyrethroid-resistant and phenobarbital-induced Anopheles albimanus are characterized with the assay.
KW - bioassays
KW - biochemistry
KW - enzyme activity
KW - haem
KW - insecticide resistance
KW - oxidoreductases
KW - permethrin
KW - peroxidase
KW - pyrethroid insecticides
KW - techniques
KW - Culicidae
KW - Diptera
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - heme
KW - mosquitoes
KW - redox enzymes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500191&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evidence of HIV-2 infection in equatorial Guinea (Central Africa): partial genetic analysis of a B subtype virus.
AU - Heredia, A.
AU - Vallejo, A.
AU - Soriano, V.
AU - Gutierrez, M.
AU - Puente, S.
AU - Epstein, J. S.
AU - Hewlett, I. K.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1997///
VL - 13
IS - 5
SP - 439
EP - 440
SN - 0889-2229
AD - Heredia, A.: Laboratory of Molecular Virology, Division of Transfusion and Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19972004660. Publication Type: Journal Article. Language: English. Number of References: 9 ref.
KW - epidemiology
KW - HIV-2 infections
KW - human diseases
KW - nucleotide sequences
KW - phylogenetics
KW - Equatorial Guinea
KW - Human immunodeficiency virus 2
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Central Africa
KW - Africa South of Sahara
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - DNA sequences
KW - human immunodeficiency virus type 2
KW - viral subtypes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004660&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic analysis of an HIV type 2 subtype B virus from a Spanish individual with AIDS.
AU - Heredia, A.
AU - Vallejo, A.
AU - Soriano, V.
AU - Aguilera, A.
AU - Mas, A.
AU - Epstein, J. S.
AU - Hewlett, I. K.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1997///
VL - 13
IS - 10
SP - 899
EP - 900
SN - 0889-2229
AD - Heredia, A.: Laboratory of Molecular Virology, Division of Transfusion and Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. Correspondence address [Heredia, A.]: C/Martin de los Heros, 67, 28008 Madrid, Spain.
N1 - Accession Number: 19972006879. Publication Type: Journal Article. Language: English. Number of References: 14 ref.
KW - acquired immune deficiency syndrome
KW - case reports
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - molecular biology
KW - molecular genetics
KW - Spain
KW - Human immunodeficiency virus 2
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - AIDS
KW - biochemical genetics
KW - human immunodeficiency virus type 2
KW - subtypes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006879&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Outline of the life of Stoll.
AU - Jackson, G. J.
JO - Parasitology Today
JF - Parasitology Today
Y1 - 1997///
VL - 13
IS - 11
SP - 409
EP - 409
AD - Jackson, G. J.: US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19980803727. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
KW - biographies
KW - helminthology
KW - helminths
KW - history
KW - human diseases
KW - parasites
KW - parasitology
KW - Norman Stoll
KW - parasitic worms
KW - Stoll
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803727&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selenium supplementation suppresses tumor necrosis factor α-induced human immunodeficiency virus type 1 replication in vitro.
AU - Hori, K.
AU - Hatfield, D.
AU - Maldarelli, F.
AU - Lee, B. J.
AU - Clouse, K. A.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1997///
VL - 13
IS - 15
SP - 1325
EP - 1332
SN - 0889-2229
AD - Hori, K.: Division of Cytokine Biology, Centers for Biologics Evaluation and Research (HFM-508) Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 19972009894. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 308079-78-9, 70-18-8, 7782-49-2. Subject Subsets: Human Nutrition
N2 - In this study it is shown that selenium supplementation partially suppresses the TNF-α-mediated enhanced replication of HIV-1 in vitro in acutely infected monocytes, as well as in chronically infected T lymphocytes and monocytes. The finding that in vitro selenium supplementation increases glutathione peroxidase activity is confirmed and it is demonstrated that thioredoxin reductase activity is also increased. These results suggest that selenium supplementation is important for AIDS patients with documented selenium deficiency and that therapies using selenium in combination with antiviral drugs and/or other antioxidants may prove to be more beneficial.
KW - acquired immune deficiency syndrome
KW - antiviral agents
KW - cytokines
KW - deficiency
KW - drugs
KW - glutathione
KW - HIV-1 infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunology
KW - in vitro
KW - inhibition
KW - lymphocytes
KW - mineral deficiencies
KW - necrosis
KW - patients
KW - replication
KW - selenium
KW - supplementary feeding
KW - T lymphocytes
KW - tumour necrosis factor
KW - viral replication
KW - Human immunodeficiency virus 1
KW - man
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - cachectin
KW - cachexin
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - medicines
KW - pharmaceuticals
KW - T cells
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009894&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic variability of HIV type 1 in Honduras.
AU - Candal, D. H.
AU - Pau, C. P.
AU - Luo, C. C.
AU - Granade, T.
AU - Stetler, H.
AU - Amador, L.
AU - Meza, R.
AU - Nunez, C.
AU - Schochetman, G.
AU - George, J. R.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1997///
VL - 13
IS - 15
SP - 1349
EP - 1350
SN - 0889-2229
AD - Candal, D. H.: Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19972009897. Publication Type: Journal Article. Language: English. Number of References: 7 ref.
N2 - Although Honduras represents only 15% of the Central American population, the country has almost 60% of the region's AIDS cases. There have been 4973 cases of full-blown AIDS reported in the country. The Health Ministry reports that more than 8000 Hondurans have been infected with HIV since the first Honduran case was diagnosed in 1985, and that 995 have died. This study was designed to examine the HIV-1 subtype present in Honduras and to determine the degree of genetic variation among HIV-1 strains by analysing viral nucleotide sequences from the envelope region of HIV-1 isolates obtained from the two most affected regions of the country. From the data presented, all 27 Honduran isolates belong to subtype B, and they are genetically more related to North American-European HIV-1 isolates than to African isolates.
KW - acquired immune deficiency syndrome
KW - amino acid sequences
KW - epidemiology
KW - genetic variation
KW - HIV-1 infections
KW - human diseases
KW - human immunodeficiency viruses
KW - nucleotide sequences
KW - nucleotides
KW - phylogenetics
KW - strains
KW - variation
KW - Honduras
KW - Human immunodeficiency virus 1
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - AIDS
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - protein sequences
KW - viral subtypes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009897&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethyl carbamate levels resulting from azodicarbonamide use in bread.
AU - Cañas, B. J.
AU - Diachenko, G. W.
AU - Nyman, P. J.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1997///
VL - 14
IS - 1
SP - 89
EP - 94
SN - 0265-203X
AD - Cañas, B. J.: Division of Natural Products (HFS-347), US Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971405021. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 51-79-6. Subject Subsets: Human Nutrition
KW - bread
KW - carbamates
KW - carcinogens
KW - flours
KW - food additives
KW - toasting
KW - urethane
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - azodicarbonamide
KW - ethyl carbamate
KW - ethylurethane
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405021&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of HIV infection of H9 cells by chlorpromazine derivatives.
AU - Hewlett, I.
AU - Lee, S.
AU - Molnar, J.
AU - Foldeak, S.
AU - Pine, P. S.
AU - Weaver, J. L.
AU - Aszalos, A.
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1 - 1997///
VL - 15
IS - 1
SP - 16
EP - 20
AD - Hewlett, I.: Correspondence address [Aszalos, A.] Division of Research and Testing, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19972006893. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 50-53-3, 69-09-0.
N2 - The binding between the HIV surface protein, gp120, and the CD4 co-receptor is known to be initiated by electrostatic interactions. Because of the ability of chlorpromazine to interact with proteins by charge transfer, several derivatives were tested for their ability to block binding of HIV to CD4+ cells. It was shown that 7,8-dioxo-chlorpromazine blocks binding of fluorescein isothiocyanate-labelled anti Leu3a and rgp120 to peripheral human blood T4 cells and blocks syncytia formation between gp120- and CD4-expressing cells. It was also found that 7,8-dioxo-chlorpromazine blocks HIV infectivity of H9 cells and acts synergistically with zidovudine.
KW - CD4 antigens
KW - CD4+ lymphocytes
KW - chlorpromazine
KW - derivatives
KW - formation
KW - HIV infections
KW - human immunodeficiency viruses
KW - infection
KW - infectivity
KW - microbiology
KW - proteins
KW - syncytia
KW - uptake
KW - Human immunodeficiency virus 1
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - aminazine
KW - CD4
KW - CD4+ cells
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006893&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plants as bioreactors for biopharmaceuticals: regulatory considerations.
AU - Miele, L.
JO - Trends in Biotechnology
JF - Trends in Biotechnology
Y1 - 1997///
VL - 15
IS - 2
SP - 45
EP - 50
SN - 0167-7799
AD - Miele, L.: Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, Department of Health and Human Services, Food and Drug Administration, NIH Building 29B, Room 3NN06, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 19971602796. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Agricultural Biotechnology
N2 - Recombinant DNA technology is being used to produce biological macromolecules in crop plants for pharmaceutical applications. This brief overview of the subject concentrates on general principles that can be applied in the regulation of the manufacture and testing of recombinant biological macromolecules produced in plants for pharmaceutical use. The paper addresses potential applications and production strategies, genetic stability of expression systems, production of biological macromolecules free from contamination by microorganisms, purity of recombinant products, activity of plant-derived recombinant products in comparison to their counterparts produced by traditional methods, and the environmental impact of transgenic crops expressing biological macromolecules.
KW - biosafety
KW - biotechnology
KW - crops
KW - drugs
KW - environmental impact
KW - genetic engineering
KW - genetic transformation
KW - genetically engineered organisms
KW - legislation
KW - pharmaceutical proteins
KW - purity
KW - regulations
KW - transgenic plants
KW - plants
KW - eukaryotes
KW - environmental effects
KW - genetic manipulation
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - medicines
KW - pharmaceuticals
KW - rules
KW - therapeutic proteins
KW - transgenic organisms
KW - Plant Breeding and Genetics (FF020)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971602796&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Induction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin.
AU - Yang ChunFu
AU - Collins, W. E.
AU - Xiao LiHua
AU - Saekhou, A. M.
AU - Reed, R. C.
AU - Nelson, C. O.
AU - Hunter, R. L.
AU - Jue, D. L.
AU - Fang, S. N.
AU - Wohlhueter, R. M.
AU - Venkatachalam Udhayakumar
AU - Lal, A. A.
JO - Vaccine
JF - Vaccine
Y1 - 1997///
VL - 15
IS - 4
SP - 377
EP - 386
SN - 0264-410X
AD - Yang ChunFu: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Service, Atlanta, GA 30341, USA.
N1 - Accession Number: 19980802482. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 21645-51-2. Subject Subsets: Protozoology
N2 - This paper reports an immunization study in Saimiri boliviensis boliviensis monkeys, using a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite (CS) protein repeat region and a T helper epitope of tetanus toxin, formulated in different adjuvants. Monkeys immunized 3 times with MAC in copolymer P1005, P1005 plus RaLPS (detoxified lipopolysaccharide), or MF-75 (a mixture of substances) had titres of antibodies against CS repeat, sporozoites and the protective B epitope AGDR in the CS repeats significantly higher than those immunized with MAC in alum or PBS (phosphate-buffered saline) (P<0.05). Antibody levels in animals that received P1005 were maintained at a high level for 7 months after the last immunization. Upon challenge with 10 000 sporozoites 2 weeks after the last immunization, 3 of 4 monkeys in the alum group, 3 of 6 in the P1005 plus RaLPS group, 2 of 5 in the P1005 group, 2 of 6 in the MF-75 group, and one of 6 in the MAC-alone group were fully protected. When immunized animals were challenged again with 30 000 sporozoites 22 weeks after the last immunization (having been treated with antimalarials 10 weeks earlier), 2 of 5 in the P1005 group were fully protected. The remaining 3 in this group developed low parasitaemia (<2000 parasites mm-3 of blood) after significantly longer prepatent periods (P<0.05) than in the MF-75 or PBS groups. In addition, one of 6 monkeys from each of the P1005 plus RaLPS and MF-75 groups was also fully protected. Protected animals had higher levels of prechallenge anti-AGDR antibody titres than unprotected animals (although the difference was only significant for the 2nd challenge): 1933 vs 281 for the first challenge, (P>0.05); 21527 vs 196 for the rechallenge, (P<0.05). Anti-AGDR antibody titres were positively correlated with the prepatent period of infected animals, but again this was not significant for the first challenge (r=0.42 for the first challenge, P>0.05; r=0.60 for the rechallenge, P<0.05); they were negatively correlated with the peak parasitaemia (r= -0.39 for the first challenge, P<0.05; r= -0.50 for the rechallenge, P<0.05). These results suggest that when combined with the use of potent adjuvants and T helper epitopes, MAC subunit vaccines may offer protection against malaria infection.
KW - adjuvants
KW - aluminium hydroxide
KW - animal diseases
KW - antibodies
KW - antigens
KW - epitopes
KW - experimental infections
KW - human diseases
KW - immune response
KW - immunization
KW - laboratory animals
KW - laboratory mammals
KW - lipopolysaccharides
KW - malaria
KW - parasites
KW - recombinant vaccines
KW - tetanus toxoid
KW - vaccine development
KW - vaccines
KW - monkeys
KW - Plasmodium vivax
KW - protozoa
KW - Saimiri boliviensis
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Saimiri
KW - Cebidae
KW - aluminum hydroxide
KW - antigenic determinants
KW - antigenicity
KW - circumsporozoite proteins
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Saimiri boliviensis boliviensis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802482&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parasites of fish and risks to public health.
AU - Adams, A. M.
AU - Murrell, K. D.
AU - Cross, J. H.
JO - Revue Scientifique et Technique - Office International des Épizooties
JF - Revue Scientifique et Technique - Office International des Épizooties
Y1 - 1997///
VL - 16
IS - 2
SP - 652
EP - 660
AD - Adams, A. M.: United States Food and Drug Administration, P.O. Box 3012, 22201 23rd Drive S.E., Bothell, Washington, DC 98041-3012, USA.
N1 - Accession Number: 19980805236. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Helminthology
N2 - This general account of the most important of the helminths acquired by humans from fish covers anisakid nematodes (particularly Anisakis simplex and Pseudoterranova decipiens), cestodes of the genus Diphyllobothrium and digenetic trematodes of the families Heterophyidae, Opisthorchiidae and Nanophyetidae. Risk mitigation and preventive measures are outlined.
KW - disease transmission
KW - epidemiology
KW - fish
KW - foodborne diseases
KW - helminths
KW - human diseases
KW - parasites
KW - public health
KW - reviews
KW - Anisakis simplex
KW - Digenea
KW - Diphyllobothrium
KW - Heterophyidae
KW - man
KW - Nanophyetidae
KW - Opisthorchiidae
KW - Pseudoterranova decipiens
KW - Anisakis
KW - Anisakidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Trematoda
KW - Platyhelminthes
KW - Diphyllobothriidae
KW - Eucestoda
KW - Cestoda
KW - Digenea
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pseudoterranova
KW - Ascaridida
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980805236&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vegetable concentrates interact with canthaxanthin to affect carotenoid bioavailability and superoxide dismutase activity but not immune response in rats.
AU - Brown, E. D.
AU - Blakely, S. R.
AU - Babu, U.
AU - Grundel, E.
AU - Mitchell, G. V.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 1997///
VL - 17
IS - 6
SP - 989
EP - 998
SN - 0271-5317
AD - Brown, E. D.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19971406222. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 514-78-3, 502-65-8, 9054-89-1, 127-40-2. Subject Subsets: Human Nutrition
N2 - Tomato paste and dried spinach powder were examined as dietary sources of lycopene and lutein and their interactions with canthaxanthin (CX) in water-soluble beadlets were also examined. Mature male Sprague-Dawley rats (n=10/group) were fed on a standard diet containing 16% fat and CX 2 g/kg from beadlets (+CX) or placebo beadlets (-CX) for 8 weeks. Tomato paste or spinach powder was added to each of these diets at 0, 5 (low tomato, low spinach) and 15% (w/w) (high tomato, high spinach). The low and high levels of tomato paste and spinach powder contained lycopene 0.03 and 0.09 g and lutein 0.02 and 0.06 g/kg diet, respectively. High tomato decreased liver CX concentrations 5-fold and plasma CX 2-fold; low tomato had no effect. Liver lycopene concentrations increased as the concentration of tomato paste increased in the diet. However, feeding CX dramatically decreased liver lycopene concentrations. Feeding high tomato and -CX lowered liver superoxide dismutase activity. Neither dietary carotenoids nor CX treatment altered mitogenic response of splenic mononuclear cells to concanavalin or lipopolysaccharide. It was concluded that, in rats, a carotenoid-rich food may influence the availability of a carotenoid supplement. Likewise, supplementation with a single purified carotenoid may antagonize the availability of carotenoids in food matrices.
KW - availability
KW - blood
KW - canthaxanthin
KW - carotenoids
KW - diet
KW - enzyme activity
KW - enzymes
KW - immune response
KW - interactions
KW - liver
KW - lycopene
KW - placebos
KW - sources
KW - spinach
KW - superoxide dismutase
KW - tomatoes
KW - vitamins
KW - xanthophyll
KW - rats
KW - Solanum
KW - Solanum lycopersicum
KW - Spinacia oleracea
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Solanum
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - immunity reactions
KW - immunological reactions
KW - lutein
KW - Lycopersicon
KW - Lycopersicon esculentum
KW - tetraterpenoids
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971406222&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.
AU - James, S. J.
AU - Miller, B. J.
AU - Basnakian, A. G.
AU - Pogribny, I. P.
AU - Pogribna, M.
AU - Muskhelishvili, L.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1997///
VL - 18
IS - 2
SP - 287
EP - 293
SN - 0143-3334
AD - James, S. J.: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971412569. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Registry Number: 62-49-7, 9007-49-2, 59-30-3, 63-68-3, 53-84-9. Subject Subsets: Human Nutrition
N2 - Weanling male F344 rats were fed on a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for 2, 5, 7 days, 3 weeks and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidence of apoptotic bodies, identified by in situ end-labeling of 3'-OH DNA strand breaks, was significantly increased in liver sections from the deficient rats. Apoptotic cell death was confirmed by an increase in nuclear Ca2+/Mg2+ -dependent endonuclease activity that paralleled the increase in apoptotic bodies over the 9-week feeding period. There was no morphological evidence of necrotic foci or necrosis-associated inflammatory response over the 9-week period. Confirming that cell turnover is chronically elevated in this model, the increase in apoptotic rate was accompanied by a sustained increase in the mitotic index. The DNA repair-associated enzyme, poly(ADPribose) polymerase, was similarly elevated and was associated with significant decreases in the substrate for ADPribose polymer synthesis, nicotinamide adenine dinucleotide. Because folate metabolites are essential for de novo purine and thymidine synthesis, prolonged deficiency in folic acid can induce an imbalance in the deoxynucleotide precursors for DNA replication/repair and negatively affect the fidelity of DNA synthesis. Using an HPLC method, hepatic deoxyuridine triphosphate levels were increased at 3 and 9 weeks after initiation of the deficient diet and levels of thymidine triphosphate were reduced. An increase in dUTP/ dTTP ratio is consistent with a block in folate-dependent de novo thymidylate synthesis and may predispose to uracil misincorporation and DNA repair-related DNA strand breaks.
KW - amino acids
KW - apoptosis
KW - choline
KW - deficiency
KW - DNA
KW - enzyme activity
KW - enzymes
KW - folic acid
KW - liver
KW - methionine
KW - NAD
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - folacin
KW - folate
KW - nicotinamide adenine dinucleotide
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971412569&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prenatal fumonisin (FB1) treatment in rats results in minimal maternal or offspring toxicity.
AU - Ferguson, S. A.
AU - St. Omer, V. E. V.
AU - Kwon, O. S.
AU - Holson, R. R.
AU - Houston, R. J.
AU - Rottinghaus, G. E.
AU - Slikker, W., Jr.
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 1997///
VL - 18
IS - 2
SP - 561
EP - 569
SN - 0160-2748
AD - Ferguson, S. A.: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981201140. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The neurobehavioural and developmental effects of fumonisin B1 (FB1) were investigated in Sprague-Dawley rats treated with FB1 on gestational days 13-20. In Experiment 1, FB1 was obtained from Fusarium moniliforme [Gibberella fujikuroi] culture material and 30 pregnant rats were gavaged with 0, 0.8 or 1.6 mg/kg. In Experiment 2, 44 pregnant rats were gavaged with purified FB1 at doses of 0, 1.6 or 9.6 mg/kg. Offspring were evaluated on a battery of behavioural tests as well as measures of whole and regional brain weight. There were no effects on maternal weight gain, reproductive outcomes or offspring body weight through adulthood in either experiment. Complex maze performance, open field and running wheel activity were not altered by prenatal FB1 treatment. In Experiment 2, acoustic startle response was depressed at 2 ages during the first or second block of 9 trials in males treated with purified FB1. Females exhibited no such alterations. Play behaviour at postnatal day (PND) 33, but not PND 26, was increased in males prenatally treated with 9.6 mg/kg relative to those treated with 1.6 mg/kg. There were no substantive treatment effects on regional brain weight. It is suggested that doses of ≤9.6 mg/kg purified FB1 and/or ≤1.6 mg FB1/kg obtained from culture material cause minimal maternal toxicity and produce few developmental functional alterations. In addition, potential FB1-related functional alterations were evident only in males providing further support for a mild sex-specific effect for fumonisin.
KW - fetal development
KW - fumonisins
KW - mycotoxicoses
KW - mycotoxins
KW - neurotoxicity
KW - poisoning
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - mycotoxin poisoning
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201140&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni.
AU - Bosshardt, S. C.
AU - Freeman, G. L., Jr.
AU - Secor, W. E.
AU - Colley, D. G.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 1997///
VL - 19
IS - 8
SP - 347
EP - 353
SN - 0141-9838
AD - Bosshardt, S. C.: Immunology Branch, Division of Parasitic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA.
N1 - Accession Number: 19970804146. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 207137-56-2. Subject Subsets: Helminthology
N2 - Twenty weeks after moderate level infections with Schistosoma mansoni, ~ 20% of male CBA/J mice develop hypersplenomegaly syndrome (HSS) while the rest present with moderate splenomegaly syndrome (MSS). HSS and MSS mice differ pathophysiologically (degree of splenomegaly, anaemia, ascites, periportal fibrosis, portal hypertension) and immunologically (idiotypic expression, isotype levels) to schistosome soluble egg antigens (SEA) and in spleen cell phenotypic profiles. In vitro proliferative responses and interleukin (IL)-2, interferon (IFN)-γ, IL-4 and IL-10 production by spleen cells from uninfected mice and mice with acute (8 week), MSS or HSS schistosomiasis mansoni on exposure to anti-CD3ε or SEA were compared. Spleen cells from uninfected mice produced IL-2 to anti-CD3ε but exposure of cells from all 3 groups of infected mice to anti-CD3ε or SEA led to only very low levels of supernatant IL-2. Anti-CD3ε- or SEA-stimulated production of IFN-γ or IL-4, and anti-CD3ε-stimulated production of IL-10, displayed similar patterns: the highest cytokine production was by cells from mice with acute infections, and the two chronic groups produced lower levels of similar magnitude. In contrast, while SEA-stimulated IL-10 production was again highest with cells from mice with acute infections, spleen cells from mice with MSS produced significantly more IL-10 than did those from mice with HSS. This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation associated with chronic schistosomiasis.
KW - acute course
KW - antigens
KW - chronic course
KW - experimental infections
KW - helminths
KW - immune response
KW - immunopathology
KW - interferon
KW - interleukin 10
KW - interleukin 2
KW - interleukin 4
KW - laboratory animals
KW - parasites
KW - pathology
KW - schistosomiasis
KW - spleen
KW - splenomegaly
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - antigenicity
KW - bilharzia
KW - bilharziasis
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - immunopathogenesis
KW - parasitic worms
KW - schistosomosis
KW - severe course
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reductive voltammetric HPLC detection of aflatoxins: determination of aflatoxin B1 in foods.
AU - Holak, W.
AU - DiProssimo, V.
AU - Malek, E. G.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1997///
VL - 20
IS - 7
SP - 1057
EP - 1065
AD - Holak, W.: U. S. Food and Drug Administration, New York Regional Laboratory, Brooklyn, NY 11232, USA.
N1 - Accession Number: 19971201165. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Postharvest Research
N2 - A reductive voltammetric detector, consisting of static mercury drop electrode, was investigated for possible determination of aflatoxins B1, B2, G1 and G2 by HPLC. The HPLC system consisted of a C18 ODS column and a mobile phase composed of 30% acetonitrile and 0.01 M tetrabutylammonium bromide. The detector was operated in a differential pulse mode, set to the peak potential of -1.25 volts vs. Ag/AgCl. Under these conditions the sensitivity of the system was sufficient to determine aflatoxin B1 present in several foods. The detection limit for aflatoxin B1 was 2.5 ng/g. Good agreement was obtained between this method and TLC.
KW - aflatoxins
KW - analytical methods
KW - contamination
KW - determination
KW - estimation
KW - foods
KW - HPLC
KW - mycotoxins
KW - analytical techniques
KW - fungal toxins
KW - high performance liquid chromatography
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Science and Food Products (Human) (QQ000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of all-rac-α-tocopheryl acetate, tocopherols, and retinyl palmitate in SRM 1846.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1997///
VL - 20
IS - 20
SP - 3317
EP - 3327
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, 60 Eighth Street, Atlanta, GA, USA.
N1 - Accession Number: 19980401338. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 59-02-9, 68-26-8, 79-81-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - A liquid chromatographic method is described for the analysis of all-rac-α-tocopheryl acetate, tocopherols and retinyl palmitate in the infant formula standard reference material 1846. The vitamins were extracted in isopropanol and hexane/ethyl acetate without saponification and quantitated by normal phase chromatography with fluorescence detection. Retinyl palmitate, all-rac-α-tocopheryl acetate and naturally occurring tocopherols were quantitated isocratically with a mobile phase of 0.5% isopropanol in hexane. The results were within the certified ranges for all-rac-α-tocopheryl acetate and retinyl palmitate. Recoveries averaged 97.5% for retinyl palmitate and 101% for all-rac-α-tocopheryl acetate (n = 20).
KW - alpha-tocopherol
KW - analytical methods
KW - composition
KW - fluorescence
KW - infant formulae
KW - liquid chromatography
KW - milk products
KW - retinol
KW - retinyl palmitate
KW - tocopherols
KW - vitamins
KW - all-rac-alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - dairy products
KW - infant formula
KW - infant formulas
KW - retinol palmitate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Environmental assessments for animal drug products.
AU - Miller, M. A.
AU - Eirkson, C. E.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 1997///
VL - 20
SP - 323
EP - 325
SN - 0140-7783
AD - Miller, M. A.: III, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, US Food and Drug Administraton, Rockville, MD 20855, USA.
N1 - Accession Number: 19982200121. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Veterinary Science
KW - drugs
KW - environmental assessment
KW - legislation
KW - nontarget effects
KW - pharmacology
KW - public health
KW - veterinary products
KW - European Union
KW - USA
KW - Europe
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - Common Market
KW - EC
KW - EEC
KW - European Communities
KW - European Economic Communities
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982200121&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A retrospective analysis of drug residues in food producing animals in the USA for 1993, 1994, and 1995.
AU - Paige, J. C.
AU - Peli, F.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 1997///
VL - 20
SP - 328
EP - 328
SN - 0140-7783
AD - Paige, J. C.: US Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19982200124. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Veterinary Science
KW - antibacterial agents
KW - antibiotics
KW - antiinfective agents
KW - drug residues
KW - drugs
KW - food hygiene
KW - livestock
KW - meat hygiene
KW - pharmacology
KW - USA
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antimicrobials
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982200124&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemic dengue/dengue haemorrhagic fever: a global public health problem in the 21st century.
AU - Gubler, D. J.
JO - Dengue Bulletin
JF - Dengue Bulletin
Y1 - 1997///
VL - 21
SP - 1
EP - 15
AD - Gubler, D. J.: Division of Vector-Bome Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20000508446. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - This paper briefly reviews the changing epidemiology of dengue, discusses some of the factors responsible for the recent resurgence, and reviews the current options available for reversing the emerging trend of the disease.
KW - arboviruses
KW - dengue
KW - dengue haemorrhagic fever
KW - epidemiology
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - dengue hemorrhagic fever
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000508446&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use and effectiveness of condoms during anal intercourse: a review.
AU - Silverman, B. G.
AU - Gross, T. P.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 1997///
VL - 24
IS - 1
SP - 11
EP - 17
SN - 0148-5717
AD - Silverman, B. G.: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20850, USA.
N1 - Accession Number: 19972002423. Publication Type: Journal Article. Language: English. Number of References: 37 ref.
N2 - Development of newer and more effective condoms for use during anal intercourse requires consideration of the ethical issues involved in testing and marketing devices used during an activity that carries with it the potential for a substantial risk to health.
KW - anal intercourse
KW - behaviour
KW - condoms
KW - ethics
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - risk behaviour
KW - sexual behaviour
KW - transmission
KW - Human immunodeficiency virus 1
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - risk behavior
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972002423&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Potential contribution to high first-pass metabolism.
AU - Fitzsimmons, M. E.
AU - Collins, J. M.
JO - Drug Metabolism and Disposition
JF - Drug Metabolism and Disposition
Y1 - 1997///
VL - 25
IS - 2
SP - 256
EP - 266
SN - 0090-9556
AD - Fitzsimmons, M. E.: U.S. Food and Drug Administration, Division of Clinical Pharmacology Research, 4 Research Court, Room 11, Rockville, MD 20850, USA.
N1 - Accession Number: 19972003817. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9035-51-2, 127779-20-8.
N2 - The objectives of the present research were to determine the potential of human hepatic and small-intestinal microsomes to metabolize saquinavir, to identify the enzyme systems involved in its biotransformation, and to assess in vitro potential metabolic interactions. The results presented herein show that saquinavir is oxidized by both human hepatic and small-intestinal microsomes to multiple metabolites, that CYP3A4 is the predominant enzyme involved in its biotransformation, and that drug interactions of saquinavir with indinavir or terfenadine at the level of the small intestine may be significant. Based on the present data, the high rate of intestinal oxidation demonstrated in vitro suggests that the small intestine may play a critical role in the extensive first-pass metabolism of saquinavir and, therefore, in its low relative bioavailability. Combination therapy with saquinavir and indinavir may attenuate the high first-pass effect, increase its oral bioavailability, and result in greater efficacy of HIV protease inhibition.
KW - antiviral agents
KW - combination therapy
KW - cytochrome p-450
KW - drugs
KW - HIV infections
KW - human immunodeficiency viruses
KW - in vitro
KW - interactions
KW - intestines
KW - metabolism
KW - proteinase inhibitors
KW - proteinases
KW - saquinavir
KW - treatment
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - combined modality therapy
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - medicines
KW - multimodal treatment
KW - pharmaceuticals
KW - protease inhibitors
KW - proteases
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003817&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusion.
AU - Patterson, T. A.
AU - Binienda, Z. K.
AU - Lipe, G. W.
AU - Gillam, M. P.
AU - Slikker, W. Jr.
AU - Sandberg, J. A.
JO - Drug Metabolism and Disposition
JF - Drug Metabolism and Disposition
Y1 - 1997///
VL - 25
IS - 4
SP - 453
EP - 459
SN - 0090-9556
AD - Patterson, T. A.: Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19972004587. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 30516-87-1.
N2 - The intravenous kinetics of AZT in Macaca mulatta are similar to those reported for humans and other nonhuman primates. AZT, when administered intravenously was rapidly converted to its major metabolite, the glucuronide AZTG. When infused intravenously over a 3-h period, AZT readily crossed the placenta and was found in fetal plasma, and in all fetal tissues examined as either parent compound, the glucuronide, or monophosphate metabolite. The AZT fetal-to-maternal plasma concentration ratio of 0.85 suggests that AZT does not accumulate in the fetus. In placenta and spleen, AZT-MP concentrations equalled or exceeded AZTG concentrations. Although fetal plasma AZT concentrations obtained in the present study were similar to peak plasma AZT concentrations observed clinically, the putative active antiviral metabolite, AZT-TP, was not detected in any monkey fetal tissue. However, based on the amount of the monophosphorylated metabolite observed in some tissues, clinically relevant concentrations of the triphosphate metabolite may still have been present.
KW - antiviral agents
KW - concentration
KW - drug therapy
KW - fetus
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - maternal transmission
KW - metabolism
KW - metabolites
KW - pharmacokinetics
KW - placenta
KW - treatment
KW - zidovudine
KW - Macaca
KW - Macaca mulatta
KW - man
KW - monkeys
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Macaca
KW - Homo
KW - Hominidae
KW - AZT
KW - chemotherapy
KW - foetus
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mother to child transmission
KW - Pesticides and Drugs (General) (HH400)
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972004587&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of pertussis in U.S. marine corps trainees.
AU - Jansen, D. L.
AU - Gray, G. C.
AU - Putnam, S. D.
AU - Lynn, F.
AU - Meade, B. D.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1997///
VL - 25
IS - 5
SP - 1099
EP - 1107
SN - 1058-4838
AD - Jansen, D. L.: US Food and Drug Administration, Rockville, Maryland 20852, USA.
N1 - Accession Number: 19982003773. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - One hundred twenty male US Marine Corps trainees with histories of at least 7 days of cough underwent evaluation for Bordetella pertussis infection by culture, B. pertussis-specific polymerase chain reaction (PCR) analysis, and serology. Antibody levels in preexposure, acute-phase, and convalescent-phase serum samples were measured in a microagglutination assay and in enzyme linked immunosorbent assays (ELISAs) for IgG and IgA antibodies to pertussis toxin, filamentous haemagglutinin, pertactin, and fimbriae types 2 and 3. Culture and PCR analysis revealed that none of the patients was positive for B. pertussis; however, 20 of 120 trainees had serological evidence of B. pertussis infection. Of these cases, one was confirmed by a rise in the level of antibody to pertussis toxin, and 6 were classified as probable by increases in levels of antibodies measured by 2 or more assays. Of the 20 individuals with serological evidence of infection, 16 had rises in levels of antibodies to fimbriae or agglutinating antibodies. The utility of ELISA for detecting antibodies to fimbriae and the microagglutination assay for diagnosing pertussis in adults should be evaluated by application to larger and more diverse study populations. These results indicate that pertussis should be considered in the diagnosis of coughing illness in military populations.
KW - analysis
KW - antibodies
KW - diagnosis
KW - ELISA
KW - evaluation
KW - fimbriae
KW - human diseases
KW - males
KW - military personnel
KW - patients
KW - pertussis
KW - polymerase chain reaction
KW - serology
KW - USA
KW - Bordetella pertussis
KW - man
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - PCR
KW - United States of America
KW - whooping cough
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003773&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intake of nutrients related to cardiovascular disease risk among three groups of American Indians: the Strong Heart Dietary Study.
AU - Zephier, E. M.
AU - Ballew, C.
AU - Mokdad, A.
AU - Mendlein, J.
AU - Smith, C.
AU - Yeh, J. L.
AU - Lee, E.
AU - Welty, T. K.
AU - Howard, B.
JO - Preventive Medicine
JF - Preventive Medicine
Y1 - 1997///
VL - 26
IS - 4
SP - 508
EP - 515
SN - 0091-7435
AD - Zephier, E. M.: Indian Health Service, Aberdeen Area Office, 115 4th Avenue SE, Aberdeen, South Dakota 57401, USA.
N1 - Accession Number: 19981407370. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - The Strong Heart Dietary Study (SHDS) compared the diets of tribes from central Arizona, Oklahoma and North and South Dakota during 1988-91. A total of 892 people, 45- to 74-years-old, responded to the 24-h diet recall questionnaire. Men consumed more energy, macronutrients and Na, than women. Women consumed diets that were denser in carbohydrates, β-carotene, vitamin C and E. Younger participants consumed more energy and macronutrients compared with older participants, and more vitamin E and Na. Older people consumed more protein, and more β-carotene. Men in the SHDS reported 300-400 fewer calories, 15-20 g less protein, fewer grams of total fat, more cholesterol and less Na than men in phase 1 of National Health and Nutrition Survey (NHANES III). Women in Oklahoma consumed less energy, protein and carbohydrate than women in NHANES III, whereas women in Arizona, and North and South Dakota had more energy from saturated fat and more cholesterol. Only half the participants in the SHDS dietary survey met the guidelines (\lees than\30% total fat intake and <10% saturated fat intake of total energy, cholesterol intake <300 mg/day, Na intake <2400 mg/day and fibre intake\greater than\20 g/day) for reduction of risk of chronic heart disease.
KW - age
KW - American indians
KW - antioxidants
KW - carbohydrates
KW - cardiovascular diseases
KW - cholesterol
KW - diet
KW - energy
KW - ethnic groups
KW - fats
KW - fibre
KW - food intake
KW - heart diseases
KW - intake
KW - minerals
KW - monoenoic fatty acids
KW - nutrients
KW - polyenoic fatty acids
KW - saturated fats
KW - sex
KW - trace elements
KW - tribal society
KW - vitamins
KW - Arizona
KW - North Dakota
KW - Oklahoma
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Great Plains States of USA
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - coronary diseases
KW - fiber
KW - microelements
KW - monounsaturated fatty acids
KW - polyunsaturated fatty acids
KW - saccharides
KW - United States of America
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981407370&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunodiagnosis of schistosomiasis.
AU - Tsang, V. C. W.
AU - Wilkins, P. P.
JO - Immunological Investigations
JF - Immunological Investigations
Y1 - 1997///
VL - 26
IS - 1/2
SP - 175
EP - 188
SN - 0882-0139
AD - Tsang, V. C. W.: Immunology Branch, Parasitic Diseases Division, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19980803320. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Helminthology
N2 - Immunodiagnostic techniques for human schistosomiasis are reviewed, with reference to ELISA and Western blotting. Their sensitivity and specificity are discussed. Antibody assays are particularly useful in the diagnosis of schistosomiasis in visitors from developed countries to endemic areas. These patients are often lightly infected and other diagnostic methods may fail to identify these infections. Initial screening may be performed in the field or laboratory with the FAST-ELISA, using adult microsomal antigens. Species-specific confirmation is obtained by immunoblotting with the same antigens.
KW - antibodies
KW - diagnosis
KW - diagnostic techniques
KW - ELISA
KW - helminths
KW - human diseases
KW - immunoblotting
KW - immunodiagnosis
KW - parasites
KW - reviews
KW - schistosomiasis
KW - screening
KW - Western blotting
KW - man
KW - Schistosoma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - enzyme linked immunosorbent assay
KW - parasitic worms
KW - schistosomosis
KW - screening tests
KW - serological diagnosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803320&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modulation of antioxidant enzymes in bleomycin-treated rats by vitamin C and β-carotene.
AU - Desai, V. G.
AU - Lyn-Cook, L. E.
AU - Anane Aidoo
AU - Casciano, D. A.
AU - Feuers, R. J.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1997///
VL - 29
IS - 2
SP - 127
EP - 132
CY - Mahwah; USA
PB - Lawrence Erlbaum Associates Inc.
SN - 0163-5581
AD - Desai, V. G.: Division of Genetic Toxicology, National Center for Toxicological Research, Food and Drug Administration, US Department of Health and Human Services, Jefferson, AR 72079, USA.
N1 - Accession Number: 20003007155. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 50-81-7, 7235-40-7, 9013-66-5. Subject Subsets: Human Nutrition
N2 - Bleomycin (BLM), an antineoplastic drug, is known to induce DNA strand breaks and is also mutagenic in mammalian cells; however, its mechanism of action is not well understood. It has been proposed that BLM cytotoxicity is mediated through the generation of reactive oxygen species. We have determined the effects of BLM on endogenous hepatic antioxidant enzymes such as glutathione peroxidase (GPx), glutathione reductase, and glucose-6-phosphate dehydrogenase in rats exposed to BLM in conjunction with dietary vitamins, vitamin C and β-carotene (BC). Male Fischer 344 rats of two different age groups were treated with BLM in the presence or absence of antioxidant vitamins. In control animals, an age-associated decrease in GPx activity was noted (p<0.05). The decrease in GPx activity observed in BLM-treated old animals given vitamin C was significant (p<0.05) compared with BLM-treated young animals fed vitamin C. BC moderately induced GPx and glutathione reductase activities in old BLM-treated animals; however, the increase in GPx was statistically significant (p<0.05) only compared with old controls. A similar increase was noted in the activities of all the enzymes examined in young animals. Our results indicate that BLM exposure was accompanied by alterations in the activities of endogenous antioxidant enzymes, with a profound increase in activities occurring in old animals. In addition, the observed enzyme activities were modulated by antioxidant vitamin administration. The observation that both vitamins displayed differential effects on the enzyme activities also suggests that vitamin C and BC exert their effects by separate mechanisms.
KW - antineoplastic agents
KW - antioxidants
KW - ascorbic acid
KW - beta-carotene
KW - enzymes
KW - glutathione peroxidase
KW - mutagenesis
KW - mutagens
KW - vitamins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cytotoxic agents
KW - vitamin C
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003007155&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Necrotizing soft tissue infections reported with nonsteroidal antiinflammatory drugs.
AU - Kahn, L. H.
AU - Styrt, B. A.
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
Y1 - 1997///
VL - 31
IS - 9
SP - 1034
EP - 1039
SN - 1042-9611
AD - Kahn, L. H.: Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19982006621. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 69 ref.
N2 - A search of the US Food and Drug Administration's Spontaneous Reporting System (SRS) for necrotizing soft tissue infections reported in conjunction with the use of NSAIDs was conducted, to identify any common features. A computer search of NSAID listings in the adverse event database recovered reports with codes for selected infection and necrosis-related diagnostic categories. From review of individual reports classified under these codes, cases were selected if the terms "necrotizing fasciitis", "necrotic" or "gangrenous" appeared in the adverse drug reaction description. Demographic, drug use and disease course information were gathered. 33 cases were identified, of which 10 were fatal. Over 66% of the patients were aged <40 years. 30 (91%) patients had a possible portal of entry for infection. Most patients had received NSAIDs for acute conditions including varicella, trauma and postoperative or postpartum pain; 7 received an NSAID by intramuscular injection. Specific NSAIDs accounting for most reports were also among those likely to be most heavily used in the relevant populations. The total number of SRS cases did not suggest that necrotizing infection is frequent with NSAIDs or likely without other risk factors.
KW - antiinflammatory agents
KW - bacterial diseases
KW - databases
KW - diagnosis
KW - drugs
KW - fasciitis
KW - human diseases
KW - immunocompromised hosts
KW - information
KW - necrosis
KW - opportunistic infections
KW - predisposition
KW - risk factors
KW - tissues
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - data banks
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006621&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Agreement between company-recorded and self-reported estimates of duration and frequency of occupational fumigant exposure.
AU - Calvert, G. M.
AU - Mueller, C. A.
AU - O'Neill, V. L.
AU - Fajen, J. M.
AU - Briggle, T.
AU - Fleming, L. E.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1997///
VL - 32
IS - 4
SP - 364
EP - 368
SN - 0271-3586
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-21, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19981105009. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Agricultural Entomology; Medical & Veterinary Entomology
N2 - As part of a cross-sectional medical study of structural fumigation workers in Florida, self-reported work history information was collected on both the duration and frequency of exposure using an interviewer-administered questionnaire. All company records available on these workers were also collected. Only 15 of 81 structural fumigation companies identified by study participants as current or past structural fumigation employers had records suitable for comparison. These 15 companies employed 32 of the workers who participated in the cross-sectional medical study. The exposure information provided by the 32 workers was compared to information obtained from company records. By examining the agreement between these two data sources, potential limitations were identified in both the self-reported and company-recorded exposure data. By recognizing these limitations in the exposure data, the most appropriate exposure measures to be used in subsequent data analyses were identified. This exercise also demonstrated the difficulties in undertaking these exposure comparisons in an industry consisting of many small, independent companies. Similar difficulties with assessing exposures may be experienced by investigators studying other service industries consisting of many small, independent companies.
KW - agricultural entomology
KW - fumigation
KW - insect control
KW - nontarget effects
KW - pesticides
KW - poisoning
KW - questionnaires
KW - risk assessment
KW - Florida
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - toxicosis
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981105009&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational risk of Mycobacterium tuberculosis infection in hospital workers.
AU - Boudreau, A. Y.
AU - Baron, S. L.
AU - Steenland, N. K.
AU - Gilder, T. J. van
AU - Decker, J. A.
AU - Galson, S. K.
AU - Seitz, T.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1997///
VL - 32
IS - 5
SP - 528
EP - 534
SN - 0271-3586
AD - Boudreau, A. Y.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Denver, CO, USA.
N1 - Accession Number: 19982007817. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - A 4-year (January 1989-December 1992) retrospective cohort study was conducted among employees at a large metropolitan hospital in the USA, where a nosocomial outbreak of multidrug-resistant tuberculosis (TB) had occurred. The risk of tuberculin skin test (TST) conversion among employees who worked on wards where patients with culture-confirmed TB were cared for ("exposed") was compared with the risk among employees who worked on wards with no such patients ("unexposed"). Exposed employees had a higher 4-year risk of TST conversion (14.5%) than unexposed employees (1.4%) (adjusted relative risk 14.3; 95% confidence interval 5.1-35.2). Exposed employees had significantly higher risks of conversion than unexposed employees during 1989-91, but not for 1992. Among the exposed, ward clerks had a risk of conversion (15.6%) only slightly lower than nurses (18.2%). It is concluded that employees who worked in areas where patients with active M. tuberculosis infection were cared for, including workers who did not provide direct patient care, had a higher risk of TST conversion than employees who did not work in these areas. Reasons for the decline in risk over time include outbreak termination, fewer admissions of patients with TB, implementation of effective infection control measures, and possible resistance to infection in some members of the study population.
KW - bacterial diseases
KW - drug resistance
KW - epidemiology
KW - health care workers
KW - hospital personnel
KW - human diseases
KW - incidence
KW - multiple drug resistance
KW - mycobacterial diseases
KW - nosocomial infections
KW - outbreaks
KW - risk factors
KW - tuberculosis
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - hospital infections
KW - mycobacterial infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of HIV replication by immunoliposomal antisense oligonucleotide.
AU - Selvam, M. P.
AU - Buck, S. M.
AU - Blay, R. A.
AU - Mayner, R. E.
AU - Mied, P. A.
AU - Epstein, J. S.
JO - Antiviral Research
JF - Antiviral Research
Y1 - 1997///
VL - 33
IS - 1
SP - 11
EP - 20
SN - 0166-3542
AD - Selvam, M. P.: HFM-321, Center for Biologics, Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD-20852, USA.
N1 - Accession Number: 19972001492. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2, 9068-38-6.
N2 - The sequence-specific suppression of HIV-1 replication using CD4 monoclonal-antibody-targeted liposomes, containing Rev antisense phosphorothioate oligonucleotides is described. Liposomes were prepared by encapsulating the 20-mer antisense DNA sequence of the rev HIV-1 regulatory gene, in the form of a phosphorothioate oligonucleotide. HIV-1 replication was reduced by 85% in antisense immunoliposome-treated H9 cells and peripheral blood lymphocytes, whereas the inhibition of HIV-1 replication was not observed using either empty immunoliposomes or immunoliposomes containing scrambled Rev phosphorothioate oligonucleotide sequences. Liposome preparations demonstrated minimal toxicity in H9 as well as in peripheral blood lymphocyte cell culture experiments.
KW - antibodies
KW - antiviral agents
KW - CD4 antigens
KW - DNA
KW - human immunodeficiency viruses
KW - in vitro
KW - inhibition
KW - liposomes
KW - monoclonal antibodies
KW - nucleotide sequences
KW - polymerase chain reaction
KW - replication
KW - rev gene
KW - reverse transcriptase
KW - T lymphocytes
KW - toxicity
KW - treatment
KW - Human immunodeficiency virus 1
KW - mice
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-sense and mis-sense RNA
KW - antisense oligonucleotides
KW - CD4
KW - deoxyribonucleic acid
KW - DNA sequences
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - PCR
KW - T cells
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance and spatiotemporal associations of rabies in rodents and lagomorphs in the United States, 1985-1994.
AU - Childs, J. E.
AU - Colby, L.
AU - Krebs, J. W.
AU - Strine, T.
AU - Feller, M.
AU - Noah, D.
AU - Drenzek, C.
AU - Smith, J. S.
AU - Rupprecht, C. E.
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
Y1 - 1997///
VL - 33
IS - 1
SP - 20
EP - 27
SN - 0090-3558
AD - Childs, J. E.: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Road MS/G13, Atlanta GA, 30333, USA.
N1 - Accession Number: 19972204851. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Between 1985 and 1994, 368 cases of rabies in rodents (95% of reports) and lagomorphs (all rabbits; 5%) were reported to the Centers for Disease Control and Prevention, Atlanta, Georgia, from 22 states. This was a 354% increase from the period 1971 to 1984. Most reports were cases of rabies in woodchucks (Marmota monax) (n = 317), primarily from the eastern USA, which has been recently experienced an epidemic of raccoon (Procyon lotor) rabies. Cases of rabies in woodchucks were temporally and spatially associated with reports of raccoon rabies. Antigenic or genetic characterization of variants of rabies viruses from rodents and woodchucks corresponded to the variants associated with the major terrestrial wildlife reservoir within the geographic region of specimen origin. Although rodents and lagomorphs are infrequently infected with rabies and human contact with these animals rarely requires postexposure treatment, appropriate health authorities need to evaluate individual circumstances surrounding potential exposures.
KW - epidemiology
KW - rabies
KW - surveillance
KW - viral diseases
KW - wild animals
KW - USA
KW - lagomorpha
KW - marmota monax
KW - procyon lotor
KW - rabbits
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Marmota
KW - Sciuridae
KW - rodents
KW - Procyon
KW - Procyonidae
KW - Fissipeda
KW - carnivores
KW - Leporidae
KW - Lagomorpha
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of Ixodes scapularis, I. spinipalpis, and Dermacentor andersoni (Acari: Ixodidae) in transmitting Borrelia burgdorferi, the etiologic agent of Lyme disease.
AU - Dolan, M. C.
AU - Maupin, G. O.
AU - Panella, N. A.
AU - Golde, W. T.
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1997///
VL - 34
IS - 2
SP - 128
EP - 135
SN - 0022-2585
AD - Dolan, M. C.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970502146. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - This report describes the vector competence of I. scapularis, I. spinipalpis and D. andersoni for B. burgdorferi in Colorado, USA. The study was based on preliminary field work performed in 1994 in 6 Colorado counties, where rodents and ticks were collected and assayed for the presence of B. burgdorferi. Four of the 6 counties produced 52 rodent and 39 I. spinipalpis isolates of B. burgdorferi. Two B. burgdorferi isolates were tested under laboratory conditions and found to be infective to ICRF outbred mice. The 1st, a low-passage strain originating from New York (B-31, passage 6) was used as a control, and the 2nd was isolated from ear tissue of a wood rat (Neotoma mexicana) that was trapped in Colorado. Larvae of I. scapularis, I. spinipalpis and D. andersoni were fed on infected mice and cultured in Barbour-Stoner-Kelly media to assay for infection at 1, 2, 3 and 4 weeks after repletion. The infection rates in replete larvae were 75, 69 and 8.5%, respectively, whereas transstadial nymphal infection rates were 80, 75 and 0%, respectively. Both I. scapularis and I. spinipalpis were shown to be competent vectors that acquired the infection from the host reservoir mice and subsequently transmitted it to naive mice. Given that I. scapularis are not found in Colorado, I. spinipalpis are restricted to the nests and burrows of rodents, and because of the semiarid environment in Colorado, the risk of human contact with B. burgdorferi appears to be low.
KW - disease vectors
KW - ectoparasites
KW - epidemiology
KW - laboratory animals
KW - Lyme disease
KW - reservoir hosts
KW - small mammals
KW - vector competence
KW - wild animals
KW - zoonoses
KW - Colorado
KW - North America
KW - USA
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Dermacentor andersoni
KW - Ixodes scapularis
KW - Ixodidae
KW - mice
KW - Neotoma
KW - Neotoma albigula
KW - Neotoma mexicana
KW - Peromyscus
KW - Peromyscus boylii
KW - Peromyscus maniculatus
KW - Peromyscus truei
KW - Reithrodontomys
KW - Reithrodontomys megalotis
KW - rodents
KW - Spermophilus
KW - Spermophilus variegatus
KW - Tamias
KW - Tamias quadrivittatus
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Sigmodontinae
KW - Neotoma
KW - Peromyscus
KW - Reithrodontomys
KW - Sciuridae
KW - Spermophilus
KW - Tamias
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - animal reservoirs
KW - bacterium
KW - Ixodes spinipalpis
KW - lyme borreliosis
KW - Sciurinae
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Susceptibility of immature Ixodes scapularis (Acari: Ixodidae) to plant-derived acaricides.
AU - Panella, N. A.
AU - Karchesy, J.
AU - Maupin, G. O.
AU - Malan, J. C. S.
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1997///
VL - 34
IS - 3
SP - 340
EP - 345
SN - 0022-2585
AD - Panella, N. A.: Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970502654. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Botanical Pesticides; Horticultural Science; Medical & Veterinary Entomology
N2 - Plant-derived acaricides, extracted from various botanical species, and commercially available phytochemicals were evaluated for biological activity against immature I. scapularis ticks using the disposable pipette method. In addition, residual activity of the plant extracts was determined. Of the 13 plant extracts tested, 9 exhibited biological activity with Alaska yellow cedar (Chamaecyparis nootkatensis) being the most effective against the nymphal ticks (LC50 = 0.151% wt:vol) and eastern red cedar (Juniperus virginiana) showing the greatest activity against larval ticks (LC50 = 0.001% wt:vol). The commercially available products were significantly less active than the plant extracts prepared by the authors, but some commercial compounds did exhibit limited activity. Only the Alaska yellow cedar exhibited any residual activity that lasted 21 days after treatment.
KW - acaricidal plants
KW - acaricides
KW - botanical acaricides
KW - botanical insecticides
KW - ectoparasites
KW - extracts
KW - insecticidal plants
KW - insecticides
KW - larvae
KW - nymphs
KW - plant extracts
KW - susceptibility
KW - toxicity
KW - Acari
KW - Arachnida
KW - Ixodes scapularis
KW - Juniperus virginiana
KW - plants
KW - Xanthocyparis nootkatensis
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Juniperus
KW - Cupressaceae
KW - Pinopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - Xanthocyparis
KW - alpha-cedrene
KW - cedryl acetate
KW - Chamaecyparis nootkatensis
KW - nootka cypress
KW - terpinen-4-ol
KW - thujopsen
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Resources (Plant) (PP720)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Non-wood Forest Products (KK540)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ability of the Lyme disease spirochete Borrelia burgdorferi to infect rodents and three species of human-biting ticks (blacklegged tick, American dog tick, Lone Star tick) (Acari: Ixodidae).
AU - Piesman, J.
AU - Happ, C. M.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1997///
VL - 34
IS - 4
SP - 451
EP - 456
SN - 0022-2585
AD - Piesman, J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970503293. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The infectivity of a diverse collection of B. burgdorferi strains from North America for mice was determined as a prelude to vector competence experiments with the 3 primary human-biting tick species in the eastern USA (Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum). Of the 34 B. burgdorferi strains inoculated into mice, 29 were infectious; the exceptions were 5 isolates from Texas. Vector competence experiments were conducted with 2 strains from the southern USA (North Carolina and Georgia). Both strains were extremely infectious to I. scapularis larvae. Moreover, I. scapularis efficiently maintained these spirochaetes transstadially and transmitted infection as nymphs. D. variabilis larvae were intermediate in susceptibility but generally did not maintain the infection transstadially. A. americanum larvae were completely refractory to infection with these 2 southern B. burgdorferi strains. Three isolates from Michigan D. variabilis were inoculated into mice, and subsequently exposed to I. scapularis and D. variabilis larvae. Larval I. scapularis were 5-fold more susceptible to infection with these strains than were larval D. variabilis. Although nymphal I. scapularis efficiently transmitted a Michigan isolate, nymphal D. variabilis did not. In all these experiments, I. scapularis was the only species that proved to be vector competent for B. burgdorferi.
KW - disease transmission
KW - disease vectors
KW - infection
KW - infectivity
KW - laboratory animals
KW - Lyme disease
KW - vector competence
KW - California
KW - Colorado
KW - Georgia
KW - Illinois
KW - Michigan
KW - North Carolina
KW - Texas
KW - USA
KW - Wisconsin
KW - Acari
KW - Amblyomma americanum
KW - Arachnida
KW - Borrelia burgdorferi
KW - Dermacentor variabilis
KW - Ixodes scapularis
KW - Ixodidae
KW - mice
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Amblyomma
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Dermacentor
KW - Ixodes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Mountain States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Southeastern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - Appalachian States of USA
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southwestern States of USA
KW - bacterium
KW - lone star tick
KW - lyme borreliosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of polychlorinated dibenzo-p-dioxin and dibenzofuran background in milk and cheese by quadrupole ion storage collision induced dissociated MS/MS.
AU - Hayward, D. G.
A2 - Birnbaum, L.
A2 - Clement, R.
A2 - Fiedler, H.
A2 - Hutzinger, O.
A2 - Reiner, E.
A2 - Safe, S.
JO - Chemosphere
JF - Chemosphere
Y1 - 1997///
VL - 34
IS - 5/7
SP - 929
EP - 939
SN - 0045-6535
AD - Hayward, D. G.: Methods Research Branch, Division of Pesticides and Industrial Chemicals, US Food and Drug Administration, 200 C St SW, Washington DC 20204, USA.
N1 - Accession Number: 19970401942. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Samples of milk and cheese purchased from retail stores in Washington DC and Florida were analysed for bio-incurred or background contamination by all 17 of the 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). All test portions were fortified with 15 13C12-labelled congeners at 1 ng/kg wet weight (5 ng/kg for cheese). Duplicate test portions were fortified with 15 or 17 native congeners (all 2,3,7,8-substituted congeners except octachlorodibenzo-p-dioxin and octachlorodibenzofuran for milk analyses) at either 0.192 or 0.96 ng/kg wet weight for milk (cheese was fortified at 1.0 ng/kg with all 17 congeners). 200-g samples of milk and 50-g samples of cheese were analysed. Analytes were measured by both full-scan electron impact low-resolution mass spectrometry (EI-LRMS) and collision-induced dissociation MS/MS (CID MS/MS). Results were comparable using either technique. CID MS/MS, however, provided higher sensitivity and selectivity on many congeners. The results for CID MS/MS were reproducible, with little reduction in sensitivity or spectral quality during the analyses of all test samples. The CID MS/MS signal:noise ratio (S:N) was 10 to 100 times greater than EI-LRMS performed with the same instrument in food matrices. S:N increased on most parent ions as well as for all daughter ions. It is concluded that further development of this technique may provide a cost-effective alternative to traditional high-resolution MS analyses of PCDDs and PCDFs in food.
KW - analytical methods
KW - cheeses
KW - congeners
KW - food contamination
KW - mass spectrometry
KW - milk
KW - milk products
KW - polychlorinated dibenzodioxins
KW - polychlorinated dibenzofurans
KW - District of Columbia
KW - Florida
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southeastern States of USA
KW - analytical techniques
KW - dairy products
KW - food contaminants
KW - octachlorodibenzo-p-dioxin
KW - octachlorodibenzofuran
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pollution and Degradation (PP600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biochemical and physiological characteristics of HlyA, a pore-forming cytolysin of Vibrio cholerae serogroup O1.
AU - Venugopal Sathyamoorthy
AU - Huntley, J. S.
AU - Hall, A. C.
AU - Hall, R. H.
JO - Toxicon (Oxford)
JF - Toxicon (Oxford)
Y1 - 1997///
VL - 35
IS - 4
SP - 515
EP - 527
SN - 0041-0101
AD - Venugopal Sathyamoorthy: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 19982005226. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Tropical Diseases
N2 - A single form of the cytolytic protein HlyA (El Tor haemolysis) from V. cholerae serogroup O1 was purified by gel filtration and chromatofocusing using fast protein liquid chromatography in the presence of protease inhibitors. A 45-fold purification was obtained, with a final recovery of 17% pure 60 000 MW HlyA. A significant improvement in specific activity to 8.5 × 106 Chinese hamster ovary tissue culture units per mg protein was obtained. Physiological activity studies indicated that cytolysis of erythrocytes (haemolysis) was inhibited by oxygen; storage of HlyA under oil, and experimentation in N2-flushed buffers maintained activity. HlyA-mediated lysis of human erythrocytes was characterized by a significant lag phase, followed by a rapid induction of haemolysis. Haemolysis was inhibited by sucrose, an osmotic protectant, suggesting that the initial action of HlyA on erythrocytes is to raise the basal cation permeability of the cell membrane. It is concluded that the most likely cytolytic mechanism is the formation of transmembrane lesions such as homopolymer pores in target cells, as has been found for toxins from numerous other bacterial pathogens.
KW - bacterial diseases
KW - bacterial toxins
KW - cholera
KW - cytolysis
KW - haemolysis
KW - human diseases
KW - toxicity
KW - Vibrio cholerae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - hemolysis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005226&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Colorado tick fever virus by using reverse transcriptase PCR and application of the technique in laboratory diagnosis.
AU - Johnson, A. J.
AU - Karabatsos, N.
AU - Lanciotti, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1997///
VL - 35
IS - 5
SP - 1203
EP - 1208
SN - 0095-1137
AD - Johnson, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970504330. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9068-38-6. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Colorado tick fever (CTF) virus elicits an acute illness in humans, producing nonspecific flu-like symptoms and a biphasic fever in ~50% of patients. The early symptoms of infection are difficult to distinguish from those of several other agents, especially Rickettsia rickettsii. Serological testing is usually unable to provide evidence of CTF viral infection during the acute phase because of the late appearance of the various antibodies. The authors report the development and clinical application of a test to diagnose this disease during the acute stages. Oligonucleotide primers to the S2 segment of CTF (Florio) virus were made, and these were used in the amplification of a 528-bp fragment of DNA, transcribed from the double-stranded CTF virus RNA template by reverse transcriptase PCR. RNAs processed from 16 CTF virus isolates yielded similar results when analysed on agarose gels. These were distinguishable from their antigenic relatives Eyach, S6-14-03 and T5-2092 and from other coltiviruses and an orbivirus but not from the antigenically distinct CTF virus-related isolate 720896. A mouse model demonstrated the utility of this method with whole-blood specimens, and CTF virus was successfully detected in human sera from the initial day of the onset of symptoms to 8 days later. The reverse transcriptase PCR method is a promising tool for the early diagnosis of CTF viral infection, or for ruling out CTF virus as the aetiological agent.
KW - arboviruses
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - laboratory animals
KW - laboratory diagnosis
KW - polymerase chain reaction
KW - reverse transcriptase
KW - Colorado
KW - USA
KW - Colorado tick fever virus
KW - man
KW - mice
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - arthropod-borne viruses
KW - Colorado tick fever
KW - PCR
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504330&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monoclonal antibodies capable of distinguishing epizootic from enzootic varieties of subtype 1 Venezuelan equine encephalitis viruses in a rapid indirect immunofluorescence assay.
AU - Roehrig, J. T.
AU - Bolin, R. A.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1997///
VL - 35
IS - 7
SP - 1887
EP - 1890
SN - 0095-1137
AD - Roehrig, J. T.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502301. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The authors used previously characterized murine monoclonal antibodies to develop a panel useful in subtyping Venezuelan equine encephalitis (VEE) viruses by an indirect fluorescent antibody assay. This panel worked well with either prototype VEE viruses or a series of more recent VEE virus isolates. The panel is particularly useful for rapidly differentiating VEE viruses with epidemic-epizootic potential from other endemic varieties of this virus. Using this panel, the authors identified an antigenic variant of prototype VEE subtype 1E virus currently present in Mexico. This antigenic change in the E2 glycoprotein was confirmed by ELISA. Because VEE virus virulence has been associated in part with the E2 glycoprotein, this observed antigenic change in the 1E virus E2 glycoprotein may explain the apparent equine virulence of this unusual VEE 1E virus.
KW - antigens
KW - arboviruses
KW - diagnosis
KW - envelope proteins
KW - glycoproteins
KW - immunofluorescence
KW - monoclonal antibodies
KW - viral proteins
KW - virulence
KW - zoonoses
KW - Colombia
KW - Ecuador
KW - Mexico
KW - Panama
KW - Peru
KW - USA
KW - Venezuela
KW - horses
KW - man
KW - Venezuelan equine encephalitis virus
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - APEC countries
KW - North America
KW - OECD Countries
KW - Central America
KW - Developed Countries
KW - antigenicity
KW - arthropod-borne viruses
KW - fluorescent antibody technique
KW - IFAT
KW - immunogens
KW - United States of America
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502301&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of a nested, multiplex PCR to psittacosis outbreaks.
AU - Messmer, T. O.
AU - Skelton, S. K.
AU - Moroney, J. F.
AU - Daugharty, H.
AU - Fields, B. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1997///
VL - 35
IS - 8
SP - 2043
EP - 2046
SN - 0095-1137
AD - Messmer, T. O.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19982005370. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - A nested, multiplex PCR was developed for the simultaneous detection of 3 species of chlamydiae in human and avian specimens. The PCR was designed to increase sensitivity and to circumvent inhibitors of PCR present in clinical specimens. The target sequence was the 16S rRNA gene. The first-step PCR was genus specific, and the second-step PCR was multiplexed (i.e., had multiple primer sets in the same tube) and could discriminate among Chlamydia pneumoniae, C. psittaci, and C. trachomatis on the basis of the molecular weight of the amplicon. The limit of detection of each of the 2 PCR steps was 5 inclusion-forming units. Along with serological evidence, the PCR technique was used to confirm that C. psittaci had been transmitted from birds purchased in pet stores in West Virginia to humans who were experiencing a psittacosis-like illness. Compared with culture, the application of PCR to avian specimens increased the rate of C. psittaci detection.
KW - animal diseases
KW - detection
KW - diagnosis
KW - human diseases
KW - outbreaks
KW - polymerase chain reaction
KW - psittacosis
KW - serology
KW - USA
KW - West Virginia
KW - birds
KW - Chlamydia trachomatis
KW - Chlamydophila pneumoniae
KW - Chlamydophila psittaci
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - Chlamydophila
KW - bacterium
KW - Chlamydia pneumoniae
KW - Chlamydia psittaci
KW - ornithosis
KW - PCR
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005370&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Testing the potential of sodium fluoride to affect spermatogenesis in the rat.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Rorie, J.
AU - Ames, M. J.
AU - O'Donnell, M.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1997///
VL - 35
IS - 9
SP - 881
EP - 890
SN - 0278-6915
AD - Sprando, R. L.: Division of Toxicological Research, Center for Food Safety Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Beltsville, MD 20708, USA.
N1 - Accession Number: 19981402655. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Registry Number: 16984-48-8, 7681-49-4, 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8, 15262-86-9. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - Male and female rats (P generation) were assigned by weight to a control group (NaF <0.2 mg/kg) or one of 4 treatment groups containing NaF 25, 100, 175 or 250 mg/kg in their drinking water for 10 weeks. Males were then mated to females within the same treatment groups. Reproductive tissues were collected from P generation male rats after 14 weeks of treatment. Pregnant females (P) were then exposed to NaF via drinking water through gestation and lactation. F1 generation weanling male rats remained within the same treatment groups as their parents. F1 generation male rats were exposed to NaF in drinking water for 14 weeks, at which time reproductive tissues were collected. Dose-related effects were not observed within the P and F1 treatment groups with respect to weights of testes, prostate/seminal vesicle and non-reproductive organs, testicular spermatid counts, daily sperm production/g testis, sperm production/g testis, LH, FSH or serum testosterone concentrations. Histological changes were not observed in testicular tissues from the P or F1 generations. It is concluded that prolonged exposure to NaF in drinking water at the doses administered in this study does not adversely affect spermatogenesis or endocrine function in the P and F1 generation male rats.
KW - drinking water
KW - endocrinology
KW - fluoride
KW - males
KW - reproductive organs
KW - sex hormones
KW - sodium fluoride
KW - spermatogenesis
KW - spermatozoa
KW - testes
KW - testosterone
KW - toxicology
KW - trace elements
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - microelements
KW - sperm
KW - testicles
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402655&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenicity of azo dyes used in foods, drugs and cosmetics before and after reduction by Clostridium species from the human intestinal tract.
AU - Rafii, F.
AU - Hall, J. D.
AU - Cerniglia, C. E.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1997///
VL - 35
IS - 9
SP - 897
EP - 901
SN - 0278-6915
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981402653. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - Various azo dyes currently used in foods, drugs and cosmetics are reduced by anaerobic bacteria from the human intestinal tract. These bacteria with azo reductase activities include several Clostridium species. Seven of these azo dyes (0.5 or 2.0 mg) and their reduction products following incubation with a Clostridium sp. were evaluated for mutagenicity in Salmonella typhimurium strains TA98 and TA100 using the plate incorporation assay. No mutagenicity was induced in TA98 or TA100 by any of the 7 azo dyes or the reduced metabolites when tested at concentrations as high as 200 µg/plate, with or without exogenous metabolic activation by rat liver fraction S-9.
KW - dyes
KW - food additives
KW - foods
KW - in vitro
KW - intestinal microorganisms
KW - mutagenicity
KW - Clostridium
KW - man
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - dyestuffs
KW - gut flora
KW - intestinal micro-organisms
KW - Food Additives (QQ130)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402653&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of the embryotoxic potential of the total hydrolysis product of fumonisin B1 using cultured organogenesis-staged rat embryos.
AU - Flynn, T. J.
AU - Stack, M. E.
AU - Troy, A. L.
AU - Chirtel, S. J.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 1997///
VL - 35
IS - 12
SP - 1135
EP - 1141
SN - 0278-6915
AD - Flynn, T. J.: Division of Toxicological Research, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19981200524. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The embryotoxicity of aminopentol (API), the total hydrolysis product of fumonisin B1 (FB1), was evaluated in cultured rat embryos. Gestation day 9.5 embryos were exposed to 0, 3, 10, 30, 100 or 300 µM API throughout the entire 45-h culture period. At 100 µM API, growth and overall development were reduced significantly. There was also a significant increase in the incidence of abnormal embryos. 29% of the embryos had neural tube defects (NTD) and 36% of the embryos had other abnormalities. At 300 µM API, the incidence of NTD was 15% and 85% of the embryos had other abnormalities. It is suggested that API, at concentrations of 100 µM and above, can induce NTD in organogenesis-stage cultured rat embryos. However, these NTD are in conjunction with significant overall retardation of growth and development as well as significant increases in the incidence of other defects. These results also showed that, in comparison with previous findings, API is >100-fold less toxic than FB1 to cultured rat embryos.
KW - embryos
KW - fumonisins
KW - mycotoxins
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981200524&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food and Drug Administration Conference on the feasibility of genetic technology to close the HIV window in donor screening.
AU - Hewlett, I. K.
AU - Epstein, J. S.
JO - Transfusion
JF - Transfusion
Y1 - 1997///
VL - 37
IS - 3
SP - 346
EP - 351
SN - 0041-1132
AD - Hewlett, I. K.: Laboratory of Molecular Virology, Division of Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-315, 1401 Rockville Pike, Suite 300N, Rockville, ND 20852-1448, USA.
N1 - Accession Number: 19972003807. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref.
N2 - A panel of experts held a roundtable discussion on future directions. There was general agreement that, given the current risk estimates (which have been reduced even further than estimated in 1994) and the stage of development of gene-based technology at the time, costs for implementation such technology in donor screening would be enormous. It was felt that focused effort was needed in several technical areas, such as sample preparation, containment to reduce contamination, high throughput, and automation, to make this technology more suitable and user-friendly for mass screening. However, there seemed to be more immediate applications for the technology: (1) early virus detection in newborns, (2) monitoring patients on antiviral therapy, (3) prognostic indicator for disease progression, and (4) confirmatory assay in cases of indeterminate serology. Finally interest was expressed by several individuals in forming a working group involving experts from various public health agencies and industry to develop standards for validation of nucleic acid assays for various applications relating to HIV.
KW - antiviral agents
KW - confirmatory tests
KW - detection
KW - epidemiology
KW - feasibility studies
KW - human immunodeficiency viruses
KW - industry
KW - monitoring
KW - nucleic acids
KW - patients
KW - public health
KW - surveillance
KW - technology
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - feasibility
KW - human immunodeficiency virus
KW - surveillance systems
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003807&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health impact on drug residues in animal tissues.
AU - Paige, J. C.
AU - Tollefson, L.
AU - Miller, M.
JO - Veterinary and Human Toxicology
JF - Veterinary and Human Toxicology
Y1 - 1997///
VL - 39
IS - 3
SP - 162
EP - 169
SN - 0145-6296
AD - Paige, J. C.: Division of Epidemiology and Surveillance, Food and Drug Administration/Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19972210336. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Veterinary Science; Human Nutrition; Public Health
N2 - This paper describes evidence for specific health hazards for certain classes of drugs and explains the risks associated with drug residues in meat. The focus is on the possible public health consequences that may occur as a result of acute exposure to illegal residues.
KW - drug residues
KW - food safety
KW - meat
KW - public health
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972210336&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of embryotoxicity of fumonisin B1 in New Zealand white rabbits.
AU - LaBorde, J. B.
AU - Terry, K. K.
AU - Howard, P. C.
AU - Chen, J. J.
AU - Collins, T. F. X.
AU - Shackelford, M. E.
AU - Hansen, D. K.
JO - Fundamental and Applied Toxicology
JF - Fundamental and Applied Toxicology
Y1 - 1997///
VL - 40
IS - 1
SP - 120
EP - 128
SN - 0272-0590
AD - LaBorde, J. B.: Department of Health and Human Services, Divison of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19981201925. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The embryotoxicity of fumonisin B1 (FB1) was investigated in new Zealand White rabbits, that were gavaged daily with purified FB1 at 0.10, 0.50 or 1.00 mg/kg from gestation days (GD) 3-19. Maternal lethality occurred at the 0.50 and 1.00 mg/kg daily doses. Examination on GD29 revealed no differences in maternal body weight, maternal weight gain, maternal organ weights, number of non-live implantations and number of malformations. For both male and female pups, fetal weight was decreased at 0.50 and 1.00 mg/kg daily FB1 (13 and 16%, respectively); fetal liver and kidney weights were also decreased at these doses. There were no differences between embryonic sphinganine to sphingosine ratios on GD20, although theses ratios were increased in maternal urine, serum and kidney compared with control animals. It is concluded that FB1 did not cross the placenta, and that the observed decreased fetal weight was probably the result of maternal toxicity rather than developmental toxicity due to FB1.
KW - embryos
KW - fumonisins
KW - mycotoxicoses
KW - mycotoxins
KW - poisoning
KW - toxicity
KW - rabbits
KW - Leporidae
KW - Lagomorpha
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - mycotoxin poisoning
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201925&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolism of rifabutin and its 25-desacetyl metabolite, LM565, by human liver microsomes and recombinant human cytochrome P-450 3A4: relevance to clinical interaction with fluconazole.
AU - Trapnell, C. B.
AU - Jamis-Dow, C.
AU - Klecker, R. W.
AU - Collins, J. M.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 1997///
VL - 41
IS - 5
SP - 924
EP - 926
SN - 0066-4804
AD - Trapnell, C. B.: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19971201227. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9035-51-2, 86386-73-4, 72559-06-9. Subject Subsets: Medical & Veterinary Mycology
N2 - This study aimed to determine if an observed rifabutin-fluconazole interaction was due to an inhibition of human hepatic enzymes. The metabolism of both rifabutin and LM565 was evaluated in human liver microsomes and recombinant human cytochrome P-450 (CYP) 3A4 in the presence of fluconazole and other probe drugs known to inhibit CYP groups 1A2, 2C9, 2D6, 2E1 and 3A. The concentrations of rifabutin (1 µg/ml), LM565 (1 µg/ml) and fluconazole (10 and 100 µg/ml) used were equal to those observed in plasma after the administration of rifabutin and fluconazole at clinically relevant doses. HPLC was used to assess the metabolism of rifabutin and LM565. Rifabutin was readily metabolized to LM565 by human microsomes, but the reaction was independent of NADPH and was not affected by the P-450 inhibitors. No rifabutin metabolism by recombinant CYP 3A4 occurred. LM565 was also metabolized by human microsomes to 2 products, but metabolism was dependent on NADPH and was affected by certain P-450 inhibitors. In addition, LM565 was readily metabolized by the recombinant CYP 3A4 to the same 2 products found with its metabolism by human microsomes. It is concluded that rifabutin is metabolized by human microsomes but not via cytochrome P-450 enzymes, whereas LM565 is metabolized by CYP 3A4.
KW - antagonism
KW - antifungal agents
KW - antimycobacterial agents
KW - combination therapy
KW - cytochrome p-450
KW - drug therapy
KW - fluconazole
KW - fungicides
KW - liver
KW - metabolism
KW - microsomes
KW - pharmacokinetics
KW - rifabutin
KW - chemotherapy
KW - combined modality therapy
KW - fungistats
KW - multimodal treatment
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201227&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methods for the determination of arsenic, cadmium, copper, lead, and tin in sucrose, corn syrups, and high-fructose corn syrups by inductively coupled plasma atomic emission spectrometry.
AU - Allen, L. B.
AU - Siitonen, P. H.
AU - Thompson, H. C., Jr.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 1
SP - 162
EP - 165
SN - 0021-8561
AD - Allen, L. B.: National Center for Toxicological Research, Division of Chemistry, HFT-230, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19971403491. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 7440-38-2, 7440-43-9, 7440-50-8, 7439-92-1, 57-50-1, 7440-31-5. Subject Subsets: Human Nutrition; Sugar Industry
N2 - Estimation of arsenic, cadmium, copper, lead and tin in refined sugar, corn syrups and high-fructose corn syrups by inductively coupled plasma atomic emission spectrometry (ICP-AES) is described. Sample digestion by open vessel/hot plate and closed vessel/microwave techniques is reported. Open vessel digestion was suitable for the simultaneous determination of Cd, Cu and Pb. Average recoveries (5 different sample types) for the open vessel procedure were 98, 88 and 93% for Cd, Cu and Pb, respectively, at 0.10 µg/g. In contrast, microwave digestion yielded average recoveries (5 different sample types) of 92, 83, 89, 85 and 88%, respectively, for As, Cd, Cu, Pb and Sn at 1.0 µg/g. Method detection limits were lower with open vessel digestion versus microwave digestion because of sample volume reduction. Sample introduction included microporous membrane desolvation, which assisted digestion and matrix normalization.
KW - analysis
KW - arsenic
KW - cadmium
KW - copper
KW - corn syrup
KW - determination
KW - estimation
KW - food contamination
KW - fructose syrup
KW - glucose syrups
KW - heavy metals
KW - lead
KW - maize
KW - methodology
KW - refined sugar
KW - sucrose
KW - sweeteners
KW - syrups
KW - tin
KW - trace elements
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - atomic emission spectrometry
KW - corn
KW - food contaminants
KW - maize syrup
KW - methods
KW - microelements
KW - saccharose
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Sugar and Sugar Products (QQ020)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403491&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Socioeconomic inequity in health care: a study of services utilization in Curaçao.
AU - Alberts, J. F.
AU - Sanderman, R.
AU - Eimers, J. M.
AU - Heuvel, W. J. A. van den
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 1997///
VL - 45
IS - 2
SP - 213
EP - 220
SN - 0277-9536
AD - Alberts, J. F.: Medical and Public Health Service of Curaçao, Epidemiology and Research Unit, Curaçao, Netherlands Antilles.
N1 - Accession Number: 19972008200. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Tropical Diseases
KW - health care
KW - health services
KW - socioeconomic status
KW - socioeconomics
KW - utilization
KW - Caribbean
KW - Curacao
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - Developing Countries
KW - Lesser Antilles
KW - Antilles
KW - Caribbean
KW - Netherlands Antilles
KW - Kingdom of the Netherlands
KW - socioeconomic aspects
KW - West Indies
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008200&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of amoxicillin and ampicillin in bovine milk by HPLC with fluorescence detection.
AU - Luo WenHong
AU - Hansen, E. B., Jr.
AU - Ang, C. Y. W.
AU - Deck, J.
AU - Freeman, J. P.
AU - Thompson, H. C., Jr.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 4
SP - 1264
EP - 1268
SN - 0021-8561
AD - Luo WenHong: Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Divisions of Chemistry and Biochemical Toxicology, Jefferson, Arkansas 72079-9502, USA.
N1 - Accession Number: 19970403321. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2. Subject Subsets: Human Nutrition; Dairy Science
N2 - 5-ml samples of raw or processed milk, spiked with amoxicillin and ampicillin at 5, 10 and 20 ng/ml, were diluted to 40 ml with 0.01 M KH2PO4 (pH 4.5) buffer, and the soluble proteins were precipitated by addition of sodium tungstate and sulfuric acid followed by centrifugation. The residues were concentrated by passing the supernatant through a C18 solid phase extraction cartridge and were eluted from the cartridge and reacted with salicylaldehyde to form fluorescent derivatives, which were then analysed using liquid chromatography and fluorescence detection. Average recoveries were >80%, with coefficients of variation <5%. The limit of detection and limit of quantitation for amoxicillin were 1.1 and 2.4 ng/ml, respectively. Corresponding values for ampicillin were 1.0 and 1.7 ng/ml.
KW - amoxicillin
KW - ampicillin
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - chromatography
KW - determination
KW - drug residues
KW - fluorescence
KW - HPLC
KW - milk
KW - amoxycillin
KW - analytical techniques
KW - high performance liquid chromatography
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970403321&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro fermentation of various food fiber fractions.
AU - Casterline, J. L., Jr.
AU - Oles, C. J.
AU - Ku Yuoh
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 7
SP - 2463
EP - 2467
SN - 0021-8561
AD - Casterline, J. L., Jr.: Division of Science and Applied Technology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 19981403806. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Horticultural Science; Human Nutrition; Wheat, Barley & Triticale Abstracts; Soyabeans
N2 - Dietary fibre fractions (DFF) were fermented in vitro with human faecal inocula to examine fibre fermentability and the production of short-chain fatty acids (SCFA). Amylolytic and proteolytic enzyme treatment using the Association of Official Analytical Chemists enzymatic-gravimetric procedure reduced processed food fibre products to DFF by removing gastric enzyme-digestible (non-resistant) components. Total 24-h SCFA production from DFF decreased in the following order: fig > oat = soya > pea > apple > maize = wheat > pear. SCFA production was proportional to the fermentability of the fibres. Fermentation of DFF from fruits such as pear, apple and fig produced low amounts of butyrate. In contrast, less acetate and more propionate and butyrate were produced by fermentation of oat and soya DFF. Major fibre constituents, resistant starch (RS), β-glucan and pectin were also fermented. RS, isolated from starch, produced acetate more slowly than the starch. β-Glucan produced propionate and butyrate in higher amounts than did pectin, starch and RS. This study demonstrated that the fermentability of DFF and the production of SCFA differ among food products. In vitro fermentation of DFF is useful in estimating SCFA production in the human colon.
KW - apples
KW - faeces
KW - fermentation
KW - fibre
KW - figs
KW - in vitro
KW - maize
KW - oats
KW - pears
KW - peas
KW - short chain fatty acids
KW - sources
KW - soyabeans
KW - wheat
KW - Avena sativa
KW - Ficus
KW - Glycine (Fabaceae)
KW - Malus
KW - man
KW - Pisum sativum
KW - Pyrus
KW - Triticum
KW - Zea mays
KW - Avena
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Moraceae
KW - Urticales
KW - dicotyledons
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Rosaceae
KW - Rosales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Pisum
KW - Zea
KW - corn
KW - feces
KW - fiber
KW - pea
KW - pear
KW - soybeans
KW - Physiology of Human Nutrition (VV120)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403806&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of bisphenol-A in reusable polycarbonate food-contact plastics and migration to food-simulating liquids.
AU - Biles, J. E.
AU - McNeal, T. P.
AU - Begley, T. H.
AU - Hollifield, H. C.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 9
SP - 3541
EP - 3544
SN - 0021-8561
AD - Biles, J. E.: U.S. Food and Drug Administration, Office of Premarket Approval, HFS-248, 200 C Street S.W., Washington, D.C. 20204 USA.
N1 - Accession Number: 19981402842. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - Bisphenol-A (BPA) is a principal reactant in the preparation of polycarbonate (PC) plastics and has been shown in in vitro cell proliferation studies to exhibit oestrogen-like characteristics. Reusable infant bottles, water carboys and other housewares are often made of PC. An HPLC protocol was used to determine residual BPA in PC containers and BPA migrated to food simulants in contact with PC under controlled time/temperature conditions. Confirmation of BPA was performed by gas chromatography/mass spectrometry (GC-MS). Residual amounts of BPA found in PC food contact articles ranged from 7 to 58 µg/g. In migration tests the plastic was exposed to water, ethanol/water mixtures, infant formulae and Miglyol (a food oil simulant) in sealed vials at a constant temperature of 65°C, for up to 10 days. BPA in food simulants ranged from 13 to 368% of BPA available to migrate from the polymer. GC-MS methods were applied to the analysis of water stored in reusable PC 5-gal water carboys. The amount of BPA in the water ranged from not detectable to 5 ppb.
KW - analytical methods
KW - contamination
KW - determination
KW - ethanol
KW - foods
KW - gas chromatography
KW - HPLC
KW - hydrolysis
KW - mass spectrometry
KW - packaging
KW - plastics
KW - residues
KW - storage
KW - analytical techniques
KW - bisphenol
KW - bisphenol A
KW - ethyl alcohol
KW - high performance liquid chromatography
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Milk and Dairy Produce (QQ010)
KW - Food Storage and Preservation (QQ110)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402842&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Basic drug screen and quantitation of five toxic alkaloids in milk, chocolate milk, orange juice, and blended vegetable juice.
AU - Smallwood, A. W.
AU - Tschee, C. S.
AU - Satzger, R. D.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 10
SP - 3976
EP - 3979
SN - 0021-8561
AD - Smallwood, A. W.: Food and Drug Administration, Forensic Chemical Center, 1141 Central Parkway, Cincinnati, Ohio 45202, USA.
N1 - Accession Number: 19980401130. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - A convenient and general method for the determination of alkaloids in processed foods and a screening method for basic drugs are presented. The food matrix is removed by mixing the sample with a buffered ion-pair reagent followed by centrifugation. The alkaloids are solid phase extracted from the supernatant. The extracted alkaloids are eluted and then analysed by HPLC using reversed phase ion-pair chromatography. The run is isocratic. A photodiode array detector allows the simultaneous collection of signals at optimum wavelengths for a series of alkaloids in the same sample. The mean percentage recovery of 5 alkaloids in the 4 foods was 87%.
KW - alkaloids
KW - analytical methods
KW - chocolate milk
KW - contamination
KW - foods
KW - fruit juices
KW - HPLC
KW - milk
KW - milk products
KW - orange juice
KW - vegetable juices
KW - analytical techniques
KW - dairy products
KW - high performance liquid chromatography
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401130&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of liquid chromatography with microbial inhibition assay for determination of incurred amoxicillin and ampicillin residues in milk.
AU - Ang, C. Y. W.
AU - Luo WenHong
AU - Call, V. L.
AU - Righter, H. F.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 11
SP - 4351
EP - 4356
SN - 0021-8561
AD - Ang, C. Y. W.: Food and Drug Administration, National Center for Toxicology Research, Division of Chemistry, HFT-230, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, USA.
N1 - Accession Number: 19980401138. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2. Subject Subsets: Veterinary Science; Dairy Science; Human Nutrition; Veterinary Science
N2 - A comparison was made between liquid chromatography (LC) methods and a microbial inhibition (MI) method (Bacillus stearothermophilus disk assay) for the determination of amoxicillin and ampicillin residues in cow milk. One cow was injected intramuscularly with ampicillin (11 mg/kg body weight), and 1 received an intramammary infusion of amoxicillin (62.5 mg/10-ml plastet; 1 plastet/quarter). Milk samples were collected 8-104 h after administration of the drugs. The LC methods using formaldehyde and salicylaldehyde derivatization were applied for the determination of ampicillin and amoxicillin residues, respectively. The LC salicylaldehyde derivatization method was also applied to mixed milk samples for determination of both antibiotics, and the results were in agreement with those determined separately. The MI method was applied to each type of incurred milk. No significant differences were found between the LC and MI assay methods for residue levels within the reliable detection range of the MI method. The LC method was more sensitive than the MI method for residues <10 ng/ml.
KW - amoxicillin
KW - ampicillin
KW - analytical methods
KW - antibiotic residues
KW - comparisons
KW - contamination
KW - determination
KW - drug residues
KW - inhibition
KW - liquid chromatography
KW - milk
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - amoxycillin
KW - analytical techniques
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401138&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Allium chemistry: supercritical fluid extraction and LC-APCI-MS of thiosulfinates and related compounds from homogenates of garlic, onion, and ramp. Identification in garlic and ramp and synthesis of 1-propanesulfinothioic acid S-allyl ester.
AU - Calvey, E. M.
AU - Matusik, J. E.
AU - White, K. D.
AU - DeOrazio, R.
AU - Sha DeYou
AU - Block, E.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 11
SP - 4406
EP - 4413
SN - 0021-8561
AD - Calvey, E. M.: Center for Food Safety and Applied Nutrition, Food and Drink Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19980302130. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science
N2 - Supercritical fluid (SF) extracts of homogenized garlic, ramp (Allium tricoccum) and onion (obtained from local markets in Washington, DC, USA) were characterized by liquid chromatography (LC) and atmospheric pressure chemical ionization MS. The major thiosulfinates from garlic and ramp were readily characterized. Small quantities of ajoene, a potent antithrombotic agent, were found in SF extracts of garlic homogenates. The profiles of onion juice extracts revealed the usual thiosulfinates, zwiebelanes and bissulfine, as well as cepaenes previously identified in extracts of onion juice through extensive isolation steps and spectroscopic methods. The presence of trace quantities of allyl compounds in onion juice and propyl compounds in garlic and ramp homogenates was verified by LC-MS. The presence of these compounds was not readily evident in previous analyses using GC-MS with cold-on-column injection and reversed-phase or normal phase LC with UV detection.
KW - bulbs
KW - chemistry
KW - extraction
KW - garlic
KW - identification
KW - liquid chromatography
KW - mass spectrometry
KW - medicinal plants
KW - onions
KW - organic sulfur compounds
KW - plant composition
KW - plant extracts
KW - synthesis
KW - vegetables
KW - District of Columbia
KW - USA
KW - Alliaceae
KW - Allium
KW - Allium cepa
KW - Allium sativum
KW - Allium tricoccum
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Alliaceae
KW - Liliaceae
KW - Allium
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - organic sulphur compounds
KW - organosulphur compounds
KW - United States of America
KW - vegetable crops
KW - Plant Composition (FF040)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980302130&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of bisphenol A migrating from epoxy can coatings to infant formula liquid concentrates.
AU - Biles, J. E.
AU - McNeal, T. P.
AU - Begley, T. H.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 12
SP - 4697
EP - 4700
SN - 0021-8561
AD - Biles, J. E.: Office of Premarket Approval, HFS-248, US Food and Drug Administration, 200 C Street S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19980401725. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Dairy Science; Human Nutrition; Soyabeans
N2 - Three cans of infant formulae from 4 major manufacturers in the USA purchased in January-February 1996 were studied. Levels of bisphenol A (BPA) in undiluted concentrates ranged from 0.1 to 13 ppb as determined by solid phase extraction/HPLC with fluorescence detection and confirmation by gas chromatography with mass selective detection. Recoveries for milk-based formulae were 86% and those for soya-based formulae were 104%. Coefficients of variation ranged from 2 to 27% for milk-based formulae and from 9 to 27% for soya-based formulae. Detection limit was 0.9 ppb. Fourier transform infrared spectroscopy with 30° specular reflectance/transmittance was used to screen formula cans for epoxy coatings. It is concluded that the method was suitable for screening infant formulae.
KW - coatings
KW - concentrates
KW - containers
KW - contamination
KW - infant formulae
KW - polymers
KW - resins
KW - transfer
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bisphenol
KW - infant formula
KW - infant formulas
KW - protein feeds
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401725&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of baking and frying on the fumonisin B1 content of corn-based foods.
AU - Jackson, L. S.
AU - Katta, S. K.
AU - Fingerhut, D. D.
AU - DeVries, J. W.
AU - Bullerman, L. B.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1997///
VL - 45
IS - 12
SP - 4800
EP - 4805
SN - 0021-8561
AD - Jackson, L. S.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 19981201053. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology; Maize
N2 - The effects of baking and frying on the stability of fumonisin B1 (FB1) spiked into maize-based foods were determined. Baking maize muffins spiked with 5 µg/g (dry weight basis) FB1 at 175 and 200°C for 20 min resulted in 83.7±3.5% and 72.4±5.9% retention of FB1, respectively. At both temperatures, losses of FB1 were significantly (P<0.05) greater at the surface than at the core of the muffins. No significant losses of FB1 were found when spiked maize masa was fried at 140-170°C for 0-6 min. FB1 began to degrade at frying temperatures ≥180°C and times ≥8 min. Frying chips for 15 min at 190°C resulted in 67% loss of FB1. It is concluded that fumonisins are heat stable compounds that survive under most conditions used during baking or frying.
KW - baking
KW - contamination
KW - cooking
KW - foods
KW - frying
KW - fumonisins
KW - heating
KW - inactivation
KW - maize
KW - mycotoxins
KW - processing
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - fungal toxins
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201053&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP).
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
VL - 46
IS - 9
SP - 1
EP - 25
SN - 0149-2195
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention (CDC) Atlanta, GA 30333, USA.
N1 - Accession Number: 19972009517. Publication Type: Miscellaneous. Corporate Author: USA, Advisory Committee on Immunization Practices (ACIP) Language: English. Number of References: 107 ref. Subject Subsets: Public Health
N2 - Recommendations which update information concerning the vaccine and antiviral agents available for controlling influenza during the 1997-98 influenza season are presented. The principal changes include information about the influenza virus strains included in the trivalent vaccine for 1997-98, the vaccination of pregnant and breastfeeding women, and side-effects and adverse reactions.
KW - adverse effects
KW - antiviral agents
KW - disease control
KW - disease prevention
KW - guidelines
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - strains
KW - vaccination
KW - vaccines
KW - viral diseases
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - adverse reactions
KW - flu
KW - immune sensitization
KW - influenzavirus
KW - recommendations
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sarcoidosis among U.S. Navy enlisted men, 1965-1993.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
VL - 46
IS - 23
SP - 539
EP - 543
SN - 0149-2195
AD - Division of Respiratory Disease Studies, Hazard Evaluation, National Institute for Occupational Safety and Health, CDC, Atlanta, GA, USA.
N1 - Accession Number: 19982002636. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report summarizes the findings of an analysis of cases of sarcoidosis diagnosed among active-duty enlisted men in the US Navy (USN). There were 1121 cases of sarcoidosis identified among white and black listed men during the period 1965-93. The results indicate that the incidence of sarcoidosis declined among USN enlisted men during the study period, particularly among blacks, and that the risk for sarcoidosis was statistically associated with the assignment of USN enlisted men to aircraft carriers.
KW - epidemiology
KW - human diseases
KW - military personnel
KW - occupational health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - sarcoidosis
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982002636&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Compendium of animal rabies control 1997.
AU - Satcher, D. (Director)
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
VL - 46
IS - RR-4
SP - 9
EP - 9
SN - 0149-2195
AD - Satcher, D. (Director): U.S. Department of Health and Human Services, Public Health Service Centers for Disease Control and Prevention (CDC) Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19972207288. Publication Type: Miscellaneous. Language: English. Subject Subsets: Veterinary Science
KW - disease control
KW - disease prevention
KW - rabies
KW - vaccines
KW - wild animals
KW - USA
KW - cats
KW - dogs
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972207288&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control and prevention of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP).
AU - Jafari, H. S.
AU - Perkins, B. A.
AU - Wenger, J. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
VL - 46
IS - RR-5
SP - 1
EP - 10
SN - 0149-2195
AD - Jafari, H. S.: Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982003733. Publication Type: Journal Article. Language: English. Number of References: 51 ref.
N2 - The article updates information regarding the efficacy of the polysaccharide vaccine licensed in the USA for use against disease caused by Neisseria meningitidis serogroups A, C, Y and W-135, and discusses indications for use, precautions and contraindications, and future prospects. It also provides information regarding antimicrobial agents for chemoprophylaxis against meningococcal disease, including the use of ciprofloxacin and ceftriaxone as acceptable alternatives to rifampicin in selected populations.
KW - disease control
KW - disease prevention
KW - guidelines
KW - human diseases
KW - immunization
KW - USA
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - immune sensitization
KW - Meningococcus
KW - recommendations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003733&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control and prevention of serogroup C meningococcal disease: evaluation and management of suspected outbreaks: recommendations of the Advisory Committee on Immunization Practices (ACIP).
AU - Perkins, B. A.
AU - Jackson, L. A.
AU - Schillinger, J. A.
AU - Wenger, J. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
VL - 46
IS - RR-5
SP - 13
EP - 21
SN - 0149-2195
AD - Perkins, B. A.: Centers for Disease Control and Prevention (CDC), Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982003734. Publication Type: Journal Article. Language: English. Number of References: 6 ref.
N2 - The report gives a background to meningococcal disease in the USA (including a description of endemic disease, control of outbreaks, and outbreak settings), and defines terms used in relation to suspected serogroup C meningococcal disease (SCMD), including confirmed case and probable case; close contacts; primary, secondary and co-primary cases; organization- and community-based outbreaks; population at risk; and vaccination group and seasonality of outbreaks. It then describes 10 steps for the evaluation and management of SCMD outbreaks. The principles described also apply to suspected outbreaks caused by meningococcal serogroups A, Y and W-135. Finally, vaccination and other control measures are discussed.
KW - disease control
KW - epidemiology
KW - guidelines
KW - human diseases
KW - outbreaks
KW - surveillance
KW - USA
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - Meningococcus
KW - recommendations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003734&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic health effects of microbial foodborne disease.
AU - Bunning, V. K.
AU - Lindsay, J. A.
AU - Archer, D. L.
JO - World Health Statistics Quarterly
JF - World Health Statistics Quarterly
Y1 - 1997///
VL - 50
IS - 1/2
SP - 51
EP - 56
SN - 0379-8070
AD - Bunning, V. K.: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD, United States of America.
N1 - Accession Number: 19981403986. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 45 ref. Subject Subsets: Human Nutrition
N2 - The ways in which foodborne pathogens serve as 'triggers' in chronic disease pathology are reviewed. Rheumatoid disease (septic arthritis, aseptic arthritis), inflammatory bowel disease and autoimmune disorders can be triggered by foodborne pathogens or their toxins. Haemolytic uraemic syndrome caused by Escherichia coli O157:H7 and Guillain-Barré syndrome caused by Campylobacter are discussed.
KW - arthritis
KW - autoimmune diseases
KW - food poisoning
KW - foodborne diseases
KW - health
KW - intestinal diseases
KW - kidney diseases
KW - pathogens
KW - reviews
KW - rheumatism
KW - rheumatoid arthritis
KW - uraemia
KW - Campylobacter
KW - Escherichia coli
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - azotaemia
KW - azotemia
KW - bacterium
KW - E. coli
KW - enteropathy
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - uremia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403986&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modernizing food control systems: the experience of Thailand.
AU - Pothisiri, P.
JO - World Health Statistics Quarterly
JF - World Health Statistics Quarterly
Y1 - 1997///
VL - 50
IS - 1/2
SP - 150
EP - 154
SN - 0379-8070
AD - Pothisiri, P.: Food and Drug Administration, Bangkok, Thailand.
N1 - Accession Number: 19981403997. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 6 ref. Subject Subsets: Human Nutrition
N2 - Efforts to modernize food safety information systems in Thailand are discussed. In 1995, ~30% of food samples collected in regional areas and 18% of those collected in metropolitan Bangkok did not comply with established standards because of contamination by biological or chemical agents. Food control strategies and regulatory enforcement are discussed. In 1995, the Thai FDA implemented a series of measures to modernize the food control system. These related to changes in the working system and infrastructure and the information system, the establishment of regional technical centres, the revision of food legislation, strengthening cooperation and coordination among concerned agencies, implementation of the Hazard Analysis and Critical Control Point (HACCP) system, international cooperation, and improvement of public education and consumer participation.
KW - food hygiene
KW - food safety
KW - information systems
KW - public health
KW - Thailand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403997&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid and sensitive detection of cell-associated HIV-1 in latently infected cell lines and in patient cells using sodium-n-butyrate induction and RT-PCR.
AU - Kashanchi, F.
AU - Melpolder, J. C.
AU - Epstein, J. S.
AU - Sadaie, M. R.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 1997///
VL - 52
IS - 2
SP - 179
EP - 189
SN - 0146-6615
AD - Kashanchi, F.: Correspondence address [Sadaie, M. R.]: Laboratory of Immunochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19972006997. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9068-38-6, 63231-63-0.
N2 - To develop a rapid and sensitive means of detecting cell-associated HIV, donor cells from HIV seropositive patients were treated with the potent viral activator sodium-n-butyrate (NaB) and subsequently assayed by both in situ RNA hybridization and reverse transcriptase polymerase chain reaction (RT-PCR). The sensitivity of RT-PCR was estimated to be equivalent to 1 × 10-16 g (0.1 fg) or approx. 64 copies of the input standard viral RNA per reaction. The present study took advantage of the ability of NaB to introduce changes in chromatin structure of latently infected cells, leading to increased HIV gene expression. Human ACH-2 and U1 cell lines were used as representatives of T-lymphocytic and monocytoid cells harbouring latent inducible proviruses. HIV gene expression was readily detected when these cells were treated with NaB.
KW - assays
KW - cell lines
KW - detection
KW - gene expression
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - hybridization
KW - microbiology
KW - patients
KW - polymerase chain reaction
KW - reverse transcriptase
KW - RNA
KW - Human immunodeficiency virus 1
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - PCR
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972006997&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Puumala virus and two genetic variants of Tula virus are present in Austrian rodents.
AU - Bowen, M. D.
AU - Gelbmann, W.
AU - Ksiazek, T. G.
AU - Nichol, S. T.
AU - Nowotny, N.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 1997///
VL - 53
IS - 2
SP - 174
EP - 181
SN - 0146-6615
AD - Bowen, M. D.: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982001760. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - To identify the hantaviruses that are present in Austria, 5 species of rodents were trapped in 8 areas of Austria and screened for virus antibodies, antigen and RNA. Hantaviruses were detected in 2 species, Clethrionomys glareolus and Microtus arvalis, by reverse transcription-polymerase chain reaction (RT-PCR). RT-PCR products from C. glareolus tissues yielded a unique Puumala virus sequence distinct from Puumala virus sequences reported from other parts of Europe. RT-PCR products from M. arvalis tissues yielded 2 genetically distinct Tula virus sequences, one similar to sequences reported from Slovakia and the Czech Republic and another that appeared to be a novel genetic variant of Tula virus.
KW - epidemiology
KW - polymerase chain reaction
KW - Austria
KW - Bunyaviridae
KW - Clethrionomys glareolus
KW - Hantavirus
KW - Microtus arvalis
KW - Puumala virus
KW - rodents
KW - Tula virus
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Clethrionomys
KW - Arvicolinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bunyaviridae
KW - Microtus
KW - Hantavirus
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - PCR
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001760&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos.
AU - Stayner, L.
AU - Smith, R.
AU - Bailer, J.
AU - Gilbert, S.
AU - Steenland, K.
AU - Dement, J.
AU - Brown, D.
AU - Lemen, R.
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
Y1 - 1997///
VL - 54
IS - 9
SP - 646
EP - 652
SN - 1351-0711
AD - Stayner, L.: Centers for Disease Control, National Institute for Occupational Safety and Health, Robert A Taff Laboratories, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998, USA.
N1 - Accession Number: 19982005393. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 1332-21-4, 12001-29-5.
N2 - Data were examined from an update of a cohort mortality study of workers (1247 white male, 546 non-white male, 1229 white women and 19 non-white women) who had been employed in a textile factory in South Carolina, USA, for ≥1 month between 1 January 1940 and 31 December 1990, to evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos. Alternative exposure-response models were evaluated with Poisson regression and a model to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach, accounting for competing causes of death. A highly significant exposure-response relation was found for both lung cancer and asbestosis. This relation was linear for lung cancer and non-linear for asbestosis on a multiplicative scale. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis. The excess lifetime risk for white men exposed for 45 years at the Occupational Safety and Health Administration standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer and 2/1000 for asbestosis.
KW - asbestos
KW - asbestos workers
KW - asbestosis
KW - chrysotile
KW - exposure
KW - human diseases
KW - lung cancer
KW - lungs
KW - mortality
KW - neoplasms
KW - occupational hazards
KW - respiratory diseases
KW - risk factors
KW - textile workers
KW - South Carolina
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - cancers
KW - death rate
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005393&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action.
AU - Divi, R. L.
AU - Chang, H. C.
AU - Doerge, D. R.
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 1997///
VL - 54
IS - 10
SP - 1087
EP - 1096
SN - 0006-2952
AD - Divi, R. L.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981400820. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 486-66-8, 446-72-0, 20461-54-5, 51-48-9. Subject Subsets: Human Nutrition; Soyabeans
N2 - Analysis of the soyabean extract using HPLC, UV-VIS spectrophotometry and LC-MS led to identification of the isoflavones genistein and daidzein as major components by direct comparison with authentic standard reference isoflavones. HPLC fractionation and enzymatic assay of the soyabean extract showed that the components responsible for inhibition of thyroid peroxidase (TPO)-catalysed reactions coeluted with daidzein and genistein. In the presence of iodide, genistein and daidzein blocked TPO-catalysed tyrosine iodination by acting as alternate substrates, yielding mono-, di- and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goitre thyroglobulin as substrates for the coupling reaction. Incubation of isoflavone with TPO in the presence of H2O2 caused irreversible inactivation of the enzyme; however, the presence of iodide in the incubations completely abolished the inactivation. The IC50 values for inhibition of TPO-catalysed reactions by genistein and daidzein were ca. 1-10 µM, concentrations that approach the total isoflavone levels (ca. 1 µM) previously measured in plasma from humans consuming soya products. It is concluded that because inhibition of thyroid hormone synthesis can induce goitre and thyroid neoplasia in rodents, delineation of anti-thyroid mechanisms for soya isoflavones may be important for extrapolating goitrogenic hazards identified in chronic rodent assays to humans consuming soya products.
KW - characterization
KW - daidzein
KW - genistein
KW - in vitro
KW - inhibition
KW - iodide
KW - iodination
KW - isoflavones
KW - isolation
KW - soyabeans
KW - synthesis
KW - thyroid hormones
KW - thyroxine
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - biochanin A
KW - soybeans
KW - Crop Produce (QQ050)
KW - Physiology of Human Nutrition (VV120)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400820&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States.
AU - Mills, J. N.
AU - Ksiazek, T. G.
AU - Ellis, B. A.
AU - Rollin, P. E.
AU - Nichol, S. T.
AU - Yates, T. L.
AU - Gannon, W. L.
AU - Levy, C. E.
AU - Engelthaler, D. M.
AU - Davis, T.
AU - Tanda, D. T.
AU - Frampton, J. W.
AU - Nichols, C. R.
AU - Peters, C. J.
AU - Childs, J. E.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 1997///
VL - 56
IS - 3
SP - 273
EP - 284
SN - 0002-9637
AD - Mills, J. N.: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Mailstop G-13, Public Health Service, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 19970502137. Publication Type: Journal Article. Language: English. Number of References: 39 ref.
N2 - The distribution and prevalence of antibody reactive with Sin Nombre virus were determined in mammals in biotic communities of the southwestern USA. Small mammals (n = 3069) of 69 species were trapped in 9 communities from lower Sonoran desert to alpine tundra. Antibody was found in rodents from all communities (overall prevalence = 6.3%); prevalence was lowest at the altitudinal and climatic extremes (0.4% in desert and 2.0% in alpine tundra). Antibody occurred in 11% of 928 deer mice (Peromyscus maniculatus), 20% of 355 brush mice (P. boylii), 23% of 35 western harvest mice (Reithrodontomys megalotis), and 12% of 24 Mexican voles (Microtus mexicanus). No infected deer mice were found in desert habitat; prevalence varied from 4% in chaparral to 17% in pinyon-juniper. Brush mice were frequently infected in chaparral and montane forest (25%). Seropositivity was higher in males and in heavier animals, suggesting horizontal transmission among adult males. Decreasing prevalence with age among the youngest deer mice suggests that infected dams confer passive immunity to pups.
KW - arid lands
KW - chaparral
KW - deserts
KW - forests
KW - grasslands
KW - habitats
KW - hosts
KW - meadows
KW - mountains
KW - reservoir hosts
KW - scrub
KW - serological surveys
KW - small mammals
KW - wild animals
KW - zoonoses
KW - Arizona
KW - Colorado
KW - New Mexico
KW - USA
KW - Utah
KW - Hantavirus
KW - Microtus
KW - Microtus mexicanus
KW - Peromyscus
KW - Peromyscus boylii
KW - Peromyscus maniculatus
KW - Reithrodontomys
KW - Reithrodontomys megalotis
KW - rodents
KW - Sin Nombre virus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Arvicolinae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Microtus
KW - Sigmodontinae
KW - Peromyscus
KW - Reithrodontomys
KW - Hantavirus
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Great Plains States of USA
KW - animal reservoirs
KW - seroepidemiology
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970502137&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - α-Tocopherol, total vitamin A and total fat in margarines and margarine-like products.
AU - Rader, J. I.
AU - Weaver, C. M.
AU - Patrascu, L.
AU - Ali, L. H.
AU - Angyal, G.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1997///
VL - 58
IS - 4
SP - 373
EP - 379
SN - 0308-8146
AD - Rader, J. I.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971404596. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 59-02-9, 7235-40-7, 68-26-8, 8001-22-7, 8001-21-6, 1406-18-4. Subject Subsets: Human Nutrition; Soyabeans
N2 - Concentrations of vitamin E (measured as α-tocopherol), vitamin A (as retinol and β-carotene), and fat were determined in 19 margarines and margarine-like products carrying reduced-fat and no-fat claims. Samples were saponified, extracted with petroleum ether, and analysed by HPLC. Total fat contents calculated from label declarations were 0-80%. Analysed values were 3-81%. The α-tocopherol contents were highly variable. Products labelled as containing maize, sunflower and cottonseed oils had the highest levels of vitamin E. Those labelled as containing soyabean oil contributed less vitamin E. Among oils of similar composition, α-tocopherol content decreased with decreasing fat content. All products contained vitamin A concentrations of 250-500 IU/14 g. Analysed concentrations of total vitamin A in the products were 59-196% of amounts declared on the labels. All products identified β-carotene as a colorant.
KW - alpha-tocopherol
KW - beta-carotene
KW - cottonseed oil
KW - fats
KW - HPLC
KW - low fat products
KW - maize oil
KW - margarine
KW - retinol
KW - soyabean oil
KW - sunflower oil
KW - vitamin E
KW - vitamins
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - corn oil
KW - high performance liquid chromatography
KW - soybean oil
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404596&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevated lead contamination in homes of construction workers.
AU - Piacitelli, G. M.
AU - Whelan, E. A.
AU - Sieber, W. K.
AU - Gerwel, B.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1997///
VL - 58
IS - 6
SP - 447
EP - 454
SN - 0002-8894
AD - Piacitelli, G. M.: National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19972005804. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - National Institute for Occupational Safety and Health investigators in the USA studied lead exposures among 37 families of construction workers in 1994; 22 neighbourhood families with no known lead exposures were included for comparison. Workers were identified as having blood lead levels ≥25 µg/dl. The levels of lead contamination on hands and interior surfaces of homes and automobiles of study participants were investigated. The hands of lead-exposed workers were 7-fold more contaminated with lead compared with control workers; no difference was found between exposed and control family members' hands. Surface lead contamination was significantly higher in automobiles driven by the lead-exposed workers; some locations, such as armrests, were 10-fold more contaminated for the exposed group. Surface lead concentrations were significantly higher for exposed homes compared with control homes in rooms where work clothing was changed. While environmental sources of lead were also evaluated, study results strongly indicated that construction workers' occupational exposures together with poor hygiene practices were the primary causes of lead contamination. Requirements intended to prevent "take-home" lead exposures were reported by workers to be infrequently followed by employers. It is noted that these findings may be limited in representativeness since only highly exposed workers were selected from a specific geographical area. Targeted education and enforcement efforts are recommended to help ensure that preventive measures are adequately practiced throughout the construction industry.
KW - contamination
KW - dwellings
KW - environment
KW - exposure
KW - families
KW - hands
KW - human diseases
KW - hygiene
KW - lead
KW - motor cars
KW - occupational health
KW - occupations
KW - safety
KW - safety at work
KW - toxicology
KW - workers
KW - New Jersey
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - automobiles
KW - occupational safety
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972005804&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A sampling and analytical method for the simultaneous determination of multiple organonitrogen pesticides in air.
AU - Kennedy, E. R.
AU - Lin JunJie
AU - Reynolds, J. M.
AU - Perkins, J. B.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1997///
VL - 58
IS - 10
SP - 720
EP - 725
SN - 0002-8894
AD - Kennedy, E. R.: U.S. Department of Health and Human Services, U.S. Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19980502977. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 116-06-3, 17804-35-2, 133-06-2, 63-25-2, 1563-66-2, 101-21-3, 330-54-1, 22259-30-9, 23422-53-9, 2032-65-7, 16752-77-5, 23135-22-0, 122-42-9, 114-26-1, 28249-77-6. Subject Subsets: Medical & Veterinary Entomology; Weeds; Agricultural Entomology
N2 - An air sampling and analytical method was developed for organonitrogen pesticides using a combined filter and XAD-2 sorbent sampler and high performance liquid chromatography-ultraviolet detection. The method was evaluated for 14 organonitrogen pesticides by National Institute for Occupational Safety and Health evaluation guidelines and procedures. Evaluation experiments addressed limits of detection and quantitation, analytical recovery, sampler capacity, sample stability, and precision and bias over a range of 12 to 240 µg/sample. Samples were stable when stored for up to 30 days under either ambient or refrigerated conditions. Based on the finding of this work, 10 of the 14 compounds studied (aldicarb, captan, carbaryl, carbofuran, chlorpropham, diuron, formetanate, methiocarb, oxamyl, propham) can be successfully determined simultaneously using one method with an accuracy of better than ±25% of the true value with 95% confidence. Two other compounds (carbendazim/benomyl, methomyl) can be measured with the same accuracy over a more limited concentration range. The remaining 2 compounds (propoxur, thiobencarb) may meet this criterion, but additional samples would need to be included in the data analysis. With the current data, these 2 compounds can be determined with an accuracy of better than ±27% of the true value with 95% confidence.
KW - acaricide residues
KW - acaricides
KW - agricultural entomology
KW - air
KW - aldicarb
KW - analytical methods
KW - benomyl
KW - captan
KW - carbamates
KW - carbaryl
KW - carbofuran
KW - chlorpropham
KW - detection
KW - diuron
KW - formetanate
KW - fungicide residues
KW - fungicides
KW - herbicide residues
KW - herbicides
KW - insecticide residues
KW - insecticides
KW - methiocarb
KW - methomyl
KW - oxamyl
KW - pesticide residues
KW - pesticides
KW - propham
KW - propoxur
KW - sampling
KW - techniques
KW - thiobencarb
KW - analytical techniques
KW - benthiocarb
KW - DCMU
KW - fundazol
KW - fungistats
KW - organonitrogen pesticides
KW - sampling techniques
KW - weedicides
KW - weedkillers
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
KW - Chemistry (ZZ600) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502977&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of capillary column gas chromatographic and AOAC gravimetric procedures for total fat and distribution of fatty acids in foods.
AU - Ali, L. H.
AU - Angyal, G.
AU - Weaver, C. M.
AU - Rader, J. I.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1997///
VL - 58
IS - 1-2
SP - 149
EP - 160
SN - 0308-8146
AD - Ali, L. H.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19971402367. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Total fat content and fatty acid composition of 43 US food products were determined after acid hydrolysis by gas chromatography using an SP-2560 flexible fused silica capillary column. The foods included breakfast foods, meat products, snacks, baby foods, infant formulae, margarines, mayonnaise and rapeseed oil. Total fat content determined by the gas chromatographic method was compared with fat content determined by AOAC gravimetric method 922.06 for all food products. Total fat, saturated fat and unsaturated fat contents of the foods determined by the gas chromatographic method were 0.9-96.7, 0.2-16.8 and 0.5-89.3%, respectively. Trans fatty acids hexadecenoate (t-16:1), elaidic (t-18:1) and octadecadienoate (t,t-18:2) were identified by comparison of their retention times with those of known standards and quantitated. These fatty acids were present in foods at concentrations of 0.25-1.50 (t-16:1), 0.87-268.32 (t-18:1) and 0.23-7.92 (t,t-18:2) mg/g, respectively.
KW - breakfast cereals
KW - composition
KW - determination
KW - estimation
KW - fats
KW - fatty acids
KW - food products
KW - foods
KW - infant foods
KW - infant formulae
KW - margarine
KW - meat products
KW - milk products
KW - rapeseed oil
KW - saturated fats
KW - snacks
KW - trans fatty acids
KW - unsaturated fats
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - dairy products
KW - infant formula
KW - infant formulas
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971402367&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Collaborative study: determination of retinol and carotene by high-performance liquid chromatography.
AU - Bueno, M. P.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1997///
VL - 59
IS - 1
SP - 165
EP - 170
SN - 0308-8146
AD - Bueno, M. P.: Division of Science and Applied Technology, Office of Food Labeling, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19971405063. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 7235-40-7, 68-26-8. Subject Subsets: Horticultural Science; Human Nutrition; Animal Nutrition; Poultry; Wheat, Barley & Triticale Abstracts
N2 - 17 laboratories participated in the analysis of 10 products (a cereal product, powdered infant formula, chicken feed, pureed carrots, vegetable juice, low-fat milk, baby food (squash) and β-carotene and retinol capsules) for β-carotene and retinol by HPLC. Test materials were saponified and the nonsaponifiables were extracted with petroleum ether. The extract was injected into the liquid chromatograph for determination of β-carotene at 450 nm/436 nm, using a C18 reversed-phase column with a mobile phase of acetonitrile:methylene chloride:methanol:water (70:20:8:2, v/v). Retinol was determined at 325 nm/313 nm by using a C18 reversed-phase column with a mobile phase of methanol:water (90:10, v/v). The biological activities of retinol and β-carotene expressed in international units were summed to give total activity. The repeatability (within laboratory) coefficients of variation ranged from 3.46 to 15.65% and the reproducibility (among laboratories) coefficients of variation ranged from 5.34 to 15.77%.
KW - analytical methods
KW - beta-carotene
KW - carrots
KW - cereal products
KW - cereals
KW - estimation
KW - feeds
KW - foods
KW - infant formulae
KW - milk
KW - poultry
KW - retinol
KW - supplements
KW - vegetable juices
KW - vitamins
KW - Daucus carota
KW - fowls
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - analytical techniques
KW - Araliales
KW - axerophthol
KW - chickens
KW - domesticated birds
KW - feeding stuffs
KW - infant formula
KW - infant formulas
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Feed Composition and Quality (RR300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405063&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Laboratory studies for the approval of aquaculture drugs.
AU - Greenlees, K. J.
JO - Progressive Fish-Culturist
JF - Progressive Fish-Culturist
Y1 - 1997///
VL - 59
IS - 2
SP - 141
EP - 148
SN - 0033-0779
AD - Greenlees, K. J.: U.S. Food and Drug Administration, Center for Veterinary Medicine HFV-153, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19972212473. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Veterinary Science
KW - aquaculture
KW - clinical trials
KW - drugs
KW - efficacy
KW - food safety
KW - regulations
KW - reviews
KW - safety
KW - USA
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - medicines
KW - pharmaceuticals
KW - rules
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Laws and Regulations (DD500)
KW - Aquaculture (Animals) (MM120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972212473&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence and survival of Listeria monocytogenes in ready-to-eat seafood products.
AU - McCarthy, S. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1997///
VL - 60
IS - 4
SP - 372
EP - 376
SN - 0362-028X
AD - McCarthy, S. A.: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528-0158, USA.
N1 - Accession Number: 19971407709. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - The effects of processing and storage conditions on the incidence and survival of L. monocytogenes on crayfish (Procambarus sp.), crab meat (Callinectes sapidus) and smoked salmon (Salmo salar) were evaluated. L. monocytogenes was detected in 3% of whole boiled market crayfish samples and 17% of frozen vacuum-packaged partially cooked crayfish tail meat, but not from boiled crab meat or smoked salmon. Contamination was most likely due to post-process handling since cooking (5 min boil or 20 min steep) decreased L. monocytogenes to non-detectable concentrations in laboratory-contaminated crawfish. Cooked whole crayfish were inoculated internally and externally with 3.0 log cfu of L. monocytogenes per g and incubated at 22 or 30°C for 6 h. The greatest increase in numbers of cells, 1.9 log cfu/g (determined by standard plate count), occurred at 30°C on externally contaminated crayfish. There was no change in numbers of L. monocytogenes during cold storage (6°C, 5 days; -20°C, 15 days). There was little change in cell numbers associated with products stored at 22 or -20°C. At 6°C, numbers of cells associated with crab meat increased by 3.8 log MPN/g after 6 days; however, there was no increase in numbers of cells associated with salmon. It is concluded that the survival and growth characteristics of L. monocytogenes are dependent on storage time and temperature and the nature of the seafood product.
KW - boiling
KW - cold storage
KW - cooking
KW - crab meat
KW - crayfish
KW - growth
KW - incidence
KW - pathogens
KW - processing
KW - seafoods
KW - shellfish
KW - storage
KW - survival
KW - bacteria
KW - Callinectes sapidus
KW - listeria monocytogenes
KW - Procambarus
KW - salmo
KW - salmon
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - prokaryotes
KW - Callinectes
KW - Portunidae
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Cambaridae
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Food Storage and Preservation (QQ110)
KW - Storage Problems and Pests of Food (QQ111)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407709&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the Listertest™ method for quantitation of Listeria monocytogenes in seafoods.
AU - McCarthy, S. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1997///
VL - 60
IS - 4
SP - 424
EP - 425
SN - 0362-028X
AD - McCarthy, S. A.: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528-0158, USA.
N1 - Accession Number: 19971407714. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration most probable number (MPN) method and the Listertest™ (immunomagnetic capture) were used to enumerate L. monocytogenes on laboratory-inoculated cooked crab meat (Callinectes sapidus) and cold-smoked salmon (Salmo salar). The products were inoculated with <1.0-4.0 log cfu of L. monocytogenes per g and analysed immediately. In the analyses of crab meat, the results obtained by the MPN method were significantly lower (P<0.05) than the Listertest™. There was no significant difference (P<0.05) between results produced by MPN and the Listertest™ in analyses of smoked salmon. The methods had the same variance in the quantitation of L. monocytogenes in these seafood products.It is concluded that the Listertest™ was more sensitive than MPN for the detection and enumeration of very low (<10 cfu/g) numbers of L. monocytogenes. Listertest also took less time and was simpler to perform than MPN>.
KW - analytical methods
KW - evaluation
KW - seafoods
KW - Atlantic salmon
KW - Callinectes sapidus
KW - listeria monocytogenes
KW - salmon
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - diadromous fishes
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Callinectes
KW - Portunidae
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Salmo salar
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407714&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dietary flaxseed on fatty acid composition, superoxide, nitric oxide generation and antilisterial activity of peritoneal macrophages from female Sprague-Dawley rats.
AU - Babu, U. S.
AU - Bunning, V. K.
AU - Wiesenfled, P.
AU - Raybourne, R. B.
AU - O'Donnell, M.
JO - Life Sciences
JF - Life Sciences
Y1 - 1997///
VL - 60
IS - 8
SP - 545
EP - 554
SN - 0024-3205
AD - Babu, U. S.: Division of Science and Applied Technology, Office of Special Nutritionals, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19971403466. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 506-32-1, 25167-62-8, 10417-94-4, 463-40-1, 10102-43-9, 57-10-3, 57-11-4. Subject Subsets: Human Nutrition
N2 - The impact of ground flaxseed (FS) or flaxseed meal (FSM) diets on the fatty acid composition and functions of rat peritoneal exudate cells (PEC) was determined. Female weanling Sprague-Dawley rats (n=10 per group) were fed isoenergetic AIN-76 diets supplemented with 0.0 or 10.0% (w/w) FS or 6.2% (w/w) FSM. At the end of 56-days, rat serum and thioglycollate-elicited PEC were analysed for total lipid fatty acids. Production of nitric oxide (NO) and superoxide (O2-), Listeria monocytogenes (LM) phagocytic index and antilisterial activity of resident PEC were also assessed. An increase (P<0.05) in α-linolenic, eicosapentaenoic and docosahexaenoic acids, as well as a reduction (P<0.05) in arachidonic acid was observed in the serum of rats fed 10% FS. Dietary FS caused a reduction (P<0.05) in palmitic acid and an increase (P<0.05) in stearic acid of PEC. Defatted FSM produced an increase (P<0.05) in long chain fatty acids, which included eicosadiaenoic acid in PEC and docosahexaenoic acid in serum. PEC from rats fed 10.0% FS produced less (about 50%, P<0.05) O2- in response to phorbol myristate acetate (PMA), than did PEC from control rats; dietary treatment had no effect on O2- in response to LM. FSM had no impact on the O2- production by PEC in response to PMA or LM. Antilisterial activity of PEC was determined by comparing bacterial uptake after 1 h with recovery 24 h later. Despite comparably equivalent bacterial uptake, few viable intracellular LM were recovered at T=24 for all test samples, indicating that, regardless of the dietary treatment, PEC were able to handle the in vitro LM infection. This bacterial clearance was accompanied by equivalent NO generation by PEC from each dietary group in response to LM. In conclusion, dietary FS produced significant changes in fatty acid composition of serum and PEC, inhibited O2- generation by PEC and was ineffectual to NO production by and antilisterial activity of PEC.
KW - activity
KW - arachidonic acid
KW - composition
KW - docosahexaenoic acid
KW - eicosapentaenoic acid
KW - fatty acids
KW - flax
KW - free radicals
KW - immunity
KW - intake
KW - linolenic acid
KW - linseed
KW - long chain fatty acids
KW - macrophages
KW - nitric oxide
KW - palmitic acid
KW - phagocytosis
KW - production
KW - seeds
KW - stearic acid
KW - Linum usitatissimum
KW - Listeria monocytogenes
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - bacterium
KW - eicosatetraenoic acid
KW - hexadecanoic acid
KW - octadecanoic acid
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971403466&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Shelf life and toxin development by Clostridium botulinum during storage of modified-atmosphere-packaged fresh aquacultured salmon fillets.
AU - Reddy, N. R.
AU - Solomon, H. M.
AU - Yep, H.
AU - Roman, M. G.
AU - Rhodehamel, E. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1997///
VL - 60
IS - 9
SP - 1055
EP - 1063
SN - 0362-028X
AD - Reddy, N. R.: National Center for Food Safety and Technology, US Food and Drug Administration, Division of Food Processing and Packaging, 6502 S. Archer Road, Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 19981402272. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition
N2 - Shelf life (onset of sensory spoilage) and the potential for toxin production by C. botulinum type E in retail-type packages of fresh aquacultured salmon fillets packaged in high-barrier film bags under selected atmospheres (100% air, a modified atmosphere containing 75% CO2:25% N2, and vacuum) and stored under refrigeration (4°C) and temperature-abuse conditions (8 and 16°C) were investigated. Chemical spoilage indicators (trimethylamine and surface pH) and microbial populations were compared with sensory spoilage characteristics. Storage temperature influenced the time to onset of sensory spoilage and toxin development in salmon fillets packaged in all atmospheres. The shelf life of fillets packaged in all atmospheres decreased with increase of storage temperature from 4 to 16°C. Trimethylamine content associated with the onset of spoilage for 100% air-packaged fillets increased as storage temperature increased. However, for modified-atmosphere-packaged fillets, the trimethylamine content associated with the onset of spoilage increased as storage temperature decreased from 8 to 4°C. Surface pH was not a good spoilage indicator for modified-atmosphere-packaged fillets. Toxin development preceded sensory spoilage at 16°C storage for fillets packaged in modified atmospheres. Toxin development coincided with sensory spoilage or was slightly delayed for the fillets packaged in all the atmospheres at 8°C storage. At 4°C none of the fillets packaged in either of the atmospheres developed toxin, even 20 days after spoilage as determined by sensory characteristics.
KW - bacterial toxins
KW - food spoilage
KW - packaging
KW - storage
KW - storage life
KW - Clostridium botulinum
KW - salmon
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - bacterium
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981402272&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative study of recovery of Salmonella javiana from Mozzarella cheese by two official analytical procedures.
AU - Hoffman, C. A.
AU - Wagner, D. E.
AU - Tatini, S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1997///
VL - 60
IS - 12
SP - 1493
EP - 1496
SN - 0362-028X
AD - Hoffman, C. A.: Food and Drug Administration, 240 Hennepin Ave., Minneapolis, Minnesota 55401, USA.
N1 - Accession Number: 19980401892. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The Association of Official Analytical Chemists (AOAC) and the Canadian Health Protection Branch (CHPB) methods for detection of Salmonella spp. were compared for recovery of S. javiana from experimentally contaminated Mozzarella cheese. 10 trials were conducted with 2 levels of random surface contamination of 25-g samples of cheese. Five samples/level were randomly chosen and analysed. The results showed that there was no significant difference between the 2 methods (P<0.05). When S. javiana was added directly to grated cheese and analysed immediately, the recovery was identical with both methods (7 of 10 samples were positive). However, when the directly contaminated cheese was stored for 7 days prior to analysis, the AOAC method showed only 3 positive samples, whereas the CHPB yielded 6. During pre-enrichment, pH decreased to a greater extent with the AOAC method (7.4 to 4.4) than with the CHPB method (7.6 to 5.7) in 24 h. This decrease resulted in a 1 log higher number of S. javiana counts in the latter (106 and 107 c.f.u./ml respectively).
KW - analytical methods
KW - cheeses
KW - grated cheese
KW - microbial contamination
KW - Mozzarella cheese
KW - recovery
KW - storage
KW - USA
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - bacterium
KW - Salmonella javiana
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401892&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin.
AU - Burkhart, G. A.
AU - Sevka, M. J.
AU - Temple, R.
AU - Honig, P. K.
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
Y1 - 1997///
VL - 61
IS - 1
SP - 93
EP - 96
SN - 0009-9236
AD - Burkhart, G. A.: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19971201686. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 114-07-8, 65277-42-1. Subject Subsets: Medical & Veterinary Mycology
N2 - Using paid pharmacy claims during 1988-94 in the state Medicaid programmes from Michigan and Ohio, USA, and a large health maintenance organization, temporal changes in filling terfenadine prescriptions within 2 days of those for oral ketoconazole or oral erythromycin were studied. There were rapid declines in the rates of filling these prescriptions in all 3 databases that coincided with 1992 publicity about the cardiovascular risk of terfenadine. It is suggested that the use of terfenadine with contraindicated medications declined in response to relabelling and publicity concerning the safe use of the drug.
KW - adverse effects
KW - antagonism
KW - antifungal agents
KW - drug antagonism
KW - drugs
KW - erythromycin
KW - fungicides
KW - ketoconazole
KW - prescriptions
KW - safety
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - fungistats
KW - medicines
KW - pharmaceuticals
KW - terfenadine
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201686&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Distribution of Vibrio vulnificus phage in oyster tissues and other estuarine habitats.
AU - DePaola, A.
AU - McLeroy, S.
AU - McManus, G.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1997///
VL - 63
IS - 6
SP - 2464
EP - 2467
SN - 0099-2240
AD - DePaola, A.: Gulf Coast Seafood Laboratory, US Food and Drug Administration, PO Box 158, Dauphin Island, AL 36258, USA.
N1 - Accession Number: 19981400607. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Veterinary Science; Human Nutrition
N2 - Phages [bacteriophages] which lyse V. vulnificus were found in estuarine waters, sediments, plankton, crustacea, molluscan shellfish and the intestines of finfish of the US Gulf Coast, but no apparent relationship between densities of V. vulnificus and its phages was observed. Phage diversity and abundance in molluscan shellfish were much greater than in other habitats. V. vulnificus phages isolated from oysters did not lyse other mesophilic bacteria isolated from oysters. Both V. vulnificus and its phages were found in a variety of oyster tissues and fluids with lowest densities in the haemolymph and mantle fluid. The findings suggest a close ecological relationship between V. vulnificus phages and molluscan shellfish.
KW - bacteriophages
KW - distribution
KW - food contamination
KW - lysis
KW - oysters
KW - tissues
KW - USA
KW - bacteria
KW - Vibrio vulnificus
KW - viruses
KW - viruses
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - prokaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - phages
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981400607&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular characteristics of Junin virus.
AU - Bushar, G.
AU - Sagripanti, J. L.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 1997///
VL - 63
IS - 1/2
SP - 27
EP - 35
SN - 0166-0934
AD - Bushar, G.: Molecular Biology Branch (HFZ-113), Center for Devices and Radiological Health, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19980501842. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 63231-63-0.
N2 - Results suggest that protein, glycerophospolipid, galactoside, and sialyl glycoside residues are present in Junin virus (JV), are accessible to enzymatic digestion, and play an important role in infection. 4 major protein bands with molecular masses (Mr) 64±2, 56±2, 52±3 (mean±standard deviation, n=4) and ~12-18 kDa were consistently detected after denaturing gel electrophoresis analysis of purified attenuated JV. The 52 kDa protein showed a diffuse tail in the 52-56 kDa range and was considered to be the JV glycoprotein. By Western blotting, the 64 kDa protein bound a JV neutralizing antibody and was considered to be the viral nucleoprotein. Additional bands corresponding to larger proteins (~200, 96, 86 and 78-80 kDa in size), as well as fainter and broader bands in the 23-44 kDa region were also present in purified JV preparations. The relative resistance of virus infectivity to RNase digestion demonstrates that the genome of JV is protected from enzymatic attack. Analysis of purified JV virions by electrophoresis resolved the viral small (S) RNA and large (L) RNA species, 3636±54 bases and 7667±154 bases long, respectively (average length±range, in 4 determinations). The (S) RNA of attenuated JV appeared slightly larger than that reported for a pathogenic strain, ruling out a large sequence deletion as a reason for attenuation.
KW - biochemistry
KW - characterization
KW - proteins
KW - RNA
KW - Arenavirus
KW - Junin virus
KW - viruses
KW - Arenaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Arenavirus
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501842&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reactivity with a specific epitope of outer surface protein A predicts protection from infection with the Lyme disease spirochete, Borrelia burgdorferi.
AU - Golde, W. T.
AU - Piesman, J.
AU - Dolan, M. C.
AU - Kramer, M.
AU - Hauser, P.
AU - Lobet, Y.
AU - Capiau, C.
AU - Desmons, P.
AU - Voet, P.
AU - Dearwester, D.
AU - Frantz, J. C.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1997///
VL - 65
IS - 3
SP - 882
EP - 889
SN - 0019-9567
AD - Golde, W. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980501855. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - The response to recombinant vaccines for Lyme disease was studied to determine serum antibody levels effective in protecting against tick-transmitted infection. Data presented here demonstrate a significant correlation between antibody to an epitope on outer surface protein A (OspA) and protection against infection with Borrelia burgdorferi in dogs and mice. A competitive ELISA was developed to measure antibody to a site on OspA, defined by monoclonal antibody LA-2. Comparison of LA-2 titres against infection of dogs and mice following vaccination and challenge established a predicted value for LA-2 titres. The statistical relationship between serum antibody levels and protection was calculated by logistic regression analysis. The statistical model predicted that an LA-2 titre of 0.32 µg equivalents (eq) per ml correlated with an 80% predicted probability of protection for both mice and dogs. This value was used to classify mice and dogs as to their protected status at the time of tick exposure. The LA-2 cutoff titre (0.32 µg eq/ml) correctly classified all dogs (n = 13) and mice (n = 44) that failed to become infected. By contrast, 20 of 22 dogs and 28 of 31 mice with titres of <0.32 µg eq/ml became infected. On the basis of these results, it is concluded that an LA-2 titre is a reliable indicator of immune status for estimating immune protection following use of OspA-based vaccines for B. burgdorferi s.s.
KW - bacterial diseases
KW - ELISA
KW - immunization
KW - infection
KW - Lyme disease
KW - vaccines
KW - Borrelia burgdorferi
KW - dogs
KW - mice
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - immune sensitization
KW - lyme borreliosis
KW - ospA
KW - outer surface proteins
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501855&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Some food and drug administration perspectives of fat and fatty acids.
AU - Scarbrough, F. E.
A2 - Kris-Etherton, P. M.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1997///
VL - 65
IS - Supp5
SP - 1578S
EP - 1580S
SN - 0002-9165
AD - Scarbrough, F. E.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street SW (HFS-150), Washington, DC 20204, USA.
N1 - Accession Number: 19971405659. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 6 ref. Registry Number: 57-11-4. Subject Subsets: Human Nutrition
N2 - This article discusses the impact of the Nutrition Labeling and Education Act of 1990 on current US food labelling concerning dietary fats. Issues that must be further addressed to improve the effectiveness of the food label are also discussed and these include: health effects of n-3 and n-6 fatty acids; appropriate labelling of trans fatty acids, stearic acid and other non-cholesterol-raising saturated fatty acids; partially absorbed fats; and label claims, especially health claims for specific fatty acids and fatty acids of biotechnologically altered foods.
KW - availability
KW - composition
KW - digestibility
KW - fat
KW - fatty acids
KW - foods
KW - health
KW - labelling
KW - legislation
KW - polyenoic fatty acids
KW - regulations
KW - stearic acid
KW - trans fatty acids
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Individual fatty acids and cardiovascular disease
KW - labeling
KW - labels
KW - octadecanoic acid
KW - polyunsaturated fatty acids
KW - rules
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Food Composition and Quality (QQ500)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405659&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Upregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease components.
AU - Yamshchikov, V. F.
AU - Trent, D. W.
AU - Compans, R. W.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1997///
VL - 71
IS - 6
SP - 4364
EP - 4371
SN - 0022-538X
AD - Yamshchikov, V. F.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19970503509. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Recently, it was shown that the ability of the flavivirus NS2B-NS3 protease complex to promote efficient signalase processing of the C-prM precursor, as well as secretion of prM and E, does not appear to depend strictly on cleavage of the precursor at its Lys-Arg-Gly dibasic site by the protease. It was suggested that the association of the protease with the precursor via NS2B may be sufficient by itself for the above effects. To study the proposed association in more detail, an assay was developed in which processing at the C-prM dibasic cleavage site is abolished by Lys -> Gly conversion. Deletion mutants and chimaeras of the West Nile (WN) flavivirus NS2B protein were constructed and expressed in the context of {5′-C -> NS3243} containing either wild-type C-prM or its cleavage site mutant. All NS2B variants were able to form active protease complexes. Deletion of the carboxy-terminal cluster of hydrophobic amino acids in NS2B had no apparent effect on the formation of prM and prM-E secretion for the cassettes containing either wild-type or mutated C-prM precursor. Deletion of the amino-terminal hydrophobic cluster in NS2B did not affect prM-E secretion for the cassettes with wild-type C-prM, but abrogated prM-E secretion for the cassettes with the mutated dibasic cleavage site in C-prM. Similarly, the NS2B-NS3178 protease of Japanese encephalitis (JE) virus, when substituted for the WN virus NS2B-NS3243 protease, was able to promote prM-E secretion for the cassette with the wild-type C-prM precursor, but not with the mutated one. Replacement of the deleted amino-terminal hydrophobic cluster in the WN virus NS2B protein with an analogous JE virus sequence restored the ability of the protease to promote prM-E secretion. On the basis of these observations, roles of individual protease components in upregulation of C-prM signalase processing are discussed.
KW - arboviruses
KW - chimaeras
KW - proteinases
KW - regulation
KW - secretion
KW - viral proteins
KW - Japanese encephalitis virus
KW - West Nile virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - chimeras
KW - nonstructural proteins
KW - proteases
KW - signalases
KW - upregulation
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970503509&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast.
AU - Polo, S.
AU - Ketner, G.
AU - Levis, R.
AU - Falgout, B.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1997///
VL - 71
IS - 7
SP - 5366
EP - 5374
SN - 0022-538X
AD - Polo, S.: Laboratory of Vector-Borne Viral Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-451), Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19980500018. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The dengue virus type 2 genomic RNA was amplified by reverse transcription-PCR and cloned as 4 cDNA fragments. These 4 fragments could not be assembled into full-length cDNA in Escherichia coli. The full-length dengue virus cDNA was constructed by homologous recombination in yeast, either as part of a yeast artificial chromosome or in a yeast-E. coli shuttle vector. Full-length cDNA clones were propagated once in E. coli to prepare useful quantities of DNA. In vitro transcription of these clones produced full-length RNA transcripts. Introduction of these transcripts into LLC-MK2 cells produced typical dengue infection, as judged by cytopathic effects and indirect immunofluorescence. Infectivity was sensitive to RNase digestion and was dependent on the presence of cap analogue in the transcription reaction mixture. Virus in the medium was passaged on C6-36 mosquito cells to produce stocks, and these stocks had titres and plaque morphologies similar to those of the parental dengue virus type 2. Intracellular dengue virus RNA from cells infected with transcript-derived virus contained an introduced BstEII site, proving that infectivity was derived from RNA transcripts and not from contamination with parental dengue virus. Transcript-derived virus was comparable to dengue virus type 2 for growth and protein expression in tissue culture cells. Sequence analysis of the dengue virus cDNA in one full-length clone revealed only one unexpected silent mutation. By using yeast technology, it will be easy to introduce specific mutations into the dengue virus cDNA, allowing analysis of the virus phenotype in cells transfected with mutant transcripts.
KW - arboviruses
KW - clones
KW - complementary DNA
KW - infectivity
KW - molecular genetics
KW - yeasts
KW - dengue 2 virus
KW - dengue virus
KW - Escherichia coli
KW - fungi
KW - eukaryotes
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - arthropod-borne viruses
KW - bacterium
KW - biochemical genetics
KW - cDNA
KW - E. coli
KW - fungus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980500018&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes.
AU - Lee, S.
AU - Goldstein, H.
AU - Baseler, M.
AU - Adelsberger, J.
AU - Golding, H.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1997///
VL - 71
IS - 9
SP - 6671
EP - 6676
SN - 0022-538X
AD - Lee, S.: Laboratory of Retrovirus Research, Divison of Viral Products, CBER, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972008514. Publication Type: Journal Article. Language: English. Number of References: 32 ref.
N2 - In this report, direct evidence is provided that the most mature CD8+ thymocytes contain a population infected with HIV-1 wherein viral mRNA transcription occurs. Because CD3hi thymocytes from an uninfected SCID-hu thymus were not infectable by coculture with HIV-1-infected CD4+ thymocytes, this study suggests that infection of CD8+ thymocytes occurs during earlier stages of intrathymic T-cell development.
KW - CD8+ lymphocytes
KW - messenger RNA
KW - microbiology
KW - pathogenesis
KW - T lymphocytes
KW - thymocytes
KW - transcription
KW - tropisms
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - CD8+ cells
KW - DNA transcription
KW - human immunodeficiency virus type 1
KW - mRNA
KW - T cells
KW - t3 cells
KW - T8 lymphocytes
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax1.
AU - Cowan, E. P.
AU - Alexander, R. K.
AU - Daniel, S.
AU - Kashanchi, F.
AU - Brady, J. N.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1997///
VL - 71
IS - 9
SP - 6982
EP - 6989
SN - 0022-538X
AD - Cowan, E. P.: Division of Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-320, Rockville, MD 20852, USA.
N1 - Accession Number: 19972008523. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 308079-78-9.
N2 - These results provide the first experimental evidence that neuronal cells are sensitive to HTLV-I Tax11 as an extracellular cytokine, with a potential role in the pathology of HTLV-I-associated/tropical spastic paraparesis.
KW - genomes
KW - microbiology
KW - T lymphocytes
KW - tumour necrosis factor
KW - Deltaretrovirus
KW - human T-cell lymphotropic virus
KW - human T-cell lymphotropic virus type I
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Deltaretrovirus
KW - Human T-cell lymphotropic virus
KW - cachectin
KW - cachexin
KW - genomic structure
KW - HTLV-BLV group
KW - other microorganisms
KW - T cells
KW - tumor necrosis factor
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972008523&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The physiologic, neurologic, and behavioral effects of caloric restriction related to aging, disease, and environmental factors.
AU - Duffy, P. H.
AU - Leakey, J. E. A.
AU - Pipkin, J. L.
AU - Turturro, A.
AU - Hart, R. W.
A2 - Amr, M. M.
A2 - Johnson, B. L.
A2 - Williams-Johnson, M.
A2 - Harben, K. L.
JO - Environmental Research (New York)
JF - Environmental Research (New York)
Y1 - 1997///
VL - 73
IS - 1/2
SP - 242
EP - 248
SN - 0013-9351
AD - Duffy, P. H.: Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19981401912. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition
N2 - Male and female Fischer 344 rats and B6C3F1 hybrid mice were raised in a pathogen free environment at 23°C, and were conditioned to a 12 h light and 12 h dark cycle. Rats and mice were divided into 2 groups: a control group fed ad libitum (AL), and an energy restricted (ER) group receiving 60% of the average AL consumption. ER rats and mice were fed in 2 regimes: 5 h after 'lights on', or 5 h after 'lights off'. Total feeding time per day was higher in AL rats and mice than in ER rats and mice, but total water consumption was the same for both groups, meaning that water consumption/g of tissue was higher in ER than AL rats and mice. Average daily motor activity was higher in the ER group than the AL group. Average daily body temperature was significantly lower in the ER group than the AL group. Respiratory quotient data suggested that ER rats and mice rapidly depleted their carbohydrate reserves a few hours after consuming food rations and survive on fat metabolism until food becomes available again. Acute ER studies were undertaken to determine behavioural and physiological effects triggered by rapid shift in food intake. Mice were fed a double ration on day 1 followed by fasting on day 2 (alternate-day feeding). The onset of acute ER was characterized by lower body temperatures and level of metabolic output, and a higher level of fatty acid metabolism. In mice conditioned to chronic ER and rapidly switched to AL feeding, metabolism, temperature and activity returned to near normal levels immediately after food consumption was increased.
KW - behaviour
KW - body temperature
KW - carbohydrate metabolism
KW - energy deprivation
KW - fatty acids
KW - food intake
KW - lipid metabolism
KW - metabolism
KW - physical activity
KW - physiology
KW - respiratory quotient
KW - starvation
KW - water intake
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - fat metabolism
KW - neurobehavioural methods and effects in occupational and environmental health
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981401912&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spectral confirmation of trans monounsaturated C18 fatty acid positional isomers.
AU - Mossoba, M. M.
AU - McDonald, R. E.
AU - Roach, J. A. G.
AU - Fingerhut, D. D.
AU - Yurawecz, M. P.
AU - Sehat, N.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 1997///
VL - 74
IS - 2
SP - 125
EP - 130
SN - 0003-021X
AD - Mossoba, M. M.: Office of General Scientific Support, Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration, (FDA), Washington, DC 20204, USA.
N1 - Accession Number: 19971405229. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 112-80-1, 8001-22-7. Subject Subsets: Human Nutrition; Soyabeans
N2 - The trans octadecenoic acid methyl ester isomers were obtained from a partially hydrogenated soyabean oil sample and isolated by silver-ion HPLC. The double bond configuration was confirmed to be trans by using gas chromatography-direct deposition-Fourier transform infrared spectroscopy. The double bond positions for 9 individual trans octadecenoic acid positional isomers were confirmed by gas chromatography-electron ionization mass spectrometry after derivatization to 2-alkenyl-4,4-dimethyloxazoline. These 9 trans positional isomers were resolved on 1 of the 2 polar 100% cyanopropylpolysiloxane 100-m capillary columns, SP 2560 and Cp-Sil 88, at an isothermal temperature of 140°C. These 9 isomers were confirmed to have double bonds at carbons C-8 through C-16. The pair of trans octadecenoic acid positional isomers with double bonds at C-13 and C-14 are reported for the first time to be resolved by gas chromatography.
KW - analytical methods
KW - estimation
KW - fatty acids
KW - gas chromatography
KW - hplc
KW - hydrogenation
KW - infrared spectroscopy
KW - isomers
KW - mass spectrometry
KW - monoenoic fatty acids
KW - oleic acid
KW - soyabean oil
KW - structure
KW - trans fatty acids
KW - analytical techniques
KW - high performance liquid chromatography
KW - monounsaturated fatty acids
KW - soybean oil
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971405229&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide prioritization for a brain cancer case-control study.
AU - Sanderson, W. T.
AU - Talaska, G.
AU - Zaebst, D.
AU - Davis-King, K.
AU - Calvert, G.
JO - Environmental Research (New York)
JF - Environmental Research (New York)
Y1 - 1997///
VL - 74
IS - 2
SP - 133
EP - 144
SN - 0013-9351
AD - Sanderson, W. T.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19980502884. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Weeds
N2 - Historical pesticide usage data for Iowa, Michigan, Minnesota, Wisconsin and the USA as a whole was used to prepare prioritized prompt lists for improving interviewee recall when answering questions on exposure to pesticides in an on-going brain-cancer (glioma) case-control study of rural residents in the 4 states. The volume of pesticides usage prior to 1985, usage ranking in the 4 states and the USA as a whole and toxicological data were used to prepare the lists which contain information about 134 of the 240 herbicides, fungicides, insecticides and fumigants reported to have been used in the region.
KW - brain
KW - carcinogens
KW - disease surveys
KW - fumigants
KW - fungicides
KW - glioma
KW - herbicides
KW - human diseases
KW - insecticides
KW - neoplasms
KW - pesticides
KW - public health
KW - questionnaires
KW - risk factors
KW - rural areas
KW - surveys
KW - Iowa
KW - Michigan
KW - Minnesota
KW - USA
KW - Wisconsin
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - cancers
KW - cerebrum
KW - disease surveillance
KW - fungistats
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502884&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modelling drug residue uptake by eggs: yolks contain ampicillin residues even after drug withdrawal and nondetectability in the plasma.
AU - Donoghue, D. J.
AU - Hairston, H.
AU - Henderson, M.
AU - McDonald, M.
AU - Gaines, S.
AU - Donoghue, A. M.
JO - Poultry Science
JF - Poultry Science
Y1 - 1997///
VL - 76
IS - 3
SP - 458
EP - 462
SN - 0032-5791
AD - Donoghue, D. J.: Food and Drug Administration, Center of Veterinary Medicine, Division of Animal Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19972213737. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 69-53-4, 7177-48-2, 69-52-3. Subject Subsets: Animal Nutrition; Veterinary Science; Veterinary Science; Poultry
N2 - To examine whether: 1. preovulatory yolks may be an important storage depot for drug residues in eggs laid days to weeks after drug withdrawal; and 2. the prediction model based on the pattern of drug incorporation in developing yolks is predictive of the pattern of residues contained in the sequence of eggs laid during and after drug withdrawal, 24 hens were dosed for either 1, 2, or 3 days with ampicillin. The content and pattern of residues in laid eggs were investigated during and after dosing. Hens were bled 24 h after the final dosing, and plasma ampicillin concentrations were measured. Ampicillin was used in this study because it has an extremely short plasma half-life in laying hens that limits additional drug transfer after drug withdrawal. Ampicillin was not detectable in plasma from hens injected with ampicillin for either 1, 2 or 3 days (assay sensitivity of 0.6 ng/ml or 0.6 ppb). Hens from all 3 injection groups produced eggs containing ampicillin residues for 6 days after the last injection. These results show that drug residues are contained in eggs laid a number of days after drug withdrawal. Because plasma ampicillin was not detectable even 24 h after final dosing, most if not all, of the incurred ampicillin residues contained in eggs laid after drug withdrawal were due to incorporation and storage of drug in preovulatory yolks during the dosing period. Accounting for ampicillin's stability, this model is predictive of the pattern of residues contained in eggs. These results emphasize the importance of transfer and storage of drugs in preovulatory yolks as a significant contributing mechanism for the production of incurred drug residues in eggs.
KW - ampicillin
KW - drug residues
KW - eggs
KW - models
KW - penicillins
KW - pharmacokinetics
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - domesticated birds
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972213737&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular evolution and phylogeny of dengue-4 viruses.
AU - Lanciotti, R. S.
AU - Gubler, D. J.
AU - Trent, D. W.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 1997///
VL - 78
IS - 9
SP - 2279
EP - 2286
SN - 0022-1317
AD - Lanciotti, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502254. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Nucleotide sequences of the envelope protein genes of 19 geographically and temporally distinct dengue (DEN)-4 viruses were determined. Nucleic acid sequence comparison revealed that the identity among the DEN-4 viruses was >92%. Similarity among deduced amino acids was between 96 and 100%; in most cases identical amino acid substitutions occurred among viruses from similar geographical regions. Alignment of nucleic acid sequences followed by parsimony analysis generated phylogenetic trees, which indicated that geographically independent evolution of DEN-4 viruses had occurred. DEN-4 viruses were separated into two genetically distinct subtypes (genotypes). Genotype-1 contains viruses from the Philippines, Thailand and Sri Lanka; genotype-2 consists of viruses from Indonesia, Tahiti, the Caribbean Islands (Puerto Rico, Dominica) and Central and South America. The EMBL/GenBank/DDBJ accession numbers for the new nucleotide sequences are U18425-U18442.
KW - amino acid sequences
KW - arboviruses
KW - evolution
KW - molecular genetics
KW - nucleotide sequences
KW - phylogeny
KW - Central America
KW - Dominica
KW - Indonesia
KW - Philippines
KW - Puerto Rico
KW - South America
KW - Sri Lanka
KW - Tahiti
KW - Thailand
KW - dengue 4 virus
KW - dengue virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - America
KW - ACP Countries
KW - Caribbean Community
KW - Commonwealth of Nations
KW - Developing Countries
KW - Leeward Islands
KW - Lesser Antilles
KW - Antilles
KW - Caribbean
KW - APEC countries
KW - ASEAN Countries
KW - South East Asia
KW - Asia
KW - Greater Antilles
KW - Latin America
KW - South Asia
KW - Society Islands
KW - French Polynesia
KW - France overseas
KW - Polynesia
KW - Oceania
KW - Pacific Islands
KW - arthropod-borne viruses
KW - biochemical genetics
KW - Ceylon
KW - DNA sequences
KW - molecular evolution
KW - Porto Rico
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid determination of ampicillin in bovine milk by liquid chromatography with fluorescence detection.
AU - Ang, C. Y. W.
AU - Luo WenHong
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 1
SP - 25
EP - 30
SN - 1060-3271
AD - Ang, C. Y. W.: U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19970401508. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 1406-16-2. Subject Subsets: Human Nutrition; Veterinary Science; Dairy Science; Veterinary Science
N2 - A rapid and sensitive liquid chromatographic (LC) method was developed for the determination of ampicillin residues in raw bovine milk, pasteurized skim milk and pasteurized, homogenized whole milk with vitamin D. Milk samples were deproteinized with trichloroacetic acid (TCA) and acetonitrile. After centrifugation, the clear supernatant reacted with formaldehyde and TCA at 30°C for 30 min. The major fluorescent derivative of ampicillin was then determined by reversed-phase LC with fluorescence detection. Average recoveries of ampicillin fortified at 5, 10 and 20 ppb (ng/ml) were all >85% with coefficients of variation <10%. Limits of detection ranged from 0.31 to 0.51 ppb and limits of quantitation from 0.66 to 1.2 ppb. It is concluded that, after appropriate validation, this method should be suitable for rapid analysis of milk for ampicillin residues at the tolerance level of 10 ppb.
KW - ampicillin
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - chromatography
KW - detection
KW - drug residues
KW - fluorescence
KW - homogenized milk
KW - liquid chromatography
KW - milk
KW - milk hygiene
KW - pasteurized milk
KW - penicillins
KW - raw milk
KW - skim milk
KW - vitamin d
KW - analytical techniques
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970401508&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plant toxins.
AU - Betz, J. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 1
SP - 126
EP - 131
SN - 1060-3271
AD - Betz, J. M.: U.S. Food and Drug Administration, Division of Natural Products, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19972206937. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Horticultural Science
KW - contamination
KW - poisonous plants
KW - reviews
KW - toxins
KW - USA
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - plant
KW - toxic plants
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972206937&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chiral gas chromatographic determination of ephedrine-type alkaloids in dietary supplements containing Má Huáng.
AU - Betz, J. M.
AU - Gay, M. L.
AU - Mossoba, M. M.
AU - Adams, S.
AU - Portz, B. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 2
SP - 303
EP - 315
SN - 1060-3271
AD - Betz, J. M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 19970308316. Publication Type: Journal Article. Language: English. Number of References: 142 ref. Registry Number: 299-42-3, 50-98-6, 134-72-5. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Human Nutrition
N2 - Má Huáng is a traditional Chinese medicine derived from the aerial parts of several Ephedra species. These plants produce (-)-ephedrine, (+)-pseudoephedrine, (-)-norephedrine, (+)-norpseudoephedrine, (-)-N-methylephedrine, and (+)-N-methylpseudoephedrine. Racemic and (-)-ephedrine, (+)-pseudoephedrine and (±)-norephedrine (phenylpropanolamine) are used clinically in the United States and are largely synthetic in origin. Current interest in Má Huáng is spurred by reports describing a "thermogenic" (calorie burning) effect provided by mixtures of ephedrine, caffeine, and aspirin. Products providing the key thermogenic compounds from natural sources are available as dietary supplements in retail outlets. Reports of potentially unsafe levels of the alkaloids, as well as possible fortification of Má Huáng-containing products with synthetic Ephedra alkaloids, prompted the development of a chiral gas chromatographic (GC) method that allows determination of alkaloid patterns and identification of isomerically impure synthetic alkaloids. Nine products were analysed on a γ-cyclodextrin capillary GC column. Identity of the alkaloids was verified by GC-mass spectrometry (MS) and GC/matrix isolation/Fourier transform infrared spectroscopy. No synthetic isomers were found in the dietary supplements analysed. Three products contained only one of the ephedrine-type alkaloids. One product that listed Má Huáng as an ingredient contained no detectable ephedrine-type alkaloid. In products containing measurable quantities of these compounds, total alkaloid levels ranged from 0.3 to 56 mg/g.
KW - alkaloids
KW - amines
KW - analytical methods
KW - chemical composition
KW - determination
KW - ephedrine
KW - foods
KW - gas chromatography
KW - herbal drugs
KW - medicinal plants
KW - supplements
KW - USA
KW - Ephedra
KW - Ephedraceae
KW - Gnetopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - drug plants
KW - herbal medicines
KW - Ma Huang
KW - medicinal herbs
KW - officinal plants
KW - United States of America
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A sensitive method for evaluating condoms as virus barriers.
AU - Lytle, C. D.
AU - Duff, J. E.
AU - Fleharty, B.
AU - Bidinger, R. L.
AU - Cyr, W. H.
AU - Routson, L. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 2
SP - 319
EP - 324
SN - 1060-3271
AD - Lytle, C. D.: U.S. Food and Drug Administration, Office of Science and Technology, Center for Devices and Radiological Health, Rockville, MD 20857, USA.
N1 - Accession Number: 19972003712. Publication Type: Journal Article. Language: English. Number of References: 23 ref.
N2 - A standard test is needed to evaluate condoms as barriers against sexually transmitted diseases, particularly those caused by viruses (HIV and hepatitis B virus). The proposed method presented here consists of a previously published simple method using physiologic-based conditions plus improvements to increase test sensitivity and decrease confounding factors such as contamination. Limitations of the method were determined by measuring virus penetration through small, well-defined holes. The method detected penetration of 2 nl (2 × 10-5 ml) of challenge virus suspension as well as a hole of 2 µm diameter in a latex condom. The data also indicated that virus penetration of latex condoms occurred quickly, and the hole was then apparently closed or blocked.
KW - acquired immune deficiency syndrome
KW - barriers
KW - behaviour
KW - condoms
KW - disease transmission
KW - evaluation
KW - human diseases
KW - human immunodeficiency viruses
KW - methodology
KW - penetration
KW - prevention
KW - safer sex
KW - social behaviour
KW - techniques
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - AIDS
KW - behavior
KW - human immunodeficiency virus
KW - methods
KW - safe sex
KW - social behavior
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Other Control Measures (HH700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003712&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of sorbitol MacConkey and hemorrhagic coli agars for recovery of Escherichia coli O157:H7 from Brie, ice cream, and whole milk.
AU - Hammack, T. S.
AU - Feng, P.
AU - Amaguaña, R. M.
AU - June, G. A.
AU - Sherrod, P. S.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 2
SP - 335
EP - 340
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19970401800. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 50-70-4. Subject Subsets: Human Nutrition; Dairy Science
N2 - The relative efficacies of haemorrhagic coli (HC) agar and several formulations of sorbitol MacConkey (SorMac) agar with and without 0.1% (w/v) 4-methylumbelliferyl-β-D-glucuronide (MUG), in recovering unstressed and heat-stressed E. coli from Brie cheese, ice cream and whole milk were determined. Recovery of unstressed E. coli was determined quantitatively by spread-plating diluted samples onto different agars and performing plate counts. Recovery of stressed E. coli was determined qualitatively by enriching samples in modified trypticase soya broth, streaking the incubated enrichments, and isolating colonies from the agars. HC agar and the SorMac agar formulations did not differ significantly in their ability to recover unstressed E. coli from ice cream and whole milk. However, HC agar recovered significantly more unstressed E. coli from Brie cheese than did SorMac agar formulations. Bacteriological Analytical Manual and commercially-available Oxoid SorMac agar formulations made from individual ingredients, did not differ significantly in recovering unstressed E. coli from Brie cheese. The efficiency of the Oxoid SorMac agar could not be determined because of overgrowth by indigenous microflora. It is concluded that HC and SorMac agars did not differ significantly in recovering stressed E. coli from Brie cheese, ice cream and whole milk. MUG had no apparent effect on recovery of either stressed or unstressed E. coli.
KW - analytical methods
KW - Brie cheese
KW - culture media
KW - detection
KW - ice cream
KW - identification
KW - microbial contamination
KW - milk
KW - milk products
KW - recovery
KW - sorbitol
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - 4-methyllumbelliferyl-beta-D-glucuronide
KW - analytical techniques
KW - bacterium
KW - dairy products
KW - E. coli
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration Organisms (SS320) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970401800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of acriflavine and proflavine residues in channel catfish muscle.
AU - Plakas, S. M.
AU - El-Said, K. R.
AU - Jester, E. L. E.
AU - Bencsath, F. A.
AU - Hayton, W. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 3
SP - 486
EP - 490
SN - 1060-3271
AD - Plakas, S. M.: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, PO Box 158, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 19972216572. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 8048-52-0. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Veterinary Science
N2 - A liquid chromatographic (LC) method was developed for determination of acriflavine (ACR) and proflavine (PRO) residues in channel catfish muscle. Residues were extracted with acidified methanol solution, and extracts were cleaned up with C18 solid-phase extraction columns. Residue concentrations were determined on an LC cyano column, with spectrophotometric detection at 454 nm. Catfish muscle was individually fortified with ACR (purified from commercial product) and PRO at concentrations of 5, 10, 20, 40, and 80 ppb (5 replicates per level). Mean recoveries from fortified muscle at each level ranged from 86 to 95%, with relative standard deviations (RSDs) of 2.5 to 5.7%. The method was applied to incurred residues of ACR and PRO in muscle after waterborne exposure of channel catfish to commercial ACR (10 ppm total dye for 4 h). RSDs for incurred residues of ACR and PRO were in the same range as those for fortified muscle. Low residue concentrations (<1% of exposure water concentration) suggested poor absorption of ACR and PRO in catfish.
KW - acriflavine
KW - analytical methods
KW - detection
KW - drug residues
KW - laboratory methods
KW - liquid chromatography
KW - residues
KW - Ictalurus
KW - ictalurus punctatus
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictalurus
KW - analytical techniques
KW - Ictalarus punctatus
KW - laboratory techniques
KW - proflavine
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972216572&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic method for putrescine and cadaverine in canned tuna and mahimahi and fluorometric method for histamine (minor modification of AOAC official method 977.13): collaborative study.
AU - Rogers, P. L.
AU - Staruszkiewicz, W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 3
SP - 591
EP - 602
SN - 1060-3271
AD - Rogers, P. L.: U.S. Food and Drug Administration, Office of Seafood, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971410006. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 462-94-2, 51-45-6, 110-60-1. Subject Subsets: Human Nutrition
N2 - A collaborative study was conducted to test a modification to the AOAC fluorometric method for histamine that substitutes 75% methanol as the extracting solvent. All other steps remain unchanged. The extracts prepared with 75% methanol were also used to test a gas chromatographic (GC) method for determination of putrescine and cadaverine in seafood. In the GC method, the extracted diamines are converted to fluorinated derivatives, the reaction mixtures are passed through solid-phase extraction columns, and the derivatives are quantitated by electron capture GC after separation on an OV-225 column. 14 laboratories using the GC method for putrescine and cadaverine and 16 laboratories using the fluorometric method for histamine analysed 14 canned tuna and raw mahimahi (including blind duplicates and a spike) containing 0.2-2.6 mg/kg putrescine, 0.6-9.1 mg/kg cadaverine, and 0.6-154 mg/kg histamine. At the 5 mg/kg level, recoveries ranged from 71 to 102% for putrescine and 77 to 112% for cadaverine; the respective repeatability relative standard deviations (RSDr) were 5.2 and 15%, and the respective reproducibility relative standard deviations (RSDR) were 8.8 and 18%. At the 50 mg/kg level, histamine recoveries ranged from 84 to 125%, RSDr was 3.6%, and RSDR was 9.4%. The GC method for determination of putrescine in canned tuna and cadaverine in canned tuna and mahimahi has been adopted first action by AOAC INTERNATIONAL, and the AOAC Official Method 977.13, Histamine in Seafood, Fluorometric Method, has been modified.
KW - analytical methods
KW - biogenic amines
KW - cadaverine
KW - canned fish
KW - chromatography
KW - fish
KW - gas chromatography
KW - histamine
KW - putrescine
KW - tuna
KW - Scombridae
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - 1,5-pentanediamine
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410006&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid liquid chromatographic method to distinguish wild salmon from aquacultured salmon fed synthetic astaxanthin.
AU - Turujman, S. A.
AU - Wamer, W. G.
AU - Wei RongRong
AU - Albert, R. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 3
SP - 622
EP - 632
SN - 1060-3271
AD - Turujman, S. A.: U.S. Food and Drug Administration, Office of Cosmetics and Colors, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971410007. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 472-61-7. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - A liquid chromatographic (LC) method was developed to identify the synthetic form of the colour additive astaxanthin in salmon, based on differences in the relative ratios of the configurational isomers of astaxanthin. The distributions of configurational isomers of astaxanthin in the flesh of wild Atlantic and wild Pacific salmon are similar, but significantly different from that in aquacultured salmon. Astaxanthin is extracted from the flesh of salmon, passed through a silica gel Sep-Pak cartridge, and analysed directly by LC on a Pirkle covalent L-leucine column. No derivatization of the astaxanthin is required-an important advantage of this approach, which is a modification of the authors' previously described method. This method can be used to distinguish between aquacultured and wild salmon. The method has general applicability and can also be used to identify astaxanthins derived from other sources such as Phaffia yeast and Haematococcus pluvialis algae.
KW - analytical methods
KW - aquaculture
KW - astaxanthin
KW - chromatography
KW - fish
KW - liquid chromatography
KW - xanthophylls
KW - atlantic salmon
KW - fishes
KW - salmon
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - diadromous fishes
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - analytical techniques
KW - Salmo salar
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Additives (RR130)
KW - Animal Husbandry (General) (LL100) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971410007&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extraction and cleanup of organochlorine and organophosphorus pesticide residues in fats by supercritical fluid techniques.
AU - Hopper, M. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 3
SP - 639
EP - 646
SN - 1060-3271
AD - Hopper, M. L.: U.S. Food and Drug Administration, Total Diet and Pesticide Research Center, PO Box 15905, Lenexa, KS 66285-5905, USA.
N1 - Accession Number: 19970402876. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Dairy Science; Human Nutrition; Medical & Veterinary Entomology; Weeds; Agricultural Entomology
N2 - A supercritical fluid extraction and clean-up procedure was developed for separating organochlorine and organophosphorus pesticides from fats (including butter, vegetable oils, fish sticks, and meat products). Supercritical carbon dioxide modified with 3% (v/v) acetonitrile was used to extract the pesticides at 60°C and to separate the pesticides from the fats at 4000 psi and 95°C on an in-line C1 silica-based column. The extraction and clean-up procedure gave good recoveries for 43 of the 62 non-polar to moderately-polar organochlorine and organophosphorus pesticides from fats, whereas 49 were recovered through conventional Florisil column clean-up before quantification. This procedure can extract and clean up pesticide residues from 0.65 g animal-based fat and 1.0 g vegetable oils. Co-eluted residues in the pesticide fraction ranged from 2.5 mg for butter to 0.8 mg for maize oil. Results for samples analysed with this integrated extraction clean-up procedure were reproducible and comparable with results obtained with the current Total Diet Study methodology.
KW - agricultural entomology
KW - analytical methods
KW - butter
KW - contamination
KW - extraction
KW - fats
KW - fish products
KW - foods
KW - herbicide residues
KW - herbicides
KW - maize oil
KW - meat products
KW - nontarget effects
KW - organochlorine insecticides
KW - organochlorine pesticides
KW - organophosphorus herbicides
KW - organophosphorus insecticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - plant oils
KW - residues
KW - techniques
KW - Usa
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - corn oil
KW - organic chlorine pesticides
KW - United States of America
KW - vegetable oils
KW - weedicides
KW - weedkillers
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970402876&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sulfonamides in edible salmon tissue by liquid chromatography with postcolumn derivatization and fluorescence detection.
AU - Gehring, T. A.
AU - Rushing, L. G.
AU - Thompson, H. C., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 4
SP - 751
EP - 755
SN - 1060-3271
AD - Gehring, T. A.: U.S. Food and Drug Administration, National Center for Toxicological Research, Office of Research, Division of Chemistry, Jefferson, AR 72079, USA.
N1 - Accession Number: 19982203586. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Veterinary Science; Veterinary Science; Human Nutrition
N2 - Fourteen sulfonamides (sulfanilamide, sulfadiazine, sulfathiazole, sulfapyridine, sulfamerazine, sulfamethazine [sulfadimidine], sulfamethizole, sulfamethoxypyridazine, sulfachlorpyridazine, sulfamonomethoxine, sulfadoxine, sulfamethoxazole, sulfadimethoxine, and sulfaquinoxaline), residues of which could be found in aquacultured species, were separated in <25 min by reversed-phase (C18) liquid chromatography (LC) with gradient elution. Analytes were extracted from edible salmon tissue (muscle and adhering skin) with acetonitrile-2% aqueous acetic acid, isolated with 2 liquid-liquid partitionings, and derivatized with fluorescamine after eluting from the column. The derivatives were detected by fluorescence. Recoveries from coho salmon (Oncorhynchus kisutch) fortified with sulfonamides at 5, 10, and 20 ng/g tissue averaged 79.7±7.3, 84.6±7.7, and 88.2±7.1%, respectively. Limits of quantitation were 5 ng/g tissue, for sulfanilamide, sulfamethoxypyridazine, and sulfaquinoxaline and 1 ng/g tissue for the remaining sulfonamides.
KW - analytical methods
KW - antibacterial agents
KW - detection
KW - determination
KW - drug residues
KW - fish
KW - fluorescence
KW - liquid chromatography
KW - sulfonamides
KW - fishes
KW - Oncorhynchus kisutch
KW - salmon
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Oncorhynchus
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - analytical techniques
KW - sulphonamides
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982203586&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extension of dry ash atomic absorption and spectrophotometric methods to determination of minerals and phosphorus in soy-based, whey-based, and enteral formulae (modification of AOAC Official Methods 985.35 and 986.24): collaborative study.
AU - Cook, K. K.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 4
SP - 834
EP - 844
SN - 1060-3271
AD - Cook, K. K.: US Food and Drug Administration, Office of Food Labeling, Division of Science and Applied Technology, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19970403689. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7440-70-2, 7440-50-8, 7439-89-6, 7439-95-4, 7439-96-5, 7723-14-0, 7440-09-7, 7440-23-5, 7440-66-6. Subject Subsets: Human Nutrition; Dairy Science
N2 - Eight laboratories participated in a collaborative study of AOAC Official Method 985.35 (Minerals in Ready-to-Feed Milk-Based Infant Formula and Pet Foods, Atomic Absorption Spectrophotometric Method); and 7 laboratories participated in a study of AOAC Official Method 986.24 (Phosphorus in Milk-Based Infant Formula, Spectrophotometric Method), to extend these methods to infant formulae (other than milk-based) and enteral products. Three ready-to-feed soya-based formulae, 2 dried soya-based formulae a whey-based formula and a casein-based enteral formula were studied. Soya-based formulae containing nearly identical concentrations of particular elements were matched, and an application of the Youden 'closely matched pair' approach was used to estimate repeatability parameters. Average reproducibility values were as follows: calcium, 9.3%; copper, 9.7%; iron, 5.5%; potassium, 4.0%; magnesium, 5.2%; manganese, 10.6%; sodium, 4.7%; phosphorus, 10.5%; and zinc, 7.3%. At similar analyte concentrations, the between-laboratory variabilities compared well with those reported for the official methods. Most repeatability and reproducibility parameters compared well with the original collaborative study. AOAC Official Methods 985.35 and 986.24 have been modified to extend their applicability to infant formulae (other than milk-based) and enteral products.
KW - analytical methods
KW - atomic absorption spectrophotometry
KW - calcium
KW - copper
KW - determination
KW - enteral feeding
KW - infant formulae
KW - iron
KW - magnesium
KW - manganese
KW - milk products
KW - minerals
KW - phosphorus
KW - potassium
KW - sodium
KW - soya protein
KW - spectrophotometry
KW - whey protein
KW - zinc
KW - Usa
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - dairy products
KW - infant formula
KW - infant formulas
KW - Mn
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970403689&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sodium in biological materials by instrumental neutron activation analysis.
AU - Cunningham, W. C.
AU - Capar, S. G.
AU - Anderson, D. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 4
SP - 871
EP - 882
SN - 1060-3271
AD - Cunningham, W. C.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Elemental Research Branch (HFS-338), Washington, DC 20204, USA.
N1 - Accession Number: 19971411463. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 7440-23-5. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The method includes common procedures from the numerous options available to this historically nonformalized analytical technique. The number of procedural options is restricted to minimize the method's complexity, yet the method is still applicable to a variety of neutron activation facilities. High accuracy and precision are achieved by placing bounds on allowed uncertainty at critical stages of the analysis. Analytical results from the USA Food and Drug Administration laboratory and 4 other laboratories demonstrate the method's performance.
KW - analytical methods
KW - minerals
KW - neutron activation analysis
KW - sodium
KW - analytical techniques
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Food Composition and Quality (QQ500)
KW - Feed Composition and Quality (RR300)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971411463&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monitoring of domestic and imported apples and rice by the U.S. Food and Drug Administration Pesticide Program.
AU - Roy, R. R.
AU - Wilson, P.
AU - Laski, R. R.
AU - Roberts, J. I.
AU - Weishaar, J. A.
AU - Bong, R. L.
AU - Yess, N. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 4
SP - 883
EP - 894
SN - 1060-3271
AD - Roy, R. R.: U.S. Food and Drug Administration, Office of Field Programs, Division of Field Program Planning and Evaluation, Washington, DC 20204, USA.
N1 - Accession Number: 19971110155. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 17804-35-2, 121-75-5. Subject Subsets: Horticultural Science; Agricultural Entomology; Plant Pathology; Human Nutrition; Rice; Postharvest Research
N2 - In 1993-94, the U.S. Food and Drug Administration (FDA) conducted a statistically based study of pesticide residues in domestic and imported fresh apples and processed rice. For apples, 769 domestic and 1062 imported samples were collected and analysed. Of these, 85% of the domestic and 86% of the imported samples had detectable residues. Benomyl, a widely-used fungicide, was found with greatest frequency in domestic apples, while diphenylamine was found most often in imported apples. One domestic and 4 imported samples contained violative residues of pesticides for which there are no U.S. tolerances on apples. The statistically weighted (by domestic packer throughput or import shipment size) violation rates for domestic and imported apples were 0.30% (0.13 unweighted) and 0.41% (0.38 unweighted), respectively. For rice, 598 domestic and 612 imported samples were collected and analysed. Of these, 56% of the domestic and 12% of the imported samples had detectable residues. Malathion had the greatest frequency of occurrence in both groups of rice. Eight domestic and 9 imported samples were violative, all as a result of use of pesticides for which there are no U.S. tolerances on rice. The statistically weighted violation rates for domestic and imported rice were 0.43% (1.3 unweighted) and 1.1% (1.5 unweighted), respectively. Results of the statistically based study show that, as in FDA's regulatory monitoring, the levels of most pesticide residues found in these 2 commodities are generally well below U.S. tolerances, and few violative residues are found.
KW - agricultural entomology
KW - apples
KW - benomyl
KW - contamination
KW - foods
KW - fungicides
KW - imports
KW - insecticide residues
KW - malathion
KW - nontarget effects
KW - pesticide residues
KW - pesticides
KW - plant pathology
KW - rice
KW - stored products
KW - USA
KW - Malus
KW - Oryza
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fundazol
KW - fungistats
KW - paddy
KW - phytopathology
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971110155&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of pirlimycin residue in milk by liquid chromatographic analysis of the 9-fluorenylmethyl chloroformate derivative.
AU - Heller, D. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 5
SP - 975
EP - 981
SN - 1060-3271
AD - Heller, D. N.: U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 19980401011. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Veterinary Science; Dairy Science; Human Nutrition; Veterinary Science
N2 - A procedure to determine pirlimycin residues in milk was developed. Pirlimycin was extracted from milk after protein precipitation and 2 stages of liquid-liquid partitioning. The extract was evaporated to dryness, redissolved in dilute base and derivatized with 9-fluorenylmethyl chloroformate (Fmoc) to impart a chromophore for ultraviolet (UV) detection. The derivatized extract was analysed by reversed-phase liquid chromatography (LC). Pirlimycin concentration was calculated from the peak height of the extract by using a linear regression standard curve prepared from a series of derivatized standards. The validity of the procedure in the range of the regulatory tolerance (0.4 ppm) was determined by replicate analysis of control, fortified control and residue-incurred milk. Average recoveries at 0.2, 0.4 and 0.8 ppm were 91, 88 and 87%, respectively, and coefficients of variation were 5, 4 and 1%, respectively. Overall recovery for all samples was 89%, with 4% coefficient of variation. Linear regression analysis of LC/UV results vs. results from a previously published LC/mass spectrometric assay gave a slope of 0.95, with a correlation coefficient of 0.98.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - cows
KW - determination
KW - drug residues
KW - liquid chromatography
KW - mastitis
KW - milk
KW - milk hygiene
KW - treatment
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - pirlimycin
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401011&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of four fluoroquinolones in milk by liquid chromatography.
AU - Roybal, J. E.
AU - Pfenning, A. P.
AU - Turnipseed, S. B.
AU - Walker, C. C.
AU - Hurlbut, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 5
SP - 982
EP - 987
SN - 1060-3271
AD - Roybal, J. E.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19980401012. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 85721-33-1, 91296-86-5, 98106-17-3, 93106-60-6. Subject Subsets: Veterinary Science; Dairy Science; Human Nutrition; Veterinary Science
N2 - A liquid chromatographic (LC) method with fluorescence detection was developed for the analysis of 4 fluoroquinolones; enrofloxacin, ciprofloxacin, sarafloxacin and difloxacin in milk. The procedure consisted of extraction of milk with acidified ethanol, isolation and retention on a cation exchange solid-phase extraction column, elution with basic methanol and LC analysis with fluorescence detection. LC analysis was performed by isocratic elution using an acetonitrile-2% acetic acid (15 + 85) mobile phase and an Inertsil phenyl column with fluorescence detection at excitation and emission wavelengths of 278 and 450 nm, respectively. A target level of 10 ppb for each of the 4 fluoroquinolones was established for this method. Average recovery from fortified raw milk samples (5-100 ppb each) based on a 5-point standard curve calculation was 70-90%, with relative standard deviations of <15%.
KW - analytical methods
KW - antibacterial agents
KW - ciprofloxacin
KW - determination
KW - difloxacin
KW - drug residues
KW - enrofloxacin
KW - liquid chromatography
KW - milk
KW - quinolones
KW - analytical techniques
KW - sarafloxacin
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980401012&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of residues of alachlor and related herbicides in crops by liquid chromatography with electrochemical detection.
AU - Nortrup, D. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 5
SP - 1104
EP - 1110
SN - 1060-3271
AD - Nortrup, D. A.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Pesticides and Industrial Chemicals, Methods Research Branch, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19982300411. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 34256-82-1, 15972-60-8, 23184-66-9. Subject Subsets: Weeds
N2 - A method is described for determining residues of 3 acetamide herbicides - alachlor, acetochlor and butachlor - by liquid chromatography (LC). Currently no published method determines metabolites from all 3 herbicides in crops. Strong-base hydrolysis after extraction of a test portion with water-acetonitrile results in the formation of 2,6-diethylaniline (DEA) and 2-(1-hydroxyethyl)-6-ethylaniline from alachlor metabolites, 2-ethyl-6-methylaniline and 2-(1-hydroxyethyl)-6-methylaniline from acetochlor metabolites and DEA from butachlor. The anilines are isolated by steam distillation, partitioned with Supelclean ENVI-Chrom P solid-phase extraction columns, and methylated prior to LC analysis. The limit of quantitation of aniline moieties is about 0.01 ppm. Recoveries of 0.01-0.40 ppm aniline moieties are generally 74-103%, with relative standard deviations of 2.2 to 14.0%.
KW - acetochlor
KW - alachlor
KW - analysis
KW - butachlor
KW - crops
KW - detection
KW - determination
KW - extraction
KW - herbicide residues
KW - herbicides
KW - liquid chromatography
KW - metabolites
KW - residues
KW - weedicides
KW - weedkillers
KW - Techniques and Methodology (ZZ900)
KW - Pesticides and Drugs (General) (HH400)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982300411&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival and detection of Shigella flexneri in vegetables and commercially prepared salads.
AU - Rafii, F.
AU - Lunsford, P.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1997///
VL - 80
IS - 6
SP - 1191
EP - 1197
SN - 1060-3271
AD - Rafii, F.: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981405774. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Horticultural Science; Human Nutrition; Potatoes
N2 - The normal bacterial microflora of 4 commercially prepared salads (coleslaw, crab salad, carrot salad, and potato salad) and 3 vegetables (green pepper, onion, and cabbage), obtained from supermarkets in Jefferson, USA, were evaluated. 28 species of bacteria, including potential pathogens, were isolated. The foods were artificially inoculated with an avirulent mutant strain of Shigella flexneri 5 (pHS1059) to develop a method for the rapid detection of Shigella spp. Bacteria were separated from insoluble and particulate salad ingredients by filtration through shark skin filter paper and by low speed centrifugation. S. flexneri survived at 4°C in all salads for at least 11 days and up to 20 days in crab salad. The polymerase chain reaction (PCR), using primers for amplification of a 118-base pair DNA fragment from the virulence-associated spa region, present in all Shigella spp., was used to detect S. flexneri in filtrates from salads inoculated with S. flexneri 5 (pHS1059). DNA was amplified from all of the artificially contaminated salads and vegetables except green pepper. After 3-5 days of storage, the PCR also amplified S. flexneri DNA from salads that had been enriched with nutrients to increase the number of bacteria. Green peppers contained a PCR inhibitory substance that was attenuated by dilution and enrichment before the PCR. No amplification of DNA was observed in foods to which S. flexneri had not been added.
KW - analytical methods
KW - cabbages
KW - chillies
KW - detection
KW - microbial contamination
KW - onions
KW - polymerase chain reaction
KW - potatoes
KW - prepared foods
KW - salads
KW - survival
KW - vegetables
KW - Arkansas
KW - USA
KW - Allium
KW - Brassica oleracea var. capitata
KW - Capsicum frutescens
KW - Shigella
KW - Shigella flexneri
KW - Solanum tuberosum
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Brassica oleracea
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - Capsicum
KW - Solanaceae
KW - Solanales
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Shigella
KW - Solanum
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West South Central States of USA
KW - analytical techniques
KW - bacterium
KW - Capparales
KW - PCR
KW - prepared dishes
KW - United States of America
KW - vegetable crops
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981405774&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infection of Anopheles freeborni mosquitoes on New World monkeys infected with the Uganda I/CDC strain of Plasmodium malariae.
AU - Collins, W. E.
AU - Richardson, B. B.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Galland, G. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1997///
VL - 83
IS - 6
SP - 1099
EP - 1103
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980505340. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - Anopheles freeborni fed during 85 primary and 26 recrudescent infections of the Uganda I/CDC strain of Plasmodium malariae in Saimiri and Aotus monkeys (Saimiri boliviensis, Aotus nancymai, A. lemurinus griseimembra and A. azarae boliviensis) were examined for the presence of oocysts. Of these, 42 primary and 14 recrudescent infections were infective. Mosquitoes were more frequently infected when fed upon A. lemurinus griseimembra animals. A retrospective examination indicated the greatest mosquito infectivity occurred before the maximum parasite count. Mosquito infection was highest 4, 5 and 6 days after the parasite count exceeded 1000/µl. Overall, 98 of 304 positive lots (32.2%) had ≥50% of the individual mosquitoes infected. In addition, lots of A. freeborni were fed through membranes on the blood of 34 monkeys. During the days following the parasite count reaching ≥1000/µl, feedings on the animals resulted in lower levels of infection than membrane feeding, thus extending the period of mosquito infection.
KW - disease vectors
KW - experimental infection
KW - infectivity
KW - parasites
KW - Anopheles freeborni
KW - Aotus
KW - Aotus azarae
KW - Aotus lemurinus
KW - Aotus nancymai
KW - Culicidae
KW - Diptera
KW - monkeys
KW - Plasmodium malariae
KW - protozoa
KW - Saimiri
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - Aotus azarae boliviensis
KW - Aotus azarai
KW - Aotus lemurinus griseimembra
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980505340&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation of a strain of Plasmodium falciparum from a Montagnard refugee to Aotus monkeys.
AU - Collins, W. E.
AU - Grady, K. K.
AU - Millet, P.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Galland, G. G.
AU - Richardson, B. B.
AU - Yang ChunFu
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1997///
VL - 83
IS - 6
SP - 1174
EP - 1177
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980806619. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - A strain of Plasmodium falciparum isolated from a Vietnamese Montagnard refugee was shown to produce large numbers of gametocytes in culture. Attempts were made to establish this strain in various Aotus species via trophozoite and sporozoite inoculation. The Montagnard S-1 strain was readily adapted to A. lemurinus griseimembra via trophozoite inoculation. Other species of Aotus failed to support the development of high density parasitaemia. None of 12 attempts to transmit the infection via sporozoites from Anopheles freeborni or A. dirus was successful. However, developing exoerythrocytic stages were demonstrated in hepatocytes of an Aotus lemurinus griseimembra.
KW - adaptation
KW - disease transmission
KW - experimental infection
KW - parasites
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Aotus
KW - Aotus lemurinus
KW - Culicidae
KW - Diptera
KW - Plasmodium falciparum
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Aotus
KW - Aotus lemurinus griseimembra
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806619&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection.
AU - Nakazawa, M.
AU - Fantappie, M. R.
AU - Freeman, G. L., Jr.
AU - Eloi-Santos, S.
AU - Olsen, N. J.
AU - Kovacs, W. J.
AU - Secor, W. E.
AU - Colley, D. G.
JO - Experimental Parasitology
JF - Experimental Parasitology
Y1 - 1997///
VL - 85
IS - 3
SP - 233
EP - 240
SN - 0014-4894
AD - Nakazawa, M.: Division of Parasitic Disease, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19980802598. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8, 15262-86-9. Subject Subsets: Helminthology
N2 - Testosterone levels were manipulated in groups of CBA/J mice which were exposed to infection with Schistosoma mansoni. By 16 weeks of infection, >80% of mice with low levels of testosterone (including females and castrated males) were dead, whereas <40% of those in groups with high levels of testosterone (including testosterone-treated castrates and testosterone-treated females) were dead. The mean number of worms recovered from mice in the low testosterone groups was significantly greater than that from those in the high testosterone groups. When male mice were castrated 5 weeks after infection, no significant differences in host survival occurred. Female mice showed reduced worm burdens if testosterone was given 10 days before infection, but not if it was given 10 days or 5 weeks after infection.
KW - disease resistance
KW - experimental infections
KW - helminths
KW - human diseases
KW - laboratory animals
KW - mortality
KW - parasites
KW - schistosomiasis
KW - susceptibility
KW - testosterone
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - death rate
KW - parasitic worms
KW - resistance to disease
KW - schistosomosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980802598&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cervical and breast cancer screening rates in Sioux Indian women.
AU - Mahmoodian, S.
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 1997///
VL - 90
IS - 3
SP - 316
EP - 320
SN - 0038-4348
AD - Mahmoodian, S.: Epidemiology Program, Aberdeen Area Indian Health Service, Rapid City, SD, USA.
N1 - Accession Number: 19972009373. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - Data on cervical and breast cancer screening were collected from 100 diabetic and 100 randomly selected Sioux Indian women from the USA, aged 50-69 years in 1994. Patients with diabetes were selected to better evaluate the effects of patient acceptance of screening tests, since these patients were believed to be more motivated to have preventive care, although the results of this study showed no observable differences. Among the patients with diabetes, 33% had at least one cervical smear and 45% had a mammogram. For patients without diabetes, the rates were 32% and 42%, respectively. The number of patient visits to physicians during the 12-month study period averaged 7 for patients with diabetes and 4 for randomized patients. It is concluded that missed opportunity and limited access to cancer screening are the main reasons for a higher rate of cervical cancer mortality among Native American women in the USA.
KW - American Indians
KW - breast
KW - breast cancer
KW - cervical cancer
KW - cervix
KW - diabetes
KW - ethnic groups
KW - health services
KW - human diseases
KW - neoplasms
KW - screening
KW - women
KW - North America
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - breasts
KW - cancer sites
KW - cancers
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Services (UU350)
KW - Women (UU500)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009373&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - Gen
ID - 9999-27707-000
AN - 9999-27707-000
AU - Knox, Howard A.
T1 - Cube Imitation Test
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1914///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: No
N1 - Accession Number: 9999-27707-000. Other Names: Knox's Cube Test; Cube Imitation Test; Cube Test. Partial author list: First Author & Affiliation: Knox, Howard A.; United States Public Health Service, Ellis Island, New York, United States. Release Date: 20140512. Correction Date: 20160111. Instrument Type: Test. Test Location: Figure 2, Page 742. Language: English. Constructs: General Intelligence; Classification: Cognitive Processes, Memory, and Decision Making (5400). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360).
N2 - Administration Method: Physical Object
AB - Purpose: The purpose of the Cube Imitation Test is to provide a performance test for use in the mental classification of immigrants.
AB - Description: The Cube Imitation Test (Knox, 1914) is a performance test developed for use in the mental classification of immigrants. The subject is seated at a table opposite the examiner with the test board placed between them. The examiner taps the blocks in a certain order, maintaining a constant speed of tapping by means of the silent pendulum. The subject is then instructed to tap the blocks in the identical order. More specifically, 4 1-inch cubes, 4 inches apart, are fastened to a piece of thin boarding. The movements and tapping are done with a smaller cube (movements are slow and deliberate). The operator moves the cube from left to right facing the subject, and after completing each movement, the latter is asked to do likewise. Line A is tried first, then B, and so on to E. Three trials are given if necessary on lines A, B, C and D, and five trials if needed on line E. The different lines of the cube test are given to different age groups. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Cube Imitation Test
KW - Test Development
KW - General Intelligence
KW - Standardization
KW - Cognitive Processing
KW - Intelligence
KW - Internal Consistency
KW - Nonverbal Test
KW - Performance Test
KW - Test-Retest Reliability
KW - Visuospatial Memory
KW - Visuospatial Processing
U5 - Cube Imitation Test [Test Development]A Scale, based on the Work at Ellis Island, for Estimating Mental Defect. (AN: 1914-10065-008 from PsycINFO) Knox, H.; 1914. Source: J. of Amer. Med. Assoc. 62; Administration: Physical Object Population: Human; Sample: Immigrants; Location: United States Keywords: Cube Imitation Test; Test Development; General Intelligence; Subjects: Intelligence Measures; Test Construction;
U5 - Cube Imitation Test [Test Review]The standardization of Knox's Cube Test. (AN: 1926-03306-001 from PsycINFO) Pintner, Rudolf; Sep, 1915. Source: Psychological Review. 22(5), Psychological Review Company, US; Sep, 1915; Administration: Physical Object Population: Human; Male; Female; Sample: Normal and Feeble-Minded Individuals Keywords: Cube Imitation Test; Standardization; General Intelligence; Subjects: Intelligence Measures; Test Standardization;
U5 - Cube Imitation Test [Test Review]Knox's cube imitation test: A historical review and an experimental analysis. (AN: 2005-15592-008 from PsycINFO) Richardson, John T. E.; Nov, 2005. Source: Brain and Cognition. 59(2), Elsevier Science, Netherlands; Nov, 2005; Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Population: Human; Male; Female; Location: United Kingdom; Sample: Undergraduate Students Keywords: Cognitive Processing; Cube Imitation Test; Intelligence; Internal Consistency; Nonverbal Test; Performance Test; Test-Retest Reliability; Visuospatial Memory; Visuospatial Processing; Subjects: Cognitive Processes; Intelligence; Intelligence Measures; Nonverbal Ability; Performance Tests; Test Reliability; Visuospatial Memory;
DO - 10.1037/t27707-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-27707-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 2005-13860-008
AN - 2005-13860-008
AU - Van Ness Dearborn, George
T1 - Review of Conflict and Dream.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1923/04//
VL - 18
IS - 1
SP - 98
EP - 99
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13860-008. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Van Ness Dearborn, George; U. S. Public Health Service Reserve, NY, US. Release Date: 20060327. Correction Date: 20170112. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Conflict; Dreaming; Personality. Minor Descriptor: Subconscious. Classification: Consciousness States (2380); Psychoanalytic Theory (3143). Population: Human (10). Reviewed Item: Rivers, W. H. R.; Smith, G. Elliot (Prod). Conflict and Dream=New York. Harcourt, Brace and Co., 1923. Pp. xi+195; 1923. Page Count: 2. Issue Publication Date: Apr, 1923. Copyright Statement: American Psychological Association. 1923.
AB - Reviews the book, Conflict and Dream by W. H. R. Rivers (1923). This book represents the substance of a course of lectures delivered in the Psychologic Laboratory of the University of Cambridge during the two sessions from 1920 to 1922. Smith, who writes the preface of this book, notes that it is a great misfortune that the author was not able, due to untimely death, to accomplish the difficult task of revising the manuscript, 'for the book is essentially an analysis of his own dreams and an intimate revelation of his own personality, and the manuscript was freely annotated with personal references to his friends and colleagues'. The book to a degree is a human document, since it relates and discusses several of the author's own dreams. There are ten chapters, two appendices, and a good index. Altogether, the book is a worthy member of the International Library of Psychology, Philosophy, and Scientific Method series. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - conflict
KW - dreams
KW - personality
KW - subconscious
KW - 1923
KW - Conflict
KW - Dreaming
KW - Personality
KW - Subconscious
KW - 1923
U2 - Rivers, W. H. R.; Smith, G. Elliot (Prod). (1923); Conflict and Dream; New York. Harcourt, Brace and Co., 1923. Pp. xi+195
DO - 10.1037/h0066885
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13860-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13857-008
AN - 2005-13857-008
AU - Dearborn, George Van Ness
T1 - Review of Dreads and besetting fears, including states of anxiety, their causes and cure.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1923/07//Jul-Sep, 1923
VL - 18
IS - 2
SP - 183
EP - 184
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13857-008. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George Van Ness; U. S. Public Health Service Reserve, NY, US. Release Date: 20060329. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Emotional Control; Fear; Phobias. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Williams, Tom A. Dreads and Besetting Fears=Including States of Anxiety; Their Causes and Cure. Boston. Little, Brown and Co., 1923. Pp. xv + 217. Price, $1.75; 1923. Page Count: 2. Issue Publication Date: Jul-Sep, 1923. Copyright Statement: American Psychological Association. 1923.
KW - dreads
KW - fears
KW - phobias
KW - 1923
KW - Anxiety
KW - Emotional Control
KW - Fear
KW - Phobias
U2 - Williams, Tom A. (1923); Dreads and Besetting Fears; Including States of Anxiety; Their Causes and Cure. Boston. Little, Brown and Co., 1923. Pp. xv + 217. Price, $1.75
DO - 10.1037/h0066538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=2005-13857-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 2005-13857-006
AN - 2005-13857-006
AU - Dearborn, George Van Ness
T1 - Review of The Unadjusted Girl, with Cases and Standpoint for Behavior Analysis.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1923/07//Jul-Sep, 1923
VL - 18
IS - 2
SP - 180
EP - 182
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13857-006. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George Van Ness; U. S. Public Health Service Reserve, NY, US. Release Date: 20060327. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Behavior Analysis; Unwed Mothers. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Reviewed Item: Thomas, William I. The Unadjusted Girl, with Cases and Standpoint for Behavior Analysis=With a Foreword by Mrs. W. F. Dummer. Boston. Little, Brown & Co., 1923. Pp. xix + 261. Price, $3; 1923. Page Count: 3. Issue Publication Date: Jul-Sep, 1923. Copyright Statement: American Psychological Association. 1923.
AB - Reviews the book, The Unadjusted Girl, with Cases and Standpoint for Behavior Analysis by William I. Thomas (see record [rid]1923-10387-000[/rid]). Fundamentally, the book marks another step in the general recognition of the old dictum that to understand all is to forgive all, that care and cure, not punishment, are due the girl who has a baby for the cradle before she has a husband for her home. About a hundred case-histories are given and discussed in this thoughtful book. Besides the interesting and constructive Foreword by Mrs. Dummer, there are six chapters on wishes, the regulation of wishes, the 'individualization of behavior,' the 'demoralization of girls,' social agencies, and the 'measurement of social influence.' Altogether, this book is an important one for applied sociology and one as significant for many parents of 'growing' girls as for social service and psychology. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - behavior analysis
KW - unwed mothers
KW - 1923
KW - Behavior Analysis
KW - Unwed Mothers
KW - 1923
U2 - Thomas, William I. (1923); The Unadjusted Girl, with Cases and Standpoint for Behavior Analysis; With a Foreword by Mrs. W. F. Dummer. Boston. Little, Brown & Co., 1923. Pp. xix + 261. Price, $3
DO - 10.1037/h0067374
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13857-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13857-008
AN - 2005-13857-008
AU - Dearborn, George Van Ness
T1 - Review of Dreads and besetting fears, including states of anxiety, their causes and cure.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1923/07//Jul-Sep, 1923
VL - 18
IS - 2
SP - 183
EP - 184
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13857-008. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George Van Ness; U. S. Public Health Service Reserve, NY, US. Release Date: 20060327. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Anxiety; Emotional Control; Fear; Phobias. Classification: Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Williams, Tom A. Dreads and Besetting Fears=Including States of Anxiety; Their Causes and Cure. Boston. Little, Brown and Co., 1923. Pp. xv + 217. Price, $1.75; 1923. Page Count: 2. Issue Publication Date: Jul-Sep, 1923. Copyright Statement: American Psychological Association. 1923.
AB - Reviews the book, Dreads and Besetting Fears by Tom A. Williams (see record [rid]1923-10366-000[/rid]). Fourteen chapters make up the book, and their titles indicate its contents: 'Early origins of dreads; Bashfulness and kindred states; College breakdowns; Fear and stammering; Anxiety states; Occupational phobias; Fear of crowds, open spaces, etc.; Other common phobias; Physical conditions and fear; Heredity and fear; Fear by induction; the Fascination of fear; the Utilization and management of fear; and the Dispelling of fear.' Doctor Williams of Washington is to be heartily congratulated on a readable and highly useful book. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - dreads
KW - fears
KW - phobias
KW - 1923
KW - Anxiety
KW - Emotional Control
KW - Fear
KW - Phobias
KW - 1923
U2 - Williams, Tom A. (1923); Dreads and Besetting Fears; Including States of Anxiety; Their Causes and Cure. Boston. Little, Brown and Co., 1923. Pp. xv + 217. Price, $1.75
DO - 10.1037/h0066538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13857-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13385-005
AN - 2005-13385-005
AU - Van Ness Dearborn, George
T1 - Review of The eugenic prospect: National and racial.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/01//
VL - 18
IS - 4
SP - 416
EP - 417
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13385-005. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology. Partial author list: First Author & Affiliation: Van Ness Dearborn, George; United States Public Health Service Reserve, NY, US. Release Date: 20060329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Eugenics; Social Psychology. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Saleeby, C. W. The eugenic prospect: National and racial=New York. Dodd, Mead & Co., Pp. 239; 1921. Page Count: 2. Issue Publication Date: Jan, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, The Eugenic prospect: National and racial by C. W. Saleeby (1921). This volume, "dedicated to the cause of Anglo-American Friendship for the Weal of All Mankind," is a continuation in a way of "The Whole Armour of Man," published in 1919. "Its pages are dominated from first to last by the series of revelations and inspirations and instructions which America, our tremendous offspring, offers to the visitor and student from these Mother-islands." "Only such a mother could have such a daughter." The volume for several good reasons merits the attention of all students of the conditions underlying social and personal psychology, normal and morbid. Dr. Saleeby is "doing good work" spreading the gospels of well-living and of international harmony-two high ideals. (PsycINFO Database Record (c) 2013 APA, all rights reserved)
KW - social psychology
KW - personal psychology
KW - eugenics
KW - 1924
KW - Eugenics
KW - Social Psychology
U2 - Saleeby, C. W. (1921); The eugenic prospect: National and racial; New York. Dodd, Mead & Co., Pp. 239
DO - 10.1037/h0067278
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=2005-13385-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 2005-13385-003
AN - 2005-13385-003
AU - Van Ness Dearborn, George
T1 - Review of Abnormal Behavior: Pitfalls of our minds: An introduction to the study of abnormal and anti-social behavior.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/01//
VL - 18
IS - 4
SP - 413
EP - 414
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13385-003. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Van Ness Dearborn, George; United States Public Health Service Reserve, NY, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Antisocial Behavior; Conduct Disorder; Neuropsychiatry; Social Casework. Minor Descriptor: Abnormal Psychology; Psychologists; Social Workers. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Reviewed Item: Sands, Irving J.; Blanchard, Phyllis. Abnormal Behavior: Pitfalls of our minds: An introduction to the study of abnormal and anti-social behavior=New York. Moffat, Yard & Co., Pp. ix + 482. Price $4.00; 1923. Page Count: 2. Issue Publication Date: Jan, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Abnormal Behavior: Pitfalls of our minds: An introduction to the study of abnormal and anti-social behavior by Irving J. Sands and Phyllis Blanchard (1923). This is of the nature of a textbook of neuropsychiatry as understood of late so broadly, but adapted particularly to novices therein and to 'social workers.' The space is taken up largely with 137 brief case histories of conduct-disorder and discussion of these, often with much insight. The subtitle seems to have no special appropriateness. No chapter will meet with wider approval from professionals than the last, devoted to prevention and correction. In it are discussed many topics timely for 'applying' psychologists and sociologists. The book is another example of the waste of space in printing sociologic case histories that has been so obvious of late in many books of import similar to this book. No two human behaviors are alike outwardly and in motive; to publish them seems to savor more of catering to a love of a sort of gossip than to scientific usefulness. But the book certainly as a whole is a valuable one, even at a high price. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - anti-social behavior
KW - abnormal behavior
KW - sociologic case histories
KW - neuropsychiatry
KW - conduct disorder
KW - 1924
KW - Antisocial Behavior
KW - Conduct Disorder
KW - Neuropsychiatry
KW - Social Casework
KW - Abnormal Psychology
KW - Psychologists
KW - Social Workers
KW - 1924
U2 - Sands, Irving J.; Blanchard, Phyllis. (1923); Abnormal Behavior: Pitfalls of our minds: An introduction to the study of abnormal and anti-social behavior; New York. Moffat, Yard & Co., Pp. ix + 482. Price $4.00
DO - 10.1037/h0067851
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13385-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13385-005
AN - 2005-13385-005
AU - Van Ness Dearborn, George
T1 - Review of The eugenic prospect: National and racial.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/01//
VL - 18
IS - 4
SP - 416
EP - 417
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13385-005. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Van Ness Dearborn, George; United States Public Health Service Reserve, NY, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Eugenics; Social Psychology. Classification: Social Psychology (3000). Population: Human (10). Reviewed Item: Saleeby, C. W. The eugenic prospect: National and racial=New York. Dodd, Mead & Co., Pp. 239; 1921. Page Count: 2. Issue Publication Date: Jan, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, The Eugenic prospect: National and racial by C. W. Saleeby (1921). This volume, 'dedicated to the cause of Anglo-American Friendship for the Weal of All Mankind,' is a continuation in a way of 'The Whole Armour of Man,' published in 1919. 'Its pages are dominated from first to last by the series of revelations and inspirations and instructions which America, our tremendous offspring, offers to the visitor and student from these Mother-islands.' 'Only such a mother could have such a daughter.' The volume for several good reasons merits the attention of all students of the conditions underlying social and personal psychology, normal and morbid. Dr. Saleeby is 'doing good work' spreading the gospels of well-living and of international harmony-two high ideals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social psychology
KW - personal psychology
KW - eugenics
KW - 1924
KW - Eugenics
KW - Social Psychology
KW - 1924
U2 - Saleeby, C. W. (1921); The eugenic prospect: National and racial; New York. Dodd, Mead & Co., Pp. 239
DO - 10.1037/h0067278
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13385-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13911-014
AN - 2005-13911-014
AU - Dearborn, George Van Ness
T1 - Review of Plots and personalities: A new method of testing and training the creative imagination.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/04//
VL - 19
IS - 1
SP - 107
EP - 108
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13911-014. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology. Partial author list: First Author & Affiliation: Dearborn, George Van Ness; U. S. Public Health Service Reserve, New York, NY, US. Release Date: 20060329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Creativity; Imagination; Personality Traits; Testing. Classification: Personality Scales & Inventories (2223); Personality Traits & Processes (3120). Population: Human (10). Reviewed Item: Slosson, Edwin E.; Downey, June E. Plots and personalities: A new method of testing and training the creative imagination=New York. The Century Co., 1922. Pp. iii + 238. Price $1.73. 12mo; 1922. Page Count: 2. Issue Publication Date: Apr, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Plots and personalities: A new method of testing and training the creative imagination by Edwin E. Slosson and June E. Downey (see record [rid]1924-10394-000[/rid]). The unusual length of time that this book has been unreviewed on the reviewer's study table in a way is an index of the difficulty of reviewing it. The publishers say: "This is the queerest book we have ever published, and one of the most interesting," and with them in this we go at least half way. And, again: "The book is for everybody in general and the literary person in particular. It undertakes to cast some light on the creative faculty and it explains in non-technical language the psychological principles of plot-making and character creation. There are chapters on other forms of fiction than stories, such a day-dreaming, make-believe, lying, gossiping, imaginary companions, pen-personalities and other psychological alibis." In this we gladly go with the publishers the psychological limit. (PsycINFO Database Record (c) 2013 APA, all rights reserved)
KW - personalities
KW - testing
KW - creative imagination
KW - 1924
KW - Creativity
KW - Imagination
KW - Personality Traits
KW - Testing
U2 - Slosson, Edwin E.; Downey, June E. (1922); Plots and personalities: A new method of testing and training the creative imagination; New York. The Century Co., 1922. Pp. iii + 238. Price $1.73. 12mo
DO - 10.1037/h0068439
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=2005-13911-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 2005-13911-013
AN - 2005-13911-013
AU - Dearborn, George Van Ness
T1 - Review of Nervous and mental re-education.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/04//
VL - 19
IS - 1
SP - 107
EP - 107
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13911-013. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George Van Ness; U. S. Public Health Service Reserve, New York, NY, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Cognitive Processes. Minor Descriptor: Habits; Motor Processes. Classification: Cognitive Processes (2340). Population: Human (10). Reviewed Item: Franz, Shepherd Ivory. Nervous and mental re-education=New York. The Macmillan Company, 1923. Pp. ix + 225. Price $2.00; 1923. Page Count: 1. Issue Publication Date: Apr, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Nervous and mental re-education by Shepherd Ivory Franz (see record [rid]1923-10402-000[/rid]). This book is an elementary treatise that will be of suggestive value to many a physiotherapist and to numerous physicians. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nervous
KW - mental reeducation
KW - 1924
KW - Cognitive Processes
KW - Habits
KW - Motor Processes
KW - 1924
U2 - Franz, Shepherd Ivory. (1923); Nervous and mental re-education; New York. The Macmillan Company, 1923. Pp. ix + 225. Price $2.00
DO - 10.1037/h0069714
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13911-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13912-017
AN - 2005-13912-017
AU - Dearborn, George VanNess
T1 - Review of Love in Children and Its Aberrations: A Book for Parents and Teachers.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/07//
VL - 19
IS - 2
SP - 206
EP - 208
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13912-017. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology. Partial author list: First Author & Affiliation: Dearborn, George VanNess; U.S. Public Health Service Reserve, NY, US. Release Date: 20060329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Freudian Psychoanalytic School; Love. Classification: Developmental Psychology (2800); Psychoanalytic Theory (3143). Age Group: Childhood (birth-12 yrs) (100). Reviewed Item: Pfister, Oskar. Love in Children and Its Aberrations: A Book for Parents and Teachers=New York. Dodd, Mead and Company, 1924. Pp. 576; 1924. Page Count: 3. Issue Publication Date: Jul, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Love in Children and Its Aberrations: A Book for Parents and Teachers by Oskar Pfister (1924). This is another and an elaborate discussion of child-behavior and motivation from the Freudian point of view. "When we contemplate love in children, we are not looking into a charming and tranquil garden, but into a world that often arouses horror, pity, and even disgust." In other words, here is one more writer of books, another tolerably well-known psychologist whose garden of Eden is inhabited mostly by snakes, recently discovered and described somewhat and classified. As the author himself hints, he seems to have little acquaintance with actual, living children. The book is made up mostly of reports of the psychoanalyses of adults and of adolescents, with numerous Freudian arguments and animadversions on the data so derived, and the Freudisms so suggested. And one gets fed up ad nauseam (if the bit of slang be allowed for variety's sake) on the almost universal presupposition of the "Oedipus complex" in children's minds--a true obsession in the author's mental process. A few instances of the reality are exaggerated into a supposed generality of the passion among children in general. (PsycINFO Database Record (c) 2013 APA, all rights reserved)
KW - children
KW - love
KW - Freudian psychoanalytic theory
KW - 1924
KW - Freudian Psychoanalytic School
KW - Love
U2 - Pfister, Oskar. (1924); Love in Children and Its Aberrations: A Book for Parents and Teachers; New York. Dodd, Mead and Company, 1924. Pp. 576
DO - 10.1037/h0064667
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=2005-13912-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 2005-13912-017
AN - 2005-13912-017
AU - Dearborn, George VanNess
T1 - Review of Love in Children and Its Aberrations: A Book for Parents and Teachers.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1924/07//
VL - 19
IS - 2
SP - 206
EP - 208
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-13912-017. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George VanNess; U.S. Public Health Service Reserve, NY, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Freudian Psychoanalytic School; Love. Classification: Developmental Psychology (2800); Psychoanalytic Theory (3143). Age Group: Childhood (birth-12 yrs) (100). Reviewed Item: Pfister, Oskar. Love in Children and Its Aberrations: A Book for Parents and Teachers=New York. Dodd, Mead and Company, 1924. Pp. 576; 1924. Page Count: 3. Issue Publication Date: Jul, 1924. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Love in Children and Its Aberrations: A Book for Parents and Teachers by Oskar Pfister (1924). This is another and an elaborate discussion of child-behavior and motivation from the Freudian point of view. 'When we contemplate love in children, we are not looking into a charming and tranquil garden, but into a world that often arouses horror, pity, and even disgust.' In other words, here is one more writer of books, another tolerably well-known psychologist whose garden of Eden is inhabited mostly by snakes, recently discovered and described somewhat and classified. As the author himself hints, he seems to have little acquaintance with actual, living children. The book is made up mostly of reports of the psychoanalyses of adults and of adolescents, with numerous Freudian arguments and animadversions on the data so derived, and the Freudisms so suggested. And one gets fed up ad nauseam (if the bit of slang be allowed for variety's sake) on the almost universal presupposition of the 'Oedipus complex' in children's minds--a true obsession in the author's mental process. A few instances of the reality are exaggerated into a supposed generality of the passion among children in general. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children
KW - love
KW - Freudian psychoanalytic theory
KW - 1924
KW - Freudian Psychoanalytic School
KW - Love
KW - 1924
U2 - Pfister, Oskar. (1924); Love in Children and Its Aberrations: A Book for Parents and Teachers; New York. Dodd, Mead and Company, 1924. Pp. 576
DO - 10.1037/h0064667
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13912-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-14132-014
AN - 2005-14132-014
AU - Dearborn, George VanNess
T1 - Review of Days of delusion: A strange bit of history.
JF - The Journal of Abnormal Psychology and Social Psychology
JO - The Journal of Abnormal Psychology and Social Psychology
Y1 - 1925/01//
VL - 19
IS - 4
SP - 436
EP - 437
CY - US
PB - American Psychological Association
SN - 0145-2347
N1 - Accession Number: 2005-14132-014. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal and Social Psychology; The Journal of Abnormal Psychology. Partial author list: First Author & Affiliation: Dearborn, George VanNess; U. S. Public Health Service Reserve, NY, US. Release Date: 20060327. Correction Date: 20121119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Death Anxiety; Delusions; Social Cognition; Social Psychology. Classification: Social Psychology (3000). Population: Human (10). Location: US. Reviewed Item: Sears, Clara Endicott. Days of delusion: A strange bit of history=Boston: Houghton Mifflin Company, 1924. Pp. xxvi + 264. Forty illustrations. Price $3.00; 1924. Page Count: 2. Issue Publication Date: Jan, 1925. Copyright Statement: American Psychological Association. 1924.
AB - Reviews the book, Days of delusion: A strange bit of history by Clara Endicott Sears (1924). This essay in the historical branch of social psychology makes an important contribution to the history of American life and in a form more interesting than all but the very exceptional novel. It deals with the rise and fall of the delusion in the social mind of America between, say, 1830 and 1845, that the world was coming to an end in 1843 or later. As in all of Miss Sears's books and stories, there is an intense human interest in the present work; notably of value too, is the biography of William Miller as a human document in itself--the simple story of a sincere and religious man beguiled as much as beguilding by the unrealized growth of a fixed idea--a brave soldier, a man thoroughly good, and true to his ideals. His life already has been written by Sylvester Bliss. His obsession is one more excellent example of the way prophets (save those based on wide knowledge, deep wisdom, and keen reasoning) are made. Every student of psychology is indebted to Clara Endicott Sears for this elaborate case history. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social psychology
KW - delusion
KW - end of the world
KW - social mind
KW - 1925
KW - Death Anxiety
KW - Delusions
KW - Social Cognition
KW - Social Psychology
KW - 1925
U2 - Sears, Clara Endicott. (1924); Days of delusion: A strange bit of history; Boston: Houghton Mifflin Company, 1924. Pp. xxvi + 264. Forty illustrations. Price $3.00
DO - 10.1037/h0068102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-14132-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-35719-002
AN - 2013-35719-002
AU - Preston, George H.
AU - Shepler, Winifred McLane
T1 - A study of the problems of 'normal' children.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1931/04//
VL - 1
IS - 3
SP - 245
EP - 256
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-35719-002. Partial author list: First Author & Affiliation: Preston, George H.; Office of Field Investigations in Child Hygiene, United States Public Health Service, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Meeting of the American Orthopsychiatric Association, 1931. Conference Note: This research was presented at the aforementioned conference. Major Descriptor: Behavior Problems; Emotional Content; Emotional Development. Minor Descriptor: Observers. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adulthood (18 yrs & older) (300). Tests & Measures: Illinois General Intelligence Scale; Binet-Simon Scale. Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Apr, 1931.
AB - This study was undertaken with the idea of collecting normal controls against which our present ideas of problem children might be evaluated. Confronted by a problem child we study his behavior and his attitudes toward the circumstances and personalities with which he is surrounded. We note parental ambitions and emotional fixations, sibling rivalries and teacher attitudes and we then evaluate our findings in terms of a hypothetical normal which exists largely in the mind of the observer. Our method produces a brightly drawn picture because it is presented against a background of 'normality' which is assumed to be homogeneous and uninteresting. If normality is homogeneous, if 'average' children conform to a type which can be shown to be different from that found for children who are labeled 'problem,' then the pictures which we produce of problem children do bear a relation to actually existing conditions. The background of 'normality' cannot be assumed. This study was undertaken in an attempt to produce some evidence as to the actual configuration of this background. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - problem child
KW - observers
KW - child behavior
KW - emotional fixations
KW - 1931
KW - Behavior Problems
KW - Emotional Content
KW - Emotional Development
KW - Observers
KW - 1931
DO - 10.1111/j.1939-0025.1931.tb04819.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-35719-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-001
AN - 2014-49261-001
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - Historical considerations.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 19
EP - 39
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-001. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Correctional Institutions; Criminal Behavior; Criminal Rehabilitation; History; Prisons. Minor Descriptor: Education; Prisoners; Psychiatry; Religious Education; Social Services. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: Europe; US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 21.
AB - Prisons in the modern sense of the word are comparatively new institutions, and as a means designed to reform the criminal, they are distinctly a 19th century product. This chapter considers the history of prisons, discussing the following topics: Prisons in ancient times; Imprisonment by the Church; The Quaker influence on prison systems; Origin of the penitentiary; John Howard and Elizabeth Fry; The solitary system; The silent system; Prisons as reformative agencies; Aids to reformation in prison; Religious instruction in early prisons; Decline of individual religious instruction; Religious instruction replaced by social service; Scope of social service in modern prisons; Physical rehabilitation; Psychiatry in prison; Function of the psychiatrist in prison; Public benefit conferred by medical rehabilitation of prisoners; Education in the broadest sense; Education in the restricted sense; Aim of education; Discipline dominates the picture; Discipline necessary; Present status of classification; Classification by type of institution; Classification in other countries; and Classification within the prison. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - history
KW - prisons
KW - imprisonment
KW - prison systems
KW - reformative agencies
KW - prison reform
KW - religious instruction
KW - social services
KW - physical rehabilitation
KW - psychiatry
KW - mental rehabilitation
KW - education
KW - discipline
KW - prisoner classification
KW - 1939
KW - Correctional Institutions
KW - Criminal Behavior
KW - Criminal Rehabilitation
KW - History
KW - Prisons
KW - Education
KW - Prisoners
KW - Psychiatry
KW - Religious Education
KW - Social Services
KW - 1939
DO - 10.1037/14698-001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-002
AN - 2014-49261-002
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - A difficult problem.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 40
EP - 53
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-002. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Rehabilitation; Personality Change; Prisoners; Prisons. Minor Descriptor: Prison Personnel. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 14.
AB - Reformation of character is a a difficult problem under the most ideal environment, and no one who has firsthand knowledge of prisons would choose even the best of them for this purpose if he could possibly avoid it. In this chapter, the authors consider the following topics: Prison environment not conducive to reformation; Custodial and rehabilitative measures often conflict; The significance of rigid regimentation; Fraternization of prisoners with custodial force; Coddling of prisoners; Life without women; Mental habits cannot be controlled by force; Meaning of rehabilitation and reformation; Explanation of the term, 'Force'; Conflicting viewpoints compromised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - reformation of character
KW - prisoners
KW - prisons
KW - prison environments
KW - custodial measures
KW - rehabilitative measures
KW - fraternization
KW - custodial force
KW - mental habits
KW - reformation
KW - 1939
KW - Criminal Rehabilitation
KW - Personality Change
KW - Prisoners
KW - Prisons
KW - Prison Personnel
KW - 1939
DO - 10.1037/14698-002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-003
AN - 2014-49261-003
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - Attempts to solve the problem.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 54
EP - 63
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-003. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Rehabilitation; Individual Differences; Prisoners; Prisons; Psychosocial Rehabilitation. Minor Descriptor: Mental Disorders; Personality; Psychiatry; Treatment. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Binet Test. Page Count: 10.
AB - Modern penologists believe that if prisons are to have any truly reformative influence upon the character of their inmates due consideration should be given to their individual characteristics, as well as to the particular crime they may have committed. In prison as well as out we find a great diversity of personalities and the problem becomes one of recognizing and defining these personalities in practical terms. By practical terms we mean not only those which admit of accurate definitions, and carry a clear mental image of the type of individual with whom we are dealing, but we also mean terms so simple that the prison population can be readily classified into the fewest possible number of groups consistent with individual treatment and congregate administration. In this chapter, the following topics are discussed: General principles to be observed in classification; The Federal plan for practical application of general principles; Case history illustrating application of the plan; and Psychiatric factors most important. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prisoner treatment classification
KW - psychological processes
KW - prisoners
KW - individual characteristics
KW - prison
KW - personality diversity
KW - treatment administration
KW - psychiatric factors
KW - 1939
KW - Criminal Rehabilitation
KW - Individual Differences
KW - Prisoners
KW - Prisons
KW - Psychosocial Rehabilitation
KW - Mental Disorders
KW - Personality
KW - Psychiatry
KW - Treatment
KW - 1939
DO - 10.1037/14698-003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-004
AN - 2014-49261-004
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The normal prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 64
EP - 75
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-004. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Behavior; Criminals; Patient History; Prisoners. Minor Descriptor: Education; Environment; Genetics; Human Body; Instinctive Behavior; Personality. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 12.
AB - In this chapter, the authors discuss what is meant by the 'normal' prisoner, focusing on the following topics: Meaning of normal; Normal bodies; Normal temperaments and instincts; Illustrative case histories; Normal heredity; Normal environment; Normal education; Convicts frequently normal in every way; and Kind of crimes committed by normal criminals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - normal classification
KW - normal prisoners
KW - bodies
KW - temperaments
KW - instincts
KW - heredity
KW - environment
KW - education
KW - prisoners
KW - crimes
KW - 1939
KW - Criminal Behavior
KW - Criminals
KW - Patient History
KW - Prisoners
KW - Education
KW - Environment
KW - Genetics
KW - Human Body
KW - Instinctive Behavior
KW - Personality
KW - 1939
DO - 10.1037/14698-004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-005
AN - 2014-49261-005
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The feeble-minded prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 76
EP - 95
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-005. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Differential Diagnosis; Prisoners; Treatment; Intellectual Development Disorder. Minor Descriptor: Crime; Criminal Behavior; Dementia; Genetics; Intelligence Measures; Mental Disorders; Prisons. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30). Location: US. Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Binet-Simon Test; Army Alpha Examination; Pintner-Patterson Performance test; Ferguson Form Boards; Intelligence Test; Army Beta Examination. Page Count: 20.
AB - Men in prison, whether they be of normal or subnormal intelligence, are still men, and the psychological principles of governing conduct apply to them the same as to others. Therefore, it is appropriate to discuss feeble-mindedness in general terms before making specific reference to the feeble-minded prisoner. In this chapter the following topics are discussed: Definition in sociobiological terms; Differentiation from insanity and dementia; Definition in psychometric terms; Psychometric tests applied to prisoners; Clinical types; Theoretical and practical aspects; The influence of heredity; Differentiation and diagnosis of the different types of the feeble-minded; Feeble-mindedness as a cause of crime; Types of crime committed by the feeble-minded; and Treatment of the feeble-minded prisoner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - feeble-minded prisoner
KW - subnormal intelligence
KW - psychometric tests
KW - insanity
KW - dementia
KW - heredity
KW - differential diagnosis
KW - crime
KW - 1939
KW - Differential Diagnosis
KW - Prisoners
KW - Treatment
KW - Intellectual Development Disorder
KW - Crime
KW - Criminal Behavior
KW - Dementia
KW - Genetics
KW - Intelligence Measures
KW - Mental Disorders
KW - Prisons
KW - 1939
DO - 10.1037/14698-005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-006
AN - 2014-49261-006
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The psychoneurotic prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 96
EP - 121
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-006. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Rehabilitation; Neurosis; Prisoners; Psychosocial Rehabilitation; Treatment. Minor Descriptor: Major Depression; Neuropsychiatry; Prisons; Psychiatric Symptoms; Psychotherapy. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 26.
AB - The definitions of psychoneurosis may be as varied as the proverbial blind men's descriptions of the elephant. Statistical analysis of psychoneurotic inmates compared with nonpsychoneurotic inmates found an association of psychoneurosis with disrupted home life and poor health. In this chapter, the following topics are discussed: Conflicting theories; The materialistic theory; The psychogenic theory; Definition of the term; Symptoms; Prevalence of the psychoneuroses in prison; Crimes committed by psychoneurotics; Reactive depressions among prisoners; Other types of psychoneurotic prisoners; Responsibility of the psychiatrist; Diagnosis of psychoneurosis from malingering; Importance of neuropsychiatric examinations of prisoners; General principles for treatment; Correction of physical defects; Hygienic measure; Hydro-, electro-, physio-, and drug therapy; Psychotherapy; Limitation and scope of treatment in prison; Value of harsh treatment in certain cases; Mental ventilation, hypnosis, and suggestion; Changing the environment in prison; and Three environmental levels in prison. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nonpsychoneurotic inmates
KW - disrupted home life
KW - psychoneurotic prisoners
KW - neuropsychiatric examinations
KW - theories of psychoneurosis
KW - psychiatric symptoms
KW - reactive depression
KW - psychiatrist responsibility
KW - malingering
KW - neuropsychiatry
KW - psychotherapy
KW - prison environment
KW - 1939
KW - Criminal Rehabilitation
KW - Neurosis
KW - Prisoners
KW - Psychosocial Rehabilitation
KW - Treatment
KW - Major Depression
KW - Neuropsychiatry
KW - Prisons
KW - Psychiatric Symptoms
KW - Psychotherapy
KW - 1939
DO - 10.1037/14698-006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-007
AN - 2014-49261-007
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The psychopathic prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 122
EP - 143
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-007. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Antisocial Personality Disorder; Crime; Prisoners; Treatment. Minor Descriptor: Crime Prevention; Criminal Rehabilitation; Diagnosis; Environment; Genetics; Psychiatric Symptoms; Psychopathy; Psychosocial Rehabilitation. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 22.
AB - The term psychopathic personality is applied to the members of an extremely heterogeneous group of 'half-crazy' individuals who cannot be called legally insane, but who obviously have something queer about them. Borderline psychotics, sexual perverts, hoboes, habitual drunkards, drug addicts, cranks, malingerers, criminals, misanthropes, and a host of other misfits who apparently cannot be properly pigeonholed elsewhere find themselves labeled constitutional psychopathic inferiors, or, less formidably, psychopathic personalities. In this chapter, the following topics are discussed: Difficulty of defining the term; Arguments for discarding the term; Arguments for retaining the term; Interplay of heredity and environment; Pathology a necessary element in the definition; The definition must exclude the feeble-minded; The definition must exclude the psychoneuroses; The completed definition; Symptomatology and diagnosis; Psychopaths are sometimes useful members of society; The psychopath is sometimes harmless; Psychopathic personality in relation to crime; Importance of correct diagnosis; Aids to diagnosis; Nature of crime a poor criterion; Criminal psychopaths consistently antisocial; General principles for treatment; General principles for prevention; and Specific application of principles to prisoners. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathic personality
KW - constitutional psychopathic inferiors
KW - psychopathic personalities
KW - psychopathic prisoner
KW - crime
KW - treatment
KW - prevention
KW - diagnosis
KW - symptoms
KW - heredity
KW - environment
KW - 1939
KW - Antisocial Personality Disorder
KW - Crime
KW - Prisoners
KW - Treatment
KW - Crime Prevention
KW - Criminal Rehabilitation
KW - Diagnosis
KW - Environment
KW - Genetics
KW - Psychiatric Symptoms
KW - Psychopathy
KW - Psychosocial Rehabilitation
KW - 1939
DO - 10.1037/14698-007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-008
AN - 2014-49261-008
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The psychotic (insane) prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 144
EP - 167
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-008. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Prisoners; Prisons; Psychosis; Treatment. Minor Descriptor: Crime; Criminal Rehabilitation; Etiology; Malingering; Mental Disorders; Psychiatric Symptoms; Psychosocial Rehabilitation; Suicide. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 24.
AB - Insanity has long been a controversial subject between the legal and medical professions. The authors will not attempt to cloud the issue by adding a definition of their own, but will simply present both sides of the question and then turn to a more or less neutral source for a practical definition of mental incompetency. In this chapter, the following topics are discussed: The legal opinion of insanity; The medical opinion of insanity; Remedial measures; Practical definition of insanity; Etiology; Functional psychoses; Psychobiologic theory; Symptomatology; Common characteristics; Statistical data; Imprisonment as a cause of insanity; Insanity as a cause of crime; Characteristic prison psychoses; Other psychoses; Malingered insanity; Treatment; Prevention in general; Treatment of psychotic patients; Mental hygiene in prison; Suicide in prison; Place of the psychiatrist in mental hygiene; Treatment of psychotic prisoners; and Relation of punishment to insanity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental hygiene
KW - psychotic prisoners
KW - insane prisoners
KW - prison psychoses
KW - psychotic patients
KW - etiology
KW - functional psychoses
KW - symptoms
KW - crime
KW - malingering insanity
KW - treatment
KW - suicide
KW - psychiatrists
KW - 1939
KW - Prisoners
KW - Prisons
KW - Psychosis
KW - Treatment
KW - Crime
KW - Criminal Rehabilitation
KW - Etiology
KW - Malingering
KW - Mental Disorders
KW - Psychiatric Symptoms
KW - Psychosocial Rehabilitation
KW - Suicide
KW - 1939
DO - 10.1037/14698-008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-009
AN - 2014-49261-009
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The neuropathic prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 168
EP - 194
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-009. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Central Nervous System Disorders; Crime; Neuropathology; Prisoners. Minor Descriptor: Alcohol Abuse; Alcoholism; Criminal Rehabilitation; Disorders; Drug Addiction; Drugs; Epilepsy; Injuries; Personality Change; Treatment. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 27.
AB - In this chapter, the authors describe the neuropathic prisoner, defined as those individuals who show unfavorable personality and character changes as a result of injury, disease or intoxication of the central nervous system, these changes falling short of actual insanity. In this chapter, the following topics are discussed: Etiology and symptomatology; The epileptic criminal; Relation of epilepsy to crime; Treatment of epileptics in prison; Alcoholism and drug addiction; Alcoholic criminals; Alcoholism in prison; Drug-addicted criminals; Relation of drug addiction to crime; Drug addiction in prison; Custodial features of drug addiction; and Neuropaths primarily medical problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuropathic prisoner
KW - unfavorable personality
KW - character changes
KW - injury
KW - disease
KW - intoxication
KW - central nervous system
KW - epilepsy
KW - etiology
KW - symptom
KW - crime
KW - alcoholism
KW - drug addiction
KW - medical problems
KW - 1939
KW - Central Nervous System Disorders
KW - Crime
KW - Neuropathology
KW - Prisoners
KW - Alcohol Abuse
KW - Alcoholism
KW - Criminal Rehabilitation
KW - Disorders
KW - Drug Addiction
KW - Drugs
KW - Epilepsy
KW - Injuries
KW - Personality Change
KW - Treatment
KW - 1939
DO - 10.1037/14698-009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-010
AN - 2014-49261-010
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The homosexual prisoner.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 195
EP - 210
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-010. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Bisexuality; Male Homosexuality; Prisoners; Prisons. Minor Descriptor: Community Attitudes; Criminal Rehabilitation; Epidemiology; Prevention; Psychosocial Rehabilitation; Treatment. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 16.
AB - In this chapter, the authors discuss homosexual prisoners. The following topics are discussed: Definition; Varieties of homosexuals; Active and passive homosexuals; Bisexuality; The temporary homosexual; Homosexuality acquired in prison; Homosexuality a menace to the race; Prevalence of homosexuality; Number of homosexuals in prison; Recognition of the homosexual; Signs detected by the application of common sense; Signs elicited through the application of psychological principles; Signs detected by primary physical examination; Signs detected at secondary physical examination; Summarizing the evidence; Treatment of the homosexual prisoner; General principles for prevention; Prevention through correct community attitudes; and Prevention through surveillance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homosexual prisoners
KW - homosexuality
KW - bisexuality
KW - prison environments
KW - prevalence
KW - treatment
KW - prevention
KW - community attitudes
KW - 1939
KW - Bisexuality
KW - Male Homosexuality
KW - Prisoners
KW - Prisons
KW - Community Attitudes
KW - Criminal Rehabilitation
KW - Epidemiology
KW - Prevention
KW - Psychosocial Rehabilitation
KW - Treatment
KW - 1939
DO - 10.1037/14698-010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-011
AN - 2014-49261-011
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The recidivist.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 211
EP - 225
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-011. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Behavior; Criminals; Recidivism. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 15.
AB - This chapter is devoted mainly to ascertaining the earmarks by which an habitual criminal may be distinguished regardless of the psychiatric group to which he may belong. In this chapter, the following topics are discussed: Physical appearance of recidivists; Extreme selfishness characteristic of all recidivists; Accidental contrasted with confirmed criminal type; 'Cherchez la femme'; Freedom from remorse characteristic of the recidivist; Feeble-minded; Psychoneurotic; Neuropathic; Psychopathic personality; Psychotic; Normal recidivist; and Statistics regarding recidivism. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - habitual criminals
KW - characteristics
KW - criminal types
KW - psychiatric groups
KW - 1939
KW - Criminal Behavior
KW - Criminals
KW - Recidivism
KW - 1939
DO - 10.1037/14698-011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-012
AN - 2014-49261-012
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - Discipline in prison.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 226
EP - 250
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-012. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Prisoners; Prisons; Punishment. Minor Descriptor: Motivation; Personality; Psychiatry. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 25.
AB - This chapter focuses on discipline in prison. The following topics are discussed: Principles underlying successful discipline; The value of regimentation; Unexpected results from cruel treatment; Disciplinary measures as an element of punishment; Punishment to preserve discipline; Cruelty a relative term; Different viewpoints concerning the purpose of discipline; Mental attitudes which interfere with modern methods; Psychiatric viewpoint in the ascendancy; Merits of the various types of discipline; Understanding the prisoner; The personality of recalcitrant prisoners; Motives for breaking rules; and Relation of psychiatry to discipline. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - discipline
KW - prison
KW - prisoners
KW - punishment
KW - cruelty
KW - mental attitudes
KW - psychiatry
KW - personality
KW - recalcitrance
KW - motivation
KW - 1939
KW - Prisoners
KW - Prisons
KW - Punishment
KW - Motivation
KW - Personality
KW - Psychiatry
KW - 1939
DO - 10.1037/14698-012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2014-49261-013
AN - 2014-49261-013
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - The value of imprisonment.
T2 - Problems in prison psychiatry.
Y1 - 1939///
SP - 251
EP - 265
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-013. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Criminal Rehabilitation; Prisoners; Prisons; Psychosocial Rehabilitation. Minor Descriptor: Mental Disorders; Punishment; Recidivism; Social Issues. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 15.
AB - The main psychiatric groups under which all prisoners can be conveniently classified, and some of the special problems of prison administration common to all these groups, it is pertinent to conclude our subject with an inquiry into the value of imprisonment. This value should be studied from two angles; first, the benefits accruing to society through rehabilitation and punishment of the prisoner, and, second, the benefits which these measures confer upon the prisoner himself. In this chapter, the following topics are discussed: Imprisonment as a means of rehabilitation; The good results from the new method; The poor results from the new methods; Evidence given by the prisoners themselves; Evidence from the prevalence of recidivism; Are the 60 % who do not return, reformed?; Imprisonment as a mode of punishment; Retribution and revenge; The social value of retribution and revenge; The deterrent value of imprisonment; Influence of imprisonment upon the prisoners; and Effects on normal and disordered prisoners. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - value of imprisonment
KW - psychiatric groups
KW - prisoners
KW - rehabilitation
KW - punishment
KW - social benefits
KW - recidivism
KW - 1939
KW - Criminal Rehabilitation
KW - Prisoners
KW - Prisons
KW - Psychosocial Rehabilitation
KW - Mental Disorders
KW - Punishment
KW - Recidivism
KW - Social Issues
KW - 1939
DO - 10.1037/14698-013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2014-49261-000
AN - 2014-49261-000
AU - Wilson, J. G.
AU - Persor, M. J.
T1 - Problems in prison psychiatry.
Y1 - 1939///
CY - Caldwell, ID, US
PB - Caxton Printers
N1 - Accession Number: 2014-49261-000. Partial author list: First Author & Affiliation: Wilson, J. G.; Kentucky Department of Welfare, Division of Hospitals and Mental Hygiene, KY, US. Release Date: 20141229. Correction Date: 20150323. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. Book Type: Classic Book. Language: English. Major Descriptor: Mental Disorders; Mental Health; Prisoners; Prisons; Psychiatry. Minor Descriptor: Correctional Institutions; Criminal Rehabilitation. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 275.
AB - This book attempts to analyze some of the mental health problems or psychiatric aspects of correctional institutional procedure. The authors of this book question by implication whether the present state of scientific knowledge concerning human conduct and behavior is being applied to penal and correctional procedure. A medical service for any penal and correctional system of given jurisdiction must bear a direct relationship to those agencies that minister to the physical and mental health of the general population. The place which correctional institutions and forensic and psychiatric medicine must occupy eventually in such a scheme remains to be determined. A formal recording of the psychiatric problems among prisoners, however, is a step in that general direction, and represents an effort to apply our scientific knowledge in terms of social values. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - correctional procedure
KW - prison psychiatry
KW - human conduct
KW - mental health problems
KW - correctional institutional procedure
KW - psychiatric problems
KW - psychiatric medicine
KW - medical service
KW - correctional institutions
KW - 1939
KW - Mental Disorders
KW - Mental Health
KW - Prisoners
KW - Prisons
KW - Psychiatry
KW - Correctional Institutions
KW - Criminal Rehabilitation
KW - 1939
DO - 10.1037/14698-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-49261-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Dorn, Harold F.
T1 - Research Memorandum on Population Redistribution Within the United States/Research Memorandum on Migration Differentials/Needed Population Research.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1939/02//
VL - 4
IS - 1
M3 - Book Review
SP - 137
EP - 139
SN - 00031224
AB - Reviews several books on demographic research. "Research Memorandum on Population Redistribution Within the United States," by Rupert B. Vance; "Research Memorandum on Migration Differentials," by Dorothy Swaine Thomas; "Needed Population Research," by P.K. Whelpton.
KW - NONFICTION
KW - VANCE, Rupert B.
KW - THOMAS, Dorothy Swaine
KW - WHELPTON, P. K.
KW - RESEARCH Memorandum on Population Redistribution Within the United States (Book)
KW - RESEARCH Memorandum on Migration Differentials (Book)
KW - NEEDED Population Research (Book)
N1 - Accession Number: 12770711; Dorn, Harold F. 1; Affiliations: 1: United States Public Health Service; Issue Info: Feb39, Vol. 4 Issue 1, p137; Subject Term: NONFICTION; Reviews & Products: RESEARCH Memorandum on Population Redistribution Within the United States (Book); Reviews & Products: RESEARCH Memorandum on Migration Differentials (Book); Reviews & Products: NEEDED Population Research (Book); People: VANCE, Rupert B.; People: THOMAS, Dorothy Swaine; People: WHELPTON, P. K.; Number of Pages: 3p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12770711&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Dorn, Harold F.
AU - McDowell, Arthur J.
T1 - THE RELATIONSHIP OF FERTILITY AND LONGEVITY.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1939/04//
VL - 4
IS - 2
M3 - Article
SP - 234
EP - 246
SN - 00031224
AB - The rapid decline in the birth rate of practically all industrial nations, which has become especially noticeable during the past two decades, has directed attention to the course of the birth rate during the entire nineteenth and early part of the twentieth centuries. Due to the general inaccuracy and incompleteness of the records of births and deaths during the past century, it has been necessary to resort to indirect indices of the birth rate during this period. One of these indices is a comparison of the average number of offspring of women dying at various ages alter the close of the childbearing period. On the assumption that there is no relationship between fertility and length of life, the difference in the average number of children born to women aged 50-54 years at death and women aged 80-84 years at death is a measure of the difference in the birth rate of the two periods during which these women were in the childbearing ages. All investigations have shown that women dying at advanced ages have borne on the average more children than women dying at younger ages.
KW - HUMAN fertility
KW - LONGEVITY
KW - LIFE expectancy
KW - VITAL records (Births, deaths, etc.)
KW - SOCIAL indicators
KW - DEVELOPED countries
N1 - Accession Number: 12781593; Dorn, Harold F. 1; McDowell, Arthur J. 1; Affiliations: 1: United States Public Health Service, Washington, D. C.; Issue Info: Apr39, Vol. 4 Issue 2, p234; Subject Term: HUMAN fertility; Subject Term: LONGEVITY; Subject Term: LIFE expectancy; Subject Term: VITAL records (Births, deaths, etc.); Subject Term: SOCIAL indicators; Subject: DEVELOPED countries; Number of Pages: 13p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12781593&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Dorn, Harold F.
T1 - New Facts on Mental Disorders: Study of 89,190 Cases (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1940/06//
VL - 5
IS - 3
M3 - Book Review
SP - 451
EP - 452
SN - 00031224
AB - Reviews the book "New Facts on Mental Disorders: Study of 89,190 Cases," by Neil A. Dayton.
KW - MENTAL illness
KW - NONFICTION
KW - DAYTON, Neil A.
KW - NEW Facts on Mental Disorders: Study of 89,190 Cases (Book)
N1 - Accession Number: 12914531; Dorn, Harold F. 1; Affiliations: 1: United Slates Public Health Service.; Issue Info: Jun40, Vol. 5 Issue 3, p451; Subject Term: MENTAL illness; Subject Term: NONFICTION; Reviews & Products: NEW Facts on Mental Disorders: Study of 89,190 Cases (Book); People: DAYTON, Neil A.; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12914531&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2005-13635-004
AN - 2005-13635-004
AU - Brown, Ralph R.
T1 - Limitations of Group Tests for Classification Purposes.
JF - Journal of Consulting Psychology
JO - Journal of Consulting Psychology
JA - J Consult Psychol
Y1 - 1940/09//
VL - 4
IS - 5
SP - 199
EP - 200
CY - US
PB - Dentan Printing Company
SN - 0095-8891
N1 - Accession Number: 2005-13635-004. Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Brown, Ralph R.; US Public Health Service, US. Other Publishers: American Association for Applied Psychology; American Psychological Association; Science Press Printing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Group Testing. Minor Descriptor: Taxonomies. Classification: Tests & Testing (2220). Page Count: 2. Issue Publication Date: Sep, 1940.
AB - Discusses some of the problems and limitations, as well as a few benefits, of group tests used for classification purposes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - classification purposes
KW - group tests
KW - 1940
KW - Group Testing
KW - Taxonomies
KW - 1940
DO - 10.1037/h0051289
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13635-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY -
AU - Hirsh, Joseph1
T1 - TEXTBOOK OF HEALTHFUL LIVING (Book).
JO - Social Forces
JF - Social Forces
J1 - Social Forces
PY - 1940/12//
Y1 - 1940/12//
VL - 19
IS - 2
CP - 2
M3 - Book Review
SP - 291
EP - 292
SN - 00377732
AB - Reviews the book "Textbook of Healthful Living," by H.S. Diehl.
KW - Nonfiction
KW - Health
KW - Diehl, H. S.
KW - Textbook of Healthful Living (Book)
N1 - Accession Number: 13582496; Authors: Hirsh, Joseph 1; Affiliations: 1: U. S. Public Health Service.; Subject: Textbook of Healthful Living (Book); Subject: Diehl, H. S.; Subject: Health; Subject: Nonfiction; Number of Pages: 2p; Record Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=13582496&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY -
AU - Hirsh, Joseph1
T1 - A NEW COURSE IN THE SOCIAL-STUDIES CURRICULUM FOR COLLEGES AND UNIVERSITIES.
JO - Journal of Educational Sociology
JF - Journal of Educational Sociology
J1 - Journal of Educational Sociology
PY - 1941/05//
Y1 - 1941/05//
VL - 14
IS - 9
CP - 9
M3 - Article
SP - 561
EP - 566
SN - 08853525
AB - The article focuses on social science education in colleges and universities. The accusation has been made repeatedly in recent years that the social sciences are destined to remain descriptive and academic. Methodologists have replied to this accusation by propounding scientific systems. Educators, recognizing the malleability of the social sciences and their interdependence with the changing character, needs, and problems of society, have met this challenge in part by introducing new courses in the social studies into the curriculum. Since this process is still largely exploratory, attention is invited to a consideration of a course on a sociology of medicine in the social-studies divisions of colleges and universities. Today, medical care has become a distinct sphere for practical action. It seems important, therefore, that this action be charted on an intellectual rather than controversial basis as a field of research and teaching. A sociology of medicine demands the study of the technological history of medicine and of its component and related sciences, how they are conditioned and how they in turn affect the costs, organization, and distribution of medical services.
KW - Universities & colleges
KW - Education
KW - Social sciences -- Study & teaching
KW - Instructional systems
KW - Social work education
KW - Medical care
N1 - Accession Number: 15866368; Authors: Hirsh, Joseph 1; Affiliations: 1: Associate Specialist in Health Education, United States Public Health Service.; Subject: Social sciences -- Study & teaching; Subject: Universities & colleges; Subject: Instructional systems; Subject: Social work education; Subject: Medical care; Subject: Education; Number of Pages: 6p; Record Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=15866368&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Karpinos, Bernard D.
T1 - Studies in American Demography (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1941/06//
VL - 6
IS - 3
M3 - Book Review
SP - 439
EP - 440
SN - 00031224
AB - Reviews the book "Studies in American Demography," by Walter F. Willcox.
KW - DEMOGRAPHY
KW - NONFICTION
KW - WILLCOX, Walter F.
KW - STUDIES in American Demography (Book)
N1 - Accession Number: 12596739; Karpinos, Bernard D. 1; Affiliations: 1: National Institute of Health United States Public Health Service.; Issue Info: Jun41, Vol. 6 Issue 3, p439; Thesaurus Term: DEMOGRAPHY; Subject Term: NONFICTION; Reviews & Products: STUDIES in American Demography (Book); People: WILLCOX, Walter F.; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12596739&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Karpinos, Bernard D.
T1 - Bevölkerungsgeschichte Italiens, Zweiter Band (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1941/06//
VL - 6
IS - 3
M3 - Book Review
SP - 441
EP - 441
SN - 00031224
AB - Reviews the book "Bevölkerungsgeschichte Italiens, Zweiter Band," by Karl Julius Beloch.
KW - POPULATION
KW - NONFICTION
KW - BELOCH, Karl Julius
KW - BEVOLKERUNGSGESCHICHTE Italiens, Zweiter Band (Book)
N1 - Accession Number: 12596741; Karpinos, Bernard D. 1; Affiliations: 1: United States Public Health Service National Institute of Health.; Issue Info: Jun41, Vol. 6 Issue 3, p441; Subject Term: POPULATION; Subject Term: NONFICTION; Reviews & Products: BEVOLKERUNGSGESCHICHTE Italiens, Zweiter Band (Book); People: BELOCH, Karl Julius; Number of Pages: 0p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12596741&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Dorn, Harold F.
T1 - Natural Increase and Migration, Greater Cleveland, 1919-1937/Infant Mortality and Economic Status, Cleveland Five-City Area, 1919-1937 (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1941/06//
VL - 6
IS - 3
M3 - Book Review
SP - 442
EP - 442
SN - 00031224
AB - Reviews two books by Howard Whipple Green. "Natural Increase and Migration, Greater Cleveland, 1919-1937," "Infant Mortality and Economic Status, Cleveland Five-City Area, 1919-1937."
KW - NONFICTION
KW - GREEN, Howard Whipple
KW - NATURAL Increase & Migration, Greater Cleveland, 1919-1937 (Book)
KW - INFANT Mortality & Economic Status: Cleveland Five-City Area (Book)
N1 - Accession Number: 12596742; Dorn, Harold F. 1; Affiliations: 1: U. S. Public Health Service.; Issue Info: Jun41, Vol. 6 Issue 3, p442; Subject Term: NONFICTION; Reviews & Products: NATURAL Increase & Migration, Greater Cleveland, 1919-1937 (Book); Reviews & Products: INFANT Mortality & Economic Status: Cleveland Five-City Area (Book); People: GREEN, Howard Whipple; Number of Pages: 2/3p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12596742&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hirsh, Joseph
T1 - Supervision in Public Health Nursing/Hospital Public Relations/The Patient's Dilemma (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1941/08//
VL - 6
IS - 4
M3 - Book Review
SP - 609
EP - 610
SN - 00031224
AB - Reviews various books on public health. "Supervision in Public Health Nursing," by Violet H. Hodgson; "Hospital Public Relations," by Alden B. Mills; "The Patient's Dilemma," by Hugh Cabot.
KW - NONFICTION
KW - HODGSON, Violet H.
KW - MILLS, Alden B.
KW - CABOT, Hugh
KW - SUPERVISION in Public Health Nursing (Book)
KW - HOSPITAL Public Relations (Book)
KW - PATIENT'S Dilemma, The (Book)
N1 - Accession Number: 12543849; Hirsh, Joseph 1; Affiliations: 1: U. S. Public Health Service.; Issue Info: Aug41, Vol. 6 Issue 4, p609; Subject Term: NONFICTION; Reviews & Products: SUPERVISION in Public Health Nursing (Book); Reviews & Products: HOSPITAL Public Relations (Book); Reviews & Products: PATIENT'S Dilemma, The (Book); People: HODGSON, Violet H.; People: MILLS, Alden B.; People: CABOT, Hugh; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12543849&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Dorn, Harold F.
T1 - Tuberculosis and Social Conditions in England: With Special Reference to Young Adults (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1941/08//
VL - 6
IS - 4
M3 - Book Review
SP - 610
EP - 611
SN - 00031224
AB - Reviews the book "Tuberculosis and Social Conditions in England: With Special Reference to Young Adults," by P. D'Arcy and G. Payling Wright.
KW - TUBERCULOSIS
KW - NONFICTION
KW - D'ARCY, P.
KW - WRIGHT, G. Payling
KW - TUBERCULOSIS & Social Conditions in England: With Special Reference to Young Adults: A Statistical Study (Book)
N1 - Accession Number: 12543850; Dorn, Harold F. 1; Affiliations: 1: U. S. Public Health Service.; Issue Info: Aug41, Vol. 6 Issue 4, p610; Subject Term: TUBERCULOSIS; Subject Term: NONFICTION; Reviews & Products: TUBERCULOSIS & Social Conditions in England: With Special Reference to Young Adults: A Statistical Study (Book); People: D'ARCY, P.; People: WRIGHT, G. Payling; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12543850&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2005-11654-002
AN - 2005-11654-002
AU - Lindner, Robert M.
T1 - Review of Measurements of human behavior.
JF - Psychological Bulletin
JO - Psychological Bulletin
JA - Psychol Bull
Y1 - 1941/12//
VL - 38
IS - 10
SP - 992
EP - 993
CY - US
PB - American Psychological Association
SN - 0033-2909
SN - 1939-1455
N1 - Accession Number: 2005-11654-002. Partial author list: First Author & Affiliation: Lindner, Robert M.; U. S. Public Health Service, US. Other Publishers: Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Behavior; Behavioral Assessment; Measurement. Classification: Tests & Testing (2220); Human Experimental Psychology (2300). Population: Human (10). Reviewed Item: Greene, E. B. Measurements of human behavior=New York: Odyssey Press, 1941. Pp. xxi+777; 1941. Page Count: 2. Issue Publication Date: Dec, 1941. Copyright Statement: American Psychological Association. 1941.
AB - Reviews the book 'Measurements of human behavior' by E. B. Greene (see record [rid]1941-04433-000[/rid]). The reviewer states that the expressed intention of the author was to prepare a book in which behavioral measurement techniques and procedures would be treated more comprehensively than they are in available volumes. It is a credit to Professor Greene that such an ambitious project has been realized in a manner that will please the three most interested groups: instructors who are seeking a textbook suitable for the more modern course in measurement; students who have expressed (at least to this writer) their despair with texts which from preface to bibliography credit them with too much in the way of preparation; and clinicians who have long awaited a convenient and descriptive practical guide. The volume is liberally supplied with illustrative material, graphs, charts, and tables. For a refreshing change these appear for the most part on the same pages with expository matter relating to them, thus obviating bothersome turning of pages to find the graphic referrals mentioned in the text. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - measurements
KW - human behavior
KW - behavioral measurement techniques
KW - procedures
KW - 1941
KW - Behavior
KW - Behavioral Assessment
KW - Measurement
KW - 1941
U2 - Greene, E. B. (1941); Measurements of human behavior; New York: Odyssey Press, 1941. Pp. xxi+777
DO - 10.1037/h0052891
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11654-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY -
AU - Karpinos, Bernard D.1
AU - Sommers, Herbert J.1
T1 - EDUCATIONAL ATTAINMENT OF URBAN YOUTH IN VARIOUS INCOME CLASSES. I.
JO - Elementary School Journal
JF - Elementary School Journal
J1 - Elementary School Journal
PY - 1942/05//
Y1 - 1942/05//
VL - 42
IS - 9
CP - 9
M3 - Article
SP - 677
EP - 687
SN - 00135984
AB - The article cites key survey findings on the educational attainment of urban youth in various income classes in the U.S. Research findings indicate a direct correlation between the educational status of the youth from 83 cities in the U.S. to their families' annual income. The issues' implications for elementary education are also cited.
KW - Educational attainment
KW - Income
KW - Education & economics
KW - Elementary education
KW - United States
N1 - Accession Number: 21653996; Authors: Karpinos, Bernard D. 1; Sommers, Herbert J. 1; Affiliations: 1: United States Public Health Service; Subject: Educational attainment; Subject: Income; Subject: Education & economics; Subject: Elementary education; Subject: United States; Number of Pages: 11p; Illustrations: 6 Charts, 2 Graphs; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 2013-41255-009
AN - 2013-41255-009
AU - Brown, Ralph R.
T1 - The effect of morphine upon the Rorschach pattern in post-addicts.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1943/04//
VL - 13
IS - 2
SP - 339
EP - 342
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41255-009. Partial author list: First Author & Affiliation: Brown, Ralph R.; US Public Health Service Hospital, Lexington, KY, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional States; Morphine; Psychometrics; Rorschach Test; Test Administration. Minor Descriptor: Personality Traits. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Wechsler Bellevue Examination; Rorschach Test DOI: 10.1037/t03306-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Apr, 1943.
AB - The present study represents an attempt to secure a picture of the effects of morphine on certain basic patterns of personality as revealed by the Rorschach technique. The test was administered under morphine and non-morphine conditions to twenty-two post-addict patients who had been abstinent from morphine for at least six months. The present findings indicate that the administration of morphine in amounts sufficient to cause euphoria in post-addicts results in an increased capacity for imaginative living. The personality shifts in the direction of introversion in the sense of more inner than outer living. The emotional life is somewhat stimulated, but the energy is directed into channels of phantasy living more than in the direction of attention to outer stimuli. Twenty-two post-addict patients who had been abstinent for at least six months were given injections of morphine in amounts sufficient to produce the effect desired by each patient. The Rorschach test was administered under morphine and non-morphine conditions, with half of the group receiving the first test after morphine administration and the retest a month later under non-morphine conditions. Neurotic signs were reduced by morphine. Signs of intellectual control, organizational energy, and originality were not affected. It therefore appears that under morphine the personality of post-addicts changes in the direction of introversion in the sense of increased phantasy living, with the attention being directed to inner rather than outer stimuli. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - emotional life
KW - morphine
KW - test administration
KW - psychometrics
KW - Rorschach pattern
KW - personality shifts
KW - 1943
KW - Emotional States
KW - Morphine
KW - Psychometrics
KW - Rorschach Test
KW - Test Administration
KW - Personality Traits
KW - 1943
DO - 10.1111/j.1939-0025.1943.tb06002.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41255-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Dorn, Harold F.
T1 - Jewish Population Studies.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1943/06//
VL - 8
IS - 3
M3 - Book Review
SP - 365
EP - 366
SN - 00031224
AB - Reviews the book "Jewish Population Studies," edited by Sophia M. Robinson.
KW - JEWS
KW - NONFICTION
KW - ROBINSON, Sophia M.
KW - JEWISH Population Studies (Book)
N1 - Accession Number: 12766699; Dorn, Harold F. 1; Affiliations: 1: United States Public Health Service; Issue Info: Jun43, Vol. 8 Issue 3, p365; Subject Term: JEWS; Subject Term: NONFICTION; Reviews & Products: JEWISH Population Studies (Book); People: ROBINSON, Sophia M.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2013-41266-013
AN - 2013-41266-013
AU - Sears, Richard
T1 - Motivational factors in aptitude testing.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1943/07//
VL - 13
IS - 3
SP - 468
EP - 492
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41266-013. Partial author list: First Author & Affiliation: Sears, Richard; U S Public Health Service, Training School for Boys, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aptitude Measures; Classrooms; Intelligence Measures; Motivation; Special Education. Minor Descriptor: Performance Tests; Test Scores; Testing; Test Performance. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Healy Pictorial Completion Test; Rorschach Test DOI: 10.1037/t03306-000; Vineland Social Maturity Scale; Stanford-Binet Examination DOI: 10.1037/t00012-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 25. Issue Publication Date: Jul, 1943.
AB - The interpretation of aptitude test scores made by subjects whose affective or attitudinal states at the time of testing are not normal presents a familiar but difficult problem to clinical psychologists. Nobody doubts that emotional upsets can disorganize the higher thinking processes, but even rather severe affective disorders are not always incompatible with high test performance. It is a truism that preoccupation with worries may distract one’s attention from the problem in hand, but not all seemingly preoccupied persons do poorly on tests. When taking a test a person obviously will not show his potential ability if he does not try, but it is often difficult to tell how hard he is trying. The problem has many puzzling complications and ramifications which are significant for clinical practice. The purpose of this paper is to correlate and evaluate the clinically significant data available in regard to this problem, or rather, this group of related problems. The available data deal almost entirely with 'intelligence' testing, but presumably the conclusions are also, to a large extent, applicable to the use of other types of standardized aptitude tests. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - motivational factors
KW - aptitude testing
KW - intelligence tests
KW - test performance
KW - special class
KW - test scores
KW - 1943
KW - Aptitude Measures
KW - Classrooms
KW - Intelligence Measures
KW - Motivation
KW - Special Education
KW - Performance Tests
KW - Test Scores
KW - Testing
KW - Test Performance
KW - 1943
DO - 10.1111/j.1939-0025.1943.tb06014.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41266-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-10207-017
AN - 2006-10207-017
AU - Lewin, Kurt
AU - French, John R. P. Jr.
AU - Hendry, Charles
AU - Deets, Lee Emerson
AU - Zander, Alvin
AU - Lippitt, Ronald
AU - Kuselewitz, David
AU - Murphy, Gardner
ED - Murphy, Gardner
ED - Murphy, Gardner, (Ed)
T1 - The Practicality of Democracy.
T2 - Human nature and enduring peace: Third yearbook for the Society for the Psychological Study of Social Issues.
Y1 - 1945///
SP - 295
EP - 347
CY - Boston, MA, US
PB - Houghton Mifflin Company
N1 - Accession Number: 2006-10207-017. Partial author list: First Author & Affiliation: Lewin, Kurt; Massachusetts Institute of Technology, Cambridge, MA, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Democracy; International Relations; Peace; War. Classification: Social Processes & Social Issues (2900). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 53.
AB - This chapter is a study of the processes of democratic living. We reject a current 'pure economic' interpretation of world trends, to the effect that attitudes regarding war, peace, and international relations must automatically follow the course of present international economic trends. Taking a very different slant, we ask a very different kind of question, namely, How can the common man's passionate desire for democracy at home and between nations, and his practical understanding of his own immediate personal predicament in the face of the institution of war, be used as weapons to give him more realization of the means of achieving local and general democracy? The chapter addresses the following questions: Since the economic and political problems of today are so complex, have we any right to hope that democratic leadership can enable the common man to formulate his own problems, work through to his own answers? What about putting democracy to work on community functions? How can the democratic method be practically instituted in the day-by-day functioning of an industrial plant? What can Americans learn about democracy from the Palestinian co-operative communities? What can we learn from the Hutterites regarding the potentialities of human nature for lasting peace? (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - democracy
KW - international relations
KW - war
KW - peace
KW - 1945
KW - Democracy
KW - International Relations
KW - Peace
KW - War
KW - 1945
DO - 10.1037/11192-017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10207-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 108192127
T1 - Lymphogranuloma venereum.
AU - Koteen H
Y1 - 1945/02//
N1 - Accession Number: 108192127. Language: English. Entry Date: 20120727. Revision Date: 20150712. Publication Type: Journal Article; historical material; pictorial; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2985248R.
KW - Lymphogranuloma Venereum -- Diagnosis
KW - Lymphogranuloma Venereum -- Therapy
KW - Syphilis -- Symptoms
KW - Diagnosis, Differential
KW - Hematologic Tests
KW - Lymphogranuloma Venereum -- Epidemiology
KW - Lymphogranuloma Venereum -- Physiopathology
KW - Nomenclature
SP - 1
EP - 69
JO - Medicine
JF - Medicine
JA - MEDICINE
VL - 24
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0025-7974
AD - United States Public Health Service and the Johns Hopkins University Veneral Disease Research and Post-Graduate Training Center
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=108192127&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1947-03493-001
AN - 1947-03493-001
AU - Gardner, L. Pearl
T1 - An analysis of children's attitudes toward fathers.
JF - The Pedagogical Seminary and Journal of Genetic Psychology
JO - The Pedagogical Seminary and Journal of Genetic Psychology
JA - Pedagog Semin J Genet Psychol
Y1 - 1947///
VL - 70
SP - 3
EP - 28
CY - US
PB - Heldref Publications
SN - 0885-6559
N1 - Accession Number: 1947-03493-001. Other Journal Title: The Journal of Genetic Psychology: Research and Theory on Human Development; The Pedagogical Seminary. Partial author list: First Author & Affiliation: Gardner, L. Pearl; U. S. Public Health Service Dispensary, 4th and D Streets, S.W., Washington 25, D.C. Other Publishers: Taylor & Francis. Release Date: 19471001. Correction Date: 20100823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 26. Issue Publication Date: 1947.
AB - A questionnaire of 45 items concerning attitudes and activities of fathers was given to 388 children of the fifth and sixth grades. There were approximately equal numbers of boys and girls, and fifth and sixth graders. 'Both sexes criticized similar things in the father, but boys were slightly more critical than girls. Children did not express special affection for the parent of opposite sex and agreed in giving the mother double the preference of the father. Both sexes desired no more affection from either parent. Each sex gave more ways in which they would like to resemble the parent of the same sex but rated the parent of opposite sex somewhat higher in disposition and character. Both sexes preferred the mother to the father for services, and extreme preferences was for the parent of like-sex… . Girls did more chores for both parents than boys.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - CHILD
KW - ATTITUDE TOWARD
KW - FATHERS
KW - FATHER
KW - —CHILD
KW - PARENT
KW - CHILD'S ATTITUDE TOWARD
KW - CHILD ATTITUDE TOWARD
KW - CHILDHOOD AND ADOLESCENCE
KW - 1947
KW - No terms assigned
KW - 1947
DO - 10.1080/08856559.1947.10533394
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1947-03493-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1948-02085-001
AN - 1948-02085-001
AU - Goldstein, Marcus S.
T1 - Infants of Mexican descent. 1. Physical status of neonates.
JF - Child Development
JO - Child Development
JA - Child Dev
Y1 - 1947///
VL - 18
SP - 3
EP - 10
CY - United Kingdom
PB - Blackwell Publishing
SN - 0009-3920
SN - 1467-8624
N1 - Accession Number: 1948-02085-001. PMID: 18918306 Other Journal Title: Child Development: Abstracts & Bibliography. Partial author list: First Author & Affiliation: Goldstein, Marcus S.; U.S. Public Health Service, Bethesda, Md. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19480501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 8. Issue Publication Date: 1947.
AB - Mexican neonates born in the United States were compared with those born in Mexico as to body weight, body length, and chest circumference. 16 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NEONATE
KW - PHYSICAL STATUS
KW - MEXICANS
KW - ANTHROPOMETRY
KW - MEXICAN
KW - CHILDHOOD & ADOLESCENCE
KW - 1947
KW - No terms assigned
KW - 1947
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1947-03199-001
AN - 1947-03199-001
AU - Felix, Robert H.
T1 - Mental health approach to juvenile delinquency.
JF - Training School Bulletin
JO - Training School Bulletin
Y1 - 1947///
VL - 44
SP - 17
EP - 25
CY - US
PB - The American Institute for Mental Studies
N1 - Accession Number: 1947-03199-001. PMID: 20297227 Partial author list: First Author & Affiliation: Felix, Robert H.; U. S. Public Health Service, Washington, D. C. Release Date: 19470901. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 9. Issue Publication Date: 1947.
AB - The public health attack on juvenile delinquency involves active research into causes and efficacious methods of treatment, sufficient clinical services for out- and in-patient care, and education of the professions and the public to understand the problem and contribute to its solution. Every agency dealing with children requires personnel who like and respect children, a philosophy based upon children's needs, and an ability to utilize community resources fully. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DELINQUENCY & DELINQUENTS
KW - MENTAL HYGIENE AND
KW - MENTAL HYGIENE
KW - & JUVENILE DELINQUENCY
KW - CRIME AND DELINQUENCY
KW - 1947
KW - No terms assigned
KW - 1947
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1948-02218-001
AN - 1948-02218-001
AU - Ross, Mabel
T1 - The relationship of the National Mental Health Act to the problems of mental deficiency.
JF - American Journal of Mental Deficiency
JO - American Journal of Mental Deficiency
JA - Am J Ment Defic
Y1 - 1947///
VL - 52
SP - 48
EP - 53
CY - US
PB - American Assn on Mental Retardation
SN - 0002-9351
N1 - Accession Number: 1948-02218-001. PMID: 20273377 Other Journal Title: American Journal on Intellectual and Developmental Disabilities; American Journal on Mental Retardation. Partial author list: First Author & Affiliation: Ross, Mabel; U.S. Public Health Service, Washington, D. C. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19480501. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1947.
AB - The provisions of the National Mental Health Act are discussed in respect to research, training and grants to the States. Special emphasis is given to the fact that mental deficiency is an important aspect of the mental health problems of any community. It is felt that research, training and service in the field of mental deficiency can be of immeasurable value to the fields of child psychiatry, community service, hospital planning, and home care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - & MENTAL DEFICIENCY
KW - FEEBLEMINDEDNESS
KW - & NATIONAL MENTAL HEALTH ACT
KW - MENTAL DEFICIENCY
KW - 1947
KW - No terms assigned
KW - 1947
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1948-00692-001
AN - 1948-00692-001
AU - Felix, Robert H.
T1 - The National Mental Health Act; how it can operate to meet a national problem.
JF - Mental Hygiene. New York
JO - Mental Hygiene. New York
Y1 - 1947///
VL - 31
SP - 363
EP - 374
N1 - Accession Number: 1948-00692-001. PMID: 20256577 Partial author list: First Author & Affiliation: Felix, Robert H.; U. S. Public Health Service, Washington, D. C. Release Date: 19480201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300); Psychological & Physical Disorders (3200). Page Count: 12. Issue Publication Date: 1947.
AB - Research of a basic sort will be fostered through grants, through the National Institute of Mental Health in Washington, and through the appointment of research fellows in the various sciences which will contribute to understanding of problems in the realm of mental illness. Training grants will attempt to interest more medical students in psychiatry, to improve undergraduate psychiatric training, and will provide better postgraduate training for specialists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - MENTAL HYGIENE
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - BEHAVIOR DEVIATIONS
KW - 1947
KW - No terms assigned
KW - 1947
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1948-01731-001
AN - 1948-01731-001
AU - Corcoran, Mary E.
T1 - Observations and suggestions for improving the care of mental defectives.
JF - American Journal of Mental Deficiency
JO - American Journal of Mental Deficiency
JA - Am J Ment Defic
Y1 - 1947///
VL - 51
SP - 599
EP - 605
CY - US
PB - American Assn on Mental Retardation
SN - 0002-9351
N1 - Accession Number: 1948-01731-001. PMID: 20267767 Other Journal Title: American Journal on Intellectual and Developmental Disabilities; American Journal on Mental Retardation. Partial author list: First Author & Affiliation: Corcoran, Mary E.; U. S. Public Health Service, Washington, D. C. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19480401. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 7. Issue Publication Date: 1947.
AB - On the basis of a survey conducted in 29 institutions for mental defectives, including public and private institutions, in 12 states of the United States, the author reports the great discrepancy in care provided and conditions maintained. Certain difficulties are found in institutions wherever they are located, such as overcrowding, shortage of trained personnel, lack of equipment and supplies. Among the suggestions for improvement the following are offered: (1) Personnel in sufficient number should be selected for their fitness to do the work. (2) Standards of equipment and supplies are needed. (3) Plans for repairs should be prepared. Every room should be made attractive. (4) Programs of staff education can be planned and established. (5) Public relations should be organized and put into operation. (6) Above all every institution should give critical thought to whether its mode of daily life is fitting the defective to return to the community. Routines and procedures should be analyzed and evaluated from that point of view. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - INSTITUTION
KW - MENTAL DEFECTIVE
KW - POLICIES
KW - FEEBLEMINDEDNESS
KW - INSTITUTIONAL
KW - CARE
KW - MENTAL DEFICIENCY
KW - 1947
KW - No terms assigned
KW - 1947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1948-01731-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - Gen
ID - 9999-14048-000
AN - 9999-14048-000
AU - Knutson, Andie L.
T1 - Personal Security Inventory
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1948///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-14048-000. Partial author list: First Author & Affiliation: Knutson, Andie L.; Federal Security Agency, Public Health Service, Washington, District of Columbia, United States. Release Date: 20121112. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: The items in Part I use dichotomous response options, Part II uses 3-point response options; Part III questions are open-ended.. Language: English. Constructs: Sense of Security; Classification: Attitudes, Interests, Values, and Expectancies (5300). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper; Interview
AB - Purpose: The Personal Security Inventory assesses psychological aspects of security and insecurity in areas of personal striving.
AB - Description: The Personal Security Inventory (Knutson, 1948) was developed for use in a group situation as a paper-and-pencil test, or with some variation, in a direct-interview situation as a public opinion schedule. On the basis of the review of previous studies of value and ego-involvements and the preliminary investigations, it was decided to study personal security relative to ten areas of striving: cultural, social standing, intellectual, economic, sexual, appearances, belongingness, religious, health, and work satisfaction. Concrete formulations of the areas were developed through pretesting. The major areas of striving were used as a framework in developing the fixed alternative questions of the Personal Security Inventory, so that undue weighting of the questionnaire in any single direction was minimized. With the exception of the subjective economic security and religious areas, four questions were asked relative to each major area. Eight items were included in the economic area to permit a better test of certain of the major hypotheses of the study. The ranking of the religious area provided a measure of belief but no attempt was made to measure religious security. The security questions in the Inventory were provided with three response possibilities (Satisfied, Dissatisfied, Don't know). Of these, the positive response (Satisfied) was scored i as 'secure,' and both the negative and the doubtful responses were scored o as 'insecure.' Using this method of scoring, a total security score of 41 was possible. To minimize the influence of item order on responses, two forms of the Inventory were prepared. The only difference between these two forms is the order of the items on page one. In terms of validation, the Inventory was found to discriminate significantly between a psychoneurotic patient group and several occupational groups at a veterans' mental hospital. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Personal Security Inventory
KW - Psychological Adjustment
KW - Psychological Aspects
KW - Security vs Insecurity
KW - Test Development
U5 - Personal Security Inventory [Test Development]Personal security as related to station in life. (AN: 2011-16308-001 from PsycINFO) Knutson, Andie L.; 1952. Source: Psychological Monographs: General and Applied. 66(4), American Psychological Association, US; 1952; Administration: Paper, Interview Age Group: Adulthood (18 yrs & older); Population: Human; Location: United States; Sample: Patient and Occupational Groups Keywords: Personal Security Inventory; Psychological Adjustment; Psychological Aspects; Security vs Insecurity; Test Development; Subjects: Attitude Measures; Emotional Adjustment; Emotional Security; Inventories; Test Construction;
DO - 10.1037/t14048-000
L3 - Full; Full text; 999914048_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - McGibony, J. R.
T1 - GERIATRICS AND PUBLIC HEALTH.
JO - Geriatrics
JF - Geriatrics
Y1 - 1948/01//Jan/Feb1948
VL - 3
IS - 1
M3 - Article
SP - 10
EP - 14
SN - 0016867X
N1 - Accession Number: 17718756; McGibony, J. R. 1,2; Source Information: Jan/Feb1948, Vol. 3 Issue 1, p10; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 1940
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1949-06189-001
AN - 1949-06189-001
AU - Felix, R. H.
AU - Bowers, R. V.
T1 - Mental hygiene and socio-environmental factors.
JF - Milbank Quarterly
JO - Milbank Quarterly
JA - Milbank Q
Y1 - 1948///
VL - 26
SP - 125
EP - 147
CY - United Kingdom
PB - Blackwell Publishing
SN - 0887-378X
SN - 1468-0009
N1 - Accession Number: 1949-06189-001. Partial author list: First Author & Affiliation: Felix, R. H.; U.S. Public Health Service, Washington, D.C. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19491201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 23. Issue Publication Date: 1948.
AB - The role of socio-environmental factors in mental disorders as gleaned from recent literature is briefly reviewed. Suggested research for the future includes: (1) extent of mental disorders; (2) etiology; (3) therapy; (4) prevention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MENTAL HYGIENE
KW - SOCIAL
KW - FACTORS
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1948
KW - No terms assigned
KW - 1948
DO - 10.2307/3348020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-06189-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1949-00177-001
AN - 1949-00177-001
AU - Carter, Jerry W. Jr.
T1 - Critical evaluation of nondirective therapy: co-editor's introduction.
JF - Journal of Clinical Psychology
JO - Journal of Clinical Psychology
JA - J Clin Psychol
Y1 - 1948///
VL - 4
SP - 225
EP - 226
CY - US
PB - John Wiley & Sons
SN - 0021-9762
SN - 1097-4679
N1 - Accession Number: 1949-00177-001. Other Journal Title: In Session: Psychotherapy in Practice. Partial author list: First Author & Affiliation: Carter, Jerry W. Jr.; U. S. Public Health Service, Washington, D. C. Release Date: 19490101. Correction Date: 20130624. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 2. Issue Publication Date: 1948.
AB - This is an introduction to a series of critical articles on nondirective therapy. It raises several questions regarding nondirective therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHOTHERAPY
KW - NON-DIRECTIVE
KW - CRITIQUE
KW - TREATMENT METHODS
KW - 1948
KW - No terms assigned
KW - 1948
DO - 10.1002/1097-4679(194807)4:3<225::AID-JCLP2270040302>3.0.CO;2-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-00177-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1948-04250-001
AN - 1948-04250-001
AU - Wikler, Abraham
AU - Frank, Karl
T1 - Effects of electroshock convulsions on chronic decorticated cats.
JF - Proceedings of the Society for Experimental Biology & Medicine
JO - Proceedings of the Society for Experimental Biology & Medicine
JA - Proc Soc Exp Biol Med
Y1 - 1948///
VL - 67
SP - 464
EP - 468
CY - US
PB - Blackwell Science
SN - 0037-9727
N1 - Accession Number: 1948-04250-001. PMID: 18859985 Partial author list: First Author & Affiliation: Wikler, Abraham; U. S. Public Health Service Hosp., Lexington, Ky. Release Date: 19481001. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Physiological Psychology & Neuroscience (2500). Page Count: 5. Issue Publication Date: 1948.
AB - 6 decorticated cats, 7 to 37 days after surgery, were used to study the effects of single and repeated electrically-induced convulsions. Observations reported include a description of the seizure pattern; record the appearance of apnea and transitory hyperpnea, the early return of righting reflexes, the short-term abolition of the licking reaction, and the temporary abolition of sham-rage to pressure stimulation of the tail. Electroencephalographic patterns during the convulsions were of high voltage and ranged from 2 to 21 in frequency. Histological analysis at autopsy showed no cytological changes attributable to the electric current. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ELECTROSHOCK
KW - BEHAVIOR
KW - DECORTICATED CAT
KW - CONVULSION
KW - NERVOUS SYSTEM
KW - 1948
KW - No terms assigned
KW - 1948
DO - 10.3181/00379727-67-16342
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1948-04250-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1949-00792-001
AN - 1949-00792-001
AU - Gottschalk, Louis A.
T1 - Bibliotherapy as an adjuvant in psychotherapy.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1948///
VL - 104
SP - 632
EP - 637
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1949-00792-001. PMID: 18913430 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Gottschalk, Louis A.; U. S. Public Health Service, Washington, D. C. Release Date: 19490201. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 6. Issue Publication Date: 1948.
AB - The value of bibliotherapy as an aid to other forms of psychotherapy is discussed. Three cases are presented to illustrate the part played by this technique. An extensive bibliography is appended covering the fields of personality disorders in children and adolescents, premarital and marital problems, the unmarried adults, general adult maladjustments, and the climacteric and old age. In addition, a 10-item bibliography pertaining to this paper is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHOTHERAPY
KW - BIBLIOTHERAPY IN
KW - BIBLIOTHERAPY
KW - BIBLIOGRAPHIES
KW - TREATMENT METHODS
KW - 1948
KW - No terms assigned
KW - 1948
DO - 10.1176/ajp.104.10.632
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-00792-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-38237-012
AN - 2013-38237-012
AU - Cason, Hulsey
T1 - The concept of the psychopath.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1948/04//
VL - 18
IS - 2
SP - 297
EP - 308
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-38237-012. PMID: 18908631 Partial author list: First Author & Affiliation: Cason, Hulsey; United States Public Health Service, Lewisburg, PA, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antisocial Behavior; Antisocial Personality Disorder; Personality Traits; Psychopathy. Minor Descriptor: Racial and Ethnic Differences. Classification: Personality Disorders (3217). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Apr, 1948.
AB - This article discusses the concept of the psychopath. The concept of psychopathic personality has been widely used in United States and in Europe, and the psychopath is generally recognized as a critical problem both in and out of institutions. He has continued to be a somewhat elusive problem, and there is still not as much agreement on fundamental points as could be desired. In the present paper an attempt is made to describe the psychopath in connection with primitive drives, antisocial modes of behavior, and the control of primitive antisocial behavior. One of the principal problems of life is to control the primitive antisocial tendencies in a fairly decent and satisfactory manner. The psychopath will be regarded as a person who lacks adequate control of these primitive tendencies, but will be described as a natural, human, and fairly easily recognizable type. If it were possible, it would be of scientific advantage to describe the Psychopath in anatomical and physiological terms, and only as a last resort to emphasize such social factors as the family, economics, religion, sociology, and law. But it is impossible to give a good description in purely anatomical and physiological terms. First consideration will therefore be given to those natural traits and characteristics of the psychopath which are intrinsic in the individual himself; the principal concern will be to describe him in terms of his own characteristics. Psychopathic behavior is usually strongly driven, and much of it occurs without effort. Relatively little is known about natural racial differences in psychopathic personality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathy
KW - personality traits
KW - antisocial behavior
KW - racial differences
KW - 1948
KW - Antisocial Behavior
KW - Antisocial Personality Disorder
KW - Personality Traits
KW - Psychopathy
KW - Racial and Ethnic Differences
KW - 1948
DO - 10.1111/j.1939-0025.1948.tb05088.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-38237-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1949-01464-001
AN - 1949-01464-001
AU - Newman, Sidney H.
AU - Bobbitt, Joseph M.
T1 - The development of entrance tests for the United States Coast Guard Academy.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1948/06//
VL - 32
IS - 3
SP - 248
EP - 254
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 1949-01464-001. PMID: 18867060 Partial author list: First Author & Affiliation: Newman, Sidney H.; U. S. Public Health Service, Washington, D. C. Release Date: 19490301. Correction Date: 20111114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Achievement Measures; Coast Guard Personnel; Aptitude Measures; Entrance Examinations; Military Schools. Classification: Military Psychology (3800). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 1948.
AB - From a group of 700 to 2200 applicants, approximately 150 cadets are selected each year for entrance to the Coast Guard Academy. The present battery of entrance tests is the result of cooperative research begun in 1943, and represents the culmination of gradual changes which have resulted in a new system. The battery includes 20 hours of achievement, aptitude, and ability tests, in addition to psychological interviews. Statistical research studies on the tests are now in progress. 12 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - United States Coast Guard Academy
KW - entrance tests
KW - test development
KW - achievement tests
KW - aptitude tests
KW - ability tests
KW - 1948
KW - Achievement Measures
KW - Coast Guard Personnel
KW - Aptitude Measures
KW - Entrance Examinations
KW - Military Schools
KW - 1948
DO - 10.1037/h0057581
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-01464-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-40438-008
AN - 2013-40438-008
AU - Felix, R. H.
T1 - Mental hygiene and public health.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
Y1 - 1948/10//
VL - 18
IS - 4
SP - 679
EP - 684
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40438-008. PMID: 18100865 Partial author list: First Author & Affiliation: Felix, R. H.; U.S. Public Health Service, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hygiene; Mental Health Services; Program Evaluation; Public Health. Minor Descriptor: Economics; Goals; Mental Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 6. Issue Publication Date: Oct, 1948.
AB - This article provides an overview of the mental hygiene in public health. The vital urgency of association of mental health and public health goal's becomes increasingly apparent every day as world conditions demonstrate more and more the need for a stable and adult approach to the complex social and economic problems. A vigorous program is already under way in three major sections: assistance to states for mental health programs, training mental health personnel and research in mental illness. By adding the Psychiatric public health nurse, the scope of team activity is broadened. In a public health approach to the problem of mental illness, a modification of the traditional team pattern of three is necessary. As a part of their training programs, a number of States are also holding institutes and seminars in mental hygiene for public health nurses, and some are paying their expenses to attend institutes in other states. A few states are planning mental hygiene seminars and brief courses of study for other professional personnel employed by the state. Grants may be used by approved training centers to pay the salaries, in whole or in part, of additional instructors, other teaching personnel, and clerical help; to acquire permanent and expendable training materials; and to provide special lectures and demonstrations for training purposes. (PsycINFO Database Record (c) 2013 APA, all rights reserved)
KW - economic problems
KW - mental health programs
KW - mental illness
KW - public health
KW - health goals
KW - 1948
KW - Hygiene
KW - Mental Health Services
KW - Program Evaluation
KW - Public Health
KW - Economics
KW - Goals
KW - Mental Disorders
DO - 10.1111/j.1939-0025.1948.tb05129.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=2013-40438-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 2013-40438-008
AN - 2013-40438-008
AU - Felix, R. H.
T1 - Mental hygiene and public health.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1948/10//
VL - 18
IS - 4
SP - 679
EP - 684
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-40438-008. PMID: 18100865 Partial author list: First Author & Affiliation: Felix, R. H.; U.S. Public Health Service, Washington, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hygiene; Mental Health Services; Program Evaluation; Public Health. Minor Descriptor: Economics; Goals; Mental Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 6. Issue Publication Date: Oct, 1948.
AB - This article provides an overview of the mental hygiene in public health. The vital urgency of association of mental health and public health goal's becomes increasingly apparent every day as world conditions demonstrate more and more the need for a stable and adult approach to the complex social and economic problems. A vigorous program is already under way in three major sections: assistance to states for mental health programs, training mental health personnel and research in mental illness. By adding the Psychiatric public health nurse, the scope of team activity is broadened. In a public health approach to the problem of mental illness, a modification of the traditional team pattern of three is necessary. As a part of their training programs, a number of States are also holding institutes and seminars in mental hygiene for public health nurses, and some are paying their expenses to attend institutes in other states. A few states are planning mental hygiene seminars and brief courses of study for other professional personnel employed by the state. Grants may be used by approved training centers to pay the salaries, in whole or in part, of additional instructors, other teaching personnel, and clerical help; to acquire permanent and expendable training materials; and to provide special lectures and demonstrations for training purposes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - economic problems
KW - mental health programs
KW - mental illness
KW - public health
KW - health goals
KW - 1948
KW - Hygiene
KW - Mental Health Services
KW - Program Evaluation
KW - Public Health
KW - Economics
KW - Goals
KW - Mental Disorders
KW - 1948
DO - 10.1111/j.1939-0025.1948.tb05129.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-40438-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1949-03735-001
AN - 1949-03735-001
AU - Scheele, Leonard A.
T1 - General principles of the Federal program for mental hygiene.
JF - Mental Hygiene. New York
JO - Mental Hygiene. New York
Y1 - 1949///
VL - 33
SP - 25
EP - 29
N1 - Accession Number: 1949-03735-001. PMID: 18108341 Partial author list: First Author & Affiliation: Scheele, Leonard A.; U. S. Public Health Service, Washington, D. C. Release Date: 19490801. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 5. Issue Publication Date: 1949.
AB - A public health program must provide protection for the population as a whole as well as for the individual. The Federal program assumes that mental illnesses will prove amenable to control on a mass basis. The Public Health Service will coordinate state and local action program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MENTAL HYGIENE
KW - PROGRAM
KW - PUBLIC HEALTH SERVICE
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1949
KW - No terms assigned
KW - 1949
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-03735-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1949-03729-001
AN - 1949-03729-001
AU - Lowry, James V.
T1 - How the National Mental Health Act Works.
JF - Mental Hygiene. New York
JO - Mental Hygiene. New York
Y1 - 1949///
VL - 33
SP - 30
EP - 39
N1 - Accession Number: 1949-03729-001. PMID: 18123278 Partial author list: First Author & Affiliation: Lowry, James V.; U. S. Public Health Service, Washington, D. C. Release Date: 19490801. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 10. Issue Publication Date: 1949.
AB - The purpose of the Act is to assist non-federal agencies in performing activities of research, prevention, and treatment, without control of such activities. Operational activities of the USPHS include the clinical and research facilities of the National Institute of Mental Health and demonstration projects such as the Prince Georges County, Maryland, clinic. Research grants, fellowships, training grants, include support for graduate programs in psychiatry, psychology, psychiatric social work, and psychiatric nursing. Grants for training in psychology in 1948 were $145,600; in 1949 are $230,710. Stipends for clinical psychology in 1948 were $64,833; in 1949 are $95,432. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - MENTAL HYGIENE
KW - PROGRAM
KW - PUBLIC HEALTH SERVICE
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1949
KW - No terms assigned
KW - 1949
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1949-03729-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-04669-001
AN - 1950-04669-001
AU - Kolb, Lawrence C.
T1 - Research and its support under the national Mental Health Act.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1949///
VL - 106
SP - 407
EP - 412
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1950-04669-001. PMID: 15393319 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Kolb, Lawrence C.; U. S. Public Health Service, Washington, D. C. Release Date: 19500901. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1949.
AB - The research program developing under the provisions of the National Mental Health Act is proceeding along 3 broad avenues: research grants-in-aid, research fellowships, and the Research Branch of the National Institute of Mental Health. Certain architectural aspects of the forthcoming clinical center of the National Institutes of Health are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - RESEARCH SUPPORT
KW - BEHAVIOR DEVIATIONS
KW - 1949
KW - No terms assigned
KW - 1949
DO - 10.1176/ajp.106.6.407
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-04669-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-04594-001
AN - 1950-04594-001
AU - Schumacher, Henry C.
T1 - Mental hygiene in public health programs.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1949///
VL - 106
SP - 413
EP - 415
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1950-04594-001. PMID: 15406967 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Schumacher, Henry C.; Public Health Service, San Francisco, Calif. Release Date: 19500901. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 3. Issue Publication Date: 1949.
AB - Regardless of how well trained the health $$$, the clinicians, and the nurses might be in administration, a sound knowledge of mental hygiene and, most of all, an appreciation of the effects of their attitudes and feelings, and those of the patients as expressed in their interpersonal relationships, are needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PUBLIC
KW - HEALTH
KW - & MENTAL
KW - HYGIENE
KW - MENTAL HYGIENE
KW - & PUBLIC HEALTH
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1949
KW - No terms assigned
KW - 1949
DO - 10.1176/ajp.106.6.413
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-04594-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-04383-001
AN - 1950-04383-001
AU - Vestermark, Seymour D.
T1 - Training and its support under the National Mental Health Act.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1949///
VL - 106
SP - 416
EP - 419
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1950-04383-001. PMID: 15393320 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Vestermark, Seymour D.; U. S. Public Health Service, Washington, D. C. Release Date: 19500901. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Professional Psychological & Health Personnel Issues (3400); Psychological & Physical Disorders (3200). Page Count: 4. Issue Publication Date: 1949.
AB - The highlights of the personnel training program during the first 2 years of operation are presented. Possible approaches for extending the training program in the future are considered. The author points to the need of a re-evaluation and definition of the current training programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - TRAINING PROGRAM
KW - PROFESSIONAL PROBLEMS OF PSYCHOLOGY
KW - BEHAVIOR DEVIATIONS
KW - 1949
KW - No terms assigned
KW - 1949
DO - 10.1176/ajp.106.6.416
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-04383-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-02864-001
AN - 1950-02864-001
AU - Cooney, James P.
T1 - Psychological factors in atomic warfare.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 1949///
VL - 39
SP - 969
EP - 973
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 1950-02864-001. PMID: 18137955 Partial author list: First Author & Affiliation: Cooney, James P.; Office of the Surgeon General, Army, Washington, D. C. Release Date: 19500501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 5. Issue Publication Date: 1949.
AB - The author argues that a practical attitude toward the atomic bomb must be acquired by the total population. The psychological problems revolve around fear of the bomb which fear is principally of the radiation effects. Public education must be devoted to dispelling the present fears which are based on ignorance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - WAR
KW - ATOMIC
KW - FEAR OF
KW - WARFARE
KW - PSYCHOLOGICAL ASPECTS
KW - INDUSTRIAL AND OTHER APPLICATIONS
KW - 1949
KW - No terms assigned
KW - 1949
DO - 10.2105/AJPH.39.8.969
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-02864-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-02556-001
AN - 1950-02556-001
AU - Knutson, Andie
T1 - Evaluating A.P.H.A. exhibits.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 1949///
VL - 39
SP - 1027
EP - 1035
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 1950-02556-001. PMID: 18147707 Partial author list: First Author & Affiliation: Knutson, Andie; U. S. Public Health Service, Washington, D. C. Release Date: 19500501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Commerce. Classification: Communication Systems (2700); Industrial & Organizational Psychology (3600). Page Count: 9. Issue Publication Date: 1949.
AB - 'The general purposes of this study were to evaluate the relative effectiveness of the forty-two scientific exhibits on display at the Boston A.P.H.A. meetings, November 8-12, 1948 and to investigate some method for pretesting such exhibits.' Methods of evaluating exhibits and suggestions for improving are presented. A check list and application of the findings conclude the paper. 22-item bibliography. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PUBLIC
KW - HEALTH
KW - EXHIBITS
KW - EVALUATION
KW - EXHIBIT
KW - LANGUAGE & COMMUNICATION
KW - BUSINESS & COMMERCE
KW - 1949
KW - Commerce
KW - 1949
DO - 10.2105/AJPH.39.8.1027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-02556-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY -
AU - Sill, V. R.1
T1 - Sodium Fluoride Goes to School.
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1949/10//
Y1 - 1949/10//
VL - 15
IS - 2
CP - 2
M3 - Article
SP - 14
EP - 16
SN - 0013127X
AB - The article chronicles the discovery of the protective effects of fluoride against tooth decay and the subsequent introduction of sodium fluoride programs in schools and community health centers in the United States. Research determined that the brown discoloration of teeth, a condition that was later termed dental fluorosis, among residents of certain communities in Colorado Springs, Colorado, was caused by unusually high fluoride levels in the drinking water. Consequently, it was discovered that lower concentrations of fluoride might not stain the teeth and, in fact, might protect against tooth decay. Realizing the value of fluoride therapy to dental health, the American Dental Association recommended the introduction of sodium fluoride programs in schools.
KW - Health education
KW - Sodium fluoride
KW - Health promotion
KW - Public health
KW - Medical centers
KW - Mottled enamel
KW - Colorado Springs (Colo.)
KW - Colorado
N1 - Accession Number: 19223980; Authors: Sill, V. R. 1; Affiliations: 1: Information and Education Specialist, Division of Dental Public Health, U. S. Public Health Service; Subject: Health education; Subject: Sodium fluoride; Subject: Health promotion; Subject: Public health; Subject: Medical centers; Subject: Mottled enamel; Subject: Colorado Springs (Colo.); Subject: Colorado; Number of Pages: 3p; Record Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=19223980&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 1951-04870-001
AN - 1951-04870-001
AU - Sacks, J. G.
T1 - Psychological principles and military leadership.
JF - Military Surgeon
JO - Military Surgeon
Y1 - 1950///
VL - 107
SP - 38
EP - 41
N1 - Accession Number: 1951-04870-001. PMID: 15429784 Partial author list: First Author & Affiliation: Sacks, J. G.; Office of the Surgeon General, Army, Washington, D. C. Release Date: 19510701. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 4. Issue Publication Date: 1950.
AB - In order to attain successful leadership it is important to understand the basic principles of human behavior. The military leader must help to see that the social needs of his men are satisfied. Without affection, recognition, social acceptance and a feeling of superiority of self-achievement, men do not make good social adjustments and consequently are usually inefficient soldiers. The maintenance of the mental health of the soldier is a command function and the company commander should be on the alert constantly for symptoms of maladjustment among his men. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MILITARY
KW - LEADERSHIP
KW - PSYCHOLOGY
KW - PERSONNEL PSYCHOLOGY
KW - 1950
KW - No terms assigned
KW - 1950
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-04870-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1950-05241-001
AN - 1950-05241-001
AU - Schumacher, Henry C.
T1 - Nature of mental health programs in health and educational agencies under the National Mental Health Act; the role of a consultant.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 1950///
VL - 40
SP - 131
EP - 135
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 1950-05241-001. PMID: 15402719 Partial author list: First Author & Affiliation: Schumacher, Henry C.; U. S. Public Health Service, San Francisco, Calif. Release Date: 19501001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 5. Issue Publication Date: 1950.
AB - This is a review of the work of the consultant in which the author points out the key points of a training program and the overall need for consultant service aimed toward preventive and treatment. The first step is an effectively integrated program, that is, one which is generally accepted as feasible. This should be followed by adequate training of the staff with the suggestion that in lieu of a competent psychiatrist, a clinical psychologist of proper training and experience, a mature psychiatric social worker, or especially trained nurses may be useful as consultants. The approach for introducing a program of mental hygiene into the public schools is outlined. Comments are made on the use of films illustrating mental hygiene subject matter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - NATIONAL MENTAL HEALTH ACT
KW - MENTAL HYGIENE
KW - PROGRAM
KW - HEALTH & EDUCATION AGENCIES
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1950
KW - No terms assigned
KW - 1950
DO - 10.2105/AJPH.40.2.131
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1950-05241-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1951-01661-001
AN - 1951-01661-001
AU - Birren, James E.
AU - Casperson, Roland C.
AU - Botwinick, Jack
T1 - Age changes in pupil size.
JF - Journal of Gerontology
JO - Journal of Gerontology
JA - J Gerontol
Y1 - 1950///
VL - 5
SP - 216
EP - 221
CY - US
PB - Gerontological Society of America
SN - 0022-1422
N1 - Accession Number: 1951-01661-001. PMID: 15428618 Other Journal Title: The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences. Partial author list: First Author & Affiliation: Birren, James E.; Gerontology Section, Public Health Service, Bethesda, Md. Other Publishers: Oxford University Press. Release Date: 19510301. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800); Human Experimental Psychology (2300). Page Count: 6. Issue Publication Date: 1950.
AB - Photographs were taken of the pupils of 222 subjects from 20 to 89 years of age. Significant reductions in pupil size with age were found in the dark and in a brightness of 1.0 millilambert. The relation between pupil size and age was found to be curvilinear and the equations for predicting pupil size from age are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PUPIL (EYE)
KW - SIZE
KW - & AGE
KW - OLD AGE
KW - PUPIL SIZE
KW - MATURITY & OLD AGE
KW - VISION
KW - 1950
KW - No terms assigned
KW - 1950
DO - 10.1093/geronj/5.3.216
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-01661-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1951-06853-001
AN - 1951-06853-001
AU - Clausen, John A.
T1 - Social science research in the National Mental Health Program.
JF - American Sociological Review
JO - American Sociological Review
JA - Am Sociol Rev
Y1 - 1950///
VL - 15
SP - 402
EP - 409
CY - US
PB - American Sociological Assn
SN - 0003-1224
SN - 1939-8271
N1 - Accession Number: 1951-06853-001. Partial author list: First Author & Affiliation: Clausen, John A.; U. S. Public Health Service, Washington, D. C. Other Publishers: Sage Publications. Release Date: 19511001. Correction Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 8. Issue Publication Date: 1950.
AB - A brief review of the intent of the National Mental Health Act is followed by a description of the part social scientists are now taking in the National Institute of Mental Health. Program research and basic scientific research either projected or in process under the auspices of the institute are described. The author emphasizes the social science research and indicates the need for research outside the program of the institute. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SOCIAL SCIENCE
KW - IN NATL. MENTAL HEALTH PROGRAM
KW - MENTAL HYGIENE
KW - NATIONAL PROGRAM
KW - & SOCIAL SCIENCE
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1950
KW - No terms assigned
KW - 1950
DO - 10.2307/2087183
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-06853-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1951-03984-001
AN - 1951-03984-001
AU - Harris, Frank J.
T1 - Can personality tests identify accident-prone employees?
JF - Personnel Psychology
JO - Personnel Psychology
JA - Pers Psychol
Y1 - 1950///
VL - 3
SP - 455
EP - 459
CY - United Kingdom
PB - Blackwell Publishing
SN - 0031-5826
SN - 1744-6570
N1 - Accession Number: 1951-03984-001. Partial author list: First Author & Affiliation: Harris, Frank J.; U. S. Public Health Service, Washington, D. C. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19510601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 5. Issue Publication Date: 1950.
AB - 'The frequently reported finding that a few individuals in a given group account for a disproportionately large number of accidents has led to the now-respectable hypothesis that such individuals may be 'accident-prone.' This study was an exploratory attempt to determine empirically what personality differences could be measured between a group of 25 industrial-accident repeaters and a group of 25 industrial workers who were accident free. These two groups were carefully selected and matched on practically every relevant respect but one—accident frequency. A number of personality tests were administered to both groups and the results compared statistically. No significant differences were found to exist between the groups in their responses to the test items.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ACCIDENT PRONENESS
KW - & PERSONALITY TESTS
KW - PERSONNEL PSYCHOLOGY
KW - 1950
KW - No terms assigned
KW - 1950
DO - 10.1111/j.1744-6570.1950.tb01719.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1951-03984-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Knutson, Andie L.
T1 - EVALUATION OF EDUCATIONAL FILMS DURING THE PRODUCTION PROCESS.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1950///Spring50
VL - 14
IS - 1
M3 - Article
SP - 144
EP - 145
SN - 0033362X
AB - This article focuses on a study towards the evaluation of educational films during their production process. As mentioned in the article, U.S. Public Health Service has, for a long time, been exploring ways of presenting and evaluating film strips and movies during the production stage. It has applied various pretests in developing eleven film strips on diabetes and one on nutrition. The final test for effectiveness has been carried out on the nutrition film. However, as maintained by the author, the only test for effectiveness must be in terms of the success of the film in achieving the specific objectives for which it was designed, in a situation similar to the one in which it will be used. After revisions on the basis of pretests and production of materials, such a test for effectiveness should be carried out in a control situation on samples of the audience, for which it is being prepared. Moreover, these tests should be made prior to distribution of the film.
KW - Educational films
KW - Filmstrips
KW - Evaluation
KW - Diabetes
KW - Nutrition
KW - United States
KW - United States. Public Health Service
N1 - Accession Number: 11927263; Knutson, Andie L. 1; Affiliations: 1: U.S. Public Health Service.; Issue Info: Spring50, Vol. 14 Issue 1, p144; Thesaurus Term: Educational films; Thesaurus Term: Filmstrips; Subject Term: Evaluation; Subject Term: Diabetes; Subject Term: Nutrition; Subject: United States ; Company/Entity: United States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11927263&site=ehost-live&scope=site
DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 2005-08124-007
AN - 2005-08124-007
AU - Newman, Sidney H.
T1 - Comment: Should Psychological Theory and Practice Be Divided?
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1950/09//
VL - 5
IS - 9
SP - 495
EP - 496
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2005-08124-007. Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service, Washington, DC, US. Release Date: 20050816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Applied Psychology; Clinical Psychology; Clinical Psychology Graduate Training; Psychological Theories; Psychologists. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 2. Issue Publication Date: Sep, 1950. Copyright Statement: American Psychological Association. 1950.
AB - In a recent article entitled 'The Status of Systematic Psychology,' Guthrie proposes 'that psychology be recognized as a basic science and not as a field of practice...' This leads him to raise the question, which supposedly he would answer affirmatively, '... if acceptable to the Medical School, would it be practicable to make the Department of Psychiatry a department of psychiatry and clinical psychology leading to a degree of doctor of clinical psychology for a limited number of persons?' The graduates of this training program would, presumably, engage in the 'practice' of clinical psychology. It seems to me that these proposals would separate psychological theory and practice, 'pure' (basic science) and 'applied' (particularly clinical) psychology, in the training process and in occupational activities. It is my opinion that theory and practice, 'pure' and 'applied' psychology, cannot be separated in training without serious detriment to the student and faculty. Further, they cannot be divided into two distinct occupational lines (teaching, theorizing and/or research versus 'practice') without seriously affecting both endeavors in an adverse manner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological theory
KW - psychological practice
KW - psychologists
KW - clinical psychology
KW - applied psychology
KW - clinical training
KW - 1950
KW - Applied Psychology
KW - Clinical Psychology
KW - Clinical Psychology Graduate Training
KW - Psychological Theories
KW - Psychologists
KW - 1950
DO - 10.1037/h0057353
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08124-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1952-07167-001
AN - 1952-07167-001
AU - Grant, Marjorie
T1 - The group approach for weight control; report of a pilot study in Boston area, 1949-1950.
JF - Group Psychotherapy
JO - Group Psychotherapy
Y1 - 1951///
VL - 4
SP - 156
EP - 165
N1 - Accession Number: 1952-07167-001. Partial author list: First Author & Affiliation: Grant, Marjorie; U. S. Public Health Service, Washington, D. C. Release Date: 19521101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 10. Issue Publication Date: 1951.
AB - The Boston Dispensary at the New England Medical Center undertook a pilot study in group discussion on weight control problems. Sessions lasted one hour per week for sixteen weeks and were under the supervision of a group leader. Medical clearance was obtained for each individual member who determined his own weight goal. Data after a one-year follow up indicates substantial decreases in weight and 'it is the conclusion of the staff that the method of weight control attempted in this study may be a practical and successful measure to meet a difficult problem in public health.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - OBESITY
KW - GROUP PSYCHOTHERAPY
KW - FOR OBESITY
KW - PSYCHOSOMATICS
KW - 1951
KW - No terms assigned
KW - 1951
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1952-07167-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1952-04112-001
AN - 1952-04112-001
AU - Wikler, Abraham
T1 - Clinical aspects of diagnosis and treatment of addictions.
JF - Bulletin of the Menninger Clinic
JO - Bulletin of the Menninger Clinic
JA - Bull Menninger Clin
Y1 - 1951///
VL - 15
SP - 157
EP - 166
CY - US
PB - Guilford Publications
SN - 0025-9284
N1 - Accession Number: 1952-04112-001. PMID: 14869926 Partial author list: First Author & Affiliation: Wikler, Abraham; U. S. Public Health Service Hosp., Lexington, Ky. Release Date: 19520701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 10. Issue Publication Date: 1951.
AB - The diagnosis and treatment of addictions to the opiate-like drugs and the barbiturates are considered. Particular attention is given to the morphine abstinence syndrome and to techniques for withdrawing narcotic drugs. Rehabilitation is more briefly discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DRUG
KW - ADDICTION
KW - DIAGNOSIS & TREATMENT
KW - BEHAVIOR PROBLEMS
KW - 1951
KW - No terms assigned
KW - 1951
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1952-04112-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-12257-006
AN - 2005-12257-006
AU - Odoroff, M. E.
T1 - Rehabilitation of the handicapped: A survey of means and methods.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1951/02//
VL - 35
IS - 1
SP - 83
EP - 84
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 2005-12257-006. Partial author list: First Author & Affiliation: Odoroff, M. E.; Federal Security Agency, Public Health Service, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Physical Disorders; Physical Therapy; Rehabilitation. Classification: Rehabilitation (3380). Population: Human (10). Reviewed Item: Soden, William H. (Ed). Rehabilitation of the handicapped: A survey of means and methods=New York: The Ronald Press Co., 1949. Pp. xiii+399. $5.00; 1949. Page Count: 2. Issue Publication Date: Feb, 1951. Copyright Statement: American Psychological Association. 1951.
AB - Reviews Rehabilitation of the handicapped: A survey of means and methods (1949), edited by William H. Soden. This volume contains 38 articles, 21 of which are devoted to some aspect of medical rehabilitation, classified under the headings of general medical and surgical techniques, neurological methods, and psychiatric developments. The remaining 17 articles are distributed under 2 rubrics; vocational and social rehabilitation and educational and psychological trends. Two articles in the medical group discuss the role of nursing in psychosurgery and psychiatric rehabilitation and two more are general discussions of the rehabilitation of those with polio and tuberculosis. All others are technical papers discussing specific medical treatments primarily of interest to specialists. Important segments of the rehabilitation field, however, have not been adequately covered, including counseling, vocational guidance, vocational training and selective job-placement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rehabilitation
KW - physically handicapped
KW - 1951
KW - Physical Disorders
KW - Physical Therapy
KW - Rehabilitation
KW - 1951
U2 - Soden, William H. (Ed). (1949); Rehabilitation of the handicapped: A survey of means and methods; New York: The Ronald Press Co., 1949. Pp. xiii+399. $5.00
DO - 10.1037/h0051378
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12257-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-38642-003
AN - 2013-38642-003
AU - Felix, R. H.
T1 - Mental hygiene as public health practice.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1951/10//
VL - 21
IS - 4
SP - 707
EP - 716
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-38642-003. PMID: 14885383 Partial author list: First Author & Affiliation: Felix, R. H.; National Institute of Mental Health, Public Health Service, Federal Security Agency, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hygiene; Mental Health; Pathology; Psychiatry; Public Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 10. Issue Publication Date: Oct, 1951.
AB - The conviction that psychiatry can contribute to human welfare by working through public health techniques and agencies, as well as through the other medical channels has gained increased acceptance during the past decade. This increased acceptance has come not only on the part of the clinicians, but also on the part of health administrators and the general public. Today, we find a broad and real interest in psychiatry and an impressive demand for mental hygiene services. We can also see the evolution of a practical philosophical framework upon which mental hygiene programs are being built, and we now have at hand a number of promising public health techniques which have been adapted to mental hygiene needs. However, under any conditions the growth of mental hygiene work will continue. Furthermore, it will always be a movement through which psychiatry will be able to emphasize and demonstrate its basic teachings: that health is a totality of physical, emotional and social well-being. Stressing the positive, rather than the pathological, it aims to help people live more effectively, more productively, more in harmony with themselves and their fellows. These objectives are ambitious and far-reaching, but in his work the psychiatrist has many able and enthusiastic allies in other professions and among the public. Working together, we can be confident that these goals will be attained. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - enthusiastic allies
KW - human welfare
KW - mental hygiene programs
KW - mental hygiene services
KW - public health practice
KW - pathology
KW - 1951
KW - Hygiene
KW - Mental Health
KW - Pathology
KW - Psychiatry
KW - Public Health
KW - 1951
DO - 10.1111/j.1939-0025.1951.tb00023.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-38642-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-21642-018
AN - 2006-21642-018
AU - Hastorf, A. H.
AU - Knutson, A. L.
ED - Kilpatrick, Franklin P.
ED - Kilpatrick, Franklin P., (Ed)
T1 - The Nature of Attitude and Opinion.
T2 - Human behavior from the transactional point of view.
Y1 - 1952///
SP - 233
EP - 237
CY - Washington, DC, US
PB - US Dept of Navy
N1 - Accession Number: 2006-21642-018. Partial author list: First Author & Affiliation: Hastorf, A. H.; Psychology Department, Dartmouth College, Hanover, NH, US. Release Date: 20061218. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Attention; Attitudes; Life Experiences; Social Interaction; Social Psychology. Minor Descriptor: Motivation. Classification: Personality Traits & Processes (3120). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 5.
AB - Perception is a central problem in social psychology. In this paper attention is drawn to the manner in which past experience and motivation influence perception in social situations, and, in this way, influence our social attitudes. Any study of attitudes must take into account the fact that attitudes have a functional value, and that a person perceives social situations in terms of his own past experiences, values, and purposes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attitude
KW - opinion
KW - perception
KW - social situations
KW - past experiences
KW - values
KW - purposes
KW - motivation
KW - 1952
KW - Attention
KW - Attitudes
KW - Life Experiences
KW - Social Interaction
KW - Social Psychology
KW - Motivation
KW - 1952
DO - 10.1037/11319-018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21642-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-16308-001
AN - 2011-16308-001
AU - Knutson, Andie L.
T1 - Personal security as related to station in life.
JF - Psychological Monographs: General and Applied
JO - Psychological Monographs: General and Applied
JA - Psychol Monogr
Y1 - 1952///
VL - 66
IS - 4
SP - i
EP - 31
CY - US
PB - American Psychological Association
SN - 0096-9753
N1 - Accession Number: 2011-16308-001. Other Journal Title: Psychological Monographs; The Psychological Monographs; The Psychological Review: Monograph Supplements. Partial author list: First Author & Affiliation: Knutson, Andie L.; Federal Security Agency, Public Health Service, Washington, DC, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20111003. Correction Date: 20121126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Security; Military Veterans; Psychiatric Hospitals. Minor Descriptor: Psychology; Health Personnel. Classification: Inpatient & Hospital Services (3379); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Personal Security Inventory DOI: 10.1037/t14048-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Issue Publication Date: 1952. Publication History: Accepted Date: Jul 2, 1951. Copyright Statement: American Psychological Association, Inc. 1952.
AB - The general purpose of this study was to investigate the nature of personal security to determine what it means psychologically, and to gain some insights about correlates of personal security preliminary concept of security was formulated and was used as the framework in constructing a Personal Security Inventory. The Inventory was then administered to a sample of employees in a veterans' mental hospital and to a group of patients who had been classified by psychologists and psychiatrists as psychoneurotic. It was also administered to a group of students in psychology and to a smaller group of employees of a social welfare agency in New York City. A person's feelings of security or insecurity involve his own subjective evaluation of his success, satisfaction, and surety or confidence with respect to carrying out his purposes in past and present situations and group relationships; also, his expectations, hopes, fears, or uncertainties about the carrying out of his purposes and aspirations in future situations and group relationships. There are functional areas within which people feel secure or insecure, and unique patterns of security exist within even a fairly homogeneous employee population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - personal security
KW - psychology
KW - employees
KW - veterans
KW - mental hospitals
KW - 1952
KW - Emotional Security
KW - Military Veterans
KW - Psychiatric Hospitals
KW - Psychology
KW - Health Personnel
KW - 1952
DO - 10.1037/h0093605
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-16308-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1953-05128-001
AN - 1953-05128-001
AU - Dolan, Dorothea L.
T1 - The educational role of psychiatric social work in community relations.
JF - Journal of Psychiatric Social Work
JO - Journal of Psychiatric Social Work
Y1 - 1952///
VL - 21
SP - 71
EP - 78
N1 - Accession Number: 1953-05128-001. Partial author list: First Author & Affiliation: Dolan, Dorothea L.; U.S. Public Health Service, Chicago, Ill. Release Date: 19530701. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 8. Issue Publication Date: 1952.
AB - This paper discusses the role of the psychiatric social worker in broad community relationships as it has developed through increasing public interest in mental health. The author points up the differences in interpretation to the public, information giving, and education for mental health. 16 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SOCIAL WORK
KW - PSYCHIATRIC
KW - IN COMMUNITY
KW - RELATIONS
KW - METHODOLOGY
KW - TECHNIQUES
KW - 1952
KW - No terms assigned
KW - 1952
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-05128-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1953-05129-001
AN - 1953-05129-001
AU - Doyle, Helen E.
T1 - Implications from the viewpoint of practice in the field of mental health.
JF - Journal of Psychiatric Social Work
JO - Journal of Psychiatric Social Work
Y1 - 1952///
VL - 21
SP - 99
EP - 102
N1 - Accession Number: 1953-05129-001. Partial author list: First Author & Affiliation: Doyle, Helen E.; U.S. Public Health Service, Kansas City, Mo. Release Date: 19530701. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 4. Issue Publication Date: 1952.
AB - This is a discussion of Tessie D. Berkman's paper (see 27: 5125). Comments are based on 'the relationships existing between psychiatric agencies and mental health agencies, and on the training common to psychiatric social workers in both types of resources.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SOCIAL WORK
KW - PSYCHIATRIC
KW - IN MENTAL
KW - HEALTH AGENCIES
KW - METHODOLOGY
KW - TECHNIQUES
KW - 1952
KW - No terms assigned
KW - 1952
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-05129-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1953-05226-001
AN - 1953-05226-001
AU - Peterson, Donald B.
AU - Chambers, Rawley E.
T1 - Restatement of combat psychiatry.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1952///
VL - 109
SP - 249
EP - 254
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1953-05226-001. PMID: 12976544 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Peterson, Donald B.; Office of the Surgeon General, Washington, D.C. Release Date: 19530701. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1952.
AB - Certain facets of combat psychiatry operative in the Korean conflict are discussed including American cultural background, psychiatric screening, manpower, introgenicity, motivation, primary gain, the nature of war neurosis, and therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHIATRY
KW - MILITARY COMBAT
KW - MILITARY
KW - COMBAT
KW - PSYCHIATRY IN
KW - BEHAVIOR DEVIATIONS
KW - 1952
KW - No terms assigned
KW - 1952
DO - 10.1176/ajp.109.4.249
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-05226-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1953-05625-001
AN - 1953-05625-001
AU - Hill, Harris E.
AU - Flanary, Harold G.
AU - Kornetsky, Conan H.
AU - Wikler, Abraham
T1 - Relationship of electrically induced pain to the amperage and the wattage of shock stimuli.
JF - Journal of Clinical Investigation
JO - Journal of Clinical Investigation
Y1 - 1952///
VL - 31
SP - 464
EP - 472
N1 - Accession Number: 1953-05625-001. PMID: 14927737 Partial author list: First Author & Affiliation: Hill, Harris E.; Public Health Service Hosp., Lexington, Ky. Release Date: 19530801. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Human Experimental Psychology (2300). Page Count: 9. Issue Publication Date: 1952.
AB - The wiring circuit is described for an apparatus for controlling either the delivery wattage or the delivery amperage of electrical stimuli of fixed duration. The power developed by a particular voltage in a biological circuit of a given resistance did not correspond to that in a physical circuit with the same characteristics. It is demonstrated that the delivery wattage correlates more highly than amperage with subjective estimation of the intensities of electric shock stimuli. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PAIN
KW - ELECTRIC
KW - AMPERAGE VS. WATTAGE
KW - ELECTRICITY
KW - BIOLOGICAL VS. PHYSICAL CIRCUIT
KW - RECEPTIVE AND PERCEPTUAL PROCESSES
KW - 1952
KW - No terms assigned
KW - 1952
DO - 10.1172/JCI102631
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-05625-001&site=ehost-live&scope=site
UR - ORCID: 0000-0003-2474-6993
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1953-05993-001
AN - 1953-05993-001
AU - Hill, Harris E.
AU - Flanary, Harold G.
AU - Kornetsky, Conan H.
AU - Wikler, Abraham
T1 - Effects of anxiety and morphine on discrimination of intensities of painful stimuli.
JF - Journal of Clinical Investigation
JO - Journal of Clinical Investigation
Y1 - 1952///
VL - 31
SP - 473
EP - 480
N1 - Accession Number: 1953-05993-001. PMID: 14927738 Partial author list: First Author & Affiliation: Hill, Harris E.; Public Health Service Hosp., Lexington, Ky. Release Date: 19530801. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200); Human Experimental Psychology (2300). Page Count: 8. Issue Publication Date: 1952.
AB - The experiment was designed to discover the effect of morphine on estimates of pain threshold under experimental conditions differing in anxiety-producing characteristics. A total of 42 post-addicts served as subjects with the pain stimulus being an electric shock. It was found that under conditions promoting anxiety or fear of pain, subjects tended to overestimate the intensities of painful stimuli. Morphine reduced such anxiety. Under conditions in which anxiety was largely eliminated, there was little estimation of intensities and morphine had no effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PAIN
KW - INTENSITY
KW - MORPHINE & ANXIETY
KW - MORPHINE
KW - & PAIN
KW - STIMULI
KW - DRUGS
KW - ANXIETY
KW - & PAIN STIMULI
KW - BEHAVIOR PROBLEMS
KW - RECEPTIVE AND PERCEPTUAL PROCESSES
KW - 1952
KW - No terms assigned
KW - 1952
DO - 10.1172/JCI102632
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1953-05993-001&site=ehost-live&scope=site
UR - ORCID: 0000-0003-2474-6993
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1952-06112-001
AN - 1952-06112-001
AU - Wikler, Abraham
T1 - Mechanisms of action of drugs that modify personality function.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1952///
VL - 108
SP - 590
EP - 599
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1952-06112-001. PMID: 14903185 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Wikler, Abraham; U. S. Public Health Service Hosp., Lexington, Ky. Release Date: 19521001. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Personality Psychology (3100); Psychological & Physical Disorders (3200). Page Count: 10. Issue Publication Date: 1952.
AB - The mechanisms through which drugs modify personality 'in terms of subjective experience, overt performance and neurophysiology' are critically examined. Certain general conclusions are derived regarding the incommensurability of 'subjective' and 'objective' data, organism-environment and the nature of a stimulus. They are reconciled with a monistic theory of 'mind' and 'body.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PERSONALITY
KW - DRUG INFLUENCES
KW - DRUG
KW - EFFECTS
KW - ON PERSONALITY
KW - PSYCHOSES
KW - 1952
KW - No terms assigned
KW - 1952
DO - 10.1176/ajp.108.8.590
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1952-06112-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY -
AU - DeLoach, Will S.1,2
AU - Hall, Auburn Russ1,3
T1 - TIME AND PLACE OF UNDERGRADUATE TRAINING OF A GROUP OF HIGH SCHOOL CHEMISTRY TEACHERS.
JO - Science Education
JF - Science Education
J1 - Science Education
PY - 1952/03//
Y1 - 1952/03//
VL - 36
IS - 2
CP - 2
M3 - Article
SP - 90
EP - 91
SN - 00368326
AB - The article reports on the results of a study of the academic training chemistry teachers of public and private white high schools in Alabama for the year 1948-1949 to determine when and where they had their undergraduate training. Of the 192 teachers for whom the information was available, 95 were women and 97 were men. Some comparisons were made as to time and place of training in order to see if there was much difference in the preparation of the men and women teachers. It was found that there were no great differences in the date of graduation except during the World War II period when more women graduated.
KW - Chemistry teachers
KW - Science teachers
KW - Teacher education
KW - High school teachers
KW - Women teachers
KW - High school teaching
KW - Undergraduate programs
KW - Higher education
KW - Alabama
N1 - Accession Number: 19087529; Authors: DeLoach, Will S. 1,2; Hall, Auburn Russ 1,3; Affiliations: 1: Huntingdon College, Montgomery, Alabama; 2: Mississippi State College for Women, Columbus, Miss.; 3: U. S. Public Health Service Virus and Rickettsia Laboratory, Montgomery, Ala.; Subject: Chemistry teachers; Subject: Science teachers; Subject: Teacher education; Subject: High school teachers; Subject: Women teachers; Subject: High school teaching; Subject: Undergraduate programs; Subject: Higher education; Subject: Alabama; Number of Pages: 2p; Illustrations: 4 Charts; Record Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=19087529&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Clausen, John A.
T1 - The American Veteran Back Home.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1952/04//
VL - 17
IS - 2
M3 - Book Review
SP - 249
EP - 250
SN - 00031224
AB - Reviews the book "The American Veteran Back Home," by Robert J. Havighurst, Walter H. Eaton, John W. Baughman and Ernest W. Burgess.
KW - VETERANS -- United States
KW - NONFICTION
KW - HAVIGHURST, Robert J. (Robert James), 1900-1991
KW - BURGESS, Ernest W.
KW - EATON, Walter H.
KW - BAUGHMAN, John W.
KW - AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book)
N1 - Accession Number: 12770758; Clausen, John A. 1; Affiliations: 1: National Institute of Mental Health U. S. Public Health Service; Issue Info: Apr52, Vol. 17 Issue 2, p249; Subject Term: VETERANS -- United States; Subject Term: NONFICTION; Reviews & Products: AMERICAN Veteran Back Home: A Study of Veteran Readjustment, The (Book); People: HAVIGHURST, Robert J. (Robert James), 1900-1991; People: BURGESS, Ernest W.; People: EATON, Walter H.; People: BAUGHMAN, John W.; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12770758&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Devlin, Winifred
T1 - The Industrial Nurse and the Older Worker.
JO - Geriatrics
JF - Geriatrics
Y1 - 1953/01//
VL - 8
IS - 1
M3 - Article
SP - 41
EP - 45
SN - 0016867X
N1 - Accession Number: 17692107; Devlin, Winifred 1; Source Information: Jan1953, Vol. 8 Issue 1, p41; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 2735
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17692107&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - CHAP
ID - 2009-05839-006
AN - 2009-05839-006
AU - Meader, Ralph G.
ED - Bush, George P.
ED - Hattery, Lowell H.
ED - Bush, George P., (Ed)
ED - Hattery, Lowell H., (Ed)
T1 - Sponsoring organized university research.
T2 - Teamwork in research.
Y1 - 1953///
SP - 46
EP - 57
CY - Washington, DC, US
PB - American University Press
N1 - Accession Number: 2009-05839-006. Partial author list: First Author & Affiliation: Meader, Ralph G.; Grants and Fellowship Branch, National Cancer Institute, U. S. Public Health Service, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Colleges; Education; Research and Development. Classification: Research Methods & Experimental Design (2260); Educational Psychology (3500). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 12.
AB - The words 'organization' and 'administration' do not always have happy and respected connotations in the minds of investigators. Organizing and administering scientific research implies that there is something to be organized and administered. Actually, it implies planning and carrying out the selection of appropriate personnel, the selection and formulation of research to be done by the personnel, the selection of the methods to be used, the provision of physical and technical facilities necessary for the problem and the personnel concerned, the interpretation of the data obtained and the publication of new contributions to knowledge. Obviously, the most important of these ingredients is the selection of the appropriate personnel for if you have good investigators, they will have good ideas for research and know or develop adequate and appropriate methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - organized university research
KW - research & development
KW - 1953
KW - Colleges
KW - Education
KW - Research and Development
KW - 1953
DO - 10.1037/13368-006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2009-05839-012
AN - 2009-05839-012
AU - Siepert, Albert F.
ED - Bush, George P.
ED - Hattery, Lowell H.
ED - Bush, George P., (Ed)
ED - Hattery, Lowell H., (Ed)
T1 - Auxiliary services as aids to laboratory research.
T2 - Teamwork in research.
Y1 - 1953///
SP - 104
EP - 125
CY - Washington, DC, US
PB - American University Press
N1 - Accession Number: 2009-05839-012. Partial author list: First Author & Affiliation: Siepert, Albert F.; National Institutes of Health, U. S. Public Health Service, Federal Security Agency, US. Release Date: 20100927. Correction Date: 20110912. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Major Descriptor: Experimentation; Research and Development. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 22.
AB - Auxiliary services in a research program embrace all the technical and administrative activities which deal with furnishing men, money, and materials except those under the personal direction of the bench scientist or his immediate staff. The competence of the research staff is the biggest single factor in achieving high calibre research. But the effectiveness of supporting services can often make, or break, the physical and intellectual environment which competent investigators seek for good research. The maintenance of an environment which stimulates good research is a primary goal for any research administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - auxiliary services
KW - laboratory research
KW - 1953
KW - Experimentation
KW - Research and Development
KW - 1953
DO - 10.1037/13368-012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05839-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2007-00281-011
AN - 2007-00281-011
AU - Remmers, H. H.
AU - Weltman, Naomi
AU - Radke-Yarrow, Marian
AU - Miller, Jean Sutherland
AU - Bettelheim, Bruno
AU - Janowitz, Morris
ED - Seidman, Jerome M.
ED - Seidman, Jerome M., (Ed)
T1 - Social Attitudes and Opinions.
T2 - The adolescent: A book of readings.
T3 - The Dryden Press publications in interpersonal relations
Y1 - 1953///
SP - 319
EP - 359
CY - Ft Worth, TX, US
PB - Dryden Press
N1 - Accession Number: 2007-00281-011. Partial author list: First Author & Affiliation: Remmers, H. H.; Purdue University, Bureau of Educational Reference, West Lafayette, IN, US. Release Date: 20070129. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Textbook/Study Guide. Language: English. Major Descriptor: Adolescent Attitudes; Adolescent Development; Minority Groups; Social Cognition; Social Perception. Minor Descriptor: Age Differences; Internal External Locus of Control; Military Veterans; Parents; Racial and Ethnic Groups; Racial and Ethnic Attitudes; Social Identity; Teachers. Classification: Psychosocial & Personality Development (2840); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Intended Audience: Psychology: Professional & Research (PS). Page Count: 41.
AB - This chapter is devoted to the social attitudes and opinions of adolescents. In 'Attitude Interrrelationships of Youth, Their Parents, and Their Teachers,' H. H. Remmers and Naomi Weltman studied the attitudes of high-school youth, their parents, and their teachers and found that the degree of similarity in attitude depends upon the specific attitude. They also noted that the attitudes of older adolescents resembled those of their parents less than did the attitudes of younger adolescents, thus suggesting that schooling maybe have a cumulative effect that becomes more pronounced in older age groups, whereas the reverse holds in the case of parents. (From Journal of Social Psychology, 1947, 26, 61-68. Reprinted by permission of the authors and of The Journal Press.) In 'Children's Concepts and Attitudes about Minority and Majority American Groups,' Marian Radke-Yarrow and Jean Sutherland Miller examined school children in grades 5 through 12 to examine the meanings adolescents attach to such groups as American, Jews, and Negros and to determine the sources of these concepts. (From Journal of Educational Psychology, 1949, 40,449-468. Reprinted by permission of the authors and of Warwick and York, Inc.) In 'Ethnic Tolerance: A Function of Social and Personal Control,' Bruno Bettelheim and Morris Janowitz examined the social attitudes of World War II veterans. The socioeconomic characteristics of World War II veterans fail to explain why some of them are hostile toward minority groups. A significant relationship, however, is found between their hostility and their social mobility, as well as their feelings of deprivation, but not their objective deprivation, such as length of army service or wounds received. (From American Journal of Sociology, 1949, 55, 137-145. Reprinted by permission of the authors and of The University of Chicago Press.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social attitudes
KW - social opinions
KW - social perception
KW - social cognition
KW - WW II veterans
KW - ethnic minorities
KW - tolerance
KW - parents
KW - teachers
KW - age differences
KW - minority groups
KW - personal control
KW - 1953
KW - Adolescent Attitudes
KW - Adolescent Development
KW - Minority Groups
KW - Social Cognition
KW - Social Perception
KW - Age Differences
KW - Internal External Locus of Control
KW - Military Veterans
KW - Parents
KW - Racial and Ethnic Groups
KW - Racial and Ethnic Attitudes
KW - Social Identity
KW - Teachers
KW - 1953
DO - 10.1037/11402-011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00281-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1954-06125-001
AN - 1954-06125-001
AU - Minear, Verna
T1 - An initial venture in the use of television as a medium for psychodrama.
JF - Group Psychotherapy
JO - Group Psychotherapy
Y1 - 1953///
VL - 6
SP - 115
EP - 117
N1 - Accession Number: 1954-06125-001. Partial author list: First Author & Affiliation: Minear, Verna; Public Health Service, Washington, D. C. Release Date: 19540701. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 3. Issue Publication Date: 1953.
AB - Station WTOP in Washington, D. C. televised a psychodrama session for the first time on April 19, 1953. The original program, difficulties, procedure, players, and scenes are briefly described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - TELEVISION
KW - OF PSYCHODRAMA
KW - PSYCHODRAMA
KW - USE OF
KW - TREATMENT METHODS
KW - 1953
KW - No terms assigned
KW - 1953
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1954-06125-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Felix, R. H.
AU - Clausen, John A.
T1 - The Role of Surveys in Advancing Knowledge in the Field of Mental Health.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1953///Spring53
VL - 17
IS - 1
M3 - Article
SP - 61
EP - 70
SN - 0033362X
AB - In this article, authors describe components of a national mental health program and ways in which survey data can be useful to those who are charged with directing such programs in the U.S., as of March 1, 1953. In order to establish effective programs, public health administrators need to know about the extent of the problem with which they deal. There are several aspects to this need. The problem includes not only the number of people who are ill, the nature of their illness and the development and financing of services for treatment or for preventive programs, but also orientations that people have towards using these services that are available to them. Surveys can be very helpful in increasing knowledge of all these aspects of the problem. Research workers in the field of public opinion have developed a high degree of skill in defining and in reaching populations and samples of respondents, they have established some variables, which relate to the validity of responses secured in interviews.
KW - Public opinion
KW - METHODOLOGY
KW - Mental health laws
KW - Public health administration
KW - Mental health services -- Finance
KW - Social surveys -- Response rate
KW - Social sciences
KW - United States
N1 - Accession Number: 11929415; Felix, R. H. 1; Clausen, John A. 2; Affiliations: 1: Director of the National Institute of Mental Health of the Public Health Service.; 2: John Clausen is Chief of the Laboratory of Socio-environmental Studies of the same institute.; Issue Info: Spring53, Vol. 17 Issue 1, p61; Thesaurus Term: Public opinion; Thesaurus Term: METHODOLOGY; Subject Term: Mental health laws; Subject Term: Public health administration; Subject Term: Mental health services -- Finance; Subject Term: Social surveys -- Response rate; Subject Term: Social sciences; Subject: United States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 2005-07816-001
AN - 2005-07816-001
AU - Amrine, Michael
AU - Fernberger, Samuel W.
AU - Komisar, David D.
AU - Newman, Sidney H.
AU - O'Neil, W. M.
AU - Ross, Sherman
AU - Russell, Roger W.
AU - Snyder, Dorothy
AU - Ten Have, Tonko T.
T1 - Convention Impressions.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1953/04//
VL - 8
IS - 4
SP - 151
EP - 164
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2005-07816-001. Partial author list: First Author & Affiliation: Amrine, Michael; University of Pennsylvania, Philadelphia, PA, US. Release Date: 20050816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Psychologists; Scientific Communication. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 14. Issue Publication Date: Apr, 1953. Copyright Statement: American Psychological Association. 1953.
AB - During and after an APA convention a favorite topic of conversation among psychologists is the convention itself, the annual gathering is a high point in the life of many psychologists. We thought it would be interesting--and maybe even useful--to psychologists to collect written impressions of the meetings and publish them for all to see. Accordingly we solicited essays from a number of people, each of whom we thought would view the convention through a different pair of spectacles. We did not succeed in getting all the pieces we asked for, and some of those we received did not have the flavor we predicted, but the final array is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - convention impressions
KW - psychologists
KW - APA convention
KW - 1953
KW - Psychologists
KW - Scientific Communication
KW - 1953
DO - 10.1037/h0061231
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07816-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-38637-013
AN - 2013-38637-013
AU - Maddux, James F.
T1 - Psychiatric consultation in a rural setting.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1953/10//
VL - 23
IS - 4
SP - 775
EP - 784
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Maddux, James F., U.S. Public Health Service, Region 7, Kansas City, MO, US
N1 - Accession Number: 2013-38637-013. PMID: 13104623 Partial author list: First Author & Affiliation: Maddux, James F.; U.S. Public Health Service, Kansas City, MO, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Professional Consultation; Psychodynamic Psychotherapy; Rural Environments; Social Workers. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 1953.
AB - This paper reports an experiment in providing psychiatric consultation over a period of two years to a group of health and welfare workers in a rural setting where no diagnostic and treatment resources were available, and where no community psychiatric service had ever existed. 'Rural' is arbitrarily used here in the sense of complete absence of local psychiatric resources, rather than in accordance with usage of the Bureau of the Census. In the description of the results of this series of meetings, one gets the impression that definite forward steps have been taken in the direction of better understanding of individual cases and greater mutual respect for the work of other disciplines. Some persons will not agree with the idea of consultation about personal problems, but in my opinion this is an essential courtesy, and refusal will unnecessarily antagonize the person who makes the request. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric consultation
KW - psychiatric social worker
KW - rural settings
KW - community psychiatric services
KW - personal problems
KW - 1953
KW - Community Services
KW - Professional Consultation
KW - Psychodynamic Psychotherapy
KW - Rural Environments
KW - Social Workers
KW - 1953
DO - 10.1111/j.1939-0025.1953.tb00105.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-38637-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY -
AU - Ullmann, Charles A.1
T1 - The Socially Maladjusted.
JO - Review of Educational Research
JF - Review of Educational Research
J1 - Review of Educational Research
PY - 1953/12//
Y1 - 1953/12//
VL - 23
IS - 5
CP - 5
M3 - Article
SP - 432
EP - 452
SN - 00346543
AB - The article presents a review of several studies on socially maladjusted children. The term socially maladjusted is used in the study to refer both disorders in which emotional or personal aspects are prominent and disorders which involve interactive relationships. A study conducted by Murphy, Shirley and Witmer have pointed out that court statistics are wholly inadequate as a measure of the amount of youthful illegal behavior in the community. A number of studies have been devised to analyze the process by which maladjustment is recognize. The may be reviewed from the standpoint of factors associated with the rater and aspects of social performance. Studies of the role of teachers in the identification of problem behavior have been relatively numerous, although frequently only exploratory and fact-finding in character. The influence of experience or proved competence as a teacher on whether a given behavior is regarded as problem behavior may be inferred from studies by Jones and Slobetz.
KW - Problem children
KW - Behavior disorders in children
KW - Problem children -- Education
KW - Problem youth
KW - Emotional problems of children
KW - Social problems
KW - Behavior
KW - Children -- Attitudes
KW - Psychology
N1 - Accession Number: 19158783; Authors: Ullmann, Charles A. 1; Affiliations: 1: National Institute of Mental Health, United States Public Health Service, Bethesda, Maryland; Subject: Problem children; Subject: Behavior disorders in children; Subject: Problem children -- Education; Subject: Problem youth; Subject: Emotional problems of children; Subject: Social problems; Subject: Behavior; Subject: Children -- Attitudes; Subject: Psychology; Number of Pages: 21p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Hirsch, Herbert M.
T1 - Environmental Factors Influencing the Differentiation of Protoperithecia and their Relation to Tyrosinase and Melanin Formation in Neurospora crassa.
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1954/01//
VL - 7
IS - 1
M3 - Article
SP - 72
EP - 97
PB - Wiley-Blackwell
SN - 00319317
AB - The relation of environment to the differentiation of protoperithecia and two closely allied phenomena, tyrosinase and melanin formation, has been studied in Neurospora crassa. A temperature of 25° C is optimal as regards the formation of protoperithecia while a temperature of 35° inhibits both the formation of protoperithecia and fruitbodies. Increasing amounts of nitrogen, both organic and inorganic, depress and eventually suppress protoperithecia formation specifically; protoperithecia formed at intermediate concentrations of nitrogen appear unpigmented and are largely or wholly nonfunctional, the latter depending in a secondary way on the carbon/nitrogen ratio of the medium on which growth has taken place. The pigment present in the protoperithecia has been found to be melanic in nature: it is produced to a considerable extent only under conditions permitting the formation of functional protoperithecia. Mycelia grown under conditions permitting optimal protoperithecia formation show strong tyrosinase activity which makes its appearance concomitant with or slightly precedes protoperithecial formation; the greatest increase in rate of protoperithecia production coincides with maximal tyrosinase activity of the mycelium. Tyrosinase and melanin are low or absent in mycelia growth at 35°. Mycelia in which protoperithecia formation bas been completely suppressed through the addition of organic nitrogen show very little tyrosinase activity after 7 days' growth and tyrosine is oxidized only to a red pigment; after 14 days a strong tyrosinase can be demonstrated which rapidly oxidizes tyrosine to melanin, but during actual growth only a very small amount of melanin deposition takes place. This inhibition is not due lo the presence of sulfur-containing substances. The possible significance of these findings is discussed. By appropriate changes in the relative and absolute amounts of carbon and nitrogen different stages in the sexual cycle of the organism can be affected, but any condition which prevents the exhaustion of nitrate (and possibly nitrogen in general) always affects in a deleterious manner both the number and normal functioning of the protoperithecia formed. The processes of fertilization and fruit formation, on the other hand, are not greatly affected by the presence of nitrate. Use of tyrosinase inhibitors suppresses the formation of protoperithecia and melanin more or less completely; some other enzyme inhibitors used do not show the same effect and apparently have another site of action. The question of whether tyrosine metabolism has a causal relation to the differentiation and normal functioning of protoperithecia, or whether tyrosinase and melanin are invariable, though accidental, concomitants of protoperithecial formation is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitrogen
KW - Enzyme inhibitors
KW - Cell differentiation
KW - Melanins
KW - Melanocytes
KW - Amino acids
KW - Neurospora crassa
N1 - Accession Number: 15770136; Hirsch, Herbert M. 1; Affiliations: 1: U.S. Public Health Service Research Fellow of the National Institutes of Health, Institute of Genetics, University of Copenhagen.; Issue Info: 1954, Vol. 7 Issue 1, p72; Thesaurus Term: Nitrogen; Thesaurus Term: Enzyme inhibitors; Subject Term: Cell differentiation; Subject Term: Melanins; Subject Term: Melanocytes; Subject Term: Amino acids; Subject Term: Neurospora crassa; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 26p; Document Type: Article
L3 - 10.1111/1399-3054.ep15770136
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15770136&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1956-02649-001
AN - 1956-02649-001
AU - Hochbaum, Godfrey M.
T1 - The relation between group members' self-confidence and their reactions to group pressures to uniformity.
JF - American Sociological Review
JO - American Sociological Review
JA - Am Sociol Rev
Y1 - 1954///
VL - 19
SP - 678
EP - 687
CY - US
PB - American Sociological Assn
SN - 0003-1224
SN - 1939-8271
N1 - Accession Number: 1956-02649-001. Partial author list: First Author & Affiliation: Hochbaum, Godfrey M.; U. S. Public Health Service, Washington, D. C. Other Publishers: Sage Publications. Release Date: 19560201. Correction Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 10. Issue Publication Date: 1954.
KW - SELF
KW - CONFIDENCE
KW - & GROUP PRESSURES
KW - GROUP
KW - PRESSURE
KW - & SELF-CONFIDENCE
KW - SOCIAL PSYCHOLOGY
KW - 1954
KW - No terms assigned
KW - 1954
DO - 10.2307/2087914
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1955-06326-001
AN - 1955-06326-001
AU - Newman, Sidney H.
T1 - Quantitative analysis of verbal evaluations.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1954/10//
VL - 38
IS - 5
SP - 293
EP - 296
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 1955-06326-001. Partial author list: First Author & Affiliation: Newman, Sidney H.; U. S. Public Health Service, Washington, D. C. Release Date: 19550401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evaluation. Minor Descriptor: Quantitative Methods; Racial and Ethnic Differences; Verbal Tests. Classification: Research Methods & Experimental Design (2260). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: Oct, 1954. Copyright Statement: American Psychological Association. 1954.
AB - A procedure for quantitatively analyzing verbal material (comments in officer efficiency reports) for the comparison of officer performance is described. The material is quantified by categorizing each comment and assigning to it the score for comparable comments in the empirically derived Thurstone-type master scoring scale for that category. 'The findings show that: (a) the comments can be reliably placed on a nine-point scale by a relatively small number of judges; and (b) scores, based on either the individual comments in each category or the average comment scores for each report, are reliable. It is suggested that the procedures… can be utilized for other types of verbal material.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quantitative analysis
KW - verbal evaluations
KW - scoring scale
KW - officer performance
KW - 1954
KW - Evaluation
KW - Quantitative Methods
KW - Racial and Ethnic Differences
KW - Verbal Tests
KW - 1954
DO - 10.1037/h0061058
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1955-06326-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1955-08622-001
AN - 1955-08622-001
AU - Lamson, Warren C.
T1 - Fee charging in mental health clinics.
JF - Journal of Psychiatric Social Work
JO - Journal of Psychiatric Social Work
Y1 - 1955///
VL - 24
SP - 105
EP - 107
N1 - Accession Number: 1955-08622-001. PMID: 13222368 Partial author list: First Author & Affiliation: Lamson, Warren C.; Public Health Service, Bethesda, Md. Release Date: 19550601. Correction Date: 20161128. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 3. Issue Publication Date: 1955.
AB - The author reviews the present status of fee charging by various social services, the present philosophy in relation to fee charging, practical problems of setting fees, and the importance of interpretation to the community whenever fee charging becomes a clinic procedure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - FEE
KW - IN MENTAL HEALTH CLINIC
KW - MENTAL HYGIENE
KW - CLINIC
KW - FEE CHARGING IN
KW - MENTAL
KW - HEALTH
KW - FEES IN
KW - METHODOLOGY
KW - TECHNIQUES
KW - 1955
KW - No terms assigned
KW - 1955
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1956-06615-001
AN - 1956-06615-001
AU - Ey, John A. Jr.
T1 - Techniques and psychology of instructing.
JF - American Journal of Occupational Therapy
JO - American Journal of Occupational Therapy
JA - Am J Occup Ther
Y1 - 1955///
VL - 9
SP - 248
EP - 250
CY - US
PB - American Occupational Therapy Assn
SN - 0272-9490
SN - 1943-7676
N1 - Accession Number: 1956-06615-001. PMID: 13258722 Partial author list: First Author & Affiliation: Ey, John A. Jr.; Office of the Surgeon General, Department of the Army, Washington, D. C. Release Date: 19560501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Professional Psychological & Health Personnel Issues (3400). Page Count: 3. Issue Publication Date: 1955.
AB - Methods of teaching are briefly reviewed with emphasis especially concentrated upon the ways in which instructional material can be made optimally effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - TEACHING
KW - METHOD
KW - REVIEW
KW - PROFESSIONAL PROBLEMS OF PSYCHOLOGY
KW - 1955
KW - No terms assigned
KW - 1955
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1956-00983-001
AN - 1956-00983-001
AU - Hollister, William Gray
AU - Husband, Grant W.
T1 - Two role-playing methods of using mental-health films and plays.
JF - Mental Hygiene. New York
JO - Mental Hygiene. New York
Y1 - 1955///
VL - 39
SP - 277
EP - 283
N1 - Accession Number: 1956-00983-001. PMID: 14369708 Partial author list: First Author & Affiliation: Hollister, William Gray; U. S. Public Health Service, Region IV, Atlanta, Ga. Release Date: 19560101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 7. Issue Publication Date: 1955.
AB - Two methods of audience participation in role-playing are described. The 'feeling with' method is based upon the assignment of audience subgroups the task of empathizing with specific assigned principal characters in the play or film, followed by a 'buzz session' and interviewing. A second method, the 'helping group' technique, is based upon the selection of a particular sequence in a film or play, telling the audience about it, and when the end of that sequence is reached in the performance, cutting off the balance of the production and requiring the audience to supply the content of the role of the depicted helpful individual. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ROLE
KW - PLAYING
KW - & MENTAL HEALTH FILMS
KW - MENTAL HEALTH
KW - FILMS
KW - AUDIENCE ROLE PLAYING
KW - CLINICAL PSYCHOLOGY
KW - GUIDANCE
KW - COUNSELING
KW - 1955
KW - No terms assigned
KW - 1955
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gentile, Arthur C.
AU - Klein, Richard M.
T1 - The Apparent Necessity of Indoleacetic Acid for the Growth of Diplodia (Fungi Imperfecti).
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1955/04//
VL - 8
IS - 2
M3 - Article
SP - 291
EP - 299
PB - Wiley-Blackwell
SN - 00319317
AB - Focuses on the results of growth studies on a strain of Diplodia in the presence of 2,4,6 trichlorophenoxyacetic acid (TCPA) or indoleacetic acid (IAA) and combination of these two compounds. Necessity of IAA for the growth of Diploida; Effect of IAA and TCPA on the growth of Diploidia; Implications of the findings of these studies.
KW - Diplodia
KW - Plant hormones
KW - Acetic acid
KW - Sphaeropsidaceae
KW - Plant physiology
KW - Indoleacetic acid
KW - Plant growth promoting substances
N1 - Accession Number: 15996297; Gentile, Arthur C. 1,2,3; Klein, Richard M. 1,2; Affiliations: 1: Department of Botany, Duke University, Durham, North Carolina; 2: The New Botanical Garden, New York, N. Y.; 3: Public Health Service Research Fellow, National Cancer Institute; Issue Info: 1955, Vol. 8 Issue 2, p291; Thesaurus Term: Diplodia; Thesaurus Term: Plant hormones; Thesaurus Term: Acetic acid; Thesaurus Term: Sphaeropsidaceae; Thesaurus Term: Plant physiology; Subject Term: Indoleacetic acid; Subject Term: Plant growth promoting substances; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gentile, Arthur C.
AU - Naylor, Aubrey W.
T1 - The Metabolism of Rumex Virus Tumors. Terminal Respiratory enzymes.
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1955/07//
VL - 8
IS - 3
M3 - Article
SP - 682
EP - 690
PB - Wiley-Blackwell
SN - 00319317
AB - A survey was made of the terminal respiratory enzymes in Rumex virus tumor tissue grown in culture. The oxygen uptake of slices of Rumex virus tumors was inhibited about 45 per cent by 0.001 M cyanide. This inhibition suggested the presence of a heavy-metal mediated oxidase system. Cytochrome oxidase. DPNH-linked cytochrome c reductase, and succinic dehydrogenase were found to be present. Catalase and peroxidase activities were also demonstrated. The copper-protein oxidases - polyphenol oxidase, laccase, and ascorbic acid oxidase, were absent in this tissue. Although a residual cyanide respiration suggested the presence of a flavin oxidase, attempts to show glycolic acid dehydrogcnase activity were unsuccessful. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physiologia Plantarum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Plant metabolism
KW - Plant physiology
KW - Metabolism
KW - Cytochromes
KW - Metalloenzymes
KW - Dehydrogenases
N1 - Accession Number: 15794144; Gentile, Arthur C. 1; Naylor, Aubrey W. 2; Affiliations: 1: Public Health Service Research Fellow of the National Cancer Institute.; 2: Department of Botany, Duke University, Durham, North Carolina.; Issue Info: 1955, Vol. 8 Issue 3, p682; Thesaurus Term: Plant metabolism; Thesaurus Term: Plant physiology; Subject Term: Metabolism; Subject Term: Cytochromes; Subject Term: Metalloenzymes; Subject Term: Dehydrogenases; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1399-3054.ep15794144
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15794144&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Krog, John
T1 - Notes on Temperature Measurements Indicative of Special Organization in Artic and Subarctic Plants for Utilization of Radiated Heat from the Sun.
JO - Physiologia Plantarum
JF - Physiologia Plantarum
Y1 - 1955/10//
VL - 8
IS - 4
M3 - Article
SP - 836
EP - 839
PB - Wiley-Blackwell
SN - 00319317
AB - This article presents notes on temperature measurements indicative of special organization in arctic and subarctic plants for utilization of radiated heat from the sun. The possible existence of special organizational features of plants and animals in arctic and subarctic regions facilitating the utilization of solar energy for warming purposes seems to have been disregarded. It had been anticipated that the darkened catkin would warm above the natural one with its shiny hair. The measurements show, however, that this was not the case. This leads to the hypothesis that the shiny hair on the pussywillow in one way or another facilitates heating by the sun rays. Before discussing the physical explanation of this hypothesis the structure of the pussywillow might be worth recapitulating.
KW - Plants
KW - Solar energy
KW - Solar radiation
KW - Physical measurements
KW - Hypothesis
KW - Pussy willows
N1 - Accession Number: 17318598; Krog, John 1; Affiliations: 1: Arctic Health Research Center, U. S. Public Health Service, Anchorage, Alaska.; Issue Info: 1955, Vol. 8 Issue 4, p836; Thesaurus Term: Plants; Thesaurus Term: Solar energy; Subject Term: Solar radiation; Subject Term: Physical measurements; Subject Term: Hypothesis; Subject Term: Pussy willows; NAICS/Industry Codes: 221114 Solar Electric Power Generation; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1399-3054.ep17318598
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17318598&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cohen, Sumner S.
T1 - Chemotherapy for pulmonary tuberculosis in older adults.
JO - Geriatrics
JF - Geriatrics
Y1 - 1956/03//
VL - 11
IS - 3
M3 - Article
SP - 103
EP - 106
SN - 0016867X
N1 - Accession Number: 17226573; Cohen, Sumner S. 1,2,3; Source Information: Mar1956, Vol. 11 Issue 3, p103; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article; Full Text Word Count: 1978
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Adams, Scott
T1 - INFORMATION - A NATIONAL RESOURCE.
JO - American Documentation
JF - American Documentation
Y1 - 1956/04//
VL - 7
IS - 2
M3 - Article
SP - 71
EP - 75
SN - 0096946X
AB - Focuses on information resources. Observation on information resources; Definitions of scientific information; Views of documentalists on information resources; Association of information resources with natural resources; Suggestions for organized documentation.
KW - INFORMATION resources
KW - INFORMATION science
KW - DOCUMENTATION
KW - NATURAL resources
N1 - Accession Number: 16810762; Adams, Scott 1; Affiliations: 1: Librarian, National Institutes of Health, Public Health Service, U. S. Dept. of Health, Education, and Welfare; Issue Info: Apr1956, Vol. 7 Issue 2, p71; Thesaurus Term: INFORMATION resources; Thesaurus Term: INFORMATION science; Thesaurus Term: DOCUMENTATION; Subject Term: NATURAL resources; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Statti, Louis W.
T1 - Ophthalmic problems in diabetes.
JO - Geriatrics
JF - Geriatrics
Y1 - 1956/06//
VL - 11
IS - 6
M3 - Article
SP - 263
EP - 265
SN - 0016867X
N1 - Accession Number: 17208339; Statti, Louis W. 1,2; Source Information: Jun1956, Vol. 11 Issue 6, p263; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1253
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DP - EBSCOhost
DB - hch
ER -
TY - Gen
ID - 9999-13910-000
AN - 9999-13910-000
AU - Newman, Sidney H.
AU - Howell, Margaret A.
AU - Harris, Frank J.
T1 - Experimental Efficiency Report
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1957///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-13910-000. Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service, United States. Release Date: 20120813. Correction Date: 20151109. Test Format: Items in Section I use tetrads; raters mark the one that is most descriptive and least descriptive of the ratee. Items in Sections II and III use 10-point rating scales. Items in Section IV are marked as applying or not applying to the ratee.. Language: English. Constructs: Job Performance Efficiency; Classification: Organizational, Occupational, and Career Development (7000). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of this report is to examine methods for evaluating efficiency in professional health personnel.
AB - Description: In a study comparing the forced choice technique with other methods for evaluating the performance of commissioned professional health personnel in the United States Public Health Service, an Experimental Efficiency Report (Newman, Howell, & Harris, 1957) was developed. The Report, incorporating forced choice items and other evaluation materials not in use in the Service in 1949, was designed and distributed to the supervisors of active-duty officers. The Report included 4 sections. Section I--Forced Choice--consisted of 50 tetrads adapted from items developed by the Department of the Army. Each tetrad was composed of four words or phrases descriptive of job performance or personal qualifications from which a supervisor was to select (a) the one most descriptive and (b) the one least descriptive of the individual he was rating. Section II--Job Proficiency--was a list of ten major work areas in the Public Health Service from which a supervisor was to indicate the ratee's primary job function. The supervisor then rated, on a ten-point scale, the quality of the ratee's performance in this function. Section III--Personal Qualifications--consisted of ten-point rating scales for the evaluation of eight personality characteristics such as reaction to criticism, freedom from bias and emotional upset, ability to work with others, ability to act on own responsibility, and diligence and persistence in performing necessary work. Section IV--Check List--consisted of 22 statements which were to be marked as applying or not applying to the ratee. The statements concerned topics such as professional knowledge and interest in work. The results obtained for the forced choice tetrads generally produced higher validity coefficients than other methods of assessing or reporting efficiency. Since rating-scale methods of efficiency reporting have widespread usage, it may also be of general interest that these methods produced satisfactory validity as measures of professional performance. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Experimental Efficiency Report
KW - Health Personnel Competency
KW - Test Development
U5 - Experimental Efficiency Report [Test Development]Forced choice and other methods for evaluating professional health personnel. (AN: 2011-17175-001 from PsycINFO) Newman, Sidney H.; Howell, Margaret A.; Harris, Frank J.; 1957. Source: Psychological Monographs: General and Applied. 71(10), American Psychological Association, US; 1957; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Health Personnel Keywords: Experimental Efficiency Report; Health Personnel Competency; Test Development; Subjects: Health Personnel; Measurement; Professional Competence; Test Construction;
DO - 10.1037/t13910-000
L3 - Sample; Full text; 999913910_sample_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-13910-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 2011-17175-001
AN - 2011-17175-001
AU - Newman, Sidney H.
AU - Howell, Margaret A.
AU - Harris, Frank J.
T1 - Forced choice and other methods for evaluating professional health personnel.
JF - Psychological Monographs: General and Applied
JO - Psychological Monographs: General and Applied
JA - Psychol Monogr
Y1 - 1957///
VL - 71
IS - 10
SP - 1
EP - 27
CY - US
PB - American Psychological Association
SN - 0096-9753
N1 - Accession Number: 2011-17175-001. Other Journal Title: Psychological Monographs; The Psychological Monographs; The Psychological Review: Monograph Supplements. Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Choice Behavior; Job Performance; Public Health Services; Health Personnel. Minor Descriptor: Public Health. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Job Proficiency Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 27. Issue Publication Date: 1957. Publication History: Accepted Date: Feb 17, 1957.
AB - This study was undertaken to compare the forced choice technique with other methods for evaluating the performance of commissioned professional health personnel in the United States Public Health Service. The criteria of performance within the Public Health Service consisted of 20-point graphic rating scales used for the evaluation of each of the following factors: Work Performance, Administrative Ability, Personality (Personal Qualifications), and Over-all Value to the Service. Instructions for each scale requested raters to compare the ratee with a typical group of personnel having similar duties and responsibilities. Criterion ratings were obtained during 1949 from 45 of the 54 Public Health Service installations in the United States, including 14 hospitals, 10 regional offices, 8 divisions, 8 laboratories of the National Institutes of Health, and 5 other installations such as outpatient clinics. This study has compared the relative efficacy of the forced choice technique with other more conventional evaluation methods as measures of the performance of professional health personnel working as commissioned officers in the United States Public Health Service. The criteria of Service performance were twenty-point graphic rating scales for the evaluation of Work Performance and Personality. The Forced Choice section of the Experimental Report was highly effective for evaluating the performance of professional personnel commissioned in the Public Health Service. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - forced choice
KW - professional health personnel
KW - Public Health Services
KW - performance
KW - 1957
KW - Choice Behavior
KW - Job Performance
KW - Public Health Services
KW - Health Personnel
KW - Public Health
KW - 1957
DO - 10.1037/h0093710
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-17175-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1959-01643-001
AN - 1959-01643-001
AU - Kramer, Morton
AU - Person, Philip H. Jr.
AU - Tarjan, George
AU - Morgan, Richard
AU - Wright, Stanley W.
T1 - A method for determination of probabilities of stay, release, and death, for patients admitted to a hospital for the mentally deficient: The experience of Pacific State Hospital during the period 1948-1952.
JF - American Journal of Mental Deficiency
JO - American Journal of Mental Deficiency
JA - Am J Ment Defic
Y1 - 1957///
VL - 62
SP - 481
EP - 495
CY - US
PB - American Assn on Mental Retardation
SN - 0002-9351
N1 - Accession Number: 1959-01643-001. PMID: 13469851 Other Journal Title: American Journal on Intellectual and Developmental Disabilities; American Journal on Mental Retardation. Partial author list: First Author & Affiliation: Kramer, Morton; National Institute of Mental Health, Public Health Service, Bethesda, Md. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19590101. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 15. Issue Publication Date: 1957.
AB - A series of analyses is presented demonstrating 'a method for determining the probability of release, death and retention for patients admitted to a hospital for the mentally retarded.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MENTAL RETARDATION
KW - HOSPITAL STAY
KW - ANALYSIS
KW - HOSPITAL
KW - FOR MENTAL DEFECTIVES
KW - RETENTION PROBABILITY
KW - MENTAL DEFICIENCY
KW - 1957
KW - No terms assigned
KW - 1957
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-01643-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Greenblatt, Robert B.
T1 - Treatment of menopausal symptoms.
JO - Geriatrics
JF - Geriatrics
Y1 - 1957/07//
VL - 12
IS - 7
M3 - Article
SP - 452
EP - 453
SN - 0016867X
N1 - Accession Number: 17797140; Greenblatt, Robert B. 1,2; Source Information: Jul1957, Vol. 12 Issue 7, p452; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 786
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Syme, S. Leonard
T1 - Sociology: With Application to Nursing and Health Education (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1957/12//
VL - 22
IS - 6
M3 - Book Review
SP - 774
EP - 775
SN - 00031224
AB - Reviews the book "Sociology: With Application to Nursing and Health Education," by Francis J. Brown.
KW - SOCIAL medicine
KW - NONFICTION
KW - BROWN, Francis J.
KW - SOCIOLOGY (Book)
N1 - Accession Number: 12782072; Syme, S. Leonard 1; Affiliations: 1: U. S. Public Health Service; Issue Info: Dec57, Vol. 22 Issue 6, p774; Subject Term: SOCIAL medicine; Subject Term: NONFICTION; Reviews & Products: SOCIOLOGY (Book); People: BROWN, Francis J.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Terrill Jr., James G.
T1 - Some Public Health Aspects of Radioactive Wastes.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1958/01//
VL - 14
IS - 1
M3 - Article
SP - 44
EP - 45
SN - 00963402
AB - The article discusses public health aspects of radioactive wastes in the U.S. With the plausible growth in the industrial use of nuclear energy, it will be necessary from a public health standpoint, to consider possible exposures from substantial quantities of radioactive wastes in addition to exposure from all sources of radiation, both natural and man-made. In this paper, the author discusses the several sources of radioactive wastes in a qualitative fashion and reviews quantitatively the sources that may lead to significant exposures at some future date.
KW - RADIOACTIVE wastes
KW - PUBLIC health
KW - WASTE management
KW - NUCLEAR industry
KW - INDUSTRIAL workers
KW - RADIATION exposure
KW - RADIOACTIVE pollution
KW - RADIOACTIVITY -- Safety measures
KW - RADIOACTIVE substances -- Safety regulations
KW - UNITED States
KW - Peaceful uses of atomic energy
KW - THE MILITARY SITUATION
N1 - Accession Number: 21385885; Terrill Jr., James G. 1; Affiliations: 1 : Chief, Radiological Health Program, Bureau of State Services, Public Health Service; Source Info: Jan1958, Vol. 14 Issue 1, p44; Subject Term: RADIOACTIVE wastes; Subject Term: PUBLIC health; Subject Term: WASTE management; Subject Term: NUCLEAR industry; Subject Term: INDUSTRIAL workers; Subject Term: RADIATION exposure; Subject Term: RADIOACTIVE pollution; Subject Term: RADIOACTIVITY -- Safety measures; Subject Term: RADIOACTIVE substances -- Safety regulations; Subject: UNITED States; Author-Supplied Keyword: Peaceful uses of atomic energy; Author-Supplied Keyword: THE MILITARY SITUATION; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - CHAP
ID - 2006-10211-003
AN - 2006-10211-003
AU - Evarts, Edward V.
ED - Rinkel, Max
ED - Rinkel, Max, (Ed)
T1 - Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept.
T2 - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957.
Y1 - 1958///
SP - 41
EP - 62
CY - New York, NY, US
PB - McDowell, Obolensky
N1 - Accession Number: 2006-10211-003. Partial author list: First Author & Affiliation: Evarts, Edward V.; National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Behavior; Electrophysiology; Lysergic Acid Diethylamide; Neurology; Pharmacology. Minor Descriptor: Biochemistry; Bufotenine; Cats; Experimental Psychosis; Experimentation; Monkeys; Psychiatry; Psychosis; Serotonin. Classification: Psychopharmacology (2580); Schizophrenia & Psychotic States (3213). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - Within recent years three discoveries have led to increased prominence of psychotomimetic agents as research tools in experimental psychiatry. These three discoveries were: first, the demonstration of the remarkable psychological actions and potency of d-lysergic acid diethylamide (LSD); second, the isolation and chemical identification of 5-hydroxytryptamine (5-HT) (10, 30); and third, the demonstration that LSD is a potent antagonist of 5-HT in vitro (19, 41). In this chapter neuropharmacological studies in animals on the basis of these three fundamental discoveries are summarized, and as the result of these studies speculations about a chemical basis for psychosis in humans are offered. The experiments were begun in an attempt to gain further knowledge about those behavioral and electrophysiological effects of LSD which might be relevant to an explanation of the effects of LSD on psychological processes in man. The hypothesis of Gaddum (20) and of Woolley and Shaw (41, 42) that the actions of LSD were related to its interaction with 5-HT served as a point of departure. One approach to obtaining further knowledge of the mechanism of action of LSD was to examine the effects of other substances whose actions might also be related to an interaction with 5-HT. One such obvious source is the class of structural congeners of 5-HT, and therefore a series of experiments was started with a small group of tryptamine and LSD derivatives. It was the purpose of these experiments to obtain information concerning the degree to which analogues of 5-HT might produce neuropharmacological effects which corresponded to those of the LSD. The first 5-HT congener which we studied was bufotenine, the N-dimethyl derivative of 5-HT. The investigations of the actions of bufotenine were undertaken on the basis of the theoretical considerations and as the result of Stromberg's (37) discovery that bufotenine is the principal alkaloid of cohoba (33), which the natives of Haiti used as a stimulating snuff. The possibility that bufotenine was the active agent in cohoba, and, therefore, a psychotomimetic agent, made the studies of its neuropharmacological actions of particular interest. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chemical basis for psychosis
KW - monkeys
KW - neuropharmacological studies
KW - cats
KW - LSD
KW - 5-HT
KW - experimental psychiatry
KW - behavior
KW - bufotenine
KW - electrophysiology
KW - 1958
KW - Behavior
KW - Electrophysiology
KW - Lysergic Acid Diethylamide
KW - Neurology
KW - Pharmacology
KW - Biochemistry
KW - Bufotenine
KW - Cats
KW - Experimental Psychosis
KW - Experimentation
KW - Monkeys
KW - Psychiatry
KW - Psychosis
KW - Serotonin
KW - 1958
DO - 10.1037/11190-003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-10211-015
AN - 2006-10211-015
AU - Brodie, Bernard B.
AU - Bogdanski, Donald F.
AU - Shore, Parkhurst A.
ED - Rinkel, Max
ED - Rinkel, Max, (Ed)
T1 - Serotonin in Relation to Brain Function: III. The Action of Psychotropic Drugs (A Biochemical and Physiological Interpretation).
T2 - Chemical concepts of psychosis: Proceedings of the Symposium on Chemical Concepts of Psychosis held at the Second International Congress of Psychiatry in Zurich, Switzerland, September 1 to 7, 1957.
Y1 - 1958///
SP - 190
EP - 203
CY - New York, NY, US
PB - McDowell, Obolensky
N1 - Accession Number: 2006-10211-015. Partial author list: First Author & Affiliation: Brodie, Bernard B.; Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Symposium on Chemical Concepts of Psychosis, Sep, 1957, Zurich, Switzerland. Conference Note: The symposium was held at the Second International Congress of Psychiatry. Major Descriptor: Brain; Drugs; Parasympathetic Nervous System; Pharmacology; Sympathetic Nervous System. Minor Descriptor: Biochemistry; Norepinephrine; Physiology; Serotonin; Theories. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 14.
AB - The theory is presented that the autonomic, somatic and psychic functions of the body are maintained in a balanced state by two opposing systems, the trophotropic and ergotropic, and that these systems have receptor sites that are modulated by serotonin and norepinephrine, respectively. A number of drugs may be classified and their mechanism of action described according to their effects on the trophotropic or ergotropic systems. In considering the following views, it must be borne in mind that since the two subcortical brain systems are antagonistic, it should be possible to produce the same syndrome by stimulating one system or by depressing the other. Accordingly, the following possibilities present themselves: A) A drug may produce the trophotropic syndrome by activation of the trophotropic system or by depression of the ergotropic system. B) A drug may produce the ergotropic syndrome by blocking the trophotropic system (thus unmasking the ergotropic) or by directly stimulating the ergotropic system. C) A drug may affect the diencephalic integrative mechanisms by blocking monoamine oxidase. D) A drug may block the synthesis of serotonin or norepinephrine. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - subcortical brain systems
KW - serotonin
KW - psychic functions
KW - ergotropic system
KW - theory
KW - autonomic functions
KW - psychotrophic drug action
KW - trophotropic system
KW - norepinephrine
KW - somatic functions
KW - 1958
KW - Brain
KW - Drugs
KW - Parasympathetic Nervous System
KW - Pharmacology
KW - Sympathetic Nervous System
KW - Biochemistry
KW - Norepinephrine
KW - Physiology
KW - Serotonin
KW - Theories
KW - 1958
DO - 10.1037/11190-015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10211-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1959-06531-001
AN - 1959-06531-001
AU - Dekaban, A. S.
T1 - Mental deficiency: Recessive transmission to all children by parents similarly affected.
JF - A.M.A. Archives of Neurology and Psychiatry
JO - A.M.A. Archives of Neurology and Psychiatry
JA - AMA Arch Neurol Psychiatry
Y1 - 1958///
VL - 79
SP - 123
EP - 131
CY - US
PB - American Medical Association
SN - 0096-6886
N1 - Accession Number: 1959-06531-001. PMID: 13497352 Other Journal Title: Archives of Neurology & Psychiatry. Partial author list: First Author & Affiliation: Dekaban, A. S.; United States Public Health Service, Bethesda, Md. Release Date: 19590301. Correction Date: 20120312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 9. Issue Publication Date: 1958.
AB - Case report is presented of the parents and 3 children all of whom were found to be mental defectives of an undifferentiated type. Comprehensive examinations revealed no evidence of so called congenital anomalies. 'Analysis of the pedigree is compatible with autosomal recessive inheritance of an abnormal trait in a homozygous combination.' The accumulation of pedigrees is considered a fruitful method in the investigation of undifferentiated mental deficiency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MENTAL RETARDATION
KW - RECESSIVE TRANSMISSION
KW - HEREDITY
KW - & INTELLIGENCE
KW - MENTAL
KW - DEFICIENCY
KW - MENTAL DEFICIENCY
KW - 1958
KW - No terms assigned
KW - 1958
DO - 10.1001/archneurpsyc.1958.02340020003001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1959-06531-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1960-01131-001
AN - 1960-01131-001
AU - Birren, James E.
T1 - Aging and psychological adjustment.
JF - Review of Educational Research
JO - Review of Educational Research
JA - Rev Educ Res
Y1 - 1958///
VL - 28
SP - 475
EP - 490
CY - US
PB - American Educational Research Assn
SN - 0034-6543
SN - 1935-1046
N1 - Accession Number: 1960-01131-001. Partial author list: First Author & Affiliation: Birren, James E.; U. S. Public Health Service, Bethesda, Md. Other Publishers: Sage Publications. Release Date: 19600101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 16. Issue Publication Date: 1958.
AB - Scientific and professional interest in older persons increased markedly during the last 3 years, but research increased only slowly, and the literature on aging, in comparison with research on child development, is small. There is a deficit of research on the majority of the older population who are living in their own households. The lack of pertinent research in many aspects of normal aging reflects a conceptual limitation of most behavior theories, such as learning, perception, and personality, which have never considered age as a variable. 161-item bibliog. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - OLD AGE
KW - ADJUSTMENT IN
KW - MATURITY & OLD AGE
KW - 1958
KW - No terms assigned
KW - 1958
DO - 10.2307/1168974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-01131-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Pomrinse, S. David
T1 - Marginal man: a concept of the aging process.
JO - Geriatrics
JF - Geriatrics
Y1 - 1958/11//
VL - 13
IS - 11
M3 - Editorial
SP - 765
EP - 768
SN - 0016867X
N1 - Accession Number: 17810314; Pomrinse, S. David 1; Source Information: Nov1958, Vol. 13 Issue 11, p765; Number of Pages: 4p; Document Type: Editorial; Full Text Word Count: 1657
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17810314&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hunt, G. Halsey
T1 - Implications of aging as predicted by population changes.
JO - Geriatrics
JF - Geriatrics
Y1 - 1959/01//
VL - 14
IS - 1
M3 - Article
SP - 1
EP - 7
SN - 0016867X
N1 - Accession Number: 20877890; Hunt, G. Halsey 1,2; Source Information: Jan1959, Vol. 14 Issue 1, p1; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 3943
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DP - EBSCOhost
DB - hch
ER -
TY - CHAP
ID - 2006-20945-012
AN - 2006-20945-012
AU - Wikler, Abraham
ED - Cole, Jonathan O.
ED - Gerard, Ralph W.
ED - Cole, Jonathan O., (Ed)
ED - Gerard, Ralph W., (Ed)
T1 - The Loci and Mechanisms of Action of Phrenotropic Drugs Considered in Relation to Screening Procedures.
T2 - Psychopharmacology: Problems in evaluation.
Y1 - 1959///
SP - 213
EP - 223
CY - Washington, DC, US
PB - National Academy of Sciences
N1 - Accession Number: 2006-20945-012. Partial author list: First Author & Affiliation: Wikler, Abraham; Neuropsychiatric Section, Addiction Research Center, U. S. Public Health Service Hospital, Lexington, KY, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Behavior Disorders; Drug Therapy; Drugs; Neurophysiology; Screening. Minor Descriptor: Biochemistry. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11.
AB - Before we enter upon a discussion of particulars concerning the neurophysiological actions of drugs used in the treatment of behavioral disorders, I should like to consider the more general problems posed by the central topic of this conference, namely, the pre-clinical screening of phrenotropic agents. The term 'screening,' implies, of course, that we know the purpose for which our 'screens' are to be used; presumably, their dimensions and designs should be adequate to discriminate sedatives, stimulants, analgesics, euphoriants, tranquilizers, hallucinogens, and anti-hallucinogens from each other and from still other compounds with less desirable or irrelevant properties. It also implies that for each of these effects, there is a set of corresponding 'loci and mechanisms,' which can be isolated in the laboratory and woven into the appropriate 'screen' by the logic of current theories of behavior. These implications of the term 'screening' would seem to constitute a fair statement of the general problems which confront us, and it may be of value to summarize here, in very brief fashion, some impressions I have gained concerning them, from a rather extensive review of the pertinent literature, which has recently been published. The problem of screening cannot be separated from the problems of clinical testing, general biochemistry, neurophysiology, psychology, and pharmacology. These problems may be summarized in this chapter. A discussion on this paper is provided at the end of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurophysiology
KW - drugs
KW - behavior disorders
KW - phrenotropic agents
KW - screening
KW - loci and mechanisms
KW - 1959
KW - Behavior Disorders
KW - Drug Therapy
KW - Drugs
KW - Neurophysiology
KW - Screening
KW - Biochemistry
KW - 1959
DO - 10.1037/11259-012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-20945-020
AN - 2006-20945-020
AU - Isbell, Harris
ED - Cole, Jonathan O.
ED - Gerard, Ralph W.
ED - Cole, Jonathan O., (Ed)
ED - Gerard, Ralph W., (Ed)
T1 - Preliminary Clinical Assessment of Drugs Used in Mental Illness.
T2 - Psychopharmacology: Problems in evaluation.
Y1 - 1959///
SP - 317
EP - 330
CY - Washington, DC, US
PB - National Academy of Sciences
N1 - Accession Number: 2006-20945-020. Partial author list: First Author & Affiliation: Isbell, Harris; Addiction Research Center, U. S. Public Health Service, Lexington, KY, US. Release Date: 20061120. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book. Language: English. Conference Information: Conference on The Evaluation of Pharmacotherapy in Mental Health, Sep, 1956, Washington, DC, US. Conference Note: Presented at the aforementioned conference sponsored by the National Institute of Mental Health, the National Academy of Sciences--National Research Council, and the American Psychiatric Association. Major Descriptor: Drug Therapy; Drugs; Evaluation; Mental Disorders. Minor Descriptor: Drug Dosages; Toxicity. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14.
AB - These remarks are not intended to serve as a complete blueprint for testing new psychotherapeutic agents but only as a basis for discussion. Many things of importance have been omitted and some aspects of the problem, such as assessment of the effective dose range and toxic effects in acute trials, may have been overemphasized. Clinical assessment of new drugs requires investigative personnel, subjects or patients willing to participate in the experiments, and facilities for carrying out the work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotherapeutic agents
KW - dosage
KW - toxic effects
KW - drugs
KW - mental illness
KW - clinical assessment
KW - 1959
KW - Drug Therapy
KW - Drugs
KW - Evaluation
KW - Mental Disorders
KW - Drug Dosages
KW - Toxicity
KW - 1959
DO - 10.1037/11259-020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20945-020&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1960-06667-001
AN - 1960-06667-001
AU - Newman, Sidney H.
AU - Howell, Margaret A.
AU - Cliff, Norman
T1 - The analysis and prediction of a practical examination in dentistry.
JF - Educational and Psychological Measurement
JO - Educational and Psychological Measurement
JA - Educ Psychol Meas
Y1 - 1959///
VL - 19
SP - 557
EP - 568
CY - US
PB - Sage Publications
SN - 0013-1644
SN - 1552-3888
N1 - Accession Number: 1960-06667-001. Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service. Release Date: 19600401. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 12. Issue Publication Date: 1959.
AB - Using a practical examination in dentistry as the criterion, 4 aptitude tests, 4 written professional tests, an interview board, and a file evaluation board were used as predictor variables. The practical examination included Oral Diagnosis, Amalgam Restoration, and an Inlay Restoration rated by 2 dental officers using a specially-devised observation rating schedule. Ss were 100 dentists applying for appointment in the United States Public Health Service at the Assistant grade and 58 at the Senior Assistant grade. Validity r's of .64 and .86 were obtained for the 2 groups using the interview board assessments while the file evaluation method yielded r's of .59 and .66, respectively. The professional examinations had r's ranging from .26 to .61 while the r's for the aptitude tests varied from—.01 to .42 with 6 of the 8 r's not significant at the .05 level. Highly significant multiple R's of about .60 and .70 were obtained. A factorial analysis was also performed with 5 factors tentatively identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DENTISTRY
KW - PRACTICAL EXAMINATION IN
KW - PROFESSIONS
KW - 1959
KW - No terms assigned
KW - 1959
DO - 10.1177/001316445901900407
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-06667-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1960-04838-001
AN - 1960-04838-001
AU - Cliff, Norman
AU - Newman, Sidney H.
AU - Howell, Margaret A.
T1 - Selection of subprofessional hospital care personnel.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1959/02//
VL - 43
IS - 1
SP - 42
EP - 46
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 1960-04838-001. Partial author list: First Author & Affiliation: Cliff, Norman; United States Public Health Service, Washington, D.C. Release Date: 19600301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hospitals; Health Personnel. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Feb, 1959. Copyright Statement: American Psychological Association. 1959.
AB - 9 ability tests were administered to 150 nursing assistants in the United States Public Health Service. 18 12-point performance scales served as the criterion measure. Ratings were by 5 professional nurses. 'The validity of the predictors appears to be primarily due to a general ability rather than abilities specific to individual tests.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sub-professional hospital care personnel
KW - 1959
KW - Hospitals
KW - Health Personnel
KW - 1959
DO - 10.1037/h0044974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-04838-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hunt, G. Halsey
AU - Akers, Robert P.
AU - Mohler, Stanley R.
T1 - Research grant program of the National Institutes of Health: With special emphasis on research in aging.
JO - Geriatrics
JF - Geriatrics
Y1 - 1959/06//
VL - 14
IS - 6
M3 - Article
SP - 396
EP - 403
SN - 0016867X
N1 - Accession Number: 20877918; Hunt, G. Halsey 1,2; Akers, Robert P. 1,3; Mohler, Stanley R. 1,3; Source Information: Jun1959, Vol. 14 Issue 6, p396; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3556
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20877918&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1960-06228-001
AN - 1960-06228-001
AU - Brenner, Berthold
T1 - Estimating the prevelance of alcoholism: Toward a modification of the Jellinek formula.
JF - Quarterly Journal of Studies on Alcohol
JO - Quarterly Journal of Studies on Alcohol
JA - Q J Stud Alcohol
Y1 - 1959/06//
VL - 20
SP - 255
EP - 260
CY - US
PB - Alcohol Research Documentation
SN - 0033-5649
N1 - Accession Number: 1960-06228-001. PMID: 13668040 Other Journal Title: Journal of Studies on Alcohol; Journal of Studies on Alcohol and Drugs. Partial author list: First Author & Affiliation: Brenner, Berthold; United States Public Health Service, Washington, D.C. Release Date: 19600401. Correction Date: 20081124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: Jun, 1959.
AB - For logical and statistical reasons the formula (see 30: 1244) will overestimate prevalence of alcoholism in areas where deaths for cirrhosis of the liver are low and underestimate it where such death rate is high. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ALCOHOLISM
KW - JELLINEK FORMULA FOR ESTIMATING PREVALENCE OF
KW - BEHAVIOR PROBLEMS
KW - 1959
KW - No terms assigned
KW - 1959
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-06228-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1960-07512-001
AN - 1960-07512-001
AU - Russek, Henry I.
T1 - Emotional factors in atherosclerosis.
JF - Geriatrics
JO - Geriatrics
JA - Geriatrics
Y1 - 1959/08//
VL - 14
SP - 479
EP - 482
CY - US
PB - Advanstar Communications Inc.
SN - 0016-867X
N1 - Accession Number: 1960-07512-001. Other Journal Title: Patient Care. Partial author list: First Author & Affiliation: Russek, Henry I.; United States Public Health Service Hosp., Staten Island, N.Y. Release Date: 19600501. Correction Date: 20130617. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 4. Issue Publication Date: Aug, 1959.
AB - A comparison of 100 coronary patients under age 40 with 100 controls shows a 4.6 to 1 ratio of incidence of occupational and emotional stress in the coronary group. The disease may represent a maladaptation syndrome. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - STRESS
KW - ATHEROSCLEROSIS
KW - ARTERIOSCLEROSIS
KW - EMOTIONAL FACTORS IN
KW - MATURITY & OLD AGE
KW - 1959
KW - No terms assigned
KW - 1959
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-07512-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cooke, WM. Bridge
AU - Lawrence, Donald B.
T1 - SOIL MOULD FUNGI ISOLATED FROM RECENTLY GLACIATED SOILS IN SOUTH-EASTERN ALASKA.
JO - Journal of Ecology
JF - Journal of Ecology
Y1 - 1959/10//
VL - 47
IS - 3
M3 - Article
SP - 529
EP - 549
SN - 00220477
AB - The article reports on the soil fungi isolated from two soil samples obtained from glacier ice and glaciated surfaces in southeastern Alaska. In the isolation of soil fungi from the two soil samples, a soil plate dilution technique was used. Using the Waksman soil-mould plate-count agar method, results showed that the soil mould populations in the two areas studied are fairly homogeneous and no special trend is shown for dominance of a particular horizon by a special fungus. Findings suggest that is it not safe to assume that all species of fungi recognizable with the technique used appeared on the isolation plates because of a limited number of isolations from a limited number of samples.
KW - Soil fungi
KW - POPULATION biology
KW - Species diversity
KW - Plant species
KW - Soils
KW - Botany
KW - Fungi
KW - Fungal communities
KW - Mycological surveys
KW - Alaska, Southeast
KW - Alaska
KW - United States
N1 - Accession Number: 32005578; Cooke, WM. Bridge 1; Lawrence, Donald B. 2; Affiliations: 1 : Robert A. Taft Sanitary Engineering Center, Bureau of State Services, Public Health Service U.S. Department of Health, Education and Welfare, Cincinnati, Ohio; 2 : Department of Botany, University of Minnesota, Minneapolis 14, Minnesota; Source Info: Oct1959, Vol. 47 Issue 3, p529; Thesaurus Term: Soil fungi; Thesaurus Term: POPULATION biology; Thesaurus Term: Species diversity; Thesaurus Term: Plant species; Thesaurus Term: Soils; Thesaurus Term: Botany; Subject Term: Fungi; Subject Term: Fungal communities; Subject Term: Mycological surveys; Subject: Alaska, Southeast; Subject: Alaska; Subject: United States; Number of Pages: 21p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=8gh&AN=32005578&site=ehost-live&scope=site
DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
ID - 1960-06224-001
AN - 1960-06224-001
AU - Astin, Alexander W.
T1 - A factor study of the MMPI psychopathic deviate scale.
JF - Journal of Consulting Psychology
JO - Journal of Consulting Psychology
JA - J Consult Psychol
Y1 - 1959/12//
VL - 23
IS - 6
SP - 550
EP - 554
CY - US
PB - American Psychological Association
SN - 0095-8891
N1 - Accession Number: 1960-06224-001. Other Journal Title: Journal of Consulting and Clinical Psychology. Partial author list: First Author & Affiliation: Astin, Alexander W.; United States Public Health Service Hosp., Lexington, Ky. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 19600401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Minnesota Multiphasic Personality Inventory. Minor Descriptor: Antisocial Personality Disorder. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Dec, 1959. Copyright Statement: American Psychological Association. 1959.
AB - Ss were 250 male drug addicts. Factor analysis revealed that Pd scores have varied clinical implications depending on internal factors contributing to the total Pd score. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - male drug addicts
KW - clinical implications
KW - Minnesota Multiphasic Personality Inventory psychopathic deviate scale
KW - 1959
KW - Drug Addiction
KW - Minnesota Multiphasic Personality Inventory
KW - Antisocial Personality Disorder
KW - 1959
DO - 10.1037/h0046523
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-06224-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Heller, John R.
T1 - Recent developments in research on cancer.
JO - Geriatrics
JF - Geriatrics
Y1 - 1960/01//
VL - 15
IS - 1
M3 - Article
SP - 1
EP - 10
SN - 0016867X
N1 - Accession Number: 20789589; Heller, John R. 1,2; Source Information: Jan1960, Vol. 15 Issue 1, p1; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 4107
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20789589&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1960-08153-001
AN - 1960-08153-001
AU - Handlon, Joseph H.
T1 - A metatheoretical view of assumptions regarding the etiology of schizophrenia: Implications for research.
JF - A.M.A. Archives of General Psychiatry
JO - A.M.A. Archives of General Psychiatry
JA - AMA Arch Gen Psychiatry
Y1 - 1960/01//
VL - 2
SP - 53
EP - 70
CY - US
PB - American Medical Association
SN - 0375-8532
N1 - Accession Number: 1960-08153-001. Other Journal Title: Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Handlon, Joseph H.; Public Health Service, Bethesda, Md. Release Date: 19600501. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 18. Issue Publication Date: Jan, 1960.
KW - SCHIZOPHRENIA
KW - ETIOLOGY OF
KW - METATHEORETICAL VIEW OF
KW - PSYCHOSES
KW - 1960
KW - No terms assigned
KW - 1960
DO - 10.1001/archpsyc.1960.03590070045006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-08153-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1960-08515-001
AN - 1960-08515-001
AU - Howell, Margaret A.
AU - Cliff, Norman
AU - Newman, Sidney H.
T1 - Further validation of methods for evaluating the performance of physicians.
JF - Educational and Psychological Measurement
JO - Educational and Psychological Measurement
JA - Educ Psychol Meas
Y1 - 1960///
VL - 20
SP - 69
EP - 78
CY - US
PB - Sage Publications
SN - 0013-1644
SN - 1552-3888
N1 - Accession Number: 1960-08515-001. Partial author list: First Author & Affiliation: Howell, Margaret A.; United States Public Health Service, Washington, D. C. Release Date: 19600501. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 10. Issue Publication Date: 1960.
AB - An experimental Efficiency Report criterion-keyed and validated on professional health personnel was highly predictive of work performance given medical interns in United States Public Health Service hospital. 'Multiple correlations between sections of the Efficiency Report and the separate criterion ratings performed by physicians and by interns ranged from .61 to .83… . two sections of the Efficiency Report, 50 Forced-Choice tetrads (FC) and a 22-item Check List (CL), were more valid measures of performance than were rating scales for evaluating an intern's Job Proficiency (JP) and Personal Qualifications (PQ). Beta weights derived from the intern data and applied to the physician's data, and the reverse, produced satisfactory multiple correlations. Equal weights produced a multiple correlation of .66 which was as high as any of those resulting from cross-application of beta weights and only .02 lower than the self-weighted multiple for this group.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PHYSICIAN
KW - PERFORMANCE EVALUATION OF
KW - VALIDATION OF
KW - JOB PERFORMANCE
KW - EVALUATION
KW - FOR PHYSICIANS
KW - VALIDATION OF METHODS OF
KW - PROFESSIONS
KW - 1960
KW - No terms assigned
KW - 1960
DO - 10.1177/001316446002000107
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1960-08515-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1961-03640-001
AN - 1961-03640-001
AU - Klerman, Gerald L.
AU - Sharaf, Myron R.
AU - Holzman, Mathilda
AU - Levinson, Daniel J.
T1 - Sociopsychological characteristics of resident psychiatrists and their use of drug therapy.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1960///
VL - 117
SP - 111
EP - 117
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1961-03640-001. PMID: 14409815 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Klerman, Gerald L.; United States Public Health Service, Bethesda, Md. Release Date: 19610301. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Health & Mental Health Treatment & Prevention (3300). Page Count: 7. Issue Publication Date: 1960.
KW - PSYCHIATRY
KW - DRUG THERAPY
KW - & PSYCHIATRISTS CHARACTERISTICS
KW - DRUG
KW - THERAPY
KW - WITH CONCENTRATION DEFECTS
KW - PSYCHIATRIST'S CHARACTERISTIC
KW - PSYCHIATRIC SERVICES
KW - MEDICAL THERAPY
KW - 1960
KW - No terms assigned
KW - 1960
DO - 10.1176/ajp.117.2.111
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-03640-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1961-06272-001
AN - 1961-06272-001
AU - Lantis, Margaret
T1 - Vernacular culture.
JF - American Anthropologist
JO - American Anthropologist
JA - Am Anthropol
Y1 - 1960///
VL - 62
SP - 202
EP - 216
CY - US
PB - University of California Press
SN - 0002-7294
SN - 1548-1433
N1 - Accession Number: 1961-06272-001. Partial author list: First Author & Affiliation: Lantis, Margaret; United States Public Health Service. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19610501. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Processes & Social Issues (2900). Page Count: 15. Issue Publication Date: 1960.
AB - Particularly in public places people from different social, occupational, and ethnic sources are guided in personal modes of expression by an aspect of complex cultures that has been relatively neglected. Study of this vernacular culture would focus on overt acts and artifacts and on their cultural meaning. For example, one might examine the receptionist-switchboard operator's little domain in a business organization to learn what cues are used in judging status of callers, to observe changes in manner of address to inside versus noncompany visitors, and to understand the caller's responsive assumption of appropriate manner and speech. Present status and available methods of such research are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PUBLIC BEHAVIOR
KW - INFLUENCED BY VERNACULAR CULTURE
KW - CULTURE
KW - VERNACULAR
KW - CULTURAL FACTORS
KW - 1960
KW - No terms assigned
KW - 1960
DO - 10.1525/aa.1960.62.2.02a00020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-06272-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1961-01015-001
AN - 1961-01015-001
AU - Locke, Ben Z.
AU - Kramer, Morton
AU - Pasamanick, Benjamin
T1 - Alcoholic psychoses among first admissions to public mental hospitals in Ohio.
JF - Quarterly Journal of Studies on Alcohol
JO - Quarterly Journal of Studies on Alcohol
JA - Q J Stud Alcohol
Y1 - 1960///
VL - 21
SP - 457
EP - 474
CY - US
PB - Alcohol Research Documentation
SN - 0033-5649
N1 - Accession Number: 1961-01015-001. PMID: 13762978 Other Journal Title: Journal of Studies on Alcohol; Journal of Studies on Alcohol and Drugs. Partial author list: First Author & Affiliation: Locke, Ben Z.; United States Public Health Service, Washington, D.C. Release Date: 19610101. Correction Date: 20081124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 18. Issue Publication Date: 1960.
AB - For 1948-1952 rates were higher for males (14.8 per 100,000) than for females (3.4), nonwhites than whites, single than married, the less well-schooled, and male laborers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHOSIS
KW - ALCOHOLIC
KW - ADMISSION RATES FOR
KW - ALCOHOLIC PSYCHOSES
KW - ADMISSION
KW - RATES
KW - FOR ALCOHOLIC PSYCHOSES
KW - NEUROLOGICAL DISORDERS
KW - 1960
KW - No terms assigned
KW - 1960
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-01015-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1961-01138-001
AN - 1961-01138-001
AU - Klaf, Franklin S.
AU - Davis, Charles A.
T1 - Homosexuality and paranoid schizophrenia: A survey of 150 cases and controls.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1960///
VL - 116
SP - 1070
EP - 1075
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1961-01138-001. PMID: 14409564 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Klaf, Franklin S.; United States Public Health Service Hosp., Fort Worth, Tex. Release Date: 19610101. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 6. Issue Publication Date: 1960.
AB - Data obtained from a study of the records of 150 paranoid schizophrenic patients were compared with a control group of 150 nonpsychiatric patients in relation to Freud's hypothesis about the development of paranoid symptoms. It is concluded that the present study has not verified the hypothesis that paranoia develops as a defense against unconscious homosexual wishes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PARANOID SCHIZOPHRENIA
KW - HOMOSEXUALITY
KW - PSYCHOSES
KW - 1960
KW - No terms assigned
KW - 1960
DO - 10.1176/ajp.116.12.1070
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-01138-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 1961-01170-000
AN - 1961-01170-000
AU - Bell, J. E.
AU - Biber, Barbara
AU - Harsh, J. R.
AU - Hilgard, E. R.
AU - Klopfer, B.
AU - Thomas, L. G.
T1 - New directions in learning: Contributions of philosophy, psychology, and education.
Y1 - 1960///
CY - Oxford, England
PB - California Association of School Ps
N1 - Accession Number: 1961-01170-000. Partial author list: First Author & Affiliation: Bell, J. E.; United States Public Health Service, San Francisco, Calif. Release Date: 19610101. Publication Type: Book (0200). Format Covered: Print. Language: English. Major Descriptor: No terms assigned. Classification: Educational Psychology (3500); General Psychology (2100). Page Count: 104.
AB - A summary of proceedings of the California Association of School Psychologists and Psychometrists held in March 1959. Consists of papers with authors and titles as follows: (a) 'Philosophical Contributions of Our Understanding of Learning' (L. Thomas), (b) 'Recent Contributions of Psychological Theory to Our Understanding of the Learning Process' (E. Hilgard), (c) 'Recent Contributions of Clinical Psychology to Our Understanding of the Learning Process' (J. E. Bell), (d) 'Fact, Fiction, or Probability' (R. Harsh), (e) 'The Implications of Research in Learning for Public Education' (B. Biber), and (f) 'Critique and Overview of Issues of the Conference' (B. Klopfer). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHOLOGY
KW - & SCHOOL LEARNING
KW - PHILOSOPHY
KW - LEARNING
KW - SCHOOL
KW - SYMPOSIUM
KW - EDUCATION
KW - RESEARCH IN LEARNING
KW - EDUCATIONAL PSYCHOLOGY
KW - PHILOSOPHY OF SCIENCE
KW - 1960
KW - No terms assigned
KW - 1960
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-01170-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Butler, Robert N.
T1 - Intensive psychotherapy for the hospitalized aged.
JO - Geriatrics
JF - Geriatrics
Y1 - 1960/09//
VL - 15
IS - 9
M3 - Article
SP - 644
EP - 653
SN - 0016867X
N1 - Accession Number: 20879016; Butler, Robert N. 1,2; Source Information: Sep1960, Vol. 15 Issue 9, p644; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 5071
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=20879016&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - CHAP
ID - 2008-16887-001
AN - 2008-16887-001
AU - Terry, Luther L.
ED - Halsey, Maxwell N.
ED - Halsey, Maxwell N., (Ed)
T1 - The magnitude of the problem.
T2 - Accident prevention: The role of physicians and public health workers.
Y1 - 1961///
SP - 1
EP - 7
CY - New York, NY, US
PB - Blakiston Division/McGraw-Hill Book Company
N1 - Accession Number: 2008-16887-001. Partial author list: First Author & Affiliation: Terry, Luther L.; United States Public Health Service, US. Release Date: 20081222. Correction Date: 20110711. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Accident Prevention; Accidents; Public Health; Safety. Minor Descriptor: Injuries; Physicians; Statistics. Classification: Health & Mental Health Services (3370). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 7.
AB - The decline in deaths from infectious diseases is causing deaths from accidents to appear in bolder relief. The natural result of this phenomenon is an increasing sensitivity on the part of physicians and public health workers of the need to make a greater contribution toward safer living than they have made in the past. Ninety thousand deaths a year and approximately forty-six million injuries indicate the seriousness of the threat of accidents to the American people. Statistics play a valuable role in demonstrating the economic and social cost of accidents; they indicate the variety of circumstances under which accidents occur; and they underline the fact that the problem of accident prevention cannot be coped with by any one group of persons. In this chapter, the author provides a number of statistics describing the problem and includes five steps used in attacking any public health problem. The author closes the chapter by stating that a combined effort by all who can make a contribution, no matter how humble, is essential. When a successful mass movement for safer living does evolve, it is apt to exceed all other health and safety movements in the number and types of people, professions, and interests involved. Accidents and accidental deaths and injuries are that kind of problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - accident prevention
KW - accidents
KW - physicians
KW - safer living
KW - injuries
KW - public health
KW - statistics
KW - 1961
KW - Accident Prevention
KW - Accidents
KW - Public Health
KW - Safety
KW - Injuries
KW - Physicians
KW - Statistics
KW - 1961
DO - 10.1037/13144-001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16887-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-16887-006
AN - 2008-16887-006
AU - Chapman, A. L.
ED - Halsey, Maxwell N.
ED - Halsey, Maxwell N., (Ed)
T1 - Accidents to the aged.
T2 - Accident prevention: The role of physicians and public health workers.
Y1 - 1961///
SP - 80
EP - 92
CY - New York, NY, US
PB - Blakiston Division/McGraw-Hill Book Company
N1 - Accession Number: 2008-16887-006. Partial author list: First Author & Affiliation: Chapman, A. L.; Division of Accident Prevention, U.S. Public Health Service, US. Release Date: 20081222. Correction Date: 20110711. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Accident Prevention; Accidents; Aging. Classification: Promotion & Maintenance of Health & Wellness (3365). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 13.
AB - Old people are particularly susceptible to accidents. Some of the reasons for this are obvious and relate to the physiologic changes associated with aging. The other reasons are much less clear. They relate to attitudes and involve, for example, the fear of losing status if full recognition is given to the disturbing fact of physical and mental decline. Relatively little has been done to delineate the obstacles in motivating older people to live more safely, that is, within the limits of their restricted functional capabilities. In this chapter, the author discusses the topic of accidents and the elderly. The problems are described and suggestions are made regarding research needs. Chapter subheadings include characteristics of elderly people; the parameters of the problem; motor vehicle and pedestrian accidents; and research needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - accident prevention
KW - accidents
KW - aged
KW - 1961
KW - Accident Prevention
KW - Accidents
KW - Aging
KW - 1961
DO - 10.1037/13144-006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16887-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-16887-007
AN - 2008-16887-007
AU - Joliet, Paul V.
AU - Lehr, Eugene L.
ED - Halsey, Maxwell N.
ED - Halsey, Maxwell N., (Ed)
T1 - Home safety.
T2 - Accident prevention: The role of physicians and public health workers.
Y1 - 1961///
SP - 93
EP - 117
CY - New York, NY, US
PB - Blakiston Division/McGraw-Hill Book Company
N1 - Accession Number: 2008-16887-007. Partial author list: First Author & Affiliation: Joliet, Paul V.; Division of Accident Prevention, United States Public Health Service, US. Release Date: 20081222. Correction Date: 20110711. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Accident Prevention; Home Accidents; Safety. Minor Descriptor: Communities; Injuries. Classification: Promotion & Maintenance of Health & Wellness (3365). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 25.
AB - Home accidents are the most frequent cause of injury. One-third of all nonfatal accidental injuries and more than one-fourth of all fatal injuries occur in and around the home. Home accidents, like accidents of other types, can be prevented. But accident prevention work in other fields, such as on the highway and on the job, is far more advanced than preventive activities in the field of home safety. This chapter describes the problems and issues associated with home accidents. The chapter includes the following: factors in home accidents; accidents among children; accidents and the elderly; causes and prevention; responsibility in home safety; and organizing the community in home safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - home accidents
KW - accidental injuries
KW - accident prevention
KW - home safety
KW - community & home safety
KW - 1961
KW - Accident Prevention
KW - Home Accidents
KW - Safety
KW - Communities
KW - Injuries
KW - 1961
DO - 10.1037/13144-007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16887-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-16887-019
AN - 2008-16887-019
AU - Iskrant, Albert P.
ED - Halsey, Maxwell N.
ED - Halsey, Maxwell N., (Ed)
T1 - Fact gathering.
T2 - Accident prevention: The role of physicians and public health workers.
Y1 - 1961///
SP - 350
EP - 361
CY - New York, NY, US
PB - Blakiston Division/McGraw-Hill Book Company
N1 - Accession Number: 2008-16887-019. Partial author list: First Author & Affiliation: Iskrant, Albert P.; Developmental Research Section, Division of Accident Prevention, U.S. Public Health Service, US. Release Date: 20081222. Correction Date: 20110711. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Classic Book; Reference Book. Language: English. Major Descriptor: Accident Prevention; Accidents; Data Collection; Injuries. Minor Descriptor: Health. Classification: Promotion & Maintenance of Health & Wellness (3365). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 12.
AB - Each year the National Health Survey conducts interviews in over 35,000 households. From this source it was estimated that each year about 46 million persons receive injuries that require medical attention or restriction of activities for at least a day. Many health departments rely on accidental injury reporting for estimating components of the accident problem, but a variety of other estimates are available. The method chosen to estimate the extent of the problem and the nature thereof will depend on the amount of detail needed and resources available. Some areas need much local detail, others are satisfied with national estimates to define their problems, applying the numbers to their own population and its characteristics, and giving due consideration to environment. In this chapter, gathering facts to help inform prevention programs or for determining the extent and nature of the accident/injury problem is discussed. Specific areas included are the following: providing facts for prevention programs; base lines and how they measure the effectiveness of programs; sources of data and methods for handling data; types of information; frequency and duration of data-collection activities; and presentation and use of data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - data-collection
KW - accident prevention
KW - injuries
KW - injury reporting
KW - prevention programs
KW - 1961
KW - Accident Prevention
KW - Accidents
KW - Data Collection
KW - Injuries
KW - Health
KW - 1961
DO - 10.1037/13144-019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16887-019&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1961-06325-001
AN - 1961-06325-001
AU - Robbins, P. R.
T1 - Immediate and delayed effects of social influence upon individual opinion.
JF - The Journal of Social Psychology
JO - The Journal of Social Psychology
JA - J Soc Psychol
Y1 - 1961///
VL - 53
SP - 159
EP - 167
CY - US
PB - Heldref Publications
SN - 0022-4545
SN - 1940-1183
N1 - Accession Number: 1961-06325-001. Partial author list: First Author & Affiliation: Robbins, P. R.; United States Dept. Health, Education, & Welfare, Public Health Service. Other Publishers: Taylor & Francis. Release Date: 19610501. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 9. Issue Publication Date: 1961.
AB - The study was designed to explore both immediate and delayed effects of social pressure on individual opinion. Variables considered were the presence of a threat that the individual's opinion would be revealed to the group, the size of the majority supporting the group position, and personality needs of the Ss as measured by the Edwards Personal Preference Schedule. In general, the degree to which Ss were immediately influenced by social pressure was the same whether (a) the size of the majority was larger (86%) or smaller (56%) and (b) the individual was or was not given the expectation that his position would be revealed to the group. Although threat did not have a general effect it had a significant effect on the opinions of Ss who subsequently withdrew from the project. There was a positive relationship between immediate influence scores and subsequent withdrawal from the research project. Delayed influence scores were similar for threat vs. non-threat and for high vs. low majority. Both threat and high majority were positively related to a drop in score from the influence session to the posttest. No significant correlations were found between scores on the Edwards inventory and either immediate or delayed influence scores when computed for the entire sample. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SOCIAL
KW - INFLUENCE
KW - ON INDIVIDUAL OPINION
KW - OPINION
KW - INDIVIDUAL
KW - AS AFFECTED BY SOCIAL INFLUENCE
KW - ATTITUDES
KW - 1961
KW - No terms assigned
KW - 1961
DO - 10.1080/00224545.1961.9922112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1961-06325-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1962-01790-001
AN - 1962-01790-001
AU - Newman, Sidney H.
AU - Howell, Margaret A.
T1 - Validity of forced-choice items for obtaining references on physicians.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1961///
VL - 8
SP - 367
EP - 367
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1962-01790-001. Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service. Other Publishers: Sage Publications. Release Date: 19620101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 1. Issue Publication Date: 1961.
AB - Validity data from a 'reference statement' of 10-forced-choice tetrads were obtained from a population of 128 Public Health Service commissioned medical officers. 'Validities for the Reference Statement are low but significant against all criteria except the forced-choice section of the OER (Officer Efficiency Report).' From Psyc Abstracts 36:01:1LD67N. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MEDICINE
KW - PHYSICIAN
KW - FORCED-CHOICE EVALUATION
KW - FORCED CHOICE
KW - EVALUATION OF PHYSICIANS
KW - SELECTION
KW - PLACEMENT
KW - APPRAISAL
KW - 1961
KW - No terms assigned
KW - 1961
DO - 10.2466/pr0.1961.8.2.367
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1962-01790-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1962-06892-001
AN - 1962-06892-001
AU - Painting, D. H.
T1 - The performance of psychopathic individuals under conditions of positive and negative partial reinforcement.
JF - The Journal of Abnormal and Social Psychology
JO - The Journal of Abnormal and Social Psychology
JA - J Abnorm Soc Psychol
Y1 - 1961/03//
VL - 62
IS - 2
SP - 352
EP - 355
CY - US
PB - American Psychological Association
SN - 0096-851X
N1 - Accession Number: 1962-06892-001. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Painting, D. H.; United States Public Health Service Hosp., Lexington, Ky. Release Date: 19620401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antisocial Personality Disorder; Differential Reinforcement; Positive Reinforcement; Reinforcement Schedules. Minor Descriptor: Neuroticism. Classification: Personality Disorders (3217). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: Mar, 1961. Copyright Statement: American Psychological Association. 1961.
AB - Previous theorizing had distinguished a group of primary psychopaths (PP) from neurotic psychopaths (NP) on the basis of weakness of conscience and disregard for social law (PP) vs. a strong conscience with need to get caught and be punished (NP). The present study is an attempt to distinguish NPs from PPs with regard to their ability to profit from experience (in this instance to profit from differential reinforcement schedules in a learning situation). NPs were seen to be not too different from a control group of normals. However, PPs manifested rigidity of thinking under certain conditions of reinforcement (reward vs. punishment, immediate vs. delayed), and their performance deteriorated the greater the time between stimulus and response. The study, moreover, pointed up the lack of homogeneity in groups grossly defined as 'psychopath.' From Psyc Abstracts 36:04:4JJ53P. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - negative partial reinforcement
KW - psychopathic individuals
KW - positive reinforcement
KW - neurotic psychopaths
KW - 1961
KW - Antisocial Personality Disorder
KW - Differential Reinforcement
KW - Positive Reinforcement
KW - Reinforcement Schedules
KW - Neuroticism
KW - 1961
DO - 10.1037/h0048062
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1962-06892-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Keller, Martin D.
AU - Smith, Charlotte E.
T1 - Meals on wheels: 1960.
JO - Geriatrics
JF - Geriatrics
Y1 - 1961/05//
VL - 16
IS - 5
M3 - Article
SP - 237
EP - 247
SN - 0016867X
N1 - Accession Number: 17120915; Keller, Martin D. 1; Smith, Charlotte E. 2; Source Information: May1961, Vol. 16 Issue 5, p237; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 5957
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17120915&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Suster, E.
AU - Kirsanow, Eugene M.
T1 - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions.
JO - Immunology
JF - Immunology
Y1 - 1961/10//
VL - 4
IS - 4
M3 - Article
SP - 354
EP - 365
SN - 00192805
AB - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - IMMUNE response
KW - MYCOBACTERIA
KW - BACTERIAL toxins
KW - ANTIGEN-antibody reactions
KW - MICE as carriers of disease
KW - IMMUNOLOGY
N1 - Accession Number: 12534120; Suster, E. 1,2; Kirsanow, Eugene M. 1,2; Source Information: Oct61, Vol. 4 Issue 4, p354; Subject: ENDOTOXINS; Subject: IMMUNE response; Subject: MYCOBACTERIA; Subject: BACTERIAL toxins; Subject: ANTIGEN-antibody reactions; Subject: MICE as carriers of disease; Subject: IMMUNOLOGY; Number of Pages: 12p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=12534120&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2006-00786-007
AN - 2006-00786-007
AU - Stricker, George
T1 - Word values, word frequency, and visual duration thresholds: A comment.
JF - Psychological Review
JO - Psychological Review
JA - Psychol Rev
Y1 - 1961/11//
VL - 68
IS - 6
SP - 420
EP - 422
CY - US
PB - American Psychological Association
SN - 0033-295X
SN - 1939-1471
N1 - Accession Number: 2006-00786-007. Partial author list: First Author & Affiliation: Stricker, George; National Institute of Mental Health, United States Public Health Service, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Semantic Differential; Thresholds; Visual Acuity; Word Frequency. Minor Descriptor: Words (Phonetic Units). Classification: Human Experimental Psychology (2300). References Available: Y. Page Count: 3. Issue Publication Date: Nov, 1961. Copyright Statement: American Psychological Association. 1961.
AB - Comments on an article by Johnson, Thomson, and Frincke (see record [rid]2005-10341-002[/rid]). Johnson, Thomson, and Frincke's interpretation of their work with regard to the interrelationships of word value and word frequency was questioned on the basis of their use of the good-bad scale of the semantic differential as an operational definition of word value. Reference to pertinent previous studies seemed to indicate that word value has a directly motivational connotation while the evaluative dimension of the semantic differential is sensitive to an attitudinal, cognitive component of behavior. An examination of their interpretations of their experimental evidence revealed a failure to take this distinction into account. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - word values
KW - word frequency
KW - visual duration thresholds
KW - interrelationships
KW - semantic differential
KW - 1961
KW - Semantic Differential
KW - Thresholds
KW - Visual Acuity
KW - Word Frequency
KW - Words (Phonetic Units)
KW - 1961
DO - 10.1037/h0039126
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00786-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-17966-001
AN - 2011-17966-001
AU - Kelley, Harold H.
AU - Thibaut, John W.
AU - Radloff, Roland
AU - Mundy, David
T1 - The development of cooperation in the 'minimal social situation'.
JF - Psychological Monographs: General and Applied
JO - Psychological Monographs: General and Applied
JA - Psychol Monogr
Y1 - 1962///
VL - 76
IS - 19
SP - 1
EP - 19
CY - US
PB - American Psychological Association
SN - 0096-9753
N1 - Accession Number: 2011-17966-001. Other Journal Title: Psychological Monographs; The Psychological Monographs; The Psychological Review: Monograph Supplements. Partial author list: First Author & Affiliation: Kelley, Harold H.; University of California, Los Angeles, CA, US. Other Publishers: Macmillan & Company; Psychological Review Company; The Macmillan Company; The Review Publishing Company. Release Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cooperation; Dyads; Social Interaction. Minor Descriptor: Research Setting. Classification: Group & Interpersonal Processes (3020). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: 1962. Publication History: First Submitted Date: Aug 20, 1961.
AB - The studies presented in this paper had several purposes. We wished first to determine whether the earlier conclusions about the development of cooperation in the minimal situation would be sustained in different laboratories under slightly different experimental conditions. Two subjects were seated alone in separate rooms, each facing a control box on which was mounted a three-position lever-action switch. On presentation of a signal to start (a white light), each moved his switch in one of two directions from the center position, cither away from or toward himself, and then returned it to the center. The subjects were volunteer college students from introductory psychology classes. Usable data were obtained from a total of 96 dyads. In 16 of the 30 dyads, both subjects obtain more rewards from their partners in the final block of the training than in the first block. In line with the theoretical analysis presented earlier, result indicates that the simultaneous, minimal results are markedly superior to those from the alternation, minimal dyads. Self-report data suggest that this superiority is a consequence of an individual's taking account of his partner's likely reactions to reward versus punishment. Some subjects assume their partners will adhere to the win-stay, lose-change rule and use this to make tests of how their own responses affect the partner. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cooperation development
KW - minimal social situation
KW - experimental conditions
KW - dyads
KW - 1962
KW - Cooperation
KW - Dyads
KW - Social Interaction
KW - Research Setting
KW - 1962
U1 - Sponsor: National Science Foundation. Grant: G-55S3. Recipients: No recipient indicated
DO - 10.1037/h0093819
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-17966-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1963-05528-001
AN - 1963-05528-001
AU - Heinzelmann, Fred
T1 - Factors in prophylaxis behavior in treating rheumatic fever: An exploratory study.
JF - Journal of Health & Human Behavior
JO - Journal of Health & Human Behavior
Y1 - 1962///
VL - 3
IS - 2
SP - 73
EP - 81
CY - US
PB - American Sociological Assn
N1 - Accession Number: 1963-05528-001. Other Journal Title: Journal of Health and Social Behavior. Partial author list: First Author & Affiliation: Heinzelmann, Fred; US Public Health Service. Other Publishers: Sage Publications. Release Date: 19630301. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 9. Issue Publication Date: 1962.
AB - Interviews were held with 284 college students who had a history of rheumatic fever and/or rheumatic heart disease. The goal was to discover factors which differentiate persons who maintain prophylaxis from those who do not. 'Four general categories were considered in the analysis of the data: psychological factors, medical factors, sociological factors, and factors relative to the contact between the individual and physicians.' Conclusion: 'it is a person's subjective definition of his health situation as reflected in these beliefs rather than objective fact which is of primary importance in influencing his behavior. Any efforts which are made to promote the acceptance of prophylaxis must, therefore, be focused upon the frame of reference of the individual who has a history of rheumatic fever.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - STUDENT/COLLEGE
KW - HEART DISEASE & PROPHYLAXIS
KW - MEDICINE
KW - PROPHYLAXIS BEHAVIOR
KW - HEART
KW - RHEUMATIC FEVER
KW - PSYCHOSOMATICS
KW - 1962
KW - No terms assigned
KW - 1962
DO - 10.2307/2948926
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1963-05528-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1965-01524-001
AN - 1965-01524-001
AU - Lefcourt, H. M.
T1 - Clinical correlates of dogmatism.
JF - Journal of Clinical Psychology
JO - Journal of Clinical Psychology
JA - J Clin Psychol
Y1 - 1962///
VL - 18
IS - 3
SP - 327
EP - 328
CY - US
PB - John Wiley & Sons
SN - 0021-9762
SN - 1097-4679
N1 - Accession Number: 1965-01524-001. Other Journal Title: In Session: Psychotherapy in Practice. Partial author list: First Author & Affiliation: Lefcourt, H. M.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19650101. Correction Date: 20130624. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 2. Issue Publication Date: 1962.
AB - Dogmatism and readiness for therapy through potential for change was investigated. 272 drug addict Ss representing neurotic, character disorder, and psychotic groups were administered a number of psychological tests and a dogmatism scale. Dogmatism increased in Ss less apt to change. Validity of the dogmatism construct as related to predicting receptivity to and success in counseling was supported. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DOGMATISM
KW - CLINICAL CORRELATES OF
KW - ATTITUDES & OPINIONS
KW - 1962
KW - No terms assigned
KW - 1962
DO - 10.1002/1097-4679(196207)18:3<327::AID-JCLP2270180327>3.0.CO;2-B
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-01524-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-00848-001
AN - 1964-00848-001
AU - Robbins, Paul R.
T1 - Self-reports of reactions to fear-arousing information.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1962///
VL - 11
IS - 3
SP - 761
EP - 764
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1964-00848-001. Partial author list: First Author & Affiliation: Robbins, Paul R.; Behavioral Science Section, Public Health Service. Other Publishers: Sage Publications. Release Date: 19640101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Social Psychology (3000). Page Count: 4. Issue Publication Date: 1962.
AB - 555 students 'were exposed to portions of a specially devised tape recording concerning cancer, and assessed for reactions using selfreport techniques. Analyses were made of the relationship of anxiety level created by the stimulus and report of defensive reactions. There was some evidence indicating that anxiety was positively related to attention and aggression, and unrelated to desire for avoidance.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - INFORMATION
KW - FEARFUL
KW - ON CANCER
KW - & REACTIONS TO
KW - FEAR
KW - AROUSING INFORMATION
KW - REACTIONS TO
KW - CANCER
KW - & FEAR REACTIONS
KW - ATTITUDES & OPINIONS
KW - 1962
KW - No terms assigned
KW - 1962
DO - 10.2466/pr0.1962.11.3.761
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-00848-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-04489-001
AN - 1964-04489-001
AU - Davis, C. H.
AU - Jenkins, C. D.
T1 - Mental stress and oral disease.
JF - Journal of Dental Research
JO - Journal of Dental Research
Y1 - 1962///
VL - 41
IS - 5
SP - 1045
EP - 1049
N1 - Accession Number: 1964-04489-001. Partial author list: First Author & Affiliation: Davis, C. H.; US Public Health Service, Washington, D. C. Release Date: 19640301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 5. Issue Publication Date: 1962.
AB - 89 successive admissions to a psychiatric hospital were administered the MMPI and a dental exam. While the DMF score (decayed-missing-filled) was unrelated to psychopathology, the Periodontal Index correlated .60 with the Welsh Anxiety scale. (32 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PSYCHIATRIC PATIENT
KW - DENTAL DISEASE IN
KW - MINNESOTA MULTIPHASIC PERSONALITY INVENTORY (MMPI)
KW - & DENTAL DISORDERS
KW - ABNORMAL PSYCHOLOGY
KW - 1962
KW - No terms assigned
KW - 1962
DO - 10.1177/00220345620410050601
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-04489-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ake, James N.
T1 - A RAPID MACHINE PROCEDURE FOR DETERMINING SCALABILITY OF ANY NUMBER OF QUESTIONS.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1962///Spring62
VL - 26
IS - 1
M3 - Article
SP - 121
EP - 125
SN - 0033362X
AB - In 1950 Robert Ford discussed machine routines for Guttman scaling in the journal "Public Opinion Quarterly," using the IBM counting sorter and tabulator. The present article presents a machine routine that follows Ford's general scheme but uses the IBM Electronic Statistical Machine-Type 101. The machine procedure described in the article is simpler and more rapid than the counting-sorter or tabulator techniques. A series of dichotomized questions taken three at a time can be scored and the scores arrayed at a rate of approximately 225 responses per minute through the use of the IBM 101. Following Ford's scoring method, positive responses to successive questions are given weights of 1, 2, 4, 8, 16, 32, and so on, with the question having the largest number of positive responses carrying the smallest weight and the question with the fewest number of positive responses, the largest weight; all negative responses are scored zero. Thus, any combination of positive and negative responses has its own distinct score. To simplify the discussion, the problem of scaling six questions is considered. Any number of questions may be scaled, although the process becomes cumbersome with more than six.
KW - Statistics
KW - Surveys
KW - Questionnaires
KW - Social sciences
KW - Ford, Robert N.
KW - Public Opinion Quarterly (Periodical)
N1 - Accession Number: 11956203; Ake, James N. 1; Affiliations: 1: Statistician in the Division of Dental Public Health and Resources, Public Health Service, U.S. Department of Health, Education and Welfare.; Issue Info: Spring62, Vol. 26 Issue 1, p121; Thesaurus Term: Statistics; Thesaurus Term: Surveys; Thesaurus Term: Questionnaires; Subject Term: Social sciences; Reviews & Products: Public Opinion Quarterly (Periodical); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; People: Ford, Robert N.; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=11956203&site=ehost-live&scope=site
DP - EBSCOhost
DB - ufh
ER -
TY - GEN
AU - Gross, Seymour
T1 - LETTERS.
JO - Scientific American
JF - Scientific American
Y1 - 1962/03//
VL - 206
IS - 3
M3 - Letter
SP - 10
EP - 10
SN - 00368733
AB - A letter to the editor is presented in response to the article about the aggressive behavior of animals by Irenäus Eibl-Eibesfeldt in the December 1961 issue.
KW - Animal behavior
KW - Letters to the editor
N1 - Accession Number: 19839187; Gross, Seymour 1; Affiliations: 1: U.S. Public Health Service Trainee, Clinical Psychology, Minneapolis, Minn.; Issue Info: Mar1962, Vol. 206 Issue 3, p10; Thesaurus Term: Animal behavior; Subject Term: Letters to the editor; Number of Pages: 2/3p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19839187&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boyd, Robert J.
AU - Connolly, John E.
T1 - The effect of hypothermia in experimental cerebral ischemia.
JO - Geriatrics
JF - Geriatrics
Y1 - 1962/08//
VL - 17
IS - 8
M3 - Article
SP - 522
EP - 527
SN - 0016867X
N1 - Accession Number: 17120770; Boyd, Robert J. 1; Connolly, John E. 2; Source Information: Aug1962, Vol. 17 Issue 8, p522; Number of Pages: 6p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Chart; Document Type: Article; Full Text Word Count: 2279
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17120770&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Knott, Leslie W.
T1 - The case for care outside the institution.
JO - Geriatrics
JF - Geriatrics
Y1 - 1962/08//
VL - 17
IS - 8
M3 - Article
SP - 532
EP - 537
SN - 0016867X
N1 - Accession Number: 17120774; Knott, Leslie W. 1; Source Information: Aug1962, Vol. 17 Issue 8, p532; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 2835
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17120774&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Ortmeyer, Carl E.
T1 - MARRIAGE AND DIVORCE STATISTICS PROGRAMS OF THE NATIONAL VITAL STATISTICS DIVISION -- CURRENT DEVELOPMENTS AND RESEARCH POTENTIALS.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1962/10//
VL - 27
IS - 5
M3 - Article
SP - 741
EP - 746
SN - 00031224
AB - The article discusses marriage and divorce statistics in the United States. The United States has lagged behind most nations of the Western World in the development of a nationwide organization for registering, collecting, and analyzing data about marriages and divorces. In the 1958 issue of the "Demographic Yearbook" of the United Nations', the data on marriages from the United States represented coverage of less than 90 percent of all marriages occurring in that year. Coverage of marriages was reported as more complete in most nations of North and Central America, and Western and Central Europe, than in the United States. The picture was similar for coverage of divorce data. These facts are the occasion for current efforts to overcome this lag. In the United States, the collection of national marriage and divorce statistics is the responsibility of the U.S. National Vital Statistics Division, a unit National Center for Health Statistics in the Public Health Service. Legislation concerned with marriage and divorce falls in the province of the fifty States.
KW - STATISTICS
KW - MARRIAGE
KW - DIVORCE records
KW - MARITAL satisfaction
KW - FAMILIES
KW - UNITED States
N1 - Accession Number: 12768423; Ortmeyer, Carl E. 1; Affiliations: 1: National Center for Health Statistics, U. S. Public Health Service; Issue Info: Oct62, Vol. 27 Issue 5, p741; Thesaurus Term: STATISTICS; Subject Term: MARRIAGE; Subject Term: DIVORCE records; Subject Term: MARITAL satisfaction; Subject Term: FAMILIES; Subject: UNITED States; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12768423&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Tibbitts, Helen G.
T1 - RESEARCH IN THE DEVELOPMENT OF SOCIOLOGY: A PILOT STUDY IN METHODOLOGY.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1962/12//
VL - 27
IS - 6
M3 - Article
SP - 892
EP - 901
SN - 00031224
AB - The question of the effect that federal government support of research may be having upon scientific development in this country is one which deeply interests everyone devoted to extending the boundaries of knowledge. This is a large and complex problem, and no satisfactory measures of effect exist. In the meantime, it appears pertinent to inquire into the extent to which current contributions to the development of specific scientific fields have come from work which has been financed in part at least from sources outside of the investigator's own institution. This article attempts a pilot analysis of this latter problem for the field of sociology. The problem of this report requires, first, some means of identifying contributions to the development of sociology, then, data on external support, and finally, a system for classifying the nature of the contribution. The first two requirements are met relatively satisfactorily if it is assumed, and this seems a reasonable assumption, that the editorial boards of national sociological journals select articles for publication on the basis of their scientific contribution, and accordingly these articles have been used as the data to be analyzed.
KW - RESEARCH grants
KW - SOCIOLOGICAL research
KW - SOCIOLOGY
KW - PERIODICALS
KW - METHODOLOGY
KW - SOCIAL sciences
N1 - Accession Number: 12788946; Tibbitts, Helen G. 1; Affiliations: 1: U. S. Public Health Service; Issue Info: Dec62, Vol. 27 Issue 6, p892; Thesaurus Term: RESEARCH grants; Subject Term: SOCIOLOGICAL research; Subject Term: SOCIOLOGY; Subject Term: PERIODICALS; Subject Term: METHODOLOGY; Subject Term: SOCIAL sciences; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 813219 Other Grantmaking and Giving Services; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1964-04759-001
AN - 1964-04759-001
AU - Howell, Margaret A.
T1 - Developing a single forced-choice performance evaluation key for several professional groups.
JF - Personnel Psychology
JO - Personnel Psychology
JA - Pers Psychol
Y1 - 1963///
VL - 16
IS - 2
SP - 157
EP - 161
CY - United Kingdom
PB - Blackwell Publishing
SN - 0031-5826
SN - 1744-6570
N1 - Accession Number: 1964-04759-001. Partial author list: First Author & Affiliation: Howell, Margaret A.; US Public Health Service, Washington, D. C. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19640301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Industrial & Organizational Psychology (3600). Page Count: 5. Issue Publication Date: 1963.
AB - Item analyses of 50 forced-choice tetrads against co-workers ratings of commissioned officers in the Public Health Service resulted in 5 different professional-occupational scoring keys. 6 additional keys were derived from the scoring weights in the 5 operational keys. Intercorrelations among the keys and with various criteria indicated that it was possible to develop a single key for a number of professions which was as valid as the separate occupational keys. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PERSONNEL
KW - PUBLIC HEALTH
KW - EVALUATION OF
KW - KEY FOR
KW - JOB PERFORMANCE
KW - FORCED-CHOICE KEY FOR
KW - SELECTION
KW - PLACEMENT
KW - APPRAISAL
KW - 1963
KW - No terms assigned
KW - 1963
DO - 10.1111/j.1744-6570.1963.tb01265.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-04759-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-10268-001
AN - 1964-10268-001
AU - Levine, Jerome
AU - Ludwig, Arnold M.
AU - Lyle, William H. Jr.
T1 - The controlled psychedelic state.
JF - American Journal of Clinical Hypnosis
JO - American Journal of Clinical Hypnosis
JA - Am J Clin Hypn
Y1 - 1963///
VL - 6
IS - 2
SP - 163
EP - 164
CY - US
PB - American Society of Clinical Hypnosis
SN - 0002-9157
SN - 2160-0562
N1 - Accession Number: 1964-10268-001. Partial author list: First Author & Affiliation: Levine, Jerome; US Public Health Service Hosp., Lexington, Ky. Other Publishers: Taylor & Francis. Release Date: 19640601. Correction Date: 20120702. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hypnosis; Hypnotherapy; Lysergic Acid Diethylamide. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1963.
AB - In an attempt better to control the LSD-25 experience for therapeutic purposes, the authors have developed a technique which combines the use of hypnosis with administration of the drug. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hypnosis
KW - psychedelic state
KW - lysergic acid diethylamide
KW - 1963
KW - Hypnosis
KW - Hypnotherapy
KW - Lysergic Acid Diethylamide
KW - 1963
DO - 10.1080/00029157.1963.10402334
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-10268-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-02385-001
AN - 1964-02385-001
AU - Vaillant, George E.
T1 - Twins discordant for early infantile autism.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1963///
VL - 9
IS - 2
SP - 163
EP - 167
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1964-02385-001. Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Vaillant, George E.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19640201. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Developmental Psychology (2800). Page Count: 5. Issue Publication Date: 1963.
AB - The cases of 2 pairs of twins age 11 and 15 at the time of reporting are presented. For the heterozygous autistic twin there are indications for possible hereditary determinants of impaired language acquisition. The case of the 'probably homozygous' twin 'suggests that, although genetic factors may play a part, in some cases the syndrome of infantile autism appears to be a reversible one.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - TWINS
KW - INFANTILE AUTISM IN
KW - INFANCY
KW - AUTISM IN
KW - TWIN
KW - AUTISM
KW - INFANTILE
KW - IN TWIN
KW - 1963
KW - No terms assigned
KW - 1963
DO - 10.1001/archpsyc.1963.01720140059009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-02385-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-04615-001
AN - 1964-04615-001
AU - Nickols, John
T1 - Mental deficit, schizophrenia and the Benton Test.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1963///
VL - 136
IS - 3
SP - 279
EP - 282
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 1964-04615-001. Partial author list: First Author & Affiliation: Nickols, John; US Public Health Service Outpatient Clinic, Washington, D. C. Release Date: 19640301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychological & Physical Disorders (3200). Page Count: 4. Issue Publication Date: 1963.
AB - 'Forty-four chronic schizophrenics and seventeen neurotics were administered the Benton Visual Retention test and a short form of the Wechsler Adult Intelligence Scale. Deficit scores were determined by subtracting the Benton score from the WAIS score. A necessary conclusion is that, while these tests have utility in sampling mental deficit in chronic schizophrenics, it would be difficult to judge the determinant factor on the basis of the categorization of test scores alone.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - TEST/INTELLIGENCE
KW - BENTON VISUAL RETENTION TEST
KW - & SCHIZOPHRENIC DEFICITS
KW - SCHIZOPHRENIA/CHRONIC
KW - MENTAL DEFICIT IN
KW - & BENTON TEST
KW - PSYCHOSES
KW - 1963
KW - No terms assigned
KW - 1963
DO - 10.1097/00005053-196303000-00010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-04615-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1964-03414-001
AN - 1964-03414-001
AU - Haertzen, Charles A.
T1 - Method for direct determination of inverted factor loadings.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1963///
VL - 12
IS - 2
SP - 399
EP - 402
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1964-03414-001. Partial author list: First Author & Affiliation: Haertzen, Charles A.; Public Health Service Hosp., Lexington, Ky. Other Publishers: Sage Publications. Release Date: 19640301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 4. Issue Publication Date: 1963.
AB - 'A procedure is presented for the determination of orthogonal markers and for the direct calculation of inverted factor loadings. Orthogonal markers are determined by deviations from regression.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - FACTOR ANALYSIS
KW - INVERTED FACTOR LOADINGS
KW - METHOD FOR
KW - STATISTICS
KW - 1963
KW - No terms assigned
KW - 1963
DO - 10.2466/pr0.1963.12.2.399
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-03414-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Butler, Robert N.
T1 - Psychiatric evaluation of the aged.
JO - Geriatrics
JF - Geriatrics
Y1 - 1963/03//
VL - 18
IS - 3
M3 - Article
SP - 220
EP - 232
SN - 0016867X
N1 - Accession Number: 17107737; Butler, Robert N. 1; Source Information: Mar1963, Vol. 18 Issue 3, p220; Number of Pages: 13p; Illustrations: 9 Black and White Photographs, 2 Charts; Document Type: Article; Full Text Word Count: 4741
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17107737&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Ehrlich JR., S. Paul
T1 - Epidemiologic approach to chronic disease.
JO - Geriatrics
JF - Geriatrics
Y1 - 1963/07//
VL - 18
IS - 7
M3 - Article
SP - 552
EP - 556
SN - 0016867X
N1 - Accession Number: 17184754; Ehrlich JR., S. Paul 1; Source Information: Jul1963, Vol. 18 Issue 7, p552; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 2283
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17184754&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Wilkie, Charlotte H.
T1 - A Study of Distortions in Recording Interviews.
JO - Social Work
JF - Social Work
Y1 - 1963/07//
VL - 8
IS - 3
M3 - Article
SP - 31
EP - 36
SN - 00378046
AB - This article explores the nature of the caseworkers' "distortions" in their recording of clients' communications about their problems, attitudes and values. The term distortion is used here in its descriptive sense of change of an original form. The problem of distortions is important because of the struggle to reduce the empirical quality of the worker's every day job and to develop an increasingly scientific basis for it. Recent years have seen many research studies aimed at analyzing the subjective quality of the interviewers perception and observations. The availability of verbatim recording by mechanical means has made this possible and easy. In 1944, Bernard J. Covner, a psychologist, made a study of a number of counseling interviews to analyze the accuracy of the written report as against the phonographic recording. This study was again repeated in 1958 by sociologist C.P. Froelich and yielded very much the same results. In general, a large part of client's interview is not recorded but what is recorded is accurate. According to the study, distortions in communication with clients because of lack of familiarity with deeply pathological patterns of behavior are easier to control as new knowledge of these patterns is acquired. It would be helpful to become aware of those unconscious omissions early in contacts, as they are in the service of workers needs other than the client's.
KW - Interviewing
KW - Counseling
KW - Sound recording & reproducing
KW - Communication
KW - Attitude (Psychology)
KW - Quality
KW - Empirical research
N1 - Accession Number: 14204596; Wilkie, Charlotte H. 1; Affiliations: 1: Social worker with the Social Service Department, National Institute of Mental Health, Public Health Service,; Issue Info: Jul63, Vol. 8 Issue 3, p31; Thesaurus Term: Interviewing; Thesaurus Term: Counseling; Thesaurus Term: Sound recording & reproducing; Thesaurus Term: Communication; Thesaurus Term: Attitude (Psychology); Subject Term: Quality; Subject Term: Empirical research; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 512240 Sound Recording Studios; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Hamburger, R. N.
AU - Pious, D. A.
AU - Mills, S. E.
T1 - Antigenic Specificities Acquired from the Growth Medium by Cells in Tissue Culture.
JO - Immunology
JF - Immunology
Y1 - 1963/09//
VL - 6
IS - 5
M3 - Article
SP - 439
EP - 449
SN - 00192805
AB - Studies employing quantitative complement fixation have shown that HeLa and other mammalian cells grown in tissue culture adsorb serum protein components from the growth medium, The serum proteins are not completely removed by vigorous washing, Upon injection of extensively washed cells with rabbits the bound serum proteins give rise to specific antibodies delectable by gel diffusion and complement fixation. With horse serum in the growth medium one of the cell-bound components was identified as horse γ globulin. Evidence was obtained that specific antibodies to bound serum antigens can contribute to complement-dependent kill of the cells in vitro. These observations suggest one possible mechanism for the acquisition of antigenic relationships by diverse cell lines grown in tissue culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLULAR growth
KW - TISSUE culture
KW - CELL lines
KW - IMMUNOGLOBULINS
KW - BLOOD proteins
KW - ANTIGENS
KW - RABBITS as laboratory animals
KW - IMMUNODIFFUSION
N1 - Accession Number: 12800322; Hamburger, R. N. 1; Pious, D. A. 2; Mills, S. E. 3; Source Information: Sep63, Vol. 6 Issue 5, p439; Subject: CELLULAR growth; Subject: TISSUE culture; Subject: CELL lines; Subject: IMMUNOGLOBULINS; Subject: BLOOD proteins; Subject: ANTIGENS; Subject: RABBITS as laboratory animals; Subject: IMMUNODIFFUSION; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - HOWELL, MARGARET A.
AU - NEWMAN, SIDNEY H.
T1 - WHAT FACTORS CONTRIBUTE TO SPECIALIZATION WITHIN PSYCHOLOGY?
JO - Personnel Psychology
JF - Personnel Psychology
Y1 - 1963/12//
VL - 16
IS - 4
M3 - Article
SP - 359
EP - 371
SN - 00315826
AB - The article discusses a study which explored the factors influencing the specialization in the field of psychology, particularly the two specialty groups called clinicians and experimentalists. The study performed a factor-analysis for the ability tests, as well as a professional achievement test battery that covered almost all of the content areas within psychology. Results showed that the professional examination battery can be reduced for selection purposes into clinical and experimental specialty scores. The study suggested that separate specialties' achievement scores can become associated with basic ability patterns.
KW - EXPERTISE
KW - TESTING
KW - OCCUPATIONAL achievement
KW - EXPERIMENTAL psychology
KW - CLINICAL psychology
KW - EXPERIMENTAL psychologists
KW - CLINICAL psychologists
KW - FACTOR analysis
KW - ABILITY testing
KW - ACHIEVEMENT tests
KW - ACADEMIC achievement
N1 - Accession Number: 62839042; HOWELL, MARGARET A. 1; NEWMAN, SIDNEY H. 1; Affiliations: 1: U. S. Public Health Service; Issue Info: Dec1963, Vol. 16 Issue 4, p359; Thesaurus Term: EXPERTISE; Thesaurus Term: TESTING; Thesaurus Term: OCCUPATIONAL achievement; Subject Term: EXPERIMENTAL psychology; Subject Term: CLINICAL psychology; Subject Term: EXPERIMENTAL psychologists; Subject Term: CLINICAL psychologists; Subject Term: FACTOR analysis; Subject Term: ABILITY testing; Subject Term: ACHIEVEMENT tests; Subject Term: ACADEMIC achievement; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/j.1744-6570.1963.tb01282.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - CRESWELL, MARCIA B.
T1 - EFFECTS OF CONFIDENTIALITY ON PERFORMANCE RATINGS OF PROFESSIONAL HEALTH PERSONNEL.
JO - Personnel Psychology
JF - Personnel Psychology
Y1 - 1963/12//
VL - 16
IS - 4
M3 - Article
SP - 385
EP - 393
SN - 00315826
AB - The article presents a study which examines the impact of confidentiality on the ratings of professional health personnel performance. The study employs three collections of Operational Efficiency Reports including the June 1959 Annual Report, the June 1958 Annual Report, and the December 1958 Confidential Report. It mentions that the study focuses on 217 subjects which include 82 Research (RES), 59 Public Health, and 76 Medical Care (MC) officers. The result of the study indicates that thee was fairly high and consistent rating intercorrelations regardless of the reporting conditions involved.
KW - CONFIDENTIAL records
KW - MEDICAL care
KW - JOB performance
KW - DATA analysis
KW - STANDARD deviations
KW - PUBLIC health officers
KW - PERSONAL Attribute Inventory
KW - CHI-squared test
KW - PUBLIC health
N1 - Accession Number: 62839046; CRESWELL, MARCIA B. 1; Affiliations: 1: U. S. Public Health Service; Issue Info: Dec1963, Vol. 16 Issue 4, p385; Thesaurus Term: CONFIDENTIAL records; Thesaurus Term: MEDICAL care; Thesaurus Term: JOB performance; Thesaurus Term: DATA analysis; Thesaurus Term: STANDARD deviations; Subject Term: PUBLIC health officers; Subject Term: PERSONAL Attribute Inventory; Subject Term: CHI-squared test; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1744-6570.1963.tb01284.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1964-08751-001
AN - 1964-08751-001
AU - Ludwig, Arnold M.
AU - Lyle, William H.
T1 - The experimental production of narcotic drug effects and withdrawal symptoms through hypnosis.
JF - International Journal of Clinical and Experimental Hypnosis
JO - International Journal of Clinical and Experimental Hypnosis
JA - Int J Clin Exp Hypn
Y1 - 1964///
VL - 12
IS - 1
SP - 1
EP - 17
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7144
N1 - Accession Number: 1964-08751-001. Partial author list: First Author & Affiliation: Ludwig, Arnold M.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19640501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Withdrawal; Hypnosis; Hypnotic Susceptibility; Narcotic Drugs; Symptoms. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 17. Issue Publication Date: 1964.
AB - The purpose of this study was to evaluate the role of suggestion in the production of certain narcotic drug effects and in the narcotic abstinence syndrome. In addition, we were interested in determining the extent to which actual narcotic drug effects could be reversed through post-hypnotic suggestion. The results of our study indicated that formerly addicted Ss, who had experienced at least one 'cold turkey' withdrawal from narcotics, were able to attain a highly realistic suggested narcotic drug and withdrawal experience through hypnosis with appropriate physiological and behavioral changes, which they were unable to achieve in other control conditions. Moreover, when actual narcotic drugs were administered, certain Ss were able to return to normal behavior following appropriate post-hypnotic suggestions. Hypnosis was deemed to be essential in the production of all these effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - narcotic drug effects
KW - withdrawal symptoms
KW - hypnosis
KW - hypnotic suggestion
KW - 1964
KW - Drug Withdrawal
KW - Hypnosis
KW - Hypnotic Susceptibility
KW - Narcotic Drugs
KW - Symptoms
KW - 1964
DO - 10.1080/00207146408409252
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1964-08751-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1965-01677-001
AN - 1965-01677-001
AU - Monroe, Jack J.
AU - Miller, Jerome S.
AU - Lyle, William H. Jr.
T1 - The extension of psychopathic deviancy scales for the screening of addict patients.
JF - Educational and Psychological Measurement
JO - Educational and Psychological Measurement
JA - Educ Psychol Meas
Y1 - 1964///
VL - 2
IS - 1
SP - 47
EP - 56
CY - US
PB - Sage Publications
SN - 0013-1644
SN - 1552-3888
N1 - Accession Number: 1965-01677-001. Partial author list: First Author & Affiliation: Monroe, Jack J.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19650101. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Individual Differences; Item Analysis (Statistical); Screening. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Page Count: 10. Issue Publication Date: 1964.
AB - 'Through the avenues of factor analysis and item analysis, 6 scales were derived which proved to be useful and reliable dimensions for the distribution and scaling of individual differences among drug addicts on self concepts presumed to be sociopathic. Criterion-derived scales for the reliable measurement of sexual orientation and intellectual status were also developed.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sexual orientation
KW - reliable measurement
KW - reliable dimensions
KW - psychopathic deviancy
KW - item analysis
KW - intellectual status
KW - factor analysis
KW - 1964
KW - Addiction
KW - Individual Differences
KW - Item Analysis (Statistical)
KW - Screening
KW - 1964
DO - 10.1177/001316446402400103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-01677-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1965-02193-001
AN - 1965-02193-001
AU - Ludwig, Arnold M.
AU - Lyle, William H. Jr.
AU - Miller, Jerome S.
T1 - Group hypnotherapy techniques with drug addicts.
JF - International Journal of Clinical and Experimental Hypnosis
JO - International Journal of Clinical and Experimental Hypnosis
JA - Int J Clin Exp Hypn
Y1 - 1964///
VL - 12
IS - 2
SP - 53
EP - 66
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7144
N1 - Accession Number: 1965-02193-001. Partial author list: First Author & Affiliation: Ludwig, Arnold M.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19650101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Hypnotherapy. Classification: Substance Abuse & Addiction (3233); Clinical Hypnosis (3351). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: 1964.
AB - This study was designed to investigate the appropriateness of a number of group hypnotherapeutic techniques which might be used in the treatment of addict patients. It is the belief of the investigators that the more 'magical,' 'authoritative,' and practical-oriented techniques seem more appropriate and useful than techniques designed to elicit deep, insightful understanding of the emotional problems underlying drug addiction. Many of the specific hypnotherapeutic techniques used are described, and some of the difficulties and advantages of group hypnosis as a treatment method are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - group hypnotherapy techniques
KW - drug addicts
KW - 1964
KW - Drug Addiction
KW - Hypnotherapy
KW - 1964
DO - 10.1080/00207146408409259
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-02193-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1965-06578-001
AN - 1965-06578-001
AU - Cohen, Alexander
AU - Baumann, Karl C.
T1 - Temporary hearing losses following exposure to pronounced single-frequency components in broadband noise.
JF - Journal of the Acoustical Society of America
JO - Journal of the Acoustical Society of America
JA - J Acoust Soc Am
Y1 - 1964///
VL - 36
IS - 6
SP - 1167
EP - 1175
CY - US
PB - Acoustical Society of American
SN - 0001-4966
N1 - Accession Number: 1965-06578-001. Partial author list: First Author & Affiliation: Cohen, Alexander; US Public Health Service, Cincinnati, O. Release Date: 19650301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Auditory Stimulation; Auditory Thresholds; Noise Effects; Partially Hearing Impaired. Classification: Auditory & Speech Perception (2326). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: 1964.
AB - Temporary hearing losses were observed for 20-min. exposures to pure-tone frequencies (500, 1000, 2000, 4000 cps), which were independently mixed in various strengths with a broad-band noise to create different exposure conditions involving a strong tonal component in a noise field. The over-all (combined pure-tone/noise) SPL for all conditions was fixed at 105 db and the resultant losses were compared to those caused by equivalent exposures to just the broad-band noise (referred to as the continuous-spectrum-noise condition). The pure-tone/noise combinations produced greater threshold losses than the continuous-spectrum noise primarily when the pure tone was of low frequency (below 2000 cps) and contained most of the available energy in the sound field. These more prominent pure-tone exposures exceeded the criteria set forth by the US Air Force 160-3 Noise Regulation for identifying those conditions of strong pure-tone energy in noise that are believed more hazardous to hearing. However, other pronounced pure-tone conditions in this study also met these criteria even though they gave no evidence for increased hazard to hearing when their postexposure losses were compared with those of the continuous-spectrum noise. The findings were discussed with regard to the action of the acoustic reflex that has been proposed to account for the differences in the ability of pure tones and noise to cause hearing loss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - temporary hearing losses
KW - broadband noise
KW - noise field
KW - single-frequency components
KW - 1964
KW - Auditory Stimulation
KW - Auditory Thresholds
KW - Noise Effects
KW - Partially Hearing Impaired
KW - 1964
DO - 10.1121/1.1919179
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-06578-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Youtz, Adella C.
AU - Robbins, Paul R.
AU - Havens, John W.
T1 - PSYCHOLOGICAL RESISTANCE AND THE DELAYED EFFECTS OF A PERSUASIVE COMMUNICATION.
JO - Journal of Social Psychology
JF - Journal of Social Psychology
Y1 - 1964/02//
VL - 62
IS - 1
M3 - Article
SP - 45
EP - 55
SN - 00224545
AB - The present research was designed to test two hypotheses regarding the role of aroused resistance on the delayed effects of a persuasive communication. These hypotheses were (a) subjects reacting with resentment to a persuasive communication would show less delayed opinion change than subjects not reacting with resentment, and (b) subjects given an opportunity to express feelings of resentment about the communication would show greater delayed opinion change than subjects not given this opportunity. To test these hypotheses, subjects were shown a film dealing with the problem behavior of a preadolescent boy. After the film was shown, subjects were assessed on their attitude as to what was the best course of therapy for the child. One week later, subjects were read a letter from an alleged film- evaluation group of professionals (psychiatrists, psychologists, educators, etc.) which disparaged the position taken by most members of the class. All subjects were asked to fill out the attitude scale a second time, and to evaluate the communication on a simple ballot. Then one group of subjects was given the opportunity to write out their feelings about the communication in detail, while another group was not. Three weeks later, posttest attitudes regarding both the communication and the problem posed by the film were assessed. Results indicated that the first hypothesis was strongly supported, but that the second hypothesis was not. Examination of effects of the catharsis procedure raised doubts about the adequacy of its test in the present study, and suggested the need for studying the effects of catharsis under different degrees of emotional experience. The procedures of the present study produced large changes in attitude which remained essentially undiminished over the three- week delay period. Certain psychological consequences of the large opinion change were noted, and interpretations were advanced concerning the processes involved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Social Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communication -- Psychological aspects
KW - Thought & thinking
KW - Hypothesis
KW - Resentment
KW - Preteens
KW - Mental health personnel
KW - DECISION MAKING AND COMMUNICATIONS
KW - Patterns of opinion spread and opinion change
KW - Psychological factors affecting tension
N1 - Accession Number: 16520381; Youtz, Adella C. 1; Robbins, Paul R. 2; Havens, John W. 3; Affiliations: 1: Teachers College, Columbia University.; 2: Behavioral Science Section, Public Health Service, Oneonta.; 3: State University College of Education, Oneonta.; Issue Info: Feb1964, Vol. 62 Issue 1, p45; Thesaurus Term: Communication -- Psychological aspects; Thesaurus Term: Thought & thinking; Subject Term: Hypothesis; Subject Term: Resentment; Subject Term: Preteens; Subject Term: Mental health personnel; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Author-Supplied Keyword: Psychological factors affecting tension; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 1965-00240-001
AN - 1965-00240-001
AU - Bloom, Bernard L.
T1 - The code of ethics of the French Psychological Society.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1964/03//
VL - 19
IS - 3
SP - 183
EP - 185
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1965-00240-001. Partial author list: First Author & Affiliation: Bloom, Bernard L.; US Public Health Service, Denver, Colo. Release Date: 19650101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Professional Ethics; Professional Organizations; Professional Standards. Classification: General Psychology (2100). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Mar, 1964. Copyright Statement: American Psychological Association. 1964.
AB - 'The APA (1963) and the SFP (Société Française de Psychologie) codes of ethics have several major aspects in common. First, both codes deal in some detail with the issue of professional confidentiality.' 'Second, both codes recognize the social responsibility which psychologists carry… . Finally both codes recognize that obtaining and evaluating psychological data must involve the utilization of scientific method and that accurate and complete reporting of results is one of the important components of this method.' The Code of Ethics of the SFP has 7 major sections titled as follows: Area of Application, Ethics, Professional Confidentiality, Respect of Others, Science, Technical Independence, Professional Independence, The code is stated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social responsibility
KW - ethics
KW - French Psychological Society
KW - 1964
KW - Professional Ethics
KW - Professional Organizations
KW - Professional Standards
KW - 1964
DO - 10.1037/h0047602
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-00240-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Colberg, J. E.
AU - Ddray, S.
T1 - Localization by Immunofluorescence of Gamma-Globulin Allotypes in Lymph Node Cells of Homozygous and Heterozygous Rabbits.
JO - Immunology
JF - Immunology
Y1 - 1964/05//
VL - 7
IS - 3
M3 - Article
SP - 273
EP - 290
SN - 00192805
AB - The cellular production of two rabbit γ-globulin allotypic specificities, A4 and A5, determined by allelic genes was investigated by the fluorescent antibody method. The 7S γ-globulin fractions of precipitating antisera were conjugated to fluorescein isothiocyanate and to lissamine rhodamine B sulphonyl chloride. Frozen sections of lymph nodes from eighteen rabbits, A4-A4 and A5-A5 homozygotes and A4-A5 heterozygotes, were studied after exposure to the fluorescent antibody conjugates. The conjugates, each specific for antigenic determinants of 7S γ-globulin, reacted specifically with the cytoplasm of plasma cells and intrinsic cells of the germinal centres. The rabbit anti-A4 conjugate reacted only with lymph node cells of A4-A4 and A4-A5 rabbits; the rabbit anti-A5 conjugates reacted only with cells of A5-A5 and A4-A5 rabbits; the horse anti-rabbit γ-globulin conjugates reacted with cells of all three genotypes. By a variety of techniques, identical cellular localization of the two allotypes, A4 and A5, was found in the A4-A5 heterozygotes. Less than 1 per cent of the cells in any heterozygous lymph node section contained one allotype without the other. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - GAMMA globulins
KW - BLOOD proteins
KW - RABBITS
KW - LYMPH nodes
KW - IMMUNE system
N1 - Accession Number: 13274303; Colberg, J. E. 1; Ddray, S. 2; Source Information: May64, Vol. 7 Issue 3, p273; Subject: CELL proliferation; Subject: GAMMA globulins; Subject: BLOOD proteins; Subject: RABBITS; Subject: LYMPH nodes; Subject: IMMUNE system; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Russek, Henry I.
T1 - Tobacco consumption and emotional stress in the etiology of coronary heart disease.
JO - Geriatrics
JF - Geriatrics
Y1 - 1964/06//
VL - 19
IS - 6
M3 - Article
SP - 425
EP - 423
SN - 0016867X
N1 - Accession Number: 17133358; Russek, Henry I. 1; Source Information: Jun1964, Vol. 19 Issue 6, p425; Number of Pages: 9p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 3050
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1965-02192-001
AN - 1965-02192-001
AU - Ludwig, Arnold M.
AU - Lyle, William H. Jr.
T1 - Tension induction and the hyperalert trance.
JF - The Journal of Abnormal and Social Psychology
JO - The Journal of Abnormal and Social Psychology
Y1 - 1964/07//
VL - 69
IS - 1
SP - 70
EP - 76
CY - US
PB - American Psychological Association
SN - 0096-851X
N1 - Accession Number: 1965-02192-001. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Ludwig, Arnold M.; US Public Health Service Hosp., Lexington, Ky. Release Date: 20060329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consciousness States; Hypnosis. Classification: Consciousness States (2380). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1964. Copyright Statement: American Psychological Association. 1964.
AB - The traditional methods of inducing the hypnotic trance are questioned. A new induction technique was devised which radically differed from classical induction methods in its utilization of increased tension and alertness. As a result of the tension-induction methods, a "hyperalert" trance state was produced, the hypersuggestibility of which compared favorably with that produced by typical hypnotic-induction methods and was significantly greater than that produced under waking conditions. The use of these new methods may have important implications for the understanding of "natural" forms of trance as wel as for the "hypersuggestible" states supposedly produced by interrogation or brainwashing. (42 ref.) (PsycINFO Database Record (c) 2013 APA, all rights reserved)
KW - tension induction
KW - hyperalert trance
KW - hypnotic induction
KW - hypersuggestible states
KW - 1964
KW - Consciousness States
KW - Hypnosis
DO - 10.1037/h0042537
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pdh&AN=1965-02192-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - pdh
ER -
TY - JOUR
ID - 1965-02192-001
AN - 1965-02192-001
AU - Ludwig, Arnold M.
AU - Lyle, William H. Jr.
T1 - Tension induction and the hyperalert trance.
JF - The Journal of Abnormal and Social Psychology
JO - The Journal of Abnormal and Social Psychology
JA - J Abnorm Soc Psychol
Y1 - 1964/07//
VL - 69
IS - 1
SP - 70
EP - 76
CY - US
PB - American Psychological Association
SN - 0096-851X
N1 - Accession Number: 1965-02192-001. Other Journal Title: Journal of Abnormal Psychology; The Journal of Abnormal Psychology; The Journal of Abnormal Psychology and Social Psychology. Partial author list: First Author & Affiliation: Ludwig, Arnold M.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19650101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consciousness States; Hypnosis. Classification: Consciousness States (2380). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Jul, 1964. Copyright Statement: American Psychological Association. 1964.
AB - The traditional methods of inducing the hypnotic trance are questioned. A new induction technique was devised which radically differed from classical induction methods in its utilization of increased tension and alertness. As a result of the tension-induction methods, a 'hyperalert' trance state was produced, the hypersuggestibility of which compared favorably with that produced by typical hypnotic-induction methods and was significantly greater than that produced under waking conditions. The use of these new methods may have important implications for the understanding of 'natural' forms of trance as wel as for the 'hypersuggestible' states supposedly produced by interrogation or brainwashing. (42 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tension induction
KW - hyperalert trance
KW - hypnotic induction
KW - hypersuggestible states
KW - 1964
KW - Consciousness States
KW - Hypnosis
KW - 1964
DO - 10.1037/h0042537
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-02192-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-39344-005
AN - 2013-39344-005
AU - Brown, Bertram S.
AU - Cain, Harry P. II
T1 - The many meanings of 'comprehensive.'
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1964/10//
VL - 34
IS - 5
SP - 834
EP - 839
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-39344-005. Partial author list: First Author & Affiliation: Brown, Bertram S.; Community Mental Health Facilities Branch, National Institute of Mental Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Mental Health; Quality of Services. Minor Descriptor: Community Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 6. Issue Publication Date: Oct, 1964. Publication History: Accepted Date: Jun 15, 1964.
AB - 'Comprehensive,' when used to describe a community mental health center, has many meanings. They extend from reference to the range of services available and the variety of people served to reflections of the efforts and the kinds of planning needed to make a comprehensive center a reality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health
KW - comprehensive center
KW - mental health center
KW - service quality
KW - 1964
KW - Community Mental Health Services
KW - Mental Health
KW - Quality of Services
KW - Community Services
KW - 1964
DO - 10.1111/j.1939-0025.1964.tb02238.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39344-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Alderman, Michael H.
T1 -
JO - New Republic
JF - New Republic
J1 - New Republic
PY - 1964/12/26/
Y1 - 1964/12/26/
VL - 151
IS - 26
M3 - Article
SP - 17
EP - 20
SN - 00286583
AB - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964. Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare.
KW - MEDICAL care -- United States
KW - MEDICAL care for the aged
KW - SOCIAL security -- Law & legislation
KW - MEDICARE
KW - HEALTH insurance -- United States
KW - UNITED States
N1 - Accession Number: 10013939; Source Information: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 4p; ; Document Type: Article;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=mth&AN=10013939&site=ehost-live&scope=site
DP - EBSCOhost
DB - mth
ER -
TY - JOUR
T1 - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE.
AU - Surwillo, Walter W.
AU - Quilter, Reginald E.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1965/01//
VL - 1
IS - 3
SP - 272
EP - 276
SN - 00485772
N1 - Accession Number: 11044659; Author: Surwillo, Walter W.: 1 Author: Quilter, Reginald E.: 1 ; Author Affiliation: 1 National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20040119
N2 - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. ABSTRACT FROM AUTHOR
KW - *GALVANIC skin response
KW - VIGILANCE (Psychology)
KW - SIGNAL detection (Psychology)
KW - CONDITIONED response
KW - MALES
KW - BEHAVIORISM (Psychology)
KW - AGE
KW - Aging.
KW - Autonomic
KW - Skin Potential
KW - Spontaneous SPR
KW - Tarchanoff effect
KW - Vigilance
KW - Watchkeeping
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=11044659&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 2013-39668-002
AN - 2013-39668-002
AU - Ozarin, Lucy D.
AU - Brown, Bertram S.
T1 - New directions in community mental health programs.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1965/01//
VL - 35
IS - 1
SP - 10
EP - 17
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-39668-002. Partial author list: First Author & Affiliation: Ozarin, Lucy D.; Community Mental Health Facilities Branch, National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Continuum of Care; Mental Health Programs. Minor Descriptor: Professional Consultation. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 1965.
AB - New patterns of providing mental health services are emerging. A comprehensive range of readily available services close to where patients live and with continuity of care is the basis of the community mental health center concept. Implementation of the concept has shown that it results in changes in patient care and in professional practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health programs
KW - mental health services
KW - continuity of care
KW - professional practices
KW - 1965
KW - Community Mental Health Services
KW - Continuum of Care
KW - Mental Health Programs
KW - Professional Consultation
KW - 1965
DO - 10.1111/j.1939-0025.1965.tb02262.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-39668-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-01978-001
AN - 1966-01978-001
AU - Michael, Jerrold M.
T1 - Problem situations in performance counseling.
JF - Personnel
JO - Personnel
Y1 - 1965///
VL - 42
IS - 5
SP - 16
EP - 22
N1 - Accession Number: 1966-01978-001. Partial author list: First Author & Affiliation: Michael, Jerrold M.; Div. Indian Health, Public Health Service, Washington, D.C. Release Date: 19660201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Interpersonal Interaction; Management Personnel; Performance. Classification: Management & Management Training (3640). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 7. Issue Publication Date: 1965.
AB - The new focus on result-oriented appraisals takes some embarrassment out of the appraisal interview. However, it also requires greater counseling and interpersonal skills of the manager. Some typical counseling problems are discussed and suggestions are offered as to how to deal with them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - performance counseling
KW - interpersonal skills
KW - manager
KW - 1965
KW - Counseling
KW - Interpersonal Interaction
KW - Management Personnel
KW - Performance
KW - 1965
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-01978-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1965-15107-001
AN - 1965-15107-001
AU - Metz, A. Stafford
T1 - A comparison of the use of the sound recording and the written transcript in the coding of verbal interaction.
JF - The Journal of Social Psychology
JO - The Journal of Social Psychology
JA - J Soc Psychol
Y1 - 1965///
VL - 65
IS - 2
SP - 325
EP - 335
CY - US
PB - Heldref Publications
SN - 0022-4545
SN - 1940-1183
N1 - Accession Number: 1965-15107-001. Partial author list: First Author & Affiliation: Metz, A. Stafford; U. S. Public Health Service, Washington, D. C. Other Publishers: Taylor & Francis. Release Date: 19650601. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Group Counseling; Spouses; Verbal Communication. Minor Descriptor: Auditory Stimulation. Classification: Group & Family Therapy (3313). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: 1965.
AB - Verbal behavior of married couples in group counseling was coded using the sound recording plus the typed transcript and using the transcript alone. The coding schema used was the Leary set of interpersonal categories. To a large extent the results for the 2 conditions were similar although for several categories frequencies were too small for reliable comparison. The data suggest, however, that, for statements comprised of both hostility and dominance, hostility is more readily distinguishable with the sound recording than with the written transcript alone. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sound recording
KW - written transcript
KW - verbal interaction
KW - married couples
KW - group counseling
KW - 1965
KW - Group Counseling
KW - Spouses
KW - Verbal Communication
KW - Auditory Stimulation
KW - 1965
DO - 10.1080/00224545.1965.9919610
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-15107-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-01627-001
AN - 1966-01627-001
AU - Brown, Daniel G.
T1 - Some current issues in psychotherapy.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1965///
VL - 17
IS - 2
SP - 651
EP - 658
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1966-01627-001. PMID: 5319431 Partial author list: First Author & Affiliation: Brown, Daniel G.; US Public Health Service, Mental Health Service Region IV Atlanta, Ga. Other Publishers: Sage Publications. Release Date: 19660201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Psychotherapeutic Processes; Psychotherapy. Minor Descriptor: Neurosis; Psychiatric Symptoms. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Page Count: 8. Issue Publication Date: 1965.
AB - Some of the basic issues in psychotherapy today include: the nature of neurotic symptoms, the role of insight, emphasis on reconstructing the past vs. readjusting to the present, the relationship between therapist and patient, activeness-passiveness of the therapist, distinctive techniques used, length of psychotherapy, total number of sessions and duration of a session, types of patients in relation to therapeutic approaches, permanence of improvement, and principal goal or purpose of psychotherapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotherapy
KW - neurotic symptoms
KW - therapist patient relationship
KW - 1965
KW - Psychotherapeutic Processes
KW - Psychotherapy
KW - Neurosis
KW - Psychiatric Symptoms
KW - 1965
DO - 10.2466/pr0.1965.17.2.651
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-01627-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Palmer, C. Mervin
T1 - Phytoplankton Periodicity in a Newfoundland Pond.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1965/03//
VL - 1
IS - 1
M3 - Article
SP - 39
EP - 40
PB - Wiley-Blackwell
SN - 00223646
AB - In 1954 a boiler-scale problem developed in a power plant at Argentia, Newfoundland. It was suggested that the algae in the water supply coming from Clarks pond might be partly responsible. After a visit to Argentia to determine the effectiveness of a diatomite filter which had been suggested to remove the algae from the water supply, weekly samples were analyzed microscopically for over 4 years because of early evidence of a periodicity among the dominant algae. Clarks pond is approximately 2800 feet long and 1200 feet wide at its greater dimensions and has a maximum capacity of almost 100 million gallons. The water is relatively clean, with a turbidity of 10 mg/l and is very corrosive being O[sub2]-saturated. The outstanding feature of the phytoplankton in Clarks pond is the reappearance each year of an essentially similar succession of the algal pulses.
KW - Phytoplankton
KW - Ponds
KW - Algae
KW - Power plants
KW - Argentia (N.L.)
KW - Newfoundland & Labrador
KW - Canada
N1 - Accession Number: 11628494; Palmer, C. Mervin 1; Affiliations: 1: U. S. Department of Health, Education, and Welf- are, Public Health Service. Robert A. Taft Sanitary Engineering Center, Cincinnati, Ohio.; Issue Info: Mar1965, Vol. 1 Issue 1, p39; Thesaurus Term: Phytoplankton; Thesaurus Term: Ponds; Thesaurus Term: Algae; Thesaurus Term: Power plants; Subject: Argentia (N.L.); Subject: Newfoundland & Labrador; Subject: Canada; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112519 Other Aquaculture; NAICS/Industry Codes: 237130 Power and Communication Line and Related Structures Construction; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11628494&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1965-10233-001
AN - 1965-10233-001
AU - Haertzen, Charles A.
AU - Miner, Edward J.
T1 - Effect of alcohol on the Guilford-Zimmerman scales of extraversion.
JF - Journal of Personality and Social Psychology
JO - Journal of Personality and Social Psychology
JA - J Pers Soc Psychol
Y1 - 1965/04//
VL - 1
IS - 4
SP - 333
EP - 336
CY - US
PB - American Psychological Association
SN - 0022-3514
SN - 1939-1315
N1 - Accession Number: 1965-10233-001. Partial author list: First Author & Affiliation: Haertzen, Charles A.; US Public Health Service Hosp., Lexington, Ky. Release Date: 19650101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcoholism; Extraversion; Rating Scales. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Apr, 1965. Copyright Statement: American Psychological Association. 1965.
AB - According to Eysenck's theory depressant drugs should increase extraversion. 80 postnarcotic addicts were given the Guilford-Zimmerman Temperament Survey under no-drug and alcohol (3.0 cc/kg of 30% alcohol) conditions. No significant differences were found on scales that measure extraversion-introversion. Lack of significance for the Rhathymia (R) scale was associated with lack of significance for items. The R scale was not significantly correlated with the Addiction Research Center Inventory scales for alcohol or amphetamine. Therefore, no direct confirmation of Eysenck's theory was found. However, it was suggested that some extraversion (R) items as well as items from other scales would be sensitive to effects of drugs if they were rewritten so as to suggest reactivity or current psychological status. (20 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol
KW - Guilford-Zimmerman scales of extraversion
KW - 1965
KW - Alcoholism
KW - Extraversion
KW - Rating Scales
KW - 1965
DO - 10.1037/h0021907
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1965-10233-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - RPRT
AU - Ehrlich, Howard J.
AU - Bauer, Mary Lou
T1 - NEWSPAPER CITATION AND REPUTATION FOR COMMUNITY LEADERSHIP.
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1965/06//
VL - 30
IS - 3
M3 - Report
SP - 411
EP - 415
SN - 00031224
AB - Research based on Prince Georges County, Maryland, adjacent to Washington, D.C. Reputations for community leadership were assessed by a survey conducted by the National Opinion Research Center. A study of three newspapers shows that political office-holders are overrepresented in newspaper citation. The frequency of citation of leaders is stable in each of the newspapers, and shows a positive and significant correlation with the survey votes in this county-wide sample. 3 tables, 5 notes.
KW - COMMUNITY leadership
KW - REPUTATION (Sociology)
KW - SURVEYS
KW - NEWSPAPERS
KW - UNITED States. National Opinion Research Center
KW - PUBLIC opinion
KW - UNITED States
KW - PRINCE George's County (Md.)
N1 - Accession Number: 12768433; Ehrlich, Howard J. 1; Bauer, Mary Lou 2; Affiliations: 1 : State University of Iowa; 2 : U.S. Public Health Service; Source Info: Jun65, Vol. 30 Issue 3, p411; Historical Period: 1962 to 1963; Subject Term: COMMUNITY leadership; Subject Term: REPUTATION (Sociology); Subject Term: SURVEYS; Subject Term: NEWSPAPERS; Subject Term: UNITED States. National Opinion Research Center; Subject Term: PUBLIC opinion; Subject: UNITED States; Subject: PRINCE George's County (Md.); Number of Pages: 5p; Document Type: Report
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ahl&AN=12768433&site=ehost-live&scope=site
DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Linn, Erwin L.
T1 - Lives in Distress: The Paths of the Elderly to the Psychiatric Ward (Book).
JO - American Sociological Review
JF - American Sociological Review
Y1 - 1965/08//
VL - 30
IS - 4
M3 - Book Review
SP - 617
EP - 618
SN - 00031224
AB - Reviews the book, "Lives in Distress: The Paths of the Elderly to the Psychiatric Ward," by Marjorie Fiske Lowenthal.
KW - MENTALLY ill
KW - NONFICTION
KW - LOWENTHAL, Marjorie Fiske
KW - LIVES in Distress: The Paths of the Elderly to the Psychiatric Ward (Book)
N1 - Accession Number: 12801106; Linn, Erwin L. 1; Affiliations: 1: U.S. Public Health Service; Issue Info: Aug65, Vol. 30 Issue 4, p617; Subject Term: MENTALLY ill; Subject Term: NONFICTION; Reviews & Products: LIVES in Distress: The Paths of the Elderly to the Psychiatric Ward (Book); People: LOWENTHAL, Marjorie Fiske; Number of Pages: 2p; Document Type: Book Review
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12801106&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Stevenson, Eugene
T1 - FDA and geriatrics.
JO - Geriatrics
JF - Geriatrics
Y1 - 1965/08//
VL - 20
IS - 8
M3 - Article
SP - 691
EP - 692
SN - 0016867X
N1 - Accession Number: 17091436; Stevenson, Eugene 1; Source Information: Aug1965, Vol. 20 Issue 8, p691; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 687
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17091436&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Meyers, Earl L
T1 - New drug information requirements
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1965/11//
VL - 5
IS - 4
M3 - Article
SP - 251
EP - 258
SN - 00219576
AB - The meanings and implication of the rules and regulations in the federal food, drug, and cosmetic act are reviewed and discussed for the food and drug administration and for sponsors of foods, drugs, and costemics. Drug information requirements are stressed in particular.
N1 - Accession Number: ISTA0100391; Meyers, Earl L 1; Affiliations: 1 : Food And Drug Administration; Source Info: November 1965, Vol. 5 Issue 4, p251; Note: Update Code: 0100; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0100391&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 1967-16021-001
AN - 1967-16021-001
AU - Horn, Daniel
AU - Waingrow, Selwyn
T1 - Some dimensions of a model for smoking behavior change.
JF - American Journal of Public Health & the Nation's Health
JO - American Journal of Public Health & the Nation's Health
Y1 - 1966///
VL - 56
IS - 12 SUPPL.
SP - 21
EP - 26
N1 - Accession Number: 1967-16021-001. Partial author list: First Author & Affiliation: Horn, Daniel; U.s. Public Health Service, Washington D.C. Release Date: 19670101. Correction Date: 20170216. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior; Simulation; Social Change; Tobacco Smoking. Classification: Psychometrics & Statistics & Methodology (2200). Population: Human (10). Page Count: 6. Issue Publication Date: 1966.
AB - CONSIDERS 4 DIMENSIONS OF A MODEL FOR SMOKING BEHAVIOR CHANGE: MOTIVATION FOR CHANGE, PERCEPTION OF THE THREAT, DEVELOPMENT AND USE OF ALTERNATIVE PSYCHOLOGICAL MECHANISMS, AND FACTORS FACILITATING OR INHIBITING CONTINUING REINFORCEMENT. HEALTH FACTORS ARE CONSIDERED PRIMARY AMONG THE REASONS PEOPLE CONSIDER GIVING UP SMOKING. SUCCESS IN SMOKING BEHAVIOR CHANGE IS SEEN PARTIALLY AS A FUNCTION OF THE ADEQUACY OF THE METHODS USED IN GIVING UP SMOKING TO SATISFY THE PSYCHOLOGICAL NEEDS WHICH WERE ORIGINALLY SATISFIED BY SMOKING. IT IS ALSO SEEN AS A FUNCTION OF THE PRESENCE OF FACILITATORS TO ENCOURAGE SUCH ACTION AND PROVIDE REINFORCEMENT. SOCIAL FORCES, INTERPERSONAL INFLUENCES, MASS MEDIA, THE BEHAVIOR AND ATTITUDES OF KEY GROUPS, AND THE GENERAL LEVEL OF ACCEPTABILITY OF THE BEHAVIOR ARE AMONG THE FACTORS CONSIDERED AS FACILITATORS OR INHIBITORS. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - SMOKING BEHAVIOR CHANGE
KW - 1966
KW - Behavior
KW - Simulation
KW - Social Change
KW - Tobacco Smoking
KW - 1966
DO - 10.2105/AJPH.56.12_Suppl.21
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-16021-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-07916-001
AN - 1966-07916-001
AU - Nickols, John
T1 - Self-image ratings of normal and disturbed subjects.
JF - Journal of Health & Human Behavior
JO - Journal of Health & Human Behavior
Y1 - 1966///
VL - 7
IS - 1
SP - 28
EP - 36
CY - US
PB - American Sociological Assn
N1 - Accession Number: 1966-07916-001. Other Journal Title: Journal of Health and Social Behavior. Partial author list: First Author & Affiliation: Nickols, John; U.S. Public Health Service Outpatient Clinic, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19660701. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Individuality; Self-Concept. Minor Descriptor: Rating. Classification: Personality Traits & Processes (3120). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: 1966.
AB - Since man tends to seek an awareness of his own significance through his interaction with others, he is challenged inadvertently to achieve a sense of self-enhancement or individuality without resorting to excessive self-deceit, self-exaltation or self-depreciation. It seems consistent with this perspective that 75 non-psychiatric adults obtained higher mean scores on the self-administered Self-Image Rating Scale than 40 schizophrenics, whose ratings suggested the assimilation of self-images denoting real or imagined social isolation. High scores could be used to suggest attitudes about the self or others which appear well regulated by subjective experiences of oneself as a social being. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self image rating
KW - normal subjects
KW - disturbed subjects
KW - self enhancement
KW - individuality
KW - 1966
KW - Individuality
KW - Self-Concept
KW - Rating
KW - 1966
DO - 10.2307/2948676
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-07916-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-07053-001
AN - 1966-07053-001
AU - Newman, Sidney H.
AU - Howell, Margaret A.
T1 - Do objective professional examinations involve reasoning?
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1966///
VL - 18
IS - 1
SP - 123
EP - 129
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1966-07053-001. PMID: 5908471 Partial author list: First Author & Affiliation: Newman, Sidney H.; U.S. Public Health Service, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19660601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Medical Psychology; Professional Examinations; Reasoning. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 7. Issue Publication Date: 1966.
AB - An objective professional examination in medicine and 3 relatively 'pure' tests of reasoning were administered to a key development group of 88 medical interns and a cross-validation group of 83 interns. Results suggest that professional examination items involving reasoning can be identified by a physician or by item-analysis against reasoning tests. Judgmentally identified items correlated .35-.49 with general and deductive reasoning; items identified by item-analysis correlated on cross-validation, .37-.46 with these reasoning factors. (Spearman-Brown estimates were in the .50-.70 range.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - professional examinations
KW - reasoning
KW - medicine
KW - 1966
KW - Medical Psychology
KW - Professional Examinations
KW - Reasoning
KW - 1966
DO - 10.2466/pr0.1966.18.1.123
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-07053-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-11610-001
AN - 1966-11610-001
AU - Newman, Sidney H.
T1 - Psychologist, heal thyself.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1966///
VL - 19
IS - 1
SP - 175
EP - 179
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1966-11610-001. PMID: 5942080 Partial author list: First Author & Affiliation: Newman, Sidney H.; U.S. Public Health Service, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19661101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Professional Competence; Professional Examinations; Psychologists. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 5. Issue Publication Date: 1966.
AB - The American Board of Examiners in Professional Psychology should develop the best possible measures of professional competence at the diplomate level. This means a change from exclusive use of essay and oral examinations to greater utilization of objective professional examinations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - professional competence
KW - psychologists
KW - professional examinations
KW - 1966
KW - Professional Competence
KW - Professional Examinations
KW - Psychologists
KW - 1966
DO - 10.2466/pr0.1966.19.1.175
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-11610-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-06129-001
AN - 1967-06129-001
AU - Rosner, Bennett L.
T1 - The use of valid psychological complaints to screen, minimize or deny serious somatic illness.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1966///
VL - 143
IS - 3
SP - 234
EP - 238
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 1967-06129-001. PMID: 5959547 Partial author list: First Author & Affiliation: Rosner, Bennett L.; U.s. Public Health Service, Terre Haute, Ind. Release Date: 19670101. Correction Date: 20170227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disorders; Somatoform Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 5. Issue Publication Date: 1966.
AB - WHILE PREVIOUSLY REPORTED CASES OF DENIAL OF ILLNESS HAVE LARGELY PRESENTED ORGANIC BRAIN SYNDROME OR PSYCHOSOMATIC EXPLANATIONS, 4 CASES ARE DESCRIBED 'WITH COMPLAINTS OF A PURELY PSYCHOLOGICAL NATURE . . . . THE PSYCHOLOGICAL SYMPTOMS ARE USED INSTEAD OF OVERTLY ADMITTING TO PHYSICAL ILLNESS, AS CONTRASTED WITH PSYCHOSOMATIC EXPLANATIONS FOR PHYSICAL SYMPTOMS.' (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - PSYCHOLOGICAL COMPLAINT CONCEALMENT OF PHYSICAL ILLNESS
KW - 1966
KW - Disorders
KW - Somatoform Disorders
KW - 1966
DO - 10.1097/00005053-196609000-00005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-06129-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-02782-001
AN - 1967-02782-001
AU - Linn, Erwin L.
T1 - Social meanings of dental appearance.
JF - Journal of Health & Human Behavior
JO - Journal of Health & Human Behavior
Y1 - 1966///
VL - 7
IS - 4
SP - 289
EP - 295
CY - US
PB - American Sociological Assn
N1 - Accession Number: 1967-02782-001. PMID: 5976220 Other Journal Title: Journal of Health and Social Behavior. Partial author list: First Author & Affiliation: Linn, Erwin L.; U.s. Public Health Service, 14th Ave. + Lake St., San Francisco, Calif. Other Publishers: Sage Publications. Release Date: 19670101. Correction Date: 20170227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Mouth (Anatomy). Classification: Social Processes & Social Issues (2900). Population: Human (10). Page Count: 7. Issue Publication Date: 1966.
AB - IN A NATION-WIDE SURVEY ABOUT DENTAL CARE AND ATTITUDES, QUESTIONS WERE ASKED ABOUT THE IMPORTANCE OF DENTAL APPEARANCE. AT THE END OF THE INTERVIEWS, INTERVIEWERS RATED VISIBLY MISSING OR STAINED TEETH. THEY JUDGED ALSO IF ANY SELF-CONSCIOUS BEHAVIOR ABOUT DENTAL APPEARANCE HAD OCCURRED DURING THE INTERVIEW. FINDINGS INDICATE HIGH PUBLIC AWARENESS THAT DENTAL APPEARANCE MAY BE IMPORTANT, BUT KINDS OF SOCIAL SITUATIONS AND CHARACTERISTICS OF PARTICIPANTS WERE OBVIOUSLY QUALIFICATIONS OF ATTITUDES. ATTITUDES WERE NOT QUALIFIED BY SS' SOCIAL BACKGROUND OR STATUS. THEIR DENTAL APPEARANCE AND WHETHER OR NOT THEY WERE SELF-CONSCIOUS DURING THE INTERVIEW WERE SO QUALIFIED. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - DENTAL APPEARANCE/TOWARD
KW - 1966
KW - Attitudes
KW - Mouth (Anatomy)
KW - 1966
DO - 10.2307/2948777
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-02782-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-05681-001
AN - 1966-05681-001
AU - Weech, Alexander A. Jr.
T1 - The narcotic addict and 'the street.'
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1966///
VL - 14
IS - 3
SP - 299
EP - 306
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1966-05681-001. Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Weech, Alexander A. Jr.; U.S. Public Health Service Hosp., Lexington, Ky. Release Date: 19660501. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Drug Rehabilitation; Major Depression; Narcotic Drugs; Psychotherapy. Classification: Substance Abuse & Addiction (3233); Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: 1966.
AB - Examines the psychological significance of 'the street,' a phrase often employed by the narcotic addict. The data utilized spring from clinical impressions during group and individual psychotherapeutic sessions with male addict patients with severe personality disorders. Evidence is presented which suggests that the addict has in some ways substituted the street for his home, and that its appeal lies in its provision of a setting which permits reinforcement of a number of personality patterns. These include the denial of depression by maintaining a range of activities which would be ordinarily curtailed by social and individual values, the reduction of the risk of narcissistic injury by surrounding oneself with friends of a similar orientation to life, and direct gratification of dependent, infantile yearnings. It appears also that the impoverished personality is partly replenished by the negative identity which the street offers. Effective treatment of the hospitalized addict is often impeded by the overwhelming desire of the patient to return to the street. It is suggested, therefore, that as part of his treatment the addict be helped toward insight into some of the emotional meanings of the street. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - narcotic addicts
KW - psychotherapeutic sessions
KW - depression
KW - 1966
KW - Drug Addiction
KW - Drug Rehabilitation
KW - Major Depression
KW - Narcotic Drugs
KW - Psychotherapy
KW - 1966
DO - 10.1001/archpsyc.1966.01730090075012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-05681-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-05725-001
AN - 1966-05725-001
AU - Glaser, Frederick B.
T1 - Inhalation psychosis and related states.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1966///
VL - 14
IS - 3
SP - 315
EP - 321
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1966-05725-001. Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Glaser, Frederick B.; U. S. Public Health Service Hosp., Lexington, Ky. Release Date: 19660501. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Inhalant Abuse; Psychosis; Solvents. Minor Descriptor: Intelligence. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Page Count: 7. Issue Publication Date: 1966.
AB - The practice of deliberate inhalation of a wide variety of substances containing organic solvents, especially gasoline and model airplane glue, has of late been widely reported. A number of techniques are employed in achieving an acute intoxication from these substances, which appears to be a toxic delirium. The impulse to engage in such practices may be very strong and may result in chronic usage, which resembles in some respects addiction to narcotics and to alcohol. Despite some dispute about the direct toxic effects of these substances on various organs, a number of deaths have been associated with the practice. Most cases reported are in their early teens, though the spread is considerable. The intoxicant used may bear some relationship to age-determined availability. There is a high preponderance of males, and broken homes and minority group status may also be seen. In some cases diminished intelligence is present. Unusual accessory utilization of tobacco and alcohol, but not of narcotics, is reported. The practice appears to be conductive to the performance of antisocial acts as well as being a favored outlet of those already antisocially inclined. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - inhalation psychosis
KW - organic solvents
KW - intelligence
KW - 1966
KW - Inhalant Abuse
KW - Psychosis
KW - Solvents
KW - Intelligence
KW - 1966
DO - 10.1001/archpsyc.1966.01730090091014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-05725-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-00314-001
AN - 1967-00314-001
AU - Hershberg, Philip I.
T1 - Sensitivity of populations of visual cortical cells to variable period stimulation.
JF - Nature
JO - Nature
JA - Nature
Y1 - 1966///
VL - 212
IS - 5059
SP - 323
EP - 324
CY - United Kingdom
PB - Nature Publishing Group
SN - 0028-0836
SN - 1476-4687
N1 - Accession Number: 1967-00314-001. PMID: 5970139 Partial author list: First Author & Affiliation: Hershberg, Philip I.; U.s. Public Health Service Hosp., Brighton, Mass. Release Date: 19670101. Correction Date: 20170227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Image; Evoked Potentials; Neurophysiology; Visual Cortex. Minor Descriptor: Cats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 2. Issue Publication Date: 1966.
AB - AN INVESTIGATION DESIGNED TO DETERMINE (1) HOW MANY FRAMES THE MAMMALIAN VISUAL SYSTEM CAN PROCESS IN 1 SEC.; (2) IF THE RATE IS FINITE, WHETHER IT IS FIXED OR VARIABLE; (3) IF FIXED, THE RATE; AND (4) IF VARIABLE, THE PROCESSING TIME FOR EACH FRAME. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - IMAGE PROCESSING & VISUAL FRAME THEORY
KW - OPTIC NERVE STIMULATION & CORTICAL EVOKED RESPONSES
KW - CAT
KW - 1966
KW - Body Image
KW - Evoked Potentials
KW - Neurophysiology
KW - Visual Cortex
KW - Cats
KW - 1966
DO - 10.1038/212323a0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-00314-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-08259-001
AN - 1966-08259-001
AU - Haertzen, Charles A.
AU - Horine, Ilze
T1 - Non-comparability of the 1950 and 1956 Forms A of Cattell's Sixteen Personality Factor Questionnaire.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1966///
VL - 18
IS - 2
SP - 342
EP - 342
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1966-08259-001. Partial author list: First Author & Affiliation: Haertzen, Charles A.; U.S. Public Health Service Hosp., Lexington, Ky. Other Publishers: Sage Publications. Release Date: 19660801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: No terms assigned. Classification: Psychometrics & Statistics & Methodology (2200). Page Count: 1. Issue Publication Date: 1966.
KW - VALIDITY
KW - CATTELL'S 16 PF QUESTIONNAIRE
KW - NONCOMPARABILITY OF 1950 & 1956 FORMS A
KW - TESTING
KW - 1966
KW - No terms assigned
KW - 1966
DO - 10.2466/pr0.1966.18.2.342
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-08259-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-08885-001
AN - 1966-08885-001
AU - Bauer, Mary L.
AU - Ehrlich, Howard J.
T1 - Sibling sex distribution and psychiatric status.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1966///
VL - 18
IS - 2
SP - 365
EP - 366
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1966-08885-001. Partial author list: First Author & Affiliation: Bauer, Mary L.; U.S. Public Health Service, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19660801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Sex Differences; Mental Disorders; Siblings. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Methodology: Empirical Study. Page Count: 2. Issue Publication Date: 1966.
AB - High psychiatric impairment was found to be differentially distributed among sibship types by sex, with females from opposite sex sibships and males from same sex sibships being most impaired. For both sexes, the mixed sex sibships had the most negative outcome at the conclusion of therapy, although differences were small. Control analyses indicated that sex is not independently related to any given measure of psychiatric impairment or outcome, nor is there any sex bias in the direction of high or low impairment when sibship type is controlled. Thus, the differences in psychiatric status observed in these data appear to be associated with the combination of sex and sibling sex distribution. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sibling sex distribution
KW - psychiatric impairment
KW - 1966
KW - Human Sex Differences
KW - Mental Disorders
KW - Siblings
KW - 1966
DO - 10.2466/pr0.1966.18.2.365
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-08885-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-06527-001
AN - 1966-06527-001
AU - Tippett, Jean S.
AU - Silber, Earle
T1 - Autonomy of self-esteem: An experimental approach.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1966///
VL - 14
IS - 4
SP - 372
EP - 385
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1966-06527-001. PMID: 5910889 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Tippett, Jean S.; Public Health Service, Bethesda, Md. Release Date: 19660601. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Independence (Personality); Personality Development; Self-Esteem. Minor Descriptor: Autonomy. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. Page Count: 14. Issue Publication Date: 1966.
AB - The autonomy of self-esteem in late adolescent Ss with respect to influence by an external, authoritative source was explored through an experimental study. Following a series of procedures which included a Self-Image Questionnaire, the experimental group was presented with a fictitious 'research staff evaluation' in which the Ss' own self-ratings were consistently altered in a less favorable but plausible direction on certain items of the questionnaire. When retested, the experimental group showed significant changes toward lower self-esteem on the altered dimensions and also showed a greater trend toward lower self-esteem on the unaltered dimensions in contrast to the control group. Interview data indicated that Ss experienced the experimental situation as it was intended and different subjective patterns of response to the experimental procedure were described. The findings support a conception of autonomy as a particular pattern of response to influence rather than the capacity to resist influence alone. The autonomous pattern involves both the capacity to be open to new experience as well as the ability to be discriminating with respect to it. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self esteem
KW - adolescent development
KW - autonomy
KW - 1966
KW - Adolescent Development
KW - Independence (Personality)
KW - Personality Development
KW - Self-Esteem
KW - Autonomy
KW - 1966
DO - 10.1001/archpsyc.1966.01730100036006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-06527-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-07414-001
AN - 1966-07414-001
AU - Essig, Carl F.
AU - Flanary, H. G.
T1 - The importance of the convulsion in occurrence and rate of development of electroconvulsive threshold elevation.
JF - Experimental Neurology
JO - Experimental Neurology
JA - Exp Neurol
Y1 - 1966///
VL - 14
IS - 4
SP - 448
EP - 452
CY - Netherlands
PB - Elsevier Science
SN - 0014-4886
N1 - Accession Number: 1966-07414-001. PMID: 4378199 Partial author list: First Author & Affiliation: Essig, Carl F.; Addiction Res. Cent., Public Health Service, Lexington, Ky. Release Date: 19660701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Electroconvulsive Shock; Seizures; Thresholds. Classification: Electrophysiology (2530); Neurological Disorders & Brain Damage (3297). Population: Human (10). Page Count: 5. Issue Publication Date: 1966.
AB - It was concluded that the tolerance-like response to electrically induced convulsions depends on mechanisms related to the convulsive process itself more than the stimulus of origin. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - convulsions
KW - electroconvulsive threshold elevation
KW - 1966
KW - Electroconvulsive Shock
KW - Seizures
KW - Thresholds
KW - 1966
DO - 10.1016/0014-4886(66)90129-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-07414-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-03650-001
AN - 1967-03650-001
AU - Newman, Sidney H.
T1 - Organized psychology and the crisis in testing.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1966///
VL - 19
IS - 3, PT. 1
SP - 695
EP - 701
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1967-03650-001. Partial author list: First Author & Affiliation: Newman, Sidney H.; U.s. Public Health Service, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19670101. Correction Date: 20170227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Measurement; Organizations; Testing. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 7. Issue Publication Date: 1966.
AB - PSYCHOLOGICAL TESTING AND MANY OTHER AREAS OF PSYCHOLOGY HAVE SUFFERED MARKEDLY FROM A LACK OF UNDERSTANDING BY THE AMERICAN PUBLIC. THE PUBLIC HAS LOST MANY BENEFITS TO BE DERIVED FROM PSYCHOLOGY. A DEPARTMENT OF PUBLIC AFFAIRS SHOULD BE ESTABLISHED IN THE APA TO INFORM AND EDUCATE THE PUBLIC CONCERNING THE PROBLEMS AND BENEFITS OF TESTING AND TO MAKE THE THEORIES, METHODS, AND FINDINGS OF PSYCHOLOGISTS UNDERSTOOD BY, AND USEFUL TO, AS MANY PEOPLE AS POSSIBLE. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - PUBLIC OPINION TOWARD PSYCHOLOGICAL TESTING
KW - ROLE OF APA
KW - 1966
KW - Attitudes
KW - Measurement
KW - Organizations
KW - Testing
KW - 1966
DO - 10.2466/pr0.1966.19.3.695
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-03650-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1966-10722-001
AN - 1966-10722-001
AU - Lee, Douglas H.
AU - Henschel, Austin
T1 - Effects of physiological and clinical factors on response to heat.
JF - Annals of the New York Academy of Sciences
JO - Annals of the New York Academy of Sciences
JA - Ann N Y Acad Sci
Y1 - 1966///
VL - 134
IS - 2
SP - 743
EP - 749
CY - US
PB - New York Academy of Sciences
SN - 0077-8923
N1 - Accession Number: 1966-10722-001. Partial author list: First Author & Affiliation: Lee, Douglas H.; Div. of Occupational Health, Public Health Service, Cincinnati, O. Release Date: 19661001. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Heat Effects; Physiology. Classification: Physiological Processes (2540). Population: Human (10); Male (30). Page Count: 7. Issue Publication Date: 1966.
AB - Proposes a method for predicting the responses of men to hot environments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hot environments
KW - physiological factors
KW - clinical factors
KW - 1966
KW - Heat Effects
KW - Physiology
KW - 1966
DO - 10.1111/j.1749-6632.1966.tb43059.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1966-10722-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Levitt, Donald G
T1 - Drug monitoring system
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1966/02//
VL - 6
IS - 1
M3 - Article
SP - 34
EP - 37
SN - 00219576
AB - A description is given of the system used by the bureau of medicine of the u. S. Food and drug administration for collecting, evaluating, analyzing, and communicating adverse drug reaction data. The collection, already very large, grows by several thousand documents per month.
N1 - Accession Number: ISTA0100292; Levitt, Donald G 1; Affiliations: 1 : U.s. Food And Drug Administration; Source Info: February 1966, Vol. 6 Issue 1, p34; Note: Update Code: 0100; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Ochota, Leszek
T1 -
JO - New Republic
JF - New Republic
J1 - New Republic
PY - 1966/05/14/
Y1 - 1966/05/14/
VL - 154
IS - 20
M3 - Article
SP - 21
EP - 22
SN - 00286583
AB - Explores the clinical evidence for the mechanism of action of the hallucinogenic drug lysergic acid diethylamide or LSD. Stages of action of LSD in a human being; Implications of the psychotic reactions to LSD; Clinical indications for the administration of LSD; Adverse reactions from hallucinogens; Dangers of the self-administration of LSD.
KW - LSD (Drug)
KW - HALLUCINOGENIC drugs
KW - PSYCHIATRIC drugs
KW - PSYCHOSES
KW - CLINICAL indications
N1 - Accession Number: 10508546; Source Information: 5/14/66, Vol. 154 Issue 20, p21; Subject Term: LSD (Drug); Subject Term: HALLUCINOGENIC drugs; Subject Term: PSYCHIATRIC drugs; Subject Term: PSYCHOSES; Subject Term: CLINICAL indications; Subject Term: ; Number of Pages: 2p; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Cashman, John M.
T1 - How to make the most of Medicare for the patient.
JO - Geriatrics
JF - Geriatrics
Y1 - 1966/07//
VL - 21
IS - 7
M3 - Article
SP - 146
EP - 148
SN - 0016867X
N1 - Accession Number: 17340089; Cashman, John M. 1; Source Information: Jul1966, Vol. 21 Issue 7, p146; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1331
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Myers, J.
AU - Frei, J. V.
AU - Cohen, J. J.
AU - Rose, B.
AU - Richter, M.
T1 - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions.
JO - Immunology
JF - Immunology
Y1 - 1966/08//
VL - 11
IS - 2
M3 - Article
SP - 155
EP - 162
SN - 00192805
AB - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BASAL lamina
KW - IMMUNE serums
KW - TISSUES
KW - SODIUM hydroxide
KW - IMMUNOGLOBULINS
KW - RABBITS as laboratory animals
KW - ANTIGENS
N1 - Accession Number: 13284172; Myers, J. 1; Frei, J. V. 2; Cohen, J. J. 3,4; Rose, B. 3,4; Richter, M. 5; Source Information: Aug66, Vol. 11 Issue 2, p155; Subject: BASAL lamina; Subject: IMMUNE serums; Subject: TISSUES; Subject: SODIUM hydroxide; Subject: IMMUNOGLOBULINS; Subject: RABBITS as laboratory animals; Subject: ANTIGENS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Mergenhagen, S. E.
AU - Notkins, A. L.
AU - Evans, R. T.
T1 - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies.
JO - Immunology
JF - Immunology
Y1 - 1966/09//
VL - 11
IS - 3
M3 - Article
SP - 223
EP - 228
SN - 00192805
AB - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies.
KW - GAMMA globulins
KW - IMMUNOGLOBULINS
KW - AGGLUTINATION of blood
KW - IMMUNE serums
KW - ERYTHROCYTES
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 14578238; Mergenhagen, S. E.; Notkins, A. L. 1; Evans, R. T. 1; Source Information: Sep66, Vol. 11 Issue 3, p223; Subject: GAMMA globulins; Subject: IMMUNOGLOBULINS; Subject: AGGLUTINATION of blood; Subject: IMMUNE serums; Subject: ERYTHROCYTES; Subject: ANTIGEN-antibody reactions; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Lee, Douglas H. K.
T1 - The Role of Attitude in Response to Environmental Stress.
JO - Journal of Social Issues
JF - Journal of Social Issues
Y1 - 1966/10//
VL - 22
IS - 4
M3 - Article
SP - 83
EP - 91
SN - 00224537
AB - The article examines the role of attitude in response to environmental stress. Attitude results from a judgmental process in which the features of a real or hypothetical environmental situation are matched against some standard of acceptability. Attitude may be affected by factors operating on the situational information supplied to the site of judgment, on the standard of reference, or on the judgmental process itself. Attitude towards environmental stress is definable only over a small time interval, and should be considered in terms of all the circumstances prevailing over that interval. It varies in first order fashion, fairly quickly, over a fairly wide range in accordance with a wide variety of physiological and psychological circumstances. Its median value varies over longer periods of time, in second order fashion, in accordance with experience. But, whatever its status at the moment, it can influence both behavioral and physiological responses to environmental stimuli, and markedly affect the significance of a given environmental situation for the exposed individual.
KW - ATTITUDE (Psychology)
KW - BEHAVIOR
KW - ENVIRONMENTAL engineering
KW - JUDGMENT (Psychology)
KW - EMOTIONS (Psychology)
KW - AVERSIVE stimuli
KW - DECISION MAKING AND COMMUNICATIONS
KW - Patterns of opinion spread and opinion change
N1 - Accession Number: 16461178; Lee, Douglas H. K. 1; Affiliations: 1 : Department of Health Education and Welfare, Public Health Service, National Environmental Health Science Center.; Source Info: Oct1966, Vol. 22 Issue 4, p83; Subject Term: ATTITUDE (Psychology); Subject Term: BEHAVIOR; Subject Term: ENVIRONMENTAL engineering; Subject Term: JUDGMENT (Psychology); Subject Term: EMOTIONS (Psychology); Subject Term: AVERSIVE stimuli; Author-Supplied Keyword: DECISION MAKING AND COMMUNICATIONS; Author-Supplied Keyword: Patterns of opinion spread and opinion change; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
ID - 2005-10775-001
AN - 2005-10775-001
AU - Newman, Sidney H.
T1 - Improving the Evaluation of Submitted Manuscripts.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1966/10//
VL - 21
IS - 10
SP - 980
EP - 981
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2005-10775-001. PMID: 5918208 Partial author list: First Author & Affiliation: Newman, Sidney H.; United States Public Health Service, Washington, DC, US. Release Date: 20060327. Correction Date: 20100412. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Printed Communications Media; Scientific Communication. Minor Descriptor: Evaluation; Experimentation. Classification: Professional Psychological & Health Personnel Issues (3400). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 1966. Copyright Statement: American Psychological Association. 1966.
AB - This comment looks at the improvement of evaluation of submitted manuscripts. Topics discussed include: the importance of improving evaluations, developing operational standards and procedures, research to improve manuscript evaluation, publication problems, and the author's recommendations for action. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - submitted manuscripts
KW - evaluation
KW - standards
KW - research
KW - publication
KW - scientific communication
KW - 1966
KW - Printed Communications Media
KW - Scientific Communication
KW - Evaluation
KW - Experimentation
KW - 1966
DO - 10.1037/h0021046
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10775-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-03517-001
AN - 1967-03517-001
AU - HOWELL, MARGARET A.
T1 - Personal effectiveness of physicians in a federal health organization.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1966/12//
VL - 50
IS - 6
SP - 451
EP - 459
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 1967-03517-001. PMID: 5978037 Partial author list: First Author & Affiliation: HOWELL, MARGARET A.; U.S. PUBLIC HEALTH SERVICE, WASHINGTON, D.C. Release Date: 19670101. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Group Performance; Job Performance; Performance Tests; Personality Measures; Physicians. Minor Descriptor: California Psychological Inventory. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Dec, 1966. Copyright Statement: American Psychological Association. 1966.
AB - CONTRASTING HIGH (N = 156) AND LOW (N = 156) CRITERION GROUPS OF UNITED STATES PUBLIC HEALTH SERVICE PHYSICIANS WERE IDENTIFIED ON THE BASIS OF SPONTANEOUS COMMENTS ABOUT PERSONAL CHARACTERISTICS APPEARING IN SUPERVISORS' EFFICIENCY REPORTS. THE 2 GROUPS WERE COMPARED ON PERSONALITY INVENTORIES AND OTHER MEASURES. SIGNIFICANT GROUP DIFFERENCES (.10 LEVEL OR BELOW) WERE FOUND ON PERSONALITY INVENTORY SCALES, AN EMPLOYMENT SELECTION INTERVIEW, SCORES DERIVED FROM A REGRESSION EQUATION FOR THE CPI FOUND TO BE PREDICTIVE OF PERFORMANCE IN MEDICAL SCHOOL, SCORED SECTIONS OF SUPERVISORY EFFICIENCY REPORTS, AND IN ATTITUDES ABOUT THE EMPLOYMENT SITUATION. THE GROUPS DID NOT DIFFER ON MEASURES OF APTITUDE, ACHIEVEMENT, CREATIVITY, AND VALUES. DESCRIPTIONS OF THE CONTRASTING GROUPS WERE DEVELOPED FROM THE DISCRIMINATING PERSONALITY INVENTORY SCALES. THE TYPE OF PERSONALITY CRITERION EMPLOYED CAN BE USED WITH OTHER OCCUPATIONAL GROUPS. (25 REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PHYSICIAN EFFECTIVENESS
KW - FEDERAL HEALTH ORGANIZATION
KW - 1966
KW - Group Performance
KW - Job Performance
KW - Performance Tests
KW - Personality Measures
KW - Physicians
KW - California Psychological Inventory
KW - 1966
DO - 10.1037/h0024044
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-03517-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-11034-001
AN - 1968-11034-001
AU - Berman, Merrill I.
T1 - Mental retardation and depression.
JF - Mental Retardation
JO - Mental Retardation
JA - Ment Retard
Y1 - 1967///
VL - 5
IS - 6
SP - 19
EP - 21
CY - US
PB - American Assn on Mental Retardation
SN - 0047-6765
N1 - Accession Number: 1968-11034-001. PMID: 6082932 Other Journal Title: Intellectual and Developmental Disabilities. Partial author list: First Author & Affiliation: Berman, Merrill I.; U.s. Public Health Service Hosp., San Francisco, Calif. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19680101. Correction Date: 20170102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Depression (Emotion); Intellectual Development Disorder. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 3. Issue Publication Date: 1967.
AB - IN THE PSYCHIATRIC EVALUATION OF 50 4-35 YR. OLD MENTAL RETARDATES REFERRED MAINLY FOR MISBEHAVIOR, IT WAS FOUND THAT A MAJORITY SUFFERED FROM DEEP SEATED DEPRESSION. RATHER THAN PRESENTING CLASSICAL SYMPTOMS OF OVERT DEPRESSION, SS PRESENTED ANGRY, AVERSIVE BEHAVIOR AS A DEFENSIVE METHOD OF DEALING WITH OR AVOIDING FEELINGS OF HOPELESSNESS, HELPLESSNESS, AND SEVERELY LOW SELF-ESTEEM. IT WAS ALSO NOTED THAT THE STAFF MEMBERS SUFFERED FROM FEELINGS OF FUTILITY AND DEPRESSION WHICH CONTRIBUTED TO THE CYCLE OF MALADAPTIVE BEHAVIOR. IT IS SUGGESTED THAT OPERATIONAL DEFINITIONS OF DEPRESSION BE REDEFINED TO INCLUDE A MORE DESCRIPTIVE BEHAVIORAL DIAGNOSIS. GROUP THERAPY AND GROUP COUNSELING FOR PATIENTS AND STAFF ARE RECOMMENDED FOR THERAPEUTIC MANIPULATION OF THE ENVIRONMENT TO MAKE IT MORE GOAL-DIRECTED AND HELP DEAL WITH THE DEPRESSION. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - DEPRESSION SYMPTOMS
KW - 4-35 YR. OLD MENTAL RETARDATES
KW - 1967
KW - Depression (Emotion)
KW - Intellectual Development Disorder
KW - 1967
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-12671-001
AN - 1967-12671-001
AU - Fox, Bernard H.
T1 - Training and education in safety research.
JF - Traffic Safety Research Review
JO - Traffic Safety Research Review
Y1 - 1967///
VL - 11
IS - 2
SP - 42
EP - 49
N1 - Accession Number: 1967-12671-001. Partial author list: First Author & Affiliation: Fox, Bernard H.; U.s. Public Health Service, Washington, D.C. Release Date: 19670101. Correction Date: 20170223. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Accident Proneness; Accidents; Education; Safety. Minor Descriptor: Cerebrovascular Accidents. Classification: Industrial & Organizational Psychology (3600); Social Psychology (3000). Population: Human (10). Page Count: 8. Issue Publication Date: 1967.
AB - RESEARCH TRAINING IN ACCIDENT PREVENTION NEEDS TO BE CONSIDERED IN RELATION TO THOSE INVOLVED IN THE RESEARCH PROCESS: THE PRINCIPAL INVESTIGATOR, THE ADMINISTRATOR, THE CONSULTANT AND ASSISTING PERSONNEL, AND THE PUBLIC. THE NONRESEARCHER MUST BE INFORMED AS TO BACKGROUND TASKS AND GROUND RULES OF RESEARCH; THE RESEARCHER MUST BE INFORMED OF THE NONRESEARCHER'S PROBLEMS, ADMINISTRATIVE NEEDS, ATTITUDES AND THE NEED FOR DELIBERATION IN DEALING WITH COMMUNITY AND OTHER GROUPS. TRAINING REQUIRES SUPPORT FROM MANY SOURCES. SOME PROBLEMS AND POINTS OF VIEW ARE PRESENTED. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - SAFETY RESEARCH PERSONNEL
KW - & EDUCATION OF PUBLIC & PUBLIC OFFICIALS
KW - 1967
KW - Accident Prevention
KW - Accident Proneness
KW - Accidents
KW - Education
KW - Safety
KW - Cerebrovascular Accidents
KW - 1967
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-15906-001
AN - 1967-15906-001
AU - Howell, Margaret A.
AU - Newman, Sidney H.
T1 - Prediction of work area specialization among professional health personnel.
JF - Personnel Psychology
JO - Personnel Psychology
JA - Pers Psychol
Y1 - 1967///
VL - 20
IS - 2
SP - 89
EP - 110
CY - United Kingdom
PB - Blackwell Publishing
SN - 0031-5826
SN - 1744-6570
N1 - Accession Number: 1967-15906-001. Partial author list: First Author & Affiliation: Howell, Margaret A.; U.s. Public Health Service, Bethesda, MD. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19670101. Correction Date: 20170216. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Job Performance; Personnel; Prediction; Working Conditions. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Page Count: 22. Issue Publication Date: 1967.
AB - BIOGRAPHICAL INVENTORY RESPONSES, OBTAINED FROM 663 PERSONNEL AT PUBLIC HEALTH SERVICE CENTERS, WERE ITEM ANALYZED AND COMPARED WITH PERFORMANCE IN PROFESSIONAL HEALTH WORK. OCCUPATIONAL PROFILES WERE STUDIED. THE SCORES DID NOT PREDICT JOB PERFORMANCE BUT FUNCTIONAL-OCCUPATIONAL KEYS WERE DEVELOPED. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - WORK SPECIALIZATION/OF
KW - JOB PERFORMANCE
KW - PROFESSIONAL HEALTH PERSONNEL
KW - 1967
KW - Job Performance
KW - Personnel
KW - Prediction
KW - Working Conditions
KW - 1967
DO - 10.1111/j.1744-6570.1967.tb02272.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-15906-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-05987-001
AN - 1967-05987-001
AU - Nickols, J.
T1 - Rorschach Z scores on outpatients.
JF - Journal of Clinical Psychology
JO - Journal of Clinical Psychology
JA - J Clin Psychol
Y1 - 1967///
VL - 23
IS - 1
SP - 111
EP - 114
CY - US
PB - John Wiley & Sons
SN - 0021-9762
SN - 1097-4679
N1 - Accession Number: 1967-05987-001. PMID: 6031019 Other Journal Title: In Session: Psychotherapy in Practice. Partial author list: First Author & Affiliation: Nickols, J.; MENTAL HEALTH SERVICE, U.S. PUBLIC HEALTH SERVICE OUTPATIENT CLINIC, WASHINGTON, D.C. Release Date: 19670101. Correction Date: 20170220. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Psychiatric Patients; Rorschach Test; Thinking. Classification: Personality Psychology (3100). Population: Human (10). Page Count: 4. Issue Publication Date: 1967.
AB - RORSCHACH Z SCORES ON 20 CHILD AND 20 ADULT OUTPATIENTS WERE COMPARED WITH OTHER ASPECTS OF THE RORSCHACH, TESTS OF VERBAL THOUGHT SUCH AS THE AMMONS FULL RANGE PICTURE VOCABULARY, AND TESTS OF VISUAL THOUGHT SUCH AS THE STENCIL DESIGN TEST. Z WAS RELATED TO THE GRASPING OF RELATIONS AND EFFICIENCY OF MENTAL FUNCTIONS, AND SEEMED TO BE RELATED TO PRODUCTIVITY IN AN IMMEDIATE STIMULATION IN CHILDREN AND A READINESS IN ADULTS TO RELEASE DRIVE. 'A CONCILIATORY HYPOTHESIS WAS THAT BECK'S Z COULD PROVIDE AN INDEX TO ACCESSIBLE MENTAL DRIVE WHICH EMERGES IN THE RORSCHACH SITUATION.' (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - & VERBAL & VISUAL THOUGHT
KW - Z SCALE
KW - OUTPATIENTS
KW - 1967
KW - Psychiatric Patients
KW - Rorschach Test
KW - Thinking
KW - 1967
DO - 10.1002/1097-4679(196701)23:1<111::AID-JCLP2270230136>3.0.CO;2-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-05987-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-10762-001
AN - 1968-10762-001
AU - Linn, Erwin L.
T1 - The community, the mental hospital and psychotic patients' unusual behavior.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 1967///
VL - 145
IS - 6
SP - 492
EP - 499
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
N1 - Accession Number: 1968-10762-001. PMID: 6082141 Partial author list: First Author & Affiliation: Linn, Erwin L.; U.s. Public Health Service, Div. Of Dental Health, San Francisco, Calif. Release Date: 19680101. Correction Date: 20170102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Psychiatric Hospitalization; Psychiatric Hospitals; Psychiatric Patients; Psychosis. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 8. Issue Publication Date: 1967.
AB - FACTORS THAT LED TO THE INSTITUTIONALIZATION OF PATIENTS WERE RELATED TO FACTORS IN THE INSTITUTION THAT BROUGHT REMISSION. PRIMARILY, NORMS OF SOCIAL TOLERANCE OF UNUSUAL BEHAVIOR IN THE COMMUNITY REINFORCED SUCH BEHAVIOR WHEREAS THE NONACCEPTANCE OF CERTAIN BEHAVIORS IN THE HOSPITAL TENDED TOWARD THEIR ELIMINATION AND RETURN OF THE PATIENT TO THE COMMUNITY. PREVAILING THERAPY WAS ALSO A FACTOR. DURING THE SHOCK-THERAPY PERIOD, PATIENTS HAD A POORER CHANGE FOR REMISSION THAN DURING THE SUCCEEDING DRUG PERIOD. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - COMMUNITY & MENTAL HOSPITAL BEHAVIOR OF PSYCHOTICS & FACTORS LEADING TO INSTITUTIONALIZATION & REMISSION
KW - 1967
KW - Communities
KW - Psychiatric Hospitalization
KW - Psychiatric Hospitals
KW - Psychiatric Patients
KW - Psychosis
KW - 1967
DO - 10.1097/00005053-196712000-00007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-10762-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-02610-001
AN - 1968-02610-001
AU - NICKOLS, JOHN
T1 - EFFECTS OF GROUP PROJECTIVE TESTING ON RORSCHACH SCORES.
JF - Journal of Clinical Psychology
JO - Journal of Clinical Psychology
JA - J Clin Psychol
Y1 - 1967///
VL - 23
IS - 4
SP - 497
EP - 497
CY - US
PB - John Wiley & Sons
SN - 0021-9762
SN - 1097-4679
N1 - Accession Number: 1968-02610-001. Other Journal Title: In Session: Psychotherapy in Practice. Partial author list: First Author & Affiliation: NICKOLS, JOHN; MENTAL HEALTH SERVICES, U.S. PUBLIC HEALTH SERVICE OUTPATIENT CLINIC, WASHINGTON, D.C. Release Date: 19680101. Correction Date: 20130624. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Collective Behavior; Group Dynamics; Racial and Ethnic Groups; Rorschach Test; Social Groups. Minor Descriptor: Group Problem Solving. Classification: Personality Psychology (3100). Population: Human (10). Page Count: 1. Issue Publication Date: 1967.
AB - A SELF-ADMINISTERED GROUP RORSCHACH WAS GIVEN TO 2 GROUPS OF 18 SS EACH. EFFECTIVE Z SEEMED TO REPRESENT THE PATTERNS GIVEN ON THE INDIVIDUALIZED RORSCHACH. A HIGH CORRELATION WAS NOTED BETWEEN EFFECTIVE Z AND SUM C. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - GROUP TESTING
KW - 1967
KW - Collective Behavior
KW - Group Dynamics
KW - Racial and Ethnic Groups
KW - Rorschach Test
KW - Social Groups
KW - Group Problem Solving
KW - 1967
DO - 10.1002/1097-4679(196710)23:4<497::AID-JCLP2270230433>3.0.CO;2-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-02610-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-04208-001
AN - 1968-04208-001
AU - BRENNER, BERTHOLD
T1 - Alcoholism and fatal accidents.
JF - Quarterly Journal of Studies on Alcohol
JO - Quarterly Journal of Studies on Alcohol
JA - Q J Stud Alcohol
Y1 - 1967///
VL - 28
IS - 3
SP - 517
EP - 528
CY - US
PB - Alcohol Research Documentation
SN - 0033-5649
N1 - Accession Number: 1968-04208-001. PMID: 6048613 Other Journal Title: Journal of Studies on Alcohol; Journal of Studies on Alcohol and Drugs. Partial author list: First Author & Affiliation: BRENNER, BERTHOLD; DIV. OF ACCIDENT PREVENTION, PUBLIC HEALTH SERVICE, WASHINGTON, D.C. Release Date: 19680101. Correction Date: 20161020. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Accident Proneness; Accidents; Alcoholism; Cerebrovascular Accidents. Minor Descriptor: Death and Dying. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 12. Issue Publication Date: 1967.
AB - TO STUDY THE RELATIONSHIP BETWEEN ALCOHOLISM AND ACCIDENT MORTALITY, THE NUMBER OF ACCIDENTAL DEATHS AMONG 1343 SAN FRANCISCO BAY AREA ALCOHOLICS WAS COMPARED TO THAT EXPECTED ON THE BASIS OF THE AGE- AND SEX-SPECIFIC DEATH RATES FOR AREA RESIDENTS. THE ALCOHOLICS WERE SELECTED FROM AMONG THE ALCOHOLIC ADMISSIONS DURING 1954-1957 TO 4 ALCOHOLISM TREATMENT FACILITIES AND WERE FOLLOWED-UP THROUGH 1961 FOR A TOTAL OF 7289 MAN-YR.: 1401 OF THESE WERE CONTRIBUTED BY WOMEN; 1928 BY THOSE AGED UNDER 40; AND 2651 BY THOSE OVER 50. OF THE 1343 ALCOHOLICS, 217 DIED, 35 ACCIDENTALLY, 10 IN MOTOR VEHICLE ACCIDENTS, 14 IN FALLS, 6 BY POISONING, AND 5 IN OTHER ACCIDENTS. THE BEST ESTIMATE IS THAT DURING THE GIVEN PERIOD OF TIME THE ALCOHOLICS WERE 7 TIMES AS LIKELY TO BECOME THE VICTIM OF SOME TYPE OF FATAL ACCIDENT, WITH A RATE OF 480 DEATHS PER 100,000 MAN-YR., COMPARED WITH 69 IN THE WHOLE POPULATION. THE CIRCUMSTANCES OF DEATH ARE DISCUSSED, AND IT IS SUGGESTED THAT THE ELEVATED RATE OF ACCIDENT MORTALITY AMONG ALCOHOLICS REFLECTS NOT ONLY THE IMMEDIATE AFFECTS OF ALCOHOL, BUT ALSO THEIR LIFE PATTERN, PERSONALITY, STATE OF HEALTH, AND CARE RECEIVED WHEN ILL OR INJURED. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - FATAL ACCIDENTS
KW - 1967
KW - Accident Prevention
KW - Accident Proneness
KW - Accidents
KW - Alcoholism
KW - Cerebrovascular Accidents
KW - Death and Dying
KW - 1967
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-04208-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-18367-001
AN - 1968-18367-001
AU - DUKES-DOBOS, FRANCIS N.
AU - KEENAN, ROBERT G.
AU - CARLOW, THOMAS J.
T1 - Urinary mucoprotein excretion in physical exercise.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 1967///
VL - 9
IS - 6
SP - 595
EP - 601
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
N1 - Accession Number: 1968-18367-001. PMID: 5595122 Partial author list: First Author & Affiliation: DUKES-DOBOS, FRANCIS N.; U.S. DEPT. OF HEALTH, EDUCATION, + WELFARE, PUBLIC HEALTH SERVICE, CINCINNATI. Other Publishers: Sage Publications. Release Date: 19680101. Correction Date: 20161010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biochemistry; Excretion; Motor Performance; Physiology; Working Conditions. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Page Count: 7. Issue Publication Date: 1967.
AB - THE AVERAGE PATTERN OF URINARY MUCOPROTEIN (MP) EXCRETION WAS ASSESSED IN 4 SS DURING 104 WORKDAYS. THE SS WERE PERFORMING THEIR USUAL TASKS CONNECTED WITH THEIR JOBS. ON ALTERNATE DAYS THEY WERE EXPOSED TO AN ADDITIONAL TREADMILL EXERCISE FOR 1 HR. ON DAYS WITH TREADMILL EXERCISE MP EXCRETION WAS ELEVATED. THE TOTAL EXCESS MP EXCRETION WAS NOT SIGNIFICANTLY DIFFERENT WHETHER THE SS WALKED AT SPEEDS OF 2.4 OR 3.5 MPH. HOWEVER, THE RATE OF MP EXCRETION (MG/HR) INCREASED MORE DURING THE 3.5-MPH WALK THAN DURING THE 2.4-MPH. THIS SUGGESTS THAT THE MEASUREMENT OF THE URINARY MP EXCRETION RATE DURING PHYSICAL EXERCISE BE USEFUL IN DETERMING THE MAGNITUDE OF THE STRESS IMPOSED BY A WORKLOAD UPON AN INDIVIDUAL S. (16 REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MUCOPROTEIN/URINARY
KW - PHYSICAL EXERCISE
KW - 1967
KW - Biochemistry
KW - Excretion
KW - Motor Performance
KW - Physiology
KW - Working Conditions
KW - 1967
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-18367-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1969-11823-001
AN - 1969-11823-001
AU - Howell, Margaret A.
AU - Vincent, John W.
T1 - The Medical College Admission Test as related to achievement tests in medicine and to supervisory evaluations of clinical physicians.
JF - Journal of Medical Education
JO - Journal of Medical Education
Y1 - 1967///
VL - 42
IS - 11
SP - 1037
EP - 1044
CY - US
PB - Lippincott Williams & Wilkins
N1 - Accession Number: 1969-11823-001. PMID: 6074435 Other Journal Title: Academic Medicine. Partial author list: First Author & Affiliation: Howell, Margaret A.; U.S. Public Health Service, Bethesda, Md. Release Date: 19690801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Graduate Students; Military Psychology; Rating; Statistical Validity; Testing. Classification: Educational Psychology (3500); Military Psychology (3800). Population: Human (10). Page Count: 8. Issue Publication Date: 1967.
AB - Employed 123 clinical physicians in a predictive validation study of the Medical College Admission Test (MCAT) against the Commissioned Officers' Efficiency and Progress Report (COEPR) supervisory rating and the Medical Reserve Examination Form 2 (MRE-2). Scores on the MCAT and MRE-2 were intercorrelated with the COEPR. MCAT vs. COEPR correlations were found to be consistently negative, while MCAT substests significantly correlated (.01 level) with the total score of the MRE-2. Results 'indicate that MCAT . . . emphasizes abilities related to medical knowledge and application of knowledge in Preventive Medicine and Public Health and to a lesser extent in Medical Sciences.' The difficulty in 'developing appropriate performance criteria' in the medical profession is discussed. (17 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Medical College Admission Test validated against Commissioned Officers' Efficiency & Progress Report supervisory rating & Medical Reserve Examination Form 2
KW - 1967
KW - Graduate Students
KW - Military Psychology
KW - Rating
KW - Statistical Validity
KW - Testing
KW - 1967
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1969-11823-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1967-15911-001
AN - 1967-15911-001
AU - Howell, Margaret A.
AU - Vincent, John W.
AU - Gay, Richard A.
T1 - Testing aptitude for computer programming.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1967///
VL - 20
IS - 3, PT. 2
SP - 1251
EP - 1256
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1967-15911-001. PMID: 6082516 Partial author list: First Author & Affiliation: Howell, Margaret A.; U.s. Public Health Service, Bethesda, MD. Other Publishers: Sage Publications. Release Date: 19670101. Correction Date: 20170216. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aptitude Measures; Personnel Selection; Selection Tests; Statistical Validity; Test Validity. Minor Descriptor: Computers; Test Performance. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Page Count: 6. Issue Publication Date: 1967.
AB - EXPLORED THE USEFULNESS OF A SIMULATED WORK SAMPLE OF PROGRAMING (THE ROBOT TEST) AS A CRITERION FOR VALIDATING PROGRAMMER SELECTION TESTS. IN 2 SAMPLES OF CIVIL SERVICE EMPLOYEES, THIS TYPE OF CRITERION APPEARED QUITE PREDICTABLE, WITH MULTIPLE CORRELATIONS OF .6 (N = 135) AND .71 (N = 118). THE BEST PREDICTORS OF THOSE STUDIED WERE PARTS 2 AND 3 OF THE PROGRAMMER APTITUDE TESTS. IN 1 SAMPLE, THE ADDITION OF THE NUMERICAL PART OF THE FEDERAL SERVICE ENTRANCE EXAMINATION SIGNIFICANTLY IMPROVED PREDICTION OF THE CRITERION. FURTHER RESEARCH ON THE ROBOT TEST IS RECOMMENDED. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - COMPUTER PROGRAMERS
KW - APTITUDE TESTING & PERFORMANCE VALIDITY
KW - ROBOT TEST & PROGRAMMER APTITUDE TEST
KW - 1967
KW - Aptitude Measures
KW - Personnel Selection
KW - Selection Tests
KW - Statistical Validity
KW - Test Validity
KW - Computers
KW - Test Performance
KW - 1967
DO - 10.2466/pr0.1967.20.3c.1251
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-15911-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Reynolds, Michael D.
AU - Draine, Bruce
AU - Greenly, John
AU - Garland, David
AU - Pyenson, Lewis
AU - Schwartz, Richard A.
AU - Davison, Gerald C.
T1 -
JO - New Republic
JF - New Republic
J1 - New Republic
PY - 1967/02/18/
Y1 - 1967/02/18/
VL - 156
IS - 7
M3 - Letter
SP - 34
EP - 36
SN - 00286583
AB - Presents letters to the editor referencing articles and topics discussed in previous issues. "Sorry 'Bout That," which asked for statistics on Vietnam war casualties; "Who's Fit to Be Free," which demonstrated difficulties that arise when non-psychotic criminals are handled as though they were mentally ill; Comparison of the Supersonic Transport boom intensities with those generated by U.S. Air Force aircraft during the supersonic overflights of various cities.
KW - LETTERS to the editor
KW - WAR casualties -- Statistics
KW - MENTALLY ill
KW - CRIMINALS
KW - SUPERSONIC transport planes
N1 - Accession Number: 12033695; Source Information: 2/18/67, Vol. 156 Issue 7, p34; Subject Term: LETTERS to the editor; Subject Term: WAR casualties -- Statistics; Subject Term: MENTALLY ill; Subject Term: CRIMINALS; Subject Term: SUPERSONIC transport planes; Subject Term: ; Number of Pages: 3p; ; Document Type: Letter;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=mth&AN=12033695&site=ehost-live&scope=site
DP - EBSCOhost
DB - mth
ER -
TY - GEN
AU - Linnenberg Jr., Clem C.
T1 - Communications.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1967/03//
VL - 27
IS - 1
M3 - Letter
SP - 67
PB - Wiley-Blackwell
SN - 00333352
AB - Presents several letters to the editor referencing article and topic discusses in previous issues. Views on planning, programming and budgeting systems; Comments on resource allocation by the U.S. federal government; Observations on economic planning.
KW - BUDGET
KW - CENTRAL economic planning
KW - RESOURCE allocation
KW - FEDERAL government
KW - LETTERS to the editor
KW - PROGRAM budgeting
KW - DECISION making in public administration
KW - MATERIAL balances
KW - UNITED States
N1 - Accession Number: 4596748; Linnenberg Jr., Clem C. 1; Affiliations: 1: U. S. Public Health Service, Washington, D.C. 20201.; Issue Info: Mar67, Vol. 27 Issue 1, p67; Thesaurus Term: BUDGET; Thesaurus Term: CENTRAL economic planning; Thesaurus Term: RESOURCE allocation; Thesaurus Term: FEDERAL government; Subject Term: LETTERS to the editor; Subject Term: PROGRAM budgeting; Subject Term: DECISION making in public administration; Subject Term: MATERIAL balances; Subject: UNITED States; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 7p; Document Type: Letter
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Carrese, Louis M.
AU - Baker, Carl G.
T1 - THE CONVERGENCE TECHNIQUE: A METHOD FOR THE PLANNING AND PROGRAMMING OF RESEARCH EFFORTS.
JO - Management Science
JF - Management Science
Y1 - 1967/04//
VL - 13
IS - 8
M3 - Article
SP - B-420
EP - B-438
PB - INFORMS: Institute for Operations Research
SN - 00251909
AB - The difficulties encountered in attempts to apply directly some of the standard network analysis techniques to the planning of research programs are discussed. The particularized requirements for a planning system suitable for research efforts are identified, and a technique developed specifically for the planning and programming of research efforts is described. Basically, the technique involves the formulation of a series of flows and arrays depicting major program elements and individual projects, sequentially ordered on the basis of research logic, and graphically represented by a matrix which relates research performance to resources required (including personnel, materials, equipment and facilities, and funds). Because of the nature of research, the technique was developed to avoid the formulation of tight networks with sharp time-to-completion estimates for each project. The application of this technique to two biomedical research programs of the National Cancer Institute is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Management Science is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STOCHASTIC convergence
KW - NETWORK analysis (Planning)
KW - RESEARCH
KW - OPERATIONS research
KW - PRODUCTION scheduling
KW - PLANNING
KW - BUSINESS planning
KW - MEDICAL research
KW - MATRICES
KW - NETWORK analysis (Communication)
KW - UNITED States
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 7028113; Carrese, Louis M. 1; Baker, Carl G. 1; Affiliations: 1: National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland.; Issue Info: Apr1967, Vol. 13 Issue 8, pB-420; Thesaurus Term: STOCHASTIC convergence; Thesaurus Term: NETWORK analysis (Planning); Thesaurus Term: RESEARCH; Thesaurus Term: OPERATIONS research; Thesaurus Term: PRODUCTION scheduling; Thesaurus Term: PLANNING; Thesaurus Term: BUSINESS planning; Subject Term: MEDICAL research; Subject Term: MATRICES; Subject Term: NETWORK analysis (Communication); Subject: UNITED States ; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Friedman, Sandor A.
AU - Simmons, Earl M.
T1 - Diabetic peripheral neuropathy.
JO - Geriatrics
JF - Geriatrics
Y1 - 1967/05//
VL - 22
IS - 5
M3 - Article
SP - 141
EP - 148
SN - 0016867X
N1 - Accession Number: 17120994; Friedman, Sandor A. 1; Simmons, Earl M. 2; Source Information: May1967, Vol. 22 Issue 5, p141; Number of Pages: 8p; Illustrations: 1 Diagram; Document Type: Article; Full Text Word Count: 2900
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17120994&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Russek, Henry I.
T1 - Emotional stress in the etiology of coronary heart disease.
JO - Geriatrics
JF - Geriatrics
Y1 - 1967/06//
VL - 22
IS - 6
M3 - Article
SP - 84
EP - 89
SN - 0016867X
N1 - Accession Number: 17144983; Russek, Henry I. 1,2,3; Source Information: Jun1967, Vol. 22 Issue 6, p84; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 2314
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17144983&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1967-10970-001
AN - 1967-10970-001
AU - Chen, Martin K.
AU - Podshadley, Dale W.
AU - Shrock, John G.
T1 - A factorial study of some psychological, vocational interest, and mental ability variables as predictors of success in dental school.
JF - Journal of Applied Psychology
JO - Journal of Applied Psychology
JA - J Appl Psychol
Y1 - 1967/06//
VL - 51
IS - 3
SP - 236
EP - 241
CY - US
PB - American Psychological Association
SN - 0021-9010
SN - 1939-1854
N1 - Accession Number: 1967-10970-001. PMID: 6045627 Partial author list: First Author & Affiliation: Chen, Martin K.; U.s. Public Health Service, San Francisco, Calif. Release Date: 19670101. Correction Date: 20170223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Academic Achievement Prediction; Medical Students; Motor Performance; Occupational Interests; Personality. Classification: Educational Psychology (3500). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Jun, 1967. Copyright Statement: American Psychological Association. 1967.
AB - 32 MENTAL ABILITY, PAST-ACHIEVEMENT, MANUAL SKILL, PERSONALITY, AND VOCATIONAL INTEREST VARIABLES BELIEVED TO BE POTENTIALLY USEFUL IN THE SELECTION OF DENTAL STUDENTS WERE FACTOR ANALYZED TO DETERMINE THEIR FACTOR PATTERN IN RELATION TO THE CRITERION VARIABLE, THE DENTAL GRADE POINT AVERAGE. THEN THOSE VARIABLES WHICH SHARED COMMON FACTORS WITH THE CRITERION VARIABLE WERE USED AS INDEPENDENT VARIABLES IN A MULTIPLE-REGRESSION EQUATION FOR PREDICTIVE PURPOSES. FOR THE 72 DENTAL JUNIORS STUDIED, IT WAS FOUND THAT THERE WERE 2 COMMON FACTORS BETWEEN THE 'PREDICTOR' VARIABLES AND THE GRADE AVERAGE. 1 FACTOR, DECIDED TO BE ACADEMIC APTITUDE, WAS SIGNIFICANTLY LOADED IN 4 'PREDICTOR' VARIABLES BESIDES THE GRADE AVERAGE. THE OTHER FACTOR, RELATED TO MANUAL SKILL, WAS SIGNIFICANTLY LOADED IN 3 SUBTESTS OF A MANUAL SKILL TEST AND THE GRADE AVERAGE. ALL BUT 1 OF THE 7 'PREDICTOR' VARIABLES WERE USED IN THE PREDICTIVE EQUATION, 1 VARIABLE BEING DROPPED BECAUSE OF ITS LOW, THOUGH STATISTICALLY SIGNIFICANT, FACTOR LOADING. OF ALL THE VARIABLES, THE PREDENTAL GRADE AVERAGE WAS FOUND TO BE THE MOST IMPORTANT PREDICTOR OF SUCCESS IN DENTAL SCHOOL. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - DENTAL SCHOOL
KW - PAST ACHIEVEMENT & MANUAL SKILL & PERSONALITY & VOCATIONAL INTERESTS
KW - 1967
KW - Academic Achievement Prediction
KW - Medical Students
KW - Motor Performance
KW - Occupational Interests
KW - Personality
KW - 1967
DO - 10.1037/h0024680
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1967-10970-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Grant, Marie D.
T1 - Federal resources for training nursing personnel in the geriatric field.
JO - Geriatrics
JF - Geriatrics
Y1 - 1967/09//
VL - 22
IS - 9
M3 - Article
SP - 74
EP - 83
SN - 0016867X
N1 - Accession Number: 17184948; Grant, Marie D. 1; Source Information: Sep1967c, Vol. 22 Issue 9, p74; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 1660
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17184948&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Cheraskin, E.
AU - Ringsdorf, W. M.
AU - Setyaadmadja, A. T. S. H.
AU - Barrett, R. A.
T1 - Coronary proneness and carbohydrate metabolism.
JO - Geriatrics
JF - Geriatrics
Y1 - 1967/09//
VL - 22
IS - 9
M3 - Article
SP - 122
EP - 126
SN - 0016867X
N1 - Accession Number: 17184957; Cheraskin, E. 1; Ringsdorf, W. M. 2; Setyaadmadja, A. T. S. H. 3; Barrett, R. A. 3; Source Information: Sep1967c, Vol. 22 Issue 9, p122; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 1585
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Nichols, Owen D
T1 - Air pollution technical information processing - the microthesaurus approach
JO - American Documentation
JF - American Documentation
Y1 - 1968/01//
VL - 19
IS - 1
M3 - Article
SP - 66
EP - 70
SN - 0096946X
AB - The purpose of this report is to describe the microthesaurus approach to indexing technical literature, as asked within the air pollution technical information center (aptic) of the national center for air pollution control (nsapc). Using the thesaurus of air pollution terms as a base, a microthesaurus was constructed by dividing the field of air pollution and its effect into major catagories, such as humans and animals, plants and foods, pollutants, measurements, and others. These major catagories were further divided to subcatagories, such as respiratory disease suspended particulates, and materials deterioration. Finally, the subcatagories were reduced to very specific terms such as asthma, bronchitis, emphysema-all subordinate to respiratory diseases. Approximately 1,300 terms were arranged hierarchically on three display sheets with each term coded according to the number-color scheme of a junkers termatrex systems. These sheets were subsequently used to deep-index several thousands air pollution documents. It was concluded that the microthesaurus approach provided the following: (1) consistency of indexing; (2) elimination of coding and spelling errors; (3) retrieval of both broad and highly specific information; and (4) adaptability to manual and mechanized systems.
N1 - Accession Number: ISTA0301359; Nichols, Owen D 1; Affiliations: 1 : Air Pollution Technical Information Center, U. S. Public Health Service.; Source Info: January 1968, Vol. 19 Issue 1, p66; Note: Update Code: 0300; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0301359&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Tancredi, Samuel A.
AU - Nichols, Owen D.
T1 - Air Pollution Technical Information Processing -- the Microthesaurus Approach.
JO - American Documentation
JF - American Documentation
Y1 - 1968/01//
VL - 19
IS - 1
M3 - Article
SP - 66
EP - 70
SN - 0096946X
AB - The purpose of this report is to describe the microthesaurus approach to indexing technical literature, as used within the Air Pollution Technical Information Center (APTIC) of the National Center for Air Pollution Control (NSAPC). Using the Thesaurus of Air Pollution Terms as a base, a microthesaurus was constructed by dividing the field of air pollution and its effects into major categories such as Humans and Animals, Plants and Foods, Pollutants, Measurements, and others. These major categories were further divided to subcategories such as Respiratory Diseases, Suspended Particulates, and Materials Deterioration. Finally, the subcategories were reduced to very specific terms such as asthma, bronchitis, emphysema--all subordinate to Respiratory Diseases. Approximately 1,300 terms were arranged hierarchically on three display sheets with each term coded according to the number-color scheme of a Jonkers Termatrex system. These sheets were subsequently used to deep-index several thousand air pollution documents. It was concluded that the micro-thesaurus approach provided the following: (1) consistency of indexing; (2) elimination of coding and spelling errors; (3) retrieval of both broad and highly specific information; and (4) adaptability to manual and mechanized systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Documentation is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR pollution
KW - POLLUTANTS
KW - TECHNICAL literature
KW - WASTE products
KW - BRONCHITIS
KW - RESPIRATORY diseases
N1 - Accession Number: 16863724; Tancredi, Samuel A. 1; Nichols, Owen D. 1; Affiliations: 1: Air Pollution Technical information Center, National Center for Air Pollution Control, Bureau of Disease Prevention & Environmental Control, U.S. Department of Health, Education, and Welfare, Public Health Service.; Issue Info: Jan1968, Vol. 19 Issue 1, p66; Thesaurus Term: AIR pollution; Thesaurus Term: POLLUTANTS; Subject Term: TECHNICAL literature; Subject Term: WASTE products; Subject Term: BRONCHITIS; Subject Term: RESPIRATORY diseases; NAICS/Industry Codes: 423930 Recyclable Material Merchant Wholesalers; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562111 Solid Waste Collection; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Levy, Richard P
T1 - A physician oriented method for clinical information retrieval
JO - American Documentation
JF - American Documentation
Y1 - 1968/01//
VL - 19
IS - 1
M3 - Article
SP - 90
EP - 94
SN - 0096946X
AB - A system is described whereby a physician can, by use of a simple language, (drege-diabetes retrieval element generator and executor), effectively search a large amount of active clinical patient data. The language, which is in everyday use has been found to be easily learnable. The language allows partioning a file in a number of different ways, thus permitting the chronology of a patient's record to be a search parameter. The output from the search provides a count of the documents searched, the proportion that satisify the search, and the identifying numbers of those documents which contain the desired information. At the option of the user, the output may be supplemented by all or part of those documents which met the requirements of the search.
N1 - Accession Number: ISTA0301367; Levy, Richard P 1; Affiliations: 1 : U.s. Public Health Service.; Source Info: January 1968, Vol. 19 Issue 1, p90; Note: Update Code: 0300; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Madden, E. E.;
AU - Dreyfus, R. H.;
T1 - Outpatient pharmacy prescription automation. Part 1
CT - Outpatient pharmacy prescription automation. Part 1
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1968/01/01/
VL - 25
IS - Jan
SP - 20
EP - 25
SN - 00029289
AD - U.S. Public Health Service Hosp., New Orleans, LA
N1 - Accession Number: 15-2275; Language: English; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - The methodology used at the New Orleans Public Health Service Hospital to capture and process outpatient prescription data for tabulation of managerial and clinical reports using a computer is described. A specially designed carbon copy producing label is used to obtain a source document. Processing procedures and reports provided are briefly discussed and illustrated. Conversion from batch processing to online, real time applications is discussed as the next phase to be entered.
KW - Automation, data processing, computers--hospital pharmacy--prescriptions, outpatient, automated system described;
KW - Prescriptions--outpatients--computers, system for processing data described;
KW - Pharmacy, institutional, hospital--computers--prescriptions, outpatients, system described;
KW - Labels--prescriptions--computers, use, outpatients;
KW - Patients--outpatients--prescriptions, automated processing;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2007-19746-001
AN - 2007-19746-001
AU - Beebe, John E. III
T1 - Allowing the patient to call home: A therapy of acute schizophrenia.
JF - Psychotherapy: Theory, Research & Practice
JO - Psychotherapy: Theory, Research & Practice
JA - Psychotherapy (Chic)
Y1 - 1968///
VL - 5
IS - 1
SP - 18
EP - 20
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
N1 - Accession Number: 2007-19746-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Beebe, John E. III; U.S. Public Health Service Hospital, San Francisco, CA, US. Other Publishers: Educational Publishing Foundation. Release Date: 20080107. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Family Relations; Psychotherapy; Schizophrenia; Telephone Systems. Minor Descriptor: Psychotherapeutic Processes; Psychotherapeutic Techniques. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 1968. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1968.
AB - In recent years, psychotherapists of schizophrenia have learned to attend to family interaction patterns. My observations lead me to believe that the patient needs to be reconnected mainly to his own disturbing family. Indeed, I have come to regard as my first goal returning the patient to involvement in his difficult situation. Sometimes I have been able to accomplish this 'reconnecting' with nothing more elaborate than a telephone. I've found the telephone an ideal instrument for accomplishing my goal. The telephone enables distance even as it effects contact. It permits the patient to say to his family, 'I am still part of you even though I have had to leave you.' It lets the family know that whatever the problem may be, it is not so bad that the patient can't even talk to them. For both, the call serves to curb the fantasies which take over when there is no exchange. Above all, by allowing this contact, the therapist gives permission to the family to relate in a healthier fashion. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family interaction
KW - schizophrenia
KW - telephone
KW - therapy
KW - 1968
KW - Family Relations
KW - Psychotherapy
KW - Schizophrenia
KW - Telephone Systems
KW - Psychotherapeutic Processes
KW - Psychotherapeutic Techniques
KW - 1968
DO - 10.1037/h0088642
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19746-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-16226-001
AN - 1968-16226-001
AU - Howell, M. A.
AU - Brumback, G. B.
AU - Newman, S. H.
AU - Rizzo, J. R.
T1 - Work satisfaction and the retention of organizationally employed physicians.
JF - Personnel Psychology
JO - Personnel Psychology
JA - Pers Psychol
Y1 - 1968///
VL - 21
IS - 1
SP - 63
EP - 77
CY - United Kingdom
PB - Blackwell Publishing
SN - 0031-5826
SN - 1744-6570
N1 - Accession Number: 1968-16226-001. Partial author list: First Author & Affiliation: Howell, M. A.; U.S. PUBLIC HEALTH SERVICE, BETHESDA, MD. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19680101. Correction Date: 20161010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Government; Job Satisfaction; Occupational Choice; Organizations; Physicians. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Page Count: 15. Issue Publication Date: 1968.
AB - SERVICE EVALUATION QUESTIONNAIRE DATA WERE OBTAINED FROM 2 SAMPLES OF PUBLIC HEALTH SERVICE PHYSICIANS. FACTOR ANALYSES OF THE 47 ITEMS PLUS CRITERION AND OTHER DATA WERE MADE. COMPARISON OF THE RESULTS SUGGESTS THAT FOR THE PHYSICIANS, AS AN OCCUPATIONAL GROUP, ATTITUDES TOWARDS SPECIFIC ASPECTS OF A FEDERAL ORGANIZATION MAY HAVE LITTLE TO DO WITH CAREER CHOICES. PERSONAL MOTIVATIONS SUCH AS DESIRE FOR PRIVATE PRACTICE, OPPORTUNITIES FOR VARIOUS KINDS OF EMPLOYMENT OUTSIDE THE FEDERAL GOVERNMENT, AND ATTITUDES TOWARDS FEDERAL PROGRAMS MAY BE MORE RELEVANT TO RETENTION THAN ARE SPECIFIC ASPECTS OF THE ORGANIZATION. IN THE PRESENT STUDY, SELECTIVE SERVICE OBLIGATIONS, AND POSSIBLY TRAINING, APPEAR TO BE THE ONLY VARIABLES IMPORTANT TO PHYSICIANS IN DECIDING TO STAY IN. (19 REF.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - WORK SATISFACTION & RETENTION
KW - PUBLIC HEALTH SERVICE PHYSICIANS
KW - 1968
KW - Government
KW - Job Satisfaction
KW - Occupational Choice
KW - Organizations
KW - Physicians
KW - 1968
DO - 10.1111/j.1744-6570.1968.tb02288.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-18880-001
AN - 1968-18880-001
AU - CARPENTER, JOHN
AU - ALDRICH, C. KNIGHT
AU - BOVERMAN, HAROLD
T1 - The effectiveness of patient interviews: A controlled study of emotional support during pregnancy.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1968///
VL - 19
IS - 1
SP - 110
EP - 112
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1968-18880-001. PMID: 5658375 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: CARPENTER, JOHN; U.S. PUBLIC HEALTH SERVICE HOSP., BRIGHTON, MASS. Release Date: 19680101. Correction Date: 20161010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Anxiety; Drug Therapy; Interviewing; Interviews; Psychotherapy. Minor Descriptor: Pregnancy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Methodology: Interview. Page Count: 3. Issue Publication Date: 1968.
AB - COMPARED TO A CONTROL GROUP WITHOUT INTERVIEWS, PREGNANT PATIENTS WHO HAD BEEN INTERVIEWED PERIODICALLY BY 1ST-YR MEDICAL STUDENTS: (1) REPORTED FEELING LESS NERVOUS AND ON EDGE DURING PREGNANCY, (2) REPORTED FEELING LESS WORRIED AND CONCERNED DURING LABOR, AND (3) REQUIRED LESS NARCOTIC MEDICATION AND TRANQUILIZING MEDICATION PRIOR TO DELIVERY. THE AMOUNT OF MEDICATION PRIOR TO DELIVERY WAS INVERSELY RELATED TO THE NUMBER OF INTERVIEWS WITH STUDENTS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PREGNANT WOMEN
KW - PERIODIC INTERVIEWS BY 1ST YR. MEDICAL STUDENTS
KW - NERVOUSNESS & NEED FOR MEDICATION
KW - 1968
KW - Anxiety
KW - Drug Therapy
KW - Interviewing
KW - Interviews
KW - Psychotherapy
KW - Pregnancy
KW - 1968
DO - 10.1001/archpsyc.1968.01740070112016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1968-18880-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1969-11989-001
AN - 1969-11989-001
AU - Lee, C. Bruce
T1 - Ecology and development.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 1968///
VL - 10
IS - 6
SP - 569
EP - 570
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
N1 - Accession Number: 1969-11989-001. Partial author list: First Author & Affiliation: Lee, C. Bruce; Public Health Service, Cincinnati, O. Other Publishers: Sage Publications. Release Date: 19690801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Business; Countries; Engineering Psychology; Environment. Classification: Engineering & Environmental Psychology (4000). Population: Human (10). Page Count: 2. Issue Publication Date: 1968.
AB - Stresses the ecologist's point of view in developing countries: (1) The human factors specialist must stress the systems approach involving reciprocity between man and his total environment. (2) He must acquaint himself with the cultures of the people of the area, estimating how these factors will jibe with any technologcal advance he may bring in. (3) Agencies engaged in natural resources activities should be utilized in the maintenance and enhancement of the environment. (4) The human factors specialst should integrate his plans and programs with other specialists in his own and related fields. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developing countries
KW - ecologist's point of view & human factors concepts
KW - 1968
KW - Business
KW - Countries
KW - Engineering Psychology
KW - Environment
KW - 1968
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1968-14876-001
AN - 1968-14876-001
AU - Lucaccini, Luigi F.
AU - Freedy, Amos
AU - Lyman, John
T1 - Motivational factors in vigilance: Effects of instructions on performance in a complex vigilance task.
JF - Perceptual and Motor Skills
JO - Perceptual and Motor Skills
JA - Percept Mot Skills
Y1 - 1968///
VL - 26
IS - 3, PT. 1
SP - 783
EP - 786
CY - US
PB - Perceptual & Motor Skills
SN - 0031-5125
SN - 1558-688X
N1 - Accession Number: 1968-14876-001. Other Journal Title: Perceptual & Motor Skills Research Exchange. Partial author list: First Author & Affiliation: Lucaccini, Luigi F.; U.s. Public Health Service, Dental Health Center, San Francisco, Calif. Other Publishers: Sage Publications. Release Date: 19680101. Correction Date: 20161229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Expectations; Experimental Instructions; Motivation; Response Set; Vigilance. Classification: Human Experimental Psychology (2300). Population: Human (10). Page Count: 4. Issue Publication Date: 1968.
AB - PRETASK INSTRUCTIONS HAVE BEEN A NEGLECTED SOURCE OF MOTIVATION IN VIGILANCE. 32 SS MONITORED A COMPLEX VISUAL VIGILANCE DISPLAY FOR 40 MIN. WITH A SIGNAL RATE OF 60/HR. 16 SS WERE TOLD THAT SUCH TASKS ARE USUALLY CHALLENGING AND 16 WERE TOLD SUCH TASKS ARE USUALLY MONOTONOUS. PERFORMANCE WAS SIGNIFICANTLY BETTER THROUGHOUT THE SESSION BY SS WITH THE POSITIVE SET AND DECREMENTS DID NOT OCCUR WITH EITHER GROUP. THE RESULTS INDICATE THE IMPORTANCE OF MOTIVATIONAL FACTORS IN VIGILANCE. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MOTIVATION FACTORS
KW - VISUAL TASK
KW - 1968
KW - Expectations
KW - Experimental Instructions
KW - Motivation
KW - Response Set
KW - Vigilance
KW - 1968
DO - 10.2466/pms.1968.26.3.783
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1969-09627-001
AN - 1969-09627-001
AU - Zwicker, Bonnie L.
T1 - Behavioral effects of attitudinal change.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1968///
VL - 23
IS - 3, Pt. 1
SP - 839
EP - 842
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1969-09627-001. Partial author list: First Author & Affiliation: Zwicker, Bonnie L.; Public Health Service, Arlington, Va. Other Publishers: Sage Publications. Release Date: 19690701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Behavior; Communication; Persuasive Communication. Classification: Social Psychology (3000). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Page Count: 4. Issue Publication Date: 1968.
AB - Examined the behavioral effects of attitude change induced by a communication. 38 teen-agers were exposed to 2 communications concerning diabetes. These differed in high and moderate intensity in presenting diabetes as a serious disease which teen-agers could contract along with the benefits of diagnostic diabetes tests. Attitudes concerning diabetes were assessed and Ss were offered a diabetes diagnostic test. Results showed that the S's perception of vulnerability toward the disease affected his participation in the test. The communication altered general attitudes about diabetes but failed to change any of their underlying components. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral effects of attitude change by communication
KW - teenagers
KW - 1968
KW - Attitudes
KW - Behavior
KW - Communication
KW - Persuasive Communication
KW - 1968
DO - 10.2466/pr0.1968.23.3.839
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1990-55841-001
AN - 1990-55841-001
AU - Newman, Sidney H.
AU - Ali, Marie
T1 - How psychologists are utilized in the United States Public Health Service.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1968/02//
VL - 23
IS - 2
SP - 139
EP - 141
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1990-55841-001. Partial author list: First Author & Affiliation: Newman, Sidney H.; US Public Health Service, Bethesda, MD, US. Release Date: 19900101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Government Agencies; Psychologists; Public Health Services. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 3. Issue Publication Date: Feb, 1968. Copyright Statement: American Psychological Association. 1968.
AB - Conducted a study of 234 psychologists employed by the US Public Health Service (USPHS) as of May 1966 and compared the results to national studies conducted by B. E. Compton (1966) and R. F. Lockman (1962) on functional and specialty areas of psychologists. 41% of the USPHS psychologists were involved in research, 43% in administration and consulting, 12% in practice, and 4% in other activities. The studies of Compton and Lockman found more psychologists in practice and teaching. USPHS psychologists involved in research were concentrating on the areas of developmental, clinical, experimental and physiological, and social psychology, working mainly for the National Institute of Mental Health. USPHS also provided an in-service program in grants administration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment by US Public Health Service
KW - psychologists
KW - 1968
KW - Employment Status
KW - Government Agencies
KW - Psychologists
KW - Public Health Services
KW - 1968
DO - 10.1037/h0037701
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1990-55841-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Camp, Paul M.
AU - Lomax, W. Richard
T1 - BILATERALISM AND THE MERIT PRINCIPLE.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1968/03//Mar/Apr68
VL - 28
IS - 2
M3 - Article
SP - 132
EP - 137
PB - Wiley-Blackwell
SN - 00333352
AB - The article presents information on bilateralism. In the public service, people have seen the unilateral development of merit systems to guard against improper influence in the filling of career positions. The word "unilateral" is italicized because this is the key feature of merit systems to which the labor-affiliated and other public employee organizations now strenuously object. Is collective negotiation theoretically consistent with merit principles? What do people mean by "merit"? Does it mean the traditional union concept of "seniority"? Since there are so many different employee organizations, it is doubtful that a generally accepted union definition could be found. Most of the unions on the federal scene have generally endorsed the merit principle, but in the specific application of this principle they have expressed views which some federal personnel administrators believe constitute a threat to civil service.
KW - PUBLIC administration
KW - PUBLIC sector
KW - COLLECTIVE bargaining
KW - ORGANIZATION
KW - LABOR unions
KW - CIVIL service
KW - LABOR
KW - MUNICIPAL services
KW - CIVIL service reform
KW - UNITED States
N1 - Accession Number: 4597565; Camp, Paul M. 1; Lomax, W. Richard 1; Affiliations: 1: U.S. Public Health Service.; Issue Info: Mar/Apr68, Vol. 28 Issue 2, p132; Thesaurus Term: PUBLIC administration; Thesaurus Term: PUBLIC sector; Thesaurus Term: COLLECTIVE bargaining; Thesaurus Term: ORGANIZATION; Thesaurus Term: LABOR unions; Thesaurus Term: CIVIL service; Thesaurus Term: LABOR; Subject Term: MUNICIPAL services; Subject Term: CIVIL service reform; Subject: UNITED States; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; NAICS/Industry Codes: 925110 Administration of Housing Programs; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 813930 Labor Unions and Similar Labor Organizations; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Campbell, Arthur A.
T1 - The Role of Family Planning in the Reduction of Poverty.
JO - Journal of Marriage & Family
JF - Journal of Marriage & Family
Y1 - 1968/05//
VL - 30
IS - 2
M3 - Article
SP - 236
EP - 245
SN - 00222445
AB - The prevention of unwanted births would have a substantial economic impact on families living in poverty. Using conservative assumptions, the costs of family-planning programs are estimated to average $300 to prevent every unwanted birth that would otherwise have occurred. Over the years, however, the avoidance of an unwanted child would save the family an average of $8,000 in the costs of child care. It would also enable couples to add an average of $600 to their annual incomes over a four-year period by making it possible for some of the wives to work. When all of these savings and added earnings are discounted to the year in which the unwanted births were prevented, the total economic benefits average $7,800 for every $300 spent on family-planning services. The ratio of benefits to costs is 26 to 1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Marriage & Family is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIRTH control
KW - POVERTY
KW - CHILD care
KW - MARRIED women
KW - PRIMARY care (Medicine)
KW - UNITED States
KW - Economic factors affecting tension
KW - INTERNATIONAL LAW, ECONOMICS, AND DIPLOMACY
KW - Population Characteristics and Conditions
N1 - Accession Number: 16640589; Campbell, Arthur A. 1; Affiliations: 1 : Chief, Natality Statistics Branch, National Center for Health Statistics, U.S. Public Health Service.; Source Info: May68, Vol. 30 Issue 2, p236; Subject Term: BIRTH control; Subject Term: POVERTY; Subject Term: CHILD care; Subject Term: MARRIED women; Subject Term: PRIMARY care (Medicine); Subject: UNITED States; Author-Supplied Keyword: Economic factors affecting tension; Author-Supplied Keyword: INTERNATIONAL LAW, ECONOMICS, AND DIPLOMACY; Author-Supplied Keyword: Population Characteristics and Conditions; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
AU - Bowen, W. J.
AU - Evans Jr., T. C.
T1 - The Binding of ATP to Myosins B and A.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/09//
VL - 5
IS - 4
M3 - Article
SP - 507
EP - 512
SN - 00142956
AB - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphatecreatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphate
KW - MYOSIN
KW - NUCLEOTIDES
KW - PROTEINS
KW - BIOCHEMISTRY
KW - CREATINE
N1 - Accession Number: 12791312; Bowen, W. J. 1,2; Evans Jr., T. C. 1,3; Source Information: 1968, Vol. 5 Issue 4, p507; Subject: ADENOSINE triphosphate; Subject: MYOSIN; Subject: NUCLEOTIDES; Subject: PROTEINS; Subject: BIOCHEMISTRY; Subject: CREATINE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Boyle Jr., Edwin
AU - Morales, Ismael Bob
AU - Nichaman, Milton Z.
AU - Talbert Jr., Clifford R.
AU - Watkins, Robert S.
T1 - Serum beta lipoproteins and cholesterol in adult men.
JO - Geriatrics
JF - Geriatrics
Y1 - 1968/12//
VL - 23
IS - 12
M3 - Article
SP - 102
EP - 111
SN - 0016867X
N1 - Accession Number: 17432910; Boyle Jr., Edwin 1; Morales, Ismael Bob 2; Nichaman, Milton Z. 3; Talbert Jr., Clifford R. 3; Watkins, Robert S. 4; Source Information: Dec1968, Vol. 23 Issue 12, p102; Number of Pages: 10p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article; Full Text Word Count: 3253
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17432910&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - Gen
ID - 9999-00294-000
AN - 9999-00294-000
AU - Horn, Daniel
T1 - Smoker's Self-Testing Kit
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1969///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-00294-000. Partial author list: First Author & Affiliation: Horn, Daniel; US Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, United States. Release Date: 20111010. Correction Date: 20151109. Instrument Type: Test. Test Format: Items on Test 1 are rated on a 4-point Likert scale ranging from 4 (completely agree) to 1 (completely disagree). Items on Test 2 are rated on a 4-point Likert scale ranging from 4 (strongly agree) to 1 (strongly disagree). Items on Test 3 are rated on a 5-point Likert scales ranging from 5 (always) to 1 (never). Items on Test 4 use a true/false response format.. Language: English. Supporting Documentation: Lessons with Tests; Constructs: Beliefs About Smoking; Decision Making; Smoking Habits; Classification: Addiction, Gambling, and Substance Abuse/Use (5000). Population: Human (10).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the tests is to develop your insight to help understand smoking habits and to aid decisions to quit smoking.
AB - Description: The Smoker's Self-Testing Kit is included through collaboration with The University of Akron, The Archives of the History of American Psychology, University Libraries. The kit was published by the US Department of Health Education and Welfare in 1969. It contains four short tests to help assessing knowledge and feelings about cigarette smoking. The purpose of the tests is to develop your insight to help understand smoking habits and to aid decisions to quit smoking. Test 1 (Do You Want to Change Your Smoking Habits?) contains 12 items; Test 2 (What Do You Think the Effects of Smoking Are?) contains 12 items. Test 3 (Why Do You Smoke?) contains 18 items; and Test 4 (Does the World Around You Make It Easier or Harder to Change Your Smoking Habits?) contains 13 items. Scoring instructions are provided on each test. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Smoker's Self-Testing Kit
KW - Cigarette Smoking
KW - Knowledge & Feelings
KW - Smoking Habits
KW - Decisions to Quit Smoking
U5 - Smoker's Self-Testing Kit [Test Primary Data] Administration: Paper Population: Human; Keywords: Smoker's Self-Testing Kit; Cigarette Smoking; Knowledge & Feelings; Smoking Habits; Decisions to Quit Smoking; Subjects: Decision Making; Knowledge (General); Smoking Cessation; Tobacco Smoking;
DO - 10.1037/t00294-000
L3 - http://supp.apa.org/psyctests/supporting/999900294/aabfbx942iot.html
L3 - Full; Full text; 999900294_full_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-00294-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 1970-10537-001
AN - 1970-10537-001
AU - Van Son, Marie H.
AU - Powder, Phyllis
T1 - Experience on an ambulatory psychiatric service.
JF - Nursing Outlook
JO - Nursing Outlook
Y1 - 1969///
VL - 17
IS - 10
SP - 58
EP - 59
N1 - Accession Number: 1970-10537-001. PMID: 5194775 Partial author list: First Author & Affiliation: Van Son, Marie H.; U.S. Public Health Service Hosp., Boston, Mass. Release Date: 19700701. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Clinics; Graduate Psychology Education; Nurses; Outpatient Treatment; Psychiatric Hospital Programs. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 2. Issue Publication Date: 1969.
AB - Participation in the psychotherapeutic interview in the outpatient department of a mental hospital as part of the basic clinical experience was seen to provide a successful new learning experience for student nurses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - training of student nurses
KW - participation in psychotherapeutic interview in hospital's outpatient clinic
KW - 1969
KW - Clinics
KW - Graduate Psychology Education
KW - Nurses
KW - Outpatient Treatment
KW - Psychiatric Hospital Programs
KW - 1969
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1970-10537-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1970-14433-001
AN - 1970-14433-001
AU - Bagwell, H. Roberts
T1 - The abrupt religious conversion experience.
JF - Journal of Religion and Health
JO - Journal of Religion and Health
JA - J Relig Health
Y1 - 1969///
VL - 8
IS - 2
SP - 163
EP - 178
CY - US
PB - Kluwer Academic/Plenum Publishers
SN - 0022-4197
SN - 1573-6571
N1 - Accession Number: 1970-14433-001. PMID: 24419990 Partial author list: First Author & Affiliation: Bagwell, H. Roberts; U.S. Public Health Service Hosp., San Francisco, Calif. Release Date: 19700901. Correction Date: 20151207. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Ego; Personality Change; Personality; Phenomenology; Religion. Minor Descriptor: Religious Conversion; Reintegration. Classification: Social Processes & Social Issues (2900). Population: Human (10). Page Count: 16. Issue Publication Date: 1969.
AB - Explored the psychological conceptualizations of conversion from a historical perspective and from contemporary formulations. From a review of the literature it is concluded that: 'The phenomenological event is the interpretation of paired changes in the level of ego functioning an acute regression followed closely by a sudden reintegration. There seems to be no particular specificity to the initial regression to distinguish it from other regressions. There is a good deal of variation in the degree of regression from individual to individual, but some disjunctive experience of regression has been repeatedly reported as a phenomenologic constant. The reintegration may be transient or long lasting. In some individuals, the reintegration is at a more adaptive level than the preconversion state, but the reintegration may itself be at a regressed level. When this occurs it does not preclude a later change to a more adaptational adjustment, but it may be an abiding move into frank psychopathology.' (77 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological factors of abrupt religious conversion
KW - ego functioning level & regression & reintegration
KW - historical & contemporary perspectives
KW - 1969
KW - Ego
KW - Personality Change
KW - Personality
KW - Phenomenology
KW - Religion
KW - Religious Conversion
KW - Reintegration
KW - 1969
DO - 10.1007/BF01533143
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1970-14433-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1970-06081-001
AN - 1970-06081-001
AU - Ebbesson, Sven O.
AU - Rubinson, Kalman
T1 - A simplified nauta procedure.
JF - Physiology & Behavior
JO - Physiology & Behavior
JA - Physiol Behav
Y1 - 1969///
VL - 4
IS - 2
SP - 281
EP - 282
CY - Netherlands
PB - Elsevier Science
SN - 0031-9384
N1 - Accession Number: 1970-06081-001. Partial author list: First Author & Affiliation: Ebbesson, Sven O.; U. S. Public Health Service, Dept. of Health, Education, & Welfare, San Juan, Puerto Rico. Release Date: 19700101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Methodology; Neurology. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Page Count: 2. Issue Publication Date: 1969.
AB - Describes an improved and simplified procedure for the selective silver impregnation of degenerating axons. The modification consists of soaking the sections in .01% potassium permanganate overnight after treatment in a 5% uranyl nitrate solution. This pretreatment apparently requires no modification for different brains, as did the original technique. This standardized method has been used successfully in studies on sharks, teleosts, amphibians, reptiles, birds, and mammals. Some advantages of the procedure are that the impregnation of degenerating axoplasm is enhanced, the results are easily reproducible, and technician time is substantially reduced. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - simplified nauta procedure for selective silver impregnation of degenerating axons
KW - 1969
KW - Brain
KW - Methodology
KW - Neurology
KW - 1969
DO - 10.1016/0031-9384(69)90096-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1970-06081-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1970-06994-001
AN - 1970-06994-001
AU - Skelton, W. Douglas
T1 - Prison riot: Assaulters vs. defenders.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1969///
VL - 21
IS - 3
SP - 359
EP - 362
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1970-06994-001. PMID: 5806036 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Skelton, W. Douglas; U. S. Public Health Service, Robert F. Kennedy Youth Center, Morgantown, W. Va. Release Date: 19700101. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Aggressive Behavior; Crime; Criminals; Prisons. Minor Descriptor: Educational Background. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 4. Issue Publication Date: 1969.
AB - Following a riot at a federal reformatory, 2 groups of inmates, assaulters and defenders, were identified and analyzed using information from case histories. Results show that assaulters were younger, had more violent behavior in the past, and were described as 'resentful of authority.' Racial characteristics, parental separation or divorce, average age of 1st arrest, school grade completed, intelligence scores, use of forcible restraint, and drug abuse did not differentiate the 2 groups. High incidence of emotional disturbances, paranoid trends, and sexual psychopathology in assaulters suggest that in depth individual study of violent persons should complement attempts to define group dynamics. Findings indicate that, whatever the grievances of the rioters as a group, many assaulters act in a way representative of their previous behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prison riot
KW - assaulters vs. defenders
KW - demographic characteristics
KW - 1969
KW - Age Differences
KW - Aggressive Behavior
KW - Crime
KW - Criminals
KW - Prisons
KW - Educational Background
KW - 1969
DO - 10.1001/archpsyc.1969.01740210103015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1970-06994-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Madden, E. E.;
AU - Vaughan, C. M.;
AU - Trahan, G. J.;
T1 - Outpatient pharmacy prescription automation. Part 2
CT - Outpatient pharmacy prescription automation. Part 2
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1969/03/01/
VL - 26
IS - Mar
SP - 151
EP - 159
SN - 00029289
AD - U.S. Public Health Service Hosp., New Orleans, LA
N1 - Accession Number: 15-3200; Language: English; References: 2; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - The use of a computer to improve patient care in an outpatient pharmacy is described. As the pharmacist enters the desired label information on a typewriter like keyboard, the information is displayed on a cathode ray screen and then transmitted via telephone lines to a computer. After computer editing and checking, the formatted prescription label or warning message is displayed for the pharmacist's approval prior to printing of the label. Factors also considered are: time saved through the use of various computer techniques; overdose, contraindication and drug sensitivity alert; improved prescription labels; and availability of management data. Computer hardware and processing are also described.
KW - Automation, data processing, computers--hospital pharmacy--use, improved, outpatient care;
KW - Patients--outpatients--computers, use, to improve care;
KW - Pharmacy, institutional, hospital--computers--use, improving outpatient care;
KW - Prescriptions--computers--use, to improve outpatient care;
KW - Labeling--prescriptions--computers, use, outpatient department;
KW - Toxicity--drugs--prescriptions, computer generated labels with warning message;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=15-3200&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Connor, Robert J.
AU - Mosimann, James E.
T1 - CONCEPTS OF INDEPENDENCE FOR PROPORTIONS WITH A GENERALIZATION OF THE DIRICHLET DISTRIBUTION.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1969/03//
VL - 64
IS - 325
M3 - Article
SP - 194
SN - 01621459
AB - Concepts of independence for nonnegative continuous random variables, X[sub 1],..., X[sub k], subject to the constraint SIGMA X[sub i] = 1 are developed. These concepts provide a means of modeling random vectors of proportions which is useful in analyzing certain kinds of data; and which may be of interest in quantifying prior opinions about multinomial parameters. A generalization of the Dirichlet distribution is given, and its relation to the Dirichlet is simply indicated by means of the concepts. The concepts are used to obtain conclusions of biological interest for data on bone composition in rats and scute growth in turtles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANDOM variables
KW - DISTRIBUTION (Probability theory)
KW - STATISTICS
KW - PROBABILITY theory
KW - INDEPENDENCE (Mathematics)
KW - DIRICHLET principle
KW - GENERALIZATION
KW - BIOLOGICAL assay
KW - VARIABLES (Mathematics)
N1 - Accession Number: 4603649; Connor, Robert J. 1; Mosimann, James E. 1; Affiliations: 1: National Institutes of Health, Public Health Service; Issue Info: Mar1969, Vol. 64 Issue 325, p194; Thesaurus Term: RANDOM variables; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STATISTICS; Thesaurus Term: PROBABILITY theory; Subject Term: INDEPENDENCE (Mathematics); Subject Term: DIRICHLET principle; Subject Term: GENERALIZATION; Subject Term: BIOLOGICAL assay; Subject Term: VARIABLES (Mathematics); Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Verhulst, Henry L
T1 - Information to and from poison control centers
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1969/05//
VL - 9
IS - 2
M3 - Article
SP - 71
EP - 73
SN - 00219576
AB - The collection of significant information about the effects of chemicals and chemical combinations on the human body depends on knowledge of the formulation and a complete medical resume of resulting illness. The rate of collection of such information is retarded by lack of information on complete formulations, necessity to remove suspect offending agent from the stomach immediately, and lack of laboratory facilities to do blood chemistry on complex drugs and chemicals.
N1 - Accession Number: ISTA0502016; Verhulst, Henry L 1; Affiliations: 1 : U.s. Public Health Service, Silver Spring, Maryland.; Source Info: May 1969, Vol. 9 Issue 2, p71; Note: Update Code: 0500; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA0502016&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Dalrymple, B. A.;
AU - Kenner, C. T.;
T1 - Determination of calcium in pharmaceutical preparations by atomic absorption spectrometry
CT - Determination of calcium in pharmaceutical preparations by atomic absorption spectrometry
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/05/01/
VL - 58
IS - May
SP - 604
EP - 606
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 7-1015; Language: English; Chemical Name: Calcium--7440-70-2; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Calcium--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1015&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Prosser, A. R.;
AU - Sheppard, A. J.;
T1 - Gas-liquid chromatographic determination of pantothenates and panthenol
CT - Gas-liquid chromatographic determination of pantothenates and panthenol
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/06/01/
VL - 58
IS - Jun
SP - 718
EP - 721
SN - 00223549
AD - Division of Nutrition, Food and Drug Administration, Department of Health, Education and Welfare, Washington, D. C. 20204
N1 - Accession Number: 7-1011; Language: English; Chemical Name: Panthenol--16485-10-2 Pantothenic acid--79-83-4; References: 17; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - GLC can be used to detect and analyze pantothenic acid salts and panthenol as acetyl derivatives, and offers a unique advantage in speed of separation, sensitivity, and convenience. The procedure is very sensitive; as little as 0.25 mcg. can be detected. Chromatograms are included.
KW - Panthenol--and pantothenates-;
KW - Pantothenic acid--salts-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1011&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Diliberto, J. J.;
T1 - Application of magnesium silicate adsorption chromatography to the determination of mephobarbital and diphenylhydantoin in tablets
CT - Application of magnesium silicate adsorption chromatography to the determination of mephobarbital and diphenylhydantoin in tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/06/01/
VL - 58
IS - Jun
SP - 747
EP - 749
SN - 00223549
AD - U.S. Department of Health, Education and Welfare, Food and Drug Administration, Buffalo District, Buffalo, New York 14202
N1 - Accession Number: 7-1013; Language: English; Chemical Name: Diphenylhydantoin--57-41-0 Mephobarbital--115-38-8; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Diphenylhydantoin--and mephobarbital-;
KW - Mephobarbital--and diphenylhydantoin-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1013&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jeffus, M. T.;
AU - Kenner, C. T.;
T1 - Determination of niacinamide in pharmaceutical preparations
CT - Determination of niacinamide in pharmaceutical preparations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/06/01/
VL - 58
IS - Jun
SP - 749
EP - 752
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 7-1450; Language: English; Trade Name: Niacinamide; Generic Name: Nicotinamide; References: 17; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - This paper reports 2 methods using column chromatographic separation followed by measurement of the UV absorbance of niacinamide (nicotinamide) in 0.1N HCl or of the color developed by niacinamide with bromothymol blue in chloroform solution. The methods are simple, specific, and show accuracy and precision equivalent to or better than the cyanogen bromide methods.
KW - Nicotinamide--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1450&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levine, J.;
AU - Maienthal, M.;
T1 - Quinidine transformation product isolated from quinidine injection
CT - Quinidine transformation product isolated from quinidine injection
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/06/01/
VL - 58
IS - Jun
SP - 770
EP - 771
SN - 00223549
AD - Division of Pharmaceutical Sciences, Food and Drug Administration, U. S. Department of Health, Education and Welfare, Washington, D. C. 20204
N1 - Accession Number: 7-0934; Language: English; Chemical Name: Quinidine--56-54-2; References: 4; Journal Coden: JPMSAE; Section Heading: Drug Stability
N2 - A substance found in quinidine gluconate injection containing alpha-thioglycerol as a stabilizer has been identified as alpha-(6-methoxy-4-quinolyl)-5-(5,6-dihydroxy-3-thia-n-hexyl)-2-qui nuc lidine methanol. It is a product of anti-Markownikoff addition of thioglycerol to the vinyl group of quinidine.
KW - Quinidine--gluconate-;
KW - Thioglycerol--alpha--;
KW - Stability--quinidine--gluconate, injection, containing alpha-thioglycerol as stabilizer, quinidine transformation product isolated;
KW - Stabilizers--injections--alpha-thioglycerol, formation of quinidine transformation product;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0934&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Markarian, C. A.;
AU - Shinnick, T. L.;
T1 - Purser pharmacist mate: marine physicians' assistant
CT - Purser pharmacist mate: marine physicians' assistant
JO - Hospitals
JF - Hospitals
Y1 - 1969/06/16/
VL - 43
IS - Jun 16
SP - 140
EP - 143
AD - United States Public Health Service Hospital, Staten Island, New York
N1 - Accession Number: 7-0809; Language: English; Journal Coden: HOSIAJ; Section Heading: Pharmaceutical Education; Abstract Author: Hugh F. Kabat
N2 - An unique training program consisting of 9 months of intensive academic and practical training prepares a paramedical person who can be assigned to ships at sea and take patient histories, perform a physical examination and survey available medication prior to providing the physician with enough information for him to render intelligent assistance by radio. There are 660 instructional hours and 420 hours of practical experience in anatomy and physiology (100 hours), environmental health and preventive medicine (90 hours), medical and surgical conditions (285 hours), patient care (330 hours), pharmacology (95 hours), clinical laboratory (95 hours), disaster control (55 hours), and other subjects. Teachers include physicians, pharmacists, hospital staff, purser instructors and others.
KW - Education, pharmaceutical--purser pharmacist mate--marine physicians' assistant;
KW - Physicians--marine--assistant, purser pharmacist mate, education;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0809&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, J. E., Jr.;
AU - Arzell, L.;
AU - Kellogg, D. S., Jr.;
AU - Thayer, J. D.;
T1 - In vitro susceptibility of Neisseria gonorrhoeae to nine antimicrobial agents
CT - In vitro susceptibility of Neisseria gonorrhoeae to nine antimicrobial agents
JO - Appl. Microbiol.
JF - Appl. Microbiol.
Y1 - 1969/07/01/
VL - 18
IS - Jul
SP - 21
EP - 23
AD - Venereal Disease Research Laboratory, State and Community Services Division, National Communicable Disease Center, Health Services and Mental Health Administration, Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 7-1469; Language: English; References: 6; Journal Coden: APMBAY; Section Heading: Microbiology; Abstract Author: Irving S. Rossoff
N2 - Nine antibiotics were tested in vitro against 45 gonococcal strains from penicillin #OQ#OQtherapy failures.'' Means and ranges of minimum inhibitory concentrations are tabulated. Twenty-five percent of the isolates were susceptible to 0.012 mcg. of penicillin/ml. indicating the possibility of poor or inaccurate case histories, reinfection, or low dosage.
KW - Antibiotics--Neisseria gonorrhoeae--in vitro susceptibility, of gonococcal strains from penicillin therapy failures;
KW - Neisseria gonorrhoeae--susceptibility--in vitro, to antibiotics, of gonococcal strains from penicillin therapy failures;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1469&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Iverson, J. L.;
AU - Harrill, P. G.;
AU - Weik, R. W.;
T1 - Fatty acid composition of cocoa butter by urea fractionation and programmed temperature gas chromatography
CT - Fatty acid composition of cocoa butter by urea fractionation and programmed temperature gas chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/07/01/
VL - 52
IS - Jul
SP - 685
EP - 688
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4622; Language: English; Trade Name: Cocoa butter; Generic Name: Theobroma oil; References: 8; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - The object of this investigation was to detect and estimate the fatty acids present in trace amounts (less than 0.1%) in cocoa butter oil (theobroma oil). Based on the analysis of 6 cocoa butter oils, it would appear that these oils have a uniform fatty acid composition. The variation for palmitic acid is 25-29%, for stearic acid is 33-36%, and for oleic acid is 32-35%.
KW - Theobroma oil--analysis-;
KW - Acids--fatty--in theobroma oil, urea fractionation and gas chromatography;
KW - Analysis--acids--fatty, in theobroma oil, urea fractionation and gas chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4622&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Characterization of the steam nonvolatile residue of bergamot oil and some other essential oils
CT - Characterization of the steam nonvolatile residue of bergamot oil and some other essential oils
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/07/01/
VL - 52
IS - Jul
SP - 719
EP - 728
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 7-4819; Language: English; Chemical Name: Bergamot oil--8007-75-8 Lemon oil--8008-56-8; References: 20; Journal Coden: JANCA2; Section Heading: Pharmacognosy; Abstract Author: Douglas L. Thompson
N2 - Bergaptene and xanthotoxin were the only furocoumarin photosensitizers identified by a thin layer chromatographic procedure in the following oils: bergamot, lemon, lime, angelica seed, and angelica root.
KW - Bergamot oil--analysis-;
KW - Lemon oil--analysis-;
KW - Bergaptene--photosensitizer-;
KW - Xanthotoxin--photosensitizer-;
KW - Oils--lime--analysis, photosensitizing constituents, TLC;
KW - Oils--angelica--seed and root, photosensitizing constituents, analysis, TLC;
KW - Furocoumarins--constituents--photosensitizing, in essential oils, TLC;
KW - Oils--essential--photosensitizing constituents, bergaptene and xanthotoxin, TLC;
KW - Photosensitivity--bergaptene--and xanthotoxin, constituents identified in essential oils;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4819&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Roberts, L. A.;
T1 - Fluorometric determination of atropine and hyoscyamine in tablets and injections
CT - Fluorometric determination of atropine and hyoscyamine in tablets and injections
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/08/01/
VL - 58
IS - Aug
SP - 1015
EP - 1018
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, San Francisco, California 94102
N1 - Accession Number: 7-1447; Language: English; Chemical Name: Atropine--51-55-8 Hyoscyamine--101-31-5; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Atropine--and hyoscyamine-;
KW - Hyoscyamine--and atropine-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1447&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Myrick, J. W.;
T1 - Automated assay of single tablets of digoxin
CT - Automated assay of single tablets of digoxin
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/08/01/
VL - 58
IS - Aug
SP - 1018
EP - 1021
SN - 00223549
AD - U. S. Department of Health, Education and Welfare, Food and Drug Administration, Division of Pharmaceutical Sciences, National Center for Drug Analysis, St. Louis, Missouri 63101
N1 - Accession Number: 7-1710; Language: English; Chemical Name: Digoxin--20830-75-5; References: 12; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - An automated analytical system has been used to determine the amount of digoxin in single tablets at a level of 0.25 mg. per tablet. Relative standard deviation of the method was 0.7% for powdered tablet samples and 1.0% for an authentic tablet formulation. A schematic diagram, absorbance curves and tables are included.
KW - Digoxin--tablets-;
KW - Automation--digoxin--analysis, single tablets;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1710&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Woodson, R. D.;
AU - Clinton, J. J.;
T1 - Hepatitis prophylaxis abroad
CT - Hepatitis prophylaxis abroad
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1969/08/18/
VL - 209
IS - Aug 18
SP - 1053
EP - 1058
AD - National Communicable Disease Center, Health Services and Mental Health Administration, Public Health Service, Atlanta, Georgia
N1 - Accession Number: 7-0607; Language: English; References: 15; Journal Coden: JAMAAP; Section Heading: Drug Evaluations; Sociology, Economics and Ethics; Abstract Author: Dale E. Johnson
N2 - The effectiveness of immune serum globulin in protecting Peace Corps volunteers was studied. Peace Corps volunteers receive semi-annual injections of 0.05 ml. of immune serum globulin per pound of body weight. In 1965 and 1966, 191 cases of viral hepatitis were reported out of 19,622 volunteers. Ninety-three of these cases were studied concerning reported incidence by geographic area and relation of onset of hepatitis to time of immune serum globulin administration. After a nonstatistical analysis of the noncontrolled data, the authors suggest immune serum globulin should be administered in a dose of 0.05 ml. per pound of body weight at intervals not exceeding 4 months, and in areas of high incidence, immune serum globulin should be administered during the entire period of residence abroad.
KW - Globulins--immune serum--hepatitis prophylaxis in Peace Corps volunteers;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0607&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Patton, R. D.;
AU - Patten, E.;
AU - Stein, E.;
AU - Damato, A. N.;
T1 - Large doses of procainamide for paroxysmal ventricular tachycardia
CT - Large doses of procainamide for paroxysmal ventricular tachycardia
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1969/08/25/
VL - 209
IS - Aug 25
SP - 1221
EP - 1222
AD - Cardiopulmonary Laboratory, U. S. Public Health Service Hospital, Staten Island, New York
N1 - Accession Number: 7-0892; Language: English; Chemical Name: Procainamide--51-06-9; References: 9; Journal Coden: JAMAAP; Section Heading: Drug Evaluations; Abstract Author: Dale E. Johnson
N2 - Case reports of 4 patients with refractory ventricular tachycardia successfully treated with 7.5 to 10.5 g. of procainamide hydrochloride are presented. The authors comment that these maintenance dosage levels, although potentially toxic, should be considered before more radical therapy is utilized.
KW - Procainamide--hydrochloride-;
KW - Dosage--procainamide--hydrochloride, large doses, for paroxysmal ventricular tachycardia;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0892&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Advisory Committee on Immunization Practices;
T1 - Influenza: recommendations for immunization
CT - Influenza: recommendations for immunization
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1969/09/01/
VL - 71
IS - Sep
SP - 617
EP - 618
SN - 00034819
AD - United States Public Health Service, Washington, D. C.
N1 - Accession Number: 7-0655; Language: English; Journal Coden: AIMEAS; Section Heading: Pharmacology; Sociology, Economics and Ethics; Abstract Author: Judith A. Kepler
N2 - For 1969-1970, both standard and highly purified bivalent influenza vaccines will be available. The recommended adult dose will contain 400 chick cell agglutinating (CCA) units of Hong Kong strain antigen (A2/Aichi/2/68) and 300 CCA units of type B antigen (B/Mass/3/66). Recommendations for use, vaccination schedule and precautions are discussed.
KW - Influenza vaccines--bivalent-;
KW - Immunization--influenza--bivalent vaccines, recommendations for use;
KW - United States Public Health Service--Advisory Committee on Immunization Practices--influenza vaccines, bivalent, recommendations for use;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0655&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lambert, J. P. F.;
AU - Levander, O.;
AU - Argrett, L.;
AU - Simpson, R. E.;
T1 - Neutron activation analysis of selenium in biological samples
CT - Neutron activation analysis of selenium in biological samples
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/09/01/
VL - 52
IS - Sep
SP - 915
EP - 917
AD - Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4397; Language: English; Chemical Name: Selenium--7782-49-2; References: 8; Journal Coden: JANCA2; Section Heading: Drug Metabolism and Body Distribution
N2 - The selenium content in tissues of rats fed chronically toxic levels of selenium was determined by neutron activation analysis. The results were highly dependent on the value of the 77mSe half-life used in the computations. The best half-life value was selected by comparing results for different values of half-life with those from a colorimetric determination of identical samples. The neutron activation analysis method is rapid, nondestructive, and free of any chemical procedures. Selenium was determined at a 3 mcg. level with a counting error of 6% at the 95% confidence level.
KW - Selenium--analysis-;
KW - Toxicity studies--selenium--tissue levels, in rats;
KW - Tissue levels--selenium--in rats;
KW - Metabolism--selenium--tissue levels, in rats;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4397&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Moore, J. M.;
T1 - Polarographic assay of niacinamide in pharmaceutical preparations
CT - Polarographic assay of niacinamide in pharmaceutical preparations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/09/01/
VL - 58
IS - Sep
SP - 1117
EP - 1120
SN - 00223549
AD - Baltimore District Laboratories, Food and Drug Administration, 900 Madison Avenue, Baltimore, Maryland 21201
N1 - Accession Number: 7-1442; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Nicotinamide--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1442&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1971-09085-001
AN - 1971-09085-001
AU - Howell, M. A.
AU - Brumback, G. B.
AU - Newman, S. H.
T1 - Work attitudes and retention of engineers.
JF - Personnel Administration
JO - Personnel Administration
Y1 - 1969/09//
VL - 32
IS - 5
SP - 57
EP - 58
N1 - Accession Number: 1971-09085-001. Partial author list: First Author & Affiliation: Howell, M. A.; U.S. Public Health Service, Washington, D.C. Release Date: 19710501. Correction Date: 20151207. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Government; Job Satisfaction; Occupations. Minor Descriptor: Engineering. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Page Count: 2. Issue Publication Date: Sep, 1969.
AB - Describes the results of a survey of work attitudes of 423 Commissioned Officer Engineers in the United States Public Health Service which aimed to identify attitudes associated with staying in or leaving the health organization. The basic attitude dimensions underlying evaluations of various aspects of the employment situation were identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job turnover
KW - work attitudes
KW - engineers in U.S. Public Health Service
KW - 1969
KW - Attitudes
KW - Government
KW - Job Satisfaction
KW - Occupations
KW - Engineering
KW - 1969
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1971-09085-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Richardson, J. A.;
AU - Borchardt, K. A.;
T1 - Adverse effect on bacteria of peritoneal dialysis solutions that contain acetate
CT - Adverse effect on bacteria of peritoneal dialysis solutions that contain acetate
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1969/09/27/
VL - 3
IS - Sep 27
SP - 749
EP - 750
SN - 09598146
AD - Research Dialysis Center and Department of Pathology, Public Health Service Hospital, San Francisco, California 94118
N1 - Accession Number: 7-0883; Language: English; References: 12; Journal Coden: BMJOAE; Section Heading: Drug Evaluations; Microbiology; Abstract Author: Monte S. Cohon
N2 - Peritoneal dialysis solutions containing 43 meq./L. acetate had a much greater antibacterial effect against E. coli, S. aureus, or Pseudomonas species than lactate-containing dialysis solutions. Acetate-containing dialysis solutions may possibly provide a greater degree of protection for peritonitis.
KW - Dialysis--peritoneal--solutions, containing acetate, adverse effect on bacteria;
KW - Solutions--dialysis--peritoneal, containing acetate, adverse effect on bacteria;
KW - Acetates--containing peritoneal dialysis solutions--adverse effect on bacteria;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0883&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Natkin, Eugene
AU - Van Hassel, Henry J.
AU - Steiner, James C.
T1 - The Comparative Merits of Silver Cones and Gutta Percha in the treatment of Fine Canals of Molar Teeth.
JO - Journal of the British Endodontic Society
JF - Journal of the British Endodontic Society
Y1 - 1969/10//Oct-Dec1969
VL - 3
IS - 4
M3 - Article
SP - 59
EP - 61
SN - 00070653
AB - Looks into the advantages of the use of gutta percha for obturation of the fine canals of molar teeth. Ability of gutta percha to adequately obturate an irregularly shaped canal; Detection of failures of gutta percha cases; Comparison of the effectiveness of gutta percha with a silver cone in obturating fine canals.
KW - FILLINGS (Dentistry)
KW - GUTTA-percha
KW - TEETH
KW - CYCLIZED rubber
KW - DENTAL pulp cavity
KW - OPERATIVE dentistry
N1 - Accession Number: 17610438; Natkin, Eugene 1; Van Hassel, Henry J. 2,3; Steiner, James C. 3; Source Information: Oct-Dec1969, Vol. 3 Issue 4, p59; Subject: FILLINGS (Dentistry); Subject: GUTTA-percha; Subject: TEETH; Subject: CYCLIZED rubber; Subject: DENTAL pulp cavity; Subject: OPERATIVE dentistry; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17610438&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 84005397
T1 - Egor Scheffer--Russia's Hawaiian interloper.
AU - Arthaud, John B.
AU - Arthaud, J B
Y1 - 1969/10/02/
N1 - Accession Number: 84005397. Language: English. Entry Date: 19811231. Revision Date: 20161118. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - History
KW - Alaska
KW - Hawaii
KW - Military Medicine -- History
KW - Russia
KW - United States
KW - Scheffer, E N
SP - 778
EP - 780
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 281
IS - 14
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - * From the Alaska Native Medical Center, United States Public Health Service, Anchorage, Alaska (address reprint requests to Dr. Arthaud at Box 7–741, Alaska Native Medical Center, Anchorage, Alas., 99501).
U2 - PMID: 4897017.
DO - 10.1056/NEJM196910022811408
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=84005397&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Hopkins, C. C.;
AU - Dismukes, W. E.;
AU - Glick, T. H.;
AU - Warren, R. J.;
T1 - Surveillance of paralytic poliomyelitis in the United States. 1966 and 1967 cases, and 1965-1967 cases associated with oral poliovirus vaccine
CT - Surveillance of paralytic poliomyelitis in the United States. 1966 and 1967 cases, and 1965-1967 cases associated with oral poliovirus vaccine
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1969/10/27/
VL - 210
IS - Oct 27
SP - 694
EP - 700
AD - Epidemiology Program, National Communicable Disease Center, Public Health Service, Atlanta, Georgia
N1 - Accession Number: 7-1555; Language: English; References: 17; Journal Coden: JAMAAP; Section Heading: Toxicity; Sociology, Economics and EthicsDrug Evaluations
N2 - An epidemiological study on paralytic poliomyelitis in the United States is presented. In 1966, 103 cases of paralytic poliomyelitis were reported in the United States. An outbreak of 66 cases caused by type 1 poliovirus occurred in Texas, predominantly in unimmunized, preschool children. In 1967, 40 cases were reported, with 16 in southwestern border states. In both years, sporadic cases of poliomyelitis continued to occur in persons without known contact with either live oral poliovirus vaccine, or with other patients. During the three-year period 1965-1967, 8 cases of paralytic poliomyelitis occurred in recent recipients of oral poliovirus vaccine, while 16 additional cases were reported in persons with familial or other close contact with vaccine recipients. In view of the proven benefit of oral poliovirus vaccines, however, these cases present a minor public health problem.
KW - Polio vaccines--polio virus-;
KW - Toxicity studies--polio vaccines--polio virus, oral, association with paralytic poliomyelitis in U. S.;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1555&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brands, A. J.;
T1 - Significance of the task force report on prescription drugs for colleges and boards of pharmacy
CT - Significance of the task force report on prescription drugs for colleges and boards of pharmacy
JO - Am. J. Pharm.
JF - Am. J. Pharm.
Y1 - 1969/11/01/
VL - 141
IS - Nov-Dec
SP - 216
EP - 224
AD - Pharmacy Branch, Indian Health Service, Public Health Service, 7915 Eastern Ave., Silver Spring, Maryland 20910
N1 - Accession Number: 7-1520; Language: English; Journal Coden: AJPRAL; Section Heading: Pharmacy Practice; Abstract Author: William A. Zellmer
N2 - The author discusses recommendations of the Task Force on Prescription Drugs which relate to pharmacy education, legislation, the practice of pharmacy, and the drug prescribers. Carrying out these recommendations may involve changes in the practice of pharmacy, in pharmacy education, and in the state laws governing the practice of pharmacy.
KW - Task forces--prescription drugs--recommendations relating to pharmacy education, legislation, practice of pharmacy and drug prescribers discussed;
KW - Pharmacy--state boards--significance of task force report on prescription drugs;
KW - Education, pharmaceutical--Task Force on Prescription Drugs--recommendations, relating to pharmacy education, discussion;
KW - Legislation--Task Force on Prescription Drugs--recommendations, relating to legislation, discussion;
KW - Pharmacy--practice--Task Force on Prescription Drugs, recommendations, relating to practice of pharmacy, discussion;
KW - Prescriptions--Task Force on Prescription Drugs--recommendations, relating to drug prescribers, discussion;
KW - Physicians--Task Force on Prescription Drugs--recommendations, relating to drug prescribers, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1520&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Clevenger, W. L.;
T1 - Intensified drug inspection program: procedures and results
CT - Intensified drug inspection program: procedures and results
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1969/11/01/
VL - 23
IS - Nov-Dec
SP - 263
EP - 268
AD - Food and Drug Administration, New York District, Brooklyn, New York
N1 - Accession Number: 7-1498; Language: English; Journal Coden: BUYRAI; Section Heading: Legislation, Laws and Regulations
N2 - The objectives of the Food and Drug Administration's Intensified Drug Inspection Program (IDIP) are outlined. The program represents a major effort toward an effective blend of voluntary and regulatory compliance. The program has fostered better rapport and more effective dialogue between industry and the Food and Drug Administration.
KW - Food and Drug Administration (U.S.)--Intensified Drug Inspection Program--objectives, procedures and results;
KW - Control, quality--Intensified Drug Inspection Program--Food and Drug Administration's, objectives, procedures and results;
KW - Regulations--Food and Drug Administration (U.S.)--Intensified Drug Inspection Program, objectives, procedures and results;
KW - Drugs--inspection--Food and Drug Administration (U.S.), Intensified Drug Inspection Program, objectives, procedures and results;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1498&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gelber, R.;
AU - Jacobsen, P.;
AU - Levy, L.;
T1 - Study of the availability of six commercial formulations of isoniazid
CT - Study of the availability of six commercial formulations of isoniazid
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1969/11/01/
VL - 10
IS - Nov-Dec
SP - 841
EP - 848
SN - 00099236
AD - Public Health Service Hospital, San Francisco, California
N1 - Accession Number: 7-2279; Language: English; Chemical Name: Isoniazid--54-85-3; References: 10; Journal Coden: CLPTAT; Section Heading: Biopharmaceutics; Drug Evaluations
N2 - The systemic availability of 6 formulations of isoniazid (INH) were compared. Each of 6 subjects ingested approximately 10 mg. per kilogram each of 6 formulations of INH. Plasma samples obtained at 1/4, 1/2, 3/4, 1, 1 1/2, 2, 4, 6, and 8 hours after ingestion were analyzed for unmetabolized INH. In order to enable calculation of gastrointestinal absorption kinetics, subjects received an intravenous dose of isoniazid with subsequent INH plasma concentration determinations. Studies of tablet potency, disintegration time, and dissolution rate were also conducted and correlated with in vivo results. All tablets met U.S.P. standards for potency (100 7 mg.) and disintegration time (30 minutes), and all tablets dissolved rapidly. No significant differences were noted among formulations in mean peak INH concentrations (range 10.3 to 11.4 mcg. per ml.) or in the integral of INH concentration with respect to time between 1 and 8 hours (range 34.5 to 41.4 mcg.-hr./ml.). All tablets were essentially completely absorbed by one hour, and gastrointestinal absorption rate calculations demonstrated no consistent differences among the INH formulations studied. It was concluded that the INH preparations studied were therapeutically equivalent.
KW - Isoniazid--formulations-;
KW - Formulations--isoniazid--availability, systemic;
KW - Drugs--availability--isoniazid, six formulations, systemic;
KW - Equivalency--isoniazid--six formulations;
KW - Drugs--clinical effectiveness--isoniazid, six formulations;
KW - Blood levels--isoniazid--six formulations;
KW - Absorption--isoniazid--six formulations;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2279&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Iverson, J. L.;
T1 - Fatty acid composition of crude and refined cottonseed oils
CT - Fatty acid composition of crude and refined cottonseed oils
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/11/01/
VL - 52
IS - Nov
SP - 1148
EP - 1150
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4366; Language: English; Chemical Name: Cottonseed oil--8001-29-4; References: 22; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - The fatty acid composition of 20 cottonseed oils was determined by isothermal gas-liquid chromatography (GLC) analysis of the total esters. A urea fractionation procedure, combined with modified programmed temperature GLC, was used to detect esters present in trace amounts (0.001-0.1%) in 4 refined and 3 crude oils. The odd and even chain length saturated acids from C8 to C26 were present. Mono-unsaturated acids from C15 to C20 were also detected. The crude and refined oils did not differ markedly in their fatty acid composition. The presence of malvalic and sterculic acids and the possible presence of shorter and longer chain length cyclopropenoid acids with their interfering GLC peaks make it impossible to detect and quantitatively estimate the branched and multiple branched acids.
KW - Cottonseed oil--crude-;
KW - Acids--fatty--in crude and refined cottonseed oils;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4366&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wenninger, J. A.;
AU - Yates, R. L.;
T1 - Constituents of opoponax oil: sesquiterpene hydrocarbons
CT - Constituents of opoponax oil: sesquiterpene hydrocarbons
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/11/01/
VL - 52
IS - Nov
SP - 1155
EP - 1161
AD - Division of Color and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4367; Language: English; References: 27; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - This paper on the sesquiterpene hydrocarbons of opoponax oil is part of a continuing study of the composition of essential oils reportedly used in perfume oils. During the present study, trans-beta-ocimene was confirmed as the major monoterpenic hydrocarbon constituent and 15 additional sesquiterpene hydrocarbons were identified. Seven commercial samples of opoponax oil purchased from domestic sources were investigated. By gas chromatography (GLC), 6 of these were found to be qualitatively identical to an authentic sample of opoponax oil. One commercial sample contained appreciable quantities of diethylphthalate and sesquiterpene hydrocarbons common to American cedarwood oil. The major products obtained when hydrocarbons are regenerated from bisabolene trihydrochloride, using sodium acetate and acetic acid as reagents, were also characterized and identified as cis-alpha-bisabolene and beta-bisabolene.
KW - Ocimene--trans-beta--;
KW - Oils--opoponax--analysis, monoterpenic and sesquiterpene hydrocarbon constituents;
KW - Opoponax oils--analysis--monoterpenic and sesquiterpene hydrocarbon constituents;
KW - Sesquiterpenes--constituents--opoponax oil, analysis;
KW - Hydrocarbons--sesquiterpenes--and monoterpenes, in opoponax oil, analysis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4367&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Howard, J. W.;
AU - Fazio, T.;
AU - Williams, B. K.;
AU - White, R. H.;
T1 - Determination of dicyclohexylamine in cyclamates
CT - Determination of dicyclohexylamine in cyclamates
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/11/01/
VL - 52
IS - Nov
SP - 1195
EP - 1199
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4385; Language: English; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - This paper describes a procedure for dicyclohexylamine analysis in which extraction techniques were used to isolate the compound and gas liquid chromatography was utilized as the determinative method. Confirmation of the identity of the amine was achieved by mass spectrometry or by formation of the hydrochloride for IR spectrophotometry.
KW - Dicyclohexylamine--analysis-;
KW - Cyclamates--analysis--for dicyclohexylamine;
KW - Analysis--cyclamates--for dicyclohexylamine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Alber, L. L.;
T1 - All-purpose gas-liquid chromatographic column for pharmaceuticals
CT - All-purpose gas-liquid chromatographic column for pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1969/11/01/
VL - 52
IS - Nov
SP - 1295
EP - 1300
AD - Food and Drug Administration, 433 W. Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 7-4369; Language: English; References: 11; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - A 6 foot column containing 3% OV-17 methylphenyl polysiloxane on gas chrom Q was evaluated as a universal GLC column for pharmaceuticals. With isothermal column temperatures ranging from 50 to 300DGC., the following have been chromatographed: alcohols, anesthetics, anticholinergics, antihistamines, antiseptics, barbiturates, sterols, steroids, sulfonamides, sympathomimetics, and xanthine alkaloids.
KW - Analysis--drugs--chromatography, gas, universal GLC column;
KW - Chromatography, gas--drugs--universal GLC column;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4369&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bowman, F. W.;
T1 - Sterility testing of pharmaceuticals
CT - Sterility testing of pharmaceuticals
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/11/01/
VL - 58
IS - Nov
SP - 1301
EP - 1308
SN - 00223549
AD - Division of Pharmaceutical Sciences, National Center for Antibiotics and Insulin Analysis, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 7-1296; Language: English; References: 57; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Technology; Abstract Author: D. R. Tousignaut
N2 - A review of sterility testing is presented and the U.S. official compendia standards emphasized. Specifically discussed are: principles of sterility testing; sampling procedures; culture media; time and temperature of incubation; biological indicators; environmental conditions; and methods for sterility testing.
KW - Sterility--tests--review;
KW - Tests--sterility--review;
KW - Pharmacopeial standards--sterility--tests;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1296&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gordon, J. B.;
T1 - Politics of community Medicine projects
CT - Politics of community Medicine projects
JO - Medical Care (USA)
JF - Medical Care (USA)
Y1 - 1969/11/01/
VL - 7
IS - Nov-Dec
SP - 419
EP - 428
SN - 00257079
AD - Public Health Service, National Institutes of Health, Room 2A32, 9000 Rockville Pike, Bethesda, Maryland 20014
N1 - Accession Number: 7-3327; Language: English; References: 32; Journal Coden: MDLCBD; Section Heading: Sociology, Economics and Ethics
N2 - The community health center is a new institution which has been promoted by the Office of Economic Opportunity to provide health service to the poor, to establish an alternate model for medical practice, and to help reintegrate the poor into the mainstream of society. Among the barriers to the success of this innovation has been a lack of political realism on the part of many of the participants. A sociological analysis of the process of project evolution demonstrating the many opportunities for controversy and conflict to develop, is presented. Inferences from conflict theory are presented to show how a sophisticated approach to controversy can expedite social change. If health professionals, including pharmacists, are to be involved in the wide range of social and physical ills of their patients they must be familiar with these strategies.
KW - Sociology--health care--centers, community participants lack political realism;
KW - Pharmacists--health care--centers, community need for political realism if center to succeed;
KW - Health care--centers--community, success dependent upon political realism by participants;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3327&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Patton, R. D.;
AU - Kenamore, B.;
AU - Stein, E.;
T1 - Antibiotic prophylaxis for temporary transvenous pacemakers
CT - Antibiotic prophylaxis for temporary transvenous pacemakers
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1969/11/13/
VL - 281
IS - Nov 13
SP - 1106
EP - 1108
SN - 00284793
AD - reprint: United States Public Health Service Hospital, Staten Island, New York 10304
N1 - Accession Number: 7-3657; Language: English; Chemical Name: Dicloxacillin--3116-76-5 Bacitracin--1405-87-4 Methicillin--61-32-5; References: 14; Journal Coden: NEJMAG; Section Heading: Drug Evaluations; Abstract Author: Thomas Grande
N2 - A study of 3 groups of patients was undertaken to evaluate the efficacy of antibiotic prophylaxis in patients with indwelling temporary intracardiac catheters. Patients were divided into 3 groups: (1) those receiving antibiotics for pre-existing infection at time of insertion of the catheter; (2) an antibiotic prophylaxis group; and (3) a control group. Bacitracin ointment was applied to the site of insertion after each daily change of dressing. Patients in the antibiotic group received methicillin, 1 g. I.M. or I.V. every 6 hours for 48 hours, and then 500 mg. of dicloxacillin by mouth every 6 hours until the catheter was removed. Analysis of the control and antibiotic prophylaxis group revealed one case of sepsis and 3 of noteworthy infection in a series of 46 patients. It appears that antibiotic prophylaxis was of little protective value while the application of bacitracin ointment appears useful in reducing sepsis.
KW - Dicloxacillin--prophylaxis-;
KW - Bacitracin--ointment-;
KW - Methicillin--prophylaxis-;
KW - Antibiotics--prophylaxis--efficacy evaluated in patients with indwelling heart catheters;
KW - Catheters--cardiac--infections, at site of insertion, antibiotic prophylaxis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3657&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sarosi, G. A.;
AU - Parker, J. D.;
AU - Doto, I. L.;
AU - Tosh, F. E.;
T1 - Amphotericin B in cryptococcal meningitis. Long-term results of treatment
CT - Amphotericin B in cryptococcal meningitis. Long-term results of treatment
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1969/12/01/
VL - 71
IS - Dec
SP - 1079
EP - 1087
SN - 00034819
AD - Ecological Investigations Program, National Communicable Disease Center, Health Services and Mental Health administration, Public Health Service, U. S. Department of Health, Education and Welfare, Kansas City, Kansas
N1 - Accession Number: 7-1355; Language: English; Chemical Name: Amphotericin B--1397-89-3; References: 24; Journal Coden: AIMEAS; Section Heading: Drug Evaluations
N2 - Thirty-one patients with proved cryptococcal meningitis were treated with intravenous amphotericin B, and almost half had intrathecal therapy as well. The case fatality ratio during initial treatment was 9 of 31, or 29%. Outcome of the initial therapy tended to be worse, although not significantly so, in those patients who were older and had coexisting disease. Four of the 22 surviving patients relapsed from 6 weeks to 29 months after the completion of initial therapy. Three of the 4 patients who relapsed died from cryptococcal meningitis in spite of a second course of therapy. Two additional patients, apparently cured of cryptococcal meningitis, died of other causes shortly after the completion of initial therapy. The remaining 17 patients have now been followed from 2 to 12 years (average 7 1/2 years). Only 4 have significant neurological residuals, but none require custodial care. Frequent follow-up examinations, including examinations of the spinal fluid, are recommended for at least 3 years to recognize all relapses early. This study is in agreement with other reports supporting the effectiveness of amphotericin B in the treatment of cryptococcal meningitis.
KW - Amphotericin B--meningitis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-1355&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazzari, F. R.;
AU - Rigglemen, O. H.;
T1 - Polarographic determination of oxazepam
CT - Polarographic determination of oxazepam
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/12/01/
VL - 58
IS - Dec
SP - 1530
EP - 1531
SN - 00223549
AD - Division of Pharmaceutical Sciences, Food and Drug Administration, Department of Health, Education and Welfare, Washington, D. C. 20204
N1 - Accession Number: 7-2820; Language: English; Chemical Name: Oxazepam--604-75-1; References: 2; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Oxazepam was extracted from a capsule dosage form and polarographed in a methanol-methylene chloride solvent system. The method is rapid and reasonably specific. Recoveries ranged from 97.0-104.0% with an average of 99.9%.
KW - Oxazepam--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2820&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rader, B. R.;
T1 - Chromatographic analysis of chlorpheniramine, pyrilamine, and methapyrilene in combination
CT - Chromatographic analysis of chlorpheniramine, pyrilamine, and methapyrilene in combination
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1969/12/01/
VL - 58
IS - Dec
SP - 1535
EP - 1536
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Los Angeles, California 90015
N1 - Accession Number: 7-2821; Language: English; Chemical Name: Chlorpheniramine--132-22-9 Pyrilamine--91-84-9 Methapyrilene--91-80-5; References: 8; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - A partition chromatographic method is presented for the separation and quantitation of chlorpheniramine, methapyrilene, and pyrilamine in combination. Six commercial samples and 2 synthetic samples were analyzed. Recoveries ranged from 95-106% of declared for the commercial drug preparations and from 96-103% for the synthetic preparations.
KW - Chlorpheniramine--combination, pyrilamine, methapyrilene-;
KW - Pyrilamine--combination, methapyrilene, chlorpheniramine-;
KW - Methapyrilene--combination, chlorpheniramine, pyrilamine-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-2821&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Thin layer chromatography and ultraviolet spectrophotometry of sulfonamide mixtures. A study of the absolute recoveries
CT - Thin layer chromatography and ultraviolet spectrophotometry of sulfonamide mixtures. A study of the absolute recoveries
JO - J. Chromatogr.
JF - J. Chromatogr.
Y1 - 1969/12/23/
VL - 45
IS - Dec 23
SP - 421
EP - 431
AD - Food and Drug Administration, Philadelphia District, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 7-3955; Language: English; References: 21; Journal Coden: JOCRAM; Section Heading: Drug Analysis
N2 - Recovery patterns were studied for individual sulfonamides separated from a mixture by TLC and then determined by UV spectrophotometry. To make the investigation more complete experimental conditions such as quantity of sulfonamide per spot, extracting solvent and path length were varied. The recoveries are never complete, but fairly constant. Factors affecting recoveries and accuracy of results are discussed.
KW - Sulfonamides--analysis--mixtures, TLC and UV spectrophotometry, study of absolute recoveries;
KW - Mixtures--sulfonamides--analysis, TLC and UV spectrophotometry, study of absolute recoveries;
KW - Analysis--sulfonamides--mixtures, TLC and UV spectrophotometry, study of absolute recoveries;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3955&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
T1 - Stability of color additives: FD&C Red No. 2 in baked goods
CT - Stability of color additives: FD&C Red No. 2 in baked goods
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 23
EP - 25
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-0454; Language: English; Trade Name: FD&C Red No. 2; Generic Name: Amaranth; Chemical Name: Amaranth--915-67-3; References: 7; Publication Type: Color Additives; Journal Coden: JANCA2; Section Heading: Drug Stability
N2 - Data are presented which show that FD&C Red No. 2 (amaranth) decomposes when baked in cookies; one of the decomposition products is naphthionic acid. The data indicate that the color is reduced at the azo linkage, yielding naphthionic acid and 1-amino-2-naphthol-3,6-disulfonic acid (amino R-salt). However, neither 1-amino-2-naphthol-3,6-disulfonic acid nor the corresponding naphthoquinone could be isolated from baked goods, possibly because they react with sucrose or dextrose. The amount of decomposition of FD&C Red No. 2 can be calculated from the naphthionic acid content as determined fluorometrically.
KW - Amaranth--stability-;
KW - Naphthionic acid--amaranth decomposition product-;
KW - Stability--amaranth--in baked goods;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0454&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Korte, D. E.;
T1 - Collaborative study on determination of extractables from rubber materials
CT - Collaborative study on determination of extractables from rubber materials
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 43
AD - Food and Drug Administration, 240 Hennepin Avenue, Minneapolis, Minnesota 55401
N1 - Accession Number: 7-0823; Language: English; Chemical Name: Rubber--9006-04-6; References: 2; Publication Type: Food Additives; Journal Coden: JANCA2; Section Heading: Institutional Pharmacy Practice
N2 - Six laboratories studied a method for determining the amounts of water- and hexane-soluble materials in rubber. Four different samples, consisting of small disks of slab rubber, were extracted 7 hours with hexane or water. After the solvent was evaporated, the residues were determined gravimetrically. Satisfactory precision was obtained and it is recommended that the method be adopted as official first action.
KW - Rubber--additives-;
KW - Analysis--rubber--water- and hexane-soluble materials;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-0823&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Champion, M. H.;
T1 - Collaborative study on the GLC determination of propylene glycol in cosmetics
CT - Collaborative study on the GLC determination of propylene glycol in cosmetics
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 82
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-0543; Language: English; Chemical Name: Propylene glycol--57-55-6; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method for the determination of propylene glycol in cosmetics by GLC, using Chromosorb 101 as a column packing, was submitted to collaborative study. Four samples were analyzed at 2 levels of concentration. Results for the 6 collaborators show recoveries of 95-108% for samples containing from 20.0 to 40.0 mg. propylene glycol. The standard deviation varied from 0.54 to 1.67 and the coefficient of variance from 2.8 to 4.7%. It is recommended that the method be adopted as official first action.
KW - Propylene glycol--analysis-;
KW - Cosmetics--analysis--GLC, for propylene glycol content;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wells, C. E.;
T1 - Gas-liquid chromatography (GLC) determination of the optical isomers of amphetamine
CT - Gas-liquid chromatography (GLC) determination of the optical isomers of amphetamine
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 113
EP - 115
AD - Division of Pharmaceutical Sciences, National Center for Drug Analysis, Food and Drug Administration, St. Louis, Missouri 63101
N1 - Accession Number: 7-0732; Language: English; Trade Name: Amphetamine; Generic Name: Dextroamphetamine; Chemical Name: Dextroamphetamine--51-64-9 Amphetamine--300-62-9; References: 4; Publication Type: Drugs; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method is described for the quantitative determination of the ratio of (+)- (dextroamphetamine) and (-)-amphetamine stereoisomers by GLC. A derivative formed with N-trifluoroacetyl-(-)-prolyl chloride is chromatographed and the isomeric ratio is read from a standard calibration curve. The method is applicable to crystalline salts of amphetamine and to commercial tablet dosage forms. It is recommended that this method be subjected to collaborative study.
KW - Dextroamphetamine--stereoisomer-;
KW - Amphetamine--stereoisomers-;
KW - Stereoisomers--amphetamines--analysis, GLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, D. J.;
T1 - Ion exchange method for phenylpropanolamine hydrochloride in an elixir
CT - Ion exchange method for phenylpropanolamine hydrochloride in an elixir
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 116
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 7-0733; Language: English; Chemical Name: Phenylpropanolamine--14838-15-4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Phenylpropanolamine is retained on a sulfonated polystyrene cation exchange resin by the positive charge located in the cationic center of the molecule. The drug is eluted from the column with 0.27N HCl and determined by UV absorption. Duplicate recoveries were 101 and 101%. The method is recommended for collaborative study.
KW - Phenylpropanolamine--hydrochloride-;
KW - Elixirs--phenylpropanolamine--hydrochloride, ion exchange method of analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Roberts, L. A.;
T1 - Fluorometric determination of quinacrine hydrochloride in drug preparations: collaborative study
CT - Fluorometric determination of quinacrine hydrochloride in drug preparations: collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 117
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 7-0734; Language: English; Chemical Name: Quinacrine--83-89-6; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A fluorometric method has been developed for the quantitative and qualitative determination of quinacrine hydrochloride in drug preparations. The method consists of a preliminary dispersion of the sample in dilute HCl, filtration if necessary, appropriate dilutions of the sample to a final concentration of 0.5 mcg. quinacrine HCl/ml. in 0.1N HCl, and finally measurement of its fluorescence on a suitable spectrophotofluorometer. Nine collaborators obtained 100-102% recovery of quinacrine HCl and the fluorometric determination of quinacrine HCl is recommended as official first action.
KW - Quinacrine--hydrochloride-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
T1 - Collaborative study of the ion-pair column partition method for the determination of phenylephrine HCl in drug formulations
CT - Collaborative study of the ion-pair column partition method for the determination of phenylephrine HCl in drug formulations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/01/01/
VL - 53
IS - Jan
SP - 120
EP - 122
AD - National Center for Antibiotics and Insulin Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-0735; Language: English; Chemical Name: Phenylephrine--59-42-7; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Three solutions containing varying amounts of phenylephrine HCl were subjected to a collaborative evaluation of the ion-pair column partition method of Levine and Doyle. Results submitted by 20 collaborators were evaluated statistically. Recoveries averaged 99.0, 100.8, and 103.5% with 95% confidence limits of the mean of 0.71, 0.53, and 0.85%, respectively. The method is recommended for adoption as official first action. The colorimetric method approved in 1969 was recommended for adoption as official final action.
KW - Phenylephrine--hydrochloride-;
KW - Association of Official Analytical Chemists--phenylephrine--hydrochloride, method of analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1970-17800-001
AN - 1970-17800-001
AU - Salvatore, Santo
T1 - Interaction of sensory input, observation time, and moderate blood alcohol levels in determining vehicular velocity judgments.
JF - Proceedings of the Annual Convention of the American Psychological Association
JO - Proceedings of the Annual Convention of the American Psychological Association
Y1 - 1970///
VL - 5
IS - Pt. 1
SP - 5
EP - 6
CY - US
PB - American Psychological Association
N1 - Accession Number: 1970-17800-001. Partial author list: First Author & Affiliation: Salvatore, Santo; U.S. Public Health Service, Providence, R.I. Release Date: 19701101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blood; Motion Perception; Perception; Perceptual Motor Processes; Time. Classification: Human Experimental Psychology (2300). Population: Human (10). Page Count: 2. Issue Publication Date: 1970.
AB - All the variables under study velocity, observation time, sensory input, alcohol, and mode of observation influenced velocity estimates significantly. Strong sequence effects were also found to raise estimates following a low speed and lower estimates following a high speed. Sequence effects were inversely proportional to observation time. Expected peripheral visual estimates higher than frontal visual estimates were obtained under adverse sequence effects. Auditory stimulation provided more effective cuing to velocity than visual stimulation but was less effective than audiovisual input. Given audiovisual input normal Ss utilized visual cues and intoxicated Ss auditory cues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vehicular velocity judgments
KW - sensory input & observation time & moderate blood alcohol levels
KW - 1970
KW - Blood
KW - Motion Perception
KW - Perception
KW - Perceptual Motor Processes
KW - Time
KW - 1970
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Woodson, A. L.;
AU - Smith, D. E.;
T1 - Direct current and alternating current polarographic response of some pharmaceuticals in an aprotic organic solvent system
CT - Direct current and alternating current polarographic response of some pharmaceuticals in an aprotic organic solvent system
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1970/02/01/
VL - 42
IS - Feb
SP - 242
EP - 248
AD - Food and Drug Administration, Chicago District Laboratory, Room 1222, Post Office Building, Chicago, Illinois 60607
N1 - Accession Number: 7-2546; Language: English; References: 36; Journal Coden: ANCHAM; Section Heading: Pharmaceutics; Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - The results of a survey of dc and ac polarographic behavior of a variety of pharmaceutically important molecules in a representative aprotic solvent system, acetonitrile-tetrabutylammonium perchlorate, are presented. Of primary concern is the presentation of data which demonstrate in an effective manner the sensitivity and scope of aprotic solvent electrochemistry for the analysis of pharmaceuticals. Although the consideration of analytical routines for specific sample preparations is not of paramount interest in this article the data presented have been applied as guidelines to the successful development of assay procedures for certain commercial pharmaceutical preparations.
KW - Polarography--direct and alternating current--use in analyzing drugs in an aprotic solvent system;
KW - Analysis--polarography--direct and alternating current, use in drug analysis in an aprotic solvent system;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
T1 - The Immune Response in the Hamster II. STUDIES ON IgM.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 223
EP - 236
SN - 00192805
AB - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN M
KW - IMMUNE response
KW - ANTIGENIC determinants
KW - HAMSTERS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGICAL adjuvants
N1 - Accession Number: 13358132; Coe, J.E. 1; Source Information: Feb70, Vol. 18 Issue 2, p223; Subject: IMMUNOGLOBULIN M; Subject: IMMUNE response; Subject: ANTIGENIC determinants; Subject: HAMSTERS; Subject: IMMUNOGLOBULINS; Subject: IMMUNOLOGICAL adjuvants; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Bischoff, K. B.;
AU - Dedrick, R. L.;
AU - Zaharko, D. S.;
T1 - Preliminary model for methotrexate pharmacokinetics
CT - Preliminary model for methotrexate pharmacokinetics
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/02/01/
VL - 59
IS - Feb
SP - 149
EP - 154
SN - 00223549
AD - National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 7-3297; Language: English; Chemical Name: Methotrexate--59-05-2; References: 13; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2 - A pharmacokinetic model is presented to describe the distribution of methotrexate in mice, and the required physicochemical, anatomical, and physiological data are discussed. Methotrexate is excreted in the urine and bile; partial reabsorption occurs in the gastrointestinal tract. Observed bile concentrations were 300 times those of plasma. Models are illustrated.
KW - Methotrexate--body distribution-;
KW - Pharmacokinetics--methotrexate--body distribution, in mice, model presented;
KW - Drugs, body distribution--methotrexate--pharmacokinetic model to describe body distribution, in mice;
KW - Excretion--methotrexate--in urine and bile, partial reabsorption in gastrointestinal tract, in mice;
KW - Models--methotrexate--body distribution, in mice;
KW - Metabolism--methotrexate--body distribution and excretion, in mice;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wojtowicz, E. J.;
T1 - Column chromatographic method for the determination of sulfanilamide in pharmaceutical preparations containing sulfacetamide or its sodium salt
CT - Column chromatographic method for the determination of sulfanilamide in pharmaceutical preparations containing sulfacetamide or its sodium salt
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/02/01/
VL - 59
IS - Feb
SP - 240
EP - 241
SN - 00223549
AD - Food and Drug Administration, Buffalo, New York 14202
N1 - Accession Number: 7-3497; Language: English; Chemical Name: Sulfanilamide--63-74-1 Sulfacetamide--144-80-9; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Sulfanilamide--analysis-;
KW - Sulfacetamide--or sodium salt-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Meyers, E. L.;
T1 - Parenteral radiopharmaceuticals
CT - Parenteral radiopharmaceuticals
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1970/03/01/
VL - 24
IS - Mar-Apr
SP - 76
EP - 82
AD - Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 7-2662; Language: English; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - Radiopharmaceuticals should be handled in a similar manner to other drugs and radiation only constitutes an additional hazard. Information from preclinical studies and from clinical tests generally follow the pattern of other drugs. Quality assurance in the production and processing of radiopharmaceuticals is the result of many interrelated factors, beginning with the location of operation areas. With the advent of short-lived isotopes, the manufacturing control procedures from accelerator reactor to patients have become critical research problems, as time is of essence and the usual synthesis procedures have to be modified. Modification of conventional testing for pyrogens and sterility is necessary.
KW - Radiopharmaceuticals--injections--discussion;
KW - Injections--radiopharmaceuticals--discussion;
KW - Control, quality--radiopharmaceuticals--injections;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lakata, G. D.;
T1 - Methods evaluation in the chemical analysis of drugs in animal tissues
CT - Methods evaluation in the chemical analysis of drugs in animal tissues
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 224
EP - 226
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2348; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The methods used by the Food and Drug Administration (FDA) for evaluating analytical procedures used in determining drug residues in animal tissues are discussed. Some of the problems encountered in analyzing animal tissues for drug residues are also noted.
KW - Analysis--drug residues--in animal tissues, methods for evaluating analytical procedures;
KW - Drugs--residues--in animal tissues, methods for evaluating analytical procedures;
KW - Food and Drug Administration (U.S.)--analysis--methods for evaluating procedures used to determine drug residues in animal tissues;
KW - Drugs, body distribution--tissue residues--animal, methods for evaluating analytical procedures;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brunner, C. A.;
AU - Kunze, F. M.;
T1 - Analysis of mestranol in combination with norethindrone or norethynodrel by partition chromatography and UV measurement
CT - Analysis of mestranol in combination with norethindrone or norethynodrel by partition chromatography and UV measurement
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 234
EP - 237
AD - Division of Pharmaceutical Sciences, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2349; Language: English; Chemical Name: Mestranol--72-33-3 Norethindrone--68-22-4 Norethynodrel--68-23-5; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method is described for the analysis of tablets containing mestranol, or mestranol in combination with norethindrone or norethynodrel. Mestranol is isolated by column partition chromatography with formamide and dimethylformamide as the stationary phase and heptane as the mobile phase and determined by UV spectroscopy. The partition system used does not separate mestranol from ethynodiol diacetate nor chlormadinone acetate and is, therefore, not applicable to formulations in which these are present. It was concluded that the method was applicable to different brands of tablets and to tablets of uncertain age and that it was less time consuming than the methods currently being used.
KW - Mestranol--alone or in combination with norethindrone or norethynodrel-;
KW - Norethindrone--combination, mestranol-;
KW - Norethynodrel--combination, mestranol-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stein, C.;
T1 - Determination of 2-((2-hydroxy-1-naphthyl))azo -6-naphthalenesulfonic acid in D&C Red Nos. 10, 11, 12, and 13
CT - Determination of 2-((2-hydroxy-1-naphthyl))azo -6-naphthalenesulfonic acid in D&C Red Nos. 10, 11, 12, and 13
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 240
EP - 241
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2595; Language: English; Trade Name: Bronner's color; Generic Name: Naphthalenesulfonic acid; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Pharmaceutical TechnologyPharmaceutics
N2 - A thin layer chromatographic procedure is presented by which 2-((2-hydroxy-1-naphthyl))azo -6-naphthalenesulfonic acid (Bronner's color) is separated from D&C Red Nos. 10, 11, 12, and 13. Bronner's color is dissolved from the silica gel G adsorbent and determined spectrophotometrically. Recoveries of 0.25-10.02% added color averaged 91%. The Bronner's color content of commercial samples of colors analyzed by this procedure ranged from 0 to 2.6%.
KW - Naphthalenesulfonic acid--2-((2-hydroxy-1-naphthyl))azo -6--;
KW - Dyes--D&C Red Nos. 10, 11, 12, and 13--analysis for Bronner's color;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hobin, N. K.;
T1 - Turbidimetric determination of soluble sulfates in water-soluble color additives
CT - Turbidimetric determination of soluble sulfates in water-soluble color additives
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 242
EP - 244
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2334; Language: English; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
KW - Dyes--water-soluble--turbidimetric procedure for determining soluble sulfates;
KW - Sulfates--soluble--analysis, turbidimetric, in water-soluble dyes;
KW - Analysis--sulfates--soluble, turbidimetric procedure for determination in water-soluble dyes;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
T1 - Determination of 5,7"-disulfo-3,3" -dioxo-DELTA2,2"-biindoline, disodium salt, and 5-sulfo-3,3" -dioxo-DELTA2,2"-biindoline, sodium salt, in FD&C Blue No. 2
CT - Determination of 5,7"-disulfo-3,3" -dioxo-DELTA2,2"-biindoline, disodium salt, and 5-sulfo-3,3" -dioxo-DELTA2,2"-biindoline, sodium salt, in FD&C Blue No. 2
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 250
EP - 251
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2352; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - FD&C Blue No. 2--analysis-;
KW - Biindoline--constituents-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, D. J.;
T1 - Determination of ethylene oxide and ethylene chlorohydrin in plastic and rubber surgical equipment sterilized with ethylene oxide
CT - Determination of ethylene oxide and ethylene chlorohydrin in plastic and rubber surgical equipment sterilized with ethylene oxide
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/03/01/
VL - 53
IS - Mar
SP - 263
EP - 267
AD - Food and Drug Administration, 1560 E. Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 7-2212; Language: English; Chemical Name: Ethylene oxide--75-21-8 Ethylene chlorohydrin--107-07-3; References: 7; Journal Coden: JANCA2; Section Heading: Pharmaceutical Technology; Abstract Author: Douglas L. Thompson
N2 - A method is presented for the determination of ethylene chlorohydrin and ethylene oxide residues in plastic and rubber surgical equipment. The lower detection limit is approximately 25 ng. Recoveries of 3.5-50 ppm. chlorohydrin from 20-35 g. samples range from 64 to 100%, depending on the absorbing capacity of the material being analyzed and the condition of the adsorbent. The analysis of heart catheters (Gensini type) sterilized with ethylene oxide showed the presence of small amounts of ethylene chlorohydrin (approximately 2 or 3 ppm.). Adverse reactions have been reported for this type of catheter. No ethylene chlorohydrin was detected in the analysis of a heart catheter of the Cournand type, for which no adverse reactions have been reported. These analytical results suggest a correlation between the presence of ethylene chlorohydrin and adverse reactions to the heart catheters. No ethylene oxide was detected in samples of surgeons' rubber gloves; however, all samples showed the presence of ethylene chlorohydrin (1.5-10 ppm.). This data suggests that ethylene chlorohydrin is the more persistent of the 2 residues and degassing procedures should be devised accordingly.
KW - Ethylene oxide--analysis-;
KW - Ethylene chlorohydrin--analysis-;
KW - Toxicity--ethylene chlorohydrin--residues, in plastic and rubber surgical materials;
KW - Surgical supplies--sterilization--ethylene oxide, adverse reaction due to ethylene chlorohydrin residues;
KW - Sterilization--ethylene oxide--degassing procedures should remove ethylene chlorohydrin residues;
KW - Catheters--heart--adverse reactions, due to ethylene chlorohydrin residues;
KW - Gloves--rubber--surgeons, adverse reactions, due to ethylene chlorohydrin residues;
KW - Analysis--surgical supplies--plastics, and rubber, for ethylene oxide and ethylene chlorohydrin residues;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hall, R.;
T1 - Copper containers for food and drink
CT - Copper containers for food and drink
JO - Natl. Clearinghouse Poison Contr. Cent. Bull.
JF - Natl. Clearinghouse Poison Contr. Cent. Bull.
Y1 - 1970/03/01/
VL - Page
IS - Mar-Apr
SP - 1
EP - 7
AD - National Clearinghouse for Poison Control Centers, U.S. Department of Health, Education, and Welfare, Public Health Service, Washington, D. C. 20201
N1 - Accession Number: 7-1988; Language: English; Chemical Name: Copper--7440-50-8; References: 7; Journal Coden: NCPBBY; Section Heading: Toxicity; Abstract Author: A. Leon Moore
N2 - The author presents a summary of the acute and chronic toxic effects of the soluble copper salts. This includes case reports, clinical and pathological findings in copper sulfate toxicity, and a table of copper levels in serum and whole blood after the ingestion of various quantities of copper sulfate. The safety of copper and brass pipes and fittings in drinking water systems (pH above 5) is emphasized.
KW - Copper--toxicity-;
KW - Toxicity--copper--soluble salts, acute and chronic toxicity;
KW - Containers--copper--safety;
KW - Toxicity, environmental--water--drinking, safety of copper and brass piping systems;
KW - Blood levels--copper--after ingestion of copper sulfate;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 84005688
T1 - Detection of growth-hormone deficiency.
AU - Mitchell, M. L.
AU - Byrne, M. J.
AU - Sanchez, Y.
AU - Sawin, C. T.
Y1 - 1970/03/05/
N1 - Accession Number: 84005688. Language: English. Entry Date: 20161118. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Human Growth Hormone -- Blood
KW - Hypopituitarism -- Diagnosis
KW - Glucagon -- Administration and Dosage
KW - Injections, Intramuscular
KW - Hypopituitarism -- Blood
KW - Pituitary Diseases -- Blood
KW - Injections, Subcutaneous
KW - Chemical and Pharmacologic Phenomena
KW - Male
KW - Female
KW - Radioimmunoassay
KW - Time Factors
SP - 539
EP - 541
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 282
IS - 10
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Supported by a research grant (AM-12640) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, and by Part I Research Funds from the Veterans Administration Medical Research and Education Service, Veterans Administration Central Office, Washington, D.C.
U2 - PMID: 5413105.
DO - 10.1056/NEJM197003052821005
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Wise, G. R.;
T1 - Vasopressor-drug therapy for complications of cerebral arteriography
CT - Vasopressor-drug therapy for complications of cerebral arteriography
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1970/03/12/
VL - 282
IS - Mar 12
SP - 610
EP - 612
SN - 00284793
AD - Department of Medicine (Neurology), United States Public Health Service, University of Washington, Seattle, Washington
AD - reprints: Division of Neurology, Ohio State University Hospitals, 410 W. Tenth Avenue, Columbus, Ohio 43210
N1 - Accession Number: 7-3703; Language: English; References: 15; Journal Coden: NEJMAG; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Lynn Menz
N2 - The observations drawn on the patients in the 2 case studies presented indicate that focal cerebral metabolism can be reinstituted by vasopressor-drug therapy in some cases in which arteriography resulted in cerebral complications. Although vasodilators have also been used for similar complications, undramatic results might suggest that these drugs are not indicated in such cases. Increasing total cerebral blood flow in itself does not affect therapy. There must be an increase in blood flow and restoration of metabolism to the ischemic area to assure effective therapy.
KW - Vasoconstricting agents--therapy--for complications of cerebral arteriography;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Francis, T. C.
AU - Oppenheim, J. J.
T1 - IMPAIRED LYMPHOCYTE STIMULATION BY SOME STREPTOCOCCAL ANTIGENS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS AND RHEUMATIC HEART DISEASE.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1970/04//
VL - 6
IS - 4
M3 - Article
SP - 573
EP - 586
SN - 00099104
AB - The effects of pathogenic and non-pathogenic streptococci, streptococcal cell wall products, and phytohaemagglutinin on human peripheral leucocyte cultures from four groups were studied. These groups were; (1) normals, (2) patients with aphthous stomatitis, (3) patients with Behçet's disease, and (4) patients with rheumatic heart disease. The degree of lymphocyte stimulation by these materials was measured by uptake of [3H]thymidine into DNA in vitro. In normals, patients with aphthous stomatitis, and Behçet's disease, the human pathogenic group A streptococci produced significantly greater stimulation of DNA synthesis than did the less pathogenic non-haemolytic streptococci. Lymphocytes from patients with aphthous stomatitis showed significantly less stimulation of DNA synthesis than comparable normal controls when exposed to heat-killed Streptococcal 2A, organisms which have been implicated in the disease. Human pathogenic strains of group A streptococci which have been implicated in rheumatic heart disease stimulated. significantly less in vitro proliferation of lymphocytes froth patients with rheumatic heart disease than of those from a comparable group of normal controls. This hypo-responsiveness persisted when the patients' lymphocytes were cultured in normal human serum. The chronically ill Behçet's patients' lymphocytes did not differ significantly from normal. These observations indicate a deficiency of the cellular response of certain patients to antigens from organisms thought to be aetiologically related to their disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - STREPTOCOCCUS
KW - STOMATITIS
KW - ORAL diseases
KW - CARDIOLOGY
KW - BLOOD plasma
KW - LEUCOCYTES
N1 - Accession Number: 14587216; Francis, T. C. 1; Oppenheim, J. J. 1; Source Information: Apr70, Vol. 6 Issue 4, p573; Subject: LYMPHOCYTES; Subject: STREPTOCOCCUS; Subject: STOMATITIS; Subject: ORAL diseases; Subject: CARDIOLOGY; Subject: BLOOD plasma; Subject: LEUCOCYTES; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY -
AU - Damm, Vernon J.1
T1 - Creativity and Intelligence: Research Implications for Equal Emphasis in High School.
JO - Exceptional Children
JF - Exceptional Children
J1 - Exceptional Children
PY - 1970/04//
Y1 - 1970/04//
VL - 36
IS - 8
CP - 8
M3 - Article
SP - 565
EP - 569
SN - 00144029
AB - The possible relationships among creativity, intelligence, and self actualization were examined in 208 high school students to determine whether or not consistent self actualization scores existed for subjects high in the first two variables. Students high in both creativity and intelligence had significantly higher scores in self actualization than those obtained by students high in either creativity or intelligence. No significant difference in self actualization was found between students high in creativity only and those high in intelligence only. The results were interpreted as indicating that educational systems should stress both intellectual and creative abilities to achieve the highest level of psychological well being in students. [ABSTRACT FROM AUTHOR]
KW - Education
KW - Creative ability
KW - Intellect
KW - Self-actualization (Psychology)
KW - High school students -- Attitudes
KW - High school students
KW - High schools
KW - Education -- Research
KW - Educational surveys
N1 - Accession Number: 19708404; Authors: Damm, Vernon J. 1; Affiliations: 1: Project Director, US Public Health Service Grant for Curriculum Development, School of Nursing, University of Portland, Oregon; Subject: Creative ability; Subject: Intellect; Subject: Self-actualization (Psychology); Subject: High school students -- Attitudes; Subject: High school students; Subject: High schools; Subject: Education; Subject: Education -- Research; Subject: Educational surveys; Number of Pages: 5p; Illustrations: 3 Charts; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
T1 - Spectral studies of trimethylsilyl ether of chloramphenicol
CT - Spectral studies of trimethylsilyl ether of chloramphenicol
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/04/01/
VL - 59
IS - Apr
SP - 501
EP - 510
SN - 00223549
AD - National Center for Antibiotics and Insulin Analysis, Division of Pharmaceutical Sciences, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 7-3467; Language: English; Chemical Name: Chloramphenicol--56-75-7; References: 24; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
N2 - The trimethylsilyl ether of chloramphenicol used in GLC analysis has been characterized by UV, near IR, IR, NMR, and mass spectroscopy, confirming the structure of the O,O-ditrimethyl siloxy derivative. Pyridine and acetonitrile, used as solvents in the silylation reaction, promote formation of diastereomers. Addition of hydroxylic solvents promotes the inversion of configuration and causes partial solvolysis. To verify this, 2 fractions were collected from a GLC column and analyzed by IR and mass spectroscopy. The experimental evidence presented establishes the 2 fractions as diastereomers. IR, NMR, and mass spectrum are illustrated and chromatographs included.
KW - Chloramphenicol--trimethylsilyl ether-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lowenbraun, Stanley
AU - Ramsey, Harold
AU - Sutherland, John
AU - Serpick, Arthur A.
T1 - Diagnostic Laparotomy and Splenectomy for Staging Hodgkin's Disease.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1970/05//
VL - 72
IS - 5
M3 - Article
SP - 655
EP - 663
SN - 00034819
AB - Diagnostic laparotomies and splenectomies were performed on 12 patients to determine more accurately the extent of Hodgkin's disease in the abdomen. Preoperatively, the patients were carefully staged as recommended by the Rye Conference in 1966. At laparotomy four out of nine positive lymphograms were uncorroborated by surgical findings and biopsies, as was one positive inferior vena cavogram. Splenic disease was found in four out of six patients whose preoperative evaluations were negative in this regard. Hodgkin's infiltration of porta hepatic, splenic hilar, and mesenteric lymph nodes was found in three, two, and one patient, respectively. In one patient a retroperitoneal mass was discovered that extended 4 cm laterally to nodes visualized by lymphography and outside usual fields for radiotherapy. None of the hepatic wedge biopsies were positive. Three patients had their stages changed on the basis of laparotomy findings, and an additional seven patients had changes in their known extent of lymphomatous involvement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ABDOMINAL surgery
KW - SPLENECTOMY
KW - HODGKIN'S disease
KW - EXCISION (Surgery)
KW - SPLEEN -- Surgery
KW - LYMPHOMAS
N1 - Accession Number: 12556452; Lowenbraun, Stanley 1; Ramsey, Harold 1; Sutherland, John 1; Serpick, Arthur A. 1; Source Information: May70, Vol. 72 Issue 5, p655; Subject: ABDOMINAL surgery; Subject: SPLENECTOMY; Subject: HODGKIN'S disease; Subject: EXCISION (Surgery); Subject: SPLEEN -- Surgery; Subject: LYMPHOMAS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Martin, W. R.;
AU - Hoeldtke, R. D.;
T1 - Effects of short and long-term administration of pentazocine in man
CT - Effects of short and long-term administration of pentazocine in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/05/01/
VL - 11
IS - May-Jun
SP - 385
EP - 403
SN - 00099236
AD - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 7-3219; Language: English; Chemical Name: Pentazocine--359-83-1; References: 31; Journal Coden: CLPTAT; Section Heading: Pharmacology
N2 - Pentazocine produces morphine-like subjective effects. A dose of 60 mg. per 70 kg. produces subjective effects which more closely resemble those of nalorphine than those of morphine. Pentazocine will not suppress abstinence symptoms in subjects dependent on either 60 or 240 mg. per day of morphine. Pentazocine is 1/50 as potent as nalorphine in precipitating abstinence symptoms in subjects dependent on 240 mg. of morphine per day. Long-term administration of pentazocine produces dependence which has elements of both morphine and nalorphine dependence. It is concluded that pentazocine has an abuse potential which is less than that with morphine but greater than that with nalorphine.
KW - Pentazocine--effects-;
KW - Dependence--pentazocine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Banhalmi, Z.;
AU - Benko, G.;
AU - Kenez, E.;
T1 - Application of synthetic plastics in pharmaceutical packaging
CT - Application of synthetic plastics in pharmaceutical packaging
JO - Gyogyszereszet (Hungary)
JF - Gyogyszereszet (Hungary)
Y1 - 1970/05/01/
VL - 5
IS - May
SP - 173
EP - 180
SN - 00176036
AD - Public Health Service of the Peoples Army, Budapest, Hungary
N1 - Accession Number: 7-2889; Language: Hungarian; Language of Summary: eng; ger; rus; References: 23; Journal Coden: GYOGAI; Section Heading: Pharmaceutical Technology; Abstract Author: Theresa F. Lantos
N2 - The authors discuss the application of synthetic plastics, when used for packaging pharmaceuticals. The first part of this discussion deals with the interaction of these plastics with the drugs with which they are packaged and also with their toxicity. The plastic containers used for packaging infusions and also the method of their sterilization are discussed at length. The storage of blood preparations and the results of transfusions performed with blood stored in plastic vessels are also discussed.
KW - Plastics--application in pharmaceutical packaging;
KW - Packaging--pharmaceuticals--application of synthetic plastics;
KW - Drug interactions--with plastics;
KW - Containers--plastics--application in pharmaceutical packaging;
KW - Toxicity--plastics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stein, C.;
T1 - TLC separation and spectrophotometric determination of 1-(2-hydroxy-1-naphthylazo)-2-naphthalene sulfonic acid in D&C Red No. 12
CT - TLC separation and spectrophotometric determination of 1-(2-hydroxy-1-naphthylazo)-2-naphthalene sulfonic acid in D&C Red No. 12
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 534
EP - 535
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2814; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - D&C Red No. 12--analysis-;
KW - Sulfonic acids--1-(2-hydroxy-1-naphthylazo)-2-naphthalene--analysis, in D&C Red No. 12;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wells, C. E.;
AU - Miller, H. M.;
AU - Pfabe, Y. H.;
T1 - Rapid colorimetric assay for nitroglycerin, suitable for content uniformity testing
CT - Rapid colorimetric assay for nitroglycerin, suitable for content uniformity testing
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 579
EP - 581
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 7-2607; Language: English; Chemical Name: Nitroglycerin--55-63-0; References: 7; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A precise and rapid colorimetric method is described which is based on the hydrolysis of nitroglycerin with tetramethylammonium hydroxide in nonaqueous systems yielding 2 moles of nitrite ion for each mole of nitroglycerin. The nitrite ion formed is used to diazotize p-chloroaniline which is then reacted with N-1-naphthyl-ethylenediamine. Interferences are removed by a column chromatographic procedure. These experiments show that the colorimetric and AOAC (Association of Official Analytical Chemists) methods give results which agree within 1% on the average and that the colorimetric method is more precise. The colorimetric method is also sensitive enough to be used for individual tablet analysis and the color development may be automated. The results on commercial samples show that the colorimetric method is applicable to a wide range of samples. No interferences with the method were found in any of these samples. The method agrees closely with the AOAC infrared method and is sensitive enough for analysis of individual tablets (0.15 mg. nitroglycerin). The standard deviation is 0.91% at the 1.2 mg. level.
KW - Nitroglycerin--analysis-;
KW - Tablets--nitroglycerin--analysis, colorimetric;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazzari, F. R.;
T1 - Extraction and spectrophotometric determination of benzthiazide, hydrochlorothiazide, and hydroflumethiazide in pharmaceuticals
CT - Extraction and spectrophotometric determination of benzthiazide, hydrochlorothiazide, and hydroflumethiazide in pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 582
EP - 584
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-3038; Language: English; Chemical Name: Benzthiazide--91-33-8 Hydrochlorothiazide--58-93-5 Hydroflumethiazide--135-09-1; References: 8; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The described procedure involves the use of both column partition chromatography and liquid-liquid extraction. The procedure is rapid and specific and employs established separation techniques. The active ingredient is eluted from a basic Celite column with an acetic acid-ether solvent and extracted from the organic phase into sodium hydroxide for the spectrophotometric determination. The method will not distinguish between active ingredient and the 4-amino-6-chloro-m-benzenedisulfonamide decomposition product which may be present with hydrochlorothiazide and hydroflumethiazide.
KW - Benzthiazide--analysis-;
KW - Hydrochlorothiazide--analysis-;
KW - Hydroflumethiazide--analysis-;
KW - Thiazides--analysis--spectrophotometric, following extraction from dosage forms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - More, C. A.;
AU - Kenner, C. T.;
T1 - Cautionary note concerning color stability in reineckate salt analyses
CT - Cautionary note concerning color stability in reineckate salt analyses
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 588
EP - 591
AD - Food and Drug Administration, 3032 Bryan Street, Dallas, Texas 75204
N1 - Accession Number: 7-2804; Language: English; Chemical Name: Betaine--107-43-7 Choline--62-49-7 Homatropine--87-00-3; References: 6; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - This paper reports the variation of absorbance with time in acetone and aqueous acetone for the reinecke salts of betaine, choline chloride, and homatropine methylbromide and points out the necessity of close control of the time lapse between solution of the precipitated salt and photometric measurement in reinecke salt procedures. Procedures should be modified so that absorbance measurements are made as soon as possible after dissolving the salt and so that the time lapse between solution and measurement is uniform for all samples and standards. The effect of time and temperature of precipitation on the absorbance of the reinecke salts of betaine, choline chloride, and homatropine methylbromide is shown.
KW - Betaine--analysis-;
KW - Choline--chloride-;
KW - Homatropine--methylbromide-;
KW - Salts--reinecke--stability, in betaine, choline chloride, and homatropine methylbromide analysis;
KW - Stability--reinecke salts--precautions, in analysis of betaine, choline chloride, and homatropine methylbromide;
KW - Analysis--quaternary ammonium compounds--precautions regarding reinecke salt stability;
KW - Reinecke salts--stability--precautions, in analysis of quaternary ammonium compounds;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hohmann, J. R.;
T1 - Collaborative study of the analysis of acetaminophen in a syrup and in combination with other drugs in a tablet
CT - Collaborative study of the analysis of acetaminophen in a syrup and in combination with other drugs in a tablet
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 591
EP - 594
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2608; Language: English; Chemical Name: Acetaminophen--103-90-2; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The slightly modified procedure of Levine and Hohmann, which separated acetaminophen from acidic, basic, and neutral substances by a buffered partition chromatographic systems was used to determine acetaminophen in a syrup, elixir, tablet, and solution. The same basic column and solvent system was satisfactory for determination of acetaminophen in a tablet containing amphetamine, butabarbital, aspirin, and salicylamide. The precision of the analyses of all samples and the accuracy for 2 syrups and a tablet mixture were satisfactory. Since there is no official method for the determination of acetaminophen alone in liquids, nor in combinations in either the liquid or solid dosage forms, it is recommended that this method be adopted.
KW - Acetaminophen--analysis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hamilton, J. L., Jr.;
T1 - Collaborative study of the analysis of pentaerythritol tetranitrate and meprobamate in tablets
CT - Collaborative study of the analysis of pentaerythritol tetranitrate and meprobamate in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 594
EP - 598
AD - Food and Drug Administration, 900 Madison Avenue, Baltimore, Maryland 21201
N1 - Accession Number: 7-3040; Language: English; Chemical Name: Meprobamate--57-53-4; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Meprobamate and pentaerythritol tetranitrate (PETN) are separated by selective elution from a mixed Celite-sodium hydroxide-phosphoric acid column, using chloroform and benzene, respectively, as eluting solvents. PETN and meprobamate are detected and quantitatively measured by IR spectrophotometry. A collaborative study gave an average recovery of 99.3% for PETN and 99.95% for meprobamate. A precautionary note regarding the fact that PETN may explode when heated strongly, even when dissolved, is given.
KW - Pentaerythritol--tetranitrate, combination, meprobamate-;
KW - Meprobamate--combination, pentaerythritol tetranitrate-;
KW - Analysis--meprobamate, combination, pentaerythritol tetranitrate--column chromatography and spectrophotometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brannon, W. L.;
T1 - Comparative study of micro infrared techniques
CT - Comparative study of micro infrared techniques
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 599
EP - 603
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2592; Language: English; References: 7; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - The purpose of this investigation was to obtain meaningful spectra with the least amount of sample and using the simplest equipment and technique possible. A comparative study was made of 10 techniques used in the isolation and identification of microgram quantities (0.5-15 mcg.) of drugs by IR spectroscopy. The isolation techniques include preparative GLC and TLC. In the case of TLC, silica gel interference was nearly eliminated by using a sintered glass filter and vacuum. The identifications were enhanced by concentrating the sample in the IR beam center. The sample was centered either with the aid of a cardboard silhouette or punched out or drilled indentations in the KBr disk.
KW - Spectrometry--infrared--micro, comparative study of 10 techniques;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, E.;
T1 - Collaborative study of the determination of morphine in opium
CT - Collaborative study of the determination of morphine in opium
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 603
EP - 608
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2609; Language: English; Chemical Name: Morphine--57-27-2 Dimethyl sulfoxide--67-68-5 Opium--8008-60-4; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A partition chromatographic procedure which was successfully used in the determination of morphine in paregoric was applied to the determination of morphine in opium. Two methods of preparation of the opium solution before partition were studied: homogenization in a high speed blender and use of DMSO (dimethyl sulfoxide) as a solvent. Reproducible results were obtained with the use of DMSO solutions. The standard deviations obtained for samples containing 7.82, 13.88, 12.45, 14.87, and 15.74% anhydrous morphine were 0.171, 0.184, 0.207, 0.220, and 0.307, respectively. From the results obtained, the method using DMSO in the preparation of the sample solution, together with the partition chromatographic method is recommended for adoption.
KW - Morphine--analysis-;
KW - Dimethyl sulfoxide--solvent-;
KW - Opium--analysis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Reiss, T. J.;
T1 - Note on gas chromatographic determination of antihistamines employing a dual column direct injection system
CT - Note on gas chromatographic determination of antihistamines employing a dual column direct injection system
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/05/01/
VL - 53
IS - May
SP - 609
EP - 611
AD - Food and Drug Administration, 850 Third Avenue, Brooklyn, New York 11232
N1 - Accession Number: 7-3041; Language: English; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A GLC method is presented for the rapid direct analysis of antihistamines in pharmaceuticals in which the common interfering components are separated by gas chromatography. A dual column system makes it possible to separate each of the antihistamine peaks from each of the 7 most common accompanying component peaks. A simple one-step extraction procedure is given for the separation of flavoring materials in syrups. Since only 1 or 2 antihistamines are present in any given sample, peak overlapping does not usually present a problem. Deviations from linearity on each column tested were minimal.
KW - Antihistamines--analysis--chromatography, gas;
KW - Chromatography, gas--antihistamines--in pharmaceuticals, using dual column direct injection system;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hall, R.;
T1 - Tricyclic antidepressant tranquilizers (dibenzazepine compounds)
CT - Tricyclic antidepressant tranquilizers (dibenzazepine compounds)
JO - Natl. Clearinghouse Poison Contr. Cent. Bull.
JF - Natl. Clearinghouse Poison Contr. Cent. Bull.
Y1 - 1970/05/01/
VL - Pages
IS - May-Jun
SP - 1
EP - 2
AD - National Clearinghouse for Poison Control Centers, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-2676; Language: English; References: 12; Journal Coden: NCPBBY; Section Heading: Toxicity; Abstract Author: A. Leon Moore
N2 - The author reviews intoxication from the tricyclic antidepressant tranquilizers. Compounds covered include imipramine, desipramine, amitriptyline, nortriptyline, protriptyline, trimipramine and opipramol. The recently introduced doxepin hydrochloride is also included in the review. The author presents 5 case histories and a tabular survey of 97 cases of intoxications in children and adults where known amounts of the drugs were ingested. Treatment of tricyclic antidepressant intoxication requires support of the cardiovascular and respiratory systems, and the use of anticonvulsant drugs when indicated. The author reviews the value of anti-arrhythmics, vasopressors, diuretics and intravenous fluids.
KW - Toxicity--antidepressants--tricyclic, intoxication, and therapy;
KW - Poisoning--antidepressants--tricyclic, intoxication, and therapy;
KW - Antidepressants--tricyclic--intoxication, therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Suggs, J. E.;
AU - Hawk, R. E.;
AU - Curley, A.;
AU - Boozer, E. L.;
AU - McKinney, J. D.;
T1 - DDT metabolism: oxidation of the metabolite 2,2-bis(\LC/p\UC/-chlorophenyl)ethanol by alcohol dehydrogenase
CT - DDT metabolism: oxidation of the metabolite 2,2-bis(\LC/p\UC/-chlorophenyl)ethanol by alcohol dehydrogenase
JO - Science
JF - Science
Y1 - 1970/05/01/
VL - 168
IS - May 1
SP - 582
AD - Atlanta Toxicology Branch, Division of Pesticides, Bureau of Science, Food and Drug Administration, Atlanta, Georgia 30333
N1 - Accession Number: 8-0266; Language: English; Trade Name: DDT; Generic Name: Chlorophenothane; Chemical Name: Chlorophenothane--50-29-3; References: 3; Journal Coden: SCIEAS; Section Heading: Drug Metabolism and Body Distribution
N2 - A metabolite of DDT (chlorophenothane), 2,2-bis(p-chlorophenyl)ethanol, is a substrate of crystalline liver alcohol dehydrogenase. The oxidation of the substrate was detected spectrophotometrically. The p-nitrophenylhydrazone derivative of the product, 2,2-bis(p-chlorophenyl)acetaldehyde, was identified by comparing its mass spectrum and thin layer chromatographic behavior with that of an authentic sample.
KW - Chlorophenothane--metabolites-;
KW - 2,2-Bis(p-chlorophenyl)ethanol--oxidation-;
KW - Oxidation--chlorophenothane--metabolites, 2,2-bis(p-chlorophenyl)ethanol oxidized by alcohol dehydrogenase;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1990-55889-001
AN - 1990-55889-001
AU - Weisenberg, Matisyohu
T1 - Role of psychology in the delivery of health services.
T3 - The Place of Psychology in the Universe
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1970/05//
VL - 25
IS - 5
SP - 472
EP - 472
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1990-55889-001. Partial author list: First Author & Affiliation: Weisenberg, Matisyohu; US Public Health Service, National Ctr for Health Services Research & Development, Arlington, VA, US. Release Date: 19900101. Correction Date: 20100308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Health Care Delivery; Psychologists. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 1. Issue Publication Date: May, 1970. Copyright Statement: American Psychological Association. 1970.
AB - Comments on W. Schofield's (1969) statement that there are areas in health care delivery that have been untapped by psychologists. The National Center for Health Services Research and Development provides support in these areas of research. However, psychologists have failed to take advantage of these opportunities. (0 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - delivery of health care services
KW - psychologists
KW - commentary
KW - 1970
KW - Health Care Delivery
KW - Psychologists
KW - 1970
DO - 10.1037/h0037748
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Larry, D.;
AU - Fuller, M. J.;
AU - Harrill, P. G.;
T1 - Quantitation of ammonium glycyrrhizinate by gas-liquid chromatography of the silyl ether ester derivative of the aglycone
CT - Quantitation of ammonium glycyrrhizinate by gas-liquid chromatography of the silyl ether ester derivative of the aglycone
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 698
EP - 700
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-3730; Language: English; References: 12; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A gas chromatographic method for quantitative determination of the flavoring agent, ammonium glycyrrhizinate, is described. The aglycone obtained in a chloroform extract after acid hydrolysis in a dioxane-water mixture is silylated forming an ether ester derivative suitable for gas chromatographic analysis.
KW - Ammonium glycyrrhizinate--analysis-;
KW - Flavors--ammonium glycyrrhizinate--analysis, GLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazio, T.;
AU - Howard, J. W.;
T1 - Collaborative study of a method for cyclohexylamine in cyclamates and artificially sweetened beverages
CT - Collaborative study of a method for cyclohexylamine in cyclamates and artificially sweetened beverages
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 701
EP - 704
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4187; Language: English; Chemical Name: Cyclohexylamine--108-91-8; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The results of a collaborative study indicate that cyclohexylamine can be determined reliably in cyclamates and beverages by the method presented. The amine is isolated by an extraction and/or distillation technique, determined by gas chromatography, and confirmed by IR spectroscopy. The purity of the methylene chloride used in the extraction procedure should be confirmed since some lots of solvent contained a contaminant which reacted with the amine to form cyclohexylamine hydrochloride. An alkaline wash of the methylene chloride corrected this problem.
KW - Cyclohexylamine--analysis-;
KW - Cyclamates--analysis--for cyclohexylamine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pla, G. W.;
AU - Fritz, J. C.;
T1 - Availability of iron
CT - Availability of iron
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 791
EP - 800
AD - Division of Nutrition, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-0057; Language: English; Chemical Name: Iron--7439-89-6; References: 203; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The object of this study was to establish a criterion for measuring availability of supplemental iron sources. Chicks and rats were used as test animals for comparing the utilization of iron from different compounds and food sources. A list of iron sources is presented which categorizes the source as good, mediocre or poor. The preliminary data in the study indicated that the in vitro solubility tests are not satisfactory in evaluating the availability of iron in iron supplements. It was recommended that the study be continued, with the objective of developing a satisfactory method for measuring availability of iron sources used in food fortification.
KW - Iron--availability-;
KW - Absorption--iron--availability, measured in animal studies;
KW - Drugs--availability--iron, sources, measurement, animal studies;
KW - Tests--availability--iron, in vitro solubility, inadequate;
KW - Nutrition--iron--measurement of availability in supplements, animal studies;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Page, D. P.;
T1 - Semiautomated method for the determination of reserpine in tablets
CT - Semiautomated method for the determination of reserpine in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 815
EP - 818
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 7-3731; Language: English; Chemical Name: Reserpine--50-55-5; References: 12; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The described method was used at the National Center for Drug Analysis as a screening procedure for approximately 1000 samples representing 108 different reserpine formulations from 60 manufacturers. In this method a chloroform solution of reserpine tablets is automatically sampled, washed successively with aqueous solutions of citric acid and sodium bicarbonate, and diluted with methanol. The chloroform-methanol solution is split into 3 streams: one flows sequentially through 2 UV spectrophotometers, recording the absorbances at 268 and 295 mm.; the other 2 streams are used for the colorimetric assay (addition of hydrochloric acid and sodium nitrite) and blank (HCl only). Day-to-day relative standard deviations were 0.40-0.95%. The method has been compared with Barkan's chromatographic procedure and the U.S.P. XVII method.
KW - Reserpine--analysis-;
KW - Automation--analysis--reserpine tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Woodson, A. L.;
T1 - Chromatographic separation and spectrophotometric analysis of a multicomponent drug formulation containing methylene blue
CT - Chromatographic separation and spectrophotometric analysis of a multicomponent drug formulation containing methylene blue
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 819
EP - 823
AD - Food and Drug Administration, 433 W. Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 7-3732; Language: English; Chemical Name: Methylene blue--7220-79-3 Benzoic acid--65-85-0 Methenamine--100-97-0 Phenyl salicylate--118-55-8 Atropine--51-55-8 Hyoscyamine--101-31-5; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The analytical procedure for individual components of a tablet containing atropine sulfate 0.03 mg., hyoscyamine 0.03 mg., phenyl salicylate 18.1 mg., benzoic acid 4.5 mg., methenamine 40.8 mg., and methylene blue 5.4 mg., is described. The first 4 components are isolated by partition chromatography on acid and base Celite columns, then quantitated by spectrophotometric methods. Methenamine is separated and quantitated by GLC, while methylene blue is quantitated by visible spectrophotometry without prior separation. The assay procedures were applied to the nonalkaloidal components of 3 commercial samples and a synthetic mixture of the nonalkaloidal components. The assay of the alkaloids was not performed since it has already been shown that this formulation might be successfully assayed.
KW - Methylene blue--analysis-;
KW - Benzoic acid--analysis-;
KW - Methenamine--analysis-;
KW - Phenyl salicylate--analysis-;
KW - Atropine--sulfate-;
KW - Hyoscyamine--separation-;
KW - Analysis--mixtures--multicomponent tablets, containing methylene blue;
KW - Tablets--multicomponent--containing methylene blue, analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Andres, C. N.;
T1 - Microcrystalline identification of phenothiazine type tranquilizers. II. Collaborative study
CT - Microcrystalline identification of phenothiazine type tranquilizers. II. Collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 824
EP - 827
AD - Food and Drug Administration, 20th and California Streets, Denver, Colorado 80202
N1 - Accession Number: 7-4188; Language: English; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers phenothiazines; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The collaborative results for the identification of phenothiazine tranquilizers using characteristic crystal tests are presented. It was recommended that the following crystal systems be adopted as identification tests: acetophenazine-picric acid, chlorprothixene-ammonium reineckate, fluphenazine-picric acid, mepazine-ammonium thiocyanate, mepazine-gold chloride, promazine-gold chloride, promethazine-ammonium reineckate, promethazine-platinum bromide, propiomazine-ammonium reineckate, and trifluoperazine-stannous chloride. Some difficulties were encountered in distinguishing between phenothiazine-ammonium reineckate crystals.
KW - Analysis--phenothiazines--microcrystalline identification;
KW - Phenothiazines--analysis--microcrystalline identification;
KW - Tranquilizers--phenothiazines--analysis, microcrystalline identification;
KW - Crystallography--phenothiazines--identification tests;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cunningham, C. G.;
T1 - Evaluation of methods to establish the natural origin of adrenal cortex injections
CT - Evaluation of methods to establish the natural origin of adrenal cortex injections
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 828
EP - 830
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-3733; Language: English; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A 2-dimensional thin layer chromatographic method was successfully used to analyze adrenal cortex injections adulterated with synthetic steroids. The presence or absence of nonsteroidal substances naturally present in animal glands is also demonstrable in the chromatograms. It was concluded that there is a need for an international standard of identity of adrenal cortex extract to determine the purity and potency of the injection.
KW - Adrenal cortex--injections-;
KW - Standards--adrenal cortex--injections, international, need;
KW - Adulteration--adrenal cortex--injections, detection, using 2-dimensional TLC;
KW - Chromatography, thin layer--2-dimensional--detection of adulterants in adrenal cortex injections;
KW - Steroids, cortico---synthetic--adulterants, in adrenal cortex injections, identification using 2-dimensional TLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wu, J. Y. P.;
T1 - Colorimetric determination of the progestational steroids in contraceptive tablets
CT - Colorimetric determination of the progestational steroids in contraceptive tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 831
EP - 833
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-3734; Language: English; Chemical Name: Norethindrone--68-22-4 Dimethisterone--41354-30-7 Medroxyprogesterone--520-85-4 Norethynodrel--68-23-5; References: 9; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Norethindrone, norethindrone acetate, dimethisterone, medroxyprogesterone acetate, and norethynodrel are determined in oral contraceptive tablets. For the first 4 compounds, a chloroform extract of the tablets is treated directly with isonicotinyl hydrazide reagent to produce a stable color which is measured at 380 nm. The chloroform extract of norethynodrel tablets is isomerized before the reagent is added. An intralaboratory study gave good results, with standard deviations of 0.74 to 1.21%.
KW - Norethindrone--analysis-;
KW - Norethindrone--acetate-;
KW - Dimethisterone--analysis-;
KW - Medroxyprogesterone--acetate-;
KW - Norethynodrel--analysis-;
KW - Tablets--contraceptives, oral--constituents, progestogens, analysis;
KW - Contraceptives, oral--tablets--analysis, of progestogen constituents;
KW - Analysis--contraceptives, oral--tablets, progestogen constituents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Davidson, A. W.;
T1 - Collaborative study of a gas chromatographic determination of ethchlorvynol in drugs
CT - Collaborative study of a gas chromatographic determination of ethchlorvynol in drugs
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 834
EP - 839
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 7-3735; Language: English; Trade Name: Placidyl; Generic Name: Ethchlorvynol; Chemical Name: Ethchlorvynol--113-18-8; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A collaborative study of a gas chromatographic method using 1,3-dichloro-2-propanol as the internal standard and Carbowax 20M as the liquid phase is described. All collaborators obtained good recoveries on known (500 mg. Placidyl capsules) and unknown samples.
KW - Ethchlorvynol--analysis-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, D. J.;
T1 - Methods for some alkaloids, barbiturates, and combinations. I. Review of selected methods and development of an ion exchange method for ephedrine sulfate or amphetamine sulfate alone or combined with barbiturates and antihistamines
CT - Methods for some alkaloids, barbiturates, and combinations. I. Review of selected methods and development of an ion exchange method for ephedrine sulfate or amphetamine sulfate alone or combined with barbiturates and antihistamines
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 840
EP - 855
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 7-3736; Language: English; Chemical Name: Amphetamine--300-62-9 Ephedrine--299-42-3; References: 64; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A variety of methods, excluding gas chromatography, for the isolation and determination of the title compounds are reviewed. An ion exchange method for the analysis of amphetamine sulfate or ephedrine sulfate alone or combined with barbital sodium or phenobarbital and pyrilamine maleate, methapyrilene hydrochloride, or tripelennamine citrate is described.
KW - Amphetamine--sulfate-;
KW - Ephedrine--sulfate-;
KW - Analysis--alkaloids, barbiturates and combinations--selected methods, review;
KW - Barbiturates--alone and in combinations--analysis, selected methods, review;
KW - Alkaloids--alone and in combinations--analysis, selected methods, review;
KW - Antihistamines--analysis--combinations, selected methods;
KW - Chromatography--ion exchange--selected methods for alkaloids, barbiturates and combinations, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, D. J.;
T1 - Methods for some alkaloids, barbiturates, and combinations. II. Collaborative study of an ion exchange method for ephedrine sulfate or amphetamine sulfate alone or combined with barbiturates and antihistamines
CT - Methods for some alkaloids, barbiturates, and combinations. II. Collaborative study of an ion exchange method for ephedrine sulfate or amphetamine sulfate alone or combined with barbiturates and antihistamines
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/07/01/
VL - 53
IS - Jul
SP - 847
EP - 855
AD - Food and Drug Administration, 50 Fulton St., San Francisco, California 94102
N1 - Accession Number: 7-3947; Language: English; Chemical Name: Ephedrine--299-42-3 Amphetamine--300-62-9; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The use of polystyrenesulfonate cation and quaternary ammonium anion exchange resin columns for the separation and determination of the title compounds is described. The amines are retained on a cation column as substituted amine salts and are eluted in order of their increasing basicities with appropriate concentrations of HCl. The barbiturates pass through a cation exchange column and are weak enough acids so that they pass through the chloride form of an anion exchange column. A UV determinative step measures the absorbance of the phenyl moiety. The anion exchange column in the chloride form retains most of the coloring found in tablets and syrups. It was recommended that the method be adopted as offic ial.
KW - Ephedrine--sulfate-;
KW - Amphetamine--sulfate-;
KW - Analysis--alkaloids, barbiturates and combinations--chromatography, ion exchange;
KW - Chromatography--ion exchange--alkaloids, barbiturates and combinations;
KW - Alkaloids--alone and in combinations--chromatography, ion exchange;
KW - Barbiturates--alone and in combinations--chromatography, ion exchange;
KW - Antihistamines--chromatography--ion exchange, combined with alkaloids or barbiturates;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lambert, J. P. F.;
AU - Margosis, M.;
T1 - Rapid determination of aluminum in pharmaceutical dosage forms by neutron activation
CT - Rapid determination of aluminum in pharmaceutical dosage forms by neutron activation
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/07/01/
VL - 59
IS - Jul
SP - 1005
EP - 1007
SN - 00223549
AD - Division of Food Chemistry and Technology and Division of Pharmaceutical Sciences, National Center for Antibiotics and Insulin Analysis, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 8-0482; Language: English; Chemical Name: Aluminum--7429-90-5; References: 4; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - The relatively short half-life of \SU/28\BS/Al allows rapid analysis, and the technique favors the detection of aluminum over possible interferences by longer lived radionuclides. Tables are included and x-ray spectra illustrated.
KW - Aluminum--analysis-;
KW - Analysis--aluminum--rapid determination in pharmaceutical dosage forms by neutron activation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Calhoun, M. P.;
AU - White, M.;
AU - Bowman, F. W.;
T1 - Sterility testing of insulin by membrane filtration: a collaborative study
CT - Sterility testing of insulin by membrane filtration: a collaborative study
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/07/01/
VL - 59
IS - Jul
SP - 1022
EP - 1024
SN - 00223549
AD - Division of Pharmaceutical Sciences, National Center for Antibiotics and Insulin Analysis, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 8-0714; Language: English; Chemical Name: Insulin--9004-10-8; References: 11; Journal Coden: JPMSAE; Section Heading: Microbiology; Pharmaceutical Technology; Abstract Author: D. R. Tousignaut
N2 - A collaborative study showed that the filtration procedure afforded significant improvements over the direct method of sterility testing. In each individual test by membrane filtration the microorganisms grew in one of the 2 media within 7 days. However, the U.S.P./N.F. direct method required 10 days of incubation for visual detection. Several advantages accrue from the use of the filtration test. The incubation time is shortened from 14 to 7 days, the necessity for subculturing turbid broth tubes to determine the presence or absence of microbial growth is eliminated, and the volume of medium required for testing is drastically reduced.
KW - Insulin--sterility-;
KW - Sterility--tests--insulin, advantages of membrane filtration procedure;
KW - Tests--sterility--insulin, advantages of membrane filtration procedure;
KW - Filtration--membrane--sterility testing of insulin, advantages;
KW - Filters--membrane--sterility testing of insulin, advantages;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Olson, J. C.;
T1 - Some considerations relative to microbial contamination of cosmetics
CT - Some considerations relative to microbial contamination of cosmetics
JO - Am. Perfum. Cosmet.
JF - Am. Perfum. Cosmet.
Y1 - 1970/08/01/
VL - 85
IS - Aug
SP - 43
EP - 46
AD - Division of Microbiology, Food and Drug Administration, Department of Health, Education and Welfare, Washington, D. C.
N1 - Accession Number: 8-0283; Language: English; Language of Summary: fr; ger; sp; References: 9; Journal Coden: APRCAS; Section Heading: Legislation, Laws and Regulations; Pharmaceutical Technology; Abstract Author: James E. Karlstrand
N2 - Presented is a review of the FDA regulations with regard to product sterility in the cosmetic field, along with a discussion of enforcement procedures.
KW - Cosmetics--contamination--microorganisms, considerations;
KW - Contamination--cosmetics--microorganisms, considerations;
KW - Microorganisms--contamination--cosmetics, considerations;
KW - Regulations--Food and Drug Administration (U.S.)--regarding product sterility in cosmetic field;
KW - Food and Drug Administration (U.S.)--regulations--regarding product sterility in cosmetic field;
KW - Sterility--cosmetics--regulations, Food and Drug Administration (U.S.);
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0283&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Williams, P. A.;
AU - Kenner, C. T.;
T1 - Detection of decomposition and analytical interferences in pharmaceutical preparations containing corticosteroids
CT - Detection of decomposition and analytical interferences in pharmaceutical preparations containing corticosteroids
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/08/01/
VL - 59
IS - Aug
SP - 1152
EP - 1156
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 8-0619; Language: English; References: 40; Journal Coden: JPMSAE; Section Heading: Drug Stability; Drug Analysis
N2 - Methods are proposed which allow the detection and determination of both acidic and neutral corticosteroid decomposition products. Since the blue tetrazolium and phenylhydrazine reagents for corticosteroids react with the intact side chain at C\IF/17\BS/, and the isonicotinic acid hydrazide method and UV spectrophotometry depend upon conjugation in ring A at the other end of the molecule, the analytical results by the 4 methods give information concerning decomposition caused by oxidation of the C\IF/17 \BS/side chain and by deconjugation in ring A. Measurement of the variation of absorbance with time can be used to detect unidentified interferences in the blue tetrazolium, phenylhydrazine, and isonicotinic acid procedures. The extent of interference of several substances which interfere in at least one of the color reactions is reported. Several examples of the use of the proposed methods to detect and determine decomposition and/or interference are given. Tables are included.
KW - Steroids, cortico---containing pharmaceutical preparations--detection of decomposition and analytical interferences;
KW - Stability--steroids, cortico---containing pharmaceutical preparations, detection of decomposition and analytical interferences;
KW - Analysis--steroids, cortico---in pharmaceutical preparations, detection of decomposition and interferences;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Walton, V. C.;
AU - Howlett, M. R.;
AU - Selzer, G. B.;
T1 - Anhydrotetracycline and 4-epianhydrotetracycline in market tetracyclines and aged tetracycline products
CT - Anhydrotetracycline and 4-epianhydrotetracycline in market tetracyclines and aged tetracycline products
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/08/01/
VL - 59
IS - Aug
SP - 1160
EP - 1164
SN - 00223549
AD - National Center for Antibiotics and Insulin Analysis, Office of Pharmaceutical Sciences, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 8-0620; Language: English; Chemical Name: Tetracycline--60-54-8 Anhydrotetracycline--1665-56-1 Citric acid--77-92-9 Rolitetracycline--751-97-3; Therapeutic Class: (8:12); AHFS Class: Antibiotics tetracycline; References: 20; Journal Coden: JPMSAE; Section Heading: Drug Stability
N2 - A large number of tetracycline samples were tested for the presence of anhydrotetracycline and 4-epianhydrotetracycline when they were fresh and after being stored under normal and adverse conditions. It was found that: (1) Newly manufactured tetracycline preparations contain only small amounts of anhydrotetracycline and 4-epianhydrotetracycline. (2) Storage under adverse conditions markedly increases the percentage of degradation products, but storage under normal conditions results in only a slow increase in anhydrotetracycline and 4-epianhydrotetracycline. In syrups, this can be correlated with loss in tetracycline potency. (3) Citric acid greatly increases the tendency of tetracycline to degrade. (4) Tetracycline hydrochloride is more stable than tetracycline phosphate. (5) Demethylchlortetracycline is the most stable of the tetracycline derivatives studied. (6) Rolitetracycline is extremely unstable. Numerous tables illustrating the above are included.
KW - Tetracycline--and derivatives-;
KW - Anhydrotetracycline--and 4-epianhydrotetracycline-;
KW - Epianhydrotetracycline--4--;
KW - Citric acid--increases tendency of tetracycline to degrade-;
KW - Tetracycline--hydrochloride-;
KW - Tetracycline--phosphate-;
KW - Demethylchlortetracycline--stability-;
KW - Rolitetracycline--stability-;
KW - Stability--tetracycline--and derivatives, tested for presence of anhydrotetracycline and 4-epianhydrotetracycline, when fresh and after storage;
KW - Storage--effects--on presence of anhydrotetracycline and 4-epianhydrotetracycline in tetracycline preparations;
KW - Antibiotics--tetracycline--and derivatives, tested for anhydrotetracycline and 4-epianhydrotetracycline, when fresh and after storage;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0620&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1971-05425-001
AN - 1971-05425-001
AU - Compton, J. William
T1 - Experimenter bias: Reaction time and types of expectancy information.
JF - Perceptual and Motor Skills
JO - Perceptual and Motor Skills
JA - Percept Mot Skills
Y1 - 1970/08//
VL - 31
IS - 1
SP - 159
EP - 168
CY - US
PB - Perceptual & Motor Skills
SN - 0031-5125
SN - 1558-688X
N1 - Accession Number: 1971-05425-001. Other Journal Title: Perceptual & Motor Skills Research Exchange. Partial author list: First Author & Affiliation: Compton, J. William; National Center for Mental Health Services, Training, & Research, Washington, D.C. Other Publishers: Sage Publications. Release Date: 19710401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Expectations; Experimentation; Experimenter Bias; Reaction Time; Response Bias. Minor Descriptor: Rating. Classification: Human Experimental Psychology (2300). Population: Human (10). Page Count: 10. Issue Publication Date: Aug, 1970.
AB - Each of 9 undergraduate male Es received general (personality and IQ), specific (expected performance), or no information about 136 female undergraduates. All information was fabricated. Ss' RT and photo-ratings were used to assess E-expectancy effects. Contrary to the findings of other investigators, Ss' photo-ratings were not significantly influenced by the specific expectancy of E, but their RTs were. Ss' photo-ratings and RTs were not significantly influenced by Es who received general information about their Ss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - E bias
KW - expectancy information of female Ss' RT & photo ratings
KW - male college students
KW - 1970
KW - Expectations
KW - Experimentation
KW - Experimenter Bias
KW - Reaction Time
KW - Response Bias
KW - Rating
KW - 1970
DO - 10.2466/pms.1970.31.1.159
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1971-05425-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Poland, A.;
AU - Smith, D.;
AU - Kuntzman, R.;
AU - Jacobson, M.;
AU - Conney, A. H.;
T1 - Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects
CT - Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1970/09/01/
VL - 11
IS - Sep-Oct
SP - 724
EP - 732
SN - 00099236
AD - Division of Pesticides, Food and Drug Administration, Atlanta, Georgia
N1 - Accession Number: 8-1732; Language: English; Trade Name: DDT; Generic Name: Chlorophenothane; Chemical Name: Chlorophenothane--50-29-3 Phenylbutazone--50-33-9; References: 37; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - The effect of intensive occupational exposure to DDT on drug and steroid metabolism was studied. The concentration of DDT-related substances in the serum and fat of DDT factory workers was 20 to 30 times that in a control population. The serum half-life of phenylbutazone was 19% lower ( \LT/ 0.01) and the urinary excretion of 6\b/-hydroxycortisol was 57% higher ( \LT/ 0.01) in the DDT factory workers. There were considerable variations in the phenylbutazone half-life in different people, and there were also individual differences in the urinary excretion of 6\b/-hydroxycortisol. The variability in these parameters found in the DDT factory workers or in the control population was, however, not correlated with the concentration of DDT in the serum. Although we do not know whether DDT storage in the general population is sufficient to increase phenylbutazone metabolism or the urinary excretion of 6\b/-hydroxycortisol, our results suggest that the extent of possible changes in these parameters would be small.
KW - Chlorophenothane--effects-;
KW - Phenylbutazone--and 6\b/-hydroxycortisol-;
KW - Hydroxycortisol--6\b/--;
KW - Toxicity, environmental--chlorophenothane--effects, of intensive occupational exposure, on phenylbutazone and 6\b/-hydroxycortisol metabolism, in humans;
KW - Metabolism--phenylbutazone--and 6\b/-hydroxycortisol, in humans, effect of intensive occupational exposure to DDT;
KW - Metabolism--hydroxycortisol--6\b/-, and phenylbutazone, effect of intensive occupational exposure to DDT;
KW - Blood levels--chlorophenothane--in exposed factory workers;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1732&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Gatti, Richard A.
AU - Good, Robert A.
T1 - Aging, immunity, and malignancy.
JO - Geriatrics
JF - Geriatrics
Y1 - 1970/09//
VL - 25
IS - 9
M3 - Article
SP - 158
EP - 168
SN - 0016867X
N1 - Accession Number: 15806821; Gatti, Richard A. 1; Good, Robert A. 2; Source Information: Sep1970, Vol. 25 Issue 9, p158; Number of Pages: 11p; Illustrations: 1 Diagram; Document Type: Article; Full Text Word Count: 6253
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=15806821&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Moten, L.;
T1 - Quantitative determination of chromium in triphenylmethane color additives by atomic absorption spectroscopy
CT - Quantitative determination of chromium in triphenylmethane color additives by atomic absorption spectroscopy
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 916
EP - 922
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4180; Language: English; Chemical Name: Chromium--7440-47-3; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Chromium--analysis-;
KW - Triphenylmethane--dyes-;
KW - Dyes--analysis--quantitative determination of chromium in triphenylmethane color additives by atomic absorption spectroscopy;
KW - Spectrometry--atomic absorption--dyes, chromium analysis in triphenylmethane color additives;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4180&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yates, R. L.;
AU - Wenninger, J. A.;
T1 - Constituents of olibanum oil: sesquiterpene hydrocarbons
CT - Constituents of olibanum oil: sesquiterpene hydrocarbons
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 941
EP - 948
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4172; Language: English; References: 18; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Pharmacognosy; Abstract Author: Douglas L. Thompson
N2 - The purpose of this work is to characterize more fully the sesquiterpene hydrocarbons of commercial olibanum oil. Column chromatography, silver nitrate adduction, distillation, and preparative GLC were used to isolate and purify the constituents. Most components were identified by their IR spectra. In some cases NMR spectra were used for identification. GLC retention values and isolation data are presented in table format for the 27 isolated constituents.
KW - Olibanum oil--constituents-;
KW - Oils--olibanum--constituents, sesquiterpenes;
KW - Sesquiterpenes--constituents--olibanum oil;
KW - Hydrocarbons--sesquiterpene--constituents of olibanum oil;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4172&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wenninger, J. A.;
AU - Yates, R. L.;
T1 - High resolution infrared spectra of some naturally occurring sesquiterpene hydrocarbons. II. Second series
CT - High resolution infrared spectra of some naturally occurring sesquiterpene hydrocarbons. II. Second series
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 949
EP - 963
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4173; Language: English; References: 26; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - Twenty-four high resolution IR spectra of naturally occurring sesquiterpene hydrocarbons are presented. Compounds were isolated from essential oils and purified by GLC techniques. The purity of each compound was checked by capillary column GLC. Infrared spectra of the following compounds are included: aromadendrene, allo-aromadendrene, cis-alpha-bergamotene, trans-beta-bergamotene, cis-alpha-bisabolene, trans-alpha-bisabolene, alpha2-bisabolene, cis-gamma-bisabolene, beta-cadinene, beta1-cadinene, alpha-calacorene, chamazulene, beta-chamigrene, cubenene, alpha-himachalene, beta-himachalene, longicyclene, longifolene, alpha-muurolene, gamma-muurolene, gamma-pathcoulene, epi-beta-santalene, selina-4,11-diene, and ylangene.
KW - Sesquiterpenes--natural--analysis, high resolution IR spectra;
KW - Spectrometry--infrared--high resolution spectra of some naturally occurring sesquiterpene hydrocarbons;
KW - Hydrocarbons--sesquiterpenes--natural, high resolution IR spectra;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4173&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chen, J.-Y. T.;
AU - Dority, R. W.;
T1 - Contamination control in infrared microanalysis
CT - Contamination control in infrared microanalysis
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 978
EP - 986
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-3799; Language: English; References: 3; Journal Coden: JANCA2; Section Heading: Pharmaceutical Technology; Pharmaceutical ChemistryDrug Analysis; Abstract Author: Douglas L. Thompson
N2 - Sources of contamination are identified in infrared microanalysis of chemical isolates, and means of control are discussed. Infrared spectra illustrating typical examples of contamination are presented. It was concluded that the chemist must remain constantly aware that problems of contamination will occur in extraction and isolation of microgram or less quantities of chemical compounds to complicate IR and other characterization techniques. However, most contamination problems can be minimized, if not eliminated, by careful chemical practice and good housekeeping, i.e., by paying close attention to quality and quantity of solvents and reagents used, by keeping the instrument, glassware, and apparatus clean, and by using care in sample handling.
KW - Contamination--analysis--micro-, infrared, identification;
KW - Analysis--micro---infrared, sources of contamination identified;
KW - Control--contamination--in IR microanalysis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-3799&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Iverson, J. L.;
T1 - Fatty acid composition of cod liver oil determined by urea fractionation and modified programmed temperature gas chromatography
CT - Fatty acid composition of cod liver oil determined by urea fractionation and modified programmed temperature gas chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1074
EP - 1079
AD - Division of Food and Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4174; Language: English; Chemical Name: Cod liver oil--8001-69-2; References: 33; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - The object of this investigation was to determine more precisely the order in which marine oil fatty acid esters form urea complexes and to apply gas chromatography techniques to elucidate the presence of trace constituents in cod liver lipids. Esters of fatty acids in marine oils, with similar GLC retention times, are concentrated in separate fractions by a proposed urea fractionation procedure. Esters which are present at the ppm. level and are normally hidden under major peaks can then be detected. By modified programmed temperature gas chromatographic techniques, it is possible to detect trace amounts of the short and long chain fatty acids. Accurate identifications are assured by the correlation of fatty acid structure with the preferential order in which they form complexes and retention times before and after hydrogenation. Cod liver oil was found to contain 130 fatty acids. Most of the esters present in trace amounts are predominately C20 to C34 acids which have not been previously reported.
KW - Cod liver oil--analysis-;
KW - Acids--fatty--in cod liver oil, analysis using urea fractionation procedure;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheppard, A. J.;
AU - Hubbard, W. D.;
T1 - Comparison of gas-liquid chromatographic and chemical methods for quantitative determination of the menadione and menadione sodium bisulfite content of pharmaceutical products.
CT - Comparison of gas-liquid chromatographic and chemical methods for quantitative determination of the menadione and menadione sodium bisulfite content of pharmaceutical products.
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1093
EP - 1096
AD - Division of Nutrition, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4183; Language: English; Chemical Name: Menadione--58-27-5; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A collaborative study was conducted to compare the N.F. XII method and a GLC method for quantitatively determining menadione in pharmaceutical products. Ten collaborating laboratories analyzed 6 pharmaceuticals encompassing tablets, capsules, and a liquid. Menadione is extracted with diethyl ether from ground tablets; capsules are opened and the contents are emptied into the ether along with the capsule parts. After filtration and removal of the ether, the residue is redissolved in n-hexane. The menadione sodium bisulfite injectable is transferred to a separatory funnel and extracted with chloroform and sodium hydroxide, evaporated to dryness, and redissolved in n-hexane. The data indicate that, overall, the N.F. analysis is subject to a larger variation than the GLC analysis. An analysis of variance was made on the results from the 1, 5, and 10 mg. levels. There were no statistically demonstrable differences (P \GT/ 0.05) between the average results as given by the 2 methods for these 3 pairs of samples. There was no statistically demonstrable difference (P \GT/ 0.05) in the precision of the 2 methods at the 1, 5, and 10 mg. levels. Also, the analytical time for sample preparation and determination is considerably shorter for the GLC method than for the N.F. method. Because of the large coefficients of variation apparent in this collaborative study, it is recommended that additional studies be carried out.
KW - Menadione--analysis-;
KW - Menadione--sodium bisulfite-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4183&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ment, W. M.;
AU - Marino, V. S.;
T1 - Sterochemical composition of d- and l-amphetamine mixtures by thermal analysis of the benzoyl derivatives
CT - Sterochemical composition of d- and l-amphetamine mixtures by thermal analysis of the benzoyl derivatives
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1097
EP - 1099
AD - Food and Drug Administration, 1560 E. Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 7-4184; Language: English; Chemical Name: Amphetamine--300-62-9; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A procedure for the thermal analysis of the benzoyl derivative of amphetamine is presented, which enables rapid determination of the sterochemical composition of d- and l-amphetamine mixtures with 5% accuracy and requires as little as 5 mg. of the amphetamine salt. Identification of the predominant isomer and confirmation of the isomeric ratio estimation are made by the addition to the sample derivative of an equal amount of standard amphetamine benzoyl derivative of opposite isomeric composition in order to form the amphetamine racemate, which is then analyzed by a second melting range measurement. Melting ranges are determined with the aid of a microscope equipped with a Kofler hot stage.
KW - Amphetamine--isomers-;
KW - Isomers--amphetamine--d- and l-, thermal analysis of benzoyl derivatives;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4184&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Miller, H. M.;
T1 - Separation of trisulfapyrimidines by partition column chromatography
CT - Separation of trisulfapyrimidines by partition column chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1100
EP - 1102
AD - Food and Drug Administration, 433 W. Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 8-0056; Language: English; Trade Name: Trisulfapyrimidines; Generic Name: Sulfonamides; Chemical Name: Sulfamethazine--57-68-1 Sulfamerazine--127-79-7 Sulfadiazine--68-35-9; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A column partition method for the separation of the trisulfapyrimidines (sulfamethazine and sulfamerazine with sulfadiazine) has been developed and studied collaboratively. The sulfas are separated on a 0.1N KHCO\IF/3 \BS/column and eluted with various organic solvents. Three different samples gave fair results with an overall standard deviation of 2.58%. Difficulties were encountered with the 1-butanol used as a solvent and with the Celite. Further work is needed to correct this problem.
KW - Sulfamethazine--combination, sulfamerazine, sulfadiazine-;
KW - Sulfamerazine--combination, sulfamethazine, sulfadiazine-;
KW - Sulfadiazine--combination, sulfamethazine, sulfamerazine-;
KW - Sulfonamides--triple--analysis, column partition;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-0056&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Newton, J. M.;
T1 - GLC determination of nikethamide in injections
CT - GLC determination of nikethamide in injections
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1103
EP - 1105
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 7-4185; Language: English; Chemical Name: Nikethamide--59-26-7; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A GLC method for the direct determination of nikethamide in injections uses a KCl thermionic detector which is sensitive to nitrogen-containing compounds. As little as 1 ng. nikethamide is detected. The proposed method was compared to the N.F. XII method on various commercially prepared samples; the results are in good agreement.
KW - Nikethamide--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4185&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dow, M. L.;
AU - Grant, R. C.;
T1 - Study of the AOAC chromatographic procedure for reserpine tablets
CT - Study of the AOAC chromatographic procedure for reserpine tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/09/01/
VL - 53
IS - Sep
SP - 1106
EP - 1109
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 7-4186; Language: English; Chemical Name: Reserpine--50-55-5; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A modified dimethyl sulfoxide column chromatographic procedure was used to analyze uncoated reserpine tablets representing 108 formulations from 60 drug manufacturers. Changes in the original method (Barken and Kunze) were required because of interferences from excipients; these changes involved column and sample preparation. The standard deviations of the modified procedure were 1.54% of declared (ultraviolet assay) and 0.90% for declared (colorimetric assay) at the 0.25 mg./tablet level.
KW - Reserpine--analysis-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=7-4186&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2005-10464-014
AN - 2005-10464-014
AU - Eisinger, Richard A.
T1 - Use of Deception.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1970/09//
VL - 25
IS - 9
SP - 878
EP - 878
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 2005-10464-014. Partial author list: First Author & Affiliation: Eisinger, Richard A.; United States Public Health Service, National Clearinghouse for Smoking and Health, Arlington, VA, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Deception; Experimental Instructions; Experimental Psychology; Methodology; Values. Minor Descriptor: Experimental Ethics. Classification: General Psychology (2100). References Available: Y. Page Count: 1. Issue Publication Date: Sep, 1970. Copyright Statement: American Psychological Association. 1970.
AB - Comments on 'Deception in psychological research' by J. Seeman (see record [rid]1970-07542-001[/rid]). Certainly, a number of legitimate arguments exist for the reduction and/or elimination of deception in psychological experimentation. However, employed by an ethical scientist, the use of deceit in psychological experimentation can meaningfully contribute to the accumulation of 'wisdom' Seeman cherishes so. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - deception in psychological research
KW - frequency & pragmatic complications & public policy & ethical issues
KW - 1970
KW - Deception
KW - Experimental Instructions
KW - Experimental Psychology
KW - Methodology
KW - Values
KW - Experimental Ethics
KW - 1970
DO - 10.1037/h0020833
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10464-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Maibach, H. I.;
T1 - Perfume phototoxicity
CT - Perfume phototoxicity
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1970/09/17/
VL - 21
IS - Sep 17
SP - 695
EP - 715
SN - 00379832
AD - Dermal Toxicity Branch, Division of Toxicology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-2685; Language: English; Chemical Name: Bergapten--484-20-8 Bergamot oil--8007-75-8; References: 21; Journal Coden: JSCCA5; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - A study on the phototoxic effects of components of oil of bergamot, in humans and animals, is presented. A Hanovia #OQ#OQInspectolite'' provided the radiation source in both human and animal studies. The emission spectrum of one of these radiation sources was measured using a Perkin-Elmer monochromator with a strip chart and tape recorders. Coumarins and furocoumarins from oil of bergamot were isolated and tested for phototoxicity on human subjects. The human studies were performed by tape stripping the forearm to glistening. The agent (0.05 ml.) was applied to the stripped area (5 x 12 cm.), allowed to remain undisturbed for 5 minutes, and then irradiated with the Inspectolite for 40 minutes at a distance of 8-10 cm. The arm was examined at 24 and 48 hours. Results showed that phototoxicity, consisting of erythema, edema, and sometimes vesiculation, was easily obtained on stripped skin with oil of bergamot, the complete coumarin-psoralen fraction, and those portions which contained bergapten. Animal studies were conducted in a similar manner, except that the hair was removed by clipping and the skin was generally not stripped. When all the data on man and animals were considered, it was concluded that bergapten is the only signficant phototoxic component of oil of bergamot. Since this is the case, the photobiologic effects of bergamot would more appropriately be termed bergapten phototoxicity, rather than the commonly used #OQ#OQberloque dermatitis.''
KW - Bergapten--toxicity-;
KW - Bergamot oil--toxicity studies-;
KW - Toxicity studies--bergamot oil--on phototoxic effects, in humans and animals;
KW - Toxicity--bergapten--bergamot oil constituent, cause of phototoxicity, in humans and animals;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-2685&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Harper, L. O.;
AU - Burrell, R. G.;
AU - Lapp, N. L.;
AU - Morgan, W. K. C.;
T1 - Allergic alveolitis due to pituitary snuff
CT - Allergic alveolitis due to pituitary snuff
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/10/01/
VL - 73
IS - Oct
SP - 581
EP - 584
SN - 00034819
AD - Appalachian Laboratory for Occupational Respiratory Diseases, P. O. Box 4292, Bureau of Occupational Safety and Health, U.S. Public Health Service; and the Departments of Medicine and Microbiology, West Virginia University School of Medicine; Morgantown, West Virginia 26505
N1 - Accession Number: 7-4253; Language: English; References: 6; Journal Coden: AIMEAS; Section Heading: Adverse Drug Reactions
N2 - A patient had allergic alveolitis due to pituitary snuff. Specific precipitating antibodies to the snuff were demonstrated. The condition is characterized initially by an alveolitis but in many instances progresses to irreversible pulmonary fibrosis. The patient's pulmonary function and chest film became normal. Improvement may have been related to the use of steroids.
KW - Pituitary--snuff-;
KW - Drugs, adverse reactions--pituitary--snuff, allergic alveolitis;
KW - Allergies--pituitary--snuff, allergic alveolitis;
KW - Toxicity--pituitary--snuff, allergic alveolitis;
KW - Steroids--allergic alveolitis--due to pituitary snuff, therapy;
KW - Snuff--pituitary--adverse reactions, allergic alveolitis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brooks, G. F.;
AU - Buchanan, T. M.;
AU - Bennett, J. V.;
T1 - Tetanus toxoid immunization of adults: a continuing need
CT - Tetanus toxoid immunization of adults: a continuing need
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1970/10/01/
VL - 73
IS - Oct
SP - 603
EP - 606
SN - 00034819
AD - Special Pathogens Section, Bacterial Diseases Branch, Epidemiology Program, National Communicable Disease Center, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333
N1 - Accession Number: 8-0082; Language: English; References: 6; Journal Coden: AIMEAS; Section Heading: Sociology, Economics and Ethics
N2 - In recent years in the United States, tetanus has become a disease primarily of adults; there were about 5 times more tetanus deaths in the 35 years and older age group than for persons 1 to 34 years of age. The mean age at death, excluding neonates, has risen from 25 years in previous years to over 50 years in the late 1960's. Data strongly suggest the need for improved immunization of adults. A schedule for such immunization is provided.
KW - Tetanus toxoids--immunization-;
KW - Immunization--tetanus toxoids--adults, continuing need;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
AU - Peel, L. F.
T1 - Antibody Production in the Bullfrog (Rana catesbeiana .
JO - Immunology
JF - Immunology
Y1 - 1970/10//
VL - 19
IS - 4
M3 - Article
SP - 539
EP - 550
SN - 00192805
AB - Serum antibody was found by radioimmunoelectrophoresis (RIEP) in thirty-one of thirty-five bullfrogs (BF) immunized with one of four protein antigens. Rabbit γ globulin (RGG) and hen egg albumin were the best antigens, whereas human serum albumin and bovine serum albumin induced a less consistent immune response. Although a IgM to IgG sequence of antibody production usually was detected with RGG as antigen, a similar sequence was infrequent with the other antigens and the initial response was usually a IgG antibody. IgM antibody was detected in the serum for a prolonged interval (>100 days) and precipitating quantities of IgG antibody were found more than 1 year after antigen inoculation. As measured by haemagglutination, the IgM antibody was routinely inactivated by mercaptoethanol (ME) treatment and IgG antibody was frequently inactivated by ME, although it still had antigen binding capacity by RIEP. IgG hemagglutinins, which were resistant to ME treatment, were found in some sera obtained from BF after booster injections of antigen. Immunoelectrophoretic examination of normal or immune BF sera revealed a prominent precipitin line of slow γ-mobility which did not bind 131I-labelled antigen but did bind 59Fe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - BULLFROG
KW - ANTIGENS
KW - PRECIPITIN reaction
KW - IMMUNITY
KW - ADMINISTRATION of drugs
N1 - Accession Number: 13360207; Coe, J.E. 1; Peel, L. F. 1; Source Information: Oct70, Vol. 19 Issue 4, p539; Subject: IMMUNOGLOBULINS; Subject: BULLFROG; Subject: ANTIGENS; Subject: PRECIPITIN reaction; Subject: IMMUNITY; Subject: ADMINISTRATION of drugs; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Williams, P. A.;
AU - Kenner, C. T.;
T1 - Acetonitrile-diatomaceous earth column for corticosteroids
CT - Acetonitrile-diatomaceous earth column for corticosteroids
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/10/01/
VL - 59
IS - Oct
SP - 1472
EP - 1476
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas
N1 - Accession Number: 8-1509; Language: English; References: 15; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - This paper reports a new column partitioning chromatographic procedure which effectively traps the corticosteroid in an acetonitrile layer on a diatomaceous earth column while interferences are removed by washing with n-heptane. There is no significant difference in precision between the proposed procedure and the normal precision of the determinative methods. Results on typical pharmaceutical preparations, some of which show evidence of extensive decomposition, are given. Numerous tables are included.
KW - Steroids, cortico---chromatography--column partition chromatographic procedure;
KW - Chromatography--steroids, cortico---column partition chromatographic procedure;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Edwards, C. C.;
T1 - Medical devices and their regulation
CT - Medical devices and their regulation
JO - Med. Res. Eng.
JF - Med. Res. Eng.
Y1 - 1970/10/01/
VL - 9
IS - Oct-Nov
SP - 3
EP - 4
AD - Office of the Commissioner of Food and Drugs, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 9-0283; Language: English; Publication Type: Guest Editorial; Section Heading: Legislation, Laws and Regulations; Abstract Author: Anne W. Hatch
N2 - A new body of statutory law which can be clearly distinguished from the approach presently applied to drugs is needed in the field of medical devices. The proposed legislation should be shaped with suggestions from the industry, since the bulk of expertise lies outside of the FDA. Devices will probably be divided into 3 classes: (1) those which require scientific review prior to public use; (2) devices which should be subject to certain specific standards; and (3) devices proven safe and effective through long use and experience.
KW - Devices--laws--proposed, FDA Commissioner's viewpoint;
KW - Food and Drug Administration (U.S.)--devices--laws, proposed, FDA Commissioner's viewpoint;
KW - Laws--devices--FDA Commissioner's viewpoint on proposed legislation;
KW - Legislation--devices--proposed, FDA Commissioner's viewpoint;
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DP - EBSCOhost
DB - ipa
ER -
TY -
AU - Dohner, V. Alton1
T1 - Drugs Are Not the Problem.
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1970/11//
Y1 - 1970/11//
VL - 36
IS - 3
CP - 3
M3 - Article
SP - 25
EP - 28
SN - 0013127X
AB - The article focuses on drug education programs in schools in the U.S. In the schools, drugs cannot be isolated as a separate course. Drug education must be incorporated into health education and preferably into education for family living. It should start in kindergarten and be interwoven continuously into the curriculum through the twelfth grade. These courses should help children grow to a healthy maturity as intellectually, socially and sexually secure individuals. High school students will be ready for more on the psychology, physiology, biochemistry, and pharmacology of drugs, sexuality, etc. Discussions here should be on value judgments, why certain behavior patterns develop, and alternatives to various types of behavior. Development of meaningful programs for the prevention of drug misuse and abuse is a multidisciplined problem. To some observers it means the development of a totally new concept of interpersonal relations in American society. It also means the alleviation of social, racial, and economic inequalities. It means developing a way of life wherein individuals and humanism are valued more than technology and materialism.
KW - Curricula (Courses of study)
KW - Drug abuse -- Prevention
KW - Educational programs
KW - High school students -- Conduct of life
KW - Health education
KW - United States
N1 - Accession Number: 18858693; Authors: Dohner, V. Alton 1; Affiliations: 1: Chief, Pulmonary Disease Division, United States Public Health Service Hospital, Seattle, Washington.; Subject: Drug abuse -- Prevention; Subject: Educational programs; Subject: High school students -- Conduct of life; Subject: Health education; Subject: Curricula (Courses of study); Subject: United States; Number of Pages: 4p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
TY - GEN
AU - Tanner, J. T.;
AU - Lambert, J. P. F.;
AU - Simpson, R. E.;
T1 - Neutron activation analysis program of the Food and Drug Administration
CT - Neutron activation analysis program of the Food and Drug Administration
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/11/01/
VL - 53
IS - Nov
SP - 1140
EP - 1144
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1677; Language: English; References: 9; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - This paper summarizes the neutron activation analysis (NAA) program of the Food and Drug Administration (FDA), with emphasis on the rapid analyses performed to date. Activation analysis is a rapid and sensitive method of trace element analysis applicable to a large variety of samples. For the most part the method is nondestructive; however, for highest sensitivity, chemical separations are usually required. For about 4 years the FDA has applied NAA to various samples of foods, drugs, and biological materials. Elements such as vanadium, selenium, and mercury have been determined at the nanogram level with little interference from the matrix. Possibly more important than interest in specific element determinations themselves is utilization of the elements or element profiles as indices of required information. Thus, in several forensic applications the authenticity of drugs and food items has been evaluated through the characteristic gamma ray spectral signatures. It was concluded that due to its freedom from reagent and laboratory contamination, independence of matrix effects, and rapidity of analysis, NAA is ideally suited for the analysis of trace and major elements in complex substances such as food and drugs.
KW - Neutron activation analysis--Food and Drug Administration (U.S.)--program;
KW - Food and Drug Administration (U.S.)--analysis--neutron activation, program;
KW - Elements--trace--and major, neutron activation analysis, FDA program;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jeffus, M. T.;
AU - Elkins, J. S.;
AU - Kenner, C. T.;
T1 - Determination of mercury in biological materials
CT - Determination of mercury in biological materials
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/11/01/
VL - 53
IS - Nov
SP - 1172
EP - 1175
AD - Food and Drug Administration, 3032 Bryan Street, and Department of Chemistry, Southern Methodist University, Dallas, Texas 75222
N1 - Accession Number: 8-1707; Language: English; Chemical Name: Mercury--7439-97-6; References: 8; Journal Coden: JANCA2; Section Heading: Drug Metabolism and Body Distribution
N2 - Mercury in biological samples is determined by digestion in nitric acid, sulfuric acid, and permanganate, followed by reduction and aeration for measurement by atomic absorption at room temperature. The average recovery is 95.8% with a standard deviation of 13.3%. The standard deviation, calculated from the difference between duplicates of 23 samples, is 0.063 mcg. mercury, which represents 9.4% of the average value of the samples. The method is simple and requires approximately 4 hours for completion. Mercury can be confirmed by adsorption on gold foil after maximum absorbance has been obtained during aeration.
KW - Mercury--analysis-;
KW - Metabolism--mercury--analysis, in biological materials;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hundley, H. K.;
AU - Underwood, J. C.;
T1 - Determination of total arsenic in total diet samples
CT - Determination of total arsenic in total diet samples
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/11/01/
VL - 53
IS - Nov
SP - 1176
EP - 1178
AD - Food and Drug Administration, 1009 Cherry Street, Kansas City, Missouri 64106
N1 - Accession Number: 8-1678; Language: English; Chemical Name: Arsenic--7440-38-2; References: 9; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - A simple, sensitive, and reproducible procedure was investigated for the determination of total arsenic in composite food samples. Samples are dry ashed in the presence of magnesium oxide and magnesium nitrate, and arsenic is evolved from an acid solution as its hydride. The arsine is reacted with silver diethyldithiocarbamate to give a red complex that is measured photometrically. The absorbance of this complex is proportional to arsenic over a wide range of concentrations (1-20 mcg. arsenic). The method presented is sensitive to 0.05 ppm. (1 mcg./20 g.) product.
KW - Arsenic--analysis-;
KW - Food--analysis--for total arsenic content;
KW - Analysis--arsenic--in food;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Langham, W. S., Jr.;
T1 - Determination of oxygen and carbon dioxide in medicinal gas mixtures by gas-solid chromatography
CT - Determination of oxygen and carbon dioxide in medicinal gas mixtures by gas-solid chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/11/01/
VL - 53
IS - Nov
SP - 1264
EP - 1267
AD - Food and Drug Administration, 1521 W. Pico Blvd., Los Angeles, California 90015
N1 - Accession Number: 8-1698; Language: English; Chemical Name: Oxygen--7782-44-7 Carbon dioxide--124-38-9 Helium--7440-59-7; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A gas-solid chromatographic method is presented for the analysis of oxygen, oxygen-helium, and oxygen-carbon dioxide mixtures. The method utilizes a 16' Porapak Q chromatographic column, hydrogen carrier gas, and a thermal conductivity detection system. It is applicable to the analysis of nitrogen, helium, argon, carbon monoxide, and nitrous oxide. Dry ice conditions are required for the oxygen analysis; carbon dioxide is determined at ambient temperatures. Details for the assembly of a suitable chromatograph and a procedure for sampling gas cylinders are presented. Samples of medicinal gases were analyzed by the proposed method and by the Orsat absorption method. The results by both methods were in good agreement.
KW - Oxygen--analysis-;
KW - Carbon dioxide--analysis-;
KW - Helium--combination, oxygen-;
KW - Gases--medicinal--mixtures, analysis by gas-solid chromatography;
KW - Chromatography--gas-solid--analysis, in medicinal gas mixtures;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dale, W. E.;
AU - Miles, J. W.;
AU - Gaines, T. B.;
T1 - Quantitative method for determination of DDT and DDT metabolites in blood serum
CT - Quantitative method for determination of DDT and DDT metabolites in blood serum
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1970/11/01/
VL - 53
IS - Nov
SP - 1287
EP - 1292
AD - Technical Development Laboratories, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Savannah, Georgia
N1 - Accession Number: 8-1708; Language: English; Trade Name: DDT; Generic Name: Chlorophenothane; Chemical Name: Chlorophenothane--50-29-3; References: 20; Journal Coden: JANCA2; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - A new method for the extraction and determination of DDT (chlorophenothane) and related materials in blood was developed. Rats were given a single oral dose of \SU/14\BS/C-labeled DDT, and it was demonstrated by parallel gas chromatographic and radiometric measurements that in vivo-introduced DDT and related materials could not be removed quantitatively from serum by simple hexane extraction. Pretreatment of the serum with equal volumes of formic acid released the binding of DDT and DDT metabolites and permitted the extraction of these materials with n-hexane, yielding 95% recovery. When applied to sera of men from the general population and of men who had been exposed to DDT for more than 10 years in a manufacturing plant, this method gave consistently higher results than did the simple hexane extraction method.
KW - Chlorophenothane--blood levels-;
KW - Metabolism--chlorophenothane--analysis, blood levels, in rats and humans;
KW - Blood levels--chlorophenothane--analysis, in rats and humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Spectrophotofluorometric determination of mestranol in oral contraceptive tablets
CT - Spectrophotofluorometric determination of mestranol in oral contraceptive tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1970/11/01/
VL - 59
IS - Nov
SP - 1648
EP - 1649
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education, and Welfare, Los Angeles, California 90015
N1 - Accession Number: 8-2159; Language: English; Chemical Name: Mestranol--72-33-3; References: 23; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - A rapid, reliable fluorometric method has been developed for assaying 17\a/-ethynylestradiol 3-methyl ether (mestranol) in some oral contraceptive tablets. The method is sensitive (0.8-1.0 mcg./ml.) and applicable to single-tablet analyses. The accuracy under the conditions studied was 1.29% and the precision ranged from 0.896 to 1.73%.
KW - Mestranol--analysis-;
KW - Analysis--mestranol--in oral contraceptive tablets, spectrophotofluorometric determination;
KW - Contraceptives, oral--tablets--spectrophotofluorometric determination of mestranol;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Johnson, K. T.;
AU - Hepler, C. D.;
AU - Gallardo, J. P. B.;
T1 - Particulate contamination in vials of sterile dry solids
CT - Particulate contamination in vials of sterile dry solids
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1970/12/01/
VL - 27
IS - Dec
SP - 968
EP - 976
SN - 00029289
AD - Pharmacy Department, U. S. Public Health Service Hospital, Baltimore, Maryland
N1 - Accession Number: 8-0312; Language: English; Chemical Name: Penicillin G--61-33-6 Chloramphenicol--56-75-7 Sodium chloride--7647-14-5; References: 26; Journal Coden: AJHPA9; Section Heading: Pharmaceutical Technology; Pharmaceutics
N2 - This paper reports research concerning detection, measurement and counting of particulate contamination found in vials of dry, buffered potassium penicillin G for injection from 3 manufacturers, in vials of dry sterile chloramphenicol sodium succinate from 2 manufacturers, and a preliminary study of the effect of freezing and of sodium chloride-benzyl alcohol diluent on buffered potassium penicillin G for injection. Using a membrane filtration technique followed by microscopic examination and counting of particles retained on the filter, significant differences were found in particle counts, but not size distribution, among manufacturers of both products investigated. Freezing or sodium chloride-benzyl alcohol diluent had no effect with penicillin G. Lot-to-lot similarity in particle counts was observed with one product. Recommendations are given for ways to reduce the number of particles which might reach the patient. The advantages of a pharmacy-operated, centralized reconstitution service are emphasized.
KW - Penicillin G--potassium-;
KW - Chloramphenicol--sodium succinate-;
KW - Sodium chloride--and alcohols, benzyl-;
KW - Particles--injections--contamination, in vials of sterile dry solids;
KW - Injections--particles--contamination, in vials of sterile dry solids;
KW - Contamination--injections--particles, in vials of sterile dry solids;
KW - Vials--particles--contamination, in containers of sterile dry solids;
KW - Freezing--effects--lack, on buffered potassium penicillin G for injection;
KW - Temperature--freezing--effects, lack, on buffered potassium penicillin G for injection;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jacqueline J.
AU - Burke, Allyn D.
T1 - The effectiveness of the Charters', scrub and roll methods of toothbrushing by professionals in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1970/12//
VL - 78
IS - 7
M3 - Article
SP - 459
EP - 463
SN - 0029845X
AB - The effectiveness of the Charters' , scrub, and roll methods of toothbrushing by professional dental personnel in removing plaque was studied in 60 United States Army recruits. An interaction between method of brushing and brusher was found, indicating that no one method was clearly most effective in removing plaque. One brusher removed significantly more plaque with the Charters' method than with the roll method, whereas the other brusher obtained a significantly greater reduction in plaque with the scrub method than with either the Charters' or the roll methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL plaque
KW - DENTAL deposits
KW - DENTAL personnel -- United States
KW - MEDICAL personnel
KW - UNITED States
N1 - Accession Number: 16615062; Frandsen, Asger M. 1; Barbano, Joseph P. 2; Suomi, John D. 2; Chang, Jacqueline J. 2; Burke, Allyn D. 3; Source Information: 1970, Vol. 78 Issue 7, p459; Subject: DENTAL plaque; Subject: DENTAL deposits; Subject: DENTAL personnel -- United States; Subject: MEDICAL personnel; Geographic Terms: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1972-25184-001
AN - 1972-25184-001
AU - Trites, David K.
AU - Galbraith, Frank D.
AU - Sturdavant, Medelyne
AU - Leckwart, John F.
T1 - Influence of nursing-unit design on the activities and subjective feelings of nursing personnel.
JF - Environment and Behavior
JO - Environment and Behavior
JA - Environ Behav
Y1 - 1970/12//
VL - 2
IS - 3
SP - 303
EP - 334
CY - US
PB - Sage Publications
SN - 0013-9165
SN - 1552-390X
N1 - Accession Number: 1972-25184-001. Partial author list: First Author & Affiliation: Trites, David K.; U.S. Public Health Service, Washington, D.C. Release Date: 19720901. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hospitals; Nurses; Physicians. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 32. Issue Publication Date: Dec, 1970.
AB - Performed intensive comparisons of the effect of radial, double-corridor, and single-corridor nursing units on the activities and feelings of nursing personnel, using multiple linear regression methods to remove as many extraneous factors as possible from comparisons. The radial design was found to be superior to the double corridor, and superior to the single corridor in most instances. Nursing personnel on radial units traveled significantly less than on other units; time saved in travel was converted into more time spent with patients; most of the nursing staff preferred working on radials; and there was less staff absenteeism with radial units. Results of a related study indicated that physicians and patients also preferred the radials and the physicians felt the radial design enhanced the quality of patient care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - activities & feelings
KW - radial vs. double- vs. single-corridor nursing units
KW - nursing personnel
KW - 1970
KW - Hospitals
KW - Nurses
KW - Physicians
KW - 1970
DO - 10.1177/001391657000200304
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1972-25184-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Nakada, J.;
T1 - FDA's involvement in IND investigations
CT - FDA's involvement in IND investigations
JO - Drug Inf. Bull.
JF - Drug Inf. Bull.
Y1 - 1971/01/01/
VL - 5
IS - Jan-Jun
SP - 18
EP - 20
AD - Inspection Branch, Philadelphia District, Food and Drug Administration, Philadelphia, Pennsylvania
N1 - Accession Number: 9-1732; Language: English; Section Heading: Legislation, Laws and Regulations; Abstract Author: D. R. Tousignaut
N2 - Regulatory authority, definition and qualifications of the FDA inspector-investigator, inspection of the sponsor (manufacturer), and investigation of clinical pharmacologists are described. The author concludes that the inspector plays an integral and vital role in the total picture of FDA's responsibility in reviewing and acting upon experimental drugs being used on human subjects.
KW - Food and Drug Administration (U.S.)--involvement--in IND investigations;
KW - Drugs, investigational--investigations--IND, FDA's involvement;
KW - Regulations--Food and Drug Administration (U.S.)--involvement, in IND investigations;
KW - Personnel--Food and Drug Administration (U.S.)--definition and qualifications of FDA inspector-investigator;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-1732&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Listook, A. B.;
T1 - Investigational clinical studies
CT - Investigational clinical studies
JO - Food Drug Cosmet. Law J.
JF - Food Drug Cosmet. Law J.
Y1 - 1971/01/01/
VL - 26
IS - Jan
SP - 3
EP - 8
AD - Medical Officer, Scientific Investigation Group, Bureau of Drugs, Food and Drug Administration, Fisher's Lane, Rockville, Maryland
N1 - Accession Number: 9-0072; Language: English; Journal Coden: FDLJAO; Section Heading: Methodology; Abstract Author: Ed Gaia
N2 - It is stated that since clinical studies of investigational drugs constitute the foundation upon which the approval of any NDA (New Drug Application) is based, strict integrity of both the investigator and the sponsor must be maintained. The FDA would rather evaluate a small number of elegantly designed studies than a large number of uncontrolled or testimonial studies. A number of examples of actual cases of drug studies supporting this contention are given. The PMA (Pharmaceutical Manufacturers Association), in conjunction with the FDA, is working to establish testing guidelines, but the data which the clinical investigator produces must be truly adequate, accurate, and complete if the system is to work.
KW - Food and Drug Administration (U.S.)--clinical studies--investigation, design requirements stated;
KW - Drugs, investigational--new drug applications--need for well documented clinical studies, FDA viewpoint;
KW - Clinical studies--drugs, investigational--requirements, FDA viewpoint;
KW - Research--drugs--need for well documented studies, FDA viewpoint;
KW - Methodology--clinical studies--need for well documented studies, FDA viewpoint;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-0072&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rangnekar, M. K.;
T1 - Pharmaceutical industry in India
CT - Pharmaceutical industry in India
JO - Indian Journal of Hospital Pharmacy (India)
JF - Indian Journal of Hospital Pharmacy (India)
Y1 - 1971/01/01/
VL - 8
IS - Jan-Feb
SP - 5
EP - 0
SN - 0019526X
AD - Food and Drug Administration, Maharastra, Bombay, India
N1 - Accession Number: 9-2315; Language: English; Journal Coden: IJHPBU; Section Heading: History; Abstract Author: Anne W. Hatch
N2 - The growth of the pharmaceutical industry in India over the last 20 years, and its relation to the state quality control programs, is recounted. Production capacity and future goals in drug production are outlined in graph form.
KW - Industry, pharmaceutical--India--history, growth, quality control and production capacity;
KW - India--industry, pharmaceutical--history, growth, quality control and production capacity;
KW - History--industry, pharmaceutical--India, growth, quality control and production capacity;
KW - Control, quality--industry, pharmaceutical--India, history;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-2315&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pla, G. W.;
AU - Fritz, J. C.;
T1 - Collaborative study of the hemoglobin repletion test in chicks and rats for measuring availability of iron
CT - Collaborative study of the hemoglobin repletion test in chicks and rats for measuring availability of iron
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 13
EP - 17
AD - Division of Nutrition, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1634; Language: English; Chemical Name: Iron--7439-89-6; References: 6; Journal Coden: JANCA2; Human Indicator: Yes; Section Heading: Biopharmaceutics; Methodology; Abstract Author: Douglas L. Thompson
N2 - A method for the determination of the bioavailability of iron compounds that may be used to fortify foods was described. A hemoglobin repletion method was proposed and studied collaboratively with 8 participating laboratories. The collaborators reported chick or rat data on the availability of supplemental iron from 5 uniform sources. The iron sources used were: ferrous sulfate, ferric orthophosphate, sodium iron pyrophosphate, reduced iron and ferrous carbonate. There was very good agreement between the collaborators. The same iron compound was administered to human volunteers and plasma iron concentrations were determined. Based on the plasma iron concentrations, these samples are ranked in the same order as that found in the chick and rat hemoglobin repletion test. It was recommended that the hemoglobin test for measuring iron availability be adopted as official.
KW - Iron--availability-;
KW - Blood levels--iron--human, correlated to data from hemoglobin repletion test in chicks and rats;
KW - Drugs--availability--methodology, hemoglobin repletion test in chicks and rats measures iron availability;
KW - Metabolism--iron--availability, hemoglobin repletion test in chicks and rats for measuring iron availability;
KW - Methodology--iron availability--hemoglobin repletion test, in chicks and rats;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-1634&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kling, R. E.;
T1 - UV spectrophotometric assay of neostigmine methyl sulfate as the alkaline hydrolysis product, 3-dimethylaminophenol
CT - UV spectrophotometric assay of neostigmine methyl sulfate as the alkaline hydrolysis product, 3-dimethylaminophenol
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 21
EP - 26
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 8-1943; Language: English; Chemical Name: Neostigmine--59-99-4; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A rapid and sensitive method for the assay of neostigmine methylsulfate (NMS) in injectables was developed. Following extraction of phenol and paraben preservatives, NMS is hydrolyzed to 3-dimethylaminophenol, which is determined by UV spectrophotometry. Standard recoveries of NMS from simulated injection solutions containing either: (1) no preservatives, (2) phenol, or (3) parabens, averaged 99.8%. A collaborative study was conducted using 2 simulated injection solutions (one without preservatives, one containing parabens) and 2 commercial injectables (one containing phenol, one containing parabens). Results of 9 collaborators averaged 100.6 1.4 and 102.1 1.5% for the simulated solutions. Results for the 2 commercial preparations averaged 103.0 1.2 and 101.8 1.6% of the respective label declarations. The results of the proposed method are in good agreement with the \IT/U.S.P. \OK/XVII and the new \IT/U.S.P. \OK/XVIII methods.
KW - Neostigmine--methyl sulfate-;
KW - Spectrometry, ultraviolet--neostigmine--methyl sulfate;
KW - Injections--neostigmine--methyl sulfate, UV spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stack, M.;
AU - Rodricks, J. V.;
T1 - Method for analysis and chemical confirmation of sterigmatocystin
CT - Method for analysis and chemical confirmation of sterigmatocystin
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 86
EP - 90
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1949; Language: English; Chemical Name: Sterigmatocystin--10048-13-2; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method is described for the analysis of grain samples for the presence and quantitative estimation of sterigmatocystin, a toxic and carcinogenic mold metabolite. Initial extraction with acetonitrile-water (9:1) containing KCl is followed by partition of the extract first against hexane and then against CHCl\IF/3\BS/, and, if needed, silica gel column chromatography. This sequence provides an extract in which the sterigmatocystin can be estimated by fluorescence intensity comparison on TLC plates against a pure sterigmatocystin standard. Visualization of the sterigmatocystin on the TLC plates is enhanced by an AlCl\IF/3 \BS/spray reagent. After preparative TLC, the identity of sterigmatocystin is confirmed by formation of an acetate derivative and of a derivative formed by treating the suspected extract with aqueous acid.
KW - Sterigmatocystin--analysis-;
KW - Chromatography--sterigmatocystin--column and TLC;
KW - Carcinogens--sterigmatocystin--analysis, in grains, column chromatography and TLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stoloff, L.;
AU - Nesheim, S.;
AU - Yin, L.;
AU - Rodricks, J. V.;
AU - Stack, M.;
AU - \ET/;
T1 - Multimycotoxin detection method for aflatoxins, ochratoxins, zearalenone, sterigmatocystin, and patulin
CT - Multimycotoxin detection method for aflatoxins, ochratoxins, zearalenone, sterigmatocystin, and patulin
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 91
EP - 97
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1950; Language: English; Chemical Name: Zearalenone--17924-92-4 Sterigmatocystin--10048-13-2 Patulin--149-29-1; References: 19; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method was developed for detection of aflatoxins B\IF/1\BS/, B\IF/2\BS/, G\IF/1\BS/, and G\IF/2\BS/, ochratoxins A and B and their ethyl esters, zearalenone, sterigmatocystin, and patulin. The method is based on selective extraction with acetonitrile-water, defatting with isooctane, and removal of water-soluble components by transfer of the mycotoxins to chloroform. The method was applied to corn, barley, oats, and wheat. The detection limits achieved are not as low as can be attained with the analytical procedures for the individual mycotoxins, but are low enough to be useful in a screening procedure.
KW - Aflatoxin--derivatives-;
KW - Zearalenone--analysis-;
KW - Sterigmatocystin--analysis-;
KW - Patulin--analysis-;
KW - Mycotoxins--analysis--selective extraction with acetonitrile-water;
KW - Ochratoxins--analysis--selective extraction with acetonitrile-water;
KW - Analysis--mycotoxins--selective extraction with acetonitrile-water;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yin, L.;
AU - Campbell, A. D.;
AU - Stoloff, L.;
T1 - Method for detection of aflatoxins B\IF/1 \BS/and B\IF/2 \BS/in toasted cottonseed meal
CT - Method for detection of aflatoxins B\IF/1 \BS/and B\IF/2 \BS/in toasted cottonseed meal
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 102
EP - 105
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1952; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Aflatoxin--B\IF/1 \BS/and B\IF/2\BS/-;
KW - Analysis--aflatoxin--B\IF/1 \BS/and B\IF/2 \BS/in toasted cottonseed meal;
KW - Cottonseed--meal--toasted, detection of aflatoxin B\IF/1 \BS/and B\IF/2;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Munns, R. K.;
AU - Holland, D. C.;
T1 - Determination of mercury in fish by flameless atomic absorption: a collaborative study
CT - Determination of mercury in fish by flameless atomic absorption: a collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 202
EP - 205
AD - Food and Drug Administration, 20th and California Streets, Denver, Colorado 80202
N1 - Accession Number: 8-2132; Language: English; Chemical Name: Mercury--7439-97-6; References: 18; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - A collaborative study for the analysis of total mercury in fish is reported. The method is based upon a measurement of the volatilized mercury vapor by flameless atomic absorption. The fish muscle is digested with nitric-sulfuric-perchloric acids. The mercury (Hg\SU/++\BS/) is reduced with stannous chloride-hydroxylamine and then volatilized at room temperature in a stream of air. The air is pumped through a gas cell where the mercury vapor is measured by atomic absorption at 253.7 nm. Nine laboratories participated in the study. An overall mercury recovery of 83.5% and a standard deviation of 0.066 were obtained.
KW - Mercury--analysis-;
KW - Spectrometry--atomic absorption--flameless, mercury analysis in fish;
KW - Food--contamination--mercury, in fish, analysis, flameless atomic absorption spectrometry;
KW - Contamination--food--mercury, in fish, analysis, flameless atomic absorption spectrometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-2132&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hobin, N. K.;
T1 - Determination of pure color in commercial samples of D&C Red No. 30
CT - Determination of pure color in commercial samples of D&C Red No. 30
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/01/01/
VL - 54
IS - Jan
SP - 215
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-1953; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - D&C Red No. 30--analysis-;
KW - Dyes--D&C Red No. 30--analysis, commercial samples;
KW - Analysis--D&C Red No. 30--commercial samples;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Garth, M. A.;
AU - Bryant, H.;
AU - Kramer, J.;
AU - Kirshbaum, A.;
T1 - Survey of a laboratory building for airborne antibiotics
CT - Survey of a laboratory building for airborne antibiotics
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/01/01/
VL - 60
IS - Jan
SP - 63
EP - 67
SN - 00223549
AD - National Center for Antibiotics and Insulin Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 9-0076; Language: English; References: 5; Journal Coden: JPMSAE; Section Heading: Environmental Toxicity; Abstract Author: D. R. Tousignaut
N2 - A survey was performed to determine if antibiotic dust was being disseminated throughout a 6-story building which houses the laboratories of the National Center for Antibiotics and Insulin Analysis (NCAIA) on the second floor. The study was divided into 3 phases. The first was a passive fallout test intended to determine the incidence, if any, of antibiotic dust in representative areas of the building. The second was a vacuum filtration of air in areas in which positive results were found in the first phase, other than NCAIA laboratories. In the third phase, every room of NCAIA was monitored for antibiotic fallout, and then quantitative determinations were made of antibiotics per volume of air in those rooms found positive. Results of this study showed that, outside of the actual laboratories of NCAIA, the incidence of antibiotic contamination of the air was negligible. In the immediate areas where antibiotics were physically handled, 0.012 unit of penicillin and 0.0185 mcg. of chlortetracycline per cubic foot of air were detected. Therefore, persons in this building not testing antibiotics are not exposed to them by way of the atmosphere. Analysts testing antibiotics are exposed to a minimal degree.
KW - Antibiotics--contamination--air, in building with laboratories handling antibiotics, study;
KW - Contamination--air--in building with laboratories handling antibiotics, study for antibiotics;
KW - Air--contamination--in building with laboratories handling antibiotics, study for antibiotics;
KW - Toxicity, environmental--antibiotics--contamination, air, in building with laboratories handling antibiotics, study;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-09476-001
AN - 1974-09476-001
AU - Stewart, Joseph L.
T1 - Cross-cultural studies and linguistic aspects of stuttering.
JF - Journal of the All-India Institute of Speech & Hearing
JO - Journal of the All-India Institute of Speech & Hearing
Y1 - 1971/01//
VL - 2
SP - 1
EP - 6
CY - India
PB - All-India Institute of Speech & Hearing
N1 - Accession Number: 1974-09476-001. Partial author list: First Author & Affiliation: Stewart, Joseph L.; U.S. Public Health Services, Indian Health Service, Washington, D.C. Release Date: 19740501. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Stuttering. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Methodology: Literature Review. Page Count: 6. Issue Publication Date: Jan, 1971.
AB - Examined the universality of stuttering as a problem of human communication by reviewing studies done in different cultural groups. The generalizations obtained were that stuttering did not occur in groups (a) which do not have a term for it in their language and (b) which recognize the developmental nature of child growth and development. Relationships between reduplication and the problem of stuttering, and reduplication and normal fluency, have yet to be examined. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cross-cultural studies
KW - linguistic aspects of stuttering
KW - 1971
KW - Cross Cultural Differences
KW - Stuttering
KW - 1971
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Blair, D. C.;
AU - Barnes, R. W.;
AU - Wildner, E. L.;
AU - Murray, W. J.;
T1 - Biological availability of oxytetracycline HCl capsules: a comparison of all manufacturing sources supplying the United States market
CT - Biological availability of oxytetracycline HCl capsules: a comparison of all manufacturing sources supplying the United States market
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/01/11/
VL - 215
IS - Jan 11
SP - 251
EP - 254
AD - Reprints: Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48104
AD - Office of the Assistant to the Director for Drug Availability, Bureau of Medicine, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 8-3123; Language: English; Trade Name: Terramycin--Dalinmycin--Oxy-Kesso-Tetra--Otetryn--Oxybiocycline--Oxy-Tetrachel; Generic Name: Oxytetracycline; Oxytetracycline; Oxytetracycline; Oxytetracycline; Oxytetracycline; Oxytetracycline; Chemical Name: Oxytetracycline--6153-64-6; Therapeutic Class: (8:12); AHFS Class: Antibiotics oxytetracycline; References: 14; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Biopharmaceutics
N2 - The biological nonequivalency of various brands of oxytetracycline hydrochloride 250 mg. capsules was demonstrated. Capsules produced by the 11 manufacturers supplying the U.S. market were compared in a series of two-way crossover studies with 19 to 22 subjects each. The market products studied were Dalinmycin, Otetryn, Oxybiocycline, Oxy-Kesso-Tetra, Oxy-Tetrachel, and Terramycin. All 11 products met the official certification requirements. Terramycin, the product associated with the most clinical experience, was used as the reference product. The study showed that serum concentrations of 7 of the products were more variable and markedly lower (P[0.005)]than the reference product 2, 3, and 6 hours after ingestion. It was concluded that samples of chemically equivalent oxytetracycline HCl were not biologically equivalent and that the existing in vitro standards for product equivalency are inadequate.
KW - Oxytetracycline--hydrochloride-;
KW - Equivalency--oxytetracycline--hydrochloride, 250 mg. capsules, U.S. market products;
KW - Antibiotics--oxytetracycline--hydrochloride, equivalency, 250 mg. capsules, U.S. market products;
KW - Drugs--availability--oxytetracycline, hydrochloride, 250 mg. capsules, U.S. market products;
KW - Standards--oxytetracycline--hydrochloride, in vitro, inadequate for determining biological availability;
KW - Blood levels--oxytetracycline--hydrochloride, 250 mg. capsules, U.S. market products, demonstrates nonequivalency;
KW - Capsules--oxytetracycline--hydrochloride, 250 mg., U.S. market products, equivalency;
KW - Drugs--clinical effectiveness--oxytetracycline, HCl, 250 mg. capsules, U.S. market products;
KW - Metabolism--oxytetracycline--hydrochloride, blood levels, 250 mg. capsules, U.S. market products;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Berman, S. J.;
AU - Holmes, K. K.;
T1 - Gametocytemia in falciparum malaria: eradication of gametocytemia with primaquine
CT - Gametocytemia in falciparum malaria: eradication of gametocytemia with primaquine
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/01/11/
VL - 215
IS - Jan 11
SP - 291
EP - 292
AD - Department of Medicine, University of Washington Hospital, and the U. S. Public Health Service Hospital, Seattle, Washington
N1 - Accession Number: 8-1882; Language: English; Chemical Name: Primaquine--90-34-6; Therapeutic Class: (8:20); AHFS Class: Plasmodicides primaquine; References: 10; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Following successful treatment of a patient with falciparum malaria which was acquired in Vietnam, persistent gametocytemia was noted. Treatment with primaquine phosphate will eradicate \IT/Plasmodium falciparum \OK/gametocytes, and is recommended for prevention of transmission of falciparum malaria.
KW - Primaquine--phosphate-;
KW - Plasmodicides--primaquine--phosphate, therapy, of gametocytemia, in falciparum malaria patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Borchardt, K. A.;
AU - Richardson, J. A.;
T1 - Human plasma and the antibacterial effect of peritoneal dialysis solutions
CT - Human plasma and the antibacterial effect of peritoneal dialysis solutions
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1971/01/23/
VL - 1
IS - Jan 23
SP - 205
EP - 206
SN - 09598146
AD - Public Health Service Hospital, San Francisco, California 94118
N1 - Accession Number: 8-3664; Language: English; References: 6; Journal Coden: BMJOAE; Section Heading: Microbiology
N2 - The influence of human plasma on the antibacterial effect of solutions for peritoneal dialysis was studied. The solutions contained 43 meq./liter of either acetate or lactate as the source of base. Enough pooled human plasma was added to half of each solution to give a total concentration of a gram of protein/liter. The numbers of viable organisms from 15 clinical isolates each of \IT/Staphylococcus aureus, Escherichia coli, \OK/and \IT/Pseudomonas \OK/species were counted before and after incubation in the 4 solutions. Numbers of viable \IT/S. aureus \OK/and \IT/E. coli \OK/diminished consistently after incubation in all 4 solutions, but the greatest decreases occurred in the acetate solution which contained no plasma. Plasma abolished the greater antibacterial effect of acetate on these organisms. Differences between numbers of viable \IT/Pseudomonas \OK/species after incubation in the 4 solutions were not significant. The diffusion of substances from plasma into dialysis fluids during peritoneal dialysis, therefore, may abolish the greater antibacterial effect of solutions made with acetate rather than lactate.
KW - Plasma--human--effects, on antibacterial activity of peritoneal dialysis solutions containing either acetate or lactate as base;
KW - Solutions--dialysis--peritoneal, acetate or lactate base, effects of human plasma on antibacterial activity;
KW - Dialysis--peritoneal--solutions, acetate or lactate base, effects of human plasma on antibacterial activity;
KW - Acetates--solutions--dialysis, peritoneal, antibacterial activity affected by human plasma;
KW - Lactates--solutions--dialysis, peritoneal, antibacterial activity affected by human plasma;
KW - Drug interactions--plasma and peritoneal dialysis solutions--antibacterial activity of dialysate affected;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3664&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Abrutyn, E.;
AU - Gangarosa, E.;
AU - Forrest, J.;
AU - Mosely, W. H.;
T1 - Cholera in a vaccinated American: immunological response to vaccination and disease
CT - Cholera in a vaccinated American: immunological response to vaccination and disease
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/02/01/
VL - 74
IS - Feb
SP - 228
EP - 231
SN - 00034819
AD - National Communicable Disease Center, Health Services and Mental Health Administration, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia
N1 - Accession Number: 8-1626; Language: English; References: 11; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Judith A. Kepler
N2 - A case of cholera occurred in an American physician exposed in East Pakistan 6 months after primary immunization and 3 months after a booster inoculation for cholera. Serologic tests were run before and after immunization, as well as during the course of illness.
KW - Cholera vaccines--immunization-;
KW - Immunization--cholera--lack, in vaccinated man;
KW - Toxicity--cholera vaccines--immunity, lack, in vaccinated man;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pocurull, D. W.;
AU - Gaines, S. A.;
AU - Mercer, H. D.;
T1 - Survey of infectious multiple drug resistance among Salmonella isolated from animals in the United States
CT - Survey of infectious multiple drug resistance among Salmonella isolated from animals in the United States
JO - Appl. Microbiol.
JF - Appl. Microbiol.
Y1 - 1971/02/01/
VL - 21
IS - Feb
SP - 358
EP - 362
AD - Division of Veterinary Research, Food and Drug Administration, Beltsville, Maryland 20705
N1 - Accession Number: 8-4088; Language: English; References: 22; Journal Coden: APMBAY; Section Heading: Microbiology
N2 - Salmonella cultures were obtained from outbreaks of animal disease from 37 states and one territory. They were screened for resistance to 11 antimicrobial drugs. Of the 1,251 strains studied, 935 were resistant to one or more of these agents. The 3 most common resistance patterns were: ampicillin, dihydrostreptomycin, sulfamethoxypyridazine, tetracycline; ampicillin, dihydrostreptomycin, sulfamethoxypyridazine; dihydrostreptomycin, sulfamethoxypyridazine, tetracycline. Resistance transfer was demonstrated on 267 multiply resistant cultures, of which 181 were able to transfer all or part of their resistance pattern to a drug-sensitive recipient.
KW - Resistance--salmonellae--isolated from animals in U.S., survey of infectious multiple drug resistance;
KW - Salmonellae--isolated from animals in U.S.--survey of infectious multiple drug resistance;
KW - Anti-infective agents--resistance--salmonellae, isolated from animals in U.S., survey of infectious multiple drug resistance;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lawson, C. L.
AU - Slagle, James R.
AU - Farrell, Carl D.
T1 - Experiments in Automatic Learning for a Multipurpose Heuristic Program.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 91
EP - 99
SN - 00010782
AB - An automatic learning capability has been developed and implemented for use with the MULTIPLE (MULTIpurpose Program that LEarns) heuristic tree-searching program, which is presently being applied to resolution theorem-proving in predicate calculus. MULTIPLE's proving program (PP) uses two evaluation functions to guide its search for a proof of whether or not a particular goal is achievable. Thirteen general features of predicate calculus clauses were created for use in the automatic learning of better evaluation functions for PP. A multiple regression program was used to produce optimal coefficients for linear polynomial functions in terms of the features. Also, automatic data-handling routines were written for passing data between the learning program and the proving program, and for analyzing and summarizing results. Data was generally collected for learning (regression analysis) from the experience of PP. A number of experiments were performed to test the effectiveness and generality of the learning program. Results showed that the learning produced dramatic improvements in the solutions to problems which were in the same domain as those used for collecting learning data. Learning was also shown to generalize successfully to domains other than those used for data collection. Another experiment demonstrated that the learning program could simultaneously improve performance on problems in a specific domain and on problems in a variety of domains. Some variations of the learning program were also tested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER programming
KW - MATHEMATICAL analysis
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - MULTIVARIATE analysis
KW - CALCULUS -- Software
KW - adaptive
KW - artificial intelligence
KW - automatic learning
KW - heuristic
KW - learning
KW - LISP
KW - multiple regression
KW - problem-solving
KW - resolution
KW - self-modifying
KW - theorem-providing
KW - tree-searching
N1 - Accession Number: 5221545; Lawson, C. L.; Slagle, James R. 1; Farrell, Carl D. 2; Affiliations: 1: Stanford Artificial Intelligence Project, Stanford University, Stanford, California.; 2: Division of Computer Research and Technology, National Institutes of Health, Public Health Service.; Issue Info: Feb1971, Vol. 14 Issue 2, p91; Thesaurus Term: COMPUTER programming; Thesaurus Term: MATHEMATICAL analysis; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: MULTIVARIATE analysis; Subject Term: CALCULUS -- Software; Author-Supplied Keyword: adaptive; Author-Supplied Keyword: artificial intelligence; Author-Supplied Keyword: automatic learning; Author-Supplied Keyword: heuristic; Author-Supplied Keyword: learning; Author-Supplied Keyword: LISP; Author-Supplied Keyword: multiple regression; Author-Supplied Keyword: problem-solving; Author-Supplied Keyword: resolution; Author-Supplied Keyword: self-modifying; Author-Supplied Keyword: theorem-providing; Author-Supplied Keyword: tree-searching; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 9p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Slagle, James R.
AU - Lee, Richard C. T.
T1 - Application of Game Tree Searching Techniques to Sequential Pattern Recognition.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 103
EP - 110
SN - 00010782
AB - A sequential pattern recognition (SPR) procedure does not test all the features of a pattern at once. Instead, it selects a feature to be tested. After receiving the result of that test, the procedure either classifies the unknown pattern or selects another feature to be tasted, etc. Medical diagnosis is an example of SPR. In this paper the authors suggest that SPR be viewed as a one-person game played against nature (chance). Virtually all the powerful techniques developed for searching two-person, strictly competitive game trees can easily be incorporated either directly or by analogy into SPR procedures. In particular, one can incorporate the "miniaverage backing-up procedure" and the "gamma procedure," which are the analogues of the minimax backing-up procedure and the alpha-beta procedure," respectively. Some computer simulated experiments in character recognition ore presented. The results indicate that the approach is promising. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRONIC data processing
KW - COMPUTER software
KW - COMPUTER programming
KW - COMPUTERS in education
KW - INTEGRAL equations
KW - SEQUENTIAL processing (Computer science)
KW - branch-and-bound approach
KW - dynamic programming
KW - game against nature
KW - game tree searching
KW - gamma procedure
KW - miniaverage backing-up procedure
KW - optimal solution
KW - sequential pattern recognition
N1 - Accession Number: 5221547; Slagle, James R. 1; Lee, Richard C. T. 1; Affiliations: 1: Department of health, Education and Welfare, Division of Computer Research and Technology, Public Health Service. National Institutes of Health, Bethesda, Maryland.; Issue Info: Feb1971, Vol. 14 Issue 2, p103; Thesaurus Term: ELECTRONIC data processing; Thesaurus Term: COMPUTER software; Thesaurus Term: COMPUTER programming; Subject Term: COMPUTERS in education; Subject Term: INTEGRAL equations; Subject Term: SEQUENTIAL processing (Computer science); Author-Supplied Keyword: branch-and-bound approach; Author-Supplied Keyword: dynamic programming; Author-Supplied Keyword: game against nature; Author-Supplied Keyword: game tree searching; Author-Supplied Keyword: gamma procedure; Author-Supplied Keyword: miniaverage backing-up procedure; Author-Supplied Keyword: optimal solution; Author-Supplied Keyword: sequential pattern recognition; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 541519 Other Computer Related Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; Number of Pages: 8p; Illustrations: 13 Diagrams; Document Type: Article
L3 - 10.1145/362515.362562
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Kingma, F. J.;
T1 - New animal drug amendments and implementing regulations
CT - New animal drug amendments and implementing regulations
JO - Food Drug Cosmet. Law J.
JF - Food Drug Cosmet. Law J.
Y1 - 1971/02/01/
VL - 26
IS - Feb
SP - 56
EP - 60
AD - Bureau of Veterinary Medicine, Food and Drug Administration, Rockville, Maryland
N1 - Accession Number: 9-0891; Language: English; Journal Coden: FDLJAO; Section Heading: Legislation, Laws and Regulations
N2 - The consolidation of various regulations relating to new animal drugs into Section 512 (New Animal Drugs) is discussed.
KW - Regulations--New Animal Drugs--amendments leading to Section 512 discussed;
KW - Drugs--veterinary--amendments to regulations resulting in new Section 512 (New Animal Drugs);
KW - Medicine--veterinary--New Animal Drugs, amendments to regulations resulting in new Section 512;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Spann, Melvin L
AU - Willis, Delores D
T1 - A comparative study of a fragmentation vs. a topological coding system in chemical substructure searching
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1971/02//
VL - 11
IS - 1
M3 - Article
SP - 43
EP - 47
SN - 00219576
AB - For the past six years, the food and drug administration has been utilizing a fragmentation coding system for the storage and retrieval of chemical structure information pertaining to investigational and new drug applications. After installation of the chemical abstracts service substructure search system by fda's science information facility, a three month comparative study was conducted using both systems for the retrieval of chemical compound information. This paper presents many of the observations made during this study with particular emphasis on the degree of specificity available inquestion phrasing and the precision in retrieving chemical compounds containing desired substructures.
N1 - Accession Number: ISTA0602192; Spann, Melvin L 1; Willis, Delores D; Affiliations: 1 : Food And Drug Administration, Washington, D.c..; Source Info: February 1971, Vol. 11 Issue 1, p43; Note: Update Code: 0600; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Dow, M. L.;
AU - Kirchhoefer, R. D.;
AU - Brower, J. F.;
T1 - Rapid identification and estimation of gitoxin in digitoxin and digoxin tablets by TLC
CT - Rapid identification and estimation of gitoxin in digitoxin and digoxin tablets by TLC
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/02/01/
VL - 60
IS - Feb
SP - 298
EP - 299
SN - 00223549
AD - Food and Drug Administration, National Center for Drug Analysis, U. S. Department of Health, Education, and Welfare, St. Louis, Missouri 63101
N1 - Accession Number: 9-0641; Language: English; Chemical Name: Gitoxin--4562-36-1 Digitoxin--71-63-6 Digoxin--20830-75-5; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs digitoxin; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Gitoxin--chromatography, thin layer-;
KW - Digitoxin--and digoxin-;
KW - Digoxin--and digitoxin-;
KW - Chromatography, thin layer--gitoxin--rapid identification and estimation, in digitoxin and digoxin tablets;
KW - Cardiac drugs--digitoxin--and digoxin, tablets, rapid identification and estimation of gitoxin, by TLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1971-10074-001
AN - 1971-10074-001
AU - Mintz, Norbett L.
T1 - Patient fees and psychotherapeutic transactions.
JF - Journal of Consulting and Clinical Psychology
JO - Journal of Consulting and Clinical Psychology
JA - J Consult Clin Psychol
Y1 - 1971/02//
VL - 36
IS - 1
SP - 1
EP - 8
CY - US
PB - American Psychological Association
SN - 0022-006X
SN - 1939-2117
N1 - Accession Number: 1971-10074-001. PMID: 5542478 Other Journal Title: Journal of Consulting Psychology. Partial author list: First Author & Affiliation: Mintz, Norbett L.; U.S. Public Health Service, Indian Hosp., Tuba City, Ariz. Other Publishers: American Association for Applied Psychology; Dentan Printing Company; Science Press Printing Company. Release Date: 19710101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Money; Psychotherapeutic Processes; Therapists. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Feb, 1971. Copyright Statement: American Psychological Association. 1971.
AB - Notes that little discussion about fees has appeared in the literature on therapeutic practice, technique, or training. 3 published questionnaire studies concerning basic therapeutic procedures reveal information about therapists' orientations toward fees. While therapists generally are alert to interpret patient remarks and concerns about fees, they often are defensive and doctrinaire about their own attitudes regarding finances. Economic aspects of human interaction and of psychotherapeutic transaction partly have replaced sexual ones as areas which badly need elucidation. Questions are raised about the rationale for various financial practices, and some historical, cultural, and personal factors bearing on the economic aspects of psychotherapy suggested. 3 case examples highlight some effects of these factors on the therapy situation. (20 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - therapeutic process & attitude of therapist about patient fees
KW - 1971
KW - Attitudes
KW - Money
KW - Psychotherapeutic Processes
KW - Therapists
KW - 1971
DO - 10.1037/h0030483
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1971-10074-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1971-30843-001
AN - 1971-30843-001
AU - Matchett, William F.
T1 - Who uses drugs? A study in a suburban public high school.
JF - Journal of School Health
JO - Journal of School Health
JA - J Sch Health
Y1 - 1971/02//
VL - 41
IS - 2
SP - 90
EP - 93
CY - US
PB - American School Health Assn
SN - 0022-4391
SN - 1746-1561
N1 - Accession Number: 1971-30843-001. PMID: 5204222 Partial author list: First Author & Affiliation: Matchett, William F.; Indian Health Service, Navaho Area, Ft. Defiance, Ariz. Release Date: 19711201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Drug Usage; High School Students; Marijuana; Personality. Classification: Social Processes & Social Issues (2900). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Page Count: 4. Issue Publication Date: Feb, 1971.
AB - 81 students in a suburban public high school were studied by a self-administered questionnaire in an attempt to clarify the relationship between some of their subjectively reported attitudes and behavior, and their use of drugs (marihuana, methedrine, amphetamines, or LSD). It was found that there were 2 very different categories of people who were using drugs. 1 group was using them more heavily and seemed to fit the stereotype of an individual on the fringe of society. The other group was apparently only experimenting with drugs or using them socially, and were in fact even more secure, inquisitive, and active than were their nonusing peers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - personality characteristics & attitudes & behavior
KW - suburban high school drug users of marihuana & methedrine & amphetamine & LSD
KW - 1971
KW - Attitudes
KW - Drug Usage
KW - High School Students
KW - Marijuana
KW - Personality
KW - 1971
DO - 10.1111/j.1746-1561.1971.tb03062.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1971-30843-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Buchanan, T. M.;
AU - Brooks, G. F.;
AU - Brachman, P. S.;
T1 - Tularemia skin test\M/325 skin tests in 210 persons: serologic correlation and review of the literature
CT - Tularemia skin test\M/325 skin tests in 210 persons: serologic correlation and review of the literature
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/03/01/
VL - 74
IS - Mar
SP - 336
EP - 343
SN - 00034819
AD - Bacterial Diseases Branch, Epidemiology Program, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia
N1 - Accession Number: 8-2093; Language: English; References: 41; Journal Coden: AIMEAS; Section Heading: Pharmacology
N2 - The tularemia skin test, which can easily be administered and read at the bedside, is a valuable diagnostic tool for the clinician and the epidemiologist. The test, which uses killed detoxified \IT/Francisella tularensis \OK/organisms, is sensitive and specific for tularemia; it becomes positive earlier in the course of illness and is positive longer after infection than the agglutination test. Half of all patients with clinical tularemia are skin test positive the day they present to the physician. The test results in a delayed hypersensitivity reaction read after 48 hours. The test rarely causes a rise in the antibody titer and, once positive, may remain positive for as long as 40 years.
KW - Tests--tularemia--skin, evaluation, in diagnosis of tularemia;
KW - Tularemia--tests--skin, evaluation, as diagnostic agent;
KW - Diagnostic agents--tularemia--tests, skin, evaluation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Change in cholera vaccination requirement
CT - Change in cholera vaccination requirement
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/03/01/
VL - 74
IS - Mar
SP - 447
SN - 00034819
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia
N1 - Accession Number: 8-1753; Language: English; Publication Type: Letters and Comments; Journal Coden: AIMEAS; Section Heading: Sociology, Economics and Ethics; Abstract Author: Judith A. Kepler
N2 - The statement on cholera vaccination issued in December 1970 by the Center for Disease Control is presented. According to this statement, the United States will no longer require cholera vaccinations for travelers coming to the United States from cholera-infected areas.
KW - Cholera vaccines--immunization-;
KW - Immunization--cholera--requirements, for travelers entering U.S.;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bowman, F. W.;
T1 - Quality control of biological indicators
CT - Quality control of biological indicators
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1971/03/01/
VL - 25
IS - Mar-Apr
SP - 78
EP - 79
AD - Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 9-3323; Language: English; References: 3; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology; Microbiology
N2 - The problems arising from the use of biological indicators in lieu of performing the USP sterility test for products sterilized in their final containers are discussed. Guidelines acceptable to regulatory agencies for the satisfactory use of biological indicators are suggested.
KW - Control, quality--sterilization--indicators, biological, guidelines for use and problems;
KW - Sterilization--control, quality--indicators, biological, guidelines for use, and problems;
KW - Tests--sterility--indicators, biological, problems and guidelines;
KW - Spores--indicators--biological, use, problems and guidelines;
KW - Indicators--biological--spores, use, problems and guidelines;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gelber, R.;
AU - Peters, J. H.;
AU - Gordon, R.;
AU - Glazko, A. J.;
AU - Levy, L.;
T1 - Polymorphic acetylation of dapsone in man
CT - Polymorphic acetylation of dapsone in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 1)
SP - 225
EP - 238
SN - 00099236
AD - reprints: Life Sciences Division, Stanford Research Institute, Menlo Park, California 94025
AD - The Leprosy Research Unit, Public Health Service Hospital, San Francisco, California
N1 - Accession Number: 9-0453; Language: English; Trade Name: Avlosulfon; Generic Name: Dapsone; Chemical Name: Dapsone--80-08-0 Isoniazid--54-85-3 Sulfamethazine--57-68-1; Therapeutic Class: (8:16); AHFS Class: Antituberculars isoniazid (8:24); AHFS Class: Sulfonamides sulfamethazine (8:00); AHFS Class: Antileprotic agents dapsone; References: 32; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - The characteristics of the acetylation of dapsone (Avlosulfon) were found to parallel those of isoniazid and sulfamethazine in 19 subjects, thereby establishing the genetic polymorphism for the acetylation of dapsone. This polymorphism was revealed by the distribution of the ratios of the plasma concentration of acetylated to parent drug. The acetylation capacity for dapsone was shown to be a reproducible, individual characteristic. Acetylation of dapsone and deacetylation of monoacetyl dapsone occurred concurrently. Constant plasma ratios of acetylated to parent drug characteristic for the individual were attained immediately after administration of dapsone but only after several hours following administration of monoacetyl dapsone. The available data suggest that acetylation rather than deacetylation is the primary determinant of these ratios. Rates of disappearance of dapsone and monoacetyl dapsone from the plasma were the same regardless of which of the 2 was administered or of the acetylator phenotype of the subject. After dapsone, no differences between rapid and slow acetylators were found in the 24-hour urinary excretion of dapsone and its conjugates hydrolyzed by mild or strong acid treatment. Rapid acetylators excreted significantly more monoacetyl dapsone and its acid-labile conjugates than slow acetylators. Because these compounds accounted for only a very small fraction of the dose, it was not possible to phenotype individuals by these measurements. More dapsone and acid-hydrolyzable conjugates of dapsone were found in 120-hour urine collections after monoacetyl dapsone than after dapsone in both phenotypes.
KW - Dapsone--acetylation-;
KW - Isoniazid--metabolism-;
KW - Sulfamethazine--metabolism-;
KW - Antituberculars--isoniazid--acetylation, in man;
KW - Sulfonamides--sulfamethazine--acetylation, in man;
KW - Polymorphism--dapsone--acetylation, in man;
KW - Acetylation--dapsone--polymorphic, in man;
KW - Blood levels--dapsone--and monoacetyl derivative, in man;
KW - Metabolism--dapsone--acetylation, polymorphic, in man;
KW - Pharmacogenetics--dapsone--acetylation, polymorphic, in man;
KW - Excretion--dapsone--and monoacetyl derivative, effects, genetic factors, in man;
KW - Antileprotic agents--dapsone--acetylation, polymorphic, in man;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Martin, W. R.;
AU - Sloan, J. W.;
AU - Sapira, J. D.;
AU - Jasinski, D. R.;
T1 - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
CT - Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/03/01/
VL - 12
IS - Mar-Apr (Part 1)
SP - 245
EP - 258
SN - 00099236
AD - National Institute of Mental Health, Addiction Research Center, United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 9-0591; Language: English; Chemical Name: Amphetamine--300-62-9 Methamphetamine--537-46-2 Ephedrine--299-42-3 Phenmetrazine--134-49-6 Methylphenidate--113-45-1; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine (28:20); AHFS Class: Central nervous system stimulants methamphetamine (28:20); AHFS Class: Central nervous system stimulants ephedrine (28:20); AHFS Class: Central nervous system stimulants phenmetrazine (28:20); AHFS Class: Central nervous system stimulants methylphenidate; References: 25; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effects of d-amphetamine, d-methamphetamine, phenmetrazine, methylphenidate, and ephedrine, on several physiologic, behavioral, and neurochemical parameters were compared in order to delineate their mode or modes of action in producing subjective reactions. All of these centrally acting sympathomimetic amines increased blood pressure and respiratory rate, produced similar types of subjective changes, and increased the excretion of epinephrine. With regard to these parameters, there was a high concordance between estimates of their relative potencies. The concordance between the potency estimates for the different parameters suggests, but does not prove, that these 5 agents share a common mode of central action. Further, if the peripheral modes of action as elucidated by animal studies are true for man, this study suggests that it is unlikely that their central actions in man are a consequence of the release of norepinephrine in the brain.
KW - Amphetamine--mechanism of action-;
KW - Methamphetamine--mechanism of action-;
KW - Ephedrine--mechanism of action-;
KW - Phenmetrazine--mechanism of action-;
KW - Methylphenidate--mechanism of action-;
KW - Central nervous system stimulants--amphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--methamphetamine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--ephedrine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--phenmetrazine--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Central nervous system stimulants--methylphenidate--mechanism of action, physiologic, subjective and behavioral effects, in man;
KW - Mechanism of action--central nervous system stimulants--physiologic, subjective and behavioral effects, in man;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
T1 - Effects of solvent composition on the column partition chromatography of amines: computer-generated distribution maps
CT - Effects of solvent composition on the column partition chromatography of amines: computer-generated distribution maps
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/03/01/
VL - 54
IS - Mar
SP - 364
EP - 372
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-2993; Language: English; Chemical Name: Dextromethorphan--125-71-3 Chlorpheniramine--132-22-9 Methoxyphenamine--93-30-1 Diphenhydramine--58-73-1 Cyclizine--82-92-8 Promethazine--60-87-7; References: 7; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Pharmaceutics; Abstract Author: Douglas L. Thompson
N2 - A theory regarding the effects of solvent composition on the partition of amines is discussed for both free amines and ion pairs. A computer program is described which prepares distribution maps showing the effects of solvents, pH, and ion pairing. These plots automatically select conditions for the column partition chromatographic separation of amine mixtures. The following drugs are included in this discussion: dextromethorphan, chlorpheniramine, mixtures of the preceeding 2 drugs and mixtures of dextromethorphan with either methoxyphenamine, diphenhydramine, cyclizine or promethazine.
KW - Dextromethorphan--chromatography-;
KW - Chlorpheniramine--chromatography-;
KW - Methoxyphenamine--and dextromethorphan-;
KW - Diphenhydramine--and dextromethorphan-;
KW - Cyclizine--and dextromethorphan-;
KW - Promethazine--and dextromethorphan-;
KW - Chromatography--amines--effects, of solvent composition on column partition, computer-generated distribution maps;
KW - Automation, data processing--computers--program giving distribution maps which show the effects of solvents in column partition chromatography;
KW - Solvents--chromatography--effects, of composition, on column partitioning of amines, demonstrated using computer-generated distribution maps;
KW - Amines--chromatography--column partition, effects of solvent composition, demonstrated using computer-generated distribution maps;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, W. J.;
T1 - Acquired syphilis\M/drugs and blood tests
CT - Acquired syphilis\M/drugs and blood tests
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 1971/04/01/
VL - 71
IS - Apr
SP - 713
EP - 715
SN - 0002936X
AD - Venereal Disease Branch, State and Community Services Division, Center for Disease Control, United States Public Health Service, Atlanta, Georgia
N1 - Accession Number: 9-3634; Language: English; Chemical Name: Penicillin--1406-05-9 Tetracycline--60-54-8; Therapeutic Class: (8:12); AHFS Class: Antibiotics penicillin (8:12); AHFS Class: Antibiotics tetracycline; Journal Coden: AJNUAK; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Jimmie L. Hall
N2 - This article briefly describes the diagnosis and treatment of syphilis. A suitable form of penicillin is the preferred treatment, with tetracycline as an alternate for penicillin-sensitive individuals.
KW - Penicillin--syphilis-;
KW - Tetracycline--syphilis-;
KW - Syphilis--diagnosis--and therapy, discussion;
KW - Antibiotics--penicillin--syphilis, therapy, discussion;
KW - Antibiotics--tetracycline--syphilis, therapy, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-3634&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lenz, P. E.;
T1 - Women, the unwitting carriers of gonorrhea
CT - Women, the unwitting carriers of gonorrhea
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 1971/04/01/
VL - 71
IS - Apr
SP - 716
EP - 719
SN - 0002936X
AD - Venereal Disease Branch, Center for Disease Control, United States Public Health Service, Atlanta, Georgia
N1 - Accession Number: 9-3636; Language: English; Chemical Name: Penicillin--1406-05-9 Tetracycline--60-54-8; Therapeutic Class: (8:12); AHFS Class: Antibiotics penicillin (8:12); AHFS Class: Antibiotics tetracycline; References: 11; Journal Coden: AJNUAK; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Jimmie L. Hall
N2 - This article briefly describes the diagnosis and treatment of gonorrhea. A suitable form of penicillin is the preferred treatment, with tetracycline as an alternate for the penicillin-sensitive individual.
KW - Penicillin--gonorrhea-;
KW - Tetracycline--gonorrhea-;
KW - Gonorrhea--therapy--penicillin, and tetracycline;
KW - Antibiotics--penicillin--gonorrhea, therapy, discussion;
KW - Antibiotics--tetracycline--gonorrhea, therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
AU - Lambert, J. P. F.;
T1 - Determination of zinc in pharmaceutical products by neutron activation analysis
CT - Determination of zinc in pharmaceutical products by neutron activation analysis
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/04/01/
VL - 60
IS - Apr
SP - 592
EP - 594
SN - 00223549
AD - National Center for Antibiotic Analysis and Division of Food Chemistry and Technology, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 9-2260; Language: English; Chemical Name: Zinc--7440-66-6; References: 7; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Nondestructive neutron activation analysis was applied as a rapid, efficient, and specific method for the determination of zinc at either low or major concentration levels in various pharmaceutical products in bulk or dosage forms. This technique yielded results that compare well with more conventional methods and offers decided advantages over them. Tables are included and spectra illustrated.
KW - Zinc--neutron activation analysis-;
KW - Neutron activation analysis--zinc--determination, in pharmaceutical products;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tolbert, C. E.;
AU - Kenner, C. T.;
T1 - Determination of lactate in parenterals containing reducing sugars
CT - Determination of lactate in parenterals containing reducing sugars
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/04/01/
VL - 60
IS - Apr
SP - 596
EP - 599
SN - 00223549
AD - Dallas District, Food and Drug Administration and Department of Chemistry, Southern Methodist University, Dallas, Texas
N1 - Accession Number: 9-1294; Language: English; Chemical Name: Sodium lactate--72-17-3; Therapeutic Class: (40:08); AHFS Class: Alkalinizing agents sodium lactate; References: 12; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - This paper reports the development of an acid-diatomaceous earth column separation of sodium lactate (as lactic acid) from reducing sugars and other interfering substances, using ether as the eluent. The results are satisfactory in the presence of as much as 20% dextrose.
KW - Sodium lactate--analysis-;
KW - Lactates--analysis--in parenterals, containing reducing sugars;
KW - Analysis--lactates--in parenterals, containing reducing sugars;
KW - Alkalinizing agents--sodium lactate--analysis, in parenterals, separation from reducing sugars and other interfering substances;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Robinson, E. P.;
T1 - Pseudomonas aeruginosa contamination of liquid antacids: a survey
CT - Pseudomonas aeruginosa contamination of liquid antacids: a survey
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/04/01/
VL - 60
IS - Apr
SP - 604
EP - 605
SN - 00223549
AD - Food and Drug Administration, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 9-1969; Language: English; Chemical Name: Magnesium hydroxide--1309-42-8; References: 12; Journal Coden: JPMSAE; Section Heading: Pharmacology; Abstract Author: D. R. Tousignaut
N2 - In a recent survey, 279 retail packages of liquid antacid containing magnesium hydroxide as an active ingredient from 11 manufacturers, 21 raw materials, and 6 in-process samples were examined for Pseudomonas aeruginosa. Eighty-five of the finished bottles (30.5%) and 2 in-process samples (33%) were positive. The aerobic plate count ranged from \LT/ 100 to 9,300,000 organisms/g. Nineteen of the total samples (6.8%) including one water sample used as a raw material, were contaminated with coliforms or \IT/Alcaligenes \OK/sp. These samples had an aerobic plate count from \LT/ 100 to 500,000 organisms/g. The high level of contamination with a potential pathogen in commercial antacids from a few manufacturers indicates that a need exists for control of all raw materials (including the manufacture of extracted natural materials such as magnesium hydroxide from sea water), manufacturing processes of nonsterile drugs, and finished product material.
KW - Magnesium hydroxide--antacids-;
KW - Antacids--liquids--containing magnesium hydroxide, contamination, microbiological;
KW - Liquids--antacids--containing magnesium hydroxide, contamination, microbiological;
KW - Contamination--microbiological--antacids, liquid, containing magnesium hydroxide;
KW - Control, quality--antacids--liquids, containing magnesium hydroxide, microbiological contamination;
KW - Pseudomonas aeruginosa--contamination--antacids, liquid, containing magnesium hydroxide;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - CURLEY, AUGUST
AU - SEDLAK, VINCENT A.
AU - GIRLING, EDWARD F.
AU - HAWK, ROBERT E.
AU - BARTHEL, W. F.
AU - PIERCE, PAUL E.
AU - LIKOSKY, WILLIAM H.
T1 - Organic Mercury Identified as the Cause of Poisoning in Humans and Hogs.
JO - Science
JF - Science
Y1 - 1971/04/02/
VL - 172
IS - 3978
M3 - Article
SP - 65
EP - 67
SN - 00368075
AB - Atomic absorption spectrophotometry and neutron activation analysis showed the presence of mercury in organic extracts of seed grain and in tissues of hogs fed the contaminated grain. Mercury was also found in the urine, serum, and cerebrospinal fluid of humans who ate the contaminated pork. Mass spectral analysis confirmed the presence of organic mercury. This paper reports the first documented episode of indirect mercury poisoning in humans in the United States caused by the ingestion of contaminated meat from animals that had consumed mercury in their food supply. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85104441; CURLEY, AUGUST 1; SEDLAK, VINCENT A. 1; GIRLING, EDWARD F. 1; HAWK, ROBERT E. 1; BARTHEL, W. F. 1; PIERCE, PAUL E. 2; LIKOSKY, WILLIAM H. 2; Affiliations: 1: Food and Drug Administration, Atlanta Toxicology Branch, Chamblee, Georgia 30341; 2: Center for Disease Control, Viral Diseases Branch, Epidemiology Program, Atlanta, Georgia 30333; Issue Info: 4/ 2/1971, Vol. 172 Issue 3978, p65; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GRIFFIN, JOE L.
AU - BROSS, IRWIN D. J.
AU - EDWARDS, CHARLES C.
AU - HANDLER, PHILIP
T1 - Environment: Fanning the Flames.
JO - Science
JF - Science
Y1 - 1971/04/30/
VL - 172
IS - 3982
M3 - Article
SP - 425
EP - 427
SN - 00368075
N1 - Accession Number: 85104532; GRIFFIN, JOE L. 1; BROSS, IRWIN D. J. 1; EDWARDS, CHARLES C. 2; HANDLER, PHILIP 3; Affiliations: 1: Roswell Park Memorial Institute, Buffalo, New York 14203; 2: Food and Drug Administration, Washington, D.C. 20204; 3: National Academy of Sciences, Washington, D.C. 20418; Issue Info: 4/30/1971, Vol. 172 Issue 3982, p425; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Karchmer, A. W.;
AU - Friedman, J. P.;
AU - Casey, H. L.;
AU - Shope, T. C.;
AU - Riker, J. B.;
AU - \ET/;
T1 - Simultaneous administration of live virus vaccines
CT - Simultaneous administration of live virus vaccines
JO - Am. J. Dis. Child.
JF - Am. J. Dis. Child.
Y1 - 1971/05/01/
VL - 121
IS - May
SP - 382
EP - 388
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Atlanta, Georgia
N1 - Accession Number: 8-2900; Language: English; References: 25; Journal Coden: AJDCAI; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Jon J. Tanja
N2 - A double-blind controlled study was conducted to evaluate the clinical and serologic responses to the simultaneous administration of 4 live virus vaccines: further attenuated measles, mumps, oral trivalent poliomyelitis, and smallpox. The study involved 221 patients ranging in age between 9 months and 3 years. Following administration of vaccine or placebo, follow-up included visitation by surveillance aides and physician evaluation. The percent of children with temperatures \GE/ 103\DG/F. was significantly greater among recipients of simultaneous vaccines than among those receiving placebo. The clinical and serologic observations reported suggest that the simultaneous administration of these specific 4 vaccines is safe and effective. No evidence of viral interference or increased severity of adverse reactions was noted when the 4 vaccines were given simultaneously.
KW - Measles vaccines--further attenuated-;
KW - Mumps vaccines--administration-;
KW - Polio vaccines--poliomyelitis-;
KW - Smallpox vaccines--administration-;
KW - Immunization--pediatrics--simultaneous administration of further attenuated measles, mumps, oral trivalent poliomyelitis, and smallpox, vaccines;
KW - Pediatrics--vaccines--administration, simultaneous, further attenuated measles, mumps, oral trivalent poliomyelitis and smallpox;
KW - Drug administration--vaccines--simultaneous, further attenuated measles, mumps, oral trivalent poliomyelitis and smallpox, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Vall-Spinosa, A.;
AU - Lester, T. W.;
T1 - Rifampin: characteristics and role in the chemotherapy of tuberculosis
CT - Rifampin: characteristics and role in the chemotherapy of tuberculosis
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1971/05/01/
VL - 74
IS - May
SP - 758
EP - 760
SN - 00034819
AD - reprints: Public Health Service Indian Hospital, 801 Vassar Drive, N.E., Albuquerque, New Mexico 87106
AD - National Jewish Hospital, Denver, Colorado
N1 - Accession Number: 8-2957; Language: English; Chemical Name: Rifampin--13292-46-1; Therapeutic Class: (8:16); AHFS Class: Antituberculars rifampin; References: 12; Journal Coden: AIMEAS; Section Heading: Pharmacology; Investigational Drugs
N2 - The available evidence shows that rifampin rivals isoniazid in effectiveness against infection with Mycobacterium tuberculosis. The toxicity of rifampin and the best way to use it have not yet been established. Pending the results of controlled trials now under way, rifampin should be reserved for retreatment chemotherapy and for cases where drug intolerance prevents the use of current standard regimens.
KW - Rifampin--characteristics and role in chemotherapy of tuberculosis-;
KW - Antituberculars--rifampin--characteristics and role in chemotherapy of tuberculosis, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Read, R. B., Jr.;
AU - Bradshaw, J. G.;
AU - Swartzentruber, A. A.;
AU - Brazis, A. R.;
T1 - Detection of sulfa drugs and antibiotics in milk
CT - Detection of sulfa drugs and antibiotics in milk
JO - Appl. Microbiol.
JF - Appl. Microbiol.
Y1 - 1971/05/01/
VL - 21
IS - May
SP - 806
EP - 808
AD - Division of Microbiology, Food and Drug Administration, Cincinnati, Ohio 45226
N1 - Accession Number: 10-2935; Language: English; Chemical Name: Bacitracin--1405-87-4; References: 5; Journal Coden: APMBAY; Section Heading: Drug Analysis; Abstract Author: Irving S. Rossoff
N2 - A disk assay method is described using Bacillus megaterium ATCC 9855 as a test organism; the method is sensitive to a number of sulfa derivatives and bacitracin undetected by conventional procedures.
KW - Bacitracin--analysis-;
KW - Analysis--bacitracin--sulfonamides, in vitro disk assay, in milk;
KW - Sulfonamides--analysis--in vitro disk assay, in milk;
KW - Analysis--sulfonamides--and bacitracin, in vitro disk assay, in milk;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Spivey Fox, M. R.;
T1 - Essential trace elements
CT - Essential trace elements
JO - FDA Pap.
JF - FDA Pap.
Y1 - 1971/05/01/
VL - 5
IS - May
SP - 8
EP - 4
AD - Minerals Section, Nutritional Sciences Branch, Division of Nutrition, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 8-3416; Language: English; Journal Coden: FDAPAL; Section Heading: Pharmaceutical Chemistry; Pharmaceutical Technology; Abstract Author: Douglas L. Thompson
N2 - The role of the Food and Drug Administration in research, regarding trace elements, is briefly discussed.
KW - Elements--trace--essential, research, role of FDA;
KW - Food and Drug Administration (U.S.)--research--role, essential trace elements;
KW - Nutrition--elements--trace, essential, research, role of FDA;
KW - Research--elements--trace, essential, role of FDA;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Andersen, D. L.;
T1 - GLC determination of methanol in liquids: collaborative study
CT - GLC determination of methanol in liquids: collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 558
EP - 559
AD - Food and Drug Administration, 909 First Avenue, Seattle, Washington 98104
N1 - Accession Number: 8-3217; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A rapid, specific method for methanol in aqueous and nonaqueous liquids was developed and studied collaboratively. The method involves sample dilution with dioxane to approximately 0.4% methanol and injection into a gas chromatograph fitted with a Porapak R column and a flame ionization detector. A collaborative study, with 7 collaborators each reporting on 6 test portions, showed coefficients of variation of 2.7, 2.1, 2.3, 4.2, 1.8, and 3.5.
KW - Methanol--chromatography, gas-;
KW - Chromatography, gas--methanol--in aqueous and nonaqueous liquids;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brunner, C. A.;
T1 - Collaborative study of the analysis of mestranol in combination with norethindrone or norethynodrel
CT - Collaborative study of the analysis of mestranol in combination with norethindrone or norethynodrel
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 590
EP - 592
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3216; Language: English; Chemical Name: Mestranol--72-33-3 Norethindrone--68-22-4 Norethynodrel--68-23-5; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A collaborative study was conducted on the analysis of mestranol in combination with norethindrone or norethynodrel by partition chromatography and UV measurement. The test preparations consisted of 4 samples: a composite of norethindrone commercial tablets and the corresponding synthetic mixture, and a composite of norethynodrel commercial tablets and the corresponding synthetic mixture. Single analyses were performed on each of the samples by 13 collaborators. The average percent recovery was 100.4, 99.9, 98.7, and 101.2% respectively.
KW - Mestranol--combination, norethindrone or norethynodrel-;
KW - Norethindrone--combination, mestranol-;
KW - Norethynodrel--combination, mestranol-;
KW - Analysis--contraceptives, oral--mestranol, combination, norethindrone or norethynodrel, partition chromatography and UV spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Johnson, R. D.;
T1 - Collaborative study of the determination of menadione sodium bisulfite in injections
CT - Collaborative study of the determination of menadione sodium bisulfite in injections
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 593
EP - 595
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 8-3215; Language: English; Chemical Name: Menadione--58-27-5; References: 9; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A chromatographic-UV spectrophotometric method for the determination of menadione sodium bisulfite was subjected to a collaborative study. A sample of the injection is mixed with Celite and placed on a chromatographic column. The column is washed with chloroform; the menadione is eluted with an ammonia-saturated chloroform solution and determined by measuring UV absorbance at 334 nm. Four synthetic sample solutions were sent to 13 collaborators for analysis. The average recoveries of these solutions ranged from 97.5 to 98.4% of added amount and had coefficients of variation ranging from 1.1 to 1.4%.
KW - Menadione--sodium bisulfite-;
KW - Injections--menadione--sodium bisulfite, chromatography, UV spectrometry;
KW - Chromatography--menadione--sodium bisulfite, and UV spectrometry, injections;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lane, J. R.;
T1 - Automated colorimetric determination of phenylephrine hydrochloride in drug formulations. I. Development of the method
CT - Automated colorimetric determination of phenylephrine hydrochloride in drug formulations. I. Development of the method
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 596
EP - 599
AD - National Center for Antibiotic Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3208; Language: English; Chemical Name: Phenylephrine--59-42-7 Zinc--7440-66-6; References: 8; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - An automated colorimetric method for the analysis of phenylephrine is described. Using the AutoAnalyzer, studies were made of different reagent concentrations and reagent volume ratios to satisfy the reaction conditions of the official AOAC method. The debubbler-flowcell design was changed to improve the flow dynamics, and the internal volumes of all unsegmented flow lines were minimized to permit good resolution at fast sampling ratios (50/hr.). Relative standard deviations of less than 0.5% were obtained on multiple determinations of the same solutions. Essentially 100% recovery was obtained on assays of phenylephrine HCl added to simulated nasal solutions. The results of analyses of commercial dosage forms (nasal solutions, sprays and suspensions) containing phenylephrine HCl ranged from 94.2 to 102.0% of the declared values. It was noted that formulations containing zinc interfered with the method.
KW - Phenylephrine--hydrochloride-;
KW - Zinc--interference-;
KW - Colorimetry--phenylephrine--hydrochloride, automated method, including nasal dosage forms;
KW - Dosage forms--phenylephrine--hydrochloride, nasal preparations, automated colorimetry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
T1 - Automated colorimetric determination of phenylephrine hydrochloride in drug formulations. II. Collaborative study
CT - Automated colorimetric determination of phenylephrine hydrochloride in drug formulations. II. Collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 600
EP - 602
AD - National Center for Antibiotic Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3211; Language: English; Chemical Name: Phenylephrine--59-42-7 Tetracycline--60-54-8 Salicylamide--65-45-2 Acetaminophen--103-90-2 Zinc--7440-66-6; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - An automated colorimetric method designed for the analysis of phenylephrine HCl in drug formulations has been submitted to a collaborative study. Five samples, including 2 with known interferences, were sent to 9 collaborators. The results were subjected to statistical evaluation. These show good recovery and a maximum interlaboratory coefficient of variation of 4.5%. It was concluded that the automated colorimetric method was suitable for the analysis of phenylephrine HCl in the absence of tetracycline, acetaminophen, salicylamide, and zinc salts.
KW - Phenylephrine--hydrochloride-;
KW - Tetracycline--interference-;
KW - Salicylamide--interference-;
KW - Acetaminophen--interference-;
KW - Zinc--interference-;
KW - Colorimetry--phenylephrine--hydrochloride, automated, dosage forms;
KW - Dosage forms--phenylephrine--hydrochloride, automated colorimetry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3211&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chu, R.;
T1 - Collaborative study and ion exchange method for the determination of methyldopa, chlorothiazide, and hydrochlorothiazide in drug mixtures
CT - Collaborative study and ion exchange method for the determination of methyldopa, chlorothiazide, and hydrochlorothiazide in drug mixtures
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 603
EP - 608
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 8-3214; Language: English; Chemical Name: Methyldopa--41372-08-1 Chlorothiazide--58-94-6 Hydrochlorothiazide--58-93-5; References: 7; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method for the assay of methyldopa with either chlorothiazide or hydrochlorothiazide was studied collaboratively by 8 laboratories. The method involves the use of AG50-4X, 100-200 mesh H\SU/+ \BS/cation exchange resin to resolve the compounds. The thiazides pass freely through the resin column, while methyldopa is retained and subsequently eluted with 1N methanolic HCl. The components are quantitatively measured by spectrophotometry at 280 (methyldopa), 277 (chlorothiazide), and 270 nm. (hydrochlorothiazide). For the methyldopa-chlorothiazide combination, the overall average recovery for methyldopa was 98.5% with a standard deviation of 2.50; and for the methyldopa-hydrochlorothiazide combination, 96.4% with a standard deviation of 2.30. The average recoveries for chlorothiazide and hydrochlorothiazide were 99.6 (standard deviation of 1.14) and 98.8% (standard deviation of 2.92), respectively.
KW - Methyldopa--combination, chlorothiazide or hydrochlorothiazide-;
KW - Chlorothiazide--combination, methyldopa-;
KW - Hydrochlorothiazide--combination, methyldopa-;
KW - Chromatography--ion exchange--methyldopa, combination, chlorothiazide or hydrochlorothiazide, dosage forms;
KW - Dosage forms--methyldopa, combination, chlorothiazide or hydrochlorothiazide--chromatography, ion exchange;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3214&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, E.;
AU - Sharkey, M. F.;
AU - Levine, J.;
T1 - Assay of ipecac and its preparations. I. Development of the method
CT - Assay of ipecac and its preparations. I. Development of the method
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 609
EP - 613
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3213; Language: English; Chemical Name: Ipecac--8012-96-2 Emetine--483-18-1 Cephaeline--483-17-0; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A partition chromatographic method was developed which quantitatively separates the 2 major ipecac alkaloids emetine and cephaeline. The isolated alkaloids were determined by their UV absorbance at 282 nm. The method was applied to powdered ipecac root, ipecac syrup, and ipecac fluid extract. The results obtained show good precision.
KW - Ipecac--dosage forms-;
KW - Emetine--constituents-;
KW - Cephaeline--constituents-;
KW - Chromatography--partition--ipecac, dosage forms, separation of emetine and cephaeline;
KW - Dosage forms--ipecac--chromatography, partition, separation of emetine and cephaeline;
KW - Powders--ipecac--roots, chromatography, partition, separation of emetine and cephaeline;
KW - Syrups--ipecac--chromatography, partition, separation of emetine and cephaeline;
KW - Extracts--fluid--ipecac, chromatography, partition, separation of emetine and cephaeline;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3213&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sharkey, M. F.;
AU - Smith, E.;
AU - Levine, J.;
T1 - Assay of ipecac and its preparations. II. Collaborative study
CT - Assay of ipecac and its preparations. II. Collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 614
EP - 616
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3212; Language: English; Chemical Name: Ipecac--8012-96-2 Emetine--483-18-1 Cephaeline--483-17-0; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method for the determination of 2 major alkaloids in ipecac syrup and powdered ipecac root was subjected to a collaborative study. A 4-column chromatographic procedure is used for the isolation of emetine and cephaeline, which are measured individually by UV absorption. Two commercial syrups were employed as samples. The powdered root samples were representative of the different ratios of emetine and cephaeline occurring in the different species. The collaborative results were good: standard deviations ranged from 0.024 to 0.066 for the powdered samples and from 1.11 to 2.77 for the syrup samples.
KW - Ipecac--chromatography-;
KW - Emetine--chromatography-;
KW - Cephaeline--chromatography-;
KW - Chromatography--partition--ipecac, syrup and powdered root, separation of emetine and cephaeline;
KW - Syrups--ipecac--chromatography, partition;
KW - Powders--ipecac--roots, chromatography, partition;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3212&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wu, J. Y. P.;
T1 - Collaborative study of the colorimetric determination of progestational steroids in contraceptive tablets
CT - Collaborative study of the colorimetric determination of progestational steroids in contraceptive tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 617
EP - 619
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 8-3209; Language: English; Chemical Name: Norethynodrel--68-23-5 Norethindrone--68-22-4 Medroxyprogesterone--520-85-4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A collaborative study of the AOAC proposed colorimetric method for progestational steroids in oral contraceptive tablets was conducted. In this method a chloroform extract of norethindrone or medroxyprogesterone acetate is treated directly with isonicotinic acid hydrazide to produce a stable color which is measured at 380 nm. A chloroform extract of norethynodrel is isomerized with hydrochloric acid prior to this reaction. Both commercial tablets and simulated tablet mixtures of norethynodrel, norethindrone, and medroxyprogesterone acetate were assayed by the proposed method. Average recoveries of the steroids ranged from 95.30 to 101.91% of the declared amounts of commercial tablets, and 97.77 to 99.20% of the added quantities in simulated samples.
KW - Norethynodrel--colorimetry-;
KW - Norethindrone--colorimetry-;
KW - Medroxyprogesterone--acetate-;
KW - Contraceptives, oral--colorimetry--tablets, and simulated tablet mixtures, collaborative study, progestogen constituents;
KW - Progestogens--colorimetry--tablets, and simulated tablet mixtures, collaborative study;
KW - Tablets--progestogens--colorimetry, collaborative study;
KW - Colorimetry--progestogens--tablets, and simulated tablet mixtures, collaborative study;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3209&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Alber, L. L.;
AU - Overton, M. W.;
AU - Smith, D. E.;
T1 - Gas-liquid chromatographic assay for salicylamide, acetaminophen, and caffeine mixtures, using on-line, computerized real time data acquisition
CT - Gas-liquid chromatographic assay for salicylamide, acetaminophen, and caffeine mixtures, using on-line, computerized real time data acquisition
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/05/01/
VL - 54
IS - May
SP - 620
EP - 624
AD - Food and Drug Administration, 433 W. Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 8-3428; Language: English; Chemical Name: Salicylamide--65-45-2 Acetaminophen--103-90-2 Caffeine--58-08-2; References: 25; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Salicylamide, acetaminophen, and caffeine in drug formulations and in simulated preparations can be separated and quantitatively measured by GLC. Amobarbital and cyclizine are used as internal standards; the 4\DP/ GLC column contains 3% OV-17 on Gas Chrom Q. The signal from the KCl thermionic detector is amplified and fed directly into the analog-to-digital converter of a PDP 12A LINC system computer. Results by the computer are compared to manual peak height measurements for 6 commercial preparations injected in duplicate and to results obtained from a UV procedure. The simulated tablet mixtures contained salicylamide and acetaminophen or these 2 ingredients plus caffeine.
KW - Salicylamide--combination, acetaminophen-;
KW - Acetaminophen--combination, salicylamide-;
KW - Caffeine--combination, salicylamide, acetaminophen-;
KW - Chromatography, gas--analgesics--mixtures, salicylamide, combination, acetaminophen, with and without caffeine, using on-line computerized real time data acquisition;
KW - Dosage forms--analgesics--chromatography, gas, analysis using on-line computerized real time data acquisition;
KW - Automation, data processing--computers--analysis, analgesic mixtures, using on-line computerized real time data acquisition;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3428&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Edwards, C. C.;
T1 - Let's focus on pharmacy's full role in medical care
CT - Let's focus on pharmacy's full role in medical care
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1971/05/01/
VL - 37
IS - May
SP - 38
EP - 40
SN - 00030627
AD - Food and Drug Administration, Department of Health, Education and Welfare, Washington, D.C.
N1 - Accession Number: 10-3188; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacy Practice; Abstract Author: Walter F. Stanaszek
N2 - The role of the pharmacist on the health team is discussed in relation to communications with other health team members and effective surveillance of the patient.
KW - Health care--team--pharmacists, role, discussion;
KW - Pharmacists--health care--team, role, discussion;
KW - Communication--pharmacists--health care, team, role, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3188&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Prosser, A. R.;
AU - Sheppard, A. J.;
T1 - GLC of trimethylsilyl derivatives of pantothenyl alcohol and pantothenates
CT - GLC of trimethylsilyl derivatives of pantothenyl alcohol and pantothenates
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/06/01/
VL - 60
IS - Jun
SP - 909
EP - 912
SN - 00223549
AD - Division of Nutrition, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 10-0392; Language: English; Trade Name: Panthenol--Pantothenyl alcohol; Generic Name: Dexpanthenol; Dexpanthenol; Chemical Name: Dexpanthenol--81-13-0; References: 26; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - A rapid and accurate silylation procedure has been presented which will yield derivatives of all of the pantothenates (calcium pantothenate, pantothenic acid, and sodium pantothenate) and panthenol (dexpanthenol; pantothenyl alcohol). This procedure may also find use as a monitoring device for determining pantothenic acid and its derivatives in the formation or degradation of coenzyme A. Chromatograms are illustrated.
KW - Dexpanthenol--chromatography, gas-;
KW - Pantothenate--calcium-;
KW - Pantothenate--sodium-;
KW - Chromatography, gas--dexpanthenol--trimethylsilyl derivatives;
KW - Chromatography, gas--pantothenate--calcium, and sodium, trimethylsilyl derivatives;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-0392&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ingersoll, J. E.;
T1 - New information on BNDD requirements for controlled substances
CT - New information on BNDD requirements for controlled substances
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1971/06/01/
VL - 37
IS - Jun
SP - 52
EP - 60
SN - 00030627
AD - Bureau of Narcotics and Dangerous Drugs, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 8-4312; Language: English; Journal Coden: PYTMAO; Section Heading: Legislation, Laws and Regulations; Pharmacy Practice; Abstract Author: Walter F. Stanaszek
N2 - Responsibilities of the pharmacist which accompany the new Controlled Substances Act (Comprehensive Drug Abuse Prevention and Control Act) as of May 1, 1971 are discussed in depth. Topics to which the new regulations pertain are: retail dispensing restrictions for Schedule V, symbols and labeling, registration, records and inventory, order forms, prescriptions, emergency dispensing, and drug security and control. A list is included of the Domestic Regional Office addresses of the Bureau of Narcotics and Dangerous Drugs (BNDD) and the areas they serve.
KW - Comprehensive Drug Abuse Prevention and Control Act--requirements--for pharmacists;
KW - Food and Drug Administration (U.S.)--Comprehensive Drug Abuse Prevention and Control Act--responsibilities, of the pharmacist;
KW - Laws--Comprehensive Drug Abuse Prevention and Control Act--responsibilities, of the pharmacist;
KW - Pharmacists--laws--Comprehensive Drug Abuse Prevention and Control Act, responsibilities;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-4312&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1972-31854-001
AN - 1972-31854-001
AU - Miller, Sheldon I.
AU - Schoenfeld, Lawrence S.
T1 - Suicide attempt patterns among the Navajo Indians.
JF - International Journal of Social Psychiatry
JO - International Journal of Social Psychiatry
JA - Int J Soc Psychiatry
Y1 - 1971///Sum 1971
VL - 17
IS - 3
SP - 189
EP - 193
CY - US
PB - Sage Publications
SN - 0020-7640
SN - 1741-2854
N1 - Accession Number: 1972-31854-001. PMID: 5160537 Partial author list: First Author & Affiliation: Miller, Sheldon I.; U.S. Public Health Service, Navajo Area Indian Health Service, Window Rock, Ariz. Release Date: 19721201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Ethnology; Human Sex Differences; Suicide. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 5. Issue Publication Date: Sum 1971.
AB - Studied records of suicides and suicide attempts on the Navajo Reservation to identify high-risk groups. During a 71/2-mo period, 64 attempts, including 8 successful suicides, were reported. There was a tendency for attempts to be made by young females of a modern, nontraditional background. In contrast to other studies, these data show that the frequency, methods, and precipitating events of Navajo suicide attempts do not differ markedly from comparable data derived from non-Indian populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide patterns
KW - age & sex & background
KW - Navajo Indians
KW - 1971
KW - Age Differences
KW - Ethnology
KW - Human Sex Differences
KW - Suicide
KW - 1971
DO - 10.1177/002076407101700303
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1972-31854-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Miller, L. W.;
T1 - Methemoglobinemia associated with well water
CT - Methemoglobinemia associated with well water
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1971/06/07/
VL - 216
IS - Jun 7
SP - 1642
EP - 1643
AD - Epidemiology Program, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Atlanta, Georgia
N1 - Accession Number: 9-0276; Language: English; Chemical Name: Milk--8049-98-7 Water--7732-18-5; References: 12; Journal Coden: JAMAAP; Section Heading: Environmental Toxicity
N2 - A case of infant methemglobinemia associated with milk formula prepared from well water containing excess nitrates occurred in Texas. The existence of numerous rural wells with high nitrate concentrations has been documented in various areas through the United States in the past and again in Texas in 1969. These private wells and certain rural municipal water supplies represent a possible source for cases of methemoglobinemia.
KW - Milk--toxicity-;
KW - Water--toxicity-;
KW - Water--case of infant methemoglobinemia from milk formula prepared from well water containing excess nitrates-;
KW - Food--milk--case of infant methemoglobinemia from milk formula prepared from well water containing excess nitrates;
KW - Toxicity--nitrates--contained in well water, case of infant methemoglobinemia from milk formula;
KW - Nitrates--toxicity--contained in well water, case of infant methemglobinemia from milk formula;
KW - Contamination--water--case of infant methemoglobinemia from milk formula prepared from well water containing excess nitrates;
KW - Toxicity, environmental--nitrates--contained in well water, case of infant methemoglobinemia from milk formula;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-0276&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Heltzer, N. E.;
AU - Smith, J. E.;
AU - Culkin, T. T.;
T1 - Control of sample drugs
CT - Control of sample drugs
JO - Hospitals
JF - Hospitals
Y1 - 1971/06/16/
VL - 45
IS - Jun 16
SP - 97
EP - 99
AD - Public Health Service Hospital, Zuni, New Mexico
N1 - Accession Number: 8-3496; Language: English; References: 3; Journal Coden: HOSIAJ; Section Heading: Pharmacy Practice; Abstract Author: Hugh F. Kabat
N2 - Described is an effective 4-step program of sample drug control which consists of appropriate professional and administrative approval, written regulations providing for sample storage and dispensing by pharmacy, periodic destruction of unwanted sample drugs and continuous monitoring for compliance.
KW - Control--drugs--samples, administrative procedure;
KW - Samples--drugs--control, administrative procedure;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=8-3496&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sikes, R. K.;
AU - Cleary, W. F.;
AU - Koprowski, H.;
AU - Wiktor, T. J.;
AU - Kaplan, M. M.;
T1 - Effective protection of monkeys against death from street virus by post-exposure administration of tissue culture rabies vaccine
CT - Effective protection of monkeys against death from street virus by post-exposure administration of tissue culture rabies vaccine
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1971/07/01/
VL - 45
IS - Jul
SP - 1
EP - 1
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Lawrenceville, Georgia
N1 - Accession Number: 10-2064; Language: English; Language of Summary: fr; References: 12; Journal Coden: BWHOA6; Section Heading: Preliminary Drug Testing
N2 - Three series of experiments on rabies vaccines were carried out on rhesus monkeys using suckling-mouse brain vaccine, rabbit brain vaccine, duck embryo vaccine, and purified, concentrated tissue culture vaccine. The latter was prepared in a human diploid cell strain and inactivated with \b/-propiolactone, and consisted of tissue culture fluid concentrated 200-fold with a final infectivity titer of 10\SU/9.8\BS/ plaque forming units/ ml. before inactivation. In the first 2 series of experiments, several vaccines were tested for relative immunogenicity on a pre-exposure basis. In the third series, a successful model was developed in which a single inoculation of the tissue culture vaccine administered after exposure to rabies virus, with or without accompanying standard doses of antirabies serum, was evaluated as a method of prevention. A single dose of the tissue culture vaccine protected 7 out of 8 monkeys from death by street virus. Homologous or heterologous antirabies serum alone gave poor results. The results indicate great promise for prophylaxis in man with one dose, or perhaps a few doses, of highly concentrated, purified tissue culture vaccine.
KW - Rabies vaccines--effects-;
KW - Immunization--rabies--vaccines, effects, antiviral, in monkeys;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2064&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Martin, W. R.;
AU - Hoeldtke, R.;
T1 - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
CT - Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1971/07/01/
VL - 12
IS - Jul-Aug
SP - 613
EP - 649
SN - 00099236
AD - The National Institute of Mental Health Addiction Research Center, and the United States Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 9-4369; Language: English; Trade Name: CI-572--BAY-4503; Generic Name: Profadol; Propiram; Chemical Name: Profadol--428-37-5 Propiram--15686-91-6; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics GPA-1657 (28:08); AHFS Class: Analgesics and antipyretics profadol (28:08); AHFS Class: Analgesics and antipyretics propiram; References: 29; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Toxicity; Investigational Drugs
N2 - GPA-1657, profadol hydrochloride (CI-572), and propiram fumarate (BAY-4503) are proposed as analgesics of low abuse potential since none will suppress but each will precipitate abstinence in morphine-dependent monkeys. GPA-1657 is not an antagonist in man but a typical morphine-like compound and is judged to have significant abuse potential. Profadol and propiram act as antagonists in man and precipitate abstinence in subjects dependent on 240 mg. of morphine per day. As agonists, profadol and propiram resemble morphine-like rather than nalorphine-like drugs, since both produce morphine-like subjective effects and physical dependence and suppress abstinence in subjects dependent on 60 mg. per day of morphine. Both were judged to have abuse potential. Propiram was judged to have somewhat less abuse potential than profadol, since it produces less euphoria and less physical dependence. The morphine antagonist properties of profadol and propiram are thought to be caused by the fact that they are morphine agonists with less intrinsic activity than morphine.
KW - GPA-1657--toxicity-;
KW - Profadol--hydrochloride-;
KW - Propiram--fumarate-;
KW - Toxicity--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW - Toxicity--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Toxicity--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW - Analgesics and antipyretics--GPA-1657--abuse potential, studies, compared to profadol and propiram, in patients;
KW - Analgesics and antipyretics--profadol--hydrochloride, abuse potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Analgesics and antipyretics--propiram--fumarate, abuse potential, studies, compared to GPA-1657 and profadol, in patients;
KW - Dependence--GPA-1657--potential, studies, compared to profadol and propiram, in patients;
KW - Dependence--profadol--hydrochloride, potential, studies, compared to GPA-1657 and propiram, in patients;
KW - Dependence--propiram--fumarate, potential, studies, compared to GPA-1657 and profadol, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-4369&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jaffee, M.;
AU - Ford, L.;
T1 - Analysis of radiopharmaceuticals
CT - Analysis of radiopharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/07/01/
VL - 54
IS - Jul
SP - 879
EP - 883
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 9-0854; Language: English; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - Some of the activities of chemists engaged in evaluating and selecting methodology for examination of radiopharmaceuticals and the criteria for assessment of their quality are described. Significant problems, as they relate to a regulatory analysis program, and tentative solutions to these problems are discussed. Conclusions and recommendations, based on the results of analysis of selected radiopharmaceutical preparations of commercial origin, are given.
KW - Radiopharmaceuticals--analysis--methodology;
KW - Analysis--radiopharmaceuticals--methodology;
KW - Methodology--radiopharmaceuticals--analysis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-0854&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stricklin, M. C.;
AU - Smith, D. J.;
T1 - Ion exchange method for benztropine mesylate in tablets
CT - Ion exchange method for benztropine mesylate in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/07/01/
VL - 54
IS - Jul
SP - 893
EP - 894
AD - Food and Drug Administration, 50 Fulton St., San Francisco, California 94102
N1 - Accession Number: 8-3205; Language: English; Chemical Name: Benztropine--86-13-5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - In the analytical procedure described, benztropine is retained on a column of sulfonated polystyrene cation resin, then eluted with 250 ml. 1.00 N alcoholic KCl and determined by UV absorption. The recoveries of benztropine from a simulated drug preparation ranged from 99 to 106%. The analysis of 0.5 and 2 mg. benztropine mesylate tablets both gave 101% of the label declaration, respectively.
KW - Benztropine--mesylate-;
KW - Chromatography--ion exchange--benztropine, mesylate, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hamilton, J. L., Jr.;
T1 - Collaborative study of the analysis of acetaminophen and salicylamide in tablets and capsules
CT - Collaborative study of the analysis of acetaminophen and salicylamide in tablets and capsules
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/07/01/
VL - 54
IS - Jul
SP - 895
EP - 899
AD - Food and Drug Administration, 900 Madison Avenue, Baltimore, Maryland 21201
N1 - Accession Number: 8-3427; Language: English; Chemical Name: Acetaminophen--103-90-2 Salicylamide--65-45-2; References: 31; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A column chromatographic procedure has been developed for separating acetaminophen and salicylamide in combination with a variety of other drug ingredients in tablets and capsules. Strongly acidic and basic Celite columns are used to trap acetaminophen and salicylamide, respectively. Quantitation is performed using UV spectrophotometry. Identifications are made by the infrared KBr technique on a portion of the column eluates. A collaborative study of the method was conducted. Average recoveries of 99.45% for acetaminophen and 100.9% for salicylamide were obtained for a synthetic standard mixture. The study also included 3 commercial drug products which were assayed for acetaminophen and salicylamide.
KW - Acetaminophen--and salicylamide-;
KW - Salicylamide--and acetaminophen-;
KW - Dosage forms--acetaminophen--and salicylamide, tablets and capsules, column chromatography;
KW - Dosage forms--salicylamide--and acetaminophen, tablets and capsules, column chromatography;
KW - Chromatography--column, acetaminophen--and salicylamide, in tablet and capsule dosage forms;
KW - Chromatography--column, salicylamide--and acetaminophen, in tablet and capsule dosage forms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cooper, J. F.;
AU - Levin, J.;
AU - Wagner, H. N., Jr.;
T1 - Quantitative comparison of in vitro and in vivo methods for the detection of endotoxin
CT - Quantitative comparison of in vitro and in vivo methods for the detection of endotoxin
JO - J. Lab. Clin. Med.
JF - J. Lab. Clin. Med.
Y1 - 1971/07/01/
VL - 78
IS - Jul
SP - 138
EP - 148
AD - reprints: Bureau of Radiological Health, United States Public Health Service, 12720 Twinbrook Parkway, Rockville, Maryland 20852
AD - Department of Radiological Science [Division]of Nuclear Medicine , and Department of Medicine, The Johns Hopkins Medical Institutions, and Marine Biological Laboratory, Baltimore, Maryland
N1 - Accession Number: 9-1359; Language: English; References: 33; Journal Coden: JLCMAK; Section Heading: Pharmaceutical Technology; Pharmaceutics; Abstract Author: S. Bruce Benson
N2 - This report compares quantitatively the sensitivity to endotoxin of the Limulus (the horseshoe crab) test (in vitro) with pyrogenic response in rabbits (in vivo) using purified lipopolysaccharides of E. coli and Klebsiella and evaluates its use for the detection of endotoxin in short-lived radiopharmaceuticals. The current legally required bioassay for endotoxin in parenteral solutions is based on the pyrogenic effect of bacterial endotoxin in rabbits and is difficult to perform. The Limulus method for the detection of endotoxin is based upon the reaction in vitro between endotoxin and a lysate prepared from amebocytes, the circulating blood cells of Limulus. This assay is rapid, simple, and sensitive and requires only 0.1 ml. of the material being tested. The Limulus test detected 0.001 \mu/g. per milliliter of \IT/E. coli \OK/endotoxin, whereas injection of the same concentration according to the official protocol of the \IT/United States Pharmacopeia \OK/did not result in a pyrogenic response. Similarly, the Limulus test detected 0.0001 \mu/g. per milliliter of Klebsiella endotoxin, although a dose of 0.0006 \mu/g. per kilogram was not pyrogenic in rabbits. There was good correlation between the pyrogenic potency of purified endotoxins of \IT/E. coli \OK/and Klebsiella, as measured by their median-pyrogenic dose and fever index, and the rate of gelation of lysates of Limulus amebocytes. Two preparations of short-lived radiopharmaceutical agents which were pyrogenic produced gelation of amebocyte lysate in less than 15 minutes. The results demonstrated that the Limulus test was approximately 10 times as sensitive to endotoxin as the official pyrogen test. This in vitro assay is a potential alternative test for the detection of bacterial endotoxin in drugs, fluids, and other agents prepared for parenteral administration to human beings.
KW - Endotoxins--analysis--quantitative comparison of in vitro and in vivo methods for detection;
KW - Tests--endotoxins--quantitative comparison of in vitro and in vivo methods for detection;
KW - Radiopharmaceuticals--short-lived--endotoxins, detection, discussion;
KW - Contamination--endotoxins--quantitative comparison of in vitro and in vivo methods for detection;
KW - Pyrogens--tests--endotoxins, using rabbits, quantitative comparison with in vitro method for detection;
KW - Tests--pyrogens--endotoxins, using rabbits, quantitative comparison with in vitro method for detection;
KW - Bacteria--endotoxins--quantitative comparison of in vitro and in vivo methods for detection;
KW - Pharmacopeial standards--pyrogens--tests, endotoxins, using rabbits, quantitative comparison with in vitro method for detection;
KW - Analysis--endotoxins--quantitative comparison of in vitro and in vivo methods for detection;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-1359&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schertel, M. E.;
AU - Sheppard, A. J.;
T1 - Cathode ray polarography of riboflavin, thiamine hydrochloride, and niacinamide content of pharmaceutical preparations
CT - Cathode ray polarography of riboflavin, thiamine hydrochloride, and niacinamide content of pharmaceutical preparations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/07/01/
VL - 60
IS - Jul
SP - 1070
EP - 1074
SN - 00223549
AD - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 9-4004; Language: English; Trade Name: Niacinamide; Generic Name: Nicotinamide; Chemical Name: Riboflavin--83-88-5 Thiamine--59-43-8; References: 10; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - A polarographic method for the determination of riboflavin, thiamine HC1, and niacinamide (nicotinamide) in multivitamin preparations was evaluated. Distinct polarographic waves of the 3 vitamins from single extracts were obtained after adjusting the \IT/p\OK/H to 5.7-6.0. Polarographic results were compared with official chemical analyses. Results indicate that the polarographic method has potential for rapidly screening the vitamin content of multivitamin preparations.
KW - Riboflavin--polarography-;
KW - Nicotinamide--polarography-;
KW - Thiamine--hydrochloride-;
KW - Vitamins--multiple--polarography, cathode ray, of riboflavin, thiamine HC1 and nicotinamide;
KW - Polarography--cathode ray--vitamins, multiple, riboflavin, thiamine HC1 and nicotinamide;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-4004&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bowman, F. W.;
AU - White, M.;
AU - Calhoun, M. P.;
T1 - Collaborative study of aerobic media for sterility testing by membrane filtration
CT - Collaborative study of aerobic media for sterility testing by membrane filtration
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/07/01/
VL - 60
IS - Jul
SP - 1087
EP - 1088
SN - 00223549
AD - National Center for Antibiotic Analysis, Office of Pharmaceutical Research and Testing, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 9-4122; Language: English; References: 6; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Technology
N2 - The U.S.P. XVIII and N.F. XIII (first supplement) have replaced the sterility test medium, fluid Sabouraud, with a soybean-casein digest medium. A collaborative study performed by 12 laboratories showed that soybean-casein digest medium is superior to fluid Sabouraud medium for sterility testing by membrane filtration.
KW - Tests--sterility--membrane filtration, U.S.P. and N.F., replace fluid Sabouraud medium with soybean-casein digest;
KW - Media--soybean-casein digest--replaces fluid Sabouraud for pharmacopeial membrane filtration sterility tests;
KW - Filters--membrane--tests, sterility, soybean-casein digest medium replaces pharmacopeial fluid Sabouraud medium in sterility tests;
KW - Soybean-casein digest--media--tests, sterility, replaces fluid Sabouraud in U.S.P. and N.F.;
KW - Sterility--tests--membrane, filtration, pharmacopeial, U.S.P. and N.F., replace fluid Sabouraud medium with soybean-casein digest;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-4122&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bowman, F. W.;
AU - White, M.;
AU - Lyles, R. L.;
T1 - Microbial contamination of nonsterile antibiotic market samples: a survey
CT - Microbial contamination of nonsterile antibiotic market samples: a survey
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/07/01/
VL - 60
IS - Jul
SP - 1099
EP - 1101
SN - 00223549
AD - National Center for Antibiotic Analysis, Office of Pharmaceutical Research and Testing, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 9-3528; Language: English; References: 15; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Technology
N2 - Nonsterile antibiotic samples on the U.S. market were examined for microbial contamination in a survey that included 261 batches from 38 different manufacturers. All the drugs tested were of acceptable hygienic quality in that their microbial content was minimal and innocuous. A table listing results is included.
KW - Antibiotics--nonsterile--contamination, microbiological, minimal, in market samples;
KW - Contamination--microbiological--antibiotics, nonsterile, minimal, in market samples;
KW - Bacteria--contamination--antibiotics, nonsterile, minimal, in market samples;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - KOLBYE JR., ALBERT C.
T1 - Mercury in Meat.
JO - Science
JF - Science
Y1 - 1971/07/02/
VL - 173
IS - 3991
M3 - Article
SP - 8
EP - 8
SN - 00368075
N1 - Accession Number: 85159727; KOLBYE JR., ALBERT C. 1; Affiliations: 1: Food and Drug Administration, Washington, D.C. 20204; Issue Info: 7/ 2/1971, Vol. 173 Issue 3991, p8; Number of Pages: 1/9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - EDWARDS, CHARLES C.
AU - BAZELL, R. J.
T1 - FDA Action on Blood Poisoning.
JO - Science
JF - Science
Y1 - 1971/07/30/
VL - 173
IS - 3995
M3 - Article
SP - 379
EP - 379
SN - 00368075
N1 - Accession Number: 87562602; EDWARDS, CHARLES C. 1; BAZELL, R. J.; Affiliations: 1: Food and Drug Administration, Rockville, Maryland 20852; Issue Info: 7/30/1971, Vol. 173 Issue 3995, p379; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Menzie, J. W.;
AU - Fortner, C. L.;
AU - Cradock, J. C.;
T1 - Unit-dose system for handling parenteral investigational cancer chemotherapeutic agents
CT - Unit-dose system for handling parenteral investigational cancer chemotherapeutic agents
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1971/08/01/
VL - 28
IS - Aug
SP - 605
EP - 610
SN - 00029289
AD - Patient Care Pharmacy Service, Baltimore Cancer Research Center, NIH, C, NCI, U.S. Public Health Service Hospital, Baltimore, Maryland
N1 - Accession Number: 8-3527; Language: English; References: 3; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - This paper describes the system used for the handling of parenteral investigational cancer chemotherapeutic agents by pharmacists located in a patient care area. The pharmacist prepares a solution of the drug aseptically within a laminar air flow environment and dispenses the preparation directly to the physician in a labeled unit-of-use form (syringe or I.V. bottle). Methods for recording drug usage data are described which serve as a patient medication record and an investigational drug inventory. This system requires a close working relationship between physician and pharmacist. This relationship has greatly enhanced the functioning of a clinical pharmacy program.
KW - Drugs, investigational--antineoplastic agents--injections, unit-dose system, description;
KW - Antineoplastic agents--investigational--injections, unit-dose system, description;
KW - Drug distribution systems--unit-dose--parenteral investigational cancer chemotherapeutic agents, description;
KW - Pharmacy, institutional, hospital--drug distribution systems--unit-dose, parenteral investigational cancer chemotherapeutic agents;
KW - Injections--antineoplastic agents--investigational, unit-dose system, description;
KW - Clinical pharmacy--drug distribution systems--unit-dose, parenteral investigational cancer chemotherapeutic agents;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Key, Marcus M.
AU - Reno, Stanley J.
T1 - OCCUPATIONAL HEALTH PROGRAMS AT THE FEDERAL LEVEL FOR THE NEXT TEN YEARS.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/08//
VL - 61
IS - 8
M3 - Article
SP - 1583
EP - 1585
PB - American Public Health Association
SN - 00900036
AB - This paper offers an historical review, an assessment of the present status, and some indication of the immediate future of federal programs in the field of occupational health. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Health
KW - Environmental health
KW - Occupational medicine
KW - Employees
KW - Medical care
KW - Health promotion
KW - Industrial workers
KW - Work environment
N1 - Accession Number: 24845743; Key, Marcus M. 1; Reno, Stanley J. 1; Affiliations: 1: Bureau of Occupational Safety and Health, Public Health Service; Issue Info: Aug1971, Vol. 61 Issue 8, p1583; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health; Thesaurus Term: Environmental health; Subject Term: Occupational medicine; Subject Term: Employees; Subject Term: Medical care; Subject Term: Health promotion; Subject Term: Industrial workers; Subject Term: Work environment; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Davis, E. B.;
T1 - Biologicals and other drugs distributed by the Center for Disease Control
CT - Biologicals and other drugs distributed by the Center for Disease Control
JO - Hospital Pharmacy (USA)
JF - Hospital Pharmacy (USA)
Y1 - 1971/08/01/
VL - 6
IS - Aug
SP - 4
EP - 1
SN - 00185787
AD - Publications Activities, Laboratory Divison, Center For Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia
N1 - Accession Number: 9-4120; Language: English; References: 1; Journal Coden: HOPHAZ; Section Heading: Pharmaceutical Technology; Abstract Author: K. Richard Knoll
N2 - The Center for Disease Control (CDC) in Atlanta distributes a number of special biologicals through its Immunobiologics Activity (IA), its Epidemiology Program and its Foreign Quarantine Program. The IA, which distributes most of these biologicals, was established in 1965 as a national center for the storage and distribution of certain biological products. The biologicals fall into 6 groups: (1) antitoxins, (2) antivenins (3) globulins and plasmas, (4) parasitic drugs, (5) skin test antigens, and (6) vaccines. Persons may request biologicals by calling the Center. In cases of requests for biologicals that the Center does not supply, inquirers are referred to the proper source. In addition to the supplies at CDC, emergency supplies of 4 of the biologicals are available at CDC's Foreign Quarantine Program stations in 8 major U.S. cities. These biologicals are botulinum horse antitoxin ABE, diphtheria horse antitoxin, pentamidine isethionate and vaccinia immune globulin. A table is included entitled ""Biologicals procured, distributed, and stored by IA, CDC, with information about their source, licensure, and IND application.'' An appendix is entitled ""Consultants qualified to release vaccinia immune globulin."
KW - Centers for Disease Control--discussion--distribution of biologicals and other drugs;
KW - Biologicals--distribution--by Center for Disease Control, discussion;
KW - Drugs--and biologicals--distribution, by Center for Disease Control, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J. B.
T1 - The Immune Response in the Hamster III. SELECTIVE INDUCTION OF CONCOMITANT ANTIBODY FORMATION AND UNRESPONSIVENESS IN THE 7Sγ1- AND 7Sγ2-GLOBULINS WITH SOLUBLE HEN EGG ALBUMIN.
JO - Immunology
JF - Immunology
Y1 - 1971/08//
VL - 21
IS - 2
M3 - Article
SP - 175
EP - 191
SN - 00192805
AB - Synthesis of antibody to hen egg albumin (HEA) was restricted to one of the 7S immunoglobulins (7Sγ1:globulin) when hamsters were inoculated with soluble HEA (HEA-saline). This selective induction occurred regardless of the amount of HEA-saline injected (0.001–5·0 mg) or the route of inoculation. In contrast, HEA in Freund's adjuvants induced synthesis of anti-HEA in both the 7Sγ1 - and 7Sγ2 -globulins, even when as little as 0.1 μg of HEA was used. Repeated inoculations of hamsters with HEA-saline increased or maintained 7Sγ1 antibody, but did not induce anti-HEA synthesis in the 7Sγ2 -globulins. The results of cell transfer experiments indicated that cells from HEA-saline treated hamsters were primed to synthesize 7Sγ1 anti-HEA and were specifically unresponsive for 7Sγ2 anti-HEA synthesis. Selective induction of antibody production and unresponsiveness, concomitantly, within different immunoglobulin classes suggests that different antibody induction mechanisms are utilized by these two immunoglobulin classes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINS
KW - IMMUNOGLOBULINS
KW - HAMSTERS
KW - IMMUNE response
KW - ANTIGENS
N1 - Accession Number: 13480522; Coe, J. B. 1; Source Information: Aug71, Vol. 21 Issue 2, p175; Subject: ALBUMINS; Subject: IMMUNOGLOBULINS; Subject: HAMSTERS; Subject: IMMUNE response; Subject: ANTIGENS; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hirschhorn, Norbert
AU - Greenough III, William B.
T1 - Cholera.
JO - Scientific American
JF - Scientific American
Y1 - 1971/08//
VL - 225
IS - 2
M3 - Article
SP - 15
EP - 21
SN - 00368733
AB - The article discusses about cholera disease. The first outbreak of cholera in 1849 is recalled. It describes the effect of cholera on world health. The organism that causes it and available treatments for those infected are discussed in detail. It further discusses the scientific studies being done to find a specific antidote.
KW - World health
KW - Gram-negative bacterial diseases
KW - Bacterial diseases
KW - Cholera
KW - Vibrio infections
N1 - Accession Number: 21957920; Hirschhorn, Norbert 1; Greenough III, William B. 2; Affiliations: 1: U.S. Public Health Service; 2: John Hopkins University, School of Medicine; Issue Info: Aug1971, Vol. 225 Issue 2, p15; Thesaurus Term: World health; Thesaurus Term: Gram-negative bacterial diseases; Thesaurus Term: Bacterial diseases; Subject Term: Cholera; Subject Term: Vibrio infections; Number of Pages: 7p; Illustrations: 3 Diagrams, 3 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1972-20861-001
AN - 1972-20861-001
AU - Hammerschlag, Carl A.
AU - Astrachan, Boris M.
T1 - The Kennedy airport snow-in: An inquiry into intergroup phenomena.
JF - Psychiatry: Journal for the Study of Interpersonal Processes
JO - Psychiatry: Journal for the Study of Interpersonal Processes
JA - Psychiatry
Y1 - 1971/08//
VL - 34
IS - 3
SP - 301
EP - 308
CY - US
PB - Guilford Publications
SN - 0033-2747
N1 - Accession Number: 1972-20861-001. Other Journal Title: Psychiatry: Interpersonal and Biological Processes. Partial author list: First Author & Affiliation: Hammerschlag, Carl A.; Indian Health Service, Mental Health Branch, Phoenix, Ariz. Other Publishers: Taylor & Francis. Release Date: 19720701. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Collective Behavior; Crises; Interpersonal Interaction. Classification: Social Psychology (3000). Population: Human (10). Page Count: 8. Issue Publication Date: Aug, 1971.
AB - Describes intergroup processes observed by 1 author while he was snowed in at Kennedy Airport for several days in February 1969. The need is stressed for organizations, particularly during crises, to develop facilities for coordinated and effective planning and action. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intergroup processes during Kennedy airport snow-in
KW - 1971
KW - Collective Behavior
KW - Crises
KW - Interpersonal Interaction
KW - 1971
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FAVERO, M. S.
AU - CARSON, L. A.
AU - BOND, W. W.
AU - PETERSEN, N. J.
T1 - Pseudomonas aeruginosa: Growth in Distilled Water from Hospitals.
JO - Science
JF - Science
Y1 - 1971/08/27/
VL - 173
IS - 3999
M3 - Article
SP - 836
EP - 838
SN - 00368075
AB - Pseudomonas aeruginosa can grow relatively fast in distilled water obtained in hospitals and achieve high cell contaminations which remnain stable for long periods of time. Cells grown in distilled water react quite differently to chemical and physical stresses than cells grown in standard laboratory culture miedia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002477; FAVERO, M. S. 1; CARSON, L. A. 1; BOND, W. W. 1; PETERSEN, N. J. 1; Affiliations: 1: Applied Microbiology and Planetary Quarantine Section, Center for Disease Control, Public Health Service, Phoenix, Arizona 85014; Issue Info: 8/27/1971, Vol. 173 Issue 3999, p836; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bryan, Frank L.
AU - Kilpatrick, Edward G.
T1 - CLOSTRIDIUM PERFRINGENS RELATED TO ROAST BEEF COOKING, STORAGE, AND CONTAMINATION IN A FAST FOOD SERVICE RESTAURANT.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/09//
VL - 61
IS - 9
M3 - Article
SP - 1869
EP - 1885
PB - American Public Health Association
SN - 00900036
AB - A time-temperature survey of the thawing, cooking, hot holding, serving, chilling, and reheating processes, and a bacteriological survey of raw and cooked roasts and the kitchen environment of a fast food service roast beef sandwich operation, were made to determine the potential opportunities for contamination, survival, and incubation of Clostridium perfringens. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacillaceae
KW - Food industry
KW - Clostridium perfringens
KW - Clostridium
KW - Cooking (Beef)
KW - Hospitality industry
KW - Food service
KW - Restaurants
KW - Kitchens
N1 - Accession Number: 24845609; Bryan, Frank L. 1; Kilpatrick, Edward G. 2; Affiliations: 1: Foodborne Disease Activity, Health Agencies Branch, Training program, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Department of Health, Education and Welfare, Atlanta, GA; 2: Sanitation Section, Sanitary Engineering Division, North Carolina State Board of Health, Raleigh, NC; Issue Info: Sep1971, Vol. 61 Issue 9, p1869; Thesaurus Term: Bacillaceae; Thesaurus Term: Food industry; Subject Term: Clostridium perfringens; Subject Term: Clostridium; Subject Term: Cooking (Beef); Subject Term: Hospitality industry; Subject Term: Food service; Subject Term: Restaurants; Subject Term: Kitchens; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 722330 Mobile Food Services; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 722511 Full-Service Restaurants; NAICS/Industry Codes: 238299 All other building equipment contractors; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Jeffus, M. T.;
AU - Kenner, C. T.;
T1 - Protein interference in thiabendazole determination
CT - Protein interference in thiabendazole determination
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/09/01/
VL - 54
IS - Sep
SP - 1003
EP - 1005
AD - Food and Drug Administration, 3032 Bryan Street, Dallas, Texas 75204
N1 - Accession Number: 9-2872; Language: English; Chemical Name: Thiabendazole--148-79-8; Therapeutic Class: (8:08); AHFS Class: Anthelmintics thiabendazole; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Thiabendazole--analysis-;
KW - Anthelmintics--thiabendazole--analysis, interference, by proteins, in feeds;
KW - Feeds--thiabendazole--analysis, protein interference;
KW - Proteins--interference--thiabendazole, analysis, in feeds;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Champion, M. H.;
AU - Jones, J. H.;
T1 - Gas-liquid chromatographic identification and determination of alkanolamines. I. Application to aerosol hair sprays
CT - Gas-liquid chromatographic identification and determination of alkanolamines. I. Application to aerosol hair sprays
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/09/01/
VL - 54
IS - Sep
SP - 1175
EP - 1178
AD - Division of Colors and Cosmetics Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 10-4600; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Chromatography, gas--alkanolamines--aerosols, hair sprays;
KW - Aerosols--alkanolamines--chromatography, gas, hair sprays;
KW - Hair--sprays--alkanolamines, GLC;
KW - Alkanolamines--chromatography, gas--aerosols, hair sprays;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Fluorometric determination of estradiol valerate in sesame oil or ethyl oleate injectables
CT - Fluorometric determination of estradiol valerate in sesame oil or ethyl oleate injectables
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/09/01/
VL - 54
IS - Sep
SP - 1192
EP - 1194
AD - Food and Drug Administration, 1521 W. Pico Blvd., Los Angeles, California 90015
N1 - Accession Number: 9-2874; Language: English; Chemical Name: Estradiol--50-28-2; Therapeutic Class: (68:16); AHFS Class: Estrogens estradiol; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A fluorometric procedure was developed for the quantitative determination of estradiol valerate in sesame oil or ethyl oleate. An n-heptane solution of the steroid is purified, using a nitromethane partition column. The purified estradiol valerate is dissolved in alcohol and determined fluorometrically. The method is applicable to a variety of commercial preparations, including estradiol valerate-testosterone enanthate combinations. A total of 14 determinations on 5 different synthetic preparations gave an average recovery of 97.2%.
KW - Estradiol--valerate-;
KW - Fluorometry--estradiol--valerate, in sesame oil or ethyl oleate injections;
KW - Injections--estradiol--valerate, fluorometry, in sesame oil or ethyl oleate;
KW - Estrogens--estradiol--valerate, fluorometry, in sesame oil or ethyl oleate injections;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Banes, D.;
AU - Riggleman, O. H.;
T1 - Hybrid assay for trisulfapyrimidine preparations
CT - Hybrid assay for trisulfapyrimidine preparations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/09/01/
VL - 54
IS - Sep
SP - 1195
EP - 1199
AD - Office of Pharmaceutical Research and Testing, Bureau of Drugs, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 9-3271; Language: English; Chemical Name: Sulfadiazine--68-35-9 Sulfamerazine--127-79-7 Sulfamethazine--57-68-1; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method is described for the assay of trisulfapyrimidine tablets and trisulfapyrimidine oral suspension. Total sulfonamides are measured colorimetrically by the Bratton-Marshall procedure, and sulfadiazine is quantitated directly by means of its specific reaction with thiobarbituric acid. Sulfamethazine is separated from its homologs by column partition chromatography and is determined by UV spectrophotometry. When applied to commercial samples of trisulfapyrimidine tablets and oral suspensions, this hybrid method yields data that are consistent with assays of the same samples by the official nitrite titration method.
KW - Sulfadiazine--combination, sulfamerazine, sulfamethazine-;
KW - Sulfamerazine--combination, sulfadiazine, sulfamethazine-;
KW - Sulfamethazine--combination, sulfadiazine, sulfamerazine-;
KW - Sulfonamides--triple--analysis, dosage forms;
KW - Analysis--sulfonamides--triple, dosage forms;
KW - Dosage forms--sulfonamides--triple, analysis;
KW - Suspensions--sulfonamides--triple, analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Prosky, L.;
AU - O'Dell, R. G.;
T1 - In vivo converson of \SU/14\BS/C-labeled cyclamate to cyclohexylamine
CT - In vivo converson of \SU/14\BS/C-labeled cyclamate to cyclohexylamine
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/09/01/
VL - 60
IS - Sep
SP - 1341
EP - 1343
SN - 00223549
AD - Division of Nutrition, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 10-0146; Language: English; References: 22; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: D. R. Tousignaut
N2 - To determine the effects of long-term, low-level feeding of cyclamate on cyclamate metabolism, 2 groups of weanling rats were fed a chow diet and a chow diet containing 0.1% calcium cyclamate, respectively, for 8 months. Twelve rats from each group were then intubated with \SU/14\BS/C cyclamate; urine was collected for analysis by a paper electrophoretic method which separates cyclamate, cyclohexylamine, dicyclohexylamine, and N-hydroxycyclohexylamine. Elution of the radioactive areas from the paper indicated that none of the controls converted \SU/14\BS/C-cyclamate to additional products, but 7 of 11 cyclamate-fed rats converted cyclamate to cyclohexylamine. Isolated liver perfusion studies indicated that the liver is probably not the site of conversion.
KW - Cyclamates--calcium--labeled, C-14, conversion to cyclohexylamine, in rats;
KW - Metabolism--cyclamates--calcium, C-14 labeled, conversion to cyclohexylamine, in rats;
KW - Sweetening agents--cyclamates--calcium, C-14 labeled, conversion to cyclohexylamine, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wojtowicz, P. F.;
AU - Diliberto, J. J.;
T1 - Separation and quantitative assay of furazolidone and nifuroxime in suppositories by magnesium silicate adsorption column chromatography
CT - Separation and quantitative assay of furazolidone and nifuroxime in suppositories by magnesium silicate adsorption column chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/09/01/
VL - 60
IS - Sep
SP - 1385
EP - 1386
SN - 00223549
AD - Food and Drug Administration, Buffalo, New York 14202
N1 - Accession Number: 10-0391; Language: English; Chemical Name: Furazolidone--67-45-8 Nifuroxime--6236-05-1; Therapeutic Class: (8:32); AHFS Class: Trichomonacides nifuroxime, combination, furazolidone; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Furazolidone--combination, nifuroxime-;
KW - Nifuroxime--combination, furazolidone-;
KW - Chromatography--column--adsorption, suppositories, furazolidone, combination, nifuroxime;
KW - Trichomonacides--combination, nifuroxime--suppositories, adsorption column chromatography;
KW - Trichomonacides--nifuroxime, combination, furazolidone--chromatography, column, adsorption, suppositories;
KW - Suppositories--furazolidone, combination, nifuroxime--chromatography, column, adsorption;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schaplowsky, A. F.;
T1 - Medical aspects of childhood lead poisoning
CT - Medical aspects of childhood lead poisoning
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1971/09/01/
VL - 48
IS - Sep
SP - 464
EP - 468
SN - 00314005
AD - U. S. Public Health Service, Bureau of Community Environmental Management, Cincinnati, Ohio 45202
N1 - Accession Number: 9-1541; Language: English; Chemical Name: Lead--7439-92-1; References: 16; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Methodology; Abstract Author: Brenda Sue Martinez
N2 - Criteria for the diagnosis of lead poisoning in children were discussed. In screening programs, testing of 1-3 year olds should be given priority because this age group comprises 85% of the reported cases of plumbism and has the highest mortality rate from this poisoning. Ideally, screening programs for lead poisoning should include all children 1 to 6 years of age who are living in old, poorly maintained houses or otherwise exposed to lead. Since 90% or more of the measured lead in blood is attached to the red blood cells, low blood lead levels in anemic children may be misleading. A blood lead concentration of 40 mcg. or more per 100 ml. whole blood determined by the dithizone technique should be considered evidence of undue absorption of lead. Blood lead levels of 80 mcg. or more per 100 ml. whole blood should be considered unequivocal cases of lead poisoning and such children hospitalized immediately for chelation therapy.
KW - Lead--poisoning-;
KW - Pediatrics--lead--poisoning, criteria for diagnosis, in children;
KW - Poisoning--lead--pediatrics, criteria for diagnosis;
KW - Blood levels--lead--pediatrics, as criteria for diagnosis;
KW - Metabolism--lead--blood levels, as criteria for diagnosis, in children;
KW - Absorption--lead--and blood levels, criteria for diagnosis of poisoning, in children;
KW - Methodology--poisoning--lead, criteria for diagnosis, pediatrics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1972-11141-001
AN - 1972-11141-001
AU - Eisinger, Richard A.
T1 - Nicotine and addiction to cigarettes.
JF - British Journal of Addiction
JO - British Journal of Addiction
JA - Br J Addict
Y1 - 1971/09//
VL - 66
IS - 2
SP - 150
EP - 156
CY - United Kingdom
PB - Blackwell Publishing
SN - 0952-0481
N1 - Accession Number: 1972-11141-001. Other Journal Title: Addiction. Partial author list: First Author & Affiliation: Eisinger, Richard A.; United States Public Health Service, National Clearinghouse for Smoking & Health, Rockville, Md. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19720601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Drugs; Tobacco Smoking. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 7. Issue Publication Date: Sep, 1971.
AB - There appears to be some relationship, although it is not the most prominent dosage factor, between nicotine and psychological addiction to cigarettes. Investigations of physiological or pharmacological addiction to cigarettes have concentrated upon the primary importance of nicotine in the addictive process. Results of the analyses performed here would therefore suggest the independence of psychological addiction to cigarettes from the unvalidated concept of physiological or pharmacological addiction. (18 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nicotine & psychological addiction to cigarettes
KW - 1971
KW - Drug Addiction
KW - Drugs
KW - Tobacco Smoking
KW - 1971
DO - 10.1111/j.1360-0443.1971.tb02378.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1972-05433-001
AN - 1972-05433-001
AU - Fedio, Paul
AU - Buchsbaum, Monte
T1 - Unilateral temporal lobectomy and changes in evoked responses during recognition of verbal and nonverbal material in the left and right visual fields.
JF - Neuropsychologia
JO - Neuropsychologia
JA - Neuropsychologia
Y1 - 1971/09//
VL - 9
IS - 3
SP - 261
EP - 271
CY - Netherlands
PB - Elsevier Science
SN - 0028-3932
N1 - Accession Number: 1972-05433-001. PMID: 5149297 Partial author list: First Author & Affiliation: Fedio, Paul; National Inst. of Mental Health & Public Health Service, Surgical Neurology Branch, Bethesda, Md. Release Date: 19720301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evoked Potentials; Recognition (Learning); Surgery; Verbal Communication. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 11. Issue Publication Date: Sep, 1971.
AB - Tachistoscopically presented verbal and nonverbal stimuli for recognition to the left or right visual fields of 16 normal ss and 11 patients with unilateral temporal lobe removals. Direct hemiretinal projection to each occipital lobe (left hemiretina-left occiput, right hemiretina-right occiput) produced more stable evoked response waveforms than activation via the secondary visual afferent system. The most striking differences in cortical potentials evoked by the 2 classes of stimuli were associated with transmission of information from the right visual field (left hemiretina) to the left, presumed dominant speech hemisphere. Left temporal lobectomy ss displayed less stable evoked activity during presentation of verbal material while right temporal lobectomy ss had less stable potentials during presentation of nonverbal stimuli. The right temporal group also exhibited poorer averaged eeg responses from both hemispheres during discrimination of verbal and nonverbal stimuli, suggesting a more pervasive perceptual impairment. (french & german summaries) (35 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evoked responses during verbal & nonverbal recognition in left vs. right visual field
KW - unilateral temporal lobe removal patients
KW - 1971
KW - Evoked Potentials
KW - Recognition (Learning)
KW - Surgery
KW - Verbal Communication
KW - 1971
DO - 10.1016/0028-3932(71)90021-2
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Faich, G. A.;
AU - Graebner, R. W.;
AU - Sato, S.;
T1 - Failure of guanidine therapy in botulism A
CT - Failure of guanidine therapy in botulism A
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/09/30/
VL - 285
IS - Sep 30
SP - 773
EP - 776
SN - 00284793
AD - reprints: Enteric Diseases Section, Center for Disease Control, Atlanta, Georgia 30333
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U. S. Department of Health Education, and Welfare and Department of Neurology, University Hospitals, Madison, Wisconsin
N1 - Accession Number: 9-0986; Language: English; Chemical Name: Guanidine--113-00-8; References: 16; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - No clinical benefit resulted from the use of guanidine in the therapy of 4 patients with Type A botulism. Dosages of 45 mg./kg. of body weight per day were administered to all patients. In 3 patients dosages were reduced, and in one patient therapy was stopped completely because of dose related side effects.
KW - Guanidine--botulism-;
KW - Antidotes--guanidine--botulism, type A, therapy, lack of effect, in patients;
KW - Botulism--guanidine--therapy, type A, lack of effect, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Spectinomycin for acute gonorrhea
CT - Spectinomycin for acute gonorrhea
JO - FDA Drug Bull.
JF - FDA Drug Bull.
Y1 - 1971/10/01/
VL - Page
IS - Oct
SP - 1
AD - Bureau of Drugs, BD-40, Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 9-0279; Language: English; Chemical Name: Spectinomycin--1695-77-8; Therapeutic Class: (8:12); AHFS Class: Antibiotics spectinomycin; Journal Coden: FDADAJ; Section Heading: Legislation, Laws and Regulations; Drug Evaluations
N2 - The Food and Drug Administration has recently approved spectinomycin for marketing. The drug is indicated only in the treatment of acute gonorrheal urethritis, proctitis, and cervicitis, when due to susceptible strains of \IT/Neisseria gonorrhoeae\OK/.
KW - Spectinomycin--gonorrhea-;
KW - Antibiotics--spectinomycin--gonorrhea, therapy, FDA approval for marketing;
KW - Food and Drug Administration (U.S.)--spectinomycin--gonorrhea, therapy, approval for marketing;
KW - Drugs--clinical effectiveness--spectinomycin, gonorrhea, therapy, FDA approval for marketing;
KW - Regulations--spectinomycin--gonorrhea, therapy, FDA approval for marketing;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Methotrexate: its use in psoriasis
CT - Methotrexate: its use in psoriasis
JO - FDA Drug Bull.
JF - FDA Drug Bull.
Y1 - 1971/10/01/
VL - Page 1
IS - Oct
AD - Bureau of Drugs, BD-40, Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 9-0280; Language: English; Chemical Name: Methotrexate--59-05-2; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents methotrexate; Journal Coden: FDADAJ; Section Heading: Legislation, Laws and Regulations; Drug Evaluations
N2 - The Food and Drug Administration and the FDA's Advisory Committee on Dermatology have reviewed a series of clinical investigations and, based on the recommendations of the Advisory Committee, the FDA has concluded that methotrexate is safe and effective for the treatment of certain cases of psoriasis. Methotrexate should be used only when other, less toxic drugs have failed to bring improvement to patients disabled with severe psoriasis. Methotrexate is to be dispensed to patients by physicians only.
KW - Methotrexate--psoriasis-;
KW - Antineoplastic agents--methotrexate--psoriasis, therapy, FDA approval of use;
KW - Food and Drug Administration (U.S.)--methotrexate--psoriasis, therapy, approval of use;
KW - Dispensing--methotrexate--by physicians only, FDA approval;
KW - Psoriasis--methotrexate--therapy, FDA approval of use;
KW - Regulations--methotrexate--psoriasis, therapy, FDA approval of use;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Dumas, Neil S.
AU - Muthard, John E.
T1 - JOB ANALYSIS METHOD FOR HEALTH-RELATED PROFESSIONS: A PILOT STUDY OF PHYSICAL THERAPISTS.
JO - Journal of Applied Psychology
JF - Journal of Applied Psychology
Y1 - 1971/10//
VL - 55
IS - 5
M3 - Article
SP - 458
EP - 465
SN - 00219010
AB - A method for analyzing work of health personnel was devised and applied in a physical therapy service. Procedures for developing the special language for describing the tasks performed by physical therapists and methods for training observers to prepare sequential reports of the ongoing work of staff are presented. Observers were able to reliably report the detailed characteristics of the tasks in a physical therapy service over an extended period of time. Implications of the method are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB analysis
KW - JOB evaluation
KW - JOB descriptions
KW - TRAINING
KW - MEDICAL personnel
KW - PHYSICAL therapists
KW - OBSERVABILITY (Control theory)
N1 - Accession Number: 12361374; Dumas, Neil S. 1; Muthard, John E. 2; Affiliations: 1: National Center for Health Services Research and Development, United States Public health Service.; 2: Regional Rehabilitation Research Institute, University of Florida.; Issue Info: Oct71, Vol. 55 Issue 5, p458; Thesaurus Term: JOB analysis; Thesaurus Term: JOB evaluation; Thesaurus Term: JOB descriptions; Thesaurus Term: TRAINING; Thesaurus Term: MEDICAL personnel; Subject Term: PHYSICAL therapists; Subject Term: OBSERVABILITY (Control theory); NAICS/Industry Codes: 621340 Offices of Physical, Occupational and Speech Therapists, and Audiologists; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Gardner, E. A.;
T1 - Psychoactive drug utilization
CT - Psychoactive drug utilization
JO - Journal of Drug Issues (USA)
JF - Journal of Drug Issues (USA)
Y1 - 1971/10/01/
VL - 1
IS - Oct
SP - 295
EP - 300
SN - 00220426
AD - Bureau of Drugs, Food and Drug Administration, Department of Health, Education and Welfare, Washington, D.C.
N1 - Accession Number: 9-4295; Language: English; Journal Coden: JDGIA6; Section Heading: Sociology, Economics and Ethics; Abstract Author: Douglas L. Thompson
N2 - The increasing use of psychotherapeutic agents and the need to define legitimate indications for their use is discussed.
KW - Psychotherapeutic agents--use--increasing, and need to define legitimate indications;
KW - Rational therapy--psychotherapeutic agents--need, to define legitimate indications;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Woodson, A. L.;
T1 - 2,4-Dinitrophenylhydrazine: a sensitive quantitative reagent for determining microgram quantities of prednisone
CT - 2,4-Dinitrophenylhydrazine: a sensitive quantitative reagent for determining microgram quantities of prednisone
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/10/01/
VL - 60
IS - Oct
SP - 1538
EP - 1542
SN - 00223549
AD - Food and Drug Administration, Chicago, Illinois 60607
N1 - Accession Number: 10-1362; Language: English; Chemical Name: 2,4-Dinitrophenylhydrazine--119-26-6 Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone (28:08); AHFS Class: Analgesics and antipyretics prednisone; References: 14; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - 2,4-Dinitrophenylhydrazine is suggested as a quantitative colorimetric reagent for the determination of microgram quantities of prednisone. Extraction procedures are presented which isolate prednisone from formulations containing salicylamide, acetaminophen, aspirin, and ascorbic acid, where the ratio of analgesic to steroid is 300 to 1. 2,4-Dinitrophenylhydrazine quantitatively determines prednisone in concentrations as low as 1.26X10\SU/\-/6\BS/ M. Tables and graphs are included.
KW - 2,4-Dinitrophenylhydrazine--colorimetry-;
KW - Prednisone--colorimetry-;
KW - Colorimetry--prednisone--using 2,4-dinitrophenylhydrazine;
KW - Steroids, cortico---prednisone--colorimetry, using 2,4-dinitrophenylhydrazine;
KW - Analgesics and antipyretics--prednisone--colorimetry, in analgesic mixtures;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
AU - Tanner, J. T.;
AU - Lambert, J. P. F.;
T1 - Neutron activation analysis of halogens in drugs
CT - Neutron activation analysis of halogens in drugs
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/10/01/
VL - 60
IS - Oct
SP - 1550
EP - 1555
SN - 00223549
AD - National Center for Antibiotics Analysis and Division of Food Chemistry and Technology, Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 10-1148; Language: English; Chemical Name: Chlorine--7782-50-5 Bromine--7726-95-6 Iodine--7553-56-2; References: 8; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - A rapid, efficient, and highly specific method is presented for the determination of total chlorine, bromine, or iodine in various drugs. The halogen content is determined by nondestructive neutron activation and may be used for the presumptive assay of halogen-containing drugs in various dosage forms. \g/-Ray spectra are illustrated and numerous tables listing determinations are included.
KW - Chlorine--neutron activation analysis-;
KW - Bromine--neutron activation analysis-;
KW - Iodine--neutron activation analysis-;
KW - Neutron activation analysis--halogens--in dosage forms;
KW - Dosage forms--neutron activation analysis--of halogens;
KW - Halogens--neutron activation analysis--in dosage forms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Castor, G. B.;
AU - Kantor, N.;
AU - Knoll, E.;
AU - Blakely, J.;
AU - Nielsen, J. K.;
AU - \ET/;
T1 - Characteristics of a highly purified pyrogenic lipopolysaccharide
CT - Characteristics of a highly purified pyrogenic lipopolysaccharide
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/10/01/
VL - 60
IS - Oct
SP - 1578
EP - 1580
SN - 00223549
AD - National Center for Antibiotics Analysis, Bureau of Drugs, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0647; Language: English; References: 6; Publication Type: Notes; Journal Coden: JPMSAE; Section Heading: Preliminary Drug Testing; Pharmaceutical TechnologyMicrobiology
N2 - A highly purified lipopolysaccharide from Klebsiella pneumoniae was examined for qualitative chemical composition and, in a collaborative study, for pyrogenic activity. The principal constituents determined after hydrolysis were galactose and mannose, together with unidentified fatty acids. A dose of 0.001 mcg./kg. administered to groups of 8 rabbits resulted in a high percentage of positive pyrogenic responses as defined by U.S.P. XVIII.
KW - Pyrogens--lipopolysaccharides--from Klebsiella pneumoniae, characteristics;
KW - Lipopolysaccharides--pyrogens--from K. pneumoniae, characteristics;
KW - Klebsiella pneumoniae--pyrogens--lipopolysaccharides, characteristics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Challop, R. S.;
T1 - Role for cadmium in lead poisoning
CT - Role for cadmium in lead poisoning
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1971/10/21/
VL - 285
IS - Oct 21
SP - 970
EP - 971
SN - 00284793
AD - Bureau of Community Environmental Management, U. S. Public Health Service, Cincinnati, Ohio
N1 - Accession Number: 9-1598; Language: English; Chemical Name: Cadmium--7440-43-9 Lead--7439-92-1; References: 2; Publication Type: Letters; Journal Coden: NEJMAG; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - The implication of cadmium as a synergistic agent of symptomatic lead poisoning is being explored, since cadmium has been found in trace or even contaminant amounts in old paint. Reasons for the implication, concerning the poisoning of children by lead-based paints, are given.
KW - Cadmium--and lead-;
KW - Lead--and cadmium-;
KW - Drug interactions--cadmium and lead--synergism, possible, lead poisoning, in children;
KW - Paints--poisoning--pediatrics, possible synergism between cadmium and lead;
KW - Poisoning--lead--paints, in children, possible synergism of cadmium and lead;
KW - Toxicity--lead--paints, poisoning, in children, possible synergism of cadmium and lead;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lutz, Anne M.
AU - Stewart, Harold
T1 - TRENDS IN LASER APPLICATIONS: PUBLIC HEALTH IMPLICATIONS.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/11//
VL - 61
IS - 11
M3 - Article
SP - 2277
EP - 2281
PB - American Public Health Association
SN - 00900036
AB - The history of the laser industry is outlined. From early stages of laser applications research, financed almost wholly by the military, the growth of the industry is traced to its present international, multi-faceted status. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Laser industry -- Environmental aspects
KW - Lasers -- Industrial applications
KW - Military applications of lasers
KW - Optoelectronic devices
KW - Military supplies
KW - Laser weapons
KW - Laser materials
KW - Electronic apparatus & appliances
KW - Quantum electronics
N1 - Accession Number: 24851723; Lutz, Anne M. 1; Stewart, Harold 2; Affiliations: 1: Information Specialist, Southwestern Radiological Health Laboratory, P.O. Box 15027, Las Vegas, Nev. 89114; 2: Radiation Medicine Program, Southwestern Radiological Health Laboratory, U. S. Department of Health, Education, and Welfare, Public Health Service, Environmental Control Administration, Bureau of Radiological Health; Issue Info: Nov1971, Vol. 61 Issue 11, p2277; Subject Term: Laser industry -- Environmental aspects; Subject Term: Lasers -- Industrial applications; Subject Term: Military applications of lasers; Subject Term: Optoelectronic devices; Subject Term: Military supplies; Subject Term: Laser weapons; Subject Term: Laser materials; Subject Term: Electronic apparatus & appliances; Subject Term: Quantum electronics; NAICS/Industry Codes: 811211 Consumer Electronics Repair and Maintenance; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; NAICS/Industry Codes: 334413 Semiconductor and Related Device Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY -
AU - Yolles, Stanley F.1
T1 - Student Use of Drugs: Facts and Fables.
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1971/11//
Y1 - 1971/11//
VL - 37
IS - 3
CP - 3
M3 - Article
SP - 13
EP - 16
SN - 0013127X
AB - Focuses on issues related to drug abuse by students in the U.S. Despair of chronic poverty as a factor contributing to drug abuse by students; Number of non-narcotic drug abusers in the country; Concern generated by the use of marijuana.
KW - Students -- United States
KW - Drug abuse
KW - Poverty
KW - Marijuana
KW - Substance abuse
KW - United States
N1 - Accession Number: 18708676; Authors: Yolles, Stanley F. 1; Affiliations: 1: Assistant Surgeon General, U.S. Public Health Service.; Subject: Students -- United States; Subject: Drug abuse; Subject: Poverty; Subject: Marijuana; Subject: Substance abuse; Subject: United States; Number of Pages: 4p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Wegesa, P.
AU - Sulzer, A.J.
AU - Van Orden, Avis
T1 - A Slide Antigen in the Indirect Fluorescent Antibody Test for Trichinella spiralis .
JO - Immunology
JF - Immunology
Y1 - 1971/11//
VL - 21
IS - 5
M3 - Article
SP - 805
EP - 808
SN - 00192805
AB - A stable cuticular slide antigen was prepared for use in the indirect fluorescent antibody (IFA) test for trichinosis. Cuticles of Trichinella spiralis larvae, prepared by pepsin digestion, were embedded in Tissue-Tek OCT embedding medium, frozen, and sections made and mounted on slides. After storage at -70° for 2 days to allow the antigen sections to become firmly affixed to the slides, they may be used to perform the IFA test for trichinosis. This method is less timeconsuming, due to the elimination of centrifugation steps, than the antigen presently in use for the trichinosis IFA test, and should be applicable to other IFA procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - FLUORESCENT antibody technique
KW - IMMUNOGLOBULINS
KW - TRICHINELLA spiralis
KW - PEPSIN
KW - LARVAE
N1 - Accession Number: 14050297; Wegesa, P. 1; Sulzer, A.J. 2; Van Orden, Avis 2; Source Information: Nov71, Vol. 21 Issue 5, p805; Subject: ANTIGENS; Subject: FLUORESCENT antibody technique; Subject: IMMUNOGLOBULINS; Subject: TRICHINELLA spiralis; Subject: PEPSIN; Subject: LARVAE; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Hoskins, E. C.;
T1 - Determination of 1,4-dihydroxyanthraquinone in D&C Green No. 5 and the former External D&C Violet No. 2
CT - Determination of 1,4-dihydroxyanthraquinone in D&C Green No. 5 and the former External D&C Violet No. 2
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/11/01/
VL - 54
IS - Nov
SP - 1270
EP - 1271
AD - Division of Colors and Cosmetics, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0690; Language: English; Chemical Name: D&C Green No. 5--4405-90-1; Publication Type: Color Additives; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - D&C Green No. 5--contamination-;
KW - D&C Violet No. 2--External-;
KW - 1,4-Dihydroxyanthraquinone--contamination-;
KW - Dyes--D&C Green No. 5--contamination, 1,4-dihydroxyanthraquinone, determination;
KW - Dyes--D&C Violet No. 2--External, contamination, 1,4-dihydroxyanthraquinone, determination;
KW - Contamination--dyes--determination of 1,4-dihydroxyanthraquinone in D&C Green No. 5 and External D&C Violet No. 2;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Huang, A.;
AU - Firestone, D.;
T1 - Comparison of two infrared methods for the determination of isolated trans unsaturation in fats, oils, and methyl ester derivatives
CT - Comparison of two infrared methods for the determination of isolated trans unsaturation in fats, oils, and methyl ester derivatives
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/11/01/
VL - 54
IS - Nov
SP - 1288
EP - 1292
AD - Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0389; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Fats--spectrometry, infrared--determination of isolated trans unsaturation;
KW - Oils--spectrometry, infrared--determination of isolated trans unsaturation;
KW - Spectrometry, infrared--oils--and fats and methyl ester derivatives, determination of isolated trans unsaturation;
KW - Stability--fats--determination of isolated trans unsaturation by IR spectrometry;
KW - Stability--oils--determination of isolated trans unsaturation by IR spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Alber, L. L.;
AU - Overton, M. W.;
T1 - Individual tablet assay program for a small computer
CT - Individual tablet assay program for a small computer
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1971/11/01/
VL - 54
IS - Nov
SP - 1449
EP - 1452
AD - Food and Drug Administration, 433 West Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 9-2928; Language: English; References: 6; Journal Coden: JANCA2; Section Heading: Information Processing and Literature
N2 - A computer program is presented to rapidly calculate individual tablet analyses, using FOCAL-8 language in an off-line application of a small laboratory computer. The program, flow chart, and 2 examples of typical reports are included.
KW - Analysis--tablets--individual assay, program for small computer;
KW - Automation, data processing--computers--programs, individual tablet assay;
KW - Tablets--analysis--individual assay, program for small computer;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Arret, B.;
AU - Johnson, D. P.;
AU - Kirshbaum, A.;
T1 - Outline of details for microbiological assays of antibiotics: second revision
CT - Outline of details for microbiological assays of antibiotics: second revision
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1971/11/01/
VL - 60
IS - Nov
SP - 1689
EP - 1694
SN - 00223549
AD - National Center for Antibiotic Analysis, Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 10-2072; Language: English; References: 6; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Microbiology; Abstract Author: D. R. Tousignaut
N2 - Pertinent data are presented for the performance of 83 different microbiological assays for antibiotics. These include the official methods for all antibiotics approved for human use in the United States plus methods for 10 other antibiotics. Extensive tables listing test organisms for various assays, media, plate diffusion assays, and turbidimetric assays are included.
KW - Antibiotics--analysis--microbiological, survey of methods;
KW - Analysis--antibiotics--microbiological, survey of methods;
KW - Guidelines--antibiotics--analysis, microbiological, methods surveyed;
KW - Methodology--antibiotics--analysis, microbiological, methods surveyed;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ALLEVA, JOHN J.
AU - ALLEVA, FREDERIC R.
AU - FRY JR., BERT E.
AU - EANES, EDWARD D.
T1 - Calcium Carbonate Concretions: Cyclic Occurrence in the Hamster Vagina.
JO - Science
JF - Science
Y1 - 1971/11/05/
VL - 174
IS - 4009
M3 - Article
SP - 600
EP - 603
SN - 00368075
AB - Three crystalline forms of calcium carbonate were identified in washings of the hamster vagina. Spherical concretions of vaterite and hexagonal concretions of calcite predominate on days 3 and 4 of the 4-day estrous cycle. Dumbbell-like concretions of aragonite predominate during pregnancy and pseudopregnancy. Each polymorph is associated with an acid-insoluble matrix. Concretions disappear after ovariectomy and reappear during daily injections of estrogen and progesterone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002637; ALLEVA, JOHN J. 1; ALLEVA, FREDERIC R. 1; FRY JR., BERT E. 1; EANES, EDWARD D. 2; Affiliations: 1: Food and Drug Administration, Departmenit of Health, Education, and Welfare, Washington, D.C. 20204; 2: National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 11/ 5/1971, Vol. 174 Issue 4009, p600; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stokinger, H. E.
T1 - Sanity in Research and Evaluation of Environmental Health.
JO - Science
JF - Science
Y1 - 1971/11/12/
VL - 174
IS - 4010
M3 - Article
SP - 662
EP - 665
SN - 00368075
N1 - Accession Number: 88002655; Stokinger, H. E. 1,2,3; Affiliations: 1: Chairman, Threshold Limits Committee, American Conference of Governmental Industrial Hygienists; 2: Chairman, Subcommittee on Toxicology, Public Health Service Drinking Water Standards; 3: Chairman, National Research Council's Committee on Toxicology; Issue Info: 11/12/1971, Vol. 174 Issue 4010, p662; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morrill, E. Elbridge
AU - Oser, James L.
AU - Kusnetz, Howard L.
T1 - OCCUPATIONAL HEALTH INFORMATION SYSTEMS-- THEIR CONCEPTS AND FUNCTIONS.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1971/12//
VL - 61
IS - 12
M3 - Article
SP - 2469
EP - 2473
PB - American Public Health Association
SN - 00900036
AB - The efflorescence of many new chemicals and products has created the need for systems that will readily make information available. This is particularly important/or the occupational health specialist. Various systems are examined in this paper and the one best suited is discussed in detail. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Information resources
KW - Specialists
KW - Occupational health services
KW - Employee health promotion
KW - Medical personnel
KW - Occupational medicine
KW - United States
KW - Library of Congress
N1 - Accession Number: 24878178; Morrill, E. Elbridge 1; Oser, James L. 2; Kusnetz, Howard L. 3; Affiliations: 1: Sanitary Engineer, Region 3, U. S. Forest Service, Department of Agriculture, 517 Gold Ave., S.W., Albuquerque, New Mexico 87101; 2: Assistant Chief, Scientific Reference Service Branch, National Institute for Occupational Safety and Health, 1014 Broadway, Cincinnati, Ohio 45200; 3: Manager, Industrial Hygiene, Shell Oil Company, 1-Shell Plaza, Houston, Texas 77002.; Issue Info: Dec1971, Vol. 61 Issue 12, p2469; Thesaurus Term: Industrial hygiene; Subject Term: Information resources; Subject Term: Specialists; Subject Term: Occupational health services; Subject Term: Employee health promotion; Subject Term: Medical personnel; Subject Term: Occupational medicine; Subject: United States ; Company/Entity: Library of Congress; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hayes, T. A.;
T1 - Bioavailability: an FDA view
CT - Bioavailability: an FDA view
JO - Drug Cosmet. Ind.
JF - Drug Cosmet. Ind.
Y1 - 1971/12/01/
VL - 109
IS - Dec
SP - 44
EP - 38
AD - Division of Extramural and Clinical Research, Office of Scientific Coordination, Food and Drug Administration, FDA Bureau of Drugs, Rockville, Maryland
N1 - Accession Number: 9-2524; Language: English; Journal Coden: DCINAQ; Section Heading: Legislation, Laws and Regulations; Abstract Author: Douglas L. Thompson
N2 - Events which led the Food and Drug Administration into the role of making requirements for bioavailability and approving new drugs based on this evidence are discussed. It is stated that the Bureau of Drugs is interested in data on bioavailability because there are no other ways to assure that chemically equivalent preparations will perform similarly in human use.
KW - Food and Drug Administration (U.S.)--regulations--availability, drugs, viewpoint;
KW - Drugs--availability--viewpoint, FDA;
KW - Regulations--availability--drugs, FDA viewpoint;
KW - Drugs--clinical effectiveness--need for availability data, FDA viewpoint;
KW - Equivalency--drugs--need for availability data, FDA viewpoint;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Wilson, P. David
AU - Tonascia, James
T1 - Tables for Shortest Confidence Intervals on the Standard Deviation and Variance Ratio from Normal Distributions.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1971/12//
VL - 66
IS - 336
M3 - Article
SP - 909
SN - 01621459
AB - Tables are presented for Bayes shortest posterior intervals on the standard deviation and variance ratio of normal distributions. A general procedure for obtaining such Interval, is reviewed, and a discussion of frequentist shortest intervals is given along with frequentist interpretations of the intervals from these tables. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BAYESIAN analysis
KW - GAUSSIAN distribution
KW - FUNCTIONAL analysis
KW - STANDARD deviations
KW - ANALYSIS of variance
KW - STATISTICS
KW - THEORY of distributions (Functional analysis)
KW - CONFIDENCE intervals
N1 - Accession Number: 4610372; Wilson, P. David 1; Tonascia, James 2; Affiliations: 1: Mathematical Statistician, Food and Drug Administration, U.S. Department of Health, Education and Welfare, Rockville, Md. 20852.; 2: Assistant Professor, Department of Biostatistics, The Johns Hopkins University, Baltimore, Md. 21205.; Issue Info: Dec71, Vol. 66 Issue 336, p909; Thesaurus Term: BAYESIAN analysis; Thesaurus Term: GAUSSIAN distribution; Thesaurus Term: FUNCTIONAL analysis; Thesaurus Term: STANDARD deviations; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: STATISTICS; Subject Term: THEORY of distributions (Functional analysis); Subject Term: CONFIDENCE intervals; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1972-10846-001
AN - 1972-10846-001
AU - Eisinger, Richard A.
T1 - Psychosocial predictors of smoking recidivism.
JF - Journal of Health and Social Behavior
JO - Journal of Health and Social Behavior
JA - J Health Soc Behav
Y1 - 1971/12//
VL - 12
IS - 4
SP - 355
EP - 362
CY - US
PB - American Sociological Assn
SN - 0022-1465
SN - 2150-6000
N1 - Accession Number: 1972-10846-001. PMID: 5130038 Other Journal Title: Journal of Health & Human Behavior. Partial author list: First Author & Affiliation: Eisinger, Richard A.; United States Public Health Service, Washington, D.c. Other Publishers: Sage Publications. Release Date: 19720601. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitudes; Demographic Characteristics; Environment; Tobacco Smoking. Classification: Social Processes & Social Issues (2900). Population: Human (10). Page Count: 8. Issue Publication Date: Dec, 1971.
AB - Reinterviewed 566 former cigarette smokers who had been interviewed in 1964. In the 2-yr interim 72 had returned to smoking cigarettes. Recidivism was examined as a function of selected demographic, environmental, behavioral, and attitudinal variables. Univariate and multivariate analyses of the data were performed. A stepwise multiple discriminant analysis revealed that a set of 3 variables was highly effective in predicting recidivism: (a) smoking status at the time of the surgeon general's report, (b) expectation of smoking 5 yr. Later, and (c) using expense as a reason for quitting. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking recidivism prediction
KW - demographic & environmental & behavioral & attitudinal variables
KW - former cigarette smokers
KW - 1971
KW - Attitudes
KW - Demographic Characteristics
KW - Environment
KW - Tobacco Smoking
KW - 1971
DO - 10.2307/2137080
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1972-20920-001
AN - 1972-20920-001
AU - Bergman, Robert L.
T1 - Navajo peyote use: Its apparent safety.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1971/12//
VL - 128
IS - 6
SP - 695
EP - 699
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1972-20920-001. PMID: 5147724 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Bergman, Robert L.; U.S. Public Health Service, Mental Health Programs, Window Rock, Ariz. Release Date: 19720701. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Usage; Drugs; Ego; Ethnology. Classification: Social Processes & Social Issues (2900). Population: Human (10). Page Count: 5. Issue Publication Date: Dec, 1971.
AB - Discusses the use of significant quantities of peyote, a hallucinogenic plant containing mescaline, in the religious ceremonies of Navajo Indians. Since there have been many reports of serious emotional disturbances caused by similar drugs, the rate of such illness in this population was investigated in a 4-yr experiment. It was found that the rate was very low, probably because (a) the feelings evoked by the drug experience are channeled by church belief and practice into ego-strengthening directions, and (b) there are built-in safeguards against bad reactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - peyote use
KW - channeling of drug experience by church belief & practice into ego-strengthening directions & safeguards against bad reactions
KW - Navajo Indians
KW - 1971
KW - Drug Usage
KW - Drugs
KW - Ego
KW - Ethnology
KW - 1971
DO - 10.1176/ajp.128.6.695
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hart, Jacob
AU - Shani, Mordechai
AU - Modan, Baruch
T1 - Epidemiological Aspects of Gallbladder and Biliary Tract Neoplasm.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/01//
VL - 62
IS - 1
M3 - Article
SP - 36
EP - 39
PB - American Public Health Association
SN - 00900036
AB - All newly diagnosed cases of gallbladder cancer in Israel over a six-year period were reviewed. Incidence findings are reported with respect to sex, and the distribution among females born in Europe, Asia, and Africa. The findings presented seem to suggest an etiological role for cholelithiasis in gallbladder cancer, but the authors emphasize the need for substantiation by prospective studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases -- Causes & theories of causation
KW - DISEASES
KW - Gallbladder -- Cancer
KW - Bilious diseases & biliousness
KW - Cancer -- Diagnosis
KW - Gallstones
KW - Females
KW - Europe
KW - Asia
KW - Africa
KW - Israel
N1 - Accession Number: 24293978; Hart, Jacob 1; Shani, Mordechai 1; Modan, Baruch 1; Affiliations: 1: Department of Clinical Epidemiology, Tel Hashomer Government Hospital, Tel Aviv, Israel. This study was supported by research agreement No. 06-125-2 from the U.S. Public Health Service. This paper was presented before the Epidemiology Section of the American Public Health Association at the Ninety-Eighth Annual Meeting in Houston, Tex., October 27, 1970; Issue Info: Jan1972, Vol. 62 Issue 1, p36; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: DISEASES; Subject Term: Gallbladder -- Cancer; Subject Term: Bilious diseases & biliousness; Subject Term: Cancer -- Diagnosis; Subject Term: Gallstones; Subject Term: Females; Subject: Europe; Subject: Asia; Subject: Africa; Subject: Israel; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dedrick, R. L.;
AU - Forrester, D. D.;
AU - Ho, D. H. W.;
T1 - In vitro-in vivo correlation of drug metabolism\M/deamination of 1-\b/-D-arabinofuranosylcytosine
CT - In vitro-in vivo correlation of drug metabolism\M/deamination of 1-\b/-D-arabinofuranosylcytosine
JO - Biochem. Pharmacol.
JF - Biochem. Pharmacol.
Y1 - 1972/01/01/
VL - 21
IS - Jan 1
SP - 1
EP - 6
AD - Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Insitutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 9-3713; Language: English; Trade Name: Ara-C--1-\b/-D-Arabinofuranosylcytosine; Generic Name: Cytarabine; Cytarabine; Chemical Name: Cytarabine--147-94-4; Therapeutic Class: (10:00); AHFS Class: Antineoplastic agents cytarabine; References: 21; Journal Coden: BCPCA6; Section Heading: Methodology
N2 - It is shown how enzyme kinetics in vitro can be used in conjunction with a mathematical model of the distribution and excretion of 1-\b/-D-arabinofuranosylcytosine (Ara-C; cytarabine) and 1-\b/-D-arabinofuranosyluracil (Ara-U) to predict plasma concentrations in man after a single I.V. dose of the parent compound. The model is based on physiologic and anatomic principles and is validated by comparison of predicted urinary excretion of cytarabine and its metabolite with published data from humans. Model predictions are compared with new data on plasma concentrations of the drug and its metabolite as functions of time after I.V. pulse doses of 1.2 and 86 mg./kg. of the parent compound.
KW - Cytarabine--blood levels-;
KW - 1-\b/-D-Arabinofuranosyluracil--blood levels-;
KW - Pharmacokinetics--models--for in vitro\M/in vivo correlation of drug metabolism, prediction of cytarabine and metabolite blood levels;
KW - Models--pharmacokinetics--in vitro\M/in vivo correlation of drug metabolism, prediction of blood levels of cytarabine and metabolite;
KW - Blood levels--cytarabine--prediction, including metabolite, use of pharmacokinetic model;
KW - Metabolism--cytarabine--deamination, prediction of blood levels, using pharmacokinetic model;
KW - Antineoplastic agents--cytarabine--and metabolite, blood levels, prediction, using pharmacokinetic model;
KW - Methodology--blood levels--cytarabine, prediction using pharmacokinetic model to correlate in vitro-in vivo data;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kantor, N.;
AU - Saunders, P.;
AU - Lamberti, A.;
AU - Bowman, F.;
T1 - Cellulase: its use in sterility testing
CT - Cellulase: its use in sterility testing
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1972/01/01/
VL - 26
IS - Jan-Feb
SP - 41
EP - 50
AD - National Center for Antibiotics Analysis, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 10-0201; Language: English; Chemical Name: Cellulase--9012-54-8 Carboxymethylcellulose--9000-11-7; Therapeutic Class: (44:00); AHFS Class: Enzymes cellulase; References: 6; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - The use of cellulase as a solubilizing enzyme in sterility testing of parenteral drugs containing carboxymethylcellulose (CMC) was investigated. Parenteral drugs containing CMC cannot be tested for sterility by means of the membrane filtration method in many instances because of the clogging effect of the suspending agent, but the CMC can be solubilized by the enzyme, cellulase. The question of how much cellulase is required was investigated with 7 enzyme systems by using 2 assay procedures for cellulolytic activity: change in viscosity and increase in reducing end groups. These methods were unsatisfactory for the stated purpose. A pragmatic filtration rate test was developed which has been very useful in the sterility testing of antibiotic dosage forms containing CMC. This ""performance'' test led to the selection of the best (from an economic view point) enzyme preparation presently available.
KW - Cellulase--enzymes-;
KW - Carboxymethylcellulose--injections-;
KW - Enzymes--cellulase--solubilizing, carboxymethylcellulose, sterility testing of injections;
KW - Injections--carboxymethylcellulose--sterility, testing, solubilization by cellulase;
KW - Sterility--tests--injections, carboxymethylcellulose, solubilization by cellulase;
KW - Tests--sterility--injections, containing carboxymethylcellulose, solubilization with cellulase;
KW - Solubilization--carboxymethylcellulose--constituents, injections, use of cellulase in sterility tests;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jasinski, D. R.;
AU - Mansky, P. A.;
T1 - Evaluation of nalbuphine for abuse potential
CT - Evaluation of nalbuphine for abuse potential
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1972/01/01/
VL - 13
IS - Jan-Feb
SP - 78
EP - 90
SN - 00099236
AD - N.I.M.H. Addiction Research Center, U.S. Department of HEW, Public Health Service, Health Services and Mental Health Administration, Lexington, Kentucky
N1 - Accession Number: 9-4494; Language: English; Chemical Name: Nalbuphine--20594-83-6; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics nalbuphine; References: 19; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: Drew Edwards
N2 - Nalbuphine is a narcotic antagonist and analgesic, which in a dose of 8 mg./70 kg. in man, produces subjective effects which resemble those of 10 mg./70 kg. of morphine. Nalbuphine, in doses of 24 and 72 mg./70 kg., produces mild effects which more closely resemble those of nalorphine. Nalbuphine is one-fourth as potent as nalorphine in precipitating abstinence in subjects dependent on 60 mg. of morphine per day. Chronic administration of nalbuphine produces physical dependence which resembles that produced by pentazocine, since it has elements of both morphine and nalorphine dependence. It is concluded that nalbuphine has an abuse potential which approximates that of pentazocine, but equianalgesic doses of nalbuphine produce less nalorphine-like effects than does pentazocine.
KW - Nalbuphine--dependence-;
KW - Analgesics and antipyretics--nalbuphine--dependence, evaluation, for abuse potential, in humans;
KW - Dependence--nalbuphine--potential, evaluation, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Paulus, G. L.;
T1 - Gas-liquid chromatographic characterization of sunscreens in suntan preparations
CT - Gas-liquid chromatographic characterization of sunscreens in suntan preparations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 47
EP - 50
AD - Division of Colors and Cosmetics Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0688; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Chromatography, gas--sunscreen agents--in suntan preparations;
KW - Sunscreen agents--chromatography, gas--in suntan preparations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Siegmund, E. G.;
T1 - Column partition chromatographic assay for codeine in tablets containing APC (aspirin, phenacetin, caffeine)
CT - Column partition chromatographic assay for codeine in tablets containing APC (aspirin, phenacetin, caffeine)
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 142
EP - 145
AD - Food and Drug Administration, 1521 W. Pico Boulevard, Los Angeles, California 90015
N1 - Accession Number: 10-0684; Language: English; Chemical Name: Codeine--6059-47-8; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics codeine; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Codeine--combination, aspirin, phenacetin, caffeine-;
KW - Chromatography--column--partition, codeine, in APC tablets;
KW - Analgesics and antipyretics--codeine--chromatography, column partition, in APC tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wells, C. E.;
T1 - Collaborative study of the gas-liquid chromatographic method for determination of stereochemical composition of amphetamine
CT - Collaborative study of the gas-liquid chromatographic method for determination of stereochemical composition of amphetamine
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 146
EP - 148
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 10-0681; Language: English; Chemical Name: Dextroamphetamine--51-64-9 Amphetamine--300-62-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A quantitative GLC method for d- and l-amphetamine in tablets is described. The drugs are separated from tablet excipients by column chromatography and reacted with N-trifluoroacetyl-(l)-prolyl chloride, and the resulting derivatives are analyzed by GLC. The samples consisted of commercial dextroamphetamine sulfate tablets (with and without butabarbital), dl-amphetamine sulfate tablets, and a mixed d- and l-amphetamine sulfate standard. Recoveries were acceptable, and the standard deviation never exceeded 0.64%.
KW - Dextroamphetamine--chromatography, gas-;
KW - Amphetamine--isomers-;
KW - Central nervous system stimulants--amphetamine--isomers, tablets, GLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Barkan, S.;
T1 - Collaborative study of the single tablet determination of reserpine
CT - Collaborative study of the single tablet determination of reserpine
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 149
EP - 151
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0682; Language: English; Chemical Name: Reserpine--50-55-5; Therapeutic Class: (24:08); AHFS Class: Hypotensive agents reserpine; References: 9; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A fluorometric single tablet determination of reserpine was subjected to collaborative study. Fourteen collaborators, divided into 2 groups, analyzed commercial 0.1 and 1 mg. tablets and single tablet weights of the respective composites prepared from the same tablets. The analyses were satisfactory and the collaborators reported that the method presented no difficulties.
KW - Reserpine--fluorometry-;
KW - Fluorometry--reserpine--tablets;
KW - Hypotensive agents--reserpine--fluorometry, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kaplan, G. B.;
AU - Levine, J.;
T1 - Column chromatographic assay for sodium butabarbital in tablets
CT - Column chromatographic assay for sodium butabarbital in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 152
EP - 154
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0683; Language: English; Chemical Name: Butabarbital--125-40-6; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics butabarbital; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A column partition chromatographic assay for sodium butabarbital tablets is described. The method was collaboratively studied with a composite of commercial tablets and a preparation of known composition as samples. The average recovery for both samples was 99.3%; the standard deviations were 1.4 and 1.1%, respectively.
KW - Butabarbital--sodium-;
KW - Sedatives and hypnotics--butabarbital--sodium, tablets, column chromatography;
KW - Chromatography--column--butabarbital, sodium, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Plank, W. M.;
T1 - Determination of bismuth in pharmaceutical dosage forms by conventional DC polarography
CT - Determination of bismuth in pharmaceutical dosage forms by conventional DC polarography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 155
EP - 160
AD - Food and Drug Administration, 850 Third Avenue, Brooklyn, N.Y. 11232
N1 - Accession Number: 10-0685; Language: English; Chemical Name: Bismuth--7440-69-9; Therapeutic Class: (56:08); AHFS Class: Antidiarrhea agents bismuth; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Bismuth--polarography-;
KW - Antidiarrhea agents--bismuth--polarography, dosage forms;
KW - Polarography--bismuth--dosage forms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazzari, F. R.;
T1 - Collaborative study of assay for benzthiazide and hydrochlorothiazide in pharmaceuticals
CT - Collaborative study of assay for benzthiazide and hydrochlorothiazide in pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 161
EP - 162
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0679; Language: English; Chemical Name: Benzthiazide--91-33-8 Hydrochlorothiazide--58-93-5; Therapeutic Class: (40:28); AHFS Class: Diuretics benzthiazide (40:28); AHFS Class: Diuretics hydrochlorothiazide; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A column partition chromotographic technique with an IR spectrophotometric determination is described for thiazide tablet dosage forms. The average percent recovered and standard deviation for preparations of benzthiazide and hydrochlorothiazide were, respectively, 99.51.35 and 99.61.22.
KW - Benzthiazide--chromatography-;
KW - Hydrochlorothiazide--chromatography-;
KW - Diuretics--benzthiazide--chromatography, column partition, and IR spectrometry, tablets;
KW - Diuretics--hydrochlorothiazide--chromatography, column partition, and IR spectrometry, tablets;
KW - Chromatography--column--partition, thiazides, and IR spectrometry, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gilvydis, D. M.;
T1 - Collaborative study of the determination of dichlorophene in veterinary preparations by ultraviolet spectrophotometry
CT - Collaborative study of the determination of dichlorophene in veterinary preparations by ultraviolet spectrophotometry
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 163
EP - 165
AD - Food and Drug Administration, 1560 E. Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 10-0680; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Dichlorophene--spectrometry, ultraviolet-;
KW - Spectrometry, ultraviolet--dichlorophene--dosage forms, veterinary;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lampkin, W. T.;
T1 - Gas-liquid chromatographic determination of paraldehyde in paraldehyde elixir
CT - Gas-liquid chromatographic determination of paraldehyde in paraldehyde elixir
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 166
EP - 169
AD - Food and Drug Administration, 1141 Central Parkway, Cincinnati, Ohio 45202
N1 - Accession Number: 10-0689; Language: English; Chemical Name: Paraldehyde--123-63-7; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics paraldehyde; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Paraldehyde--chromatography, gas-;
KW - Elixirs--paraldehyde--chromatography, gas;
KW - Chromatography, gas--paraldehyde--elixirs;
KW - Sedatives and hypnotics--paraldehyde--chromatography, gas;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cunningham, C. G.;
AU - Brunner, C. A.;
AU - Levine, J.;
T1 - Collaborative study of a column chromatographic method for sodium diphenylhydantoin in capsules
CT - Collaborative study of a column chromatographic method for sodium diphenylhydantoin in capsules
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 170
EP - 172
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0678; Language: English; Chemical Name: Diphenylhydantoin--57-41-0; Therapeutic Class: (28:12); AHFS Class: Anticonvulsants diphenylhydantoin; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Diphenylhydantoin--sodium-;
KW - Chromatography--column--diphenylhydantoin, sodium;
KW - Anticonvulsants--diphenylhydantoin--sodium, chromatography, column;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, E.;
AU - Sheinin, E. B.;
AU - Levine, J.;
T1 - Partition chromatographic-gravimetric assay of opium
CT - Partition chromatographic-gravimetric assay of opium
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 173
EP - 176
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-1358; Language: English; Chemical Name: Opium--8008-60-4 Morphine--57-27-2; Therapeutic Class: (28:08); AHFS Class: Analgesics and antipyretics morphine; References: 7; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A chromatographic separation of opium samples which provided large enough samples for the gravimetric separation of the dinitrophenyl ether of morphine is described. The gravimetric procedure yields values comparable to those obtained by the much shorter and simpler UV method.
KW - Opium--chromatography-;
KW - Morphine--chromatography-;
KW - Chromatography--column--partition, opium, and gravimetric analysis;
KW - Analgesics and antipyretics--morphine--chromatography, column, partition, and gravimetric analysis, opium samples;
KW - Gravimetry--morphine--in opium samples separated by partition column chromatography;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pfabe, Y. H.;
T1 - Collaborative study of a colorimetric determination of nitroglycerin in sublingual tablets
CT - Collaborative study of a colorimetric determination of nitroglycerin in sublingual tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 187
EP - 189
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 10-1356; Language: English; Chemical Name: Nitroglycerin--55-63-0; Therapeutic Class: (24:12); AHFS Class: Vasodilating agents nitroglycerin; References: 9; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Nitroglycerin is hydrolyzed to nitrite, which diazotizes p-chloroaniline; this diazotization product is coupled with N-(1-naphthyl)-ethylenediamine dihydrochloride and measured at 560 nm. Samples were analyzed at a composite level (1.2 mg.) and at an individual tablet level (0.15-0.6 mg.). Coefficients of variation ranged from 4 to 14%, with the highest variation in the individual assay of low dosage tablets. Samples analyzed 6 months after the first analysis showed lower assay results, indicating deterioration. It was recommended that the study be continued with a much shorter interval between preparation and analysis of samples.
KW - Nitroglycerin--colorimetry-;
KW - Colorimetry--nitroglycerin--tablets, sublingual;
KW - Vasodilating agents--nitroglycerin--colorimetry, sublingual tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, J. H.;
AU - Banes, D.;
AU - Proctor, J. B.;
T1 - Determination of dienestrol in pharmaceuticals
CT - Determination of dienestrol in pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 190
EP - 193
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-1357; Language: English; Chemical Name: Dienestrol--84-17-3; Therapeutic Class: (68:16); AHFS Class: Estrogens dienestrol; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Dienestrol is separated from excipient matter and other drugs present in the dosage form by column chromatography and determined spectrophotometrically as a substituted indene, formed by acid-induced isomerization of dienestrol. The procedure is directly applicable to creams and individual tablets.
KW - Dienestrol--chromatography-;
KW - Estrogens--dienestrol--chromatography, column, dosage forms, and spectrometry;
KW - Chromatography--column--dienestrol, and spectrometry;
KW - Spectrometry--dienestrol--following column chromatography;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brunner, C. A.;
T1 - Analysis of trisulfapyrimidine preparations by thin layer chromatography
CT - Analysis of trisulfapyrimidine preparations by thin layer chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 194
EP - 196
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0675; Language: English; Trade Name: Trisulfapyrimidines; Generic Name: Sulfonamides; Chemical Name: Sulfadiazine--68-35-9 Sulfamerazine--127-79-7 Sulfamethazine--57-68-1; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A TLC method for the analysis of tablets and suspensions containing sulfadiazine, sulfamerazine and sulfamethazine is described. The sulfonamides are resolved into compact, well separated bands which are collected and quantitatively extracted. Colorimetric analysis is carried out after diazotization and coupling with N-(1-naphthyl)ethylenediamine. The relative values of the 3 isolated compounds provide an index of their ratio in the sample. Separate assay of the unresolved mixture gives the total sulfonamide content of the sample.
KW - Sulfadiazine--combination, sulfamerazine, sulfamethazine-;
KW - Sulfamerazine--combination, sulfadiazine, sulfamethazine-;
KW - Sulfamethazine--combination, sulfamerazine, sulfadiazine-;
KW - Sulfonamides--triple--chromatography, thin layer and colorimetry;
KW - Chromatography, thin layer--sulfonamides--triple, and colorimetry;
KW - Colorimetry--sulfonamides--triple, following TLC separation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pla, G. W.;
AU - Fritz, J. C.;
T1 - Human plasma iron responses following test doses of iron from known sources
CT - Human plasma iron responses following test doses of iron from known sources
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/01/01/
VL - 55
IS - Jan
SP - 197
EP - 199
AD - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-0885; Language: English; Chemical Name: Iron--7439-89-6 Ferrous sulfate--7782-63-0 Ascorbic acid--50-81-7; References: 28; Journal Coden: JANCA2; Human Indicator: Yes; Section Heading: Drug Interactions
N2 - A study was conducted to determine the effects of certain dietary components on iron absorption in human subjects. Iron absorption was measured by plasma iron responses following test doses of iron as ferrous sulfate or ferric pyrophosphate alone or with egg, enriched white bread, or ascorbic acid. The effects of egg on iron absorption were inconclusive. Phytates at the level present in enriched white bread had no adverse effects and 500 mg. ascorbic acid proved beneficial.
KW - Iron--absorption-;
KW - Ferrous sulfate--blood levels-;
KW - Ferric pyrophosphate--blood levels-;
KW - Ascorbic acid--interactions-;
KW - Absorption--iron--blood levels, effects, dietary constituents, in humans;
KW - Blood levels--ferrous sulfate--effects, dietary constituents, in humans;
KW - Blood levels--ferric pyrophosphate--effects, dietary consitituents, in humans;
KW - Metabolism--ferrous sulfate--blood levels, effects, dietary constituents, in humans;
KW - Metabolism--ferric pyrophosphate--blood levels, effects, dietary constituents, in humans;
KW - Drug interactions--ferrous sulfate and ascorbic acid--increases iron absorption, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1973-26007-001
AN - 1973-26007-001
AU - Dean, E. Faith
T1 - A lengthened Mini: The Midi-Mult.
JF - Journal of Clinical Psychology
JO - Journal of Clinical Psychology
JA - J Clin Psychol
Y1 - 1972/01//
VL - 28
IS - 1
SP - 68
EP - 71
CY - US
PB - John Wiley & Sons
SN - 0021-9762
SN - 1097-4679
N1 - Accession Number: 1973-26007-001. PMID: 4400454 Other Journal Title: In Session: Psychotherapy in Practice. Partial author list: First Author & Affiliation: Dean, E. Faith; United States Public Health Service Hosp., Baltimore, Md. Release Date: 19731001. Correction Date: 20130624. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Minnesota Multiphasic Personality Inventory. Classification: Psychometrics & Statistics & Methodology (2200). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1972.
AB - In 1 sample, a Mini-Mult analysis was performed and resulted in 3 scales (L, F, Ma) indicating lower correlations. New item subsets were devised to serve as short forms for these scales. A 2nd sample of MMPI data was obtained and various combinations of items were utilized until revised short forms of L, F, and Ma correlated at least .80 with the long form. These changes resulted in an expansion of the Mini-Mult from 71 to 86 items. This 86-item lengthened version was titled Midi-Mult. A 3rd sample was collected using both the long- and short-form scales. The resulting short scales correlated .80 or higher with standard scales. The necessity of validating an abbreviated version of the MMPI on any population is suggested. The Mini-Mult should be used with psychiatric patients and the Midi-Mult with normals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Midi-Mult short form of MMPI
KW - 1972
KW - Minnesota Multiphasic Personality Inventory
KW - 1972
DO - 10.1002/1097-4679(197201)28:1<68::AID-JCLP2270280123>3.0.CO;2-N
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DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 1973-21425-000
AN - 1973-21425-000
AU - Brown, Daniel G.
T1 - Behavior modification in child, school, and family mental health: An annotated bibliography on applications with parents and teachers and in marriage and family counseling.
Y1 - 1972///
CY - Champaign, IL, US
PB - Research Press
N1 - Accession Number: 1973-21425-000. Partial author list: First Author & Affiliation: Brown, Daniel G.; Phoenix Area Indian Health Service, Ariz. Release Date: 19730701. Publication Type: Book (0200). Format Covered: Print. Language: English. Major Descriptor: Behavior Modification; Classroom Behavior Modification; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300); Educational Psychology (3500). Population: Human (10). Page Count: 105.
KW - annotated bibliography
KW - behavior modification
KW - child & school & family mental health
KW - book
KW - 1972
KW - Behavior Modification
KW - Classroom Behavior Modification
KW - Mental Health
KW - 1972
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Warmolts, J. R.;
AU - Engel, W. K.;
T1 - Benefit from alternate-day prednisone in myasthenia gravis
CT - Benefit from alternate-day prednisone in myasthenia gravis
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/01/06/
VL - 286
IS - Jan 6
SP - 17
EP - 20
SN - 00284793
AD - Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 9-1867; Language: English; Chemical Name: Prednisone--53-03-2; Therapeutic Class: (68:04); AHFS Class: Steroids, cortico- prednisone; References: 18; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Five adults with myasthenia gravis of varying severity and duration were treated with long-term, high single dosage (100 mg.), alternate-day oral prednisone. Improvement in muscle function appeared 24 to 72 hours after the initiation of therapy and has been maintained from 6 to 17 months. Complete remission of symptoms was obtained in one patient in 4 months and has been maintained for 13 months.
KW - Prednisone--myasthenia gravis-;
KW - Steroids, cortico---prednisone--myasthenia gravis, therapy, high dose, in patients;
KW - Dosage--prednisone--high, myasthenia gravis, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - THOMAS, PAUL J.
AU - FAVERO, MARTIN S.
T1 - Contamination of Distilled Water.
JO - Science
JF - Science
Y1 - 1972/01/07/
VL - 175
IS - 4017
M3 - Article
SP - 8
EP - 10
SN - 00368075
N1 - Accession Number: 85159884; THOMAS, PAUL J. 1; FAVERO, MARTIN S. 2; Affiliations: 1: Mayo Clinic, Rochester, Minnesota 55901; 2: Applied Microbiology and Planetary Quarantine Section, Center for Disease Control, Public Health Service, Phoenix, Arizona 85014; Issue Info: 1/ 7/1972, Vol. 175 Issue 4017, p8; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Wand, M.;
AU - Mather, J. A.;
T1 - Diphenylhydantoin intoxication mimicking botulism
CT - Diphenylhydantoin intoxication mimicking botulism
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/01/13/
VL - 286
IS - Jan 13
SP - 88
SN - 00284793
AD - reprints: Epidemiology Program, Center for Disease Control, Atlanta, Georgia 30333
AD - Epidemiology Program, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U. S. Department of Health, Education, and Welfare, and the Preventive Medicine Division, Idaho Department of Health, Boise, Idaho
N1 - Accession Number: 9-1369; Language: English; Trade Name: Marihuana; Generic Name: Cannabis; Chemical Name: Diphenylhydantoin--57-41-0 Cannabis--8063-14-7; Therapeutic Class: (28:12); AHFS Class: Anticonvulsants diphenylhydantoin; References: 8; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - Botulism-like symptoms were observed in 2 men who had ingested diphenylhydantoin-adulterated marihuana (cannabis). Two days before the onset of symptoms, they had ingested orally approximately 1 g. of marijuana, and one day later, each had smoked about 0.5 g. of marijuana. They denied having ingested any other drugs for several weeks before their illness. A toxicology serum screening test using thin layer and gas chromatography on the original samples of the patients' sera suggested the presence of a substance consistent with diphenylhydantoin. The patients' recovery was uneventful.
KW - Diphenylhydantoin--contamination-;
KW - Cannabis--contamination-;
KW - Contamination--diphenylhydantoin--of cannabis, results in botulism-like symptoms, in patients;
KW - Adulteration--cannabis--with diphenylhydantoin, results in botulism-like symptoms, in patients;
KW - Toxicity--diphenylhydantoin--contamination, of cannabis, results in botulism-like symptoms, in patients;
KW - Anticonvulsants--diphenylhydantoin--contamination, of cannabis, results in botulism-like symptoms, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Johnson, Donald W.
AU - Bernstein, Stuart
T1 - Classification of States Regarding Expanding Duties for Dental Auxiliaries and Selected Aspects of Dental Licensure -- 1970.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/02//
VL - 62
IS - 2
M3 - Article
SP - 208
EP - 215
PB - American Public Health Association
SN - 00900036
AB - A discussion is presented of the expanded functions of dental auxiliaries and the recognition of this development in terms of licensure. Further revision of dental practice acts is urged to meet the increasing demand for dental care. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Group dental practice
KW - Dental insurance
KW - Dental care
KW - Medical care
KW - Dental health maintenance organizations
KW - Dentistry
KW - Dentists
KW - Community dental services
KW - United States
N1 - Accession Number: 24294018; Johnson, Donald W. 1; Bernstein, Stuart 2; Affiliations: 1: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; 2: Division of Manpower Intelligence, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: Feb1972, Vol. 62 Issue 2, p208; Subject Term: Group dental practice; Subject Term: Dental insurance; Subject Term: Dental care; Subject Term: Medical care; Subject Term: Dental health maintenance organizations; Subject Term: Dentistry; Subject Term: Dentists; Subject Term: Community dental services; Subject: United States; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Edwards, C. C.;
T1 - Closing the gap: O-T-C drugs
CT - Closing the gap: O-T-C drugs
JO - FDA Pap.
JF - FDA Pap.
Y1 - 1972/02/01/
VL - 6
IS - Feb
SP - 4
EP - 8
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 10-1008; Language: English; Journal Coden: FDAPAL; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - An outline by which the FDA will review 25 categories of O-T-C drugs representing 100,000-500,000 products is presented. The agency will deal with all O-T-C drugs through rule-making that will establish, define, and describe therapeutic classes or categories of these products on an industry-wide basis. The parameters for each class will be outlined by means of a monograph.
KW - Drugs, over-the-counter--Food and Drug Administration (U.S.)--review, outline;
KW - Food and Drug Administration (U.S.)--drugs, over-the-counter--review, outline;
KW - Regulations--drugs, over-the-counter--review, FDA, outline;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1008&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chadduck, H. W.;
T1 - In brief summary: prescription drug advertising, 1962-71
CT - In brief summary: prescription drug advertising, 1962-71
JO - FDA Pap.
JF - FDA Pap.
Y1 - 1972/02/01/
VL - 6
IS - Feb
SP - 13
EP - 25
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 10-0764; Language: English; Journal Coden: FDAPAL; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - This article outlines FDA's position, interpretation, and policies concerning specific requirements of the law and regulations, and enunciates its general philosophy on regulation of the advertising of prescription drugs.
KW - Advertising--drugs--prescriptions, FDA regulations;
KW - Food and Drug Administration (U.S.)--advertising--drugs, prescriptions, regulations;
KW - Regulations--prescriptions--advertising, FDA;
KW - Laws--prescriptions--advertising, FDA regulations;
KW - Prescriptions--advertising--regulations, FDA;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kram, T. C.;
T1 - Separation of sulfa drugs by high speed liquid chromatography
CT - Separation of sulfa drugs by high speed liquid chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/02/01/
VL - 61
IS - Feb
SP - 254
EP - 256
SN - 00223549
AD - Food and Drug Administration, Brooklyn, New York 11232
N1 - Accession Number: 11-2329; Language: English; References: 9; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - The high speed liquid chromatographic behavior of 21 sulfonamides was studied. Analysis of the effect of the ionic strength of the mobile phase upon retention times and of concomitant effects on peak widths resulted in a scheme that can be applied to the separation of many combinations of sulfonamides.
KW - Sulfonamides--chromatography, liquid--high speed;
KW - Chromatography, liquid--sulfonamides--high speed;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Evans, J. R.;
AU - Yoder, P. D.;
T1 - Induced pseudomonas keratitis as related to cosmetics
CT - Induced pseudomonas keratitis as related to cosmetics
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1972/02/03/
VL - 23
IS - Feb 3
SP - 89
EP - 97
SN - 00379832
AD - Division of Toxicology and Division of Microbiology, Bureau of Foods, Food and Drug Administration, U. S. Department of Health, Education, and Welfare, Washington 20204
N1 - Accession Number: 9-3338; Language: English; References: 17; Journal Coden: JSCCA5; Section Heading: Toxicity; Microbiology; Abstract Author: Douglas L. Thompson
N2 - The potential hazard to consumers from the use of eye-area cosmetics contaminated with Pseudomonas aeruginosa was evaluated in rabbit and monkey eyes. The experimental conditions under which contamination of the conjunctival sacs of rabbit eyes with viable \IT/P. aeruginosa \OK/resulted in infection of the corneal stroma, keratitis and pyocyanic sequellae were investigated. It was shown that under conditions involving defined numbers of pseudomonas organisms and certain defects in the corneal epithelium, rabbit eyes developed pseudomonas keratitis. The effects appear to be more serious in rabbit eyes than in monkey eyes, and the sequence of destructive events progresses more rapidly in rabbits. It is not possible from these limited studies to say conclusively which species is more representative in man. Nevertheless, the effects are sufficiently similar in both species to warrant concern about their application to man, particularly with regard to current eye-decorating practices.
KW - Cosmetics--toxicity--potential, induced pseudomonas keratitis in rabbit and monkey eyes;
KW - Contamination--cosmetics--Pseudomonas aeruginosa, induced pseudomonas keratitis in rabbit and monkey eyes;
KW - Pseudomonas aeruginosa--contamination--cosmetics, induced keratitis in rabbit and monkey eyes;
KW - Toxicity--cosmetics--pseudomonas keratitis, induced, in rabbit and monkey eyes;
KW - Ophthalmic preparations--cosmetics--pseudomonas keratitis, induced, in rabbit and monkey eyes;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - CORREA-GIRON, PABLO
AU - CALISHER, CHARLES H.
AU - BAER, GEORGE M.
T1 - Epidemic Strain of Venezuelan Equine Encephalomyelitis Virus from a Vampire Bat Captured in Oaxaca, Mexico, 1970.
JO - Science
JF - Science
Y1 - 1972/02/04/
VL - 175
IS - 4021
M3 - Article
SP - 546
EP - 548
SN - 00368075
AB - A vampire bat, Desmodus rotundus, captured in Oaxaca, Mexico, in August 1970, was found to be infected with the epidemic strain of Venezuelan equine encephalomyelitis virus at the same time that an equine epizootic was occurring there. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85116742; CORREA-GIRON, PABLO 1; CALISHER, CHARLES H. 2; BAER, GEORGE M. 3; Affiliations: 1: Laboratorio de Microbiologia Experimental, Instituto Nacional de Investigaciones Pecuarias, Km. 151/212 Carretera a Toluca, Palo Alto, D.F., Mexico; 2: Arbovirus Unit, Virology Section, Laboratory Division, Center for Disease Control, U.S. Public Health Service, Atlanta, Georgia 30333; 3: Laboratory Investigations Unit, Viral Zoonoses Section, Epidemiology Program, Center for Disease Control, U.S. Public Health Service, Lawrenceville, Georgia 30245; Issue Info: 2/ 4/1972, Vol. 175 Issue 4021, p546; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ARCHER, VICTOR E.
T1 - Letters.
JO - Science
JF - Science
Y1 - 1972/02/25/
VL - 175
IS - 4024
M3 - Article
SP - 837
EP - 837
SN - 00368075
N1 - Accession Number: 87581281; ARCHER, VICTOR E. 1; Affiliations: 1: Division of Field Studies and Clinical Investigations, National Institute for Occupational Safety and Health, P.O. Box 8137, Salt Lake City, Utah 84108; Issue Info: 2/25/1972, Vol. 175 Issue 4024, p837; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Cradock, J. C.;
AU - Whitfield, G. R.;
AU - Menzie, J. W.;
AU - Fortner, C. L.;
T1 - Postadmission drug and allergy histories recorded by a pharmacist
CT - Postadmission drug and allergy histories recorded by a pharmacist
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1972/03/01/
VL - 29
IS - Mar
SP - 250
EP - 252
SN - 00029289
AD - Patient Care Pharmacy Service, Baltimore Cancer Research Center, NIH, C, NCI, U. S. Public Health Service Hospital, Baltimore, Maryland 21211
N1 - Accession Number: 9-1776; Language: English; References: 2; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - A system whereby pharmacists conduct drug and allergy history interviews on all patients admitted to a 50-bed cancer research unit is described. Some findings from the first 142 interviews are discussed. A case study of a 54-year-old white male with malignant melanoma and severe renal impairment is presented. The patient's laboratory values and drug therapy are discussed in relation to his renal impairment. The authors conclude that patient drug and allergy history interviews conducted by a pharmacist are superior to having a patient complete a prepared questionnaire.
KW - Patient information--medical histories--hospitals, postadmission drug and allergy histories by pharmacists;
KW - Hospitals--patient information--medical histories, postadmission drug and allergy histories by pharmacists;
KW - Pharmacists, hospital--patient information--medical histories, postadmission drug and allergy histories;
KW - Drugs--and allergies--patient information, medical histories, hospitals, postadmission, by pharmacists;
KW - Allergies--and drugs--patient information, medical histories, hospitals, postadmission, by pharmacists;
KW - Drug information--patients--postadmission drug and allergy histories by pharmacists;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jennings, J.;
T1 - Regulatory aspects of parenteral drugs
CT - Regulatory aspects of parenteral drugs
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1972/03/01/
VL - 26
IS - Mar-Apr
SP - 53
EP - 57
AD - Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 10-0450; Language: English; Journal Coden: BUYRAI; Section Heading: Legislation, Laws and Regulations
N2 - Problem areas in the manufacture and administration of parenterals include the recognition of the need for a total concept of sterility; the hazard potential of particulate matter; the addition of other drugs to large volume parenterals prior to their administration; and packaging designs for large volume parenterals. It was proposed that a study be undertaken under the auspices of the official compendia with the cooperation of the industry of these problem areas.
KW - Injections--manufacturing--and administration, regulatory aspects;
KW - Regulations--injections--manufacturing, and administration;
KW - Manufacturing--injections--regulations, discussion;
KW - Drug administration--injections--regulations, discussion;
KW - Industry, pharmaceutical--injections--manufacturing, regulatory aspects;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J. E.
T1 - Studies on IgA of the Guinea-Pig.
JO - Immunology
JF - Immunology
Y1 - 1972/03//
VL - 22
IS - 3
M3 - Article
SP - 333
EP - 345
SN - 00192805
AB - The secretory immunoglobulin of the guinea-pig, IgA, was antigenically unique when compared with the 7Sγ1-, 7Sγ2- and γM-globulins, although it did share Fab determinants in common with the 7S&gamma2 globulin. Specific antigen binding capacity was detected in serum IgA after sequential oral and parenteral sensitization with purified protein antigens. IgA was prominent in saliva and succus entericus; in colostrum its concentration was 4–8 times that in normal serum. IgA in serum and secretory fluids sedimented at similar rates (≈12S), although colostral IgA contained an additional ≈16S population. Serum and secretory IgA appeared antigenically identical, however, serum IgA was especially sensitive to mild reductive procedures and became ≈7S after treatment. Serum IgA migrated as a β-protein on electrophoresis and was faster than IgA of colostrum. Antisera to IgA were produced by a procedure which involved simple precipitation of secretory IgA with an antiserum containing antibodies to common determinants of guinea-pig Ig. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - PROTEINS
KW - SPUTUM
KW - COLOSTRUM
KW - IMMUNE serums
N1 - Accession Number: 14514637; Coe, J. E. 1; Source Information: Mar72, Vol. 22 Issue 3, p333; Subject: ANTIGENS; Subject: IMMUNOGLOBULINS; Subject: PROTEINS; Subject: SPUTUM; Subject: COLOSTRUM; Subject: IMMUNE serums; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
AU - Proctor, J. B.;
T1 - Effects of solvent composition on the partition of amines: extraction of the free base
CT - Effects of solvent composition on the partition of amines: extraction of the free base
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/03/01/
VL - 55
IS - Mar
SP - 328
EP - 331
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3971; Language: English; Chemical Name: Amphetamine--300-62-9 Chlorpheniramine--132-22-9 Codeine--6059-47-8 Quinine--130-95-0 Dextromethorphan--125-71-3; References: 8; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Extraction constants are given for the free bases of 20 pharmaceutical amines in a water and chloroform-isooctane system. The variation of extraction with solvent composition is nonlinear and may be described by an exponential function in which the value of the exponent is related empirically to the extraction in the pure solvents. Drugs studied included amphetamine, codeine, dextromethorphan, chlorpheniramine and quinine.
KW - Amphetamine--extraction-;
KW - Chlorpheniramine--extraction-;
KW - Codeine--extraction-;
KW - Quinine--extraction-;
KW - Dextromethorphan--extraction-;
KW - Drugs--amines--partitioning, effects of solvent composition on free base extraction;
KW - Extraction--amines--bases, free, effects of solvent composition on partitioning;
KW - Partition coefficients--amines--bases, free, effects of solvent composition on partitioning;
KW - Solvents--amines--composition, effects on partitioning;
KW - Amines--extraction--constants, effects of solvent composition on partitioning of free base;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hall, R. J.;
AU - Levine, J.;
T1 - Partition chromatography of barbiturates in combinations with salicylamide and other drugs
CT - Partition chromatography of barbiturates in combinations with salicylamide and other drugs
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/03/01/
VL - 55
IS - Mar
SP - 332
EP - 334
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3972; Language: English; Chemical Name: Salicylamide--65-45-2 Amobarbital--57-43-2 Pentobarbital--76-74-4 Butabarbital--125-40-6; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics amobarbital (28:24); AHFS Class: Sedatives and hypnotics pentobarbital (28:24); AHFS Class: Sedatives and hypnotics butabarbital; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Barbiturates can be separated from salicylamide by trapping the latter on a partition chromatographic column in which ferric chloride or ferric chloride-urea is the immobile phase, isooctane-ether mixtures are the mobile phase. Experimental conditions must be selected in accord with the partition characteristics of the individual barbiturate. Analyses are presented of commercial preparations of amobarbital, pentobarbital, and butabarbital with salicylamide together with a variety of other drugs.
KW - Salicylamide--combination, barbiturates-;
KW - Amobarbital--chromatography-;
KW - Pentobarbital--chromatography-;
KW - Butabarbital--chromatography-;
KW - Chromatography--partition--barbiturates, in combination with salicylamide and other drugs;
KW - Barbiturates--chromatography--partition, in combination with salicylamide and other drugs;
KW - Sedatives and hypnotics--amobarbital--chromatography, partition, in combination with salicylamide and other drugs;
KW - Sedatives and hypnotics--pentobarbital--chromatography, partition, in combination with salicylamide and other drugs;
KW - Sedatives and hypnotics--butabarbital--chromatography, partition, in combination with salicylamide and other drugs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Waters, J. A.;
AU - Kondo, Y.;
AU - Witkop, B.;
T1 - Photochemistry of steroids
CT - Photochemistry of steroids
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/03/01/
VL - 61
IS - Mar
SP - 321
EP - 334
SN - 00223549
AD - Laboratory of Chemistry, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland 20014
N1 - Accession Number: 11-4487; Language: English; References: 128; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - Photorearrangements, photoadditions, photoreductions, and photooxidations are discussed in this review on the photochemistry of steroids. Numerous reactions are described, and the approaches are often applicable to other models besides steroids.
KW - Steroids--photochemistry--review;
KW - Photochemistry--steroids--review;
KW - Stability--steroids--photochemistry, review;
KW - Oxidation--steroids--photo, review of photochemistry;
KW - Reduction--steroids--photo, review of photochemistry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J.;
AU - Medwick, T.;
T1 - Identification of sulfonamides by NMR spectroscopy
CT - Identification of sulfonamides by NMR spectroscopy
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/03/01/
VL - 61
IS - Mar
SP - 434
EP - 443
SN - 00223549
AD - Food and Drug Administration, New York District, U.S. Department of Health, Education, and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 11-4047; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Spectrometry, nuclear magnetic resonance--sulfonamides--identification;
KW - Sulfonamides--spectrometry, nuclear magnetic resonance--identification;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rippere, R. A.;
AU - Arret, B.;
T1 - Automated turbidimetric microbiological assay readout system
CT - Automated turbidimetric microbiological assay readout system
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/03/01/
VL - 61
IS - Mar
SP - 449
EP - 454
SN - 00223549
AD - Microbiological Assay Branch, National Center for Antibiotics Analysis, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-4530; Language: English; Journal Coden: JPMSAE; Section Heading: Methodology; Pharmaceutical TechnologyMicrobiology
KW - Automation--turbidimetry--microbiological assay readout system;
KW - Turbidimetry--automation--microbiological assay readout system;
KW - Analysis--microbiological--turbidimetry, automated readout system;
KW - Microbiology--turbidimetry--automated readout system;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1973-09612-001
AN - 1973-09612-001
AU - Greenberg, Jerome H.
T1 - Venereal disease in the armed forces.
JF - Medical Aspects of Human Sexuality
JO - Medical Aspects of Human Sexuality
JA - Med Aspects Hum Sex
Y1 - 1972/03//
VL - 6
IS - 3
SP - 164
EP - 201
CY - US
PB - Hospital Publications, Inc.
SN - 0025-7001
N1 - Accession Number: 1973-09612-001. Partial author list: First Author & Affiliation: Greenberg, Jerome H.; Dept. of U.S. Army, Health & Environment Office of the Surgeon General, Washington, D.C. Release Date: 19730501. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Military Personnel; Sexually Transmitted Diseases; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300); Military Psychology (3800). Population: Human (10). Page Count: 38. Issue Publication Date: Mar, 1972.
AB - Presents an historical review of venereal disease in the armed forces from 1778 to the present, including incidence, treatment, and preventive measures, especially in the army. Currently, routine prophylaxis is limited to the condom, with recommended treatment for acute gonorrheal urethritis in the male an initial intramuscular injection of 2.4 million units of aqueous procaine penicillin. For syphilis, 2 doses of 2.4 million units of benzathine penicillin, a week apart, is recommended. The effect of veneral disease incidence is summarized as much less today than in the past. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - incidence & treatment
KW - venereal disease
KW - armed forces personnel from 1778 to present
KW - 1972
KW - Military Personnel
KW - Sexually Transmitted Diseases
KW - Treatment
KW - 1972
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1972-27661-001
AN - 1972-27661-001
AU - Shore, James H.
AU - Bopp, John F.
AU - Waller, Thelma R.
AU - Dawes, James W.
T1 - A suicidal prevention center on an Indian reservation.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1972/03//
VL - 128
IS - 9
SP - 1086
EP - 1091
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1972-27661-001. PMID: 5060823 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Shore, James H.; Portland Area Indian Health Service, Ore. Release Date: 19721001. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcoholism; Community Services; Ethnology; Mental Illness (Attitudes Toward); Suicide. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 6. Issue Publication Date: Mar, 1972.
AB - Describes the background and development of a suicide prevention service on an Indian reservation and emphasizes the importance of community acceptance and involvement. In the 1st 13 mo. of operation the center had 36 admissions including 30 Indian patients. Characteristics of the patient population are analyzed: (a) the average age was 24 yr., (b) 57% were male, (c) 75% of all admissions were associated with alcohol or inhalant abuse, and (d) 30 admissions were for suicide threats or attempts. It is stressed that, for mental health consultants, the importance of timing and an understanding of the complexities of the sociopolitical milieu are essential in supporting the development of such a project. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention center
KW - importance community involvement & sociopolitical milieu
KW - characteristics of patient population
KW - Indian reservation
KW - 1972
KW - Alcoholism
KW - Community Services
KW - Ethnology
KW - Mental Illness (Attitudes Toward)
KW - Suicide
KW - 1972
DO - 10.1176/ajp.128.9.1086
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KOLBYE JR., ALBERT C.
T1 - Mercury Residues.
JO - Science
JF - Science
Y1 - 1972/03/17/
VL - 175
IS - 4027
M3 - Article
SP - 1192
EP - 1192
SN - 00368075
N1 - Accession Number: 85198713; KOLBYE JR., ALBERT C. 1; Affiliations: 1: Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204; Issue Info: 3/17/1972, Vol. 175 Issue 4027, p1192; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SAROFF, H. A.
AU - MINTON, ALLEN P.
T1 - The Hill Plot and the Energy of Interaction in Hemoglobin.
JO - Science
JF - Science
Y1 - 1972/03/17/
VL - 175
IS - 4027
M3 - Article
SP - 1253
EP - 1255
SN - 00368075
AB - The Hill plot does not independently yield the average free energy of interaction per binding site, as has been proposed by Wyman, but rather the diflerence between the free energies of interaction on binding the first and last ligands. It is shown that additional data (or assumptions) and a model for cooperative behavior are requtired to obtain the average free energy of interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198745; SAROFF, H. A. 1; MINTON, ALLEN P. 1; Affiliations: 1: National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Bethesda, Maryland 20014; Issue Info: 3/17/1972, Vol. 175 Issue 4027, p1253; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CONSTANTINE, DENNY G.
AU - EMMONS, RICHARD W.
AU - WOODIE, JAMES D.
T1 - Rabies Virus in Nasal Mucosa of Naturally Infected Bats.
JO - Science
JF - Science
Y1 - 1972/03/17/
VL - 175
IS - 4027
M3 - Article
SP - 1255
EP - 1256
SN - 00368075
AB - Rabies virus was demonstrated in the olfactory mucosa of naturally infected bats by staining with fluorescent antibody and by isolation of the virus from the nasal tissues. The olfactory mucosa is a potential portal of entry and exit for airborne rabies virus in bat caves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85198746; CONSTANTINE, DENNY G. 1,2; EMMONS, RICHARD W. 3; WOODIE, JAMES D. 3; Affiliations: 1: Naval Biomedical Research Laboratory, Naval Supply Center, Oakland, California 94625; 2: Center for Disease Control, Public Health Service, Atlanta, Georgia 30333; 3: Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley 94704; Issue Info: 3/17/1972, Vol. 175 Issue 4027, p1255; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - TESH, ROBERT B.
AU - CHANIOTIS, BYRON N.
AU - JOHNSON, KARL M.
T1 - Vesicular Stomatitis Virus (Indiana Serotype): Transovarial Transmission by Phlebotomine Sandflies.
JO - Science
JF - Science
Y1 - 1972/03/31/
VL - 175
IS - 4029
M3 - Article
SP - 1477
EP - 1479
SN - 00368075
AB - Transovarial transmission of vesicular stomatitis virus (Indiana sero-type) by experimentally infected Lutzomyia trapidoi and Lutzomyia ylephiletrix to their progeny was demonstrated. Virus was recovered from all developmental stages; mean virus titers from egg to first generation adult showed a four-log increase, indicating that virus multiplication occurred during development of the sandflies. Virus titers in first generation adult females were comparable to those found in their parents. These infected female sandflies transmitted vesicular stoma titus virus Indiana by bite to susceptible animals and transmitted the virus transovarially to their offspring (second generation). Results demonstrate a possible mechanism for transmission and maintenance of this virus in nature without a vertebrate (heat) host reservoir. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85160069; TESH, ROBERT B. 1; CHANIOTIS, BYRON N. 1; JOHNSON, KARL M. 1; Affiliations: 1: U.S. Public Health Service, National Institute of Allergy and infectious Diseases, Middle America Research Unit, Balboa Heights, Canal Zone; Issue Info: 3/31/1972, Vol. 175 Issue 4029, p1477; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Goldman, G.;
AU - Fortner, C. L.;
AU - Cradock, J.;
AU - Murray, B.;
AU - Hsieh, R.;
AU - \ET/;
T1 - Computer-based medication system for cancer chemotherapy patients
CT - Computer-based medication system for cancer chemotherapy patients
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1972/04/01/
VL - 29
IS - Apr
SP - 305
EP - 311
SN - 00029289
AD - U. S. Public Health Service Hospital, Baltimore, Maryland 21211
N1 - Accession Number: 9-3303; Language: English; References: 5; Journal Coden: AJHPA9; Section Heading: Information Processing and Literature
N2 - A convenient method for recording clinical drug administration data for later processing, storage and retrieval is described. A single form is used to satisfy the needs of health care team members. The physician writes each drug order on a separate form. The form is comprised of an original and 3 carbon copies. The original is used as an input medium for the computer, one copy is placed in the medical chart, another copy supplies the pharmacist with an order for unit-of-use medications and a third copy provides the nurse with a medicine card in the physician's handwriting. The nurse administers and charts medications without further transcribing. Written information on the form is typed using a regular IBM Selectric typewriter. Another area of #OQ#OQmark-sense'' data is entered by using a pen to fill in a matrix of preprinted boxes. Optical character recognition equipment scans the typed and mark-sense input to supply information for computer purposes. Two reports are presently generated by the computer\M/a weekly drug report which gives complete individual and cumulative drug information for all patients and a weekly drug utilization report subdivided by route of administration, number of units administered, doses and total dosage. This system has been in use for 2 years. While achieving a high level of acceptance from nurses and physicians, the drug form has supplanted a previously used medication system with multiple inherent weaknesses. The pharmacist is instrumental in all phases of information flow, from medication form to the final reports, and provides the physician with information previously not easily made available.
KW - Automation, data processing--computers--based medication system, recording clinical drug administration data for later processing and retrieval;
KW - Drug administration--automation, data processing--recording clinical drug administration data for later processing and retrieval;
KW - Drug information--automation, data processing--recording clinical drug administration data for later processing and retrieval;
KW - Patient information--automation, data processing--recording clinical drug administration data for later processing and retrieval;
KW - Records--drug administration--automation, data processing, recording clinical drug administration data for later processing and retrieval;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hazell, Joseph William
AU - Hodges, Fred B.
AU - Cunningham, George C.
T1 - Intermediate Benefit Analysis -- Spencer's Dilemma and School Health Services.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/04//
VL - 62
IS - 4
M3 - Article
SP - 560
EP - 565
PB - American Public Health Association
SN - 00900036
AB - The recurrent decision-making dilemma of compromise between the desire for total scientific analysis, which is impractical under the constraints of reality, and the inclination to use simple intuition is examined in connection with an actual decision regarding the funding of school health services in California. A resolution is described in terms of the cost analysis of intermediate benefits rather than ultimate benefits. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - School health services
KW - Medical care
KW - Pediatrics
KW - School nursing
KW - Decision making
KW - California
N1 - Accession Number: 24294103; Hazell, Joseph William 1; Hodges, Fred B. 2; Cunningham, George C. 3; Affiliations: 1: Dental Health Center, U. S. Public Health Service, 14th Avenue and Lake Street, San Francisco, California 94118; 2: Charge of the Preschool and School Health Unit, 2151 Berkeley Way, Berkeley, California 94704; 3: Chief of the Bureau of Maternal and Child Health, California State Department of Public Health, 2151 Berkeley Way, Berkeley, California 94704; Issue Info: Apr1972, Vol. 62 Issue 4, p560; Subject Term: School health services; Subject Term: Medical care; Subject Term: Pediatrics; Subject Term: School nursing; Subject Term: Decision making; Subject: California; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Armstrong, G. D.;
T1 - Vitamin ingestions (poisoning)
CT - Vitamin ingestions (poisoning)
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1972/04/01/
VL - Pages
IS - Apr-Jun
SP - 1
EP - 6
AD - U.S. Department of Health, Education and Welfare, Public Health Service, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3865; Language: English; Journal Coden: NCPBBY; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2 - Poisoning in adults and children, due to the ingestion of overdoses of vitamin preparations, is discussed. It is noted that vitamins have been exceeded only by aspirin in the numbers of ingestions reported to the Clearinghouse. Vitamin overdose is most common in children between 1 and 3 years of age. After age 3 there is an abrupt decrease in the number of overdoses. Except where high doses of vitamins A and D or iron are taken, the patients usually recover following discontinuance of the drug.
KW - Poisoning--vitamins--discussion;
KW - Vitamins--poisoning--discussion;
KW - Pediatrics--vitamins--poisoning, discussion;
KW - Toxicity--vitamins--poisoning, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pines, W. L.;
T1 - Hexachlorophene story
CT - Hexachlorophene story
JO - FDA Pap.
JF - FDA Pap.
Y1 - 1972/04/01/
VL - 6
IS - Apr
SP - 11
EP - 14
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 10-0762; Language: English; Chemical Name: Hexachlorophene--70-30-4; Journal Coden: FDAPAL; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - Recent requlatory actions regarding indications and use of hexachlorophene and the clinical studies from which these actions grew are discussed.
KW - Hexachlorophene--regulations-;
KW - Regulations--hexachlorophene--Food and Drug Administration (U.S.), discussion;
KW - Food and Drug Administration (U.S.)--hexachlorophene--regulations, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Goldwitz, B. A.;
T1 - Determination of chloral hydrate in soft gelatin capsules by NMR
CT - Determination of chloral hydrate in soft gelatin capsules by NMR
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/04/01/
VL - 61
IS - Apr
SP - 613
EP - 615
SN - 00223549
AD - New York District Laboratories, U.S. Dept. of HEW, Food and Drug Administration, Brooklyn, New York 11232
N1 - Accession Number: 12-0161; Language: English; Chemical Name: Chloral hydrate--302-17-0; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics chloral hydrate; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Chloral hydrate--spectrometry, nuclear magnetic resonance-;
KW - Spectrometry, nuclear magnetic resonance--chloral hydrate--capsules, soft gelatin;
KW - Sedatives and hypnotics--chloral hydrate--spectrometry, nuclear magnetic resonance, soft gelatin capsules;
KW - Capsules--gelatin--soft, chloral hydrate, NMR spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Pedersen, A. H. B.;
AU - Wiesner, P. J.;
AU - Holmes, K. K.;
AU - Johnson, C. J.;
AU - Turck, M.;
T1 - Spectinomycin and penicillin G in the treatment of gonorrhea: a comparative evaluation
CT - Spectinomycin and penicillin G in the treatment of gonorrhea: a comparative evaluation
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/04/10/
VL - 220
IS - Apr 10
SP - 205
EP - 208
AD - Seattle-King County Health Department, Department of Medicine, U. S. Public Health Service Hospital; and the University of Washington School of Medicine, Seattle, Washington 98114
N1 - Accession Number: 9-2996; Language: English; Chemical Name: Spectinomycin--1695-77-8 Penicillin G--61-33-6; Therapeutic Class: (8:12); AHFS Class: Antibiotics spectinomycin (8:12); AHFS Class: Antibiotics penicillin G; References: 13; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - This study concerns a controlled comparison of spectinomycin HCl and penicillin G procaine in the treatment of uncomplicated gonorrhea in men and women. Patients received either 2.0 g. or 4.0 g. of spectinomycin HCl or currently recommended doses of penicillin G procaine. Of 172 men reexamined within 7 days after treatment of gonococcal urethritis, treatment failure rates were 17% for 2.4 megaunits of penicillin, 0% for 2 g. of spectinomycin and 3.4% for 4 g. of spectinomycin. Of 143 women, failure rates were 13% for 4.8 megaunits of penicillin, 4.3% for 2 g. of spectinomycin, and 4.7% for 4 g. of spectinomycin. Spectinomycin appeared to be well tolerated and was found to be significantly more effective than penicillin G procaine. It is not known at present whether strains of \IT/N. gonorrhoeae \OK/causing clinical infections will eventually develop absolute resistance to spectinomycin. Caution should be observed when spectinomycin is used in gonorrhea therapy, since it does not cure subclinical incubating syphilis.
KW - Spectinomycin--hydrochloride-;
KW - Penicillin G--procaine-;
KW - Antibiotics--spectinomycin--hydrochloride, gonorrhea, therapy, in patients, superior to penicillin G procaine;
KW - Antibiotics--penicillin G--procaine, gonorrhea, therapy, in patients, compared to spectinomycin hydrochloride;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Challop, R.;
AU - McCabe, E.;
AU - Reece, R.;
T1 - Breaking the childhood lead poisoning cycle\M/a program for community casefinding and self-help
CT - Breaking the childhood lead poisoning cycle\M/a program for community casefinding and self-help
JO - Am. J. Pub. Health
JF - Am. J. Pub. Health
Y1 - 1972/05/01/
VL - 62
IS - May
SP - 655
EP - 657
AD - Bureau of Community Environmental Management, Public Health Service, Cincinnati, Ohio
N1 - Accession Number: 10-1391; Language: English; Journal Coden: AJPEAG; Section Heading: Environmental Toxicity; Abstract Author: Diorita C. Fletcher
N2 - Childhood lead poisoning continues to be a major problem among children in urban centers. Federal, local and private agencies have joined forces to combat childhood lead poisoning in Cincinnati, Ohio and Norfolk, Virginia. These efforts, as well as recent technological advances in lead detection in children and housing units, have enabled the Public Health Service to establish guidelines for the development of comprehensive community lead poisoning control programs.
KW - Poisoning--lead--pediatrics, detection and control;
KW - Lead--poisoning--pediatrics, detection and control;
KW - Control--poisoning--lead, pediatrics, and detection;
KW - Pediatrics--lead--poisoning, detection and control;
KW - Toxicity, environmental--lead--poisoning, pediatrics, detection and control;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Challop, Roger
AU - McCabe, Edward
AU - Reece, Robert
T1 - Breaking the Childhood Lead Poisoning Cycle -- A Program for Community Casefinding and Self-Help.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/05//
VL - 62
IS - 5
M3 - Article
SP - 655
EP - 657
SN - 00900036
AB - Lead poisoning control activities developed by coordination of federal, locale and private agencies in Cincinnati and Norfolk were intended to check Public Health Service guidelines, It has been shown that sectors can work together effectively. Programs are described. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Environmental health
KW - Health risk assessment
KW - Lead poisoning in children
KW - Pediatric toxicology
KW - Human services
KW - Medical care
KW - Preventive medicine
KW - Public welfare
N1 - Accession Number: 24294134; Challop, Roger 1; McCabe, Edward 1; Reece, Robert 2; Affiliations: 1: Pediatric Consultants, Bureau of Community Environmental Management, Public Health Service, Cincinnati, Ohio; 2: Director, Outpatient Department, Children's Hospital, Cincinnati, Ohio; Issue Info: May1972, Vol. 62 Issue 5, p655; Thesaurus Term: Public health; Thesaurus Term: Environmental health; Thesaurus Term: Health risk assessment; Subject Term: Lead poisoning in children; Subject Term: Pediatric toxicology; Subject Term: Human services; Subject Term: Medical care; Subject Term: Preventive medicine; Subject Term: Public welfare; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Foster, S. O.;
AU - Brink, E. W.;
AU - Hutchins, D. L.;
AU - Pifer, J. M.;
AU - Lourie, B.;
AU - \ET/;
T1 - Human monkeypox
CT - Human monkeypox
JO - Bull. WHO
JF - Bull. WHO
Y1 - 1972/05/01/
VL - 46
IS - May
SP - 569
EP - 576
AD - Bureau of Preventative Medicine, National Public Health Service, Republic of Liberia, Monrovia, Liberia
N1 - Accession Number: 10-1716; Language: English; Language of Summary: fr; References: 21; Journal Coden: BWHOA6; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Between October 1970 and May 1971, 6 cases of monkeypox virus in unvaccinated individuals were identified in Liberia, Nigeria, and Sierra Leone; 4 of the cases were confirmed by virus isolation and 2 were diagnosed on the basis of epidemiological and serological investigation. Postinfection serological studies showed high haemagglutination inhibition and neutralizing titers to pox group virus in 4 of the cases. Repeated challenge vaccination of all cases with potent smallpox vaccine resulted in equivocal reactions. In all, 24 susceptible household contacts were exposed to the infected cases, but none developed disease. All the contacts subsequently responded to vaccination with a primary reaction, thus confirming their susceptibility and ruling out any asymptomatic infection.
KW - Smallpox vaccines--immunization-;
KW - Immunization--smallpox--monkeypox patients, and contacts, in West Africa;
KW - Monkeypox--immunization--smallpox vaccines, patients, in West Africa;
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DP - EBSCOhost
DB - ipa
ER -
TY -
AU - Schwartz, William F.1
T1 - What Can Schools Do about the Increasing VD Problem?
JO - Education Digest
JF - Education Digest
J1 - Education Digest
PY - 1972/05//
Y1 - 1972/05//
VL - 37
IS - 9
CP - 9
M3 - Article
SP - 43
EP - 45
SN - 0013127X
AB - The article focuses on the role of schools in spreading awareness about venereal diseases (VD). VD is not any one specific disease. Venereal is a general term for diseases caused by certain germs that normally cannot survive for long outside the human body. Because of the public condemnation of the VD victims, it has been found necessary in 49 states to pass laws permitting physicians to diagnose and treat minors for venereal disease without the knowledge or consent of their parents. Today's young people don't know nearly as much as they should about venereal diseases. Many middle schools and high schools are not teaching anything about them, and in many others it's very sporadic. There's too much of a tendency to confuse venereal disease education with sex education. In some places, the young people themselves have taken on the responsibility for education of their peers. Another step which might be taken by local school groups is much easier. It involves the use of two very simple reading materials: handouts and a poster to be placed on bulletin boards of schools.
KW - Schools
KW - Posters
KW - Sexually transmitted diseases -- Study & teaching
KW - Sexually transmitted diseases -- Patients
KW - Stigma (Social psychology)
KW - Therapeutics
KW - Medical laws & legislation
N1 - Accession Number: 18696498; Authors: Schwartz, William F. 1; Affiliations: 1: Educational Consultant, Venereal Disease Branch, Center for Disease Control, U.S. Public Health Service, Washington, D.C.; Subject: Sexually transmitted diseases -- Study & teaching; Subject: Schools; Subject: Sexually transmitted diseases -- Patients; Subject: Stigma (Social psychology); Subject: Therapeutics; Subject: Medical laws & legislation; Subject: Posters; Number of Pages: 3p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
TY - GEN
AU - Smith, D. J.;
T1 - Ion exchange method for the separation and spectrophotometric determination of some sympathomimetic amines, antihistamines, and phenothiazines in pharmaceuticals
CT - Ion exchange method for the separation and spectrophotometric determination of some sympathomimetic amines, antihistamines, and phenothiazines in pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/05/01/
VL - 55
IS - May
SP - 596
EP - 609
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 9-3266; Language: English; References: 8; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - An ion exchange procedure has been developed for the separation and quantitative analysis of 32 drugs in various combinations.
KW - Chromatography--ion exchange--drugs, in dosage forms, sympathomimetics, antihistamines and phenothiazines;
KW - Sympathomimetic agents--chromatography--ion exchange and spectrometry, in dosage forms;
KW - Antihistamines--chromatography--ion exchange and spectrometry, in dosage forms;
KW - Phenothiazines--chromatography--ion exchange and spectrometry, in dosage forms;
KW - Spectrometry--drugs--dosage forms, sympathomimetic agents, antihistamines and phenothiazines;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Douglas, C. C.;
T1 - Gas chromatographic determination of phenolic compounds in drug preparations: collaborative study
CT - Gas chromatographic determination of phenolic compounds in drug preparations: collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/05/01/
VL - 55
IS - May
SP - 610
EP - 612
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 9-3075; Language: English; Chemical Name: Phenol--108-95-2; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A gas chromatographic method for the determination of phenol, methyl salicylate, menthol, and camphor in drug preparations was studied collaboratively by 9 laboratories. Mean recoveries were: phenol 98.2, 106.0, and 103.6%; methyl salicylate 103.9, 102.0, and 101.9%; menthol 102.9 and 100.9%; and camphor 101.9 and 100.9%.
KW - Phenol--and phenolic compounds-;
KW - Chromatography, gas--phenol--and phenolic compounds, in dosage forms;
KW - Dosage forms--phenol--and phenolic compounds, GLC;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hall, R. J.;
AU - Farber, T.;
T1 - Determination of bismuth and body tissues and fluids after administration of controlled doses
CT - Determination of bismuth and body tissues and fluids after administration of controlled doses
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/05/01/
VL - 55
IS - May
SP - 639
EP - 642
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 9-3287; Language: English; Chemical Name: Bismuth--7440-69-9; Therapeutic Class: (56:04); AHFS Class: Antacids bismuth; References: 6; Journal Coden: JANCA2; Section Heading: Drug Metabolism and Body Distribution; BiopharmaceuticsDrug Analysis; Abstract Author: Douglas L. Thompson
N2 - Reported is a study of the controlled dosage of bismuth salts to dogs and the atomic absorption analysis of bismuth levels in the serum, urine, spleen, muscle, lymph, kidney, and liver. A direct positive correlation is shown between the water solubility of the salt administered and the level of bismuth found in the tissues and fluids.
KW - Bismuth--spectrometry-;
KW - Metabolism--bismuth--spectrometry, atomic absorption, body tissues and fluids, in dogs;
KW - Drugs, body distribution--bismuth--spectrometry, atomic absorption, body tissues and fluids, in dogs;
KW - Antacids--bismuth--spectrometry, atomic absorption, body tissues and fluids, in dogs;
KW - Spectrometry--atomic absorption--bismuth, in body tissues and fluids, in dogs;
KW - Blood levels--bismuth--spectrometry, atomic absorption, in dogs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheppard, A. J.;
AU - Hubbard, W. D.;
AU - Prosser, A. R.;
T1 - Comparison of gas chromatographic calibration methods for analysis of menadione and menadione sodium bisulfite content of pharmaceutical products
CT - Comparison of gas chromatographic calibration methods for analysis of menadione and menadione sodium bisulfite content of pharmaceutical products
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/05/01/
VL - 55
IS - May
SP - 660
EP - 661
AD - Division of Nutrition, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 9-3267; Language: English; Chemical Name: Menadione--58-27-5; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A comparative study was made of 2 GLC calibration methods for determining the menadione and menadione sodium bisulfite content of pharmaceuticals. One method utilizes an external standard and the second method makes use of butylated hydroxyanisole as an internal standard. Measurements were made on 8 pure solutions of known concentration of menadione and on 5 pharmaceuticals containing menadione or menadione sodium bisulfite. No significant difference was found between the results obtained by the 2 methods.
KW - Menadione--and menadione sodium bisulfite-;
KW - Chromatography, gas--menadione--and menadione sodium bisulfite, gas chromatography of dosage forms;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Castells, S.;
AU - Inamdar, S.;
AU - Baker, R.;
AU - Wallach, S.;
T1 - Effects of porcine calcitonin in osteogenesis imperfecta tarda
CT - Effects of porcine calcitonin in osteogenesis imperfecta tarda
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1972/05/01/
VL - 80
IS - May
SP - 757
EP - 762
SN - 00223476
AD - Departments of Pediatrics and Medicine and the United States Public Health Service, Clinical Research Center, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203
N1 - Accession Number: 10-1247; Language: English; Chemical Name: Calcitonin--9007-12-9; References: 15; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - In this report of 2 children with osteogenesis imperfecta tarda, the effects of the administration of porcine calcitonin were evaluated by means of calcium and phosphorus balance studies, urinary hydroxyproline excretion, tubular reabsorption of phosphorus, and phosphate clearance before and after the administration of parathyroid extract. The balance studies indicated that calcitonin was effective in causing retention of calcium and phosphorus and decrease in hydroxyproline excretion. These improvements suggest that calcitonin may be of therapeutic value in osteogenesis imperfecta by decreasing bone resorption.
KW - Calcitonin--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Verhulst, H. L.;
T1 - Impact of the Poison Prevention Packaging Act on drug containers
CT - Impact of the Poison Prevention Packaging Act on drug containers
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1972/05/01/
VL - 38
IS - May
SP - 52
EP - 55
SN - 00030627
AD - Division of Chemical Hazards, Bureau of Product Safety, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 10-0448; Language: English; Journal Coden: PYTMAO; Section Heading: Legislation, Laws and Regulations; Abstract Author: Walter F. Stanaszek
N2 - Implications of the Poison Prevention Packaging Act for pharmacists are discussed in terms of what the law encompasses, exceptions which can be made, and time requirements for compliance with the Act. Household substances included in the Act are: (1) hazardous substances as defined in the Hazardous Substances Act; (2) economic poisons as defined in the Federal Insecticide, Fungicide, and Rodenticide Act; (3) a food, drug or cosmetic as defined in the Food, Drug and Cosmetic Act; and (4) fuel stored in a portable container. Because 50% of child poisoning ingestions involve pharmaceuticals, success of the new legislation and encouragement of physicians and patients to accept the use of special packaging will be largely dependent upon pharmacist efforts.
KW - Poison Prevention Packaging Act--impact--on drug containers, and implications for pharmacists;
KW - Laws--Poison Prevention Packaging Act--impact, on drug containers, and implications for pharmacists;
KW - Containers--drugs--impact, of Poison Prevention Packaging Act;
KW - Pharmacists--implications--of Poison Prevention Packaging Act;
KW - Packaging--poisons--Poison Prevention Packaging Act, impact on drug containers and implications for pharmacists;
KW - Poisons--packaging--Poisons Prevention Packaging Act, impact on drug containers and implications for pharmacists;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-0448&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1972-31841-001
AN - 1972-31841-001
AU - Shore, James H.
AU - Von Fumetti, Billee
T1 - Three alcohol programs for American Indians.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1972/05//
VL - 128
IS - 11
SP - 1450
EP - 1454
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1972-31841-001. PMID: 5067254 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Shore, James H.; Portland Area Indian Health Service, Mental Health Office, Ore. Release Date: 19721201. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcoholism; Ethnology; Evaluation; Rehabilitation. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 5. Issue Publication Date: May, 1972.
AB - Reports on 3 tribally sponsored rehabilitation programs which have matched their treatment philosophy and methods to the needs of this population. Emphasis is given to: (a) the involvement of the Indian in planning and in operating the programs, (b) the treatment philosophy, (c) the relationship of the courts to the programs, and (d) the need for uniform standards of evaluating patients. In a discussion, P. E. Ryberg generally endorses the approach and philosophy of the authors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rehabilitation programs
KW - self-involvement in planning & operation & treatment philosophy & relation of court & need for uniform evaluation standards
KW - American Indian alcoholics
KW - 1972
KW - Alcoholism
KW - Ethnology
KW - Evaluation
KW - Rehabilitation
KW - 1972
DO - 10.1176/ajp.128.11.1450
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1972-31841-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Richardson, J. A.;
AU - Borchardt, K. A.;
T1 - Antibacterial effect of different dialysates
CT - Antibacterial effect of different dialysates
JO - British Medical Journal (England)
JF - British Medical Journal (England)
Y1 - 1972/05/20/
VL - 2
IS - May 20
SP - 468
EP - 469
SN - 09598146
AD - U.S. Public Health Service Hospital, San Francisco, California
N1 - Accession Number: 9-3801; Language: English; References: 3; Publication Type: Letters; Journal Coden: BMJOAE; Section Heading: Drug Evaluations; Microbiology; Abstract Author: Joan Lentine
N2 - Dialysis solutions containing acetate were compared to lactate-containing solutions regarding their ability to confer protection against peritonitis in dogs. During peritoneal dialysis, introduction of each new batch of solution dilutes the substances which have diffused into the peritoneal space during the preceding exchange. The possibility remains that the greater antibacterial effect of acetate exists in the more dilute fluids immediately after each change of dialysate. This possibility was tested with 8 pairs of dialyses on six 20 kg. female dogs. For one dialysis of a pair, the solution contained 41 meq/1. of acetate, for the other, a like concentration of lactate. Results showed that the acetate solutions did not exert a greater antibacterial effect than the lactate solutions within the peritoneal space. The protective effect of the acetate solutions resides in their greater capacity to kill organisms inadvertently introduced into fluids during preparation or storage.
KW - Acetates--solutions--dialysis, peritoneal, protection, peritonitis, compared to lactate solutions, in dogs;
KW - Lactates--solutions--dialysis, peritoneal, protection, peritonitis, compared to acetate solutions, in dogs;
KW - Solutions--dialysis--peritoneal, protection, peritonitis, comparison of acetate to lactate, in dogs;
KW - Dialysis--peritoneal--solutions, protection, peritonitis, comparison of acetate to lactate, in dogs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=9-3801&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Baker, S. L., Jr.;
T1 - U.S. Army heroin abuse identification program in Vietnam: implications for a methadone program
CT - U.S. Army heroin abuse identification program in Vietnam: implications for a methadone program
JO - Am. J. Pub. Health
JF - Am. J. Pub. Health
Y1 - 1972/06/01/
VL - 62
IS - Jun
SP - 857
EP - 860
AD - Directorate of Professional Service, Office of the Surgeon General, Department of the Army, Washington, D.C. 20314
N1 - Accession Number: 10-1194; Language: English; Trade Name: Heroin; Generic Name: Diacetylmorphine; Chemical Name: Diacetylmorphine--561-27-3 Methadone--76-99-3; References: 7; Journal Coden: AJPEAG; Section Heading: Sociology, Economics and Ethics; Abstract Author: Diorita C. Fletcher
N2 - The program of the U.S. Army to identify heroin (diacetylmorphine) users in Vietnam as well as whether methadone can be used with servicemen is discussed. Opiate use among servicemen has become a serious problem in terms of the inherent epidemiological characteristics of the opiates, the rise in crimes relating to narcotics use, the harmful effects on the users' health, and the growing belief that medical/behavioral science treatment for the physiologically or psychologically drug-dependent individual is a nescessity. The U.S. Army drug abuse program is dedicated to preventive education, the early surfacing of those with drug-determined maladjustment and more effective rehabilitation of soldiers while on active duty. At this time, however, it has not found sufficient reason for initiating methadone maintenance programs in the Army.
KW - Diacetylmorphine--abuse-;
KW - Methadone--maintenance-;
KW - Dependence--diacetylmorphine--military, identification of users and applicability of methadone programs;
KW - Narcotics--diacetylmorphine--abuse, military, identification of users and applicability of methadone programs;
KW - Drug abuse--diacetylmorphine--military, identification of users and applicability of methadone programs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1194&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Horowitz, Herschel S.
AU - Heifetz, Stanley B.
T1 - The Effect of Partial Defluoridation of a Water Supply on Dental Fluorosis--Final Results in Bartlett, Texas, After 17 Years.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/06//
VL - 62
IS - 6
M3 - Article
SP - 767
EP - 769
PB - American Public Health Association
SN - 00900036
AB - In 1952, a defluoridation plant was installed in a small community in Texas to demonstrate an effective means of removing excess fluorides from drinking water. The results of a final survey made in 1969 showed that the prevalence of fluorosis was reduced dramatically by partial defluoridation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Water fluoridation
KW - Fluorides -- Physiological effect
KW - Drinking water
KW - Fluorosis
KW - Water supply
KW - Preventive dentistry
KW - Mottled enamel
KW - Health surveys
KW - Texas
N1 - Accession Number: 24294164; Horowitz, Herschel S. 1; Heifetz, Stanley B. 2; Affiliations: 1: Chief, Community Programs Section, Caries Prevention and Research Branch, National Institute of Dental Research, Public Health Service, U.S. Department of Health, Education and Welfare, Westwood Building, 4333 Westbard Ave., Bethesda, Maryland 20016; 2: Senior Investigator, Community Programs Section, Caries Prevention and Research Branch, National Institute of Dental Research, Public Health Service, U.S. Department of Health, Education and Welfare, Westwood Building, 4333 Westbard Ave., Bethesda, Maryland 20016; Issue Info: Jun1972, Vol. 62 Issue 6, p767; Thesaurus Term: Water fluoridation; Thesaurus Term: Fluorides -- Physiological effect; Thesaurus Term: Drinking water; Thesaurus Term: Fluorosis; Thesaurus Term: Water supply; Subject Term: Preventive dentistry; Subject Term: Mottled enamel; Subject Term: Health surveys; Subject: Texas; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Possible modifications of USP microbial limits and tests
CT - Possible modifications of USP microbial limits and tests
JO - Drug Cosmet. Ind.
JF - Drug Cosmet. Ind.
Y1 - 1972/06/01/
VL - 110
IS - Jun
SP - 32
EP - 21
AD - Drug Microbiology Branch, Food and Drug Administration Washington, D.C.
N1 - Accession Number: 10-0719; Language: English; References: 20; Journal Coden: DCINAQ; Section Heading: Microbiology; Pharmaceutical Technology; Abstract Author: Sheila L. Ross
N2 - This article presents a microbiological classification of pharmaceuticals, characterizes objectionable microorganisms for raw ingredients and classes of finished products, and suggests procedures to determine and enhance the microbiological quality of finished pharmaceutical products. Freedom from objectionable microbial contaminants should have a parity in drug compendial monographs as do tests for heavy metal contaminants. The epidemic of hospital septicemias from in-use contamination of parenteral solutions by environmental organisms points to the greater control that must be exerted by drug manufacturers over this aspect of drug quality. These topics were discussed in the context of current microbiological tests in \IT/U.S.P. XVIII\OK/ and possible modifications for \IT/U.S.P. XIX.\OK/
KW - Pharmacopeial standards--contamination--microbiological, possible modification of U.S.P. microbial limits and tests, discussion;
KW - Contamination--microbiological--pharmacopeial standards, possible modification of U.S.P. microbial limits and tests, discussion;
KW - Tests--microbiological--contamination, possible modification of U.S.P. microbial limits and tests, discussion;
KW - United States Pharmacopeia--tests--microbiological, possible modifications, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-0719&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hopkins, H. C.;
T1 - Keeping the kick in antibiotics
CT - Keeping the kick in antibiotics
JO - FDA Pap.
JF - FDA Pap.
Y1 - 1972/06/01/
VL - 6
IS - Jun
SP - 14
EP - 17
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 10-1007; Language: English; Journal Coden: FDAPAL; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - Food and Drug Administration regulations and recommendations for restricting the use of antibiotics in animals to increase production are discussed.
KW - Antibiotics--veterinary--use, restrictions, regulations and recommendations, FDA;
KW - Drugs--veterinary--antibiotics, use, restrictions, regulations and recommendations, FDA;
KW - Food and Drug Administration (U.S.)--antibiotics--veterinary, use, restrictions, regulations and recommendations;
KW - Regulations--antibiotics--veterinary, use, restrictions, regulations and recommendations, FDA;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1007&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
AU - Tanner, J. T.;
T1 - Determination of mercury in pharmaceutical products by neutron activation analysis
CT - Determination of mercury in pharmaceutical products by neutron activation analysis
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/06/01/
VL - 61
IS - Jun
SP - 936
EP - 938
SN - 00223549
AD - National Center for Antibiotic Analysis and the Division of Food Chemistry and Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-4699; Language: English; Chemical Name: Mercury--7439-97-6; References: 11; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Suppositories, solutions and bulk powders containing mercury compounds were analyzed by neutron activation analysis.
KW - Mercury--activation analysis-;
KW - Activation analysis--mercury--in pharmaceutical products;
KW - Suppositories--mercury--activation analysis;
KW - Solutions--mercury--activation analysis;
KW - Powders--mercury--activation analysis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4699&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1973-27116-001
AN - 1973-27116-001
AU - Shore, James H.
T1 - Suicide and suicide attempts among American Indians of the Pacific Northwest.
JF - International Journal of Social Psychiatry
JO - International Journal of Social Psychiatry
JA - Int J Soc Psychiatry
Y1 - 1972///Sum 1972
VL - 18
IS - 2
SP - 91
EP - 96
CY - US
PB - Sage Publications
SN - 0020-7640
SN - 1741-2854
N1 - Accession Number: 1973-27116-001. PMID: 4650924 Partial author list: First Author & Affiliation: Shore, James H.; Indian Health Service, Portland, Ore. Release Date: 19731001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Attempted Suicide; Sex Linked Developmental Differences; Suicide. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 6. Issue Publication Date: Sum 1972.
AB - Presents a survey of characteristics of suicides and suicide attempts in 1969 on Indian reservations in Washington, Oregon, and Idaho. A completed suicide rate of 28/100,000 was reported, with 16 times more attempts than completions. Attempts tended to be made by young women, using drugs. Completed suicides tended to be made by men in their 30's, using firearms or hanging. Students at an Indian boarding school showed an exceptionally high rate of attempts (3,488/100,000) in comparison to the attempt rate on the reservation (462/100,000). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide & suicide attempts on Indian reservations in Washington & Oregon & Idaho
KW - male vs. female Indians
KW - 1972
KW - American Indians
KW - Attempted Suicide
KW - Sex Linked Developmental Differences
KW - Suicide
KW - 1972
DO - 10.1177/002076407201800202
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1973-27116-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Steinfeld, J.;
T1 - Attitude of medicine toward the pharmacist's expanding role
CT - Attitude of medicine toward the pharmacist's expanding role
JO - Am. J. Pharm.
JF - Am. J. Pharm.
Y1 - 1972/07/01/
VL - 144
IS - Jul/Aug
SP - 116
EP - 121
AD - U. S. Public Health Service, Department of Health, Education, and Welfare, Washington, D.C. 20201
N1 - Accession Number: 10-4646; Language: English; Journal Coden: AJPRAL; Section Heading: Pharmacy Practice
KW - Physicians--attitudes--towards pharmacists expanding roles;
KW - Pharmacists--role--physicians attitudes to expanding responsibilities;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4646&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Plato, C.;
T1 - Differential scanning calorimetry as a general method for determining purity and heat of fusion of high purity organic chemicals: application to 64 compounds
CT - Differential scanning calorimetry as a general method for determining purity and heat of fusion of high purity organic chemicals: application to 64 compounds
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1972/07/01/
VL - 44
IS - Jul
SP - 1531
EP - 1534
AD - Division of Chemical Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-1134; Language: English; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry; Drug Analysis
KW - Chemicals--organic--calorimetry, differential scanning, to determine purity and heat of fusion;
KW - Calorimetry--differential scanning--to determine purity and heat of fusion of high purity organic chemicals;
KW - Purity--chemicals--organic, determination, using differential scanning calorimetry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1134&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zacherle, B. J.;
AU - Richardson, J. A.;
T1 - Irreversible renal failure secondary to hypertension induced by oral contraceptives
CT - Irreversible renal failure secondary to hypertension induced by oral contraceptives
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1972/07/01/
VL - 77
IS - Jul
SP - 83
EP - 85
SN - 00034819
AD - U.S. Public Health Service Hospital, San Francisco, California
N1 - Accession Number: 10-0217; Language: English; References: 14; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - Oral contraceptive therapy was responsible for 2 episodes of severe hypertension in a young woman. On the second occasion she developed malignant arteriolar nephrosclerosis that progressed to end-stage renal failure before the contraceptive therapy was stopped. She is now well, requiring no antihypertensive medications, after maintenance hemodialysis, bilateral nephrectomy, and kidney transplantation. The implications of this rare but not unexpected complication from the casual use of hormonal contraceptives are discussed.
KW - Contraceptives, oral--adverse reactions--irreversible renal failure secondary to hypertension, in human;
KW - Drugs, adverse reactions--contraceptives, oral--irreversible renal failure secondary to hypertension, in human;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-0217&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cooper, J. F.;
AU - Hochstein, H. D.;
AU - Seligmann, E. B., Jr.;
T1 - Limulus test for endotoxin (pyrogen) in radiopharmaceuticals and biologicals
CT - Limulus test for endotoxin (pyrogen) in radiopharmaceuticals and biologicals
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1972/07/01/
VL - 26
IS - Jul-Aug
SP - 153
EP - 162
AD - Bureau of Radiological Health, United States Public Health Service, 12720 Twinbrook Parkway, Rockville, Maryland 20852
N1 - Accession Number: 10-0816; Language: English; References: 16; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - A cell lysate prepared from amebocytes of Limulus polyphemus is a sensitive reagent for detection of bacterial endotoxin (pyrogen). The production of amebocyte lysate and the preparation of an in vitro test system utilizing buffered, lyophilized lysate is described. This test detects pyrogenic concentrations of purified pyrogen within one hour. In testing 155 radiopharmaceuticals and biological products for pyrogen by the rabbit and Limulus methods, 130 results were in agreement. Two of 29 positive pyrogen tests were not detected in vitro; 24 tests were positive only in vitro. Preliminary results indicated that the Limulus test is a rapid, sensitive, and reproducible method for detecting pyrogen in these products.
KW - Tests--pyrogens--endotoxins, detection in radiopharmaceuticals and biologicals by in vitro Limulus test;
KW - Pyrogens--endotoxins--detection, in radiopharmaceuticals and biologicals, by in vitro Limulus test;
KW - Radiopharmaceuticals--and biologicals--endotoxins, detection by in vitro Limulus test;
KW - Endotoxins--tests--detection, in radiopharmaceuticals and biologicals, by in vitro Limulus test;
KW - Contamination--endotoxins--detection, in radiopharmaceuticals and biologicals, by in vitro Limulus test;
KW - Bacteria--endotoxins--detection, in radiopharmaceuticals and biologicals, by in vitro Limulus test;
KW - Biologicals--and radiopharmaceuticals--endotoxins, detection by in vitro Limulus test;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-0816&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Peters, C. J.
AU - Johnson, K. M.
T1 - SERUM IMMUNOGLOBULIN LEVELS IN AUSTRALIA ANTIGEN POSITIVE AND AUSTRALIA ANTIGEN NEGATIVE HEPATITIS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/07//
VL - 11
IS - 3
M3 - Article
SP - 381
EP - 391
SN - 00099104
AB - Ig levels were determined by radial immunodiffusion in uncomplicated cases of acute hepatitis with or without Australia antigenaemia. Initial sera from Australia antigen negative cases showed a striking elevation in IgM levels when compared to Australia antigen positive cases (6.5 versus 1.9 mg/ml). None of twenty-four Australia antigen positive cases exceeded 3 mg/ml IgM, and only 3/58 Australia antigen negative cases exhibited values below 3 mg/ml. initial sera from Australia antigen positive and Australia antigen negative subjects did not differ in concentration of IgG, IgA, or IgD. Serial determinations of IgG revealed a transient fall in patients with Australia antigen positive hepatitis, and a rise in Australia antigen negative cases. Asymptomatic, Australia antigen positive, Guaymi Indian subjects were compared to matched Australia antigen negative controls from the same indigenous group and no differences in the concentration of IgG, IgM, IgA or IgD were found, although elevations of IgG and IgM were common in both groups. No evidence of abnormal proteins was found when sera were tested by cellulose acetate electrophoresis or by immunoelectrophoresis versus immunoglobulin-specific anti- sera. Ultracentrifugal analysis failed to detect `7S' IgM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNODIFFUSION
KW - ANTIGENS
KW - IMMUNOGLOBULIN G
KW - ANTIGEN-antibody reactions
KW - IMMUNOELECTROPHORESIS
KW - ELECTROPHORESIS
N1 - Accession Number: 14545001; Peters, C. J. 1; Johnson, K. M. 1; Source Information: Jul72, Vol. 11 Issue 3, p381; Subject: IMMUNODIFFUSION; Subject: ANTIGENS; Subject: IMMUNOGLOBULIN G; Subject: ANTIGEN-antibody reactions; Subject: IMMUNOELECTROPHORESIS; Subject: ELECTROPHORESIS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Eye products: handle with care
CT - Eye products: handle with care
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1972/07/01/
VL - 6
IS - Jul-Aug
SP - 5
EP - 7
SN - 03621332
AD - Food and Drug Administration, Drug Microbiology Branch, Bureau of Drugs, 5600 Fishers Lane, Rockville, Maryland
N1 - Accession Number: 10-2319; Language: English; Journal Coden: FDACBH; Human Indicator: Yes; Section Heading: Microbiology; Pharmacy PracticePharmaceutical Technology; Abstract Author: James B. Lumbard
N2 - The risk of infection from contaminated eye products, both drug and cosmetic, is discussed. The presence of Pseudomonas species and other hazardous micro-organisms in eye make-up is a problem of which every consumer should be aware. Several case presentations of infections are presented. Several precautions are presented to the consumer to keep in mind when using eye cosmetics.
KW - Ophthalmic preparations--contamination--drugs, and cosmetics, discussion;
KW - Contamination--microbiological--ophthalmic preparations, drugs, and cosmetics, discussion;
KW - Cosmetics--ophthalmic preparations--contamination, discussion;
KW - Formulations--ophthalmic preparations--drugs, and cosmetics, contamination, discussion;
KW - Sterility--ophthalmic preparations--drugs, and cosmetic, contamination, discussion;
KW - Pseudomonas aeruginosa--ophthalmic preparations--contamination, drug and cosmetic, cases, discussion;
KW - Toxicity--Pseudomonas aeruginosa--ophthalmic preparations, contamination, drug and cosmetic, cases, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2319&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
T1 - Immune Response in the Turtle (Chrysemys picta ).
JO - Immunology
JF - Immunology
Y1 - 1972/07//
VL - 23
IS - 1
M3 - Article
SP - 45
EP - 52
SN - 00192805
AB - The immune response of painted turtles (Chrysemys picta) to four purified protein antigens was evaluated by radioimmunoelectrophoresis. Specific antibody production was consistently detected and antigen binding was related to four immunoglobulin (Ig) precipitin lines (called Igl, 2, 3, 4) in turtle serum. Antibody activity was detected first in the Ig1 or Ig2 and then later in the course of immunization in Ig3 and Ig4. Igl was about 19S in size, was not detectable after reduction and alkylation, and was the only Ig absent from turtle lymph. Ig3 and Ig4 were about 7S in size and Ig2 appeared slightly heavier by sucrose density gradient and Sephadex G-200 analysis. Haemagglutinins produced after primary inoculation were routinely sensitive to mild reduction and alkylation although antigen-binding capacity was still detectable. However, mercaptoethanol-resistant haemagglutinins were found in sera from turtles after booster injections of antigen. The electrophoretically slowest gamma globulin in turtle serum did not develop specific antigen binding capacity, but did bind Fe59 and presumably represents a transferrin-like protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - IMMUNOLOGY
KW - CHRYSEMYS
KW - TURTLES
KW - ANTIGEN-antibody reactions
KW - IMMUNOGLOBULINS
KW - HEMAGGLUTININ
N1 - Accession Number: 13378221; Coe, J.E. 1; Source Information: Jul72, Vol. 23 Issue 1, p45; Subject: IMMUNE response; Subject: IMMUNOLOGY; Subject: CHRYSEMYS; Subject: TURTLES; Subject: ANTIGEN-antibody reactions; Subject: IMMUNOGLOBULINS; Subject: HEMAGGLUTININ; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jaqueline J.
AU - Houston, Robert
T1 - A comparison of the effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/07//
VL - 80
IS - 4
M3 - Article
SP - 267
EP - 271
SN - 0029845X
AB - The effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque was studied in 182 college students. At an initial screening examination, plaque was assessed using the gingival index. These plaque scores were used to divide the group into those with poor and those with good oral cleanliness. Within each of the two groups, the subjects were randomly assigned to a toothbrushing method and to one of three instructors. Then the participants had their teeth cleaned and were asked to abstain from toothbrushing for one week. After this period of plaque accumulation the participants were again scored for plaque. The test subjects were carefully instructed in the particular tooth-brushing method they were to use and the controls were asked to resume their usual methods. One week later the participants were again examined for plaque. An interaction between toothbrushing method and instructor was found indicating that the effectiveness of a particular method depended in pan on. the instructor. Nevertheless, the CHARTERS' and scrub methods of brushing appeared to be more effective in removing plaque. Generally, subjects with cleaner teeth prior to the stu achieved grater plaque reductions than those with initially poor oral cleanliness. All methods of bruching were relatively ineffective in removing proximal plaque. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOOTHBRUSHES
KW - DENTAL plaque
KW - ORAL hygiene products
KW - DENTAL deposits
KW - GINGIVAL fluid
KW - DENTAL care
N1 - Accession Number: 13235069; Frandsen, Asger M. 1; Barbano, Joseph P. 2; Suomi, John D. 2; Chang, Jaqueline J. 2; Houston, Robert 3; Source Information: 1972, Vol. 80 Issue 4, p267; Subject: TOOTHBRUSHES; Subject: DENTAL plaque; Subject: ORAL hygiene products; Subject: DENTAL deposits; Subject: GINGIVAL fluid; Subject: DENTAL care; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1973-24207-001
AN - 1973-24207-001
AU - Scheib, B. Thomas
AU - Sharf, Donald J.
T1 - Response latency differences in speech shadowing as an indicator of distinctive features of consonants.
JF - Language and Speech
JO - Language and Speech
JA - Lang Speech
Y1 - 1972/07//
VL - 15
IS - 3
SP - 270
EP - 278
CY - United Kingdom
PB - Kingston Press
SN - 0023-8309
SN - 1756-6053
N1 - Accession Number: 1973-24207-001. PMID: 4656370 Partial author list: First Author & Affiliation: Scheib, B. Thomas; Public Health Service, Bureau of Occupational Safety & Health, Cincinnati, O. Other Publishers: Sage Publications. Release Date: 19730901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consonants; Graduate Students; Response Latency; Speech Characteristics; Speech Perception. Classification: Human Experimental Psychology (2300). Population: Human (10). Page Count: 9. Issue Publication Date: Jul, 1972.
AB - Investigated articulatory features which are important to perception in a study with 15 experienced graduate students. Ss shadowed a recording of consonant-vowel syllables orally and by means of a hand-held switch. Vocal shadowing was tape-recorded and the onsets of the stimuli and manual responses were recorded on a polygraph. Oral responses indicated perceptual confusions and manual responses measured the shadowing latency for each consonant. After eliminating the dental fricatives because of perceptual confusions, the remaining consonants (e.g., p, b, t, d, k) were classified according to a feature system and latency scores analyzed. Analysis of variance indicated significant differences among sounds arranged according to features. A post hoc comparison among all possible features (interrupted, grave, acute, diffuse, strident, voiced, tense, nasal) showed that 3 features were primarily responsible for the significant variance: stridency, voicing, and nasalization. Results do not seem to support the concept of a hierarchy of features which order the decisions made in consonant identification. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - response latency differences in speech shadowing
KW - indication of distinctive features of consonants
KW - experienced graduate students
KW - 1972
KW - Consonants
KW - Graduate Students
KW - Response Latency
KW - Speech Characteristics
KW - Speech Perception
KW - 1972
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Gowdy, J. M.;
T1 - Feminine deodorant sprays
CT - Feminine deodorant sprays
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1972/07/27/
VL - 287
IS - Jul 27
SP - 203
SN - 00284793
AD - Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 9-3747; Language: English; References: 4; Publication Type: Letters; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Adverse Drug Reactions; Abstract Author: Joan Lentine
N2 - Twenty-six cases of injury from the use of feminine deodorant sprays reported to the FDA are discussed. Although injuries were not life-threatening, all were locally severe, and average recovery time was 30 days. The particular offending ingredient of the sprays could not be identified.
KW - Aerosols--feminine hygiene--adverse reactions, case reports;
KW - Drugs, adverse reactions--aerosols--feminine hygiene, case reports;
KW - Food and Drug Administration (U.S.)--aerosols--feminine hygiene, adverse reactions, case reports;
KW - Toxicity--aerosols--feminine hygiene, case reports;
KW - Deodorants--feminine hygiene--adverse reactions, case reports;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - King, B. G.;
AU - Schaplowsky, A. F.;
AU - McCabe, E. B.;
T1 - Occupational health and child lead poisoning: mutual interests and special problems
CT - Occupational health and child lead poisoning: mutual interests and special problems
JO - Am. J. Pub. Health
JF - Am. J. Pub. Health
Y1 - 1972/08/01/
VL - 62
IS - Aug
SP - 1056
EP - 1059
AD - Public Health Service, Division of Community Injury Control, Bureau of Community Environmental Management, Cincinnati, Ohio 45202
N1 - Accession Number: 10-2656; Language: English; Chemical Name: Lead--7439-92-1; References: 22; Journal Coden: AJPEAG; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Paul E. Groth
N2 - Lead poisoning among children and among workers is discussed in terms of the similarities and differences of these overlapping problems.
KW - Lead--poisoning-;
KW - Poisoning--lead--pediatrics, and industrial, similarities and differences;
KW - Toxicity--lead--poisoning, pediatrics, and industrial, similarities and differences;
KW - Toxicity, environmental--lead--poisoning, pediatrics, and industrial, similarities and differences;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Cassidy, James E.
AU - Barnes, George P.
T1 - Organization and Operation of a Military Preventive Dentistry Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/08//
VL - 62
IS - 8
M3 - Article
SP - 1072
EP - 1076
PB - American Public Health Association
SN - 00900036
AB - A description is presented of the organization and operation of a preventive dentistry program at a large Army post. Three major areas of preventive dentistry are emphasized, treatment, education and motivation, and research. Relation to community programs and private practice are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Water fluoridation
KW - Fluorides
KW - Preventive dentistry
KW - Military bases
KW - Dental health education
KW - Dental public health
KW - Dental care
KW - Military personnel
KW - Dentistry
KW - Dental prophylaxis
N1 - Accession Number: 24294233; Cassidy, James E. 1; Barnes, George P. 2; Affiliations: 1: , Dental Corps, U.S. Army, and Chief, Professional Branch, Office of the Assistant for Dental Services, Office of the Surgeon General, Department of the Army; 2: Lieutenant Colonel, Dental Corps, U.S. Army and Assistant Chief, Preventive Dentistry Division, U.S. Army Institute of Dental Research, U.S. Army Medical Research and Development Command, Walter Reed Army Medical Center; Issue Info: Aug1972, Vol. 62 Issue 8, p1072; Thesaurus Term: Water fluoridation; Thesaurus Term: Fluorides; Subject Term: Preventive dentistry; Subject Term: Military bases; Subject Term: Dental health education; Subject Term: Dental public health; Subject Term: Dental care; Subject Term: Military personnel; Subject Term: Dentistry; Subject Term: Dental prophylaxis; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 928110 National Security; NAICS/Industry Codes: 911110 Defence services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Capell, P. T.;
AU - Paulsen, C. A.;
T1 - Effect of exogenous testosterone upon serum FSH and LH concentrations in normal males
CT - Effect of exogenous testosterone upon serum FSH and LH concentrations in normal males
JO - Contraception (USA)
JF - Contraception (USA)
Y1 - 1972/08/01/
VL - 6
IS - Aug
SP - 135
EP - 143
SN - 00107824
AD - Department of Medicine, University of Washington and the Division of Endocrinology, United States Public Health Service Hospital, Seattle, Washington
N1 - Accession Number: 10-3530; Language: English; Chemical Name: Testosterone--58-22-0; References: 16; Journal Coden: CCPTAY; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Tom Garrison
N2 - Testosterone propionate, 100 mg., was administered I.M. daily for 4 days to 4 normal males; serum samples for FSH and LH determinations were collected from each subject daily before, during and for 4 days following the injections. As anticipated, serum LH levels promptly dropped to undetectable levels. Serum FSH levels dropped significantly to 60-70% of baseline values in all 4 subjects. These results suggest that testosterone may have some part in the control of serum FSH as well as LH levels in normal males.
KW - Testosterone--propionate-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Fluorometric determination of ethinyl estradiol in tablets
CT - Fluorometric determination of ethinyl estradiol in tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/08/01/
VL - 61
IS - Aug
SP - 1306
EP - 1308
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Los Angeles, California 90015
N1 - Accession Number: 12-0452; Language: English; Chemical Name: Ethinyl estradiol--57-63-6; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Ethinyl estradiol--fluorometry-;
KW - Tablets--ethinyl estradiol--fluorometry;
KW - Fluorometry--ethinyl estradiol--tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Goldwitz, B. A.;
T1 - Determination of pentylenetetrazol in tablets and injectables by NMR
CT - Determination of pentylenetetrazol in tablets and injectables by NMR
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/08/01/
VL - 61
IS - Aug
SP - 1309
EP - 1310
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 12-0450; Language: English; Chemical Name: Pentylenetetrazol--54-95-5; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Pentylenetetrazol--spectrometry, nuclear magnetic resonance-;
KW - Tablets--pentylenetetrazol--and injections, NMR spectrometry;
KW - Injections--pentylenetetrazol--and tablets, NMR spectrometry;
KW - Central nervous system stimulants--pentylenetetrazol--spectrometry, nuclear magnetic resonance, tablet and injections;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lockhart, J. D.;
T1 - How toxic is hexachlorophene?
CT - How toxic is hexachlorophene?
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1972/08/01/
VL - 50
IS - Aug
SP - 229
EP - 235
SN - 00314005
AD - Division of Anti-Infective Drug Products, Office of Scientific Evaluation, Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 10-1955; Language: English; Chemical Name: Hexachlorophene--70-30-4; Therapeutic Class: (38:00); AHFS Class: Disinfectants hexachlorophene; References: 21; Journal Coden: PEDIAU; Section Heading: Toxicity; Abstract Author: Brenda Sue Martinez
N2 - Animal studies, human adverse effect reports, and human adsorption studies related to the toxicity of hexachlorophene were discussed. As a result of these published and unpublished studies, in January, 1972, the FDA proposed the following to limit consumer exposure to hexachlorophene: (1) that hexachlorophene be excluded from cosmetics except as part of a preservative system, in levels not to exceed 0.1%; (2) that when hexachlorophene is a component of drugs, such drugs must have approved new drug applications and must bear a caution label to indicate that they contain hexachlorophene; and (3) when the hexachlorophene content of drugs exceeds 0.75%, such drugs must bear the prescription label.
KW - Hexachlorophene--toxicity-;
KW - Disinfectants--hexachlorophene--toxicity, FDA viewpoint, discussion;
KW - Toxicity--hexachlorophene--viewpoints, FDA;
KW - Labeling--hexachlorophene--regulations, FDA;
KW - Regulations--hexachlorophene--labeling, FDA;
KW - Food and Drug Administration (U.S.)--hexachlorophene--toxicity, viewpoints;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gowdy, J. M.;
T1 - Stramonium intoxication: review of symptomatology in 212 cases
CT - Stramonium intoxication: review of symptomatology in 212 cases
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/08/07/
VL - 221
IS - Aug 7
SP - 585
EP - 587
AD - Food and Drug Administration, U. S. Department of Health, Education, and Welfare, Washington, D. C.) (reprints: P.O. Box 31, Falls Church, Virginia 22046
N1 - Accession Number: 9-4335; Language: English; Chemical Name: Stramonium--8063-18-1; Therapeutic Class: (12:08.08); AHFS Class: Spasmolytics stramonium; References: 23; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Sociology, Economics and Ethics; Abstract Author: Joan Lentine
N2 - A report on the abuse of stramonium-containing asthma powders is presented. These powders, designed to be burned and inhaled, produce hallucinations when taken by mouth. A typical asthma preparation contains 50% stramonium, 25% potassium nitrate to facilitate burning, belladonna, grindelia, or tobacco to make the desired bulk, along with trace amounts of flavoring agents. The alkaloids of stramonium are the same as those of belladonna: scopolamine and atropine in varying proportions depending on species and conditions of cultivation, harvesting, and storage. The mixture is adjusted to an alkaloid content of 0.3%, the equivalent of 1.25 mg. of atropine per unit dosage, e.g., per cigarette, pipeful, etc. About 0.01% of the available alkaloid is absorbed systemically when the product is used as directed. In general, the toxic effects of stramonium are extensions of the therapeutic actions of the belladonna alkaloids. Dryness of the mouth appears first, at around the 0.5 mg. level. With a dosage equivalent to 1 mg. of atropine, pupillary dilation appears. A dose between 3 and 5 mg. produces intoxication, marked pupillary changes, visual disturbance, flushing, palpitation, and tachycardia. In addition to increasing progression of the above symptoms, higher doses produce delirium and fever. Depression, which may progress to coma, and cardiac and respiratory arrest are seen in the later stages of overdosage. The powders have been used in a one teaspoon dose for abuse. To produce visions, from 1 to 3 teaspoonsful are dissolved in a cola drink, beer, or other beverage or swallowed in capsules. Hallucinations occur in about 50% of the users; delirium and serious toxic symptoms are seen in only 25% of the users. Five deaths are known to have occurred due to impairment of judgement and physical coordination from the effects of stramonium-containing asthma powders. Therapeutic measures for treating stramonium abusers are discussed.
KW - Stramonium--powders-;
KW - Powders--stramonium--asthma, abuse, ingestion, in humans;
KW - Drug abuse--stramonium--powders, asthma, ingestion, in humans;
KW - Spasmolytics--stramonium--powders, asthma, ingestion, in humans;
KW - Hallucinogens--stramonium--powders, asthma, ingestion, in humans;
KW - Asthma--powders--containing stramonium, abuse, ingestion, in humans;
KW - Alkaloids--stramonium--abuse, asthma powders, ingestion, in humans;
KW - Toxicity--stramonium--abuse, ingestion of asthma powders, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fortner, C. L.;
T1 - Reduction in serum CO\IF/2\BS/ during hyperalimentation
CT - Reduction in serum CO\IF/2\BS/ during hyperalimentation
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/08/14/
VL - 221
IS - Aug 14
SP - 716
AD - Public Health Service Hospital, Baltimore, Maryland
N1 - Accession Number: 10-0299; Language: English; References: 1; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Biopharmaceutics; Drug EvaluationsPharmacology; Abstract Author: Joan Lentine
N2 - Adjusting the pH of hyperalimentation solutions to 7.0 has kept the serum carbon dioxide content of patients from falling. Study results of a patient are presented in a table.
KW - Hydrogen ion concentration--hyperalimentation--injections, effects, on serum CO\IF/2\BS/ content, in patients;
KW - Hyperalimentation--injections--effects, of pH, on serum CO\IF/2\BS/ content, in patients;
KW - Injections--hyperalimentation--effects, of pH, on serum CO\IF/2\BS/ content, in patients;
KW - Caloric agents--hyperalimentation--injections, effects, of pH, on serum CO\IF/2\BS/ content, in patients;
KW - Nutrition--hyperalimentation--injections, effects, of pH, on serum CO\IF/2\BS/ content, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Evans, J. R.;
AU - Gilden, M. M.;
AU - Bruch, C. W.;
T1 - Methods for isolating and identifying objectionable gram negative bacteria and endotoxins from topical products
CT - Methods for isolating and identifying objectionable gram negative bacteria and endotoxins from topical products
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1972/08/17/
VL - 23
IS - Aug 17
SP - 549
EP - 564
SN - 00379832
AD - Drug Microbiology Branch, Division of Drug Biology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-0958; Language: English; References: 29; Journal Coden: JSCCA5; Section Heading: Methodology; Microbiology; Abstract Author: Douglas L. Thompson
N2 - The use of hyperimmune typing sera, pyocine typing, endotoxin determinations, and animal pathogenicity studies for identifying bacterial contaminants in drug and cosmetic topical preparations is discussed.
KW - Contamination--microbiological--topical preparations, isolation and identification methods;
KW - Methodology--contamination--microbiological, isolation and identification methods;
KW - Bacteria--gram negative--contamination, topical preparations, methods of isolation and identification;
KW - Tests--contamination--microbiological, topical preparations, discussion;
KW - Topical preparations--contamination--microbiological, methods for isolating and identifying gram negative bacteria;
KW - Cosmetics--contamination--microbiological, methods of isolation and identification;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - COLE, WILLIAM S.
T1 - Chest X-rays.
JO - Science
JF - Science
Y1 - 1972/08/18/
VL - 177
IS - 4049
M3 - Article
SP - 563
EP - 563
SN - 00368075
N1 - Accession Number: 85116840; COLE, WILLIAM S. 1; Affiliations: 1: Bureau of Radiological Health, Food and Drug Administration, Department of Health, Education, and Welfare, Rockville, Maryland 20852; Issue Info: 8/18/1972, Vol. 177 Issue 4049, p563; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Forbes, Allan L.
T1 - The Role of the Food and Drug Administration in the Nutritional Quality of Foods.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/09//
VL - 62
IS - 9
M3 - Article
SP - 1207
EP - 1209
PB - American Public Health Association
SN - 00900036
AB - A review is offered of the function of the Food and Drug Administration in relation to foods and of various activities and programs now being carried on. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Food supply
KW - Food -- Government policy
KW - Government programs
KW - Food -- Quality
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 24294267; Forbes, Allan L. 1; Affiliations: 1: Deputy Director, Division of Nutrition, Bureau of Foods, Food and Drug Administration, Washington, D.C.; Issue Info: Sep1972, Vol. 62 Issue 9, p1207; Thesaurus Term: Nutrition; Thesaurus Term: Food supply; Subject Term: Food -- Government policy; Subject Term: Government programs; Subject Term: Food -- Quality; Subject: United States ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Brooks, J. B.;
AU - Alley, C. C.;
AU - Jones, R.;
T1 - Reaction of nitrosamine with fluorinated anhydrides and pyridine to form electron capturing derivatives
CT - Reaction of nitrosamine with fluorinated anhydrides and pyridine to form electron capturing derivatives
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1972/09/01/
VL - 44
IS - Sep
SP - 1881
EP - 1884
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333
N1 - Accession Number: 9-4523; Language: English; Journal Coden: ANCHAM; Section Heading: Drug Analysis
KW - Nitrosamine--analysis-;
KW - Carcinogens--nitrosamine--chromatography, gas, by reaction with fluorinated anhydrides and pyridine to form electron capturing derivatives;
KW - Analysis--nitrosamine--chromatography, gas, by reaction with fluorinated anhydrides and pyridine to form electron capturing derivatives;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Anon.;
T1 - National Clearinghouse for Poison Control Centers: tabulations of 1971 reports
CT - National Clearinghouse for Poison Control Centers: tabulations of 1971 reports
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1972/09/01/
VL - Pages
IS - Sep-Oct
SP - 1
EP - 9
AD - Food and Drug Administration, Bureau of Product Safety, 5401 Westbard Avenue, Bethesda, Maryland 20016
N1 - Accession Number: 11-0029; Language: English; Chemical Name: Aspirin--50-78-2; Journal Coden: NCPBBY; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2 - Statistical data from 136,051 reports of ingestions from 505 poison control centers are presented. Aspirin poisonings have dropped from a high of 25.8% in 1965 to 10.1% in 1971. Such things as soaps, detergents, cleaners, plants, antihistamines and cold medications are being more frequently ingested by children under 5 years of age.
KW - Aspirin--poisoning-;
KW - Poisoning--statistics--United States, 1971;
KW - Statistics--poisoning--United States, 1971;
KW - Toxicity--poisons--statistics, United States, 1971;
KW - Pediatrics--poisoning--statistics, 1971, including aspirin;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0029&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gibson, M. R.;
AU - Lott, R. S.;
T1 - Suicide and the role of the pharmacist
CT - Suicide and the role of the pharmacist
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1972/09/01/
VL - NS12
IS - Sep
SP - 457
EP - 466
AD - U.S. Public Health Service, Bureau of Health Manpower, Div. of Physician and Health Professions Education, Bethesda, Maryland 20014
N1 - Accession Number: 12-3354; Language: English; References: 35; Journal Coden: JPHAA3; Section Heading: Pharmacy Practice; Abstract Author: Drucella Andersen
N2 - Pharmacists should be able to give advice on the drug aspects of suicide and should be aware of the activities of the local suicide prevention centers, psychiatric clinics, family counselors, marriage counselors and public health facilities so that they can refer patients who need such advisory personnel. Suicide from analgesic and soporific drugs is the third major method used. Barbiturates emerge as the most common cause of drug suicide.
KW - Pharmacists--information--suicides, role;
KW - Suicides--information--role, pharmacists;
KW - Information--suicides--role, pharmacists;
KW - Community service--suicides--information, pharmacist's role;
KW - Patient information--consultation--suicides, pharmacist's role;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3354&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chen, J.-Y. T.;
AU - Gould, J. H.;
T1 - Infrared studies of cyclohexylamine
CT - Infrared studies of cyclohexylamine
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1006
EP - 1014
AD - Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3956; Language: English; References: 17; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - The physical and chemical properties of cyclohexylamine were studied using IR spectrometry. The existence and dynamic equilibrium of conformers in cyclohexylamine in its physical states of solid, liquid and vapor were investigated.
KW - Cyclohecylamine--spectrometry, infrared-;
KW - Cyclamates--cyclohexylamine--spectrometry, infrared;
KW - Spectrometry, infrared--cyclohexylamine--cyclamates;
KW - Stability--cyclohexylamine--spectrometry, infrared;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3956&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chen, J.-Y. T.;
T1 - Infrared studies of dicyclohexylamine
CT - Infrared studies of dicyclohexylamine
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1015
EP - 1023
AD - Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3957; Language: English; References: 13; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - Physical and chemical properties of dicyclohexylamine were investigated by IR spectrometry. Characteristic IR absorption frequency of dicyclohexylamine derivatives are included.
KW - Dicyclohexylamine--spectrometry, infrared-;
KW - Cyclamates--dicyclohexylamine--spectrometry, infrared, and derivatives;
KW - Spectrometry, infrared--dicyclohexylamine--and derivatives;
KW - Stability--dicyclohexylamine--properties, physical and chemical, IR spectrometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3957&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Carson, N. A.;
T1 - Assay of NF ethylene by gas chromatography
CT - Assay of NF ethylene by gas chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1067
EP - 1069
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 10-3727; Language: English; Chemical Name: Ethylene--74-85-1; Therapeutic Class: (28:04); AHFS Class: Anesthetics ethylene; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Ethylene--chromatography, gas-;
KW - Chromatography, gas--ethylene--method, description;
KW - Anesthetics--ethylene--chromatography, gas, method, description;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3727&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Allen, R. G.;
T1 - Modification of present procedures for the determination of conjugated estrogens (equine) in various low-dosage forms
CT - Modification of present procedures for the determination of conjugated estrogens (equine) in various low-dosage forms
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1070
EP - 1073
AD - Food and Drug Administration, 599 Delaware Avenue, Buffalo, New York 14202
N1 - Accession Number: 10-3731; Language: English; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The presently used procedures for the colorimetric determination of conjugated estrogens (equine) have been modified for the assay of tablets, capsules, liquids, and creams of low declaration per dosage unit. Modifications in sample chromatographic column preparation and elution have provided a more efficient extraction of the steroids.
KW - Estrogenic substances--conjugated--chromatography, column and colorimetry;
KW - Chromatography, column--estrogenic substances--conjugated, and colorimetry;
KW - Colorimetry--estrogenic substances--conjugated, and column chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3731&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ballbach, R. L.;
AU - Beavin, P., Jr.;
AU - Walters, S. M.;
T1 - Study of testing methods for the detection of defects in disposable latex and plastic gloves
CT - Study of testing methods for the detection of defects in disposable latex and plastic gloves
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1074
EP - 1080
AD - Food and Drug Administration, 1560 East Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 10-4446; Language: English; Chemical Name: Latex--0; References: 9; Journal Coden: JANCA2; Section Heading: Pharmaceutical Technology
N2 - Several testing methods for the detection of holes in disposable gloves intended for medical use were investigated. An air inflation method was developed which proved to be the most sensitive and reliable. A survey of the quality of commercially available disposable latex and plastic gloves was conducted in which the air inflation method was compared with the pinhole testing procedure prescribed in the Department of Defense specifications for disposable gloves. The air inflation method gave more reliable results.
KW - Latex--gloves-;
KW - Control, quality--gloves--disposable, latex and plastic, test methods;
KW - Tests--gloves--disposable, latex and plastic, test methods;
KW - Plastics--gloves--disposable, detection of defects, test methods;
KW - Surgical supplies--gloves--disposable, latex and plastic, test methods for detecting defects;
KW - Toxicity, environmental--gloves--disposable, latex and plastic, detection of defects, test methods;
KW - Gloves--surgical--disposable, latex and plastic, test methods for defects;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4446&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Thorpe, C. W.;
T1 - Campestrol and \b/-sitosterol content of some vegetable oils
CT - Campestrol and \b/-sitosterol content of some vegetable oils
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1085
EP - 1087
AD - Division of Chemistry and Physics, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-3728; Language: English; Chemical Name: Campestrol--85165-97-5; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The free and total campestrol and \b/-sitosterol content of 48 samples of crude and refined corn, cottonseed, soybean and peanut oils are reported. The results show that the ratio of \b/-sitosterol to campestrol may be used to identify an individual oil and tend to confirm that sterols are lost during the refining of the crude oils.
KW - Campestrol--oils-;
KW - Chromatography, thin layer--oils--vegetable, campestrol and \b/-sitosterol constituents;
KW - Sitosterols--oils--vegetable, analysis, TLC-GLC;
KW - Chromatography, gas--oils--vegetable, campestrol and \b/-sitosterol constituents;
KW - Oils--vegetable--campestrol, and \b/-sitosterol constituents, TLC-GLC;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3728&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fritz, J. C.;
AU - Pla, G. W.;
T1 - Application of the animal hemoglobin repletion test to measurement of iron availability in foods
CT - Application of the animal hemoglobin repletion test to measurement of iron availability in foods
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/09/01/
VL - 55
IS - Sep
SP - 1128
EP - 1132
AD - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4126; Language: English; Chemical Name: Iron--7439-89-6; References: 18; Journal Coden: JANCA2; Section Heading: Drug Analysis; Methodology; Abstract Author: Douglas L. Thompson
N2 - The bioavailability of iron in a number of foods was determined by the hemoglobin repletion method in chicks and/or rats.
KW - Iron--availability-;
KW - Drugs, availability--iron--tests, animal hemoglobin repletion method;
KW - Food--iron--availability, animal hemoglobin repletion test method;
KW - Methodology--drugs, availability--iron, animal hemoglobin repletion test;
KW - Metabolism--iron--availability, from food, animal hemoglobin repletion test;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4126&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frandsen, A. M
AU - MacClendon, B. J.
AU - Chang, J. J.
AU - Creighton, W. E.
T1 - The effect of oral rinsing with sodium fluoride on the gingiva of children.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/09//
VL - 80
IS - 5
M3 - Article
SP - 445
EP - 448
SN - 0029845X
AB - The effect of a weekly mouthrinsing with a 0.2 % sodium fluoride solution on the gingiva of children was investigated using a double-blind technique. One hundred and twenty-seven Grade 2 children (6-7 years old) and 126 Grade 6 children (12-13 years old) of Negro and Caucasian background formed the study groups. In each age group, fluoride and placebo subgroups were formed which were balanced as to sex, race and number. Assessments were made for the presence of gingival inflammation, plaque and calculus on six selected permanent teeth. The results indicated that in neither age group was the degree of gingivitis influenced by the fluoride mouthrinse. Further, no differences between the two age groups in degree of gingivitis and amount of plaque were noted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUMS
KW - PERIODONTIUM
KW - SODIUM fluoride
KW - FLUORIDES
KW - CHILDREN
KW - MOUTH
KW - PERIODONTICS
N1 - Accession Number: 13238240; Frandsen, A. M 1; MacClendon, B. J. 2,3; Chang, J. J. 2,3; Creighton, W. E. 4; Source Information: 1972, Vol. 80 Issue 5, p445; Subject: GUMS; Subject: PERIODONTIUM; Subject: SODIUM fluoride; Subject: FLUORIDES; Subject: CHILDREN; Subject: MOUTH; Subject: PERIODONTICS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1973-05076-001
AN - 1973-05076-001
AU - Kaufman, Arthur
AU - Brickner, Philip W.
AU - Varner, Richard
AU - Mashburn, William
T1 - Tranquilizer control.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 1972/09//
VL - 221
IS - 13
SP - 1504
EP - 1506
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
N1 - Accession Number: 1973-05076-001. PMID: 5068649 Partial author list: First Author & Affiliation: Kaufman, Arthur; U. S. Public Health Service Indian Hosp., Rapid City, S.D. Release Date: 19730301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Drug Abuse; Drug Therapy; Mental Health Programs; Tranquilizing Drugs. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 3. Issue Publication Date: Sep, 1972.
AB - Describes a comprehensive program to reduce the distribution of tranquilizing drugs in a clinic serving an American Indian population of 6,000. The program yielded a 52% decrease in tranquilizers dispensed from the clinic and a 33% decrease in the total number of prescriptions written for these drugs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - control program
KW - tranquilizer distribution in clinic for American Indians
KW - 1972
KW - American Indians
KW - Drug Abuse
KW - Drug Therapy
KW - Mental Health Programs
KW - Tranquilizing Drugs
KW - 1972
DO - 10.1001/jama.221.13.1504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1973-05076-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - TANNER, JAMES T.
AU - FRIEDMAN, MELVIN H.
AU - LINCOLN, DAVID N.
AU - FORD, LEONARD A.
AU - JAFFEE, MAX
T1 - Mercury Content of Common Foods Determined by Neutron Activation Analysis.
JO - Science
JF - Science
Y1 - 1972/09/22/
VL - 177
IS - 4054
M3 - Article
SP - 1102
EP - 1103
SN - 00368075
AB - The mercury contents in samples of flour, sugar, nonfat dry milk, potatoes, hamburger, chicken breast, shrimp, liver, eggs, and whole milk were determined by neutron activation analysis. The mercury was separated by anion exchange chromatography and precipitated as the sulfide. The mercury concentrations for all these foods were below 50 parts per billion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117018; TANNER, JAMES T. 1; FRIEDMAN, MELVIN H. 1; LINCOLN, DAVID N. 1; FORD, LEONARD A. 2; JAFFEE, MAX 2; Affiliations: 1: Division of Chemistry and Physics, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204; 2: Division of Drug Chemistry, Food and Drug Administration; Issue Info: 9/22/1972, Vol. 177 Issue 4054, p1102; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kaufman, A.;
AU - Brickner, P. W.;
AU - Varner, R.;
AU - Mashburn, W.;
T1 - Tranquilizer control
CT - Tranquilizer control
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1972/09/25/
VL - 221
IS - Sep 25
SP - 1504
EP - 1506
AD - Reprints: 175 West 13th Street, New York, New York 10011
AD - U. S. Public Health Service Indian Hospital, Rapid City, South Dakota
N1 - Accession Number: 10-1399; Language: English; References: 18; Journal Coden: JAMAAP; Section Heading: Sociology, Economics and Ethics; Pharmacy Practice
N2 - A comprehensive program to reduce the distribution of tranquilizing drugs was established in a clinic serving an American Indian population of 6,000. Clinic staff, pharmacists, patients, and other community physicians were informed about the general problem of tranquilizer drug abuse. Individual counseling, written material and mental health referrals were helpful in freeing patients from drug use. The program yielded a 52% decrease in tranquilizing drugs dispensed from the clinic and a 33% decrease in the total number of prescriptions written for these drugs.
KW - Tranquilizers--distribution--control, program, in clinic;
KW - Drug distribution systems--tranquilizers--control, program, in clinic;
KW - Pharmacists--role--tranquilizers, distribution, control, program, in clinic;
KW - Drug information--tranquilizers--program, in clinic, reduces abuse;
KW - Drug abuse--tranquilizers--control, program, in clinic;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1399&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ARKO, ROBERT J.
T1 - Neisseria gonorrhoeae: Experimental Infection of Laboratory Animals.
JO - Science
JF - Science
Y1 - 1972/09/29/
VL - 177
IS - 4055
M3 - Article
SP - 1200
EP - 1201
SN - 00368075
AB - Experimlental Neisseria gonorrhoeae infections were established in five species of smnall laboratory animals (rabbits, guinea pigs, hamsters, mice, and rats) after subcutaneolusly implanted chamnbers were inioculated with gonococci. The chamber fluid was easily available for study or culture. A systemic itmmune response was indicated by hemnagglutination assay. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85138471; ARKO, ROBERT J. 1; Affiliations: 1: Laboratory Division, Center for Disease Control, Public Health Service, Atlanta, Georgia 30333; Issue Info: 9/29/1972, Vol. 177 Issue 4055, p1200; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Objectionable microorganisms in nonsterile drugs and cosmetics
CT - Objectionable microorganisms in nonsterile drugs and cosmetics
JO - Drug Cosmet. Ind.
JF - Drug Cosmet. Ind.
Y1 - 1972/10/01/
VL - 111
IS - Oct
SP - 51
EP - 56
AD - Drug Microbiology Branch, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 11-1391; Language: English; References: 33; Journal Coden: DCINAQ; Section Heading: Pharmaceutical Technology; Microbiology; Abstract Author: Douglas L. Thompson
N2 - An outline of the various factors involved in the value judgment that a given microorganism is objectionable and that such organisms pose a health hazard under special environmental situations in which the product is used is presented. A list of objectionable organisms for products used on damaged epithelium, for oral drugs, for eye, genitourinary and topical products is included. A summary of host-microbe-product factors determining that a microbial species is objectionable is presented in table format.
KW - Contamination--microbiological--drugs, nonsterile and cosmetics, objectionable organisms, criteria;
KW - Cosmetics--contamination--microbiological, objectionable, discussion;
KW - Drugs--nonsterile--contamination, microbiological, objectionable, discussion;
KW - Bacteria--contamination--drugs, nonsterile and cosmetics, objectionable, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1391&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bryan, P.;
T1 - DESI (Drug Efficacy Study Implementation) who?
CT - DESI (Drug Efficacy Study Implementation) who?
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1972/10/01/
VL - 6
IS - Oct
SP - 11
EP - 15
SN - 03621332
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland
N1 - Accession Number: 10-1888; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - A review of the National Academy of Sciences/National Research Council evaluation of 16,573 drug claims on 3000 drugs marketed between 1938 and 1962 and the implementation of action by the Drug Efficacy Study Implementation section of the FDA based on these evaluations is discussed.
KW - Drug Efficacy Study Implementation--programs--review;
KW - Food and Drug Administration (U.S.)--Drug Efficacy Study Implementation--programs, review;
KW - National Academy of Sciences--National Research Council--Drug Efficacy Study Implementation, programs, review;
KW - Drugs, clinical effectiveness--National Academy of Sciences--National Research Council, Drug Efficacy Study Implementation, programs, review;
KW - Regulations--Food and Drug Administration (U.S.)--Drug Efficacy Study Implementation, programs, review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-1888&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Holak, W.;
T1 - Analysis of cacodylate injections by NMR spectroscopy
CT - Analysis of cacodylate injections by NMR spectroscopy
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/10/01/
VL - 61
IS - Oct
SP - 1635
EP - 1638
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 11-5000; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Cacodylate--injections-;
KW - Injections--cacodylate--spectrometry, nuclear magnetic resonance;
KW - Spectrometry, nuclear magnetic resonance--cacodylate--injections;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-5000&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Archer, Victor E.
T1 - Mercury Content of Human Tissues.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/11//
VL - 62
IS - 11
M3 - Letter
SP - 1442
EP - 1442
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented " Mercury Content of Human Tissues," by Jack Kevorkian in the April 1972 issue.
KW - Mercury in the body
KW - Letters to the editor
N1 - Accession Number: 24294319; Archer, Victor E. 1; Affiliations: 1: Coordinator, Western Area Activities of the Division of Field Studies and Clinical Investigations, National Institute for Occupational Safety and Health, Dept. of HEW., P.O. Box 8137, Salt Lake City, Utah 84108; Issue Info: Nov1972, Vol. 62 Issue 11, p1442; Thesaurus Term: Mercury in the body; Subject Term: Letters to the editor; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Taliaferro, B. A.;
T1 - Occurrence of particulate matter in reconstituted antibiotics
CT - Occurrence of particulate matter in reconstituted antibiotics
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1972/11/01/
VL - 26
IS - Nov-Dec
SP - 290
EP - 295
AD - Center for Antibiotic Analysis, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 10-4443; Language: English; References: 7; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - By means of the membrane filter method, reconstituted, antibiotic I.V. products prepared by a number of companies have been surveyed for foreign particulate matter. The results indicate a variation among companies as to the amount of particulate matter found in their products.
KW - Antibiotics--contamination--particles, in reconstituted products;
KW - Filters--membrane--particles, in reconstituted antibiotics;
KW - Particles--contamination--antibiotics, reconstituted, membrane filters;
KW - Contamination--particles--antibiotics, reconstituted;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4443&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Arret, B.;
T1 - Automation of antibiotic assays
CT - Automation of antibiotic assays
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1972/11/01/
VL - 26
IS - Nov-Dec
SP - 296
EP - 301
AD - Center for Antibiotic Analysis, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 10-4594; Language: English; Journal Coden: BUYRAI; Section Heading: Drug Analysis
N2 - A discussion of the automation of the microbiological assay for potency of antibiotics is presented. The Microbiological Assay Branch of the National Center for Antibiotic Analysis of the Food and Drug Administration performs 100,000 individual assays per year and has recently developed several automated instruments which are capable of eliminating in part the manual operations required in performing these tests. This results in removing tedious and fatiguing duties, thereby releasing personnel for more specialized work.
KW - Antibiotics--analysis--microbiological, automation;
KW - Analysis--antibiotics--microbiological, automation;
KW - Automation--analysis--microbiological, of antibiotic potency;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4594&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fricke, F. L.;
T1 - Analysis of drugs in pharmaceuticals, using simple extraction and semiautomated gas-liquid chromatography
CT - Analysis of drugs in pharmaceuticals, using simple extraction and semiautomated gas-liquid chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1162
EP - 1167
AD - Food and Drug Administration, 1141 Central Parkway, Cincinnati, Ohio 45202
N1 - Accession Number: 10-4809; Language: English; References: 30; Journal Coden: JANCA2; Section Heading: Drug Analysis; Pharmaceutical Chemistry; Abstract Author: Douglas L. Thompson
N2 - A standardized and automated solvent extraction and TLC procedure for drug analysis was developed that was suitable for interlaboratory collaboration. The liquid phase used was Dexsil 300, a polycarboranesiloxane. Results by this method and the official or other applicable methods are compared. It is demonstrated that content uniformity analyses can be made by using this procedure. Data for 61 individual drugs, including barbiturates, antihistamines, analgesics and tranquilizers, is presented. Combination products were also studied.
KW - Chromatography, gas--drugs--standard extraction and chromatographic conditions, method for interlaboratory use;
KW - Analysis--interlaboratory--standardized GLC method for drugs;
KW - Standards--chromatography, gas--method for interlaboratory use;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4809&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hamilton, J. L., Jr.;
AU - Naviasky, H. S.;
AU - Ment, W. M.;
T1 - Effect of maleic acid on the ultraviolet absorption of some antihistamine maleate salts
CT - Effect of maleic acid on the ultraviolet absorption of some antihistamine maleate salts
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1168
EP - 1170
AD - Food and Drug Administration, 900 Madison Avenue, Baltimore, Maryland 21201
N1 - Accession Number: 10-3968; Language: English; Chemical Name: Dexbrompheniramine--132-21-8 Dexchlorpheniramine--25523-97-1 Chlorpheniramine--132-22-9; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Data presented show that erroneously low assay results are obtained when UV absorption (below 280 nm.) of antihistamine maleate sample solutions, previously extracted from alkaline aqueous media into organic solvents, are compared with antihistamine maleate standard sample solutions diluted directly in the same acid medium. Such errors are shown to be caused by the UV absorption properties of the maleic acid moiety. Recovery data for some antihistamine maleate standards, using several official procedures and one nonofficial assay method are included. Drugs studied were: dexbrompheniramine, dexchlorpheniramine, and chlorpheniramine maleates.
KW - Dexbrompheniramine--spectrometry, ultraviolet-;
KW - Dexchlorpheniramine--spectrometry, ultraviolet-;
KW - Chlorpheniramine--spectrometry, ultraviolet-;
KW - Antihistamines--spectrometry, ultraviolet--errors, effect of maleic acid moiety on UV absorption;
KW - Errors--analysis--antihistamines, effect of maleic acid on UV absorption of maleate salts;
KW - Spectrometry, ultraviolet--errors--antihistamines, effect of maleic acid on UV absorption of some antihistamine maleate salts;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3968&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Myrick, J. W.;
AU - Page, D. P.;
AU - Pfabe, Y. H.;
T1 - Semiautomated method for the analysis of methyltestosterone tablets and testosterone suspensions
CT - Semiautomated method for the analysis of methyltestosterone tablets and testosterone suspensions
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1175
EP - 1179
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 10-3969; Language: English; Chemical Name: Methyltestosterone--58-18-4 Testosterone--58-22-0; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Described is the analysis of methyltestosterone (I) in single tablets at a level of 5-25 mg./tablet or testosterone (II) in suspensions. The active ingredient in an alcoholic solution was acidified and the drug was extracted into chloroform. Reaction with isonicotinic acid hydrazide produced a yellow color, which was recorded on a colorimeter. Relative standard deviations of the method did not exceed 1.38 and 1.50% for (I) tablets and (II) suspensions, respectively.
KW - Methyltestosterone--colorimetry-;
KW - Testosterone--colorimetry-;
KW - Colorimetry--methyltestosterone--semiautomated, tablets;
KW - Colorimetry--testosterone--semiautomated, suspension;
KW - Suspensions--testosterone--colorimetry, semiautomated;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3969&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rudy, B. C.;
AU - Mahn, F. P.;
AU - Senkowski, B. Z.;
AU - Sheppard, A. J.;
AU - Hubbard, W. D.;
T1 - Collaborative study of the gas-liquid chromatography assay for vitamin E
CT - Collaborative study of the gas-liquid chromatography assay for vitamin E
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1211
EP - 1218
AD - Reprints: Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204
AD - Analytical Research Laboratory, Hoffman\M/La Roche Incorporated, Nutley, New Jersey 07110
N1 - Accession Number: 10-4810; Language: English; Chemical Name: Vitamin E--1406-18-4; References: 16; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The GLC method used in this collaborative study proved to be very specific and more rapid and precise than the currently used compendial colorimetric method for vitamin E. The method is useful for the analysis of \a/-tocopherol, and \a/-tocopheryl acetate and \a/-tocopheryl acid succinate. Analyses were also carried out on mixed tocopherol concentrate, multivitamin tablets and multivitamin soft gelatin capsules.
KW - Vitamin E--chromatography, gas-;
KW - Chromatography, gas--vitamin E;
KW - Vitamins--multiple--chromatography, gas, vitamin E constituents;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4810&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ulsamer, A. G.;
T1 - Determination of hexachlorophene in mammalian tissues by gas-liquid chromatography
CT - Determination of hexachlorophene in mammalian tissues by gas-liquid chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1294
EP - 1299
AD - Division of Toxicology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-0323; Language: English; Trade Name: G-11; Generic Name: Hexachlorophene; Chemical Name: Hexachlorophene--70-30-4; Therapeutic Class: (38:00); AHFS Class: Disinfectants hexachlorophene; References: 10; Journal Coden: JANCA2; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - Gas chromatography of the acetyl or methyl derivative of hexachlorophene (G-11) extracted from animal tissues using an ether-absolute ethyl alcohol solvent is described.
KW - Hexachlorophene--chromatography, gas-;
KW - Chromatography, gas--hexachlorophene--tissue levels, in animals;
KW - Metabolism--hexachlorophene--tissue levels, GLC, in animals;
KW - Disinfectants--hexachlorophene--tissue levels, GLC, in animals;
KW - Tissue levels--hexachlorophene--chromatography, gas, in animals;
KW - Drugs, body distribution--hexachlorophene--tissue levels, chromatography, gas, in animals;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0323&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Iverson, J. L.;
T1 - Gas-liquid chromatographic detection of palm kernel and coconut oils in cacao butter (theobroma oil)
CT - Gas-liquid chromatographic detection of palm kernel and coconut oils in cacao butter (theobroma oil)
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1319
EP - 1322
AD - Division of Food Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4813; Language: English; Trade Name: Cacao butter; Generic Name: Theobroma oil; Chemical Name: Palm oil--8002-75-3; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Theobroma oil--adulteration-;
KW - Palm oil--adulteration-;
KW - Adulteration--theobroma oil--detection, GLC, of palm kernel and coconut oils;
KW - Coconut oils--adulteration--theobroma oil, detection, GLC;
KW - Chromatography, gas--theobroma oil--detection, of palm kernel and coconut oil adulterants;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4813&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jeffus, M. T.;
AU - Kenner, C. T.;
T1 - Quantitative determination and confirmation of low levels of diethylstilbestrol in feeds
CT - Quantitative determination and confirmation of low levels of diethylstilbestrol in feeds
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1972/11/01/
VL - 55
IS - Nov
SP - 1345
EP - 1353
AD - Food and Drug Administration, 3032 Bryan Street, Dallas, Texas 75204
N1 - Accession Number: 10-3564; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Diethylstilbestrol--feeds-;
KW - Feeds--diethylstilbestrol--analysis, quantitative;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3564&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Bacon, C R T
T1 - An interactive, versatile, three-dimensional display, manipulation and plotting system for biomedical research
JO - Journal of Chemical Documentation
JF - Journal of Chemical Documentation
Y1 - 1972/11//
VL - 12
IS - 4
M3 - Article
SP - 234
EP - 237
SN - 00219576
AB - Computer graphics provides a valuable tool for the representation and a better understanding of structures, both small and large. Accurate and rapid construction, manipulation, and plotting of structures, such as macromolecules as complex as hemoglobin, are performed by a collection of computer programs and a time-sharing computer. The programs and techniques are described, and examples of the system are given.
N1 - Accession Number: ISTA0800898; Bacon, C R T 1; Affiliations: 1 : National Institute Of Health, Public Health Service, Bethesda, Maryland.; Source Info: November 1972, Vol. 12 Issue 4, p234; Note: Update Code: 0800; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Hertzman, Marc
T1 - Group Health Work in a Hostile Environment: The U.S. Public Health Service.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1972/12//
VL - 62
IS - 12
M3 - Letter
SP - 1566
EP - 1567
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented about the inadequate public health care services in the U.S.
KW - Public health
KW - Letters to the editor
N1 - Accession Number: 24294353; Hertzman, Marc 1; Affiliations: 1: SA Surg, U.S. Public Health Service, 2214 Hering Ave., Bronx, N.Y. 10469; Issue Info: Dec1972, Vol. 62 Issue 12, p1566; Thesaurus Term: Public health; Subject Term: Letters to the editor; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Lowell, G. J.;
T1 - Determination of isomeric composition of amphetamine mixtures from melting points of monohydrogen succinate salts
CT - Determination of isomeric composition of amphetamine mixtures from melting points of monohydrogen succinate salts
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/12/01/
VL - 61
IS - Dec
SP - 1976
EP - 1978
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education, and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 11-4996; Language: English; Chemical Name: Amphetamine--300-62-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Pharmaceutics
KW - Amphetamine--mixtures-;
KW - Isomers--amphetamine--mixtures, composition, from melting points of monohydrogen succinate salts;
KW - Melting points--amphetamine--mixtures, isomeric composition, monohydrogen succinate salts;
KW - Central nervous system stimulants--amphetamine--mixtures, isomeric composition, from melting points of monohydrogen succinate salts;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4996&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Roos, R. W.;
T1 - Separation and determination of barbiturates in pharmaceuticals by high speed liquid chromatography
CT - Separation and determination of barbiturates in pharmaceuticals by high speed liquid chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1972/12/01/
VL - 61
IS - Dec
SP - 1979
EP - 1984
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 11-4999; Language: English; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Barbiturates--chromatography, liquid--high speed;
KW - Sedatives and hypnotics--barbiturates--chromatography, liquid, high speed;
KW - Chromatography, liquid--barbiturates--high speed;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4999&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Brown, D. W. C.;
T1 - Potential systemic hazards of topically applied mercurials
CT - Potential systemic hazards of topically applied mercurials
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1972/12/01/
VL - 23
IS - Dec
SP - 875
EP - 886
SN - 00379832
AD - Food and Drug Administration, Department of Health, Education and Welfare, Washington, D.C. 20204
N1 - Accession Number: 11-1137; Language: English; Chemical Name: Phenylmercuric acetate--62-38-4 Mercury--7439-97-6; Therapeutic Class: (84:24); AHFS Class: Creams mercury; References: 25; Journal Coden: JSCCA5; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Douglas L. Thompson
N2 - Phenylmercuric acetate and ammoniated mercury absorption data are presented as background for a retrospective study of 6 female chronic users of skin bleach creams containing ammoniated mercury who showed elevated mercury levels in tissues and symptoms suggestive of mercury accumulation. It was shown that urine, blood, or hair levels of mercury in chronic users of mercurial bleach creams were elevated above normal and were consistent with the experimental penetration data. In 3 cases the urinary mercury levels reported were within the range of values reported for inorganic mercury intoxication. The possible usefulness of determining methyl mercury in hair when total mercury is elevated, as a means of finding out if exposure is due to inorganic or alkyl mercury, is noted.
KW - Phenylmercuric acetate--absorption-;
KW - Mercury--ammoniated-;
KW - Absorption--mercury--and toxicity, in humans;
KW - Metabolism--mercury--absorption, and toxicity, in humans;
KW - Creams--mercury--toxicity, following absorption, in humans;
KW - Bleaches--creams--skin, mercury absorption, and toxicity, in humans;
KW - Drugs, body distribution--mercury--following absorption from skin bleach creams, in humans;
KW - Blood levels--mercury--and toxicity, following absorption from skin bleach creams, in humans;
KW - Excretion--mercury--following absorption from skin bleach creams, in humans;
KW - Toxicity--mercury--creams, bleaches, following absorption, in humans;
KW - Methodology--mercury--toxicity, detection;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Wiggins, Geraldine L.
AU - Hollis, Dannie G.
AU - Weaver, Robert
T1 - Prevalence of Serogroups and Sulfonamide Resistance of Meningococci from the Civilian Population in the United States, 1964-1970.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/01//
VL - 63
IS - 1
M3 - Article
SP - 59
EP - 65
PB - American Public Health Association
SN - 00900036
AB - This is a comprehensive review of the occurrence of serogroups and resistance to sulfonamides of meningococci among civilians in the United States for the period 1964–1970. The data are correlated with clinical sources of isolation and the geographical area from which the isolates were obtained, with emphasis on changing trends in serogroup prevalence and/or sulfadiazine susceptibility. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Population
KW - Epidemics
KW - Cerebrospinal meningitis
KW - Sulfonamides
KW - Immune serums
KW - Blood products
KW - Microbial sensitivity tests
KW - United States
N1 - Accession Number: 24294390; Wiggins, Geraldine L. 1; Hollis, Dannie G. 1; Weaver, Robert 1; Affiliations: 1: Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, Georgia. 30333; Issue Info: Jan1973, Vol. 63 Issue 1, p59; Thesaurus Term: Communicable diseases; Thesaurus Term: Population; Thesaurus Term: Epidemics; Subject Term: Cerebrospinal meningitis; Subject Term: Sulfonamides; Subject Term: Immune serums; Subject Term: Blood products; Subject Term: Microbial sensitivity tests; Subject: United States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Miles, C. I.;
AU - Schenk, G. H.;
T1 - Fluorescence and phosphorescence of phenylethylamines and barbiturates: analysis of amphetamine and barbiturate preparations
CT - Fluorescence and phosphorescence of phenylethylamines and barbiturates: analysis of amphetamine and barbiturate preparations
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1973/01/01/
VL - 45
IS - Jan
SP - 130
EP - 136
AD - U.S. Food and Drug Administration, 1560 East Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 10-2612; Language: English; Chemical Name: Amphetamine--300-62-9 Phenobarbital--50-06-6; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants amphetamine (28:24); AHFS Class: Sedatives and hypnotics phenobarbital; References: 25; Journal Coden: ANCHAM; Section Heading: Drug Analysis
N2 - The fluorescence and phosphorescence excitation spectra of 7 phenylethylamines, 10 barbiturates, and certain model compounds have been examined and correlated. Fluorescence quantum efficiencies in air have been measured together with molar absorptivities to give a practical relative indication of the fluorescence intensities of these molecules. The case of phenobarbital is unusual in that its phosphorescence emission maximum at 370 nm. is at higher energies than its fluorescence emission maximum at 415 nm. It is shown that each emission arises from a different chromophore in phenobarbital. Fluorometric analysis was used to assay pharmaceutical preparations for single components and for amphetamine plus barbiturate. The results compare favorably with those obtained by conventional analyses.
KW - Amphetamine--fluorometry-;
KW - Phenobarbital--fluorometry-;
KW - Phenylethylamines--fluorometry--and phosphorescence;
KW - Barbiturates--fluorometry--and phosphorescence;
KW - Fluorometry--phenylethylamines--fluorescence and phosphorescence excitation spectra;
KW - Fluorometry--amphetamine--fluorescence and phosphorescence excitation spectra;
KW - Central nervous system stimulants--amphetamine--fluorometry, and phosphorescence;
KW - Central nervous system stimulants--phenylethylamines--fluorometry, and phosphorescence;
KW - Sedatives and hypnotics--phenobarbital--fluorometry, and phosphorescence;
KW - Sedatives and hypnotics--barbiturates--fluorometry, and phosphorescence;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-2612&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hanson, A. J.;
AU - Nighswander, R. M.;
AU - Verhulst, J. H.;
T1 - Monitoring of intravenous solutions
CT - Monitoring of intravenous solutions
JO - Hosp. Formul. Manage.
JF - Hosp. Formul. Manage.
Y1 - 1973/01/01/
VL - 8
IS - Jan
SP - 17
EP - 21
AD - U. S. Public Health Service Hospital, New Orleans, Louisiana
N1 - Accession Number: 10-4396; Language: English; References: 17; Journal Coden: HOFMAY; Section Heading: Environmental Toxicity; Institutional Pharmacy Practice; Abstract Author: Paul R. Webster
N2 - A study to determine the incidence of bacterial and fungal contamination in I.V. solutions and their administration sets is presented. Random bottles were taken from 4 wards (representing 60% of total I.V.'s used) and sampled as follows: (1) immediately after admixture; (2) after attachment of administration set; (3) administration set after use; and (4) bottle after use. Nursing and pharmacy prepared bottles were used. Of the 90 solutions sampled, 35 had all 4 samples taken. Contamination rates of 11.4% for regular I.V.'s and 15.4% for hyperalimentation fluids were reported. It is concluded that I.V. monitoring by pharmacy is justified as a result of these findings.
KW - Statistics--contamination--injections, intravenous, by bacteria and fungi;
KW - Contamination--microbiological--injections, intravenous, bacterial and fungal, statistics;
KW - Additives--injections--intravenous, contamination, bacterial and fungal, statistics;
KW - Pharmacists, hospital--additives--injections, intravenous, contamination, bacterial and fungal;
KW - Injections--intravenous--contamination, bacterial and fungal, statistics;
KW - Toxicity, environmental--injections--intravenous, contamination, bacterial and fungal, statistics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Landrigan, P. J.;
AU - Huber, D. H.;
AU - Murphy, G. D., III;
AU - Creech, W. B.;
AU - Bryan, J. A.;
T1 - Protective efficacy of immune serum globulin in hepatitis A: a statistical approach
CT - Protective efficacy of immune serum globulin in hepatitis A: a statistical approach
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/01/01/
VL - 223
IS - Jan 1
SP - 74
EP - 75
AD - Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, Department of Health, Education and Welfare, Atlanta, Georgia 30333
N1 - Accession Number: 10-2478; Language: English; References: 7; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - In a community outbreak of hepatitis A (person-to-person transmission) the efficacy of immune serum globulin prophylaxis among patients' family members was between 87% and 98%. Immune serum globulin efficacy was determined by means of a formula used previously to measure live virus vaccine efficacy in epidemics.
KW - Globulins--immune serum--prophylaxis, hepatitis A, in humans;
KW - Serums--globulins--immune, prophylaxis, hepatitis A, in humans;
KW - Immunization--hepatitis A--globulins, immune serum, prophylaxis, in humans;
KW - Methodology--globulins--immune serum, prophylaxis, hepatitis A, in humans;
KW - Statistics--globulins--immune serum, prophylaxis, hepatitis A, in humans;
KW - Hepatitis--globulins--immune serum, prophylaxis, in humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Fluorometric determination of estradiol valerate in sesame oil or ethyl oleate injectables. II. Collaborative study
CT - Fluorometric determination of estradiol valerate in sesame oil or ethyl oleate injectables. II. Collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/01/01/
VL - 56
IS - Jan
SP - 86
EP - 87
AD - Food and Drug Administration, 1521 West Pico Boulevard, Los Angeles, California 90015
N1 - Accession Number: 10-4360; Language: English; Chemical Name: Estradiol--50-28-2; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Estradiol--valerate-;
KW - Fluorometry--estradiol--valerate, in sesame oil or ethyl oleate injections;
KW - Injections--estradiol--valerate, fluorometry, in sesame oil or ethyl oleate;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Clark, C. C.;
T1 - Collaborative study of an on column periodate reaction method for the analysis of phenylpropanolamine hydrochloride in elixirs
CT - Collaborative study of an on column periodate reaction method for the analysis of phenylpropanolamine hydrochloride in elixirs
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/01/01/
VL - 56
IS - Jan
SP - 100
EP - 104
AD - Food and Drug Administration, 900 Madison Avenue, Baltimore, Maryland 21201
N1 - Accession Number: 10-4356; Language: English; Chemical Name: Phenylpropanolamine--14838-15-4; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents phenylpropanolamine; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Elixirs of phenylpropanolamine (I) HCl were quantitatively analyzed by UV spectrometry. I is separated from water soluble impurities and strong acids by elution from a weakly basic Celite column. Further cleanup is accomplished by retention of I on a weakly acidic column while the weak acids, weak bases, and organic soluble neutrals are eluted. I is eluted from the column after neutralization with NH\IF/3\BS/ and is converted to benzaldehyde via an on-column periodate reaction. The sample studied consisted of 2 commercial and 2 synthetic elixirs. Recoveries of the synthetic elixirs averaged 100.1 and 101.8% for mixtures containing 5.05 and 12.52 mg./5 ml. I, respectively. The means and standard deviations for the commercial preparations were 4.75 0.12 and 12.34 0.16 mg./5 ml.
KW - Phenylpropanolamine--spectrometry, ultraviolet-;
KW - Sympathomimetic agents--phenylpropanolamine--spectrometry, ultraviolet, elixirs, following on-column periodate reaction;
KW - Chromatography, column--phenylpropanolamine--elixirs, on-column periodate reaction and UV spectrometry;
KW - Elixirs--phenylpropanolamine--spectrometry, ultraviolet, following on-column periodate reaction;
KW - Spectrometry, ultraviolet--phenylpropanolamine--elixirs, following on-column periodate reaction;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheinin, E. B.;
AU - Benson, W. R.;
AU - Smith, M. M., Jr.;
T1 - Disulfiram determination by proton magnetic resonance spectroscopy and by colorimetry
CT - Disulfiram determination by proton magnetic resonance spectroscopy and by colorimetry
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/01/01/
VL - 56
IS - Jan
SP - 124
EP - 127
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-5101; Language: English; Trade Name: Tetraethylthiuram disulfide; Generic Name: Disulfiram; Chemical Name: Disulfiram--97-77-8; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Disulfiram (tetraethylthiuram disulfide) was determined as a pure compound and in tablets by proton magnetic resonance(PMR) spectrometry at the 100-480 mg. level and by colorimetric technique involving cuprous iodide at the 50 mg. level. The tablet excipients did not interfere with the analysis. The average result for disulfiram in a tablet composite was 100.8 1.4% of label claim by PMR and 100.7 0.4% by the colorimetric method.
KW - Disulfiram--spectrometry, nuclear magnetic resonance-;
KW - Spectrometry, nuclear magnetic resonance--disulfiram--tablets, and pure substance, and colorimetry;
KW - Colorimetry--disulfiram--tablets, and pure substance, and NMR spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kling, R. E.;
T1 - Determination of neostigmine bromide by ion-pairing column chromotography
CT - Determination of neostigmine bromide by ion-pairing column chromotography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/01/01/
VL - 56
IS - Jan
SP - 128
EP - 131
AD - Food and Drug Administration, Second and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 10-4358; Language: English; Chemical Name: Neostigmine--59-99-4; Therapeutic Class: (12:04); AHFS Class: Parasympathomimetic agents neostigmine; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A rapid and sensitive method for the assay of neostigmine bromide (I) in tablets and ophthalmic solutions was developed. (I) is isolated from its excipients by the ion-pairing partition column chromatography followed by UV determination of its alkaline hydrolysis product. Standard recoveries from simulated tablet mixtures and ophthalmic solutions averaged 99.8%.
KW - Neostigmine--chromatography, column-;
KW - Chromatography, column--neostigmine--ion pairs;
KW - Parasympathomimetic agents--neostigmine--chromatography, column, ion pairs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Goldwitz, B. A.;
AU - Turczan, J. W.;
T1 - NMR analysis of pharmaceuticals. VIII. Determination of trimethadione in various dosage forms
CT - NMR analysis of pharmaceuticals. VIII. Determination of trimethadione in various dosage forms
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/01/01/
VL - 62
IS - Jan
SP - 115
EP - 117
SN - 00223549
AD - Food and Drug Administration, U.S. Department of Health, Education and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 11-4995; Language: English; Chemical Name: Trimethadione--127-48-0; Therapeutic Class: (28:12); AHFS Class: Anticonvulsants trimethadione; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Trimethadione--spectrometry, nuclear magnetic resonance-;
KW - Spectrometry, nuclear magnetic resonance--trimethadione--dosage forms;
KW - Anticonvulsants--trimethadione--spectrometry, nuclear magnetic resonance;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rosenstein, G.;
AU - Freeman, M.;
AU - Standard, A. L.;
AU - Weston, N.;
T1 - Warning: the use of Lomotil in children
CT - Warning: the use of Lomotil in children
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1973/01/01/
VL - 51
IS - Jan
SP - 132
EP - 134
SN - 00314005
AD - Division of Metabolic and Endocrine Drug Products, Food and Drug Administration, Department of Health, Education, and Welfare, Rockville, Maryland
N1 - Accession Number: 11-0732; Language: English; Trade Name: Lomotil; Generic Name: Diphenoxylate; Chemical Name: Diphenoxylate--915-30-0 Atropine--51-55-8; Therapeutic Class: (56:08); AHFS Class: Antidiarrhea agents diphenoxylate, combination, atropine (56:08); AHFS Class: Antidiarrhea agents atropine, combination, diphenoxylate; References: 19; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Brenda Sue Martinez
N2 - Package inserts for Lomotil (2.5 mg. diphenoxylate HCl, combination, atropine sulfate 25 mcg.) were revised and its use in children under 2 years of age contraindicated due to numerous poisoning reports.
KW - Diphenoxylate--combination, atropine-;
KW - Atropine--combination, diphenoxylate-;
KW - Food and Drug Administration (U.S.)--diphenoxylate, combination, atropine--package inserts, contraindications, in children under 2 years of age;
KW - Package inserts--diphenoxylate, combination, atropine--contraindications, FDA, in children under 2 years of age;
KW - Contraindications--diphenoxylate, combination, atropine--package inserts, FDA, in children under 2 years of age;
KW - Pediatrics--diphenoxylate, combination, atropine--contraindications, in children under 2 years of age;
KW - Poisoning--diphenoxylate, combination, atropine--pediatrics, contraindication, in children under 2 years of age;
KW - Toxicity--diphenoxylate, combination, atropine--poisoning, pediatrics, contraindications, in children under 2 years of age;
KW - Antidiarrhea agents--diphenoxylate, combination, atropine--contraindications in children under 2 years of age;
KW - Food and Drug Administration (U.S.)--atropine, combination, diphenoxylate--package inserts, contraindications, in children under 2 years of age;
KW - Package inserts--atropine, combination, diphenoxylate--contraindications, FDA, in children under 2 years of age;
KW - Contraindications--atropine, combination, diphenoxylate--package inserts, FDA, in children under 2 years of age;
KW - Pediatrics--atropine, combination, diphenoxylate--contraindications, in children under 2 years of age;
KW - Poisoning--atropine, combination, diphenoxylate--pediatrics, contraindications, in children under 2 years of age;
KW - Toxicity--atropine, combination, diphenoxylate--poisoning, pediatrics, contraindications, in children under 2 years of age;
KW - Antidiarrhea agents--atropine, combination, diphenoxylate--contraindications, in children under 2;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1973-25494-001
AN - 1973-25494-001
AU - Proskauer, Stephen
AU - Rolland, Ruick S.
T1 - Youth who use drugs: Psychodynamic diagnosis and treatment planning.
JF - Journal of the American Academy of Child Psychiatry
JO - Journal of the American Academy of Child Psychiatry
Y1 - 1973/01//
VL - 12
IS - 1
SP - 32
EP - 47
CY - US
PB - Lippincott Williams & Wilkins
N1 - Accession Number: 1973-25494-001. PMID: 4683867 Other Journal Title: Journal of the American Academy of Child & Adolescent Psychiatry. Partial author list: First Author & Affiliation: Proskauer, Stephen; U.S. Public Health Service, Indian Hosp., Tuba City, Ariz. Other Publishers: Elsevier Science. Release Date: 19730901. Correction Date: 20110207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Drug Rehabilitation; Psychodiagnosis. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Page Count: 16. Issue Publication Date: Jan, 1973.
AB - Discusses the proper approach to use with youthful drug addicts. Effective treatment or judicious withholding of treatment requires a diagnostic understanding of the individual and of his life situation. 3 psychodynamic categories of youthful drug users are outlined for purposes of treatment planning: (a) experimental drug users, (b) depressive drug users, and (c) characterological drug users. For the 1st group, deliberate noninterference or informal counseling is usually sufficient. Depressive drug users need psychotherapy. Characterologically crippled drug users benefit most from residential participation in a self-help program or methadone maintenance. It is concluded that community mental health clinics and child guidance clinics have a crucial role to play in providing diagnostic evaluation and therapy and in coordinating community resources for young drug users. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychodynamic diagnosis & treatment planning
KW - young drug addicts
KW - 1973
KW - Drug Addiction
KW - Drug Rehabilitation
KW - Psychodiagnosis
KW - 1973
DO - 10.1097/00004583-197301000-00003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1973-25494-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - TEISINGER, J.
AU - XINTARAS, C.
AU - PFITZER, E.
T1 - Prague International Lead Panel: Effects of Atmospheric Lead on Biological Systems.
JO - Science
JF - Science
Y1 - 1973/01/12/
VL - 179
IS - 4069
M3 - Article
SP - 197
EP - 198
SN - 00368075
N1 - Accession Number: 85135822; TEISINGER, J. 1; XINTARAS, C. 2,3; PFITZER, E. 4,5; Affiliations: 1: Institute of Industrial Hygiene and Occupational Diseases, Prague, Czechoslovakia; 2: Environmental Protection Agency, Cincinnati, Ohio 45202; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio 45202; 4: University of Cincinnati, Cincinnati; 5: Hoffmann-La Roche, Inc., Nutley, New Jersey; Issue Info: 1/12/1973, Vol. 179 Issue 4069, p197; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1974-05379-001
AN - 1974-05379-001
AU - Shore, James H.
AU - Kinzie, J. David
AU - Hampson, John L.
AU - Pattison, E. Mansell
T1 - Psychiatric epidemiology of an Indian village.
JF - Psychiatry: Journal for the Study of Interpersonal Processes
JO - Psychiatry: Journal for the Study of Interpersonal Processes
JA - Psychiatry
Y1 - 1973/02//
VL - 36
IS - 1
SP - 70
EP - 81
CY - US
PB - Guilford Publications
SN - 0033-2747
N1 - Accession Number: 1974-05379-001. Other Journal Title: Psychiatry: Interpersonal and Biological Processes. Partial author list: First Author & Affiliation: Shore, James H.; Portland Area Indian Health Service, Ore. Other Publishers: Taylor & Francis. Release Date: 19740301. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Behavior Disorders; Epidemiology; Mental Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 12. Issue Publication Date: Feb, 1973.
AB - Measured psychiatric impairment in a Pacific Northwest Indian village. Ss were 100 (of a total population of 500) adults from an isolated fishing and lumbering tribe. A structured and standardized sociodemographic field interview was conducted. Data from an informant and health records on physical, social, and drinking history were collected. Major psychiatric diagnoses were: alcoholism (27%, 10% female), psychoneurotic reactions (18%, 17% female), and psychophysiologic reactions (9%). Alcoholism was seen to be the major psychiatric problem, and probably the major health problem in the village. Sex was an important determinant of type of illness, with men more likely to become alcoholic and women to become psychoneurotic. (17 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric epidemiology
KW - male vs female Pacific Northwest Indians
KW - 1973
KW - American Indians
KW - Behavior Disorders
KW - Epidemiology
KW - Mental Disorders
KW - 1973
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Sterility assurance: product testing versus biological indicators
CT - Sterility assurance: product testing versus biological indicators
JO - Aust. J. Pharm. Sci.
JF - Aust. J. Pharm. Sci.
Y1 - 1973/03/01/
VL - NS2
IS - Mar
SP - 1
EP - 8
AD - Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-0191; Language: English; References: 22; Journal Coden: AJPSBP; Section Heading: Pharmaceutical Technology; Microbiology; Abstract Author: Douglas L. Thompson
N2 - It is argued that the use of biological indicators provides more rigorous control of the assurance of sterility from a sterilization cycle than does a sterility test of treated products that had only a low level of random natural contaminants prior to sterilization. The insufficiencies of product sterility tests in monitoring sterilization procedures are discussed. The use of microbial death rate kinetics and biological indicators is urged in order to obtain low probabilities of survivors in sterilized materials. It was concluded that the best proof to certify that a lot of sterilized materials has a high probability of being sterile is the destruction of calibrated doses of microorganisms of defined resistance carried by a few samples from the lot.
KW - Sterility--control--indicators, biological, recommended use;
KW - Standards--sterility--indicators, biological, use recommended;
KW - Tests--sterility--indicators, biological, use recommended;
KW - Indicators--biological--use, recommended in sterility testing;
KW - Sterilization--tests--indicators, biological, use recommended;
KW - Control, quality--sterilization--indicators, biological, use recommended;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cornelis, W. A.;
AU - Christian, D. G.;
AU - Fortner, C. L.;
T1 - Hodgkin's disease
CT - Hodgkin's disease
JO - J. Am. Pharm. Assoc.
JF - J. Am. Pharm. Assoc.
Y1 - 1973/03/01/
VL - NS13
IS - Mar
SP - 147
EP - 154
AD - Patient Care Pharmacy Service, National Cancer Institute, Baltimore Cancer Research Center, U.S. Public Health Service Hospital, Baltimore, Maryland
N1 - Accession Number: 12-6205; Language: English; References: 6; Publication Type: Current Therapeutic Concepts; Journal Coden: JPHAA3; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Drucella Andersen
N2 - The pathology; staging; clinical course and complications; therapy, including radiation treatments and chemotherapy; and prognosis of Hodgkin's disease is presented.
KW - Hodgkin's disease--therapy--discussion, in patients;
KW - Radiation--Hodgkin's disease--chemotherapy, discussion, in patients;
KW - Nomenclature--Hodgkin's disease--discussion;
KW - Antineoplastic agents--Hodgkin's disease--therapy, discussion, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ramsey, L. L.;
T1 - Role of the scientist in an era of consumerism
CT - Role of the scientist in an era of consumerism
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/03/01/
VL - 56
IS - Mar
SP - 239
EP - 245
AD - Office of Compliance, Bureau of Foods, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 11-1964; Language: English; References: 14; Journal Coden: JANCA2; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and Ethics; Abstract Author: Douglas L. Thompson
N2 - The role of the consumer in promoting legislation to protect the public is discussed including consumer pressure leading to safer food and drug laws. The scientists' need to recognize the role of consumerism and to educate consumers is also discussed. Books relating to consumerism and laws enacted in response to consumer pressure are noted.
KW - Health care--laws--enactment, role of consumer;
KW - Safety--drugs--and foods, effects, consumer pressures;
KW - Consumers--laws--role;
KW - Scientists--laws--food, and drugs, role and relationships to consumers;
KW - Laws--consumers--role, in safety of food and drugs;
KW - Education--consumers--role, scientists;
KW - Research--consumers--role, and relationships to scientists;
KW - Food--safety--laws, consumers role and scientists responsibility;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bathalter, W. H.;
AU - Levine, J.;
T1 - Chromatographic-UV spectrophotometric determination of menadione in tablets
CT - Chromatographic-UV spectrophotometric determination of menadione in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/03/01/
VL - 56
IS - Mar
SP - 361
EP - 362
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-1756; Language: English; Chemical Name: Menadione--58-27-5; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A chromatographic-UV spectrophotometric method for the determination of menadione in tablets, utilizing the conversion of menadione to menadione sodium bisulfite, was developed. The sample is treated with sodium bisulfite and the resultant menadione sodium bisulfite is analyzed by the method of Johnson. A column prewash with chloroform removes impurities or degradation products present in the original menadione sample. The menadione is then eluted with an ammonia-saturated chloroform solution. The method worked equally well on coated and uncoated tablets and it has the advantage of determining only the amount of menadione and not degradation products present in the sample.
KW - Menadione--spectrometry, ultraviolet-;
KW - Tablets--menadione--spectrometry, ultraviolet, and column chromatography;
KW - Chromatography, column--menadione--and UV spectrometry, tablets;
KW - Spectrometry, ultraviolet--menadione--and column chromatography, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1973-28582-001
AN - 1973-28582-001
AU - Kroes, William H.
AU - Libby, William L.
T1 - Relative power of selected encoding categories for the organization of free recall in children.
JF - The Journal of Genetic Psychology: Research and Theory on Human Development
JO - The Journal of Genetic Psychology: Research and Theory on Human Development
JA - J Genet Psychol
Y1 - 1973/03//
VL - 122
IS - 1
SP - 9
EP - 15
CY - US
PB - Heldref Publications
SN - 0022-1325
SN - 1940-0896
N1 - Accession Number: 1973-28582-001. Other Journal Title: The Pedagogical Seminary; The Pedagogical Seminary and Journal of Genetic Psychology. Partial author list: First Author & Affiliation: Kroes, William H.; U.S. Public Health Service, Cincinnati, O. Other Publishers: Taylor & Francis. Release Date: 19731101. Correction Date: 20100823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Associative Processes; Classification (Cognitive Process); Free Recall; Sex Linked Developmental Differences. Minor Descriptor: Semantic Differential. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Page Count: 7. Issue Publication Date: Mar, 1973.
AB - Conducted a free-recall experiment with 4th, 6th, and 8th graders (N = 384) to test the relative power of 2 taxonomic, 2 semantic-differential, and 2 sense-impression word classes in facilitating recall. Findings show that across all grades, Ss exhibited a significantly greater tendency to recall and cluster taxonomic and semantic-differential over sense-impression word classes. 6th and 8th graders recalled more words over all word classes than 4th graders. Females recalled more words than males across all 3 grade levels and all 6 word classes. There was no grade or sex effect for clustering. An interpretation of this difference is presented. (16 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex & grade
KW - free recall of taxonomic vs. semantic-differential vs. sense-impression word classes
KW - 4th vs. 6th vs. 8th graders
KW - 1973
KW - Age Differences
KW - Associative Processes
KW - Classification (Cognitive Process)
KW - Free Recall
KW - Sex Linked Developmental Differences
KW - Semantic Differential
KW - 1973
DO - 10.1080/00221325.1973.10533164
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1973-28583-001
AN - 1973-28583-001
AU - Kroes, William H.
T1 - Study of frustrative nonreward in children.
JF - The Journal of Genetic Psychology: Research and Theory on Human Development
JO - The Journal of Genetic Psychology: Research and Theory on Human Development
JA - J Genet Psychol
Y1 - 1973/03//
VL - 122
IS - 1
SP - 89
EP - 92
CY - US
PB - Heldref Publications
SN - 0022-1325
SN - 1940-0896
N1 - Accession Number: 1973-28583-001. Other Journal Title: The Pedagogical Seminary; The Pedagogical Seminary and Journal of Genetic Psychology. Partial author list: First Author & Affiliation: Kroes, William H.; U.S. Public Health Service, Cincinnati, O. Other Publishers: Taylor & Francis. Release Date: 19731101. Correction Date: 20100823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Frustration; Rewards. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Page Count: 4. Issue Publication Date: Mar, 1973.
AB - Hypothesized that an enhancement of goal objects would occur for Ss who were frustrated from receiving these goal objects in a study with 72 middle-class children (mean age = 8 yr.). 3 department measures were used to assess the frustration effects: size estimation, verbal evaluation, and selective attention. Ss were divided into frustration, partial frustration, and reward groups. Results were nonsignificant, in contrast to previous studies which show very significant effects for lower-class children. A strong behavioral effect was obtained but dissipated during the delay interval between the performance and measurement phase. This suggests that the increased frustration tolerance of middle-class children results in a more rapid dissolution of the frustration effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - frustration vs. partial frustration vs. reward
KW - size estimation & verbal evaluation & selective attention
KW - middle-class school age children
KW - 1973
KW - Frustration
KW - Rewards
KW - 1973
DO - 10.1080/00221325.1973.10533174
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1973-28583-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Fluorometric determination of epinephrine in low dosage injections and in lidocaine hydrochloride-epinephrine combinations
CT - Fluorometric determination of epinephrine in low dosage injections and in lidocaine hydrochloride-epinephrine combinations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/04/01/
VL - 62
IS - Apr
SP - 669
EP - 671
SN - 00223549
AD - Food and Drug Administration, Los Angeles, California 90015
N1 - Accession Number: 12-2227; Language: English; Chemical Name: Epinephrine--51-43-4; Therapeutic Class: (12:12); AHFS Class: Sympathomimetic agents epinephrine; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Epinephrine--alone and with lidocaine-;
KW - Fluorometry--epinephrine--alone and with lidocaine, injections;
KW - Sympathomimetic agents--epinephrine--alone and with lidocaine, injections, fluorometry;
KW - Injections--epinephrine--alone and with lidocaine, fluorometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2227&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Alleva, F. R.;
T1 - Failure of neonatal injection of hexachlorophene to affect reproduction in hamsters
CT - Failure of neonatal injection of hexachlorophene to affect reproduction in hamsters
JO - Toxicology
JF - Toxicology
Y1 - 1973/04/01/
VL - 1
IS - Apr
SP - 357
EP - 360
AD - Division of Drug Biology, Food and Drug Administration, U.S. Department of Health, Education and Welfare, Washington, D.C. 20204
N1 - Accession Number: 11-3229; Language: English; Chemical Name: Hexachlorophene--70-30-4; Therapeutic Class: (38:00); AHFS Class: Disinfectants hexachlorophene; References: 9; Journal Coden: TXCYAC; Section Heading: Toxicity
N2 - Neonatal administration of a near lethal dose of hexachlorophene had no effect on time of puberty, estrous cycle regularity, fertility, or body weight in hamsters (Mesocricetus auratus). This indicates that the drug does not interfere with neonatal sexual differentiation of the hypothalamic center that later controls pituitary gonadotropin release in adults. Hexachlorophene dissolved in corn oil was injected S.C. in a dose of 10 microliters/g. to hamsters from 2 to 12 days old.
KW - Hexachlorophene--toxicity-;
KW - Toxicity--hexachlorophene--lack, S.C., on reproduction, in hamsters;
KW - Disinfectants--hexachlorophene--toxicity, lack, S.C. on reproduction, in hamsters;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Whelton, A.;
AU - Carter, G. G.;
AU - Bryant, H. H.;
AU - Porteous, L. A.;
AU - Walker, W. G.;
T1 - Carbenicillin concentrations in normal and diseased kidneys\M/a therapeutic consideration
CT - Carbenicillin concentrations in normal and diseased kidneys\M/a therapeutic consideration
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1973/05/01/
VL - 78
IS - May
SP - 659
EP - 662
SN - 00034819
AD - O'Neill Research Laboratories of the Department of Medicine, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland and The National Center for Antibiotic Analysis, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C.
N1 - Accession Number: 11-0928; Language: English; Chemical Name: Carbenicillin--4697-36-3; References: 32; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution
N2 - The intrarenal distribution pattern of carbenicillin was investigated in 10 normal dogs and in 5 severely diseased patients undergoing renal transplantation. The patients received an I.V. infusion of 5 g. carbenicillin 2 hours before nephrectomy. In the hydropenic state in dogs, cortical, papillary, and urinary levels may be as much as 3, 17 1/2, or 535 times greater, respectively, than the concomitant serum level. Hydration abolishes the increased cortico-papillary-urinary gradient pattern. Severe disease in human kidneys markedly decreases the renal parenchymal penetration of carbenicillin and significantly reduces the urine concentrations. This decreased renal tissue concentration averages 4 to 14 times less than the concentration in normal renal tissue. These changes in the renal and urinary pharmacokinetics of carbenicillin, in health and disease, have not been previously defined; they must be taken into account in the therapy of pyelonephritis and urinary tract infections.
KW - Carbenicillin--tissue levels-;
KW - Pharmacokinetics--carbenicillin--tissue levels, in dogs and humans;
KW - Metabolism--carbenicillin--tissue levels, in dogs and humans;
KW - Tissue levels--carbenicillin--renal, in dogs and humans;
KW - Drugs, body distribution--carbenicillin--renal, tissue levels, in dogs and humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0928&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Tabulations of 1972 reports (from poison control centers)
CT - Tabulations of 1972 reports (from poison control centers)
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1973/05/01/
VL - Pages
IS - May-Jun
SP - 1
EP - 9
AD - Food and Drug Administration, Bureau of Drugs, 5401 Westbard Avenue, Bethesda, Maryland 20016
N1 - Accession Number: 11-3714; Language: English; Chemical Name: Aspirin--50-78-2; Journal Coden: NCPBBY; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2 - During 1972 the Clearinghouse processed 160,824 ingestion case reports from 548 poison control centers in 47 states. The top 25 categories of products involved in ingestions by children under 5 years of age are tabulated for the years 1969 through 1972. These 25 categories represent 68% of the reported ingestions within this age group. While aspirin remains the single substance most frequently ingested by children, it continues to decline both absolutely and as a percent of ingestions by the under 5 age group. Ingestion of soaps, detergents, cleaners, antihistamines and cold medicines, paints, chemicals, and vitamins are shown to be increasing.
KW - Aspirin--poisoning-;
KW - Poisoning--statistics--United States, 1972;
KW - Pediatrics--poisoning--statistics, 1972, United States;
KW - Toxicity--poisoning--statistics, 1972, United States;
KW - Statistics--poisoning--United States, 1972;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3714&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Skoglund, R. D.;
AU - Paulsen, C. A.;
T1 - Danazol-testosterone combination: a potentially effective means for reversible male contraception. Preliminary report
CT - Danazol-testosterone combination: a potentially effective means for reversible male contraception. Preliminary report
JO - Contraception (USA)
JF - Contraception (USA)
Y1 - 1973/05/01/
VL - 7
IS - May
SP - 357
EP - 365
SN - 00107824
AD - Department of Medicine, University of Washington and the Division of Endocrinology, United States Public Health Service Hospital, Seattle, Washington
N1 - Accession Number: 11-0464; Language: English; Chemical Name: Danazol--17230-88-5 Testosterone--58-22-0; Therapeutic Class: (68:12); AHFS Class: Contraceptives, injectable testosterone, combination, danazol; References: 6; Journal Coden: CCPTAY; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Danazol was administered to normal adult male volunteers alone or in combination with testosterone propionate or testosterone enanthate to determine the effects on sperm concentration. The drugs were administered for 4 months. Danazol orally produced a modest reduction in sperm counts but danazol plus testosterone propionate 10 mg. I.M. 3 times weekly reduced sperm counts to below 2 million/ml. in 3 of 4 men. Danazol plus testosterone enanthate 200 mg. I.M. once monthly dropped sperm counts to less than 1 million/ml. in 3 of 3 men within 8 weeks. Androgen withdrawal symptoms were not observed when testosterone was added to the danazol as a combined regimen. It is suggested that danazol plus relatively small doses of testosterone may prove to be an effective and safe male contraceptive.
KW - Danazol--alone and with testosterone-;
KW - Testosterone--combination, danazol-;
KW - Contraceptives, injectable--danazol, combination, testosterone--male, effects, sperm count, in humans;
KW - Contraceptives, injectable--testosterone, combination, danazol--male, effects, sperm count, in humans;
KW - Contraception--male--danazol, alone and with testosterone, in humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0464&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dow, M. L.;
T1 - Semiautomated colorimetric determination of methanamine and methenamine mandelate in tablets
CT - Semiautomated colorimetric determination of methanamine and methenamine mandelate in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 647
EP - 652
AD - National Center for Drug Analysis, Food and Drug Administration, St. Louis, Missouri 63101
N1 - Accession Number: 10-4123; Language: English; Chemical Name: Methenamine--100-97-0; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A semiautomated chromotropic acid colorimetric procedure was collaboratively studied by 6 laboratories, both as a composite assay and as an individual methenamine tablet assay method. Results agreed well with the USP and NF methods. The coefficients of variation ranged from 0.54 to 2.48%. The method has been adopted for the analysis of coated and uncoated tablets of methenamine mandelate, methenamine, and methenamine with sodium biphosphate.
KW - Methenamine--colorimetry-;
KW - Colorimetry--ethenamine--tablets, semiautomated;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4123&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Alber, L. L.;
AU - Overton, M. W.;
AU - Smith, D. E.;
T1 - Minicomputer-automatic analysis system for pharmaceuticals
CT - Minicomputer-automatic analysis system for pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 659
EP - 666
AD - Food and Drug Administration, 433 West Van Buren Street, Chicago, Illinois 60607
N1 - Accession Number: 10-4120; Language: English; References: 18; Journal Coden: JANCA2; Section Heading: Drug Analysis; Information Processing and Literature
N2 - An economical computerized system for the automated analysis of drugs is described. With a minicomputer hardware system costing less than $50,000, software was developed to process data from 16 automatic analyzers operating simultaneously. In addition, the calculation routine has been made available to many other laboratories and analysts in an off-line mode by using an already established TWX communication system. Calculation time for a 30 tablet analysis, including standard deviation and coefficient of variance, is reduced from a 2 hr. manual operation to 8 min. for the off-line mode.
KW - Automation, data processing, computers--analysis--drugs, use of minicomputer;
KW - Analysis--computers--drugs, automated system using minicomputer;
KW - Costs--analysis--automated, drugs, minicomputer hardware system;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4120&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cunningham, C. G.;
AU - Barkan, S.;
T1 - Determination of propoxyphene and aspirin in combinations
CT - Determination of propoxyphene and aspirin in combinations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 667
EP - 668
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4116; Language: English; Chemical Name: Propoxyphene--469-62-5 Aspirin--50-78-2; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - Mixtures of propoxyphene HCl and aspirin and propoxyphene napsylate and aspirin were assayed by partition chromatography of capsule and tablet dosage forms. Following separation, the concentration of each component is determined by UV spectrometry.
KW - Propoxyphene--combination, aspirin-;
KW - Aspirin--combination, propoxyphene-;
KW - Chromatography, column--propoxyphene, combination, aspirin--and UV spectrometry, tablets and capsules;
KW - Spectrometry, ultraviolet--propoxyphene, combination, aspirin--following column chromatography, tablets and capsules;
KW - Spectrometry, ultraviolet--aspirin, combination, propoxyphene--following column chromatography, tablets and capsules;
KW - Chromatography, column--aspirin, combination, propoxyphene--and UV spectrometry, tablets and capsules;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4116&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Goldwitz, B. A.;
T1 - Nuclear magnetic resonance analysis of pharmaceuticals. IX. Methenamine and methenamine mandelate in tablets
CT - Nuclear magnetic resonance analysis of pharmaceuticals. IX. Methenamine and methenamine mandelate in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 669
EP - 673
AD - Food and Drug Administration, 850 Third Avenue, Brooklyn, New York 11232
N1 - Accession Number: 10-4121; Language: English; Chemical Name: Methenamine--100-97-0 Mandelic acid--90-64-2; References: 37; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - An NMR procedure is described by which methenamine and mandelic acid are simultaneously determined in methenamine and methenamine mandelate tablets. Maleic acid was chosen as the internal standard and dimethylformamide-acetone-acetonitrile (10+25+65) as the solvent. The solvent system was selected to resolve the problems of solubility of methenamine and its salt with mandelic acid, overlapping of the resonance signals of the components, and potential decomposition of methenamine. Known standard and commercial preparations were analyzed and the results were compared to those of official USP and NF procedures. The NMR technique, when applied to the determination of methenamine and methenamine mandelate in tablets, is rapid, simple, and specific and can provide an assay with an accuracy of 1-2%.
KW - Methenamine--spectrometry, nuclear magnetic resonance-;
KW - Mandelic acid--spectrometry, nuclear magnetic resonance-;
KW - Spectrometry, nuclear magnetic resonance--methenamine--tablets;
KW - Spectrometry, nuclear magnetic resonance--mandelic acid--tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, J. H.;
T1 - Collaborative study of a spectrophotometric method for the determination of dienestrol in pharmaceuticals
CT - Collaborative study of a spectrophotometric method for the determination of dienestrol in pharmaceuticals
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 674
EP - 676
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4114; Language: English; Chemical Name: Dienestrol--84-17-3; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Dienestrol is separated from excipient matter, degradation products, and other drugs present by column partition chromatography, converted to a substituted indene by acid-induced isomerization, and determined by UV spectrometry. Standard deviations obtained for the 4 samples used in the study, containing approximately 0.1 and 0.5 mg. dienestrol, ranged from 1.81 to 3.04. The most critical step in the method is the use of suitable ether. Analyses were carried out on commercial coated tablets and an uncoated tablet.
KW - Dienestrol--analysis-;
KW - Tablets--dienestrol--analysis, UV spectrometry following chromatography;
KW - Spectrometry, ultraviolet--dienestrol--tablets, following column chromatographic separation;
KW - Chromatography, column--dienestrol--tablets, and UV spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazzari, F. R.;
T1 - Collaborative study of a column chromatographic method for chlorothiazide, methyclothiazide, and polythiazide
CT - Collaborative study of a column chromatographic method for chlorothiazide, methyclothiazide, and polythiazide
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 677
EP - 680
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4113; Language: English; Chemical Name: Chlorothiazide--58-94-6 Methyclothiazide--135-07-9 Polythiazide--346-18-9; Therapeutic Class: (40:28); AHFS Class: Diuretics chlorothiazide (40:28); AHFS Class: Diuretics methyclothiazide (40:28); AHFS Class: Diuretics polythiazide; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - Tablet samples of chlorothiazide, polythiazide, and methyclothiazide were analyzed by UV spectrometry following a column chromatographic separation.
KW - Chlorothiazide--spectrometry, ultraviolet-;
KW - Methyclothiazide--spectrometry, ultraviolet-;
KW - Polythiazide--spectrometry, ultraviolet-;
KW - Diuretics--chlorothiazide--spectrometry, ultraviolet, following column chromatographic separation, tablets;
KW - Diuretics--methyclothiazide--spectrometry, ultraviolet, following column chromatographic separation, tablets;
KW - Diuretics--polythiazide--spectrometry, ultraviolet, following column chromatographic separation, tablets;
KW - Spectrometry, ultraviolet--chlorothiazide--tablets, following column chromatographic separation;
KW - Spectrometry, ultraviolet--methyclothiazide--tablets, following column chromatographic separation;
KW - Spectrometry, ultraviolet--polythiazide--tablets, following column chromatographic separation;
KW - Chromatography, column--chlorothiazide--tablets, and UV spectrometry;
KW - Chromatography, column--methyclothiazide--tablets, and UV spectrometry;
KW - Chromatography, column--polythiazide--tablets, and UV spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stricklin, M. C.;
T1 - Collaborative study of a colorimetric determination of benztropine mesylate in tablets and injections
CT - Collaborative study of a colorimetric determination of benztropine mesylate in tablets and injections
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 681
EP - 683
AD - Food and Drug Administration, 50 Fulton Street, San Francisco, California 94102
N1 - Accession Number: 10-4112; Language: English; Chemical Name: Benztropine--86-13-5; Therapeutic Class: (12:08); AHFS Class: Parasympatholytic agents benztropine; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Benztropine is extracted from 0.2 N sulfuric acid with bromophenol blue in chloroform and the absorbance of the dye complex formed is measured at about 410 nm. Simulated powder, tablet and injection preparations were analyzed.
KW - Benztropine--mesylate-;
KW - Colorimetry--benztropine--mesylate, tablets and injections;
KW - Parasympatholytic agents--benztropine--mesylate, colorimetry, tablets and injections;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4112&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Falcone, N.;
T1 - Gas chromatographic determination of ethanol and isopropanol or acetone in drugs
CT - Gas chromatographic determination of ethanol and isopropanol or acetone in drugs
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 684
EP - 688
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 10-4354; Language: English; Chemical Name: Alcohols, ethyl--64-17-5 Alcohols, isopropyl--67-63-0 Acetone--67-64-1; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A gas chromatographic method for the identification and determination of ethyl alcohol and isopropyl alcohol or acetone in drug products was studied. The technique involves direct injection of an aqueous dilution of the product and is therefore simple and direct. Elixirs, tinctures, syrups and simulated products were analyzed. Recoveries and standard deviations for all 3 components were satisfactory. A solution containing any of the 3 components as low as 0.002% can be analyzed successfully. The method is applicable for the analysis of ethyl alcohol in combination with isopropanol or acetone.
KW - Alcohols, ethyl--chromatography, gas-;
KW - Alcohols, isopropyl--chromatography, gas-;
KW - Acetone--chromatography, gas-;
KW - Chromatography, gas--alcohols, ethyl--alone, or with isopropyl alcohol or acetone;
KW - Chromatography, gas--alcohols, isopropyl--alone, or with ethyl alcohol;
KW - Chromatography, gas--acetone--alone, or with ethyl alcohol;
KW - Elixirs--chromatography, gas--constituents, ethyl alcohol;
KW - Tinctures--chromatography, gas--constituents, ethyl alcohol;
KW - Syrups--chromatography, gas--constituents, ethyl alcohol;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brunner, C. A.;
T1 - Collaborative study of the method for the analysis of trisulfapyrimidine preparations by thin layer chromatography
CT - Collaborative study of the method for the analysis of trisulfapyrimidine preparations by thin layer chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 689
EP - 691
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4351; Language: English; Chemical Name: Sulfadiazine--68-35-9 Sulfamerazine--127-79-7 Sulfamethazine--57-68-1; Journal Coden: JANCA2; Section Heading: Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - A thin layer chromatographic method for the analysis of tablets and suspensions containing mixtures of sulfadiazine, sulfamerazine, and sulfamethazine is presented. Results are reported for total trisulfapyrimidine (triple sulfonamides) as well as individual results.
KW - Sulfadiazine--combination, sulfamerazine, sulfamethazine-;
KW - Sulfamerazine--combination, sulfadiazine, sulfamethazine-;
KW - Sulfamethazine--combination, sulfadiazine, sulfamerazine-;
KW - Sulfonamides--triple--chromatography, thin layer;
KW - Chromatography, thin layer--sulfonamides--triple;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kolinski, R. E.;
T1 - Collaborative study of a semiautomated method for the analysis of sodium warfarin and dicumarol tablets
CT - Collaborative study of a semiautomated method for the analysis of sodium warfarin and dicumarol tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 692
EP - 696
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 10-4350; Language: English; Chemical Name: Warfarin--81-81-2 Dicumarol--66-76-2; Therapeutic Class: (20:12.04); AHFS Class: Anticoagulants warfarin (20:12.04); AHFS Class: Anticoagulants dicumarol; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A semiautomated extraction and UV spectrometry determination for sodium warfarin and dicumarol (bishydroxycoumarin) tablets was studied by 7 laboratories. For warfarin, coefficients of variation ranged from 0.35 to 2.10%. For dicumarol, coefficients of variation ranged from 0.39 to 2.19%.
KW - Warfarin--spectrometry, ultraviolet-;
KW - Dicumarol--spectrometry, ultraviolet-;
KW - Spectrometry, ultraviolet--warfarin--tablets, following semiautomated extraction;
KW - Spectrometry, ultraviolet--dicumarol--tablets, following semiautomated extraction;
KW - Anticoagulants--warfarin--spectrometry, ultraviolet, following semiautomated extraction, tablets;
KW - Anticoagulants--dicumarol--spectrometry, ultraviolet, following semiautomated extraction, tablets;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4350&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brolund, G. V.;
AU - Haskins, E. W.;
AU - Hudson, G. A.;
T1 - Calculation of turbidimetric microbiological vitamin assay results, using an APL/360 computer program
CT - Calculation of turbidimetric microbiological vitamin assay results, using an APL/360 computer program
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/05/01/
VL - 56
IS - May
SP - 754
EP - 757
AD - Division of Nutrition, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4089; Language: English; References: 3; Journal Coden: JANCA2; Section Heading: Pharmaceutics; Information Processing and Literature; Abstract Author: Douglas L. Thompson
N2 - A comparison of manual and automated methods for the calculation of results from microbiological vitamin assays indicated the validity of the computer program for these calculations. A flow chart of the program is included.
KW - Automation, data processing, computers--analysis--vitamins, calculation of turbidimetric microbiological assay results;
KW - Vitamins--analysis--calculations, computer, of turbidimetric microbiological assay results;
KW - Analysis--microbiological--turbidimetry, computer calculation of vitamin assay results;
KW - Turbidimetry--vitamins--calculations, computer, of microbiological assay results;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4089&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rubin, R. H.;
AU - Sikes, R. K.;
AU - Gregg, M. B.;
T1 - Human rabies immune globulin: clinical trials and effects on serum anti-\g/-globulins
CT - Human rabies immune globulin: clinical trials and effects on serum anti-\g/-globulins
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/05/07/
VL - 224
IS - May 7
SP - 871
EP - 874
AD - Epidemiology Program, Center for Disease Control, Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 11-2205; Language: English; Chemical Name: Rabies immune globulin--0; References: 20; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Investigational Drugs
N2 - Human derived rabies immune globulin (I) was administered I.M. to 24 male volunteers according to 2 dose schedules: either 20 ml. (equivalent to the WHO recommendation of 40 I.U./kg. for equine derived antiserum) or one-fourth of the WHO recommendation (10 I.U./kg.) The 10 I.U./kg. dose gave barely detectable antirabies antibody titers and is not considered of therapeutic value. The 20 ml. dose has higher, longer lasting titers of antirabies antibody than the comparable doses of equine antiserum currently in use. There were no untoward reactions. Before administration of I, all 24 volunteers had IgG class anti-IgG antibodies (mean titer, 114 mcg./ml); 22 of 24 had IgA class anti-IgG antibodies (mean titer, 65 mcg./ml.); and none of the 24 had IgM class anti-IgG antibodies. Administration of I caused no significant change in these titers.
KW - Rabies immune globulin--human-;
KW - Globulins--immune rabies--human, effects, on serum anti-\g/-globulins, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2205&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hartwell, T. D.
AU - Gaylor, D. W.
T1 - Estimating Variance Components for Two-Way Disproportionate Data with Missing Cells by the Method of Unweighted Means.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1973/06//
VL - 68
IS - 342
M3 - Article
SP - 379
SN - 01621459
AB - The method of unweighted means, which is a simple analysis based on cell means, has been limited to designs where every cell has at least one observation. Here, the method of unweighted means is examined with regard to estimating the variance components for a two-way classification with unequal numbers of observations in the cells and with one or more cells having no observations. In particular, two estimating procedures based upon the method of unweighted means are developed to estimate the variance components for a design with missing cells. These two unweighted means procedures are then examined numerically. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of variance
KW - ESTIMATION theory
KW - RANDOM variables
KW - APPROXIMATION theory
KW - MISSING data (Statistics)
KW - EQUATIONS
KW - EXPERIMENTAL design
KW - ITERATIVE methods (Mathematics)
N1 - Accession Number: 4601877; Hartwell, T. D. 1; Gaylor, D. W. 2; Affiliations: 1: Statistician, Statistics Research Division, Research Triangle institute, Research Triangle Park, N.C. 27709.; 2: Chief, Biometry Division, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079.; Issue Info: Jun73, Vol. 68 Issue 342, p379; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: ESTIMATION theory; Thesaurus Term: RANDOM variables; Thesaurus Term: APPROXIMATION theory; Subject Term: MISSING data (Statistics); Subject Term: EQUATIONS; Subject Term: EXPERIMENTAL design; Subject Term: ITERATIVE methods (Mathematics); Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4601877&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Maibach, H. I.;
T1 - Antimicrobials: experimental contact sensitization in man
CT - Antimicrobials: experimental contact sensitization in man
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1973/06/01/
VL - 24
IS - Jun
SP - 399
EP - 421
SN - 00379832
AD - Dermal Toxicity Branch, Division of Toxicology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-1149; Language: English; Trade Name: Formalin--DP-300; Generic Name: Formaldehyde; Triclosan; Chemical Name: Formaldehyde--50-00-0 Bronopol--52-51-7 Mafenide--138-39-6 Chloroacetamide--79-07-2 Propylene glycol--57-55-6 Triclocarban--101-20-2 Hexachlorophene--70-30-4 Chloroxylenol--88-04-0 Tribromsalan--87-10-5 Sorbic acid--110-44-1 Neomycin--1404-04-2 Triclosan--3380-34-5 Phenol--108-95-2; References: 19; Journal Coden: JSCCA5; Human Indicator: Yes; Section Heading: Methodology
N2 - Predicitive contact skin sensitization data have been developed for 23 antimicrobial agents using the Draize procedure on normal human test subjects. In some cases results are exploratory and involve about 50 subjects; in most cases 100 or more subjects were used and more meaningful sensitization indices obtained. The data were developed on drugs currently in use or contemplated for use as cosmetic or drug preservatives or for their germicidal properties when used on skin. Organic and inorganic mercurials, formalin (formaldehyde) bronopol, mafenide, captan and chloracetamide have relatively stronger skin sensitization potential (5% sensitization index). Propylene glycol, triclocarban, chlorinated phenolics such as hexachlorophene, chloroxylenol and dichlorophene, and parabens and tribromsalicylanilide and possibly sorbic acid appear to be relatively lower grade sensitizers (0-0.5% sensitization index). Furacin, neomycin and dibromsalicylanilide appear to have an intermediate standing in this group (sensitization index around 1). Triclosan (DP-300) failed to sensitize and photosensitize; however, a larger test population is needed to confirm this finding. Tribromsalicylanilide has some capacity for photosensitization and cross-sensitization to chemically related materials; the significance of these findings in not entirely clear.
KW - Formaldehyde--toxicity-;
KW - Bronopol--toxicity-;
KW - Mafenide--toxicity-;
KW - Captan--toxicity-;
KW - Chloroacetamide--toxicity-;
KW - Propylene glycol--toxicity-;
KW - Triclocarban--toxicity-;
KW - Hexachlorophene--toxicity-;
KW - Chloroxylenol--toxicity-;
KW - Dichlorophene--toxicity-;
KW - Tribromsalan--toxicity-;
KW - Sorbic acid--toxicity-;
KW - Furacin--toxicity-;
KW - Neomycin--toxicity-;
KW - Dibromsalicylanilide--toxicity-;
KW - Triclosan--toxicity-;
KW - Phenol--derivatives-;
KW - Anti-infective agents--toxicity--skin, contact sensitization, test, in humans;
KW - Antibacterial agents--toxicity--skin, contact sensitization, test, in humans;
KW - Antibiotics--toxicity--skin, contact sensitization, test, in humans;
KW - Mercurials--toxicity--skin, contact sensitization, test, in humans;
KW - Preservatives--toxicity--skin, contact sensitization, test, in humans;
KW - Methodology--toxicity--drugs, contact skin sensitivity, tests, in humans;
KW - Toxicity--tests--drugs, contact skin sensitivity, in humans;
KW - Parabens--toxicity--skin, contact sensitization, tests, in humans;
KW - Cosmetics--toxicity--tests, predictive contact skin sensitization, in humans;
KW - Methodology--toxicity--cosmetics, predictive contact skin sensitization, in humans;
KW - Sensitivity--tests--methodology, predictive contact skin sensitization, in humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1149&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-07192-001
AN - 1974-07192-001
AU - Bergman, Robert L.
T1 - A school for medicine men.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1973/06//
VL - 130
IS - 6
SP - 663
EP - 666
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1974-07192-001. PMID: 4701956 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Bergman, Robert L.; Indian Health Service, Window Rock, Ariz. Release Date: 19740401. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Educational Programs; Folk Medicine; Medical Personnel. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 4. Issue Publication Date: Jun, 1973.
AB - Discusses the establishment and training program of a Navajo school for medicine men. The nature of the curative ceremonies and a few perceptions of their effects are described from the psychiatrist's point of view. The author's role in teaching the medicine men and trainees something about medicine and psychiatry and their reactions to these are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - educational program
KW - medicine & psychiatry
KW - Navajo medicine men
KW - 1973
KW - American Indians
KW - Educational Programs
KW - Folk Medicine
KW - Medical Personnel
KW - 1973
DO - 10.1176/ajp.130.6.663
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1974-07192-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Sommer, A.;
AU - Khan, M.;
AU - Mosley, W. H.;
T1 - Efficacy of vaccination of family contacts of cholera cases
CT - Efficacy of vaccination of family contacts of cholera cases
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/06/02/
VL - 1
IS - Jun 2
SP - 1230
EP - 1232
SN - 00237507
AD - Epidemiology Program, Center for Disease Control, U.S. Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 10-4975; Language: English; References: 14; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Monovalent Inaba vaccine was ineffective in treating 742 family contacts of 149 cholera patients in Bangladesh with bacteriologically confirmed Vibrio cholerae Inaba infection.
KW - Cholera vaccines--monovalent Inaba-;
KW - Immunization--cholera--vaccines, monovalent Inaba, lack, effects, in treating family contacts;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4975&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Digoxin tablets: a possible problem with biological availability
CT - Digoxin tablets: a possible problem with biological availability
JO - Am. Heart J.
JF - Am. Heart J.
Y1 - 1973/07/01/
VL - 86
IS - Jul
SP - 715
AD - Bureau of Drugs (BD-40), Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 11-2689; Language: English; Chemical Name: Digoxin--20830-75-5; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs digoxin; References: 7; Publication Type: Letters; Journal Coden: AHJOA2; Section Heading: Biopharmaceutics; Abstract Author: F. James Grogan
N2 - The Food and Drug Administration (FDA) suggests that pharmacists keep for the information of physicians a record of the brand name and manufacturer or supplier, as well as the lot number of all digoxin tablets dispensed. FDA indicates that currently available information suggests that digoxin tablets from different manufacturers and suppliers may not be equally bioavailable, and therefore may not be therapeutically equivalent. The FDA also emphasizes that if a bioavailability problem does exist with regard to tableted digoxin products, it is because we have become more sophisticated in our ability to define the factors that influence drug therapy, rather than any identifiable change on the part of the industry.
KW - Digoxin--availability-;
KW - Cardiac drugs--digoxin--availability, tablets, differences, various manufacturers, discussion;
KW - Drugs, availability--digoxin--differences, tablets, various manufacturers, discussion;
KW - Equivalency--digoxin--lack, among brands, discussion;
KW - Tablets--digoxin--availability, differences, various manufacturers, discussion;
KW - Formulations--digoxin--tablets, equivalency, lack, among brands;
KW - Drugs, clinical effectiveness--digoxin--tablets, availability, differences, various manufacturers;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2689&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ellinoy, B. J.;
AU - Mays, J. F.;
AU - McSherry, P. V.;
AU - Rosenthal, L. C.;
T1 - Pharmacy outpatient monitoring program providing primary medical care to select patients
CT - Pharmacy outpatient monitoring program providing primary medical care to select patients
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1973/07/01/
VL - 30
IS - Jul
SP - 593
EP - 598
SN - 00029289
AD - Reprints: PROMIS Laboratory, Medical Center Hospital of Vermont, Burlington, Vermont 05401
AD - Pharmacy Service, USPHS Indian Health Service Hospital, Shiprock, New Mexico 87420
N1 - Accession Number: 10-3612; Language: English; References: 7; Journal Coden: AJHPA9; Section Heading: Institutional Pharmacy Practice
N2 - An operational program is described in which pharmacists provide primary outpatient medical care to patients with certain chronic illnesses. Patients with stable, drug controlled medical problems are referred to the pharmacist by a physician. General guidelines have been established by the medical and pharmacy staffs for each specific disease state covered. Using these guidelines and analyzing subjective and objective data, the pharmacist either continues the patient's drug regimen or refers the patient to the physician for further evaluation. In all cases a problem oriented progress note is entered in the health record, reflecting the data obtained and the action taken on the problem. The program has demonstrated that in a proper setting the pharmacist is capable not only of monitoring drug therapy but also of providing primary medical care.
KW - Patients--outpatients--monitoring, medical care, by pharmacists;
KW - Pharmacists, hospital--outpatients--monitoring, medical care;
KW - Pharmacy, institutional, hospital--outpatients--monitoring, medical care;
KW - Patient care--outpatients--monitoring, by pharmacists;
KW - Patient information--consultation--outpatients, monitoring, medical care, by pharmacists;
KW - Clinical pharmacy--outpatients--monitoring, medical care, by pharmacists;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-3612&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Podliska, R. J.;
AU - O'Sullivan, F. X.;
T1 - Diazepam as therapy for convulsive seizures precipitated by chemical intoxicants
CT - Diazepam as therapy for convulsive seizures precipitated by chemical intoxicants
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1973/07/01/
VL - Pages
IS - Jul-Aug
SP - 1
EP - 6
AD - Food and Drug Administration, Bureau of Drugs, 5401 Westbard Avenue, Bethesda, Maryland 20016
N1 - Accession Number: 11-0221; Language: English; Chemical Name: Diazepam--439-14-5; Therapeutic Class: (28:12); AHFS Class: Anticonvulsants diazepam (28:16.08); AHFS Class: Tranquilizers diazepam; References: 21; Journal Coden: NCPBBY; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Douglas L. Thompson
N2 - A survey of animal and human studies relating to the use of diazepam to control seizures in poison victims is presented.
KW - Diazepam--antidotes-;
KW - Anticonvulsants--diazepam--therapy, in animals and humans;
KW - Toxicity--poisoning--convulsive, therapy with diazepam, in animals and humans;
KW - Tranquilizers--diazepam--therapy, convulsive seizures, in animals and humans;
KW - Antidotes--diazepam--seizures, convulsive, in animals and humans;
KW - Poisoning--antidotes--diazepam, use in convulsive seizures, in animals and humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0221&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Yingling, G. L.;
T1 - F.D.A.'s review of over-the-counter drugs
CT - F.D.A.'s review of over-the-counter drugs
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1973/07/01/
VL - 7
IS - Jul-Dec
SP - 67
EP - 70
SN - 00928615
AD - O T C Drug Products Evaluation Staff, Bureau of Drugs, Food and Drug Administration, Rockville, Maryland
N1 - Accession Number: 12-5437; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: Lyn E. Teven
N2 - The Food and Drug Administration's decision to establish therapeutic classes for over-the-counter drugs as the most efficient method of review is explained. Labeling of all OTC drugs now on the market, as well as unapproved or misbranded drugs that have new formulations or labels, are reviewed for safety, efficacy, and accuracy by 17 panels. Selection of panels and the review procedures they follow are described, using the panel on antacids as an example.
KW - Food and Drug Administration (U.S.)--drugs, over-the-counter--labeling, class, review, procedure and panel selection;
KW - Drugs, over-the-counter--labeling--class, review, procedure and panel selection, FDA;
KW - Labeling--drugs, over-the-counter--class, review, by FDA, procedure and panel selection;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5437&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Schick, A. L.;
T1 - Determination of fluoride in household products by ion selective electrode and Gran's plot
CT - Determination of fluoride in household products by ion selective electrode and Gran's plot
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/07/01/
VL - 56
IS - Jul
SP - 798
EP - 802
AD - Bureau of Product Safety, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4801; Language: English; Publication Type: Hazardous substances; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Fluorides--analysis--household products, use of ion selective electrode and Gran's plot;
KW - Analysis--fluorides--household products, use of ion selective electrode and Gran's plot;
KW - Toxicity, environmental--fluorides--analysis, in household products, use of ion selective electrode and Gran's plot;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4801&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
AU - Proctor, J. B.;
T1 - Effects of solvent composition on the partition of barbiturates
CT - Effects of solvent composition on the partition of barbiturates
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/07/01/
VL - 56
IS - Jul
SP - 864
EP - 868
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 10-4740; Language: English; Chemical Name: Secobarbital--76-73-3 Pentobarbital--76-74-4 Amobarbital--57-43-2 Butabarbital--125-40-6 Phenobarbital--50-06-6; References: 10; Journal Coden: JANCA2; Section Heading: Pharmaceutics
N2 - The distribution of 5 barbiturates between water and various mixed organic phases was studied in detail. It was shown that ether gave uniformly higher extraction constants than chloroform; dilution of these solvents with isooctane resulted in rapid, nonlinear decreases in extraction; these variations can be approximately described by an exponential equation. A uniform sequence of extractability was found, in decreasing order: secobarbital, pentobarbital, amobarbital, butabarbital, phenobarbital. Partition was independent of barbiturate concentration but varied with pH as expected by simple ionization considerations; these facts indicate that extraction of monomeric free barbiturate was the only important process. A large temperature effect was found for secobarbital. The results obtained are discussed in relation to the known partition chromatographic behavior of barbiturates.
KW - Secobarbital--extraction constants-;
KW - Pentobarbital--extraction constants-;
KW - Amobarbital--extraction constants-;
KW - Butabarbital--extraction constants-;
KW - Phenobarbital--extraction constants-;
KW - Barbiturates--solvents--composition, effects on partitioning;
KW - Solvents--barbiturates--effects, on partitioning;
KW - Partitioning--barbiturates--extraction constants, effects, solvent composition;
KW - Extraction constants--barbiturates--effects, solvent composition;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=10-4740&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Ruggles, D. I.;
T1 - Rabbit eye irritation test: collaborative study
CT - Rabbit eye irritation test: collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/07/01/
VL - 56
IS - Jul
SP - 905
EP - 914
AD - Division of Toxicology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-0154; Language: English; References: 6; Journal Coden: JANCA2; Section Heading: Methodology
N2 - The Draize rabbit eye irritation test was evaluated. Tests were conducted 2 at a time using 1 of 6 different materials with the same control substance (70% isopropyl alcohol), for a total of 12 tests. Test materials were selected with stringency, by employing compounds which were difficult to evaluate as they were neither strongly irritant nor innocuous. By the Draize procedure, 5 of these materials were considered irritants, and 2 nonirritants. Results showed that if all 4 criteria for eye irritation (changes in cornea and iris and conjuctival redness and chemosis) were employed, collaborators were quite consistent in separating an irritant from a nonirritant substance.
KW - Toxicity--tests--eyes, rabbit irritation, Draize test evaluated;
KW - Tests--Draize--eyes, rabbit irritation, evaluation;
KW - Chemicals--toxicity--tests, evaluation of Draize rabbit eye irritation test;
KW - Methodology--toxicity--tests, evaluation of Draize rabbit eye irritation test;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0154&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Baker, R. K.;
AU - Wallach, S.;
AU - Tashjian, A. H., Jr.;
T1 - Plasma calcitonin in pycnodysostosis: intermittently high basal levels and exaggerated responses to calcium and glucagon infusions
CT - Plasma calcitonin in pycnodysostosis: intermittently high basal levels and exaggerated responses to calcium and glucagon infusions
JO - J. Clin. Endocrinol. Metab.
JF - J. Clin. Endocrinol. Metab.
Y1 - 1973/07/01/
VL - 37
IS - Jul
SP - 46
EP - 55
AD - U. S. Public Health Service Clinical Research Center and Department of Medicine, Downstate Medical Center, Brooklyn, New York 11203
N1 - Accession Number: 11-2008; Language: English; Chemical Name: Calcium--7440-70-2 Glucagon--16941-32-5; Therapeutic Class: (68:20); AHFS Class: Antidiabetic agents glucagon; References: 27; Journal Coden: JCEMAZ; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - A case in which a child with osteoporotic bones, developmental abnormalities of the skeleton and clinical features of pycnodysostosis found to have high plasma levels of calcitonin (1.6 to 77 ng./ml.) in 33% of her basal fasting samples, and an exaggerated response of plasma calcitonin to infusions of calcium and glucagon is presented. It is not yet known whether the abnormality of calcitonin secretion is related etiologically to pycnodysostosis or whether it is a secondary feature of this rare disease.
KW - Calcium--adverse reactions-;
KW - Glucagon--adverse reactions-;
KW - Antidiabetic agents--glucagon--calcitonin, blood levels, increased, in child with pycnodysostosis;
KW - Drugs, adverse reactions--calcium--calcitonin, blood levels, increased, in child with pycnodysostosis;
KW - Drugs, adverse reactions--glucagon--calcitonin, blood levels, increased, in child with pycnodysostosis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2008&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Rader, B. R.;
T1 - Application of ion-pairing to separation of selected sulfonamides by partition chromatography
CT - Application of ion-pairing to separation of selected sulfonamides by partition chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/07/01/
VL - 62
IS - Jul
SP - 1148
EP - 1150
SN - 00223549
AD - Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Los Angeles, California 90015
N1 - Accession Number: 11-4038; Language: English; References: 15; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Methods are presented for the separation and determination of individual sulfonamides in mixtures. These procedures are based on the ion-pair formation of the sulfonamides with the tetrabutylammonium ion, followed by separation on partition chromatographic columns.
KW - Sulfonamides--chromatography--separation, by ion-pairing;
KW - Chromatography--sulfonamides--separation, by ion-pairing;
KW - Mixtures--sulfonamides--chromatography, separation by ion-pairing;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4038&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, E.;
AU - Barkan, S.;
AU - Ross, B.;
AU - Maienthal, M.;
AU - Levine, J.;
T1 - Examination of quinidine and quinine and their pharmaceutical preparations
CT - Examination of quinidine and quinine and their pharmaceutical preparations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/07/01/
VL - 62
IS - Jul
SP - 1151
EP - 1155
SN - 00223549
AD - Division of Drug Chemistry, Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Washington, D.C. 20204
N1 - Accession Number: 11-4039; Language: English; Chemical Name: Quinidine--56-54-2 Quinine--130-95-0; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs quinidine (8:20); AHFS Class: Plasmodicides quinine; References: 24; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Methods for the detection and measurement of possible contaminants in quinidine and quinine and their pharmaceutical preparations were investigated to establish the actual composition of quinidine and quinine now on the market. Dihydro analogs were found in all of the 75 samples examined, and desmethoxy analogs (cinchonine or cinchonidine) were found in about half of the samples. The level of dihydro alkaloids was higher in quinidine than in quinine (usually 5-9% in quinidine and 3-6% in quinine); the level of desmethoxy analogs was higher in quinine than in quinidine (usually 0-0.5% in quinidine compared to 1-2% in quinine). No epi-alkaloid, quininone, or quinotoxine was detected in any sample.
KW - Quinidine--analysis-;
KW - Quinine--analysis-;
KW - Cardiac drugs--quinidine--analysis, qualitative, contamination detection;
KW - Plasmodicides--quinine--analysis, qualitative, contamination detection;
KW - Analysis--quinidine--qualitative, contamination detection;
KW - Analysis--quinine--qualitative, contamination detection;
KW - Contamination--quinidine--analysis, qualitative;
KW - Contamination--quinine--analysis, qualitative;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Finkel, M. J.;
T1 - Instruction booklet and form for the IND: Instructions for submitting FD Form 1571, a notice of claimed investigational exemption for a new drug, by an individual physician investigator (investigational new drug application)
CT - Instruction booklet and form for the IND: Instructions for submitting FD Form 1571, a notice of claimed investigational exemption for a new drug, by an individual physician investigator (investigational new drug application)
JO - Psychopharmacol. Bull.
JF - Psychopharmacol. Bull.
Y1 - 1973/07/01/
VL - 9
IS - Jul
SP - 73
EP - 82
AD - Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 11-0948; Language: English; Journal Coden: PSYBB9; Section Heading: Methodology; Information Processing and Literature
N2 - An instruction booklet and revised form for submittal to the FDA of a Notice of Claimed Investigational Exemption for a New Drug (IND) was prepared for the use of individual investigators sponsoring their own ""Notice'' (as opposed to those performing investigations under a drug company sponsored ""Notice"). The purpose was to detail specific requirements for information to be submitted commensurate with the circumstances of the proposed clinical investigation.
KW - Drug information--investigational new drugs--forms, physicians, instructions;
KW - Drugs, investigational--investigational new drugs--forms, physicians, instructions;
KW - Physicians--investigational new drugs--forms, instructions;
KW - Clinical studies--investigational new drugs--forms, physicians, information;
KW - Forms--investigational new drugs--physicians, instructions;
KW - Regulations--investigational new drugs--forms, physicians, information;
KW - Methodology--investigational new drugs--forms, instructions for physicians;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2013-41574-001
AN - 2013-41574-001
AU - Schiele, Burtrum C.
AU - Gallant, Donald
AU - Simpson, George
AU - Gardner, Elmer A.
AU - Cole, Jonathan O.
T1 - Tardive dyskinesia.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1973/07//
VL - 43
IS - 4
SP - 506
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-41574-001. Partial author list: First Author & Affiliation: Schiele, Burtrum C.; American College of Neuropsychopharmacology, Food and Drug Administration Task Force, DC, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Letter. Language: English. Major Descriptor: Drug Dosages; Nervous System Disorders; Neuroleptic Drugs; Tardive Dyskinesia; Treatment Effectiveness Evaluation. Minor Descriptor: Drug Therapy. Classification: Neurological Disorders & Brain Damage (3297); Medical Treatment of Physical Illness (3363). Population: Human (10). Page Count: 2. Issue Publication Date: Jul, 1973.
AB - The syndrome is a persistent neurological disorder associated with antipsychotic drug use. When full-blown it is easily recognized, but early cases frequently are missed. Most patients who develop the syndrome have been on antipsychotic medication for a number of years, often at high dosage. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw. To make a definitive diagnosis of the syndrome, antipsychotic drugs must be discontinued. Then if the symptoms persist, the diagnosis is clear. No truly effective treatment for tardive dyskinesia is known. Discontinuing the presumably causal antipsychotic medication is indicated if at all possible. Certainly all classes of antipsychotic drugs are implicated. As far as is known, no individual drugs in extensive use have not been implicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antipsychotic drugs
KW - definitive neurological disorders
KW - tardive dyskinesia
KW - high dosages
KW - treatment effectiveness
KW - 1973
KW - Drug Dosages
KW - Nervous System Disorders
KW - Neuroleptic Drugs
KW - Tardive Dyskinesia
KW - Treatment Effectiveness Evaluation
KW - Drug Therapy
KW - 1973
DO - 10.1111/j.1939-0025.1973.tb00819.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1974-03559-001
AN - 1974-03559-001
AU - Shore, James H.
AU - Stone, Dennis L.
T1 - Duodenal ulcer among Northwest coastal Indian women.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1973/07//
VL - 130
IS - 7
SP - 774
EP - 777
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1974-03559-001. PMID: 4712729 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Shore, James H.; Portland Area Indian Health Service, Mental Health Office, Ore. Release Date: 19740201. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Acculturation; American Indians; Gastrointestinal Ulcers; Human Females; Psychological Stress. Classification: Psychological & Physical Disorders (3200); Social Processes & Social Issues (2900). Population: Human (10); Female (40). Page Count: 4. Issue Publication Date: Jul, 1973.
AB - Notes that Indian women from a Pacific Northwest coastal tribe are noted to have a high prevalence rate of duodenal ulcer, about 4 times greater than that for non-Indian women and above the rate of occurrence in Southwestern Indians. This high rate is analyzed in light of cultural heritage and current acculturation stresses. The historical role of Northwest Indian women in a matrilineal culture is discussed and the pressures on the Indian woman who lives in a minority-group-poverty-level community. (17 ref.) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cultural heritage & current acculturation stresses
KW - duodenal ulcer prevalence
KW - Northwest coastal Indian women
KW - 1973
KW - Acculturation
KW - American Indians
KW - Gastrointestinal Ulcers
KW - Human Females
KW - Psychological Stress
KW - 1973
DO - 10.1176/ajp.130.7.774
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1974-03559-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - WEINBERGER, MORRIS A.
T1 - The Blind Technique.
JO - Science
JF - Science
Y1 - 1973/07/20/
VL - 181
IS - 4096
M3 - Article
SP - 219
EP - 220
SN - 00368075
N1 - Accession Number: 85362861; WEINBERGER, MORRIS A. 1; Affiliations: 1: Division of Pathology, Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204; Issue Info: 7/20/1973, Vol. 181 Issue 4096, p219; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brodt, E. William
T1 - Urbanization and Health Planning: Challenge and Opportunity for the American Indian Community.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/08//
VL - 63
IS - 8
M3 - Article
SP - 694
EP - 701
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the issues related to urbanization and health planning in the American Indian Community. In the past decade, large segments of previously rural land have become urbanized through the mass migration of Americans to suburbia. Many communities are critically short of recreational space. Health facilities and services are frequently inadequate if they are available at all. Current trends toward support for Indian programs in education, housing. Health, and economic development provide an opportunity for Indian leaders to apply the experience gained from others' mistakes and bring about the best possible community development for the Indian people. The proposal to establish a health department indicates a desire for the formal planning structure. Land use must be recognized as a major factor influencing public health. In recent years, the ineffectiveness of water-quality management has become apparent with disturbing frequency. Maintaining the health of a population requires a well-organized preventive program. While most planning authorities verbally acknowledge the need for health care planning and environmental quality protection, their record of inaction is more revealing.
KW - Urbanization
KW - Public health
KW - Rural-urban migration
KW - Environmental quality
KW - Health planning
KW - Native Americans
KW - American
KW - Health
KW - Indian community
KW - Indian community, American
KW - Planning
N1 - Accession Number: 7971045; Brodt, E. William 1; Affiliations: 1: Operation Research Analyst, Department of Health, Education and Welfare, Public Health Service, Tucson.; Issue Info: Aug1973, Vol. 63 Issue 8, p694; Thesaurus Term: Urbanization; Thesaurus Term: Public health; Thesaurus Term: Rural-urban migration; Thesaurus Term: Environmental quality; Subject Term: Health planning; Subject Term: Native Americans; Author-Supplied Keyword: American; Author-Supplied Keyword: Health; Author-Supplied Keyword: Indian community; Author-Supplied Keyword: Indian community, American; Author-Supplied Keyword: Planning; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Novitch, M.;
T1 - Overmedication: international perspectives
CT - Overmedication: international perspectives
JO - Hosp. Formul. Manage.
JF - Hosp. Formul. Manage.
Y1 - 1973/08/01/
VL - 8
IS - Aug
SP - 16
EP - 20
AD - Food and Drug Administration, Public Health Service, Health, Education, and Welfare, Washington, D.C.
N1 - Accession Number: 11-0163; Language: English; References: 12; Journal Coden: HOFMAY; Section Heading: Sociology, Economics and Ethics; Pharmacy Practice; Abstract Author: Pamela N. Davis
N2 - The international problems of overmedication, and overuse and misuse of prescribed drugs are discussed. In 1969, 22 nations considered the problem of overmedication under the sponsorship of the WHO. In addition, proposals considered at the September 1973 Executive Board meeting of the WHO are listed. Many of the popular and acceptable means of promoting rational drug use are described, including the periodical journal, the formulary, controls on drug advertising to physicians, and formal review and control programs.
KW - Drug abuse--international--discussion;
KW - Rational therapy--international--promotion, means;
KW - World Health Organization--drug abuse--problems, discussion;
KW - Drug information--rational therapy--means for promoting;
KW - Journals--drug information--means of promoting rational therapy;
KW - Formularies--drug information--means for promoting rational therapy;
KW - Advertising--drugs--controls, to promote rational therapy;
KW - Control--advertising--to promote rational therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-08578-001
AN - 1974-08578-001
AU - Adam, W. R.
T1 - Novel diet preferences in potassium-deficient rats.
JF - Journal of Comparative and Physiological Psychology
JO - Journal of Comparative and Physiological Psychology
JA - J Comp Physiol Psychol
Y1 - 1973/08//
VL - 84
IS - 2
SP - 286
EP - 288
CY - US
PB - American Psychological Association
SN - 0021-9940
N1 - Accession Number: 1974-08578-001. PMID: 4723925 Other Journal Title: Journal of Animal Behavior; Journal of Comparative Psychology; Psychobiology. Partial author list: First Author & Affiliation: Adam, W. R.; U. Washington, U.S. Public Health Service Hosp. Other Publishers: Henry Holt and Company, Inc.; Williams & Wilkins Company. Release Date: 19740101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Feeding Behavior; Food Preferences; Potassium; Stimulus Novelty. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). References Available: Y. Page Count: 3. Issue Publication Date: Aug, 1973. Copyright Statement: American Psychological Association. 1973.
AB - Gave 29 potassium-deficient and 6 non-deficient Sprague-Dawley rats a choice of a familiar diet and 2 novel diets. Potassium depletion produced a preference for novel diets similar to that seen with vitamin and other deficiencies which was not overcome by the presence or absence of KCl or NaCl in the diets. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - potassium deficiency
KW - preference for familiar vs novel diet
KW - rats
KW - 1973
KW - Animal Feeding Behavior
KW - Food Preferences
KW - Potassium
KW - Stimulus Novelty
KW - Rats
KW - 1973
DO - 10.1037/h0035274
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1974-08578-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Levy, L.;
AU - Fasal, P.;
AU - Levan, N. E.;
AU - Freedman, R. I.;
T1 - Treatment of erythema nodosum leprosum with thalidomide
CT - Treatment of erythema nodosum leprosum with thalidomide
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1973/08/11/
VL - 2
IS - Aug 11
SP - 324
EP - 325
SN - 00237507
AD - U.S. Public Health Service Hospital, San Francisco, California 94118
N1 - Accession Number: 11-1026; Language: English; Chemical Name: Thalidomide--50-35-1; References: 2; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Investigational Drugs; Abstract Author: Joan Lentine
N2 - Results of preliminary studies on the use of thalidomide in low dosage for the long-term ambulatory management of patients with erythema nodosum leprosum (ENL) are reported. Of the 22 patients in this study, 16 had been receiving adrenal corticosteroids for long periods with only partial suppression of their disabling symptoms. Steroids were gradually withdrawn after thalidomide was begun. In all but 2 patients, thalidomide dosage has not exceeded 100 mg. at bedtime. None of the 16 patients initially on steroids were free of ENL despite dosages sufficient to produce varying degrees of hypercortisonism. Within a week of initiation of thalidomide therapy, the severity of the ENL was greatly diminished in all patients; they became afebrile and free of pain, and the nodose cutaneous lesions regressed rapidly. At present, all but 2 of the patients continue symptom free on a daily dosage of 100 mg. of thalidomide, without supplemental steroids. No serious side effects attributable to thalidomide during more than 350 patients months of observation have been reported. Particularly, no cases of thalidomide neuropathy have been observed. The only frequent complaint has been that of sedation, which has been overcome by giving the drug at bedtime.
KW - Thalidomide--erythema nodosum leprosum-;
KW - Erythema nodosum leprosum--thalidomide--therapy, in patients;
KW - Dosage--thalidomide--low, erythema nodosum leprosum, therapy, in patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Millar, David B.
AU - Grafius, Melba A.
AU - Palmer, David A.
AU - Millar, Geraldine
T1 - Enzymatically Active Half-Monomers of Acetyleholiesterase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1973/08/15/
VL - 37
IS - 3
M3 - Article
SP - 425
EP - 433
SN - 00142956
AB - An enzymatically active 7.4-S species of acetylcholinesterase has been isolated which has a molecular weight of 134000 ± 6%. It apparently has its origin in a Triton-X-100-mediated cleavage of higher polymers of acetylcholinesterase but not from cleavage of purified 10.8-S enzyme. The half-monomer has a Km for acetylthiocholine almost twice that of 10.8-S enzyme but the K1 for eserine is the same. The subunit molecular weight of the 7.4-S enzyme, as determined by sodium dodecylsulfate gel electrophoresis, is about 65000 indicating the enzyme to be a dimer. The enzyme is maximally heat stable in 0.1 M ammonium sulfate. Under certain conditions we observe a speed dependency of the sedimentation coefficient. These properties may make the half-monomer a useful model for studying the kinetics and subunit interactions in acetylcholinesterase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETYLCHOLINESTERASE
KW - CHOLINESTERASES
KW - ENZYMES
KW - PROTEINS
KW - POLYMERS
KW - MONOMERS
N1 - Accession Number: 13656713; Millar, David B. 1; Grafius, Melba A. 1; Palmer, David A. 1; Millar, Geraldine 2; Source Information: 1973, Vol. 37 Issue 3, p425; Subject: ACETYLCHOLINESTERASE; Subject: CHOLINESTERASES; Subject: ENZYMES; Subject: PROTEINS; Subject: POLYMERS; Subject: MONOMERS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - EPPLEY, ROBERT M.
AU - BAILEY, WILLIAM J.
T1 - 12,13-Epoxy-Δ9-Trichothecenes as the Probable Mycotoxins Responsible for Stachybotryotoxicosis.
JO - Science
JF - Science
Y1 - 1973/08/24/
VL - 181
IS - 4101
M3 - Article
SP - 758
EP - 760
SN - 00368075
AB - Stachybotrys atra cultures grown on oats produced five compounds toxic to brine shrimp; three are the sesquiterpenoid mycotoxins known as 12,13-epoxy-Δ9-trichothecenes. One trichothecene is roridin E, a known metabolite of Myrothecium verrucaria. The other two were hydrolyzed to verrucarol, the product of roridin and verrucarin hydrolysis. Spectroscopic data indicate that the two remaining compounds are also 12,13-epoxy-Δ9-trichothecenes. These metabolites are probably among those responsible for stachybotryotoxicosis [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85363104; EPPLEY, ROBERT M. 1; BAILEY, WILLIAM J. 2; Affiliations: 1: Division of Chemistry and Physics, Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Washington, D.C. 20204; 2: Department of Chemistry, University of Maryland, College Park 20742; Issue Info: 8/24/1973, Vol. 181 Issue 4101, p758; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steinman, Robert M.
AU - Haddad, Genevieve M.
AU - Skavenski, Alexander A.
AU - Wyman, Diane
T1 - Miniature Eye Movement.
JO - Science
JF - Science
Y1 - 1973/08/31/
VL - 181
IS - 4102
M3 - Article
SP - 810
EP - 819
SN - 00368075
N1 - Accession Number: 85117201; Steinman, Robert M. 1; Haddad, Genevieve M. 2; Skavenski, Alexander A. 3; Wyman, Diane 4; Affiliations: 1: Professor of psychology, University of Maryland, College Park 20742; 2: Research associate, Department of Psychology, University of Maryland; 3: Assistant professor, psychology, Northcastern University, Boston, Massachusetts 02115; 4: U.S. Public Health Service postdoctoral fellow, Department of Ophthalmology, George Washington University Medical Center, Washington, D.C. 20037; Issue Info: 8/31/1973, Vol. 181 Issue 4102, p810; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Rhododendron ingestion
CT - Rhododendron ingestion
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1973/09/01/
VL - Pages
IS - Sep-Oct
SP - 1
EP - 2
AD - Food and Drug Administration, Bureau of Drugs, 5401 Westbard Avenue, Bethesda, Maryland 20016
N1 - Accession Number: 11-2925; Language: English; Chemical Name: Atropine--51-55-8; References: 3; Journal Coden: NCPBBY; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Douglas L. Thompson
N2 - Gastric lavage and S.C. atropine 0.01 mg./kg. were used to successfully treat a 4-year-old male child who had ingested an unknown amount of rhododendron leaves and flowers.
KW - Atropine--antidotes-;
KW - Poisoning--rhododendron--therapy, successful with atropine and gastric lavage, in child;
KW - Rhododendron--poisoning--therapy, successful, with atropine and gastric lavage, in child;
KW - Plants--rhododendron--poisoning, successful therapy with atropine and gastric lavage, in child;
KW - Antidotes--atropine--rhododendron, poisoning, successful therapy with gastric lavage, in child;
KW - Toxicity--rhododendron--antidotes, atropine and gastric lavage, in child;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2925&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hopkins, H. C.;
T1 - Getting a handle on methadone
CT - Getting a handle on methadone
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1973/09/01/
VL - 7
IS - Sep
SP - 5
EP - 9
SN - 03621332
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 12-1693; Language: English; Chemical Name: Methadone--76-99-3; Journal Coden: FDACBH; Human Indicator: Yes; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - Recent changes in regulations governing the use of methadone in addicts are presented.
KW - Methadone--regulations-;
KW - Regulations--methadone--changes, regarding use in dependent patients;
KW - Dependence--narcotics--regulations, changes regarding methadone use in patients;
KW - Narcotics--dependence--regulations, changes regarding methadone use in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1693&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wiley, J. P., Jr.;
T1 - What's holding up new drug development?
CT - What's holding up new drug development?
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1973/09/01/
VL - 7
IS - Sep
SP - 21
EP - 24
SN - 03621332
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 12-1694; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - The reasons for the decrease in the number of new drug applications approved by the Food and Drug Administration are discussed.
KW - Drugs, investigational--new drug applications--decrease, FDA approvals, discussion;
KW - Food and Drug Administration (U.S.)--drugs, investigational--new drug applications, decrease in approvals, discussion;
KW - Regulations--drugs, investigational--new drug applications, decrease in FDA approvals, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1694&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Morris, W. W.;
T1 - High resolution infrared spectra of fragrance and flavor compounds
CT - High resolution infrared spectra of fragrance and flavor compounds
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/09/01/
VL - 56
IS - Sep
SP - 1037
EP - 1064
AD - Division of Colors and Cosmetics Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-0895; Language: English; Journal Coden: JANCA2; Section Heading: Pharmaceutical Chemistry
N2 - High resolution infrared spectra in the region from 4000 to 300 cm.\SU/\-/1\BS/ are presented for 99 fragrance and flavor compounds. These compounds were isolated from commercial and natural sources and were purified by preparative gas-liquid chromatography. Nuclear magnetic resonance analysis was utilized in many cases for verification of structure. The 4 strongest ir bands in the 1100-300 cm\SU/\-/1\BS/ region are also tabulated.
KW - Spectrometry, infrared--flavors--high resolution, spectra;
KW - Flavors--spectrometry, infrared--high resolution, spectra;
KW - Perfumes--spectrometry, infrared--high resolution, spectra;
KW - Spectrometry, infrared--perfumes--high resolution, spectra;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-0895&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - James, T.;
T1 - Individual tablet analysis for codeine and caffeine in codeine-aspirin-phenacetin-caffeine tablets
CT - Individual tablet analysis for codeine and caffeine in codeine-aspirin-phenacetin-caffeine tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/09/01/
VL - 62
IS - Sep
SP - 1500
EP - 1502
SN - 00223549
AD - Food and Drug Administration, Department of Health, Education and Welfare, Los Angeles, California 90015
N1 - Accession Number: 11-4990; Language: English; Chemical Name: Codeine--6059-47-8 Caffeine--58-08-2; References: 12; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Codeine is determined fluorometrically after extraction into dilute sulfuric acid; caffeine is extracted from a chloroform solution of the remaining ingredients with phosphoric acid and determined by UV spectroscopy. Average recoveries with a synthetic mixture were 99.7 and 98.9% for codeine and caffeine, respectively. The proposed procedure is compared with official methods.
KW - Codeine--fluorometry-;
KW - Caffeine--spectrometry, ultraviolet-;
KW - Fluorometry--codeine--in APC and codeine tablets;
KW - Spectrometry, ultraviolet--caffeine--in APC and codeine tablets;
KW - Tablets--codeine--fluorometry, in APC and codeine;
KW - Tablets--caffeine--spectrometry, ultraviolet, in APC and codeine;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4990&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Overton, M. W.;
AU - Alber, L. L.;
AU - Valentine, R. S.;
T1 - Semiautomated UV analysis of caffeine in aspirin-phenacetin-caffeine tablets
CT - Semiautomated UV analysis of caffeine in aspirin-phenacetin-caffeine tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/09/01/
VL - 62
IS - Sep
SP - 1524
EP - 1527
SN - 00223549
AD - Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Chicago, Illinois 60607
N1 - Accession Number: 11-4993; Language: English; Chemical Name: Caffeine--58-08-2 Aspirin--50-78-2 Phenacetin--62-44-2; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Caffeine--spectrometry, ultraviolet-;
KW - Aspirin--combination, caffeine, phenacetin-;
KW - Phenacetin--combination, aspirin, caffeine-;
KW - Spectrometry, ultraviolet--caffeine--semiautomated, in APC tablets;
KW - Tablets--caffeine--spectrometry, UV semiautomated, in APC tablets;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4993&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wyll, S. A.;
AU - Herrmann, K. L.;
T1 - Inadvertent rubella vaccination of pregnant women: fetal risk in 215 cases
CT - Inadvertent rubella vaccination of pregnant women: fetal risk in 215 cases
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/09/17/
VL - 225
IS - Sep 17
SP - 1472
EP - 1476
AD - Center for Disease Control, Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 11-1235; Language: English; References: 15; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity
N2 - Inadvertent rubella vaccination in early pregnancy or shortly before conception was studied in 215 cases to determine the risk of fetal infection with rubella vaccine-like virus (RVV). Of the 215 women, 184 (86%) did not have prevaccination sero-immunity screening. Only 24 women (11%) were known to be susceptible prior to vaccination. One hundred seven (50%) of the pregnancies ended with induced abortions, 12 (5%) with spontaneous abortions, and 96 (45%) with live births. None of the live-born infants had serologic or clinical evidence of congenital rubella; however, RVV was isolated from abortion specimens in 7 cases, 3 of which had isolates from fetal tissue. The similarities between RVV and wild rubella virus infection of decidual, placental, and fetal tissue strongly suggest that RVV poses a definite hazard to the fetus.
KW - Rubella vaccines--teratogenicity-;
KW - Teratogenicity--rubella vaccines--studies, following preconception or early pregnancy administration, in patients;
KW - Toxicity--rubella vaccines--teratogenicity, studies, following preconception or early pregnancy administration, in patients;
KW - Placental transfer--rubella vaccines--teratogenicity, studies, following preconception or early pregnancy administration, in patients;
KW - Metabolism--rubella vaccines--placental transfer, teratogenicity, studies, following preconception or early pregnancy administration, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1235&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Chapman, Larry S.
T1 - The Neighborhood Health Center Foundation for Health Care: A Portend for the Future or a Necessity for Survival?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/10//
VL - 63
IS - 10
M3 - Article
SP - 841
EP - 845
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the development of neighborhood health center approach to health care delivery in the U.S. The neighborhood health centers have proliferated under a variety of federal grant-in-aid programs and private sources of support. It was mentioned that neighborhood health center approach demands an increasing emphasis on cost-effective management of neighborhood health centers and increased revenue generation activities. In addition, changes in federal health service funding policies have necessitated a reevaluation of sources of future support for neighborhood health centers.
KW - Public health
KW - Community health services
KW - Medical care
KW - Community support
KW - Medical centers
KW - Health funding
KW - Health care reform
KW - Medical policy
KW - United States
KW - Care, health
KW - Health center, neighborhood
N1 - Accession Number: 7971066; Chapman, Larry S. 1; Affiliations: 1: Special Assistant, Regional Health Director for Technical Assistance, Department of Health, Education and Welfare, Public Health Service, Health Services and Mental Health Administration, Office of Planning and Evaluation, John Fitzgerald Kennedy Federal Building, Government Center, Region I, Boston, Massachusetts 02203; Issue Info: Oct1973, Vol. 63 Issue 10, p841; Thesaurus Term: Public health; Subject Term: Community health services; Subject Term: Medical care; Subject Term: Community support; Subject Term: Medical centers; Subject Term: Health funding; Subject Term: Health care reform; Subject Term: Medical policy; Subject: United States; Author-Supplied Keyword: Care, health; Author-Supplied Keyword: Health center, neighborhood; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=7971066&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Janssen, W. F.;
T1 - Toward a new era in consumer protection: Supreme Court rulings on drug effectiveness
CT - Toward a new era in consumer protection: Supreme Court rulings on drug effectiveness
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1973/10/01/
VL - 7
IS - Oct
SP - 19
EP - 27
SN - 03621332
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20852
N1 - Accession Number: 12-1692; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and Ethics; Abstract Author: James B. Lumbard
N2 - Supreme court rulings from 1906 to 1973 and their implications to the health professions and the consumer are discussed.
KW - Laws--drugs, clinical effectiveness--consumer protection, supreme court rulings;
KW - Drugs, clinical effectiveness--laws--consumer protection, supreme court rulings;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1692&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bracey, A.;
T1 - Detection of ampicillin contamination in nitrofurantoin preparations by high pressure liquid chromatography
CT - Detection of ampicillin contamination in nitrofurantoin preparations by high pressure liquid chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/10/01/
VL - 62
IS - Oct
SP - 1695
EP - 1696
SN - 00223549
AD - National Center for Antibiotic Analysis, Food and Drug Administration, HEW, Washington, D.C. 20204
N1 - Accession Number: 12-2823; Language: English; Chemical Name: Ampicillin--69-53-4 Nitrofurantoin--67-20-9; References: 8; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Ampicillin contamination in nitrofurantoin capsules and tablets was determined by high pressure liquid chromatography. The method is quantitative over the range 1-10 mcg of ampicillin.
KW - Ampicillin--contamination-;
KW - Nitrofurantoin--dosage forms-;
KW - Contamination--ampicillin--nitrofurantoin, tablets and capsules, high pressure liquid chromatography;
KW - Tablets--nitrofurantoin--contamination, ampicillin, high pressure liquid chromatography;
KW - Capsules--nitrofurantoin--contamination, ampicillin, high pressure liquid chromatography;
KW - Chromatography, liquid--nitrofurantoin--dosage forms, high pressure, detection of ampicillin contamination;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2823&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Goldwitz, B. A.;
T1 - NMR Analysis of pharmaceuticals. 10. Determination of methsuximide and phensuximide in capsules
CT - NMR Analysis of pharmaceuticals. 10. Determination of methsuximide and phensuximide in capsules
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/10/01/
VL - 62
IS - Oct
SP - 1705
EP - 1707
SN - 00223549
AD - Food and Drug Administration, HEW, Brooklyn, New York 11232
N1 - Accession Number: 12-2825; Language: English; Chemical Name: Methsuximide--77-41-8 Phensuximide--86-34-0; Therapeutic Class: (28:12); AHFS Class: Anticonvulsants methsuximide (28:12); AHFS Class: Anticonvulsants phensuximide; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Methsuximide--spectrometry, nuclear magnetic resonance-;
KW - Phensuximide--spectrometry, nuclear magnetic resonance-;
KW - Capsules--methsuximide--spectrometry, nuclear magnetic resonance, quantitative;
KW - Capsules--phensuximide--spectrometry, nuclear magnetic resonance, quantitative;
KW - Spectrometry, nuclear magnetic resonance--methsuximide--capsules, quantitative;
KW - Spectrometry, nuclear magnetic resonance--phensuximide--capsules, quantitative;
KW - Anticonvulsants--methsuximide--capsules, quantitative, NMR spectrometry;
KW - Anticonvulsants--phensuximide--capsules, quantitative, NMR spectrometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2825&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, D. J.;
AU - Cook, D. G.;
T1 - Simultaneous semiautomated determination of pentaerythritol tetranitrate or mannitol hexanitrate and phenobarbital in tablets
CT - Simultaneous semiautomated determination of pentaerythritol tetranitrate or mannitol hexanitrate and phenobarbital in tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/10/01/
VL - 62
IS - Oct
SP - 1713
EP - 1717
SN - 00223549
AD - Detroit District, Food and Drug Administration, Detroit, Michigan 48207
N1 - Accession Number: 12-3488; Language: English; Chemical Name: Phenobarbital--50-06-6 Pentaerythritol tetranitrate--78-11-5 Mannitol--69-65-8; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics phenobarbital; References: 23; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - A combination of colorimetry and UV spectrometry for the simultaneous determination of pentaerythritol tetranitrate, mannitol hexanitrate and phenobarbital in single tablets is described. The organic nitrate esters are assayed by a colorimetric procedure involving the diazotization of p-chloroaniline with nitrate and coupling of the resultant compound with N-1-naphthylethylenediamine. Color intensity is measured at 570 nm for I and at 613 nm for II. Phenobarbital is determined by the UV absorption at 241 nm after extraction into chloroform followed by extraction into aqueous base. The effect of one component on the assay results of the other is reported.
KW - Phenobarbital--colorimetry-;
KW - Pentaerythritol tetranitrate--colorimetry-;
KW - Mannitol--hexanitrate-;
KW - Mannitol--and nitrates, tablets-;
KW - Tablets--phenobarbital--spectrometry, and colorimetry, simultaneous analysis with organic nitrate esters;
KW - Spectrometry, ultraviolet--phenobarbital--tablets, and colorimetry, simultaneous analysis with organic nitrate esters;
KW - Sedatives and hypnotics--phenobarbital--tablets, UV spectrometry and colorimetry, simultaneous analysis with organic nitrate esters;
KW - Colorimetry--nitrates--esters, organic, UV spectrometry and colorimetry, simultaneous analysis with phenobarbital in tablets;
KW - Colorimetry--phenobarbital;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3488&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Chirigos, M. A.;
AU - Pearson, J. W.;
T1 - Cure of murine leukemia with drug and interferon treatment
CT - Cure of murine leukemia with drug and interferon treatment
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1973/10/01/
VL - 51
IS - Oct
SP - 1367
EP - 1368
SN - 00278874
AD - Viral Leukemia and Lymphoma Branch, National Cancer Institute, NIH, Public Health Service, U. S. Department of Health Education and Welfare, Bethesda, Maryland
N1 - Accession Number: 11-1474; Language: English; Chemical Name: Interferon--9008-11-1; References: 13; Section Heading: Drug Interactions; Pharmacology
N2 - A discussion of the effects of interferon and drug therapy in the treatment of leukemia is presented. Interferon has limited in vivo antitumor activity when host tumor load is great. When systemic leukemia is arrested by drug therapy which leads to a reduction of tumor cells, subsequent treatment with interferon leads to a significant number of cures. The combined drug and interferon treatment exerts a synergistic antitumor effect.
KW - Interferon--interactions-;
KW - Antineoplastic agents--interactions--interferon, synergism, leukemia therapy;
KW - Drug interactions--interferon and antineoplastic agents--synergism, leukemia therapy;
KW - Drug interactions--antineoplastic agents and interferon--synergism, leukemia therapy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1474&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-11868-001
AN - 1974-11868-001
AU - Hammerschlag, Carl A.
AU - Alderfer, Clayton P.
AU - Berg, David
T1 - Indian education: A human systems analysis.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1973/10//
VL - 130
IS - 10
SP - 1098
EP - 1102
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1974-11868-001. PMID: 4728901 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Hammerschlag, Carl A.; Indian Health Service, Phoenix, Ariz. Release Date: 19740601. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Educational Programs; Government Programs. Classification: Educational Psychology (3500). Population: Human (10). Page Count: 5. Issue Publication Date: Oct, 1973.
AB - Examines the problems of American Indian boarding schools in the light of both systems theory and data from interviews and questionnaires conducted at 1 school. It is concluded that the schools have failed to define their primary task-to educate or to handle children with behavior problems. More importantly, the impact of the whole educational system perpetuates the Indians' powerlessness and dependency on the government. The hope is expressed that if there is more community involvement in the schools it will lead to greater assumption of responsibility by Indians in other spheres. (15 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perpetuation of powerlessness & dependency on government through educational system
KW - boarding schools
KW - American Indians
KW - 1973
KW - American Indians
KW - Educational Programs
KW - Government Programs
KW - 1973
DO - 10.1176/ajp.130.10.1098
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1974-11868-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Rossi, A. C.;
AU - Carnahan, H. D.;
AU - Desmond, C. T.;
T1 - FDA's Adverse Drug Reaction Reporting Program
CT - FDA's Adverse Drug Reaction Reporting Program
JO - Drug Therapy (USA)
JF - Drug Therapy (USA)
Y1 - 1973/11/01/
VL - 3
IS - Nov
SP - 31
EP - 34
SN - 10552952
AD - Food and Drug Administration, Division of Epidemiology & Drug Experience, Office of Scientific Coordinator, Bureau of Drugs, Rockville, Maryland
N1 - Accession Number: 11-3168; Language: English; Journal Coden: DRTHDZ; Section Heading: Information Processing and Literature; Abstract Author: Garf Thomas
N2 - The efforts of the Food and Drug Administration to increase physician reporting of adverse reactions are cited. The Adverse Drug Reaction Reporting Program is designed as a national focal point for accumulating drug experience information. Efforts have been made to simplify the procedure for adverse reaction reporting. The shortened reporting form is described. Simplification of procedures has led to a significant increase in private physician reports on adverse drug reactions.
KW - Food and Drug Administration (U.S.)--Adverse Drug Reaction Reporting Program--procedures, for reporting adverse drug effects;
KW - Drugs, adverse reactions--physicians--reports, procedures of FDA Adverse Drug Reaction Reporting Program;
KW - Physicians--adverse reactions--reports, procedures of FDA Adverse Drug Reaction Reporting Program;
KW - Forms--adverse reactions--reports, Adverse Drug Reaction Reporting Program, description;
KW - Drug information--adverse reactions--Adverse Drug Reaction Reporting Program, FDA, description;
KW - Adverse Drug Reaction Reporting Program--Food and Drug Administration (U.S.)--description;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3168&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fernandez-Flores, E.;
AU - Johnson, A. R.;
AU - Leber, B.;
AU - Larry, D.;
AU - Lerner, S.;
T1 - Colorimetric determination of saccharin in foods
CT - Colorimetric determination of saccharin in foods
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/11/01/
VL - 56
IS - Nov
SP - 1411
EP - 1414
AD - Division of Food Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 11-1533; Language: English; Chemical Name: Saccharin--81-07-2; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Saccharin--colorimetry-;
KW - Food--saccharin--colorimetry;
KW - Colorimetry--saccharin--in foods;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1533&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
AU - Graichen, C.;
T1 - Determination of FD&C Red No. 3 (erythrosine) in rat blood serum
CT - Determination of FD&C Red No. 3 (erythrosine) in rat blood serum
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/11/01/
VL - 56
IS - Nov
SP - 1458
EP - 1459
AD - Division of Colors and Cosmetics Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 11-1329; Language: English; Trade Name: FD*C Red No. 3; Generic Name: Erythrosine sodium; Chemical Name: Erythrosine sodium--16423-68-0; Journal Coden: JANCA2; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
KW - Erythrosine sodium--blood levels-;
KW - Erythrosine--blood levels-;
KW - Blood levels--erythrosine sodium--in rats;
KW - Metabolism--erythrosine sodium--blood levels, in rats;
KW - Dyes--erythrosine sodium--blood levels, in rats;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1329&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Determination of sulfaquinoxaline, sulfathiazole, sulfamerazine, and sulfamethazine in feed concentrates or premixes
CT - Determination of sulfaquinoxaline, sulfathiazole, sulfamerazine, and sulfamethazine in feed concentrates or premixes
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/11/01/
VL - 56
IS - Nov
SP - 1475
EP - 1479
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 11-1536; Language: English; Chemical Name: Sulfaquinoxaline--59-40-5 Sulfathiazole--72-14-0 Sulfamerazine--127-79-7 Sulfamethazine--57-68-1; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Sulfaquinoxaline is determined by its UV absorbance at about 358 nm. Sulfathiazole, sulfamerazine, and sulfamethazine are determined by a quantitative TLC procedure, based on the separation of the compounds on silica gel plates. A method of calculating the total sulfonamide content, independent of the individual components, is also introduced.
KW - Sulfaquinoxaline--combination, sulfathiazole, sulfamerazine, sulfamethazine-;
KW - Sulfathiazole--combination, sulfaquinoxaline, sulfamerazine, sulfamethazine-;
KW - Sulfamerazine--combination, sulfaquinoxaline, sulfathiazole, sulfamethazine-;
KW - Sulfamethazine--combination, sulfaquinoxaline, sulfamerazine, sulfathiazole-;
KW - Sulfonamides--feeds--analysis;
KW - Chromatography, thin layer--sulfonamides--and UV spectrometry, in feeds;
KW - Spectrometry, ultraviolet--sulfonamides--and TLC, in feeds;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1536&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jeffus, M. T.;
AU - Kenner, C. T.;
T1 - Spectrophotofluorometric estimation of low levels of diethylstilbestrol in feedstuffs
CT - Spectrophotofluorometric estimation of low levels of diethylstilbestrol in feedstuffs
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1973/11/01/
VL - 56
IS - Nov
SP - 1483
EP - 1488
AD - Food and Drug Administration, 3032 Bryan Street, Dallas, Texas 75204
N1 - Accession Number: 11-1751; Language: English; Chemical Name: Diethylstilbestrol--56-53-1; Therapeutic Class: (68:16); AHFS Class: Estrogens diethylstilbestrol; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Diethylstilbestrol--fluorometry-;
KW - Feeds--diethylstilbestrol--fluorometry;
KW - Fluorometry--diethylstilbestrol--feeds;
KW - Estrogens--diethylstilbestrol--fluorometry, feeds;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1751&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lockhart, J. D.;
T1 - Hexachlorophene and the Food and Drug Administration
CT - Hexachlorophene and the Food and Drug Administration
JO - J. Clin. Pharmacol. New Drugs
JF - J. Clin. Pharmacol. New Drugs
Y1 - 1973/11/01/
VL - 13
IS - Nov-Dec
SP - 445
EP - 450
AD - Bureau of Drugs, Food and Drug Administration, Rockville, Maryland [Reprints:]1801 Hinman Avenue, Evanston, Illinois 60204
N1 - Accession Number: 11-3427; Language: English; Chemical Name: Hexachlorophene--70-30-4; Therapeutic Class: (38:00); AHFS Class: Disinfectants hexachlorophene; References: 10; Journal Coden: JCPHB8; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - The chronological sequence of events leading to the FDA's decision in September 1972 to remove hexachlorophene from all over-the-counter drug and cosmetic products, except in preservative levels, is presented.
KW - Hexachlorophene--Food and Drug Administration (U.S.)-;
KW - Food and Drug Administration (U.S.)--hexachlorophene--drugs, over-the-counter, removal, factors affecting decision;
KW - Drugs, over-the-counter--hexachlorophene--removal, factors affecting FDA decision;
KW - Disinfectants--hexachlorophene--drugs, over-the-counter, removal, factors affecting FDA decision;
KW - Cosmetics--hexachlorophene--removal, factors affecting FDA decision;
KW - Regulations--hexachlorophene--drugs, over-the-counter, removal, factors affecting FDA decision;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3427&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
AU - Tsuji, K.;
T1 - Optimum conditions for GLC analysis of neomycin
CT - Optimum conditions for GLC analysis of neomycin
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/11/01/
VL - 62
IS - Nov
SP - 1836
EP - 1838
SN - 00223549
AD - National Center for Antibiotic Analysis, Food and Drug Administration, HEW, Washington, D. C. 20204
N1 - Accession Number: 12-1625; Language: English; Chemical Name: Neomycin--1404-04-2; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Neomycin--chromatography, gas-;
KW - Chromatography, gas--neomycin--optimum conditions;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1625&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Kenner, C. T.;
T1 - Acetonitrile-diatomaceous earth column for separation of steroids and other compounds
CT - Acetonitrile-diatomaceous earth column for separation of steroids and other compounds
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/11/01/
VL - 62
IS - Nov
SP - 1845
EP - 1849
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 12-1606; Language: English; Chemical Name: Acetonitrile--75-05-8; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
KW - Acetonitrile--and diatomaceous earth-;
KW - Chromatography, column--steroids--separation, acetonitrile-diatomaceous earth column;
KW - Steroids--chromatography, column--separation, acetonitrile-diatomaceous earth column;
KW - Diatomaceous earth--and acetonitrile--chromatography, column, steroid separation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Josephson, M. E.;
AU - Caracta, A. R.;
AU - Lau, S. H.;
AU - Gallagher, J. J.;
AU - Damato, A. N.;
T1 - Electrophysiological evaluation of disopyramide in man
CT - Electrophysiological evaluation of disopyramide in man
JO - Am. Heart J.
JF - Am. Heart J.
Y1 - 1973/12/01/
VL - 86
IS - Dec
SP - 771
EP - 780
AD - Cardiopulmonary Laboratory, United States Public Health Service Hospital, Staten Island, New York 10304
N1 - Accession Number: 11-3098; Language: English; Chemical Name: Disopyramide--3737-09-5; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs disopyramide; References: 19; Journal Coden: AHJOA2; Human Indicator: Yes; Section Heading: Pharmacology; Investigational Drugs; Abstract Author: F. James Grogan
N2 - A discussion of the electrophysiological effects of disopyramide in man is presented. Disopyramide shares many clinical properties with quinidine even though its chemical structure is very different. It does not depress atrio-ventricular node and His-Purkinje conduction like procainamide and quinidine and might therefore be indicated in the treatment of arrhythmias which are associated with some degree of atrioventricular block. Disopyramide I.V. has a relatively rapid onset of action and a half-life of 1.4 to 2 hours.
KW - Disopyramide--arrhythmias-;
KW - Cardiac drugs--disopyramide--arrhythmias, mechanism of action, in patients;
KW - Half-life--disopyramide--injections, I.V., in patients;
KW - Mechanism of action--disopyramide--arrythmias, therapy, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3098&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Messer, James W.
AU - Lesile, James E.
AU - Brown, David F.
AU - Peeler, James T.
AU - Green, Marvin T.
AU - Wimsatt, John C.
AU - Gilchrist, James E.
T1 - A Comparative Quality Survey of Five Common Market Foods in Low and High Income Economic Areas.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1973/12//
VL - 63
IS - 12
M3 - Article
SP - 1074
EP - 1079
PB - American Public Health Association
SN - 00900036
AB - A study is reported based on analyses of food samples gathered from five retail stores in each of two communities from June through August 1968. Market microbiological food quality was determined by the presence of disease- and illness-producing organisms. Chemical food quality was also studied. In terms of selected criteria no significant differences between lower and higher economic areas were found. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Retail stores
KW - Food science
KW - Retail industry
KW - Commerce
KW - Marketing
KW - Food -- Quality
KW - Quality
KW - Dinners & dining
KW - Home economics
N1 - Accession Number: 7971080; Messer, James W. 1; Lesile, James E. 1; Brown, David F. 1; Peeler, James T. 2; Green, Marvin T. 2; Wimsatt, John C. 3; Gilchrist, James E. 3; Affiliations: 1: Microbiologist, Food and Drug Administration, 1090 TuscuIum Avenue, Cincinnati, Ohio 45226; 2: Biological Laboratory Aid, 1090 TuscuIum Avenue, Cincinnati, Ohio 45226; 3: Chemists, Food and Drug Administration, 1090 TuscuIum Avenue, Cincinnati, Ohio 45226; Issue Info: Dec1973, Vol. 63 Issue 12, p1074; Thesaurus Term: Retail stores; Thesaurus Term: Food science; Subject Term: Retail industry; Subject Term: Commerce; Subject Term: Marketing; Subject Term: Food -- Quality; Subject Term: Quality; Subject Term: Dinners & dining; Subject Term: Home economics; NAICS/Industry Codes: 541613 Marketing Consulting Services; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 452999 All other miscellaneous general merchandise stores; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Sherken, S.;
AU - Friedman, E. J.;
T1 - Quantitative determination of bismuth trioxide in Teflon catheters using decomposition by molten salt fusion followed by standard addition and conventional direct current polarography
CT - Quantitative determination of bismuth trioxide in Teflon catheters using decomposition by molten salt fusion followed by standard addition and conventional direct current polarography
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1973/12/01/
VL - 45
IS - Dec
SP - 2399
EP - 2400
AD - Department of Health, Education and Welfare, Food and Drug Administration, 850 Third Avenue, Brooklyn, New York 11232
N1 - Accession Number: 11-1920; Language: English; Publication Type: Notes; Journal Coden: ANCHAM; Section Heading: Drug Analysis
KW - Bismuth trioxide--analysis-;
KW - Catheters--radiopaque--analysis, bismuth trioxide;
KW - Analysis--bismuth trioxide--in radiopaque Teflon catheters;
KW - Polarography--bismuth trioxide--in radiopaque Teflon catheters;
KW - Surgical supplies--catheters--radiopaque, Teflon, bismuth trioxide analysis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1920&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Olson, M. C.;
T1 - Analysis of adrenocortical steroids (hydrocortisone, cortisone and acetates) in pharmaceutical preparations by high pressure liquid-liquid chromatography
CT - Analysis of adrenocortical steroids (hydrocortisone, cortisone and acetates) in pharmaceutical preparations by high pressure liquid-liquid chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/12/01/
VL - 62
IS - Dec
SP - 2001
EP - 2007
SN - 00223549
AD - Food and Drug Administration, HEW, Brooklyn, New York 11232
N1 - Accession Number: 12-1345; Language: English; Chemical Name: Hydrocortisone--50-23-7 Cortisone--53-06-5; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Hydrocortisone--chromatography, liquid-;
KW - Cortisone--chromatography, liquid-;
KW - Steroids, cortico---chromatography, liquid--high pressure, dosage forms;
KW - Dosage forms--steroids, cortico---chromatography, liquid, high pressure;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1345&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Salt, D. T.;
AU - Arret, B.;
AU - Wilner, J.;
T1 - Low temperature maintenance of test organism suspensions for antibiotic assays
CT - Low temperature maintenance of test organism suspensions for antibiotic assays
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1973/12/01/
VL - 62
IS - Dec
SP - 2040
EP - 2043
SN - 00223549
AD - National Center for Antibiotic Analysis, Food and Drug Administration, HEW, Washington, D.C. 20204
N1 - Accession Number: 12-1377; Language: English; Publication Type: Notes; Journal Coden: JPMSAE; Section Heading: Microbiology
KW - Suspensions--bacteria--stability, low temperature maintenance of test organism for antibiotic assays;
KW - Antibiotics--analysis--microbiological, low temperature maintenance of test organism suspensions;
KW - Analysis--antibiotics--microbiological, low temperature maintenance of test organism suspensions;
KW - Stability--suspensions--bacteria, low temperature maintenance of test organism for antibiotic assays;
KW - Bacteria--suspensions--stability, low temperature maintenance of test organisms for antibiotic assays;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1377&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Winkler, W. G.;
AU - Fashinell, T. R.;
AU - Leffingwell, L.;
AU - Howard, P.;
AU - Conomy, J. P.;
T1 - Airborne rabies transmission in a laboratory worker
CT - Airborne rabies transmission in a laboratory worker
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1973/12/03/
VL - 226
IS - Dec 3
SP - 1219
EP - 1221
AD - Rabies Control Unit, Viral Diseases Branch, Epidemiology Program, Center for Disease Control, Public Health Service, P.O. Box 363, Lawrenceville, Georgia 30245
N1 - Accession Number: 11-2803; Language: English; References: 11; Publication Type: Brief Reports; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - A 56-year-old man died of rabies 21 days after exposure to a ""fixed'' strain of rabies virus, which apparently resulted from inhalation of an aerosol generated in a biological laboratory during the manufacture of animal rabies vaccine. Rabies virus was recovered from the brain by cultural techniques and demonstrated in neural tissue by electron microscopy. The victim had received preexposure vaccination against rabies 13 years earlier but had not developed demonstrable serum antibodies.
KW - Rabies vaccines--toxicity, environmental-;
KW - Toxicity, environmental--rabies vaccines--rabies, fatal, following inhalation during manufacture, in patient;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2803&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - ELDER, ROBERT L.
T1 - Lasers and Eye Protection.
JO - Science
JF - Science
Y1 - 1973/12/14/
VL - 182
IS - 4117
M3 - Article
SP - 1080
EP - 1080
SN - 00368075
N1 - Accession Number: 85178818; ELDER, ROBERT L. 1; Affiliations: 1: Bureau of Radiological Health, Food and Drug Administration, Rockville, Maryland 20852; Issue Info: 12/14/1973, Vol. 182 Issue 4117, p1080; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Josephson, M. E.;
AU - Seides, S. F.;
AU - Batsford, W. P.;
AU - Weisfogel, G. M.;
AU - Akhtar, M.;
AU - \ET/;
T1 - Electrophysiological effects of intramuscular quinidine on the atrioventricular conducting system in man
CT - Electrophysiological effects of intramuscular quinidine on the atrioventricular conducting system in man
JO - Am. Heart J.
JF - Am. Heart J.
Y1 - 1974/01/01/
VL - 87
IS - Jan
SP - 55
EP - 64
AD - Cardiopulmonary Laboratory, United States Public Health Service Hospital, Staten Island, New York 10304
N1 - Accession Number: 12-1000; Language: English; Chemical Name: Quinidine--56-54-2; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs quinidine; References: 50; Journal Coden: AHJOA2; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: F. James Grogan
N2 - A study to evaluate the effects of I.M. quinidine gluconate on the electrophysical properties of the atrioventricular (AV) conducting system in man using His bundle electrograms is presented. Quinidine tends to shorten AV nodal conduction time while it routinely prolongs His-Purkinje and intraventricular conduction time. The refractory periods of the atrium and His-Purkinje system were prolonged by quinidine while the effective refractory period of the AV node was consistently shortened. These studies suggest quinidine has antivagal properties which are of clinical significance.
KW - Quinidine--mechanism of action-;
KW - Mechanism of action--quinidine--effects, atrioventricular conducting system, in humans;
KW - Cardiac drugs--quinidine--effects, atrioventricular conducting system, in humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1000&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Flinn, P. E.;
AU - Smith, T. G.;
T1 - Thin layer chromatographic quantitative analysis of polythiazide tablets
CT - Thin layer chromatographic quantitative analysis of polythiazide tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/01/01/
VL - 57
IS - Jan
SP - 82
EP - 84
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
N1 - Accession Number: 11-2763; Language: English; Chemical Name: Polythiazide--346-18-9; Therapeutic Class: (40:28); AHFS Class: Diuretics polythiazide; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Polythiazide--chromatography, thin layer-;
KW - Diuretics--polythiazide--chromatography, thin layer, quantitative, tablets;
KW - Chromatography, thin layer--polythiazide--tablets, quantitative;
KW - Tablets--polythiazide--chromatography, thin layer, quantitative;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-2763&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haley, T. J.;
AU - Hunziker, J.;
T1 - Instrument for producing standardized skin abrasions
CT - Instrument for producing standardized skin abrasions
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/01/01/
VL - 63
IS - Jan
SP - 106
SN - 00223549
AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079
N1 - Accession Number: 12-4806; Language: English; References: 3; Journal Coden: JPMSAE; Section Heading: Methodology
N2 - An instrument is described which will produce a standardized skin abrasion in the Draize test for skin irritants. The same degree of abrasion without bleeding can be produced on each application.
KW - Methodology--skin--abrasions, instrument for producing standardized abrasions;
KW - Skin--abrasions--methodology, instrument for producing standardized abrasions;
KW - Equipment--abrasions--skin, standardized, description of instrument;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-21382-001
AN - 1974-21382-001
AU - Walker, Frances
T1 - Bridging a cultural gap for better patient care.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 1974/01//
VL - 139
IS - 1
SP - 26
EP - 29
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
N1 - Accession Number: 1974-21382-001. PMID: 4204917 Partial author list: First Author & Affiliation: Walker, Frances; Indian Health Service Hosp., Rapid City, S.D. Release Date: 19740701. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Attitudes; Cross Cultural Differences; Medical Personnel; Medical Treatment (General). Classification: Health & Mental Health Treatment & Prevention (3300); Social Processes & Social Issues (2900). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1974.
AB - Considers that deliverance of uninterrupted health care to the Navajo people depends greatly on the comprehension of cultural differences by the non-Indian medical team and on its acceptance of and compliance with the Navajo customs. The Navajo concept of complete health care is a combining of the care given by the medicine man and the treatment provided by the medical physician. To secure cooperation of the Navajo patients and their families, and increase their understanding of the methods and goals of treatment, this medical team must provide good patient teaching, along with the nonjudgmental acceptance of the Indians' cultural beliefs. A 3-way plan to bridge the cultural gap in the 2 systems is presented. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - comprehension & nonjudgmental acceptance of Navajo customs & cultural differences
KW - effective patient care by non-Indian medical teams
KW - Navajo Indians
KW - 1974
KW - American Indians
KW - Attitudes
KW - Cross Cultural Differences
KW - Medical Personnel
KW - Medical Treatment (General)
KW - 1974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1974-21382-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-41576-006
AN - 2013-41576-006
AU - Dizmang, Larry H.
AU - Watson, Jane
AU - May, Philip A.
AU - Bopp, John
T1 - Adolescent suicide at an Indian reservation.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1974/01//
VL - 44
IS - 1
SP - 43
EP - 49
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - May, Philip A., Rural Route #1, Florence, MT, US, 59833
N1 - Accession Number: 2013-41576-006. PMID: 4809584 Partial author list: First Author & Affiliation: Dizmang, Larry H.; Private Practice, Annapolis, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Meeting of the American Psychiatric Association, May, 1970. Conference Note: Presented in a similar version at the aforementioned conference. Major Descriptor: Developmental Age Groups; Experiment Controls; Prevention; Suicide. Minor Descriptor: American Indians; Tribes. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 1974.
AB - The backgrounds of ten American Indians who committed suicide before the age of twenty-five are compared statistically with a matched control group from the same tribe. The contrast is significant in at least six variables that point to the greater individual and familial disruption experienced by the suicidal youths. Suggestions for treatment and prevention based on the experience of this tribe are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent suicide
KW - Indian reservation
KW - suicidal youths
KW - prevention
KW - control group
KW - tribes
KW - 1974
KW - Developmental Age Groups
KW - Experiment Controls
KW - Prevention
KW - Suicide
KW - American Indians
KW - Tribes
KW - 1974
DO - 10.1111/j.1939-0025.1974.tb00867.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-41576-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1975-07650-001
AN - 1975-07650-001
AU - Colon, P. G.
T1 - The effects of heroin addiction on teeth.
JF - Journal of Psychedelic Drugs
JO - Journal of Psychedelic Drugs
JA - J Psychedelic Drugs
Y1 - 1974/01//
VL - 6
IS - 1
SP - 57
EP - 60
CY - US
PB - Haight-Ashbury Publications
SN - 0022-393X
N1 - Accession Number: 1975-07650-001. Other Journal Title: Journal of Psychoactive Drugs. Partial author list: First Author & Affiliation: Colon, P. G.; US Public Health Service, Federal Corrections Inst, San Pedero, CA. Other Publishers: Taylor & Francis. Release Date: 19750401. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Dentistry; Heroin Addiction. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 4. Issue Publication Date: Jan, 1974.
AB - Describes the impact of heroin addiction on oral health. Heroin withdrawal is related to the occurrence of necrotizing ulcerative gingivitis (trench mouth). The high incidence of dental disease noted in a review of the medical records of 322 addicts is attributed to local environmental factors coupled with systemic effects of heroin, rather than to the drug itself. (16 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - heroin addiction
KW - dental disease
KW - 1974
KW - Dentistry
KW - Heroin Addiction
KW - 1974
DO - 10.1080/02791072.1974.10471505
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1975-07650-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Hamet, S. H.;
AU - Brennan, E. C.;
T1 - Analysis of theophylline elixir
CT - Analysis of theophylline elixir
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1974/02/01/
VL - 31
IS - Feb
SP - 167
EP - 170
SN - 00029289
AD - Quality Control Department, U. S. Public Health Service Supply Service Center, Perry Point, Maryland 21902
N1 - Accession Number: 11-1532; Language: English; Chemical Name: Theophylline--5967-84-0; Therapeutic Class: (12:08.08); AHFS Class: Spasmolytics theophylline; References: 2; Publication Type: Quality Control and Drug Analysis; Journal Coden: AJHPA9; Section Heading: Drug Analysis; Abstract Author: Joan Lentine
N2 - Theophylline elixir, 80 mg./15 ml., was analyzed by UV spectrometry following a column chromatographic separation. The technique used was based on the NF XIII procedure for Theophylline, Ephedrine HCl and Phenobarbital Tablets.
KW - Theophylline--elixirs-;
KW - Elixirs--theophylline--spectrometry, ultraviolet, following chromatographic separation;
KW - Spectrometry, ultraviolet--theophylline--elixirs, following chromatographic separation;
KW - Chromatography, column--theophylline--elixirs, and UV spectrometry;
KW - Spasmolytics--theophylline--elixirs, UV spectrometry following chromatographic separation;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-1532&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Farshy, D. C.;
T1 - Tributoxyethyl phosphate as a contaminant in B-D vacutainers
CT - Tributoxyethyl phosphate as a contaminant in B-D vacutainers
JO - Appl. Microbiol.
JF - Appl. Microbiol.
Y1 - 1974/02/01/
VL - 27
IS - Feb
SP - 300
EP - 302
AD - Center for Disease Control, Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 12-4172; Language: English; References: 5; Journal Coden: APMBAY; Human Indicator: Yes; Section Heading: Environmental Toxicity; Pharmaceutical Technology; Abstract Author: Irving S. Rossoff
N2 - Tributoxyethyl phosphate (I), a compound not found in blood serum of healthy human controls, was found to be a contaminant in the B-D Vacutainers used to collect blood from a group of patients. The I has triglyceride characteristics on TLC plates, and could also give erroneous serum phosphorus readings.
KW - Tributoxyethyl phosphate--contamination-;
KW - Contamination--tributoxyethyl phosphate--in B-D Vacutainers, in patients;
KW - Containers--contamination--tributoxyethyl phosphate, in B-D Vacutainers, in patients;
KW - Toxicity, environmental--tributoxyethyl phosphate--contamination, in B-D Vacutainers, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4172&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wilson, C. H.;
T1 - Fluorometric determination of formaldehyde in cosmetic products
CT - Fluorometric determination of formaldehyde in cosmetic products
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1974/02/01/
VL - 25
IS - Feb
SP - 67
EP - 71
SN - 00379832
AD - Division of Cosmetics Technology, Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Washington, D. C. 20204
N1 - Accession Number: 11-3596; Language: English; Chemical Name: Formaldehyde--50-00-0; Therapeutic Class: (38:00); AHFS Class: Disinfectants formaldehyde (84:24); AHFS Class: Lotions formaldehyde (84:24); AHFS Class: Creams formaldehyde; References: 2; Journal Coden: JSCCA5; Section Heading: Drug Analysis
N2 - To overcome interference by perfume ingredients, a method was developed for determining formaldehyde in cosmetics by forming a fluorescent lutidine derivative and measuring the fluorescence on a spectrophotofluorometer. Satisfactory recoveries were obtained from samples of shampoos, bath oils, hair cosmetics, lotions, and creams to which formaldehyde had been added. Formaldehyde was also determined in commercial samples of nail hardener, bubble bath, hair rinse, and shampoos. Of 7 other aldehydes examined, only an aryl sulfonamide-formaldehyde resin gave a false positive test.
KW - Formaldehyde--cosmetics-;
KW - Fluorometry--formaldehyde--cosmetics;
KW - Preservatives--formaldehyde--cosmetics, fluorometry;
KW - Disinfectants--formaldehyde--cosmetics, fluorometry;
KW - Shampoos--formaldehyde--fluorometry;
KW - Oils--bath--formaldehyde, fluorometry;
KW - Lotions--formaldehyde--fluorometry;
KW - Creams--formaldehyde--fluorometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3596&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Weissler, A.;
T1 - Scientific basis for FDA regulatory activities in cosmetics
CT - Scientific basis for FDA regulatory activities in cosmetics
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1974/02/01/
VL - 25
IS - Feb
SP - 99
EP - 07
SN - 00379832
AD - Division of Color Technology, Food and Drug Administration, HEW, Washington, D.C. 20204
N1 - Accession Number: 11-3847; Language: English; References: 4; Journal Coden: JSCCA5; Section Heading: Legislation, Laws and Regulations
N2 - Increased safety for users of cosmetics is the goal of Food and Drug Administration activities in cosmetics. In order for these activities to be effective, they must have a sound scientific basis. The scientific projects and capabilities at FDA in the field of cosmetics are surveyed in terms of their impingement on regulatory matters. It deserves note that the scientific basis for regulatory actions may involve not only facts, but also judgments as well; the reason is that in some cases the available factual information is not complete or definitive. A brief discussion is given of recent examples, such as bubble baths, asbestos in talcum powders, and mercury preservatives in cosmetics.
KW - Food and Drug Administration (U.S.)--cosmetics--safety, responsibilities;
KW - Cosmetics--safety--responsibilities, FDA;
KW - Regulations--cosmetics--safety, FDA responsibilities;
KW - Safety--cosmetics--regulations, FDA responsibilities;
KW - Toxicity--cosmetics--regulations, FDA responsibilities;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3847&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1975-12310-001
AN - 1975-12310-001
AU - Rogers, Malcolm P.
AU - Kelly, Martin J.
T1 - General hospital consultation.
JF - Psychiatric Opinion
JO - Psychiatric Opinion
Y1 - 1974/02//
VL - 11
IS - 1
SP - 36
EP - 42
CY - US
PB - Opinion Publications
N1 - Accession Number: 1975-12310-001. Partial author list: First Author & Affiliation: Rogers, Malcolm P.; US Public Health Service Indian Hosp, Rosebud, SD. Release Date: 19750601. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Case Report; Organ Transplantation; Professional Consultation; Surgical Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Methodology: Clinical Case Study. Page Count: 7. Issue Publication Date: Feb, 1974.
AB - Describes a psychiatric consultation with a 36-yr-old male patient who had undergone kidney transplant. The significance of the time and circumstances of the consultation is pointed out. The patient's problems and difficulties in deciding to have the operation, especially in discussing it with his wife and doctors, are detailed. The fundamental psychic meaning of hospitalization for the patient is presented. The great need for empathy with the patient in psychiatric consultations is emphasized. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - general hospital psychiatric consultation
KW - 36-yr-old kidney transplant patient
KW - 1974
KW - Case Report
KW - Organ Transplantation
KW - Professional Consultation
KW - Surgical Patients
KW - 1974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1975-12310-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Ingestion trends of children under 5 years of age
CT - Ingestion trends of children under 5 years of age
JO - Bull. Natl. Clearinghouse Poison Contr. Cent.
JF - Bull. Natl. Clearinghouse Poison Contr. Cent.
Y1 - 1974/03/01/
VL - Pages
IS - Mar-Apr
SP - 1
EP - 6
AD - Food and Drug Administration, Bureau of Drugs, 5401 Westbard Avenue, Bethesda, Maryland 20016
N1 - Accession Number: 11-3698; Language: English; Journal Coden: NCPBBY; Human Indicator: Yes; Section Heading: Toxicity; Sociology, Economics and Ethics; Abstract Author: Douglas L. Thompson
N2 - Statistical data related to the poisoning of children under 5 years of age for the period 1959 through 1972 are presented in table and chart forms.
KW - Poisoning--pediatrics--statistics, 1959-1972;
KW - Statistics--poisoning--pediatrics, 1959-1972;
KW - Toxicity--poisoning--statistics, 1959-1972, pediatrics;
KW - Pediatrics--poisoning--statistics, 1959-1972;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3698&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Levine, J.;
T1 - Evolution of pharmaceutical analysis
CT - Evolution of pharmaceutical analysis
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/03/01/
VL - 57
IS - Mar
SP - 237
EP - 242
AD - Division of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-3627; Language: English; Publication Type: Wiley Award Address; Journal Coden: JANCA2; Section Heading: History; Abstract Author: Douglas L. Thompson
N2 - A brief historical review of the development of the field of pharmaceutical analysis from 1906 to 1973 is presented. Changes in USP and NF methods are emphasized.
KW - Analysis--pharmaceutical--history;
KW - History--analysis--pharmaceutical;
KW - Compendia--analysis--history, developments;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3627&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Collaborative study of the determination of sulfaquinoxaline, sulfathiazole, sulfamerazine, and sulfamethazine in feed concentrates and premixes
CT - Collaborative study of the determination of sulfaquinoxaline, sulfathiazole, sulfamerazine, and sulfamethazine in feed concentrates and premixes
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/03/01/
VL - 57
IS - Mar
SP - 345
EP - 348
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 11-3380; Language: English; Chemical Name: Sulfaquinoxaline--59-40-5 Sulfathiazole--72-14-0 Sulfamerazine--127-79-7 Sulfamethazine--57-68-1; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A spectrophotometric method for determining sulfaquinoxaline and total sulfonamides and a TLC method for determining sulfathiazole, sulfamerazine, and sulfamethazine in feed concentrates and premixes were subjected to collaborative study.
KW - Sulfaquinoxaline--combination, sulfamerazine, sulfamethazine, sulfathiazole-;
KW - Sulfathiazole--combination, sulfamerazine, sulfamethazine, sulfaquinoxaline-;
KW - Sulfamerazine--combination, sulfamethazine, sulfaquinoxaline, sulfathiazole-;
KW - Sulfamethazine--combination, sulfamerazine, sulfaquinoxaline, sulfathiazole-;
KW - Feeds--sulfonamides--spectrometry, ultraviolet and TLC;
KW - Sulfonamides--feeds--and premixes, UV spectrometry and TLC;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3380&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bailey, J. E.;
AU - Graichen, C.;
T1 - Automatic potentiometric titration of sodium sulfate in certifiable water soluble colors
CT - Automatic potentiometric titration of sodium sulfate in certifiable water soluble colors
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/03/01/
VL - 57
IS - Mar
SP - 353
EP - 355
AD - Division of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-3593; Language: English; Chemical Name: Sodium sulfate--7727-73-3; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Sodium sulfate--potentiometry-;
KW - Dyes--sodium sulfate--constituents, potentiometry;
KW - Potentiometry--sodium sulfate--in certifiable water soluble dyes;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3593&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graichen, C.;
AU - Bailey, J. E.;
T1 - Automatic potentiometric titration of sodium chloride in certifiable water soluble colors
CT - Automatic potentiometric titration of sodium chloride in certifiable water soluble colors
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/03/01/
VL - 57
IS - Mar
SP - 356
EP - 357
AD - Division of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-3379; Language: English; Chemical Name: Sodium chloride--7647-14-5; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Sodium chloride--potentiometry-;
KW - Potentiometry--sodium chloride--in water soluble dyes;
KW - Dyes--potentiometry--constituents, sodium chloride;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3379&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
T1 - Determination of uncombined intermediates in FD&C Yellow No. 6 by high pressure liquid chromatography
CT - Determination of uncombined intermediates in FD&C Yellow No. 6 by high pressure liquid chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/03/01/
VL - 57
IS - Mar
SP - 358
EP - 359
AD - Division of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-3381; Language: English; Chemical Name: FD&C Yellow No. 6--2783-94-0; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - FD&C Yellow No. 6--chromatography, liquid-;
KW - Chromatography, liquid--FD&C Yellow No. 6--high pressure, detection, uncombined intermediates;
KW - Dyes--FD&C Yellow No. 6--chromatography, liquid, high pressure, detection, uncombined intermediates;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3381&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Medwick, T.;
T1 - NMR Analysis of pharmaceuticals. 12. Determination of amantadine hydrochloride in soft gelatin capsules and syrups
CT - NMR Analysis of pharmaceuticals. 12. Determination of amantadine hydrochloride in soft gelatin capsules and syrups
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/03/01/
VL - 63
IS - Mar
SP - 425
EP - 427
SN - 00223549
AD - Food and Drug Administration, HEW, Brooklyn, New York 11232
N1 - Accession Number: 12-2820; Language: English; Chemical Name: Amantadine--768-94-5; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents amantadine; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Amantadine--syrups-;
KW - Antiparkinson agents--amantadine--syrups, and soft gelatin capsules, NMR spectrometry;
KW - Spectrometry, nuclear magnetic resonance--amantadine--syrups, and soft gelatin capsules;
KW - Capsules--amantadine--gelatin, soft, and syrups, NMR spectrometry;
KW - Syrups--amantadine--and soft gelatin capsules, NMR spectrometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2820&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Margosis, M.;
T1 - GLC Analysis of chloramphenicol: a collaborative study
CT - GLC Analysis of chloramphenicol: a collaborative study
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/03/01/
VL - 63
IS - Mar
SP - 435
EP - 437
SN - 00223549
AD - National Center for Antibiotic Analysis, Food and Drug Administration, HEW, Washington, D.C. 20204
N1 - Accession Number: 12-3270; Language: English; Chemical Name: Chloramphenicol--56-75-7; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Chloramphenicol--chromatography, gas-;
KW - Chromatography, gas--chloramphenicol--collaborative studies;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3270&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kohen, D. P.;
T1 - Neonatal gonococcal arthritis: three cases and review of the literature
CT - Neonatal gonococcal arthritis: three cases and review of the literature
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1974/03/01/
VL - 53
IS - Mar
SP - 436
EP - 440
SN - 00314005
AD - Dept. of Pediatrics, U.S. Public Health Service Indian Hospital, Fort Defiance, Arizona 86504
N1 - Accession Number: 12-4656; Language: English; Chemical Name: Penicillin--1406-05-9 Kanamycin--59-01-8 Silver nitrate--7761-88-8; References: 31; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Brenda Sue Martinez
N2 - Four case reports of neonatal disseminated gonococcal infection including a table of the clinical and laboratory features and therapy of 10 reported cases are presented. Of the 4 cases, 3 developed gonococcal arthritis, which was treated with aqueous crystalline penicillin G 100,000 u/kg/day IV in 2 divided doses for at least a week, then IM for another week. The fourth patient received kanamycin for 5 days and 1 week of IM penicillin therapy. Although the infants received silver nitrate 1% prophylaxis at birth, 2 subsequently developed gonococcal ophthalmia. Preventive prenatal measures are recommended.
KW - Penicillin--alone and with kanamycin-;
KW - Kanamycin--and penicillin-;
KW - Silver nitrate--arthritis-;
KW - Arthritis--gonococcal--penicillin, therapy, in infants;
KW - Combined therapy--penicillin and kanamycin--infections, gonococcal, therapy, in infants;
KW - Combined therapy--kanamycin and penicillin--infections, gonococcal, therapy, in infants;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4656&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Weissler, A.;
T1 - Fluorometric analysis
CT - Fluorometric analysis
JO - Anal. Chem.
JF - Anal. Chem.
Y1 - 1974/04/01/
VL - 46
IS - Apr
SP - 500R
EP - 521R
AD - Division of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 11-3793; Language: English; References: 1028; Publication Type: Review; Journal Coden: ANCHAM; Section Heading: Pharmaceutical Chemistry; Drug Analysis; Abstract Author: Douglas L. Thompson
N2 - The literature on fluorometric analysis is reviewed for the period December 1971 to December 1973. Papers on atomic fluorescence and x-ray fluorescence are omitted. The literature relating to vitamins, amines, amino acids, proteins, enzymes, nucleotides, nucleic acids, steroids, hormones, pharmaceuticals and immunofluorescence are included.
KW - Fluorometry--review--including drugs;
KW - Drugs--fluorometry--review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3793&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Karchmer, R. K.;
AU - Amare, M.;
AU - Larsen, W. E.;
AU - Mallouk, A. G.;
AU - Caldwell, G. G.;
T1 - Alkylating agents as leukemogens in multiple myeloma
CT - Alkylating agents as leukemogens in multiple myeloma
JO - Cancer (Philadelphia)
JF - Cancer (Philadelphia)
Y1 - 1974/04/01/
VL - 33
IS - Apr
SP - 1103
EP - 1107
AD - Ecological Investigations Program, Center of Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Dept. of Health, Education, and Welfare, Kansas City, Kansas) (Reprints: Cancer and Birth Defects Branch, Bureau of Epidemiology, Center of Disease Control, Atlanta, Georgia 30333
N1 - Accession Number: 12-3976; Language: English; References: 40; Journal Coden: CANCAR; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The development of acute leukemia among 5 patients with a prior history of multiple myeloma is discussed. Application of age/sex-specific leukemia rates to an estimated population with multiple myeloma living in the area during a 7-year collection period indicates that 0.17 patients would be expected to develop acute leukemia. The 5 patients in the study represent a significant increase in the observed over the expected incidence. Twenty-six patients have now been reported to develop acute leukemia during treatment of multiple myeloma; each had received an alkylating agent. These drugs may be direct leukemogens and the risk involved in their use must be recognized.
KW - Antineoplastic agents--myelomas--therapy, and increased incidence of acute leukemia, in patients;
KW - Toxicity--antineoplastic agents--leukemias, increased incidence after myeloma therapy, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3976&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Roos, R. W.;
T1 - Identification and determination of synthetic estrogens in pharmaceuticals by high speed, reversed phase partition chromatography
CT - Identification and determination of synthetic estrogens in pharmaceuticals by high speed, reversed phase partition chromatography
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/04/01/
VL - 63
IS - Apr
SP - 594
EP - 599
SN - 00223549
AD - Food and Drug Administration, HEW, Brooklyn, New York 11232
N1 - Accession Number: 12-3485; Language: English; References: 25; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Application of a high speed liquid chromatographic method to the analysis of synthetic estrogens in commercial preparations is described.
KW - Estrogens--synthetic--chromatography, liquid, high speed, in dosage forms;
KW - Chromatography, liquid--estrogens--synthetic, in dosage forms;
KW - Dosage forms--estrogens--synthetic, high speed liquid chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3485&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1974-27738-001
AN - 1974-27738-001
AU - Hammerschlag, Carl A.
T1 - Using T-groups to train American Indians as physician assistants.
JF - Hospital & Community Psychiatry
JO - Hospital & Community Psychiatry
JA - Hosp Community Psychiatry
Y1 - 1974/04//
VL - 25
IS - 4
SP - 210
EP - 213
CY - US
PB - American Psychiatric Assn
SN - 0022-1597
N1 - Accession Number: 1974-27738-001. Other Journal Title: Psychiatric Services. Partial author list: First Author & Affiliation: Hammerschlag, Carl A.; Indian Health Service, Phoenix, Ariz. Release Date: 19741001. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Community Mental Health Training; Group Dynamics; Paraprofessional Personnel; Sensitivity Training. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 4. Issue Publication Date: Apr, 1974.
AB - Describes the use of T-groups as a learning experience in group dynamics for 10 American Indians who were being trained as physician assistants. The groups emphasized adapting to the anxiety created by new career goals, understanding the question of identity as it relates to Indians, and reducing the hostility created by different expectations the Indian has for himself and his community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - T-groups as learning experience in group dynamics
KW - training as physician assistants
KW - American Indians
KW - 1974
KW - American Indians
KW - Community Mental Health Training
KW - Group Dynamics
KW - Paraprofessional Personnel
KW - Sensitivity Training
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42006-029
AN - 2013-42006-029
AU - Archibald, Charles W. Jr.
T1 - Review of Family networks.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1974/04//
VL - 44
IS - 3
SP - 468
EP - 469
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42006-029. Partial author list: First Author & Affiliation: Archibald, Charles W. Jr.; Indian Health Service, U.S. Public Health Service, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Family Members; Social Mobility; Social Networks. Minor Descriptor: Collaboration. Classification: Social Processes & Social Issues (2900). Population: Human (10). Reviewed Item: Speck, Ross V.; Attneave, Carolyn L. Family networks=163 pp. $6.95. Pantheon, New York; 1973. Page Count: 2. Issue Publication Date: Apr, 1974.
AB - Reviews the book, Family Networks by Ross V. Speck and Carolyn L. Attneave (see record [rid]1974-01685-000[/rid]). Building on R. D. Laing's theories about the social and familial forces that determine our lives, Dr. Attneave has joined Dr. Speck in developing a well-constructed and adequately field-tested method of catalyzing the concern of the social network that surrounds the identified patient through a six-step process that has proven effective by a well-trained team of intervenors: Retribalization, Polarization, Mobilization, Depression, Breakthrough, and Exhaustion and Elation. The authors point out other uses of the method in teaching social network theory intervention, in professional association problems, and understanding institutional network functioning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family networks
KW - social networks
KW - mobilization
KW - professional association
KW - 1974
KW - Family Members
KW - Social Mobility
KW - Social Networks
KW - Collaboration
KW - 1974
U2 - Speck, Ross V.; Attneave, Carolyn L. (1973); Family networks; 163 pp. $6.95. Pantheon, New York
DO - 10.1037/h0097729
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42006-029&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Josephson, M. E.;
AU - Caracta, A. R.;
AU - Ricciutti, M. A.;
AU - Lau, S. H.;
AU - Damato, A. N.;
T1 - Electrophysiologic properties of procainamide in man
CT - Electrophysiologic properties of procainamide in man
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
Y1 - 1974/05/01/
VL - 33
IS - May
SP - 596
EP - 603
AD - Cardiopulmonary Laboratory, U.S. Public Health Service Hospital, Staten Island, New York 10304
N1 - Accession Number: 12-5044; Language: English; Chemical Name: Procainamide--51-06-9; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs procainamide; References: 38; Journal Coden: AJCDAG; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The electrophysiologic properties of procainamide (I) were studied in 16 patients and were correlated with plasma levels. I caused a minimal prolongation of atrioventricular (A-V) nodal conduction in 11 patients during sinus rhythm, but His-Purkinje conduction time was significantly prolonged in 15 patients. The effective refractory period of the atrium was prolonged by I in 14 patients. The effective refractory period of the A-V node decreased in 8 of 9 patients. This may have been due to (1) anticholinergic properties of I; (2) production of an A-V nodal gap by I; or (3) an apparent A-V nodal block that actually represented decremental conduction in the His bundle; I then caused delay in the A-V node allowing improved intra-His conduction and ventricular depolarization. The relative refractory period of the His-Purkinje system was prolonged in 10 of 11 patients. The effective refractory period was prolonged in 1 patient, unchanged in a second and apparently shortened in a third. In this third patient, I produced a marked delay in proximal His-Purkinje conduction allowing a distal area of refractoriness to recover, thus causing apparent shortening of the effective refractory period. Plasma levels averaged 7.1 mg/l at the end of the study; no toxicity was noted.
KW - Procainamide--blood levels-;
KW - Blood levels--procainamide--and effects, cardiac conduction, in patients;
KW - Cardiac drugs--procainamide--blood levels, and effects, cardiac conduction, in patients;
KW - Metabolism--procainamide--blood levels, and effects, cardiac conduction, in patients;
KW - Mechanism of action--procainamide--conduction, cardiac, in patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5044&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Levels of sterility: probabilities of survivors vs. biological indicators
CT - Levels of sterility: probabilities of survivors vs. biological indicators
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1974/05/01/
VL - 28
IS - May-Jun
SP - 105
EP - 121
AD - Office of Medical Devices, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-1413; Language: English; References: 21; Journal Coden: BUYRAI; Section Heading: Pharmaceutical Technology
N2 - A review of sterility assurance procedures for large volume parental solutions is presented. Increased numbers of samples for finished product sterility tests can never assure a survivor probability of [10\-/\SU/6\BS/.]The simplest way that this survivor probability can be measured is through the use of deliberate biological challenges (biological indicators), whose sterilization resistance has been defined in relation to the natural contaminants of the product. Alternately, with moist heat cycles an integrated lethality curve can be determined by plotting lethal rates vs. temperatures recorded in center of load by thermocouple measurements.
KW - Sterility--tests--injections, I.V., methods, review;
KW - Tests--sterility--injections, I.V., methods, review;
KW - Injections--intravenous--sterility, tests, methods, review;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1413&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mitchell, C. M.;
T1 - Anticipated revisions to the current good manufacturing practice regulations
CT - Anticipated revisions to the current good manufacturing practice regulations
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1974/05/01/
VL - 28
IS - May-Jun
SP - 146
EP - 151
AD - Office of Compliance, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-1690; Language: English; Chemical Name: Penicillin--1406-05-9; Journal Coden: BUYRAI; Section Heading: Legislation, Laws and Regulations; Abstract Author: Robert M. Cooper
N2 - A discussion of proposed revisions in the Current Good Manufacturing Practice Regulations of the Food and Drug Administration is presented. The revisions may be classified as follows: (1) the requirement of expiration dates on all drug products; (2) the lowering of penicillin contamination levels in nonpenicillin products; (3) the requirement of written procedures for most manufacturing and control operations; and (4) miscellaneous (establishment of a section on sanitation, retention of drug component samples and information required on laboratory results of analyses).
KW - Penicillin--contamination-;
KW - Good Manufacturing Practices--regulations--revisions, proposed, discussion;
KW - Regulations--Good Manufacturing Practices--revisions, proposed, discussion;
KW - Food and Drug Administration (U.S.)--Good Manufacturing Practices--regulations, proposed revisions, discussion;
KW - Expiration dates--labeling--requirements, proposed revisions of GMP, discussion;
KW - Drugs--expiration dates--labeling, requirements, proposed revisions of GMP, discussion;
KW - Labeling--expiration dates--revisions, proposed, in Good Manufacturing Practice regulations, discussion;
KW - Contamination--penicillin--Good Manufacturing Practices, revisions, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1690&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Marzulli, F. N.;
AU - Maibach, H. I.;
T1 - Brominated salicylanilides\M/structure-activity relationships
CT - Brominated salicylanilides\M/structure-activity relationships
JO - Cosmet. Perfum.
JF - Cosmet. Perfum.
Y1 - 1974/05/01/
VL - 89
IS - May
SP - 51
EP - 53
AD - Dermal Toxicity Branch, Division of Toxicology, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 11-4394; Language: English; Language of Summary: fr; ger; sp; Chemical Name: Salicylanilide--87-17-2; Therapeutic Class: (38:00); AHFS Class: Disinfectants salicylanilide; References: 10; Journal Coden: CSPEAX; Section Heading: Toxicity; Pharmaceutical ChemistryPharmacology; Abstract Author: Douglas L. Thompson
N2 - The photoallergenic potential of brominated salicylanilides may be inversely related to their degree of bromination. Data related to photoallergenic reactions to mono-, di-, tri-, and tetrabromosalicylanilide are discussed.
KW - Salicylanilide--brominated-;
KW - Monobromosalicylanilide--photosensitivity-;
KW - Dibromosalicylanilide--photosensitivity-;
KW - Tribromosalicylanilide--photosensitivity-;
KW - Tetrabromosalicylanilide--photosensitivity-;
KW - Structure-activity relationships--salicylanilide--brominated, and photosensitivity;
KW - Toxicity--salicylanilide--brominated, photosensitivity and structure-activity relationships;
KW - Disinfectants--salicylanilide--brominated, photosensitivity, structure-activity relationships;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-4394&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Crout, J. R.;
T1 - Fixed combination prescription drugs: FDA policy
CT - Fixed combination prescription drugs: FDA policy
JO - Hosp. Formul. Manage.
JF - Hosp. Formul. Manage.
Y1 - 1974/05/01/
VL - 9
IS - May
SP - 30
EP - 38
AD - Bureau of Drugs, Food and Drug Administration, Rockville, Maryland
N1 - Accession Number: 11-3850; Language: English; Journal Coden: HOFMAY; Section Heading: History; Abstract Author: Arnett J. Holloway
N2 - The Food and Drug Administration's legal stand on combination drugs is examined, especially the requirement that substantial evidence based on clinical trials show the effectiveness of each ingredient involved and the effect of a dosage on a significant patient population.
KW - Food and Drug Administration (U.S.)--combinations--fixed, FDA policy;
KW - Prescriptions--combinations--fixed, FDA policy;
KW - Regulations--combinations--fixed, FDA policy;
KW - Drugs, clinical effectiveness--combinations--fixed, FDA policy;
KW - Dosage--combinations--fixed, FDA policy on effectiveness of each ingredient;
KW - Drugs--combinations--fixed, FDA policy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3850&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Crout, J. R.;
T1 - Fixed combination prescription drugs: FDA policy
CT - Fixed combination prescription drugs: FDA policy
JO - Journal of Clinical Pharmacology (USA)
JF - Journal of Clinical Pharmacology (USA)
Y1 - 1974/05/01/
VL - 14
IS - May-Jun
SP - 249
EP - 254
SN - 00912700
AD - Bureau of Drugs, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-4176; Language: English; Journal Coden: JCPCBR; Section Heading: Legislation, Laws and Regulations; Abstract Author: James B. Lumbard
N2 - The history and justification for the FDA policy on fixed combination prescription drugs is presented.
KW - Administration--policies and procedures--Food and Drug Administration, on fixed combination prescription drugs;
KW - Food and Drug Administration (U.S.)--prescriptions--combinations, policies and procedures;
KW - Prescriptions--combinations--policies and procedures, FDA;
KW - Regulations--Food and Drug Administration--policies and procedures, on fixed combination prescription drugs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4176&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, J. H.;
AU - Banes, D.;
AU - Biesemeyer, M. E.;
AU - Nadkarni, A.;
T1 - Analysis of sodium levothyroxine or sodium liothyronine in tablets
CT - Analysis of sodium levothyroxine or sodium liothyronine in tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/05/01/
VL - 63
IS - May
SP - 763
EP - 766
SN - 00223549
AD - Div. of Drug Chemistry, Food and Drug Administration, HEW, Washington, D.C. 20204
N1 - Accession Number: 12-2518; Language: English; Chemical Name: Levothyroxine--51-48-9 Liothyronine--6893-02-3; References: 5; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - The active ingredients from levothyroxine and liothyronine tablets, were isolated by partition chromatography and analyzed spectrophotometrically following reduction to triiodide ion. This method is extremely sensitive, and may be applied conveniently to dosage levels as low as 5 mcg.
KW - Levothyroxine--tablets-;
KW - Liothyronine--tablets-;
KW - Tablets--liothyronine--chromatography, column and UV spectrometry;
KW - Tablets--levothyroxine--chromatography, column, and UV spectrometry;
KW - Chromatography, column--liothyronine--tablets, and triiodide UV spectrometry;
KW - Chromatography, column--levothyroxine--tablets, and triiodide UV spectrometry;
KW - Spectrometry, ultraviolet--levothyroxine--tablets, and column chromatography;
KW - Spectrometry, ultraviolet--liothyronine--tablets, and column chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-2518&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - WHITNEY JR., ROBERT A.
T1 - Ectromelia in U.S. Mouse Colonies.
JO - Science
JF - Science
Y1 - 1974/05/10/
VL - 184
IS - 4137
M3 - Article
SP - 609
EP - 609
SN - 00368075
N1 - Accession Number: 85345514; WHITNEY JR., ROBERT A. 1; Affiliations: 1: Veterinary Resources Branch, Division of Research Services, Public Health Service, National Institutes of Health, Bethesda, Maryland 20014; Issue Info: 5/10/1974, Vol. 184 Issue 4137, p609; Number of Pages: 2/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Brennan, E. C.;
AU - Hamet, S. H.;
AU - Gasdia, S. D.;
T1 - Comparative evaluation of the moisture-tightness of various prescription containers
CT - Comparative evaluation of the moisture-tightness of various prescription containers
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1974/06/01/
VL - 31
IS - Jun
SP - 600
EP - 601
SN - 00029289
AD - U.S. Public Health Service Supply Service Center, Perry Point, Maryland 21902
N1 - Accession Number: 11-3173; Language: English; Chemical Name: Polystyrene--9003-53-6; Publication Type: Quality Control and Drug Analysis; Journal Coden: AJHPA9; Section Heading: Pharmaceutical Technology
N2 - A test was developed to evaluate the comparative moisture resistance of various prescription containers. The test consists of placing 2 g. of anhydrous calcium chloride into each container, closing the container and weighing it. The containers are then placed in a constant humidity chamber (86% relative humidity) at room temperature and weighed at one-week intervals over a period of 4 weeks. The percentage increase in weight is taken as a comparative measure of the container's moisture resistance. Thirteen different prescription containers were tested. Glass vials with lined, phenolic screw cap closures provided the best protection against penetration by moisture vapor; an amber polystyrene vial with a child resistant closure was the least effective among the containers tested.
KW - Polystyrene--containers-;
KW - Containers--prescriptions--tests, moisture penetration;
KW - Prescriptions--containers--tests, moisture, penetration;
KW - Tests--containers--prescriptions, moisture penetration;
KW - Moisture--tests--containers, prescriptions, penetration;
KW - Glass--containers--prescriptions, tests for moisture penetration;
KW - Plastics--containers--prescriptions, tests for moisture penetration;
KW - Closures--safety--tests, moisture penetration, prescription containers;
KW - Closures--containers--prescriptions, moisture penetration;
KW - Packaging--prescriptions--containers, test for moisture penetration;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=11-3173&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Walters, P. G.;
T1 - FDA's program to improve consumers' and health professionals' ability to select medically effective drugs
CT - FDA's program to improve consumers' and health professionals' ability to select medically effective drugs
JO - Hosp. Formul. Manage.
JF - Hosp. Formul. Manage.
Y1 - 1974/06/01/
VL - 9
IS - Jun
SP - 17
EP - 50
AD - Office of Scientific Evaluation, Bureau of Drugs, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-3325; Language: English; Journal Coden: HOFMAY; Section Heading: Methodology; Abstract Author: Pamela N. Davis
N2 - The basic safety and efficacy standard of the FDA is reviewed, and several areas of endeavor are described, namely fixed combination drugs products, over-the-counter drugs, drug advertising, and generic prescribing. It is stated that the requirement for adequate and well controlled trials is essential.
KW - Drugs, over-the-counter--Food and Drug Administration--standards, efficacy and safety;
KW - Advertising--Food and Drug Administration--standards, efficacy and safety;
KW - Prescriptions--generic--efficacy, and safety FDA standards;
KW - Food and Drug Administration (U.S.)--drugs--standards, efficacy and safety;
KW - Safety--drugs--standards, FDA;
KW - Methodology--clinical studies--need, for well controlled trials;
KW - Equivalency, generic--efficacy--and safety, FDA standards;
KW - Toxicity--drugs--standards, FDA;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3325&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Allen, L.;
T1 - Quantitative determination of carisoprodol, phenacetin, and caffeine in tablets by near-IR spectrometry and their identification by TLC
CT - Quantitative determination of carisoprodol, phenacetin, and caffeine in tablets by near-IR spectrometry and their identification by TLC
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/06/01/
VL - 63
IS - Jun
SP - 912
EP - 916
SN - 00223549
AD - Food and Drug Administration, HEW, Brooklyn, New York 11232
N1 - Accession Number: 12-1952; Language: English; Chemical Name: Carisoprodol--78-44-4 Phenacetin--62-44-2 Caffeine--58-08-2; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Carisoprodol--combination, caffeine, phenacetin-;
KW - Phenacetin--combination, caffeine, carisoprodol-;
KW - Caffeine--combination, carisoprodol, phenacetin-;
KW - Spectrometry, infrared--carisoprodol, combination, caffeine, phenacetin--and chromatography, thin layer, identification and quantitation;
KW - Chromatography, thin layer--carisoprodol, combination, caffeine, phenacetin--and spectrometry, infrared, identification and quantitation;
KW - Tablets--carisoprodol, combination, caffeine, phenacetin--spectrometry, infrared, and TLC quantitation and identification;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1952&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Starmer, C. Frank
AU - Grizzle, James E.
AU - Sen, P. K.
T1 - Comment, by C. Frank Starmer, James E. Grizzle and P. K. Sen.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/06//
VL - 69
IS - 346
M3 - Article
SP - 376
SN - 01621459
AB - In the discussion of hypothesis testing in 2 X 2 contingency tables, Fisher's exact test is often used as the standard against which competing tests are measured. Statisticians should not be led into a semantic trap by the words "exact test." Statistician interpreted the phrase to mean that it yields the exact probability of observing a result identical to a more extreme probability under the assumption that a particular 2 X 2 table was generated by sampling from a four-variable hypergeometric distribution. The result shown by statistician K.D. Tocher shows that the exact test, supplemented by randomization to achieve the desired significance α is the most powerful test against one-sided alternatives when both, one or no margin totals are fixed in advance. Therefore, the randomized exact test should be the standard to which competing tests are compared. Even though most statisticians would not use the randomized test in practice, it could be used for judging the value of competing tests.
KW - STATISTICAL hypothesis testing
KW - PROBABILITY theory
KW - DISTRIBUTION (Probability theory)
KW - SAMPLING (Statistics)
KW - CONTINGENCY tables
KW - CONTINUITY
KW - FISHER exact test
KW - HYPERGEOMETRIC distribution
KW - HYPOTHESIS
N1 - Accession Number: 4608361; Starmer, C. Frank 1,2; Grizzle, James E. 3; Sen, P. K. 3; Affiliations: 1: Associate professor of computer science and assistant professor of medicine, Department of Medicine, Duke University, Durham, N.C. 27710.; 2: Recipient of Research Career Development Award 1-K4-HL-70, 102, U.S. Public Health Service.; 3: Professor, Department of Biostatistics, University of North Carolina, Chapel Hill, N.C. 27514.; Issue Info: Jun74, Vol. 69 Issue 346, p376; Thesaurus Term: STATISTICAL hypothesis testing; Thesaurus Term: PROBABILITY theory; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: SAMPLING (Statistics); Subject Term: CONTINGENCY tables; Subject Term: CONTINUITY; Subject Term: FISHER exact test; Subject Term: HYPERGEOMETRIC distribution; Subject Term: HYPOTHESIS; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
TY - GEN
AU - Schmidt, A. M.;
T1 - Interrelationship between pharmacy and FDA
CT - Interrelationship between pharmacy and FDA
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1974/06/01/
VL - 40
IS - Jun
SP - 38
EP - 42
SN - 00030627
AD - Food and Drug Administration, 5600 Fishers Lane Rockville, Maryland
N1 - Accession Number: 12-3536; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacy Practice; Abstract Author: Walter F. Stanaszek
N2 - The interrelation of the FDA and pharmacists and how this relationship may affect the future roles of both are explored. The current FDA review of over-the-counter drugs is discussed in terms of its structure, impact on the practicing pharmacist, and goals. These goals include: (1) review the safety of all over-the-counter drugs; (2) evaluate their effectiveness; (3) improve labeling; and (4) provide a better system for regulating such drugs in the future. Pharmacy is urged to participate in the forthcoming major public education program on over-the-counter drugs, their limitations, and their possible misuse. Other issues discussed are the development of uniform guidelines for prescription drug labeling, the proposed national drug compendium, and patient package inserts.
KW - Food and Drug Administration (U.S.)--pharmacy--relationships, and use of over-the-counter drugs;
KW - Pharmacy--Food and Drug Administration--relationships, and use of over-the-counter drugs;
KW - Drugs, over-the-counter--use--and roles, FDA and pharmacy, discussion;
KW - Education--drugs, over-the-counter--role, pharmacists;
KW - Labeling--drugs--improved, goal of FDA;
KW - Package inserts--drugs--guidelines, role of FDA;
KW - Compendia--drugs--national, and FDA, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3536&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Williams, Stephen J.
AU - McIntosh, E. Noel
T1 - Requirements for Abortion Services.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/07//
VL - 64
IS - 7
M3 - Article
SP - 716
EP - 717
PB - American Public Health Association
SN - 00900036
AB - The article analyzes the demands of abortion services in the U.S. and discusses the required services of abortion in the health care delivery system. It analyzes the data obtained in 1971 from various women who undergone abortion services. The number of abortion was estimated through the use of abortion and morbility rates. The meaning of morbility which was used in the study were oriented toward patients that needs further care and medication. Medical follow-up and family planning were allocated after the procedure, and the resource requirements were analyzed. The impacts of abortion on resource requirement were further studied.
KW - HEALTH
KW - Birth control
KW - Abortion
KW - Standardization
KW - Medical care
KW - Women's health services
KW - Women
KW - Specifications
KW - Therapeutic abortion
KW - United States
N1 - Accession Number: 7971263; Williams, Stephen J. 1; McIntosh, E. Noel 2; Affiliations: 1: U.S. Public Health Service Predoctoral Fellow, Departments of Population Sciences and Health Services Administration, School of Public, Harvard University, Boston, Massachusetts 02115; 2: Assistant Professor of Population Sciences, Harvard School of Public Health, and Assistant Professor of Obstetrics and Gynecology, Harvard Medical School; Issue Info: Jul1974, Vol. 64 Issue 7, p716; Thesaurus Term: HEALTH; Thesaurus Term: Birth control; Subject Term: Abortion; Subject Term: Standardization; Subject Term: Medical care; Subject Term: Women's health services; Subject Term: Women; Subject Term: Specifications; Subject Term: Therapeutic abortion; Subject: United States; NAICS/Industry Codes: 621410 Family Planning Centers; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Belson, J. J.;
T1 - Reporting drug defects
CT - Reporting drug defects
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1974/07/01/
VL - 8
IS - Jul-Aug
SP - 21
EP - 24
SN - 03621332
AD - Product Research and Surveillance, Bureau of Drugs, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-4533; Language: English; Journal Coden: FDACBH; Section Heading: Information Processing and Literature; Abstract Author: Henri R. Manasse
N2 - The FDA Drug Product Defect Reporting System organized jointly with the USP is described. In order to focus on problems related to marketed drug products that are mislabeled, packaged poorly, not enclosed or sealed properly and not properly manufactured, the FDA in cooperation with the USP initiated a reporting system. Through the use of pharmacy practitioners and other health practitioners, problems related to defective drug products are reported to the FDA. This reporting system has enabled FDA to detect deviations from good manufacturing practices and has allowed the agency to identify industry-wide problems. In addition, the system reported has been able to provide the USP with a basis for reviewing standards for the manufacture, testing or labeling of drugs.
KW - Drug Product Defect Reporting System--description;
KW - Food and Drug Administration (U.S.)--Drug Product Defect Reporting System--description;
KW - United States Pharmacopeia--Drug Product Defect Reporting System--description;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MONATH, THOMAS P.
AU - NEWHOUSE, VERNE F.
AU - KEMP, GRAHAM E.
AU - SETZER, HENRY W.
AU - CACCIAPUOTI, ANTHONY
T1 - Lassa Virus Isolation from Mastomys natalensis Rodents during an Epidemic in Sierra Leone.
JO - Science
JF - Science
Y1 - 1974/07/19/
VL - 185
IS - 4147
M3 - Article
SP - 263
EP - 265
SN - 00368075
AB - Lassa fever is a severe febrile illness of man, first recognized in West Africa in 1969. During an epidemic in Sierra Leone, Lassa virus was isolated for the first time from wild rodents of Mastomys natalensis. A high prevalence of infected Mastomys was found in houses occupied by patients with Lassa fever. The data presented provide the first demonstration of an extra-human cycle of Lassa virus transmission and suggest that rodent control may be an eflective method of limiting the disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85117837; MONATH, THOMAS P. 1; NEWHOUSE, VERNE F. 1; KEMP, GRAHAM E. 2; SETZER, HENRY W. 3; CACCIAPUOTI, ANTHONY 4; Affiliations: 1: Vector-Borne Diseases Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, Fort Collins, Colorado 80521; 2: Tropical Diseases Laboratory, Bureau of Laboratories, Center for Disease Control, Public Health Service, San Juan, Puerto Rico 00936; 3: Division of Mammals, National Museum of Natural History, Smithsonian Institute, Washington, D.C. 20560; 4: Virology Division, Bureau of Laboratories, Center for Disease Control, Atlanta, Georgia 30333; Issue Info: 7/19/1974, Vol. 185 Issue 4147, p263; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Forman, B. H.;
AU - Feeney, E.;
AU - Boas, L.;
T1 - Drug-induced hypoglycemia
CT - Drug-induced hypoglycemia
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1974/07/29/
VL - 229
IS - Jul 29
SP - 522
AD - Public Health Service, Baltimore, Maryland
N1 - Accession Number: 11-4584; Language: English; Chemical Name: Chlorpropamide--94-20-2; Therapeutic Class: (68:20); AHFS Class: Antidiabetic agents chlorpropamide; References: 2; Publication Type: Letters; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Toxicity; Sociology, Economics and Ethics; Abstract Author: Joan Lentine
N2 - Prolonged hypoglycemia was observed in 17-year-old boy following the abuse of chlorpropamide. The patient took 500 mg. of chlorpropamide orally 3 days prior to admission to a hospital, and another 250 mg. one day later.
KW - Chlorpropamide--drug abuse-;
KW - Drug abuse--chlorpropamide--hypoglycemia, in patient;
KW - Antidiabetic agents--chlorpropamide--hypoglycemia, following abuse, in patient;
KW - Toxicity--chlorpropamide--hypoglycemia, following abuse, in patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kulkarni, S. B.;
AU - Kundaji, S. G.;
AU - Tamhane, R. G.;
T1 - Estimation of sodium citrate in pharmaceutical preparations
CT - Estimation of sodium citrate in pharmaceutical preparations
JO - Indian J. Pharm.
JF - Indian J. Pharm.
Y1 - 1974/09/01/
VL - 36
IS - Sep-Oct
SP - 120
EP - 121
AD - Drugs Control Laboratory, Food and Drug Administration, Kalanagar, Bandra (E), Bombay-51, India
N1 - Accession Number: 12-5343; Language: English; Chemical Name: Sodium citrate--6132-04-3; Therapeutic Class: (40:08); AHFS Class: Alkalinizing agents sodium citrate; Journal Coden: IJPAAO; Section Heading: Drug Analysis; Abstract Author: Judith Ann Ludy
N2 - A quantitative method for determining sodium citrate in commercial products containing ammonium chloride or sodium bicarbonate is described. The procedure consists of quantitative precipitation of citrate as calcium citrate and conversion of the isolated citrate to calcium carbonate by carbonization of a low flame before final estimation by titration with O.1 N HCl. Satisfactory analyses were obtained of 7 commercial formulations.
KW - Sodium citrate--analysis-;
KW - Analysis--sodium citrate--quantitative, in presence of ammonium chloride and sodium bicarbonate;
KW - Alkalinizing agents--sodium citrate--quantitative, in presence of ammonium chloride and sodium bicarbonate;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wolters, R. J.;
AU - Bej, A. J.;
AU - Tanner, N. S.;
T1 - Conformationally constrained analogs of mescaline
CT - Conformationally constrained analogs of mescaline
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/09/01/
VL - 63
IS - Sep
SP - 1379
EP - 1382
SN - 00223549
AD - Reprints: Food and Drug Administration, HFD-110, Rockville, Maryland 20852
AD - Dept. of Pharmaceutical Chemistry and Bionucleonics, North Dakota State Univ., Fargo, North Dakota 58102
N1 - Accession Number: 12-4085; Language: English; Chemical Name: Mescaline--54-04-6; References: 18; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Pharmacology
N2 - The syntheses of 3-(3,4,5-trimethoxyphenyl)piperidine, 2-(3,4,5-trimethoxybenzyl)piperidine, and 2-(3,4,5-trimethoxyphenyl)morpholine are described. In addition, preliminary pharmacological data in mice comparing these compounds with mescaline are given.
KW - 3-(3,4,5-Trimethoxyphenyl)piperidine--synthesis-;
KW - 2-(3,4,5-Trimethoxybenzyl)piperidine--synthesis-;
KW - 2-(3,4,5-Trimethoxyphenyl)morpholine--synthesis-;
KW - Mescaline--derivatives-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Cummings, W. B.
AU - Gaylor, D. W.
T1 - Variance Component Testing in Unbalanced Nested Designs.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1974/09//
VL - 69
IS - 347
M3 - Article
SP - 765
SN - 01621459
AB - The commonly used approximate F test for variance component testing in unbalanced nested designs was adapted from procedures developed for balanced cross classifications. However, in the unbalanced case, the analysis of variance mean squares generally are not independent or chi-square type variables, as assumed by the test procedure. Estimates of the test size disturbance introduced by employing the approximate procedure for selected unbalanced three-level nested designs indicate that the disturbances are small for a wide range of variance component ratios for extremely unbalanced design situations. Extensions to higher level unbalanced nested designs are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORRELATION (Statistics)
KW - ANALYSIS of variance
KW - MATHEMATICAL statistics
KW - REGRESSION analysis
KW - ESTIMATES
KW - EXPERIMENTAL design
N1 - Accession Number: 4612334; Cummings, W. B. 1; Gaylor, D. W. 2; Affiliations: 1: Assistant Professor, Department of Biometry, Virginia Commonwealth University, Richmond, Va. 23298.; 2: Chief, Biometry, National Center for Toxicological Research, Jefferson, Ark. 72079.; Issue Info: Sep74, Vol. 69 Issue 347, p765; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: ANALYSIS of variance; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: REGRESSION analysis; Thesaurus Term: ESTIMATES; Subject Term: EXPERIMENTAL design; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1975-04919-001
AN - 1975-04919-001
AU - Kroes, William H.
T1 - Concept shift and the development of the concept of class in children.
JF - The Journal of Genetic Psychology: Research and Theory on Human Development
JO - The Journal of Genetic Psychology: Research and Theory on Human Development
JA - J Genet Psychol
Y1 - 1974/09//
VL - 125
IS - 1
SP - 119
EP - 125
CY - US
PB - Heldref Publications
SN - 0022-1325
SN - 1940-0896
N1 - Accession Number: 1975-04919-001. Other Journal Title: The Pedagogical Seminary; The Pedagogical Seminary and Journal of Genetic Psychology. Partial author list: First Author & Affiliation: Kroes, William H.; US Public Health Service, Cincinnati, OH. Other Publishers: Taylor & Francis. Release Date: 19750301. Correction Date: 20100823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Classification (Cognitive Process); Cognitive Development; Concept Formation. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Page Count: 7. Issue Publication Date: Sep, 1974.
AB - A total of 60 kindergarten and 1st- and 2nd-grade girls were presented with 3 tasks: concept-shift, sort, and hierarchization. To check for reliability of performance, Ss were given a retest from 5 to 10 days after the 1st session, with the use of the same tasks but with slightly altered stimuli. Performance on all 3 tasks for both sessions was quite consistent; an invariance of order in task performance was found from sort to concept-shift to hierarchization. Without exception, Ss who failed a task also failed the higher-order task(s); and passing a task meant passing the lower-order task(s). Implications in relation to Piaget's theory of development of classificatory skills are given. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - concept-shift & sort & hierarchization development
KW - kindergartners
KW - & 1st- & 2nd-grade females
KW - 1974
KW - Classification (Cognitive Process)
KW - Cognitive Development
KW - Concept Formation
KW - 1974
DO - 10.1080/00221325.1974.10532309
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1975-07497-001
AN - 1975-07497-001
AU - Welches, Lois J.
AU - Dixon, F. A.
AU - Stanford, Elinor D.
T1 - Typological prediction of staff nurse performance rating.
JF - Nursing Research
JO - Nursing Research
JA - Nurs Res
Y1 - 1974/09//Sep-Oct, 1974
VL - 23
IS - 5
SP - 402
EP - 409
CY - US
PB - Lippincott Williams & Wilkins
SN - 0029-6562
SN - 1538-9847
N1 - Accession Number: 1975-07497-001. PMID: 4496810 Partial author list: First Author & Affiliation: Welches, Lois J.; US Dept of Health, Education and Welfare, US Public Health Service, San Francisco, CA. Release Date: 19750401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: California Psychological Inventory; Job Performance; Nurses; Prediction. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 8. Issue Publication Date: Sep-Oct, 1974.
AB - Based on a cluster analysis of 650 staff nurses' California Psychological Inventory scores, 6 clusters of variables that influenced performances were identified: (C1) Age and Experience; (C2) Intelligence, Independent Achievement, Sensitivity, and Flexibility; (C3) Job Satisfaction and Opportunity for Professional Growth; (C4) Perception of Self-Performance; (C5) Social Image; (C6) Leadership Potential and Capacity for Status. All but 33 of the 650 staff nurses fell into 1 of 12 O-types-each individual in a group had similar profiles on the 6 dimensions. Variables most related to the head nurse's rating of the staff nurse were in clusters C2 and C4 and the shift she was working. Among younger nurses, those who were more conforming and less ambitious received higher ratings than those who were very ambitious and somewhat rebellious. The oldest nurses in the sample received low head-nurse ratings. (16 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cluster analysis of California Psychological Inventory scores
KW - typological prediction of performance rating
KW - staff nurses
KW - 1974
KW - California Psychological Inventory
KW - Job Performance
KW - Nurses
KW - Prediction
KW - 1974
DO - 10.1097/00006199-197409000-00006
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1975-04202-001
AN - 1975-04202-001
AU - Thomas, Charles A.
T1 - Human relations training in the army medical department.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 1974/09//
VL - 139
IS - 9
SP - 731
EP - 733
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
N1 - Accession Number: 1975-04202-001. Partial author list: First Author & Affiliation: Thomas, Charles A.; US Dept of the Army, Office of the Surgeon General, Washington, DC. Release Date: 19750201. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Military Medical Personnel; Sensitivity Training; Social Sciences. Classification: Industrial & Organizational Psychology (3600); Military Psychology (3800). Population: Human (10). Page Count: 3. Issue Publication Date: Sep, 1974.
AB - Describes the evolving integration of human relations training principles into the Army Medical Department's mental health and behavioral science programs. Particular emphasis is given to how these principles contribute to an emerging broader view of mental health that incorporates social and environmental factors as contributing variables. Present human relations training activities are described, and the future utilization and importance of this approach is discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - human relations training
KW - mental health & behavioral science programs of Army Medical Department
KW - 1974
KW - Mental Health
KW - Military Medical Personnel
KW - Sensitivity Training
KW - Social Sciences
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Witte, John J.
T1 - Recent Advances in Public Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/10//
VL - 64
IS - 10
M3 - Article
SP - 939
EP - 944
PB - American Public Health Association
SN - 00900036
AB - Emphasis on immunization by United States public health agencies and medical advances, such as viral vaccine combinations, have been a major factor in reducing the morbidity and mortality of smallpox, poliomyelitis, rubella, mumps, and other communicable diseases. However, efficient delivery of immunization services has declined, as shown by increasing incidence of some diseases and a decreasing proportion of persons adequately immunized. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunization
KW - Communicable diseases
KW - Smallpox
KW - Public health -- United States
KW - Preventive medicine
KW - Medical care
KW - Viral vaccines
KW - Polio
KW - Rubella
KW - Mumps
KW - United States
KW - Health, public
N1 - Accession Number: 7971357; Witte, John J. 1; Affiliations: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, Health Services and Mental Health Administration, Center for Disease Control, Atlanta, Georgia; Issue Info: Oct1974, Vol. 64 Issue 10, p939; Thesaurus Term: Immunization; Thesaurus Term: Communicable diseases; Thesaurus Term: Smallpox; Subject Term: Public health -- United States; Subject Term: Preventive medicine; Subject Term: Medical care; Subject Term: Viral vaccines; Subject Term: Polio; Subject Term: Rubella; Subject Term: Mumps; Subject: United States; Author-Supplied Keyword: Health, public; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Judelsohn, Richard G.
T1 - Erythroblastosis: The Potential for Eradication.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/10//
VL - 64
IS - 10
M3 - Article
SP - 997
EP - 998
PB - American Public Health Association
SN - 00900036
AB - The article discusses the development of etiology, pathogenesis and management of erythroblastosis fetalis in the U.S. The hemolytic disease of the newborn was considered a significant cause of perinatal morbidity and mortality. Several attempts to prevent the disease had begun in 1960 by injecting anti-Rh antibody into Rh-positive red blood cells which prevented the formation of the Rh antibody responsible for the disease. In 1968, Rh immune globulin became available as a licensed product, however, the continuous death rate of newborns increases due to lack of awareness and the growth of abortions.
KW - DISEASES
KW - Erythroblastosis fetalis
KW - Newborn infants
KW - Neonatal mortality
KW - Perinatal death
KW - Hemolytic anemia
KW - Rho(D) immune globulin
KW - RH factor
KW - Perinatology
KW - United States
KW - Blood
KW - Disease eradication
KW - Erythroblastosis
N1 - Accession Number: 7971348; Judelsohn, Richard G. 1; Affiliations: 1: U.S. Department of Health, Education, and Welfare, Public Health Service Health Services and Mental Health Administration, Center for Disease Control, Epidemiology Program, Field Services Branch, Atlanta, Georgia; Issue Info: Oct1974, Vol. 64 Issue 10, p997; Thesaurus Term: DISEASES; Subject Term: Erythroblastosis fetalis; Subject Term: Newborn infants; Subject Term: Neonatal mortality; Subject Term: Perinatal death; Subject Term: Hemolytic anemia; Subject Term: Rho(D) immune globulin; Subject Term: RH factor; Subject Term: Perinatology; Subject: United States; Author-Supplied Keyword: Blood; Author-Supplied Keyword: Disease eradication; Author-Supplied Keyword: Erythroblastosis; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Ment, W. M.;
AU - Naviasky, H. S.;
T1 - Effect of maleic acid in compendial UV absorption assays for antihistamine maleate salts
CT - Effect of maleic acid in compendial UV absorption assays for antihistamine maleate salts
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/10/01/
VL - 63
IS - Oct
SP - 1604
EP - 1609
SN - 00223549
AD - Food and Drug Administration, 900 Madison Ave., Baltimore, Maryland 21201
N1 - Accession Number: 12-4098; Language: English; Chemical Name: Maleic acid--110-16-7; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Maleic acid--spectrometry, ultraviolet-;
KW - Antihistamines--maleates--spectrometry, ultraviolet, effects, maleic acid;
KW - Spectrometry, ultraviolet--antihistamines--maleates, effects, maleic acid;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1975-08866-001
AN - 1975-08866-001
AU - Buchsbaum, Monte
AU - Coppola, Richard
AU - Bittker, Thomas E.
T1 - Differential effects of 'congruence,' stimulus meaning, and information on early and late components of the average evoked response.
JF - Neuropsychologia
JO - Neuropsychologia
JA - Neuropsychologia
Y1 - 1974/10//
VL - 12
IS - 4
SP - 533
EP - 544
CY - Netherlands
PB - Elsevier Science
SN - 0028-3932
N1 - Accession Number: 1975-08866-001. PMID: 4437750 Partial author list: First Author & Affiliation: Buchsbaum, Monte; NIMH Public Health Service, Bethesda, MD. Release Date: 19750501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Expectations; Meaning; Stimulus Variability; Visual Evoked Potentials. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Page Count: 12. Issue Publication Date: Oct, 1974.
AB - Visual average evoked responses (AERs) were studied in situations where Ss expected after training that a different stimulus intensity would occur, or misperceived the actual intensity of the stimulus. In Exp I 15 paid female young adults were taught a simple temporal pattern of light intensities. After repeated presentation of a simple pattern of lights, Ss tended to view more complex patterns as if they were a continuation of the preceding simpler pattern. In Exp II with 36 young adult volunteers, when Ss erred in an absolute intensity judgment task, their AERs to the misperceived stimulus had an amplitude either larger or smaller depending on the direction of the S's error. This tendency to produce AERs consistent with what the S expected was reflected significantly in the early but not late components of the S's AER. Termed the 'congruence illusion,' the effect is hypothesized to be a means of protection against stimulus overload. The congruence illusion was eliminated by providing Ss with sufficient details of a complex pattern. Stimulus meaning effects were reflected principally in early components, while information value and contrast effects were confined to later components. (French & German summaries) (22 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - congruence & stimulus meaning & information
KW - early & late components of average evoked response
KW - 1974
KW - Expectations
KW - Meaning
KW - Stimulus Variability
KW - Visual Evoked Potentials
KW - 1974
DO - 10.1016/0028-3932(74)90084-0
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Gunn, B. A.;
AU - Woodall, J. B.;
AU - Jones, J. F.;
AU - Thronsberry, C.;
T1 - Ampicillin resistant Haemophilus influenzae
CT - Ampicillin resistant Haemophilus influenzae
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1974/10/05/
VL - 2
IS - Oct 5
SP - 845
SN - 00237507
AD - Center for Disease Control, Public Health Service, Dept. of HEW, Atlanta, Georgia 30333
N1 - Accession Number: 12-0901; Language: English; Chemical Name: Ampicillin--69-53-4; References: 5; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Microbiology; Abstract Author: Joan Lentine
N2 - An ampicillin-resistant strain of Haemophilus influenzae was reported in a 2-year-old boy who lived in Germany.
KW - Ampicillin--resistance-;
KW - Resistance--ampicillin--Haemophilus influenzae, in child;
KW - Haemophilus influenzae--resistance--ampicillin, in child;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lane, J. R.;
AU - McClure, F.;
AU - Martinez, C.;
T1 - Evaluation of an automated dual-channel hydroxylamine assay procedure for formulated penicillin products. 1. Liquid formulations
CT - Evaluation of an automated dual-channel hydroxylamine assay procedure for formulated penicillin products. 1. Liquid formulations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/11/01/
VL - 57
IS - Nov
SP - 1314
EP - 1324
AD - National Center for Antibiotic Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 13-0831; Language: English; Chemical Name: Penicillin--1406-05-9 Oxacillin--66-79-5 Ampicillin--69-53-4 Penicillin G--61-33-6; References: 11; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The automated dual-channel hydroxylamine method was compared with the official FDA manual iodometric method used to determine the potency of formulated penicillin products. In order to assay a wide range of products, the liquid sampler module was used with 4 different flow diagram arrangements for liquid sample solutions. Some dosage forms were assayed directly from their pharmaceutical market containers via on-line dilution techniques. Some of the problems encountered are described and experimental design as well as methods of statistical analysis are discussed. The method reported has been recommended as an alternative to the official FDA manual procedure. In general, the automated hydroxylamine method compared well in accuracy and precision with the manual iodometric method. Manually diluted autoanalysis lacked the precision of other methods. Drugs analyzed included penicillin V, procaine and potassium penicillin G, ampicillin trihydrate, and oxacillin sodium.
KW - Penicillin--derivatives-;
KW - Oxacillin--colorimetry-;
KW - Ampicillin--trihydrate-;
KW - Penicillin G--procaine-;
KW - Colorimetry--penicillin--derivatives, automated dual-channel hydroxylamine assay for solutions and reconstituted powders;
KW - Dosage forms--penicillin--derivatives, colorimetry, automated dual-channel hydroxylamine assay for solutions and reconstituted powders;
KW - Solutions--penicillin--derivatives, automated dual-channel hydroxylamine assay;
KW - Iodimetry--penicillin--derivatives, comparison, colorimetry, automated dual-channel hydroxylamine assay for solutions and reconstituted powders;
KW - Colorimetry--penicillin--derivatives, automated dual-channel hydroxylamine assay for solutions and reconstituted powders;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lane, J. R.;
T1 - Evaluation of an automated dual-channel hydroxylamine assay procedure for formulated penicillin products. 2. Intact solid dosage formulations
CT - Evaluation of an automated dual-channel hydroxylamine assay procedure for formulated penicillin products. 2. Intact solid dosage formulations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1974/11/01/
VL - 57
IS - Nov
SP - 1325
EP - 1337
AD - National Center for Antibiotic Analysis, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 13-0525; Language: English; Chemical Name: Nafcillin--147-52-4 Oxacillin--66-79-5 Penicillin V--87-08-1 Penicillin G--61-33-6 Penicillin--1406-05-9 Ampicillin--69-53-4 Cloxacillin--61-72-3 Dicloxacillin--3116-76-5; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The dual-channel hydroxylamine method for the potency determination of formulated penicillins has been evaluated for use as an official FDA alternative assay method for solid dosage formulations. A modified Technicon SOLIDprep Sampler I was used to assay a wide range of penicillin capsules and compressed tablets. In some instances, as many as 10 tablets/sample cup were tested. Results by this method and the official FDA manual method are compared. Some of the problems encountered in the analysis of ampicillin trihydrate capsule formulations and with compressed, film coated tablets are also described. Based on the performance of the automated system and the data obtained, recommendations have been made to make the dual-channel hydroxylamine procedure an official FDA alternative assay. Penicillins analyzed included sodium cloxacillin monohydrate, sodium dicloxacillin monohydrate, sodium nafcillin monohydrate, potassium penicillin G, penicillin V and sodium oxacillin.
KW - Nafcillin--colorimetry-;
KW - Oxacillin--colorimetry-;
KW - Penicillin V--colorimetry-;
KW - Penicillin G--colorimetry-;
KW - Penicillin--derivatives-;
KW - Ampicillin--trihydrate-;
KW - Cloxacillin--colorimetry-;
KW - Dicloxacillin--colorimetry-;
KW - Colorimetry--penicillin--derivatives, automated dual-channel hydroxylamine assay for solid dosage forms;
KW - Dosage forms--penicillin--derivatives, colorimetry, automated dual-channel hydroxylamine assay;
KW - Tablets--ampicillin--trihydrate, colorimetry, automated dual-channel hydroxylamine assay;
KW - Capsules--ampicillin--trihydrate, colorimetry, automated dual-channel hydroxylamine assay;
KW - Tablets--penicillin--derivatives, colorimetry, automated dual-channel hydroxylamine assay;
KW - Capsules--penicillin--derivatives, colorimetry, automated dual-channel hydroxylamine assay;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-0525&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Dunham, L. J.;
AU - Sheets, R. H.;
AU - Morton, J.;
T1 - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
CT - Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles
JO - Journal of the National Cancer Institute (USA)
JF - Journal of the National Cancer Institute (USA)
Y1 - 1974/11/01/
VL - 53
IS - Nov
SP - 1259
EP - 1269
SN - 00278874
AD - Laboratory of Pathology, NIH, National Cancer Institute, Dept. of Health, Education, and Public Health Service, U.S. Dept. of Health Education and Welfare, Bethesda, Maryland 20014
N1 - Accession Number: 12-4232; Language: English; Chemical Name: Arecoline--63-75-2; References: 28; Section Heading: Toxicity; Pharmacognosy
N2 - Attempts were made to develop a reliable test for the presence or absence of carcinogens in the environment. Certain plant materials suspected of affecting the development of esophageal cancer in man were applied to hamsters' upper GI tract, including cheek pouch, in several long term experiments. The materials tested, often with calcium hydroxide added, were 9 plants from Curacao used in native teas and remedies, a tobacco (used in snuff), and arecoline, present in betel quid. Lesions developing after treatment with \IT/Annona muricata, Heliotropium ternatum, Krameria ixina,\OK/ and \IT/Acacia villosa,\OK/ and with arecoline were a superficial spreading carcinoma of pouch epithelium, papillomas of esophagus (4) and advanced atypias (1 in pouch, 3 in esophagus). These lesions developed in relation to the cheeck pouch route of application only, whereas none resulted after ingestion of a concentrated tea (\IT/A. villosa\OK/), or when administered in the diet (\IT/A. muricate,\OK/ arecoline). The histologic types and distribution of the lesions in cheek pouch and esophagus suggest that they were caused by substances in the test materials tentatively presumed to be weaker or slower in action than the known chemical carcinogens.
KW - Arecoline--carcinogens-;
KW - Annona muricata--carcinogens--lesions, in hamster cheek pouch;
KW - Acacia villosa--carcinogens--lesions, in hamster cheek pouch;
KW - Heliotropium ternatum--carcinogens--lesions, in hamster cheek pouch;
KW - Krameria ixina--carcinogens--lesions, in hamster cheek pouch;
KW - Carcinogens--plants--Curacao, lesions, in hamster cheek pouch;
KW - Folk medicine--plants--Curacao, teas and remedies, carcinogens, in hamster cheek pouch;
KW - Toxicity--plants--Curacao, teas, remedies, lesions in hamster cheek pouch;
KW - Methodology--carcinogens--plants, detection using hamsters, cheek pouch lesions;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-4232&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1977-04039-001
AN - 1977-04039-001
AU - Bergman, Robert L.
T1 - Paraprofessionals in Indian mental health programs.
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 1974/11//
VL - 4
IS - 11
SP - 76
EP - 84
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
N1 - Accession Number: 1977-04039-001. Partial author list: First Author & Affiliation: Bergman, Robert L.; Indian Health Service, Albuquerque, NM. Release Date: 19770201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Mental Health Programs; Paraprofessional Personnel. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 9. Issue Publication Date: Nov, 1974.
AB - States that the mental health program of the Indian Health Service (IHS) is completely dependent on its Indian paraprofessionals. The advantages of using them include the establishment of communication, improved understanding, and facilitation of treatment, and are illustrated by case examples from experience with the Navahos particularly. Recruitment is not difficult, since every Indian community includes men and women who are skilled in talking to people about personal problems. Paraprofessionals have been especially useful in bringing Navaho patients home from the state hospitals to their own communities and in helping them to live there. Difficulties in employing Indian paraprofessionals have included hostility, ignorance, suspicion, anxiety caused by cultural differences, and bureaucratic procedures. The language barrier was serious until White professionals became willing to let paraprofessionals conduct interviews in Navaho. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - advantages of Indian Health Service's dependence on Indian paraprofessionals
KW - 1974
KW - American Indians
KW - Mental Health Programs
KW - Paraprofessional Personnel
KW - 1974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1977-04039-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1977-04270-001
AN - 1977-04270-001
AU - Goldstein, George S.
T1 - The model dormitory.
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 1974/11//
VL - 4
IS - 11
SP - 85
EP - 92
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
N1 - Accession Number: 1977-04270-001. Partial author list: First Author & Affiliation: Goldstein, George S.; Indian Health Service, Mental Health Programs, Albuquerque, NM. Release Date: 19770201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Dormitories; Emotional Adjustment; Intellectual Development; Physical Development. Minor Descriptor: Surrogate Parents (Humans). Classification: Educational Psychology (3500). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Page Count: 8. Issue Publication Date: Nov, 1974.
AB - Describes the gross deficiences of the boarding-school dormitories housing Indian children, which include overcrowding, understaffing, lack of sensitivity and stimulation, and many other defects. To provide concrete evidence that children would benefit from having more and better surrogate parents, the Model Dormitory Project was set up in 1969 with Navaho children. No changes in physical facilities were made, but 32 additional houseparents were employed, all Navaho-speaking, and warm friendly interaction between them and the children was encouraged. A 3-yr evaluation procedure was in effect from the beginning, and children were measured for intellectual development, emotional adjustment, and physical development. Comparison with a matched group of children in a dormitory operated along conventional lines showed striking results in favor of the model dormitory. Scores on almost every measure used (some standard tests could not be applied with Navaho children) indicated that the model dormitory had a positive effect. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Model Dormitory Project
KW - with additional Navaho-speaking houseparents
KW - intellectual & physical development & emotional adjustment
KW - Navaho-speaking children
KW - 1974
KW - American Indians
KW - Dormitories
KW - Emotional Adjustment
KW - Intellectual Development
KW - Physical Development
KW - Surrogate Parents (Humans)
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1975-06906-001
AN - 1975-06906-001
AU - Christman, C. L.
T1 - A digital sequential generator for implementing reinforcement schedules.
JF - Journal of the Experimental Analysis of Behavior
JO - Journal of the Experimental Analysis of Behavior
JA - J Exp Anal Behav
Y1 - 1974/11//
VL - 22
IS - 3
SP - 577
EP - 580
CY - US
PB - Journal of the Experimental Analysis of Behavior
SN - 0022-5002
SN - 1938-3711
N1 - Accession Number: 1975-06906-001. PMID: 16811822 Partial author list: First Author & Affiliation: Christman, C. L.; US Public Health Service, Rockville, MD. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19750401. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Generators (Apparatus); Reinforcement Schedules. Classification: Animal Experimental & Comparative Psychology (2400). Population: Human (10). Page Count: 4. Issue Publication Date: Nov, 1974.
KW - digital sequential generator
KW - implementation of reinforcement schedules
KW - 1974
KW - Generators (Apparatus)
KW - Reinforcement Schedules
KW - 1974
DO - 10.1901/jeab.1974.22-577
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1975-06906-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1975-05843-001
AN - 1975-05843-001
AU - Albaugh, Bernard J.
AU - Anderson, Philip O.
T1 - Peyote in the treatment of alcoholism among American Indians.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1974/11//
VL - 131
IS - 11
SP - 1247
EP - 1250
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1975-05843-001. PMID: 4424469 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Albaugh, Bernard J.; US Public Health Service Indian Hosp, Clinton, OK. Release Date: 19750301. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcoholism; American Indians; Occupational Therapy; Peyote; Psychotherapeutic Techniques. Minor Descriptor: Drug Rehabilitation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 4. Issue Publication Date: Nov, 1974.
AB - Examined the development and effectiveness of a treatment program for alcoholism among American Indians. This program offers the alcoholic Indian both occupational and cultural therapy, including participation in the services of the Native American Church (peyote meetings). During these meetings, participants often ingest peyote (mescaline), which, like LSD, facilitates cathartic expression and enhances suggestibility. Although peyote meetings are not a cure for alcoholism, they do offer some specific advantages in the treatment of the unique problems of the Indian alcoholic. (20 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - peyote & occupational & cultural therapy
KW - alcoholism treatment
KW - American Indians
KW - 1974
KW - Alcoholism
KW - American Indians
KW - Occupational Therapy
KW - Peyote
KW - Psychotherapeutic Techniques
KW - Drug Rehabilitation
KW - 1974
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Levy, L.;
T1 - Pharmacologic studies of clofazimine
CT - Pharmacologic studies of clofazimine
JO - Am. J. Trop. Med. Hyg.
JF - Am. J. Trop. Med. Hyg.
Y1 - 1974/12/01/
VL - 23
IS - Dec
SP - 1097
EP - 1109
AD - Leprosy Research Unit, Public Health Service Hospital, San Francisco, California 94118
N1 - Accession Number: 12-5003; Language: English; Chemical Name: Clofazimine--2030-63-9; Therapeutic Class: (8:00); AHFS Class: Antileprotic agents clofazimine; References: 25; Journal Coden: AJTHAB; Human Indicator: Yes; Section Heading: Pharmacology
N2 - Clofazimine (B-663) pharmacology was studied in mice and humans in order to provide information needed for interpretation of drug action data obtained from the 2 species.
KW - Clofazimine--antileprotic agents-;
KW - Antileprotic agents--clofazimine--pharmacology, in mice and humans;
KW - Half-life--clofazimine--in mice and humans;
KW - Metabolism--clofazimine--in mice and humans;
KW - Drugs, body distribution--clofazimine--in mice and in humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5003&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mansfield, R. E.;
T1 - Tissue concentrations of clofazimine (B-663) in man
CT - Tissue concentrations of clofazimine (B-663) in man
JO - Am. J. Trop. Med. Hyg.
JF - Am. J. Trop. Med. Hyg.
Y1 - 1974/12/01/
VL - 23
IS - Dec
SP - 1116
EP - 1119
AD - Laboratory Branch, Public Health Service Hospital, Carville, Louisiana 70721) (Reprints: Dept. of Pathology, Graham Hospital Association, Canton, Illinois 61520
N1 - Accession Number: 12-4486; Language: English; Trade Name: B-663; Generic Name: Clofazimine; Chemical Name: Clofazimine--2030-63-9; Therapeutic Class: (8:00); AHFS Class: Antileprotic agents clofazimine; References: 19; Journal Coden: AJTHAB; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Investigational Drugs
N2 - Tissue levels of clofazimine were studied in 3 leprosy patients at autopsy and a skin biopsy was studied in another patient. Highest concentrations were observed in tissues with high fat content and in the bile. Tissues with a reticuloendothelial component or high vascularity also showed relatively high concentrations. High levels were present also in the liver and in the gall bladder.
KW - Clofazimine--tissue levels-;
KW - Tissue levels--clofazimine--in leprosy patients;
KW - Drugs, body distribution--clofazimine--tissue levels, in leprosy patients;
KW - Antileprotic agents--clofazimine--tissue levels, in patients;
KW - Metabolism--clofazimine--body distribution, in leprosy patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
AU - Fazzari, F. R.;
T1 - Determination of drugs in dosage forms by difference spectrophotometry
CT - Determination of drugs in dosage forms by difference spectrophotometry
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1974/12/01/
VL - 63
IS - Dec
SP - 1921
EP - 1926
SN - 00223549
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 12-4097; Language: English; References: 11; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - This paper reports the difference spectrophotometric assay of numerous acidic, basic, and amphoteric drug substances. The technique was applied to the rapid assay of numerous pharmaceuticals, without prior separation from other materials.
KW - Spectrometry--difference--dosage forms;
KW - Dosage forms--spectrometry--difference;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheppard, E. P.;
AU - Wilson, C. H.;
T1 - Fluorometric determination of formaldehyde-releasing cosmetic preservatives
CT - Fluorometric determination of formaldehyde-releasing cosmetic preservatives
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1974/12/01/
VL - 25
IS - Dec
SP - 655
EP - 666
SN - 00379832
AD - Div. of Cosmetics Technology, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-4647; Language: English; Trade Name: Germall 115--Methane bis[N,N\PR/-(5-ureido-2,4-diketotetrahydroimidazole)-N,N\PR/- dimethylol]--Bronopol; Generic Name: Imidurea; Imidurea; 2-Nitro-2-bromo-1,3-propanediol; Chemical Name: Formaldehyde--50-00-0 Imidurea--39236-46-9; References: 4; Journal Coden: JSCCA5; Section Heading: Drug Evaluations
N2 - The preservatives, 2-nitro-2-bromo-1,3-propanediol (I; Bronopol), 1-hydroxymethyl-5,5-dimethylhydantoin (II), and methane bis [(N,N\PR/-(5-ureido-2,4-diketotetrahydroimidazole)-N,N\PR/- dimethylol] (III; Germall 115; Imidurea) contain hydroxymethylene functional groups which oxidize to formaldehyde which can be analyzed fluorometrically. Formaldehyde released was reacted with 2,4-pentanedione and ammonia to produce 3,5-diacetyl-1,4-dihydrolutidine which was measured by fluorometry. Using this technique, the preservatives were determined in cosmetics with average recoveries ranging from 96 to 106%. Formaldehyde was released quantitatively from II. About 50% of the theoretical yield was obtained from III. Formaldehyde derived from I was highly dependent on temperature and at 60\DG/C an average value of 28% of theoretical was obtained.
KW - Formaldehyde--release-;
KW - 2-Nitro-2-bromo-1,3-propanediol--fluorometry-;
KW - 1-Hydroxymethyl-5,5-dimethylhydantoin--fluorometry-;
KW - Imidurea--fluorometry-;
KW - Preservatives--cosmetics--fluorometry;
KW - Fluorometry--preservatives--cosmetics;
KW - Cosmetics--preservatives--fluorometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Done, A. K.;
T1 - Salicylate, pharmacokinetics, and the pediatrician
CT - Salicylate, pharmacokinetics, and the pediatrician
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1974/12/01/
VL - 54
IS - Dec
SP - 670
EP - 672
SN - 00314005
AD - Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 13-1768; Language: English; References: 11; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Abstract Author: Brenda Sue Martinez
N2 - Accidental salicylate (I) poisoning, and poisoning from other similarly protein bound drugs, offer an excellent opportunity for the study of pediatric pharmacokinetic parameters. The unusual drug distribution of I may be shared by other drugs that are similarly protein bound, especially when the drug levels achieved exceed the binding capacity of available serum proteins. The clinical severity of I poisoning in cases of single dose acute ingestion correlates poorly with the serum I concentration at a given time, but well with the peak serum level because the apparent volume of distribution increases with higher doses. Acidosis accentuates I penetration into the brain and other tissues. Steady control of acidosis by continuous bicarbonate infusion may be preferred to intermittent alkali or alkalinization of the urine. Since one determinant of expanded I distribution with large doses is oversaturation of albumin binding sites, it may be worthwhile to infuse albumin. Albumin containing peritoneal dialysis solutions are more efficient than clear ones.
KW - Salicylates--poisoning--blood levels, body distribution, and therapy, in children;
KW - Poisoning--salicylates--blood levels, body distribution, and therapy, in children;
KW - Toxicity--salicylates--poisoning, blood levels, body distribution, and therapy, in children;
KW - Blood levels--salicylates--poisoning, body distribution, and therapy, in children;
KW - Drugs, body distribution--salicylates--poisoning, blood levels, and therapy, in children;
KW - Metabolism--salicylates--poisoning, blood levels, body distribution, and therapy, in children;
KW - Binding--salicylates--albumin, human serum, in children;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1768&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Shroff, A. P.;
AU - Baily, L. C.;
AU - Scheer, I.;
T1 - Gas chromatographic determination of fenestrel in serum
CT - Gas chromatographic determination of fenestrel in serum
JO - Res. Commun. Chem. Pathol. Pharmacol.
JF - Res. Commun. Chem. Pathol. Pharmacol.
Y1 - 1974/12/01/
VL - 9
IS - Dec
SP - 661
EP - 672
AD - Analytical Research Group, Div. of Chemical Research, Ortho Research Foundation, Raritan, New Jersey 08869) (Reprints: Food and Drug Administration, 5600 Fisher's Lane, Rockville, Maryland
N1 - Accession Number: 12-1633; Language: English; Trade Name: 2-Methyl-3-ethyl-4-phenyl-4-cyclohexenecarboxylic acid--ORF-3858; Generic Name: Fenestrel; Fenestrel; References: 4; Journal Coden: RCOCB8; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2 - A gas chromatographic method is described for the quantitation of fenestrel (2-methyl-3-ethyl-4-phenyl-4-cyclohexenecarboxylic acid) in rabbit and humans sera. Upon extraction with hexane from acidified serum, the compound is analyzed by using a flame ionization detector. Quantitation is achieved using a standard curve. The analysis is sensitive to amounts of the drug above 0.5 mcg./ml. Recovery averaged 95.8%. Serum data are presented to demonstrate the utility of the method.
KW - Fenestrel--chromatography, gas-;
KW - Chromatography, gas--fenestrel--blood levels, in rabbits and humans;
KW - Blood levels--fenestrel--chromatography, gas, in rabbits and humans;
KW - Metabolism--fenestrel--blood levels, chromatography, gas, in rabbits and humans;
KW - Antifertility agents--fenestrel--blood levels, chromatography, gas, in animals and humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1633&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Greene, Mark H.
T1 - An Epidemiologic Assessment of Heroin Use.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1974/12/05/Dec1974 Supplement
VL - 64
M3 - Article
SP - 1
EP - 10
PB - American Public Health Association
SN - 00900036
AB - The validity and utility of the epidemiologic approach to studying heroin use are examined in detail, with particular emphasis on the analogy between heroin use and communicable disease. The rationale for designating heroin use an epidemic phenomenon, the role of the psychosocial model of addiction, and new drug abuse surveillance and intervention techniques are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology -- Research
KW - Epidemics
KW - Narcotics
KW - Communicable diseases
KW - Heroin
KW - Drug abuse
KW - Drug addiction
KW - Epidemiologists
KW - Medical personnel
KW - Drugs
KW - Epidemiology
KW - Health
KW - Heroin use
N1 - Accession Number: 7971416; Greene, Mark H. 1; Affiliations: 1: Epidemic Intelligence Service Officer, Department of Health, Education, and Welfare, U.S. Public Health Service, Center for Disease Control, Atlanta, Georgia 30333; Issue Info: Dec1974 Supplement, Vol. 64, p1; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: Epidemics; Thesaurus Term: Narcotics; Thesaurus Term: Communicable diseases; Subject Term: Heroin; Subject Term: Drug abuse; Subject Term: Drug addiction; Subject Term: Epidemiologists; Subject Term: Medical personnel; Author-Supplied Keyword: Drugs; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Health; Author-Supplied Keyword: Heroin use; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Slavin, M
T1 - Food and drug administration drug registration and listing system
JO - Drug Information Journal 9, 239-240 (1975 May-september)
JF - Drug Information Journal 9, 239-240 (1975 May-september)
Y1 - 1975///
M3 - Book Chapter
AB - A summarization of the implementation and association problems of the drug listing act of 1972 (registration of drug manufacturers and listing of all durgs in distribution, each drug to have a national drug code (ndc) number) are presented.
N1 - Accession Number: ISTA1201869; Slavin, M 1; Affiliations: 1 : Division Of Data Management, Bureau Of Drugs, Food And Drug Administration, Rockville, Maryland; Source Info: 1975; Note: Update Code: 1200; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Bhetasiwala, D. Y.;
AU - Mehta, K. M.;
AU - Tamhane, R. G.;
T1 - Estimation of diphenhydramine hydrochloride in expectorants in presence of chlorpheniramine maleate
CT - Estimation of diphenhydramine hydrochloride in expectorants in presence of chlorpheniramine maleate
JO - Indian J. Pharm.
JF - Indian J. Pharm.
Y1 - 1975/01/01/
VL - 37
IS - Jan-Feb
SP - 15
EP - 16
AD - Drugs Control Laboratory, Food and Drug Administration, Maharashtra State, Bombay - 51, India
N1 - Accession Number: 13-0191; Language: English; Chemical Name: Diphenhydramine--58-73-1; Therapeutic Class: (48:00); AHFS Class: Expectorants and cough preparations diphenhydramine; Journal Coden: IJPAAO; Section Heading: Drug Analysis; Abstract Author: Judith Ann Ludy
N2 - A colorimetric assay method is described for the estimation of diphenhydramine (I) in expectorants also containing chlorpheniramine (II) The determination depends upon the formation of a water-insoluble reineckate complex with I at pH of about 10. After washing, the complex is redissolved with acetone, and its concentration is measured colorimetrically at 525nm. II does not interfere as a similar insoluble complex is not formed.
KW - Diphenhydramine--colorimetry-;
KW - Expectorants and cough preparations--diphenhydramine--colorimetry, in presence of chlorpheniramine;
KW - Colorimetry--diphenhydramine--in presence of chlorpheniramine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
T1 - High pressure liquid chromatographic determination of uncombined intermediates and subsidiary colors in FD&C Blue No. 2
CT - High pressure liquid chromatographic determination of uncombined intermediates and subsidiary colors in FD&C Blue No. 2
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/01/01/
VL - 58
IS - Jan
SP - 48
EP - 49
AD - Div. of Color Technology, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-4748; Language: English; Trade Name: Indigotine; Generic Name: FD&C Blue No. 2; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A high pressure liquid chromatographic method is presented for the isolation and determination on uncombined intermediates and subsidiary colors in FD&C Blue No. 2 (indigotine).
KW - FD&C Blue No. 2--chromatography, liquid-;
KW - Chromatography, liquid--FD&C Blue No. 2--high pressure, uncombined intermediates and subsidiary colors;
KW - Dyes--FD&C Blue No. 2--chromatography, liquid, high pressure, uncombined intermediates and subsidiary colors;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Juhl, W. E.;
T1 - Collaborative study of a semiautomated colorimetric analysis of digoxin tablets
CT - Collaborative study of a semiautomated colorimetric analysis of digoxin tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/01/01/
VL - 58
IS - Jan
SP - 70
EP - 74
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 12-4744; Language: English; Chemical Name: Digoxin--20830-75-5; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs digoxin; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A semiautomated thiobarbituric acid colorimetric analysis for digoxin tablets was collaboratively studied by 6 laboratories. Collaborators were supplied with 3 composites of tablets of different dosage levels. Results agreed with the USP method. The coefficients of variation ranged from 0.46 to 2.73%.
KW - Digoxin--colorimetry-;
KW - Cardiac drugs--digoxin--tablets, semiautomated thiobarbituric acid colorimetric analysis;
KW - Colorimetry--digoxin--tablets, semiautomated thiobarbituric acid analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wu, J. Y.;
T1 - Colorimetric determination of mestranol in combination with ethynodiol diacetate
CT - Colorimetric determination of mestranol in combination with ethynodiol diacetate
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/01/01/
VL - 58
IS - Jan
SP - 75
EP - 79
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-4746; Language: English; Chemical Name: Mestranol--72-33-3; Therapeutic Class: (68:12); AHFS Class: Contraceptives, oral mestranol, combination, ethynodiol (68:12); AHFS Class: Contraceptives, oral ethynodiol, combination, mestranol; References: 21; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Mestranol in combination with ethynodiol diacetate, is isolated from the sample on a partition chromatographic column prior to colorimetric determination. The color reaction which is specific for estrogens is formed by shaking an aliquot of the heptane eluate of mestranol with a 30% methanol-sulfuric acid solution. A collaborative study of the method gave results of 99.8% of added mestranol for the simulated mix and 100.7% of labeled mestranol for the commercial tablet.
KW - Mestranol--combination, ethynodiol-;
KW - Ethynodiol--combination, mestranol-;
KW - Colorimetry--mestranol, combination, ethynodiol--tablets, following column chromatography;
KW - Chromatography, column--mestranol, combination, ethynodiol--tablets, and colorimetry;
KW - Chromatography, column--ethynodiol, combination, mestranol--tablets, and colorimetry;
KW - Colorimetry--ethynodiol, combination, mestranol--tablets, following column chromatography;
KW - Contraceptives, oral--mestranol, combination, ethynodiol--tablets, colorimetry following column chromatography;
KW - Contraceptives, oral--ethynodiol, combination, mestranol--tablets, colorimetry following column chromatography;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kolinski, R. E.;
T1 - Collaborative study of a semiautomated method for the analysis of acenocoumarol, phenprocoumon, and potassium warfarin tablets
CT - Collaborative study of a semiautomated method for the analysis of acenocoumarol, phenprocoumon, and potassium warfarin tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/01/01/
VL - 58
IS - Jan
SP - 80
EP - 84
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 12-4745; Language: English; Chemical Name: Acenocoumarol--152-72-7 Phenprocoumon--435-97-2 Warfarin--81-81-2; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - This collaborative study was undertaken to determine if the anticoagulants acenocoumarol (I), phenprocoumon (II), and potassium warfarin (III) could be analyzed by the automated UV spectrophotometric system described in a collaborative study for the analysis of sodium warfarin and dicumarol. Collaborators were supplied with a composited tablet sample of each anticoagulant. Results agreed well with the NF methods for II and III and an unpublished method for I. Coefficients of variation on individual sets of data ranged from 0.30-1.94% for I, from 0.52-1.20% for II, and from 0.54-1.79% for III.
KW - Acenocoumarol--spectrometry, ultraviolet-;
KW - Phenprocoumon--spectrometry, ultraviolet-;
KW - Warfarin--spectrometry, ultraviolet-;
KW - Spectrometry, ultraviolet--acenocoumarol--automated, tablets;
KW - Spectrometry, ultraviolet--phenprocoumon--automated, tablets;
KW - Spectrometry, ultraviolet--warfarin--automated, tablets;
KW - Anticoagulants--spectrometry, ultraviolet--tablets, automated method;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D;
AU - Proctor, J. B.;
T1 - Determination of procaine and related local anesthetics. 1. Partition chromatographic separation and assay of mixtures of procaine with tetracaine and with propoxycaine. 2. And collaborative study
CT - Determination of procaine and related local anesthetics. 1. Partition chromatographic separation and assay of mixtures of procaine with tetracaine and with propoxycaine. 2. And collaborative study
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/01/01/
VL - 58
IS - Jan
SP - 88
EP - 94
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-4747; Language: English; Chemical Name: Procaine--59-46-1 Tetracaine--94-24-6; Therapeutic Class: (72:00); AHFS Class: Anesthetics, local procaine, combination, propoxycaine or tetracaine (72:00); AHFS Class: Anesthetics, local tetracaine, combination, procaine (72:00); AHFS Class: Anesthetics, local propoxycaine, combination, procaine; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Determination of ionization and extraction constants for procaine, tetracaine, and propoxycaine led to selection of a simple partition chromotographic system for separation and assay of mixtures of these anesthetics. A 65% solution of chloroform in isoctane elutes tetracaine or propoxycaine from a pH 4 sodium bromide column; procaine is retained and subsequently eluted by chloroform as the bromide ion pair. The anesthetics are then determined by UV spectrometry. Results of assay of standard and commercial injectable formulations are presented. The method provides for the removal of phenolic vasoconstrictors and parabens.
KW - Procaine--combination, propoxycaine or tetracaine-;
KW - Tetracaine--combination, procaine-;
KW - Propoxycaine--combination, procaine-;
KW - Anesthetics, local--procaine, combination, propoxycaine or tetracaine--chromatography, column, and UV spectrometry;
KW - Anesthetics, local--tetracaine, combination, procaine--chromatography, column, and UV spectrometry;
KW - Anesthetics, local--propoxycaine, combination, procaine--chromatography, column, and UV spectrometry;
KW - Spectrometry, ultraviolet--anesthetics, local--following column chromatography;
KW - Chromatography, column--anesthetics, local--and UV spectrometry;
KW - Injections--anesthetics, local--chromatography, column, and UV spectrometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haley, T. J.;
T1 - Vinyl chloride: how many unknown problems?
CT - Vinyl chloride: how many unknown problems?
JO - J. Toxicol. Environ. Health
JF - J. Toxicol. Environ. Health
Y1 - 1975/01/01/
VL - 1
IS - Jan
SP - 47
EP - 73
AD - National Center for Toxicological Research, Jefferson, Arkansas 72079
N1 - Accession Number: 13-2199; Language: English; Chemical Name: Vinyl chloride--75-01-4; References: 85; Publication Type: Review; Journal Coden: JTEHD6; Human Indicator: Yes; Section Heading: Toxicity
N2 - The chemistry, biotransformation, toxicology, and carcinogenicity of vinyl chloride in animals and humans have been reviewed.
KW - Vinyl chloride--toxicity-;
KW - Toxicity--vinyl chloride--review, in animals and humans;
KW - Carcinogens--vinyl chloride--toxicity, review, in animals and humans;
KW - Metabolism--vinyl chloride--review, in animals and humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Modlin, J. F.;
AU - Brandling-Bennett, A. D.;
AU - Witte, J. J.;
AU - Campbell, C. C.;
AU - Meyers, J. D.;
T1 - Review of five years' experience with rubella vaccine in the United States
CT - Review of five years' experience with rubella vaccine in the United States
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 1975/01/01/
VL - 55
IS - Jan
SP - 20
EP - 29
SN - 00314005
AD - Immunization Div., Bureau of State Services, Center for Disease Control, Public Health Service, Dept. of H.E.W., Atlanta, Georgia 30333
N1 - Accession Number: 13-1036; Language: English; References: 48; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations; Sociology, Economics and Ethics; Abstract Author: Brenda Sue Martinez
N2 - After the licensing of live, attenuated rubella virus vaccine in 1969 and the immunization of 1 to 12 year old children, national morbidity figures showed a decline in reported rubella and congenital rubella syndrome. Rubella and congenital rubella syndrome each became a nationally notifiable disease to the Center for Disease Control in 1966. Recent rubella outbreaks have occurred in unimmunized high school and college students, and there appears to have been an upward shift in the age-specific incidence of rubella since the beginning of widespread immunization. Three live, attenuated rubella virus vaccines are licensed for use in the United States: the Cendehill strain grown in rabbit kidney cells, the HPV-77 strain prepared in duck embryo cell culture or in dog kidney cells. The latter has been voluntarily withdrawn from the market by the manufacturer because of its relatively high rate of adverse reactions. An intranasally administered vaccine, RA 27/3, prepared in human diploid cells is expected to be available soon and offers some advantages over the vaccines currently licensed.
KW - Rubella vaccines--immunization-;
KW - Immunization--rubella--review, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Clary, J. J.;
T1 - Nickel chloride-induced metabolic changes in the rat and guinea pig
CT - Nickel chloride-induced metabolic changes in the rat and guinea pig
JO - Toxicol. Appl. Pharmacol.
JF - Toxicol. Appl. Pharmacol.
Y1 - 1975/01/01/
VL - 31
IS - Jan
SP - 55
EP - 65
AD - Toxicology Branch, National Institute for Occupational Safety and Health, Public Health Service, D.H.E.W., Cincinnati, Ohio 45202
N1 - Accession Number: 12-4852; Language: English; Chemical Name: Nickel chloride--37211-05-5; References: 26; Journal Coden: TXAPA9; Section Heading: Toxicity
N2 - To explore the toxic effects of nickel chloride (I) on body metabolism and to elucidate the mechanism of action involved, I was given IP, 8 mg/kg, intratracheally, 1 mg, and by long term ingestion in drinking water, 225 ppm to rats and guinea pigs. In addition, an intragastric C 14 glucose load of 600 mg was also given to some intratracheally injected animals. A single IP or intratracheal injection of I in rats caused a rapid transient increase in serum glucose and a decrease in serum insulin and glycosuria. When exogenous insulin was given at the same time as the I challenge, the elevation of serum glucose was prevented. Glucose turnover studies indicated that the mechanism of action of I appears to be the inhibition of insulin release. This inhibition could be related to the extremely high concentration of nickel found in the pituitary, and its effect on the secretion of the pituitary hormones.
KW - Nickel chloride--toxicity-;
KW - Toxicity--nickel chloride--studies, mechanism of action, in guinea pigs and rats;
KW - Metabolism--nickel chloride--toxicity, studies, mechanism of action, in guinea pigs and rats;
KW - Mechanism of action--nickel chloride--toxicity, studies, in guinea pigs and rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Collins, T. F. X.;
AU - Keeler, H. V.;
AU - Black, T. N.;
AU - Ruggles, D. I.;
AU - Gray, G. C.;
T1 - Long-term effects of dietary amaranth in rats. Effects on reproduction
CT - Long-term effects of dietary amaranth in rats. Effects on reproduction
JO - Toxicology
JF - Toxicology
Y1 - 1975/01/01/
VL - 3
IS - Jan
SP - 115
EP - 128
AD - Div. of Toxicology and Div. of Mathematics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-3385; Language: English; Chemical Name: Amaranth--915-67-3; References: 16; Journal Coden: TXCYAC; Section Heading: Toxicity
N2 - Long-term, multigeneration effects of the dietary intake of the red dye amaranth were measured in a 3-generation reproduction and teratology study done on Osborne-Mendel rats. Dietary levels of 30, 300, 3000, or 30,000 ppm of the dye were ingested during the entire study. Amaranth ingestion did not affect fertility, average litter size, average number of liveborn animals, viability, or survival of offspring. Weanling weights were significantly decreased at the highest dose level in females in the fourth litter of the first generation, and in males and females in the first and third litters of the second generation. No cumulative effects of the dye were detected, nor was there an effect on any specific generation.
KW - Amaranth--toxicity-;
KW - Dyes--amaranth--toxicity, long-term dietary effects on reproduction, in rats;
KW - Teratogenicity--amaranth--effects, long-term dietary, in rats;
KW - Toxicity--amaranth--effects, long-term dietary, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Collins, T. F. X.;
AU - Black, T. N.;
AU - Ruggles, D. I.;
AU - Gray, G. C.;
T1 - Long-term effects of dietary amaranth in rats. 2. Effects on fetal development
CT - Long-term effects of dietary amaranth in rats. 2. Effects on fetal development
JO - Toxicology
JF - Toxicology
Y1 - 1975/01/01/
VL - 3
IS - Jan
SP - 129
EP - 140
AD - Div. of Toxicology and Div. of Mathematics, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-3386; Language: English; Chemical Name: Amaranth--915-67-3; References: 11; Journal Coden: TXCYAC; Section Heading: Toxicity
N2 - Long-term, multigeneration effects of the dietary intake of amaranth were measured in a 3-generation reproduction and teratology study done on Osborne-Mendel rats. Dietary levels of 30, 300, 3000, 30,000 ppm of the dye were ingested during the entire study. Progeny used to study developmental effects were obtained from matings of the first litters of the first generation (F1A) and of the second litters of the second generation (F2B) and were called F1A1 and F3B, respectively. In F1A, the number of corpora lutea was significantly lower at 30,000 ppm, and this expectedly affected the number of progeny, but the pre-implantation loss per litter did not differ from the control. Non-dose-related increases were seen in F1A resorptions and a non-dose-related decrease was seen in the mean fetal weight of the progeny. None of the implantation and fetal survival parameters analyzed for F2B were different from the control values. No specific skeletal or soft tissue abnormality could be correlated to dose level of the dye in either F1A1 or F3B.
KW - Amaranth--toxicity-;
KW - Teratogenicity--amaranth--effects, long-term dietary, on fetal development;
KW - Toxicity--amaranth--effects, long-term dietary, on fetal development;
KW - Dyes--amaranth--effects, long-term dietary, on fetal development, in rats;
KW - Placental transfer--amaranth--effects, fetal development, in rats;
KW - Metabolism--amaranth--placental transfer, effects, fetal development, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1976-26258-001
AN - 1976-26258-001
AU - Fedio, Paul
AU - Van Buren, John M.
T1 - Memory and perceptual deficits during electrical stimulation in the left and right thalamus and parietal subcortex.
JF - Brain and Language
JO - Brain and Language
JA - Brain Lang
Y1 - 1975/01//
VL - 2
IS - 1
SP - 78
EP - 100
CY - Netherlands
PB - Elsevier Science
SN - 0093-934X
N1 - Accession Number: 1976-26258-001. PMID: 1164669 Partial author list: First Author & Affiliation: Fedio, Paul; NIMH, Public Health Service, Bethesda, MD. Release Date: 19761001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Electrical Brain Stimulation; Parietal Lobe; Pattern Discrimination; Thalamotomy; Thalamus. Minor Descriptor: Recall (Learning); Recognition (Learning); Surgical Patients. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Electrophysiology (2530). Population: Human (10). Page Count: 23. Issue Publication Date: Jan, 1975.
AB - Mechanisms for perception and memory were probed by electrical stimulation via chronic electrodes in the thalamus of 40 18-65 yr old patients undergoing unilateral left or right thalamotomy. Stimulation within the left pulvinar nucleus induced transient dysphasia and a retrograde loss in recent memory for verbal memoranda. In contrast, comparable stimulation of the right pulvinar failed to disrupt verbal behavior and, instead, disabled the mechanism for discrimination and recognition of complex visual patterns. Findings suggest that an asymmetry in the functional organization of linguistic and nonverbal processes appears to exist at the level of the lateral thalamus. The hypothesis is advanced that the pulvinar scans incoming sensory traces and searches long-term memory registers for appropriate cues and labels. (36 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - left vs right thalamus vs parietal vs pulvinar electrical stimulation
KW - discrimination & recognition of complex visual patterns & object naming & recall performance
KW - 18-65 yr old patients undergoing unilateral left or right thalamotomy
KW - 1975
KW - Electrical Brain Stimulation
KW - Parietal Lobe
KW - Pattern Discrimination
KW - Thalamotomy
KW - Thalamus
KW - Recall (Learning)
KW - Recognition (Learning)
KW - Surgical Patients
KW - 1975
DO - 10.1016/S0093-934X(75)80056-3
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - ALLEVA, FREDERIC R.
AU - BARTTER, FREDERIC C.
T1 - Thioctic Acid and Mushroom Poisoning.
JO - Science
JF - Science
Y1 - 1975/01/24/
VL - 187
IS - 4173
M3 - Article
SP - 216
EP - 216
SN - 00368075
N1 - Accession Number: 85118401; ALLEVA, FREDERIC R. 1; BARTTER, FREDERIC C. 2; Affiliations: 1: Bureau of Drugs, Food and Drug Administration, Washington, D.C. 20204; 2: National Heart and Lung Institute, Bethesda, Maryland 20014; Issue Info: 1/24/1975, Vol. 187 Issue 4173, p216; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Johnson, R. E.;
AU - Tuchler, R. J.;
T1 - Role of the pharmacist in primary health care
CT - Role of the pharmacist in primary health care
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1975/02/01/
VL - 32
IS - Feb
SP - 162
EP - 164
SN - 00029289
AD - Public Health Service Indian Hospital, Crownpoint, New Mexico) (Reprints: U.S. Public Health Service, NIDA Addiction Research Center, Lexington, Kentucky
N1 - Accession Number: 12-1703; Language: English; References: 8; Journal Coden: AJHPA9; Section Heading: Pharmacy Practice; Sociology, Economics and Ethics
N2 - The provision of primary health care to a rural American Indian population by a pharmacist is discussed. The training and responsibilities of the pharmacist are described. An evaluation of the care provided by the pharmacist to 393 patients is presented.
KW - Health care--pharmacists--role, rural American Indian population;
KW - Pharmacists--health care--role, rural American Indian population;
KW - Community service--health care--pharmacists, role, rural American Indian population;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-1703&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Markenson, J. A.
AU - Daniels, C. A.
AU - Notikins, A. L.
AU - Hoofnagle, J. H.
AU - Gerety, J.
AU - Barker, L. F.
T1 - THE INTERACTION OF RHEUMATOID FACTOR WITH HEPATITIS B SURFACE ANTIGEN-ANTIBODY COMPLEXES.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/02//
VL - 19
IS - 2
M3 - Article
SP - 209
EP - 217
SN - 00099104
AB - A solid phase radioimmunoassay was developed in which the hepatitis B surface antigen was adsorbed to the surface of plastic beads. When the antigen-coated beads were incubated with human !gG antibody against hepatitis B surface antigen, immune complexes were formed on the solid phase surface. 1gM rheumatoid factor was found to hind to the hepatitis B surface antigen-antibody complexes but not to the antigen or the lgG antibody alone. Since both hepatitis B surface antigen-antibody complexes and rheumatoid factor are commonly present in type B viral hepatitis, it is suggested that rheumatoid factor may play a rote in the pathogenesis of this viral disease in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOIMMUNOASSAY
KW - HEPATITIS B
KW - IMMUNE complexes
KW - IMMUNOGLOBULIN G
KW - RHEUMATOID arthritis
KW - VIRAL hepatitis
N1 - Accession Number: 15945465; Markenson, J. A. 1; Daniels, C. A. 2; Notikins, A. L. 3; Hoofnagle, J. H. 4; Gerety, J. 4; Barker, L. F. 4; Source Information: Feb1975, Vol. 19 Issue 2, p209; Subject: RADIOIMMUNOASSAY; Subject: HEPATITIS B; Subject: IMMUNE complexes; Subject: IMMUNOGLOBULIN G; Subject: RHEUMATOID arthritis; Subject: VIRAL hepatitis; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Meyer, T.J.
AU - Azuma, I.
AU - Ribi, A.
T1 - Biologically Active Components from Mycobacterial Cell Walls.
JO - Immunology
JF - Immunology
Y1 - 1975/02//
VL - 28
IS - 2
M3 - Article
SP - 219
EP - 229
SN - 00192805
AB - The efficacy of various fractions of mycobacterial cell walls in producing experimental allergic encephalomyelitis (EAE) has been evaluated. BCG (Bacillus- Calmette-Guérin) cell walls were effective in producing EAE in all animals at dose levels as low as 40 μg. Study of subfractions of these cell walls revealed the following: (1) wax D was active, but required larger doses than BCG cell walls; (2) the chloroform-methanol-soluble (CMS) portion of wax D and P3 (a mycolic acid-trehalose ester contained therein) were inactive; (3) the chloroform-methanol- insoluble (CMI) portion of wax D was active; (4) exhaustively delipidated cell wall skeletons of BCG, Nocardia asteroides, Mycobacterium smegmatis, Corynebacterium diphtheriae and M. konsasii were active; (5) two water-soluble adjuvants prepared from mycobacteria were active. These results suggest that the mycobacterial structure responsible for EAE adjuvanticity is present in the organic solvent-insoluble cell wall skeleton framework. The activity of wax D may be due to the presence of cell-wall skeleton constituents which are found in varying quantity in most wax D preparations. Wax D components soluble in a solution of chloroforrn:methanol (diluted 2:1 v/v) do not produce EAE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGIC encephalomyelitis
KW - MYCOBACTERIA
KW - BACTERIAL cell walls
KW - BCG vaccination
KW - AUTOIMMUNE diseases
KW - GUINEA pigs
KW - IMMUNIZATION
N1 - Accession Number: 13370882; Meyer, T.J. 1; Azuma, I. 1; Ribi, A. 1; Source Information: Feb75, Vol. 28 Issue 2, p219; Subject: ALLERGIC encephalomyelitis; Subject: MYCOBACTERIA; Subject: BACTERIAL cell walls; Subject: BCG vaccination; Subject: AUTOIMMUNE diseases; Subject: GUINEA pigs; Subject: IMMUNIZATION; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Biehl, E. R.;
AU - Kenner, C. T.;
AU - Luttrell, G. H.;
AU - Middleton, D. L.;
T1 - Reduction of blue tetrazolium by corticosteroids
CT - Reduction of blue tetrazolium by corticosteroids
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/02/01/
VL - 64
IS - Feb
SP - 226
EP - 230
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 13-0181; Language: English; Chemical Name: Blue tetrazolium--1871-22-3; References: 22; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Abstract Author: D. R. Tousignaut
N2 - The mechanism of blue tetrazolium reduction by corticosteroids, the basis of the colorimetric analysis of steroids, is presented. The difference in the reaction rates of several corticosteroids is related to their differences in structure.
KW - Blue tetrazolium--reduction-;
KW - Steroids, cortico---colorimetry--blue tetrazolium, mechanism, based on steroid structure;
KW - Colorimetry--steroids, cortico---blue tetrazolium, mechanism, based on steroid structure;
KW - Structure--steroids, cortico---effects, reduction of blue tetrazolium, mechanism for colorimetric analysis of steroids;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Wilson, C. H.;
T1 - Identification of preservatives in cosmetic products by thin layer chromatography
CT - Identification of preservatives in cosmetic products by thin layer chromatography
JO - Journal of the Society of Cosmetic Chemists (England)
JF - Journal of the Society of Cosmetic Chemists (England)
Y1 - 1975/02/01/
VL - 26
IS - Feb
SP - 75
EP - 81
SN - 00379832
AD - Div. of Cosmetics Technology Food and Drug Administration 200 C Street, S.W. Washington, D.C. 20204
N1 - Accession Number: 12-3268; Language: English; References: 8; Journal Coden: JSCCA5; Section Heading: Drug Analysis
N2 - A rapid, sensitive method for the identification of preservatives in cosmetics consists of extracting the cosmetic with alcohol and developing an aliquot of the extract on a thin layer chromatography plate of silica gel GF 254. The preservatives are visualized on the plate by short wavelength UV light, iodine vapor, and/or several indicator sprays, and identified by comparison of Rf values with known standards. Twenty-five preservatives were characterized by this method. The preservatives in 9 commercial cosmetic products were also identified. The limit of detectability is approximately 0.1-0.5 mcg on the TLC plate, using a benzene-acetone solvent system.
KW - Preservatives--cosmetics--chromatography, thin layer, identification;
KW - Chromatography, thin layer--cosmetics--preservatives, identification;
KW - Cosmetics--preservatives--chromatography, thin layer, identification;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3268&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1975-20927-001
AN - 1975-20927-001
AU - Greene, Mark H.
AU - Brown, Barry S.
AU - DuPont, Robert L.
T1 - Controlling the abuse of illicit methadone in Washington, DC.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 1975/02//
VL - 32
IS - 2
SP - 221
EP - 226
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
N1 - Accession Number: 1975-20927-001. PMID: 1115569 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Greene, Mark H.; US Public Health Service, Bureau of Epidemiology, Atlanta, GA. Release Date: 19750701. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Laws; Drug Rehabilitation; Methadone. Classification: Forensic Psychology & Legal Issues (4200); Psychological & Physical Disorders (3200). Population: Human (10). Location: US. Page Count: 6. Issue Publication Date: Feb, 1975.
AB - The abuse of illicit methadone, outside the therapeutic setting, has aroused considerable controversy, particularly with regard to the public health hazards of primary methadone addiction, overdose, abuse, and childhood poisoning. The nature and extent of these negative aspects of the diversion of methadone into the illicit drug market was documented, using data collected between 1969 and 1974 in the District of Columbia. Data illustrate the severe problems created by the widespread availability of illicit methadone and suggest that, with appropriate controls, the large-scale use of methadone in addiction treatment is feasible with minimum risk of methadone addiction and overdose in the community. (17 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - availability & control & abuse of illicit methadone outside therapeutic setting
KW - Washington DC
KW - 1975
KW - Drug Abuse
KW - Drug Laws
KW - Drug Rehabilitation
KW - Methadone
KW - 1975
DO - 10.1001/archpsyc.1975.01760200085008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1975-20927-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Hirschhorn, N.;
AU - Woodward, W. E.;
AU - Evans, L. K.;
AU - Chickadonz, G. H.;
AU - Gordon, R. S.;
AU - \ET/;
T1 - Attempt prevention of diarrheal disease in Apache children with a nonabsorbable broad spectrum antimicrobial
CT - Attempt prevention of diarrheal disease in Apache children with a nonabsorbable broad spectrum antimicrobial
JO - Am. J. Trop. Med. Hyg.
JF - Am. J. Trop. Med. Hyg.
Y1 - 1975/03/01/
VL - 24
IS - Mar
SP - 320
EP - 325
AD - Reprints: Management Science for Health, One Broadway, Cambridge, Massachussetts 02142
AD - Whiteriver Indian Hospital, Indian Health Service, Whiteriver, Arizona
N1 - Accession Number: 13-3444; Language: English; Chemical Name: Colistin--1066-17-7; References: 27; Journal Coden: AJTHAB; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Justina E. Ogbuokiri
N2 - Prevention of diarrheal disease using colistin (I) was studied in a double blind procedure involving 176 children, 1-42 months of age, 81 of whom received I and 95 the placebo. I oral suspensions were given in a single dose of 5 mg/kg/day, monday through friday, for 13 weeks. Only 33% of the children were entirely free of diarrhea during this period. I had no significant effect on the number of episodes of diarrhea or hospitalizations for diarrhea; and it did not reduce the number of episodes of diarrhea. The group of children under 7 months of age assigned to the I regimen had significantly more days with diarrhea while those 7 to 30 months of age taking I had significantly fewer days of diarrhea. No effect was discerned in the children 31 to 42 months of age who had the lowest overall rate of attack.
KW - Colistin--diarrhea-;
KW - Suspensions--colistin--diarrhea, effects, in children;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3444&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zahn, T. P.;
AU - Abate, F.;
AU - Little, B. C.;
AU - Wender, P. H.;
T1 - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
CT - Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity
JO - Arch. Gen. Psychiatry
JF - Arch. Gen. Psychiatry
Y1 - 1975/03/01/
VL - 32
IS - Mar
SP - 381
EP - 387
AD - National Institutes of Health, Bldg 10, Rm 2N-262, Bethesda, Maryland 20014
AD - Unit on Psychophysiology, National Institute of Mental Health, Public Health Service, Dept. of H. E. W. Bethesda, Maryland
N1 - Accession Number: 13-1114; Language: English; Trade Name: Ritalin; Generic Name: Methylphenidate; Chemical Name: Methylphenidate--113-45-1 Dextroamphetamine--51-64-9; Therapeutic Class: (28:20); AHFS Class: Central nervous system stimulants methylphenidate (28:20); AHFS Class: Central nervous system stimulants dextroamphetamine; References: 26; Journal Coden: ARGPAQ; Human Indicator: Yes; Section Heading: Pharmacology; Abstract Author: Ronald E. Nagata, Jr.
N2 - Minimally brain dysfunctioned children on methylphenidate HC1 (Ritalin) or dextroamphetamine sulfate had increased skin conductance and heart rate and decreased skin temperatiure and reaction time when compared to baseline values obtained from normal and minimally brain dysfunctioned children not taking drugs. In the study of 54 normal and 42 minimally brain dysfunctioned children, autonomic base levels and responsivity to stimuli were investigated. The minimally brain dysfunctioned children were less reactive, autonomically, to all types of stimuli.
KW - Methylphenidate--effects-;
KW - Dextroamphetamine--effects-;
KW - Hyperkinesis--methylphenidate--effects, autonomic, in children;
KW - Hyperkinesis--dextroamphetamine--effects, autonomic, in children;
KW - Central nervous system stimulants--methylphenidate--effects, autonomic, in minimal brain dysfunction children;
KW - Central nervous system stimulants--dextroamphetamine--effects, autonomic, in minimal brain dysfunction children;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1114&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Morris, L. A.;
AU - O'Neal, E. C.;
T1 - Judgments about a drug's effectiveness: the role of expectations and outcomes
CT - Judgments about a drug's effectiveness: the role of expectations and outcomes
JO - Drugs Health Care
JF - Drugs Health Care
Y1 - 1975/03/01/
VL - 2
IS - Mar
SP - 179
EP - 186
AD - Food and Drug Administration (HFD-216), Rockville, Maryland 20852
N1 - Accession Number: 13-4442; Language: English; References: 14; Journal Coden: DRHCAP; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Information Processing and LiteratureDrug Evaluations
N2 - Two experiments analyzed how various expectations and feedback about a drug's effects were combined by the drug taker when judging the effectiveness of an ingested drug. Expectations were manipulated by varying instructions about the drug's effects. Outcomes were varied by the use of bogus behavioral and physiological feedback. The results indicate that only one clearcut expected drug effect is required to convince an individual that he has taken an effective drug. Unexpected effects can also convince an individual that the drug is working; however, the unexpected reaction must be attributed to the drug rather than to some other cause. These results are interpreted in terms of their implications regarding instructions patients receive about drugs. When drugs are administered, patients should be informed of clearcut behavioral or physiological drug effects. In this way, an individual is more likely to attribute reactions to the drug and assume that he has taken an effective medication. Problems regarding the generalization of these studies' results to a clinical population are discussed.
KW - Sociology--patients--drugs, clinical effectiveness, role of expectations and outcomes;
KW - Drugs, clinical effectiveness--sociology--patients, evaluation of drug efficacy, role of expectations and outcomes;
KW - Drug information--patients--effects, patient evaluation of drug efficacy, role of expectations and outcomes;
KW - Patient information--sociology--effects, patient evaluation of drug efficacy, role of expectations and outcomes;
KW - Methodology--drugs, clinical effectiveness--sociology, patients evaluation of drug efficacy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-4442&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
AU - Proctor, J. B.;
T1 - Determination of potassium guaiacolsulfonate by ion-pairing partition chromatography
CT - Determination of potassium guaiacolsulfonate by ion-pairing partition chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/03/01/
VL - 58
IS - Mar
SP - 276
EP - 277
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D. C. 20204
N1 - Accession Number: 12-3794; Language: English; Trade Name: Hydroxymethoxybenzenesulfonate; Generic Name: Guaiacolsulfonate; Therapeutic Class: (48:00); AHFS Class: Expectorants and cough preparations guaiacolsulfonate; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Potassium guaiacolsulfonate (potassium hydroxymethoxybenzenesulfonate) was extracted from cough mixtures in the form of its ion-pair with trihexylamine. The ion pair is readily eluted by chloroform from a pH 4.5 Celite column. The sulfonic acid is then back-extracted into aqueous alkali and determined spectrophotometrically. Assay of standard solutions by this procedure averaged 100.44%. The method was applied successfully to 4 commercial cough preparations containing a variety of other drugs.
KW - Guaiacolsulfonate--chromatography, column-;
KW - Expectorants and cough preparations--guaiacolsulfonate--chromatography, column, ion pair extraction;
KW - Ion pairs--guaiacolsulfonate--extraction, and column chromatography, cough preparations;
KW - Chromatography, column--guaiacolsulfonate--extraction, ion pair, cough mixtures;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-3794&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Verhulst, H. L.;
AU - Peterson, W.;
AU - Trissel, L.;
T1 - How to treat overdosages of drugs and common poisons
CT - How to treat overdosages of drugs and common poisons
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1975/03/01/
VL - 41
IS - Mar
SP - 46
EP - 51
SN - 00030627
AD - Bureau of Drugs, Food and Drug Administration, Bethesda, Maryland
N1 - Accession Number: 12-5481; Language: English; Journal Coden: PYTMAO; Human Indicator: Yes; Section Heading: Toxicity; Drug Evaluations; Abstract Author: Walter F. Stanaszek
N2 - Treatment for drug overdosage and common poisons, including general first aid procedures that can be performed by the lay public is discussed. Tables listing some of the more frequently ingested categories of substances as reported by poison control centers, a brief description of expected symptoms, and recommended treatment are included.
KW - Poisoning--therapy--and symptoms, for overdose and common poisons, discussion;
KW - Toxicity--drugs--poisons, and overdose, symptoms and therapy, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5481&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Corwin, E.;
T1 - Opening the closed door
CT - Opening the closed door
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1975/04/01/
VL - 9
IS - Apr
SP - 24
EP - 27
SN - 03621332
AD - U.S. Food and Drug Administration, Office of Public Affairs, Washington, D. C.
N1 - Accession Number: 12-6308; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: Henri R. Manasse, Jr.
N2 - Final FDA regulations, in response to the Freedom of Information Act requiring Federal agencies to make full public disclosure of nonconfidential information in government files, are discussed.
KW - Food and Drug Administration (U.S.)--regulations--Freedom of Information Act, discussion;
KW - Regulations--Food and Drug Administration--Freedom of Information Act, discussion;
KW - Information--Food and Drug Administration--regulations, Freedom of Information Act, discussion;
KW - Freedom of Information Act--Food and Drug Administration--regulations, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-6308&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fishman, S.;
T1 - Determination of estrogens in dosage forms by fluorescence using dansyl chloride
CT - Determination of estrogens in dosage forms by fluorescence using dansyl chloride
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/04/01/
VL - 64
IS - Apr
SP - 674
EP - 680
SN - 00223549
AD - Food and Drug Administration, Dept. of Health, Education, and Welfare, 850 Third Ave., Brooklyn, New York 11232
N1 - Accession Number: 13-1153; Language: English; Chemical Name: Estrone--53-16-7 Estradiol--50-28-2 Ethinyl estradiol--57-63-6; References: 39; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Estradiol derivatives in oil vehicles, aqueous suspensions of estrone and ethinyl estradiol tablets from commercial sources were analyzed by a fluorometric procedure. Analysis of the estrogens follows reaction with dansyl chloride. The recovery of estrogens from spiked samples indicated that the method is efficient and reproducible with average results within compendial limits.
KW - Estrone--fluorometry-;
KW - Estradiol--derivatives-;
KW - Ethinyl estradiol--fluorometry-;
KW - Fluorometry--estrogens--tablets, oil and aqueous solutions;
KW - Estrogens--fluorometry--tablets, oil and aqueous solutions;
KW - Tablets--ethinyl estradiol--fluorometry;
KW - Suspensions--estrone--fluorometry, aqueous;
KW - Oils--estradiol--derivatives, fluorometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1153&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cabana, B. F.;
T1 - Bioavailability and bioequivalency standards
CT - Bioavailability and bioequivalency standards
JO - Wis. Pharm. Ext. Bull.
JF - Wis. Pharm. Ext. Bull.
Y1 - 1975/04/01/
VL - 18
IS - Apr
AD - Office of Scientific Coordination, Bureau of Drugs, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 12-6156; Language: English; Section Heading: Biopharmaceutics
N2 - Recent bioavailability issues confronting the Food and Drug Administration are discussed. Ramification of various proposals to handle bioavailability problems and existing standards or specifications are discussed. Seven proposed definitions of bioavailability terms are presented.
KW - Drugs, availability--standards--proposals, FDA;
KW - Food and Drug Administration (U.S.)--standards--availability, proposals;
KW - Standards--availability--proposals, FDA;
KW - Nomenclature--availability--definitions, proposals;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-6156&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Eiermann, H. J.;
T1 - Scientific efforts of FDA's cosmetic program
CT - Scientific efforts of FDA's cosmetic program
JO - Cosmet. Perfum.
JF - Cosmet. Perfum.
Y1 - 1975/05/01/
VL - 90
IS - May
SP - 31
EP - 34
AD - Div. of Cosmetics Technology, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 13-0224; Language: English; Language of Summary: fr; ger; sp; Journal Coden: CSPEAX; Section Heading: Methodology; Abstract Author: Douglas L. Thompson
N2 - The role of the Division of Cosmetics of the FDA is briefly outlined. The development of analytical methods and programs for testing the toxicity of cosmetic products are discussed.
KW - Food and Drug Administration (U.S.)--cosmetics--research, programs, description;
KW - Cosmetics--toxicity--programs, FDA;
KW - Research--cosmetics--programs, FDA;
KW - Toxicity--cosmetics--research, FDA programs;
KW - Methodology--toxicity--cosmetics, FDA research programs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-0224&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ruskin, A.;
T1 - Quality control of drug information transfer
CT - Quality control of drug information transfer
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 89
EP - 90
SN - 00928615
AD - Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20204
N1 - Accession Number: 13-6016; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Pharmacy PracticeSociology, Economics and Ethics; Abstract Author: James A. Starner
N2 - The problem of developing and supplying providers and users of drugs with accurate information, so that responsible decisions may be made about choice and use of medications is discussed. The need for ethical advertising and promotion by the pharmaceutical industry is stressed.
KW - Advertising--drugs--ethical, need for accurate information;
KW - Industry, pharmaceutical--advertising--ethical, need for accurate information;
KW - Drug information--ethics--advertising, need for accurate information;
KW - Ethics--drug information--advertising, need for accurate information;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6016&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Barry, E.;
T1 - Latin American periodicals as a source of drug information
CT - Latin American periodicals as a source of drug information
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 120
EP - 122
SN - 00928615
AD - Neuropharmacological Drug Products Div., Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20204
N1 - Accession Number: 13-5378; Language: English; References: 2; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The problems of identifying and locating Latin American periodicals which may be sources of drug information are discussed. Several publications which can serve as guides to the literature of Latin American pharmacy and pharmacology are listed.
KW - Literature--Latin America--need, identification of drug information sources;
KW - Latin America--literature--need, identification of drug information sources;
KW - Drug information--Latin America--literature, need for identifying sources;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5378&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Armstrong, G.;
T1 - Newer aspects of national poison control information system with emphasis on drugs
CT - Newer aspects of national poison control information system with emphasis on drugs
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 168
EP - 170
SN - 00928615
AD - Poison Control Program, Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20204
N1 - Accession Number: 13-5699; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - The significance of computerized, remote terminal information retrieval to the activities of the National Clearinghouse for Poison Control Centers and its associated regional centers is discussed. The use of computerized data files allows greater ease in updating poison control information, the inclusion of more types of data that may be of assistance to the requestor, and more extensive cross indexing of generic and trade names for a given product. A subprogram of the system allows the entered name to be matched phonetically with others in the file and thus can compensate for errors in spelling or not knowing the correct spelling of the product name.
KW - National Clearinghouse for Poison Control Centers--computers--drug information, usage, discussion;
KW - Automation, data processing, computers--National Clearinghouse for Poison Control Centers--drug information, usage, discussion;
KW - Drug information--National Clearinghouse for Poison Control Centers--computers, usage, discussion;
KW - Poisoning--drug information--computers, usage, National Clearinghouse for Poison Control Centers;
KW - Toxicity--drug information--poisoning, computer usage, National Clearinghouse for Poison Control Centers;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5699&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Slavin, M.;
T1 - Food and Drug Administration drug registration and listing system
CT - Food and Drug Administration drug registration and listing system
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1975/05/01/
VL - 9
IS - May-Sep
SP - 239
EP - 240
SN - 00928615
AD - Div. of Data Management, Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20204
N1 - Accession Number: 13-6599; Language: English; Journal Coden: DGIJB9; Section Heading: Legislation, Laws and Regulations; Information Processing and Literature; Abstract Author: James A. Starner
N2 - A summarization of the implementation and associated problems of the Drug Listing Act of 1972 (registration of drug manfacturers and listing of all drugs in distribution, each drug to have a National Drug Code (NDC) number) are presented.
KW - Drug Listing Act of 1972--implementation--and problems, discussion;
KW - Laws--Drug Listing Act of 1972--implementation, and problems, discussion;
KW - National Drug Code--Drug Listing Act of 1972--implementation, and problems, discussion;
KW - Codes--National Drug Code--Drug Listing Act of 1972, implementation and problems, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6599&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cunnigham, C. G.;
AU - Barken, S.;
T1 - Column chromatographic analysis of barbiturates in their dosage forms. 2. Secobarbital, amobarbital, and pentobarbital
CT - Column chromatographic analysis of barbiturates in their dosage forms. 2. Secobarbital, amobarbital, and pentobarbital
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/05/01/
VL - 58
IS - May
SP - 525
EP - 527
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 12-5635; Language: English; Chemical Name: Pentobarbital--76-74-4 Secobarbital--76-73-3 Amobarbital--57-43-2; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A general method for the analysis of barbiturates, using column partition chromatography, was extended to the assay of secobarbital, amobarbital, and pentobarbital. A solution of the barbiturate constitutes the immobile phase in the chromatographic system. It is eluted with ether-isooctane (1:9) and passed onto a tribasic potassium phosphate column, which retains the barbiturate while extraneous materials are washed out. The barbiturate is removed from the column with ether-isooctane (3:1), extracted from the eluate with ammonia, and measured spectrophotometrically.
KW - Pentobarbital--chromatography, column-;
KW - Secobarbital--chromatography, column-;
KW - Amobarbital--chromatography, column-;
KW - Chromatography, column--secobarbital--dosage forms;
KW - Chromatography, column--amobarbital--dosage forms;
KW - Dosage forms--barbiturates--chromatography, column;
KW - Barbiturates--chromatography, column--dosage forms;
KW - Chromatography, column--pentobarbital--dosage forms;
KW - Sedatives and hypnotics--barbiturates--chromatography, column, dosage forms;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5635&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheinin, E. B.;
AU - Benson, W. R.;
AU - Brannon, W. L.;
AU - Schwartzman, G.;
T1 - Analysis of pharmaceuticals by combined gas chromatography-mass spectrometry. 1. Analysis of a medicated aerosol spray
CT - Analysis of pharmaceuticals by combined gas chromatography-mass spectrometry. 1. Analysis of a medicated aerosol spray
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/05/01/
VL - 58
IS - May
SP - 530
EP - 540
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 12-5922; Language: English; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A medicated aerosol product was qualitatively analyzed by combined gas chromatography-mass spectrometry. The data were processed by a minicomputer. Ten of the 11 peaks in the gas chromatogram were identified with assistance of the NIH Chemical Information System mass spectral search system. The unidentified peak is probably a member of the terpene class. The aerosol propellants were also partially analyzed by IR spectrophotometry.
KW - Aerosols--chromatography, gas--and mass spectrometry;
KW - Chromatography, gas--aerosols--and mass spectrometry;
KW - Spectrometry, mass--aerosols--and GLC;
KW - Propellants--chromatography, gas--and mass spectrometry, medicated aerosols;
KW - Terpenes--aerosols--analysis, GC-MS;
KW - Spectrometry, infrared--propellants--and GLC, medicated aerosols;
KW - Propellants--spectrometry, infrared--and GLC, medicated aerosols;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5922&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bailey, J. E.;
AU - Cox, E. A.;
T1 - Chromatographic analysis of 4,4\PR/-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6
CT - Chromatographic analysis of 4,4\PR/-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/05/01/
VL - 58
IS - May
SP - 609
EP - 613
AD - Div. of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 12-5923; Language: English; Chemical Name: FD&C Yellow No. 6--2783-94-0; References: 7; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - 4,4\PR/-(Diazoamino)-dibenzenesulfonic acid was identified in samples of FD&C Yellow No. 6 analyzed by high pressure liquid chromatography and chromatography.
KW - FD&C Yellow No. 6--contamination-;
KW - 4,4\PR/-(Diazoamino)-dibenzenesulfonic acid--contamination-;
KW - Chromatography, liquid--FD&C Yellow No. 6--high pressure, 4.4\PR/-(diazoamino)-dibenzenesulfonic acid impurity;
KW - Contamination--FD&C Yellow No. 6--detection, 4,4\PR/-(diazoamino)-dibenzenesulfonic acid, high pressure liquid chromatography;
KW - Dyes--FD&C Yellow No. 6--contamination, 4,4\PR/-(diazoamino)-dibenzenesulfonic acid, high pressure liquid chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5923&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Draper, R. E.;
T1 - Effect of FD&C Red No. 3 (erythrosine) on the determination of FD&C azo color additives
CT - Effect of FD&C Red No. 3 (erythrosine) on the determination of FD&C azo color additives
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/05/01/
VL - 58
IS - May
SP - 614
EP - 616
AD - Food and Drug Administration, 50 Fulton St., San Francisco, California 94102
N1 - Accession Number: 12-5636; Language: English; Trade Name: FD&C Red No. 3; Generic Name: Erythrosine sodium; Chemical Name: Erythrosine sodium--16423-68-0; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Erythrosine sodium has been shown to interact with FD&C Red No. 2, 4, and 40 and FD&C Yellow No. 5 and 6 and thus interfere in the determination of these azo color additives. This interaction is concentration dependent and occurs only in alkaline solution and in the presence of light. Precautions are detailed to minimize this interaction.
KW - Erythrosine sodium--analysis-;
KW - Analysis--dyes--FD&C, azo color additives, intereference with erythrosine;
KW - Dyes--erythrosine sodium--analysis, interference with analysis of FD&C azo color additives;
KW - Dyes--azo--analysis, interference by erythrosine;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5636&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Gonorrhea\M/recommended treatment schedules\M/1974
CT - Gonorrhea\M/recommended treatment schedules\M/1974
JO - Journal of Pediatrics (USA)
JF - Journal of Pediatrics (USA)
Y1 - 1975/05/01/
VL - 86
IS - May
SP - 794
EP - 797
SN - 00223476
AD - United States Public Health Service, Center for Disease Control, Atlanta, Georgia
N1 - Accession Number: 13-0767; Language: English; Journal Coden: JOPDAB; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations; Abstract Author: Ann Vengrofski
N2 - Treatment schedules for antibiotic therapy in complicated and uncomplicated gonorrhea are summarized. Treatment regimens for uncomplicated gonorrhea, associated with pregnancy, pelvic inflammatory disease, disseminated gonococcal infection, and pediatric patients are recommended.
KW - Gonorrhea--therapy--complicated, and uncomplicated, dosage schedules, in pregnancy and in pediatric patients;
KW - Dosage schedules--antibiotics--gonorrhea, complicated, and uncomplicated, therapy, in pregnancy and in pediatric patients;
KW - Antibiotics--dosage schedules--gonorrhea, complicated and uncomplicated, in pregnancy and in pediatric patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1976-01695-001
AN - 1976-01695-001
AU - Goldsmith, Francis J.
AU - Hochbaum, Godfrey M.
T1 - Changing people's behavior toward the environment.
JF - Health Services Reports
JO - Health Services Reports
JA - Health Serv Rep
Y1 - 1975/05//May-Jun, 1975
VL - 90
IS - 3
SP - 231
EP - 234
CY - US
PB - U. S. Public Health Service
SN - 0090-2918
N1 - Accession Number: 1976-01695-001. PMID: 807937 Other Journal Title: H.S.M.H.A. Health Reports; Public Health Reports. Partial author list: First Author & Affiliation: Goldsmith, Francis J.; Public Health Service, Health Services Administration, Rockville, MD. Other Publishers: Association of Schools of Public Health; Elsevier Science; Oxford University Press; U.S. Dept. of Health, Education, and Welfare, Health Services and Mental Health Administration; U.S. Marine Hospital Service. Release Date: 19760101. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Modification; Ecology; Environment. Classification: Environmental Issues & Attitudes (4070). Population: Human (10). Page Count: 4. Issue Publication Date: May-Jun, 1975.
AB - Argues that behavioral techniques should be developed to induce individuals to improve the environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral techniques
KW - environmental behavior
KW - 1975
KW - Behavior Modification
KW - Ecology
KW - Environment
KW - 1975
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1976-01695-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Daugharty, H.
AU - Gogel, R.
T1 - RESPONSE IN GUINEA-PIGS TO INOCULATION WITH MIXTURES OF HEPATITIS B ANTIGEN AND ANTIBODY AT VARIABLE RATIOS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/06//
VL - 20
IS - 3
M3 - Article
SP - 537
EP - 548
SN - 00099104
AB - Equivalence proportions of hepatitis B (HB) antigen (Ag) and antibody (Ab) positive plasmas were determined by liquid-phase radioimmunoassay (RIA). Variable proportions of HB Ab preincubated with HB Ag resulted in HB Ag:Ab ratios ranging from greater than to less than unity. Pairs of guinea-pigs were immunized intramuscularly with these mixtures and bled at approximately 3-week intervals. Sera were tested by RIA for presence of HB Ag and Ab. Animal, injected with a four-fold equivalence excess of HB Ab did not respond with Ab to HB Ag. Only at an equivalence ratio (1:1) for HB:Ag did one of two animals demonstrate a stable and consistent immune response. This began it the 11th week after inoculation. The earliest immune response detected in both guinea-pigs of a pair was when HB Ag was given at a four-fold equivalence excess over the Ab. This response was noted as early as 5 weeks. Quantitatively, the immune responses correlated very well with the HB Ag dose, i.e. higher Ag: Ab ratios resulted in greater anti-HB responses. Very low levels of antigenaemia were evidenced by test specimens inhibiting the precipitation of 125-labelled HB in RIA and these levels persisted for 4½ months. Ant igenaemia was noted only for those animals which received mixtures of lower ratios of Ag : Ab as inoculum. Excess Ab caused immunological suppression rather than the enhancement that might be expected to occur with Ag : Ah complexes alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B
KW - IMMUNE response
KW - IMMUNOLOGY
KW - RADIOIMMUNOASSAY
KW - BLOOD plasma
KW - LIVER diseases
N1 - Accession Number: 15951193; Daugharty, H. 1; Gogel, R. 1; Source Information: Jun1975, Vol. 20 Issue 3, p537; Subject: HEPATITIS B; Subject: IMMUNE response; Subject: IMMUNOLOGY; Subject: RADIOIMMUNOASSAY; Subject: BLOOD plasma; Subject: LIVER diseases; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Janssen, W. F.;
T1 - America's first food and drug laws
CT - America's first food and drug laws
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1975/06/01/
VL - 9
IS - Jun
SP - 12
EP - 19
SN - 03621332
AD - U.S. Dept. of HEW, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 13-0882; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations
N2 - A review of the promulgation of food and drug laws in the United States is presented Statutes dating from the mid-1600's attest to the colonists' concern about adulterated food and its impact on trade and their difficulty in attempting to regulate drugs.
KW - History--laws--United States, food and drug;
KW - United States--history--laws, food and drug;
KW - Laws--United States--history, food and drug;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-0882&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Kenner, C. T.;
AU - Biehl, E. R.;
T1 - Determination of iodochlorhydroxyquin and corticosteroids in pharmaceutical formulations
CT - Determination of iodochlorhydroxyquin and corticosteroids in pharmaceutical formulations
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/06/01/
VL - 64
IS - Jun
SP - 1013
EP - 1017
SN - 00223549
AD - Dallas District, Food and Drug Administration, Dallas, Texas 75204
N1 - Accession Number: 13-1464; Language: English; Therapeutic Class: (84:00); AHFS Class: Topical preparations iodochlorhydroxyquin, combination, steroids, cortico-; References: 20; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: D. R. Tousignaut
N2 - Topical formulations containing iodochlorhydroxyquin (I) and various corticosteroids (II) were analyzed for drug content. An acetonitrile-diatomaceous earth column was used to separate the I and II. I was determined by both a UV absorbance method and a new compleximetric method. II were determined by the blue tetrazolium and isoniazid procedures.
KW - Iodochlorhydroxyquin--combination, steroids, cortico--;
KW - Steroids, cortico---combination, iodochlorhydroxyquin--topical preparations, column chromatography separation and comparative analytic methods;
KW - Topical preparations--iodochlorhydroxyquin, combination, steroids, cortico---separation, column chromatography and comparison of analytic technique;
KW - Topical preparations--steroids, cortico-, combination, iodochlorhydoxyquin--separation, column chromatography and comparison of analytic technique;
KW - Chromatography, column--iodochlorhydroxyquin, combination, steroids, cortico---topical preparations, separation, and comparison of analytic techniques;
KW - Chromatography, column--steroids, cortico-, combination, iodochlorhydroxyquin--topical preparations, separation, and comparison of analytic techniques;
KW - Spectrometry, ultraviolet--iodochlorhydroxyquin--topical preparations, combined with corticosteroids;
KW - Complexometry--iodochlorhydroxyquin--topical preparations, combined with corticosteroids;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-1464&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hoffman, T. J.;
AU - Thompson, R. D.;
T1 - Determination of methadone hydrochloride in a maintenance dosage formulation
CT - Determination of methadone hydrochloride in a maintenance dosage formulation
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1975/07/01/
VL - 32
IS - Jul
SP - 711
EP - 712
SN - 00029289
AD - Pharmaceutical Analysis Section, U.S. Food and Drug Administration, Minneapolis, Minnesota 55401
N1 - Accession Number: 12-5335; Language: English; Chemical Name: Methadone--76-99-3; References: 9; Publication Type: Quality Control and Drug Analysis; Journal Coden: AJHPA9; Section Heading: Drug Analysis
N2 - A colorimetric method for the direct quantitative assay of methadone hydrochloride in liquid oral dosage forms is presented. The procedure involves the formation of a dye complex with bromothymol blue buffer solution. The resultant complex is extracted with benzene and measured spectrophotometrically. Duplicate tests on the formulation showed 99.2% of the labeled amount of methadone.
KW - Methadone--colorimetry-;
KW - Solutions--methadone--colorimetry;
KW - Colorimetry--methadone--solutions, oral;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=12-5335&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bell, S.;
T1 - Thin layer chromatographic separation and spectrodensitometric determination of higher and lower sulfonated subsidiary dyes in FD&C Yellow No. 6
CT - Thin layer chromatographic separation and spectrodensitometric determination of higher and lower sulfonated subsidiary dyes in FD&C Yellow No. 6
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/07/01/
VL - 58
IS - Jul
SP - 717
EP - 718
AD - Div. of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-0517; Language: English; Chemical Name: FD&C Yellow No. 6--2783-94-0; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - FD&C Yellow No. 6--chromatography, thin layer-;
KW - Chromatography, thin layer--FD&C Yellow No. 6--and spectrodensitometry, sulfonated subsidiary dye constituents;
KW - Densitometry--FD&C Yellow No. 6--and TLC, sulfonated subsidiary dye constituents;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-0517&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1976-05236-001
AN - 1976-05236-001
AU - Placek, Paul J.
T1 - Welfare workers as family planning change agents and the perennial problem of heterophily with welfare clients.
JF - Journal of Applied Behavioral Science
JO - Journal of Applied Behavioral Science
JA - J Appl Behav Sci
Y1 - 1975/07//Jul-Sep, 1975
VL - 11
IS - 3
SP - 298
EP - 316
CY - US
PB - Sage Publications
SN - 0021-8863
SN - 1552-6879
N1 - Accession Number: 1976-05236-001. Partial author list: First Author & Affiliation: Placek, Paul J.; US HEW, Public Health Service, National Ctr for Health Statistics, Rockville, MD. Release Date: 19760301. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Family Planning; Social Casework; Social Change; Social Workers; Welfare Services (Government). Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 19. Issue Publication Date: Jul-Sep, 1975.
AB - Uses 2 concepts from E. Rogers (1971), heterophily (i.e., the degree to which individuals who interact are different in certain attributes) and the role of change agents to explain problems which welfare workers have in being influential family planning change agents for welfare mothers. Interviews with 58 welfare workers and 300 welfare mothers reveal that heterophily characterizes the 2 groups in social and demographic characteristics, birth control attitudes, family size norms, and abortion attitudes and that heterophily may partially account for welfare workers' limited conformity to the change agent role in family planning counseling. (62 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - heterophily & role of change agents
KW - problems of welfare workers as family planning change agents in influencing welfare mothers
KW - 1975
KW - Family Planning
KW - Social Casework
KW - Social Change
KW - Social Workers
KW - Welfare Services (Government)
KW - 1975
DO - 10.1177/002188637501100304
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1976-05236-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Rauscher Jr., Frank J.
T1 - Research and the National Cancer Program.
JO - Science
JF - Science
Y1 - 1975/07/11/
VL - 189
IS - 4197
M3 - Article
SP - 115
EP - 119
SN - 00368075
N1 - Accession Number: 85136294; Rauscher Jr., Frank J. 1; Affiliations: 1: Director, National Cancer Program, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014; Issue Info: 7/11/1975, Vol. 189 Issue 4197, p115; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Freeman, R. B.;
AU - Smith, W. M.;
AU - Richardson, J. A.;
AU - Hennelly, P. J.;
AU - Thurm, R. H.;
AU - \ET/;
T1 - Long-term therapy for chronic bacteriuria in men
CT - Long-term therapy for chronic bacteriuria in men
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1975/08/01/
VL - 83
IS - Aug
SP - 133
EP - 147
SN - 00034819
AD - Reprints: Public Health Service Hospital, 15th Ave. and Lake St., San Francisco, California 94118
AD - Div. of Hospitals and Clinics, Bureau of Medical Services, U.S. Public Health Service, and Univ. of Rochester Medical Center, Rochester, New York 14642
N1 - Accession Number: 13-2853; Language: English; Chemical Name: Sulfamethizole--144-82-1 Nitrofurantoin--67-20-9 Methenamine--100-97-0; References: 100; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Response to therapy with sulfamethizole, nitrofurantoin and methenamine; renal function; and mortality were analyzed in a prospective study of 249 men with bacteriuria followed for up to 10 years. All patients received initial organism-specific therapy followed by 2 years of continuous treatment, which delayed recurrence of bacteriuria and reduced acute clinical exacerbations of infection. Patients with pure \IT/Escherichia coli\OK/ bacteriuria, normal IV pyelogram, no previous therapy, and a normal prostate had a good prognosis with short term therapy alone. The presence of prostatis or upper urinary tract calculi, pyelonephritic scars, or mixed or enterococcal infections predicted a poor bacteriologic prognosis. In the absence of severe urologic disease or concomitant noninfectious renal disease no patients with persistent bacteriuria developed renal failure. Continuous therapy is of value in selected male patients with bacteriuria in reducing recurrence and acute clinical exacerbations of urinary tract infection.
KW - Sulfamethizole--bacteriuria-;
KW - Nitrofurantoin--bacteriuria-;
KW - Methenamine--bacteriuria-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Angelotti, R.;
T1 - Flavors: the future and FDA
CT - Flavors: the future and FDA
JO - Cosmet. Perfum.
JF - Cosmet. Perfum.
Y1 - 1975/08/01/
VL - 90
IS - Aug
SP - 43
EP - 48
AD - Bureau of Foods, Food and Drug Administration, Washington, D. C.
N1 - Accession Number: 13-0560; Language: English; Journal Coden: CSPEAX; Section Heading: Legislation, Laws and Regulations
N2 - The January 19, 1973 labeling regulations, in particular, Sec. 1.12 on ""Food Labeling: spices, flavoring, colorings and chemical preservatives'' is discussed and explained as it relates to the flavor industry. The FDA looks to the flavor industry itself for continued aid, cooperation, in compliance by self-helping and self-regulating.
KW - Flavors--regulations--labeling, discussion;
KW - Labeling--flavors--regulations, discussion;
KW - Food and Drug Administration (U.S.)--flavors--regulations, labeling, discussion;
KW - Regulations--flavors--labeling, FDA, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-0560&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, J. H.;
T1 - Analysis of individual thyroid tablets
CT - Analysis of individual thyroid tablets
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/08/01/
VL - 64
IS - Aug
SP - 1393
EP - 1396
SN - 00223549
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-3278; Language: English; Chemical Name: Thyroid--8028-36-2; References: 5; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - A procedure was developed for the assay of individual thyroid tablets or composite samples equivalent to as little as 0.033 g of thyroid. The sample is ignited in a closed atmosphere of oxygen and, after a series of redox reactions, the iodine is determined spectrophotometrically at 340-460 nm as the triiodide ion. The results agree well with those obtained by the USP thyroid tablet assay.
KW - Thyroid--colorimetry-;
KW - Tablets--thyroid--colorimetry;
KW - Colorimetry--thyroid--tablets;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3278&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brannon, W. L.;
AU - Levine, J.;
T1 - Infrared identification test for scopolamine as the hydrobromide
CT - Infrared identification test for scopolamine as the hydrobromide
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/09/01/
VL - 58
IS - Sep
SP - 871
EP - 874
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-2930; Language: English; Chemical Name: Scopolamine--51-34-3; References: 4; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method for preparing scopolamine hydrobromide (I) samples which will give reproducible IR spectra is described. A column chromatographic procedure is used to both isolate the drug from tablets and injections and form the hydrobromide salt. This yields reproducible IR spectra and thus constitutes an identity test for I.
KW - Scopolamine--hydrobromide-;
KW - Spectrometry, infrared--scopolamine--hydrobromide, column chromatography, identification, in tablets and injections;
KW - Chromatography, column--scopolamine--hydrobromide, IR spectrometry, identification, in tablets and injections;
KW - Tablets--scopolamine--hydrobromide, IR spectrometry, column chromatography, identification;
KW - Injections--scopolamine--hydrobromide, IR spectrometry, column chromatography, identification;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-2930&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kirchhoefer, R. D.;
AU - Wells, C. E.;
T1 - Semiautomated analysis of ergonovine maleate or methylergonovine maleate tablets and injections by colorimetric or fluorometric systems
CT - Semiautomated analysis of ergonovine maleate or methylergonovine maleate tablets and injections by colorimetric or fluorometric systems
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/09/01/
VL - 58
IS - Sep
SP - 879
EP - 883
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 13-2367; Language: English; Chemical Name: Ergonovine--60-79-7 Methylergonovine--113-42-8; References: 16; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Two semiautomated continuous flow analytical systems were developed to determine ergonovine and methylergonovine maleate in single tablets and injections. The active ingredient is dissolved in a tartrate buffer. In the fluorometric method the stream is automatically diluted with tartrate buffer and excited with UV light; the resulting fluorescence is measured and recorded. In the nitrite colorimetric method, the stream is automatically made basic with sodium hydroxide and extracted with n-butanol. The extract is mixed with p-dimethylaminobenzaldehyde reagent. After reaction, the solution is mixed with sodium nitrite solution, and the developed color is measured at 550 nm. Recoveries of 100% were obtained from spiked placebos. Standard deviations for powdered tablet and injection samples ranged from 0.63 to 1.24%. Comparisons with the USP XVIII methods are presented.
KW - Ergonovine--maleate-;
KW - Methylergonovine--maleate-;
KW - Colorimetry--ergonovine--maleate, and fluorometry, tablets and injections;
KW - Colorimetry--methylergonovine--maleate, and fluorometry, tablets and injections;
KW - Fluorometry--ergonovine--maleate, and colorimetry, tablets and injections;
KW - Fluorometry--methylergonovine--maleate, and colorimetry, tablets and injections;
KW - Tablets--ergonovine--maleate, colorimetry, and fluorometry;
KW - Tablets--methylergonovine--maleate, colorimetry, and fluorometry;
KW - Injections--ergonovine--maleate, colorimetry, and fluorometry;
KW - Injections--methylergonovine--maleate, colorimetry and fluorometry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fritz, J. C.;
AU - Pla, G. W.;
AU - Harrison, B. N.;
AU - Clark, G. A.;
T1 - Estimation of the bioavailability of iron
CT - Estimation of the bioavailability of iron
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/09/01/
VL - 58
IS - Sep
SP - 902
EP - 905
AD - Div. of Nutrition, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-2305; Language: English; Chemical Name: Iron--7439-89-6; References: 10; Journal Coden: JANCA2; Section Heading: Biopharmaceutics
N2 - Eight laboratories conducted a hemoglobin repletion test for the estimation of the bioavailability of iron from 4 sources, using depleted male albino rats. Ferrous sulfate was used as the reference standard. Ferric orthophosphate was found to have a relative biological value of 11 (range 6-22), an old sample of hydrogen-reduced iron 27 (range 15-41), and ferric citrate 96 (range 75-125). Good results were obtained with a simplified basal diet prepared without ingredients that had previously contributed variable quantities of iron. There was no apparent advantage in using the change in hemoglobin during the repletion period instead of the final hemoglobin value as the criterion of response to iron supplements. Several statistical treatments of the data yielded similar conclusions regarding relative biological values of the iron sources.
KW - Iron--availability-;
KW - Drugs, availability--iron--methodology, hemoglobin repletion test, in rats;
KW - Methodology--iron--availability, hemoglobin repletion test, in rats;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheppard, E. P.;
AU - Wilson, C. H.;
T1 - Preservatives in cosmetics: partition chromatography and ultraviolet spectrophotometry
CT - Preservatives in cosmetics: partition chromatography and ultraviolet spectrophotometry
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1975/09/01/
VL - 58
IS - Sep
SP - 937
EP - 940
AD - Div. of Cosmetics Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-2931; Language: English; Chemical Name: Phenol--108-95-2 Hexachlorophene--70-30-4; Therapeutic Class: (38:00); AHFS Class: Disinfectants hexachlorophene; References: 5; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Separation by partition chromatography and determination by UV spectrophotometry have been applied to the analysis of 16 cosmetic preservatives. The method, adapted from the method for hexachlorophene, has broad applicability for the determination of preservatives in cosmetics. Phenols, parabens, biphenyls, carbinilides, and salicylanilides were analyzed. The partition chromatographic technique does not separate 3,4\PR/,5-tribromosalicylanilide (I) from hexachlorophene or Irgasan DP 300. However, the UV determination of these compounds was accomplished by utilizing an absorption maximum of I which does not coincide with that of the other 2 preservatives. Recoveries averaged 97% for all the compounds studied.
KW - Phenol--derivatives-;
KW - Hexachlorophene--chromatography, column-;
KW - Cosmetics--preservatives--chromatography, column, and UV spectrometry;
KW - Preservatives--cosmetics--chromatography, column, and UV spectrometry;
KW - Chromatography, column--preservatives--cosmetics, and UV spectrometry;
KW - Spectrometry, ultraviolet--preservatives--cosmetics, and column chromatography;
KW - Parabens--chromatography, column--and UV spectrometry, cosmetics;
KW - Disinfectants--hexachlorophene--chromatography, column, and UV spectrometry, cosmetics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Haley, T. J.;
T1 - Asbestosis: a reassessment of the overall problem
CT - Asbestosis: a reassessment of the overall problem
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/09/01/
VL - 64
IS - Sep
SP - 1435
EP - 1449
SN - 00223549
AD - National Center for Toxicological Research, Food and Drug Administration, Dept. of HEW, Jefferson, Arkansas 72079
N1 - Accession Number: 13-3310; Language: English; Chemical Name: Asbestos--1332-21-4; References: 246; Journal Coden: JPMSAE; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Paul R. Webster
N2 - A review of asbestosis concerning the chemistry of asbestos, industrial hygiene, animal and human toxicity, and carcinogenic aspects is presented. It was suggested that more attention be paid to analytical chemistry, particle size and epidemiology of asbestos. Difficulties encountered in the analysis of asbestos reside in the fact that chemical composition differs only slightly from one variety to another and contamination with other metallic ions is prevalent in asbestos production. Since particle size appears to be the controlling factor in the induction of asbestosis and cancer, accurate sizing must be done to prevent a negative result. Epidemiology should include a continuing follow up of known cases of asbestosis and the addition of new cases as they become apparent.
KW - Asbestos--toxicity-;
KW - Toxicity, environmental--asbestos--and analysis, review;
KW - Analysis--asbestos--and toxicity, review;
KW - Particle size--asbestos--effects, in asbestosis and cancer, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Doyle, T. D.;
AU - Stewart, J. M.;
AU - Filipescu, N.;
AU - Benson, W. R.;
T1 - Configuration of dienestrol
CT - Configuration of dienestrol
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/09/01/
VL - 64
IS - Sep
SP - 1525
EP - 1528
SN - 00223549
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-3528; Language: English; Chemical Name: Dienestrol--84-17-3; References: 11; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry
N2 - The configuration of dienestrol was resolved by a detailed spectrochemical investigation, including single crystal x-ray diffraction, of the active drug and its stereoisomers. A symmetric structure in which the phenyl and methyl groups are cis about each double bond is unambiguously assigned.
KW - Dienestrol--and isomers-;
KW - Isomers--dienestrol--x-ray diffraction, structure and configuration;
KW - X-ray diffraction--dienestrol--and isomers, structure and configuration;
KW - Structure--dienestrol--and isomers, x-ray diffraction;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Waller, Salvador B
T1 - Libraries, managers, and people
JO - Special Libraries
JF - Special Libraries
Y1 - 1975/09//
VL - 66
IS - 9
M3 - Article
SP - 411
EP - 415
SN - 00386723
AB - The question of library management is receiving more and more attention. Increasing liberal attitudes on the part of workers is straining current supervisory techniques. There is evidence to suggest that current management thinking is not effective enough to deal with these changes. It is evidenced in the pressures experienced by managers and in the increasing discontent of employees. Library managers can benefit from a study of differing management theories and a greater understanding of human interactions in the work environment. They must organize that where there is poor interaction their role is causative as well as crucial.
N1 - Accession Number: ISTA1002447; Waller, Salvador B 1; Affiliations: 1 : Parklawn Health Library, Us Public Health Service, Rockville, Maryland.; Source Info: September 1975, Vol. 66 Issue 9, p411; Note: Update Code: 1000; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Jacoby, Jacob
AU - Small, Constance
T1 - The FDA Approach to Defining Misleading Advertising.
JO - Journal of Marketing
JF - Journal of Marketing
Y1 - 1975/10//
VL - 39
IS - 4
M3 - Article
SP - 65
EP - 68
PB - American Marketing Association
SN - 00222429
AB - The article reports on a method used by the U.S. Food and Drug Administration (FDA) to define and assess deceptive advertising. The author focuses on misleading advertising associated with the pharmaceutical industry in the U.S. A definition of misleading advertising is provided. It is suggested that consumers are the primary line of defense against deceptive advertising. Ambiguous terminology associated with the verbal content and context of misleading advertisements is identified and examined.
KW - MARKETING
KW - Consumer protection
KW - Advertising laws
KW - Marketing
KW - Advertising -- Government policy
KW - False advertising -- Prevention
KW - Pharmaceutical industry
KW - Drugs
KW - CORRUPT practices
KW - Drug advertising
KW - Cosmetics
KW - Food law & legislation
KW - GOVERNMENT policy
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 4996182; Jacoby, Jacob 1; Small, Constance 2; Affiliations: 1: Professor of psychological science, School of Humanities, Social Science and Education, Purdue University, West Lafayette, Indiana; 2: Psychologist, Food and Drug Administration, Washington, D.C.; Issue Info: Oct75, Vol. 39 Issue 4, p65; Thesaurus Term: MARKETING; Thesaurus Term: Consumer protection; Thesaurus Term: Advertising laws; Thesaurus Term: Marketing; Thesaurus Term: Advertising -- Government policy; Subject Term: False advertising -- Prevention; Subject Term: Pharmaceutical industry; Subject Term: Drugs; Subject Term: CORRUPT practices; Subject Term: Drug advertising; Subject Term: Cosmetics; Subject Term: Food law & legislation; Subject Term: GOVERNMENT policy; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541850 Outdoor Advertising; NAICS/Industry Codes: 541890 Other Services Related to Advertising; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Del Jones, Franklin
AU - Johnson Jr., Arnold W.
T1 - Medical and Psychiatric Treatment Policy and Practice in Vietnam.
JO - Journal of Social Issues
JF - Journal of Social Issues
Y1 - 1975///Fall1975
VL - 31
IS - 4
M3 - Article
SP - 49
EP - 65
SN - 00224537
AB - Initially contributing to the lowest incidence ever of United States combat psychiatric casualties (12/1000 per year), the preventive and treatment policies of immediacy, expectancy, simplicity, and centrality were established early in the Vietnam conflict. These policies are described, as well as a chronological view of the types of psychiatric problems encountered and a brief consideration of the "disorders of loneliness" (alcohol, drug abuse, venereal diseases). Combat versus support troop casualties are contrasted, especially in terms of the changing role of United States troops with the Vietnamization policy and withdrawal. The drug abuse epidemic revealed the inadequacy of traditional approaches and the need for developing new approaches, especially primary preventive methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Social Issues is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUALLY transmitted diseases
KW - PSYCHIATRY
KW - ALCOHOLISM
KW - DRUGS of abuse
KW - VIETNAM War, 1961-1975
KW - MILITARY medicine
KW - VIETNAM
KW - UNITED States
KW - Laos and South Vietnam
KW - Psychological factors affecting tension
KW - TENSION AND CONFLICT
N1 - Accession Number: 16476951; Del Jones, Franklin 1; Johnson Jr., Arnold W. 2; Affiliations: 1 : Walter Reed Army Medical Center.; 2 : Office of the Surgeon General, Department of the Army.; Source Info: Fall1975, Vol. 31 Issue 4, p49; Historical Period: 1960 to 1973; Subject Term: SEXUALLY transmitted diseases; Subject Term: PSYCHIATRY; Subject Term: ALCOHOLISM; Subject Term: DRUGS of abuse; Subject Term: VIETNAM War, 1961-1975; Subject Term: MILITARY medicine; Subject: VIETNAM; Subject: UNITED States; Author-Supplied Keyword: Laos and South Vietnam; Author-Supplied Keyword: Psychological factors affecting tension; Author-Supplied Keyword: TENSION AND CONFLICT; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - KACHADORIAN, WILLIAM A.
AU - WADE, JAMES B.
AU - DISCALA, VINCENT A.
T1 - Vasopressin: Induced Structural Change in Toad Bladder Luminal Membrane.
JO - Science
JF - Science
Y1 - 1975/10/03/
VL - 190
IS - 4209
M3 - Article
SP - 67
EP - 69
SN - 00368075
AB - Freeze-fracture electron microscopy demonstrates that vasopressin stimulation of isolated toad bladder alters the structure of the luminal membrane of granular cells. This alteration consists of an ordered aggression of intramembranous particles, and appears to be of functional significance, since the frequency of aggregation sites per area of membrane is closely correlated with vasopressin-induced osmotic water flow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 88002734; KACHADORIAN, WILLIAM A. 1; WADE, JAMES B. 1; DISCALA, VINCENT A. 1; Affiliations: 1: Membrane Research Laboratory, Renal Service, U.S. Public Health Service Hospital, Staten Island, New York 10304; Issue Info: 10/ 3/1975, Vol. 190 Issue 4209, p67; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wilms, Heinz G.
AU - Moss, C. Eugene
T1 - A Bookshelf on Radiological Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1975/11//
VL - 65
IS - 11
M3 - Article
SP - 1231
EP - 1237
PB - American Public Health Association
SN - 00900036
AB - The article presents a bookshelf on radiological health, which attempts to list, categorize, and present details on the many varied sources of information available to personnel's working in the field. It concentrates on those sources published or revised after 1965. It also attempts to restrict the number of sources to those more associated with public health aspects. The bookshelf is fractioned into four main sections, including textbooks, current literature, training and educational materials, and other sources. Each one of these sections is further stratified into additional details.
KW - Public health
KW - Library materials
KW - Information resources
KW - Archival materials
KW - Publishers & publishing
KW - Handbooks, vade-mecums, etc.
KW - Textbooks
KW - Medical radiology
KW - Radiology
N1 - Accession Number: 5659934; Wilms, Heinz G. 1; Moss, C. Eugene 1; Affiliations: 1: Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Rockville, Maryland 20852; Issue Info: Nov75, Vol. 65 Issue 11, p1231; Thesaurus Term: Public health; Subject Term: Library materials; Subject Term: Information resources; Subject Term: Archival materials; Subject Term: Publishers & publishing; Subject Term: Handbooks, vade-mecums, etc.; Subject Term: Textbooks; Subject Term: Medical radiology; Subject Term: Radiology; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 511190 Other publishers; NAICS/Industry Codes: 511130 Book Publishers; NAICS/Industry Codes: 511199 All Other Publishers; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Determining drug equality
CT - Determining drug equality
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1975/11/01/
VL - 9
IS - Nov
SP - 18
EP - 20
SN - 03621332
AD - HF1-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0607; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: Henri Manasse
N2 - A general discussion of bioavailability and bioequivalence, including definitions, test methods, and proposed FDA regulations, is presented.
KW - Drugs, availability--and equivalency--definitions, test methods, and FDA regulations;
KW - Equivalency--and availability--definitions, test methods, and FDA regulations;
KW - Methodology--availability--tests, discussion;
KW - Regulations--availability--and equivalency, FDA, discussion;
KW - Food and Drug Administration (U.S.)--regulations--availability, and equivalency, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Thompson, R. D.;
AU - Hoffman, T. J.;
T1 - Determination of mercury-containing pharmaceuticals by vapor phase atomic absorption spectroscopy
CT - Determination of mercury-containing pharmaceuticals by vapor phase atomic absorption spectroscopy
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/11/01/
VL - 64
IS - Nov
SP - 1863
EP - 1866
SN - 00223549
AD - Food and Drug Administration, Dept. of Health, Education, and Welfare, Minneapolis, Minnesota 55401
N1 - Accession Number: 13-3536; Language: English; Chemical Name: Thimerosal--54-64-8 Mersalyl--492-18-2 Phenylmercuric acetate--62-38-4 Chlormerodrin--62-37-3 Merbromin--129-16-8 Phenylmercuric nitrate--55-68-5 Mercuric oxide--21908-53-2 Mercury--7439-97-6; Therapeutic Class: (84:24); AHFS Class: Ointments mercuric oxide (84:24); AHFS Class: Ointments mercury; References: 22; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: Walter Howard
N2 - Vapor phase atomic absorption spectroscopy was used for the analysis of thimerosal, mersalyl with theophylline, meralluride, mercaptomerin sodium, phenylmercuric acetate, chlormerodrin tablets, merbromin, nitromersol, phenylmercuric nitrate, mercuric oxide, and yellow and ammoniated mercury. The mercurials tested were in the form of tinctures, solutions, injections, tablets and ointments. Comparative analytical data between this procedure and compendium methodology are presented.
KW - Thimerosal--spectrometry, atomic absorption-;
KW - Mersalyl--spectrometry, atomic absorption-;
KW - Meralluride--spectrometry, atomic absorption-;
KW - Mercaptomerin--sodium-;
KW - Phenylmercuric acetate--spectrometry, atomic absorption-;
KW - Chlormerodrin--spectrometry, atomic absorption-;
KW - Merbromin--spectrometry, atomic absorption-;
KW - Nitromersol--spectrometry, atomic absorption-;
KW - Phenylmercuric nitrate--spectrometry, atomic absorption-;
KW - Mercuric oxide--yellow-;
KW - Mercury--ammoniated-;
KW - Spectrometry, atomic absorption--mercury--vapor phase, dosage forms;
KW - Tinctures--mercury--derivatives, spectrometry, atomic absorption, vapor phase;
KW - Injections--mercury--derivatives, spectrometry, atomic absorption, vapor phase;
KW - Solutions--mercury--derivatives, spectrometry, atomic absorption, vapor phase;
KW - Tablets--chlormerodrin--spectrometry, atomic absorption, vapor phase;
KW - Ointments--mercuric oxide--yellow, vapor phase, atomic absorption spectrometry;
KW - Ointments--mercury--ammoniated, vapor phase, atomic absorption spectrometry;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3536&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1976-07588-001
AN - 1976-07588-001
AU - Hazell, Joseph W.
T1 - An action-insight exercise.
JF - Small Group Behavior
JO - Small Group Behavior
Y1 - 1975/11//
VL - 6
IS - 4
SP - 494
EP - 500
CY - US
PB - Sage Publications
N1 - Accession Number: 1976-07588-001. Other Journal Title: Small Group Research. Partial author list: First Author & Affiliation: Hazell, Joseph W.; US Public Health Service, Dental Health Ctr, San Francisco, CA. Release Date: 19760401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Group Dynamics; Insight. Classification: Interpersonal & Client Centered & Humanistic Therapy (3314). Population: Human (10). Page Count: 7. Issue Publication Date: Nov, 1975.
AB - Describes a structured group exercise called 'Query,' designed to achieve insight or decision-making. It is usable without a trained facilitator, and consists of the following steps: (a) a group member volunteers to be the focus; (b) each group member in turn asks the focus a question; (c) the focus responds with the truth, a lie, or a refusal to answer. Suggestions are given for questions which are productive of insight or solutions to problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - structured group exercise called 'Query
KW - ' insight & decision making
KW - 1975
KW - Decision Making
KW - Group Dynamics
KW - Insight
KW - 1975
DO - 10.1177/104649647500600410
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1976-07588-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Blamphin, John M.
T1 - PHS's challenge--to guarantee equity in health services yet not disable the institutions it affects.
JO - Geriatrics
JF - Geriatrics
Y1 - 1975/12//
VL - 30
IS - 12
M3 - Article
SP - 30
EP - 35
SN - 0016867X
N1 - Accession Number: 17741664; Blamphin, John M. 1; Source Information: Dec1975, Vol. 30 Issue 12, p30; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1353
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=17741664&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Wolters, R. J.;
AU - Bej, A. J.;
AU - Tanner, N. S.;
T1 - Conformationally constrained analogs of mescaline. 2
CT - Conformationally constrained analogs of mescaline. 2
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1975/12/01/
VL - 64
IS - Dec
SP - 2013
EP - 2014
SN - 00223549
AD - Reprints: Food and Drug Administration, HFD-110, Rockville, Maryland 20852
AD - Dept. of Pharmaceutical Chemistry and Bionucleonics, North Dakota State Univ., Fargo, North Dakota 58102
N1 - Accession Number: 13-4093; Language: English; Chemical Name: Mescaline--54-04-6; References: 4; Publication Type: Notes; Journal Coden: JPMSAE; Section Heading: Pharmaceutical Chemistry; Pharmacology
N2 - The synthesis of methyl-2-(3,4,5-trimethoxyphenyl)-2-(2-piperidyl) acetate is described. In addition, preliminary pharmacological data comparing the compound with mescaline are given.
KW - Methyl-2-(3,4,5-trimethoxyphenyl)-2-(2-piperidyl) acetate--synthesis-;
KW - Mescaline--derivatives-;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-4093&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Hooper, J K
T1 - Centralized drug list production in a multi-hospital system
JO - American Journal Of Hospital Pharmacy 33, 653-658 (1976 July). 5 Ref
JF - American Journal Of Hospital Pharmacy 33, 653-658 (1976 July). 5 Ref
Y1 - 1976///
M3 - Book Chapter
AB - A project established to maintain individualized station drug lists for a nationwide network of hospitals and clinics is described. The structure of the drug lists and procedures used in their projection are described in detail. A central location controls keypunching, data processing, and printing. The pharmacist at each station is responsible for drug list maintenance. Each station's formulary is stored on kagnetic tape. Sharing developement costs by all stations and using a single printing facility resulted in a cost-effective system.
N1 - Accession Number: ISTA1103464; Hooper, J K 1; Affiliations: 1 : Health Services Research Department, Us Public Health Service Hospital, Baltimore, Maryland; Source Info: 1976; Note: Update Code: 1100; Document Type: Book Chapter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1103464&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Eiermann, H. J.;
T1 - Cosmetic safety substantiation: regulatory considerations
CT - Cosmetic safety substantiation: regulatory considerations
JO - Drug Cosmet. Ind.
JF - Drug Cosmet. Ind.
Y1 - 1976/01/01/
VL - 118
IS - Jan
SP - 32
EP - 90
AD - Div. of Cosmetics Technology, Bureau of Foods, Food and Drug Administration, Washington, D.C.
N1 - Accession Number: 13-5751; Language: English; Journal Coden: DCINAQ; Section Heading: Toxicity; Abstract Author: Douglas L. Thompson
N2 - The principal factors that determine the safety of a cosmetic product and the steps a manufacturer should take to substantiate product safety are discussed.
KW - Cosmetics--toxicity--regulations, to substantiate safety;
KW - Toxicity--cosmetics--regulations, to substantiate safety;
KW - Regulations--cosmetics--toxicity, safety substantiation;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5751&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Belton, E. D.;
T1 - Considerations in evaluating anti-claudication agents
CT - Considerations in evaluating anti-claudication agents
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1976/01/01/
VL - 10
IS - Jan-Mar
SP - 24
EP - 26
SN - 00928615
AD - Office of Scientific Evaluation, Food and Drug Administration, Rockville, Maryland 20204
N1 - Accession Number: 13-6589; Language: English; Journal Coden: DGIJB9; Human Indicator: Yes; Section Heading: Methodology; Abstract Author: James A. Starner
N2 - Various instrumental methods for evaluating the efficacy of vasodilating agents in the treatment of the symptoms of peripheral vascular disease are briefly discussed. Of the methods tested, treadmill testing with variable inclination and speed was preferred.
KW - Vasodilating agents--peripheral vascular disease--evaluations, methodology, discussion;
KW - Methodology--vasodilating agents--peripheral vascular disease, evaluations, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-6589&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Knapp, D. E.;
AU - Baird, J. T.;
AU - Winter, W. J.;
T1 - Consumers' methods of self-medication
CT - Consumers' methods of self-medication
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1976/01/01/
VL - 10
IS - Jan-Mar
SP - 27
EP - 32
SN - 00928615
AD - Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 14-0295; Language: English; Journal Coden: DGIJB9; Section Heading: Sociology, Economics and Ethics; Abstract Author: James A. Starner
N2 - The results of a 1969 Food and Drug Administration survey investigating the public's attitudes, beliefs, and reported behaviors concerning the use of medicinal drugs in self-treatment of symptoms of illness are presented. Personal interviews were held with 2,893 adults living in private households in the continental United States. Those interviewed responded to questions on the topics of general self-medication attitudes and beliefs, self-medication for common ailments, reported diagnosis and treatment for serious ailments, and self-medication with respect to the use of laxatives and weight control products.
KW - Drug administration--self-medication--survey, consumer attitudes and beliefs;
KW - Cathartics--self-medication--survey, consumer attitudes and beliefs;
KW - Anorexics--self-medication--survey, consumer attitudes and beliefs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0295&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Cobb, W M
T1 - National drug code system: purpose and potential
JO - Hospital Formulary 11, 593-295 (1976 November)
JF - Hospital Formulary 11, 593-295 (1976 November)
Y1 - 1976///
M3 - Book Chapter
AB - The origin and purposes of the national drug code system are discussed.
N1 - Accession Number: ISTA1202449; Cobb, W M 1; Affiliations: 1 : Drug Listing Branch, Bureau Of Drugs, Food And Drug Administration, Rockville, Maryland; Source Info: 1976; Note: Update Code: 1200; Document Type: Book Chapter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1202449&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Bailey, J. E.;
AU - Cox, E. A.;
T1 - 4,4\PR/-(Diazoamino)-bis(5-methoxy-2-methylbenzenesulfonic acid): preparation and determination (high pressure liquid chromatography) in FD&C Red No. 40
CT - 4,4\PR/-(Diazoamino)-bis(5-methoxy-2-methylbenzenesulfonic acid): preparation and determination (high pressure liquid chromatography) in FD&C Red No. 40
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/01/01/
VL - 59
IS - Jan
SP - 5
EP - 1
AD - Div. of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-3534; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - FD&C Red No. 40--chromatography, liquid-;
KW - 4,4\PR/-(Diazoamino)-bis(5-methoxy-2-methylbenzenesulfonic acid)--chromatography, liquid-;
KW - Dyes--FD&C Red No. 40--chromatography, liquid, high pressure, contamination, 4,4\PR/-(diazoamino)-bis(5-methoxy-2-methylbenzenesulfonic acid);
KW - Contamination--4,4\PR/-(diazoamino)-bis(5-methoxy-2-methylbenzenesulfonic acid)--detection, high pressure, liquid chromatography, in FD&C Red No. 40;
KW - Chromatography, liquid--4,4\PR/-(diazoamino)-bis(5-methoxy-2-methylbenzesulfonic acid)--contamination, detection, high pressure, in FD&C Red No. 40;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3534&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fratz, D. D.;
AU - Bailey, J. E.;
T1 - Quantitative determination of 4,4\PR/-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6 by elution chromatography
CT - Quantitative determination of 4,4\PR/-(diazoamino)-dibenzenesulfonic acid in FD&C Yellow No. 6 by elution chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/01/01/
VL - 59
IS - Jan
SP - 12
EP - 13
AD - Div. of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-3276; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - 4,4\PR/-(Diazoamino)-dibenzenesulfonic acid--chromatography, column-;
KW - Chromatography, column--FD&C Yellow No. 6--contamination, 4,4\PR/-(diazoamino)-dibenzenesulfonic acid;
KW - Dyes--FD&C Yellow No. 6--chromatography, column, detection, 4,4\PR/-(diazoamino)-dibenzenesulfonic acid;
KW - Contamination--FD&C Yellow No. 6--4,4\PR/-(diazoamino)-dibenzenesulfonic acid, detection, column chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3276&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Detection of sulfonamides in animals feeds
CT - Detection of sulfonamides in animals feeds
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/01/01/
VL - 59
IS - Jan
SP - 56
EP - 59
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 13-3532; Language: English; Chemical Name: Sulfamerazine--127-79-7 Sulfamethazine--57-68-1 Sulfadimethoxine--122-11-2 Sulfaquinoxaline--59-40-5 Sulfadiazine--68-35-9 Sulfapyridine--144-83-2 Sulfathiazole--72-14-0 Sulfaguanidine--57-67-0; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - The thin layer chromatographic method described permits the identification of 8 sulfonamides in animal feeds, generally at the 3-10 ppm level. The detection limit varies according to the intensity of the color and the amount of fat and wax in the samples analyzed. The samples are extracted with ethyl alcohol or acetone and the extract is evaporated to dryness. Another portion of the same sample spiked at the 3 ppm level with the sulfonamides (sulfamerazine (I), sulfamethazine (II), sulfadimethoxine (III), sulfaquinoxaline (IV), sulfadiazine (V), sulfapyridine (VI), sulfathiazole (VII), and sulfaguanidine (VIII), is similarly extracted and the extract is evaporated to dryness. The residue from each solution is dispersed with 5 ml 0.1N NaOH and, following the addition of 1 ml 1N HCl and mixing, the solution is filtered. The filtrate is mixed with Celite, transferred to a column, and eluted with ammoniacal ether. Aliquots of the concentrated sample and control eluates are spotted on a neutral Adsorbosil-1 TLC plate. Following development in chloroform-methanol (95:5) and drying, the plate is sprayed with an alcoholic solution of p-dimethylaminobenzaldehyde until the control chromatogram shows 6 yellow spots which are, from top to bottom; III, the combined I, II, IV spot, V, VI, VII, and VIII. A spot on the sample chromatogram can be identified if the RF of the sample spot is approximately the same as that of the combined spot, more definite identification can be obtained by using basic TLC plates, with chloroform-methanol (92:8) as the developing solvent.
KW - Sulfamerazine--chromatography, thin layer-;
KW - Sulfamethazine--chromatography, thin layer-;
KW - Sulfadimethoxine--chromatography, thin layer-;
KW - Sulfaquinoxaline--chromatography, thin layer-;
KW - Sulfadiazine--chromatography, thin layer-;
KW - Sulfapyridine--chromatography, thin layer-;
KW - Sulfathiazole--chromatography, thin layer-;
KW - Sulfaguanidine--chromatography, thin layer-;
KW - Chromatography, thin layer--sulfamerazine--in feeds;
KW - Chromatography, thin layer--sulfamethazine--in feeds;
KW - Chromatography, thin layer--sulfadimethoxine--in feeds;
KW - Chromatography, thin layer--sulfaquinoxaline--in feeds;
KW - Chromatography, thin layer--sulfadiazine--in feeds;
KW - Chromatography, thin layer--sulfapyridine--in feeds;
KW - Chromatography, thin layer--sulfathiazole--in feeds;
KW - Chromatography, thin layer--sulfaguanidine--in feeds;
KW - Feeds--sulfonamides--chromatography, thin layer;
KW - Sulfonamides--chromatography, thin layer--in feeds;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3532&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
T1 - Detection of arsanilic acid in animal feeds
CT - Detection of arsanilic acid in animal feeds
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/01/01/
VL - 59
IS - Jan
SP - 60
EP - 61
AD - Food and Drug Administration, 2nd and Chestnut Streets, Philadelphia, Pennsylvania 19106
N1 - Accession Number: 13-3271; Language: English; Chemical Name: Arsanilic acid--98-50-0; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A thin layer chromatographic method for the detection of arsanilic acid in animal feeds is described. The sample is extracted with alcohol, the extract is evaporated to a small volume, and an aliquot is spotted on a silica gel H plate. After development of the plate in chloroform-methanol (80:20), the spotting area is scraped and extracted with ethyl alcohol, which is evaporated to dryness. The residue is dissolved in 3 ml alcohol, and an aliquot is reacted with p-dimethylaminobenzaldehyde solution; another aliquot of the extract is used as a sample blank. A control is prepared by spiking another portion of the same feed with about 5 ppm arsanilic acid. The method is applicable in the presence of procaine and sulfonamides.
KW - Arsanilic acid--chromatography, thin layer-;
KW - Chromatography, thin layer--arsanilic acid--in feeds;
KW - Feeds--arsanilic acid--chromatography, thin layer;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Fazzari, F. R.;
T1 - Collaborative study of a column chromatographic method for bendroflumethiazide and cyclothiazide
CT - Collaborative study of a column chromatographic method for bendroflumethiazide and cyclothiazide
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/01/01/
VL - 59
IS - Jan
SP - 90
EP - 92
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-3270; Language: English; Chemical Name: Bendroflumethiazide--73-48-3 Cyclothiazide--2259-96-3; References: 10; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Bendroflumethiazide (I), and cyclothiazide (II), are eluted from a sodium carbonate column with chloroform-acetic acid (98:2) and are measured directly by UV spectrophotometry. The method was collaboratively studied by 8 analysts. The average percent recovery and standard deviations for simulated mixes of I and II were 99.61 0.094 and 98.85 3.28, respectively. For commercial preparations the respective values were 99.52 0.78 and 99.3 1.97.
KW - Bendroflumethiazide--chromatography, column-;
KW - Cyclothiazide--chromatography, column-;
KW - Chromatography, column--bendroflumethiazide--and UV spectrometry;
KW - Chromatography, column--cyclothiazide--and UV spectrometry;
KW - Spectrometry, ultraviolet--bendroflumethiazide--and column chromatography;
KW - Spectrometry, ultraviolet--cyclothiazide--and column chromatography;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-3270&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Abdellah, F. G.;
AU - Chow, R. K.;
T1 - Long term care facility improvement\M/nationwide research effort
CT - Long term care facility improvement\M/nationwide research effort
JO - Journal of Long Term Care Administration (USA)
JF - Journal of Long Term Care Administration (USA)
Y1 - 1976/01/01/
VL - 4
IS - Jan
SP - 5
EP - 9
SN - 00934445
AD - U.S. Public Health Service, Dept. of HEW, Washington, D.C.
N1 - Accession Number: 13-4773; Language: English; Journal Coden: JLTAD4; Section Heading: Institutional Pharmacy Practice; Abstract Author: Jesse E. Stewart
N2 - In conjunction with the Federal Long Term Care Facility Improvement Campaign, a survey of the current status of care in this nation's skilled nursing facilities was undertaken to collect baseline data. A two stage stratified random sampling design was used to select a sample from 7,526 skilled nursing facilities participating in the Medicare/Medicaid programs in 1974. The following areas are summarized: patient characteristics; health care needs of patients and residents; nutritional needs; pharmaceutical services; physician services; rehabilitative services; administrative and fiscal management; health and safety of the environment; social services; and, training. It is concluded that most facilities are well on their way toward achieving the capacity to render pharmaceutical services in accordance with accepted professional practices; that efforts should be made to institute direct order systems for physician drug orders; and, that the issue of appropriate reimbursement of the pharmacist needs to be studied.
KW - Long term care facilities--pharmacy--services, survey;
KW - Pharmacy--services--long term care facilities, survey;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-4773&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Weber, J. D.;
T1 - Single tablet enantiomeric purity assay of amphetamine by rotation enhancement
CT - Single tablet enantiomeric purity assay of amphetamine by rotation enhancement
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/01/01/
VL - 65
IS - Jan
SP - 105
EP - 108
SN - 00223549
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 13-4682; Language: English; Chemical Name: Dextroamphetamine--51-64-9; References: 14; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Enhancement of the optical rotation of dextroamphetamine (I) by production of an optically active chromophore through reaction with 1-fluoro-2,4-dinitrobenzene to give \a/-methyl-N-(2,4-dinitrophenyl)-\B/- phenylethylamine is reported, and its usefulness in an assay procedure is noted. This colorimetric reaction forms the basis of an assay for both the content and optical purity of I at single dose levels (5 mg). Results of assays of standard solutions and of commercial tablets demonstrate the suitability of the method for the determination of enantiomeric purity and amphetamine content.
KW - Dextroamphetamine--colorimetry-;
KW - Colorimetry--dextroamphetamine--enantiomers, optical purity, tablets;
KW - Enantiomers--dextroamphetamine--colorimetry, optical purity, tablets;
KW - Tablets--dextroamphetamine--colorimetry, optical purity, and enantiomers;
KW - Purity--dextroamphetamine--optical, colorimetry, enantiomers, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Lechnyr, Ronald J.
T1 - Learn from the Teachers.
JO - Social Work
JF - Social Work
Y1 - 1976/01//
VL - 21
IS - 1
M3 - Article
SP - 75
PB - Oxford University Press / USA
SN - 00378046
AB - The article presents a commentary on the changes in education recommended by the Council of Social Work Education and how they will affect the social work profession. It provides reason for the willingness of administrators of agencies to keep salaries low and growth of master's degree programs in social work. It also focuses on the development of a social work practice and the conversion of master's degrees into doctoral degrees on a retroactive basis. The rapid growth of master's degree programs in social work is outstripped only by the rapid growth of BSW programs. Though this will encourage the hiring of BSWs, even in public welfare agencies, it is also probable that these BSWs will be hired at various levels, since employers are essentially not familiar with the variety of training programs and specializations within the field of social work. As a result the more highly trained people will be forced into other areas of practice or unemployment. It is doubtful that most employers would be willing to pay the salary demanded by doctoral degree holders who want to enter the practice field.
KW - SOCIAL services
KW - SOCIAL work education
KW - INCOME
KW - WAGES
KW - OCCUPATIONAL training
KW - HUMAN services
KW - PUBLIC welfare
N1 - Accession Number: 5267637; Lechnyr, Ronald J. 1; Source Information: Jan76, Vol. 21 Issue 1, p75; Subject: SOCIAL services; Subject: SOCIAL work education; Subject: INCOME; Subject: WAGES; Subject: OCCUPATIONAL training; Subject: HUMAN services; Subject: PUBLIC welfare; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Bakers, Lawrence D.
AU - Yert, Louise W.
AU - Chase, Mary C.
AU - Dale, Edwin
T1 - Evaluation of a 'Do-It-Yourself' Pregnancy Test.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/02//
VL - 66
IS - 2
M3 - Article
SP - 166
PB - American Public Health Association
SN - 00900036
AB - The article presents information on the evaluation of the Ova II Preliminary Screening Test for pregnancy. It was evaluated by comparing the result with standard laboratory tests for urinary chorionic gonadotrophin. The test is performed to determine both its theoretical and use effectiveness. Theoretical effectiveness was defined as the accuracy of the test when performed by professional laboratory personnel according to the manufacturer's instructions. In contrast , use effectiveness was as the accuracy of the product when performed by the untrained consumer. Participants were admitted to Grady Memorial Hospital for a suction curettage outpatient abortion, and employees of the U.S. Center for Disease Control who at the time of the pregnancy test believed themselves not pregnant.
KW - HEALTH
KW - Birth control
KW - Public health
KW - Pregnancy
KW - Diagnosis
KW - Gonadotropin
KW - Women
KW - Women employees
KW - Vacuum curettage
KW - United States
N1 - Accession Number: 5666029; Bakers, Lawrence D. 1,2; Yert, Louise W. 1,2; Chase, Mary C. 1,2; Dale, Edwin 1,2; Affiliations: 1: Department of Health, Education and Welfare, Public Health Service, Center for Disease Control, Bureau of Epidemiology; 2: Department of Gynecology and Obstetries Emory University School of Medicine, Atlanta, GA.; Issue Info: Feb1976, Vol. 66 Issue 2, p166; Thesaurus Term: HEALTH; Thesaurus Term: Birth control; Thesaurus Term: Public health; Subject Term: Pregnancy; Subject Term: Diagnosis; Subject Term: Gonadotropin; Subject Term: Women; Subject Term: Women employees; Subject Term: Vacuum curettage; Subject: United States; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Panel reports on sleep aids
CT - Panel reports on sleep aids
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/02/01/
VL - 10
IS - Feb
SP - 10
EP - 13
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0453; Language: English; Chemical Name: Caffeine--58-08-2; Journal Coden: FDACBH; Section Heading: Drug Evaluations; Abstract Author: Henri Manasse, Jr.
N2 - A discussion of the Food and Drug Administration panel report on over-the counter sleep aids, daytime sedatives and stimulants is presented. Except for antihistamines, all sleep aid ingredients were found to be ineffective. Caffeine was the only stimulant found to be safe and effective.
KW - Caffeine--drugs, over-the-counter-;
KW - Drugs, over-the-counter--sedatives and hypnotics--and central nervous system stimulants, FDA panel report on safety and effectiveness;
KW - Sedatives and hypnotics--drugs, over-the-counter--and central nervous system stimulants, FDA panel report on safety and effectiveness;
KW - Central nervous system stimulants--drugs, over-the-counter--and sedatives and hypnotics, FDA panel report on safety and effectiveness;
KW - Antihistamines--sedatives and hypnotics--central nervous system stimulants, FDA panel report on safety and effectiveness;
KW - Rational therapy--sedatives and hypnotics--over-the-counter, FDA panel report;
KW - Rational therapy--central nervous system stimulants--over-the-counter, FDA panel report;
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DP - EBSCOhost
DB - ipa
ER -
TY - NEWS
AU - Brown, Bertram S.
T1 - How do mental health and aging affect each other? New center will encourage search for answers.
JO - Geriatrics
JF - Geriatrics
Y1 - 1976/02//
VL - 31
IS - 2
M3 - Editorial
SP - 40
EP - 44
SN - 0016867X
N1 - Accession Number: 17208317; Brown, Bertram S. 1,2; Source Information: Feb1976, Vol. 31 Issue 2, p40; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1383
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Turczan, J. W.;
AU - Medwick, T.;
T1 - NMR analysis of pharmaceuticals. 14. Determination of amyl nitrite in its inhalant dosage form
CT - NMR analysis of pharmaceuticals. 14. Determination of amyl nitrite in its inhalant dosage form
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/02/01/
VL - 65
IS - Feb
SP - 235
EP - 238
SN - 00223549
AD - Food and Drug Administration, Dept. of Health, Education, and Welfare, Brooklyn, New York 11232
N1 - Accession Number: 13-4103; Language: English; Chemical Name: Amyl nitrite--110-46-3; Journal Coden: JPMSAE; Section Heading: Drug Analysis
KW - Amyl nitrite--spectrometry, nuclear magnetic resonance-;
KW - Spectrometry, nuclear magnetic resonance--amyl nitrite--dosage forms, inhalation;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Sheinin, E. B.;
AU - Benson, W. R.;
AU - Brannon, W. L.;
T1 - Determination of methyl methacrylate in surgical acrylic cement
CT - Determination of methyl methacrylate in surgical acrylic cement
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/02/01/
VL - 65
IS - Feb
SP - 280
EP - 283
SN - 00223549
AD - Div. of Drug Chemistry (HFD-420), Food and Drug Administration, U.S. Dept. of H.E. W., Washington, D.C. 20204
N1 - Accession Number: 13-4382; Language: English; Chemical Name: Methyl methacrylate--80-62-6; References: 18; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - A methyl methacrylate (I) cement used in hip surgery as well as in dentistry was identified and quantitatively analyzed for its monomer content in starting materials and in the finished cement by proton magnetic resonance spectroscopy. IR data indicated that the monomer continued to escape from the product after it had hardened. The presence of 21% I monomer relative to the polymer was demonstrated at the time the cement normally would be inserted into the body.
KW - Methyl methacrylate--cements-;
KW - Cements--methyl methacrylate--leaching, IR spectrometry;
KW - Spectrometry, infrared--methyl methacrylate--cements, leaching;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Barkdoll, Gerald L.
T1 - Making Planning Relevant to Public Agency Management.
JO - Long Range Planning
JF - Long Range Planning
Y1 - 1976/02//
VL - 9
IS - 1
M3 - Article
SP - 59
EP - 65
SN - 00246301
AB - The special considerations of planning in the public area have exercised many minds during the last decade. In this article the author reports on the particular experience of the (U.S.) Food and Drug Administration (FDA) from the initiation of a new planning system in 1972 to 1975. The lessons learned and the conclusions drawn from this experience are described in the article, many of which will have relevance to public sector planning in other environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Long Range Planning is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Government agencies
KW - Executive departments
KW - Government agencies -- Management
KW - Public sector
KW - Business planning
KW - Public administration
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 5506038; Barkdoll, Gerald L. 1; Affiliations: 1: Assistant Commissioner for Planning and Evaluation, Food and Drug Administration, Department of Health, Education, and Welfare; Issue Info: Feb76, Vol. 9 Issue 1, p59; Subject Term: Government agencies; Subject Term: Executive departments; Subject Term: Government agencies -- Management; Subject Term: Public sector; Subject Term: Business planning; Subject Term: Public administration; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 921110 Executive Offices; Number of Pages: 7p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Abdellah, Faye G.
T1 - Nurse Practitioners and Nursing Practice.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/03//
VL - 66
IS - 3
M3 - Editorial
SP - 245
PB - American Public Health Association
SN - 00900036
AB - The article reflects on the expanded role of nurse practitioners in the health care delivery system in the U.S. The author contends that the role of professional nurses is expanding to include broader functions in the realm of nursing practice which sometimes overlap the responsibilities of the physicians. She comments on the doubtless innovative changes in the systems of nursing education and stresses the significance of nurses in achieving improved health care for all Americans.
KW - Nursing service administration
KW - Nursing -- Law & legislation
KW - Nurse practitioners
KW - Nurses -- United States
KW - Medical care -- United States
KW - United States
N1 - Accession Number: 5672457; Abdellah, Faye G. 1,2,3; Affiliations: 1: Assistant Surgeon General, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852.; 2: Chief Nurse Officer, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852.; 3: Director, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852.; Issue Info: Mar1976, Vol. 66 Issue 3, p245; Subject Term: Nursing service administration; Subject Term: Nursing -- Law & legislation; Subject Term: Nurse practitioners; Subject Term: Nurses -- United States; Subject Term: Medical care -- United States; Subject: United States; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Informing patients on prescription drugs
CT - Informing patients on prescription drugs
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/03/01/
VL - 10
IS - Mar
SP - 4
EP - 7
SN - 03621332
AD - HF1-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0629; Language: English; Journal Coden: FDACBH; Section Heading: Information Processing and Literature; Abstract Author: Henri Manasse
N2 - A discussion of patient package inserts and their potential effects on patient understanding of compliance, side effects and risks associated with prescription drugs is presented.
KW - Patient information--package inserts--effects, potential, on understanding of drug therapy;
KW - Package inserts--patients--effects, potential, on understanding of drug therapy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Larkin, T.;
T1 - Mixing medicines? Have a care!
CT - Mixing medicines? Have a care!
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/03/01/
VL - 10
IS - Mar
SP - 8
EP - 1
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0479; Language: English; Journal Coden: FDACBH; Human Indicator: Yes; Section Heading: Drug Interactions; Sociology, Economics and Ethics; Abstract Author: Henri Manasse
N2 - A consumer oriented discussion on drug interactions, including potentiation, interference, and drug-laboratory test interactions, is presented.
KW - Drug interactions--discussion--consumer oriented;
KW - Tests, laboratory--interactions--drugs, consumer oriented information;
KW - Rational therapy--drug interactions--in combined therapy, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - What drug price ads must tell
CT - What drug price ads must tell
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/03/01/
VL - 10
IS - Mar
SP - 18
EP - 19
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0605; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: Henri Manasse
N2 - Regulations stating that all drug advertisements must include: (1) brand and generic names; (2) strength and dosage form; and (3) complete price for a specific quantity, are discussed.
KW - Regulations--advertising--drugs, information needed;
KW - Advertising--regulations--drugs, information needed;
KW - Drug information--advertising--regulations, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Nelson, J. J.;
T1 - Quantitation of \LC/o\UC/- and \LC/p\UC/-sulfamoylbenzoic acids in commercial saccharin by high performance liquid chromatography
CT - Quantitation of \LC/o\UC/- and \LC/p\UC/-sulfamoylbenzoic acids in commercial saccharin by high performance liquid chromatography
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/03/01/
VL - 59
IS - Mar
SP - 243
EP - 250
AD - Food and Drug Administration, 850 Third Ave., Brooklyn, New York 11232
N1 - Accession Number: 13-4998; Language: English; Chemical Name: Saccharin--81-07-2; References: 23; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Quantitation of o- and p-sulfamoylbenzoic acid residues in saccharin and its sodium salt is achieved by a method comprising methanolic extraction and high performance ion exchange chromatography. An anion exchange column was employed with an aqueous buffered (pH 9.2) mobile phase. As little as 80 ppm of the ortho isomer and 25 ppm of the para isomer can be accurately determined. The levels of detectability (2 times noise) are estimated as 8 ppm (0.16 mcg on column) and 2.5 ppm (0.05 mcg on column), respectively. Recoveries from saccharin ranged from 92.7 to 96.5% (ortho) and from 92.2 to 103.3% (para). Recoveries from the sodium salt ranged from 93.1 to 104.4% (ortho) and from 93.5 to 97.8% (para). Of 9 other potential saccharin impurities tested separately, only one was found to interfere slightly in the chromatographic part of the procedure.
KW - Saccharin--chromatography, liquid-;
KW - Sulfamoylbenzoic acid--ortho and para-;
KW - Chromatography, liquid--saccharin--high performance, quantitation of o- and p-sulfamoylbenzoic acid;
KW - Sweetening agents--saccharin--chromatography, liquid, high performance, quantitation of o- and p-sulfamoylbenzoic acid;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kreienbaum, M. A.;
T1 - Collaborative study of a semi-automated fluorometric method for the determination of reserpine in tablets
CT - Collaborative study of a semi-automated fluorometric method for the determination of reserpine in tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1976/03/01/
VL - 59
IS - Mar
SP - 289
EP - 292
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 13-4996; Language: English; Chemical Name: Reserpine--50-55-5; References: 3; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A semi-automated fluorometric method for the determination of reserpine in tablets was collaboratively studied by 7 laboratories. The method is a modification of the semi-automated method of Urbanyi and Stober, which involves formation of a fluorogen with vanadium pentoxide. Collaborators were supplied with 3 composites, each from a different dosage level of commercial tablets. The results obtained agreed well with the AOAC manual fluorometric method; coefficients of variation ranged from 0.45 to 2.70%.
KW - Reserpine--fluorometry-;
KW - Fluorometry--reserpine--tablets, semi-automated;
KW - Tablets--reserpine--fluorometry, semi-automated;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1976-24543-001
AN - 1976-24543-001
AU - Shevitz, Stewart A.
T1 - Psychosurgery: Some current observations.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1976/03//
VL - 133
IS - 3
SP - 266
EP - 270
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1976-24543-001. PMID: 1259036 Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Shevitz, Stewart A.; Public Health Service Indian Hosp, Tuba City, AZ. Release Date: 19760901. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Disorders; Mental Disorders; Professional Ethics; Psychosurgery. Classification: Specialized Interventions (3350). Population: Human (10). Page Count: 5. Issue Publication Date: Mar, 1976.
AB - The term psychosurgery encompasses a wide variety of neurosurgical procedures applied in the treatment of behavioral and psychiatric disorders. It is pointed out that arguments about the effectiveness and ethicality of psychosurgery are often based on studies using outdated procedures or inappropriate patient populations. The debate over psychosurgery is also obscured by the frequent confusion between its use in classical psychiatric syndromes and in such controversial areas as aggression or violent behavior associated with temporal lobe epilepsy. It is recommended that such factors be clarified so that practitioners can choose a personal position based on sound medical fact. (32 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evaluation of merits of psychosurgery in treatment of behavioral & psychiatric disorders
KW - 1976
KW - Behavior Disorders
KW - Mental Disorders
KW - Professional Ethics
KW - Psychosurgery
KW - 1976
DO - 10.1176/ajp.133.3.266
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1976-24543-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chopra, Joginder G.
T1 - Current Regulatory Status of Foods For Special Dietary Uses.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/04//
VL - 66
IS - 4
M3 - Article
SP - 351
PB - American Public Health Association
SN - 00900036
AB - The Food and Drug Administration has redefined foods for "special dietary use". Such foods must now: (1) Supply a special dietary need that exists by reason of a physical or physiological condition, such as convalescence, a pregnancy, lactation, or by reason of a specific disease or disorder; (2) Supply a vitamin, mineral, or other dietary property to supplement diet by increasing total dietary intake; (3) Meet a special nutritional need as the sole item of the diet. The stricter definition of this category of food means that the conventional foods with added nutrients or food for which nutritional claims are made or nutritional information provided will no longer be considered as foods for special dietary uses, although they must conform to standard nutritional labeling requirements. The new regulation establishes a clearly delineated position within which the consumer, industry, and FDA can deal with special dietary foods without the past confusion as to what belonged in this category. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food law & legislation
KW - Food labeling
KW - Dietary supplements
KW - Food additives
KW - Pantothenic acid
KW - Breastfeeding (Humans)
KW - Diet therapy
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 5666149; Chopra, Joginder G. 1; Affiliations: 1: Special Assistant for Medical Affairs, Office of Nutrition and Consumer Sciences, Bureau of Foods, Food and Drug Administration.; Issue Info: Apr1976, Vol. 66 Issue 4, p351; Thesaurus Term: Food law & legislation; Thesaurus Term: Food labeling; Thesaurus Term: Dietary supplements; Thesaurus Term: Food additives; Subject Term: Pantothenic acid; Subject Term: Breastfeeding (Humans); Subject Term: Diet therapy; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Pines, W.;
T1 - Women and estrogens
CT - Women and estrogens
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/04/01/
VL - 10
IS - Apr
SP - 4
EP - 8
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0384; Language: English; Journal Coden: FDACBH; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Henri Manasse
N2 - A discussion of estrogen use in menopausal women, lack of therapeutic evidence and the possible connection between overuse and uterine cancer is presented.
KW - Estrogens--rational therapy--and toxicity, discussion;
KW - Rational therapy--estrogens--and toxicity, menopausal women, discussion;
KW - Toxicity--estrogens--and rational therapy, menopausal women, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Infante, P. F.;
AU - McMichael, A. J.;
AU - Wagoner, J. K.;
AU - Waxweiler, R. J.;
AU - Falk, H.;
T1 - Genetic risks of vinyl chloride
CT - Genetic risks of vinyl chloride
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/04/03/
VL - 1
IS - Apr 3
SP - 734
EP - 735
SN - 00237507
AD - Reprints: N.I.O.S.H., P.O. Bldg., Rm. 515, Cincinnati, Ohio 45202
AD - Div. of Surveillance, Hazard Evaulations and Field Studies, National Institute for Occupational Safety and Health, Bureau of Epidemiology, Center for Disease Control; and School of Public Health, Univ. of North Carolina
N1 - Accession Number: 13-4716; Language: English; Chemical Name: Vinyl chloride--75-01-4; References: 13; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Environmental Toxicity
N2 - A study of pregnancy outcome among wives of workers exposed to vinyl chloride monomer (I) indicated that, in comparison with controls, there was a significant excess fetal loss in the group whose husbands had a primary exposure to I, whereas no differences between the groups were observed before the husbands' exposures. The difference in fetal death rates for the post-exposure comparisons was a reflection of a greater fetal loss associated with the wives' younger aged husbands. The significant excess did not seem to be the result of bias from interviewers, respondents, nor from women who had experienced chronic abortions weighting the results. These findings, in conjunction with the demonstration of a mutagenic response via microbial test systems and with observations of significant excesses of chromosomal aberrations among workers exposed to I, raise scientific and public health concern for the possible genetic risks of I to man.
KW - Vinyl chloride--toxicity, environmental-;
KW - Toxicity, environmental--vinyl chloride--fetal loss, following paternal exposure, in humans;
KW - Pharmacogenetics--vinyl chloride--fetal loss, following paternal exposure, in humans;
KW - Metabolism--vinyl chloride--fetal loss, following paternal exposure, in humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-4716&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Mallov, J. S.;
T1 - Methyl N-butyl ketone (MBK) neuropathy among spray painters
CT - Methyl N-butyl ketone (MBK) neuropathy among spray painters
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/04/05/
VL - 235
IS - Apr 5
SP - 1455
EP - 1457
AD - National Institute for Occupational Safety and Health, Div. of Field Studies and Clinical Investigations, Cincinnati, Ohio) (Reprints: Dept. of Medicine, Montefiore-Univ. of Pittsburgh Hospital, 3459 Fifth Ave., Pittsburgh, Pennsylvania 15213
N1 - Accession Number: 13-4718; Language: English; References: 14; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Environmental Toxicity; Abstract Author: Joan Lentine
N2 - Three cases are presented which suggest that the solvent methyl N-butyl ketone may be responsible for peripheral neuropathy in spray painters.
KW - Methyl N-butyl ketone--toxicity, environmental-;
KW - Toxicity, environmental--methyl N-butyl ketone--neuropathy, peripheral, in spray painters;
KW - Solvents--methyl N-butyl ketone--neuropathy, peripheral, in spray painters;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - HEALY, GEORGE R.
AU - SPIELMAN, ANDREW
AU - GLEASON, NEVA
T1 - Human Babesiosis: Reservoir of Infection on Nantucket Island.
JO - Science
JF - Science
Y1 - 1976/04/30/
VL - 192
IS - 4238
M3 - Article
SP - 479
EP - 480
SN - 00368075
AB - Examination of blood films from six species of rodents and lagomorphs on Nantucket Island disclosed infections with Babesia microti in all of five Microtus pennsylvanicus (field mice) and 31 of 39 Peromyscus leucopus (white-footed or deer mice). Six human cases of clinical babesiosis have recently been diagnosed on the island. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85360759; HEALY, GEORGE R. 1; SPIELMAN, ANDREW 2; GLEASON, NEVA 3; Affiliations: 1: Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333; 2: Department of Tropical Public Health, Harvard University School of Public Health, Boston, Massachusetts 02115; 3: Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta; Issue Info: 4/30/1976, Vol. 192 Issue 4238, p479; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Pines, W.;
T1 - Women and the pill
CT - Women and the pill
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/05/01/
VL - 10
IS - May
SP - 16
EP - 21
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0382; Language: English; Journal Coden: FDACBH; Human Indicator: Yes; Section Heading: Toxicity; Pharmacology; Abstract Author: Henri Manasse
N2 - A discussion of estrogen use as oral contraceptives and the risk of adverse reactions, including blood clots, liver tumors, uterine cancer and nausea, is presented. Possible fetal effects in pregnant women were also discussed.
KW - Estrogens--contraceptives, oral--rational therapy, and toxicity, discussion;
KW - Contraceptives, oral--estrogens--rational therapy, and adverse reactions, discussion;
KW - Toxicity--estrogens--and rational therapy, discussion;
KW - Rational therapy--estrogens--and toxicity, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Grunspan, Marcel
AU - THomas, Michael E.
T1 - A Theory of Public Bureaucracy, Politics, Personality, and Organization in the State Department.
JO - Interfaces
JF - Interfaces
Y1 - 1976/05//
VL - 6
IS - 3
M3 - Book Review
SP - 86
EP - 87
PB - INFORMS: Institute for Operations Research
SN - 00922102
AB - Reviews the book "A Theory of Public Bureaucracy, Politics, Personality and Organization in the State Department," by Donald P. Warwick.
KW - BUREAUCRACY
KW - NONFICTION
KW - WARWICK, Donald P.
KW - THEORY of Public Bureaucracy: Politics, Personality & Organization in the State Department, A (Book)
N1 - Accession Number: 6692105; Grunspan, Marcel 1; THomas, Michael E.; Affiliations: 1: Food and Drug Administration.; Issue Info: May76, Vol. 6 Issue 3, p86; Thesaurus Term: BUREAUCRACY; Subject Term: NONFICTION; Reviews & Products: THEORY of Public Bureaucracy: Politics, Personality & Organization in the State Department, A (Book); People: WARWICK, Donald P.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - ent
ER -
TY - JOUR
ID - 1976-26381-001
AN - 1976-26381-001
AU - Schneidman, Barbara
AU - McGuire, Linda
T1 - Group therapy for nonorgasmic women: Two age levels.
JF - Archives of Sexual Behavior
JO - Archives of Sexual Behavior
JA - Arch Sex Behav
Y1 - 1976/05//
VL - 5
IS - 3
SP - 239
EP - 247
CY - Germany
PB - Springer
SN - 0004-0002
SN - 1573-2800
N1 - Accession Number: 1976-26381-001. PMID: 986133 Partial author list: First Author & Affiliation: Schneidman, Barbara; US Public Health Service Hosp, Dept of Obstetrics & Gynecology, Seattle, WA. Release Date: 19761001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Female Orgasm; Group Psychotherapy; Human Females. Classification: Group & Family Therapy (3313). Population: Human (10); Female (40). Page Count: 9. Issue Publication Date: May, 1976.
AB - Employed a group method of therapy for the treatment of primary orgasmic dysfuncton in 10 women below and 10 women above 35 yrs of age to determine the appropriateness of this therapy for younger and older females. The treatment combined a W. H. Masters and V. E. Johnson (1970) style of behavioral and self-stimulation therapy. At termination, 70% of the younger women were orgasmic, with 80% orgasmic at 6-mo follow-up. None were coitally orgasmic. 40% of the older women were orgasmic at therapy termination, with 60% orgasmic at 6-mo follow-up. One woman was orgasmic during intercourse. There was general enhancement of the sexual relationship in all participating couples. It is concluded that group therapy may be less successful for older women, who may be more successfully treated individually. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - group therapy
KW - primary orgasmic dysfunction
KW - women above vs below age 35
KW - 1976
KW - Age Differences
KW - Female Orgasm
KW - Group Psychotherapy
KW - Human Females
KW - 1976
DO - 10.1007/BF01541375
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Herrmann, K. L.;
AU - Halstead, S. B.;
AU - Brandling-Bennett, A. D.;
AU - Witte, J. J.;
AU - Wiebenga, N. H.;
AU - \ET/;
T1 - Rubella immunization: persistence of antibody four years after a large scale field trial
CT - Rubella immunization: persistence of antibody four years after a large scale field trial
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1976/05/17/
VL - 235
IS - May 17
SP - 2201
EP - 2204
AD - Center for Disease Control, Public Health Service, Atlanta, Georgia 30333
N1 - Accession Number: 13-4878; Language: English; References: 14; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A long-term comparative field trial of 3 live, attenuated rubella vaccines (HPV-77 DE-5, HPV-77 DK-12, and Cendehill) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. Rubella hemagglutination inhibition tests on prevaccination serum specimens from 7,931 children in the 2 study areas indicated an overall susceptibility to rubella of nearly 70%. The rates of seroconversion of 5,153 seronegative subjects to HPV-77 DE-5, HPV-77 DK-12, and Cendehill vaccine were 97.5%, 99.9%, and 99.8%, respectively. Over the subsequent 4-yr follow-up period, during which time natural exposure to rubella was minimal, the percent decline of geometric mean titers did not vary substantially among the 3 vaccine groups and measured about 2 fold for all 3. A total of only 28 vaccinees (0.7%) who seroconverted to one of the vaccines in 1969 lost all measurable antibody by 1974. Measurable antibody persisted in more than 98% of all vaccinees over the 4-yr period. Reinfection, thought possibly to be an important factor in maintaining titers, did not occur frequently in the study population and could not be related to outbreaks of disease.
KW - Rubella vaccines--immunization-;
KW - Immunization--rubella--vaccines, antibody persistence, in children;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Levine, Richard J.
AU - Moore Jr., Roscoe M.
AU - McLaren, Gordon D.
AU - Barthel, William F.
AU - Landrigan, Philip J.
T1 - Occupational Lead Poisoning, Animal Deaths, and Environmental Contamination at a Scrap Smelter.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/06//
VL - 66
IS - 6
M3 - Article
SP - 548
PB - American Public Health Association
SN - 00900036
AB - Occupational lead poisoning and environmental contamination were evaluated at a lead scrap smelter. Thirty of 37 employees (81 percent) had blood lead levels of ≥ 8O μg/100ml, indicating unacceptable absorption, and 35 had free erythrocyte protoporphyrin (FEP) levels >60 μg/100ml rbc, indicating toxicity of lead on heme metabolism in red blood cells; eight current and previous employees had been hospitalized with lead colic, and another with encephalopathy. Levels of lead in surface soil(1,800 ppm) and vegetation (20,000 ppm) at the smelter were high and decreased with distance. Animals on nearby pasture had died, and lead levels in the blood, milk, and hair of large and small animals were elevated. Adults living within 100 meters of the smelter had higher blood and hair lead levels than controls, who lived at greater distances, but there was no evidence in them of lead toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lead poisoning
KW - Pollutants
KW - Lead -- Toxicology
KW - Public health
KW - Employees
KW - Erythrocytes
KW - Hepatic encephalopathy
KW - Automobile batteries
KW - United States
N1 - Accession Number: 5666080; Levine, Richard J. 1; Moore Jr., Roscoe M. 1; McLaren, Gordon D. 1; Barthel, William F. 1; Landrigan, Philip J. 1; Affiliations: 1: Bureau of Epidemiology and Bureau of Laboratories, U.S. Dept. of Health, Education, and Welfare, Public Health Service, Center for Disease Control, Atlanta, GA.; Issue Info: Jun76, Vol. 66 Issue 6, p548; Thesaurus Term: Lead poisoning; Thesaurus Term: Pollutants; Thesaurus Term: Lead -- Toxicology; Thesaurus Term: Public health; Subject Term: Employees; Subject Term: Erythrocytes; Subject Term: Hepatic encephalopathy; Subject Term: Automobile batteries; Subject: United States; NAICS/Industry Codes: 441310 Automotive Parts and Accessories Stores; NAICS/Industry Codes: 415290 Other new motor vehicle parts and accessories merchant wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Handsfield, H. H.;
AU - Wiesner, P. J.;
AU - Holmes, K. K.;
T1 - Treatment of the gonococcal arthritis-dermatitis syndrome
CT - Treatment of the gonococcal arthritis-dermatitis syndrome
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1976/06/01/
VL - 84
IS - Jun
SP - 661
EP - 667
SN - 00034819
AD - Reprints: Dept. of Medicine, Orange County Medical Center, 101 City Drive South, Orange, California 92668
AD - Dept. of Medicine, Univ. of Washington School of Medicine, and Public Health Service Hospital, Seattle, Washington
N1 - Accession Number: 14-0106; Language: English; Chemical Name: Ampicillin--69-53-4 Penicillin G--61-33-6; References: 13; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Teresa A. Dunlap
N2 - A 32 month prospective study of several antibiotics for therapy of the gonococcal arthritis-dermatitis syndrome in 98 patients, ages 15-52 is presented. For the first 22 months patients with suspected disseminated gonococcal infection received IV penicillin G 10 million units for 1-10 days followed by oral ampicillin (I) 2 g/day to complete 10 days total therapy. During the final 10 months of the study, 29 patients were given an oral loading dose of 3.5 g I together with one of probenecid, followed by 500 mg of I given 4 times daily, for 7-14 days. Throughout the study 36 patients received other antibiotic regimens: lower dose parenteral penicillin, oral tetracycline, parenteral cephalosporins and other miscellaneous regimens. The patients were evaluated daily to ascertain rate of improvement of subjective and objective abnormalities. After discharge, patients returned weekly until asymptomatic, then 6 weeks, and 3, 6, and 12 months after initiation of therapy. The resolution of joint pathology was found to be more closely related to the critical presence or absence of a purulent synovial effusion than to the antibiotic regimen used for treatment. Patients with purulent effusions recovered more slowly. There is a caution that while oral I is effective, it should not be used on an outpatient basis unless the possibility of endocarditis and meningitis has been thoroughly ruled out, and never if the patient has purulent effusions requiring supportive care. Problems of noncompliance are noted. It is concluded that both oral I and intravenous penicillin G followed by oral I are co-equal first choice regimens on an inpatient basis for the treatment of uncomplicated disseminated gonococcal infection.
KW - Ampicillin--alone and with penicillin G-;
KW - Penicillin G--alone and with ampicillin-;
KW - Rational therapy--ampicillin--alone and with penicillin G, oral and IV, gonococcal arthritis-dermatitis syndrome, patients;
KW - Rational therapy--penicillin G--alone and with ampicillin, oral and IV, gonococcal arthritis-dermatitis syndrome, patients;
KW - Drug administration--routes--ampicillin, alone and with penicillin G, oral and IV, rational therapy, gonococcal arthritis-dermatitis syndrome, patients;
KW - Combined therapy--ampicillin and penicillin G--oral, and IV, gonococcal arthritis-dermatitis syndrome, patients;
KW - Combined therapy--penicillin G and ampicillin--oral, and IV, gonococcal arthritis-dermatitis syndrome, patients;
KW - Antibiotics--rational therapy--syndromes, gonococcal arthritis-dermatitis, oral and IV, patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0106&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bruch, C. W.;
T1 - Microbiological quality assurance of eye products
CT - Microbiological quality assurance of eye products
JO - Drug Cosmet. Ind.
JF - Drug Cosmet. Ind.
Y1 - 1976/06/01/
VL - 118
IS - Jun
SP - 49
EP - 62
AD - Div. of Classification and Scientific Evaluation, Bureau of Medical Devices and Diagnostic Products, Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 13-5963; Language: English; References: 26; Journal Coden: DCINAQ; Section Heading: Legislation, Laws and Regulations; Pharmaceutical Technology; Abstract Author: Douglas L. Thompson
N2 - The fungal contamination of ophthalmic products is discussed as is the role of the Bureau of Medical Devices and Diagnostic Products (FDA) in ensuring a product's sterility.
KW - Solutions, ophthalmic--contamination--fungi, prevention, FDA regulations;
KW - Control, quality--solutions, ophthalmic--contamination, fungi, prevention, FDA regulations;
KW - Food and Drug Administration (U.S.)--Bureau of Medical Devices and Diagnostic Products--role, assuring sterility of eye products;
KW - Devices--ophthalmic--contamination, fungi, prevention, FDA regulations;
KW - Regulations--ophthalmic preparations--sterility, discussion, FDA viewpoint;
KW - Ophthalmic preparations--sterility--prevention, fungal contamination, FDA regulations;
KW - Contamination--ophthalmic preparations--fungi, prevention, FDA regulations;
KW - Sterility--ophthalmic preparations--regulations, FDA, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Drug labels: the consumers view
CT - Drug labels: the consumers view
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/06/01/
VL - 10
IS - Jun
SP - 11
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0628; Language: English; Journal Coden: FDACBH; Section Heading: Information Processing and Literature; Abstract Author: Henri Manasse
N2 - An FDA study to determine the public's reaction to nonprescription drug labels and information packets was conducted with 576 people in the Boston metropolitan area. Results showed that: (1) 75% felt that it is important to read the label; (2) 71% felt the label warnings are sufficient; (3) 80% felt the labels were easy to understand; (4) 82% felt the dosage information was sufficient; and (5) 85% felt the dosage information was easy to understand. Changes advocated by the majority of respondents included larger print, improved warnings and ingredient information and graphic warning devices.
KW - Drugs, over-the-counter--labeling--patient information, consumer viewpoints;
KW - Labeling--drugs, over-the-counter--patient information, consumer viewpoints;
KW - Patient information--labeling--drugs, over-the-counter, consumer viewpoints;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0628&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1978-03951-001
AN - 1978-03951-001
AU - Hope, William
T1 - Consumers and PL 93-641.
JF - Journal of the National Association of Private Psychiatric Hospitals
JO - Journal of the National Association of Private Psychiatric Hospitals
JA - J Natl Assoc Priv Psychiatr Hosp
Y1 - 1976///Sum 1976
VL - 8
IS - 2
SP - 24
EP - 27
SN - 0027-8629
N1 - Accession Number: 1978-03951-001. PMID: 1026788 Partial author list: First Author & Affiliation: Hope, William; USDHEW Public Health Service, Region VII Office, Kansas City, MO. Release Date: 19780201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Behavior; Health Care Services; Laws. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 4. Issue Publication Date: Sum 1976.
AB - Describes how consumers can become involved in Health Systems Agencies provided for by the National Health Planning and Resources Development Act of 1974. Planning at the state level is also described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consumer involvement in Health Systems Agencies provided for by National Health Planning & Resources Development Act of 1974
KW - 1976
KW - Consumer Behavior
KW - Health Care Services
KW - Laws
KW - 1976
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Bremner, W. J.;
AU - Paulsen, C. A.;
T1 - Colchicine and testicular function in man
CT - Colchicine and testicular function in man
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/06/17/
VL - 294
IS - Jun 17
SP - 1384
EP - 1385
SN - 00284793
AD - U.S. Public Health Service Hospital, Box 3145, Seattle, Washington 98114
N1 - Accession Number: 13-4808; Language: English; Chemical Name: Colchicine--64-86-8; References: 10; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - The effect of colchicine (I) on testicular function was studied in 7 normal men. All subjects underwent 2 months of control observations. Three subjects then received I for 6 months, followed by a further 2 months of control observations. Four subjects received I for 3 to 4 months with no post-drug control observations. In all subjects, I was begun in a dosage of 0.6 mg/day given by mouth. It was increased over 2 weeks to a dosage of 2.4 mg/day. In the subjects treated for 6 months, this dosage was maintained for the full period of observation. Results showed that I administration caused no statistically significant changes in any of the variables measured when ingested for 3, 4 or 6 months.
KW - Colchicine--toxicity-;
KW - Toxicity--colchicine--studies, effects on testicular function, in normal male patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Flick, Donald F.
T1 - ANOTHER PLEA FOR TOLERANCE.
JO - BioScience
JF - BioScience
Y1 - 1976/07//
VL - 26
IS - 7
M3 - Letter
SP - 426
EP - 426
SN - 00063568
AB - A letter to the editor is presented in response to an editorial "A Plea for Tolerance and Courtesy," in the March 1976 issue.
KW - Letters to the editor
KW - Creative ability in science
N1 - Accession Number: 28050323; Flick, Donald F. 1; Affiliations: 1 : Health Sciences Coordinator Food and Drug Administration Washington, DC 20204; Source Info: Jul1976, Vol. 26 Issue 7, p426; Subject Term: Letters to the editor; Subject Term: Creative ability in science; Number of Pages: 1/3p; Document Type: Letter; Full Text Word Count: 569
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
TY - GEN
AU - Hopkins, H.;
T1 - Regulating vitamins and minerals
CT - Regulating vitamins and minerals
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/07/01/
VL - 10
IS - Jul-Aug
SP - 10
EP - 11
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-3063; Language: English; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: Henri Manasse
N2 - A new law passed by Congress regarding the proper role of the FDA regarding vitamins and minerals is discussed. This law states that the FDA should protect the consumer from harmful substances and false claims, but should not be concerned with restricting vitamin and mineral levels to those that the agency believes has nutritional benefit. It also cannot limit the kinds of and numbers of vitamin-mineral combinations offered.
KW - Laws--vitamins--and minerals, combinations, FDA limitations in regulating;
KW - Food and Drug Administration (U.S.)--laws--limitations, in regulating vitamin and mineral combinations;
KW - Vitamins--combination, minerals--laws, limitations on FDA regulations;
KW - Minerals--combination, vitamins--laws, limitations on FDA regulations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Strengthening drug manufacturing practices
CT - Strengthening drug manufacturing practices
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1976/07/01/
VL - 10
IS - Jul-Aug
SP - 12
EP - 14
SN - 03621332
AD - HFI-20, Food and Drug Administration, 5600 Fishers Ln., Rockville, Maryland 20852
N1 - Accession Number: 14-0604; Language: English; Chemical Name: Penicillin--1406-05-9; Journal Coden: FDACBH; Section Heading: Legislation, Laws and Regulations; Abstract Author: Henri Manasse
N2 - A discussion of the Good Manufacturing Practices regulations and the inclusion of drug expiration dating and controls for penicillin production is presented.
KW - Penicillin--manufacturing-;
KW - Good Manufacturing Practices--regulations--discussion;
KW - Regulations--Good Manufacturing Practices--discussion;
KW - Expiration dates--drugs--regulations, Good Manufacturing Practices;
KW - Manufacturing--penicillin--control, Good Manufacturing Practices;
KW - Control--penicillin--Good Manufacturing Practices;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0604&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hamilton, D. R.;
AU - Barnett, M.;
T1 - Radiopharmacy: challenge of an emerging specialty
CT - Radiopharmacy: challenge of an emerging specialty
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1976/07/01/
VL - 11
IS - Jul
SP - 364
EP - 365
SN - 00986909
AD - Bureau of Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland
N1 - Accession Number: 14-1890; Language: English; References: 3; Journal Coden: HOFOD9; Section Heading: Institutional Pharmacy Practice; Abstract Author: Douglas L. Thompson
N2 - The role of the radiopharmacist in the hospital field is discussed.
KW - Radiopharmaceuticals--services--role, radiopharmacists;
KW - Radiopharmacists--role--hospitals;
KW - Hospitals--radiopharmaceuticals--role, radiopharmacists;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-1890&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Graham, R. E.;
AU - Biehl, E. R.;
AU - Kenner, C. T.;
T1 - Effect of solvent on tetrazolium reaction
CT - Effect of solvent on tetrazolium reaction
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/07/01/
VL - 65
IS - Jul
SP - 1048
EP - 1053
SN - 00223549
AD - Food and Drug Administration, Dallas District, Dallas, Texas 75204
N1 - Accession Number: 14-0148; Language: English; References: 20; Journal Coden: JPMSAE; Section Heading: Pharmaceutics; Pharmaceutical Chemistry; Abstract Author: Paul R. Webster
N2 - The effects of various solvents and solvent dielectric constants on the color development of tetrazolium formazan formed with corticosteroids was studied. Color development was shown to be inversely proportional to the dielectric constant of the solvent medium and directly proportional to the hydrogen bonding capability of solvent mixtures having the same dielectric constant.
KW - Tetrazolium--colorimetry-;
KW - Colorimetry--tetrazolium--steroids, cortico-, effects of solvents and dielectric constants on color development;
KW - Dielectric constants--tetrazolium--effects, color development in colorimetric procedures;
KW - Solvents--effects--tetrazolium, color development in colorimetric procedures;
KW - Steroids, cortico---colorimetry--tetrazolium reactions, effects of solvents and dielectric constants on color development;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0148&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schneider, Edward L.
T1 - HUMAN AGING.
JO - BioScience
JF - BioScience
Y1 - 1976/08//
VL - 26
IS - 8
M3 - Book Review
SP - 507
EP - 507
SN - 00063568
AB - The article reviews the book "The Physiology and Pathology of Human Aging," edited by Ralph Goldman and Morris Rockstein.
KW - Aging
KW - Nonfiction
KW - Goldman, Ralph
KW - Rockstein, Morris
KW - Physiology & Pathology of Human Aging, The (Book)
N1 - Accession Number: 28049555; Schneider, Edward L. 1; Affiliations: 1 : Laboratory of Cellular & Comparative Physiology Gerontology Research Center, NIH National Institute on Aging HEW Public Health Service Bethesda & Baltimore City Hospitals Baltimore, MD 21224; Source Info: Aug1976, Vol. 26 Issue 8, p507; Subject Term: Aging; Subject Term: Nonfiction; Number of Pages: 1/3p; Document Type: Book Review; Full Text Word Count: 308
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=8gh&AN=28049555&site=ehost-live&scope=site
DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
TY - GEN
AU - McClane, T. R.;
AU - Martin, W. R.;
T1 - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
CT - Subjective and physiologic effects of morphine, pentobarbital, and meprobamate
JO - Clinical Pharmacology and Therapeutics (USA)
JF - Clinical Pharmacology and Therapeutics (USA)
Y1 - 1976/08/01/
VL - 20
IS - Aug
SP - 192
EP - 198
SN - 00099236
AD - National Institute on Drug Abuse, Div. of Research, Addiction Research Center, U.S. Dept. of HEW Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, P.O. Box 12390, Lexington, Kentucky 40511
N1 - Accession Number: 14-2346; Language: English; Chemical Name: Morphine--57-27-2 Meprobamate--57-53-4 Pentobarbital--76-74-4; Therapeutic Class: (28:16.08); AHFS Class: Tranquilizers meprobamate, comparison, morphine, pentobarbital (28:08); AHFS Class: Analgesics and antipyretics morphine, comparison, meprobamate, pentobarbital; References: 6; Journal Coden: CLPTAT; Human Indicator: Yes; Section Heading: Pharmacology; Drug Evaluations
N2 - Pentobarbital (I), morphine (II), and meprobamate (III) were studied in a group of 12 postaddict subjects to determine their effects on subjective states and postrotational nystagmus. I, 150 mg induced a degree of liking and an elevation of the morphine-benzedrine group (MBG) scale score equivalent to 24 mg of II. The effects of I and III on postrotational nystagmus were studied using electro-oculography. Both drugs increased the frequency and prolonged the duration of postrotational nystagmus in a dose related manner. III was about 1/15 as potent as I in enhancing postrotational nystagmus and producing signs of sedation.
KW - Morphine--comparison, meprobamate, pentobarbital-;
KW - Meprobamate--comparison, morphine, pentobarbital-;
KW - Pentobarbital--comparison, meprobamate, morphine-;
KW - Dosage--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW - Dosage--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, humans;
KW - Dosage--pentobarbital, comparison, meprobamate, morphine--effects, subjective, and postrotational nystagmus, humans;
KW - Tranquilizers--meprobamate, comparison, morphine, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
KW - Analgesics and antipyretics--morphine, comparison, meprobamate, pentobarbital--effects, subjective, and postrotational nystagmus, dosage, humans;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-2346&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1977-11109-001
AN - 1977-11109-001
AU - Chadwick, Gary L.
T1 - Psychiatric pharmacy residency and services.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 1976/08//
VL - 141
IS - 8
SP - 537
EP - 539
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
N1 - Accession Number: 1977-11109-001. PMID: 821013 Partial author list: First Author & Affiliation: Chadwick, Gary L.; Indian Health Service, W. W. Hastings Indian Hosp, Tahlequah, OK. Release Date: 19770501. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health; Community Mental Health Training; Mental Health Personnel; Mental Health Personnel Supply; Personnel. Classification: Professional Education & Training (3410); Community & Social Services (3373). Population: Human (10). Page Count: 3. Issue Publication Date: Aug, 1976.
AB - Advocates the use of pharmacists in a clinical role to meet the rising need for mental health professionals. Such a pharmacist would work closely with other clinical staff members in the planning and execution of a treatment regimen and in the follow-up of the patient. As a member of a mental health team, the pharmacist would provide a complete history of prescription and nonprescription drugs used by patients currently and in the past. Fully trained psychiatric pharmacists would also be able to select the best possible drug for a specific patient. The role of the pharmacist in special programs is discussed, and his functions in a mental retardation center are listed. The need for training programs which prepare the pharmacist to work with other members of the mental health team and to have a useful area of expert functioning is discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - proposed clinical role for pharmacists & mental health team membership & functions & training
KW - 1976
KW - Community Mental Health
KW - Community Mental Health Training
KW - Mental Health Personnel
KW - Mental Health Personnel Supply
KW - Personnel
KW - 1976
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1977-11109-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Gregory, J. M.;
AU - Knapp, D. E.;
T1 - State of the art of drug usage review
CT - State of the art of drug usage review
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1976/09/01/
VL - 33
IS - Sep
SP - 925
EP - 928
SN - 00029289
AD - Drug Use Analysis Branch (HFD-216), Food and Drug Administration, Rockville, Maryland 20852
N1 - Accession Number: 13-5951; Language: English; Journal Coden: AJHPA9; Section Heading: Methodology
N2 - Drug usage review studies in 16 medical, allied health and pharmaceutical journals from 1970 to 1975 are analyzed. The studies cited included systematic data collection of prescription orders and an evaluation of these orders on at least one of the following: daily dose, length of therapy of quantity dispensed, or appropriateness of the drug itself. Gaps in both content and methodology of the drug usage review programs were discovered, and methods for improving future studies are discussed.
KW - Utilization review--studies--discussion;
KW - Literature--utilization review--studies, discussion;
KW - Methodology--utilization review--studies, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=13-5951&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Shepherd, R. E.;
T1 - FDA inspections of large volume and small volume parenteral manufacturers
CT - FDA inspections of large volume and small volume parenteral manufacturers
JO - Bull. Parenteral Drug Assoc.
JF - Bull. Parenteral Drug Assoc.
Y1 - 1976/09/01/
VL - 30
IS - Sep-Oct
SP - 209
EP - 213
AD - Food and Drug Administration, Rockville, Maryland
N1 - Accession Number: 14-1197; Language: English; Journal Coden: BUYRAI; Section Heading: Legislation, Laws and Regulations
N2 - A systems evaluation approach to an inspection, which includes the basic concepts of Good Manufacturing Practices, scientific method, and common sense is described. This approach may be used for the evaluation of production, quality control, and engineering operations involved in the production of large volume and small volume parenterals. During an investigation a set of basic criteria relating to the quality of the finished product is used to evaluate each system and its effect on this quality.
KW - Food and Drug Administration (U.S.)--injections--regulations, inspections, quality control and GMP;
KW - Control, quality--injections--inspections, FDA, regulations, GMP;
KW - Regulations--injections--inspections, FDA, quality control and GMP;
KW - Injections--regulations--inspections, FDA, quality control and GMP;
KW - Good Manufacturing Practices--injections--regulations, FDA, inspections, quality control;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-1197&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Coe, J.E.
AU - Leong, D.
AU - Portis, J.L.
AU - Thomas, L.A.
T1 - Immune response in the garter snake (Thamnophis ordinoidesJournal of Nursing Administration (1976) March-April. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Advanced Nursing is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - NURSING research
KW - ACTION research in nursing
KW - CARE of the sick
KW - FORUMS (Discussion & debate)
KW - LOUISIANA
KW - UNITED States
N1 - Accession Number: 14276639; Gortner, Susan R. 1; Bloch, Doris 1; Phillips, Thomas P. 1; Source Information: Nov76, Vol. 1 Issue 6, p507; Subject: MEDICAL care; Subject: NURSING research; Subject: ACTION research in nursing; Subject: CARE of the sick; Subject: FORUMS (Discussion & debate); Geographic Terms: LOUISIANA; UNITED States; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1365-2648.ep14276639
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=14276639&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Stross, J. K.;
AU - Shasby, M.;
AU - Harlan, W. R.;
T1 - Epidemic of mysterious cardiopulmonary arrests
CT - Epidemic of mysterious cardiopulmonary arrests
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/11/11/
VL - 295
IS - Nov 11
SP - 1107
EP - 1110
SN - 00284793
AD - Reprints: Towsley Center for Continuing Medical Education, Univ. of Michigan Medical Center, Ann Arbor, Michigan 48109
AD - Dept. of Postgraduate Medicine and Health Professions and Internal Medicine, Univ. of Michigan Medical School, Ann Arbor; and the Bureau of Epidemiology, Public Health Service, U.S. Dept. of Health, Education, and Welfare
N1 - Accession Number: 14-1520; Language: English; Therapeutic Class: (12:20); AHFS Class: Skeletal muscle relaxants pancuronium; References: 7; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Abstract Author: Joan Lentine
N2 - The epidemiologic investigation which was undertaken following a striking increase in the incidence of cardiopulmonary arrests at the Ann Arbor, Michigan Veterans Administration hospital during July and August of 1975 is discussed. After the criminal investigation was completed, indictments were handed down against 2 nurses working in the intensive care unit. Results of the investigation revealed that pancuronium bromide was the offending agent, and had been placed in IV solutions, resulting in the cardiopulmonary arrests.
KW - Pancuronium--crime-;
KW - Crime--hospitals--pancuronium, cardiac arrests in patients following willful administration by nurses;
KW - Hospitals--crime--pancuronium, cardiac arrests in patients following willful administration by nurses;
KW - Nurses--crime--hospitals, cardiopulmonary arrests in patients following willful administration of pancuronium;
KW - Skeletal muscle relaxants--pancuronium--crime, hospitals, cardiopulmonary arrests in patients following willful administration by nurses;
KW - Toxicity--pancuronium--crime, cardiac arrests in patients following willful administration by nurses;
KW - Poisoning--pancuronium--crime, cardiac arrests in patients following willful administration by nurses;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-1520&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cates, W.;
AU - Ory, H. W.;
AU - Rochat, R. W.;
AU - Tyler, C. W.;
T1 - Intrauterine device and deaths from spontaneous abortion
CT - Intrauterine device and deaths from spontaneous abortion
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/11/18/
VL - 295
IS - Nov 18
SP - 1155
EP - 1159
SN - 00284793
AD - Family Planning Evaluation Div., Bureau of Epidemiology, Center for Disease Control, Public Health Service, U.S. Dept. of Health, Education and Welfare, Atlanta, Georgia 30333
N1 - Accession Number: 14-0981; Language: English; References: 22; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity
N2 - In this report, deaths from spontaneous abortion in the U.S. between 1972 and 1974, with special attention to the intrauterine device the (IUD) as a risk factor were analyzed. Women dying from spontaneous abortions with a device in place were more likely to be young, white and married than those not wearing a device. Risk of death from spontaneous abortion was over 50 times greater for women who continued their pregnancy with a device in place than for those who did not. The Dalkon shield carried an increased risk of death, as compared to other devices, even after rates were adjusted for duration of use. However, pregnant women with either a loop or a coil in place also had a higher risk of dying from spontaneous abortion than those without any device. The results support the clinical recommendation that any device should be removed when pregnancy is first diagnosed.
KW - Contraceptives, intrauterine devices--toxicity--studies, spontaneous abortions, fatal, patients;
KW - Toxicity--contraceptives, intrauterine devices--studies, spontaneous abortions, fatal, patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-0981&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Nony, C. R.;
AU - Bowman, M. C.;
AU - Holder, C. L.;
AU - Young, J. F.;
AU - Oller, W. L.;
T1 - Trace analysis of 2,4,5-trichlorophenoxyacetic acid, its glycineamide, and their alkaline hydrolyzable conjugates in mouse blood, urine, and feces
CT - Trace analysis of 2,4,5-trichlorophenoxyacetic acid, its glycineamide, and their alkaline hydrolyzable conjugates in mouse blood, urine, and feces
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1976/12/01/
VL - 65
IS - Dec
SP - 1810
EP - 1816
SN - 00223549
AD - Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arizona 72079
N1 - Accession Number: 14-2390; Language: English; References: 9; Journal Coden: JPMSAE; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis; Abstract Author: Paul R. Webster
N2 - Procedures to determine traces of 2,4,5-trichlorophenoxyacetic acid and derivatives via electron capture GLC and comparison of the results with radioimmunoassay in mice are described. Radioassay results from blood, urine and feces generally correlated well with electron capture GLC. Losses during both procedures were found to be negligible.
KW - 2,4,5-Trichlorophenoxyacetic acid--and derivatives-;
KW - Herbicides--2,4,5-trichlorophenoxyacetic acid--and derivatives, blood levels, urinary and fecal excretion, electron capture GLC, mice;
KW - Chromatography, gas--2,4,5-trichlorophenoxyacetic acid--and derivatives, electron capture, blood levels, urinary and fecal excretion, mice;
KW - Blood levels--2,4,5-trichlorophenoxyacetic acid--and derivatives, electron capture GLC, mice;
KW - Excretion--2,4,5-trichlorophenoxyacetic acid--and derivatives, urinary and fecal, mice;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-2390&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ascherl, G. F.;
AU - Fulkerson, L. L.;
AU - Stein, E.;
T1 - Tolbutamide induced diffuse lung disease: case report
CT - Tolbutamide induced diffuse lung disease: case report
JO - Mil. Med.
JF - Mil. Med.
Y1 - 1976/12/01/
VL - 141
IS - Dec
SP - 851
EP - 852
AD - Dept. of Radiology and Med., U. S. Public Health Service Hosp., Staten Island, NY 10304
N1 - Accession Number: 15-2287; Language: English; Chemical Name: Tolbutamide--64-77-7; Therapeutic Class: (68:20); AHFS Class: Antidiabetic agents tolbutamide; References: 4; Journal Coden: MMEDA9; Human Indicator: Yes; Section Heading: Adverse Drug Reactions
N2 - A 59-yr-old-man with mild diabetes mellitus was found to have diffuse pulmonary densities after 18 months of therapy with tolbutamide (I), one g/day. Discontinuation of I resulted in an almost complete regression of findings within 3 weeks.
KW - Tolbutamide--adverse reactions-;
KW - Drugs, adverse reactions--tolbutamide--lung disease, diffuse, chronic use, patient;
KW - Antidiabetic agents--tolbutamide--lung disease, diffuse, chronic use, patient;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=15-2287&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Jacobson, R. R.;
AU - Hastings, R. C.;
T1 - Rifampin resistant leprosy
CT - Rifampin resistant leprosy
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1976/12/11/
VL - 2
IS - Dec 11
SP - 1304
EP - 1305
SN - 00237507
AD - U. S. Public Health Service Hospital, Carville, Louisiana 70721
N1 - Accession Number: 14-1995; Language: English; Chemical Name: Rifampin--13292-46-1; Therapeutic Class: (8:00); AHFS Class: Antileprotic agents rifampin; References: 7; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Joan Lentine
N2 - Presented is the case of a 49-yr-old male with sulfone-resistant lepromatous leprosy who experienced clinical and bacteriological relapse while on rifampin monotherapy.
KW - Rifampin--leprosy-;
KW - Antileprotic agents--rifampin--therapy, lepromatous sulfone resistant, relapse, patient;
KW - Sulfones--resistance--leprosy, lepromatous, rifampin therapy, patient;
KW - Resistance--sulfones--leprosy, lepromatous, rifampin therapy, patient;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-1995&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Grimes, D. A.;
AU - Cates, W.;
T1 - Deaths from paracervical anesthesia used for first trimester abortion, 1972-1975
CT - Deaths from paracervical anesthesia used for first trimester abortion, 1972-1975
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1976/12/16/
VL - 295
IS - Dec 16
SP - 1397
EP - 1399
SN - 00284793
AD - Family Planning Evaluation Div., Bureau of Epidemiology, Center for Disease Control, Public Health Service, U.S. DHEW, Atlanta, Georgia 30333
N1 - Accession Number: 14-2223; Language: English; Chemical Name: Lidocaine--137-58-6 Mepivacaine--96-88-8; Therapeutic Class: (72:00); AHFS Class: Anesthetics, local lidocaine (72:00); AHFS Class: Anesthetics, local mepivacaine; References: 20; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Joan Lentine
N2 - This report describes 3 deaths from paracervical anesthesia (lidocaine and mepivacaine) used for first trimester abortions. Toxic doses of lidocaine, substantiated by post-mortem blood levels of 5 and 9 mcg/ml, probably led to 2 deaths; and intolerance to or inadvertent IV administration of mepivacaine probably caused the third. Administration of an appropriate dose of local anesthetic appears to be the single most important factor in preventing catastrophic reactions.
KW - Lidocaine--toxicity-;
KW - Mepivacaine--toxicity-;
KW - Toxicity--lidocaine--fatal, first trimester abortion patients;
KW - Toxicity--mepivacaine--fatal, first trimester abortion patients;
KW - Anesthetics, local--lidocaine--toxicity, fatal, first trimester abortion patients;
KW - Anesthetics, local--mepivacaine--toxicity, fatal, first trimester abortion patients;
KW - Dosage--lidocaine--high, toxicity, fatal, first trimester abortion patients;
KW - Dosage--mepivacaine--high, toxicity, fatal, first trimester abortion patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-2223&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Knoben, J. E.;
T1 - Role of drug information in PSRO review
CT - Role of drug information in PSRO review
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1977/01/01/
VL - 11
IS - Jan-Mar
SP - 43
EP - 46
SN - 00928615
AD - Div. of Quality and Standards, U.S. Public Health Service, San Francisco, California
N1 - Accession Number: 14-5498; Language: English; References: 4; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: James A. Starner
N2 - Adequate and readily available drug information is seen as essential to conducting a proper medical care evaluation as part of the PSRO review system.
KW - Professional Standards Review Organizations--drug information--role, evaluations, discussion;
KW - Drug information--Professional Standards Review Organizations--role, evaluations, discussion;
KW - Methodology--Professional Standards Review Organizations--drug information, role, evaluations, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-5498&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Herrick, S S
AU - Konvicka, A.j.
AU - Lawrence, L.r.
T1 - Information systems as utilized by the national center for toxicological research
JO - Drug Information Journal 11, 104-108 (1977 April-june)
JF - Drug Information Journal 11, 104-108 (1977 April-june)
Y1 - 1977///
M3 - Book Chapter
AB - An integrated toxicology information system is described including data bases and component systems.
N1 - Accession Number: ISTA1301151; Herrick, S S 1; Konvicka, A.j. 1; Lawrence, L.r.; Affiliations: 1 : National Center For Toxicological Research, Jefferson, Arkansas.; Source Info: 1977; Note: Update Code: 1300; Document Type: Book Chapter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1301151&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Rogers, H Patricia
T1 - Fundamental classification categories for the human information processing system: a model derived from constraints of human motivation and perception
JO - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
JF - In Fry, Bernard M., Comp.; Shepherd, Clayton A., Comp. Information Management In The 1980's. Proceedings Of The Asis 40th Annual Meeting. Chicago, September 26 To October 1, 1977. Volume 14. Part I. Abstracts Of Papers. Part Ii. Full Papers. 1977. Knowled
Y1 - 1977///
M3 - Book
AB - A fundamental classification system for human information processing has been discovered. The system is derived from existing orderly relationships among fundamental capacities of human beings for perception and motivated response. Ten basic categories, which encompass all humanly useful data, information, and knowledge, and which relate analogously to those underlying capacities, have been isolated (listed). A visual representation of the system includes universally recognizable colors-associable with the different energy levels of the categories; and emotionally and intellectually satisfying; and presented in an order which corresponds to the relationships among the categories themselves. It is suggested that the basic color system be used in teaching the classification, in managing records of all types, and in organizing records for public use. Examples are provided that relate the basic categories to language concepts. Some trends in research and technology whose results support the model are listed.
N1 - Accession Number: ISTA1301442; Rogers, H Patricia 1; Affiliations: 1 : Library, Center For Disease Control, Public Health Service, Us Department Of Health, Education, & Welfare, Atlanta, Georgia.; Source Info: 1977; Note: Update Code: 1300; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Brower, J. F.;
T1 - Collaborative study of a semiautomated method for the analysis of prednisolone and prednisone tablets
CT - Collaborative study of a semiautomated method for the analysis of prednisolone and prednisone tablets
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/01/01/
VL - 60
IS - Jan
SP - 27
EP - 31
AD - National Center for Drug Analysis, Food and Drug Administration, 1114 Market St., St. Louis, Missouri 63101
N1 - Accession Number: 14-2694; Language: English; Chemical Name: Prednisolone--50-24-8 Prednisone--53-03-2; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A semiautomated colorimetric method for the determination of prednisolone (I) and prednisone (II) was collaboratively studied. An alcoholic solution of the drug is extracted with chloroform and the extract is reacted with tetramethylammonium hydroxide and blue tetrazolium; the absorbance of the resulting color is read at 525 nm. Collaborators were supplied with 4 composites of tablets of different dosage levels, 2 containing I and 2 containing II. Results agreed with those obtained using the USP total steroid assay method. The coefficients of variation of the individual collaborator's results for I and II ranged from 0.54 to 2.38 and from 0.34 to 2.19%, respectively.
KW - Prednisolone--colorimetry-;
KW - Prednisone--colorimetry-;
KW - Colorimetry--prednisolone--semiautomated, tablets;
KW - Colorimetry--prednisone--semiautomated, tablets;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Venable, R. M.;
AU - Doyle, T. D.;
T1 - Specific solvation of ion pairs: examination of anion solvent complexes by spectral methods
CT - Specific solvation of ion pairs: examination of anion solvent complexes by spectral methods
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/01/01/
VL - 60
IS - Jan
SP - 52
EP - 55
AD - Div. of Drug Chemistry, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 14-2702; Language: English; Chemical Name: Dextromethorphan--125-71-3 Chloroform--67-66-3; References: 15; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - IR and NMR spectroscopy experiments support the theory that chloroform associates by hydrogen bonding to the halide ion of ion pairs. IR spectra of dextromethorphan HBr in chloroform showed the same effect. This proved a definitive, albeit qualitative, demonstration of the controversial concept of specific solvation of ion pairs, central to an understanding of solvent effects in analysis of drugs by ion pair partition. Quantitative implications are less clear. Indications that several molecules of chloroform may be involved in complexation are presented and discussed. Results of similar experiments with methylene chloride are inconclusive.
KW - Dextromethorphan--ion pairs-;
KW - Chloroform--ion pairs-;
KW - Ion pairs--solvation--specific;
KW - Bonds--hydrogen--halides, ions, ion pairs;
KW - Solvents--anions--complexes, specific solvation of ion pairs;
KW - Halides--ions--bonds, hydrogen, to chloroform;
KW - Complexes--chloroform and halides--bonds, hydrogen, ion pairs;
KW - Complexes--halides and chloroform--bonds, hydrogen, ion pairs;
KW - Anions--solvents--complexes, specific solvation of ion pairs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Singh, M.;
T1 - High pressure liquid chromatographic determination of uncombined intermediates in FD&C Red No. 2 (amaranth)
CT - High pressure liquid chromatographic determination of uncombined intermediates in FD&C Red No. 2 (amaranth)
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/01/01/
VL - 60
IS - Jan
SP - 173
EP - 175
AD - Div. of Color Technology, Food and Drug Administration, Washington, D.C. 20204
N1 - Accession Number: 14-2696; Language: English; Trade Name: FD&C Red No. 2; Generic Name: Amaranth; Chemical Name: Amaranth--915-67-3; Journal Coden: JANCA2; Section Heading: Drug Analysis
KW - Amaranth--chromatography, liquid-;
KW - Dyes--amaranth--chromatography, liquid, high pressure, uncombined intermediates;
KW - Chromatography, liquid--amaranth--high pressure, uncombined intermediates;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1979-01643-001
AN - 1979-01643-001
AU - Ryder, Claire F.
AU - Ross, Diane M.
T1 - Terminal care: Issues and alternatives.
JF - Health Services Reports
JO - Health Services Reports
JA - Health Serv Rep
Y1 - 1977/01//Jan-Feb, 1977
VL - 92
IS - 1
SP - 20
EP - 29
CY - US
PB - U. S. Public Health Service
SN - 0090-2918
N1 - Accession Number: 1979-01643-001. PMID: 64990 Other Journal Title: H.S.M.H.A. Health Reports; Public Health Reports. Partial author list: First Author & Affiliation: Ryder, Claire F.; Public Health Service, Ofc of Long Term Care, Rockville, MD. Other Publishers: Association of Schools of Public Health; Elsevier Science; Oxford University Press; U.S. Dept. of Health, Education, and Welfare, Health Services and Mental Health Administration; U.S. Marine Hospital Service. Release Date: 19790101. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Coping Behavior; Death Attitudes; Terminally Ill Patients; Treatment. Classification: Behavioral & Psychological Treatment of Physical Illness (3361). Population: Human (10). Page Count: 10. Issue Publication Date: Jan-Feb, 1977.
AB - Discusses attitudes toward, patterns of coping with, and approaches to the treatment of terminally ill patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attitudes toward & patterns of coping with & approaches to treatment of terminally ill patients
KW - 1977
KW - Coping Behavior
KW - Death Attitudes
KW - Terminally Ill Patients
KW - Treatment
KW - 1977
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1978-00491-001
AN - 1978-00491-001
AU - Myers, Ronald E.
T1 - Production of fetal asphyxia by maternal psychological stress.
JF - Pavlovian Journal of Biological Science
JO - Pavlovian Journal of Biological Science
JA - Integr Physiol Behav Sci
Y1 - 1977/01//Jan-Mar, 1977
VL - 12
IS - 1
SP - 51
EP - 62
CY - US
PB - Transaction Publishers
SN - 1053-881X
N1 - Accession Number: 1978-00491-001. PMID: 404618 Other Journal Title: Conditional Reflex; Integrative Physiological & Behavioral Science; Integrative Psychological & Behavioral Science. Partial author list: First Author & Affiliation: Myers, Ronald E.; USDHEW, Public Health Service, Bethesda, MD. Other Publishers: Springer. Release Date: 19780101. Correction Date: 20151026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Anoxia; Biochemistry; Fetus; Prenatal Development; Psychological Stress. Minor Descriptor: Blood; Monkeys; Pregnancy. Classification: Physiological Processes (2540). Population: Animal (20). Page Count: 12. Issue Publication Date: Jan-Mar, 1977.
AB - In 8 anesthetized pregnant rhesus monkeys, catheters were placed into the maternal and the fetal femoral ateries for the continuous recording of blood pressure, heart rate, and intrauterine pressures. As the mothers awakened, the fetuses invariably showed the development of fetal asphyxia. Studies while the mothers were fully awake showed the repeated and regular development of episodes of heightened fetal asphyxia produced by stressful stimulation of the mothers. Episodes of maternal psychological stress led to changes in both fetal vital signs and blood chemical findings. These alterations in fetal state regularly followed the onset of the episodes of psychological stress by 50 sec. These changes also usually remitted 50 sec following the termination of stress. Results demonstrate a direct and unequivocal relationship between maternal psychological stress and fetal asphyxia. It is assumed that maternal stress produces impairments in the circulation to the uterus through an increased sympathetic nervous system activity and a shunting of the maternal blood-flow from the abdominal viscera to other organs as occurs in the fight-or-flight reaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal psychological stress during pregnancy
KW - fetal blood chemistry & asphyxia
KW - monkeys
KW - 1977
KW - Anoxia
KW - Biochemistry
KW - Fetus
KW - Prenatal Development
KW - Psychological Stress
KW - Blood
KW - Monkeys
KW - Pregnancy
KW - 1977
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1979-04256-001
AN - 1979-04256-001
AU - Rose, John B.
T1 - Tricyclic antidepressant toxicity.
JF - Clinical Toxicology
JO - Clinical Toxicology
Y1 - 1977///
VL - 11
IS - 4
SP - 391
EP - 402
CY - US
PB - Marcel Dekker, Inc.
N1 - Accession Number: 1979-04256-001. PMID: 589952 Partial author list: First Author & Affiliation: Rose, John B.; US Public Health Service National Health Service Corps, Yuba Feather Health Ctr, Brownsville, CA. Release Date: 19790201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Drug Overdoses; Drug Therapy; Toxic Disorders; Toxicity. Minor Descriptor: Treatment. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 12. Issue Publication Date: 1977.
AB - Reviews data on tricyclic antidepressant (TCAD) toxic reactions, and specifically cardiac toxicity, as well as TCAD-related deaths. The chemistry and efficacy of TCAD compounds and the variations between them are described, and treatment for TCAD overdose is outlined. (20 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tricyclic antidepressant toxic reactions
KW - 1977
KW - Antidepressant Drugs
KW - Drug Overdoses
KW - Drug Therapy
KW - Toxic Disorders
KW - Toxicity
KW - Treatment
KW - 1977
DO - 10.3109/15563657708988202
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1979-04256-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - ALBRECHT, PAUL
AU - BURNSTEIN, THEODORE
AU - KLUTCH, MICHAEL J.
AU - HICKS, JOHN T.
AU - ENNIS, FRANCIS A.
T1 - Subacute Sclerosing Panencephalitis: Experimental Infection in Primates.
JO - Science
JF - Science
Y1 - 1977/01/07/
VL - 195
IS - 4273
M3 - Article
SP - 64
EP - 66
SN - 00368075
AB - Measles virus isolated from the brain of a 12-year-old boy with subacute sclerosing panencephalitis caused a chronic, progressive encephalitis in experimentally infected rhesus monkeys. The infection was eventually fatal in spite of preexisting measles immunity and a vigorous secondary antibody response in serum and cerebrospinal fluid of the infected animals. The findings provide a basis for studies into the pathogenesis and possible treatment of the human disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361392; ALBRECHT, PAUL 1; BURNSTEIN, THEODORE 2; KLUTCH, MICHAEL J. 3; HICKS, JOHN T. 3; ENNIS, FRANCIS A. 3; Affiliations: 1: Bureau of Biologics, Division of Virology, Food and Drug Administration, Bethesda, Maryland 20014; 2: Department of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907; 3: Bureau of Biologics, Division of Virology, Food and Drug Administration; Issue Info: 1/ 7/1977, Vol. 195 Issue 4273, p64; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MOORE JR., ROSCOE M.
AU - WOOLF, BARBARA S.
AU - STEIN, HARVEY P.
AU - THOMAS, A. W.
AU - FINKLEA, JOHN F.
T1 - Metabolic Precursors of a Known Human Carcinogen.
JO - Science
JF - Science
Y1 - 1977/01/28/
VL - 195
IS - 4276
M3 - Article
SP - 344
EP - 344
SN - 00368075
N1 - Accession Number: 85218292; MOORE JR., ROSCOE M. 1; WOOLF, BARBARA S. 1; STEIN, HARVEY P. 1; THOMAS, A. W. 1; FINKLEA, JOHN F. 1; Affiliations: 1: National Institute for Occupational Safety and Health, 5600 Fishers Lane, Rockville, Maryland 20857; Issue Info: 1/28/1977, Vol. 195 Issue 4276, p344; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Martin, R. J.;
AU - Michals, E. L.;
AU - Voth, M. R.;
T1 - Cyclophosphamide induced remission in Weber-Christian disease: case report
CT - Cyclophosphamide induced remission in Weber-Christian disease: case report
JO - Mil. Med.
JF - Mil. Med.
Y1 - 1977/02/01/
VL - 142
IS - Feb
SP - 158
EP - 160
AD - Dept. of Med., US Public Health Service Hosp., 210 State St., New Orleans, LA 70118
N1 - Accession Number: 15-1796; Language: English; Chemical Name: Cyclophosphamide--6055-19-2; Therapeutic Class: (92:00); AHFS Class: Immunosuppressive agents cyclophosphamide; References: 9; Journal Coden: MMEDA9; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A remission was induced in a 40-yr-old male with nodular nonsuppurative panniculitis (Weber-Christian disease) by treatment with cyclophosphamide (I), 1.5 mg/kg/day for 18 days. Several weeks later the patient developed colitis, and I treatment was discontinued. The patient had an exacerbation of the disease and I was reinstituted immediately, 75 mg/day and within 5 days another remission was produced. These remissions after I treatment suggest I was the cause of the improvement.
KW - Cyclophosphamide--therapy-;
KW - Toxicity--cyclophosphamide--colitis, nodular nonsuppurative, panniculitis, patient;
KW - Immunosuppressive agents--cyclophosphamide--panniculitis, nodular nonsuppurative, toxicity, patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1977-25305-001
AN - 1977-25305-001
AU - Kroll, Howard W.
AU - Moren, Deborah K.
T1 - Effect of appearance on requests for help in libraries.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1977/02//
VL - 40
IS - 1
SP - 129
EP - 130
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1977-25305-001. Partial author list: First Author & Affiliation: Kroll, Howard W.; Public Health Service, Alcohol, Drug Abuse, & Mental Health Administration, Philadelphia, PA. Other Publishers: Sage Publications. Release Date: 19770901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Assistance (Social Behavior); Clothing; Compliance; Educational Personnel; School Libraries. Classification: Social Psychology (3000). Population: Human (10). Page Count: 2. Issue Publication Date: Feb, 1977.
AB - Librarians in 8 public libraries provided comparable help to a college-age female when she was dressed as a deviant and when she was dressed as a college student. Possible reasons for these data (the Fisher exact probability test was used) are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - college female's type of attire
KW - helpfulness in responding to requests for assistance
KW - librarians
KW - 1977
KW - Assistance (Social Behavior)
KW - Clothing
KW - Compliance
KW - Educational Personnel
KW - School Libraries
KW - 1977
DO - 10.2466/pr0.1977.40.1.129
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1977-25305-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1978-05874-001
AN - 1978-05874-001
AU - Lindblad, Richard A.
T1 - Self-concept of White, middle socioeconomic status addicts: A controlled study.
JF - International Journal of the Addictions
JO - International Journal of the Addictions
JA - Int J Addict
Y1 - 1977/02//
VL - 12
IS - 1
SP - 137
EP - 151
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-773X
N1 - Accession Number: 1978-05874-001. PMID: 863557 Other Journal Title: Substance Use & Misuse. Partial author list: First Author & Affiliation: Lindblad, Richard A.; USDHEW Public Health Service, National Inst on Drug Abuse, Rockville, MD. Other Publishers: Informa Healthcare. Release Date: 19780301. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Drug Usage; Personality Development; Self-Concept; Whites. Minor Descriptor: Middle Class. Classification: Behavior Disorders & Antisocial Behavior (3230); Substance Abuse & Addiction (3233). Population: Human (10). Page Count: 15. Issue Publication Date: Feb, 1977.
AB - Conducted a controlled study of 70 White, middle socioeconomic status (WMSES) addicts and 70 WMSES nonaddicts to investigate commonalities in the developmental patterns of narcotic addiction and negative self-attitudes. Ss were given an instrument designed by the author that included some questions from the work of W. Mandell and Z. Amsel (1973) and the Tennessee Self-Concept Scale. The hypothesis that measures of self-attitudes would distinguish addicts from nonaddicts was confirmed with highly significant differences. The hypothesis that antecedent conditions purported to result in positive self-attitudes would distinguish addicts from controls was also supported. Developmental conditions posited as indices of early self-attitudes further discriminated the 2 groups. A self-reported profile of the WMSES addict was compiled describing drug-use patterns and childhood situations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developmental patterns of narcotic addiction & self attitudes
KW - White middle socioeconomic status addicts vs nonaddicts
KW - 1977
KW - Drug Addiction
KW - Drug Usage
KW - Personality Development
KW - Self-Concept
KW - Whites
KW - Middle Class
KW - 1977
DO - 10.3109/10826087709027214
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1978-05874-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - MCENROE, WILLIAM D.
AU - HEALY, GEORGE R.
AU - SPIELMAN, ANDREW
T1 - Human Babesiosis.
JO - Science
JF - Science
Y1 - 1977/02/04/
VL - 195
IS - 4277
M3 - Article
SP - 506
EP - 507
SN - 00368075
N1 - Accession Number: 85218368; MCENROE, WILLIAM D. 1; HEALY, GEORGE R. 2; SPIELMAN, ANDREW 3; Affiliations: 1: Suburban Experimental Station, University of Massachusetts, Amherst, Waltham 02154; 2: Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333; 3: Department of Tropical Public Health, Harvard University School of Public Health, Boston, Massachusetts 02115; Issue Info: 2/ 4/1977, Vol. 195 Issue 4277, p506; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hsu, C. C. S.
AU - Marti, G. E.
AU - Mittal, K. K.
T1 - Antisera against leukaemia-associated antigens on human lymphocytes.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/03//
VL - 27
IS - 3
M3 - Article
SP - 487
EP - 496
SN - 00099104
AB - Antisera were raised in rabbits against leukaemic lymphosarcoma (LSL) cells which carried surface markers of both thymus-derived T lymphocytes (T cells) and bone marrow-derived B lymphocytes (B cells). After absorption with leucocytes, erythrocytes and serum proteins from normal individuals, the antisera demonstrated significant complement-dependent cytotoxicity against leukaemic cells from patients with acute lymphoblastic leukaemia (ALL) (9/11), LSL (7/9) and chronic lymphocytic leukaemia (CLL) (9/12), with an antibody titre of 1:64 or greater. The antisera did not react with: (a) blood lymphocytes from clinically healthy individuals (0/23), patients with non-lymphoproliferative disorders (0/8) and normal umbilical cords (0/3), (h) normal lymphocytes stimulated by pokeweed mitogen (0/7), allogeneic lymphocytes (0/3), fetuin (0/1), purified protein derivative (PPD) (0/2), and candida antigen (0/1); (c) normal marrow cells (0/3), (d) normal thymocytes (0/2) and (e) leukaemic cells from patients with acute mycloblastic (AML) (0/10) and chronic granulocytic leukaemia (CGL) (0/3), However, the antisera did react with lymphoblastoid cells from continuous B-cell lines derived from an AML patient and from a non-leukaemic individual and, to a lesser extent, with lymphocytes from patients with infectious mononucleosis. The antisera also reacted with lymphocytes from chronically infected tonsils. Cytotoxicity of the antisera against lymphoblastoid and tonsillar cells was inhibited by ALL and CLL cell-lysates; and, conversely, cytotoxicity against ALL cells was inhibited by the lymphoblastoid cell extract. In contrast, a cell lysate or extract from normal lymphocytes did not inhibit cytotoxicity toward lymphoblastoid, tonsillar or ALL cells. Cytotoxicity of the antisera was neutralized by a goat anti-rabbit IgG (GAR IgG). These results suggest that the antisera contained antibodies reactive with antigens possibly common to neoplastic lymphocytes, tonsillar cells, lymphoblastoid cells and some blood lymphocytes from patients with infectious mononucleosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE serums
KW - ANTIGENS
KW - LYMPHOCYTES
KW - RABBITS
KW - HODGKIN'S disease
KW - PROTEINS
N1 - Accession Number: 15945769; Hsu, C. C. S. 1,2; Marti, G. E. 1,2; Mittal, K. K. 1,2; Source Information: Mar1977, Vol. 27 Issue 3, p487; Subject: IMMUNE serums; Subject: ANTIGENS; Subject: LYMPHOCYTES; Subject: RABBITS; Subject: HODGKIN'S disease; Subject: PROTEINS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Fésüs, L.
AU - Csaba, B.
AU - Muszbek, L.
T1 - Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/03//
VL - 27
IS - 3
M3 - Article
SP - 512
EP - 515
SN - 00099104
AB - Platelet-activating factor (PAF) generated by an IgE-mediated reaction in the peritoneal cavity of rats was partially purified by adsorption to diatomaceous earth. It aggregated rat platelets and, as a consequence, activated Hageman factor in in vitro, as well as in in vivo, conditions. The haemostatic alterations induced by PAF showed similarity to those observed in the early phase of rat anaphylaxis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelets
KW - RATS
KW - ADSORPTION
KW - ANAPHYLAXIS
KW - DIATOMACEOUS earth
KW - PLATELET activating factor
N1 - Accession Number: 15946303; Fésüs, L. 1; Csaba, B. 1; Muszbek, L. 2,3; Source Information: Mar1977, Vol. 27 Issue 3, p512; Subject: BLOOD platelets; Subject: RATS; Subject: ADSORPTION; Subject: ANAPHYLAXIS; Subject: DIATOMACEOUS earth; Subject: PLATELET activating factor; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Helton, E. D.;
AU - Goldzieher, J. W.;
T1 - Pharmacokinetics of ethinyl estrogens. A review
CT - Pharmacokinetics of ethinyl estrogens. A review
JO - Contraception (USA)
JF - Contraception (USA)
Y1 - 1977/03/01/
VL - 15
IS - Mar
SP - 255
EP - 284
SN - 00107824
AD - National Center for Toxicological Research, Jefferson, Arkansas 72079
N1 - Accession Number: 14-5687; Language: English; Chemical Name: Ethinyl estradiol--57-63-6 Mestranol--72-33-3; References: 88; Publication Type: Review; Journal Coden: CCPTAY; Human Indicator: Yes; Section Heading: Drug Metabolism and Body Distribution; Drug Analysis
N2 - The pharmacokinetics of mestranol and ethinyl estradiol, in humans and animals, were reviewed. The GI absorption, blood levels, half-life, protein binding properties, tissue distribution and excretion of these estrogens after oral or IV use are discussed. Different techniques of isolation and identification of metabolites, using gel permeation chromatography and GC/MS, were evaluated.
KW - Ethinyl estradiol--pharmacokinetics-;
KW - Mestranol--pharmacokinetics-;
KW - Pharmacokinetics--ethinyl estradiol--and chromatography, gel permeation, GC/MS, animals, humans, review;
KW - Pharmacokinetics--mestranol--and chromatography, gel permeation, GC/MS, animals, humans, review;
KW - Absorption--ethinyl estradiol--gastrointestinal, blood levels, animals, humans, review;
KW - Absorption--mestranol--gastrointestinal, blood levels, animals, humans, review;
KW - Blood levels--ethinyl estradiol--half-life, protein binding, animals, humans, review;
KW - Blood levels--mestranol--half-life, protein binding, animals, humans, review;
KW - Half-life--ethinyl estradiol--blood levels, protein binding, animals, humans, review;
KW - Half-life--mestranol--blood levels, protein binding, animals, humans, review;
KW - Excretion--ethinyl estradiol--and identification, animals, humans, review;
KW - Excretion--mestranol--and identification, animals, humans, review;
KW - Chromatography, gel permeation--ethinyl estradiol--and metabolites, animals, humans, review;
KW - Chromatography, gel permeation--mestranol--and metabolites, animals, humans, review;
KW - Chromatography, gas--ethinyl estradiol--and mass spectrometry, metabolites, animals, humans, review;
KW - Chromatography, gas--mestranol--and mass spectrometry, metabolites, animals, humans, review;
KW - Tissue levels--ethinyl estradiol--oral, IV, animals, humans, review;
KW - Tissue levels--mestranol--oral, IV, animals, humans, review;
KW - Binding--ethinyl estradiol--proteins, animals, humans, review;
KW - Binding--mestranol--proteins, animals, humans, review;
KW - Metabolism--ethinyl estradiol--review, animals and humans;
KW - Metabolism--mestranol--review, animals and humans;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Kopcho, M. J.;
T1 - Analysis of standards for hospital pharmacies
CT - Analysis of standards for hospital pharmacies
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1977/03/01/
VL - 12
IS - Mar
SP - 183
EP - 192
SN - 00986909
AD - Div. of Quality and Standards, U.S. Public Health Service Region X, Seattle, WA
N1 - Accession Number: 15-3800; Language: English; References: 19; Journal Coden: HOFOD9; Section Heading: Institutional Pharmacy Practice; Abstract Author: Julia A. Roberts
N2 - An analysis of standards for the hospital pharmacy is presented which dimensionalizes health care into 3 components: structure, process, and outcome standards.
KW - Pharmacy, institutional, hospital--standards--discussion;
KW - Standards--hospital pharmacy--practice, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Gershwin, M.E.
AU - Merchant, B.
AU - Steinberg, A.D.
T1 - The effects of synthetic polymeric agents on immune responses of nude mice.
JO - Immunology
JF - Immunology
Y1 - 1977/03//
VL - 32
IS - 3
M3 - Article
SP - 327
SN - 00192805
AB - Investigates the influence of synthetic polymeric agents on the immune responsiveness of congenitally athymic nude mice by determining the effects of in vivo treatment with polynucleotides and polymeric haptenated antigens on splenic theta-bearing cells. Cell responses to thymic dependent and thymic independent antigens; Absence of acquisition of improved T-cell function in nude mice.
KW - IMMUNE response
KW - NUDE mouse
KW - POLYMERS
KW - NUCLEIC acids
N1 - Accession Number: 11161102; Gershwin, M.E. 1,2; Merchant, B. 1,2; Steinberg, A.D. 1,2; Source Information: Mar77, Vol. 32 Issue 3, p327; Subject: IMMUNE response; Subject: NUDE mouse; Subject: POLYMERS; Subject: NUCLEIC acids; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Perez, Maryln K.
T1 - Food and drug administration statement of problem.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 727
EP - 730
SN - 00984108
N1 - Accession Number: 75456792; Perez, Maryln K. 1; Source Information: Mar1977, Vol. 2 Issue 4, p727; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/15287397709529475
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Mercer, H. D.
AU - Baggot, J. D.
AU - Sams, R. A.
T1 - Application of pharmacokinetic methods to the drug residue profile.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 787
EP - 801
SN - 00984108
AB - A pharmacokinetic approach to the delineation of a drug residue profile in food‐producing animals has been presented. It is recognized that the determination of a drug withdrawal period is one of the costly developmental procedures in drug development for food animals; thus it is believed that in the early developmental phases, a thorough pharmacokinetic characterization of a drug in the target species would greatly facilitate the design and quality of studies conducted in the later phases of new drug development. It is suggested that drugs that are intended for use in food animals can be characterized kinetically in less costly studies, the results of which might be used to determine the feasibility of developing a drug that might cause serious residue problems. It is also suggested that the pharmacokinetic modeling of a drug in the target animal may provide an essential data base for calculating dosage rates and intervals that directly relate to the efficacy aspects of drug development. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456796; Mercer, H. D. 1; Baggot, J. D. 2; Sams, R. A. 3; Source Information: Mar1977, Vol. 2 Issue 4, p787; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/15287397709529479
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Thompkins, R. K.;
AU - Burnes, D. C.;
AU - Cable, W. E.;
T1 - Analysis of the cost-effectiveness of pharyngitis management and acute rheumatic fever prevention
CT - Analysis of the cost-effectiveness of pharyngitis management and acute rheumatic fever prevention
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1977/04/01/
VL - 86
IS - Apr
SP - 481
EP - 492
SN - 00034819
AD - Reprints: 1131 Fourteenth Ave. S., Seattle, Washington 98114
AD - Health Services Research, US Public Health Service Hospital and the Dept. of Health Services and Medicine, Univ. of Washington, Seattle, Washington
N1 - Accession Number: 14-5738; Language: English; Chemical Name: Penicillin--1406-05-9; References: 51; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Drug Evaluations
N2 - The cost effectiveness of preventing primary acute rheumatic fever attacks by oral or benzathine penicillin treatment was analyzed for both epidemic and endemic streptococcal pharyngitis situations. Decision analysis was used: the probabilities and the outcome values were calculated from published data. Three strategies of treatment were evaluated in endemic and epidemic situations: (a) treatment of all patients with throat cultures positive for group A Streptococci; (b) treatment of all patients with penicillin without taking a culture; (c) treating none of the patients. It was most cost effective and medically effective to treat all patients in the epidemic situation with penicillin. In the endemic situation treatment with strategy a was most cost effective when the incidence of positive cultures was 5-20%, strategy b was most cost effective when the incidence of positive cultures was 20% or greater; strategy c was most cost effective when the incidence of positive cultures was less then 5%. The use of clinical findings instead of throat cultures may be a cost effective treatment that would require clinical evaluation to confirm. It was concluded that early penicillin treatment for patients with clinical findings suggesting streptococcus pharyngitis is cost effective, is effective in preventing rheumatic fever, and probably decreases the duration of illness.
KW - Penicillin--derivatives-;
KW - Costs--penicillin--derivatives, pharyngitis, therapy, and acute rheumatic fever prophylaxis, patients;
KW - Rational therapy--penicillin--derivatives; pharyngitis therapy and acute rheumatic fever prophylaxis, cost effectiveness, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Herrick, S. S.;
AU - Lawrence, L. R.;
AU - Konvicka, A. J.;
T1 - Source data automation for toxicology research support
CT - Source data automation for toxicology research support
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1977/04/01/
VL - 11
IS - Apr-Jun
SP - 84
EP - 87
SN - 00928615
AD - Computer Linguistics, Inc., Albany, New York and National Center for Toxicological Research, Jefferson, Arkansas 72079
N1 - Accession Number: 14-6272; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: D. L. Thompson
N2 - The establishment of an automated computer system for the collection of toxicology data is discussed with reference to available system types and data collection terminal devices. It was concluded that source data automation is a potentially valuable tool in solving the total toxicology information processing problem.
KW - Automation, data processing, computers--toxicology--information, automated source data collection;
KW - Toxicology--information--computers, automated source data collection;
KW - Information--toxicology--computers, automated source date collection;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=14-6272&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lawrence, L. R.;
AU - Konvicka, A. J.;
AU - Herrick, S. S.;
T1 - Information systems as utilized by the National Center for Toxicological Research
CT - Information systems as utilized by the National Center for Toxicological Research
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1977/04/01/
VL - 11
IS - Apr-Jun
SP - 104
EP - 108
SN - 00928615
AD - National Center for Toxicological Research, Jefferson, Arkansas 72079
N1 - Accession Number: 14-6596; Language: English; Journal Coden: DGIJB9; Section Heading: Information Processing and Literature; Abstract Author: Julia A. Roberts
N2 - An integrated toxicology information system is described including data bases and component systems.
KW - Toxicology--information--National Center for Toxicological Research, system described;
KW - National Center for Toxicological Research--information--integrated, system described;
KW - Automation, data processing, computers--National Center for Toxicological Research--information, integrated system described;
KW - Toxicity--information--National Center for Toxicological Research, integrated system described;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Karney, W. W.;
AU - Pedersen, A. H. B.;
AU - Nelson, M.;
AU - Adams, H.;
AU - Holmes, K. K.;
AU - \ET/;
T1 - Spectinomycin versus tetracycline for the treatment of gonorrhea
CT - Spectinomycin versus tetracycline for the treatment of gonorrhea
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1977/04/21/
VL - 296
IS - Apr 21
SP - 889
EP - 894
SN - 00284793
AD - Div. of Infectious Diseases, US Public Health Service Hospital, Seattle, Washington 98114
N1 - Accession Number: 14-4748; Language: English; Chemical Name: Spectinomycin--1695-77-8 Tetracycline--60-54-8; References: 45; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - To compare the efficacy of spectinomycin and tetracycline in the treatment of gonorrhea, and to test the propensity of these agents to select resistant gonococci, 4,043 patients were treated randomly with either 2 or 4 g of spectinomycin once or 9 g of oral tetracycline for 4 days. Minimum cure rate for anogenital gonorrhea was 94% with either drug. Oropharyngeal infection responded poorly to spectinomycin in men, with failure of therapy in 6 of 11. Postgonococcal urethritis in men was less common after tetracycline than after spectinomycin (P \LT/ 0.005). Spectinomycin failure was not related to drug resistance. Tetracycline failure correlated with resistance (P \LT/ 0.0002); one fifth of the isolates resistant to 1.0 mcg/ml of tetracycline were not eradicated. For several reasons, including the appearance of \b/-lactamase producing gonococci, it is no longer clear that penicillin G is the drug of choice for gonorrhea. Spectinomycin and tetracycline are equally acceptable alternatives, each with distinct advantages and disadvantages.
KW - Spectinomycin--comparison, tetracycline-;
KW - Tetracycline--comparison, spectinomycin-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Defibaugh, P. W.;
AU - Smith, J. S.;
AU - Weeks, C. E.;
T1 - Assay of thiamine in foods, using manual and semiautomated fluorometric and microbiological methods
CT - Assay of thiamine in foods, using manual and semiautomated fluorometric and microbiological methods
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/05/01/
VL - 60
IS - May
SP - 522
EP - 527
AD - Food and Drug Administration, Div. of Nutrition, Washington, D.C. 20204
N1 - Accession Number: 14-5130; Language: English; Chemical Name: Thiamine--59-43-8; References: 19; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - Three methods for determination of thiamine in foods were evaluated for accuracy, recovery, and precision: a manual fluorescent method, a semiautomated fluorescent method, and a Lactobacillus viridescens microbiological assay.
KW - Thiamine--analysis-;
KW - Fluorometry--thiamine--semiautomated, and manual;
KW - Analysis--microbiological--thiamine, comparison, fluorometry;
KW - Food--thiamine--analysis, microbiological and manual and semiautomated fluorometric methods;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Cieri, U. R.;
AU - Illuminati, J. C.;
T1 - Detection and semiquantitative estimation of thyroxine and diiodothyronine in liothyronine sodium
CT - Detection and semiquantitative estimation of thyroxine and diiodothyronine in liothyronine sodium
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/05/01/
VL - 60
IS - May
SP - 628
EP - 634
AD - Food and Drug Administration, 2nd and Chestnut St., Philadelphia, Pennsylvania 19106
N1 - Accession Number: 14-5131; Language: English; Trade Name: T4--T2--T3; Generic Name: Thyroxine; Diiodothyronine; Liothyronine; Chemical Name: Thyroxine--7488-70-2 Liothyronine--6893-02-3; References: 6; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A method is presented for the detection and semiquantitative estimation of thyroxine (I; T4) and diiodothyronine (II; T2) in liothyronine (T3) sodium. I is detected by thin layer chromatography, using silica gel H plates developed in butanol-acetone-ammonia (30:55:15) and sprayed with a 2,7-dichlorofluorescein solution, and estimated by comparison with standard spots. For quantitative results, a larger amount of sample is applied as a streak on a fluorescent plate. After a 5 hr development, the band is scraped off and extracted in a small volume of 0.1N NaOH; the extract is centrifuge, transferred to a 2 cm microcell, and examined spectrophotometrically. The II content of liothyronine sodium is estimated by liquid chromatography on a Bondapak C\IF/18\BS/ column with 0.01N sodium perchlorate-butanol-acetonitrile (1000:62:188) as the eluting solvent.
KW - Thyroxine--chromatography, thin layer-;
KW - Diiodothyronine--chromatography, liquid-;
KW - Liothyronine--purity-;
KW - Chromatography, liquid--diiodothyronine--detection, and semiquantitative estimation, liothyronine;
KW - Chromatography, thin layer--thyroxine--detection, and semiquantitative estimation, liothyronine;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Barron, R. P.;
AU - Benson, W. R.;
AU - Roach, J. A. G.;
T1 - Mass spectral coding technique for identification of drugs and related compounds in reference compendia
CT - Mass spectral coding technique for identification of drugs and related compounds in reference compendia
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/05/01/
VL - 60
IS - May
SP - 635
EP - 641
AD - Food and Drug Administration, Div. of Drug Chemistry, Washington, D.C. 20204
N1 - Accession Number: 14-4836; Language: English; Chemical Name: Trimethadione--127-48-0 Paramethadione--115-67-3; References: 13; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A modification of the spectral abbreviation technique originally described by Hites and Biemann is proposed for identifying compounds through a coding of mass spectral data. Data from 2 closely related compounds (trimethadione and paramethadione), acquired by using 3 instruments, are presented. The technique appears to overcome observed differences in low resolution spectra when the same compound is analyzed by electron impact on mass spectrometers differing in design, manufacturer, principle of ion separation, and operator. A list of spectra coded by this technique could constitute a rapid manual system of reproducing mass spectral data, using the significant high mass ions of low abundance as well as the frequently more abundant lower mass ions. This system is compared with existing systems.
KW - Trimethadione--spectrometry, mass-;
KW - Paramethadione--spectrometry, mass-;
KW - Spectrometry, mass--drugs--identification, coding technique;
KW - Drugs--spectrometry, mass--identification, coding technique;
KW - Codes--spectra--drugs, use, mass spectrometry in identification;
KW - Identification--drugs--spectrometry, mass, coding of spectra;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Stutsman, M. J.;
T1 - Gas-liquid chromatographic determination of solvents in commercial nail lacquer preparations
CT - Gas-liquid chromatographic determination of solvents in commercial nail lacquer preparations
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/05/01/
VL - 60
IS - May
SP - 658
EP - 662
AD - Food and Drug Administration, Div. of Cosmetics Technology, Washington, D.C. 20204
N1 - Accession Number: 14-5133; Language: English; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A GLC method was developed for the determination of 5 solvents (butanol, butyl acetate, ethyl acetate, 2-propanol, and toluene) and camphor in commercial nail lacquer preparations. Resins and pigments are first precipitated from the solvents by dilution with isooctane. n-Propyl acetate is then added as an internal standard to the isooctane solution of solvents and the mixture is analyzed by temperature programmed GLC. Analyses at 3 concentration levels (4, 20, and 40%) with 4 determinations at each level gave good recoveries.
KW - Chromatography, gas--solvents--nail preparations;
KW - Solvents--nail preparations--chromatography, gas;
KW - Nail preparations--solvents--chromatography, gas;
KW - Cosmetics--nail preparations--solvents, GLC;
KW - Camphor--nail preparations--chromatography, gas;
KW - Chromatography, gas--camphor--nail preparations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Beavin, P.;
T1 - Collaborative study of the colorimetric determination of zirconium in antiperspirant aerosols
CT - Collaborative study of the colorimetric determination of zirconium in antiperspirant aerosols
JO - J. Assoc. Off. Anal. Chem.
JF - J. Assoc. Off. Anal. Chem.
Y1 - 1977/05/01/
VL - 60
IS - May
SP - 663
EP - 668
AD - Food and Drug Administration, 1560 E. Jefferson Avenue, Detroit, Michigan 48207
N1 - Accession Number: 14-4829; Language: English; Chemical Name: Zirconium--7440-67-7; Therapeutic Class: (84:00); AHFS Class: Antiperspirants zirconium; References: 2; Journal Coden: JANCA2; Section Heading: Drug Analysis
N2 - A colorimetric method for determining zirconium in antiperspirant aerosols was collaboratively studied by 7 laboratories. The method consists of 2 procedures: a rapid dilution procedure for soluble zirconium compounds or a longer fusion procedure for total zirconium (soluble and insoluble compounds), followed by colorimetry. The average percent zirconium found by the dilution procedure was 0.751 and 0.792%, respectively, with coefficients of variation of 2.94 and 2.53%, respectively. Insufficient collaborative results were received for the fusion procedure for statistical evaluation.
KW - Zirconium--colorimetry-;
KW - Aerosols--zirconium--colorimetry, antiperspirants;
KW - Antiperspirants--zirconium--colorimetry, aerosols;
KW - Colorimetry--zirconium--antiperspirants, aerosols;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Bellman, Sander W
T1 - Symposium on information handling and processing by the food and drug administration
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1977/05//
VL - 17
IS - 2
M3 - Article
SP - 94
EP - 95
SN - 00952338
N1 - Accession Number: ISTA1202957; Bellman, Sander W 1; Affiliations: 1 : Food And Drug Administration, Rockville, Maryland; Source Info: May 1977, Vol. 17 Issue 2, p94; Note: Update Code: 1200; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Horwitz, William
T1 - The establishment of official analytical methodology
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1977/05//
VL - 17
IS - 2
M3 - Article
SP - 97
EP - 102
SN - 00952338
AB - The fda utilizes a wide variety of techniques, which are reviewed, for establishing its official methodology, ranging from a legislative mandate to delegation (with oversight prerogatives) to professional societies. In all cases, the characteristics of the methods are functions of the purpose for which they are intended, rather than the mechanism by which they were established.
N1 - Accession Number: ISTA1203254; Horwitz, William 1; Affiliations: 1 : Bureau Of Foods, Food And Drug Administration, Washington; Source Info: May 1977, Vol. 17 Issue 2, p97; Note: Update Code: 1200; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Eiduson, Hyman P
T1 - Application of tolerances, standards, and methodology in the enforcement of the food, drug, and cosmetic act
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1977/05//
VL - 17
IS - 2
M3 - Article
SP - 102
EP - 105
SN - 00952338
AB - The fda quality assurance program for its 20 field laboratories, the use of standards established by officially recognized organizations, the national check sample program, and the quality assurance audit visit program are described.
N1 - Accession Number: ISTA1203252; Eiduson, Hyman P 1; Affiliations: 1 : Us Food And Drug Administration, Rockville, Maryland; Source Info: May 1977, Vol. 17 Issue 2, p102; Note: Update Code: 1200; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Cairns, Thomas
AU - Jacobson, Robert A
T1 - New approaches to fda analytical problems
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1977/05//
VL - 17
IS - 2
M3 - Article
SP - 105
EP - 109
SN - 00952338
AB - The formulation of a molecular weight listing of pesticides and industrial chemicals is described. Application to residue analysis by mass spectrometry is reported. A novel approach to quantitation of polychlorinated biphenyls is presented.
N1 - Accession Number: ISTA1203251; Cairns, Thomas 1; Jacobson, Robert A; Affiliations: 1 : Us Food And Drug Administration, Los Angeles; Source Info: May 1977, Vol. 17 Issue 2, p105; Note: Update Code: 1200; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Highman, B.
AU - Gaines, T. B.
AU - Schumacher, H. J.
T1 - Retarded development of fetal renal alkaline phosphatase in mice given 2,4,5‐trichlorophenoxyacetic acid.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1007
EP - 1018
SN - 00984108
AB - Histologic study of the fetal offspring of maternal mice given 2,4,5‐trichlorophenoxy‐acetic acid (2,4,5‐T) suggested that the previously reported fetal “cystic kidneys” were due to a retardation in fetal renal development and downgrowth of the renal papilla into the pelvis. To determine a possible retardation in renal alkaline phosphatase or functional development, maternal mice received by gavage 60–120 mg/kg, 2,4,5‐T on days 6–14 of pregnancy. At necropsy on day 17, the fetal kidneys were excised and fixed 24 hr in cold 65% ethanol. Paraffin sections stained by Gomori's method revealed alkaline phosphatase mainly in tubules in the inner renal cortex. Fetal kidneys showing diminished or no alkaline phosphatase were designated subnormal. There was a statistically significant greater incidence of subnormal fetal kidneys in the 2,4,5‐T‐treated mice than in the untreated controls. In three experiments, some mice were also sacrificed on day 18, and the incidence of subnormal fetal kidneys was significantly lower than on day 17. This retardation in renal alkaline phosphatase development indicates a retardation in renal functional development and indirectly supports the view that 2,4,5‐T also retards the morphological development of the fetal kidney and is not a renal teratogen in mice. It also illustrates that selected histochemical studies may be helpful in a teratologic investigation. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456843; Highman, B. 1,2; Gaines, T. B. 3; Schumacher, H. J. 3; Source Information: May1977, Vol. 2 Issue 5, p1007; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287397709529499
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Freudenthal, Ralph I.
AU - Kerchner, Gail A.
AU - Persing, Ronald L.
AU - Baumel, Irwin
AU - Baron, Ronald L.
T1 - Subacute toxicity of ethylenebisisothiocyanate sulfide in the laboratory rat.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1067
EP - 1078
SN - 00984108
AB - Ethylenebisisothiocyanate sulfide (EBIS) was administered in the diet to groups of rats at 0, 1, 10, 100, and 1,000 ppm for up to 90 days. The rats receiving EBIS at 1,000 ppm demonstrated a toxic response within 8–14 days, reflected as a reversible paralysis of the hind legs. If left on the 1,000 ppm diet, the animals soon died. When removed from the diet, the animals recovered, only to become atoxic on further dietary exposure at the high level. No histologic lesion could be identified in either H&E‐ or luxol fast blue‐stained sections of brain, spinal cord, or peripheral nerves from the paralyzed animals. The ability to reverse the paralysis by removing the animals from the test diet coupled with the lack of histologically observable lesions suggests a biochemical (reversible) rather than somatic lesion. Ingestion of 1,000 ppm EBIS for 7 days resulted in measurable changes in thyroid function. Total serum thyroxine levels were markedly decreased, as was iodide uptake by the thyroid. Ingestion of EBIS at dietary levels of 100, 10, 1, and 0 ppm for 90 days produced no observable adverse effect. Growth, as seen by body weight increases, diet consumption, and thyroid function, was normal. No EBIS‐related lesions were detected during the histopathologic evaluation of major tissues and organs taken from rats fed 100 ppm EBIS or control diets. In this 90 day dietary study with EBIS, no effects were noted at a level of 100 ppm in the diet, equivalent to an average intake ranging from 67 mg/kg body weight at week 1 to 31 mg/kg body weight at week 12. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456848; Freudenthal, Ralph I. 1; Kerchner, Gail A. 2; Persing, Ronald L. 2; Baumel, Irwin 3,4; Baron, Ronald L. 5; Source Information: May1977, Vol. 2 Issue 5, p1067; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287397709529504
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Haley, Thomas J.
T1 - Maleic hydrazide: Should the Delaney amendment apply to its use?
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1085
EP - 1094
SN - 00984108
AB - The chemistry, metabolism, toxicology, mutagenicity, and carcinogenicity of maleic hydrazide have been reviewed. There is little doubt that this chemical is a mutagen and a carcinogen in cell cultures and animals, but no evidence is available on human carcinogenicity regardless of population exposure in manufacturing, agriculture, and the food chain (i.e., potato chips). An epidemiology survey should be conducted to ascertain possible human carcinogenicity in these populations. A long‐term ingestion experiment should be conducted in several animal species to establish whether maleic hydrazide is carcinogenic by this route. Biotransformation studies should be undertaken along with pharmacokinetic studies to obtain a better understanding of the chemical's metabolism and excretion. Such investigations would firmly establish whether the tolerance for maleic hydrazide should remain or whether the use of the compound should be banned under the Delaney Amendment. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456850; Haley, Thomas J. 1; Source Information: May1977, Vol. 2 Issue 5, p1085; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397709529506
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Davis, James E.
AU - Cranmer, Morris F.
AU - Peoples, Anita J.
T1 - Effects of diphenylhydantoin and chloroquine on monkey liver microsomal mixed‐function oxidases.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1193
EP - 1199
SN - 00984108
AB - Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed‐function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed‐function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456861; Davis, James E. 1; Cranmer, Morris F. 2; Peoples, Anita J. 3; Source Information: May1977, Vol. 2 Issue 5, p1193; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15287397709529517
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Sobotka, Thomas J.
AU - Brodie, Robert E.
AU - Spaid, Stephen L.
T1 - Tartrazine and the developing nervous system of rats.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1211
EP - 1220
SN - 00984108
AB - Rat dams were exposed to the artificial food color tartrazine (FD&C Yellow no. 5) at dietary levels of 0, 1, and 2% during gestation and lactation. The experimental offspring were continued on the same diets for approximately 3 months after weaning. No adverse physical or behavioral effects were noted in the dams. Fetal development and postnatal viability of the offspring were also normal. The only effect on postnatal development of the central nervous system (CNS) was a small transient change in neuromotor clinging ability of female offspring. The limited effect of tartrazine on the CNS was further evidenced by the facts that (1) the neurobehavioral profiles of the experimental weanlings revealed no significant abnormalities, and (2) morphochemical analysis of brain tissue, as well as brain weights, revealed no abnormalities. Tartrazine did appear to exert more general signs of toxicity in the off spring‐namely, depressed body weight, an apparent reduction in thymus weight, and a slight elevation of red blood cells and hemoglobin. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456863; Sobotka, Thomas J. 1; Brodie, Robert E. 2; Spaid, Stephen L. 2; Source Information: May1977, Vol. 2 Issue 5, p1211; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397709529519
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1978-20886-001
AN - 1978-20886-001
AU - Anderson, John E
AU - Morris, L.
AU - Stroh, G.
AU - Conn, J.
AU - Gesche, M. C.
T1 - Contraceptive use: Prevalence among married women in Albany, New York, Health Region, 1974.
JF - New York State Journal of Medicine
JO - New York State Journal of Medicine
JA - N Y State J Med
Y1 - 1977/05//
VL - 77
IS - 6
SP - 933
EP - 937
CY - US
PB - Medical Society of the State of New York
SN - 0028-7628
N1 - Accession Number: 1978-20886-001. PMID: 266124 Partial author list: First Author & Affiliation: Anderson, John E; USDHEW Public Health Service, Ctr for Disease Control, Atlanta, GA. Release Date: 19780701. Correction Date: 20130422. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Birth Control; Contraceptive Devices; Socioeconomic Status; Statistical Sample Parameters; Wives. Classification: Marriage & Family (2950). Population: Human (10); Female (40). Page Count: 5. Issue Publication Date: May, 1977.
AB - Found that the use of contraceptives by married women in the Albany, New York, health region in 1974 was similar to that in a national sample in 1973. Women with less education and women living in lower socioeconomic status areas used contraception less frequently. Private physicians were the most important source of information about contraception. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - data from education & socioeconomic status
KW - contraceptive use
KW - married females
KW - comparison of state health region vs national sample
KW - 1977
KW - Birth Control
KW - Contraceptive Devices
KW - Socioeconomic Status
KW - Statistical Sample Parameters
KW - Wives
KW - 1977
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - SAWYER, THOMAS K.
AU - VISVESVARA, GOVINDA S.
AU - HARKE, BRUCE A.
T1 - Pathogenic Amoebas from Brackish and Ocean Sediments, with a Description of Acanthamoeba hatchetti, n. sp.
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1324
EP - 1325
SN - 00368075
AB - Acanthamoeba culbertsoni was isolated from a sewage-spoil dump site near Ambrose Light, New York Bight. A second species, Acanthamoeba hatchetti, n. sp., was isolated from Brewerton Channel, Baltimore Harbor, Maryland. Both species killed laboratory mice after infection by the intranasal route. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218460; SAWYER, THOMAS K. 1; VISVESVARA, GOVINDA S. 2; HARKE, BRUCE A. 3; Affiliations: 1: National Marine Fisheries Service, U.S. Department of Commerce, Oxford, Maryland 21654; 2: Parasitology Division, Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333; 3: National Marine Fisheries Service, U.S. Department of Commerce, Oxford; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1324; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CRAWFORD, GEORGE
AU - KNAPP, JOAN S.
AU - HALE, JUDITH
AU - HOLMES, KING K.
T1 - Asymptomatic Gonorrhea in Men: Caused by Gonococci with Unique Nutritional Requirements.
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1352
EP - 1353
SN - 00368075
AB - In a retrospective case-control study, gonococci with nutritional requirements for arginine, hypoxanthine, and uracil were recovered from 24 of 25 men with asymptomatic gonorrhea and 10 of 25 men with symptomatic gonorrhea (P = .0001). These strains represent a smaller proportion of gonococcal isolates fromn blacks than from whites. Asymptomatic urethral infection is important in the epidemiology of gonorrhea, particularly among whites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85218472; CRAWFORD, GEORGE 1; KNAPP, JOAN S. 1; HALE, JUDITH 1; HOLMES, KING K. 1; Affiliations: 1: Division of Infectious Diseases, U.S. Public Health Service Hospital, Seattle, Washington 98114; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1352; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - STOLOFF, LEONARD
AU - MISLIVEC, PHILIP
AU - SCHINDLER, A. F.
AU - MORGAN-JONES, G.
T1 - Aspergillus oryzae (NRRL Strain 1988).
JO - Science
JF - Science
Y1 - 1977/06/17/
VL - 196
IS - 4296
M3 - Article
SP - 1353
EP - 1354
SN - 00368075
N1 - Accession Number: 85218473; STOLOFF, LEONARD 1; MISLIVEC, PHILIP 1; SCHINDLER, A. F. 1; MORGAN-JONES, G. 2; Affiliations: 1: Bureau of Foods, Food and Drug Administration, Washington, D.C. 20204; 2: Department of Botany and Microbiology, Auburn University, Auburn, Alabama 36830; Issue Info: 6/17/1977, Vol. 196 Issue 4296, p1353; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoofnagle, Jay H.
AU - Gerety, Robert J.
AU - Tabor, Edward
AU - Feinstotne, Stephen M.
AU - Barker, Lewellys F.
AU - Purcell, Robert H.
T1 - Transmission of Non-A, Non-B Hepatitis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 14
EP - 20
SN - 00034819
AB - In studies conducted In the early 1950s, an from six asymptomatic blood donors, Implicated In the transmission of viral hepatitis, were Inoculated Into 10 to 20 volunteers each. Five of these "Implicated" donor sera transmitted clinically apparent hepatitis to the recipients. The stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis B virus and hepatitis A virus Infection. Two of the donor we were hepatitis B surface antigen (HBsAg)-positive, and both transmitted hepatitis B virus infection to all susceptible recipients, half of whom showed clinical symptoms. The remaining three Infectious donors were HBsAg-negative, yet were Icterogenic to 10% to 47% of recipients. Testing of serum samples from these recipients with hepatitis showed no evidence of hepatitis B virus or hepatitis A virus Infection. This study and other recent evidence suggest that there is a third type of human viral hepatitis--non-A, non-B hepatitis-which is due to a transmissible agent and may well be associated with a chronic carrier state. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - LIVER diseases
KW - BLOOD donors
KW - VIRAL hepatitis
KW - SERUM
KW - VIRUSES
N1 - Accession Number: 14147581; Hoofnagle, Jay H. 1,2; Gerety, Robert J. 1,2; Tabor, Edward 1,2; Feinstotne, Stephen M. 1,2; Barker, Lewellys F. 1,2; Purcell, Robert H. 1,2; Source Information: Jul77, Vol. 87 Issue 1, p14; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: BLOOD donors; Subject: VIRAL hepatitis; Subject: SERUM; Subject: VIRUSES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Meyers, Joel D.
AU - Jules L. Dienstag
AU - Robert H. Purcell
AU - E. Donnall Thomas
AU - King K. Holmes
T1 - Parenterally Transmitted Non-A, Non-B Hepatitis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1977/07//
VL - 87
IS - 1
M3 - Article
SP - 57
EP - 59
SN - 00034819
AB - in 1912 a nosocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. Because of the characteristics of the clinical illness, the Incubation period of 27 days, and the effect of Immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis A; there was no serologic evidence of either hepatitis B virus or cytomegalovirus infection. Stored serums from this outbreak were re-examined by more recently developed serologic techniques for evidence of hepatitis A (HA) virus infection. Ten patients and donors had undetectable anti-HA titers before illness and none seroconverted; five persons had pre-existent anti-HA titers and showed no further rise in convalescent serums. The serum of one patient was inevaluable. With the availability of serologic techniques for the diagnosis of both hepatitis A and hepatitis B virus infections, it is clear that most cases of post-transfusion hepatitis are not due to either of these agents, and shorts incubation-period hepatitis can not be assumed to be hepatitis A without further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - LIVER diseases
KW - NOSOCOMIAL infections
KW - IMMUNOGLOBULINS
KW - CYTOMEGALOVIRUS diseases
KW - HERPESVIRUS diseases
N1 - Accession Number: 14150883; Meyers, Joel D. 1,2,3; Jules L. Dienstag 1,2,3; Robert H. Purcell 1,2,3; E. Donnall Thomas 1,2,3; King K. Holmes 1,2,3; Source Information: Jul77, Vol. 87 Issue 1, p57; Subject: HEPATITIS; Subject: COMMUNICABLE diseases; Subject: LIVER diseases; Subject: NOSOCOMIAL infections; Subject: IMMUNOGLOBULINS; Subject: CYTOMEGALOVIRUS diseases; Subject: HERPESVIRUS diseases; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Goeden, G. R.;
AU - Hill, R.;
AU - Gladhart, W. R.;
AU - Urner, C. J.;
T1 - Successful system for reviewing drug therapy
CT - Successful system for reviewing drug therapy
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1977/07/01/
VL - 12
IS - Jul
SP - 478
EP - 481
SN - 00986909
AD - Pharm. Dept., U.S. Public Health Service Hosp., New Orleans, LA
N1 - Accession Number: 15-6449; Language: English; Chemical Name: Gentamicin--1403-66-3; References: 6; Journal Coden: HOFOD9; Section Heading: Methodology; Institutional Pharmacy Practice; Abstract Author: Julia A. Roberts
N2 - The usefulness of the Joint Commission on Accreditation of Hospitals Patient Care Audit Procedure in drug utilization audits in hospitals is discussed. The use of the standard JCAH audit form in a gentamicin injection drug utilization review audit is demonstrated. It is concluded that drug utilization review is the essence of improvement of drug therapy, the pharmacist is responsible for promoting the system, and the JCAH audit forms provide a good approach to reporting this information.
KW - Gentamicin--drug utilization-;
KW - Drug utilization--review--forms, JCAH, discussion;
KW - Joint Commission on Accreditation of Hospitals--forms--drug utilization, review, discussion;
KW - Forms--drug utilization--review, JCAH, discussion;
KW - Methodology--drug utilization--review, gentamicin forms, JCAH, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - NOBLE, ERNEST P.
T1 - Wine and Viral Diseases.
JO - Science
JF - Science
Y1 - 1977/07/15/
VL - 197
IS - 4300
M3 - Article
SP - 208
EP - 210
SN - 00368075
N1 - Accession Number: 87459846; NOBLE, ERNEST P. 1; Affiliations: 1: National Institute on Alcohol Abuse and Alcoholism, Public Health Service, Rockville, Maryland 20852; Issue Info: 7/15/1977, Vol. 197 Issue 4300, p208; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILSTIEN, JULIE B.
AU - WALKER, JAMES R.
AU - PETRICCIANI, JOHN C.
T1 - Bacteriophages in Live Virus Vaccines: Lack of Evidence for Effects on the Genome of Rhesus Monkeys.
JO - Science
JF - Science
Y1 - 1977/07/29/
VL - 197
IS - 4302
M3 - Article
SP - 469
EP - 470
SN - 00368075
AB - Four juvenile rhesus monkeys were inoculated with 1012 plaque-forming units ofthe bacteriophage 4VI isolatedfrom live virus vaccines. After XVI had been cleared from the blood, DNA's were isolated from the livers and kidneys and analyzed for the presence of bacteriophage by plaque assays, and for the presence of ΦVI DNA by DNA-DNA reassociation kinetics. No evidence was found for persistence of the bacteriophage orfor replication of the phage genome in these rhesus monkeys. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87519139; MILSTIEN, JULIE B. 1; WALKER, JAMES R. 1; PETRICCIANI, JOHN C. 1; Affiliations: 1: Division of Pathology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014; Issue Info: 7/29/1977, Vol. 197 Issue 4302, p469; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moo-Penn, Winston F.
AU - Schmidt, Robert M.
AU - Jue, Danny L.
AU - Bechtel, Katherine C.
AU - Wright, Jane M.
AU - Horne III, McDonald K.
AU - Haycraft, Gordon L.
AU - Roth Jr., Eugene F.
AU - Nagel, Ronald L.
T1 - Hemoglobin S Travis: a Sickling Hemoglobin with Two Amino Acid Substitutions [β6(A3)Glutamic Acid → Valine and β142(H2O)Alanine → Valine].
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1977/08//8/1/77
VL - 77
IS - 3
M3 - Article
SP - 561
EP - 566
SN - 00142956
AB - Hb S Travis is a previously undescribed sickling hemoglobin with two amino acid substitutions in the β chain: β6 Glu→Val and β142 Ala→Val. The β6 Glu→Val mutation imparts to Hb S Travis the characteristic properties of sickling hemoglobin, namely its association with erythrocyte sickling, the insolubility of the hemoglobin in the reduced form, and a minimum gelling concentration value identical to Hb S. Unlike Hb S, Hb S Travis exhibits an increased oxygen affinity and a decreased affinity for 2,3-bisphosphoglycerate and inositol hexakisphosphate. In addition, the variant hemoglobin's tendency to autoxidize and its mechanical precipitability suggest that there are conformational differences between Hb S and Hb S Travis. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - AMINO acids
KW - ERYTHROCYTES
KW - BLOOD proteins
KW - GELATION
KW - INOSITOL
N1 - Accession Number: 13746195; Moo-Penn, Winston F. 1; Schmidt, Robert M. 1; Jue, Danny L. 1; Bechtel, Katherine C. 1; Wright, Jane M. 1; Horne III, McDonald K. 2; Haycraft, Gordon L. 2; Roth Jr., Eugene F. 3; Nagel, Ronald L. 3; Source Information: 8/1/77, Vol. 77 Issue 3, p561; Subject: HEMOGLOBIN; Subject: AMINO acids; Subject: ERYTHROCYTES; Subject: BLOOD proteins; Subject: GELATION; Subject: INOSITOL; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Fusillo, Alice E.
AU - Beloian, Arletta M.
T1 - Consumer Nutrition Knowledge and Self Reported Food Shopping Behavior.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/09//
VL - 67
IS - 9
M3 - Article
SP - 846
PB - American Public Health Association
SN - 00900036
AB - In 1975 a national sample of consumers was questioned about their knowledge of nutrition, beliefs about food, and their shopping behavior. Findings indicate a particular need for education related to facts about iron, thiamin, riboflavin, and vitamins A and D. Consumers with low knowledge tended to have less education, lower income, and less prestigious occupations. Of these variables, educational achievement level had the strongest association to low nutrition knowledge. Using an index based on the three socioeconomic variables, low knowledge was more often present among the male and older shoppers, with age having the stronger association. Association of the three indices of nutrition knowledge, food beliefs, and reported shopping behavior were found to be positive and linear. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Consumer behavior
KW - Food consumption
KW - Consumers
KW - Nutrition -- Study & teaching
KW - Grocery shopping
KW - Academic achievement
KW - Socioeconomics
KW - Social surveys
KW - United States
N1 - Accession Number: 5666997; Fusillo, Alice E. 1; Beloian, Arletta M. 1; Affiliations: 1: Division of Consumer Studies, Food and Drug Administration; Issue Info: Sep77, Vol. 67 Issue 9, p846; Thesaurus Term: Consumer behavior; Thesaurus Term: Food consumption; Subject Term: Consumers; Subject Term: Nutrition -- Study & teaching; Subject Term: Grocery shopping; Subject Term: Academic achievement; Subject Term: Socioeconomics; Subject Term: Social surveys; Subject: United States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Chatterji, D. C.;
AU - Gallelli, J. F.;
T1 - High pressure liquid chromatographic analysis of methotrexate in presence of its degradation products
CT - High pressure liquid chromatographic analysis of methotrexate in presence of its degradation products
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1977/09/01/
VL - 66
IS - Sep
SP - 1219
EP - 1222
SN - 00223549
AD - Pharmacy Dept., Clinical Ctr., Public Health Service, NIH, Bethesda, MD 20014
N1 - Accession Number: 15-2186; Language: English; Chemical Name: Methotrexate--59-05-2; References: 4; Journal Coden: JPMSAE; Section Heading: Drug Analysis
N2 - Two high pressure liquid chromatographic methods are described for the quantitative determination of methotrexate (I) in the presence of its contaminants and degradation products. The first method takes less than 15 min and is recommended for routine assays of I in commercial products. The second method takes about 35 min and is the method of choice to detect and quantitate large amounts of degradation products. Quantitation to a level of one mcg I/ml is feasible by these methods and thus provides potential applicability for the analysis of I in biological fluids.
KW - Methotrexate--chromatography, liquid-;
KW - Chromatography, liquid--methotrexate--high pressure, quantitative, with contaminants, comparison of methods;
KW - Contamination--methotrexate--chromatography, liquid, high pressure, comparison of methods;
KW - Stability--methotrexate--chromatography, liquid, high pressure;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1980-07736-001
AN - 1980-07736-001
AU - Townsley, H. C.
AU - Goldstein, George S.
T1 - One view of the etiology of depression in the American Indian.
JF - Health Services Reports
JO - Health Services Reports
JA - Health Serv Rep
Y1 - 1977/09//Sep-Oct, 1977
VL - 92
IS - 5
SP - 458
EP - 461
CY - US
PB - U. S. Public Health Service
SN - 0090-2918
N1 - Accession Number: 1980-07736-001. PMID: 910023 Other Journal Title: H.S.M.H.A. Health Reports; Public Health Reports. Partial author list: First Author & Affiliation: Townsley, H. C.; US Public Health Service, Albuquerque, NM. Other Publishers: Association of Schools of Public Health; Elsevier Science; Oxford University Press; U.S. Dept. of Health, Education, and Welfare, Health Services and Mental Health Administration; U.S. Marine Hospital Service. Release Date: 19800401. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Depression (Emotion); Etiology. Classification: Psychological Disorders (3210); Culture & Ethnology (2930). Population: Human (10). Page Count: 4. Issue Publication Date: Sep-Oct, 1977.
AB - Hypothesizes that depression in American Indians is rooted in their passive dependence on government services, leading to lack of control over their lives. Chronically high unemployment rates, lack of education, and prejudicial victimization also contribute. It is recommended that American Indians be allowed to be responsible for policy and planning for their tribes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - passive dependence on government services & social factors in etiology of depression
KW - American Indians
KW - 1977
KW - American Indians
KW - Depression (Emotion)
KW - Etiology
KW - 1977
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Brown, S. T.;
AU - Pederson, A. H.;
AU - Holmes, K. K.;
T1 - Comparison of erythromycin base and estolate in gonococcal urethritis
CT - Comparison of erythromycin base and estolate in gonococcal urethritis
JO - J. Am. Med. Assoc.
JF - J. Am. Med. Assoc.
Y1 - 1977/09/26/
VL - 238
IS - Sep 26
SP - 1371
EP - 1373
AD - Center for Disease Control, Atlanta, Georgia; and the Seattle-King County, Health Dept. and the Dept. of Medicine, Univ. of Washington, and the US Public Health Service Hospital, Seattle, Washington) (Reprints: Center for Disease Control, Technical Information Services, Bureau of State Services, Atlanta, Georgia 30333
N1 - Accession Number: 15-0107; Language: English; Chemical Name: Erythromycin--114-07-8; References: 8; Journal Coden: JAMAAP; Human Indicator: Yes; Section Heading: Biopharmaceutics; Drug Evaluations
N2 - A randomized double blind trial of 152 men with gonococcal urethritis compared the therapeutic efficacy of erthromycin (I) estolate and I base. Twenty-one of 86 (24%) men treated with the estolate and 15 of 66 (23%) treated with the base had recurrent or persistent gonococcal infection when seen after a 9 g course of I. The serum I activity among estolate treated patients (3.57 \PM/ 0.84 mcg/ml) was nearly twice that for base treated patients (1.76 \PM/ 0.80 mcg/ml). The recommended erythromycin regimen is relatively ineffective for gonococcal infection of men. Although similar observations are unavailable for pregnant women, results do not support the routine use of erythromycin for treatment of pregnant, penicillin allergic women. Women treated with this drug must be carefully followed up and tested after treatment, since at least one fourth will remain infected.
KW - Erythromycin--base, comparison, estolate-;
KW - Erythromycin--estolate, comparison, base-;
KW - Rational therapy--erythromycin--base, comparison, estolate, gonococcal urethritis, and blood levels, patients;
KW - Blood levels--erythromycin--base, comparison, estolate, gonococcal urethritis, and rational therapy, patients;
KW - Equivalency--erythromycin--base, comparison, estolate, gonococcal urethritis, blood levels and rational therapy, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Horwitz, Marcus A.
AU - Pollard, Robert A.
AU - Merson, Michael H.
AU - Martin, Stanley M.
T1 - A Large Outbreak of Foodborne Salmonellosis On the Navajo Nation Indian Reservation, Epidemiology and Secondary Transmission.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/11//
VL - 67
IS - 11
M3 - Article
SP - 1071
PB - American Public Health Association
SN - 00900036
AB - In September 1974, the largest outbreak of foodbome salmonellosis ever reported to the Center for Disease Control—affecting an estimated 3,400 persons -occurred on the Navajo Nation Indian Reservation. The responsible agent was Salmonella newport and the vehicle of transmission was potato salad served to an estimated 11,000 persons at a free barbecue. The cooked ingredients of the potato salad had been stored for up to 16 hours at improper holding temperatures. The magnitude of the outbreak allowed us to study secondary transmission by calculating the rates of diarrheal illness during the 2 weeks following the outbreak in persons who did not attend the barbecue and by examining the results of stool cultures obtained after the outbreak. We found no secondary transmission. We conclude that a health official should monitor food preparation and service at large social gatherings and that person-to-person transmission of salmonellosis probably does not normally occur even in settings considered highly conducive to cross-infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food poisoning
KW - Foodborne diseases
KW - Epidemics
KW - Public health
KW - Salmonella food poisoning
KW - Salmonella diseases -- Transmission
KW - Diarrhea
KW - Cooking (Potatoes)
KW - Food service
N1 - Accession Number: 5662347; Horwitz, Marcus A. 1; Pollard, Robert A. 1; Merson, Michael H. 1; Martin, Stanley M. 1; Affiliations: 1: Bacterial Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, GA 30333; Issue Info: Nov77, Vol. 67 Issue 11, p1071; Thesaurus Term: Food poisoning; Thesaurus Term: Foodborne diseases; Thesaurus Term: Epidemics; Thesaurus Term: Public health; Subject Term: Salmonella food poisoning; Subject Term: Salmonella diseases -- Transmission; Subject Term: Diarrhea; Subject Term: Cooking (Potatoes); Subject Term: Food service; NAICS/Industry Codes: 722330 Mobile Food Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FENSELAU, CATHERINE
AU - PALLANTE, SHARON
AU - BATZINGER, ROBERT P.
AU - BENSON, WALTER R.
AU - BARRON, ROBERT P.
AU - SHEININ, ERIC B.
AU - MAIENTHAL, MILLARD
T1 - Mandelonitrile β-Glucuronide: Synthesis and Characterization.
JO - Science
JF - Science
Y1 - 1977/11/11/
VL - 198
IS - 4317
M3 - Article
SP - 625
EP - 627
SN - 00368075
AB - Mandelonitrile β-glucuronide, the compound patented as Laetrile®, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with Salmonella typhimurium strains TA 98 and TA 100. Several commercial laetrile preparations contained no glucuronide; they contained amygdalin and neoamygdalin instead. Mandelonitrile, mandelonitrile glucuronide, and a mixture of amygdalin and neoamygdalin were each found to be mutagenic. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460717; FENSELAU, CATHERINE 1; PALLANTE, SHARON 1; BATZINGER, ROBERT P. 1; BENSON, WALTER R. 2; BARRON, ROBERT P. 2; SHEININ, ERIC B. 2; MAIENTHAL, MILLARD 2; Affiliations: 1: Johns Hopkins University Medical Institutions, Baltimore, Maryland 21205; 2: Division of Drug Chemistry, U.S. Food and Drug Administration, Washington, D.C. 20204; Issue Info: 11/11/1977, Vol. 198 Issue 4317, p625; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Hoffman, P. C.;
AU - Dixon, R. E.;
T1 - Control of influenza in the hospital
CT - Control of influenza in the hospital
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1977/12/01/
VL - 87
IS - Dec
SP - 725
EP - 728
SN - 00034819
AD - Cent. for Disease Control, Public Health Service, Dept. of HEW, Atlanta, GA
N1 - Accession Number: 15-4842; Language: English; Chemical Name: Amantadine hydrochloride--665-66-7; Therapeutic Class: (8:18); AHFS Class: Virucides amantadine hydrochloride; References: 39; Journal Coden: AIMEAS; Section Heading: Drug Evaluations
N2 - Vaccinating hospital personnel with influenza vaccine and, if influenza A is prevalent, giving amantadine hydrochloride to high risk patients or personnel should both be considered in the control of influenza.
KW - Amantadine hydrochloride--influenza-;
KW - Influenza vaccines--immunization-;
KW - Virucides--amantadine hydrochloride--influenza, use in high risk patients and hospital personnel, discussion;
KW - Immunization--influenza--vaccines, use in hospital personnel, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Grubbs, Ruth E
T1 - Conceptual model for screening and indexing of documents for a multidisciplinary information system
JO - Conceptual model for screening and indexing of documents for a multidisciplinary information system
JF - Conceptual model for screening and indexing of documents for a multidisciplinary information system
Y1 - 1978///
M3 - Book
AB - A task force, assigned to the development of a computerized current research system on occupational safety and health, designed a matrix to help evaluate the relevance of research projects for input. since the selection of relevant documents concerns other information systems in the national institute for occupational safety and health (niosh), a relevancy matrix was constructed for the current research system (crs) which could be used as a model for screening input for all niosh information retrieval systems. In addition, the matrix provided the basis for the crs's indexing vocabulary
N1 - Accession Number: ISTA1500441; Grubbs, Ruth E 1; Affiliations: 1 : National Institute For Occupational Safety And Health; Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Morgan, Vivian Kay
AU - Schoenborn, Theodore F
T1 - Development and implementation of a publications dissemination program for the national institute for occupational safety and health
JO - Development and implementation of a publications dissemination program for the national institute for occupational safety and health
JF - Development and implementation of a publications dissemination program for the national institute for occupational safety and health
Y1 - 1978///
M3 - Book
AB - The publications development program of the national institute for occupational safety and health (niosh) grew from two publications in 1972 to a printing of 750,000 copies of 125 publications in 1977. Because of the increased number of niosh publications and the size of the intended audience, it was necessary to develop a dissemination program so that institute publications would reach those who needed the information
N1 - Accession Number: ISTA1500366; Morgan, Vivian Kay; Schoenborn, Theodore F 2; Affiliations: 2 : National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Gelberg, A
T1 - Drug information utilization-the need for government/industry communications
JO - Drug Information Journal 12, 163-166 (1978 July-september)
JF - Drug Information Journal 12, 163-166 (1978 July-september)
Y1 - 1978///
M3 - Book Chapter
AB - The drug information transfer from the regulated industries or the users of the product to the fda is discussed. Information systems within the fda which aid in the communication process are discussed. The chemical information system, the ind/nda technical information system, and the clinical investigator/facilities system are briefly described.
N1 - Accession Number: ISTA1400283; Gelberg, A 1; Affiliations: 1 : Division Of Drug Information Resources, Bureau Of Drugs, Food And Drug Administration; Source Info: 1978; Note: Update Code: 1400; Document Type: Book Chapter
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
TY - GEN
AU - Johnson, K. T.;
T1 - Errors in prescription dispensing can be reduced with counseling
CT - Errors in prescription dispensing can be reduced with counseling
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1978/01/01/
VL - 13
IS - Jan
SP - 51
EP - 55
SN - 00986909
AD - Pharm. Dept., US Public Health Service Hosp., Baltimore, MD
N1 - Accession Number: 15-5358; Language: English; Journal Coden: HOFOD9; Section Heading: Institutional Pharmacy Practice; Abstract Author: Nicole M. Areson
N2 - The results of a voluntary pharmacy checking system carried out over an 8 month period in a hospital are reported. A total of 65 dispensing errors of all types was reported, which is an incidence rate of one in every 1100 prescriptions. The most common errors were the following: wrong drug, wrong instructions for use, wrong strength and prescription left out of bag. Errors were mostly detected during the requisite daily check of all prescriptions by the pharmacist, on a voluntary basis. It was noted that an important aspect of the reporting system, which relies on voluntary initiation of the report, is proper motivation and rational counseling of the person who makes an error.
KW - Errors, medication--prescriptions--dispensing, voluntary checking system, discussion;
KW - Control--prescriptions--dispensing, voluntary checking system, discussion;
KW - Prescriptions--dispensing--control, voluntary checking system, discussion;
KW - Pharmacists--role--errors, medication, voluntary checking of prescription dispensing, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hicks, H.;
AU - McGhee, R.;
AU - Lentini, E.;
AU - Zelonis, A.;
T1 - Patient's medication profile keeps the records straight
CT - Patient's medication profile keeps the records straight
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1978/01/01/
VL - 13
IS - Jan
SP - 58
EP - 60
SN - 00986909
AD - US Public Health Service Outpatient Clinic, New York City, and US Public Health Service Hosp., Staten Island, NY
N1 - Accession Number: 15-4714; Language: English; References: 5; Journal Coden: HOFOD9; Section Heading: Information Processing and Literature; Abstract Author: Nicole M. Areson
N2 - The development of a wallet size drug information card is described. This system proved useful in detecting duplicated drug orders, and orders for interacting drugs. Disadvantages included lack of patient compliance, the necessity of updating the card by physicians and pharmacists, and lack of space to enter the quantity of medication or the date dispensed.
KW - Prescriptions--drug information--forms, identification card, advantages and disadvantages;
KW - Control--prescriptions--forms, identification card, advantages and disadvantages;
KW - Patient information--prescriptions--control, identification card, advantages and disadvantages;
KW - Drug interactions--prescriptions--control, identification card, discussion;
KW - Forms--drug information--identification card, advantages and disadvantages;
KW - Drug information--forms--identification card, advantages and disadvantages;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Schoenborn, Theodore F
T1 - Information user needs survey--a decision guide for resource allocation
JO - Information user needs survey--a decision guide for resource allocation
JF - Information user needs survey--a decision guide for resource allocation
Y1 - 1978///
M3 - Book
AB - The clearinghouse for occupational safety and health information, as the technical information center for the national institute for occupational safety and health, supports information services at 6 research locations. A user survey was conducted to identify needed information services and to determine satisfaction with existing services of the clearinghouse
N1 - Accession Number: ISTA1500225; Schoenborn, Theodore F 1; Affiliations: 1 : National Institute For Occupational Safety And Health, Cincinnati, Oh; Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Mullaney, Judith L
T1 - Input rejection algorithm used to provide quality control for nioshtic input
JO - Input rejection algorithm used to provide quality control for nioshtic input
JF - Input rejection algorithm used to provide quality control for nioshtic input
Y1 - 1978///
M3 - Book
AB - Nioshtic is the on-line data base of the national institute for occupational safety and health. An algorithm which uses ranked or weighted input errors for documents rejection was developed to systematically control quality in every document batch. Application of the algorithm allows batches of documents to be evaluated objectively, thereby reducing some of the inconsistencies that plague document retrieval systems
N1 - Accession Number: ISTA1500460; Mullaney, Judith L 1; Affiliations: 1 : National Institute For Occupational Safety And Health; Source Info: 1978; Note: Update Code: 1500; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 1980-02028-001
AN - 1980-02028-001
AU - Hammerschlag, Carl A.
AU - Alderfer, Clayton P.
AU - Berg, David
T1 - Group relation and the expression of aggression among American Indian tribes.
JF - Corrective & Social Psychiatry & Journal of Behavior Technology, Methods & Therapy
JO - Corrective & Social Psychiatry & Journal of Behavior Technology, Methods & Therapy
JA - Correct Soc Psych J Behav Tech Methods Ther
Y1 - 1978///
VL - 24
IS - 2
SP - 62
EP - 76
CY - US
PB - Martin Psychiatric Research Foundation
SN - 0093-1551
N1 - Accession Number: 1980-02028-001. Partial author list: First Author & Affiliation: Hammerschlag, Carl A.; US Public Health Service, Div of Indian Health, Phoenix, AZ. Release Date: 19800101. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aggressive Behavior; Intergroup Dynamics; School Attendance; School Dropouts; Self-Esteem. Minor Descriptor: American Indians; Ethnic Values; School Adjustment; Student Attitudes; Tribes. Classification: Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10). Page Count: 15. Issue Publication Date: 1978.
AB - Utilized open systems theory and cross-level hypotheses to determine individual, intragroup, and intergroup explanations for the expression of aggression at an American Indian school. Survey methods were used to gather tribal affiliation data, behavioral information, and attitude measures. Tribe 1 showed the highest level of aggressiveness (both individual and group), with individual aggression fitting the clinical depressive syndrome. Drop-out and self-respect data indicated that Tribe 1 members were suffering the most from attending the school. Tribe 4 members reported the highest increase in self-respect as a function of being at the school, and had nearly the lowest drop-out rate. They perceived the least intra- and intertribal fighting and the most intratribal support. As individuals, they seemed to be the most adequately adjusted. Tribes 2 and 3 had richer, more complex emotional lives than the other groups and exchanged more positive and negative reactions. Their individual and group relations served them better than those of Tribe 1, and their group relations were more functional than those of Tribe 4. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - school attendance
KW - individual & group aggression & self esteem & dropout rate
KW - American Indian tribes
KW - 1978
KW - Aggressive Behavior
KW - Intergroup Dynamics
KW - School Attendance
KW - School Dropouts
KW - Self-Esteem
KW - American Indians
KW - Ethnic Values
KW - School Adjustment
KW - Student Attitudes
KW - Tribes
KW - 1978
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Overpeck, James G.
AU - Colson, Sylvia H.
AU - Hohmann, John R.
AU - Applestine, Marshall S.
AU - Reilly, Joseph F.
T1 - Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 785
EP - 803
SN - 00984108
AB - Radioimmunoassay (RIA) data on concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters have been collated from the literature. Few reports include data for both sexes, for age groups, or for more than one species. In selecting references for inclusion in the tables, efforts were made to choose data only from RIA procedures that were adequately validated. A number of similarities can be found by reviewing the tables. Levels of estradiol appear somewhat similar for humans, chimpanzees, and rhesus monkeys of both sexes. Among the notable differences are the levels of estradiol and progesterone in primates and rodents, the apparently high level of aldosterone in mice, and the patterns of progesterone secretion in mice and rats. All values in the tables have been converted to picograms for easy comparison between steroids and species. Data for humans are fairly complete, but there is a significant lack of information for several other species. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196189; Overpeck, James G. 1; Colson, Sylvia H. 2; Hohmann, John R. 2; Applestine, Marshall S. 2; Reilly, Joseph F. 2; Source Information: Jan1978, Vol. 4 Issue 5/6, p785; Number of Pages: 19p; Document Type: Article
L3 - 10.1080/15287397809529700
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Ong, Tong‐man
AU - Slade, Barbara
T1 - Mutagenicity and mutagenic specificity of metronidazole and niridazole in neurospora crassa.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 815
EP - 824
SN - 00984108
AB - Mutagenicity and mutagenic specificity of niridazole and metronidazole, two chemotherapeutic agents used in the treatment of human parasitic diseases, were studied with the ad‐3 test system of Neurospora crassa. The results show that neither compound is mutagenic in resting conidia. In growing vegetative cells, however, both compounds are mutagenic in N. crassa. Genetic analysis of the mutants indicated that niridazole induces predominantly base‐pair substitution mutations. None of the niridazole‐induced mutants resulted from multilocus deletions. The spectra of genetic alterations induced by metronidazole are similar to those induced by the mono‐functional alkylating agents ethyleneimine (El), ethylmethanesulfonate (EMS), and ICR‐177. It is therefore suggested that the mechanism of mutation induction by metronidazole in Neurospora is similar to that of monofunctional alkylating agents. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196191; Ong, Tong‐man 1,2; Slade, Barbara 1; Source Information: Jan1978, Vol. 4 Issue 5/6, p815; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397809529702
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - YOUNG, RONALD J.
AU - RINSKY, ROBERT A.
AU - INFANTE, PETER F.
AU - WAGONER, JOSEPH K.
T1 - Benzene in Consumer Products.
JO - Science
JF - Science
Y1 - 1978/01/20/
VL - 199
IS - 4326
M3 - Article
SP - 248
EP - 248
SN - 00368075
N1 - Accession Number: 87460107; YOUNG, RONALD J. 1; RINSKY, ROBERT A. 1; INFANTE, PETER F. 1; WAGONER, JOSEPH K. 2; Affiliations: 1: Industry-Wide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Center for Disease Control, 4676 Columbia Parkway, Cincinnati, Ohio 45226; 2: Office, Assistant Secretary, Occupational Safety and Health Administration, Washington, D.C. 20210; Issue Info: 1/20/1978, Vol. 199 Issue 4326, p248; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MALONEY, CLIFFORD J.
T1 - Decision-Making: What Basis?
JO - Science
JF - Science
Y1 - 1978/02/24/
VL - 199
IS - 4331
M3 - Article
SP - 841
EP - 841
SN - 00368075
N1 - Accession Number: 87460837; MALONEY, CLIFFORD J. 1; Affiliations: 1: Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014; Issue Info: 2/24/1978, Vol. 199 Issue 4331, p841; Number of Pages: 1/8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1981-06025-001
AN - 1981-06025-001
AU - Peniston, Eugene G.
AU - Burman, William
T1 - Relaxation and assertive training as treatment for a psychosomatic American Indian patient.
JF - White Cloud Journal of American Indian/Alaska Native Mental Health
JO - White Cloud Journal of American Indian/Alaska Native Mental Health
Y1 - 1978///Spr 1978
VL - 1
IS - 1
SP - 7
EP - 10
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0190-2482
N1 - Accession Number: 1981-06025-001. Other Journal Title: American Indian and Alaska Native Mental Health Research; White Cloud Journal of American Indian Mental Health. Partial author list: First Author & Affiliation: Peniston, Eugene G.; Ute & Ouray Indian Health Service, Roosevelt, UT. Release Date: 19810301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Anxiety; Assertiveness Training; Progressive Relaxation Therapy; Somatoform Disorders. Minor Descriptor: Case Report; Followup Studies; Hostility. Classification: Behavior Therapy & Behavior Modification (3312). Population: Human (10). Methodology: Clinical Case Study; Empirical Study; Followup Study. Page Count: 4. Issue Publication Date: Spr 1978.
AB - A 33-yr-old American Indian woman with psychosomatic complaints and anxiety-hostility was given progressive muscle relaxation and assertiveness training over a 16-wk period. S's symptoms disappeared during treatment and were found nonexistent at 2- and 4-wk follow-ups, replicating results obtained with Ss of other cultural backgrounds. (14 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - progressive muscle relaxation & assertiveness training
KW - psychosomatic complaints & anxiety-hostility
KW - 33 yr old female American Indian
KW - 2 & 4-wk followups
KW - 1978
KW - American Indians
KW - Anxiety
KW - Assertiveness Training
KW - Progressive Relaxation Therapy
KW - Somatoform Disorders
KW - Case Report
KW - Followup Studies
KW - Hostility
KW - 1978
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - NOGUCHI, PHILIP D.
AU - JOHNSON, JOYCE B.
AU - O'DONNELL, ROBERT
AU - PETRICCIANI, J. C.
T1 - Chick Embryonic Skin as a Rapid Organ Culture Assay for Cellular Neoplasia.
JO - Science
JF - Science
Y1 - 1978/03/03/
VL - 199
IS - 4332
M3 - Article
SP - 980
EP - 983
SN - 00368075
AB - We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87460870; NOGUCHI, PHILIP D. 1; JOHNSON, JOYCE B. 1; O'DONNELL, ROBERT 1; PETRICCIANI, J. C. 1; Affiliations: 1: Experimental Biology Branch, Division of Pathology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland 20014; Issue Info: 3/3/1978, Vol. 199 Issue 4332, p980; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Donald F.
T1 - Pellagra deaths in the United States.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1978/04//
VL - 31
IS - 4
M3 - Article
SP - 558
EP - 558
SN - 00029165
N1 - Accession Number: 94355779; Miller, Donald F. 1; Affiliations: 1: Nutritionist, Office of Nutrition and Consumer Sciences, Food and Drug Administration, Washington, D. C., 20204; Issue Info: Apr1978, Vol. 31 Issue 4, p558; Number of Pages: 3/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Mechanisms of Contraction of the Normal and Failing Heart.
AU - Preston, Thomas A.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1978/04//
VL - 1
IS - 2
SP - 278
EP - 279
SN - 01478389
N1 - Accession Number: 17377059; Author: Preston, Thomas A.: 1 ; Author Affiliation: 1 Dept. of Health, Education and Welfare, U.S. Public Health Service Hospital, P.O. Box 3145, Seattle, Washington 98114, U.S.A.; No. of Pages: 2; Language: English; Publication Type: Book Review; Update Code: 20050621
N2 - Reviews the book "Mechanisms of Contraction of the Normal and Failing Heart."
KW - *HEART failure
KW - *HEART diseases
KW - NONFICTION
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Leong, D.
AU - Coe, J.E.
T1 - Metabolism of homologous and heterologous serum proteins in garter snakes ( Thamnophis ordinoides ).
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 931
EP - 937
SN - 00192805
AB - The half life (T½) of serum immunoglobulin (Ig) and albumin from snakes and mammals were determined in both garter snakes (Thamnophis ordinoides) and mice (Mus musculus). Metabolism of serum proteins in snakes was similar to mammalian protein metabolism in that homologous serum albumin had shorter T½ (16 days) than IgG (38 days). Also, reptilian and mammalian serum proteins had a relatively longer T½ when injected into closely related species. Thus mammalian serum Ig (rabbit gamma globulin (RGG)) had a shorter T½ (6.3 days) in snake than did homologous snake IgG (38 days), whereas in mice, RGG had a longer T½ (3.8 days) than snake Ig (0.9 days). Differences between metabolism of homologous and heterologous albumins were apparent only in snakes in which the T½. of homologous albumin was approximately 8-fold greater than mammalian albumin. These results indicate that metabolism of both Ig and albumin in snakes is regulated by specific receptors whereas albumin receptors have been difficult to demonstrate in mammals. The results of this study suggest that one of the factors determining the metabolism of a protein is its foreignness to the host perhaps because of receptor cross reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD proteins
KW - GARTER snakes
KW - THAMNOPHIS ordinoides
KW - IMMUNOGLOBULINS
KW - PROTEIN metabolism
KW - MAMMALS
KW - SERUM
KW - ALBUMINS
N1 - Accession Number: 13930713; Leong, D. 1; Coe, J.E. 1; Source Information: May78, Vol. 34 Issue 5, p931; Subject: BLOOD proteins; Subject: GARTER snakes; Subject: THAMNOPHIS ordinoides; Subject: IMMUNOGLOBULINS; Subject: PROTEIN metabolism; Subject: MAMMALS; Subject: SERUM; Subject: ALBUMINS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Snippe, H.
AU - Johannesen, Lynne
AU - Inman, J.K.
AU - Merchant, B.
T1 - Specificity of murine delayed-type hypersensitivity to conjugates of large or small haptens on protein carriers bearing lipid groups.
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 947
EP - 954
SN - 00192805
AB - Delayed-type hypersensitivity (DH) in the mouse was provoked with different haptencarrier complexes mixed with the cationic, surfaceactive lipid, dimethyl dioctadecyl ammonium bromide (DDA). DH was measured as footpad swelling.Conjugates of bovine serum albumin (BSA) with the small haptens dinitrophenyl (DNP), 'arsonate'(ARS) and 'sulphonate' (SULPH) served to generate strong DH reactions towards the homologous antigen. Insertion of a tripeptide spacer between the hapten and carrier resulted in lower DH reactivity. Optimal dosages and optimal time intervals between sensitization and DH elicitation were determined for the enlarged hapten-carrier complexes. Cyclophosphamide (CY) treatment, before priming with complexes mixed with DDA, caused a 5-6 day delay in the expression of DH but failed to evoke enhanced DH for any of the antigens tested. A broad array of cross reactions between small and enlarged hapten-carrier complexes showed a relative lack of specificity in these DH responses. The results are compared with others reported in the literature and are explained mainly by the effects of electrostatically bound lipid groups of DDA in the sensitizing conjugates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DELAYED hypersensitivity
KW - MICE
KW - SERUM albumin
KW - HAPTENS
KW - ANTIGENS
KW - CARRIER proteins
KW - BROMIDES
N1 - Accession Number: 13932691; Snippe, H. 1; Johannesen, Lynne 1; Inman, J.K. 1; Merchant, B. 1; Source Information: May78, Vol. 34 Issue 5, p947; Subject: DELAYED hypersensitivity; Subject: MICE; Subject: SERUM albumin; Subject: HAPTENS; Subject: ANTIGENS; Subject: CARRIER proteins; Subject: BROMIDES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - HERMAN, WILLIAM A.
T1 - Potential Hazards.
JO - Science
JF - Science
Y1 - 1978/05/12/
VL - 200
IS - 4342
M3 - Article
SP - 643
EP - 645
SN - 00368075
N1 - Accession Number: 87519271; HERMAN, WILLIAM A. 1; Affiliations: 1: U.S. Food and Drug Administration, Bureau of Radiological Health, Rockville, Maryland 20857; Issue Info: 5/12/1978, Vol. 200 Issue 4342, p643; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1980-02403-001
AN - 1980-02403-001
AU - Haertzen, C. A.
AU - Ross, F. E.
T1 - Using four chance profiles to evaluate carelessness.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 1978/06//
VL - 42
IS - 3, Pt 2
SP - 1079
EP - 1087
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
N1 - Accession Number: 1980-02403-001. Partial author list: First Author & Affiliation: Haertzen, C. A.; HEW Public Health Service, Addiction Research Ctr, Lexington, KY. Other Publishers: Sage Publications. Release Date: 19800201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Errors; Evaluation; Test Scores. Classification: Tests & Testing (2220). Population: Human (10). Page Count: 9. Issue Publication Date: Jun, 1978.
AB - By comparing the similarity of an S's scores with individualized chance scores, a test can be validly evaluated for carelessness. A fixed individualized chance score on any scale for an S can be estimated with the S's total percentage of true responses. A sum of D–2/100 is then determined between the actual and chance scores. The method is regarded as generally applicable to tests that have many scales. Using the Social Experience Questionnaire 100% of random tests and 3.7% of actual tests for 54 normal Ss, 53 alcoholics, and 28 opiate addicts (from a study by W. R. Martin et al, 1977) had cutting scores of 40 or less. (4 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chance profiles from Social Experience Questionnaire
KW - test taking carelessness evaluation
KW - normal & alcoholic & opiate addict Ss
KW - 1978
KW - Errors
KW - Evaluation
KW - Test Scores
KW - 1978
DO - 10.2466/pr0.1978.42.3c.1079
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Pheifer, T. A.;
AU - Forsyth, P. S.;
AU - Durfee, M. A.;
AU - Pollock, H. M.;
AU - Holmes, K. K.;
T1 - Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole
CT - Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1978/06/29/
VL - 298
IS - Jun 29
SP - 1429
EP - 1434
SN - 00284793
AD - Div. of Infectious Diseases, Dept. of Med., U.S. Public Health Service Hosp., 1131 4th Ave. S., Seattle, WA 98114
N1 - Accession Number: 15-5699; Language: English; Trade Name: Sultrin cream; Generic Name: Sulfabenzamide; Chemical Name: Metronidazole--443-48-1 Ampicillin--69-53-4 Doxycycline--17086-28-1 Sulfabenzamide--127-71-9 Sulfacetamide--144-80-9 Sulfathiazole--72-14-0; Therapeutic Class: (8:32); AHFS Class: Trichomonacides metronidazole, comparison, ampicillin, doxycycline, sulfonamides (84:24); AHFS Class: Creams sulfabenzamide, combination, sulfacetamide, sulfathiazole; References: 29; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - A prospective case control study of vaginal flora to assess the cause of nonspecific vaginitis and a randomized unblinded trial of different therapies involving the use of oral ampicillin (I), doxycycline (II), metronidazole (III) and Sultrin cream (IV; sulfabenzamide, 3.7%, combination, sulfacetamide, 2.86%, sulfathiazole, 3.42%) in 110 women are reported. I was given 500 mg 4 times/day for 7 days, II, 100 mg 2 times/day for 7 days, III, 500 mg 2 times/day for 7 days, and IV inserted vaginally 2 times/day for 10 days. \IT/H. vaginalis\OK/ was isolated from 17 of 18 women with signs of vaginitis but only one of 18 normal matched controls. The concentration of anaerboic bacteria in vaginal washings also was increased in patients. Clinical improvement and eradication of \IT/H. vaginalis\OK/ occurred in one of 7 patients given IV, 2 of 15 given II, 9 of 27 given I, and 80 of 81 given III. On the seventh day of therapy, signs of nonspecific vaginitis persisted in 31 of 31 with, and in 2 of 92 without, persistent \IT/H. vaginalis\OK/ infection. These data suggest the causal role of \IT/H. vaginalis\OK/ in nonspecific vaginitis, possibly in concert with vaginal anaerobes. The widespread use of IV is inappropriate. III is effective, but its efficacy must be weighed against its possible toxicity.
KW - Metronidazole--comparison, ampicillin, doxycycline, sulfonamides-;
KW - Ampicillin--comparison, doxycycline, metronidazole, sulfonamides-;
KW - Doxycycline--comparison, ampicillin, metronidazole, sulfonamides-;
KW - Sulfabenzamide--combination, sulfacetamide, sulfathiazole-;
KW - Sulfacetamide--combination, sulfabenzamide, sulfathiazole-;
KW - Sulfathiazole--combination, sulfabenzamide, sulfacetamide-;
KW - Trichomonacides--metronidazole, comparison, ampicillin, doxycycline, sulfonamides--vaginitis, nonspecific, H. vaginalis, patients;
KW - Creams--sulfabenzamide, combination, sulfacetamide, sulfathiazole--comparison, ampicillin, doxycycline, metronidazole, nonspecific vaginitis, H. vaginalis, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Swango, P. A.;
T1 - What you should know about fluorides
CT - What you should know about fluorides
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1978/07/01/
VL - 44
IS - Jul
SP - 60
EP - 67
SN - 00030627
AD - Natl. Inst. of Dental Res., NIH, Public Health Service, Bethesda, MD 20014
N1 - Accession Number: 16-5782; Language: English; Journal Coden: PYTMAO; Section Heading: Pharmacology; Drug EvaluationsSociology, Economics and Ethics; Abstract Author: Walter F. Stanaszek
N2 - The various means by which fluoride can be utilized as an anti-caries agent in the home, in school programs, or community wide are reviewed. Water fluoridation, currently being done in approximately 6800 communities offers the advantage of low cost, decline in dental caries of up to 50%, and elimination of need for compliance. Daily fluoride (tablets, lozenges, or drops) supplements are effective alternatives in fluoride-deficient areas if regularly administered from birth to 14 yr. Dosages vary with age of the child and amount of fluoride present in the water. Topical fluorides, in the form of dentifrices, mouth rinses or concentrated solutions or gels, are of particular value for individuals who have not had the advantage of systemic fluoride during tooth formation. Topical fluorides may also provide an increased degree of protection when used in conjunction with systemic fluorides. Various methods of approaching the use of topical fluorides are discussed and compared in terms of products, effectiveness and limitations.
KW - Fluorides--caries--prophylaxis, oral dosage forms;
KW - Dosage forms--fluorides--caries, prophylaxis, tablets, lozenges, drops, topical preparations;
KW - Dosage--fluorides--caries, prophylaxis, tablets, lozenges, drops, topical preparations;
KW - Topical preparations--fluorides--caries, prophylaxis;
KW - Tablets--fluorides--caries, prophylaxis;
KW - Solutions--fluorides--caries, prophylaxis;
KW - Gels--fluorides--caries, prophylaxis;
KW - Mouthwashes--fluorides--caries, prophylaxis;
KW - Lozenges--fluorides--caries, prophylaxis;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=16-5782&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Zelonis, A. R.;
T1 - Monitoring drug therapy: a practical approach
CT - Monitoring drug therapy: a practical approach
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1978/08/01/
VL - 13
IS - Aug
SP - 602
EP - 607
SN - 00986909
AD - Pharm. Dept., US Public Health Service Hosp., Staten Island, NY
N1 - Accession Number: 16-2870; Language: English; References: 5; Journal Coden: HOFOD9; Section Heading: Institutional Pharmacy Practice; Abstract Author: Elvira deC. Weiss
N2 - A drug therapy monitoring program organized to improve patient care is described. The program utilizes the pharmacist's knowledge in a structured, organized format.
KW - Pharmacists, hospital--patient care--monitoring, drug therapy;
KW - Patient care--pharmacists, hospital--monitoring, drug therapy;
KW - Clinical pharmacists--patient care--monitoring, drug therapy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=16-2870&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1981-05667-001
AN - 1981-05667-001
AU - Peniston, Eugene G.
T1 - The Ego Strength scale as a predictor of Ute Indian suicide risk.
JF - White Cloud Journal of American Indian/Alaska Native Mental Health
JO - White Cloud Journal of American Indian/Alaska Native Mental Health
Y1 - 1978///Fal 1978
VL - 1
IS - 2
SP - 17
EP - 19
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0190-2482
N1 - Accession Number: 1981-05667-001. Other Journal Title: American Indian and Alaska Native Mental Health Research; White Cloud Journal of American Indian Mental Health. Partial author list: First Author & Affiliation: Peniston, Eugene G.; US Public Health Service, Indian Health Ctr, Roosevelt, UT. Release Date: 19810301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; American Indians; Attempted Suicide; Depression (Emotion); Personality Correlates. Minor Descriptor: Ego. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Page Count: 3. Issue Publication Date: Fal 1978.
AB - MMPI scores on the Depression and Ego Strength scales for a random sample of 30 17–59 yr old Ute suicidal outpatients were correlated with the number of suicide attempts and the number of attempts made while drinking alcohol. Raw scores on the Ego Strength scale were significantly correlated with the number of suicide attempts. All Ss with low scores on the Ego Strength scale had been drinking alcohol when they attempted suicide. (12 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MMPI scores on Depression & Ego Strength scales & alcohol drinking
KW - suicide attempts
KW - Ute Indians
KW - 1978
KW - Alcohol Drinking Patterns
KW - American Indians
KW - Attempted Suicide
KW - Depression (Emotion)
KW - Personality Correlates
KW - Ego
KW - 1978
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1981-05667-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KENNEDY, DONALD
T1 - Drug Regulation.
JO - Science
JF - Science
Y1 - 1978/09/08/
VL - 201
IS - 4359
M3 - Article
SP - 866
EP - 866
SN - 00368075
N1 - Accession Number: 87546864; KENNEDY, DONALD 1; Affiliations: 1: Food and Drug Administration, Rockville, Maryland 20857; Issue Info: 9/8/1978, Vol. 201 Issue 4359, p866; Number of Pages: 1/3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=87546864&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06387-035
AN - 2006-06387-035
AU - Stolz, Stephanie B.
T1 - The Same Old Song.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1978/10//
VL - 23
IS - 10
SP - 753
EP - 755
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06387-035. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Stolz, Stephanie B.; Division of Alcoholism, Drug Abuse, and Mental Health Programs, DHEW Public Health Service Regional Office, Kansas City, MO, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Bioethics; Mental Disorders; Morale; Psychiatry; Theology. Minor Descriptor: Involuntary Treatment. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Reviewed Item: Szasz, Thomas. The Theology of Medicine: The Political-Philosophical Foundations of Medical Ethics=Baton Rouge: Louisiana State University Press, 1977. Pp. xxii + 170. $8.95; 1977. Page Count: 3. Issue Publication Date: Oct, 1978.
AB - Reviews the book, The Theology of Medicine: The Political-Philosophical Foundations of Medical Ethics by Thomas Szasz (1977). In 1961, Szasz startled the psychological and psychiatric world with The Myth of Mental Illness, in which contended that psychiatric intervention with involuntary patients was fundamentally immoral. He charged then, as he does again in The Theology of Medicine, that mental hospital patients are innocents incarcerated in psychiatric prisons, that institutional psychiatry is an extralegal system of punishments and penology, and that mental illness is a metaphor-a quasi-medical label used to conceal conflicts of values and to justify coercion of the patients. In Szasz's view, the only moral option in a free society is the complete abolition of involuntary psychiatric intervention, and reliance instead on the legal system. Szasz's provocative writings have forced many professionals to re-examine their fundamental assumptions about the nature of mental health and mental illness, and their justifications for the treatments they provide. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental illness
KW - mental hospital patients
KW - involuntary psychiatric intervention
KW - psychiatry
KW - medicine
KW - medical ethics
KW - 1978
KW - Bioethics
KW - Mental Disorders
KW - Morale
KW - Psychiatry
KW - Theology
KW - Involuntary Treatment
KW - 1978
U2 - Szasz, Thomas. (1977); The Theology of Medicine: The Political-Philosophical Foundations of Medical Ethics; Baton Rouge: Louisiana State University Press, 1977. Pp. xxii + 170. $8.95
DO - 10.1037/016569
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06387-035&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Acne drug doesn't mix with sun
CT - Acne drug doesn't mix with sun
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1978/11/01/
VL - 12
IS - Nov
SP - 12
EP - 13
SN - 03621332
AD - Public Health Service, FDA, 5600 Fishers Lane Rockville, MD 20857
N1 - Accession Number: 16-3458; Language: English; Trade Name: Retin-A--Aberel--Retinoic acid; Generic Name: Tretinoin; Tretinoin; Tretinoin; Chemical Name: Tretinoin--302-79-4; Journal Coden: FDACBH; Section Heading: Toxicity; Abstract Author: Julia A. Delaney
N2 - Recent research results with hairless mice suggesting that tretinoin (retinoic acid; Retin-A; Aberel; I) may increase the risk of skin cancer upon exposure to sunlight are discussed. The recommendations and warnings of the Food and Drug Administration and American Academy of Dermatology regarding the use of I for the treatment of acne in humans are given.
KW - Tretinoin--interactions-;
KW - Toxicity--tretinoin--interactions, radiation, UV, cancer, skin, increased, mice, humans, discussion;
KW - Toxicity--radiation--ultraviolet, interactions, tretinoin, cancer, skin, mice, humans, discussion;
KW - Radiation--ultraviolet--interactions, tretinoin, toxicity, cancer, skin, increased, mice, humans, discussion;
KW - Food and Drug Administration (U.S.)--tretinoin--interactions, radiation, UV, recommendations, use, toxicity, mice, humans, discussion;
KW - American Academy of Dermatology--tretinoin--interactions, radiation, UV, recommendations, use, toxicity, mice, humans, discussion;
KW - Acne--tretinoin--interactions, radiation, ultraviolet, toxicity, cancer, skin, mice, humans, discussion;
KW - Contraindications--tretinoin--interactions, radiation, ultraviolet, toxicity, cancer, skin, mice, humans, discussion;
KW - Drug interactions--tretinoin and radiation, ultraviolet--toxicity, cancer, skin, mice, humans, discussion;
KW - Drug interactions--radiation, ultraviolet and tretinoin--toxicity, cancer, skin, mice, humans, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=16-3458&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - Drug effects on the eye
CT - Drug effects on the eye
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1978/11/01/
VL - 12
IS - Nov
SP - 14
EP - 15
SN - 03621332
AD - Public Health Service, FDA, 5600 Fishers Lane, Rockville, MD 20857
N1 - Accession Number: 16-2910; Language: English; Chemical Name: Ampicillin--69-53-4 Nalidixic acid--389-08-2 Chloral hydrate--302-17-0; Therapeutic Class: (28:24); AHFS Class: Sedatives and hypnotics chloral hydrate; Journal Coden: FDACBH; Section Heading: Toxicity; Abstract Author: Julia A. Delaney
N2 - The National Registry of Possible Drug Induced Ocular Side Effects established in 1975 by the Food and Drug Administration in order to make physicians aware that some drugs such as ampicillin, nalidixic acid and chloral hydrate may cause side effects to the eye is discussed.
KW - Ampicillin--toxicity-;
KW - Nalidixic acid--toxicity-;
KW - Chloral hydrate--toxicity-;
KW - Toxicity--drugs--side effects, eye, National Registry of Possible Drug Induced Ocular Side Effects, information, physicians, discussion;
KW - Drug information--toxicity--eye, physicians, National Registry of Possible Drug Induced Ocular Side Effects, discussion;
KW - National Registry of Possible Drug Induced Ocular Side Effects--drug information--toxicity, eye, use, physicians, discussion;
KW - Sedatives and hypnotics--chloral hydrate--toxicity, eye, information, physicians, discussion;
KW - Food and Drug Administration (U.S.)--National Registry of Possible Drug Induced Ocular Side Effects--drug information, toxicity, eye, physicians, discussion;
KW - Physicians--drug information--toxicity, eye, National Registry of Possible Drug Induced Ocular Side Effects;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=16-2910&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Hecht, A.;
T1 - IUD's and pelvic infection
CT - IUD's and pelvic infection
JO - FDA Consumer (USA)
JF - FDA Consumer (USA)
Y1 - 1978/11/01/
VL - 12
IS - Nov
SP - 21
SN - 03621332
AD - Public Health Service, FDA, 5600 Fishers Lane, Rockville, MD 20857
N1 - Accession Number: 16-3461; Language: English; Journal Coden: FDACBH; Section Heading: Toxicity; Information Processing and Literature; Abstract Author: Julia A. Delaney
N2 - Changes in patient and physician package insert labeling of intrauterine devices required by the Food and Drug Administration which include warnings that women who use IUD's are more likely than nonusers to develop pelvic inflammatory disease are discussed.
KW - Contraceptives, intrauterine devices--toxicity--infections, pelvic, patient information, and physicians, FDA requirements, discussion;
KW - Toxicity--contraceptives, intrauterine devices--infections, pelvic, patient information, and physicians, FDA requirements, discussion;
KW - Patient information--package inserts--contraceptives, intrauterine devices, side effects, infections, pelvic, discussion;
KW - Food and Drug Administration (U.S.)--patient information--contraceptives, intrauterine devices, labeling, side effects, pelvic infections, discussion;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=16-3461&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gomes, J. A.;
AU - Dhatt, M. S.;
AU - Akhtar, M.;
AU - Carambas, C. R.;
AU - Rubenson, D. S.;
AU - \ET/;
T1 - Effects of digitalis on ventricular myocardial and His-Purkinje refractoriness and reentry in man
CT - Effects of digitalis on ventricular myocardial and His-Purkinje refractoriness and reentry in man
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
Y1 - 1978/12/01/
VL - 42
IS - Dec
SP - 931
EP - 938
AD - Cardiology Dept. U.S. Public Health Service Hosp., Staten Island, NY 10304
N1 - Accession Number: 17-00385; Language: English; Chemical Name: Ouabain--11018-89-6; Therapeutic Class: (24:04); AHFS Class: Cardiac drugs ouabain; References: 32; Journal Coden: AJCDAG; Human Indicator: Yes; Section Heading: Pharmacology
N2 - The effects of ouabain (I) on retrograde conduction and refractoriness of the His-Purkinje system, ventricular myocardium and reentry within the His-Purkinje system were studied in 17 patients using the ventricular extrastimulus (V\IF/2\BS/) technique. Studies were performed, before and 30 min after IV administration of I, 0.01 mg/kg. After treatment with I there was a significant decrease in the functional refractory period (266 to 254 msec), relative refractory period (253 to 240 msec), and effective refractory period (242 to 231 msec) of the ventricular muscle. In contrast, there was no significant change in retrograde His-Purkinje conduction and refractoriness. I increased and shifted to the left the zone of reentry within the His-Purkinje system in 7 of 10 patients (36 to 55 msec) and decreased it by 10 to 30 msec in the remaining 3 patients. The critical V\IF/2\BS/-H\IF/2\BS/ (186 to 193 msec, difference not significant (NS) and V\IF/1\BS/-V\IF/2\BS/ (299 to 294 msec, NS) intervals for reentry did not significantly change after ouabain. However, the minimal V\IF/1\BS/-V\IF/2\BS/ intervals (266 to 253 msec) decreased significantly, whereas the maximal V\IF/2\BS/-H\IF/2\BS/ intervals (266 to 239 msec) increased significantly. Thus, in the intact human heart, I significantly decreased all measures of ventricular myocardial refractoriness, had no significant effect on retrograde conduction and refractoriness of the His-Purkinje system, and widened the zone of reentry within the His-Purkinje system due to shortening of the functional refractory period of the ventricular muscle with attainment of longer V\IF/2\BS/-H\IF/2\BS/ delays.
KW - Ouabain--effects-;
KW - Cardiac drugs--ouabain--effects, ventricular myocardial and His-Purkinje refractoriness, patients;
KW - Mechanism of action--ouabain--effects, cardiac, ventricular myocardial and His-Purkinje refractoriness, patients;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=17-00385&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Snippe, H.
AU - Merchant, B.
AU - Johannessen, L.
AU - Inman, J. K.
T1 - Effects of cyclophosphamide on the in vivo response of outbred athymic (nude) mice to a thymus-independent antigen (DNP-AGG-Ficoll).
JO - Immunology
JF - Immunology
Y1 - 1978/12//
VL - 35
IS - 6
M3 - Article
SP - 1009
EP - 1015
SN - 00192805
AB - Both nude mice (nu/nu) and their heterozygous littermates (nu/+) were injected with a single IP dose of 300 mg cyclophosphamide (CY)/kg. CY is a known immunosuppressive agent, which affects primarily B lymphocytes. Immunization with the thymus independent antigen DNP-AGG59- Ficoll after CY treatment disclosed that restoration of the primary direct PFC response occurred more rapidly in nude mice than in nu/+ mice. However in these same experiments, the primary indirect PFC response, recovered earlier in nu/+ mice than in nude mice. After CY treatment, secondary indirect PFC responses were delayed in both nude and nu/+ mice, but the greatest effect was seen in nude mice. The data suggest that the presence of T cells has little if any influence on the recovery capacity of those B cells which are destined to become direct PFC. However the recovery of B cells which are destined to produce indirect PFC responses is facilitated by the presence of T cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOTHERAPY
KW - THYMUS
KW - ANTIGENS
KW - FICOLL
KW - LYMPHOCYTES
KW - B cells
KW - T cells
KW - ANTIGEN presenting cells
N1 - Accession Number: 15789199; Snippe, H. 1,2; Merchant, B. 1,2; Johannessen, L. 1,2; Inman, J. K. 1,2; Source Information: Dec78, Vol. 35 Issue 6, p1009; Subject: IMMUNIZATION; Subject: IMMUNOTHERAPY; Subject: THYMUS; Subject: ANTIGENS; Subject: FICOLL; Subject: LYMPHOCYTES; Subject: B cells; Subject: T cells; Subject: ANTIGEN presenting cells; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=15789199&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1981-26542-001
AN - 1981-26542-001
AU - Berg, Lawrence
AU - Miller, S.
AU - Helmick, E.
AU - Nutting, P.
AU - Shorr, G.
T1 - Patient care and health provider attitudes in Alaska.
JF - International Journal of Social Psychiatry
JO - International Journal of Social Psychiatry
JA - Int J Soc Psychiatry
Y1 - 1978///Win 1978
VL - 24
IS - 4
SP - 276
EP - 280
CY - US
PB - Sage Publications
SN - 0020-7640
SN - 1741-2854
N1 - Accession Number: 1981-26542-001. PMID: 744713 Partial author list: First Author & Affiliation: Berg, Lawrence; Indian Health Service, Office of Research & Development, Tucson, AZ. Release Date: 19810901. Correction Date: 20130513. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Attitudes; Medical Personnel; Mental Illness (Attitudes Toward); Personnel Selection. Minor Descriptor: Community Services; Health Care Services; Mental Health Programs. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Location: US. Page Count: 5. Issue Publication Date: Win 1978.
AB - 140 Community Health Aides in Alaskan villages (half of the total number) responded to a mailed questionnaire, the Opinions About Mental Illness (OMI) Scale, which was also administered to all the other health providers (at all levels) in the state (in 12 medical facilities and 20 alcohol programs). Data were grouped with respect to geographic location, occupation, and agency type (medical facility or alcoholism program). ANOVAs were used to test independently the main effect of geographic area, occupation, and type of agency for each profile factor. No consistent pattern was seen in the professional scores within areas. A high degree of negative association was found between Authoritarianism and Social Restrictiveness and the amount of academic training. Mental Hygiene Ideology (high treatment orientation and humanitarian perspective) tended to be positively associated with academic training. Alcoholism treatment agencies scored significantly higher on Benevolence and Mental Hygiene Ideology scales. The question is raised as to whether or not these results can be used as screening devices for choice of personnel to work with consumers, but caution is urged about applying the results without outcome studies. (11 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - geographical location & occupation & agency type vs personality traits & attitudes about mental illness
KW - health providers
KW - Alaska
KW - 1978
KW - Employee Attitudes
KW - Medical Personnel
KW - Mental Illness (Attitudes Toward)
KW - Personnel Selection
KW - Community Services
KW - Health Care Services
KW - Mental Health Programs
KW - 1978
DO - 10.1177/002076407802400408
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1981-26542-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Saba, Virginia K
AU - Skapik, Kathleen A
T1 - Nursing information center
JO - American Journal of Nursing
JF - American Journal of Nursing
Y1 - 1979/01//
VL - 79
IS - 1
M3 - Article
SP - 86
EP - 87
SN - 0002936X
AB - The nursing information center is computerized information retrieval system operated by the national health planning information center. It has three major features: 1) a computerized, on/line searchable information file of abstracts of the literature on nursing services, nursing resources, and nursing planning and resources development practice and methodology; 2) a reference service that provides information responses to specific inquiries, including an annotated bibliography; and 3) access to reports of the referenced literature in paper copy and microfiche. The center also provides access to 'fugitive' literature, originally unpublished or distributed to only a very limited audience, such as doctoral dissertations, reports from federally funded projects and studies, state and local governmant and nursing association studies and plans, etc. The information base can be searched using any word or sequence of words; the information base can be searched using any word or sequence of words: the vocabulary is not limited to certain key terms. The system also provides full-text searchers for what word or word sequence, searching the title of documents, the bylines, and the abstracts. Document input into the system include journal articles, bibliographies books, and documents submitted by the division of nursing of the u.s. Public health service.
N1 - Accession Number: ISTA1402781; Saba, Virginia K 1; Skapik, Kathleen A; Affiliations: 1 : Division Of Nursing, Public Health Service, Hyattsville, Maryland; Source Info: January 1979, Vol. 79 Issue 1, p86; Note: Update Code: 1400; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA1402781&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Halperin, Jerome A.
T1 - Effects of Written Drug Information on Patient Knowledge and Compliance: A Literature Review.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/01//
VL - 69
IS - 1
M3 - Article
SP - 47
PB - American Public Health Association
SN - 00900036
AB - Abstract: The prospect of patient-oriented prescription drug labeling has focused increased attention on the effectiveness of written information for the consumer. Studies which have evaluated the effects of written prescription drug information in a patient population are reviewed. Several studies indicate that written information can be effective in improving patient compliance with regimens for antibiotic therapy. However, for drugs used on a long-term basis, written information as a sole intervention has not been shown to be sufficient for improving patient compliance. Patient knowledge of less commonly known information, such as precautions, side effects, or special directions is frequently improved by written information. Listing a drug's side effects has not been shown to increase the reported experience of side effects; however, one study suggests that patients may be more willing to report side effects to a health professional if they are listed in the written information. The trend for recent studies has been to focus on the "milieu" in which written information is provided or to systematically vary structural features of the information in order to improve the quality of drug communications. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Antibacterial agents
KW - Antibiotics
KW - Diseases -- Causes & theories of causation
KW - Drugs -- Side effects -- Reporting
KW - Drugs -- Physiological effect
KW - Patient compliance
KW - Health behavior
KW - Prospecting -- Costs
N1 - Accession Number: 6007861; Morris, Louis A. 1; Halperin, Jerome A. 2; Affiliations: 1: Technical Information Specialist (Social Sciences), Bureau of Drugs, HFD-107, Food and Drug Administration, Rockville, MD 20857.; 2: Deputy Associate Director, Bureau of Drugs, FDA.; Issue Info: Jan1979, Vol. 69 Issue 1, p47; Thesaurus Term: Anti-infective agents; Thesaurus Term: Antibacterial agents; Thesaurus Term: Antibiotics; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Drugs -- Side effects -- Reporting; Subject Term: Drugs -- Physiological effect; Subject Term: Patient compliance; Subject Term: Health behavior; Subject Term: Prospecting -- Costs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=6007861&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kennedy, D.;
T1 - Reaction of FDA to a fundamental change in the nature of regulations
CT - Reaction of FDA to a fundamental change in the nature of regulations
JO - J. Parenter. Drug Assoc.
JF - J. Parenter. Drug Assoc.
Y1 - 1979/01/01/
VL - 33
IS - Jan-Feb
SP - 17
EP - 20
AD - Food and Drug Administration, Washington, DC
N1 - Accession Number: 17-02643; Language: English; Journal Coden: JPDADK; Section Heading: Legislation, Laws and Regulations; Pharmaceutical Technology; Abstract Author: Nancy Lande
N2 - The FDA's viewpoints on the current and future changes in the regulatory policies on parenterals are presented. The effects of Good Manufacturing Practices regulations, communications between the FDA and pharmaceutical industry experts and scientific advances on the changes in the regulatory policies on quality control are discussed.
KW - Food and Drug Administration (U.S.)--regulations--injections, current and future changes, discussion;
KW - Regulations--injections--Food and Drug Administration, current and future changes, discussion;
KW - Injections--regulations--Food and Drug Administration, current and future changes, discussion;
KW - Good Manufacturing Practices--regulations--injections, effects, quality control;
KW - Control, quality--injections--industry, pharmaceutical, effects, FDA regulation changes;
KW - Communication--Food and Drug Administration (U.S.)--and industry, pharmaceutical, effects, quality control regulation changes;
KW - Communication--industry, pharmaceutical--and FDA, effects, quality control regulation changes;
KW - Industry, pharmaceutical--regulations--injections, FDA, current and future changes, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2009-05554-001
AN - 2009-05554-001
AU - Matthews, Susan M.
AU - Mosher, Loren R.
AU - Roper, Margaret T.
AU - Menn, Alma Z.
T1 - 'Non-neuroleptic treatment for schizophrenia': The authors reply.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 1979///
VL - 5
IS - 4
SP - 566
EP - 567
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Matthews, Susan M., Center for Studies of Schizophrenia National Institute of Mental Health, Rockville, MD, US, 20857
N1 - Accession Number: 2009-05554-001. Partial author list: First Author & Affiliation: Matthews, Susan M.; Center for Studies of Schizophrenia, National Institute of Mental Health, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091005. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Neuroleptic Drugs; Schizophrenia; Treatment Effectiveness Evaluation. Minor Descriptor: Psychiatric Hospital Discharge; Relapse (Disorders); Therapeutic Community. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: 1979.
AB - Responds to the comments by A. Rifkin (see record [rid]2009-05555-001[/rid]) on the current authors' original article (see record [rid]1981-13171-001[/rid]). The authors address the five major points raised by Rifkin: (1) Sample selection; (2) Criteria for rehospitalization; (3) The findings of Klein and Rosen (1973); (4) The meaning of 'purely clinical' decision; and (5) Relapse rates and selection criteria. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroleptic vs intensive psychosocial milieu treatment
KW - relapse
KW - residential care discharge
KW - first-admission schizophrenics
KW - 1979
KW - Drug Therapy
KW - Neuroleptic Drugs
KW - Schizophrenia
KW - Treatment Effectiveness Evaluation
KW - Psychiatric Hospital Discharge
KW - Relapse (Disorders)
KW - Therapeutic Community
KW - 1979
DO - 10.1093/schbul/5.4.566
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Greene, J. C.;
T1 - Dentist's role on the P&T Committee of USPHS hospitals and clinics
CT - Dentist's role on the P&T Committee of USPHS hospitals and clinics
JO - Hospital Formulary (USA)
JF - Hospital Formulary (USA)
Y1 - 1979/02/01/
VL - 14
IS - Feb
SP - 221
EP - 224
SN - 00986909
AD - US Public Health Service, Washington, DC
N1 - Accession Number: 17-02705; Language: English; Journal Coden: HOFOD9; Section Heading: Institutional Pharmacy Practice; Abstract Author: Julia A. Delaney
N2 - The increasing role of the dentist on the pharmacy and therapeutics committee of Public Health Service hospitals and clinics, and his knowledge of drugs such as analgesics, antibiotics, antihistamines, anti-inflammatory agents and fluorides which enable him to make meaningful contributions to these committees, are discussed.
KW - Dentists--role--pharmacy and therapeutics committee, PHS hospitals and clinics, discussion;
KW - Pharmacy and therapeutics committee--dentists--role, PHS hospitals and clinics, discussion;
KW - Hospitals--Public Health Service--and clinics, dentists, role, pharmacy and therapeutics committee, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - CASE
AU - Shwartz, Michael
AU - Fuchs, Michael
T1 - THE WEAPON WAS READY BUT THE TARGET MAY HAVE MOVED OR A RESOURCE ALLOCATION INDEX: A CALIFORNIA CASE STUDY.
JO - Interfaces
JF - Interfaces
Y1 - 1979/02//Feb79 Part1
VL - 9
IS - 2
M3 - Case Study
SP - 87
EP - 92
PB - INFORMS: Institute for Operations Research
SN - 00922102
AB - An index of relative need for health resources was developed to assist the California Rural Indian Health Board in allocating limited funds to rural California Indian health projects. The index was constructed by determining the relative weight of each project according to the following criteria: the current population served, the total population in the service area, the population density of the service area, the proportion of the population that lives within 30 minutes of the health facility, the distance of the health facility from the nearest urban area, and weather. A multi-step process was then used to determine weights to assign to each of the individual criteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Interfaces is the property of INFORMS: Institute for Operations Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FEASIBILITY studies
KW - HEALTH facilities
KW - PHYSICAL fitness centers
KW - MEDICAL care
KW - PUBLIC health
KW - POPULATION
KW - CITIES & towns
KW - WEATHER
KW - CALIFORNIA
N1 - Accession Number: 6689603; Shwartz, Michael 1; Fuchs, Michael 2; Affiliations: 1: School of Management, Boston University 212 Bay State Road Boston, Massachusetts 02215; 2: Special Projects Officer Indian Health Service, HEW 50 United Nations Plaza, San Francisco, California 94102; Issue Info: Feb79 Part1, Vol. 9 Issue 2, p87; Thesaurus Term: FEASIBILITY studies; Thesaurus Term: HEALTH facilities; Thesaurus Term: PHYSICAL fitness centers; Thesaurus Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: POPULATION; Subject Term: CITIES & towns; Subject Term: WEATHER; Subject: CALIFORNIA; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Case Study
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DP - EBSCOhost
DB - ent
ER -
TY - GEN
AU - Kumkumian, Charles S
T1 - Symposium on chemical utilization by fda bureau of drugs chemists: introductory remarks
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1979/02//
VL - 19
IS - 1
M3 - Article
SP - 1
EP - 1
SN - 00952338
AB - This symposium was organized to acquaint the scientific community with the manner in which bureau of drugs chemists utilize available chemical information as it pertains to the various areas in which they are involved.
N1 - Accession Number: ISTA1400822; Kumkumian, Charles S 1; Affiliations: 1 : Food And Drug Administration, Rockville, Maryland; Source Info: February 1979, Vol. 19 Issue 1, p1; Note: Update Code: 1400; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Richman, John A
T1 - Chemical information sources: aids in the review of drug applications
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1979/02//
VL - 19
IS - 1
M3 - Article
SP - 1
EP - 3
SN - 00952338
AB - Applications of computerized databases to the 'chemisths review' of drug applications are presented with emphasis on the critical topics addressed in he controls review process and the time limitations imposed thereon.
N1 - Accession Number: ISTA1400802; Richman, John A 1; Affiliations: 1 : Bureau Of Drugs, Food And Drug Administration, Rockville, Maryland; Source Info: February 1979, Vol. 19 Issue 1, p1; Note: Update Code: 1400; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Benson, Walter R
AU - Wright, William W
T1 - Chemical data: an essential tool in the regulation of drugs
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1979/02//
VL - 19
IS - 1
M3 - Article
SP - 3
EP - 8
SN - 00952338
AB - How the bureau of drugs laboratories and offices obtain chemical data from the scientific literature, from user complaints and product defect reporting systems, from the drug manufacterurers, from analyses of drug samples collected from the market, and from analytical researchh are described. The chemical data thus educed have been used successfully in developing new analytical methods, in establishing better specification of drug quality, in removing adulterated drugs from the marketplace, in successfully prosecuting purveyors of substandard drugs, and in general assuring that consumers are provided with safe and effective drugs of high quality.
N1 - Accession Number: ISTA1400811; Benson, Walter R 1; Wright, William W; Affiliations: 1 : Division Of Drug Chemistry And Pharmaceutical Research And Testing, Bureau Of Drugs, Food And Drug Administration, Washington; Source Info: February 1979, Vol. 19 Issue 1, p3; Note: Update Code: 1400; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Andrew, Mary Lou
AU - Wayland, Lola G
T1 - Sources of chemical information used in antibiotic certification
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1979/02//
VL - 19
IS - 1
M3 - Article
SP - 8
EP - 11
SN - 00952338
AB - Because of a legislative mandate requiring the predistribution testing and certification of each batch of antibiotics produced for human use in the usa, the national center for antibiotic analysis (ncaa) must utilize a wide variety of techniques for establshing its official methods. Methods adapted from meterial submitted by the manufacturers in forms 5 and 6, as well as from other sources, such as literature searches, the ncca reprint collection, and cross reference file are described.
N1 - Accession Number: ISTA1400810; Andrew, Mary Lou 1; Wayland, Lola G; Affiliations: 1 : Food And Drug Administration, Washington; Source Info: February 1979, Vol. 19 Issue 1, p8; Note: Update Code: 1400; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Solkot, Roy
T1 - The development and compilation of chemical information by the bureau of drugs medical library for the drug review process
JO - Journal of Chemical Information & Computer Sciences
JF - Journal of Chemical Information & Computer Sciences
Y1 - 1979/02//
VL - 19
IS - 1
M3 - Article
SP - 11
EP - 13
SN - 00952338
AB - Supportive integration into fda's drug review process of literature surveys of biochemical and biomedical material published worldwide may take place at any stage in the progress of the review. Technical information specialists on the library staff utilize printed abstracts/index sources as well as computer terminals on the library premises to access at least 37 unique databases. Pertinence embraces numerous fields (pharmacology, toxicology, agriculture, biology, chemistry, food technology, human and veterinary medicine, patents, pesticides, pollution, and psychology), general scientific data, and both completed and projected or ongoing us government-sponsored research.
N1 - Accession Number: ISTA1400831; Solkot, Roy 1; Affiliations: 1 : Bureau Of Drugs, Food And Drug Administration, Rockville, Maryland; Source Info: February 1979, Vol. 19 Issue 1, p11; Note: Update Code: 1400; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Pitha, Josef
AU - Kociolek, Karol
AU - Caron, Marc G.
T1 - Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/02/15/
VL - 94
IS - 1
M3 - Article
SP - 11
EP - 18
SN - 00142956
AB - Residues of Triton X-100 [C8H17-C6H4-(O-CH2-CH2)9-10-O-] were bound by ether bonds to inulin, dextran, amylose, and cellulose-yielding compounds containing 10- 30, 5, 19 and 6% (w/w) of Triton X-100 residue respectively. The water-soluble inulin derivative was studied in detail. This compound was fractionated on the basis of molecular weight by gel chromatography and on the basis of degree of substitution by adsorption to polystyrene resin. Even the residues of Triton X-100 which were bound to a single inulin macromolecule were able to form a micelle; in addition to these monomolecular micelles the inulin derivative was able to form polymolecular micelles as well. The inulin derivative was effective in solubilizing proteins and phospholipids from membranes of human erythrocytes and liberated reverse transcriptase activity from the membrane-enveloped virions of murine leukemia. The Triton X-100 inulin derivative abolished binding of the ³H-labelled antagonist dihydroalprenolol to solubilized preparations of β-adrenergic receptors from frog erythrocytes in a dose-related manner similar to the inactivation produced by Triton X-100, while digitonin, a detergent containing a bulkier hydrophobic group, did not cause inactivation. On the basis of its Triton X-100 content, the inulin derivative was found to be less detrimental to the growth of murine erythroleukemic cells in vitro than Triton X-100 alone when short (2-4 h) exposures were used, but this difference disappeared at longer (1-3 day) exposures. Results thus suggest that the increase in size of the hydrophilic part of the detergent brings about moderation in those effects of the detergent which are dependent on the rate of diffusion, while the solubilizing and inactivating effects of the detergent were not changed. It is probably the size of the hydrophobic part which is important in protein-inactivating properties of the detergent. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - CARBOHYDRATES
KW - LEUKEMIA
KW - CLEANING compounds -- Labeling
KW - PROTEINS
KW - CANCER
N1 - Accession Number: 13605068; Pitha, Josef 1; Kociolek, Karol 2; Caron, Marc G. 3; Source Information: 2/15/79, Vol. 94 Issue 1, p11; Subject: POLYSACCHARIDES; Subject: CARBOHYDRATES; Subject: LEUKEMIA; Subject: CLEANING compounds -- Labeling; Subject: PROTEINS; Subject: CANCER; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Middaugh, John P.
T1 - Side Effects of Diptheria-Tetanus Toxoid in Adults .
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/03//
VL - 69
IS - 3
M3 - Article
SP - 246
PB - American Public Health Association
SN - 00900036
AB - Abstract: During a mass diphtheria-tetanus immunization campaign in November 1975, more than 220,000 doses of diphtheria-tetanus toxoid, adult type were administered to adults throughout Alaska. In Anchorage, where more than 87,000 doses were given, a survey was conducted to determine the frequency of side effects. Postcard questionnaires were mailed to 2,000 randomly selected Anchorage residents: 467 questionnaires were returned by the post office as undeliverable, and 697 questionnaires were completed and returned. A follow-up survey was done of a random sample of the 836 non-responders. Of those responding, 57.8 per cent reported at least one reaction to the toxoids. The most frequent side effects were sore arm (42.7 per cent), swelling at the site of injection (34.8 per cent), and itching (24.2 per cent). Serious side effects occurred less frequently--swelling of the arm below the elbow (1.1 per cent) and abscess or infection (0.7 per cent). Of those vaccinated, 0.5 per cent saw a physician. There were no statistically significant differences in reaction rates by age group, except for sore arms. The jet injector produced more arm swelling at the site of injection, hives, and itching. More women than men reported adverse reactions, especially sore arm, swelling at the site of injection, and itching. Fear of adverse side effects should not preclude mass vaccination of adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Immunization
KW - Tetanus
KW - Diphtheria
KW - Corynebacterium diseases
KW - Drugs -- Side effects
KW - Questionnaires
KW - Surveys
KW - Alaska
KW - United States
N1 - Accession Number: 6005908; Middaugh, John P. 1; Affiliations: 1: Field Services Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, DHEW, Atlanta GA 30333; Issue Info: Mar1979, Vol. 69 Issue 3, p246; Thesaurus Term: VACCINATION; Thesaurus Term: Immunization; Subject Term: Tetanus; Subject Term: Diphtheria; Subject Term: Corynebacterium diseases; Subject Term: Drugs -- Side effects; Subject Term: Questionnaires; Subject Term: Surveys; Subject: Alaska; Subject: United States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Rate, R. G.;
AU - Leche, J.;
AU - Chervenak, C.;
T1 - Podophyllin toxicity
CT - Podophyllin toxicity
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1979/04/01/
VL - 90
IS - Apr
SP - 723
SN - 00034819
AD - U. S. Public Health Service, Keams Canyon, AZ 86034
N1 - Accession Number: 17-00245; Language: English; Trade Name: Podophyllin resin; Generic Name: Podophyllum resin; Chemical Name: Podophyllum resin--9000-55-9; Therapeutic Class: (84:00); AHFS Class: Topical preparations podophyllum resin; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Elvira deC. Weiss
N2 - Reported is a case of 20-yr-old woman who developed bone marrow suppression and severe motor/sensory peripheral neuropathy after receiving local podophyllin (podophyllum; I) treatment for a large perineal condyloma acuminata. The calculated dosage of podophyllotoxin (II) the patient received was about 150 mg total dose (about 3 ml was applied topically), or about 100 mg/sq m. The use of I in the treatment of large condyloma acuminata must be questioned since the therapeutic index of II is so narrow.
KW - Podophyllum resin--toxicity-;
KW - Podophyllotoxin--dosage-;
KW - Toxicity--podophyllum resin--bone marrow suppression, peripheral neuropathy, after topical application, condyloma acuminata patient;
KW - Topical preparations--podophyllum resin--toxicity, bone marrow suppression, and peripheral neuropathy, condyloma acuminata patient;
KW - Dosage--podophyllotoxin--high, topical application, toxicity, condyloma acuminata patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bargo, E.;
T1 - GLC determination of trihexyphenidyl hydrochloride dosage forms
CT - GLC determination of trihexyphenidyl hydrochloride dosage forms
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1979/04/01/
VL - 68
IS - Apr
SP - 503
EP - 505
SN - 00223549
AD - U.S. Food and Drug Administration, Baltimore District, Baltimore, MD 21201
N1 - Accession Number: 19-01350; Language: English; Trade Name: Artane; Generic Name: Trihexyphenidyl hydrochloride; Chemical Name: Trihexyphenidyl hydrochloride--52-49-3; Therapeutic Class: (12:08.04); AHFS Class: Antiparkinson agents trihexyphenidyl hydrochloride; References: 21; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: Paul R. Webster
N2 - A GLC method for the quantitation of trihexyphenidyl HCl (Artane; I) in various pharmaceutical dosage forms is described. The procedure involves chloroform extraction of the active ingredient from a weakly acidic solution, followed by GLC using a 3% methyl silicone column. Assay of elixirs, tablets and sustained-release capsules gave results of 95.2-105.5% of labeled I, compared to compendial methods which showed a range of 84.6-111.0%.
KW - Trihexyphenidyl hydrochloride--chromatography, gas-;
KW - Chromatography, gas--trihexyphenidyl hydrochloride--dosage forms, comparison, compendial methods;
KW - Antiparkinson agents--trihexyphenidyl hydrochloride--chromatography, gas, comparison, compendial methods, dosage forms;
KW - Tablets--trihexyphenidyl hydrochloride--chromatography, gas, comparison, compendial methods;
KW - Sustained-action medications--trihexyphenidyl hydrochloride--chromatography, gas, comparison, compendial methods, capsules;
KW - Elixirs--trihexyphenidyl hydrochloride--chromatography, gas, comparison, compendial methods;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Loeb, Gerald E.
T1 - LETTER.
JO - Scientific American
JF - Scientific American
Y1 - 1979/04//
VL - 240
IS - 4
M3 - Letter
SP - 10
EP - 10
SN - 00368733
AB - A letter to the editor is presented in response to the article "The Coupled Motions of Piano Strings," by Gabriel Weinreich in the January 1979 issue.
KW - Letters to the editor
KW - Weinreich, Gabriel
N1 - Accession Number: 20097144; Loeb, Gerald E. 1; Affiliations: 1: Laboratory of Neural Control National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health, U.S. Public Health Service, Department of Health, Education and Welfare Bethesda, Md.; Issue Info: Apr79, Vol. 240 Issue 4, p10; Subject Term: Letters to the editor; People: Weinreich, Gabriel; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FINKEL, MARION J.
T1 - Phenformin Ban.
JO - Science
JF - Science
Y1 - 1979/04/20/
VL - 204
IS - 4390
M3 - Article
SP - 242
EP - 242
SN - 00368075
N1 - Accession Number: 85199713; FINKEL, MARION J. 1; Affiliations: 1: Bureau of Drugs, Food and Drug Administration, Rockville, Maryland 20857; Issue Info: 4/20/1979, Vol. 204 Issue 4390, p242; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Dodds, A.;
AU - Archambault, G. F.;
T1 - Medicines in medical care\M/clinical pharmacist's role
CT - Medicines in medical care\M/clinical pharmacist's role
JO - Drug Intell. Clin. Pharm.
JF - Drug Intell. Clin. Pharm.
Y1 - 1979/05/01/
VL - 13
IS - May
SP - 290
EP - 292
AD - Pharm. Branch, FHPS, HSMHA, U.S. Public Health Service, Dept. of HEW, Washington, DC
N1 - Accession Number: 17-01867; Language: English; References: 1; Journal Coden: DICPBB; Section Heading: Pharmacy Practice; Abstract Author: Paul R. Webster
N2 - Results of a survey depicting the attitudes and opinions of 283 pharmacists and 263 physicians toward clinical pharmacy services are presented.
KW - Clinical pharmacy--services--survey, pharmacist and physician attitudes;
KW - Pharmacists--attitudes--clinical pharmacy, services, survey;
KW - Physicians--attitudes--clinical pharmacy, services, survey;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 2006-06574-059
AN - 2006-06574-059
AU - Nachmann, Barbara
T1 - How Long, How Long?
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1979/05//
VL - 24
IS - 5
SP - 426
EP - 427
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06574-059. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Nachmann, Barbara; U.S. Public Health Service, Division of Indian Health, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Brief Psychotherapy; Cognitive Therapy; Psychotherapeutic Techniques; Therapists. Minor Descriptor: Motivation. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Reviewed Item: Davanloo, Habib (Ed). Basic Principles and Techniques in Short-Term Dynamic Psychotherapy=New York: SP Medical & Scientific Books, 1978. Pp. 555. $30.00; 1978. Page Count: 2. Issue Publication Date: May, 1979.
AB - Reviews the book, Basic Principles and Techniques in Short-Term Dynamic Psychotherapy edited by Habib Davanloo (1978). The book suffers the structural handicap of multiple authorship and of being part book, part symposium. All three major contributors emphasize the same criteria for the selection of candidates for short-term therapy: a circumscribed chief complaint, a history of one meaningful relationship during early life, flexible access to feelings, above-average intelligence, psychological sophistication, and high motivation for change. The discussion of therapist variables includes the intriguing suggestion that what accounts for the occasional finding that inexperienced therapists may do as well as experienced ones is the enthusiasm that grips anyone at, the start of a new venture. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - basic principles
KW - techniques
KW - short term dynamic psychotherapy
KW - therapist variables
KW - 1979
KW - Brief Psychotherapy
KW - Cognitive Therapy
KW - Psychotherapeutic Techniques
KW - Therapists
KW - Motivation
KW - 1979
U2 - Davanloo, Habib (Ed). (1978); Basic Principles and Techniques in Short-Term Dynamic Psychotherapy; New York: SP Medical & Scientific Books, 1978. Pp. 555. $30.00
DO - 10.1037/019037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06574-059&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 83995257
T1 - A trial of minocycline given after exposure to prevent gonorrhea.
AU - Harrison, William O.
AU - Hooper, Richard R.
AU - Wiesner, Paul J.
AU - Campbell, Axel F.
AU - Karney, Walter W.
AU - Reynolds, Gladys H.
AU - Jones, Oscar G.
AU - Holmes, King K.
AU - Harrison, W O
AU - Hooper, R R
AU - Wiesner, P J
AU - Campbell, A F
AU - Karney, W W
AU - Reynolds, G H
AU - Jones, O G
AU - Holmes, K K
Y1 - 1979/05/10/
N1 - Accession Number: 83995257. Language: English. Entry Date: In Process. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Gonorrhea -- Prevention and Control
KW - Medicine
KW - Tetracyclines -- Therapeutic Use
KW - Minocycline -- Therapeutic Use
KW - Time Factors
KW - Neisseria -- Drug Effects
KW - United States
KW - Gonorrhea -- Drug Therapy
KW - Human
KW - Drug Resistance, Microbial
KW - Urethritis -- Etiology
KW - Administration, Oral
KW - Coitus
KW - Minocycline -- Adverse Effects
KW - Tetracycline -- Pharmacodynamics
KW - Minocycline -- Administration and Dosage
KW - Male
KW - Far East
KW - Urethritis -- Prevention and Control
KW - Minocycline -- Pharmacodynamics
KW - Drug Evaluation
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Randomized Controlled Trials
SP - 1074
EP - 1078
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 300
IS - 19
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
AB - In a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline or placebo after sexual intercourse with prostitutes in a Far Eastern port. Later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given minocycline (P less than 0.001). Minocycline prophylaxis completely prevented infection by gonococci susceptible to 0.75 microgram or less of tetracycline per milliliter, reduced the risk of infection or prolonged the incubation period in men exposed to gonococci susceptible to 1.0 to 2.0 micrograms per milliliter, but did not prevent infection or prolong incubation in men exposed to gonococci resistant to 2.0 micrograms. Minocycline did not increase the proportion of asymptomatic infections. Minocycline prophylaxis would probably have limited effectiveness as a public-health measure because of the tendency to select resistant gonococci.
SN - 0028-4793
AD - From the Infectious Disease Division, Naval Regional Medical Center, San Diego; Navy Environmental and Preventive Medicine Units No. Five (San Diego) and Six (Pearl Harbor); the Venereal Disease Control Division, Bureau of State Services, Center for Disease Control, Atlanta; and the Department of Medicine, U.S. Public Health Service Hospital and the University of Washington, Seattle (address reprint requests to Dr. Holmes at the U.S. Public Health Service Hospital, 1131 14th Ave. S., Seattle, WA 98114).
U2 - PMID: 107450.
DO - 10.1056/NEJM197905103001903
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Harrison, W. O.;
AU - Hooper, R. R.;
AU - Wiesner, P. J.;
AU - Campbell, A. F.;
AU - Holmes, K. J.;
AU - \ET/;
T1 - Trial of minocycline given after exposure to prevent gonorrhea
CT - Trial of minocycline given after exposure to prevent gonorrhea
JO - New England Journal of Medicine (USA)
JF - New England Journal of Medicine (USA)
Y1 - 1979/05/10/
VL - 300
IS - May 10
SP - 1074
EP - 1078
SN - 00284793
AD - U.S. Public Health Service Hosp., 1131 14th Ave. S., Seattle, WA 98114
N1 - Accession Number: 16-4843; Language: English; Chemical Name: Minocycline--10118-90-8; References: 12; Journal Coden: NEJMAG; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - In a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline (I) or placebo after sexual intercourse with prostitutes in a Far Eastern port. Later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given I. I prophylaxis completely prevented infection by gonococci susceptible to 0.75 \mu/g or less of tetracycLine/ml, reduced the risk of infection or prolonged the incubation period in men exposed to gonococci susceptible to 1.0 to 2.0 \mu/g/ml, but did not prevent infection or prolong incubation in men exposed to gonococci resistant to 2.0 \mu/g. I did not increase the proportion of asymptomatic infections. I prophylaxis would probably have limited effectiveness as a public health measure because of the tendency to select resistant gonococci.
KW - Minocycline--gonorrhea-;
KW - Rational therapy--minocycline--gonorrhea, prophylaxis, lack, effects, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Colligan, Michael J.
AU - Murphy, Lawrence R.
T1 - Mass psychogenic illness in organizations: An overview.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1979/06//
VL - 52
IS - 2
M3 - Article
SP - 77
EP - 90
PB - Wiley-Blackwell
SN - 03058107
AB - Published and unpublished reports of mass psychogenic illness, defined as the collective occurrence of physical symptoms and related beliefs among two or more persons in the absence of an identifiable pathogen, are reviewed with particular emphasis on organizational occurrences. A number of factors (e.g. boredom, sex-role identification, interpersonal conflict, physical stress) are identified as potential precipitating conditions, and the contagion of symptoms is discussed in terms of the convergence-contagion dichotomy in collective behaviour suggested by Milgram & Toch (1969). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL illness
KW - MENTAL fatigue
KW - CONFLICT (Psychology)
KW - SOCIAL psychology
KW - INTERPERSONAL conflict
KW - COLLECTIVE behavior
N1 - Accession Number: 6293742; Colligan, Michael J. 1; Murphy, Lawrence R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, US Department of Health, Education and Welfare.; Issue Info: Jun79, Vol. 52 Issue 2, p77; Subject Term: MENTAL illness; Subject Term: MENTAL fatigue; Subject Term: CONFLICT (Psychology); Subject Term: SOCIAL psychology; Subject Term: INTERPERSONAL conflict; Subject Term: COLLECTIVE behavior; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Shosteck, Herschel
AU - Fairweather, William R.
T1 - Physician Response Rates to Mail and Personal Interview Surveys.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1979///Summer79
VL - 43
IS - 2
M3 - Article
SP - 206
PB - Oxford University Press / USA
SN - 0033362X
AB - Presents an experiment conducted by the U.S. Food and Drug Administration which compares the mail and personal administration survey on physician antibiotic prescription practices. Advantages of mail surveys; Design of the experiment; Focus of the study towards the office based physicians.
KW - Questionnaires
KW - Mail surveys
N1 - Accession Number: 5414291; Shosteck, Herschel 1; Fairweather, William R. 2; Affiliations: 1: President of Herschel Shosteck Associates, Silver Spring, Maryland, Director of Survey Research and Evaluation for Data Transformation Corporation, and a member of the adjunct faculty of the University of Maryland.; 2: Group Leader in the Statistical Evaluation Branch, Division of Biometrics, Bureau of Drugs of the U.S. Food and Drug Administration.; Issue Info: Summer79, Vol. 43 Issue 2, p206; Thesaurus Term: Questionnaires; Subject Term: Mail surveys; Number of Pages: 12p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Wardlaw, A. C.
AU - Parton, R.
AU - Bergman, R. K.
AU - Munoz, J. J.
T1 - Loss of adjuvanticity in rats for the hyperacute form of allergic encephalomyelitis and for reaginic antibody production in mice of a phenotypic variant of Bordetella pertussis .
JO - Immunology
JF - Immunology
Y1 - 1979/07//
VL - 37
IS - 3
M3 - Article
SP - 539
EP - 545
SN - 00192805
AB - The adjuvanticity of a phenotypic (C-mode) variant of B. pertussis, known to be deficient in certain immunological and physiopathological properties, was compared to that of the normal (X-mode) strain. The X-mode vaccine was a potent adjuvant for induction of hyperacute experimental allergic encephalomyelitis to guinea-pig spinal cord in Lewis rats whereas C-mode vaccine was inactive. X-mode vaccine was also highly active in the induction of reaginic (both IgE and IgG1) antibodies to ovalbumin in mice while C-mode vaccine caused only a transitory increase in the IgE level. These data support the view that an adjuvant component of B. pertussis, which is probably identical with the histamine-sensitizing and leukocytosis promoting factor, is much diminished in C-mode cells while the lipopolysaccharide adjuvant remains unchanged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGICAL adjuvants
KW - BIOLOGICAL response modifiers
KW - PREVENTIVE medicine
KW - IMMUNOGLOBULINS
KW - BORDETELLA pertussis
KW - ALLERGIC encephalomyelitis
KW - AUTOIMMUNE diseases
N1 - Accession Number: 13988628; Wardlaw, A. C. 1; Parton, R. 1; Bergman, R. K. 2; Munoz, J. J. 1; Source Information: Jul79, Vol. 37 Issue 3, p539; Subject: IMMUNOLOGICAL adjuvants; Subject: BIOLOGICAL response modifiers; Subject: PREVENTIVE medicine; Subject: IMMUNOGLOBULINS; Subject: BORDETELLA pertussis; Subject: ALLERGIC encephalomyelitis; Subject: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Donohue, Joseph C.
T1 - The Library of Congress: A Proposed Role in a National Information and Referral Network.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1979/07//
VL - 30
IS - 4
M3 - Article
SP - 202
EP - 204
SN - 00028231
AB - Information and referral (I&R) services provide needed communication between citizens and agencies that serve them. There is need for coordination of general and specialized I&R services into a national network to improve effectiveness and economy, as recommended by a recent report of the U.S. Comptroller General. The Library of Congress should coordinate the federal resources being spent for I&R, in much the same way as it does library services to the physically handicapped. Placement of this function in the legislative branch could assure greater continuity of support and responsiveness to the citizen and in turn could provide a stronger bond between legislators and their constituencies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIBRARIES
KW - INFORMATION resources
KW - INFORMATION storage & retrieval systems
KW - INFORMATION resources management
KW - INFORMATION science
KW - LEGISLATORS
N1 - Accession Number: 17236084; Donohue, Joseph C. 1; Affiliations: 1: Food and Drug Administration, HFF-36,200 C Street, S. W., Washington, DC 20204.; Issue Info: Jul1979, Vol. 30 Issue 4, p202; Thesaurus Term: LIBRARIES; Thesaurus Term: INFORMATION resources; Thesaurus Term: INFORMATION storage & retrieval systems; Thesaurus Term: INFORMATION resources management; Thesaurus Term: INFORMATION science; Subject Term: LEGISLATORS; NAICS/Industry Codes: 519190 All Other Information Services; NAICS/Industry Codes: 519121 Libraries; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519120 Libraries and Archives; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Gleser, M
AU - Woods, D
T1 - A database built upon the medical event vector
JO - Methods of Information in Medicine
JF - Methods of Information in Medicine
Y1 - 1979/07//
VL - 18
IS - 3
M3 - Article
SP - 131
EP - 137
SN - 00261270
AB - Phamis is an automated medical information system designed to provide long-term storage and retrieval of clinical information about public health service patients. The patient data base is composed of clinical events stored in compact format as multi-dismensional vectors in a write-once, read-only file to minimize file maintenance. Clinical observations are recorded as pointers to a large and expandable dictionary, rather than as text, to reduce storage reequirements. The database design includes both eithinpatient-record and between-patient-record indexes to speed data retrieval and facilitate report generation.
N1 - Accession Number: ISTA1401452; Gleser, M 1; Woods, D; Affiliations: 1 : Department Of Health Services Research, U.s. Public Health Service Hospital, Seattle, Washington; Source Info: July 1979, Vol. 18 Issue 3, p131; Note: Update Code: 1400; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Daugharty, H.
AU - Kelley, K.
AU - Moore, C.
AU - Hersh, T.
T1 - Autoimmune implications of immune complexes in clinical variants of hepatitis B.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/08//
VL - 37
IS - 2
M3 - Article
SP - 213
EP - 220
SN - 00099104
AB - Immune complexes (IC) were investigated in sera from 208 individuals with various clinical types of viral hepatitis diagnosed by clinical and laboratory criteria, including liver biopsy. Immune complexes were assessed by platelet aggregation (P1 A) and by radioimmunoassay (RIA). The data were related to autoimmune phenomena (especially rheumatoid factors) and to the role that the IgM class to hepatitis B (HB) antibody might have in IC formation. Although the highest frequency of PI A was in the few sera from patients with cirrhosis or hepatoma, the next highest was in sera from acute hepatitis patients (71%), and the lowest in sera from chronic active (57%) and chronic persistent (46%) hepatitis patients. A proportional number of patients with IC's were positive for hepatitis B surface antigen (HBs). A parallel prevalence was noted between PI A and autoantibodies, with anti-Ig's being found more frequently in sera from acute hepatitis and chronic active hepatitis patients. The relationship between RIA results for complexes and RIA results for anti-IgG was inverse, as though anti-IgG interfered with IC reactivity by RIA. Anti-lgM pre-incubated with sera increased the amount of PI A in sera from patients with acute hepatitis as well as in those from patients with chronic persistent hepatitis, suggesting a more frequent IgM involvement in IC's in these diseases than in chronic active hepatitis. Whereas liver cell damage in acute and active hepatitis may reflect elevated autoantibodies, the IgM class of HBs antibody may be involved in acute as well as chronic persistent hepatitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B
KW - AUTOIMMUNE diseases
KW - IMMUNE complexes
KW - RADIOIMMUNOASSAY
KW - CHRONIC active hepatitis
KW - AUTOANTIBODIES
N1 - Accession Number: 16434598; Daugharty, H. 1; Kelley, K. 1; Moore, C. 2; Hersh, T. 2; Source Information: Aug1979, Vol. 37 Issue 2, p213; Subject: HEPATITIS B; Subject: AUTOIMMUNE diseases; Subject: IMMUNE complexes; Subject: RADIOIMMUNOASSAY; Subject: CHRONIC active hepatitis; Subject: AUTOANTIBODIES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Curtin, Lester R.
AU - Frockt, I. Joel
AU - Koch, Gary G.
T1 - A NOTE ON THE ANALYSIS OF PARITY PROGRESSION RATIOS.
JO - Demography
JF - Demography
Y1 - 1979/08//
VL - 16
IS - 3
M3 - Article
SP - 481
EP - 484
SN - 00703370
AB - The article focuses on effects of independent variables on parity progression ratios. A parity-specific measure of interest in the analysis of fertility is the probability of making a transition from one parity to the next. The study of this transition encompasses the idea of fertility as a sequential decision-making process. In most analytical procedures, each parity or parity transition is considered separately. A more unified approach is to apply contingency table modeling procedures to "smooth" the transition probabilities across parity and between different groups in a population. This note indicates how weighted least squares fitting procedures can be used to smooth and analyze the transition probabilities in the form of parity progression ratios computed from data on the number of children ever born.
KW - PROBABILITY theory
KW - DECISION making
KW - ESTIMATION theory
KW - FERTILITY
KW - REPRODUCTION
KW - CONTINGENCY tables
KW - CURVE fitting
N1 - Accession Number: 16799317; Curtin, Lester R. 1; Frockt, I. Joel 2; Koch, Gary G. 3; Affiliations: 1: National Center for Health Statistics, HyattsvilIe, Maryland 20782.; 2: National institute for Occupational Safety and Health, Robert A. Taft Laboratory, Cincinnati, Ohio 45226.; 3: School of Public Health, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.; Issue Info: Aug1979, Vol. 16 Issue 3, p481; Thesaurus Term: PROBABILITY theory; Thesaurus Term: DECISION making; Thesaurus Term: ESTIMATION theory; Subject Term: FERTILITY; Subject Term: REPRODUCTION; Subject Term: CONTINGENCY tables; Subject Term: CURVE fitting; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - KACHADORIAN, WILLIAM A.
AU - MULLER, JACQUELINE
AU - RUDICH, STEPHEN W.
AU - DISCALA, VINCENT A.
T1 - Temperature Dependence of ADH-Induced Water Flow and Intramembranous Particle Aggregates in Toad Bladder.
JO - Science
JF - Science
Y1 - 1979/08/31/
VL - 205
IS - 4409
M3 - Article
SP - 910
EP - 913
SN - 00368075
AB - Antidiuretic hormone (ADH) -induced luminal intramembranous partic le aggregates and hormonally stimulated wtater flowv in toad urinary bladder are reduced simultaneously with a reduiction in temperature. When water movement is factored by the aggregation response, the apparent activation energy for this process decreases from 12.1 ± 1.6 to 3.0 ± 2.3 kilocalories per mole. The data are consistent with the view that the particle aggregates contain sites for transmembrane water movement and that these sites behave as pores. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85269156; KACHADORIAN, WILLIAM A. 1; MULLER, JACQUELINE 1; RUDICH, STEPHEN W. 1; DISCALA, VINCENT A. 1; Affiliations: 1: Membrane Research Laboratory, Renal Service, U.S. Public Health Service Hospital, Staten Island, New York 10304; Issue Info: 8/31/1979, Vol. 205 Issue 4409, p910; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FAJEN, J. M.
AU - CARSON, G. A.
AU - ROUNBEHLER, D. P.
AU - FAN, T. Y.
AU - VITA, R.
AU - GOFF, U. E.
AU - WOLF, M. H.
AU - EDWARDS, G. S.
AU - FINE, D. H.
AU - REINHOLD, V.
AU - BIEMANN, K.
T1 - N-Nitrosamines in the Rubber and Tire Industry.
JO - Science
JF - Science
Y1 - 1979/09/21/
VL - 205
IS - 4412
M3 - Article
SP - 1262
EP - 1264
SN - 00368075
AB - Airborne N-nitrosomorpholine (O to 27 mic rograms per cubic meter) was found in two of four rubber industry factories. N-Nitrosodimethylamine was also found in two factories, but at lower levels. These findings may be relevant to the reported increased risk of certain types of cancer in rubber workers in solnc of the same areas where the N-nitrosomorpholine levels were highest. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85195862; FAJEN, J. M. 1; CARSON, G. A. 1; ROUNBEHLER, D. P. 2; FAN, T. Y. 2; VITA, R. 2; GOFF, U. E. 2; WOLF, M. H. 2; EDWARDS, G. S. 2; FINE, D. H. 2; REINHOLD, V. 3; BIEMANN, K. 3; Affiliations: 1: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226; 2: New England Institute for Life Sciences, Waltham, Massachusetts 02154; 3: Chemistry Department, Massachusetts Institute of Technology Cambridge 02139; Issue Info: 9/21/1979, Vol. 205 Issue 4412, p1262; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROBBINS, ANTHONY
T1 - Dioxin Studies.
JO - Science
JF - Science
Y1 - 1979/09/28/
VL - 205
IS - 4413
M3 - Article
SP - 1332
EP - 1332
SN - 00368075
N1 - Accession Number: 85269217; ROBBINS, ANTHONY 1; Affiliations: 1: Office of the Director, National Institute for Occupational Safety and Health, 5600 Fishers Lane, Rockville, Maryland 20857; Issue Info: 9/28/1979, Vol. 205 Issue 4413, p1332; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hagebak, Beaumont R.
T1 - LOCAL HUMAN SERVICE DELIVERY: THE INTEGRATION IMPERATIVE.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1979/11//Nov/Dec79
VL - 39
IS - 6
M3 - Article
SP - 575
PB - Wiley-Blackwell
SN - 00333352
AB - The confusing array of costly and duplicative human services apparent at the federal, state, and local levels presents a fragmented and ineffective approach to meeting human needs. Logic demands more fully integrated service delivery systems. Increasingly, political reality and even the changing self-interest of agency bureaucrats have moved decision makers at all levels to support the integration imperative and expand interagency linkages. Powerful barriers, organizational systems designed to assure vertical top-down authorities, personal and individually-held attitudes, and limited vision-all arising from self-interest needs more appropriate in an earlier day, continue to threaten the development of integrated service systems. These barriers are particularly evident at the federal and state levels, where special interest groups continue to exercise a powerful influence on the political process. Together, many different models, all meeting the unique needs of their own communities for a more rational human services structure, may illustrate that the most appropriate function of federal and state policy makers is simply to provide the flexibility and support necessary to permit those actually delivering services to get the job done.
KW - HUMAN services
KW - FEDERAL government
KW - STATE governments
KW - CIVIL service
KW - LOCAL government
KW - HUMAN services personnel
KW - UTILIZATION
KW - PRESSURE groups
KW - UNITED States
N1 - Accession Number: 4601616; Hagebak, Beaumont R. 1; Affiliations: 1: U.S. Public Health Service.; Issue Info: Nov/Dec79, Vol. 39 Issue 6, p575; Thesaurus Term: HUMAN services; Thesaurus Term: FEDERAL government; Thesaurus Term: STATE governments; Thesaurus Term: CIVIL service; Thesaurus Term: LOCAL government; Thesaurus Term: HUMAN services personnel; Subject Term: UTILIZATION; Subject Term: PRESSURE groups; Subject: UNITED States; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 813319 Other Social Advocacy Organizations; NAICS/Industry Codes: 813312 Environment, Conservation and Wildlife Organizations; NAICS/Industry Codes: 813310 Social advocacy organizations; NAICS/Industry Codes: 813311 Human Rights Organizations; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4601616&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1981-03608-001
AN - 1981-03608-001
AU - Samuels, Jeffrey A.
AU - Benson, D. Frank
T1 - Some aspects of language comprehension in anterior aphasia.
JF - Brain and Language
JO - Brain and Language
JA - Brain Lang
Y1 - 1979/11//
VL - 8
IS - 3
SP - 275
EP - 286
CY - Netherlands
PB - Elsevier Science
SN - 0093-934X
N1 - Accession Number: 1981-03608-001. PMID: 509199 Partial author list: First Author & Affiliation: Samuels, Jeffrey A.; US Public Health Service Hosp, San Francisco, CA. Release Date: 19810201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aphasia; Semantics; Sentence Comprehension; Stimulus Presentation Methods; Syntax. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Page Count: 12. Issue Publication Date: Nov, 1979.
AB - Evaluated the competency of language comprehension in 12 anterior aphasics (mean age 48.9 yrs), 6 posterior aphasics (mean age 50.8 yrs), and 5 normal controls (mean age 52 yrs). Test material was divided into 2 sentence groups (fill in the blank and true and false) emphasizing either semantic, 'real world' identity words or syntactic, relational words, and 1 paragraph interpretation task. Matching auditory and visual (written) presentations were given. Control Ss performed almost flawlessly but many errors were made by each aphasia group. The anterior aphasic group performed well on semantically weighted sentences but made errors on syntactically weighted material, regardless of mode of presentation. In contrast, the posterior aphasics made almost the same number of errors on both types of material, regardless of mode of presentation. Findings support the concept of defective language comprehension in anterior aphasia and suggest that the defect centers on the syntactical structures that are also poorly handled in expressive output. (17 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - syntactic vs semantic material & auditory vs visual presentation
KW - language comprehension
KW - anterior vs posterior aphasics
KW - 1979
KW - Aphasia
KW - Semantics
KW - Sentence Comprehension
KW - Stimulus Presentation Methods
KW - Syntax
KW - 1979
DO - 10.1016/0093-934X(79)90056-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1981-03608-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Falk, H.;
AU - Thomas, L. B.;
AU - Popper, H.;
AU - Ishak, K. G.;
T1 - Hepatic angiosarcoma associated with androgenic anabolic steroids
CT - Hepatic angiosarcoma associated with androgenic anabolic steroids
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1979/11/24/
VL - 2
IS - Nov 24
SP - 1120
EP - 1122
SN - 00237507
AD - Chronic Diseases Div., Bureau of Epidemiology, Cent. for Disease Control, Public Health Service, Dept. of HEW, Atlanta, GA 30333
N1 - Accession Number: 17-01336; Language: English; Trade Name: Delatestryl--Halotestin--Winstrol--Gynetone; Generic Name: Testosterone enanthate; Fluoxymesterone; Stanozolol; Ethinyl estradiol; Chemical Name: Testosterone enanthate--315-37-7 Fluoxymesterone--76-43-7 Methandrostenolone--72-63-9 Stanozolol--10418-03-8 Methyltestosterone--58-18-4 Ethinyl estradiol--57-63-6; References: 20; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Toxicity; Investigational Drugs
N2 - A retrospective epidemiological study of deaths from hepatic angiosarcoma in the U.S. showed that during 1964 to 1974 there were 168 such cases, of which 37 were associated with previously known causes and 4 were associated with the use of long term androgenic anabolic steroids (I) including testosterone enanthate (Delatestryl), fluoxymesterone, stanozolol (Winstrol) and methyltestosterone plus ethinyl estradiol (Gynetone). The 4 case histories associated with I are presented. It was suggested that I may be a possible cause of hepatic angiosarcoma.
KW - Testosterone enanthate--toxicity-;
KW - Fluoxymesterone--toxicity-;
KW - Methandrostenolone--toxicity-;
KW - Stanozolol--toxicity-;
KW - Methyltestosterone--alone and with ethinyl estradiol-;
KW - Ethinyl estradiol--combination, methyltestosterone-;
KW - Steroids--toxicity--angiosarcoma, hepatic, patients;
KW - Toxicity--steroids--angiosarcoma, hepatic, patients;
KW - Toxicity--testosterone enanthate--angiosarcoma, hepatic, patients;
KW - Toxicity--fluoxymesterone--angiosarcoma, hepatic, patients;
KW - Toxicity--methyltestosterone--angiosarcoma, hepatic, patients;
KW - Toxicity--methandrostenolone--angiosarcoma, hepatic, patients;
KW - Toxicity--stanozolol--angiosarcoma, hepatic, patients;
KW - Toxicity--methyltestosterone--alone and with ethinyl estradiol, angiosarcoma, hepatic, patients;
KW - Toxicity--ethinyl estradiol, combination, methyltestosterone--angiosarcoma, hepatic, patients;
KW - Statistics--steroids--toxicity, angiosarcoma, hepatic, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Halperin, William
AU - Weiss, William I.
AU - Altman, Ronald
AU - Diamond, Michael A.
AU - Black, Kenneth J.
AU - Laci, Alfred W.
AU - Black, Henry C.
AU - Goldfield, Martin
T1 - A Comparison of the Intradermal and Subcutaneous Routes of Influenza Vaccination with A/New Jersey/76 (Swine Flu) and A/Victoria/75: Report of a Study and Review of the Literature.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/12//
VL - 69
IS - 12
M3 - Article
SP - 1247
EP - 1251
PB - American Public Health Association
SN - 00900036
AB - Abstract: A trial of influenza vaccination, with use of bivalent split virus vaccine (A/New Jersey/76 and A/ Victoria/75), was conducted to compare the immunogenicity and reactions when vaccine was given by the subcutaneous and intradermal routes. Volunteers 18 to 24 years old were randomized into equal groups, one group receiving 0.1 ml of vaccine intradermally and the other receiving 0.5 ml subcutaneously. For the A/ Victoria vaccine, the immunogenicity of the intra dermal route seemed superior; for A/New Jersey vaccine, the routes were equivalent. Adverse reactions were minimal and equivalent for both groups. In times of vaccine shortage, the intradermal route is considered to stretch vaccine supplies. Field trials of new influenza vaccines should include evaluation of the immunogenicity of and adverse reactions caused by the same vaccine given by different routes in varied dosages. (Am J Public Health 69:1247-1250, 1979.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Public health
KW - VACCINATION
KW - Immunology
KW - Clinical trials
KW - Influenza
N1 - Accession Number: 5981594; Halperin, William 1; Weiss, William I. 2; Altman, Ronald 3; Diamond, Michael A. 4,5; Black, Kenneth J. 4,5; Laci, Alfred W. 4,5; Black, Henry C. 4,5; Goldfield, Martin 4,5; Affiliations: 1: Medical Officer, National Institute for Occupational Safety and Health, CDC, Cincinnati, OH.; 2: Chief, Allergy Section, Department of Medicine, St. Barnabas Medical Center.; 3: New Jersey State Department of Health, P.O. Box 1540, Trenton, NJ 08625.; 4: St. Barnabas Medical Center, Livington, NJ.; 5: Division of Laboratories and Epidemiology, New Jersey State Department of Health.; Issue Info: Dec1979, Vol. 69 Issue 12, p1247; Thesaurus Term: Communicable diseases; Thesaurus Term: Public health; Thesaurus Term: VACCINATION; Thesaurus Term: Immunology; Subject Term: Clinical trials; Subject Term: Influenza; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Thacker, S. B.;
AU - Simpson, S.;
AU - Gordon, T. J.;
AU - Wolfe, M.;
AU - Kimball, A. M.;
T1 - Parasitic disease control in a residential facility for the mentally retarded
CT - Parasitic disease control in a residential facility for the mentally retarded
JO - American Journal of Public Health (USA)
JF - American Journal of Public Health (USA)
Y1 - 1979/12/01/
VL - 69
IS - Dec
SP - 1279
EP - 1281
SN - 02714353
AD - Bureau of Epidemiology, Cent. for Disease Control, Public Health Service, Dept. of HEW, Atlanta, GA 30333
N1 - Accession Number: 17-01937; Language: English; Trade Name: Diiodohydroxyquin; Generic Name: Iodoquinol; Chemical Name: Iodoquinol--83-73-8 Quinacrine hydrochloride--6151-30-0 Metronidazole--443-48-1; Therapeutic Class: (8:04); AHFS Class: Amebicides iodoquinol (8:08); AHFS Class: Anthelmintics quinacrine hydrochloride (8:32); AHFS Class: Trichomonacides metronidazole; References: 15; Journal Coden: AJHEAA; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - Residents in an institution for the mentally retarded with asymptomatic infection with either Entamoeba histolytica or Giardia lamblia were treated with diiodohydroxyquin (iodoquinol; I) quinacrine hydrochloride (II) or metronidazole (III). I was used in doses of 650 mg 3 times/day for 20 days for patients with \IT/E. histolytica\OK/ infection. II was used in doses of 100 mg 3 times/day for 7 days for patients with \IT/G. lamblia\OK/ infection. III was used in doses of 35 to 50 mg/kg/day, in 3 divided doses, for 10 days in patients with mixed infections. Infection rates were found to be 61%, 20%, and 22% in 3 dormitories, drug therapy was successfully undertaken in all 3 domitories, and environmental improvements were introduced in the heavily infected dormitory. One yr follow-up showed a reduction in parasitic disease in 2 dormitories, but, in the most heavily infected dormitory, infection had returned to pretreatment levels. It was concluded that despite good case finding and therapy, intervention in this study was only partially successful.
KW - Iodoquinol--Entamoeba histolytica-;
KW - Quinacrine hydrochloride--Giardia lamblia-;
KW - Metronidazole--infections-;
KW - Entamoeba histolytica--iodoquinol--infections, therapy, institutionalized mentally retarded patients;
KW - Entamoeba histolytica--metronidazole--infections, therapy, institutionalized mentally retarded patients;
KW - Giardia lamblia--quinacrine hydrochloride--infections, therapy, institutionalized mentally retarded patients;
KW - Giardia lamblia--metronidazole--infections, therapy, institutionalized mentally retarded patients;
KW - Amebicides--iodoquinol--infections, E. histolytica, institutionalized mentally retarded patients;
KW - Anthelmintics--quinacrine hydrochloride--infections, G. lamblia, institutionalized mentally retarded patients;
KW - Trichomonacides--metronidazole--infections, E. histolytica, G. lamblia, institutionalized mentally retarded patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Holmes, K. K.;
T1 - Acute epididymitis
CT - Acute epididymitis
JO - Curr. Ther. Res. Clin. Exp.
JF - Curr. Ther. Res. Clin. Exp.
Y1 - 1979/12/01/
VL - 26
IS - Dec Suppl
SP - 738
EP - 744
AD - Univ. of Washington; and Div. of Infectious Disease, U.S. Public Health Service Hosp., Seattle, WA
N1 - Accession Number: 17-01675; Language: English; Chemical Name: Tetracycline hydrochloride--64-75-5 Doxycycline--17086-28-1; References: 3; Journal Coden: CTCEA9; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Nancy Lande
N2 - The etiology, clinical manifestations, and results of various treatments of acute epididymitis with tetracycline hydrochloride (I) or doxycycline (II) are discussed. Males over 35 yr of age were more likely to have infection with \IT/Escherichia coli, Klebsiella\OK/ species, or \IT/Pseudomonas aeruginosa.\OK/ Younger males were more likely to be infected with \IT/Neisseria gonorrhoeae\OK/ or \IT/Chlamydia trachomatis.\OK/ Treatment with I, 500 mg 4 times daily for 10 days, or with II, 100 mg twice daily for 10 days, was usually effective.
KW - Tetracycline hydrochloride--comparison, doxycycline-;
KW - Doxycycline--comparison, tetracycline hydrochloride-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1981-24221-001
AN - 1981-24221-001
AU - DiPaulo, Joe
T1 - Training of American Indian mental health professionals.
JF - White Cloud Journal of American Indian/Alaska Native Mental Health
JO - White Cloud Journal of American Indian/Alaska Native Mental Health
Y1 - 1980///
VL - 2
IS - 1
SP - 8
EP - 13
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0190-2482
N1 - Accession Number: 1981-24221-001. Other Journal Title: American Indian and Alaska Native Mental Health Research; White Cloud Journal of American Indian Mental Health. Partial author list: First Author & Affiliation: DiPaulo, Joe; Public Health Service Indian Health Ctr, Ft Totten, ND. Release Date: 19810801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Mental Health Inservice Training; Mental Health Personnel; Paraprofessional Education. Classification: Professional Education & Training (3410). Population: Human (10). Page Count: 6. Issue Publication Date: 1980.
AB - Responses from 43 of 71 American Indian mental health paraprofessionals asked to rate the adequacy of their training show that almost all of the Ss desired additional training, particularly education leading toward academic degrees. Inservice training was also valued. (12 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health paraprofessional training
KW - American Indians
KW - 1980
KW - American Indians
KW - Mental Health Inservice Training
KW - Mental Health Personnel
KW - Paraprofessional Education
KW - 1980
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Shellenberger, T. E.
T1 - Organophosphate pesticide inhibition of cholinesterase in laboratory animals and man and effects of oxine reactivators.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1980/01/06/
VL - 15
IS - 6
M3 - Article
SP - 795
EP - 822
SN - 03601234
AB - The responses of rabbit whole blood cholinesterase following intervaneous infusion or percutaneous application of dialkylphosphate inhibitors and injection of oxime enzyme reastivators. The experiments were conducted to determine the structure‐activity relationships of the inhibitors and the reactivators, establish the mechanisms of enzyme inhibition, and investigate other factors affecting the toxicity of organophosphate esters including percutaneous absorption and conversion of dithioates to the more reactive respective ozones. Intravenous infusion of dialkylphosphate esters produced dose and time dependent inhibition, followed by a spontaneous, but incomplete recovery . The lack of complete recovery was not totally due to the “aging”; phenomona as measurable enzyme reactivation could be induced subsequent to the spontaneous recovery. The need for revision of the enzyme inhibition model is discussed. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75452428; Shellenberger, T. E. 1; Affiliations: 1: Department of Health, Education and Welfare Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, 72079; Issue Info: Jan1980, Vol. 15 Issue 6, p795; Number of Pages: 28p; Document Type: Article
L3 - 10.1080/03601238009372218
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75452428&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kimbrough, Renate D.
T1 - Human health effects of selected pesticides, chloroaniline derivatives.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1980/01/06/
VL - 15
IS - 6
M3 - Article
SP - 977
EP - 992
SN - 03601234
AB - The health effects of two pesticides, chlordimeform and propanil, are discussed. Chlordimeform and 2‐methyl‐4‐chloroaniline, a major metabolite of chlordimeform, cause severe hemorrhagic cystitis in humans. In cats, however, only a mild effect on the bladder was noted. The herbicide propanil has produced chloracne in humans, and along with 3,4‐dichloroaniline, hyperkeratosis in rabbits. The contaminants 3,4,3’,4'‐tetrachloroazobenzene and 3,4,3’,4'‐tetrachloroazoxybenzene are responsible for the chloracnegenic characteristics of propanil, 3,4‐dichloroaniline, and methazole. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75452435; Kimbrough, Renate D. 1; Affiliations: 1: Toxicology Branch, Clinical Chemistry Division, Bureau of Laboratories, Center for Disease Control U.S. Public Health Service, Department of Health, Education, and Welfare, Atlanta, Georgia, 30333; Issue Info: Jan1980, Vol. 15 Issue 6, p977; Number of Pages: 16p; Document Type: Article
L3 - 10.1080/03601238009372225
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Philbrook, F. R.;
AU - Ingalls, T. H.;
T1 - Risk of contact infection after intranasal rubella vaccination
CT - Risk of contact infection after intranasal rubella vaccination
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1980/01/19/
VL - 1
IS - Jan 19
SP - 147
EP - 148
SN - 00237507
AD - Ambulatory Services Sect., U.S. Public Health Service Hosp., Brighton, MA
N1 - Accession Number: 17-01674; Language: English; Publication Type: Letters; Journal Coden: LANCAO; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Nancy Lande
N2 - Of 70 seronegative students, 26 were vaccinated with RA27/3 virus, 12 SC and 14 intranasally, and the others were observed for seroconversion. Pharyngeal swabs taken from the vaccinees 11 days after vaccination yielded virus isolation from 2 of the children given vaccine SC and 3 given the vaccine intranasally. Six weeks later, none of the nonvaccinated students had seroconverted. It was concluded that this evidence argues against spread by contact after intranasal immunization.
KW - Rubella vaccines--RA27/3-;
KW - Immunization--rubella--vaccines, RA27/3, intranasal, lack, contact infection, students;
KW - Drug administration routes--rubella vaccines--RA27/3, immunization, lack, contact infection, students;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Meisel, S.;
AU - Brower, R.;
T1 - Rifampin: suicidal dose
CT - Rifampin: suicidal dose
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1980/02/01/
VL - 92
IS - Feb (Part 1)
SP - 262
EP - 263
SN - 00034819
AD - U.S. Public Health Service Indian Hosp., Keams Canyon, AZ 86034
N1 - Accession Number: 17-02994; Language: English; Chemical Name: Rifampin--13292-46-1; References: 4; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Abstract Author: Nancy Lande
N2 - Marked facial and mucous membrane edema along with lethargy, obtundation, generalized pruritis, abnormal liver function tests, and orange discoloration of the skin occurred in a 15-yr-old girl after an overdosage of rifampin. Supportive therapy resulted in the resolution of the symptoms.
KW - Rifampin--poisoning-;
KW - Poisoning--rifampin--therapy, overdose patient;
KW - Toxicity--rifampin--poisoning, therapy, overdose patient;
KW - Dosage--rifampin--overdose, patient;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Copeland, G. P.;
AU - Apgar, D. A.;
T1 - Pharmacist practitioner training program
CT - Pharmacist practitioner training program
JO - Drug Intell. Clin. Pharm.
JF - Drug Intell. Clin. Pharm.
Y1 - 1980/02/01/
VL - 14
IS - Feb
SP - 114
EP - 119
AD - Indian Health Service, Clin. Continuing Education Cent., 4212 N. 16th St., Phoenix, AZ 85016
N1 - Accession Number: 17-06147; Language: English; Language of Summary: fr; References: 4; Journal Coden: DICPBB; Section Heading: Pharmaceutical Education
N2 - The evolution of the Indian Health Service Pharmacist Practitioner Training Program, the training and experience received through the program and the utilzation of graduates in the clinical setting are discussed. The expanded role for the pharmacist completing this program includes compilation of complete medical histories, physical examination, diagnosis, and treatment of outpatients with selected acute and chronic illnesses.
KW - Pharmacists--health care--role, expansion, Pharmacist Practitioner Training Program;
KW - Health care--pharmacists--role, expansion, Pharmacist Practitioner Training Program;
KW - Education, pharmaceutical--health care--Pharmacist Practitioner Training Program, role expansion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - PRIVAL, MICHAEL J.
AU - MITCHELL, VALERIE D.
AU - GOMEZ, YOLANDA P.
T1 - Mutagenicity of a New Hair Dye Ingredient: 4-Ethoxy-m-phenylenediamine.
JO - Science
JF - Science
Y1 - 1980/02/22/
VL - 207
IS - 4433
M3 - Article
SP - 907
EP - 908
SN - 00368075
AB - An ingredient recently introduced in hair dyes, 4-ethoxy-m-phenylenediamine, is mutagenic in histidine-requiring strains of Salmonella typhimurium. Its mutagenic activity is similar to that of the hair dye ingredient it apparently replaced, 4-methoxy-m-phenylenediamine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85361651; PRIVAL, MICHAEL J. 1; MITCHELL, VALERIE D. 1; GOMEZ, YOLANDA P. 1; Affiliations: 1: Genetic Toxicology Branch, Food and Drug Administration, Washington, D.C. 20204; Issue Info: 2/22/1980, Vol. 207 Issue 4433, p907; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Snippe, H.
AU - Willers, J. M. N.
AU - Inman, J. K.
AU - Merchant, B.
T1 - The specificity of antibody formation in mice following immunization with hapten-carrier complexes mixed with the surfactant, dimethyl dioctadecyl ammonium bromide.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 361
EP - 366
SN - 00192805
AB - Mice were immunized i.e. with various enlarged haptens conjugated to bovine serum albumin and mixed with the cationic, surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA). This immunization generated delayed-type hypersensitivity (DH) in these mice without detectable concomitant antibody formation. The DH was measured as footpad swelling. However, both direct and indirect hapten-specific PFC could be detected in peripheral lymph nodes and in spleens 4 days after a challenge injection. Although the adjuvant, DDA, promotes a strong cross-reactivity in DH between heterologous hapten--carrier complexes, the antibody-forming cells produced 4 days after challenge showed relatively high specificity for the immunizing hapten. This indicates only weak cross-reactivity at the anti-body-forming cell level co-existent with high cross-reactivity in DH expression to the same hapten-carrier complexes. These results are consistent with the possibility that B-cell receptors may be capable of expressing a greater degree of hapten specificity than T-cell receptors. It is tentatively concluded that Thelper cells participating in antibody formation may represent a subset of the T cells involved in DH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOGLOBULINS
KW - HAPTENS
KW - SURFACE active agents
KW - SERUM albumin
KW - MICE as laboratory animals
N1 - Accession Number: 13520411; Snippe, H. 1; Willers, J. M. N. 1; Inman, J. K. 2; Merchant, B. 3; Source Information: Mar1980, Vol. 39 Issue 3, p361; Subject: IMMUNIZATION; Subject: IMMUNOGLOBULINS; Subject: HAPTENS; Subject: SURFACE active agents; Subject: SERUM albumin; Subject: MICE as laboratory animals; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Snippe, H.
AU - Johannesen, L.
AU - Lizzio, Elaine
AU - Merchant, B.
T1 - Variable expression of delayed hypersensitivity in different mouse strains using dimethyl dioctadecyl ammonium bromide as an adjuvant.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 399
EP - 405
SN - 00192805
AB - Delayed-type hypersensitivity measured as footpad swelling was studied in a large number of inbred mouse strains. A conjugate of bovine serum albumin (BSA) with the small 2.4-dinitrophenyl (DNP) hapten served to generate strong reactions, specific for the DNP group. Delayed hypersensitivity was produced with the DNP-BSA complex mixed with the cationic, surface active lipid. dimethyl dioctadecyl ammonium bromide (DDA). Great variation was observed in delayed hypersensitivity among different mouse strains. For convenience, the mice were classified into five groups, notably: non-, low, moderate, good and high responders. The highest responding animals were HALB/cJ mice, the lowest were PJJN and outbred nu/nu mice. No correlation was observed between 1-1-2 type and the intensity of the elicited reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - SERUM albumin
KW - DINITROBENZENES
KW - HAPTENS
KW - IMMUNOLOGY
KW - MICE as laboratory animals
N1 - Accession Number: 13520532; Snippe, H. 1; Johannesen, L. 1; Lizzio, Elaine 1; Merchant, B. 1; Source Information: Mar1980, Vol. 39 Issue 3, p399; Subject: ALLERGY; Subject: SERUM albumin; Subject: DINITROBENZENES; Subject: HAPTENS; Subject: IMMUNOLOGY; Subject: MICE as laboratory animals; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Barkdoll, Gerald L.
AU - Stenberg, Carl W.
T1 - Type III Evaluations: Consultation and Consensus.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1980/03//Mar/Apr80
VL - 40
IS - 2
M3 - Article
SP - 174
EP - 179
PB - Wiley-Blackwell
SN - 00333352
AB - This article explores the evaluation program of the U.S. Food and Drug Administration (FDA) to improve the quality, acceptance and use of evaluation. The evolution of evaluation at FDA has proceeded through three distinct phases, each distinguished by a different type of evaluation activity. The agency has adopted Type II evaluation since it focused on the collection and manipulation of analytical data. Type II evaluations were designed to withstand aggressive peer review. A number of achievements and advantages of the Type II evaluations are also presented in this article.
KW - GOVERNMENT productivity
KW - PUBLIC administration
KW - GOVERNMENT agencies
KW - EVALUATION
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 4601760; Barkdoll, Gerald L. 1; Stenberg, Carl W. 1; Affiliations: 1: U.S. Food and Drug Administration; Issue Info: Mar/Apr80, Vol. 40 Issue 2, p174; Thesaurus Term: GOVERNMENT productivity; Thesaurus Term: PUBLIC administration; Thesaurus Term: GOVERNMENT agencies; Subject Term: EVALUATION; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1981-08526-001
AN - 1981-08526-001
AU - Beasley, B. L.
AU - Nutt, J. G.
AU - Davenport, R. W.
AU - Chase, T. N.
T1 - Treatment with tryptophan of levodopa-associated psychiatric disturbances.
JF - Archives of Neurology
JO - Archives of Neurology
JA - Arch Neurol
Y1 - 1980/03//
VL - 37
IS - 3
SP - 155
EP - 156
CY - US
PB - American Medical Association
SN - 0003-9942
SN - 1538-3687
N1 - Accession Number: 1981-08526-001. PMID: 7356421 Other Journal Title: A.M.A. Archives of Neurology; JAMA Neurology. Partial author list: First Author & Affiliation: Beasley, B. L.; US Public Health Service Hosp, Dept of Neurology, Staten Island, NY. Release Date: 19810401. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Levodopa; Parkinson's Disease; Side Effects (Drug); Tryptophan. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 2. Issue Publication Date: Mar, 1980.
AB - The effect of 2–6 g/day of tryptophan on levodopa-induced psychiatric symptoms was tested in 9 patients with Parkinson's disease in a double-blind, placebo-controlled trial. The psychiatric disturbances were not greatly altered by administration of tryptophan. (12 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tryptophan
KW - levodopa induced psychiatric symptoms
KW - Parkinson's disease patients
KW - 1980
KW - Drug Therapy
KW - Levodopa
KW - Parkinson's Disease
KW - Side Effects (Drug)
KW - Tryptophan
KW - 1980
DO - 10.1001/archneur.1980.00500520053008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1981-08526-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42212-001
AN - 2013-42212-001
AU - Brown, Bertram S.
T1 - Milton F. Shore, Ph.D. President, American Orthopsychiatric Association.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1980/04//
VL - 50
IS - 2
SP - 196
EP - 197
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2013-42212-001. PMID: 6987892 Partial author list: First Author & Affiliation: Brown, Bertram S.; United States Public Health Service, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Collaboration; Human Development; Humanism; Mental Health; Social Workers. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 1980.
AB - This article focuses on the contribution of the Milton F. Shore, President of American Orthopsychiatric Association from 1980-1981. Throughout his career lie has promoted the essential presence of mental health considerations in the broad context of human development. His credentials for doing so are impeccable. Milt Shore, the gentle advocate, brings that strength to the presidency of the American Orthopsychiatric Association. In that dimension which distinguishes orthopsychiatry- the collaborative efforts of judges, educators, psychiatrists, psychologists, social workers, nurses, and others rotating the presidency and working toward the ultimate goals of mental health. In the face of demands by some that mental health adhere ever more closely to ;I medical model, tlie gentle advocate responds without rhetoric or vitriol but with a persistent and convincing enunciation of the merits of a broad, humanistic approach to the resolution of developmental issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - collaborative efforts
KW - human development
KW - humanistic approach
KW - mental health considerations
KW - social workers
KW - 1980
KW - Collaboration
KW - Human Development
KW - Humanism
KW - Mental Health
KW - Social Workers
KW - 1980
DO - 10.1111/j.1939-0025.1980.tb03279.x
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Meecham, William C.
AU - Shaw, Neil
AU - Frerichs, Ralph R.
AU - Coulson, Anne Hersey
AU - Stenvig, Thomas E.
AU - Brosseau, James D.
AU - Bader, Max
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/05//
VL - 70
IS - 5
M3 - Letter
SP - 543
PB - American Public Health Association
SN - 00900036
AB - Several letters to the editor are presented in response to articles in previous issues including one on "Los Angeles Airport Noise and Mortality: Faulty Analysis and Public Policy," "Diabetes Among the Three Affiliated Tribes: Correlation with Degree of Indian Inheritance," in the December 1979 issue, and another one on the intradermal and subcutaneous routes of influenza vaccination.
KW - Airport noise
KW - Influenza
KW - Vaccination
KW - Letters to the editor
KW - Diabetes
N1 - Accession Number: 4954578; Meecham, William C. 1; Shaw, Neil; Frerichs, Ralph R. 2; Coulson, Anne Hersey 3; Stenvig, Thomas E. 4; Brosseau, James D. 5; Bader, Max; Affiliations: 1: Professor, Mechanics and Structures Department, University of California, Los Angeles School of Engineering & Applied Science Los Angeles, CA 90024; 2: Assistant Professor, Division of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90024; 3: Research Epidemiologist, Division of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90024; 4: Deputy Chief, Area Nursing Branch, Aberdeen Area Indian Health Service, Federal Building, Aberdeen, SD S7401; 5: Associate Professor, Dept. of Community Medicine, University of North Dakota, Grand Forks, ND 58201; Issue Info: May80, Vol. 70 Issue 5, p543; Thesaurus Term: Airport noise; Thesaurus Term: Influenza; Thesaurus Term: Vaccination; Subject Term: Letters to the editor; Subject Term: Diabetes; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1981-11948-001
AN - 1981-11948-001
AU - Christensen-Szalanski, Jay J.
AU - Goldberg, Alice D.
AU - Anderson, Mark E.
AU - Mitchell, Terence R.
T1 - Deprivation, delay of reinforcement, and the selection of behavioural strategies.
JF - Animal Behaviour
JO - Animal Behaviour
JA - Anim Behav
Y1 - 1980/05//
VL - 28
IS - 2
SP - 341
EP - 346
CY - Netherlands
PB - Elsevier Science
SN - 0003-3472
SN - 1095-8282
N1 - Accession Number: 1981-11948-001. Other Journal Title: British Journal of Animal Behaviour. Partial author list: First Author & Affiliation: Christensen-Szalanski, Jay J.; US Public Health Service Hosp, Dept of Health Services Research, Seattle, WA. Release Date: 19810601. Correction Date: 20170123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Operant Conditioning; Preferences; Reinforcement Amounts; Reinforcement Schedules; Water Deprivation. Minor Descriptor: Rats. Classification: Learning & Motivation (2420). Population: Animal (20). Page Count: 6. Issue Publication Date: May, 1980.
AB - Tested 34 Long-Evans rats with different histories of water deprivation at different levels of present water deprivation in a choice condition. Ss had to choose between a small water reinforcement delayed a short period of time and a large water reinforcement delayed a longer period of time. Ss expressed a greater preference for the larger, more delayed reinforcement when they were either presently deprived of water or had a past history of water deprivation. Results are discussed in the context of present ecological models and the conditions during which Ss would be expected to behave according to those models. (25 ref) (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - present & past water deprivation level
KW - choice of long delay/large water reinforcement vs short delay/small reinforcement
KW - rats
KW - 1980
KW - Operant Conditioning
KW - Preferences
KW - Reinforcement Amounts
KW - Reinforcement Schedules
KW - Water Deprivation
KW - Rats
KW - 1980
DO - 10.1016/S0003-3472(80)80042-X
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Byer, B
AU - Goetze, F
T1 - National drug code directory data file
JO - National drug code directory data file
JF - National drug code directory data file
Y1 - 1980/05/02/
M3 - Book
AB - Reel 009571 is standard 6250 bpi tape which contains 248,317 variable length records. There are 4 record types: (1) type 1 records contain basic information including the ndc, trade name, labeler, route of administration, dose form, etc; (2) type 2 records contain information about packaging such as package code, type and size; (3) type 3 records contain information about ingredient. The printed directory includes a maximum of 3 ingredients. The data tape includes all active ingredients; (4) type 4 records contain information about the drug class
N1 - Accession Number: ISTA1703832; Byer, B; Goetze, F 2; Affiliations: 2 : Food and Drug Administration, Rockville, MD. Drug Listing Branch; Source Info: May 2, 1980; Note: Update Code: 1700; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Rosenstein, David I.
AU - Joseph, Lireka P.
AU - MacKenzie, Leslie J.
AU - Wyden, Ron
T1 - Professional Encroachment: A Comparison of the Emergence of Denturists in Canada and Oregon.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/06//
VL - 70
IS - 6
M3 - Article
SP - 614
PB - American Public Health Association
SN - 00900036
AB - In 1978, supporters of denturism in Oregon succeeded in passing an initiative which allows denturists to provide dentures directly to the public. The steps which led to the referendum included three unsuccessful attempts to have the state legislature enact a law legalizing denturism, After capturing broad-based consumer support, the issue was placed on the ballot and passed by an overwhelming margin. Both the denturists and the dentists in Oregon adopted strategies similar to those used in Canada over 20 years ago when the issue was raised in a number of provinces. As was the case in Canada, the denturists prevailed. Denturists stressed the price differential and the issue of freedom of choice. Dentists stressed health and safety issues. The public perceived the dentists' campaign as negative and self-serving. This perception may have contributed to the election results. In order to avoid this tarnished image, dentists must anticipate the public's needs, and formulate strategies to meet such needs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dentures
KW - Dental care
KW - Dentists
KW - Canadian provinces
KW - Legislative bodies
KW - Legislation
KW - Oregon
KW - Canada
KW - United States
N1 - Accession Number: 4954760; Rosenstein, David I. 1; Joseph, Lireka P. 2; MacKenzie, Leslie J. 3; Wyden, Ron 4; Affiliations: 1: Associate Professor and Chairman, Department of Public Health Dentistry, School of Dentistry, University of Oregon, Health Sciences Center, 611 S.W. Campus Drive, Portland, OR 97201; 2: Medical Radiation Specialist, Food and Drug Administration, DHEW; 3: Assistant Professor, Department of Public Health Dentistry; 4: Co-Director, Oregon Gray Panthers; Issue Info: Jun80, Vol. 70 Issue 6, p614; Subject Term: Dentures; Subject Term: Dental care; Subject Term: Dentists; Subject Term: Canadian provinces; Subject Term: Legislative bodies; Subject Term: Legislation; Subject: Oregon; Subject: Canada; Subject: United States; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 921120 Legislative Bodies; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Stamm, W. E.;
AU - Counts, G. W.;
AU - Wagner, K. F.;
AU - Martin, D.;
AU - Gregory, D.;
AU - \ET/;
T1 - Antimicrobial prophylaxis of recurrent urinary tract infections
CT - Antimicrobial prophylaxis of recurrent urinary tract infections
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1980/06/01/
VL - 92
IS - Jun
SP - 770
EP - 775
SN - 00034819
AD - Div. of Infectious Diseases, Dept. of Med., Univ. of Washington School of Med., Harborview Med. Cent., and U.S. Public Health Service Hosp., Seattle, WA
N1 - Accession Number: 17-05318; Language: English; Trade Name: Septra; Generic Name: Sulfamethoxazole; Chemical Name: Trimethoprim--738-70-5 Sulfamethoxazole--723-46-6 Nitrofurantoin--67-20-9; References: 18; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - The antimicrobial prophylaxis of urinary tract infections was studied in 45 women given 40 mg trimethoprim and 200 mg sulfamethoxazole (Septra; I) or 100 mg nitrofurantoin macrocrystals (II); 15 additional women with allergy to sulfonamide or II received 100 mg trimethoprim (III) alone. All drugs were given orally daily for 6 months. During prophylaxis, infections/patients yr were comparable in the groups receiving III (0.0), II (0.14), or I (0.15) and occurred less frequently than in patients receiving placebo (2.8). The effectiveness of prophylaxis was limited to the 6 months that antimicrobials were given, and infections were more likely to develop after prophylaxis in women who had 3 or more infections in a yr before prophylaxis. It was concluded that prophylaxis with these drugs is effective, well tolerated, and did not produce emergence of resistant \IT/E. coli\OK/ but may predispose to non-\IT/E. coli\OK/ urinary tract infections after its discontinuation.
KW - Trimethoprim--alone and with sulfamethoxazole-;
KW - Sulfamethoxazole--combination, trimethoprim-;
KW - Nitrofurantoin--dosage schedules-;
KW - Dosage schedules--trimethoprim--alone and with sulfamethoxazole, prophylaxis, recurrent urinary tract infections, female patients;
KW - Dosage schedules--sulfamethoxazole, combination, trimethoprim--prophylaxis, recurrent urinary tract infections, female patients;
KW - Dosage schedules--nitrofurantoin--prophylaxis, recurrent urinary tract infections, female patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - HOGABOOM, G. KURT
AU - O'DONNELL, JOHN P.
AU - FEDAN, JEFFREY S.
T1 - Purinergic Receptors: Photoaffinity Analog of Adenosine Triphosphate Is a Specific Adenosine Triphosphate Antagonist.
JO - Science
JF - Science
Y1 - 1980/06/13/
VL - 208
IS - 4449
M3 - Article
SP - 1273
EP - 1276
SN - 00368075
AB - Arvlazido aminopropionyl adenosine triphosphate (ANAPP3), a photoaffinity label, antagonized specifically adenine nucleotide-induced contractions of the guinea pig vas deferens. Irradiation of tissues with visible light in the presence of ANAPP3 resuilted in an irreversible antagonism, which was prevented when adenosine triphosphate was present. In the absence of light, the antagonism was reversible and may have resiulted from an aiutoinhibition phenomenon. Responses to acetylcholine, histamine, norepinephrine, and potassium chloride wtere not affected by ANAPP3. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85437678; HOGABOOM, G. KURT 1,2; O'DONNELL, JOHN P. 3,4; FEDAN, JEFFREY S. 1,2,4; Affiliations: 1: Department of Pharmacology, West Virginia University Medical Center, Morgantown 26506; 2: Department of Toxicology, West Virginia University Medical Center, Morgantown 26506; 3: School of Pharmacy, West Virginia University Medical Center; 4: Physiology Section, Appalachian Laboratory, Occupational Safety and Health, National Institute of Occupational Safety and Health, Morgantown 26505; Issue Info: 6/13/1980, Vol. 208 Issue 4449, p1273; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sacks, Jeffrey J.
AU - Krushat, Mark
AU - Newman, Jeffrey
T1 - Reliability of the Health Hazard Appraisal.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/07//
VL - 70
IS - 7
M3 - Article
SP - 730
PB - American Public Health Association
SN - 00900036
AB - Abstract: As part of a controlled clinical trial of Health Hazard Appraisal's (HHA) efficacy in stimulating risk reduction, the reliability of the HHA questionnaire was evaluated. Of 203 subjects, only 30 (15 per ¢) had no contradictions when comparing the responses of the follow-up with baseline questionnaire. Overall, there was an average of 1.6 contradictions per subject. Failure to control for reliability may account for apparent reduction of risk reported in previous studies of HHA. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Public health
KW - RESEARCH
KW - Reliability (Personality trait)
KW - Preventive medicine
KW - Clinical medicine
KW - Statistical reliability
KW - Medical research
KW - Clinical trials
KW - Medical care
N1 - Accession Number: 4954406; Sacks, Jeffrey J. 1; Krushat, Mark 2; Newman, Jeffrey 3; Affiliations: 1: Public Health Service Hospital, San Francisco.; 2: Biostatistician, Research Coordination Branch.; 3: Chairman, Department of Preventive Medicine.; Issue Info: Jul1980, Vol. 70 Issue 7, p730; Thesaurus Term: Health risk assessment; Thesaurus Term: Public health; Thesaurus Term: RESEARCH; Subject Term: Reliability (Personality trait); Subject Term: Preventive medicine; Subject Term: Clinical medicine; Subject Term: Statistical reliability; Subject Term: Medical research; Subject Term: Clinical trials; Subject Term: Medical care; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Olenchock, S. A.
AU - Mull, J. C.
AU - Major, P. C.
T1 - Complement activation by commercial allergen extracts of cereal grains.
JO - Clinical Allergy: Journal of the British Allergy Society
JF - Clinical Allergy: Journal of the British Allergy Society
Y1 - 1980/07//
VL - 10
IS - 4
M3 - Article
SP - 395
EP - 404
SN - 00099090
AB - Commercial allergen extract preparations of whole cereal grains were examined in vitro for their reactivity with the human haemolytic complement cascade. Total haemolytic complement was consumed in a dose-dependent manner which did not correlate with the protein nitrogen content or bacterial endotoxin contamination of the extracts. Alternative pathway activation was shown by C3 conversion in the presence of EGTA while classical complement components C1, C4 and C2 were also much decreased in serum which was free of detectable specific antibody. Very small amounts of allergen extract initiated the formation of complement-dependent factors which were chemotactic for human polymorphonuclear leucocytes. These data suggest a potential for complement activation in vivo by ingestion, inhalation, or injection of cereal grain products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Allergy: Journal of the British Allergy Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - GRAIN
KW - CEREAL grasses
KW - PROTEIN nitrogen
KW - ENDOTOXINS
KW - NEUTROPHILS
N1 - Accession Number: 16471629; Olenchock, S. A. 1,2; Mull, J. C. 1,2; Major, P. C. 1,2; Source Information: Jul1980, Vol. 10 Issue 4, p395; Subject: ALLERGENS; Subject: GRAIN; Subject: CEREAL grasses; Subject: PROTEIN nitrogen; Subject: ENDOTOXINS; Subject: NEUTROPHILS; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
TY - GEN
AU - Carlson, M.;
AU - Habeger, L. E.;
T1 - Polarographic determination of edetate disodium in eyewash and ophthalmic decongestant solutions
CT - Polarographic determination of edetate disodium in eyewash and ophthalmic decongestant solutions
JO - Journal of Pharmaceutical Sciences (USA)
JF - Journal of Pharmaceutical Sciences (USA)
Y1 - 1980/07/01/
VL - 69
IS - Jul
SP - 826
EP - 828
SN - 00223549
AD - Minneapolis District, FDA, Public Health Service, Dept. of HEW, Minneapolis, MN 55401
N1 - Accession Number: 19-02621; Language: English; Chemical Name: Edetate disodium--139-33-3; Therapeutic Class: (64:00); AHFS Class: Chelating agents edetate disodium; References: 9; Journal Coden: JPMSAE; Section Heading: Drug Analysis; Abstract Author: Lilia M. Sancho
N2 - A differential pulse polarographic method using a dropping mercury electrode employed in the quantitative analysis of edetate disodium in simulated nonprescription eyewash and ophthalmic solutions is described. The method is sensitive and rapid, and the assay results demonstrate the validity of the analysis.
KW - Edetate disodium--polarography-;
KW - Polarography--edetate disodium--solutions, ophthalmic, differential pulse;
KW - Chelating agents--edetate disodium--solutions, ophthalmic, differential pulse polarography;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Richmond, J. B.;
T1 - Alcohol-drug interactions
CT - Alcohol-drug interactions
JO - Pharmacy Times (USA)
JF - Pharmacy Times (USA)
Y1 - 1980/08/01/
VL - 46
IS - Aug
SP - 74
EP - 82
SN - 00030627
AD - U.S. Public Health Service, Dept. of Health and Human Services, Washington, DC
N1 - Accession Number: 18-03644; Language: English; Trade Name: Antabuse; Generic Name: Disulfiram; Chemical Name: Alcohols, ethyl--64-17-5 Disulfiram--97-77-8; Journal Coden: PYTMAO; Section Heading: Drug Interactions; Pharmacology; Abstract Author: Walter F. Stanaszek
N2 - The physical and behavioral effects of some prevalent alcohol and drug interactions in occasional or moderate drinkers and chronic alcoholics are discussed. The side effects resulting from the interactions between alcohol and examples from each of the following classes of drugs: analgesics; anticoagulants; anticonvulsants; antidepressants; antidiabetic agents; anti-alcohol drugs like disulfiram (Antabuse); antihistamines; antibiotics; fungicides; central nervous system stimulants; diuretics; hypotensive agents; sedatives and hypnotics; tranquilizers are given. The mechanisms of the interactions are also given. The community pharmacist's role in informing both physicians and patients of the problems that may be encountered with the interactions of alcohol and drugs is suggested.
KW - Alcohols, ethyl--interactions-;
KW - Disulfiram--interactions-;
KW - Drug interactions--alcohols, ethyl--side effects, control, community pharmacists, role;
KW - Toxicity--alcohols, ethyl--interactions, drugs, side effects, control, community pharmacists, role;
KW - Mechanism of action--alcohols, ethyl--interactions, drugs, side effects, discussion;
KW - Drug interactions--analgesics and alcohols, ethyl--side effects, discussion;
KW - Antihistamines--interactions--alcohols, ethyl, side effects, discussion;
KW - Analgesics and antipyretics--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--antihistamines and alcohols, ethyl--side effects, discussion;
KW - Anticoagulants--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--anticoagulants and alcohols, ethyl--side effects, discussion;
KW - Antidepressants--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--antidepressants and alcohols, ethyl--side effects, discussion;
KW - Antidiabetic agents--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--antidiabetic agents and alcohols, ethyl--side effects, discussion;
KW - Alcoholism--disulfiram--toxicity, interactions, side effects, discussion;
KW - Antibiotics--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--antibiotics and alcohols, ethyl--side effects, discussion;
KW - Fungicides--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--fungicides and alcohols, ethyl--side effects, discussion;
KW - Central nervous system stimulants--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--central nervous system stimulants and alcohols, ethyl--side effects, discussion;
KW - Diuretics--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--diuretics and alcohols, ethyl--side effects, discussion;
KW - Hypotensive agents--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--hypotensive agents and alcohols, ethyl--side effects, discussion;
KW - Sedatives and hypnotics--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--sedatives and hypnotics and alcohols, ethyl--side effects, discussion;
KW - Tranquilizers--interactions--alcohols, ethyl, side effects discussion;
KW - Drug interactions--tranquilizers and alcohols, ethyl--side effects, discussion;
KW - Anticonvulsants--interactions--alcohols, ethyl, side effects, discussion;
KW - Drug interactions--anticonvulsants and alcohols, ethyl--side effects, discussion;
KW - Patient information--consultation--alcohols, ethyl, drug interactions, community pharmacists, role;
KW - Physicians--consultation--alcohols, ethyl, drug interactions, community pharmacists, role;
KW - Pharmacists, community--consultation--alcohols, ethyl, drug interactions, patients and physicians;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Brown, M. J.;
AU - Salmon, D.;
AU - Rendell, M.;
T1 - Clonidine hallucinations
CT - Clonidine hallucinations
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1980/09/01/
VL - 93
IS - Sep
SP - 456
EP - 457
SN - 00034819
AD - Johns Hopkins Hosp.; and the U.S. Public Health Service Hosp., Baltimore, MD
N1 - Accession Number: 17-05634; Language: English; Chemical Name: Clonidine hydrochloride--4205-91-8; Therapeutic Class: (24:08); AHFS Class: Hypotensive agents clonidine hydrochloride; References: 6; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Drug Evaluations; Abstract Author: Elvira deC. Weiss
N2 - Reported are 3 cases of hallucinations in hypertensive patients given oral clonidine hydrochloride (I), 100-200 \mu/g daily. In the first 2 cases I was stopped; in the third treatment was continued and the hallucinations eventually vanished.
KW - Clonidine hydrochloride--toxicity-;
KW - Toxicity--clonidine hydrochloride--hallucinations, hypertensive patients;
KW - Hypotensive agents--clonidine hydrochloride--hallucinations, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Blanchard, Evelyn Lance
AU - Barsh, Russel Lawrence
T1 - What is best for tribal children? a response to Fischler.
JO - Social Work
JF - Social Work
Y1 - 1980/09//
VL - 25
IS - 5
M3 - Article
SP - 350
EP - 357
PB - Oxford University Press / USA
SN - 00378046
AB - The passage of the Indian Child Welfare Act has caused great concern and misunderstanding among social workers. The authors discuss American Indian child-rearing practices and their implications for social work and clarify some of the most frequently misunderstood provision of the act. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE American children -- Legal status, laws, etc.
KW - SOCIAL workers
KW - CHILD rearing
KW - SOCIAL work with children
KW - CHILD welfare
KW - UNITED States
N1 - Accession Number: 5268881; Blanchard, Evelyn Lance 1,2; Barsh, Russel Lawrence 3; Source Information: Sep80, Vol. 25 Issue 5, p350; Subject: NATIVE American children -- Legal status, laws, etc.; Subject: SOCIAL workers; Subject: CHILD rearing; Subject: SOCIAL work with children; Subject: CHILD welfare; Geographic Terms: UNITED States; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1980-32775-001
AN - 1980-32775-001
AU - DeHart, Rufus M.
T1 - Coronary heart disease: An expensive Air Force problem.
JF - Aviation, Space, and Environmental Medicine
JO - Aviation, Space, and Environmental Medicine
JA - Aviat Space Environ Med
Y1 - 1980/09//
VL - 51
IS - 9, Section 2
SP - 1057
EP - 1063
CY - US
PB - Aerospace Medical Assn
SN - 0095-6562
N1 - Accession Number: 1980-32775-001. Other Journal Title: Aerospace Medicine; Aerospace Medicine and Human Performance. Partial author list: First Author & Affiliation: DeHart, Rufus M.; US Air Force Medical Service Ctr, Office of the Surgeon General, Brooks Air Force Base, TX. Release Date: 19801201. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Air Force Personnel; Cardiovascular Disorders; Etiology; Personality Traits; Predisposition. Minor Descriptor: Costs and Cost Analysis; Epidemiology. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Military Psychology (3800). Population: Human (10). Page Count: 7. Issue Publication Date: Sep, 1980.
AB - Death or disability from coronary heart disease (CHD) is a major problem that costs the US Air Force $50 million annually. The significance of various risk factors associated with increased incidence of CHD is discussed, including the psychological factors accompanying the Type A personality: excessive drive, impatience, overcommitment to job, intense competitiveness, achievement orientation, strong sense of duty, time urgency, and abruptness of speech and gestures. (26 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological risk factors related to increased coronary heart disease incidence & associated manpower cost
KW - US Air Force personnel
KW - 1980
KW - Air Force Personnel
KW - Cardiovascular Disorders
KW - Etiology
KW - Personality Traits
KW - Predisposition
KW - Costs and Cost Analysis
KW - Epidemiology
KW - 1980
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - NGUYEN-DINH, PHUC
AU - CAMPBELL, CARLOS C.
AU - COLLINS, WILLIAM E.
T1 - Cultivation in vitro of the Quartan Malaria Parasite Plasmodium inui.
JO - Science
JF - Science
Y1 - 1980/09/12/
VL - 209
IS - 4462
M3 - Article
SP - 1249
EP - 1251
SN - 00368075
AB - The simian quartan malaria parasite Plasmodium inui (OS strain) was cultured in a continuous flow system with rhesus monkey erythrocytes and RPMi 1640 medium supplemented with Hepes buffer and rhesus serum. Over a 10-week period, the growth of the parasite permitted a 61,000-fold cumulative dilution of the original inoculum. After S weeks in culture, the parasites were still infective to the monkey Saimiri sciureus and to Anopheles freeborni mosquitoes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 85266557; NGUYEN-DINH, PHUC 1; CAMPBELL, CARLOS C. 1; COLLINS, WILLIAM E. 1; Affiliations: 1: Vector Biology and Control Division, Bureau of Tropical Diseases, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333; Issue Info: 9/12/1980, Vol. 209 Issue 4462, p1249; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Methadone for treating narcotic addicts: joint revision of conditions for use
CT - Methadone for treating narcotic addicts: joint revision of conditions for use
JO - Federal Register (USA)
JF - Federal Register (USA)
Y1 - 1980/09/19/
VL - 45
IS - Sep 19
SP - 62693
EP - 62718
SN - 00976326
AD - Bureau of Drugs, (HFD-30), Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857
N1 - Accession Number: 17-05800; Language: English; Chemical Name: Methadone--76-99-3; Journal Coden: FEREAC; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and Ethics; Abstract Author: Joseph A. Cornell
N2 - Finalized revisions, effective Nov. 18, 1980, to the conditions for use of methadone in the treatment of narcotic addicts are published jointly by the National Institute on Drug Abuse and the Food and Drug Administration. Eighty-seven comments from interested parties on the proposed regulations published on Oct. 28, 1977 are summarized and the modifications of regulations pertinent to each comment are presented.
KW - Methadone--maintenance-;
KW - Regulations--methadone--dependence, FDA;
KW - Laws--methadone--dependence, FDA;
KW - Food and Drug Administration (U.S.)--methadone--regulations, revised;
KW - National Institute on Drug Abuse--Food and Drug Administration (U.S.)--methadone, maintenance, regulations, revision;
KW - Dependence--narcotics--therapy, methadone maintenance, regulations, revision, FDA;
KW - Narcotics--dependence--therapy, methadone maintenance, regulations, revision, FDA;
KW - Drug abuse--narcotics--therapy, methadone maintenance, regulations, revision, FDA;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Gurtel, A. L.;
AU - Fallavollita, A.;
AU - Rockey, P. H.;
AU - Gleser, M. A.;
T1 - Computer assistance for the P&T committee
CT - Computer assistance for the P&T committee
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1980/10/01/
VL - 37
IS - Oct
SP - 1305
SN - 00029289
AD - U.S. Public Health Service Hosp., 1131 14th Ave., S., Seattle, WA 98114
N1 - Accession Number: 18-01322; Language: English; Chemical Name: Ticrynafen--40180-04-9; Therapeutic Class: (40:28); AHFS Class: Diuretics ticrynafen; Publication Type: Letters; Journal Coden: AJHPA9; Section Heading: Information Processing and Literature; Institutional Pharmacy Practice; Abstract Author: Joan Lentine
N2 - The decision to not include ticrynafen in a hospital formulary, based upon computer generated information, and the location of patients who had been treated with the drug following its recall from the market are discussed.
KW - Ticrynafen--drug information-;
KW - Drug information--ticrynafen--computers, hospital pharmacy, formulary and recall;
KW - Diuretics--ticrynafen--drug information, computers, hospital pharmacy, formulary and recall;
KW - Automation, data processing, computers--ticrynafen--drug information, hospital pharmacy, formulary and recall;
KW - Pharmacy, institutional, hospital--ticrynafen--drug information, computers, formulary and recall;
KW - Formularies--hospitals--ticrynafen, drug information, computers;
KW - Methodology--computers--hospitals, ticrynafen, drug information, formulary and recall;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Manders, David
AU - Harris, Patricia Roberts
T1 -
JO - New Republic
JF - New Republic
J1 - New Republic
PY - 1980/10/18/
Y1 - 1980/10/18/
VL - 183
IS - 16
M3 - Letter
SP - 3
EP - 40
SN - 00286583
AB - Presents letters to the editor referencing articles and topics discussed in previous issues. Criticism of the review by Herbert Gintis of the book "Inequality in an Age of Decline" in the September 6 issue; Arguments given by Patricia Roberts Harris, U.S. Secretary of Health and Human Services to defend herself against statements about her published in the September 27 issue; Comments on the nomination of Ronald Reagan for the presidential elections.
KW - LETTERS to the editor
KW - INEQUALITY in an Age of Decline (Book)
KW - GINTIS, Herbert
KW - HARRIS, Patricia, 1924-1985
KW - UNITED States. Dept. of Health & Human Services
KW - REAGAN, Ronald, 1911-2004
KW - PRESIDENTIAL candidates
KW - UNITED States
N1 - Accession Number: 11106403; Source Information: 10/18/80, Vol. 183 Issue 16, p3; Subject Term: LETTERS to the editor; Subject Term: INEQUALITY in an Age of Decline (Book); Subject Term: GINTIS, Herbert; Subject Term: HARRIS, Patricia, 1924-1985; Subject Term: UNITED States. Dept. of Health & Human Services; Subject Term: REAGAN, Ronald, 1911-2004; Subject Term: PRESIDENTIAL candidates; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 2p; ; Document Type: Letter;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
TY - GEN
AU - \AY/;
T1 - Toxic shock syndrome
CT - Toxic shock syndrome
JO - US Pharmacist (USA)
JF - US Pharmacist (USA)
Y1 - 1980/11/01/
VL - 5
IS - Nov-Dec
SP - 28
EP - 47
SN - 01484818
AD - Center for Disease Control, Public Health Service, Atlanta, GA
N1 - Accession Number: 19-02494; Language: English; References: 4; Journal Coden: USPHD5; Section Heading: Toxicity; Abstract Author: Salwa Rasmy
N2 - A review of toxic shock syndrome is presented and the roles of both Staphylococcus aureus and tampons in the pathogenesis of toxic shock syndrome in menstruating women are discussed. The isolation rates of \IT/S. aureus\OK/ in cases and controls document an association between \IT/S. aureus\OK/ and toxic shock syndrome. This association is consistent with an etiologic role for \IT/S. aureus\OK/ in this disease. It was concluded that there is a significant association between tampons and toxic shock syndrome in menstruating women and that the brand of tampon a woman uses is likely to affect her risk of developing toxic shock syndrome.
KW - Toxic shock syndrome--Staphylococcus aureus--role, and tampons, menstruating female patients, discussion;
KW - Staphylococcus aureus--toxic shock syndrome--role, and tampons, menstruating female patients, discussion;
KW - Toxicity--tampons--role, and S. aureus, toxic shock syndrome, menstruating female patients, discussion;
KW - Tampons--toxic shock syndrome--role, and S. aureus, menstruating female patients, discussion;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schmitt, Neal
AU - Colligan, Michael J.
AU - Fitzgerald, Michael
T1 - Unexplained physical symptoms in eight organizations: Individual and organizational analysis.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1980/12//
VL - 53
IS - 4
M3 - Article
SP - 305
EP - 317
PB - Wiley-Blackwell
SN - 03058107
AB - Data collected from 826 people in eight American organizations concerning mass reports of symptoms and various possible indicants of stress were subjected to correlational and regression analyses. In addition, using the argument that illness was actually an organizational phenomenon, company means of 41 predictor variables were correlated with company means on the symptoms variable. The three sets of analyses indicate that reported symptoms are related to work pressure, employee income, family disharmony and dissatisfaction with company personnel practices. Limitations of the data collection effort are noted and recommendations for future investigations are made. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - INDUSTRIAL psychology
KW - WORK -- Psychological aspects
KW - CORRELATION (Statistics)
KW - REGRESSION analysis
KW - INCOME
KW - STRESS (Psychology)
N1 - Accession Number: 4618974; Schmitt, Neal 1; Colligan, Michael J. 2; Fitzgerald, Michael 1; Affiliations: 1: Michigan State University; 2: National Institute for Occupational Safety and Health; Issue Info: Dec80, Vol. 53 Issue 4, p305; Thesaurus Term: JOB stress; Thesaurus Term: INDUSTRIAL psychology; Thesaurus Term: WORK -- Psychological aspects; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: REGRESSION analysis; Thesaurus Term: INCOME; Subject Term: STRESS (Psychology); Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hackleman, Edwin C.
T1 - FOOD LABEL INFORMATION: WHAT CONSUMERS SAY THEY WANT AND WHAT THEY NEED.
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 1981/01//
VL - 8
IS - 1
M3 - Article
SP - 477
EP - 483
PB - Association for Consumer Research
SN - 00989258
AB - This paper addresses the problem of isolating the important nutrient information desired by consumers on the food label. Since consumers have been criticized for their lack of nutrition knowledge, subject areas for additional learning are studied, and personal profiles based on learning interests are developed. Finally, comparisons between nutritional expert groups and household food buyers are made on the basis of desired nutrient information. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - CONSUMER education
KW - CONSUMER research
KW - FOOD industry
KW - CONSUMER behavior
KW - CONSUMERS
KW - NUTRITION
KW - HOUSEHOLDS
N1 - Accession Number: 6430614; Hackleman, Edwin C. 1; Affiliations: 1: Food and Drug Administration; Issue Info: 1981, Vol. 8 Issue 1, p477; Thesaurus Term: FOOD labeling; Thesaurus Term: CONSUMER education; Thesaurus Term: CONSUMER research; Thesaurus Term: FOOD industry; Thesaurus Term: CONSUMER behavior; Thesaurus Term: CONSUMERS; Subject Term: NUTRITION; Subject Term: HOUSEHOLDS; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 7p; Illustrations: 9 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Vandenberg, Robert J.
T1 - FOOD LABEL INFORMATION: WHAT CONSUMERS SAY THEY USE AND WHAT THEY ACTUALLY USE.
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 1981/01//
VL - 8
IS - 1
M3 - Article
SP - 484
EP - 487
PB - Association for Consumer Research
SN - 00989258
AB - The purpose of this study was to assess the following question: Do consumers' self-reports of food label use correspond with what they actually use? Evidence provided here suggests they do. However, the extent of usage of specific information components of the food label (e.g., the ingredients list, the nutrition label, etc.) is dependent on individual differences. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - LABELS
KW - CONSUMER education
KW - CONSUMER research
KW - FOOD industry
KW - CONSUMER behavior
KW - CONSUMERS
KW - NUTRITION
KW - INDIVIDUAL differences
N1 - Accession Number: 6430615; Vandenberg, Robert J. 1; Affiliations: 1: Food and Drug Administration and The University of Georgia; Issue Info: 1981, Vol. 8 Issue 1, p484; Thesaurus Term: FOOD labeling; Thesaurus Term: LABELS; Thesaurus Term: CONSUMER education; Thesaurus Term: CONSUMER research; Thesaurus Term: FOOD industry; Thesaurus Term: CONSUMER behavior; Thesaurus Term: CONSUMERS; Subject Term: NUTRITION; Subject Term: INDIVIDUAL differences; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Stewart, Michael L.
T1 - COMMERCIAL MARKET TRACKING SYSTEMS: APPLICATIONS TO POLICY FORMATION REGARDING NUTRITION LABELING.
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 1981/01//
VL - 8
IS - 1
M3 - Article
SP - 488
EP - 492
PB - Association for Consumer Research
SN - 00989258
AB - The first part of this paper describes the construction of a data base integrating retail market share and food package information for a sample of packaged processed foods. The data base was then employed to estimate the extent of nutrition labeling in the retail food market as well as the amount of nutrition labeling carried out voluntarily and the degree to which food manufacturers were violating the food labeling regulation by not including a nutrition label where required. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - FOOD -- Packaging
KW - RETAIL industry
KW - MARKET share
KW - COMMERCIAL markets
KW - CONSUMER education
KW - CONSUMER research
KW - FOOD industry
KW - NUTRITION
KW - PROCESSED foods
N1 - Accession Number: 6430616; Stewart, Michael L. 1; Affiliations: 1: Food and Drug Administration; Issue Info: 1981, Vol. 8 Issue 1, p488; Thesaurus Term: FOOD labeling; Thesaurus Term: FOOD -- Packaging; Thesaurus Term: RETAIL industry; Thesaurus Term: MARKET share; Thesaurus Term: COMMERCIAL markets; Thesaurus Term: CONSUMER education; Thesaurus Term: CONSUMER research; Thesaurus Term: FOOD industry; Subject Term: NUTRITION; Subject Term: PROCESSED foods; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 452999 All other miscellaneous general merchandise stores; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Schucker, Raymond E.
T1 - IMPLEMENTATION OF A REVISED FOOD LABELING POLICY: EVALUATION AND TRACKING.
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 1981/01//
VL - 8
IS - 1
M3 - Article
SP - 493
EP - 496
PB - Association for Consumer Research
SN - 00989258
AB - The paper reviews the environment in which FDA is revising the food labeling regulations regarding nutrition information and ingredients. The problem of raising the salience of nutrition to the public is discussed from education and marketing perspectives. FDA plans are outlined for introductory consumer education on how to use the new label, including the need for evaluative research and market tracking of the rate of new label adoption by the food industry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - LABELS
KW - CONSUMER education
KW - CONSUMER research
KW - FOOD industry
KW - MARKETING
KW - NUTRITION
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 6430617; Schucker, Raymond E. 1; Affiliations: 1: Food and Drug Administration; Issue Info: 1981, Vol. 8 Issue 1, p493; Thesaurus Term: FOOD labeling; Thesaurus Term: LABELS; Thesaurus Term: CONSUMER education; Thesaurus Term: CONSUMER research; Thesaurus Term: FOOD industry; Thesaurus Term: MARKETING; Subject Term: NUTRITION; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 541613 Marketing Consulting Services; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1982-21289-001
AN - 1982-21289-001
AU - Klerman, Gerald L.
T1 - The spectrum of mania.
JF - Comprehensive Psychiatry
JO - Comprehensive Psychiatry
JA - Compr Psychiatry
Y1 - 1981/01//Jan-Feb, 1981
VL - 22
IS - 1
SP - 11
EP - 20
CY - Netherlands
PB - Elsevier Science
SN - 0010-440X
SN - 1532-8384
N1 - Accession Number: 1982-21289-001. PMID: 7460559 Partial author list: First Author & Affiliation: Klerman, Gerald L.; US Dept of Health & Human Services, Public Health Service, Rockville, MD. Release Date: 19820701. Correction Date: 20160407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Etiology; Mania; Psychodiagnostic Typologies; Psychopathology. Minor Descriptor: Drug Therapy; Epidemiology; Lithium. Classification: Affective Disorders (3211). Population: Human (10). Page Count: 10. Issue Publication Date: Jan-Feb, 1981.
AB - Points out that during the last 2 decades, several major scientific advances have contributed to the understanding of mania: (1) the advent of psychotherapeutic agents, (2) the renaissance of interest in psychopathology and diagnosis, (3) emphasis on biological and genetic etiologic factors, and (4) the growth of psychiatric epidemiology. The spectrum of mania or 'elations' runs the gamut from normal states of happiness, joy, and pleasure to extremes of delirious mania in which the patient may be 'maniacal,' markedly excited, hostile and assaultive, or paranoid and delusional. The distinction between mania as a state (or episode) and mania as a disorder (in which the term bipolar disorder is used) is made. The study of mania is currently focused on the process of recognizing, identifying, and classifying the heterogeneous types of bipolar disorder. Efforts have been made to separate different diagnostic groups into subgroups of greater homogeneity, but debate continues as to whether it is best to split the subtypes of a disorder according to specified criteria or lump them together in a more general category. (30 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathology & diagnosis & lithium therapy & etiology & epidemiology & symptoms
KW - mania & manic depression
KW - 1981
KW - Bipolar Disorder
KW - Etiology
KW - Mania
KW - Psychodiagnostic Typologies
KW - Psychopathology
KW - Drug Therapy
KW - Epidemiology
KW - Lithium
KW - 1981
DO - 10.1016/0010-440X(81)90049-3
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1982-12893-001
AN - 1982-12893-001
AU - Burns, Thomas R.
T1 - A survey of attitudes toward alcoholics and alcohol programs among Indian Health Service personnel.
JF - White Cloud Journal of American Indian/Alaska Native Mental Health
JO - White Cloud Journal of American Indian/Alaska Native Mental Health
Y1 - 1981///
VL - 2
IS - 3
SP - 25
EP - 30
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0190-2482
N1 - Accession Number: 1982-12893-001. Other Journal Title: American Indian and Alaska Native Mental Health Research; White Cloud Journal of American Indian Mental Health. Partial author list: First Author & Affiliation: Burns, Thomas R.; Indian Health Service, Phoenix Area Office, AZ. Release Date: 19820601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Attitudes; Alcohol Rehabilitation; Alcoholism; American Indians; Physicians. Minor Descriptor: Nurses; Psychologists; Social Workers. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 6. Issue Publication Date: 1981.
AB - Surveyed 50 health professionals in the Phoenix area of the US Indian Health Service to find out their attitudes toward American Indian alcoholics and their service unit's alcoholism treatment program. Ss completed a 5-page questionnaire which showed that, as a group, they felt slightly positive about their program and slightly less positive about their clients. Results were correlated across the professions of physician, social worker, and nurse. (7 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attitudes toward American Indian alcoholics & alcohol program
KW - US Indian Health Service physicians vs nurses vs psychologists vs social workers
KW - 1981
KW - Alcohol Drinking Attitudes
KW - Alcohol Rehabilitation
KW - Alcoholism
KW - American Indians
KW - Physicians
KW - Nurses
KW - Psychologists
KW - Social Workers
KW - 1981
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kingon, Robert J.
AU - Wiesner, Paul J.
T1 - Premarital Syphilis Screening: Weighing the Benefits.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/02//
VL - 71
IS - 2
M3 - Article
SP - 160
EP - 162
PB - American Public Health Association
SN - 00900036
AB - This article discusses issues regarding the mandatory premarital syphilis screening in the U.S. State health authorities are deliberating on whether to retain, repeal or modify requirements for the premarital law. The main argument of most proponents of repeal deals with the lack of cost effectiveness of premarital screening and suggests the consideration of more effective syphilis control activities. However, in making an informed decision, the state policymaker should consider the benefits of a premarital serologic tests which include the detection and prevention of early syphilis and detection of latent disease and prevention of complications.
KW - Cost analysis
KW - Premarital examinations
KW - Syphilis -- Diagnosis
KW - Medical screening
KW - Diagnostic services
KW - United States
N1 - Accession Number: 4948005; Kingon, Robert J. 1; Wiesner, Paul J. 2; Affiliations: 1: Chief, Program Development Section, VD Control Division, BSS, CDC, Atlanta; 2: Director, Venereal Disease Control Division, Bureau of State Services, Center for Disease Control, U.S. Department of Health & Human Services, Public Health Service, Atlanta, GA 30333; Issue Info: Feb1981, Vol. 71 Issue 2, p160; Thesaurus Term: Cost analysis; Subject Term: Premarital examinations; Subject Term: Syphilis -- Diagnosis; Subject Term: Medical screening; Subject Term: Diagnostic services; Subject: United States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Stimson, J. B.;
AU - Hale, J.;
AU - Bowie, W. R.;
AU - Holmes, K. K.;
T1 - Tetracycline-resistant Ureaplasma urealyticum: cause of persistent nongonococcal urethritis
CT - Tetracycline-resistant Ureaplasma urealyticum: cause of persistent nongonococcal urethritis
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1981/02/01/
VL - 94
IS - Feb
SP - 192
EP - 194
SN - 00034819
AD - Div. of Infectious Diseases, U.S. Public Health Service Hosp., 1131 14th Ave. S., Seattle, WA 98114
N1 - Accession Number: 18-04290; Language: English; Chemical Name: Minocycline--10118-90-8 Tetracycline hydrochloride--64-75-5; Therapeutic Class: (8:12); AHFS Class: Antibiotics minocycline; References: 14; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Microbiology; Drug Evaluations
N2 - Two hundred eighty-nine men with nongonococcal urethritis in a randomized, double-blind study were tested with minocycline, 100 mg once or twice daily for 7 or 21 days. \IT/Ureaplasma urealyticum\OK/ was isolated before treatment from 167 (58%). The pretherapy isolates from 82 men re-examined 6 to 8 days after initiation of treatment were viable. In 6 (7%), isolates were resistant to 256 \mu/g/ml or more of tetracycline (I). Tetracycline resistance was significantly correlated with persistence of \IT/U. urealyticum\OK/ and persistence of nongonococcal urethritis during treatment. Recurrence of nongonococcal urethritis after initial resolution and recurrence of \IT/U. urealyticum\OK/ after interim negative cultures were not correlated with I resistance of \IT/U. urealyticum.\OK/ It was concluded that I resistant strains of \IT/U. urealyticum\OK/ are a cause of persistent but not of recurrent nongonococcal urethritis.
KW - Minocycline--urethritis-;
KW - Tetracycline hydrochloride--resistance-;
KW - Antibiotics--minocycline--urethritis, nongonococcal, U. urealyticum, tetracycline resistant, therapy, patients;
KW - Resistance--tetracycline hydrochloride--U. urealyticum, nongonococcal urethritis, minocycline therapy, patients;
KW - Ureaplasma urealyticum--resistance--tetracycline hydrochloride, nongonococcal urethritis, minocycline therapy, patients;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Pearson, D. J.
AU - Green, F. H. Y.
AU - Mentnech, Sharon M.
T1 - Soluble and particulate activators of complement and granulomatous pulmonary reactions.
JO - Clinical Allergy: Journal of the British Allergy Society
JF - Clinical Allergy: Journal of the British Allergy Society
Y1 - 1981/03//
VL - 11
IS - 2
M3 - Article
SP - 111
EP - 119
SN - 00099090
AB - In order to test the hypothesis that the histological changes of extrinsic allergic alveolitis result from non-specific activation of the complement cascade we studied pulmonary reactions to equivalent doses of soluble and particulate activators of complement in rats. A single intratracheal instillation of zymosan, a particulate activator of the complement system, produced a florid granulomatous pneumonitis which was maximal at 5 days. This granulomatous reaction did not appear to be associated with the development of hypersensitivity to zymosan. Complement depletion by cobra venom factor did not suppress the granulomatous reaction. Equivalent doses of soluble activators of complement failed to produce any inflammatory changes in the lung. Large doses of immune complex produced an acute, complement dependent, haemorrhagic alveolitis which was maximal at 8 hr and which resolved completely by 48 hr. We conclude that the late granulomatous pulmonary reaction to intra-tracheally administered zymosan is not due to an immune response, or a consequence of direct activation of the alternative pathway of complement, but is of 'foreign body' type. We urge caution in drawing conclusions regarding the pathogenesis of the allergic alveolitides on histological appearances alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Allergy: Journal of the British Allergy Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTOLOGY
KW - HYPERSENSITIVITY pneumonitis
KW - PLASMINOGEN activators
KW - CHRONIC granulomatous disease
KW - ZYMOSAN
N1 - Accession Number: 16222628; Pearson, D. J. 1,2; Green, F. H. Y. 2; Mentnech, Sharon M. 2; Source Information: Mar1981, Vol. 11 Issue 2, p111; Subject: HISTOLOGY; Subject: HYPERSENSITIVITY pneumonitis; Subject: PLASMINOGEN activators; Subject: CHRONIC granulomatous disease; Subject: ZYMOSAN; Number of Pages: 9p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Holt, Francis X.
T1 - SO YOU SAY YOU'RE A PROFESSIONAL?
JO - RN
JF - RN
Y1 - 1981/03//
VL - 44
IS - 3
M3 - Article
SP - 81
EP - 84
SN - 00337021
AB - Describes the characteristics of the nursing profession. Description of nursing wages; Discussion on nursing leadership; Difference between nursing preparation and nursing practice.
KW - NURSING -- Vocational guidance
KW - NURSING -- Practice
KW - LEADERSHIP
KW - PROFESSIONS
N1 - Accession Number: 5130924; Holt, Francis X. 1; Source Information: Mar81, Vol. 44 Issue 3, p81; Subject: NURSING -- Vocational guidance; Subject: NURSING -- Practice; Subject: LEADERSHIP; Subject: PROFESSIONS; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1431
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Byer, B
AU - Goetze, F
T1 - National drug code directory
JO - National drug code directory
JF - National drug code directory
Y1 - 1981/03/19/
M3 - Book
AB - Reel ntis02 is standard 1600 bpi tape which contains 229,557 variable length records. There are 4 record types: type 1 records contain basic information including the ndc, trade name, labeler, route of administration, dose form, etc; type 2 records contain information about packaging such as package code, type and size; type 3 records contain information about ingredient. The printed directory includes a minimum of 3 ingredients. The data tape includes all active ingredients; and type 4 records contain information about the drug class.
N1 - Accession Number: ISTA1803599; Byer, B 1; Goetze, F; Affiliations: 1 : Food And Drug Administration, Rockville, Md. Drug Listing Branch; Source Info: Mar. 19, 1981; Note: Update Code: 1800; Document Type: Book
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Temkin-Greener, Helena
AU - Kunitz, Stephen J.
AU - Broudy, David
AU - Haffner, Marlene
T1 - Surgical Fertility Regulation among Women on the Navajo Indian Reservation, 1972-1978.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/04//
VL - 71
IS - 4
M3 - Article
SP - 403
EP - 407
PB - American Public Health Association
SN - 00900036
AB - Abstract: Changes in the rates of induced abortions, bilateral tubal ligations, and hysterectomies on the Navajo Indian Reservation have been examined for the years 1972-1978. While the incidence of abortions and tubal sterilizations is still considerably lower among Navajo women than among the total United States population of women, it has risen, especially among those in the prime of the reproductive cycle, i.e., ages 20-34. The rate of hysterectomy has not changed substantially. Regression analyses performed on the data indicate that the utilization of surgery for fertility regulation in women on the Navajo Reservation, unlike other surgical procedures, is not affected by access to hospitals which provide surgery. Rather measures of involvement in the wage work economy are of primary importance. Those areas of the Reservation having the highest levels of such involvement exhibit the highest rates of such surgery. (Am J Public Health 1981: 71:403-407.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gynecologic surgery
KW - Navajo (North American people)
KW - Abortion
KW - Hysterectomy
KW - Sterilization of women
KW - Navajo Indian Reservation
N1 - Accession Number: 4954759; Temkin-Greener, Helena 1; Kunitz, Stephen J. 1; Broudy, David 2; Haffner, Marlene 2; Affiliations: 1: Department of Preventive, Family, and Rehabilitation Medicine, Box 644, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642; 2: Navajo Area Indian Health Service, Window Rock, AZ; Issue Info: Apr1981, Vol. 71 Issue 4, p403; Subject Term: Gynecologic surgery; Subject Term: Navajo (North American people); Subject Term: Abortion; Subject Term: Hysterectomy; Subject Term: Sterilization of women; Subject: Navajo Indian Reservation; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kaminski, Rose
AU - Brockert, John
AU - Sestito, John
AU - Frazier, Todd
T1 - Occupational Information on Death Certificates: A Survey of State Practices.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/05//
VL - 71
IS - 5
M3 - Article
SP - 525
EP - 526
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national survey was conducted in 1979 to determine the extent to which state and local vital registration offices coded and stored occupational information reported on death certificates. This survey found that 11 states routinely code occupation, seven routinely code, industry and six have coded occupation and/or industry on a limited basis. Stale and federal cooperation is needed to facilitate increased of mortality data for environmental and occupational health research. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Industrial surveys
KW - Personal information management
KW - Occupations
KW - Death certificates
N1 - Accession Number: 4949353; Kaminski, Rose 1; Brockert, John 2,3; Sestito, John 1,2; Frazier, Todd 1,2; Affiliations: 1: Robert Taft Laboratories, NIOSH, 4676 Columbia Park-way, Cincinnati, OH 45226; 2: National Institute for Occupational Safety and Health, American Association for Vital Records and Public Health Statistics; 3: Utah State Health Department; Issue Info: May81, Vol. 71 Issue 5, p525; Thesaurus Term: Industrial hygiene; Subject Term: Industrial surveys; Subject Term: Personal information management; Subject Term: Occupations; Subject Term: Death certificates; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1982-28664-001
AN - 1982-28664-001
AU - Soeken, Donald R.
AU - Manderscheid, Ronald W.
AU - Flatter, Charles H.
AU - Silbergeld, Sam
T1 - A controlled study of quantitative feedback in married-couples brief group psychotherapy.
JF - Psychotherapy: Theory, Research & Practice
JO - Psychotherapy: Theory, Research & Practice
JA - Psychotherapy (Chic)
Y1 - 1981///Sum 1981
VL - 18
IS - 2
SP - 204
EP - 216
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
N1 - Accession Number: 1982-28664-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research, Practice, Training. Partial author list: First Author & Affiliation: Soeken, Donald R.; US Public Health Service Outpatient Clinic, Washington, DC. Other Publishers: Educational Publishing Foundation. Release Date: 19821001. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Feedback; Group Psychotherapy; Psychotherapeutic Techniques; Spouses. Classification: Group & Family Therapy (3313). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Sum 1981. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1981.
AB - Investigated the impact of delayed, written feedback on the process and outcome of brief group psychotherapy for married couples using a 2-group, 2-stage design. 12 18–36 yr old heterosexual couples participated. Results show that (1) feedback variables showed more significant changes in expected directions than did the nonfeedback variables; (2) therapy plus feedback, in contrast to therapy alone, led to the assessment of greater behavioral change; (3) therapy plus feedback was a more effective tool than therapy alone for increasing the degree of congruence between self and peer ratings, and between self and therapist ratings. (28 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - delayed written feedback in brief group psychotherapy
KW - outcome
KW - 18–36 yr old spouses
KW - 1981
KW - Feedback
KW - Group Psychotherapy
KW - Psychotherapeutic Techniques
KW - Spouses
KW - 1981
DO - 10.1037/h0086081
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1982-28664-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Landrigan, Philip J.
AU - Gross, Richard L.
T1 - Chemical Wastes--Illegal Hazards and Legal Remedies.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/09//
VL - 71
IS - 9
M3 - Editorial
SP - 985
EP - 987
PB - American Public Health Association
SN - 00900036
AB - The author reflects on the health hazards caused by toxic wastes disposed of by chemical manufacturers. Some of these substances are carcinogens, neurotoxins and compounds capable of causing reproductive impairment. He suggested remedies of reducing occupational exposures to chemical wastes and controlling contamination of ground and surface waters.
KW - Hazardous wastes
KW - Chemical industry
KW - Public health
KW - Carcinogens
N1 - Accession Number: 4949601; Landrigan, Philip J. 1; Gross, Richard L. 2; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies; 2: Division of Criteria Documents and Standards Development National Institute for Occupational Safety and Health; Issue Info: Sep81, Vol. 71 Issue 9, p985; Thesaurus Term: Hazardous wastes; Thesaurus Term: Chemical industry; Thesaurus Term: Public health; Thesaurus Term: Carcinogens; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1983-24009-001
AN - 1983-24009-001
AU - Warren, Charles W.
AU - Smith, Jack C.
AU - Rochat, Roger W.
AU - Holck, Susan E.
T1 - Contraceptive sterilization: A comparison of Mexican-Americans and Anglos living in U.S. counties bordering Mexico.
JF - Biodemography and Social Biology
JO - Biodemography and Social Biology
JA - Biodemography Soc Biol
Y1 - 1981///Fal-Win 1981
VL - 28
IS - 3-4
SP - 265
EP - 280
CY - US
PB - Society for the Study of Social Biology
SN - 1948-5565
SN - 1948-5573
N1 - Accession Number: 1983-24009-001. Other Journal Title: Eugenics Quarterly. Partial author list: First Author & Affiliation: Warren, Charles W.; US Dept of Health & Human Services Public Health Service, Centers for Disease Control Ctr for Health Promotion & Education, Atlanta, GA. Release Date: 19830801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Birth Control; Cross Cultural Differences; Mexican Americans; Sterilization (Sex); Whites. Minor Descriptor: Demographic Characteristics; Human Sex Differences. Classification: Health & Mental Health Services (3370); Sexual Behavior & Sexual Orientation (2980). Population: Human (10). Page Count: 16. Issue Publication Date: Fal-Win 1981.
AB - Compared 859 female Mexican Americans with 620 female Anglos for (a) prevalence of contraceptive sterilization, (b) social and demographic characteristics of users of contraceptive sterilization, and (c) timing during the reproductive life cycle when contraceptive sterilization occurs. For both groups, contraceptive sterilization (male and female) was the 2nd most prevalent method used. Anglos were more likely to use male than female sterilization (22.4 and 19.5%, respectively), while Mexican Americans were much more likely to use female than male sterilization (23.2 and 5.8%, respectively). (21 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence & user demographic characteristics
KW - contraceptive sterilization
KW - male vs female Mexican Americans vs Anglos
KW - 1981
KW - Birth Control
KW - Cross Cultural Differences
KW - Mexican Americans
KW - Sterilization (Sex)
KW - Whites
KW - Demographic Characteristics
KW - Human Sex Differences
KW - 1981
DO - 10.1080/19485565.1981.9988463
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - DEUTSCH, EDWARD
AU - BUSHONG, WILLIAM
AU - GLAVAN, KENNETH A.
AU - ELDER, R. C.
AU - SODD, VINCENT J.
AU - SCHOLZ, KENNETH L.
AU - FORTMAN, DONALD L.
AU - LUKES, STEVEN J.
T1 - Heart Imaging with Cationic Complexes of Technetium.
JO - Science
JF - Science
Y1 - 1981/10/02/
VL - 214
IS - 4516
M3 - Article
SP - 85
EP - 86
SN - 00368075
AB - The cationic technetium-99 complex trans-[99TC(dmpe)2Cl2]+, where dmpe is bis(1,2-dimethylphosphino)ethane or (CH3)2P-CH2CH2-P(CH3)2, has been prepared and characterized by single-crystal, x-ray structural analysis. The technetium- 99m analog, trans-[99mTc(dmpe) 2Cl2]+, has also been prepared and shown to yield excellent gamma-ray images of the heart. The purposeful design, characterization, and synthesis of this technetium-99m radiopharmaceutical represents a striking application of fundamental inorganic chemistry to a problem in applied nuclear medicine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691888; DEUTSCH, EDWARD 1; BUSHONG, WILLIAM 1; GLAVAN, KENNETH A. 1; ELDER, R. C. 1; SODD, VINCENT J. 2; SCHOLZ, KENNETH L. 2; FORTMAN, DONALD L. 2; LUKES, STEVEN J. 2; Affiliations: 1: Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221; 2: Nuclear Medicine Laboratory, Bureau of Radiological Health, Food and Drug Administration, Cincinnati 45267; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p85; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BURGESS, A. E.
AU - WAGNER, R. F.
AU - JENNINGS, R. J.
AU - BARLOW, H. B.
T1 - Efficiency of Human Visual Signal Discrimination.
JO - Science
JF - Science
Y1 - 1981/10/02/
VL - 214
IS - 4516
M3 - Article
SP - 93
EP - 94
SN - 00368075
AB - We have measured the overall statistical efficiency of human subjects discriminating the amplitude of visual pattern signals added to noisy backgrounds. By changing the noise amplitude, the amount of intrinsic noise can be estimated and allowed for. For a target containing a few cycles of a spatial sinusoid of about 5 cycles per degree, the overall statistical efficiency is as high as 0.7 ± 0.07, and after correction for intrinsic noise, efficiency reaches 0.83 ± 0.15. Such a high figure leaves little room for residual inefficiencies in the neural mechanisms that handle these patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84691892; BURGESS, A. E. 1; WAGNER, R. F. 2; JENNINGS, R. J. 2; BARLOW, H. B. 3; Affiliations: 1: Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada V5Z IM9; 2: Division of Electronic Products, Bureau of Radiological Health, Food and Drug Administration, Rockville, Maryland 20857; 3: Physiological Laboratory, University of Cambridge, Cambridge, England CB2 3EG; Issue Info: 10/ 2/1981, Vol. 214 Issue 4516, p93; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bopp, C. A.;
AU - Wachsmuth, I. K.;
T1 - Luciferase assay to detect bacterial contamination of intravenous fluids
CT - Luciferase assay to detect bacterial contamination of intravenous fluids
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1981/11/01/
VL - 38
IS - Nov
SP - 1747
EP - 1750
SN - 00029289
AD - Enteric Diseases Lab. Sec., Cent. for Disease Control, Public Health Service, Dept. of Health and Human Services, Atlanta, GA 30333
N1 - Accession Number: 19-00001; Language: English; Chemical Name: Luciferase--61970-00-1 Luciferin--2591-17-5; Therapeutic Class: (44:00); AHFS Class: Enzymes luciferase; References: 11; Journal Coden: AJHPA9; Section Heading: Pharmaceutical Technology; Microbiology
N2 - The luciferase assay for adenosine triphosphate (ATP) was evaluated for its effectiveness in detecting bacterial contamination of IV fluids. Purified luciferase/luciferin was rehydrated, and twofold, threefold, and sixfold dilutions of the enzyme in buffer were evaluated. The ATP was hydrated with Tris buffer to provide stock solutions of 0.1 mg. For the assay procedure involving the quantification of ATP with the 3 dilutions of enzyme, a 0.5 ml quantity was pipetted into the assay vial with an equal amount of the ATP standard. The vial was swirled and placed immediately in the photometer for assay. To determine if a smaller amount of enzyme could be used per sample, ""micro,'' "semimicro,'' and ""macro'' assays were devised using standard concentrations of ATP and 1:2 dilutions of enzyme. A strain of \IT/Enterobacter aerogenes\OK/ was cultured and diluted in IV fluid for whole cell and lysed cell assays. Four 250 ml IV bags containing 5% dextrose and 0.2% sodium chloride injection were inoculated with the bacteria, and after 4 weeks at 25 \DG/C a sample of each was assayed. In the comparison of the 3 dilutions of the enzyme preparation, the counts per min for each ATP concentration decreased as the enzyme dilution increased. However, the minimum amount of ATP that could be detected was the same for all 3 dilutions of enzyme, approximately 3 \X/ 10\SU/5\BS/ \mu/g/ml. The lower sensitivity limit for the detection of ATP was the same for the macro and semimacro assays, although the counts per min were much lower. The lower limit of sensitivity was 10\SU/5\BS/ bacteria/ml if the cells were not lysed; however, lysis of cells increased the sensitivity of the assay to a lower limit of 10\SU/4\BS/ bacteria/ml. Assay of the inoculated IV bags clearly indicated that the presence of ATP corresponded with the colony counts, which indicated bacterial cell concentrations of 10\SU/6\BS/ cells/ml. The luciferase assay for ATP was found to be a rapid and reasonable sensitive technique for detecting bacterial contamination in IV fluid, even following long periods of incubation. This assay is much faster than the colony count method of determining contamination.
KW - Luciferase--analysis-;
KW - Luciferin--enzymes-;
KW - Analysis--microbiological--luciferase, contamination, IV injections;
KW - Contamination--injections--intravenous, analysis, luciferase;
KW - Injections--intravenous--contamination, analysis, microbiological, luciferase;
KW - Enzymes--luciferase--analysis, microbiological, contamination, IV injections;
KW - Tests--sterility--injections, IV, contamination, microbiological, luciferase analysis;
KW - Sterility--tests--injections, IV, contamination, microbiological, luciferase analysis;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Frattali, Victor P.
T1 - Reply to letter by Ayers et al.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1981/12//
VL - 34
IS - 12
M3 - Letter to the Editor
SP - 2857
EP - 2857
SN - 00029165
AB - A letter to the editor is presented in response to the article "Severe caloric restriction" by W. R. Ayers and colleagues published in a previous issue of the journal.
KW - Low-calorie diet
KW - Reducing diets
KW - Ayers, W. R.
N1 - Accession Number: 85607675; Frattali, Victor P. 1; Affiliations: 1: Division of Nutrition, Bureau of Foods, Food and Drug Administration, 200 C Street, SW, Washington, D.C. 20204; Issue Info: Dec1981, Vol. 34 Issue 12, p2857; Subject Term: Low-calorie diet; Subject Term: Reducing diets; People: Ayers, W. R.; Number of Pages: 1p; Document Type: Letter to the Editor
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LOVE, MILTON
AU - TEEBKEN-FISHER, DIXIE
AU - HOSE, Jo ELLEN
AU - FARMER III, J. J.
AU - HICKMAN, FRANCES W.
AU - FANNING, G. RICHARD
T1 - Vibrio damsela, a Marine Bacterium, Causes Skin Ulcers on the Damselfish Chromis punctipinnis.
JO - Science
JF - Science
Y1 - 1981/12/04/
VL - 214
IS - 4525
M3 - Article
SP - 1139
EP - 1140
SN - 00368075
AB - A previously undescribed marine bacterium, Vibrio damsela, was isolated from naturally occurring skin ulcers on a species of temperate-water damselfis)t, the blacksmith (Chromis punctipinnis). Laboratory infection of the blacksmith with Vibrio damsela produced similar ulcers. Vibrio damsela was pathogenic for four other species of damselfish but not for members of other families of fish. The bacterium has also been isolated from water and from two human wounds and may be a cause of human disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84704817; LOVE, MILTON 1; TEEBKEN-FISHER, DIXIE 2; HOSE, Jo ELLEN 1,3; FARMER III, J. J. 4; HICKMAN, FRANCES W. 4; FANNING, G. RICHARD 5; Affiliations: 1: Department of Biology, Occidental College, Los Angeles, California 90041; 2: Department of Vivaria and Pathology, University of Southern California, Los Angeles 90033; 3: Department of Pathology, University of Southern California; 4: Enteric Section, Centers for Disease Control, Public Health Service, Atlanta, Georgia 30333; 5: Department of Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012; Issue Info: 12/ 4/1981, Vol. 214 Issue 4525, p1139; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Christensen-Szalanski, Jay J. J.
AU - Diehr, Paula H.
AU - Wood, Robert W.
AU - Tompkins, Richard K.
T1 - Phased Trial of a Proven Algorithm At a New Primary Care Clinic.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/01//
VL - 72
IS - 1
M3 - Article
SP - 16
PB - American Public Health Association
SN - 00900036
AB - A previous study showed that a clinical algorithm for respiratory illnesses consisting of a checklist, a set of instructions (logic), and computer audit/feedback, could reduce costs significantly while maintaining a high quality of care. The results of this study show that the algorithm system, developed and validated at one primary care clinic can be successfully imported to another primary care clinic. In the present study, the algorithm system significantly improved the completeness of the medical records reduced the use of medical tests by 20 per cent-75 per cent and reduced non-provider costs by 36 per cent per patient visit. This study also shows that all three components of the algorithm system appear to he necessary to achieve these improvements and maintain a high quality of medical care. These results suggest that a wider use of the algorithm system for minor acute medical problems is both feasible and useful in providing high-quality cost-effective care that is audilable. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Cost effectiveness
KW - Medical protocols
KW - Medical informatics
KW - Cost control
KW - Primary care (Medicine)
KW - Medical records
KW - Medical care
KW - Computerized auditing
KW - Patients
KW - Caring
KW - Algorithms
N1 - Accession Number: 4949267; Christensen-Szalanski, Jay J. J. 1; Diehr, Paula H. 2; Wood, Robert W. 3; Tompkins, Richard K. 4; Affiliations: 1: Department of Health Services Research, United States Public Health Service Hospital, Seattle, Washington, University of Washington, Seattle.; 2: Department of Health Services, School of Public Health and Community Medicine, University of Washington, Seattle; 3: Department of Biostatistics, School of Public Health and Community Medicine, , University of Washington, Seattle.; 4: Department of Medicine, School of Medicine, University of Washington, Seattle.; Issue Info: Jan1982, Vol. 72 Issue 1, p16; Thesaurus Term: RESEARCH; Thesaurus Term: Cost effectiveness; Subject Term: Medical protocols; Subject Term: Medical informatics; Subject Term: Cost control; Subject Term: Primary care (Medicine); Subject Term: Medical records; Subject Term: Medical care; Subject Term: Computerized auditing; Subject Term: Patients; Subject Term: Caring; Subject Term: Algorithms; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jones, Lawrence
AU - Kwak, N.K.
T1 - A GOAL PROGRAMMING MODEL FOR ALLOCATING HUMAN RESOURCES FOR THE GOOD LABORATORY PRACTICE REGULATIONS.
JO - Decision Sciences
JF - Decision Sciences
Y1 - 1982/01//
VL - 13
IS - 1
M3 - Article
SP - 156
EP - 166
SN - 00117315
AB - The Food and Drug Administration's final Good Laboratory Practice regulation will have a far-reaching effect on testing laboratories that are conducting nonclinical laboratory safety tests. This paper develops a goal programming decision model suitable for setting objectives, meeting budgetary and operational constraints, planning personnel utilization, and evaluating different proposals for allocating laboratory personnel to implement a program. [ABSTRACT FROM AUTHOR]
AB - Copyright of Decision Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERSONNEL management
KW - INDUSTRIAL safety
KW - LABORATORY management
KW - UNITED States
KW - Goal Programming
KW - Manpower Planning
KW - Quality Control
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 5002513; Jones, Lawrence 1; Kwak, N.K. 2; Affiliations: 1: Deputy Director, National Center for Drug Analysis, Food and Drug Administration; 2: Professor of Management Sciences, St. Louis University; Issue Info: Jan1982, Vol. 13 Issue 1, p156; Thesaurus Term: PERSONNEL management; Thesaurus Term: INDUSTRIAL safety; Subject Term: LABORATORY management; Subject: UNITED States; Author-Supplied Keyword: Goal Programming; Author-Supplied Keyword: Manpower Planning; Author-Supplied Keyword: Quality Control ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; Number of Pages: 11p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hagebak, Beaumont R.
T1 - THE FORGIVENESS FACTOR: TAKING THE RISK OUT OF EFFORTS TO INTEGRATE HUMAN SERVICES.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1982/01//Jan/Feb82
VL - 42
IS - 1
M3 - Article
SP - 72
EP - 76
PB - Wiley-Blackwell
SN - 00333352
AB - During the past two decades, human services have enjoyed phenomenal expansion as measured by public expenditure and program growth. During fiscal year 1981 alone, the Department of Health and Human Services expended an estimated $229.1 billion-35 percent of the entire federal budget-on a host of categorical programs ranging from rat control to family planning. The growth of autonomous social programs continued even though the national economy began to stagger under the weight of double-digit inflation. With resources sharply reduced, state human service agencies face immediate needs for innovative redesign of their own categorical systems. Employing technologies already available to them, some state governments are certain to attempt consolidation of local delivery systems in the interest of cost effectiveness, to assure that those in greatest need continue to receive adequate care. Permission is a rare commodity in any hierarchy. The facts of bureaucratic risk-taking behavior do not favor the approval of innovative solutions.
KW - HUMAN services
KW - FISCAL policy
KW - INTERNATIONAL economic assistance
KW - BUDGET -- Law & legislation
KW - PUBLIC administration
KW - LOCAL government
N1 - Accession Number: 4597016; Hagebak, Beaumont R. 1; Affiliations: 1: U. S. Public Health Service.; Issue Info: Jan/Feb82, Vol. 42 Issue 1, p72; Thesaurus Term: HUMAN services; Thesaurus Term: FISCAL policy; Thesaurus Term: INTERNATIONAL economic assistance; Thesaurus Term: BUDGET -- Law & legislation; Thesaurus Term: PUBLIC administration; Thesaurus Term: LOCAL government; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 911420 International assistance; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Miller, Steve
AU - Shah, Mukhtar Ahmed
T1 - Cholinesterase activities of workers exposed to organophosphorus insecticides in Pakistan and Haiti and an evaluation of the tintometric method.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1982/01/02/
VL - 17
IS - 2
M3 - Article
SP - 125
EP - 142
SN - 03601234
AB - Five reference laboratories were established in Pakistan for monitoring cholinesterase (ChE) activities of workers exposed to organophosphorus compounds. ChE activities were determined by the Michel and tintometric method. Observations of ChE activities were made during two malaria seasons. The first season showed that although a significant depression of cholinesterase occurred among some of the workers, the ChE activities of workers were within the normal range during the following season≪ The reason for the difference is discussed. Similar studies were undertaken in Haiti. Mean and standard deviations (SD) were calculated for comparison of the tintometric versus the Michel method. The data show a correlation between the methods. For further evaluation of the tintometric method, organophosphorus and oxon analog inhibition of cholinesterase were determined in vitro. The tabulated data show that the tintometric method is adequate for determining whether a worker is exposed to dangerous amounts of insecticides. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75452592; Miller, Steve 1; Shah, Mukhtar Ahmed 2; Affiliations: 1: Vector Biology and Control Division, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U. S. Department of Health and Human Services, Atlanta, Georgia, 30333; 2: Malaria Control Center, Lahore, Pakistan; Issue Info: Jan1982, Vol. 17 Issue 2, p125; Number of Pages: 18p; Document Type: Article
L3 - 10.1080/03601238209372307
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1982-24586-001
AN - 1982-24586-001
AU - Smith, Michael J.
AU - Colligan, Michael J.
AU - Tasto, Donald L.
T1 - Health and safety consequences of shift work in the food processing industry.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 1982/02//
VL - 25
IS - 2
SP - 133
EP - 144
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
N1 - Accession Number: 1982-24586-001. PMID: 7200870 Partial author list: First Author & Affiliation: Smith, Michael J.; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control, Cincinnati, OH. Release Date: 19820801. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Absenteeism; Health; Occupational Safety; Skilled Industrial Workers; Workday Shifts. Minor Descriptor: Consequence. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Page Count: 12. Issue Publication Date: Feb, 1982.
AB - Employed both a survey and an evaluation of health and safety records to investigate the health and safety consequences of day vs afternoon, night, and rotating shifts for approximately 1,000 food-processing workers. Relative to the day workers, those on shift work, particularly rotating and night shifts, showed greater adverse effects. These included poorer sleep, altered eating habits, greater alcohol consumption, greater incidence of sick absence, and greater incidence of work-related injuries. Shift work was not related to self-reported health complaints or self-reported chronic disease states. The impact of shift work on sick absence and work-related injuries differed depending on worker sex, age, and work tenure. (French abstract) (14 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - days vs afternoon vs night vs rotating shift
KW - health & safety
KW - food processing workers
KW - 1982
KW - Employee Absenteeism
KW - Health
KW - Occupational Safety
KW - Skilled Industrial Workers
KW - Workday Shifts
KW - Consequence
KW - 1982
DO - 10.1080/00140138208924933
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Larkin, Edward P.
AU - Hunt, Daniel A.
T1 - Bivalve Mollusks: Control of Microbiological Contaminants.
JO - BioScience
JF - BioScience
Y1 - 1982/03//
VL - 32
IS - 3
M3 - Article
SP - 193
EP - 197
SN - 00063568
AB - Voluntary cooperation between the shellfish industry and government agencies has reduced the incidence of shellfishborne disease. Contamination of bivalve mollusks by bacterial pathogens, viruses, and toxin-containing phytoplankton is controlled by harvesting shellfish only from approved waters and by the use of sanitary food-handling practices. (Accepted for publication 12 October 1981) [ABSTRACT FROM AUTHOR]
AB - Copyright of BioScience is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Communicable diseases
KW - Pathogenic microorganisms
KW - Phytoplankton
KW - Microorganisms
KW - Bivalves
KW - Shellfish industry
KW - Government agencies
N1 - Accession Number: 28051429; Larkin, Edward P. 1; Hunt, Daniel A. 2; Affiliations: 1 : Virology Branch in the Division of Microbiology, Bureau of Foods, Food and Drug Administration, 1090 Tusculum Ave., Cincinnati, OH 45226; 2 : Shellfish Sanitation in the Division of Microbiology, Bureau of Foods, Food and Drug Administration, 1090 Tusculum Ave., Cincinnati, OH 45226; Source Info: Mar1982, Vol. 32 Issue 3, p193; Thesaurus Term: Foodborne diseases; Thesaurus Term: Communicable diseases; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Phytoplankton; Thesaurus Term: Microorganisms; Subject Term: Bivalves; Subject Term: Shellfish industry; Subject Term: Government agencies; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4835
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Rodgers, Jack
T1 - APL-STAT: A Do-It-Yourself Guide to Computational Statistics Using APL (Book).
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1982/03//
VL - 77
IS - 377
M3 - Book Review
SP - 222
SN - 01621459
AB - Reviews the book "APL-STAT: A Do-It-Yourself Guide to Computational Statistics Using APL," by James B. Ramsey and Gerald I. Musgrave.
KW - STATISTICS
KW - NONFICTION
KW - RAMSEY, James
KW - RAMSEY, James B.
KW - MUSGRAVE, Gerald
KW - MUSGRAVE, Gerald I.
KW - APL-STAT (Book)
N1 - Accession Number: 4604026; Rodgers, Jack 1; Affiliations: 1: U.S. Public Health Service.; Issue Info: Mar1982, Vol. 77 Issue 377, p222; Thesaurus Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: APL-STAT (Book); People: RAMSEY, James; People: RAMSEY, James B.; People: MUSGRAVE, Gerald; People: MUSGRAVE, Gerald I.; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Snippe, H.
AU - Van Houte, A. J.
AU - Janssen, A.
AU - Lizzio, Elaine F.
AU - Willers, J. M. N.
AU - Merchant, B.
T1 - Characterization of immunogenic properties of haptenated liposomal model membranes in mice VII. SYNERGISTIC RESPONSES TO HAPTENATED LIPOSOMES AND HAPTENATED THYMUS-DEPENDENT ANTIGENS IN CBA/N MICE.
JO - Immunology
JF - Immunology
Y1 - 1982/04//4/1/82
VL - 45
IS - 4
M3 - Article
SP - 613
EP - 620
SN - 00192805
AB - CBA/N mice have an X-linked S-cell defect which prevents them from responding to non- mitogenic thymus-independent (T1-2) antigens such as haptenated Ficoll. The CBA/N mice do, however, respond to another group of thymus-independent (TI-2) antigens among which are haptenated liposomes. The F1 male progeny of CBA/N female mice express the same characteristics. Hapten-specific plaque-forming cell (PFC) responses to haptenated proteins (thymus-dependent, TD, antigens) by CSA/N mice and CBA/N × C3H/HeN F1 male mice can be blocked by concomitant exposure to TI-2 antigens bearing the same hapten. Simultaneous exposure to haptenated liposomes (TI- I antigen) and TD antigens, however, results in a synergistic response to the hapten if the antigens share common epitopes. The tripeptide-enlarged hapten dinitrophenyl-β-alanylgly- cylglycine (J), conjugated to phosphatidyl-ethanol- amine (PE) and incorporated into liposomal model membranes, was used throughout the experiments. In F1 male mice the moderate responses to TD antigens could be restored to values equivalent to those seen in F1 female mice. This adjuvant effect of haptenated liposomes is hapten-specific, time-dependent, and restricted to certain structural forms of the liposomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - ANTIGENS
KW - THYMUS
KW - FICOLL
KW - LIPOSOMES
KW - DINITROBENZENES
N1 - Accession Number: 14004385; Snippe, H. 1; Van Houte, A. J. 1; Janssen, A. 1; Lizzio, Elaine F. 2; Willers, J. M. N. 1; Merchant, B. 2; Source Information: 4/1/82, Vol. 45 Issue 4, p613; Subject: MICE; Subject: ANTIGENS; Subject: THYMUS; Subject: FICOLL; Subject: LIPOSOMES; Subject: DINITROBENZENES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
T1 - Termination of Ventricular Tachycardia by Programmed Extrastimuli from an Externally-Activated Permanent Pacemaker.
AU - Greene, H. Leon
AU - Gross, Brian W.
AU - Preston, Thomas A.
AU - Werner, Jeffrey A.
AU - Kime, Gena M.
AU - Hessel, Eugene A.
AU - Weaver, W. Douglas
AU - Duncan, James L.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1982/05//
VL - 5
IS - 3
SP - 434
EP - 439
SN - 01478389
N1 - Accession Number: 17352288; Author: Greene, H. Leon: 1,2 Author: Gross, Brian W.: 1,2 Author: Preston, Thomas A.: 1,2 Author: Werner, Jeffrey A.: 1,2 Author: Kime, Gena M.: 1,2 Author: Hessel, Eugene A.: 1,2 Author: Weaver, W. Douglas: 1,2 Author: Duncan, James L.: 1,2 ; Author Affiliation: 1 Harborview Medical Center and United States Public Health Service Hospital, University of Washington, Seattle, Washington.: 2 Cordis Corporation, Miami, Florida.; No. of Pages: 6; Language: English; Publication Type: Article; Update Code: 20050621
N2 - Two patients with hemodynamically well-tolerated recurrent ventricular tachycardia, drug resistant and previously requiring numerous external electrical cardioversions, had a permanent pacemaker implanted which could be programmed lo deliver extrastimuli to convert the ventricular tachycardia to normal sinus rhythm. The patient- or physicianactivated device can he programmed to induce or terminate ventricular tachycardia with extrastimuli delivered at the predetermined intervals which consistently induced or terminated the arrhythmia in the electrophysiology laboratory, allowing repeated evaluation of drug regimens, The pacemaker has reliably, painlessly, and consistently induced and terminated repeated episodes of ventricular tachycardia. This programmable pacemaker offers an alternative therapy for patients with hemodynamically well-tolerated refractory ventricular tachycardia. ABSTRACT FROM AUTHOR
KW - *TACHYCARDIA
KW - *PATIENTS
KW - *THERAPEUTICS
KW - *ELECTROPHYSIOLOGY
KW - MEDICAL equipment
KW - RESEARCH
KW - cardioversion
KW - extrastimuli
KW - programmable pacemaker
KW - ventricular tachycardia
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Bienia, Richard A.
AU - VanderDecker, John D.
AU - Bienia, Baroline H.
T1 - Cuban Refugee Health Care: Response of the American Health Care System to the Unexpected Arrival of 125,000 Immigrants.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/06//
VL - 72
IS - 6
M3 - Article
SP - 594
EP - 596
PB - American Public Health Association
SN - 00900036
AB - During the spring of 1980, over 120,000 Cuban refugees emigrated to the United States. Their rapid, unexpected arrival overwhelmed existing health care facilities in south Florida. Government-operated screening centers capable of handling large patient loads were established. Health screening involved a brief history and physical examination and a search for active tuberculosis and venereal disease. Thousands of refugees were processed rapidly and released to waiting relatives and sponsors. Many others, who for social or psychological reasons could not be released, were transferred to holding centers in various parts of the country. US Public Health Service physicians were faced with difficulties whose basic cause could be traced to the boredom of camp life and stresses due to uncertainty regarding the future. Acting out and compliance problems with medical aftermaths were common. About 3,000 refugees remain in custody today. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Refugees
KW - Immigrants
KW - Medical care
KW - Health facilities
KW - Physicians
KW - Lung diseases
KW - Sexually transmitted diseases
KW - Mental fatigue
KW - HUMAN RESOURCES AND SOCIETY
N1 - Accession Number: 4949826; Bienia, Richard A. 1; VanderDecker, John D. 2,3; Bienia, Baroline H. 4; Affiliations: 1: Director, Primary Care Medicine Residency, Department of Medicine, Eastern Virginia Medical School, 600 Gresham Drive, Norfolk, VA 23501.; 2: Chief of Medicine, Public Health Service Hospital; 3: Associate Professor, Department of Medicine; 4: Director, Health Education and Training, PHS Hospital; Issue Info: Jun82, Vol. 72 Issue 6, p594; Thesaurus Term: Tuberculosis; Subject Term: Refugees; Subject Term: Immigrants; Subject Term: Medical care; Subject Term: Health facilities; Subject Term: Physicians; Subject Term: Lung diseases; Subject Term: Sexually transmitted diseases; Subject Term: Mental fatigue; Author-Supplied Keyword: HUMAN RESOURCES AND SOCIETY; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ribi, E.
AU - Granger, D. L.
AU - Milner, K. C.
AU - Yamamoto, K.
AU - Strain, S. M.
AU - Parker, R.
AU - Smith, R. W.
AU - Brehmer, W.
AU - Azuma, I.
T1 - Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.
JO - Immunology
JF - Immunology
Y1 - 1982/06//
VL - 46
IS - 2
M3 - Article
SP - 297
EP - 305
SN - 00192805
AB - Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIA
KW - TUBERCULOSIS
KW - ANTIGENS
KW - TUBERCULIN
KW - GRANULOMA
KW - IMMUNOLOGY
N1 - Accession Number: 13991040; Ribi, E. 1; Granger, D. L. 1; Milner, K. C. 1; Yamamoto, K. 2; Strain, S. M. 3; Parker, R. 3; Smith, R. W. 1; Brehmer, W. 4; Azuma, I. 2; Source Information: Jun82, Vol. 46 Issue 2, p297; Subject: MYCOBACTERIA; Subject: TUBERCULOSIS; Subject: ANTIGENS; Subject: TUBERCULIN; Subject: GRANULOMA; Subject: IMMUNOLOGY; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1984-18334-001
AN - 1984-18334-001
AU - Nystul, Michael S.
T1 - Self-maintenance: An intrapersonal dimension within Adlerian psychology.
JF - Individual Psychology: Journal of Adlerian Theory, Research & Practice
JO - Individual Psychology: Journal of Adlerian Theory, Research & Practice
JA - Individ Psychol
Y1 - 1982/06//
VL - 38
IS - 2
SP - 154
EP - 160
CY - US
PB - North American Society of Adlerian Psychology
SN - 0277-7010
N1 - Accession Number: 1984-18334-001. Other Journal Title: American Journal of Individual Psychology; Individual Psychologist; Journal of Individual Psychology; The Journal of Individual Psychology. Partial author list: First Author & Affiliation: Nystul, Michael S.; US Public Health Service Ft Defiance Indian Hosp, AZ. Other Publishers: American Society of Adlerian Psychology; University of Texas Press. Release Date: 19840701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Adjustment; Individual Psychology; Needs; Parent Educational Background. Classification: Interpersonal & Client Centered & Humanistic Therapy (3314). Population: Human (10). Page Count: 7. Issue Publication Date: Jun, 1982.
AB - Defines self-maintenance (SM) as an important intrapersonal psychological process and suggests ways for identifying and working with SM procedures. SM in children may be expressed as crying or emotional ventilation; it is the need for emotional equilibrium and also involves movement away from social (interpersonal) influences and toward autonomous need gratification, which takes place on 3 levels: physiological, psychological, and psychophysiological. A variety of procedures that a person can use to achieve SM on these 3 levels are outlined. Psychological implications of crying from an SM perspective are explored and illustrated with case examples. The examples show that parents' beliefs often blind them to their children's true SM needs and goals in crying, which often looks like misbehavior. It is concluded that parents' response to children's SM needs should involve giving the child time alone and offering support and counseling only if necessary. Parents may also enhance the SM process in children by encouraging them in reflection, contemplation, cognitive restructuring, meditation, relaxation techniques, jogging, crying, and other emotional ventilations. (10 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Adlerian-based self maintenance as intrapersonal process of need gratification
KW - parent education implications
KW - 1982
KW - Emotional Adjustment
KW - Individual Psychology
KW - Needs
KW - Parent Educational Background
KW - 1982
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1984-18333-001
AN - 1984-18333-001
AU - Nystul, Michael S.
T1 - Ten Adlerian parent–child principles applied to Navajos.
JF - Individual Psychology: Journal of Adlerian Theory, Research & Practice
JO - Individual Psychology: Journal of Adlerian Theory, Research & Practice
JA - Individ Psychol
Y1 - 1982/06//
VL - 38
IS - 2
SP - 183
EP - 189
CY - US
PB - North American Society of Adlerian Psychology
SN - 0277-7010
N1 - Accession Number: 1984-18333-001. Other Journal Title: American Journal of Individual Psychology; Individual Psychologist; Journal of Individual Psychology; The Journal of Individual Psychology. Partial author list: First Author & Affiliation: Nystul, Michael S.; US Public Health Service Indian Hosp, Ft Defiance, AZ. Other Publishers: American Society of Adlerian Psychology; University of Texas Press. Release Date: 19840701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Individual Psychology; Parent Child Relations; Parent Training; Sociocultural Factors. Classification: Interpersonal & Client Centered & Humanistic Therapy (3314). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 7. Issue Publication Date: Jun, 1982.
AB - Shares some of the author's experiences in attempting to start a parent education program on a Navajo reservation that would incorporate Adlerian parental principles having cross-cultural relevance. Several basic Adlerian beliefs already appear to be shared by many Navajos: mutual respect, social interest, and equality. Navajos value mutual respect in their society by demonstrating that everyone has value and a role. 10 principles having cross-cultural relevance to parenting are presented that were identified by Navajos as promoting positive parent–child relationships and not interfering with their cultural beliefs: (1) Give children opportunities to contribute, (2) be patient and understand them, (3) encourage them, (4) avoid conditional love, (5) believe in them, (6) encourage them to have friends, (7) have physical contact with them, (8) promote their physical health, (9) help them to feel safe, and (10) help them with their self-actualizing needs. Additional materials can be used to supplement the principles to provide a more comprehensive parent education program. The author concludes that there is a need to further develop cross-cultural parenting principles. (10 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cross cultural values & Adlerian principles
KW - development of parent education program
KW - Navajo Indians
KW - 1982
KW - American Indians
KW - Individual Psychology
KW - Parent Child Relations
KW - Parent Training
KW - Sociocultural Factors
KW - 1982
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1990-58749-001
AN - 1990-58749-001
AU - Meketon, Melvin J.
T1 - The integration of scientific and traditional healing in the Indian Health Service.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1982/06//
VL - 37
IS - 6
SP - 714
EP - 715
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1990-58749-001. Partial author list: First Author & Affiliation: Meketon, Melvin J.; US Public Health Service, Indian Health Service, Albuquerque, NM, US. Release Date: 19900101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Cross Cultural Differences; Folk Medicine; Health Care Delivery; Medical Model; Treatment. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jun, 1982. Copyright Statement: American Psychological Association. 1982.
AB - Comments on the article by H. Rappaport and M. Rappaport (see record [rid]1982-06242-001[/rid]) concerning African traditional healing and its relations with scientific practice and adds notes concerning the 26-yr relationship between western medicine, as practiced in the US Public Health Service, Indian Health Service and traditional Indian healers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - traditional concept of healing vs Western health delivery systems
KW - commentary
KW - 1982
KW - Cross Cultural Differences
KW - Folk Medicine
KW - Health Care Delivery
KW - Medical Model
KW - Treatment
KW - 1982
DO - 10.1037/0003-066X.37.6.714
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Littleton Jr., Preston A.
T1 - Toward a Theory of the Dental Care Market: A Critique.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/07//
VL - 72
IS - 7
M3 - Article
SP - 676
EP - 678
PB - American Public Health Association
SN - 00900036
AB - The primary contribution of Lipscomb and Douglass's1 interesting paper is to expand economists' traditionally narrow view of dentistry and the other health professions by identifying and attempting to incorporate important characteristics of the professions into a theoretical account of the dental care market. Four issues that the authors either identify or will encounter in the empirical testing of their model are addressed in this discussion. These are: I) the costs and benefits associated with both governmental regulation of the profession and self-imposed codes of professional conduct; 2) the dynamics of the ‘recent graduate-established dentist’ dichotomy; 3) the organizational hierarchy of the profession and its relative importance in controlling the dental care market; and 4) data limitations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Medicine
KW - Medical care
KW - Dentistry
KW - Dental care
KW - Medical personnel
KW - Professionalism
KW - Health maintenance organization medical offices
KW - Organizational structure
KW - Core competencies
N1 - Accession Number: 4950397; Littleton Jr., Preston A. 1; Affiliations: 1: Dental Consultant, Office of the Chief Dental Officer, Office of the Assistant Secretary of Health, US Public Health Service, DHHS, Washington, DC; Issue Info: Jul1982, Vol. 72 Issue 7, p676; Thesaurus Term: RESEARCH; Thesaurus Term: Medicine; Subject Term: Medical care; Subject Term: Dentistry; Subject Term: Dental care; Subject Term: Medical personnel; Subject Term: Professionalism; Subject Term: Health maintenance organization medical offices; Subject Term: Organizational structure; Subject Term: Core competencies; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stenberg, Carl W.
AU - Brunback, Gary B.
AU - McFee, Thomas S.
T1 - FROM MBO TO MBR.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1982/07//Jul/Aug82
VL - 42
IS - 4
M3 - Article
SP - 363
EP - 371
PB - Wiley-Blackwell
SN - 00333352
AB - The article emphasizes on a unique management approach of performance appraisal in organization for successful performance. This approach integrates performance appraisal into a broader performance management process and accounts for the two dimensions of performance, the individual's behaviors on the job and the results achieved. It is used at all levels of management from top to bottom. A prerequisite to successful reform is having convincing rationales for it. Goals and objectives provide the performer with initial direction and a source of motivating challenge, so, performance planning is considered to be the function most crucial for successful performance. A good plan, however, is useless without a sustained commitment to it. Monitoring is necessary to keep performance on track or to change the track, to facilitate progress reviews and other communication during the performance period, and to accumulate information for the appraisal. The purpose of performance reinforcement is to influence behavior and results through use of incentives.
KW - EMPLOYEES -- Rating of
KW - MANAGEMENT
KW - PERSONNEL management
KW - PERFORMANCE
KW - BEHAVIOR
KW - VIGILANCE (Psychology)
KW - Administrative Processes and Organizational Variables
N1 - Accession Number: 4596539; Stenberg, Carl W.; Brunback, Gary B. 1; McFee, Thomas S. 1; Affiliations: 1: US. Department of Health and Human Services.; Issue Info: Jul/Aug82, Vol. 42 Issue 4, p363; Thesaurus Term: EMPLOYEES -- Rating of; Thesaurus Term: MANAGEMENT; Thesaurus Term: PERSONNEL management; Subject Term: PERFORMANCE; Subject Term: BEHAVIOR; Subject Term: VIGILANCE (Psychology); Author-Supplied Keyword: Administrative Processes and Organizational Variables; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; Number of Pages: 9p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sullivan, Linda
AU - Smith, W. McFate
AU - Lynch, James J.
AU - Gisondi, Judith
AU - Leach, Mary Jane
AU - O'Brien, Terri A.
AU - Guffey, Teddylen
AU - Patton, Jewel Q.
AU - Sundin, Robert K.
AU - Heidrich, George
AU - Jasinkowski, Nancy
T1 - The RN Forum.
JO - RN
JF - RN
Y1 - 1982/07//
VL - 45
IS - 7
M3 - Article
SP - 7
EP - 102
SN - 00337021
AB - Discusses letters on nursing and medicine in the U.S. as of July 1982.
KW - NURSING
KW - MEDICINE -- United States
KW - UNITED States
N1 - Accession Number: 4935591; Sullivan, Linda; Smith, W. McFate 1; Lynch, James J.; Gisondi, Judith; Leach, Mary Jane; O'Brien, Terri A.; Guffey, Teddylen 2; Patton, Jewel Q. 3; Sundin, Robert K. 4; Heidrich, George 5; Jasinkowski, Nancy; Source Information: Jul82, Vol. 45 Issue 7, p7; Subject: NURSING; Subject: MEDICINE -- United States; Geographic Terms: UNITED States; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2016
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Attico, N. Burton
AU - Dales, Loring
AU - Chin, James
AU - Mann, Jonathan M.
AU - Montes, Jean
AU - Kenney, Michael L.
AU - MacLeod, Gordon K.
AU - Christopher Maxwell
AU - Rosenblum, Marcus M.
AU - Cotler, Miriam Piven
AU - Mumford, Emily
AU - Woods, Nancy F.
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/08//
VL - 72
IS - 8
M3 - Letter
SP - 855
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Public Health Implications of Rubella Antibody Levels in California," by L.G. Dales and J. Chin in the 1982 issue.
KW - VACCINATION
KW - Letters to the editor
KW - Rubella
N1 - Accession Number: 4949517; Attico, N. Burton 1; Dales, Loring 2; Chin, James 2; Mann, Jonathan M. 3; Montes, Jean 3; Kenney, Michael L.; MacLeod, Gordon K. 4; Christopher Maxwell 5; Rosenblum, Marcus M.; Cotler, Miriam Piven 6; Mumford, Emily 7; Woods, Nancy F. 8; Affiliations: 1: Area Maternal Health Consultant, DHHS/PHS/HSA, Phoenix Area Indian Health Service, Phoenix, AZ 85016-5981.; 2: Infectious Disease Section, California State Department of Health Services, 2151 Berkeley Way, Berkeley, CA 94704.; 3: Assistant Director, Health Promotion-Disease Prevention, Health Services Division, State of New Mexico, Santa Fe, NM 87503.; 4: Professor and Chairman, Department of Health Services Administration, University of Pittsburg, Graduate School of Public Health, Pittsburgh, PA 15261.; 5: Director, Respiratory Therapy, Commnunity Genera! Osteopathic Hospital, Harrisburg, PA 17105.; 6: Doctoral student, Health Services, UCLA Instructor, CSUN.; 7: Professor of Psychiatry and Preventive Medicine, University of Colorado, HeaIth Sciences Center, Denver, CO 80262.; 8: Associate Professor, Dept. of Psychological Nursing, School of Nursing, University of Washington, Seattle, WA 98195.; Issue Info: Aug1982, Vol. 72 Issue 8, p855; Thesaurus Term: VACCINATION; Subject Term: Letters to the editor; Subject Term: Rubella; Number of Pages: 5p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Rook, A. H.
AU - Djeu, Julie Y.
AU - Balow, J. E.
T1 - Natural killer cells and interferon responses in patients with systemic lupus erythematosus.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/08//
VL - 49
IS - 2
M3 - Article
SP - 239
EP - 245
SN - 00099104
AB - Natural killer (NK) cell activity was studied in 23 patients with systemic lupus erythematosus (SLE), The overall NK activity was lower in patients with SLE than in normal female individuals. Patients with clinically active SLE disease had slightly lower NK activity than the patients with inactive disease. Other clinical parameters as well as treatment status did not correlate with NK activity. Interferon (IFN) enhanced the NK activity of normal individuals and of 11 SLE patients, while it did not enhance in the remaining 12 patients. The patients whose NK activity was enhanced by β/IFN had significantly higher initial activity than those who did not respond to β/IFN. Furthermore, peripheral mononuclear cells (MNC) from IFN responders produced γ-IFN after stimulation with concanavalin A (Con A) in titres comparable to those of normals. In contrast, peripheral MNC from β-IFN non-responders failed to produce significant titres of γ-IFN after stimulation with Con A. These results indicate that certain patients with SLE have low NK activity, which is generally paralleled by an inability to respond to exogenous β-IFN and by blunted production of γ-IFN after stimulation with Con A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - SYSTEMIC lupus erythematosus
KW - INTERFERONS
KW - COLLAGEN diseases
KW - IMMUNOCOMPETENT cells
KW - AUTOIMMUNE diseases
N1 - Accession Number: 16252893; Tsokos, G. C. 1; Rook, A. H. 1; Djeu, Julie Y. 1; Balow, J. E. 1; Source Information: Aug1982, Vol. 49 Issue 2, p239; Subject: KILLER cells; Subject: SYSTEMIC lupus erythematosus; Subject: INTERFERONS; Subject: COLLAGEN diseases; Subject: IMMUNOCOMPETENT cells; Subject: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - KORNHAUSER, ANDRUA
AU - WAMER, WAYNE G.
AU - GILES JR., ALBERT L.
T1 - Psoralen Phototoxicity: Correlation with Serum and Epidermal 8-Methoxypsoralen and 5-Methoxypsoralen in the Guinea Pig.
JO - Science
JF - Science
Y1 - 1982/08/20/
VL - 217
IS - 4561
M3 - Article
SP - 733
EP - 735
SN - 00368075
AB - Serum and epidermal concentrations of 8-methoxypsoralen and 5- methoxypsoralen 2 hours after oral administration to guinea pigs were determined by high-performance liquid chromatography. A linear relation was found between the serum and epidermal concentrations of 8-methoxypsoralen. In addition, a relation was found between serum concentrations of 5-methoxypsoralen and 8-methoxypsoralen and the appearance ofphototoxicity. The lower phototoxicity of orally administered 5-methoxypsoralen as compared to 8-methoxypsoralen in the guinea pig appears to be due to its reduced concentrations in the epidermis, the primary site of the phototoxic events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84705895; KORNHAUSER, ANDRUA 1; WAMER, WAYNE G. 2; GILES JR., ALBERT L. 2; Affiliations: 1: Food and Drug Administration, Bureau of Foods, Division of Toxicology, Washington, D.C. 20204, and Harvard School of Dental Medicine, Boston, Massachusetts 00115; 2: Food and Drug Administration, Bureau of Foods, Division of Toxicology; Issue Info: 8/20/1982, Vol. 217 Issue 4561, p733; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1983-13210-001
AN - 1983-13210-001
AU - Nystul, Michael S.
T1 - The effects of systematic training for effective parenting on parental attitudes.
JF - The Journal of Psychology: Interdisciplinary and Applied
JO - The Journal of Psychology: Interdisciplinary and Applied
JA - J Psychol
Y1 - 1982/09//
VL - 112
IS - 1
SP - 63
EP - 66
CY - US
PB - Heldref Publications
SN - 0022-3980
SN - 1940-1019
N1 - Accession Number: 1983-13210-001. Partial author list: First Author & Affiliation: Nystul, Michael S.; Public Health Service Indian Hosp, Ft Defiance, AZ. Other Publishers: Taylor & Francis. Release Date: 19830601. Correction Date: 20140303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Parent Training; Parental Attitudes. Classification: Interpersonal & Client Centered & Humanistic Therapy (3314). Population: Human (10). Page Count: 4. Issue Publication Date: Sep, 1982.
AB - Administered the Attitude Toward the Freedom of Children Scale and the revised Parent Attitude Research Instrument to 28 23–50 yr old Australian mothers. 14 Ss attended a 9-wk course in Systematic Training for Effective Parenting (STEP), and the remaining 14 Ss were placed on a waiting list for the STEP program and acted as the control group. A 1-way ANOVA evaluated the effects of STEP on parental attitudes. Results show that STEP Ss (as compared to non-STEP Ss) were more democratic in their child-rearing attitudes, had a significantly higher tendency to encourage verbalization, and had a significantly lower tendency to be strict with their children. (12 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - systemic training for effective parenting
KW - parental attitudes
KW - 23–50 yr old mothers
KW - 1982
KW - Parent Training
KW - Parental Attitudes
KW - 1982
DO - 10.1080/00223980.1982.9923535
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1983-13112-001
AN - 1983-13112-001
AU - Brandt, Edward N.
T1 - Prevention policy and practice in the 1980s.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1982/09//
VL - 37
IS - 9
SP - 1038
EP - 1042
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1983-13112-001. PMID: 7149432 Partial author list: First Author & Affiliation: Brandt, Edward N.; US Dept of Health & Human Services, Public Health Service, Washington, DC. Release Date: 19830101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Behavior; Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 5. Issue Publication Date: Sep, 1982. Copyright Statement: American Psychological Association. 1982.
AB - Discusses the relationship between health habits and disease along every point of the human life span. The role of the individual, health professionals, and federal policy in dealing with personal health habits are also discussed. It is suggested that a climate must be created in the US in which all citizens can achieve not just 'good health,' but a sense of physical and psychological well-being that will allow them to realize their full human potential. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - need for focus of individuals & health professionals & federal policy on preventative promotion of better health behavior
KW - 1982
KW - Health Behavior
KW - Prevention
KW - 1982
DO - 10.1037/0003-066X.37.9.1038
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Bullock, W. E.
AU - Watson, Susan
AU - Nelson, K. E.
AU - Schauf, Victoria
AU - Makonkawkeyoon, S.
AU - Jacobson, R. R.
T1 - Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/10//
VL - 50
IS - 1
M3 - Article
SP - 105
EP - 114
SN - 00099104
AB - The capacity of peripheral blood mononuclear (PBM) cells from patients with leprosy to generate immunoglobulin-secreting cells in response to pokeweed mitogen (PWM) was evaluated by a reverse haemolytic plaque forming cell (PFC) assay. The PFC responses of PBM cells from patients with lepromatous (Lpr) leprosy were significantly higher (P<001) than those of PBM cells from normal controls and patients with tuberculoid leprosy. Co-culture of T lymphocytes from normal donors with PBM cells from Lpr patients reduced the PFC response of these cells to the normal range. T4+-helper lymphocytes from Lpr donors did not induce supranormal responses to PWM by normal PBM cells enriched for B lymphocytes. T8+-suppressor lymphocytes from normal donors greatly reduced the response of cultures containing normal allogeneic B cells plus T4+ cells. Conversely, when T8+ cells from Lpr donors were co-cultured with normal B cells plus T4+ cells, they failed to suppress the response to PWM. En summary, these studies have demonstrated abnormally high PWM-stimulated PFC responses by B lymphocytes from patients with Lpr leprosy. This aberration, in turn, is associated with a loss of regulatory function by T8+-suppressor cells in Lpr patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response -- Regulation
KW - LYMPHOCYTES
KW - LEPROSY
KW - MYCOBACTERIAL diseases
KW - LEUCOCYTES
KW - T cells
N1 - Accession Number: 16062881; Bullock, W. E. 1,2,3,4; Watson, Susan 1,2,3,4; Nelson, K. E. 1,2,3,4; Schauf, Victoria 1,2,3,4; Makonkawkeyoon, S. 1,2,3,4; Jacobson, R. R. 1,2,3,4; Source Information: Oct1982, Vol. 50 Issue 1, p105; Subject: IMMUNE response -- Regulation; Subject: LYMPHOCYTES; Subject: LEPROSY; Subject: MYCOBACTERIAL diseases; Subject: LEUCOCYTES; Subject: T cells; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1983-20565-001
AN - 1983-20565-001
AU - Sykes, Stephen M.
AU - Henton, Wendon W.
T1 - Control of wheel running by near-ultraviolet light.
JF - Physiology & Behavior
JO - Physiology & Behavior
JA - Physiol Behav
Y1 - 1982/11//
VL - 29
IS - 5
SP - 965
EP - 970
CY - Netherlands
PB - Elsevier Science
SN - 0031-9384
N1 - Accession Number: 1983-20565-001. PMID: 7156234 Partial author list: First Author & Affiliation: Sykes, Stephen M.; US Dept of Health & Human Services Public Health Service, Food & Drug Administration, Rockville, MD. Release Date: 19830701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Illumination. Minor Descriptor: Mice. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 6. Issue Publication Date: Nov, 1982.
AB - Compared wheel running by 8 male ICR mice during incandescent and incandescent plus near-ultraviolet (UV) illumination in 3 experiments. During the daily 12-hr light period, running rates decreased with supplemental UV compared to previous incandescent-only baselines. The decrements were systematically replicated in a 2nd experiment using alternating UV exposure and recovery phases programmed across blocks of sessions. Again, running rates consistently decreased with supplemental UV irradiation of Phases 2 and 4 compared to preceding baselines of Phases 1 and 3. In comparison, running rates were inconsistently affected during the 12-hr dark period in both experiments. A 3rd experiment compared the relative decremental effects of UV, blue, and red illumination. Baseline running rates monotonically decreased as an inverse function of wavelength for all Ss. Data suggest that the spectral composition of ambient illumination may affect behavior. (23 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - incandescent &/vs near-ultraviolet illumination
KW - wheel running
KW - male mice
KW - 1982
KW - Activity Level
KW - Illumination
KW - Mice
KW - 1982
DO - 10.1016/0031-9384(82)90353-5
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kaplan, Jonathan E.
AU - Feldman, Roger
AU - Campbell, Douglas S.
AU - Lookasaugh, Cindy
AU - Gary, G. William
T1 - The Frequency of a Norwalk-Like Pattern Of Illness in Outbreaks of Acute Gastroenteritis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/12//
VL - 72
IS - 12
M3 - Article
SP - 1329
PB - American Public Health Association
SN - 00900036
AB - Abstract: Records of 642 outbreaks of acute gastroenteritis were reviewed to determine the proportion of outbreaks that were clinically and epidemiologically consistent with Norwalk-like virus infection. Using as our criteria stool cultures negative for bacterial pathogens. mean (or median) duration of illness 12-60 hours, vomiting in is ≥ 50 per ¢ of cases, and, if known, mean (or median) incubation period of 24-48 hours, we found that 23 per ¢ of waterborne outbreaks. 4 per ¢ of foodborne outbreaks, and 67 per ¢, 60 per ¢, and 28 per ¢ of outbreaks in nursing homes, in summer camps, and on cruise ships. respectively, satisfied the criteria for Norwalk-like pattern. Of 54 outbreaks that satisfied the criteria for Norwalk-like pattern, 14 were investigated for virus etiology. Ten of these (71 per ¢) yielded serologic evidence of Norwalk-like virus infection. Norwalk-like viruses are probably an important cause of outbreaks of acute gastroenteritis, investigation for Norwalk virus antibody in outbreaks that are clinically and epidemiologically consistent with Norwalk-like virus infection ix likely to yield diagnostically useful results. (Am J Public Health 1982; 72: 1329-1332.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Pathogenic microorganisms
KW - Public health
KW - Diseases -- Causes & theories of causation
KW - Epidemiology
KW - Gastroenteritis
KW - Viral gastroenteritis
KW - Nursing care facilities
KW - Health facilities
KW - Older people
N1 - Accession Number: 4948804; Kaplan, Jonathan E. 1; Feldman, Roger 1; Campbell, Douglas S. 1; Lookasaugh, Cindy 1; Gary, G. William 1; Affiliations: 1: Viral and Bacterial Diseases Divisions (Atlanta, GA) and the Viral Enteritis and Hepatitis Division (Phoenix, AZ), Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services; Office of Public Health, New York State Department of Health, Albany, NY and the Pinellas County Health Department, St. Petersburg, FL; Issue Info: Dec1982, Vol. 72 Issue 12, p1329; Thesaurus Term: Virus diseases; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Public health; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Epidemiology; Subject Term: Gastroenteritis; Subject Term: Viral gastroenteritis; Subject Term: Nursing care facilities; Subject Term: Health facilities; Subject Term: Older people; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1983-25323-001
AN - 1983-25323-001
AU - Nystul, Michael S.
AU - Freedman, Donald
T1 - A youthful life-style for life.
JF - Journal of Humanistic Counseling, Education & Development
JO - Journal of Humanistic Counseling, Education & Development
JA - J Humanist Educ Dev
Y1 - 1982/12//
VL - 21
IS - 2
SP - 86
EP - 92
CY - US
PB - American Counseling Assn
SN - 0735-6846
N1 - Accession Number: 1983-25323-001. Partial author list: First Author & Affiliation: Nystul, Michael S.; US Dept of Health & Human Services, Public Health Service Indian Hosp, Ft Defiance, AZ. Release Date: 19830901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Exercise; Lifestyle; Self-Concept. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Page Count: 7. Issue Publication Date: Dec, 1982.
AB - Explores how an active life-style contributes to the quality of life and presents ideas that educators can use to help students develop an active life-style that will be of life-long value to them. The roles of parents and the family in encouraging an active life-style in their children, helping them develop a positive self-concept, and promoting their individuality are discussed. (13 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - active lifestyle
KW - quality of life & self concept
KW - children
KW - 1982
KW - Exercise
KW - Lifestyle
KW - Self-Concept
KW - 1982
DO - 10.1002/j.2164-4683.1982.tb00218.x
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Green, Lawrence W.
AU - Wilson, Ronald W.
AU - Bauer, Katherine G.
T1 - Data Requirements to Measure Progress on the Objectives for the Nation in Health Promotion and Disease Prevention.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/01//
VL - 73
IS - 1
M3 - Article
SP - 18
EP - 24
PB - American Public Health Association
SN - 00900036
AB - The Reagan Administration has adopted the policy guidelines developed over the previous few years in the disease prevention and health promotion initiative of the Carter Administration. Broad national consensus had been sought in the formulation of 226 measurable objectives for the decade. We classify the prevention objectives according to their position in an implied causal chain: 1) improved programs, 2) increased public and professional awareness, 3) reduced risk factors, and 4) improved health status. Prior to 1980, the data systems and periodic surveys sponsored by federal agencies and national organizations covered only four of the 42 objectives in the public and professional awareness category, whereas at least half of the objectives in each of the other three categories were covered by available national data sources, mostly federal. Sample surveys are needed to measure the majority of the currently unmeasured objectives in all four categories. Private and state health interview surveys are needed to supplement the federal capacity, especially in the face of federal cutbacks in survey capacity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical policy
KW - Presidents
KW - Government agencies
KW - Health promotion
KW - Preventive medicine
KW - Health status indicators
KW - Medical care
KW - Risk perception
KW - Health surveys
KW - Preventive health services
KW - United States
KW - Reagan, Ronald, 1911-2004
N1 - Accession Number: 4949136; Green, Lawrence W. 1; Wilson, Ronald W. 2; Bauer, Katherine G. 1; Affiliations: 1: Office of Health Information, Health Promotion, Physical Fitness and Sports Medicine, US Department of Health and Human Services, Washington, DC; 2: National Center for Health Statistics, Office of the Assistant Secretary for Health, US Department of Health and Human Services, Washington, DC; Issue Info: Jan1983, Vol. 73 Issue 1, p18; Subject Term: Medical policy; Subject Term: Presidents; Subject Term: Government agencies; Subject Term: Health promotion; Subject Term: Preventive medicine; Subject Term: Health status indicators; Subject Term: Medical care; Subject Term: Risk perception; Subject Term: Health surveys; Subject Term: Preventive health services; Subject: United States; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: Reagan, Ronald, 1911-2004; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harkiss, G. D.
AU - Brown, D. L.
AU - Smith, D. J.
AU - Nagington, J.
T1 - Antibody moieties within circulating immune complexes in heart transplant recipients.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/01//
VL - 51
IS - 1
M3 - Article
SP - 21
EP - 28
SN - 00099104
AB - Circulating immune complexes were isolated from the sera of cardiac allograft recipients by bovine conglutinin/anti-conglutinin co-precipitation, or by gel filtration and protein A-Sepharose affinity chromatography. The antibody moieties within these isolated immune complexes were tested for specificity against heterologous anti-thymocyte globulins by solid phase radioimmunoassay, and bacterial and viral antigens by indirect immunofluorescence. The results showed that in addition to possessing specific antiequine anti-thymocyte globulin antibodies, immune complexes also contained crossreacting antibodies to rabbit anti-thymocyte globulin and vice versa, despite the patients only having received antibody of one species. Similarly, antibodies directed against bacteria or viruses (cytomegalovirus. Herpes simplex virus, Epstein-Barr virus) were found within immune complexes obtained during overt infection, but also where infection was not detected. These results demonstrate the heterogeneous nature of immune complexes in heart transplant sera, and suggest that various stimuli, including ATG therapy, infection and possibly polyclonal B cell activation, may be involved in their generation in cardiac transplantation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - HOMOGRAFTS
KW - TRANSPLANTATION of organs, tissues, etc.
KW - BONE-grafting
KW - ANTIGENS
KW - SERUM
N1 - Accession Number: 16026862; Harkiss, G. D. 1; Brown, D. L. 1; Smith, D. J. 2; Nagington, J. 2; Source Information: Jan1983, Vol. 51 Issue 1, p21; Subject: IMMUNOGLOBULINS; Subject: HOMOGRAFTS; Subject: TRANSPLANTATION of organs, tissues, etc.; Subject: BONE-grafting; Subject: ANTIGENS; Subject: SERUM; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
T1 - Requirements for Implantation of Investigational Devices By The Food and Drug Administration.
AU - Rahmoeller, Gienn A.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1983/01//
VL - 6
IS - 1P1
SP - 151
EP - 152
SN - 01478389
N1 - Accession Number: 17118832; Author: Rahmoeller, Gienn A.: 1 ; Author Affiliation: 1 Director, Division of Cardiovascular Devices, Bureau of Medical Devices, Food and Drug Administration, Silver Springs, Maryland; No. of Pages: 2; Language: English; Publication Type: Article; Update Code: 20050526
N2 - Offers a look at the U.S. Food and Drug Administration's regulation on cardiac pacemaker implantation. Key function of the agency; Purpose of an investigation al device exemption; Factors to consider when pursuing a clinical study for investigation al devices; Overview of the procedure followed by the agency in the approval of the devices.
KW - *CARDIAC pacemakers
KW - *IMPLANTED cardiovascular instruments
KW - *ARTIFICIAL implants
KW - GOVERNMENT policy
KW - BIOMEDICAL materials -- Government policy
KW - UNITED States. Food & Drug Administration
KW - UNITED States
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=17118832&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 1983-27241-001
AN - 1983-27241-001
AU - Henton, Wendon W.
AU - Sykes, Stephen M.
T1 - Within-trial psychophysics with intertrial titration.
JF - Behaviour Analysis Letters
JO - Behaviour Analysis Letters
Y1 - 1983/01//
VL - 3
IS - 1
SP - 43
EP - 50
CY - Netherlands
PB - Elsevier Science Publishers, B.V.
SN - 0166-4794
N1 - Accession Number: 1983-27241-001. Partial author list: First Author & Affiliation: Henton, Wendon W.; US Dept of Health & Human Services Public Health Service, Food & Drug Administration, Rockville, MD. Release Date: 19831001. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Operant Conditioning; Psychophysical Measurement; Stimulus Control; Stimulus Intensity; Threshold Determination. Classification: Learning & Motivation (2420). Population: Human (10). Page Count: 8. Issue Publication Date: Jan, 1983.
AB - Studied 6 male Sprague-Dawley rats trained on a mixed signaled reinforcement procedure using a gradually increasing rather than fixed intensity white light within each signal trial. The study attempted to modify within-trial threshold techniques to increase the intensity range scanned for threshold and to increase the number of threshold determinations per session. Threshold was defined by the intensity controlling the local changeover from ongoing responses to signal key responses. The intensity scanned on each trial was approximately 1.0 log unit, with the initial intensity at stimulus onset titrated across trials. Psychophysical thresholds at 10–22 W/cm–2 replicate previous thresholds for the dark-adapted rat. The stimulus control of molecular response sequences is consistent with response pattern analyses of basic and applied conditioning schedules. (18 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intertrial titration & within-trial modification of threshold & psychophysical application of pattern analysis to study of stimulus control
KW - rats
KW - 1983
KW - Operant Conditioning
KW - Psychophysical Measurement
KW - Stimulus Control
KW - Stimulus Intensity
KW - Threshold Determination
KW - 1983
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1983-27241-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-42260-012
AN - 2013-42260-012
AU - Meketon, Melvin Jerry
T1 - Indian mental health: An orientation.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1983/01//
VL - 53
IS - 1
SP - 110
EP - 115
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Meketon, Melvin Jerry, Office of Mental Health Programs, Indian Health Service, 2401 12th St. N.W., Albuquerque, NM, US, 87102
N1 - Accession Number: 2013-42260-012. PMID: 6829716 Partial author list: First Author & Affiliation: Meketon, Melvin Jerry; Office of Mental Health Programs, Indian Health Service, Albuquerque, NM, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20131223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Meeting of the American Psychological Association, Aug, 1981, Los Angeles, CA, US. Conference Note: Based in part on a symposium at the aforementioned conference. Major Descriptor: Health Service Needs; Mental Health Services; Health Care Policy. Minor Descriptor: Population; Rural Environments. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 6. Issue Publication Date: Jan, 1983. Copyright Statement: American Orthopsychiatric Association, Inc. 1983.
AB - This paper provides a brief overview of Indian mental health needs, problems, and services among predominantly rural populations, and focuses on issues that arise when traditional Indian healing is made a part of a national health service system. Problems in developing a policy capable of integrating traditional healing with modern mental health techniques are considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Indian mental health
KW - mental health needs
KW - mental health services
KW - rural populations
KW - health care policy
KW - 1983
KW - Health Service Needs
KW - Mental Health Services
KW - Health Care Policy
KW - Population
KW - Rural Environments
KW - 1983
DO - 10.1111/j.1939-0025.1983.tb03355.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-42260-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1983-28899-001
AN - 1983-28899-001
AU - Quick, Jonathan D
AU - Moorhead, Gregory
AU - Quick, James C.
AU - Gerloff, Edwin A.
AU - Mattox, Kenneth L.
AU - Mullins, Charles
T1 - Decision-making among emergency room residents: Preliminary observations and a decision model.
JF - Journal of Medical Education
JO - Journal of Medical Education
Y1 - 1983/02//
VL - 58
IS - 2
SP - 117
EP - 125
CY - US
PB - Lippincott Williams & Wilkins
N1 - Accession Number: 1983-28899-001. PMID: 6822982 Other Journal Title: Academic Medicine. Partial author list: First Author & Affiliation: Quick, Jonathan D; Public Health Service Indian Hosp, Talihina, OK. Release Date: 19831001. Correction Date: 20130429. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Emergency Services; Medical Residency; Medical Students. Classification: Professional Education & Training (3410). Population: Human (10). Page Count: 9. Issue Publication Date: Feb, 1983.
AB - Studied 2 hospitals using data gathered from 30 interviews with medical and surgical staffs of the emergency rooms and 100 hrs of observation in order to examine the decision-making processes of emergency room residents. It was found that collaborative decision making of the consultive and consensual types is an important activity of practicing physicians, and this type of thinking is developed during the training period. (12 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - decision-making processes in hospital emergency rooms
KW - residents
KW - 1983
KW - Decision Making
KW - Emergency Services
KW - Medical Residency
KW - Medical Students
KW - 1983
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1983-28899-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1984-20282-001
AN - 1984-20282-001
AU - Broudy, David W.
AU - May, Philip A.
T1 - Demographic and epidemiologic transition among the Navajo Indians.
JF - Biodemography and Social Biology
JO - Biodemography and Social Biology
JA - Biodemography Soc Biol
Y1 - 1983///Spr 1983
VL - 30
IS - 1
SP - 1
EP - 16
CY - US
PB - Society for the Study of Social Biology
SN - 1948-5565
SN - 1948-5573
N1 - Accession Number: 1984-20282-001. Other Journal Title: Eugenics Quarterly. Partial author list: First Author & Affiliation: Broudy, David W.; US Dept of Health & Human Services, Indian Health Service Health Planning Evaluation & Analysis Branch, Albuquerque, NM. Release Date: 19840801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Birth Rate; Mortality Rate; Social Change. Minor Descriptor: Demographic Characteristics; Epidemiology. Classification: Culture & Ethnology (2930). Population: Human (10). Page Count: 16. Issue Publication Date: Spr 1983.
AB - Analyzed mortality and natality data for Navajos compiled by the Indian Health Service. It is contended that the major implications for social and health planning with the Navajos result from the social change toward modernization. Their higher-than-average mortality rate reflects deaths from vehicle accidents, alcoholism, suicide, homicide, and cirrhosis of the liver. In addition to public awareness and emergency medical services, culturally sensitive economic development must be encouraged. Demographic and epidemiologic transitions are underway among Navajo Indians. (29 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social change & demographic & epidemiologic transition
KW - Navajo Indians
KW - 1983
KW - American Indians
KW - Birth Rate
KW - Mortality Rate
KW - Social Change
KW - Demographic Characteristics
KW - Epidemiology
KW - 1983
DO - 10.1080/19485565.1983.9988511
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1984-20282-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06529-042
AN - 2006-06529-042
AU - Stolz, Stephanie B.
T1 - Ethics From the Standpoint of a Psychologist.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1983/03//
VL - 28
IS - 3
SP - 230
EP - 231
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06529-042. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Stolz, Stephanie B.; Division of Alcoholism, Drug Abuse, and Mental Health Programs, U.S. Public Health Service, Kansas City, MO, US. Release Date: 20061120. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Deception; Experimental Ethics; Informed Consent. Minor Descriptor: Morality; Psychologists. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Reviewed Item: Keehn, J. D. (Ed). The Ethics of Psychological Research=New York: Pergamon Press, 1982. 92 pp. $18.50; 1982. Page Count: 2. Issue Publication Date: Mar, 1983.
AB - Reviews the book, The Ethics of Psychological Research edited by J. D. Keehn (1982). In this book some of the key dilemmas in the ethics of psychological research are well covered, including the use of animals, informed consent from adult human subjects, and the use of deception. But other major issues are mentioned only briefly. Very few of the eleven papers in this book on the ethics of psychological research treat the topics of ethics and morals from the point of view of what psychologists know; rather, nearly all of them present what seems right to the authors in their own value systems, or as amateur philosophers. The chief exceptions are a chapter on the issue of subjects' rights in the context of countercontrol and another on the use of survey research methodology to assess what the public finds acceptable and unacceptable in psychological research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological research
KW - ethics
KW - deception
KW - psychologists
KW - informed consent
KW - 1983
KW - Deception
KW - Experimental Ethics
KW - Informed Consent
KW - Morality
KW - Psychologists
KW - 1983
U2 - Keehn, J. D. (Ed). (1982); The Ethics of Psychological Research; New York: Pergamon Press, 1982. 92 pp. $18.50
DO - 10.1037/021882
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06529-042&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - POUNDS, JOEL G.
AU - MITTELSTAEDT, ROBERTA A.
T1 - Mobilization of Cellular Calcium-45 and Lead-210: Effect of Physiological Stimuli.
JO - Science
JF - Science
Y1 - 1983/04/15/
VL - 220
IS - 4594
M3 - Article
SP - 308
EP - 310
SN - 00368075
AB - Isolated rat hepatocytes in primary culture were used as a model system to evaluate the effects of selected hormones and culture conditions on the efflux of calcium45 and lead-210 from cells labeled with these isotopes. Alpha-adrenergic stimuli, angiotensin, vasopressin, dibutyryl adenosine 3',5'-monophosphate, and reduced phosphate concentrations in the medium increased the efflux of calcium45 and lead-210. Glucagon and insulin had no effect, but increased phosphate concentrations decreased the efflux of both isotopes. Experiments with hepatocytes cultured in a medium free of calcium and lead demonstrated that the increased efflux of calcium45 and lead-210 induced by hormones was the result of mobilization of the ions from intracellular stores. The data indicate that the physiological stimuli that mobilized calcium ions also mobilized lead ions, and that the mobilized lead would be available to interact with calcium-mediated cell functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84713068; POUNDS, JOEL G. 1,2; MITTELSTAEDT, ROBERTA A. 3; Affiliations: 1: Division of Mutagenesis Research, National Center for Toxicological Research, Jefferson, Arkansas 72079; 2: Division of Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205; 3: Division of Mutagenesis Research, National Center for Toxicological Research; Issue Info: 4/15/1983, Vol. 220 Issue 4594, p308; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=84713068&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Coffey, Rosanna M.
T1 - THE EFFECT OF TIME PRICE ON THE DEMAND FOR MEDICAL - CARE SERVICES.
JO - Journal of Human Resources
JF - Journal of Human Resources
Y1 - 1983///Summer83
VL - 18
IS - 3
M3 - Article
SP - 407
EP - 424
PB - University of Wisconsin Press
SN - 0022166X
AB - ABSTRACT This paper analyzes the effect of time price on medical-care demand and describes use of a reservation-wage question from a household survey to develop a measure of time price for obtaining medical care. A comprehensive three-equation model of the demand for female medical-care services examines choice of provider, entry demand, and the demand for physician visits. Results show that provider choice is based primarily on economic factors and that an expected high time price discourages women from choosing a public provider and from seeking gynecological, maternal-health, or family-planning services during the year, yet does not influence the number of visits made once care is used. The estimated model shows that medical-care demand equations should control for the type of provider chosen and the opportunity cost of time for alternative activities when testing for a negative time price effect of obtaining medical care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Human Resources is the property of University of Wisconsin Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - DEMAND (Economic theory)
KW - WAGES
KW - PRICING
KW - PRICES
KW - HEALTH insurance
KW - MEDICAL care costs
KW - HOUSEHOLDS
KW - HOUSEHOLD surveys
KW - WOMEN -- Health
KW - WOMEN'S health services
N1 - Accession Number: 5078697; Coffey, Rosanna M. 1; Affiliations: 1: National Center for Health Services Research, Public Health Service, U.S. Department of Health and Human Services; Issue Info: Summer83, Vol. 18 Issue 3, p407; Thesaurus Term: MEDICAL care; Thesaurus Term: DEMAND (Economic theory); Thesaurus Term: WAGES; Thesaurus Term: PRICING; Thesaurus Term: PRICES; Thesaurus Term: HEALTH insurance; Subject Term: MEDICAL care costs; Subject Term: HOUSEHOLDS; Subject Term: HOUSEHOLD surveys; Subject Term: WOMEN -- Health; Subject Term: WOMEN'S health services; NAICS/Industry Codes: 814110 Private Households; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 18p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=5078697&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Zervos, Constantlne
AU - Frlnger, Joanna
T1 - Preface.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - v
EP - vi
SN - 07313810
N1 - Accession Number: 79032209; Zervos, Constantlne 1; Frlnger, Joanna 2; Affiliations: 1: Food and Drug Administration, Washington, DC; 2: Technical Resources, Inc., Bethesda, Maryland; Issue Info: 1983, Vol. 21 Issue 1/2, pv; Number of Pages: 2p; Document Type: Article
L3 - 10.3109/15563658308990405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032209&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wagstaff, David J.
T1 - Food Intake Assessment in the United States.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 151
EP - 168
SN - 07313810
N1 - Accession Number: 79032211; Wagstaff, David J. 1; Affiliations: 1: Epidemiology and Clinical Toxicology Unit Bureau of Foods Food and Drug Administration, Washington, DC, 20204; Issue Info: 1983, Vol. 21 Issue 1/2, p151; Number of Pages: 18p; Document Type: Article
L3 - 10.3109/15563658308990414
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032211&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Biddle, Garfield N.
T1 - Exposure Assessment as a Tool in Regulatory Decisions to Ensure Food Safety.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 169
EP - 180
SN - 07313810
N1 - Accession Number: 79032219; Biddle, Garfield N. 1; Affiliations: 1: Contaminants and Natural Toxicants Evaluation Branch, Division of Toxicology, Bureau of Foods Food and Drug Administration, Washington, DC, 20204; Issue Info: 1983, Vol. 21 Issue 1/2, p169; Number of Pages: 12p; Document Type: Article
L3 - 10.3109/15563658308990415
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032219&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yetley, Elizabeth A.
AU - Hanson, Eric A.
T1 - Data Sources and Methods for Estimating Consumption of Food Components.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 181
EP - 200
SN - 07313810
N1 - Accession Number: 79032220; Yetley, Elizabeth A. 1; Hanson, Eric A. 1; Affiliations: 1: Division of Nutrition, Bureau of Foods Food and Drug Administration, Washington, DC, 20204; Issue Info: 1983, Vol. 21 Issue 1/2, p181; Number of Pages: 20p; Document Type: Article
L3 - 10.3109/15563658308990416
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032220&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frazier, Todd
T1 - Niosh Occupational Health and Hazard Surveillance Systems.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 201
EP - 209
SN - 07313810
N1 - Accession Number: 79032204; Frazier, Todd 1; Affiliations: 1: Centers for Disease Control National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226; Issue Info: 1983, Vol. 21 Issue 1/2, p201; Number of Pages: 9p; Document Type: Article
L3 - 10.3109/15563658308990417
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032204&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jones, Judith K.
AU - Kennedy, Dianne L.
T1 - Data Sources and Methods for Ascertaining Human Exposure to Drugs.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 237
EP - 251
SN - 07313810
N1 - Accession Number: 79032203; Jones, Judith K. 1; Kennedy, Dianne L. 1; Affiliations: 1: Division of Drug Experience, National Center for Drugs and Biologics Food and Drug Administration, Rockvilie, Maryland, 20857; Issue Info: 1983, Vol. 21 Issue 1/2, p237; Number of Pages: 15p; Document Type: Article
L3 - 10.3109/15563658308990419
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032203&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - VanDecarr, Stephen W.
T1 - Use of Existing Computerized Data Bases in Drug Exposure Assessment.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - 253
EP - 263
SN - 07313810
N1 - Accession Number: 79032212; VanDecarr, Stephen W. 1; Affiliations: 1: National Center for Drugs and Biologies Food and Drug Administration, Washington, DC, 20204; Issue Info: 1983, Vol. 21 Issue 1/2, p253; Number of Pages: 11p; Document Type: Article
L3 - 10.3109/15563658308990420
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032212&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zervos, Constantine
T1 - Introduction.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1983/06//
VL - 21
IS - 1/2
M3 - Article
SP - vii
EP - xvii
SN - 07313810
N1 - Accession Number: 79032202; Zervos, Constantine 1; Affiliations: 1: National Center for Drugs and Biologics, Pharmaceutical Research and Testing Food and Drug Administration, Washington, DC, 20204; Issue Info: 1983, Vol. 21 Issue 1/2, pvii; Number of Pages: 11p; Document Type: Article
L3 - 10.3109/15563658308990406
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=79032202&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kuespert, Edward F.
T1 - Limitations on Moving Ahead, While Cutting Back.
JO - Public Budgeting & Finance
JF - Public Budgeting & Finance
Y1 - 1983///Summer83
VL - 3
IS - 2
M3 - Article
SP - 79
EP - 82
PB - Wiley-Blackwell
SN - 02751100
AB - The federal government is undergoing major reductions in programs. While some programs are being eliminated, managers of others are being asked to reduce costs but to move ahead in providing improved services to the public. The Food and Drug Administration (FDA) provides consumer protection to the public by ensuring that regulated products are safe, wholesome, and effective. This is a discussion of limitations to be considered and the need for managerial flexibility within programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Budgeting & Finance is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FEDERAL regulation
KW - FEDERAL government
KW - FEDERAL legislation
KW - GOVERNMENT programs
KW - COST control
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 4668096; Kuespert, Edward F. 1; Affiliations: 1: Chief, Planning and Resource Management Branch, National Center for Drugs and Biologics, Food and Drug Administration.; Issue Info: Summer83, Vol. 3 Issue 2, p79; Thesaurus Term: FEDERAL regulation; Thesaurus Term: FEDERAL government; Thesaurus Term: FEDERAL legislation; Thesaurus Term: GOVERNMENT programs; Thesaurus Term: COST control; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=4668096&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1988-14823-001
AN - 1988-14823-001
AU - Koop, C. Everett
T1 - Perspectives on future health care.
JF - Health Psychology
JO - Health Psychology
JA - Health Psychol
Y1 - 1983///Sum 1983
VL - 2
IS - 3
SP - 303
EP - 312
CY - US
PB - Lawrence Erlbaum Associates
SN - 0278-6133
SN - 1930-7810
N1 - Accession Number: 1988-14823-001. Partial author list: First Author & Affiliation: Koop, C. Everett; US Dept of Health & Human Services, Public Health Service, Washington, DC, US. Other Publishers: American Psychological Association. Release Date: 19880501. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: American Psychological Association, Division of Health Psychology (1982, Washington, DC). Major Descriptor: Health Behavior; Health Care Delivery; Health Care Services; Public Health Services. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: Sum 1983.
AB - Discusses the achievement of health goals for the future through changes in behavior. Goals include immunization, lowering the infant mortality rate, controlling blood pressure, and lowering the number of cigarette smokers. The role of health care providers in this effort is discussed, and reports from the Public Health Service and the American Psychological Association are briefly described. Society's options for promoting positive health behaviors without being coercive and the responsibility of researchers to practice with integrity are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perspective on future health care goals & role of health care providers
KW - conference presentation
KW - 1983
KW - Health Behavior
KW - Health Care Delivery
KW - Health Care Services
KW - Public Health Services
KW - 1983
DO - 10.1037/0278-6133.2.3.303
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1984-06119-001
AN - 1984-06119-001
AU - Henton, Wendon W.
AU - Sykes, Stephen M.
T1 - Changes in absolute threshold with light-induced retinal damage.
JF - Physiology & Behavior
JO - Physiology & Behavior
JA - Physiol Behav
Y1 - 1983/08//
VL - 31
IS - 2
SP - 179
EP - 185
CY - Netherlands
PB - Elsevier Science
SN - 0031-9384
N1 - Accession Number: 1984-06119-001. PMID: 6634984 Partial author list: First Author & Affiliation: Henton, Wendon W.; US Dept of Health & Human Services Food & Drug Administration, Public Health Service, Rockville, MD. Release Date: 19840301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Illumination; Retina; Visual Thresholds. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 7. Issue Publication Date: Aug, 1983.
AB - Six male Sprague-Dawley albino rats were trained on a mixed signalled reinforcement procedure designed to yield repeated absolute visual thresholds within each session. After threshold stability, Ss were exposed 12 hrs/night to 1,000 lux of light from a cool-white fluorescent source. Log threshold rose as an approximate linear function of exposure time to a maximum of 2.0 log units above baseline after 36 cumulative hours of exposure. Light and electron microscopic analysis of irradiated retinas revealed vesiculated photoreceptor outer segments, with varying degrees of vacuolation of the inner segments and pyknosis of photoreceptor nuclei depending on exposure time. The various combinations of retinal pathology suggested that damage to photoreceptor outer segments and inner segments interacted to jointly affect psychophysical thresholds in light-induced retinal damage. (25 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - light-induced retinal damage
KW - absolute visual thresholds
KW - male rats
KW - 1983
KW - Illumination
KW - Retina
KW - Visual Thresholds
KW - Rats
KW - 1983
DO - 10.1016/0031-9384(83)90116-6
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
T1 - Evidence that AV Nodal Re-Entrant Tachycardia Does Not Require Participation of the Entire AV Node.
AU - Hariman, Robert J.
AU - Chia-Maou Chen
AU - Caracta, Antonio R.
AU - Damato, Anthony N.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1983/09/15/
VL - 6
IS - 5P2
SP - 1252
EP - 1257
SN - 01478389
N1 - Accession Number: 17224866; Author: Hariman, Robert J.: 1 Author: Chia-Maou Chen: 1 Author: Caracta, Antonio R.: 1 Author: Damato, Anthony N.: 1 ; Author Affiliation: 1 Department of Cardiology, U.S. Public Health Service Hospital, Staten Island, New York; No. of Pages: 6; Language: English; Publication Type: Article; Update Code: 20050608
N2 - Electrophysiologic studies in a case of AV nodal re-entrant tachycardia showed that a programmed atrial premature depolarization induced during the tachycardia did not change the tachycardia cycle but caused a delay in the following atrial echo. Analysis of such a phenomenon suggests that the atrial premature depolarization was conducted to the upper part of the AV node but not to the site of the re-entry. Therefore. AV nodal re-entry can persist without the participation of the upper part of the AV node. This case illustrates that the upper common pathway connecting the dual A V nodal pathways cranially is most likely located within the AV node and consists of AV nodal tissue. ABSTRACT FROM AUTHOR
KW - *ATRIOVENTRICULAR node
KW - *ELECTROPHYSIOLOGY
KW - *TACHYCARDIA
KW - *AFFERENT pathways
KW - *HEART conduction system
KW - AV node
KW - dual pathway
KW - lower common pathway
KW - re-entry
KW - upper common pathway
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Stenberg, Carl W.
AU - Barkdoll, Gerald L.
T1 - Concentering: A Useful Preplanning Activity.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1983/11//Nov/Dec83
VL - 43
IS - 6
M3 - Article
SP - 556
PB - Wiley-Blackwell
SN - 00333352
AB - The article focuses on concentering, a useful preplanning activity. Concentering is an important preplanning activity. It identifies the disruptive "alligators" and coalesces the planning participants into a team ready and able to grapple with the rigors of planning. Concentering is particularly important during times of stress; for example, when resources are scarce, the planning process pits program against program, organization against organization, and planning participant against planning participant. Concentering is designed to bring the planning participants to a shared starting point. Concentering activities must be capable of recognizing, organizing, and dealing with factors as diverse as organizational values, goals, strengths and weaknesses, environment, self image, culture, and role. Successful concentering may reduce the costs of the planning process by avoiding the expense and waste of noncommunication and suboptimum decisions, but concentering has its own costs. Bringing the planning participants to a shared starting point is a challenging and difficult undertaking.
KW - PLANNING
KW - ORGANIZATION
KW - ORGANIZATIONAL behavior
KW - JOB stress
KW - COST control
KW - COST effectiveness
KW - ATTENTION
KW - VALUES (Ethics)
N1 - Accession Number: 4595882; Stenberg, Carl W.; Barkdoll, Gerald L. 1; Affiliations: 1: U.S. Food and Drug Administration.; Issue Info: Nov/Dec83, Vol. 43 Issue 6, p556; Thesaurus Term: PLANNING; Thesaurus Term: ORGANIZATION; Thesaurus Term: ORGANIZATIONAL behavior; Thesaurus Term: JOB stress; Thesaurus Term: COST control; Thesaurus Term: COST effectiveness; Subject Term: ATTENTION; Subject Term: VALUES (Ethics); Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Magrath, Ian
AU - Erikson, Jan
AU - Whang-Peng, Jacqueline
AU - Sieverts, Hauke
AU - Armstrong, Gary
AU - Benjamin, David
AU - Triche, Timothy
AU - Alabaster, Oliver
AU - Croce, Carlo M.
T1 - Synthesis of Kappa Light Chains by Cell Lines Containing an 8;22 Chromosomal Translocation Derived from a Male Homosexual with Burkitt's Lymphoma.
JO - Science
JF - Science
Y1 - 1983/12/09/
VL - 222
IS - 4628
M3 - Article
SP - 1094
EP - 1098
SN - 00368075
AB - Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence ofimmunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm ofchromosome 8 and a chromosome bearing an immunoglobulin gene, alteration ofcellular myc expression may occur regardless of the immunoglobulin gene that is expressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 84671938; Magrath, Ian 1; Erikson, Jan 2; Whang-Peng, Jacqueline 3; Sieverts, Hauke 1; Armstrong, Gary 4; Benjamin, David 1; Triche, Timothy 5; Alabaster, Oliver 6; Croce, Carlo M. 2; Affiliations: 1: Pediatric Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205; 2: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3: Medicine Branch, Division of Cancer Treatment, National Cancer Institute; 4: Division of Virology, Office of Biologics, National Center of Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland 20205; 5: Laboratory of Pathology, National Cancer Institute; 6: Division of Hematology/Oncology, George Washington University, Washington, D.C. 20037; Issue Info: 12/ 9/1983, Vol. 222 Issue 4628, p1094; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Oliver, Richard L.
AU - Walbridge, R. Hoyt
AU - Rheinstein, Peter H.
T1 - A STUDY OF PHYSICIANS' PERCEPTION OF ADVERTISING JUDGED DECEPTIVE BY THE FDA.
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 1984/01//
VL - 11
IS - 1
M3 - Article
SP - 224
EP - 228
PB - Association for Consumer Research
SN - 00989258
AB - A fictitious medical journal was used as a medium to determine if a prescription drug advertisement judged deceptive by the FDA achieved that alleged effect. One hundred fifty physicians were exposed to the misleading ad and an FDA approved non-misleading version in a controlled field experiment. Interview results showed that physicians were inclined to perceive more efficacious drug claims in the misleading treatment and that this effect increased for the more inaccurate claims. Implications for the advertising and medical communities and for FDA's regulatory activities were discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIRECT-to-consumer prescription drug advertising
KW - ADVERTISING
KW - PHYSICIANS
KW - FALSE advertising
KW - CONSUMER protection
KW - DRUGS
KW - MEDICAL literature
KW - PERIODICALS
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 6434135; Oliver, Richard L. 1; Walbridge, R. Hoyt 2; Rheinstein, Peter H. 3; Affiliations: 1: Washington University; 2: Institute for Survey Research, Temple University; 3: Office of Drugs, Food and Drug Administration; Issue Info: 1984, Vol. 11 Issue 1, p224; Thesaurus Term: DIRECT-to-consumer prescription drug advertising; Thesaurus Term: ADVERTISING; Thesaurus Term: PHYSICIANS; Thesaurus Term: FALSE advertising; Thesaurus Term: CONSUMER protection; Subject Term: DRUGS; Subject Term: MEDICAL literature; Subject Term: PERIODICALS ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541850 Outdoor Advertising; NAICS/Industry Codes: 541890 Other Services Related to Advertising; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1984-29680-001
AN - 1984-29680-001
AU - Burns, Thomas R.
T1 - An application of Indian Health Service standards for alcoholism programs.
JF - White Cloud Journal of American Indian Mental Health
JO - White Cloud Journal of American Indian Mental Health
Y1 - 1984///
VL - 3
IS - 2
SP - 26
EP - 34
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0886-5027
N1 - Accession Number: 1984-29680-001. Other Journal Title: American Indian and Alaska Native Mental Health Research; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Burns, Thomas R.; Phoenix Area Office of Indian Health Service, Alcoholism Programs, AZ. Release Date: 19841101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Rehabilitation; American Indians; Mental Health Program Evaluation. Minor Descriptor: Alcoholism. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Page Count: 9. Issue Publication Date: 1984.
AB - Evaluated 10 alcoholism programs funded by the Indian Health Service (IHS) with the 1st manual issuance of IHS standards for alcoholism programs. The instrument consisted of 106 standards for which a range of points could be ascribed, and each program was evaluated on the basis of administrative preparedness, case management system, and standards for each service element. Results show that the standards require revision into discrete segments that focus on specific areas. (24 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - application of Indian Health Service standards for alcoholism programs
KW - 1984
KW - Alcohol Rehabilitation
KW - American Indians
KW - Mental Health Program Evaluation
KW - Alcoholism
KW - 1984
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1985-17620-001
AN - 1985-17620-001
AU - Jason, Janine
T1 - Centers for Disease Control and the epidemiology of violence.
JF - Child Abuse & Neglect
JO - Child Abuse & Neglect
JA - Child Abuse Negl
Y1 - 1984///
VL - 8
IS - 3
SP - 279
EP - 283
CY - Netherlands
PB - Elsevier Science
SN - 0145-2134
N1 - Accession Number: 1985-17620-001. PMID: 6089977 Partial author list: First Author & Affiliation: Jason, Janine; US Public Health Service, Ctrs for Disease Control Ctr for Health Promotion & Education, Atlanta, GA. Release Date: 19850701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Abuse; Epidemiology; Homicide; Suicide; Violence. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Methodology: Empirical Study. Page Count: 5. Issue Publication Date: 1984.
AB - Discusses violence as a major cause of morbidity and mortality in the US and the application of epidemiologic techniques employed by the Center for Health Promotion and Education (the Centers for Disease Control; CDC) to study the problems of child abuse, child homicide, homicide, and suicide. CDC's involvement in these areas has evolved in association with significant shifts in emphasis in public health policy and planning, from areas of acute and infectious diseases to areas of chronic diseases and premature mortality. The problems of reporting biases and definitional variability have recently been addressed in regard to child abuse and child homicide in the US. The CDC is also currently epidemiologically investigating the underrecording of child homicide in this country. Future work will include delineation and evaluation of programs to prevent violence toward children and examination of the relationship between intrafamilial violence and extrafamilial, non-crime-related violence. (French abstract) (13 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - role of violence & application of epidemiologic techniques used by Centers for Disease Control to study problems of child abuse & homicide & suicide
KW - 1984
KW - Child Abuse
KW - Epidemiology
KW - Homicide
KW - Suicide
KW - Violence
KW - 1984
DO - 10.1016/0145-2134(84)90067-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1985-17620-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1985-25021-001
AN - 1985-25021-001
AU - Shaw, Jon A.
T1 - Goethe's Elective Affinities: Themes on loss and restoration.
JF - Psychoanalytic Inquiry
JO - Psychoanalytic Inquiry
JA - Psychoanal Inq
Y1 - 1984///
VL - 4
IS - 4
SP - 627
EP - 641
CY - US
PB - Analytic Press
SN - 0735-1690
N1 - Accession Number: 1985-25021-001. Partial author list: First Author & Affiliation: Shaw, Jon A.; US Office of the Surgeon General, Washington, DC. Other Publishers: Taylor & Francis. Release Date: 19851001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Artists; Grief; Literature; Object Relations; Psychoanalytic Interpretation. Minor Descriptor: Marital Relations; Psychosexual Development. Classification: Literature & Fine Arts (2610). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 15. Issue Publication Date: 1984.
AB - Contends that although the novel, Elective Affinities, may be little-known or valued as a literary contribution of Goethe, it was of great personal significance to the author. The manifest theme of the novel is concerned with marital fidelity and infidelity; the latent content is concerned with Goethe's continuing conflict over his incestual wishes and his defenses against them. It is suggested that Goethe's creativity was partially linked to his failure to sever the idealized loving attachment to the image of the primary object, his mother, and later, his sister. (26 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - themes on loss & restoration & object relations in J. Goethe's 'Elective Affinities'
KW - 1984
KW - Artists
KW - Grief
KW - Literature
KW - Object Relations
KW - Psychoanalytic Interpretation
KW - Marital Relations
KW - Psychosexual Development
KW - 1984
DO - 10.1080/07351698409533567
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1985-25021-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Warshawsky, David
AU - Bingham, Eula
AU - Niemeier, Richard W.
T1 - The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 191
EP - 209
SN - 00984108
AB - An isolated perfused New Zealand rabbit lung preparation was used to investigate the effects of a cocarcinogen, ferric oxide (Fe 2 O 3 ), on the metabolism of benzo[a]pyrene (BaP), a ubiquitous potent carcinogen that has been associated with the increased incidence of human bronchiogenic carcinoma in occupational and urban settings. [ 14 C]‐BaP was administered intratracheally to an isolated perfused lung (IPL) preparation with and without Fe 2 O 3 after intraperitoneal pretreatment of the whole animal with BaP or intratracheal pretreatment of the whole animal with Fe 2 O 3 and/or BaP. BaP and its metabolites were isolated from serial blood samples up to 180 min after administration of [ 14 C]BaP to the IPL. BaP and its metabolites were also isolated from lung tissue, washout fluid, macrophage, and trachea bronchi at the end of the perfusion at 180 min. Patterns of BaP metabolites were determined by chromatographic techniques and liquid scintillation counting. Fe 2 O 3 pretreatment to the whole animal or administration of Fe 2 O 3 to the IPL altered BaP metabolism by the perfused lung. Fe 2 O 3 pretreatment to the whole animal resulted in an increase in the total rate of appearance of metabolites of BaP in the blood (ng/g lung·h), while Fe 2 O 3 administration to the IPL resulted in a decrease in the total rate of appearance of BaP metabolites in the blood and inhibited the effect of pretreatment. Administration of Fe 2 O 3 with BaP to the IPL with or without Fe 2 O 3 pretreatment to the whole animal, or BaP administration to the IPL preceded by Fe 2 O 3 pretreatment to the whole animal, enhanced dihydrodiol formation and depressed formation of water‐soluble metabolites. Since dihydrodiol formation is considered to be the active pathway of BaP metabolism, these data suggest that pulmonary exposure to a known cocarcinogen, Fe 2 O 3 , in the presence of BaP results in increased production of dihydrodiols of BaP, which may be further metabolized to the ultimate carcinogenic form(s) of BaP. Therefore, Fe 2 O 3 can enhance the metabolic activation of BaP by the lung, as well as act as a carrier for penetration and retention of BaP in the lung. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457034; Warshawsky, David 1; Bingham, Eula 2; Niemeier, Richard W. 3; Source Information: Jan1984, Vol. 14 Issue 2/3, p191; Number of Pages: 19p; Document Type: Article
L3 - 10.1080/15287398409530573
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DB - hch
ER -
TY - JOUR
AU - Chou, Ming W.
AU - Fu, Peter P.
T1 - Stereoselective metabolism of 8‐and 9‐fluorobenzo[a]pyrene by rat liver microsomes: Absolute configurations of trans ‐dihydrodiol metabolites.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 211
EP - 223
SN - 00984108
AB - Rat liver microsomal metabolism of 8‐fluorobenzo[a]pyrene (8‐fluoro‐BaP) generated 3‐hydroxy‐8‐fluora‐BaP, 8‐fluoro‐BaP trans‐4,5‐dihydrodiol, and 8‐fluoro‐BaP, 3,6‐quinone as major products. A minor metabolite of 8‐fluoro‐BaP was tentatively assigned as 8‐fluoro‐BaP 9,10‐dihydrodiol. Metabolism of 9‐fluorobenzo[a] pyrene (9‐fluoro‐BaP) gave 3‐hydroxy‐9‐fluoro‐BaP, 9‐fluoro‐BaP trans‐4,5‐dihydrodiol, 9‐fluoro‐BaP trans‐7,8‐dihydrodiol, and 9‐fluoro‐BaP 3,6‐quinone. All three dihydrodiol metabolites were optically active. Comparison of the circular dichroism spectra of BaP 4R,5R‐dihydrodiol, 6‐bromo‐BaP 7R,8R‐dihydrodiol, and 6‐fluoro‐BaP 7R,8R‐dihydrodiol with those of the respective dihydrodiol metabolites allowed assignments of an R,R absolute configuration to the major enantiomers of the three dihydrodiol metabolites. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457035; Chou, Ming W. 1; Fu, Peter P. 1; Source Information: Jan1984, Vol. 14 Issue 2/3, p211; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/15287398409530574
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ER -
TY - JOUR
AU - Russo, J. M.
AU - Anger, W. K.
AU - Setzer, J. V.
AU - Brightwell, W. S.
T1 - Neurobehavioral assessment of chronic low‐level methyl bromide exposure in the rabbit.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 247
EP - 255
SN - 00984108
AB - The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neuro‐behavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long‐term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6–8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457038; Russo, J. M. 1; Anger, W. K. 2; Setzer, J. V. 2; Brightwell, W. S. 2; Source Information: Jan1984, Vol. 14 Issue 2/3, p247; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15287398409530577
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Wirtz, George H.
AU - Olenchock, Stephen A.
T1 - Elemental analysis of airborne grain dusts.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1984/01/03/
VL - 19
IS - 3
M3 - Article
SP - 379
EP - 391
SN - 03601234
AB - The elemental composition of a group of airborne and settled grain dusts is reported. This survey was undertaken as part of a study to systematically describe the chemistry and morphology of these representative dusts. Our data show that airborne or set‐tled grain dusts differ from each other with respect to elemental composition. Such fundamental differences may be related to previously observed differences in the biological activities of the dusts. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75387082; Wirtz, George H. 1; Olenchock, Stephen A. 2; Affiliations: 1: Departments of Biochemistry and Microbiology, West Virginia University Medical Center, Morgantown, WV, 26506; 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, 26506; Issue Info: Jan1984, Vol. 19 Issue 3, p379; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/03601238409372437
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75387082&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vallyathan, V.
AU - Robinson, V.
AU - Reasor, M.
AU - Stettler, L.
AU - Bernstein, R.
T1 - Comparative in vitro cytotoxicity of volcanic ashes from Mount St. Helens, El Chichon, and Galunggung.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 641
EP - 654
SN - 00984108
AB - Dry sedimented volcanic ash samples from each of three widely separated volcanoes of the “Circum Pacific” region have been subjected to mineralogic analysis and in vitro tests for cytotoxicity. The ash samples from the three different volcanoes varied in particle size, surface area, and concentration of silica. Total crystalline silica in the respirable fraction of ashes was 1.5% (Mount St. Helens, Moses Lake); 1.36% (Galunggung, Bandung‐1); 1.95% (Gallunggung, Bandung‐2); and 1.72% (El Chichon, Tuxtia). Hemolysis as an index of cytotoxicity was measured by in vitro tests on sheep blood erythrocytes and indicated wide differences in hemolytic activity among ash samples. Alveolar macrophage cytosolic (lactate dehydrogenase) and lysosomal (β‐glucuronidase and β‐N‐acetyl glucosaminidase) enzymes were measured as an index of cellular integrity following dust exposure. Hemolysis and release of enzymes from alveolar macrophages were greater with volcanic ash from Galunggung (Bandung‐1) and El Chichon (Tuxtia) than the other ashes. Although crystalline silica induced an effect similar to volcanic ash from Galunggung (Bandung‐1) on the release of enzymes from alveolar macrophages, the hemolytic potency of silica was much greater. Light and electron microscopic observations of dust‐exposed alveolar macrophages indicated that the ash particles were readily phagocytized. These results indicate that volcanic ash is moderately cytotoxic and that exposure may lead to overt reactions and the exacerbation of preexisitng chronic inflammatory processes. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457096; Vallyathan, V. 1; Robinson, V. 2; Reasor, M. 3; Stettler, L. 4; Bernstein, R. 5; Source Information: Jan1984, Vol. 14 Issue 5/6, p641; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/15287398409530614
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=75457096&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rabovsky, Jean
AU - Petersen, Martin R.
AU - Lewis, Trent R.
AU - Marion, Karl J.
AU - Groseclose, Robert D.
T1 - Chronic inhalation of diesel exhaust and coal dust: Effect of age and exposure on selected enzyme activities associated with microsomal cytochrome p‐450 in rat lung and liver.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 655
EP - 666
SN - 00984108
AB - Male Fisher‐344 rats were exposed by inhaltion to low levels of diesel exhaust and coal dust, alone or in combination, or to filtered air, 7 h/d, 5 d/wk for 24 mo. Cyto‐chrome P‐450‐associated benzo[a]pyrene hydroxylase and 7‐ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 mo. Age‐related changes in enzyme activities were observed, but they were not altered by the exposures. When the data were adjusted for age, only one difference was observed. Lung benzo[a]pyrene hydroxylase activity in rats exposed to diesel exhaust and coal dust in combination was lower than that in animals exposed to coal dust alone (2.8 versus 4.4 pmol/min·mg protein). Neither value, however, differed significantly from the filtered‐air controls, and no differences were observed in the other lung and liver activities. The data suggest exposure of the rats to diesel exhaust and/or coal dust had little or no effect on the selected lung and liver cytochrome P‐450 activities under the conditions of the experiment. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457097; Rabovsky, Jean 1; Petersen, Martin R. 2; Lewis, Trent R. 2; Marion, Karl J. 2; Groseclose, Robert D. 2; Source Information: Jan1984, Vol. 14 Issue 5/6, p655; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287398409530615
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Groce, Donald F.
AU - Kimbrough, Renate D.
T1 - Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 695
EP - 706
SN - 00984108
AB - Firemaster FF‐1, a polybrominated biphenyl (PBB) mixture, was dissolved in corn oil and given as a dose of 200 mg/kg body weight to Sherman rats on d 7 and 14 of pregnancy. Control rats received equivalent doses of corn oil alone. Selected pups and all dams were killed 1 mo after pups were weaned. A total of 50 male and 50 female offspring per group were followed until they were 2 yr old. The livers of offspring killed at the ages of 2 mo and 2 yr had PBB levels of 2.4 (SD 1.2) and 0.8 (SD 0.65) mg/kg for females and 3.0 (SD 1.6) and 0.6 (SD 0.37) mg/kg for males, respectively. The incidence of hepatocellular carcinomas was 3/51 (5.9%) and 4/41 (9.6%) after 2 yr in females and males, respectively. Hepatocellular carcinomas were not observed among the controls. Neoplastic (hyperplastic) nodules of the liver were present in 9/51 (17.6%) and 2/41 (4.9%) of exposed females and males, respectively, whereas only 2/48 (4.2%) of control females and no control males had neoplastic (hyperplastic) nodules. Body weights were lower in PBB‐exposed rats at ages 1, 6, 12, and 24 mo. Survival rates from birth to weaning were lower in PBB‐exposed pups (89%) than in controls (98%). Mortality was two times higher in PBB‐exposed males (64%) than in control males (32%) after 2 yr. Transplacental PBB exposure and exposure through milk resulted in PBB body burdens in the offspring still measurable at the end of their lifespan. These offspring had increased mortality rates and lower body weights than controls, and they developed hepatocellular carcinomas. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457100; Groce, Donald F. 1; Kimbrough, Renate D. 2; Source Information: Jan1984, Vol. 14 Issue 5/6, p695; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287398409530618
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Olins, Nancy J.
T1 - Utility of Drug Leaflets for Elderly Consumers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/02//
VL - 74
IS - 2
M3 - Article
SP - 157
EP - 158
PB - American Public Health Association
SN - 00900036
AB - A mail survey of 1,650 elderly consumers evaluated prescription drug leaflets for antihypertensives, tranquilizers, and arthritis medicines. Of those who said they received the leaflet, 95 per cent read it, 76 per cent kept it, and 56 per cent discussed it with another person. Respondents taking antihypertensive medicine were more apt to keep the leaflet and say they learned new information from it. Those taking tranquilizers were less likely to say the leaflet made them feel better about using the drug. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacopoeias
KW - Tranquilizing drugs
KW - Social science research
KW - Antihypertensive agents
KW - Cardiovascular agents
KW - United States
N1 - Accession Number: 4953199; Morris, Louis A. 1; Olins, Nancy J. 2; Affiliations: 1: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; 2: American Association of Retired Persons Pharmacy Service; Issue Info: Feb1984, Vol. 74 Issue 2, p157; Subject Term: Pharmacopoeias; Subject Term: Tranquilizing drugs; Subject Term: Social science research; Subject Term: Antihypertensive agents; Subject Term: Cardiovascular agents; Subject: United States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Milligan, B. Carol
T1 - Nursing Care and Beliefs of Expectant Navajo Women (Part 1).
JO - American Indian Quarterly
JF - American Indian Quarterly
Y1 - 1984///Spring1984
VL - 8
IS - 2
M3 - Article
SP - 83
EP - 101
SN - 0095182X
AB - Describes research conducted on the Navajo Indian Reservation to determine the degree of conflict between modern birth-related practices and traditional methods. The sample population is divisible into "traditional," "transitional," and "modern" categories. The acculturation process occurs in discrete stages, and those whose world-view is traditional suffer stress and role conflict over the demands of modern medical practice.
KW - NURSE practitioners
KW - NURSING
KW - PREGNANT women
KW - CULTURE
KW - NAVAJO (North American people)
KW - NEWBORN infants -- Death
KW - WOMEN
KW - MANNERS & customs
KW - INDIGENOUS peoples of the Americas
KW - CHILDBIRTH
KW - ACCULTURATION
KW - NAVAJO Indian Reservation
KW - NEW Mexico
KW - ARIZONA
N1 - Accession Number: 16112430; Milligan, B. Carol 1; Affiliations: 1 : Chief Nurse Midwife, United States Public Health Service, Indian Health Service; Source Info: Spring1984, Vol. 8 Issue 2, p83; Note: Based on field research and secondary sources; 5 tables. Article to be continued.; Historical Period: 1976 to 1980; Subject Term: NURSE practitioners; Subject Term: NURSING; Subject Term: PREGNANT women; Subject Term: CULTURE; Subject Term: NAVAJO (North American people); Subject Term: NEWBORN infants -- Death; Subject Term: WOMEN; Subject Term: MANNERS & customs; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: CHILDBIRTH; Subject Term: ACCULTURATION; Subject: NAVAJO Indian Reservation; Subject: NEW Mexico; Subject: ARIZONA; Number of Pages: 19p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Murphy, Lawrence R.
T1 - Occupational stress management: A review and appraisal.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1984/03//
VL - 57
IS - 1
M3 - Article
SP - 1
EP - 15
PB - Wiley-Blackwell
SN - 03058107
AB - Published and unpublished studies evaluating the merits of occupational stress management are reviewed. Worksite stress management studies are compared along dimensions of type of work group, programme orientation and format, stress management methods, non-specific effects, and long-term maintenance of skills and benefits. Although studies differ widely on these dimensions and too few studies have been conducted to state unequivocally general conclusions, worksite stress management programmes appear to offer promise for helping workers cope with stress and exert greater control over physiological and psychological systems which are reactive to stressors. Troublesome issues in this young research area are noted and future research needs are enumerated. Finally, the advantages and potential disadvantages of worksite stress management programmes are described. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - ORGANIZATIONAL structure
KW - TEAMS in the workplace
KW - STRESS management
KW - MENTAL health
KW - PSYCHOLOGY
N1 - Accession Number: 4618455; Murphy, Lawrence R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Issue Info: Mar1984, Vol. 57 Issue 1, p1; Thesaurus Term: JOB stress; Thesaurus Term: ORGANIZATIONAL structure; Thesaurus Term: TEAMS in the workplace; Subject Term: STRESS management; Subject Term: MENTAL health; Subject Term: PSYCHOLOGY; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1985-06606-001
AN - 1985-06606-001
AU - Holck, Susan E.
AU - Warren, Charles W.
AU - Smith, Jack C.
AU - Rochat, Roger W.
T1 - Alcohol consumption among Mexican American and Anglo women: Results of a survey along the U.S.-Mexico border.
JF - Journal of Studies on Alcohol
JO - Journal of Studies on Alcohol
JA - J Stud Alcohol
Y1 - 1984/03//
VL - 45
IS - 2
SP - 149
EP - 154
CY - US
PB - Alcohol Research Documentation
SN - 0096-882X
N1 - Accession Number: 1985-06606-001. PMID: 6727375 Other Journal Title: Journal of Studies on Alcohol and Drugs; Quarterly Journal of Studies on Alcohol. Partial author list: First Author & Affiliation: Holck, Susan E.; US Public Health Service Centers for Disease Control, Div of Reproductive Health, Atlanta, GA. Release Date: 19850301. Correction Date: 20081124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Human Females; Mexican Americans; Racial and Ethnic Differences; Whites. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 6. Issue Publication Date: Mar, 1984.
AB - Conducted a household probability survey of 1,233 Mexican-American and 798 Anglo women (aged 15–44 yrs) residing along the US/Mexico border. Consistent with findings from previous research, a higher proportion of abstainers was found among the Mexican-Americans than among the Anglos in almost every social and demographic category examined (age, marital status, education, and employment status). Because the level of alcohol consumption increased markedly with the years of education completed, almost all of the overall ethnic differences observed could be accounted for by the generally lower level of education among the Mexican-Americans. However, ethnic subgroups of Mexican-American women reported different levels of alcohol consumption that could not be accounted for by differences in education, suggesting that additional ethnic factors contribute to drinking patterns. (16 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol consumption
KW - 15–44 yr old Mexican American vs White females
KW - 1984
KW - Alcohol Drinking Patterns
KW - Human Females
KW - Mexican Americans
KW - Racial and Ethnic Differences
KW - Whites
KW - 1984
DO - 10.15288/jsa.1984.45.149
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1985-06606-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1985-02708-001
AN - 1985-02708-001
AU - Smith, Alexander B.
AU - Tanaka, Shiro
AU - Halperin, William
AU - Richards, R. D.
T1 - Correlates of ocular and somatic symptoms among video display terminal users.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 1984/04//
VL - 26
IS - 2
SP - 143
EP - 156
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
N1 - Accession Number: 1985-02708-001. PMID: 6479980 Partial author list: First Author & Affiliation: Smith, Alexander B.; US Public Health Service Centers for Disease Control, National Inst for Occupational Safety & Health, Cincinnati, OH. Other Publishers: Sage Publications. Release Date: 19850101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Business and Industrial Personnel; Symptoms; Video Display Units; Working Conditions. Classification: Human Factors Engineering (4010). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 14. Issue Publication Date: Apr, 1984.
AB - Results of a cross-sectional survey conducted among 283 employees of a large newspaper company indicate that poor visual clarity of the video display terminal (VDT) screen explained the plurality of work-associated ocular and somatic symptoms. These associations were independent of the effects of potential confounding variables. The relationships with headaches associated with work and changes in visual function were replicated in an independent sample of 100 employees. One qualitative and 2 quantitative VDT-use variables suggested that lesser skill or experience were associated with headaches. (30 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - factors related to ocular & somatic symptoms
KW - newspaper company employees who use video display terminals
KW - 1984
KW - Business and Industrial Personnel
KW - Symptoms
KW - Video Display Units
KW - Working Conditions
KW - 1984
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1985-02708-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Ringen, Knut
T1 - Notification of Workers at High Risk An Emerging Public Health Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/05//
VL - 74
IS - 5
M3 - Article
SP - 485
EP - 491
PB - American Public Health Association
SN - 00900036
AB - During the last two decades, an increasing number of epidemiologic studies have found cohorts of workers to be at high risk or work-related chronic diseases, especially cancers. These studies frequently have led to the broad recognition of occupational hazards and eventually to the prevention of exposures to such hazards. Generally, however, the individual cohort members found to be at high risk have not been notified of study results, and programs of medical intervention or of palliative services directed at these individual workers have not been developed. Recently, the issue of whether or not workers have a right to be notified more directly about know health hazards to which they may have been exposed has emerged as a major, unresolved question in public health policy. Issues of concern include the criteria that should guide notifications; whom, when, and how to notify; and who should pay for notification and follow-up services. This commentary discusses the scientific, ethical, economic, and institutional aspects of worker notification, and describes three new demonstration projects that have provided notification and intervention for workers at high risk of bladder, colon, and lung cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Occupational hazards
KW - Public health
KW - Occupational health services
KW - Medical policy
KW - Medical care
N1 - Accession Number: 4958846; Schulte, Paul A. 1; Ringen, Knut 2; Affiliations: 1: Epidemiologist, Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226; 2: National Cancer Institute, Division of Resources, Center and Community Activities, Bethesda, MD; Issue Info: May84, Vol. 74 Issue 5, p485; Thesaurus Term: Industrial hygiene; Thesaurus Term: Occupational hazards; Thesaurus Term: Public health; Subject Term: Occupational health services; Subject Term: Medical policy; Subject Term: Medical care; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Snippe, H.
AU - Van Houte, A. J.
AU - Inman, J. K.
AU - Lizzio, Elaine F.
AU - Merchant, B.
T1 - Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.
JO - Immunology
JF - Immunology
Y1 - 1984/05//
VL - 52
IS - 1
M3 - Article
SP - 87
EP - 96
SN - 00192805
AB - CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N × C3H/HeN F1 male > CBA/N female > CBA/N · C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - B cells
KW - ANTIGENS
KW - IMMUNE response
KW - THYMUS
KW - CELL populations
KW - MICE
N1 - Accession Number: 13506619; Snippe, H. 1; Van Houte, A. J. 1; Inman, J. K. 2; Lizzio, Elaine F. 3; Merchant, B. 3; Source Information: May84, Vol. 52 Issue 1, p87; Subject: HAPTENS; Subject: B cells; Subject: ANTIGENS; Subject: IMMUNE response; Subject: THYMUS; Subject: CELL populations; Subject: MICE; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Taylor, Philip R.
AU - Lawrence, Charles E.
AU - Ho-Ling Hwang
AU - Paulson, Albert S.
T1 - Polychlorinated Biphenyls: Influence on Birthweight and Gestation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/10//
VL - 74
IS - 10
M3 - Article
SP - 1153
EP - 1154
PB - American Public Health Association
SN - 00900036
AB - Abstract: Fifty-one infants born to women employed at two capacitor manufacturing facilities with a history of high exposure to polychlorinated biphenyls (PCBs) had a mean birthweight of 153 grams < that of 337 infants born to women who had worked in low-exposure areas (90 per ¢ confidence interval, -286 to -20 g): mean gestational age was 6.6 days shorter in the high-exposure infants (90 per ¢ CI, -10.3 to -2.9 days). After adjusting for gestational age. the difference in birthweight was markedly reduced. indicating that the observed reduction in birthweight was due mainly to shortening of gestational age in the high-exposure group. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polychlorinated biphenyls
KW - Birth weight
KW - Infants -- Care
KW - Gestational age
KW - Mother & infant
KW - Pregnancy
KW - Childbirth
KW - Infants
KW - Infant health services
N1 - Accession Number: 4956365; Taylor, Philip R. 1,2; Lawrence, Charles E. 1; Ho-Ling Hwang 1,3; Paulson, Albert S. 1,3; Affiliations: 1: Director, Statistical and Computer Science Laboratory, New York State Department of Health, Center for Laboratories and Research, Empire State Plaza, Rm C323, Albany, NY 12201; 2: National Institute for Occupational Safety and Health, Center for Disease Control and Harvard School of Public Health; 3: Rensselaer Polytechnic Institute, Troy, NY; Issue Info: Oct84, Vol. 74 Issue 10, p1153; Thesaurus Term: Polychlorinated biphenyls; Subject Term: Birth weight; Subject Term: Infants -- Care; Subject Term: Gestational age; Subject Term: Mother & infant; Subject Term: Pregnancy; Subject Term: Childbirth; Subject Term: Infants; Subject Term: Infant health services; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Grossman, Ruth
AU - Barkdoll, Gerald L.
AU - Gordon, Evelyn
AU - Soviero, Carmin
T1 - A Survey of Patient Sources of Prescription Drug Information.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/10//
VL - 74
IS - 10
M3 - Article
SP - 1161
EP - 1162
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national telephone survey of 1,104 adults who had recently obtained a new prescription was undertaken to determine the nature and amount of drug information obtained. Sixty percent stated that physicians provided directions for use information with the pharmacy reported as about half as active. Only 3 to 6 per ¢ said they asked the physician or pharmacist for information, However, one in six respondents said they looked up the prescription in a drug reference book such as the Physicians Desk Reference. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medicine
KW - Drugs
KW - Prescription of drugs
KW - Medical care surveys
KW - Medical care
KW - Pharmaceutical services
KW - Physicians
KW - Pharmacists
KW - Reference books
N1 - Accession Number: 4956413; Morris, Louis A. 1; Grossman, Ruth 1; Barkdoll, Gerald L. 1; Gordon, Evelyn 1; Soviero, Carmin 1; Affiliations: 1: Food and Drug Administration, Rockville, MD; Issue Info: Oct84, Vol. 74 Issue 10, p1161; Thesaurus Term: Medicine; Thesaurus Term: Drugs; Subject Term: Prescription of drugs; Subject Term: Medical care surveys; Subject Term: Medical care; Subject Term: Pharmaceutical services; Subject Term: Physicians; Subject Term: Pharmacists; Subject Term: Reference books; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Robinson, C. J. Goter
AU - Abraham, A. A.
AU - Balaza, T.
T1 - Induction of anti-nuclear antibodies by mercuric chloride in mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/11//
VL - 58
IS - 2
M3 - Article
SP - 300
EP - 306
SN - 00099104
AB - Mercuric chloride (HgCl2) was administered parentetally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4, Inbred A/J male mice were resistant to the induction of ANA by HgCl2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MERCURIC chloride
KW - MICE as laboratory animals
KW - CHLORIDES
KW - MERCURY compounds
KW - LABORATORY animals
KW - anti-nuclear
KW - antibodies
KW - mercuric chloride.
N1 - Accession Number: 16437359; Robinson, C. J. Goter 1,2; Abraham, A. A. 3; Balaza, T. 1,2; Source Information: Nov1984, Vol. 58 Issue 2, p300; Subject: IMMUNOGLOBULINS; Subject: MERCURIC chloride; Subject: MICE as laboratory animals; Subject: CHLORIDES; Subject: MERCURY compounds; Subject: LABORATORY animals; Author-Supplied Keyword: anti-nuclear; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: mercuric chloride.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Williams, Robert L.
T1 - Vehicular Carbon Monoxide Screening: Identification in a Cross-Cultural Setting of a Substantial Public Health Risk Factor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/01//
VL - 75
IS - 1
M3 - Article
SP - 85
EP - 86
PB - American Public Health Association
SN - 00900036
AB - Abstract: A community program of screening and education for prevention of vehicular carbon monoxide (CO) poisoning among a high-risk population in a cross-cultural setting is presented. The program was developed after two infant deaths in separate incidents of vehicular CO poisoning. The results of the screening show l8.6 per ¢ of vehicles exceeding the Environmental Protection Agency eight-hour standard for CO exposure, and 2.6 per ¢ exceeding the one-hour standard. Extension of such programs to other high-risk populations is recommended. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carbon monoxide -- Physiological effect
KW - Environmental protection -- Standards
KW - Environmental protection -- Research
KW - Environmental policy
KW - Environmental law
KW - Public health
KW - Environmental sciences
KW - Cross-cultural studies
KW - Diseases -- Risk factors
N1 - Accession Number: 4949545; Williams, Robert L. 1; Affiliations: 1: Navajo Area, Indian Health Service, US Public Health Service, PHS Indian Hospital, Crownpoint, NM 87313.; Issue Info: Jan1985, Vol. 75 Issue 1, p85; Thesaurus Term: Carbon monoxide -- Physiological effect; Thesaurus Term: Environmental protection -- Standards; Thesaurus Term: Environmental protection -- Research; Thesaurus Term: Environmental policy; Thesaurus Term: Environmental law; Thesaurus Term: Public health; Thesaurus Term: Environmental sciences; Subject Term: Cross-cultural studies; Subject Term: Diseases -- Risk factors; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 1985-98333-035
AN - 1985-98333-035
AU - Lesser, Arthur J.
ED - Hobbs, Nicholas
ED - Perrin, James M.
ED - Hobbs, Nicholas, (Ed)
ED - Perrin, James M., (Ed)
T1 - Public programs for crippled children.
T2 - Issues in the care of children with chronic illness: A sourcebook on problems, services, and policies.
T3 - Jossey-Bass health series and Jossey-Bass social and behavioral science series
Y1 - 1985///
SP - 733
EP - 757
CY - San Francisco, CA, US
PB - Jossey-Bass
SN - 0-87589-650-2
N1 - Accession Number: 1985-98333-035. Partial author list: First Author & Affiliation: Lesser, Arthur J.; US Public Health Service, Maternal & Child Health Service, Rockville, MD, US. Release Date: 19850101. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-87589-650-2, Hardcover. Language: English. Major Descriptor: Disorders; Government Policy Making; Government Programs; Intellectual Development Disorder. Minor Descriptor: History. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 25.
AB - provides the reader with a history of child health developments from the late 1800s through the early 1970s / points out that the legislation establishing the Children's Bureau constituted the 1st recognition of the federal government's role in public policy promoting the welfare of the nation's children / details the variety of forces that led to the enactment of Title V of the Social Security Act in 1935 / concentrates on Services for Crippled Children, a new program under Title V, and the special projects grants that were provided under its aegis / discusses the relationship of policy developments in the area of mental retardation to those in the Crippled Children's Services and the Maternal and Child Health Programs as well as the children and Youth Projects (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - history of health developments & public programs
KW - crippled children
KW - Mental Retardation
KW - 1985
KW - Disorders
KW - Government Policy Making
KW - Government Programs
KW - Intellectual Development Disorder
KW - History
KW - 1985
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Schleifer, L M
AU - Sauter, S L
T1 - Controlling glare problems in the VDT work environment
JO - Library Hi Tech
JF - Library Hi Tech
Y1 - 1985///
VL - 3
IS - 4
M3 - Article
SP - 21
EP - 25
SN - 07378831
AB - The introduction of video display terminals may exacerbate lighting problems already present in the workplace. The sources and characteristics of glare are described. Glare control measures, including the location and design of lighting systems, managing outdoor light and using screen filters and hoods, are reviewed
KW - VIDEO display terminals
KW - Health
KW - Terminals
N1 - Accession Number: ISTA2100359; Schleifer, L M 1; Sauter, S L; Affiliations: 1 : Dept. of Health and Human Services, Public Health Service, Cincinnati, OH; Source Info: 1985, Vol. 3 Issue 4, p21; Note: Update Code: 2100; Subject Term: VIDEO display terminals; Author-Supplied Keyword: Health; Author-Supplied Keyword: Terminals; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - CHAP
ID - 1985-97062-009
AN - 1985-97062-009
AU - Brown, Bertram S.
ED - Kogan, Robert E.
ED - Salvendy, John T.
ED - Kogan, Robert E., (Ed)
ED - Salvendy, John T., (Ed)
T1 - Psychiatry in the 1980s.
T2 - Outpatient psychiatry: Progress, treatment, prevention.
T3 - POCA perspectives, No. 9
Y1 - 1985///
SP - 120
EP - 130
CY - University, AL, US
PB - The University of Alabama Press
SN - 0-8173-0171-2
N1 - Accession Number: 1985-97062-009. Partial author list: First Author & Affiliation: Brown, Bertram S.; US Public Health Service, Rockville, MD, US. Release Date: 19970501. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8173-0171-2, Hardcover. Language: English. Major Descriptor: History; Psychiatry. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 11.
AB - discuss, in the perspective of an international overview, some of those projected lines that might appear on the graph as we look at psychiatry in the 1980s and beyond / [suggest that] the balance of effort and activity within [psychiatry] varies from country to country and from culture to culture / [discuss how] the role of psychiatry in the realm of sociopolitical leadership has become equally controversial and unresolved / [describe some] concerns about US–USSR psychiatrists, psychiatry, and their relationships to one another (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatry
KW - 1980s
KW - 1985
KW - History
KW - Psychiatry
KW - 1985
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1987-13331-001
AN - 1987-13331-001
AU - Spaulding, John M.
T1 - Recent suicide rates among ten Ojibwa Indian bands in Northwestern Ontario.
JF - Omega: Journal of Death and Dying
JO - Omega: Journal of Death and Dying
JA - Omega (Westport)
Y1 - 1985///1985-1986
VL - 16
IS - 4
SP - 347
EP - 354
CY - US
PB - Baywood Publishing
SN - 0030-2228
SN - 1541-3764
N1 - Accession Number: 1987-13331-001. Partial author list: First Author & Affiliation: Spaulding, John M.; Indian Health Service, Phoenix, AZ. Other Publishers: Sage Publications. Release Date: 19870501. Correction Date: 20150126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Mortality Rate; Suicide. Minor Descriptor: Alcoholism; Drug Usage. Classification: Behavior Disorders & Antisocial Behavior (3230); Substance Abuse & Addiction (3233). Population: Human (10). Location: Canada. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: 1985-1986.
AB - Investigated the rate of completed suicides for 10 Ojibwa (known as Chippewa in the US) Indian bands for the years 1975–1982. Records from Medical Services, Health and Welfare Canada, were reviewed for suicide data, and interviews were conducted with 9 native health workers to corroborate these data. Results indicate an overall rate of 61.7 suicides per 100,000 population. Suicide victims tended to be young males who used firearms as a method. Alcohol or drug use was directly involved in over half of the suicides. (21 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide rate
KW - Ojibwa Indians
KW - implications for role of alcohol or drug use
KW - 1975–82
KW - Canada
KW - 1985
KW - American Indians
KW - Mortality Rate
KW - Suicide
KW - Alcoholism
KW - Drug Usage
KW - 1985
DO - 10.2190/FTCW-VBXA-MR5J-E90P
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Wallace, W. E.
AU - Vallyathan, V.
AU - Keane, M. J.
AU - Robinson, V.
T1 - In vitro biologic toxicity of native and surface‐modified silica and kaolin.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1985/01/02/
VL - 16
IS - 3/4
M3 - Article
SP - 415
EP - 424
SN - 00984108
AB - An in vitro study of the biologic responses of surface‐modified and native silica and kaolin was made to provide comparative information on the supression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (LDH), and lysosomal enzymes β‐N‐acetylglucosaminidase (β‐NAG) and β‐glucuronidase (β‐GLUC) and sheep blood‐cell hemolysis were monitored as indicators of cell membrane damage and cytotoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (DPL) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457199; Wallace, W. E. 1; Vallyathan, V. 2; Keane, M. J. 2; Robinson, V. 2; Source Information: Jan1985, Vol. 16 Issue 3/4, p415; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287398509530751
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Bergeisen, Gershon H.
AU - Hinds, M. Ward
AU - Skaggs, Joseph W.
T1 - A Waterborne Outbreak of Hepatitis A in Meade County, Kentucky.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/02//
VL - 75
IS - 2
M3 - Article
SP - 161
EP - 164
PB - American Public Health Association
SN - 00900036
AB - Abstract: In November 1982. Meade County. Kentucky health officials noted a sudden increase in the incidence of hepatitis A. Using a standardized interview of 73 cases (68 serologically confirmed), and 85 controls (all negative for antibody to hepatitis A virus), the most important risk factor identified was household use of untreated water from a single spring. A dose-response relationship was found for consumption of unboiled spring water, Water samples taken from the spring during the outbreak were contaminated with fecal coliforms. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Water pollution
KW - Contamination of drinking water
KW - Bacterial pollution of water
KW - Hepatitis A
KW - RISK factors
KW - Kentucky
N1 - Accession Number: 4949444; Bergeisen, Gershon H. 1; Hinds, M. Ward 2; Skaggs, Joseph W. 2; Affiliations: 1: Indian Health Service, Bemidji, MN; 2: Department for Health Services, Cabinet for Human Resources, Commonwealth of Kentucky, 275 E. Main Street, Frankfort, KY 40621; Issue Info: Feb1985, Vol. 75 Issue 2, p161; Thesaurus Term: Diseases; Thesaurus Term: Water pollution; Thesaurus Term: Contamination of drinking water; Thesaurus Term: Bacterial pollution of water; Subject Term: Hepatitis A; Subject Term: RISK factors; Subject: Kentucky; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hinds, M. Ward
AU - Skaggs, Joseph W.
AU - Bergeisen, Gershon H.
T1 - Benefit-Cost Analysis of Active Surveillance of Primary Care Physicians for Hepatitis A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/02//
VL - 75
IS - 2
M3 - Article
SP - 176
EP - 177
PB - American Public Health Association
SN - 00900036
AB - Abstract: We identified two random samples of 216 primary care physicians each. In one sample, we made weekly telephone contact for active hepatitis A (HA) surveillance; in the other, we made no such contact (passive surveillance). Appropriate county hearth departments were notified whenever we identified a HA case by active surveillance. Active surveillance was associated with a 2.8-fold increase in reported HA cases compared to passive surveillance. The estimated benefit: cost ratio active/passive surveillance was 2.5:1. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cost effectiveness
KW - Public health
KW - Primary care (Medicine)
KW - Hepatitis A
KW - County health services
KW - Community health services
N1 - Accession Number: 4949456; Hinds, M. Ward 1; Skaggs, Joseph W. 1; Bergeisen, Gershon H. 1,2; Affiliations: 1: Division for Epidemiology, Kentucky Department for Health Services; 2: Indian Health Service, Bemidji, Minnesota; Issue Info: Feb1985, Vol. 75 Issue 2, p176; Thesaurus Term: Cost effectiveness; Thesaurus Term: Public health; Subject Term: Primary care (Medicine); Subject Term: Hepatitis A; Subject Term: County health services; Subject Term: Community health services; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Audet, Michael F.
AU - Johnson, David W.
T1 - Credentialing of Diagnostic X-ray Technologists: A question of Public Health Impact.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/03//
VL - 75
IS - 3
M3 - Article
SP - 270
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper presents estimates of t11,2 number of diagnostic x-ray examinations performed in the United States. the population dose delivered, the percentage of that dose contributed by credentialed and noncredentialed operators, and one measure of performance: collimation of the x-ray beam. An estimated 82 per ¢ of medical x-ray examination:, are performed by voluntarily certified (ARRT or ARCRT) operators. These procedures contribute 90 per ¢ of the radiation dose to the population. Data from the Nationwide Evaluation of X-Ray Trends (NEXT) program indicate that certified operators collimate the x-ray beam somewhat better than noncertified for chest examinations. They also indicate in it difference,; in collimation practices may be attributed to the type of facility as well as to the credentials of the operators. One third of the medical x-ray machines are in states presently requiring licensure of operators. It appears from these estimates that instituting operator licensure in the remaining states may reduce population dose by a maximum of one or two per ¢. (Am J Public Health 1985:75:270-274.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radioscopic diagnosis
KW - Radiologic technologists
KW - Radiologists
KW - Radiation dosimetry
KW - X-ray equipment
KW - Medical personnel -- Licenses
KW - Radiology
KW - Medical care
KW - Radioscopic diagnostic equipment industry
KW - United States
N1 - Accession Number: 4948565; Audet, Michael F. 1; Johnson, David W. 1; Affiliations: 1: Center for Device and Radiological Health, US Food and Drug Administration.; Issue Info: Mar1985, Vol. 75 Issue 3, p270; Subject Term: Radioscopic diagnosis; Subject Term: Radiologic technologists; Subject Term: Radiologists; Subject Term: Radiation dosimetry; Subject Term: X-ray equipment; Subject Term: Medical personnel -- Licenses; Subject Term: Radiology; Subject Term: Medical care; Subject Term: Radioscopic diagnostic equipment industry; Subject: United States; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Volodin, V.
AU - Souchkevitch, G.
AU - Racoveanu, N.
AU - Bergmann, H.
AU - Busemann-Sokole, E.
AU - Delaloye, B.
AU - Dermentzoglou, F.
AU - Georgescu, G.
AU - Herrera, N.
AU - Jasinski, W.
AU - Kasatkin, Y.
AU - Paras, P.
AU - Mould, R.
T1 - World health organisation inter-laboratory comparison study in 12 countries on quality performance of nuclear medicine imaging devices.
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
Y1 - 1985/03//
VL - 10
IS - 5/6
M3 - Article
SP - 193
EP - 197
SN - 03406997
N1 - Accession Number: 71142908; Volodin, V. 1; Souchkevitch, G. 2; Racoveanu, N. 2; Bergmann, H. 3; Busemann-Sokole, E. 4; Delaloye, B. 5; Dermentzoglou, F. 6; Georgescu, G. 7; Herrera, N. 8; Jasinski, W. 9; Kasatkin, Y. 10; Paras, P. 11; Mould, R. 12; Source Information: Mar1985, Vol. 10 Issue 5/6, p193; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/BF00254460
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hurrell Jr., Joseph J.
T1 - Machine-paced work and the Type A behavior pattern.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1985/03//
VL - 58
IS - 1
M3 - Article
SP - 15
EP - 25
PB - Wiley-Blackwell
SN - 03058107
AB - This article examines the moderating effects of the Type A behaviour pattern on the relationship between paced work and psychological (mood) disturbance. The study was part of a broader survey investigation seeking to characterize job stress and health relationships among postal workers engaged in machine-paced letter-sorting operations Data from 2803 paced letter sorters and 2715 non-paced Postal Service employees were analysed in a behaviour pattern × pacing × sex (2 × 2 × 2) design. Paced work was found to have a significant effect on mood state. However, no evidence of a Type A moderating effect was found. Results of the study for males but not females were consistent with Sales' (1969) theory that the Type A person possesses personality traits that predispose self-selection into stressful jobs. It was suggested that future studies of the relationships between pacing and the Type A pattern include multiple measures of the behaviour predisposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - INDUSTRIAL psychology
KW - STRESS (Psychology)
KW - BEHAVIOR
KW - GENDER
KW - HUMAN behavior
N1 - Accession Number: 4615974; Hurrell Jr., Joseph J. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati.; Issue Info: Mar1985, Vol. 58 Issue 1, p15; Thesaurus Term: JOB stress; Thesaurus Term: INDUSTRIAL psychology; Subject Term: STRESS (Psychology); Subject Term: BEHAVIOR; Subject Term: GENDER; Subject Term: HUMAN behavior; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Santaiti, Ben J.
T1 - The Federal Budget Process.
JO - Nursing Economic$
JF - Nursing Economic$
Y1 - 1985/03//Mar/Apr85
VL - 3
IS - 2
M3 - Article
SP - 103
EP - 108
PB - Jannetti Publications, Inc.
SN - 07461739
AB - The article focuses on the need and the development of Federal budget process. When the economic health of the U.S. began to decline a few years ago, increasing attention was focused on the federal budget and the congressional appropriations process. Today, there are three major congressional entities involved in the Federal budget process that ultimately provide cash for disbursements for the numerous government programs. These three entities are legislative spending authorizations, congressional spending resolutions, and appropriations. This article deals mainly with the appropriations part of the process.
KW - BUDGET process
KW - PUBLIC finance
KW - MEDICAL care
KW - DISBURSEMENTS
KW - UNITED States -- Appropriations & expenditures
KW - UNITED States
N1 - Accession Number: 12133062; Santaiti, Ben J. 1; Source Information: Mar/Apr85, Vol. 3 Issue 2, p103; Subject: BUDGET process; Subject: PUBLIC finance; Subject: MEDICAL care; Subject: DISBURSEMENTS; Subject: UNITED States -- Appropriations & expenditures; Geographic Terms: UNITED States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1986-05872-001
AN - 1986-05872-001
AU - Hollingsworth, Elizabeth B.
AU - Patrick, Graham A.
T1 - Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D₂.
JF - Pharmacology, Biochemistry and Behavior
JO - Pharmacology, Biochemistry and Behavior
JA - Pharmacol Biochem Behav
Y1 - 1985/03//
VL - 22
IS - 3
SP - 365
EP - 370
CY - Netherlands
PB - Elsevier Science
SN - 0091-3057
N1 - Accession Number: 1986-05872-001. PMID: 2859604 Partial author list: First Author & Affiliation: Hollingsworth, Elizabeth B.; NIH Dept of Health & Human Services, Public Health Service, Bethesda, MD. Release Date: 19860301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Interactions; Pentobarbital; Prostaglandins; Serotonin; Sleep. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20). Page Count: 6. Issue Publication Date: Mar, 1985.
AB - Investigated the ability of prostaglandin D₂ (PGD₂) to potentiate pentobarbital sleeping time and its interaction with the serotonergic system in male CD/3 mice. The administration of PGD₂ (iv) produced a significant decrease in the spontaneous locomotor activity of Ss 1–25 min postinjection. PGD₂ also potentiated pentobarbital sleeping time at iv doses of 0.4 and 4.0 mg/kg. Distribution studies with –3H-PGD₂ (6 μCi, 4 mg/kg) showed that only 0.04% of the tritium administered could be found in the brain at 5 min postinjection and that only 50% of this was parent –3H-PGD₂. The role of the serotonergic neurotransmitter system in the depressant action of PGD₂ was investigated with drugs that modulate this system. The ability of PGD₂ to potentiate pentobarbital sleeping time was diminished by pretreatment with agents that reduce brain level or synthesis rate of serotonin. Such agents included para-chlorophenylalamine (PCPA), a tryptophan hydroxylase inhibitor; 5,7-dihydroxytryptamine (5,7-DHT), a neurotoxin with selectivity for serotonergic neurons; and quipazine, a serotonergic autoreceptor stimulant. Pretreatment with 5-HTP, the precursor of serotonin, further enhanced the potentiation of pentobarbital sleeping time by PGD₂. These data suggest that the depressant actions of PGD₂ are linked to the serotonergic neurotransmitter system. (31 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prostaglandin
KW - pentobarbital sleeping time & serotonergic system
KW - male mice
KW - 1985
KW - Drug Interactions
KW - Pentobarbital
KW - Prostaglandins
KW - Serotonin
KW - Sleep
KW - Mice
KW - 1985
DO - 10.1016/0091-3057(85)90033-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1986-05872-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1986-05871-001
AN - 1986-05871-001
AU - Hollingsworth, Elizabeth B.
AU - Patrick, Graham A.
T1 - The effects produced by prostaglandin D₂ on serotonin turnover and release and tryptophan uptake.
JF - Pharmacology, Biochemistry and Behavior
JO - Pharmacology, Biochemistry and Behavior
JA - Pharmacol Biochem Behav
Y1 - 1985/03//
VL - 22
IS - 3
SP - 371
EP - 375
CY - Netherlands
PB - Elsevier Science
SN - 0091-3057
N1 - Accession Number: 1986-05871-001. PMID: 2581275 Partial author list: First Author & Affiliation: Hollingsworth, Elizabeth B.; NIH Dept of Health & Human Services, Public Health Service, Bethesda, MD. Release Date: 19860301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neurochemistry; Prostaglandins; Serotonin; Tryptophan. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20). Page Count: 5. Issue Publication Date: Mar, 1985.
AB - Investigated the actions of prostaglandin D₂ (PGD₂) on neuronal tryptophan uptake, serotonin uptake and release, and serum tryptophan levels in male CD/3 mice. Results indicate that uptake of –3H-tryptophan in synaptosomes was neither stimulated nor depressed by (10–42 to 10–22 M) PGD₂. There was also no change in serum tryptophan levels after administration of PGD₂. Thus, PGD₂ administration does affect the serotonergic system but no direct neurochemical correlate of sedation can be shown. (19 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prostaglandin
KW - neuronal tryptophan & serotonin uptake & release & serum tryptophan levels
KW - male mice
KW - 1985
KW - Neurochemistry
KW - Prostaglandins
KW - Serotonin
KW - Tryptophan
KW - Mice
KW - 1985
DO - 10.1016/0091-3057(85)90034-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1986-05871-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1986-08924-001
AN - 1986-08924-001
AU - Boondas, Jennifer
T1 - The despair of the homeless aged.
JF - Journal of Gerontological Nursing
JO - Journal of Gerontological Nursing
JA - J Gerontol Nurs
Y1 - 1985/04//
VL - 11
IS - 4
SP - 8
EP - 13
CY - US
PB - SLACK
SN - 0098-9134
N1 - Accession Number: 1986-08924-001. PMID: 3845953 Partial author list: First Author & Affiliation: Boondas, Jennifer; US Dept of Health & Human Services, Public Health Service Div of Nursing, Rockville, MD. Release Date: 19860401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disadvantaged. Classification: Social Processes & Social Issues (2900). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Page Count: 6. Issue Publication Date: Apr, 1985.
AB - Examines problems of the homeless elderly in terms of disengagement theory. It is noted that, whereas the average elderly person disengages from society without interference from meeting the basic human needs of food, shelter, and clothing, the homeless aged person faces an extreme threat to meeting these basic needs. Factors described as contributors to the existence of the homeless aged include deinstitutionalization in the late 1950's, the shortage of affordable housing, and the increase in poverty among the elderly. Recommendations for improving the present situation include meeting emergency needs, providing transitional accommodations, and providing long-term support. (10 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - causes & needs & application of disengagement theory
KW - homeless aged
KW - 1985
KW - Disadvantaged
KW - 1985
DO - 10.3928/0098-9134-19850401-05
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1986-08924-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Horan, John M.
AU - Kurt, Thomas L.
AU - Landrigan, Philip J.
AU - Melius, James M.
AU - Singal, Michael
T1 - Neurologic Dysfunction From Exposure to 2-t-Butylazo-2-Hydroxy-5-Methylhexane (BHMH): A New Occupational Neuropathy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/05//
VL - 75
IS - 5
M3 - Article
SP - 513
EP - 517
PB - American Public Health Association
SN - 00900036
AB - Seven cases of subacute central and peripheral neurologic dysfunction developed in 18 workers employed in the manufacture of reinforced plastic bathtubs. Cases were characterized by weight loss, dizziness, paresthesias, muscle weakness, incontinence, memory loss, and loss of peripheral, color, and night vision. Neuropathies began distally, involved both sensory and motor function, and were associated with prolonged sensory latency, muscle fibrillation, and reduced numbers of functioning motor units. One patient developed posterior lenticular cataracts. Story improvement occurred on removal from exposure, but residual neuropathies persisted for as long as two year. Epidemiologic investigation disclosed that the first case developed approximately two weeks after introduction of it new plastic foaming agent. 2-t-butylazo-2hydroxy-5-methylhexane (BHMH). All cases occurred in workers exposed directly to BHMH. No new cases developed after use of BHMH was discontinued. A survey of the firm which produced BHMH and of 68 user firms found two additional clusters of mild neuropathy which may have been caused by BHMH. BHMH was withdrawn from distribution following discovery of these cases. Subsequently. BHMH has been shown in rats to be a potent neurotoxin. Adequate premarket testing could have averted this outbreak. (Am J Public Health 1985, 75:513-517.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Industrial safety
KW - Aliphatic compounds
KW - Neuropathy
KW - Nervous system
KW - Neurologic manifestations of general diseases
KW - Industrial workers
KW - Employee health promotion
KW - United States
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 4949303; Horan, John M. 1; Kurt, Thomas L. 2; Landrigan, Philip J. 1; Melius, James M. 1; Singal, Michael 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Acid Studies, National Institute for Occupational Safety and Health, Cincinnati.; 2: Department of Internal Medicine, University of Tens Health Science Center and North Central Texas Poison Center, Parkland Memorial Hospital, Dallas.; Issue Info: May85, Vol. 75 Issue 5, p513; Thesaurus Term: DISEASES; Thesaurus Term: Industrial safety; Thesaurus Term: Aliphatic compounds; Subject Term: Neuropathy; Subject Term: Nervous system; Subject Term: Neurologic manifestations of general diseases; Subject Term: Industrial workers; Subject Term: Employee health promotion; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Budnick, Lawrence D.
AU - Ross, David A.
T1 - Bathtub-Related Drownings in the United States, 1979-81.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/06//
VL - 75
IS - 6
M3 - Article
SP - 630
EP - 633
PB - American Public Health Association
SN - 00900036
AB - We analyzed National Center for Health Statistics data on drownings in bathtubs and Consumer Product Safety Commission data on bathtub-related injuries for the years 1979-80 and 1979-81, respectively. Seven hundred ten persons drowned in bathtubs in 1979 and 1980, for a crude mortality rate of 1.6 per million persons per year. Although there was an excess of deaths in the spring, there was no important seasonal trend. Mortality rates in the Pacific and Mountain states were higher than in other states. Persons at the extremes of age were al greatest risk of death, with mortality rates of 5-6 per million per year, Black males aged 20-64 years had substantially elevated mortality rates compared to White males. The prevalence of personal risk indicators varied with age, with a frequent history of being left unattended among children less than 5 years old, a frequent history of seizures among persons 5-39 years old, and frequent history of alcohol or drug use among persons 40-59 years old, and frequent evidence of having fallen among those at least 60 years old. Bathtubs are potentially dangerous, and the prevention of drownings in them can be approached through a combination of passive and active strategies. (Am J Public Health 1985: 75:630-633.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drowning
KW - Accidents
KW - Death -- Causes
KW - Bathtubs
KW - Product safety
KW - Government agencies
KW - United States
KW - U.S. Consumer Product Safety Commission
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 4949373; Budnick, Lawrence D. 1; Ross, David A. 1; Affiliations: 1: Special Studies Branch, Chronic Diseases Division, Center for Environmental Health, Center for Disease Control, Public Health Services, US Department of Health and Human Services, Atlanta, Georgia 30333.; Issue Info: Jun85, Vol. 75 Issue 6, p630; Subject Term: Drowning; Subject Term: Accidents; Subject Term: Death -- Causes; Subject Term: Bathtubs; Subject Term: Product safety; Subject Term: Government agencies; Subject: United States ; Company/Entity: U.S. Consumer Product Safety Commission ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 238390 Other Building Finishing Contractors; NAICS/Industry Codes: 416120 Plumbing, heating and air-conditioning equipment and supplies merchant wholesalers; NAICS/Industry Codes: 326191 Plastics Plumbing Fixture Manufacturing; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cafferata, Gail Lee
T1 - The Elderly's Private Insurance Coverage of Nursing Home Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/06//
VL - 75
IS - 6
M3 - Article
SP - 655
EP - 656
PB - American Public Health Association
SN - 00900036
AB - About 40 per cent of Medicare beneficiaries had private insurance coverage of skilled nursing facilities (SNF) in 1977. Data from the 1977 National Medical Care Expenditure Survey show that among such persons, about 85 per cent had full coverage of Medicare's Part A copayments for days 21-100 but only 15.7 per cent had maximum coverage of at least 365 days of care or a benefit of $100.000 or more. The most comprehensive benefits are found among persons with middle or high incomes: more generous first-dollar coverage is found in the North Central and South regions, and more generous maximums in the West. (Am d Public Health 1985; 75:655-656.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medicare
KW - Health insurance
KW - Medicare beneficiaries
KW - Older people -- Care
KW - Nursing care facilities
KW - Health facilities
KW - Nursing home care
KW - Long-term care of the sick
KW - United States
N1 - Accession Number: 4949393; Cafferata, Gail Lee 1; Affiliations: 1: Sociologist, National Center for Health Services Research and Health Care Technology Assessment (NCHRS), US Department of Health and Human Services, 5600 Fishers Lane 3-50, Rockville, MD 20857.; Issue Info: Jun85, Vol. 75 Issue 6, p655; Subject Term: Medicare; Subject Term: Health insurance; Subject Term: Medicare beneficiaries; Subject Term: Older people -- Care; Subject Term: Nursing care facilities; Subject Term: Health facilities; Subject Term: Nursing home care; Subject Term: Long-term care of the sick; Subject: United States; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1985-28386-001
AN - 1985-28386-001
AU - Stewart, Joseph L.
T1 - Stuttering Indians: A reply to Zimmermann et al.
JF - Journal of Speech & Hearing Research
JO - Journal of Speech & Hearing Research
JA - J Speech Hear Res
Y1 - 1985/06//
VL - 28
IS - 2
SP - 313
EP - 315
CY - US
PB - American Speech-Language-Hearing Assn
SN - 0022-4685
N1 - Accession Number: 1985-28386-001. Other Journal Title: Journal of Speech, Language, and Hearing Research. Partial author list: First Author & Affiliation: Stewart, Joseph L.; Indian Health Service, Albuquerque, NM. Release Date: 19851101. Correction Date: 20170309. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: American Indians; Stuttering. Classification: Speech & Language Disorders (3270). Population: Human (10). Page Count: 3. Issue Publication Date: Jun, 1985.
AB - Argues that data in the research note published by G. Zimmermann et al (see record [rid]1984-23501-001[/rid]) on the problem of stuttering among American Indians, which was based on correspondence among the present author and other colleagues, are incomplete. The present author notes that Zimmermann did not have the entire file of correspondence in his possession; therefore, certain conclusions by Zimmermann et al are unsubstantiated and irrelevant. (6 ref) (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - stuttering
KW - American Indians
KW - criticism of research note by G. Zimmermann et al
KW - 1985
KW - American Indians
KW - Stuttering
KW - 1985
DO - 10.1044/jshr.2802.313
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1985-28386-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1986-12314-001
AN - 1986-12314-001
AU - Cytryn, Leon
AU - McKnew, Donald H.
T1 - Treatment issues in childhood depression.
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 1985/06//
VL - 15
IS - 6
SP - 401
EP - 403
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
N1 - Accession Number: 1986-12314-001. Partial author list: First Author & Affiliation: Cytryn, Leon; NIH, Public Health Service, Bethesda, MD. Release Date: 19860501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Depression (Emotion); Treatment. Minor Descriptor: Cognitive Therapy; Drug Therapy; Family Therapy; Psychotherapy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Page Count: 3. Issue Publication Date: Jun, 1985.
AB - Examines several methods of therapy for childhood depression. The goal of therapy is described as helping the patient reach the highest level of functioning achievable, while alleviating mental pain or anguish. The following therapies are discussed with relation to procedures and situational appropriateness: psychotherapy, cognitive therapy, family therapy, parent therapy, individual therapy with the child, community collaboration, and antidepressant and lithium therapy. (13 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment methods
KW - childhood depression
KW - 1985
KW - Depression (Emotion)
KW - Treatment
KW - Cognitive Therapy
KW - Drug Therapy
KW - Family Therapy
KW - Psychotherapy
KW - 1985
DO - 10.3928/0048-5713-19850601-11
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1986-12314-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12271-024
AN - 2007-12271-024
AU - Nicks, T. Leon
T1 - Inequities in the delivery and financing of mental health services for ethnic minority Americans.
T3 - Psychotherapy with Ethnic Minorities
JF - Psychotherapy: Theory, Research, Practice, Training
JO - Psychotherapy: Theory, Research, Practice, Training
JA - Psychotherapy (Chic)
Y1 - 1985///Sum 1985
VL - 22
IS - 2S
SP - 469
EP - 476
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
SN - 1939-1536
AD - Nicks, T. Leon, Department of Health and Human Services, Public Health Service, DHSD, ROI Room 1401, JFK Federal Building, Boston, MA, US, 02203
N1 - Accession Number: 2007-12271-024. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research & Practice. Partial author list: First Author & Affiliation: Nicks, T. Leon; U.S. Public Health Service, Boston, MA, US. Other Publishers: Educational Publishing Foundation. Release Date: 20070813. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Government; Mental Health Services; Minority Groups; Public Health. Minor Descriptor: Funding; Health Care Delivery. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 8. Issue Publication Date: Sum 1985. Copyright Statement: Division of Psychotherapy (29), American Psychological Association. 1985.
AB - This article discusses the federal and state responsibilities for providing mental health services to those least able to afford such services. Programs for financing the services by the government suggest that many needs and possible inadequacies exist in our present system which should be made more responsive to populations requiring services. This article reflects the author's views and might not necessarily reflect the U.S. Public Health Service's views or policies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - service delivery
KW - financing
KW - ethnic minority Americans
KW - government
KW - 1985
KW - Government
KW - Mental Health Services
KW - Minority Groups
KW - Public Health
KW - Funding
KW - Health Care Delivery
KW - 1985
DO - 10.1037/h0085532
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12271-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Broido, Michelle S.
AU - James, Thomas L.
AU - Zon, Gerald
AU - Keepers, Joe W.
T1 - Investigation of the solution structure of a DNA octamer [d(GGAATTCC)]2 using two-dimenstional nuclear Overhauser enhancement spectroscopy.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/07//7/1/85
VL - 150
IS - 1
M3 - Article
SP - 117
EP - 128
SN - 00142956
AB - Proton two-dimensional nuclear Overhauser enhancement (2D NOE) spectra in the pure absorption phase were obtained at 500 MHz for [d(GGAATTCC)]2 in aqueous solution at a series of mixing times. The experimental data were analyzed by comparison with theoretical spectra calculated using the complete 70 × 70 relaxation matrix including all proton dipole-dipole interactions and spin diffusion [Keepers, J. W. & James, T. L. (1984) J. Magn. Resort. 57, 404–426]. The theoretical spectra at each mixing time were calculated using two structures: a standard B-form DNA structure and an energy-minimized structure based on the similarity of the six internal residues of the title octamer with those of the dodecamer [d(CGCGAATTCGCG)]2, for which the crystal structure has been determined. Neither the standard B-form nor the energy-minimized structure will yield theoretical 2D NOE spectra which accurately reproduce all peak intensities in the experimental spectra. However, many features of the experimental spectra can be represented by both the B-form and the energy-minimized structure. Sequence-dependent structural characteristics are manifest in the 2D NOE spectra, in particular at the purine-pyrimidine junction as noted previously in the crystal structure. On the whole, the energy-minimized structure appears to yield theoretical 2D NOE spectra which mimic many, if not all, aspects of the experimental spectra. All 2D NOE data were consistent with nanosecond correction times as implied by proton spin-lattice relaxation time measurements. But better fits of some of the 2D NOE data using small variations in an effective isotropic correlation time suggest that there may be some local variations in mobility within the octamer duplex structure in solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA synthesis
KW - SPIN-lattice relaxation
KW - NUCLEAR magnetic resonance
KW - DIPOLE moments
KW - PHOTON echoes
KW - PURINES
KW - PYRIMIDINES
N1 - Accession Number: 13871945; Broido, Michelle S. 1; James, Thomas L. 2; Zon, Gerald 3; Keepers, Joe W. 4; Source Information: 7/1/85, Vol. 150 Issue 1, p117; Subject: DNA synthesis; Subject: SPIN-lattice relaxation; Subject: NUCLEAR magnetic resonance; Subject: DIPOLE moments; Subject: PHOTON echoes; Subject: PURINES; Subject: PYRIMIDINES; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Bernzweig, Eli P.
T1 - When the nurse is her own worst enemy.
JO - RN
JF - RN
Y1 - 1985/07//
VL - 48
IS - 7
M3 - Article
SP - 53
EP - 54
SN - 00337021
AB - Identifies the characteristics of lawsuit-prone nurses in the U.S. Case example of nursing negligence; Need for nurses to develop interpersonal skills; Patient care considerations.
KW - NURSES -- Attitudes
KW - NURSING ethics
N1 - Accession Number: 4939598; Bernzweig, Eli P. 1; Source Information: Jul85, Vol. 48 Issue 7, p53; Subject: NURSES -- Attitudes; Subject: NURSING ethics; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1042
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Attico, N. Burton
AU - Smith III, Richard J.
AU - FitzPatrick, Michael B.
AU - Keneally, Michael
AU - Friedman, Michael A.
T1 - Auto Seat Belts: Good Prenatal, Postpartum, and Infant Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/08//
VL - 75
IS - 8
M3 - Letter
SP - 892
EP - 893
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article on the use of seat belts by pregnant women to reduce serious injuries and death.
KW - Letters to the editor
KW - Automobile seat belts
N1 - Accession Number: 21096259; Attico, N. Burton 1; Smith III, Richard J. 1; FitzPatrick, Michael B. 1; Keneally, Michael 1; Friedman, Michael A. 1; Affiliations: 1: Phoenix Area Indian Health Service, 3738 No. Sixteenth Street, Suite #A, Phoenix, AZ; Issue Info: Aug1985, Vol. 75 Issue 8, p892; Subject Term: Letters to the editor; Subject Term: Automobile seat belts; NAICS/Industry Codes: 316998 All Other Leather Good and Allied Product Manufacturing; NAICS/Industry Codes: 326220 Rubber and Plastics Hoses and Belting Manufacturing; NAICS/Industry Codes: 336360 Motor Vehicle Seating and Interior Trim Manufacturing; NAICS/Industry Codes: 415290 Other new motor vehicle parts and accessories merchant wholesalers; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bernzweig, Eli P.
T1 - The right way to report a colleague.
JO - RN
JF - RN
Y1 - 1985/08//
VL - 48
IS - 8
M3 - Article
SP - 55
EP - 56
SN - 00337021
AB - Discusses guidelines in reporting nurse misconduct. Presentation of the facts; Disclosure of the nurse's misconduct.
KW - NURSING
KW - NURSES
N1 - Accession Number: 4939508; Bernzweig, Eli P. 1,2; Source Information: Aug85, Vol. 48 Issue 8, p55; Subject: NURSING; Subject: NURSES; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 814
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Wade, Michael J.
T1 - The Methylxanthine Beverages and Foods: Chemistry, Consumption and Health Effects.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1985/09//
VL - 42
IS - 3
M3 - Book Review
SP - 575
EP - 576
SN - 00029165
KW - Methylxanthines
KW - Nonfiction
KW - Spiller, Gene A.
KW - Methylxanthine Beverages & Foods: Chemistry, Consumption & Health Effects (Book)
N1 - Accession Number: 91912254; Wade, Michael J. 1; Affiliations: 1: Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204; Issue Info: Sep1985, Vol. 42 Issue 3, p575; Subject Term: Methylxanthines; Subject Term: Nonfiction; Reviews & Products: Methylxanthine Beverages & Foods: Chemistry, Consumption & Health Effects (Book); People: Spiller, Gene A.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Sanford A.
AU - Stephenson, Marilyn G.
T1 - Scientific and public health rationale for the dietary guidelines for Americans.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1985/10//
VL - 42
IS - 4
M3 - Article
SP - 739
EP - 745
SN - 00029165
AB - The Dietary Guidelines for Americans, published by DHHS and USDA in 1980, have recently been reviewed by an expert committee that has recommended only minimal changes to scientifically update them. Initial efforts to develop dietary guidelines for prevention of diseases were fraught with controversy, some of which has continued. This controversy exemplifies a larger issue concerning the role that contemporary science, and specifically government, has in assuring and maintaining public health. Two broad questions need to be asked: what is the government's role in facilitating application of contemporary nutrition knowledge to public health, and what standard of scientific surety should be the basis for its application? Government's role in assuring public health and safety indirectly through information is well established. In deciding when the data are sufficient to inform the public, public health scientists must, at some point, make the leap of faith, even though some doubts may remain. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health products
KW - Holistic medicine
KW - Health behavior
KW - Longevity
KW - Hygiene
KW - diet and disease
KW - Dietary guidelines
KW - public health policy
N1 - Accession Number: 91548499; Miller, Sanford A. 1; Stephenson, Marilyn G. 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Oct1985, Vol. 42 Issue 4, p739; Subject Term: Health products; Subject Term: Holistic medicine; Subject Term: Health behavior; Subject Term: Longevity; Subject Term: Hygiene; Author-Supplied Keyword: diet and disease; Author-Supplied Keyword: Dietary guidelines; Author-Supplied Keyword: public health policy; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Grimes, David A.
AU - Peterson, Herbert B.
T1 - On Risks, Costs of Sterilization.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/10//
VL - 75
IS - 10
M3 - Letter
SP - 1230
EP - 1230
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Comparative Risks and Costs of Male and Female Sterilization," by Gregory L. Smith and George P. Taylor.
KW - Sterilization (Disinfection)
KW - Letters to the editor
N1 - Accession Number: 21096150; Grimes, David A. 1; Peterson, Herbert B. 1; Affiliations: 1: DHHS, Public Health Service, Centers for Disease Control, Atlanta, GA 30333; Issue Info: Oct85, Vol. 75 Issue 10, p1230; Thesaurus Term: Sterilization (Disinfection); Subject Term: Letters to the editor; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jamin, Nadege
AU - James, Thomas L.
AU - Zon, Gerald
T1 - Two-dimensional nuclear Overhauser enhancement investigation of the solution structure and dynamics of the DNA octamer [d(GGTATACC)]2.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/10//10/1/85
VL - 152
IS - 1
M3 - Article
SP - 157
EP - 166
SN - 00142956
AB - The resonances of nearly all 70 of the non-exchangeable protons of the duplex [d(GGTATACC)]2 in aqueous solution are assigned by proton two-dimensional nuclear Overhauser enhancement (2D NOE) spectra obtained in pure absorption phase at 500 MHz. Experimental and theoretical 2D NOE spectra are compared at each mixing time (100, 175, 250 and 400 ms) using two B-DNA structures: a standard B-form and an energy-minimized form. The GG and CC ends of the octamer duplex are well represented by the regular B-DNA structure. But large discrepancies from these models are observed for the ‘TATA’ box. All 2D NOE data are consistent with nanosecond correlation times, as indicated by non-selective proton spin-lattice relaxation times, but small variations in the correlation time are observed, suggesting that there are some local differences in mobility within the octamer duplex structure in solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVERHAUSER effect (Nuclear physics)
KW - SPIN-lattice relaxation
KW - NUCLEAR magnetic resonance
KW - DNA
KW - PROTONS
KW - OLIGONUCLEOTIDES
N1 - Accession Number: 13873484; Jamin, Nadege 1; James, Thomas L. 1; Zon, Gerald 2; Source Information: 10/1/85, Vol. 152 Issue 1, p157; Subject: OVERHAUSER effect (Nuclear physics); Subject: SPIN-lattice relaxation; Subject: NUCLEAR magnetic resonance; Subject: DNA; Subject: PROTONS; Subject: OLIGONUCLEOTIDES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Ruffner, Michael
AU - Klimberg, Ronald
T1 - Warnings Disclosures for Prescription Drugs.
JO - Journal of Advertising Research
JF - Journal of Advertising Research
Y1 - 1985/10//Oct/Nov85
VL - 25
IS - 5
M3 - Article
SP - 25
EP - 32
SN - 00218499
AB - The article examines global reactions of consumers to prototype advertisements that varied in the specificity, amount, and emphasis provided to risk information about prescription drugs. The affirmative disclosure of product limitations and warnings has gained considerable attention among public policy makers as a means of adequately protecting the public. Not only do warning messages convey specific facts, they may also foster impressions about the product that may influence consumer's perceptions. The present study investigated the global reactions of consumers to various ways of structuring warning information in prototypical product advertising. Television advertising for products that pose risks has occasionally been restricted or the risks have been addressed in separate advertisements developed by the manufacturer, counter-advocacy groups, or nonprofit/government institutions. However, in recent years a number of attempts have been made to incorporate warning/precautionary information into promotional advertisements. The inclusion of warning information, as opposed to product limitations, has focused primarily on health care products such as over-the-counter and prescription medication.
KW - ADVERTISING
KW - CONSUMER behavior
KW - TELEVISION broadcasting
KW - MEDICAL care
KW - TELEVISION commercials
KW - DRUGS
KW - WARNINGS
N1 - Accession Number: 6630459; Morris, Louis A. 1,2; Ruffner, Michael 3; Klimberg, Ronald 4,5; Affiliations: 1: Psychologist and Chief of the Food and Drug Administration's Drug Education, Research and Labeling Branch.; 2: Adjunct Professor of Marketing at American University and Teaches Part Time, University of Maryland.; 3: Director of Corporate Marketing Research at CBS Inc.; 4: Operations Research Analyst at the Food and Drug Administration.; 5: The Johns Hopkins University.; Issue Info: Oct/Nov85, Vol. 25 Issue 5, p25; Thesaurus Term: ADVERTISING; Thesaurus Term: CONSUMER behavior; Thesaurus Term: TELEVISION broadcasting; Thesaurus Term: MEDICAL care; Thesaurus Term: TELEVISION commercials; Subject Term: DRUGS; Subject Term: WARNINGS; NAICS/Industry Codes: 334220 Radio and Television Broadcasting and Wireless Communications Equipment Manufacturing; NAICS/Industry Codes: 515120 Television Broadcasting; NAICS/Industry Codes: 512110 Motion Picture and Video Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Schaeffer, Morris
T1 - William H. Park (1863-1939): His Laboratory and His Legacy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/11//
VL - 75
IS - 11
M3 - Article
SP - 1296
EP - 1302
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the works of U.S. bacteriologist William H. Park during the 19th and early 20th centuries. Park's interest in the high infant mortality rate from the consumption of heavily contaminated milk turned him into the leading authority in the development of methods for the bacterial control of milk supplies. He was also known for being among the first to recognize the existence of healthy carriers of microbial agents. He urged New York financier Jeremiah Milbank to support the establishment of the International Committee for the Study of Infantile Paralysis in 1928.
KW - Communicable diseases -- Transmission
KW - Bacteriologists
KW - Infant mortality
KW - Polio
KW - United States
KW - Park, William H.
N1 - Accession Number: 4947440; Schaeffer, Morris 1; Affiliations: 1: Center for Drugs and Biologics, Food and Drug Administration; Issue Info: Nov85, Vol. 75 Issue 11, p1296; Thesaurus Term: Communicable diseases -- Transmission; Subject Term: Bacteriologists; Subject Term: Infant mortality; Subject Term: Polio; Subject: United States; People: Park, William H.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Toraason, M.;
AU - Stringer, B.;
AU - Smith, R.;
T1 - Ornithine decarboxylase activity in the neonatal rat heart following prenatal exposure to ethylene glycol monomethyl ether
CT - Ornithine decarboxylase activity in the neonatal rat heart following prenatal exposure to ethylene glycol monomethyl ether
JO - Drug and Chemical Toxicology (USA)
JF - Drug and Chemical Toxicology (USA)
Y1 - 1986/01/01/
VL - 9
IS - Jan
SP - 1
EP - 4
SN - 01480545
AD - Ctr. for Disease Control, US Public Health Service, Natl. Inst. for Occupational Safety and Health, Div. of Biomed. and Behavioral Sci., Robert A. Taft Lab., 4676 Columbia Pkwy, Cincinnati, OH 45226
N1 - Accession Number: 24-04089; Language: English; Trade Name: Ethylene glycol monomethyl ether; Generic Name: Methoxyethanol; Chemical Name: Methoxyethanol--109-86-4; References: 32; Journal Coden: DCTODJ; Section Heading: Pharmacology; Abstract Author: Victor Origoni
N2 - Basal (nonstimulated) heart ornithine decarboxylase activity and ornithine decarboxylase activity following an isoproterenol challenge were used to assess the effects of prenatal methoxyethanol (ethylene glycol monomethyl ether) exposure on heart function in neonatal rats. In 3-day-old rats exposed on days 13-19 of gestation, ornithine decarboxylase activity was 54% of that found in controls.
KW - Methoxyethanol--effects-;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Courtney, K. Diane
AU - Andrews, James E.
AU - Springer, Janet
T1 - Assessment of teratogenic potential of trichlorfon in mice and rats.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 1986/01/03/
VL - 21
IS - 3
M3 - Article
SP - 207
EP - 227
SN - 03601234
AB - Trichlorfon was evaluated for its teratogenic potential in the CD‐1 mouse at doses of 200, 300 or 400 mg/kg/day administered by gavage on days 7–16 of gestation. In the CD‐1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100 or 200 mg/kg/day to CD rats by gavage on gestational days 7–19 (study I) or 8–20 (study II). In the CD rat in both study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls at the lowest and highest dose levels. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75387307; Courtney, K. Diane 1; Andrews, James E. 1; Springer, Janet 2; Affiliations: 1: Toxicology Branch, Inhalation Toxicology Division, Health Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, 27711; 2: Epidemiology and Clinical Toxicology Unit, Food and Drug Administration, Bureau of Foods, Washington, DC, 20204; Issue Info: Jan1986, Vol. 21 Issue 3, p207; Number of Pages: 21p; Document Type: Article
L3 - 10.1080/03601238609372519
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1987-10721-001
AN - 1987-10721-001
AU - Darrow, William W.
AU - Jaffe, Harold W.
AU - Thomas, Pauline A.
AU - Haverkos, Harry W.
AU - Rogers, Martha F.
AU - Guinan, Mary E.
AU - Auerbach, David M.
AU - Spira, Thomas J.
AU - Curran, James W.
T1 - Sex of interviewer, place of interview, and responses of homosexual men to sensitive questions.
JF - Archives of Sexual Behavior
JO - Archives of Sexual Behavior
JA - Arch Sex Behav
Y1 - 1986/02//
VL - 15
IS - 1
SP - 79
EP - 88
CY - Germany
PB - Springer
SN - 0004-0002
SN - 1573-2800
N1 - Accession Number: 1987-10721-001. PMID: 3964072 Partial author list: First Author & Affiliation: Darrow, William W.; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control AIDS Program, Atlanta, GA. Release Date: 19870401. Correction Date: 20130916. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: Annual Meeting of the International Academy of Sex Research (1983, Harriman, New York). Major Descriptor: Immunologic Disorders; Interviews; Male Homosexuality; Self-Disclosure. Minor Descriptor: Data Collection; Environment. Classification: Immunological Disorders (3291). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Interview. Page Count: 10. Issue Publication Date: Feb, 1986.
AB - Studied effects of sex of interviewer and place of interview on the responses of 57 homosexual acquired immune deficiency syndrome (AIDS) patients and 145 other homosexual men (controls), in 4 cities. Data on sensitive topics were collected by 5 male and 3 female medical officers (aged 29–40 yrs) at places convenient to Ss. Male physicians recorded reports of fellatio more frequently, but female physicians recorded younger ages of initiating homosexual activities and more frequent use of certain recreational drugs (e.g., cocaine and LSD). These differences were due to different patterns of sexual contact and drug use in 4 cities. AIDS patients were interviewed in hospitals and doctor's offices, and controls were interviewed in hotel rooms. Although data collection procedures should maximize reliable communication between interviewer and respondent, much of the initial concern about characteristics of interviewers and the interview setting appeared to be unwarranted. (11 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex of interviewer &/vs place of interview
KW - responses to sensitive questions
KW - homosexual males with acquired immune deficiency syndrome
KW - conference presentation
KW - 1986
KW - Immunologic Disorders
KW - Interviews
KW - Male Homosexuality
KW - Self-Disclosure
KW - Data Collection
KW - Environment
KW - 1986
DO - 10.1007/BF01542306
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Nutting, Paul A.
AU - Connor, Eileen M.
T1 - Community-oriented Primary Care: An Examination of the US Experience.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/03//
VL - 76
IS - 3
M3 - Article
SP - 279
EP - 281
PB - American Public Health Association
SN - 00900036
AB - Abstract: Community-oriented primary care (COPC) represents a specific variation on the general primary care model. Seven case studies from vastly different health care settings were examined and this report describes the diversity of expression of the principles of COPC observed. The results suggest that COPC is not limited to publicly funded programs, but can find expression in the private sector as well. The organization of financing and the lack of feasible quantitative tools hinder the full development of the model. (Am J Public Health 1986; 76:279-281.) INSET: Expanded Nurse Training Program Includes Home Health Care. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Primary health care
KW - Community health services -- Finance
KW - Health promotion
KW - Health care intervention (Social services)
KW - Medical care
KW - Medical cooperation
KW - Primary care (Medicine)
KW - Public health -- United States
KW - United States
N1 - Accession Number: 4729011; Nutting, Paul A. 1; Connor, Eileen M. 2; Affiliations: 1: Director, Office of Primary Care Studies, Health Resources and Services Administration, Room 1325, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; 2: Professional Associate, Institute of Medicine; Issue Info: Mar86, Vol. 76 Issue 3, p279; Subject Term: Primary health care; Subject Term: Community health services -- Finance; Subject Term: Health promotion; Subject Term: Health care intervention (Social services); Subject Term: Medical care; Subject Term: Medical cooperation; Subject Term: Primary care (Medicine); Subject Term: Public health -- United States; Subject: United States; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Williams, Rorert
T1 - Prevalence of Hepatitis A Virus Antibody among Navajo School Children.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/03//
VL - 76
IS - 3
M3 - Article
SP - 282
EP - 283
PB - American Public Health Association
SN - 00900036
AB - Abstract: Previous studies of the prevalence of immunity to hepatitis A (anti-HAV) in the United States have used urban settings or institutions for the mentally handicapped. In a rural setting among normal children, a serologic investigation of prevalence of anti-HAV was conducted in a boarding school adjacent to the Navajo reservation. The results show rates of anti-HAV that are the highest reported at the ages tested in any subpopulation in the United States, comparable only with those in developing countries. (Am J Public Health 1986; 76:282-283.) INSET: Irradiated What?. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunity
KW - HEALTH
KW - Enteroviruses
KW - Public health
KW - Hepatitis A virus
KW - Navajo children
KW - Diagnostic microbiology
KW - School children
KW - Children -- New Southwest (U.S.)
KW - United States
N1 - Accession Number: 4729057; Williams, Rorert 1; Affiliations: 1: Indian Health Service, PHS Indian Hospital, CrownPoint NM 87313; Issue Info: Mar86, Vol. 76 Issue 3, p282; Thesaurus Term: Immunity; Thesaurus Term: HEALTH; Thesaurus Term: Enteroviruses; Thesaurus Term: Public health; Subject Term: Hepatitis A virus; Subject Term: Navajo children; Subject Term: Diagnostic microbiology; Subject Term: School children; Subject Term: Children -- New Southwest (U.S.); Subject: United States; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bernzweig, Eli
T1 - How an emergency can spell trouble.
JO - RN
JF - RN
Y1 - 1986/03//
VL - 49
IS - 3
M3 - Article
SP - 57
EP - 58
SN - 00337021
AB - Discusses legal cases concerning the accountability of nurses during emergencies. Background of the cases; Court decisions on the cases; Implications of the cases.
KW - ACTIONS & defenses (Administrative law)
KW - EMERGENCY nursing
N1 - Accession Number: 4933491; Bernzweig, Eli 1; Source Information: Mar86, Vol. 49 Issue 3, p57; Subject: ACTIONS & defenses (Administrative law); Subject: EMERGENCY nursing; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 846
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Forbes, Allan L.
T1 - Dimensions of the issue of explicit health claims on food labels.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1986/04//
VL - 43
IS - 4
M3 - Article
SP - 629
EP - 635
SN - 00029165
AB - The article focuses on the issue of explicit health claims on food labels. The explicit health claims on food labels is important as the food label since the advent of nutrition labeling and other types of nutrition-related statements on food labels over the past 15 years. is required to maintain the accuracy of information and the integrity of the food label generally.
KW - Food labeling
KW - Physiology
KW - Food -- Shelf-life dating
KW - Well-being
KW - Health behavior
N1 - Accession Number: 91096108; Forbes, Allan L. 1; Affiliations: 1: Office of Nutrition and Food Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Apr1986, Vol. 43 Issue 4, p629; Thesaurus Term: Food labeling; Thesaurus Term: Physiology; Subject Term: Food -- Shelf-life dating; Subject Term: Well-being; Subject Term: Health behavior; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Coulehan, John L.
AU - Lerner, Guy
AU - Helzlsouer, Kathy
AU - Welty, Thomas K.
AU - McLaughlin, James
T1 - Acute Myocardial Infarction among Navajo Indians, 1976-83.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/04//
VL - 76
IS - 4
M3 - Article
SP - 412
EP - 414
PB - American Public Health Association
SN - 00900036
AB - Abstract: We found that from 1976 through 1983 the incidence of acute myocardial infarction (AMI) diagnosed among Navajo Indians remained low (0.5 per 1,000 persons age 30 years or more), although the incidence in women appears to be climbing. Navajo AMI patients are more likely to be hypertensive and diabetic than age- and sex-matched patients with gallbladder disease. Twenty-four per ¢ die within one month of AMI. (Am J Public Health 1986; 76:412-414.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Public health
KW - Myocardial infarction
KW - Navajo (North American people)
KW - Patients
KW - Hypertension
KW - Diabetics
KW - Gallbladder
KW - Coronary heart disease
KW - Native Americans
N1 - Accession Number: 4686295; Coulehan, John L. 1; Lerner, Guy 1; Helzlsouer, Kathy 1; Welty, Thomas K. 2; McLaughlin, James 2; Affiliations: 1: Department of Community Medicine, M-200 Seaife Hall, University of Pittsburgh School of Medicine Pittsburgh, PA 15261.; 2: US Indian Health Service, Navajo Area.; Issue Info: Apr1986, Vol. 76 Issue 4, p412; Thesaurus Term: DISEASES; Thesaurus Term: Public health; Subject Term: Myocardial infarction; Subject Term: Navajo (North American people); Subject Term: Patients; Subject Term: Hypertension; Subject Term: Diabetics; Subject Term: Gallbladder; Subject Term: Coronary heart disease; Subject Term: Native Americans; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hurrell Jr., Joseph
T1 - ALTERNATIVE WORK SCHEDULES: SELECTING IMPLEMENTING, AND EVALUATING.
JO - Journal of Occupational Behavior
JF - Journal of Occupational Behavior
Y1 - 1986/04//
VL - 7
IS - 2
M3 - Book Review
SP - 157
EP - 158
SN - 01422774
AB - Reviews the book "Alternative Work Schedules: Selecting, Implementing and Evaluating," by S. Ronen.
KW - WORKING hours
KW - NONFICTION
KW - RONEN, S.
KW - ALTERNATIVE Work Schedules: Selecting, Implementing & Evaluating (Book)
N1 - Accession Number: 6358853; Hurrell Jr., Joseph 1; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: Apr86, Vol. 7 Issue 2, p157; Thesaurus Term: WORKING hours; Subject Term: NONFICTION; Reviews & Products: ALTERNATIVE Work Schedules: Selecting, Implementing & Evaluating (Book); People: RONEN, S.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hill, Robert H.
AU - Needham, Larry L.
AU - Liddle, John A.
T1 - The Laboratory's Role in Environmental Health Emergency Investigations.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1986/05//
VL - 24
IS - 5
M3 - Article
SP - 363
EP - 374
SN - 07313810
AB - An emergency environmental health investigation of a mass poisoning of unknown origin is a multidiscipline effort that requires the cooperation and close communication of epidemiologists, toxicologists, and chemists. The laboratory's role in this effort is important; special instruments, knowledge, and experience are needed. Our approach to such an investigation is discussed and past cases are used as illustrations. The role of the analytical chemist is presented, and the major resources needed for these investigations are described. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Clinical Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 79032472; Hill, Robert H. 1; Needham, Larry L. 1; Liddle, John A. 1; Affiliations: 1: Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, 30333; Issue Info: 1986, Vol. 24 Issue 5, p363; Number of Pages: 12p; Document Type: Article
L3 - 10.3109/15563658608992600
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ashley, David L.
AU - Needham, Larry L.
T1 - Assessment of a Scheme for Prioritizing Inorganic Toxicants by Using Signs-and-Symptoms Analysis.
JO - Journal of Toxicology -- Clinical Toxicology
JF - Journal of Toxicology -- Clinical Toxicology
Y1 - 1986/05//
VL - 24
IS - 5
M3 - Article
SP - 375
EP - 387
SN - 07313810
AB - In cases of exposure to unknown substances, analyzing environmental or biological samples for elevated levels of toxicants can be extremely complex. We assessed a method for prioritizing toxic substances according to the agreement between toxic-specific and incident-reported signs and symptoms by analyzing 25 reported case histories of exposure to inorganic toxicants. In all but one case, this analysis scheme successfully prioritized toxicants for subsequent analysis. Despite its limitations, the scheme is a substantial improvement over other available methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Clinical Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 79032475; Ashley, David L. 1; Needham, Larry L. 1; Affiliations: 1: Division of Environmental Health Laboratory Sciences Center for Environmental Health Centers for Disease Control Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, 30333; Issue Info: 1986, Vol. 24 Issue 5, p375; Number of Pages: 13p; Document Type: Article
L3 - 10.3109/15563658608992601
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McNelis, Peter J.
T1 - The Military Family: Dynamics and Treatment (Book ).
JO - Social Work
JF - Social Work
Y1 - 1986/05//May/Jun86
VL - 31
IS - 3
M3 - Book Review
SP - 228
EP - 228
PB - Oxford University Press / USA
SN - 00378046
AB - Reviews the book "The Military Family: Dynamics and Treatment," edited by Florence W. Kaslow and Richard I. Ridenour.
KW - MILITARY Family, The (Book)
KW - KASLOW, Florence W.
KW - RIDENOUR, Richard I.
KW - FAMILIES of military personnel
KW - NONFICTION
N1 - Accession Number: 5271532; McNelis, Peter J. 1; Source Information: May/Jun86, Vol. 31 Issue 3, p228; Subject: MILITARY Family, The (Book); Subject: KASLOW, Florence W.; Subject: RIDENOUR, Richard I.; Subject: FAMILIES of military personnel; Subject: NONFICTION; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Brown, Michael D.
T1 - SOUND OFF! "Why won't they let us help deliver babies?".
JO - RN
JF - RN
Y1 - 1986/07//
VL - 49
IS - 7
M3 - Article
SP - 61
EP - 62
SN - 00337021
AB - Comments on the existence of sex discrimination in the nursing profession in the U.S. Courts' ruling about male nurses working in obstetrics; Reactions of most patients to male obstetrical nurse; Major objectives of family-centered, maternal-child nursing.
KW - SEX discrimination
KW - OBSTETRICS
KW - MALE nurses
N1 - Accession Number: 4934401; Brown, Michael D. 1; Source Information: Jul86, Vol. 49 Issue 7, p61; Subject: SEX discrimination; Subject: OBSTETRICS; Subject: MALE nurses; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 773
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rabin, Jack
AU - Keefe, Kathleen
AU - Burton, Michael
T1 - Enhancing Services for Sexual-Minority Clients: A Community Mental Health Approach.
JO - Social Work
JF - Social Work
Y1 - 1986/07//Jul/Aug86
VL - 31
IS - 4
M3 - Article
SP - 294
EP - 298
PB - Oxford University Press / USA
SN - 00378046
AB - The article describes the efforts of the community mental health services to improve services for gay people in San Francisco, California. Sexual-minority clients are reluctant to reveal their homosexuality because they fear discrimination and hostility from health care providers. Indeed, those who have been open about their sexual orientation have often encountered difficulties with health practitioners. The article describes an approach used by a community mental health district to assess its current services for sexual-minority clients, develop recommendations for more appropriate staffing and staff development, and implement a plan of community outreach and professional training. The needs assessment showed that many staff members informally evaluated needs by observing how many clients from a particular ethnic, social, or age group were already using services. The needs assessment, however, revealed some prevailing staff attitudes. Generally, staff seemed reluctant to answer questions or discuss issues related to sexuality.
KW - MENTAL health
KW - GAY people
KW - HOMOSEXUALITY
KW - COMMUNITY health services
KW - HUMAN sexuality
KW - MEDICAL care
N1 - Accession Number: 5281925; Rabin, Jack 1; Keefe, Kathleen; Burton, Michael 2; Source Information: Jul/Aug86, Vol. 31 Issue 4, p294; Subject: MENTAL health; Subject: GAY people; Subject: HOMOSEXUALITY; Subject: COMMUNITY health services; Subject: HUMAN sexuality; Subject: MEDICAL care; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Bernzweig, Eli P.
T1 - Avoiding the legal pitfalls of home care.
JO - RN
JF - RN
Y1 - 1986/08//
VL - 49
IS - 8
M3 - Article
SP - 49
EP - 50
SN - 00337021
AB - Offers ways to protect a nurse from litigation when deciding a home health career. Selection of an ethical employer; Stress education; Information on how to relay information about changes in a patient's condition.
KW - HOME care services
KW - HOME health aides
KW - NURSING
N1 - Accession Number: 4930943; Bernzweig, Eli P. 1,2; Source Information: Aug86, Vol. 49 Issue 8, p49; Subject: HOME care services; Subject: HOME health aides; Subject: NURSING; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1075
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Sundin, David S.
AU - Pedersen, David H.
AU - Frazier, Todd M.
T1 - Occupational Hazard and Health Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/09//
VL - 76
IS - 9
M3 - Editorial
SP - 1083
EP - 1084
PB - American Public Health Association
SN - 00900036
AB - The author reflects on the many methodological problems encountered in the development of surveillance systems for occupational hazards and illnesses. The goal of a surveillance system must include both hazard and disease surveillance components. However, its development is usually hampered by difficulties with identifying a particular exposure agent. Moreover, the Standard Industrial Classification coding scheme used was not designed to classify industries on the basis of common exposures.
KW - Industrial safety
KW - Occupational diseases
KW - Occupational hazards
KW - Industrial hygiene
KW - Public health surveillance
KW - Security systems
KW - Employee health promotion
N1 - Accession Number: 4685530; Sundin, David S. 1; Pedersen, David H. 1; Frazier, Todd M. 1; Affiliations: 1: National Institute for Occupational Safety and Health.; Issue Info: Sep86, Vol. 76 Issue 9, p1083; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational diseases; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial hygiene; Subject Term: Public health surveillance; Subject Term: Security systems; Subject Term: Employee health promotion; NAICS/Industry Codes: 561621 Security Systems Services (except Locksmiths); Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murphy, Lawrence R.
AU - DuBois, David
AU - Hurreu, Joseph J.
T1 - ACCIDENT REDUCTION THROUGH STRESS MANAGEMENT.
JO - Journal of Business & Psychology
JF - Journal of Business & Psychology
Y1 - 1986///Fall1986
VL - 1
IS - 1
M3 - Article
SP - 5
EP - 18
SN - 08893268
AB - The deleterious effects of occupational stress on worker health and well-being have been described in numerous reports for a wide range of work groups. Work overload (and underload), deadline pressures, role stressors, underutilization of abilities, and physical discomfort have been identified as work factors associated with increased stress symptom reporting. The relationship between work stress and accident/injury occurrences is less clearly documented, although scattered reports in the literature suggest a contributory role for stress in the accident process. In this article, data linking stress to unsafe work behavior are reviewed and a model is proposed wherein accidents can arise from impaired worker capabilities (e.g., slower reaction time) brought about by stress symptom activity (e.g., anxiety). The potential usefulness of stress management training (SMT) for shortcircuiting the stress/accidents cycle by alleviating stress symptoms is discussed in light of recent empirical research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Business & Psychology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - ORGANIZATIONAL structure
KW - TEAMS in the workplace
KW - HEALTH
KW - STRESS management
KW - SYMPTOMS
KW - WORK LIFE, MANAGEMENT, AND PERFORMANCE
N1 - Accession Number: 16851938; Murphy, Lawrence R. 1; DuBois, David 2; Hurreu, Joseph J. 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH) Cincinnati, Ohio; 2: The St. Paul Insurance Companies St. Paul, Minnesota; Issue Info: Fall1986, Vol. 1 Issue 1, p5; Thesaurus Term: JOB stress; Thesaurus Term: ORGANIZATIONAL structure; Thesaurus Term: TEAMS in the workplace; Subject Term: HEALTH; Subject Term: STRESS management; Subject Term: SYMPTOMS; Author-Supplied Keyword: WORK LIFE, MANAGEMENT, AND PERFORMANCE; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Seligman, Paul J.
AU - Halperin, WiIliam E.
AU - Mullan, Robert J.
AU - Frazier, Todd M.
T1 - Occupational Lead Poisoning in Ohio: Surveillance Using Workers' Compensation Data.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/11//
VL - 76
IS - 11
M3 - Article
SP - 1299
EP - 1302
PB - American Public Health Association
SN - 00900036
AB - Abstract: To determine the utility of workers' compensation (WC) data in a system for the surveillance of occupational lead poisoning, we reviewed workers' compensation claims for lead poisoning in Ohio. For the period 1979 through 1983, 92 (81 per ¢) of the 114 claims attributed to lead met our case definition of lead poisoning. The likelihood that a company had a case of lead poisoning was strongly correlated with the number of claims against the company. Thirty companies accounted for the 92 cases; two companies accounted for 49 per ¢ of these. Inspection by the Occupational Safety and Health Administration (OSHA) occurred at 14 of these companies, all of which were cited for violations of the OSHA lead standard. Comparison of the Standard Industrial Classification (SIC) codes for the 14 companies inspected by OSHA with the 15 companies not inspected by OSHA revealed that OSHA inspected battery manufacturers, non-ferrous foundries, secondary smelters, and primary lead smelters, but not bridge painters, manufacturers of electronic components, mechanical power transmission equipment, pumps, and paints, nor a sheriff's office where firing range slugs were remelted to make new bullets. Neither the number of cases of lead poisoning at a company nor the size of a company was related to the likelihood of being inspected by OSHA. Claims for WC appear to be a useful adjunct to an occupational lead poisoning surveillance system; their usefulness should be compared to that of other systems such as laboratory reports of elevated blood lead levels in adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial toxicology
KW - Industrial safety
KW - Workers' compensation
KW - Compensation management
KW - Health services administration
KW - Health planning
KW - Industrial policy
KW - Ohio
KW - United States. Occupational Safety & Health Administration
N1 - Accession Number: 4686803; Seligman, Paul J. 1; Halperin, WiIliam E. 1; Mullan, Robert J. 1; Frazier, Todd M. 1; Affiliations: 1: Industry-Wide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Services, National Institute for Occupational Safety and Health, NIOSH R-10, 4676, Columbia Parkway, Cincinnati, OH 45226.; Issue Info: Nov86, Vol. 76 Issue 11, p1299; Thesaurus Term: Industrial toxicology; Thesaurus Term: Industrial safety; Subject Term: Workers' compensation; Subject Term: Compensation management; Subject Term: Health services administration; Subject Term: Health planning; Subject Term: Industrial policy; Subject: Ohio ; Company/Entity: United States. Occupational Safety & Health Administration; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Klimberg, Ronald
T1 - A Survey of Aspirin Use and Reye's Syndrome Awareness among Parents.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/12//
VL - 76
IS - 12
M3 - Article
SP - 1422
EP - 1424
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national telephone survey of 1,155 parents of children 19 years of age and younger solicited patterns of medication use during episodes of childhood flu and chicken pox. During the previous two years, 6 per ¢ of the parents whose children had chicken pox and 16 per ¢ of parents whose children had flu administered aspirin. Approximately 12 per ¢ of the total sample said they would give their child aspirin if their child were to get the flu or chicken pox today. About half (53 per ¢) were aware of the contraindication against aspirin use and 40 per ¢ could spontaneously recall the name Reye's Syndrome (RS). When measured by a recognition test, 84 per ¢ of the sample said they had heard of RS. People who continued to believe that aspirin was an appropriate medication were more likely to have treated older children The RS contraindication for aspirin should be emphasized for teenagers in future public informational programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Influenza
KW - Chickenpox
KW - Aspirin
KW - Reye's syndrome
KW - Analgesics
KW - Nonsteroidal anti-inflammatory agents
KW - Juvenile diseases
KW - Child care
KW - Medical care
N1 - Accession Number: 4693190; Morris, Louis A. 1; Klimberg, Ronald 1; Affiliations: 1: Food and Drug Administration, Rockville; Issue Info: Dec1986, Vol. 76 Issue 12, p1422; Thesaurus Term: Influenza; Subject Term: Chickenpox; Subject Term: Aspirin; Subject Term: Reye's syndrome; Subject Term: Analgesics; Subject Term: Nonsteroidal anti-inflammatory agents; Subject Term: Juvenile diseases; Subject Term: Child care; Subject Term: Medical care; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wolff, George L.
T1 - Body weight and cancer.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/01//
VL - 45
IS - 1
M3 - Article
SP - 168
EP - 180
SN - 00029165
AB - The article offers information on the relationship between obesity and possibility of cancer. Topics include comparison of the obese mottled yellow and lean pseudoagouti phenotypes of the single mouse genotype, anabolic effect of obesity in castrated males and susceptibility of hyperplastic alveolar nodules to neoplastic transformation than normal mammary epithelium.
KW - Neoplastic cell transformation
KW - Obesity
KW - Cancer
KW - Genotype
KW - Epithelium
N1 - Accession Number: 91095766; Wolff, George L. 1,2; Affiliations: 1: Division of Comparative Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR; 2: Departments of Biochemistry and Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR; Issue Info: Jan1987, Vol. 45 Issue 1, p168; Thesaurus Term: Neoplastic cell transformation; Subject Term: Obesity; Subject Term: Cancer; Subject Term: Genotype; Subject Term: Epithelium; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Ehrenberg, Richard L.
AU - Singal, Mitchell
T1 - Investigation of Occupational Cancer Clusters: Theory and Practice.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/01//
VL - 77
IS - 1
M3 - Article
SP - 52
EP - 56
PB - American Public Health Association
SN - 00900036
AB - Abstract: Local and federal government agencies are often asked to investigate apparent clusters of cancer in communities or workplaces. Often these investigations cannot ulitize the methods that have been developed for evaluation of disease clusters because the clusters are too small, and the populations to he studied and the periods of time to be covered are determined in an a posteriori manner. Still, government investigators are called upon to render un official opinion of the apparent clusters. Application of a theoretical approach to cluster analysis must give way to a more pragmatic approach. A review of 61 investigations of apparent clusters conducted by the National Institute for Occupational Safety and Health (NIOSH) during the period 1978-84 showed that most of the clusters contained five or fewer cases and had no plausible occupational etiology. Despite the few clusters that were identified, these investigations generally provided a service to workers and employers who were concerned about occupational cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Industrial hygiene
KW - Industrial safety
KW - Public health
KW - Cluster analysis (Statistics)
KW - Cancer
KW - Tumors
KW - United States
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 4949059; Schulte, Paul A. 1; Ehrenberg, Richard L. 1; Singal, Mitchell 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati; Issue Info: Jan1987, Vol. 77 Issue 1, p52; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Public health; Subject Term: Cluster analysis (Statistics); Subject Term: Cancer; Subject Term: Tumors; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Westler, Jean A.
T1 - Federal Health Information Clearinghouses.
JO - Journal of the American Society for Information Science
JF - Journal of the American Society for Information Science
Y1 - 1987/01//
VL - 38
IS - 1
M3 - Article
SP - 48
EP - 51
SN - 00028231
AB - This is an overview of the Federal government's support of health information clearinghouses -- why they were initiated, their purpose, problems, and impact. Federal clearinghouses emerged in the 1960s to identify, organize, and provide access to a substantive body of information. As a support service to their sponsoring agencies, and often the only source for "fugitive" information, they constantly change to meet program priorities and facilitate the flow of information to multilevel audiences. In addition, the increasing complexity and quantity of information has intensified the need for organizing resources into coherent, manageable form. As a primary source for unbiased health information, clearinghouses strive to present a balanced view of research issues and treatment modalities. They provide inexpensive access to reliable health information, especially publicly funded research and information for the public good, and play an important role in meeting the nation's health objectives. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Information Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GOVERNMENT agencies
KW - INFORMATION retrieval
KW - FEDERAL regulation
KW - MEDICAL informatics
KW - COMPUTERS in medicine
KW - MEDICAL records
N1 - Accession Number: 16764904; Westler, Jean A. 1; Affiliations: 1: Clearinghouse Coordinator, U.S. Public Health Service.; Issue Info: Jan1987, Vol. 38 Issue 1, p48; Thesaurus Term: GOVERNMENT agencies; Thesaurus Term: INFORMATION retrieval; Thesaurus Term: FEDERAL regulation; Subject Term: MEDICAL informatics; Subject Term: COMPUTERS in medicine; Subject Term: MEDICAL records; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Blanquet, R.
AU - Phelan, M.
T1 - An unusual blue mesogleal protein from the mangrove jellyfish Cassiopea xamachana.
JO - Marine Biology
JF - Marine Biology
Y1 - 1987/03//
VL - 94
IS - 3
M3 - Article
SP - 423
EP - 430
SN - 00253162
AB - The jellyfish Cassiopea xamachana often contains a blue pigment diffused within the acellular portion of its masoglea. In the bell, both the pigment and endosymbiotic zooxanthellae are concentrated immediately beneath the ex-and subumbrellar epithelia. Chromatographic and polyacrylamide gel electrophoretic techniques demonstrate that the pigment is a highly polymeric glycoprotein (mol. wt>10 daltons) comprised of two subunits with molecular weights of 34 500 and 30 300 daltons and characterized by multiple charged species. The blue native protein exhibits light absorption maxima at 620, 587, 555 and 415 nm, while SDS denatured protein is pink with a single absorption maximum at 507 nm. No prosthetic chromophore or heavy metal component was detected. The pigment is proposed to act as a light attenuator protecting the jellyfish from injurious solar irradiation while allowing photosynthetically active wavelengths to reach the zooxanthellae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Marine Biology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Jellyfishes
KW - Zooxanthella
KW - Polyacrylamide
KW - Animal pigments
KW - Glycoproteins
N1 - Accession Number: 71121890; Blanquet, R. 1; Phelan, M. 2; Affiliations: 1: Department of Biology, Georgetown University, 20057 Washington, D.C. USA; 2: Division of Virology, Center for Drugs and Biologics, Food and Drug Administration, 20205 Bethesda USA; Issue Info: 1987, Vol. 94 Issue 3, p423; Thesaurus Term: Jellyfishes; Thesaurus Term: Zooxanthella; Thesaurus Term: Polyacrylamide; Subject Term: Animal pigments; Subject Term: Glycoproteins; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF00428249
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1987-21468-001
AN - 1987-21468-001
AU - Kent, Theodore C.
T1 - 'In the beginning was the 'name' ': Comment on Terrace.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1987/03//
VL - 42
IS - 3
SP - 273
EP - 273
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1987-21468-001. Partial author list: First Author & Affiliation: Kent, Theodore C.; Fort Yuma US Public Health Service Indian Hosp, Winterhaven, CA. Release Date: 19870801. Correction Date: 20090720. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Cognitive Mediation; Language Development. Minor Descriptor: Chimpanzees; Gorillas. Classification: Cognitive & Perceptual Development (2820); Learning & Motivation (2420). Population: Animal (20). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 1. Issue Publication Date: Mar, 1987. Copyright Statement: American Psychological Association. 1987.
AB - In commenting on the article by H. S. Terrace (see record [rid]1986-11457-001[/rid]) concerning the development of naming behavior in children and primates, the present author suggests that distinctions between ape and human capacity for language may boil down to different value systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - acquisition of naming behavior
KW - children vs gorillas & chimpanzees
KW - comments on paper by H. S. Terrace
KW - 1987
KW - Cognitive Mediation
KW - Language Development
KW - Chimpanzees
KW - Gorillas
KW - 1987
DO - 10.1037/0003-066X.42.3.273.a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1987-21468-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Cammarata, F. A.;
AU - Severson, R. W.;
AU - Hiner, W. O.;
AU - Gill, A. W.;
AU - Kayatta, A. J.;
AU - \ET/;
T1 - Pharmacy practice in the United States Army
CT - Pharmacy practice in the United States Army
JO - American Journal of Hospital Pharmacy (USA)
JF - American Journal of Hospital Pharmacy (USA)
Y1 - 1987/04/01/
VL - 44
IS - Apr
SP - 755
EP - 760
SN - 00029289
AD - Dept. of the Army, Office of the Surgeon General, 5111 Leesburg Pike, Falls Church, VA 22041-3258
N1 - Accession Number: 24-09432; Language: English; References: 3; Journal Coden: AJHPA9; Section Heading: Pharmacy Practice; Institutional Pharmacy Practice; Abstract Author: Elaine K. Snow
N2 - The current status of pharmaceutical services in the United States Army Medical Department is described. The mission of the Army Medical Department is to ensure the health of the soldier during times of peace and war. The 225 Army pharmacy officers are supported by 879 Army trained pharmacy technicians and 319 civilian pharmacists employed by the Army. Army Medical Department hospital pharmacies provide inpatient and ambulatory care services as well as specialized nuclear pharmacy, oncology, investigational drug, and materials development services. Pharmacy officers assigned to the Pharmacy Branch of the U.S. Army Academy of Health Sciences conduct 17 wk technician training programs 6 times a yr and provide other pharmacy courses and continuing education programs. The U.S. Army Allergen Extract Laboratory dispenses diagnostic and immunotherapy agents by mail in response to prescriptions submitted by military allergy clinics. Pharmacy officers may be deployed with field hospitals during times of combat or for extended training exercises.
KW - Careers--United States Army--pharmacists;
KW - Pharmacists, hospital--United States Army--role;
KW - Pharmacy, institutional, hospital--United States Army--services;
KW - Radiopharmacy--specialties--U.S. Army;
KW - Pharmacy services--United States Army;
KW - United States Army--pharmacy services;
KW - Pharmacists--United States Army--role;
KW - Manpower--pharmacists--U.S. Army;
KW - Personnel, pharmacy--supportive--training, U.S. Army;
KW - Military--pharmacy services--U.S. Army;
KW - Education, pharmaceutical--personnel, pharmacy--United States Army;
KW - Ambulatory care--United States Army--pharmacists role;
KW - Hospitals--United States Army--pharmacy services;
KW - Immunotherapy--United States Army--pharmacy services;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - MILLER, HENRY I.
T1 - The Case for Qualifying "Case by Case".
JO - Science
JF - Science
Y1 - 1987/04/10/
VL - 236
IS - 4798
M3 - Article
SP - 133
EP - 133
SN - 00368075
N1 - Accession Number: 87461349; MILLER, HENRY I. 1; Affiliations: 1: Special Assistant to the Commissioner, Food and Drug Administration, Rockville, MD 20857; Issue Info: 4/10/1987, Vol. 236 Issue 4798, p133; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Koller, Loren D.
AU - Mulhern, Sally A.
AU - Frankel, Noreen C.
AU - Steven, Mark G.
AU - Williams, Jim R.
T1 - Immune dysfunction in rats fed a diet deficient in copper.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/05//
VL - 45
IS - 5
M3 - Article
SP - 997
EP - 1006
SN - 00029165
AB - Rat pups maintained on copper (Cu)-adequate (6 ppm), Cu-deficient (2 ppm) or Cu-depleted (0 ppm) diets from parturition were killed at 8-wk. Liver Cu and serum-ceruloplasmin levels confirmed that on the 0- and 2-ppm diets, a Cu-deficient state was induced. Although body weight was unaffected by the deficiency, the liver, heart, and thymus weights (% body weight) were altered. Hepatomegaly occurred in females fed 0-ppm Cu and males fed 2-ppm Cu. Heart weights increased in both sexes fed 0-ppm Cu. Thymus weights decreased in male rats fed 0-ppm Cu. Antibody titers and natural killer-cell cytotoxicity were markedly suppressed in the animals fed 0-ppm Cu. Male rats given 2-ppm Cu showed reduced antibody titer. Delayed-type hypersensitivity and pros-taglandin E2 levels were not significantly affected. These studies suggest that certain components of the immune system are Cu dependent. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Copper
KW - Native element minerals
KW - Malnutrition
KW - Nutrition disorders
KW - Copper deficiency
KW - immune dysfunction
N1 - Accession Number: 91253913; Koller, Loren D. 1; Mulhern, Sally A. 2; Frankel, Noreen C. 3; Steven, Mark G. 3; Williams, Jim R. 3; Affiliations: 1: College of Veterinary Medicine, Oregon State University, Corvallis, OR; 2: Food and Drug Administration, Washington, DC; 3: Department of Veterinary Medicine, University of Idaho, Moscow, ID; Issue Info: May1987, Vol. 45 Issue 5, p997; Thesaurus Term: Nutrition; Thesaurus Term: Copper; Thesaurus Term: Native element minerals; Subject Term: Malnutrition; Subject Term: Nutrition disorders; Author-Supplied Keyword: Copper deficiency; Author-Supplied Keyword: immune dysfunction; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rabbani, Parviz I.
AU - Prasad, Ananda S.
AU - Tsai, Rita
AU - Harland, Barbara F.
AU - Fox, M. R. Spivey
T1 - Dietary model for production of experimental zinc deficiency in man.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/06//
VL - 45
IS - 6
M3 - Article
SP - 1514
EP - 1525
SN - 00029165
AB - A semipurified diet based on soy protein was developed to induce mild zinc deficiency in five male volunteers. Each of seven daily menus provided (mean ± SD) 2248 ± 128 kcal, S6.6 ± 5.7 g protein, 261 ± 30 g carbohydrate, 110 ± 21 g fat, 8.5 ± 1.4 g fiber, and 4.8 ± 1.3 mg zinc. The analytical value for phytate:zinc molar ratio was 21 ± 9. One subject, who received five of the menus for 28 wk, lost ~200 mg body zinc and 7% weight; zinc concentration declined 25% in plasma, 30% in lymphocytes, and 55% in neutrophils. This dietary model allowed simple formulation of new menus for subjects in diverse states of health. It caused no ill effects after prolonged consumption, and all deficiency symptoms were reversed by zinc supplementation of 30 mg/d for 20 wk. With simple manipulation, this dietary model may be used safely for gradual induction of zinc and/or other micTonutrient deficiencies in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietaries
KW - Zinc deficiency diseases
KW - Lymphocytes
KW - Neutrophils
KW - Carbohydrates
KW - Dietary model
KW - textured soy protein
KW - zinc deficiency in humans
N1 - Accession Number: 91550206; Rabbani, Parviz I. 1,2; Prasad, Ananda S. 2,3; Tsai, Rita 2,3; Harland, Barbara F. 4; Fox, M. R. Spivey 4; Affiliations: 1: Department of Medicine, Veterans Administration Medical Center, Allen Park, MI; 2: Harper-Grace Hospital and Wayne State University School) of Medicine, Detroit, MI; 3: Department of Medicine, Veterans Administration Medical Center, Allen Park, Ml; 4: Division of Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Jun1987, Vol. 45 Issue 6, p1514; Subject Term: Dietaries; Subject Term: Zinc deficiency diseases; Subject Term: Lymphocytes; Subject Term: Neutrophils; Subject Term: Carbohydrates; Author-Supplied Keyword: Dietary model; Author-Supplied Keyword: textured soy protein; Author-Supplied Keyword: zinc deficiency in humans; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Graves, Edmund J.
AU - Moien, Mary
T1 - Hospitalizations for AIDS, United States, 1984-85.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/06//
VL - 77
IS - 6
M3 - Article
SP - 729
EP - 730
PB - American Public Health Association
SN - 00900036
AB - Abstract: Data from the National Hospital Discharge Survey on hospitalizations for acquired immunodeficiency syndrome (AIDS) were analyzed for 1984-85. During 1984, an estimated 10,000 discharges from short-stay hospitals had a diagnosis of AIDS. In 1985, this figure more than doubled to 23,000. Ninety-seven percent of all AIDS discharges were male and 85 per ¢ were between the ages of 25 and 44[sub +] Hospitalizations For AIDS accounted for 510,000 days of hospital care and lusted an average of 15.6 days each (Am J Public Health 1987:77:729-730.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - Hospitals -- Admission & discharge
KW - Length of stay in hospitals
KW - Hospital records -- United States
KW - Immunological deficiency syndromes -- Diagnosis
KW - Hospital administration
KW - Public hospitals
KW - Health services administration
KW - Medical research
KW - United States
N1 - Accession Number: 4951456; Graves, Edmund J. 1; Moien, Mary 1; Affiliations: 1: National Center for Health Statistics, US Department of Health and Human Services.; Issue Info: Jun87, Vol. 77 Issue 6, p729; Thesaurus Term: AIDS (Disease); Subject Term: Hospitals -- Admission & discharge; Subject Term: Length of stay in hospitals; Subject Term: Hospital records -- United States; Subject Term: Immunological deficiency syndromes -- Diagnosis; Subject Term: Hospital administration; Subject Term: Public hospitals; Subject Term: Health services administration; Subject Term: Medical research; Subject: United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Binder, Suzanne
AU - Forney, Dave
AU - Kaye, Wendy
AU - Paschal, Dan
T1 - Arsenic exposure in children living near a former copper smelter.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/07//
VL - 39
IS - 1
M3 - Article
SP - 114
EP - 121
SN - 00074861
AB - The article presents the study on arsenic exposure among children in communities close to a former copper smelter in Anaconda, Montana. The study involved two- to six-year-old children, interview with parents and analysis of urine samples. It used various study methods such as atomic absorption spectroscopy, Mann-Whitney U test and Wilcoxon signed rank test. Results indicate the importance of considering other factors in studying arsenic exposure, such as behavior.
KW - RESEARCH
KW - HEALTH
KW - Arsenic
KW - PHYSIOLOGICAL effect
KW - Wilcoxon signed-rank test
KW - Children
KW - Atomic absorption spectroscopy
KW - U-statistics
KW - Interviewing
KW - Anaconda (Mont.)
KW - Montana
N1 - Accession Number: 70788863; Binder, Suzanne 1; Forney, Dave 2; Kaye, Wendy 3; Paschal, Dan 4; Affiliations: 1: Division of Environmental Hazards and Health Effects, Center for Environmental Health, Centers for Disease Control, USA; 2: Office of Health Assessment, Agency for Toxic Substances and Disease Registry, Centers for Disease Control, USA; 3: Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, USA; 4: Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 30333 Atlanta; Issue Info: Jul1987, Vol. 39 Issue 1, p114; Thesaurus Term: RESEARCH; Thesaurus Term: HEALTH; Subject Term: Arsenic; Subject Term: PHYSIOLOGICAL effect; Subject Term: Wilcoxon signed-rank test; Subject Term: Children; Subject Term: Atomic absorption spectroscopy; Subject Term: U-statistics; Subject Term: Interviewing; Subject: Anaconda (Mont.); Subject: Montana; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF01691798
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=70788863&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - McGowan, A
T1 - DIOGENES: a database for medical regulatory information
JO - Medical Reference Services Quarterly
JF - Medical Reference Services Quarterly
Y1 - 1987///Fal
VL - 6
IS - 3
M3 - Article
SP - 17
EP - 24
SN - 02763869
AB - This paper describes the DIOGENES database available through BRS Information Technologies. The database focuses on drug and medical device regulatory information from the Food and Drug Administration. The specific strengths of DIOGENES are mentioned as well as some plans for further development of the database.
KW - DATABASES
KW - Drug information
KW - Federal government
KW - Food
N1 - Accession Number: ISTA2203349; McGowan, A 1; Affiliations: 1 : Beltsville Research Complex Library, Food and Drug Administration, Washington, DC; Source Info: Fal 1987, Vol. 6 Issue 3, p17; Note: Update Code: 2200; Subject Term: DATABASES; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Author-Supplied Keyword: Food; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 1988-26782-001
AN - 1988-26782-001
AU - Berlin, Irving N.
T1 - Effects of changing native American cultures on child development.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 1987/07//
VL - 15
IS - 3
SP - 299
EP - 306
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
N1 - Accession Number: 1988-26782-001. Partial author list: First Author & Affiliation: Berlin, Irving N.; U New Mexico, Indian Health Service, Albuquerque, US. Release Date: 19880901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; American Indians; Child Abuse; Childhood Development; Culture Change. Minor Descriptor: Child Neglect; Poverty. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Page Count: 8. Issue Publication Date: Jul, 1987.
AB - Discusses the critical developmental problems that exist for children in many American Indian reservations, including child abuse and neglect, substance abuse, depression, and nonlearning in schools. The efforts of a few American Indian communities to emphasize the teaching of traditional ways and to deal with community problems in new ways are described. These pilot efforts, which emanate from the tribe or are encouraged and helped by mental health consultants, have begun to alter the status and sense of well-being of the adults and adolescents. Some pilot projects dealing with altering the young, high-risk, adolescent woman's image and understanding of herself and with her subsequent parenting of children, with its profound effect on newborn infants and their development, are described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - culture change & consequent poverty
KW - abuse & neglect & developmental problems
KW - Native American children & adolescents
KW - implications for traditional community role modeling & prevention
KW - 1987
KW - Adolescent Development
KW - American Indians
KW - Child Abuse
KW - Childhood Development
KW - Culture Change
KW - Child Neglect
KW - Poverty
KW - 1987
DO - 10.1002/1520-6629(198707)15:3<299::AID-JCOP2290150303>3.0.CO;2-6
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1988-27313-001
AN - 1988-27313-001
AU - Topper, Martin D.
AU - Curtis, Jackie
T1 - Extended family therapy: A clinical approach to the treatment of synergistic dual anomic depression among Navajo agency-town adolescents.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 1987/07//
VL - 15
IS - 3
SP - 334
EP - 348
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
N1 - Accession Number: 1988-27313-001. Partial author list: First Author & Affiliation: Topper, Martin D.; US Public Health Service, Indian Health Ctr, Winslow, AZ, US. Release Date: 19880901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Anomie; Dysthymic Disorder; Family Therapy; Sociocultural Factors. Classification: Group & Family Therapy (3313). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 15. Issue Publication Date: Jul, 1987.
AB - Discusses a variation of dysthymic disorder that occurs among Navajo adolescents who live in agency towns on the Navajo reservation, labeling it synergistic dual anomic depression because of the unique constellation of cultural factors present in the environment of young Navajos affected by this disorder. The disorder arises from the young person's frustration at not being able to achieve economic success in the Westernized work sector or in the native subsistence sector of the reservation economy. The successful treatment of 1 patient diagnosed as suffering from this disorder is discussed. The treatment was based on the approach of Navajo medicine men toward working with the extended family. The result was a hybrid form of therapy that had a positive outcome both for the patient and the extended family. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - extended family therapy in cross cultural context
KW - synergistic dual anomic dysthymic depression
KW - Navajo adolescents in reservation towns
KW - 1987
KW - American Indians
KW - Anomie
KW - Dysthymic Disorder
KW - Family Therapy
KW - Sociocultural Factors
KW - 1987
DO - 10.1002/1520-6629(198707)15:3<334::AID-JCOP2290150306>3.0.CO;2-F
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FOX, CECIL H.
T1 - Public Health Service Revitalization.
JO - Science
JF - Science
Y1 - 1987/07/17/
VL - 237
IS - 4812
M3 - Article
SP - 235
EP - 235
SN - 00368075
N1 - Accession Number: 87436241; FOX, CECIL H. 1; Affiliations: 1: U.S. Public Health Service, Bethesda, MD 20205; Issue Info: 7/17/1987, Vol. 237 Issue 4812, p235; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Muldoon, Joann T.
AU - Wintekmeyer, Laverne A.
AU - Eure, John A.
AU - Fuortes, Lawrence
AU - Merchant, James A.
AU - van Lier, Stephanie F.
AU - Richards, Thomas B.
T1 - Occupational Disease Surveillance Data Sources, 1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/08//
VL - 77
IS - 8
M3 - Article
SP - 1006
EP - 1008
PB - American Public Health Association
SN - 00900036
AB - Abstract: Health department epidemiologists in 50 states. New York City, and the District of Columbia were surveyed in 1985 about seven potential data sources for occupational disease surveillance. Reported sources of occupational disease data were: automated workers' compensation claims (63 per ¢ of the 52 respondents): provider reports (62 per ¢): death certificates with occupation or industry (60 per ¢): cancer registries with occupational histories (3.5 per ¢): birth certificates with parent's occupation (27 per ¢): non-cancer disease registries (13 per ¢): and hospital or insurance records (8 per ¢). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Industrial hygiene
KW - Epidemiology
KW - Occupational health services
KW - Work-related injuries
KW - Workers' compensation
KW - Cancer
KW - Work environment
KW - Health promotion
KW - United States
N1 - Accession Number: 4949768; Muldoon, Joann T. 1; Wintekmeyer, Laverne A. 1; Eure, John A. 1; Fuortes, Lawrence 2; Merchant, James A. 2; van Lier, Stephanie F. 2; Richards, Thomas B. 3; Affiliations: 1: Division of Disease Preventium and Health Promotion, Iowa Department of Public Health, Lucas Building, Des Moines, IA.; 2: Department of Preventive Medicine and Environmental Health, University of Iowa; 3: Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health; Issue Info: Aug1987, Vol. 77 Issue 8, p1006; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Thesaurus Term: Epidemiology; Subject Term: Occupational health services; Subject Term: Work-related injuries; Subject Term: Workers' compensation; Subject Term: Cancer; Subject Term: Work environment; Subject Term: Health promotion; Subject: United States; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yang, G.
AU - Imagire, S.
AU - Yasaei, P.
AU - Ragelis, E.
AU - Park, D.
AU - Page, S.
AU - Carlson, R.
AU - Guire, P.
T1 - Radioimmunoassay of paralytic shellfish toxins in clams and mussels.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/08//
VL - 39
IS - 2
M3 - Article
SP - 264
EP - 271
SN - 00074861
AB - The article presents a study on paralytic shellfish toxins' radioimmunoassay in mussels and clams. The study evaluates the usefulness and validity of the immunoassay in determining paralytic shellfish poisons (PSP) using shellfish's extracts. The study uses high-performance liquid chromatographic (HPLC) method in analyzing PSP toxins, and immunoassay as screening methods for PSP toxins. Results show that the immunoassay has a potential as a screening method for the shellfish's PSP toxins.
KW - Paralytic shellfish poisoning
KW - RESEARCH
KW - Radioimmunoassay
KW - Shellfish toxins
KW - High performance liquid chromatography
KW - Mussels
N1 - Accession Number: 70788885; Yang, G. 1; Imagire, S. 1; Yasaei, P. 1; Ragelis, E. 1; Park, D. 1; Page, S. 1; Carlson, R. 2; Guire, P. 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 20204 Washington, DC; 2: Bio-Metric Systems, Inc., 55344 Eden Prairie; Issue Info: Aug1987, Vol. 39 Issue 2, p264; Thesaurus Term: Paralytic shellfish poisoning; Thesaurus Term: RESEARCH; Subject Term: Radioimmunoassay; Subject Term: Shellfish toxins; Subject Term: High performance liquid chromatography; Subject Term: Mussels; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF01689416
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boyer, G.
AU - Sullivan, J.
AU - Andersen, R.
AU - Harrison, P.
AU - Taylor, F.
T1 - Effects of nutrient limitation on toxin production and composition in the marine dinoflagellate Protogonyaulax tamarensis.
JO - Marine Biology
JF - Marine Biology
Y1 - 1987/08//
VL - 96
IS - 1
M3 - Article
SP - 123
EP - 128
SN - 00253162
AB - Toxin production was measured by high pressure liquid chromatography (HPLC) when the marine dinoflagellate Protogonyaulax tamarensis (NEPCC 255) was grown under nitrogen or phosphorus limitation. The major toxins found in P. tamarensis (255) consisted of (N21-SO)STX (11%), (N21-SO)NeoSTX (44%), and [(N21-SO)GTX plus (N21-SO)GTX] (20%). Total toxin content on a per cell basis was high for cultures in log phase (30 to 40 fmol cell) and then decreased to ca 20 fmol cell as the cultures entered stationary phase. There was a gradual decrease in the toxin content per cell during nitrogen-limited stationary phase to ca 3 fmol cell or less. Phosphorus-limited cultures showed a markedly different response than nitrogen-limited cultures. Toxin content in P-limited cells dramatically increased at the start of stationary phase, reaching levels 3 to 4 times that observed in control and nitrogen-limited cultures. These results cannot be explained by changes in the average cell volume. Eventhough dramatic effects on the total toxin concentration were observed in response to nutrient limitation (N or P), the toxin composition (on a percent basis) remained constant. This suggests that the individual toxin composition of a given isolate is a fixed genetic trait and not a transient response to changing environmental factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Marine Biology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Toxins
KW - Dinoflagellates
KW - Phosphorus
KW - Alexandrium tamarense
N1 - Accession Number: 71121998; Boyer, G. 1; Sullivan, J. 2; Andersen, R.; Harrison, P.; Taylor, F.; Affiliations: 1: Department of Oceanography, University of British Columbia, V6T 1W5 Vancouver Canada; 2: Department of Health and Human Services, Public Health Service, Food and Drug Administration, Seafood Products Research Center, 98174 Seattle USA; Issue Info: 1987, Vol. 96 Issue 1, p123; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Toxins; Thesaurus Term: Dinoflagellates; Thesaurus Term: Phosphorus; Subject Term: Alexandrium tamarense; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/BF00394845
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trowbridge, Frederick L.
AU - Marks, James S.
AU - Lopez de Romana, Guillermo
AU - Madrid, Sofia
AU - Boutton, Thomas W.
AU - Klein, Peter D.
T1 - Body composition of Peruvian children with short stature and high weight-for-height. II Implications for the interpretation for weight-for-height as an indicator of nutritional status.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/09//
VL - 46
IS - 3
M3 - Article
SP - 411
EP - 418
SN - 00029165
AB - In some child populations, low height-for-age, suggesting chronic undernutrition, may paradoxically be accompanied by relatively high weight-for-height, suggesting obesity. This growth pattern was investigated with anthropometric assessment and body composition studies using H2180 stable isotope dilution in 139 preschool-age Peruvian children. Results suggested low height-for-age (15th percentile National Center for Health Statistics [NCHSJ) and high weight-for-height (60th percentile NCHS). Skinfold thicknesses were lower whereas arm muscle areas were more similar to NCHS reference values. Total body water (as percent body weight) was greater than reference values, consistent with lower body fat. Differences in body proportions did not account adequately for the high weight-for-height. The data suggest that the high weight-for-height in these children is not obesity but is associated with lower body fat and greater lean tissue or lean tissue hydration that may reflect dietary, environmental, or genetic influences. Weight-for-height cutoffs for wasting or obesity may require different interpretations for different populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition
KW - Obesity in children
KW - Diet
KW - Muscles
KW - Adipose tissues
KW - anthropometric indicators
KW - Body composition
KW - obesity
KW - total body water
KW - wasting
KW - weight-for-height
N1 - Accession Number: 91692340; Trowbridge, Frederick L. 1; Marks, James S. 2; Lopez de Romana, Guillermo 3; Madrid, Sofia 4; Boutton, Thomas W. 5; Klein, Peter D. 6; Affiliations: 1: Division of Nutrition, Center for Health Promotion and Education, Lima Peru; 2: Centers for Disease Control, US Public Health Service, Department of Health and Human Services, Lima, Peru; 3: Instituto de Investigaciones Nutricionales, Lima, Peru; 4: US Department of Agriculture/Agricultural Research Service-Children's Nutrition Research Center, Houston, TX; 5: Department of Pediatrics, Baylor College of Medicine, Houston, TX; 6: Texas Children's Hospital, Houston, TX; Issue Info: Sep1987, Vol. 46 Issue 3, p411; Thesaurus Term: Nutrition; Subject Term: Obesity in children; Subject Term: Diet; Subject Term: Muscles; Subject Term: Adipose tissues; Author-Supplied Keyword: anthropometric indicators; Author-Supplied Keyword: Body composition; Author-Supplied Keyword: obesity; Author-Supplied Keyword: total body water; Author-Supplied Keyword: wasting; Author-Supplied Keyword: weight-for-height; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Knutsen, Alan
AU - Roodman, Stanford
AU - Gregory Evans, R.
AU - Mueller, Kathleen
AU - Webb, Karen
AU - Stehr-Green, Paul
AU - Hoffman, Richard
AU - Schramm, Wayne
T1 - Immune studies in dioxin-exposed Missouri residents: Quail run.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/09//
VL - 39
IS - 3
M3 - Article
SP - 481
EP - 489
SN - 00074861
AB - The article presents a study on the immune toxicity in humans due to chronic or acute exposure in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Quail Run Mobile Home Park in Missouri. The study involved in vivo assessment of cellular immune function and T lymphocyte subset analysis to detect TCDD exposure among participants. Results show T cell population and function disturbances in a small percentage of TCDD exposed residents.
KW - RESEARCH
KW - Tetrachlorodibenzodioxin
KW - Cellular immunity
KW - Immunotoxicology
KW - Toxicity testing -- In vivo
KW - Cell populations
KW - Cell physiology
KW - Parks -- Missouri
KW - Missouri
N1 - Accession Number: 70788916; Knutsen, Alan; Roodman, Stanford 1; Gregory Evans, R. 2; Mueller, Kathleen 3; Webb, Karen 2; Stehr-Green, Paul 4; Hoffman, Richard 4; Schramm, Wayne 5; Affiliations: 1: Department of Pathology, Pediatric Research Institute, St. Louis University Medical Center, 63104 St. Louis; 2: Department of Internal Medicine, Pediatric Research Institute, St. Louis University Medical Center, 63104 St. Louis; 3: Division of Allergy and Clinical Immunology, Pediatric Research Institute, St. Louis University Medical Center, 63104 St. Louis; 4: Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 30333 Atlanta; 5: Missouri Department of Health, 65104 Jefferson City; Issue Info: Sep1987, Vol. 39 Issue 3, p481; Thesaurus Term: RESEARCH; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Cellular immunity; Subject Term: Immunotoxicology; Subject Term: Toxicity testing -- In vivo; Subject Term: Cell populations; Subject Term: Cell physiology; Subject Term: Parks -- Missouri; Subject: Missouri; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/BF01688314
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hill, R.
AU - Todd, G.
AU - Kilbourne, E.
AU - Cline, R.
AU - McCraw, J.
AU - Orti, D.
AU - Bailey, S.
AU - Needham, L.
T1 - Gas chromatographic/mass spectrometric determination of aniline in food oils associated with the Spanish toxic oil syndrome.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/09//
VL - 39
IS - 3
M3 - Article
SP - 511
EP - 515
SN - 00074861
AB - The article presents a study on the determination of aniline in food oils linked with the Spanish Toxic Oil Syndrome (TOS).The study used 195 oil specimens and gas chromatography/mass spectrometry to investigate the presence of aniline in specific oil samples that produced sickness in specific TOS cases. Results testify that aniline is not the toxic agent in oil samples.
KW - RESEARCH
KW - MICROBIOLOGY
KW - Gas chromatography/Mass spectrometry (GC-MS)
KW - Toxicity testing
KW - Aniline
KW - Fats & oils
KW - Toxic oil syndrome
KW - Sampling (Process)
N1 - Accession Number: 70788920; Hill, R. 1; Todd, G. 1; Kilbourne, E. 1; Cline, R. 1; McCraw, J. 1; Orti, D. 1; Bailey, S. 1; Needham, L. 1; Affiliations: 1: Division of Environmental Health Laboratory Sciences and Division of Environmental Hazards and Health Effects, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, 30333 Atlanta; Issue Info: Sep1987, Vol. 39 Issue 3, p511; Thesaurus Term: RESEARCH; Thesaurus Term: MICROBIOLOGY; Thesaurus Term: Gas chromatography/Mass spectrometry (GC-MS); Thesaurus Term: Toxicity testing; Subject Term: Aniline; Subject Term: Fats & oils; Subject Term: Toxic oil syndrome; Subject Term: Sampling (Process); NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/BF01688318
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Looker, Anne C.
AU - Sempos, Christopher T.
AU - Johnson, Clifford L.
AU - Yetley, Elizabeth A.
T1 - Comparison of dietary intakes and iron status of vitamin-mineral supplement users and nonusers, aged 1-19 years.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/10//
VL - 46
IS - 4
M3 - Article
SP - 665
EP - 672
SN - 00029165
AB - Despite widespread use of supplements, few studies have been conducted to determine if supplement users have better nutritional status. Using data from the second National Health and Nutrition Examination Survey (NHANES II), mean values of five iron status indicators (hemoglobin, mean corpuscular volume, transferrin saturation, erythrocyte protoporphyrin, and serum ferritin) and dietary intakes of several nutrients and food groups were compared between regular supplement users and nonusers aged 1-19 y. Users consumed more vitamin C and fruits and vegetables than nonusers in several age-sex groups. No significant differences in mean Fe status indicator values were observed except for hemoglobin for the 3-4-y olds and serum ferritin for the 5-10-y olds. In both cases, users had higher values than nonusers. In general, Fe status was not associated with supplement use but the reason cannot be identified from this survey. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Iron
KW - Vitamins
KW - Minerals in nutrition
KW - Hemoglobin
KW - adolescence
KW - child nutrition
KW - iron status
KW - mineral supplements
KW - nutrition survey
KW - Vitamin supplements
N1 - Accession Number: 91797715; Looker, Anne C. 1,2; Sempos, Christopher T. 1,2; Johnson, Clifford L. 1,2; Yetley, Elizabeth A. 1,2; Affiliations: 1: Division of Nutrition, Food and Drug Administration, Washington, DC; 2: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville, MD; Issue Info: Oct1987, Vol. 46 Issue 4, p665; Thesaurus Term: Dietary supplements; Thesaurus Term: Iron; Subject Term: Vitamins; Subject Term: Minerals in nutrition; Subject Term: Hemoglobin; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: child nutrition; Author-Supplied Keyword: iron status; Author-Supplied Keyword: mineral supplements; Author-Supplied Keyword: nutrition survey; Author-Supplied Keyword: Vitamin supplements; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Uhler, Allen
AU - Diachenko, Gregory
T1 - Volatile halocarbon compounds in process water and processed foods.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/10//
VL - 39
IS - 4
M3 - Article
SP - 601
EP - 607
SN - 00074861
AB - The article presents a study on the presence of volatile halocarbon compounds (VHCs) in processed foods and water from 15 processing plants in the U.S. The study used headspace capillary gas chromatography to detect VHCs in water and foods. Results show that some of VHCs were found in process water and foods including chloroform, bromodichloromethane, and perchloroethylene.
KW - Halocarbons
KW - Gas chromatography
KW - Water treatment plants
KW - Bromodichloromethane
KW - Tetrachloroethylene
KW - Chloroform
KW - Processed foods
KW - United States
N1 - Accession Number: 70788932; Uhler, Allen 1; Diachenko, Gregory 2; Affiliations: 1: Division of Contaminants Chemistry, Food and Drug Administration, 20204 Washington, DC; 2: Division of Food Chemistry and Technology, Food and Drug Administration, 20204 Washington, DC; Issue Info: Oct1987, Vol. 39 Issue 4, p601; Thesaurus Term: Halocarbons; Thesaurus Term: Gas chromatography; Thesaurus Term: Water treatment plants; Thesaurus Term: Bromodichloromethane; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Chloroform; Subject Term: Processed foods; Subject: United States; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/BF01698451
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1988-09330-001
AN - 1988-09330-001
AU - Sparber, Andrew G.
T1 - The hazards of managing the emotionally handicapped.
JF - Personnel Journal
JO - Personnel Journal
JA - Pers J
Y1 - 1987/10//
VL - 66
IS - 10
SP - 91
EP - 93
CY - US
PB - A.C. Croft Inc.
SN - 0031-5745
N1 - Accession Number: 1988-09330-001. Partial author list: First Author & Affiliation: Sparber, Andrew G.; US Public Health Service, National Health Service Corps, Rockville, MD. Release Date: 19880301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Disturbances; Employee Characteristics; Management Methods. Classification: Management & Management Training (3640). Population: Human (10). Page Count: 3. Issue Publication Date: Oct, 1987.
AB - Highlights 13 pitfalls that supervisors of emotionally handicapped employees (who by the Rehabilitative Act of 1983 can compete for positions for which they are qualified) should avoid in coping with their special problems and needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - guidelines for supervision of emotionally disturbed handicapped employees
KW - managers
KW - 1987
KW - Emotional Disturbances
KW - Employee Characteristics
KW - Management Methods
KW - 1987
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1988-04284-001
AN - 1988-04284-001
AU - Koop, C. Everett
T1 - Report of the Surgeon General's Workshop on Pornography and Public Health.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 1987/10//
VL - 42
IS - 10
SP - 944
EP - 945
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
N1 - Accession Number: 1988-04284-001. PMID: 3688623 Partial author list: First Author & Affiliation: Koop, C. Everett; US Dept of Health & Human Services, US Public Health Service, Washington, DC. Release Date: 19880201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Government Policy Making; Mental Health; Pornography; Psychosexual Behavior; Sexual Attitudes. Classification: Sexual Behavior & Sexual Orientation (2980). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 1987. Copyright Statement: American Psychological Association. 1987.
AB - A panel of clinicians and researchers concluded that pornography does stimulate attitudes and behavior that lead to gravely negative consequences for individuals and for society, and that these outcomes impair the mental, emotional, and physical health of children and adults. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pornography
KW - attitudes & behavior & well being
KW - panel of clinicians & researchers
KW - 1987
KW - Government Policy Making
KW - Mental Health
KW - Pornography
KW - Psychosexual Behavior
KW - Sexual Attitudes
KW - 1987
DO - 10.1037/0003-066X.42.10.944
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1988-04284-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Dibley, Michael J.
AU - Goldsby, James B.
AU - Staehling, Norman W.
AU - Trowbridge, Frederick L.
T1 - Development of normalized curves for the international growth reference: historical and technical considerations.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/11//
VL - 46
IS - 5
M3 - Article
SP - 736
EP - 748
SN - 00029165
AB - The World Health Organization recommended in 1978 that the National Center for Health Statistics/Centers for Disease Control growth reference curves be used as an international growth reference. To permit the expression of growth in terms of standard deviations, CDC developed growth curves from the observed data that approximate normal distributions. Because of significant skewness, standard deviations for weight-for-age and weight-for-height were calculated separately for distributions below and above the median. Standard deviations below the median were calculated from the 5th, 10th, 25th, and 50th observed percentiles while those above the median were based on the 50th, 75th, 90th, and 95th observed percentiles. Height-for-age distributions did not show significant skewness, thus, the standard deviations were calculated based on all six of the above observed percentiles. The normalized reference curves provide a highly useful data base that permits the standardized comparison of anthro-pometric data from different populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Physiology
KW - Body weight
KW - Age distribution (Demography)
KW - Age integration
KW - Anthropometry
KW - international growth reference
KW - nutritional status
KW - Z-score anthropometric indicators
KW - World Health Organization
N1 - Accession Number: 91710881; Dibley, Michael J. 1; Goldsby, James B. 1; Staehling, Norman W. 1; Trowbridge, Frederick L. 1; Affiliations: 1: Division of Nutrition, Center for Health Promotion and Education, Centers for Disease Control, US Public Health Service, Department of Health and Human Services, Atlanta, GA; Issue Info: Nov1987, Vol. 46 Issue 5, p736; Thesaurus Term: Physiology; Subject Term: Body weight; Subject Term: Age distribution (Demography); Subject Term: Age integration; Author-Supplied Keyword: Anthropometry; Author-Supplied Keyword: international growth reference; Author-Supplied Keyword: nutritional status; Author-Supplied Keyword: Z-score anthropometric indicators ; Company/Entity: World Health Organization; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Head, Susan
AU - Burse, Virlyn
T1 - Organochlorine recovery from small adipose samples with the Universal Trace Residue Extractor (Unitrex).
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1987/11//
VL - 39
IS - 5
M3 - Article
SP - 848
EP - 856
SN - 00074861
AB - The article presents a study on organochlorine recovery from small adipose tissue samples with the Universal Trace Residue Extractor (Unitrex). It states that fat extract of pesticide mixture in in-vitro spike was evaluated with the use of a method that combines deactivated alumina for lipid adsorption. Results indicate the significance of methods capable of handling certain sample sizes.
KW - Pesticides
KW - Adsorption
KW - Organochlorine compounds
KW - Adipose tissues
KW - Aluminum oxide
N1 - Accession Number: 70788968; Head, Susan 1; Burse, Virlyn 1; Affiliations: 1: Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 30333 Atlanta; Issue Info: Nov1987, Vol. 39 Issue 5, p848; Thesaurus Term: Pesticides; Thesaurus Term: Adsorption; Subject Term: Organochlorine compounds; Subject Term: Adipose tissues; Subject Term: Aluminum oxide; NAICS/Industry Codes: 327910 Abrasive Product Manufacturing; NAICS/Industry Codes: 331313 Alumina Refining and Primary Aluminum Production; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/BF01855865
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-02479-001
AN - 1989-02479-001
AU - Hamilton, Frank A.
T1 - Metoclopramide-induced akathisia.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 1987/11//
VL - 152
IS - 11
SP - 585
EP - 586
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
N1 - Accession Number: 1989-02479-001. PMID: 3122084 Partial author list: First Author & Affiliation: Hamilton, Frank A.; US Dept of Health & Human Services, US Public Health Service, Rockville, MD, US. Release Date: 19890101. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antiemetic Drugs; Drug Therapy; Gastrointestinal Disorders; Nervous System Disorders; Side Effects (Drug). Minor Descriptor: Case Report. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Clinical Case Study; Empirical Study. Page Count: 2. Issue Publication Date: Nov, 1987.
AB - Documents the side effects of metoclopramide (e.g., restlessness, fatigue, agitation, depression, extrapyramidal symptoms), commonly seen in the elderly and the very young, in a 42-yr-old man who developed akathisia 6 wks after the initiation of treatment for poorly controlled gastroesophageal reflux symptoms. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - metoclopramide induced akathisia side effects
KW - 46 yr old male with gastrointestinal reflux
KW - case report
KW - 1987
KW - Antiemetic Drugs
KW - Drug Therapy
KW - Gastrointestinal Disorders
KW - Nervous System Disorders
KW - Side Effects (Drug)
KW - Case Report
KW - 1987
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - IWAMOTO, YUKIHIDE
AU - ROBEY, FRANK A.
AU - GRAF, JEANNETTE
AU - SASAKI, MAKOTO
AU - KLEINMAN, HYNDA K.
AU - YAMADA, YOSHIHIKO
AU - MARTIN, GEORGE R.
T1 - YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimenal Metastasis Formation.
JO - Science
JF - Science
Y1 - 1987/11/20/
VL - 238
IS - 4830
M3 - Article
SP - 1132
EP - 1134
SN - 00368075
AB - The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachent and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence oflaminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477684; IWAMOTO, YUKIHIDE 1; ROBEY, FRANK A. 2; GRAF, JEANNETTE 1; SASAKI, MAKOTO 1; KLEINMAN, HYNDA K. 1; YAMADA, YOSHIHIKO 1; MARTIN, GEORGE R. 1; Affiliations: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, National Institutes of Health, Bethesda, MD 20892; 2: Bureau of Biologics, Food and Drug Administration, Bethesda, MD 20892; Issue Info: 11/20/1987, Vol. 238 Issue 4830, p1132; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mulhern, Sally A.
AU - Raveche, Elizabeth S.
AU - Smith, Howard R.
AU - Lai, Renu B.
T1 - Dietary copper deficiency and autoimmunity in the NZB mouse.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1987/12//
VL - 46
IS - 6
M3 - Article
SP - 1035
EP - 1039
SN - 00029165
AB - NZB mice were exposed from birth to a diet either adequate or deficient in copper. By age 6 wk the mice exposed to the copper-deficient diet showed symptoms characteristic of copper deficiency (anemia, hypoceruloplasminemia, and achromatrichia). The splenic lymphocytes from the copper-deficient group had reduced numbers of cells expressing the following surface markers: Ly-5, Ly-1, B-220, and sIg. Less than 10% of the splenic lymphocytes in this group were cycling, as determined by flow cytometry analysis. The spontaneous 96-h anti-ss-DNA levels in the copper-deficient group were lower than those in the control group. The exogenous colony-forming units (CFUs) were significantly enhanced in the copper-deficient mice. The decreased splenic lymphoid populations, decreased anti-ss-DNA titers, and increased exogenous CFUs in the copper-deficient mice appear to be due to an increase in erythropoiesis at the expense of lymphopoiesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Cytometry
KW - Autoimmunity
KW - Autoantibodies
KW - Lymphoid tissue
KW - copper deficiency
KW - immunology
KW - nutrition
N1 - Accession Number: 91710908; Mulhern, Sally A. 1; Raveche, Elizabeth S. 2; Smith, Howard R. 3; Lai, Renu B. 4; Affiliations: 1: Food and Drug Administration, Washington, DC; 2: Albany Medical College of Union University, Albany, NY; 3: Veterans Administration Hospital, Boston, MA; 4: National Institutes of Health, Bethesda, MD; Issue Info: Dec1987, Vol. 46 Issue 6, p1035; Thesaurus Term: Dietary supplements; Thesaurus Term: Cytometry; Subject Term: Autoimmunity; Subject Term: Autoantibodies; Subject Term: Lymphoid tissue; Author-Supplied Keyword: copper deficiency; Author-Supplied Keyword: immunology; Author-Supplied Keyword: nutrition; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Davis, Harold
AU - Honchar, Patricia A.
AU - Suarez, Lucina
T1 - Fatal Occupational Injuries of Women, Texas 1975-84.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/12//
VL - 77
IS - 12
M3 - Article
SP - 1524
EP - 1527
PB - American Public Health Association
SN - 00900036
AB - Abstract: A review of Texas death certificates for 1975-84 identified 348 cases of fatal occupational injuries of civilian females. Homicides accounted for 53 per ¢ and motor vehicle-related injuries accounted for 26 per ¢ of the deaths. Injuries from firearms caused 70 per ¢ of the homicides, One hundred thirty-three deaths occurred to women employed in the retail trade industry: of these, 77 per ¢ resulted from homicide. Women workers in gasoline service stations, food-bakery-and-dairy stores, and eating-and-drinking places had especially high risks of homicide. Texas female heavy-truck drivers had the highest fatal-injury rate, with motor-vehicle-related injuries causing 89 per ¢ of their deaths. These results indicate that effective strategies to prevent fatal occupational injuries of Texas women will need to address the problems of workplace violence and the hazards posed by motor vehicles. {Am J Public Health 1987: 77:1524-1527.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Industrial safety
KW - Occupational diseases
KW - Death (Biology)
KW - Death -- Causes -- Statistics
KW - Women employees
KW - Women
KW - Work-related injuries
KW - Mortality -- Statistics
KW - Texas
N1 - Accession Number: 4949575; Davis, Harold 1; Honchar, Patricia A. 2; Suarez, Lucina 3; Affiliations: 1: Office of Epidemiology and Biostatistics, Food and Drug Administration, 5600 Fishers Lane, HFN-733, Rockville, MD 20857; 2: National Institute for Occupational Safety and Health, CDC; 3: Bureau of Epidemiology, Texas Department of Health, Austin; Issue Info: Dec1987, Vol. 77 Issue 12, p1524; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational diseases; Thesaurus Term: Death (Biology); Subject Term: Death -- Causes -- Statistics; Subject Term: Women employees; Subject Term: Women; Subject Term: Work-related injuries; Subject Term: Mortality -- Statistics; Subject: Texas; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cohen, Lois K.
AU - Bailit, Howard L.
AU - Barmes, David E.
T1 - INTERNATIONAL COLLABORATIVE STUDY OF ORAL HEALTH OUTCOMES.
JO - International Sociology
JF - International Sociology
Y1 - 1987/12//
VL - 2
IS - 4
M3 - Article
SP - 419
EP - 426
SN - 02685809
AB - Building upon the completed WHO International Collaborative Study of Dental Manpower Systems in Relation to Oral Health Status (ICS-I), a project which extended from 1972-1983 and was operational in ten industrialised countries, the new five-year cross-national study of oral health outcomes (ICS-Il) is described. The new project includes some of the industrialised countries having participated in ICS-I plus some new ones, as well as a limited number of middle-income developing countries (Egypt, India and Uruguay).Information on the relative contribution of environmental, personal life-style and the care systems will be analysed in relation to oral health status and the costs of care. Results are expected to yield refinements in strategies for improving oral health. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Sociology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERNATIONAL cooperation
KW - DENTAL care
KW - DENTISTRY
KW - ORAL hygiene
KW - DEVELOPING countries
N1 - Accession Number: 11498808; Cohen, Lois K. 1; Bailit, Howard L. 2; Barmes, David E. 3; Affiliations: 1: Assistant Director for International Health and Chief Planning, Evaluation and Communications, National Institute of Dental Research, National Institute of Health, U.S. Public Health Service; 2: Vice-President for Health Research and Policy, Aetna Life and Casualty, Hartford, Connecticut, USA; 3: Oral Health, World Health Organization, 1211 Geneva 27, Switzerland; Issue Info: Dec87, Vol. 2 Issue 4, p419; Thesaurus Term: INTERNATIONAL cooperation; Subject Term: DENTAL care; Subject Term: DENTISTRY; Subject Term: ORAL hygiene; Subject Term: DEVELOPING countries; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Grossman, Ruth
AU - Barkdoll, Gerald
AU - Gordon, Evelyn
AU - Chun, Misoon Y.
T1 - INFORMATION SEARCH ACTIVITIES AMONG ELDERLY PRESCRIPTION DRUG USERS.
JO - Journal of Health Care Marketing
JF - Journal of Health Care Marketing
Y1 - 1987/12//
VL - 7
IS - 4
M3 - Article
SP - 5
EP - 15
PB - American Marketing Association
SN - 07373252
AB - A national telephone survey was conducted to compare prescription drug information seeking by younger and elderly patients. Though the elderly were less likely to receive counseling from health professionals, they were more likely to consult mass media sources. Path analyses indicated that collateral variables (such as patient's condition and pharmacy type) moderated information-seeking patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Care Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TELEPHONE surveys
KW - MEDICAL care
KW - DRUG monitoring
KW - HEALTH counseling
KW - DOSAGE of drugs
KW - DRUG utilization
KW - PATIENTS
KW - MEDICAL personnel & patient
KW - MEDICINE
N1 - Accession Number: 6847261; Morris, Louis A. 1; Grossman, Ruth 2; Barkdoll, Gerald 3; Gordon, Evelyn 4,5; Chun, Misoon Y. 6,7; Affiliations: 1: Psychology, Tulane University; 2: Psychology, Brooklyn College; 3: Associate Commissioner for Planning and Evaluation and a Part-Time Faculty Member, University of Southern California; 4: Sociology, American University; 5: Assistant Director for Health Programs Research, FDA's Center for Devices and Radiological Health; 6: University of California, San Francisco; 7: Pharmacist in the FDA's Division of Surgical-Dental Drug Products; Issue Info: Dec87, Vol. 7 Issue 4, p5; Thesaurus Term: TELEPHONE surveys; Thesaurus Term: MEDICAL care; Subject Term: DRUG monitoring; Subject Term: HEALTH counseling; Subject Term: DOSAGE of drugs; Subject Term: DRUG utilization; Subject Term: PATIENTS; Subject Term: MEDICAL personnel & patient; Subject Term: MEDICINE; Number of Pages: 11p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2004-20745-006
AN - 2004-20745-006
AU - Harris, Linda M.
AU - Sadeghi, Ali R.
T1 - Realizing: How Facts are Created in Human Interaction.
JF - Journal of Social and Personal Relationships
JO - Journal of Social and Personal Relationships
JA - J Soc Pers Relat
Y1 - 1987/12//
VL - 4
IS - 4
SP - 481
EP - 495
CY - US
PB - Sage Publications
SN - 0265-4075
SN - 1460-3608
AD - Harris, Linda M., 2132 Switzer Building, 330c St. SW, Washington, DC, US, 20201
N1 - Accession Number: 2004-20745-006. Partial author list: First Author & Affiliation: Harris, Linda M.; US Department of Health and Human Services, Washington, DC, US. Release Date: 20041227. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Couples Therapy; Interpersonal Interaction; Meaning. Classification: Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 1987.
AB - This paper presents a model of the construction of social reality through human interaction. Human interactants are characterized as creating (realizing) the facts they come to believe about themselves. This creative process occurs during interpersonal interactions in which both desirable and/or undesirable facts emerge. A case study of a couple in therapy demonstrates the process through which a husband and wife have created many undesirable facts between them while denying that several desirable facts happen between them. A discussion of the power and responsibility involved in realizing interpersonal experiences follows the case study analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - interpersonal interactions
KW - social reality
KW - couple therapy
KW - 1987
KW - Couples Therapy
KW - Interpersonal Interaction
KW - Meaning
KW - 1987
DO - 10.1177/0265407587044006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20745-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kinney, Janet S.
AU - Gross, Thomas P.
AU - Porter, Craig C.
AU - Rogers, Martha F.
AU - Schonberger, Lawrence B.
AU - Hurwitz, Eugene S.
T1 - Hemolytic-Uremic Syndrome: A Population-based Study in Washington, DC and Baltimore, Maryland.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/01//
VL - 78
IS - 1
M3 - Article
SP - 64
EP - 65
PB - American Public Health Association
SN - 00900036
AB - Abstract: A population-based study of hemolytic-uremic syndrome (HUS) revealed that 20 child residents of Washington, DC and Baltimore, Maryland were hospitalized with HUS from January 1979 through September 1983. The number of cases peaked during the summer and fall; none occurred during the winter. Incidence of hospitalized cases was higher in Whites and girls than in Blacks or boys, and the average annual incidence was 1.08 cases/100,000 children < 5 year old. This study demonstrates that HUS is not unique to the West Coast, as previously suggested. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Population research
KW - Hemolytic-uremic syndrome
KW - Juvenile diseases
KW - Hospital care
KW - African Americans
KW - White children
KW - Washington (D.C.)
KW - Baltimore (Md.)
KW - Maryland
N1 - Accession Number: 4686240; Kinney, Janet S. 1; Gross, Thomas P. 2; Porter, Craig C. 1; Rogers, Martha F. 3; Schonberger, Lawrence B. 3; Hurwitz, Eugene S. 3; Affiliations: 1: Department of Pediatrics, Johns Hopkins School of Medicine.; 2: Division of Epidemiology and Surveillance, Food and Drug Administration.; 3: Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control.; Issue Info: Jan1988, Vol. 78 Issue 1, p64; Thesaurus Term: DISEASES; Thesaurus Term: Population research; Subject Term: Hemolytic-uremic syndrome; Subject Term: Juvenile diseases; Subject Term: Hospital care; Subject Term: African Americans; Subject Term: White children; Subject: Washington (D.C.); Subject: Baltimore (Md.); Subject: Maryland; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Young, Frank E.
AU - Norris, John A.
T1 - Leadership Change and Action Planning: A Case Study.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1988/01//Jan/Feb88
VL - 48
IS - 1
M3 - Article
SP - 564
EP - 570
PB - Wiley-Blackwell
SN - 00333352
AB - This article describes the effective use of action planning during a period of changing leadership in the Food and Drug Administration (FDA). It describes how an action planning process ameliorated the organizational adjustments that can be expected during a major transition in the organization. The article reviews the previously observed organizational responses to change and describes the organizational setting in FDA at the time the action planning effort was undertaken. It then reviews the criteria used to design the agency's action planning process, describes the implementation and some problems encountered, and reviews lessons learned and unexpected benefits of action planning. Action planning contributed to an effective leadership transition by focusing the agency's attention on productive activities, by involving a significant portion of the agency's managers and staff in a highly visible and high priority activity, by increasing the effectiveness of communication between management and staff, and by orienting the new leadership to the agency's operations and responsibilities. The authors caution that the process must be in harmony with the organization's culture and previous experience in planning. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Administration Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLANNING
KW - GOVERNMENT agencies
KW - ORGANIZATIONAL structure
KW - MANAGEMENT
KW - EMPLOYEES
KW - COMMUNICATION
KW - BENEFIT performances
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 4599366; Young, Frank E. 1; Norris, John A. 1; Affiliations: 1: U.S. Food and Drug Administration.; Issue Info: Jan/Feb88, Vol. 48 Issue 1, p564; Thesaurus Term: PLANNING; Thesaurus Term: GOVERNMENT agencies; Thesaurus Term: ORGANIZATIONAL structure; Thesaurus Term: MANAGEMENT; Thesaurus Term: EMPLOYEES; Thesaurus Term: COMMUNICATION; Subject Term: BENEFIT performances; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - CHAP
AU - Dahlman, Carl J.
AD - US Department of Health and Human Services
A2 - Cowen, Tyler
T1 - The Problem of Externality
T2 - The theory of market failure: A critical examination
PB - Fairfax, Va.:
PB - George Mason University Press; distributed by University Publishing Associates, Lanham, Md.;
PB - Washington, D.C.:
PB - Cato Institute
Y1 - 1988///
SP - 209
EP - 234
RP - [1979]
N1 - Accession Number: 0031429; Publication Type: Collective Volume Article; Update Code: 199112
KW - Welfare Theory--Externalities 0244
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Hurrell Jr., Joseph J.
T1 - Work Stress: Health Care Systems in the Workplace.
JO - Academy of Management Executive (08963789)
JF - Academy of Management Executive (08963789)
Y1 - 1988/02//
VL - 2
IS - 1
M3 - Book Review
SP - 80
EP - 81
PB - Academy of Management
SN - 08963789
AB - This article presents a review of the book "Work Stress: Health Care Systems in the Workplace," by James C. Quick, Rabi S. Bhagat, James E. Dalton and Jonathan D. Quick.
KW - JOB stress
KW - NONFICTION
KW - QUICK, James C.
KW - BHAGAT, Rabi S.
KW - QUICK, Jonathan D.
KW - DALTON, James E.
KW - WORK Stress: Health Care Systems in the Workplace (Book)
N1 - Accession Number: 4275615; Hurrell Jr., Joseph J. 1; Affiliations: 1: National Institute for Occupational Safety and Health.; Issue Info: Feb1988, Vol. 2 Issue 1, p80; Thesaurus Term: JOB stress; Subject Term: NONFICTION; Reviews & Products: WORK Stress: Health Care Systems in the Workplace (Book); People: QUICK, James C.; People: BHAGAT, Rabi S.; People: QUICK, Jonathan D.; People: DALTON, James E.; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Book Review
L3 - 10.5465/AME.1988.4275615
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Looker, Anne C.
AU - Johnson, Clifford L.
AU - Woteki, Catherine E.
AU - Yetley, Elizabeth A.
AU - Underwood, Barbara A.
T1 - Ethnic and racial differences in serum vitamin A levels of children aged 4-11 years.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/02//
VL - 47
IS - 2
M3 - Article
SP - 247
EP - 252
SN - 00029165
AB - Interpretation of differences in serum vitamin A levels observed between Hispanic and non-Hispanic children may be complicated by confounding environmental factors. Data from the Mexican-American portion of the Hispanic Health and Nutrition Examination Survey and the second National Health and Nutrition Examination Survey were used to explore these differences in 4-11-y-old Mexican Americans and non-Hispanic blacks and whites before and after accounting for vitamin-mineral supplement use and poverty status. Initial differences in mean serum vitamin A levels and prevalences < 20 µg/dL (0.70 µmol/L) or < 25 µg/dL (0.87 µmol/L) among the three ethnic or racial groups were reduced or eliminated after accounting for the two descriptive variables. These results support the hypothesis that differences in serum vitamin A levels between Mexican-American and non-Hispanic children in the United States are due more to environmental factors than to ethnicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vitamin A
KW - Body fluids
KW - Blood plasma
KW - Serum
KW - Seroconversion
KW - Ethnic groups
KW - nutrition surveys
KW - vitamin A
N1 - Accession Number: 91710534; Looker, Anne C. 1; Johnson, Clifford L. 1; Woteki, Catherine E. 1; Yetley, Elizabeth A. 2; Underwood, Barbara A. 3; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Hyattsville, MD; 2: Division of Nutrition, Food and Drug Administration, Washington, DC; 3: National Eye Institute, National Institutes of Health, Bethesda, MD; Issue Info: Feb1988, Vol. 47 Issue 2, p247; Subject Term: Vitamin A; Subject Term: Body fluids; Subject Term: Blood plasma; Subject Term: Serum; Subject Term: Seroconversion; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: nutrition surveys; Author-Supplied Keyword: vitamin A; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Forbes, Allan L.
T1 - 1987 ASCN Public Policy Forum--Federal monitoring of the nation's nutritional status.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/02//
VL - 47
IS - 2
M3 - Article
SP - 318
EP - 319
SN - 00029165
AB - The article focuses on the ideas regarding the U.S. National Nutrition Monitoring System discussed at the American Society for Clinical Nutrition's (ASCN) 1987 Public Policy Forum. It is mentioned that the National Health and Nutrition Examination Survey (NHANES) conducted by the National Center for Health Statistics (NCHS), which actually measures the nutritional status of the population, is the core of the monitoring system.
KW - Nutritional status
KW - Nutrition -- Evaluation
KW - Food habits
KW - National Nutrition Monitoring & Related Research Program (U.S.)
KW - American Society for Clinical Nutrition
N1 - Accession Number: 91710545; Forbes, Allan L. 1; Affiliations: 1: Director, Office of Nutrition and Food Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC.; Issue Info: Feb1988, Vol. 47 Issue 2, p318; Subject Term: Nutritional status; Subject Term: Nutrition -- Evaluation; Subject Term: Food habits ; Company/Entity: National Nutrition Monitoring & Related Research Program (U.S.) ; Company/Entity: American Society for Clinical Nutrition; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Woteki, Catherine E.
AU - Briefel, Ronette R.
AU - Kuczmarski, Robert
T1 - Contributions of the National Center for Health Statistics.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/02//
VL - 47
IS - 2
M3 - Article
SP - 320
EP - 328
SN - 00029165
AB - The National Center for Health Statistics conducts a broad program of record-based systems and population surveys providing information on the health and nutritional status of the US population. The record-based systems include vital statistics and health-care surveys. Population surveys include the National Health and Nutrition Examination Survey (NHANES), the National Health Interview Survey, the National Survey of Family Growth, and epidemiologic follow-back surveys. Although all of these data systems provide nutrition-related information, the NHANES collects the most directly relevant nutritional status data through interview and examination of a national probability sample of children and adults. The third NHANES is scheduled to begin in September 1988 and is designed to provide cross-sectional estimates of dietary intake and nutritional status for nutrition-monitoring purposes and to serve as the baseline for longitudinal studies of diet and health. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical care
KW - Longevity
KW - Health behavior
KW - Nutritional status
KW - health surveys
KW - National Health and Nutrition Examination Survey
KW - NHANES
KW - nutrition surveys
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 91710546; Woteki, Catherine E. 1; Briefel, Ronette R. 1; Kuczmarski, Robert 1; Affiliations: 1: Division of Health Examination Statistics, National Center for Health Statistics, Centers for Disease Control, US Department of Health and Human Services Hyattsville, MD; Issue Info: Feb1988, Vol. 47 Issue 2, p320; Subject Term: Medical care; Subject Term: Longevity; Subject Term: Health behavior; Subject Term: Nutritional status; Author-Supplied Keyword: health surveys; Author-Supplied Keyword: National Health and Nutrition Examination Survey; Author-Supplied Keyword: NHANES; Author-Supplied Keyword: nutrition surveys ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-09676-001
AN - 1989-09676-001
AU - Claymore, Betty J.
T1 - A public health approach to suicide attempts on a Sioux reservation.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1988/03//
VL - 1
IS - 3
SP - 19
EP - 24
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1989-09676-001. PMID: 3154764 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Claymore, Betty J.; Aberdeen Area Indian Health Service, SD, US. Release Date: 19890301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Attempted Suicide; Policy Making; Public Health Services; Suicide Prevention. Minor Descriptor: At Risk Populations; Medical Records; Suicide. Classification: Community & Social Services (3373). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 6. Issue Publication Date: Mar, 1988.
AB - Reports on an analysis of 72 Indian health service medical records of suicide attempts and completions over 1 yr on a Sioux Indian reservation, using a 41-item protocol. Medical records provide significant data to develop attempter profiles, identify high-risk groups, determine high-risk days and months, and identify methods of attempts and other data useful to developing focused intervention plans. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical records data on suicide attempts & completions
KW - formation of public health policy for suicide prevention
KW - Sioux Indians
KW - 1988
KW - American Indians
KW - Attempted Suicide
KW - Policy Making
KW - Public Health Services
KW - Suicide Prevention
KW - At Risk Populations
KW - Medical Records
KW - Suicide
KW - 1988
DO - 10.5820/aian.0103.1988.19
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1989-09681-001
AN - 1989-09681-001
AU - DeBruyn, Lemyra M.
AU - Hymbaugh, Karen
AU - Valdez, Norma
T1 - Helping communities address suicide and violence: The Special Initiatives Team of the Indian Health Service.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1988/03//
VL - 1
IS - 3
SP - 56
EP - 65
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1989-09681-001. PMID: 3154768 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: DeBruyn, Lemyra M.; Dept of Health & Human Services, Public Health Service Administration Indian Health Service-Mental Health Programs, Albuquerque, NM, US. Release Date: 19890301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Community Mental Health Services; Crisis Intervention Services; Domestic Violence; Violence. Minor Descriptor: Communities; Inuit. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Page Count: 10. Issue Publication Date: Mar, 1988.
AB - Describes the Special Initiatives Team of the Mental Health Programs Branch, Indian Health Services, which was formed to provide crisis and prevention consultation to American Indian and Alaska Native communities in response to violent behaviors (suicide; homicide; domestic violence; child, sexual, and elder abuse; and other forms of family and community violence). The team incorporates cultural and historical factors in assisting communities to develop programs to combat violent behaviors and encourages community-based, community-controlled efforts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Indian Health Services Special Initiatives Team
KW - family & community violence prevention & crisis intervention
KW - American Indian & Alaskan Native communities
KW - 1988
KW - American Indians
KW - Community Mental Health Services
KW - Crisis Intervention Services
KW - Domestic Violence
KW - Violence
KW - Communities
KW - Inuit
KW - 1988
DO - 10.5820/aian.0103.1988.56
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Allen, James R.
AU - Curran, James W.
T1 - Prevention of AIDS and HIV Infection: Needs and Priorities for Epidemiologic Research.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/04//
VL - 78
IS - 4
M3 - Article
SP - 381
EP - 386
PB - American Public Health Association
SN - 00900036
AB - By the end of 1987, almost 50,000 cases of acquired immunodeficiency syndrome (AIDS) will have been reported in the United States. Although the primary epidemiology of the disease has been described, much work remains to be done to complete our understanding of the dynamics of transmission and infection with the causative virus, human immunodeficiency virus (HIV). At the state and local level, the highest priorities for epidemiologic research are to understand better the precise populations at risk of prevalent and incident HIV infection, and to use this information to direct and monitor specific prevention programs that are likely to be effective for the populations at risk. These parallel efforts—sophisticated investigative epidemiologic research and applied epidemiologic and serosurveillance studies—must be expanded rapidly and continued for the forseeable future if we are to accomplish the goal of preventing further spread of HIV. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - Communicable diseases
KW - Epidemiology
KW - Communicable diseases -- Transmission
KW - HIV (Viruses)
KW - HIV infections
KW - Lentivirus diseases
KW - HTLV (Viruses)
KW - United States
N1 - Accession Number: 4687154; Allen, James R. 1; Curran, James W. 2; Affiliations: 1: Assistant Director for Medial Science, AIDS Program, Building 6 Room 177 (G22), Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Atlanta, GA 3033; 2: Director of the AIDS Program, CID/CDC Atlanta; Issue Info: Apr88, Vol. 78 Issue 4, p381; Thesaurus Term: AIDS (Disease); Thesaurus Term: Communicable diseases; Thesaurus Term: Epidemiology; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: Lentivirus diseases; Subject Term: HTLV (Viruses); Subject: United States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Henderson, L.
AU - Patterson, Donald
T1 - Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human whole blood and its association with, and extractability from, lipoproteins.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1988/04//
VL - 40
IS - 4
M3 - Article
SP - 604
EP - 611
SN - 00074861
AB - The article presents a study which determines the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for extraction in the blood. It says that blood collected in ethylenediaminetetraacetic acid from normolipemic donors was separated into two 10-milligram (mg) aliquots. It mentions that aliquot was treated with 1.21 grams/milliliter (g/ml) infranatant fraction. Results show that plasma recombined with red blood cells was recovered in the plasma fraction.
KW - Tetrachlorodibenzodioxin
KW - RESEARCH
KW - Ethylenediaminetetraacetic acid
KW - Blood
KW - Blood plasma
KW - Erythrocytes
N1 - Accession Number: 70789093; Henderson, L. 1; Patterson, Donald 1; Affiliations: 1: U.S. Department of Health and Human Services, Division of Environmental Health Laboratory Services, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, 30333 Atlanta; Issue Info: Apr1988, Vol. 40 Issue 4, p604; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: RESEARCH; Thesaurus Term: Ethylenediaminetetraacetic acid; Subject Term: Blood; Subject Term: Blood plasma; Subject Term: Erythrocytes; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF01688387
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murphy, Lawrence R.
AU - Sorenson, Susan
T1 - Employee behaviors before and after stress management.
JO - Journal of Organizational Behavior
JF - Journal of Organizational Behavior
Y1 - 1988/04//
VL - 9
IS - 2
M3 - Article
SP - 173
EP - 182
SN - 08943796
AB - A quasi-experiment was used to compare employee behaviors before and after stress management training. Organizational records on employee absenteeism, performance ratings, equipment accidents, and work injuries were obtained for highway maintenance workers who received biofeedback (BIO=21) or muscle relaxation (MR=16) training. Similar data were gathered for a comparison group of employees who did not volunteer for training (n = 80). The pre-training period (time 1) consisted of 2 1/2 years. The post-training period was divided into the year immediately after training (time 2) and the following 1/2 year (time 3). Multiple regression analyses indicated that the MR (but not BIO) group variable explained unique variance in time 2 absenteeism (p < 0.05) but not in performance ratings, equipment accidents, nor work injuries (p > 0.05). Neither group entered predictive models for any measure at time 3 (p > 0.05). The results provide limited support for relaxation training offered as a prevention activity in work settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organizational Behavior is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYEES
KW - TRAINING
KW - STRESS management
KW - BIOLOGICAL control systems
KW - MEDITATION
KW - HEALTH promotion
KW - WORK LIFE AND WORKING CONDITIONS
N1 - Accession Number: 12496846; Murphy, Lawrence R. 1; Sorenson, Susan 2; Affiliations: 1: Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio, U.S.A.; 2: Department of Epidemiology, UCLA, Los Angeles, California, U.S.A.; Issue Info: Apr88, Vol. 9 Issue 2, p173; Thesaurus Term: EMPLOYEES; Thesaurus Term: TRAINING; Subject Term: STRESS management; Subject Term: BIOLOGICAL control systems; Subject Term: MEDITATION; Subject Term: HEALTH promotion; Author-Supplied Keyword: WORK LIFE AND WORKING CONDITIONS; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1988-36747-001
AN - 1988-36747-001
AU - Martin, Jean F.
AU - Michaud, Pierre-André
T1 - AIDS education in Switzerland: Implementing strategies to reach groups with high risk behaviours, particularly youth.
T3 - AIDS
JF - Health Education Research
JO - Health Education Research
JA - Health Educ Res
Y1 - 1988/04//
VL - 3
IS - 1
SP - 105
EP - 112
CY - United Kingdom
PB - Oxford University Press
SN - 0268-1153
SN - 1465-3648
N1 - Accession Number: 1988-36747-001. Partial author list: First Author & Affiliation: Martin, Jean F.; Faculty of Medicine & Public Health Service, Lausanne, Switzerland. Release Date: 19881201. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; At Risk Populations; Health Behavior; Health Education. Minor Descriptor: Behavior Change; Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: Switzerland. Age Group: Adolescence (13-17 yrs) (200). Page Count: 8. Issue Publication Date: Apr, 1988.
AB - Describes the implementation of federal acquired immune deficiency syndrome (AIDS) care and prevention policies in the Swiss Canton of Vaud. Efforts among 16–19 yr olds and groups at risk for AIDS, such as homosexuals and iv drug-users, to translate AIDS prevention messages into behavioral changes are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - federal AIDS education & prevention program
KW - health behavior
KW - 16–19 yr olds & high risk groups
KW - Switzerland
KW - 1988
KW - AIDS
KW - At Risk Populations
KW - Health Behavior
KW - Health Education
KW - Behavior Change
KW - Prevention
KW - 1988
DO - 10.1093/her/3.1.105
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Placek, Paul J.
AU - Taffel, Selma M.
T1 - Vaginal Birth after Cesarean (VBAC) in the 1980s.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 512
EP - 515
PB - American Public Health Association
SN - 00900036
AB - The incidence of vaginal birth after cesarean (VBAC) and characteristics of VBAC births are investigated using 1980-85 National Hospital Discharge Survey Data collected by the National Center for Health Statistics. Only 3.4 per cent of mothers with previous cesarean delivery had VBAC in their subsequent 1980 delivery; this increased to 6.6 per cent in 1985. Because VBAC is a relatively infrequent event, 1980-85 data were combined and indicate that in this period 4.9 per cent of mothers with previous cesarean had a vaginal birth in their subsequent delivery. Combined 1980-85 VBAC rates are under 10 per cent for all age, race, marital status, region, hospital size, hospital ownership, and expected source of payment groups. Between 1980 and 1985, over 1.4 million repeat cesareans were performed for mothers having a live birth. Evidence suggests that potentially over 500,000 of these repeat cesareans could have been VBACs (over and above the 74,000 VBACs which occurred). VBAC mothers' mean length of hospital stay is 3.2 days, which compares closely with 3.0 days for other vaginal deliveries, but both contrast sharply with 5.6 days for repeat cesareans and 6.0 days for primary cesareans. Except for the uterine scar from the previous cesarean, VBAC mothers appear to have about the same history and frequency of complications as mothers with other vaginal deliveries. If the 500,000 repeat cesareans had been VBACs, surgical fees and costs for 1.2 million days of hospital stay would have been averted over the 1980-85 period. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaginal birth after cesarean
KW - Cesarean section -- Prevention
KW - Delivery (Obstetrics)
KW - Childbirth
KW - Medical care costs
KW - Length of stay in hospitals
KW - Medical statistics
KW - United States
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 4686890; Placek, Paul J. 1; Taffel, Selma M. 1; Affiliations: 1: National Center for health Statistics, US Department of Health and Human Services.; Issue Info: May88, Vol. 78 Issue 5, p512; Subject Term: Vaginal birth after cesarean; Subject Term: Cesarean section -- Prevention; Subject Term: Delivery (Obstetrics); Subject Term: Childbirth; Subject Term: Medical care costs; Subject Term: Length of stay in hospitals; Subject Term: Medical statistics; Subject: United States ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Placek, Paul J.
AU - Taffel, Selma M.
AU - Moien, Mary
T1 - 1986 C-Sections Rise: VBACs Inch Upward.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 562
EP - 563
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the statistics of cesarean delivery in the U.S. in 1965 to 1986. During 1965, the rate of cesarean delivery was 4.5%, 22.7% in 1985, and has finally reached 24.1% in 1986. Such data is fairly uniform for women of all ages and marital statuses, and has been observed in hospitals of all sizes and types of ownership. The National Center for Health Statistics conducted the National Hospital Discharge Survey to monitor the annual trends of cesareans. Information came from about 200,000 medical records for inpatient discharges from a representative national sample of over 400 non-federal general and special short-stay hospitals. It also showed that almost one-fifth of teenage deliveries were cesareans.
KW - Cesarean section
KW - Delivery (Obstetrics)
KW - Obstetrics -- Surgery
KW - Marital status
KW - Medical records
KW - Public hospitals
KW - Medical statistics
KW - United States
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 4687133; Placek, Paul J. 1; Taffel, Selma M. 1; Moien, Mary 1; Affiliations: 1: National Center for Health Statistics, US Department of Health and Human Services.; Issue Info: May88, Vol. 78 Issue 5, p562; Subject Term: Cesarean section; Subject Term: Delivery (Obstetrics); Subject Term: Obstetrics -- Surgery; Subject Term: Marital status; Subject Term: Medical records; Subject Term: Public hospitals; Subject Term: Medical statistics; Subject: United States ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-02742-001
AN - 1989-02742-001
AU - Leukefeld, Carl G.
T1 - AIDS counseling and testing.
JF - Health & Social Work
JO - Health & Social Work
JA - Health Soc Work
Y1 - 1988///Sum 1988
VL - 13
IS - 3
SP - 167
EP - 169
CY - United Kingdom
PB - Oxford University Press
SN - 0360-7283
N1 - Accession Number: 1989-02742-001. PMID: 3215592 Partial author list: First Author & Affiliation: Leukefeld, Carl G.; US Public Health Service, National Inst on Drug Abuse, Rockville, MD, US. Release Date: 19890101. Correction Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; At Risk Populations; Screening Tests; Social Casework. Minor Descriptor: Counseling; Health Education. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 3. Issue Publication Date: Sum 1988.
AB - Discusses counseling for the provision of information and support related to human immunodeficiency virus (HIV) antibody testing. The process of pretest counseling and the qualifications for posttest counseling are described. It is concluded that social workers should take an active role in HIV counseling, particularly in supplying acquired immune deficiency syndrome (AIDS) information. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - role in HIV antibody pretest & postest counseling & provision of AIDS information
KW - social workers
KW - 1988
KW - AIDS
KW - At Risk Populations
KW - Screening Tests
KW - Social Casework
KW - Counseling
KW - Health Education
KW - 1988
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Wells, Victoria E.
AU - Halperin, William
AU - Thun, Michael
T1 - The Estimated Predictive Value of Screening for Illicit Drugs in the Workplace.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/07//
VL - 78
IS - 7
M3 - Article
SP - 817
EP - 819
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper estimates the predictive values of screening tests for six illicit drugs of common concern in the workplace (amphetamines, barbiturates, cocaine, hallucinogens, marijuana, and opiates) using published information on test sensitivity and specificity and survey data on prevalence. Estimated predictive values (negative) were generally high, whereas the estimated predictive value of a positive test ranged from 1 per ¢ for amphetamines to 100 per ¢ for hallucinogens and was only 38 per ¢ for marijuana, the most prevalent drug. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs of abuse
KW - Drugs
KW - Amphetamines
KW - Drug use testing
KW - Examinations
KW - Medical screening
KW - Drug abuse
KW - Barbiturates
KW - Hallucinogenic drugs
N1 - Accession Number: 4691682; Wells, Victoria E. 1; Halperin, William 1; Thun, Michael 1; Affiliations: 1: National Institute of Occupational Safety and Health; Issue Info: Jul1988, Vol. 78 Issue 7, p817; Thesaurus Term: Drugs of abuse; Thesaurus Term: Drugs; Thesaurus Term: Amphetamines; Subject Term: Drug use testing; Subject Term: Examinations; Subject Term: Medical screening; Subject Term: Drug abuse; Subject Term: Barbiturates; Subject Term: Hallucinogenic drugs; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Patriarca, Peter A.
AU - Biellik, Robin J.
AU - Sanden, Gary
AU - Burstyn, Don G.
AU - Mitchell, Paul D.
AU - Silverman, Paul R.
AU - Davis, Jeffrey P.
AU - Manclark, Charles R.
T1 - Sensitivity and Specificity of Clinical Case Definitions for Pertussis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/07//
VL - 78
IS - 7
M3 - Article
SP - 833
EP - 836
PB - American Public Health Association
SN - 00900036
AB - Abstract: We evaluated the diagnostic performance of 15 clinical case definitions for pertussis in 233 patients who developed acute respiratory illness during community outbreaks in Wisconsin and Delaware. Using results from culture (Regan-Lowe media) and serology (Ig-class-specific ELISA) as diagnostic standards, cough for >/= 14 days was both sensitive (84 per ¢-92 per ¢) and specific (63 percent-90 per ¢) m identifying patients with pertussis. This definition may be useful in monitoring pertussis outbreaks and for investigating contacts of culture-positive cases. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Diseases
KW - Respiratory diseases
KW - Whooping cough
KW - Serology
KW - Patients
KW - Respiratory organs
KW - Cardiopulmonary system
KW - Diagnostic microbiology
N1 - Accession Number: 4692589; Patriarca, Peter A. 1; Biellik, Robin J. 1; Sanden, Gary 2; Burstyn, Don G. 3; Mitchell, Paul D. 4; Silverman, Paul R. 5; Davis, Jeffrey P. 6; Manclark, Charles R. 3; Affiliations: 1: Division of Immunization, Centers for Disease Control; 2: Division of Bacterial Disease, CDC; 3: Office of Biologics Research and Review, Food and Drug Administration; 4: Marshfield, Wisconsin Clinic; 5: Delaware Department of Health; 6: Wisconsin Division of Health; Issue Info: Jul1988, Vol. 78 Issue 7, p833; Thesaurus Term: Epidemics; Thesaurus Term: Diseases; Subject Term: Respiratory diseases; Subject Term: Whooping cough; Subject Term: Serology; Subject Term: Patients; Subject Term: Respiratory organs; Subject Term: Cardiopulmonary system; Subject Term: Diagnostic microbiology; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zeeman, Maurice
T1 - CARSON CONTROVERSY CONTINUES.
JO - BioScience
JF - BioScience
Y1 - 1988/07//Jul/Aug88
VL - 38
IS - 7
M3 - Book Review
SP - 509
EP - 510
SN - 00063568
AB - Reviews the book "Silent Spring Revisited," edited by G. J. Marco, R. M. Hollingworth, and W. Durham.
KW - Pesticides & wildlife
KW - Nonfiction
KW - Silent Spring Revisited (Book)
N1 - Accession Number: 10112070; Zeeman, Maurice 1; Affiliations: 1: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; Issue Info: Jul/Aug88, Vol. 38 Issue 7, p509; Thesaurus Term: Pesticides & wildlife; Subject Term: Nonfiction; Reviews & Products: Silent Spring Revisited (Book); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 730
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Asp, Nils-Georg
AU - Furda, Ivan
AU - DeVries, Jonathan W.
AU - Schweizer, Thomas F.
AU - Prosky, Leon
AU - Englyst, Hans
AU - Cummings, John H.
T1 - Dietary fiber definition and analysis.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1988/09//
VL - 48
IS - 3
M3 - Letter to the Editor
SP - 688
EP - 691
SN - 00029165
AB - A letter to the editor and a response from the authors of the article "Dietary fiber and resistant starch" by Hans N. Englyst and colleagues in the July 1987 issue are presented.
KW - Fiber in human nutrition
KW - Starch
KW - Food -- Fiber content
N1 - Accession Number: 91711339; Asp, Nils-Georg 1; Furda, Ivan 2; DeVries, Jonathan W. 2; Schweizer, Thomas F. 3; Prosky, Leon 4; Englyst, Hans 5; Cummings, John H. 5; Affiliations: 1: University of Lund, Food Chemistry, Chemical Center, PO Box 124, S-22100 Lund, Sweden; 2: Nestec Ltd, Nestle Research Center, Vers-Chez-les-Blanc, CH-1000 Lausanne 26, Switzerland; 3: Nestec Ltd, Nestle Research Center, PO Box 353, CH-1800 Vevey, Switzerland; 4: Division of Nutrition, Food and Drug Administration, Public Health Service, 200 C Street SW, Washington, DC 20204; 5: MRC Dunn Clinical Nutrition Centre, 100 Tennis Court Road, Cambridge CB2 1QL, UK; Issue Info: Sep1988, Vol. 48 Issue 3, p688; Subject Term: Fiber in human nutrition; Subject Term: Starch; Subject Term: Food -- Fiber content; NAICS/Industry Codes: 311221 Wet Corn Milling; Number of Pages: 4p; Document Type: Letter to the Editor
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stout-Wiegand, Nancy
T1 - Fatal Occupational Injuries in US Industries, 1984: Comparison of Two National Surveillance Systems.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/09//
VL - 78
IS - 9
M3 - Article
SP - 1215
EP - 1217
PB - American Public Health Association
SN - 00900036
AB - This paper compares the results of analyses of 1984 fatalities as identified in the National Institute for Occupational Safety and Health (NIOSH) National Traumatic Occupational Fatality (NTOF) data base with those of the Bureau of Labor Statistics' Annual Survey of Occupational Injuries and Illnesses (AS) for 1984. The fatality rates for industries were similar in both analyses; however, differences in number of injuries suggest underrepresentation in the AS of fatal injuries in several, high-risk industries. Differences and similarities in methods and results between the two national surveillance systems are described and their application to research and injury prevention are discussed. (Am J Public Health 1988; 78:1215-1217.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Wounds & injuries
KW - Research
KW - Work-related injuries
KW - Accidents
KW - Industries
KW - Surveys
KW - United States
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 4686149; Stout-Wiegand, Nancy 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505; Issue Info: Sep88, Vol. 78 Issue 9, p1215; Thesaurus Term: Wounds & injuries; Thesaurus Term: Research; Subject Term: Work-related injuries; Subject Term: Accidents; Subject Term: Industries; Subject Term: Surveys; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Seligman, Paul J.
AU - Sieber Jr., William Karl
AU - Pedersen, David H.
AU - Sundin, David S.
AU - Frazier, Todd M.
T1 - Compliance with OSHA Record-keeping Requirements.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/09//
VL - 78
IS - 9
M3 - Article
SP - 1218
EP - 1219
PB - American Public Health Association
SN - 00900036
AB - The Occupational Safety and Health Act of 1970 requires employers to maintain records of workplace injuries and illnesses. To assess compliance with the law, data from the National Occupational Exposure Survey (NOES) were examined. Of the 4,185 companies with 11 or more employees, 75 per cent maintained OSHA Form 200 designed for recording illnesses and injuries. The number of employees and the presence of a union were positive determinants in the record maintenance. Of companies with 500 or more employees, 95 per cent kept records compared with 60 per cent of companies with between 11 and 99 employees. (Am J Public Health 1988, 78:1218-1219.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Wounds & injuries
KW - Diseases
KW - Work-related injuries
KW - Accidents
KW - Records management
KW - Surveys
KW - Employees
KW - Labor unions
KW - United States. Occupational Safety & Health Administration
N1 - Accession Number: 4686163; Seligman, Paul J. 1; Sieber Jr., William Karl 1; Pedersen, David H. 1; Sundin, David S. 1; Frazier, Todd M. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Sep88, Vol. 78 Issue 9, p1218; Thesaurus Term: Wounds & injuries; Thesaurus Term: Diseases; Subject Term: Work-related injuries; Subject Term: Accidents; Subject Term: Records management; Subject Term: Surveys; Subject Term: Employees; Subject Term: Labor unions ; Company/Entity: United States. Occupational Safety & Health Administration; NAICS/Industry Codes: 561490 Other business support services; NAICS/Industry Codes: 813930 Labor Unions and Similar Labor Organizations; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Lee
AU - Uhler, Allen
T1 - Volatile halocarbons in butter: Elevated tetrachloroethylene levels in samples obtained in close proximity to dry-cleaning establishments.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1988/09//
VL - 41
IS - 3
M3 - Article
SP - 469
EP - 474
SN - 00074861
AB - The article presents a study that analyzes and correlates the level of volatile hydrocarbons (VHC) and tetrachloroethylene in butter samples collected within the vicinity of dry-cleaning establishments. The study is conducted through the analysis of multiple headspace extraction (MHE) via gas chromatography. The results of the study show that perchloroethylene (PCE) is prominent as a contaminant of butter from the samples collected near the dry-cleaning establishments.
KW - RESEARCH
KW - Tetrachloroethylene
KW - Gas chromatography
KW - Butter
KW - Hydrocarbons -- Physiological effect
KW - Sampling (Process)
N1 - Accession Number: 70789190; Miller, Lee 1; Uhler, Allen 1; Affiliations: 1: Division of Contaminants Chemistry, Food and Drug Administration, 20204 Washington, DC; Issue Info: Sep1988, Vol. 41 Issue 3, p469; Thesaurus Term: RESEARCH; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Gas chromatography; Subject Term: Butter; Subject Term: Hydrocarbons -- Physiological effect; Subject Term: Sampling (Process); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 311512 Creamery Butter Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/BF01688895
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Platt, Mark W.
AU - Rottem, Shlomo
AU - Milner, Yoram
AU - Barile, Michael F.
AU - Peterkofsky, Alan
AU - Reizer, Jonathan
T1 - Protein phosphorylation in Mycoplasma gallisepticum.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/09//9/1/88
VL - 176
IS - 1
M3 - Article
SP - 62
EP - 67
SN - 00142956
AB - Incubation of the soluble fraction derived from Mycoplasma gallisepticum cells with [γ-32P]ATP results in the phosphorylation of several endogenous proteins. One protein with an apparent molecular mass of 55 kDa was the acceptor of more than 95% of the radioactive phosphate. This protein was also found to be radiolabeled in intact cells grown in the presence of [32P]orthophosphate. Acid hydrolysis of the phosphorylated 55-kDa protein followed by two-dimensional electrophoresis revealed that the 32P-labeled material co-migrated with phosphoserine. The in vitro phosphorylation of the 55-kDa protein has an optimum pH of 5.5-6.0 and is not affected by various metabolites of glycolysis, by cAMP or by calmodulin with or without Ca2+. The phosphorylation is dependent upon divalent cations, a dependency that is best fulfilled by the simultaneous addition of Ca2+ and Zn2+ that act in a specific and cooperative manner. Of a variety of possible exogenous protein acceptors tested, the endogenous protein kinase was capable to phosphorylate only phosvitin. The phosphorylation of the 55-kDa protein is reversible through the activity of a phosphoprotein phosphatase present in the soluble fraction of M. gallisepticum. The phosphoprotein phosphatase has an optimum pH of 7.5 -8.0, is inhibited by NaF and stimulated to a large extent by inorganic phosphate and arsenate and to a lesser extent by pyrophosphate ATP and ADP. The possible association of the reversible protein phosphorylation to cell shape and gliding motility of M. gallisepticum are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinases
KW - PHOSPHORYLATION
KW - HYDROGEN-ion concentration
KW - CELL morphology
KW - PHASE partition
KW - ELECTROPHORESIS
KW - CHEMICAL reactions
N1 - Accession Number: 15818680; Platt, Mark W. 1; Rottem, Shlomo 1; Milner, Yoram 2; Barile, Michael F. 3; Peterkofsky, Alan 4; Reizer, Jonathan 4; Source Information: 9/1/88, Vol. 176 Issue 1, p62; Subject: PROTEIN kinases; Subject: PHOSPHORYLATION; Subject: HYDROGEN-ion concentration; Subject: CELL morphology; Subject: PHASE partition; Subject: ELECTROPHORESIS; Subject: CHEMICAL reactions; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Horohov, D. W.
AU - Stocks, N. I.
AU - Siegel, J. P.
T1 - Limiting-dilution analysis of human CTL differentiation. Requirement for a lymphokine-mediated differentiation signal.
JO - Immunology
JF - Immunology
Y1 - 1988/09//
VL - 65
IS - 1
M3 - Article
SP - 119
EP - 124
SN - 00192805
AB - The induction of human influenza virus-specific memory cytotoxic T lymphocytes (CTL) from CTL precursors (CTLp) was investigated using limiting-dilution cultures and cell lines. Differentiation of maximal numbers of CTLp in limiting-dilution cultures required at least three signals: antigen stimulation, interleukin-2 (IL-2), and a differentiation factor distinct from IL-2. Antigen-specific CTLp proliferated in response to antigen stimulation and recombinant DNA-derived IL-2, but often failed to acquire cytolytic activity unless conditioned medium (CM) from mitogen-stimulated peripheral blood mononuclear cell (PBMC) cultures was added to the cultures. Temporal analysis of the requirement for CM indicated that it was providing a late signal for CTLp differentiation. This analysis was confirmed by developing CTLp cell lines, which were found to proliferate in response to IL-2 and antigen but not to exhibit influenza virus-specific cytotoxicity until CM was added. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - T cells
KW - ANTINEOPLASTIC antibiotics
KW - CELL proliferation
KW - MITOGENS
KW - PROTEIN precursors
N1 - Accession Number: 14004475; Horohov, D. W. 1; Stocks, N. I. 2; Siegel, J. P. 2; Source Information: Sep88, Vol. 65 Issue 1, p119; Subject: INFLUENZA; Subject: T cells; Subject: ANTINEOPLASTIC antibiotics; Subject: CELL proliferation; Subject: MITOGENS; Subject: PROTEIN precursors; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Klain, Matthew
AU - Coulehan, John L.
AU - Arena, Vincent C.
AU - Janett, Robert
T1 - More Frequent Diagnosis of Acute Myocardial Infarction among Navajo Indians.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/10//
VL - 78
IS - 10
M3 - Article
SP - 1351
EP - 1352
PB - American Public Health Association
SN - 00900036
AB - Abstract: In an earlier study, we failed to confirm a clinical impression that the incidence of acute myocardial infarction (AMI) was increasing in Navajo men. Extending our data collection an additional three years, through 1986, we observed that the attack rate in men more than doubled and there was a gradual increase among women. Most Navajos who sustain AMI are hypertensive (51 per ¢), diabetic (50 per ¢) or both (31 per ¢), but few smoke cigarettes. (Am J Public Health 1988; 78:1351-1352.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Smoking
KW - Public health
KW - Myocardial infarction
KW - Navajo (North American people)
KW - Coronary heart disease
KW - Heart diseases
KW - Hypertension
KW - Heart diseases -- Diagnosis
KW - Diabetes
N1 - Accession Number: 4692035; Klain, Matthew 1; Coulehan, John L. 1; Arena, Vincent C. 1; Janett, Robert 2; Affiliations: 1: Associate Professor, Department of Community Medicine, University of Pittsburgh, M200 Scaife Hall, Pittsburgh, PA 15261; 2: US Public Health Service Hospital, Tuba City, Arizona; Issue Info: Oct88, Vol. 78 Issue 10, p1351; Thesaurus Term: Smoking; Thesaurus Term: Public health; Subject Term: Myocardial infarction; Subject Term: Navajo (North American people); Subject Term: Coronary heart disease; Subject Term: Heart diseases; Subject Term: Hypertension; Subject Term: Heart diseases -- Diagnosis; Subject Term: Diabetes; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-13027-001
AN - 1989-13027-001
AU - Ginzburg, Harold M.
T1 - HIV related diseases and the future of the delivery of psychiatric care.
T3 - Ethical treatment of patients with AIDS
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 1988/10//
VL - 18
IS - 10
SP - 563
EP - 570
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
N1 - Accession Number: 1989-13027-001. Partial author list: First Author & Affiliation: Ginzburg, Harold M.; US Public Health Service, Health Resources & Services Administration, Rockville, MD, US. Release Date: 19890401. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Health Care Delivery; Mental Health Services; Psychiatry. Minor Descriptor: Consequence. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 8. Issue Publication Date: Oct, 1988.
AB - Discusses the recommendations of the Presidential Commission and the 1988 Institute of Medicine acquired immune deficiency syndrome (AIDS) committee for psychiatrists and other mental health professionals. The magnitude of mental health consequences of AIDS, ethical and legal concerns regarding treatment, confidentiality and human immunodeficiency virus (HIV) testing, and AIDS counseling are outlined. Interventions may assist in minimizing the psychosocial morbidity associated with HIV disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health consequences of AIDS
KW - delivery of mental health & psychiatric care
KW - 1988
KW - AIDS
KW - Health Care Delivery
KW - Mental Health Services
KW - Psychiatry
KW - Consequence
KW - 1988
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hemminki, Elina
AU - Kennedy, Dianne L.
AU - Baum, Carlene
AU - McKinlay, Sonja M.
T1 - Prescribing of Noncontraceptive Estrogens and Progestins in the United States, 1974-86.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/11//
VL - 78
IS - 11
M3 - Article
SP - 1479
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper describes changes in the prescribing of noncontraceptive estrogens and progestins, using data from pharmaceutical marketing surveys. The number of estrogen prescriptions decreased from 1975 to 1980, and then increased through 1986. Progestin use has increased since 1982; concomitant use of estrogens and progestins increased over time and was common in 1986. The trends suggest that the use of estrogens, particularly the combined use of estrogens and progestins, will continue to increase. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sex hormones
KW - Progestational hormones
KW - Estrogen
KW - Medicine -- Formulae, receipts, prescriptions
KW - Contraceptives
KW - Pharmaceutical industry
KW - Progesterone
KW - Synthetic drugs
KW - United States
N1 - Accession Number: 4690877; Hemminki, Elina 1; Kennedy, Dianne L. 2; Baum, Carlene 2; McKinlay, Sonja M. 3; Affiliations: 1: Department of Public Health. University of Helsinki. Haartmanink 3, 00290 Helsinki, Finland; 2: Division of Epidemiology and Surveillance. Food and Drug Administration. 5600 Fishers Lane. Rockville. MD; 3: Principal Research Scientist , Cambridge Research Center. American Institutes for Research; Issue Info: Nov88, Vol. 78 Issue 11, p1479; Subject Term: Sex hormones; Subject Term: Progestational hormones; Subject Term: Estrogen; Subject Term: Medicine -- Formulae, receipts, prescriptions; Subject Term: Contraceptives; Subject Term: Pharmaceutical industry; Subject Term: Progesterone; Subject Term: Synthetic drugs; Subject: United States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Davis, Harold
T1 - The Accuracy of Industry Data from Death Certificates for Workplace Homicide Victims.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/12//
VL - 78
IS - 12
M3 - Article
SP - 1579
EP - 1581
PB - American Public Health Association
SN - 00900036
AB - Abstract: This study compared death certificate data on usual industry for workplace homicide victims in five urban Texas counties, with medical examiners' data on the industries where victims were working when injured. The overall positive predictive value of the death certificate data was 72 per ¢. Death certificate data on usual industry underestimated the number of victims working in high-risk industries when injured, partly because of victims whose usual industry was recorded as student, housewife, or military personnel. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Occupational hazards
KW - Work-related injuries
KW - Industrial safety education
KW - Industrial laws & legislation
KW - Work environment
KW - Industrial management
KW - Risk management in business
KW - Death certificates
KW - Texas
KW - United States
N1 - Accession Number: 4686239; Davis, Harold 1; Affiliations: 1: Office of Epidemiology and Biostatistics, HFD-733, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; Issue Info: Dec1988, Vol. 78 Issue 12, p1579; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational hazards; Subject Term: Work-related injuries; Subject Term: Industrial safety education; Subject Term: Industrial laws & legislation; Subject Term: Work environment; Subject Term: Industrial management; Subject Term: Risk management in business; Subject Term: Death certificates; Subject: Texas; Subject: United States; NAICS/Industry Codes: 611690 All other schools and instruction; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hall, Roberta L.
AU - Dexter, Don
T1 - Smokeless Tobacco Use and Attitudes toward Smokeless Tobacco among Native Americans and Other Adolescents in the Northwest.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/12//
VL - 78
IS - 12
M3 - Article
SP - 1586
EP - 1588
PB - American Public Health Association
SN - 00900036
AB - Abstract: A survey of 1,180 sixth, ninth, and eleventh graders in three school districts in the State of Washington found that 34 per ¢ of male Native Americans, 24 per ¢ of female Native Americans, 20 per ¢ of male non-natives and 4 per ¢ of female non-natives are current users of smokeless tobacco products. In all areas and groups, the best predictor of whether an adolescent is a user is the use pattern of friends. INSET: NIH Consensus Statement on Perioperative Red Cell Transfusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Smokeless tobacco
KW - Native Americans
KW - Surveys
KW - Teenagers
KW - Tobacco industry
KW - Smokeless tobacco industry
KW - School districts
KW - Women consumers
KW - United States
N1 - Accession Number: 4686364; Hall, Roberta L. 1; Dexter, Don 2; Affiliations: 1: Professor, Department of Anthropology, Oregon State University, Corvallis, OR 97331; 2: Public Health Service Indian Health Center, Warm Springs, OR 977761; Issue Info: Dec1988, Vol. 78 Issue 12, p1586; Subject Term: Smokeless tobacco; Subject Term: Native Americans; Subject Term: Surveys; Subject Term: Teenagers; Subject Term: Tobacco industry; Subject Term: Smokeless tobacco industry; Subject Term: School districts; Subject Term: Women consumers; Subject: United States; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 111910 Tobacco Farming; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kennedy, D. L.;
AU - Goetsch, R. A.;
AU - Dreis, M. W.;
T1 - NEW CHEMICAL ENTITIES: THEIR USE AND REPORTED ADVERSE REACTIONS IN 1987
CT - NEW CHEMICAL ENTITIES: THEIR USE AND REPORTED ADVERSE REACTIONS IN 1987
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1988/12/01/
VL - 23
IS - Dec
SP - P
EP - 2
AD - Division of Epidemiology and Surveillance (HFD-737), Office of Epidemiology and Biostatistics, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857
N1 - Accession Number: 26-03225; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Adverse Drug Reactions; Investigational DrugsToxicity
N2 - The monitoring of new chemical entities (NCEs) is an important component of the U.S. Food and Drug Administration's (FDA) postmarketing surveillance system. NCEs are products containing an active moiety never previously available in the U.S. These drugs are closely watched for their first three years on the market. Of particular importance are the detection of serious unexpected reactions and the discovery of serious expected reactions occurring at an increased rate. In 1987, there were 93 drugs designated as NCEs. This study quantitates the use of these drugs using available pharmaceutical marketing research data and reviews their associated ADRs reported to FDA's Spontaneous Reporting System (SRS). Of all domestic spontaneous reports received by FDA in 1987, NCEs accounted for approximately 20% of the total, 22% of serious sports and 24% of deaths. Of the 65 with measurable use, 41% were basically hospital drugs. Most of these hospital drugs are injectable antibiotics, surgical drugs or radioactive diagnostic agents. Pharmacists practicing in the hospital setting should be aware of the importance of monitoring the use of NCEs and of reporting any associated serious ADRs to the FDA.
KW - Drugs--new--postmarketing surveillance;
KW - Drugs, adverse reactions--new drugs--postmarketing surveillance;
KW - Postmarketing surveillance--new drugs--adverse reactions;
KW - ASHP meeting abstracts--postmarketing surveillance new drugs;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Tonelli, R. J.;
T1 - UNLABELED USES FOR APPROVED DRUGS\M/REGULATORY ISSUES
CT - UNLABELED USES FOR APPROVED DRUGS\M/REGULATORY ISSUES
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1988/12/01/
VL - 23
IS - Dec
SP - PIF
EP - F-3
AD - Chief, Drug Information Analysis Branch Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Room 8B-12, Rockville, MD 20857
N1 - Accession Number: 26-03517; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations
N2 - The appropriateness of prescribing approved drugs for indications not included in their official labeling is sometimes a cause of concern and confusion among practitioners. This discussion will include issues in the approving of a drug for labeled indications, including requirements under the Federal Food, Drug, and Cosmetic Act. What does this approval mean to the manufacturer, prescriber, and dispenser of the drug? The use of approved drugs for unlabeled indications will be looked at from the perspective of the Act in the practice of medicine. Requirements as to when an Investigational New Drug Application should or should not be filed for using a drug for an unlabeled indication will be outlined.
KW - Drugs--unapproved use--regulations;
KW - Regulations--unapproved use--issues;
KW - ASHP meeting abstracts--unapproved use regulations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1989-16218-001
AN - 1989-16218-001
AU - Ross, Michael W.
T1 - Components and structure of attitudes toward AIDS.
JF - Hospital & Community Psychiatry
JO - Hospital & Community Psychiatry
JA - Hosp Community Psychiatry
Y1 - 1988/12//
VL - 39
IS - 12
SP - 1306
EP - 1308
CY - US
PB - American Psychiatric Assn
SN - 0022-1597
N1 - Accession Number: 1989-16218-001. PMID: 3229755 Other Journal Title: Psychiatric Services. Partial author list: First Author & Affiliation: Ross, Michael W.; South Australia Health Commission, Public Health Service, Australia. Release Date: 19890501. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Physical Illness (Attitudes Toward). Classification: Immunological Disorders (3291). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 3. Issue Publication Date: Dec, 1988.
AB - 102 male and 118 female college students completed a questionnaire on attitudes toward acquired immune deficiency syndrome (AIDS), and 11 aspects of attitudes were identified (e.g., fear of death, homonegative or antihomosexual opinion). Data indicate distinct dimensions in Ss' attitudes toward AIDS, including homonegative opinion and attribution of responsibility for contracting AIDS, fear of death, and lack of unrealistic concerns about AIDS. Ss who knew homosexual or bisexual men were significantly less homonegative, lacked unrealistic concerns about AIDS, were more aware of the risk of nonsexual transmission, and were less socially conservative. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attitudes toward AIDS
KW - college students
KW - 1988
KW - AIDS
KW - Physical Illness (Attitudes Toward)
KW - 1988
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - McGinnis, J. Michael
AU - Nestle, Marion
T1 - The Surgeon General's report on nutrition and health: policy implications and implementation strategies.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/01//
VL - 49
IS - 1
M3 - Article
SP - 23
EP - 28
SN - 00029165
AB - The Surgeon General's Report on Nutrition and Health was developed primarily as an authoritative source of information on which to base nutrition policy decisions. It presents a comprehensive review of the evidence that links diet to chronic disease, states the consensus of the Public Health Service on the policy implications of that evidence, and recommends specific dietary changes to reduce disease risk. It identifies reduction of fat consumption as the primary dietary priority and distinguishes recommendations appropriate for the general public from those for special populations. Its consensus on the scientific basis of diet-disease relationships establishes a foundation from which to develop policies and programs to implement the report's recommendations. The federal role in implementation is necessary and desirable but not sufficient. Leadership and commitment from the state, local, private, and voluntary sectors are also essential for creation of an environment that promotes improved food choices by individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition policy -- United States
KW - Preventive medicine
KW - Diet therapy
KW - Diseases -- Risk factors
KW - Public health administration -- United States
KW - dietary recommendations
KW - Nutrition policy
KW - nutrition programs
KW - policy implementation
KW - United States. Public Health Service. Office of the Surgeon General
N1 - Accession Number: 91731587; McGinnis, J. Michael 1; Nestle, Marion 1; Affiliations: 1: Office of Disease Prevention and Health Promotion, Public Health Service, Department of Health and Human Services, Washington, DC; Issue Info: Jan1989, Vol. 49 Issue 1, p23; Subject Term: Nutrition policy -- United States; Subject Term: Preventive medicine; Subject Term: Diet therapy; Subject Term: Diseases -- Risk factors; Subject Term: Public health administration -- United States; Author-Supplied Keyword: dietary recommendations; Author-Supplied Keyword: Nutrition policy; Author-Supplied Keyword: nutrition programs; Author-Supplied Keyword: policy implementation ; Company/Entity: United States. Public Health Service. Office of the Surgeon General; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kaczmarek, Ronald G.
AU - Moore Jr., Roscoe M.
AU - Keppel, Kenneth G.
AU - Placek, Paul J.
T1 - X-Ray Examinations during Pregnancy: National Natality Surveys, 1963 and 1980.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/01//
VL - 79
IS - 1
M3 - Article
SP - 75
EP - 77
PB - American Public Health Association
SN - 00900036
AB - Based on 1963 and 1980 National Natality Surveys, the rate of medical x-ray examinations during pregnancy per 100 mothers fell 34.2 percent. A decrease in chest x-ray examinations accounted for almost all of the decline in total x-ray examinations. The reductions were greater for older mothers and those who were not White. While the number of births fell from 4,071,000 in 1963 to 3,612,000 in 1980, the number of pelvimetry examinations actually increased by 45,000. (Am J Public Health 1989; 79:75-77.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - RESEARCH
KW - X-rays
KW - Pregnancy
KW - Surveys
KW - Mothers
KW - Women
KW - Clinical medicine
KW - Clinical trials
KW - Therapeutics
KW - Medical care
N1 - Accession Number: 4685502; Kaczmarek, Ronald G. 1; Moore Jr., Roscoe M. 1; Keppel, Kenneth G. 1; Placek, Paul J. 1; Affiliations: 1: Center fro Devices and Radiological Health (CDRH) of the Food and Drug Administration; Issue Info: Jan1989, Vol. 79 Issue 1, p75; Thesaurus Term: Public health; Thesaurus Term: RESEARCH; Subject Term: X-rays; Subject Term: Pregnancy; Subject Term: Surveys; Subject Term: Mothers; Subject Term: Women; Subject Term: Clinical medicine; Subject Term: Clinical trials; Subject Term: Therapeutics; Subject Term: Medical care; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 1989-98130-004
AN - 1989-98130-004
AU - George, Frank R.
ED - Barkai, Amiram I.
ED - Bazan, Nicolas G.
ED - Barkai, Amiram I., (Ed)
ED - Bazan, Nicolas G., (Ed)
T1 - The role of arachidonic acid metabolites in mediating ethanol self-administration and intoxication.
T2 - Arachidonic acid metabolism in the nervous system: Physiological and pathological significance.
T3 - Annals of the New York Academy of Sciences; Vol 559; ISSN: 0077-8923 (Print)
Y1 - 1989///
VL - 559
SP - 382
EP - 391
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 0077-8923
SN - 0-89766-502-3
SN - 0-89766-503-1
N1 - Accession Number: 1989-98130-004. Partial author list: First Author & Affiliation: George, Frank R.; US Dept of Health & Human Services, US Public Health Service, Alcohol, Drug Abuse & Mental Health Administration, National Inst on Drug Abuse, Addiction Research Ctr, Behavior Genetics Lab, Preclinical Pharmacology Branch, Baltimore, MD, US. Release Date: 19890101. Correction Date: 20150713. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-89766-502-3, Hardcover; 0-89766-503-1, Paperback. Language: English. Major Descriptor: Ethanol; Fatty Acids; Self-Stimulation; Arachidonic Acid. Minor Descriptor: Neurochemistry; Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). Page Count: 10.
AB - prostaglandin synthesis inhibitors [PGSI] antagonize the effects of alcohols, indicating that some aspect of cylooxygenase activity and arachidonic acid metabolism is involved in the mechanism of action of alcohols establish the extent to which a group of rats would orally self-administer ethanol over a range of conditions / determine if the PGSI antagonism of acute ethanol-related behaviors can be extended to include antagonism of the reinforcing effects of ethanol / examine the specificity of this [PGSI] effect by testing the ability of PGSI treatment to decrease responding to a nonalcohol reinforcer (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Ethanol
KW - Fatty Acids
KW - Self-Stimulation
KW - Arachidonic Acid
KW - Neurochemistry
KW - Rats
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Gaylor, D W
T1 - Estimation of cancer risk
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1989///
VL - 23
IS - 2
M3 - Article
SP - 303
EP - 307
SN - 00928615
AB - In rare instances human dose-response data exist relating cancer risk to dose. Generally, cancer risk estimates must be based on the results of animal bioassays. Animals are generally dosed at levels exceeding human exposure levels to elicit potential toxic effects in relatively small numbers of animals. The problem of high- to low-dose extrapolation is discussed. In addition, extrapolation of tumor rates must be made from test animals to humans. A discussion of techniques for interspecies scaling of dose is presented. The use of pharmacokinetics and physiologically based pharmacokinetic models to replace the administered dose with an effective target tissue dose is incorporated for improved risk estimates. Finally, in most bioassays the animals are exposed to a potential carcinogen throughout their lifetime. Exposures of humans to some carcinogens may be for relatively brief periods of time. Procedures for estimating cancer risks for short-term exposures from lifetime bioassays are presented.
KW - MEDICAL informatics
KW - Cancer
KW - Healthcare
KW - Pharmacy
N1 - Accession Number: ISTA2402570; Gaylor, D W 1; Affiliations: 1 : National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR; Source Info: 1989, Vol. 23 Issue 2, p303; Note: Update Code: 2400; Subject Term: MEDICAL informatics; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Healthcare; Author-Supplied Keyword: Pharmacy; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Mazis, Michael B.
AU - Brinberg, David
T1 - Risk Disclosures in Televised Prescription Drug Advertising to Consumers.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1989/01//
VL - 8
IS - 1
M3 - Article
SP - 64
EP - 80
PB - American Marketing Association
SN - 07439156
AB - Advertising prescription drugs directly to the public is a marketing strategy currently being considered by several manufacturers. However, direct-to-consumer advertising is discouraged because federal regulations mandate extensive disclosure of product risks within television commercials. An experimental sturdy of 676 subjects was performed to examine the impact of risk disclosure variations in television commercials on awareness and knowledge of both the warnings and the promotional messages. The amount, specificity, and format of risk information contained in the ads was varied while the promotional message remained constant Results indicated a ‘trade-off’ in risk/benefit communications. Risk disclosures that produced greater risk awareness and knowledge also reduced promotional message awareness and knowledge. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Advertising
KW - Marketing
KW - Consumers
KW - Television advertising
KW - Drugs
KW - Medicine -- Formulae, receipts, prescriptions
KW - Marketing strategy
KW - Federal regulation
KW - Industrialists
KW - Disclosure
KW - Manufactures
N1 - Accession Number: 4585736; Morris, Louis A. 1,2; Mazis, Michael B. 3; Brinberg, David 4; Affiliations: 1: Center for Marketing Policy Research, American University, Washington, DC 20016; 2: Acting Director, Division of Drug Advertising, Food and Drug Administration; 3: Professor of Marketing, American University; 4: Associate Professor of Marketing, SUNY-Albany, Albany, NY 12222; Issue Info: 1989, Vol. 8 Issue 1, p64; Thesaurus Term: Advertising; Thesaurus Term: Marketing; Thesaurus Term: Consumers; Thesaurus Term: Television advertising; Subject Term: Drugs; Subject Term: Medicine -- Formulae, receipts, prescriptions; Subject Term: Marketing strategy; Subject Term: Federal regulation; Subject Term: Industrialists; Subject Term: Disclosure; Subject Term: Manufactures; NAICS/Industry Codes: 541850 Outdoor Advertising; NAICS/Industry Codes: 541890 Other Services Related to Advertising; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 339990 All other miscellaneous manufacturing; NAICS/Industry Codes: 339999 All Other Miscellaneous Manufacturing; NAICS/Industry Codes: 541613 Marketing Consulting Services; Number of Pages: 17p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - CHAP
ID - 1989-98644-007
AN - 1989-98644-007
AU - Henk, Matthew L.
ED - Henk, Matthew L.
ED - Henk, Matthew L., (Ed)
T1 - Public health role.
T2 - Social work in primary care.
T3 - Sage sourcebooks for the human services series, Vol. 8
Y1 - 1989///
SP - 113
EP - 126
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-8039-3035-6
SN - 0-8039-3036-4
N1 - Accession Number: 1989-98644-007. Partial author list: First Author & Affiliation: Henk, Matthew L.; US Public Health Service, Public Health Social Work Consultant, Kansas City, MO, US. Release Date: 19890101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8039-3035-6, Hardcover; 0-8039-3036-4, Paperback. Language: English. Major Descriptor: Health Care Services; Social Casework; Social Workers. Classification: Health Psychology & Medicine (3360). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14.
AB - describe how a public health social work practice could be developed in a primary care setting using a five-phase problem-solving process / assessment of needs / targeting interventions / prioritizing interventions / planning intervention strategies / evaluating the effectiveness of the interventions [provide] examples of the process (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Health Care Services
KW - Social Casework
KW - Social Workers
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1989-98644-008
AN - 1989-98644-008
AU - Henk, Matthew L.
ED - Henk, Matthew L.
ED - Henk, Matthew L., (Ed)
T1 - Record keeping and data collection: Critical elements for quality care.
T2 - Social work in primary care.
T3 - Sage sourcebooks for the human services series, Vol. 8
Y1 - 1989///
SP - 127
EP - 144
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-8039-3035-6
SN - 0-8039-3036-4
N1 - Accession Number: 1989-98644-008. Partial author list: First Author & Affiliation: Henk, Matthew L.; US Public Health Service, Public Health Social Work Consultant, Kansas City, MO, US. Release Date: 19890101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8039-3035-6, Hardcover; 0-8039-3036-4, Paperback. Language: English. Major Descriptor: Medical Records; Social Workers. Minor Descriptor: Health Care Services. Classification: Health Psychology & Medicine (3360). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 18.
AB - provides a review of the problem-oriented method of record keeping, describes the various data collection and tracking systems, and demonstrates how these systems could improve health care delivery the collection of data by medical diagnosis, age, sex, and geographic area will allow social workers to develop programs for at-risk population groups, accomplish research, evaluate quality of care, and document that the social work department is accomplishing its goals and objectives (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Medical Records
KW - Social Workers
KW - Health Care Services
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1989-98644-009
AN - 1989-98644-009
AU - Leukefeld, Carl G.
AU - Battjes, Robert J.
ED - Henk, Matthew L.
ED - Henk, Matthew L., (Ed)
T1 - Interprofessional collaboration.
T2 - Social work in primary care.
T3 - Sage sourcebooks for the human services series, Vol. 8
Y1 - 1989///
SP - 145
EP - 159
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-8039-3035-6
SN - 0-8039-3036-4
N1 - Accession Number: 1989-98644-009. Partial author list: First Author & Affiliation: Leukefeld, Carl G.; US Public Health Service, Chief Health Services Officer, Rockville, MD, US. Release Date: 19890101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8039-3035-6, Hardcover; 0-8039-3036-4, Paperback. Language: English. Major Descriptor: Health Care Services; Social Casework; Social Workers. Classification: Health Psychology & Medicine (3360). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 15.
AB - review social work's role in primary health care as an integral part of the health care team after considering challenges to interdisciplinary collaboration identified by the Joint Commission on Interprofessional Affairs (JCIA), the emergence of the interdisciplinary team in primary care is addressed role expectation and conflicts are briefly reviewed and examined, and factors that facilitate team development are considered (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Health Care Services
KW - Social Casework
KW - Social Workers
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1997-72077-001
AN - 1997-72077-001
AU - Stewart, Joseph L.
T1 - Speech analysis in neurogenic disorders.
JF - Indian Journal of Disability & Rehabilitation
JO - Indian Journal of Disability & Rehabilitation
Y1 - 1989/01//Jan-Jun, 1989
VL - 3
IS - 1
SP - 61
EP - 69
CY - India
PB - District Rehabilitation Centre Scheme, Ministry of Welfare, Government of India
SN - 0970-2474
N1 - Accession Number: 1997-72077-001. Partial author list: First Author & Affiliation: Stewart, Joseph L.; US Dept of Health & Human Services, Indian Health Service Sensory Disabilities Program, Albuquerque, NM, US. Release Date: 19970701. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Computer Applications; Computer Assisted Diagnosis; Parkinson's Disease; Prediction; Speech Characteristics. Minor Descriptor: Disease Course. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 9. Issue Publication Date: Jan-Jun, 1989.
AB - The overall aims of this study were to establish a speech- voice laboratory (1) to assist in the presymptomatic and/or early diagnosis of neurogenic disorders which have dysarthria as a symptom; and (2) to determine the usefulness of using these measures in predicting the course of the disorder. The specific initial aims were (1) to determine the feasibility of using newly developed computerized speech analysis equipment with other measures, to analyze specific physical characteristics of speech; (2) to develop normative data on these measures to compare with existing data obtained through procedures not amenable to rapid analysis; and (3) to compare the results of normal Ss with those of patients diagnosed with Parkinson's disease to determine which parameters best discriminate between groups. Two groups of Ss, one Experimental group with 16 Ss (aged 40–79 yrs) with Parkinson's disease, and one control group with 80 Ss (aged 40–79 yrs) participated in the study. Results in meeting these aims were positive and indicate definite direction for new research which will enable these procedures to be used clinically. The various measures most useful in each of two computerized systems and the shortcomings of each are discussed in detail. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - efficacy of computerized speech analysis
KW - early diagnosis of neurogenic disorders & prediction of disease course
KW - 40–79 yr olds with Parkinson's disease
KW - 1989
KW - Computer Applications
KW - Computer Assisted Diagnosis
KW - Parkinson's Disease
KW - Prediction
KW - Speech Characteristics
KW - Disease Course
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 1989-98644-000
AN - 1989-98644-000
AU - Henk, Matthew L.
ED - Henk, Matthew L.
T1 - Social work in primary care.
T3 - Sage sourcebooks for the human services series, Vol. 8
Y1 - 1989///
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-8039-3035-6
SN - 0-8039-3036-4
N1 - Accession Number: 1989-98644-000. Partial author list: First Author & Affiliation: Henk, Matthew L.; US Public Health Service, Public Health Social Work Consultant, Kansas City, MO, US. Release Date: 19890101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 0-8039-3035-6, Hardcover; 0-8039-3036-4, Paperback. Language: English. Major Descriptor: Health Care Services; Social Casework; Social Workers. Classification: Health Psychology & Medicine (3360). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 204.
AB - This volume is intended to prepare social work students and practitioners to function in primary care settings. During the last 15 years 'primary care' has emerged as a dominant force in American medicine. Improvements in the health status of patients will no longer occur as a result of technology and specialized treatments, but rather as a result of early detection and treatment of diseases; the development of health promotion and disease prevention programs; and the treatment of psychosocial problems. Social workers have an important and pivotal role in these efforts. Although physicians and other medical staff need to become involved in the development of prevention programs and in the solution of psychosocial problems, they do not always have the time or ability to do so. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
AB - If social workers are to integrate successfully into primary care settings, we need to understand the goals and values of primary care. More important, however, we must have a clear idea of the roles, functions, and tasks we could perform in this type of setting. Consequently, much of this text focuses on role definitions. The text also provides information on the history of social work in health care and primary care, interprofessional collaboration, a model for integration of social work in the educational setting, the physician's and administrator's perspectives, record keeping and data management, and future trends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Health Care Services
KW - Social Casework
KW - Social Workers
KW - 1989
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1989-98644-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 1989-98031-000
AN - 1989-98031-000
AU - Koslow, Diane R.
AU - Salett, Elizabeth Pathy
ED - Koslow, Diane R.
ED - Salett, Elizabeth Pathy
T1 - Crossing cultures in mental health.
Y1 - 1989///
CY - Washington, DC, US
PB - SIETAR International
SN - 0-933934-15-7
N1 - Accession Number: 1989-98031-000. Partial author list: First Author & Affiliation: Koslow, Diane R.; US Public Health Service, Consultant, Rockville, MD, US. Release Date: 19890101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 0-933934-15-7, Paperback. Language: English. Major Descriptor: Counseling; Cross Cultural Differences. Minor Descriptor: Communication Skills; Culture Shock; Ethnic Values; Immigration; Refugees. Classification: Psychotherapy & Psychotherapeutic Counseling (3310); Culture & Ethnology (2930). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 154.
AB - This book is addressed to mental health professionals, trainers, and others who work in the field of cross-cultural counseling. Its goal is to provide the reader with suggestions for improving skills in cross-cultural communication and to address specific issues of relevance in work with refugee, immigrant, and sojourner populations. In Part One, 'Cross-Cultural Communication,' Katharine G. Baker describes an experiential training model in which participants are challenged to explore and sharpen their awareness of their own cultural biases and values. Orlando L. Taylor then discusses some of the cultural assumptions that may prevent effective cross-cultural dialogue in the counseling situation and, in turn, may lead to distortions in service delivery. In Part Two, 'Cross-Cultural Counseling,' a number of specific issues faced by immigrants and refugees are discussed. Immigrants, who typically come to this country seeking a better future or to join other family members, tend to experience less trauma than refugees, but they too must often cope with loss, readjustment, and in many cases, discrimination. Part Three, 'Working with Sojourners,' addresses issues facing individuals and families who have chosen to reside temporarily in another country. Students, diplomatic and military personnel, and persons employed by multinational companies or international organizations who live abroad for a period of time often must cope with culture shock and culture fatigue while abroad, as well as adjustment difficulties upon returning home. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 1989
KW - Counseling
KW - Cross Cultural Differences
KW - Communication Skills
KW - Culture Shock
KW - Ethnic Values
KW - Immigration
KW - Refugees
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Williamson, David F.
AU - Serdula, Mary K.
AU - Kendrick, Juliette S.
AU - Binkin, Nancy J.
T1 - Comparing the Prevalence of Smoking in Pregnant and Nonpregnant Women, 1985 to 1986.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/06/
VL - 261
IS - 1
M3 - Article
SP - 70
EP - 74
SN - 00987484
AB - Provides interim estimates of the difference in the prevalence of smoking between pregnant and nonpregnant women in the U.S. overall and by age, race and education. Smoking behavior of unmarried pregnant women; Use of cross-sectional data collected from 1985 through 1986 from 25 states and the District of Columbia, in which pregnant and nonpregnant women were included in the same sampling frame.
KW - PREGNANT women -- Tobacco use
KW - WOMEN -- Substance use
KW - DEMOGRAPHY
KW - UNITED States
N1 - Accession Number: 10949529; Williamson, David F. 1; Serdula, Mary K. 1; Kendrick, Juliette S. 1; Binkin, Nancy J. 1; Source Information: 1/6/89, Vol. 261 Issue 1, p70; Subject: PREGNANT women -- Tobacco use; Subject: WOMEN -- Substance use; Subject: DEMOGRAPHY; Geographic Terms: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Koop, C. Everett
T1 - The Silver Anniversary.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/06/
VL - 261
IS - 1
M3 - Editorial
SP - 98
EP - 99
SN - 00987484
AB - Editorial. Analyzes the major developments related to smoking and health that have occurred in the U.S. since 1964, the year in which the historic report of the Surgeon General's Advisory Committee on Smoking and Health was released to then Surgeon General Luther L. Terry. Decrease in the prevalence of cigarette smoking among adults; Profitability of the cigarette industry despite declining sales.
KW - SMOKING
KW - CIGARETTE industry
KW - TERRY, Luther L. (Luther Leonidas), 1911-1985
KW - UNITED States
N1 - Accession Number: 10949535; Koop, C. Everett 1; Source Information: 1/6/89, Vol. 261 Issue 1, p98; Subject: SMOKING; Subject: CIGARETTE industry; Subject: TERRY, Luther L. (Luther Leonidas), 1911-1985; Geographic Terms: UNITED States; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Forbes, Allan L.
AU - Adams, Catherine E.
AU - JArnaud, Maurice
AU - Chichester, C. O.
AU - Cook, James D.
AU - Harrison, Bertha N.
AU - Hurrell, Richard F.
AU - Kahn, Samuel G.
AU - Morris, Eugene R.
AU - Tanner, James T.
AU - Whittaker, Paul
T1 - Comparison of in vitro, animal, and clinical determinations of iron bioavailability: International Nutritional Anemia Consultative Group Task Force report on iron bioavailability.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/02//
VL - 49
IS - 2
M3 - Article
SP - 225
EP - 238
SN - 00029165
AB - Relative bioavailability oftwo iron fortificants, electrolytic Fe and ferric orthophosphate, was related to that of the reference ferrous sulfate with in vitro and rat model depletion-repletion methods in four laboratories to compare values directly with those obtained in a parallel human study. In vitro testing was performed on Fe compounds with both solubility and dialysis in a simulated in vitro gastrointestinal digestion system. Two depletion-repletion techniques, hemoglobin-regeneration efficiency (HRE) and an official method of the Association of Official Analytical Chemists (AOAC), were examined. AOAC relative biological values (RBV) of electrolytic Fe were 0.66 and 0.78 and of FePO4 were 0.25 and 0.34. HRE values were 0.78 and 0.58 for electrolytic Fe and FePO4, respectively. When compared with FeSO4 in a radiolabeled farina-based meal fed to humans, the RBV of FePO4 was 0.25 and electrolytic Fe 0.75. Results obtained with the AOAC method serve as the most reliable prediction of Fe bioavailability in the human although in vitro dialysis is a promising screening technique. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOAVAILABILITY
KW - Ferrous sulfate
KW - Iron
KW - Electrolytic iron
KW - Orthophosphates
KW - Hemodialysis
KW - ascorbic acid
KW - in vitro
KW - Iron
KW - iron bioavailability
N1 - Accession Number: 91692360; Forbes, Allan L. 1,2,3,4,5,6; Adams, Catherine E. 1,2,3,4,5,6; JArnaud, Maurice 1,2,3,4,5,6; Chichester, C. O. 1,2,3,4,5,6; Cook, James D. 1,2,3,4,5,6; Harrison, Bertha N. 1,2,3,4,5,6; Hurrell, Richard F. 1,2,3,4,5,6; Kahn, Samuel G. 1,2,3,4,5,6; Morris, Eugene R. 1,2,3,4,5,6; Tanner, James T. 1,2,3,4,5,6; Whittaker, Paul 1,2,3,4,5,6; Affiliations: 1: Food and Drug Administration, Washington, DC; 2: International Life Sciences Institute-Nutrition Foundation, Washingon, DC; 3: Nestle Research Centre, Lausanne, Switzerland; 4: University of Kansas Medical Center, Kansas City, KS; 5: Agency for International Development, Washington, DC; 6: US Department of Agriculture, Beltsville, MD; Issue Info: Feb1989, Vol. 49 Issue 2, p225; Thesaurus Term: BIOAVAILABILITY; Thesaurus Term: Ferrous sulfate; Subject Term: Iron; Subject Term: Electrolytic iron; Subject Term: Orthophosphates; Subject Term: Hemodialysis; Author-Supplied Keyword: ascorbic acid; Author-Supplied Keyword: in vitro; Author-Supplied Keyword: Iron; Author-Supplied Keyword: iron bioavailability; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pierce, John P.
T1 - International Comparisons of Trends in Cigarette Smoking Prevalence.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/02//
VL - 79
IS - 2
M3 - Article
SP - 152
EP - 157
PB - American Public Health Association
SN - 00900036
AB - Data on smoking prevalence since 1974 are presented for the United States, Canada, Great Britain, Australia, Norway and Sweden. During this period, sex-specific prevalence has decreased in all the countries, studied, with the exception of Norway, where women showed an increase. There are also a considerable decline in uptake of smoking by the young over this period, suggestion that the observed decline in prevalence is likely to continue. In the United States, the rate of decline in adult smoking prevalence has been linear. This linear pattern is probably similar in prevalence in most other countries studied, with the notable exception of Australia, which demonstrated no change for the majority of the period. Among the six countries studied, the United States had neither the lowest smoking prevalence nor the fastest rate of decline over the period. Differential patterns of change infer that the successful public health interventions in some countries are not being applied in others. While the lack of change in Australia prior to 1983 is surprising, this was followed by a sizable drop in smoking prevalence for both higher and lower educational group in conjunction with the introduction of mass media-led antismoking campaigns. Most of the other countries report an ever increasing gap in prevalence between higher and lower educational groups. These findings suggest that all countries might benefit from a greater exchange of antismoking ideas and public health action. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Smoking
KW - Cigarette smokers
KW - RESEARCH
KW - Cigar smoking
KW - Smoking -- Abstracts
KW - Smoking -- Evaluation
KW - Cigarette smokers
KW - United States
KW - Australia
KW - Great Britain
N1 - Accession Number: 4682697; Pierce, John P. 1; Affiliations: 1: Office on Smoking and Health, Center for Chromic Disease Prevention, Centers for Disease Control, US Public Health Service; Issue Info: Feb1989, Vol. 79 Issue 2, p152; Thesaurus Term: Smoking; Thesaurus Term: Cigarette smokers; Thesaurus Term: RESEARCH; Thesaurus Term: Cigar smoking; Subject Term: Smoking -- Abstracts; Subject Term: Smoking -- Evaluation; Subject Term: Cigarette smokers; Subject: United States; Subject: Australia; Subject: Great Britain; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1992-13637-001
AN - 1992-13637-001
AU - Williams, Robert
T1 - Illness visualization and therapeutic adherence.
JF - The Journal of Family Practice
JO - The Journal of Family Practice
JA - J Fam Pract
Y1 - 1989/02//
VL - 28
IS - 2
SP - 185
EP - 192
CY - US
PB - Dowden Health Media
SN - 0094-3509
SN - 1533-7294
N1 - Accession Number: 1992-13637-001. PMID: 2915203 Partial author list: First Author & Affiliation: Williams, Robert; US Public Health Service, Indian Health Service Hosp, Crownpoint, NM, US. Release Date: 19920401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Ear Disorders; Imagery; Treatment Compliance. Minor Descriptor: Middle Ear. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: Feb, 1989.
AB - To identify a quick, inexpensive intervention for improving adherence to therapeutic plans for acute otitis media, a strategy supported by the health belief model was tested on 141 children (mean age less than 1 yr) and their caretakers. To augment education efforts, caretakers were shown the physical findings of acute otitis media in their child. The intervention test showed no effects on follow-up appointment-keeping behavior or on intermediate clinical outcome. The health belief model was not sustained by this test. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - illness visualization
KW - adherence to therapeutic plan
KW - children with acute otitis media & their caretakers
KW - 1989
KW - Ear Disorders
KW - Imagery
KW - Treatment Compliance
KW - Middle Ear
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Backinger, Cathy
T1 - PERSONAL SERVICE WORKERS: A CRITICAL LINK IN THE AIDS EDUCATION CHAIN?
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 1989///Spring1989
VL - 1
IS - 1
M3 - Article
SP - 31
EP - 38
SN - 08999546
AB - The article examines the need to disseminate information and education concerning AIDS and infection control to personal service workers. Personal service workers are those individuals whose occupation involve a close personal contact with clients. Hepatitis B virus and HIV infection are considered as an occupational risks for personal service workers. There are several state requirements for selected personal service workers occupations. For instance, a person who practice acupuncture is required to be a licensed physician. The states license cosmetologists through the State Boards of Cosmetology.
KW - AIDS (Disease)
KW - Communicable diseases
KW - Alternative medicine
KW - PREVENTION
KW - Hepatitis B virus
KW - HIV infections
KW - Acupuncture
KW - Physicians
KW - Cosmetologists
N1 - Accession Number: 19720638; Backinger, Cathy 1; Affiliations: 1: Division of Professional Practices, Center for Devices and Radiological Health, Department of Health and Human Services, Public Health Service, Food & Drug Administration, (HFZ-250), Rockville, MD 20857; Issue Info: Spring1989, Vol. 1 Issue 1, p31; Thesaurus Term: AIDS (Disease); Thesaurus Term: Communicable diseases; Thesaurus Term: Alternative medicine; Subject Term: PREVENTION; Subject Term: Hepatitis B virus; Subject Term: HIV infections; Subject Term: Acupuncture; Subject Term: Physicians; Subject Term: Cosmetologists; NAICS/Industry Codes: 812116 Unisex hair salons; NAICS/Industry Codes: 812112 Beauty Salons; NAICS/Industry Codes: 812115 Beauty salons; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Looker, Anne C.
AU - Johnson, Clifford L.
AU - McDowell, Margaret A.
AU - Yetley, Elizabeth A.
T1 - Iron status: prevalence of impairment in three Hispanic groups in the United States.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/03//
VL - 49
IS - 3
M3 - Article
SP - 553
EP - 558
SN - 00029165
AB - Little is known about the iron status of Hispanic groups in the United States. Data from the Hispanic Health and Nutrition Examination Survey were used to estimate the prevalence of impaired Fe status for persons aged 5-74 y from three Hispanic groups: Mexican Americans (MAs), Cubans, and Puerto Ricans; prevalences were also calculated for non-Hispanic whites (NHWs) and non-Hispanic blacks (NHBs) using data from the second National Health and Nutrition Examination survey. A three-variable model called the MCV model was used to assess impaired Fe status. Prevalences based on the MCV model did not differ between Hispanic groups. Differences between Hispanics and non-Hispanics occurred only among 20-44-y-old females, where MAs had a higher prevalence than NHWs or NHBs. With this exception, these Hispanic groups do not appear to be at greater risk of impaired Fe status than non-Hispanics. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Iron
KW - Public health
KW - Nutritional status
KW - Disease prevalence -- Risk factors
KW - United States
KW - ethnic groups
KW - Iron status
KW - nutrition survey
N1 - Accession Number: 91692410; Looker, Anne C. 1,2; Johnson, Clifford L. 1,2; McDowell, Margaret A. 1,2; Yetley, Elizabeth A. 1,2; Affiliations: 1: Health Examination Statistics, National Center for Health Statistics, Hyattsville, MD; 2: Division of Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Mar1989, Vol. 49 Issue 3, p553; Thesaurus Term: Iron; Thesaurus Term: Public health; Subject Term: Nutritional status; Subject Term: Disease prevalence -- Risk factors; Subject: United States; Author-Supplied Keyword: ethnic groups; Author-Supplied Keyword: Iron status; Author-Supplied Keyword: nutrition survey; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Graitcer, Philip L.
T1 - Evaluating Community Interventions to Reduce Drunken Driving.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/03//
VL - 79
IS - 3
M3 - Article
SP - 271
EP - 271
PB - American Public Health Association
SN - 00900036
AB - The article introduces reports published within the issue, including one on the decreased incidence of automobile fatalities involving alcohol, and another on a successful community injury intervention designed to train drivers to self-regulate their blood alcohol concentrations.
KW - Prefaces & forewords
KW - Traffic accidents
N1 - Accession Number: 4685134; Graitcer, Philip L. 1; Affiliations: 1: Division of Injury Epidemiology and Control (Mail Stop F36), Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333; Issue Info: Mar1989, Vol. 79 Issue 3, p271; Subject Term: Prefaces & forewords; Subject Term: Traffic accidents; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tanaka, Shiro
AU - Lee, Shiu T.
AU - Halperin, William E.
AU - Thun, Michael
AU - Smith, Blair
T1 - Reducing Knee Morbidity among Carpetlayers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/03//
VL - 79
IS - 3
M3 - Article
SP - 334
EP - 335
PB - American Public Health Association
SN - 00900036
AB - Abstract: Carpetlayers have a high prevalence of occupational knee morbidity, partly attributable to their use of the knee kicker to stretch carpet for wall-to-wall installation. While a mechanical alternative "power stretcher" is available, knee kickers are still widely used. A questionnaire survey indicated that unavailability of the mechanical stretcher at installation sites was a major factor for continued use of the knee kicker. Strategies to reduce use of the knee kicker are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Diseases
KW - Knee -- Diseases
KW - Carpet laying
KW - Social science research
KW - Joints (Anatomy)
KW - Carpet laying -- Equipment & supplies
KW - Textiles
KW - Musculoskeletal system
N1 - Accession Number: 4685343; Tanaka, Shiro 1; Lee, Shiu T. 1; Halperin, William E. 1; Thun, Michael 1; Smith, Blair 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Mar1989, Vol. 79 Issue 3, p334; Thesaurus Term: Occupational diseases; Thesaurus Term: Diseases; Subject Term: Knee -- Diseases; Subject Term: Carpet laying; Subject Term: Social science research; Subject Term: Joints (Anatomy); Subject Term: Carpet laying -- Equipment & supplies; Subject Term: Textiles; Subject Term: Musculoskeletal system; NAICS/Industry Codes: 238330 Flooring Contractors; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 424310 Piece Goods, Notions, and Other Dry Goods Merchant Wholesalers; NAICS/Industry Codes: 414130 Piece goods, notions and other dry goods merchant wholesalers; NAICS/Industry Codes: 314999 All Other Miscellaneous Textile Product Mills; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-29726-001
AN - 1989-29726-001
AU - O'Carroll, Patrick W.
AU - Mercy, James A.
T1 - Regional variation in homicide rates: Why is the West so violent?
JF - Violence and Victims
JO - Violence and Victims
JA - Violence Vict
Y1 - 1989///Spr 1989
VL - 4
IS - 1
SP - 17
EP - 25
CY - US
PB - Springer Publishing
SN - 0886-6708
N1 - Accession Number: 1989-29726-001. PMID: 2487123 Partial author list: First Author & Affiliation: O'Carroll, Patrick W.; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control, Atlanta, GA, US. Release Date: 19890901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Geography; Homicide; Racial and Ethnic Differences. Minor Descriptor: Blacks; Whites. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Page Count: 9. Issue Publication Date: Spr 1989.
AB - Calculated age-adjusted homicide rates for each of 3 race categories (White, Black, and other) for each state and region in the US in 1980, using data compiled by the National Center for Health Statistics. It was found that for each race group, homicide rates were highest, not in the South, but in the West. Homicide rates for Blacks were lower in the South than in any other region of the country. The authors infer that, for 1980 at least, the high crude homicide rate in the South results from the mutual effect of 2 factors: (1) Blacks have high homicide rates compared with Whites and (2) Blacks make up a larger proportion of the population in the South than in other regions of the country. It remains to be determined whether the age-adjusted, race-stratified rates of past decades also show this pattern. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homicide rates
KW - Whites & Blacks & other races
KW - 1980
KW - US states & regions
KW - 1989
KW - Geography
KW - Homicide
KW - Racial and Ethnic Differences
KW - Blacks
KW - Whites
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1989-30660-001
AN - 1989-30660-001
AU - Nelson, Scott H.
T1 - Values and priorities: Their effect on knowledge utilization in public mental health programs.
JF - Journal of Mental Health Administration
JO - Journal of Mental Health Administration
JA - J Ment Health Adm
Y1 - 1989///Spr 1989
VL - 16
IS - 1
SP - 44
EP - 49
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 0092-8623
N1 - Accession Number: 1989-30660-001. PMID: 10292251 Other Journal Title: The Journal of Behavioral Health Services & Research. Partial author list: First Author & Affiliation: Nelson, Scott H.; US Dept of Health & Human Services, Indian Health Service, US. Other Publishers: Springer. Release Date: 19890901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Information; Mental Health Services; Public Sector; Values. Minor Descriptor: Quality of Care. Classification: Community & Social Services (3373). Population: Human (10). Page Count: 6. Issue Publication Date: Spr 1989.
AB - Asserts that developing and maintaining shared values and priorities in public mental health systems is crucial to clinical, program, policy and administrative success. Issues of establishing priority populations, mobilizing resources, improving quality of care, and personal leadership style are discussed as examples of how such consensus contributed to progress in Pennsylvania's public mental health system. The 4 most important quality issues in the Pennsylvania mental health program include quality of patient-care staff, presence of patient advocacy/rights programs, quality assurance review processes, and hospital/community patient follow-up. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - shared values & priorities
KW - knowledge utilization in public mental health systems
KW - implications for quality of care
KW - 1989
KW - Health Care Delivery
KW - Information
KW - Mental Health Services
KW - Public Sector
KW - Values
KW - Quality of Care
KW - 1989
DO - 10.1007/BF02522185
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1989-30595-001
AN - 1989-30595-001
AU - Koop, C. Everett
T1 - Responding to the patient who has AIDS.
JF - Academic Medicine
JO - Academic Medicine
JA - Acad Med
Y1 - 1989/03//
VL - 64
IS - 3
SP - 113
EP - 115
CY - US
PB - Lippincott Williams & Wilkins
SN - 1040-2446
SN - 1938-808X
N1 - Accession Number: 1989-30595-001. PMID: 2923631 Other Journal Title: Journal of Medical Education. Partial author list: First Author & Affiliation: Koop, C. Everett; US Public Health Service, Rockville, MD, US. Release Date: 19890901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: 99th Annual Meeting of the Association of American Medical Colleges (1988, Chicago, Illinois). Major Descriptor: AIDS; Treatment. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 3. Issue Publication Date: Mar, 1989.
AB - Noting the medical tradition of caring for the sick and disabled regardless of what may have caused their condition, the present author discusses the need to support the will of individual physicians to respond to patients with acquired immune deficiency syndrome (AIDS). It is noted that physicians should be presented with specific guidelines regarding personal and professional behavior toward AIDS patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical tradition of caring for sick & role in treatment
KW - AIDS
KW - conference presentation
KW - 1989
KW - AIDS
KW - Treatment
KW - 1989
DO - 10.1097/00001888-198903000-00001
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Sugarman, Jonathan
AU - Percy, Carol
T1 - Prevalence of Diabetes in a Navajo Indian Community.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/04//
VL - 79
IS - 4
M3 - Article
SP - 511
EP - 513
PB - American Public Health Association
SN - 00900036
AB - Abstract: The age- and sex-adjusted prevalence of non-insulin-dependent diabetes mellitus (NIDDM) of 494 (76 per ¢) Navajo adults living in a reservation community was 10.2 per ¢, approximately 60 per ¢ > the estimated prevalence (6.4 per ¢) in the general US population. The screening protocol utilized likely underestimates the prevalence of NIDDM in this population. A high proportion of Navajo people were overweight when compared to the general US population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Population
KW - Non-insulin-dependent diabetes
KW - Older Navajo people
KW - Overweight persons
KW - Diabetes
KW - Carbohydrate intolerance
KW - Endocrine diseases
KW - Nutrition disorders
KW - United States
N1 - Accession Number: 4695578; Sugarman, Jonathan 1; Percy, Carol 1; Affiliations: 1: Public Health Service Hospital, Indian Health Service; Issue Info: Apr89, Vol. 79 Issue 4, p511; Thesaurus Term: Population; Subject Term: Non-insulin-dependent diabetes; Subject Term: Older Navajo people; Subject Term: Overweight persons; Subject Term: Diabetes; Subject Term: Carbohydrate intolerance; Subject Term: Endocrine diseases; Subject Term: Nutrition disorders; Subject: United States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1989-37645-001
AN - 1989-37645-001
AU - Mail, Patricia D.
AU - McKay, Ruth B.
AU - Katz, Mark
T1 - Expanding practice horizons: Learning from American Indian patients.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 1989/04//
VL - 13
IS - 2
SP - 91
EP - 102
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
N1 - Accession Number: 1989-37645-001. PMID: 10292286 Partial author list: First Author & Affiliation: Mail, Patricia D.; US Public Health Service, Rockville, MD, US. Release Date: 19891101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Client Education; Community Services; Cross Cultural Differences; Health Care Delivery. Minor Descriptor: Folk Medicine. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 12. Issue Publication Date: Apr, 1989.
AB - Asserts that the integration of Western medicine with traditional folk medical systems remains a current challenge to individuals providing patient education in Native American and Alaska Native communities. Cross-cultural patient education requires an understanding of contemporary native American Indian societies' cultural patterns, including theories of disease causality and therapy. Social organization and the relationship of the community to community-based health care delivery systems are important in making education relevant to prevailing values. The authors review the history of patient education to native American people, highlight some of the differences between traditional and allopathic approaches to patient care, and present a case history of a recent community-based patient education program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient education & integration of Western & folk medicine
KW - Native American & Alaska Native communities
KW - 1989
KW - American Indians
KW - Client Education
KW - Community Services
KW - Cross Cultural Differences
KW - Health Care Delivery
KW - Folk Medicine
KW - 1989
DO - 10.1016/0738-3991(89)90053-0
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cooper, Ellen C.
AU - Cooper, E C
T1 - Controlled clinical trials of AIDS drugs: the best hope.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/04/28/
VL - 261
IS - 16
M3 - journal article
SP - 2445
EP - 2445
SN - 00987484
AB - Focuses on the conduct of controlled clinical trials for anti-AIDS drugs in the U.S. Government position on the use of AIDS drugs; Effect of controlled trials on patient access to AIDS drugs.
KW - AIDS (Disease) -- Treatment
KW - CLINICAL trials
KW - HEALTH services accessibility
KW - UNITED States
N1 - Accession Number: 10865624; Cooper, Ellen C.; Cooper, E C 1; Source Information: 4/28/89, Vol. 261 Issue 16, p2445; Subject: AIDS (Disease) -- Treatment; Subject: CLINICAL trials; Subject: HEALTH services accessibility; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Calvert, Richard J.
AU - Krilchevsky, Evelyn S.
AU - Einhorn, Eugene
AU - Klurfeld, David M.
AU - Kritchevsky, David
T1 - An improved method for oxidation of chromium(III) oxide-containing fecal samples by using sodium peroxide fusion.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/05//
VL - 49
IS - 5
M3 - Article
SP - 901
EP - 903
SN - 00029165
AB - A safer method of oxidation of Cr2O3-containing fecal samples from transit-time studies was developed using sodium peroxide to replace perchloric acid as the oxidizing agent. The percentage recovery of Cr2O3 with this method was compared with that of a perchloric acid method for samples containing quantities of fecal ash and Cr2O3 typical of those from rodent transit-time studies. Both methods gave relatively constant percentage recoveries for Cr2O3 contents from 0.4 to 10 mg. Over this range, mean (±SD) percentage recoveries of Cr2O3 for sodium peroxide fusion and the perchloric acid method were 75.5 ± 4.3 and 89.9 ± 2.5, respectively. As long as percentage recovery is constant, the transit time as determined by calculation of the time of 80% excretion of the total recovered Cr2O3 is not affected. Sodium peroxide fusion provides a useful and safer alternative to perchloric acid oxidation in transit-time studies using Cr2O3 as a nonabsorbable marker. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sodium
KW - Perchloric acid
KW - Oxidation
KW - Chromium oxide
KW - Oxidizing agents
KW - chromium(III) oxide
KW - fecal samples
KW - perchloric acid
KW - safer oxidation
KW - sodium peroxide
KW - Transit time
N1 - Accession Number: 91731649; Calvert, Richard J. 1,2,3,4; Krilchevsky, Evelyn S. 1,2,3,4; Einhorn, Eugene 1,2,3,4; Klurfeld, David M. 1,2,3,4; Kritchevsky, David 1,2,3,4; Affiliations: 1: US Food and Drug Administration, Division of Nutrition, Experimental Nutrition Branch, Washington, DC; 2: Department of Chemistry, Life and Health Sciences, Spring Garden College, Philadelphia PA; 3: Wistar Institute, Philadelphia, PA; 4: Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA; Issue Info: May1989, Vol. 49 Issue 5, p901; Thesaurus Term: Sodium; Thesaurus Term: Perchloric acid; Thesaurus Term: Oxidation; Subject Term: Chromium oxide; Subject Term: Oxidizing agents; Author-Supplied Keyword: chromium(III) oxide; Author-Supplied Keyword: fecal samples; Author-Supplied Keyword: perchloric acid; Author-Supplied Keyword: safer oxidation; Author-Supplied Keyword: sodium peroxide; Author-Supplied Keyword: Transit time; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hayes, Ash E.
T1 - United States government policies and programs in nutrition and physical fitness.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1989/05//
VL - 49
IS - 5
M3 - Article
SP - 1039
EP - 1041
SN - 00029165
AB - The article provides details on the U.S. government policies and programs in nutrition and physical fitness carried by a number of agencies including the Departments of Education (DOE), Agriculture (DOA) and the Health and Human Services (HHS). It notes the programs of DOE focusing on school health education and physical education while food production and distribution for the DOA. The HHS is responsible for programs related to health services delivery, disease prevention and health promotion.
KW - Nutrition policy -- United States
KW - Physical fitness -- Government policy
KW - Physical activity
KW - School health services
KW - Physical education -- United States
KW - United States. Dept. of Education
KW - United States. Dept. of Agriculture
KW - United States. Dept. of Health & Human Services
N1 - Accession Number: 91731606; Hayes, Ash E. 1; Affiliations: 1: President's Council on Physical Fitness and Sports, Public Health Service, Department of Health and Human Services, Washington, DC; Issue Info: May1989, Vol. 49 Issue 5, p1039; Subject Term: Nutrition policy -- United States; Subject Term: Physical fitness -- Government policy; Subject Term: Physical activity; Subject Term: School health services; Subject Term: Physical education -- United States ; Company/Entity: United States. Dept. of Education ; Company/Entity: United States. Dept. of Agriculture ; Company/Entity: United States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steinberg, K.
AU - Garza, A.
AU - Bueso, J.
AU - Burse, V.
AU - Phillips, D.
T1 - Serum pesticide concentrations in farming cooperatives in Honduras.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1989/05//
VL - 42
IS - 5
M3 - Article
SP - 643
EP - 650
SN - 00074861
AB - The article presents a research study on the concentration of serum pesticide in farming cooperatives located in Honduras wherein population is exposed to heavy agricultural sprays. The study collected information on exposure index based on approximate residential distance from spraying area, pesticide spraying-related tasks, and years at the residence. It says that mean levels of dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyltrichloroethane (DDT) were higher in the exposed group.
KW - Spraying & dusting in agriculture
KW - Pesticides -- Physiological effect
KW - DDT (Insecticide) -- Environmental aspects
KW - Dichloroethylene
KW - Honduras
N1 - Accession Number: 70789357; Steinberg, K. 1; Garza, A.; Bueso, J. 2; Burse, V. 1; Phillips, D. 1; Affiliations: 1: Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, 30333 Atlanta USA; 2: Hospital Regional del Sur, Choluteca Honduras, CA; Issue Info: May1989, Vol. 42 Issue 5, p643; Thesaurus Term: Spraying & dusting in agriculture; Thesaurus Term: Pesticides -- Physiological effect; Thesaurus Term: DDT (Insecticide) -- Environmental aspects; Thesaurus Term: Dichloroethylene; Subject: Honduras; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF01700382
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Barkdoll, Gerald L.
T1 - Wobewithus Performance Management.
JO - Public Administration Review
JF - Public Administration Review
Y1 - 1989/05//May/Jun89
VL - 49
IS - 3
M3 - Letter
SP - 295
PB - Wiley-Blackwell
SN - 00333352
AB - Presents a letter to the editor about performance evaluation and management.
KW - EMPLOYEES -- Rating of
KW - PERSONNEL management
KW - EMPLOYEE motivation
KW - LETTERS to the editor
KW - PERFORMANCE
KW - SELF-perception
KW - LAKE Wobegon (Minn. : Imaginary place)
N1 - Accession Number: 4595271; Barkdoll, Gerald L. 1; Affiliations: 1: Associate Commissioner for Planning and Evaluation, Food and Drug Administration.; Issue Info: May/Jun89, Vol. 49 Issue 3, p295; Thesaurus Term: EMPLOYEES -- Rating of; Thesaurus Term: PERSONNEL management; Thesaurus Term: EMPLOYEE motivation; Subject Term: LETTERS to the editor; Subject Term: PERFORMANCE; Subject Term: SELF-perception; Subject Term: LAKE Wobegon (Minn. : Imaginary place); NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Nightingale, Stuart I.
AU - Rheinstein, Peter H.
AU - Morrison, James C.
T1 - To the Editor.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/05/05/
VL - 261
IS - 17
M3 - Article
SP - 2499
SN - 00987484
AB - Comments on the article 'Increased Seizure Frequency With Generic Primodone,' by Elaine Wyllie and colleagues at the Cleveland Clinic Foundation and published in the September 4, 1987 issue of the Journal of the American Medical Association. Description of the poor response of one patient to administration of primidone for the control of epileptic seizures; Outcome of the investigation conducted by the U.S. Food and Drug Administration on the case.
KW - CONVULSIONS
KW - DRUGS -- Side effects
KW - EPILEPSY
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 10811121; Nightingale, Stuart I. 1; Rheinstein, Peter H. 1; Morrison, James C. 1; Source Information: 5/5/89, Vol. 261 Issue 17, p2499; Subject: CONVULSIONS; Subject: DRUGS -- Side effects; Subject: EPILEPSY; Subject: UNITED States. Food & Drug Administration; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Richwald, Gary A.
AU - Sekier, Joan C.
AU - Kitimbo, David W.
AU - Friedland, Joan M.
T1 - PUBLIC HEALTH STUDENTS' KNOWLEDGE OF AIDS: IMPLICATIONS FOR HIV-RELATED TRAINING NEEDS.
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 1989///Summer1989
VL - 1
IS - 2
M3 - Article
SP - 89
EP - 95
SN - 08999546
AB - This article presents a study of public health students' knowledge and attitudes toward HIV and AIDS. Study subjects were graduate students enrolled in the University of California-Los Angeles, California School of Public Health. All subjects were given a 60-item questionnaire on knowledge about HIV and AIDS in five areas: prevalence, testing and reporting, minorities and AIDS, prevention, and international issues. Based on evaluations, most were able to correctly answer questions relating to HIV testing and AIDS reporting, while considerably fewer could do so for questions concerning HIV transmission and AIDS in intravenous drug users, women, prostitutes and children. Researchers concluded that there is considerably high unmet training needs in the area among health professionals in schools of public health.
KW - AIDS (Disease)
KW - HIV (Viruses)
KW - Communicable diseases
KW - Public health
KW - College students -- Attitudes
KW - Health behavior
KW - Public health personnel
KW - Health education
KW - California
N1 - Accession Number: 19720641; Richwald, Gary A. 1; Sekier, Joan C. 1; Kitimbo, David W. 1; Friedland, Joan M. 2; Affiliations: 1: Division of Population and Family Health, UCLA School of Public Health; 2: National Institute of Occupational Safety and Health; Issue Info: Summer1989, Vol. 1 Issue 2, p89; Thesaurus Term: AIDS (Disease); Thesaurus Term: HIV (Viruses); Thesaurus Term: Communicable diseases; Thesaurus Term: Public health; Subject Term: College students -- Attitudes; Subject Term: Health behavior; Subject Term: Public health personnel; Subject Term: Health education; Subject: California; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Muller, Keith E.
AU - Barton, Curtis N.
T1 - Approximate Power for Repeated-Measures ANOVA Lacking Sphericity.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1989/06//
VL - 84
IS - 406
M3 - Article
SP - 549
SN - 01621459
AB - Violation of sphericity of covariance across repeated measures inflates Type I error rates in univariate repeated-measures analysis of variance. Hence the use of Geisser--Greenhouse epsilon or Huynh-Feldt epsilon is now common (to provide improved Type I error rate), With nonsphericity, no method has been available to compute power. A convenient method is suggested for approximating power and test size under nonsphericity. New approximations are suggested for (a) a weighted sum of independent noncentral chi[sup 2]'s, (b) the trace of a noncentral Wishart (or pseudo-Wishart)matrix, (c) the expected values of epsilon and epsilon, and (d) the noncentral test statistic, whether corrected or uncorrected, The new approximations are extensions of the work of Box (1954a,b) and Satterthwaite (194l), The method performed well when evaluated against published and new simulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of variance
KW - APPROXIMATION theory
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - CORRELATION (Statistics)
KW - ERRORS
KW - CHI-squared test
KW - EXPONENTS (Algebra)
KW - Equicorrelation
KW - Error rates
KW - Noncentral chi square
KW - Noncentral pseudo-Wishart
KW - Noncentral Wishart
KW - Sample size.
N1 - Accession Number: 4622438; Muller, Keith E. 1; Barton, Curtis N. 2; Affiliations: 1: Associate Professor, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599.; 2: Mathematical Statistician, Experimental Design and Evaluation Branch, U.S. Food and Drug Administration, Washington, DC 20204.; Issue Info: Jun89, Vol. 84 Issue 406, p549; Thesaurus Term: ANALYSIS of variance; Thesaurus Term: APPROXIMATION theory; Thesaurus Term: REGRESSION analysis; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: CORRELATION (Statistics); Subject Term: ERRORS; Subject Term: CHI-squared test; Subject Term: EXPONENTS (Algebra); Author-Supplied Keyword: Equicorrelation; Author-Supplied Keyword: Error rates; Author-Supplied Keyword: Noncentral chi square; Author-Supplied Keyword: Noncentral pseudo-Wishart; Author-Supplied Keyword: Noncentral Wishart; Author-Supplied Keyword: Sample size.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 1990-01669-001
AN - 1990-01669-001
AU - Tower, Margene
T1 - A suicide epidemic in an American Indian community.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1989///Sum 1989
VL - 3
IS - 1
SP - 34
EP - 44
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1990-01669-001. PMID: 2490221 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Tower, Margene; Billings Area Indian Health Service, MT, US. Release Date: 19900101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Attempted Suicide; Suicide. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: Sum 1989.
AB - Describes the suicidal epidemic that occurred on the Wind River Reservation during August and September of 1985. During this period, there were 12 reported deaths (Ss aged 14–26 yrs) from suicide and an additional 88 verifiable suicide attempts or threats. Discussion of the Wind River experience begins with an overview of suicides and attempted suicides and a brief summary of the epidemic itself. A 3-stage model for intervention during an epidemic is presented, and proposed long-term programs are described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide deaths & attempts
KW - 0–69 yr old residents of Wind River Indian reservation
KW - 1989
KW - American Indians
KW - Attempted Suicide
KW - Suicide
KW - 1989
DO - 10.5820/aian.0301.1989.34
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1990-01669-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Valway, Sarah E.
AU - Martyny, John W.
AU - Miller, Jeffrey R.
AU - Cook, Magdalena
AU - Mangione, Ellen J.
T1 - Lead Absorption in Indoor Firing Range Users.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/08//
VL - 79
IS - 8
M3 - Article
SP - 1029
EP - 1032
PB - American Public Health Association
SN - 00900036
AB - Abstract: To determine if users of indoor firing ranges may be at risk from lead exposure, we studied a law enforcement trainee class during three months of firearms instruction. Blood lead levels were obtained before training and at four-week intervals during training. Air lead levels were measured three times during instruction. Blood lead levels rose from a pre-training mean of 0,31 µ mol/L to 2.47 µ mol/ L. Mean air lead levels were above 2,000 µ g/m&sup 3;, more than 40 times the Occupational Safety and Health Administration's standard of 50 µ g/m&sup 3;. Cumulative exposure to lead and the change in blood lead were positively correlated. Control measures need to be studied to determine their efficacy in decreasing or eliminating this health risk. (Am J Public Health 1989; 79:1029-1032.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lead -- Toxicology
KW - Public health
KW - Industrial safety
KW - Bombing & gunnery ranges
KW - Law enforcement
KW - Firearms
KW - Police training
KW - Government agencies
KW - Blood analysis
N1 - Accession Number: 4685364; Valway, Sarah E. 1,2; Martyny, John W. 3; Miller, Jeffrey R. 4; Cook, Magdalena 4; Mangione, Ellen J. 4; Affiliations: 1: Medical Epidemiologist, Diabetes Program, Indian Health Service, 2401 12th Street, NW, Albuquerque, NM 87102; 2: Division of Field Services, Epidemiology Program, Centers for Disease Control; 3: Tri-County Health Department, Englewood, CO.; 4: Colorado Department of Health, Division of Disease Control and Environmental Epidemiology, Denver; Issue Info: Aug1989, Vol. 79 Issue 8, p1029; Thesaurus Term: Lead -- Toxicology; Thesaurus Term: Public health; Thesaurus Term: Industrial safety; Subject Term: Bombing & gunnery ranges; Subject Term: Law enforcement; Subject Term: Firearms; Subject Term: Police training; Subject Term: Government agencies; Subject Term: Blood analysis; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 332992 Small Arms Ammunition Manufacturing; NAICS/Industry Codes: 451119 All other sporting goods stores; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 611519 Other Technical and Trade Schools; NAICS/Industry Codes: 611510 Technical and trade schools; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roscoe, Robert J.
AU - Steenland, Kyle
AU - Halperin, William E.
AU - Beaumont, James J.
AU - Waxweiler, Richard J.
T1 - Lung Cancer Mortality Among Nonsmoking Uranium Miners Exposed to Radon Daughters.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/08/04/
VL - 262
IS - 5
M3 - Article
SP - 629
EP - 633
SN - 00987484
AB - Estimates the risk of lung cancer mortality among nonsmokers exposed to varying levels of radon daughters. Comparison of observations between white miners with no smoking experience and mortality rates for nonsmokers of U.S. Veterans; Revelation of more deaths with the miners group; Confirmation of radon exposure's carcinogen potency.
KW - LUNGS -- Cancer
KW - PASSIVE smoking
KW - RADON
KW - MINERS
KW - CARCINOGENS
N1 - Accession Number: 10940888; Roscoe, Robert J. 1; Steenland, Kyle 1; Halperin, William E. 2; Beaumont, James J. 3; Waxweiler, Richard J. 4; Source Information: 8/4/89, Vol. 262 Issue 5, p629; Subject: LUNGS -- Cancer; Subject: PASSIVE smoking; Subject: RADON; Subject: MINERS; Subject: CARCINOGENS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Nelson, Mary
AU - Smith, Linda S.
AU - Reeves, Kate
AU - Safayan, Zinat
AU - Smith, Theodore C.
AU - Mitchell, Jimmy
T1 - LETTERS.
JO - RN
JF - RN
Y1 - 1989/09//
VL - 52
IS - 9
M3 - Letter
SP - 8
EP - 71
SN - 00337021
AB - Comments on issues related to nursing care published in 'RN.'
KW - NURSING
KW - NURSES
N1 - Accession Number: 4935778; Nelson, Mary 1; Smith, Linda S. 2; Reeves, Kate 3; Safayan, Zinat 4; Smith, Theodore C. 5; Mitchell, Jimmy 6; Source Information: Sep89, Vol. 52 Issue 9, p8; Subject: NURSING; Subject: NURSES; Number of Pages: 2p; Document Type: Letter; Full Text Word Count: 721
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1990-12596-001
AN - 1990-12596-001
AU - Mail, Patricia D.
T1 - American Indians, stress, and alcohol.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1989///Fal 1989
VL - 3
IS - 2
SP - 7
EP - 26
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1990-12596-001. PMID: 2490294 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Mail, Patricia D.; US Dept of Health & Human Services, Office of the Surgeon General, Rockville, MD, US. Release Date: 19900501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Alcohol Drinking Patterns; American Indians; Literature Review; Stress. Minor Descriptor: Health Care Services. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Methodology: Literature Review. Page Count: 20. Issue Publication Date: Fal 1989.
AB - Reviews research relevant to the hypothesized causal relationship of stress to drinking among Native Americans and to alcohol's role as a stressor. Stress related to sociocultural, biological, and psychological factors experienced by Native Americans is discussed as a means of explaining alcohol use and abuse within this population. Major studies of causal factors that contribute to alcohol use and abuse within American Indian communities are cited. Evidence for alcohol abuse as a cause of stress is also presented. Implications for providing medical care to American Indians are discussed, and means of ameliorating stress in these communities are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - stress & alcohol use & abuse
KW - American Indians
KW - literature review
KW - implications for health care services
KW - 1989
KW - Alcohol Abuse
KW - Alcohol Drinking Patterns
KW - American Indians
KW - Literature Review
KW - Stress
KW - Health Care Services
KW - 1989
DO - 10.5820/aian.0302.1989.7
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ford, Daniel E.
AU - Kamerow, Douglas B.
T1 - Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09/15/
VL - 262
IS - 11
M3 - Article
SP - 1479
EP - 1484
SN - 00987484
AB - Presents the results of a survey on the relationship between sleep disturbances and psychiatric disorders in the U.S. Risk of developing new major depression in persons who had insomnia; Prevalence and incidence of sleep disturbances; Relationship between age and insomnia and hypersomnia; Descriptive epidemiology.
KW - SLEEP disorders
KW - PSYCHIATRY
KW - MENTAL depression
KW - INSOMNIA
KW - UNITED States
N1 - Accession Number: 10982576; Ford, Daniel E. 1; Kamerow, Douglas B. 2; Source Information: 9/15/89, Vol. 262 Issue 11, p1479; Subject: SLEEP disorders; Subject: PSYCHIATRY; Subject: MENTAL depression; Subject: INSOMNIA; Geographic Terms: UNITED States; Number of Pages: 6p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Ginzburg, Harold M.
T1 - Needle Exchange Programs: A Medical or a Policy Dilemma?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/10//
VL - 79
IS - 10
M3 - Editorial
SP - 1350
EP - 1351
PB - American Public Health Association
SN - 00900036
AB - The article offers reports in connection with the needle exchange programs. The program aims to contain HIV in medical communities, due to sharing contaminated needles and syringes with infected partners. The section discusses the effects of the program in several cities in the United States. It also provides several insights given by some professionals in medical care regarding the program.
KW - AIDS (Disease)
KW - HIV (Viruses)
KW - Communicable diseases
KW - PREVENTION
KW - Immunological deficiency syndromes
KW - Sexually transmitted diseases
N1 - Accession Number: 4685606; Ginzburg, Harold M. 1; Affiliations: 1: Senior Medical Consultant, Bureau of Health Care Delivery and Assistance, Health Resources and Services Administration, Room 7-05, 5600 Fishers Lane, Rockville, MD 20857; Issue Info: Oct89, Vol. 79 Issue 10, p1350; Thesaurus Term: AIDS (Disease); Thesaurus Term: HIV (Viruses); Thesaurus Term: Communicable diseases; Subject Term: PREVENTION; Subject Term: Immunological deficiency syndromes; Subject Term: Sexually transmitted diseases; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1992-22003-001
AN - 1992-22003-001
AU - Hazell, Joseph W.
T1 - Drivers as mediators of stress response.
JF - Transactional Analysis Journal
JO - Transactional Analysis Journal
Y1 - 1989/10//
VL - 19
IS - 4
SP - 212
EP - 223
CY - US
PB - International Transactional Analysis Assn
SN - 0362-1537
SN - 2329-5244
N1 - Accession Number: 1992-22003-001. Partial author list: First Author & Affiliation: Hazell, Joseph W.; US Public Health Service Hosp, Stress Management Service, San Francisco, CA, US. Other Publishers: Sage Publications; The International Transactional Analysis Association. Release Date: 19920701. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attitude Measures; Habits; Stress Reactions; Test Construction. Minor Descriptor: Motivation; Personality Disorders; Checklist (Testing). Classification: Personality Scales & Inventories (2223); Personality Traits & Processes (3120). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 12. Issue Publication Date: Oct, 1989.
AB - Presents 5 belief systems called 'Drivers' as manifest in habits that are used to respond to the challenges or stresses of life. Many of these habits are useful when well moderated, but counterproductive when less controlled, and can even be the basis for major personality disorder. They are (1) be pleasing (BP), (2) be right (BR), (3) be strong (BES), (4) hurry up (HU), and (5) try hard (TH). BP habits are intended to obtain nurture and avoid abandonment; BR habits are intended to obtain respect and to avoid shame; BES habits are intended to obtain security and to avoid vulnerability; HU habits are intended to obtain gratification and avoid deprivation; and TH habits are intended to obtain reward and to avoid defeat. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - development of Drivers Checklist
KW - identification of belief systems manifest in habitual responses to stress
KW - 23–83 yr olds
KW - implications for personality disorder
KW - 1989
KW - Attitude Measures
KW - Habits
KW - Stress Reactions
KW - Test Construction
KW - Motivation
KW - Personality Disorders
KW - Checklist (Testing)
KW - 1989
DO - 10.1177/036215378901900406
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1992-22003-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Donohue, Robert E.
AU - Fauver, H. Earl
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/10/06/
VL - 262
IS - 13
M3 - Letter
SP - 1772
EP - 1772
SN - 00987484
AB - Presents a letter to the editor in the October 6, 1989 issue of the 'Journal of the American Medical Association,' noting that it is warranted to perform a renal ultrasound examination in patients who present with bilateral absence of the vas deferens.
KW - ULTRASONIC imaging
KW - KIDNEYS
KW - VAS deferens
KW - LETTERS to the editor
N1 - Accession Number: 10981843; Donohue, Robert E. 1; Fauver, H. Earl 2; Source Information: 10/6/89, Vol. 262 Issue 13, p1772; Subject: ULTRASONIC imaging; Subject: KIDNEYS; Subject: VAS deferens; Subject: LETTERS to the editor; Number of Pages: 1/4p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1990-13047-001
AN - 1990-13047-001
AU - Leukefeld, Carl G.
ED - Leukefeld, Carl G.
T1 - Evaluating programs in health care settings.
JF - Health & Social Work
JO - Health & Social Work
JA - Health Soc Work
Y1 - 1989/11//
VL - 14
IS - 4
SP - 231
EP - 234
CY - United Kingdom
PB - Oxford University Press
SN - 0360-7283
N1 - Accession Number: 1990-13047-001. PMID: 2599480 Partial author list: First Author & Affiliation: Leukefeld, Carl G.; US Public Health Service, National Inst on Drug Abuse, Rockville, MD, US. Release Date: 19900501. Correction Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Health Care Services; Prevention; Program Evaluation; Social Workers. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 4. Issue Publication Date: Nov, 1989.
AB - Reviews evaluation approaches frequently used by social workers to satisfy funding source requirements and presents an evaluation approach that avoids some common pitfalls. Three commonly used evaluation designs are (1) the use of pre- and postmeasures to compare a baseline with a postprogram result, (2) comparison of matched Ss who do and do not receive the program's benefits, and (3) comparison of a treatment group with a control group. It is suggested that use of a comparison group rather than a no-treatment control group may meet evaluation requirements while allowing everyone to receive treatment or intervention. Use of a comparative design to assess the impact of an acquired immune deficiency syndrome (AIDS) infection prevention program is described. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - program evaluation approaches
KW - evaluation of AIDS prevention program in health care setting
KW - social workers
KW - 1989
KW - AIDS
KW - Health Care Services
KW - Prevention
KW - Program Evaluation
KW - Social Workers
KW - 1989
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
TY - GEN
AU - Schweitzer, P.;
AU - Hartford, R.;
T1 - MEDICATION HISTORY INTERVIEW IN AN AMBULATORY CARE SETTING
CT - MEDICATION HISTORY INTERVIEW IN AN AMBULATORY CARE SETTING
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - P
EP - D
AD - Pine Ridge Indian Hospital, Public Health Service, Pharmacy Services, Pine Ridge, SD 57770, USA
N1 - Accession Number: 27-02164; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacy Practice; Information Processing and Literature
N2 - A thorough medication history can provide valuable information to health care providers about a patient and his medications. A medication history will assist the practitioner by providing a complete list of past and present medications a patient is taking, including over-the-counter medications. The pharmacist will determine if the patient is compliant or reliable in taking their medications. A medication history service is a valuable resource for outpatient pharmacies that are interested in improving patient compliance, providing additional services, and increasing the patient's respect for the pharmacists' expertise. The service involves training pharmacy staff or pharmacy students, developing a procedure to effectively implement the service, and obtaining the support of the medical staff so the service will be utilized appropriately. The report will describe the medication history ambulatory care service that has been implemented at our institution. The ambulatory care service at our institution promotes an excellent rapport between the pharmacist and the patient. The service is primarily utilized for patients with difficult regimens, patients with compliance problems, and those patients that request the service. Training pharmacy staff involves didactic material as well as practical experience. Patients selected for interviewing are determined by a "pharmacist screener" and usually are patients what present with medication problems (i.e., low therapeutic levels, non-compliance, confusion with medications or doses). The patients are counselled in a semi-private area. The interview usually involves educating the patient as well as obtaining medication information. The interview usually requires 10-15 minutes. The staff has been very receptive and willing to implement this program. All staff members are encoura ed to participate. The medical staff has appreciated the information obtained from the medication interviews. The medication interview has allowed the pharmacist to have a larger impact on the patients overall care.
KW - Practice Interest Areas--Ambulatory Care/Community Practice--meeting presentations;
KW - ASHP meeting abstracts--drug histories;
KW - Patient information--drug histories--ambulatory care pharmacy;
KW - Ambulatory care--drug histories--interviews;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Herrier, R. N.;
AU - Boyce, R. W.;
T1 - PATIENT CONSULTATION INDIAN HEALTH SERVICE STYLE: UNIQUE APPROACH TO VERIFYING PATIENT UNDERSTANDING OF PRESCRIBED MEDICATION USAGE
CT - PATIENT CONSULTATION INDIAN HEALTH SERVICE STYLE: UNIQUE APPROACH TO VERIFYING PATIENT UNDERSTANDING OF PRESCRIBED MEDICATION USAGE
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - P
EP - D
AD - Indian Health Service, Clinical Support Center, 4212 N. 16th Street, Phoenix, AZ 85016, USA
N1 - Accession Number: 27-02166; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacy Practice; Pharmaceutical Education
N2 - Since 1985, Indian Health Service (IHS) has taught a four day course to upgrade pharmacists; skills in areas required to function as a clinical pharmacist in IHS. Since IHS places a special emphasis on patient consultation, the major focus of the course is communication techniques required to effectively interact with patients and providers. The course begins with a home study module sent out eight weeks prior to the four day workshop. The workshop consists of four hours of lecture and thirty-two hours of role playing which includes evaluation of technique through video taping. Using open-ended questions, pharmacists are taught to initiate discussion regarding the purpose of the medication, its proper use, and self monitoring of its effects. Pharmacists learn first to identify and diffuse barriers to communications such as anger or fear. Then they use open-ended questions to get patients to verbalize or demonstrate necessary understanding. Pharmacist teaching is limited to "filling in gaps" of knowledge or skills and reinforcing positive responses. Prior to conclusion of the counseling session, patients verbalize or demonstrate their comprehension of key points required for correct compliance.
KW - Practice Interest Areas--General Clinical Practice--meeting presentations;
KW - ASHP meeting abstracts--patient consultation;
KW - Patient information--consultation--pharmacists training;
KW - Education, pharmaceutical--consultation--communication training;
KW - Communication--pharmacists--patient consultation training;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=27-02166&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Boyce, R. W.;
AU - Herrier, R. N.;
AU - Vandekerkhove, L.;
T1 - PRELIMINARY STUDY TO EVALUATE THE IMPACT OF PATIENT CONSULTATION TRAINING FOR INDIAN HEALTH SERVICE PHARMACISTS
CT - PRELIMINARY STUDY TO EVALUATE THE IMPACT OF PATIENT CONSULTATION TRAINING FOR INDIAN HEALTH SERVICE PHARMACISTS
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - P
EP - E
AD - Indian Health Service, Clinical Support Center, 4212 N. 16th Street, Phoenix, AZ 85016, USA
N1 - Accession Number: 27-02172; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacy Practice
N2 - The purpose of this study was to evaluate the effectiveness of consultative techniques taught in the Clinical Pharmacy Training Program (CPTP) in improving patients' understanding on how to properly use prescribed medication. An exit survey on patients receiving medications from the pharmacy was conducted at three IHS facilities. The pharmacy staff was unaware that this survey was being conducted. This survey not only evaluated patient understanding, but also explored patient satisfaction with their visit to the pharmacy. The three facilities differed in (1) availability of private consultation rooms, (2) department commitment to the use of interactive techniques taught in the CPTS, and (3) percent of staff trained through the CPTS. The results of the study indicated a strong correlation between adequate patient understanding and high patient satisfaction with; (1) the use of interactive consultative techniques taught at the CPTS, (2) the availability of private patient consultation rooms, and (3) the commitment of the pharmacy service to counsel patients using interactive techniques. At one facility with a model consultation program, 100% of the patients accurately verbalized what the prescribed medicine was for and how to properly use it. Eighty percent were able to describe expected drug effects and what to do if unusual effects occurred.
KW - Practice Interest Areas--Practice Research--meeting presentations;
KW - ASHP meeting abstracts--patient consultation education;
KW - Patient information--consultation--pharmacists education;
KW - Education, pharmaceutical--consultation--skills, impact;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=27-02172&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Johnson, J. M.;
T1 - FDA PERSPECTIVE OF ADVERSE DRUG REACTION MONITORING AND REPORTING
CT - FDA PERSPECTIVE OF ADVERSE DRUG REACTION MONITORING AND REPORTING
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - PI
EP - 63
AD - Reports Evaluation Branch, Food and Drug Administration, Rockville, MD, USA
N1 - Accession Number: 27-01801; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Adverse Drug Reactions; Legislation, Laws and Regulations
N2 - The Spontaneous Reporting System of the U.S. Food and Drug Administration includes a computerized data bank of approximately 500,000 reports of adverse events associated with the use of drugs and biologics; 60,000 reports are received annually. This surveillance system helps to assure the safety of prescription drugs and biologics. The hospital pharmacist is a major link in the surveillance and reporting. A hospital drug adverse event reporting system should include several components-surveillance and detection of adverse events; internal system must be a cooperative effort among medical and nursing staffs (and other clinical personnel), several hospital committees (Pharmacy and Therapeutics, Quality Assurance, etc.), and the hospital administration. Quality assurance efforts should be directed towards preventing adverse drug reactions. Reporting guidelines for the hospital pharmacist will be presented. Suggestions for implementing a hospital based adverse reaction reporting system will be made. This presentation will also provide a brief overview of the adverse reaction reporting regulations for those holding New Drug Applications.
KW - ASHP meeting abstracts--adverse reactions reporting;
KW - Drugs, adverse reactions--reporting--FDA perspective;
KW - Reports--drugs, adverse reactions--FDA perspective;
KW - Food and Drug Administration (U.S.)--drugs, adverse reactions--reporting, perspective;
KW - Regulations--drugs, adverse reactions--reporting, FDA perspective;
KW - Hospitals--drugs, adverse reactions--reporting programs;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=27-01801&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Church, R. M.;
AU - Lipman, A. G.;
AU - Dwight, V.;
AU - Herrier, R. N.;
AU - Boyce, R. W.;
AU - \ET/;
T1 - DEVELOPMENT AND IMPLEMENTATION OF STANDARDS OF PRACTICE FOR A MULTIPLE INSTITUTION SYSTEM OF HOSPITALS AND AMBULATORY CARE CENTERS
CT - DEVELOPMENT AND IMPLEMENTATION OF STANDARDS OF PRACTICE FOR A MULTIPLE INSTITUTION SYSTEM OF HOSPITALS AND AMBULATORY CARE CENTERS
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - MCS
EP - -33
AD - Pharmacy Branch, Indian Health Service, United States Public Health Service, Room 6A-44 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 27-01624; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2 - The objective of this case study was to formally define standards of practice which specify the purpose for and level of pharmaceutical services to be provided by all pharmacy services in a nationwide system of health care facilities. This case illustrates the development and strategy on instituting Standards of Practice for Pharmacy Services on a national basis. Local facility administrators, over the last two decades, have become more influential in defining pharmacy services at their facilities. These changes allowed growing inconsistency in the scope and level of services, program emphasis and method of program evaluation among IHS facilities even though there is general agreement among IHS pharmacists on what services should be provided. Because IHS pharmacists frequently transfer within the system, this inconsistency has created management problems and unrealistic expectations and frustrations among pharmacists who transfer from a facility offering one level of service to another. The lack of such standards has resulted at times in dramatic changes in pharmaceutical service at some facilities when staff have changed. The steps taken to develop and implement system wide standards of practice are given. The IHS Pharmacy Standards of Practice are the basis and authority for individual performance, program and facility review. Throughout the standards, the patient oriented value system is reasserted. More consistent level and scope of pharmaceutical services among the various facilities should result; this is now being evaluated.
KW - Management Case Studies--meeting presentations;
KW - ASHP meeting abstracts--hospital pharmacy standards;
KW - Pharmacy, institutional, hospital--services--standards of practice;
KW - Standards--pharmacy services--hospital, ambulatory care;
KW - Ambulatory care--standards--pharmacy services;
KW - Pharmacy services--standards--hospital, ambulatory care;
KW - Administration--pharmacy services--standards, hospital, ambulatory care;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=27-01624&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Nelson, R. C.;
T1 - PHARMACISTS AS INVESTIGATORS IN CLINICAL TRIALS: FDA'S PERSPECTIVE
CT - PHARMACISTS AS INVESTIGATORS IN CLINICAL TRIALS: FDA'S PERSPECTIVE
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1989/12/01/
VL - 24
IS - Dec
SP - SPG
EP - -11
AD - Office of Professional Development and Staff College, Center for Drug Evaluation and Research Food and Drug Administration, 5600 Fishers Lane Rockville, MD 20857, USA
N1 - Accession Number: 27-02137; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Pharmacy PracticeLegislation, Laws and Regulations
N2 - In response to the question: Can a pharmacist serve as an (principal) investigator for a clinical trial? The Food and Drug Administration (FDA) went on public record in 1980 & again in 1983 to state that qualified individuals who are not M.D.s can participate in clinical trials provided that an M.D. or D.C. is either a subinvestigator or is presented in the IND (Investigational New Drug Application) as an individual who will be responsible for drug administration and evaluation of patient safety. It is vital to understand that the FDA investigational new drug regulations are based on accepted ethical norms. Contemporary ethical norms were formulated by international convention. The norms of 1) good research design, and 2) competent investigators are most relevant to the question at hand. Basically, for a clinical trial to be ethical it must be expected to be relatively safe, and scientifically rigorous in its design, conduct and analysis. The word "COMPETENT" is used in at least wo respects: 1) adequate scientific training and skill to accomplish the purposes of the research, and 2) be sufficiently competent to care for the subject. Under section 505(i) of the Food Drug and Cosmetic Act (21 U.S.C. 355 (i)), the Agency is required to assure that the investigational drug will be provided only to "experts qualified by training and experience to investigate" a new drug. This raises the question of who is scientifically competent? It is clear that FDA has determined that non-physicians can be considered scientifically qualified to serve as investigators. However, the question remains: is there a level of clinical trial that demands the skill-set available only to the physician-scientist, therefore excluding a pharmacist from serving as the investigator? If the protocol makes it past the local Institutional Review Board (IRB), the final decision will be made on a case-by-case basis, within the appropriate new drug review division in response to a specific IND subm ssion and review of the information requested on Forms 1571 and 1572.
KW - ASHP meeting abstracts--pharmacists and clinical studies;
KW - Clinical studies--pharmacists--principal investigators, FDA viewpoint;
KW - Pharmacists--clinical studies--principal investigators, FDA viewpoint;
KW - Research--pharmacists--principal investigators, FDA viewpoint;
KW - Food and Drug Administration (U.S.)--clinical studies--pharmacists as principal investigators;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=27-02137&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Freund, Eugene
AU - Seligman, Paul J.
AU - Chorba, Terence L.
AU - Safford, Susan K.
AU - Drachman, Jonathan G.
AU - Hull, Harry F.
T1 - Mandatory Reporting of Occupational Diseases by Clinicians.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12//12/1/89
VL - 262
IS - 21
M3 - Article
SP - 3041
EP - 3044
SN - 00987484
AB - Focuses on the policy of mandatory reporting of occupational diseases by clinicians in the United States. Importance of occupational disease surveillance on the prevention of work-related injury and illness; Programs launched by states for occupational safety and health; Reportable occupational diseases and occupational disease-related conditions in the country.
KW - OCCUPATIONAL diseases -- Reporting
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 10982450; Freund, Eugene 1; Seligman, Paul J. 1; Chorba, Terence L. 2; Safford, Susan K. 2; Drachman, Jonathan G. 2; Hull, Harry F. 3; Source Information: 12/1/89, Vol. 262 Issue 21, p3041; Subject: OCCUPATIONAL diseases -- Reporting; Subject: MEDICAL policy; Geographic Terms: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Chen, James J.
AU - Kodell, Ralph L.
T1 - Quantitative Risk Assessment for Teratological Effects.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1989/12//
VL - 84
IS - 408
M3 - Article
SP - 966
SN - 01621459
AB - This article presents a quantitative procedure for using a "benchmark dose" to obtain low-dose risk estimates for reproductive and developmental toxic effects. This procedure combines the best features of the previously proposed methods for handling litter effects for teratology data and the currently used methods for quantitative risk assessment. The beta-binomial distribution is used to account for litter effects, and the Weibull dose-response model is used for modeling teratogenic effects. A benchmark dose, defined to be the lowest dose at which the excess risk does not exceed 1% with 95% confidence, is proposed to replace the no-observed-effect level (NOEL). The NOEL is generally the highest experimental dose that is not statistically different from the control; the NOEL approach does not use experimental data effectively for quantitative risk estimation. In this article, a lower limit on the safe dose is estimated by linearly extrapolating downward from the benchmark dose; this procedure is recommended because it is not strongly dependent on the model used in the data range. Linear extrapolation from a benchmark dose is essentially equivalent to the use of a safety factor in determining a safe dose from a NOEL. However, the linear extrapolation procedure reflects the risk at the estimated safe dose. Confidence limits on excess risks and safe doses are based on the beta-binomial likelihood ratio criterion rather than on the asymptotic distribution of the maximum likelihood estimates, because the latter have been shown to exhibit poor properties in the low-dose extrapolation problem. The proposed method is illustrated by application to a real data set. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - RISK assessment
KW - STATISTICS
KW - BINOMIAL distribution
KW - EVALUATION
KW - EXTRAPOLATION
KW - TERATOLOGY
KW - EMBRYOLOGY
KW - Beta-binomial distribution
KW - Low-dose extrapolation
KW - Teratology
KW - Weibull model.
N1 - Accession Number: 4606277; Chen, James J. 1; Kodell, Ralph L. 1; Affiliations: 1: Mathematical Statisticians, Biometry Staff, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079.; Issue Info: Dec89, Vol. 84 Issue 408, p966; Thesaurus Term: ESTIMATION theory; Thesaurus Term: RISK assessment; Thesaurus Term: STATISTICS; Subject Term: BINOMIAL distribution; Subject Term: EVALUATION; Subject Term: EXTRAPOLATION; Subject Term: TERATOLOGY; Subject Term: EMBRYOLOGY; Author-Supplied Keyword: Beta-binomial distribution; Author-Supplied Keyword: Low-dose extrapolation; Author-Supplied Keyword: Teratology; Author-Supplied Keyword: Weibull model.; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Bakfr, Edward L.
AU - Honchar, Patricia A.
AU - Fine, Lawrence J.
T1 - I. Surveillance in Occupational Illness and Injury: Concepts and Content.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 9
EP - 11
PB - American Public Health Association
SN - 00900036
AB - The article discusses the nature and significance of surveillance programs in occupational health. Occupational surveillance programs gather data and information which will provide an overview of a particular illness or injury. The complex needs of the field of occupational health is an obstacle in coming up with a single approach to surveillance. The improvements in data systems have helped determined innovative ways to utilize surveillance data to anticipate occupational diseases and complaints.
KW - Diseases
KW - Occupational diseases
KW - Industrial hygiene
KW - Occupational health services
KW - Medical care
KW - Medical research
KW - Health status indicators
KW - Clinical pathology
KW - Electronic health records
N1 - Accession Number: 4690735; Bakfr, Edward L. 1; Honchar, Patricia A. 2; Fine, Lawrence J. 3; Affiliations: 1: Deputy Director, National Institute for Occupational Safety and Health Centers for Disease Control; 2: Division of injury Epidemiology and Control Center for Environmental Health and Injury Control Centers for Disease Control; 3: Director Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health Centers for Disease Control; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p9; Thesaurus Term: Diseases; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Subject Term: Occupational health services; Subject Term: Medical care; Subject Term: Medical research; Subject Term: Health status indicators; Subject Term: Clinical pathology; Subject Term: Electronic health records; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ehrenberg, Richard L.
T1 - II. Use of Direct Surveys in the Surveillance of Occupational Illness and Injury.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 12
EP - 14
PB - American Public Health Association
SN - 00900036
AB - The application of direct surveys in the surveillance of occupational illness is discussed. Direct surveys collect information systematically through a specific sampling procedure which makes it an effective tool in gathering surveillance data for work-related injuries and ill health. Prevalent conditions can be determined by surveys through survey questioners or diagnostic tests. Direct surveys give pertinent data pertaining to the health status of an individual which will be useful in making precise health assessment
KW - Diseases -- Causes & theories of causation
KW - Pathology
KW - Industrial safety
KW - Health surveys
KW - Occupational health services
KW - Surveys
KW - Medical research
KW - Health status indicators
KW - Medical care surveys
N1 - Accession Number: 4690742; Ehrenberg, Richard L. 1; Affiliations: 1: Senior Medical Epidemiologist National institute for Occupational Safety and Health Centers for Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p12; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Pathology; Thesaurus Term: Industrial safety; Subject Term: Health surveys; Subject Term: Occupational health services; Subject Term: Surveys; Subject Term: Medical research; Subject Term: Health status indicators; Subject Term: Medical care surveys; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baker, Edward L
T1 - IV. Sentinel Event Notification System for Occupational Risks (SENSOR): The Concept.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 18
EP - 20
PB - American Public Health Association
SN - 00900036
AB - The Sentinel Event Notification System for Occupational Risk (SENSOR) is discussed. SENSOR was created to provide a framework for an active approach to six selected occupational disorders in the state-federal level. It is a provider-reporting system which aims to develop a uniform and prompt follow-up and surveillance for occupational illness and injury and thereby provide preventive measures for such illnesses. The advancement of SENSOR is cited as a step towards developing a comprehensive surveillance system for occupational diseases in the United States.
KW - Industrial hygiene
KW - Reporting of diseases
KW - Occupational health services
KW - Occupational diseases -- Reporting
KW - Occupational medicine
KW - Sentinel health events
KW - Health status indicators
KW - Public health surveillance
KW - Medical care
KW - United States
N1 - Accession Number: 4690765; Baker, Edward L 1; Affiliations: 1: Deputy Directors National institute for Occupational Safety and Health Centers for Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p18; Thesaurus Term: Industrial hygiene; Thesaurus Term: Reporting of diseases; Subject Term: Occupational health services; Subject Term: Occupational diseases -- Reporting; Subject Term: Occupational medicine; Subject Term: Sentinel health events; Subject Term: Health status indicators; Subject Term: Public health surveillance; Subject Term: Medical care; Subject: United States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matte, Thomas D.
AU - Baker, Edward L.
AU - Honchar, Patricia A.
T1 - V. The Selection and Definition of Targeted Work-Related Conditions for Surveillance under SENSOR.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 21
EP - 25
PB - American Public Health Association
SN - 00900036
AB - The article discusses the need to develop a list of work-related conditions which are relevant targets in state-based Sentinel Event Notification System for Occupational Risk (SENSOR). The availability of the list will focus the efforts of SENSOR projects, clarify reporting requirements for providers and promote state-based surveillance of occupational health problems of national significance. A list of prevalent diseases has benefited national surveillance priorities. Knowledge and experience from state health projects using SENSOR is a big help in establishing condition-specific surveillance strategies on a wider scope.
KW - Industrial safety
KW - Occupational diseases -- Reporting
KW - Occupational medicine
KW - Employee health promotion
KW - Health surveys
KW - Public health -- United States
KW - Cooperative Health Statistics System
KW - Work environment
KW - United States
N1 - Accession Number: 4690772; Matte, Thomas D. 1; Baker, Edward L. 2; Honchar, Patricia A. 3; Affiliations: 1: Medical Epidemiologist, Office of the Director, National Institute for Occupational Safety and Health Centers for Disease Control.; 2: National Institute for Occupational Safety and Health, Centers for Disease Control.; 3: Division of Injury Epidemiology and Control Center for Environmental Health and Injury Control Centers for Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p21; Thesaurus Term: Industrial safety; Subject Term: Occupational diseases -- Reporting; Subject Term: Occupational medicine; Subject Term: Employee health promotion; Subject Term: Health surveys; Subject Term: Public health -- United States; Subject Term: Cooperative Health Statistics System; Subject Term: Work environment; Subject: United States; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4690772&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sundin, David S.
AU - Frazier, Todd M.
T1 - VII. Hazard Surveillance at NIOSH.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 32
EP - 37
PB - American Public Health Association
SN - 00900036
AB - The article discusses the U.S. National Institute for Occupational Safety and Health's (NIOSH) efforts for hazard surveillance, providing a summary of major project initiatives concerning occupational safety following the passage of the Occupational Safety and Health Act of 1970. By virtue of the mandates of the occupational safety act the Task Force on Hazard and Disease was created and thus recommended that the NIOSH undertake a National Occupational Hazard Survey. The purpose of which is to determine the extent of exposure to occupational hazard in the workplace.
KW - Hazardous substances
KW - Health risk assessment
KW - Risk assessment
KW - Occupational diseases
KW - Threshold limit values (Industrial toxicology)
KW - Industrial safety -- Law & legislation
KW - Occupational medicine
KW - Employee health promotion
KW - Health surveys
KW - United States
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 4690789; Sundin, David S. 1; Frazier, Todd M. 2; Affiliations: 1: Section Chief. Hazard Section Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health Centers for Disease Control.; 2: Chief, Surveillance Branch Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p32; Thesaurus Term: Hazardous substances; Thesaurus Term: Health risk assessment; Thesaurus Term: Risk assessment; Thesaurus Term: Occupational diseases; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Industrial safety -- Law & legislation; Subject Term: Occupational medicine; Subject Term: Employee health promotion; Subject Term: Health surveys; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hanrahan, Lawrence P.
AU - Moll, Michael B.
T1 - VIII. Injury Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 38
EP - 45
PB - American Public Health Association
SN - 00900036
AB - Injury surveillance, the systematic collection, analysis and interpretation of data related to occupational injury including existing information systems for its implementation are discussed. The requirements of epidemiological surveillance and the limitations of the existing occupational injury databases along with areas like the need for detailed denominators, hazard monitoring, injury/event coding, reporting of health outcomes and fatality monitoring provide the basis for enhancement of injury surveillance in the United States.
KW - Industrial safety
KW - Risk assessment
KW - Industrial hygiene
KW - Occupational medicine
KW - Medical care
KW - Employee health promotion
KW - Health behavior
KW - Preventive health services
KW - Health risk assessment -- Research
KW - Occupational health services
KW - United States
N1 - Accession Number: 4690795; Hanrahan, Lawrence P. 1; Moll, Michael B. 2; Affiliations: 1: Epidemiologist Wiconsin Department of Health and, Social Services.; 2: Chief, Data Analysis Section Division of Safety Research National Institute for Occupational Safety and Health Centers for Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p38; Thesaurus Term: Industrial safety; Thesaurus Term: Risk assessment; Thesaurus Term: Industrial hygiene; Subject Term: Occupational medicine; Subject Term: Medical care; Subject Term: Employee health promotion; Subject Term: Health behavior; Subject Term: Preventive health services; Subject Term: Health risk assessment -- Research; Subject Term: Occupational health services; Subject: United States; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Melius, James M.
AU - Sestito, John P.
AU - Seligman, Paul J.
T1 - IX. Occupational Disease Surveillance with Existing Data Sources.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 46
EP - 52
PB - American Public Health Association
SN - 00900036
AB - The article discusses the utilization of existing data resources for surveillance of occupational disease. There are two aspects that limit the usefulness of existing data in occupational disease surveillance, which are, the conditions related to occupational exposure that must be included in the data system and the information on the occupation or employment setting of persons must also be included. Existing data sources can significantly contribute to the identification and control of occupational diseases in the United States.
KW - Occupational diseases
KW - Industrial hygiene
KW - Health risk assessment
KW - Diseases
KW - Disease management
KW - Occupational medicine
KW - Employee health promotion
KW - Medical care
KW - Medical statistics
KW - United States
N1 - Accession Number: 4690803; Melius, James M. 1; Sestito, John P. 2; Seligman, Paul J. 3; Affiliations: 1: Director, Division of Occupational Health and `Environmental Epidemiology New York State Department of Health; 2: Section Chief, Illness Effects Section Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health, Centers kw Disease Control; 3: Chiefs Medical Section Division of Surveillance, Hazard Evacuations and Field, Studies National Institute for Occupational Safety and Health Center for Disease Control.; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p46; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health risk assessment; Thesaurus Term: Diseases; Thesaurus Term: Disease management; Subject Term: Occupational medicine; Subject Term: Employee health promotion; Subject Term: Medical care; Subject Term: Medical statistics; Subject: United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bregman, Dennis J.
AU - Anderson, Kern E.
AU - Buffler, Patricia
AU - Salg, Joyce
T1 - X. Surveillance for Work-Related Adverse Reproductive Outcomes.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 53
EP - 57
PB - American Public Health Association
SN - 00900036
AB - Disorders in the reproductive system, which is one of the ten leading work-related disease listed by the U.S. National Institute for Occupational Safety and Health (NIOSH) is discussed. Two types of surveillance can be established to identify and control reproductive disorders in the workplace, which are, the surveillance for work-related disorders of reproduction and surveillance for physical and chemical hazards to reproductive health.The control of hazards prevents reproductive disorders as well which can be done through hazard surveillance. The strategies for surveillance of reproductive disorders need to be developed and innovative surveillance systems need to be established as well.
KW - Industrial hygiene
KW - Health risk assessment
KW - Hazardous substances
KW - Risk assessment
KW - Reproductive health
KW - Effect of chemicals on human reproduction
KW - Occupational health services
KW - Occupational medicine
KW - Work environment
KW - United States
N1 - Accession Number: 4690812; Bregman, Dennis J. 1; Anderson, Kern E. 2; Buffler, Patricia 3; Salg, Joyce 4; Affiliations: 1: Senior Math Statistician Division of Surveillance, Hazard Evaluations and Field Studies, National institute for Occupational Safety and Health Centers for Disease Control; 2: Public Health. Advisor Division of Surveillance, Hazard Evaluations and Field Studies National institute for Occupational Safety and Health Centers for Disease Control; 3: Director, Texas Educational Resources Center, University of Texas; 4: Epidemiologist Division of Surveillance, Hazard Evaluations arid Field Studies National Institute for Occupational Safety and Health Centers for Disease Control; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p53; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health risk assessment; Thesaurus Term: Hazardous substances; Thesaurus Term: Risk assessment; Subject Term: Reproductive health; Subject Term: Effect of chemicals on human reproduction; Subject Term: Occupational health services; Subject Term: Occupational medicine; Subject Term: Work environment; Subject: United States; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baker, Edward L.
T1 - XII. Challenges for the Future.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 61
EP - 63
PB - American Public Health Association
SN - 00900036
AB - The developments that the occupational health surveillance has been achieving and the programs carried out to acquire new accomplishments are discussed. State-based surveillance allowed a better analysis of occupational disorders which resulted to a timely disease prevention measures. The standardization of data collection, collaboration of federal agencies and the improvement of exposure surveillance are areas with significant role in improving the occupational health surveillance mechanism. The knowledge gained in these areas provides the foundation for an effective surveillance system in occupational health practice.
KW - Industrial hygiene
KW - Communication in industrial safety
KW - Occupational medicine
KW - Risk management in business
KW - Occupational health services
KW - Employee health promotion
KW - Medical care surveys
KW - Health facilities -- Administration
KW - United States
N1 - Accession Number: 4690825; Baker, Edward L. 1; Affiliations: 1: Deputy, Director National institute for Occupational Safety and Health Centers for Disease Control; Issue Info: Dec1989 Supplement, Vol. 79 Issue 12, p61; Thesaurus Term: Industrial hygiene; Thesaurus Term: Communication in industrial safety; Subject Term: Occupational medicine; Subject Term: Risk management in business; Subject Term: Occupational health services; Subject Term: Employee health promotion; Subject Term: Medical care surveys; Subject Term: Health facilities -- Administration; Subject: United States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - III. Development of a Standard Questionnaire for Occupational Health Research.
AU - Ehrenberg, Richard L.
AU - Sniezek, Joseph E.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
SP - 15
EP - 17
SN - 00900036
N1 - Accession Number: 4690749; Author: Ehrenberg, Richard L.: 1 Author: Sniezek, Joseph E.: 2 ; Author Affiliation: 1 Senior Medical Epidemiologist, National Institute for Occupational Safety and Health,Centers For Disease Control.: 2 Medical Epidemiologist Center for Environmental Health and Injury Control Centers for Disease Control.; No. of Pages: 3; Language: English; Publication Type: Article; Update Code: 20060929
N2 - The article discusses the development of a standard questionnaire used in direct surveys for occupational health research. A standardized method takes precedence in developing a questionnaire otherwise variations will occur in the study itself and other related surveys. The set of predetermined questions presented in a specific order provides for the standard of a questionnaire. A standard questionnaire is designed to collect information in a precise and consistent manner to reflect the exact interpretation of the data collected.
KW - *HEALTH surveys
KW - *HEALTH status indicators
KW - *OCCUPATIONAL health services
KW - *OCCUPATIONAL medicine
KW - QUESTIONNAIRES
KW - INDUSTRIAL hygiene
KW - RESEARCH -- Methodology
KW - QUESTIONS & answers
KW - STATISTICAL methods
KW - MEDICAL statistics
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DP - EBSCOhost
DB - s3h
ER -
TY - GEN
AU - Roscoe, Robert J.
AU - Steenland, Kyle
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12/22/
VL - 262
IS - 24
M3 - Letter
SP - 3404
EP - 3404
SN - 00987484
AB - Presents a letter to the editor of the December 22, 1989 issue of the 'Journal of the American Medical Association' about the classification of nonsmoking uranium miners who are indeed nonsmokers in the study that determined whether radon exposure is a risk factor for lung cancer.
KW - LUNGS -- Cancer
KW - URANIUM miners
KW - RADON
KW - LETTERS to the editor
N1 - Accession Number: 10983279; Roscoe, Robert J. 1; Steenland, Kyle 1; Source Information: 12/22/89-12/29/89, Vol. 262 Issue 24, p3404; Subject: LUNGS -- Cancer; Subject: URANIUM miners; Subject: RADON; Subject: LETTERS to the editor; Number of Pages: 4/9p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Greene, John C.
AU - Louis, Reginald
AU - Wycoff, Samuel J.
T1 - Preventive Dentistry.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12/22/
VL - 262
IS - 24
M3 - Article
SP - 3459
EP - 3463
SN - 00987484
AB - Provides background for the U.S. Preventive Services Task Force recommendations for interventions by physicians, nurses, and other clinicians, to prevent dental caries. Definition of dental caries; Preventive interventions such as fluorides, white fluoridation and dietary fluoride supplementation.
KW - DENTAL caries -- Prevention
KW - DENTAL care
KW - HEALTH
KW - UNITED States
N1 - Accession Number: 10983338; Greene, John C. 1; Louis, Reginald 2; Wycoff, Samuel J. 3; Source Information: 12/22/89-12/29/89, Vol. 262 Issue 24, p3459; Subject: DENTAL caries -- Prevention; Subject: DENTAL care; Subject: HEALTH; Geographic Terms: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Hamrell, M R
T1 - FDA perspective on computer assisted pharmacology/toxicology review
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1990///
VL - 24
IS - 3
M3 - Article
SP - 451
EP - 456
SN - 00928615
AB - This article describes the Food and Drug Administration's perspective on the use of the computer in the review of pharmacology/toxicology data. The development of the concept of a computer assisted pharmacology/toxicology review is studied. The discussions of a working group formed by the FDA and the Pharmaceutical Manufacturers Association to evaluate the use of computers in pharmacology are also reviewed. Mechanisms developed to facilitate the computerized review of data for the pharmacology submissions are also studied.
KW - Computer aided performance
KW - Computerization
KW - Drug information
KW - Federal government
N1 - Accession Number: ISTA2600118; Hamrell, M R 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: 1990, Vol. 24 Issue 3, p451; Note: Update Code: 2600; Author-Supplied Keyword: Computer aided performance; Author-Supplied Keyword: Computerization; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Gelberg, A
AU - Armstrong, G D
T1 - A study of the utilization of the FDA's adverse drug reaction database
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1990///
VL - 24
IS - 4
M3 - Article
SP - 785
EP - 794
SN - 00928615
AB - This paper is an overview of the uses of the Food and Drug Administration (FDA) Adverse Drug Reaction Reporting system. The procedures for signal generation, monitored adverse reactions, safety conferences, and recommendations are presented. Use of the on-line retrieval system, periodic reports, and Freedom-of-Information requests is discussed.
KW - DATABASES
KW - Biomedicine
KW - Drug information
KW - Federal government
N1 - Accession Number: ISTA2600649; Gelberg, A 1; Armstrong, G D; Affiliations: 1 : Center for Drug Evaluation and Research, FDA, Rockville, MD; Source Info: 1990, Vol. 24 Issue 4, p785; Note: Update Code: 2600; Subject Term: DATABASES; Author-Supplied Keyword: Biomedicine; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - CHAP
ID - 1990-98696-008
AN - 1990-98696-008
AU - Leon, Joel
T1 - Health care financing and service delivery.
T2 - Encyclopedia of social work: 1990 supplement, 18th ed.
Y1 - 1990///
SP - 135
EP - 158
CY - Silver Spring, MD, England
PB - National Association of Social Work
SN - 0-87101-178-6
N1 - Accession Number: 1990-98696-008. Partial author list: First Author & Affiliation: Leon, Joel; US Public Health Service, National Ctr for Health Services Research, National Medical Expenditure Survey, Senior Gerontologist, Rockville, MD, US. Release Date: 19900101. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. ISBN: 0-87101-178-6, Paperback. Language: English. Major Descriptor: Costs and Cost Analysis; Health Care Delivery; Health Care Services. Minor Descriptor: Health Insurance; Public Health Services; Social Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 24.
AB - the United States health care system has been changing dramatically / new types of providers and public and private health care programs are developing / both public and private payment mechanisms now are oriented toward cost containment / access to health services is becoming more divided along socioeconomic lines / more Americans are living longer / how does the present system differ from that of the past / how might the future look initiators of change [rising costs, health care as an economic sector, the aging population] / health care service delivery / private health insurance / public health care policies [Medicare, Medicaid, veteran programs] / long-term care / implications for social work (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - discusses current U.S. health care delivery system
KW - availability of health cost coverage for various populations
KW - & role of social work in health care service delivery
KW - 1990
KW - Costs and Cost Analysis
KW - Health Care Delivery
KW - Health Care Services
KW - Health Insurance
KW - Public Health Services
KW - Social Services
KW - 1990
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1990-98517-016
AN - 1990-98517-016
AU - Ginzburg, Harold M.
ED - Rosner, Richard
ED - Weinstock, Robert
ED - Rosner, Richard, (Ed)
ED - Weinstock, Robert, (Ed)
T1 - HIV infections and AIDS: Neuropsychiatric, psychosocial, and legal issues.
T2 - Ethical practice in psychiatry and the law.
T3 - Critical issues in American psychiatry and the law, Vol. 7
Y1 - 1990///
SP - 219
EP - 242
CY - New York, NY, US
PB - Plenum Press
SN - 0-306-43476-8
N1 - Accession Number: 1990-98517-016. Partial author list: First Author & Affiliation: Ginzburg, Harold M.; US Public Health Service, Health Resources & Services Administration, Bureau of Health Care Delivery & Assistance, Rockville, MD, US. Release Date: 19900101. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-306-43476-8, Hardcover. Language: English. Major Descriptor: AIDS; Professional Ethics. Minor Descriptor: Counseling; Legal Processes; Medical Diagnosis; Neuropsychiatry; Psychosocial Factors. Classification: Immunological Disorders (3291); Forensic Psychology & Legal Issues (4200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 24.
AB - reviews the neuropsychiatric and psychosocial aspects of HIV [human immunodeficiency virus] infection with a detailed discussion of the ethical and legal issues surrounding HIV counseling and testing, and presents several areas where the misuse of medical information may lead to discrimination neuropsychiatric complications of HIV infection / psychiatric complications of HIV infection (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - discusses ethical & legal issues regarding HIV testing & counseling
KW - neuropsychiatric
KW - psychiatric
KW - & psychosocial aspects
KW - 1990
KW - AIDS
KW - Professional Ethics
KW - Counseling
KW - Legal Processes
KW - Medical Diagnosis
KW - Neuropsychiatry
KW - Psychosocial Factors
KW - 1990
DO - 10.1007/978-1-4899-1663-1_16
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1990-98717-012
AN - 1990-98717-012
AU - Berman, Joan R. Saks
ED - Lerman, Hannah
ED - Porter, Natalie
ED - Lerman, Hannah, (Ed)
ED - Porter, Natalie, (Ed)
T1 - The problems of overlapping relationships in the political community.
T2 - Feminist ethics in psychotherapy.
Y1 - 1990///
SP - 106
EP - 110
CY - New York, NY, US
PB - Springer Publishing Co
SN - 0-8261-6290-8
N1 - Accession Number: 1990-98717-012. Partial author list: First Author & Affiliation: Berman, Joan R. Saks; Indian Health Service, Clinical Psychologist. Release Date: 19900101. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8261-6290-8, Hardcover. Language: English. Major Descriptor: Political Participation; Professional Ethics; Psychotherapeutic Processes. Minor Descriptor: Role Expectations. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 5.
AB - describes the particular problems facing the political activist who is also a therapist the therapist who is politically visible in her community is likely to experience difficulties with overlapping relationships presents us with examples of boundary overlaps that do not result in ethical violations or problems ethical problems with overlapping relationships can be avoided if the therapist is acutely aware of her own role expectations as a member and as a therapist lists cautions and questions to help therapists and clients develop the necessary awareness (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - explores psychotherapeutic processes in a clinical relationship in which therapist is politically active & ethics concerning professional boundaries
KW - 1990
KW - Political Participation
KW - Professional Ethics
KW - Psychotherapeutic Processes
KW - Role Expectations
KW - 1990
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1990-20134-001
AN - 1990-20134-001
AU - Dick, Robert B.
AU - Bhattacharya, Amit
AU - Shukla, Rakesh
T1 - Use of a computerized postural sway measurement system for neurobehavioral toxicology.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 1990/01//Jan-Feb, 1990
VL - 12
IS - 1
SP - 1
EP - 6
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
N1 - Accession Number: 1990-20134-001. PMID: 2314356 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Dick, Robert B.; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control, Cincinnati, OH, US. Release Date: 19900801. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Apparatus; Body Sway Testing; Computer Applications; Nervous System Disorders; Toxic Disorders. Minor Descriptor: Body Height; Body Weight; Posture. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 6. Issue Publication Date: Jan-Feb, 1990.
AB - Presents parametric results of postural sway indicators from data collected in a controlled laboratory study with 135 Ss (aged 18–32 yrs). The data were extracted from a performance test used in a study by R. B. Dick et al (1989) that involved short-duration exposures to acetone, methyl ethyl ketone, and a combination of both chemicals. In contrast with previous research (S. L. Sauter et al, 1980) the study identified some mild but significant effects of both height and weight on the sway measures used in the analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - height & weight & computerized apparatus
KW - postural sway measurement for neurobehavioral toxicology studies
KW - 18–32 yr olds
KW - 1990
KW - Apparatus
KW - Body Sway Testing
KW - Computer Applications
KW - Nervous System Disorders
KW - Toxic Disorders
KW - Body Height
KW - Body Weight
KW - Posture
KW - 1990
DO - 10.1016/0892-0362(90)90105-L
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Maizlish, Neli
AU - Fine, Lawrence J.
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/12/
VL - 263
IS - 2
M3 - Letter
SP - 237
EP - 237
SN - 00987484
AB - Replies to comments on an article on occupational diseases and carpal tunnel syndrome.
KW - OCCUPATIONAL diseases
KW - CARPAL tunnel syndrome
N1 - Accession Number: 10982665; Maizlish, Neli 1; Fine, Lawrence J. 2; Source Information: 1/12/90, Vol. 263 Issue 2, p237; Subject: OCCUPATIONAL diseases; Subject: CARPAL tunnel syndrome; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Greene, John C.
AU - Louie, Reginald
AU - Wycoff, Samuel J.
T1 - Preventive Dentistry.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/19/
VL - 263
IS - 3
M3 - Article
SP - 421
EP - 425
SN - 00987484
AB - Part II. Discusses U.S. Preventive Services Task Force's recommendations for physicians, nurses and other clinicians to prevent oral diseases and conditions. Periodontal diseases; Malocclusion; Trauma; Oral Cancer; Collaboration with the patient's dentist; Personal oral hygiene; Combined professional and professional care.
KW - PREVENTIVE dentistry
KW - PERIODONTAL disease
KW - MALOCCLUSION
KW - ORAL cancer
KW - UNITED States
N1 - Accession Number: 10981152; Greene, John C. 1; Louie, Reginald 2; Wycoff, Samuel J. 3; Source Information: 1/19/90, Vol. 263 Issue 3, p421; Subject: PREVENTIVE dentistry; Subject: PERIODONTAL disease; Subject: MALOCCLUSION; Subject: ORAL cancer; Geographic Terms: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Lawrence, Robert S.
AU - Mickalide, Angela D.
AU - Kamerow, Douglas B.
AU - Woof, Steven H.
AU - Lawrence, R S
AU - Mickalide, A D
AU - Kamerow, D B
AU - Woolf, S H
T1 - Report of the US Preventive Services Task Force.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/19/
VL - 263
IS - 3
M3 - commentary
SP - 436
EP - 437
SN - 00987484
AB - Discusses the 'Guide to Clinical Preventive Services: An Assessment of the Effectiveness of 169 Interventions,' by the U.S. Preventive Services Task Force. Importance of personal health practices; Shifting priorities in primary care; Designing medical practice to individual risks; Timing of preventive services; Changing role of patient.
KW - PREVENTIVE medicine
KW - MEDICAL care
KW - MEDICINE
KW - THERAPEUTICS
N1 - Accession Number: 10981095; Lawrence, Robert S. 1; Mickalide, Angela D. 2; Kamerow, Douglas B. 2; Woof, Steven H. 2; Lawrence, R S; Mickalide, A D; Kamerow, D B; Woolf, S H; Source Information: 1/19/90, Vol. 263 Issue 3, p436; Subject: PREVENTIVE medicine; Subject: MEDICAL care; Subject: MEDICINE; Subject: THERAPEUTICS; Number of Pages: 2p; Document Type: commentary
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Steenland, N. Kyle
AU - Thun, Michael J.
AU - Ferguson, C. William
AU - Port, Friedrich K.
T1 - Occupational and Other Exposures Associated with Male End-Stage Renal Disease: A Case/Control Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/02//
VL - 80
IS - 2
M3 - Article
SP - 153
EP - 157
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a case-control study of 325 men ages 30-69 who were diagnosed with end-stage renal disease (ESRD) between 1976 and 1984, and resided in four urban areas of Michigan in 1984. Cases were selected from the Michigan Kidney Registry and excluded men with diabetic, congenital, and obstructive nephropathies. Controls were selected by random-digit dialing and were pair-matched to cases for age, race, and area of residence. Telephone interviews were conducted with 69 percent of eligible cases and 79 percent of eligible controls. Risk of ESRD was significantly related to phenacetin or acetaminophen consumption (odds ratio(OR) = 2.66), moonshine consumption (OR = 2.43), a family history of renal disease (OR = 9.30); and regular occupational exposures to solvents (OR = 1.51) or silica (OR = 1.67). Particular occupational exposures with elevated risk were solvents used as cleaning agents and degreasers (OR = 2.50) silica exposure in foundries or brick factories (OR = 1.92), and silica exposure during sandblasting (OR = 3.83). Little or no trend of increased risk with duration of exposure was found for these occupational exposures, with the exception of silica in sandblasting. Limitations of these data include representativeness of cases, possible overreporting by cases, and misclassification of exposures inherent in self-reports. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Solvents
KW - Chronic kidney failure
KW - Kidney diseases
KW - Telephone surveys
KW - Phenacetin
KW - Acetaminophen
KW - Silica
KW - Metalworking industries
KW - Michigan (N.D.)
KW - United States
N1 - Accession Number: 4687174; Steenland, N. Kyle 1; Thun, Michael J. 1; Ferguson, C. William 2; Port, Friedrich K. 2; Affiliations: 1: National Institute for Occupational Safety and Health; 2: Michigan Kidney Registry; Issue Info: Feb1990, Vol. 80 Issue 2, p153; Thesaurus Term: Solvents; Subject Term: Chronic kidney failure; Subject Term: Kidney diseases; Subject Term: Telephone surveys; Subject Term: Phenacetin; Subject Term: Acetaminophen; Subject Term: Silica; Subject Term: Metalworking industries; Subject: Michigan (N.D.); Subject: United States; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schwartz, Joel
AU - Landrigan, Philip J.
AU - Baker Jr., Edward L.
AU - Orenstein, Walter A.
AU - von Lendern, Ian H.
T1 - Lead-Induced Anemia: Dose-Response Relationships and Evidence for a Threshold.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/02//
VL - 80
IS - 2
M3 - Article
SP - 165
EP - 168
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a cross-sectional epidemiologic study to assess the association between blood lead level and hematocrit in 579 one to five year-old children living near a primary lead smelter in 1974. Blood lead levels ranged from 0.53 to 7.91 µ mol/L (11 to 164 µ g/dl). To predict hematocrit as a function of blood lead level and age, we derived non-linear regression models and fit percentile curves. We used logistic regression to predict the probability of hematocrit values < 35 per ¢. We found a strong nonlinear, dose-response relationship between blood lead level and hematocrit. This relationship was influenced by age, but (in this age group) not by sex; the effect was strongest in youngest children. In one year-olds, the age group most severely affected, the risk of an hematocrit value below 35 percent was 2 percent above background at blood lead levels between 0.97 and 1.88 µ mol/L (20 and 39 µ g/dl), 18 percent above background at lead levels of 1.93 to 2.85 µ mol/L (40 to 59 µ g/dl), and 40 percent above background at lead levels of 2.9 µ mol/L (60 µ g/dl) and greater; background was defined as a blood lead level below 1.88 µ mol/L (20 µ g/dl). This effect appeared independent of iron deficiency. These findings suggest that blood lead levels close to the currently recommended limit value of 1.21 µ mol/L (25 µ g/dl) are associated with dose-related depression of hematocrit in young children. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology -- Research
KW - Dose-response relationship (Biochemistry)
KW - Age distribution (Demography)
KW - Blood diseases
KW - Hematocrit
KW - Logistic regression analysis
KW - Gender
KW - Iron deficiency diseases
KW - Examination of the blood
N1 - Accession Number: 4687257; Schwartz, Joel 1; Landrigan, Philip J. 2; Baker Jr., Edward L. 3; Orenstein, Walter A. 4; von Lendern, Ian H. 5; Affiliations: 1: US Environmental Protection Agency, Washington, DC; 2: Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029-6574; 3: Deputy Director, National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia; 4: Director, Division of Immunization, Center for Prevention Services, CDC, Atlanta; 5: TerraGraphics Environmental Engineering, Moscow, Idaho; Issue Info: Feb1990, Vol. 80 Issue 2, p165; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: Dose-response relationship (Biochemistry); Subject Term: Age distribution (Demography); Subject Term: Blood diseases; Subject Term: Hematocrit; Subject Term: Logistic regression analysis; Subject Term: Gender; Subject Term: Iron deficiency diseases; Subject Term: Examination of the blood; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brito, G.
AU - Díaz, C.
AU - Galindo, L.
AU - Hardisson, A.
AU - Santiago, D.
AU - García Montelongo, F.
T1 - Levels of metals in canned meat products: Intermetallic correlations.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1990/02//
VL - 44
IS - 2
M3 - Article
SP - 309
EP - 316
SN - 00074861
AB - The article presents a study on the metal levels in various canned meat products, such as preserved ham, shoulder pork and lunch pork. The study conducted the experiments with different methods such as flame atomic-absorption spectrophotometry, binary statistical analysis and computer simulation. Results show no significant differences found among the samples. It concludes that the heavy metal content of the products came from the products, and not from its containers.
KW - Meat -- Contamination
KW - RESEARCH
KW - Computer simulation
KW - Heavy metals
KW - Atomic absorption spectroscopy
KW - Quantitative research
KW - Canned meat
KW - Meat -- Packaging
N1 - Accession Number: 70789588; Brito, G. 1; Díaz, C. 2; Galindo, L. 2; Hardisson, A. 2; Santiago, D. 3; García Montelongo, F. 2; Affiliations: 1: Canary Islands Public Health Service, 38004 Santa Cruz de Tenerife Spain; 2: Department of Analytical Chemistry, University of La Laguna, 38204 La Laguna Spain; 3: Department of Pharmacology and Toxicology, University of Córdoba, 14005 Córdoba Spain; Issue Info: Feb1990, Vol. 44 Issue 2, p309; Thesaurus Term: Meat -- Contamination; Thesaurus Term: RESEARCH; Thesaurus Term: Computer simulation; Subject Term: Heavy metals; Subject Term: Atomic absorption spectroscopy; Subject Term: Quantitative research; Subject Term: Canned meat; Subject Term: Meat -- Packaging; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; NAICS/Industry Codes: 311422 Specialty Canning; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF01700152
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hisnanick, John J.
AU - Kymn, Kern O.
AD - Indian Health Service, Tuscon
AD - WV U
T1 - The Evaluation of the U.S. Manufacturing Sector Using Multifactor Inputs of Capital, Labor, Energy and Real Cash Balances
JO - Rivista Internazionale di Scienze Economiche e Commerciali
JF - Rivista Internazionale di Scienze Economiche e Commerciali
Y1 - 1990/02//
VL - 37
IS - 2
SP - 149
EP - 162
SN - 00356751
N1 - Accession Number: 0235981; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199012
N2 - The paper investigates the validity of the inclusion of the inputs money and energy into the production function of the U.S. manufacturing sector for 1958-81. Considering that both the factor inputs and the output are aggregated using the Divisia indexing process, one cannot justify that the underlying production function exhibits constant returns to scale. The paper empirically tests the assumption of constant returns to scale and shows that this assumption is statistically valid. Regarding separability, the individual inputs energy and money have been shown to be globally separable and when aggregated they are both locally and globally separable from the capital and labor aggregation. Therefore, through statistical validation, the conclusion is that money and energy are essential inputs in the production process.
KW - Industry Studies Manufacturing General 6310
KW - Productivity Studies: Labor, Capital, and Total Factor 8250
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Anderson, D.
AU - Kulis, D.
AU - Sullivan, J.
AU - Hall, S.
AU - Lee, C.
T1 - Dynamics and physiology of saxitoxin production by the dinoflagellates Alexandrium spp.
JO - Marine Biology
JF - Marine Biology
Y1 - 1990/02/15/
VL - 104
IS - 3
M3 - Article
SP - 511
EP - 524
SN - 00253162
AB - Toxin content (fmol cell) and a suite of elemental and macromolecular variables were measured in batch cultures of the dinoflagellates Alexandrium fundyense, A. tamarense and Alexandrium sp. from the southern New England region, USA. A different perspective was provided by semicontinuous cultures which revealed sustained, steady-state physiological adaptations by cells to N and P limitation. Two types of variability were investigated. In batch culture, changes in nutrient availability with time caused growth stage variability in toxin content, which often peaked in mid-exponential growth. A second type of variability that could be superimposed on growth stage differences is best exemplified by the high toxin content of cells grown at suboptimal temperatures. Calculations of the net rate of toxin production ( R; fmol cell d) for these different culture treatments and modes made it possible to separate the dynamics of toxin production from cell division. Over a wide range of growth rates, cells produced toxin at rates approximating those needed to replace 'losses' to daughter cells during division. The exception to this direct proportionality was with P limitation, which was associated with a dramatic increase in the rate of toxin production as cells stopped dividing due to nutrient limitation in batch culture. Growth stage variability in batch culture thus reflects small imbalances (generally within a factor of two) between the specific rates of toxin production and cell division. N limitation and CO depletion both affect pathways involved in toxin synthesis before those needed for cell division; P limitation does the opposite. The patterns of toxin accumulation were the same as for major cellular metabolites or elemental pools. The highest rates of toxin production appear to result from an increased availability of arginine (Arg) within the cell, due to either a lack of competition for this amino acid from pathways involved in cell division or to increased de novo synthesis. There were no significant changes in toxin content with either acclimated growth at elevated salinity, or with short term increases or decreases of salinity. These results demonstrate that toxin production is a complex process which, under some conditions, is closely coupled to growth rate; under other conditions, these processes are completely uncoupled. Explanations for the observed variability probably relate to pool sizes of important metabolites and to the differential response of key biochemical reactions to these pool sizes and to environmental conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Marine Biology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Saxitoxin
KW - Dinoflagellates
KW - Toxins
KW - Cell division (Biology)
KW - Blastomeres
N1 - Accession Number: 71122527; Anderson, D. 1; Kulis, D. 1; Sullivan, J. 2; Hall, S. 3; Lee, C. 4; Affiliations: 1: Biology Department, Woods Hole Oceanographic Institution, 02543 Woods Hole USA; 2: Varian Associates, Inc., 2700 Mitchell Drive 94598 Walnut Creek USA; 3: U.S. Food and Drug Administration, Natural Food Toxicants Group, HFF-454, 200 C Street S.W. 20204 Washington, D.C. USA; 4: Marine Sciences Research Center, State University of New York at Stony Brook, 11794 Stony Brook USA; Issue Info: 1990, Vol. 104 Issue 3, p511; Thesaurus Term: Saxitoxin; Thesaurus Term: Dinoflagellates; Thesaurus Term: Toxins; Thesaurus Term: Cell division (Biology); Subject Term: Blastomeres; Number of Pages: 14p; Document Type: Article
L3 - 10.1007/BF01314358
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Smith, Suzanne M.
AU - Colwell, Lewis S.
AU - Sniezek, Joseph E.
T1 - An Evaluation of External Cause-of-Injury Codes Using Hospital Records from the Indian Health Service, 1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Article
SP - 279
EP - 281
PB - American Public Health Association
SN - 00900036
AB - Abstract: To evaluate the usefulness of International Classification of Diseases external cause-of-injury and poisoning codes (E codes) for public health surveillance of nonfatal injuries, we analyzed E codes from Indian Health Service (IHS) hospital records. E codes for unknown or unspecified causes were used for 25 percent of records. At two hospitals, 63 percent of E codes assigned by independent coders agreed; another 18 percent matched on general cause-of-injury groups. With uniform guidelines and increased training, E coding could provide a valuable, cost-effective method of quantifying and characterizing severe, nonfatal injuries. (Am J Public Health 1990; 80:279-281.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nosology
KW - Wounds & injuries
KW - Poisoning
KW - Cost effectiveness
KW - Epidemiology
KW - Public health surveillance
KW - Hospital records
KW - Guidelines
KW - Training
N1 - Accession Number: 4691632; Smith, Suzanne M. 1; Colwell, Lewis S. 2; Sniezek, Joseph E. 3; Affiliations: 1: Medical Epidemiologist, Program Surveillence Section, Division of Injury Epidemiology and Control, Center for Environmental Health and Injury Control, Mail Stop F36, Centers for Disease Control, Atlanta, GA 30333; 2: Medical Epidemiologist, Division of Injury Epidemiology and Control, CDC, Atlanta; 3: Environmental Consultant, Indian Health Services, US Public Health Service, Atlanta; Issue Info: Mar1990, Vol. 80 Issue 3, p279; Thesaurus Term: Nosology; Thesaurus Term: Wounds & injuries; Thesaurus Term: Poisoning; Thesaurus Term: Cost effectiveness; Thesaurus Term: Epidemiology; Subject Term: Public health surveillance; Subject Term: Hospital records; Subject Term: Guidelines; Subject Term: Training; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Newman, Jeffrey M.
AU - Marfin, Anthony A.
AU - Eggers, Paul W.
AU - Helgerson, Steven D.
T1 - End State Renal Disease among Native Americans, 1983-86.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Article
SP - 318
EP - 319
PB - American Public Health Association
SN - 00900036
AB - Abstract: We used data reported to Medicare from 1983 through 1986 to determine the incidence of end-stage renal disease (ESRD) among Native Americans and Whites in the United States. The 1,075 Native American cases represented an annual incidence, ageadjusted to the White population, of 269 per million, 2.8 times the rate for Whites. Fifty-six percent of Native American cases and 27 percent of the White cases were attributed to diabetes, indicating that ESRD is a major problem. Diabetes control provides the greatest opportunity for prevention. (Am J Public Health 1990; 80:318-319.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Chronic kidney failure
KW - Native Americans
KW - Caucasian race
KW - Medicare
KW - Medical policy
KW - Diabetes
KW - National health insurance
KW - Kidney diseases
N1 - Accession Number: 4692067; Newman, Jeffrey M. 1; Marfin, Anthony A. 2; Eggers, Paul W. 3; Helgerson, Steven D. 2; Affiliations: 1: Medical Epidemiologist, Division of Diabetes Translation (E08), Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, GA 30333; 2: Office of Health PROGRAM Research and Development, Indian Health Service, Tucson, AZ.; 3: Office of Research, Health Care Financing Administration, Baltimore, MD.; Issue Info: Mar1990, Vol. 80 Issue 3, p318; Thesaurus Term: Public health; Subject Term: Chronic kidney failure; Subject Term: Native Americans; Subject Term: Caucasian race; Subject Term: Medicare; Subject Term: Medical policy; Subject Term: Diabetes; Subject Term: National health insurance; Subject Term: Kidney diseases; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Martyny, John
AU - Valway, Sarah
AU - Mangione, Ellen
T1 - Lead Exposure in Indoor Firing Ranges.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Letter
SP - 354
EP - 354
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Lead Absorption in Indoor Firing Range Users," by S.E. Valway et al in the August 1989 issue.
KW - Lead
KW - Letters to the editor
N1 - Accession Number: 21088533; Martyny, John 1; Valway, Sarah 1; Mangione, Ellen 1; Affiliations: 1: Indian Health Service Diabetes Program, 2401 12th Street, NW, Albuquerque, NM 87102; Issue Info: Mar1990, Vol. 80 Issue 3, p354; Thesaurus Term: Lead; Subject Term: Letters to the editor; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HOLLINGWORTH, THOMAS A.
AU - WEKELL, MARLEEN M.
AU - SULLIVAN, JOHN J.
AU - TORKELSON, JAMES D.
AU - THROM, HAROLD R.
T1 - Chemical Indicators of Decomposition for Raw Surimi and Flaked Artificial Crab.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1990/03//
VL - 55
IS - 2
M3 - Article
SP - 349
EP - 352
SN - 00221147
AB - BSTRACT Raw surimi and a surimi-derived flaked artificial crab were stored at 4°C, 10°C and 22°C until advanced decomposition occurred. The raw surimi and the flaked artificial crab remained at an acceptable level of quality based on sensory analysis for approximately 2-4 days and 6-8 days, respectively, when stored at 10°C. Both products were of acceptable quality for at least 13 days when stored at 4°C. The potentials of total volatile acids (TVA) and total volatile bases (TVB) determined by flow injection analysis, ethanol determined by head-space gas chromatography and the amines, cadaverine, putrescine, and histamine all determined by high performance liquid chromatography, were evaluated as chemical indicators of decomposition for those products. TVA and TVB appeared to have the most potential as indicators of decomposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Decomposition (Chemistry)
KW - Crabs
KW - Gas chromatography
KW - Amines
KW - Surimi
KW - Food -- Composition
KW - Food -- Analysis
KW - Histamine
N1 - Accession Number: 63140239; HOLLINGWORTH, THOMAS A. 1; WEKELL, MARLEEN M. 1; SULLIVAN, JOHN J. 2; TORKELSON, JAMES D. 3; THROM, HAROLD R. 3; Affiliations: 1: Authors Hollingworth and Wekell are with the Seafood Products Research Center, Food and Drug Administration, Bothell, WA 98041-3012.; 2: Author Sullivan, formerly with the Seafood Products Research Center, is now with Varian Associates, Walnut Creek, CA 94598.; 3: Authors Torkelson and Throm are with the Seattle District Laboratory, Food and Drug Administration, Bothell, WA 98041-3012.; Issue Info: Mar1990, Vol. 55 Issue 2, p349; Thesaurus Term: Decomposition (Chemistry); Thesaurus Term: Crabs; Thesaurus Term: Gas chromatography; Thesaurus Term: Amines; Subject Term: Surimi; Subject Term: Food -- Composition; Subject Term: Food -- Analysis; Subject Term: Histamine; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1365-2621.1990.tb06760.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1990-30801-001
AN - 1990-30801-001
AU - Zitzow, Darryl
T1 - A comparison of the time Ojibway adolescents spent with parents/elders in the 1930s and 1980s.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1990///Spr 1990
VL - 3
IS - 3
SP - 7
EP - 16
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1990-30801-001. PMID: 2096945 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Zitzow, Darryl; White Earth Clinic, PHS Indian Health Service, MN, US. Release Date: 19901201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Family Relations; Interpersonal Interaction; Time. Classification: Marriage & Family (2950). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 10. Issue Publication Date: Spr 1990.
AB - Compared quantity and quality of family time spent with parents/elders by 94 American Indian Ojibway adolescents (aged 12–18 yrs) in the 1980s to 141 Ojibway adults (aged 55–70 yrs) who were adolescents in the 1930s. 1980s adolescents spent an average of 12.5 hrs per wk with parents/elders compared with 62 hrs per wk shown by respondents who were adolescents in the 1930s. The 1980s adolescents reported significantly more adult substance use and family abuse within their homes and showed significantly less favorable well-being responses than 1930s adolescents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quantity of time spent with parents & elders & amount of family dysfunction during adolescence
KW - Ojibway 12–18 vs 55–70 yr olds
KW - 1930s vs 1980s
KW - 1990
KW - American Indians
KW - Family Relations
KW - Interpersonal Interaction
KW - Time
KW - 1990
DO - 10.5820/aian.0303.1990.7
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kurt, Thomas L.
AU - Kurt, T L
T1 - The (internal) dangers of acrylic fingernails.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/04/25/
VL - 263
IS - 16
M3 - letter
SP - 2181
EP - 2181
SN - 00987484
AB - Presents a letter to the editor in the April 25, 1990 issue of the 'Journal of the American Medical Association,' about examples of the dangers of acrylic fingernails including cyanide poisoning of children after the ingestion of sculpted nail remover solvents, which contain acetonitrile and other nitriles.
KW - POISONING
KW - CHEMICALS
KW - ACETONITRILE
KW - NITRILES
KW - LETTERS to the editor
KW - COSMETICS
KW - METHEMOGLOBINEMIA
KW - NAILS (Anatomy)
N1 - Accession Number: 11020785; Kurt, Thomas L. 1; Kurt, T L; Source Information: 4/25/90, Vol. 263 Issue 16, p2181; Subject: POISONING; Subject: CHEMICALS; Subject: ACETONITRILE; Subject: NITRILES; Subject: LETTERS to the editor; Subject: COSMETICS; Subject: METHEMOGLOBINEMIA; Subject: NAILS (Anatomy); Number of Pages: 1p; Document Type: letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Kennedy, Dianne L.
AU - Gross, Thomas P.
T1 - Prescribed Use of Cholesterol-Lowering Drugs in the United States, 1978 Through 1988.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/04/25/
VL - 263
IS - 16
M3 - Article
SP - 2185
EP - 2188
SN - 00987484
AB - Examines trends in outpatient use of cholesterol-lowering drugs in the U.S. from 1978 through 1988. Estimated prescribed drugs dispensed by retail pharmacies; Introduction of the drugs gemfibrozil and lovastatin; Estimated number of Americans with high cholesterol levels; Top-selling drugs.
KW - ANTICHOLESTEREMIC agents
KW - PHARMACEUTICAL industry
KW - DRUGSTORES
KW - UNITED States
N1 - Accession Number: 11020814; Wysowski, Diane K. 1; Kennedy, Dianne L. 1; Gross, Thomas P. 1; Source Information: 4/25/90, Vol. 263 Issue 16, p2185; Subject: ANTICHOLESTEREMIC agents; Subject: PHARMACEUTICAL industry; Subject: DRUGSTORES; Geographic Terms: UNITED States; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Umehara, H.
AU - Bloom, E. T.
T1 - The IL-2 receptor beta subunit is absolutely required for mediating the IL-2-induced activation of NK activity and proliferative activity of human large granular lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1990/05//
VL - 70
IS - 1
M3 - Article
SP - 111
EP - 115
SN - 00192805
AB - TU27 monoclonal antibody reacts with the cellular receptor to the beta subunit of the interleukin-2 receptor (IL-2R) (p70–75). This reagent has been utilized to demonstrate directly that the IL-2Rβ is the IL-2-binding protein that mediates the activation of large granular lymphocytes (LGL) to proliferate and increase cytolytic activity in response to IL-2. The results presented here show that (i) the frequency of TU27+ cells paralleled the frequency of CD16+ (Leu-11+) cells; (ii) TU27 completely abrogated the proliferative response of LGL to IL-2, while GL439, an anti-IL-2Rα (anti-Tac) reagent, had a much smaller effect, and the effect of the two together was no different from the effect of TU27 alone; (iii) TU27 abolished the IL-2-induced activation of natural killer (NK) activity and inhibited the development of LAK activity, while GL439 had no effect; and (iv) TU27 also inhibited naive NK activity. Therefore, these data clearly show that the IL-2-IL-2Rβ interaction is responsible, and probably completely so, for the proliferative and cytolytic-promoting effects of IL-2 on LGL. In addition, they also suggest a role for this interaction in autocrine effects on native NK activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - INTERLEUKIN-2
KW - BIOLOGICAL response modifiers
KW - IMMUNE response -- Regulation
KW - IMMUNOLOGY
N1 - Accession Number: 13356864; Umehara, H. 1,2; Bloom, E. T. 1,2; Source Information: May90, Vol. 70 Issue 1, p111; Subject: MONOCLONAL antibodies; Subject: IMMUNOGLOBULINS; Subject: INTERLEUKIN-2; Subject: BIOLOGICAL response modifiers; Subject: IMMUNE response -- Regulation; Subject: IMMUNOLOGY; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Steenland, N. Kyle
AU - Silverman, Debra T.
AU - Hornung, Richard W.
T1 - Case-Control Study of Lung Cancer and Truck Driving in the Teamsters Union.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/06//
VL - 80
IS - 6
M3 - Article
SP - 670
EP - 674
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a case-control study of lung cancer deaths in the Teamsters Union to compare the risk of different occupations within the teamsters, after controlling for smoking and other confounders. Occupations with no presumed exposure to diesel fumes were used as the nonexposed group. The study population consisted of 996 cases and 1,085 controls who had died in 1982-83 after applying for pensions. Next of kin provided information on smoking, work history, and other potential confounders. Work history data were also obtained from the Teamsters Union. While no single job category had a significant excess risk compared to the non-exposed group, certain sub-groups were elevated. The odds ratio for those with long-term employment as long-haul truckers after 1959 (an approximate date for the introduction of diesel engines) was 1.55 (95% CI: 0.97, 2.47). Long-term drivers of primarily diesel trucks had an odds ratio of 1.89 (95% CI: 1.04, 3.42). Overall, our results suggest that diesel truck drivers have an excess risk of lung cancer compared to other teamsters in jobs outside the trucking industry. However, our findings were not uniformly consistent and our data have many limitations, the most important of which is the lack of data on exposure to diesel fumes. (Am J Public Health 1990; 80:670-674.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Smoking
KW - Diesel motor exhaust gas
KW - Occupational diseases
KW - Public health
KW - Lungs -- Cancer
KW - Transport workers
KW - Pensions
KW - International Brotherhood of Teamsters
N1 - Accession Number: 4684898; Steenland, N. Kyle 1; Silverman, Debra T. 2; Hornung, Richard W. 1; Affiliations: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories. 4676 Columbia Parkway. Cincinnati, OH; 2: National Cancer Institute; Issue Info: Jun90, Vol. 80 Issue 6, p670; Thesaurus Term: Smoking; Thesaurus Term: Diesel motor exhaust gas; Thesaurus Term: Occupational diseases; Thesaurus Term: Public health; Subject Term: Lungs -- Cancer; Subject Term: Transport workers; Subject Term: Pensions ; Company/Entity: International Brotherhood of Teamsters; NAICS/Industry Codes: 526111 Trusteed pension funds; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1992-36322-001
AN - 1992-36322-001
AU - Schantz, Peter M.
T1 - Preventing potential health hazards incidental to the use of pets in therapy.
JF - Anthrozoös
JO - Anthrozoös
JA - Anthrozoos
Y1 - 1990///Sum 1990
VL - 4
IS - 1
SP - 14
EP - 23
CY - US
PB - Purdue University Press
SN - 0892-7936
SN - 1753-0377
N1 - Accession Number: 1992-36322-001. Other Journal Title: Journal of the Delta Society. Partial author list: First Author & Affiliation: Schantz, Peter M.; US Dept of Health & Human Services, Ctrs for Disease Control Public Health Service Ctr for Infectious Diseases Parasitic Diseases Div, Atlanta, GA, US. Other Publishers: Berg Publishers; Bloomsbury Publishing; Taylor & Francis. Release Date: 19921001. Correction Date: 20151026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Allergic Disorders; Infectious Disorders; Pets; Prevention; Treatment. Classification: Specialized Interventions (3350). Population: Human (10). Page Count: 10. Issue Publication Date: Sum 1990.
AB - Discusses the nature and incidence of 3 categories of pet-associated hazards (animal bites, infectious diseases, and animal allergies) in institutional settings, where pet-facilitated therapy is used with physically and psychologically handicapped patients. These risks can be minimized by carefully selecting the appropriate species and temperament of the pet, providing adequate veterinary care, and educating staff and patients about the potential dangers and how to avoid them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention of animal bites & allergies & infectious diseases in pet therapy
KW - 1990
KW - Allergic Disorders
KW - Infectious Disorders
KW - Pets
KW - Prevention
KW - Treatment
KW - 1990
DO - 10.2752/089279391787057369
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hall, Roberta L.
AU - Wilder, Doni
AU - Bodenroeder, Pamela
AU - Hess, Michael
T1 - Assessment of AIDS Knowledge, Attitudes, Behaviors, and Risk Level of Northwestern American Indians.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/07//
VL - 80
IS - 7
M3 - Article
SP - 875
EP - 877
PB - American Public Health Association
SN - 00900036
AB - A survey was made of 710 American Indians of Oregon, Washington, and Idaho to assess the population's knowledge, attitudes, and behaviors in respect to acquired immunodeficiency syndrome (AIDS), to estimate the population's risk, and to plan strategies to reduce it. In contrast to 3 percent of the general population, this study found 10.6 percent of male and 6.4 percent of female Pacific Northwestern American Indians in groups considered at high risk for AIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - Health risk assessment
KW - Health behavior
KW - Attitudes toward health
KW - Native Americans
KW - Oregon
KW - Washington (State)
KW - Idaho
KW - United States
N1 - Accession Number: 9102111383; Hall, Roberta L. 1; Wilder, Doni 2; Bodenroeder, Pamela 3; Hess, Michael 4; Affiliations: 1: Professor, Department of Anthropology, Oregon State University, Waldo Hall 238, Corvallis, OR 97331-6403; 2: NW Portland Area Indian Health Board; 3: Survey Research Center, Oregon State University, Corvallis; 4: Indian Health Service, Portland; Issue Info: Jul1990, Vol. 80 Issue 7, p875; Thesaurus Term: AIDS (Disease); Thesaurus Term: Health risk assessment; Subject Term: Health behavior; Subject Term: Attitudes toward health; Subject Term: Native Americans; Subject: Oregon; Subject: Washington (State); Subject: Idaho; Subject: United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Schleifer, L M
AU - Smith, R J
T1 - Ergonomic predictors of visual system complaints in VDT data entry work
JO - Behaviour & Information Technology
JF - Behaviour & Information Technology
Y1 - 1990/07//
VL - 9
IS - 4
M3 - Article
SP - 273
EP - 282
SN - 0144929X
AB - This paper investigates the relationship between ergonomic demands and visual system complaints among video-display-terminal operators at two state agencies. The authors assess ergonomic factors suspected of posing visual demands at 40 data-entry workstations. The results of a survey on somatic discomfort, demographic and personal characteristics of operators in two agencies is also discussed. Regression analyses also indicate that personal factors, such as age and use of corrective eyewear, account for little of the variance in measures of visual system complaints.
KW - HUMAN engineering
KW - FORECASTING
KW - Eyes
KW - Health
N1 - Accession Number: ISTA2503814; Schleifer, L M 1; Smith, R J; Affiliations: 1 : National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: Jul 1990, Vol. 9 Issue 4, p273; Note: Update Code: 2500; Subject Term: HUMAN engineering; Subject Term: FORECASTING; Author-Supplied Keyword: Eyes; Author-Supplied Keyword: Health; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Schaapveld, K.
T1 - A. J. Silman and S. P. A. Allwright (Eds)., Elimination or reduction of diseases? Opportunities for health service action in Europe. Oxford: Oxford University Press, 1988. Price (UK) £30.00.
JO - International Journal of Health Planning & Management
JF - International Journal of Health Planning & Management
Y1 - 1990/07//
VL - 5
IS - 3
M3 - Article
SP - 229
EP - 230
SN - 07496753
N1 - Accession Number: 64206302; Schaapveld, K. 1; Affiliations: 1: Head, Department of Infectious Diseases and Hygiene, Rotterdam Public Health Service, The Netherlands; Issue Info: Jul1990, Vol. 5 Issue 3, p229; Number of Pages: 2p; Document Type: Article
L3 - 10.1002/hpm.4740050309
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Backinger, Cathy L.
T1 - World health organization, Smokeless tobacco control; Report of a WHO study group. Technical Report Series, No. 773, Geneva: World Health Organization, 1988, 81 pp. Price (Sw. fr.) 11; (US) £8.80.
JO - International Journal of Health Planning & Management
JF - International Journal of Health Planning & Management
Y1 - 1990/07//
VL - 5
IS - 3
M3 - Article
SP - 230
EP - 231
SN - 07496753
N1 - Accession Number: 64206298; Backinger, Cathy L. 1; Affiliations: 1: Public Health Analyst, Food and Drug Administration, USA; Issue Info: Jul1990, Vol. 5 Issue 3, p230; Number of Pages: 2p; Document Type: Article
L3 - 10.1002/hpm.4740050310
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sudre, P.
AU - Serdula, M.
AU - Binkin, N.
AU - Staehling, N.
AU - Kramer, M.
T1 - Child fostering, health and nutritional status: The experience of Swaziland.
JO - Ecology of Food & Nutrition
JF - Ecology of Food & Nutrition
Y1 - 1990/08//
VL - 24
IS - 3
M3 - Article
SP - 181
EP - 188
SN - 03670244
AB - In developing countries, as women increasingly engage in economic activity away from home, foster care of children appears to have become more common. Because fostered children may receive less attention, it has been hypothesized that fostering may adversely affect nutritional status and health. A nutrition survey conducted in 1983 in rural Swaziland on 4683 children < 6 years of age allowed an examination of fostering practices and their association with health services utilization and nutritional status. Fostered children are defined as those whose biologic mother is not a member of the homestead or is absent more than 50% of the time. Fostering increases with age. Guardians are older than biologic mothers and have a lower literacy rate. Fostered children are less likely than non‐fostered children to be fully immunized. Fostered and non‐fostered children have similar histories of MCH clinic attendance. After adjustment for socio‐demographic factors, nutritional status of fostered and non‐fostered children does not differ significantly. This study shows a high prevalence of fostering, but does not support the hypothesis of an association between fostering and poorer health as measured by nutritional status. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Ecology of Food & Nutrition is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75864470; Sudre, P. 1; Serdula, M. 1; Binkin, N. 1; Staehling, N. 1; Kramer, M. 2; Affiliations: 1: Division of Nutrition, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, G A, USA; 2: Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada; Issue Info: Aug1990, Vol. 24 Issue 3, p181; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/03670244.1990.9991136
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Puri, R.K.
AU - Finbloom, D.S.
AU - Leland, P.
AU - Mostowski, H.
AU - Siegel, J.P.
T1 - Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2.
JO - Immunology
JF - Immunology
Y1 - 1990/08//
VL - 70
IS - 4
M3 - Article
SP - 492
EP - 497
SN - 00192805
AB - Since interleukin-2 (IL-2) and IL-4 act in concert to support the development of cytotoxic T lymphocytes (CTL) and the generation of antigen-specific tumour infiltrating lymphocytes (TIL), we investigated the interaction of these cytokines with an established TIL line. TIL proliferated in an additive fashion in response to suboptimal concentrations of IL-2 and various concentrations of IL-4. TIL possessed high-affinity IL-4 receptors whether cultured in recombinant IL-2 (rIL-2) or rIL-4, but cells cultured in rIL-2 had higher numbers of IL-4 receptors than cells cultured in rIL-4. When TIL were cultured in increasing concentrations of rIL-2, a dose-dependent enhancement in IL4 receptor number was observed. The maximum induction of IL-4 receptor expression was achieved by 4 hr of incubation with rIL-2 and was completely blocked by cycloheximide. Other cytokines, such as rIL-1, recombinant turnout necrosis factor (rTNF), recombinant interferon-alpha (rIFN-α) and rIFN-γ, had no effect on IL-4 receptor number, rIL-2 also up-regulated IL-4 receptors on CTLL-2, a murine CTL line. These data indicate that high-affinity IL-4 receptors exist on murine TIL and they can be up-regulated by IL-2. Our observation that IL-2 up-regulates IL-4 receptor may help explain the additive effects of these lymphokines on the proliferation of TI L and other cell lines. It may also help explain their co-operative effects on the generation of antigen-specific TIL and the differentiation of CTL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - TUMORS
KW - INTERLEUKIN-2
KW - CYTOKINES
KW - CELL receptors
KW - LYMPHOKINES
N1 - Accession Number: 13383273; Puri, R.K. 1; Finbloom, D.S. 1; Leland, P. 1; Mostowski, H. 1; Siegel, J.P. 1; Source Information: Aug90, Vol. 70 Issue 4, p492; Subject: LYMPHOCYTES; Subject: TUMORS; Subject: INTERLEUKIN-2; Subject: CYTOKINES; Subject: CELL receptors; Subject: LYMPHOKINES; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Shaw Jr., Frederic E.
AU - Shapiro, Craig N.
AU - Welty, Thomas K.
AU - Dill, William
AU - Reddington, Jay
AU - Hadler, Stephen C.
T1 - Hepatitis Transmission Among the Sioux Indians of South Dakota.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/09//
VL - 80
IS - 9
M3 - Article
SP - 1091
EP - 1094
PB - American Public Health Association
SN - 00900036
AB - Hepatitis A continues to occur in cyclical community-wide epidemics on the Indian reservations of South Dakota. In June 1985 a population-based serosurvey for viral hepatitis involving 120 households was conducted at the Pine Ridge and Rosebud Sioux Indian reservations in South Dakota. The serosurvey was performed shortly after a large hepatitis A epidemic on the Pine Ridge reservation in 1983-44, and immediately before a large hepatitis A epidemic on the Rosebud reservation in 1985-86. The overall seroprevalence for antibodies to hepatitis A virus (anti-HAV) was 76.2 percent (Pine Ridge reservation 80.5 percent, Rosebud reservation 72.0 percent, relative risk = 1.12, 95 percent confidence interval = 1.01, 1.24). For age groups 0 to 4 years, 54.2 percent and 36.1 percent of children were seropositive at Pine Ridge and Rosebud, respectively. Seropositivity rose rapidly with age by age 40, more than 90 percent of persons at both Pine Ridge and Rosebud were anti-HAV positives. Only 1.1 percent of persons tested were positive for hepatitis B markers, Anti-HAV seroprevalence rates in both communities are similar to rates observed in developing countries. The surprisingly high anti-HAV seroprevalence among young children at Rosebud, where clinical hepatitis A had been virtually absent in the previous seven years, indicates that high-grade silent transmission was taking place during the interepidemic period. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterovirus diseases
KW - Epidemics
KW - Hepatitis
KW - Communicable diseases
KW - Hepatitis A
KW - Viral hepatitis
KW - Native Americans -- Reservations -- South Dakota
KW - Inflammation
KW - Liver diseases
N1 - Accession Number: 9101281034; Shaw Jr., Frederic E. 1; Shapiro, Craig N. 1; Welty, Thomas K. 2; Dill, William 2; Reddington, Jay 1; Hadler, Stephen C. 1; Affiliations: 1: Hepatitis Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA; 2: Aberdeen Area Indian Health Service, Public Health Service Indian Hospital, Rapid City, SD; Issue Info: Sept90, Vol. 80 Issue 9, p1091; Thesaurus Term: Enterovirus diseases; Thesaurus Term: Epidemics; Thesaurus Term: Hepatitis; Thesaurus Term: Communicable diseases; Subject Term: Hepatitis A; Subject Term: Viral hepatitis; Subject Term: Native Americans -- Reservations -- South Dakota; Subject Term: Inflammation; Subject Term: Liver diseases; Number of Pages: 4p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1991-15631-001
AN - 1991-15631-001
AU - Zitzow, Darryl
T1 - Ojibway adolescent time spent with parents/elders as related to delinquency and court adjudication experiences.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1990///Fal 1990
VL - 4
IS - 1
SP - 53
EP - 63
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1991-15631-001. PMID: 2098167 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Zitzow, Darryl; PHS Indian Health Service, White Earth Clinic, MN, US. Release Date: 19910601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adjudication; American Indians; Intergenerational Relations; Juvenile Delinquency; Parent Child Relations. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: Fal 1990.
AB - Surveyed 94 Ojibway adolescents (aged 12–18 yrs) as to the quantity of time spent with and away from families in a variety of areas (e.g., eating, working, recreation, spiritual activities). Results indicate that adolescents experiencing greater volume of family contact tended to have less involvement with both court adjudication and delinquency behaviors. Increased frequency of family dysfunctional factors (e.g., substance use, domestic abuse, negative well-being) served as a predictor of adolescent involvement with court adjudication and juvenile delinquency. Recommendations for practitioners are outlined based on reconstructing family support and skill development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - time spent with parents/elders
KW - delinquency & court adjudication experiences
KW - 12–18 yr old Ojibways
KW - 1990
KW - Adjudication
KW - American Indians
KW - Intergenerational Relations
KW - Juvenile Delinquency
KW - Parent Child Relations
KW - 1990
DO - 10.5820/aian.0401.1990.53
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1991-06880-001
AN - 1991-06880-001
AU - Pontieri, Francesco E.
AU - Crane, Alison M.
AU - Seiden, Lewis S.
AU - Kleven, Mark S.
AU - Porrino, Linda J.
T1 - Metabolic mapping of the effects of intravenous methamphetamine administration in freely moving rats.
JF - Psychopharmacology
JO - Psychopharmacology
JA - Psychopharmacology (Berl)
Y1 - 1990/10//
VL - 102
IS - 2
SP - 175
EP - 182
CY - Germany
PB - Springer
SN - 0033-3158
SN - 1432-2072
N1 - Accession Number: 1991-06880-001. PMID: 1980372 Other Journal Title: Psychopharmacologia. Partial author list: First Author & Affiliation: Pontieri, Francesco E.; US Dept of Health & Human Services Public Health Service, NIMH Lab of Cerebral Metabolism, Bethesda, MD, US. Release Date: 19910301. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Glucose; Methamphetamine; Neurochemistry. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Page Count: 8. Issue Publication Date: Oct, 1990.
AB - Methamphetamine (MAMP) in male rats resulted in widespread dose-dependent increases in local cerebral glucose utilization (CGU) in structures of the extrapyramidal motor system. Rates of CGU correlated positively with locomotor activity. In the limbic system, alterations in metabolic activity were smaller and more selective. CGU was increased in the nucleus accumbens at all doses, but alterations in CGU in the ventral tegmental area, amygdala, and anterior cingulate were observed only at the highest doses of MAMP. Significant increases in rates of glucose metabolism were found in the substantia nigra compacta and the median and dorsal raphe nuclei. Dopamine and serotonin (5-hydroxytryptamine [5-HT]) were also depleted in these regions and in the ventral tegmental area. Changes in CGU may indicate disturbances in biochemical processes in the neurotoxic effects of MAMP. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methamphetamine
KW - rates of local cerebral glucose utilization
KW - freely moving male rats
KW - 1990
KW - Glucose
KW - Methamphetamine
KW - Neurochemistry
KW - Rats
KW - 1990
DO - 10.1007/BF02245919
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1991-06880-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Locke, Martin A.
AU - Pothuluri, Jairaj V.
AU - Moorman, Thomas B.
AU - Harper, Sidney S.
T1 - Efficiency of methanol:Water solutions for metribuzin extraction from selected soils.
JO - Communications in Soil Science & Plant Analysis
JF - Communications in Soil Science & Plant Analysis
Y1 - 1990/11//
VL - 21
IS - 17/18
M3 - Article
SP - 2141
EP - 2152
SN - 00103624
AB - Extraction efficiency for metribuzin [4‐amino‐6‐(1,1‐dimethyl‐ethy 1)‐3‐(methylthio)‐l,2,4‐triazin‐5(4H)‐one] from soil was evaluated using four solutions of methanol:water at ratios of 1:1, 7:3, 4:1, and 1:0 v/v. Two concentrations of metribuzin (O.216 and 2.44 ug/ g soil, unlabeled and I4C‐metribuzin, respectively) were added to surface and subsurface samples of a Dundee silt loam soil. Although the differences in extraction efficiencies were slight due to differences in methanol:water ratios, the metribuzin recovery varied with soil depth. Less metribuzin was recovered from surface soil extracted with 1:1 and 1:0 methanol:water solutions when compared to 7:3 and 4:1 solutions (80 and 81% vs 89 and 88% recoveries, respectively). About equal quantities, 81 to 85%, were recovered from the subsurface soil. Three extraction shaking times (0.5 h followed by another 0.5 h; 4 h:4 h; and 24 h:24 h) were also evaluated using the 4:1 extractant. No recovery differences were observed between the 0.5 h and 4 h shaking times. However, significantly higher recoveries occurred in both the surface and subsurface soil with 24 h shaking. The efficiency of this method was also determined on Eustis loamy sand, Sharkey clay, and Dorovan muck soils of diverse physical and chemical properties. The 4:1 extracting solution consistently yielded among the highest metribuzin recovery (74 to 97%) from the four soil types, and two soil depths of a Dundee soil. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications in Soil Science & Plant Analysis is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metribuzin
KW - Solution (Chemistry)
KW - Soil testing
KW - Soil sampling
KW - Soil structure
KW - Soil physical chemistry
KW - Soil depth
KW - Soil classification
N1 - Accession Number: 75295610; Locke, Martin A. 1; Pothuluri, Jairaj V. 1,2; Moorman, Thomas B. 1; Harper, Sidney S. 1,3; Affiliations: 1: USD A‐ARS, Southern Weed Science Laboratory, Stoneville, Mississippi, 38776; 2: National Center for Toxicological Research, FDA, Jefferson, AR, 72079; 3: Tennessee Valley Authority, NFDC, Muscle Shoals, AL, 35660; Issue Info: Nov1990, Vol. 21 Issue 17/18, p2141; Thesaurus Term: Metribuzin; Thesaurus Term: Solution (Chemistry); Thesaurus Term: Soil testing; Thesaurus Term: Soil sampling; Thesaurus Term: Soil structure; Thesaurus Term: Soil physical chemistry; Thesaurus Term: Soil depth; Subject Term: Soil classification; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/00103629009368365
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107496973
T1 - Head injury--associated deaths from motorcycle crashes. Relationship to helmet-use laws.
AU - Sosin DM
AU - Sacks JJ
AU - Holmgreen P
AU - Sosin, D M
AU - Sacks, J J
AU - Holmgreen, P
Y1 - 1990/11/14/
N1 - Accession Number: 107496973. Language: English. Entry Date: 19910201. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Accidents, Traffic
KW - Mortality
KW - Head Protective Devices -- Utilization
KW - Head Protective Devices -- Legislation and Jurisprudence -- United States
KW - Head Injuries
KW - Case Control Studies
KW - United States
KW - Epidemiological Research
KW - Motor Vehicles
KW - Adolescence
KW - Adult
KW - Human
SP - 2395
EP - 2399
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 264
IS - 18
CY - Chicago, Illinois
PB - American Medical Association
AB - A review of US mortality data from 1979 to 1986 identified 15,194 deaths and nearly 600,000 years of potential life lost before age 65 years that were associated with head injuries from motorcycle crashes. White males from 15 to 34 years of age accounted for 69% of the deaths. The rate of motorcycle-related deaths associated with head injury declined modestly between 1979 and 1986 (19% using rates based on resident population and 8% based on motorcycle registrations). Population-based rates adjusted for age, sex, and race in states with partial or no motorcycle helmet-use laws were almost twice those in states with comprehensive helmet-use laws. Two states that weakened their helmet-use laws from comprehensive to partial during the study period had increases in motorcycle-related head injury death rates (184% and 73%), and one state that strengthened its law from partial to comprehensive had a decline in its death rate (44%). Head injury death rates based on motorcycle registrations were also lowest in states with comprehensive helmet-use laws. Since helmets reduce the severity of nonfatal head injuries in addition to lowering the rate of fatal injuries, we urge the adoption and enforcement of comprehensive motorcycle helmet-use legislation.
SN - 0098-7484
AD - Division of Injury Control, Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga 30333
U2 - PMID: 2231995.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pappas, Gregory
AU - Gergen, Peter J.
AU - Carroll, Margaret
T1 - Hypertension Prevalence and the Status of Awareness, Treatment, and Control in the Hispanic: Findings from HHANES 1982-84.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/12//
VL - 80
IS - 12
M3 - Article
SP - 1431
EP - 1437
PB - American Public Health Association
SN - 00900036
AB - The prevalence rates of hypertension among adult (ages 18-74) Mexican Americans, Cuban Americans, and Puerto Ricans were estimated using data from the 1982-84 Hispanic Health and Nutrition Examination Survey (HHANES). Hypertension is defined as diastolic greater than or equal to 90 mm Hg, or systolic greater than or equal to 140 mm Hg, or currently taking antihypertensive medication. Among Mexican Americans in the Southwestern United States, 16.8 percent of the males and 14.1 percent or the females were found to he hypertensive, Among Cuban Americans in Dade County, Florida 22.8 percent of the males and 15.5 percent of the females were hypertensive. Among Puerto Ricans in the New York City area 15.6 percent of the mates and 11.5 percent of the females were hypertensive. The age-adjusted rates are significantly lower than comparable rates for Whites and Blacks as measured in the second National Health and Nutrition Examination Survey (NHANES II), 1976-80. Control of hypertension in the HHANES populations fall short of the 1990 Objectives for the Nation established by the US Public Health Service 60 percent (34 percent controlled Mexican American hypertensives, 27.8 percent controlled Cuban American hypertensives, and 29 percent controlled Puerto Rican hypertensives). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Hypertension
KW - Blood circulation disorders
KW - Cardiovascular diseases
KW - Hispanic Americans
KW - Latin Americans -- United States
KW - Mexican Americans
KW - Cuban Americans
KW - Puerto Ricans
N1 - Accession Number: 9012241105; Pappas, Gregory 1; Gergen, Peter J. 1; Carroll, Margaret 1; Affiliations: 1: National Center for Health Statistics, Dept. of Health & Human Services, US Public Health Service; Issue Info: Dec1990, Vol. 80 Issue 12, p1431; Thesaurus Term: Public health; Subject Term: Hypertension; Subject Term: Blood circulation disorders; Subject Term: Cardiovascular diseases; Subject Term: Hispanic Americans; Subject Term: Latin Americans -- United States; Subject Term: Mexican Americans; Subject Term: Cuban Americans; Subject Term: Puerto Ricans; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1992-28637-001
AN - 1992-28637-001
AU - DeBruyn, LeMyra M
T1 - Tewa children who have epilepsy: A health care dilemma.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1990///Win 1990
VL - 4
IS - 2
SP - 25
EP - 41
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1992-28637-001. PMID: 2133207 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: DeBruyn, LeMyra M; Indian Health Service Mental Health Programs Branch, Special Initiatives Team, Albuquerque, NM, US. Release Date: 19920801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Health Care Services; Racial and Ethnic Differences; Sociocultural Factors. Minor Descriptor: Epilepsy; Health Care Delivery. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 17. Issue Publication Date: Win 1990.
AB - Explored the part ethnicity may play in utilization of available Western health care methods by 31 Tewa families who have a child with epilepsy. Suggestions are made for appropriate responses by non-Indian health care providers to Tewa patients with epilepsy and their families. Tewa families behave much like other Americans in utilization of Western health care services. However, the Tewa are extremely reluctant to discuss with non-Indian health care providers traditional healing practices that may be used simultaneously. Suggestions are made for health care providers who wish to be culturally aware about the appropriateness of routinely asking a patient about his/her perception of the traditional etiology of the disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnicity
KW - utilization of Western health care services & traditional healing practices
KW - Tewa families with epileptic child
KW - implications for need for cultural sensitivity by non-Indian providers
KW - 1990
KW - American Indians
KW - Health Care Services
KW - Racial and Ethnic Differences
KW - Sociocultural Factors
KW - Epilepsy
KW - Health Care Delivery
KW - 1990
DO - 10.5820/aian.0402.1990.25
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1994-97773-005
AN - 1994-97773-005
AU - Darrow, William W.
ED - Ulack, Richard
ED - Skinner, William Francis
ED - Ulack, Richard, (Ed)
ED - Skinner, William Francis, (Ed)
T1 - AIDS: Socioepidemiologic responses to an epidemic.
T2 - AIDS and the social sciences: Common threads.
Y1 - 1991///
SP - 82
EP - 99
CY - Lexington, KY, US
PB - University Press of Kentucky
SN - 0-8131-1760-7
N1 - Accession Number: 1994-97773-005. Partial author list: First Author & Affiliation: Darrow, William W.; US Dept of Health & Human Services, Public Health Service, Ctrs for Disease Control, Ctr for Infectious Diseases, Div of HIV/AIDS, Epidemiology Branch, Social & Behavioral Studies Section, Washington, DC, US. Release Date: 19941101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8131-1760-7, Hardcover. Language: English. Major Descriptor: AIDS; Epidemiology; Sociology. Minor Descriptor: Heterosexuality; HIV; Interdisciplinary Research; Prostitution; Rural Environments; Towns. Classification: Immunological Disorders (3291). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 18.
AB - explores how the principles of sociology and epidemiology can be applied to an understanding of AIDS through the case study approach / examines recent studies involving heterosexual transmission of HIV, discusses HIV prevalence among prostitutes, and offers suggestions for future research / discusses the increasing incidence of the disease in smaller towns and rural areas of the US (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - socioepidemiologic case study approach to AIDS & heterosexual transmission & prevalence among prostitutes & increasing incidence of HIV in small towns & rural areas
KW - 1991
KW - AIDS
KW - Epidemiology
KW - Sociology
KW - Heterosexuality
KW - HIV
KW - Interdisciplinary Research
KW - Prostitution
KW - Rural Environments
KW - Towns
KW - 1991
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gerstman, B. Burt
AU - Gross, Thomas P.
AU - Kennedy, Dianne L.
AU - Bennett, Ridgely C.
AU - Tomita, Dianne K.
AU - Stadel, Bruce V.
T1 - Trends in the Content and Use of Oral Contraceptives in the United States, 1964-88.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/01//
VL - 81
IS - 1
M3 - Article
SP - 90
EP - 96
PB - American Public Health Association
SN - 00900036
AB - Drug marketing and physician survey data were used to examine trends in the use and hormonal content of oral contraceptives in the United States between 1964 and 1988. Retail prescriptions for oral contraceptives peaked at approximately 68 million in 1973 and have remained between 50 million and 60 million since 1981. Despite this relative consistency in the number of prescriptions, physician "mentions" of oral contraceptives have increased by approximately 75 percent. This increase may reflect closer monitoring of women on oral contraceptives. Use of multiphasic formulations has steadily risen, accounting for 37 percent of the oral contraceptive prescriptions in 1988. Mean estrogen and progestin doses in all types of formulations have steadily declined. A change in the type of estrogen and progestin used in preparations has coincided with this decline in dose. The association between age and use of high-dose formulations seen in the past was no longer evident in 1988. The data demonstrate that oral contraceptive formulations in wide use today differ in hormone content from those of the past, when most of the major studies addressing the risks associated with oral contraceptive use were completed. There is therefore a need to determine the risks and long-term effects associated with these newer formulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs
KW - Contraceptive drugs
KW - Oral contraceptives
KW - Drugs -- Marketing
KW - Prescription of drugs
KW - Estrogen
KW - Progestational hormones
KW - Surveys
KW - United States
N1 - Accession Number: 9103182520; Gerstman, B. Burt 1; Gross, Thomas P. 1; Kennedy, Dianne L. 1; Bennett, Ridgely C. 1; Tomita, Dianne K. 1; Stadel, Bruce V. 2; Affiliations: 1: Office of Epidemiology and Biostatistics, HFD-733, Food and Drug Administration, Rockville, MD 20857; 2: Division of Endocrine and Metabolic Drug Products, Rockville, MD 20857; Issue Info: Jan1991, Vol. 81 Issue 1, p90; Thesaurus Term: Drugs; Subject Term: Contraceptive drugs; Subject Term: Oral contraceptives; Subject Term: Drugs -- Marketing; Subject Term: Prescription of drugs; Subject Term: Estrogen; Subject Term: Progestational hormones; Subject Term: Surveys; Subject: United States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Puri, R. K.
AU - Leland, P.
AU - Razzaque, A.
T1 - Antigen(s)-specific tumour-infiltrating lymphocytes from tumour induced by human herpes virus-6 (HHV-6) DNA transfected NIH 3T3 transformants.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1991/01//
VL - 83
IS - 1
M3 - Article
SP - 96
EP - 101
SN - 00099104
AB - Tumour infiltrating lymphocytes (TIL) have recently been shown to mediate potent therapeutic effects in certain malignancies in mice and in humans. To understand the mechanism of TIL immunotherapy it would be advantageous to generate tumour-specific TIL and to study a defined system of TIL and target cells in which the tumour epitope(s) recognized by TIL might be identified. We have established tumourigenic cell lines by transfection of NIH 3T3 cells with the entire genome of human herpesvirus-6 (HHV-6) and its small fragment (about 5% of the viral DNA sequence). Injection of these cells into nude mice produced tumours termed G-2T and 14-2T, respectively. Cell lines derived from these tumours when injected in NIH Swiss mice produced tumours, G-2TS and 14-2TS, respectively. We have generated TIL from G-2TS tumour that can kill G-2TS tumour cells in vitro but not other related tumours (14-2TS or MCA-106). These TIL can be expanded between 2-6.5 every 3-5 days. The TIL proliferated in tissue culture in response to recombinant interleukin-2 and interleukin-4 and maintained their tumour specificity for up to 6 months in vitro. Their phenotype was Thy 1.2+, Lyt-2+ and L3T4- . The availability of such tumour-specific stable TIL lines and specific viral-transformed targets will provide an opportunity to characterize the tumour-associated antigen critical for the specific cytotoxicity in this system and thereby lo clarify the mechanism of this promising immunological approach to cancer therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - LYMPHOCYTES
KW - IMMUNOTHERAPY
KW - NUCLEOTIDE sequence
KW - HUMAN herpesvirus-6
KW - CANCER treatment
KW - GENETIC transformation
KW - tumour-infiltrating lymphocytes cancer immunotherapy HHV-6 interleukin-2
N1 - Accession Number: 15988006; Puri, R. K. 1; Leland, P. 1; Razzaque, A. 2; Source Information: Jan1991, Vol. 83 Issue 1, p96; Subject: ANTIGENS; Subject: LYMPHOCYTES; Subject: IMMUNOTHERAPY; Subject: NUCLEOTIDE sequence; Subject: HUMAN herpesvirus-6; Subject: CANCER treatment; Subject: GENETIC transformation; Author-Supplied Keyword: tumour-infiltrating lymphocytes cancer immunotherapy HHV-6 interleukin-2; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Temple, R J
T1 - Access, science, and regulation
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1991///
VL - 25
IS - 1
M3 - Article
SP - 1
EP - 12
SN - 00928615
AB - This paper examines the tension between the early availability of medicines that appear able to treat serious diseases for which there is no adequate therapy, and the orderly, scientific, data-driven process of developing and evaluating new medicines. The issue of access to therapy is examined. The possible bases for arguing that promising treatments for otherwise untreatable conditions should be made more easily available are reviewed.
KW - MEDICINE
KW - Drug information
KW - Healthcare
KW - Pharmacy
N1 - Accession Number: ISTA2602243; Temple, R J 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: 1991, Vol. 25 Issue 1, p1; Note: Update Code: 2600; Subject Term: MEDICINE; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Healthcare; Author-Supplied Keyword: Pharmacy; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - GEN
AU - Gelberg, A
AU - Armstrong, G D
AU - Dreis, M W
T1 - Technological developments with the FDA adverse drug reaction file system
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1991///
VL - 25
IS - 1
M3 - Article
SP - 19
EP - 28
SN - 00928615
AB - The authors provide a review of the Food and Drug Administration (FDA) Adverse Drug Reaction (ADR) file system. They describe the current operations for maintaining the on-line computerized data entry, storage and retrieval programs, and the microfilm retrieval system. Other technology developments discussed include data diskette exchange and laser disc storage and retrieval.
KW - Computerization
KW - Disk storage
KW - Drug information
KW - Federal government
N1 - Accession Number: ISTA2602242; Gelberg, A 1; Armstrong, G D; Dreis, M W; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: 1991, Vol. 25 Issue 1, p19; Note: Update Code: 2600; Author-Supplied Keyword: Computerization; Author-Supplied Keyword: Disk storage; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 104749454
T1 - The history of the International Classification of Diseases.
AU - Israel, R A
Y1 - 1991/01//1991 Jan
N1 - Accession Number: 104749454. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 0012330.
KW - Disease -- Classification
KW - Nomenclature
KW - Cause of Death
KW - History
KW - International Relations
KW - Statistics -- History
SP - 62
EP - 66
JO - Health Bulletin
JF - Health Bulletin
JA - HEALTH BULL
VL - 49
IS - 1
PB - Scottish Home & Health Department Edinburgh
SN - 0374-8014
AD - National Center for Health Statistics, Centers for Disease Control, US Public Health Service, Hyattsville, MD 20782.
U2 - PMID: 1938377.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Black, C. M.
AU - McDougal, J. S.
AU - Evatt, B. L.
AU - Reimer, C. B.
T1 - Human markers for IgG2 and IgG4 appear to be on the same molecule in the chimpanzee.
JO - Immunology
JF - Immunology
Y1 - 1991/01//
VL - 72
IS - 1
M3 - Article
SP - 94
EP - 98
SN - 00192805
AB - It has been reported that all four immunoglobulin G (IgG) subclasses present in human serum are also present in chimpanzee serum, as detected with antibodies specific for the human IgG subclasses. We used monoclonal antibodies (mAb) specific for human IgG subclasses to measure concentrations of thc four subclasses in chimpanzee sera. Initial ELISA studies indicated that epitopes for all four human subclasses are present in chimpanzee sera. The concentrations of IgG1, IgG2 and IgG3 were similar in human and chimpanzee sera, but the registered concentrations of IgG4 were different. Absorption of IgG2-reactive material from chimpanzee serum with IgG2 mAb resulted in removal of IgG4-reactive material as well. Conversely, absorption of IgG4-reactive material removed IgG2reactive material, IgG2-reactive material, isolated from chimpanzee serum using solid-phase antiIgG2 mAb, reacted with anti-IgG4 mAb, and isolated IgG4-reactive material reacted with anti-IgG2 mAb. Three anti-IgG2 mAb and five anti-IgG4 mAb, each of which react with separate epitopes on their respective human isotype, were used in these studies. We conclude that chimpanzee serum contains only three IgG isotypes related to those of humans, one of which contains determinants related to both human IgG2 and IgG4. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN G
KW - MONOCLONAL antibodies
KW - ENZYME-linked immunosorbent assay
KW - CHIMPANZEES as laboratory animals
KW - IMMUNOLOGY -- Animal models
N1 - Accession Number: 13385576; Black, C. M. 1; McDougal, J. S. 1; Evatt, B. L. 1; Reimer, C. B.; Source Information: Jan1991, Vol. 72 Issue 1, p94; Subject: IMMUNOGLOBULIN G; Subject: MONOCLONAL antibodies; Subject: ENZYME-linked immunosorbent assay; Subject: CHIMPANZEES as laboratory animals; Subject: IMMUNOLOGY -- Animal models; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=13385576&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - CONF
ID - 109874550
T1 - Prescriptive authority for nurses and its relationship to professional autonomy, physician substitution, competition and cost-effective health services.
AU - Hadley EH
Y1 - 1991/01//
N1 - Accession Number: 109874550. Language: English. Entry Date: 20020222. Revision Date: 20150923. Publication Type: Proceedings.
KW - Prescriptive Authority
KW - Nurse Practice Acts
KW - Professional Regulation
KW - Professional Practice
KW - Scope of Nursing Practice
KW - Nursing Practice
KW - Licensure, Nursing
KW - United States
KW - Prescriptive Authority -- Legislation and Jurisprudence -- United States
KW - Medicine
KW - Advanced Practice Nurses
KW - Supervisors and Supervision
KW - Physicians
KW - Idaho
KW - Connecticut
KW - New York
KW - Washington
KW - Alaska
KW - Oregon
KW - North Carolina
KW - California
KW - Professional Autonomy
KW - Health Services
KW - Advanced Nursing Practice
KW - Certification
SP - 1
EP - 9
JO - Nurses & Prescriptive Authority, Specialty Nursing Forum, Clemson University College of Nursing, National Conference Proceedings, October 5-7, 1990, U.S. Grant Hotel, San Diego, Ca
JF - Nurses & Prescriptive Authority, Specialty Nursing Forum, Clemson University College of Nursing, National Conference Proceedings, October 5-7, 1990, U.S. Grant Hotel, San Diego, Ca
AD - Attorney Advisor, Office of Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109874550&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CONF
ID - 109874564
T1 - An alternative prescriptive authority legislative model.
AU - Hadley EH
Y1 - 1991/01//
N1 - Accession Number: 109874564. Language: English. Entry Date: 20020222. Revision Date: 20150923. Publication Type: Proceedings.
KW - Prescriptive Authority -- Legislation and Jurisprudence -- United States
KW - United States
KW - Licensure -- Legislation and Jurisprudence -- United States
KW - Professional Practice -- Legislation and Jurisprudence -- United States
KW - Legislation -- United States
SP - 103
EP - 113
JO - Nurses & Prescriptive Authority, Specialty Nursing Forum, Clemson University College of Nursing, National Conference Proceedings, October 5-7, 1990, U.S. Grant Hotel, San Diego, Ca
JF - Nurses & Prescriptive Authority, Specialty Nursing Forum, Clemson University College of Nursing, National Conference Proceedings, October 5-7, 1990, U.S. Grant Hotel, San Diego, Ca
AD - Attorney Advisor, Office of Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109874564&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Prescott, Patricia A.
T1 - Forecasting Requirements for Health Care Personnel.
JO - Nursing Economic$
JF - Nursing Economic$
Y1 - 1991/01//Jan/Feb91
VL - 9
IS - 1
M3 - Article
SP - 18
EP - 24
PB - Jannetti Publications, Inc.
SN - 07461739
AB - The article focuses on the forecasting requirements for health care personnel. Health care spending in the U.S. is the largest in the world in both absolute and relative terms and continues to grow despite cost-containment efforts. This study highlights some of the complexities associated with forecasting requirements for health care personnel by first identifying the major previous approaches to manpower forecasting. From a review of five general approaches, analytic components for a comprehensive model are suggested and discussed regarding their importance for understanding disequilibrium, particularly shortages, in the providers of health care services.
KW - MEDICAL personnel
KW - MEDICAL care
KW - FORECASTING
KW - SPECIFICATIONS
KW - MANPOWER
KW - UNITED States
N1 - Accession Number: 12175931; Prescott, Patricia A. 1; Source Information: Jan/Feb91, Vol. 9 Issue 1, p18; Subject: MEDICAL personnel; Subject: MEDICAL care; Subject: FORECASTING; Subject: SPECIFICATIONS; Subject: MANPOWER; Geographic Terms: UNITED States; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=12175931&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1993-06996-001
AN - 1993-06996-001
AU - Meachen, Sarah E.
AU - Kelley, Susan D.
T1 - Special issues in prenatal care outreach.
JF - Journal of Health & Social Policy
JO - Journal of Health & Social Policy
JA - J Health Soc Policy
Y1 - 1991///
VL - 2
IS - 3
SP - 53
EP - 67
CY - US
PB - Haworth Press
SN - 0897-7186
N1 - Accession Number: 1993-06996-001. PMID: 10116394 Partial author list: First Author & Affiliation: Meachen, Sarah E.; US Public Health Service, Div of Community Health Services, US. Release Date: 19930201. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Mothers; Birth Weight; Lower Income Level; Mothers; Prenatal Care. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 15. Issue Publication Date: 1991.
AB - Interviewed 986 low-income adolescent and adult mothers regarding when they sought and obtained prenatal care. Ss were grouped into those who received care in their 1st trimester, 3rd trimester, or not at all. Regardless of trimester of entry, Ss who came for prenatal care reported unsuccessful requests for prenatal care prior to entry into the public health system. The likelihood of having a low-birthweight baby increased with increased delay between seeking care and receiving care. Ss who obtained pregnancy tests but did not seek prenatal care obtained these tests in a variety of private and public health care facilities. 62% of the Ss had some interaction with the Medicaid program; these Ss potentially could be reached through public welfare application centers. Nearly 25% of the Ss who sought care late or not at all admitted to a lack of knowledge about when is the best time to begin care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trimester of entry into prenatal care & infant birth weight
KW - low income adolescent & adult mothers
KW - 1991
KW - Adolescent Mothers
KW - Birth Weight
KW - Lower Income Level
KW - Mothers
KW - Prenatal Care
KW - 1991
DO - 10.1300/J045v02n03_04
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-06996-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1992-28853-001
AN - 1992-28853-001
AU - Ruttenber, A. James
T1 - Stalking the elusive designer drugs: Techniques for monitoring new problems in drug abuse.
JF - Journal of Addictive Diseases
JO - Journal of Addictive Diseases
JA - J Addict Dis
Y1 - 1991///
VL - 11
IS - 1
SP - 71
EP - 87
CY - US
PB - Haworth Press
SN - 1055-0887
SN - 1545-0848
N1 - Accession Number: 1992-28853-001. PMID: 1790155 Other Journal Title: Advances in Alcohol & Substance Abuse. Partial author list: First Author & Affiliation: Ruttenber, A. James; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control Ctr for Environmental Health & Injury Control, Atlanta, GA, US. Other Publishers: Taylor & Francis. Release Date: 19920801. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drugs; Epidemiology; Public Health Services. Minor Descriptor: Amphetamine; Fentanyl; Meperidine; Methylenedioxymethamphetamine; Phencyclidine; Designer Drugs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Page Count: 17. Issue Publication Date: 1991.
AB - Describes the designer drugs that have been popular in the 1980s, documents instances of their occurrence in US communities, and discusses ways to provide surveillance and public health intervention for the drugs that produce severe health problems. The drugs include analogs of fentanyl, meperidine, amphetamines and other stimulants, 3,4-methylenedioxyamphetamine, and phencyclidine. Recommendations include establishing criteria for reporting the appearance of designer drugs and their adverse health affects, improving the current network of government agencies that are affected by designer drug production, and establishing services such as the Up Front Drug Information Service. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - surveillance & public health interventions for monitoring abuse of fentanyl & amphetamines & meperidine & PCP analogs and other designer drugs
KW - 1991
KW - Drug Abuse
KW - Drugs
KW - Epidemiology
KW - Public Health Services
KW - Amphetamine
KW - Fentanyl
KW - Meperidine
KW - Methylenedioxymethamphetamine
KW - Phencyclidine
KW - Designer Drugs
KW - 1991
DO - 10.1300/J069v11n01_07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1992-28853-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107506001
T1 - A new look at typhoid vaccination. Information for the practicing physician.
AU - Woodruff BA
AU - Pavia AT
AU - Blake PA
AU - Woodruff, B A
AU - Pavia, A T
AU - Blake, P A
Y1 - 1991/02/13/
N1 - Accession Number: 107506001. Language: English. Entry Date: 19910901. Revision Date: 20161112. Publication Type: journal article; tables/charts. Commentary: Kaplan D T, Hill D R. Compliance with live, oral Ty21a typhoid vaccine. (JAMA) 2/26/92; 267 (8): 1074-1074. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Typhoid -- Prevention and Control
KW - Bacterial Vaccines
KW - Immunization
KW - United States
KW - Bacterial Vaccines -- Adverse Effects
KW - Bacterial Vaccines -- Administration and Dosage
KW - Capsules
KW - Injections, Subcutaneous
SP - 756
EP - 759
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 265
IS - 6
CY - Chicago, Illinois
PB - American Medical Association
AB - Most cases of typhoid fever in the United States occur in international travelers, with the greatest risk associated with travel to Peru, India, Pakistan, and Chile. Laboratory workers and household contacts of long-term carriers are also at greater risk than the general population. Decisions to the use typhoid vaccine involve weighing the risk of illness against the risk of vaccine reactions. Until recently, the only typhoid vaccine commercially available to US civilians was a heat-phenol-inactivated parenteral product that is 51% to 77% effective in preventing typhoid fever but frequently produces local pain and swelling, fever, headache, and malaise. A new orally administered, live-attenuated vaccine, made from the Ty21a strain of Salmonella typhi, has been recently licensed in the United States. This vaccine provides equivalent protection with a much lower incidence of adverse reactions. It is administered in a four-dose series given over 7 days. Since neither vaccine offers total protection, the most important elements in prevention of typhoid fever remain sound biosafety precautions in laboratory workers and care in selecting food and beverages by those traveling to areas where typhoid fever is endemic.
SN - 0098-7484
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Atlanta, Ga 30333
U2 - PMID: 1990193.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Novello, Antonia C.
AU - Wise, Paul H.
AU - Kleinman, Dushanka V.
AU - Orenstein, Walter A.
AU - Sepe, Stephen I.
AU - Novello, A C
AU - Wise, P H
AU - Kleinman, D V
AU - Orenstein, W A
AU - Sepe, S I
T1 - From the Surgeon General, US Public Health Service.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/03/20/
VL - 265
IS - 11
M3 - journal article
SP - 1364
EP - 1364
SN - 00987484
AB - Reflects on the efforts of the U.S. medical community to meet the first goal of the National Education Summit that children will receive the nutrition and care needed to arrive at school with healthy minds and bodies. Primary care services for children; Immunization; Challenges posed by the objective.
KW - CHILD nutrition -- Psychological aspects
KW - CHILD care
KW - CHILDREN -- Health
KW - EDUCATION -- United States
KW - UNITED States
N1 - Accession Number: 10415747; Novello, Antonia C.; Wise, Paul H.; Kleinman, Dushanka V.; Orenstein, Walter A.; Sepe, Stephen I.; Novello, A C 1; Wise, P H; Kleinman, D V; Orenstein, W A; Sepe, S I; Source Information: 3/20/91, Vol. 265 Issue 11, p1364; Subject: CHILD nutrition -- Psychological aspects; Subject: CHILD care; Subject: CHILDREN -- Health; Subject: EDUCATION -- United States; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Mason, James O.
AU - Mason, J O
T1 - From the Assistant Secretary for Health, US Public Health Service.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/04/24/
VL - 265
IS - 16
M3 - journal article
SP - 2049
EP - 2049
SN - 00987484
AB - Discusses the plan of the U.S. Public Health Service to eliminate childhood lead poisoning in the U.S. Prevalence of lead poisoning among children in the U.S.; Source of lead poisoning in children; Features of the plan of the U.S. Public Health Service.
KW - LEAD poisoning in children
KW - UNITED States. Public Health Service
KW - PUBLIC health -- United States
KW - JUVENILE diseases
KW - LEAD poisoning -- Prevention
KW - HEALTH promotion
KW - UNITED States
N1 - Accession Number: 10338442; Mason, James O.; Mason, J O 1; Source Information: 4/24/91, Vol. 265 Issue 16, p2049; Subject: LEAD poisoning in children; Subject: UNITED States. Public Health Service; Subject: PUBLIC health -- United States; Subject: JUVENILE diseases; Subject: LEAD poisoning -- Prevention; Subject: HEALTH promotion; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Thun, Michael J.
AU - Schober, Susan
T1 - Urolithiasis in Tennessee: An Occupational Window Into a Regional Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/05//
VL - 81
IS - 5
M3 - Article
SP - 587
EP - 591
PB - American Public Health Association
SN - 00900036
AB - Background: Urinary tract stones (stones) arc believed to be unusually common in the southeastern United States but neither the incidence of nor the risk factors for stones are known. Methods: In three well-defined occupational populations in eastern Tennessee, we assessed the prevalence, incidence, and cumulative incidence of stones and measured biochemical risk factors for lithogenesis. Results: The age-adjusted prevalence of stones was 18.5 percent in Tennessee compared to 7.7 percent among White males in US NHANES (prevalence ratio 2.4, 95% Cl 1.7, 3.3). The cumulative incidence (risk) was 27.8 percent by age 65, higher than in any other reported population. Risk factors were age, a family history, and urinary saturation with calcium-oxalate (COAX). Persons with a positive family history and the highest measured CAOX index had a predicted lifetime risk of 88.8 percent. Biochemical factors affecting lithogenesis were hypercalcuria, hyperoxaluria, and low urine volume. Conclusion: Future research should characterize the geographic boundaries of a southeastern "stone-belt" and explore genetic and dietary hypotheses that might explain it. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Pathology
KW - Public health
KW - Urinary calculi
KW - Urinary organs
KW - Kidney stones
KW - Urinary tract infections
KW - Genealogy
KW - Urology
KW - Tennessee
N1 - Accession Number: 9107081085; Thun, Michael J. 1; Schober, Susan 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May91, Vol. 81 Issue 5, p587; Thesaurus Term: DISEASES; Thesaurus Term: Pathology; Thesaurus Term: Public health; Subject Term: Urinary calculi; Subject Term: Urinary organs; Subject Term: Kidney stones; Subject Term: Urinary tract infections; Subject Term: Genealogy; Subject Term: Urology; Subject: Tennessee; NAICS/Industry Codes: 812990 All Other Personal Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1991-31385-001
AN - 1991-31385-001
AU - Leonard, Bruce
AU - Byers, Tim
AU - Campbell, Carolyn
AU - Wiese, William
T1 - HealthNet New Mexico: A community-based statewide health promotion program.
JF - American Journal of Health Promotion
JO - American Journal of Health Promotion
JA - Am J Health Promot
Y1 - 1991/05//May-Jun, 1991
VL - 5
IS - 5
SP - 368
EP - 377
CY - US
PB - American Journal of Health Promotion
SN - 0890-1171
SN - 2168-6602
N1 - Accession Number: 1991-31385-001. PMID: 10148763 Partial author list: First Author & Affiliation: Leonard, Bruce; Ctrs for Disease Control, Indian Health Service-Headquarters West, Albuquerque, NM, US. Other Publishers: Sage Publications. Release Date: 19911101. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Health Promotion. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 10. Issue Publication Date: May-Jun, 1991.
AB - Presents the history, design, and preliminary results of HealthNet's programs from 1986 to 1988. Discussion focuses on coalition building, use of media, and work site/institutional implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - history & design & preliminary results of HealthNet New Mexico's community based health promotion programs
KW - adults
KW - 1986–88
KW - 1991
KW - Community Services
KW - Health Promotion
KW - 1991
DO - 10.4278/0890-1171-5.5.368
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1991-31385-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1993-23940-001
AN - 1993-23940-001
AU - O'Carroll, Patrick W.
AU - Loftin, Colin
AU - Waller, John B.
AU - McDowall, David
AU - Bukoff, Allen
AU - Scott, Richard O.
AU - Mercy, James A.
AU - Wiersema, Brian
T1 - Preventing homicide: An evaluation of the efficacy of a Detroit gun ordinance.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 1991/05//
VL - 81
IS - 5
SP - 576
EP - 581
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 1993-23940-001. PMID: 2014857 Partial author list: First Author & Affiliation: O'Carroll, Patrick W.; US Public Health Service Ctrs for Disease Control, Ctr for Environmental Health & Injury Control Div of Injury Control, Atlanta, GA, US. Release Date: 19930601. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: Annual Meeting of the American Society for Criminology (1989, Reno, Nevada). Major Descriptor: Adjudication; Criminal Justice; Homicide; Laws; Weapons. Classification: Criminal Law & Adjudication (4230). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 6. Issue Publication Date: May, 1991.
AB - Conducted a set of interrupted time-series analyses to evaluate the impact of the law (i.e., requiring mandatory jail sentences for illegally carrying a firearm in public) on the incidence of homicides, hypothesizing that the ordinance, by its nature, would affect only firearm homicides and homicides committed outside (e.g., on the street). Findings are consistent with a model in which the ordinance had a dampening effect on firearm homicides occurring in public. The apparent preventive effect evident in the time series analyses may have been due to publicity about the ordinance, whereas the small nature of the effect may have been due to the lack of enforcement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gun ordinance
KW - public firearm homicides & enforcement of mandatory sentencing by criminal justice system
KW - conference presentation
KW - 1991
KW - Adjudication
KW - Criminal Justice
KW - Homicide
KW - Laws
KW - Weapons
KW - 1991
DO - 10.2105/AJPH.81.5.576
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-23940-001&site=ehost-live&scope=site
UR - ORCID: 0000-0003-4026-7888
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
T1 - Regulatory Issues in the Development and Future of the AICD.
AU - Acharya, Abhijit
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1991/05/15/
VL - 14
IS - 5P2
SP - 880
EP - 882
SN - 01478389
N1 - Accession Number: 17225229; Author: Acharya, Abhijit: 1 ; Author Affiliation: 1 Division of Cardiovascular Devices, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland; No. of Pages: 3; Language: English; Publication Type: Article; Update Code: 20050617
N2 - Focuses on government regulations governing the development and approval of the Automatic Implantable Cardioverter Defibrillator (AICD) in the U.S. Involvement of the U.S. Food and Drug Administration (FDA) in promoting developments of AICD; Result of premarket evalution of AICD; Conditions of AICD approval imposed by the FDA; Role of clinical trials in deveping AICD.
KW - *IMPLANTABLE cardioverter-defibrillators
KW - *DEFIBRILLATORS
KW - *IMPLANTED cardiovascular instruments
KW - MEDICAL equipment -- Government policy
KW - GOVERNMENT policy
KW - UNITED States
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=17225229&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Sullivan, Louis W.
AU - Sullivan, L W
T1 - From the Secretary of Health and Human Services.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/05/22/
VL - 265
IS - 20
M3 - journal article
SP - 2652
EP - 2652
SN - 00987484
AB - Presents the text of a speech given by Louis L. Sullivan, secretary of Health and Human Services of the U.S., which deals with child survival and AIDS in Africa.
KW - SULLIVAN, Louis
KW - UNITED States. Dept. of Health & Human Services
KW - AIDS (Disease)
KW - CHILDREN
KW - AFRICA
N1 - Accession Number: 10418025; Sullivan, Louis W.; Sullivan, L W 1; Source Information: 5/22/91-5/29/91, Vol. 265 Issue 20, p2652; Subject: SULLIVAN, Louis; Subject: UNITED States. Dept. of Health & Human Services; Subject: AIDS (Disease); Subject: CHILDREN; Geographic Terms: AFRICA; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Stout, Nancy
AU - Bell, Catherine
T1 - Effectiveness of Source Documents for Identifying Fatal Occupational Injuries: A Synthesis of Studies.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 725
EP - 728
PB - American Public Health Association
SN - 00900036
AB - Background: The complete and accurate identification of fatal occupational injuries among the US workforce is an important first step in developing work injury prevention efforts. Numerous sources of information, Numerous sources of information, such as death certificates, Workers' Compensation files, Occupational Safety and Health Administration (OSHA), files, medical examiner records, state health and labor department reports, and various combinations of these, have been used to identify cases of work-related fatal injuries. Recent studies have questioned the effectiveness of these sources for identifying such cases. Methods: At least 10 studies have used multiple sources to define the universe of fatal work injuries within a state and to determine the capture rates, or proportion of the universe identified, by each source. Results of these studies, which are not all available in published literature, are summarized here in a format that allows researchers to readily compare the ascertainment capabilities of the sources. Results: The overall average capture rates of sources were as follows: death certificates, 81%; medical examiner records, 61%; Workers' Compensation reports, 57%; and OSHA reports 32%. Variations by state and value added through the use of multiple sources are presented and discussed. Conclusions: This meta-analysis of 10 state-based studies summarizes the effectiveness of various source documents for capturing cases of fatal occupational injuries to help researchers make informed decisions when designing occupational injury surveillance systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Work-related injuries
KW - Accidents
KW - Disasters
KW - Workers' compensation
KW - Employers' liability
KW - Insurance
KW - Accident insurance
KW - Health insurance
KW - Social security
N1 - Accession Number: 9107224895; Stout, Nancy 1; Bell, Catherine 1; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: Jun91, Vol. 81 Issue 6, p725; Subject Term: Work-related injuries; Subject Term: Accidents; Subject Term: Disasters; Subject Term: Workers' compensation; Subject Term: Employers' liability; Subject Term: Insurance; Subject Term: Accident insurance; Subject Term: Health insurance; Subject Term: Social security; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524113 Direct Life Insurance Carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bell, Catherine A.
T1 - Female Homicides in United States Workplaces, 1980-1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 729
EP - 732
PB - American Public Health Association
SN - 00900036
AB - Background: Women, while noted for low occupational injury mortality rates, are more likely to die as victims of assault than from any other manner of injury at work. Methods: From the National Traumatic Occupational Fatality surveillance data, 950 women were identified who were fatally assaulted at work. Homicide rates were calculated for the demographic and employment characteristics of these women. Risk ratios among types of lethal injuries were examined. Results: During 1980-1985, the crude six-year workplace homicide rate was 4.0 deaths per million working women: one twentieth the homicide rate of the US female population. Decedents ranged from 16 years (the lowest age included in the data base) to 93 years of age. Working women older than 65 years had the highest age-specific homicide rate, 11.3 per million. Women younger than 20 had the lowest, 2.5 per million per year. Homicide rates for women of races other than White were nearly twice as high as those of Whites. The leading causes of death were gunshot wounds (64 percent), stabbings (19 percent), asphyxiations (7 percent), and blunt force trauma (6 percent). Nearly 43 percent of the deceased women had been employed in retail trade: 8.7 per million employed women annually. Conclusions: During 1980-1985, only 6 percent of the nation's victims of work-related injury deaths were female: 41 percent of those women were murdered. Homicide is currently the leading manner of traumatic workplace death among women in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Demography
KW - Homicide
KW - Criminal law
KW - Offenses against the person
KW - Violent deaths
KW - Women -- United States
KW - Mortality
KW - Death
KW - Gunshot wounds
N1 - Accession Number: 9107224896; Bell, Catherine A. 1; Affiliations: 1: National institute for Occupational Safety and Health, Morgantown; Issue Info: Jun91, Vol. 81 Issue 6, p729; Thesaurus Term: Demography; Subject Term: Homicide; Subject Term: Criminal law; Subject Term: Offenses against the person; Subject Term: Violent deaths; Subject Term: Women -- United States; Subject Term: Mortality; Subject Term: Death; Subject Term: Gunshot wounds; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Etherton, John R.
AU - Myers, John R.
AU - Jensen, Roger C.
AU - Russell, Julie C.
AU - Braddee, Richard W.
T1 - Agricultural Machine-Related Deaths.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 766
EP - 768
PB - American Public Health Association
SN - 00900036
AB - Analysis of 1980-1985 death certificate data for the United States indicated that an average of 369 occupational deaths per yeas involved agricultural machinery as the external cause of death. Out of all agricultural machine-related deaths, tractors accounted for 69 percent. Over half of these tractor-related deaths were, rollovers. There is a need for public health programs to effect greeter use of rollover protective structures (ROPS) on farm tractors. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural equipment
KW - Public health
KW - Machinery
KW - Farm mechanization
KW - Death
KW - Rollover protective structures (Machinery)
KW - Machinery -- Safety appliances
KW - Agricultural equipment -- Rollover protective structures
N1 - Accession Number: 9107224908; Etherton, John R. 1; Myers, John R. 1; Jensen, Roger C. 1; Russell, Julie C. 1; Braddee, Richard W. 1; Affiliations: 1: Division of Safety Research, National institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Jun91, Vol. 81 Issue 6, p766; Thesaurus Term: Agricultural equipment; Thesaurus Term: Public health; Subject Term: Machinery; Subject Term: Farm mechanization; Subject Term: Death; Subject Term: Rollover protective structures (Machinery); Subject Term: Machinery -- Safety appliances; Subject Term: Agricultural equipment -- Rollover protective structures; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417990 All other machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333999 All Other Miscellaneous General Purpose Machinery Manufacturing; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Burden, R. W.;
AU - Weaver, M. W.;
T1 - Monitoring phenytoin levels in alcoholics
CT - Monitoring phenytoin levels in alcoholics
JO - ASHP Annual Meeting
JF - ASHP Annual Meeting
Y1 - 1991/06/01/
VL - 48
IS - Jun
SP - P
EP - D
AD - United States Public Health Service Indian Hospital, 1700 Cerrillos Road, Santa Fe, NM 87501, USA
N1 - Accession Number: 28-07118; Language: English; Chemical Name: Phenytoin--57-41-0; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Metabolism and Body Distribution; Institutional Pharmacy Practice
N2 - The purpose of this study was to develop monitoring procedures for alcoholic patients that are being administered phenytoin. Many of our patients suffer from seizure disorders. When complicated by alcoholism, careful evaluation of the anti-epileptic medication and monitoring must ensue. Complications arising from pathophysiological conditions associated with alcoholism such as cirrhosis and hypoalbuminemia will potentially affect the clearance of phenytoin and result in a wide variation between clinical response and total serum concentration of the drug. In light of these changing pathophysiological conditions, the pharmacist must consider ordering free levels to evaluate the amount of free drug able to cause a response (either therapeutic or toxic) in the patient. Concomitant administration of other drugs affecting the metabolism or clearance of anti-epileptic drugs can make monitoring difficult. For example, cimetidine is often given to prevent GI bleeding in alcoholics. The interaction between cimetidine and phenytoin is well documented and elevated phenytoin levels can be seen because of this inter ction. Since ataxia and confusion are often associated with encephalopathy, the possibility of phenytoin toxicity must be ruled out before making the definitive diagnosis. If the patient is hypoalbuminemic and only total drug levels are being monitored, therapeutic levels may mislead the provider into making the wrong diagnosis. A patient developed phenytoin toxicity due to a combination of complications. The need for phenytoin in epileptic patients that have low protein binding and decreased hepatic clearance is not unusual. Monitoring procedures have been developed by the clinical pharmacy department including flow sheets and pharmacokinetic policies for use by pharmacy students, residents, and pharmacists. Inservices to the medical, nursing, pharmacy and laboratory departments have been presented to improve awareness and knowledge of anticonvulsant therapy and monitoring in the alcoholic.
KW - Phenytoin--blood levels-;
KW - ASHP meeting abstracts--phenytoin monitoring, alcoholics;
KW - Alcoholism--phenytoin--blood levels monitoring;
KW - Clinical pharmacists--monitoring--phenytoin therapy, alcoholics;
KW - Pharmacokinetics--phenytoin--alcoholics;
KW - Blood levels--phenytoin--monitoring, alcoholics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - kelley, Ingrid
AU - Pfiester, Lois A.
T1 - ULTRASTRUCTURE OF GLOEODINIUM MONTANUM (DINOPHYCEAE).
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1991/06//
VL - 27
IS - 3
M3 - Article
SP - 414
EP - 423
PB - Wiley-Blackwell
SN - 00223646
AB - The freshwater dinoflagellate Gloeodinium montanum Klebs (1912) was examined with transmission and scanning electron microscopy. Micrographs of ultrathin sections revealed a series of membrane layers rather than the usual dinoflagellate theca in vegetative cysts and in zygotes. Swarmers had distinct pellicles but appeared to be devoid of thecal plates and vesicles. The organization of cysts and swarmers appeared remarkably similar. All cell types had typical dinoflagellate nuclei with condensed chromosomes. Chloroplasts had girdle lamellae. One pyrenoid per cell was also present in chloroplasts of vegetative cysts. Starch grains and oil globules were distributed throughout the cytoplasm. Large accumulation bodies and polyvesicular vacuoles were found in aging cysts. Trichocysts and flagellar hairs were absent. Two types of intra-cellular prokaryotic organisms were discovered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dinoflagellates
KW - Microscopy
KW - Zygotes
KW - Chromosomes
KW - Dinocapsales
KW - Gloeodinium montanum
KW - Pyrrophyta
KW - ultrastructure.
N1 - Accession Number: 10767327; kelley, Ingrid 1,2; Pfiester, Lois A. 1; Affiliations: 1: Department of botany and Microbiology, University of Oklahoma.; 2: National Center for Toxicological Research, Jefferson, Arkansas.; Issue Info: Jun91, Vol. 27 Issue 3, p414; Thesaurus Term: Dinoflagellates; Subject Term: Microscopy; Subject Term: Zygotes; Subject Term: Chromosomes; Author-Supplied Keyword: Dinocapsales; Author-Supplied Keyword: Gloeodinium montanum; Author-Supplied Keyword: Pyrrophyta; Author-Supplied Keyword: ultrastructure.; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1529-8817.ep10767327
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roberts, M.
AU - Fairweather, N. F.
AU - Leininger, E.
AU - Pickard, D.
AU - Hewlett, E. L.
AU - Robinson, A.
AU - Hayward, C.
AU - Dougan, G.
AU - Charles, I. G.
T1 - Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1991/06//
VL - 5
IS - 6
M3 - Article
SP - 1393
EP - 1404
PB - Wiley-Blackwell
SN - 0950382X
AB - The Bordetella pertussis P.69 protein is an immunogen with vaccine potential. The role of this protein in pathogenesis is unclear; it has been associated with the toxic adenylate cyclase and adhesion to eukaryotic cells. For further analysis of the role of P.69 in the biology of B. pertussis , we have constructed strains which specifically lack P.69. The cloned P.69 (prn ) gene of B. pertussis was insertionatly inactivated with a kanamycin-resistance cassette. This inactivated gene was used to construct P.69- mutants of B. pertussis by allelic exchange using plasmid pRTPL1. B. pertussis P.69- strains produced normal levels of other vir -regulated factors, including adenylate cyclase. The serotype of B. pertussis , determined by Eldering and Preston typing sera and monoclonal antibodies, was also unaffected by the presence or absence of P.69. The ability of a prn mutant to adhere to and invade HEp2 cells was not significantly different from that of its parent strain. A strain containing a mutation in fhaB was significantly less adhesive and invasive than its parent, and a prn fhaB double mutant exhibited an even greater reduction in adhesiveness and invasinveness down to levels comparable with Vir- strain. However, strains harbouring mutations in FHA and/or P.69 were able to colonize or multiply in the murine respiratory tract, although a Vir- strain was unable to survive and proliferate in the same infection model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Eukaryotic cells
KW - Mutation (Biology)
KW - Proteins
KW - Bordetella pertussis
KW - Adenylate cyclase
N1 - Accession Number: 15987557; Roberts, M. 1; Fairweather, N. F. 1; Leininger, E. 2; Pickard, D. 1; Hewlett, E. L. 3; Robinson, A. 4; Hayward, C. 1; Dougan, G. 1; Charles, I. G. 1; Affiliations: 1: Department of Molecular Biology, Wellcome Biotech, Langley Court, Beckenham, Kent BR3 3BS, UK; 2: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA; 3: Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA; 4: Division of Biologics, PHLS Centre for Applied Microbiology and Research, Porton, Salisbury, Wiltshire SP4 0JG, UK; Issue Info: Jun1991, Vol. 5 Issue 6, p1393; Thesaurus Term: Eukaryotic cells; Thesaurus Term: Mutation (Biology); Subject Term: Proteins; Subject Term: Bordetella pertussis; Subject Term: Adenylate cyclase; Number of Pages: 12p; Illustrations: 3 Diagrams, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MILLER, HENRY I.
AU - BURRIS, ROBERT H.
AU - VIDAVER, ANNE K.
T1 - Regulation of Biotechnology.
JO - Science
JF - Science
Y1 - 1991/06/21/
VL - 252
IS - 5013
M3 - Article
SP - 1599
EP - 1600
SN - 00368075
N1 - Accession Number: 87437351; MILLER, HENRY I. 1; BURRIS, ROBERT H. 2; VIDAVER, ANNE K. 3; Affiliations: 1: Office of Biotechnology, Food and Drug Administration, Rockville, MD 20857; 2: Department of Biochemistry, University of Wisconsin, Madison, W 53706; 3: Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583; Issue Info: 6/21/1991, Vol. 252 Issue 5013, p1599; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grossman, David C.
AU - Milligan, Carol
AU - Deyo, Richard A.
T1 - Risk Factors for Suicide Attempts among Navajo Adolescents.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/07//
VL - 81
IS - 7
M3 - Article
SP - 870
EP - 874
PB - American Public Health Association
SN - 00900036
AB - Background: Rates of adolescent suicide in the United States are highest among Native Americans but little is known about risk factors for suicide attempts in this population. Methods: To identify risk factor self-reported suicide attempts by Navajo adolescents, we analyzed the 1988 Indian Health Service Adolescent Health Survey that was administered to 7,254 students in grades 6 through 12 on the Navajo reservation. The responses of students reporting a past suicide attempt were compared to others. Results: Nearly 15 percent (N = 971) reported a previous suicide attempt; of those admitted to more than one attempt. Controlling for age, a logistic regression model revealed the following associations with suicide attempts: a history of mental health problems (OR = 3.2); alienation from family (OR = 3.2) having a attempted suicide (OR = 2.8); weekly consumption of hard liquor (OR = 2.7); a family history of a suicide or attempt (OR = 2.3); poor self-perception of health (OR = 2.2); a history of physical abuse (OR = 1.9) female gender (OR = 1.7); and sexual abuse (OR = 1.5). Conclusions: adolescent suicide attempts in this population should target individuals with those risk factors of the highest risk and prevalence of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Suicidal behavior
KW - Suicide -- Risk factors
KW - Teenagers -- Suicidal behavior
KW - Self-destructive behavior
KW - Mental health
KW - Physical abuse
KW - Sex crimes
KW - Self-perception in adolescence
KW - United States
N1 - Accession Number: 9108050288; Grossman, David C. 1; Milligan, Carol 2; Deyo, Richard A. 3,4; Affiliations: 1: Department of Pediatrics, University of Washington, and Harborview Injury Prevention and Research Center, 325 Ninth Avenue, ZX-10, Seattle, WA 98104; 2: Maternal and Child Health Branch, Navajo Area Indian Health Service, Window Rock, AZ; 3: Department of Medicine, University of Washington and Seattle Veterans Affairs Medical Center; 4: Health Services, University of Washington and Seattle Veterans Affairs Medical Center; Issue Info: Jul1991, Vol. 81 Issue 7, p870; Subject Term: Suicidal behavior; Subject Term: Suicide -- Risk factors; Subject Term: Teenagers -- Suicidal behavior; Subject Term: Self-destructive behavior; Subject Term: Mental health; Subject Term: Physical abuse; Subject Term: Sex crimes; Subject Term: Self-perception in adolescence; Subject: United States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Li, Z. M.
AU - Hannah, J. H.
AU - Stibitz, S.
AU - Manclark, C. R.
AU - Brennan, M. J.
AU - Nguyen, N. Y.
T1 - Cloning and sequencing of the structural gene for the porin protein of Bordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1991/07//
VL - 5
IS - 7
M3 - Article
SP - 1649
EP - 1656
PB - Wiley-Blackwell
SN - 0950382X
AB - Bordetella pertussis produces a porin protein which is a prominent outer membrane component found in both virulent and avirulent strains N -terminal amino acid analysis of purified B. pertussis porin was performed and this amino acid sequence was used to design an oligonucleotide that was then utilized to screen a &lamda;gt11 library containing randomly sheared fragments of DNA from B. pertussis strain 347. One clone, &lamda;BpPor, was identified and subcloned into pUC18. A portion of the DNA insert in this subclone, pBpPor1, was sequenced and shown to contain the N-terminal region of the structural porin gene. This truncated gene sequence was used to design an additional oligonucleotide that was used to identify a clone, pBpPor2, which overlapped with pBpPor1 and contained a termination codon. The structural gene deduced from this sequence would encode a 365-amino-acid polypeptide with a predicted mass of 39103 daltons. The predicted product also contains a signal sequence of 20 residues that is similar to that found in other porin genes. The predicted B. pertussis porin protein sequence contains regions that are homologous to regions found in porins expressed byNeisseria species and Escherichia coli including the presence of phenylalanine as the carboxy-terminal amino acid. DNA hybridization studies indicated that both virulent and avirulent strains of B. pertussis contain only one copy of this gene and that Bordetella bronchiseptica and Bordetella parapertussis contain a similar gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bordetella pertussis
KW - Proteins
KW - Nucleotide sequence
KW - Genes
KW - Amino acids
KW - Oligonucleotides
KW - DNA
N1 - Accession Number: 16253534; Li, Z. M. 1; Hannah, J. H. 1; Stibitz, S. 1; Manclark, C. R. 1; Brennan, M. J. 1; Nguyen, N. Y. 2; Affiliations: 1: Division of Bacterial Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA; 2: Division of Biochemistry and Biophysics, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA; Issue Info: Jul1991, Vol. 5 Issue 7, p1649; Subject Term: Bordetella pertussis; Subject Term: Proteins; Subject Term: Nucleotide sequence; Subject Term: Genes; Subject Term: Amino acids; Subject Term: Oligonucleotides; Subject Term: DNA; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 8p; Illustrations: 4 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Garza, Alvaro
AU - Mutchinick, Osvtddo
AU - Cordero, Jose F.
AU - Burse, Virfyn W.
T1 - International Collaboration in a Cluster Investigation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/08//
VL - 81
IS - 8
M3 - Letter
SP - 1077
EP - 1078
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented about the investigation of an alleged cluster of children with facial malformations in 1987 in Matamoros, Mexico by the Mexican National Institute of Nutrition, the Pan American Health Organization and the U.S. Centers for Disease Control.
KW - Letters to the editor
KW - Facial abnormalities
N1 - Accession Number: 20671838; Garza, Alvaro 1; Mutchinick, Osvtddo 2; Cordero, Jose F. 3; Burse, Virfyn W. 3; Affiliations: 1: Pan American Health Organization of the World Health Organization in Metepec, Mexico; 2: Instituto Nacional de la Nutricion Salvador Zubiran in Tlalpan, Mexico; 3: Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga; Issue Info: Aug1991, Vol. 81 Issue 8, p1077; Subject Term: Letters to the editor; Subject Term: Facial abnormalities; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Puri, R. K.
AU - Leland, P.
T1 - In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1991/08//
VL - 85
IS - 2
M3 - Article
SP - 317
EP - 325
SN - 00099104
AB - Interferon-alpha (IFN-α) has been shown to synergize with IL-2 in the regression of a variety of established murine tumours and studies are underway to explore this combination in patients with advanced cancers as well. To understand the mechanism of synergy we have studied lymphokine- activated killer (LAK) cell activity in various compartments of mice in response to IFN-α and IL-2 administration. The effects of IFN-γ TNF-α and IL-4 were also examined. C57BL/6 mice were injected intraperitoneally with HBSS, IL-2 alone, IFN-α alone or both, two times a day for 7 days. On days 4 and 8, LAK activity was tested in a 4-h chromium release in cells obtained from lungs, spleen, and liver using fresh MCA-102 tumour cells as targets. The cells from control mice failed to lyse the MCA-102 target. IL-2 caused the generation of LAK activity and an increase in total cell yield in all the organs after 3 days of injection. IFN-α failed to generate LAK activity but when administered along with IL-2, caused synergistic enhancement of LAK lysis of MCA-102 target cells. Cell yield in this group was lower as compared with the IL-2-treated group. LAK activity tested after 7 days of IL-2 therapy was significantly decreased compared with that observed after 3 days. However, activity remained at as high a level after 7 days of therapy as after 3 days of therapy in animals treated with IFN-α and IL-2. FACS analysis revealed that asialo GM-1+ (ASGM-1) and NK1.1+ cells were increased in number in IL-2 and IL-2 plus IFN-α-treated spleen; however, the number of these cells was similar in both groups. In the liver, ASGM-1+ cells were higher in the IL-2 plus IFN-α group than in the group treated with IL-2 alone. By in vitro depletion utilizing antibody and Rbc' experiments, it was clear that both ASGM-1+ and NK 1.1+ cells from the spleen mediated most of the cytotoxicity of MCA-102 targets. Pre-treatment irradiation (5 Gy) of mice completely abrogated the capability of IL-2 or IL-2 plus IFN-α to generate LAK activity. IFN-α also had a stimulatory effect on IL-2 induction of LAK activity. Tumour necrosis factor-alpha (TNF-α) and IL-4 failed to generate LAK activity and, in combination with IL-2, no additional stimulatory effect was observed. These studies indicate that induction of LAK activity may be at least partly responsible in the mediation of synergistic anti-tumour effects of IFN-α and IL-2 or IFN-γ and IL-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - TUMORS
KW - CANCER patients
KW - LYMPHOKINES
KW - KILLER cells
KW - TUMOR necrosis factor
KW - cytotoxic lymphocytes
KW - in vivo therapy
KW - LAK cells
N1 - Accession Number: 16173485; Puri, R. K. 1; Leland, P. 1; Source Information: Aug1991, Vol. 85 Issue 2, p317; Subject: INTERFERONS; Subject: TUMORS; Subject: CANCER patients; Subject: LYMPHOKINES; Subject: KILLER cells; Subject: TUMOR necrosis factor; Author-Supplied Keyword: cytotoxic lymphocytes; Author-Supplied Keyword: in vivo therapy; Author-Supplied Keyword: LAK cells; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Patterson, Gregory M.L.
AU - Baldwin, Cynthia L.
AU - Boils, Christine M.
AU - Caplan, Faith R.
AU - Karuso, Helen
AU - Larsen, Linda K.
AU - Levine, Ira A.
AU - Moore, Richard E.
AU - Nelson, Carrie S.
AU - Tschappat, Kathryn D.
AU - Taung, Grace D.
AU - Furusawa, Eiichi
AU - Furusawa, Shinobu
AU - Norton, Ted R.
AU - Raybourne, Richard B.
T1 - ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE-GREEN ALGAE (CYANOPHYTA).
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1991/08//
VL - 27
IS - 4
M3 - Article
SP - 530
EP - 536
PB - Wiley-Blackwell
SN - 00223646
AB - A large-scale screening program was initiated to evaluate laboratory-cultured blue-algae (cyanobacteria) as a source of novel antineoplastic agents. Approximately 1000 cyanophyte strains from divers habitats were cultured to provide extracts for testing. The screening program identified the families Scytonemataceae and Stigonemataceae as prolific producers of novel cytotoxic compounds. Rates of rediscovery of known compound were relatively low. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cyanobacteria
KW - Microalgae
KW - Natural products
KW - Drugs
KW - Antineoplastic agents
KW - Cell culture
KW - anticancer
KW - cyanobacteria
KW - microalgae
KW - natural products
KW - pharmaceutical
N1 - Accession Number: 10767477; Patterson, Gregory M.L. 1; Baldwin, Cynthia L. 1; Boils, Christine M. 1; Caplan, Faith R. 1; Karuso, Helen 1; Larsen, Linda K. 1; Levine, Ira A. 1; Moore, Richard E. 1; Nelson, Carrie S. 1; Tschappat, Kathryn D. 1; Taung, Grace D. 1; Furusawa, Eiichi 2; Furusawa, Shinobu 2; Norton, Ted R. 2; Raybourne, Richard B. 3; Affiliations: 1: Department of Chemistry, University of Hawaii, Honolulu, Hawaii 96822.; 2: Department of Pharmacology, University of hawaii, Honolulu, hawaii 96822.; 3: Division of Microbiology, U.S. Food and Drug Administration, 200 C. Street S.W. Washington, D.C. 20204.; Issue Info: Aug91, Vol. 27 Issue 4, p530; Thesaurus Term: Cyanobacteria; Thesaurus Term: Microalgae; Thesaurus Term: Natural products; Thesaurus Term: Drugs; Subject Term: Antineoplastic agents; Subject Term: Cell culture; Author-Supplied Keyword: anticancer; Author-Supplied Keyword: cyanobacteria; Author-Supplied Keyword: microalgae; Author-Supplied Keyword: natural products; Author-Supplied Keyword: pharmaceutical; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1529-8817.ep10767477
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107269258
T1 - FDA regulation of transplantation... proceedings from the Annual Meeting of the Division of Organ Transplantation from the February 1991 meeting held in Washington, DC.
AU - Weixel J
Y1 - 1991/08//1991 Aug
N1 - Accession Number: 107269258. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - United States Food and Drug Administration
KW - Government Regulations
KW - Transplantation -- Legislation and Jurisprudence -- United States
KW - Tissue Transplantation -- Equipment and Supplies
KW - United States
SP - 103
EP - 104
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 1
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Food and Drug Administration, Rm 11-44 Park Lawn Bldg, 5600 Fisher Lane, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Athey, Jean L.
T1 - HIV Infection and Homeless Adolescents.
JO - Child Welfare
JF - Child Welfare
Y1 - 1991/09//Sep/Oct91
VL - 70
IS - 5
M3 - Article
SP - 517
EP - 528
PB - Child Welfare League of America
SN - 00094021
AB - This article analyzes the risks for homeless adolescents of acquiring HIV infection and the service initiatives for meeting the challenges these adolescents. Data from several community surveys and youth shelters have suggested that around one and 1.3 million adolescents are in emergency shelters or on the streets in any given year. Workers who work closely with homeless youths reported high levels of sexual activity between them, some of them have it as voluntarily and some not. The sexual activity among themselves could lead to HIV infection. The sexual activity of these young people can be classified in three ways such as rape, survival sex or a love relationship.
KW - HOMELESS persons
KW - HIV infections
KW - SEXUAL intercourse
KW - HOMELESSNESS
KW - SOCIAL surveys
KW - DATA analysis
KW - INTERPERSONAL relations
KW - LENTIVIRUS diseases
N1 - Accession Number: 9110071887; Athey, Jean L. 1; Source Information: Sep/Oct91, Vol. 70 Issue 5, p517; Subject: HOMELESS persons; Subject: HIV infections; Subject: SEXUAL intercourse; Subject: HOMELESSNESS; Subject: SOCIAL surveys; Subject: DATA analysis; Subject: INTERPERSONAL relations; Subject: LENTIVIRUS diseases; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 4826
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107481362
T1 - Microbial growth and endotoxin production in the intravenous anesthetic propofol.
AU - Arduino MJ
AU - Bland LA
AU - McAllister SK
AU - Aguero SM
AU - Villarino ME
AU - McNeil MM
AU - Jarvis WR
AU - Favero MS
Y1 - 1991/09//1991 Sep
N1 - Accession Number: 107481362. Language: English. Entry Date: 19920301. Revision Date: 20150712. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Anesthesia, Intravenous
KW - Propofol
KW - Bacterial Contamination
KW - Endotoxins
KW - Drug Combinations
KW - United States
KW - Disease Outbreaks
KW - Surgical Wound Infection
KW - Gram-Negative Bacteria
KW - Gram-Positive Bacteria
KW - Microbiological Techniques
KW - Staphylococcus Aureus
KW - Candida
KW - Inpatients
KW - Infection Control -- Methods
KW - Human
SP - 535
EP - 539
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 12
IS - 9
PB - Cambridge University Press
AB - OBJECTIVE: In this study, we measured microbial growth and endotoxin production in the intravenous anesthetic propofol using 10 different microbial strains; 6 isolated from outbreak cases and 4 from laboratory stock cultures. DESIGN: In each trial, endotoxin-free glass tubes containing 10 ml propofol were inoculated with 10 to 0--10 to 3 CFU/ml of the test organism and incubated at 30 degrees C for 72 hours. SETTING: In May and June 1990, the Centers for Disease Control received reports of 5 out-breaks in 5 states of postsurgical patient infections and/or pyrogenic reactions. Epidemiologic and laboratory investigations implicated extrinsic contamination of an intravenous anesthetic, propofol, as the probable source of these outbreaks. RESULTS: After 24 hours, 9 of the 10 cultures increased in viable counts by 3 to 6 logs. At least 1 ng/ml of endotoxin was produced within 24 hours by Escherichia coli, Enterobacter cloacae, and Acinetobacter calcoaceticus subspecies anitratus. CONCLUSIONS: Propoful can support rapid microbial growth and endotoxin production. To avoid infectious complications, scrupulous aseptic technique should be used when preparing or administering this anesthetic.
SN - 0899-823X
AD - Hosp Infections Program, Ctr Infectious Diseases, Ctr Disease Control, Public Health Service, United States Dept Health Human Services, Atlanta GA
U2 - PMID: 1940276.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Desenclos, Jean-Claude A.
AU - Klontz, Karl C.
AU - Wilder, Michael H.
AU - Nainan, Omana V.
AU - Margolis, Harold S.
AU - Gunn, Robert A.
T1 - A Multistate Outbreak of Hepatitis A Caused by the Consumption of Raw Oysters.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/10//
VL - 81
IS - 10
M3 - Article
SP - 1268
EP - 1272
PB - American Public Health Association
SN - 00900036
AB - Background. In August 1988 we investigated a multistate outbreak of hepatitis A caused by Panama City, Florida, raw oysters. Methods. Cases of hepatitis A (HA) with onset in July-August 1988 were identified among persons who ate seafoods harvested in the coastal waters of Panama City, Florida. We conducted a case-control study, using eating companions of case-patients, and calculated attack rate (AR) per 1000 dozen raw oysters served. Enzyme immunoassay (EIA) and a polymerase chain reaction (PCR) technique were performed on samples of raw shellfish obtained from Panama City coastal waters. Results. Sixty-one case-patients were identified in five states: Alabama (23), Georgia (18), Florida (18), Tennessee (1), and Hawaii (1). We found an increased risk of HA for raw oyster eaters (odds ratio = 24.0; 95% confidence interval = 5.4-215.0; P < .001). The AR of HA in seafood establishments was 1.9/1000 dozen raw oysters served. The EIA and PCR revealed HA virus antigen and nucleic acid in oysters from both unapproved and approved oyster beds, in confiscated illegally harvested oysters, and in scallops from an approved area. Conclusions. The monitoring of coastal waters and the enforcement of shellfish harvesting regulations were not adequate to protect raw oyster consumers. More emphasis should be placed on increasing public awareness of health hazards associated with eating raw shellfish. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Oysters
KW - Hepatitis A
KW - Raw foods
KW - Enzyme-linked immunosorbent assay
KW - Polymerase chain reaction
KW - Panama City (Fla.)
KW - Florida
N1 - Accession Number: 9112090809; Desenclos, Jean-Claude A. 1; Klontz, Karl C. 2; Wilder, Michael H. 2; Nainan, Omana V. 3; Margolis, Harold S. 3; Gunn, Robert A. 1; Affiliations: 1: Division of Field Epidemiology, Centers for Disease Control, Public Health Service, Atlanta; 2: Disease Control, Florida Department of Health and Rehabilitative Services, Tallahassee, Fla.; 3: Hepatitis Branch, Centers for Disease Control, Public Health Service, Atlanta; Issue Info: Oct91, Vol. 81 Issue 10, p1268; Thesaurus Term: Epidemics; Thesaurus Term: Oysters; Subject Term: Hepatitis A; Subject Term: Raw foods; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Polymerase chain reaction; Subject: Panama City (Fla.); Subject: Florida; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Britt, A L
AU - Anello, C
AU - Perry, Z A
T1 - Completeness of adverse drug experience reporting by manufacturers to the FDA
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1991/10//
VL - 23
IS - 4
M3 - Article
SP - 599
EP - 606
SN - 00928615
AB - This project evaluated the completeness of manufacturer adverse drug experience (ADE) reports on computerized fields on the FDA-1639 form for which completion is not required for data entry, (e.g., age, sex, ADE onset date). The completion rate of such fields was determined for domestic, spontaneous, health professional-submitted ADE reports during 1986-1989. This project was limited to 20 manufacturers submitting the largest number of reports. Completion rates were computed for total reports and 15-day reports. A completion rate was defined for each field for each manufacturer as the number of times the field was filled in divided by the total number of reports. In general, the completion rate was higher for 15-day reports than total reports. Because there were manufacturers with > or = 90% completion rates, other manufacturers should concentrate on improving their completion rates. Consideration should be given to 15-day reports; they are used by FDA in the signaling of monitored adverse reactions.
KW - EVALUATION
KW - Drug information
KW - Federal government
KW - Information management
N1 - Accession Number: ISTA2700330; Britt, A L 1; Anello, C; Perry, Z A; Affiliations: 1 : Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD; Source Info: Oct 1991, Vol. 23 Issue 4, p599; Note: Update Code: 2700; Subject Term: EVALUATION; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Author-Supplied Keyword: Information management; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 107483638
T1 - Measles immunity among community hospital employees.
AU - Houck P
AU - Scott-Johnson G
AU - Krebs L
Y1 - 1991/11//1991 Nov
N1 - Accession Number: 107483638. Language: English. Entry Date: 19920401. Revision Date: 20150712. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Personnel, Health Facility
KW - Hospitals, Community -- Manpower
KW - Measles -- Epidemiology
KW - Immunity -- Evaluation
KW - Disease Outbreaks -- Prevention and Control
KW - Washington
KW - Epidemiological Research
KW - Measles Vaccine -- Therapeutic Use
KW - Prospective Studies
KW - Chi Square Test
KW - Immunosorbent Techniques
KW - Comparative Studies
KW - Questionnaires
KW - Antibodies, Viral -- Analysis
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Human
SP - 663
EP - 668
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 12
IS - 11
PB - Cambridge University Press
AB - Objective: To define measles immunity rates among employees at 2 hospitals during a community outbreak in 1990. Design: Cohort survey using enzyme-linked immunosorbant assay (ELISA) and questionnaire. Setting: Two community hospitals. Participants: Seventy-six percent of 2,060 employees. Results: Seven percent (115/1566) of participants lacked ELISA-defined measles immunity. Among employees whose ages were known, 14% (64/467) of those born after 1956 and 5% (50/1086) of those born before 1957 lacked serologic evidence of immunity. Fifty-eight percent of the susceptible persons had substantial patient contact. With ELISA results as the reference for immunity, the predictive value of an undocumented positive history of measles disease or vaccination was 95%; the predictive value of a negative history of both was 52%. Measles developed in 7 employees. Conclusions: A substantial number of hospital employees lacked ELISA-defined measles immunity, including many who had patient contact or who had been born before 1957. Undocumented disease and vaccination histories were not adequate predictors of serologic status. This study supports the recommendations and suggestions of the Immunization Practices Advisory Committee that hospitals should require documented evidence of measles immunity from employees who have patient contact.
SN - 0899-823X
AD - Indian Health Service Room 300, 2201 6th Ave, Seattle, WA 98121
U2 - PMID: 1753081.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107482431
T1 - The Human Genome Initiative -- implications for nurse researchers.
AU - Abdellah FG
Y1 - 1991/11//1991 Nov-Dec
N1 - Accession Number: 107482431. Language: English. Entry Date: 19920401. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - DNA -- Analysis
KW - Genes
KW - Research
KW - Genetic Techniques
KW - Ethics
KW - Hereditary Diseases
SP - 332
EP - 332
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 7
IS - 6
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 8755-7223
AD - United States Public Health Service, Dept Health Human Services, Washington DC 20201
U2 - PMID: 1765613.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1992-21028-001
AN - 1992-21028-001
AU - Steele, William
AU - Hazelton, Michael
T1 - Perceptions and marketing positioning in nonprofit agencies.
T3 - Marketing in mental health services
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 1991/11//
VL - 19
IS - 2
SP - 81
EP - 92
CY - Germany
PB - Springer
SN - 0894-587X
N1 - Accession Number: 1992-21028-001. Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Steele, William; New Center Community Mental Health Services, Community Services, Detroit, MI, US. Release Date: 19920601. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Marketing; Mental Health Services; Nonprofit Organizations. Minor Descriptor: Videotapes. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 12. Issue Publication Date: Nov, 1991.
AB - Describes the informal marketing approaches of a large nonprofit mental health services agency that successfully positioned itself to market educational videos for use in schools. The agency evaluated competition and used existing positive perceptions to create a position in the educational market by developing products to meet both the needs and wants of consumers. Successful marketing of products in this field includes effective promotions and advertising, as well as creating positive perceptions, which, in turn, will create strong market positions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perceptions & positioning in marketing educational videos for school use
KW - large nonprofit mental health services agency
KW - 1991
KW - Marketing
KW - Mental Health Services
KW - Nonprofit Organizations
KW - Videotapes
KW - 1991
DO - 10.1007/BF00706421
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Russell, Julie
AU - Conroy, Carol
T1 - Representativeness of Deaths Identified Through the Injury-at-Work Item on the Death Certificate: Implications for Surveillence.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/12//
VL - 81
IS - 12
M3 - Article
SP - 1613
EP - 1613
PB - American Public Health Association
SN - 00900036
AB - Background. This research investigated the accuracy of the injury-at-work item on the death certificate for surveillance of occupational injury deaths in Oklahoma during 1985 and 1986. Methods. Representativeness of occupational injury deaths identified by death certificates was assessed by comparing these deaths with all occupational injury deaths identified through death certificates, workers' compensation reports, medical examiner reports, and OSHA records for categories of occupation, industry, and external causes of death. Results. Certain external causes of death (e.g., motor vehicle traffic deaths) and certain occupations (e.g., fanning) and industries (agriculture and services) are more often underidentified through death certificates. Conclusions. The findings of this study support Baker's observation that no single data source contains all deaths or all the data elements necessary to describe occupational injury deaths. Data sources may be combined to improve representativeness through more complete case ascertainment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLASSIFICATION
KW - Work-related injuries
KW - Death
KW - CAUSES
KW - Occupational mortality
KW - Death -- Proof & certification
KW - Death certificates
KW - Workers' compensation
KW - Occupations
KW - Accidents
KW - United States
N1 - Accession Number: 9202101749; Russell, Julie 1,2; Conroy, Carol 1,3; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WVa; 2: Division of Injury Control, Centers for Disease Control, Atlanta; 3: California Occupational Health Program, Berkeley; Issue Info: Dec1991, Vol. 81 Issue 12, p1613; Thesaurus Term: CLASSIFICATION; Subject Term: Work-related injuries; Subject Term: Death; Subject Term: CAUSES; Subject Term: Occupational mortality; Subject Term: Death -- Proof & certification; Subject Term: Death certificates; Subject Term: Workers' compensation; Subject Term: Occupations; Subject Term: Accidents; Subject: United States; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 6p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Rastogi, S. C.;
AU - Hayes, S. W.;
AU - Goetsch, R. A.;
AU - Nazario, J.;
T1 - Reporting of adverse experiences to childhood immunizations
CT - Reporting of adverse experiences to childhood immunizations
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1991/12/01/
VL - 26
IS - Dec
SP - PI
EP - 56
AD - Division of Biostatistics and Epidemiology, CBER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
N1 - Accession Number: 29-00341; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Adverse Drug Reactions; Information Processing and Literature
N2 - Food and Drug Administration (FDA) licensure requires that vaccines and toxoids be extensively tested for immunogenicity, safety, and efficacy prior to marketing. It is only after a vaccine becomes widely available and is used in standard clinical practice, that a more accurate profile of the types and frequencies of adverse experiences evolves. A postmarketing surveillance of vaccines is necessary to evaluate the benefits and risks of immunization, so that vaccine safety can be optimized and policies can be developed which maximize the beneficial impact of the vaccine. The Vaccine Adverse Event Reporting System (VAERS) which is mandated by the National Childhood Vaccine Injury Act of 1986 became operational on November 1, 1990. VAERS is a postmarketing surveillance system, providing a mechanism to report all suspected adverse events occurring after the administration of any vaccine to children and adults. The Division of Biostatistics and Epidemiology of the Center for Biologics Evaluation and Research (CBER) at the FDA conducts routine analyses on the VAERS database. The purpose of these analyses is to estimate incidence rates on previously unreported adverse events, detect trends and clustering, and determine an accurate profile of adverse events. The use of aggregate data and follow-up studies to identify vaccine-associated adverse events should reduce health care providers concerns that a single report of a potential adverse event will result in regulatory action or litigation.
KW - ASHP meeting abstracts--vaccines adverse reactions reporting;
KW - Vaccines--toxicity--reports;
KW - Drugs, adverse reactions--vaccines--reports;
KW - Reports--drugs, adverse reactions--vaccines;
KW - Pediatrics--vaccines--adverse reactions, reports;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Mason, James O.
T1 - Protecting Physicians From Vaccine Liability.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/12/04/
VL - 266
IS - 21
M3 - Article
SP - 2951
EP - 2951
SN - 00987484
AB - Discusses the U.S. Vaccine Injury Compensation Program which was created in the National Childhood Vaccine Injury Act of 1986. Standards for tort actions alleging injury from diphtheria, tetanus, pertussis and polio vaccines; Filing of vaccine injury claims; Eligibility of compensation through the program.
KW - MEDICAL care
KW - VACCINES
KW - THERAPEUTICS
KW - UNITED States
N1 - Accession Number: 10980282; Mason, James O. 1; Source Information: 12/4/91, Vol. 266 Issue 21, p2951; Subject: MEDICAL care; Subject: VACCINES; Subject: THERAPEUTICS; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - CHAP
ID - 1992-97455-009
AN - 1992-97455-009
AU - Suater, Steven L.
ED - Keita, Gwendolyn Puryear
ED - Sauter, Steven L.
ED - Keita, Gwendolyn Puryear, (Ed)
ED - Sauter, Steven L., (Ed)
T1 - Introduction to the NIOSH proposed national strategy.
T2 - Work and well-being: An agenda for the 1990s.
Y1 - 1992///
SP - 11
EP - 16
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-153-1
N1 - Accession Number: 1992-97455-009. Partial author list: First Author & Affiliation: Suater, Steven L.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 19921001. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-153-1, Paperback. Language: English. Conference Information: APA/NIOSH Conference: Work and Well-Being: An Agenda for the 1990s, US. Conference Note: Presented at the aforementioned conference. Major Descriptor: Health; Occupational Stress. Minor Descriptor: Strategies. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 6.
AB - Occupational stress is emerging as one of the principal social and occupational health concerns of the 1990s. In response to this concern, NIOSH has developed a multipoint strategy for control of stress in the workplace, and now APA and NIOSH have joined forces in a national meeting to translate this strategy into practical action steps. Before highlighting the key provisions of the NIOSH strategy, however, I would like to provide some background on events of the 1980s that combined to make job stress such an important issue today. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - occupational health
KW - occupational stress
KW - national strategy
KW - job stress
KW - 1992
KW - Health
KW - Occupational Stress
KW - Strategies
KW - 1992
DO - 10.1037/10108-009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1992-97455-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1993-07220-001
AN - 1993-07220-001
AU - Gregory, Delores
T1 - Much remains to be done.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1992///
VL - 4
IS - 3
SP - 89
EP - 94
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1993-07220-001. PMID: 1504179 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Gregory, Delores; Indian Health Service, Portland Area Office, OR, US. Release Date: 19930201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Alcohol Abuse; American Indians; Drug Dependency; Policy Making; Public Health. Minor Descriptor: Prevention. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Page Count: 6. Issue Publication Date: 1992.
AB - Believes that P. May (see record [rid]1993-07238-001[/rid]) presents a competent discussion of the major considerations attending morbidity and mortality associated with alcoholism on Indian reservations in the US. However, this article is more applicable to the pre-1985 period. Since then, the profile of chemical dependency in Indian country has changed due to a proliferation of substances ranging from black tar heroin to designer drugs, often used intravenously. The sexual promiscuity associated with alcohol abuse and the risks associated with needle sharing place drinkers and druggers at risk for AIDS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - profile of chemical dependency & public health policy for prevention of alcohol abuse
KW - Native American communities
KW - commentary
KW - 1992
KW - Alcohol Abuse
KW - American Indians
KW - Drug Dependency
KW - Policy Making
KW - Public Health
KW - Prevention
KW - 1992
DO - 10.5820/aian.0403.1990.89
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DP - EBSCOhost
DB - psyh
ER -
TY - CONF
ID - 1992-98188-000
AN - 1992-98188-000
AU - Quick, James Campbell
AU - Murphy, Lawrence R.
AU - Hurrell, Joseph J. Jr.
ED - Quick, James Campbell
ED - Murphy, Lawrence R.
ED - Hurrell, Joseph J. Jr.
T1 - Stress & well-being at work: Assessments and interventions for occupational mental health.
Y1 - 1992///
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-175-2
N1 - Accession Number: 1992-98188-000. Partial author list: First Author & Affiliation: Quick, James Campbell; Department of Management, University of Texas at Arlington, Arlington, TX, US. Release Date: 19930201. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Conference Proceedings. ISBN: 1-55798-175-2, Paperback. Language: English. Major Descriptor: Mental Health; Occupational Stress. Minor Descriptor: Prevention; Stress Management. Classification: Promotion & Maintenance of Health & Wellness (3365); Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 372.
AB - The second of two volumes to result from a national conference on work and well-being cosponsored by the APA [American Psychological Association] and the National Institute for Occupational Safety and Health, this book investigates one of the most pivotal issues in the field of occupational mental health. Authors with backgrounds ranging from research to practice identify and analyze factors that contribute to and indicate stress among employees. With an eye to productivity and workplace constraints, they then document and discuss methods of both stress management and prevention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - discusses well-being in the workplace & indicates & analyzes factors that contribute to occupational stress
KW - 1992
KW - Mental Health
KW - Occupational Stress
KW - Prevention
KW - Stress Management
KW - 1992
DO - 10.1037/10116-000
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Prentice, Andrew M.
AU - Sonko, Bakary J.
AU - Goldberg, Gail R.
AU - Murgatroyd, Peter R.
AU - Lands, William E. M.
AU - Zakhari, Sam
AU - Colditz, G. A.
AU - Giovannucci, E.
AU - Stampfer, E. B. Rimm M. J.
AU - Rosner, B.
AU - Speizer, F. E.
AU - Willett, W. C.
T1 - The case of the missing calories revisited.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1992/02//
VL - 55
IS - 2
M3 - Letter to the Editor
SP - 478
EP - 480
SN - 00029165
AB - A letter to the editor is presented in response to a article related to alcohol intake in relation to diet and obesity in women and men by G. A. Colditz and others published in a 1991 issue of the periodical.
KW - Alcohol -- Physiological effect
KW - Obesity
N1 - Accession Number: 94402189; Prentice, Andrew M. 1; Sonko, Bakary J. 1; Goldberg, Gail R. 1; Murgatroyd, Peter R. 1; Lands, William E. M. 2; Zakhari, Sam 2; Colditz, G. A. 3; Giovannucci, E.; Stampfer, E. B. Rimm M. J.; Rosner, B.; Speizer, F. E.; Willett, W. C.; Affiliations: 1: MRC Dunn Clinical Nutrition Centre, 100 Tennis Court Road, Cambridge, CB2 1Q1, UK; 2: Division of Basic Research, National Institute on Alcohol Abuse and Alcoholism Alcohol, Drug Abuse and Mental Health Administration Public Health Service, Department of Health and Human Services Rockville, MD 20857; 3: Channing Laboratory, Department of Medicine Brigham and Women's Hospital, Harvard Medical School, 180 Longwood Avenue, Boston, MA 021 15-5899; Issue Info: Feb1992, Vol. 55 Issue 2, p478; Subject Term: Alcohol -- Physiological effect; Subject Term: Obesity; Number of Pages: 3p; Document Type: Letter to the Editor
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Doll, Lynda S.
AU - Petersen, Lyle R.
AU - White, Carol R.
AU - Johnson, Eric S.
AU - Ward, John W.
T1 - Homosexually and Nonhomosexually Identified Men Who Have Sex With Men: A Behavioral Comparison.
JO - Journal of Sex Research
JF - Journal of Sex Research
Y1 - 1992/02//
VL - 29
IS - 1
M3 - Article
SP - 1
EP - 14
PB - Routledge
SN - 00224499
AB - From January 1988 to September 1989, 209 HIV-1 seropositive male blood donors who reported sex with men were interviewed at 20 U.S. blood centers. Most (59%) were Black or Hispanic and self-identified as bisexual (30%) or heterosexual (25%). During the year before their last donation, 73% of homosexually, 62% of bisexually, and 29% of heterosexually identified men had engaged in unprotected anal sex with men. Overall, few had ties to gay communities; however; 24% of bisexually and 58% of heterosexually identified men had female primary partners. There were no racial/ethnic differences in gender of partners in the last year, although Blacks were more likely to identify themselves as bisexual (44%) and Hispanics as heterosexual (34%). These data suggest the need to target prevention efforts at men having unprotected sex with male or female partners, regardless of sexual identity, and to examine social network and cultural influences affecting sexual behavior and sexual identity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Sex Research is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEN -- Sexual behavior
KW - GAY people -- Sexual behavior
KW - HIV-positive persons
KW - HETEROSEXUALS
KW - GAY community
KW - HUMAN sexuality
KW - AIDS
KW - bisexuality
KW - blood donors.
KW - homosexuality
KW - human immunodeficiency virus
N1 - Accession Number: 9609130369; Doll, Lynda S. 1; Petersen, Lyle R. 1; White, Carol R. 1; Johnson, Eric S. 1; Ward, John W. 1; Source Information: Feb92, Vol. 29 Issue 1, p1; Subject: MEN -- Sexual behavior; Subject: GAY people -- Sexual behavior; Subject: HIV-positive persons; Subject: HETEROSEXUALS; Subject: GAY community; Subject: HUMAN sexuality; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: bisexuality; Author-Supplied Keyword: blood donors.; Author-Supplied Keyword: homosexuality; Author-Supplied Keyword: human immunodeficiency virus; Number of Pages: 14p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 5317
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Czaja, Ronald F.
AU - Trunzo, Deborah H.
AU - Royston, Patricia N.
T1 - Response Effects in a Network Survey.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1992/02//
VL - 20
IS - 3
M3 - Article
SP - 340
SN - 00491241
AB - A reverse record check study was conducted to measure the response effects in a network survey designed to locate a rare population subgroup. In this field experiment, diagnosed cancer patients and certain specified relatives were interviewed using a survey instrument based on the National Health Interview Survey questionnaire and a supplemental set of questions designed to identify persons with cancer. The measurement errors associated with obtaining reports on cancer diagnosis and the date of diagnosis' are presented. In general, high rates of patient identification were found in both patient and relative households; in only 6% of the patient-relative pairs was the patient not reported. Females and Whites were more likely to be reported than males and non-Whites. A significant amount of variation and error in reporting date of diagnosis was found for both the patient and the relative households. Contrary to expectations, most households were likely to backward rather than to forward telescope the date of diagnosis. Suggestions on how to deal with error due to memory factors are proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methods & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - NETWORK analysis (Social sciences)
KW - CANCER patients
KW - CANCER -- Diagnosis
KW - SOCIAL networks
KW - FIELD work (Sociology)
KW - HOUSEHOLD surveys -- Response rate
N1 - Accession Number: 5819475; Czaja, Ronald F. 1; Trunzo, Deborah H. 2; Royston, Patricia N. 3; Source Information: Feb92, Vol. 20 Issue 3, p340; Subject: HEALTH surveys; Subject: NETWORK analysis (Social sciences); Subject: CANCER patients; Subject: CANCER -- Diagnosis; Subject: SOCIAL networks; Subject: FIELD work (Sociology); Subject: HOUSEHOLD surveys -- Response rate; Number of Pages: 27p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Sartori, A.
AU - Roque-Barreira, M. C.
AU - Coe, J.
AU - Campos-Neto, A.
T1 - Immune complex glomerulonephritis in experimental kala--azar II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1992/03//
VL - 87
IS - 3
M3 - Article
SP - 386
EP - 392
SN - 00099104
AB - In a previous report analysing kidney sections by immunofluorescence we showed that hamsters infected with L. donovani develop a glomerulonephritis (GN) associated with deposition of hamster immunoglobulins and parasite antigens in the glomeruli. In this study we characterize these immune components eluted from the kidneys. The eluted immunoglobulins showed specificity for L. donovani antigens and hamster immunoglobulins (rheumatoid (actor-like activity). The four isotypes IgG1, IgG2, IgA and IgM were detected. Several L. donovani antigens were detected in the renal eluates by Western blot and immuneprecipitation using 125I-labelled eluates. Proteins with mol, wt of 134. 82, 52. 31. and 26 kD were detected by Western blot and proteins with 134. 110, 93, 89 and 48 kD were detected by immunoprecipitation. With the exception of the 134 kD protein which was recognized by both rabbit anti-protnastigote and rabbit anti-amastigote sera all the others were recognized only by the anti-amastigote serum. The 134 kD protein was the only one isolated from the kidneys of infected hamster immunocomplexed with IgG and was the only one detected in a promastigote lysate using IgG from L. donovani-infected hamsters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOFLUORESCENCE
KW - IMMUNOGLOBULINS
KW - RHEUMATOID arthritis
KW - ANTIGENS
KW - IMMUNITY
KW - AGGLUTINATION
KW - experimental kala-azar immune complexes
KW - glomerulonephritis
KW - Leishmania donovani
N1 - Accession Number: 16075014; Sartori, A. 1; Roque-Barreira, M. C. 1; Coe, J. 2; Campos-Neto, A. 1; Source Information: Mar1992, Vol. 87 Issue 3, p386; Subject: IMMUNOFLUORESCENCE; Subject: IMMUNOGLOBULINS; Subject: RHEUMATOID arthritis; Subject: ANTIGENS; Subject: IMMUNITY; Subject: AGGLUTINATION; Author-Supplied Keyword: experimental kala-azar immune complexes; Author-Supplied Keyword: glomerulonephritis; Author-Supplied Keyword: Leishmania donovani; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Liang, S.-M.
AU - Lee, N.
AU - Finbloom, D.S.
AU - Liang, C.-M.
T1 - Regulation by glutathione of interleukin-4 activity on cytotoxic T cells.
JO - Immunology
JF - Immunology
Y1 - 1992/03//
VL - 75
IS - 3
M3 - Article
SP - 435
EP - 440
SN - 00192805
AB - We have previously shown that cellular glutathione (GSH) regulates the T-cell proliferative activity of interleukin-2 (IL-2). Here, we examined whether and how GSH affects the activity of interleukin-4 (IL-4) on murine cytotoxic T cells. CT.4R, a T-cell line that is responsive to both IL-4 and IL-2, was used as a model Although GSH alone had little effect on the thymidine incorporation of CT.4R cells, it enhanced the response of CT.4R to IL-4 and increased the level of thymidine incorporation up to more than 60-fold in a concentration-dependent manner. GSH affected the binding of IL-4 to cellular receptors. Scatchard plot analysis showed that GSH treatment did not change the dissociation constant significantly, however, it increased the receptor number from 1173 ± 126 to 2112 ± 492 molecules per cell. Internalization and degradation studies of IL-4 showed that the amount of IL-4 internalized and degraded in the GSH-treated cells was about twofold higher than those in the cells without GSH treatment. These results suggest that GSH regulates the binding, internalization, degradation and T-cell proliferative activity of IL-4; alteration of cellular GSH levels may thus affect the growth and replication of cytotoxic T cells through growth stimulating cytokines such as IL-2 and IL-4. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - INTERLEUKIN-4
KW - INTERLEUKIN-2
KW - THYMIDINE
KW - CYTOKINES
KW - T cells
N1 - Accession Number: 13395946; Liang, S.-M. 1; Lee, N. 1; Finbloom, D.S. 1; Liang, C.-M. 2; Source Information: Mar1992, Vol. 75 Issue 3, p435; Subject: GLUTATHIONE; Subject: INTERLEUKIN-4; Subject: INTERLEUKIN-2; Subject: THYMIDINE; Subject: CYTOKINES; Subject: T cells; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Manohar, V.
AU - Brown, E.M.
AU - Chused, T.M.
T1 - Murine splenic null cell compartment contains distinct haemopoietic subpopulations: enlargement of a myeloid and an indifferentiated subset with the development of splenomegaly in New Zealand black mice.
JO - Immunology
JF - Immunology
Y1 - 1992/03//
VL - 75
IS - 3
M3 - Article
SP - 448
EP - 455
SN - 00192805
AB - We have previously reported that non-T, non-B 'null' cells increase with age in New Zealand Black (NZB) mice resulting in splenomegaly. Using a panel of monoclonal antibodies recognizing lineage-specific cell surface antigens we demonstrate four distinct subsets within this null cell compartment: (1) undifferentiated: (2) T lineage with undetectable Thy-1.2; (3) myeloid/erythroid: and (4) a pre-B/ plasma cell type. All four subsets also occur in non-autoimmune mice. The frequency of these populations arc similar in the young mice of all the strains examined, although the total number of null cells is higher in NZB. The elevation of null cells in young NZB mice is controlled by a single dominant gene in the genetic cross with New Zealand White (NZW) mice and does not appear closely related to the subsequent development of autoimmune disease. The proportion of mycloid/erythroid null cells increases with age in NZB as splenomegaly develops. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - MONOCLONAL antibodies
KW - CELL surface antigens
KW - HEMATOPOIETIC system
KW - AUTOIMMUNE diseases
KW - PLASMA cells
N1 - Accession Number: 13395976; Manohar, V. 1; Brown, E.M. 2; Chused, T.M. 2; Source Information: Mar1992, Vol. 75 Issue 3, p448; Subject: CELLS; Subject: MONOCLONAL antibodies; Subject: CELL surface antigens; Subject: HEMATOPOIETIC system; Subject: AUTOIMMUNE diseases; Subject: PLASMA cells; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1992-28660-001
AN - 1992-28660-001
AU - Nelson, Scott H.
AU - McCoy, George F.
AU - Stetter, Maria
AU - Vanderwagen, W. Craig
T1 - An overview of mental health services for American Indians and Alaska natives in the 1990s.
JF - Hospital & Community Psychiatry
JO - Hospital & Community Psychiatry
JA - Hosp Community Psychiatry
Y1 - 1992/03//
VL - 43
IS - 3
SP - 257
EP - 261
CY - US
PB - American Psychiatric Assn
SN - 0022-1597
N1 - Accession Number: 1992-28660-001. PMID: 1555821 Other Journal Title: Psychiatric Services. Partial author list: First Author & Affiliation: Nelson, Scott H.; US Public Health Service, Indian Health Service Mental Health Programs Branch, US. Release Date: 19920801. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Inuit; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 5. Issue Publication Date: Mar, 1992.
AB - Native Americans appear to be at higher risk than other US ethnic groups for mental health problems, including depression, substance abuse, domestic violence, and suicide. Initiatives to improve the quantity and quality of mental health services for Native Americans in the 1990s include development of a national mental health plan, increased technical assistance to Native American communities, additional training and research, and continued attention to standards that promote high-quality, culturally relevant care. Tribes themselves are seen as the most appropriate locus for the initiation of programs for preventing emotional problems in their communities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - improvement & quantity & quality of mental health services for Native Americans
KW - 1990s
KW - 1992
KW - American Indians
KW - Inuit
KW - Mental Health Services
KW - 1992
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
T1 - Propafenone Associated Agranulocytosis.
AU - Miwa, Linda J.
AU - Jolson, Heidi M.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1992/04//
VL - 15
IS - 4P1
SP - 387
EP - 390
SN - 01478389
N1 - Accession Number: 17476332; Author: Miwa, Linda J.: 1 Author: Jolson, Heidi M.: 1 ; Author Affiliation: 1 Epidemiology Branch, Division of Epidemiology and Surveillance, Office of Epidemiology and Biostatistics, Food and Drug Administration, Rockville, Maryland.; No. of Pages: 4; Language: English; Publication Type: Article; Update Code: 20050630
N2 - Propafenone hydrochloride was approved for marketing by the United States (U.S.) Food and Drug Administration (FDA) in November 1989. During V.S. clinical trials of propafenone, one case of agranulocytosis was seen. Seven additional cases have been reported outside the U.S. One German report of profound but reversible granulocytopenia appeared in 1982. In January 1991, the FDA reviewed adverse events reported with propafenone. Four reports of agranulocytosis were identified and are described. The reporting rate of approximately one case of agranulocytosis per 10,000 propafenone prescriptions per year likely underestimates the true incidence of this adverse event. ABSTRACT FROM AUTHOR
KW - PROPAFENONE
KW - UNITED States. Food & Drug Administration
KW - CLINICAL trials
KW - MEDICAL research
KW - AGRANULOCYTOSIS
KW - UNITED States
KW - adverse drug reaction
KW - agranulocytosis
KW - case-report
KW - postmirketing surveillance
KW - propafenone
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Driskell, William
AU - Ashley, David
AU - Grainger, James
AU - Sirimanne, Sarath
AU - Mazzola, Eugene
AU - Page, Sam
AU - Needham, Larry
AU - Hill, Robert
T1 - Identification of decomposition products of 1,1′-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1992/05//
VL - 48
IS - 5
M3 - Article
SP - 679
EP - 687
SN - 00074861
AB - The article presents a study which describes the incubation of 1,1'-Ethylidenebis [L-tryptophan] (EBT) on gastric fluids. The study uses various methods such as analyzing the incubation using liquid chromatography-mass spectrometry (LC-MS), and performing the nuclear magnetic resonance (NMR) spectroscopic analysis. Results show the transformation of EBT to L-tryptophan (LT) on the simulation of gastric conditions.
KW - RESEARCH
KW - Decomposition (Chemistry)
KW - Tryptophan
KW - Liquid chromatography-mass spectrometry
KW - Nuclear magnetic resonance spectroscopy
KW - Eosinophilia-myalgia syndrome
N1 - Accession Number: 70790209; Driskell, William 1; Ashley, David 1; Grainger, James 1; Sirimanne, Sarath 1; Mazzola, Eugene 2; Page, Sam 2; Needham, Larry 1; Hill, Robert 1; Affiliations: 1: Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 30333 Atlanta USA; 2: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 20204 Washington USA; Issue Info: May1992, Vol. 48 Issue 5, p679; Thesaurus Term: RESEARCH; Thesaurus Term: Decomposition (Chemistry); Subject Term: Tryptophan; Subject Term: Liquid chromatography-mass spectrometry; Subject Term: Nuclear magnetic resonance spectroscopy; Subject Term: Eosinophilia-myalgia syndrome; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/BF00195987
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jackson, Mary E.
AU - Burwell, Brian
AU - Clark, Robert F.
AU - Harahan, Mary
T1 - Eligibility for Publicly Financed Home Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/06//
VL - 82
IS - 6
M3 - Article
SP - 853
EP - 856
PB - American Public Health Association
SN - 00900036
AB - Objectives. Proposals for publicly financed home care for the elderly now tend to include cognitive impairment criteria as well as activities of daily living (ADL) criteria. The numbers of elderly deemed eligible for services will depend on the definitions of ADL and cognitive impairment used. Methods. Data from the 1984 National Long-Term Care Survey were used to generate a series of estimates of the community-dwelling elderly with ADL disabilities and cognitive impairment. Results. When only ADL criteria are used, estimates of disability range from 472 000 to over 3 million (1.6% to 12.5% of the community-dwelling elderly). These estimates increase to approximately 1 million to 4.2 million (3.5% to 14.0% of the community-dwelling elderly) when cognitive impairment criteria are added. Conclusions. The use of more stringent or more liberal eligibility criteria will have dramatic effects on the number of elders who qualify for services. The nature of the eligibility criteria employed in any expansion of federally financed home care benefits will be a major factor in determining the costs of such a program. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Home care services
KW - Congregate housing
KW - Mental illness
KW - Older people -- Care
KW - Mentally ill
N1 - Accession Number: 9207200299; Jackson, Mary E. 1; Burwell, Brian 1; Clark, Robert F. 2; Harahan, Mary 2; Affiliations: 1: SysteMetrics, Lexington, Mass.; 2: US Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation, Washington, DC; Issue Info: Jun92, Vol. 82 Issue 6, p853; Subject Term: Home care services; Subject Term: Congregate housing; Subject Term: Mental illness; Subject Term: Older people -- Care; Subject Term: Mentally ill; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 623312 Assisted Living Facilities for the Elderly; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Crane, Nancy T.
AU - Lewis, Christine J.
AU - Yetley, Elizabeth A.
T1 - Do Time Trends in Food Supply Levels of Macronutrients Reflect Survey Estimates of Macronutrient Intake.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/06//
VL - 82
IS - 6
M3 - Article
SP - 862
EP - 866
PB - American Public Health Association
SN - 00900036
AB - Background. Two types of data may be used to estimate trends in food and nutrient intake by the US population: per capita food supply estimates and survey estimates of individual intake. Because these data vary markedly in measurement goals and methods, we examined whether trends in food supply and survey intake estimates for fat, carbohydrate, and protein are reflective of one another. Methods. The data selected for comparison included all available survey estimates of mean intake by the US population (i.e., periodie estimates from 1965 to 1988) and all available per capita food supply estimates from a comparable time period (i.e., annual estimates from 1965 to 1985). Results. The two types of data generally did not reflect the same trends. Furthermore, expressing macronutrient levels as percentage of calories rather than in grams affected the trend relationships. Conclusions. Our findings indicate that caution is needed in the selection and application of available data to estimate trends in macronutrient intake by the US population and in the interpretation of these data with regard to public health research, policies, and programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food supply
KW - Population
KW - Carbohydrates
KW - Proteins
KW - Fat
N1 - Accession Number: 9207200302; Crane, Nancy T. 1; Lewis, Christine J. 1; Yetley, Elizabeth A. 1; Affiliations: 1: Food and Drug Administration, US Department of Health and Human Services, Washington, DC; Issue Info: Jun92, Vol. 82 Issue 6, p862; Thesaurus Term: Food supply; Thesaurus Term: Population; Subject Term: Carbohydrates; Subject Term: Proteins; Subject Term: Fat; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Wong, R. J.;
AU - Fahrner, R.;
AU - Minor, J.;
T1 - Accidental exposure to HIV infection: ten years of experience
CT - Accidental exposure to HIV infection: ten years of experience
JO - ASHP Annual Meeting
JF - ASHP Annual Meeting
Y1 - 1992/06/01/
VL - 49
IS - Jun
SP - PI
EP - 56
AD - UCLA Medical Center, 10833 Le Conte Ave, Los Angeles, CA, USA; SF General Hospital, 995 Potrero Avenue, San Francisco, CA, USA; U.S. Public Health Service, NIH, Building 10, Rm IN-257, Bethesda, MD, USA
N1 - Accession Number: 29-07080; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Environmental Toxicity; Institutional Pharmacy Practice
N2 - This program will cover the incidence of accidental exposure to HIV infection in the workplace and review hospital policy to minimize exposure, and to handle exposed workers in a confidential manner. The past ten years will be reviewed, covering the incidence of exposure and the number of documented cases, and identifying activities which place the worker at increased risk of infection. Policies from two different institutions will be presented. Financial considerations, confidentiality and treatment options will also be presented. Cases will also be presented to illustrate procedures and spotlight controversies in handling patients and health care workers. The goal of this session is to review the incidence of accidental exposure to HIV infection and explore possible treatment options. Issues of workman's compensation, worker confidentiality and voluntary removal from direct patient care activities will be discussed. Several institutions have instituted services within the Infectious Diseases' Division in order to provide a mechanism for counseling, tracking and monitoring cases.
KW - ASHP meeting abstracts--HIV infection exposure, hospital personnel;
KW - Personnel--hospitals--HIV infection exposure;
KW - HIV infections--toxicity, environmental--hospital personnel;
KW - Toxicity, environmental--HIV infections--exposure, hospital personnel;
KW - Hospitals--personnel--HIV infection exposure, policies;
KW - Administration--policies and procedures--hospital personnel, HIV infection exposure;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Ignesti, Giovanni
AU - Lodovici, Maura
AU - Dolara, Piero
AU - Lucia, Pagliai
AU - Grechi, Daniele
T1 - Polycyclic aromatic hydrocarbons in olive fruits as a measure of air pollution in the valley of Florence (Italy).
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1992/06//
VL - 48
IS - 6
M3 - Article
SP - 809
EP - 814
SN - 00074861
AB - The article presents a research paper which investigates the use of polycylic aromatic hydrocarbons (PAH) in olive fruits to measure or monitor air pollution in the Valley of Florence, Italy. The study submits the concentrated extract into a silica column pre-washed with 20 ml if chloroform and iso-octane. Results indicate that car exhaust is the major source of PAHs in the valley.
KW - Aromatic compounds
KW - RESEARCH
KW - Chloroform
KW - Olive
KW - Air pollution -- Italy
KW - Florence (Italy)
KW - Italy
N1 - Accession Number: 70790228; Ignesti, Giovanni 1; Lodovici, Maura 1; Dolara, Piero 1; Lucia, Pagliai 2; Grechi, Daniele 2; Affiliations: 1: Department of Pharmacology and Toxicology, Viale Morgagni 65 50134 Florence Italy; 2: Public Health Service, USL 10A Florence Italy; Issue Info: Jun1992, Vol. 48 Issue 6, p809; Thesaurus Term: Aromatic compounds; Thesaurus Term: RESEARCH; Thesaurus Term: Chloroform; Subject Term: Olive; Subject Term: Air pollution -- Italy; Subject: Florence (Italy); Subject: Italy; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/BF00201139
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - O'Neill, Robert T.
AU - Beninger, Paul
AU - Wykoff, Randolf
T1 - Comment.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1992/06//
VL - 87
IS - 418
M3 - Article
SP - 579
EP - 581
SN - 01621459
AB - Presents the author's views on the various issues facing the AIDS and its statistical methodologic implications for clinical trials. Role of early clinical trials for AIDS; Modeling strategies in extracting additional information from clinical trials; View that controlled clinical trial plays a crucial role both in developing evidence to support the approval of a new drug and in determining effective treatment strategies; Claim that statisticians are responding in a proactive manner to the challenges posed by AIDS, by playing a major role in design, analysis, and interpretation of clinical studies.
KW - RESEARCH
KW - STATISTICS
KW - AIDS (Disease)
KW - CLINICAL trials
KW - MEDICAL experimentation on humans
KW - CLINICAL medicine
KW - EXPERIMENTAL design
N1 - Accession Number: 9705253034; O'Neill, Robert T. 1; Beninger, Paul 2; Wykoff, Randolf 3; Affiliations: 1: Director, Division of Biometrics, FDA.; 2: Assistant Director, Medical Affairs, Division of Anti-Viral Drug Products, Center for Drug Evaluation and Research, FDA.; 3: Director, Office of AIDS Coordination, FDA.; Issue Info: Jun92, Vol. 87 Issue 418, p579; Thesaurus Term: RESEARCH; Thesaurus Term: STATISTICS; Subject Term: AIDS (Disease); Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: CLINICAL medicine; Subject Term: EXPERIMENTAL design; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2015
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Nair, Jaygopal
AU - Rouse, David A.
AU - Morris, Sheldon L.
T1 - Nucleotide sequence analysis and serologic characterization of the Mycobacterium intracellulare homologue of the Mycobacterium tuberculosis 19 kDa antigen.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1992/06//
VL - 6
IS - 11
M3 - Article
SP - 1431
EP - 1439
PB - Wiley-Blackwell
SN - 0950382X
AB - Disseminated Mycobacterium avium/Mycobacterium intracellulare complex (MAC) disease is a frequent complication in patients with the acquired immune deficiency syndrome (AIDS). In this report, we present the nucleotide sequence of the M. intracellulare MI22 gene. Computer sequence comparisons reveal that the MI22 gene, which encodes a serologically active protein, has 78% DNA sequence identity and 77% protein sequence identity with the seroreactive 19 kDa Mycobacterium tuberculosis lipoprotein antigen. Southern blot hybridizations Indicate that an MI22 gene probe binds similar-sized restriction fragments in M. tuberculosis and M. Intracellulare genomic DNA. In addition, immunoblot analyses demonstrate that MI22 is recognized by sere from tuberculosis patients. These data further support the existence of 19 kDa MAC and M. tuberculosis protein homologues. Phase partitioning experiments and the presence of a consensus lipid modification site in the deduced MI22 protein sequence strongly suggest that MI22 is also a lipoprotein. Comparative analyses of these mycobacterial antigenic homologues may provide the basis for the design of species-specific diagnostic reagents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Mycobacterium tuberculosis
KW - Nucleotide sequence
KW - Genes
KW - Nucleotides -- Analysis
N1 - Accession Number: 16527358; Nair, Jaygopal 1; Rouse, David A. 1; Morris, Sheldon L. 1; Affiliations: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA; Issue Info: Jun1992, Vol. 6 Issue 11, p1431; Thesaurus Term: Antigens; Subject Term: Mycobacterium tuberculosis; Subject Term: Nucleotide sequence; Subject Term: Genes; Subject Term: Nucleotides -- Analysis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 6 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1993-06919-001
AN - 1993-06919-001
AU - Fisher, Richard C.
T1 - Patient education and compliance: A pharmacist's perspective.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 1992/06//
VL - 19
IS - 3
SP - 261
EP - 271
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
N1 - Accession Number: 1993-06919-001. PMID: 1300624 Partial author list: First Author & Affiliation: Fisher, Richard C.; US Public Health Service, US. Release Date: 19930201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Education; Pharmacists; Treatment Compliance. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Page Count: 11. Issue Publication Date: Jun, 1992.
AB - Of the 5 compliance theories identified in the literature, the communication model describes the best mechanism for pharmacists to educate their patients. During consultation sessions, essential knowledge and skills can be communicated to the patient that will maximize compliance. Monitoring medication refills is the most accessible method for pharmacists to identify noncompliant behavior. Determining patient noncompliance and making adjustments with patient education tactics will enable pharmacists to expand their professional role while improving patient outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient education techniques & assessed treatment compliance
KW - pharmacists
KW - 1992
KW - Client Education
KW - Pharmacists
KW - Treatment Compliance
KW - 1992
DO - 10.1016/0738-3991(92)90145-9
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Attfield, Michael D.
AU - Castellan, Robert M.
T1 - Epidemiological Data on US Coal Miners' Pneumoconiosis, 1960 to 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 964
EP - 970
PB - American Public Health Association
SN - 00900036
AB - Objectives. Statistics on prevalence of pneumoconiosis among working underground coal miners based on epidemiological data collected between 1960 and 1988 are presented. The main intent was to examine the time-related trend in prevalence, particularly after 1969, when substantially lower dust levels were mandated by federal act. Methods. Data from studies undertaken between 1960 and 1968 were collected and compared. Information for the period 1969 to 1988 was extracted from a large ongoing national epidemiological study. Tenure-specific prevalence rates and summary statistics derived from the latter data for four consecutive time intervals within the 19-year period were calculated and compared. Results. The results indicate a reduction in pneumoconiosis over time. The trend is similar to that seen in a large radiological surveillance program of underground miners operated concurrently. Conclusions. Although such factors as X-ray reader variation, changes in x-ray standards, and worker self-selection for examination may have influenced the findings to some extent, adjusted summary rates reveal a reduction in prevalence concurrent with reductions in coal mine dust levels mandated by federal act in 1969. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - DISEASES
KW - Epidemiology
KW - Public health
KW - Lungs -- Dust diseases
KW - Coal miners
N1 - Accession Number: 9208170775; Attfield, Michael D. 1; Castellan, Robert M. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV; Issue Info: Jul1992, Vol. 82 Issue 7, p964; Thesaurus Term: Occupational diseases; Thesaurus Term: DISEASES; Thesaurus Term: Epidemiology; Thesaurus Term: Public health; Subject Term: Lungs -- Dust diseases; Subject Term: Coal miners; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Attfield, Michael D.
T1 - British Data on Coal Miners' Pneumoconiosis and Relevance to US Conditions.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 978
EP - 983
PB - American Public Health Association
SN - 00900036
AB - Objectives. The current primary federal dust standard for US underground coal miners of 2 mg/m³ respirable dust is based on British epidemiological information on exposure-response derived in 1969. Since then, much new information has become available. This paper reviews and compares the available information as it relates to the US mining situation. methods. Recent exposure-response information on pneumoconiosis and dust exposure derived by British researchers was employed to estimate working-life risks of pneumoconiosis for miners exposed to 2 mg/m³. Results. It is estimated that close to 9% of underground coal miners who work for 40 years in a 2 mg/m³ environment would develop pneumoconiosis (category 1 or greater). Progressive massive fibrosis would develop in 0.7%. Conclusions. There are unresolved questions relating to the validity of extrapolating findings on British mines and miners to the US and also in predicting disease levels at the low end of the dust exposure spectrum. Given the data available, current information suggests miners who are employed for a working life-time at the current federal dust limit of 2 mg/m³ are still at risk of developing pneumoconiosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Epidemiology
KW - Lungs -- Dust diseases
KW - Coal miners
KW - United States
N1 - Accession Number: 9208170777; Attfield, Michael D. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV; Issue Info: Jul1992, Vol. 82 Issue 7, p978; Thesaurus Term: Occupational diseases; Thesaurus Term: Epidemiology; Subject Term: Lungs -- Dust diseases; Subject Term: Coal miners; Subject: United States; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Siska, Michael
AU - Jason, Janine
AU - Murdoch, Paul
AU - Wen Shan Yang
AU - Donovan, Robert J.
T1 - Recall of AIDS Public Service Announcements and Their Impact on the Ranking of AIDS as a National Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 1029
EP - 1032
PB - American Public Health Association
SN - 00900036
AB - The efficacy of two public service announcements from Phase V of the "America Responds to AIDS" (ARTA) campaign was assessed at two sites. Participants were randomly assigned to view a local news program, one with an ARTA public service announcement appearing six times and the other with no AIDS public service announcements. During telephone interviews with 907 participants 1 to 3 nights after viewing, 21% at Site A and 59% at Site B could correctly recall the ARTA public service announcements. Absolute mentions of AIDS as an important national issue increased. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - Public service advertising
KW - Local news television programs
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 9208170788; Siska, Michael 1; Jason, Janine 1; Murdoch, Paul 2; Wen Shan Yang 1; Donovan, Robert J. 1; Affiliations: 1: Applied Communications Research and Evaluation, National AIDS Information and Education Program, Centers for Disease Control, Department of Health and Human Services, Public Health Service, Atlanta, Ga.; 2: Ogilvy & Mather Advertising, Atlanta.; Issue Info: Jul1992, Vol. 82 Issue 7, p1029; Thesaurus Term: AIDS (Disease); Subject Term: Public service advertising; Subject Term: Local news television programs; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1993-03737-001
AN - 1993-03737-001
AU - Dick, Robert B.
T1 - Acute exposure research with organic solvents: The NIOSH experience.
T3 - Behavioural effects of contaminated air: Applying psychology in neurotoxicology
JF - Applied Psychology: An International Review
JO - Applied Psychology: An International Review
JA - Appl Psychol
Y1 - 1992/07//
VL - 41
IS - 3
SP - 219
EP - 228
CY - United Kingdom
PB - Blackwell Publishing
SN - 0269-994X
SN - 1464-0597
N1 - Accession Number: 1993-03737-001. Other Journal Title: International Review of Applied Psychology. Partial author list: First Author & Affiliation: Dick, Robert B.; National Inst for Occupational Safety & Health, Ctrs for Disease Control Public Health Service, Cincinnati, OH, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19930101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Occupational Exposure; Solvents. Minor Descriptor: Personnel. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Page Count: 10. Issue Publication Date: Jul, 1992.
AB - Research on the acute effects of solvent exposures in humans is supported by the National Institute for Occupational Safety and Health (NIOSH). Extramural and intramural laboratory and field research has been undertaken as well as efforts to disseminate resultant information through conference and workshop proceedings, current intelligence bulletins, criteria documents, industry-wide study reports, and journal publications of research experiments. NIOSH intramural research has concentrated on the subclinical neurobehavioral effects that may occur in workers in response to workplace exposures. The experiments have studied solvent combinations and solvents combined with drugs, caffeine, and alcohol. (French abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - research on acute effects of workplace organic solvent exposure
KW - workers
KW - 1992
KW - Experimentation
KW - Occupational Exposure
KW - Solvents
KW - Personnel
KW - 1992
DO - 10.1111/j.1464-0597.1992.tb00700.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-03737-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Alston, P G
AU - Stoss, F W
T1 - Environmental online: the greening of databases, Part 3: business and regulatory information
JO - Database Magazine
JF - Database Magazine
Y1 - 1992/08//
VL - 15
IS - 4
M3 - Article
SP - 17
EP - 35
SN - 01624105
AB - This paper reviews environmental information to be found on business databases. The business aspects of the environment are studied in terms of marketing, investing, and real estate. Public opinion on environmental issues as available on databases is also assessed. Both legislative and administrative regulations regarding the environment are also reviewed, in terms of availability on databases. A list of selected environment bulletin boards is provided. AUDIT MASTER, which provides coverage of regulatory requirements, is among the database systems reviewed.
KW - BUSINESS
KW - DATABASES
KW - ECOLOGY
KW - Environmental information
N1 - Accession Number: ISTA2703023; Alston, P G 1; Stoss, F W; Affiliations: 1 : US Department of Health and Human Services, Washington, DC; Source Info: Aug 1992, Vol. 15 Issue 4, p17; Note: Update Code: 2700; Subject Term: BUSINESS; Subject Term: DATABASES; Subject Term: ECOLOGY; Author-Supplied Keyword: Environmental information; Number of Pages: 19p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA2703023&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 107271434
T1 - Welcome and introduction... Fourth Annual Meeting of the Division of Organ Transplantation.
AU - Braslow JB
AU - Bowen GS
Y1 - 1992/08//1992 Aug
N1 - Accession Number: 107271434. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Congresses and Conferences
KW - Organ Transplantation
SP - 57
EP - 59
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 2
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Division of Organ Transplantation, Health Resources and Services Administration, 5600 Fishers Lane, Room 11A22, Rockville, MD 20857
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271434&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271436
T1 - Federal initiatives: priorities for 1992... Fourth Annual Meeting of the Division of Organ Transplantation.
AU - Braslow JB
Y1 - 1992/08//1992 Aug
N1 - Accession Number: 107271436. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Government Programs
KW - Financing, Government
KW - Organ Transplantation
KW - United States
SP - 60
EP - 62
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 2
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Division of Organ Transplantation, Health Resources and Services Administration, 5600 Fishers Lane, Room 11A22, Rockville, MD 20857
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271436&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271442
T1 - Report on the Surgeon General's Workshop on Increasing Organ Donation... Fourth Annual Meeting of the Division of Organ Transplantation.
AU - Novello AC
Y1 - 1992/08//1992 Aug
N1 - Accession Number: 107271442. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Organ Procurement -- United States
KW - Seminars and Workshops
KW - United States
SP - 63
EP - 66
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 2
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - U.S. Public Health Service, 200 Independent Avenue SW, Room 710G, Washington, DC 20201
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271442&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271464
T1 - Donor/recipient HIV testing: balancing medical practice with public health... Fourth Annual Meeting of the Division of Organ Transplantation.
AU - Bowen GS
Y1 - 1992/08//1992 Aug
N1 - Accession Number: 107271464. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - HIV Infections -- Prevention and Control
KW - Transplant Recipients
KW - United States Public Health Service
KW - United States
KW - Centers for Disease Control and Prevention (U.S.)
KW - Practice Guidelines
KW - Government Regulations
SP - 93
EP - 94
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 2
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
AB - As a result of a recent incident involving the transmission of the HIV infection from a seronegative donor, there has been considerable concern about the issue of public safety in the organ procurement and transplant system. In response to this incident, the Public Health Service (PHS) convened an intra-agency workgroup to evaluate the need for regulation and new procedures regarding organ transplantation, specifically as it relates to the screening and testing of organ donors and recipients for blood-borne pathogens. After the workgroup met on a number of occasions, a strong recommendation was made by the workgroup to the Assistant Secretary for Health (ASH) to institute recipient testing and look back procedures. Upon acceptance of the workgroup recommendations by the ASH, an interim request was issued by HRSA for transplant centers to test recipients at 3, 6 and 12 month intervals post-transplant. Anyone found to have HIV infection at any of the three intervals or who died at anytime with an HIV related illness or pathologic findings of HIV in who had not been infected at the time of transplant was to be reported to UNOS, the OPO and the State Health Department so 'lookback' procedures could be instituted. Following this decision, a consensus was reached among the Health Resources and Services Administration, the Centers for Disease Control (CDC), the Food and Drug Administration and the transplant community that post-transplant testing one time at 6 months would be sufficient for adequate infection control. Ultimately, the PHS will request that the transplant community follow the guidelines for HIV testing that will be put forth by the CDC in a future issue of Morbidity and Mortality Weekly Report.
SN - 0905-9199
AD - Bureau of Health Resources Development, Health Resources and Services Administration, 5600 Fishers Lane, Room 1111, Rockville, MD 20857
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271464&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1993-02940-001
AN - 1993-02940-001
AU - West, Margaret A.
AU - Richardson, Mary
AU - LeConte, Judith
AU - Crimi, Carol
AU - Stuart, S.
T1 - Identification of developmental disabilities and health problems among individuals under child protective services.
JF - Mental Retardation
JO - Mental Retardation
JA - Ment Retard
Y1 - 1992/08//
VL - 30
IS - 4
SP - 221
EP - 225
CY - US
PB - American Assn on Mental Retardation
SN - 0047-6765
N1 - Accession Number: 1993-02940-001. PMID: 1518402 Other Journal Title: Intellectual and Developmental Disabilities. Partial author list: First Author & Affiliation: West, Margaret A.; US Dept of Health & Human Service, Public Health Service, Seattle, WA, US. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19930101. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Developmental Disabilities; Disorders; Screening; Social Services. Classification: Community & Social Services (3373). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Empirical Study. Page Count: 5. Issue Publication Date: Aug, 1992.
AB - Case records of 150 children identified to Child Protective Services (CPSs) were reviewed to determine the availability of health and developmental information. A screening protocol was developed that CPS workers could use to identify children, siblings, and parents who might need further evaluation and/or specialized services. Of the 150 records examined, 17 children (11%) were identified as having a developmental disability, and an additional 35 (23%) were suspected of having a developmental disability. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - availability of health related information & screening for developmental disabilities & health problems
KW - 0–17 yr olds referred to child protective services
KW - 1992
KW - Developmental Disabilities
KW - Disorders
KW - Screening
KW - Social Services
KW - 1992
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-02940-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1993-05982-001
AN - 1993-05982-001
AU - DeBruyn, Lemyra M.
AU - Lujan, Carol C.
AU - May, Philip A.
T1 - A comparative study of abused and neglected American Indian children in the Southwest.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 1992/08//
VL - 35
IS - 3
SP - 305
EP - 315
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
N1 - Accession Number: 1993-05982-001. PMID: 1519083 Partial author list: First Author & Affiliation: DeBruyn, Lemyra M.; Indian Health Service Office of Mental Health Programs, Albuquerque, NM, US. Release Date: 19930201. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; American Indians; Child Abuse; Child Neglect; Family Background. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 11. Issue Publication Date: Aug, 1992.
AB - Compared descriptive, qualitative, and quantitative data from a clinically identified sample of abused and neglected Indian children with a matched sample of controls. Ss were 53 families with a total of 117 target children (aged 1–21 yrs) and 51 families with 137 matched children. Alcohol abuse was present in virtually all families that abused or neglected their children; however, alcohol abuse existed exclusive of the association with child abuse/neglect. Results demonstrate that alcohol abuse is a necessary, but not sufficient, condition for child abuse/neglect. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - descriptive & qualitative & quantitative data on familial alcohol abuse & other risk factors
KW - abused or neglected American Indian 1–21 yr olds
KW - 1992
KW - Alcohol Abuse
KW - American Indians
KW - Child Abuse
KW - Child Neglect
KW - Family Background
KW - 1992
DO - 10.1016/0277-9536(92)90027-N
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-05982-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Williamson, David F.
AU - Serdula, Mary K.
AU - Anda, Robert F.
AU - Levy, Alan
AU - Byers, Tim
T1 - Weight Loss Attempts in Adults: Goals, Duration, and Rate of Weight Loss.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/09//
VL - 82
IS - 9
M3 - Article
SP - 1251
EP - 1251
PB - American Public Health Association
SN - 00900036
AB - Objectives: Although attempted weight loss is common, little is known about the goals and durations of weight loss attempts and the rates of achieved weight loss in the general population. Methods. Data were collected by telephone in 1989 from adults aged 18 years and older in 39 states and the District of Columbia. Analyses were carried out separately for the 6758 men and 14,915 women who reported currently trying to lose weight. Results. Approximately 25% of the men respondents and 40% of the women respondents reported that they were currently trying to lose weight. Among men, a higher percentage of Hispanics (31%) than of Whites (25%) or Blacks (23%) reported trying to lose weight. Among women, however, there were no ethnic differences in prevalence. The average man wanted to lose 30 pounds and to weigh 178 pounds; the average woman wanted to lose 31 pounds and to weigh 133 pounds. Black women wanted to lose an average of 8 pounds more than did White women, but Black women's goal weight was 10 pounds heavier. The average rate of achieved weight loss was 1.4 pounds per week for men and 1.1 pounds per week for women; these averages, however, may reflect only the experience of those most successful at losing weight. Conclusions. Attempted weight loss is a common behavior, regardless of age, gender, or ethnicity, and weight loss goals are substantial; however, obesity remains a major public health problem in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Weight loss
KW - Reducing diets
KW - Obesity
KW - Washington (D.C.)
N1 - Accession Number: 9212212221; Williamson, David F. 1; Serdula, Mary K. 1; Anda, Robert F. 1; Levy, Alan 2; Byers, Tim 1; Affiliations: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, Ga.; 2: Division of Consumer Studies, Food and Drug Administration, Washington, DC; Issue Info: Sep92, Vol. 82 Issue 9, p1251; Thesaurus Term: Public health; Subject Term: Weight loss; Subject Term: Reducing diets; Subject Term: Obesity; Subject: Washington (D.C.); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Tabak, Ellen R.
AU - Olins, Nancy J.
T1 - A Segmentation Analysis of Prescription Drug Information-Seeking Motives Among the Elderly.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1992///Fall92
VL - 11
IS - 2
M3 - Article
SP - 115
EP - 125
PB - American Marketing Association
SN - 07439156
AB - A study was done to determine why elderly users of hypertension medication seek or avoid prescription drug information. Subjects were users of the American Association of Retired Persons Pharmacy Service who returned a questionnaire that measured theoretically relevant motivations and corresponding knowledge and behaviors. Analysis indicated four distinct segments of information seekers: the ambivalent learners, who viewed themselves as vulnerable to negative health information, not particularly healthy, but receptive to drug information; the uncertain patients, who perceived difficulty adhering to the regimen and reported low levels of information receipt from health professionals; the risk avoiders, who viewed information-seeking as a risk-control coping strategy; and the assertively self- reliant, who were the least receptive to information about their medication. The authors postulate different message strategies that could be targeted to these four segments in response to their informational needs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacy colleges
KW - Medicine -- United States
KW - Hypertension
KW - Drugs
KW - Associations, institutions, etc.
KW - United States
N1 - Accession Number: 9602154303; Morris, Louis A. 1; Tabak, Ellen R. 2; Olins, Nancy J. 3; Affiliations: 1: Branch Chief, Marketing Practices and Communications.; 2: Social Science Analyst, Division of Drug Marketing, Advertising, and Communications, Food and Drug Administration.; 3: Director of Program Development, American Association of Retired Persons Pharmacy Service.; Issue Info: Fall92, Vol. 11 Issue 2, p115; Subject Term: Pharmacy colleges; Subject Term: Medicine -- United States; Subject Term: Hypertension; Subject Term: Drugs; Subject Term: Associations, institutions, etc.; Subject: United States; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 8225
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 1993-08073-001
AN - 1993-08073-001
AU - Zitzow, Darryl
T1 - Assessing student stress: School adjustment rating by self-report.
JF - School Counselor
JO - School Counselor
JA - Sch Couns
Y1 - 1992/09//
VL - 40
IS - 1
SP - 20
EP - 23
CY - US
PB - American School Counselor Association
SN - 0036-6536
N1 - Accession Number: 1993-08073-001. Partial author list: First Author & Affiliation: Zitzow, Darryl; Indian Health Service, Public Health Service White Earth Clinic, MN, US. Release Date: 19930301. Publication Type: Journal (0100), Peer-Reviewed Status-Unknown (0130). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Life Experiences; School Adjustment; Self-Report; Stress; Test Construction. Minor Descriptor: High School Students. Classification: Educational Measurement (2227); Classroom Dynamics & Student Adjustment & Attitudes (3560). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study. Page Count: 4. Issue Publication Date: Sep, 1992.
AB - Developed an instrument to measure the intensity of stress that high school students perceive in the areas of academic, social, personal, and family-home environments. 1,460 high school students completed the instrument on which they ranked 25 items per environment on a scale of 0–20. All 4 environments were represented in the top 20 most stressful events. Death of a brother or sister was the most stressful item, experienced by 7.9% of the Ss with a median stress response of 8.64. The 2nd most stressful event, death of a parent, occurred with slightly greater frequency (13.8%) and was ranked in intensity at 8.12. While comparisons of schools in urban and rural environments yielded no significant differences in perceived intensity of stress experiences, a greater percentage of Ss from schools in more urban environments reported experiencing selected social items. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - development & utility of self report instrument
KW - assessment of stressful life events
KW - high school students
KW - implications for school adjustment
KW - 1992
KW - Life Experiences
KW - School Adjustment
KW - Self-Report
KW - Stress
KW - Test Construction
KW - High School Students
KW - 1992
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-08073-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Glinsmann, Walter H.
T1 - Why is the Food and Drug Administration interested in dietary fatty acids and thrombosis?
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1992/10//
VL - 56
IS - 4
M3 - Article
SP - 785S
EP - 785S
SN - 00029165
AB - The article focuses on reasons behind the interest of the U.S. Food and Drug Administration in dietary fatty acids and thrombosis. Topics discussed include safety and efficacy of dietary fatty acids regarding their ability to modify hemostasis and thrombosis, regulation of message that are on food labels under the U.S. 1990 Nutrition Labeling and Education Act, and labeling of fatty acid-containing products.
KW - Food labeling
KW - Fatty acids in human nutrition
KW - Thrombosis
KW - Hemostasis
KW - Food law & legislation -- United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 94385872; Glinsmann, Walter H. 1; Affiliations: 1: Division of Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Oct1992, Vol. 56 Issue 4, p785S; Thesaurus Term: Food labeling; Subject Term: Fatty acids in human nutrition; Subject Term: Thrombosis; Subject Term: Hemostasis; Subject Term: Food law & legislation -- United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fredd, Stephen
T1 - Which surrogate endpoints are valid for assessing thrombotic tendency?
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1992/10//
VL - 56
IS - 4
M3 - Article
SP - 814S
EP - 814S
SN - 00029165
AB - The article reports that decreased hematocrit or platelet count is used as surrogate endpoint to identify thrombotic tendency in polycythemia patients. Topics discussed include requirement of hypercoagulability, vascular injury and stasis for clinically relevant thrombosis, occurrence of asymptomatic protein C deficiency at a high frequency in blood donors, and efficacy of long-term prophylactic oral anticoagulation therapy in preventing risk of bleeding.
KW - Platelet count
KW - Hematocrit
KW - Thrombosis -- Diagnosis
KW - Protein C deficiency
KW - Blood donors
KW - Anticoagulants (Medicine)
KW - Hemorrhage -- Prevention
N1 - Accession Number: 94385868; Fredd, Stephen 1; Affiliations: 1: Division of Gastrointestinal and Coagulation Drug Products, Food and Drug Administration, Rockville, MD; Issue Info: Oct1992, Vol. 56 Issue 4, p814S; Thesaurus Term: Platelet count; Subject Term: Hematocrit; Subject Term: Thrombosis -- Diagnosis; Subject Term: Protein C deficiency; Subject Term: Blood donors; Subject Term: Anticoagulants (Medicine); Subject Term: Hemorrhage -- Prevention; Number of Pages: 1p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=94385868&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Rinsler, S S
AU - Harter, J A
T1 - Predicting anaphylactoid reactions based on COSTART terms
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1992/10//Oct-Dec 1992
VL - 26
IS - 4
M3 - Article
SP - 505
EP - 518
SN - 00928615
AB - This paper discusses an epidemiological study designed to compare three nonsteroidal antiinflammatory drugs in terms of whether reaction was coded using the same COSTART terms. The analytical goal of the FDA review of COSTART data is to establish a method to determine the best algorithm for predicting amphylactoid reactions based on COSTART terms alone and to examine whether the best algorithm is drug specific. The algorithm presented is based on a stepwise logistic regression.
KW - TERMS & phrases
KW - Codes
KW - Drug information
KW - Pharmacy
N1 - Accession Number: ISTA2703974; Rinsler, S S 1; Harter, J A; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: Oct-Dec 1992, Vol. 26 Issue 4, p505; Note: Update Code: 2700; Subject Term: TERMS & phrases; Author-Supplied Keyword: Codes; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Pharmacy; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Garrison, David L.
AU - Conrad, Steve M.
AU - Eilers, Paul P.
AU - Waldron, Ellen M.
T1 - CONFIRMATION OF DOMOIC ACID PRODUCTION BY PSEUDONITZSCHIA AUSTRALIS (BACILLARIOPHYCEAE) CULTURES.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1992/10//
VL - 28
IS - 5
M3 - Article
SP - 604
EP - 607
PB - Wiley-Blackwell
SN - 00223646
AB - Single clone isolates of Pseudonitzschia australis Frenguelli(= Nitzschia pseudoseriata Hasle) isolated from a toxic bloom in Monterey Bay, California produced domoic acid in culture. Although long-term historical records do not indicate previous blooms of this species on the Pacific coast, this is probably because it has been often misidentified as Nitzchia seriata Hasle; previous evidence for toxicity is lacking. Hydrographic data suggest that areas such as Monterey Bay might be" hot spots" for domoic acid-producing blooms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Algal blooms
KW - Diatoms
KW - Hydrography
KW - Monterey Bay (Calif.)
KW - California
KW - United States
KW - Amnesic shellfish poisoning
KW - Bacillariophyceae
KW - domoic acid
KW - Nitzschia pseudoseriatsa
KW - Pseudonitzschia australis
KW - toxic blooms
N1 - Accession Number: 10780640; Garrison, David L. 1; Conrad, Steve M. 2; Eilers, Paul P. 2; Waldron, Ellen M. 2; Affiliations: 1: Institute of Marine Sciences, University of California, Santa Cruz, California 95064.; 2: U. S. Food and Drug Administration, Office of Seafood, HFF 520, 200 C. St. Southwest, Washington, D. C. 20204.; Issue Info: Oct92, Vol. 28 Issue 5, p604; Thesaurus Term: Algal blooms; Thesaurus Term: Diatoms; Thesaurus Term: Hydrography; Subject: Monterey Bay (Calif.); Subject: California; Subject: United States; Author-Supplied Keyword: Amnesic shellfish poisoning; Author-Supplied Keyword: Bacillariophyceae; Author-Supplied Keyword: domoic acid; Author-Supplied Keyword: Nitzschia pseudoseriatsa; Author-Supplied Keyword: Pseudonitzschia australis; Author-Supplied Keyword: toxic blooms; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1529-8817.ep10780640
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=10780640&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107002301
T1 - Medical center studies how consistently workers use gloves to prevent infection: nurses had the most consistent compliance rate with an overall figure of 91.4 percent.
AU - Wilkinson WE
Y1 - 1992/11//1992 Nov
N1 - Accession Number: 107002301. Language: English. Entry Date: 20010302. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Consumer Health; USA. NLM UID: 7610574.
KW - Cross Infection -- Prevention and Control
KW - Gloves
KW - Health Personnel
KW - Professional Compliance
KW - Academic Medical Centers
KW - Hospitals, Urban
KW - United States
SP - 35
EP - 40
JO - Occupational Health & Safety
JF - Occupational Health & Safety
JA - OCCUP HEALTH SAF
VL - 61
IS - 11
CY - Chatsworth, California
PB - 1105 Media, Inc.
SN - 0362-4064
AD - Arizona Court of Appeals and Commissioned Officer, U.S. Public Health Service Reserve, Tucson, Arizona
U2 - PMID: 1470430.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Selevan, Sherry
AU - Landrigan, Philip
T1 - The Mortality of Lead Smelter Workers: An Update.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/12//
VL - 82
IS - 12
M3 - Article
SP - 1641
EP - 1644
PB - American Public Health Association
SN - 00900036
AB - Objectives. Mortality studies of lead workers have shown excesses of nonmalignant renal disease and cerebrovascular disease. Animal studies and one human study have shown excess kidney cancer. We have updated a mortality study of male lead smelter workers (n = 1990). Methods. An analysis was conducted using standard life table techniques. The updated analysis added 11 years of follow-up and 363 new deaths. Results. The original study had found elevated but nonsignificant risks for kidney cancer, stroke, and nonmalignant renal disease, probably attributable to lead exposure. Deaths from accidents and nonmalignant respiratory disease were significantly elevated, but probably not as a result of lead exposure. In the updated study, no new deaths from nonmalignant renal disease occurred (9 observed, standardized mortality ratio = 1.21). Three more deaths from kidney cancer were observed, yielding a standardized mortality ratio of 1.93 (9 observed, 95% CI = 0.88, 3.67), which increased for those who had worked in areas with the highest lead exposure (8 observed, standardized mortality ratio = 2.39, 95% CI = 1.03, 4.71). Cerebrovascular disease remained elevated for those with more than 20 years of exposure (26 observed, standardized mortality ratio = 1.41, 95% CI = 0.92, 2.07). Conclusions. This cohort with high lead exposure showed a diminishing excess of death from nonmalignant renal disease, a continued excess from kidney cancer, and an excess of cerebrovascular disease only in those with longest exposure to lead. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mortality
KW - Lead smelting
KW - Employees
KW - Kidney diseases
KW - Cerebrovascular disease
KW - Kidneys -- Cancer
KW - Death
N1 - Accession Number: 9306166053; Steenland, Kyle 1; Selevan, Sherry 2; Landrigan, Philip 3; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Environmental Protection Agency, Washington, DC; 3: Mount Sinai School of Medicine, New York, NY; Issue Info: Dec1992, Vol. 82 Issue 12, p1641; Subject Term: Mortality; Subject Term: Lead smelting; Subject Term: Employees; Subject Term: Kidney diseases; Subject Term: Cerebrovascular disease; Subject Term: Kidneys -- Cancer; Subject Term: Death; NAICS/Industry Codes: 331410 Nonferrous Metal (except Aluminum) Smelting and Refining; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Bjornson, D. C.;
AU - Hiner, W. O.;
AU - Potyk, R. P.;
AU - Nelson, B. A.;
AU - Lombardo, F. A.;
AU - Morton, T. A.;
AU - Larson, L. V.;
AU - Martin, B. P.;
AU - Sikora, R. G.;
AU - Cammarata, F. A.;
T1 - Evaluation of the effect of clinical pharmacists on inpatient health care outcomes: final results
CT - Evaluation of the effect of clinical pharmacists on inpatient health care outcomes: final results
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1992/12/01/
VL - 27
IS - Dec
SP - PI
EP - 04
AD - Pharmacy Service, Walter Reed Army Medical Center, Washington, DC 20307, USA and Department of the Army, Office of the Surgeon General, 5109 Leesburg Pike, Falls Church, VA 22041, USA
N1 - Accession Number: 30-00712; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Sociology, Economics and Ethics
N2 - This study, funded through the ASHP Research and Education Foundation, evaluated the effect of clinical pharmacists on inpatient health care outcomes and determined their cost effectiveness. The study was a one-year experimental study comparing medicine and surgery patients followed by health care teams with and without clinical pharmacists. The independent variable of interest was the health care team with the dependent variables being length of stay (LOS), mortality, and drug cost per admission. Results (n=3081) showed a statistically significant difference in LOS (p=0.028) and drug cost per admission (p=0.048) but not in mortality (p=0.25). The average cost effectiveness of a clinical pharmacist was $372 per inpatient admission. We conclude that clinical pharmacists who are integral members of health care teams in the hospital inpatient setting can have a positive effect on health care outcomes and, in addition, are cost effective.
KW - ASHP meeting abstracts--clinical pharmacy, patient outcomes;
KW - Clinical pharmacy--services--patient outcomes;
KW - Pharmacy, institutional, hospital--services--clinical, patient outcomes;
KW - Administration--hospital pharmacy--clinical services, patient outcomes;
KW - Pharmacy services--hospitals--clinical, patient outcomes;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-00712&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Burke, L. B.;
AU - Jolson, H. M.;
AU - Goetsch, R. A.;
AU - Ahronheim, J. C.;
T1 - Spontaneous adverse drug event reporting in the elderly
CT - Spontaneous adverse drug event reporting in the elderly
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1992/12/01/
VL - 27
IS - Dec
SP - PI
EP - 27
AD - Epidemiology Branch, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Room 15B-18, Rockville, MD 20857, USA
N1 - Accession Number: 30-00946; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Adverse Drug Reactions; Information Processing and Literature
N2 - Current drug use and adverse drug event (ADE) reporting in the U.S. were reviewed to highlight differential patterns of drug use with advancing age and to identify potential drug safety concerns. Two national data bases were used in this review: the National Disease and Therapeutic Index (NDTI) and FDA's Spontaneous Reporting System (SRS). Aggregate age- and sex-specific rates of drug use and reported ADEs in 1990 were calculated using U.S. Census Bureau figures. These rates were further examined by drug class and ADE outcome. The age- and sex-specific reported ADE rates increased with each successive adult 10-year age group through the age of 65-74 in females and 75-84 in males. ADE reporting rates in young adults were higher among women than among men until age 55 when the reverse was true. The proportion of reports that were serious increased with age. In persons aged 65 years and over, 68% of the reported ADEs arose from drugs that represented 84% of use. The data suggest that there is increased risk of ADE with age; however, ADE surveillance using the SRS cannot estimate incidence rates since the magnitude of under-reporting is unknown.
KW - ASHP meeting abstracts--adverse reactions, geriatrics;
KW - Drugs, adverse reactions--reports--geriatrics;
KW - Geriatrics--drugs, adverse reactions--reports;
KW - Reports--drugs, adverse reactions--age effects;
KW - Drug utilization--evaluation--adverse reactions, geriatrics;
KW - Pharmacy, institutional, hospital--drug utilization--evaluation, adverse reactions, geriatrics;
KW - Rational therapy--drug utilization--evaluation, adverse reactions, geriatrics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 1993-28158-001
AN - 1993-28158-001
AU - Sanchez, Maria E.
AU - Morchio, Giovanna
T1 - Probing 'Don't Know' answers: Effects on survey estimates and variable relationships.
JF - Public Opinion Quarterly
JO - Public Opinion Quarterly
JA - Public Opin Q
Y1 - 1992///Win 1992
VL - 56
IS - 4
SP - 454
EP - 474
CY - United Kingdom
PB - Oxford University Press
SN - 0033-362X
SN - 1537-5331
N1 - Accession Number: 1993-28158-001. Partial author list: First Author & Affiliation: Sanchez, Maria E.; US Public Health Service, Agency for Health Care Policy & Research, US. Release Date: 19930801. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Interviewing; Methodology; Surveys. Minor Descriptor: Telephone Systems. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 21. Issue Publication Date: Win 1992.
AB - Argued that unconditional probing of 'don't know' (DK) answers may not be a desirable practice, particularly regarding knowledge items. Response effects attributable to the behavior of 2 groups of interviewers who administered the same set of survey questions but probed DK answers at different rates were examined. One group telephoned 801 individuals, and the other interviewed 815 individuals in the field. Results indicate that the probing of DK answers encouraged guesswork on the part of uninformed respondents, giving rise to significant distributional differences and differences in means across half samples for the affected variables. However, relationships between variables were unaffected by probing effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - probing of 'don't know' answers in telephone vs field interviews
KW - survey results & variable relationships
KW - interviewers & interviewees
KW - 1992
KW - Interviewing
KW - Methodology
KW - Surveys
KW - Telephone Systems
KW - 1992
DO - 10.1086/269337
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-28158-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 104787485
T1 - An evaluation of freestanding alcoholism treatment for Medicare recipients.
AU - Lo, A
AU - Woodward, A
Y1 - 1993/01//
N1 - Accession Number: 104787485. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118.
KW - Alcoholism -- Rehabilitation
KW - Ambulatory Care Facilities -- Economics
KW - Medicare -- Economics
KW - Substance Use Rehabilitation Programs -- Economics
KW - Adult
KW - Aged
KW - Alcoholism -- Economics
KW - United States Centers for Medicare and Medicaid Services
KW - Cost Benefit Analysis
KW - Female
KW - Human
KW - Male
KW - Middle Age
KW - Outcomes (Health Care)
KW - United States
SP - 53
EP - 68
JO - Addiction
JF - Addiction
JA - ADDICTION
VL - 88
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The Health Care Financing Administration (HCFA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) conducted a demonstration between 1982 and 1985 to test the feasibility of providing payments for alcoholism treatment services to Medicare and Medicaid recipients in specially selected freestanding facilities. This study of the Medicare part of the demonstration answers two questions: do freestanding facilities save money for Medicare and do their patients have lower health care utilization following initiation of treatment than patients treated in hospital-based facilities? The statistical methodology is a logit and cluster approach. The analysis begins with a logistic regression model to predict the probability of patients seeking alcoholism treatment in either the demonstration (freestanding facility) or hospital-based cohort. The statistically significant variables from logit analysis are then used to form clusters. The health expenditures of freestanding and hospital patients are compared within homogeneous clusters. This study shows that the number of admissions, the average length of stay, and the average monthly health expenditures following the start of treatment are lower for the group treated in the freestanding facilities. The conclusion is that for some persons with alcohol problems, treatment in freestanding facilities is less costly and leads to lower subsequent health care utilization than treatment in hospitals.
SN - 0965-2140
AD - Substance Abuse and Mental Health Services Administration, US Public Health Service, Rockville, Maryland.
U2 - PMID: 8383557.
DO - 10.1111/j.1360-0443.1993.tb02763.x
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 1994-97000-025
AN - 1994-97000-025
AU - Wohlford, Paul
AU - Callan, Joanne E.
AU - Myers, Hector F.
ED - Wohlford, Paul
ED - Myers, Hector F.
ED - Callan, Joanne E.
ED - Wohlford, Paul, (Ed)
ED - Myers, Hector F., (Ed)
ED - Callan, Joanne E., (Ed)
T1 - Public–academic linkages.
T2 - Serving the seriously mentally ill: Public–academic linkages in services, research, and training.
Y1 - 1993///
SP - 3
EP - 15
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-216-3
N1 - Accession Number: 1994-97000-025. Partial author list: First Author & Affiliation: Wohlford, Paul; Center for Mental Health Services, Rockville, MD, US. Release Date: 19940701. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-216-3, Paperback. Language: English. Major Descriptor: Clinical Psychology Graduate Training; Emotional Disturbances; Mental Disorders; Mental Health Services; Public Health. Minor Descriptor: Aging; Minority Groups. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 13.
AB - This book has two main purposes: The first is to consolidate and facilitate the implementation of recommendations from recent training conferences that have focused on the underserved priority populations of seriously mentally ill adults, children and adolescents with serious emotional disturbances, and elderly and ethnic minorities with mental disorders. The second purpose is to suggest and promote ways of expanding the collaboration referred to as 'public-academic linkages for clinical training.' The chapters that follow contain a wealth of ideas as to how this can be done. In this chapter, we will first discuss the background of issues and conferences that led up to the 1990 National Conference on Implementing Public-Academic Linkages for Clinical Training in Psychology (Linkages Conference). Then we will describe the Linkages Conference itself. Finally, we present an overview of the chapters in this volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public-academic linkages
KW - clinical training
KW - mental illness
KW - emotional disturbaces
KW - ethnic minorities
KW - elderly
KW - 1993
KW - Clinical Psychology Graduate Training
KW - Emotional Disturbances
KW - Mental Disorders
KW - Mental Health Services
KW - Public Health
KW - Aging
KW - Minority Groups
KW - 1993
DO - 10.1037/10141-025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-97000-025&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
AU - Liu, Lillian
AD - US Department of Health and Human Services
A2 - U.S. Congress, Joint Economic Committee
T1 - Social Security in Transition in the Soviet Union (1985-1991) and in the Russian Federation (1992)
T2 - The former Soviet Union in transition. Volume 1. Study papers submitted to the Joint Economic Committee of the United States
PB - Joint Committee Print 103-11, Vol. 1
Y1 - 1993///
SP - 311
EP - 329
N1 - Accession Number: 0729290; Keywords: Social Security; Geographic Descriptors: Russian Federation; Geographic Region: Europe; Asia; Publication Type: Collective Volume Article; Update Code: 200405
KW - Social Security and Public Pensions H55
KW - Socialist Institutions and Their Transitions: Public Economics P35
KW - Socialist Institutions and Their Transitions: Consumer Economics; Health; Education and Training: Welfare, Income, Wealth, and Poverty P36
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 1993-41732-001
AN - 1993-41732-001
AU - Hanna, Eleanor Z.
AU - Faden, Vivian B.
AU - Harford, Thomas C.
T1 - Marriage: Does it protect young women from alcoholism?
JF - Journal of Substance Abuse
JO - Journal of Substance Abuse
JA - J Subst Abuse
Y1 - 1993///
VL - 5
IS - 1
SP - 1
EP - 14
CY - US
PB - Elsevier/JAI Press
SN - 0899-3289
N1 - Accession Number: 1993-41732-001. PMID: 8329877 Partial author list: First Author & Affiliation: Hanna, Eleanor Z.; NIH National Inst on Alcohol Abuse & Alcoholism, Public Health Service, Rockville, MD, US. Release Date: 19931101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Alcoholism; Human Females; Marital Status. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 14. Issue Publication Date: 1993.
AB - Studied the drinking practices of women (aged 24–32 yrs) who were respondents in the National Longitudinal Survey of Youth. Variations in drinking patterns for the years 1982–1988 as a function of changes in marital status were explored. Findings indicate that women who married or remarried decreased drinking, whereas those who became separated or divorced increased drinking. Women with alcoholic spouses experienced similar changes in drinking as did other women. The changes in drinking that accompanied changes in marital status may reflect a reaction to the disequilibrium created by instability and an accommodation to the new social position. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marital status
KW - drinking patterns
KW - alcoholism
KW - 24–32 yr old females
KW - 1993
KW - Alcohol Drinking Patterns
KW - Alcoholism
KW - Human Females
KW - Marital Status
KW - 1993
DO - 10.1016/0899-3289(93)90119-V
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-41732-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1993-31002-001
AN - 1993-31002-001
AU - Lo, Annie
AU - Woodward, Albert
T1 - An evaluation of freestanding alcoholism treatment for Medicare recipients.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 1993/01//
VL - 88
IS - 1
SP - 53
EP - 68
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
N1 - Accession Number: 1993-31002-001. PMID: 8383557 Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Lo, Annie; US Public Health Service, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19930801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Rehabilitation; Costs and Cost Analysis; Medicare; Treatment Facilities. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 16. Issue Publication Date: Jan, 1993.
AB - Tested the feasibility of providing payments for alcoholism treatment services to Medicare and Medicaid recipients in specially selected freestanding facilities. Using a logit and cluster approach, the study explored how freestanding facilities save money for Medicare and whether their patients have lower health care utilization following initiation of treatment than patients treated in hospital-based facilities. The number of admissions, the average length of stay, and the average monthly health expenditures following the start of treatment was lower for the group treated in the freestanding facilities. For some persons with alcohol problems, treatment in freestanding facilities is less costly and leads to lower subsequent health care utilization than treatment in hospitals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cost benefits of payment for hospital based vs freestanding alcoholism treatment
KW - Medicare recipients
KW - 1993
KW - Alcohol Rehabilitation
KW - Costs and Cost Analysis
KW - Medicare
KW - Treatment Facilities
KW - 1993
DO - 10.1111/j.1360-0443.1993.tb02763.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-31002-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Biagini, Raymond
AU - Henningsen, Gerry
AU - MacKenzie, Barbara
AU - Sanderson, Wayne
AU - Robertson, Shirley
AU - Baumgardner, Eric
T1 - Evaluation of acute immunotoxicity of alachlor in male F344/N Rats.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1993/02//
VL - 50
IS - 2
M3 - Article
SP - 266
EP - 273
SN - 00074861
AB - The article presents a study which aims to investigate the acute immunotoxicity of alachlor, a type of herbicides in the U.S., in male rats. The study analyzes a multiple immunoassay model and other chemicals such as reagent grade in two groups of laboratory animals. Results show that the laboratory animals had experienced no clinical signs, other rats seems listless after injection regimens.
KW - RESEARCH
KW - Alachlor
KW - Herbicides -- Toxicology
KW - Immunotoxicology
KW - Rats as laboratory animals
KW - Immunoassay -- Methodology
KW - United States
N1 - Accession Number: 70790424; Biagini, Raymond 1; Henningsen, Gerry 1; MacKenzie, Barbara 1; Sanderson, Wayne 2; Robertson, Shirley 1; Baumgardner, Eric 1; Affiliations: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Applied Biology Branch, Immunochemistry Research Section, 4676 Columbia Pkwy 45226 Cincinnati USA; 2: Division of Surveillance Hazards Evaluation and Field Studies, Industry Wide Studies Branch and Hazards Evaluation and Technical Assistance Branch, Cincinnati USA; Issue Info: Feb1993, Vol. 50 Issue 2, p266; Thesaurus Term: RESEARCH; Thesaurus Term: Alachlor; Thesaurus Term: Herbicides -- Toxicology; Subject Term: Immunotoxicology; Subject Term: Rats as laboratory animals; Subject Term: Immunoassay -- Methodology; Subject: United States; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF00191732
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=70790424&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1993-42969-001
AN - 1993-42969-001
AU - Wright, Curtis
AU - Moore, Richard D.
AU - Grodin, Douglas M.
AU - Spyker, Daniel A.
AU - Gill, Edward V.
T1 - Screening for disulfiram-induced liver test dysfunction in an inpatient alcoholism program.
JF - Alcoholism: Clinical and Experimental Research
JO - Alcoholism: Clinical and Experimental Research
JA - Alcohol Clin Exp Res
Y1 - 1993/02//
VL - 17
IS - 1
SP - 184
EP - 186
CY - United Kingdom
PB - Blackwell Publishing
SN - 0145-6008
SN - 1530-0277
N1 - Accession Number: 1993-42969-001. PMID: 8383924 Partial author list: First Author & Affiliation: Wright, Curtis; Food & Drug Administration US Public Health Service, Ctr for Drug Evaluation & Research, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19931101. Correction Date: 20130225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Rehabilitation; Disulfiram; Liver; Screening; Toxicity. Minor Descriptor: Alcoholism; Blood Serum; Drug Therapy. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 3. Issue Publication Date: Feb, 1993.
AB - Examined the frequency of disulfiram-related elevations of 4 hepatic screening chemistries using a retrospective record review design of 108 patients receiving disulfiram and 27 controls (mean age 33 yrs). The 4 screening serum chemistries performed were aspartate aminotransferase, alanine aminotransferase (SGPT), alkaline phosphatase, and γ-glutamyl transferase. 27 of the Ss who were taking 250 mg of disulfiram a day for 24 wks had disulfiram-related elevations in SGPT above the upper limit of normal, as opposed to 1 elevation in 27 controls. SGPT was the most specific and sensitive indicator of the 4 screening chemistries performed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sensitivity & specificity of screening serum chemistries
KW - detection of disulfiram induced liver test dysfunction
KW - alcoholic inpatients
KW - 1993
KW - Alcohol Rehabilitation
KW - Disulfiram
KW - Liver
KW - Screening
KW - Toxicity
KW - Alcoholism
KW - Blood Serum
KW - Drug Therapy
KW - 1993
DO - 10.1111/j.1530-0277.1993.tb00745.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-42969-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Johansson, A.
AU - Haraldson, T.
AU - Omar, R.
AU - Kiliaridis, S.
AU - Carlsson, G. E.
T1 - A system for assessing the severity and progression of occlusal tooth wear.
JO - Journal of Oral Rehabilitation
JF - Journal of Oral Rehabilitation
Y1 - 1993/03//
VL - 20
IS - 2
M3 - Article
SP - 125
EP - 131
SN - 0305182X
AB - This study represents an attempt to introduce a system for the longitudinal evaluation of the severity and the rate of progression of tooth wear. The material comprised a selected group of 10 males and 10 females, examined twice within an 18-month period. The subjects were predisposed to advanced occlusal wear and had a mean age of 32 years within the range of 16-56 years. Evaluation of occlusal wear was performed on a tooth-by-tooth basis, on study casts, using two ordinal scales, one for assessing the severity, and the other the progression of occlusal wear. The reliability of the scales was assessed by percentage inter-observer concordances. The sample exhibited higher occlusal wear scores in the incisor and canine regions compared to the posterior region. It was found that the overall progression in an 18-month follow-up period was slow. The inter-observer concordance in the evaluation of the severity of wear was 88%, and 91% in the progression of wear. Within the limitations of the described system, the scales may be utilized for determining the severity of occlusal wear and the rate of its deterioration in an individual's dentition. From a clinical standpoint, the need for future treatment may be based on such an evaluation of the progression of wear. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Rehabilitation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCLUSAL adjustment
KW - TEETH
KW - DENTITION (Tooth development)
KW - PEDIATRIC physiology
KW - CUSPIDS
KW - DENTAL care
N1 - Accession Number: 13454727; Johansson, A. 1,2; Haraldson, T. 3; Omar, R. 4; Kiliaridis, S. 5; Carlsson, G. E. 2; Source Information: Mar1993, Vol. 20 Issue 2, p125; Subject: OCCLUSAL adjustment; Subject: TEETH; Subject: DENTITION (Tooth development); Subject: PEDIATRIC physiology; Subject: CUSPIDS; Subject: DENTAL care; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1365-2842.ep13454727
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=13454727&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1993-33784-001
AN - 1993-33784-001
AU - O'Carroll, Patrick
T1 - Suicide causation: Pies, paths, and pointless polemics.
JF - Suicide and Life-Threatening Behavior
JO - Suicide and Life-Threatening Behavior
JA - Suicide Life Threat Behav
Y1 - 1993///Spr 1993
VL - 23
IS - 1
SP - 27
EP - 36
PB - Human Sciences Press, Inc.
SN - 0363-0234
SN - 1943-278X
N1 - Accession Number: 1993-33784-001. PMID: 8475530 Other Journal Title: Life-Threatening Behavior; Suicide. Partial author list: First Author & Affiliation: O'Carroll, Patrick; US Public Health Service, Ctrs for Disease Control & Prevention, Atlanta, GA, US. Other Publishers: Behavioral Publications; Guilford Publications; Wiley-Blackwell Publishing Ltd. Release Date: 19930901. Correction Date: 20130610. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: 25th Annual Meeting of the American Association of Suicidology (1992, Chicago, Illinois). Major Descriptor: Models; Suicide; Suicide Prevention. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Page Count: 10. Issue Publication Date: Spr 1993.
AB - Reviews several simple conceptual models of multiple causation (MC) of suicides as they relate to suicide prevention. It is suggested that a more explicit understanding of the nature of MC has the potential to obviate some of these misguided arguments and to facilitate cooperative prevention efforts among persons who choose to apply their energies at different points in the causal chain of suicide. To formulate a suicide prevention effort, public health importance of many nonpsychiatric causes of suicide should be identified and assessed. The efforts of those who choose to apply their energies at different points in the causal chain must be recognized and respected. Polymorphic prevention programs are preferable to pointless polemics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conceptual models of multiple causation of suicide & relation to prevention
KW - conference presentation
KW - 1993
KW - Models
KW - Suicide
KW - Suicide Prevention
KW - 1993
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1993-33784-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107393658
T1 - Instrumentation for spirometry.
AU - Hankinson JL
Y1 - 1993/04//1993 Apr-Jun
N1 - Accession Number: 107393658. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Spirometry -- Equipment and Supplies
KW - Diagnosis, Computer Assisted -- Equipment and Supplies
KW - Diagnosis, Computer Assisted -- Methods
KW - Diagnosis, Computer Assisted -- Standards
KW - Reference Values
KW - Reproducibility of Results
KW - Software
KW - Spirometry -- Classification
KW - Spirometry -- Standards
SP - 397
EP - 407
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 8
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - This review covers two broad areas related to instrumentation -- ATS standards and computer-assisted spirometry. The evolving spirometry standards are described including current ATS recommendations for equipment, quality control, maneuver performance, measurement procedures, test acceptability and reproducibility criterion. Advances in spirometry hardware and software center around the important issues associated with the increasing use of computerized systems for automating quality assessment and control.
SN - 0885-114X
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Room 256, Morgantown, WV 26505
U2 - PMID: 8506514.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107393658&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lindler, Luther E.
AU - Tall, Ben D.
T1 - Yersinia pestis pH 6 antigen forms fimbriae and is induced by intracellular association with macrophages.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1993/04/15/
VL - 8
IS - 2
M3 - Article
SP - 311
EP - 324
PB - Wiley-Blackwell
SN - 0950382X
AB - Ability to express pH 6 antigen (Ag) is necessary for full virulence of Yersinia pestis ; however, the function of the Ag in pathogenesis remains unclear. We determined the nucleotide sequence of a 4232 bp region of Y. pestis DNA which encoded the pH 6 Ag structural gene (psaA) and accessory loci necessary for Ag synthesis. Protein sequences encoded by the Y. pestis DNA were similar to accessory proteins which function in the biosynthesis of Escherichia coli fimbriae Pap, 1(88, K99 and C53 as well as the molecular chaperone for the Y. pestis capsule protein. Electron microscopy and immunogold labelling studies revealed that pH 6 Ag expressing E. coli or Yersinia produced flexible 'fibrillar' organelles composed of individual linear strands, multiple strand bundles or wiry aggregates of PsaA. Y. pestis associated with the murine macrophage-like cell line, RAW264.7, expressed pH 6 Ag in an intracellular acidification-dependent manner. Together with an earlier study showing that a Y. pestis psaA mutant was reduced in virulence, these results demonstrate that the expression of fimbriae which are Induced in host macrophages is involved in plague pathogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Escherichia coli
KW - Yersinia pestis
KW - Nucleotide sequence
KW - Proteins
N1 - Accession Number: 16435893; Lindler, Luther E. 1; Tall, Ben D. 2; Affiliations: 1: Division of Communicable Disease and Immunology, Department of Immunology, Walter Reed Army institute of Research, Washington, D.C. 20307-5100, USA; 2: Division of Microbiology, Food and Drug Administration, Washington, D.C. 20204, USA; Issue Info: Apr1993, Vol. 8 Issue 2, p311; Thesaurus Term: Antigens; Thesaurus Term: Escherichia coli; Subject Term: Yersinia pestis; Subject Term: Nucleotide sequence; Subject Term: Proteins; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 14p; Illustrations: 4 Black and White Photographs, 5 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zarkin, Gary A.
AU - Dean, Nancy
AU - Mauskopf, Josephine A.
AU - Williams, Richard
T1 - Potential Health Benefits of Nutrition Label Changes.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/05//
VL - 83
IS - 5
M3 - Article
SP - 717
EP - 724
PB - American Public Health Association
SN - 00900036
AB - OBJECTIVES. The Nutrition Labeling and Education Act of 1990 mandates the Food and Drug Administration to promulgate changes in nutrition labeling regulations. This study investigates the potential health benefits associated with expected changes in food consumption resulting from the act. METHODS. This paper provides four estimates of the potential health benefits from the dietary changes expected to occur as a result of the 1990 act. The upper bound estimates begin with the premise that all consumers will adopt the daily reference values of total fat, saturated fat, and cholesterol. The lower bound estimate is based on consumers' responses to a shelf-labeling program sponsored by the Food and Drug Administration in the 1980s. A computer model developed by Dr. Warren Browner and his associates was used to estimate the health benefits from reduced nutrient intakes. RESULTS. Estimates of the number of discounted life-years gained nationwide for the first 20 years after the implementation of the act range from a high of 1.2 million to a low of 40,000. CONCLUSIONS. The results of the study highlight that relatively small changes in nutrient intakes may generate large public health benefits. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food labeling
KW - Nutrition
KW - Food consumption
KW - Public health
KW - Labels -- Law & legislation
N1 - Accession Number: 9307095130; Zarkin, Gary A. 1; Dean, Nancy 1; Mauskopf, Josephine A. 2; Williams, Richard 3; Affiliations: 1: Center for Economics Research, Research Triangle Institute, Research Triangle Park, NC; 2: Burroughs Wellcome, Research Triangle Park, NC; 3: Food and Drug Administration, Washington, DC; Issue Info: May93, Vol. 83 Issue 5, p717; Thesaurus Term: Food labeling; Thesaurus Term: Nutrition; Thesaurus Term: Food consumption; Thesaurus Term: Public health; Subject Term: Labels -- Law & legislation; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Wysowski, Diane K.
AU - Baum, Carlene
T1 - Validity of Medicaid Diagnoses of Hip Fracture.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/05//
VL - 83
IS - 5
M3 - Letter
SP - 770
EP - 770
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to an article about the validity of Medicaid diagnoses of hip fracture.
KW - Letters to the editor
KW - Fractures
N1 - Accession Number: 9307095146; Wysowski, Diane K. 1; Baum, Carlene; Affiliations: 1: Division of Epidemiology and Surveillance, Food and Drug Administration, HFD-733, Rockville, MD 20857; Issue Info: May93, Vol. 83 Issue 5, p770; Subject Term: Letters to the editor; Subject Term: Fractures; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Marconi, Katherine M.
AU - Pruzan, Marcia
AU - Johnson, Annette M.
T1 - New York City's Metropolitan Area Breast Cancer Awareness Partnership.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/06//
VL - 83
IS - 6
M3 - Article
SP - 905
EP - 907
PB - American Public Health Association
SN - 00900036
AB - The article deals with the Metropolitan Area Breast Cancer Awareness Partnership program in New York City. The partnership consisted of many health organizations including the National Cancer Institute and the National Alliance of Breast Cancer Organizations. Initial assignments to program subcommittees include developing a packet of information materials to be distributed to all participants. The second Annual Breast Cancer Awareness Month Breakfast on October 22, 1991 was sponsored by the partnership.
KW - Breast cancer
KW - Cancer prevention
KW - Health education
KW - Associations, institutions, etc.
KW - Metropolitan areas
KW - New York (N.Y.)
KW - New York (State)
N1 - Accession Number: 9308046306; Marconi, Katherine M. 1; Pruzan, Marcia 2; Johnson, Annette M. 2; Affiliations: 1: Bureau of Health Resources Development, HRSA, Public Health Service, Room 1111, Rockville, MD 20857; 2: Bureau of Health Resources Development, HRSA., Public Health Service, Room 1111, Rockville, MD 20857.; Issue Info: Jun93, Vol. 83 Issue 6, p905; Subject Term: Breast cancer; Subject Term: Cancer prevention; Subject Term: Health education; Subject Term: Associations, institutions, etc.; Subject Term: Metropolitan areas; Subject: New York (N.Y.); Subject: New York (State); NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9308046306&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Waldman, Robert
T1 - Winning the Peace: The Strategic Implications of Military Civic Action.
JO - Armed Forces & Society (0095327X)
JF - Armed Forces & Society (0095327X)
J1 - Armed Forces & Society (0095327X)
PY - 1993///Summer93
Y1 - 1993///Summer93
VL - 19
IS - 4
M3 - Book Review
SP - 642
EP - 644
PB - Sage Publications Inc.
SN - 0095327X
AB - The article reviews the book "Winning the Peace: The Strategic Implications of Military Civic Action," edited by John W. De Pauw and George A. Luz.
KW - WINNING the Peace: The Strategic Implications of Military Civic Action (Book)
KW - DE Pauw, John W.
KW - LUZ, George A.
KW - MILITARY civic action
KW - NONFICTION
N1 - Accession Number: 9311240039; Source Information: Summer93, Vol. 19 Issue 4, p642; Subject Term: WINNING the Peace: The Strategic Implications of Military Civic Action (Book); Subject Term: DE Pauw, John W.; Subject Term: LUZ, George A.; Subject Term: MILITARY civic action; Subject Term: NONFICTION; Subject Term: ; Number of Pages: 3p; ; Document Type: Book Review; ; Full Text Word Count: 736;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=mth&AN=9311240039&site=ehost-live&scope=site
DP - EBSCOhost
DB - mth
ER -
TY - JOUR
TY - GEN
AU - Smith, E. B.,;
T1 - Integrating patient education in practice: effective counseling techniques
CT - Integrating patient education in practice: effective counseling techniques
JO - ASHP Annual Meeting
JF - ASHP Annual Meeting
Y1 - 1993/06/01/
VL - 50
IS - Jun
SP - PI
EP - 23
AD - Navajo Area Indian Health Service, P.O. Box G, Window Rock, AZ 86515, USA
N1 - Accession Number: 30-07189; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacy Practice
N2 - Patient consultation as practiced in the Indian Health Service (IHS) will be discussed. IHS pharmacists use an interactive patient consultation process that uses open-ended questions to involve the patient in the learning process. In addition to verification of the patient knowledge and attitude toward their disease and drug therapy, this process leads to identification of knowledge or attitude problems to be corrected by educational processes. In addition, the pharmacist by interacting with the patient is able to begin the process of determining patients' needs (physical and emotional) and meeting them. This process should begin a mutually beneficial exchange in which the patient grants authority to the provider and the provider gives competence and commitment (accepts responsibility) to the patient, i.e. pharmaceutical care. In the Navajo area, there are over 850,000 prescriptions dispensed annually and patient consultation is an integral part of that dispensing process. Due to the very heavy work load on these 12 facilities and 65 pharmacists, the pharmacists use this technique to prioritize patients for whom more intervention may be required. The review of the patient medical record and patient consultation become inter-related information gathering techniques for clinical decision making. The process is adaptable for use by inexperienced and very experienced clinicians. The implementation and evaluation of this process must become a part of the institutional mission and how IHS does this will be discussed. In addition, resources available to other groups will be discussed.
KW - ASHP meeting abstracts--patient consultation, pharmacists role;
KW - Patient information--consultation--pharmacists role, IHS;
KW - Pharmacists--role--patient consultation, IHS;
KW - Indian Health Service--patient information--consultation, pharmacists role;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-07189&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - McGinnis, T. J.;
T1 - National trends to improve patient medication education
CT - National trends to improve patient medication education
JO - ASHP Annual Meeting
JF - ASHP Annual Meeting
Y1 - 1993/06/01/
VL - 50
IS - Jun
SP - PI
EP - 25
AD - U.S. Food and Drug Administration, 5600 Fishers Lane, HFY-40, Rockville, MD 20857, USA
N1 - Accession Number: 30-07170; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics
N2 - The push for more and better patient information and education has been evident in recent years. A description of the Department of Health and Human Services Healthy People 2000 objectives pertaining to improving patient education and mechanisms to decrease medication misadventures through better information systems for health professionals will be provided. Organizations such as the National Council on Patient Information and Education, which is composed of 250 health, government, consumer and industry organizations, have taken many steps to improve medicine use through a variety of different mechanisms. Steps taken by the council to improve patient-professional communication on critical medicine issues will be discussed.
KW - ASHP meeting abstracts--patient education;
KW - Patient education--health care;
KW - Health care--education--health professions, future;
KW - National Council on Patient Information and Education--role--patient education;
KW - Healthy People 2000--patient education--National Council on Patient Information and Education;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=30-07170&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Krakauer, Henry
AU - Jacoby, Itzhak
AD - US Public Health Service and Uniformed Services U of Health Sciences
AD - Uniformed Services U of Health Sciences
T1 - Predicting the Course of Disease
JO - Inquiry
JF - Inquiry
Y1 - 1993///Summer
VL - 30
IS - 2
SP - 115
EP - 127
SN - 00469580
N1 - Accession Number: 0294518; Keywords: Disease; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199312
KW - Health Production I12
L3 - http://www.inquiryjournalonline.org/loi/inqr
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0294518&site=ehost-live&scope=site
UR - http://www.inquiryjournalonline.org/loi/inqr
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 2009-17057-001
AN - 2009-17057-001
AU - Marsh, Anna
T1 - Review of Psychoanalytic approaches to addiction.
T3 - Psychotherapy for the Addictions
JF - Psychotherapy: Theory, Research, Practice, Training
JO - Psychotherapy: Theory, Research, Practice, Training
JA - Psychotherapy (Chic)
Y1 - 1993///Sum 1993
VL - 30
IS - 2
SP - 369
EP - 369
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
SN - 1939-1536
N1 - Accession Number: 2009-17057-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research & Practice. Partial author list: First Author & Affiliation: Marsh, Anna; Center for Substance Abuse Treatment, U.S. Department of Health and Human Services, US. Other Publishers: Educational Publishing Foundation. Release Date: 20091012. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Addiction; Alcohol Abuse; Drug Abuse; Psychoanalysis. Minor Descriptor: Personality Traits. Classification: Psychoanalytic Therapy (3315). Population: Human (10). Reviewed Item: Smaldino, Angela (Ed). Psychoanalytic approaches to addiction=New York: Brunner/Mazel, 128 pp., $22.95. Current Issues in Psychoanalytic Practice, Monographs of the Society for Psychoanalytic Training, Number 3; 1991. Page Count: 1. Issue Publication Date: Sum 1993.
AB - Reviews the book, Psychoanalytic approaches to addiction edited by Angela Smaldino (see record [rid]1991-98128-000[/rid]). Contrary to what one might read into its title, the book is only partially about alcohol and other drugs AOD addiction. Three of its seven chapters address other types of addiction: destructive relationships, love, and food. The implication is that similarities among the various addictions will serve to illustrate a common unconscious motivation of 'the addictive personality' revealed by psychoanalysis. Nowhere in the book, however, is this explicitly stated. The chapters are as the beads of an unlinked chain. They are as a series of associations in a patient's stream of consciousness, each one rich in detail, captivating, and insightful, but as yet without the analyst's interpretation as to how they are linked. The daunting task of that interpretation is left to the reader. This book is a valiant effort to move the psychoanalytic field in the direction of accommodating to the needs of an important patient population. It is not a primer to be taken as a directive, but a useful tool that the more sophisticated reader may employ as an impetus to stimulate further thinking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychoanalytic approaches
KW - addiction
KW - alcohol & other drugs
KW - psychoanalysis
KW - 1993
KW - Addiction
KW - Alcohol Abuse
KW - Drug Abuse
KW - Psychoanalysis
KW - Personality Traits
KW - 1993
U2 - Smaldino, Angela (Ed). (1991); Psychoanalytic approaches to addiction; New York: Brunner/Mazel, 128 pp., $22.95. Current Issues in Psychoanalytic Practice, Monographs of the Society for Psychoanalytic Training, Number 3
DO - 10.1037/h0092290
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17057-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17053-001
AN - 2009-17053-001
AU - Diesenhaus, Herman I.
T1 - Review of Clean Start: An outpatient program for initiating cocaine recovery.
T3 - Psychotherapy for the Addictions
JF - Psychotherapy: Theory, Research, Practice, Training
JO - Psychotherapy: Theory, Research, Practice, Training
JA - Psychotherapy (Chic)
Y1 - 1993///Sum 1993
VL - 30
IS - 2
SP - 372
EP - 373
CY - US
PB - Division of Psychotherapy (29), American Psychological Association
SN - 0033-3204
SN - 1939-1536
N1 - Accession Number: 2009-17053-001. Other Journal Title: Psychotherapy; Psychotherapy: Theory, Research & Practice. Partial author list: First Author & Affiliation: Diesenhaus, Herman I.; Center for Substance Abuse Treatment, U.S. Department of Health and Human Services, US. Other Publishers: Educational Publishing Foundation. Release Date: 20091012. Correction Date: 20110117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Cocaine; Drug Rehabilitation; Outpatient Treatment. Minor Descriptor: Detoxification; Relapse Prevention. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Outpatient (60). Reviewed Item: McAuliffe, William E.; Albert, Jeffrey. Clean Start: An outpatient program for initiating cocaine recovery=New York: Guilford Press, 234 pp; 1992. Page Count: 2. Issue Publication Date: Sum 1993.
AB - Reviews the book, Clean Start: An outpatient program for initiating cocaine recovery by William E. McAuliffe and Jeffrey Albert (see record [rid]1992-98129-000[/rid]). McAuliffe and Albert have attempted to produce a manual that can be used by psychotherapists in a variety of practice sites to help cocaine dependent persons take the critical first steps in separating themselves from drug use (attaining abstinence through outpatient detoxification—the 'cessation phase') and to lay the foundation for long-term recovery through long-term treatment (using non-specified individualized treatment plans). Their goal is to provide the field with a fully articulated outpatient alternative to expensive inpatient hospital and residential settings for detoxification and initial relapse prevention training. The result is an easy-to-follow manual, combining a description of the theory of addiction and recovery underlying the approach—a blending of already blended social learning and behavioral operant conditioning models and their specific application involving education, skills training, counseling, and specified reinforcers. They provide a step-by-step protocol with scripts and handouts for each of the ten topic-centered sessions that make up the initial 4-week, 12-session cessation phase of the program. Less well developed is the individual counseling component of this phase that begins, in most cases, only after successful 'compliance' with the cessation treatment regimen and continues for an unspecified period of time. The mechanism for developing the long-term treatment plan for each client is comparatively undeveloped. Overall, as an initial effort to disseminate a treatment strategy based on clinical research, Clean Start must be praised. It is a valuable first step that can only be strengthened through due attention to the concerns expressed here. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Clean Start
KW - cocaine recovery
KW - drug rehabilitation
KW - outpatient treatment
KW - detoxification
KW - relapse prevention
KW - 1993
KW - Cocaine
KW - Drug Rehabilitation
KW - Outpatient Treatment
KW - Detoxification
KW - Relapse Prevention
KW - 1993
U2 - McAuliffe, William E.; Albert, Jeffrey. (1992); Clean Start: An outpatient program for initiating cocaine recovery; New York: Guilford Press, 234 pp
DO - 10.1037/h0092287
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17053-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Bright, Roselie A.
AU - Moore Jr., Roscoe M.
AU - Jeng, Lana L.
AU - Sharkness, Casherine M.
AU - Hamburger, Stanford E.
AU - Hamilton, Peggy M.
T1 - The Prevalence of Tympanostomy Tubes in Children in the United States, 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/07//
VL - 83
IS - 7
M3 - Article
SP - 1026
EP - 1028
PB - American Public Health Association
SN - 00900036
AB - Information from the 1988 National Health Interview Survey Medical Device Implant Supplement was used to obtain the first population estimates of the prevalence of implanted tympanostomy tubes, a common treatment for otitis media. The prevalence rate was estimated to be 13 per 1000 children aged younger than 18 years. Statistically significant differences in prevalence were found for sex (boys, 15/1000; girls, 10/1000), race (Whites, 15/1000; others, 4/1000), and activity level ("limited," 44/1000; others 11/1000). Thirty percent of the tubes were replacements; infection was the reason for 75% of the original implants. The morbidity and costs associated with tympanostomy tubes are of public health importance. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Public health
KW - DISEASES
KW - Otitis media
KW - Artificial implants
KW - Middle ear
KW - Biomedical materials
N1 - Accession Number: 9309075213; Bright, Roselie A. 1; Moore Jr., Roscoe M. 1; Jeng, Lana L. 1; Sharkness, Casherine M. 1; Hamburger, Stanford E. 1; Hamilton, Peggy M. 1; Affiliations: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md; Issue Info: Jul1993, Vol. 83 Issue 7, p1026; Thesaurus Term: Diseases; Thesaurus Term: Public health; Thesaurus Term: DISEASES; Subject Term: Otitis media; Subject Term: Artificial implants; Subject Term: Middle ear; Subject Term: Biomedical materials; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moore Jr., Roscoe M.
AU - Bright, Roselie A.
AU - Jeng, Lana L.
AU - Sharkness, Catherine M.
AU - Hamburger, Stanford E.
AU - Hamilton, Peggy M.
T1 - The Prevalence of Internal Orthopedic Fixation Devices in Children in the United States, 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/07//
VL - 83
IS - 7
M3 - Article
SP - 1028
EP - 1030
PB - American Public Health Association
SN - 00900036
AB - This study provides the first estimated prevalence of implanted orthopedic fixation devices (e.g., pins or wires) among children in the United States, based on the Medical Device Implant Supplement to the 1988 National Health Interview Survey. The overall prevalence was 27 per 10 000 children younger than 18 years; prevalence was highest (59/10 000) among those aged 12 to 17 years. The lower extremities were the most frequent body site (43%) and injury was the leading specific reason for implantation (37%). Some (10%) were replacement implants. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical equipment
KW - Artificial implants
KW - Biomedical engineering
KW - Biomedical materials
KW - Medical supplies
KW - Surgery
N1 - Accession Number: 9309075214; Moore Jr., Roscoe M. 1; Bright, Roselie A. 1; Jeng, Lana L. 1; Sharkness, Catherine M. 1; Hamburger, Stanford E. 1; Hamilton, Peggy M. 1; Affiliations: 1: Center fox Devices and Radiological Health, Food and Drug Administration, Rockville, Md; Issue Info: Jul1993, Vol. 83 Issue 7, p1028; Subject Term: Medical equipment; Subject Term: Artificial implants; Subject Term: Biomedical engineering; Subject Term: Biomedical materials; Subject Term: Medical supplies; Subject Term: Surgery; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 3p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gfroerer, Joseph C.
AU - Brodsky, Marc D.
T1 - Frequent Cocaine Users and Their Use of Treatment.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/08//
VL - 83
IS - 8
M3 - Article
SP - 1149
EP - 1149
PB - American Public Health Association
SN - 00900036
AB - Objectives. Despite decreases in the number of cocaine users since 1985, the consequences of cocaine use continue to rise. This paper provides descriptive data on frequent cocaine users that will help to explain these diverging trends and enable treatment planners to better predict the types of cocaine users who are likely to seek treatment. Methods. Data from the National Household Survey on Drug Abuse were used to study the characteristics of frequent cocaine users since 1985. The 1991 data were used to compare frequent users with infrequent users and nonusers. Results. Since 1985, frequent cocaine users have become older. In 1991, they were likely to be unemployed (32.4%), unmarried (82.3%), and without health insurance (39.4%). Most were cigarette smokers (86.8%) and marijuana users (88.4%), and 32.0% reported getting drunk weekly. Criminal behavior was more likely among frequent cocaine users than among infrequent users and nonusers. Almost a third (30.0%) reported drug abuse treatment experience in the past year. Conclusions. Despite the recent decreases in overall prevalence of cocaine use, the need for treatment of cocaine abusers will continue. Treatment must address multiple problems that occur in conjunction with cocaine abuse. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cocaine
KW - Narcotics
KW - Drug abuse -- Treatment
KW - Cocaine abuse
KW - Household surveys
KW - Therapeutics
N1 - Accession Number: 9312091182; Gfroerer, Joseph C. 1; Brodsky, Marc D.; Affiliations: 1: Substance Abuse and Mental Health Services Administration, Rockville, Md.; Issue Info: Aug1993, Vol. 83 Issue 8, p1149; Thesaurus Term: Cocaine; Thesaurus Term: Narcotics; Subject Term: Drug abuse -- Treatment; Subject Term: Cocaine abuse; Subject Term: Household surveys; Subject Term: Therapeutics; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107295013
T1 - Frequent cocaine users and their use of treatment.
AU - Gfroerer JC
AU - Brodsky MD
Y1 - 1993/08//
N1 - Accession Number: 107295013. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Substance Abusers
KW - Cocaine
KW - Substance Abuse -- Rehabilitation
KW - Surveys
KW - Interviews
KW - Health Status
KW - Crime
KW - Socioeconomic Factors
KW - Child
KW - Adolescence
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 1149
EP - 1154
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 83
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES. Despite decreases in the number of cocaine users since 1985, the consequences of cocaine use continue to rise. This paper provides descriptive data on frequent cocaine users that will help to explain these diverging trends and enable treatment planners to better predict the types of cocaine users who are likely to seek treatment. METHODS. Data from the National Household Survey on Drug Abuse were used to study the characteristics of frequent cocaine users since 1985. The 1991 data were used to compare frequent users with infrequent users and nonusers. RESULTS. Since 1985, frequent cocaine users have become older. In 1991, they were likely to be unemployed (32.4%), unmarried (82.3%), and without health insurance (39.4%). Most were cigarette smokers (86.8%) and marijuana users (88.4%), and 32.0% reported getting drunk weekly. Criminal behavior was more likely among frequent cocaine users than among infrequent users and nonusers. Almost a third (30.0%) reported drug abuse treatment experience in the past year. CONCLUSIONS. Despite the recent decreases in overall prevalence of cocaine use, the need for treatment of cocaine abusers will continue. Treatment must address multiple problems that occur in conjunction with cocaine abuse.
SN - 0090-0036
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Ln, Rockwall II Bldg, Suite 615, Rockville, MD 20857
U2 - PMID: 8342725.
DO - 10.2105/AJPH.83.8.1149
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kocsis, E.
AU - Trus, B. L.
AU - Steven, A. C.
AU - Smith, P. R.
AU - Hannah, J. H.
AU - Brennan, M. J.
AU - Kessel, M.
T1 - Orientation of porin channels in the outer membrane of Bordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1993/08//
VL - 9
IS - 3
M3 - Article
SP - 469
EP - 476
PB - Wiley-Blackwell
SN - 0950382X
AB - We have examined the surface topography and channel connectivity of a naturally crystalline porin that is known to be functional, and whose structure has not been perturbed by detergent extraction. A three-dimensional density map, calculated from two independent tilt series of negatively stained cell envelopes, reveals three separate channels per trimer on one side (the 'smooth' side), and a single common opening at the other ('rough') side. This arrangement is consistent with the molecular structures recently determined at high resolution by X-ray crystallography for three other porins after detergent solubilization, and implies that the Bordetella pertussis porin may have the same kind of folding. Surface relief maps calculated from electron micrographs of cell envelopes contrasted by unidirectional shadowing clearly show that the side with single opening (i.e. the rough side) represents the external surface. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cell membranes
KW - Bordetella pertussis
KW - Molecular structure
KW - Protein folding
KW - Cells
N1 - Accession Number: 16579392; Kocsis, E. 1; Trus, B. L. 1,2; Steven, A. C. 1; Smith, P. R. 3; Hannah, J. H. 4; Brennan, M. J. 4; Kessel, M. 5,6; Affiliations: 1: Laboratory of Structural Biology, National institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA; 2: Computer Systems Laboratory, Division of Computer Research and Technology, National institutes of Health, Bethesda, Maryland 20892, USA; 3: Department of Cell Biology, New York University Medical School New York, New York 10016, USA; 4: Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland 20892, USA; 5: Department of Membrane and Ultrastructure Research, Hebrew University-Hadassah Medical School, Jerusalem 91-010, Israel; 6: Department of Microbiology, University of Maryland, College Park, Maryland 20742, USA; Issue Info: Aug1993, Vol. 9 Issue 3, p469; Thesaurus Term: Cell membranes; Subject Term: Bordetella pertussis; Subject Term: Molecular structure; Subject Term: Protein folding; Subject Term: Cells; Number of Pages: 8p; Illustrations: 5 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1994-01269-001
AN - 1994-01269-001
AU - Lockhart, Susan J.
AU - Beck, Kenneth H.
AU - Summons, Terry G.
T1 - Impact of higher alcohol prices on alcohol-related attitudes and perceptions of suburban, middle-class youth.
JF - Journal of Youth and Adolescence
JO - Journal of Youth and Adolescence
Y1 - 1993/08//
VL - 22
IS - 4
SP - 441
EP - 453
CY - Germany
PB - Springer
SN - 0047-2891
SN - 1573-6601
N1 - Accession Number: 1994-01269-001. Partial author list: First Author & Affiliation: Lockhart, Susan J.; US Public Health Service, Indian Health Service Office of Human Resources, Rockville, MD, US. Release Date: 19940101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Attitudes; Alcohol Drinking Patterns; Behavior Change; Costs and Cost Analysis; Human Sex Differences. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: Aug, 1993.
AB - Explored how federal tax increases on alcoholic beverages were perceived by various categories of drinking students, as well as by gender. An anonymous survey questionnaire was administered to 1,360 9th–12th grade students (660 females, 671 males) to obtain data on Ss' backgrounds, current use of alcohol and other drugs, the social context of their drinking, preferred sources of information on alcohol and other drugs, and perceptions of both alcohol advertisements and alcohol prices. Survey data lend support to previous research (D. Coate and M. Grossman, 1988; P. J. Cook, 1981; and Cook and G. Tauchen, 1982) showing that higher alcohol prices contribute to lower alcohol consumption by youth, as well as to a decrease in related problems such as driving while intoxicated. Results also suggest that a price of around $7.50 for a 6-pack of beer or a 4-pack of wine coolers would discourage purchases by youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex & drinking level & higher alcohol prices
KW - perceived changes in own vs peer alcohol drinking behavior & attitudes
KW - 9th–12th graders
KW - 1993
KW - Alcohol Drinking Attitudes
KW - Alcohol Drinking Patterns
KW - Behavior Change
KW - Costs and Cost Analysis
KW - Human Sex Differences
KW - 1993
DO - 10.1007/BF01537723
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
T1 - Hospital Resource Utilization by American Indians/Alaska Natives for Alcoholism and Alcohol Abuse.
AU - Hisnanick, John J.
AU - Erickson, Patricia M.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1993/09//
VL - 19
IS - 3
SP - 387
EP - 396
SN - 00952990
N1 - Accession Number: 9409010050; Author: Hisnanick, John J.: 1 Author: Erickson, Patricia M.: 1 ; Author Affiliation: 1 Indian Health Service, Office cf Health Programs Research and Development U.S. Department of Health and Human Services 7900 S. J. Stock Rd., Tucson, Arizona 85746.; No. of Pages: 10; Language: English; Publication Type: Article; Update Code: 20050912
N2 - Previous work examining the issue of alcoholism and alcohol abuse among American Indians and Alaska Natives can be broadly categorized as either descriptions of the consumption patterns and behaviors of specific tribes or mortality studies, focusing on deaths due to alcoholism, alcohol abuse, chronic liver disease, or cirrhosis. A major shortcoming of previous studies has been that they have not looked at the burden this problem has imposed upon the system of health care delivery for this minority population. By using an International Classification of Diseases, Ninth Revision, Clinical Modification taxonomy of diagnostic codes developed by the National Institute on Alcoholism and Alcohol Abuse (NIAAA) and the national Indian Health Service (IHS) inpatient database for direct and contract admissions, utilization patterns for 43 IHS facilities were investigated. The period of study was 1980-1988, and our case definition included any individual 14 years and older who had any mention upon discharge of an alcohol-related diagnosis (ARD). For the 9-year period under investigation, 43,302 adult inpatient admissions occurred at the 43 IHS facilities for ARD. These admissions accounted for an overall estimated per annum rate of 13.7% of the adult inpatient days. In addition, age and gender specific discharge rates for ARD were estimated and compared to reported ARD discharge rates of the United States civilian population prepared by the NIAAA using the National Hospital Discharge Survey over the period 1979-1988. In contrast, the IHS discharge rates for ARD were three times greater than reported ARD discharge rates for the United States civilian population ABSTRACT FROM AUTHOR
KW - *ALCOHOLISM
KW - *SUBSTANCE abuse
KW - *DRUG abuse
KW - *ADDICTIONS
KW - NATIVE Americans
KW - CONTROLLED drinking
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Rubin, Carol Hogfoss
AU - Burnett, Carol A.
AU - William E. Halperin
AU - Seligman, Paul J.
T1 - Occupation as a Risk Identifier for Breast Cancer.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/09//
VL - 83
IS - 9
M3 - Article
SP - 1311
EP - 1315
PB - American Public Health Association
SN - 00900036
AB - Objectives. Breast cancer mortality may be reduced if the disease is detected early through targeted screening programs. Current screening guidelines are based solely on a woman's age. Because working populations are accessible for intervention, occupational identification may be a way of helping to define and locate risk groups and target prevention. Methods. We used a database consisting of 2.9 million occupationally coded death certificates collected from 23 states between 1979 and 1987 to calculate age-adjusted, race-specific proportionate mortality ratios for breast cancer according to occupation. We performed case-control analyses on occupational groups and on stratifications within the teaching profession. Results. We found a number of significant associations between occupation and frequency of breast cancer. For example, white female professional, managerial, and clerical workers all had high proportions of breast cancer death. High rates of breast cancer in teachers were found in both proportionate mortality ratio and case-control analyses. Conclusions. These findings may serve as in an aid in the effective targeting of work-site health promotion programs. They suggest that occupationally coded mortality data can be a useful adjunct in the difficult task of identifying groups at risk of preventable disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Breast cancer
KW - Medical screening
KW - Employee health promotion
KW - Mortality
N1 - Accession Number: 9401110384; Rubin, Carol Hogfoss 1; Burnett, Carol A. 1; William E. Halperin 1; Seligman, Paul J. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Issue Info: Sep93, Vol. 83 Issue 9, p1311; Thesaurus Term: Occupational diseases; Subject Term: Breast cancer; Subject Term: Medical screening; Subject Term: Employee health promotion; Subject Term: Mortality; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1994-07155-001
AN - 1994-07155-001
AU - Altman, Barbara M.
AU - Cunningham, Peter J.
T1 - Dynamic process of movement in residential settings.
JF - American Journal on Mental Retardation
JO - American Journal on Mental Retardation
JA - Am J Ment Retard
Y1 - 1993/09//
VL - 98
IS - 2
SP - 304
EP - 316
CY - US
PB - American Assn on Mental Retardation
SN - 0895-8017
SN - 1943-362X
N1 - Accession Number: 1994-07155-001. PMID: 8398089 Other Journal Title: American Journal of Mental Deficiency; American Journal on Intellectual and Developmental Disabilities. Partial author list: First Author & Affiliation: Altman, Barbara M.; US Dept of Health & Human Services, Public Health Service Agency for Health Care Policy & Research, Rockville, MD, US. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 19940201. Correction Date: 20101213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Migration; Living Arrangements; Residential Care Institutions; Intellectual Development Disorder. Minor Descriptor: Community Facilities. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: Sep, 1993.
AB - Findings from the 1987 National Medical Expenditure Survey of 4,480 residents show that almost 16% of individuals who spent some time in a residential facility during 1987 moved into other living arrangements during 1987. A smaller number had multiple moves during that period. Most movement that occurred was between residential facilities of the same type. For the most part, individuals ended the year in the same type of residential setting where they began the year. These findings suggest that there is considerably more mobility among residential populations than can be observed by examining annual rates of change in residential populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - degree of movement between residential settings
KW - mentally retarded clients
KW - 1987
KW - 1993
KW - Human Migration
KW - Living Arrangements
KW - Residential Care Institutions
KW - Intellectual Development Disorder
KW - Community Facilities
KW - 1993
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1994-15317-001
AN - 1994-15317-001
AU - Fields, Kay L.
AU - Price, Alan R.
T1 - Problems in research integrity arising from misconceptions about the ownership of research.
JF - Academic Medicine
JO - Academic Medicine
JA - Acad Med
Y1 - 1993/09//
VL - 68
IS - 9
SP - S60
EP - S64
CY - US
PB - Lippincott Williams & Wilkins
SN - 1040-2446
SN - 1938-808X
N1 - Accession Number: 1994-15317-001. PMID: 8373493 Other Journal Title: Journal of Medical Education. Partial author list: First Author & Affiliation: Fields, Kay L.; US Public Health Service Office of Research Integrity, Div of Research Investigations, Rockville, MD, US. Release Date: 19940401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Ethics; Experimentation; Ownership; Professional Ethics. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Page Count: 5. Issue Publication Date: Sep, 1993.
AB - Suggests that many of the allegations of scientific misconduct that are perceived by the complainants as the 'theft' of ideas originate in misconceptions about the ownership of publicly supported scientific research. The origins of this attitude toward data and the ways that the structures of university laboratories and training programs lead to confusion and misunderstandings of researchers' 'rights' to data are discussed. Also, emotional and personality factors often complicate these issues and lead to confrontations. Other misconceptions widely held among researchers include the false concepts of 'my grant' and the 'co-principal' investigator, ideas about who is and is not qualified to be an author, and ideas about sharing data. The importance of scientifically literate legal advisors is emphasized, as is the necessity for graduate students, postdoctoral fellows, and professors to understand their institutions' and grantors' guidelines and their obligations as scientists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - misconceptions about ownership of research & allegations of scientific misconduct
KW - 1993
KW - Experimental Ethics
KW - Experimentation
KW - Ownership
KW - Professional Ethics
KW - 1993
DO - 10.1097/00001888-199309000-00037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-15317-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Stout, Nancy
T1 - The Methodology of Fatal Occupational Injury Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/10//
VL - 83
IS - 10
M3 - Letter
SP - 1492
EP - 1492
PB - American Public Health Association
SN - 00900036
AB - A response by Nancy Stout to a letter to the editor about his article on methods of conducting fatal occupational injury surveillance is presented.
KW - Letters to the editor
KW - Investigations
N1 - Accession Number: 19889612; Stout, Nancy 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Rd, Morgantown, WV 26505; Issue Info: Oct93, Vol. 83 Issue 10, p1492; Subject Term: Letters to the editor; Subject Term: Investigations; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Saxton, Wilbur
AU - Newton, Richard
AU - Rorberg, Julie
AU - Sutton, Jim
AU - Johnson, Lloyd
T1 - Polycyclic aromatic hydrocarbons in seafood from the gulf of Alaska following a major crude oil spill.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1993/10//
VL - 51
IS - 4
M3 - Article
SP - 515
EP - 522
SN - 00074861
AB - The article presents a study which examined the polycyclic aromatic hydrocarbons (PAHs) in seafood from the Gulf of Alaska, following the Prudo Bay crude oil spill in 1989. It says that data for each collected sample includes date caught, specific location of the catch, and environmental conditions. Results show that exposure to crude oil was not attributable to contamination or that contaminants were rapidly metabolized in the edible tissue.
KW - Polycyclic aromatic hydrocarbons -- Environmental aspects
KW - Seafood -- Contamination
KW - Oil spills -- Environmental aspects
KW - Petroleum
KW - Shellfish as food -- Contamination
KW - Alaska, Gulf of (Alaska)
KW - Alaska
N1 - Accession Number: 70790595; Saxton, Wilbur 1; Newton, Richard 1; Rorberg, Julie 1; Sutton, Jim 1; Johnson, Lloyd 1; Affiliations: 1: U.S. Food and Drug Administration, 98041-3012 Bothell USA; Issue Info: Oct1993, Vol. 51 Issue 4, p515; Thesaurus Term: Polycyclic aromatic hydrocarbons -- Environmental aspects; Thesaurus Term: Seafood -- Contamination; Thesaurus Term: Oil spills -- Environmental aspects; Thesaurus Term: Petroleum; Thesaurus Term: Shellfish as food -- Contamination; Subject: Alaska, Gulf of (Alaska); Subject: Alaska; NAICS/Industry Codes: 424710 Petroleum Bulk Stations and Terminals; NAICS/Industry Codes: 211111 Crude Petroleum and Natural Gas Extraction; NAICS/Industry Codes: 424720 Petroleum and Petroleum Products Merchant Wholesalers (except Bulk Stations and Terminals); NAICS/Industry Codes: 486110 Pipeline Transportation of Crude Oil; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/BF00192166
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Scheman, C
T1 - Patient information and education about drugs: the FDA perspective
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1993/10//Oct-Dec 1993
VL - 27
IS - 4
M3 - Article
SP - 1133
EP - 1136
SN - 00928615
AB - Patient information and education is high on the Food and Drug Administration's (FDA) agenda. This paper reviews FDA's role in patient information and education, including a recent campaign to improve communications between health care practitioners and patients. Also covered are the problems and solutions being developed for off-label usage, additional labeling indications, direct-to-consumer-advertising, and adverse events reporting.
KW - Drug information
KW - Federal government
KW - Patients
N1 - Accession Number: ISTA2900572; Scheman, C 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: Oct-Dec 1993, Vol. 27 Issue 4, p1133; Note: Update Code: 2900; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Author-Supplied Keyword: Patients; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Kim, Insun
AU - Yetley, Elizabeth A.
AU - Calvo, Mona S.
T1 - Variations in iron-status measures during the menstrual cycle.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1993/11//
VL - 58
IS - 5
M3 - Article
SP - 705
EP - 709
SN - 00029165
AB - To determine whether normal physiologic changes associated with hormone fluctuations over the menstrual cycle affect concentrations of iron-status indicators, we examined data from 1712 women aged 18-44 y from the Second National Health and Nutrition Examination Survey (NHANES II) after adjusting for potential confounders. Adjusted mean values of hemoglobin (Hb), transferrin saturation (TS), and serum ferritin (SF) were lowest for women whose blood was drawn during menses and highest for women examined in luteal or late luteal phase of the menstrual cycle (Hb = 130 vs 133 g/L; TS = 2 1.2% vs 24.8%, P < 0.01 for both; and SF 17.2 vs 24.0 µg/L. P < 0.05). The prevalence estimate of impaired iron status was significantly higher for women whose blood was drawn during the menstrual phase than for women whose blood was drawn during the luteal and late luteal phases. Our findings suggest that the phases of the menstrual cycle affect the concentration or values of iron-status indicators. These cyclic variations in indicators of iron status are a potential source of error when iron status is assessed in large population surveys that include women of reproductive age. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Health & Nutrition Examination Survey
KW - Women
KW - Iron in the blood
KW - Menstrual cycle
KW - Hemoglobin
KW - ferritin
KW - hemoglobin
KW - Iron
KW - menstruation
KW - NHANES II
KW - transferrin saturation
N1 - Accession Number: 94404116; Kim, Insun 1,2; Yetley, Elizabeth A. 1,2; Calvo, Mona S. 1,2; Affiliations: 1: Public Health Practice Staff, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta; 2: Office of Special Nutnitionals and Office of Premarket Approval, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Issue Info: Nov1993, Vol. 58 Issue 5, p705; Thesaurus Term: HEALTH; Subject Term: Health & Nutrition Examination Survey; Subject Term: Women; Subject Term: Iron in the blood; Subject Term: Menstrual cycle; Subject Term: Hemoglobin; Author-Supplied Keyword: ferritin; Author-Supplied Keyword: hemoglobin; Author-Supplied Keyword: Iron; Author-Supplied Keyword: menstruation; Author-Supplied Keyword: NHANES II; Author-Supplied Keyword: transferrin saturation; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nutting, Paul A.
AU - Freeman, William L.
AU - Risser, David R.
AU - Helgerson, Steven D.
AU - Paisano, Roberta
AU - Hisnanick, John
AU - Beaver, Shelli K.
AU - Peters, Irene
AU - Carney, John P.
AU - Speers, Marjorie A.
T1 - Cancer Incidence among American Indians and Alaska Natives, 1980 through 1987.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/11//
VL - 83
IS - 11
M3 - Article
SP - 1589
EP - 1598
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study uses Indian Health Service inpatient data to estimate cancer incidence among American Indians and Alaska Natives. Methods. Hospital discharge data for 1980 through 1987 were used to identify cases of cancer for 21 sites in women and 18 sites in men. Estimates of incidence were directly standardized to data from the Surveillance, Epidemiology, and End Results Program for the same time frame. Results. Cancers of the gallbladder, kidney, stomach, and cervix show generally high rates among many American Indian and Alaska Native communities, and cancers of the liver and nasopharynx are high in Alaska. Of the relatively common cancers in Whites, American Indians and Alaska Natives experience lower rates for cancers of the breast, uterus, ovaries, prostate, lung, colon, rectum, and urinary bladder and for leukemia and melanoma. Variation among geographic areas and among tribal groups is observed for many important cancer sites. Conclusions. This study demonstrates significant variations of cancer rates among American Indians and Alaska Natives, with important implications for Indian Health Service cancer control programs. The study also supports the potential use of hospital discharge data for estimating chronic disease among diverse American Indian and Alaska Native communities. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Native Americans
KW - Gallbladder -- Cancer
KW - Kidneys -- Cancer
KW - Stomach -- Cancer
KW - Cervical cancer
KW - Liver -- Cancer
KW - Nasopharynx
KW - United States. Indian Health Service
N1 - Accession Number: 9402235305; Nutting, Paul A. 1,2; Freeman, William L. 3; Risser, David R. 4; Helgerson, Steven D. 5; Paisano, Roberta 6; Hisnanick, John 3; Beaver, Shelli K. 7; Peters, Irene 7; Carney, John P. 3; Speers, Marjorie A. 8; Affiliations: 1: Ambulatory Sentinel Practice Network; 2: Department of Family Medicine, University of Colorado Health Sciences Center, Denver; 3: Office of Health Program Research and Development, Indian Health Services, Tucson, Ariz.; 4: Division of Medical System Research and Development, Office of Health Program Research and Development, Albuquerque, NM; 5: Health Care Financing Administration, Seattle, Wash.; 6: Cancer Prevention and Control Program, Indian Health Service Headquarters West, Albuquerque, NM; 7: Research Program, Indian Health Service, Albuquerque, NM; 8: Division of Chronic Disease Control and Community Intervention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Ga.; Issue Info: Nov93, Vol. 83 Issue 11, p1589; Thesaurus Term: HEALTH; Subject Term: Native Americans; Subject Term: Gallbladder -- Cancer; Subject Term: Kidneys -- Cancer; Subject Term: Stomach -- Cancer; Subject Term: Cervical cancer; Subject Term: Liver -- Cancer; Subject Term: Nasopharynx ; Company/Entity: United States. Indian Health Service; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107478524
T1 - Quality of laboratory performance in testing for human immunodeficiency virus type 1 antibody: identification of variables associated with laboratory performance.
AU - Hancock JS
AU - Taylor RN
AU - Johnson CA
AU - Gerber AR
AU - Schalla WO
Y1 - 1993/11//1993 Nov
N1 - Accession Number: 107478524. Language: English. Entry Date: 19931201. Revision Date: 20150712. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7607091.
KW - Laboratories -- Evaluation
KW - AIDS Serodiagnosis -- Standards
KW - AIDS Serodiagnosis -- Evaluation
KW - Quality of Care Research
KW - Surveys
KW - Data Analysis, Statistical
KW - Odds Ratio
KW - Multivariate Analysis
KW - Diagnostic Errors -- Evaluation
KW - Data Analysis Software
KW - Human
SP - 1148
EP - 1155
JO - Archives of Pathology & Laboratory Medicine
JF - Archives of Pathology & Laboratory Medicine
JA - ARCH PATHOL LAB MED
VL - 117
IS - 11
CY - Northfield, Illinois
PB - College of American Pathologists
SN - 0003-9985
AD - Laboratory Practice Assessment Branch, Div Laboratory Systems, Public Health Practice Program Office, Ctrs Disease Control Prevention, Public Health Service, US Dept Health Human Services, Atlanta GA
U2 - PMID: 8239938.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105850903
T1 - Traumatic fatalities at work. American Indians and Alaska natives, 1980 through 1988.
AU - Sugarman JR
AU - Stout N
AU - Layne LA
Y1 - 1993/11//
N1 - Accession Number: 105850903. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807.
KW - Accidents, Occupational
KW - Cause of Death
KW - Eskimos -- Statistics and Numerical Data
KW - Native Americans -- Statistics and Numerical Data
KW - Adolescence
KW - Adult
KW - Aged
KW - Alaska
KW - Death Certificates
KW - Female
KW - Male
KW - Middle Age
KW - United States
SP - 1117
EP - 1122
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
JA - J OCCUP MED
VL - 35
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0096-1736
AD - Portland Area Indian Health Service, Division of Research, Evaluation, and Epidemiology, Seattle, WA 98121.
U2 - PMID: 8295036.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107477808
T1 - Teenage pregnancy: identifying the scope of the problem.
AU - Attico NB
AU - Hartner JA
Y1 - 1993/11//1993 Nov-Dec
N1 - Accession Number: 107477808. Language: English. Entry Date: 19931201. Revision Date: 20150712. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8805848.
KW - Pregnancy in Adolescence
KW - Pregnancy in Adolescence -- Evaluation -- United States
KW - Pregnancy in Adolescence -- Prevention and Control -- United States
KW - Adolescence
KW - Female
KW - Pregnancy
KW - United States
KW - Adoption
KW - Adolescent Mothers
KW - Adolescent Fathers
KW - Health Education -- In Adolescence
SP - 711
EP - 718
JO - Journal of the American Academy of Physician Assistants
JF - Journal of the American Academy of Physician Assistants
JA - J AM ACAD PHYSICIAN ASSIST
VL - 6
IS - 10
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
AB - The number of women younger than 19 who become pregnant each year in the United States and the associated effects of such pregnancies -- both personal and societal -- are staggering. The young mother experiences an interruption in education, often is economically disadvantaged, and more likely than not will become pregnant again before she is 19. A trickle down effect is evident, as well, with children of teenaged mothers encountering more difficulty in academic pursuits, among other problems. Preventive measures are multifaceted: education remains the cornerstone. The primary care provider, by offering education and supporting the development of community programs, can be a pivotal figure in the prevention of teenage pregnancy.
SN - 0893-7400
AD - Phoenix Area Indian Health Service, 3738 N 16th St, Ste A, Phoenix AZ 85016-5981
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107477807
T1 - Putting prevention into practice: challenges and opportunities for PAs.
AU - Griffith HM
AU - Dickey LL
Y1 - 1993/11//1993 Nov-Dec
N1 - Accession Number: 107477807. Language: English. Entry Date: 19931201. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8805848.
KW - Preventive Health Care
KW - Physician Assistants
KW - Health Services Accessibility
KW - Primary Health Care
SP - 719
EP - 721
JO - Journal of the American Academy of Physician Assistants
JF - Journal of the American Academy of Physician Assistants
JA - J AM ACAD PHYSICIAN ASSIST
VL - 6
IS - 10
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
AB - With the advent of health care reform, delivery of clinical preventive services by primary care providers is receiving renewed emphasis. Studies indicate that most primary care providers do not provide preventive services as recommended. Some of the barriers to the delivery of clinical preventive services, such as uncertainty about who should receive the services and how often, have been reduced with the help of existing programs, such as the development of clinical preventive services guidelines. The Put Prevention Into Practice program will help PAs and other primary care providers remove additional barriers and improve the delivery of clinical preventive services.
SN - 0893-7400
AD - Office Disease Prevention Health Promotion, US Public Health Service, Dept Health Human Services, Washington DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nair, Jaygopal
AU - Rouse, David A.
AU - Bai, Gill-Han
AU - Morris, Sheldon L.
T1 - The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1993/11//
VL - 10
IS - 3
M3 - Article
SP - 521
EP - 527
PB - Wiley-Blackwell
SN - 0950382X
AB - The recent emergence of indolent and rapidly fatal drug-resistant strains of Mycobacterium tuberculosis has renewed interest in defining the molecular mechanisms of drug resistance in the tubercle bacilli. In this report, we have examined the mechanism of resistance to streptomycin (Sm) in M. tuberculosis through the cloning and nucleotide sequence analysis of the gene encoding the ribosomal $12 protein (rpsL gene) from streptomycin-resistant strains and their streptomycin-sensitive parental strains. We have demonstrated that five singly SmR M. tuberculosis strains and an SmR isolate that has reduced sensitivity to multiple antibiotics have identical point mutations at codon 43 of the rpsL gene. Mutations at this same site confer SmR in Escherichia coli . In contrast, two other multiple drug-resistant M. tuberculosis strains that are resistant to Sm have rpsL genes that have the same nucleotide sequence as their drug-sensitive parent strains, suggesting that different resistance mechanisms are involved in these strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ribosomes
KW - Mycobacterium tuberculosis
KW - Mycobacterial diseases
KW - Drug resistance in microorganisms
KW - Streptomycin
KW - Nucleotide sequence
N1 - Accession Number: 16582736; Nair, Jaygopal 1; Rouse, David A. 1; Bai, Gill-Han 2; Morris, Sheldon L. 1; Affiliations: 1: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA; 2: The Korean Institute of Tuberculosis, The Korean National Tuberculosis Association, 14 Umyon-dong, Socho-ku, Seoul 137-140, Korea; Issue Info: Nov1993, Vol. 10 Issue 3, p521; Thesaurus Term: Ribosomes; Subject Term: Mycobacterium tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Drug resistance in microorganisms; Subject Term: Streptomycin; Subject Term: Nucleotide sequence; Number of Pages: 7p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bowman, Barbara A.
AU - Forbes, Allan L.
AU - White, John S.
AU - Glinsmann, Walter H.
T1 - Introduction.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1993/11/02/Nov1993 Supplement
M3 - Article
SP - 721S
EP - 723S
SN - 00029165
AB - An introduction is presented in which the editor discusses various reports within the issue on topics including fructose metabolism, role of fructose as a suppressor of food intake, and public health significance of dietary fructose.
KW - Food consumption
KW - Fructose
N1 - Accession Number: 94403268; Bowman, Barbara A. 1,2,3,4; Forbes, Allan L. 1,2,3,4; White, John S. 1,2,3,4; Glinsmann, Walter H. 1,2,3,4; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta; 2: Allan L Forbes, Inc, Rockville, MD; 3: AE Staley Manufacturing Company, Decatur, IL; 4: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC; Issue Info: Nov1993 Supplement, p721S; Thesaurus Term: Food consumption; Subject Term: Fructose; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Glinsmann, Walter H.
AU - Bowman, Barbara A.
T1 - The public health significance of dietary fructose.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1993/11/02/Nov1993 Supplement
M3 - Article
SP - 820S
EP - 823S
SN - 00029165
AB - It is increasingly appreciated that some foods and food components, including fructose, have specific health benefits and/or potential risks. This recognition is associated with varied health claims and cautionary statements that can drive dynamic changes in food manufacture, selection, consumption, and views about food safety. It is imperative that the scientific and public health communities develop clear standards for evaluating potential benefits and risks, a process for accurately conveying sound public health information to consumers, and a mechanism for monitoring future changes in the food supply and relating these changes to potential health effects. In this paper we discuss specific and general considerations about the health effects of dietary fructose and provide a perspective on their public health significance. On the basis of currently available information, there is little basis for recommending increased or decreased use of fructose in the general food supply or in products for special dietary use. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Dietary supplements
KW - Food -- Safety measures
KW - Food industry
KW - Fructose
KW - adverse effects
KW - Dietary fructose
KW - fructose safety
KW - health effects
KW - public health
N1 - Accession Number: 94403281; Glinsmann, Walter H. 1,2; Bowman, Barbara A. 1,2; Affiliations: 1: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC; 2: Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta; Issue Info: Nov1993 Supplement, p820S; Thesaurus Term: Public health; Thesaurus Term: Dietary supplements; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food industry; Subject Term: Fructose; Author-Supplied Keyword: adverse effects; Author-Supplied Keyword: Dietary fructose; Author-Supplied Keyword: fructose safety; Author-Supplied Keyword: health effects; Author-Supplied Keyword: public health; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105714902
T1 - Actual causes of death in the United States.
AU - McGinnis JM
AU - Foege WH
AU - McGinnis, J M
AU - Foege, W H
Y1 - 1993/11/10/
N1 - Accession Number: 105714902. Language: English. Entry Date: 20081212. Revision Date: 20161112. Publication Type: journal article; research. Commentary: Blackman P H. Actual causes of death in the United States. (JAMA) 3/2/94; 271 (9): 659-660. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Cause of Death
KW - Mortality
KW - Accidents, Traffic
KW - Alcohol Drinking
KW - Communicable Diseases -- Mortality
KW - Data Collection
KW - Diet
KW - Environmental Pollutants
KW - Firearms -- Statistics and Numerical Data
KW - Physical Fitness
KW - Sexuality
KW - Smoking -- Mortality
KW - Substance Use Disorders -- Mortality
KW - United States
KW - Human
SP - 2207
EP - 2212
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 270
IS - 18
CY - Chicago, Illinois
PB - American Medical Association
AB - Objective: To identify and quantify the major external (nongenetic) factors that contribute to death in the United States.Data Sources: Articles published between 1977 and 1993 were identified through MEDLINE searches, reference citations, and expert consultation. Government reports and complications of vital statistics and surveillance data were also obtained.Study Selection: Sources selected were those that were often cited and those that indicated a quantitative assessment of the relative contributions of various factors to mortality and morbidity.Data Extraction: Data used were those for which specific methodological assumptions were stated. A table quantifying the contributions of leading factors was constructed using actual counts, generally accepted estimates, and calculated estimates that were developed by summing various individual estimates and correcting to avoid double counting. For the factors of greatest complexity and uncertainty (diet and activity patterns and toxic agents), a conservative approach was taken by choosing the lower boundaries of the various estimates.Data Synthesis: The most prominent contributors to mortality in the United States in 1990 were tobacco (an estimated 400,000 deaths), diet and activity patterns (300,000), alcohol (100,000), microbial agents (90,000), toxic agents (60,000), firearms (35,000), sexual behavior (30,000), motor vehicles (25,000), and illicit use of drugs (20,000). Socioeconomic status and access to medical care are also important contributors, but difficult to quantify independent of the other factors cited. Because the studies reviewed used different approaches to derive estimates, the stated numbers should be viewed as first approximations.Conclusions: Approximately half of all deaths that occurred in 1990 could be attributed to the factors identified. Although no attempt was made to further quantify the impact of these factors on morbidity and quality of life, the public health burden they impose is considerable and offers guidance for shaping health policy priorities.
SN - 0098-7484
AD - US Department of Health and Human Services, Washington, DC 20201
AD - US Department of Health and Human Services, Washington, DC 20201.
U2 - PMID: 8411605.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Acquired Immunodeficiency Syndrome in the United States Associated with Injecting Drug Use, 1981-1991.
AU - Nwanyanwu, Okey C.
AU - Chu, Susan Y.
AU - Green, Timothy A.
AU - Buehler, James W.
AU - Berkelman, Ruth L.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1993/12//
VL - 19
IS - 4
SP - 399
EP - 408
SN - 00952990
N1 - Accession Number: 9409090164; Author: Nwanyanwu, Okey C.: 1 Author: Chu, Susan Y.: 1 Author: Green, Timothy A.: 1 Author: Buehler, James W.: 1 Author: Berkelman, Ruth L.: 1 ; Author Affiliation: 1 Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.; No. of Pages: 10; Language: English; Publication Type: Article; Update Code: 20050912
N2 - As of June 30, 1991, 182, 834 AIDS cases in the United States had been reported to the Centers for Disease Control, of which 58.879 (32.2%) were associated with illicit drug use. Of these, 39,904 (70.0%) were in both women and heterosexual men reported as injecting drug users (IDUs), 11.823 (20.7%) in men who have sex with men who are also IDUs, 5,305 (9.3%) in sex partners of IDUs, and 1,847 (3.1 %) in children whose mothers were either IDUs or sex partners of IDUs. From 1989 to 1990, the increase in the number of United States AIDS cases associated with IDU either directly or indirectly was higher in all regions compared with the Northeast. The highest percentage increases were in the South. U.S. territories, and the North Central. From 1989 to 1990, the percentage of AIDS cases attributed directly to IDU increased in women and men (15.3 and 5.9%. respectively); however, the increase in sex partners of IDUs was much larger (34.5% in men and 29.196 in women). Increases were also higher in sex partners of IDUs than in IDUs when compared by race/ethnicity and by region of residence. Because HIV can spread rapidly among IDUs and their sex partners, there is an immediate need for targeting effective HIV prevention messages to all IDUs and their sex partners in communities with high HIV infection rates. ABSTRACT FROM AUTHOR
KW - *AIDS (Disease)
KW - *HIV infections
KW - *DRUGS of abuse
KW - *INTRAVENOUS drug abusers
KW - *COMMUNICABLE diseases
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - NEWS
AU - Salmon, Marla E.
T1 - Editorial: Public Health Nursing--The Opportunity of a Century.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/12//
VL - 83
IS - 12
M3 - Editorial
SP - 1674
EP - 1675
PB - American Public Health Association
SN - 00900036
AB - The article discusses the importance of public health nursing in the U.S. In recent years, responsiveness has led public health nurses to take a more clinical, illness-oriented role rather than the traditional home and community-based preventive role. For more than 20 years health departments everywhere have been enticed into providing direct clinical care to people in their homes and clinics. Both public need and the revenue attached to these services have been the driving forces behind these changes. Public health nurses have been the human resource that has made these services a reality. These new assignments have diverted public health nurses from their major roles in assessment, surveillance, policy and health promotion and disease and injury prevention activities.
KW - Public health nursing
KW - Public health nurses
KW - Nurses
KW - Medical care
KW - Community health nursing
KW - United States
N1 - Accession Number: 9405270125; Salmon, Marla E. 1; Affiliations: 1: Division of Nursing, Bureau of Health Professions, Health Resources and Services Administration, US Public Health Service; Issue Info: Dec1993, Vol. 83 Issue 12, p1674; Subject Term: Public health nursing; Subject Term: Public health nurses; Subject Term: Nurses; Subject Term: Medical care; Subject Term: Community health nursing; Subject: United States; NAICS/Industry Codes: 621610 Home Health Care Services; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Kennedy, D. L.;
T1 - MEDW\LC/atch\UC/: FDA medical products reporting program
CT - MEDW\LC/atch\UC/: FDA medical products reporting program
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1993/12/01/
VL - 28
IS - Dec
SP - PI
EP - 52
AD - MEDWatch, Office of the Commissioner HF-2, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 30-14105; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Adverse Drug Reactions
N2 - The FDA recently announced the establishment of MEDWatch, a new program designed to monitor the safety of drugs, medical devices and other FDA-regulated products. The goal of MEDWatch is to generate more active involvement by health professionals in postmarketing surveillance. To that end, FDA wants to 1) increase awareness of drug and device-induced disease, 2) clarify what kinds of reports FDA wants to receive, 3) make it easier to report serious adverse events and product problems, and 4) reinforce the importance of reporting by keeping health professionals informed of FDA's actions.
KW - ASHP meeting abstracts--MEDWatch;
KW - Food and Drug Administration (U.S.)--MEDWatch--adverse reaction reports;
KW - Reports--drugs, adverse reactions--MEDWatch, FDA;
KW - Drugs, adverse reactions--reports--MEDWatch, FDA;
KW - Devices--medical--safety, MEDWatch reports, FDA;
KW - Safety--medical devices--reports, FDA, MEDWatch;
KW - MEDWatch--reports--adverse reactions, FDA;
KW - Administration--Food and Drug Administration--MEDWatch, adverse reaction reports;
KW - Postmarketing surveillance--drugs, adverse reactions--MEDWatch, FDA;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Minor, J. R.;
T1 - Status of HIV vaccine development
CT - Status of HIV vaccine development
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1993/12/01/
VL - 28
IS - Dec
SP - PI
EP - -7
AD - United States Public Health Service National Institutes of Health, Bethesda, MD 20892, USA
N1 - Accession Number: 30-14046; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology
N2 - In conjunction with the on-going evaluation, development, and application of antiretroviral agents, high priority is being placed on the development of a safe and effective AIDS vaccine. Although no optimal vaccine candidate has yet emerged for large-scale efficacy trials, tremendous progress has been made toward this goal, and it is predicted that such trials will begin within the next few years.
KW - Acquired immunodeficiency syndrome vaccines--immunization-;
KW - ASHP meeting abstracts--acquired immunodeficiency syndrome vaccines;
KW - Acquired immunodeficiency syndrome--immunization--vaccines, research;
KW - Immunization--acquired immunodeficiency syndrome--vaccines, research;
KW - Research--acquired immunodeficiency syndrome vaccines--immunization;
KW - Vaccines--acquired immunodeficiency syndrome--immunization;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 105851198
T1 - A call for higher standards for breast implants.
AU - Kessler DA
AU - Merkatz RB
AU - Schapiro R
AU - Kessler, D A
AU - Merkatz, R B
AU - Schapiro, R
Y1 - 1993/12//12/1/93
N1 - Accession Number: 105851198. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article; commentary. Original Study: Silicone gel breast implants. Council on Scientific Affairs, American Medical Association. (JAMA) 12/1/93; 270 (21): 2602-2606. Commentary: Finegold I. Silicone gel breast implants. (JAMA) 7/27/94; 272 (4): 271-272; Wise D M. Silicone gel breast implants. (JAMA) 7/27/94; 272 (4): 272-273. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Breast Reconstruction -- Standards
KW - Government Regulations
KW - Prostheses and Implants -- Standards
KW - Risk Assessment
KW - Silicones -- Standards
KW - American Medical Association
KW - Autonomy
KW - Equipment Safety
KW - Female
KW - Government
KW - United States
KW - United States Food and Drug Administration
SP - 2607
EP - 2608
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 270
IS - 21
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of the Commissioner, Food and Drug Administration, Rockville, MD 20857
U2 - PMID: 8230647.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105851198&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271527
T1 - Introduction: part I... Third Annual Division of Organ Transplantation Meeting.
AU - Bowen GS
Y1 - 1993/12//1993 Dec
N1 - Accession Number: 107271527. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; practice guidelines. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Health Personnel, Infected
KW - HIV Infections
KW - Practice Guidelines
KW - Centers for Disease Control and Prevention (U.S.)
KW - United States
SP - 102
EP - 103
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 3
IS - 3
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Bureau of Health Resources Development, Health Resources and Services Administration, Room 11-11, 5600 Fishers Lane, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271528
T1 - Introduction: part II... Third Annual Division of Organ Transplantation Meeting.
AU - Harmon R
Y1 - 1993/12//1993 Dec
N1 - Accession Number: 107271528. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Health Care Reform -- United States
KW - Government Agencies -- Administration
KW - United States
SP - 103
EP - 104
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 3
IS - 3
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Health Resources and Services Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271528&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271529
T1 - Federal initiatives in transplantation... Third Annual Division of Organ Transplantation Meeting.
AU - Braslow J
Y1 - 1993/12//1993 Dec
N1 - Accession Number: 107271529. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Organ Transplantation
KW - Resource Databases
KW - Registries, Organ
KW - Organ Procurement
KW - Legislation
KW - Government Regulations
KW - United States
SP - 105
EP - 108
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 3
IS - 3
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Division of Organ Transplantation, Health Resources and Services Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271529&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271549
T1 - FDA's consideration of human tissue oversight... Third Annual Division of Organ Transplantation Meeting.
AU - Taylor M
Y1 - 1993/12//1993 Dec
N1 - Accession Number: 107271549. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Organ Transplantation -- Legislation and Jurisprudence -- United States
KW - United States Food and Drug Administration
KW - Government Regulations -- United States
KW - United States
KW - Public Health
SP - 150
EP - 153
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 3
IS - 3
CY - Boulder, Colorado
PB - InnerDoorway Health Media
SN - 0905-9199
AD - Policy, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wells, Barbara L.
AU - Brown, Charles C.
AU - Horm, John W.
AU - Carleton, Richard A.
AU - Lasater, Thomas M.
T1 - Who Participates in Cardiovascular Disease Risk Factor Screenings? Experience with a Religious Organized-Based Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/01//
VL - 84
IS - 1
M3 - Article
SP - 113
EP - 115
PB - American Public Health Association
SN - 00900036
AB - Adult members who declined participation in cardiovascular disease risk factor screenings offered at religious organizations were randomly selected and asked to participate in screenings at their homes. Relationships between screening participation and sociodemographic, behavioral, and physiological measures were examined. Age, knowledge of cardiovascular disease risk factors, body mass index, current smoking status, previous report of elevated blood pressure, current diastolic blood pressure measurement, frequency of worship service attendance, and residential distance from the religious organization predictors of screening response. Those with cospicuous risk factors appeared less likely to initially respond to religious organization site screening invitations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Cardiovascular diseases
KW - Religious institutions
KW - Medical screening
KW - RISK factors
KW - Sociodemographic factors
N1 - Accession Number: 9406092486; Wells, Barbara L. 1; Brown, Charles C. 2; Horm, John W. 3; Carleton, Richard A. 4,5; Lasater, Thomas M. 6,7; Affiliations: 1: Bureau of Primary Health Care, Health Resources and Services Administration, Rockville, Md.; 2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md.; 3: Division of Health Interview Statistics, National Center for Health Statistics, Hyattsville, Md.; 4: Division of Cardiology, Memorial Hospital of Rhode Island, Pawtucket; 5: Department of Medicine, Brown University, Providence, RI; 6: Division of Health Education, Memorial Hospital of Rhode Island; 7: Department of Community Health, Brown University; Issue Info: Jan1994, Vol. 84 Issue 1, p113; Thesaurus Term: Diseases; Subject Term: Cardiovascular diseases; Subject Term: Religious institutions; Subject Term: Medical screening; Subject Term: RISK factors; Subject Term: Sociodemographic factors; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 813110 Religious Organizations; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 1995-97035-003
AN - 1995-97035-003
AU - Besteman, Karst J.
AU - Brady, Joseph V.
ED - Fletcher, Bennett W.
ED - Inciardi, James A.
ED - Horton, Arthur M.
ED - Fletcher, Bennett W., (Ed)
ED - Inciardi, James A., (Ed)
ED - Horton, Arthur M., (Ed)
T1 - Implementing mobile drug abuse treatment: Problems, procedures, and perspectives.
T2 - Drug abuse treatment: The implementation of innovative approaches.
T3 - Contributions in criminology and penology, No. 45; ISSN: 0732-4464 (Print)
Y1 - 1994///
SP - 33
EP - 42
CY - Westport, CT, US
PB - Greenwood Press/Greenwood Publishing Group
SN - 0732-4464
SN - 0-313-28906-9
N1 - Accession Number: 1995-97035-003. Partial author list: First Author & Affiliation: Besteman, Karst J.; US Public Health Service, Rockville, MD, US. Release Date: 19950601. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-313-28906-9, Hardcover. Language: English. Major Descriptor: Drug Abuse; Health Care Delivery; Methadone Maintenance. Minor Descriptor: Drug Rehabilitation; Intravenous Drug Usage. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 10.
AB - it is the objective of the Mobile Health Service . . . to examine the feasibility of delivering a range of substance abuse treatments using mobile facilities that neighborhood and community organizations find more acceptable than fixed site clinics / the focus of the project is upon the identification and recruitment of intravenous drug abusers into a mobile methadone treatment program that provides individual and group addiction counseling as well as health education, outreach, and clinical support to inner city communities with a high prevalence of substance abuse and other poor health status indicators (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - identification & recruitment into mobile methadone treatment program
KW - iv drug abusers
KW - 1994
KW - Drug Abuse
KW - Health Care Delivery
KW - Methadone Maintenance
KW - Drug Rehabilitation
KW - Intravenous Drug Usage
KW - 1994
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1994-98838-012
AN - 1994-98838-012
AU - Birman, Dina
ED - Trickett, Edison J.
ED - Watts, Roderick J.
ED - Birman, Dina
ED - Trickett, Edison J., (Ed)
ED - Watts, Roderick J., (Ed)
ED - Birman, Dina, (Ed)
T1 - Acculturation and human diversity in a multicultural society.
T2 - Human diversity: Perspectives on people in context.
T3 - The Jossey-Bass social and behavioral science series
Y1 - 1994///
SP - 261
EP - 284
CY - San Francisco, CA, US
PB - Jossey-Bass
SN - 0-7879-0029-X
N1 - Accession Number: 1994-98838-012. Partial author list: First Author & Affiliation: Birman, Dina; US Public Health Service, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Release Date: 19950501. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7879-0029-X, Hardcover. Language: English. Major Descriptor: Acculturation; Racial and Ethnic Groups; Society. Minor Descriptor: Models. Classification: Culture & Ethnology (2930). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 24.
AB - address issues of acculturation, or culture change, among members of ethnic groups in multicultural societies / propose an expanded framework of acculturation that integrates aspects of both the biculturalism and identity frameworks / [examine] theories of psychological acculturation / [describe] the biculturalism and identity frameworks . . . in the context of the distinctive population whose acculturation they were designed to address / [present] the proposed differentiated model of acculturation (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological acculturation & biculturism & identity frameworks among ethnic groups in multicultural societies
KW - 1994
KW - Acculturation
KW - Racial and Ethnic Groups
KW - Society
KW - Models
KW - 1994
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Graham, John S.
AU - Bryant, Mark A.
AU - Brave, Ernest H.
T1 - Effect of Sulfur Mustard on Mast Cells in Hairless Guinea Pig Skin.
JO - Journal of Toxicology -- Cutaneous & Ocular Toxicology
JF - Journal of Toxicology -- Cutaneous & Ocular Toxicology
Y1 - 1994/01//
VL - 13
IS - 1
M3 - Article
SP - 47
EP - 54
SN - 07313829
AB - The skin of 24 anesthetized hairless guinea pigs was exposed to saturated sulfur mustard (bis-2-chloroethyl sulfide; HD) vapor for 5 and 7 min (24 sites per exposure) using 14 mm diameter vapor cups. The animals were euthanized 24 hr after HD exposure and skin specimens were taken and fixed for morphometric evaluation for granulated mast cells with an image analysis system (IAS). A total of 32 exposure sites was taken and evaluated from four naive guinea pigs. All tissue specimens were processed in paraffin and sectioned at 5 μm. One section each was stained with Unna's stain for mast cells and hematoxylin and eosin (H&E) and evaluated by light microscopy. An average area of 6.48 × 105 μm2 of skin was examined per site with the IAS. The Unna's stain together with interference light filters on the IAS enhanced the contrast between mast cell granules and the background tissue, allowing the number of granulated mast cells to be determined. The number of pixels detected by the IAS represented the area occupied by mast cell granules. There were significantly fewer mast cells (p < 0.05) in either the 5 or 7 min HD exposure groups than in the sham-exposed animals, with significantly fewer mast cells in the 7 min HD than the 5 min HD group. There were also significantly smaller areas occupied by granules in either HD-exposed group than in sham-exposed animals. HD-induced lesions in the hairless guinea pig model have shown signs of an inflammatory response, and with their granules of vasoactive histamine, mast cells might be expected to play a role in HD-induced injury. Changes in mast cells exposed to low sulfur mustard levels, as detected by an IAS, may serve as an early marker for cutaneous damage, which might not be as easily determined with routine light microscopic examination. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 78466762; Graham, John S. 1; Bryant, Mark A. 2; Brave, Ernest H. 1; Affiliations: 1: U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground, Maryland; 2: Division of Pathology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Issue Info: 1994, Vol. 13 Issue 1, p47; Number of Pages: 8p; Document Type: Article
L3 - 10.3109/15569529409037509
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-06480-016
AN - 2006-06480-016
AU - Flynn, Brian W.
T1 - Thinking the Unthinkable: Disaster Mental Health.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1994/01//
VL - 39
IS - 1
SP - 27
EP - 28
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2006-06480-016. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Flynn, Brian W.; Emergency Services and Disaster Relief Branch, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, United States Public Health Service, Rockville, MD, US. Release Date: 20061218. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Coping Behavior; Disasters; Grief; Mental Health; Thinking. Classification: Personality Traits & Processes (3120); Environmental Issues & Attitudes (4070). Population: Human (10). Reviewed Item: Hodgkinson, Peter E.; Stewart, Michael. Coping with Catastrophe: A Handbook of Disaster Management=New York: Routledge, Chapman & Hall, 1991. 230 pp. $65.00 ($81.50, Canada) hardcover, $17.95 ($22.50, Canada) paperback; 1991. Page Count: 2. Issue Publication Date: Jan, 1994.
AB - Reviews the book, Coping with Catastrophe: A Handbook of Disaster Management by Peter E. Hodgkinson and Michael Stewart (1991). This book provides a sound and relatively comprehensive overview of the psychological sequelae resulting from various types of emergencies and disasters. The reader is cautioned that it is not a handbook of disaster management, as the title states. Rather, the book deals exclusively with psychosocial issues. This book will be most helpful to mental health professionals with little exposure to disaster work. Contents include a variety of perspectives on trauma and bereavement, a broad spectrum of disaster events, and guidance for interventions with primary victims as well as disaster workers. The book is an example and a reminder of several challenges in the disaster mental health field There is a need for research-based knowledge. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health professionals
KW - disaster events
KW - disaster management
KW - disaster mental health
KW - 1994
KW - Coping Behavior
KW - Disasters
KW - Grief
KW - Mental Health
KW - Thinking
KW - 1994
U2 - Hodgkinson, Peter E.; Stewart, Michael. (1991); Coping with Catastrophe: A Handbook of Disaster Management; New York: Routledge, Chapman & Hall, 1991. 230 pp. $65.00 ($81.50, Canada) hardcover, $17.95 ($22.50, Canada) paperback; 0-415-04097-3 (Hardcover); 0-415-04098-1 (Paperback).
DO - 10.1037/033789
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06480-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Mendell, Mark J.
AU - Fine, Lawrence
T1 - Editorial: Building Ventilation and Symptoms -- Where Do We Go From Here?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/03//
VL - 84
IS - 3
M3 - Editorial
SP - 346
EP - 348
PB - American Public Health Association
SN - 00900036
AB - The article comments on the study by Jouni J.K. Jaakkola, Pekka Tuomaala and Olli Seppanen on the health aspects of mechanical ventilation of buildings in the U.S. Ventilation refers to the movement of outdoor air into a building. Its important aspect is the volumetric rate of air per person brought into a building. Other studies have examined the relationship between occupant symptoms and air ventilation rates in buildings. It was found that there was no significant symptom differences between ventilation rates.
KW - Ventilation
KW - Buildings -- Environmental engineering
KW - Air quality
KW - Environmental engineering
KW - Sanitary engineering
KW - United States
N1 - Accession Number: 9406150677; Mendell, Mark J. 1; Fine, Lawrence 1; Affiliations: 1: Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Mar1994, Vol. 84 Issue 3, p346; Thesaurus Term: Ventilation; Thesaurus Term: Buildings -- Environmental engineering; Thesaurus Term: Air quality; Thesaurus Term: Environmental engineering; Thesaurus Term: Sanitary engineering; Subject: United States; NAICS/Industry Codes: 334512 Automatic Environmental Control Manufacturing for Residential, Commercial, and Appliance Use; NAICS/Industry Codes: 562998 All Other Miscellaneous Waste Management Services; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Kennedy, Richard
AU - Veazie, Mark
AU - Conway, George
AU - Amandus, Harlan
T1 - Fishing Deaths in Alaska Vary by Fishery.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/03//
VL - 84
IS - 3
M3 - Letter
SP - 496
EP - 496
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Occupational Injury Deaths in Alaska's Fishing Industry, 1980 Through 1988," by P. G. Schnitzer and D. D. Landen, which appeared in the 1993 issue.
KW - Letters to the editor
KW - Work-related injuries
N1 - Accession Number: 20695243; Kennedy, Richard 1; Veazie, Mark; Conway, George; Amandus, Harlan; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 3601 C St, Suite 250, Anchorage, AL 99503-5929; Issue Info: Mar1994, Vol. 84 Issue 3, p496; Subject Term: Letters to the editor; Subject Term: Work-related injuries; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107408510
T1 - Key child care and other federal programs for infants and toddlers.
AU - Carroad DL
Y1 - 1994/03//
N1 - Accession Number: 107408510. Language: English. Entry Date: 19950601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; Peer Reviewed; USA. NLM UID: 0320227.
KW - Child Welfare -- United States
KW - Family Services
KW - Child Health Services
KW - United States Department of Health and Human Services
KW - United States
KW - Infant
KW - Child, Preschool
KW - Child
SP - 14
EP - 36
JO - Children Today
JF - Children Today
JA - CHILD TODAY
VL - 23
IS - 2
CY - Washington, District of Columbia
PB - Superintendent of Documents
SN - 0361-4336
AD - Office of Public Affairs, Administration for Children and Families, US Department of Health and Human Services
U2 - PMID: 7851133.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107366428
T1 - The keynote address. Research, practice, and education within the health care agenda.
AU - Bavier AR
Y1 - 1994///1994 Spring
N1 - Accession Number: 107366428. Language: English. Entry Date: 19960401. Revision Date: 20150820. Publication Type: Journal Article; proceedings. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 7707277.
KW - Health Care Reform -- United States
KW - United States
KW - Health Services Accessibility
KW - Health Care Costs
KW - Cost Savings
KW - Consumers
KW - Quality of Health Care
KW - Research, Nursing
KW - Education, Nursing
KW - Nursing Practice
SP - 1
EP - 12
JO - Communicating Nursing Research
JF - Communicating Nursing Research
JA - COMMUN NURS RES
VL - 27
CY - Boulder, Colorado
PB - Western Interstate Commission for Higher Education
SN - 0160-1652
AD - Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107443990
T1 - Nursing's role in the delivery of clinical preventive services.
AU - Griffith HM
Y1 - 1994/03//1994 Mar-Apr
N1 - Accession Number: 107443990. Language: English. Entry Date: 19940601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - Preventive Health Care
KW - Nursing Role
SP - 69
EP - 69
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 10
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 8755-7223
AD - Office Disease Prevention Health Promotion, Office Assistant Secretary Health, Public Health Service, US Dept Health Human Services, Washington DC 20201
U2 - PMID: 8027480.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Castillo, Dawn N.
AU - Landen, Deborah D.
AU - Layne, Larry A.
T1 - Occupational Injury Deaths of 16- and 17-Year-Olds in the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/04//
VL - 84
IS - 4
M3 - Article
SP - 646
EP - 649
PB - American Public Health Association
SN - 00900036
AB - Data from the National Traumatic Occupational Fatalities surveillance system were used to analyze occupational injury deaths of civilian 16- and 17-year-olds during 1980 through 1989. There were 670 deaths; the rate was 5.11 per 100,000 full-time equivalent workers. The leading causes of death were incidents involving motor vehicles and machines, electrocution, and homicide. Workers 16 and 17 years old appear to be at greater risk than adults for occupational death by electrocution, suffocation, drowning, poisoning, and natural and environmental factors. Improved enforcement of and compliance with federal child labor laws, evaluation of the appropriateness of currently permitted activities, and education are encouraged. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Work-related injuries
KW - Child labor -- Law & legislation
KW - Young workers
KW - Occupational mortality
N1 - Accession Number: 9406010244; Castillo, Dawn N. 1; Landen, Deborah D. 1; Layne, Larry A. 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV; Issue Info: Apr94, Vol. 84 Issue 4, p646; Thesaurus Term: Industrial safety; Subject Term: Work-related injuries; Subject Term: Child labor -- Law & legislation; Subject Term: Young workers; Subject Term: Occupational mortality; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Layne, Larry A.
AU - Castillo, Dawn N.
AU - Stout, Nancy
AU - Cutlip, Patricia
T1 - Adolescent Occupational Injuries Requiring Hospital Emergency Department Treatment: A Nationally Representative Sample.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/04//
VL - 84
IS - 4
M3 - Article
SP - 657
EP - 660
PB - American Public Health Association
SN - 00900036
AB - Data from a nationally representative sample of emergency departments for the 6-month period July through December 1992 were used to examine nonfatal occupational injuries sustained by adolescents aged 14 through 17 years. There were 679 occupational injuries, corresponding to an estimated 37,405 injuries nationwide. Males constituted 65.8% of the injury victims. The injury rate for males was 7.0 per 100 full-time employees, compared with 4.4 for females. Lacerations to the hand or finger accounted for 25.6% of all injuries. The majority of injuries occurred in retail trades (53.7%), which also had the highest rate (6.3 per 100 full-time employees). Seventy-one percent of the injuries in retail trade occurred in eating and drinking establishments. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Industrial safety
KW - Work-related injuries
KW - Teenagers
KW - Hospital emergency services
KW - Retail industry
N1 - Accession Number: 9406010247; Layne, Larry A. 1; Castillo, Dawn N. 1; Stout, Nancy 1; Cutlip, Patricia 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WVa.; Issue Info: Apr94, Vol. 84 Issue 4, p657; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Industrial safety; Subject Term: Work-related injuries; Subject Term: Teenagers; Subject Term: Hospital emergency services; Subject Term: Retail industry; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 452999 All other miscellaneous general merchandise stores; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kenyon, T. A.
AU - Kenyon, A. S.
AU - Sibiya, T.
T1 - Drug quality screening in developing countries: establishment of an appropriate laboratory in Swaziland.
T2 - Contrôle de la qualité des médicaments dans les pays en développement: établissement d'un laboratoire approprié au Swaziland.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1994/04//
VL - 72
IS - 4
M3 - Article
SP - 615
EP - 620
PB - World Health Organization
SN - 00429686
AB - A simple, low-cost, accurate thin-layer chromatography (TLC) method has been used to establish the first drug quality screening laboratory in Swaziland. For this purpose, office space at the central medical stores was first converted into a simple laboratory. Basic equipment, supplies, and materials were purchased, existing manpower was trained to perform accurately the TLC procedure, and a system was established for the qualitative/quantitative screening of selected drugs purchased by the Ministry of Health prior to their distribution to user facilities. The TLC method described can be used to set up similar low-cost, drug quality screening laboratories in other developing countries where analytical chemistry expertise is lacking, resources are scarce, and sophisticated analytical laboratories to assess drug quality are not available. (English) [ABSTRACT FROM AUTHOR]
AB - Cet article dé écrit le premier laboratoire de contrôle de la qualité des médicaments basé sur une technique simple, peu coûteuse et exacte de chromatographie en couche mince (TLC), qui a été établi au magasin central de fournitures médicales du Ministère de la Santé du Swaziland. Les dispensateurs locaux, qui ont reçu une instruction secondaire, ont été formés à la technique et étaient compétents au bout d'un mois de pratique. La technique n'exige qu'un matériel de laboratoire de base (appareillage, fournitures et réactifs) et peut être exécutée dans un espace restreint. On trouvera dans rarticle une liste des appareils, des fournitures et des réactifs nécessaires ainsi que les fournisseurs des substances de référence pour les analyses comparatives. Le coût de demarrage estimé d'un tel laboratoire, y compris la transformation d'un bureau en laboratoire, est d'environ US$ 5000-10 000, et le coût de fonctionnement par test est bien inférieur à US$ 1,00. A titre de comparaison, le matériel utilisé pour effectuer les analyses qualitatives/quantitatives dans la plupart des laboratoires de contrôle de la qualité des médicaments est d'environ US$ 50 000 par unité, le coût de fonctionnement par test est 20 à 50 fois plus élevé qu'avec la TLC et les techniques utilisées exigent un personnel hautement qualifié. La TLC est une technique qui convient pour le contrôle qualitatif et semi-quantitatif de divers médicaments avant leur administration aux malades. En TLC, la comparaison des taches obtenues avec l'échantillon et avec la substance de référence indique s'il s'agit du même composé, et l'intensité de chaque tache, visualisée en lumière ultraviolette ou par coloration à l'iode, permet de savoir si la teneur de l'échantillon se situe dans les 85-115% de la valeur de référence. La sensibilité et la spécificité de la TLC sont toutes deux de 98%. Les auteurs examinent la relation entre les résultats faussement positifs et la prévalence des medicaments de qualité insuffisante. Une liste de 20 médicaments testés par TLC au cours de la période de mise en service du laboratoire est donnée. Un technicien a élaboré des modes opératoires pour 8 autres médicaments dans les 6 mois qui ont suivi. La technique de TLC décrite ici devrait sensiblement améliorer l'aptitude des pays en développement à contrôler la qualité des médicaments avant de les distribuer aux services utilisateurs et aux malades. II est proposé de l'adopter comme méthode de choix pour contreler la qualité des médicaments à tous les niveaux du système de soins de santé. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drug use testing
KW - Medical screening
KW - Drug abuse
KW - Thin layer chromatography
KW - Medical laboratories
KW - Swaziland
N1 - Accession Number: 24756194; Kenyon, T. A. 1; Kenyon, A. S. 2,3; Sibiya, T. 4; Affiliations: 1: Regional Programme Director, Southern Africa, Project HOPE; 2: Medical Director, Communicable Disease Division, Department of Health, Chicago, IL, USA; 3: Chemist, U.S. Food and Drug Administration, Division of Drug Analysis, St. Louis, MO, USA; 4: Chief Pharmacist, Ministry of Health, Swaziland; Issue Info: 1994, Vol. 72 Issue 4, p615; Subject Term: Drug use testing; Subject Term: Medical screening; Subject Term: Drug abuse; Subject Term: Thin layer chromatography; Subject Term: Medical laboratories; Subject: Swaziland; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107443683
T1 - State of the art in geropsychiatric nursing.
AU - Harper M
AU - Grau L
Y1 - 1994/04//1994 Apr
N1 - Accession Number: 107443683. Language: English. Entry Date: 19940601. Revision Date: 20150818. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8200911.
KW - Geropsychiatric Nursing
KW - Mental Disorders -- Epidemiology -- In Old Age
KW - Mental Health Services -- Utilization -- In Old Age
KW - Education, Nursing
KW - Education, Continuing (Credit)
KW - Family
KW - Aged
SP - 7
EP - 41
JO - Journal of Psychosocial Nursing & Mental Health Services
JF - Journal of Psychosocial Nursing & Mental Health Services
JA - J PSYCHOSOC NURS MENT HEALTH SERV
VL - 32
IS - 4
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - Advances in management and treatment of mental disorders of the elderly point to the necessity of continuing education.
SN - 0279-3695
AD - Dept Health Human Services, Public Health Service, Alcohol Drug Abuse, Mental Health Adm, Rm 18105, Parklawn Bldg, 5600 Fishers Lane, Rockville MD 20857
U2 - PMID: 8035366.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271562
T1 - Projections in solid organ transplantation and wait list activity through the year 2000.
AU - Niemcryk SJ
AU - Aronoff R
AU - Marconi KM
AU - Bowen GS
Y1 - 1994/04//1994 Apr
N1 - Accession Number: 107271562. Language: English. Entry Date: 19980701. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Organ Transplantation -- Trends -- United States
KW - Health Services Accessibility -- Trends -- United States
KW - Forecasting (Research)
KW - Linear Regression
KW - Kidney Transplantation -- Trends -- United States
KW - Heart Transplantation -- Trends -- United States
KW - Pancreas Transplantation -- Trends -- United States
KW - Transplant Recipients
KW - Models, Statistical
KW - Resource Databases
KW - United States
KW - Human
SP - 23
EP - 30
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 4
IS - 1
CY - Boulder, Colorado
PB - InnerDoorway Health Media
AB - The disparity between the number of people on the national transplant waiting list and the number of available organs has consistently grown over the past five years. Projections through the year 2000 were made to determine whether future shortages in solid organs (kidney, liver, heart, pancreas) were likely to become worse. Past trends have been highly stable over the observed period of time. The projections indicate that the shortage of transplantable allografts is likely to worsen for each of the solid organs. Projected trends for the next 2-3 years are likely to be more accurate than they are for later years. Social, medical, and technological factors that may influence trends in donation are discussed.
SN - 0905-9199
AD - Bureau of Health Resources Development, Health Resources and Services Administration, 5600 Fishers Lane (7A-07), Parklawn Building, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107391791
T1 - The application of educational technology to occupational safety and health training.
AU - Hudock SD
Y1 - 1994/04//1994 Apr-Jun
N1 - Accession Number: 107391791. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Occupational Exposure -- Prevention and Control
KW - Occupational Health -- Education
KW - Staff Development
KW - Educational Technology
KW - Audiovisuals
KW - Computer Assisted Instruction
KW - CD ROM
KW - Education, Non-Traditional
KW - Videorecording
SP - 201
EP - 210
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 9
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - For years, lectures and films have formed the basis of health and safety training. New communication systems, however, allow trainees such luxuries as receiving instruction from a source that might be hundreds of miles away. Various multimedia systems are described, incuding CD-ROM, virtual reality, and others that may some day become the mainstays of worker training.
SN - 0885-114X
AD - Educational Resource Development Branch, Division of Training and Manpower Development, C-10, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226
U2 - PMID: 7521973.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Jenkins, Barbara
AU - Ames, Richard G.
AU - O'Malley, Michael
AU - Chrislip, David
AU - Russo, John
T1 - Chronic Neurological Sequelae to Organophosphate Pesticide Poisoning.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/05//
VL - 84
IS - 5
M3 - Article
SP - 731
EP - 736
PB - American Public Health Association
SN - 00900036
AB - Objectives. This work was undertaken to determine whether there are any chronic neurological sequelae to acute organophosphate pesticide poisoning. Methods. California surveillance data were used in a study of neurological function among 128 men poisoned by organophosphate pesticides in California from 1982 to 1990 and 90 referents. Tests included a neurological physical examination, 5 nerve conduction tests, 2 vibrotactile sensitivity tests, 10 neurobehavioral tests, and 1 postural sway test. Results. After correcting for confounding, the poisoned group performed significantly worse than the referent group on two neurobehavioral tests (sustained visual attention and mood scales). When the data were restricted to men with documented cholinesterase inhibition (n = 83) or to men who had been hospitalized (n = 36), the poisoned subjects also showed significantly worse vibrotactile sensitivity of finger and toe. Significant trends of increased impairment were found with increased days of disability on a wide spectrum of tests of both central and peripheral nerve function. Conclusions. While these findings are limited by low response rates and by small sample sizes for specific pesticides, this study was based on a large surveillance database and is the largest study to date of the chronic effects of organophosphate pesticide poisoning. The evidence of some long-term effects of poisoning is consistent with two prior studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pesticides -- Toxicology
KW - Spraying
KW - Poisons
KW - Organophosphorus compounds
KW - Public health surveillance
KW - California
N1 - Accession Number: 9406223444; Steenland, Kyle 1; Jenkins, Barbara 1; Ames, Richard G. 2; O'Malley, Michael 2; Chrislip, David 1; Russo, John 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: California Environmental Protection Agency in Berkeley and Sacramento; Issue Info: May94, Vol. 84 Issue 5, p731; Thesaurus Term: Pesticides -- Toxicology; Thesaurus Term: Spraying; Thesaurus Term: Poisons; Subject Term: Organophosphorus compounds; Subject Term: Public health surveillance; Subject: California; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Havery, D. C.;
AU - Chou, H. J.;
T1 - N-Nitrosamines in cosmetics products: overview
CT - N-Nitrosamines in cosmetics products: overview
JO - Cosmetics & Toiletries (USA)
JF - Cosmetics & Toiletries (USA)
Y1 - 1994/05/01/
VL - 109
IS - May
SP - 53
EP - 62
SN - 03614387
AD - Reprints: Cosmetics & Toiletries, 362 S. Schmale Rd., Carol Stream, IL 60188-2787, USA
AD - U.S. Food and Drug Administration, Washington, DC, USA
N1 - Accession Number: 31-09388; Language: English; References: 53; Publication Type: Review; Journal Coden: CTOIDG; Section Heading: Pharmacology; Abstract Author: Ellen Katz Neumann
N2 - A review is presented of the occurrence, formation, measurement, and regulation of N-nitrosamines in cosmetic products.
KW - N-Nitrosamines--cosmetics--review;
KW - Cosmetics--N-nitrosamines--review;
KW - Regulations--cosmetics--N-nitrosamines, review;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107412834
T1 - Sane holiday eating... GEM No. 239.
AU - Pelican S
Y1 - 1994/05//May/Jun94
N1 - Accession Number: 107412834. Language: English. Entry Date: 19950701. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. NLM UID: 0246004.
KW - Energy Intake -- Evaluation
KW - Holidays
SP - 166A
EP - 166A
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
JA - J NUTR EDUC
VL - 26
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0022-3182
AD - Nutrition and Dietetics Training Program, Indian Health Service, PO Box 5558, Santa Fe, NM 87502
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1995-02384-001
AN - 1995-02384-001
AU - Doll, Lynda S.
AU - Harrison, Janet S.
AU - Frey, Robert L.
AU - McKirnan, David
AU - Bartholow, B. N.
AU - Douglas, J. M.
AU - Joy, D.
AU - Bolan, G.
AU - Doetsch, J.
T1 - Failure to disclose HIV risk among gay and bisexual men attending sexually transmitted disease clinics.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 1994/05//May-Jun, 1994
VL - 10
IS - 3
SP - 125
EP - 129
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
N1 - Accession Number: 1995-02384-001. PMID: 7917436 Partial author list: First Author & Affiliation: Doll, Lynda S.; US Dept of Health & Human Services Public Health Service, Ctrs for Disease Control & Prevention, National Ctr for Infectious Diseases, Div of HIV/AIDS, Atlanta, GA, US. Release Date: 19950101. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; Bisexuality; HIV; Male Homosexuality; Risk Taking. Classification: Immunological Disorders (3291). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. Page Count: 5. Issue Publication Date: May-Jun, 1994.
AB - Evaluated the extent and accuracy of gay and bisexual men's disclosure of risk behaviors (RBs) to staff at sexually transmitted diseases (STD) clinics. 1,063 men (aged 18–73 yrs) completed a screening assessment on unprotected anal (UAS) and oral sex (UOS), a detailed interview about sexual and drug-use behaviors, and a questionnaire about sexual identity and participation in gay-identified organizations. Data from the screening, interview, and diagnoses of STDs found on medical charts were compared to determine disclosure accuracy. Of 523 Ss who reported UAS at interview, 29% failed to report this behavior at screening. Ss who failed to disclose UAS were also less likely to disclose engaging in UOS. Ss who did not disclose RBs reported greater involvement in gay organizations, greater perceived peer support for condoms, fewer episodes of UAS, and lower rates of substance-abuse treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - disclosure of HIV related risk behaviors
KW - gay & bisexual male 18–73 yr olds attending sexually transmitted disease clinics
KW - 1994
KW - AIDS Prevention
KW - Bisexuality
KW - HIV
KW - Male Homosexuality
KW - Risk Taking
KW - 1994
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-02384-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107447869
T1 - Worksite indoor air quality management.
AU - Little SP
AU - Lewis FA
AU - Yang CS
AU - Zampiello FA
Y1 - 1994/06//1994 Jun
N1 - Accession Number: 107447869. Language: English. Entry Date: 19940801. Revision Date: 20150819. Publication Type: Journal Article; bibliography; CEU; exam questions; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669.
KW - Occupational Health Nursing -- Education
KW - Air Pollution, Indoor
KW - Occupational Health
KW - Occupational Exposure -- Prevention and Control
KW - Pennsylvania
KW - Education, Continuing (Credit)
KW - Environmental Health
KW - Information Resources
SP - 277
EP - 299
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 42
IS - 6
CY - Thorofare, New Jersey
PB - SLACK Incorporated
SN - 0891-0162
AD - United States Public Health Service, Federal Occupational Health, Region III, Philadelphia PA
U2 - PMID: 8037830.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107447869&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107447871
T1 - Chemical exposure evaluation and intervention for occupational health nurses.
AU - Hibbs BF
Y1 - 1994/06//1994 Jun
N1 - Accession Number: 107447871. Language: English. Entry Date: 19940801. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669.
KW - Occupational Health Nursing -- Education
KW - Occupational Exposure
KW - Occupational Health
KW - Work Environment
KW - Nursing Assessment -- Methods
KW - Nursing Diagnosis
KW - Nursing Interventions
KW - Hazardous Materials
KW - Georgia
KW - Education, Continuing (Credit)
KW - Environmental Health
KW - Information Resources
SP - 284
EP - 299
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 42
IS - 6
CY - Thorofare, New Jersey
PB - SLACK Incorporated
SN - 0891-0162
AD - Div Toxicology, Agency Toxic Substances Disease Registry, Public Health Service, US Dept Health Human Services, Atlanta GA
U2 - PMID: 8037831.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107447871&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107399758
T1 - Fetal alcohol syndrome: implications for dental health professionals.
AU - Haney K
AU - Bothwell E
Y1 - 1994///1994 Summer
N1 - Accession Number: 107399758. Language: English. Entry Date: 19950201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9816286.
KW - Fetal Alcohol Syndrome
KW - Dental Hygienists
KW - Professional Role
KW - Dentition -- Abnormalities
KW - Fetal Alcohol Syndrome -- Prevention and Control
KW - Fetal Alcohol Syndrome -- Etiology
KW - Patient Care
SP - 8
EP - 9
JO - Dental Hygienist News
JF - Dental Hygienist News
JA - DENT HYG NEWS
VL - 7
IS - 3
CY - Bloomfield Hills, Michigan
PB - Lally, McFarland, & Pantello
SN - 1082-9016
AD - Indian Health Service, US Public Health Service, Gallup Indian Med Ctr, Gallup NM
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107399758&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kodell, Ralph L.
AU - Chen, James J.
T1 - Reducing Conservatism in Risk Estimation for Mixtures of Carcinogens.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/06//
VL - 14
IS - 3
M3 - Article
SP - 327
EP - 332
SN - 02724332
AB - The excess cancer risk that might result from exposure to a mixture of chemical carcinogens usually must be estimated using data from experiments conducted with individual chemicals. In estimating such risk, it is commonly assumed that the total risk due to the mixture is the sum of the risks of the individual components, provided that the risks associated with individual chemicals at levels present in the mixture are low. This assumption, while itself not necessarily conservative, has led to the conservative practice of summing individual upper-bound risk estimates in order to obtain an upper bound on the total excess cancer risk for a mixture. Less conservative procedures are described here and are illustrated for the case of a mixture of four carcinogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological assay
KW - Carcinogens
KW - Bootstrapping (Statistics)
KW - Extrapolation
KW - Cancer
KW - Bioassay
KW - bootstrap
KW - Cancer risk, excess
KW - Carcinogen mixture
KW - Health risk estimation
KW - linear extrapolation
KW - Statistical method
KW - summing upper bounds
N1 - Accession Number: 8114572; Kodell, Ralph L. 1; Chen, James J. 1; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Jun94, Vol. 14 Issue 3, p327; Thesaurus Term: Biological assay; Thesaurus Term: Carcinogens; Subject Term: Bootstrapping (Statistics); Subject Term: Extrapolation; Subject Term: Cancer; Author-Supplied Keyword: Bioassay; Author-Supplied Keyword: bootstrap; Author-Supplied Keyword: Cancer risk, excess; Author-Supplied Keyword: Carcinogen mixture; Author-Supplied Keyword: Health risk estimation; Author-Supplied Keyword: linear extrapolation; Author-Supplied Keyword: Statistical method; Author-Supplied Keyword: summing upper bounds; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8114572&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Slikker Jr., William
T1 - Modeling for Risk Assessment of Neurotoxic Effects.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/06//
VL - 14
IS - 3
M3 - Article
SP - 333
EP - 338
SN - 02724332
AB - The regulation of noncancer toxicants, including neurotoxicants, has usually been based upon a reference dose (allowable daily intake). A reference dose is obtained by dividing a no-observed-effect level by uncertainty (safety) factors to account for intraspecies and interspecies sensitivities to a chemical. It is assumed that the risk at the reference dose is negligible, but no attempt generally is made to estimate the risk at the reference dose. A procedure is outlined that provides estimates of risk as a function of dose. The first step is to establish a mathematical relationship between a biological effect and the dose of a chemical. Knowledge of biological mechanisms and/or pharmacokinetics can assist in the choice of plausible mathematical models. The mathematical model provides estimates of average responses as a function of dose. Secondly, estimates of risk require selection of a distribution of individual responses about the average response given by the mathematical model. In the case of a normal or lognormal distribution, only an estimate of the standard deviation is needed. The third step is to define an adverse level for a response so that the probability (risk) of exceeding that level can be estimated as a function of dose. Because a firm response level often cannot be established at which adverse biological effects occur, it may be necessary to at least establish an abnormal response level that only a small proportion of individuals would exceed in an unexposed group. That is, if a normal range of responses can be established, then the probability (risk) of abnormal responses can be estimated. In order to illustrate this process, measures of the neurotransmitter serotonin and its metabolite 5-hydroxyindoleacetic acid in specific areas of the brain of rats and monkeys are analyzed after exposure to the neurotoxicant methylene-dioxymethamphetamine. These risk estimates are compared with risk estimates from the quantal approach in which animals are classified as either abnormal or not depending upon abnormal serotonin levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Poisons
KW - Mathematical models
KW - Toxicology
KW - Neurotoxicology
KW - benchmark dose
KW - continuous data
KW - Dose, benchmark
KW - Health risk assessmsent
KW - Model choice
KW - Neurotoxicity
KW - Risk estimation
N1 - Accession Number: 8114570; Gaylor, David W. 1; Slikker Jr., William 1; Affiliations: 1: Biometry and Risk Assessment, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jun94, Vol. 14 Issue 3, p333; Thesaurus Term: Risk assessment; Thesaurus Term: Poisons; Thesaurus Term: Mathematical models; Thesaurus Term: Toxicology; Subject Term: Neurotoxicology; Author-Supplied Keyword: benchmark dose; Author-Supplied Keyword: continuous data; Author-Supplied Keyword: Dose, benchmark; Author-Supplied Keyword: Health risk assessmsent; Author-Supplied Keyword: Model choice; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Risk estimation; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1994-39525-001
AN - 1994-39525-001
AU - Kolb, Lawrence C.
T1 - Research and its support under the National Mental Health Act.
JF - The American Journal of Psychiatry
JO - The American Journal of Psychiatry
JA - Am J Psychiatry
Y1 - 1994/06//
VL - 151
IS - 6, Suppl
SP - 210
EP - 215
CY - US
PB - American Psychiatric Assn
SN - 0002-953X
SN - 1535-7228
N1 - Accession Number: 1994-39525-001. Other Journal Title: American Journal of Insanity. Partial author list: First Author & Affiliation: Kolb, Lawrence C.; NIMH, US Public Health Service, Bethesda, MD, US. Release Date: 19941101. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Note: 105th Annual Meeting of the American Psychiatric Association (1949, Montreal, Canada). Major Descriptor: Experimentation; Government Agencies; Government Programs; History; Mental Disorders. Classification: History & Systems (2140). Population: Human (10). Page Count: 6. Issue Publication Date: Jun, 1994.
AB - Presented in 1949, this paper reports on a decade of planning and action to achieve the objectives of the National Mental Health Act (NMHA). In 1940, an advisory committee on nervous and mental diseases recommended federal support for a research institute, a recommendation endorsed by the Council of the American Psychiatric Association. While WWII caused the postponement of early plans, action was begun after the war, and the need for input from the social sciences was recognized at this time. Thus, the research program developed under the provisions of the NMHA has pursued 3 avenues: (1) the support of research projects across the US, (2) a research fellowship program, and (3) the construction of the National Institute of Mental Health. (0 ref) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - research supported by National Mental Health Act & creation of National Institute of Mental Health
KW - reprint of 1949 conference presentation
KW - 1994
KW - Experimentation
KW - Government Agencies
KW - Government Programs
KW - History
KW - Mental Disorders
KW - 1994
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1994-39525-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 104784004
T1 - Application of pulsed-field gel electrophoresis to the epidemiological characterization of Staphylococcus intermedius implicated in a food-related outbreak.
AU - Khambaty, F M
AU - Bennett, R W
AU - Shah, D B
Y1 - 1994/07//
N1 - Accession Number: 104784004. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - DNA -- Analysis
KW - Disease Outbreaks
KW - Electrophoresis, Gel, Pulsed-Field
KW - Staphylococcus -- Classification
KW - Butter -- Microbiology
KW - California
KW - DNA Fingerprinting
KW - Toxins
KW - Food Microbiology
KW - Margarine -- Microbiology
KW - Nevada
KW - Staphylococcus
KW - Staphylococcus -- Metabolism
SP - 75
EP - 81
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 113
IS - 1
PB - Cambridge University Press
AB - An outbreak of food intoxication involving over 265 cases in western United States occurred in October 1991. Staphylococcus intermedius was implicated as the aetiologic agent. Representative outbreak isolates (five clinical and ten from foods) produced type A enterotoxin. DNA fragments generated by four restriction endonucleases and analysed by pulsed-field gel electrophoresis (PFGE) provided definitive evidence that all isolates from nine different counties in California and Nevada were derived from a single strain. The PFGE pattern of these outbreak isolates was distinct from those of a heterogeneous collection of seven S. intermedius strains of veterinary origin and five unrelated S. aureus laboratory strains. The data show a significant PFGE pattern heterogeneity not only among members of different Staphylococcus species but also within members of the same species and even the same enterotoxin type. The results indicate that PFGE is a valuable strain-specific discriminator for the epidemiological characterization of S. intermedius. To our knowledge, this represents the first documented foodborne outbreak caused by S. intermedius. These findings suggest that the presence of S. intermedius and other species such as S. hyicus in food should be reason for concern.
SN - 0950-2688
AD - Division of Microbiological Studies, U.S. Food and Drug Administration, Washington, D.C. 20204.
U2 - PMID: 8062882.
DO - 10.1017/S0950268800051487
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104784004&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Price, A R
T1 - The 1993 ORI/AAAS conference on plagiarism and theft of ideas
JO - Journal of Information Ethics
JF - Journal of Information Ethics
Y1 - 1994///Fal
VL - 3
IS - 2
M3 - Article
SP - 54
EP - 63
SN - 10619321
AB - This article presents a review of a public conference on plagiarism and theft of ideas, sponsored by the Office of Research Integrity (ORI) and the American Association for the Advancement of Science (AAAS). The conference focused on philosophical and ethical issues, the historical context of plagiarism, detection, institutional and governmental experiences in handling plagiarism, the impact that the computer era has had on protecting words and ideas, misappropriation of ideas, and new activities in education and outreach that were undertaken by the ORI.
KW - ETHICS
KW - INTELLECTUAL property
KW - Research
KW - Science
N1 - Accession Number: ISTA3003428; Price, A R 1; Affiliations: 1 : U.S. Public Health Service, Rockville, MD; Source Info: Fal 1994, Vol. 3 Issue 2, p54; Note: Update Code: 3000; Subject Term: ETHICS; Subject Term: INTELLECTUAL property; Author-Supplied Keyword: Research; Author-Supplied Keyword: Science; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lih&AN=ISTA3003428&site=ehost-live&scope=site
DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 105850932
T1 - Intervention research in occupational health and safety.
AU - Goldenhar LM
AU - Schulte PA
Y1 - 1994/07//
N1 - Accession Number: 105850932. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807.
KW - Accidents, Occupational -- Prevention and Control
KW - Experimental Studies
KW - Occupational Health
KW - Safety
SP - 763
EP - 775
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
JA - J OCCUP MED
VL - 36
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0096-1736
AD - National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention, Cincinnati, OH 45226-1998.
U2 - PMID: 7931743.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850932&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107454532
T1 - Integrating PPIP into nursing curricula... Put Prevention Into Practice.
AU - Griffith H
Y1 - 1994/07//1994 Jul-Aug
N1 - Accession Number: 107454532. Language: English. Entry Date: 19941101. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - Education, Nursing
KW - Curriculum
KW - Preventive Health Care -- Education
SP - 200
EP - 200
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 10
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 8755-7223
AD - US Dept Health Human Services, Public Health Service Office Disease Prevention Health Promotion, Mary E Switzer Bldg, Rm 2132, 330 C St, SW, Washington DC 20201
U2 - PMID: 7930165.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107454532&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, Burt
AU - Goldsmith, Cynthia
AU - Johnson, Angela
AU - Padmalayam, Indira
AU - Baumstark, Barbara
T1 - Bacteriophage--like particle of Rochalimaea henselae.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1994/07//
VL - 13
IS - 1
M3 - Article
SP - 67
EP - 73
PB - Wiley-Blackwell
SN - 0950382X
AB - An extracellular particle approximately 40 nM in diameter was detected in culture supernatant from the fastidious bacterium Rochalimaea henselae . This particle has at least three associated proteins and contains 14 kbp linear DNA segments that are heterogeneous In sequence. The 14 kbp DNA was also present in R. henselae cells as an extrachromosomal element for all 14 strains tested. Despite attempts to induce lysis of R. henselae , plaque formation was not observed. A similar particle, also containing 14 kbp DNA, was observed in Bartonella bacilliformis , and may be analogous to a bacteriophage that has been described elsewhere for B. bacilliformis . [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteriophages
KW - Nucleic acids
KW - DNA
KW - Deoxyribose
KW - Bartonella
N1 - Accession Number: 16066971; Anderson, Burt 1,2; Goldsmith, Cynthia 1; Johnson, Angela 3; Padmalayam, Indira 3; Baumstark, Barbara 3; Affiliations: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA; 2: College of Medicine, MDC10, Department of Medical Microbiology and Immunology, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612-4799; 3: Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA; Issue Info: Jul1994, Vol. 13 Issue 1, p67; Thesaurus Term: Bacteriophages; Thesaurus Term: Nucleic acids; Subject Term: DNA; Subject Term: Deoxyribose; Subject Term: Bartonella; Number of Pages: 7p; Illustrations: 4 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107393707
T1 - Occupational hazards to male reproduction.
AU - Schrader SM
AU - Kanitz MH
Y1 - 1994/07//1994 Jul-Sep
N1 - Accession Number: 107393707. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Occupational Exposure
KW - Paternal Exposure
KW - Reproduction
KW - Occupational Health
KW - Abnormalities -- Epidemiology
KW - Reproduction -- Drug Effects
KW - Men's Health
KW - Male
SP - 405
EP - 414
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 9
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Since the field of reproductive toxicology was firmly established a generation ago, various approaches have been used to study toxicologic effects. The authors detail the reproductive effects that have been observed in a number of population-based studies, case-control studies, standardized fertility ratio studies, cohort studies, and clinical studies.
SN - 0885-114X
AD - Functional Toxicology Section, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Mail Stop C23, Cincinnati, OH 45226
U2 - PMID: 7831589.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107393707&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1995-21047-001
AN - 1995-21047-001
AU - Garrett, J. T.
AU - Garrett, Michael Walkingstick
T1 - The path of good medicine: Understanding and counseling Native American Indians.
T3 - Native American Indians
JF - Journal of Multicultural Counseling and Development
JO - Journal of Multicultural Counseling and Development
JA - J Multicult Couns Devel
Y1 - 1994/07//
VL - 22
IS - 3
SP - 134
EP - 144
CY - US
PB - American Counseling Assn
SN - 0883-8534
SN - 2161-1912
N1 - Accession Number: 1995-21047-001. Other Journal Title: Journal of Non-White Concerns in Personnel & Guidance. Partial author list: First Author & Affiliation: Garrett, J. T.; US Public Health Service, Indian Health Service, Health Care Administration/Contract Health Services, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 19950601. Correction Date: 20120116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Counseling; Cross Cultural Treatment; Culture (Anthropological); Values. Minor Descriptor: Aged (Attitudes Toward); Interpersonal Interaction; Religious Practices. Classification: Culture & Ethnology (2930). Population: Human (10). Page Count: 11. Issue Publication Date: Jul, 1994.
AB - Presents an overview of Native American cultural values, beliefs, and practices concerning the tribe, elders, family, and spirituality. Native American Indian communication style, humor, and cultural commitment are discussed, and recommendations for counseling with Native American Indians are given. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - overview of cultural values & beliefs & practices concerning tribe & elders & family & spirituality
KW - Native Americans
KW - implications for counseling
KW - 1994
KW - American Indians
KW - Counseling
KW - Cross Cultural Treatment
KW - Culture (Anthropological)
KW - Values
KW - Aged (Attitudes Toward)
KW - Interpersonal Interaction
KW - Religious Practices
KW - 1994
DO - 10.1002/j.2161-1912.1994.tb00459.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-21047-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1995-15083-001
AN - 1995-15083-001
AU - Steinweg, Kenneth K.
T1 - Retention rates and retention practices among graduates of Army Family Practice residency programs.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 1994/07//
VL - 159
IS - 7
SP - 516
EP - 519
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
N1 - Accession Number: 1995-15083-001. PMID: 7816225 Partial author list: First Author & Affiliation: Steinweg, Kenneth K.; Office of the Surgeon General, Clinical Policy & Consultants Div, Falls Church, VA, US. Release Date: 19950401. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Army Personnel; Family Physicians; Medical Education; Military Training; Occupational Tenure. Minor Descriptor: Military Medical Personnel. Classification: Professional Personnel Attitudes & Characteristics (3430); Military Psychology (3800). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 4. Issue Publication Date: Jul, 1994.
AB - Determined the career retention rate of 688 Army family practice residency graduates who graduated between 1973 and 1990. Ss' records were studied, and 8 characteristics of family practice graduates were examined for their effect on career retention. Significant predictors of retention were US Military Academy attendance, Uniform Services University of the Health Sciences attendance, fellowship training, and prior service. The 21.1% of Ss who had at least 1 of the 4 positive predictors formed two-thirds of the present career family physician force. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - career & training characteristics
KW - career retention rates
KW - Army family practice residency graduates
KW - 1994
KW - Army Personnel
KW - Family Physicians
KW - Medical Education
KW - Military Training
KW - Occupational Tenure
KW - Military Medical Personnel
KW - 1994
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-15083-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105850942
T1 - Cancer mortality patterns among female and male workers employed in a cable manufacturing plant during World War II.
AU - Ward EM
AU - Ruder AM
AU - Suruda A
AU - Smith AB
AU - Halperin W
AU - Fessler CA
AU - Zahm SH
Y1 - 1994/08//
N1 - Accession Number: 105850942. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807.
KW - Hydrocarbons -- Adverse Effects
KW - Neoplasms -- Mortality
KW - Occupational Diseases -- Mortality
KW - Occupational Exposure
KW - Acne Vulgaris -- Chemically Induced
KW - Adolescence
KW - Adult
KW - Aged
KW - Cause of Death
KW - Chlorine -- Adverse Effects
KW - Female
KW - Male
KW - Middle Age
KW - Neoplasms -- Chemically Induced
KW - New York
KW - Occupational Diseases
KW - Prospective Studies
KW - Retrospective Design
KW - War
KW - Women, Working
KW - Human
SP - 860
EP - 866
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
JA - J OCCUP MED
VL - 36
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0096-1736
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1988.
U2 - PMID: 7807266.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850942&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105850941
T1 - Cancer mortality in female and male dry-cleaning workers.
AU - Ruder AM
AU - Ward EM
AU - Brown DP
Y1 - 1994/08//
N1 - Accession Number: 105850941. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7502807.
KW - Bladder Neoplasms -- Mortality
KW - Industry
KW - Neoplasms -- Mortality
KW - Occupational Diseases -- Mortality
KW - Bladder Neoplasms -- Chemically Induced
KW - Cause of Death
KW - Esophageal Neoplasms -- Mortality
KW - Female
KW - Hydrocarbons, Chlorinated -- Adverse Effects
KW - Intestinal Neoplasms -- Mortality
KW - Male
KW - Neoplasms -- Chemically Induced
KW - Occupational Diseases
KW - Pancreatic Neoplasms -- Mortality
KW - Prospective Studies
KW - United States
KW - Women, Working
KW - Human
SP - 867
EP - 874
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
JA - J OCCUP MED
VL - 36
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0096-1736
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.
U2 - PMID: 7807267.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105850941&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107271574
T1 - Waiting for and receiving a liver transplant: 1988-1992... including commentary by Manzarbeitia C.
AU - Niemcryk SJ
AU - Bowen GS
AU - Marconi KM
AU - Aronoff R
AU - Braslow JB
Y1 - 1994/08//1994 Aug
N1 - Accession Number: 107271574. Language: English. Entry Date: 19980701. Revision Date: 20150818. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Liver Transplantation -- Trends -- United States
KW - Treatment Delay -- Adverse Effects -- United States
KW - Health Resource Allocation -- Trends -- United States
KW - Resource Databases
KW - Death
KW - Descriptive Statistics
KW - Logistic Regression
KW - Time Factors
KW - Risk Factors
KW - Chi Square Test
KW - United States
KW - Human
SP - 66
EP - 71
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 4
IS - 2
CY - Boulder, Colorado
PB - InnerDoorway Health Media
AB - The present study was designed to determine if the current allocation policy has had an adverse effect on national trends in orthotopic liver transplantation. Data collected by the United Network for Organ Sharing (UNOS) were examined for all individuals who were placed on the waiting list for a liver transplant or who received a liver transplant in the United States between January 1, 1988, and December 31, 1992. The rate of increase in the number of transplants conducted has slowed over the past 3 years. Over the same period, patient days on the waiting list have increased at a much faster rate. Mortality rates while waiting for a transplant, however, have shown a consistent annual decline from 1.17 deaths per 1,000 patient days in 1999 to 0.70 in 1992. The implications of the lengthening waiting list and the shortage of transplantable organs are discussed.
SN - 0905-9199
AD - Bureau of Health Resources Development, Health Resources and Services Administration, 5600 Fishers Lane (7A-07), Parklawn Building, Rockville, MD 20857
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271574&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Scribner, Curtis L.
AU - Kapit, Richard M.
AU - Phillips, Evelyne T.
AU - Rickles, Nathaniel M.
T1 - Aseptic Meningitis and Intravenous Immunoglobulin Therapy .
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1994/08/15/
VL - 121
IS - 4
M3 - Editorial
SP - 305
EP - 306
SN - 00034819
AB - Editorial. Deals with the association of aseptic meningitis syndrome with the use of intravenous immunoglobulin. Side effects reported with infusions of intravenous immunoglobulin; Information on U.S. Food and Drug Administration MEDWatch system; Indication for administration of intravenous immunoglobulin in the cases reported to MEDWatch.
KW - MENINGITIS
KW - IMMUNOGLOBULINS
N1 - Accession Number: 6977749; Scribner, Curtis L. 1; Kapit, Richard M. 1; Phillips, Evelyne T. 1; Rickles, Nathaniel M. 1; Source Information: 8/15/94, Vol. 121 Issue 4, p305; Subject: MENINGITIS; Subject: IMMUNOGLOBULINS; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1439
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Birthweight Differentials among Asian Americans.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/09//
VL - 84
IS - 9
M3 - Article
SP - 1444
EP - 1449
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examines differentials in mean birthweight and the risk for low birthweight among various Asian-American groups in New York State (n = 499 377). Methods. Using resident singleton live-birth records from New York State for 1985 and 1986, Asian-American births were compared with Black, American Indian, and White births. Multivariate ordinary least squares and logistic regression models were used to analyze ethnic differences. Results. Compared with White births, the expected mean difference in birthweight was -115 g for Chinese, -235 g for Japanese, -164 g for Filipinos, -120 g for Blacks, and 74 g for American Indians. The risk for low birthweight was 45% higher for Filipinos and 49% higher for Blacks as compared with Whites. Conclusions. Results of this study suggest substantial heterogeneity in mean birthweight and risk for low birthweight among ethnic groups in general and the major Asian-American groups in particular. Interestingly, after controlling for ethnic differences in sociodemographic risk factors, Filipinos appear to resemble Blacks much more closely than they do their Japanese and Chinese counterparts with respect to risk for low birthweight. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Birth weight
KW - Asian Americans
KW - Least squares
KW - Logistic regression analysis
KW - Filipinos
KW - Native Americans
KW - United States
N1 - Accession Number: 9410250729; Singh, Gopal K. 1; Yu, Stella M. 2; Affiliations: 1: National Center for Health Statistics, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville; 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; Issue Info: Sep94, Vol. 84 Issue 9, p1444; Subject Term: Birth weight; Subject Term: Asian Americans; Subject Term: Least squares; Subject Term: Logistic regression analysis; Subject Term: Filipinos; Subject Term: Native Americans; Subject: United States; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107410348
T1 - How to help your patients stop using tobacco.
AU - Meckleburg RE
Y1 - 1994///1994 Fall
N1 - Accession Number: 107410348. Language: English. Entry Date: 19950601. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials. Journal Subset: Allied Health; USA. NLM UID: 9816286.
KW - Smoking Cessation
KW - Dental Health Education
SP - 9
EP - 9
JO - Dental Hygienist News
JF - Dental Hygienist News
JA - DENT HYG NEWS
VL - 7
IS - 4
CY - Bloomfield Hills, Michigan
PB - Lally, McFarland, & Pantello
SN - 1082-9016
AD - National Cancer Institute, US Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107407231
T1 - The homecare worker: on the frontline of quality.
AU - Eustis NN
AU - Fischer LR
AU - Kane RA
Y1 - 1994///Fall94
N1 - Accession Number: 107407231. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9426452.
KW - Home Health Aides
KW - Professional-Patient Relations
KW - Quality Improvement
KW - Quality of Health Care
KW - Quality of Working Life
SP - 43
EP - 49
JO - Generations
JF - Generations
JA - GENERATIONS
VL - 18
IS - 3
CY - San Francisco, California
PB - American Society on Aging
SN - 0738-7806
AD - Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107407231&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107407233
T1 - Consumer choice and the frontline worker.
AU - Doty P
AU - Kasper J
AU - Litvak S
AU - Taylor H
Y1 - 1994///Fall94
N1 - Accession Number: 107407233. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9426452.
KW - Consumer Satisfaction
KW - Home Health Aides
KW - Home Health Agencies -- Legislation and Jurisprudence
KW - Decision Making, Patient
KW - Job Satisfaction
KW - Surveys
KW - Government Regulations
SP - 65
EP - 70
JO - Generations
JF - Generations
JA - GENERATIONS
VL - 18
IS - 3
CY - San Francisco, California
PB - American Society on Aging
SN - 0738-7806
AD - Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107407233&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107402386
T1 - The Medicaid program and the Clinton plan: implications for mental health services.
AU - Buck JA
AU - Koyanagi C
Y1 - 1994/09//1994 Sep
N1 - Accession Number: 107402386. Language: English. Entry Date: 19950401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0040250.
KW - Medicaid
KW - Mental Health Services
KW - Health Care Reform
SP - 883
EP - 887
JO - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JF - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JA - H&CP
VL - 45
IS - 9
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - This paper reviews problems that the Medicaid program poses for health care reformers and how the Clinton plan would deal with them. The Clinton plan represents a compromise between preserving or expanding the Medicaid program and eliminating it. The plan would seek to extend services to those without insurance and reduce health care costs, partly by limiting services and increasing out-of-pocket costs for Medicaid beneficiaries. All Medicaid beneficiaries would be included in the same basic system of health care that the plan proposes for other Americans. All current beneficiaries would remain eligible for Medicaid, but services would be reduced for many of them. However, services that are important for persons with severe mental illness would be maintained. The plan also would increase out-of-pocket costs for premiums and services, and these increases could be significant for some beneficiaries.
SN - 0022-1597
AD - Office of Policy and Planning at the Center for Mental Health Services, Rm 15-87, 5600 Fishers Lane, Rockville, Maryland 20857
U2 - PMID: 7989018.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107402386&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Aiken, Linda H.
AU - Salmon, Marla E.
AD - Center for Health Services & Policy Research, U PA
AD - US Public Health Service
T1 - Health Care Workforce Priorities: What Nursing Should Do Now
JO - Inquiry
JF - Inquiry
Y1 - 1994///Fall
VL - 31
IS - 3
SP - 318
EP - 329
SN - 00469580
N1 - Accession Number: 0349233; Keywords: Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 199505
KW - Health: General I10
KW - Professional Labor Markets; Occupational Licensing J44
L3 - http://www.inquiryjournalonline.org/loi/inqr
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UR - http://www.inquiryjournalonline.org/loi/inqr
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - ATTFIELD, MICHAEL D.
AU - HODOUS, THOMAS
T1 - Coal mining, emphysema, and compensation revisited.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 1994/09//
VL - 51
IS - 9
M3 - Article
SP - 647
EP - 647
SN - 13510711
N1 - Accession Number: 89974958; ATTFIELD, MICHAEL D. 1; HODOUS, THOMAS 2; Affiliations: 1: Epidemiology Section, Epidemiological Investigations Branch, Division of Respiratory Disease Studies; 2: Science and Policy Coordination Activity, Office, Director, Division of Safety Research, National Institute for Occupational Safety and Health-ALOSH, 944 Chestnut Ridge Road, Morgantown, WV 26505-2888, USA; Issue Info: Sep1994, Vol. 51 Issue 9, p647; Number of Pages: 2/5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1995-09777-001
AN - 1995-09777-001
AU - Bartholow, Bradford N.
AU - Doll, Lynda S.
AU - Joy, Dan
AU - Douglas, John M.
AU - Bolan, Gail
AU - Harrison, Janet S.
AU - Moss, Patricia M.
AU - McKirnan, David
T1 - Emotional, behavioral, and HIV risks associated with sexual abuse among adult homosexual and bisexual men.
JF - Child Abuse & Neglect
JO - Child Abuse & Neglect
JA - Child Abuse Negl
Y1 - 1994/09//
VL - 18
IS - 9
SP - 747
EP - 761
CY - Netherlands
PB - Elsevier Science
SN - 0145-2134
N1 - Accession Number: 1995-09777-001. PMID: 8000905 Partial author list: First Author & Affiliation: Bartholow, Bradford N.; US Dept of Health & Human Services, Public Health Service National Ctr for Infectious Diseases Ctrs for Disease Control & Prevention, Div of HIV/AIDS, Atlanta, GA, US. Release Date: 19950301. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bisexuality; Child Abuse; Male Homosexuality; Sexual Abuse. Minor Descriptor: Drug Usage; Emotional Adjustment; HIV; Human Males; Psychosexual Development; Risk Taking. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 15. Issue Publication Date: Sep, 1994.
AB - From May 1989 through April 1990, 1,001 adult homosexual and bisexual men (mean age 32.5 yrs) attending urban STD clinics were interviewed regarding abusive sexual contacts during childhood and adolescence. Child or adolescent sexual abuse (CASA) was significantly associated with mental health counseling and hospitalization, psychoactive substance use, depression, suicidal thoughts or actions, social support, sexual identity development, HIV risk behavior, and risk of STDs including HIV infection. Thus, CASA may have a wide-ranging influence on the quality of life and the health risk behavior of homosexual men. Increased awareness to the potential outcomes of male CASA is important to the design and implementation of medical and psychological services for sexually abused men. (Spanish abstract) (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child or adolescent sexual abuse
KW - emotional reactions & psychoactive drug use & sexual identity development & HIV risk behavior
KW - male homosexual or bisexual adults
KW - 1994
KW - Bisexuality
KW - Child Abuse
KW - Male Homosexuality
KW - Sexual Abuse
KW - Drug Usage
KW - Emotional Adjustment
KW - HIV
KW - Human Males
KW - Psychosexual Development
KW - Risk Taking
KW - 1994
DO - 10.1016/0145-2134(94)00042-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-09777-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107406289
T1 - Analysis of needlestick injuries to health care workers providing home care.
AU - Backinger CL
AU - Koustenis GH
Y1 - 1994/10//1994 Oct
N1 - Accession Number: 107406289. Language: English. Entry Date: 19950501. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Needlestick Injuries -- Epidemiology
KW - Organizational Policies
KW - Infection Control
KW - Home Health Care
KW - Stratified Random Sample
KW - Structured Questionnaires
KW - Surveys
KW - Kruskal-Wallis Test
KW - Descriptive Statistics
KW - Analysis of Variance
KW - Exploratory Research
KW - Home Health Agencies
KW - Human
SP - 300
EP - 306
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 22
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - Background: This research analyzed needlestick injuries sustained by employees working in the home health environment to determine to what extent existing infection control policies and procedures in home health care are effective in reducing the risk of transmission of blood-borne infections. Methods: In June and July 1992, a random sample of 600 directors of home health care agencies in the United States were sent questionnaires concerning written blood-borne infection control policies and procedures of home health care agencies. Agency characteristics were also identified. Results: A 46% response rate (n = 278) was obtained. Of the 226 agencies that reported needlestick injury rates, 102 agencies reported no needlestick injuries to home health care agency employees in the 'last year' and 124 agencies reported from one to 134 needlestick injuries, for a cumulative total of 475. Statistical analyses revealed that agencies with 'safer' sharps containers, 'safer' hypodermics, or 'safer' access to intravenous administration lines did not have statistically significantly rates of lower needlestick injury than agencies without these 'safer' products. Conclusions: This study should be considered exploratory; causal relationships cannot be established. Although written blood-borne infection control policies and procedures do not appear to provide protection to home health care workers from the risk of needlestick injury, limitations in the data exist. Consequently, results should be viewed with caution and additional research is needed.
SN - 0196-6553
AD - Center for Devices and Radiological Health, Food and Drug Administration, 5600 Fishers Lane, HFZ 510, Rockville, MD 20857
U2 - PMID: 7847637.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107406289&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107361508
T1 - Musculoskeletal disorders among visual display terminal users in a telecommunications company.
AU - Hales TR
AU - Sauter SL
AU - Peterson MR
AU - Fine LJ
AU - Putz-Anderson V
AU - Schleifer LR
AU - Ochs TT
AU - Bernard BP
Y1 - 1994/10//
N1 - Accession Number: 107361508. Language: English. Entry Date: 19960301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Job Diagnostic Survey (Hackman et al); Job Characteristics Inventory (Sims et al). NLM UID: 0373220.
KW - Computer Terminals
KW - Musculoskeletal Diseases -- Etiology
KW - Occupational Diseases -- Etiology
KW - Industry
KW - Occupational Health
KW - National Institute for Occupational Safety and Health
KW - Telecommunications
KW - Questionnaires
KW - T-Tests
KW - Analysis of Variance
KW - Chi Square Test
KW - Pearson's Correlation Coefficient
KW - Evaluation Research
KW - Descriptive Statistics
KW - Adult
KW - Middle Age
KW - Aged
KW - Human
SP - 1603
EP - 1621
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 37
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226
U2 - PMID: 7957018.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107361508&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107428008
T1 - Caregiving and women's Social Security benefits: a comment on Kingson and O'Grady-LeShane.
AU - Sandell SH
AU - Iams H
Y1 - 1994/10//
N1 - Accession Number: 107428008. Language: English. Entry Date: 19951101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0375327.
KW - Caregivers
KW - Economic and Social Security
KW - Women
KW - Income
KW - Retirement -- Economics
KW - United States
KW - Aged
KW - Female
SP - 680
EP - 684
JO - Gerontologist
JF - Gerontologist
JA - GERONTOLOGIST
VL - 34
IS - 5
PB - Oxford University Press / USA
SN - 0016-9013
AD - US Department of Health and Human Services, Rm 404E, 200 Independence Avenue SW, Washington, DC 20201
U2 - PMID: 7959137.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107428008&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107401082
T1 - Trends in the development of psychiatric services, 1844-1994.
AU - Thompson JW
Y1 - 1994/10//1994 Oct
N1 - Accession Number: 107401082. Language: English. Entry Date: 19950301. Revision Date: 20150711. Publication Type: Journal Article; historical material. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0040250.
KW - Mental Health Services -- Trends -- United States
KW - Attitude to Mental Illness -- History
KW - United States
KW - Economic Aspects of Illness
KW - Health Services Accessibility
KW - Psychiatric Care
KW - Social Environment
KW - Health Beliefs
KW - Health Facility Environment
KW - Stigma
KW - Community Mental Health Services -- Legislation and Jurisprudence
KW - Deinstitutionalization
KW - Social Attitudes
KW - Inpatients
KW - Outpatients
SP - 987
EP - 992
JO - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JF - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JA - H&CP
VL - 45
IS - 10
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Over the past 150 years, support for providing appropriate services for mentally ill persons has waxed and waned. In colonial America, mentally ill persons were institutionalized in jails or almshouses. In the 18th and 19th centuries, asylums constituted the primary psychiatric service. Only in the late 19th and early 20th centuries did alternatives to long-term hospitalization appear. The mental hygience movement of the early 20th century and the community mental health centers movement of the 1960s and 1970s both increased the number of services and introduced new types of services. Today, however, despite hopeful signs of reduced public prejudice against mentally ill persons, a new 'dark age' for support of psychiatric services may be dawning, as negative attitudes about mental illness continue to drive public policy.
SN - 0022-1597
AD - Center for Mental Health Services Research, University of Maryland School of Medicine, 645 West Redwood St, Baltimore, Maryland 21201
U2 - PMID: 7829054.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107401082&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107401095
T1 - Four decades of mental health trends: an empirical analysis of hospital and community psychiatry.
AU - Hennessy KD
AU - Greenberg RP
Y1 - 1994/10//1994 Oct
N1 - Accession Number: 107401095. Language: English. Entry Date: 19950301. Revision Date: 20150711. Publication Type: Journal Article; historical material; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0040250.
KW - Serial Publications -- Evaluation
KW - Mental Health Services -- Trends
KW - Writing for Publication -- Evaluation
KW - Historical Research
KW - Chi Square Test
KW - Sex Factors
KW - Comparative Studies
KW - Research
KW - Quantitative Studies -- Trends
KW - Empiricism
KW - Attitude of Health Personnel
KW - Program Evaluation
KW - Academic Achievement
KW - Inpatients
KW - Outpatients
KW - Male
KW - Female
KW - Human
SP - 1034
EP - 1039
JO - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JF - Hospital & Community Psychiatry: A Journal of the American Psychiatric Association
JA - H&CP
VL - 45
IS - 10
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Objective: The authors examined important trends and developments within the mental health field since the 1960s as relected in articles published in Hospital and Community Psychiatry. Methods: A total 798 articles were reviewed, representing all contributions to the journal in 1962, 1967, 1972, 1977, 1982, 1987, and 1992. Articles were classified into one of six categories, and empirical research articles were further classified by primary topic. In addition, all articles were indexed by primary setting (hospital, community, or both); academic credentials and gender of first author, and economic or public policy focus. Results: The number and percentage of empirical research articles increased over time, while articles describing programs and professional roles declined. Some changes were observed in the primary topics of empirical research. Other findings reflect a shift in the setting of articles from hospitals to the community and a growth in the percentage of women who were first authors and of authors with a Ph.D. degree. Conclusions: The documented growth of empirical research in psychiatry suggests a greater emphasis on methodological rigor in the design and implementation of mental health services. Moreover, increases noted in scholarly contributions by women and nonmedical professionals indicate a broadening of disciplinary perspective over time that is likely to strengthen psychiatric research and services.
SN - 0022-1597
AD - Office of Health Policy, Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Room 442-E, 200 Independence Ave SW, Washington, DC 20201
U2 - PMID: 7829042.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107401095&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107398678
T1 - Implementing the Put Prevention into Practice Program.
AU - Griffith HM
AU - Rahman MI
Y1 - 1994/10//1994 Oct
N1 - Accession Number: 107398678. Language: English. Entry Date: 19950201. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7603663.
KW - Government Programs
KW - Preventive Health Care
KW - Health Promotion
KW - Program Implementation
KW - Teaching Materials
KW - Program Evaluation
KW - Health Education
KW - Nurse Practitioners
KW - Health Services Accessibility
KW - Teamwork
SP - 12
EP - 19
JO - Nurse Practitioner
JF - Nurse Practitioner
JA - NURSE PRACT
VL - 19
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Put Prevention into Practice (PPIP) is a national program designed to improve the delivery of preventive care to patients by all primary care clinicians. It covers the full range of clinical preventive services, including immunizations, screening tests, chemoprophylaxis, and counseling interventions. The materials that comprise this program involve patients, office/clinic systems and staff, and clinicians, including nurse practitioners. The need for preventive care, the barriers to be overcome, the PPIP program, and a strategy for its implementation are delineated. Principles for successful implementation include: high level administrative support, ownership by all the players in the implementation process, a person designated to manage implementation, and an ongoing evaluation/auditing process that provides feedback to clinicians and others participating in the program.
SN - 0361-1817
AD - Office Disease Prevention Health Promotion US Public Health Service, Washington DC
U2 - PMID: 7816357.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107398678&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107393738
T1 - The role of respiratory protective devices in the control of tuberculosis.
AU - Hodous TK
AU - Coffey CC
Y1 - 1994/10//1994 Oct-Dec
N1 - Accession Number: 107393738. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Occupational Exposure -- Prevention and Control
KW - Respiratory Protective Devices
KW - Tuberculosis -- Prevention and Control
KW - Equipment and Supplies -- Standards
KW - Respiratory Protective Devices -- Standards
KW - Respiratory Protective Devices -- Trends
KW - Tuberculosis -- Transmission
KW - United States
KW - Ventilators, Mechanical -- Standards
SP - 631
EP - 657
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 9
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - In this comprehensive review, the authors describe various types of respirators and the major issues in their application to TB control, including the degree of protection they offer and cost. Recent recommendations regarding the use of respiratory protective devices also are discussed.
SN - 0885-114X
AD - Division of Safety Research, National Institute of Occupational Safety and Health, Morgantown, WV 26505
U2 - PMID: 7878492.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107393738&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Kodell, Ralph L.
AU - Chen, James J.
AU - Springer, Janet A.
AU - Lorentzen, Ronald J.
AU - Scheuplein, Robert J.
T1 - Point Estimates of Cancer Risk at Low Doses.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/10//
VL - 14
IS - 5
M3 - Article
SP - 843
EP - 851
SN - 02724332
AB - There has been considerable discussion regarding the conservativeness of low-dose cancer risk estimates based upon linear extrapolation from upper confidence limits. Various groups have expressed a need for best (point) estimates of cancer risk in order to improve risk/benefit decisions. Point estimates of carcinogenic potency obtained from maximum likelihood estimates of low-dose slope may be highly unstable, being sensitive both to the choice of the dose-response model and possibly to minimal perturbations of the data. For carcinogens that augment background carcinogenic processes and/or for mutagenic carcinogens, at low doses the tumor incidence versus target tissue dose is expected to be linear. Pharmacokinetic data may be needed to identify and adjust for exposure-dose nonlinearities. Based on the assumption that the dose response is linear over low doses, a stable point estimate for low-dose cancer risk is proposed. Since various models give similar estimates of risk down to levels of 1%, a stable estimate of the low-dose cancer slope is provided by ŝ = 0.01/ED01, where ED01 is the dose corresponding to an excess cancer risk of 1%. Thus, low-dose estimates of cancer risk are obtained by, risk = ŝ x dose. The proposed procedure is similar to one which has been utilized in the past by the Center for Food Safety and Applied Nutrition, Food and Drug Administration. The upper confidence limit, s*, corresponding to this point estimate of low-dose slope is similar to the upper limit, q1*, obtained from the generalized multistage model. The advantage of the proposed procedure is that g provides stable estimates of low-dose carcinogenic potency, which are not unduly influenced by small perturbations of the tumor incidence rates, unlike q̂1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Fix-point estimation
KW - Cancer -- Risk factors
KW - Pharmacokinetics
KW - Tumors
KW - Cancer risk
KW - Cancer risk, low-dose
KW - Conservativeness
KW - Dose-response curve, nonlinear
KW - Estimate, best
KW - Health risk assessment
KW - low-dose estimation
KW - point (best) estimates
N1 - Accession Number: 8114614; Gaylor, David W. 1; Kodell, Ralph L. 1; Chen, James J. 1; Springer, Janet A. 2; Lorentzen, Ronald J. 2; Scheuplein, Robert J. 2; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration; 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; Issue Info: Oct94, Vol. 14 Issue 5, p843; Thesaurus Term: Carcinogens; Subject Term: Fix-point estimation; Subject Term: Cancer -- Risk factors; Subject Term: Pharmacokinetics; Subject Term: Tumors; Author-Supplied Keyword: Cancer risk; Author-Supplied Keyword: Cancer risk, low-dose; Author-Supplied Keyword: Conservativeness; Author-Supplied Keyword: Dose-response curve, nonlinear; Author-Supplied Keyword: Estimate, best; Author-Supplied Keyword: Health risk assessment; Author-Supplied Keyword: low-dose estimation; Author-Supplied Keyword: point (best) estimates; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Behrens, Virginia
AU - Seligman, Paul
AU - Cameron, Lorraine
AU - Mathias, C. G. Toby
AU - Fine, Lawrence
T1 - The Prevalence of Back Pain, Hand Discomfort, and Dermatitis in the US Working Population.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1780
EP - 1780
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of the study was to provide the health care and public health communities with national prevalence estimates of selected conditions in the US working population. Methods. National prevalence estimates of self-reported conditions among working people were calculated from data collected for the 1988 Occupational Health Supplement to the National Health Interview Survey. Results. The highest prevalence estimates were found among occupational groups. For example, the prevalence of back pain due to an injury at work among truck drivers was 6.7%: back pain due to repeated activities at work among mechanics and repairers of heavy equipment and machinery was 10.5%; hand discomfort among operators of machines that process metal, plastic, stone, and glass was 23.5%; and dermatitis due to contact with substances at work among physicians, dentists, nurses, pharmacists, and dietitians was 5.6%. Conclusions. A substantial proportion of these conditions among occupational groups with the highest prevalence estimates are occupational in origin. These prevalence estimates identify occupations in which efforts are needed to prevent these conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Public health
KW - Backache
KW - Skin -- Inflammation
KW - Health surveys
N1 - Accession Number: 9411285523; Behrens, Virginia 1; Seligman, Paul 1; Cameron, Lorraine 1; Mathias, C. G. Toby 2; Fine, Lawrence 1; Affiliations: 1: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Group Health Associates, Cincinnati, Ohio; Issue Info: Nov94, Vol. 84 Issue 11, p1780; Thesaurus Term: Industrial hygiene; Thesaurus Term: Public health; Subject Term: Backache; Subject Term: Skin -- Inflammation; Subject Term: Health surveys; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Serdula, Mary K.
AU - Williamson, David F.
AU - Anda, Robert F.
AU - Levy, Alan
AU - Heaton, Alan
AU - Byers, Tim
T1 - Weight Control Practices in Adults: Result of a Multistate Telephone Survey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1821
EP - 1821
PB - American Public Health Association
SN - 00900036
AB - In this study, data collected in 1989 in a random-digit dialing telephone survey of 60 590 adults in 38 states and the District of Columbia were analyzed. Approximately 38% of women and 24% of men reported that they were currently trying to lose weight. Methods reported were counting calories (24% of women, 14% of Men), participating in organized weight loss programs (10%, 3%), taking special supplements (10%, 7%), taking diet pills (4%, 2%), and fasting for 24 hours or longer (5%, 5%). Among both sexes, only half of those trying to lose weight reported using the recommended method of caloric restriction combined with physical activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Weight loss
KW - Low-calorie diet
KW - Appetite depressants
KW - Fasting
KW - Telephone surveys
N1 - Accession Number: 9411285531; Serdula, Mary K. 1; Williamson, David F. 1; Anda, Robert F. 1; Levy, Alan 2; Heaton, Alan 2; Byers, Tim 1; Affiliations: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga.; 2: Division of Consumer Studies, Food and Drug Administration, Washington, DC; Issue Info: Nov94, Vol. 84 Issue 11, p1821; Thesaurus Term: Dietary supplements; Subject Term: Weight loss; Subject Term: Low-calorie diet; Subject Term: Appetite depressants; Subject Term: Fasting; Subject Term: Telephone surveys; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stuart, Charles A.
AU - Smith, Michele M.
AU - Gilkison, Charles R.
AU - Shaheb, Sudah
AU - Stahn, Ruggles M.
T1 - Acanthosis Nigricans among Native Americans: An Indicator of High Diabetes Risk.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1839
EP - 1839
PB - American Public Health Association
SN - 00900036
AB - Prevalence of the skin lesion acanthosis nigricans was determined in two tribal communities in Texas and Nebraska. Thirty-eight percent of the Alabama-Coushatta tribe of Texas had acanthosis nigricans. Nineteen percent of Omaha and Winnebago tribal children had the skin lesion, the youngest children had the least acanthosis nigricans. Among weight-matched Albama-Coushatta, fasting insulin concentration were twofold higher in subjects with the lesion. It was concluded that acanthosis nigricans is highly prevalent among Native Americans and that its presence suggests insulin resistance. Thus, it may identify those with the highest risk for non-insulin-dependent diabetes mellitus in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acanthosis nigricans
KW - Skin diseases
KW - Insulin resistance
KW - Diabetes
KW - Tribes
KW - Texas
KW - Nebraska
N1 - Accession Number: 9411285537; Stuart, Charles A. 1; Smith, Michele M. 2; Gilkison, Charles R. 1; Shaheb, Sudah 2; Stahn, Ruggles M.; Affiliations: 1: Department of Internal Medicine, University of Texas Medical Branch, Galveston; 2: Public Health Service Indian Health Service Hospital, Winnebago, Neb.; Issue Info: Nov94, Vol. 84 Issue 11, p1839; Subject Term: Acanthosis nigricans; Subject Term: Skin diseases; Subject Term: Insulin resistance; Subject Term: Diabetes; Subject Term: Tribes; Subject: Texas; Subject: Nebraska; Number of Pages: 4p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107337668
T1 - The allied health professions: two years of challenge and change... Third National Dental Hygiene Research Conference keynote address.
AU - Brand MK
Y1 - 1994/11//1994 Nov-Dec
N1 - Accession Number: 107337668. Language: English. Entry Date: 19970901. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8902616.
KW - Allied Health Professions -- Trends
KW - Education, Allied Health
KW - Health Services Accessibility -- Manpower
KW - Health Services Accessibility -- Economics
KW - Multiskilled Health Practitioners -- Education
KW - Research, Allied Health
KW - Curriculum Development
KW - Accreditation
KW - Government Programs
SP - 258
EP - 262
JO - Journal of Dental Hygiene
JF - Journal of Dental Hygiene
JA - J DENT HYG
VL - 68
IS - 6
CY - Chicago, Illinois
PB - American Dental Hygienists Association
SN - 1043-254X
AD - Bureau of Health Professions, United States Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107399440
T1 - A new tool for encouraging activity: Project PACE... Physician-based Assessment and Counseling for Exercise.
AU - Patrick K
AU - Sallis JF
AU - Long B
AU - Calfas KJ
AU - Wooten W
AU - Heath G
AU - Pratt M
Y1 - 1994/11//
N1 - Accession Number: 107399440. Language: English. Entry Date: 19950201. Revision Date: 20150820. Publication Type: Journal Article; forms; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0427461.
KW - Health Promotion
KW - Exertion
KW - Exercise
KW - Physician-Patient Relations
KW - Self Assessment
SP - 45
EP - 55
JO - Physician & Sportsmedicine
JF - Physician & Sportsmedicine
JA - PHYSICIAN SPORTSMED
VL - 22
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0091-3847
AD - Office Disease Prevention Health Promotion, US Public Health Service, Washington DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107399440&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2016-25750-001
AN - 2016-25750-001
AU - Patrick, Kevin
AU - Sallis, James F.
AU - Long, Barbara
AU - Calfas, Karen J.
AU - Wooten, Wilma
AU - Heath, Gregory
AU - Pratt, Michael
T1 - A new tool for encouraging activity.
JF - The Physician and Sports Medicine
JO - The Physician and Sports Medicine
Y1 - 1994/11//
VL - 22
IS - 11
SP - 45
EP - 55
CY - United Kingdom
PB - Taylor & Francis
SN - 0091-3847
AD - Patrick, Kevin, Department of Health and Human Services, Public Health Service, Office of the Assistant Secretary for Health, Switzer 2132, 330 C St SW, Washington, DC, US, 20201
N1 - Accession Number: 2016-25750-001. Partial author list: First Author & Affiliation: Patrick, Kevin; Office of Disease Prevention and Health Promotion, US Public Health Service, Washington, DC, US. Release Date: 20160623. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Exercise; Health Promotion; Physicians. Minor Descriptor: Physical Activity; Readiness to Change. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 11. Issue Publication Date: Nov, 1994.
AB - Promoting physical activity among patients is an essential role for physicians. Project PACE (Physician-based Assessment and Counseling for Exercise) is a practical system of matching physician counseling with patient readiness for physical activity. The PACE counseling approach will help physicians attain national goals for health promotion for the year 2000. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - physical activity
KW - Project PACE
KW - Physician-based Assessment and Counseling for Exercise
KW - readiness
KW - 1994
KW - Counseling
KW - Exercise
KW - Health Promotion
KW - Physicians
KW - Physical Activity
KW - Readiness to Change
KW - 1994
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107316036
T1 - Therapeutic-class wars -- drug promotion in a competitive marketplace.
AU - Kessler DA
AU - Rose JL
AU - Temple RJ
AU - Schapiro R
AU - Griffin JP
Y1 - 1994/11/17/
N1 - Accession Number: 107316036. Language: English. Entry Date: 19970301. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Drugs -- Economics -- United States
KW - Economic Competition -- United States
KW - Advertising -- United States
KW - United States
KW - Clinical Trials -- United States
SP - 1350
EP - 1353
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 331
IS - 20
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Food and Drug Administration, Department of Health and Human Services, Rockville, Md
U2 - PMID: 7935706.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Burke, L. B.;
T1 - Pharmacoeconomics before and after drug approval: regulatory perspective
CT - Pharmacoeconomics before and after drug approval: regulatory perspective
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1994/12/01/
VL - 29
IS - Dec
SP - PI
EP - 76
AD - Division of Drug Marketing, Advertising and Communications, Food and Drug Administration, 5600 Fishers Lane HFD-246, Rockville, MD 20857, USA
N1 - Accession Number: 31-12169; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics; Legislation, Laws and Regulations
N2 - The purpose of this presentation is to describe, from a regulatory viewpoint, the current interpretations and limitations of pharmaceutical cost-effectiveness and quality of life promotion by the industry. Current promotional activities can be evaluated in light of existing drug approval, labeling and advertising regulations and the strengths and limitations of various pharmacoeconomic study designs. FDA has progressed in the development of guidance and policies for comparative pharmacoeconomic claims as they are made by industry even as recent changes in both the pharmaceutical industry and the health care environment have altered the flow of information from industry to health care decision-makers. Minimal criteria for valid and reliable comparative drug studies are discussed with suggestions for making well-informed and appropriate drug use and formulary decisions. Learning objectives: 1. Name some common pitfalls in pharmacoeconomic study design and describe their relationship to the interpretation of comparative claims in drug promotion. 2. Discuss the interpretation of cost-effectiveness and quality of life claims in light of the currently available tools for measurement of such claims. 3. Describe the existing FDA regulations in light of their application to pharmacoeconomic promotion by the drug industry. Self-assessment questions: 1. A cost-effectiveness drug claim must be based on one or more adequate and well-controlled studies. 2. A quality of life claim must be measured with a validated quality of life instrument. 3. FDA regulations differentiate between efficacy and effectiveness. Answers: 1. True. 2. True. 3. False.
KW - ASHP meeting abstracts--pharmacoeconomics;
KW - Pharmacoeconomics--cost benefit analysis--drug approvals, FDA;
KW - Drugs--approvals--FDA, pharmacoeconomics;
KW - Food and Drug Administration (U.S.)--regulations--drug approvals, pharmacoeconomics;
KW - Regulations--Food and Drug Administration--drug approvals, pharmacoeconomics;
KW - Industry, pharmaceutical--regulations--drug approvals;
KW - Labeling--drugs--approvals, FDA regulations;
KW - Advertising--drugs--approvals, FDA regulations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107391460
T1 - Practical issues in the application of case management to substance abuse treatment.
AU - Ridgely MS
Y1 - 1994///1994 Winter
N1 - Accession Number: 107391460. Language: English. Entry Date: 19961201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Grant Information: Homeless Demonstration and Evaluation Branch of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). NLM UID: 9301156.
KW - Case Management
KW - Substance Abuse -- Therapy
KW - Funding Source
SP - 132
EP - 138
JO - Journal of Case Management
JF - Journal of Case Management
JA - J CASE MANAGE
VL - 3
IS - 4
CY - New York, New York
PB - Springer Publishing Company, Inc.
AB - Interest in case management has grown in the oubstance abuse treatment field because of changes in the way we think about substance abuse, problems in the current delivery of treatment, and pressures. In addition, subgroups of people have been identified who are unresponsive to currently available treatments or for whom special access problems are apparent. Case management is appealing because it involved accessing services and coordinating the care of individuals over long periods of time. This article briefly reviews the conduct of case management in substance abuse treatment by defining case management and discussing prevalent models, and then examining practical challenges faced in the implementation of case management.
SN - 1061-3706
AD - Center for Mental Health Services Research, University of Maryland School of Medicine, 10 S Pine Street, Suite 300, Baltimore, MD 21201
U2 - PMID: 7735083.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yao, Ruijin
AU - Burr, Don H.
AU - Doig, Peter
AU - Trust, Trevor J.
AU - Haiying Niu
AU - Guerry, Patricia
T1 - Isolation of motile and non-motile insertional mutants of Campylobacter jejuni: the role of motility in adherence and invasion of eukaryotic cells.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1994/12//
VL - 14
IS - 5
M3 - Article
SP - 883
EP - 893
PB - Wiley-Blackwell
SN - 0950382X
AB - A method of insertional mutagenesis for naturally transformable organisms has been adapted from Haemophilus influenzae and applied to the study of the pathogenesis of Campylobacter jejuni . A series of kanamycin-resistant insertional mutants of C. jejuni 81-176 has been generated and screened for loss of ability to invade INT407 cells. Eight non-invasive mutants were identified which showed 18-200-fold reductions in the level of invasion compared with the parent. Three of these eight show defects in motility, and five are fully motile. The three mutants with motility defects were further characterized to evaluate the method. One mutant, K2-32, which is non-adherent and non-invasive, has an insertion of the kanamycin-resistance cassette into the flaA flagellin gene and has greatly reduced motiilty and a truncated flagellar filament typical of flaA mutants. The adherent non-invasive mutants K2-37 and K2-55 are phenotypically paralysed, i.e, they have a full-length flagellar filament but are non-motile. All three mutants show an aberration in flagellar structure at the point at which the filament attaches to the cell. Mutants K2-37 and K2-55 represent overlapping deletions affecting the same gene, termed pflA (paralysed flagella). This gene encodes a predicted protein of 788 amino acid residues and a molecular weight of 90 977 with no significant homology to known proteins. Site-specific insertional mutants into this open reading frame result in the same paralysed flagellar phenotype and the same invasion defects as the original mutants. The differences in adherence between the two classes of flagellar mutant suggest that flagellin can serve as a secondary adhesion, although other adhesins mediate a motility-dependent internalization process. Characterization of the mutants at the molecular level and in animal models should further contribute to our understanding of the pathogenicity of these organisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter jejuni
KW - Microbial mutation
KW - Mobile genetic elements
KW - Motility of microorganisms
KW - Mutagenesis
N1 - Accession Number: 16002169; Yao, Ruijin 1; Burr, Don H. 1,2; Doig, Peter 3; Trust, Trevor J. 3; Haiying Niu 1; Guerry, Patricia 1; Affiliations: 1: Enteric Diseases Program, Naval Medical Research Institute Annex, 12300 Washington Avenue, Rockville, Maryland 20852, USA; 2: Food and Drug Administration, Washington, D.C., USA; 3: Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada; Issue Info: Dec1994, Vol. 14 Issue 5, p883; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: Microbial mutation; Thesaurus Term: Mobile genetic elements; Subject Term: Motility of microorganisms; Subject Term: Mutagenesis; Number of Pages: 11p; Illustrations: 6 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bailer, A. John
AU - Smith, Randall J.
T1 - Estimating Upper Confidence Limits for Extra Risk in Quantal Multistage Models.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/12//
VL - 14
IS - 6
M3 - Article
SP - 1001
EP - 1010
SN - 02724332
AB - Multistage models are frequently applied in carcinogenic risk assessment. In their simplest form, these models relate the probability of tumor presence to some measure of dose. These models are then used to project the excess risk of tumor occurrence at doses frequently well below the lowest experimental dose. Upper confidence limits on the excess risk associated with exposures at these doses are then determined. A likelihood-based method is commonly used to determine these limits. We compare this method to two computationally intensive "bootstrap" methods for determining the 95% upper confidence limit on extra risk. The coverage probabilities and bias of likelihood-based and bootstrap estimates are examined in a simulation study of carcinogenicity experiments. The coverage probabilities of the nonparametric bootstrap method fell below 95% more frequently and by wider margins than the better-performing parametric bootstrap and likelihood-based methods. The relative bias of all estimators are seen to be affected by the amount of curvature in the true underlying dose-response function. In general, the likelihood-based method has the best coverage probability properties while the parametric bootstrap is less biased and less variable than the likelihood-based method. Ultimately, neither method is entirely satisfactory for highly curved dose-response patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Cancer -- Risk factors
KW - Confidence intervals
KW - Estimation theory
KW - Probability theory
KW - Bootstrap method
KW - bootstrapping
KW - Carcinogen
KW - Dose-response
KW - Dose-response models
KW - Estimate bias
KW - likelihood-based confidence intervals
KW - Limit estimate, confidence, upper
KW - Risk assessment, cancer
N1 - Accession Number: 8114634; Bailer, A. John 1; Smith, Randall J. 1,2; Affiliations: 1: Department of Mathematics & Statistics, Miami University, Oxford, Ohio 45056; 2: Risk Assessment Program, Division of Standards Development and Technology Transfer, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226; Issue Info: Dec94, Vol. 14 Issue 6, p1001; Thesaurus Term: Risk assessment; Subject Term: Cancer -- Risk factors; Subject Term: Confidence intervals; Subject Term: Estimation theory; Subject Term: Probability theory; Author-Supplied Keyword: Bootstrap method; Author-Supplied Keyword: bootstrapping; Author-Supplied Keyword: Carcinogen; Author-Supplied Keyword: Dose-response; Author-Supplied Keyword: Dose-response models; Author-Supplied Keyword: Estimate bias; Author-Supplied Keyword: likelihood-based confidence intervals; Author-Supplied Keyword: Limit estimate, confidence, upper; Author-Supplied Keyword: Risk assessment, cancer; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Razzaghi, Mehdi
AU - Freni, Stan C.
AU - Moore, Gary E.
T1 - Reproducibility of the Dose-Response Curve of Steroid-Induced Cleft Palate in Mice.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/12//
VL - 14
IS - 6
M3 - Article
SP - 1073
EP - 1077
SN - 02724332
AB - Pregnant CD-1 mice were exposed to cortisone acetate at doses ranging from 20 to 100 mg/kg/ day on days 10-13 by oral and intramuscular routes. Multiple replicate assays were conducted under identical conditions to assess the reproducibility of the dose-response curve for cleft palate. The data were fitted to the probit, logistic, multistage or Armitage-Doll, and Weibull dose-response model separately for each route of exposure. The curves were then tested for parallel slopes (probit and logistic models) or coincidence of model parameters (multistage and Weibull models). The 19 replicate experiments had a wide range of slope estimates, wider for the oral than for the intramuscular experiments. For all models and both routes of exposure the null hypothesis of equality of slopes was rejected at a significant level of p < 0.001. For the intramuscular group of replicates, rejection of slope equality could in part be explained by not maintaining a standard dosing regime. The rejection of equivalence of dose-response curves from replicate studies showed that it is difficult to reproduce dose-response data of a single study within the limits defined by the dose-response model. This has important consequences for quantitative risk assessment, public health measures, or development of mechanistic theories which are typically based on a single animal bioassay. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dose-response relationship (Biochemistry)
KW - Steroids
KW - Risk assessment
KW - Cleft palate
KW - Mice as laboratory animals
KW - cleft palate
KW - Cortisone
KW - Dose-response curve
KW - Dose-response curves
KW - dose-response slopes
KW - Methodology
KW - replicate experiments
KW - Reproducibility
N1 - Accession Number: 8114640; Razzaghi, Mehdi 1; Freni, Stan C. 2; Moore, Gary E. 2; Affiliations: 1: Department of Mathematics and Computer Sciences, Bloomsburg University, Bloomsburg, Pennsylvania; 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Dec94, Vol. 14 Issue 6, p1073; Thesaurus Term: Dose-response relationship (Biochemistry); Thesaurus Term: Steroids; Thesaurus Term: Risk assessment; Subject Term: Cleft palate; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: cleft palate; Author-Supplied Keyword: Cortisone; Author-Supplied Keyword: Dose-response curve; Author-Supplied Keyword: Dose-response curves; Author-Supplied Keyword: dose-response slopes; Author-Supplied Keyword: Methodology; Author-Supplied Keyword: replicate experiments; Author-Supplied Keyword: Reproducibility; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Qi Zheng
T1 - On the Exact Hazard and Survival Functions of the MVK Stochastic Carcinogenesis Model.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1994/12//
VL - 14
IS - 6
M3 - Article
SP - 1081
EP - 1084
SN - 02724332
AB - The MVK two-stage carcinogenesis model is one of the most widely accepted mechanistic models in carcinogenesis modeling. However, due to a perceived difficulty in obtaining analytic solutions for the hazard and survival functions, approximations and numerical methods have been used to calculate these two fundamental quantities. This paper focuses on a special case of the homogeneous MVK model where the number of normal cells is constant. The probability generating function (pgf) for the number of tumor cells is derived, and the exact analytic solutions to the hazard and survival functions are obtained from the pgf. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Health risk assessment
KW - Biological models
KW - Cancer -- Risk factors
KW - Approximation theory
KW - birth-date-mutation model
KW - Cancer probability
KW - Carcinogenesis model, stochastic
KW - filtered Poisson process
KW - homogeneous MVK model
KW - Mathematical function, hazard and survival, exact
KW - Model, birth-death mutation
KW - Probability generating function
KW - tumor incidence rate
N1 - Accession Number: 8114639; Qi Zheng 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Dec94, Vol. 14 Issue 6, p1081; Thesaurus Term: Carcinogenesis; Thesaurus Term: Health risk assessment; Thesaurus Term: Biological models; Subject Term: Cancer -- Risk factors; Subject Term: Approximation theory; Author-Supplied Keyword: birth-date-mutation model; Author-Supplied Keyword: Cancer probability; Author-Supplied Keyword: Carcinogenesis model, stochastic; Author-Supplied Keyword: filtered Poisson process; Author-Supplied Keyword: homogeneous MVK model; Author-Supplied Keyword: Mathematical function, hazard and survival, exact; Author-Supplied Keyword: Model, birth-death mutation; Author-Supplied Keyword: Probability generating function; Author-Supplied Keyword: tumor incidence rate; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morrow-Howell, Nancy
T1 - The M word: Multicollinearity in multiple regression.
JO - Social Work Research
JF - Social Work Research
Y1 - 1994/12//
VL - 18
IS - 4
M3 - Article
SP - 247
EP - 251
PB - Oxford University Press / USA
SN - 10705309
AB - The article focuses on ways to deal with multicollinearity in multiple regression. Multicollinearity concerns only the relationships of the independent variables. Independent variables are highly correlated when information is redundant. although there may be a good reason for a researcher to collect redundant information, redundancy is not desirable in multiple regression. hen a correlation between independent variables is one, and there is perfect collinearity, the parameter cannot be calculated; perfect collinearity makes the necessary calculations mathematically impossible. Researchers could make this mistake if a categorical variable is converted to a series of dummy variables for inclusion in a regression model and all categories are retained in the model, or if a total score is computed from several subscores and the total and subscores are included in the same model. Large correlations do not prevent the inversion of the matrix, but the regression coefficients produced have two problems: inflated standard errors on the parameter estimates and reduced magnitude of the parameter estimates. It is always best to reduce the number of independent variables for conceptual reasons before multicollinearity problems arise in the calculations of the model estimates. The simplest solution is to omit the offending variable if only one correlation is the problem, which may be desirable if the researcher finds appeal in a simpler model. Another solution is to combine information from two variables into one. Rescaling the data has been suggested as a way to reduce multicollinearity. Especially in polynomial regression models, centering the original data can relieve multicollinearity problems. Two alternative solutions allow for retaining all the independent variables as they are. One approach is not to interpret the individual parameters at all but only use the model information, the R². Another solution is to use regression techniques other than least squares.
KW - MULTIPLE regression analysis
KW - REGRESSION analysis
KW - SOCIAL work research
KW - MATHEMATICAL statistics
KW - MATHEMATICAL models
N1 - Accession Number: 9607260352; Morrow-Howell, Nancy 1; Source Information: Dec94, Vol. 18 Issue 4, p247; Subject: MULTIPLE regression analysis; Subject: REGRESSION analysis; Subject: SOCIAL work research; Subject: MATHEMATICAL statistics; Subject: MATHEMATICAL models; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3544
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 1995-22500-001
AN - 1995-22500-001
AU - Gitlin, Michael J.
T1 - 'Lithium-induced renal dysfunction': Reply.
JF - Journal of Clinical Psychopharmacology
JO - Journal of Clinical Psychopharmacology
JA - J Clin Psychopharmacol
Y1 - 1994/12//
VL - 14
IS - 6
SP - 436
EP - 436
CY - US
PB - Lippincott Williams & Wilkins
SN - 0271-0749
SN - 1533-712X
N1 - Accession Number: 1995-22500-001. Partial author list: First Author & Affiliation: Gitlin, Michael J.; U California Medical Center, Adult Mental Health Services, Los Angeles, US. Release Date: 19950601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Kidney Diseases; Lithium; Psychiatric Patients; Side Effects (Drug). Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 1. Issue Publication Date: Dec, 1994.
AB - Replies to comments of R. H. Howland (see record [rid]1995-22507-001[/rid]) regarding evidence of lithium (Li)-induced renal insufficiency (RI) as originally presented by the author (M. J. Gitlin, 1993). Gitlin agrees that the 3 cases of RI found in bipolar patients who were taking maintenance Li discussed by Howland do not necessarily implicate Li as the etiologic agent. However, renal biopsy in 2 of these patients showed no other apparent cause of RI. It is suggested that a small, but not insignificant, number of bipolar patients treated with Li may show a decrease in renal function and that these changes should be looked for by periodic examinations. When creatinine levels rise toward and above 2.0 mg/100 ml, Li discontinuation should be considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - lithium
KW - development of renal insufficiency
KW - psychiatric patients
KW - commentary reply
KW - letter
KW - 1994
KW - Drug Therapy
KW - Kidney Diseases
KW - Lithium
KW - Psychiatric Patients
KW - Side Effects (Drug)
KW - 1994
DO - 10.1097/00004714-199412000-00019
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1998-00972-001
AN - 1998-00972-001
AU - Blumenthal, Susan J.
T1 - Guest editorial: Issues in women's mental health.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health
Y1 - 1994/12//
VL - 3
IS - 6
SP - 453
EP - 458
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1059-7115
N1 - Accession Number: 1998-00972-001. Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Blumenthal, Susan J.; Dept of Health & Human Services, Public Health Service, Office on Women's Health, Washington, DC, US. Release Date: 19980501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Epidemiology; Etiology; Government Policy Making; Human Sex Differences; Mental Disorders. Minor Descriptor: Treatment. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Page Count: 6. Issue Publication Date: Dec, 1994.
AB - Discusses the role of the Office on Women's Health within the US Public Health Service in supporting the recent focus on women's health issues, gender differences in the incidence and prevalence of mental disorders, biologic and psychosocial factors that contribute to these differences, gender differences in treatment, and possible causes of gender differences in the rates of mental illness. It is suggested that health care professionals must take thorough psychosocial histories, recognize gender differences in the etiology and course of mental disorders, and be sensitive to gender differences in treatment response to improve the care of women in clinical practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - federal support of women's health issues & gender differences in incidence & prevalence & treatment of mental disorders & possible causes
KW - 1994
KW - Epidemiology
KW - Etiology
KW - Government Policy Making
KW - Human Sex Differences
KW - Mental Disorders
KW - Treatment
KW - 1994
DO - 10.1089/jwh.1994.3.453
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1998-00972-003
AN - 1998-00972-003
AU - Blumenthal, Susan J.
T1 - Women and depression.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health
Y1 - 1994/12//
VL - 3
IS - 6
SP - 467
EP - 479
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1059-7115
N1 - Accession Number: 1998-00972-003. Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Blumenthal, Susan J.; Dept of Health & Human Services, US Public Health Service, Office on Women's Health, Washington, DC, US. Release Date: 19980501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Women's Mental Health: Issues for the 90s, 1993, San Francisco, US. Major Descriptor: Epidemiology; Human Sex Differences; Major Depression; Physiological Correlates; Psychosocial Factors. Minor Descriptor: Disease Course; Environment; Treatment; Trends. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Page Count: 13. Issue Publication Date: Dec, 1994.
AB - Investigates whether depression is really more prevalent in women, when do apparent gender differences in rates emerge, and what biological, psychosocial and environmental factors contribute to the gender differences in rates. A review of the scientific literature suggests that it is the interaction of a constellation of biological, social, economic, and emotional factors that helps explain the higher rates of depression found in women than in men. The nature of these factors is explored, and gender differences that arise in the clinical course of the illness and in response to treatment are discussed. Secular trends that suggest a narrowing of the gap in the incidence of depression between the genders are also discussed as well as possible reasons for these trends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex & rates of depression & biological & psychosocial & environmental factors & clinical course & treatment & trends in incidence of depression
KW - 1994
KW - Epidemiology
KW - Human Sex Differences
KW - Major Depression
KW - Physiological Correlates
KW - Psychosocial Factors
KW - Disease Course
KW - Environment
KW - Treatment
KW - Trends
KW - 1994
DO - 10.1089/jwh.1994.3.467
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Vanderveen, John E.
T1 - Regulatory history for stearic acid.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1994/12/02/Dec1994 Supplement
M3 - Article
SP - 983S
EP - 985S
SN - 00029165
AB - Before 1974 the only regulations involving stearic acid were for its use as a food additive. In 1974 the regulation for fat, fatty acid, and cholesterol contents was finalized; this regulation defined saturated fatty acid as the sum of lauric, myristic, palmitic, and stearic acids. Because the labeling of saturated fatty acid was voluntary except when a claim was made for fat content, the inclusion of stearic acid in that definition had little impact on foods high in fatty acids. Under the requirements of the Nutrition Labeling and Education Act (NLEA) of 1990, the definition of a saturated fatty acid gained major significance, with ties to mandatory nutrition labeling, nutrient content claims, and health claims. It was requested that stearic acid be dropped from the definition of a saturated fatty acid because it did not raise blood cholesterol concentrations. Scientific data demonstrating the lack of involvement of stearic acid consumption in negative health effects are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Food additives -- Law & legislation
KW - Stearic acid
KW - Saturated fatty acids
KW - Blood cholesterol
KW - Palmitic acid
KW - Nutrition -- Government policy
KW - NLEA
KW - Nutrition Labeling and Education Act
KW - saturated fatty acid
KW - Stearic acid
N1 - Accession Number: 94424878; Vanderveen, John E. 1; Affiliations: 1: Office of Plant and Dairy Foods and Beverages, US Food and Drug Administration, Washington, DC; Issue Info: Dec1994 Supplement, p983S; Thesaurus Term: RESEARCH; Thesaurus Term: Food additives -- Law & legislation; Subject Term: Stearic acid; Subject Term: Saturated fatty acids; Subject Term: Blood cholesterol; Subject Term: Palmitic acid; Subject Term: Nutrition -- Government policy; Author-Supplied Keyword: NLEA; Author-Supplied Keyword: Nutrition Labeling and Education Act; Author-Supplied Keyword: saturated fatty acid; Author-Supplied Keyword: Stearic acid; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107369517
T1 - Regulatory history for stearic acid... presented at Metabolic Consequences of Stearic Acid Relative to Other Long-Chain Fatty Acids.
AU - Vanderveen JE
Y1 - 1994/12/02/Dec1994 Supplement
N1 - Accession Number: 107369517. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; proceedings. Supplement Title: Dec1994 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Fatty Acids
KW - Food Labeling -- Legislation and Jurisprudence
KW - Dietary Fats
KW - Government Regulations -- History
KW - United States Food and Drug Administration
KW - United States
KW - Fatty Acids, Saturated -- Adverse Effects
SP - 983S
EP - 5S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
CY - Bethesda, Maryland
PB - American Society for Nutrition
SN - 0002-9165
AD - Office of Plant and Dairy Foods and Beverages, US Food and Drug Administration, 200 C Street SW, HFS-300, Washington, DC 20204
U2 - PMID: 7977156.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dzanis, David A.
T1 - The Association of American Feed Control Officials Dog and Cat Food Nutrient Profiles: Substantiation of Nutritional Adequacy of Complete and Balanced Pet Foods in the United.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1994/12/02/Dec94 Supplement
VL - 124
M3 - Article
SP - 2535S
EP - 2539S
SN - 00223166
AB - The Association of American Feed Control Official (AAFCO) formed the Canine (1990–1991) and Feline (1991–1992) Nutrition Expert Subcommittees to update the requirements for substantiation of ‘complete and balanced’ claims for pet foods sold in the United States. There are two means by which a company may substantiate nutritional adequacy for a dog or cat food. The first means is by formulating the food so that nutrient levels fall within the ranges as established in the AAFCO Dog and Cat Food Nutrient Profiles. These profiles replace the National Research Council recommendations as the recognized authority in the United States as that term is applied to AAFCO regulations. Levels of nutrients are based on practical formulations of pet foods with adjustments to account for bioavailability of nutrients in commonly used ingredients. Separate profiles for adult maintenance and growth and reproduction are set, and maximum levels of some nutrients are also established. The second means of substantiation is through the conduct of feeding trials following AAFCO protocols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animal nutrition
KW - Bioavailability
KW - FOOD
KW - Pets -- Feeding & feeds
KW - Food of animal origin
KW - Dogs
KW - Cats
KW - Nutrition research
KW - United States
KW - cats
KW - dogs
KW - nutrient profiles
KW - nutritional requirements
KW - symposium
KW - Association of American Feed Control Officials
N1 - Accession Number: 22583758; Dzanis, David A. 1; Affiliations: 1: Division of Animal Feeds, Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD 20855; Issue Info: Dec94 Supplement, Vol. 124, p2535S; Thesaurus Term: Animal nutrition; Thesaurus Term: Bioavailability; Thesaurus Term: FOOD; Subject Term: Pets -- Feeding & feeds; Subject Term: Food of animal origin; Subject Term: Dogs; Subject Term: Cats; Subject Term: Nutrition research; Subject: United States; Author-Supplied Keyword: cats; Author-Supplied Keyword: dogs; Author-Supplied Keyword: nutrient profiles; Author-Supplied Keyword: nutritional requirements; Author-Supplied Keyword: symposium ; Company/Entity: Association of American Feed Control Officials; NAICS/Industry Codes: 311111 Dog and Cat Food Manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 453910 Pet and Pet Supplies Stores; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107378220
T1 - The evolution of national nutrition policy.
AU - Kessler DA
Y1 - 1995/01//
N1 - Accession Number: 107378220. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 8209988.
KW - Nutrition
KW - Public Policy -- History
KW - United States
KW - Food Labeling
KW - United States Food and Drug Administration -- History
KW - Public Policy -- Trends
KW - Nutritional Requirements
KW - United States Department of Agriculture -- History
KW - United States Department of Agriculture -- Trends
KW - United States Food and Drug Administration -- Trends
SP - xiii
EP - xxvi
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
JA - ANNU REV NUTR
VL - 15
CY - Palo Alto, California
PB - Annual Reviews Inc.
AB - Domestic regulatory efforts in the area of nutrition historically have focused on achieving and sustaining the highest possible level of food safety and availability. More recently, the linkages between certain dietary practices and the risk of chronic, degenerative diseases have also become a significant focus of public policy. In order to promote good nutrition practices, the Food and Drug Administration (FDA) now requires a detailed and informative Nutrition Facts food label on virtually all food packages. Other public policies promoted by the FDA and others include increasing public knowledge of the relationship between diet and health; promoting unified food and nutrition policies among all government agencies; educating the American consumer about sound dietary practices; and encouraging the development of technologies that may result in more healthful, more abundant, and more affordable foods.
SN - 0199-9885
AD - Department of Health and Human Services, Food and Drug Administration, Rockville, Maryland, 20857
U2 - PMID: 8527212.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107378220&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hurrell Jr., Joseph J.
T1 - Police work, occupational stress and individual coping.
JO - Journal of Organizational Behavior
JF - Journal of Organizational Behavior
Y1 - 1995/01//
VL - 16
IS - 1
M3 - Article
SP - 27
EP - 28
SN - 08943796
AB - This article provides an impetus for a renewed research interest in occupational stress coping strategies in arguably high stress occupations such as policing. Moreover, the article breaks new ground by systematically considering the effects of both employee and spouse coping and by broadening the focus of interest in occupational stress coping to include largely overlooked stress coping strategies. Selecting employees on the basis of their ability to cope with organizational stressors or training them to better tolerate poorly designed organizations is a less desirable strategy than one that attempts to make the organization inherently less stressful. Indeed, altering the job or aspects of the organization as a means of reducing employee stress, represents a preferred approach because the focus is on changing the source of the problem (stressors), not the symptoms of stress. From a pragmatic standpoint, effective stress management interventions need to incorporate primary prevention strategies at the organizational level aimed at reducing or eliminating stressors at work. Ideally, occupational stress interventions should be comprehensive addressing the organizational environment, the individual and the individual-organizational interface.
KW - JOB stress
KW - POLICE
KW - EMPLOYEE training
KW - ADJUSTMENT (Psychology)
KW - INDIVIDUALISM
KW - STRESS management
KW - TOLERATION
N1 - Accession Number: 12496855; Hurrell Jr., Joseph J. 1; Affiliations: 1: National Institute for Occupational Safety and Health.; Issue Info: Jan1995, Vol. 16 Issue 1, p27; Thesaurus Term: JOB stress; Thesaurus Term: POLICE; Thesaurus Term: EMPLOYEE training; Subject Term: ADJUSTMENT (Psychology); Subject Term: INDIVIDUALISM; Subject Term: STRESS management; Subject Term: TOLERATION; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 912130 Provincial police services; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - CHAP
ID - 1995-98299-024
AN - 1995-98299-024
AU - Sauter, Steven L.
AU - Murphy, Lawrence R.
ED - Sauter, Steven L.
ED - Murphy, Lawrence R.
ED - Sauter, Steven L., (Ed)
ED - Murphy, Lawrence R., (Ed)
T1 - The changing face of work and stress.
T2 - Organizational risk factors for job stress.
Y1 - 1995///
SP - 1
EP - 6
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-297-X
N1 - Accession Number: 1995-98299-024. Partial author list: First Author & Affiliation: Sauter, Steven L.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 19960101. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-297-X, Paperback. Language: English. Major Descriptor: Occupational Stress; Risk Factors; Working Conditions. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 6.
AB - Provides an introduction to Organizational risk factors for job stress. In summary, recent years have witnessed unprecedented changes in the design and demands of work and shifting scientific paradigms for investigating the stresses imposed by the changing work environment. This volume provides a cross section of these developments in an effort to promote the understanding and control of risk factors for job stress and to thus protect the well-being of workers. The various sections and chapters included in this collection are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job stress
KW - risk factors
KW - work stressors
KW - changing work environment
KW - 1995
KW - Occupational Stress
KW - Risk Factors
KW - Working Conditions
KW - 1995
DO - 10.1037/10173-024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-98299-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1995-98912-004
AN - 1995-98912-004
AU - Fine, Theodora
ED - Pincus, Harold Alan
ED - Pincus, Harold Alan, (Ed)
T1 - Foundations and nonprofit research support.
T2 - Research funding and resource manual: Mental health and addictive disorders.
Y1 - 1995///
SP - 127
EP - 233
CY - Arlington, VA, US
PB - American Psychiatric Publishing, Inc.
SN - 0-89042-216-8
N1 - Accession Number: 1995-98912-004. Partial author list: First Author & Affiliation: Fine, Theodora; US Public Health Service, Office on Women's Health, Columbia, MD, US. Release Date: 19960401. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-89042-216-8, Hardcover. Language: English. Major Descriptor: Experimentation; Funding; Nonprofit Organizations. Minor Descriptor: Mental Health. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 107.
AB - offers some insights into the nature and structure of foundations, the extent of current support for mental health research, and the mechanisms available through which access to and funding by foundations may be achieved / provides information about the institutional profiles of foundations and other nonprofit institutions that offer varying levels of support for psychiatric researchers / [each profile contains information in the following areas: title, subject codes, other subject areas,] points of contact, address, foundation mission and description, and sample grants, if available (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nature & structure of foundations offering support for mental health research
KW - 1995
KW - Experimentation
KW - Funding
KW - Nonprofit Organizations
KW - Mental Health
KW - 1995
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-98912-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1995-99103-001
AN - 1995-99103-001
AU - Aral, Sevgi O.
AU - Wasserheit, Judith N.
ED - O'Leary, Ann
ED - Jemmott, Loretta Sweet
ED - O'Leary, Ann, (Ed)
ED - Jemmott, Loretta Sweet, (Ed)
T1 - Interactions among HIV, other sexually transmitted diseases, socioeconomic status, and poverty in women.
T2 - Women at risk: Issues in the primary prevention of AIDS.
T3 - AIDS prevention and mental health
Y1 - 1995///
SP - 13
EP - 41
CY - New York, NY, US
PB - Plenum Press
SN - 0-306-45041-0
N1 - Accession Number: 1995-99103-001. Partial author list: First Author & Affiliation: Aral, Sevgi O.; US Public Health Service, Dept of Health & Human Services, Rockville, MD, US. Release Date: 19960601. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-306-45041-0, Hardcover. Language: English. Major Descriptor: HIV; Human Females; Sexually Transmitted Diseases. Minor Descriptor: Human Sex Differences; Poverty; Psychosexual Behavior; Racial and Ethnic Differences; Socioeconomic Status. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 29.
AB - discuss the complex interrelationship between HIV infection and other STDs [sexually transmitted diseases in women]; the gender, race, and ethnicity differentials in STD rates; and the behavioral and societal determinants of these differentials [including SES and poverty] / an important factor that contributes to increasing levels of HIV infection among women is other STDs / [consider] needs in the area of STD/HIV research and policy and the implications for STD/HIV prevention programs (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - poverty & SES & other societal & behavioral determinants of gender & race & ethnicity differentials
KW - females with HIV & other sexually transmitted diseases
KW - 1995
KW - HIV
KW - Human Females
KW - Sexually Transmitted Diseases
KW - Human Sex Differences
KW - Poverty
KW - Psychosexual Behavior
KW - Racial and Ethnic Differences
KW - Socioeconomic Status
KW - 1995
DO - 10.1007/978-1-4899-1057-8_2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-99103-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1995-33266-001
AN - 1995-33266-001
AU - Wilson, Charlton
AU - Civic, David
AU - Glass, Daniel
T1 - Prevalence and correlates of depressive syndromes among adults visiting an Indian health service primary care clinic.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1995///
VL - 6
IS - 2
SP - 1
EP - 12
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1995-33266-001. PMID: 7734607 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Wilson, Charlton; United States Public Health Service, Mescalero Indian Hosp, NM, US. Release Date: 19950901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Epidemiology; Major Depression. Minor Descriptor: Clinics. Classification: Affective Disorders (3211). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 12. Issue Publication Date: 1995.
AB - Described the prevalence of depressive syndromes in an American Indian primary care clinic population and defined the clinical correlates of depressive syndromes in a clinic-based research study of depression undertaken by the Indian Health Service (IHS) in a southwestern US reservation clinic. 106 Ss from an IHS primary care clinic were systematically enlisted for participation in the study; all Ss completed the Inventory for Diagnosing Depression (IDD). 20.7% responded with answers scoring positive for a depressive syndrome; 8.9% of the Ss met IDD criteria for a major depressive syndrome. Age, sex, and other demographic information were not different between Ss with and without depression. A diagnosis of depression, a past history of depression, use of mental health facilities, unexplained pains, and antidepressant medication use were associated with the presence of a depressive syndrome. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence & clinical correlates of depressive syndrome
KW - American Indian adults seeking primary care from Indian Health Service on reservation
KW - 1995
KW - American Indians
KW - Epidemiology
KW - Major Depression
KW - Clinics
KW - 1995
DO - 10.5820/aian.0602.1995.1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1995-33266-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19598-003
AN - 2009-19598-003
AU - Murphy, Lawrence R.
T1 - Managing job stress: An employee assistance/human resource management partnership.
JF - Personnel Review
JO - Personnel Review
Y1 - 1995///
VL - 24
IS - 1
SP - 41
EP - 50
CY - United Kingdom
PB - Emerald Group Publishing Limited
SN - 0048-3486
SN - 1758-6933
N1 - Accession Number: 2009-19598-003. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Other Publishers: Emerald Publishing. Release Date: 20100531. Correction Date: 20170306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Stress Management; Human Resource Management. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: 1995. Copyright Statement: MCB University Press
AB - Over the past 20 years, there has been growing recognition of job stress as an important occupational health problem. This article describes the utility of an interdepartmental collaboration between employee assistance program and human resource management groups for managing job stress, and presents an example of such a collaboration in a US manufacturing firm. Starts from the premisses that stress at work is a significant and costly problem, and that the challenge for companies is to manage work stress in order to reduce health-care costs and improve productivity. Suggests that this challenge can be met by greater collaboration among company departments, bringing expertise from different areas to bear on the problem. Describes the conceptual basis for such collaboration and presents a case study of an ongoing partnership between an employee assistance program and a human resource management group. Ultimately, the most successful interventions will be those which meet the company goals of profitability and competitiveness, and the employee goals of job satisfaction, mental and physical health. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - employee assistance
KW - human resources management
KW - job stress management
KW - 1995
KW - Employee Assistance Programs
KW - Stress Management
KW - Human Resource Management
KW - 1995
DO - 10.1108/00483489510079075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19598-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1996-24256-001
AN - 1996-24256-001
AU - Nelson, Scott
T1 - 'An educational perspective of reservation mental health service deficit: The South Dakota experience': Commentary.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 1995///
VL - 6
IS - 3
SP - 68
EP - 70
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
N1 - Accession Number: 1996-24256-001. Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Nelson, Scott; Indian Health Service, Social Services Branch, Office of Mental Health Programs, Albuquerque, NM, US. Release Date: 19960801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: American Indians; Job Satisfaction; Mental Health Personnel; Professional Development; Working Conditions. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Page Count: 3. Issue Publication Date: 1995.
AB - Comments on the article by V. S. Bhatara et al (see record [rid]1996-24284-001[/rid]) focusing on the issues related to the training and retention of American Indian mental health and social service professionals. New ways for enhancing the professional training of American Indian persons are being explored, particularly for those living in remote geographic areas. Several universities have developed relationships with service sites and tribes for trainee clinical experiences in an American Indian country. To be effective, strategies for recruiting and retaining behavioral health professionals should be site-, individual-, and group-specific, as well as cost-effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - income & work & community conditions & peer interaction & continuing education opportunities
KW - job satisfaction & turnover
KW - mental health professionals on Indian reservations
KW - commentary
KW - 1995
KW - American Indians
KW - Job Satisfaction
KW - Mental Health Personnel
KW - Professional Development
KW - Working Conditions
KW - 1995
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
T1 - Drug Disorders and Cardiovascular Disease: The Impact on Annual Hospital Length of Stay for the Medicare Population.
AU - Ingster, Lillian M.
AU - Cartwright, William S.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1995/02//
VL - 21
IS - 1
SP - 93
EP - 110
SN - 00952990
N1 - Accession Number: 9505022970; Author: Ingster, Lillian M.: 1 Author: Cartwright, William S.: 2 ; Author Affiliation: 1 National Center for Health Statistics 6525 Belcrest Hd., Hyattsville, Maryland 20782.: 2 Information Services & Analysis Branch Division of State Programs Center for Substance Abuse Treatment 5600 Fishers Lane-Rockwall II Bfdg., Rockville, Maryland.; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20050912
N2 - We studied 3,942,868 Medicare patients (comprised of elderly and disabled) discharged with cardiovascular disease (CVD) during 1987, of which 41,095 (1%) had a drug disorder. Among this small subgroup, the percent of those overlapping with an alcohol and/or mental disorder is 33% for the elderly and 47% for the disabled. The presence of a drug disorder discharge diagnosis is associated with an excess of 329,650 days of hospital care and $174,498,071 in hospital charges as illustrated by a 51% increase in average annual days in the hospital for the elderly, and a similar 61% increase for the disabled. The concomitant increase in average annual discharges offers an explanation. Clinical progression in drug disorder severity (six categories were defined) is associated with increasing lengths of stay; for example, drug dependence comorbidities present longer lengths of stay than drug abuse comorbidities. Among the 12 categories of CVD defined, patients with rheumatic heart disease, hypertensive heart disease, hypertension, and other venous disorders were chose whose length of stay experienced the largest percent increase when a drug disorder was present. When drug disorders compete with alcohol and/or mental disorders in a general linear model predicting average annual length of stay, they remain significant at the p < .001 level. ABSTRACT FROM AUTHOR
KW - *CARDIOVASCULAR diseases
KW - *CARDIOVASCULAR system
KW - *HEALTH insurance
KW - LENGTH of stay in hospitals
KW - MEDICARE
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107394658
T1 - Nursing home residents at risk of hospitalization and the characteristics of their hospital stays.
AU - Murtaugh CM
AU - Freiman MP
Y1 - 1995/02//
N1 - Accession Number: 107394658. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0375327.
KW - Nursing Home Patients
KW - Transfer, Discharge -- In Old Age
KW - Aged, Hospitalized
KW - Databases
KW - Purposive Sample
KW - Mathematics
KW - Cox Proportional Hazards Model
KW - Descriptive Statistics
KW - Multivariate Analysis
KW - Outcomes (Health Care)
KW - Aged
KW - Inpatients
KW - Male
KW - Female
KW - Human
SP - 35
EP - 43
JO - Gerontologist
JF - Gerontologist
JA - GERONTOLOGIST
VL - 35
IS - 1
PB - Oxford University Press / USA
SN - 0016-9013
AD - Agency for Health Care Policy and Research, US Department of Health and Human Services, Suite 500, 2101 East Jefferson Street, Rockville, MD 20852
U2 - PMID: 7890201.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107394658&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Claunts, Frank P.
T1 - FEDERAL AGENCY COMPLIES WITH ACT.
JO - Journal of Accountancy
JF - Journal of Accountancy
Y1 - 1995/02//
VL - 179
IS - 2
M3 - Letter
SP - 10
EP - 11
PB - American Institute of Ceritified Public Accountants
SN - 00218448
AB - A letter to the editor is presented in response to the article "Federal Agencies Don't Comply With CFO Act," in the August 1, 1994 issue.
KW - GOVERNMENT agencies
KW - LETTERS to the editor
N1 - Accession Number: 17514522; Claunts, Frank P. 1; Affiliations: 1: Director, Office of Financial Management, Food and Drug Administration, Rockville, Maryland; Issue Info: Feb1995, Vol. 179 Issue 2, p10; Thesaurus Term: GOVERNMENT agencies; Subject Term: LETTERS to the editor; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Murthy, Leela I.
AU - Halperin, William E.
T1 - Medical Screening and Biological Monitoring.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/02//
VL - 37
IS - 2
M3 - Article
SP - 170
EP - 184
SN - 00961736
AB - The use of medical screening and biological monitoring has seen substantial changes in the past two decades specifically in the provision of occupational medical services. For example, national surveys of workplaces conducted by the National Institute for Occupational Safety and Health (NIOSH) showed that the provision of off-site medical care to workers increased from 19.6% in 1972-1974 to 57.8% in 1981- 1983, although the percent of workers receiving on-site services remained stable during the same period. After a recent survey in 1990—1991, the Occupational Safety and Health Administration (OSHA) estimated that 6.3% of US industries have a medical surveillance program at their individual establishment. We reviewed NIOSH documents, OSHA's Code of Federal Regulations, and texts on biological monitoring and medical screening for recommendations on medical surveillance of workers. This report summarizes the medical tests (including biologic monitoring) recommended or used by independent investigators and by the government for OSHA-regulated substances to provide guidance to physicians and occupational health professionals in accessing the pertinent literature; the utility of the recommendations is not evaluated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113380016; Murthy, Leela I. 1; Halperin, William E. 1; Source Information: Feb1995, Vol. 37 Issue 2, p170; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rivo, Marc L.
AU - Henderson, Tim M.
AU - Jackson, Debbie M.
T1 - State Legislative Strategies to Improve the Supply and Distribution of Generalist Physicians, 1985 to 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/03//
VL - 85
IS - 3
M3 - Article
SP - 405
EP - 407
PB - American Public Health Association
SN - 00900036
AB - State laws enacted between 1985 and 1992 were reviewed to examine state involvement in influencing the supply and distribution of generalist physicians. Forty-seven states enacted 238 relevant laws during this period. In 1991 and 1992, 36 states enacted 98 laws, as compared with 1985 and 1986, when 8 states enacted 12 laws. Legislation addressed planning and oversight; financial incentives to institutions, students, and residents; and strategies to enhance the practice environment. A new strategy is to link funding to measurable outcomes, such as the career choices of a state medical school's graduates. Few states devoted resources to evaluate their efforts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - State laws
KW - Physicians
KW - Labor supply
KW - Labor laws & legislation
KW - Medical laws & legislation
KW - Incentives in industry
N1 - Accession Number: 9504040213; Rivo, Marc L. 1; Henderson, Tim M. 2; Jackson, Debbie M. 1; Affiliations: 1: Division of Medicine, Bureau of Health Professions, Health Resources and Services Administration, Rockville, Md.; 2: Intergovernmental Health Policy Project, George Washington University, Washington, DC.; Issue Info: Mar1995, Vol. 85 Issue 3, p405; Subject Term: State laws; Subject Term: Physicians; Subject Term: Labor supply; Subject Term: Labor laws & legislation; Subject Term: Medical laws & legislation; Subject Term: Incentives in industry; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Molzon, J. A.;
AU - Pisano, D. J.;
T1 - STATUS OF PHARMACY LAW INSTRUCTION IN U.S. PHARMACY SCHOOLS: ADDENDUM
CT - STATUS OF PHARMACY LAW INSTRUCTION IN U.S. PHARMACY SCHOOLS: ADDENDUM
JO - APhA Annual Meeting
JF - APhA Annual Meeting
Y1 - 1995/03/01/
VL - 142
IS - Mar
SP - 119
AD - U.S. Public Health Service
N1 - Accession Number: 32-14507; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmaceutical Education; Legislation, Laws and Regulations
N2 - This discussion is an addendum to ongoing studies regarding the status of pharmacy law instruction in United States schools and colleges of pharmacy. The 1993 report detailed topics covered, references used, instructor, credentialing and curricular positioning. Since that time, an additional survey was conducted in order to develop a comprehensive list of instructors, degrees held and teaching experience.
KW - Laws--pharmacy--pharmaceutical education;
KW - Pharmacy--laws--pharmaceutical education;
KW - Education, pharmaceutical--curriculum--pharmacy laws;
KW - Curriculum--education, pharmaceutical--pharmacy laws;
KW - APhA meeting abstracts--pharmacy laws;
KW - United States--education, pharmaceutical--pharmacy laws;
KW - Schools--pharmacy--law curriculum;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107189870
T1 - Heart failure: evaluation and care of patients with left ventricular systolic dysfunction.
AU - Konstam MA
AU - Dracup K
AU - Baker DW
AU - Bottorff MB
AU - Brooks NH
AU - Dacey RA
AU - Dunbar SB
AU - Jackson AB
AU - Jessup M
AU - Johnson JC
AU - Jones RH
AU - Luchi RJ
AU - Massie BM
AU - Pitt B
AU - Rose EA
AU - Rubin LJ
AU - Wright RF
AU - Hadorn DC
Y1 - 1995/03//1995 Mar
N1 - Accession Number: 107189870. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; practice guidelines. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442138.
KW - Heart Failure -- Diagnosis
KW - Heart Failure -- Therapy
SP - 183
EP - 187
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
JA - J CARD FAIL
VL - 1
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 1071-9164
AD - Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, Washington, DC
U2 - PMID: 9420649.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104791259
T1 - Public policy issues: an American perspective.
AU - Lee, P R
Y1 - 1995/03//
N1 - Accession Number: 104791259. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879.
KW - Health Care Reform -- Economics
KW - Health Care Costs
KW - Health Policy
KW - Insurance, Health
KW - Socioeconomic Factors
KW - United States
SP - 4
EP - 16
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
JA - J R SOC MED
VL - 88
IS - 3
PB - Sage Publications, Ltd.
SN - 0141-0768
AD - US Public Health Service, Department of Health & Human Services, Washington DC, USA.
U2 - PMID: 8815242.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2013-13240-016
AN - 2013-13240-016
AU - Carey, Martha Ann
T1 - The continuing need for research on vocational rehabilitation programs.
T3 - Making Work a Priority
JF - Psychosocial Rehabilitation Journal
JO - Psychosocial Rehabilitation Journal
Y1 - 1995///Spr 1995
VL - 18
IS - 4
SP - 163
EP - 164
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University
SN - 0147-5622
N1 - Accession Number: 2013-13240-016. Other Journal Title: Psychiatric Rehabilitation Journal. Partial author list: First Author & Affiliation: Carey, Martha Ann; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, US Public Health Services, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University. Release Date: 20130429. Correction Date: 20151026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health Service Needs; Policy Making; Program Development; Vocational Rehabilitation. Minor Descriptor: Mental Disorders; Quality of Life. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10). Page Count: 2. Issue Publication Date: Spr 1995.
AB - Examination and documentation of effective vocational rehabilitation programs are essential to the best use of resources, and, therefore, are needed for policy development and program planning. With resources becoming more limited, there is an increasing need for information on what works best, for whom, under what conditions, why, and how much it costs. A major leadership role provided by the federal government is support for the development of such information through demonstration programs and, increasingly, includes dissemination of research results. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vocational rehabilitation programs
KW - policy development
KW - program planning
KW - quality of life
KW - mental illness
KW - needs
KW - research
KW - 1995
KW - Experimentation
KW - Health Service Needs
KW - Policy Making
KW - Program Development
KW - Vocational Rehabilitation
KW - Mental Disorders
KW - Quality of Life
KW - 1995
DO - 10.1037/h0095472
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Yetley, Elizabeth A.
AU - Park, Youngmee K.
T1 - Diet and Heart Disease: Health Claims.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1995/03/02/Mar95 Supplement
VL - 125
M3 - Article
SP - 679S
EP - 685S
SN - 00223166
AB - The Nutrition Labeling and Education Act of 1990 states, in part, that a product is misbranded if it bears a claim that characterizes the relationship of a nutrient to a disease or health-related condition (health claim), unless the claim is made in accordance with Food and Drug Administration (FDA) regulations. In response to the new law, on January 6, 1993, the FDA promulgated regulations that described general requirements for health claims on foods in conventional food forms and specific requirements for seven authorized health claim topics. Three authorized claims are related to heart disease: dietary saturated fat and cholesterol and coronary heart disease; fruits, vegetables and grain products that contain fiber, particularly soluble fiber, and risk of coronary heart disease and sodium and hypertension. The general requirements regulation specifies the scientific standard for assessing the validity of claims, criteria for the qualification of claims, conditions for disqualification and general labeling requirements for health claims. Approval for health claims is based on the totality of publicly available scientific evidence and significant agreement among experts qualified by scientific training and experience to evaluate the relationship. On January 4, 1994, the FDA finalized similar requirements for health claims on dietary supplements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diet therapy
KW - Elemental diet
KW - Diet in disease
KW - Coronary heart disease
KW - Heart diseases
KW - Hypertension
KW - Sodium -- Physiological effect
KW - Blood lipids
KW - Lipid metabolism disorders
KW - Food -- Fiber content
KW - Fiber in human nutrition
KW - diet and health
KW - fiber-rich foods and coronary heart disease
KW - health claim
KW - lipids and coronary heart disease
KW - sodium and hypertension
N1 - Accession Number: 22569260; Yetley, Elizabeth A. 1; Park, Youngmee K. 1; Affiliations: 1: Food and Drug Administration, U.S. Department of Health and Human Services, Washington, DC 20204; Issue Info: Mar95 Supplement, Vol. 125, p679S; Subject Term: Diet therapy; Subject Term: Elemental diet; Subject Term: Diet in disease; Subject Term: Coronary heart disease; Subject Term: Heart diseases; Subject Term: Hypertension; Subject Term: Sodium -- Physiological effect; Subject Term: Blood lipids; Subject Term: Lipid metabolism disorders; Subject Term: Food -- Fiber content; Subject Term: Fiber in human nutrition; Author-Supplied Keyword: diet and health; Author-Supplied Keyword: fiber-rich foods and coronary heart disease; Author-Supplied Keyword: health claim; Author-Supplied Keyword: lipids and coronary heart disease; Author-Supplied Keyword: sodium and hypertension; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Lee, Philip R.
AU - Stewart, Felicia H.
T1 - Editorial: Failing to Prevent Unintended Pregnancy Is Costly.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Editorial
SP - 479
EP - 480
PB - American Public Health Association
SN - 00900036
AB - The article discusses issues concerning the failure to prevent unintended pregnancy. In the U.S., more than half of all pregnancies are unintended. It addresses the significance of contraception in the prevention of unwanted pregnancy. Moreover, some of the cost-effective contraceptives mentioned include oral, injectable, and implanted hormonal contraceptives and intrauterine devices. Another way to prevent pregnancy is the utilization of emergency contraceptive pill treatment after unprotected intercourse.
KW - Cost effectiveness
KW - Unwanted pregnancy
KW - Contraceptives
KW - Oral contraceptives
KW - Intrauterine contraceptives
KW - Sexual intercourse
KW - United States
N1 - Accession Number: 20700159; Lee, Philip R. 1; Stewart, Felicia H. 2; Affiliations: 1: Public Health Service, US Department of Health and Human Services, Washington, DC.; 2: Office of Population Affairs, Public Health Service, US Department of Health and Human Services, Bethesda, Md.; Issue Info: Apr95, Vol. 85 Issue 4, p479; Thesaurus Term: Cost effectiveness; Subject Term: Unwanted pregnancy; Subject Term: Contraceptives; Subject Term: Oral contraceptives; Subject Term: Intrauterine contraceptives; Subject Term: Sexual intercourse; Subject: United States; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trussel, James
AU - Leveque, Joseph A.
AU - Koenig, Jacqueline D.
AU - London, Robert
AU - Borden, Spencer
AU - Henneberry, Joan
AU - LaGuardia, Katherine
AU - Stewart, Felicia
AU - Wilson, T. George
AU - Wysocki, Susan
AU - Strauss, Michael
T1 - The Economic Value of Contraception: A Comparison of 15 Methods.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Article
SP - 494
EP - 503
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of the study was to determine the clinical and economic impact of alternative contraceptive methods. Methods. Direct medical costs (method use, side effects, and unintended pregnancies) associated with 15 contraceptive methods were modeled from the perspectives of a private payer and a publicly funded program. Cost data were drawn from a national claims database and Medical. The main outcome measures included 1-year and 5-year costs and number of pregnancies avoided compared with use of no contraceptive method. Results. All 15 contraceptives were more effective and less costly than no method. Over 5 years, the copper-T IUD, vasectomy, the contraceptive implant, and the injectable contraceptive were the most cost-effective, saving $14 122, $13 899, $13 813, and $13 373, respectively, and preventing approximately the same number of pregnancies (4.2) per person. Because of their high failure rates, barrier methods, spermieides, withdrawal, and periodic abstinence were costly but still saved from $8933 to $12 239 over 5 years. Oral contraceptives fell between these groups, costing $1784 over 5 years, saving $12 879, and preventing 4.1 pregnancies. Conclusions. Contraceptives save health care resources by preventing unintended pregnancies. Up-front acquisition costs are inaccurate predictors of the total economic costs of competing contraceptive methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Contraceptives
KW - Medical care costs
KW - Databases
KW - Pregnancy
KW - Vasectomy
KW - Injectable contraceptives
N1 - Accession Number: 9504260426; Trussel, James 1,2; Email Address: trussel@princeton.edu; Leveque, Joseph A. 3; Koenig, Jacqueline D. 3; London, Robert 4; Borden, Spencer 5; Henneberry, Joan 6; LaGuardia, Katherine 7; Stewart, Felicia 8; Wilson, T. George 9; Wysocki, Susan 10; Strauss, Michael 3; Affiliations: 1: Office of Population Research, Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ.; 2: Department of Economics, Princeton University, Princeton, NJ.; 3: Health Technology Associates, Washington, DC.; 4: Department of Obsterics and Gynecology, Kaiser Permaente Medical Group, Mid-Atlantic Region, Baltimore, Md.; 5: Wyatt Company, Wellesley, Mass.; 6: Colorado Department of Health, Denver, Colo.; 7: Department of Obstetrics and Gynecology, Cornell University Medical College, New York, NY.; 8: Office of Population Affairs, US Department of Health and Human Services, Bethesda, Md.; 9: California Department of Health Services, Sacramento, California; 10: National Association of Nurse Practitioners in Reproductive Health, Washington, DC.; Issue Info: Apr95, Vol. 85 Issue 4, p494; Subject Term: Contraceptives; Subject Term: Medical care costs; Subject Term: Databases; Subject Term: Pregnancy; Subject Term: Vasectomy; Subject Term: Injectable contraceptives; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 10p; Illustrations: 6 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roscoe, Robert J.
AU - Deddens, James A.
AU - Salvan, Alberto
AU - Schnorr, Teresa M.
T1 - Mortality among Navajo Uranium Miners.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Article
SP - 535
EP - 540
PB - American Public Health Association
SN - 00900036
AB - Objectives. To update mortality risks for Navajo uranium miners, a retrospective cohort mortality study was conducted of 757 Navajos from the cohort of Colorado Plateau uranium miners. Methods. Vital status was followed from 1960 to 1990. Standardized mortality ratios were estimated, with combined New Mexico and Arizona non-white mortality rates used for comparison. Cox regression models were used to evaluate exposure-response relationships. Results. Elevated standardized mortality ratios were found for lung cancer (3.3), tuberculosis (2.6), and pneumoconioses and other respiratory diseases (2.6). Lowered ratios were found for heart disease (0.6), circulatory disease (0.4), and liver cirrhosis (0.5). The estimated relative risk for a 5-year duration of exposure vs none was 3.7 for lung cancer, 2.1 for pneumoconiosis and other respiratory diseases, and 2.0 for tuberculosis. The relative risk for lung cancer was 6.9 for the midrange of cumulative exposure to radon progeny compared with the least exposed. Conclusions. Findings were consistent with those from previous studies. Twenty-three years after their last exposure to radon progeny, these light-smoking Navajo miners continue to face excess mortality risks from lung cancer and pneumoconioawa and other respiratory diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Mortality
KW - Uranium miners
KW - Navajo (North American people)
KW - Lungs -- Cancer
KW - Colorado Plateau
N1 - Accession Number: 9504260432; Roscoe, Robert J. 1; Deddens, James A. 1,2; Salvan, Alberto 1,3; Schnorr, Teresa M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Department of Mathematical Sciences, University of Cincinnati; 3: LADSEB, National Research Council, Padova, Italy; Issue Info: Apr95, Vol. 85 Issue 4, p535; Thesaurus Term: Tuberculosis; Subject Term: Mortality; Subject Term: Uranium miners; Subject Term: Navajo (North American people); Subject Term: Lungs -- Cancer; Subject: Colorado Plateau; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107410659
T1 - Public health policy: creating a healthy future for the American public.
AU - Salmon ME
Y1 - 1995/04//1995 Apr
N1 - Accession Number: 107410659. Language: English. Entry Date: 19950601. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 7809641.
KW - Health Policy
KW - Public Policy
KW - Health Care Reform
KW - Health Maintenance Organizations
KW - Life Style
KW - Health Care Costs
KW - Health Promotion
KW - Outcomes (Health Care)
KW - Information Systems
KW - Health Personnel -- Education
KW - Research Support
KW - Health Resource Allocation
KW - National Health Programs
SP - 1
EP - 11
JO - Family & Community Health
JF - Family & Community Health
JA - FAM COMMUNITY HEALTH
VL - 18
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0160-6379
AD - Public Health Service, Department of Health and Human Services, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107429539
T1 - Biomechanics: the forces of change and the basis for all that we do.
AU - Bell-Krotoski JA
AU - Fess EE
Y1 - 1995/04//1995 Apr-Jun
N1 - Accession Number: 107429539. Language: English. Entry Date: 19951201. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8806591.
KW - Biomechanics
KW - Hand
KW - Hand Injuries -- Therapy
KW - Hand Injuries -- Rehabilitation
KW - Rehabilitation -- History
KW - Hand Surgery
SP - 63
EP - 67
JO - Journal of Hand Therapy
JF - Journal of Hand Therapy
JA - J HAND THER
VL - 8
IS - 2
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0894-1130
AD - US Public Health Service, Chief, Hand and Occupational Therapy Dept, Clinical Research Therapist, Gillis W Long Hansen's Disease Center, 5445 Point Clair Rd, Carville, LA 70721-9607
U2 - PMID: 7550630.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lensing, Shelly Y.
AU - Kodell, Ralph L.
T1 - Fitting the Two-Stage Clonal Expansion Model Based on Exact Hazard to the ED01 Data Using SAS NLIN.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1995/04//
VL - 15
IS - 2
M3 - Article
SP - 233
EP - 245
SN - 02724332
AB - The two-stage clonal expansion model is a popular model for carcinogenesis data. One common form of this model is based on the approximate hazard function. In certain situations, this formulation is not appropriate, and the exact hazard should be applied. However, the difficulty of implementing the model based on the exact hazard has deterred many from using it. This paper presents a program implementing the exact hazard model for piecewise constant dosing using SAS, a package that is readily available to most that are interested in this type of analysis. Also, an analysis of the ED[sub01] data is presented using this program, and comparisons are made to an earlier analysis based on the approximate hazard. By allowing for an independent background tumor mechanism, an excellent fit to the bladder tumor incidence data was obtained. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mathematical models
KW - Carcinogenesis
KW - Data analysis
KW - Health risk assessment
KW - Tumors
KW - Bladder
KW - additive background
KW - discontinuous dosing
KW - independent background
KW - MVK model
N1 - Accession Number: 11949305; Lensing, Shelly Y. 1; Kodell, Ralph L. 2; Affiliations: 1: Computer Sciences Corporation, National Center for Toxicological Research (HFT-20), Jefferson, Arkansas 72079-9502.; 2: Biometry and Risk Assessment, National Center for Toxicological Research (HFT-20), Jefferson, Arkansas 72079-9502.; Issue Info: Apr95, Vol. 15 Issue 2, p233; Thesaurus Term: Mathematical models; Thesaurus Term: Carcinogenesis; Thesaurus Term: Data analysis; Thesaurus Term: Health risk assessment; Subject Term: Tumors; Subject Term: Bladder; Author-Supplied Keyword: additive background; Author-Supplied Keyword: discontinuous dosing; Author-Supplied Keyword: independent background; Author-Supplied Keyword: MVK model; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107260062
T1 - Healthy People 2000 at mid decade.
AU - McGinnis JM
AU - Lee PR
AU - McGinnis, J M
AU - Lee, P R
Y1 - 1995/04/12/
N1 - Accession Number: 107260062. Language: English. Entry Date: 19980501. Revision Date: 20161112. Publication Type: journal article; tables/charts. Commentary: Heeb M A. The role of schools in Healthy People 2000. (JAMA) 10/18/95; 274 (15): 1195-1196. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Health Promotion -- United States
KW - Public Health -- Trends -- United States
KW - United States
SP - 1123
EP - 1129
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 273
IS - 14
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - US Public Health Service, Washington, DC 20201, USA
AD - US Public Health Service, 330 C St SW, Room 2132, Washington, DC 20201
U2 - PMID: 7707601.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Crane, Nancy T.
AU - Wilson, Dennis B.
AU - Lewis, Christine J.
AU - Cook, D. Annetta
AU - Rader, Jeanne I.
AU - Yetley, Elizabeth A.
T1 - Evaluating Food Fortification Options: General Principles Revisited with Folic Acid.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/05//
VL - 85
IS - 5
M3 - Article
SP - 660
EP - 666
PB - American Public Health Association
SN - 00900036
AB - Objectives. This article uses folic acid as an example to illustrate some of the complex issues and general principles that emerge when evaluating fortification of the food supply as one possible means to address a public health recommendation. Methods. Distributions of current daily folate intakes from conventional foods and dietary supplements were estimated. Intakes that might result from fortification of cereal-grain products and ready-to-eat cereals at various levels for eight age-gender groups were also estimated by using the US Department of Agriculture's 1987-1988 Nationwide Food Consumption Survey. Results. The results illustrate that fortification of the US food supply tends to increase folate intakes of consumers at the high end of the intake distribution curves in the target population. Conclusions. The effectiveness of food fortification options for a target population and the safety for the general population impose conflicting challenges that must be considered concurrently when making decisions about fortifying the US food supply. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enriched foods
KW - Public health
KW - Cereal products
KW - Food supply
KW - Folic acid
KW - United States
N1 - Accession Number: 9505300899; Crane, Nancy T. 1; Wilson, Dennis B. 1; Lewis, Christine J. 1; Cook, D. Annetta 2; Rader, Jeanne I. 3; Yetley, Elizabeth A. 3; Affiliations: 1: Center for Food Safety and applied Nutrition, Food and Drug Administration, Washington, DC; 2: Agricultural Research Services, US Department of Agriculture, Washington, DC; 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Issue Info: May95, Vol. 85 Issue 5, p660; Thesaurus Term: Enriched foods; Thesaurus Term: Public health; Thesaurus Term: Cereal products; Thesaurus Term: Food supply; Subject Term: Folic acid; Subject: United States; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Biener, Lois
AU - Heaton, Alan
T1 - Women Dieters of Normal Weight: Their Motives, Goals, and Risks.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/05//
VL - 85
IS - 5
M3 - Article
SP - 714
EP - 717
PB - American Public Health Association
SN - 00900036
AB - Using data from a national survey of weight loss practices, this study examined those dieters who were of normal weight. Forty-Seven percent of White women, 25% of Black women, and 16% of men currently trying to lose weight had a body mass index under 25. Women's primary motive was health improvement. Among normal-weight female dieters, 12% of Whites and 27% of Blacks were using risky strategies. Dieters were less likely than nondieters to smoke and reported better nutritional practices; however, they were not more likely to exercise, and their maximum weight fluctuation was 50% greater. Additional research on the consequences of dieting among normal-weight individuals is of high priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Reducing diets
KW - Women
KW - Motivation (Psychology)
KW - Racial differences
KW - Body mass index
KW - Risk-taking (Psychology)
N1 - Accession Number: 9505300918; Biener, Lois 1; Heaton, Alan 2; Affiliations: 1: Center for Survey Research, University of Massachusetts, Boston; 2: US Food and Drug Administration, Washington, DC; Issue Info: May95, Vol. 85 Issue 5, p714; Thesaurus Term: HEALTH; Subject Term: Reducing diets; Subject Term: Women; Subject Term: Motivation (Psychology); Subject Term: Racial differences; Subject Term: Body mass index; Subject Term: Risk-taking (Psychology); Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107413600
T1 - Dietary guidance workshop helps tribal program cooks make changes.
AU - Pelican S
AU - Proulx JM
AU - Wilde J
AU - Del Vecchio A
Y1 - 1995/05//
N1 - Accession Number: 107413600. Language: English. Entry Date: 19950801. Revision Date: 20150819. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Funded, in part, by a grant (091090-B) from the American Dietetic Association Foundation. NLM UID: 7503061.
KW - Program Evaluation
KW - Nutrition Education
KW - Education, Dietetics
KW - Survey Research
KW - Questionnaires
KW - Knowledge
KW - Native Americans
KW - Cooking
KW - Outcomes of Education
KW - Funding Source
KW - Human
SP - 591
EP - 592
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 95
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Indian Health Service Nutrition and Dietetics Training Program, Santa Fe, NM
U2 - PMID: 7722198.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Horton, L. R.;
T1 - International update
CT - International update
JO - PDA Journal of Pharmaceutical Science and Technology (USA)
JF - PDA Journal of Pharmaceutical Science and Technology (USA)
Y1 - 1995/05/01/
VL - 49
IS - May-Jun
SP - 106
EP - 110
SN - 1076397X
AD - Office of the Commissioner (HF-23), Food and Drug Administration, Rm. 15-74, 5600 Fishers Ln., Rockville, MD 20857, USA
N1 - Accession Number: 32-12418; Language: English; Journal Coden: JPHTEU; Section Heading: Legislation, Laws and Regulations; Abstract Author: Elizabeth G. Rudnic
N2 - An overview of the U.S. Food and Drug Administration's (FDA) role in world trade in 1994, including formulation of a strong coherent approach to harmonization and increased activity on regulatory use standards, is presented.
KW - Food and Drug Administration (U.S.)--role--world trade;
KW - Regulations--Food and Drug Administration--world trade;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107410970
T1 - The role of Army physical therapists as nonphysician health care providers who prescribe certain medications: observations and experiences.
AU - Benson CJ
AU - Schreck RC
AU - Underwood FB
AU - Greathouse DG
Y1 - 1995/05//
N1 - Accession Number: 107410970. Language: English. Entry Date: 19950701. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0022623.
KW - Military Personnel
KW - Physical Therapy
KW - Prescriptive Authority -- History
KW - Diagnosis, Musculoskeletal
KW - Role
SP - 380
EP - 386
JO - Physical Therapy
JF - Physical Therapy
JA - PHYS THER
VL - 75
IS - 5
CY - Alexandria, Virginia
PB - American Physical Therapy Association
AB - For two decades, Army physical therapists have been granted limited privileges to prescribe certain medications when serving as nonphysician health care providers for the primary evaluation and treatment of patients with neuromusculoskeletal dysfunctions. A brief summary of the events that led to this physician-extender role is presented. This article describes the Army regulations, credentialing process, and expanded clinical privileges developed to prepare and support physical therapists working as primary neuromusculoskeletal screeners who are credentialed to order certain pharmacologic medications. A historical synopsis of Army physical therapists ordering pharmacologic medications in their expanded role as nonphysician health care providers is also presented. Results of a 1994 Army-wide survey of physical therapy clinics are provided in terms of medications prescribed and observations by those involved. The educational opportunities designed to ensure safe and appropriate uses of these privileges are described.
SN - 0031-9023
AD - Army Medical Specialist Corps, Headquarters, US Department of the Army, Office of the Surgeon General, 5109 Leesburg Pike, Falls Church, VA 22041
U2 - PMID: 7732082.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Finn, Theresa M.
AU - Stevens, Lisa A.
T1 - Tracheal colonization factor: a Bordetella pertussis secreted virulence determinant.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1995/05/15/
VL - 16
IS - 4
M3 - Article
SP - 625
EP - 634
PB - Wiley-Blackwell
SN - 0950382X
AB - We report here the identification of a virulence-associated factor, Tcf, (tracheal colonization factor), produced by strains of Bordetella pertussis but not Bordetella parapertussis or Bordetella bronchiseptica . This protein is encoded by the tcfA gene. When a strain of B. pertussis 18323 lacking this protein is used to infect mice with an aerosol challenge, the number of bacteria isolated from the tracheas is decreased 10-fold when compared with the parent 18323. The derived amino acid sequence of tcfA predicts a 68 kDa RGD-containing, proline-rich protein, which after cleavage of a typical prokaryotic signal sequence would be 64 kDa. Amino acid sequence analysis demonstrates that the C-terminal 30 kDa of this protein shows 50% identity to the 30 kDa C-terminus of another Bordetella protein, the pertactin precursor. The N-terminal 34 kDa region contains the three amino-acid motif RGD and is 16.5% proline. Coupled in vitro transcription and translation analysis indicates that the tcfA gene product migrates as two bands of approximately 90 kDa. A fusion protein of the N-terminal, 34 kDa portion of Tcf to maltose-binding protein migrates, on SDS-PAGE, 30 kDa higher than expected from the combined molecular weights. Polyclonal antisera raised against the unique N-terminal portion of Tcf recognizes 90 kDa and 60 kDa bands in immunoblots of whole-cell lysates of strains of B. pertussis ; it does not recognize any protein in whole-cell lysates of B. bronchiseptica or B. parapertussi s. Supernatants of cultures of B. pertussis 18323 contain the 60 kDa form of the protein. Southern blot analysis of chromosomal DNA from strains of B. bronchiseptica and B. parapertussis , using a probe derived from tcfA , shows strong hybridization only to B. pertussis DNA. Thus, Tcf appears to be a unique virulence factor of B. pertussis . [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virulence (Microbiology) -- Molecular aspects
KW - Bordetella pertussis
KW - Trachea
KW - Amino acid sequence
KW - Immunoblotting -- Diagnostic use
N1 - Accession Number: 16169244; Finn, Theresa M. 1; Email Address: finn@cber.cber.fda.gov; Stevens, Lisa A. 2,3; Affiliations: 1: Laboratory of Pertussis, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892-0029, USA; 2: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; 3: Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114; Issue Info: May1995, Vol. 16 Issue 4, p625; Subject Term: Virulence (Microbiology) -- Molecular aspects; Subject Term: Bordetella pertussis; Subject Term: Trachea; Subject Term: Amino acid sequence; Subject Term: Immunoblotting -- Diagnostic use; Number of Pages: 10p; Illustrations: 7 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Ordin, Diana L.
AU - Fine, Lawrence J.
T1 - Editorial: Surveillance for Pesticide-Related Illness--Lessons From California.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/06//
VL - 85
IS - 6
M3 - Editorial
SP - 762
EP - 763
PB - American Public Health Association
SN - 00900036
AB - This article reflects on the effectiveness of the surveillance system for pesticide-related illnesses in California. Like its overall approach to pesticide regulation, the worker safety program in the California Department of Pesticide Regulation is the most stringent in the U.S. The surveillance system in California offers routine information crucial for prevention. An estimate of the magnitude of the problem of pesticide-related illness is being offered by the system, it also identifies clusters and previously unrecognized problems, elucidates risk factors and identifies high-risk workers, workplaces and work practices.
KW - Epidemiology
KW - Pesticides -- Risk mitigation
KW - Industrial safety
KW - Diseases
KW - Public health surveillance
KW - California
KW - California Environmental Protection Agency. Dept. of Pesticide Regulation
N1 - Accession Number: 9506200462; Ordin, Diana L. 1; Fine, Lawrence J.; Affiliations: 1: Division of Surveillance, Hazard Evolutions, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jun95, Vol. 85 Issue 6, p762; Thesaurus Term: Epidemiology; Thesaurus Term: Pesticides -- Risk mitigation; Thesaurus Term: Industrial safety; Thesaurus Term: Diseases; Subject Term: Public health surveillance; Subject: California ; Company/Entity: California Environmental Protection Agency. Dept. of Pesticide Regulation; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Houn, Florence
AU - Helzlsouer, Kathy J.
AU - Friedman, Neil B.
AU - Stefanek, Michael E.
T1 - The Practice of Prophylactic Mastectomy: A Survey of Maryland Surgeons.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/06//
VL - 85
IS - 6
M3 - Article
SP - 801
EP - 805
PB - American Public Health Association
SN - 00900036
AB - Objectives. Bilateral prophylactic mastectomy is a drastic breast cancer preventive option for which indications are not standardized and efficacy has not been proven. To estimate the magnitude of this controversial practice, surgeons were surveyed on their recommendations about and performance of prophylactic mastectomy. Methods. A cross-sectional survey was sent to general surgeons (n=522), plastic surgeons (n=80), and gynecologists (n=801) licensed to practice in Maryland in 1992. Proportions responding were 41.9%, 66.3%, and 54.9%, respectively. In addition, there were 30 respondents who identified "other" as their specialty. The respondents were asked about the role of bilateral prophylactic mastectomy and the number of time they had recommended and performed it in a year. Results. Seven hundred forty-two surgeons responded (51.8%). More plastic surgeons (84.6%) than general surgeons (47.0%) and gynecologists (38.3%) agreed that bilateral prophylactic mastectomy has a role in the care of high-risk women. Eighty-one percent of plastic surgeons had recommended the procedure, compared with 38.8% of general surgeons and 17.7% of gynecologists. Conclusions. Indications and practice patterns reveal heterogeneity of medical opinion and practice of prophylactic mastectomy. This study raises the need for better evaluation of the efficacy and appropriateness of prophylactic mastectomy. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mastectomy
KW - Breast cancer -- Surgery
KW - Breast cancer
KW - Surgeons
KW - Surveys
KW - Plastic surgery
N1 - Accession Number: 9506200481; Houn, Florence 1,2; Helzlsouer, Kathy J. 3,4; Friedman, Neil B. 5; Stefanek, Michael E. 4; Affiliations: 1: Division of Mammography Quality and Radiation Programs, Food and Drug Administration, Rockville, Md; 2: Oncology Center, Johns Hopkins Hospital, Baltimore, Md; 3: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health; 4: Oncology Center, Johns Hopkins Hospital; 5: Department of Surgery, Johns Hopkins Hospital; Issue Info: Jun95, Vol. 85 Issue 6, p801; Subject Term: Mastectomy; Subject Term: Breast cancer -- Surgery; Subject Term: Breast cancer; Subject Term: Surgeons; Subject Term: Surveys; Subject Term: Plastic surgery; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Waldman, Robert J.
T1 - Peacekeeping: Challenges for the Future.
JO - Armed Forces & Society (0095327X)
JF - Armed Forces & Society (0095327X)
J1 - Armed Forces & Society (0095327X)
PY - 1995///Summer95
Y1 - 1995///Summer95
VL - 21
IS - 4
M3 - Book Review
SP - 677
EP - 679
PB - Sage Publications Inc.
SN - 0095327X
AB - The article reviews the book "Peacekeeping: Challenges for the Future," edited by Hugh Smith.
KW - PEACEKEEPING: Challenges for the Future (Book)
KW - SMITH, Hugh
KW - PEACEKEEPING forces
KW - NONFICTION
N1 - Accession Number: 9508230647; Source Information: Summer95, Vol. 21 Issue 4, p677; Subject Term: PEACEKEEPING: Challenges for the Future (Book); Subject Term: SMITH, Hugh; Subject Term: PEACEKEEPING forces; Subject Term: NONFICTION; Subject Term: ; Number of Pages: 3p; ; Document Type: Book Review; ; Full Text Word Count: 809;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - O'Hanlon, T. P.
AU - Messersmith, W. A.
AU - Dalakas, M. C.
AU - Plot, P. H.
AU - Miller, F. W.
T1 - γδ T cell receptor gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1995/06//
VL - 100
IS - 3
M3 - Article
SP - 519
EP - 528
SN - 00099104
AB - Autoreactive αβ T cells have been implicated as playing a primary pathogenic role in a group of diseases characterized by chronic muscle inflammation known as the idiopathic inflammatory myopathies (IIM). γδ T cells, a distinct and enigmatic class of 'T cells, play a less certain role in a variety of human autoimmune diseases including the IIM. In an attempt to understand the significance of γδ T cells in the IIM, we utilized a sensitive polymerase chain reaction (PCR) technique to evaluate γδ T cell receptor (TCR) gene expression in 45 muscle biopsies obtained from 42 IIM patients (17 polymyositis. 12 dermatomyositis, and 13 inclusion body myositis). γδ TCR gene expression was not detected in 36 specimens, the majority of muscle biopsies surveyed. γδ TCR gene expression by muscle-infiltrating lymphocytes was detected among nine clinically heterogeneous patients. We further analysed the functional sequence composition of the Vγ3 and Vδ1 transcripts, whose expression was prominent among γδ positive patients. DNA sequence analysis of Vγ3 amplification products from two patients revealed the presence of several productively rearranged transcripts with amino acid sequence similarities within the Vγ3-N-Jγ junctional domain. No amino acid sequence similarities were evident within the Vδ-N-Dδ-N-Jδ region of Vδ1 transcripts amplified from four patients, although a distinct and dominant clonotype was detected from each patient. Our cumulative data suggest that unlike αβ T cells, γδ T cells do not play a prominent pathologic role in the IIM. In fact, the sporadic nature of γδ TCR gene expression detected among these patients implies that γδ T cell infiltration, when it occurs, is a secondary event perhaps resulting from non-specific inflammatory processes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - CELL receptors
KW - LYMPHOCYTES
KW - INFLAMMATION
KW - MUSCLES
KW - POLYMYOSITIS
KW - γ&delta T cells
KW - myositis
KW - T cell receptors
N1 - Accession Number: 16194786; O'Hanlon, T. P. 1; Messersmith, W. A. 1; Dalakas, M. C. 2; Plot, P. H. 3; Miller, F. W. 1; Source Information: Jun1995, Vol. 100 Issue 3, p519; Subject: T cells; Subject: CELL receptors; Subject: LYMPHOCYTES; Subject: INFLAMMATION; Subject: MUSCLES; Subject: POLYMYOSITIS; Author-Supplied Keyword: γ&delta T cells; Author-Supplied Keyword: myositis; Author-Supplied Keyword: T cell receptors; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Trout, Douglas
AU - Gomez, Thomas M.
AU - Bernard, Bruce P.
AU - Mueller, Charles A.
AU - Smith, C Gregory
AU - Hunter, Lee
AU - Kiefer, Max
T1 - Outbreak of Brucellosis at a United States Pork Packing Plant.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/06//
VL - 37
IS - 6
M3 - Article
SP - 697
EP - 703
SN - 00961736
AB - In 1992, the North Carolina Department of Environment, Health, and Natural Resources received 18 case reports of brucellosis from a county health department. All patients had potential exposure to the kill floor of one pork processing plant. A subsequent National Institute for Occupational Safety and Health health hazard evaluation surveyed 154 (99%) of 156 kill floor workers of this plant and found that 30 (19%) had evidence of recent (or persistent) brucellosis. These data show that significant exposure to Brucella is occurring among packing plant workers in North Carolina and suggest that some of the approximately 38,000 production workers in pork processing plants in the United States are at risk of contracting swine brucellosis. Additional measures may need to be taken to prevent occupational exposure to Brucella. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379836; Trout, Douglas 1; Gomez, Thomas M. 1; Bernard, Bruce P. 1; Mueller, Charles A. 1; Smith, C Gregory 1; Hunter, Lee 1; Kiefer, Max 1; Source Information: Jun1995, Vol. 37 Issue 6, p697; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Amandus, H E
AU - Hunter, R D
AU - James, E
AU - Hendricks, S
T1 - Reevaluation of the Effectiveness of Environmental Designs to Reduce Robbery Risk in Florida Convenience Stores.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/06//
VL - 37
IS - 6
M3 - Article
SP - 711
EP - 717
SN - 00961736
AB - Prevention of intentional injuries to convenience store workers has focused on prevention of robbery. Data from a cross-sectional study of the effectiveness of environmental designs to deter robbery in Florida convenience stores were reanalyzed in order to determine the effect of confounding from local crime risk factors and other environmental designs on robbery rate. Results of this reanalysis were applied to a review of the literature.Of 14 store design factors and 5 local crime risk factors considered, concealed access/escape routes, cash register located at the back or the side of the store, high county crime rate, and high county population size were significantly associated with increased robbery rate. Poor cash handling policy was significantly related to a decreased robbery rate. Results also indicated that local crime factors and some environmental designs confound the relationship between other environmental designs and robbery rate.Conclusions from this reanalysis indicated that studies of the effectiveness of environmental designs to deter robbery must adjust for confounding. Although environmental design tends to be an effective robbery deterrent strategy, results from studies have been inconsistent as to the effectiveness of specific design factors. This inconsistency is partially explained by lack of adjustment for confounding from local crime risk factors and multiple environmental design factors. Areas for further research are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379839; Amandus, H E 1; Hunter, R D 1; James, E 1; Hendricks, S 1; Source Information: Jun1995, Vol. 37 Issue 6, p711; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Elders, M. Joycelyn
T1 - The Role of Public Health in Improving the Health of America.
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 1995///Summer1995
VL - 16
IS - 2
M3 - Article
SP - 133
EP - 141
SN - 01975897
AB - The article is a keynote address by the author to the members of American Public Health Association. He thanks all the members for their contribution to the public health. He thanked the members for their role in prevention of epidemics, protecting environment, preventing spread of HIV disease,and preventing unintentional injuries. He also mentions their response to the natural disasters has been commendable. He discusses the floods at Georgia, that caused havoc, as water level reached roof top of the buildings. He was impressed with courage, hope and resiliency, that community has put their lives back together. He suggests that one has to continuously strive to face the challenges due to poverty. He says that future focus should lie on preventive aspects. He says that to have access to high quality healthcare to the poor should be the motive. He says that the professionals must reach out and be responsible, be willing to take some risks. They must continue with high quality research and try to develop a vaccine for HIV. Professionals must make endeavors to educate themselves and the community to be healthy Americans.
KW - Public health
KW - Natural disasters
KW - AIDS (Disease)
KW - Medical care -- United States
KW - Professional ethics
KW - PREVENTION
KW - United States
KW - Keynote address
KW - Public health status
KW - Statistics
KW - USA
KW - American Public Health Association
N1 - Accession Number: 8181865; Elders, M. Joycelyn 1; Affiliations: 1: Surgeon General, U.S. Public Health Service.; Issue Info: Summer1995, Vol. 16 Issue 2, p133; Thesaurus Term: Public health; Thesaurus Term: Natural disasters; Thesaurus Term: AIDS (Disease); Subject Term: Medical care -- United States; Subject Term: Professional ethics; Subject Term: PREVENTION; Subject: United States; Author-Supplied Keyword: Keynote address; Author-Supplied Keyword: Public health status; Author-Supplied Keyword: Statistics; Author-Supplied Keyword: USA ; Company/Entity: American Public Health Association; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scheuplein, Robert J.
AU - Bowers, John C.
T1 - Dioxin--An Analysis of the Major Human Studies: Comparison with Animal-Based Cancer Risks.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1995/06//
VL - 15
IS - 3
M3 - Article
SP - 319
EP - 333
SN - 02724332
AB - Several major epidemiological studies have reported significant mortality rates (SMRs) for both rare cancers (soft tissue sarcoma, non-Hodgkin's, lymphoma, liver) and the more common cancers (lung, colon, etc), all allegedly caused by TCDD. In this paper, we use the potency of TCDD in animals to establish a plausible worst case cancer risk and ask whether its likely that TCDD is responsible for the epidemiological findings assuming the animal carcinogenic potency is applicable to the conditions of human exposure. Two new features of the technique are the use of measured TCDD blood levels in both animals and humans for dose scale-up and the calculation of an integrated life-time exposure for the exposed workers using measured blood levels. On the basis of the stated assumptions it appears unlikely that any of the major epidemiological studies, with the possible exception of the NIOSH study have adequate power to detect the common cancers potentially caused by TCDD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animals
KW - Dioxins
KW - Demography
KW - Epidemiology
KW - Cancer -- Study & teaching
KW - Human beings
KW - Mortality
KW - Social indicators
KW - cancer risk
KW - Dioxin
KW - dioxin blood levels.
KW - pharmacokinetics
N1 - Accession Number: 11762703; Scheuplein, Robert J. 1; Bowers, John C. 2; Affiliations: 1: Weinburg Consultant Group Inc., 1220 Nineteenth Street, N.W., Suite 300, Washington, D.C. 20036-2400.; 2: Mathematics, Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition Food and Drug Administration, 200 C St. S.W., Washington, D.C. 20204.; Issue Info: Jun95, Vol. 15 Issue 3, p319; Thesaurus Term: Animals; Thesaurus Term: Dioxins; Thesaurus Term: Demography; Thesaurus Term: Epidemiology; Subject Term: Cancer -- Study & teaching; Subject Term: Human beings; Subject Term: Mortality; Subject Term: Social indicators; Author-Supplied Keyword: cancer risk; Author-Supplied Keyword: Dioxin; Author-Supplied Keyword: dioxin blood levels.; Author-Supplied Keyword: pharmacokinetics; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Infant Mortality in the United States: Trends, Differentials, and Projections, 1950 through 2010.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/07//
VL - 85
IS - 7
M3 - Article
SP - 957
EP - 964
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined long-term trends and differences in infant mortality in the United States from 1950 through 1991 according to race and ethnicity, education, family income, and cause of death. Forecasts are made through the year 2010. Methods. Los-linear regression models were applied to data from the National Vital Statistics System, National Linked Birth and Infant Death files, the National Maternal and Infant Health Survey, the National Natality Survey, and the National Infant Mortality Survey to model and forecast infant mortality. Results. Dramatic declines in the US infant mortality rate have occurred in the past 4 decades, largely as a result of declines in mortality from pneumonia and influenza, respiratory distress syndrome, prematurity and low birthweight, congenital anomalies, and accidents. Despite the overall reductions, however, substantial racial/ethnic, educational, and income differences in infant mortality still exist. Conclusions. The long-term downward trend in US infant mortality has not benefited Blacks and Whites equally. The Black/White disparity in infant mortality has not only persisted but increased over time and is not expected to diminish in the near future. Educational inequalities have also widened, and racial disparities have generally increased across all educational levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Infant mortality
KW - Regression analysis
KW - Race
KW - Ethnicity
KW - Respiratory distress syndrome
KW - Low birth weight
KW - Health surveys
KW - United States
KW - HEALTH—MEDICAL
N1 - Accession Number: 9508091232; Singh, Gopal K. 1; Yu, Stella M. 2; Affiliations: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md; 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md; Issue Info: Jul1995, Vol. 85 Issue 7, p957; Subject Term: Infant mortality; Subject Term: Regression analysis; Subject Term: Race; Subject Term: Ethnicity; Subject Term: Respiratory distress syndrome; Subject Term: Low birth weight; Subject Term: Health surveys; Subject: United States; Author-Supplied Keyword: HEALTH—MEDICAL; Number of Pages: 8p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107359077
T1 - Performance of community health centers under managed care.
AU - Abrams R
AU - Savela T
AU - Trinity MT
AU - Falik M
AU - Tutunjian B
AU - Ulmer C
Y1 - 1995/07//1995 Jul
N1 - Accession Number: 107359077. Language: English. Entry Date: 19960201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 7802876.
KW - Community Health Services
KW - Managed Care Programs
KW - Health Maintenance Organizations
KW - Primary Health Care
KW - Questionnaires
KW - Interview Guides
KW - United States
KW - Capitation Fee
KW - Utilization Review
KW - Health Care Costs
KW - Health Services Research
KW - Community Health Services -- Administration
KW - Human
SP - 77
EP - 88
JO - Journal of Ambulatory Care Management
JF - Journal of Ambulatory Care Management
JA - J AMBULATORY CARE MANAGE
VL - 18
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The Bureau of Primary Health Care, a division of the Health Resources and Services Administration of the Department of Health and Human Services, Public Health Service, commissioned a study to evaluate the performance of community health centers (CHCs) under managed care. This article reports on the findings of the bureau's study, which examined the managed performance of seven CHCs that contract with health maintenance organizations (HMOs). The experiences of these centers can provide valuable insights for other CHCs and the HMOs with which they partner. Policy makers contemplating the role of CHCs in managed care will also benefit from these findings.
SN - 0148-9917
AD - Health Resources and Services Administration, Bethesda, Maryland
U2 - PMID: 10143482.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107358683
T1 - Information sources of US adults trying to lose weight.
AU - Heaton AW
AU - Levy AS
Y1 - 1995/07//Jul/Aug95
N1 - Accession Number: 107358683. Language: English. Entry Date: 19960201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. Instrumentation: Weight Loss Practices Survey (WLPS). NLM UID: 0246004.
KW - Weight Loss
KW - Health Information
KW - Information Seeking Behavior
KW - United States
KW - Probability Sample
KW - Telephone
KW - Surveys
KW - Research Instruments
KW - Sampling Methods
KW - Body Mass Index
KW - Chi Square Test
KW - Comparative Studies
KW - Descriptive Statistics
KW - Sex Factors
KW - Age Factors
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 182
EP - 190
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
JA - J NUTR EDUC
VL - 27
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0022-3182
AD - Division of Market Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anttila, Ahti
AU - Pukkala, Eero
AU - Sallmén, Markku
AU - Hernberg, Sven
AU - Hemminki, Kari
T1 - Cancer Incidence among Finnish Workers Exposed to Halogenated Hydrocarbons.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/07//
VL - 37
IS - 7
M3 - Article
SP - 797
EP - 806
SN - 00961736
AB - Epidemiologic studies and long-term carcinogenicity studies in experimental animals suggest that some halogenated hydrocarbons are carcinogenic. To investigate whether exposure to trichloroethylene, tetrachloroethylene, or 1,1,1-trichloroethane increases carcinogenic risk, a cohort of 2050 male and 1924 female workers monitored for occupational exposure to these agents was followed up for cancer incidence in 1967 to 1992. The overall cancer incidence within the cohort was similar to that of the Finnish population. There was an excess of cancers of the cervix uteri and lymphohematopoietic tissues, however. Excess of pancreatic cancer and non-Hodgkin lymphoma was seen after 10 years from the first personal measurement. Among those exposed to trichloroethylene, the overall cancer incidence was increased for a follow-up period of more than 20 years. There was an excess of cancers of the stomach, liver, prostate, and lymphohematopoietic tissues combined. Workers exposed to 1,1,1-trichloroethane had increased risk of multiple myeloma and cancer of the nervous system. The study provides support to the hypothesis that trichloroethylene and other halogenated hydrocarbons are carcinogenic for the liver and lymphohematopoietic tissues, especially for non-Hodgkin lymphoma. The study also documents excess of cancers of the stomach, pancreas, cervix uteri, prostate, and the nervous system among workers exposed to solvents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379815; Anttila, Ahti 1; Pukkala, Eero 1; Sallmén, Markku 1; Hernberg, Sven 1; Hemminki, Kari 1; Source Information: Jul1995, Vol. 37 Issue 7, p797; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107358170
T1 - Historical assessment and future directions in the prevention of occupational hearing loss.
AU - Merry CJ
AU - Franks JR
Y1 - 1995/07//1995 Jul-Sep
N1 - Accession Number: 107358170. Language: English. Entry Date: 19960201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Occupational-Related Injuries -- Prevention and Control
KW - Occupational Safety -- Trends
KW - Medically Underserved
KW - Ear Protective Devices
KW - United States Occupational Safety and Health Administration
KW - Program Development
KW - Occupational Exposure
KW - Staff Development
SP - 669
EP - 681
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 10
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - The progress of regulatory action designed to control noise exposure is assessed. Other topics include progress in the development and assessment of hearing conservation programs, exposure assessment, hearing protection devices, and training and motivation.
SN - 0885-114X
AD - Bioacoustics and Occupational Vibration Section, Physical Agents Effects Branch, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop C27, Cincinnati, OH 45226
U2 - PMID: 8578427.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2007-10491-001
AN - 2007-10491-001
AU - Straw, Roger B.
T1 - Looking behind the numbers in counting the homeless: An invited commentary.
T3 - Dilemmas in counting the homeless
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1995/07//
VL - 65
IS - 3
SP - 330
EP - 333
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
AD - Straw, Roger B., U.S. Department of Health and Human Services, Public Health Service, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 11C-26, Rockville, MD, US, 20857
N1 - Accession Number: 2007-10491-001. PMID: 7485417 Partial author list: First Author & Affiliation: Straw, Roger B.; Division of Demonstration Programs, Center for Mental Health Services, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20070716. Correction Date: 20160922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Homeless; Housing; Measurement; Population (Statistics). Classification: Social Processes & Social Issues (2900). References Available: Y. Page Count: 4. Issue Publication Date: Jul, 1995. Copyright Statement: American Orthopsychiatric Association, Inc. 1995.
AB - Comments on the original article 'Housing dynamics of the homeless: Implications for a count,' by James D. Wright and Joel E. Devine (see record [rid]2007-10495-001[/rid]). Many of criticisms of the Census Bureau's S-Night count of the homeless advanced by Wright and Devine (1995) are appropriate. However, a more important issue--the lack of agreement in the field on an appropriate conceptual definition of homelessness--undermines their overall critique. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homeless count
KW - homelessness
KW - housing dynamics
KW - housing history
KW - Census Bureau
KW - S-Night count
KW - 1995
KW - Homeless
KW - Housing
KW - Measurement
KW - Population (Statistics)
KW - 1995
DO - 10.1037/h0085058
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107421511
T1 - Pharmacist consult. Avoiding hazards with liquid dosing devices.
AU - Couig MP
Y1 - 1995/08//
N1 - Accession Number: 107421511. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Administration, Oral -- Adverse Effects
KW - Syringes
SP - 76
EP - 76
JO - Nursing
JF - Nursing
JA - NURSING
VL - 25
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Office of Health Affairs, Food and Drug Administration, Rockville, Md.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Qi Zheng
T1 - On the MVK Stochastic Carcinogenesis Model with Erlang Distributed Cell Life Lengths.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1995/08//
VL - 15
IS - 4
M3 - Article
SP - 495
EP - 502
SN - 02724332
AB - This paper proposes extending the MVK carcinogenesis model by adopting the Erlang distribution for the life length of the intermediate cells. The investigation concentrates on the survival function and the mean value functions. The approach is basically numerical, making use of the Mathematica software system. The paper also provides a closed form expression for the survival function for a variation of the original MVK model, where all the model parameters are piecewise constants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mathematical models
KW - Carcinogenesis
KW - Cells
KW - Survival analysis (Biometry)
KW - Computer software
KW - Cells -- Mechanical properties
KW - Mathematical programming
KW - characteristic curve
KW - device of stages
KW - Mathematica programming.
KW - Survival function
N1 - Accession Number: 11782667; Qi Zheng 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, HFT-20, 3900 NCTR Drive, Jefferson, Arkansas 72079-9502.; Issue Info: Aug95, Vol. 15 Issue 4, p495; Thesaurus Term: Mathematical models; Thesaurus Term: Carcinogenesis; Subject Term: Cells; Subject Term: Survival analysis (Biometry); Subject Term: Computer software; Subject Term: Cells -- Mechanical properties; Subject Term: Mathematical programming; Author-Supplied Keyword: characteristic curve; Author-Supplied Keyword: device of stages; Author-Supplied Keyword: Mathematica programming.; Author-Supplied Keyword: Survival function; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bell, T. A.
T1 - New animal drug approvals and the United States aquaculture industry: a partnership for growth.
JO - Aquaculture Research
JF - Aquaculture Research
Y1 - 1995/09//
VL - 26
IS - 9
M3 - Article
SP - 679
EP - 685
PB - Wiley-Blackwell
SN - 1355557X
AB - Aquaculture, for better or worse, depends in part on drugs for the prevention, control and eradication of a variety of diseases. The US Food and Drug Administration's Centre for Veterinary Medicine, through the Federal Food, Drug and Cosmetic Act, strictly controls the approval and use of drugs in animals, including aquatic animals. Laws and regulations exist that regulate the investigational use and approval of new animal drugs for all animals. However, in reality, these mandates must be uniquely interpreted for aquatic species. Very few drugs are approved for use in aquatic species. There is a growing effort by non-traditional sponsors (aquaculturists as opposed to pharmaceutical firms) to gain approvals for several new animal drugs. Simultaneously, the federal government, including the Centre for Veterinary Medicine, is working aggressively with the private and public aquaculture sectors to facilitate submission and subsequent approval of new animal drug applications. The drug approval procedures and requirements for aquatic animals are discussed. Special attention is given to their similarities and differences, relative to traditional terrestrial animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aquaculture Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aquaculture
KW - Aquatic animals
KW - Veterinary drugs
KW - Drug approval
KW - Veterinary therapeutics
KW - United States
KW - Center for Veterinary Medicine (U.S.)
N1 - Accession Number: 18280909; Bell, T. A. 1; Affiliations: 1: US Food and Drug Administration, Centre for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Food Animals, Aquaculture Group, Maryland, USA; Issue Info: Sep1995, Vol. 26 Issue 9, p679; Thesaurus Term: Aquaculture; Thesaurus Term: Aquatic animals; Subject Term: Veterinary drugs; Subject Term: Drug approval; Subject Term: Veterinary therapeutics; Subject: United States ; Company/Entity: Center for Veterinary Medicine (U.S.); NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104779443
T1 - Measuring quality of life in a reformed health system.
AU - Lehman, A F
Y1 - 1995///Fall1995
N1 - Accession Number: 104779443. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Instrumentation: Health-Related Quality of Life (HRQOL). NLM UID: 8303128.
KW - Disabled
KW - Health Care Reform -- Economics
KW - Mental Disorders -- Therapy
KW - Quality-Adjusted Life Years
KW - Chronic Disease
KW - Contract Services -- Economics
KW - Cost Control
KW - Mental Disorders -- Economics
KW - Mental Health Services -- Economics
KW - Treatment Outcomes
KW - United States
SP - 90
EP - 101
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 14
IS - 3
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - 'Quality of life' encompasses functional status, access to resources and opportunities, and sense of well-being. It offers a useful perspective on the value of health care, especially for chronically disabling conditions, including chronic mental illness. At least three major quality-of-life outcome assessment frameworks are available: general quality of life, health-related quality of life, and disease-specific quality of life. Choice of a framework must be driven by the intent of the services. For persons with chronic, disabling conditions, a general quality-of-life perspective is most appropriate, one that accounts not only for direct health outcomes but also for the potential social and economic effects of medical disability.
SN - 0278-2715
AD - Center for Mental Health Services Research, University of Maryland School of Medicine, Baltimore, USA.
U2 - PMID: 7498907.
DO - 10.1377/hlthaff.14.3.90
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Files, Ashley
AU - Murray, Margaret
AD - US Public Health Service
AD - US Public Health Service
T1 - German Risk Structure Compensation: Enhancing Equity and Effectiveness
JO - Inquiry
JF - Inquiry
Y1 - 1995///Fall
VL - 32
IS - 3
SP - 300
EP - 309
SN - 00469580
N1 - Accession Number: 0371134; Geographic Descriptors: Germany; Geographic Region: Europe; Publication Type: Journal Article; Update Code: 199512
KW - Health: Government Policy; Regulation; Public Health I18
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Analysis of Health Care Markets I11
L3 - http://www.inquiryjournalonline.org/loi/inqr
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UR - http://www.inquiryjournalonline.org/loi/inqr
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 107356137
T1 - Need for nutrition advice in prenatal care.
AU - Yu SM
AU - Jackson RT
Y1 - 1995/09//
N1 - Accession Number: 107356137. Language: English. Entry Date: 19960101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Nutrition Education -- In Pregnancy
KW - Patient Education
KW - Prenatal Care
KW - Questionnaires
KW - Retrospective Design
KW - United States
KW - Pregnancy Outcomes
KW - Infant Mortality
KW - Infant, Newborn
KW - Infant
KW - Adult
KW - Middle Age
KW - Pregnancy
KW - Female
KW - Human
SP - 1027
EP - 1029
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 95
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md
U2 - PMID: 7657905.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107373257
T1 - Effects of homelessness on the quality of life of persons with severe mental illness.
AU - Lehman AF
AU - Kernan E
AU - DeForge BR
AU - Dixon L
Y1 - 1995/09//1995 Sep
N1 - Accession Number: 107373257. Language: English. Entry Date: 19960601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: structured Clinical Interview for DsM-III-R (SCID); Lehman Quality-of-Life Interview. Grant Information: Supported by grant R18-MH48070 from the Center for Mental Health Services Research and by the National Evaluation of the Robert Wood Johnson Program on Chronic Mental Illness. NLM UID: 9502838.
KW - Homeless Persons -- Psychosocial Factors
KW - Mental Disorders -- Psychosocial Factors
KW - Quality of Life
KW - Psychological Tests
KW - Comparative Studies
KW - Mental Disorders -- Diagnosis
KW - Socioeconomic Factors
KW - Funding Source
KW - Maryland
KW - Chi Square Test
KW - Logistic Regression
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 922
EP - 926
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 46
IS - 9
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Objective: This study assessed the relationship between homelessness and specific quality-of-life problems for persons with severe and persistent mental illness. Methods: The objective and subjective quality of life of 106 homeless persons with severe mental illness who lived on the streets or in shelters in Baltimore was compared with that of 146 domiciled persons with severe mental illness who lived in the community. Results: Objective and subjective quality of life of the homeless subjects was clearly worse than that of the domiciled group in the areas of living situation, family and social relations, employment, daily activities, and legal and safety problems. Homeless subjects were also less likely to have federal disability entitlements. Conclusions: Poorer quality of life is associated with homelessness among persons with severe mental illness. Their quality of life may be improved by efforts to increase their access to disability entitlements and treatment services and to help them develop supportive social networks.
SN - 1075-2730
AD - Center for Mental Health Services Research, Department of Psychiatry, School of Medicine, University of Maryland at Baltimore, 645 West Redwood Street, Baltimore, Maryland 21201
U2 - PMID: 7583504.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107373257&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107357655
T1 - Health policy. Get involved in national postmarketing surveillance.
AU - White GG
Y1 - 1995/09//1995 Sep
N1 - Accession Number: 107357655. Language: English. Entry Date: 19960201. Revision Date: 20150819. Publication Type: Journal Article; forms. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9508878.
KW - Mandatory Reporting
KW - Voluntary Reporting
KW - Product Surveillance
KW - Information Resources
KW - United States Food and Drug Administration
KW - Drugs
KW - Equipment and Supplies
KW - Documentation
SP - 44
EP - 51
JO - Surgical Services Management
JF - Surgical Services Management
JA - SURG SERV MANAGE
VL - 1
IS - 4
CY - Denver, Colorado
PB - Association of periOperative Registered Nurses
SN - 1079-8269
AD - US Food and Drug Administration, Rockville, Md
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107357655&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1996-22239-001
AN - 1996-22239-001
AU - Norfleet, William T.
AU - Coats, A. C.
AU - Powell, M. R.
T1 - Inverted immersion as a novel gravitoinertial environment.
JF - Aviation, Space, and Environmental Medicine
JO - Aviation, Space, and Environmental Medicine
JA - Aviat Space Environ Med
Y1 - 1995/09//
VL - 66
IS - 9, Section 1
SP - 825
EP - 828
CY - US
PB - Aerospace Medical Assn
SN - 0095-6562
N1 - Accession Number: 1996-22239-001. Other Journal Title: Aerospace Medicine; Aerospace Medicine and Human Performance. Partial author list: First Author & Affiliation: Norfleet, William T.; US Public Health Service, South East Alaska Regional Health Corp, Sitka, US. Release Date: 19960801. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Gravitational Effects; Motion Sickness; Spatial Orientation (Perception). Minor Descriptor: Motor Processes; Underwater Effects. Classification: Physiological Processes (2540). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 4. Issue Publication Date: Sep, 1995.
AB - Investigated inverted immersion (INI) and upright immersion (UI) as sources of motion sickness (MS) with 9 Ss exposed once to INI and UI. Throughout the experiment Ss' assembled a pipe puzzle, performed a series of head movements, and walked. Immediately postdive, postural stability was assessed with tandem standing with and without eyes closed and with and without the F neck extended 45°. A questionnaire regarding susceptibility to MS was completed predive. No S terminated the test because of MS during UI, while 7 Ss terminated the test during INI. Posture was less stable after INI than after UI sign test. MS questionnaire results did not predict susceptibility to INI. Result show INI is provocative of MS and postural instability. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - inverted immersion vs upright immersion
KW - motor processes & susceptibility to motion sickness
KW - 26–37 yr old male divers
KW - 1995
KW - Gravitational Effects
KW - Motion Sickness
KW - Spatial Orientation (Perception)
KW - Motor Processes
KW - Underwater Effects
KW - 1995
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Brown, David
T1 - Silicosis among Gold Miners: Exposure-Response Analyses and Risk Assessment.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/10//
VL - 85
IS - 10
M3 - Article
SP - 1372
EP - 1377
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study sought to estimate the risk of silicosis by cumulative exposure-years in cohort of miners exposed to silica as well as the lifetime risk of silicosis under the current. Occupational safety and Health Administration (OSHA) standard (0.09 mg/m³) Methods. In a cohort study of 3330 gold miners who worked at least 1 year undergone from 1940 to 1965 (average 9 years) and were exposed to a median silica level of 0.05 mg/m³ (0.15 mg/m³ for those hired before 1930), 170 cases of silicosis were determined form either death certificates or two crosssectional radiographic surveys. Results. The risk of silicosis was lessthan 1% with a cumulative exposure under 0.5 mg/m³ years. increasing to 68% to 84% for the highest cumulative exposures category of more than 4 mg/m³-years. Cumulative exposure was the best predictor of disease, followed by duration of exposure and average exposure. After adjustment for competing risks of death a 45-year exposure under the current OSHA standard would lead to a lifetime risk of silicosis of 35% to 47%. Conclusions. Almost 2 million US worker are currently exposed to silica. Our results add to a small but increasing body of literature that suggest that the current OSHA silica exposure level is unacceptably high. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Silicosis
KW - Lungs -- Dust diseases
KW - Miners
KW - Silica
N1 - Accession Number: 9510240233; Steenland, Kyle 1; Brown, David 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: National institute for Environmental Health Science Research Triangle Park, NC; Issue Info: Oct95, Vol. 85 Issue 10, p1372; Thesaurus Term: Occupational diseases; Subject Term: Silicosis; Subject Term: Lungs -- Dust diseases; Subject Term: Miners; Subject Term: Silica; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107427033
T1 - Special report: protection and advocacy: what nurses need to know... this paper was presented at the SERPN annual meeting in Rockville, MD, November 1994.
AU - Schauer C
Y1 - 1995/10//1995 Oct
N1 - Accession Number: 107427033. Language: English. Entry Date: 19951101. Revision Date: 20150819. Publication Type: Journal Article; proceedings. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8708535.
KW - Disabled
KW - Consumer Advocacy
KW - Psychiatric Nursing
KW - Patient Rights
KW - Nursing Role
KW - Mental Disorders, Chronic
KW - Government Programs -- United States
KW - Mental Health Services -- United States
KW - Public Assistance
KW - United States
KW - Disabled -- Legislation and Jurisprudence -- United States
KW - Legislation -- United States
KW - Civil Rights
SP - 233
EP - 239
JO - Archives of Psychiatric Nursing
JF - Archives of Psychiatric Nursing
JA - ARCH PSYCHIATR NURS
VL - 9
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - There is a national system of protection and advocacy programs for people with mental illness, developmental disabilities, and other disabilities. These programs investigate allegations of abuse and neglect and pursue legal, administrative, and other appropriate remedies to protect the rights of individuals with disabilities. Nurses have a critical role in advocating and protecting rights of consumers with psychiatric disabilities and identifying and reporting incidents of abuse and neglect. The unique role of the nurse within practice, research and education regarding protection and advocacy is discussed. Copyright (c) 1995 by W.B. Saunders Company
SN - 0883-9417
AD - Protection and Advocacy Program, Center for Mental Health Services, 5600 Fishers Lane, Room 15C-21, Rockville, MD 20857
U2 - PMID: 7487164.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107427033&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Johnston, Janet J.
T1 - Occupational Injury and Stress.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/10//
VL - 37
IS - 10
M3 - Article
SP - 1199
EP - 1203
SN - 00961736
AB - A literature search was conducted to identify studies that measured the relationship between stress and occupational injury. Studies that provided a quantitative measure of stress and occupational injury and a quantitative assessment of the relationship between these two factors were selected for this review. Twenty studies were identified, and all had P values of less than .05 or odds ratios ranging from .3 to 4.6. Twelve of 17 measures had odds ratios greater than 1.0. Several factors limit the generalizability of these results, however, and these include methodological differences in the assessment of stress and injury, study design, and limited representation of occupations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379769; Johnston, Janet J. 1; Source Information: Oct1995, Vol. 37 Issue 10, p1199; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107358443
T1 - Briefings. Thoughts and reflections after the bombing of the Alfred P. Murrah Federal Building in Oklahoma City.
AU - Flynn BW
Y1 - 1995/10//
N1 - Accession Number: 107358443. Language: English. Entry Date: 19960201. Revision Date: 20150711. Publication Type: Journal Article; anecdote. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9507418.
KW - Disasters -- Oklahoma
KW - Social Attitudes
KW - Rituals and Ceremonies
KW - Life Experiences
KW - Interpersonal Relations
KW - Oklahoma
KW - Symbolism (Psychology)
KW - Hope
SP - 166
EP - 170
JO - Journal of the American Psychiatric Nurses Association
JF - Journal of the American Psychiatric Nurses Association
JA - J AM PSYCHIATR NURSES ASSOC
VL - 1
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1078-3903
AD - Center for Mental Health Services, SAMHSA, Dept of Health and Human Services, 5600 Fishers Lane, Rm 16C-26, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baker, Karen H.
AU - Cygnarowicz-Provost, Miriam
T1 - WHAT YOU SHOULD KNOW ABOUT STERILIZED EQUIPMENT.
JO - Nursing
JF - Nursing
Y1 - 1995/10//
VL - 25
IS - 10
M3 - Article
SP - 21
EP - 21
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article presents suggestions to ensure that the medical devices are properly sterilized before performing a sterile procedure. Check the expiration date, load label, and internal and external chemical indicators of the medical device. Precautions must be taken when opening and handling sterile items. INSET: How it's done (sterilization methods)..
KW - MEDICAL equipment
KW - STERILIZATION (Disinfection)
KW - DISINFECTION & disinfectants
KW - BIOLOGICAL decontamination
KW - MEDICAL supplies
N1 - Accession Number: 9511074663; Baker, Karen H. 1; Cygnarowicz-Provost, Miriam 2; Source Information: Oct95, Vol. 25 Issue 10, p21; Subject: MEDICAL equipment; Subject: STERILIZATION (Disinfection); Subject: DISINFECTION & disinfectants; Subject: BIOLOGICAL decontamination; Subject: MEDICAL supplies; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107426471
T1 - Combating infection. What you should know about sterilized equipment.
AU - Baker KH
AU - Cygnarowicz-Provost M
Y1 - 1995/10//
N1 - Accession Number: 107426471. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Sterilization and Disinfection
KW - Infection Control
KW - Equipment Contamination -- Prevention and Control
SP - 21
EP - 21
JO - Nursing
JF - Nursing
JA - NURSING
VL - 25
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 7566707.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107426471&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107389707
T1 - Noise and hearing loss in firefighting.
AU - Tubbs RL
Y1 - 1995/10//1995 Oct-Dec
N1 - Accession Number: 107389707. Language: English. Entry Date: 19961101. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Firefighters
KW - Occupational Diseases
KW - Occupational Exposure
KW - Noise -- Adverse Effects
KW - Hearing Loss, Noise-Induced
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Audiometry
KW - National Institute for Occupational Safety and Health
KW - Surveys
KW - Research
SP - 843
EP - 856
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 10
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Since the NIH received a request to investigate the high degree of hearing loss in a fire department in 1980, hearing loss among firefighters has become an area of increased investigation. The author identified the sources of occupational noise in firefighting, looks at audiometric testing and recent research in firefighting noise, and presents guidelines for implementing hearing conservation programs.
SN - 0885-114X
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107254036
T1 - Trends of diarrheal disease--associated mortality in US children, 1968 through 1991.
AU - Kilgore PE
AU - Holman RC
AU - Clarke MJ
AU - Glass RI
AU - Kilgore, P E
AU - Holman, R C
AU - Clarke, M J
AU - Glass, R I
Y1 - 1995/10/11/
N1 - Accession Number: 107254036. Language: English. Entry Date: 19980401. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Diarrhea -- Mortality -- In Infancy and Childhood
KW - Diarrhea -- Trends -- In Infancy and Childhood
KW - Retrospective Design
KW - United States
KW - Infant
KW - Child, Preschool
KW - Human
SP - 1143
EP - 1148
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 274
IS - 14
CY - Chicago, Illinois
PB - American Medical Association
AB - Objectives: To describe temporal patterns in mortality related to diarrheal disease in US children and to assess progress toward its prevention and control.Design: Retrospective analyses of death certificate data on diarrhea of all causes compiled by the National Center for Health Statistics, Centers for Disease Control and Prevention, Atlanta, Ga.Patients: Children aged 1 month through 4 years who died with diarrhea.Setting: United States, 1968 through 1991.Results: A total of 14 137 deaths associated with diarrhea among children were reported in the United States between 1968 and 1991. Of these, 78% occurred in infants (ie, aged 1 to 11 months); the median age at the time of death has declined from 5 to 1.5 months. Diarrheal disease mortality dropped by approximately 75% during the first 18 years of the study, but no decline has occurred since 1985. Infant mortality due to diarrhea (per 100 000 live births) averaged 12.8 and was found to be high for blacks (33.1) and for residents of the southern United States (18.5). The infant mortality due to diarrhea from 1986 through 1991 is 5.9. Peaks in winter deaths previously associated with rotavirus were prominent in the early years among infants aged 4 through 11 months. Such peaks have virtually disappeared since 1985. Diarrhea was the principal cause of death, as the leading associated diagnoses (electrolyte disorders [30%], cardiac arrest [16%], shock [8%], and nausea/vomiting [4%]) were commonly recognized complications of diarrhea. Since 1979, prematurity has emerged as a common associated diagnosis.Conclusions: Diarrheal deaths nationwide have declined 75% from 1968 to 1985 but stabilized since then at about 300 deaths per year. Because many of these deaths may still be preventable by early rehydration, future prevention efforts should be directed at educating health care providers about the continuing problem and recognition of the high-risk infant and at teaching mothers of such infants to begin rehydration early and to seek medical attention when their infant develops diarrhea.
SN - 0098-7484
AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
AD - Viral Gastroenteritis Section, Mailstop G-04, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333
U2 - PMID: 7563485.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107254036&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107370121
T1 - Nutrition labeling: energy values of foods and fat substitutes. Proceedings of a symposium held in Beltsville, MD, May 8-11, 1994.
AU - Wiesenfeld PL
Y1 - 1995/11/02/Nov95 Supplement
N1 - Accession Number: 107370121. Language: English. Entry Date: 19960501. Revision Date: 20150819. Publication Type: Journal Article; proceedings. Supplement Title: Nov95 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Food Labeling -- Legislation and Jurisprudence
KW - Food Additives
KW - Energy Intake
KW - Consumer Product Safety
KW - United States Food and Drug Administration
KW - Legislation -- United States
KW - United States
KW - Government Regulations
SP - 1143S
EP - 6S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 62
CY - Bethesda, Maryland
PB - American Society for Nutrition
SN - 0002-9165
AD - Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708
U2 - PMID: 7484933.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107370121&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107148358
T1 - Body dissatisfaction and unhealthy weight-control practices among adolescents with and without chronic illness: a population-based study.
AU - Neumark-Sztainer D
AU - Story M
AU - Resnick MD
AU - Garwick A
AU - Blum RW
Y1 - 1995/12//
N1 - Accession Number: 107148358. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by Rehabilitation Research and Training Grant H133B40019 from the National Institute on Disability and Rehabilitative Research and grant MCJ273A0305 from the Maternal and Child Health Bureau, Rockville, MD. NLM UID: 9422751.
KW - Body Image -- In Adolescence
KW - Weight Control -- In Adolescence
KW - Chronic Disease -- In Adolescence
KW - Eating Disorders -- Epidemiology -- In Adolescence
KW - Survey Research
KW - Questionnaires
KW - Cluster Sample
KW - Self Report
KW - Chi Square Test
KW - Logistic Regression
KW - Odds Ratio
KW - Confidence Intervals
KW - P-Value
KW - Sex Factors
KW - Adolescence
KW - Male
KW - Female
KW - Funding Source
KW - Human
SP - 1330
EP - 1335
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 149
IS - 12
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - US Public Health Service, Division of General Pediatrics and Adolescent Health, Box 721, 420 Delaware St SE, University of Minnesota, Minneapolis, MN 55455
U2 - PMID: 7489069.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107148358&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Nelson, R. C.;
T1 - Regulatory issues related to clinical trials
CT - Regulatory issues related to clinical trials
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1995/12/01/
VL - 30
IS - Dec
SP - PI
EP - 13
AD - Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 32-13244; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Drug EvaluationsMethodology
N2 - Changes at the U.S. Food and Drug Administration (FDA) are profoundly affecting the new drug development process. Timeliness of New Drug Application (NDA) review is a continuing concern. Attempts to speed the process include expanding FDA staff, increased training, upgraded information handling systems at FDA, expedited approval schemes for drugs to treat life-threatening illnesses, and use of research methods other than the classic randomized, double blind, placebo controlled clinical trial. Additional initiatives to provide an efficient drug development path include use of large simple trials, surrogate markers for efficacy, and heterogenous study populations. FDA supports current efforts to increase international collaboration in drug development. Another important health initiative is to improve pediatric labeling by setting out mechanisms for deriving pediatric doses for marketed drugs as well as products in development. Learning objectives: 1. Identify advantages and disadvantages of a rapid drug development process. 2. Understand the difficulties and mechanisms for establishing pediatric doses for currently marketed products. 3. Describe the efforts underway to increase international collaboration in drug development. Self-assessment questions: 1. FDA is required to complete its review of a New Drug Application within 90 days of its submission. 2. Prior to 1995, manufacturers were not required to place pediatric dosing information in the labeling of new drug products brought to market. 3. The International Conference on Harmonization has resulted in regulatory changes in the drug development process in the United States. Answers: 1. (T), 2. (T), 3. (T).
KW - ASHP meeting abstracts--clinical studies, regulations;
KW - Food and Drug Administration (U.S.)--regulations--clinical studies;
KW - Clinical studies--regulations--FDA;
KW - Drugs, investigational--new drug applications--clinical studies;
KW - Regulations--clinical studies--FDA;
KW - Methodology--clinical studies--FDA attitudes;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Burke, L. B.;
T1 - Role of FDA in the regulation of pharmaceutical cost-effectiveness promotion
CT - Role of FDA in the regulation of pharmaceutical cost-effectiveness promotion
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1995/12/01/
VL - 30
IS - Dec
SP - PI
EP - 48
AD - Medical Practices and Communications Branch, Division of Drug Marketing, Advertising and Communications, Food and Drug Administration, HFD-246, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 32-13245; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and Ethics
N2 - Managed care organizations are concerned about rational therapeutics and cost-effective utilization of medications. The role of the pharmaceutical industry in providing information to support formulary decision-making and product utilization, however, raises a number of issues. To gain a broad perspective on the role of pharmaceutical industry marketing practices, the nature of information exchange in managed care environments, and the role of the FDA in regulating product promotion in managed care, the FDA hosted a one and one-half day hearing. The views of a range of affected constituencies will be presented to delineate specific concerns about the content and quality of promotional messages and practices. Learning objectives: 1. Name some of the constituencies involved in the generation of comparative effectiveness information. 2. Discuss the range of views that are held regarding the need for and the regulation of comparative effectiveness claims. 3. Describe the relevance of existing FDA policy for the regulation of comparative effectiveness claims to the range of views discussed in #2 above. Self-assessment questions: 1. FDA regulates the information distributed by managed care and other health care organizations. 2. FDA expertise in comparative effectiveness research is limited. 3. FDA recognizes the need to measure drug effectiveness in the real world. Answers: 1. False 2. False 3. True
KW - ASHP meeting abstracts--cost benefit, industry marketing;
KW - Drug comparisons--clinical studies--cost benefit marketing;
KW - Food and Drug Administration (U.S.)--regulations--cost benefit marketing;
KW - Regulations--Food and Drug Administration--cost benefit marketing;
KW - Pharmacoeconomics--cost benefit analysis--marketing;
KW - Economics--cost benefit analysis--marketing, industry;
KW - Industry, pharmaceutical--marketing--cost benefit claims;
KW - Marketing--industry, pharmaceutical--cost benefit claims;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13245&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Ludden, T. M.;
T1 - Sex related differences in the pharmacokinetics and dynamics of drugs
CT - Sex related differences in the pharmacokinetics and dynamics of drugs
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1995/12/01/
VL - 30
IS - Dec
SP - PI
EP - 11
AD - Division of Biopharmaceutics, Rm 13B06, HFD-420, 5600 Fishers Lane, Food and Drug Administration, Rockville, MD 20857, USA
N1 - Accession Number: 32-13194; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Drug Metabolism and Body Distribution; Pharmacology
N2 - Numerous physiologic and environmental factors may cause or contribute to sex related differences in pharmacokinetics and pharmacodynamics. While most gender related differences in drug disposition are relatively modest, examples of gender related differences in clearance of 100% or more do exist. Differences in efficacy and adverse effects between females and males are often reported for various psychotropic, cardiovascular and anti-inflammatory agents. The female life time is marked by distinct physiologic and pharmacologic variations such as the menstrual cycle, pregnancy, oral contraceptive therapy, menopause and hormone replacement therapy. Until recently, little attention has been given to how these factors impact pharmacokinetics and drug effects. Systematic research is needed to better define the importance of these factors. The result will be greater therapeutic benefit for both genders. Learning objectives: 1. List at least two drugs that exhibit large gender related differences in clearances. 2. Describe at least two possible drug-drug interactions that may occur with oral contraceptives. 3. Describe the need for studying gender related differences prior to phase 3 of new drug development. Self-assessment questions: 1. Name two drugs that exhibit 50-100 percent differences in clearance between genders. 2. Describe the effect of ethynyl type oral contraceptives on drug metabolism. 3. What adjustment in phenytoin dose may be needed during pregnancy? Answers: 1. (propranolol and tirilazad), 2. (suicide inhibitor), 3. (increase).
KW - ASHP meeting abstracts--pharmacokinetics, sex related differences;
KW - Pharmacokinetics--drugs--sex related differences;
KW - Blood levels--drugs--sex related differences;
KW - Pharmacodynamics--drugs--sex related differences;
KW - Sex--patients--pharmacokinetics;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13194&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Morris, L. A.;
T1 - When is a cost-effectiveness claim valid?
CT - When is a cost-effectiveness claim valid?
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1995/12/01/
VL - 30
IS - Dec
SP - PI
EP - 47
AD - Medical Practices and Communications Branch, Food and Drug Administration, HFD-246, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 32-13232; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Methodology; Legislation, Laws and RegulationsDrug Evaluations
N2 - The managed care promotional activities of the pharmaceutical industry can be evaluated in light of existing drug approval, labeling and advertising regulations. As the field of outcomes research and pharmacoeconomics has evolved, so has FDA's interpretation and understanding of the strengths and limitations of various comparative study designs. FDA is in the process of developing guidance for the regulation of comparative pharmacoeconomic claims. Criteria for the interpretation of comparative claim validity will be presented along with a discussion of regulatory concerns regarding cost-effectiveness and quality of life claims. Learning objectives: 1. Name some pitfalls in pharmacoeconomic study design and describe their relationship to the validity of comparative claims in drug promotion. 2. Discuss the interpretation of cost-effectiveness and quality of life claims in light of the current standards for claim substantiation. 3. Describe the application of existing FDA regulations to pharmacoeconomic promotion by the drug industry. Self-assessment questions: 1. A cost-effectiveness drug claim must be based on adequate and well controlled studies. 2. A quality of life claim must be measured with a validated quality of life instrument. 3. FDA regulations differentiate between efficacy and effectiveness. Answers: 1. True 2. True 3. False
KW - ASHP meeting abstracts--cost comparisons validity;
KW - Methodology--cost benefit analysis--validity;
KW - Clinical studies--cost benefit analysis--methodology;
KW - Guidelines--clinical studies--cost comparisons validity;
KW - Industry, pharmaceutical--clinical studies--cost comparisons validity;
KW - Food and Drug Administration (U.S.)--regulations--cost comparisons validity;
KW - Regulations--Food and Drug Administration--cost comparisons validity;
KW - Pharmacoeconomics--clinical studies--cost comparisons validity;
KW - Economics--cost benefit analysis--validity;
KW - Drug comparisons--costs--validity;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=32-13232&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Comas-Díaz, Lillian
AU - Jansen, Mary A.
T1 - Global Conflict and Violence Against Women.
JO - Peace & Conflict
JF - Peace & Conflict
Y1 - 1995/12//
VL - 1
IS - 4
M3 - Article
SP - 315
SN - 10781919
AB - Global and local conflicts often emerge due to sociopolitical changes. Many of these changes entail negative consequences to women, usually in the form of violence against them. This article describes some of the oppressive conditions of women living in technologically underdeveloped and developed countries, as well as in war and state-sponsored violence areas. Special attention is also given to the gender-specific violence experienced by refugee women. A review of women's reactions to oppression and violence suggests that many cope with their grief through creative transformation. Women's resistance movements and their contributions to the liberation and peace process embody female forms of empowerment. This article discusses feminine movements such as las madres (mothers), campesinas (peasants), Amazonas (Amazons), and arpilleras (women who make arpilleras--cloth pictures) as examples of female empowerment in the midst of violence. We conclude that women's resistance against violence has altered our discourse of culture, gender, and politics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Peace & Conflict is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN -- Social conditions
KW - WOMEN in politics
KW - WOMEN -- Crimes against
KW - VIOLENCE
KW - AGGRESSION (Psychology)
KW - GENDER
N1 - Accession Number: 7332207; Comas-Díaz, Lillian 1; Jansen, Mary A. 2; Affiliations: 1 : Transcultural Mental Health Institute, Washington, DC.; 2 : Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Washington, DC.; Source Info: 1995, Vol. 1 Issue 4, p315; Subject Term: WOMEN -- Social conditions; Subject Term: WOMEN in politics; Subject Term: WOMEN -- Crimes against; Subject Term: VIOLENCE; Subject Term: AGGRESSION (Psychology); Subject Term: GENDER; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
AU - Stout, Nancy A.
AU - Jenkins, E. Lynn
AU - Pizatella, Timothy J.
T1 - Occupational Injury Mortality Rates in the United States: Changes from 1980 to 1989.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/01//
VL - 86
IS - 1
M3 - Article
SP - 73
EP - 73
PB - American Public Health Association
SN - 00900036
AB - Changes in occupational injury mortality rates over the 1980s were examined through analysis of the National Traumatic Occupational Fatalities surveillance system. The US occupational injury mortality rate decreased 37% over the decade, with decreases seen in nearly every demographic and employment sector. Greater declines were among men, Blacks, and younger workers, as well as among agricultural, trade, and service workers. Electrocutions, machine-related incidents, and homicides showed the greatest decreases. Changes in occupational mortality rates by demography, industry, and cause of death indicate the areas in which the most progress has been made and those that are prime targets for prevention efforts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Mortality
KW - Homicide
KW - Death -- Causes
KW - Work-related injuries
N1 - Accession Number: 9602123524; Stout, Nancy A. 1; Jenkins, E. Lynn 1; Pizatella, Timothy J. 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV; Issue Info: Jan1996, Vol. 86 Issue 1, p73; Thesaurus Term: Industrial hygiene; Subject Term: Mortality; Subject Term: Homicide; Subject Term: Death -- Causes; Subject Term: Work-related injuries; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Britt, A L
T1 - Safety information processing at the FDA
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1996/01//Jan-Mar 1996
VL - 30
IS - 1
M3 - Article
SP - 47
EP - 58
SN - 00928615
AB - Adverse drug experience (ADE) information processing is a surveillance activity at the Food and Drug Administration (FDA) that monitors the safety of drugs after marketing. This paper is an overview of the spontaneous Adverse Drug Reaction Information System, postmarketing surveillance activities, and samples of summary reports used to identify safety issues.
KW - INFORMATION processing
KW - Biotechnology
KW - Drug information
KW - Federal government
N1 - Accession Number: ISTA3100861; Britt, A L 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: Jan-Mar 1996, Vol. 30 Issue 1, p47; Note: Update Code: 3100; Subject Term: INFORMATION processing; Author-Supplied Keyword: Biotechnology; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Federal government; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - SLIKKER, WILLIAM
AU - CRUMP, KENNY S.
AU - ANDERSON, MELVIN E.
AU - BELLINGER, DAVID
T1 - Biologically Based, Quantitative Risk Assessment of Neurotoxicants.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1996/01//
VL - 29
IS - 1
M3 - Article
SP - 18
EP - 30
PB - Oxford University Press / USA
SN - 02720590
AB - The need for biologically based, quantitative risk assessment procedures for noncancer endpoints such as neurotoxicity has been discussed in reports by the United States Congress (Office of Technology Assessment, OTA), National Research Council (NRC), and a federal coordinating council. According to OTA, current attention and resources allocated to health risk assessment research are inadequate and not commensurate with its impact on public health and the economy. Methods to include continuous rather than dichotomous data for neurotoxicity endpoints, biomarkers of exposure and effects, and pharmacokinetic and mechanistic data have been proposed for neurotoxicity risk assessment but require further review and validation before acceptance. The purpose of this symposium was to examine procedures to enhance the risk assessment process for neurotoxicants and to discuss techniques to make the process more quantitative. Accordingly, a review of the currently used safety factor risk assessment approach for neurotoxicants is provided along with specific examples of how this process may be enhanced with the use of the benchmark dose approach. The importance of including physiologically based pharmacokinetic data in the risk assessment process and specific examples of this approach is presented for neurotoxicants. The role of biomarkers of exposure and effect and mechanistic information in the risk assessment process are also addressed. Finally, quantitative approaches with the use of continuous neurotoxicity data are demonstrated and the outcomes compared to those generated by currently used risk assessment procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Neurotoxic agents
KW - Neurotoxicology
KW - Pharmacokinetics
KW - National Research Council (U.S.)
N1 - Accession Number: 82425508; SLIKKER, WILLIAM 1; CRUMP, KENNY S. 2; ANDERSON, MELVIN E. 3; BELLINGER, DAVID 4; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration Jefferson, Arkansas 72079; 2: † KS Crump, ICF Kaiser Engineers Ruston, Lousiana 71270; 3: ‡ ICF Kaiser, Crump Division Morrisville, North Carolina 27560; 4: § Neuroepidemiology Unit, Children's Hospital Harvard Medical School Boston, Massachusetts 02115; Issue Info: 1996, Vol. 29 Issue 1, p18; Thesaurus Term: Health risk assessment; Thesaurus Term: Neurotoxic agents; Subject Term: Neurotoxicology; Subject Term: Pharmacokinetics ; Company/Entity: National Research Council (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harkin, Timothy J.
AU - McGuinness, Georgeann
AU - Goldring, Roberta
AU - Cohen, Henry
AU - Parker, John E.
AU - Crane, Michael
AU - Naidich, David P.
AU - Rom, William N.
T1 - Differentiation of the ILO Boundary Chest Roentgenograph (0/1 to 1/0) in Asbestosis by High-Resolution Computed Tomography Scan, Alveolitis, and Respiratory Impairment.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/01//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - High-resolution computed tomography (HRCT) scans have been advocated as providing greater sensitivity in detecting parenchymal opacities in asbestos-exposed individuals, especially in the presence of pleural fibrosis, and having excellent inter- and intraobserver reader interpretation. We compared the 1980 International Labor Organization (ILO) International Classification of the Radiographs of the Pneumoconioses for asbestosis with the high-resolution CT scan using a grid scoring system to better differentiate normal versus abnormal in the ILO boundary 0/1 to 1/0 chest roentgenograph. We studied 37 asbestos-exposed individuals using the ILO classification, HRCT grid scores, respiratory symptom questionnaires, pulmonary function tests, and bronchoalveolar lavage. We used Pearson correlation coefficients to evaluate the linear relationship between outcome variables and each roentgenographic method. The normal HRCT scan proved to be an excellent predictor of "normality," with pulmonary function values close to 100% for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLCO) and no increase in BAL inflammatory cells. Concordant HRCT/ILO abnormalities were associated with reduced FEV1/FVC ratio, reduced diffusing capacity, and alveolitis consistent with a definition of asbestosis. In our study, the ILO classification and HRCT grid scores were both excellent modalities for the assessment of asbestosis and its association with impaired physiology and alveolitis, with their combined use providing statistical associations with alveolitis and reduced diffusing capacity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635105; Harkin, Timothy J. 1; McGuinness, Georgeann 1; Goldring, Roberta 1; Cohen, Henry 1; Parker, John E. 2; Crane, Michael; Naidich, David P.; Rom, William N. 1; Source Information: Jan1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4301
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Pratt, Stephanie G.
AU - Kisner, Suzanne M.
AU - Helmkamp, James C.
T1 - Machinery-Related Occupational Fatalities in the United States, 1980 to 1989.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/01//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - The National Traumatic Occupational Fatalities surveillance system identified machinery-related incidents as the second leading cause of traumatic occupational fatalities in the United States between 1980 and 1989. These incidents resulted in 8,505 civilian worker deaths and an average annual fatality rate of .80 per 100,000 workers. Workers aged 65 years and older had 5.8 times the fatality rate of workers aged 16 to 64 years (4.06 vs .70). The highest industry-specific rate was noted in agriculture, forestry, and fishing (7.47). Tractors and other agricultural machinery were associated with nearly 9 of every 10 fatal machinery-related incidents involving workers aged 65 or older. Although numerous studies of agricultural machinery-related fatalities are found in the literature, detailed analyses of machinery-related fatalities in the construction industry as well as analyses of work situations and risk factors associated with fatal injuries are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635108; Pratt, Stephanie G. 1; Kisner, Suzanne M. 1; Helmkamp, James C. 1; Source Information: Jan1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4466
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107360645
T1 - Rugged individualism and compassion: the foundation of public policy.
AU - Plotnick J
AU - Presler B
Y1 - 1996/01//1996 Jan-Feb
N1 - Accession Number: 107360645. Language: English. Entry Date: 19960301. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7605941.
KW - Individuality
KW - Public Policy
KW - Maternal-Child Nursing -- Trends
KW - Health Care Delivery -- Trends -- United States
KW - Medicaid
KW - Consumer Participation
KW - United States
KW - Political Participation
KW - Technology -- Trends
KW - Health Care Costs
SP - 20
EP - 33
JO - MCN: The American Journal of Maternal Child Nursing
JF - MCN: The American Journal of Maternal Child Nursing
JA - MCN
VL - 21
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Social policy affects funding for research and education, and shapes the practice arena. Knowledge of the values and trends influencing past policies gives us insight to prepare for the future.
SN - 0361-929X
AD - Chief Nurse Officer, US Public Health Service
U2 - PMID: 8825665.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 1996-98227-001
AN - 1996-98227-001
AU - Blumenthal, Susan J.
ED - Sechzer, Jeri A.
ED - Pfafflin, Sheila M.
ED - Denmark, Florence L.
ED - Griffin, Anne
ED - Blumenthal, Susan J.
ED - Sechzer, Jeri A., (Ed)
ED - Pfafflin, Sheila M., (Ed)
ED - Denmark, Florence L., (Ed)
ED - Griffin, Anne, (Ed)
ED - Blumenthal, Susan J., (Ed)
T1 - Women's mental health: The new national focus.
T2 - Women and mental health.
T3 - Annals of the New York Academy of Sciences; Vol 789; ISSN: 0077-8923 (Print)
Y1 - 1996///
VL - 789
SP - 1
EP - 16
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 0077-8923
SN - 1-57331-032-8
SN - 1-57331-033-6
N1 - Accession Number: 1996-98227-001. Partial author list: First Author & Affiliation: Blumenthal, Susan J.; US Dept of Health & Human Services, US Public Health Service, Washington, DC, US. Release Date: 19970201. Correction Date: 20150713. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-032-8, Hardcover; 1-57331-033-6, Paperback. Language: English. Major Descriptor: Disorders; Government Policy Making; Human Females. Minor Descriptor: Addiction; Biology; Environment; Etiology; Health Care Services; Human Sex Differences; Mental Disorders; Psychosocial Factors. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40). Intended Audience: Psychology: Professional & Research (PS). Page Count: 16.
AB - [argue that] the challenge to the mental health community is to better understand and better respond to the panoply of biological, environmental, and psychosocial factors that contribute to the etiology of mental and addictive disorders in women, given the long history of inequity in how medicine and science have approached women's health in the past / reviews the gender differences that exist in mental illness—in epidemiology, in research, and in treatment / [discusses] what the US Department of Health and Human Services and, in particular, the PHS [Public Health Service] Office on Women's Health are doing to increase knowledge and improve health care research and delivery for our nation's women, with a focus particularly on the mental and addictive disorders (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care & public policy issues & gender differences in & biological & environmental & psychosocial factors in etiology of mental & addictive disorders
KW - females
KW - 1996
KW - Disorders
KW - Government Policy Making
KW - Human Females
KW - Addiction
KW - Biology
KW - Environment
KW - Etiology
KW - Health Care Services
KW - Human Sex Differences
KW - Mental Disorders
KW - Psychosocial Factors
KW - 1996
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1996-98227-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2000-12131-003
AN - 2000-12131-003
AU - Tinker, Tim L.
T1 - Recommendations to improve health risk communication: Lessons learned from the U.S. Public Health Service.
JF - Journal of Health Communication
JO - Journal of Health Communication
JA - J Health Commun
Y1 - 1996/01//Jan-Mar, 1996
VL - 1
IS - 2
SP - 197
EP - 217
CY - United Kingdom
PB - Taylor & Francis
SN - 1081-0730
SN - 1087-0415
N1 - Accession Number: 2000-12131-003. PMID: 10947360 Partial author list: First Author & Affiliation: Tinker, Tim L.; U.S. Public Health Service, Centers for Disease Control & Prevention, Agency for Toxic Substances & Disease Registry, Atlanta, GA, US. Release Date: 20000920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Communication; Health Education; Public Health; Risk Management. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. Methodology: Empirical Study. Page Count: 21. Issue Publication Date: Jan-Mar, 1996.
AB - The growth in the public's concern over environmental health risks has placed new requirements and demands on U.S. Public Health Service (PHS) agencies for information that describes and explains the nature of risk in clear and comprehensible terms. Experience has shown, however, that merely disseminating information without reliance on communication principles can lead to ineffective health messages and public health actions. This article presents the findings of a study conducted by the Subcommittee on Risk Communication and Education of the Environmental Health Policy Committee (EHPC), PHS, on how PHS agencies are communicating information about health risk; how effective these communications have been; and what specific principles, strategies, and practices best promote effective health risk communication. The purpose of the Subcommittee's study was to develop specific recommendations that would help PHS decision makers and health risk communicators improve the effectiveness of health information provided to, and received from, the public. The study suggests fundamental principles drawn from a series of case studies from PHS agencies about how best to plan and carry out risk communication activities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recommendations to improve health risk information communication to the public
KW - US Public Health Service
KW - 1996
KW - Communication
KW - Health Education
KW - Public Health
KW - Risk Management
KW - 1996
DO - 10.1080/108107396128149
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2000-12131-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Sim, M. R.
AU - Echt, A.
T1 - An Outbreak of Pruritic Skin Lesions in a Group of Laboratory Workers—A Case Report.
JO - Occupational Medicine
JF - Occupational Medicine
Y1 - 1996/01/03/
VL - 46
IS - 3
M3 - Article
SP - 235
EP - 238
PB - Oxford University Press / USA
SN - 09627480
AB - In May 1993, an outbreak of pruritic skin lesions occurred among a group of employees located in tour laboratories in the basement of an office building. Medical interviews with the affected workers were performed and an industrial hygiene survey of the site was conducted. Workers commonly reported a prickling sensation on exposed skin. Four of the workers had small (<5mm) erythematous papules on their forearms. Just prior to the outbreak, the installation of fibrous glass insulation had commenced in the mechanical rooms which provided air to the basement of the building. Because of the nature of the symptoms and the temporal relationship with the nearby insulation work, direct skin contact with fibrous glass fibres was thought to be the cause of the outbreak. The poorly maintained air handling unit supplying air to the laboratories probably contributed to this outbreak by inefficient filtering of the circulating air. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Air filters
KW - Erythema -- Diagnosis
KW - Skin diseases
KW - Glass fibers
KW - Thermal insulation
KW - Forearm
KW - Dermatitis
KW - fibrous glass
KW - laboratory workers
N1 - Accession Number: 85722472; Sim, M. R. 1; Echt, A. 2; Affiliations: 1: Department of Epidemiology and Preventive Medicine, Monash University Melbourne, Australia; 2: Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health Cincinnati, Ohio, USA; Issue Info: 1996, Vol. 46 Issue 3, p235; Thesaurus Term: Industrial hygiene; Thesaurus Term: Air filters; Subject Term: Erythema -- Diagnosis; Subject Term: Skin diseases; Subject Term: Glass fibers; Subject Term: Thermal insulation; Subject Term: Forearm; Author-Supplied Keyword: Dermatitis; Author-Supplied Keyword: fibrous glass; Author-Supplied Keyword: laboratory workers; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 326193 Motor vehicle plastic parts manufacturing; NAICS/Industry Codes: 327212 Other Pressed and Blown Glass and Glassware Manufacturing; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 327993 Mineral Wool Manufacturing; NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 423330 Roofing, Siding, and Insulation Material Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Guerry, Patricia
AU - Doig, Peter
AU - Alm, Richard A.
AU - Burr, Donald H.
AU - Kinsella, Niamh
AU - Trust, Trevor J.
T1 - Identification and characterization of genes required for post-translational modification of Campylobacter coli VC167 flagellin.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1996/01/15/
VL - 19
IS - 2
M3 - Article
SP - 369
EP - 378
PB - Wiley-Blackwell
SN - 0950382X
AB - Two genes have been identified in Campylobacter coli VC167 which are required for the biosynthesis of post-translational modifications on flagellin proteins. The ptmA gene encodes a protein of predicted M r 28 486 which shows significant homology to a family of alcohol dehydrogenases from a variety of bacteria. The ptmB gene encodes a protein of predicted M r 26 598 with significant homology to CMP-N -acetylneuraminic acid synthetase enyzmes involved in sialic acid capsular biosynthesis in Neisseria meninigitidis and Escherichia coli K1. Site-specific mutation of either ptmA or ptmB caused loss of reactivity with antisera specific to the post-translational modifications and a change in the isoelectric focusing fingerprints relative to the parent strains. Mutation of ptmB , but not of ptmA , caused a change in apparent M r, of the flagellin subunit in SDS-PAGE gels. The ptmA and ptmB genes are present in other strains of Campylobacter . In a rabbit model the ptmA mutant showed a reduced ability to elicit protection against subsequent challenge with heterologous strains of the same Lior sero-type compared to the parental wild-type strain. This suggests that the surface-exposed post-translational modifications may play a significant role in the protective immune response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter
KW - Gram-negative bacterial diseases
KW - Genes
KW - Proteins
KW - Dehydrogenases
N1 - Accession Number: 21318447; Guerry, Patricia 1; Email Address: guerry_p@mail2.nmri.nnmc.navy.mil; Doig, Peter 2; Alm, Richard A. 2; Burr, Donald H. 1,3; Kinsella, Niamh 2; Trust, Trevor J. 2; Affiliations: 1: Enteric Diseases Program, Naval Medical Research Institute, Bethesda, Maryland 20889, USA; 2: Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada; 3: Food and Drug Administration, Washington, DC, USA; Issue Info: Jan1996, Vol. 19 Issue 2, p369; Thesaurus Term: Campylobacter; Thesaurus Term: Gram-negative bacterial diseases; Subject Term: Genes; Subject Term: Proteins; Subject Term: Dehydrogenases; Number of Pages: 10p; Illustrations: 5 Diagrams, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105852913
T1 - The interface between research and the diagnosis of an emerging tick-borne disease, human ehrlichiosis due to Ehrlichia chaffeensis.
AU - Dawson JE
AU - Warner CK
AU - Standaert S
AU - Olson JG
Y1 - 1996/01/22/
N1 - Accession Number: 105852913. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Bacteria
KW - Ehrlichiosis -- Diagnosis
KW - Ehrlichiosis -- Epidemiology
KW - Documentation
KW - Ehrlichiosis -- Drug Therapy
KW - Gram-Negative Bacteria
KW - Nucleotides
KW - Polymerase Chain Reaction
KW - Research
KW - United States
KW - Human
SP - 137
EP - 142
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 156
IS - 2
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Ga, USA.
U2 - PMID: 8546547.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Occupational Exposure to Chrysotile Asbestos and Cancer Risk: A Review of the Amphibole Hypothesis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 179
EP - 179
PB - American Public Health Association
SN - 00900036
AB - Objectives. This article examines the credibility and policy implications of the "amphibole hypothesis," which postulates that (1) the mesotheliomas observed among workers exposed to chrysotile asbestos may be explained by confounding exposures to amphiboles, and (2) chrysotile may have lower carcinogenic potency than amphiboles. Methods. A critical review was conducted of the lung burden, epidemiologic, toxicologic, and mechanistic studies that provide the basis for the amphibole hypothesis. Results. Mechanistic and lung burden studies do not provide convincing evidence for the amphibole hypothesis. Toxicologic and epidemiologic studies provide strong evidence that chrysotile is associated with an increased risk of lung cancer and mesothelioma. Chrysotile may be less potent than some amphiboles for inducing mesotheliomas, but there is little evidence to indicate lower lung cancer risk. conclusions. Given the evidence of a significant lung cancer risk, the lack of conclusive evidence for the amphibole hypothesis, and the fact that workers are generally exposed to a mixture of fibers, we conclude that it is prudent to treat chrysotile with virtually the same level of concern as the amphibole forms of asbestos. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestos
KW - Amphiboles
KW - Chrysotile
KW - Lungs -- Cancer
KW - Mesothelioma
N1 - Accession Number: 9603040361; Stayner, Leslie T. 1; Dankovic, David A. 1; Lemen, Richard A. 1; Affiliations: 1: Risk Assessment Program, Office of the Director, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Feb1996, Vol. 86 Issue 2, p179; Thesaurus Term: Asbestos; Subject Term: Amphiboles; Subject Term: Chrysotile; Subject Term: Lungs -- Cancer; Subject Term: Mesothelioma; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yu, Stella M.
AU - Keppel, Kenneth G.
AU - Singh, Gopal K.
AU - Kessel, Woodie
T1 - Preconceptional and Prenatal Multivitamin-Mineral Supplement Use in the 1998 National Maternal and Infant Health Survey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 240
EP - 240
PB - American Public Health Association
SN - 00900036
AB - This paper examines the prevalence of multivitamin-mineral supplement use before and during pregnancy, as well as predictors of nonuse, in 9953 women who delivered live infants in the 1988 National Maternal and Infant Health Survey. Ninety-seven percent of the women were advised to take multivitamin-mineral supplements in prenatal care. Sixty- seven percent of Black mothers took supplements during pregnancy, as compared with 84% of White mothers. Multivariate analysis revealed that Black mothers; mothers who are less educated, younger, unmarried, and non-smokers; and mothers who participate in Women, Infants, and Children programs are at elevated risk for nonuse. These data help identify groups in need of supplementation guidance. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Vitamins
KW - Pregnant women
KW - Pregnancy
KW - Infants
N1 - Accession Number: 9603040388; Yu, Stella M. 1; Keppel, Kenneth G. 2; Singh, Gopal K. 3; Kessel, Woodie 1; Affiliations: 1: Division of Science, Education and Analysis, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; 2: Division of Health Promotion Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md.; 3: Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md.; Issue Info: Feb1996, Vol. 86 Issue 2, p240; Thesaurus Term: Dietary supplements; Subject Term: Vitamins; Subject Term: Pregnant women; Subject Term: Pregnancy; Subject Term: Infants; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kahn, Laura H.
AU - Blustein, Jan
AU - Arons, Raymond R.
AU - Yee, Raymond
AU - Shea, Steven
T1 - The Validity of Hospital Administrative Data in Monitoring Variations in Breast Cancer Surgery.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 243
EP - 243
PB - American Public Health Association
SN - 00900036
AB - To assess the validity of using hospital administrative data to measure variations in surgery for early-stage breast cancer, ICD-9-CM coded information was compared with corresponding tumor registry data for 1293 breast cancer patients undergoing lumpectomy or mastectomy at a tertiary referral center from January 1989 to October 1993. Relative to "gold standard" tumor registry data, the administrative data proved 83.4% sensitive and 80.4% specific in identifying women with localized disease who would be potential candidates for lumpectomy. The proportion of women with localized disease under- going lumpectomy in groups defined by race and insurance status was nearly identical, whichever data were used. Administrative data, which is often readily and publicly available, may be useful in studying variations in breast cancer treatment in key demographic groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical records
KW - Breast cancer
KW - Oncologic surgery
KW - Tumors
KW - Lumpectomy
N1 - Accession Number: 9603040391; Kahn, Laura H. 1; Blustein, Jan 2,3; Arons, Raymond R. 3,4; Yee, Raymond 4; Shea, Steven 2,5; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration. Washington, DC; 2: Division of General Medicine, Columbia College of Physicians and Surgeons, New York, NY; 3: Division of Health Policy and Management, School of Public Health, Columbia University; 4: Office of Case Mix Studies, Presbyterian Hospital, New York, NY; 5: Division of Epidemiology, School of Public Health, Columbia University; Issue Info: Feb1996, Vol. 86 Issue 2, p243; Subject Term: Medical records; Subject Term: Breast cancer; Subject Term: Oncologic surgery; Subject Term: Tumors; Subject Term: Lumpectomy; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Alston, P G
T1 - Environment online. Update '95
JO - Database Magazine
JF - Database Magazine
Y1 - 1996/02//Feb-Mar 1996
VL - 19
IS - 1
M3 - Article
SP - 32
EP - 34;
SN - 01624105
AB - This article focuses on the growth of environmental information that occurred during 1995 on the Internet. The author provides a comprehensive overview of electronic sources of environmental information available via the Internet, including private databases, government-related information, and international information.
KW - DATABASES
KW - INTERNET
KW - Environmental information
KW - Online systems
N1 - Accession Number: ISTA3100798; Alston, P G 1; Affiliations: 1 : ATSDR Public Health Service, Atlanta, GA; Source Info: Feb-Mar 1996, Vol. 19 Issue 1, p32; Note: Update Code: 3100; Subject Term: DATABASES; Subject Term: INTERNET; Author-Supplied Keyword: Environmental information; Author-Supplied Keyword: Online systems; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - WOLFF, GEORGE L.
T1 - Variability in Gene Expression and Tumor Formation within Genetically Homogeneously Animal Populations in Bioassays1.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1996/02//
VL - 29
IS - 2
M3 - Article
SP - 176
EP - 184
PB - Oxford University Press / USA
SN - 02720590
AB - Considerable variation in susceptibility to tissue-specific tumor formation in response to chronic treatment with low or intermediate dose levels of putative carcinogens is observed within populations of genetically homogeneous test animals under controlled environmental conditions. Experimental evidence from National Toxicology Program studies is reviewed, as are studies of differing degrees of carcinogenic response and tumor promotion among iso- and congenic mice carrying the Avy (viable yellow) mutation. The data suggest that individual variations in carcinogenic response among genetically homogeneous animals may derive primarily from differences in regulation of gene transcription. Differences in posttranscriptional and posttranslational processing of gene products are probably also contributing factors. The viable yellow Avy/a mouse model system is uniquely suited for investigating the developmental and molecular bases of this phenotypic variability in genetically homogeneous populations since various degrees of carcinogenic response and promotion of tumor formation can be predicted, a priori, at least as early as 7 days of age by correlation with coat color patterns. Ectopic expression of the agouti protein results in enhanced susceptibility to tumor formation in tissues which are already sensitized to neoplastic transformation by their strain genome. The differences in tumorigenic response and coat color pattern among Avy/– mice appear to be associated with different DNA methylation states of the promoter of an intracisternal A particle inserted into exon 1A of the agouti gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animal population genetics
KW - Biological assay
KW - Animal genetics
KW - Enzyme bioassay
KW - Phenotype -- Physiological aspects
KW - DNA methylation
N1 - Accession Number: 82425483; WOLFF, GEORGE L. 1; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, U.S. Department of Health and Human Services Jefferson, Arkansas 72079 and Departments of Biochemistry/Molecular Biology and Pharmacology/Toxicology University of Arkansas for Medical Sciences Little Rock, Arkansas 72205; Issue Info: 1996, Vol. 29 Issue 2, p176; Thesaurus Term: Animal population genetics; Thesaurus Term: Biological assay; Subject Term: Animal genetics; Subject Term: Enzyme bioassay; Subject Term: Phenotype -- Physiological aspects; Subject Term: DNA methylation; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GREENMAN, DAVID L.
AU - MORRISSEY, ROBERT L.
AU - BLAKEMORE, WILLIAM
AU - CROWELL, JAMES
AU - SIITONEN, PAUL
AU - FELTON, PAUL
AU - ALLEN, RICHARD
AU - CRONIN, GERALD
T1 - Subchronic Toxicity of Triethylenetetramine Dihydrochloride in B6C3F1 Mice and F344 Rats.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1996/02//
VL - 29
IS - 2
M3 - Article
SP - 185
EP - 193
PB - Oxford University Press / USA
SN - 02720590
AB - Triethylenetetramine dihydrochloride (trien-2HCl; CAS No. 38260-01-04), a chelating agent used to treat Wilson's disease patients who are intolerant of the drug of choice, was tested for subchronic toxicity in B6C3F1 mice and F344 rats. Mice and rats received trien-2HCl in the drinking water at concentrations of 0, 120, 600, or 3000 ppm for up to 92 days. Twenty mice and 18 rats of each sex were assigned to each dose group fed either a cereal-based (NIH-31) or a purified (AIN-76A) diet, both containing nutritionally adequate levels of copper. An additional control group of rats and mice received a Cu-deficient AIN-76A diet. This low copper diet resulted in Cu-deficiency symptoms, such as anemia, liver periportal cytomegaly, pancreatic atrophy and multifocal necrosis, spleen hematopoietic cell proliferation, and increased heart weight, together with undetectable levels of plasma copper in rats but not in mice. Trien-2HCl lowered plasma copper levels somewhat (at 600 and 3000 ppm) in rats fed the AIN-76A diet, but did not induce the usual signs of copper deficiency. Trien-2HCl caused an increased frequency of uterine dilatation at 3000 ppm in rats fed AIN-76A diet that was not noted in females fed the Cu-deficient diet. Trien-2HCl toxicity occurred only in mice in the highest dose group fed an AIN-76A diet. Increased frequencies of inflammation of the lung interstitium and liver periportal fatty infiltration were seen in both sexes, and hematopoietic cell proliferation was seen in the spleen of males. Kidney and body weights were reduced in males as was the incidence of renal cytoplasmic vacuolization. There were no signs of copper deficiency in mice exposed to trien-2HCl. The only effect of trien-2HCl in animals fed the NIH-31 diet was a reduced liver copper level in both rat sexes, noted at 3000 ppm. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Triethylenetetramine
KW - Poisons -- Physiological effect
KW - Copper -- Physiological effect
KW - Anemia -- Genetic aspects
KW - Cell proliferation -- Physiological aspects
KW - Atrophy -- Risk factors
KW - Rats -- Physiological aspects
N1 - Accession Number: 82425484; GREENMAN, DAVID L. 1,2; MORRISSEY, ROBERT L. 3; BLAKEMORE, WILLIAM 4; CROWELL, JAMES 3; SIITONEN, PAUL 4; FELTON, PAUL 3; ALLEN, RICHARD 5; CRONIN, GERALD 2; Affiliations: 1: Office of Associate Director for Scientific Coordination, National Center for Toxicological Research 3900 NCTR Road, Jefferson, Arkansas 72079; 2: † Division of Nutritional Toxicology, National Center for Toxicological Research 3900 NCTR Road, Jefferson, Arkansas 72079; 3: ‡ Pathology Associates, Inc., National Center for Toxicological Research 3900 NCTR Road, Jefferson, Arkansas 72079; 4: § Division of Chemistry, National Center for Toxicological Research 3900 NCTR Road, Jefferson, Arkansas 72079; 5: System Development Corporation, National Center for Toxicological Research 3900 NCTR Road, Jefferson, Arkansas 72079; Issue Info: 1996, Vol. 29 Issue 2, p185; Subject Term: Triethylenetetramine; Subject Term: Poisons -- Physiological effect; Subject Term: Copper -- Physiological effect; Subject Term: Anemia -- Genetic aspects; Subject Term: Cell proliferation -- Physiological aspects; Subject Term: Atrophy -- Risk factors; Subject Term: Rats -- Physiological aspects; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Proctor, Enola K.
AU - Morrow-Howell, Nancy
AU - Kaplan, Salley J.
T1 - Implementation of Discharge Plans for Chronically Ill Elders Discharged Home.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1996/02//
VL - 21
IS - 1
M3 - Article
SP - 30
EP - 30
PB - Oxford University Press / USA
SN - 03607283
AB - Although discharge plans are viewed as the primary means to ensure that patients' needs will be met in the posthospital environment, little is known about the implementation of arranged care. This study addressed the extent to which discharge plans for elderly patients with congestive heart failure were implemented as planned, tested the consequences of implementation problems, and identified factors associated with implementation problems. For 40 percent of patients, one or more components of the discharge plan were not implemented as planned, with discrepancies more likely among low-income patients. Implementation discrepancies had negative consequences in terms of unmet needs, deficient quantity of help, and less than adequate care. Implications for hospital discharge planners and home health care are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health & Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH facilities -- Discharge planning
KW - OLDER people -- Health
KW - CHRONICALLY ill
KW - HEART failure
KW - HOME care services
KW - MEDICAL care
KW - adequacy of care
KW - CONGESTIVE HEART FAILURE
KW - discharge planning
KW - elderly people
KW - home health care
KW - informal care
KW - INSTITUTIONAL AND NONINSTITUTIONAL CARE
KW - PROGRAM IMPLEMENTATION
N1 - Accession Number: 9602154233; Proctor, Enola K. 1,2; Morrow-Howell, Nancy 3; Kaplan, Salley J. 4; Source Information: Feb1996, Vol. 21 Issue 1, p30; Subject: HEALTH facilities -- Discharge planning; Subject: OLDER people -- Health; Subject: CHRONICALLY ill; Subject: HEART failure; Subject: HOME care services; Subject: MEDICAL care; Author-Supplied Keyword: adequacy of care; Author-Supplied Keyword: CONGESTIVE HEART FAILURE; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: home health care; Author-Supplied Keyword: informal care; Author-Supplied Keyword: INSTITUTIONAL AND NONINSTITUTIONAL CARE; Author-Supplied Keyword: PROGRAM IMPLEMENTATION; Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article; Full Text Word Count: 7030
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hankinson, John L.
AU - Kinsley, Kathleen B.
AU - Wagner, Gregory R.
T1 - Comparison of Spirometric Reference Values for Caucasian and African American Blue-Collar Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/02//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - Interpretation of lung-function test results, specifically the forced vital capacity and forced expiratory volume in one second, generally involves the comparison of these parameters with reference values based on an individual's age, height, sex, and race. Such comparisons are often used to make important decisions concerning an individual, such as job placement or disability rating. Several studies[1,2,3] have shown that predicted values for African Americans are approximately 15% less than those for Caucasians, most likely because of the use of standing height to estimate the size of the thorax. When an adjustment for race is applied to reference values based on a Caucasian population, a single value (15%) is usually applied to all individuals.[4,5] When using a group of blue-collar workers (766 Caucasian and 633 African-American subjects) without any race adjustment, 10.2% of the Caucasians and 37.4% of the African-American subjects were below the lower limit of normal. When a single adjustment factor was used, 11.5% of the African-American subjects were below the lower limit of normal. Between-subject variability within an ethnic group was far greater than variability between groups. Our results suggest that although a difference between Caucasian and African-American test results for forced vital capacity and forced expiratory volume in one second exists, an application of a single adjustment factor universally applied to all individuals, regardless of their age, sex, and height, is not optimal, and alternative approaches are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635128; Hankinson, John L. 1; Kinsley, Kathleen B. 1; Wagner, Gregory R. 1; Source Information: Feb1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 3076
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ER -
TY - JOUR
AU - Razzaghi, Mehdi
AU - Gaylor, David W.
T1 - On the Correlation Coefficient Between the TD[sub50] and the MTD.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1996/02//
VL - 16
IS - 1
M3 - Article
SP - 107
EP - 113
SN - 02724332
AB - The existence of correlation between the carcinogenic potency and the maximum tolerated dose has been the subject of many investigations in recent years. Several attempts have been made to quantify this correlation in different bioassay experiments. By using some distributional assumptions, Krewski et al.[sup(1)] derive an analytic expression for the coefficient of correlation between the carcinogenic potency TD[sub50] and the maximum tolerated dose. Here, we discuss the deviation that may result in using their analytical expression. By taking a more general approach we derive an expression for the correlation coefficient which includes the result of Krewski el al.[sup(1)] as a special case, and show that their expression may overestimate the correlation in some instances and yet underestimate the correlation in other instances. The proposed method is illustrated by application to a real dataset. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Biological assay
KW - Carcinogenicity
KW - Correlation (Statistics)
KW - Probability theory
KW - Regression analysis
KW - carcinogen bioassay
KW - Carcinogenic potency
KW - correlation coefficient
KW - maximum tolerated dose
KW - toxicity.
N1 - Accession Number: 11762724; Razzaghi, Mehdi 1; Gaylor, David W. 2; Affiliations: 1: Bloomsburg University and National Center for Toxicological Research.; 2: National Center for Toxicological Research, Food and Drug Administration.; Issue Info: Feb96, Vol. 16 Issue 1, p107; Thesaurus Term: Carcinogens; Thesaurus Term: Biological assay; Thesaurus Term: Carcinogenicity; Subject Term: Correlation (Statistics); Subject Term: Probability theory; Subject Term: Regression analysis; Author-Supplied Keyword: carcinogen bioassay; Author-Supplied Keyword: Carcinogenic potency; Author-Supplied Keyword: correlation coefficient; Author-Supplied Keyword: maximum tolerated dose; Author-Supplied Keyword: toxicity.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Molzon, J. A.;
T1 - Generic drug approval process
CT - Generic drug approval process
JO - APhA Annual Meeting
JF - APhA Annual Meeting
Y1 - 1996/03/01/
VL - 143
IS - Mar
SP - 111
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
N1 - Accession Number: 33-08283; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations
N2 - This paper will help answer the question, Are generic drugs just as good as brand names? To address the issues involved, the regulatory history of generic drugs will be outlined, the approval process of an abbreviated new drug application (ANDA) will be detailed, and the determination of bioequivalence will be discussed. The paper will emphasize recent legal challenges and court decisions in the areas of bioequivalence. The requirement of exhausting administrative remedies will be explained via the petitions submitted under 21 CFR Section 10.30. This increased use of these petitions to challenge the actions by the Food and Drug Administration in the area of bioequivalence determination will be expounded upon. It should be noted that the views expressed in this paper are those of the author and do not necessarily represent the views of the Food and Drug Administration.
KW - Drugs--generic--approvals;
KW - Drugs--approvals--generics;
KW - Regulations--generic drugs--approvals;
KW - APhA meeting abstracts--generic drug approvals;
KW - Food and Drug Administration (U.S.)--regulations--generic drugs;
KW - Drugs, investigational--abbreviated new drug applications--generic drugs;
KW - Equivalency, generic--regulations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 104789408
T1 - Specific detection of Salmonella enterica serotype Enteritidis using the polymerase chain reaction.
AU - Lampel, K A
AU - Keasler, S P
AU - Hanes, D E
Y1 - 1996/03//
N1 - Accession Number: 104789408. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Food Microbiology
KW - Polymerase Chain Reaction -- Methods
KW - Salmonella
KW - Animal Studies
KW - DNA Probes
KW - Documentation
KW - Human
KW - Meat -- Microbiology
KW - Nucleotides
KW - Poultry -- Microbiology
KW - Sensitivity and Specificity
SP - 137
EP - 145
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 116
IS - 2
PB - Cambridge University Press
AB - An assay was developed for the specific detection of Salmonella enterica serotype Enteritidis, using a novel application of the polymerase chain reaction (PCR). This PCR assay is based on the mismatch amplification mutation assay, an allele-specific reaction, and can discriminate Enteritidis from all other salmonella. PCR primers were selected to amplify a 351-base pair (bp) DNA fragment from the salmonella plasmid virulence A (spv A) gene of Enteritidis. A single base difference at position 272 is present between the nucleotide sequence of the spvA gene of Enteritidis and other salmonellae. The downstream PCR primer, that encompasses position 272 of the Enteritidis spvA gene, was designed to contain a single base mismatch at the penultimate position, resulting in a 1-base mismatch with Enteritidis and a 2-base mismatch with other salmonellae that harbour the virulence plasmid. The upstream primer was completely homologous with the region immediately 5' to the spvA gene. When these primers were used and the annealing and extension reactions were performed at the same temperature, the PCR assay was specific for Enteritidis; no PCR product was detected for 40 other serotypes and 28 different genera examined. In pure culture, 120 colony forming units (c.f.u.) could be detected; a PCR product was observed from template derived from a 5 h enrichment broth culture of chicken seeded with 1 c.f.u. per gram of Enteritidis. This PCR assay is specific, reproducible, and less time consuming than the standard bacteriological methods used to detect Enteritidis.
SN - 0950-2688
AD - Division of Molecular Biological Research and Evaluation, U.S. Food and Drug Administration, Washington, D.C. 20204, USA.
U2 - PMID: 8620904.
DO - 10.1017/S0950268800052365
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ER -
TY - JOUR
AU - DEBORD, D. GAYLE
AU - CHEEVER, KENNETH L.
AU - WERREN, DWIGHT M.
AU - REID, THOMAS M.
AU - SWEARENGIN, TERRI F.
AU - SAVAGE, RUSSELL E.
T1 - Determination of 4,4′-Methylene-bis(2-chloroaniline)-DNA Adduct Formation in Rat Liver and Human Uroepithelial Cells by the 32P Postlabeling Assay1.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1996/03//
VL - 30
IS - 1
M3 - Article
SP - 138
EP - 144
PB - Oxford University Press / USA
SN - 02720590
AB - The probable human carcinogen 4,4′-methylene-bis(2-chloroaniline) (MOCA) was utilized to develop biomarkers of exposure to occupational carcinogens. The 32P postlabeling assay, utilizing the nuclease P1 enhancement procedure, was used to evaluate MOCA-DNA adduct formation in target tissues. Male Sprague-Dawley rats were treated with different dosing regimens of MOCA, and DNA was isolated from the liver. Additionally, a human uroepithelial cell (HUC) line was treated with N-hydroxy MOCA for 24 hr, cells were harvested, and DNA was isolated. DNA was analyzed for MOCA-DNA adduct formation by the 32P postlabeling assay. Five MOCA adducts were detected in rat liver DNA. Adduct A, which corresponded to N-(deoxyadenosin-8-yl)-4-amino-3-chlorobenzyl alcohol, was the major adduct in rat liver DNA appearing in all treatment groups. Levels of adduct A were higher when MOCA was administered by ip injection versus oral gavage. Phenobarbital pretreatment increased the amount of adduct A approximately 12-fold. The pathway leading to the formation of adduct A in DNA from HUC appeared to be saturated at the concentrations used: 2.5, 5, and 10 µM. However, an additional adduct (E) was observed at the 10 µM treatment level only. A major DNA adduct was detected in the target tissue of rats and target human cells for MOCA-induced carcinogenesis, thus making it useful as a biomarker of exposure. Other DNA adducts were also observed with the different doses and routes of exposure investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carbenes (Methylene compounds)
KW - Chloroaniline
KW - Carcinogens
KW - Biochemical markers
KW - DNA adducts
KW - Deoxyadenosine
KW - Rats as laboratory animals
N1 - Accession Number: 82419669; DEBORD, D. GAYLE 1; CHEEVER, KENNETH L. 1; WERREN, DWIGHT M. 1; REID, THOMAS M. 1; SWEARENGIN, TERRI F. 1; SAVAGE, RUSSELL E. 1; Affiliations: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science 4676 Columbia Parkway, Cincinnati, Ohio 45226; Issue Info: 1996, Vol. 30 Issue 1, p138; Thesaurus Term: Carbenes (Methylene compounds); Thesaurus Term: Chloroaniline; Thesaurus Term: Carcinogens; Thesaurus Term: Biochemical markers; Subject Term: DNA adducts; Subject Term: Deoxyadenosine; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DB - eih
ER -
TY - JOUR
ID - 107367181
T1 - The role of understaffing in central venous catheter-associated bloodstream infection.
AU - Fridkin SK
AU - Pear SM
AU - Williamson TH
AU - Galgiani JN
AU - Jarvis WR
Y1 - 1996/03//1996 Mar
N1 - Accession Number: 107367181. Language: English. Entry Date: 19960501. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Catheter-Related Infections -- Nursing
KW - Cross Infection -- Epidemiology
KW - Understaffing
KW - Bacteremia
KW - Catheters, Vascular
KW - Hospitals, Veterans
KW - Intensive Care Units
KW - Infection Control
KW - Arizona
KW - Epidemiological Research
KW - Risk Factors
KW - Disease Outbreaks
KW - Case Control Studies
KW - Prospective Studies
KW - Total Parenteral Nutrition
KW - Centers for Disease Control and Prevention (U.S.)
KW - Data Analysis Software
KW - Fisher's Exact Test
KW - Chi Square Test
KW - Middle Age
KW - Aged
KW - Inpatients
KW - Male
KW - Odds Ratio
KW - Confidence Intervals
KW - T-Tests
KW - Wilcoxon Rank Sum Test
KW - Logistic Regression
KW - Spearman's Rank Correlation Coefficient
KW - Multivariate Analysis
KW - Human
SP - 150
EP - 158
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 17
IS - 3
PB - Cambridge University Press
AB - OBJECTIVE: To determine risk factors for central venous catheter-associated bloodstream infections (CVC-BSI) during a protracted outbreak. DESIGN: Case-control and cohort studies of surgical intensive care unit (SICU) patients. SETTING: A university-affiliated Veterans Affairs medical center. PATIENTS: Case-control study: all patients who developed a CVC-BSI during the outbreak period (January 1992 through September 1993) and randomly selected controls. Cohort study: all SICU patients during the study period (January 1991 through September 1993). MEASUREMENTS: CVC-BSI or site infection rates, SICU patient clinical data, and average monthly SICU patient-to-nurse ratio. RESULTS: When analyzed by hospital location and site, only CVC-BSI in the SICU had increased significantly in the outbreak period compared to the previous year (January 1991 through December 1991: pre-outbreak period). In SICU patients, CVC-BSI were associated with receipt of total parenteral nutrition [TPN]; odds ratio, 16; 95% confidence interval, 4 to 73). When we controlled for TPN use, CVC-BSI were associated with increasing severity of illness and days on assisted ventilation. SICU patients in the outbreak period had shorter SICU and hospital stays, were younger, and had similar mortality rates, but received more TPN compared with patients in the pre-outbreak period. Furthermore, the patient-to-nurse ratio significantly increased in the outbreak compared with the pre-outbreak period. When we controlled for TPN use, assisted ventilation, and the period of hospitalization, the patient-to-nurse ratio was an independent risk factor for CVC-BSI in SICU patients. CONCLUSIONS: Nursing staff reductions below a critical level, during a period of increased TPN use, may have contributed to the increase in CVC-BSI in the SICU by making adequate catheter care difficult. During healthcare reforms and hospital downsizing, the effect of staffing reductions on patient outcome (ie, nosocomial infection) needs to be critically assessed.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia
U2 - PMID: 8708352.
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DB - rzh
ER -
TY - JOUR
AU - Shults, Ruth A.
AU - Baron, Sherry
AU - Decker, John
AU - Deitchman, Scott D.
AU - Connor, James D.
T1 - Health Care Worker Exposure to Aerosolized Ribavirin.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/03//
M3 - Article
SP - 257
EP - 263
SN - 00961736
AB - Aerosolized ribavirin is administered frequently to treat severe respiratory syncytial virus infections. The drug's potential reproductive effects in occupationally exposed workers remains a concern among health care workers. In this evaluation, we measured urinary ribavirin concentrations in occupationally exposed health care workers. Ribavirin was detected in 16 of 26 (62%) post-work-shift urine samples that had been provided by nurses, and in five of 22 (23%) post-work-shift urine samples that had been provided by respiratory therapists (range, <0.01 to 0.22 µmol/L). We also measured airborne ribavirin concentrations in the personal breathing zones of nurses. Ventilators and other administration units that were enclosed by an aerosol containment tent produced significantly lower airborne ribavirin exposures than administration units without a containment tent did (range, <2.5 to 78 µg/m3). On the basis of this and other evaluations of airborne ribavirin concentrations, we recommend using aerosol containment systems with all types of ribavirin administration units except mechanical ventilators. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379730; Shults, Ruth A. 1; Baron, Sherry 1; Decker, John 1; Deitchman, Scott D. 1; Connor, James D. 1; Source Information: Mar1996, p257; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3997
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DB - hch
ER -
TY - JOUR
AU - Banks, Daniel E.
AU - Wang, Mei-Lin
AU - McCabe, Lloyd
AU - Billie, Michael
AU - Hankinson, John
T1 - Improvement in Lung Function Measurements Using a Flow Spirometer that Emphasizes Computer Assessment of Test Quality.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/03//
M3 - Article
SP - 279
EP - 283
SN - 00961736
AB - We compared retrospective measurements of lung function from 101 steel workers using a commercially available spirometer to prospective lung function measurements performed, on average, 1.3 years later, with a newly developed spirometer. This spirometer was designed and developed to incorporate technology that provides immediate feedback on the quantitative and qualitative aspects of each forced expiratory effort. Of the 101 workers, 82 who had spirometry performed with each spirometer had at least two acceptable curves, and 51 workers tested with each spirometer had curves that met all American Thoracic Society (ATS) criteria for spirometry. No group showed the anticipated decline in forced expiratory volume in 1 second (FEV1) over time. The results showed an increased number of curves meeting ATS acceptability and reproducibility criteria, and a statistically significant increase in the FVC in all groups, and an increase in the FEV1 in the group encompassing all workers. Use of technology that strengthens the interaction between the spirometry technician, the data available to the technician on the computer, and the participant appears to represent true underlying lung function more accurately. Such an approach to the collection of lung function data should be considered by those evaluating spirometers for implementation in the workplace or pulmonary function laboratory as well as by those planning future spirometer development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379733; Banks, Daniel E. 1; Wang, Mei-Lin 1; McCabe, Lloyd 1; Billie, Michael 1; Hankinson, John 1; Source Information: Mar1996, p279; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 3242
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DB - hch
ER -
TY - JOUR
AU - Levy, Alan S.
AU - Fein, Sara B.
AU - Schucker, Raymond E.
T1 - Performance characteristics of seven nutrition label formats.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1996///Spring96
VL - 15
IS - 1
M3 - Article
SP - 1
EP - 15
PB - American Marketing Association
SN - 07439156
AB - The authors evaluate seven nutrition label formats to determine consumer comprehension and acceptance of displayed information. They test comprehension on five tasks: comparing two products, judging healthfulness, verifying claims, estimating servings needed to meet the daily requirement for a nutrient, and balancing nutrients in a daily diet. Performance scores were higher on some tasks-particularly dietary management ones-for formats that displayed nutrient amounts in percentages than for those that displayed nutrient amounts in metric units, even when interpretational aids were included on the metric formats. The two most preferred formats were metric formats with an interpretational aid. The findings have an important impact on decisions about the final nutrition label format required by the Food and Drug Administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food labeling
KW - Nutrition
KW - Consumer education
KW - Diet
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 9606054105; Levy, Alan S. 1; Fein, Sara B. 2; Schucker, Raymond E. 3; Affiliations: 1: Chief of the Consumer Studies Branch.; 2: Consumer Science Specialist, Consumer Studies Branch.; 3: Director, Division of Market Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration.; Issue Info: Spring96, Vol. 15 Issue 1, p1; Subject Term: Food labeling; Subject Term: Nutrition; Subject Term: Consumer education; Subject Term: Diet; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 15p; Illustrations: 7 Black and White Photographs, 5 Charts; Document Type: Article; Full Text Word Count: 9760
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DB - ufh
ER -
TY - JOUR
T1 - Human immunodeficiency virus-1 - tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.
AU - Dhawan, S.
AU - Puri, R. K.
AU - Ashok Kumar
AU - Duplan, H.
AU - Masson, J. M.
AU - Aggarwal, B. B.
JO - Blood
JF - Blood
Y1 - 1997///
VL - 90
IS - 4
SP - 1535
EP - 1544
SN - 0006-4971
AD - Dhawan, S.: Laboratory of Immunochemistry, Division of Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food And Drug Administration, Bethesda, MD, USA Correspondence address [Aggarwal, B. B.]: Cytokine Research Section, Department of Molecular Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
N1 - Accession Number: 19972009647. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 308079-78-9.
N2 - These results show that treatment of endothelial cells (EC) with HIV-Tat induces the cell surface expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1 in a time and dose-dependent manner. Cycloheximide abolished the HIV-Tat-dependent induction of all the adhesion molecules, indicating that protein synthesis was required for induction. The effect of HIV-Tat on expression of adhesion molecules was potentiated by tumour necrosis factor (TNF), a well known inducer of adhesion molecules. Like TNF, HIV-Tat also enhanced the adhesion of human promyelomonocytic HL60 cells to EC, and this effect was abolished by treatment with antibodies either against HIV-Tat or adhesion molecules. These results thus indicate that the HIV-Tat protein can activate human vascular EC to induce the expression of various adhesion molecules that may play a role in the extravasation of HIV-infected cells.
KW - adhesion
KW - antibodies
KW - cells
KW - effects
KW - endothelium
KW - HIV-1 infections
KW - human diseases
KW - human immunodeficiency viruses
KW - microbiology
KW - pathogenesis
KW - protein synthesis
KW - proteins
KW - regulatory genes
KW - surface proteins
KW - synthesis
KW - tat gene
KW - treatment
KW - tumour necrosis factor
KW - Human immunodeficiency virus 1
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - cachectin
KW - cachexin
KW - endothelial cells
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - membrane proteins
KW - protein biosynthesis
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DB - lhh
ER -
TY - JOUR
T1 - Final regulations for the nutrition labeling of raw fruits, vegetables, and fish.
AU - Pennington, J. A. T.
AU - Wilkening, V. L.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1997///
VL - 97
IS - 11
SP - 1299
EP - 1305
SN - 0002-8223
AD - Pennington, J. A. T.: Food and Drug Administration, Washington DC, USA.
N1 - Accession Number: 19981413854. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - This paper describes the US Food and Drug Administration voluntary programme for nutrition labelling based on the 1996 final rule and provides the revised nutrition labelling values for the 20 most frequently consumed raw fruits, vegetables and fish.
KW - fish
KW - foods
KW - fruit
KW - labelling
KW - nutrition
KW - regulations
KW - vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - rules
KW - United States of America
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Laws and Regulations (DD500)
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DB - lhh
ER -
TY - JOUR
T1 - The complicated task of monitoring vaccine safety.
AU - Ellenberg, S. S.
AU - Chen, R. T.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1997///
VL - 112
IS - 1
SP - 10
EP - 20
SN - 0033-3549
AD - Ellenberg, S. S.: Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA.
N1 - Accession Number: 19972007408. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Public Health
N2 - Vaccine safety topics are discussed and the Vaccine Adverse Event Reporting System (VAERS), initiated in 1990 in the USA and managed jointly by the Food and Drug Administration and the Centers for Disease Control and Prevention, is described.
KW - adverse effects
KW - bacterial diseases
KW - human diseases
KW - immunization
KW - safety
KW - surveillance
KW - vaccines
KW - viral diseases
KW - North America
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - adverse reactions
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972007408&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Profile of raw milk consumers in California.
AU - Headrick, M. L.
AU - Timbo, B.
AU - Klontz, K. C.
AU - Werner, S. B.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1997///
VL - 112
IS - 5
SP - 418
EP - 422
SN - 0033-3549
AD - Headrick, M. L.: Center for Food Safety and Applied Nutrition, Food and Drug Administration (FDA), 200 C St. SW, Washington DC 20204, USA.
N1 - Accession Number: 19970404314. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - The prevalence of raw milk consumption was determined in California - the largest producer of certified raw milk in the US - and the demographic and behavioural characteristics of raw milk consumers in that state were described. Responses to questions on the 1994 California Behavioral Risk Factor Surveillance System Survey that asked respondents about whether they drank raw milk, the amount consumed, the reason for drinking raw milk, and where raw milk was most often obtained, were analysed. Among 3999 survey respondents, 3.2% reported drinking raw milk in the previous year. Raw milk drinkers were more likely than non-drinkers to be <40 years old, male, and Hispanic and to have less than a high school education. It is concluded that raw milk continues to be consumed by some residents of California despite the documented hazards associated with this dietary practice. Information on the potential hazards of raw milk consumption should be targeted at the Hispanic population.
KW - age
KW - education
KW - ethnic groups
KW - intake
KW - men
KW - milk consumption
KW - raw milk
KW - sex differences
KW - women
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970404314&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food restriction reduces aflatoxin B1 (AFB1)-DNA adduct formation, AFB1-glutathione conjugation, and DNA damage in AFB1-treated male F344 rats and B6C3F1 mice.
AU - Chou, M. W.
AU - Chen Wen
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1997///
VL - 127
IS - 2
SP - 210
EP - 217
SN - 0022-3166
AD - Chou, M. W.: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971404443. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-49-2, 70-18-8. Subject Subsets: Human Nutrition
N2 - Weanling male B6C3F1 mice (16 weeks old; aflatoxin B1 (AFB1)-resistant) and Fischer 344 rats (10 weeks old; AFB1-sensitive) were housed individually and fed ad libitum (AL) or on 60% of AL (food restriction; FR). FR decreased the metabolic activation of AFB1 in rats and mice, decreasing the formation of hepatic AFB1-DNA adducts by 43 and 31%, respectively. The AFB1-DNA adduct, 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) was predominantly formed in rat liver DNA; the formation of the ring-open analogue of AFB1-N7-Gua, AFB1-formamidopyrimidine, was predominantly found in mouse liver DNA. In contrast to the in vivo results, the in vitro AFB1-DNA adduct formation mediated by the microsomes of liver, kidney or lung from FR-mice was greater than the formation of AFB1-DNA adducts mediated by the tissue microsomes from the AL-mice. FR induced hepatic glutathione S-transferase (GST) activity, as estimated by the formation of AFB1-glutathione conjugates (AFB1-SG), in rats and mice; AFB1-SG were also formed in mouse kidney. FR-induced GST activity assayed in an in vitro system, using [³H]AFB1-8,9-epoxide and glutathione as substrates, was also found when mouse kidney and lung cytosolic fractions were used. FR inhibited the AFB1-induced DNA double strand breaks in mouse kidney. The decrease in AFB1-DNA adduct formation in mouse kidney was comparable with the degree of AFB1-induced DNA strand breakages. Results indicate that the metabolic activation of AFB1 can be modulated by FR through the alteration of the formation of AFB1-DNA adducts and AFB1-SG conjugation. However, species and tissue specificities exist regarding the metabolic activation of AFB1.
KW - activity
KW - aflatoxins
KW - carcinogenesis
KW - damage
KW - dna
KW - enzymes
KW - food restriction
KW - glutathione
KW - kidneys
KW - liver
KW - lungs
KW - metabolism
KW - mycotoxins
KW - risk
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - fungal toxins
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971404443&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Obesity: common symptom of diverse gene-based metabolic dysregulations.
A2 - Wolff, G. L.
T2 - Journal of Nutrition
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1997///
VL - 127
IS - 9S
SP - 1867
EP - 1922
SN - 0022-3166
AD - Correspondence address: National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 19981414387. Publication Type: Conference proceedings. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition
N2 - The proceedings, consisting of an overview and 10 papers, of a conference entitled "Obesity: common symptom of diverse gene-based metabolic dysregulations" held in Little Rock, Arkansas, USA on March 4 1997 are presented. The aim of the conference was to familiarise physicians and basic researchers with recent developments in research on the genetic basis of obesity.
KW - genetics
KW - nutrition research
KW - obesity
KW - physicians
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - doctors
KW - fatness
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414387&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary nucleotides: effects on cell proliferation following partial hepatectomy in rats fed NIH-31, AIN-76A, or folate/methyl-deficient diets.
AU - Jackson, C. D.
AU - Weis, C.
AU - Miller, B. J.
AU - James, S. J.
A2 - Beck, M. A. et al.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1997///
VL - 127
IS - 5SUPPL
SP - 834S
EP - 837S
SN - 0022-3166
AD - Jackson, C. D.: Division of Nutritional Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19971408501. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 34 ref. Registry Number: 62-49-7, 59-30-3, 63-68-3, 63231-63-0. Subject Subsets: Human Nutrition
N2 - Hepatocyte proliferation following partial hepatectomy was examined in weanling male Fischer-344 rats fed on a natural ingredient NIH-31 diet, a nucleotide-free purified AIN-76A diet or a diet similar to AIN-76A but deficient in the methyl donors folate, choline and methionine. Additional groups were fed AIN-76A or folate/methyl-deficient diets supplemented with 0.25% yeast RNA. Compared with NIH-31, AIN-76A increased dUMP/dTTP ratios, reduced the mitotic index (MI) and increased the ratio of proliferating cell index (PCI) to mitotic cells, an indication that hepatocytes were delayed in S-phase. Addition of yeast RNA to AIN-76A reversed (by ~50%) the effects of AIN-76A on dUMP/dTTP and cell proliferation. A folate/methyl-deficient diet also produced and increased dUMP/dTTP ratio and markedly reduced the MI, increasing the PCI/IMI, suggesting even further delay of the cells in S-phase. It was concluded that addition of yeast RNA to the folate/methyl-deficient diet was effective in significantly reversing the effects of folate/methyl deficiency.
KW - choline
KW - diets
KW - folic acid
KW - growth
KW - hepatectomy
KW - intake
KW - liver cells
KW - methionine
KW - nucleotides
KW - rna
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - American Society for Nutritional Sciences annual meeting
KW - folacin
KW - folate
KW - hepatocytes
KW - liver removal
KW - ribonucleic acid
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971408501&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Descriptive epidemiology of adverse events after immunization: reports to the Vaccine Adverse Event Reporting System (VAERS), 1991-1994.
AU - Braun, M. M.
AU - Ellenberg, S. S.
JO - Journal of Pediatrics
JF - Journal of Pediatrics
Y1 - 1997///
VL - 131
IS - 4
SP - 529
EP - 535
SN - 0022-3476
AD - Braun, M. M.: Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 19982003528. Publication Type: Journal Article; Annual report; Journal article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - VAERS is a national surveillance system administered by the Food and Drug Administration and the Centers for Disease Control and Prevention in the USA. During the period 1991-94 a total of 38 787 adverse events was reported, with the total annual number of reports being distributed fairly evenly throughout this period. The number of vaccine-related deaths reported in 1991 was 167, in 1992 was 167, in 1993 was 206 and in 1994 was 159. Of the deaths where age was known, 72.4% were during the first year of life (63.7% of these male). A peak number of deaths was observed in those aged 1-3 months with a gradual decline through age 9 months; after this age death was relatively rare. It is suggested that this peak was due to incidence of sudden infant death syndrome not associated with vaccination. In 45.5% of the total reports adverse events occurred on the day of vaccination and in 20.4% symptoms occurred the following day; onset within 2 weeks of vaccination was noted in 92.5% of all reports. For immunizations at ages <20 years, simultaneous administration of multiple vaccines was recorded in 75.7% of reports, while in those aged ≥20 years only 6% of reports noted multiple vaccines.
KW - adverse effects
KW - age
KW - data collection
KW - epidemiology
KW - human diseases
KW - immunization
KW - incidence
KW - infectious diseases
KW - sudden infant death syndrome
KW - surveillance
KW - vaccination
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - communicable diseases
KW - cot death
KW - data logging
KW - immune sensitization
KW - SIDS
KW - sudden infant death
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982003528&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toward an integrated approach to molecular epidemiology.
AU - Ambrosone, C. B.
AU - Kadlubar, F. F.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 1997///
VL - 146
IS - 11
SP - 912
EP - 918
SN - 0002-9262
AD - Ambrosone, C. B.: National Center for Toxicological Research, Division of Molecular Epidemiology, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 19982004064. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - This commentary gives an overview of some of the prevailing attitudes toward molecular epidemiology, with the aim of identifying areas of concern and suggesting means of achieving harmonization. The role of molecular epidemiology in the understanding of disease is considered, including the identification of: susceptible subgroups in the population, aetiological agents in carcinogenesis and aetiological agents by characterization of DNA adducts. The need for cross-training of epidemiologists and laboratory scientists is discussed and suggestions are made for building successful collaborative relations across disciplines.
KW - epidemiology
KW - genetics
KW - human diseases
KW - methodology
KW - molecular epidemiology
KW - reviews
KW - trends
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - methods
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004064&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Maintenance of chemoprophylaxis against Pneumocystis carinii despite combination antiretroviral treatment associated CD4+ T-lymphocytosis.
AU - Macher, A. M.
AU - Goosby, E. P.
T2 - American Journal of Respiratory and Critical Care Medicine
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
Y1 - 1997///
VL - 155
IS - 4
SP - 1491
EP - 1491
SN - 1073-449X
AD - Macher, A. M.: Division of HIV Services, US Public Health Service, Rockville, MD, USA.
N1 - Accession Number: 19971201216. Publication Type: Correspondence. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The discontinuation of P. carinii pneumonia (PCP) chemoprophylaxis in HIV-positive patients receiving combination antiretroviral therapy whose CD4+ T-lymphocyte counts have risen to >0.300 × 109/litre is discussed. It is suggested that although these patients have CD4+ counts >0.200 × 109/litre, it is not known whether these CD4+ lymphocytes are qualitatively functional and can suppress PCP. Continuation of PCP prophylaxis in these patients is recommended, despite their elevated CD4+ counts.
KW - acquired immune deficiency syndrome
KW - chemoprophylaxis
KW - combination therapy
KW - drug therapy
KW - hiv infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - infections
KW - lungs
KW - opportunistic infections
KW - Pneumocystis carinii pneumonia
KW - pneumocystosis
KW - pneumonia
KW - predisposition
KW - prophylaxis
KW - proteinase inhibitors
KW - treatment
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - Pneumocystis
KW - Pneumocystidaceae
KW - AIDS
KW - chemotherapy
KW - combined modality therapy
KW - fungus
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - multimodal treatment
KW - other aspects
KW - protease inhibitors
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971201216&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chaparral-associated hepatotoxicity.
AU - Sheikh, N. M.
AU - Philen, R. M.
AU - Love, L. A.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 1997///
VL - 157
IS - 8
SP - 913
EP - 919
SN - 0003-9926
AD - Sheikh, N. M.: Clinical Research and Review Staff, Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St SW, HFS-452, Washington, DC 20204, USA.
N1 - Accession Number: 19981404217. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Horticultural Science
N2 - A total of 18 case reports of adverse events associated with the ingestion of chaparral (Larrea tridentata), a botanical dietary supplement, reported to the U.S. Food and Drug Administration (FDA) by health care professionals, state health departments and individual consumers between 1992 and 1994, were reviewed. 13 of 18 reports showed evidence of hepatotoxicity. Symptoms included fatigue, abdominal pain, dark urine, light stools, nausea and diarrhoea. Clinical presentation, characterized as jaundice with a marked increase in serum liver-associated enzymes, occurred 3-52 weeks after the ingestion of chaparral and resolved 1-17 weeks after most individuals stopped their intake of chaparral. The predominant pattern of liver injury was characterized as toxic or drug-induced cholestatic hepatitis; in 4 individuals there was progression to cirrhosis and in 2 individuals there was acute fulminant liver failure that required liver transplants. The majority of adverse events reported to the FDA were associated with single-ingredient chaparral capsules or tablets. It is concluded that the use of chaparral may be associated with acute to chronic irreversible liver damage with fulminant hepatic failure.
KW - adverse effects
KW - cirrhosis
KW - diarrhoea
KW - fatigue
KW - hepatitis
KW - jaundice
KW - liver
KW - liver failure
KW - nausea
KW - supplements
KW - symptoms
KW - toxicity
KW - USA
KW - Larrea tridentata
KW - Larrea
KW - Zygophyllaceae
KW - Sapindales
KW - Geraniales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - diarrhea
KW - icterus
KW - liver cirrhosis
KW - scouring
KW - tiredness
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Plant Science (General) (FF000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981404217&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A novel role for B cells in early protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.
AU - Culkin, S. J.
AU - Rhinehart-Jones, T.
AU - Elkins, K. L.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1997///
VL - 158
IS - 7
SP - 3277
EP - 3284
SN - 0022-1767
AD - Culkin, S. J.: Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, 1401 Rockville Pike HFM 431, Rockville, MD 20852, USA.
N1 - Accession Number: 19970504483. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9008-11-1. Subject Subsets: Medical & Veterinary Entomology
N2 - Normal BALB/cByJ mice given a sublethal infection of F. tularensis strain LVS survived 106 LD50s of lethal challenge given only 3 days later. The cell types responsible for this very strong early protective immunity were determined. Early protection was observed in athymic nu/nu mice but not fully immunodeficient scid mice, implicating a lymphocyte in this response. Using scid mice that were reconstituted with various purified cell subpopulations, as well as mice with genetically targeted disruptions in lymphocyte subpopulations (knockout mice), it was demonstrated that strong early protection is highly dependent on B cells. This protective mechanism, which limits bacterial growth in the organs of the reticuloendothelial system very quickly after infection, requires IFN-γ but is unlikely to involve specific antibody.
KW - B lymphocytes
KW - immune response
KW - immunity
KW - interferon
KW - laboratory animals
KW - tularaemia
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - B cells
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - nude mice
KW - tularemia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970504483&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression.
AU - Lafrenie, R. M.
AU - Wahl, L. M.
AU - Epstein, J. S.
AU - Yamada, K. M.
AU - Dhawan, S.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1997///
VL - 159
IS - 8
SP - 4077
EP - 4083
SN - 0022-1767
AD - Lafrenie, R. M.: Latoratory of Immunochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-315, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19972010656. Publication Type: Journal Article. Language: English. Number of References: 55 ref.
N2 - Treatment of primary monocytes with soluble HIV-Tat protein is associated with increased monocyte metalloproteinase-9 (MMP-9) expression and enhanced β2 integrin expression that increases monocyte/endothelial adhesion. These alterations require greater than 12 h of HIV-Tat treatment, suggesting the involvement of intermediate factors. Treatment of monocytes with HIV-Tat rapidly upregulated the production of IL-1β,IL-6, IL-8, and TNF-α, but not IL-3, granulocyte-macrophage CSF, basic fibroblast growth factor, or macrophage-inflammatory protein 1α, and was associated with up-regulation of the corresponding cytokine mRNA. The effects of HIV-Tat treatment, namely MMP-9 production, enhanced monocyte/endothelial cell adhesion, and monocyte-dependent endothelial damage, were mimicked by treating the monocytes with IL-1β or TNF-α, but not with IL-6 or IL-8. Therefore, the mechanism by which HIV-Tat activates monocyte function is dependent on HIV-Tat-induced production of cytokines (IL-1β and TNF-α).
KW - antigens
KW - cytokines
KW - endothelium
KW - HIV-1 infections
KW - human diseases
KW - immunopathology
KW - monocytes
KW - pathogenesis
KW - Tat protein
KW - treatment
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - antigenicity
KW - HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
KW - immunogens
KW - immunopathogenesis
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010656&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans.
AU - Oravecz, T.
AU - Pall, M.
AU - Wang JinHai
AU - Roderiquez, G.
AU - Ditto, M.
AU - Norcross, M. A.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1997///
VL - 159
IS - 9
SP - 4587
EP - 4592
SN - 0022-1767
AD - Oravecz, T.: Division of Hematologic Products, Center for Biologics Evaluation and Research, FDA, NIH, Bldg 29B, Rm 4E12, HFM-541, Bethesda, MD 20892, USA.
N1 - Accession Number: 19982000179. Publication Type: Journal Article. Language: English. Number of References: 34 ref.
N2 - The role of cell surface proteoglycans in CC chemokine-mediated anti-HIV-1 activity in T cells and macrophages was investigated. Enzyme digestion of heparan sulfate (HS), but not chondroitin sulfate, from the surface of PM1CD26H cells (a human T cell line selected for high CD26 expression) rendered them resistant to the antiviral effects of RANTES and macrophage inflammatory protein-1β at otherwise inhibitory chemokine concentrations. HIV-1 infection of macrophages, however, was inhibited only partially, even at high concentrations of RANTES, and this inhibition was not prevented by HS removal. Flow cytometry revealed that digestion of cell surface proteoglycans, including HS, prevented the binding of RANTES at 10 to 100 nM concentrations to PM1CD26H cells. However, the binding of RANTES to activated macrophages occurred only at higher concentrations (100-300 nM) and was mostly chondroitin sulfate, and not HS, dependent. These results support a role for HS in facilitating the interaction of CC chemokines with the cell surface and the consequent inhibition of HIV-1 infection. The absence of HS-dependent binding of RANTES at lower concentrations to macrophages is consistent with the resistance of these cells to the antiviral effects of chemokines.
KW - activity
KW - antiviral agents
KW - antiviral properties
KW - binding
KW - cell lines
KW - chemokines
KW - concentration
KW - cytokines
KW - flow cytometry
KW - human diseases
KW - immune response
KW - infection
KW - inhibition
KW - interactions
KW - macrophage activation
KW - macrophages
KW - proteins
KW - proteoglycans
KW - resistance
KW - surface proteins
KW - T lymphocytes
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - anti-viral properties
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - membrane proteins
KW - T cells
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Outbreaks of paralytic poliomyelitis, 1976-1995.
AU - Patriarca, P. A.
AU - Sutter, R. W.
AU - Oostvogel, P. M.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1997///
VL - 175
IS - Suppl. 1
SP - S165
EP - S172
SN - 0022-1899
AD - Patriarca, P. A.: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20852, USA.
N1 - Accession Number: 19972003623. Publication Type: Journal Article. Language: English. Number of References: 114 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - During 1976-1995, 48 outbreaks of paralytic poliomyelitis with a cumulative total of ~17 000 cases were reported worldwide. Outbreaks occurred on most continents, affected from 0.1 to 52 persons per 100 000 total population (median, 4.4), lasted 2-25 months (median, 7), typically involved unvaccinated or inadequately vaccinated subgroups within highly immunized communities, and were primarily caused by poliovirus type 1 (74%). Cases in developing countries occurred predominantly among children <2 years of age, while those in industrialized countries tended to occur in older persons who had escaped natural infection earlier in life and who had not been vaccinated or had received poliovirus vaccine of inadequate potency. Partial genomic sequencing studies indicated that at least 15 outbreaks resulted from importation of wild polioviruses, primarily from the Indian subcontinent. These findings illustrate the potential for wide dissemination of wild poliovirus infection and underscore the critical need for maintaining high levels of immunity in all countries and for more aggressive vaccination efforts in areas in which polio is endemic.
KW - children
KW - epidemiology
KW - human diseases
KW - immunity
KW - outbreaks
KW - paralysis
KW - poliomyelitis
KW - populations
KW - vaccination
KW - world
KW - Developing Countries
KW - Industrial Countries
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - countries
KW - Developed Countries
KW - human poliovirus
KW - polio
KW - Third World
KW - Underdeveloped Countries
KW - worldwide
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972003623&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viral interleukin-10 in chronic active Epstein-Barr virus infection.
AU - Kanegane, H.
AU - Wakiguchi, H.
AU - Kanegane, C.
AU - Kurashige, T.
AU - Tosato, G.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1997///
VL - 176
IS - 1
SP - 254
EP - 257
SN - 0022-1899
AD - Kanegane, H.: Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 19982000330. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - Viral interleukin-10 (IL-10), a product of the Epstein-Barr virus (EBV) replication gene BCRF1, shares extensive structural and functional similarity with the human cytokine IL-10. Both viral and human IL-10 inhibit T cell growth and interferon-γ production. With two ELISAs, one that recognized both human and viral (total) IL-10 and the other specific for viral IL-10, IL-10 was measured in serum or plasma from 34 patients in Japan with chronic active EBV infection (CAEBV) and from 15 healthy controls. Of the patients, 56% had measurable total IL-10 and 29% had measurable viral IL-10. In contrast, total IL-10 was detectable in only 2 of 15 controls and viral IL-10 was undetectable. Thus, many patients with CAEBV have abnormally high levels of circulating IL-10 that may contribute to disease pathogenesis by inhibiting host immunity.
KW - chronic infections
KW - cytokines
KW - human diseases
KW - immunopathology
KW - patients
KW - shares
KW - T lymphocytes
KW - viral diseases
KW - Japan
KW - Human herpesvirus 4
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Lymphocryptovirus
KW - Gammaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human herpesvirus 4
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Epstein-Barr virus
KW - immunopathogenesis
KW - T cells
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000330&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influenza pandemic preparedness plan for the United States.
AU - Patriarca, P. A.
AU - Cox, N. J.
A2 - Monto, A. S.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1997///
VL - 176
IS - Suppl. 1
SP - S4
EP - S7
SN - 0022-1899
AD - Patriarca, P. A.: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, MD 20852, USA.
N1 - Accession Number: 19982000382. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - A general account is given of the current plan being developed in the USA in preparation for the next influenza pandemic. The account covers a brief history of influenza pandemics and the strategies needed for preparedness including detection and warning, vaccine development, production and availability, vaccine utilization and coverage, and influenza-related research.
KW - disease control
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - influenza
KW - influenza viruses
KW - viral diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - flu
KW - Influenzavirus
KW - pandemics
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982000382&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53.
AU - Kinney, R. M.
AU - Butrapet, S.
AU - Chang GwongJen J.
AU - Tsuchiya, K. R.
AU - Roehrig, J. T.
AU - Bhamarapravati, N.
AU - Gubler, D. J.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1997///
VL - 230
IS - 2
SP - 300
EP - 308
SN - 0042-6822
AD - Kinney, R. M.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19970501481. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The GenBank accession numbers for the new nucleotide sequences are U87411 and U87412.
KW - arboviruses
KW - cell lines
KW - clones
KW - complementary dna
KW - mutations
KW - nucleotide sequences
KW - vaccines
KW - virulence
KW - Aedes albopictus
KW - Culicidae
KW - dengue 2 virus
KW - dengue virus
KW - mice
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - cDNA
KW - DNA sequences
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19970501481&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A conserved internal hydrophobic domain mediates the stable membrane integration of the dengue virus capsid protein.
AU - Markoff, L.
AU - Falgout, B.
AU - Chang, A.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1997///
VL - 233
IS - 1
SP - 105
EP - 117
SN - 0042-6822
AD - Markoff, L.: Laboratory of Vector-borne Virus Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19980501702. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The genome of dengue-4 (DEN4) virus, strain 814669, has previously been cloned and sequenced. Sequences encoding virion C (DEN4 nucleotides 102-398) were enhanced through a polymerase chain reaction which used recombinant DNA containing the bacterial plasmid vector. Mutations were created in the C region covering amino acids 45-65. Integration of C was dependent upon the integrity of the hydrophobic section specifically, and deletion or substitution mutations which destroyed the integrity of the sequence, and therefore prevented membrane integration of C. A hairpin orientation of DEN4 C was observed in the membrane, and factors influencing the orientation are further discussed.
KW - arboviruses
KW - coat proteins
KW - membranes
KW - molecular genetics
KW - viral proteins
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - biochemical genetics
KW - capsid proteins
KW - virions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980501702&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maintenance of an unusual polypurine tract in HIV-2: stability to passage in culture.
AU - Lauermann, V.
AU - Hughes, S. H.
AU - Peden, K. W. C.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1997///
VL - 236
IS - 1
SP - 208
EP - 212
SN - 0042-6822
AD - Lauermann, V.: Laboratory of Retrovirus Research, Room 3D08, Bldg 29A, Center for Biologics, Evaluation and Research, 29 Lincoln Drive, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19972009850. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2.
N2 - A stretch of purine residues, the polypurine tract (PPT), is found in all retroviruses and is used to initiate plus-strand DNA synthesis. While the PPT of most lentiviruses is a homogeneous sequence of purine residues, the PPT of some isolates of HIV and SIV is interrupted with a single pyrimidine residue. The ROD strain of HIV-2 has such a pyrimidine-containing variant PPT. Virus generated from an infectious molecular clone, pROD10, was used to infect 2 CD4+ T-cell lines, H9 and CEM. The sequence of the PPT was determined after 2 passages. From both cell lines, the variant PPT was retained, demonstrating that the presence of a pyrimidine in the PPT was fully functional and that there was no strong selection for an all-purine PPT.
KW - cell culture
KW - DNA
KW - genomes
KW - HIV-2 infections
KW - human diseases
KW - human immunodeficiency viruses
KW - microbiology
KW - nucleotides
KW - purines
KW - synthesis
KW - T lymphocytes
KW - Human immunodeficiency virus 2
KW - Lentivirus
KW - Retroviridae
KW - simian immunodeficiency virus
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - deoxyribonucleic acid
KW - genomic structure
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 2
KW - purine bases
KW - T cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009850&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - End-stage renal disease among silica-exposed gold miners. A new method for assessing incidence among epidemiologic cohorts.
AU - Calvert, G. M.
AU - Steenland, K.
AU - Palu, S.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1997///
VL - 277
IS - 15
SP - 1219
EP - 1223
SN - 0098-7484
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19972010432. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - The association between silica exposure and end-stage renal disease (ESRD) was examined in a retrospective cohort study of 2412 male gold miners who worked underground for at least 1 year during 1940-65 in a gold mine in South Dakota, USA, and were alive on January 1, 1977. The ESRD Program Management and Medical Information System (PMMIS) was used to identify members of the gold mine cohort who had treated ESRD and to create a US rate file for treated ESRD. The ESRD incidence among the gold miners was compared with that in the US population. Based on the 11 cohort members identified with treated ESRD, the risk for ESRD in the cohort was increased (standardized incidence ratio (SIR), 1.37; 95% confidence interval (CI), 0.68-2.46). The risk was greatest for non-systemic ESRD (ESRD caused by glomerulonephritis or interstitial nephritis) for which the SIR was 4.22 (95% CI, 1.54-9.19), increasing to 7.70 (95% CI, 1.59-22.48) among workers with 10 or more years of employment underground. This study provided evidence that silica exposure is associated with an increased risk for ESRD, especially ESRD caused by glomerulonephritis. The study also demonstrated the usefulness of the ESRD PMMIS to assess ESRD risk among cohorts exposed to potential nephrotoxins.
KW - epidemiology
KW - exposure
KW - glomerulonephritis
KW - gold miners
KW - human diseases
KW - kidney diseases
KW - kidneys
KW - miners
KW - nephritis
KW - occupational health
KW - silica
KW - toxicology
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010432&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Thalidomide for aphthous ulcers in HIV infection.
AU - Birnkrant, D.
AU - Jacobson, J. M.\Greenspan, J. S.\Spritzler, J.
T2 - New England Journal of Medicine
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1997///
VL - 337
IS - 15
SP - 1086
EP - 1087
SN - 0028-4793
AD - Birnkrant, D.: Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 19972009883. Publication Type: Correspondence. Language: English. Number of References: 4 ref. Registry Number: 50-35-1.
N2 - Dr Birnkrant suggests that the study by Jacobson et al., (New England Journal of Medicine (1997) 336 1487) study is too preliminary to use as a recommendation for the use of thalidomide in the treatment of aphthous ulcers in AIDS patients. Dr Jacobson et al. respond that the clinical trial was terminated early because it showed pronounced effectiveness over placebo (P=0.00001) and that even for those who left the trial earlier because of side effects of the drug, there was pronounced reduction in their lesions.
KW - acquired immune deficiency syndrome
KW - adverse effects
KW - clinical aspects
KW - clinical trials
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunomodulators
KW - lesions
KW - mouth diseases
KW - placebos
KW - thalidomide
KW - treatment
KW - ulcers
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - AIDS
KW - chemotherapy
KW - clinical picture
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972009883&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
AU - Huber, W. W.
AU - McDaniel, L. P.
AU - Kaderlik, K. R.
AU - Teitel, C. H.
AU - Lang, N. P.
AU - Kadlubar, F. F.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 1997///
VL - 376
IS - 1/2
SP - 115
EP - 122
SN - 0027-5107
AD - Huber, W. W.: Division of Molecular Epidemiology (HFT-100), National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981406024. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
KW - carcinogenesis
KW - carcinogens
KW - colon
KW - cooking
KW - damage
KW - DNA
KW - food
KW - mutagens
KW - protection
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406024&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory aspects of the introduction of new macronutrient substitutes.
AU - Rulis, A. M.
AU - Pellicore, L. S.
AU - Thorsheim, H. R.
A2 - Anderson, G. H.
A2 - Rolls, B. J.
A2 - Steffen, D. G.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1997///
VL - 819
SP - 22
EP - 28
SN - 0077-8923
AD - Rulis, A. M.: Office of Premarket Approval, HFS-200, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 19971407936. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Human Nutrition
N2 - The approvals process at the US FDA for the introduction of new macronutrient substitutes is outlined. If a substance is not generally recognized as safe, it must undergo review and approval as a food additive by the FDA prior to its use in food. The regulation of food additives is discussed and the ways in which the regulatory safety review of macro-ingredients differs from that of typical food additives are outlined. A typical petition for an additive includes a chemical profile, including identification, composition, proposed uses, intended effect, a method for quantification and, sometimes, toxicological information.
KW - carbohydrates
KW - food additives
KW - food legislation
KW - food safety
KW - lipid substitutes
KW - regulations
KW - substitutes
KW - sugar substitutes
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional implications of macronutrient substitutes
KW - rules
KW - saccharides
KW - United States of America
KW - Food Additives (QQ130)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407936&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Replacement of dietary fat with fat-free margarine alters vitamin E storage in rats.
AU - Mitchell, G. V.
AU - Grundel, E.
AU - Jenkins, M. Y.
A2 - Anderson, G. H.
A2 - Rolls, B. J.
A2 - Steffen, D. G.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1997///
VL - 819
SP - 236
EP - 238
SN - 0077-8923
AD - Mitchell, G. V.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19971407974. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 3 ref. Registry Number: 59-02-9, 8001-22-7, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Male and female Sprague-Dawley rats (n=10 per group) were fed for 6 weeks on standard diets containing blends of soyabean oil-without vitamin E and 1.75 or 4.38% vegetable oil spread (VOS) containing 6% fat and α-tocopherol 33 mg/kg or diets with the VOS portion replaced by comparable amounts (by weight) of fat-free margarine (1.75 and 4.38%) containing 3 and 4.8% fat. Male rats fed diets containing fat-free margarine consumed more (P<0.05) food by weight than the corresponding VOS groups to compensate for the reduced energy content of the diet. Differences between food intake in females fed on fat-free margarine and VOS females were not significant. Substitution of fat-free margarine did not significantly affect growth and tissue weights. Rats consuming the diets containing fat-free margarine had lower α-tocopherol intakes (P<0.05 for males and females) than those consuming the VOS diets. Levels of α-tocopherol in the liver, plasma and heart of male rats fed on the fat-free margarine were lower (P<0.05) in male VOS rats. The plasma, liver and heart α-tocopherol concentrations of female rats were not significantly affected by dietary treatment.
KW - alpha-tocopherol
KW - blood
KW - fats
KW - food intake
KW - growth
KW - heart
KW - intake
KW - lipid substitutes
KW - liver
KW - margarine
KW - plant oils
KW - sex differences
KW - soyabean oil
KW - tissues
KW - vitamin E
KW - vitamins
KW - weight
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutritional implications of macronutrient substitutes
KW - soybean oil
KW - vegetable oils
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407974&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oil-soluble vitamin content of new reduced-fat and fat-free margarines: potential implications for vitamin E intake.
AU - Rader, J. I.
A2 - Anderson, G. H.
A2 - Rolls, B. J.
A2 - Steffen, D. G.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 1997///
VL - 819
SP - 242
EP - 246
SN - 0077-8923
AD - Rader, J. I.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19971407976. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 4 ref. Registry Number: 59-02-9, 7235-40-7, 68-26-8, 8001-22-7, 8001-21-6, 1406-18-4. Subject Subsets: Human Nutrition; Soyabeans
N2 - The fat, vitamin E and vitamin A contents of 19 reduced-fat and fat-free margarine-like products available in the USA were analysed. Fat was determined gravimetrically by AOAC method 922.06. Vitamins were analysed by HPLC. In margarines containing ≥50% or more fat, individual liquid oils or blends of several liquid oils and partially hydrogenated vegetable oils were the first listed ingredient(s). Water was the predominant ingredient and a vegetable oil or a blend of vegetable oils was the second-listed ingredient for products of 20-40% fat content. The majority of the products contained <4% of the US daily value (DV) per serving of vitamin E. α-Tocopherol levels in vegetable oils decreased in the following order: sunflower, canola, maize, soyabean. All margarine products contained vitamin A (added as palmitate) in concentrations of 6-10% of the DV per serving. Values for total vitamin A (retinol plus retinol equivalents from β-carotene) were 59-195% of labelled values. All products contained β-carotene as a colorant.
KW - alpha-tocopherol
KW - beta-carotene
KW - composition
KW - fats
KW - low fat products
KW - maize oil
KW - margarine
KW - plant oils
KW - rapeseed oil
KW - retinol
KW - soyabean oil
KW - sunflower oil
KW - vitamin E
KW - vitamins
KW - water content
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - corn oil
KW - Nutritional implications of macronutrient substitutes
KW - soybean oil
KW - United States of America
KW - vegetable oils
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971407976&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV-1 infection in a man homozygous for CCR5Δ32.
AU - O'Brien, T.
AU - Winkler, C.
AU - Dean, M.
AU - Nelson, J. A. E.
AU - Carrington, M.
AU - Michael, N. L.
AU - White, G. C.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1997///
IS - 9060
SP - 1219
EP - 1219
SN - 0140-6736
AD - O'Brien, T.: Viral Epidemiology Branch and Laboratory of Genomic Diversity, National Cancer Institute, Public Health Service, US Department of Health and Human Services, Bethesda, MD 20852, USA.
N1 - Accession Number: 19972010434. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 113189-02-9, 30516-87-1.
N2 - A patient is described who was homozygous for CCR5Δ32, but nonetheless became infected with HIV-1. A white man, born in 1969 with severe haemophilia A, received over 500 000 units of Factor VIII concentrate from 1978 through 1984. He was positive for antibodies to HIV-1 at initial testing in 1985. He also had chronic hepatitis B virus antigenaemia and hepatitis C viraemia. His CD4 lymphocyte count was low (522/µl) in 1983 and fell to 158/µl by 1986. His count continued to fall (despite treatment with zidovudine beginning in 1989), but he had no HIV-1-associated conditions until oral hairy leukoplakia was diagnosed in 1983. He developed AIDS (oesophageal candidiasis) in 1985 and died of liver failure in 1996.
KW - acquired immune deficiency syndrome
KW - antibodies
KW - antigenaemia
KW - CD4 antigens
KW - chronic course
KW - concentrates
KW - factor VIII
KW - haemophilia
KW - hepatitis
KW - hepatitis B
KW - hepatitis C
KW - infection
KW - liver
KW - lymphocytes
KW - oral hairy leukoplakia
KW - treatment
KW - zidovudine
KW - hepatitis B virus
KW - Human immunodeficiency virus 1
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - AIDS
KW - antigenemia
KW - AZT
KW - CD4
KW - hemophilia
KW - human immunodeficiency virus type 1
KW - protein feeds
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19972010434&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Guidelines for school and community programs to promote lifelong physical activity among young people.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1997///
IS - RR-6
SP - 36
EP - 36
SN - 0149-2195
AD - US Department of Health and Human Services, Public Health Service Centers for Disease Control and Prevention (CDC) Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19971805687. Publication Type: Miscellaneous. Corporate Author: USA, Department of Health and Human Services, Epidemiology Program Office Language: English. Number of References: 276 ref. Subject Subsets: Leisure, Recreation, Tourism
N2 - This report summarizes recommendations for encouraging physical activity among young people so that they will continue to engage in physical activity in adulthood and obtain the benefits of physical activity throughout life. They are based on an in-depth review of research, theory, and current practice in physical education, exercise science, health education, and public health. The guidelines include recommendations about 10 aspects of school and community programmes to promote lifelong physical activity among young people: policies that promote enjoyable, life long physical activity; physical and social environments that encourage and enable physical activity; physical education curricula and instruction; health education curricula and instruction; extracurricular physical activity programmes that meet the needs and interests of students; involvement of parents and guardians in physical activity instruction and programmes for young people; personnel training; health services for children and adolescents; developmentally appropriate community sports and recreation programmes that are attractive to young people; and regular evaluation of physical activity instruction, programmes and facilities.
KW - adolescents
KW - children
KW - health promotion
KW - physical activity
KW - physical education
KW - physical fitness
KW - wellness
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - keep fit
KW - teenagers
KW - United States of America
KW - Recreation and Sport (UU620) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19971805687&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Control of veterinary drug residues in the United States of America.
AU - Thompson, S.
T2 - Proceedings of the 8th International Technical Consultation on Veterinary Drug Registration, Prague, Czech Republic, 10-13 September 1996.
JO - Proceedings of the 8th International Technical Consultation on Veterinary Drug Registration, Prague, Czech Republic, 10-13 September 1996.
JF - Proceedings of the 8th International Technical Consultation on Veterinary Drug Registration, Prague, Czech Republic, 10-13 September 1996.
Y1 - 1997///
SP - 89
EP - 92
CY - Paris; France
PB - Office International des Epizooties
AD - Thompson, S.: Center for Veterinary Medicine, USA Food and Drug Administration, 5600 Fishers Lane, Rockville MD 20857, USA.
N1 - Accession Number: 19982205400. Publication Type: Conference paper. Language: English. Subject Subsets: Veterinary Science; Animal Nutrition
KW - drug residues
KW - drugs
KW - feeds
KW - food hygiene
KW - food safety
KW - legislation
KW - pharmacology
KW - veterinary products
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - feeding stuffs
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982205400&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Molecular biology of dengue viruses.
AU - Chang, G. J.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Chang, G. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502028. Publication Type: Book chapter. Language: English. Number of References: 112 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - molecular biology
KW - molecular genetics
KW - reviews
KW - RNA
KW - viral proteins
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - biochemical genetics
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502028&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem.
AU - Gubler, D. J.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Gubler, D. J.: US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502020. Publication Type: Book chapter. Language: English. Number of References: 83 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - dengue
KW - dengue haemorrhagic fever
KW - emerging infectious diseases
KW - history
KW - human diseases
KW - reviews
KW - Africa
KW - America
KW - Asia
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - man
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - arthropod-borne viruses
KW - dengue hemorrhagic fever
KW - emerging diseases
KW - emerging infections
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - History and Biography (BB500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502020&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Dengue and dengue hemorrhagic fever.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502019. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - This book provides a detailed and up-to-date discussion of all major topics related to dengue viruses, written in a style that can be used by graduate students, research scientists, public health officials and physicians. The 20 chapters are written by 28 experts from around the world, who, while reviewing earlier work, emphasize recent scientific advances. The book is divided into 4 parts: natural history: history, epidemiology, virus-vector relationships and transmission dynamics (4 chapters); clinical aspects and treatment, including clinical diagnosis and pathology (3 chapters); the viruses and immune responses: systematics, antigenic relationships, molecular biology, immunology, pathogenesis and laboratory diagnosis (9 chapters); and prevention and control, addressing vaccines, surveillance and mosquito control (4 chapters). The book should stimulate new research that will answer unresolved issues surrounding dengue haemorrhagic fever, and ultimately lead to effective strategies for prevention of this important global public health problem.
KW - arboviruses
KW - dengue
KW - dengue haemorrhagic fever
KW - diagnosis
KW - disease control
KW - disease vectors
KW - epidemiology
KW - human diseases
KW - immunopathology
KW - molecular genetics
KW - pathogenesis
KW - therapy
KW - vaccines
KW - vector control
KW - Aedes aegypti
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - arthropod-borne viruses
KW - biochemical genetics
KW - dengue hemorrhagic fever
KW - immunopathogenesis
KW - mosquitoes
KW - therapeutics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502019&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Factors influencing the transmission of dengue viruses.
AU - Kuno, G.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Kuno, G.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 19980502023. Publication Type: Book chapter. Language: English. Number of References: 152 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - dengue
KW - disease transmission
KW - disease vectors
KW - environmental factors
KW - epidemiology
KW - human diseases
KW - reviews
KW - Aedes
KW - Aedes aegypti
KW - Aedes albopictus
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - man
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502023&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Surveillance and control of urban dengue vectors.
AU - Reiter, P.
AU - Gubler, D. J.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Reiter, P.: Dengue Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 2 Calle Casia, San Juan, PR 00921-3200, Puerto Rico.
N1 - Accession Number: 19980502039. Publication Type: Book chapter. Language: English. Number of References: 135 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - chemical control
KW - dengue
KW - disease vectors
KW - environmental management
KW - reviews
KW - surveillance
KW - ultralow volume spraying
KW - urban areas
KW - vector control
KW - water containers
KW - Cuba
KW - Singapore
KW - Aedes aegypti
KW - Aedes albopictus
KW - Culicidae
KW - dengue virus
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - APEC countries
KW - ASEAN Countries
KW - Commonwealth of Nations
KW - South East Asia
KW - Asia
KW - Threshold Countries
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Environmental Pest Management (HH200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502039&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Surveillance for dengue and dengue hemorrhagic fever.
AU - Rigau-Pérez, J. G.
AU - Gubler, D. J.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Rigau-Pérez, J. G.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 2 Calle Casia, San Juan, PR 00921-3200, Puerto Rico.
N1 - Accession Number: 19980502038. Publication Type: Book chapter. Language: English. Number of References: 68 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - control programmes
KW - dengue
KW - disease control
KW - disease surveys
KW - epidemiology
KW - human diseases
KW - reviews
KW - serological surveys
KW - surveillance
KW - dengue virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arthropod-borne viruses
KW - control programs
KW - disease surveillance
KW - seroepidemiology
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502038&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Immunochemistry of dengue viruses.
AU - Roehrig, J. T.
A2 - Gubler, D. J.
A2 - Kuno, G.
T2 - Dengue and dengue hemorrhagic fever.
Y1 - 1997///
CY - Wallingford; UK
PB - CAB INTERNATIONAL
SN - 0851991343
AD - Roehrig, J. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980502029. Publication Type: Book chapter. Language: English. Number of References: 87 ref. Subject Subsets: Medical & Veterinary Entomology
KW - antigens
KW - arboviruses
KW - epitopes
KW - immunochemistry
KW - reviews
KW - viral proteins
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenic determinants
KW - antigenicity
KW - arthropod-borne viruses
KW - immunogens
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980502029&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food microbiological analysis: new technologies.
A2 - Tortorello, M. L.
A2 - Gendel, S. M.
T2 - Food microbiological analysis: new technologies.
Y1 - 1997///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824700872
AD - National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Illinois, USA.
N1 - Accession Number: 19981410375. Publication Type: Conference proceedings; Book. Language: English. Subject Subsets: Human Nutrition
N2 - This book contains the proceedings of the 1996 Basic Symposium of the Institute of Food Technologists. It is divided into 3 parts. Part I, detection and identification systems contains the chapters: overview of rapid methods of microbiological analysis; separation and concentration of pathogens from foods; a new look at an old technique: application of microscopy to food microbiological analysis; flow cytometry in food microbiology: detection of Escherichia coli O157:H7; optical biosensors for microbiological analysis; immuno-diagnostic in the detection of foodborne pathogens; and automated microbial identification systems. Part II, genetic techniques on analysis contains the chapters: applications of gene probes for the detection of foodborne pathogens; PCR and nucleic acid amplification methods; detection of microorganisms in foods using DNA probes targeted top ribosomal RNA sequences; gene sequence databases and food microbiology; molecular fingerprinting of foodborne pathogenic bacteria: and an introduction to methods, uses and probes. Part III, methods for assessment of microbial growth and viability contains the chapters: bioluminescence: lux as an enabling tool for the microbiological analysis of food; detection of visible but non-culturable and stressed microbial cells; measurement of microbial activity by impedance; and special techniques for studying microbial biofilms in food systems.
KW - analytical methods
KW - biosensors
KW - DNA probes
KW - flow cytometry
KW - food contamination
KW - food microbiology
KW - foods
KW - impedance
KW - luminescence
KW - microbial contamination
KW - microorganisms
KW - microscopy
KW - pathogens
KW - polymerase chain reaction
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - food contaminants
KW - gene probes
KW - micro-organisms
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981410375&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - New techniques and applications in lipid analysis.
A2 - McDonald, R. E.
A2 - Mossoba, M. M.
T2 - New techniques and applications in lipid analysis.
Y1 - 1997///
CY - Champaign; USA
PB - AOCS Press
SN - 0935315802
AD - Correspondence address: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Illinois, USA.
N1 - Accession Number: 19981404162. Publication Type: Book. Language: English. Number of References: many ref. Registry Number: 25167-62-8, 60-33-3. Subject Subsets: Human Nutrition
N2 - This multiauthor book on lipid analysis consists of 18 chapters: (1) newer methods for fat analysis in foods; (2) use of stable isotopes to study incorporation of dietary fat into blood lipids; (3) qualitative and quantitative analysis of triacylglycerols using atmospheric-pressure chemical ionization mass spectrometry; (4) liquid chromatography with on-line electrospray mass spectrometry of oxidized diphosphatidylglycerol; (5) stereospecific analysis of docosahexaenoic acid-rich triacylglycerols by chiral-phase HPLC with online electrospray mass spectrometry; (6) NMR characterization of fatty compounds obtained via selenium dioxide-based oxidations; (7) supercritical-fluid chromatography: a shortcut in lipid analysis; (8) analysis of unusual triglycerides and lipids using supercritical-fluid chromatography; (9) oxidation products of conjugated linoleic acid and furan fatty acids; (10) analysis of lipid oxidation products by combination of chromatographic techniques; (11) analysis of trans fatty acids; (12) separation of fatty acid methyl esters and triacylglycerols by Ag-HPLC: silver-ion and normal-phase contribution to retention; (13) near infrared analysis of oilseeds: current status and future directions; (14) application of Fourier transform infrared spectroscopy in edible oil analysis; (15) recent applications of Iatroscan TLC-FID methodology; (16) natural antioxidants in lipids; (17) coffee lipids: analysis of the diterpene 16-O-methylcafestol as an indicator of admixing of coffees; (18) improvements in recovery of petroleum hydrocarbons from marine fish, crabs and mussels.
KW - analytical methods
KW - antioxidants
KW - blood lipids
KW - coffee
KW - diphosphatidylglycerols
KW - diterpenes
KW - docosahexaenoic acid
KW - fats
KW - fatty acid esters
KW - fatty acids
KW - fish
KW - HPLC
KW - infrared spectroscopy
KW - isotopes
KW - linoleic acid
KW - lipids
KW - liquid chromatography
KW - mass spectrometry
KW - mussels
KW - nuclear magnetic resonance
KW - oils
KW - oilseeds
KW - petroleum hydrocarbons
KW - thin layer chromatography
KW - trans fatty acids
KW - triacylglycerols
KW - Coffea
KW - crabs
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - analytical techniques
KW - high performance liquid chromatography
KW - lipins
KW - phosphatidylglycerols
KW - supercritical fluid chromatography
KW - triglycerides
KW - Food Composition and Quality (QQ500)
KW - Physiology of Human Nutrition (VV120)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology and prevention of helicopter logging injuries.
AU - Conway, G. A.
AU - Manwaring, J. C.
A2 - Langley, R. L.
A2 - McLymore, R. L.
A2 - Meggs, W. J.
A2 - Roberson, G. T.
T2 - Safety and health in agriculture, forestry, and fisheries.
Y1 - 1997///
CY - Rockville; USA
PB - Government Institutes, Inc.
SN - 0865875529
AD - Conway, G. A.: U. S. Public Health Service, Centers For Disease Control and Prevention (CDC), National Institute For Occupational Safety and Health (NIOSH), Division of Safety Research Alaska Field Station.
N1 - Accession Number: 19980613509. Publication Type: Book chapter. Language: English. Number of References: 30 ref.
N2 - Helicopters have been successfully utilized in transporting timber while helping prevent erosion secondary to decreased road construction in logging areas. Unfortunately, however, numerous helicopter crashes and fatalities have occurred, and several of these are described. An overview is provided on the hazards of helicopters and sling-load logging operations. Recent experience with the use of helicopters in logging operations in Alaska is presented. Information is also presented on the larger US experience with this rapidly expanding industry, and recommendations are made for the prevention of injuries by addressing factors such as equipment, maintenance, human factors, training, management, oversight, interagency/company cooperation and the environment.
KW - accident prevention
KW - accidents
KW - forestry
KW - helicopters
KW - logging
KW - safety at work
KW - trauma
KW - Alaska
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - timber extraction
KW - timber harvesting
KW - traumas
KW - United States of America
KW - Logging and Wood Processing (KK515)
KW - Occupational Health and Safety (VV900)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980613509&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modification of biological activities of phytoestrogens by intestinal microflora.
AU - Rafii, F.
JO - Recent Research Developments in Agricultural & Food Chemistry
JF - Recent Research Developments in Agricultural & Food Chemistry
Y1 - 1998///
VL - 2
IS - 2
SP - 803
EP - 809
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991411993. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - A review.
KW - digestive tract
KW - health
KW - intestinal microorganisms
KW - metabolism
KW - microbial flora
KW - neoplasms
KW - plant oestrogens
KW - plant products
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - crop products
KW - gastrointestinal tract
KW - gut flora
KW - intestinal micro-organisms
KW - microflora
KW - phytoestrogens
KW - plant estrogens
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411993&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Collaboration in the fight against infectious diseases.
AU - Shalala, D. E.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 1998///
VL - 4
IS - 3
SP - 354
EP - 357
AD - Shalala, D. E.: US Department of Health and Human Services, USA.
N1 - Accession Number: 19990502297. Publication Type: Journal Article. Language: English.
KW - disease control
KW - human diseases
KW - infectious diseases
KW - surveillance
KW - collaboration
KW - communicable diseases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502297&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - NIOSH perspective on tractor-related hazards.
AU - Myers, M. L.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 1998///
VL - 4
IS - 4
SP - 205
EP - 230
AD - Myers, M. L.: NIOSH, U.S. Public Health Service, 1293 Berkeley Road, Avondale Estates, GA 30002, USA.
N1 - Accession Number: 19992401709. Publication Type: Journal Article. Language: English. Number of References: 6 pp. of ref. Subject Subsets: Agricultural Engineering
N2 - The (USA) National Institute for Occupational Safety and Health (NIOSH) initiated a research-based prevention program in agricultural safety and health in 1990, and part of that program focuses on hazards associated with tractors. The program incorporates both intramural and extramural components and includes 3 principal elements: surveillance, research, and intervention. This program has improved the characterization of tractor-related hazards, increased knowledge about using roll-over protective structures (ROPS), and disseminated information as a strategy to prevent tractor-related injuries. NIOSH has identified machine-related injuries as a priority area, which includes preventing tractor-related injuries. In addition, the Department of Health and Human Services, of which NIOSH is a part, is considering a national objective to promote the installation of a ROPS on every tractor used in agricultural production.
KW - roll over protection structures
KW - safety
KW - safety devices
KW - tractors
KW - antiroll structures
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992401709&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hazard assessment of ackee fruit (Blighia sapida).
AU - Henry, S. H.
AU - Page, S. W.
AU - Bolger, P. M.
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
Y1 - 1998///
VL - 4
IS - 5
SP - 1175
EP - 1187
AD - Henry, S. H.: Contaminants Standards and Monitoring Branch, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, D.C. HFS-308, 200 C St. S.W., Washington, D.C., 20204, USA.
N1 - Accession Number: 19991405130. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 50-99-7, 156-56-9. Subject Subsets: Human Nutrition
N2 - Ackee toxicity is associated with consumption of the fruit of the tree B. sapida. The problem is endemic in Jamaica, and a number of cases have been reported in the US among Jamaican immigrants. Illness is associated with the method of preparation of the fruit and its ripeness. Malnourished individuals and children appear to be the most susceptible. Levels of the toxic compound, hypoglycine, which are found in the arils and seeds of the fruit, significantly decrease in the arils with ripeness (from 1000 to <0.1 mg/kg). Symptoms of ackee poisoning in man occur 6-48 h after ingestion and include vomiting, muscular and mental exhaustion, hypoglycaemia, coma and death. Intravenous glucose relieves the hypoglycaemia. The most likely mechanism of action occurs through the incorporation of hypoglycine into fatty acid metabolic pathways. Hypoglycine or its primary metabolite methylenecyclopropyl-acetyl-CoA inhibits the oxidation of fatty acids and leucine and the activity of acyl-CoA dehydrogenases. The dose required to elicit acute responses is not known with any precision, nor is it possible to eliminate the likelihood of adverse effects with long-term ingestion of the toxin. It is concluded that the ingestion of unripe aril or pod and seeds represents a significant health hazard, this hazard diminishes considerably with the consumption of properly processed or prepared ripe fruit.
KW - coma
KW - exhaustion
KW - fruit
KW - glucose
KW - hypoglycaemia
KW - hypoglycine A
KW - mortality
KW - poisoning
KW - seeds
KW - subtropical tree fruits
KW - toxicity
KW - vomiting
KW - Jamaica
KW - USA
KW - Blighia sapida
KW - Blighia
KW - Sapindaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - ACP Countries
KW - Caribbean Community
KW - Commonwealth of Nations
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Threshold Countries
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - death rate
KW - dextrose
KW - hypoglycemia
KW - low blood glucose
KW - toxicosis
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991405130&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cell wall preparations from environmental yeasts: effect on alveolar macrophage function in vitro.
AU - Sorenson, W. G.
AU - Shahan, T. A.
AU - Simpson, J.
JO - Annals of Agricultural and Environmental Medicine
JF - Annals of Agricultural and Environmental Medicine
Y1 - 1998///
VL - 5
IS - 1
SP - 65
EP - 71
AD - Sorenson, W. G.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19991201380. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Preparations from the cell walls of Pichia fabianii [Hansenula fabianii], Candida sake, Trichosporon capitatum [Blastoschizomyces capitatus], Rhodotorula glutinis and Cryptococcus laurentii were compared with zymosan and β-1,3-glucan for their ability to stimulate alveolar macrophages (AM) and activate complement. All species activated complement. H. fabianii, C. sake, B. capitatus, R. glutinis, C. laurentii, as well as zymosan and glucan, stimulated superoxide anion and leukotriene B4 production in a dose-dependent fashion, but R. glutinis and C. laurentii were much less active. Zymosan, glucan, H. fabianii and R. glutinis treatment of AM resulted in increased phagocytosis of labelled sheep RBCs, whereas there was no effect with C. sake or C. laurentii and B. capitatus significantly inhibiting phagocytosis. It is suggested that exposure to high concentrations of yeast could provoke pulmonary inflammation resulting in an episode of organic dust toxic syndrome.
KW - allergies
KW - cell walls
KW - human diseases
KW - lungs
KW - macrophages
KW - phagocytosis
KW - yeasts
KW - Candida
KW - Cryptococcus laurentii
KW - Hansenula
KW - man
KW - Rhodotorula glutinis
KW - Saccharomycetaceae
KW - Trichosporon capitatum
KW - fungi
KW - eukaryotes
KW - Blastoschizomyces
KW - Dipodascaceae
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - Cryptococcus (Fungi)
KW - Tremellaceae
KW - Tremellales
KW - Tremellomycetes
KW - Agaricomycotina
KW - Basidiomycota
KW - Pichiaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Rhodotorula
KW - Sporidiobolales
KW - Microbotryomycetes
KW - Pucciniomycotina
KW - Candida
KW - Hansenula
KW - Trichosporon
KW - Trichosporonaceae
KW - Blastoschizomyces capitatus
KW - Candida sake
KW - fungus
KW - Hansenula fabianii
KW - Hyphomycetes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute rheumatic fever and rheumatic heart disease: a prevention program for the Pacific.
AU - Auerbach, S. B.
JO - Pacific Health Dialog
JF - Pacific Health Dialog
Y1 - 1998///
VL - 5
IS - 1
SP - 176
EP - 179
SN - 1015-7867
AD - Auerbach, S. B.: Department of Health & Human Services, Health Resources and Services Administration, Room 3337, RCSB, 26 Federal Plaza, New York, NY 10278, USA.
N1 - Accession Number: 19982011943. Publication Type: Journal Article. Language: English. Number of References: 10 ref.
N2 - The extent of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) in Micronesia is assessed and a 6 part prevention programme is proposed as follows: give an intramuscular benzathine penicillin injection to everyone who has had one or more episodes of ARF or RHD every 21-28 days to prevent recurrent episodes; screen all children aged 5-18 years for heart murmurs; educate parents and children to recognise and seek care for all sore throats, arthralgia or arthritis; treat all children with clinical pharyngitis with a single dose of intramuscular benzathine penicillin; treat all contacts of ARF cases presumptively with a single dose of intramuscular benzathine penicillin; and carry out presumptive treatment in high prevalence areas and groups with a single dose of intramuscular benzathine penicillin.
KW - bacterial diseases
KW - children
KW - disease control
KW - disease prevention
KW - drug therapy
KW - epidemiology
KW - group A streptococci
KW - health education
KW - heart diseases
KW - human diseases
KW - penicillins
KW - pharyngitis
KW - prophylaxis
KW - rheumatic fever
KW - screening
KW - Micronesia
KW - man
KW - Streptococcus pyogenes
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Oceania
KW - Pacific Islands
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - coronary diseases
KW - screening tests
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011943&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Capture of an early fusion-active conformation of HIV-1 gp41.
AU - Furuta, R. A.
AU - Wild, C. T.
AU - Weng YongKai
AU - Weiss, C. D.
JO - Nature Structural Biology
JF - Nature Structural Biology
Y1 - 1998///
VL - 5
IS - 4
SP - 276
EP - 279
SN - 1072-8368
AD - Furuta, R. A.: Office of Vaccines, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm 532, HFM-413, 29 Lincoln Dr., Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 19982006861. Publication Type: Journal Article. Language: English. Number of References: 28 ref.
N2 - By means of an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry was trapped. The data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.
KW - cell fusion
KW - conformation
KW - envelope glycoproteins
KW - envelope protein gp120
KW - envelope protein gp41
KW - glycoproteins
KW - human diseases
KW - inhibition
KW - synthetic peptides
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - body conformation
KW - gp120
KW - gp41
KW - human immunodeficiency virus type 1
KW - Human Physiology and Biochemistry (VV050)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006861&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L.) Michx.
AU - Betz, J. M.
AU - Andrzejewski, D.
AU - Troy, A.
AU - Casey, R. E.
AU - Obermeyer, W. R.
AU - Page, S. W.
AU - Woldemariam, T. Z.
JO - Phytochemical Analysis
JF - Phytochemical Analysis
Y1 - 1998///
VL - 9
IS - 5
SP - 232
EP - 236
SN - 0958-0344
AD - Betz, J. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19990300026. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - C. thalictroides is a North American perennial herb which is used as an ingredient in dietary supplement products in the United States. The plant contains the alkaloids N-methylcytisine, baptifoline, anagyrine and magnoflorine. Some of the alkaloids, including the quinolizidine alkaloid anagyrine, are toxic to range animals and have been implicated as teratogens in higher animals. Since the traditional use of the herb involves administration to women of reproductive age to treat menstrual cramps, and to pregnant women in the last 3-4 weeks of pregnancy to ease parturition, the safety of these products to the fetus is of concern. Three of these alkaloids were detected in the plant and in several dietary supplements (5-850 ppm for N-methylcytisine; 2-390 ppm for anagyrine; and 9-900 ppm for baptifoline). Lower alkaloid concentrations were found in products containing liquid extracts.
KW - alkaloids
KW - analytical methods
KW - determination
KW - gas chromatography
KW - herbal drugs
KW - isoquinoline alkaloids
KW - plant composition
KW - plant extracts
KW - pregnancy
KW - quinolizidine alkaloids
KW - safety
KW - spectrometry
KW - supplements
KW - toxic substances
KW - toxicology
KW - women
KW - USA
KW - Berberidaceae
KW - man
KW - Ranunculales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Berberidaceae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - Caulophyllum
KW - Caulophyllum thalictroides
KW - chemical constituents of plants
KW - gestation
KW - herbal medicines
KW - poisons
KW - United States of America
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of a coded panel of licensed vaccines by polymerase chain reaction-based reverse transcriptase assays: a collaborative study.
AU - Maudru, T.
AU - Peden, K. W. C.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 1998///
VL - 11
IS - 1
SP - 19
EP - 28
AD - Maudru, T.: Laboratory of Retrovirus Research, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 19992001859. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9068-38-6.
N2 - Coded panels of licensed vaccines together with positive and negative controls were assembled at the Center for Biologics Evaluation and Research (CBER) of the Food and Drug Administration (FDA), Bethesda, MD, USA, and distributed to 5 cooperating laboratories as well as to the laboratory at CBER. Each laboratory carried out their version of the polymerase chain reaction-based reverse transcriptase (PBRT) assay and submitted the results to the coordinator at CBER. Results of the PBRT analyses carried out in the 6 laboratories are presented. Five of the 6 laboratories reported results that were highly consistent. RT activity was detected in live attenuated vaccines that were prepared in chick embryo cells (mumps, measles and yellow fever), but very low or undetectable reverse transcriptase (RT) activity was found in vaccines produced in mammalian cells (rabies and rubella). Influenza vaccines from several manufacturers included in the panel displayed the most variability, with different products of this inactivated vaccine having differing amounts of RT activity. Only vaccines produced in chick embryo cells had significant RT activity. Because RT activity was present in the allantoic fluid of uninfected chick embryos and culture medium from chick embryo fibroblasts, the RT activity arises from the cell substrate used for vaccine production. The PBRT assays were reliably able to detect the low levels of RT activity in chicken-derived vaccines.
KW - human diseases
KW - reverse transcriptase
KW - safety
KW - vaccines
KW - USA
KW - man
KW - Retroviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001859&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dengue and dengue hemorrhagic fever.
AU - Gubler, D. J.
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
Y1 - 1998///
VL - 11
IS - 3
SP - 480
EP - 496
SN - 0893-8512
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990503294. Publication Type: Journal Article. Language: English. Number of References: 156 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - dengue
KW - dengue haemorrhagic fever
KW - reviews
KW - Aedes
KW - Culicidae
KW - dengue virus
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - dengue hemorrhagic fever
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503294&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessing the potential allergenicity of new food proteins.
AU - Gendel, S. M.
JO - Food Biotechnology
JF - Food Biotechnology
Y1 - 1998///
VL - 12
IS - 3
SP - 175
EP - 185
SN - 0890-5436
AD - Gendel, S. M.: Biotechnology Studies Branch, Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Rd. Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 19991400333. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - The difficulty in assessing the overall safety of transgenic foods in terms of the potential allergenicity of transferred proteins is reviewed. Allergenicity is discussed in terms of the source of the transferred protein, expression levels in food, physical and chemical properties of the protein and similarity to known allergens.
KW - allergens
KW - biotechnology
KW - food allergies
KW - food safety
KW - foods
KW - genetic engineering
KW - genetically engineered organisms
KW - immune response
KW - proteins
KW - public health
KW - recombinant DNA
KW - reviews
KW - transgenic plants
KW - transgenics
KW - man
KW - plants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food hypersensitivity
KW - genetic manipulation
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - immunity reactions
KW - immunological reactions
KW - Food Science and Food Products (Human) (QQ000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400333&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interleukin-2 inhibits HIV-1 replication in human macrophages by modulating expression of CD4 and CC-chemokine receptor-5.
AU - Kutza, J.
AU - Hayes, M. P.
AU - Clouse, K. A.
JO - AIDS
JF - AIDS
Y1 - 1998///
VL - 12
IS - 8
SP - F59
EP - F64
SN - 0269-9370
AD - Kutza, J.: Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29B HFM-505, 8800 Rockville Pike, Bethesda, MD 20852, USA.
N1 - Accession Number: 19982008022. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 102524-44-7, 85898-30-2.
N2 - To determine the effect of recombinant human interleukin (IL)-2 on HIV-1 replication and macrophage colony stimulating factor (M-CSF) production by HIV-1 infected monocyte-derived macrophages (MDMs). Therapeutic use of IL-2 increases the number and function of CD4+ T cells. IL-2 also increases M-CSF production and M-CSF receptor expression by human monocytes, but the subsequent effects on HIV-1 replication in MDMs have yet to be determined. MDMs from HIV-1-seronegative donors were cultured in the presence and absence of IL-2 and infected with HIV-1. Harvested supernatants were monitored for reserve transcriptase activity and M-CSF production. Reverse transcription activity was significantly lower when MDM cultures were treated with IL-2 for 10 days prior to infection with HIV-1. IL-2 did not stimulate production of inhibitory chemokines or cytokines, but FACS analysis revealed that expression of CD4, the primary HIV-1 receptor, and CC-chemokine receptor-5, a coreceptor used by macrophage-tropic viruses, are down modulated after treatment with IL-2. IL-2 may not only be of benefit in restoring immune function in AIDS patients, but may also help to prevent the infection of healthy macrophages by decreasing their expression of HIV-1 receptors.
KW - acquired immune deficiency syndrome
KW - CD4+ lymphocytes
KW - colony stimulating factor
KW - cytokines
KW - human diseases
KW - immune response
KW - immunotherapy
KW - inhibition
KW - interleukin 2
KW - macrophages
KW - monocytes
KW - replication
KW - transcription
KW - treatment
KW - viral replication
KW - Human immunodeficiency virus 1
KW - man
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - CD4+ cells
KW - DNA transcription
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008022&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression.
AU - Xiao LiHua
AU - Rudolph, D. L.
AU - Owen, S. M.
AU - Spira, T. J.
AU - Lal, R. B.
JO - AIDS
JF - AIDS
Y1 - 1998///
VL - 12
IS - 13
SP - F137
EP - F143
SN - 0269-9370
AD - Xiao LiHua: HIV/Retrovirus Diseases Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Services, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19982014619. Publication Type: Journal Article. Language: English. Number of References: 24 ref.
KW - chemokines
KW - cytokines
KW - disease course
KW - human diseases
KW - pathogenesis
KW - receptors
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - disease progression
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982014619&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors in the emergence of food borne diseases.
AU - Altekruse, S. F.
AU - Swerdlow, D.
AU - Wells, S. J.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 1
EP - 15
SN - 0749-0720
AD - Altekruse, S. F.: Food and Drug Administration Liaison, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Foodborne and Diarrheal Diseases Branch, 1600 Clifton Road (A38), Atlanta, GA 30333, USA.
N1 - Accession Number: 19982207014. Publication Type: Journal Article. Language: English. Number of References: 80 ref. Subject Subsets: Veterinary Science
KW - consumer protection
KW - disease control
KW - disease prevention
KW - diseases
KW - drug resistance
KW - emergence
KW - food
KW - food contamination
KW - food hygiene
KW - food safety
KW - microbial contamination
KW - public health
KW - reviews
KW - Campylobacter jejuni
KW - Escherichia coli
KW - Listeria monocytogenes
KW - man
KW - Salmonella
KW - Vibrio
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrionaceae
KW - Vibrionales
KW - bacterium
KW - consumer advocacy
KW - E. coli
KW - food borne diseases
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207014&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Microbial food borne pathogens.
A2 - Hung, E. (Consulting Editor)
A2 - Tollefson, L.
T2 - Veterinary Clinics of North America, Food Animal Practice
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 1
EP - 176
SN - 0749-0720
AD - Office of Surveillance and Compliance, Centre for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207027. Publication Type: Miscellaneous. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - The papers in this issue include: Factors in the emergence of food borne diseases; Salmonella; Campylobacter jejuni; Escherichia coli O157:H7; Transmissible spongiform encephalopathies in food animals; Other food borne infections; Food borne disease summary by food commodity; Food borne microbial pathogens of cultured aquatic species; Listeriosis; The National Animal Health Monitoring System; National surveillance for antibiotic resistance in zoonotic enteric pathogens; Pathogen reduction and hazard analysis and critical control point (HACCP) systems for meat and poultry; and Determining the burden on human illness from food borne diseases. There is an index.
KW - animal health
KW - bacterial diseases
KW - drug resistance
KW - food
KW - food hygiene
KW - foodborne diseases
KW - meat
KW - poultry
KW - public health
KW - Campylobacter jejuni
KW - Escherichia coli
KW - Listeria
KW - man
KW - Salmonella
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal health programmes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - domesticated birds
KW - E. coli
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Health and Hygiene (General) (LL800)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207027&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Salmonella.
AU - Ekperigin, H. E.
AU - Nagaraja, K. V.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 17
EP - 29
SN - 0749-0720
AD - Ekperigin, H. E.: Feed Safety Team, Division of Animal Feeds, Center for Veterinary Medicine, Food and Drug Administration, 7500 Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207015. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Veterinary Science; Poultry; Pig Science
KW - antigens
KW - diagnosis
KW - disease control
KW - disease distribution
KW - disease prevention
KW - epidemiology
KW - food hygiene
KW - food safety
KW - foodborne diseases
KW - poultry
KW - public health
KW - reviews
KW - salmonellosis
KW - serotypes
KW - cattle
KW - fowls
KW - goats
KW - pigs
KW - Salmonella
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Capra
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Ovis
KW - antigenicity
KW - bacterium
KW - chickens
KW - domesticated birds
KW - hogs
KW - immunogens
KW - Salmonella infections
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207015&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Campylobacter jejuni.
AU - Altekruse, S. F.
AU - Swerdlow, D. L.
AU - Stern, N. J.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 31
EP - 40
SN - 0749-0720
AD - Altekruse, S. F.: Food and Drug Administration Liaison at Centers for Disease Control and Prevention, National Center for Infectious Diseases, Foodborne and Diarrheal Diseases Branch, 1600 Clifton Road (A38), Atlanta, GA 30333, USA.
N1 - Accession Number: 19982207016. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Veterinary Science; Poultry; Pig Science
KW - disease control
KW - disease prevention
KW - drug resistance
KW - epidemiology
KW - food contamination
KW - food hygiene
KW - poultry
KW - public health
KW - reviews
KW - Campylobacter
KW - Campylobacter jejuni
KW - cattle
KW - fowls
KW - pigs
KW - sheep
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Campylobacter
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - bacterium
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - hogs
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207016&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transmissible spongiform encephalopathies in food animals. Human food safety and animal feed safety concerns for veterinarians.
AU - Godon, K. A. H.
AU - Honstead, J.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 49
EP - 70
SN - 0749-0720
AD - Godon, K. A. H.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207018. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Subject Subsets: Veterinary Science
KW - bovine spongiform encephalopathy
KW - diagnosis
KW - disease control
KW - disease prevention
KW - epidemiology
KW - food
KW - food safety
KW - nervous system diseases
KW - pathogenesis
KW - prion diseases
KW - public health
KW - safety
KW - scrapie
KW - spongiform encephalopathy
KW - transmissible mink encephalopathy
KW - veterinarians
KW - zoonoses
KW - animals
KW - goats
KW - sheep
KW - eukaryotes
KW - Capra
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Ovis
KW - bovine encephalopathy
KW - BSE
KW - chronic wasting diseases
KW - mad cow disease
KW - neuropathy
KW - veterinary surgeons
KW - vets
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Non-Communicable Diseases and Injuries of Animals (LL860)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207018&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Other food borne infections.
AU - Miller, M. A.
AU - Paige, J. C.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 71
EP - 89
SN - 0749-0720
AD - Miller, M. A.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, HVF-218, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207019. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Veterinary Science
KW - antiinfective agents
KW - diagnosis
KW - disease control
KW - disease prevention
KW - epidemiology
KW - food
KW - food hygiene
KW - foodborne diseases
KW - infections
KW - public health
KW - reviews
KW - Brucella
KW - Cryptosporidium
KW - Cyclospora
KW - Mycobacterium
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Eimeriidae
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - antimicrobials
KW - bacterium
KW - Yersinia
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207019&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food borne microbial pathogens of cultured aquatic species.
AU - Greenlees, K. J.
AU - Machado, J.
AU - Bell, T.
AU - Sundlof, S. F.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 101
EP - 112
SN - 0749-0720
AD - Greenlees, K. J.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207021. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Veterinary Science
KW - clams
KW - crayfish
KW - disease control
KW - disease prevention
KW - fish
KW - food
KW - food hygiene
KW - foodborne diseases
KW - lobsters
KW - mussels
KW - oysters
KW - pathogens
KW - public health
KW - reviews
KW - shellfish
KW - shrimps
KW - species
KW - Crustacea
KW - Edwardsiella tarda
KW - enterococcus
KW - Escherichia coli
KW - Plesiomonas shigelloides
KW - Salmonella
KW - Streptococcus iniae
KW - Vibrio
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - Edwardsiella (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Escherichia
KW - Plesiomonas
KW - Vibrionaceae
KW - Vibrionales
KW - Streptococcus
KW - Streptococcaceae
KW - Aeromonas hydrophil
KW - bacterium
KW - E. coli
KW - Mycobacterium merinum
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquaculture (Animals) (MM120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207021&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Listeriosis.
AU - Cooper, J.
AU - Walker, R. D.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 113
EP - 125
SN - 0749-0720
AD - Cooper, J.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207022. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Veterinary Science; Animal Nutrition
KW - diagnosis
KW - disease control
KW - disease prevention
KW - epidemiology
KW - feeds
KW - food contamination
KW - listeriosis
KW - pregnancy
KW - public health
KW - reviews
KW - silage
KW - goats
KW - Listeria
KW - sheep
KW - Capra
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Ovis
KW - bacterium
KW - feeding stuffs
KW - food contaminants
KW - gestation
KW - listerellosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207022&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National surveillance for antibiotic resistance in zoonotic enteric pathogens.
AU - Tollefson, L.
AU - Angulo, F. J.
AU - Fedorka-Cray, P. J.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1998///
VL - 14
IS - 1
SP - 141
EP - 150
SN - 0749-0720
AD - Tollefson, L.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855, USA.
N1 - Accession Number: 19982207024. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science
KW - antibiotics
KW - drug resistance
KW - foodborne diseases
KW - pathogens
KW - public health
KW - resistance
KW - surveillance
KW - veterinary medicine
KW - veterinary products
KW - zoonoses
KW - Campylobacter
KW - Escherichia coli
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - animal health products
KW - bacterium
KW - E. coli
KW - zoonotic infections
KW - Pesticide and Drug Resistance (HH410)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982207024&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simplification of adult mosquito bioassays through use of time-mortality determinations in glass bottles.
AU - Brogdon, W. G.
AU - McAllister, J. C.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1998///
VL - 14
IS - 2
SP - 159
EP - 164
SN - 8756-971X
AD - Brogdon, W. G.: Entomology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19980506630. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 14816-20-7, 122-14-5, 91465-08-6, 121-75-5, 300-76-5, 52645-53-1, 10453-86-8. Subject Subsets: Medical & Veterinary Entomology
N2 - A simple method is described for treating 250-ml glass Wheaton bottles with insecticide, and using them as test chambers for detecting insecticide resistance in mosquito and sandfly populations. The methods for treating bottles, obtaining baseline data and applying this technique to insects from the field are described. Sample data are presented from tests run on different vector species (Anopheles albimanus, A. gambiae, A. dirus, A. stephensi, A. freeborni, Aedes aegypti, A. albopictus, Culex restuans, C. pipiens, C. nigripalpus, C. salinarius, C. territans and Lutzomyia youngi) using a variety of insecticides (including permethrin, lambda-cyhalothrin, resmethrin, naled, malathion, chlorphoxim and fenitrothion). Time-mortality data from the bottle bioassay are presented alongside results from biochemical detection methods applied to the same mosquito population. The potential role, advantages and limitations of the time-mortality bottle method are discussed.
KW - bioassays
KW - chlorphoxim
KW - detection
KW - fenitrothion
KW - insecticide resistance
KW - insecticides
KW - lambda-cyhalothrin
KW - malathion
KW - methodology
KW - naled
KW - organophosphorus insecticides
KW - permethrin
KW - pesticide synergists
KW - pyrethroids
KW - resmethrin
KW - susceptibility
KW - synergists
KW - techniques
KW - toxicity
KW - Aedes aegypti
KW - Aedes albopictus
KW - Anopheles albimanus
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Culex nigripalpus
KW - Culex pipiens
KW - Culex restuans
KW - Culex salinarius
KW - Culex territans
KW - Culicidae
KW - Diptera
KW - Lutzomyia youngi
KW - Phlebotominae
KW - Psychodidae
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Culex
KW - Psychodidae
KW - Lutzomyia
KW - Phlebotominae
KW - Asian tiger mosquito
KW - methods
KW - mosquitoes
KW - Pesticide and Drug Resistance (HH410)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506630&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Implications of calreticulin function in parasite biology.
AU - Nakhasi, H. L.
AU - Pogue, G. P.
AU - Duncan, R. C.
AU - Joshi, M.
AU - Atreya, C. D.
AU - Lee, N. S.
AU - Dwyer, D. M.
JO - Parasitology Today
JF - Parasitology Today
Y1 - 1998///
VL - 14
IS - 4
SP - 157
EP - 160
AD - Nakhasi, H. L.: Section on Viral Pathogenesis and Adverse Reactions, Division of Viral Products, OVRR, CBER, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 19980804799. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Helminthology
N2 - The identification of calreticulin protein homologues in Onchocerca, Schistosoma and Leishmania suggests that this protein has a role in enabling parasites to sense and respond to various environmental stimuli, and thus adapt to a disparate array of hosts and biochemical milieux encountered during the parasite life cycle. The structure of calreticulin and its many functions (Ca2+-binding, as a chaperone, interactions with cellular receptors, RNA binding, and in the immune response) are discussed.
KW - biochemistry
KW - helminths
KW - host parasite relationships
KW - parasites
KW - calreticulin
KW - parasite host relationships
KW - parasitic worms
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980804799&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Traditional approach preventive HIV vaccines: what are the cell substrate and inactivation issues?
AU - Sheets, R. L.
AU - Goldenthal, K. L.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1998///
VL - 14
IS - 7
SP - 627
EP - 633
SN - 0889-2229
AD - Sheets, R. L.: CBER/Food and Drug Administration, HFM-475, 1401 Rockville Pike, Rockville, MD, 20852, USA.
N1 - Accession Number: 19982008377. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 37 ref. Registry Number: 9007-49-2.
N2 - On February 14, 1996, at the Eighth Annual Meeting of the National Cooperative Vaccine Development Group for AIDS in Bethesda, MD, a workshop entitled "Traditional Approach Preventive HIV Vaccines: What Are the Cell Substrate and Inactivation Issues?" was convened. A summary of the meeting noted that, "The use of cell substrates such as tumour-derived continuous cell lines (TCLs) or virus transformed CLs may be the most feasible approach to provide commercial-scale virus yields. However, especially because of concerns about tumorigenicity, TCLs have not been used to produce preventive vaccines for human trials with healthy subjects in the USA. Residual TCL material (e.g., DNA, cellular proteins, viruses) may not be removed during purification of intact HIV virions to the same extent achievable for a recombinant protein. Manufacturing processes, e.g. physicochemical methods of destroying DNA, could decrease tumorigenicity risk. Methods to assess potential for tumorigenicity may need further development."
KW - acquired immune deficiency syndrome
KW - cell lines
KW - development
KW - DNA
KW - human diseases
KW - human immunodeficiency viruses
KW - inactivation
KW - proteins
KW - purification
KW - recombinant proteins
KW - research
KW - safety
KW - substrates
KW - vaccines
KW - USA
KW - man
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - cellular proteins
KW - deoxyribonucleic acid
KW - human immunodeficiency virus
KW - studies
KW - United States of America
KW - virions
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008377&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV peptide conjugated to heat-killed bacteria promotes antiviral responses in immunodeficient mice.
AU - Scott, D. E.
AU - Golding, H.
AU - Huang, L. Y.
AU - Inman, J.
AU - Golding, B.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 1998///
VL - 14
IS - 14
SP - 1263
EP - 1269
SN - 0889-2229
AD - Scott, D. E.: US Food and Drug Administration, Bldg 29/Rm 232, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19982013994. Publication Type: Journal Article. Language: English. Number of References: 51 ref.
N2 - The experiments reported in this paper demonstrate that a heat-inactivated bacterium such as Brucella abortus, when used as a carrier, can generate a cytokine environment that results in the production of neutralizing antiviral antibodies in an immunodeficient host. Such strategies could be important in the development of immunotherapies and vaccines for HIV-1 patients.
KW - antibodies
KW - antiviral agents
KW - cytokines
KW - hosts
KW - human diseases
KW - immune response
KW - immunological deficiency
KW - immunotherapy
KW - neutralization
KW - peptides
KW - vaccines
KW - bacteria
KW - Human immunodeficiency virus 1
KW - man
KW - mice
KW - prokaryotes
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - bacterium
KW - human immunodeficiency virus type 1
KW - immune deficiency
KW - immunity reactions
KW - immunodeficiency
KW - immunological reactions
KW - Pesticides and Drugs (General) (HH400)
KW - Host Resistance and Immunity (HH600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013994&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A highly sensitive gas chromatographic determination of levamisole in milk.
AU - Schenck, F. J.
AU - Podhorniak, L. V.
AU - Wagner, R.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1998///
VL - 15
IS - 4
SP - 411
EP - 414
SN - 0265-203X
AD - Schenck, F. J.: Food and Drug Administration, Baltimore District, 900 Madison Ave. Baltimore, MD 21201, USA.
N1 - Accession Number: 19980404084. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 14769-73-4, 16595-80-5. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science; Helminthology; Veterinary Science
N2 - Levamisole was extracted from alkaline milk with ethyl acetate. Clean-up of the extract was by a series of liquid-liquid extraction steps. Levamisole residues in the extract were determined by gas chromatography with a nitrogen-phosphorus detector. This method was satisfactory for determining levamisole residues in milk at concentrations of ≥0.5 ng/g. Mean recoveries of 0.5-10.0 ng/g fortified milk samples ranged from 84.5 to 95.2%. Five replicate analyses performed on milk containing incurred levamisole residues yielded a mean of 3.34 ng/g with a coefficient of variation of 3.0%.
KW - analytical methods
KW - anthelmintics
KW - contamination
KW - cows
KW - drug residues
KW - gas chromatography
KW - helminths
KW - levamisole
KW - milk
KW - parasites
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - parasitic worms
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980404084&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of borates in caviare by ion-exclusion chromatography.
AU - Carlson, M.
AU - Thompson, R. D.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1998///
VL - 15
IS - 8
SP - 898
EP - 905
SN - 0265-203X
AD - Carlson, M.: US Food and Drug Administration, 240 Hennepin Avenue, Minneapolis, MN 55401, USA.
N1 - Accession Number: 19991404850. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7440-42-8, 50-70-4. Subject Subsets: Human Nutrition
N2 - A specific and rapid analytical procedure for the determination of borates in caviar was developed using ion-exclusion chromatography. Products require minimal pre-treatment, are simply extracted with eluent and filtered prior to chromatography. Isolation of the analyte as a 2:1 sorbitol-borate complex was accomplished using an anion exchange column with an eluent consisting of 2 mm sorbitol, and conductivity detection was used. Among five sugar alcohols examined for complexation, sorbitol was found to provide optimum resolution and a 3-4 times enhancement of response over borate anion alone. The response of the complex was linear over at least a 100 fold range in concentration (0.1-10 µg boron/ml) with a correlation coefficient of 0.9997. Using a boric acid standard solution, the limits of detection and quantitation were 0.065 µg/ml and 0.216 µg/ml, respectively, calculated as boron. Replicate analyses (n=5) for samples having commercially added borate (equivalent to 300-1000 µg/g boron) gave RSD values of 1.18-2.03%. Recoveries of borate from fortified samples having commercially added borate present varied from 94.5 to 101.1% while untreated samples exhibited recoveries of 78.5-108.0% over a concentration range of 23-1039 µg/g, calculated as boron.
KW - analytical methods
KW - borates
KW - boron
KW - caviar
KW - chromatography
KW - food additives
KW - preservatives
KW - sorbitol
KW - analytical techniques
KW - Food Additives (QQ130)
KW - Techniques and Methodology (ZZ900)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404850&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genomic organization and evolution of the human herpesviruses.
AU - Weir, J. P.
JO - Virus Genes
JF - Virus Genes
Y1 - 1998///
VL - 16
IS - 1
SP - 85
EP - 93
SN - 0920-8569
AD - Weir, J. P.: Laboratory of DNA Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.
N1 - Accession Number: 19982007052. Publication Type: Journal Article. Language: English. Number of References: 63 ref.
N2 - The structure, organization and gene contents of the 8 human herpesviruses are compared and recent findings on their evolution summarized.
KW - evolution
KW - genes
KW - genomes
KW - human herpesviruses
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - human herpesvirus
KW - nucleotide seuqences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Size and duration of zidovudine benefit in 1003 HIV-infected patients: U. S. Army, Navy, and Air Force natural history data.
AU - Gardner, L. I.
AU - Harrison, S. H.
AU - Hendrix, C. W.
AU - Blatt, S. P.
AU - Wagner, K. F.
AU - Chung, R. C. Y.
AU - Harris, R. W.
AU - Cohn, D. L.
AU - Burke, D. S.
AU - Mayers, D. L.
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Y1 - 1998///
VL - 17
IS - 4
SP - 345
EP - 353
AD - Gardner, L. I.: Analysis and Field Evaluations Branch, Division of Safety Research, 1095 Willowdale Road, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 19982005653. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 30516-87-1.
N2 - In this study 174 of 1003 HIV-infected patients were treated with zidovudine before CD4+ counts fell to <400 × 109/l, ("early treatment"); 183 of 1003 patients were treated after CD4+ cell counts fell to <400 × 109/l but before clinical disease developed ("delayed treatment"); and 646 of the 1003 patients had either been treated after clinical disease developed or had not been treated at all by the end of follow-up ("late treatment"). The relative risk (RR) of progression for early versus delayed treatment was 0.58 (P <0.03), and durability of AZT benefits on progression was estimated at no more than 2.0 years; however, this estimate had wide confidence intervals. The RR of progression for delayed versus late treatment was 0.54, P < 0.0001, and durability of AZT benefits was estimated at 1.74 years; this estimate had narrow confidence intervals. Survival was better for the early versus delayed treatment (RR = 0.55), but this difference was not statistically significant. In the subgroup of patients with more rapid CD4+ cell decline prior to AZT therapy, significant benefits on progression were observed for early versus delayed AZT therapy (RR = 0.42, P = 0.02) and delayed versus late AZT therapy (RR = 0.51; P = 0.0004). Duration of benefit was estimated to be 4.5 years (early versus delayed) and 1.7 years (delayed versus late). For patients with less rapid pre-AZT decline in CD4+ cell levels, a significant progression benefit was observed for delayed versus late therapy (RR = 0.50; P = 0.02). Duration of benefit in this subgroup was estimated to be 1.8 years. No significant benefit was found for early versus delayed treatment (RR = 1.12 years) in the less rapid pre-AZT CD4+ cell decline subgroup.
KW - antiviral agents
KW - CD4+ lymphocytes
KW - clinical trials
KW - disease course
KW - human immunodeficiency viruses
KW - leukocyte count
KW - mortality
KW - survival
KW - treatment
KW - zidovudine
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - AZT
KW - CD4+ cells
KW - cell count
KW - death rate
KW - disease progression
KW - human immunodeficiency virus
KW - T4 lymphocytes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982005653&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concentration- and time-dependent upregulation and release of the cytokines MIP-2, KC, TNF, and MIP-1α in rat alveolar macrophages by fungal spores implicated in airway inflammation.
AU - Shahan, T. A.
AU - Sorenson, W. G.
AU - Paulauskis, J. D.
AU - Morey, R.
AU - Lewis, D. M.
JO - American Journal of Respiratory Cell and Molecular Biology
JF - American Journal of Respiratory Cell and Molecular Biology
Y1 - 1998///
VL - 18
IS - 3
SP - 435
EP - 440
SN - 1044-1549
AD - Shahan, T. A.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.
N1 - Accession Number: 19981202731. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 308079-78-9. Subject Subsets: Medical & Veterinary Mycology
N2 - Biochemical and molecular markers of inflammation were measured in rat bronchial alveolar lavage cells (>95% macrophages) following stimulation with fungal spores from pathogenic and non-pathogenic fungi that have been implicated in airway inflammation. mRNA transcripts for the C-X-C branch of the PF4 superfamily were differentially upregulated over those of the C-C mediators in a time- and concentration-dependent manner. Macrophage inflammatory protein (MIP)-2 and KC were differentially upregulated over the acute phase inflammatory cytokines MIP-1α and tumour necrosis factor-α (TNF-α) in rat alveolar macrophages stimulated with fungal spores from Aspergillus candidus, A. niger, Eurotium amstelodami and Cladosporium cladosporioides. Spores from A. terreus and Penicillium spinulosum failed to stimulate an increase in any cytokine mRNA, whereas those from A. fumigatus stimulated the upregulation of MIP-2, KC, TNF-α and MIP-1α mRNAs. Over time, A. fumigatus stimulated increasing KC production until 24 h, when production levels increased slightly, then levelled off when measurements ceased at 36 h. Latex spheres stimulated modest amounts of MIP-2 and transforming growth factor-β only. It is suggested that the inflammatory cytokines MIP-2 and KC may be involved in the inflammation arising from the inhalation of fungal spores in a time- and concentration-dependent manner.
KW - allergies
KW - cytokines
KW - immune response
KW - inflammation
KW - lungs
KW - macrophages
KW - tumour necrosis factor
KW - Aspergillus candidus
KW - Aspergillus fumigatus
KW - Aspergillus niger
KW - Cladosporium cladosporioides
KW - Mycosphaerellaceae
KW - rats
KW - Trichocomaceae
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Cladosporium
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Eurotium
KW - Mycosphaerella
KW - Mycosphaerellaceae
KW - cachectin
KW - cachexin
KW - Eurotium amstelodami
KW - fungus
KW - Hyphomycetes
KW - immunity reactions
KW - immunological reactions
KW - Mycosphaerella tassiana
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats.
AU - Harris, A. J.
AU - Shaddock, J. G.
AU - Manjanatha, M. G.
AU - Lisenbey, J. A.
AU - Casciano, D. A.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1998///
VL - 19
IS - 8
SP - 1451
EP - 1458
SN - 0143-3334
AD - Harris, A. J.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991200195. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Registry Number: 9035-51-2, 50812-37-8, 11096-37-0. Subject Subsets: Medical & Veterinary Mycology
N2 - Three polymerase chain reaction (PCR)-based subtractive techniques were used to identify aflatoxin B1 (AFB1)-responsive genes in cultured primary rat hepatocyte RNA: differential display PCR (DD-PCR), representational difference analysis (RDA) and suppression subtractive hybridization (SSH). Each of the techniques identified AFB1-responsive genes, although no individual cDNA was isolated by more than one technique. Nine cDNAs isolated using DD-PCR, RDA or SSH were found to represent 8 genes that are differentially expressed as a result of AFB1 exposure. Genes whose mRNA levels were increased in cultured primary rat hepatocytes after AFB1 treatment were corticosteroid binding globulin (CBG), cytochrome P450 4F1 (CYP4F1), alpha-2 microglobulin, C4b-binding protein (C4BP), serum amyloid A-2 and glutathione S-transferase Yb2 (GST). Transferrin and a small CYP3A-like cDNA had reduced mRNA levels after AFB1 exposure. Full-length CYP3A mRNA levels were increased. When liver RNA from AFB1-treated male F344 rats was evaluated for transferrin, CBG, GST, CYP3A and CYP4F1 expression, a decrease in transferrin mRNA and an increase in CBG, GST, CYP3A and CYP4F1 mRNA levels was also seen. Analysis of the potential function of these genes in maintaining cellular homeostasis indicated that their differential expression could contribute to the toxicity associated with AFB1 exposure.
KW - aflatoxicosis
KW - aflatoxins
KW - carcinogenesis
KW - complementary DNA
KW - cytochrome P-450
KW - genes
KW - glutathione transferase
KW - identification
KW - liver
KW - liver cells
KW - mycotoxins
KW - poisoning
KW - toxicity
KW - transferrin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin poisoning
KW - cDNA
KW - fungal toxins
KW - hepatocytes
KW - ligandin
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200195&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets.
AU - Lopatina, N. G.
AU - Vanyushin, B. F.
AU - Cronin, G. M.
AU - Poirier, L. A.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 1998///
VL - 19
IS - 10
SP - 1777
EP - 1781
SN - 0143-3334
AD - Lopatina, N. G.: Division of Nutritional Toxicology, National Center for Toxicological Research, NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991404336. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - DNA methyltransferase (MTase) activity in nuclear extracts from neoplastic and preneoplastic livers of rats fed a methyl-deficient diet (MDD) was increased compared with that seen in the livers of control rats. Nuclear proteins were prepared in the presence of protease inhibitors including trans-epoxy succinyl-L-leucylamido-(4-guanido)butane and were fractionated by isoelectric focusing. In normal, control liver, 2 distinct MTase fractions were observed. In MDD-induced malignant liver, a third fraction, in addition to the previous two, was also seen. Both the DNA substrate and the cytosine site specificities of the third MTase fraction differ from those of the other two fractions. The distinct MTase activity in liver tumour has significantly more de novo MTase activity than do the MTase fractions of normal, control liver. Normal and neoplastic rat livers differ in DNA MTase fractionation patterns and site specificities. The altered DNA MTase activity observed in rat liver tumours caused by MDDs may be one of the critical factors contributing to cancer formation through abnormal DNA methylation.
KW - carcinogenesis
KW - deficiency
KW - DNA
KW - enzyme activity
KW - gene expression
KW - lipotropic factors
KW - liver
KW - neoplasms
KW - tumours
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - deoxyribonucleic acid
KW - lipotropes
KW - tumors
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404336&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cytokine mRNA levels in the hearts of inbred mice that develop different degrees of cardiomyopathy during infection with Trypanosoma cruzi.
AU - Powell, M. R.
AU - Morgan, J.
AU - Guarner, J.
AU - Colley, D. G.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 1998///
VL - 20
IS - 10
SP - 463
EP - 471
SN - 0141-9838
AD - Powell, M. R.: Immunology Branch, Division of Parasitic Diseases, National Institute for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Mailstop F-13, 4770 Buford Highway, NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19990800611. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 207137-56-2, 308079-78-9, 148157-34-0. Subject Subsets: Protozoology
N2 - Profiles of cytokine mRNA expression were examined by semiquantitative RT-PCR in the hearts of DBA/2 (pathopermissive) and B10.D2 (pathoresistant) mice during infection with the Brazil strain of Trypanosoma cruzi. The levels and time-course profiles of IFNγ, IL-1β and IL-10 mRNA expression were similar in each strain. TNFα, iNOs, and IL-13 mRNA expression peaked at comparable levels and times after infection in each strain, but declined more rapidly in B10.D2 than in DBA/2 mice. Peak IL-2 mRNA levels were also similar in the 2 strains, but occurred earlier in DBA/2 than in B10.D2 mice. Levels of IL-4, IL-6 and IL-12 mRNA were significantly higher in DBA/2 than in B10.D2 mice from day 10 through day 50 of infection. With the exception of IL-1β, which was expressed constitutively in both strains, the levels of mRNA of all other cytokines examined reached their peak no later than day 20 and declined significantly by day 50 pi. The inflammatory infiltrate paralleled the latter cytokines; starting at day 10 in DBA/2 mice and at day 15 in the B10.D2 mice, peaking between days 20 and 30 in both strains, decreasing to minimal levels by day 50 in the pathoresistant mice, but maintaining a mild amount through day 70 in the pathopermissive strain. The inflammation was composed mostly of lymphocytes and histiocytes throughout the entire process.
KW - cardiomyopathy
KW - cytokines
KW - experimental infections
KW - heart
KW - immunopathology
KW - interferon
KW - interleukin 1
KW - interleukin 10
KW - interleukin 12
KW - interleukin 13
KW - interleukin 2
KW - interleukin 4
KW - interleukin 6
KW - laboratory animals
KW - parasites
KW - tumour necrosis factor
KW - mice
KW - protozoa
KW - Trypanosoma cruzi
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - cachectin
KW - cachexin
KW - immunopathogenesis
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990800611&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pharmacokinetics of phenylbutazone in plasma and milk of lactating dairy cows.
AU - Veau, E. J. I. de
AU - Pedersoli, W.
AU - Cullison, R.
AU - Baker, J.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 1998///
VL - 21
IS - 6
SP - 437
EP - 443
SN - 0140-7783
AD - Veau, E. J. I. de: Division of Residue Chemistry, Center for Veterinary Medicine (CVM), Office of Research (OR), 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19992201801. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 50-33-9. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - Groups of 4 lactating cows were given phenylbutazone (6 mg/kg i.v.) and whole plasma, protein-free plasma and milk were examined for phenylbutazone residues. Pharmacokinetic parameters of total and free phenylbutazone in plasma were calculated using a non-compartmental method. The mean volume of distribution at steady state (Vss), was 147 ml/kg, with a mean (± SEM) terminal elimination half-life (t0.5) of 40 ± 6 h. The mean clearance (Cl) was 3 ml/h/kg body weight. The Vss measured in the protein-free plasma fraction was 50 021 ml/kg body weight. This larger Vss of free phenylbutazone compared to total plasma phenylbutazone was attributed to a high degree of plasma protein binding, as well as the greater penetration of free phenylbutazone into tissues. The mean t0.5 of free phenylbutazone was 39 ± 5 h. This similarity to the t0.5 estimated from total plasma phenylbutazone data is attributed to an equilibrium between free and plasma phenylbutazone during the terminal elimination phase. Mean t0.5 as measured from milk, applying a urinary excretion rate model, was 47 ± 4 h. Milk clearance of phenylbutazone was 0.009 ml/h/kg body weight, or about 0.34% of total body clearance. Evidence suggests that phenylbutazone either binds to milk proteins, or is actively transported into milk, as its concentration in milk was greater than that predicted due to a simple partitioning from plasma into milk.
KW - dairy cattle
KW - drug residues
KW - milk
KW - pharmacokinetics
KW - phenylbutazone
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992201801&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for the analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in soy based infant formula using matrix solid phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1998///
VL - 21
IS - 18
SP - 2853
EP - 2861
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St., Atlanta, GA 30309, USA.
N1 - Accession Number: 19991400869. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 59-02-9, 68-26-8, 79-81-2, 1406-18-4. Subject Subsets: Human Nutrition; Soyabeans
N2 - All-rac-α-tocopheryl acetate and retinyl palmitate were extracted from infant formula without saponification by matrix solid phase dispersion (MSPD) and quantitated by normal phase chromatography with fluorescence detection. They were then quantitated isocratically with a mobile phase of hexane containing isopropanol at 0.125% (v/v) and 0.5% (v/v), respectively. Results compared favourably with the label declaration on a retail infant formula product. Recoveries were determined on a soya-based zero control reference material (ZRM) fortified with the analytes for soya-based infant formula and averaged 99.0% (n=30) for retinyl palmitate and 97.1% (n=25) for all-rac-α-tocopheryl acetate. Five concentrations were examined for each analyte and the results were linear (r²=0.998) over the concentration examined with CVs of 1.24-5.44%. It is concluded that the method provides a rapid, specific and easily controlled assay approach for the analysis of retinyl palmitate and all-rac-α-tocopheryl acetate in fortified soya-based infant formula. The cost per analysis at present market value of expendables when using MSPD was $3-4. It was concluded that the MSPD technique is efficient and highly cost effective.
KW - alpha-tocopherol
KW - analytical methods
KW - assays
KW - chromatography
KW - infant formulae
KW - retinol
KW - retinyl palmitate
KW - soya milk
KW - vitamin E
KW - analytical techniques
KW - axerophthol
KW - infant formula
KW - infant formulas
KW - retinol palmitate
KW - soy milk
KW - soyabean milk
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400869&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health implications of persistent toxic substances in the Great Lakes and St. Lawrence basins.
AU - Johnson, B. L.
AU - Hicks, H. E.
AU - Jones, D. E.
AU - Cibulas, W.
AU - Wargo, A.
AU - Rosa, C. T. de
JO - Journal of Great Lakes Research
JF - Journal of Great Lakes Research
Y1 - 1998///
VL - 24
IS - 3
SP - 698
EP - 722
SN - 0380-1330
AD - Johnson, B. L.: U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substance and Disease Registry, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19992012631. Publication Type: Journal Article. Language: English. Number of References: 6 pp. of ref. Registry Number: 7439-97-6. Subject Subsets: Leisure, Recreation, Tourism; Soils & Fertilizers; Irrigation & Drainage
N2 - This paper summarizes the primary literature and reviews research findings of the health implications associated with exposure to persistent toxic substances (PTSs) in the Great Lakes and St. Lawrence River basins. Most of these studies focus on fish consumption because this route has been shown to be the major route of exposure to PTSs; however, other exposure routes including air, diet and water are also important. Recent studies complement and build upon the epidemiological, wildlife and laboratory data gathered over the last 3 decades documenting health consequences associated with PTSs. For example, findings in the USA indicate that at-risk populations, e.g. certain ethnic groups, sport anglers, the elderly, pregnant women, children, fetuses and nursing infants, continue to be exposed to PTSs including PCBs, dioxins, chlorinated pesticides and mercury. The human health data for these groups indicate that: reproductive function may be disrupted by exposure to PCBs and other PTSs; neurobehavioural and developmental deficits occur in newborns and continue through school-age children from in utero exposure to PCBs and other PTSs; and other systemic effects, e.g., self-reported liver disease and diabetes, may be associated with elevated serum levels of PCBs. Other conclusions include: the benefits from fish consumption should be considered when evaluating health implications of fish consumption; health education is especially valuable in mitigating potential effects and informing individuals about certain windows of vulnerability, e.g., pregnancy; and pollution prevention strategies remain a key to reducing toxic chemical loading.
KW - children
KW - dioxins
KW - fish
KW - fish consumption
KW - lakes
KW - mercury
KW - neonates
KW - pesticides
KW - polluted water
KW - pollution
KW - polychlorinated biphenyls
KW - pregnancy
KW - public health
KW - reproduction
KW - reviews
KW - risk groups
KW - toxic substances
KW - toxicology
KW - water pollution
KW - North America
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - environmental pollution
KW - gestation
KW - newborn infants
KW - PCBs
KW - poisons
KW - Education, Extension, Information and Training (General) (CC000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Health Services (UU350)
KW - Pesticides and Drugs (General) (HH400)
KW - Pollution and Degradation (PP600)
KW - Biological Resources (Animal) (PP710)
KW - Women (UU500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012631&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rhabdomyolysis in human immunodeficiency virus-positive patients taking trimethoprim-sulfamethoxazole.
AU - Singer, S. J.
AU - Racoosin, J. A.
AU - Viraraghavan, R.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1998///
VL - 26
IS - 1
SP - 233
EP - 234
SN - 1058-4838
AD - Singer, S. J.: Food and Drug Administration, 9201 Corporate Boulevard, Rm S-130, Rockville, MD 20850, USA.
N1 - Accession Number: 19982001972. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 8064-90-2.
KW - acquired immune deficiency syndrome
KW - adverse effects
KW - co-trimoxazole
KW - human diseases
KW - human immunodeficiency viruses
KW - muscles
KW - myoglobinuria
KW - rhabdomyolysis
KW - treatment
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - AIDS
KW - human immunodeficiency virus
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982001972&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Two-year review of hepatitis A vaccine safety: data from the Vaccine Adverse Event Reporting System (VAERS).
AU - Niu, M. T.
AU - Salive, M.
AU - Krueger, C.
AU - Ellenberg, S. S.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1998///
VL - 26
IS - 6
SP - 1475
EP - 1476
SN - 1058-4838
AD - Niu, M. T.: Division of Biostatistics and Epidemiology, Office of Establishment Licensing and Product Surveillance, Center for Biologic Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19982011556. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health
KW - adverse effects
KW - data collection
KW - hepatitis A
KW - human diseases
KW - immunization
KW - safety
KW - vaccination
KW - vaccines
KW - viral diseases
KW - viral hepatitis
KW - USA
KW - hepatitis A virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - data logging
KW - immune sensitization
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011556&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studying transmission of tuberculosis with use of DNA fingerprinting.
AU - Doveren, R. F. C.
AU - Keizer, S. T.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1998///
VL - 27
IS - 2
SP - 412
EP - 413
SN - 1058-4838
AD - Doveren, R. F. C.: Regional Public Health Service Zeeland, Goes, Netherlands.
N1 - Accession Number: 19982013228. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
KW - disease transmission
KW - DNA fingerprinting
KW - human diseases
KW - methodology
KW - tuberculosis
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - methods
KW - spoligotyping
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013228&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory action criteria for filth and other extraneous materials: I. Review of hard or sharp foreign objects as physical hazards in food.
AU - Olsen, A. R.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1998///
VL - 28
IS - 3
SP - 181
EP - 189
SN - 0273-2300
AD - Olsen, A. R.: US Food and Drug Administration, Microanalytical Branch, HFS-315, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19990506379. Publication Type: Journal Article. Language: English. Number of References: 2 pp. of ref.
N2 - This review includes sections entitled: methodology; overview of the literature; reported frequency and kinds of injury from ingested hard or sharp objects; reported kinds and sizes of hard or sharp objects in food; Food and Drug Administration [USA] Health Hazard Evaluation Board (HHEB) decisions; overview of HHEB health hazard evaluations; health hazard evaluations of glass objects; health hazard evaluations of metal objects; health hazard evaluations of plastic objects; health hazard evaluations wood objects; health hazard evaluations other objects; size criteria for hard foreign objects; comparisons between federal agencies; hazard analysis critical control point.
KW - food
KW - food contamination
KW - glass
KW - hazards
KW - ingestion
KW - injuries
KW - legislation
KW - metals
KW - plastics
KW - wood
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Human Injuries (VV610) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506379&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory action criteria for filth and other extraneous materials: II. Allergenic mites: an emerging food safety issue.
AU - Olsen, A. R.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1998///
VL - 28
IS - 3
SP - 190
EP - 198
SN - 0273-2300
AD - Olsen, A. R.: Microanalytical Branch, HFS-315, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, Southwest, Washington, DC 20204, USA.
N1 - Accession Number: 19990506380. Publication Type: Journal Article. Language: English. Number of References: 3 pp. of ref. Registry Number: 37341-29-0, 308067-57-4. Subject Subsets: Medical & Veterinary Entomology
N2 - This review identifies 4 species of mites as food contamination problems: Dermatophagoides farinae, Suidasia sp., Thyreophagus entomophagus and Tyrophagus putrescentiae. These can lead to IgE-mediated allergic reactions in persons eating contaminated food. Sections are entitled: methodology; summary of literature reports; intestinal acariasis; oral allergy; anaphylaxis; medical importance of allergenic mites: evidence for IgE-mediation; allergenic mite species that contaminate food; taxonomies and identification; allergenicity thresholds for food-contaminating mites; cross-reactivity; seafood.
KW - allergies
KW - anaphylaxis
KW - arthropod allergies
KW - cross reaction
KW - food
KW - food allergies
KW - food contamination
KW - food safety
KW - house dust mites
KW - human diseases
KW - IgE
KW - immunoglobulins
KW - reviews
KW - seafoods
KW - Acari
KW - Acaridae
KW - Dermatophagoides farinae
KW - man
KW - mites
KW - Suidasia
KW - Tyrophagus putrescentiae
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Astigmata
KW - mites
KW - Acari
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Winterschmidtiidae
KW - Tyrophagus
KW - Acaridae
KW - acariasis
KW - anaphylactic reactions
KW - anaphylactic shock
KW - food contaminants
KW - food hypersensitivity
KW - gamma-globulins
KW - house-dust mites
KW - housedust mites
KW - immune globulins
KW - reagin
KW - reaginic antibodies
KW - Thyreophagus
KW - Thyreophagus entomophagus
KW - Tyroglyphidae
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506380&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory action criteria for filth and other extraneous materials: III. Review of flies and foodborne enteric disease.
AU - Olsen, A. R.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1998///
VL - 28
IS - 3
SP - 199
EP - 211
SN - 0273-2300
AD - Olsen, A. R.: Microanalytical Branch, HFS-315, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, Southwest, Washington, DC 20204, USA.
N1 - Accession Number: 19990506381. Publication Type: Journal Article. Language: English. Number of References: 4 pp. of ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This review indicates that 21 of the 47 species of flies associated with 'filthy conditions' that might allow transmission of foodborne pathogens pose a threat to human health as agents of intestinal myiasis or carriers of pathogens such as Escherichia coli, Salmonella or Shigella. Sections are entitled: methodology; intestinal myiasis; the fly as a carrier of disease; effects on morbidity of controlling fly populations; risk assessment studies; transmission of pathogens by flies; interpreting the bionomic data; interpreting the epidemiological data; revisiting the concept of a 'filth fly'; filth flies in the Hazard Analysis and Critical Control Point environment; conclusions: regulatory significance of flies.
KW - disease transmission
KW - disease vectors
KW - foodborne diseases
KW - human diseases
KW - myiasis
KW - reviews
KW - Anthomyiidae
KW - Calliphoridae
KW - Diptera
KW - Escherichia coli
KW - man
KW - Muscidae
KW - Otitidae
KW - Piophilidae
KW - Salmonella
KW - Sarcophagidae
KW - Scathophagidae
KW - Sepsidae
KW - Shigella
KW - Sphaeroceridae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - E. coli
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506381&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Carotene uptake and effects on intracellular levels of retinol in vitro.
AU - Wei RongRong
AU - Wamer, W. G.
AU - Lambert, L. A.
AU - Kornhauser, A.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1998///
VL - 30
IS - 1
SP - 53
EP - 58
SN - 0163-5581
AD - Wei RongRong: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-128, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001412669. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7235-40-7, 68-26-8. Subject Subsets: Human Nutrition
N2 - The purpose of the present study was to determine β-carotene uptake and resultant effects on intracellular levels of retinol in cell lines of varied origin. Human skin fibroblasts, mouse embryonic fibroblasts, rabbit corneal epithelial cells, and rat liver cells were studied. Cells were cultured in medium supplemented with β-carotene in a water-dispersible beadlet formulation. At selected intervals, cells and media were sampled and analysed by high-performance liquid chromatography for β-carotene and retinol content. β-Carotene was taken up by all four cell lines. An increase in the intracellular levels of retinol was concomitant with β-carotene uptake in all cell lines. The uptake of β-carotene and the increase in intracellular retinol were highest in the two fibroblast cell lines. Incubation with media supplemented with crystalline β-carotene, dissolved in tetrahydrofuran, resulted in significantly lower β-carotene uptake and intracellular retinol levels. It is suggested that these results are a demonstration that a wide variety of cells, cultured in vitro, are able to convert β-carotene to retinol. Therefore, β-carotene's provitamin A activity should be carefully considered when the protective effects of β-carotene in vitro are interpreted.
KW - beta-carotene
KW - cell cultures
KW - cell lines
KW - fibroblasts
KW - in vitro
KW - liver cells
KW - retinol
KW - uptake
KW - axerophthol
KW - hepatocytes
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412669&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative contribution of calories from dietary fat, carbohydrate, and fiber in the promotion of DMBA-induced mammary tumors in Sprague-Dawley rats.
AU - Jackson, C. D.
AU - Weis, C.
AU - Chen, J. J.
AU - Bechtel, D. H.
AU - Poirier, L. A.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1998///
VL - 30
IS - 3
SP - 194
EP - 200
SN - 0163-5581
AD - Jackson, C. D.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20001412826. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - It is well known that caloric restriction inhibits, whereas excess calories promote, mammary tumorigenesis in rats. However, the relative contributions to carcinogenesis by calories derived from fat or from carbohydrate are not well established. To determine the relative effects of calories from fat or from carbohydrate, as well as any interaction of dietary fibre on the promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumours, nine isocaloric diets containing different ratios of fat, carbohydrate, and fibre were fed to female Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene (30/group). Under conditions of isocaloric consumption, at or near ad libitum feeding, calories from dietary fat had an approximately two-fold greater promoting effect on final body weight and tumour incidence than calories derived from dietary carbohydrate. Dietary fibre had an inhibitory effect on tumour development, but the effect was evident only in the high-fat groups. Logistic regression analysis of tumour incidence gave β-coefficient estimates for the relative effects of fat, carbohydrate, and fibre of 0.866, 0.189, and -4.281, respectively. Time-to-tumour analysis by the Weibull model indicated β-estimates of 3.016, 3.324, and 5.825 for dietary fat, carbohydrate, and fibre, respectively, indicating that fat shortens and fibre increases the length of time to tumour. The statistical model derived from these results also indicates a significant synergistic interaction of dietary fat and carbohydrate on final body weight and tumour incidence.
KW - carbohydrates
KW - carcinogenesis
KW - dietary carbohydrate
KW - dietary fat
KW - energy intake
KW - fat
KW - fats
KW - fibre
KW - mammary gland neoplasms
KW - neoplasms
KW - rat feeding
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - fiber
KW - mammary tumour
KW - saccharides
KW - source fat
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412826&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumers' ability to perform tasks using nutrition labels.
AU - Levy, A. S.
AU - Fein, S. B.
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
Y1 - 1998///
VL - 30
IS - 4
SP - 210
EP - 217
SN - 0022-3182
AD - Levy, A. S.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19991415748. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Human Nutrition
N2 - Consumers' ability to perform common nutrition label use tasks and specific task components, which revealed the effect of prior knowledge, were analysed for relationships with demographic characteristics, label reading, and health status. Data were from a mall intercept experimental study. Most consumers (78%) accurately compared 2 products, 58% accurately evaluated nutrient level claims, 45% comprehensively balanced nutrients over a daily diet, and 20% accurately calculated the contribution of a single food to a daily diet, a task that required complex math. The subjects who performed significantly poorer were over 55 years of age, non-white, and less educated than those who performed best. Not reading food labels and having a diet-related health condition were also related to poorer performance. Task component analysis showed that all types of subjects shared the same response tendencies when making nutrition judgments. It is concluded that dietary guidance for consumers will be more effective if it does not require quantitative tasks but relies instead on tasks that are easier for consumers.
KW - consumers
KW - diet
KW - foods
KW - labelling
KW - nutrients
KW - nutrition
KW - nutrition knowledge
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415748&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers.
AU - Sehat, N.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Ku, Y.
JO - Lipids
JF - Lipids
Y1 - 1998///
VL - 33
IS - 2
SP - 217
EP - 221
SN - 0024-4201
AD - Sehat, N.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19981408600. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 60-33-3. Subject Subsets: Human Nutrition; Dairy Science
N2 - The application of silver-ion impregnated HPLC (Ag+-HPLC) to the separation of complex mixtures of conjugated linolenic acid (CLA) isomers present in commercial CLA sources, foods and biological specimens is described. This method showed a clear separation of CLA isomers into 3 groups related to their trans,trans, cis,trans or trans,cis, and cis,cis configuration of the conjugated double-bond system. In addition, this method separated individual positional isomers of the conjugated diene system within each geometrical isomeric group. Following Ag+-HPLC isolation, gas chromatography (GC)-electron impact mass spectrometry, and GC-direct deposition-Fourier transformed infrared spectroscopy were used to confirm the identity of two major positional isomers in the cis/trans region, i.e., Δ8,10- and Δ11,13-octadecadienoic acids, which had not been chromatographically resolved previously. Furthermore, the potential of this method was demonstrated by showing different Ag+-HPLC profiles exhibiting patterns of isomeric distributions for biological specimens from pigs fed a diet containing a commercial CLA preparation, as well as for a commercial cheese product.
KW - analytical methods
KW - cheeses
KW - diet
KW - food supplements
KW - foods
KW - HPLC
KW - identification
KW - intake
KW - isomers
KW - linoleic acid
KW - polyenoic fatty acids
KW - separation
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - high performance liquid chromatography
KW - hogs
KW - polyunsaturated fatty acids
KW - separating
KW - swine
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408600&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effect of food restriction on the composition of intestinal microflora in rats.
AU - Henderson, A. L.
AU - Cao WeiWen
AU - Wang RongFu
AU - Lu MingHsiung
AU - Cerniglia, C. E.
JO - Experimental Gerontology
JF - Experimental Gerontology
Y1 - 1998///
VL - 33
IS - 3
SP - 239
EP - 247
SN - 0531-5565
AD - Henderson, A. L.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19981408848. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - The effect of a food-restricted diet on the faecal microflora of rats was studied by determining total anaerobic bacteria, bacterial cellular fatty acids and the predominant intestinal bacteria shown by polymerase chain reaction (PCR) primers specific for the 16S rRNA gene sequences of 12 bacterial species. Female Fischer 344 rats (n=24) aged 57 days were divided into 2 groups and maintained on an NIH-31 diet. One group was fed ad libitum while the other group received 60% of ad libitum food intake (40% food restriction supplemented with vitamins and minerals equal to the ad libitum rats). After 2, 10 and 20 weeks on this dietary regimen, groups of 4 rats were sacrificed and the intestinal contents analysed for changes in the bacterial flora. The anaerobic population for 2-week (short-term) food-restricted rats was 3.2 × 108/g, slightly less than the 9.1 × 108/g in the ad libitum-fed rats. The anaerobic populations in 20-week food restricted and ad libitum fed rats were 1.9 × 109 and 2.7 × 109/g, respectively. The total anaerobic population did not change significantly in either group during the 20-week study. No significant differences were observed in the bacterial cellular fatty acid profiles between the 2 groups as determined by gas-liquid chromatography. PCR analysis of the intestinal contents indicated no significant shifts in the predominant flora due to dietary changes. The results, using 3 different methods to detect changes in the rat intestinal microflora, suggest that long-term dietary restriction had little effect on the microflora of female Fischer 344 rats.
KW - composition
KW - faecal flora
KW - food restriction
KW - intestinal microorganisms
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fecal flora
KW - gut flora
KW - intestinal micro-organisms
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408848&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A new conjugated linoleic acid isomer, 7 trans, 9 cis-octadecadienoic acid, in cow milk, cheese, beef and human milk and adipose tissue.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - Sehat, N.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Fritsche, J.
AU - Steinhart, H.
AU - Youh Ku
JO - Lipids
JF - Lipids
Y1 - 1998///
VL - 33
IS - 8
SP - 803
EP - 809
SN - 0024-4201
AD - Yurawecz, M. P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19981415539. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 60-33-3, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Dairy Science
N2 - The 7 trans, 9 cis-18:2 isomer was resolved chromatographically as the methyl ester by Ag+-HPLC; it eluted after the major 9 cis, 11 trans-18:2 isomer (rumenic acid) in the natural products analysed. In the biological matrices investigated by Ag+-HPLC, the 7 trans, 9 cis-18:2 peak was generally due to the most abundant minor conjugated linoleic acid (CLA) isomer, ranging in concentration from 3 to 16% of total CLA. By GC with long polar capillary columns, the methyl ester of 7 trans, 9 cis-18:2 was shown to elute near the leading edge of the major 9 cis, 11 trans-18:2 peak, while the 4,4-dimethyloxazoline (DMOX) derivative permitted partial resolution of these two CLA isomers. The DMOX derivative of this new CLA isomer was analysed by GC-electron ionization MS (GC-EIMS). The double bond positions were at Δ7 and Δ9 as indicated by the characteristic mass spectral fragment ions at m/z 168, 180, 194 and 206, and their allylic cleavages at m/z 154 and 234. The cis/trans double-bond configuration was established by GC-direct deposition-Fourier transform infrared as evidenced from the doublet at 988 and 949 cm-1 and absorptions at 3020 and 3002 cm-1. The 7 trans, 9 cis-18:2 configuration was established by GC-EIMS for the DMOX derivative of the natural products examined, and by comparison to a similar product obtained from treatment of a mixture of methyl 8-hydroxy- and 11-hydroxyoctadec-9 cis enoates with BF3 in methanol.
KW - adipose tissue
KW - beef
KW - cheeses
KW - composition
KW - conjugated linoleic acid
KW - human milk
KW - isomers
KW - linoleic acid
KW - milk
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breast milk
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Physiology of Human Nutrition (VV120)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415539&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of conjugated linoleic acid isomers in cheese by gas chromatography, silver ion high performance liquid chromatography and mass spectral reconstructed ion profiles. Comparison of chromatographic elution sequences.
AU - Najibullah Sehat
AU - Kramer, J. K. G.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - Eulitz, K.
AU - Morehouse, K. M.
AU - Youh Ku
JO - Lipids
JF - Lipids
Y1 - 1998///
VL - 33
IS - 10
SP - 963
EP - 971
SN - 0024-4201
AD - Najibullah Sehat: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19990400398. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 60-33-3. Subject Subsets: Dairy Science; Human Nutrition
N2 - Commercial cheese products were analysed for their composition and content of conjugated linoleic acid (CLA) isomers. The total lipids were extracted from cheese using petroleum ether/diethyl ether and methylated using NaOCH3. The fatty acid methyl esters (FAME) were separated by gas chromatography (GC), using a 100-m polar capillary column, into 9 minor peaks besides that of the major rumenic acid, 9 c,11 t-octadecadienoic acid (18:2), and were attributed to 19 CLA isomers. By using silver ion-HPLC (Ag+-HPLC), CLA isomers were resolved into 7 trans,trans (5-9%), 3 cis/trans (10-13%), and 5 cis,cis (<1%) peaks, totalling 15, in addition to that of the 9 c,11 t-18:2 (78-84%). The FAME of total cheese lipids were fractionated by semi-preparative Ag+-HPLC and converted to their 4,4-dimethyl-oxazoline derivatives after hydrolysis to free fatty acids. The geometrical configuration of the CLA isomers was confirmed by GC-direct deposition-Fourier transform infrared, and their double bond positions were established by GC-electron ionization mass spectrometry. Reconstructed mass spectral ion profiles of the m + 2 allylic ion and the m + 3 ion (where m is the position of the second double bond in the parent conjugated fatty acid) were used to identify the minor CLA isomers in cheese. Cheese contained 7 t,9c-18:2 and the previously unreported 11 t,13 c-18:2 and 12 c,14 t-18:2, and their trans,trans and cis,cis geometric isomers. Minor amounts of 8,10- and 10,12-18:2 were also found. The predicted elution orders of the different CLA isomers on long polar capillary GC and Ag+-HPLC columns are also presented.
KW - analytical methods
KW - cheeses
KW - composition
KW - esters
KW - fatty acids
KW - gas chromatography
KW - HPLC
KW - isomers
KW - linoleic acid
KW - lipids
KW - mass spectrometry
KW - milk fat
KW - analytical techniques
KW - butterfat
KW - high performance liquid chromatography
KW - lipins
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990400398&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evolution and dietary restriction.
AU - Hart, R. W.
AU - Turturro, A.
JO - Experimental Gerontology
JF - Experimental Gerontology
Y1 - 1998///
VL - 33
IS - 1/2
SP - 53
EP - 60
SN - 0531-5565
AD - Hart, R. W.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19981403870. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The evolutionary roles which dietary restriction (DR) might play in extending survival and reproductive lifespan are reviewed in relation to understanding the evolution of senescence. A series of changes resulting from DR, and influencing survival include: the reduction of energy-intensive non-food gathering activities, increased ability to extract energy from foods, increased food acquisition activity, lengthened reproductive lifespan of an animal and the improvement of processes important for genomic integrity (including DNA excision repair). Adaptive techniques used during food shortages (including the inhibition of non-essential functions) and various evolutionary changes are discussed.
KW - aging
KW - evolution
KW - food deprivation
KW - genes
KW - hibernation
KW - lifespan
KW - reproduction
KW - restricted feeding
KW - reviews
KW - senescence
KW - survival
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981403870&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance for nonfatal work-related injuries in Alaska, 1991-1995.
AU - Husberg, B. J.
AU - Conway, G. A.
AU - Moore, M. A.
AU - Johnson, M. S.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 1998///
VL - 34
IS - 5
SP - 493
EP - 498
SN - 0271-3586
AD - Husberg, B. J.: Division of Safety Research, National Institute for Occupational Safety and Health, Anchorage, AK 99508, USA.
N1 - Accession Number: 19992007331. Publication Type: Journal Article. Language: English. Number of References: 19 ref.
N2 - This article reports recent surveillance results for hospitalized nonfatal work-related injuries in Alaska, using the population-based Alaska Trauma Registry (ATR) during 1991-95. The fishing, construction and logging industries led with the highest number of reported cases in the ATR. Workers in the logging, water transportation and wood product manufacturing industries had the highest injury rates. Cause, severity, type and body region of injury were examined for each target industry. For industries with the highest numbers and rates of injuries, in most cases, falls were identified as a common cause of injuries. A fractured bone was the most common type of injury, and the extremities were the most common body region affected. It is concluded that the ATR is a reliable tool for work-related injury surveillance and will be helpful in planning research priorities and targeting injury prevention efforts.
KW - accident prevention
KW - accidents
KW - incidence
KW - safety at work
KW - surveillance
KW - trauma
KW - Alaska
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - traumas
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Human Injuries (VV610) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007331&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of Ixodes scapularis and Ixodes ricinus (Acari: Ixodidae) for three genospecies of Borrelia burgdorferi.
AU - Dolan, M. C.
AU - Piesman, J.
AU - Mbow, M. L.
AU - Maupin, G. O.
AU - Péter, O.
AU - Brossard, M.
AU - Golde, W. T.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1998///
VL - 35
IS - 4
SP - 465
EP - 470
SN - 0022-2585
AD - Dolan, M. C.: Division of Vector-Borne Infectious Diseases, National Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990500441. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The vector competence of I. ricinus and I. scapularis was determined and compared for 3 genospecies of B. burgdorferi. The 3 genospecies of B. burgdorferi used in the following experiments were B. burgdorferi s.s. (B-31 and B-31.D1 clone), B. afzelii (strain Pgau.C3) and B. garinii (strain VS286 and VSBP). Spirochaetes from all 5 strains were inoculated intradermally into outbred mice; larval ticks of both species were subsequently fed on those mice and replete larvae were assayed for infection by culture in BSK-H media every 7 days for 4 weeks. Infection frequencies in I. scapularis exposed to the 5 strains were as follows: B-31 (90%), B-31.D1 (83%), Pgau.C3 (87%), VS286 (10%) and VSBP (5%). The comparable infection frequencies for I. ricinus were B-31 (3%), B-31.D1 (3%), Pgau.C3 (90%), VS286 (5%) and VSBP (3%). Resultant nymphal I. scapularis successfully transmitted B-31, B-31.D1, Pgau.C3 and VS286 to outbred mice. I. ricinus nymphs transmitted Pgau.C3 and VS286. Both species failed to transmit strain VSBP.
KW - disease transmission
KW - disease vectors
KW - ectoparasites
KW - epidemiology
KW - infection
KW - laboratory animals
KW - larvae
KW - nymphs
KW - vector competence
KW - Acari
KW - Arachnida
KW - Borrelia
KW - Borrelia afzelii
KW - Borrelia burgdorferi
KW - Borrelia garinii
KW - Ixodes
KW - Ixodes ricinus
KW - Ixodes scapularis
KW - mice
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Borrelia
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500441&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation of La Crosse, Cache Valley, and Potosi viruses from Aedes mosquitoes (Diptera: Culicidae) collected at used-tire sites in Illinois during 1994-1995.
AU - Mitchell, C. J.
AU - Haramis, L. D.
AU - Karabatsos, N.
AU - Smith, G. C.
AU - Starwalt, V. J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1998///
VL - 35
IS - 4
SP - 573
EP - 577
SN - 0022-2585
AD - Mitchell, C. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990500460. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Prospective studies were conducted at used tyre sites in Illinois, USA, during 1994-95 in an effort to isolate arboviruses from mosquitoes, particularly A. albopictus and A. triseriatus. Three isolates of Potosi virus were obtained from A. albopictus collected at a waste tyre site in Jasper County during 1994 and 1995. Also, a single isolate of Cache Valley virus was obtained from A. albopictus collected at the Jasper County site during 1995. These are the first records of arbovirus isolations from A. albopictus In Illinois and the first isolate of Cache Valley virus from this mosquito species. During 1994, 2 isolates of La Crosse virus were made from A. triseriatus collected at a used tyre site in Peoria County in proximity to the residence of a human La Crosse encephalitis case. This is the first evidence in Illinois that indicates increased risk to humans living near used tyre sites, which may serve as foci for production of A. triseriatus, the vector of La Crosse virus. Tyre removal and improved environmental sanitation at such sites may greatly reduce the abundance of vector mosquitoes, and therefore, the risk of arbovirus transmission.
KW - arboviruses
KW - disease vectors
KW - epidemiology
KW - hosts
KW - human diseases
KW - introduced species
KW - new host records
KW - tyres
KW - Illinois
KW - USA
KW - Aedes
KW - Aedes albopictus
KW - Aedes hendersoni
KW - Aedes triseriatus
KW - Cache Valley virus
KW - Culicidae
KW - Diptera
KW - La Crosse virus
KW - man
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Aedes
KW - Bunyamwera virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - California encephalitis virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - Ochlerotatus
KW - Ochlerotatus hendersoni
KW - Ochlerotatus triseriatus
KW - Potosi virus
KW - tires
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500460&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reported distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the United States.
AU - Dennis, D. T.
AU - Nekomoto, T. S.
AU - Victor, J. C.
AU - Paul, W. S.
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 1998///
VL - 35
IS - 5
SP - 629
EP - 638
SN - 0022-2585
AD - Dennis, D. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990500638. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Lyme disease, caused by infection with Borrelia burgdorferi, is the most frequently reported arthropod-borne disease in the USA. To develop a national map of the distribution of the vectors of B. burgdorferi to humans (I. scapularis and I. pacificus ticks), the authors sent questionnaires to acarologists, health officials and Lyme disease researchers; surveyed the 1966-96 MEDLINE database; and reviewed 1907-95 National Tick Collection data. Tick collection methods cited included flagging and dragging, deer surveys, small- and medium-sized mammal surveys, CO2 baiting, and receipt of tick submissions. A total of 1058 unique, county-specific I. scapularis and I. pacificus records was obtained. Tick populations were classified as "reported" (<6 ticks and 1 life stage identified) or "established" (≥6 ticks or >1 life stage identified). Established populations of I. scapularis were identified in 396 counties in 32 states in the eastern and central USA, whereas established populations of I. pacificus were found in 90 counties in 5 western states. Counties with established populations were most concentrated in the northeastern, upper northcentral and west-coastal states but were also clustered in southeastern and Gulf-coastal states. A less concentrated distribution was found in the south-central states. Reports were notably missing from all but a few counties in Ohio, West Virginia, western Virginia and North Carolina, Kentucky and Tennessee. They were absent in the Great Plains and Rocky Mountain regions and from large areas of western states east of the Cascade and Sierra Nevada cordilleras. These data are useful for identifying areas of Lyme disease risk, for targeting Lyme disease prevention strategies, and for monitoring trends in spatial distribution of Lyme disease vector ticks.
KW - disease vectors
KW - ectoparasites
KW - geographical distribution
KW - geographical information systems
KW - maps
KW - questionnaires
KW - surveys
KW - USA
KW - Acari
KW - Arachnida
KW - deer
KW - Ixodes
KW - Ixodes pacificus
KW - Ixodes scapularis
KW - man
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Homo
KW - Hominidae
KW - Primates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - geographic information systems
KW - GIS
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence analysis of the internal transcribed spacer 2 (ITS2) from yeast species within the genus Candida.
AU - Lott, T. J.
AU - Burns, B. M.
AU - Zancope-Oliveira, R.
AU - Elie, C. M.
AU - Reiss, E.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 1998///
VL - 36
IS - 2
SP - 63
EP - 69
SN - 0343-8651
AD - Lott, T. J.: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention and Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19981201118. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Nucleotide sequences of the internal transcribed spacer 2 (ITS2) regions were determined for 13 species within the genus Candida (including C. albicans, C. parapsilosis, C. tropicalis, C. glabrata [Torulopsis glabrata], C. guilliermondii, C. famata [T. candida], C. kefyr and C. lusitaniae). No 2 species had identical sequences and the sizes of ITS2 varied 4-fold, representing an apparent continuous gradient of nucleotides. When present, sequence homologies were observed in the 5′ end of ITS2, and many species showed more limited homologies within 3 known conserved domains found in other yeasts. Cluster analysis of primary sequence revealed a concordance with a known taxonomic subfamily and suggested that certain species within the genus form a similar grouping. A majority of species showed similar presumptive RNA secondary structures, consistent with the hypothesis that these spacer regions are essential for correct processing of the 5.8S and 28S subunits.
KW - analysis
KW - genetics
KW - nucleotide sequences
KW - species
KW - taxonomy
KW - Blastodendrion arztii
KW - Candida
KW - Candida albicans
KW - Candida glabrata
KW - Candida kefyr
KW - Candida lusitaniae
KW - Candida parapsilosis
KW - Candida saitoana
KW - Candida tropicalis
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Candida
KW - Torulopsis
KW - Pezizomycotina
KW - Blastodendrion
KW - Candida guilliermondii
KW - DNA sequences
KW - fungus
KW - Hyphomycetes
KW - systematics
KW - Torulopsis candida
KW - Torulopsis glabrata
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981201118&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CDC group O-3: phenotypic characteristics, fatty acid composition, isoprenoid quinone content, and in vitro antimicrobic susceptibilities of an unusual Gram-negative bacterium isolated from clinical specimens.
AU - Daneshvar, M. I.
AU - Hill, B.
AU - Hollis, D. G.
AU - Moss, C. W.
AU - Jordan, J. G.
AU - MacGregor, J. P.
AU - Tenover, F.
AU - Weyant, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1998///
VL - 36
IS - 6
SP - 1674
EP - 1678
SN - 0095-1137
AD - Daneshvar, M. I.: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19982013093. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 56-75-7, 85721-33-1, 64221-86-9, 57-50-1, 58-86-6.
N2 - Between 1983 and 1994, 13 phenotypically similar unidentified clinical isolates were received by the Special Bacteriology Reference Laboratory, Centers for Disease Control and Prevention (CDC), USA. Sources included blood (4 strains), lung (3 strains), knee fluid and duodenal tissue (one strain each), bone, and lymph node tissue (2 strains each). All were aerobic glucose-oxidizing, slender, long, curved Gram-negative rods that utilized xylose, sucrose, and maltose; did not grow on MacConkey agar in 1 to 2 days; were oxidase positive; hydrolysed esculin; and grew on Campylobacter selective medium. All were negative for urease, indole, nitrate reduction, and gelatin hydrolysis. All were motile by means of a single polar flagellum with a noticeably short wavelength; however, motility was sometimes difficult to demonstrate. The cellular fatty acid compositions of these strains, as analysed by gas-liquid chromatography, were unique, characterized by relatively large amounts of 16:1ω7c, 16:0, and 18:1ω7c with smaller amounts of 12:0, 3-OH-12:1, 14:0, 15:0, 18:0, Br-19:1, and 19:0cyc11-12. High-performance liquid chromatography and mass spectrometry of the quinone extracts of 3 representative strains showed ubiquinone-10 as the major component. Based on the breakpoints for the family Enterobacteriaceae, all the strains were susceptible in vitro to aminoglycosides, sulfamethoxazole-trimethoprim, and chloramphenicol but were resistant to most beta-lactams except imipenem. The MICs of amoxicillin-clavulanate and ciprofloxacin for these strains clustered around the breakpoints, which makes it difficult to predict the strains' response in vivo to these agents. This group has been designated CDC oxidizer group 3 (O-3).
KW - antibiotics
KW - characteristics
KW - chloramphenicol
KW - chromatography
KW - ciprofloxacin
KW - composition
KW - drug resistance
KW - fatty acids
KW - gas liquid chromatography
KW - Gram negative bacteria
KW - imipenem
KW - in vitro
KW - laboratories
KW - lungs
KW - lymph nodes
KW - phenotypes
KW - specimens
KW - strains
KW - sucrose
KW - susceptibility
KW - xylose
KW - USA
KW - Bacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - CDC group O-3
KW - Gram-negative bacteria
KW - phenotypic characteristics
KW - saccharose
KW - United States of America
KW - wood sugar
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sudden increase in isolation of group B streptococci, serotype V, is not due to emergence of a new pulsed-field gel electrophoresis type.
AU - Elliott, J. A.
AU - Farmer, K. D.
AU - Facklam, R. R.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1998///
VL - 36
IS - 7
SP - 2115
EP - 2116
SN - 0095-1137
AD - Elliott, J. A.: Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982013489. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - Until recently, group B streptococcus serotype V (GBS-V), was an infrequent cause of disease. It is now recognized as a significant cause of infections in both children and adults. To determine if this increase was due to the recent introduction and spread of a single clone of GBS-V, an analysis was made, by pulsed-field gel electrophoresis (PFGE), of the SmaI chromosomal DNA digests of 45 bacteria: 41 isolated from human infections between 1986 and 1996 in the USA, 2 from human infections in Argentina, and 2 from naturally infected mice. 17 patterns were found and arbitrarily designated patterns A-Q. Pattern N constituted 24 (53%) of the isolates and was found in all of the years tested and from all surveillance areas, as well as in both isolates from Argentina, and was very similar to the GBS-V isolated from a mouse. Pattern P was found in 3 isolates, pattern F was found in 2, and the remaining patterns were found in one isolate each. It is concluded that the majority of isolates of GBS-V are of one PFGE subtype and that this subtype was predominant before the increase in disease caused by GBS-V, and that GBS-V disease is caused by several different subtypes.
KW - bacterial diseases
KW - characterization
KW - DNA fingerprinting
KW - epidemiology
KW - group B streptococci
KW - human diseases
KW - identification
KW - serotypes
KW - Argentina
KW - USA
KW - man
KW - mice
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Human T-lymphotropic virus types I and II in Africa in 1969.
AU - Tabor, E.
T2 - Transfusion
JO - Transfusion
JF - Transfusion
Y1 - 1998///
VL - 38
IS - 6
SP - 612
EP - 613
SN - 0041-1132
AD - Tabor, E.: Division of Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.
N1 - Accession Number: 19982010908. Publication Type: Correspondence. Language: English. Number of References: 5 ref.
KW - epidemiology
KW - human diseases
KW - Africa
KW - Deltaretrovirus
KW - human T-cell lymphotropic virus type I
KW - human T-cell lymphotropic virus type II
KW - man
KW - Human T-cell lymphotropic virus
KW - Deltaretrovirus
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - HTLV-BLV group
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982010908&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Studies to address reports of human T-lymphotropic virus type I tax sequences in US blood donors.
AU - Cowan, E. P.
AU - Tabor, E.
AU - Nemo, G.
AU - Williams, A.
AU - Lal, R. B.
AU - Busch, M. P.
T2 - Transfusion
JO - Transfusion
JF - Transfusion
Y1 - 1998///
VL - 38
IS - 8
SP - 800
EP - 801
SN - 0041-1132
AD - Cowan, E. P.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19982011972. Publication Type: Correspondence. Language: English. Number of References: 6 ref.
N2 - The correspondents respond to a letter by Zucker-Franklin and Pancake (Transfusion (1998) 38 317), which reported the detection of HTLV-I tax gene sequences in the blood of individuals who were seronegative for anti-HTLV-I.
KW - blood
KW - blood donors
KW - blood transfusion
KW - nucleotide sequences
KW - TAX gene
KW - Deltaretrovirus
KW - human T-cell lymphotropic virus type I
KW - Human T-cell lymphotropic virus
KW - Deltaretrovirus
KW - viruses
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - DNA sequences
KW - HTLV-BLV group
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011972&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health claims for infant formulas and foods: U.S. regulations.
AU - Yetley, E. A.
A2 - Perman, J. A.
A2 - Rey, J.
JO - Nestlé Nutrition Workshop Series
JF - Nestlé Nutrition Workshop Series
Y1 - 1998///
VL - 40
SP - 219
EP - 229
SN - 0742-2806
AD - Yetley, E. A.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19981414938. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Subject Subsets: Human Nutrition
N2 - Regulation of infant food label claims in the USA is discussed.
KW - food legislation
KW - health foods
KW - infant foods
KW - infants
KW - labelling
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - labeling
KW - labels
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Laws and Regulations (DD500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and analysis of staphylococcal enterotoxin A in food by Western immunoblotting.
AU - Rasooly, A.
AU - Rasooly, R. S.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 1998///
VL - 41
IS - 3
SP - 205
EP - 212
SN - 0168-1605
AD - Rasooly, A.: U.S. Food and Drug Administration, Division of Microbiological Studies, Washington, DC 20204, USA.
N1 - Accession Number: 19990401274. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition; Horticultural Science; Dairy Science
N2 - A simple Western immunoblotting protocol was developed to identify and measure the level of Staphylococcus aureus enterotoxin A (SEA) in food. Test samples were homogenized with no additional solubilization or pre-treatment steps. The immunoblots detected SEA at levels ≥100 pg/ml. Using simplified sample preparation, native and heat-denatured SEA were identified in a variety of foods including mushrooms, milk, potato salad and meat products. Data suggested that SEA is being secreted at mid-log growth in BHI media as well as in mushrooms. Results suggested that Western blotting was a useful tool for determining the presence of SEA in foods because it allowed characterization of the antigen reacting with the antibody and could be used for heat-treated foods, thus overcoming some of the limitations of the ELISA test.
KW - analytical methods
KW - edible fungi
KW - enterotoxins
KW - foods
KW - meat products
KW - microbial contamination
KW - milk
KW - mushrooms
KW - fungi
KW - Staphylococcus aureus
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990401274&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The use of amino acid sequence alignments to assess potential allergenicity of proteins used in genetically modified foods.
AU - Gendel, S. M.
JO - Advances in Food and Nutrition Research
JF - Advances in Food and Nutrition Research
Y1 - 1998///
VL - 42
SP - 45
EP - 62
AD - Gendel, S. M.: Biotechnology Studies Branch, Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 19981412987. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition
N2 - To determine the best method for utilising sequence information in assessing the potential allergenicity of proteins used in new food varieties, the author compared the results obtained by using different sequence alignment strategies with several test sequences and 2 allergen sequence databases. The test sequence included synthetic control sequences and sequences for proteins that are currently being used in transgenic foods. Local alignment algorithms which optimize alignments only within regions of high similarity were more appropriate for use in this context than global alignment algorithms which optimize alignments across the entire length of the sequences involved. The proper scoring matrix had to be used to reliably locate significant matches. The lack of reliable criteria for defining an allergenic epitope made it difficult to assess the biological significance of the matches that were defined.
KW - allergens
KW - amino acid sequences
KW - analytical methods
KW - biotechnology
KW - databases
KW - food allergies
KW - foods
KW - genetic engineering
KW - proteins
KW - analytical techniques
KW - data banks
KW - food hypersensitivity
KW - genetic manipulation
KW - protein sequences
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412987&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence databases for assessing the potential allergenicity of proteins used in transgenic foods.
AU - Gendel, S. M.
JO - Advances in Food and Nutrition Research
JF - Advances in Food and Nutrition Research
Y1 - 1998///
VL - 42
SP - 63
EP - 92
AD - Gendel, S. M.: Biotechnology Studies Branch, Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 19981412988. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - Two databases of allergen sequences (food allergens and non-food allergens) were constructed using information from 3 large reference protein sequence databases (GenPept, release 94; Protein Identification Resource, release 48; and SwissProt, release 33) for assessing the potential allergenicity of proteins introduced into transgenic foods. Allergen sequences were identified in each of the reference databases and compared to homologous sequences in each reference database to identify equivalent sequences and allelic variants. This information was used to construct non-redundant allergen sequence databases that contain all currently available sequence variants for food and non-food allergens. A third database of wheat gluten protein sequences was also constructed. These databases will be updated periodically as new allergen sequences become available and as new proteins are identified as allergens and the updated database will be made available on-line (http://www.iit.edu/~sgendel).
KW - allergens
KW - amino acid sequences
KW - databases
KW - food allergies
KW - foods
KW - genetic engineering
KW - proteins
KW - data banks
KW - food hypersensitivity
KW - genetic manipulation
KW - protein sequences
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Food Composition and Quality (QQ500)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Information and Documentation (CC300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412988&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - First isolation of enteric adenoviruses type 41 from children with acute gastroenteritis in Hungary.
AU - Szucs, G.
AU - Új, M.
JO - Acta Microbiologica et Immunologica Hungarica
JF - Acta Microbiologica et Immunologica Hungarica
Y1 - 1998///
VL - 45
IS - 3/4
SP - 425
EP - 431
SN - 1217-8950
AD - Szucs, G.: Regional Laboratory of Virology, Baranya County Institute of the State Public Health Service P.O. Box 47, H-7601, Pécs, Hungary.
N1 - Accession Number: 19992005826. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9007-49-2.
N2 - In a retrospective study, 122 stool specimens collected during 1989-90 from children with gastroenteritis were found to contain adenoviruses. 29 adenoviruses of 50 randomly selected adenovirus-positive faecal samples were successfully propagated in Graham 293 cells and were typed by DNA restriction enzyme analysis with SmaI. Six strains were typed as adenovirus 41 (Ad41), and 23 strains as non-enteric adenovirus. All 6 adenoviruses type 41 had the same DNA pattern identical with that of the variant Ad41/D12. Ad40 viruses were not detected. Enteric Ad41 infections were observed only in males and were found throughout the year. To the authors' knowledge this is the first report on isolation and typing of enteric adenovirus 41 in Hungary.
KW - children
KW - DNA
KW - epidemiology
KW - gastroenteritis
KW - human diseases
KW - males
KW - strains
KW - Hungary
KW - human adenovirus 41
KW - man
KW - human adenovirus
KW - Mastadenovirus
KW - Adenoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - deoxyribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992005826&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of chlorothiazide and hydrochlorothiazide diuretic drugs in bovine milk.
AU - Shaikh, B.
AU - Rummel, N.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1998///
VL - 46
IS - 3
SP - 1039
EP - 1043
SN - 0021-8561
AD - Shaikh, B.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
N1 - Accession Number: 19980403111. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 58-94-6, 58-93-5. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science
N2 - Whole milk was defatted by centrifugation at 4°C. The top layer was treated with lead acetate and acetonitrile, mixed, and centrifuged. The supernatant was extracted with ethyl acetate to remove acetonitrile. The solvent mixture was then treated with sodium tungstate and mixed. The top layer was removed and evaporated to dryness, the residue was dissolved in the mobile phase, and the final extract was analysed by liquid chromatography (LC). The LC employed a polymer column, a mobile phase of acetonitrile/tetrahydrofuran in phosphate buffer, and an ultraviolet detector. The average recoveries of chlorothiazide (CTZ) from milk fortified at 35, 70 and 140 ppb were 97, 96 and 99%, respectively, with corresponding coefficients of variation (CV) of 8, 5 and 5%. The average recoveries of hydrochlorothiazide (HCTZ) at 35, 70 and 140 ppb were 87, 91 and 90%, respectively, with CV of 5, 6 and 5%. The method was validated by assaying milk obtained from cows dosed separately with the 2 diuretics. CTZ was detected in 8-h (430 ppb) and 24-h (85 ppb) incurred milk samples and HCTZ (47 ppb) only in the 8-h incurred milk samples.
KW - analytical methods
KW - chlorothiazide
KW - contamination
KW - cows
KW - diuretics
KW - drug therapy
KW - drugs
KW - hydrochlorothiazide
KW - liquid chromatography
KW - milk
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - chemotherapy
KW - medicines
KW - pharmaceuticals
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980403111&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Formation of N-(carboxymethyl)fumonisin B1, following the reaction of fumonisin B1 with reducing sugars.
AU - Howard, P. C.
AU - Churchwell, M. I.
AU - Couch, L. H.
AU - Marques, M. M.
AU - Doerge, D. R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1998///
VL - 46
IS - 9
SP - 3546
EP - 3557
SN - 0021-8561
AD - Howard, P. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19981203116. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology; Maize; Postharvest Research
N2 - The incubation of fumonisin B1 with D-glucose resulted in the formation of N-(carboxymethyl)fumonisin B1, which was characterized by NMR and electrospray mass spectroscopy. The methylene carbon of the carboxymethyl group is derived from C1 on glucose, while the carbonyl carbon is derived from the C2 of glucose, using [13C]glucose. Apparently N-(carboxymethyl)fumonisin B1 arises from Schiff's base formation, Amadori rearrangement to a β-ketoamine and oxidation with molecular oxygen. N-(Carboxymethyl)fumonisin B1 formation is favoured by alkaline conditions (pH >7), requires molecular oxygen and is catalysed by several reducing sugars. N-(Carboxymethyl)fumonisin B1 was detected in raw corn [maize] samples that contained fumonisin B1 (0.5-1.4 p.p.m.) at a mean of 4% of the fumonisin B1 levels.
KW - contamination
KW - derivatives
KW - fumonisins
KW - maize
KW - mycotoxins
KW - reducing sugars
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - fungal toxins
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981203116&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recommendations for prevention and control of tuberculosis among foreign-born persons.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1998///
VL - 47
IS - RR-16
SP - ii + 29
EP - ii + 29
SN - 0149-2195
AD - US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19992000394. Publication Type: Journal Article. Corporate Author: USA, Working Group on Tuberculosis Among Foreign-Born Persons Language: English.
KW - bacterial diseases
KW - diagnosis
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - immigrants
KW - mycobacterial diseases
KW - screening
KW - tuberculosis
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - mycobacterial infections
KW - screening tests
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000394&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1998///
VL - 47
IS - rr-19
SP - v + 39
EP - v + 39
SN - 0149-2195
AD - US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19992000374. Publication Type: Miscellaneous. Language: English. Number of References: 158 ref.
KW - behaviour
KW - chemoprophylaxis
KW - clinical aspects
KW - diagnosis
KW - disease control
KW - disease prevention
KW - drug therapy
KW - epidemiology
KW - guidelines
KW - hepatitis
KW - hepatitis C
KW - human diseases
KW - liver diseases
KW - risk behaviour
KW - risk factors
KW - screening
KW - surveillance
KW - viral diseases
KW - viral hepatitis
KW - USA
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - chemotherapy
KW - clinical picture
KW - recommendations
KW - risk behavior
KW - screening tests
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992000374&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative safety of two recombinant hepatitis B vaccines in children: data from the Vaccine Adverse Event Reporting System (VAERS) and Vaccine Safety Datalink (VSD).
AU - Niu, M. T.
AU - Rhodes, P.
AU - Salive, M.
AU - Lively, T.
AU - Davis, D. M.
AU - Black, S.
AU - Shinefield, H.
AU - Chen, R. T.
AU - Ellenberg, S. S.
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 1998///
VL - 51
IS - 6
SP - 503
EP - 510
SN - 0895-4356
AD - Niu, M. T.: Division of Biostatistics and Epidemiology, Office of Establishment Licensing and Product Surveillance, Center for Biologic Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19982009819. Publication Type: Journal Article. Corporate Author: USA, Vaccine Adverse Event Reporting System Working Group; USA, Vaccine Safety Datalink Working Group Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - To compare the post-marketing safety experience of the 2 recombinant hepatitis B (HepB) vaccines licensed for use in infants and children in the USA, a review of a case series derived from passive surveillance data in the national VAERS, and a retrospective cohort study using data from one health maintenance organization participating in VSD, were carried out for the period 1991-94. The study population comprised US children, ages birth-10 years for whom adverse events after HepB vaccine were reported to VAERS during 1991-94, and children, ages birth-6 years, who received HepB vaccine at Kaiser Permanente Medical Care Program, Northern California, during the same period. In VAERS, higher rates of serious events (i.e., life threatening or resulting in hospitalization or permanent disability) were reported in children who received Vaccine A vs. Vaccine B (relative risk (RR): 3.13-8.18, P<0.01), particularly by those vaccinated in the private (RR: 7.62-28.58, P<0.01), but not public sector (RR: 2.12, P=0.19). Similar types of events were reported in recipients of both vaccines. In contrast, analysis of VSD data showed no significant difference in rates of hospitalization or emergency room visits in children who received either HepB vaccine (RR: 0.96-1.25, P>0.05). It is concluded that it is unlikely there is a true difference between rates of serious events temporally associated with the 2 HepB vaccines in children.
KW - adverse effects
KW - children
KW - epidemiology
KW - hepatitis
KW - hepatitis B
KW - human diseases
KW - immunization
KW - infants
KW - liver diseases
KW - recombinant vaccines
KW - safety
KW - surveillance
KW - vaccination
KW - vaccines
KW - viral diseases
KW - viral hepatitis
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009819&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New World hantaviruses.
AU - Young, J. C.
AU - Mills, J. N.
AU - Enria, D. A.
AU - Dolan, N. E.
AU - Khan, A. S.
AU - Ksiazek, T. G.
A2 - Spratt, B. G.
JO - British Medical Bulletin
JF - British Medical Bulletin
Y1 - 1998///
VL - 54
IS - 3
SP - 659
EP - 673
SN - 0007-1420
AD - Young, J. C.: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30329-4018, USA.
N1 - Accession Number: 19990505707. Publication Type: Journal Article. Language: English. Number of References: 43 ref.
N2 - Since the initial description in 1993 of hantavirus pulmonary syndrome and its novel aetiological agent, Sin Nombre virus, knowledge of the epidemiology of New World hantaviruses has continued to evolve. After the identifying outbreak in the southwestern USA, 4 hantaviruses have been identified in North America with specific rodent hosts and associated with a number of sporadic cases. This stability of case recognition in North America is in contrast to the multiple outbreaks and endemic cases in South America. Despite a plethora of New World hantaviruses and new evidence of person-to-person transmission, the ecological and personal determinants of this human infection remain a mystery.
KW - aetiology
KW - disease transmission
KW - epidemiology
KW - hantavirus pulmonary syndrome
KW - hosts
KW - human diseases
KW - lungs
KW - outbreaks
KW - zoonoses
KW - America
KW - North America
KW - South America
KW - Hantavirus
KW - man
KW - rodents
KW - Sin Nombre virus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hantavirus
KW - America
KW - causal agents
KW - etiology
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505707&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sampling and analytical method development for qualitative assessment of airborne mycobacterial species of the Mycobacterium tuberculosis complex.
AU - Schafer, M. P.
AU - Fernback, J. E.
AU - Jensen, P. A.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1998///
VL - 59
IS - 8
SP - 540
EP - 546
SN - 0002-8894
AD - Schafer, M. P.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-7, Cincinnati, OH 45226-1099, USA.
N1 - Accession Number: 19982013167. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - A novel, qualitative approach for detecting airborne M. tuberculosis is described. A DNA diagnostic method involving the polymerase chain reaction (PCR) coupled to an enzymatically generated colour reaction was used for direct detection of M. bovis BCG (bacille Calmette-Guérin), a surrogate for pathogenic M. tuberculosis. Fewer than 10 mycobacteria were detected using this bioanalytical method. Analysis was completed in 1-1.5 days, in contrast to traditional culturing methods requiring a minimum of 2-3 weeks. To evaluate an air sampling method coupled to a PCR bioanalytical method, liquid cultures of the surrogate were aerosolized and collected for PCR analyses using 37-mm filter cassettes containing polytetrafluoroethylene filters. An Andersen 6-stage (viable) particle sizing sampler was employed as a reference sampler. Aerosolized BCG impacted onto Andersen agar plates required incubation periods of 6-8 weeks before small colony forming units could be detected and enumerated. Although the mean length of the BCG rod-shaped particles was 8.3 µm, the airborne BCG particles were collected predominantly on the Andersen 4-6 stages, representing aerodynamic diameters 0.7-3.3 µm. Approximately 25 mycobacteria were detected without culturing using the PCR-filter cassette method. This approach could be used to detect airborne mycobacterial species of the M. tuberculosis complex and could permit the early detection of contaminated indoor air. Also, the efficacy of environmental controls could be evaluated and monitored. This approach could also be used to study the expulsion of infectious particles from patients and may permit risk assessment in regard to personal respiratory protection.
KW - aerosols
KW - air
KW - analytical methods
KW - contamination
KW - detection
KW - methodology
KW - polymerase chain reaction
KW - sampling
KW - Mycobacterium
KW - Mycobacterium tuberculosis
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - analytical techniques
KW - bacterium
KW - methods
KW - PCR
KW - sampling techniques
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013167&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viral excretion in domestic ferrets (Mustela putorius furo) inoculated with a raccoon rabies isolate.
AU - Niezgoda, M.
AU - Briggs, D. J.
AU - Shaddock, J.
AU - Rupprecht, C. E.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 1998///
VL - 59
IS - 12
SP - 1629
EP - 1632
SN - 0002-9645
AD - Niezgoda, M.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, 1600 Clifton Rd NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 19992203613. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Five groups of ferrets were inoculated i.m. with rabies virus. Oral cavity swab specimens and saliva were obtained for virus isolation. Blood was obtained for virus-neutralizing antibody determination. If clinical signs were severe, ferrets were killed immediately. Salivary gland and brain tissue was collected for virus isolation and rabies diagnosis, respectively. Of 51 inoculated ferrets, 19 (37%) were killed with clinical signs of rabies. Mean incubation period was 28 days (range, 17 to 63 days). Clinical signs included ataxia, cachexia, inactivity, paresis, paraparesis, bladder atony, tremors, hypothermia, lethargy, constipation, paralysis and anorexia. Two rabid ferrets manifested aggressive behaviour. Mean morbidity period was 4 to 5 days (range, 1 to 8 days). Virus antigen was detected in brain tissue from all of 19 rabid ferrets. Two rabid ferrets had detectable virus-neutralizing antibody. Of 32 ferrets that survived, only 1 seroconverted. Survivors remained healthy throughout the observation period. Rabies virus was isolated from salivary glands of 12 of 19 (63%) rabid ferrets, and 9 (47%) shed virus in saliva. Initiation of virus excretion ranged from 2 days before onset of illness to 6 days after onset. It is concluded that rabies should be considered in the differential diagnosis for ferrets that have acute onset of paralysis or behavioral changes and a condition that rapidly deteriorates despite intense medical intervention.
KW - antigens
KW - diagnosis
KW - experimental infections
KW - prepatent period
KW - rabies
KW - salivary glands
KW - symptoms
KW - viral diseases
KW - ferrets
KW - rabies virus
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - immunogens
KW - incubation period
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pets and Companion Animals (LL070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992203613&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The incidence of Listeria spp., Salmonella spp., and Clostridium botulinum in smoked fish and shellfish.
AU - Heinitz, M. L.
AU - Johnson, J. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1998///
VL - 61
IS - 3
SP - 318
EP - 323
SN - 0362-028X
AD - Heinitz, M. L.: U.S. Food and Drug Administration, 240 Hennepin Ave., Minneapolis, Minnesota, 55401-1999, USA.
N1 - Accession Number: 19981412411. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Human Nutrition
N2 - 1080 samples were analysed between 1991 and 1995 in the USA. L. monocytogenes was isolated from 14% of samples. For those samples where the smoke process was known, the incidence of L. monocytogenes was higher in cold-smoked than hot-smoked products (51 of 240 cold-smoked compared to 19 of 215 hot-smoked products). Listeria species other than L. monocytogenes were also detected (in 7.2% of cold-smoked and 3.8% of hot-smoked products). The time and temperature smoke processing guidelines are reviewed for a few state authorities. L. monocytogenes was isolated from 15.2% of the 559 samples of foreign origin. There were 4 countries for which more than 70 samples were analysed: Canada, Norway, the Philippines and UK. The occurrence of L. monocytogenes in samples from these 4 countries was 14.3, 23.7, 0 and 16.1%, respectively. The 521 samples originating in the USA were processed by 194 plants. 37 plants in 13 states produced contaminated product. Salmonella species were isolated from 5 (3.2%) of 156 samples tested for this organism. All positive samples were of foreign origin (4 from the Philippines and 1 from the UK). No C. botulinum spores were detected in any of the 201 vacuum-packed samples tested for this organism.
KW - fish
KW - food contamination
KW - microbial contamination
KW - shellfish
KW - smoked fish
KW - Canada
KW - Norway
KW - Philippines
KW - UK
KW - USA
KW - Clostridium botulinum
KW - Listeria
KW - Listeria monocytogenes
KW - Salmonella
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Listeria
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - EFTA
KW - Scandinavia
KW - Northern Europe
KW - Europe
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - British Isles
KW - Western Europe
KW - European Union Countries
KW - bacterium
KW - Britain
KW - food contaminants
KW - United Kingdom
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981412411&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Listeria monocytogenes from unpasteurized apple juice using rapid test kits.
AU - Sado, P. N.
AU - Jinneman, K. C.
AU - Husby, G. J.
AU - Sorg, S. M.
AU - Omiecinski, C. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1998///
VL - 61
IS - 9
SP - 1199
EP - 1202
SN - 0362-028X
AD - Sado, P. N.: US Food and Drug Administration, Bothell, Washington 98041, USA.
N1 - Accession Number: 19981417045. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - A microbiological survey of 50 retail juices was conducted in the autumn of 1996. These juices were analysed for L. monocytogenes, Escherichia coli O157:H7, Salmonella, coliforms, faecal coliforms, and pH. Two unpasteurized juices were positive for L. monocytogenes: an apple juice and an apple raspberry blend with a pH of 3.78 and 3.75, respectively. Three L. monocytogenes isolates were characterized. The colonies were typical for Listeria sp. on Oxford and lithium chloride-phenylethanol-moxalactam agars and were β-haemolytic on sheep blood agar. The isolates required 5 days of incubation at 35°C to produce a positive rhamnose reaction in a phenol red carbohydrate broth. This slow rhamnose utilization resulted in these isolates not being identified using the Micro-ID test strip (Organon Technika). However, the isolates were positive for L. monocytogenes using the API Listeria strip (BioMerieux) and a multiplex polymerase chain reaction for detection of the haemolysis (hyla) and invasion-associated protein (iap) genes.
KW - apple juice
KW - faecal coliforms
KW - fruit juices
KW - identification
KW - microbial contamination
KW - pH
KW - raspberries
KW - USA
KW - Washington
KW - Escherichia coli
KW - Listeria monocytogenes
KW - Rubus
KW - Salmonella
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - hydrogen ion concentration
KW - potential of hydrogen
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981417045&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cheese-associated outbreaks of human illness in the United States, 1973 to 1992: sanitary manufacturing practices protect consumers.
AU - Altekruse, S. F.
AU - Timbo, B. B.
AU - Mowbray, J. C.
AU - Bean, N. H.
AU - Potter, M. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1998///
VL - 61
IS - 10
SP - 1405
EP - 1407
SN - 0362-028X
AD - Altekruse, S. F.: Foodborne and Diarrheal Diseases Branch (A-38), National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19990400777. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - To identify contributing factors for cheese-associated outbreaks, all cheese-associated outbreaks of human illness reported to the US Centers for Disease Control and Prevention (CDC) with onsets during 1973 to 1992 were reviewed. The infrequency of large, cheese-associated outbreaks was notable because such outbreaks had been a frequent public health problem before the mid-20th century. Of 32 reported cheese-associated outbreaks, 11 attributed to manufacturing errors caused most of the illnesses and hospitalizations and all 58 deaths. Important factors in these 11 outbreaks were manufacturing cheese with raw or improperly pasteurized milk and post-pasteurization contamination. If current Food and Drug Administration sanitary requirements for cheesemaking had been met, these outbreaks would have been preventable. In 2 outbreaks of Salmonella infections, <10 Salmonella/100 g cheese were detected. In 2 outbreaks of Brucella infections, efforts to recover the pathogen from the implicated cheese were unsuccessful, emphasizing the inadequacy of end product testing for assuring consumer safety. Ripening cheeses kills most bacteria present in cheeses; however, evidence from sources other than the CDC Foodborne Disease Outbreak Surveillance System suggests that ripening alone may not be a sufficient pathogen control step to eliminate Salmonella, Listeria and E. coli O157:H7 from cheese.
KW - cheeses
KW - food poisoning
KW - microbial contamination
KW - milk hygiene
KW - milk processing
KW - pathogens
KW - reviews
KW - USA
KW - Brucella
KW - Escherichia coli
KW - Listeria
KW - man
KW - Salmonella
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990400777&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Template preparation for PCR and RFLP of amplification products for the detection and identification of Cyclospora sp. and Eimeria spp. oocysts directly from raspberries.
AU - Jinneman, K. C.
AU - Wetherington, J. H.
AU - Hill, W. E.
AU - Adams, A. M.
AU - Johnson, J. M.
AU - Tenge, B. J.
AU - Dang, N. L.
AU - Manger, R. L.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1998///
VL - 61
IS - 11
SP - 1497
EP - 1503
SN - 0362-028X
AD - Jinneman, K. C.: Seafood Products Research Center, Seattle District, U.S. Food and Drug Administration, 22201 23rd Dr. S. E., P.O. Box 3012, Bothell, WA 98041, USA.
N1 - Accession Number: 19990801598. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Protozoology
N2 - Raspberries were epidemiologically associated with cyclosporiasis outbreaks in the USA during 1996 and 1997. To help identify the protozoa in food and environmental samples, a restriction fragment length polymorphism (RFLP) analysis of amplified products was used to differentiate Cyclospora cayetanensis from Eimeria spp. Polymerase chain reaction (PCR) inhibitors and the low levels of Cyclospora oocysts present in raspberries presented a challenge for template preparation for PCR and several approaches were evaluated. Template preparation methods using various washing and concentration steps, oocyst disruption protocols, resin matrix treatment, DNA precipitation and/or the addition of nonfat dried milk solution to a PCR using modified primers were evaluated first with oocysts of E. tenella then refined with oocysts of C. cayetanensis. Approximately 10 E. tenella oocysts or ~ 19 C. cayetanensis oocysts per PCR were detected with the optimized template preparation method. The addition of 20 µl of raspberry wash sediment extract and nonfat dried milk solution did not inhibit the amplification of DNA from as few as 10 E. tenella and 25 C. cayetanensis oocysts in a 100-µl PCR. The nucleotide sequences of C. cayetanensis and Eimeria spp. are 94 to 96% similar in the amplified region and the amplification products from the 2 genera were distinguished using an RFLP analysis with the restriction enzyme MnlI.
KW - biotechnology
KW - detection
KW - disease transmission
KW - DNA amplification
KW - epidemiology
KW - foodborne diseases
KW - nucleotide sequences
KW - oocysts
KW - outbreaks
KW - parasites
KW - polymerase chain reaction
KW - protozoal infections
KW - raspberries
KW - restriction endonuclease analysis
KW - restriction endonucleases
KW - restriction fragment length polymorphism
KW - techniques
KW - USA
KW - Cyclospora cayetanensis
KW - Eimeria
KW - protozoa
KW - Rubus
KW - Cyclospora
KW - Eimeriidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - DNA sequences
KW - PCR
KW - protozoal diseases
KW - RFLP
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of a microbiological assay with tri-enzyme extraction for measurement of pre-fortification levels of folates in enriched cereal-grain products.
AU - Rader, J. I.
AU - Weaver, C. M.
AU - Angyal, G.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1998///
VL - 62
IS - 4
SP - 451
EP - 465
SN - 0308-8146
AD - Rader, J. I.: Office of Food Labeling, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19981415228. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts; Maize
N2 - Folate was measured in 56 folate-enriched foods produced in the USA in 1998, including enriched breads and rolls, flours, corn [maize] grits and meals, rices and macaroni and noodle products. Folate was measured by a modification of the Association of Official Analytical Chemists' microbiological method 992.05 using Lactobacillus casei. Foods were composited, suspended in 0.1 M phosphate buffer containing 1% ascorbic acid (pH 7.8), autoclaved and cooled. Chicken pancreas conjugase was added and the suspensions were incubated for 16 h at 37°C. Values for folate in enriched products were (µg/100 g): bread and rolls 24-40; flours 19-24; corn grits and meals 22-32; macaroni and noodle products 27-42; and rice 19-32. Because the single-enzyme method is usually insufficient to liberate food-bound folates, suspensions of foods were also incubated with α-amylase and conjugase followed by treatment with protease to determine the effects of the tri-enzyme digestion on release of folates. For many foods, total folate was 20-30% higher after the tri-enzyme digestion than after incubation with conjugase alone. It is concluded that the modifications of AOAC method 992.05 described here provide a microbiological assay method for the determination of folates in cereal-grain products that may be appropriate for collaborative testing.
KW - analytical methods
KW - cereal products
KW - composition
KW - enzymes
KW - folic acid
KW - foods
KW - fortification
KW - vitamins
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - folacin
KW - folate
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981415228&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bedside percutaneous tracheostomy in acquired immunodeficiency syndrome.
AU - Flum, D. R.
AU - Steinberg, S. D.
AU - Adams, P. X.
AU - Wallack, M. K.
JO - American Surgeon
JF - American Surgeon
Y1 - 1998///
VL - 64
IS - 5
SP - 444
EP - 446
SN - 0003-1348
AD - Flum, D. R.: Indian Health Service, Drawer PH, Chinle Hospital, Chinle, AZ 86503-9998, USA.
N1 - Accession Number: 19982007236. Publication Type: Journal Article. Language: English. Number of References: 12 ref.
N2 - Nine consecutive patients diagnosed with AIDS and undergoing percutaneous tracheostomy from January 1, 1992 to December 31, 1996, were identified. All patients were males (mean age 32.1 ± 4 years, CD4+ cell count average 145) and were ventilator-dependent for a mean of 24 ± 3 days. The procedure was successful and without complications in all patients. Follow-up was 27 months (range, 1-42 months) and in-hospital stay was 29 days (range, 3-120). Two patients survived the hospitalization after undergoing decannulation on postoperative days 29 and 52, respectively. Despite the poor prognosis after tracheostomy in patients with AIDS, this procedure allows better oral care and may improve patient comfort. Bedside percutaneous tracheostomy can be performed with less risk to surgical personnel and patient when compared to conventional surgery. This minimally invasive procedure safely and efficiently provides prolonged tracheal access in patients with AIDS.
KW - acquired immune deficiency syndrome
KW - CD4+ lymphocytes
KW - complications
KW - human diseases
KW - human immunodeficiency viruses
KW - leukocyte count
KW - prognosis
KW - surgery
KW - trachea
KW - treatment
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - CD4+ cells
KW - cell count
KW - human immunodeficiency virus
KW - T4 lymphocytes
KW - tracheostomy
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007236&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occurrence of male-specific bacteriophage in feral and domestic animal wastes, human feces, and human-associated wastewaters.
AU - Calci, K. R.
AU - Burkhardt, W. III
AU - Watkins, W. D.
AU - Rippey, S. R.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1998///
VL - 64
IS - 12
SP - 5027
EP - 5029
SN - 0099-2240
AD - Calci, K. R.: U.S. Public Health Service, Food and Drug Administration, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 19992202281. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Veterinary Science
KW - animal wastes
KW - contamination
KW - faeces
KW - indicators
KW - public health
KW - sewage
KW - water pollution
KW - water quality
KW - USA
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feces
KW - livestock wastes
KW - male-specific bacteriophage
KW - United States of America
KW - water composition and quality
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pollution and Degradation (PP600)
KW - Water Resources (PP200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202281&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes.
AU - Elkins, K. L.
AU - Macintyre, A. T.
AU - Rhinehart-Jones, T. R.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1998///
VL - 66
IS - 7
SP - 3467
EP - 3469
SN - 0019-9567
AD - Elkins, K. L.: Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19980506601. Publication Type: Journal Article. Language: English. Number of References: 15 ref.
N2 - Normal mice, but not lymphocyte-deficient or B-cell-deficient mice, given a sublethal infection of Francisella tularensis live vaccine strain (LVS) survived a secondary lethal challenge of >10 000 50% lethal doses given 3 days later. Here, it is shown that similar early protection that is also strongly lymphocyte dependent operates in Listeria monocytogenes infection. Since sublethal infection with either LVS or L. monocytogenes protects against heterologous lethal challenge, this early protection is nonspecific.
KW - immunity
KW - immunization
KW - laboratory animals
KW - lymphocytes
KW - vaccines
KW - Francisella tularensis
KW - Listeria monocytogenes
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immune sensitization
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506601&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimation of group B streptococcus type III polysaccharide-specific antibody concentrations in human sera is antigen dependent.
AU - Bhushan, R.
AU - Anthony, B. F.
AU - Frasch, C. E.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1998///
VL - 66
IS - 12
SP - 5848
EP - 5853
SN - 0019-9567
AD - Bhushan, R.: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
N1 - Accession Number: 19992004550. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 58-85-5, 308067-58-5, 308067-57-4.
N2 - The presence of immunoglobulin G (IgG) antibodies against group B streptococcus (GBS) type III polysaccharide (PS) has been correlated with protection against GBS disease. The GBS type III PS is structurally similar to the pneumococcal type 14 PS, differing only in the presence of sialic acid residues. Four different preparations of GBS type III PS were evaluated for their specificity in enzyme-linked immunosorbent assay (ELISA): free PS, free PS mixed with methylated human serum albumin (mHSA), PS conjugated to biotin and PS conjugated to human serum albumin. Three groups of human sera were used to evaluate these PS preparations: sera from recipients of a GBS PS vaccine, sera from women receiving a GBS type III PS-tetanus toxoid conjugate vaccine, and sera from nonimmunized healthy women of childbearing age. Estimated antibody concentrations were different depending on the PS preparation used. Using any of the 4 preparations, it was possible to measure ≤0.05 µg of IgG antibody to the GBS type III PS per ml. The specificity of the assay was determined by competitive inhibition with homologous and heterologous PS. The pneumococcal type 14 PS did not inhibit binding of antibody to the native GBS type III PS in sera from adults receiving the GBS PS vaccine or in sera from nonimmunized adults (except serum G9). The pneumococcal type 14 PS inhibited 50% in sera from recipients of GBS type III conjugate vaccine and in serum G9 when GBS type III PS conjugated to biotin or to HSA was used as antigen in ELISA. These data show that free GBS type III PS or PS mixed with mHSA is a sensitive and specific antigen for ELISA and that conjugation can alter the antigenic specificity of a PS.
KW - albumins
KW - antibodies
KW - antigens
KW - assays
KW - biotin
KW - blood serum
KW - ELISA
KW - human diseases
KW - IgG
KW - immunoglobulins
KW - inhibition
KW - polysaccharides
KW - serum albumin
KW - toxoids
KW - transplant recipients
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - complex carbohydrates
KW - enzyme linked immunosorbent assay
KW - gamma-globulins
KW - immune globulins
KW - immunogens
KW - recipients
KW - Host Resistance and Immunity (HH600)
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992004550&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Energy, macronutrient, and food intakes in relation to energy compensation in consumers who drink different types of milk.
AU - Lee, H. H. C.
AU - Gerrior, S. A.
AU - Smith, J. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1998///
VL - 67
IS - 4
SP - 616
EP - 623
SN - 0002-9165
AD - Lee, H. H. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration and Human Nutrition Information Service, US Department of Agriculture, Washington, DC, USA.
N1 - Accession Number: 19981408706. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - To examine whether total fat intake is actually lower in reduced-fat (low-fat and skim) milk drinkers and whether reduced-fat-milk drinkers compensate for energy intake, the intakes of foods, energy and energy-yielding nutrients in reduced-fat-milk drinkers and whole milk drinkers were compared using the US Department of Agriculture's 1989-91 nationwide food intake database, the Continuing Survey of Food Intakes by Individuals. This database represents a national stratified sample population of 15 128 individuals. Of the survey population, approximately one-third consumed whole milk, one-third consumed low-fat milk, one-tenth consumed skim milk and one-tenth consumed mixed types of milk. Total fat intake of reduced-fat-milk drinkers was significantly lower than that of whole milk drinkers. In general, males but not females compensated for energy by increasing their carbohydrate intake. Reduced-fat-milk drinkers consume more fruit and vegetables (P≤0.05) and less red meat and sweets (P≤0.05) than whole milk drinkers. Through their reduction in total fat intake, several age groups of skim milk drinkers have achieved the US dietary goal for fat intake, i.e., ≤30% of energy intake from fat. Teenagers compensated for energy intake the least of all age groups and with advancing age, fewer people drank milk and fewer drank whole milk. The data indicate significant sex differences in energy compensation, that reduced-fat-milk drinkers consume significantly less fat than whole milk drinkers, and that the US dietary goal for fat intake may be practically achieved by consuming reduced-fat foods such as skim milk and limiting intakes of high-fat foods such as red meat.
KW - age
KW - carbohydrates
KW - consumers
KW - consumption
KW - diet studies
KW - energy consumption
KW - fat consumption
KW - fruit
KW - low fat milk
KW - meat
KW - milk
KW - sex differences
KW - skim milk
KW - sweets
KW - vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - energy use
KW - energy utilization
KW - saccharides
KW - United States of America
KW - vegetable crops
KW - Diet Studies (VV110)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981408706&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Iron and zinc interactions in humans.
AU - Whittaker, P.
A2 - Black, R. E.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1998///
VL - 68
SP - 442S
EP - 446S
SN - 0002-9165
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C West Street, SW Washington, DC 20204, USA..
N1 - Accession Number: 19981414449. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Registry Number: 7439-89-6, 7440-66-6. Subject Subsets: Human Nutrition
N2 - This article reviews studies examining the interaction between Zn and Fe. The effects of fortifying foods with Zn and Fe are also discussed.
KW - absorption
KW - food safety
KW - fortification
KW - iron
KW - nutrient nutrient interactions
KW - reviews
KW - supplements
KW - trace elements
KW - zinc
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - microelements
KW - Physiology of Human Nutrition (VV120)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414449&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Strategies on HIV infection in the German Armed Forces.
AU - Häfner, B.
JO - Revue Internationale des Services de Sante des Forces Armees
JF - Revue Internationale des Services de Sante des Forces Armees
Y1 - 1998///
VL - 71
IS - 10/11/12
SP - 305
EP - 309
SN - 0259-8582
AD - Häfner, B.: Office of the Surgeon General, German Armed Forces, Bonn, Germany.
N1 - Accession Number: 19992006043. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French.
N2 - The epidemiological situation regarding HIV infections and cases of AIDS, in the world, in Western Europe, and in the German Armed Forces is considered. The official policy concerning the HIV testing in the military personnel is explained and justified. Documentation is given on preventive measures, health education and care in the preclinical phase and in the clinical phase.
KW - acquired immune deficiency syndrome
KW - Armed Forces
KW - disease prevention
KW - epidemiology
KW - health care
KW - health education
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - military personnel
KW - screening
KW - Germany
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - screening tests
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006043&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenesis of the NS3 protease of dengue virus type 2.
AU - Valle, R. P. C.
AU - Falgout, B.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1998///
VL - 72
IS - 1
SP - 624
EP - 632
SN - 0022-538X
AD - Valle, R. P. C.: Laboratory of Vector-Borne Viral Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20852-1448, USA.
N1 - Accession Number: 19980503101. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 56-41-7. Subject Subsets: Medical & Veterinary Entomology
N2 - A mutational analysis was undertaken of the region of the Flavivirus protein, NS3, which contains the catalytic serine, 5 putative substrate binding residues and several residues that are highly conserved among Flavivirus proteases and among all serine proteases. In all, 46 single-amino-acid substitutions were created in a cloned NS2B-NS3 cDNA fragment of dengue virus type 2, and the effect of each mutation on the extent of self-cleavage of the NS2B-NS3 precursor at the NS2B-NS3 junction was assayed in vivo. 12 mutations almost completely or completely inhibited protease activity, 9 significantly reduced it, 14 decreased cleavage and 11 yielded wild-type levels of activity. Substitution of alanine at ultraconserved residues abolished NS3 protease activity. Cleavage was also inhibited by substituting some residues that are conserved among Flavivirus NS3 proteins. Two (Y150 and G153) of the 5 putative substrate binding residues could not be replaced by alanine, and only Y150 and N152 could be replaced by a conservative change. The 2 other putative substrate binding residues, D129 and F130, were more freely substitutable. By analogy with the trypsin model, it was proposed that D129 is located at the bottom of the substrate binding pocket so as to directly interact with the basic amino acid at the substrate cleavage site. Significant cleavage activity was displayed by mutants in which D129 was replaced by E, S or A and that low but detectable protease activity was exhibited by mutants in which D129 was replaced by K, R or L. It is concluded that, contrary to the proposed model, these results indicate that D129 is not a major determinant of substrate binding and that its interaction with the substrate, if it occurs at all, is not essential. It is concluded that mutations that decrease protease activity without abolishing it are candidates for introduction into the dengue virus infectious full-length cDNA clone to create attenuated virus stocks.
KW - alanine
KW - amino acid sequences
KW - amino acids
KW - arboviruses
KW - cleavage
KW - live vaccines
KW - molecular biology
KW - mutagenesis
KW - mutational analysis
KW - mutations
KW - proteinases
KW - serine proteinases
KW - viral proteins
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - attenuated vaccines
KW - nonstructural proteins
KW - proteases
KW - protein sequences
KW - serine proteases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980503101&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of specific nucleotide sequences within the conserved 3′-SL in the dengue type 2 virus genome required for replication.
AU - Zeng LingLing
AU - Falgout, B.
AU - Markoff, L.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1998///
VL - 72
IS - 9
SP - 7510
EP - 7522
SN - 0022-538X
AD - Zeng LingLing: Laboratory of Vector-Borne Virus Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29A, Rm. 1B17, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19990500240. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - The authors examined the requirement for the thermodynamically stable, conserved short and long stem-and-loop structures (3′-SL) in the context of dengue virus type 2 (DEN2) replication by mutagenesis of an infectious cDNA copy of a DEN2 genome. Genomic full-length RNA was transcribed in vitro and used to transfect monkey kidney cells. A substitution mutation, in which the 3′-terminal 93 nucleotides constituting the wild-type (wt) DEN2 3′-SL sequence were replaced by the 96-nucleotide sequence of the West Nile virus (WN) 3′-SL, was sublethal for virus replication. An analysis of the growth phenotypes of additional mutant viruses derived from RNAs containing DEN2-WN chimaeric 3′-SL structures suggested that the wt DEN2 nucleotide sequence forming the bottom half of the long stem and loop in the 3′-SL was required for viability. One 7-bp substitution mutation in this domain resulted in a mutant virus that grew well in monkey kidney cells, but was severely restricted in cultured Aedes albopictus C6/36 cells. In contrast, transpositions of and/or substitutions in the wt DEN2 nucleotide sequence in the top half of the long stem and in the short stem and loop were relatively well tolerated, provided the stem-loop secondary structure was conserved.
KW - arboviruses
KW - cells
KW - genomes
KW - infectivity
KW - molecular genetics
KW - mutations
KW - nucleotide sequences
KW - replication
KW - RNA
KW - structure
KW - viability
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - biochemical genetics
KW - DNA sequences
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990500240&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cytokine regulation of human immunodeficiency virus type 1 entry and replication in human monocytes/macrophages through modulation of CCR5 expression.
AU - Wang JinHai
AU - Roderiquez, G.
AU - Oravecz, T.
AU - Norcross, M. A.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 1998///
VL - 72
IS - 9
SP - 7642
EP - 7647
SN - 0022-538X
AD - Wang JinHai: Division of Hematologic Products, Center for Biologics Evaluationand Research, Food and Drug Administration, NIH, Bldg 29B, Rm 4E12, HFM-541, Bethesda, MD 20892, USA.
N1 - Accession Number: 19982012048. Publication Type: Journal Article. Language: English. Number of References: 64 ref.
N2 - After culture of monocytes for 48 h in serum-free medium, ~30% of the resulting macrophages expressed CCR5 and the cells were susceptible to infection by macrophage-tropic HIV-1. Addition of either macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) to the cultures markedly increased both the extent of HIV-1 entry and replication as well as surface expression of CCR5. In contrast, addition of the T-helper 2 (Th2) cell-derived cytokine interleukin-4 (IL-4) or IL-13 prevented the expression of CCR5 induced by culture in medium alone, and IL-4 inhibited virus entry, replication, and cytopathicity under these conditions. IL-4 or IL-13 also prevented the stimulatory effects of M-CSF or GM-CSF on CCR5 expression as well as HIV-1 entry and replication. In addition, IL-4 reversed the increase in CCR5 expression induced by pretreatment of cells with M-CSF. Although IL-10 also inhibits HIV-1 replication in macrophages, it did not suppress surface CCR5 expression induced by colony-stimulating factors. These results indicate that the cytokine environment determines the susceptibility of macrophages to HIV-1 infection by various mechanisms, one of which is the regulation of HIV-1 coreceptor expression.
KW - chemokines
KW - colony stimulating factor
KW - cytokines
KW - cytopathogenicity
KW - human diseases
KW - human immunodeficiency viruses
KW - infectivity
KW - macrophages
KW - monocytes
KW - pathogenesis
KW - receptors
KW - replication
KW - susceptibility
KW - viral replication
KW - Human immunodeficiency virus 1
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012048&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breast cancer risk, meat consumption and N-acetyltransferase (NAT2) genetic polymorphisms.
AU - Ambrosone, C. B.
AU - Freudenheim, J. L.
AU - Rashmi Sinha
AU - Graham, S.
AU - Marshall, J. R.
AU - Vena, J. E.
AU - Laughlin, R.
AU - Nemoto, T.
AU - Shields, P. G.
JO - International Journal of Cancer
JF - International Journal of Cancer
Y1 - 1998///
VL - 75
IS - 6
SP - 825
EP - 830
SN - 0020-7136
AD - Ambrosone, C. B.: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR, USA.
N1 - Accession Number: 19991400193. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - The association of ingestion of meat, chicken and fish, as well as particular concentrated sources of heterocyclic amines (HA), with breast cancer risk was investigated. Caucasian women with incident breast cancer (n=740) and community controls (n=810) were interviewed and completed a food frequency questionnaire. A subset of these women (n=793) provided a blood sample. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine N-acetyltransferase (NAT2) genotype. Consumption of red meats, as well as an index of concentrated sources of HA, was not associated with increased breast cancer risk, nor did risk vary by NAT2 genotype. In post-menopausal women, higher fish consumption was inversely associated with risk (odds ratio = 0.7; 95% confidence interval, 0.4-1.0); among pre-menopausal women, there was the suggestion of inverse associations between risk and pork and chicken intake. It was suggested that consumption of meats and other concentrated sources of HA is not associated with increased breast cancer risk. However, due to the strong biological plausibility for a role of some HA in mammary carcinogenesis, and the likely measurement error in evaluation of sources of HA in this study, further studies of these possible relationships are warranted.
KW - amines
KW - chicken meat
KW - diet
KW - enzymes
KW - genetic factors
KW - heterocyclic nitrogen compounds
KW - mammary gland neoplasms
KW - meat
KW - pigmeat
KW - poultry
KW - risk
KW - women
KW - USA
KW - fowls
KW - man
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chickens
KW - domesticated birds
KW - mammary tumour
KW - pork
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Food Science and Food Products (Human) (QQ000)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991400193&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of bioaccumulating polychlorinated naphthalenes and their toxicological significance.
AU - Hayward, D.
JO - Environmental Research
JF - Environmental Research
Y1 - 1998///
VL - 76
IS - 1
SP - 1
EP - 18
AD - Hayward, D.: U.S. Food and Drug Administration, 200 C Street Southwest, Washington, DC 20204, USA.
N1 - Accession Number: 19982206368. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 91-20-3. Subject Subsets: Veterinary Science
KW - naphthalene
KW - organochlorine compounds
KW - pollution
KW - poultry
KW - residues
KW - reviews
KW - toxicology
KW - cattle
KW - fowls
KW - man
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Homo
KW - Hominidae
KW - Primates
KW - chickens
KW - domesticated birds
KW - environmental pollution
KW - organic chlorine compounds
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982206368&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Illegal use of β-adrenergic agonists in the United States.
AU - Mitchell, G. A.
AU - Dunnavan, G.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 1998///
VL - 76
IS - 1
SP - 208
EP - 211
SN - 0021-8812
AD - Mitchell, G. A.: Office of Surveillance & Compliance, Center for Veterinary Medicine, FDA, Rockville, MD 20855, USA.
N1 - Accession Number: 19980102696. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 21898-19-1, 37148-27-9. Subject Subsets: Animal Breeding; Pig Science; Agricultural Biotechnology; Animal Nutrition
N2 - An overview of the history of the use of the β-adrenergic agonist clenbuterol (CBL) in the USA. Symptoms, but no deaths, from CBL residue-induced food poisoning have been reported from investigations of separate events in Spain and France. In 1991, the FDA sent letters to all states and USDA/FSIS advising them of the possibility of illegal CBL use in domestic animals and of concern about adverse effects on public health if residue was present in food. The FDA asked USA Customs to be alert to attempts at illegal importation and to advise that USA authorities were prepared to investigate distribution, sale or use of the drug. Analytical methods are available to assay for CBL residue in edible tissues and in the retinal tissues of the eye. Methods are being developed for assay of non-invasive samples such as hair. Residues of CBL have been found in 1 sample of edible tissue and several samples of retinal tissues from show animals and in some classes of commercial meat-producing animals. Several individuals have been found guilty of distributing CBL; cases are pending and investigations are continuing. It is possible that CBL will be approved for safe conditions of use.
KW - beta-adrenergic agonists
KW - biotechnology
KW - clenbuterol
KW - food poisoning
KW - growth promoters
KW - law
KW - livestock
KW - regulations
KW - USA
KW - Bovidae
KW - cattle
KW - pigs
KW - sheep
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - growth stimulants
KW - hogs
KW - legal aspects
KW - legal principles
KW - rules
KW - swine
KW - United States of America
KW - Meat Producing Animals (LL120)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Laws and Regulations (DD500)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Feed Additives (RR130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980102696&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The epitope stability of Group 1 and Group 2 allergens in mite extracts.
AU - Liu, T.
AU - Lin Yuan
JO - Annals of Allergy, Asthma, & Immunology
JF - Annals of Allergy, Asthma, & Immunology
Y1 - 1998///
VL - 80
IS - 2
SP - 177
EP - 183
AD - Liu, T.: Laboratory of Immunobiochemistry, Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1441, USA.
N1 - Accession Number: 19980504083. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 56-81-5. Subject Subsets: Medical & Veterinary Entomology
N2 - Commercial mite allergenic extracts sold in the USA are prepared with whole body mites in buffer solutions containing 50% glycerol. Mite extracts were reported to contain large number of proteolytic enzymes and their structural integrity in aqueous solutions have not previously been evaluated. The epitope stabilities of Group 1 and 2 allergens in 2 commercial mite extracts used by the Center for Biologics Evaluation and Research (CBER) as reference extracts, E5-Dp (Dermatophagoides pteronyssinus) and E5-Df (D. farinae). Epitope stability was determined by using monoclonal antibodies in a sandwich ELISA. Samples were stored at 4 different temperatures and the amounts of Der p 1, Der p 2, Der f 1, and Der f 2 were determined at different time intervals. The overall stability of mite extracts was evaluated by immunoblot and competition ELISA. The epitope stability of these allergens varies: Der f 1 was stable for at least 3 years and Der f 2 for 1 year when stored at 4°C; Der p 1 and 2 were less stable. None of the Group 1 and 2 allergens remained intact when stored at 50°C. Immunoblot and competition ELISA data also showed similar trend of degradation as compared with extracts stored at 4°C for same length of time. With the exception of Der f 1, the amount of detectable epitopes in Group 1 and 2 allergens reduce rapidly after 1 year, especially at elevated temperatures. The changes in allergen composition were also observed by immunoblotting and in relative potency by ELISA competition assay. These findings are highly relevant to the users of CBER's mite extracts as standards.
KW - allergens
KW - ELISA
KW - enzymes
KW - epitopes
KW - extracts
KW - glycerol
KW - house dust mites
KW - immunoblotting
KW - stability
KW - USA
KW - Acari
KW - Arachnida
KW - Dermatophagoides farinae
KW - Dermatophagoides pteronyssinus
KW - mites
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antigenic determinants
KW - enzyme linked immunosorbent assay
KW - glycerin
KW - glycerine
KW - house dust mite
KW - house-dust mites
KW - housedust mites
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980504083&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acquisition, storage, and review of safety data from a commercial system for high temperature, short time pasteurization.
AU - Schlesser, J. E.
AU - Lynn, G.
AU - Armstrong, D. J.
AU - Cinar, A.
AU - Ramanauskas, P.
AU - Negiz, A.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 1998///
VL - 81
IS - 1
SP - 25
EP - 30
SN - 0022-0302
AD - Schlesser, J. E.: United States Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 19980402243. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - An HTST pasteurization system from a commercial dairy was equipped with electronic sensors to determine the temperature, pressure, flow rate and position of the flow diversion valve. A computer for data acquisition was wired to the sensors to monitor and to record processing conditions related to public health. The processing conditions of the HTST system were monitored for 270 days to determine the accuracy and reliability of the data acquisition system. The size of the HTST safety files ranged from 6.2 to 9.1 MB when the sensors were monitored every second. The file size was reduced to <1.8 MB when the monitoring frequency was increased to every 5 s. To determine accuracy, the temperatures recorded by the data acquisition system were compared with the temperatures recorded by an electronic recorder controller. To determine reliability, changes in the position of the flow diversion valve were examined to identify process deviations and were compared with the event marker on circular charts. The review of the data file by the actual time method was an effective alternative to the electronic recorder controller for monitoring the completeness of data in the safety files. Off-line review to determine reliability required approximately 10 min/day.
KW - analytical methods
KW - computer software
KW - flow
KW - food safety
KW - milk
KW - pasteurization
KW - pasteurizers
KW - pressure
KW - safety
KW - temperature
KW - analytical techniques
KW - computer programs
KW - pasteurizing
KW - Milk and Dairy Produce (QQ010)
KW - Processing Equipment and Technology (NN600)
KW - Automation and Control (NN050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980402243&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Zero control reference materials for infant formula methods development.
AU - Chase, G. W., Jr.
AU - Reid, A. P.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 2
SP - 453
EP - 453
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19980402864. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 59-02-9, 79-81-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - A zero control reference material (ZRM) for the analysis of retinyl palmitate and all-rac-α-tocopherol acetate in milk- and soya-based infant formula was manufactured and characterized. The ZRM was free of retinyl palmitate and all-rac-α-tocopheryl acetate and its composition was similar to commercially available infant formula. It is concluded that the ZRM provides a valuable tool to determine method performance.
KW - alpha-tocopherol
KW - analytical methods
KW - composition
KW - development
KW - infant formulae
KW - methodology
KW - milk
KW - retinyl palmitate
KW - soya protein
KW - vitamins
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - methods
KW - retinol palmitate
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - vitamin A palmitate
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980402864&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in soy-based infant formula using a zero-control reference material (ZRM) as a method development tool.
AU - Chase, G. W., Jr.
AU - Long, A. R.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 3
SP - 577
EP - 581
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19980403698. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Dairy Science; Human Nutrition
N2 - A liquid chromatographic method is described for analysis of all-rac-α-tocopheryl acetate, tocopherols and retinyl palmitate in soya-based infant formula. The vitamins are extracted in isopropyl alcohol and hexane-ethyl acetate without saponification and quantitated by normal-phase chromatography with fluorescence detection. All-rac-α-tocopheryl acetate and retinyl palmitate are quantitated isocratically with mobile phases of 0.5 and 0.125% (v/v) isopropyl alcohol in hexane, respectively. Recoveries from zero control reference material soya-based formula averaged 97.2% (n = 25) for retinyl palmitate and 100% (n = 25) for all-rac-α-tocopheryl acetate. Coefficients of variation ranged from 1.21 to 2.86% for retinyl palmitate and from 1.49 to 5.16% for all-rac-α-tocopheryl acetate. It is concluded that the method provides a rapid, specific and easily controlled assay for analysis of vitamin A and vitamin E in fortified infant formula. Additionally, the method eliminates use of chlorinated solvents.
KW - analytical methods
KW - infant formulae
KW - liquid chromatography
KW - retinol
KW - retinyl palmitate
KW - soyabeans
KW - tocopherols
KW - vitamin E
KW - vitamin E acetate
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - infant formula
KW - infant formulas
KW - retinol palmitate
KW - soybeans
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980403698&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in milk-based infant formula using matrix solid-phase dispersion.
AU - Chase, G. W., Jr.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 3
SP - 582
EP - 586
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19980403699. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Dairy Science; Human Nutrition
N2 - A liquid chromatographic method is described for analysis of all-rac-α-tocopheryl acetate, tocopherols and retinyl palmitate in milk-based infant formula. The vitamins are extracted from infant formula without saponification by matrix solid-phase dispersion and quantitated by normal-phase chromatography with fluorescence detection. Retinyl palmitate and vitamin E are quantitated isocratically with mobile phases of 0.125 and 0.5% (v/v) isopropyl alcohol in hexane, respectively. Results were similar to the certified and non-certified ranges for all-rac-α-tocopheryl acetate, retinyl palmitate and tocopherols in the infant formula standard reference material (SRM) 1846. Results also compared favourably with the label declaration on a retail infant formula. Recoveries were determined on an analyte-fortified zero control reference material for milk-based infant formula and averaged 96.8% (n = 30) for retinyl palmitate and 91.5% (n = 25) for all-rac-α-tocopheryl acetate. Examination of 5 concentrations for each analyte gave results that were linear (r = 0.999) over the concentration examined, with coefficients of variation ranging from 1.02 to 5.86%. The method provides a rapid, specific and easily controlled assay for analysis of retinyl palmitate and vitamin E in fortified infant formula. Additionally, the method minimizes solvent use by using only 14 ml solvent/extraction.
KW - analytical methods
KW - infant formulae
KW - liquid chromatography
KW - milk products
KW - retinol
KW - retinyl palmitate
KW - tocopherols
KW - vitamin E
KW - vitamin E acetate
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - dairy products
KW - infant formula
KW - infant formulas
KW - retinol palmitate
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980403699&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of methylxanthines and catechins in herbal preparations containing guaraná.
AU - Carlson, M.
AU - Thompson, R. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 4
SP - 691
EP - 701
SN - 1060-3271
AD - Carlson, M.: U.S. Food and Drug Administration, 240 Hennepin Ave, Minneapolis, MN 55401, USA.
N1 - Accession Number: 19981414340. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - Methylxanthines and polyphenols are extracted from sample matrix with a heated phosphate buffer-methanol solution, the cooled extract is filtered, and the extract is injected into the liquid chromatographic (LC) system. A Nova-Pak C18 column eluted with phosphate buffer-methanol mobile phase (pH = 3.50) and monitored at 272 nm gave satisfactory resolution for the methylxanthines theobromine, theophylline, caffeine and the polyphenols (+)-catechin and (-)-epicatechin. 24 products including dried seeds, dried paste, seed powders, tablets and capsule formulations were assayed and conclusions were drawn about their authenticity. The LC system responded linearly to methylxanthines over the 100-fold range in concentration from 0.043 to 4.30 µg/ml for theobromine and caffeine and from 0.041 to 4.10 µg/ml for theophylline. Precision data for the 3 methylxanthines obtained from 10 different products (n=5) gave relative standard deviation (RSD) values of 1.18-15.52% within a concentration range of 0.01-52.28 mg/g. Recoveries of methylxanthines from fortified products varied from 87.5 to 120.0%. The response for catechins was linear over a 200-fold range in concentration of 0.05-10.0 µg/ml. Precision data from 5 products (n=5) gave RSD values of 1.08-5.54% within a concentration range of 0.34-32.65 mg/g. Recoveries from these products ranged from 87.7 to 109.7%. Results and chromatographic profiles for 14 commercial products in solid dosage form indicate that a number of these products may not contain authentic guaraná as an active ingredient or contain less than the declared quantity of guaraná. The proposed procedure also was applied to 2 carbonated soft drinks and a sample of maté.
KW - analytical methods
KW - determination
KW - flavanols
KW - liquid chromatography
KW - products
KW - xanthine alkaloids
KW - Paullinia cupana
KW - Paullinia
KW - Sapindaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - guarana
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414340&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of chloramphenicol, florfenicol, and thiamphenicol residues in milk by gas chromatography with electron capture detection.
AU - Pfenning, A. P.
AU - Madson, M. R.
AU - Roybal, J. E.
AU - Turnipseed, S. B.
AU - Gonzales, S. A.
AU - Hurlbut, J. A.
AU - Salmon, G. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 4
SP - 714
EP - 720
SN - 1060-3271
AD - Pfenning, A. P.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 19980405168. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 56-75-7, 73231-34-2, 76639-94-6, 15318-45-3. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science
N2 - A gas chromatographic (GC) method is described for determining residues of chloramphenicol (CAP), florfenicol (FF) and thiamphenicol (TAP) in raw milk using meta-nitrochloramphenicol as the internal standard. Milk was extracted with acetonitrile, centrifuged, evaporated, reconstituted in water, and passed through a C18 solid-phase extraction (SPE) column. The column was eluted with 60% methanol and the eluate was evaporated and derivatized. After derivatization, toluene was added directly to the sample, followed by water, to quench the derivatization process. After centrifugation, the organic layer was carefully removed. Analytes were determined by GC with electron capture detection. Milk samples were spiked with the fenicols at 5, 10, 20, 40 and 80 ng/ml (target level, 10 ng/ml). Overall recoveries were 92, 100 and 104% for CAP, FF and TAP, respectively. Overall interassay (between-day) variabilities were 6.1, 6.7 and 6.0% for CAP, FF and TAP, respectively.
KW - analytical methods
KW - antibiotic residues
KW - chloramphenicol
KW - contamination
KW - drug residues
KW - florfenicol
KW - gas chromatography
KW - milk
KW - thiamphenicol
KW - analytical techniques
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980405168&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of fumonisin B1 and its hydrolysis product in tortillas.
AU - Stack, M. E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 4
SP - 737
EP - 740
SN - 1060-3271
AD - Stack, M. E.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 19981202267. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition
N2 - A liquid chromatographic (LC) method was devised for determining fumonisin B1 (FB1) and the total hydrolysis product of FB1 (HB1) in tortillas collected in the Texas-Mexico border region of Texas, USA. The method used acetonitrile-0.1 M phosphate buffer (pH 3; 1+1) extraction, solid-phase C18 clean-up, o-phthalaldehyde and 2-mercaptoethanol derivatization, and reversed-phase LC. Mean recoveries from tortillas spiked with FB1 and HB1 at 250, 500 and 1000 ng/g were 86.5% for FB1 and 82.6% for HB1. Tortillas (n=54) and masa (n=8) from the Texas-Mexico border were analysed for FB1 and HB1. Mean amounts of FB1 and HB1 in tortillas were 187 and 82 ng/g, respectively. Mean amounts of FB1 and HB1 in masas were 262 and 64 ng/g, respectively. It is concluded that fumonisin B1 and its hydrolysis product are present in tortillas consumed by a population that is experiencing an increased incidence of neural tube defects.
KW - analysis
KW - contamination
KW - estimation
KW - foods
KW - fumonisins
KW - hydrolysis
KW - liquid chromatography
KW - mycotoxins
KW - tortillas
KW - Texas
KW - USA
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - fungal toxins
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202267&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of salicin and related compounds in botanical dietary supplements by liquid chromatography with fluorescence detection.
AU - Luo WenHong
AU - Ang, C. Y. W.
AU - Schmitt, T. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 4
SP - 757
EP - 762
SN - 1060-3271
AD - Luo WenHong: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology and Chemistry, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 19981414341. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 138-52-3, 69-72-7. Subject Subsets: Human Nutrition
N2 - A sensitive and reliable method is described for quantitative determination of salicin (including salicyl alcohol) and salicylic acid in botanical dietary supplements by reversed-phase liquid chromatography (LC) with wavelength-programmed fluorescence detection. One gram sample material was extracted with 20 ml aqueous phosphate buffer (pH 5.0), which was heated in an 80°C water bath for 30 min. After centrifugation and cooling of the extract to room temperature, the supernatant was diluted with additional buffer. A 1 ml portion of diluted extract was mixed with β-glucosidase solution 1 ml (2 mg/ml) and incubated for 40 min in a 37°C water bath. The extract was passed through a 0.45 µm syringe filter and analysed by LC. Limits of quantitation for salicin and salicylic acid were 20 and 1 µg/g, respectively. Recoveries from samples fortified with salicin at 20, 100, and 1000 µg/g and with salicylic acid at 5, 20, and 50 µg/g ranged from 85 to 110%, with standard deviations less than 7%.
KW - detection
KW - fluorescence
KW - food supplements
KW - foods
KW - liquid chromatography
KW - salicin
KW - salicylic acid
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Non-wood Forest Products (KK540)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981414341&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of phosphine residues in whole grains and soybeans by ion chromatography via conversion to phosphate.
AU - Carlson, M.
AU - Thompson, R. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1998///
VL - 81
IS - 6
SP - 1190
EP - 1201
SN - 1060-3271
AD - Carlson, M.: U.S. Food and Drug Administration, 240 Hennepin Ave, Minneapolis, MN 55401, USA.
N1 - Accession Number: 19991101498. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 7803-51-2. Subject Subsets: Agricultural Entomology; Wheat, Barley & Triticale Abstracts; Soyabeans
N2 - A method was developed which converts phosphine (PH3) to orthophosphate and isolates phosphate by ion chromatography (IC) with eluent-suppressed conductivity detection. Recoveries of unbound phosphine were similar to those obtained by an established colorimetric method for barley, maize, oats, rice, rye, wheat grains and soyabeans fortified at 3 levels. Mean recoveries were low (24.1-60.3%) and varied with product type and fortification level. Recoveries of PH3 from previously fumigated products fortified with aluminium phosphide ranged from 19.0% for barley fortified at 0.734 ppm to 88.3% for maize fortified at 1.691 ppm. Precision data from wheat, maize and rice based on replicate analyses (n=4 or 5) gave relative standard deviations of 1.78-4.66% for mean laboratory-fumigated PH3 levels of 0.679-1.309 ppm. Estimated limits of detection (LOD) and quantitation (LOQ) for PH3 were 0.010 µg/g (10 ppb) and 0.0275 µg/g (27.5 ppb) at signal-to-noise ratios (S/N) of 4:1 and 10:1, respectively. A non-chemically suppressed IC system gave an LOD of 0.02 µg/g (20 ppb) and LOQ of 0.055 µg/g (55 ppb) at S/N of 4:1 and 10:1, respectively. Phosphate response was linear over the concentration range of 0.30-10.0 µg P/ml, with a mean correlation coefficient of 0.9988 based on replicate standard curves. The relationship of product composition to recovery from various products was examined.
KW - agricultural entomology
KW - analytical methods
KW - barley
KW - cereal grains
KW - chromatography
KW - fumigant insecticides
KW - insecticide residues
KW - maize
KW - oats
KW - phosphine
KW - rice
KW - rye
KW - soyabeans
KW - stored products
KW - techniques
KW - wheat
KW - Avena sativa
KW - Glycine (Fabaceae)
KW - Hordeum vulgare
KW - Oryza
KW - Secale cereale
KW - Triticum
KW - Zea mays
KW - Avena
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - Hordeum
KW - Secale
KW - Zea
KW - analytical techniques
KW - corn
KW - paddy
KW - soybeans
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991101498&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Attempts to transmit the N-3 strain of Plasmodium fieldi to Aotus monkeys.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Richardson, B. B.
AU - Galland, G. G.
AU - Collins, W. E.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1998///
VL - 84
IS - 1
SP - 195
EP - 197
SN - 0022-3395
AD - Sullivan, J. S.: Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980803185. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Splenectomized Aotus lemurinus griseimembra and A. vociferans monkeys (wild-caught in Colombia and Peru respectively) were exposed to the N-3 strain of Plasmodium fieldi. Neither of 2 A. l. griseimembra exposed by mosquito bite developed parasitaemia. Three A. l. griseimembra inoculated with parasitized erythrocytes from a rhesus monkey had transient low-density parasitaemia. Two A. vociferans inoculated with sporozoites dissected from the salivary glands of Anopheles dirus mosquitoes had abundant exoerythrocytic stages of P. fieldi in sections of liver taken 8 days pi, but no blood-stage infections were observed. It is concluded that A. l. griseimembra is a poor host for the N-3 strain of P. fieldi, but that hepatocytes of A. vociferans are highly susceptible to infection with this strain, suggesting that this species may be a useful experimental host for studies of this stage of the parasite.
KW - animal diseases
KW - disease vectors
KW - exoerythrocytic stages
KW - experimental infection
KW - experimental infections
KW - human diseases
KW - laboratory animals
KW - laboratory mammals
KW - liver
KW - malaria
KW - parasites
KW - Anopheles dirus
KW - Aotus
KW - Aotus lemurinus
KW - Aotus vociferans
KW - Culicidae
KW - Diptera
KW - Plasmodium fieldi
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Aotus
KW - Aotus lemurinus griseimembra
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980803185&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on infections with two strains of Plasmodium inui from Taiwan in rhesus monkeys and different anopheline mosquitoes.
AU - Collins, W. E.
AU - Warren, M.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1998///
VL - 84
IS - 3
SP - 547
EP - 551
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980808638. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 58-14-0. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Two strains of Plasmodium inui originally from Taiwan were studied in rhesus monkeys (Macaca mulatta) and 2 species of anopheline mosquitoes. Maximum parasite counts for 13 intact animals infected with the Taiwan I strain ranged from 22 215 to 760 000/µl (median maximum parasite count = 242 800/µl). Following splenectomy, the maximum parasite count for 9 animals ranged from 160 000 to 2 360 000/µl (median = 1 160 000/µl). Sporozoite transmission was demonstrated via the bites of infected Anopheles dirus mosquitoes and by the intravenous inoculation of sporozoites harvested from the guts of infected A. maculatus. Prepatent periods were 12 and 20 days, respectively. With monkeys infected with the Taiwan II strain, parasite counts in 9 intact animals ranged from 40 882 to 223 686/µl. After splenectomy, maximum parasite counts in 8 monkeys ranged from 96 750 to 1 960 000/µl (median = 840 000/µl). Two transmissions were obtained via the bites of infected A. dirus mosquitoes; prepatent periods were 10 days. Limited studies with progressively increasing doses of pyrimethamine resulted in parasites more resistant to treatment. Rhesus monkeys infected with the Taiwan strains of P. inui could be appropriate models for understanding host-parasite relationships during long-term chronic infection.
KW - disease models
KW - disease transmission
KW - disease vectors
KW - drug resistance
KW - experimental infections
KW - immunocompromised hosts
KW - laboratory animals
KW - malaria
KW - parasitaemia
KW - parasites
KW - pyrimethamine
KW - splenectomy
KW - strains
KW - Anopheles dirus
KW - Anopheles maculatus
KW - Culicidae
KW - Diptera
KW - Macaca mulatta
KW - Plasmodium inui
KW - Primates
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - mosquitoes
KW - parasitemia
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808638&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation of a strain of Plasmodium vivax from Mauritania to New World monkeys and anopheline mosquitoes.
AU - Collins, W. E.
AU - Nguyen-Dinh, P.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Galland, G. G.
AU - Richardson, B. B.
AU - Nesby, S.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1998///
VL - 84
IS - 3
SP - 619
EP - 621
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980808643. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - A strain of Plasmodium vivax from Mauritania was adapted to develop in Aotus lemurinus griseimembra, A. nancymai, Saimiri boliviensis and hybrid Aotus monkeys. Infections were induced via the inoculation of sporozoites dissected from the salivary glands of Anopheles gambiae, A. freeborni and A. stephensi mosquitoes or the intravenous passage of infected erythrocytes. Infections in 3 Aotus l. griseimembra monkeys readily infected mosquitoes. Four reference lines of the Mauritania parasites have been stored frozen.
KW - cryopreservation
KW - disease transmission
KW - disease vectors
KW - erythrocytes
KW - experimental infections
KW - hybrids
KW - laboratory animals
KW - parasites
KW - salivary glands
KW - sporozoites
KW - storage
KW - strains
KW - Mauritania
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Aotus
KW - Aotus lemurinus
KW - Aotus nancymai
KW - Culicidae
KW - Diptera
KW - Plasmodium vivax
KW - Primates
KW - protozoa
KW - Saimiri
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - ACP Countries
KW - Francophone Africa
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - Aotus lemurinus griseimembra
KW - blood red cells
KW - mosquitoes
KW - red blood cells
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808643&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of anti-Trypanosoma cruzi antibody isotype specificities by Western blot in sera from patients with different forms of Chagas' disease.
AU - Morgan, J.
AU - Colley, D. G.
AU - Dias, J. C. P.
AU - Gontijo, E. D.
AU - Bahia-Oliveira, L.
AU - Oliveira, R. C.
AU - Powell, M. R.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1998///
VL - 84
IS - 3
SP - 641
EP - 643
SN - 0022-3395
AD - Morgan, J.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Mailstop F-13, 4770 Buford Highway, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19980808649. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 308067-58-5. Subject Subsets: Protozoology; Tropical Diseases
N2 - A group of chronically infected individuals with different clinical forms of Chagas' disease was studied previously and it was found that the levels of some anti-Trypanosoma cruzi antibody isotypes, as analysed by ELISA, differed among patients with different clinical presentations. The antigen specificity of the IgG1, IgG2, IgG3, IgM and IgA of these patients was examined by Western blot. Binding of particular antigens by some antibody isotypes was more prevalent in some clinical groups compared to others. For example, IgG3 from 13 of 19 (68%) individuals with digestive manifestations bound a 68-kDa antigen, but only 3 of 31 (9%) individuals with cardiac involvement detected this same moiety. Regardless of the clinical group, the profiles of antigens recognized by each antibody isotype differed markedly from the profiles recognized by the other isotypes. The data suggest that overall anti-T. cruzi antibody reactivities may be skewed toward different antigens in individuals with different clinical presentations.
KW - antibodies
KW - antigens
KW - Chagas' disease
KW - clinical aspects
KW - ELISA
KW - human diseases
KW - IgA
KW - IgG
KW - IgM
KW - immunopathology
KW - isotypes
KW - parasites
KW - pathogenesis
KW - Western blotting
KW - man
KW - protozoa
KW - Trypanosoma cruzi
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - antigenicity
KW - clinical picture
KW - enzyme linked immunosorbent assay
KW - immunogens
KW - immunopathogenesis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808649&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevated blood lead levels in children of construction workers.
AU - Whelan, E. A.
AU - Piacitelli, G. M.
AU - Gerwel, B.
AU - Schnorr, T. M.
AU - Mueller, C. A.
AU - Gittleman, J.
AU - Matte, T. D.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998///
VL - 87
IS - 8
SP - 1352
EP - 1355
SN - 0090-0036
AD - Whelan, E. A.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19982006819. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7439-92-1.
N2 - This study examined whether children of lead-exposed construction workers in New Jersey, USA, had higher blood lead levels than neighbourhood control children. During 1994, 29 construction workers were identified from the New Jersey Adult Blood Lead Epidemiology and Surveillance registry. 18 control families were referred by workers. Venous blood samples were collected from 50 children (31 exposed, 19 control subjects) <6 years of age. 26% of workers' children had blood lead levels at or over the Centers for Disease Control and Prevention action level of 0.48 µmol/litre (10 µg/dl), compared with 5% of control children (unadjusted odds ratio=6.1). It is suggested that children of construction workers may be at risk for excessive lead exposure, and that health care providers should assess parental occupation as a possible pathway for lead exposure in young children.
KW - children
KW - construction workers
KW - epidemiology
KW - exposure
KW - families
KW - lead
KW - occupational hazards
KW - parents
KW - New Jersey
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - building workers
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982006819&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers.
AU - Calvert, G. M.
AU - Mueller, C. A.
AU - Fajen, J. M.
AU - Chrislip, D. W.
AU - Russo, J.
AU - Briggle, T.
AU - Fleming, L. E.
AU - Suruda, A. J.
AU - Steenland, K.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998///
VL - 88
IS - 12
SP - 1774
EP - 1780
SN - 0090-0036
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 19991102266. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 74-83-9, 2699-79-8. Subject Subsets: Agricultural Entomology
N2 - This study assessed the health effects associated with occupational exposure to methyl bromide and sulfuryl fluoride among structural fumigation workers. A cross-sectional study of 123 structural fumigation workers and 120 referents in south Florida was conducted. Nerve conduction, vibration, neurobehavioural, visual, olfactory, and renal function testing was included. The median lifetime duration of methyl bromide and sulfuryl fluoride exposure among workers was 1.20 years and 2.85 years, respectively. Sulfuryl fluoride exposure over the year preceding examination was associated with significantly reduced performance on the Pattern Memory Test and on olfactory testing. In addition, fumigation workers had significantly reduced performance on the Santa Ana Dexterity Test of the dominant hand and a nonsignificantly higher prevalence of carpal tunnel syndrome than did the referents. Occupational sulfuryl fluoride exposures may be associated with subclinical effects on the central nervous system, including effects on olfactory and some cognitive functions. However, no widespread pattern of cognitive deficits was observed. The peripheral nerve effects were likely to be caused by ergonomic stresses experienced by the fumigation workers.
KW - agricultural entomology
KW - environment
KW - fumigants
KW - health hazards
KW - insecticide residues
KW - insecticides
KW - methyl bromide
KW - nervous system
KW - nontarget effects
KW - pesticides
KW - safety at work
KW - sulfuryl fluoride
KW - Florida
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - bromomethane
KW - occupational safety
KW - sulphuryl fluoride
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991102266&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Species and strain-specific typing of Cryptosporidium parasites in clinical and environmental samples.
AU - Xiao LiHua
AU - Sulaiman, I.
AU - Fayer, R.
AU - Lal, A. A.
JO - Memórias do Instituto Oswaldo Cruz
JF - Memórias do Instituto Oswaldo Cruz
Y1 - 1998///
VL - 93
IS - 5
SP - 687
EP - 692
SN - 0074-0276
AD - Xiao LiHua: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19990802959. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology
N2 - Phylogenetic analysis of the small subunit ribosomal RNA (SSU rRNA) gene has shown that the genus Cryptosporidium comprises several distinct species. Phylogenetic analysis of 4 species: C. parvum, C. muris, C. baileyi and C. serpentis revealed some sequence variation within species. For example, human C. parvum differed from bovine isolates in 4 regions of the SSU rRNA gene. Information on polymorphism in Cryptosporidium parasites has been used in the development of species and strain-specific diagnostic tools. Use of these tools in the characterization of oocysts in various samples indicates that C. parvum genotype 1 is the strain responsible for most human Cryptosporidium infections. In contrast, genotype 2 is probably one of the major sources for environmental contamination, and has been found in most oysters examined from Chesapeake Bay, USA, that may serve as biological monitors of estuarine waters.
KW - diagnosis
KW - genetic polymorphism
KW - genetic variation
KW - genotypes
KW - molecular taxonomy
KW - oocysts
KW - oysters
KW - parasites
KW - phylogeny
KW - ribosomal RNA
KW - strains
KW - waterborne diseases
KW - Cryptosporidium baileyi
KW - Cryptosporidium muris
KW - Cryptosporidium parvum
KW - protozoa
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - Cryptosporidium serpentis
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - rRNA
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802959&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The evolution of primate malaria parasites based on the gene encoding cytochrome b from the linear mitochondrial genome.
AU - Escalante, A. A.
AU - Freeland, D. E.
AU - Collins, W. E.
AU - Lal, A. A.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 1998///
VL - 95
IS - 14
SP - 8124
EP - 8129
SN - 0027-8424
AD - Escalante, A. A.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Mail Stop F-12, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980806537. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Registry Number: 9035-37-4. Subject Subsets: Protozoology
N2 - A phylogenetic analysis of primate malaria parasites based on the gene encoding the cytochrome b protein from the mitochondrial genome is presented. The study included 17 species of Plasmodium, of which 14 are parasitic in primates. Four species were used for rooting the Plasmodium phylogenetic tree: 2 from closely related genera (Hepatocystis sp. and Haemoproteus columbae) and 2 other Apicomplexa (Toxoplasma gondii and Theileria parva). It was found that primate malaria parasites form a monophyletic group, the only exception being the P. falciparum-P. reichenowi lineage. Phylogenetic analyses that include 2 species of non-Plasmodium Haemosporina suggest that the genus Plasmodium is polyphyletic. It was concluded that biological traits such as periodicity and the capacity to relapse have limited value for assessing the phylogenetic relationships among Plasmodium species. No evidence was found to link virulence with the age of the host-parasite association. The study indicated that primate malaria parasites originated in Africa, contradicting the current opinion that southeast Asia is the centre of origin. It is proposed that the radiation of Asian monkey parasites is a recent event where several life history traits, such as differences in periodicity, appeared de novo.
KW - cytochrome b
KW - evolution
KW - genes
KW - genomes
KW - host parasite relationships
KW - malaria
KW - mitochondria
KW - parasites
KW - phylogeny
KW - virulence
KW - Apicomplexa
KW - Haemoproteus columbae
KW - Hepatocystis
KW - Plasmodium
KW - Plasmodium falciparum
KW - Primates
KW - protozoa
KW - Theileria parva
KW - Toxoplasma gondii
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Haemoproteus
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Plasmodium
KW - mammals
KW - vertebrates
KW - Chordata
KW - Theileria
KW - Theileriidae
KW - Piroplasmorida
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - parasite host relationships
KW - Plasmodium reichenowi
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806537&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential hazards of probiotic bacteria for immunodeficient patients.
AU - Wagner, R. D.
AU - Balish, E.
JO - Bulletin de l'Institut Pasteur
JF - Bulletin de l'Institut Pasteur
Y1 - 1998///
VL - 96
IS - 3
SP - 165
EP - 170
AD - Wagner, R. D.: National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 19981415270. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Potential hazards discussed in this review include the close relation of some probiotic species to bacteria that are opportunistic pathogens; the transference of antibiotic resistance genes to other bacteria; and the induction of inflammatory diseases. Alternatives to viable probiotics are suggested. It is concluded that the safety, efficacy, benefits and costs of feeding probiotic bacteria to immunodeficient patients needs to be carefully considered and fully researched to assure they will not cause infectious, inflammatory or autoimmune diseases in these susceptible hosts.
KW - antibiotics
KW - drug resistance
KW - gene transfer
KW - immunological deficiency
KW - inflammation
KW - pathogens
KW - probiotics
KW - reviews
KW - safety
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune deficiency
KW - immunodeficiency
KW - Physiology of Human Nutrition (VV120)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute encephalopathy followed by permanent brain injury or death associated with further attenuated measles vaccines: a review of claims submitted to the National Vaccine Injury Compensation Program.
AU - Weibel, R. E.
AU - Caserta, V.
AU - Benor, D. E.
AU - Evans, G.
JO - Pediatrics
JF - Pediatrics
Y1 - 1998///
VL - 101
IS - 3
SP - 383
EP - 387
SN - 0031-4005
AD - Weibel, R. E.: Division of Vaccine Injury Compensation, National Vaccine Injury Compensation Program, Health Resources and Services Administration, Public Health Service, Rockville, Maryland, USA.
N1 - Accession Number: 19982007605. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - Evidence was sought for a causal relationship between acute encephalopathy followed by permanent brain injury or death associated with the administration of further attenuated measles vaccines, mumps vaccine, or rubella vaccines, combined measles and rubella vaccine, or combined measles, mumps, and rubella vaccine. Claims submitted to the National Vaccine Injury Compensation Program (USA) were reviewed. The medical records of children who met the inclusion criteria of receiving the first dose of these vaccines between 1970 and 1993 and who developed such an encephalopathy with no determined cause within 15 days were identified and analysed. 48 children, ages 10 to 49 months, met the inclusion criteria after receiving measles vaccine, alone or in combination. Eight children died and the remainder had mental regression and retardation, chronic seizures, motor and sensory deficits and movement disorders. The onset of neurological signs or symptoms occurred with a nonrandom, significant distribution of cases on days 8 and 9. No cases were identified after the administration of monovalent mumps or rubella vaccine. It was concluded that this clustering suggests that a causal relationship between measles vaccine and encephalopathy may exist as a rare complication of measles immunization.
KW - adverse effects
KW - children
KW - combined vaccines
KW - death
KW - encephalopathy
KW - human diseases
KW - immunization
KW - measles
KW - mumps
KW - reviews
KW - rubella
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - measles virus
KW - mumps virus
KW - rubella virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Rubulavirus
KW - Rubivirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - German measles
KW - immune sensitization
KW - mixed vaccines
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982007605&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risky business: challenges in vaccine risk communication.
AU - Ball, L. K.
AU - Evans, G.
AU - Bostrom, A.
JO - Pediatrics
JF - Pediatrics
Y1 - 1998///
VL - 101
IS - 3
SP - 453
EP - 458
SN - 0031-4005
AD - Ball, L. K.: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 19982008264. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Public Health
N2 - This special article aims to help physicians to improve their ability to discuss vaccine risks, by presenting a historical perspective of vaccine adverse events and applying lessons from research into risk communication.
KW - adverse effects
KW - children
KW - communication
KW - history
KW - human diseases
KW - immunization
KW - infectious diseases
KW - research
KW - risk
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - communicable diseases
KW - immune sensitization
KW - studies
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008264&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a bicycle helmet giveaway program - Texas, 1995.
AU - Logan, P.
AU - Leadbetter, S.
AU - Gibson, R. E.
AU - Schieber, R.
AU - Branche, C.
AU - Bender, P.
AU - Zane, D.
AU - Humphreys, J.
AU - Anderson, S.
JO - Pediatrics
JF - Pediatrics
Y1 - 1998///
VL - 101
IS - 4
SP - 578
EP - 582
SN - 0031-4005
AD - Logan, P.: National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 19981808428. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Leisure, Recreation, Tourism
N2 - In 1995, a bicycle helmet give away programme was conducted in two rural towns in Texas, USA. Helmets were given to all 403 school children in kindergarten through grade 8. Helmet education, a bicycle rodeo, and incentives to increase helmet use were part of the programme. Observations of helmet use were made before the helmet programme began and after the programme at several intervals throughout the school year and during the summer. A self-reported survey questionnaire was administered to children in grades 4 through 8 before the helmet programme began and at several intervals during the school year to determine their attitudes about helmet use, safety perceptions, and peer pressure and yielded 179 responses. A questionnaire also was administered to the parents of these children to determine attitudes and bicycle helmet use among a sample of 30 parents. Helmet use increased from 3% before the give away to 38% at the end of the school year, 7 months later. However, during the subsequent summer, helmet use decreased to 5%. Helmet use among 7th- and 8th-grade students was 0% at all observations periods after the give away. Most parents believed that helmets increased riding safety and should be worn, but only 23% reported always wearing one when riding a bicycle. Bicycle helmet give away programmes can increase helmet use temporarily, but they may not be sufficient to sustain it. This programme was not effective among 7th- and 8th-grade students.
KW - adolescents
KW - attitudes
KW - bicycling
KW - children
KW - protective clothing
KW - public opinion
KW - safety
KW - Texas
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - teenagers
KW - United States of America
KW - Recreation and Sport (UU620) (Discontinued March 2000)
KW - Social Psychology and Culture (UU490) (Discontinued March 2000)
KW - Human Injuries (VV610) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981808428&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Peroxidation of membrane lipids and oxidative DNA damage by fumonisin B1 in isolated rat liver nuclei.
AU - Sahu, S. C.
AU - Eppley, R. M.
AU - Page, S. W.
AU - Gray, G. C.
AU - Barton, C. N.
AU - O'Donnell, M. W.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 1998///
VL - 125
IS - 1-2
SP - 117
EP - 121
SN - 0304-3835
AD - Sahu, S. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19981202741. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Mycology
N2 - A model system of isolated rat liver nuclei was used to determine the effects of fumonisin B1 (FB1) on nuclear membrane lipids and DNA. Results suggested that FB1 induced lipid peroxidation concurrently with DNA strand breaks in this in vitro system. Iron and copper had no statistically significant stimulatory effects on these reactions. In addition, the active oxygen scavengers catalase, superoxide dismutase (SOD), mannitol and sodium azide had no significant inhibitory effects on the FB1-induced DNA strand breaks. However, a small but significant reduction in lipid peroxidation by catalase and mannitol was observed. These results suggested that hydroxyl radicals may be the initiators of the nuclear membrane lipid peroxidation, which results in production of peroxyl radicals, which may be responsible for the DNA strand breaks. An alternative explanation is that the hydroxyl radicals, produced close to the DNA-bound metal ions, may induce direct site-specific strand breaks, which are insensitive to the scavengers of active oxygen.
KW - carcinogenesis
KW - DNA
KW - fumonisins
KW - lipid peroxidation
KW - lipids
KW - liver
KW - mycotoxins
KW - poisoning
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - fungal toxins
KW - lipins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981202741&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats.
AU - Kim MeehYe
AU - Shin HyunKyung
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1998///
VL - 128
IS - 10
SP - 1731
EP - 1736
SN - 0022-3166
AD - Kim MeehYe: Division of Toxic Metals, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 19991413675. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 57-88-5, 9005-80-5, 79-09-4. Subject Subsets: Human Nutrition
N2 - Sprague-Dawley rats (n = 32) were fed diets without fibre (control) or containing 1 or 5% chicory extract or 5% inulin for 4 weeks; 0.2% cholesterol was added to all diets. Rats fed chicory extract and inulin diets had significantly higher serum high density lipoprotein (HDL) cholesterol and generally lower low density lipoprotein (LDL) cholesterol concentrations, thus significantly greater ratios of HDL/LDL cholesterol compared with the controls (P < 0.05). The serum apolipoprotein B/apolipoprotein A-1 ratio was significantly lower in rats fed diets containing chicory extract or inulin than that in rats fed fiber-free diets, due to significant reductions in apolipoprotein B concentration (P < 0.05). Greater liver lipid and triglyceride concentrations were observed in rats fed chicory extract or inulin diets compared with the controls (P < 0.05). However, liver phospholipid and cholesterol concentrations were not significantly different among groups (P > 0.05). Addition of 5% inulin to the diet resulted in greater caecal weight, whereas both 5% chicory extract and 5% inulin resulted in greater caecal propionic acid concentration compared with the controls (P < 0.05). Rats fed chicory extract and inulin had significantly greater faecal lipid, cholesterol and bile acid excretions than those fed fibre-free diets (P < 0.05). The results of this study suggest that the improved lipid metabolism observed in rats fed chicory extract (mainly inulin component) may be caused by an alteration in the absorption and/or synthesis of cholesterol, which might result from the changes in caecal fermentation, and by an increase in the faecal excretion of lipid, cholesterol and bile acid.
KW - absorption
KW - bile
KW - bile acids
KW - blood lipids
KW - caecum
KW - chicory
KW - cholesterol
KW - diets
KW - excretion
KW - extracts
KW - faeces
KW - fermentation
KW - fibre
KW - high density lipoprotein
KW - inulin
KW - lipid metabolism
KW - lipids
KW - lipoproteins
KW - liver
KW - low density lipoprotein
KW - phospholipids
KW - propionic acid
KW - ratios
KW - serum
KW - short chain fatty acids
KW - synthesis
KW - Cichorium intybus
KW - rats
KW - Cichorium
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cecum
KW - fat metabolism
KW - feces
KW - fiber
KW - gall
KW - lipins
KW - propanoic acid
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413675&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ultraviolet therapy and patients with HIV infection.
AU - Zmudzka, B. Z.
AU - Beer, J. Z.
JO - Archives of Dermatology
JF - Archives of Dermatology
Y1 - 1998///
VL - 134
IS - 8
SP - 1025
EP - 1026
SN - 0003-987X
AD - Zmudzka, B. Z.: Center for Devices and Radiological Health, Food and Drug Administration, HFZ-114, 9200 Corporate Blvd, Rockville, MD 20850, USA.
N1 - Accession Number: 19982012338. Publication Type: Journal Article. Language: English. Number of References: 16 ref.
KW - antiviral properties
KW - human diseases
KW - human immunodeficiency viruses
KW - infection
KW - therapy
KW - ultraviolet radiation
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-viral properties
KW - human immunodeficiency virus
KW - therapeutics
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982012338&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure to environmental tobacco smoke and risk factors for heart disease among never smokers in the Third National Health and Nutrition Examination Survey.
AU - Steenland, K.
AU - Sieber, K.
AU - Etzel, R. A.
AU - Pechacek, T.
AU - Maurer, K.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 1998///
VL - 147
IS - 10
SP - 932
EP - 939
SN - 0002-9262
AD - Steenland, K.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 19981416517. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - This study examined 3338 never-smoking adults (≥17 years old) who were representative of all US never smokers, in the 1988-1991 Third National Health and Nutrition Examination Survey (NHANES III) to determine whether selected risk factors for heart disease differ between environmental tobacco smoke (ETS)-exposed and -nonexposed persons. Self-reported ETS exposure (at home and at work) and serum cotinine concentrations were available, the latter reflecting recent ETS exposure. After adjustments were made for age, sex, race and education, no significant differences were found between the ETS exposed and the nonexposed for any of 13 cardiovascular risk factors with the exception of dietary carotene, which was lower among the exposed. However, significant positive linear trends were found between serum cotinine and two risk factors (body mass index and alcohol consumption), and significant inverse trends were found with dietary carotene. There were also few differences between exposed and nonexposed never smokers among adults aged 40 years or older, who are most at risk of heart disease. In this group, however, there was an inverse linear trend between serum cotinine and HDL cholesterol (P<0.001). It was suggested that this finding could result from ETS exposure rather than be an indication of confounding; a similar inverse trend was found for children, confirming other results in the literature. It was concluded that these data suggest little potential for confounding by the heart disease risk factors studied here when ETS exposure is determined by self-report.
KW - alcoholic beverages
KW - cardiovascular diseases
KW - carotenes
KW - cholesterol
KW - diet
KW - health
KW - high density lipoprotein
KW - lipoproteins
KW - nutrition
KW - pollution
KW - risk factors
KW - tobacco smoking
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - environmental pollution
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981416517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum.
AU - Escalante, A. A.
AU - Lal, A. A.
AU - Ayala, F. J.
JO - Genetics
JF - Genetics
Y1 - 1998///
VL - 149
IS - 1
SP - 189
EP - 202
SN - 0016-6731
AD - Escalante, A. A.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Chamblee, GA 30341, USA.
N1 - Accession Number: 19980808802. Publication Type: Journal Article. Language: English. Number of References: 121 ref. Subject Subsets: Protozoology
N2 - The genetic polymorphism at 10 Plasmodium falciparum loci that are considered potential targets for specific antimalarial vaccines was studied. The polymorphism was unevenly distributed among the loci: loci encoding proteins expressed on the surface of the sporozoite or the merozoite (AMA-1, CSP, LSA-1, MSP-1, MSP-2 and MSP-3) were more polymorphic than those expressed during the sexual stages or inside the parasite (EBA-175, Pfs25, PF48/45, and RAP-1). Comparison of synonymous and nonsynonymous substitutions indicated that natural selection may account for the polymorphism observed at 7 of the 10 loci studied. This inference depends on the assumption that synonymous substitutions are neutral, which was tested by analysing codon bias and G+C content in a set of 92 gene loci. Evidence was found for an overall trend towards increasing A+T richness, but no evidence for mutation bias. Although the neutrality of synonymous substitutions is not definitely established, this trend towards an A+T rich genome could not explain the accumulation of substitutions at least in the case of 4 genes (AMA-1, CSP, LSA-1 and PF48/45) because the G<-->C transversions are more frequent than expected. Moreover, the Tajima test manifested positive natural selection for the MSP-1 and, less strongly, MSP-3 polymorphisms: the McDonald-Kreitman test manifested natural selection at LSA-1 and PF48/45. It is concluded that there is definite evidence for positive natural selection in the genes encoding AMA-1, CSP, LSA-1, MSP-1 and Pfs48/45. For 4 other loci, EBA-175, MSP-2, MSP-3, and RAP-1, the evidence is limited. No evidence for natural selection was found for Pfs25.
KW - genes
KW - genetic polymorphism
KW - merozoites
KW - molecular genetics
KW - natural selection
KW - parasites
KW - sporozoites
KW - surface proteins
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - membrane proteins
KW - sexual stages
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980808802&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Navajo use of native healers.
AU - Kim, C.
AU - Kwok, Y. S.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 1998///
VL - 158
IS - 20
SP - 2245
EP - 2249
SN - 0003-9926
AD - Kim, C.: US Public Health Service, Box 1938, Crownpoint, NM 87313, USA.
N1 - Accession Number: 19992001625. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - The prevalence of native healer use, reasons for use, cost of use, and the nature of any conflict with conventional medicine were determined by a cross-sectional interview of 300 Navajo patients seen consecutively in an ambulatory care clinic at a rural Indian Health Service hospital in New Mexico, USA, during June-September, 1997. 62% of Navajo patients had used native healers and 39% used native healers on a regular basis; users were not distinguishable from nonusers by age, education, income, fluency in English, identification of a primary provider, or compliance, but Pentecostal patients used native healers less than patients of other faiths. Patients consulted native healers for common medical conditions such as arthritis, depression and diabetes mellitus as well as "bad luck." Perceived conflict between native healer advice and medical provider advice was rare. Cost was the main barrier to seeking native healer care. It is concluded that, among the Navajo, use of native healers for medical conditions is common and is not related to age, sex, or income but is inversely correlated with the Pentecostal faith; use of healers overlaps with use of medical providers for common medical conditions. Patients are willing to discuss use of native healers and rarely perceive conflict between native healer and conventional medicine.
KW - American indians
KW - arthritis
KW - diabetes
KW - ethnic groups
KW - health care
KW - human diseases
KW - Navajo indians
KW - rural areas
KW - traditional medicine
KW - New Mexico
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - folk medicine
KW - United States of America
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992001625&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection.
AU - Zaitseva, M. B.
AU - Lee, S.
AU - Rabin, R. L.
AU - Tiffany, H. L.
AU - Farber, J. M.
AU - Peden, K. W. C.
AU - Murphy, P. M.
AU - Golding, H.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1998///
VL - 161
IS - 6
SP - 3103
EP - 3113
SN - 0022-1767
AD - Zaitseva, M. B.: Division of Viral Products, Food and Drug Administration, Center for Biologics Evaluation and Research, Building 29B, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 19982013723. Publication Type: Journal Article. Language: English. Number of References: 58 ref.
N2 - Infection of immature thymocytes by the T-tropic HIV-1 strain LAI was 10-fold more efficient than that in mature thymocytes, consistent with their relative CXCR4 surface expression. Anti-CXCR4 antiserum or SDF-1 blocked fusion of thymocytes with cells expressing the LAI envelope. In contrast to CXCR4, CCR5 was detected at low levels on thymocytes, and CCR5 agonists did not induce calcium flux or chemotaxis in thymocytes. However, CD4+ mature thymocytes were productively infected with the CCR5-tropic strain Ba-L, and this infection was specifically inhibited with the CCR5 agonist, macrophage inflammatory protein-1β. The data provide strong evidence that CXCR4 and CCR5 function as coreceptors for HIV-1 infection of human thymocytes.
KW - chemokines
KW - chemotaxis
KW - cytokines
KW - human diseases
KW - immune serum
KW - macrophages
KW - pathogenesis
KW - receptors
KW - thymocytes
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - antiserum
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013723&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Splenic cytokine responses in Indian kala-azar before and after treatment.
AU - Kenney, R. T.
AU - Sacks, D. L.
AU - Gam, A. A.
AU - Murray, H. W.
AU - Shyam Sundar
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1998///
VL - 177
IS - 3
SP - 815
EP - 819
SN - 0022-1899
AD - Kenney, R. T.: Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA.
N1 - Accession Number: 19980806492. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 1397-89-3, 12550-17-3, 9008-11-1, 130068-27-8, 207137-56-2. Subject Subsets: Protozoology; Tropical Diseases
N2 - Cytokine messenger RNA (mRNA) levels were measured in serial splenic aspirates from 27 patients with visceral leishmaniasis (Leishmania donovani) during monotherapy with interferon (IFN)-γ (9 patients), sodium antimony gluconate (SAG; 8 patients), or amphotericin B lipid complex (ABLC; 10 patients) in Varanasi, India. At baseline, mRNA for IFN-γ was detected in 18 (86%) of 21 patients, and mRNA for interleukin (IL)-10 and IL-4 was detected in 21 (100%) and 10 (48%) of 21 patients, respectively. With IFN-γ treatment alone, levels of IFN-γ mRNA decreased by day 10 and then returned to baseline levels; IL-10 mRNA levels were high throughout treatment. In the SAG and ABLC groups, levels of IFN-γ and IL-10 mRNA decreased significantly. It is concluded that polarized Th2 cell type responses do not appear to develop in Indian kala-azar; instead, there is an initial mixed Th1-Th2 cell response. With successful treatment and resolution of infection, both components of the immune response appear to involute.
KW - amphotericin B
KW - antimony sodium gluconate
KW - antiprotozoal agents
KW - cytokines
KW - drug therapy
KW - human diseases
KW - immune response
KW - interferon
KW - interleukin 10
KW - interleukin 4
KW - kala azar
KW - messenger RNA
KW - parasites
KW - spleen
KW - visceral leishmaniasis
KW - India
KW - Leishmania donovani
KW - man
KW - protozoa
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - chemotherapy
KW - immunity reactions
KW - immunological reactions
KW - mRNA
KW - sodium antimony gluconate
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980806492&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: a randomized, double-blind, placebo-controlled trial.
AU - Niu, M. T.
AU - Bethel, J.
AU - Holodniy, M.
AU - Standiford, H. C.
AU - Schnittman, S. M.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1998///
VL - 178
IS - 1
SP - 80
EP - 91
SN - 0022-1899
AD - Niu, M. T.: Division of Biostatistics and Epidemiology, Center for Biologic Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM-210, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19982009697. Publication Type: Journal Article. Language: English. Number of References: 77 ref. Registry Number: 30516-87-1.
N2 - A multicentre, double-blind, placebo-controlled trial randomized 28 patients with primary (acute) HIV-1 infection (PHI) to receive zidovudine, 1000 mg daily, or placebo for 24 weeks. At week 48, compared with placebo patients, zidovudine-treated patients had significantly higher CD4+ cell counts (zidovudine, 666 cells/µl; placebo, 362; P = 0.004) and lower peripheral blood mononuclear cell (PBMC) culture titres (zidovudine, 0.58 log infectious units per million cells; placebo, 1.68; P = 0.02) but no difference in plasma RNA (zidovudine, 3.93 log copies/ml; placebo, 4.00; P = 0.83).
KW - antiviral agents
KW - clinical trials
KW - drug therapy
KW - human diseases
KW - zidovudine
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AZT
KW - chemotherapy
KW - human immunodeficiency virus type 1
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982009697&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Campylobacter jejuni in foods.
AU - Altekruse, S. F.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1998///
VL - 213
IS - 12
SP - 1734
EP - 1735
SN - 0003-1488
AD - Altekruse, S. F.: FDA-Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992202842. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 8 ref. Subject Subsets: Veterinary Science
KW - disease transmission
KW - drug resistance
KW - food hygiene
KW - food microbiology
KW - public health
KW - USA
KW - Campylobacter jejuni
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202842&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The issues of residues and human health.
AU - Paige, J. C.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1998///
VL - 213
IS - 12
SP - 1735
EP - 1736
SN - 0003-1488
AD - Paige, J. C.: FDA-Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992202843. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 8 ref. Subject Subsets: Veterinary Science
KW - drug residues
KW - drug resistance
KW - food hygiene
KW - public health
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202843&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The President's national food safety initiative.
AU - Miller, M. A.
AU - Altekruse, S. F.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 1998///
VL - 213
IS - 12
SP - 1737
EP - 1739
SN - 0003-1488
AD - Miller, M. A.: FDA-Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992202844. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 8 ref. Subject Subsets: Veterinary Science
KW - drug resistance
KW - food hygiene
KW - food microbiology
KW - public health
KW - Salmonella enteritidis
KW - Salmonella typhimurium
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - bacterium
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992202844&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Third international conference on phytoestrogens.
A2 - Sheehan, D. M.
T2 - Proceedings of the Society for Experimental Biology and Medicine
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1998///
VL - 217
IS - 3
SP - 239
EP - 396
SN - 0037-9727
AD - National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19981406085. Publication Type: Conference proceedings. Language: English. Number of References: many ref. Subject Subsets: Horticultural Science; Human Nutrition
N2 - This special issue presents the proceedings of the Third International Conference on Phytoestrogens, Jefferson, USA, December 3-6, 1995. The conference facilitated the presentation and discussion of recent findings in phytoestrogen research and all 22 papers are presented in this issue. The general aim of the conference was to investigate the exposure of the human population to plant chemicals with oestrogen activity.
KW - exposure
KW - health
KW - oestrogens
KW - plant oestrogens
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrogens
KW - phytoestrogens
KW - plant estrogens
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Nutrition (General) (VV100)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19981406085&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Herbal medicines, phytoestrogens and toxicity: risk:benefit considerations.
AU - Sheehan, D. M.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1998///
VL - 217
IS - 3
SP - 379
EP - 385
SN - 0037-9727
AD - Sheehan, D. M.: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, DHHS, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19980305317. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 65 ref. Subject Subsets: Horticultural Science; Human Nutrition; Soyabeans
N2 - There are several suggested health benefits of phytoestrogens, particularly those found in soya products. Herbal medicines are also widely thought to confer health benefits. Additionally, drugs are prescribed to improve human health, but unlike phytoestrogens and herbal medicines, toxicities are defined in experimental animals and monitored in humans before and after marketing. Knowledge of toxicity is crucial to decrease the risk:benefit ratio; this knowledge defines appropriate conditions for use and strategies for development of safer products. However, awareness of the toxicity of herbal medicines and phytoestrogen-containing foods is dramatically limited compared with drugs. Some aspects of the toxicity of herbal medicines are briefly reviewed; it is concluded that virtually all of this knowledge is derived from human exposures leading to acute toxicities. Importantly, detection of toxicity is sporadic, and little information is available from prior animal experimentation. Additionally, well-organized monitoring of human populations (as occurs for drugs) is virtually non-existent. Important toxicities with long latencies are particularly difficult to associate with a causative agent during or even after large scale exposures, as exemplified by tobacco smoking and lung cancer; oestrogen replacement therapy and endometrial cancer; diethylstilboestrol and reproductive tract cancers; and foetal alcohol exposure and birth defects. These considerations suggest that much closer study in experimental animals and human populations exposed to phytoestrogen-containing products, and particularly soya-based foods, is necessary. Among human exposure, infant soya formula exposure appears to provide the highest of all phytoestrogen doses, and this occurs during development, often the most sensitive life stage for induction of toxicity. Large, carefully controlled studies in this exposed infant population are a high priority.
KW - adverse effects
KW - drugs
KW - foods
KW - herbal drugs
KW - infants
KW - medicinal plants
KW - monitoring
KW - plant oestrogens
KW - reviews
KW - soyabeans
KW - toxicity
KW - toxicology
KW - animals
KW - Glycine (Fabaceae)
KW - man
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - adverse reactions
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - medicines
KW - officinal plants
KW - pharmaceuticals
KW - phytoestrogens
KW - plant estrogens
KW - soybeans
KW - surveillance systems
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980305317&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monoclonal antibody mapping of the envelope glycoprotein of the dengue 2 virus, Jamaica.
AU - Roehrig, J. T.
AU - Bolin, R. A.
AU - Kelly, R. G.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1998///
VL - 246
IS - 2
SP - 317
EP - 328
SN - 0042-6822
AD - Roehrig, J. T.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19980506479. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A report is given of the isolation and characterization of a set of dengue (DEN) 2 virus-elicited IgG MAbs, used to document the antigenic structure of the dengue (DEN) virus envelope (E) glycoprotein. The monoclonal antibodies (MAbs) were used to map more precisely the biologically important epitopes and domains on the DEN-2 virus E glycoprotein. 16 independent epitopes and 3 functional domains were identified. The results were very similar to those determined for tickborne encephalitis virus. It is concluded that this expanded understanding of the DEN-2 virus E-glycoprotein structure and the availability of these well-characterized anti-DEN MAbs should be useful in DEN virus vaccine design.
KW - arboviruses
KW - biochemistry
KW - characterization
KW - dengue
KW - envelope glycoproteins
KW - epitopes
KW - glycoproteins
KW - human diseases
KW - isolation
KW - monoclonal antibodies
KW - structure
KW - viral proteins
KW - Jamaica
KW - dengue 2 virus
KW - dengue virus
KW - man
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Caribbean Community
KW - Commonwealth of Nations
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Threshold Countries
KW - antigenic determinants
KW - arthropod-borne viruses
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980506479&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emergence of epidemic o'nyong-nyong fever in Uganda after a 35-year absence: genetic characterization of the virus.
AU - Lanciotti, R. S.
AU - Ludwig, M. L.
AU - Rwaguma, E. B.
AU - Lutwama, J. J.
AU - Kram, T. M.
AU - Karabatsos, N.
AU - Cropp, B. C.
AU - Miller, B. R.
JO - Virology (New York)
JF - Virology (New York)
Y1 - 1998///
VL - 252
IS - 1
SP - 258
EP - 268
SN - 0042-6822
AD - Lanciotti, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA.
N1 - Accession Number: 19990503369. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology
KW - arboviruses
KW - characterization
KW - epidemics
KW - genetics
KW - human diseases
KW - Uganda
KW - Alphavirus
KW - man
KW - o'nyong-nyong virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Alphavirus
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - arthropod-borne viruses
KW - o'nyong-nyong fever
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990503369&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Chemokine receptors and genetic variability. Another leap in HIV research.
AU - O'Brien, T. R.
AU - Goedert, J. J.
T2 - JAMA, Journal of the American Medical Association
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1998///
VL - 279
IS - 4
SP - 317
EP - 318
SN - 0098-7484
AD - O'Brien, T. R.: Viral Epidemiology Branch, National Cancer Institute, US Public Health Service, US Department of Health and Human Services, EPN 434, 6130 Executive Blvd., National Institutes of Health, North Bethesda, MD 20852, USA.
N1 - Accession Number: 19982008867. Publication Type: Editorial. Language: English. Number of References: 25 ref. Registry Number: 63231-63-0.
N2 - A brief overview is given of advances in HIV-1 and chemokine receptor research, from the discovery of the effect of the chemokines, RANTES, macrophage inflammatory protein-1 alpha (MIP-1α) and MIP-1β, on macrophage-tropic HIV strains in 1995 to the most recent research on genetic determinants of disease prognosis, such as the effect of CCR5Δ32 deletion reported in the same issue by M. Misrahi et al. (JAMA (1998), 279, 277-280) and also CCR2-64I. It is anticipated that the insights into the role of chemokine receptors in HIV-1 infection will enable new therapeutic approaches.
KW - acquired immune deficiency syndrome
KW - alleles
KW - chemokines
KW - children
KW - cytokines
KW - disease course
KW - genetic variation
KW - human diseases
KW - human immunodeficiency viruses
KW - maternal transmission
KW - mortality
KW - pathogenesis
KW - protection
KW - receptors
KW - research
KW - RNA
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - death rate
KW - disease progression
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - mother to child transmission
KW - ribonucleic acid
KW - studies
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008867&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Causes of declining life expectancy in Russia.
AU - Notzon, F. C.
AU - Komarov, Y. M.
AU - Ermakov, S. P.
AU - Sempos, C. T.
AU - Marks, J. S.
AU - Sempos, E. V.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1998///
VL - 279
IS - 10
SP - 793
EP - 800
SN - 0098-7484
AD - Notzon, F. C.: National Center for Health Statistics, Centers for Disease Control and Prevention, US Department of Health and Human Services, Hyattsville, MD, USA.
N1 - Accession Number: 19982004754. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Public Health
N2 - The contribution of selected causes of death to the dramatic decline in life expectancy in Russia which has occurred since the breakup of the Soviet Union in 1990 was assessed. Life-table methods were used to calculate life expectancy by year and a partitioning method was used to assess the contribution of specific causes of death and age groups to the overall decline in life expectancy. US data is presented for comparative purposes. Age-adjusted mortality in Russia rose by almost 33% during 1990-94. During that period, life expectancy for Russian men and women declined dramatically from 63.8 and 74.4 years to 57.7 and 71.2 years, respectively, while US life expectancy increased for both men and women from 71.8 and 78.8 years to 72.4 and 79.0 years, respectively. More than 75% of the decline in life expectancy was due to increased mortality rates for ages 25-64 years. Overall, cardiovascular diseases (heart disease and stroke) and injuries accounted for 65% of the decline in life expectancy while infectious diseases, including pneumonia and influenza, accounted for 5.8%, chronic liver diseases and cirrhosis for 2.4%, other alcohol-related causes for 9.6% and cancer for 0.7%. Increases in cardiovascular mortality accounted for 41.6% of the decline in life expectancy for women and 33.4% for men, while increases in mortality from injuries (eg. falls, occupational injuries, motor vehicle crashes, suicides and homicides) accounted for 32.8% of the decline in life expectancy for men and 21.8% for women. It is concluded that many factors have contributed to the striking decline in life expectancy, including economic and social instability, high rates of tobacco and alcohol consumption, poor nutrition, depression and deterioration of the health care system.
KW - alcohol intake
KW - cardiovascular diseases
KW - chronic course
KW - cirrhosis
KW - death
KW - economics
KW - health care
KW - human diseases
KW - infectious diseases
KW - influenza
KW - influenza viruses
KW - life expectancy
KW - liver
KW - liver diseases
KW - men
KW - mortality
KW - neoplasms
KW - nutrition
KW - pneumonia
KW - populations
KW - statistics
KW - tobacco
KW - trauma
KW - women
KW - Russia
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - alcohol consumption
KW - cancers
KW - communicable diseases
KW - death rate
KW - flu
KW - Influenzavirus
KW - liver cirrhosis
KW - Russian Federation
KW - traumas
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Services (UU350)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982004754&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cost-effectiveness analysis of a rotavirus immunization program for the United States.
AU - Tucker, A. W.
AU - Haddix, A. C.
AU - Bresee, J. S.
AU - Holman, R. C.
AU - Parashar, U. D.
AU - Glass, R. I.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1998///
VL - 279
IS - 17
SP - 1371
EP - 1376
SN - 0098-7484
AD - Tucker, A. W.: Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Rd NE, Mailstop G04, Atlanta, GA 30333, USA.
N1 - Accession Number: 19982008985. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - To estimate the economic impact of a national rotavirus immunization programme in the USA a decision tree was used which included estimates of disease burden, costs, vaccine coverage, efficacy and price, obtained from published and unpublished sources. The proposed vaccine would be administered to infants at ages 2, 4 and 6 months as part of the routine schedule of childhood immunizations. It was estimated that a routine, universal rotavirus immunization programme would prevent 1.08 million cases of diarrhoea, avoiding 34 000 hospitalizations, 95 000 emergency department visits and 227 000 physician visits in the first 5 years of life. At US$20 per dose, the programme would cost US$289 million and realize a net loss of US$107 million to the health care system (US$103 per case prevented). The programme would provide a net saving of US$296 million to society. Threshold analysis identified a break-even price per dose of US$9 for the health care system and US$51 for the societal perspective. Greater disease burden and greater vaccine efficacy and lower vaccine price increased cost-effectiveness. It is concluded that a US rotavirus immunization programme would be cost-effective from the perspectives of society and the health care system, although the cost of the immunization programme would not be fully offset by the reduction in health care cost of rotavirus diarrhoea unless the price fell to $9 per dose.
KW - children
KW - cost benefit analysis
KW - costs
KW - diarrhoea
KW - disease prevention
KW - human diseases
KW - immunization
KW - immunization programmes
KW - infants
KW - vaccination
KW - viral diseases
KW - USA
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - diarrhea
KW - immune sensitization
KW - immunization programs
KW - scouring
KW - United States of America
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982008985&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contamination of botanical dietary supplements by Digitalis lanata.
AU - Slifman, N. R.
AU - Obermeyer, W. R.
AU - Aloi, B. D.
AU - Musser, S. M.
AU - Correll, W. A.
AU - Cichowicz, S. M.
AU - Betz, J. M.
AU - Love, L. A.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 1998///
VL - 339
IS - 12
SP - 806
EP - 811
SN - 0028-4793
AD - Slifman, N. R.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C., USA.
N1 - Accession Number: 19980311720. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - Two case reports of women who had taken herbal drugs as part of an 'internal cleansing programme' and who had subsequently developed nausea, vomiting and heart problems (irregular heartbeats, shortness of breath, palpitations, chest pressure) are presented. Investigations indicated that both patients had ingested a plantain [Plantago] product which had been contaminated with Digitalis lanata.
KW - adverse effects
KW - case reports
KW - contamination
KW - herbal drugs
KW - USA
KW - Digitalis lanata
KW - man
KW - Plantago
KW - Digitalis
KW - Scrophulariaceae
KW - Scrophulariales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Plantaginaceae
KW - Plantaginales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - herbal medicines
KW - United States of America
KW - Plant Science (General) (FF000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19980311720&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance and clinical effectiveness of co-trimoxazole versus amoxycillin for pneumonia among children in Pakistan: randomised controlled trial.
AU - Straus, W. L.
AU - Qazi, S. A.
AU - Kundi, Z.
AU - Nomani, N. K.
AU - Schwartz, B.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 1998///
VL - 352
IS - 9124
SP - 270
EP - 274
SN - 0140-6736
AD - Straus, W. L.: Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, USA.
N1 - Accession Number: 19982013524. Publication Type: Journal Article. Corporate Author: Pakistan Co-trimoxazole Study Group Language: English. Number of References: 24 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 8064-90-2. Subject Subsets: Tropical Diseases
N2 - The effectiveness of co-trimoxazole was compared with that of amoxicillin in pneumonia therapy, and the clinical impact of co-trimoxazole resistance was assessed. 595 children, aged 2-59 months, with non-severe or severe pneumonia (WHO criteria) diagnosed in the outpatient wards of two urban Pakistan hospitals were recruited. Patients were randomly assigned on a 2:1 basis co-trimoxazole (n=398) or amoxicillin (n=197) in standard WHO doses and dosing schedules, and were monitored in study wards. The primary outcome was inpatient therapy failure (clinical criteria) or clinical evidence of pneumonia at outpatient follow-up examination. There were 92 (23%) therapy failures in the co-trimoxazole group and 30 (15%) in the amoxicillin group (P=0.03)-26 (13%) versus 12 (12%) among children with non-severe pneumonia (P=0.856) and 66 (33%) versus 18 (18%) among those with severe pneumonia (P=0.009). For patients with severe pneumonia, age under 1 year (P=0.056) and positive chest radiographs (P=0.005) also predicted therapy failure. There was no significant association between antimicrobial minimum inhibitory concentration and outcome among bacteraemic children treated with co-trimoxazole. It is concluded that co-trimoxazole provided effective therapy in non-severe pneumonia. For severe, life-threatening pneumonia, however, co-trimoxazole is less likely than amoxicillin to be effective.
KW - amoxicillin
KW - bacterial diseases
KW - children
KW - clinical aspects
KW - co-trimoxazole
KW - drug resistance
KW - drug therapy
KW - follow up
KW - human diseases
KW - pneumonia
KW - regimens
KW - Pakistan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - amoxycillin
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982013524&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of immunoassays for biomonitoring of herbicide metabolites in urine.
AU - Mastin, J. P.
AU - Striley, C. A. F.
AU - Biagini, R. E.
AU - Hines, C. J.
AU - Hull, R. D.
AU - MacKenzie, B. A.
AU - Robertson, S. K.
A2 - Emon, J. M. van
A2 - Gerlach, C. L.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 1998///
VL - 376
IS - 1
SP - 119
EP - 124
SN - 0003-2670
AD - Mastin, J. P.: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Sciences, 4676 Columbia Parkway, Mail Stop C-26, Cincinnati, OH 45223, USA.
N1 - Accession Number: 19992301373. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 8 ref. Registry Number: 1912-24-9, 51218-45-2.
N2 - Commercially available groundwater immunoassays (RaPID Assay®) were evaluated to determine their potential value for measuring herbicides or their metabolites in urine. Preliminary investigations of matrix effects and cross-reactivities indicated potential usefulness for the atrazine kit, but not the metolachlor kit, as a urinary biomonitoring tool.
KW - atrazine
KW - herbicides
KW - immunoassay
KW - metabolites
KW - methodology
KW - metolachlor
KW - monitoring
KW - urine
KW - urine analysis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - methods
KW - surveillance systems
KW - weedicides
KW - weedkillers
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992301373&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotoxicity in workers exposed to methyl bromide.
AU - Calvert, G. M.
AU - Talaska, G.
AU - Mueller, C. A.
AU - Ammenheuser, M. M.
AU - Au, W. W.
AU - Fajen, J. M.
AU - Fleming, L. E.
AU - Briggle, T.
AU - Ward, E.
JO - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
Y1 - 1998///
VL - 417
IS - 2/3
SP - 115
EP - 128
AD - Calvert, G. M.: Division of Surveillance, Hazard, Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-21, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19991106402. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 74-83-9. Subject Subsets: Agricultural Entomology
N2 - Blood and oropharyngeal cells of 32 methyl bromide-exposed fumigation workers were collected. Micronuclei were measured in lymphocytes and oropharyngeal cells, and hypoxanthine-guanine phosphoribosyl transferase gene (hprt) mutations were measured in lymphocytes. Among current non-smokers, the mean hprt variant frequency was 4.49 × 10-6 for workers and 2.96 × 10-6 for non-exposed controls. This difference was more pronounced among workers with 4 h or more of recent methyl bromide exposure; the geometric mean for these workers was 6.56 × 10-6. The mean oropharyngeal cell micronuclei value was 2.00 in workers and 1.31 in controls. The results were similar with workers with 4 h or more of recent methyl bromide exposure. No consistent differences between workers and controls were observed for frequencies of kinetochore-negative or -positive lymphocyte micronuclei. The study was limited by a sample size sufficient only for detecting relatively large differences, the absence of a reliable method to measure the intensity of workplace methyl bromide exposures, and relatively infrequent methyl bromide exposure; the median length of exposure to methyl bromide during the 2 weeks preceding the survey was 4 h. The results provide some evidence that methyl bromide exposure may be associated with genotoxic effects in lymphocytes and oropharyngeal cells.
KW - agricultural entomology
KW - fumigants
KW - genotoxicity
KW - lymphocytes
KW - methyl bromide
KW - mutations
KW - nontarget effects
KW - occupational hazards
KW - pesticides
KW - toxicology
KW - transferases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bromomethane
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991106402&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of trichlormethiazide in bovine milk by high-performance liquid chromatography.
AU - Shaikh, B.
AU - Rummel, N.
JO - Journal of Chromatography, B. Biomedical Sciences and Applications
JF - Journal of Chromatography, B. Biomedical Sciences and Applications
Y1 - 1998///
VL - 709
IS - 1
SP - 137
EP - 143
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-4347
AD - Shaikh, B.: Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043093586. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - A liquid chromatographic procedure was developed and validated for the quantitative determination of trichlormethiazide (TCMTZ) in bovine milk. Whole milk was defatted by initial centrifugation at 4°C. The resulting skim milk was treated with lead acetate and acetonitrile, vortex mixed, and centrifuged. The acetonitrile from the supernatant was back extracted in ethyl acetate. The organic solvent mixture which contained TCMTZ was further treated with sodium tungstate, vortex mixed, and centrifuged. The top organic layer was removed and evaporated to dryness; the resulting residue was reconstituted in the mobile phase, and the final extract was analyzed by high-performance liquid chromatography (HPLC). The HPLC conditions employed included a polymer column, a mobile phase consisting of 30% acetonitrile or 30% acetonitrile-tetrahydrofuran (2:1, v/v) in a phosphate buffer (pH 3), and a UV detection at 225 nm. The average recoveries of TCMTZ from milk fortified at 7, 14, 35, 70, and 140 ppb were 88, 93, 117, 110, and 99%, respectively, with corresponding C.V. values of 7, 18, 11, 9, and 21%. The method was validated by assaying milk obtained from a cow dosed with Naquasone. TCMTZ concentration was detected only in the 8 h post dose milk samples and was determined to be 6 ppb.
KW - drug residues
KW - HPLC
KW - milk
KW - quantitative analysis
KW - skim milk
KW - high performance liquid chromatography
KW - naquasone
KW - trichlormethiazide
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043093586&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of multiple tetracycline residues in milk and oxytetracycline in shrimp by liquid chromatography-particle beam mass spectrometry.
AU - Carson, M. C.
AU - Ngoh, M. A.
AU - Hadley, S. W.
JO - Journal of Chromatography, B. Biomedical Sciences and Applications
JF - Journal of Chromatography, B. Biomedical Sciences and Applications
Y1 - 1998///
VL - 712
IS - 1/2
SP - 113
EP - 128
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-4347
AD - Carson, M. C.: US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043085090. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 79-57-2, 60-54-8, 64-75-5. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science
N2 - A confirmation procedure is described for detection of residues of six tetracyclines in bovine milk, and oxytetracycline in shrimp. Residues are extracted from milk or shrimp tissue using metal chelate affinity chromatography. The extracts are desalted, further concentrated using polymeric solid-phase extraction, and chromatographed on a polymeric reversed-phase column. Analysis is by methane negative ion chemical ionization on a quadrupole mass spectrometer using a particle beam interface. Data are acquired in partial scan mode, monitoring from m/z 378 to m/z 480. The procedure was validated with control milk and shrimp, fortified milk (30 ng/ml) and shrimp (100 ng/g), and milk and tissue from animals treated with the drugs.
KW - analytical methods
KW - antibiotic residues
KW - dairy cattle
KW - drug residues
KW - food contamination
KW - liquid chromatography
KW - mass spectrometry
KW - milk
KW - milk testing
KW - oxytetracycline
KW - safety testing
KW - shrimp culture
KW - shrimps
KW - techniques
KW - tetracycline
KW - cattle
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - achromycin
KW - analytical techniques
KW - food contaminants
KW - shellfish farming
KW - shellfish ranching
KW - shrimp farming
KW - shrimp ranching
KW - terramycin
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Dairy Animals (LL110)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Milk and Dairy Produce (QQ010)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043085090&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of cloud-point extraction-reversed-phase high-performance liquid chromatography: a preliminary study of the extraction and quantification of vitamins A and E in human serum and whole blood.
AU - Sirimanne, S. R.
AU - Patterson, D. G., Jr.
AU - Ma, L.
AU - Justice, J. B., Jr.
JO - Journal of Chromatography, B. Biomedical Sciences and Applications
JF - Journal of Chromatography, B. Biomedical Sciences and Applications
Y1 - 1998///
VL - 716
IS - 1/2
SP - 129
EP - 137
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-4347
AD - Sirimanne, S. R.: Division of Environmental Health Laboratory Sciences, National Centers for Environmental Health, Centers for Disease Control and Prevention (CDC), Public Health Service, US Department of Health and Human Services, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20043093587. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Methods available for quantification of vitamins A and E in serum or blood requires preconcentration and clean-up by liquid-liquid extraction, evaporation of the extract, and reconstitution of the extract in a solvent of choice before analysis. This process not only involves the use of toxic organic solvents but also requires a long sample preparation time. The lipids and other non-polar coextractants often require additional steps for sample clean-up and evaporation, which may cause sample losses. The use of cloud-point extraction eliminates most of these sample clean-up problems. We recently demonstrated that cloud-point extraction (CPE) can be used for extraction and quantification of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo-p-dioxins (PCDDs) from human serum. We now demonstrate how CPE can be used with human serum and blood, at volumes as low as 50 µl, and report a methodology for extracting and quantifying two clinically important vitamins, (A and E) from human serum and blood. Vitamins A and E were extracted from human serum and blood by using Genapol X-80 as the cloud-point extractant under salting out conditions. Serum and blood samples were diluted in organic-free water to get sufficiently large sample volumes for CPE. The surfactant-rich phases were separated by centrifugation, and the samples were analyzed by HPLC-UV after deleterious coextractants were removed by precipitating them with acetonitrile. The recoveries of spiked vitamins A and E were found to be 85.6±0.4% and 82.6±5.2%, respectively. The average concentration of vitamins A and E in a serum pool after correction for recoveries were found to be 43.4±1.8 µg/dl (1.5±0.1 µmol/l) and 564.3±65.3 µg/dl (13.1±1.5 µmol/l), respectively. Vitamin A and E concentrations in whole blood were found to be 26.3±0.4 µg/dl (0.92±0.01 µmol/l) and 457.5±15.6 µg/dl (10.6±0.4 µmol/l), respectively. These values are comparable with those obtained by the reference method used at the Centers for Disease Control and Prevention. The success of the preliminary study will lead to a comprehensive validation of this method for vitamins A and E in serum and blood.
KW - analytical methods
KW - blood serum
KW - extraction
KW - HPLC
KW - retinol
KW - reverse phase liquid chromatography
KW - techniques
KW - vitamin E
KW - analytical techniques
KW - axerophthol
KW - high performance liquid chromatography
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Physiology of Human Nutrition (VV120)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043093587&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sample preparation and high-resolution separation of mycotoxins possessing carboxyl groups.
AU - Wilkes, J. G.
AU - Sutherland, J. B.
T3 - Special issue: Separations of acidic (carboxyl-possessing) compounds
JO - Journal of Chromatography, B. Biomedical Sciences and Applications
JF - Journal of Chromatography, B. Biomedical Sciences and Applications
Y1 - 1998///
VL - 717
IS - 1/2
SP - 135
EP - 156
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-4347
AD - Wilkes, J. G.: National Center for Toxicological Research, Jeffersen, AR 72079, USA.
N1 - Accession Number: 20043093669. Publication Type: Journal Article. Note: Special issue: Separations of acidic (carboxyl-possessing) compounds Language: English. Number of References: 107 ref. Registry Number: 518-75-2, 303-47-9. Subject Subsets: Medical & Veterinary Mycology
N2 - The chromatographic analysis of carboxyl-containing mycotoxins, such as fumonisin B1, ochratoxin A, and citrinin, presents a continual challenge. Toxins must first be extracted from foods or tissues and then cleaned up before chromatographic separation and detection. Liquid-liquid extraction efficiencies for some carboxylic mycotoxins are marginal for spiked samples and uncertain for incurred residues. Immunoaffinity columns may be useful for concentrating mycotoxins from samples before chromatography. In almost every case, more than one analytical method must be used to confirm the identification of the mycotoxin. The fumonisins are especially troublesome to analyze because they are relatively insoluble in organic solvents, they are not separated easily by gas chromatography, and they do not respond to the usual absorbance or fluorescence detectors used in liquid chromatography. Fluorescence derivatization and electrospray liquid chromatography-mass spectrometry have now made it possible to detect trace levels of mycotoxins. The purity of mycotoxin standards for toxicological studies can be determined by liquid chromatography with either an evaporative light scattering detector or electrospray mass spectrometer. New developments in capillary electrophoresis, nonporous microsphere liquid chromatography, and detection methods for low-volatility compounds show promise for improving the analysis of mycotoxins in the future.
KW - analytical methods
KW - chromatography
KW - citrinin
KW - fumonisins
KW - mycotoxins
KW - ochratoxin A
KW - ochratoxins
KW - reviews
KW - separation
KW - analytical techniques
KW - fumonisin B1
KW - fungal toxins
KW - separating
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043093669&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of spectinomycin in milk using ion-pair solid-phase extraction and liquid chromatography-electrospray ion trap mass spectrometry.
AU - Carson, M. C.
AU - Heller, D. N.
JO - Journal of Chromatography, B. Biomedical Sciences and Applications
JF - Journal of Chromatography, B. Biomedical Sciences and Applications
Y1 - 1998///
VL - 718
IS - 1
SP - 95
EP - 102
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-4347
AD - Carson, M. C.: Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043086504. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 21736-83-4, 22189-32-8, 1695-77-8. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science
N2 - A confirmation procedure is described for residues of spectinomycin in bovine milk. Spectinomycin is extracted from raw milk using ion-pair reversed-phase solid-phase extraction. The extracts are ion-pair chromatographed on a polymeric reversed-phase column and analysed on a quadrupole ion trap mass spectrometer equipped with an electrospray interface. MS-MS data are acquired in the scan mode of product ions deriving from m/z 333, the protonated molecular ion. The estimated limit of confirmation is between 0.05 and 0.1 µg/ml. The procedure was validated with control milk, fortified milk (0.1-5.0 µg/ml), and milk from cows dosed with spectinomycin.
KW - antibiotic residues
KW - cows
KW - drug residues
KW - extraction
KW - food contamination
KW - liquid chromatography
KW - mass spectrometry
KW - milk
KW - spectinomycin
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043086504&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of counterfeit and relabeled infant formulas by high-pH anion-exchange chromatography-pulsed amperometric detection for the determination of sugar profiles.
AU - Kaine, L. A.
AU - Wolnik, K. A.
A2 - Dasgupta, P. K.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 1998///
VL - 804
IS - 1/2
SP - 279
EP - 287
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Kaine, L. A.: US Food and Drug Administration, 1141 Central Parkway, Cincinnati, OH 45202, USA.
N1 - Accession Number: 20013142488. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 7 ref. Registry Number: 50-99-7, 62-42-3, 8006-91-5, 9050-36-6, 69-79-4, 57-50-1. Subject Subsets: Soyabeans; Sugar Industry; Dairy Science
N2 - A high pH anion-exchange separation with pulsed amperometric detection has been developed to profile the water soluble carbohydrate content of powdered infant formula. Glucose, lactose, sucrose, maltose, and maltodextrin were determined in six milk-based, five soy-based, and two protein hydrolysate brands of infant formula. The carbohydrate profiles are used along with the results of other analytical techniques to make best estimates of the identity of an unknown powder.
KW - anion exchange
KW - chromatography
KW - glucose
KW - infant formulae
KW - lactose
KW - maltodextrins
KW - maltose
KW - pH
KW - protein hydrolysates
KW - sucrose
KW - dextri-maltose
KW - dextrose
KW - hydrogen ion concentration
KW - hydrolysed proteins
KW - infant formula
KW - infant formulas
KW - milk sugar
KW - potential of hydrogen
KW - saccharose
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013142488&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chromatographic methods of analysis of antibiotics in milk.
AU - Schenck, F. J.
AU - Callery, P. S.
T3 - Special issue. Chromatography of antibiotics
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 1998///
VL - 812
IS - 1/2
SP - 99
EP - 109
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Schenck, F. J.: Food and Drug Administration, Baltimore District Laboratory, 900 Madison Avenue, Baltimore, MD 21201, USA.
N1 - Accession Number: 20013142466. Publication Type: Journal Article. Note: Special issue. Chromatography of antibiotics Language: English. Number of References: 91 ref. Registry Number: 60-54-8, 64-75-5. Subject Subsets: Dairy Science; Veterinary Science; Veterinary Science
N2 - The widespread use of antibiotics in dairy cattle management may result in the presence of antibiotic residues in milk. While rapid screening tests are commonly used to detect the presence of antibiotics in milk, more accurate chromatographic methods are required by government regulatory agencies to identify and confirm the identity and quantity of antibiotic present. This paper reviews recent developments in the chromatographic determination of antibiotic residues in milk.
KW - aminoglycoside antibiotics
KW - antibiotic residues
KW - drug residues
KW - liquid chromatography
KW - macrolide antibiotics
KW - milk
KW - tetracycline
KW - achromycin
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013142466&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of fumonisin B1 on lipid peroxidation in membranes.
AU - Yin JunJie
AU - Smith, M. J.
AU - Eppley, R. M.
AU - Page, S. W.
AU - Sphon, J. A.
JO - Biochimica et Biophysica Acta, Biomembranes
JF - Biochimica et Biophysica Acta, Biomembranes
Y1 - 1998///
VL - 1371
IS - 1
SP - 134
EP - 142
SN - 0005-2736
AD - Yin JunJie: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19991201057. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Electron spin resonance (ESR)1 spin-label oximetry and spin trapping techniques were used to study the effect of fumonisin B1 (FB1) on lipid peroxidation in egg yolk phosphatidylcholine (EYPC) bilayers. In a study of the interaction between FB1 and lipid bilayers the results showed that fumonisin disturbs the ordering of membranes, enhances oxygen transport in membranes and also increases membrane permeability. In this model system, lipid peroxidations were initiated by extended incubation of the liposomes or by inducing Fe2+ ions, UV illumination of H2O2 or ultrasound irradiation. As an indication of the rates of lipid oxidation in EYPC, the consumption of molecular oxygen was studied by monitoring the oxygen concentration in the aqueous phases of the liposomes. Lipid-derived free radicals generated during the oxidation process were measured by a spin trapping method. The incorporation of FB1 in the test samples made the membranes highly susceptible to oxidation. It is concluded that fumonisins appear to increase the rate of oxidation, promote the free radical intermediate production and accelerate the chain reactions associated with lipid peroxidation. The disruption of membrane structure, the enlargement of the relative oxygen diffusion-concentration products, as well as the enhancement effects on membrane permeability, therefore provide additional insights into potential mechanisms by which the fumonisins could enhance oxidative stress and cell damage.
KW - egg yolk
KW - fumonisins
KW - lipid peroxidation
KW - membranes
KW - toxicity
KW - yolk
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991201057&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Measles, mumps, and rubella - vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP).
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1998///
IS - RR-8
SP - 1
EP - 57
SN - 0149-2195
AD - US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19982011894. Publication Type: Miscellaneous. Language: English. Number of References: 230 ref. Subject Subsets: Public Health
N2 - These recommendations supersede recommendations published in 1989 and 1990. They summarize the goals and current strategies for measles, rubella and congenital rubella syndrome (CRS) elimination and for mumps reduction in the USA. The following topics are discussed: background information on measles, mumps and rubella; vaccine preparations and usage; documentation of immunity; routine vaccination; special considerations for vaccination; adverse events after MMR vaccination and their reporting; vaccine injury compensation; precautions and contraindications; surveillance and outbreak control.
KW - congenital infection
KW - guidelines
KW - human diseases
KW - immunization
KW - measles
KW - mumps
KW - rubella
KW - vaccines
KW - viral diseases
KW - USA
KW - man
KW - measles virus
KW - mumps virus
KW - rubella virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Rubulavirus
KW - Rubivirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - German measles
KW - immune sensitization
KW - prenatal infection
KW - recommendations
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19982011894&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intervention tools for farmers - safe and productive work practices in a safer work environment.
AU - Scharf, T.
AU - Kidd, P.
AU - Cole, H.
AU - Bean, T.
AU - Chapman, L.
AU - Donham, K.
AU - Baker, D.
A2 - Murphy, D. J.
A2 - Aherin, R.
A2 - Duncan, J. R.
A2 - Field, W. E.
A2 - Gunderson, P. D.
A2 - Popendorf, W.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 1998///
IS - SPEC/ISS 1
SP - 193
EP - 203
AD - Scharf, T.: National Institute of Occupational Safety and Health, (NIOSH), C-24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 19991800865. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 20 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology
N2 - Recent interventions in agricultural safety and health in the USA have developed a more comprehensive and contextual approach to farm safety behaviours. These are broad, general approaches to safe work practices that complement the task-focused safety training and engineering interventions of many farm safety programmes. Some common features of these more recent interventions are: (1) the interventions require the active participation of the farmers and farm workers, for whom the interventions are intended; (2) farm economics and productivity are recognized as powerful determinants in shaping the structure and organization of the enterprise; (3) safe work practices and safety-related improvements in the work environment are shown to promote the productivity and economic viability of the farm; and (4) participation from community members, including extension agents, 4-H, FFA, educators, equipment dealers, insurance agents, bankers, local media, and others can be the key to making such interventions successful - both in the early phases, and over the long term. This article describes a breakout session that was held at the Agricultural Health and Safety Conference sponsored by the National Institute for Occupational Safety and Health, 15-17 July 1997, in Morgantown, West Virginia. The panel was convened to address the approaches to interventions outlined above. These approaches, brief highlights of six presentations illustrating these approaches to interventions, comments from three discuss ants, and feedback from the audience are summarized in this article.
KW - farm workers
KW - farmers
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Labour and Employment (EE900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - 1997 National Institute of Occupational Safety and Health (NIOSH) agricultural safety and health conference, Morgantown, West Virginia, USA, July 1997.
A2 - Murphy, D. J.
A2 - Aherin, R.
A2 - Duncan, J. R.
A2 - Field, W. E.
A2 - Gunderson, P. D.
A2 - Popendorf, W.
T2 - Journal of Agricultural Safety and Health
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 1998///
IS - SPEC/ISS 1
SP - 212
EP - 212
AD - National Institute for Occupational Safety and Health, Atlanta, GA, USA.
N1 - Accession Number: 19982403277. Publication Type: Conference proceedings. Language: English. Subject Subsets: Agricultural Engineering; Public Health
N2 - This conference proceedings is divided into 2 sections with 10 papers on hazard and injury surveillance and 10 papers on interventions and strategies. The hazard and injury surveillance articles range from detailed studies of state and national (USA) hazard and injury data, to exploring new methods of obtaining data from difficult-to-reach populations of exposed workers. The interventions and strategies articles convey a richness and diversity in methods aimed at reducing unintended injury to farmers, farmworkers, and farm families.
KW - accident prevention
KW - accidents
KW - health
KW - safety
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Ergonomics and Safety (NN100) (Discontinued March 2000)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The issue of antimicrobial use in poultry.
AU - Sundlof, S.
T2 - 33rd National Meeting on Poultry Health & Processing, Sheraton Ocean City, Ocean City, Maryland, USA, October 14-16, 1998.
JO - 33rd National Meeting on Poultry Health & Processing, Sheraton Ocean City, Ocean City, Maryland, USA, October 14-16, 1998.
JF - 33rd National Meeting on Poultry Health & Processing, Sheraton Ocean City, Ocean City, Maryland, USA, October 14-16, 1998.
Y1 - 1998///
SP - 38
EP - 45
CY - Georgetown; USA
PB - Delmarva Poultry Industry Inc
AD - Sundlof, S.: Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992211119. Publication Type: Conference paper. Language: English. Subject Subsets: Veterinary Science; Poultry
KW - antibiotics
KW - drug resistance
KW - drug therapy
KW - food hygiene
KW - foodborne diseases
KW - legislation
KW - meat hygiene
KW - poultry
KW - zoonoses
KW - USA
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - chickens
KW - domesticated birds
KW - United States of America
KW - zoonotic infections
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The global pandemic of dengue/dengue hemorrhagic fever: current status and prospects for the future.
AU - Gubler, D. J.
A2 - Goh, K. T.
T2 - Dengue in Singapore.
Y1 - 1998///
CY - Singapore; Singapore
PB - Institute of Environmental Epidemiology
SN - 9810401647
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990502493. Publication Type: Book chapter. Language: English. Number of References: 38 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This paper briefly reviews the changing epidemiology of dengue, discusses some of the factors responsible for the recent resurgence, and reviews the current options for reversing the trend of this emergent disease.
KW - arboviruses
KW - clinical aspects
KW - dengue
KW - dengue haemorrhagic fever
KW - disease prevention
KW - disease vectors
KW - epidemiology
KW - geographical distribution
KW - incidence
KW - maps
KW - natural history
KW - reviews
KW - Aedes aegypti
KW - Culicidae
KW - dengue virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - arthropod-borne viruses
KW - clinical picture
KW - dengue hemorrhagic fever
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502493&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Dengue control in Singapore.
AU - Reiter, P.
A2 - Goh, K. T.
T2 - Dengue in Singapore.
Y1 - 1998///
CY - Singapore; Singapore
PB - Institute of Environmental Epidemiology
SN - 9810401647
AD - Reiter, P.: Entomology Unit, Dengue Branch, Division of Vector-borne Infectious Diseases, Centers for Disease Control & Prevention, US Public Health Service, 2, Calle Casia, San Juan, 00921-3200 Puerto Rico.
N1 - Accession Number: 19990502507. Publication Type: Book chapter. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The dengue control programme of the Singapore Government has been in operation since the mid-1960s. Indices of vector breeding sites an other measurements help to monitor disease prevalence. There is strong evidence that the control programme has had a significant impact on dengue transmission, and seroprevalence studies confirm that transmission has been low for the past 15 years. The control measures were predominantly those of environmental management with the identification and removal of Aedes larval habitats. There was a clear association of housing types with disease incidence, slum housing being strongly associated with increased disease incidence. Education, community action and thermal fogging all contributed to Aedes control. However, since 1986 there has been a progressive increase in the number of reported cases of dengue fever and dengue haemorrhagic fever/dengue shock syndrome. Incidence is low in terms of the total population, and extensive epidemic transmission has not occurred. Moreover, at least 1 in 20 reported cases is an imported infection, and it is probable that many indigenous cases are directly linked to these imported cases.
KW - arboviruses
KW - breeding places
KW - chemical control
KW - community action
KW - control
KW - dengue
KW - dengue haemorrhagic fever
KW - dengue shock syndrome
KW - disease prevalence
KW - education
KW - environmental control
KW - environmental management
KW - fogging
KW - human diseases
KW - insecticides
KW - public health
KW - vector control
KW - Singapore
KW - Aedes aegypti
KW - Aedes albopictus
KW - Culicidae
KW - dengue virus
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - ASEAN Countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Threshold Countries
KW - arthropod-borne viruses
KW - Asian tiger mosquito
KW - breeding habitats
KW - breeding sites
KW - dengue hemorrhagic fever
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Environmental Pest Management (HH200)
KW - Pesticides and Drugs (General) (HH400)
KW - Participation and Self Help (UU470) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Analysis of trans fatty acids.
AU - McDonald, R. E.
AU - Mossoba, M. M.
A2 - Akoh, C. C.
A2 - Min, D. B.
T2 - Food lipids: chemistry, nutrition, and biotechnology.
Y1 - 1998///
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824799852
AD - McDonald, R. E.: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Agro, Illinois, USA.
N1 - Accession Number: 19981415460. Publication Type: Book chapter. Language: English. Number of References: 132 ref. Subject Subsets: Human Nutrition
N2 - This chapter discusses the newest developments in analytical methods to determine the concentration and confirm the identity of individual trans and cis fatty acids isomers, including infrared, Raman, nuclear magnetic resonance spectroscopy, gas chromatography, HPLC, supercritical fluid chromatography and mass spectrometry.
KW - analytical methods
KW - composition
KW - fatty acids
KW - foods
KW - gas chromatography
KW - HPLC
KW - infrared spectroscopy
KW - isomers
KW - mass spectrometry
KW - milk products
KW - nuclear magnetic resonance spectroscopy
KW - plant oils
KW - trans fatty acids
KW - analytical techniques
KW - dairy products
KW - high performance liquid chromatography
KW - vegetable oils
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Meat Produce (QQ030)
KW - Milk and Dairy Produce (QQ010)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Residue and exposure levels of dietary endocrine modulators and disruptors.
AU - Bolger, P. M.
A2 - Dunaif, G. E.
A2 - Olin, S. S.
A2 - Scimeca, J. A.
A2 - Thomas, J. A.
T2 - Human diet and endocrine modulation: estrogenic and androgenic effects.
Y1 - 1998///
CY - Washington; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 1578810256
AD - Bolger, P. M.: Contaminants Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, USA.
N1 - Accession Number: 20001408655. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - This paper examines those chemicals that act as endocrine modulators or disruptors. The level of these compounds in the food supply is monitored by such agencies as the US Food and Drug Administration who conduct an annual Total Diet Study and are also jointly responsible for the monitoring of pesticides in the food chain. These issues are discussed.
KW - diet
KW - food additives
KW - food contamination
KW - foods
KW - government organizations
KW - hormones
KW - monitoring
KW - pesticide residues
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - surveillance systems
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Crop Produce (QQ050)
KW - Sugar and Sugar Products (QQ020)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Perspectives on plant toxicology and public health.
AU - Betz, J. M.
AU - Page, S. W.
A2 - Garland, T.
A2 - Barr, A. C.
T2 - Toxic plants and other natural toxicants
Y1 - 1998///
CY - Wallingford; UK
PB - CAB International
SN - 0851992633
AD - Betz, J. M.: US FDA, Center for Food Safety and Applied Nutrition, Division of Natural Products, Washington, DC 20204, USA.
N1 - Accession Number: 20073012470. Publication Type: Book chapter. Language: English. Number of References: 36 ref. Subject Subsets: Weeds; Aromatic & Medicinal Plants; Postharvest Research
N2 - This chapter describes human health problems caused by botanicals, as well as the circumstances under which intoxication occurred: misidentification, misuse (abuse, and incorrect or inappropriate use), deliberate adulteration and inherent toxicity. Improved quality assurance and consumer education could significantly decrease the adverse health effects associated with botanical products (particularly with the dietary supplements).
KW - adulteration
KW - adverse effects
KW - consumer education
KW - diets
KW - herbal drugs
KW - medicinal plants
KW - misidentification
KW - natural products
KW - poisoning
KW - poisonous plants
KW - public health
KW - quality controls
KW - safety
KW - supplements
KW - toxicity
KW - toxicology
KW - plants
KW - eukaryotes
KW - adverse reactions
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - quality assurance
KW - toxic plants
KW - toxicosis
KW - Education and Training (CC100)
KW - Weeds and Noxious Plants (FF500)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Toxinology (VV820) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Public health and risk assessment.
AU - Wagstaff, D. J.
AU - Bolger, P. M.
AU - Carrington, C. D.
A2 - Garland, T.
A2 - Barr, A. C.
T2 - Toxic plants and other natural toxicants
Y1 - 1998///
CY - Wallingford; UK
PB - CAB International
SN - 0851992633
AD - Wagstaff, D. J.: US FDA, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20073012469. Publication Type: Book chapter. Language: English. Number of References: 2 ref. Registry Number: 149-29-1. Subject Subsets: Weeds; Aromatic & Medicinal Plants; Medical & Veterinary Mycology; Horticultural Science; Postharvest Research
N2 - This chapter focuses on the risk assessment of plants and plant products used as food or drugs. The steps in the risk assessment process are discussed: safety concerns, hazard identifications, safety, exposure, and dose response assessments, risk characterization and decision or action. A safety assessment for patulin (a substance in rotting apples), which is an example in the steps of risk assessment, is presented. Tabulated data on human patulin exposure from apple juice and maximum patulin concentration to achieve a tolerable daily intake of 0.43 µg kg-1 day-1 are provided, as well as tabulated summary of dose response of rats given patulin by gastric intubation 3 times a week for 109 weeks.
KW - apple juice
KW - apples
KW - exposure
KW - food safety
KW - hazards
KW - herbal drugs
KW - patulin
KW - plant products
KW - public health
KW - risk assessment
KW - Malus
KW - plants
KW - rats
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - crop products
KW - herbal medicines
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infection-stimulated or perinatally initiated idiotypic interactions can direct differential morbidity and mortality in schistosomiasis.
AU - Colley, D. G.
AU - Montesano, M. A.
AU - Freeman, G. L., Jr.
AU - Secor, W. E.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 1999///
VL - 1
IS - 7
SP - 517
EP - 524
AD - Colley, D. G.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19990805770. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Helminthology
N2 - Male CBA/J mice were infected with 45 cercariae of a Puerto Rican strain of Schistosoma mansoni. Serum was collected 6-20 weeks pi and assayed for cross-reactive immunoregulatory idiotypes (CRI). The 20-week clinical form (moderate splenomegaly syndrome (MSS) or hypersplenomegaly syndrome (HSS)) was recorded for each animal and compared against CRI levels. CRIs were expressed early in the infections in all mice that eventually developed MSS, but were never expressed in any mice that died or became HSS. This differential CRI expression and parallel morbidity/mortality was influenced dramatically by exposing naive mice to CRIs at birth, 8 weeks before exposure to S. mansoni.
KW - antibodies
KW - clinical aspects
KW - experimental infections
KW - helminths
KW - idiotypes
KW - immune response
KW - immunology
KW - immunopathology
KW - laboratory animals
KW - morbidity
KW - mortality
KW - parasites
KW - schistosomiasis
KW - splenomegaly
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - clinical picture
KW - cross-reactive immunoregulatory idiotypes
KW - death rate
KW - hypersplenomegaly
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - parasitic worms
KW - schistosomosis
KW - Strigeida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of latex porosity: a review of virus barrier tests.
AU - Lytle, C. D.
AU - Routson, L. B.
JO - Journal of Rubber Research
JF - Journal of Rubber Research
Y1 - 1999///
VL - 2
IS - 1
SP - 29
EP - 39
AD - Lytle, C. D.: Center for Devices and Radiological Health, Food and Drug Administration, 9200 Corporate Boulevard, Rockville, Maryland 20852, USA.
N1 - Accession Number: 19992008277. Publication Type: Journal Article. Language: English. Number of References: 39 ref.
N2 - Evidence regarding whether latex films as found in condoms and medical gloves are effective barriers to virus passage is reviewed, together with new data from additional tests. The primary focus was to determine whether latex films are porous as opposed to having occasional defects. The published and new evidence from studies using viruses are consistent only with the presence of occasional defects, and are not consistent with porosity sufficient to allow virus passage. However, quality control of manufactured products based on acceptable quality levels using standardised tests does not guarantee that every sample is perfect. The risk of a specific product is related to the defect rate, the use situation, and the disease of interest, in particular the quantity of virus-carrying fluid needed to constitute an 'infectious dose.' The possibility of latex film hydration leading to porosity to virus passage was also found to be unlikely and not supported by data.
KW - condoms
KW - disease transmission
KW - gloves
KW - human diseases
KW - latex
KW - porosity
KW - quality controls
KW - viral diseases
KW - man
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - quality assurance
KW - viral infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maintenance and sustained use of insecticide-treated bednets and curtains three years after a controlled trial in western Kenya.
AU - Kachur, S. P.
AU - Phillips-Howard, P. A.
AU - Odhacha, A. M.
AU - Ruebush, T. K.
AU - Oloo, A. J.
AU - Nahlen, B. L.
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
Y1 - 1999///
VL - 4
IS - 11
SP - 728
EP - 735
AD - Kachur, S. P.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 20000503737. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 52645-53-1. Subject Subsets: Medical & Veterinary Entomology
N2 - A follow up study was instigated in 1997 at the site of a small-scale insecticide-treated materials (ITM) (permethrin) intervention trial in western Kenya, 3 years after the project ended, to assess how local attitudes and practices had changed. Qualitative and quantitative methods, including 16 focus group discussions and a household survey (n=60), were employed to assess use, maintenance, retreatment and perceptions of ITM and the insecticide in former study communities. Families that had been issued bednets were more likely to have kept and maintained them and valued bednets more highly than those who had been issued curtains. While most households retained their original bednets, none had treated them with insecticide since the intervention trial was completed 3 years earlier. Most of those who had been issued bednets repaired them, but none acquired new or replacement nets. In contrast, households that had been issued insecticide-treated curtains often removed them. Three (15%) of the households issued curtains had purchased one or more bednets since the study ended. In households where bednets had been issued, children 10 years of age and younger were a third as likely to sleep under a net as were adults (relative risk (RR)=0.32; 95% confidence interval=0.19, 0.53).
KW - attitudes
KW - bed nets
KW - chemical control
KW - curtains
KW - families
KW - impregnated fabrics
KW - maintenance
KW - mosquito nets
KW - permethrin
KW - pyrethroid insecticides
KW - surveys
KW - villages
KW - Kenya
KW - Culicidae
KW - man
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - mosquitoes
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Community Participation and Development (UU450) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000503737&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Campylobacter jejuni - an emerging foodborne pathogen.
AU - Altekruse, S. F.
AU - Stern, N. J.
AU - Fields, P. I.
AU - Swerdlow, D. L.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 1999///
VL - 5
IS - 1
SP - 28
EP - 35
AD - Altekruse, S. F.: US Food and Drug Administration, Blacksburg, VA, USA.
N1 - Accession Number: 19992003779. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Public Health
N2 - Campylobacter jejuni, the most commonly reported bacterial cause of foodborne infection in the USA, is reviewed. Adding to the human and economic costs are chronic sequelae associated with C. jejuni infection - Guillain-Barré syndrome and reactive arthritis. In addition, an increasing proportion of human infections caused by C. jejuni are resistant to antimicrobial therapy. Mishandling of raw poultry and consumption of undercooked poultry are the major risk factors for human campylobacteriosis. Efforts to prevent human illness are needed throughout each link in the food chain.
KW - arthritis
KW - campylobacteriosis
KW - drug resistance
KW - foodborne diseases
KW - Guillain-Barre syndrome
KW - human diseases
KW - poultry
KW - reviews
KW - USA
KW - Campylobacter jejuni
KW - man
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - domesticated birds
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992003779&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identifying work-related fatalities in the agricultural production sector using two national occupational fatality surveillance systems, 1990-1995.
AU - Hard, D. L.
AU - Myers, J. R.
AU - Snyder, K. A.
AU - Casini, V. J.
AU - Morton, L. L.
AU - Cianfrocco, R.
AU - Fields, J.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 1999///
VL - 5
IS - 2
SP - 155
EP - 169
AD - Hard, D. L.: National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Rd. MS/P-1133, Morgantown, WV 26505, USA.
N1 - Accession Number: 20001807445. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology
N2 - A descriptive analysis is presented of agricultural production fatalities for 1990-95. Two USA national occupational fatality data sources were used to calculate agricultural production fatality rates: the National Traumatic Occupational Fatalities (NTOF) and the Census of Fatal Occupational Injuries (CFOI). Employment estimates for calculating fatality rates came from the Current Population Survey (CPS). The majority of agricultural production worker decedents were white male farmers. The leading sources of injury were farm tractors, followed by trucks and harvesting equipment. Older agricultural workers (65+ years of age) were at high risk for death, with the most likely fatal event being the overturning of a tractor in a non-highway environment. Black workers in the agricultural production industry, and the occupation of black farmers in particular, were identified as having high fatal injury rates by race. Young Hispanic workers also exhibited a high fatality rate. Farm tractors were a leading source of injury resulting in death for males and females; however, there were gender differences in other types of fatalities. Females, while accounting for a small percentage of the total fatalities in agriculture production, had a higher proportion of deaths due to animals than did males, and also had a higher proportion of deaths due to being caught in running equipment than males. The two national occupational fatality surveillance systems, while showing differences in overall numbers, generally identified similar patterns of death for agricultural production workers. Finally, no clear downward trend for agricultural production fatalities was found, which is contrary to trends seen in the general worker population over the same time period.
KW - agricultural production
KW - employment
KW - farmers
KW - mortality
KW - occupational health
KW - tractors
KW - trends
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - jobs
KW - United States of America
KW - Agricultural Economics (EE110)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001807445&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioterrorism: how prepared are we?
AU - Shalala, D. E.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 1999///
VL - 5
IS - 4
SP - 492
EP - 493
AD - Shalala, D. E.: U.S. Secretary of Health and Human Services, USA.
N1 - Accession Number: 19992011886. Publication Type: Journal Article. Language: English.
KW - biological warfare
KW - terrorism
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011886&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vaccines, pharmaceutical products, and bioterrorism: challenges for the U.S. Food and Drug Administration.
AU - Zoon, K. C.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 1999///
VL - 5
IS - 4
SP - 534
EP - 536
AD - Zoon, K. C.: U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19992011878. Publication Type: Journal Article. Language: English. Number of References: 3 ref.
KW - biological warfare
KW - drugs
KW - human diseases
KW - terrorism
KW - vaccines
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011878&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of Bartonella henselae and Bartonella clarridgeiae in an urban Indonesian cat population.
AU - Marston, E. L.
AU - Finkel, B.
AU - Regnery, R. L.
AU - Winoto, I. L.
AU - Graham, R. R.
AU - Wignal, S.
AU - Simanjuntak, G.
AU - Olson, J. G.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 1999///
VL - 6
IS - 1
SP - 41
EP - 44
SN - 1071-412X
AD - Marston, E. L.: Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19990502677. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - The authors studied evidence of B. henselae and B. clarridgeiae infection in 54 cats living in Jakarta, Indonesia, in 1995-96. By using an indirect immunofluorescence assay, IgG antibody to B. henselae was found in 40 of 74 cats (54%). The blood of 14 feral cats was cultured on rabbit blood agar plates for 28 days. Bartonella-like colonies were identified as B. henselae or B. clarridgeiae by using restriction fragment length polymorphism analysis and direct sequencing of the PCR amplicons. Of the cats sampled in the study, 6 of 14 (43%; all feral) were culture positive for B. henselae; 3 of 14 (21%; 2 feral and 1 pet) culture positive for B. clarridgeiae. This is the first report that documents B. henselae and B. clarridgeiae infections in Indonesian cats.
KW - antibodies
KW - cat scratch disease
KW - feral cats
KW - IgG
KW - immunoglobulins
KW - serological surveys
KW - urban areas
KW - zoonoses
KW - Indonesia
KW - Java
KW - Bartonella
KW - Bartonella clarridgeiae
KW - Bartonella henselae
KW - cats
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bartonella
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Indonesia
KW - bacterium
KW - gamma-globulins
KW - immune globulins
KW - Jawa
KW - seroepidemiology
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections.
AU - Jason, J.
AU - Archibald, L.
AU - McDonald, L. C.
AU - Hart, W. M.
AU - Rheanppumikankit, S.
AU - Tansuphwaswadikul, S.
AU - Byrd, M. G.
AU - Larned, J.
AU - Han, A.
AU - Green, T. A.
AU - Jarvis, W. R.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 1999///
VL - 6
IS - 1
SP - 73
EP - 78
SN - 1071-412X
AD - Jason, J.: Immunology Branch, Division of AIDS, Sexually Transmitted Diseases, and Tuberculosis Laboratory Research, National Center for Infectious Diseases Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 19992005021. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9008-11-1, 308079-78-9. Subject Subsets: Tropical Diseases
N2 - In Thailand, 53 febrile, hospitalized adults were enrolled during February-April 1997 in a study of the immune correlates of bloodstream infections (BSI). On site, blood cells were stimulated ex vivo. Cell-surface antigens and 8 intracellular cytokines were subsequently analysed using flow cytometry to determine associations with mortality and the organism causing the BSI. By logistic regression analysis, the percentage of CD3+ CD16/56+ cells making tumour necrosis factor alpha (TNF-α) (P=0.033) and the percentage of CD3- CD16/56+ cells (NK) (P=0.032) were related to HIV positivity. Lymph node enlargement with HIV infection and the percentage of CD3+ CD16/56+ making TNF-α were predictive of death. A lower percentage of CD3+ CD8+ lymphocytes making interleukin-8 (IL-8) (P=0.005), fewer monocytes expressing CD14 (P=0.009) and the percentage of CD3+ CD8+ cells producing gamma interferon (P=0.011) were associated with blood culture positivity and the causative organism. For every one point decrease in the percentage of CD3+ CD8+ cells making IL-8, the likelihood of a positive culture increased 23%; for every one point decrease in the percentage of monocytes expressing CD14, the likelihood of a positive culture increased by 5%. Only a few immune cell types and 3 of their related cytokines were significantly associated with HIV disease outcome or the BSI organism. These cell types did not include CD3+ CD8- cells (a surrogate for CD4+ cells), nor did they involve cytokines associated with a type I to type II cytokine shift, which might occur with advancing HIV infection. It is concluded that CD8+ and CD16/56+ lymphocytes play significant roles in HIV and type I infections.
KW - blood
KW - cytokines
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - immunocompromised hosts
KW - infections
KW - interferon
KW - interleukins
KW - lymphocytes
KW - monocytes
KW - opportunistic infections
KW - septicaemia
KW - tumour necrosis factor
KW - Thailand
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - blood poisoning
KW - cachectin
KW - cachexin
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunity reactions
KW - immunological reactions
KW - septicemia
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatal work-related injuries in the agricultural production and services sectors among youth in the United States, 1992-96.
AU - Castillo, D. N.
AU - Adekoya, N.
AU - Myers, J. R.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 1999///
VL - 6
IS - 3
SP - 27
EP - 41
SN - 1059-924X
AD - Castillo, D. N.: Surveillance and Field Investigations Branch, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20002015205. Publication Type: Journal Article. Language: English. Number of References: 42 ref.
N2 - We used data from the U.S. Bureau of Labor Statistics' Census of Fatal Occupational Injuries to describe fatal agricultural work injuries among youth less than 20 years of age during 1992-96. There were 188 deaths, 23% of which were tractor-related. Eighty-three deaths were reported among individuals engaged in family businesses. The fatality rate for 15- to 19-year-olds was 12.2 deaths per 100,000 full-time equivalents. Youth fatality rates were comparable to those of adult workers up until the age group of 45-54 years. Non-regulatory approaches to preventing injuries, especially in family businesses, are important given the current form of U.S. child labour laws.
KW - adolescents
KW - agriculture
KW - child labour
KW - children
KW - farm workers
KW - farmers
KW - farming
KW - mortality
KW - occupational health
KW - tractors
KW - trauma
KW - youth
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - child labor
KW - death rate
KW - teenagers
KW - traumas
KW - Occupational Health and Safety (VV900)
KW - Agriculture (General) (AA000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002015205&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.
AU - Melnyk, S.
AU - Pogribna, M.
AU - Pogribny, I.
AU - Hine, R. J.
AU - James, S. J.
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
Y1 - 1999///
VL - 10
IS - 8
SP - 490
EP - 497
SN - 0955-2863
AD - Melnyk, S.: Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR, USA.
N1 - Accession Number: 19991414566. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 56-88-2, 52-90-4, 56-89-3, 70-18-8, 6027-13-0, 63-68-3. Subject Subsets: Human Nutrition
N2 - A method was developed for determining a complete profile of the most common monothiols and disulfides present in plasma or tissue extracts. The method utilizes reversed phase ion-pairing HPLC coupled with coulometric electrochemical detection to simultaneously quantify free oxidized and reduced aminothiols or total aminothiols after chemical reduction. It is extremely sensitive, with limits of detection in the 5 fmol/ml range for monothiols and 50 fmol/ml for dithiols. The interassay and intraassay coefficients of variation for total and free aminothiols ranged from 1.2 to 5.8% and the mean recoveries for total and plasma aminothiols ranged from 97.1 and 102.8%. The aminothiols are quantified directly, without derivatization and include methionine, homocysteine, homocysteine, cystathionine, cysteine, cystine, cysteinylglycine, and oxidized and reduced glutathione. It is concluded that because a complete aminothiol profile of metabolites in both the remethylation (anabolic) and transulfuration (catabolic) pathways of homocysteine metabolism can be determined simultaneously, this new method should be useful in determining the metabolic aetiology of homocysteinaemia and in designing appropriate nutritional intervention strategies. Basic research applications of this method should lead to an increased understanding of the metabolic pathology of aminothiol imbalance.
KW - analytical methods
KW - chromatography
KW - cystathionine
KW - cysteine
KW - cystine
KW - glutathione
KW - homocysteine
KW - HPLC
KW - metabolites
KW - methionine
KW - plasma
KW - sulfur amino acids
KW - techniques
KW - thiols
KW - tissues
KW - analytical techniques
KW - high performance liquid chromatography
KW - mercaptans
KW - sulphur amino acids
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414566&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - US HIV and AIDS cases reported through June 1999.
T2 - HIV/AIDS Surveillance Report
JO - HIV/AIDS Surveillance Report
JF - HIV/AIDS Surveillance Report
Y1 - 1999///
VL - 11
IS - 1
SP - 1
EP - 42
CY - Atlanta; USA
PB - US Department of Health and Human Services, Centres for Disease Control, Epidemiology Program Office
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, GA 30333, USA.
N1 - Accession Number: 20002006581. Publication Type: Miscellaneous. Language: English. Subject Subsets: Public Health
N2 - This report includes data on human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) cases reported in the USA through June 1999, AIDS incidence and deaths in 1998, and AIDS prevalence as of December 1998. The incidence of AIDS decreased by 18% between 1996 and 1997 and by 11% from 1997 to 1998. AIDS deaths decreased by 42% from 1996 to 1997 and 20% from 1997 to 1998. The number of persons living with AIDS continued to increase, with 269 777 persons living with AIDS at the end of 1997 and 297 137 by the end of 1998 (an increase of 10%). A total of 47 083 AIDS cases were reported from July 1998-June 1999, compared to 54 140 and 64 597 cases reported in July 1997-June 1998 and July 1996-June 1997, respectively. Women accounted for 10 841 (23%) of adult AIDS cases reported. Blacks and Hispanics accounted for 80% of cases among women and 61% of cases among men. Women accounted for 32% of adult cases of HIV infection reported during July 1998-June 1999. Blacks and Hispanics accounted for 77% of HIV cases among women and 58% among men. 15% of reported HIV cases were in persons aged 13-24 years, and women accounted for 49% of cases in this age group.
KW - acquired immune deficiency syndrome
KW - epidemiology
KW - human diseases
KW - human immunodeficiency viruses
KW - trends
KW - USA
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of arsenic and selenium in food using a microwave digestion - dry ash preparation and flow injection hydride generation atomic absorption spectrometry.
AU - Mindak, W. R.
AU - Dolan, S. P.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 1999///
VL - 12
IS - 2
SP - 111
EP - 122
SN - 0889-1575
AD - Mindak, W. R.: Elemental Research Branch (HFS-338), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 19991414165. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7440-38-2, 7782-49-2. Subject Subsets: Human Nutrition; Dairy Science
N2 - A method is described for the determination of arsenic and selenium contents in food samples including meat, milk products, eggs, vegetables, beverages and processed foods by atomic absorption spectrometry. Arsenic and selenium fortification recoveries ranged from 96 to 105% and 88 to 107% respectively. Limits of detection for 1 g of sample were 0.01 mg/kg for arsenic and 0.02 mg/kg for selenium.
KW - absorption
KW - analytical methods
KW - arsenic
KW - beverages
KW - concentrated milk
KW - digestion
KW - eggs
KW - food
KW - meat
KW - milk products
KW - selenium
KW - vegetables
KW - analytical techniques
KW - atomic absorption spectrometry
KW - dairy products
KW - drinks
KW - processed foods
KW - vegetable crops
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414165&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - V3-loop and nef gene sequences of HIV-1 isolates from a hemophiliac cohort with long-term non-progressive infection.
AU - Vallejo, A.
AU - Mas, A.
AU - Heredia, A.
AU - Altisent, C.
AU - Lorenzo, I.
AU - Soriano, V.
AU - Hewlett, I. K.
T2 - AIDS
JO - AIDS
JF - AIDS
Y1 - 1999///
VL - 13
IS - 4
SP - 532
EP - 534
SN - 0269-9370
AD - Vallejo, A.: Laboratory of Molecular Virology, US Food and Drug Administration, 1401 Rockville Pike, Bethesda, MD 20852-1448, USA.
N1 - Accession Number: 19992008574. Publication Type: Correspondence. Language: English. Number of References: 15 ref.
KW - acquired immune deficiency syndrome
KW - genes
KW - genetics
KW - genotypes
KW - haemophilia
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - hemophilia
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008574&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The use of plasma HIV RNA as a study endpoint in efficacy trials of antiretroviral drugs.
AU - Murray, J. S.
AU - Elashoff, M. R.
AU - Iacono-Connors, L. C.
AU - Cvetkovich, T. A.
AU - Struble, K. A.
JO - AIDS
JF - AIDS
Y1 - 1999///
VL - 13
IS - 7
SP - 797
EP - 804
SN - 0269-9370
AD - Murray, J. S.: Division of Antiviral Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 19992008416. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 63231-63-0.
N2 - Data collected from antiretroviral efficacy trials were analysed to explore relationships between clinical progression and the magnitude, nadir and duration of HIV RNA reductions. The proportion of patients suppressing HIV RNA below assay quantification, time to maximal virological response, and loss of virological response in relation to pretreatment characteristics were also analysed. Analyses were conducted using data from individual antiretroviral efficacy trials or groups of trials that studied similar types of drug regimens and used similar HIV RNA assays. Treatment regimens were pooled for most analyses. Clinical progression was defined as the occurrence of an AIDS-defining event (essentially Centers of Disease Control criteria) or death. Treatment-induced reductions in HIV RNA approximating total assay variability of about 0.5 log10 copies/ml were associated with decreases in the risk of clinical progression. Larger and more sustained reductions in HIV RNA were directly associated with lower risks for disease progression. Lower initial HIV RNA reductions were associated with more durable HIV RNA suppression. For antiretroviral efficacy studies, plasma HIV RNA is a suitable study endpoint that is likely to predict a decreased risk for AIDS progression and death. It is concluded that because greater and more sustained reductions in HIV RNA appear to confer greater reductions in clinical risk, maintaining maximal suppression of plasma HIV RNA, particularly below the limits of assay quantification, appears to be a rigorous benchmark for assessing the efficacy of antiretroviral regimens.
KW - antiviral agents
KW - blood
KW - clinical trials
KW - combination therapy
KW - disease course
KW - drug therapy
KW - efficacy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - multiple drug therapy
KW - RNA
KW - techniques
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - combination drug therapy
KW - combined modality therapy
KW - disease progression
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - multimodal treatment
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992008416&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sustained plasma TNF-α and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans.
AU - Lawn, S. D.
AU - Shattock, R. J.
AU - Acheampong, J. W.
AU - Lal, R. B.
AU - Folks, T. M.
AU - Griffin, G. E.
AU - Butera, S. T.
JO - AIDS
JF - AIDS
Y1 - 1999///
VL - 13
IS - 16
SP - 2231
EP - 2237
SN - 0269-9370
AD - Lawn, S. D.: HIV and Retrovirology Branch, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20002004897. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-41-4, 308079-78-9. Subject Subsets: Tropical Diseases
N2 - A study was conducted [date not given] to determine the impact of treatment of tuberculosis on plasma HIV-1 load in African subjects and to correlate viral load with response to treatment and changes in immune activation. Clinical and microbiological responses, immune activation parameters and plasma HIV-1 load were determined in 20 patients with pulmonary tuberculosis and HIV-1 coinfection in Ghana, West Africa, during the first 3 months of anti-tuberculosis treatment. Plasma HIV-1 load and markers of immune activation were determined by commercially available assays. Human leukocyte antigen (HLA)-DR incorporation into the HIV-1 envelope was measured by using an immunomagnetic capture technique. Treatment of tuberculosis resulted in significant improvements in weight and haemoglobin, a high sputum smear conversion rate and marked reductions in mean plasma tumour necrosis factor (TNF) receptor-1, interleukin-6 and C-reactive protein. Furthermore, incorporation of host HLA-DR into the HIV-1 envelope decreased; this also suggested a reduction in immune activation of the cells supporting viral replication. However, of importance with regard to AIDS pathogenesis, neither mean plasma TNF-α nor HIV-1 load decreased significantly. It is concluded that the failure of HIV-1 plasma load to decline significantly during the initial months of anti-tuberculosis treatment is associated with high, sustained systemic levels of TNF-α. The dissociation between the sustained levels of plasma TNF-α and the major reductions in other, diverse immune activation parameters may represent dysregulation of cytokine production in these African patients.
KW - acquired immune deficiency syndrome
KW - C-reactive protein
KW - clinical aspects
KW - cytokines
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - immunocompromised hosts
KW - interleukin 6
KW - opportunistic infections
KW - tuberculosis
KW - tumour necrosis factor
KW - viral load
KW - Ghana
KW - Human immunodeficiency virus 1
KW - man
KW - Mycobacterium tuberculosis
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - AIDS
KW - bacterium
KW - cachectin
KW - cachexin
KW - chemotherapy
KW - clinical picture
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002004897&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of nonhuman primates in the development of an AIDS vaccine.
AU - Nathanson, N.
AU - Hirsch, V. M.
AU - Mathieson, B. J.
JO - AIDS
JF - AIDS
Y1 - 1999///
VL - 13
SP - S113
EP - S120
SN - 0269-9370
AD - Nathanson, N.: Office of AIDS Research, National Institutes of Health, US Department of Health and Human Services, Room 4C02, Building 31, 9000 Rockville Pike, Bethesda, MD 20892-2340, USA.
N1 - Accession Number: 19992011743. Publication Type: Journal Article. Language: English. Number of References: 74 ref.
KW - acquired immune deficiency syndrome
KW - animal models
KW - disease models
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - reviews
KW - vaccine development
KW - vaccines
KW - man
KW - Primates
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011743&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion.
AU - Tolleson, W. H.
AU - Couch, L. H.
AU - Melchior, W. B., Jr.
AU - Jenkins, G. R.
AU - Muskhelishvili, M.
AU - Muskhelishvili, L.
AU - McGarrity, L. J.
AU - Domon, O.
AU - Morris, S. M.
AU - Howard, P. C.
JO - International Journal of Oncology
JF - International Journal of Oncology
Y1 - 1999///
VL - 14
IS - 5
SP - 833
EP - 843
SN - 1019-6439
AD - Tolleson, W. H.: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991202284. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The role of sphingolipid changes in fumonisin B1-stimulated apoptosis was examined in cultured human keratinocytes. Sphinganine accumulated rapidly, sphingosine levels remained unchanged and ceramides decreased during fumonisin B1 exposure. Increased DNA fragmentation, decreased viability and apoptotic morphology were observed in cells exposed to fumonisin B1, sphinganine or N-acetylsphingosine. Co-exposure to N-acetylsphingosine or β-chloroalanine, which blocks sphinganine accumulation, partially protected cells from fumonisin B1-induced apoptosis. It is concluded that there are 3 sphingolipid-dependent mechanisms for inducing apoptosis: accumulation of excess ceramide, accumulation of excess sphinganine and depletion of ceramide or complex sphingolipids derived from ceramide.
KW - apoptosis
KW - epidermis
KW - fumonisins
KW - keratinocytes
KW - sphingolipids
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991202284&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Chemical food borne hazards and their control.
A2 - Tollefson, L.
T2 - Veterinary Clinics of North America, Food Animal Practice
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 0
EP - 213
SN - 0749-0720
AD - Office of Surveillance and Compliance, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19992207365. Publication Type: Miscellaneous. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - The papers in this issue include: The human food safety evaluation of new animal drugs; Monitoring adverse reactions to veterinary drugs; Health implications of residues of veterinary drugs and chemicals in animal tissues; Federal surveillance of veterinary drugs and chemical residues; The national milk safety programme and drug residues in milk; The food animal residue avoidance databank; Regulatory approaches for controlling pesticide residues in food animals; PBBs, PCBs and dioxins in food animals; Mycotoxicosis in food producing animals; Center for veterinary medicine's perspective on the beef hormone case; International harmonization issues; Producer quality assurance programmes. There are 29 contributors and there is an index.
KW - beef
KW - drug residues
KW - food hygiene
KW - food safety
KW - hormones
KW - legislation
KW - livestock
KW - meat
KW - meat hygiene
KW - milk
KW - mycotoxicoses
KW - pesticide residues
KW - veterinary products
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - mycotoxin poisoning
KW - United States of America
KW - Meat Produce (QQ030)
KW - Meat Producing Animals (LL120)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207365&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The human food safety evaluation of new animal drugs.
AU - Friedlander, L. G.
AU - Brynes, S. D.
AU - Fernández, A. H.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 1
EP - 11
SN - 0749-0720
AD - Friedlander, L. G.: Division of Human Food Safety, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855-2764, USA.
N1 - Accession Number: 19992207353. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Veterinary Science
KW - animal husbandry
KW - drugs
KW - food additives
KW - food contamination
KW - food hygiene
KW - food safety
KW - livestock
KW - livestock farming
KW - livestock feeding
KW - risk factors
KW - toxicology
KW - Canada
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - livestock husbandry
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207353&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health implications of residues of veterinary drugs and chemicals in animal tissues.
AU - Paige, J. C.
AU - Tollefson, L.
AU - Miller, M. A.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 31
EP - 43
SN - 0749-0720
AD - Paige, J. C.: US Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, HFV-218, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207355. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Veterinary Science
KW - allergies
KW - antiinfective agents
KW - beta-blockers
KW - carcinogenesis
KW - carcinogens
KW - drug residues
KW - food hygiene
KW - food safety
KW - intestinal microorganisms
KW - meat animals
KW - pharmacology
KW - poisoning
KW - public health
KW - teratogens
KW - toxicity
KW - veterinary products
KW - adrenergic beta receptor blockaders
KW - animal health products
KW - antimicrobials
KW - gut flora
KW - intestinal micro-organisms
KW - toxicosis
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207355&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Federal surveillance of veterinary drugs and chemical residues (with recent data).
AU - Paige, J. C.
AU - Chaudry, M. H.
AU - Pell, F. M.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 45
EP - 61
SN - 0749-0720
AD - Paige, J. C.: Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, HFV-218, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207356. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Veterinary Science
KW - animal diseases
KW - drug residues
KW - food hygiene
KW - food safety
KW - meat animals
KW - public health
KW - veterinary products
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - United States of America
KW - Residues and Contamination of Animal Products (SS120) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207356&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The national milk safety program and drug residues in milk.
AU - Talley, M. R.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 63
EP - 73
SN - 0749-0720
AD - Talley, M. R.: US Food and Drug Administration, Center for Veterinary Medicine, HFV-216, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207357. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Veterinary Science; Dairy Science
N2 - Milk safety in the USA is discussed, with reference to the Food and Drug Administration and its role in regulating the industry.
KW - dairy industry
KW - drug residues
KW - legislation
KW - milk
KW - milk quality
KW - milk testing
KW - public health
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health programmes
KW - United States of America
KW - Dairy Animals (LL110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Residues and Contamination of Animal Products (SS120) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207357&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - PBBs, PCBs, and dioxins in food animals, their public health implications.
AU - Headrick, M. L.
AU - Hollinger, K.
AU - Lovell, R. A.
AU - Matheson, J. C.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 109
EP - 131
SN - 0749-0720
AD - Headrick, M. L.: US Food and Drug Administration, Center for Veterinary Medicine, HFV-218, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207360. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Veterinary Science; Animal Nutrition
KW - contamination
KW - control
KW - diagnosis
KW - dioxins
KW - epidemiology
KW - feeds
KW - food contamination
KW - food safety
KW - meat animals
KW - polybrominated biphenyls
KW - polychlorinated biphenyls
KW - prevention
KW - public health
KW - tolerance
KW - toxicology
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - food contaminants
KW - PCBs
KW - United States of America
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Residues and Contamination of Animal Products (SS120) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207360&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxicosis in food producing animals.
AU - Hollinger, K.
AU - Ekperigin, H. E.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 133
EP - 165
SN - 0749-0720
AD - Hollinger, K.: Division of Epidemiology and Surveillance, Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207361. Publication Type: Journal Article. Language: English. Number of References: 74 ref. Registry Number: 18172-33-3, 17924-92-4, 303-47-9. Subject Subsets: Veterinary Science; Pig Science; Medical & Veterinary Mycology
N2 - The toxic affects of aflatoxins, cyclopiazonic acid, fumonisins, ochratoxin A and zearalenone are discussed, with relation to pigs, cattle, poultry and sheep. Sources of infection, geographic distribution, conditions for toxin production, mechanisms of action, reduction of risks, disease prevention and control, public health impacts and human exposure and food animal clinical signs, are covered for each mycotoxin.
KW - aflatoxicosis
KW - aflatoxins
KW - clinical aspects
KW - cyclopiazonic acid
KW - disease control
KW - disease prevention
KW - food poisoning
KW - food safety
KW - fumonisins
KW - livestock
KW - mycotoxicoses
KW - mycotoxins
KW - ochratoxicosis
KW - ochratoxin A
KW - ochratoxins
KW - poultry
KW - public health
KW - risk factors
KW - toxins
KW - zearalenone
KW - cattle
KW - man
KW - pigs
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - aflatoxin poisoning
KW - clinical picture
KW - domesticated birds
KW - f-2 toxin
KW - fungal toxins
KW - hogs
KW - mycotoxin poisoning
KW - swine
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207361&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Center for veterinary medicine's perspective on the beef hormone case.
AU - Leighton, J. K.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 167
EP - 180
SN - 0749-0720
AD - Leighton, J. K.: Division of Oncologic Drug Products, Center for Drug Evaluation and Research, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19992207362. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Veterinary Science
KW - beef
KW - feed additives
KW - growth promoters
KW - hormones
KW - meat hygiene
KW - oestrus
KW - steroid hormones
KW - synchronization
KW - synthetic androgens
KW - synthetic hormones
KW - synthetic oestrogens
KW - synthetic progestogens
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrus
KW - growth stimulants
KW - synthetic estrogens
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Meat Producing Animals (LL120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207362&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - International harmonization issues.
AU - Thompson, S. R.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 181
EP - 195
SN - 0749-0720
AD - Thompson, S. R.: Veterinary Medical and International Affairs, Center for Veterinary Medicine, MPN2, HFV-3, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207363. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 9002-72-6. Subject Subsets: Veterinary Science
KW - drug residues
KW - international trade
KW - legislation
KW - meat
KW - somatotropin
KW - veterinary products
KW - animal health products
KW - growth hormone
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Meat Producing Animals (LL120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207363&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Producer quality assurance programs.
AU - Kla, J.
AU - Tollefson, L.
JO - Veterinary Clinics of North America, Food Animal Practice
JF - Veterinary Clinics of North America, Food Animal Practice
Y1 - 1999///
VL - 15
IS - 1
SP - 197
EP - 208
SN - 0749-0720
AD - Kla, J.: Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 19992207364. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Veterinary Science; Pig Science
KW - animal production
KW - beef
KW - cows
KW - dairy cows
KW - disease control
KW - drug residues
KW - meat hygiene
KW - milk
KW - pigmeat
KW - poultry meat
KW - veal
KW - veterinary products
KW - cattle
KW - pigs
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - animal health products
KW - hogs
KW - pork
KW - swine
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Producing Animals (LL120)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207364&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A historical review of the F-1 strain of Anopheles freeborni as a host and vector for studies of malaria.
AU - Collins, W. E.
AU - Jeffery, G. M.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1999///
VL - 15
IS - 2
SP - 117
EP - 127
SN - 8756-971X
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19990506454. Publication Type: Journal Article. Language: English. Number of References: 6 pp. of ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - A review was made of the use of a specific strain of A. freeborni from California, USA, (F-1), that has been used extensively in experimental investigations of malaria for >50 years. The F-1 strain of A. freeborni has been shown to be a suitable experimental host and vector for different species of Plasmodium that cause malaria in humans and nonhuman primates for biological, immunological and chemotherapeutic studies. Eleven species of Plasmodium fully completed sporogonic development; development of sporozoites within mature oocysts occurred in an additional 7 species. Transmission through A. freeborni from human to human, monkey to human, or monkey to monkey has been demonstrated for 9 species of Plasmodium.
KW - disease transmission
KW - disease vectors
KW - experimental infection
KW - infection
KW - laboratory animals
KW - malaria
KW - oocysts
KW - parasites
KW - reviews
KW - sporogony
KW - sporozoites
KW - vector competence
KW - Anopheles freeborni
KW - Culicidae
KW - Diptera
KW - man
KW - monkeys
KW - Plasmodium
KW - Plasmodium falciparum
KW - Plasmodium malariae
KW - Plasmodium ovale
KW - Plasmodium vivax
KW - Primates
KW - protozoa
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Plasmodium
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506454&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aedes albopictus in the United States: current status and prospects for further spread.
AU - Moore, C. G.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 1999///
VL - 15
IS - 2
SP - 221
EP - 227
SN - 8756-971X
AD - Moore, C. G.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990506525. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Since its initial discovery in the continental USA in 1985, A. albopictus, has spread rapidly throughout the eastern part of the country. Infestations of A. albopictus now have been reported to the Centers for Disease Control and Prevention from 919 counties in 26 states in the continental USA. This species is believed to be established in 911 counties in 25 states. Single individuals or small numbers of A. albopictus have been intercepted and destroyed in 3 additional states (California, New Mexico and Washington). Five states (Florida, Georgia, North Carolina, South Carolina and Tennessee) have reported infestations in all of their counties. The current reported distribution of A. albopictus was compared to ecoregions of the U.S. Environmental Protection Agency's Level III ecoregion map. Several areas are identified as probable candidates for extension of this species based on ecological characteristics of the landscape. In other areas, populations seem likely to become locally abundant in urban or suburban oases that do not reflect the native ecology of the region. The ability of A. albopictus to transmit a variety of pathogens of human and veterinary public health importance, coupled with its ability to colonize diverse ecological settings makes continued surveillance an important issue.
KW - geographical distribution
KW - introduced species
KW - reviews
KW - spread
KW - USA
KW - Aedes albopictus
KW - Culicidae
KW - Diptera
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Asian tiger mosquito
KW - exotic organisms
KW - exotic species
KW - introduced organisms
KW - mosquitoes
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Biological Resources (Animal) (PP710)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990506525&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thrombotic events associated with megestrol acetate in patients with AIDS cachexia.
AU - Koller, E.
AU - Gibert, C.
AU - Green, L.
AU - Mann, M.
AU - Bernstein, B.
JO - Nutrition
JF - Nutrition
Y1 - 1999///
VL - 15
IS - 4
SP - 294
EP - 298
AD - Koller, E.: Center for Drug Evaluation at the US Food and Drug Administration, Parklawn Building-Room 14 B04/HFD 510, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 19991408465. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
KW - acquired immune deficiency syndrome
KW - appetite
KW - body weight
KW - cachexia
KW - drug therapy
KW - emaciation
KW - human immunodeficiency viruses
KW - immunosuppression
KW - thrombosis
KW - wasting disease
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - blood clots
KW - chemotherapy
KW - human immunodeficiency virus
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991408465&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A multi-state survey of consumer food-handling and food-consumption practices.
AU - Altekruse, S. F.
AU - Yang, S.
AU - Timbo, B. B.
AU - Angulo, F. J.
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 1999///
VL - 16
IS - 3
SP - 216
EP - 221
SN - 0749-3797
AD - Altekruse, S. F.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Assessment and Support, Division of Market Studies, Epidemiology Branch (HFS-728), Washington, DC, USA.
N1 - Accession Number: 19991410093. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Human Nutrition
N2 - Surveillance for risky food-handling and food-consumption practices can be used to identify high-risk populations, develop educational efforts, and evaluate progress toward risk reduction. In 1995 and 1996, Behavioural Risk Factor Surveillance System interviews of 19 356 adults in 8 states (Colorado, Florida, Missouri, New York, and Tennessee, Indiana, New Jersey, and South Dakota) included questions related to food-handling and/or food-consumption practices. Risky food-handling and food-consumption practices were not uncommon. Overall, 19% of respondents did not adequately wash hands or cutting boards after contact with raw meat or chicken. During the previous year, 20% ate pink hamburgers, 50% ate undercooked eggs, 8% ate raw oysters, and 1% drank raw milk. Men were more likely to report risky practices than women. The prevalence of most risky behaviours increased with increasing socioeconomic status. It is concluded that targeted education efforts may reduce the frequency of these behaviours. Periodic surveillance can be used to assess effectiveness. In addition to consumer education, prevention efforts are needed throughout the food chain including on the farm, in processing, distribution, and at retail.
KW - consumption
KW - education
KW - food contamination
KW - food hygiene
KW - food safety
KW - foodborne diseases
KW - foods
KW - oysters
KW - socioeconomic status
KW - surveys
KW - USA
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410093&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary arsenic intakes in the United States: FDA Total Diet Study, September 1991-December 1996.
AU - Tao, S. S. H.
AU - Bolger, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 1999///
VL - 16
IS - 11
SP - 465
EP - 472
SN - 0265-203X
AD - Tao, S. S. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW Washington, DC 20204, USA.
N1 - Accession Number: 20001406434. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7440-38-2. Subject Subsets: Human Nutrition
N2 - The FDA has conducted the Total Dietary Study (TDS), a yearly market basket programme, since 1961. It is designed to monitor the levels of toxic chemical contaminants (pesticide residues, industrial and elemental contaminants) and essential nutrients in the US food supply. It also provides information on trends in dietary concentrations and exposures for the general population. Foods are collected from retail stores once a year from each of four geographic areas of the US and are analysed either after preparation/cooking or as ready-to-eat. The latest TDS (1991-1997) data show that arsenic (inorganic and organic, ≥ 0.03 ppm) was found in 63 (24%) of the 261-264 foods/mixed dishes analysed. The highest concentration was found in seafood, followed by rice/rice cereal, mushrooms, and poultry. Based on the United States Department of Agriculture's 1987-1988 Nationwide Food Consumption Survey, the estimated daily total arsenic average intakes, in µg/day, are: 2 for infants, 23 for toddlers, 20 for 6-year-old children, 13 for 10-year-old children, 15 for 14-16-year-old boys, 21 for 14-16-year-old girls, 57 for 25-30-year-old men, 28 for 25-30-year-old women, 47 for 40-45-year-old men, 37 for 40-45-year-old women, 92 for 60-65-year-old men, 72 for 60-65-year-old women, 69 for 70-year-old men, and 42 for 70-year-old women. Of the estimated total arsenic intakes for infants, 42% arise from seafood and 31% from rice/rice cereals. Of the estimated total arsenic intakes, seafood contributes 76-90% for children (2-10-year olds), 79-85% for 14-16-year olds, and 89-96% for adults (≥ 25-30-year olds); rice/rice cereals contributes 4-8% for children, 8% for 14-16-year olds, and 1-4% for adults (≥ 25-30-year olds).
KW - arsenic
KW - boys
KW - cereals
KW - children
KW - diet studies
KW - diets
KW - edible fungi
KW - food consumption
KW - food supply
KW - foods
KW - girls
KW - infants
KW - mushrooms
KW - nutrients
KW - pesticide residues
KW - pesticides
KW - poultry
KW - residues
KW - rice
KW - seafoods
KW - USA
KW - fungi
KW - man
KW - Oryza
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - domesticated birds
KW - paddy
KW - United States of America
KW - Food Policy, Food Security and Food Aid (EE500) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406434&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunomodulating effects of polysaccharides isolated from herbal products.
AU - Lee ChiJen
AU - Koizumi, K.
AU - Koizumi, M.
AU - Aburada, M.
JO - Journal of Traditional Medicines
JF - Journal of Traditional Medicines
Y1 - 1999///
VL - 16
IS - 5/6
SP - 175
EP - 182
AD - Lee ChiJen: Center for Biologics Evaluation and Research, Food and Drug Administration, 1185-5 Sasagi, Tsukuba city, 305-0043, Japan.
N1 - Accession Number: 20000309286. Publication Type: Journal Article. Language: English. Language of Summary: Japanese. Number of References: 33 ref. Registry Number: 308067-58-5, 9008-11-1, 102524-44-7, 85898-30-2, 207137-56-2, 308079-78-9. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - Polysaccharides (PSs) were isolated from Angelicae Radix [Angelica] and Hoelen [Macrohyporia extensa], and their immunomodulating effects were studied. Angelica PS consisted mainly of glucose, galactose, rhamnose, arabinose and galacturonic acid, whereas Hoelen PS contained galactose, glucose, mannose and galacturonic acid. The mice injected with Angelica or Hoelen PS, 0.2-1.0 mg/dose, i.p., followed by administration of pneumococcal type 9V PS-protein conjugate, 5 µg/dose, i.p., produced higher serum levels of 9V PS IgG and IgM antibodies than the non-treated control group. The mice treated with plant PS showed more rapid bacterial clearance from blood after challenge with virulent type 19F pneumococci. In addition, in mice immunized with type 9V glycoconjugate, treatment with plant PS induced TNF-α [tumour necrosis factor-α] to give a level 4.0- to 5.5-fold higher than that of the control group. In immunized mice treated with Hoelen PS, 2.3-fold higher INF-γ (interferon-γ) activity was induced. Moreover, in immunized mice treated with plant PS, the production of IL-2 (interleukin 2) was 1.5- to 3.9-fold higher, whereas IL-4 level was 4.6- to 6.4-fold higher as compared with the control group. These results indicate that one of the mechanisms regarding the stimulating effects of plant PSs is through enhancing the activities of cytokines and immune responses. Application of plant PSs to bacterial glycoconjugate vaccines could provide more effective protective immunity for the prevention of pneumococcal infection.
KW - antibodies
KW - cytokines
KW - IgG
KW - IgM
KW - immune response
KW - immune system
KW - immunity
KW - immunization
KW - immunostimulation
KW - interferon
KW - interleukin 2
KW - interleukin 4
KW - medicinal fungi
KW - medicinal plants
KW - pharmacology
KW - polysaccharides
KW - tumour necrosis factor
KW - vaccines
KW - Agaricomycotina
KW - Angelica
KW - mice
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Basidiomycota
KW - fungi
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Polyporaceae
KW - Polyporales
KW - Agaricomycetes
KW - Agaricomycotina
KW - Araliales
KW - Basidiomycetes
KW - Basidiomycotina
KW - cachectin
KW - cachexin
KW - complex carbohydrates
KW - coriolaceae
KW - drug plants
KW - fungus
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Macrohyporia
KW - Macrohyporia extensa
KW - medicinal herbs
KW - officinal plants
KW - Poriales
KW - tumor necrosis factor
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000309286&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Halogenated-polycyclic aromatic hydrocarbons: a class of genotoxic environmental pollutants.
AU - Fu, P. P.
AU - Tungeln, L. S. von
AU - Chiu LiHsueh
AU - Own ZangYuan
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis and Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis and Ecotoxicology Reviews
Y1 - 1999///
VL - 17
IS - 2
SP - 71
EP - 109
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 20002009288. Publication Type: Journal Article. Language: English. Number of References: 131 ref.
KW - aromatic compounds
KW - aromatic hydrocarbons
KW - genotoxicity
KW - pollutants
KW - aromatics
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Pollution and Degradation (PP600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002009288&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current status and future priorities for rotavirus vaccine development, evaluation and implementation in developing countries.
AU - Bresee, J. S.
AU - Glass, R. I.
AU - Ivanoff, B.
AU - Gentsch, J. R.
JO - Vaccine
JF - Vaccine
Y1 - 1999///
VL - 17
IS - 18
SP - 2207
EP - 2222
SN - 0264-410X
AD - Bresee, J. S.: Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Mailstop GO4, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 19992006095. Publication Type: Journal Article. Language: English. Number of References: 148 ref. Subject Subsets: Tropical Diseases
KW - human diseases
KW - reviews
KW - vaccine development
KW - vaccines
KW - Developing Countries
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - countries
KW - Third World
KW - Underdeveloped Countries
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006095&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki syndrome among American Indian and Alaska Native children, 1980 through 1995.
AU - Holman, R. C.
AU - Belay, E. D.
AU - Clarke, M. J.
AU - Kaufman, S. F.
AU - Schonberger, L. B.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 1999///
VL - 18
IS - 5
SP - 451
EP - 455
SN - 0891-3668
AD - Holman, R. C.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19992008768. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Indian Health Service computerized records of hospital discharges in the USA were examined for American Indian and Alaska Native (AI/AN) children <18 years of age with Kawasaki disease during 1980-95. During this period, 85 AI/AN children were reported with a hospitalization for Kawasaki disease; 10 of the children had an additional Kawasaki disease hospitalization record within 5 months. The average annual Kawasaki disease hospitalization rate for children <5 years of age, based on first Kawasaki disease hospitalization only, was 4.3 cases per 100 000 children; the rate for children age <1 year (n=21) was 8.6 per 100 000 and for children aged 1 to 4 years was 3.6 per 100 000. The annual rates for children <5 years of age ranged from 0 to 8.5 per 100 000 children. Kawasaki disease hospitalizations for children peaked in January and February; 50.6% of the children were hospitalized during January to April. The overall median length of hospital stay was 4 days (range, 1 to 29 days); the median duration decreased from 8 days during 1980-82 to 4 days during 1993-95. The overall annual hospitalization rate of Kawasaki disease among AI/AN children <5 years of age was slightly lower than rates for several majority white populations in the USA. (4.6 to 15.2 cases per 100 000) and much lower than rates for blacks and Asians/Pacific Islanders.
KW - Alaska Natives
KW - American indians
KW - blacks
KW - children
KW - disease prevalence
KW - epidemiology
KW - ethnic groups
KW - human diseases
KW - Kawasaki disease
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - hospitalizations
KW - mucocutaneous lymph node syndrome
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor.
AU - Ishii, K. J.
AU - Weiss, W. R.
AU - Klinman, D. M.
JO - Vaccine
JF - Vaccine
Y1 - 1999///
VL - 18
IS - 7/8
SP - 703
EP - 710
SN - 0264-410X
AD - Ishii, K. J.: Retroviral Immunology Section, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A Room 3 D 10, Bethesda, MD 20892, USA.
N1 - Accession Number: 20000804891. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 308067-58-5, 9008-11-1. Subject Subsets: Protozoology
N2 - A plasmid DNA vaccine encoding the circumsporozoite protein of Plasmodium yoelii (pCSP) induces protective immunity in adult mice but persistent tolerance when administered to neonates. In an effort to improve antigen presenting cell (APC) function in newborn mice, pCSP was co-administered with a plasmid encoding granulocyte-macrophage colony stimulating factor (pGMCSF). This combination of plasmids prevented the development of neonatal tolerance and instead elicited a primary IgG anti-CSP immune response. Mice primed as neonates and boosted as adults mounted anamnestic responses characterized by high serum antibody titres, cytotoxic T-cell activity and antigen-specific interferon-γ production. Neonatal administration of pGMCSF accelerated the maturation of local dendritic cells, suggesting that APC function plays a key role in determining whether tolerance or immunity results from neonatal exposure to antigen.
KW - antigens
KW - circumsporozoite protein
KW - colony stimulating factor
KW - cytotoxic T lymphocytes
KW - dendritic cells
KW - disease models
KW - DNA vaccines
KW - experimental infections
KW - granulocytes
KW - IgG
KW - immune response
KW - immunity
KW - immunization
KW - interferon
KW - laboratory animals
KW - macrophages
KW - malaria
KW - neonates
KW - parasites
KW - plasmids
KW - tolerance
KW - vaccine development
KW - mice
KW - Plasmodium yoelii
KW - protozoa
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - antigenicity
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - newborn infants
KW - Host Resistance and Immunity (HH600)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A liquid chromatographic method for the analysis of retinyl acetate in soy based infant formula using matrix solid phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1999///
VL - 22
IS - 8
SP - 1205
EP - 1212
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth Street, Atlanta, GA 30309, USA.
N1 - Accession Number: 19991408303. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 68-26-8, 127-47-9. Subject Subsets: Human Nutrition; Soyabeans
N2 - Retinyl acetate in soyabean-based infant formula was extracted by matrix solid phase dispersion (MSPD) and chromatographed by isocratic normal phase chromatography on a Si 60 column with a mobile phase of 0.28% (v/v) isopropanol in hexane. Detection was by fluorescence (Ex λ=325, Em λ=470). Fluorescence response was linear (r²=0.999) from 0.10 to 2.5 µg/ml. Recoveries determined on a soyabean-based infant formula zero control reference material (ZRM) containing added analyte at 5 levels averaged 94.7% (n=25) with CVs from 0.57-3.53%. The method expands the use of MSPD extraction to the analysis of retinyl acetate in soyabean-based infant formulas.
KW - analytical methods
KW - chromatography
KW - composition
KW - infant formulae
KW - retinol
KW - retinyl acetate
KW - soyabean products
KW - analytical techniques
KW - axerophthol
KW - infant formula
KW - infant formulas
KW - retinol acetate
KW - soybean products
KW - vitamin A
KW - vitamin A acetate
KW - vitamin A alcohol
KW - vitamin A1
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toroidal coil countercurrent chromatography separation and analysis of staphylococcal enterotoxin A (SEA) in milk.
AU - Rasooly, A.
AU - Ito, Y.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1999///
VL - 22
IS - 9
SP - 1285
EP - 1293
AD - Rasooly, A.: Division of Microbiological Studies, U.S. Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 19990403386. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Countercurrent chromatography (CCC) utilizes continuous partitioning of solute between 2 immiscible solvent phases without a solid support. The absence of solid support makes CCC a suitable method for food analysis because it permits analysis of crude and complex materials that are not amenable to conventional solid-supported chromatography. CCC was used to separate SEA from milk. Although many foods can be analysed for SEA directly by Western blot analysis, milk samples generally require purification because the high concentration of milk proteins distorts SDS-PAGE mobility. Milk samples containing SEA were separated by toroidal coil CCC and the fractions were analysed by Western immunoblotting. Fractions containing SEA were pooled, concentrated by ultrafiltration, and rechecked by Western immunoblotting. Concentrating the fractions increased the sensitivity of Western immunoblotting by 1 order of magnitude.
KW - analytical methods
KW - chromatography
KW - enterotoxins
KW - microbial contamination
KW - milk
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sulfamethazine and its major metabolites in egg albumin and egg yolk by high performance liquid chromatography.
AU - Shaikh, B.
AU - Rummel, N.
AU - Donoghue, D.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 1999///
VL - 22
IS - 17
SP - 2651
EP - 2662
AD - Shaikh, B.: U. S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 19992217056. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 110-54-3, 57-68-1. Subject Subsets: Veterinary Science; Veterinary Science; Poultry
N2 - A quantitative liquid chromatographic method for the determination of sulfamethazine [sulfadimidine] (SMZ), N4-acetyl sulfamethazine (N4-acetyl-SMZ) and desamino sulfamethazine (desamino-SMZ) in egg albumin and egg yolk is described. Egg albumin or yolk was homogenized in acetonitrile and centrifuged. The supernatant was evaporated to dryness and residue reconstituted in the mobile phase. Albumin extract was directly analysed by HPLC. Hexane was added to the yolk sample, vortex mixed, and centrifuged to separate the layers. The top hexane layer was removed and a small amount of salt was added to break the emulsions. The lower aqueous layer was analysed by HPLC. The HPLC system included a reversed phase column, a gradient mobile phase of 5-15% acetonitrile and 0.01 M phosphate buffer, and a UV detector set at 268 nm. The recovery of SMZ and N4-acetyl-SMZ, both fortified at 1 ppm levels, from egg albumin was 101 and 88% and from egg yolk was 79 and 91%, respectively. The recovery of desamino-SMZ at 2 ppm fortification level from egg albumin and egg yolk was 84 and 63%, respectively. The method was applied to detect the presence of SMZ and its potential metabolites in eggs collected after dosing hens with SMZ. Parent drug, SMZ, was the major compound transferred to both egg albumin and yolk. Small concentrations of N4-acetyl-SMZ metabolite were also detected in some eggs; however, no desamino-SMZ or other metabolites were detected.
KW - albumins
KW - detection
KW - drug metabolism
KW - drug residues
KW - egg yolk
KW - eggs
KW - emulsions
KW - food hygiene
KW - food safety
KW - hexane
KW - laboratory methods
KW - metabolites
KW - methodology
KW - sulfadimidine
KW - techniques
KW - laboratory techniques
KW - methods
KW - sulfamethazine
KW - sulphadimidine
KW - yolk
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of overweight and obesity in American Indian school children and adolescents in the Aberdeen area: a population study.
AU - Zephier, E.
AU - Himes, J. H.
AU - Story, M.
JO - International Journal of Obesity
JF - International Journal of Obesity
Y1 - 1999///
VL - 23
SP - S28
EP - S30
SN - 0307-0565
AD - Zephier, E.: Aberdeen Area Indian Health Service, Federal Building, Room 309, 115 4th Avenue SE, Aberdeen, SD 57401, USA.
N1 - Accession Number: 19991406468. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - 13 810 American Indian children and adolescents (aged 5-17 years) attending 58 schools affiliated with 16 tribes, in the Aberdeen area Indian Health Service (including South Dakota, North Dakota, Iowa, Nebraska) were recruited. Stature and weight were measured for 12 559 children (1995-96) and prevalences of overweight and obesity were determined relative to gender and age-specific national reference data (Second national Health and Nutrition Examination Survey) for the body mass index (BMI). Those with BMI >85th percentile were considered overweight and those with BMI >95th percentile were considered obese. Age-adjusted prevalences of overweight were 39.1 and 38.0% for males and females, respectively, and corresponding age-adjusted prevalences for obesity were 22.0 and 18.0%, respectively. There were few regular changes in prevalences of overweight across ages for either gender, or for obesity in females. Prevalences of obesity in males increased systematically with age and exceed prevalences in females at many ages. Overweight and obesity based on elevated BMI are highly prevalent among American Indian youth. Even at the youngest school ages, overweight is more than twice as likely as national patterns and obesity is more than three times as prevalent.
KW - adolescents
KW - American indians
KW - anthropometric dimensions
KW - body weight
KW - children
KW - ethnic groups
KW - height
KW - nutritional state
KW - obesity
KW - overweight
KW - sex differences
KW - Iowa
KW - Nebraska
KW - North Dakota
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - Great Plains States of USA
KW - Northern Plains States of USA
KW - anthropometric measurements
KW - fatness
KW - nutritional status
KW - teenagers
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Reproduction and Development (VV060)
KW - Social Structure (UU480) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Geographic survey of vector ticks (Ixodes scapularis and Ixodes pacificus) for infection with the Lyme disease spirochete, Borrelia burgdorferi.
AU - Piesman, J.
AU - Clark, K. L.
AU - Dolan, M. C.
AU - Happ, C. M.
AU - Burkot, T. R.
JO - Journal of Vector Ecology
JF - Journal of Vector Ecology
Y1 - 1999///
VL - 24
IS - 1
SP - 91
EP - 98
SN - 1081-1710
AD - Piesman, J.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department Health and Human Services, PO Box 2087, Ft. Collins, CO 80522, USA.
N1 - Accession Number: 19990505984. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Populations of adult I. scapularis and I. pacificus were collected from 17 sites in 12 states of the USA. Female ticks were fed on experimental rabbits; ticks and rabbits were subsequently examined for infection with B. burgdorferi. 14 rabbits were exposed to I. scapularis ticks from Connecticut, New York, New Jersey and Maryland; all 14 rabbits became infected with B. burgdorferi. A total of 165 of 226 (73%) of these northeastern ticks was infected. Similarly, ticks from Michigan, Wisconsin and Minnesota transmitted infection to all 3 exposed rabbits; 29 of 51 (57%) of these midwestern I. scapularis were infected. In marked contrast, none of the 12 rabbits exposed to I. scapularis ticks from the southeastern states of South Carolina, Georgia, Florida and Mississippi acquired infection with B. burgdorferi, and 0 of 284 (0%) of these ticks contained spirochaetes. Four rabbits were exposed to I. pacificus collected from 1 location in California; 2 of 4 of these rabbits acquired infection and 2 of 57 (4%) of the I. pacificus were infected with B. burgdorferi. The antigenic profiles of all 58 strains tested were consistent with an identity of B. burgdorferi s.l.
KW - antigens
KW - disease surveys
KW - disease vectors
KW - ectoparasites
KW - epidemiology
KW - laboratory animals
KW - Lyme disease
KW - California
KW - Connecticut
KW - Florida
KW - Georgia
KW - Maryland
KW - Michigan
KW - Minnesota
KW - Mississippi
KW - New Jersey
KW - New York
KW - South Carolina
KW - USA
KW - Wisconsin
KW - Acari
KW - Arachnida
KW - Borrelia burgdorferi
KW - Ixodes
KW - Ixodes pacificus
KW - Ixodes scapularis
KW - rabbits
KW - spirochaetes
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Leporidae
KW - Lagomorpha
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - New England States of USA
KW - Northeastern States of USA
KW - Gulf States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - East North Central States of USA
KW - North Central States of USA
KW - Lake States of USA
KW - West North Central States of USA
KW - Delta States of USA
KW - East South Central States of USA
KW - Middle Atlantic States of USA
KW - antigenicity
KW - bacterium
KW - disease surveillance
KW - immunogens
KW - lyme borreliosis
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - WHO consultation on diagnostic procedures for Transmissible Spongiform Encephalopathies: need for reference reagents and reference panels. Geneva, Switzerland, 22-23 March 1999.
AU - Asher, D. M.
AU - Padilla, A. M.
AU - Pocchiari, M.
JO - Biologicals
JF - Biologicals
Y1 - 1999///
VL - 27
IS - 3
SP - 265
EP - 272
SN - 1045-1056
AD - Asher, D. M.: Laboratory of Method Development, Division of Viral Products, Office of Vaccine Research and Review. Centre for Biologics, Evaluation and Research, United States Food and Drug Administration, HFM-470 FDA, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20002010142. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 19 ref.
KW - diagnosis
KW - human diseases
KW - spongiform encephalopathy
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - procedures
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis.
AU - Meyerhoff, A.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1999///
VL - 28
IS - 1
SP - 42
EP - 48
SN - 1058-4838
AD - Meyerhoff, A.: Division of Special Pathogens and Immunologic Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, 9201 Corporate Boulevard HFD-590, Rockville, MD 20850, USA.
N1 - Accession Number: 19990802233. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 1397-89-3. Subject Subsets: Protozoology
N2 - In August 1997, AmBisome (liposomal amphotericin B) was the first drug approved for the treatment of visceral leishmaniasis by the US Food and Drug Administration. The data submitted in support of the New Drug Application for AmBisome for the treatment of visceral leishmaniasis are discussed.
KW - amphotericin B
KW - antiprotozoal agents
KW - clinical aspects
KW - clinical trials
KW - drugs
KW - liposomes
KW - parasites
KW - visceral leishmaniasis
KW - Leishmania
KW - protozoa
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - AmBisome
KW - approval
KW - clinical picture
KW - liposomal amphotericin B
KW - medicines
KW - pharmaceuticals
KW - US Food and Drug Administration
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802233&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Escherichia coli O157:H7 outbreak associated with an improperly chlorinated swimming pool.
AU - Friedman, M. S.
AU - Roels, T.
AU - Koehler, J. E.
AU - Feldman, L.
AU - Bibb, W. F.
AU - Blake, P.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1999///
VL - 29
IS - 2
SP - 298
EP - 303
SN - 1058-4838
AD - Friedman, M. S.: Zuni Health Center, Indian Health Service, P.O. Box 467, Zuni, NM 87327, USA.
N1 - Accession Number: 20002007124. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7782-50-5, 308067-58-5.
N2 - A cluster of gastrointestinal illnesses, including one case of haemolytic-uremic syndrome and one culture-confirmed Escherichia coli O157:H7 infection, followed a trailer park pool party in Georgia, USA, in July 1996. A cohort of party attendees and park residents were interviewed. A primary case was defined as the first gastrointestinal illness within a household during 5 July and 20 July in which the titre of IgG antibody to E. coli O157 (if determined) was elevated. Of 51 party attendees and trailer park residents, 18 developed a gastrointestinal illness, including 10 who met the definition of a primary case. Swimming in the pool significantly increased the risk of primary illness (relative risk=6.3; 95% confidence interval=1.8-18.9). No other exposure was significantly associated with primary illness, after pool exposure was controlled for. The implicated pool had little to no chlorine added during the period of 4-10 July. This outbreak provides new evidence of the importance of proper pool maintenance in controlling the spread of E. coli O157:H7.
KW - antibodies
KW - chlorine
KW - digestive system
KW - households
KW - human diseases
KW - IgG
KW - infections
KW - outbreaks
KW - swimming pools
KW - Georgia
KW - USA
KW - Escherichia
KW - Escherichia coli
KW - man
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - alimentary tract
KW - bacterium
KW - E. coli
KW - gastrointestinal system
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007124&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora.
AU - Cerniglia, C. E.
AU - Kotarski, S.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 1999///
VL - 29
IS - 3
SP - 238
EP - 261
SN - 0273-2300
AD - Cerniglia, C. E.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20002209715. Publication Type: Journal Article. Language: English. Number of References: 4 pp. of ref. Subject Subsets: Veterinary Science; Human Nutrition
N2 - Different in vivo and in vitro experiment test systems and approaches used by animal health industries, contract laboratories and regulatory authorities to assess the safety of veterinary drug residues in foods for human consumption are reviewed. The effects of drug residues on gut microflora are discussed.
KW - drug residues
KW - drugs
KW - food
KW - food safety
KW - intestinal microorganisms
KW - microbial flora
KW - reviews
KW - safety
KW - veterinary products
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal health products
KW - gut flora
KW - intestinal micro-organisms
KW - medicines
KW - microflora
KW - pharmaceuticals
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002209715&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Expression and characterisation of a Plasmodium falciparum protein containing domains homologous to sarcalumenin and a tyrosine kinase substrate, eps15.
AU - McDaniel, J. P.
AU - Syin Chiang
AU - Lin, D. T.
AU - Joshi, M. B.
AU - Li ShiPeng
AU - Goldman, N. D.
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 1999///
VL - 29
IS - 5
SP - 723
EP - 730
SN - 0020-7519
AD - McDaniel, J. P.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19990805609. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology
N2 - A novel gene encoding a putative bifunctional protein (PfPast-1) was identified in Plasmodium falciparum from genomic and complementary DNA libraries. The sequence encodes a 62 kDa protein of 529 amino acid residues with 2 distinctive domains: a sarcalumenin-like domain of approximately 320 amino acids at the amino half of the molecule, which shares homology to a major sarcoplasmic reticulum lumenal protein (sarcalumenin), and an eps15 homology domain of about 90 amino acids located at the carboxyl terminus. The eps15 homology domain, first identified in a tyrosine kinase substrate (eps15) and found in increasing numbers of mammalian proteins, has recently been suggested as a protein-protein interaction domain involved in intracellular sorting. Genomic sequences encoding similar proteins containing both the sarcalumenin-like and eps15 homology domains have been identified in humans and Drosophila. RNA blot analysis revealed the presence of a single messenger RNA transcript ~ 3.7 kb in size, which was expressed in all the developmental stages examined with the highest level in extracellular gametes followed by erythrocytic asexual stages, and the lowest in the gametocytes. In an attempt to define its biological function, a full-length recombinant PfPast-1 protein was expressed in Escherichia coli. Specific immune serum directed against the recombinant protein recognised an ~55 kDa protein in the parasite lysate. Nucleotide sequence data have been submitted to GenBank under accession number U84395.
KW - amino acid sequences
KW - amino acids
KW - complementary DNA
KW - development
KW - developmental stages
KW - DNA libraries
KW - gene expression
KW - genes
KW - messenger RNA
KW - molecular genetics
KW - nucleotide sequences
KW - parasites
KW - proteins
KW - recombinant proteins
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - cDNA
KW - DNA sequences
KW - growth phase
KW - mRNA
KW - PfPast-1
KW - protein sequences
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805609&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal variation of Acinetobacter infections: 1987-1996.
AU - McDonald, L. C.
AU - Banerjee, S. N.
AU - Jarvis, W. R.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 1999///
VL - 29
IS - 5
SP - 1133
EP - 1137
SN - 1058-4838
AD - McDonald, L. C.: Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20002005203. Publication Type: Journal Article. Corporate Author: USA, National Nosocomial Infections Surveillance System Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - To determine whether nosocomial infections due to Acinetobacter species have increased over the past 10 years and whether infections continue to have a pronounced seasonal variance, infections reported by hospitals in the National Nosocomial Infections Surveillance System that performed adult and paediatric intensive care unit surveillance during 1987-96, in the USA, were analysed. Overall, 3447 nosocomial Acinetobacter infections were reported during 5 596 196 patient-days. There was a yearly median of 7.2 infections (range, 5.0-10.5) per 10 000 patient-days and a downward trend in the rate of Acinetobacter infections overall (P<0.05) and of 2 major types of infection (P<0.05): bloodstream infections (yearly median, 1.6/10 000 central venous catheter-days; range, 1.3-2.9) and pneumonia (yearly median, 7.6/10 000 ventilator-days; range, 6.5-12.0). Throughout the period, average rates were significantly higher during July-October than during November-June for Acinetobacter infection overall (8.0 vs. 5.2; P<0.01) and bloodstream infections (2.0 vs. 1.2; P<0.01) and pneumonia (9.7 vs. 6.6; P<0.01).
KW - bacteraemia
KW - bacterial diseases
KW - blood
KW - epidemiology
KW - hospitals
KW - human diseases
KW - intensive care units
KW - lungs
KW - nosocomial infections
KW - pneumonia
KW - seasonal variation
KW - surveillance
KW - USA
KW - Acinetobacter
KW - man
KW - Moraxellaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacteremia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - hospital infections
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002005203&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes.
AU - Hammons, G. J.
AU - Fletcher, J. V.
AU - Stepps, K. R.
AU - Smith, E. A.
AU - Balentine, D. A.
AU - Harbowy, M. E.
AU - Kadlubar, F. F.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 1999///
VL - 33
IS - 1
SP - 46
EP - 52
CY - Mahwah; USA
PB - Lawrence Erlbaum Associates Inc.
SN - 0163-5581
AD - Hammons, G. J.: Division of Molecular Epidemiology, National Center of Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20003008770. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Human Nutrition
N2 - Carcinogenic aromatic amines, including the heterocyclic amines, may pose a significant health risk to humans. To determine the potential for chemoprotective intervention against the carcinogenicity of these arylamines and to better understand their mechanism of action, a range of agents, most of them natural dietary constituents, was examined in vitro for their ability to modulate the N-hydroxylation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 4-aminobiphenyl (ABP), an initial step in their bioactivation. Experiments were conducted with rat and human liver microsomes. The agents (diallyl sulfide, indole-3-carbinol, α-angelicalactone, cafestol/kahweol palmitates, cafestol, kahweol, benzylisothiocyanate, genistin, formononetin, daidzin, equol, biochanin A, Oltipraz, tannic acid, quercetin, ethoxyquin, green tea, and black tea) comprised a variety of chemical classes that included sulfur-containing compounds, antioxidants, flavonoids, phytoestrogens, diterpenes, and polyphenols. Several of these agents, quercetin, ethoxyquin, and black tea, were found to strongly inhibit PhIP N-hydroxylation in rat liver microsomes, resulting in a nearly 85-90% decrease in activity at 100 µM or 0.2%. Tannic acid and green tea, in addition to these agents, were also strong inhibitors of ABP N-hydroxylation. In human liver microsomes, each of these agents was strongly inhibitory (approx 85-95% at 100 µM or 0.02%) of PhIP and ABP N-hydroxylation. Theaflavins and polyphenols were judged to be the primary inhibiting components in the teas, the theaflavins showing the most potent effect. These results demonstrate that chemoprotective agents can inhibit the bioactivation of carcinogenic arylamines, and this is likely to be one of the mechanisms of protection.
KW - amines
KW - antioxidants
KW - carcinogenesis
KW - diterpenes
KW - flavonoids
KW - inhibition
KW - liver
KW - microsomes
KW - mode of action
KW - organic sulfur compounds
KW - plant oestrogens
KW - polyphenols
KW - man
KW - rats
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - aromatic amines
KW - arylamines
KW - organic sulphur compounds
KW - organosulphur compounds
KW - phytoestrogens
KW - plant estrogens
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003008770&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: a comparison with patterns in the liver.
AU - Sotomayor, R. E.
AU - Saura Sahu
AU - Washington, M.
AU - Hinton, D. M.
AU - Chou Ming
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
Y1 - 1999///
VL - 33
IS - 4
SP - 293
EP - 302
SN - 0893-6692
AD - Sotomayor, R. E.: Center for Food Safety and Applied Nutrition, Food and Drug Administration (HFS-509), MOD-1, 8301 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20001201939. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2, 50812-37-8. Subject Subsets: Medical & Veterinary Mycology
N2 - Fisher-344 male rats were fed 1.6 p.p.m. of aflatoxin B1 (AFB1) continuously and intermittently for several weeks. At various time periods, DNA was isolated from the testes and livers and analysed for AFB1-DNA adducts. The ability of the testis to detoxify AFB1 was also investigated by the glutathione S-transferase (GST) activity assay and compared with that of the liver. The levels of testicular AFB1-DNA adducts were 2.4- to 8.1-fold lower than those of the liver after 4-16 weeks of continuous treatment, and 2.2- to 46.2-fold lower after 8 to 20 weeks of intermittent treatment. The testicular DNA adducts markedly decreased over time. By 16 weeks of continuous and 20 weeks of intermittent exposure, they had decreased 37 and 91%, respectively. In contrast, hepatic AFB1-DNA adducts increased 4-fold from 4 to 16 weeks of continuous treatment but increased at a much slower rate after intermittent exposure. In both the liver and testis, significant levels of AFB1-DNA adducts persisted for at least 1 month after ending the treatment, suggesting that this type of lesion was poorly repaired. In control rats, the testis showed significantly higher GST activity than the liver. In treated rats, these differences were significant during the first 12 weeks of continuous treatment but not at later times. It is suggested that tissue-specific differences such as germ-cell depletion and increased testicular detoxification may play an important role in the observed differential pattern of DNA adduct formation between the testis and liver.
KW - aflatoxicosis
KW - aflatoxins
KW - carcinogenesis
KW - DNA
KW - glutathione transferase
KW - liver
KW - mycotoxins
KW - poisoning
KW - testes
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin poisoning
KW - deoxyribonucleic acid
KW - fungal toxins
KW - ligandin
KW - testicles
KW - toxicosis
KW - Toxinology (VV820) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001201939&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of manganese on the concentration of amino acids in different regions of the rat brain.
AU - Lipe, G. W.
AU - Duhart, H.
AU - Newport, G. D.
AU - Slikker, W., Jr.
AU - Ali, S. F.
JO - Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes
JF - Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes
Y1 - 1999///
VL - 34
IS - 1
SP - 119
EP - 132
AD - Lipe, G. W.: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991406084. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 56-84-8, 56-12-2, 56-86-0, 56-85-9, 7439-96-5, 107-35-7. Subject Subsets: Human Nutrition
N2 - The study examined whether chronic exposure of rats to Mn produces significant alterations in amino acid concentrations in different regions of the rat brain. Weanling (30 days old) and adult (90 days old) male rats were exposed to 10 and 20 mg Mn/kg body weight daily, by gavage, for 30 days. 48 h after the last dose, animals were sacrificed by decapitation and brains were dissected into different regions to determine the concentration of amino acids by HPLC/EC. A dose dependent decrease in body weight gain was found in the adult, but not in the weanling, rats. Significant increases occurred in concentrations of aspartate, glutamate, glutamine, taurine and γ-aminobutyric acid (GABA) in the cerebellum of the adult rats dosed with Mn 20 mg/kg per day. A significant decrease in the concentration of glutamine was observed in caudate nucleus and hippocampus of weanling rats dosed with Mn 10 mg/kg. These data suggest that chronic Mn exposure can produce a decrease in body weight gain in adult rats and alterations in amino acids in different regions of weanling and adult rat brains.
KW - age
KW - amino acids
KW - aspartic acid
KW - brain
KW - gamma-aminobutyric acid
KW - glutamic acid
KW - glutamine
KW - manganese
KW - taurine
KW - weaning
KW - weight gain
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - GABA
KW - Mn
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991406084&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid screening for organochlorine and organophosphorus pesticides in milk using C18 and graphitized carbon black solid phase extraction cleanup.
AU - Schenck, F. J.
AU - Casanova, J.
JO - Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes
JF - Journal of Environmental Science and Health. Part B, Pesticides, Food Contaminants, and Agricultural Wastes
Y1 - 1999///
VL - 34
IS - 3
SP - 349
EP - 362
AD - Schenck, F. J.: U.S. Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 19991105632. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Agricultural Entomology; Dairy Science
N2 - A rapid, multiresidue, solid phase extraction (SPE) technique for the isolation and gas chromatographic determination of organochlorine and moderately polar organophosphorus pesticide residues in milk is described. Milk is sonicated with an acetonitrile-acetone-methanol mixture and centrifuged. The supernatant is subjected to a cleanup using both C18 and graphitized carbon black SPE columns. The pesticide residues are determined by gas chromatography with electron capture and flame photometric detection. The method required minimal volumes of solvent and resulted in the production of minimal volumes of hazardous waste.
KW - agricultural entomology
KW - analytical methods
KW - chromatography
KW - determination
KW - extraction
KW - gas chromatography
KW - milk
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - residues
KW - screening
KW - analytical techniques
KW - organic chlorine pesticides
KW - screening tests
KW - Pesticides and Drugs (General) (HH400)
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991105632&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved separation of conjugated fatty acid methyl esters by silver ion-high-performance liquid chromatography.
AU - Najibullah Sehat
AU - Rickert, R.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - Adlof, R. O.
AU - Morehouse, K. M.
AU - Fritsche, J.
AU - Eulitz, K. D.
AU - Steinhart, H.
AU - Ku Yuoh
JO - Lipids
JF - Lipids
Y1 - 1999///
VL - 34
IS - 4
SP - 407
EP - 413
SN - 0024-4201
AD - Najibullah Sehat: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19991410375. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 60-33-3. Subject Subsets: Human Nutrition
N2 - Operating from 1 to 6 silver ion-HPLC (Ag+-HPLC) columns in series progressively improved the resolution of the methyl esters of conjugated linoleic acid (CLA) isomeric mixtures from natural and commercial products. In natural products, the 8 trans, 10 cis-octadecadienoic (18:2) acid was resolved from the more abundant 7 trans, 9 cis-18:2, and the 10 trans, 12 cis-18:2 was separated from the major 9 cis, 11 trans-18:2 peak. In addition, both 11 trans, 13 cis-18:2 and 11 cis, 13 trans-18:2 isomers were found in natural products and were separated; the presence of the latter, 11 cis, 13 trans-18:2, was established in commercial CLA preparations. Three Ag+-HPLC columns in series appeared to be the best compromise to obtain satisfactory resolution of most CLA isomers found in natural products. A single Ag+-HPLC column in series with one of several normal-phase columns did not improve the resolution of CLA isomers as compared to that of the former alone. The 20:2 conjugated fatty acid isomers 11 cis, 13 trans-20:2 and 12 trans, 14 cis-20:2, which were synthesized by alkali isomerization from 11 cis, 14 cis-20:2, eluted in the same region of the Ag+-HPLC chromatogram just before the corresponding geometric CLA isomers. Therefore, CLA isomers will require isolation based on chain length prior to Ag+-HPLC separation. The positions of conjugated double bonds in 20:2 and 18:2 isomers were established by gas chromatography-electron ionization mass spectrometry as their 4,4-dimethyloxazoline derivatives. The double-bond geometry was determined by gas chromatography-direct deposition-Fourier transform infrared spectroscopy and by the Ag+-HPLC relative elution order.
KW - analytical methods
KW - characterization
KW - fatty acids
KW - HPLC
KW - isomers
KW - linoleic acid
KW - separation
KW - analytical techniques
KW - high performance liquid chromatography
KW - separating
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410375&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of peanut oil and randomized peanut oil on cholesterol and oleic acid absorption, transport, and distribution in the lymph of the rat.
AU - Subramaniam Satchithanandam
AU - Flynn, T. J.
AU - Calvert, R. J.
AU - Kritchevsky, D.
JO - Lipids
JF - Lipids
Y1 - 1999///
VL - 34
IS - 12
SP - 1305
EP - 1311
SN - 0024-4201
AD - Subramaniam Satchithanandam: Divisions of Science and Applied Technology, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA.
N1 - Accession Number: 20001413541. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 57-88-5, 8002-03-7, 112-80-1. Subject Subsets: Human Nutrition
N2 - Peanut [groundnut] oil was shown to be atherogenic in cholesterol-fed rats, rabbits, and monkeys. However, after randomization, a process in which the fatty acids in peanut oil are randomly rearranged, its atherogenicity was significantly reduced in cholesterol-fed rabbits and monkeys. The mechanism for this effect remains unknown. This study was designed to investigate whether the absorption, transport and distribution of dietary cholesterol and oleic acid in the lymph were altered in the presence of peanut oil or randomized peanut oil. Previous investigators collected lymph through the mesenteric duct for 6 h and analysed lymph for cholesterol. In the present study, lymph fluids were collected at timed intervals for up to 8 h and then at 24 h via the thoracic duct. Cholesterol and oleic acid (fatty acid) were estimated not only in the whole lymph but also in lymph lipoprotein fractions and in major lipid fractions. A 24-h lymph collection will enhance accuracy as short-term fluctuations in lipid absorption will not affect the results. Thoracic duct lymph collection is quantitative compared to mesenteric duct lymph collection, which provides only a fraction of the total lymph. Rats were given a lipid emulsion containing either peanut oil or randomized peanut oil. The emulsion also contained cholesterol, oleic acid, and sodium taurocholate in saline and was given through a duodenal catheter. Results show that absorption, transport, and distribution of cholesterol and oleic acid in the lymph fluids were similar in both dietary groups. These results suggest that the atherogenicity of peanut oil may be due to other events taking place subsequent to the release of cholesterol-containing chylomicrons and very low density lipoprotein by the small intestinal epithelial cells into the blood or may be due to the triglyceride structure itself.
KW - absorption
KW - cholesterol
KW - chylomicron lipids
KW - diets
KW - distribution
KW - duodenum
KW - fatty acids
KW - groundnut oil
KW - intestines
KW - lipoproteins
KW - low density lipoprotein
KW - lymph
KW - oleic acid
KW - transport
KW - very low density lipoprotein
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arachis oil
KW - chylomicrons
KW - peanut oil
KW - transportation
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413541&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diagnosis of human ehrlichiosis by PCR assay of acute-phase serum.
AU - Comer, J. A.
AU - Nicholson, W. L.
AU - Sumner, J. W.
AU - Olson, J. G.
AU - Childs, J. E.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 1
SP - 31
EP - 34
SN - 0095-1137
AD - Comer, J. A.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers For Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Rd., Mailstop G-13, Atlanta, GA 30333, USA.
N1 - Accession Number: 19990503371. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A PCR assay of 43 acute-phase serum samples was evaluated as a method for early detection of human granulocytic ehrlichiosis (HGE) and determination of aetiology when serologic testing is inconclusive. Sequence-confirmed products of the HGE agent were amplified from 3 individuals residing or having exposure history in Minnesota or Wisconsin, USA, and similarly confirmed products from Ehrlichia chaffeensis were amplified from 3 individuals from Florida or Maryland, USA. Aetiology, as determined by PCR and serology, was the same whenever there was a 4-fold difference between the maximum titres of antibodies to both antigens, indicating that presumptive determination of aetiology may be based on 4-fold differences in titres. PCR testing determined that E. chaffeensis was the aetiologic agent for 1 individual who had similar titres of antibodies to both agents. PCR assay of acute-phase serum in the absence of whole blood specimens may be a useful method for early detection of human ehrlichiosis and determination of aetiology when serologic testing is inconclusive.
KW - aetiology
KW - antibodies
KW - antigens
KW - detection
KW - diagnosis
KW - human diseases
KW - polymerase chain reaction
KW - rickettsial diseases
KW - serology
KW - serum
KW - Florida
KW - Maryland
KW - Minnesota
KW - USA
KW - Wisconsin
KW - Ehrlichia chaffeensis
KW - man
KW - Ehrlichia
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Lake States of USA
KW - North Central States of USA
KW - West North Central States of USA
KW - East North Central States of USA
KW - antigenicity
KW - bacterium
KW - causal agents
KW - etiology
KW - human granulocytic ehrlichiosis
KW - immunogens
KW - PCR
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Coisolation of Streptococcus pneumoniae and Haemophilus influenzae from middle ear fluid and sputum: effect on MIC results.
AU - Elliott, J. A.
AU - Facklam, R. R.
AU - Nathan, C.
AU - Weinstein, R. A.
AU - Kauffmann, L.
AU - McAllister, J.
AU - Stadnik, P.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 1
SP - 277
EP - 277
SN - 0095-1137
AD - Elliott, J. A.: Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19992004959. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Public Health
N2 - An isolate from a middle ear aspirate was reported to be highly resistant to vancomycin (MIC ≥256 μg/ml). Following 24 h of growth on a Trypticase soy agar plate containing 5% defibrinated sheep blood (TSA-SB), the isolate was thought to be a pure culture of S. pneumoniae serotype 19F with a clear zone of inhibition around an optochin disk. However, the bacterial growth gave off a strong, non-characteristic odour, and after a further 24 h of growth, white colonies formed around the pneumococcal colonies and these were found to be H. influenzae serotype nontypable, biotype VII, which were vancomycin-resistant. The S. pneumoniae was purified by growth on a TSA-SB plate containing gentamicin and was retested for vancomycin susceptibility; the MIC was 0.25 μg/ml by microplate dilution. The isolated Haemophilus would only grow around living S. pneumoniae on a TSA-SB plate. Serotypes 23F, 6A, 14, 6B and 9V and a second serotype 19F strain of S. pneumoniae also supported the growth of the original middle ear fluid isolate of Haemophilus on TSA-SB. Other Haemophilus biotypes (I to VI and a second serotype VII) and serotypes (a to f) also grew on TSA-SB in association with the living S. pneumoniae of the various serotypes. A sputum sample was also received from which co-isolation of H. influenzae and S. pneumoniae occurred. The S. pneumoniae was originally thought to be penicillin resistant (>256 μg/ml), but when purified from the Haemophilus influenzae was found to be penicillin susceptible.
KW - detection
KW - ears
KW - human diseases
KW - mixed infections
KW - USA
KW - Haemophilus influenzae
KW - man
KW - Streptococcus pneumoniae
KW - Haemophilus
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - multiple infections
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type.
AU - Swan, D. C.
AU - Tucker, R. A.
AU - Tortolero-Luna, G.
AU - Mitchell, M. F.
AU - Wideroff, L.
AU - Unger, E. R.
AU - Nisenbaum, R. A.
AU - Reeves, W. C.
AU - Icenogle, J. P.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 4
SP - 1030
EP - 1034
SN - 0095-1137
AD - Swan, D. C.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19992006102. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - The association between human papillomavirus (HPV) DNA copy number and cervical disease was investigated. Viral DNA copy number for the most common high-risk HPV types in cervical cancer (types 16, 18, 31, and 45) was determined in cervical cytobrush specimens from 149 women with high-grade cervical intraepithelial neoplasias (CIN II-CIN III), 176 with low-grade CIN (CIN I), and 270 with normal cytology, in Texas, USA. Quantitative, PCR-based fluorescent assays for each of the HPV genotypes and for the β-globin gene were used. The amount of cellular DNA increased significantly with increasing disease; thus, HPV was expressed as copies per microgram of cellular DNA. The assay had a dynamic range of >107, allowing documentation for the first time of the wide range of HPV copy numbers seen in clinical specimens. Median HPV DNA copy number varied by more than 104 among the viral types. HPV16 was present in the highest copy number; over 55% of HPV16-positive samples contained more than 108 copies/µg. Median copy number for HPV16 showed dramatic increases with increasing epithelial abnormality, an effect not seen with the other HPV types. HPV16 increased from a median of 2.2×107 in patients with normal cytology, to 4.1×107 in CIN I patients, to 1.3×109 copies/µg in CIN II-III patients. Even when stratified by cervical disease and viral type, the range of viral DNA copies per microgram of cellular DNA was quite large, precluding setting a clinically significant cutoff value for "high" copy numbers predictive of disease. This study suggests that the clinical usefulness of HPV quantitation requires reassessment and is assay dependent.
KW - cervical cancer
KW - clinical aspects
KW - human diseases
KW - neoplasms
KW - pathology
KW - quantitative techniques
KW - viral load
KW - women
KW - Texas
KW - USA
KW - human papillomavirus 16
KW - human papillomaviruses
KW - man
KW - Papillomavirus
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - Papillomaviridae
KW - cancers
KW - clinical picture
KW - human papillomavirus
KW - Papovaviridae
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection by enzyme immunoassay of serum immunoglobulin G antibodies that recognize specific Cryptosporidium parvum antigens.
AU - Priest, J. W.
AU - Kwon, J. P.
AU - Moss, D. M.
AU - Roberts, J. M.
AU - Arrowood, M. J.
AU - Dworkin, M. S.
AU - Juranek, D. D.
AU - Lammie, P. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 5
SP - 1385
EP - 1392
SN - 0095-1137
AD - Priest, J. W.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Mail Stop F-13, Building 23, Room 1025, 4770 Buford Highway N.E., Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 19990805396. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Protozoology
N2 - Human infection with Cryptosporidium parvum usually elicits characteristic immunoglobulin G (IgG), IgA and IgM antibody responses against 2 sporozoite surface antigens with apparent MWs of ~27 and 17 kDa. It was shown that these 2 antigens are complex families of related antigens and 2 new ELISAs were developed for the detection and quantitation of serum IgG antibodies against both antigens. The assays utilize a recombinant form of the 27-kDa antigen and a partially purified native fraction isolated from sonicated whole oocysts that contains 17-kDa antigen. A previously developed immunoblot assay served as the reference seroassay for assessment of the new ELISAs. Positive responses with the recombinant-27-kDa-antigen ELISA were correlated with the immunoblot results for the 27-kDa antigen, with a sensitivity and specificity of 90 and 92%, respectively. Positive responses with the partially purified native-17-kDa-antigen ELISA correlated with the immunoblot results for the 17-kDa antigen, with a sensitivity and specificity of 90 and 94%, respectively. For both ELISAs the median IgG antibody levels for serum sets collected during outbreaks of waterborne C. parvum infection were at least 2.5-fold higher than the levels determined for a non-outbreak set. The new ELISAs were more specific and, in the case of the 27-kDa-antigen ELISA, more sensitive than the crude oocyst antigen ELISA currently in use.
KW - antibodies
KW - antigens
KW - ELISA
KW - IgA
KW - IgG
KW - IgM
KW - immune response
KW - immunoblotting
KW - immunodiagnosis
KW - immunoglobulins
KW - oocysts
KW - parasites
KW - recombinant antigens
KW - serum
KW - sporozoites
KW - surface antigens
KW - Cryptosporidium parvum
KW - protozoa
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antigenicity
KW - enzyme linked immunosorbent assay
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - PCR detection of Yersinia pestis in fleas: comparison with mouse inoculation.
AU - Engelthaler, D. M.
AU - Gage, K. L.
AU - Montenieri, J. A.
AU - Chu, M.
AU - Carter, L. G.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 6
SP - 1980
EP - 1984
SN - 0095-1137
AD - Engelthaler, D. M.: Division of Vector-borne Infectious Diseases/Centers for Disease Control and Prevention, Public Health Service, US Department of Health & Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 19990504571. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The "gold standard" for identifying Y. pestis-infected fleas has been inoculation of mice with pooled flea material. Inoculated mice are monitored for 21 days, and those that die are further analysed for Y. pestis infection by fluorescent-antibody assay and/or culture. PCR may provide a more rapid and sensitive alternative for identifying Y. pestis in fleas. To compare these assays, samples were prepared from 381 field-collected fleas (Oropsylla montana). Each flea was analysed individually by both PCR and mouse inoculation. 60 of the 381 flea samples were positive for Y. pestis by PCR; 48 of these PCR-positive samples caused death in mice (80.0% agreement). None of the 321 PCR-negative samples caused death. Among the 12 mice that survived inoculation with PCR-positive samples, 10 were later demonstrated by serology or culture to have been infected with Y. pestis. It is suggested that death of inoculated mice is less reliable than PCR as an indicator of the presence of Y. pestis in flea samples. Mouse inoculation assays produce results that are comparable to PCR only when surviving as well as dead mice are analysed for infection. The rapidity and sensitivity (10-100 CFU of Y. pestis) of PCR suggest that it could serve as a useful alternative to mouse inoculation for routine plague surveillance and outbreak investigations.
KW - detection
KW - inoculation
KW - laboratory animals
KW - mortality
KW - techniques
KW - Diamanus
KW - Diamanus montanus
KW - mice
KW - Oropsylla
KW - Siphonaptera
KW - Yersinia pestis
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Ceratophyllidae
KW - Siphonaptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Diamanus
KW - Oropsylla
KW - bacterium
KW - death rate
KW - Oropsylla montana
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition enzyme-linked immunosorbent assay for serotyping of group B streptococcal isolates.
AU - Arakere, G.
AU - Flores, A. E.
AU - Ferrieri, P.
AU - Frasch, C. E.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 8
SP - 2564
EP - 2567
SN - 0095-1137
AD - Arakere, G.: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 19992010320. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - A new inhibition enzyme-linked immunosorbent assay (ELISA) for serotyping group B streptococcus is reported. It is sensitive and specific compared to the conventional methods but does not need high-titred serotype-specific antisera, as the specificity is controlled by the polysaccharide coating on the ELISA plates. The method can also be quantitative, and was used to measure polysaccharide elaborated by different serotype V strains. It is concluded that the inhibition ELISA method will be useful in serotyping for epidemiological studies, assessing virulence, and performing strain selection for vaccine production.
KW - assays
KW - ELISA
KW - group B streptococci
KW - human diseases
KW - identification
KW - inhibition
KW - polysaccharides
KW - serotypes
KW - strains
KW - techniques
KW - man
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - complex carbohydrates
KW - enzyme linked immunosorbent assay
KW - Techniques and Methodology (ZZ900)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sensitive assays for isolation and detection of simian foamy retroviruses.
AU - Khan, A. S.
AU - Sears, J. F.
AU - Muller, J.
AU - Galvin, T. A.
AU - Shahabuddin, M.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 8
SP - 2678
EP - 2686
SN - 0095-1137
AD - Khan, A. S.: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, USA.
N1 - Accession Number: 19992213188. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 9068-38-6. Subject Subsets: Veterinary Science
N2 - A variety of sensitive assays for SFV isolation and detection which were developed with a prototype strain of SFV serotype 2 are described. The Mus dunni cell line (Journal of Virology (1984) 52, 695) was highly sensitive for SFV production on the basis of various general and specific retrovirus detection assays such as reverse transcriptase assay, transmission electron microscopy, immunofluorescence assay, and Western blotting. A highly sensitive polymerase chain reaction (PCR) assay was developed on the basis of the sequences in primary SFV isolates obtained from pig-tailed macaques (Macaca nemestrina) and rhesus macaques (Macaca mulatta). Analysis of naturally occurring SFV infection in macaques indicated that analysis by a combination of assays, including both highly sensitive, specific assays and less sensitive, broadly reactive assays, was important for evaluation of retrovirus infection.
KW - assays
KW - cell lines
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - disease transmission
KW - immunofluorescence
KW - polymerase chain reaction
KW - reverse transcriptase
KW - screening
KW - serotypes
KW - viral diseases
KW - zoonoses
KW - Macaca mulatta
KW - Macaca nemestrina
KW - monkeys
KW - Primates
KW - Retroviridae
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - fluorescent antibody technique
KW - IFAT
KW - PCR
KW - screening tests
KW - viral infections
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Laboratory Animal Science (LL040)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of Streck tissue fixative, a nonformalin fixative for preservation of stool samples and subsequent parasitologic examination.
AU - Nace, E. K.
AU - Steurer, F. J.
AU - Eberhard, M. L.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 1999///
VL - 37
IS - 12
SP - 4113
EP - 4119
SN - 0095-1137
AD - Nace, E. K.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20000804334. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 50-00-0, 9002-89-5. Subject Subsets: Helminthology; Protozoology
N2 - 140 individual stool specimens were collected in Haiti and parasites included Cyclospora cayetanensis, Giardia intestinalis, Entamoeba coli, Iodamoeba buetschlii, Endolimax nana, Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis and Necator americanus. Formalin, polyvinyl alcohol (PVA, mercuric chloride based) and Streck tissue fixative (STF) were compared by aliquoting faecal samples into each fixative. Preserved faecal samples were examined at 1 week, 1 month and 3 months to establish the quality of the initial preservation as well as the suitability of the fixative for long-term storage. At each time point, faecal samples in fixatives were examined microscopically: in wet mounts (with bright-field and epifluorescence microscopy); in modified acid-fast-, trichrome-, and safranin-stained smears; with 2 commercial test kits. At the time points examined, morphological features remained comparable for samples fixed with 10% formalin and STF. For comparisons of STF- and 10% formalin-fixed samples, specific findings revealed that Cyclospora oocysts retained full fluorescence, modified acid-fast- and safranin-stained smears of Cryptosporidium and Cyclospora oocysts were equal in staining quality and results were comparable in the immunofluorescence assay and enzyme immunoassay commercial kits. Faecal samples fixed in STF and stained with trichrome showed less-than-acceptable staining quality compared with stool fixed in PVA. It is concluded that STF provides an excellent substitute for formalin as a fixative in routine examination of faecal samples for parasites. However, modifications to the trichrome staining procedures will be necessary to improve the staining quality for protozoal cysts fixed in STF to a level comparable to that with PVA.
KW - alcohols
KW - cysts (developmental stages)
KW - diagnosis
KW - enzyme immunoassay
KW - faecal examination
KW - faeces
KW - formaldehyde
KW - helminth ova
KW - helminths
KW - human diseases
KW - oocysts
KW - parasites
KW - parasitoses
KW - poly(vinyl alcohol)
KW - specimen handling
KW - staining
KW - techniques
KW - Haiti
KW - Ascaris lumbricoides
KW - Cryptosporidium
KW - Cyclospora cayetanensis
KW - Endolimax nana
KW - Enoplida
KW - Entamoeba coli
KW - Giardia duodenalis
KW - man
KW - Necator americanus
KW - protozoa
KW - Rhabditida
KW - Strongyloides stercoralis
KW - Trichuris trichiura
KW - Ascaris
KW - Ascarididae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - Cyclospora
KW - Eimeriidae
KW - Endolimax
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Entamoeba
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Necator
KW - Ancylostomatidae
KW - Strongyloides
KW - Strongyloididae
KW - Trichuris
KW - Trichuridae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Enoplia
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Least Developed Countries
KW - Developing Countries
KW - Adenophorea
KW - Ascaridida
KW - fecal examination
KW - feces
KW - fixatives
KW - nematodes
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - Secernentea
KW - Strongylida
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An update of antidote availability in veterinary medicine.
AU - Post, L. O.
AU - Keller, W. C.
JO - Veterinary and Human Toxicology
JF - Veterinary and Human Toxicology
Y1 - 1999///
VL - 41
IS - 4
SP - 258
EP - 261
SN - 0145-6296
AD - Post, L. O.: Division of Epidemiology and Surveillance, Office of Surveillance and Compliance, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20855, USA.
N1 - Accession Number: 19992214371. Publication Type: Journal Article. Language: English. Number of References: 1 ref. Subject Subsets: Veterinary Science
KW - antidotes
KW - drug therapy
KW - drugs
KW - medicine
KW - poisoning
KW - reviews
KW - toxic substances
KW - veterinary medicine
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - medical sciences
KW - medicines
KW - pharmaceuticals
KW - poisons
KW - toxicosis
KW - Veterinary Profession (CC720) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - PCR-RFLP analysis of the coagulase gene of Staphylococcus aureus: application to the differentiation of epidemic and sporadic methicillin-resistant strains.
AU - Hookey, J. V.
AU - Edwards, V.
AU - Cookson, B. D.
AU - Richardson, J. F.
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
Y1 - 1999///
VL - 42
IS - 3
SP - 205
EP - 212
SN - 0195-6701
AD - Hookey, J. V.: Molecular Biology Unit, Virus Reference Laboratory, Central Public Health Service, Colindale, London NW9 5HT, UK.
N1 - Accession Number: 19992011912. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 61-32-5.
N2 - 140 isolates from 105 hospitals in England and Wales, representing 72 diverse phage types, were analysed by bacteriophage typing and PCR coagulase (coa) gene restriction fragment length polymorphism (RFLP). Isolates gave a coa gene PCR product that was either 660 base pairs (bp), 603 bp or 547 bp in size. The PCR products were digested with Alu I and Cfo I, and the fragments separated by gel electrophoresis. Eight coa gene RFLP patterns, numbered 1 to 8, were observed. Pattern 3 was most common (n=25 isolates), followed by patterns 2 and 5 (18 isolates each), pattern 1 (14 isolates), pattern 4 (11 isolates), pattern 7 (10 isolates), pattern 8 (8 isolates) and pattern 6 (6 isolates). Isolates of the same phage type often gave different coa gene RFLP patterns, and the patterns within the epidemic types EMRSA-03, EMRSA-15 and EMRSA-16 were heterogeneous. Therefore, representatives of EMRSA-03 were subtyped to coa RFLP patterns 1 and 2, those of EMRSA-05 to coa RFLP patterns 1, 2, 7 and 8, and those for EMRSA-16 to coa RFLP patterns 2, 3, 4, 5 and 6. It is suggested that the range of patterns within single phage types of S. aureus could help to discriminate between isolates/strains, and in a hierarchical approach coa gene RFLP could occupy an intermediate position between phage typing and pulsed-field gel electrophoresis (PFGE).
KW - bacterial diseases
KW - drug resistance
KW - epidemiology
KW - genes
KW - human diseases
KW - identification
KW - methicillin
KW - molecular epidemiology
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - techniques
KW - UK
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - PCR
KW - RFLP
KW - United Kingdom
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011912&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The efficacy of three common hospital liquid germicides to inactivate Cryptosporidium parvum oocysts.
AU - Wilson, J. A.
AU - Margolin, A. B.
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
Y1 - 1999///
VL - 42
IS - 3
SP - 231
EP - 237
SN - 0195-6701
AD - Wilson, J. A.: United States Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton Street, Winchester, MA 01890, USA.
N1 - Accession Number: 19990807101. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 111-30-8, 7553-56-2, 108-95-2, 9003-39-8. Subject Subsets: Protozoology
N2 - Three commonly used hospital disinfectants (a 10% phenol product, a 10% povidone [polyvidone]-iodine product and a 2.5% glutaraldehyde product) were tested against 3 concentrations of Cryptosporidium parvum oocysts (1.5 × 106, 1.5 × 105, 1.5 × 104) without organic load. In vitro excystation was used to determine viability and a cell culture assay was used to determine infectivity of germicide-treated oocysts. The 2.5% glutaraldehyde product was the most effective in halting excystation of sporozoites and infection in cell monolayers. However, this occurred only at the longest exposure time of 10 h and with the lowest concentration of oocysts (1.5 × 104). The other 2 products also decreased excystation, but were unable to halt infection. The ability of oocysts to remain viable and infectious after a 10 h treatment in glutaraldehyde is considered cause for concern in hospital disinfection units because endoscopic equipment that may come into contact with these organisms cannot be immersed into glutaraldehyde for this length of time due to its corrosive nature.
KW - disinfectants
KW - excystation
KW - glutaraldehyde
KW - infectivity
KW - iodine
KW - oocysts
KW - parasites
KW - phenol
KW - polyvidone
KW - viability
KW - Cryptosporidium parvum
KW - protozoa
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - crospovidone
KW - excystment
KW - polyvinylpyrrolidone
KW - povidone
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990807101&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changes in bacterial enzymes and PCR profiles of fecal bacteria from a patient with ulcerative colitis before and after antimicrobial treatments.
AU - Rafii, F.
AU - Embden, J. G. H. R. van
AU - Lieshout, L. M. C. van
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
Y1 - 1999///
VL - 44
IS - 3
SP - 637
EP - 642
SN - 0163-2116
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 19992006168. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 100680-33-9, 55268-75-2, 56238-63-2, 64544-07-6, 85721-33-1, 9007-49-2, 86386-73-4, 443-48-1, 15686-71-2.
N2 - A 26-year-old female patient, suffering from recurrent attacks of ulcerative colitis accompanied by extraintestinal symptoms (erythema nodosum and pyoderma gangrenosum), was evaluated for the effect of antibacterial agents on the intestinal bacteria and their enzymatic activities. The enzymes were assayed both at the onset of disease symptoms and after treatment with each of 5 drug regimens (fluconazole and cefadroxil, cefuroxime axetil and cestriaxone sodium, ciprofloxacin and cestriaxone sodium, ciprofloxacin alone, and ciprofloxacin, metronidazole, and cephalexin). The activities of azoreductase, nitroreductase, oxidoreductase, glucuronidase, and sulfatase were generally lower following all of the treatments, especially when ciprofloxacin was included. The DNA from each sample was amplified by PCR, using random primers. Profiles of amplified DNA on agarose gels showed different patterns, indicating differences in the microflora before and after the antimicrobial treatments. The clinical response to antibacterial therapy was consistent with the decreased bacterial enzymatic activities and changes in the microbial population. Ciprofloxacin, which was associated with the most dramatic falls in enzymatic activity, also had the best clinical results. It is concluded that intestinal bacteria and their enzymes play important roles in ulcerative colitis and that population changes can be monitored using PCR profiles.
KW - antibacterial agents
KW - case reports
KW - cefalexin
KW - cefuroxime
KW - ciprofloxacin
KW - DNA
KW - drug therapy
KW - enzymes
KW - fluconazole
KW - human diseases
KW - metronidazole
KW - oxidoreductases
KW - polymerase chain reaction
KW - sulfuric ester hydrolases
KW - ulcerative colitis
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - cefadroxil
KW - cephalexin
KW - cestriaxone
KW - chemotherapy
KW - deoxyribonucleic acid
KW - PCR
KW - redox enzymes
KW - sulfatases
KW - sulphatases
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992006168&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS.
AU - Holder, C. L.
AU - Churchwell, M. I.
AU - Doerge, D. R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 1999///
VL - 47
IS - 9
SP - 3764
EP - 3770
SN - 0021-8561
AD - Holder, C. L.: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 20001409324. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 486-66-8, 446-72-0. Subject Subsets: Human Nutrition; Soyabeans
N2 - Genistein is the principal soya isoflavone to which the putative beneficial effects of soya consumption have been attributed; however, the possibility of adverse biological effects (e.g. oestrogenic, antithyroid) has also been raised. This paper describes development and validation of a simple and sensitive analytical method for the determination of genistein in the blood of rats receiving dietary genistein (<0.5-1250 µg of genistein aglycone/g of chow). The method uses serum/plasma deproteination, liquid-liquid extraction, deuterated genistein and daidzein internal standards, isocratic LC separation, and electrospray mass spectrometric quantification using selected ion monitoring. Extraction efficiency is approximately 85%, the detection limits for genistein and daidzein from 50 µl of rat blood are approximately 5 nM, and the limit of quantification is approximately 15 nM. Interassay precision (relative standard deviation 4.5-4.6%) and intraassay precision (3.3-6.7%) were determined from replicate analysis of a spiked control and an incurred serum sample. The distribution of conjugated and unconjugated forms of genistein in the blood of rats was determined using selective enzyme hydrolysis. The glucuronide was the predominant metabolite (>90%), and only small amounts of the sulfate conjugate and the aglycone were observed at all dose levels. No evidence for additional metabolites was obtained. The 7- and 4′-glucuronide conjugates of genistein were identified using electrospray mass spectrometry and 1H NMR. Total blood genistein ranged from <15 nM in animals fed a soya-free control diet to as high as 8.9 µM in male rats fed 1250 µg of genistein/g chow and encompasses blood isoflavone levels observed in humans consuming a typical Asian diet and nutritional supplements (0.1-1 µM) and infants consuming soya formulae (2-7 µM).
KW - analytical methods
KW - blood
KW - daidzein
KW - determination
KW - diets
KW - genistein
KW - hydrolysis
KW - infants
KW - isoflavones
KW - mass spectrometry
KW - metabolites
KW - methodology
KW - monitoring
KW - soyabeans
KW - standards
KW - supplements
KW - techniques
KW - Glycine (Fabaceae)
KW - man
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Muridae
KW - rodents
KW - analytical techniques
KW - biochanin A
KW - methods
KW - soybeans
KW - surveillance systems
KW - Techniques and Methodology (ZZ900)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001409324&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dietary rosemary extract on cell-mediated immunity of young rats.
AU - Babu, U. S.
AU - Wiesenfeld, P. L.
AU - Jenkins, M. Y.
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
Y1 - 1999///
VL - 53
IS - 2
SP - 169
EP - 174
SN - 0921-9668
AD - Babu, U. S.: Division of Science and Applied Technology, Offices of Special Nutritionals and of Food Labeling, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 19991414060. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 9000-71-9. Subject Subsets: Human Nutrition
N2 - The impact of rosemary extract on splenic mononuclear cell proliferation was determined. Weanling male Sprague-Dawley rats were fed diets containing 0, 100, 200 or 400 mg/kg rosemary extract or 400 mg/kg butylated hydroxytoluene (BHT) in combination with 10 or 20% casein enriched diets for 8 weeks. Splenic mononuclear cells were isolated from these animals and mitogenic response to Concanavalin A (Con A), Phytohaemagglutinin (PHA) and lipopolysaccharide was determined. Con A and PHA-stimulated proliferation of spleen cells from rats fed 10% casein and 200 mg/kg rosemary extract was significantly higher than that of cells from the corresponding control animals. However, other levels of rosemary at 10% dietary casein or rosemary at any concentration fed along with 20% dietary casein had no impact on the mitogenic stimulation of splenic mononuclear cells. It is concluded that the use of rosemary may not have a generalized immuno-enhancing effect, and will probably be effective in some stressed conditions, such as protein or antioxidant deficiency.
KW - antioxidants
KW - casein
KW - cell division
KW - cell mediated immunity
KW - diet
KW - immunity
KW - lipopolysaccharides
KW - phytohaemagglutinins
KW - plant extracts
KW - rosemary
KW - spleen
KW - rats
KW - Rosmarinus officinalis
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rosmarinus
KW - Lamiaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - cellular immunity
KW - karyokinesis
KW - phytohemagglutinins
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991414060&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An overview from the Director of the Center for Food Safety and Applied Nutrition.
AU - Levitt, J. A.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 1999///
VL - 54
IS - 1
SP - 43
EP - 48
SN - 0015-6361
AD - Levitt, J. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA.
N1 - Accession Number: 20001407269. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The mission of the Food and Drug Administration's Center for Food Safety and Applied Nutrition is briefly reviewed.
KW - food safety
KW - nutrition
KW - nutrition research
KW - research institutes
KW - reviews
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - research establishments
KW - research institutions
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407269&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer.
AU - Ambrosone, C. B.
AU - Freudenheim, J. L.
AU - Thompson, P. A.
AU - Bowman, E.
AU - Vena, J. E.
AU - Marshall, J. R.
AU - Graham, S.
AU - Laughlin, R.
AU - Nemoto, L.
AU - Shields, P. G.
JO - Cancer Research (Baltimore)
JF - Cancer Research (Baltimore)
Y1 - 1999///
VL - 59
IS - 3
SP - 602
EP - 606
SN - 0008-5472
AD - Ambrosone, C. B.: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19991404764. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 50-81-7, 9054-89-1, 1406-18-4. Subject Subsets: Human Nutrition
N2 - It was hypothesized that: (i) the valine-to-alanine substitution in MnSOD that seems to alter transport of the enzyme into the mitochondrion, reducing its antioxidant efficacy, is associated with breast cancer risk; and (ii) that a diet rich in sources of antioxidants could ameliorate the effects on this risk. Data were collected in a case-control study of diet and breast cancer in western New York from 1986 to 1991. Caucasian women with incident, primary, histologically confirmed breast cancer were frequency-matched on age and county of residence to community controls. Blood specimens were collected and processed from a subset of participants in the study (266 cases and 295 controls). MnSOD genotypes were characterized in relation to breast cancer risk and the effect of the polymorphism on risk among low and high consumers of fruits and vegetables assessed. Premenopausal women who were homozygous for the A allele had a 4-fold increase in breast cancer risk in comparison to those with 1 or 2 V alleles (odds ratio, 4.3; 95% confidence interval (CI), 1.7-10.8). Risk was most pronounced among women below the median consumption of fruits and vegetables, dietary ascorbic acid and vitamin E, with little increased risk for those with diets rich in these foods. Relationships were weaker among postmenopausal women, although the MnSOD AA genotype was associated with an almost 2-fold increase in risk (odds ratio, 1.8; 95% CI, 0.9-3.6). No appreciable modification of risk by diet was detected for these older women. These data support the hypothesis that MnSOD and oxidative stress play a significant role in breast cancer risk, particularly in premenopausal women. The finding that risk was greatest among women who consumed lower amounts of dietary antioxidants and was minimal among high consumers indicates that a diet rich in sources of antioxidants may minimize the deleterious effects of the MnSOD polymorphism, thereby supporting public health recommendations for the consumption of diets rich in fruits and vegetables as a preventive measure against cancer.
KW - antioxidants
KW - ascorbic acid
KW - breast cancer
KW - diet
KW - diet studies
KW - enzyme activity
KW - fruit
KW - mammary gland neoplasms
KW - mutations
KW - neoplasms
KW - polymorphism
KW - superoxide dismutase
KW - vegetables
KW - vitamin E
KW - women
KW - New York
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - mammary tumour
KW - manganese superoxide dismutase
KW - United States of America
KW - vegetable crops
KW - vitamin C
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991404764&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposures to lead-based paint dust in an inner-city high school.
AU - Decker, J. A.
AU - Malkin, R.
AU - Kiefer, M.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 1999///
VL - 60
IS - 2
SP - 191
EP - 194
SN - 0002-8894
AD - Decker, J. A.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19992007622. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - In response to concerns about lead-based paint (LBP) in an 85-year old inner city high school in the eastern USA, an evaluation was conducted to determine whether a lead exposure hazard existed for adult school staff. Deteriorating LBP was present on walls and ceilings throughout the school. At the time of the evaluation, abatement of LBP had been completed in approximately one-third of the school. 118 wipe samples for lead dust were collected from floors, teachers' desks, and interior window sills. Areas selected for sampling were based on the work location of the 45 participants providing blood for lead analysis. Wipe samples from hands were collected from all participants. The geometric means (GMs) for lead dust loadings on sills in unabated rooms (n=23) and abated rooms (n=16) were 342 and 102 µg/ft², respectively. Nine sills in unabated rooms and one sill in an abated room exceeded the Housing and Urban Development (HUD) guidelines (500 µg/ft² lead) for residential housing following abatement activity. GMs for lead loadings on floors in unabated rooms (n=26) and abated rooms (n=14) were 136 and 70 µg/ft² lead, respectively. 17 floor samples from unabated rooms and 3 samples from abated rooms exceeded HUD guidelines (100 µg/ft² lead). The GM blood lead level (BLL) was 2.2 µg/100 ml (range: 0.6-5.6 µg/100 ml), similar to that of the general US population. Despite peeling LBP and significant lead dust loadings, a hazard from LBP was not found for staff at the school. There were no relationships between surface lead and hand lead, BLL and abatement status of assigned work area, or BLL and hand lead.
KW - blood
KW - buildings
KW - exposure
KW - floors
KW - lead
KW - paints
KW - personnel
KW - schools
KW - walls
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - flooring
KW - school buildings
KW - staff
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007622&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A mathematical model for simulating virus transport through synthetic barriers.
AU - Myers, M. R.
AU - Lytle, C. D.
AU - Routson, L. B.
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
Y1 - 1999///
VL - 61
IS - 1
SP - 113
EP - 140
SN - 0092-8240
AD - Myers, M. R.: Center for Devices and Radiological Health, U.S. FDA, HFZ-132, 12725 Twinbrook Parkway, Rockville, MD 20852, USA.
N1 - Accession Number: 19992007136. Publication Type: Journal Article. Language: English. Number of References: 25 ref.
KW - barriers
KW - disease transmission
KW - mathematical models
KW - transport
KW - viruses
KW - transportation
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992007136&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of Anisakis simplex in microwave-processed arrowtooth flounder (Atheresthes stomias).
AU - Adams, A. M.
AU - Miller, K. S.
AU - Wekell, M. M.
AU - Dong, F. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1999///
VL - 62
IS - 4
SP - 403
EP - 409
SN - 0362-028X
AD - Adams, A. M.: US Food and Drug Administration, Seafood Products Research Center, PO Box 3012, 22201 23rd Drive SE, Bothell, WA 98041-3012, USA.
N1 - Accession Number: 19990804641. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9001-75-6. Subject Subsets: Helminthology
N2 - A study was carried out to define the relationship between survival and temperature of Anisakis simplex in microwave-processed arrowtooth flounder (Atheresthes stomias). Ten fillets (each 126-467 g, 0.5 to 1.75 cm thick), with an average of 5 larvae of Anisakis simplex per fillet, were processed to target temperatures on high (100%) power using a commercial 700-W microwave oven. Fillets were neither covered nor rotated and had a temperature probe inserted to two-thirds depth into the thickest portion. After the fillet was digested using a 1% pepsin solution, the viability of nematodes was determined by viewing them under a dissecting microscope. Survival rates were 31% at 140°F (60°C), 11% at 150°F (65°C), 2% at 160°F (71°C), 3% at 165°F (74°C), and 0% at 170°F (77°C). Microwave processing of standardized fillet "sandwiches", 14 cm long, 4.5 cm wide, and approximately 1.75 cm high, each of which was preinoculated with 10 live nematodes, resulted in no survival at either 160°F or 170°F. Using ultraviolet light to detect both viable and non-viable nematodes in fillet sandwiches as an alternative method to pepsin digestion resulted in survival rates of 1% at 140°F (60°C), 3% at 145°F (63°C), and 0% at 150°F (65°C). Smaller fillet sandwiches, which most likely had fewer cold spots during microwave processing, required 150°F (65°C), whereas larger whole fillets required 170°F (77°C) to kill larvae of A. simplex. It is suggested that the parasites were most likely inactivated by a thermal mechanism of microwave treatment. Damage to the nematodes was often evident from ruptured cuticles that were no longer resistant to digestive enzymes.
KW - anisakiasis
KW - disease transmission
KW - foodborne diseases
KW - helminths
KW - microwave ovens
KW - parasites
KW - pepsin
KW - seafoods
KW - survival
KW - susceptibility
KW - temperature
KW - ultraviolet radiation
KW - viability
KW - Anisakis simplex
KW - Atheresthes
KW - fishes
KW - Nematoda
KW - Anisakis
KW - Anisakidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pleuronectidae
KW - Pleuronectiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Atheresthes
KW - Ascaridida
KW - Atheresthes stomias
KW - nematodes
KW - parasitic worms
KW - Secernentea
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990804641&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stability of tetracycline antibiotics in raw milk under laboratory storage conditions.
AU - Podhorniak, L. V.
AU - Leake, S.
AU - Schenck, F. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1999///
VL - 62
IS - 5
SP - 547
EP - 548
SN - 0362-028X
AD - Podhorniak, L. V.: U.S. Food and Drug Administration, Baltimore District Laboratory, 900 Madison Avenue, Baltimore, MD 21201, USA.
N1 - Accession Number: 19990403260. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Registry Number: 57-62-5, 64-72-2, 10118-90-8, 13614-98-7, 79-57-2, 60-54-8, 64-75-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - Raw milk samples, to which 50 p.p.b. each of chlortetracycline, demeclocycline, methacycline hydrochloride, minocycline, oxytetracycline and tetracycline had been added, were incubated at 4 or 25°C for up to 72 h, then analysed using a metal chelate affinity chromatography extraction and HPLC. No loss of tetracycline was observed after 48 h of storage at 4° or 24 h at 25°C. Losses ranging from 4 to 13% and from 0 to 18% were noted after 72 h at 4°C and 48 h at 25°C, respectively.
KW - antibiotic residues
KW - antibiotics
KW - chlortetracycline
KW - cold storage
KW - drug residues
KW - milk
KW - minocycline
KW - oxytetracycline
KW - stability
KW - storage
KW - temperature
KW - tetracycline
KW - tetracyclines
KW - achromycin
KW - aureomycin
KW - demeclocycline
KW - methacycline hydrochloride
KW - terramycin
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990403260&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An oligonucleotide-ligation assay for the differentiation between Cyclospora and Eimeria spp. polymerase chain reaction amplification products.
AU - Jinneman, K. C.
AU - Wetherington, J. H.
AU - Hill, W. E.
AU - Omiescinski, C. J.
AU - Adams, A. M.
AU - Johnson, J. M.
AU - Tenge, B. J.
AU - Dang, N. L.
AU - Wekell, M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1999///
VL - 62
IS - 6
SP - 682
EP - 685
SN - 0362-028X
AD - Jinneman, K. C.: Seafood Products Research Center, Food and Drug Administration, Bothell, WA 98041, USA.
N1 - Accession Number: 19990805661. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Protozoology
N2 - An oligonucleotide-ligation assay (OLA) was developed and compared to a restriction fragment length polymorphism (RFLP) test for distinguishing between 294-bp polymerase chain reaction (PCR) amplification products of the 18S rRNA gene from Cyclospora and Eimeria spp. The PCR/OLA correctly distinguished between 3 Cyclospora, 3 E. tenella and one E. mitis strains and the ratio of positive to negative spectrophotometric absorbance (A490) values for each strain ranged from 4.086 to 15.280 (median 9.5). PCR/OLA thus provides a rapid and reliable spectrophotometric alternative to PCR/RFLP.
KW - diagnosis
KW - differential diagnosis
KW - DNA amplification
KW - genes
KW - genetic polymorphism
KW - molecular genetics
KW - parasites
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - ribosomal RNA
KW - spectrophotometry
KW - strain differences
KW - strains
KW - Cyclospora
KW - Eimeria
KW - Eimeria mitis
KW - Eimeria tenella
KW - protozoa
KW - Eimeriidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Eimeria
KW - biochemical genetics
KW - PCR
KW - RFLP
KW - rRNA
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
KW - Animal Treatment and Diagnosis (Non Drug) (LL880) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.
AU - Kennelly, E. J.
AU - Flynn, T. J.
AU - Mazzola, E. P.
AU - Roach, J. A.
AU - McCloud, T. G.
AU - Danford, D. E.
AU - Betz, J. M.
JO - Journal of Natural Products
JF - Journal of Natural Products
Y1 - 1999///
VL - 62
IS - 10
SP - 1385
EP - 1389
SN - 0163-3864
AD - Kennelly, E. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street SW, Washington, D.C. 20204, USA.
N1 - Accession Number: 20000305162. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - The novel alkaloid thalictroidine, as well as the known alkaloids taspine, magnoflorine, anagyrine, baptifoline, 5,6-dehydro-α-isolupanine, α-isolupanine, lupanine, N-methylcytisine and sparteine, were identified from an extract of Caulophyllum thalictroides rhizomes. N-Methylcytisine exhibited teratogenic activity in the rat embryo culture (REC), an in vitro method to detect potential teratogens. The structure of thalictroidine was elucidated using various spectroscopic methods, primarily by NMR techniques. Thalictroidine, anagyrine, and α-isolupanine were not teratogenic in the REC at tested concentrations. Taspine showed high embryotoxicity, but no teratogenic activity, in the REC.
KW - alkaloids
KW - embryo culture
KW - embryos
KW - in vitro
KW - medicinal plants
KW - plant composition
KW - quinolizidine alkaloids
KW - rhizomes
KW - teratogens
KW - toxicity
KW - Berberidaceae
KW - rats
KW - Ranunculales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Berberidaceae
KW - Caulophyllum
KW - Caulophyllum thalictroides
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Plant Composition (FF040)
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Human Reproduction and Development (VV060)
KW - Animal Reproduction and Development (LL210) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of a commercial heat-shock process on Vibrio vulnificus in the American oyster, Crassostrea virginica, harvested from the Gulf Coast.
AU - Hesselman, D. M.
AU - Motes, M. L.
AU - Lewis, J. P.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 1999///
VL - 62
IS - 11
SP - 1266
EP - 1269
SN - 0362-028X
AD - Hesselman, D. M.: Charleston Resident Post, U.S. Food and Drug Administration, Charleston, South Carolina 29413, USA.
N1 - Accession Number: 20001407929. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - Oysters (Crassostrea virginica) harvested from the Gulf Coast, containing 10² to 104 most probable number (MPN) per gram of Vibrio vulnificus, were subjected to a commercial heat-shock process. After 1 to 4 min at internal oyster meat temperatures exceeding 50°C, shellstock oysters were shucked, chilled, washed, and packed. V. vulnificus and total bacterial levels in Gulf Coast oysters were significantly reduced from 1 to 4 logs in the finished product. Similar reductions were not observed in shellstock oysters that were subject to conventional processing. Under the National Shellfish Sanitation Programme, heat shocking is an acceptable process to use to assist in the shucking of shellstock.
KW - food processing
KW - foods
KW - heat shock
KW - microbial contamination
KW - oysters
KW - seasonal variation
KW - shellfish
KW - summer
KW - USA
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Processing (General) (QQ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001407929&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequencing of prototype viruses in the Venezuelan equine encephalitis antigenic complex.
AU - Meissner, J. D.
AU - Huang, C. Y. H.
AU - Pfeffer, M.
AU - Kinney, R. M.
JO - Virus Research
JF - Virus Research
Y1 - 1999///
VL - 64
IS - 1
SP - 43
EP - 59
SN - 0168-1702
AD - Meissner, J. D.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20000509551. Publication Type: Journal Article. Language: English. Number of References: 3 pp. of ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - The 5′ nontranslated region (5′NTR) and nonstructural region nucleotide sequences of nine enzootic Venezuelan equine encephalitis (VEE) virus strains were determined, thus completing the genomic RNA sequences of all prototype strains. The full-length genomes, representing VEE virus antigenic subtypes I-VI, range in size from 11.3 to 11.5 kilobases, with 48-53% overall G+C contents. Size disparities result from subtype-related differences in the number and length of direct repeats in the C-terminal nonstructural protein 3 (nsP3) domain coding sequence and the 3′NTR, while G+C content disparities are attributable to strain-specific variations in base composition at the wobble position of the polyprotein codons. Highly-conserved protein components and one nonconserved protein domain constitute the VEE virus replicase polyproteins. Approximately 80% of deduced nsP1 and nsP4 amino acid residues are invariant, compared to less than 20% of C-terminal nsP3 domain residues. In two enzootic strains, C-terminal nsP3 domain sequences degenerate into little more than repetitive serine-rich blocks. Nonstructural region sequence information drawn from a cross-section of VEE virus subtypes clarifies features of alphavirus conserved sequence elements and proteinase recognition signals. As well, whole-genome comparative analysis supports the reclassification of VEE subtype-variety IF and subtype II viruses.
KW - antigens
KW - molecular genetics
KW - nucleotide sequences
KW - Venezuelan equine encephalitis virus
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - biochemical genetics
KW - DNA sequences
KW - immunogens
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000509551&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oxidase-based DDT-pyrethroid cross-resistance in Guatemalan Anopheles albimanus.
AU - Brogdon, W. G.
AU - McAllister, J. C.
AU - Corwin, A. M.
AU - Cordon-Rosales, C.
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
Y1 - 1999///
VL - 64
IS - 2
SP - 101
EP - 111
SN - 0048-3575
AD - Brogdon, W. G.: Entomology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20000506912. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 50-29-3. Subject Subsets: Medical & Veterinary Entomology
N2 - A DDT-pyrethroid cross-resistant strain of A. albimanus was identified in Guatemala through bottle bioassays. Biochemical analysis found that the resistance was caused by an oxidase resistance mechanism. Only adult females expressed the oxidase mechanism, however in the parent strain, oxidase resistance coexisted with an elevated esterase level, an additional pyrethroid resistance mechanism.
KW - cross resistance
KW - DDT
KW - esterases
KW - females
KW - insecticide resistance
KW - organochlorine insecticides
KW - oxidoreductases
KW - pyrethroid insecticides
KW - pyrethroids
KW - resistance mechanisms
KW - Guatemala
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - dicophane
KW - mosquitoes
KW - redox enzymes
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic diversity within Cryptosporidium parvum and related Cryptosporidium species.
AU - Xiao LiHua
AU - Morgan, U. M.
AU - Limor, J.
AU - Escalante, A.
AU - Arrowood, M.
AU - Shulaw, W.
AU - Thompson, R. C. A.
AU - Fayer, R.
AU - Lal, A. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1999///
VL - 65
IS - 8
SP - 3386
EP - 3391
SN - 0099-2240
AD - Xiao LiHua: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20000805796. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Protozoology
N2 - To assess genetic diversity in Cryptosporidium parvum, the small subunit (SSU) rRNA gene was sequenced from 7 Cryptosporidium spp., various isolates of C. parvum from 8 hosts, and a Cryptosporidium isolate from a desert monitor (Varanus griseus). Phylogenetic analysis of the SSU rRNA sequences confirmed the multispecies nature of the genus Cryptosporidium, with at least 4 distinct species (C. parvum, C. baileyi, C. muris and C. serpentis). Other species previously defined by biological characteristics, including C. wrairi, C. meleagridis and C. felis, and the desert monitor isolate, clustered together or within C. parvum. Extensive genetic diversities were present among C. parvum isolates from humans, calves, pigs, dogs, mice, ferrets, marsupials and a rhesus monkey. Specific genotypes were associated with specific host species. A PCR-restriction fragment length polymorphism technique could differentiate most Cryptosporidium spp. and C. parvum genotypes, but sequence analysis of the PCR product was needed to differentiate C. wrairi and C. meleagridis from some of the C. parvum genotypes. The results indicate a need for taxonomic revision and an assessment of the zoonotic potential of some animal C. parvum isolates.
KW - calves
KW - domestic animals
KW - genes
KW - genetic variation
KW - genotypes
KW - host specificity
KW - molecular genetics
KW - molecular taxonomy
KW - nucleotide sequences
KW - parasites
KW - phylogeny
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - ribosomal RNA
KW - strains
KW - wild animals
KW - zoonoses
KW - cattle
KW - Cryptosporidium
KW - Cryptosporidium baileyi
KW - Cryptosporidium muris
KW - Cryptosporidium parvum
KW - dogs
KW - ferrets
KW - lizards
KW - man
KW - marsupials
KW - mice
KW - monkeys
KW - pigs
KW - protozoa
KW - Varanus
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Cryptosporidium
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Mustela
KW - Mustelidae
KW - Sauria
KW - reptiles
KW - Homo
KW - Hominidae
KW - Primates
KW - Muridae
KW - rodents
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Varanidae
KW - Varanus
KW - biochemical genetics
KW - Cryptosporidium felis
KW - Cryptosporidium meleagridis
KW - Cryptosporidium serpentis
KW - Cryptosporidium wrairi
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - hogs
KW - PCR
KW - RFLP
KW - rRNA
KW - swine
KW - Varanus griseus
KW - zoonotic infections
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perkinsus marinus extracellular protease modulates survival of Vibrio vulnificus in eastern oyster (Crassostrea virginica) hemocytes.
AU - Tall, B. D.
AU - Peyre, J. F. la
AU - Bier, J. W.
AU - Miliotis, M. D.
AU - Hanes, D. E.
AU - Kothary, M. H.
AU - Shah, D. B.
AU - Faisal, M.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 1999///
VL - 65
IS - 9
SP - 4261
EP - 4263
SN - 0099-2240
AD - Tall, B. D.: Division of Microbiological Studies (HFS-517), Food and Drug Administration, 200 C St. S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 20000806196. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology; Human Nutrition
N2 - The in vitro effects of the Perkinsus marinus serine protease on the uptake and intracellular survival of the human pathogen Vibrio vulnificus in oyster (Crassostrea virginica) haemocytes were examined by using a time-course gentamicin internalization assay. Protease-treated haemocytes were initially slower to internalize V. vulnificus than untreated haemocytes (P<0.05). After 1 hour, the elimination of V. vulnificus by treated haemocytes was significantly suppressed compared with elimination by untreated haemocytes (treated haemocytes contained more than 5 times as many V. vulnificus as untreated ones - P<0.05) or elimination of invasive and noninvasive control bacteria. It is concluded that the serine protease produced by P. marinus suppresses the vibriocidal activity of oyster haemocytes which would otherwise tend to eliminate V. vulnificus, potentially leading to conditions favouring higher numbers of vibrios in oyster tissues.
KW - foodborne diseases
KW - haemocytes
KW - in vitro
KW - interactions
KW - oysters
KW - parasites
KW - pathogens
KW - pathology
KW - serine proteinases
KW - shellfish
KW - Crassostrea virginica
KW - Perkinsus marinus
KW - protozoa
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Crassostrea
KW - Ostreidae
KW - Perkinsus
KW - Perkinsidae
KW - Perkinsorida
KW - Apicomplexa
KW - Protozoa
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - hemocytes
KW - serine proteases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Aquatic Biology and Ecology (MM300)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HPLC analysis for trans-vitamin K1 and dihydro-vitamin K1 in margarines and margarine-like products using the C30 stationary phase.
AU - Cook, K. K.
AU - Mitchell, G. V.
AU - Grundel, E.
AU - Rader, J. I.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 1999///
VL - 67
IS - 1
SP - 79
EP - 88
SN - 0308-8146
AD - Cook, K. K.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 19991411664. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 8001-22-7, 8001-21-6, 12001-79-5. Subject Subsets: Human Nutrition; Soyabeans
N2 - A C30 column successfully separated the cis and trans isomers of vitamin K1 in margarines, reduced-fat margarine-like products and in their ingredient oils. The compound 2′3′-dihydro-vitamin K1, a derivative formed during hydrogenation of oils containing vitamin K1 was also measured. An enzymatic procedure, currently under AOAC collaborative study for milk and infant formulas was compared with a more direct extraction method in analysing margarines and margarine-like products. Both methods have good precision and were applicable to the majority of products examined. Margarines or margarine-like products identifying liquid soyabean oil, hydrogenated soyabean oil or liquid rapeseed oil as their primary ingredients contained about 50-160 µg vitamin K1/100 g. Blends of sunflower and soyabean oils contained <50 µg vitamin K1/100 g. Hardened or "stick" margarines contained more 2′3′-dihydro-vitamin K1 than "soft" or "tub" products (122-285 µg/100 g vs. 38-131 µg/100 g, respectively). Eight of 18 products (44%) contained 10% or more of the reference daily intake for vitamin K1 per serving. Higher-fat margarines contained more vitamin K1 than their lower-fat counterparts.
KW - analytical methods
KW - characterization
KW - composition
KW - HPLC
KW - isomers
KW - maize oil
KW - margarine
KW - plant oils
KW - rapeseed oil
KW - soyabean oil
KW - sunflower oil
KW - vitamin K
KW - analytical techniques
KW - corn oil
KW - high performance liquid chromatography
KW - soybean oil
KW - vegetable oils
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991411664&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Conformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope.
AU - Gilmore, R. D., Jr.
AU - Mbow, M. L.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 1999///
VL - 67
IS - 10
SP - 5463
EP - 5469
SN - 0019-9567
AD - Gilmore, R. D., Jr.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Foothills Campus, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20000503158. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The results of tick bite challenges to groups of mice actively immunized with strain B31-derived recombinant outer surface protein C (OspC) that had been treated by heat and chemical denaturation procedures were studied. Following seroconversion to OspC, the animals were challenged with an infectious dose of B. burgdorferi B31 by Ixodes scapularis bite. Whereas mice immunized with a soluble, nondenatured form continued to show protection rates close to 100%, mice that had been immunized with denatured antigen were not protected. Furthermore, mice that were immunized with an insoluble (rather than a soluble), nondenatured form of the recombinant OspC showed a protection rate of only 40%. Protective epitope localization experiments showed that either the amino or the carboxy end of the recombinant protein was required to react with a protective OspC-specific monoclonal antibody. It is concluded that a conformational organization of the protein is essential for the protective capability of the strain B31 OspC immunogen.
KW - antigens
KW - conformation
KW - denaturation
KW - DNA cloning
KW - gene expression
KW - immunity
KW - immunization
KW - laboratory animals
KW - protection
KW - seroconversion
KW - solubility
KW - strains
KW - surface proteins
KW - tickborne diseases
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - mice
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - antigenicity
KW - bacterium
KW - body conformation
KW - immune sensitization
KW - immunogens
KW - membrane proteins
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000503158&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health claims and observational human data: relation between dietary fat and cancer.
AU - Lewis, C. J.
AU - Yetley, E. A.
A2 - Byers, T.
A2 - Dickson, J. H.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1999///
VL - 69
IS - 6
SP - 1357S
EP - 1364S
SN - 0002-9165
AD - Lewis, C. J.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC, USA.
N1 - Accession Number: 19991410691. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration approval of food-label health claims linking the risk of cancer with dietary fat intake is discussed in the context of considerations in the use of epidemiologic evidence, observational data in particular to support dietary recommendations.
KW - consumption
KW - diet studies
KW - dietary fat
KW - dietary guidelines
KW - epidemiology
KW - fat consumption
KW - fats
KW - food legislation
KW - labelling
KW - neoplasms
KW - reviews
KW - cancers
KW - labeling
KW - labels
KW - source fat
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410691&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use.
AU - Lewis, C. J.
AU - Crane, N. T.
AU - Wilson, D. B.
AU - Yetley, E. A.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1999///
VL - 70
IS - 2
SP - 198
EP - 207
SN - 0002-9165
AD - Lewis, C. J.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC, USA.
N1 - Accession Number: 19991413877. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
N2 - Two national food consumption surveys in the US were updated to reflect folate intakes as a result of the recently initiated food fortification programme and to correct folate intakes for the apparently higher bioavailability of synthetic folic acid (SFA; ie, folate added to foods or from dietary supplements) than of naturally occurring folate so as to express intakes as dietary folate equivalents. It was not possible to chemically analyse foods, so adjustments were made to food-composition data by using information about food ingredients and characteristics. Total folate intakes were estimated for several sex and age groups using the modified data coupled with dietary supplement use. Within the limitations of the data, 67-95% of the population met or surpassed the new estimated average requirement, depending on the sex and age group and survey. Nonetheless, some subgroups had estimated intakes below these standards. Estimated SFA intakes suggested that ~15-25% of children aged 1-8 years, depending on the survey, had intakes above the newly established tolerable upper intake level. 68-87% of females of childbearing age had SFA intakes below the recommended intake of 400 µg/d, depending on the age group and survey. It is concluded that there is a need to explore ways to improve folate intakes in targeted subgroups, including females of childbearing age, while not putting other population groups at risk of excessive intakes.
KW - children
KW - diet studies
KW - diets
KW - folic acid
KW - food consumption
KW - food safety
KW - foods
KW - intake
KW - supplements
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - folacin
KW - folate
KW - United States of America
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413877&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
AU - James, S. J.
AU - Pogribna, M.
AU - Pogribny, I. P.
AU - Melnyk, S.
AU - Hine, R. J.
AU - Gibson, J. B.
AU - Yi Ping
AU - Tafoya, D. L.
AU - Swenson, D. H.
AU - Wilson, V. L.
AU - Gaylor, D. W.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 1999///
VL - 70
IS - 4
SP - 495
EP - 501
SN - 0002-9165
AD - James, S. J.: National Center for Toxicological Research, Division of Biochemical Toxicology, HFT 140, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20001406666. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 59-30-3, 6027-13-0, 63-68-3. Subject Subsets: Human Nutrition
N2 - The frequency of the methylenetetrahydrofolate reductase (MTHFR) 677C->T mutation was evaluated in 57 mothers of children with Down syndrome and in 50 age-matched control mothers. Ratios of plasma homocysteine to methionine and lymphocyte methotrexate cytotoxicity were measured as indicators of functional folate status. A significant increase in plasma homocysteine concentrations and lymphocyte methotrexate cytotoxicity was observed in the mothers of children with Down syndrome, consistent with abnormal folate and methyl metabolism. Mothers with the 677C->T mutation had a 2.6-fold higher risk of having a child with Down syndrome than did mothers without the T substitution (odds ratio: 2.6; 95% CI: 1.2, 5.8; P<0.03). It is concluded that folate metabolism is abnormal in mothers of children with Down syndrome and that this may be explained, in part, by a mutation in the MTHFR gene.
KW - children
KW - congenital abnormalities
KW - cytotoxicity
KW - Down's syndrome
KW - folic acid
KW - genes
KW - homocysteine
KW - lymphocytes
KW - metabolism
KW - methionine
KW - mothers
KW - mutations
KW - risk factors
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth defects
KW - congenital malformations
KW - folacin
KW - folate
KW - mongolism
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406666&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tandem-in-time mass spectrometry method for the sub-parts-per-trillion determination of 2,3,7,8-chlorine-substituted dibenzo-p-dioxins and -furans in high-fat foods.
AU - Hayward, D. G.
AU - Hooper, K.
AU - Andrzejewski, D.
JO - Analytical Chemistry (Washington)
JF - Analytical Chemistry (Washington)
Y1 - 1999///
VL - 71
IS - 1
SP - 212
EP - 220
SN - 0003-2700
AD - Hayward, D. G.: US Food and Drug Administration, 200 C Street SW, Washington, D.C. 20204, USA.
N1 - Accession Number: 19991403362. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition; Poultry; Dairy Science
N2 - Limits of quantitation (LOQ) for a quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) method were evaluated through replicate analysis of unfortified peanut [groundnut] oil, shortening, lamb fat and butter for all 2,3,7,8-chlorine-substituted polychlorodibenzo-p-dioxins (PCDD) and polychlorodibenzofurans (PCDF). 10 congeners were measurable in butter (0.27-2.5 pg/g) and 9 congeners in lamb fat (0.09-2.6 pg/g) with good precision. LOQ for high-fat foods were estimated by triplicate analysis of peanut oil fortified at 2 levels. Accurate and reproducible results were achieved at 0.5 pg/g for most PCDD/PCDF (1.0 pg/g for heptachlorodibenzo-p-dioxin and heptachlorodibenzofuran and 2.0 pg/g for octachlorodibenzofuran) and at 0.2 pg/g for 2,3,7,8-tetrachlorodibenzofuran (TCDF) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). QISTMS distinguished between catfish and chicken eggs with elevated TCDD levels from background samples collected from most regions of the USA. QISTMS determined the extent of TCDD contamination in butter, lamb fat and cottonseed oil collected from rural villages in Kazakhstan. Replicate analysis of catfish and chicken eggs by the QISTMS method produced comparable results to high-resolution mass spectrometry (HRMS). It is concluded that lower limits of detection will be needed if QISTMS is to fully complement HRMS in the measurement of TCDD levels in food.
KW - analytical methods
KW - animal fat
KW - animal products
KW - butter
KW - carcinogens
KW - chemicals
KW - contaminants
KW - contamination
KW - cottonseed oil
KW - dioxins
KW - eggs
KW - fish
KW - food contamination
KW - furans
KW - heterocyclic oxygen compounds
KW - lamb (meat)
KW - meat products
KW - milk products
KW - plant oils
KW - plant products
KW - poultry
KW - spectrometry
KW - toxic substances
KW - USA
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - chickens
KW - crop products
KW - dairy products
KW - domesticated birds
KW - food contaminants
KW - poisons
KW - United States of America
KW - vegetable oils
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Pollution and Degradation (PP600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403362&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food safety in the 21st century.
AU - Käferstein, F.
AU - Abdussalam, M.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1999///
VL - 77
IS - 4
SP - 347
EP - 351
SN - 0042-9686
AD - Käferstein, F.: Food and Drug Administration, and the Food Safety and Inspection Service, Joint Institute for Food Safety and Applied Nutrition, 200 C Street S.W. HFS-6, Washington, DC 20204-0001, USA.
N1 - Accession Number: 19991408521. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
KW - cholera
KW - diarrhoea
KW - epidemiology
KW - food policy
KW - food safety
KW - health
KW - hepatitis
KW - reviews
KW - salmonellosis
KW - urbanization
KW - world
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - diarrhea
KW - E. coli
KW - Salmonella infections
KW - scouring
KW - worldwide
KW - Human Nutrition (General) (VV100)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991408521&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oral iodine supplementation does not reduce neutralizing antibody responses to oral poliovirus vaccine.
AU - Taffs, R. E.
AU - Enterline, J. C.
AU - Rusmil, K.
AU - Muhilal
AU - Suwardi, S. S.
AU - Rustama, D.
AU - Djatnika
AU - Cobra, C.
AU - Semba, R. D.
AU - Cohen, N.
AU - Asher, D. M.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 1999///
VL - 77
IS - 6
SP - 484
EP - 491
SN - 0042-9686
AD - Taffs, R. E.: Laboratory of Method Development, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA.
N1 - Accession Number: 19992009881. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 25 ref. Registry Number: 7553-56-2. Subject Subsets: Tropical Diseases; Human Nutrition
N2 - A randomized, double-blind, placebo-controlled clinical trial was conducted in Subang, West Java, Indonesia, in which 617 eight-week-old infants received either oral iodized oil (OIO) or a placebo (poppy-seed oil) during a routine visit for their first dose of oral poliovirus vaccine (OPV) as part of the Expanded Programme on Immunization (EPI). The infants received 2 boosters of OPV at 4-week intervals after the first dose, and were followed up when 6 months old. Neutralizing antibody titres to poliovirus serotypes 1, 2, and 3 were compared in serum samples that were taken from 478 of these infants just before the first dose of OPV and at 6 months. It was found that oral iodized oil did not reduce the antibody responses to any of the 3 serotypes of OPV. These results indicate that oral iodine may safely be delivered to infants at the same time as oral poliovirus vaccine according to current EPI immunization schedules.
KW - human diseases
KW - immune response
KW - immunity
KW - immunization
KW - infants
KW - iodine
KW - neutralizing antibodies
KW - supplements
KW - vaccination
KW - Indonesia
KW - Java
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Indonesia
KW - human poliovirus
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - iodized oil
KW - Jawa
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009881&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oxytetracycline transfer into chicken egg yolk or albumen.
AU - Donoghue, D. J.
AU - Hairston, H.
JO - Poultry Science
JF - Poultry Science
Y1 - 1999///
VL - 78
IS - 3
SP - 343
EP - 345
SN - 0032-5791
AD - Donoghue, D. J.: Division of Animal Research, Center for Veterinary Medicine, Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
N1 - Accession Number: 19992207503. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 79-57-2, 9006-50-2. Subject Subsets: Veterinary Science; Animal Nutrition; Veterinary Science; Poultry
N2 - This study was conducted to determine whether the approved doses of oxytetracycline (OTC) for breeder hens and meat-type poultry would produce drug residue transfer into egg components when fed to laying hens. Two groups of 10 hens were fed either 50 or 200 g/ton OTC for 5 days. Oxytetracycline concentrations in egg components were determined daily during a 2-day pretreatment control period, the 5-day dosing period, and following drug withdrawal. The stability and drug content of the medicated feed were determined the day dosing was started and the day of withdrawal. Residues of OTC were not detectable during the pre-dosing, dosing, or withdrawal period in egg yolks. Oxytetracycline residues were detectable, however, in egg albumen during the 5th day of treatment and the 1st day of medicated feed withdrawal. These concentrations were close to the limit of the assay sensitivity (117 ppb). It is concluded that illegal or unintentional dosing of laying hens with feed medicated at the doses allowed for breeder hens or meat-type poultry should not produce consistently detectable levels of residues of OTC in eggs.
KW - animal experiments
KW - antibiotic residues
KW - antibiotics
KW - drug residues
KW - egg albumen
KW - egg yolk
KW - eggs
KW - hens
KW - medicated feeds
KW - oxytetracycline
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal research
KW - chickens
KW - domesticated birds
KW - egg white
KW - terramycin
KW - yolk
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Eggs and Egg Products (QQ040)
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Meat Produce (QQ030)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992207503&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Propelling novel vaccines directed against tuberculosis through the regulatory process.
AU - Brennan, M. J.
AU - Collins, F. M.
AU - Morris, S. L.
JO - Tubercle and Lung Disease
JF - Tubercle and Lung Disease
Y1 - 1999///
VL - 79
IS - 3
SP - 145
EP - 151
SN - 0962-8479
AD - Brennan, M. J.: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville MD, USA.
N1 - Accession Number: 19992011522. Publication Type: Journal Article. Language: English. Number of References: 44 ref.
N2 - The development of novel vaccines for use in the prevention and immunotherapy of tuberculosis is an area of intense interest for scientific researchers, public health agencies and pharmaceutical manufacturers. Development of effective anti-tuberculosis vaccines for use in specific target populations will require close cooperation among several different international organizations including agencies responsible for evaluating the safety and effectiveness of new biologics for human use. In this review, the major issues that are addressed by regulatory agencies to ensure that vaccines are pure, potent, safe, and effective are discussed. It is hoped that the comments provided here will help accelerate the development of new effective vaccines for the prevention and treatment of tuberculosis.
KW - clinical trials
KW - human diseases
KW - reviews
KW - tuberculosis
KW - vaccine development
KW - vaccines
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - regulatory agencies
KW - Health Services (UU350)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011522&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quality control and safety of animal products.
AU - Miller, M. A.
JO - Canadian Journal of Animal Science
JF - Canadian Journal of Animal Science
Y1 - 1999///
VL - 79
IS - 4
SP - 533
EP - 538
SN - 0008-3984
AD - Miller, M. A.: Human Food Safety and Consultative Services, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, US Food and Drug Administration, Rockville, MD 20857, USA.
N1 - Accession Number: 20002211928. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 13 ref. Subject Subsets: Veterinary Science; Human Nutrition
N2 - This paper discusses the animal drug approval process regulated by the Center for Veterinary Medicine (CVM), Food and Drug Administration (FDA) of the USA. The CVM of FDA considers 2 criteria in ensuring the human food safety of edible animal products: (i) safety of the chemical residues and (ii) for antimicrobial products, microbiological safety including changes in bacterial pathogen load and resistance pattern. The hazard associated with animal drug products of non-carcinogenic compounds is assessed by conducting a standard battery of toxicology test, whereas the hazard from the carcinogenic potential of compounds is evaluated based on structure, results of genetic toxicity tests and toxicology studies. Post approval monitoring is carried out to ensure that the animal drugs are being used properly after their approval. Particular concern is given to those eliciting an "acute" toxic reaction at relatively low levels. The other aspect of food safety regulated by CVM of FDA is microbiological safety, especially to antimicrobial drugs used at subtherapeutic levels in feeds. The studies are designed by FDA to ensure that antibiotic treatment of food-producing animals does not alter pathogen load or resistance pattern of pathogens. Two studies are generally performed: (i) the salmonella shedding study, which addresses the effect of drug treatment on the excretion of salmonella in the faeces of animals artificially infected with salmonella; and (ii) the coliform resistance study, which monitors the effect of the drug on the resistance pattern of Escherichia coli present in the endogenous faecal flora. After a retrospective study of the microbiological safety over the past 20 years, CVM is planning to revise some microbiological safety studies with focuses on: (i) pathogen load, pathogen excretion and microorganism resistance pattern at the time of slaughter; and (ii) susceptibility studies on products that have utility in human medicine.
KW - animal products
KW - antibiotics
KW - approval schemes
KW - coliform bacteria
KW - drug residues
KW - drugs
KW - food safety
KW - microbiology
KW - quality controls
KW - regulations
KW - safety
KW - toxicology
KW - USA
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - medicines
KW - pharmaceuticals
KW - quality assurance
KW - rules
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Laws and Regulations (DD500)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002211928&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Key environmental human health issues in the Great Lakes and St. Lawrence River basins.
AU - Johnson, B. L.
AU - Hicks, H. E.
AU - Rosa, C. T. de
A2 - Rosa, C. T. de
A2 - Gilman, A. P.
A2 - Rosemond, Z. A.
JO - Environmental Research, Section A
JF - Environmental Research, Section A
Y1 - 1999///
VL - 80
IS - 2
SP - S2
EP - S12
AD - Johnson, B. L.: Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
N1 - Accession Number: 19991405262. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 57 ref. Subject Subsets: Human Nutrition
N2 - A summary is presented of the key findings and issues raised in the 1997 Health Conference on the effects of the environment on human health in the Great Lakes and St. Lawrence River basins, held in Montreal, Québec, Canada on May 12-15, 1997.
KW - fish
KW - food contamination
KW - human fertility
KW - lakes
KW - organochlorine compounds
KW - pesticides
KW - pollution
KW - public health
KW - reviews
KW - rivers
KW - toxicity
KW - water pollution
KW - Canada
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - environmental pollution
KW - food contaminants
KW - organic chlorine compounds
KW - United States of America
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Pollution and Degradation (PP600)
KW - Freshwater and Brackish Water (PP210) (Discontinued March 2000)
KW - Diet Studies (VV110)
KW - Human Reproduction and Development (VV060)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991405262&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and survey of ochratoxin A in wheat, barley, and coffee - 1997.
AU - Trucksess, M. W.
AU - Giler, J.
AU - Young, K.
AU - White, K. D.
AU - Page, S. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 1
SP - 85
EP - 89
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19991200970. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Horticultural Science; Medical & Veterinary Mycology; Wheat, Barley & Triticale Abstracts; Postharvest Research
N2 - A modified liquid chromatographic (LC) method for determining ochratoxin A (OA) in green coffee was applied to wheat, barley, green coffee and roasted coffee imported into the USA. The test sample was extracted with methanol-1% NaHCO3 (7+3), and the extract was filtered. The filtrate was diluted with phosphate-buffered saline (PBS), filtered and passed through an immunoaffinity column. After the column was washed with PBS and then with water, OA was eluted with methanol. The eluate was evaporated to dryness, and the residue was dissolved in acetonitrile-water (1+1). OA was separated on a reversed-phase C18 LC column with acetonitrile-water-acetic acid (55+45+1) as eluant and quantitated with a fluorescence detector. Recoveries of OA from the 4 commodities spiked over the range 1-4 ng/g were 71-96%. The limit of detection was approx. 0.03 ng/g. OA contamination at >0.03 ng/g was found in 56 of 383 wheat samples, 11 of 103 barley samples, 9 of 19 green coffee samples and 9 of 13 roasted coffee samples. None of the coffee samples contained OA at >5 ng/g; only 4 samples of wheat and 1 sample of barley were contaminated above this level.
KW - barley
KW - coffee
KW - contamination
KW - detection
KW - ochratoxins
KW - surveys
KW - wheat
KW - USA
KW - Coffea
KW - Hordeum vulgare
KW - Triticum
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Hordeum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991200970&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preparative method for isolating α-zearalenol and zearalenone using extracting disk.
AU - Ware, G. M.
AU - Zhao YuHong
AU - Kuan, S. S.
AU - Carman, A. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 1
SP - 90
EP - 94
SN - 1060-3271
AD - Ware, G. M.: U.S. Food and Drug Administration, Natural Toxins Research Center, New Orleans, LA 70122, USA.
N1 - Accession Number: 19991200971. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 5916-52-9, 17924-92-4. Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology; Maize; Postharvest Research
N2 - A liquid chromatographic method is described for the determination of zearalenol and zearalenone in corn [maize]. Zearalenol and zearalenone are extracted from maize with methanol-water (1+1) and cleaned-up using a solid-phase extraction (SPE) disc, separated on a reversed-phase analytical column, and detected with a fluorescence detector. The SPE disc concentrated and cleanly separated zearalenol and zearalenone from sample interferences. Standard calibration curves for zearalenol and zearalenone for the concentration range 25-500 ng/ml were linear. The small extract disc had a column capacity equivalent to 1 g extracted maize. Zearalenol and zearalenone were added at levels ranging from 10 to 2000 ng/g to a control sample that contained no detectable levels of zearalenol and zearalenone. Both toxins were recovered from spiked samples at 106.3 and 103.8%, with coefficients of variation of 7.6 and 13.0%, respectively. The method has an estimated reliable limit of detection and limit of quantitation around 10 and 40 ng/g for each toxin, respectively.
KW - analytical methods
KW - contamination
KW - detection
KW - liquid chromatography
KW - maize
KW - zearalenol
KW - zearalenone
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - corn
KW - f-2 toxin
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biodeterioration, Storage Problems and Pests of Feed (RR111) (Discontinued March 2000)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A liquid chromatographic method for analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in medical food using matrix solid-phase dispersion in conjunction with a zero reference material as a method development tool.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 1
SP - 107
EP - 111
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19991403511. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic method is described for analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in medical food. The vitamins are extracted from medical food without saponification by matrix solid-phase dispersion and chromatographed by normal-phase chromatography with fluorescence detection. Retinyl palmitate and all-rac-α-tocopheryl acetate are quantitated isocratically with a mobile phase of 0.125% (v/v) and 0.5% (v/v) isopropyl alcohol in hexane, respectively. Results compared favourably with label declarations on retail medical foods. Recoveries determined on an analyte-fortified zero reference material for a milk-based medical food averaged 98.3% (n=25) for retinyl palmitate spikes and 95.7% (n=25) for all-rac-α-tocopheryl acetate spikes. Five concentrations were examined for each analyte, and results were linear (r²=0.995 for retinyl palmitate and 0.9998 for all-rac-α-tocopheryl acetate) over the concentration range examined, with coefficients of variation in the range 0.81-4.22%. The method provides a rapid, specific, and easily controlled assay for analysis of retinyl palmitate and all-rac-α-tocopheryl acetate in fortified medical foods.
KW - analytical methods
KW - fortification
KW - liquid chromatography
KW - retinol
KW - retinyl palmitate
KW - vitamin E
KW - vitamin E acetate
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - retinol palmitate
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991403511&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in medical foods using a zero control reference material (ZRM) as a method development tool.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 2
SP - 271
EP - 275
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19991406746. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic method is described for analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in medical food. The vitamins are extracted in isopropyl alcohol and hexane-ethyl acetate without saponification and quantitated by normal-phase chromatography with fluorescence detection. All-rac-α-tocopheryl acetate and retinyl palmitate are chromatographed isocratically with a mobile phase of 0.5% (v/v) and 0.125% (v/v) isopropyl alcohol in hexane, respectively. Recovery studies performed on a medical food zero control reference material (ZRM) fortified with the analytes averaged 99.7% (n=25) for retinyl palmitate and 101% (n=25) for all-rac-α-tocopheryl acetate. Coefficients of variation were 0.87-2.63% for retinyl palmitate and 1.42-3.20% for all-rac-α-tocopheryl acetate. The method provides a rapid, specific, and easily controlled assay for analysis of vitamin A and vitamin E in medical foods. Use of chlorinated solvents is avoided.
KW - analytical methods
KW - chromatography
KW - foods
KW - retinol
KW - retinyl palmitate
KW - vitamin E
KW - vitamin E acetate
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - retinol palmitate
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991406746&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of β-carotene in medical food by liquid chromatography with matrix solid-phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 3
SP - 663
EP - 665
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19991409749. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 7235-40-7. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic method is described for analysis of β-carotene in medical food. The nutrient is extracted from medical food without saponification by matrix solid-phase dispersion and quantitated by isocratic normal-phase chromatography with a Si 60 column and a mobile phase of hexane containing 0.125% (v/v) isopropyl alcohol. The limit of quantitation is 0.02 µg/ml at 436 nm. Standard response was linear over the concentration range of 0.02-1.0 µg/ml (r² = 0.99998). Recoveries were determined on a zero control reference material containing added β-carotene at various levels. Recoveries averaged 91.2% (n=25) with coefficients of variation from 0.50 to 3.10%. The method provides a rapid, specific, sensitive, and easily controlled assay for analysis of β-carotene in fortified medical food. In addition, retinyl palmitate can be assayed simultaneously with an in-line fluorescence detector.
KW - analytical methods
KW - beta-carotene
KW - enteral feeding
KW - liquid chromatography
KW - therapeutic diets
KW - analytical techniques
KW - diet therapy
KW - special diets
KW - therapeutic nutrition
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409749&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measurement of sugars and starches in foods by a modification of the AOAC total dietary fiber method.
AU - Casterline, J. L., Jr.
AU - Oles, C. J.
AU - Ku Yuoh
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 3
SP - 759
EP - 765
SN - 1060-3271
AD - Casterline, J. L., Jr.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Science and Applied Technology, Office of Food Labeling, 200 C St, SW, Washington ,DC 20204, USA.
N1 - Accession Number: 19991409750. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 57-48-7, 50-99-7, 62-42-3, 69-79-4, 9005-25-8, 57-50-1. Subject Subsets: Human Nutrition; Dairy Science
N2 - A separation scheme for the estimation of sugars and starch in processed food was developed. It was based on the Association of Official Analytical Chemists (AOAC) Method 985.29 for total dietary fibre with these modifications: carbohydrate starches are separated into soluble and insoluble fractions before they are hydrolysed; acetonitrile was used instead of ethanol to separate sugars from enzyme-resistant carbohydrates, proteins, and other macromolecules; and a solid-phase extraction filter was included to remove substances that interfere with HPLC. Recovery studies indicate a >97% sugar recovery. Twenty foods were analysed. After enzymic hydrolysis, fructose, glucose, sucrose, maltose and lactose were extracted and determined by HPLC using a refractive index detector. Starch content was calculated from the increase in the amount of glucose. The results were compared with values listed on the Nutrition Facts panel for that food. The analysed amounts of sugars and starches were 73-96% of declared values.
KW - analytical methods
KW - carbohydrates
KW - foods
KW - fructose
KW - glucose
KW - HPLC
KW - lactose
KW - maltose
KW - processed products
KW - starch
KW - sucrose
KW - sugars
KW - analytical techniques
KW - dextrose
KW - fruit sugar
KW - high performance liquid chromatography
KW - ketohexose
KW - laevulose
KW - levulose
KW - milk sugar
KW - saccharides
KW - saccharose
KW - Techniques and Methodology (ZZ900)
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409750&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of azaperone and its metabolically reduced form, azaperol, in swine liver by gas chromatography/mass spectrometry.
AU - Adam, L. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 4
SP - 815
EP - 824
SN - 1060-3271
AD - Adam, L. A.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance of Compliance, 7500 Standish Pl, Rockville, MD 20855, USA.
N1 - Accession Number: 19992213931. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 1649-18-9. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2 - A method is described that confirms the use of the tranquilizer azaperone by detecting the parent compound and the metabolically reduced form, azaperol. Both were detected in swine liver at a target concentration of 10 ppb by gas chromatography/mass spectrometry (GC/MS) with electron ionization in the selected-ion-monitoring mode. Swine liver tissue was ground with dry ice. Acetonitrile was added to extract the drug from the tissue. Sodium chloride buffer was added to the extract in preparation for solid-phase extraction (SPE). The aqueous extract was loaded onto an SPE cartridge designed to extract acidic and neutral drug residues from biological matrices. The cartridge was washed with methanol and conditioned with sodium phosphate buffer. Azaperone and azaperol residues were eluted with a 2% ammonium hydroxide in ethyl acetate. The extracts were evaporated to dryness under a stream of nitrogen and reconstituted in ethyl acetate for GC/MS analysis. A DB-1 analytical column was used to separate the compounds before electron ionization. The parent ion, the base peak ion, and one diagnostic fragment ion were monitored for both compounds. The method was validated with fortified tissue samples containing both azaperone and azaperol. Azaperone-incurred tissues were also analysed, and the presence of the parent drug and the metabolically reduced form, azaperol, were confirmed.
KW - azaperone
KW - detection
KW - drug residues
KW - extraction
KW - food hygiene
KW - gas chromatography
KW - GC-MS
KW - liver
KW - mass spectrometry
KW - meat hygiene
KW - pigmeat
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gas chromatography-mass spectrometry
KW - hogs
KW - pork
KW - swine
KW - Animal Toxicology, Poisoning and Pharmacology (LL900) (Discontinued March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of microbial receptor assay to quantitation of residues of spectinomycin in bovine milk and comparison with liquid chromatographic analysis.
AU - Badar Shaikh
AU - Schermerhorn, P.
AU - Adam, L. A.
AU - Bredow, J. D. von
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 4
SP - 1002
EP - 1005
SN - 1060-3271
AD - Badar Shaikh: U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 19990404370. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 21736-83-4, 22189-32-8, 1695-77-8. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science; Veterinary Science
N2 - Spectinomycin-contaminated bovine milk samples were assayed by liquid chromatographic (LC) and microbial receptor methods. LC involved a newly developed analytical method to quantify the concentration of spectinomycin in the contaminated milk samples. The receptor assay used reagents and the reaction system used for the Charm II spectinomycin assay. Three standard curves (selected range, full range and second-order polynomial) were plotted for the receptor assay and used to quantify spectinomycin in contaminated milk samples. The levels of spectinomycin obtained by the receptor assay, using only the standard curve in the selected range, were comparable with the results obtained by LC analysis.
KW - analytical methods
KW - antibiotic residues
KW - contamination
KW - cows
KW - drug residues
KW - liquid chromatography
KW - milk
KW - spectinomycin
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticides and Drugs (General) (HH400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Solid-phase extraction method for patulin in apple juice and unfiltered apple juice.
AU - Trucksess, M. W.
AU - Tang YiFeng
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 5
SP - 1109
EP - 1113
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19991203124. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 64-19-7, 60-29-7, 149-29-1. Subject Subsets: Medical & Veterinary Mycology
N2 - A solid-phase extraction method was developed for apple juice and unfiltered apple juice in the USA. A portion of the test sample (5 ml) was passed through a macroporous copolymer cartridge and was washed with 1 ml 1% sodium bicarbonate and then with 1 ml 1% acetic acid. Patulin was eluted with 3 ml 2% acetonitrile in anhydrous ethyl ether and was determined by reversed-phase liquid chromatography with UV detection at 276 nm. Recoveries ranged from 93 to 104% in test samples spiked at 20-100 µg/litre.
KW - acetic acid
KW - analytical methods
KW - apple juice
KW - estimation
KW - ethyl ether
KW - liquid chromatography
KW - metabolites
KW - mycotoxins
KW - patulin
KW - techniques
KW - analytical techniques
KW - diethyl ether
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of lipids in infant formula powder by direct extraction methylation of lipids and fatty acid methyl esters (FAME) analysis by gas chromatography.
AU - Cantellops, D.
AU - Reid, A. P.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 5
SP - 1128
EP - 1139
SN - 1060-3271
AD - Cantellops, D.: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta Center for Nutrient Analysis, 60 8th St, Atlanta, GA 30309, USA.
N1 - Accession Number: 19990405256. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Fatty acid methyl esters (FAMEs) of pure triglyceride standards, oils, and fat from dry matrixes were formed by transesterification using sodium methoxide in methanol-hexane. FAMEs were produced by direct addition of sodium methoxide-hexane to samples and heating to simultaneously extract and transesterify acyl lipids. FAMEs were quantified by capillary gas chromatography (GC) over a fatty acid concentration range of 0-1.7 mg/ml (r≥ 0.9997). Total fat was calculated as the sum of individual fatty acids expressed as triglyceride equivalents, in accordance with [US]nutrition labelling guidelines. Saturated, polyunsaturated and monounsaturated fats were calculated as sums of individual free fatty acids. Absolute recoveries determined from individual fatty acids in test samples ranged from 69.7 to 106%. Recoveries (relative to the C13:0 internal standard) for individual fatty acids in test samples ranged from 95 to 106%. Reproducibility was constant at each fatty acid level in the reaction mixture (n = 5, coefficient of variation <2%). Absolute recovery determined from the sum of total fatty acids in standard reference material (SRM) 1846 (dried infant formula) was 96.4%. Analysis of SRM 1846 gave results that were comparable with the certified fat and fatty acid values. Analysis of commercial infant formula gave results that were comparable to those obtained with AOAC Method 996.01. The direct extraction methylation procedure was rapid, and the transesterification of acyl lipids to form FAMEs was completed within 15 min. Classical saponification and refluxing were not required. The method provided FAMEs free of interferences and easily quantified by GC or confirmed by GC/mass spectrometry (MS). Unambiguous MS identification of individual FAMEs derived from pure standards, SRM 1846 and dried infant formula was obtained.
KW - analytical methods
KW - chromatography
KW - esterification
KW - esters
KW - extraction
KW - fats
KW - fatty acids
KW - gas chromatography
KW - GC-MS
KW - guidelines
KW - infant formulae
KW - lipids
KW - methylation
KW - milk products
KW - oils
KW - quality controls
KW - quality standards
KW - analytical techniques
KW - dairy products
KW - gas chromatography-mass spectrometry
KW - infant formula
KW - infant formulas
KW - lipins
KW - quality assurance
KW - recommendations
KW - Laws and Regulations (DD500)
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of vitamin K1 in milk-based infant formula with matrix solid-phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 5
SP - 1140
EP - 1145
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 8th St., Atlanta, GA 30309, USA.
N1 - Accession Number: 19990405257. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 12001-79-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - A liquid chromatographic method for the analysis of vitamin K1 in milk-based infant formula is described. The vitamin was extracted from infant formula by matrix solid-phase dispersion and quantified by reversed-phase chromatography with fluorescence detection. Vitamin K1 was converted to the fluorescent hydroquinone with a post-column zinc reductive reactor. The limit of detection was 12 pg, and the limit of quantification was 38 pg on-column. Linear responses were obtained in the range 0.55-22.1 ng/ml (r² = 0.9998). Recoveries of vitamin K1 from an analyte-fortified blank material for milk-based infant formula averaged 91.7% (n = 25). It is concluded that the method provides a rapid, specific and easily controlled assay for vitamin K1 in fortified infant formula.
KW - analytical methods
KW - chromatography
KW - infant formulae
KW - liquid chromatography
KW - milk
KW - milk products
KW - vitamin K
KW - vitamins
KW - analytical techniques
KW - dairy products
KW - infant formula
KW - infant formulas
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990405257&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue determination of abamectin, doramectin, ivermectin, and moxidectin in milk using liquid chromatography and fluorescence detection.
AU - Schenck, F. J.
AU - Lagman, L. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 1999///
VL - 82
IS - 6
SP - 1340
EP - 1344
SN - 1060-3271
AD - Schenck, F. J.: U.S. Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 20000402533. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 117704-25-3, 70288-86-7. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science; Veterinary Science
N2 - Abamectin, doramectin, ivermectin and moxidectin residues were isolated from milk by a series of liquid-liquid extraction steps, derivatized with trifluoroacetic anhydride, and determined by liquid chromatography with fluorescence detection. Recoveries of >80% (1-30 ng/ml) were achieved for all 4 compounds.
KW - analytical methods
KW - antibiotic acaricides
KW - antibiotic nematicides
KW - avermectins
KW - doramectin
KW - fluorescence
KW - ivermectin
KW - lactones
KW - liquid chromatography
KW - milk
KW - residues
KW - analytical techniques
KW - Pesticides and Drugs (General) (HH400)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000402533&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on infections with the Berok strain of Plasmodium cynomolgi in monkeys and mosquitoes.
AU - Collins, W. E.
AU - Warren, M.
AU - Galland, G. G.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1999///
VL - 85
IS - 2
SP - 268
EP - 272
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Chamblee, GA 30341, USA.
N1 - Accession Number: 19990805043. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Over the years since its discovery in 1963, infections with the Berok strain of Plasmodium cynomolgi were induced in the following monkey species: Macaca mulatta, M. fascicularis, M. nemestrina, Aotus lemurinus griseimembra, A. azarae boliviensis, and Saimiri boliviensis, using either trophozoite-infected erythrocytes, or sporozoites from Anopheles peditaeniatus, A. maculatus, A. quadrimaculatus, A. culicifacies, and A. dirus. This strain of P. cynomolgi offers significant potential for experimental studies. It induced high-density parasite counts in both Old World and New World monkeys (although not in M. fascicularis or M. nemestrina); rhesus monkeys (M. mulatta) readily supported the development of gametocytes infectious to different anopheline mosquitoes routinely maintained in the laboratory; the gametocytes were infective to laboratory-maintained A. albimanus, a vector rarely susceptible to Plasmodium from Old World monkeys; encapsulated oocysts were produced in A. culicifacies as well as in A. gambiae; and the parasite has been adapted to long-term in vitro culture.
KW - animal diseases
KW - disease vectors
KW - experimental infection
KW - experimental infections
KW - gametocytes
KW - human diseases
KW - in vitro
KW - in vitro culture
KW - laboratory animals
KW - mosquito-borne diseases
KW - oocysts
KW - parasites
KW - sporozoites
KW - trophozoites
KW - vector-borne diseases
KW - Anopheles albimanus
KW - Anopheles culicifacies
KW - Anopheles dirus
KW - Anopheles gambiae
KW - Anopheles maculatus
KW - Anopheles peditaeniatus
KW - Anopheles quadrimaculatus
KW - Aotus
KW - Aotus azarae
KW - Aotus lemurinus
KW - Culicidae
KW - Diptera
KW - Macaca fascicularis
KW - Macaca mulatta
KW - Macaca nemestrina
KW - monkeys
KW - Plasmodium cynomolgi
KW - protozoa
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Macaca
KW - Cercopithecidae
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - Aotus azarae boliviensis
KW - Aotus azarai
KW - Aotus lemurinus griseimembra
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Laboratory Animal Science (LL040)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805043&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation of the AMRU-1 strain of Plasmodium vivax to Aotus and Saimiri monkeys and to four species of anopheline mosquitoes.
AU - Sullivan, J. S.
AU - Morris, C. L.
AU - Richardson, B. B.
AU - Galland, G. G.
AU - Jennings, V. M.
AU - Kendall, J.
AU - Collins, W. E.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 1999///
VL - 85
IS - 4
SP - 672
EP - 677
SN - 0022-3395
AD - Sullivan, J. S.: Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 20000803761. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - A chloroquine-resistant strain of Plasmodium vivax (AMRU-1) from Papua New Guinea has been adapted to grow in 4 species of Aotus (A. lemurinus griseimembra, A. vociferans, A. nancymai and A. azarae boliviensis), hybrid Aotus and Saimiri boliviensis monkeys. Whereas it was possible to infect Saimiri monkeys with this parasite by inoculation of parasitized erythrocytes, only 42% of Saimiri monkeys became infected, compared to 92% of Aotus monkeys. Comparative mosquito feedings showed that only A. vociferans, A. l. griseimembra and Saimiri boliviensis produced infections in mosquitoes. Oocysts were observed on the guts of the 4 species of mosquitoes used (Anopheles gambiae, A. stephensi, A. freeborni and A. dirus), but sporozoite transmission was effected only by intravenous inoculation of sporozoites from A. dirus into an Aotus l. griseimembra monkey.
KW - experimental infection
KW - infectivity
KW - laboratory animals
KW - oocysts
KW - parasites
KW - strains
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Aotus
KW - Aotus azarae
KW - Aotus lemurinus
KW - Aotus nancymai
KW - Aotus vociferans
KW - Culicidae
KW - Diptera
KW - Plasmodium vivax
KW - Primates
KW - protozoa
KW - Saimiri
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - experimental transmission
KW - mosquitoes
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000803761&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Morphological comparisons between two species of Blattella (Dictyoptera: Blattellidae).
AU - Lawless, L. S.
JO - Annals of the Entomological Society of America
JF - Annals of the Entomological Society of America
Y1 - 1999///
VL - 92
IS - 1
SP - 139
EP - 143
SN - 0013-8746
AD - Lawless, L. S.: U.S. Food and Drug Administration, 900 Madison Avenue, Baltimore, MD 21201, USA.
N1 - Accession Number: 19990502247. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Blattella asahinai and B. germanica exhibit behavioural differences but are morphologically similar. It has become a necessity in the food and pest control industry to differentiate between these species. The morphological differences in 4 body structures (left mandible, right tegmen, hind-wings, and cerci) that may be used to differentiate the 2 species are presented.
KW - differentiation
KW - identification
KW - morphology
KW - Blattaria
KW - Blattella asahinai
KW - Blattella germanica
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Blattella
KW - Blattellidae
KW - Blattodea
KW - German cockroach
KW - Public Health and Nuisance Pests (VV300) (Discontinued March 2000)
KW - Anatomy, Morphology and Structure (General) (ZZ310) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990502247&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Independent selection of multiple mechanisms for pyrethroid resistance in Guatemalan Anopheles albimanus (Diptera: Culicidae).
AU - Brogdon, W. G.
AU - McAllister, J. C.
AU - Corwin, A. M.
AU - Cordon-Rosales, C.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 1999///
VL - 92
IS - 2
SP - 298
EP - 302
SN - 0022-0493
AD - Brogdon, W. G.: Entomology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 19990504888. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 50-29-3, 121-75-5, 52645-53-1. Subject Subsets: Medical & Veterinary Entomology
N2 - Isofemale lines were established containing either, both, or neither of the elevated esterase and oxidase resistance mechanisms conferring pyrethroid resistance in a Guatemalan strain of A. albimanus. Plots of esterase and oxidase levels for individual mosquitoes from these single families correlated with data obtained using oxidase and esterase synergists in bioassays run in the bottle format. Mixed populations of pyrethroid-resistant A. albimanus adult females were selected using DDT, permethrin, or malathion; and the esterase and oxidase levels of the individual progeny were plotted. These data showed that the 3 classes of insecticide selected the 2 mechanisms differently. These results are discussed in terms of the problem of multiresistance surveillance in the field, especially concerning pyrethroid insecticides and the interaction of agricultural and public health insecticide application.
KW - DDT
KW - esterases
KW - insecticide resistance
KW - malathion
KW - organochlorine insecticides
KW - organophosphorus insecticides
KW - oxidoreductases
KW - permethrin
KW - pyrethroid insecticides
KW - resistance mechanisms
KW - Guatemala
KW - Anopheles albimanus
KW - Culicidae
KW - Diptera
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - dicophane
KW - mosquitoes
KW - redox enzymes
KW - Pesticide and Drug Resistance (HH410)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990504888&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular cloning and nuclear localization of a histone deacetylase homologue in Plasmodium falciparum.
AU - Joshi, M. B.
AU - Lin, D. T.
AU - Chiang PeiHua
AU - Goldman, N. D.
AU - Fujioka, H.
AU - Aikawa, M.
AU - Syin Chiang
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 1999///
VL - 99
IS - 1
SP - 11
EP - 19
SN - 0166-6851
AD - Joshi, M. B.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19990802918. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology
N2 - Histone deacetylase (HDAC) was recently suggested to be the target of a fungus-derived antiprotozoal agent exhibiting structural similarity to known HDAC inhibitors. A study of HDAC in Plasmodium falciparum was initiated to evaluate its potential as the target for novel antimalarials and its role in parasite development. The HDACl gene was isolated from P. falciparum genomic and cDNA libraries. The nucleotide sequence contains no intervening sequence and its open reading frame (ORF) codes for a protein of 449 amino acid residues. The protein was named PfHDACl, as the sequence shows significant homology to yeast, human and other eukaryotic HDACs. Northern blot analysis of the total RNA from different asexual and sexual stages of P. falciparum reveals the presence of single messenger RNA transcript, which is predominantly expressed in mature asexual blood stages and in gametocytes. Antiserum raised against a carboxyl terminal peptide immunoprecipitated an in vitro translated P. falciparum HDAC gene product and recognized an ~ 50 kDa protein in the Triton X-100 insoluble fraction of parasites. Immunoelectron microscopy analysis showed most of the protein localized in the nucleus. This is thought to be the first HDAC gene isolated from Plasmodium. Nucleotide sequence data have been submitted to GenBank under accession number AF091326.
KW - amino acids
KW - biochemistry
KW - developmental stages
KW - DNA libraries
KW - drug targets
KW - enzyme inhibitors
KW - enzymes
KW - gene expression
KW - genes
KW - messenger RNA
KW - nuclei
KW - nucleotide sequences
KW - open reading frames
KW - parasites
KW - proteins
KW - RNA
KW - Plasmodium falciparum
KW - protozoa
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - cell nuclei
KW - DNA sequences
KW - growth phase
KW - histone deacetylase
KW - mRNA
KW - ORFs
KW - ribonucleic acid
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Animal Genetics (LL220) (Discontinued March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990802918&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of energy and nutrient sources of elderly Hispanics and non-Hispanic whites in New Mexico.
AU - Pareo-Tubbeh, S. L.
AU - Romero, L. J.
AU - Baumgartner, R. N.
AU - Garry, P. J.
AU - Lindeman, R. D.
AU - Koehler, K. M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1999///
VL - 99
IS - 5
SP - 572
EP - 582
SN - 0002-8223
AD - Pareo-Tubbeh, S. L.: US Food and Drug Administration, CFSAN HFS-728, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 19991408800. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 50-81-7, 7440-70-2, 59-30-3, 65-23-6, 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - The study identified and compared frequently consumed foods and important food sources of energy, protein, total fat, retinol, ascorbic acid, vitamin E, pyridoxine, folate, and calcium in elderly Hispanics and non-Hispanic whites. Dietary intake data were collected using a modified Health Habits and History Questionnaire (a food frequency questionnaire) for 735 subjects who participated in the New Mexico Elder Health Survey. The sample consisted of 330 Hispanics (176 men and 154 women) and 405 non-Hispanic whites (214 men and 191 women) between the ages of 65 and 96 years. Subjects were those with food frequency data among 883 participants who completed the clinical visit of the New Mexico Elder Health Survey. Results show the top-ranked frequently consumed foods by gender and ethnicity and top-ranked food sources of energy and 8 nutrients. Regional foods were important sources of nutrients in the diets of both Hispanics and non-Hispanic whites, however, more so for the Hispanics. Chile sauces were notable sources of retinol, ascorbic acid, and folic acid among both groups. Both ethnic groups demonstrated selection of low-fat and skim milk and moderation in consumption of red meat. These data will be useful for designing nutrition education programs, for studying the relationship between diet and disease among elderly Hispanics and non-Hispanic whites, and for designing assessment instruments for the elderly and other ethnic populations.
KW - ascorbic acid
KW - calcium
KW - diet
KW - diet studies
KW - elderly
KW - ethnic groups
KW - fat
KW - folic acid
KW - foods
KW - Hispanics
KW - low fat products
KW - meat products
KW - old age
KW - pyridoxine
KW - retinol
KW - sex differences
KW - vitamin E
KW - New Mexico
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - aged
KW - axerophthol
KW - elderly people
KW - folacin
KW - folate
KW - older adults
KW - senior citizens
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - vitamin C
KW - Human Nutrition (General) (VV100)
KW - Social Structure (UU480) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991408800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infant formula preparation, handling, and related practices in the United States.
AU - Fein, S. B.
AU - Falci, C. D.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 1999///
VL - 99
IS - 10
SP - 1234
EP - 1240
SN - 0002-8223
AD - Fein, S. B.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-727, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001406705. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Practices related to infant formula feeding: diluting and concentrating formula, mixing formula with warm tap water, sterilizing, storing prepared formula, heating in a microwave oven, putting the infant to bed with a bottle, and adding cereal and sweeteners to formula were described. Characteristics related to compliance with recommended practices were analysed and the relation between formula handling and infant diarrhoea was examined. Data are from the US Food and Drug Administration's Infant Feeding Practices Study (IFPS), a national longitudinal survey with a non-probability sample. Data were collected by post, and formula practices were included at infant ages 2, 5, and 7 months. Logistic regression was conducted and percentages and odds ratios were calculated, adjusting for instruction in preparing formula from a health care professional, education, income, age, parity, work status, and breast-feeding practices. Failure to comply with recommendations was high for several practices with clear health implications; 33% of mothers mixed formula with warm tap water and up to 48% heated bottles in a microwave oven. Mothers of 2-month-old infants who received instruction from a health care professional and who breast-fed showed increased compliance, but few demographic characteristics, such as education, were related. Diarrhoea increased with ambient holding of formula for older infants. It is concluded that advice from a health care professional can improve formula-handling behaviours. Dietitians and other health care professionals should provide information on proper preparation and handling of infant formula to all infant caregivers.
KW - diarrhoea
KW - guidelines
KW - health
KW - health care
KW - infant feeding
KW - infant formulae
KW - infants
KW - nutrition education
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - diarrhea
KW - infant formula
KW - infant formulas
KW - recommendations
KW - scouring
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Physiology of Human Nutrition (VV120)
KW - Education, Extension, Information and Training (General) (CC000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001406705&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Postantibiotic effect of ampicillin/sulbactam against mycobacteria.
AU - Prabhakaran, K.
AU - Harris, E. B.
AU - Randhawa, B.
JO - Microbios
JF - Microbios
Y1 - 1999///
VL - 99
IS - 393
SP - 113
EP - 122
SN - 0026-2633
AD - Prabhakaran, K.: GWL Hansen's Disease Center at Louisiana State University, US Public Health Service, PO Box 25072, Baton Rouge, LA 70894-2059, USA.
N1 - Accession Number: 20002006057. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 68373-14-8.
N2 - The postantibiotic effect (PAE) of ampicillin/sulbactam (Unasyn) was investigated against 6 species of mycobacteria (Mycobacterium avium, M. africanum, M. bovis BCG, M. simiae, M. scrofulaceum and M. tuberculosis H37Ra) using spectrophotometry. The cell counter method was also used in one set of experiments. The bacteria were exposed to ampicillin/sulbactam for 2 h, 24 h, 72 h or 7-10 days. Five concentrations, 5, 10, 50 or 100 µg/ml, of the drug were tested. Afterwards, the bacteria were washed free of Unasyn and allowed to multiply. Treatment of the mycobacteria for 2 h did not produce any PAE, although 100 µg/ml of the drug caused slower growth. Exposure to 50, 60 or 100 µg/ml, resulted in a prolonged PAE of approx. 3 days. The data on the PAE of UnasynR may be of clinical relevance in determining dosage regimens of the drug.
KW - ampicillin
KW - antibiotics
KW - BCG vaccine
KW - in vitro
KW - slowly growing strains
KW - spectrophotometry
KW - sulbactam
KW - Mycobacterium
KW - Mycobacterium avium
KW - Mycobacterium bovis
KW - Mycobacterium tuberculosis
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterium
KW - Pesticides and Drugs (General) (HH400)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002006057&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of novel methodologies on the analysis of conjugated linoleic acid (CLA). Implications of CLA feeding studies.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Yurawecz, M. P.
AU - Sehat, N.
AU - Roach, J. A. G.
AU - Eulitz, K.
AU - Fritsche, J.
AU - Dugan, M. E. R.
AU - Ku, Y.
JO - Fett/Lipid
JF - Fett/Lipid
Y1 - 1999///
VL - 101
IS - 7
SP - 235
EP - 243
AD - Mossoba, M. M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St., S.W. Washington, DC 20204, USA.
N1 - Accession Number: 19991412709. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 56 ref. Registry Number: 60-33-3, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition
KW - analytical methods
KW - conjugated linoleic acid
KW - feeding
KW - foods
KW - health
KW - human milk
KW - isomers
KW - linoleic acid
KW - meat
KW - meat products
KW - milk
KW - milk products
KW - nutrition
KW - reviews
KW - man
KW - ruminants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Artiodactyla
KW - analytical techniques
KW - breast milk
KW - dairy products
KW - Techniques and Methodology (ZZ900)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991412709&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Conjugated linoleic acid (CLA) isomers: formation, analysis, amounts in foods, and dietary intake.
AU - Fritsche, J.
AU - Rickert, R.
AU - Steinhart, H.
AU - Yurawecz, M. P.
AU - Mossoba, M. M.
AU - Sehat, N.
AU - Roach, J. A. G.
AU - Kramer, J. K. G.
AU - Ku, Y.
JO - Fett/Lipid
JF - Fett/Lipid
Y1 - 1999///
VL - 101
IS - 8
SP - 272
EP - 276
AD - Fritsche, J.: US Food and Drug Administration, Center of Food Safety and Applied Nutrition, Office of Food Labeling, Washington, USA.
N1 - Accession Number: 19991414260. Publication Type: Journal Article. Language: English. Language of Summary: German. Number of References: 42 ref. Registry Number: 60-33-3, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Dairy Science
N2 - Conjugated linoleic acids (CLA) are reviewed under the following headings: formation, analysis of CLA isomers, CLA content in foods and dietary CLA intake. CLA contents of 139 food samples (milk/milk products, meat/meat products, edible oils, margarines, fish and deep-fried products) from the German market are tabulated.
KW - analytical methods
KW - conjugated linoleic acid
KW - fish
KW - food products
KW - foods
KW - intake
KW - isomers
KW - linoleic acid
KW - margarine
KW - meat products
KW - milk
KW - milk products
KW - oils
KW - reviews
KW - analytical techniques
KW - dairy products
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
KW - Meat Produce (QQ030)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fungal spores: hazardous to health?
AU - Sorenson, W. G.
A2 - Rylander, R.
A2 - Etzel, R.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 1999///
VL - 107
IS - Suppl. 3
SP - 469
EP - 472
SN - 0091-6765
AD - Sorenson, W. G.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
N1 - Accession Number: 20001202253. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 58 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The health effects in man due to mycotoxins and fungi in general are reviewed, including infections, allergies and inflammation. The health effects due to the inhalation of mycotoxins, mycotoxins in spores, and the effects of mycotoxins on alveolar macrophages and immune function are discussed.
KW - allergies
KW - human diseases
KW - immune response
KW - immunology
KW - infections
KW - inflammation
KW - macrophages
KW - mycotoxins
KW - reviews
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - fungal toxins
KW - immunity reactions
KW - immunological reactions
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202253&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Pesticide safety training.
AU - Mata, A.
T2 - Public Health Reports
JO - Public Health Reports
JF - Public Health Reports
Y1 - 1999///
VL - 114
IS - 6
SP - 488
EP - 489
SN - 0033-3549
AD - Mata, A.: Migrant Health Program, Bureau of Primary Health Care, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, MD, USA.
N1 - Accession Number: 20000505293. Publication Type: Correspondence. Language: English. Number of References: 2 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - The author comments on Arcury et al.'s article [Public Health Reports (1999) 114, 459-468] about the effectiveness of the Worker Protection Standard in the USA in protecting agricultural workers from occupational pesticide exposure. He emphasises the high rate of occupational exposure to pesticides among migrant and seasonal farm workers.
KW - agricultural entomology
KW - farm workers
KW - legislation
KW - migrant farm workers
KW - nontarget effects
KW - occupational hazards
KW - pesticides
KW - poisoning
KW - safety
KW - USA
KW - arthropods
KW - man
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - toxicosis
KW - United States of America
KW - Worker Protection Standard
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000505293&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in hospitalizations associated with gastroenteritis among adults in the United States, 1979-1995.
AU - Mounts, A. W.
AU - Holman, R. C.
AU - Clarke, M. J.
AU - Bresee, J. S.
AU - Glass, R. I.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 1999///
VL - 123
IS - 1
SP - 1
EP - 8
SN - 0950-2688
AD - Mounts, A. W.: Epidemic Intelligence Service, Epidemiology, Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Dept. of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19992012194. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - Data from the National Hospital Discharge Survey for the years 1979 to 1995 which describes the disease burden and epidemiology of hospitalizations associated with gastroenteritis (GE) among adults in the United States were reviewed. Diarrhoea was listed as a diagnosis on an average of 452 000 hospital discharges per year representing 1.5% of all hospitalizations among adults. The annual number of GE hospitalizations decreased by 20% from approximately 500 000 in 1979 to 400 000 in 1995. The aetiology of 78% of cases coded as GE was undetermined. Until the aetiology of disease can be better established, specific strategies for prevention cannot be developed.
KW - adults
KW - diarrhoea
KW - epidemiology
KW - gastroenteritis
KW - human diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - diarrhea
KW - scouring
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992012194&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Blood safety: the Food and Drug Administration's role.
AU - Gustafson, M.
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
Y1 - 1999///
VL - 123
IS - 6
SP - 475
EP - 477
SN - 0003-9985
AD - Gustafson, M.: Division of Blood Applications, Center for Biologic Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-370, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 19992009720. Publication Type: Journal Article. Language: English. Number of References: 9 ref.
N2 - The US federal government has a role in protecting consumers from threats to the blood supply. These threats range from the residual risks of known infection, to emerging infections that may contaminate the blood supply, to complacency in the area of adherence to product standards and Current Good Manufacturing Practices. The Food and Drug Administration's task is to oversee the safety of the US blood supply. The Food and Drug Administration's regulation of blood and blood components includes preapproval for products entering interstate commerce and adherence to Current Good Manufacturing Practices for all blood components. Overseeing Current Good Manufacturing Practices compliance includes inspection and reporting requirements. These regulatory programmes are coupled with the Public Health Service's ongoing research and epidemiological surveillance. The goals of these programmes are to prevent another infectious disease agent from entering the blood supply as did the human immunodeficiency virus in the early 1980s and to further improve blood safety.
KW - blood
KW - blood transfusion
KW - government organizations
KW - infectious diseases
KW - pathogens
KW - public health
KW - safety
KW - surveillance
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - food and drug administration
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992009720&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of unusual G8 rotavirus strains isolated from Egyptian children.
AU - Holmes, J. L.
AU - Kirkwood, C. D.
AU - Gerna, G.
AU - Clemens, J. D.
AU - Rao, M. R.
AU - Naficy, A. B.
AU - Abu-Elyazeed, R.
AU - Savarino, S. J.
AU - Glass, R. I.
AU - Gentsch, J. R.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 1999///
VL - 144
IS - 7
SP - 1381
EP - 1396
SN - 0304-8608
AD - Holmes, J. L.: Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 19992011276. Publication Type: Journal Article. Language: English. Number of References: 56 ref.
N2 - This is thought to be the first report of the detection of P[14],G8 rotaviruses in Egypt from the stools of children participating in a 3-year study of rotavirus epidemiology. Two strains, EGY1850 and EGY2295, were characterized by a serotyping enzyme immunoassay (EIA), virus neutralization, and sequence analysis of the genes encoding VP7 and the VP8* portion of the VP4 gene. These 2 strains shared a high level of homology of their VP7s (87.8% nucleotide (nt), 97.2% amino acid (aa)) and VP4s (89.6% nt, 97.1% aa) and had the highest VP7 identity to serotype G8 (>82% nt, >92% aa) and VP4 identity to genotype P[14] (≥81% nt, >91% aa) strains. Serological results with a VP7 G8-specific and VP4 P[14]-specific neutralizing monoclonal antibodies supported the genetic classification of EGY1850 and EGY2295 as P[14],G8. Genogroup analysis supported earlier findings that human G8 rotaviruses may be genetically related to bovine rotaviruses.
KW - children
KW - epidemiology
KW - genes
KW - genotypes
KW - human diseases
KW - serotypes
KW - strains
KW - Egypt
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Mediterranean Region
KW - Middle East
KW - North Africa
KW - Africa
KW - human rotavirus
KW - Misr
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19992011276&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - How much time is spent on well-child care and vaccinations?
AU - LeBaron, C. W.
AU - Rodewald, L.
AU - Humiston, S.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 1999///
VL - 153
IS - 11
SP - 1154
EP - 1159
AD - LeBaron, C. W.: National Immunization Program, Centers for Disease Control and Prevention, Public Health Services, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20002005014. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health
N2 - A time-and-motion study was conducted [date not given] at 5 private paediatric practices and 2 public providers in Rochester, New York, USA, to measure the time spent in the various components of well-child care. The study comprised 164 children <2 years of age. The main outcome measure was the duration of family's encounters with the primary care provider (physician or nurse practitioner), nurse, and other personnel. The median encounter times and their component parts in minutes were: primary care provider, 16.3 (physical examination, 4.9; vaccination discussion, 1.9; discussion of other health issues, 9.5; vaccination administration, 0); nurse, 5.6 (physical examination, 3.5; vaccination discussion, 0; other health discussion, 0; vaccine administration, 1.6); and other personnel, 0 for all categories. Public provider setting, African American race of the child, and administration of 4 vaccinations were significantly associated with an increase (3-4 minutes) in the duration of the primary care provider encounter. Only 8 (5%) of the families read vaccine information materials. It is concluded that depending on whether a child makes the usual 3 or recommended 6 well-child visits, the total time of well-child care is 45 to 90 minutes during the first year of life and declines to <30 minutes per year thereafter as the number of recommended visits diminish. It is suggested that because high-risk children make half as many well-child care visits as other children, a 3 to 4 minute increase in encounter time is insufficient to provide them with the same level of care as other children.
KW - children
KW - ethnic groups
KW - health care
KW - human diseases
KW - immunization
KW - nurses
KW - physicians
KW - primary health care
KW - time allocation
KW - timing
KW - vaccination
KW - vaccines
KW - work study
KW - New York
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - doctors
KW - immune sensitization
KW - time and motion study
KW - time study
KW - United States of America
KW - work science
KW - Health Services (UU350)
KW - Host Resistance and Immunity (HH600)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neonatal deaths after hepatitis B vaccine. The vaccine adverse event reporting system, 1991-1998.
AU - Niu, M. T.
AU - Salive, M. E.
AU - Ellenberg, S. S.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 1999///
VL - 153
IS - 12
SP - 1279
EP - 1282
AD - Niu, M. T.: Division of Biostatistics and Epidemiology, Center for Biologic Evaluation and Research, US Food and Drug Administration, Rockville, MD., USA.
N1 - Accession Number: 20002007552. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Reports of neonatal deaths (aged 0-28 days) after hepatitis B (HepB) immunization reported to the US National Vaccine Adverse Event Reporting System (VAERS) were evaluated. All US neonates (0-28 days of age) whose deaths after HepB vaccination given alone were reported to VAERS, occurring from 1 January, 1991, to 5 October, 1998 were included. Of 1771 neonatal reports, there were 18 deaths in 8 boys and 9 girls (1 patient unclassified). The mean age at vaccination for these 18 cases was 12 days (range, 1-27 days); median time from vaccination to onset of symptoms was 2 days (range, 0-20 days); and median time from symptoms to death was 0 days (range, 0-15 days). The mean birth weight of the neonates (n=15) was 3034 g (range, 1828-4678 g). The causes of death for the 17 autopsied cases were sudden infant death syndrome for 12, infection for 3, and 1 case each of intracerebral haemorrhage, accidental suffocation, and congenital heart disease. It is concluded that few neonatal deaths following HepB vaccination have been reported, despite the use of at least 86 million doses of paediatric vaccine given in the USA since 1991. While the limitations of passive surveillance systems do not permit definitive inference, these data suggest that HepB immunization is not causing a clear increase in neonatal deaths.
KW - adverse effects
KW - birth weight
KW - boys
KW - causes of death
KW - children
KW - databases
KW - girls
KW - haemorrhage
KW - heart diseases
KW - hepatitis B
KW - human diseases
KW - immunization
KW - infants
KW - monitoring
KW - mortality
KW - neonates
KW - sudden infant death syndrome
KW - surveillance
KW - vaccination
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bleeding
KW - coronary diseases
KW - cot death
KW - data banks
KW - death rate
KW - hemorrhage
KW - immune sensitization
KW - newborn infants
KW - SIDS
KW - sudden infant death
KW - surveillance systems
KW - United States of America
KW - Information and Documentation (CC300)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis.
AU - Kenney, R. T.
AU - Sacks, D. L.
AU - Sypek, J. P.
AU - Vilela, L.
AU - Gam, A. A.
AU - Evans-Davis, K.
JO - Journal of Immunology (Baltimore)
JF - Journal of Immunology (Baltimore)
Y1 - 1999///
VL - 163
IS - 8
SP - 4481
EP - 4488
SN - 0022-1767
AD - Kenney, R. T.: Laboratory of Parasitic Biology and Biochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.
N1 - Accession Number: 20000804800. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 21645-51-2, 308067-58-5, 9008-11-1. Subject Subsets: Protozoology
N2 - 48 rhesus macaques were used to assess the safety, immunogenicity, and efficacy of a vaccine combining heat-killed Leishmania amazonensis with recombinant human interleukin-12 (rhIL-12) and alum (aluminium hydroxide gel) as adjuvants. The single subcutaneous vaccination was safe and immunogenic, although a small transient nodule developed at the site. Groups receiving rhIL-12 had an augmented in vitro antigen-specific IFN (interferon)-γ response after vaccination, as well as increased production of IgG. No increase in IL-4 or IL-10 was found in cell culture supernatants from either control or experimental groups. Delayed hypersensitivity reactions were not predictive of protection. Intradermal forehead challenge infection with 107 metacyclic L. amazonensis promastigotes 4 weeks after vaccination demonstrated protective immunity in all 12 monkeys receiving 2 µg rhIL-12 with alum and antigen. Partial efficacy was seen with lower doses of rhIL-12 and in groups lacking one or other adjuvant. Antigen alone exacerbated the disease. In conclusion, a single dose vaccine with killed antigen using rhIL-12 and alum as adjuvants was safe and fully effective in this primate model of cutaneous leishmaniasis. This study extends the murine data to primates, and provides a basis for further human trials.
KW - adjuvants
KW - aluminium hydroxide
KW - animal diseases
KW - animal models
KW - antigens
KW - cutaneous leishmaniasis
KW - experimental infections
KW - human diseases
KW - IgG
KW - immunity
KW - immunization
KW - inactivated vaccines
KW - interferon
KW - interleukin 12
KW - laboratory animals
KW - parasites
KW - promastigotes
KW - safety
KW - skin diseases
KW - skin lesions
KW - vaccination
KW - vaccine development
KW - vaccines
KW - Leishmania amazonensis
KW - Macaca mulatta
KW - monkeys
KW - protozoa
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - aluminum hydroxide
KW - antigenicity
KW - dermatoses
KW - immune sensitization
KW - immunogens
KW - killed vaccines
KW - Host Resistance and Immunity (HH600)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Animal Immunology (LL650) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000804800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunity to placental malaria. I. Elevated production of interferon-γ by placental blood mononuclear cells is associated with protection in an area with high transmission of malaria.
AU - Moore, J. M.
AU - Nahlen, B. L.
AU - Misore, A.
AU - Lal, A. A.
AU - Venkatachalam Udhayakumar
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1999///
VL - 179
IS - 5
SP - 1218
EP - 1225
SN - 0022-1899
AD - Moore, J. M.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 19990805260. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2, 308079-78-9. Subject Subsets: Protozoology; Tropical Diseases
N2 - The nature of gravidity-dependent immune protection against placental malaria (PM) was investigated by measuring in vitro production of cytokines by placental intervillous blood mononuclear cells (IVBMC) in women attending an antenatal clinic and delivery ward in Kisumu, western Kenya (an area with perennial malaria transmission with 2 peak transmission periods). The study participants were 78 primi/secundigravidae (50 PM negative and 28 PM positive) and 34 multigravidae (25 PM negative and 9 PM positive). The results demonstrated that interferon (IFN)-γ may be a critical factor in protection against PM: production of this cytokine by PM-negative multigravid IVBMC was elevated compared with PM-negative primigravid and secundigravid and PM-positive multigravid cells. Low IFN-γ responsiveness to malarial antigen stimulation, most evident in the latter group, was balanced by increased interleukin (IL)-4 production, suggesting that counter-regulation of these 2 cytokines may be a crucial determinant in susceptibility to PM. A counter-regulatory relationship between IL-10 and tumour necrosis factor-α was also observed in response to malarial antigen stimulation. It is suggested that elevated production of IFN-γ, as part of a carefully regulated cytokine network, is important in the control of PM.
KW - cytokines
KW - human diseases
KW - immunity
KW - in vitro
KW - interferon
KW - interleukin 10
KW - interleukin 4
KW - malaria
KW - parasites
KW - placenta
KW - pregnancy
KW - tumour necrosis factor
KW - women
KW - Kenya
KW - man
KW - Plasmodium
KW - protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - cachectin
KW - cachexin
KW - gestation
KW - mononuclear cells
KW - multigravidae
KW - placental malaria
KW - primigravidae
KW - secundigravidae
KW - tumor necrosis factor
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990805260&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Two-step purification and partial characterization of a variant of the Vibrio cholerae non-O1 hemolysin.
AU - McCardell, B. A.
AU - Kothary, M. H.
AU - Madden, J. M.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 1999///
VL - 180
IS - 2
SP - 177
EP - 182
SN - 0378-1097
AD - McCardell, B. A.: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, FDA, Washington, DC 20204, USA.
N1 - Accession Number: 20002017221. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 7783-20-2. Subject Subsets: Tropical Diseases
N2 - A two-step purification method using ammonium sulfate precipitation and gel filtration was developed for the purification of a variant of the El Tor haemolysin/cytolysin from supernatant fluids of a Vibrio cholerae non-O1 human isolate (strain 2194c). The toxin displayed delayed elution from a Sephacryl gel filtration column, eluting at between two and three column volumes. The molecular mass and isoelectric point of the purified 2194c toxin were 60 kDa and 5.3, respectively. The N-terminal amino acid sequence was ASPAPANSETNTLPHVAFYI. Purified toxin was cytolytic for Chinese hamster ovary cells and erythrocytes from several animal species.
KW - amino acid sequences
KW - ammonium sulfate
KW - characterization
KW - erythrocytes
KW - haemolysins
KW - methodology
KW - purification
KW - techniques
KW - toxins
KW - Vibrio cholerae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - ammonium sulphate
KW - bacterium
KW - blood red cells
KW - hemolysins
KW - methods
KW - protein sequences
KW - red blood cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002017221&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection.
AU - Jones, L. P.
AU - Erdman, D. D.
AU - Anderson, L. J.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1999///
VL - 180
IS - 2
SP - 500
EP - 504
SN - 0022-1899
AD - Jones, L. P.: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20002007152. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 308067-58-5.
N2 - Persistent infections with human parvovirus B19 (B19) associated with debilitating chronic disease have been described, although evidence linking B19 to these more unusual clinical outcomes has been inconclusive. Recent reports have suggested that the development of antibodies to the B19 nonstructural protein (NS1) following B19 infection might be linked to development of severe arthropathy and chronic infection. To confirm these findings, the C-terminal region of the NS1 protein was expressed for use in Western blot assays for detection of anti-NS1 IgG antibodies in human serum. Among 91 persons tested in the USA, 0 of 20 not previously infected with B19, 9 (36%) of 25 with past B19 infection, and 5 (12.5%) of 40 with recent B19 infection, had detectable anti-NS1 antibodies. Of 6 persons with chronic B19 infection, 2 had detectable antibodies to NS1. The presence of anti-NS1 antibodies did not appear to correlate with unusual clinical outcomes or chronic B19 infection.
KW - antibodies
KW - blood serum
KW - chronic course
KW - chronic infections
KW - clinical aspects
KW - human diseases
KW - IgG
KW - immunopathology
KW - man
KW - Parvovirus
KW - Parvovirus B19
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Parvoviridae
KW - ssDNA viruses
KW - DNA viruses
KW - viruses
KW - Parvovirus
KW - clinical picture
KW - immunopathogenesis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002007152&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - O'nyong-nyong fever in south-central Uganda, 1996-1997: description of the epidemic and results of a household-based seroprevalence survey.
AU - Sanders, E. J.
AU - Rwaguma, E. B.
AU - Kawamata, J.
AU - Kiwanuka, N.
AU - Lutwama, J. J.
AU - Ssengooba, F. P.
AU - Lamunu, M.
AU - Najjemba, R.
AU - Were, W. A.
AU - Bagambisa, G.
AU - Campbell, G. L.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 1999///
VL - 180
IS - 5
SP - 1436
EP - 1443
SN - 0022-1899
AD - Sanders, E. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, San Juan, Puerto Rico.
N1 - Accession Number: 20000504102. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - During January and early February 1997, active case-finding and a household cluster serosurvey were conducted of O'nyong-nyong (ONN) virus in 2 affected and 2 comparison areas in Rakai District, Uganda. A confirmed case was defined as an acute febrile illness with polyarthralgia occurring within the previous 9 months (May 1996-February 1997) plus serologic confirmation or isolation of ONN from blood. In affected (n=129) and comparison (n=115) areas, the estimated infection rates were 45% and 3%, respectively, and the estimated attack rates were 29% and 0%, respectively, for an apparent: inapparent infection ratio of nearly 2 in affected areas. In villages sampled near Lake Kijanebalola, Rakai District, the estimated infection and attack rates were 68% and 41%, respectively, and 55% of sampled households had ≥1 case of ONN fever. It is concluded that this epidemic was focused near lakes and swamps, where it was associated with high infection and attack rates.
KW - arboviruses
KW - epidemics
KW - human diseases
KW - infection
KW - seroprevalence
KW - viral diseases
KW - Uganda
KW - Alphavirus
KW - man
KW - O'nyong-nyong virus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Alphavirus
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - arthropod-borne viruses
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000504102&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of multidrug-resistant Salmonella typhimurium DT104 by multiplex polymerase chain reaction.
AU - Khan, A. A.
AU - Nawaz, M. S.
AU - Khan, S. A.
AU - Cerniglia, C. E.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 1999///
VL - 182
IS - 2
SP - 355
EP - 360
SN - 0378-1097
AD - Khan, A. A.: Division of Microbiology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20002220662. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 73231-34-2, 76639-94-6. Subject Subsets: Veterinary Science; Veterinary Science
N2 - S. typhimurium definitive type 104 (DT104) is a virulent pathogen for humans and animals with many strains having multiple drug resistance characteristics. The organism typically carries resistance to ampicillin, chloramphenicol, florfenicol, streptomycin, sulfonamides and tetracycline (ACSSuT-resistant). A multiplex PCR method was developed to simultaneously amplify four genes, florfenicol (flost), virulence (spvC), invasion (invA), and integron (int) from S. typhimurium DT104 (ACSSuT-type). 22 ACSSuT-resistant DT104 isolates in our collection gave 100% positive reactions to this PCR assay by amplifying 584-, 392-, 321- and 265-bp PCR products, using primers specific to the respective target genes. One Salmonella strain DT23, ACSSuT-resistant, phage type 711 failed to amplify the 584-bp fragment, indicating that this method is specific for DT104-type ACSSuT-resistant S. typhimurium strains. One clinical and one bovine ASSuT-resistant strains that were sensitive to chloramphenicol and florfenicol did not yield a 584-bp fragment, indicating the absence of the flost gene. This method will be useful for rapid identification of ACSSuT-type DT104 strains from clinical, food and environmental samples.
KW - detection
KW - drug resistance
KW - florfenicol
KW - genes
KW - identification
KW - multiple drug resistance
KW - polymerase chain reaction
KW - animals
KW - man
KW - Salmonella typhimurium
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Animal Diseases (LL886) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002220662&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Caloric restriction abolishes enhanced metabolic efficiency induced by ectopic agouti protein in yellow mice.
AU - Wolff, G. L.
AU - Kodell, R. L.
AU - Kaput, J. A.
AU - Visek, W. J.
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
Y1 - 1999///
VL - 221
IS - 2
SP - 99
EP - 104
SN - 0037-9727
AD - Wolff, G. L.: Division of Biochemical Toxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 19991410177. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - Caloric restriction (CR), from approximately 3 months of age, at 70% of the ad libitum (AL) caloric intake prevented development of overt obesity in female "viable yellow" Avy/A (BALB/cStCrlfC3Hf/Nctr × VY/WffC3Hf/Nctr-Avy) F1 hybrid mice. In adult yellow Avy/A mice, CR eliminated the increased metabolic efficiency associated with the presence of agouti protein in ectopic sites. At 4 weeks of age, the yellow Avy/A mice were ~ 14% heavier and by 12 weeks of age, when CR began, they were ~ 24% heavier than the congenic agouti A/a mice. Between 4 and 12 weeks, the yellow mice gained ~ 63% in body weight, whereas the agouti mice gained only ~ 44%. While the comparable AL Avy/A mice gained ~ 128% and the AL A/a mice gained ~ 41% between 12 and 51 weeks of age, the CR Avy/A and A/a mice gained only 16% and 15%, respectively. Mean brain weights of CR mice of both genotypes were lower than those of the comparable ad libitum-fed (AL) groups; however, CR Avy/A mice had slightly, but significantly (P < 0.0001), higher brain weights than CR A/a mice. The larger mean brain weight and retention, during CR, of the somewhat greater prerestriction Avy/A mean body weight compared with prerestriction A/a mice were consistent with the hypothesis that ectopic agouti protein affects somatic growth directly or indirectly. This may be related to altered developmental/metabolic programming in yellow mice, indicated by greater metabolic efficiency and by an early transient increase in circulating IGF-1 levels. The specific cellular processes modulated by the agouti protein in ectopic sites remain to be identified.
KW - body weight
KW - brain
KW - efficiency
KW - food restriction
KW - metabolism
KW - weight
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991410177&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of serology in the diagnosis of Lyme disease.
AU - Brown, S. L.
AU - Hansen, S. L.
AU - Langone, J. J.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 1999///
VL - 282
IS - 1
SP - 62
EP - 66
SN - 0098-7484
AD - Brown, S. L.: Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA.
N1 - Accession Number: 19990505250. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Clarification of the clinical value of serologic testing for Lyme disease using the results of commonly marketed assays for detecting antibody to Borrelia burgdorferi was attempted. Published studies on B. burgdorferi test performance published up to 1998, package insert labelling from FDA-cleared test kits for B. burgdorferi, and Lyme Disease Survey Set LY-A from the College of American Pathologists were reviewed. The sensitivity and specificity of commercial serologic tests (ELISA, immunofluorescence antibody (IFA), and immunodot) were analysed for diagnosis of Lyme disease. It was concluded that these tests, in common use in clinical or commercial laboratories, should be used only to support a clinical diagnosis of Lyme disease, not as the primary basis for making diagnostic or treatment decisions. Serologic testing is not useful early in the course of Lyme disease because of the low sensitivity of tests in early disease. Serologic testing may be more useful in later disease, at which time sensitivity and specificity of the test are improved. Positive or equivocal results on an ELISA, IFA, or immunodot assay require supplementary testing with a Western blot assay. A negative result on the Western blot or ELISA indicates that there is no serologic evidence of infection by B. burgdorferi at the time the sample was drawn.
KW - antibodies
KW - diagnosis
KW - human diseases
KW - immunodiagnosis
KW - Lyme disease
KW - misdiagnosis
KW - performance
KW - serology
KW - Borrelia burgdorferi
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - lyme borreliosis
KW - serological diagnosis
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Human Treatment and Diagnosis (Non-drug) (VV700) (Discontinued March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and validation of an ELISA for metolachlor mercapturate in urine.
AU - Striley, C. A. F.
AU - Biagini, R. E.
AU - Mastin, J. P.
AU - MacKenzie, B. A.
AU - Robertson, S. K.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 1999///
VL - 399
IS - 1/2
SP - 109
EP - 114
SN - 0003-2670
AD - Striley, C. A. F.: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Sciences, 4676 Columbia Parkway, Mailstop C-26, Cincinnati OH 45226, USA.
N1 - Accession Number: 20002302378. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 8 ref. Registry Number: 34256-82-1, 15972-60-8, 51218-45-2. Subject Subsets: Weeds
N2 - The National Institute for Occupational Safety and Health (NIOSH) has conducted an exposure assessment study of herbicide applicators exposed to numerous commercial acetanilide-containing products. An ELISA was developed to measure the putative major human metabolite of one of these, metolachlor mercapturate (MM). Antibodies were obtained by immunizing rabbits with a keyhole limpet haemocyanin (KLH) MM conjugate and the sera used as a source of IgG antibodies for ELISA development. The percent cross-reactivities for metolachlor, acetochlor mercapturate (ACM), alachlor mercapturate (AM) and alachlor were 39 and 23%, respectively. Cross-reactivity for AM and alachlor are not given, as 50% inhibition was not observed for the highest concentration tested. Percent inhibitions at 20 µg litre-1 for MM, metolachlor, ACM, AM and alachlor were 20, 29, 48, 72 and 90%, respectively. The measured least detectable dose of MM was 0.18 µg litre-1. Inter-assay concordance was <15%. These data indicate that the MM ELISA developed in this study may be used to estimate body burdens of ME from urinary metabolites of herbicide applicators.
KW - acetochlor
KW - alachlor
KW - analytical methods
KW - detection
KW - ELISA
KW - herbicides
KW - metabolites
KW - methodology
KW - metolachlor
KW - monitoring
KW - nontarget organisms
KW - safety at work
KW - urine
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - enzyme linked immunosorbent assay
KW - methods
KW - non-target organisms
KW - non-target species
KW - nontarget species
KW - occupational safety
KW - surveillance systems
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aflatoxin B1-induced Hprt mutations in splenic lymphocytes of Fischer 344 rats. Results of an intermittent feeding trial.
AU - Morris, S. M.
AU - Aidoo, A.
AU - Chen, J. J.
AU - Chou, M. W.
AU - Casciano, D. A.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 1999///
VL - 423
IS - 1-2
SP - 33
EP - 38
SN - 0027-5107
AD - Morris, S. M.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Department of Health and Human Services, Jefferson, AR 72079, USA.
N1 - Accession Number: 19991202090. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - The effects of feeding regimen on the induction by aflatoxin B1 (AFB1) of hypoxanthine phosphoribosyl transferase (hprt) mutations were determined in the rat splenic lymphocyte. Fischer 344 rats were fed either (A) a control diet, (B) various doses of AFB1 for 3- to 4-week periods interspersed with two 4-week periods of the control diet or (C) continuously fed 1.6 p.p.m. of AFB1. Not only was a significant increase in the mutant frequency detected in the lymphocytes of rats fed a dose as low as 0.01 p.p.m. of AFB1, but the increase in the mutant frequency at the end of the 20-week experimental period was consistent with an accumulation of damage induced by AFB1. It is concluded that the rat lymphocyte/hprt assay is useful for detecting chronic low level exposures. Further, these data indicate that an intermittent, low-level exposure to AFB1 may present a human health risk.
KW - aflatoxicosis
KW - aflatoxins
KW - diet
KW - lymphocytes
KW - mutagenesis
KW - mutations
KW - mycotoxins
KW - poisoning
KW - spleen
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin poisoning
KW - fungal toxins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction.
AU - Aidoo, A.
AU - Desai, V. G.
AU - Lyn-Cook, L. E.
AU - Chen, J. J.
AU - Feuers, R. J.
AU - Casciano, D. A.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 1999///
VL - 430
IS - 1
SP - 155
EP - 163
SN - 0027-5107
AD - Aidoo, A.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20001420857. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - Calorie restriction modulates spontaneous and chemically induced tumours and increases maximal life span in experimental animals; however, the mechanism by which calorie restriction exerts its ameliorating effects is not fully elucidated, although reduced levels of reactive oxygen species (ROS) by calorie restriction has generated much interest. In the present study, we have determined whether or not calorie restriction would affect the mutagenic response in rats treated with bleomycin (BLM) a radiomimetic drug that is associated with DNA damage by a free radical mechanism. Fourteen weeks after weaning, the rats were divided into two groups; ad libitum (AL)-fed and 40% calorie restriction. Both AL and calorie-restricted animals were injected with 2.5, 5.0 and 10.0 mg BLM/kg, or with phosphate-buffered saline (PBS), and they were killed 4 weeks post drug treatment. Lymphocytes from the spleens were seeded in 96-well microtitre plates to determine mutant frequency in the hypoxanthine guanine phosphoribosyl transferase (Hprt) gene. The mutant frequency in the BLM-treated rats was higher in AL males (P=0.001), and AL females (P=0.0174) than in their calorie-restricted counterparts. The difference in mutagenic response relative to AL males and AL females appeared unrelated to a low percent cloning efficiency seen in the males, since the mean absolute number of Hprt mutant clones was higher in the AL males compared to the females. A reduction in animal weight by calorie restriction was significant in both sexes (P<0.001), but the dose effect appeared non-significant. The results indicate that calorie intake of 60% reduced the mutagenic response of BLM, a compound known to induce oxidative DNA damage, and suggest a possible decrease in ROS as a function of calorie restriction.
KW - calories
KW - diet treatment
KW - drug therapy
KW - energy
KW - free radicals
KW - intake
KW - lymphocytes
KW - neoplasms
KW - weaning
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - chemotherapy
KW - cloning
KW - diet prescription
KW - restriction
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001420857&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved validated assay for the determination of mefloquine and its carboxy metabolite in plasma, serum and whole blood using solid-phase extraction and high-performance liquid chromatography.
AU - Green, M. D.
AU - Bergqvist, Y.
AU - Mount, D. L.
AU - Corbett, S.
AU - D'Souza, M. J.
JO - Journal of Chromatography, B. Biomedical Applications
JF - Journal of Chromatography, B. Biomedical Applications
Y1 - 1999///
VL - 727
IS - 1/2
SP - 159
EP - 165
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0378-4347
AD - Green, M. D.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, 1600 Clifton Road, Mailstop F-12, Atlanta, GA 30333, USA.
N1 - Accession Number: 20003028781. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 51773-92-3, 53230-10-7. Subject Subsets: Protozoology
N2 - An improved HPLC method using a low silanol activity octadecylsilica column and a solid-phase extraction technique was validated for the simultaneous analysis of mefloquine and its carboxy metabolite in whole blood, plasma and serum. An octadecylsilica column with high silanol activity was compared to a column of low activity in terms of pH-dependent variability of chromatographic retention times for mefloquine and its carboxy metabolite. The low silanol activity column showed a relatively large mobile phase pH range where retention times for both components were consistent. The solid-phase extraction procedure consisted of a simple protein precipitation step followed by sample concentration and extraction using a C18 membrane disk. The inter- and intra-assay variability for a therapeutic concentration of mefloquine (1000 ng/ml) was less than 2% in whole blood, plasma and serum, while carboxymefloquine (1000 ng/ml) was 2.3% or less. At concentrations as low as 100 ng/ml, the inter-assay variability was 6.2% or less for both analytes. This method showed a robust analytical procedure for the simultaneous analysis of mefloquine and its carboxy metabolite where precise measurements are useful in pharmacokinetic studies and in estimating drug compliance.
KW - antimalarials
KW - antiprotozoal agents
KW - assays
KW - blood
KW - blood plasma
KW - chromatography
KW - HPLC
KW - mefloquine
KW - metabolites
KW - pH
KW - pharmacokinetics
KW - serum
KW - techniques
KW - carboxymefloquine
KW - high performance liquid chromatography
KW - hydrogen ion concentration
KW - plasma (blood)
KW - potential of hydrogen
KW - Techniques and Methodology (ZZ900)
KW - Pharmacology (VV730) (New March 2000)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003028781&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Automated one-step supercritical fluid extraction and clean-up system for the analysis of pesticide residues in fatty matrices.
AU - Hopper, M. L.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 1999///
VL - 840
IS - 1
SP - 93
EP - 105
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Hopper, M. L.: US Food and Drug Administration, Total Diet and Pesticide Research Center, P.O. Box 15905, Lenexa, KS 66285-5905, USA.
N1 - Accession Number: 20023013027. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Dairy Science; Maize; Agricultural Entomology
N2 - An automated supercritical fluid extraction and in-line cleanup system has been developed for organochlorine and organophosphate pesticide residues contained in fats. This procedure utilizes supercritical carbon dioxide modified with 3% acetonitrile at 27.58 MPa and 60°C to extract and separate the pesticide residues from the fat on a C1 bonded phase preparative column at 95°C. The automated C1 system recovers 86 of 117 nonpolar to moderately polar organochlorine and organophosphate pesticides from fats. Ten of the 31 pesticides not recovered through the system are not recovered through the conventional cleanup sorbent, Florisil. Pesticide residues can be separated from 0.68 g of butterfat and 0.67 g maize oil, resulting in 2.9 mg of butterfat and 2.1 mg maize oil residue co-eluting into the pesticide fraction. Also, this integrated method can extract and cleanup a 5 g sample of fatty foods containing <18% fat and 70% moisture. The automated C1 system is reproducible and the amount of co-extracted sample residue in the pesticide fraction yields results comparable to the current methodology, which uses organic solvent extraction and gel permeation chromatography, along with a final Florisil column cleanup step. The automated C1 system simplifies the extraction and cleanup step while reducing solvent usage and hazardous waste.
KW - fats
KW - maize oil
KW - methodology
KW - milk fat
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - butterfat
KW - corn oil
KW - methods
KW - organic chlorine pesticides
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023013027&site=ehost-live&scope=site
UR - email: Marvin_Hopper@kan.tdrc\Marvin_Hopper@fdaoraswr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reducing liver cancer - global control of aflatoxin.
AU - Henry, S. H.
AU - Bosch, F. X.
AU - Troxell, T. C.
AU - Bolger, P. M.
JO - Science (Washington)
JF - Science (Washington)
Y1 - 1999///
IS - 5449
SP - 2453
EP - 2454
SN - 0036-8075
AD - Henry, S. H.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20001201619. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The effects of aflatoxicosis, public health risks of aflatoxins, and the role of aflatoxins in liver cancer are discussed.
KW - aflatoxicosis
KW - aflatoxins
KW - carcinogenesis
KW - control
KW - human diseases
KW - liver
KW - liver cancer
KW - mycotoxins
KW - neoplasms
KW - poisoning
KW - reviews
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aflatoxin poisoning
KW - cancers
KW - fungal toxins
KW - toxicosis
KW - Human Toxicology, Poisoning and Pharmacology (VV800) (Discontinued March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001201619&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Incidence and behavior of Listeria monocytogenes in fish and seafood.
AU - Jinneman, K. C.
AU - Wekell, M. M.
AU - Eklund, M. W.
A2 - Ryser, E.T.
A2 - Marth, E.H.
T2 - Listeria, listeriosis and food safety.
Y1 - 1999///
IS - Ed. 2
CY - New York; USA
PB - Marcel Dekker Inc.
SN - 0824702352
AD - Jinneman, K. C.: Seafood Products Research Center, U.S. Food and Drug Administration, Bothell, Washington, USA.
N1 - Accession Number: 19991413995. Publication Type: Book chapter. Language: English. Number of References: 107 ref. Subject Subsets: Human Nutrition
N2 - This chapter reviews: FDA surveys of Listeria monocytogenes in domestic and imported seafood; other surveys for L. monocytogenes in fish an#d seafood products-crustaceans, shellfish, fin fish, smoked fish products, lightly processed fish products; Human listeriosis associated with fish and seafood products; regulatory aspects of L. monocytogenes in fish and seafoods; and behaviour of Listeria in fish and seafood<dash>modes of transmission, growth and survival, inhibition, inactivation.
KW - fish
KW - fish products
KW - food safety
KW - products
KW - seafoods
KW - Listeria monocytogenes
KW - man
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991413995&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Recommendations for the use of Lyme disease vaccine. Recommendations of the advisory committee on immunization practices (ACIP).
AU - Dennis, D. T.
AU - Hayes, E. B.
AU - Orloski, K. A.
AU - Meltzer, M. I.
T2 - Morbidity and Mortality Weekly Report
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 1999///
IS - RR-7
SP - 25
EP - 25
SN - 0149-2195
AD - Dennis, D. T.: US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30333, USA.
N1 - Accession Number: 19990505938. Publication Type: Miscellaneous. Language: English. Number of References: 80 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Recommendations for the use of a newly developed recombinant outer-surface protein A (rOspA) Lyme disease (Borrelia burgdorferi infection) vaccine (LYMErix) for persons aged 15-70 years in the USA are provided. The purpose of these recommendations was to provide health-care providers, public health authorities, and the public with guidance regarding the risk of acquiring Lyme disease and the role of vaccination as an adjunct to preventing Lyme disease. Topics addressed include: clinical features of Lyme disease; epidemiology of Lyme disease; prevention of Lyme disease; Lyme disease vaccine; vaccine performance; cost-effectiveness of Lyme disease vaccination; assessing the risk for Lyme disease and recommendations for use of Lyme disease vaccine and future considerations.
KW - clinical aspects
KW - disease control
KW - disease prevention
KW - epidemiology
KW - guidelines
KW - human diseases
KW - immunization
KW - Lyme disease
KW - vaccines
KW - USA
KW - Borrelia burgdorferi
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - clinical picture
KW - immune sensitization
KW - lyme borreliosis
KW - recommendations
KW - United States of America
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19990505938&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health aspects of antibiotic resistance monitoring in the USA.
AU - Tollefson, L.
AU - Fedorka-Cray, P. J.
AU - Angulo, F. J.
A2 - Fossum, K.
A2 - Ihler, C. F.
A2 - Nyberg, O.
A2 - Andresen, Ø.
A2 - Christensen, B.
JO - Acta Veterinaria Scandinavica, Supplementum
JF - Acta Veterinaria Scandinavica, Supplementum
Y1 - 1999///
IS - Supp. 92
SP - 67
EP - 75
AD - Tollefson, L.: DVM, MPH, Center for Veterinary Medicine, U.S Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20002207882. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 15 ref. Subject Subsets: Veterinary Science
KW - antibiotics
KW - drug resistance
KW - monitoring
KW - public health
KW - zoonoses
KW - USA
KW - animals
KW - bacteria
KW - man
KW - eukaryotes
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - surveillance systems
KW - United States of America
KW - zoonotic infections
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Animals (LL820) (Discontinued March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Parasites, Vectors, Pathogens and Biogenic Diseases of Humans (VV200) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002207882&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The oxidation of conjugated linoleic acid.
AU - Eulitz, K.
AU - Yurawecz, M. P.
AU - Ku, Y.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
JO - Advances in conjugated linoleic acid research, volume 1.
JF - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
SP - 55
EP - 63
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Eulitz, K.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19991415454. Publication Type: Miscellaneous. Language: English. Number of References: 35 ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - The antioxidative effects of conjugated linoleic (CLA) acid are well documented. This chapter examines the following aspects of CLA oxidation: oxidation of CLA by singlet oxygen; autoxidation of CLA; and oxidation of 9,12-epoxy-9,11-octadecadienoic acid (F9,12). Figures are presented depicting: Principal oxidation scheme of 1,3-dienes with singlet oxygen; Oxidation mechanism proposed by Manring and Foote for the singlet oxygen oxidation of conjugated dienes; Principal oxidation scheme of furan fatty acids; and Overview of the oxidation of CLA.
KW - conjugated linoleic acid
KW - fatty acids
KW - oxidation
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
KW - Animal Nutrition (General) (LL500)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415454&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Methylation procedures for conjugated linoleic acid.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
AU - Ku, Y.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
JO - Advances in conjugated linoleic acid research, volume 1.
JF - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
SP - 64
EP - 82
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Yurawecz, M. P.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC20204, USA.
N1 - Accession Number: 19991415455. Publication Type: Miscellaneous. Language: English. Number of References: 65 ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - This chapter describes the methylation procedures used for conjugated linoleic acid (CLA). Section headings include: Types of materials containing CLA; Direct analysis of total CLA-supercritical fluid chromatography, high performance liquid chromatography; Preparation of lipid extracts; Methylation procedures-hydrolysis followed by trimethylsilyl(TMS)-diazomethane methylation; Methylation with borontrifluoride/methanol, a useful reference mixture; Theory of acid-catalyzed methylation; and Methylation methods used in the analysis of CLA isomers in the past 10 years.
KW - conjugated linoleic acid
KW - fatty acids
KW - methylation
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
KW - Animal Nutrition (General) (LL500)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415455&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Identification of CLA isomers in food and biological extracts by mass spectrometry.
AU - Roach, J. A. G.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
JO - Advances in conjugated linoleic acid research, volume 1.
JF - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
SP - 126
EP - 140
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Roach, J. A. G.: US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19991415458. Publication Type: Miscellaneous. Language: English. Number of References: 12 ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - This chapter examines the identification of conjugated linoleic acid (CLA) isomers in food and biological extracts by mass spectrometry (MS). Section headings include: Gas chromatography (GC) conditions for CLA; Defining the GC/MS detection limit; Appearance of CLA mass spectra; Quadrupole MD detection of CLA; Magnetic sector MD detection of CLA; and Ion trap MS detection of CLA.
KW - analytical methods
KW - conjugated linoleic acid
KW - extracts
KW - fatty acids
KW - foods
KW - isomers
KW - mass spectrometry
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
KW - Animal Nutrition (General) (LL500)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415458&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Incorporation of conjugated fatty acid into biological matrices.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
AU - Dugan, M. E. R.
AU - Sehat, N.
AU - Mossoba, M. M.
AU - Yin, J. J.
AU - Ku, Y.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
JO - Advances in conjugated linoleic acid research, volume 1.
JF - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
SP - 238
EP - 252
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Yurawecz, M. P.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 19991415722. Publication Type: Miscellaneous. Language: English. Number of References: 62 ref. Subject Subsets: Human Nutrition
N2 - This chapter reviews the results of conjugated fatty acid (CFA) incorporation into biological matrices from natural sources or CFA mixtures.
KW - fatty acids
KW - lipids
KW - membranes
KW - conjugated fatty acids
KW - lipins
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415722&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Formation, contents and estimation of daily intake of conjugated linoleic acid isomers and trans-fatty acids in foods.
AU - Fritsche, J.
AU - Rickert, R.
AU - Steinhart, H.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Fritsche, J.: US Food and Drug Administration, Center of Food Safety and Applied Nutrition, Office of Food Labeling, Washington, DC 20204, USA.
N1 - Accession Number: 19991415734. Publication Type: Book chapter. Language: English. Number of References: 74 ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Dairy Science
N2 - This chapter examines conjugated linoleic acid (CLA) and trans fatty acids (TFA) in food. Issues discussed include: formation of CLA and TFA; edible oils and margarine; milk and milk products; meat, meat products and fish; cakes, pastries and other processed foods; isomeric distribution of CLA isomers; and estimation and evaluation of daily TFA and CLA intake.
KW - bakery products
KW - conjugated linoleic acid
KW - fatty acids
KW - fish
KW - foods
KW - intake
KW - isomers
KW - margarine
KW - meat
KW - meat products
KW - milk
KW - milk products
KW - plant oils
KW - trans fatty acids
KW - baked goods
KW - dairy products
KW - vegetable oils
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Confirmation of conjugated linoleic acid geometric isomers by capillary gas chromatography-Fourier transform infrared spectroscopy.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
AU - Eulitz, K. D.
AU - Fritsche, J.
AU - Sehat, N.
AU - Roach, J. A. G.
AU - Ku, Y.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G.
T2 - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Mossoba, M. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 19991415459. Publication Type: Book chapter. Language: English. Number of References: 29 ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - This chapter examines the following methods for the identification of conjugated linoleic acid (CLA) isomers: dispersive infrared and Fourier transform infrared spectroscopy (FTIR); capillary gas chromatography-FTIR interfaces; CLA geometric isomers in chemical and biological matrices; conjugated octadecatrienes in edible fats and oils; CLA artifacts and methoxy fatty acid artifacts; and CLA oxidation products.
KW - analytical methods
KW - conjugated linoleic acid
KW - fatty acids
KW - gas chromatography
KW - isomers
KW - oxidation
KW - spectroscopy
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Human Nutrition (General) (VV100)
KW - Animal Nutrition (General) (LL500)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991415459&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Advances in conjugated linoleic acid research, volume 1.
A2 - Yurawecz, M. P.
A2 - Mossoba, M. M.
A2 - Kramer, J. K. G.
A2 - Pariza, M. W.
A2 - Nelson, G. J.
T2 - Advances in conjugated linoleic acid research, volume 1.
Y1 - 1999///
CY - Champaign; USA
PB - AOCS Press
SN - 1893997022
AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC, USA.
N1 - Accession Number: 19991415449. Publication Type: Book. Language: English. Number of References: many ref. Registry Number: 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science; Pig Science
N2 - This book reviews research into conjugated linoleic acid. Chapters include: Conjugated linoleic acid (CLA)-the early years; The biological activities of CLA; Preparation of unlabelled and isotope-labelled CLA and related fatty acid isomers; Commercial production of CLA; The oxidation of CLA; Methylation procedures for CLA; Separation of conjugated fatty acid isomers; Gas chromatography (electron impact) mass spectrometry analysis of CLA using different derivatization techniques; Identification of CLA isomers in food and biological extracts by mass spectrometry; Confirmation of CLA geometric isomers by capillary gas chromatography-Fourier transform infrared spectroscopy; Nuclear magnetic resonance (NMR) spectroscopic analysis of CLA esters; Identification and quantification of CLA isomers in fatty acid mixtures by 13C NMR spectroscopy; Biosynthesis of CLA and its incorporation into meat and milk in ruminants; Endogenous synthesis of rumenic acid in rodents and humans; Effect of ionophores on CLA in ruminal cultures and in the milk of dairy cows; Species-dependent, seasonal and dietary variation of CLA in milk; Dietary control of immune-induced cachexia-CLA and immunity; Incorporation of conjugated fatty acid into biological matrices; Bone metabolism and dietary CLA; CLA and the risk of breast cancer; CLA in lipids of fish tissues; CLA's in human milk; Influence of dietary CLA on lipid metabolism in relation to its anticarcinogenic activity; CLA metabolites in rats; Effect of CLA on polyunsaturated fatty acid metabolism and immune function; Regulation of stearoyl-CoA desaturase by CLA; CLA for altering body composition and treating obesity; Feeding CLA to pigs-effects on feed conversion carcass composition, meat quality and palatability; Dietary sources and intakes of CLA intake in humans; Formation, contents and estimation of daily intake of CLA isomers and trans-fatty acids in foods; CLA and experimental atherosclerosis in rabbits; Modulation of diabetes by CLA; CLA as a nutraceutical-observations in the context of 15 years of n-3 polyunsaturated fatty acid research; Cancer inhibition in animals; and Intake of dairy products and breast cancer risk.
KW - body composition
KW - breast cancer
KW - cachexia
KW - carcass composition
KW - carcinogenesis
KW - conjugated linoleic acid
KW - diabetes
KW - fatty acids
KW - feed conversion
KW - human milk
KW - immunity
KW - intake
KW - ionophores
KW - isomers
KW - lipid metabolism
KW - mammary gland neoplasms
KW - meat
KW - meat quality
KW - metabolites
KW - milk
KW - milk products
KW - neoplasms
KW - obesity
KW - oxidation
KW - palatability
KW - polyenoic fatty acids
KW - sources
KW - synthesis
KW - trans fatty acids
KW - man
KW - pigs
KW - rats
KW - rodents
KW - ruminants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Muridae
KW - rodents
KW - breast milk
KW - cancers
KW - dairy products
KW - fat metabolism
KW - fatness
KW - hogs
KW - mammary tumour
KW - polyunsaturated fatty acids
KW - rumenic acid
KW - swine
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Nutrition (Production Responses) (LL520)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antioxidation and evolution: dietary restriction and alterations in molecular processes.
AU - Turturro, A.
AU - Duffy, P. H.
AU - Hart, R. W.
A2 - Basu, T.K.
A2 - Temple, N.J.
A2 - Garg, M.L.
T2 - Antioxidants in human health and disease.
Y1 - 1999///
CY - Wallingford; UK
PB - CABI Publishing
SN - 0851993346
AD - Turturro, A.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 19991409873. Publication Type: Conference paper; Book chapter. Language: English. Number of References: 5 pp. of ref. Subject Subsets: Human Nutrition
N2 - The relationship between antioxidation and dietary restriction (DR) is explored under the headings: Alteration of molecular processes by DR; Adaptive-longevity-related process theory of DR; and Consequences of DR for evolution.
KW - antioxidants
KW - evolution
KW - food restriction
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=19991409873&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bartonella henselae, B. quintana, and B. bacilliformis: historical pathogens of emerging significance.
AU - Karem, K. L.
AU - Paddock, C. D.
AU - Regnery, R. L.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2000///
VL - 2
IS - 10
SP - 1193
EP - 1205
AD - Karem, K. L.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20000508711. Publication Type: Journal Article. Language: English. Number of References: 121 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - The three primary human pathogenic bartonellae, Bartonella bacilliformis (Carrion's disease), B. henselae (cat-scratch disease), and B. quintana (trench fever), present noteworthy comparisons in the epidemiology, natural history, pathology, and host-microbe interaction that this review will briefly explore.
KW - cat scratch disease
KW - epidemiology
KW - immunology
KW - natural history
KW - pathology
KW - reviews
KW - Bartonella bacilliformis
KW - Bartonella henselae
KW - Bartonella quintana
KW - Bartonella
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Carrion's disease
KW - trench fever
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000508711&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A pooled analysis of the Iraqi and Seychelles methylmercury studies.
AU - Carrington, C. D.
AU - Bolger, P. M.
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
Y1 - 2000///
VL - 6
IS - 2
SP - 323
EP - 340
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 1080-7039
AD - Carrington, C. D.: U.S. Food and Drug Administration 200 C St SW HFS-308 Washington, DC 20204, USA.
N1 - Accession Number: 20013047381. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7439-97-6. Subject Subsets: Tropical Diseases
N2 - Several epidemiology studies have investigated the impact of maternal exposure to methylmercury (MeHg) on childhood development of the central nervous system (CNS). In the present report, data from the Iraqi episode that occurred in 1970 from contaminated grain are integrated with those from a more recent study of a population with a high fish intake in the Seychelles Islands. The latter study had many more subjects whose mercury hair levels that were much lower and more representative of levels typically found in consumers whose MeHg exposure is from fish. The age of onset of talking (AOT), the age of onset of walking (AOW) and a combined measure (CM) that integrated the two were used as common scales of MeHg effect for the two studies. The first step of the analyses involved the construction of separate two-dimensional cumulative frequency tables for each study for different groups spanning the range of hair levels and observed effect for each measure. Models were then fit to the values in the tables that were constructed from four components: (1) A dose-effect function that related hair MeHg to the effect measure; (2) a frequency distribution describing population variability; (3) parameters to represent dose-independent influences on effect; and (4) parameters to represent study dependent influences on effect. When the four submodels were assembled, a series of 1092 candidate models resulted which contained 3 to 7 parameters (e.g., slope, standard-deviation, dose-independent age of talking) whose value could be adjusted to improve the fit. After optimizing the fit of each model, a weighting algorithm that rewards for fit and penalizes for the number of parameters in the model was used to identify the best 200 models. The same algorithm was then used to assign a probability to each model in a probability tree. A twodimensional Monte-Carlo simulation using the resulting function in combination with exposure values typical of U.S. consumers yielded predicted delays in AOT, AOW, and CM attributable to fish consumption in a variable and uncertain range of 0.000 to 1 day.
KW - central nervous system
KW - children
KW - frequency distribution
KW - mercury
KW - poisoning
KW - Iraq
KW - Seychelles
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Middle East
KW - Threshold Countries
KW - West Asia
KW - Asia
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Indian Ocean Islands
KW - CNS
KW - toxicosis
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013047381&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Finite element modeling of ROPS in static testing and rear overturns.
AU - Harris, J. R.
AU - Mucino, V. H.
AU - Etherton, J. R.
AU - Snyder, K. A.
AU - Means, K. H.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2000///
VL - 6
IS - 3
SP - 215
EP - 225
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Harris, J. R.: Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 119, Morgantown, W.V 26505, USA.
N1 - Accession Number: 20013020519. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Agricultural Engineering
N2 - The current rollover protection structure (ROPS) certification standard, SAE J2194, requires either a dynamic or static testing sequence or both. Although some ROPS manufacturers perform both the dynamic and static phases of SAE J2194 testing, it is possible for a ROPS to be certified for field operation using static testing alone. This research compared ROPS deformation response from a simulated SAE J2194 static loading sequence to ROPS deformation response as a result of a simulated rearward tractor rollover. Finite element analysis techniques for plastic deformation were used to simulate both the static and dynamic rear rollover scenarios. Stress results from the rear rollover model were compared with results from simulated static testing per SAE J2194. Maximum stress values from simulated rear rollovers exceeded maximum stress values recorded during simulated static testing for half of the elements comprising the uprights. In the worst case, the static model underpredicts dynamic model results by approximately 7%. In the best case, the static model overpredicts dynamic model results by approximately 32%. These results suggest the need for additional experimental work to characterize ROPS stress levels during staged overturns and during testing according to the SAE standard.
KW - roll over protection structures
KW - safety
KW - simulation models
KW - tractors
KW - antiroll structures
KW - finite elements analysis
KW - Farm and Horticultural Structures (NN300)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013020519&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of complement fixation and commercial enzyme immunoassays for detection of antibodies to Mycoplasma pneumoniae in human serum.
AU - Thacker, W. L.
AU - Talkington, D. F.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2000///
VL - 7
IS - 5
SP - 778
EP - 780
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Thacker, W. L.: Division of Bacterial and Mycotic Diseases, U.S. Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Bldg. 5-312, Mailstop G03, Atlanta, GA 30333, USA.
N1 - Accession Number: 20003000220. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - The Meridian ImmunoCard (IC), GenBio ImmunoWELL-IgM, and Remel EIA commercial antibody tests are qualitative enzyme immunoassays that detect antibodies to Mycoplasma pneumoniae in serum. These tests were compared to an M. pneumoniae complement fixation (CF) assay, which uses a commercially available antigen component. The Meridian IC and the ImmunoWELL-IgM detect immunoglobulin M (IgM) only; the Remel EIA and the CF test detect both IgM and IgG antibodies. Detection of specific IgM antibody, which appears early in infection, can be, but is not always, indicative of a recent or current infection. Paired serum samples from 64 adult patients with probable M. pneumoniae infection were examined with each of the four tests [USA; date not given]. Thirty (47%) of the 64 acute-phase sera were IgM positive by Meridian IC, 26 (41%) were positive by Remel EIA, 24 (38%) were positive by CF, and 15 (23%) were positive by ImmunoWELL-IgM. When both the acute- and convalescent-phase serum samples from each patient were examined, 61 (95%) of the 64 patients were positive by CF, 60 patients (94%) were positive by Remel EIA, 52 patients (81%) were IgM positive by the Meridian IC, and 29 patients (45%) were IgM positive by the ImmunoWELL-IgM assay. The Meridian IC was more sensitive than the other tests for early detection of IgM antibodies. However, after examining paired serum samples, we concluded that the detection of IgM alone may not be useful for all cases of mycoplasma infection, especially in an adult population.
KW - adults
KW - antibody testing
KW - bacterial diseases
KW - complement fixation tests
KW - enzyme immunoassay
KW - human diseases
KW - IgG
KW - IgM
KW - immunodiagnosis
KW - immunological techniques
KW - USA
KW - man
KW - Mycoplasma pneumoniae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycoplasma
KW - Mycoplasmataceae
KW - Mycoplasmatales
KW - Mollicutes
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antibody detection
KW - antibody tests
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - serological diagnosis
KW - serological techniques
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003000220&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association of surface ultraviolet B radiation levels with melanoma and nonmelanoma skin cancer in United States blacks.
AU - Pennello, G.
AU - Devesa, S.
AU - Gail, M.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2000///
VL - 9
IS - 3
SP - 291
EP - 297
CY - Philadelphia; USA
PB - American Association for Cancer Research Inc.
SN - 1055-9965
AD - Pennello, G.: United States Food and Drug Administration, Center for Radiological Devices and Health, Rockville, Maryland 20850, USA.
N1 - Accession Number: 20013021600. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Tropical Diseases
N2 - Ultraviolet B (UVB) radiation exposure increases the risk of skin cancer in whites. Motivated by indications that United States geographic variation of relative skin cancer risk in blacks approaches that in whites, we used Poisson regression to estimate the risk of skin cancer in blacks as a function of average annual surface-levels of UVB radiation, measured by Robertson-Berger meters. United States data were used on deaths in 506 state economic areas, 1970-1994, and on incident cases in the nine areas of the Surveillance, Epidemiology, and End Results Program, 1973-1994. For black males, the age-adjusted relative risk of mortality for a 50% increase in UVB radiation was significantly above one for malignant melanoma, 1970-1994 (1.16; 95% confidence interval, 1.02-1.32) and nearly so for nonmelanoma skin cancer, 1970-1981 (1.18; 95% confidence interval, 1.00-1.39), for which the time period was chosen to avoid AIDS-related deaths from Kaposi's sarcoma. However, for black females, the relative risk of mortality was not significantly elevated for either skin cancer, and, for both black males and females, the relative risk of incidence was not significantly elevated for melanoma in the period 1973-1994. Incidence data on nonmelanoma skin cancer were not available. Although the public health implication is uncertain because of the much lower absolute risk of skin cancer in blacks compared with whites, the findings suggest that sunlight exposure increases skin cancer risk in blacks.
KW - exposure
KW - human diseases
KW - Kaposi's sarcoma
KW - melanoma
KW - mortality
KW - neoplasms
KW - radiation
KW - skin
KW - skin cancer
KW - solar radiation
KW - ultraviolet radiation
KW - cancers
KW - death rate
KW - dermis
KW - sunlight
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013021600&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of vitamin K1 in medical foods using matrix solid-phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2000///
VL - 13
IS - 5
SP - 765
EP - 771
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Northwest Regional Laboratory, 22201 23rd Drive, S.E., Bothell, WA 98021-4421, USA.
N1 - Accession Number: 20003016871. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 84-80-0. Subject Subsets: Dairy Science; Human Nutrition
N2 - The fortified medical foods tested included milk-based formulae. Vitamins were extracted by matrix solid-phase dispersion and quantitated by reversed-phase chromatography with fluorescence detection. Limit of detection for vitamin K1 was 6.6 pg and limit of quantitation was 22 pg on column. Mean recovery was 97.9% (n=25).
KW - analytical methods
KW - chromatography
KW - drugs
KW - foods
KW - fortification
KW - infant formulae
KW - milk
KW - phylloquinone
KW - vitamins
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - medicines
KW - pharmaceuticals
KW - phytonadione
KW - vitamin K1
KW - Milk and Dairy Produce (QQ010)
KW - Human Nutrition (General) (VV100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003016871&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA's regulation of herbs & botanicals intended for use in animal diets.
AU - Machado, J.
AU - Benz, S.
JO - FDA Veterinarian
JF - FDA Veterinarian
Y1 - 2000///
VL - 15
IS - 6
SP - 5
EP - 8
CY - Rockville; USA
PB - Food and Drug Administration
SN - 1057-6223
AD - Machado, J.: Division of Animal Feeds, CVM, Food and Drug Administration, USA.
N1 - Accession Number: 20003030233. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science; Veterinary Science; Tropical Diseases; Animal Nutrition; Aromatic & Medicinal Plants
N2 - Regulation of herbal products is discussed and a table of unapproved herbs currently marketed for use in animals is given. The article is adapted from a speech presented at the Symposium on herbs and botanicals in livestock diets: current trends, efficacy, and safety, from the ADSA-ASAS joint annual meeting, held on July 25, 2000, in Baltimore, Maryland.
KW - animal nutrition
KW - legislation
KW - livestock
KW - medicinal plants
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - rules
KW - United States of America
KW - Feed Additives (RR130)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Laws and Regulations (DD500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003030233&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary considerations to prevent loss of bone and renal function.
AU - Calvo, M. S.
JO - Nutrition
JF - Nutrition
Y1 - 2000///
VL - 16
IS - 7/8
SP - 564
EP - 566
AD - Calvo, M. S.: Clinical Research and Review Staff, Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 20001420516. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
KW - bone density
KW - bones
KW - health
KW - kidneys
KW - nutrition
KW - renal function
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - kidney function
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001420516&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Br concentration as an indication of pre-baking bromation of bread products.
AU - Cunningham, W. C.
AU - Warner, C. R.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2000///
VL - 17
IS - 2
SP - 143
EP - 148
SN - 0265-203X
AD - Cunningham, W. C.: Elemental Research Branch (HFS-338), US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20001422799. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 7726-95-6. Subject Subsets: Human Nutrition
N2 - Br concentration in bread for baked bread products was shown to be linearly proportional to the amount of Br added per kg of flour used to make the product. Br concentration in bread can be used to help identify those bread products with the greatest likelihood of containing bromate residues. Instrumental neutron activation analysis was used to determine Br in test portions of bread products from commercial bakeries, homemade bread, flour, and unbaked dough in USA. High performance liquid chromatography was used to determine the bromate residue in selected test portions.
KW - bakery products
KW - bread
KW - breadmaking
KW - bromine
KW - flours
KW - food composition
KW - food processing
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baked goods
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001422799&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic method for fumonisin B1 in sorghum syrup and corn-based breakfast cereals.
AU - Trucksess, M. W.
AU - Cho TaeHee
AU - Ready, D. E.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2000///
VL - 17
IS - 2
SP - 161
EP - 166
SN - 0265-203X
AD - Trucksess, M. W.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW Washington, DC 20204, USA.
N1 - Accession Number: 20001203864. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Maize; Medical & Veterinary Mycology; Sugar Industry
N2 - The fungus Fusarium verticillioides has been found on corn and sorghum, so it is possible that one or more of these toxins may be found in corn products such as breakfast cereals and syrup prepared from sorghum. Published methods when applied to syrups spiked with fumonisins gave low recoveries, <50%. A method was therefore developed which would be applicable to the syrup and breakfast cereals as well. Test samples were extracted with methanol-0.1 M sodium phosphate buffer (pH3)(1 + 1). The extract was diluted with water and applied to a 1 g C18 column. The column was washed with acetonitrile-water (2 + 8). Fumonisin B1 (FB1) was eluted with acetonitrile-trifluoroacetic acid (1000 + 1). The purified extract was evaporated and the toxin was derivatized with ophthaldialdehyde mercaptoethanol. The reaction mixture was resolved on a C18 liquid chromatographic column using acetonitrile-water-acetic acid (500 + 550 + 10.5) as the mobile phase at 37°C, and FB1 measured with a fluorescence detector (excitation 335 nm, emission 440 nm). Recoveries of FB1 added to samples of sorghum syrup at levels ranging from 0.1 to 1.0 µg/g were 94-132%. Recoveries of FB1 added to samples of breakfast cereal (corn flakes) at levels ranging from 0.2 to 1.6 µg/g were 96-100%. The method was applied to the analysis of 35 samples of sorghum syrup collected from 15 states in USA. One sample was found to contain FB1 at 0.12 µg/g. A total of 32 samples of breakfast cereals collected by the Food and Drug Administration inspectors from grocery stores around the Kansas City area were analysed; no FB1 was found in the breakfast cereals (<0.01µg/g). Results of this study indicated that FB1 possibly is not a problem in sorghum syrup and corn-based breakfast cereals in the US.
KW - breakfast cereals
KW - food contamination
KW - fumonisins
KW - liquid chromatography
KW - maize
KW - sorghum syrup
KW - Kansas
KW - USA
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - corn
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001203864&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effect of storage at 4°C on the stability of ampicillin residues in raw milk.
AU - Schenck, F. J.
AU - Friedman, S. L.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2000///
VL - 17
IS - 8
SP - 675
EP - 677
SN - 0265-203X
AD - Schenck, F. J.: Baltimore District Laboratory, Food and Drug Administration, 900 Madison Ave, Baltimore, MD 21201, USA.
N1 - Accession Number: 20000406414. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science; Human Nutrition
N2 - Raw milk samples collected from tanker trucks are routinely screened for β-lactam antibiotic drug residues using rapid screening tests. If drug residues are detected, the milk may be shipped on ice blocks to a laboratory for further analysis. A study was conducted to determine the stability of ampicillin in raw milk stored at +4°C in order to predict if shipping the milk would result in the degradation of ampicillin residues. Milk samples were spiked with 20 ppb ampicillin, stored at +4°C and -70°C for 1-6 days, and then analysed by HPLC with fluorescence detection. No loss of ampicillin residues was found in milk stored at +4°C for 1-6 days.
KW - ampicillin
KW - antibiotic residues
KW - cold storage
KW - drug residues
KW - raw milk
KW - screening
KW - screening tests
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000406414&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate.
AU - Shi YaPing
AU - Das, P.
AU - Holloway, B.
AU - Udhayakumar, V.
AU - Tongren, J. E.
AU - Candal, F.
AU - Biswas, S.
AU - Ahmad, R.
AU - Hasnain, S. E.
AU - Lal, A. A.
JO - Vaccine
JF - Vaccine
Y1 - 2000///
VL - 18
IS - 25
SP - 2902
EP - 2914
SN - 0264-410X
AD - Shi YaPing: Molecular Vaccine Section, Division of Parasitic Diseases, United States Department of Health and Human Service, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30341-3717, USA.
N1 - Accession Number: 20000809111. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9008-11-1. Subject Subsets: Protozoology; Tropical Diseases
N2 - A synthetic gene encoding 12 B cell epitopes, 6 T-cell proliferative epitopes, and 3 cytotoxic T lymphocyte (CTL) epitopes from 9 stage-specific antigens, representing the sporozoite, liver stage, asexual blood-stage, and sexual-stage antigens of Plasmodium falciparum, was constructed by assembling overlapping oligonucleotides followed by PCR extension and annealing. A 3-step PCR protocol using 12 long oligonucleotides was employed to generate a 1053 base-pair synthetic gene, the identity of which was confirmed by sequencing. This synthetic gene, named CDC/NII MAL VAC-1, was cloned, and the recombinant protein was expressed in the Baculovirus Expression Vector System (BEVS). The selection of malarial epitopes for inclusion in this vaccine construct was based on immunoepidemiological studies in a malaria endemic area, in vitro, and in vivo protection studies in model systems. The 41 kDa BEVS-expressed recombinant protein reacted with mouse antibodies specific for individual B cell epitopes in the vaccine construct and with sera from clinically immune Kenyan adults. An immunization study in 3 strains of mice that differ at the H-2 locus demonstrated that the BEVS-expressed recombinant protein is immunogenic; the candidate vaccine antigen induced high titre antibodies, and lymphocyte proliferative and IFN-γ responses.
KW - antigens
KW - B lymphocytes
KW - candidate vaccines
KW - cytokines
KW - cytotoxic T lymphocytes
KW - epitopes
KW - experimental infections
KW - human diseases
KW - immune response
KW - immunization
KW - interferon
KW - laboratory animals
KW - lymphocyte transformation
KW - malaria
KW - molecular genetics
KW - nucleotide sequences
KW - recombinant proteins
KW - synthetic genes
KW - T lymphocytes
KW - vaccines
KW - Kenya
KW - man
KW - mice
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - antigenic determinants
KW - antigenicity
KW - B cells
KW - biochemical genetics
KW - DNA sequences
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - T cells
KW - Host Resistance and Immunity (HH600)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000809111&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Points to consider in the development of a surrogate for efficacy of novel Japanese encephalitis virus vaccines.
AU - Markoff, L.
JO - Vaccine
JF - Vaccine
Y1 - 2000///
VL - 18
IS - Supl.2
SP - 26
EP - 32
SN - 0264-410X
AD - Markoff, L.: Laboratory of Vector-borne Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD20852-1448, USA.
N1 - Accession Number: 20000507849. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases; Public Health; Agricultural Biotechnology; Medical & Veterinary Entomology
N2 - A review of the elements for establishing a surrogate for efficacy of a new Japanese encephalitis vaccine, which included the selection of serological response correlating with efficacy and the establishment of one or more animal model systems, is presented.
KW - animal models
KW - arboviruses
KW - efficacy
KW - human diseases
KW - Japanese encephalitis
KW - reviews
KW - vaccine development
KW - vaccines
KW - Japanese encephalitis virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arthropod-borne viruses
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000507849&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycobacterium fortuitum osteomyelitis of the cuboid after nail puncture wound.
AU - Miron, D.
AU - El, A. L.
AU - Zuker, M.
AU - Lumelsky, D.
AU - Murph, M.
AU - Floyd, M. M.
AU - Brown, J. M.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2000///
VL - 19
IS - 5
SP - 483
EP - 485
SN - 0891-3668
AD - Miron, D.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 20002011065. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Public Health
KW - accidents
KW - bacterial diseases
KW - case reports
KW - children
KW - clinical aspects
KW - human diseases
KW - mycobacterial diseases
KW - nails
KW - osteomyelitis
KW - wound infections
KW - man
KW - Mycobacterium
KW - Mycobacterium fortuitum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - clinical picture
KW - mycobacterial infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002011065&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Does caloric restriction induce hormesis?
AU - Turturro, A.
AU - Hass, B. S.
AU - Hart, R. W.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000///
VL - 19
IS - 6
SP - 320
EP - 329
SN - 0144-5952
AD - Turturro, A.: Division of Biometry and Risk Assessment, National Center for Toxicological Research (NCTR), Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 20001421625. Publication Type: Journal Article. Language: English. Number of References: 72 ref. Subject Subsets: Human Nutrition
N2 - The question of whether caloric restriction (CR) is hormetic is addressed in terms of two common definitions of the term. In terms of the older definition, i.e., a growth-stimulatory effect when lower doses of a compound which resulted in growth inhibition at higher doses, CR is better characterized as a co-hormetic (i.e., a paradigm which at relatively "low doses," in combination with some stimulus, will evince increased growth (proliferation) and at higher "doses" will inhibit this increased proliferation) rather than a hormetic agent. Mechanisms such as cellular selection of cellular subpopulations, increases in receptor efficiency, and preservation of cellular proliferative potential can interact with agents and produce increased growth as long as the CR is not too severe. In terms of a broader definition, i.e., nonmonotonic dose-response behavior of a compound for any adverse response, CR appears to be hormetic, both as a result of body weight (BW) loss and other potential mechanisms. The impact of changes in BW, or frank CR, can be considered a component of every test for hormesis, and is thus capable for interaction with any other agent. The changes that BW loss (or CR) induce are so profound that any aspect of an agent's action - metabolism, pharmacokinetics, pharmacodynamics - can modulate the response of an organism to an agent. Similarly, other effects of a chemical that induce BW loss, e.g., physical activity or temperature dysregulation, can also induce dose-response curves that appear hormetic. The interaction of the hormetic agents of BW loss and CR can influence agent tests. Controlling these factors may make it possible to dissect the key components of a hormetic response. In addition, the effects of CR or BW loss appear to extrapolate well across species [Colman R, Kemnitz JW. Aging experiments using nonhuman primates. In: Yu BP (Ed), Methods in Aging Research. CRC Press, Boca Raton, FL, 1999, pp. 249-267]. Thus there is some reason to believe that these hormetic factors may be important for humans, and may already be a factor for tests of potentially adverse agents already conducted in humans.
KW - body weight
KW - food restriction
KW - growth
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hormesis
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001421625&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reduced fat diets influence α-tocopherol concentrations in plasma lipoproteins and tissues of male and female rats.
AU - Mitchell, G. V.
AU - Grundel, E.
AU - Jenkins, M. Y.
AU - Subramanium Satchithanandam
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2000///
VL - 20
IS - 1
SP - 69
EP - 78
SN - 0271-5317
AD - Mitchell, G. V.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20001411362. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 59-02-9, 8001-21-6, 1406-18-4. Subject Subsets: Human Nutrition
N2 - This study examined the effects of feeding low-fat diets containing comparable levels of vitamin E and a fat source rich in unsaturated fatty acids (sunflower oil blend). Weanling male and female Sprague Dawley rats were used in the study. Three groups of each gender (15 rats/group) were fed, for six weeks, diets containing 5.6% fat or 2.8% fat in which the dietary fat was replaced by cornstarch or a commercially available fat-free margarine product. The diets were a modification of the AIN-76 diet. Food intake was significantly increased in male and female rats fed the reduced fat diet containing the fat-free margarine. Caloric intakes and body and tissue weights of the animals were not affected by the dietary treatments. Rats fed the reduced-fat diets had higher concentrations of plasma α-tocopherol, liver α-tocopherol, and plasma HDL α-tocopherol than did rats fed the 5.6% fat diet. Female rats receiving the reduced-fat diet containing the fat-free margarine had significantly lower concentrations of total plasma and HDL α-tocopherol compared with the group fed the diet in which the fat was replaced by cornstarch. Reductions in the fat level of diets rich in unsaturated fatty acids can enhance vitamin E transport and storage when dietary vitamin E levels are maintained. The magnitude of the changes in α-tocopherol metabolism in the rat depends on gender and the dietary components used as a substitute for the fat.
KW - alpha-tocopherol
KW - diets
KW - effects
KW - fat
KW - fatty acids
KW - food intake
KW - lipoproteins
KW - liver
KW - margarine
KW - modification
KW - plasma
KW - storage
KW - sunflower oil
KW - sunflowers
KW - tissues
KW - unsaturated fatty acids
KW - vitamin E
KW - Helianthus annuus
KW - rats
KW - Helianthus
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001411362&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of intermittent exposures of aflatoxin B1 on hepatic and testicular glutathione S-transferase in rats.
AU - Sahu, S. C.
AU - Chou, M. W.
AU - Sotomayor, R. E.
AU - Hinton, D. M.
AU - Barton, C. N.
AU - O'Donnell, M. W.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2000///
VL - 20
IS - 3
SP - 215
EP - 219
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0260-437X
AD - Sahu, S. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20013042701. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology
N2 - Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B1 (AFB1). This study evaluated the effects of intermittent exposures to AFB1 on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB1 (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB1-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB1 did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB1 at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB1 exposure.
KW - aflatoxins
KW - animal models
KW - enzyme activity
KW - mycotoxins
KW - small mammals
KW - testes
KW - toxicology
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - testicles
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013042701&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The water-soluble extract of chicory reduces cholesterol uptake in gut-perfused rats.
AU - Kim MeeHye
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2000///
VL - 20
IS - 7
SP - 1017
EP - 1026
SN - 0271-5317
AD - Kim MeeHye: Department of Food Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20001419217. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 57-88-5, 9005-80-5. Subject Subsets: Sugar Industry; Human Nutrition
N2 - The direct action of soluble fibre analogues (chicory water-soluble extract and inulin) on the intestinal absorption of cholesterol was investigated in gut-perfused rats. After equilibrium, both jejunal and ileal segments were simultaneously perfused with an isotonic electrolyte solution (pH 7.4) containing cholesterol (2 mmol/L) and chicory water-soluble extract (chicory extract) or inulin (10 g/L). Each test or control solution was perfused in random sequence, with perfusion times of 30 min. Chicory extract significantly decreased cholesterol absorption by 30% (P<0.05) in the jejunum and by 41% (P<0.05) in the ileum, compared with control. Addition of inulin resulted in a significant reduction of cholesterol absorption from jejunum by 39% (P<0.05) and from ileum by 51% (P<0.05). The observed changes in cholesterol absorptions caused by chicory extract or inulin were reversible by switching to a fibre-free (control) perfusate. The reduction in intestinal absorption of cholesterol observed after perfusion of chicory extract or inulin may be due to its increased viscosity of intestinal contents.
KW - chicory
KW - cholesterol
KW - extracts
KW - fibre
KW - ileum
KW - intestinal absorption
KW - inulin
KW - jejunum
KW - viscosity
KW - Cichorium intybus
KW - rats
KW - Cichorium
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - fiber
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Synthesis and construction of a novel multiple peptide conjugate system: strategy for a subunit vaccine design.
AU - Boykins, R. A.
AU - Joshi, M.
AU - Syin, C.
AU - Dhawan, S.
AU - Nakhasi, H.
JO - Peptides
JF - Peptides
Y1 - 2000///
VL - 21
IS - 1
SP - 9
EP - 17
SN - 0196-9781
AD - Boykins, R. A.: Laboratory of Parasitic Biology and Biochemistry, Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20892, USA.
N1 - Accession Number: 20000807389. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Protozoology
N2 - The design and synthesis of a novel well-characterized multi-peptide conjugate (MPC) system containing antigens from Plasmodium falciparum and the Tat protein of HIV type-1 (HIV-1-Tat) are described. Construction of the MPC utilized Fmoc solid-phase peptide synthesis coupled with solution chemistry. In the first phase, a core template that serves as primary anchor for the synthesis and attachment of multiple antigens is synthesized. Serine(trityl) and multiple lysine branches with epsilon groups blocked during chain assembly are incorporated forming a tetrameric core. Cysteine whose side chain thiol serves to couple haloacetyl or S-protected haloacetyl peptides is added to complete assembly of the core template. Modification to the coupling solvent, addition of key amino acid derivatives (N-[1-hydroxy-4-methoxybenzyl]) in the peptide sequence allows the synthesis of base peptides on the core template with molecular mass greater than 7500 kDa. Base peptides are then reacted with high performance liquid chromatography purified haloacetyl peptides to generate multiple peptide conjugates with molecular masses of 10 to 13 kDa. MPC constructs thus formed are further characterized by matrix-assisted laser desorption-time of flight mass spectroscopy (MALDI-MS), amino acid analysis, size exclusion chromatography, and SDS-PAGE.
KW - conjugate vaccines
KW - human diseases
KW - human immunodeficiency viruses
KW - immunization
KW - malaria
KW - parasites
KW - synthetic vaccines
KW - vaccine development
KW - Human immunodeficiency virus 1
KW - man
KW - Plasmodium falciparum
KW - protozoa
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - human immunodeficiency virus
KW - human immunodeficiency virus type 1
KW - immune sensitization
KW - subunit vaccines
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Host Resistance and Immunity (HH600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multigenerational exposure to dietary genistein has no severe effects on nursing behavior in rats.
AU - Flynn, K. M.
AU - Ferguson, S. A.
AU - Delclos, K. B.
AU - Newbold, R. R.
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2000///
VL - 21
IS - 6
SP - 997
EP - 1002
CY - Little Rock; USA
PB - Intox Press
SN - 0161-813X
AD - Flynn, K. M.: Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023050112. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 446-72-0. Subject Subsets: Soyabeans; Human Nutrition
N2 - The phytoestrogen and principal isoflavone in soy, genistein, has adverse effects on reproductive physiology in rodents. Since physiology and behaviour are both sensitive to perturbations by oestrogens, genistein may produce behavioural alterations as well. This paper reports one aspect of a study in which several adult rodent behaviours will be assessed following long term multigenerational dietary exposure to genistein. Since maternal care may affect offspring behaviours in adulthood, it is important to determine the potential for genistein to affect maternal behaviour. Here, rats (F0 generation) were fed soy-free diets containing 0, 5, 100 or 500 ppm genistein (approximately 0, 0.4, 8, and 40 mg/kg/day for an adult) beginning on postnatal day (PND) 42. Two generations of offspring (F1 and F2) were continued on these diets and all treatment groups of the F3 generation were returned to 0 ppm at weaning (PND 22). In the first 3 weeks after parturition (for each generation), dams were assessed on 6 occasions for the presence of the arched back posture with at least one pup nursing. Data were analysed by 3 way repeated measures analysis of variance (ANOVA) with generation, treatment, and postnatal day as factors, and P<0.05 required for significance. There were no significant interactions among treatment, generation or day, and no overall effects of treatment or generation. As expected, there was a significant overall effect of day, with animals nursing less on later days (P<0.0001). As assessed here, these results suggest that lifelong and multigenerational exposure to dietary genistein has no severe effects on nursing behaviour in rodents.
KW - adverse effects
KW - animal models
KW - behaviour
KW - behavioural changes
KW - genistein
KW - isoflavones
KW - maternal behaviour
KW - oestrogens
KW - plant oestrogens
KW - reproduction
KW - reproductive behaviour
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - behavior
KW - behavior change
KW - biochanin A
KW - estrogens
KW - maternal behavior
KW - phytoestrogens
KW - plant estrogens
KW - reproductive behavior
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023050112&site=ehost-live&scope=site
UR - email: kflynn@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro bioactivation of N-hydroxy-2-amino-α-carboline.
AU - King, R. S.
AU - Teitel, C. H.
AU - Kadlubar, F. F.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 2000///
VL - 21
IS - 7
SP - 1347
EP - 1354
SN - 0143-3334
AD - King, R. S.: Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20001419326. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 70-18-8, 50812-37-8. Subject Subsets: Human Nutrition
KW - amines
KW - aromatic compounds
KW - biogenic amines
KW - cooking
KW - detoxification
KW - diets
KW - foods
KW - glutathione
KW - glutathione transferase
KW - in vitro
KW - inhibition
KW - liver
KW - metabolism
KW - mutagens
KW - processing
KW - variation
KW - aromatics
KW - ligandin
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology of HIV-1 in Switzerland: evidence for a silent mutation in the C2V3 region distinguishing intravenous drug users from homosexual men.
AU - Stoeckli, T. C.
AU - Steffen-Klopfstein, I.
AU - Erb, P.
AU - Brown, T. M.
AU - Kalish, M. L.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2000///
VL - 23
IS - 1
SP - 58
EP - 67
AD - Stoeckli, T. C.: Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 20002011281. Publication Type: Journal Article. Language: English. Number of References: 35 ref.
N2 - This study investigated the molecular epidemiology of HIV-1 strains found in Switzerland and determined possible genetic linkages among strains sorted by risk group or geographic region. A cross-sectional, clinic-based survey of HIV-1 molecular sequences and linked patient history from Swiss people was conducted. Specimens were collected from 215 HIV-1-infected people in HIV outpatient clinics of four tertiary referral centres (Lausanne, St. Gallen, Zurich, and Basel) between May and August 1996, mainly from homosexual men, injecting drug users (IDU), and heterosexually infected people. In addition, specimens collected between 1991 and 1995 in the HIV outpatient clinic at University of Geneva were included into this survey. These specimens were collected primarily for an ongoing, prospective cohort (Swiss HIV Cohort Study). Direct C2V3C3 sequences of the env gene were determined from 158 samples of peripheral blood mononuclear cells. Genetic data were analysed with the available patient history on each specimen. As found in other previous studies in Europe, primarily subtype B viruses were identified, whereas 7 (4%) of 158 were non-subtype B: one subtype D, 4 subtype A, and 2 subtype E. Five of 7 non-B subtypes occurred in immigrants from African or Asian countries and all 7 were found exclusively in individuals who had been infected by heterosexual contact. No significant clustering of strains within different study sites or risk groups was found. A silent mutation (LAI env 834) occurred significantly more often in IDU than in homosexual men (p<.001). Although the lack of significant clustering of strains by risk group or geographic region may result from early introduction of subtype B viruses in Switzerland, the strong association of a silent mutation with IDU suggested that, early in the epidemic, there was a unique founder virus among IDUs. The HIV epidemic in Switzerland is still predominantly caused by subtype B viruses.
KW - drug users
KW - ENV gene
KW - epidemiology
KW - genetics
KW - health centres
KW - heterosexuality
KW - HIV infections
KW - homosexuality
KW - human diseases
KW - human immunodeficiency viruses
KW - immigrants
KW - injecting drug users
KW - men
KW - molecular epidemiology
KW - mutations
KW - risk groups
KW - viral diseases
KW - Europe
KW - Switzerland
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - EFTA
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - drug abusers
KW - health centers
KW - heterosexuals
KW - homosexuals
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - i.v. drug abusers
KW - i.v. drug users
KW - intravenous drug users
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002011281&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The liquid chromatographic analysis of vitamin K1 in soy based infant formula using matrix solid phase dispersion.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 2000///
VL - 23
IS - 3
SP - 423
EP - 432
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St., Atlanta, GA 30309, USA.
N1 - Accession Number: 20001410719. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 12001-79-5, 7440-66-6. Subject Subsets: Human Nutrition; Soyabeans
N2 - A liquid chromatographic method is described for the analysis of vitamin K1 in a soya-based infant formula. The vitamins were extracted from infant formula by matrix solid phase dispersion (MSPD) and quantitated by reversed phase chromatography with fluorescence detection. Vitamin K1 was converted to the fluorescent hydroquinone with a post column zinc reductive reactor. The limit of detection was 12 pg and the limit of quantitation was 38 pg on-column. Linear response ranged from 0.70-11.0 ng/ml (r² = 0.998). Recoveries were determined on an analyte-fortified blank material for soya-based infant formula and averaged 92.5% (n=25) for vitamin K1.
KW - analytical methods
KW - infant foods
KW - infant formulae
KW - soyabeans
KW - vitamin K
KW - vitamins
KW - zinc
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - baby foods
KW - infant formula
KW - infant formulas
KW - soybeans
KW - Techniques and Methodology (ZZ900)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410719&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental evidence of host specificity of Bartonella infection in rodents.
AU - Kosoy, M. Y.
AU - Saito, E. K.
AU - Green, D.
AU - Marston, E. L.
AU - Jones, D. C.
AU - Childs, J. E.
JO - Comparative Immunology, Microbiology & Infectious Diseases
JF - Comparative Immunology, Microbiology & Infectious Diseases
Y1 - 2000///
VL - 23
IS - 4
SP - 221
EP - 238
AD - Kosoy, M. Y.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 20000509284. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - A large number of Bartonella species and genetic variants were compared for their ability to cause bacteraemia in different rodent species: the cotton rat (Sigmodon hispidus), white-footed mouse (Peromyscus leucopus), BALB/c mouse and Wistar rat. Experimental data supported field observations that host specificity can occur among certain Bartonella species and rodent species. Bacteraemia could only be readily produced in cotton rats or white-footed mice if the strains used for inoculation were originally obtained from the same species or from a phylogenetically close species. A few Bartonella colonies could be observed in the blood of some BALB/c mice by 7 days after inoculation, but no evidence of the persistence of the infection was found. Host specificity suggests the possibility of a long co-speciation of Bartonella species with their rodent hosts. Host-parasite relationships measured by the duration and level of bacteraemia and the minimal infectious dose may serve as additional criteria for classification of Bartonella isolates obtained from natural environments.
KW - bacteraemia
KW - experimental infections
KW - host parasite relationships
KW - host specificity
KW - infectivity
KW - Bartonella
KW - mice
KW - Peromyscus leucopus
KW - rats
KW - Sigmodon hispidus
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Peromyscus
KW - Sigmodontinae
KW - Sigmodon
KW - bacteremia
KW - bacterium
KW - parasite host relationships
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000509284&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Novel strategies to attenuate Leishmania donovani pathogenesis.
AU - Nakhasi, H. L.
AU - Debrabant, A.
AU - Duncan, R.
AU - Selvapandiyan, A.
AU - Padilla, A.
AU - Lee, N.
AU - Dwyer, D.
AU - Sreenivas, G.
AU - Poonam Salotra
JO - Journal of Parasitic Diseases
JF - Journal of Parasitic Diseases
Y1 - 2000///
VL - 24
IS - 2
SP - 111
EP - 117
CY - Lucknow; India
PB - Indian Society of Parasitology
SN - 0971-7196
AD - Nakhasi, H. L.: Division of Emerging and Transfusion Transmitted Diseases, US Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20023111745. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health; Protozoology
N2 - Leishmania parasites infect millions of people worldwide, with an increasing number of newly diagnosed cases every year. At present there is no vaccine available to prevent the infection. Several candidates including killed parasite, recombinant antigens and DNA based vaccines have been tested in animal models. However, none of these vaccine candidates have shown efficacy in humans. Therefore, new strategies such as a live attenuated parasite are needed to develop an efficacious Leishmania vaccine. Secretory proteins of Leishmania are thought to be putative virulence factors. In addition, proteins that have a role in parasite differentiation and growth are also thought to be involved in virulence. Towards that end we have devised two strategies which exploit parasite secretion processes and modulate expression of proteins that may have a role in growth and differentiation (1) We identified homologues of two proteins calreticulin and protein disulfide isomerase that are important for the quality control of secretion process in the endoplasmic reticulum of higher eukaryotes. Modulation of calreticulin expression in the endoplasmic reticulum of higher eukaryotes. Modulation of calreticulin expression in Leishmania resulted in alteration of secretion of one of the major secretory proteins (secretory Acid phosphatase, sAcP), which in turn affected the virulence of the parasite. (2) We have also identified several candidate genes, whose expression correlates with differentiation and growth. One such gene codes for a homologue of centrin, which has been shown to be involved in cell division in higher eukaryotes. Modulation of expression of these genes should shed light on the attenuation of Leishmania pathogenesis. Such attenuated parasites could be tested as potential candidates for a live attenuated vaccine.
KW - gene expression
KW - genes
KW - human diseases
KW - isomerases
KW - leishmaniasis
KW - pathogenesis
KW - proteins
KW - vaccine development
KW - Leishmania donovani
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - calreticulin
KW - centrin
KW - leishmaniosis
KW - protein disulfide isomerase
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023111745&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimating the national cost of treating people with HIV disease: patient, payer, and provider data.
AU - Hellinger, F. J.
AU - Fleishman, J. A.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2000///
VL - 24
IS - 2
SP - 182
EP - 188
AD - Hellinger, F. J.: Agency for Healthcare Research and Quality, 2101 East Jefferson Street, Rockville, MD 20852, USA.
N1 - Accession Number: 20002017464. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Existing estimates of the national cost of treating all people with HIV disease use data from a sample of people with HIV disease to extrapolate the cost of treating all people with HIV disease (patient-based approach). This study derives estimates using two novel approaches (i.e., payer-based and provider-based) and compares these with existing estimates. These include the Health Insurance Association of American and the American Council of Life Insurance (USA) 1996 HIV survey, the 1996 State Inpatient Databases (SID) maintained by the Agency for Healthcare Research and Quality, and the IMS America Ltd. survey of independent and chain drugstores. The cost of treating all people with HIV disease in 1996 was between $6.7 and $7.8 billion, and the average annual cost of treating a person with HIV disease was between $20 000 and $24 700. It is concluded that analysts should derive estimates of the cost of treating people with HIV disease using several different approaches.
KW - antiviral agents
KW - cost analysis
KW - drug therapy
KW - health care costs
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - costing
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002017464&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Live oral poliovirus vaccines do not contain detectable simian virus 40 (SV40) DNA.
AU - Sierra-Honigmann, A.
AU - Krause, P. R.
JO - Biologicals
JF - Biologicals
Y1 - 2000///
VL - 28
IS - 1
SP - 1
EP - 4
SN - 1045-1056
AD - Sierra-Honigmann, A.: Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Rm. 1C16, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20002013776. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9007-49-2.
N2 - Live oral poliovirus vaccines produced in the USA during 1972-96 were tested for SV40 DNA by polymerase chain reaction. No SV40 DNA sequences were found in any of the vaccine lots tested.
KW - contamination
KW - DNA
KW - human diseases
KW - poliomyelitis
KW - vaccines
KW - USA
KW - monkeys
KW - Poliovirus
KW - viruses
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - deoxyribonucleic acid
KW - human poliovirus
KW - polio
KW - sv40
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002013776&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a CHO cell-elongating factor produced by Vibrio cholerae O1.
AU - McCardell, B. A.
AU - Kothary, M. H.
AU - Hall, R. H.
AU - Sathyamoorthy, V.
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2000///
VL - 29
IS - 1
SP - 1
EP - 8
SN - 0882-4010
AD - McCardell, B. A.: U.S. Food and Drug Administration, Division of Virulence Assessment, 200 C. St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 20002017061. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Tropical Diseases
N2 - In this study, JBK 70 (a genetically manipulated cholera toxin negative strain of V. cholerae O1 biotype El Tor) was examined and found to produce a factor that is unrelated to cholera toxin, but which causes elongation of Chinese hamster ovary (CHO) cells. The partly purified CHO cell-elongating toxin (Cef) was characterized and tested in sealed infant mice, the resulting accumulation of fluid suggesting that it may be an additional enterotoxin. CHO activity on SDS-PAGE (8-25%) and IEF (pH 2.5-5.0) gels was associated with a single band at 85 kDa and a pI of 3.8 respectively. Automated Edman degradation of gel-purified protein revealed a unique amino terminal sequence. Based on the unique molecular mass, N-terminal sequence and activity on CHO cells, this factor is thought not to be zonula occludens toxin (Zot) or accessory cholera enterotoxin (Ace) or the Hly A haemolysin. Partly purified Cef did not produce an increase in cyclic AMP or prostaglandin E<S2>2</S2> levels in CHO cells, suggesting that it had a different mechanism of action to that of cholera toxin.
KW - animal models
KW - bacterial toxins
KW - laboratory animals
KW - pathology
KW - toxins
KW - mice
KW - Vibrio cholerae
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002017061&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic and immunologic characterization of a novel serotype 4, 15 strain of Neisseria meningitidis.
AU - Bash, M. C.
AU - Lynn, F.
AU - Concepcion, N. F.
AU - Tappero, J. W.
AU - Carlone, G. M.
AU - Frasch, C. E.
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
Y1 - 2000///
VL - 29
IS - 3
SP - 169
EP - 176
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0928-8244
AD - Bash, M. C.: Division of Bacterial, Allergenic and Parasitic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20003021660. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Tropical Diseases
N2 - The porin proteins of Neisseria meningitidis are important components of outer membrane protein (OMP) vaccines. The class 3 porin gene, porB, of a novel serogroup B, serotype 4, 15 isolate from Chile (Ch501) was found to be VR1-4, VR2-15, VR3-15 and VR4-15 by porB variable region (VR) typing. Rabbit immunization studies using outer membrane vesicles revealed immunodominance of individual PorB (class 3) VR epitopes. The predominant anti-Ch501 PorB response was directed to the VR1 epitope. Anti-PorB VR1 mediated killing was suggested by the bactericidal activity of Ch501 anti-sera against a type 4 strain not expressing PorA or class 5 OMPs. Studies that examine the molecular epidemiology of individual porB VRs, and the immune responses to PorB epitopes, may contribute to the development of broadly protective group B meningococcal vaccines.
KW - characterization
KW - epitopes
KW - immune response
KW - immunology
KW - vesicles
KW - Chile
KW - Neisseria meningitidis
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - antigenic determinants
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - Meningococcus
KW - outer membrane proteins
KW - serogroups
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003021660&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunogenicity of a heptavalent pneumococcal conjugate vaccine in Apache and Navajo Indian, Alaska Native, and non-Native American children aged <2 years.
AU - Miernyk, K. M.
AU - Parkinson, A. J.
AU - Rudolph, K. M.
AU - Petersen, K. M.
AU - Bulkow, L. R.
AU - Greenberg, D. P.
AU - Ward, J. I.
AU - Brenneman, G.
AU - Reid, R.
AU - Santosham, M.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2000///
VL - 31
IS - 1
SP - 34
EP - 41
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Miernyk, K. M.: Arctic Investigations Program, US Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service 4055 Tudor Centre Dr., Anchorage, AK 99508, USA.
N1 - Accession Number: 20003003856. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 308067-58-5. Subject Subsets: Plant Breeding; Public Health
N2 - High rates of invasive pneumococcal disease have been described among infants living in various Native American communities. In this study, we evaluated the immunogenicity of a 7-valent pneumococcal vaccine consisting of serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F covalently linked to the outer membrane protein complex of Neisseria meningitidis in 34 Apache and Navajo Indian, 30 Alaska Native, and 32 non-Native American children. They were recruited from well-baby clinics in USA during 1993-94. The vaccine was administered at ages 2, 4, and 6 months; a booster dose was given at age 15 months. Levels of serotype-specific IgG were measured by a standardized ELISA. The responses after 3 primary doses of vaccine were similar in all 3 groups of children, except for those to serotypes 14 and 23F. One month after the booster dose, geometric mean concentrations (GMCs) of serotype-specific IgG antibodies increased significantly in all 3 groups of children, compared with GMCs of IgG antibodies to pneumococcal serotypes before the booster dose.
KW - antigens
KW - Apache indians
KW - bacterial diseases
KW - children
KW - conjugate vaccines
KW - IgG
KW - immune response
KW - immunization
KW - Navajo indians
KW - serotypes
KW - vaccination
KW - Alaska
KW - USA
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antigenicity
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Meningococcus
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003003856&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antiatherogenic effect of the extract of Allium victorialis on the experimental atherosclerosis in the rabbit and transgenic mouse.
AU - Kim TaeGyun
AU - Kim SeungHee
AU - Kang SoegYoun
AU - Jung KiKyung
AU - Choi DonHa
AU - Park YongBok
AU - Ryu JongHoon
AU - Han HyungMee
JO - Korean Journal of Pharmacognosy
JF - Korean Journal of Pharmacognosy
Y1 - 2000///
VL - 31
IS - 2
SP - 149
EP - 156
AD - Kim TaeGyun: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20000316452. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 25 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Agricultural Biotechnology; Aromatic & Medicinal Plants
N2 - Atherosclerosis is emerging as one of the major causes of death in Korea as well as Western societies. In the present study, hypocholesterolaemic and antiatherogenic effects of the ethanol extract of A. victorialis were investigated using the conventional rabbit and the cholesteryl ester transfer protein (CETP)-transgenic mouse model. Hypercholesterolaemia was induced by feeding high cholesterol diet to the animals for 30 days and they were then fed with high cholesterol diet containing 0.5% of A. victorialis extract for an additional 30 (or 40) days. In the experiment using rabbits, treatment with A. victorialis significantly decreased plasma total cholesterol, low density lipoprotein (LDL)-cholesterol, triglyceride levels and lipid peroxidation compared with the control. Total cholesterol contents in the liver and the heart were also significantly decreased. Lipid staining of the aorta isolated from rabbits showed that treatment with A. victorialis decreased formation of atheromatous plaques on the intima of the aorta. In the experiment employing CETP transgenic mouse model, treatment with A. victorialis decreased the levels of plasma total cholesterol and tissue triglyceride levels in the heart. The ethanol extract of A. victorialis lowered serum cholesterol levels, tissue lipid contents and the accumulation of cholesterol in the artery.
KW - animal models
KW - blood composition
KW - cardiovascular system
KW - cholesterol
KW - hypocholesterolaemic properties
KW - lipid peroxidation
KW - lipoproteins
KW - medicinal plants
KW - plant extracts
KW - transgenics
KW - triacylglycerols
KW - Korea Republic
KW - mice
KW - rabbits
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - Allium
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - Allium victorialis
KW - circulatory system
KW - drug plants
KW - hypocholesterolemic properties
KW - medicinal herbs
KW - officinal plants
KW - South Korea
KW - triglycerides
KW - Plant Science (General) (FF000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000316452&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical and radiological features of South African patients with tuberculomas of the brain.
AU - Thonell, L.
AU - Pendle, S.
AU - Sacks, L.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2000///
VL - 31
IS - 2
SP - 619
EP - 620
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Thonell, L.: Center for Drug Evaluation and Research, Division of Special Pathogens, 9201 Corporate Blvd., HFD 590, Rockville, MD 20850, USA.
N1 - Accession Number: 20003015440. Publication Type: Journal Article. Language: English. Number of References: 9 ref Subject Subsets: Tropical Diseases
N2 - Intracranial tuberculomas are a rare complication of tuberculosis that typically occurs in immunocompromised patients not treated previously for tuberculosis. We identified tuberculomas in 12 patients (11 of whom were infected with human immunodeficiency virus) at a hospital in Johannesburg, South Africa. Responses to antituberculous therapy were good, often despite the presence of large lesions, and surgery was not considered necessary in any of the patients.
KW - case reports
KW - clinical aspects
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - tuberculosis
KW - South Africa
KW - man
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - Threshold Countries
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - tuberculoma
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monitoring research for residual pesticides as endocrine disruptors in natural medicines (I).
AU - Cho JungHee
AU - Kim DoHoon
AU - Kim HyeSoo
AU - Oh MiHyune
AU - Kang InHo
AU - Shim YoungHun
AU - Hwang WanKyun
AU - Myung SeongWun
AU - Choi ByungKi
JO - Korean Journal of Pharmacognosy
JF - Korean Journal of Pharmacognosy
Y1 - 2000///
VL - 31
IS - 4
SP - 455
EP - 458
CY - Kwangju; Korea Republic
PB - Korean Society of Pharmacognosy
SN - 0253-3073
AD - Cho JungHee: Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20013048399. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 15 ref. Subject Subsets: Aromatic & Medicinal Plants; Forestry; Forest Products; Postharvest Research; Agroforestry; Horticultural Science
N2 - Glycyrrhiza Root, Cinnamon Bark, Pueraria Root, Polygonatum Rhizome, Jujube, Schizandra [Schisandra] Fruit, Lycium Fruit, Liriope Tuber, Eucommia Bark, Peony Root, Korean Angelica, Dioscorea Rhizome, Cnidium Rhizome, Cassia Seed, Platycodon Root, Cornus Fruit, Mentha Herb, Epimedium Herb, Bupleurum Root, and Ginger samples collected from Korea Republic and China were analysed using GC-ECD and GC-MSD methods to confirm the identity of pesticide residues in each sample.
KW - analytical methods
KW - bark
KW - chemical composition
KW - cinnamon
KW - endocrine diseases
KW - fruits
KW - ginger
KW - herbal drugs
KW - medicinal plants
KW - non-wood forest products
KW - pesticide residues
KW - pesticides
KW - rhizomes
KW - roots
KW - traditional medicines
KW - tubers
KW - yams
KW - China
KW - Korea Republic
KW - Angelica
KW - Bupleurum
KW - Cassia
KW - Cinnamomum
KW - Cnidium
KW - Cornus
KW - Dioscorea
KW - Epimedium
KW - Eucommia
KW - Glycyrrhiza
KW - Liriope
KW - Lycium
KW - Mentha
KW - Paeonia
KW - Platycodon
KW - Polygonatum
KW - Pueraria
KW - Schisandra
KW - Zingiber
KW - Ziziphus jujuba
KW - Ziziphus mauritiana
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Caesalpinioideae
KW - Fabaceae
KW - Fabales
KW - Lauraceae
KW - Laurales
KW - Cornaceae
KW - Cornales
KW - Dioscoreaceae
KW - Liliales
KW - Violales
KW - Berberidaceae
KW - Ranunculales
KW - Eucommiaceae
KW - Eucommiales
KW - Papilionoideae
KW - Liliaceae
KW - monocotyledons
KW - Solanaceae
KW - Solanales
KW - Lamiaceae
KW - Lamiales
KW - Paeoniaceae
KW - Dilleniales
KW - Campanulaceae
KW - Campanulales
KW - Schisandraceae
KW - Illiciales
KW - Zingiberaceae
KW - Zingiberales
KW - Ziziphus
KW - Rhamnaceae
KW - Rhamnales
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - analytical techniques
KW - Araliales
KW - drug plants
KW - endocrine disorders
KW - herbal medicines
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - Paeoniales
KW - People's Republic of China
KW - South Korea
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-wood Forest Products (KK540)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of gentamicin and neomycin in milk by weak cation-exchange extraction and electrospray ionization/ion trap tandem mass spectrometry.
AU - Heller, D. N.
AU - Clark, S. B.
AU - Righter, H. F.
JO - Journal of Mass Spectrometry
JF - Journal of Mass Spectrometry
Y1 - 2000///
VL - 35
IS - 1
SP - 39
EP - 49
AD - Heller, D. N.: US Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
N1 - Accession Number: 20000404506. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 1403-66-3, 1405-41-0, 1404-04-2. Subject Subsets: Veterinary Science; Human Nutrition; Dairy Science; Veterinary Science
N2 - A new procedure for the confirmation of 2 aminoglycoside antibiotics in milk was developed and validated. This work is among the early applications of ion trap mass spectrometry for regulatory methodology, and incorporates a novel weak cation-exchange extraction. The procedure was validated for the confirmation of both gentamicin and neomycin at ≥30 ng/ml. Milk is first treated with acid and centrifuged. The supernatant, excluding the fat layer, is buffered with sodium citrate to neutral pH. The extract is applied to a weak cation-exchange solid-phase extraction column. Aminoglycosides are eluted with acidified methanol. Following separation by ion-pair liquid chromatography, analytes are ionized with an electrospray interface. Protonated molecular ions are selectively stored in an ion trap mass spectrometer, then collisionally dissociated to yield unique product ion spectra. Confirmation is based on matching spectral responses between samples and comparison standards consisting of a bona fide standard spiked into control extracts. Method performance was demonstrated with replicate samples of control milk, fortified milk, and milk containing incurred residues of each compound.
KW - analytical methods
KW - antibiotic residues
KW - antibiotics
KW - cation exchange
KW - drug residues
KW - extracts
KW - gentamicin
KW - mass spectrometry
KW - methodology
KW - milk
KW - neomycin
KW - standards
KW - analytical techniques
KW - methods
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatography - high resolution selected-ion mass spectrometric identification of trace 21:0 and 20:2 fatty acids eluting with conjugated linoleic acid isomers.
AU - Roach, J. A. G.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
AU - Mossoba, M. M.
AU - Eulitz, K.
AU - Ku, Y.
JO - Lipids
JF - Lipids
Y1 - 2000///
VL - 35
IS - 7
SP - 797
EP - 802
SN - 0024-4201
AD - Roach, J. A. G.: U.S. Food and Drug Administration, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001420711. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 60-33-3, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition
N2 - High-resolution selected-ion recording (SIR) of the exact molecular ion mass was used to confirm unambiguously the presence of conjugated linoleic acid (CLA) derivatives in biological matrices and standard mixtures and to differentiate non-CLA derivatives from CLA derivatives in the CLA region of the gas chromatogram. The success of this method was based on the selectivity of the SIR technique and its sensitivity, which was comparable to that of flame-ionization detection. A minor fatty acid methyl ester (FAME) was identified as methyl heneicosanoate (21:0), and six isomers of 20:2 FAME were found to elute in the CLA region. Isomerization of a standard CLA mixture resulted in a non-CLA flame-ionization response eluting in the CLA region of the gas chromatogram. It is therefore recommended that the identification of minor CLA isomers in natural products or biological matrices should include their direct confirmation by mass spectrometry.
KW - analysis
KW - analytical methods
KW - conjugated linoleic acid
KW - derivatives
KW - fatty acids
KW - isomers
KW - linoleic acid
KW - mass spectrometry
KW - mixtures
KW - techniques
KW - analytical techniques
KW - Human Nutrition (General) (VV100)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantities of Yersinia pestis in fleas (Siphonaptera: Pulicidae, Ceratophyllidae, and Hystrichopsyllidae) collected from areas of known or suspected plague activity.
AU - Engelthaler, D. M.
AU - Gage, K. L.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 2000///
VL - 37
IS - 3
SP - 422
EP - 426
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-2585
AD - Engelthaler, D. M.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013046773. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - We used a quantitative competitive polymerase chain reaction (PCR) (QC-PCR) to determine bacterial loads in 669 fleas collected in areas of confirmed and suspected plague epizootics. Fleas were collected out of rodent burrows (67.9%) and off of captured animals (24.1%) and rodent carcasses (8.1%). An initial PCR screening assay indicated that 12.1% (81/669) of all fleas were positive for Yersinia pestis. Fleas collected from burrows had significantly lower (χ2=264.9, P<0.0001) infection rates (6.8%) but significantly higher (Student t-test, P<0.0001) bacterial loads (mean=105.6Y. pestis per flea) than fleas collected off of rodent carcasses (infection rate=92.6%; mean bacterial load=104,8Y. pestis per flea). None of the fleas collected off of captured animals were positive for Y. pestis by PCR, although seven of the 176 captured animals were serologically positive for Y. pestis.
KW - assays
KW - plague
KW - screening
KW - Siphonaptera
KW - Yersinia pestis
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - epizootics
KW - screening tests
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - La Crosse encephalitis virus habitat associations in Nicholas County, West Virginia.
AU - Nasci, R. S.
AU - Moore, C. G.
AU - Biggerstaff, B. J.
AU - Panella, N. A.
AU - Liu, H. Q.
AU - Karabatsos, N.
AU - Davis, B. S.
AU - Brannon, E. S.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 2000///
VL - 37
IS - 4
SP - 559
EP - 570
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-2585
AD - Nasci, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013136495. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Aedes triseriatus population density patterns and La Crosse encephalitis virus infection rates were evaluated in relation to a variety of habitat parameters over a 14-wk period. Ovitraps and landing collections were used in a La Crosse virus-enzootic area in Nicholas County, West Virginia, USA. Study sites were divided into categories by habitat type and by proximity to the residences of known La Crosse encephalitis cases. Results demonstrated that A. triseriatus population densities were higher in sugar maple/red maple habitats than in hemlock/mixed hardwood habitats or in a site characterized by a large number of small red maple trees. Sites containing artificial containers had higher population densities than those without. La Crosse virus minimum infection rates in mosquitoes collected as eggs ranged from 0.4/1000 to 7.5/1000 in the 12 study sites, but did not differ significantly among sites regardless of habitat type or proximity to human case residences. La Crosse virus infection rates in landing A. triseriatus mosquitoes ranged from 0.0/1,000 to 27.0/1000. La Crosse virus was also isolated from host-seeking A. canadensis in two study sites, at rates similar to those found in the A. triseriatus populations. The A. triseriatus oviposition patterns and La Crosse virus infection rates suggest that this mosquito species disperses readily in the large woodlands of central West Virginia. The La Crosse enzootic habitats in Nicholas County, West Virginia, are contrasted with those studied in other geographic regions where La Crosse virus is found.
KW - encephalitis
KW - geographical distribution
KW - habitats
KW - oviposition
KW - population density
KW - USA
KW - West Virginia
KW - Aedes
KW - Aedes triseriatus
KW - Culicidae
KW - La Crosse virus
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - encephalomyelitis
KW - mosquitoes
KW - Ochlerotatus
KW - Ochlerotatus triseriatus
KW - United States of America
KW - Biological Resources (Animal) (PP710)
KW - Behaviour (Wild Animals) (YY500) (New March 2000)
KW - Animal Ecology (ZZ332)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013136495&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vector competence of Ixodes muris (Acari: Ixodidae) for Borrelia burgdorferi.
AU - Dolan, M. C.
AU - Lacombe, E. H.
AU - Piesman, J.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 2000///
VL - 37
IS - 5
SP - 766
EP - 768
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-2585
AD - Dolan, M. C.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013085484. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The vector competence of Ixodes muris was determined for Borrelia burgdorferi, the aetiologic agent of Lyme disease. Larval I. muris were fed on ICR outbred mice infected with the B-31 laboratory strain of B. burgdorferi. Replete larvae, at 5 days after feeding, were assayed for infection by culture in Barbour-Stoner-Kelly (BSK-H) media. Results revealed that infection frequency in I. muris replete larvae was 66%. Resultant nymphs were fed on naive ICR outbred mice to determine the ability of I. muris to transmit infection. Infection frequency in fed nymphs declined to 38% and only one of 5 mice was positive for B. burgdorferi on ear biopsy culture. We demonstrated that I. muris is capable of acquiring and transmitting B. burgdorferi, but is a relatively poor vector compared with I. scapularis.
KW - disease transmission
KW - disease vectors
KW - experimental infections
KW - laboratory animals
KW - larvae
KW - Lyme disease
KW - nymphs
KW - vector competence
KW - Borrelia burgdorferi
KW - Ixodes
KW - mice
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ixodes
KW - bacterium
KW - Ixodes muris
KW - lyme borreliosis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Zoology of Wild Animals (Vertebrates and Invertebrates) (General) (YY000) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Slip and fall-related injuries in relation to environmental cold and work location in above-ground coal mining operations.
AU - Bell, J. L.
AU - Gardner, L. I.
AU - Landsittel, D. P.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2000///
VL - 38
IS - 1
SP - 40
EP - 48
CY - New York; USA
PB - Wiley-Liss
SN - 0271-3586
AD - Bell, J. L.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road, M/S P1133, Morgantown, WV 26505, USA.
N1 - Accession Number: 20013080880. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - The association between slip and fall-related injuries and environmental temperature was examined for mostly enclosed (inside vehicles, machinery, or buildings), outdoor (outside, not enclosed), and enclosed/outdoor jobs in the coal mining industry to see if differences existed among the three work locations that had varying exposure to cold temperatures. Temperature data from the National Climatic Data Center and injury data from the Mine Safety and Health Administration were evaluated from 1985-90 for seven states (Illinois, Indiana, Kentucky, Ohio, Pennsylvania, Virginia and West Virginia) in the USA. Proportionate methods were used to examine the relationship between slips and falls and temperature. Proportionate injury ratios of slips and fall-related injuries increased as temperature declined for all three work locations. Proportion of slips and fall-related injuries that occurred while running/walking increased with declining temperature, with the ground outside as the most common source of these injuries. It is concluded that outside movement becomes a greater hazard at freezing temperatures for workers in all locations, not just outdoor workers. Any intervention methods geared toward reducing injury incidents facilitated by cold weather must also be directed toward workers who spend time in more enclosed locations.
KW - accidents
KW - coal workers
KW - environmental temperature
KW - falls
KW - miners
KW - occupational hazards
KW - trauma
KW - Illinois
KW - Indiana
KW - Kentucky
KW - Ohio
KW - USA
KW - Virginia
KW - West Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - Appalachian States of USA
KW - Southern States of USA
KW - East South Central States of USA
KW - South Atlantic States of USA
KW - traumas
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013080880&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effect of maternal exposure to flaxseed on spermatogenesis in F1 generation rats.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Olejnik, N.
AU - Rorie, J. I.
AU - Scott, M.
AU - Wiesenfeld, P.
AU - Babu, U. S.
AU - O'Donnell, M.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2000///
VL - 38
IS - 4
SP - 325
EP - 334
SN - 0278-6915
AD - Sprando, R. L.: Division of Toxicological Research, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20001416476. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9002-67-9, 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8, 15262-86-9. Subject Subsets: Human Nutrition
N2 - Pregnant Sprague-Dawley rats were exposed to a flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 (0% flaxseed control) diet throughout gestation and until their offspring were weaned. After weaning, F1 generation males were placed in the same diet treatment groups as their mothers for 70 days. Statistically significant differences were not observed between either low-dose or high-dose flaxseed and flaxmeal-treated animals and the 0% flaxseed control animals for testis weights, homogenization resistant spermatid counts, daily sperm production rates, epididymal weights, seminal vesicle weights, seminiferous tubule fluid testosterone concentrations and the percentage of sperm abnormalities. The following statistically significant differences were observed when treated groups and the 0% flaxseed control groups were compared: (1) increases in serum LH in the 20% and 40% flaxseed treatment groups and in serum LH and testosterone in the 26% flaxmeal treatment group; (2) increases in the cauda epididymal weight from the 20% and 40% flaxseed groups; (3) increases in cauda epididymal sperm numbers/g epididymis from the 20% and 40% flaxseed and the 13% and 26% flaxmeal treatment groups; (4) a decrease in prostatic weight from the 20% flaxseed and 13% and 26% flaxmeal treatment groups. Prostate weight in the 40% flaxseed treatment group was lower but not statistically significantly different than the 0% flaxseed control group. Histological effects on spermatogenesis were not observed in either the control group, flaxmeal or the flaxseed treated groups.
KW - flax
KW - LH
KW - linseed
KW - linseed oilmeal
KW - males
KW - pregnancy
KW - prostate
KW - spermatogenesis
KW - testes
KW - testosterone
KW - weaning
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - gestation
KW - linseed cake
KW - luteinizing hormone
KW - testicles
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416476&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transfer of erythromycin resistance from poultry to human clinical strains of Staphylococcus aureus.
AU - Khan, S. A.
AU - Nawaz, M. S.
AU - Khan, A. A.
AU - Cerniglia, C. E.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2000///
VL - 38
IS - 5
SP - 1832
EP - 1838
SN - 0095-1137
AD - Khan, S. A.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20002011603. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 114-07-8, 60-54-8, 64-75-5.
N2 - The transfer of ermA and ermC genes, the two most common resistance determinants of erythromycin resistance, was studied with Luria-Bertani broth in the absence of additional Ca2+ or Mg2+ ions. Fifteen human and five poultry isolates of Staphylococcus aureus, which were resistant to erythromycin but carried different genetic markers for erythromycin resistance, were used for conjugation. Since both the donors (Amps-Tetr) and recipients (Ampr-Tets) were resistant to erythromycin, the transconjugants were initially picked up as ampicillin- and tetracycline-resistant colonies. The resistance transfer mechanisms of the chromosomally located erythromycin rRNA methylase gene ermA and the plasmid-borne ermC gene were monitored by a multiplex PCR and gene-specific internal probing assay. Four groups of transconjugants, based upon the transfer of the ermA and/or ermC gene, were distinguished from each other by the use of this method. Selective antibiotic screening revealed only one type of transconjugant that was resistant to ampicillin and tetracycline. A high frequency of transfer (4.5×10-3) was observed in all of the 23 transconjugants obtained, and the direction of tetracycline and erythromycin resistance marker transfer was determined to be from poultry to clinical isolates. The transfers of the ermA and ermC genes were via transposition and transformation, respectively.
KW - ampicillin
KW - antibiotics
KW - colonies
KW - drug resistance
KW - erythromycin
KW - genes
KW - genetic markers
KW - genetic transformation
KW - human diseases
KW - ions
KW - plasmids
KW - polymerase chain reaction
KW - poultry
KW - ribosomal RNA
KW - strains
KW - tetracycline
KW - transposition
KW - USA
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - bacterium
KW - domesticated birds
KW - gene transposition
KW - PCR
KW - rRNA
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002011603&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid identification of Yersinia enterocolitica in blood by the 5′ nuclease PCR assay.
AU - Sen, K.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2000///
VL - 38
IS - 5
SP - 1953
EP - 1958
SN - 0095-1137
AD - Sen, K.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-320, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20002011611. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - Yersinia enterocolitica accounts for 50% of the clinical sepsis episodes caused by the transfusion of contaminated red blood cells. A 5′ nuclease TaqMan PCR assay was developed to detect Y. enterocolitica in blood. Primers and a probe based on the nucleotide sequence of the 16S rRNA gene from Y. enterocolitica were designed. Whole-blood samples were spiked with various numbers of Y. enterocolitica cells, and total chromosomal DNA was extracted. When the TaqMan PCR assay was performed, as few as six bacteria spiked in 200 µl of blood could be detected. The assay was specific and did not detect other Yersinia species. The TaqMan assay is easy to perform, takes 2 h, and has the potential for use in the rapid detection of Y. enterocolitica contamination in stored blood units.
KW - assays
KW - blood cells
KW - blood transfusion
KW - contamination
KW - detection
KW - diagnostic techniques
KW - DNA
KW - erythrocytes
KW - genes
KW - human diseases
KW - identification
KW - nucleases
KW - nucleotide sequences
KW - polymerase chain reaction
KW - ribosomal RNA
KW - sepsis
KW - man
KW - Yersinia enterocolitica
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - blood red cells
KW - deoxyribonucleic acid
KW - DNA sequences
KW - PCR
KW - red blood cells
KW - rRNA
KW - Yersinia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002011611&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extraction-free, filter-based template preparation for rapid and sensitive PCR detection of pathogenic parasitic protozoa.
AU - Orlandi, P. A.
AU - Lampel, K. A.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2000///
VL - 38
IS - 6
SP - 2271
EP - 2277
SN - 0095-1137
AD - Orlandi, P. A.: Division Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20000808108. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Protozoology
N2 - An extraction-free, filter-based protocol was developed to prepare DNA templates for use in PCR to identify Cyclospora cayetanensis and Cryptosporidium parvum oocysts and microsporidia spores. This method required only minimal preparation to partially purify and concentrate isolates prior to filter application. DNA template preparation was rapid, efficient and reproducible. As few as 3 to 10 parasites could be detected by PCR from direct application to the filters. As few 10 to 50 Encephalitozoon intestinalis spores could be detected when seeded in a 100-µl faecal sample and 10 to 30 Cyclospora cayetanensis oocysts could be detected per 100 g of fresh raspberries. This protocol can easily be adapted to detect parasites from a wide variety of food, clinical and environmental samples and can be used in multiplex PCR applications.
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - foodborne diseases
KW - human diseases
KW - parasites
KW - polymerase chain reaction
KW - spores
KW - techniques
KW - waterborne diseases
KW - Cryptosporidium parvum
KW - Cyclospora cayetanensis
KW - man
KW - Microspora
KW - Protozoa
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cyclospora
KW - Eimeriidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - PCR
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000808108&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Testing the potential of flaxseed to affect spermatogenesis: morphometry.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Wiesenfeld, P.
AU - Babu, U. S.
AU - Rees, C.
AU - Black, T.
AU - Olejnik, N.
AU - Rorie, J.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2000///
VL - 38
IS - 10
SP - 887
EP - 892
SN - 0278-6915
AD - Sprando, R. L.: Division of Toxicological Research, Center for Food Safety Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Beltsville, MD 20708, USA.
N1 - Accession Number: 20001421360. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Animal Breeding; Human Nutrition
N2 - Quantitative information was collected on male reproductive effects of maternal and post-natal dietary exposure to flaxseed (20 or 40%), flaxmeal (13 or 26%) or standard NIH AIN-93 feed (0% flaxseed control). Measurements were made on the testes of F1 generation male rats (1) whose mothers were exposed to the diets designated above, and (2) who, after weaning, were placed on the same diet as their mothers for an additional 70 days. The seminiferous tubules comprised 86%, 84%, 84%, 84% and 85% of the total testis volume while the interstitial space comprised 12%, 14%, 14%, 14%, 13% of the total testis volume for the 0% flaxseed/flaxmeal, 20% flaxseed, 13% flaxmeal, 40% flaxseed and 26% flaxmeal groups, respectively. Statistically significant decreases in the absolute volume of the seminiferous tubules were observed in the 20% and 40% flaxseed-treated groups when these groups were compared to controls. Borderline statistically significant differences were also observed when Sertoli cell nucleolar number per tubular cross-section were compared in the 13% flaxmeal and 20% flaxseed treatment groups. These effects were not considered biologically significant because other parameters of male reproductive function appeared normal. Overall, the quantitative information obtained suggests that exposure to flaxseed/flaxmeal at the doses used in this study does not adversely affect testis structure or spermatogenesis in the rat.
KW - animal models
KW - dams (mothers)
KW - diets
KW - flax
KW - linseed
KW - linseed oilmeal
KW - male fertility
KW - rat feeding
KW - reproduction
KW - spermatogenesis
KW - testes
KW - weaning
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - linseed cake
KW - testicles
KW - Animal Models of Human Nutrition (VV140)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001421360&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes.
AU - Ross, I. A.
AU - Johnson, W.
AU - Sapienza, P. P.
AU - Kim, C. S.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2000///
VL - 38
IS - 11
SP - 1005
EP - 1011
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Ross, I. A.: Division of Toxicological Research (HFS-506), Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20003010533. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 56-86-0. Subject Subsets: Human Nutrition
N2 - Pronounced glutamic acid uptake was observed after only 15 min with glutamate concentrations of 60 nmol/mg protein when astrocytes were incubated with 1 mM glutamic acid. The uptake increased with time to a steady-state glutamate level of above 160 nmol/mg protein by 45 min. The uptake was energy dependent. Reduced temperature (0°C) and ouabain (100 µM) inhibited uptake by 86.7% (P<0.001; n=18) and 84.4% (P<0.001; n=18), respectively, when compared with controls. After exposure of astrocytes to glutamate (1 mM) in the incubation medium, in the presence of domoic acid (10 and 100 µM) at 5 and 60 min, domoic acid (10 µM) raised glutamate uptake by 64.0% (P<0.05; n=34) at 5 min but decreased glutamate uptake by 47.8% (P<0.01; n=19) at 60 min compared with controls. A higher dose of domoic acid (100 µM) decreased glutamate uptake by 49.6% (P<0.01; n=20) and 61.3% (P<0.001; n=20) at 5 and 60 min, respectively, compared with controls. This study suggests that domoic acid may induce neurotoxicity because of the failure of astrocytes to remove extracellular glutamate. This may contribute to excitotoxic injury.
KW - animal models
KW - cell cultures
KW - glutamates
KW - glutamic acid
KW - neurotoxicity
KW - seafoods
KW - toxicity
KW - toxins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - domoic acid
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003010533&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Congenital malaria: diagnosis and therapy.
AU - Viraraghavan, R.
AU - Jantausch, B.
T2 - Clinical Pediatrics
JO - Clinical Pediatrics
JF - Clinical Pediatrics
Y1 - 2000///
VL - 39
IS - 1
SP - 66
EP - 67
CY - Glen Head; USA
PB - Westminster Publications
SN - 0009-9228
AD - Viraraghavan, R.: Division of Anti-Infective Drug Products, Food and Drug Administration, 9201 Corporate Blvd., Room S316, HFD-520, Rockville, MD 20857, USA.
N1 - Accession Number: 20003005580. Publication Type: Correspondence. Language: English. Number of References: 5 ref. Subject Subsets: Public Health; Protozoology; Tropical Diseases
N2 - The case is reported of a full-term male infant who presented in the USA with jaundice and hepatosplenomegaly at 5 weeks of age. The infant's mother was from Liberia and had had multiple episodes (>15) of malaria. She had had malaria twice during her pregnancy, and had emigrated to the USA at 6 months' gestation. A blood film from the infant revealed Plasmodium falciparum ring forms and gametocytes (4.4% parasitaemia). 49 cases of congenital malaria have been reported in the USA since 1950: diagnosis and therapy are briefly discussed.
KW - case reports
KW - children
KW - congenital infection
KW - diagnosis
KW - drug therapy
KW - human diseases
KW - imported infections
KW - infants
KW - malaria
KW - Liberia
KW - USA
KW - man
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - prenatal infection
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003005580&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The development of science-based food safety regulations in the United States.
AU - Buchanan, R. L.
JO - Irish Journal of Agricultural and Food Research
JF - Irish Journal of Agricultural and Food Research
Y1 - 2000///
VL - 39
IS - 2
SP - 331
EP - 342
SN - 0791-6833
AD - Buchanan, R. L.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C-Street, SW, Washington, DC, 20204, USA.
N1 - Accession Number: 20001416394. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The safe production, processing, distribution, and marketing of foods in the United States is overseen by several Federal regulatory agencies, as well as their counterparts in each of the individual states. While somewhat confusing at first glance, the responsibilities of each agency reflects its specific jurisdiction and mission. State agencies provide oversight for food products produced and consumed within that state, whereas Federal regulatory agencies have responsibility for the interstate and international commerce. At the Federal level, responsibilities are divided on the basis of commodity and/or activity lines. The USDA Food Safety and Inspection Service is responsible for the inspection of meat, poultry, and egg products, where as the DHHS Food and Drug Administration has jurisdiction of virtually all other products including fruits, vegetables, shell eggs, and seafood. The FDA also has primary responsibility for the pre-market approval of food additives and the development of the 'Food Code' for retail food operations. The EPA is responsible for the pre-market approval of pesticides and related antimicrobials for use with raw agricultural commodities. While there are differences in how each of these agencies approach their responsibilities, the goal of each is to ensure food manufacturers meet their responsibility for producing safe foods, and that the US consumer has confidence in the safety of the US food supply.
KW - additives
KW - antiinfective agents
KW - eggs
KW - food additives
KW - food products
KW - food safety
KW - food supply
KW - foods
KW - fruits
KW - legislation
KW - marketing
KW - pesticides
KW - poultry
KW - seafoods
KW - vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adjuncts
KW - antimicrobials
KW - domesticated birds
KW - United States of America
KW - vegetable crops
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416394&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Optimization of extraction conditions for active components in Hypericum perforatum using response surface methodology.
AU - Liu, F. F.
AU - Ang, C. Y. W.
AU - Springer, D.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2000///
VL - 48
IS - 8
SP - 3364
EP - 3371
SN - 0021-8561
AD - Liu, F. F.: Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 20000314973. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 67-64-1, 64-17-5. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science
N2 - Optimal conditions for extraction of H. perforatum were determined using response surface methodology. A 3×4×4 full factorial design representing 3 extraction temperatures, 4 extraction times, and 4 solvent concentrations was executed. The overall extraction efficiency was defined by comparing either the total extractable material weight or the individual component peak area to the peak area of luteolin as internal standard. Of the tested variables, the extraction temperature most significantly affected extraction efficiency. Higher temperatures gave better extraction efficiencies, but high temperature also caused decomposition of hypericin. Within the test range, responses for most variables had local maxima. Optimum ranges of time and concentration for individual variables were overlaid. Considering all variables, optimum ranges for extraction time and extraction solvent concentration (percent ethanol in acetone) were 5-6.7 h and 44-74% at 23°C, 5.4-6.9 h and 45-72% at 40°C, and 5.3-5.9 h and 44-69% ethanol in acetone at 55°C.
KW - acetone
KW - analytical methods
KW - chemical composition
KW - ethanol
KW - extraction
KW - medicinal plants
KW - methodology
KW - plant composition
KW - quality
KW - quinones
KW - solvents
KW - temperature
KW - Hypericum perforatum
KW - Hypericum
KW - Clusiaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - 2-propanone
KW - analytical techniques
KW - chemical constituents of plants
KW - dimethyl ketone
KW - drug plants
KW - ethyl alcohol
KW - hypericin
KW - medicinal herbs
KW - methods
KW - officinal plants
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000314973&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Distribution of total 14C residue in egg yolk, albumen, and tissues following oral [14C]sulfamethazine administration to hens.
AU - Badar Shaikh
AU - Chu PakSin
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2000///
VL - 48
IS - 12
SP - 6404
EP - 6408
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Badar Shaikh: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
N1 - Accession Number: 20013004741. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 57-68-1. Subject Subsets: Poultry; Veterinary Science; Veterinary Science
N2 - The distribution of total 14C residues was studied in egg yolk and albumen after administration of either single or multiple oral dosages of [14C]sulfamethazine (SMZ). One day after a single dose of [14C]SMZ (121 mg of sulfamethazine, 2.42×107 dpm), the 14C residue concentration peaked in egg albumen and egg yolk with the concentration in the former >4-fold greater than in the latter. Three days postdose, the 14C residue concentration in the yolk was ~7-fold higher than in the egg albumen. A multiple dose of [14C]SMZ containing sulfamethazine mass equivalent of an average therapeutic dose (282 mg, 2.9×107 dpm) for chickens was also administered orally for six consecutive days to hens. A significantly reduced level of egg production was observed during the medication, and most of the hens stopped laying eggs after the last dose. The 14C residue concentrations peaked on the last day (sixth) of medication in egg albumen and yolk. The 14C residue concentrations were also measured in liver, muscle, blood, and plasma of chickens sacrificed at 1, 24, 48, and 72 h after the last dose. Highest concentrations of 14C residue were accumulated in liver followed by, in decreasing order, blood, plasma, and muscle.
KW - antibacterial agents
KW - blood
KW - drug residues
KW - egg production
KW - eggs
KW - liver
KW - meat
KW - poultry
KW - sulfadimidine
KW - sulfonamides
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - agg albumen
KW - chickens
KW - domesticated birds
KW - sulfamethazine
KW - sulphadimidine
KW - sulphonamides
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Egg Producing Animals (LL130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013004741&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total 14C residues of sarafloxacin in eggs of laying hens.
AU - Chu PakSin
AU - Donoghue, D. J.
AU - Badar Shaikh
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2000///
VL - 48
IS - 12
SP - 6409
EP - 6411
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Chu PakSin: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA.
N1 - Accession Number: 20013004742. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9006-50-2. Subject Subsets: Poultry; Veterinary Science; Veterinary Science
N2 - [14C]Sarafloxacin was orally administered to six laying hens for five consecutive days. Eggs were collected for 15 days after the initial drug treatment. Egg yolk and egg albumen were separated and assayed for total radioactive residues (TRR) using a combustion oxidizer and scintillation counting techniques. Radioactivity was detected in egg yolk and egg albumen on the second day of dosing and reached a maximum at 24 h after drug withdrawal. Thereafter, the sarafloxacin TRR levels in egg albumen declined rapidly and were undetectable 2 days after the last dose, whereas the levels in egg yolk declined at a much slower rate and were undetectable 7 days after drug withdrawal. In both the egg albumen and yolk, HPLC analysis indicated that the parent sarafloxacin was the major component.
KW - drug residues
KW - egg albumen
KW - egg yolk
KW - eggs
KW - poultry
KW - quinolones
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - domesticated birds
KW - egg white
KW - sarafloxacin
KW - yolk
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013004742&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of organochlorine and organophosphorus pesticide residues in eggs using a solid phase extraction cleanup.
AU - Schenck, F. J.
AU - Donoghue, D. J.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2000///
VL - 48
IS - 12
SP - 6412
EP - 6415
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Schenck, F. J.: Southeast Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth Street N.E., Atlanta, Georgia 30309, USA.
N1 - Accession Number: 20013004743. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - A multiresidue solid phase extraction (SPE) method for the isolation and subsequent gas chromatographic determination of non polar organochlorine and polar organophosphorus pesticide residues in eggs is described. The method uses an acetonitrile extraction followed by an SPE cleanup using graphitized carbon black and aminopropyl SPE columns. Organophosphorus pesticides are determined by gas chromatography with flame photometric detection. After further cleanup of the extract using Florisil SPE columns, organochlorine pesticides are determined by gas chromatography with electron capture detection. Studies were performed using eggs containing both fortified and incurred pesticide residues. The average recoveries were 86-108% for 8 fortified organochlorine pesticide residues and 61-149% for 28 fortified organophosphorus pesticide residues.
KW - analytical methods
KW - contamination
KW - eggs
KW - foods
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticides
KW - analytical techniques
KW - organic chlorine pesticides
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013004743&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Imaging residue transfer into egg yolks.
AU - Donoghue, D. J.
AU - Myers, K.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2000///
VL - 48
IS - 12
SP - 6428
EP - 6430
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Donoghue, D. J.: Division of Animal Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA.
N1 - Accession Number: 20013004746. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Poultry; Veterinary Science; Veterinary Science
N2 - Prediction models for residue transfer into eggs are being developed. Recent results indicate that the developing egg yolk serves as an important storage depot for chemical residues. The current study was conducted to visualize incorporation and potential compartmentalization of drug residues in developing egg yolks. To this end, the drug magnevist was injected into hens to evaluate drug transfer into either early- or late-developing yolks. High-resolution magnetic resonance images (MRI) of drug residues in eggs were acquired using a 1.5 T Siemens Magnetom clinical scanner. A 10-cm circular surface coil was used for receiving the magnetic resonance signal. The eggs were positioned inside the coil cavity for an improved signal to noise ratio (SNR). Gradient-echo images were used to locate the centers of the eggs and to prescribe the position of the high-resolution image slab. The images were recorded using an inversion time (T1) weighted magnetization-prepared, rapid acquisition, gradient-recalled-echo (MPRAGE) pulse sequence. The sequence parameters used were as follows: repetition time (TR) equals 12 ms, echo time (TE) equals 5 ms, field of view (FOV) equals 200, TI=10 ms, 1.25-mm slice thickness, and a matrix of 200×256. Following dosing, images of drug residues in eggs indicate that drugs can be incorporated and compartmentalized into ring structures within individual developing egg yolks. These results have significant human food safety implications because even after only a single dose, sequestered drug residues may be stored and later released to contaminate eggs for days to weeks after dosing.
KW - antibiotics
KW - assays
KW - drug residues
KW - eggs
KW - image analysis
KW - poultry
KW - techniques
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - domesticated birds
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation by protein kinase of phagocytosis of Mycobacterium leprae by macrophages.
AU - Prabhakaran, K.
AU - Harris, E. B.
AU - Randhawa, B.
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
Y1 - 2000///
VL - 49
IS - 4
SP - 339
EP - 342
SN - 0022-2615
AD - Prabhakaran, K.: US Public Health Service, GWL Hansen's Disease Center @ Louisiana State University, PO Box 25072, Baton Rouge, LA 70894-5072, USA.
N1 - Accession Number: 20002011487. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 446-72-0, 9026-43-1. Subject Subsets: Tropical Diseases
N2 - M. leprae multiplies within host macrophages, although the mechanism of internalization of the bacteria by the phagocytic cells is unknown. In this study, M. leprae was purified from the foot pads of experimentally infected nu/nu mice. Peritoneal macrophages were harvested from BALB/c mice or C57 beige (bg/bg) mice. The effect of protein kinase inhibitors (erbstatin, genistein or staurosporine for BALB/c and bg/bg mice, plus herbimycin for bg/bg mice) on phagocytosis of the mycobacteria by the macrophage monolayers was tested. The untreated (control) macrophages phagocytosed M. leprae. Phagocytosis by BALB/c macrophages was inhibited by erbstatin and staurosporine but not by genistein; all the protein kinase inhibitors prevented uptake of M. leprae by bg/bg cells. The results demonstrate that protein kinase regulates phagocytosis of M. leprae by macrophages. It is concluded that the mechanism might prove to be a rational drug target for mycobacteria that multiply intracellularly.
KW - enzyme activity
KW - enzyme inhibitors
KW - genistein
KW - human diseases
KW - macrophages
KW - pathogenesis
KW - phagocytosis
KW - protein kinase
KW - man
KW - mice
KW - Mycobacterium
KW - Mycobacterium leprae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterium
KW - biochanin A
KW - erbstatin
KW - staurosporine
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycobacterium septicum sp. nov., a new rapidly growing species associated with catheter-related bacteraemia.
AU - Schinsky, M. F.
AU - McNeil, M. M.
AU - Whitney, A. M.
AU - Steigerwalt, A. G.
AU - Lasker, B. A.
AU - Floyd, M. M.
AU - Hogg, G. G.
AU - Brenner, D. J.
AU - Brown, J. M.
JO - International Journal of Systematic and Evolutionary Microbiology
JF - International Journal of Systematic and Evolutionary Microbiology
Y1 - 2000///
VL - 50
IS - 2
SP - 575
EP - 581
AD - Schinsky, M. F.: Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases and Tuberculosis/Mycobacteriology Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20002012183. Publication Type: Journal Article. Language: English. Number of References: 25 ref.
N2 - A previously unidentified, rapidly growing mycobacterium was determined to be the causative agent of central line sepsis in a child with underlying metastatic hepatoblastoma. Four isolates of this mycobacterium, 3 from blood and 1 from the central venous catheter tip, were studied. Phenotypic characterization, HPLC and genetic analysis revealed that while this organism most closely resembled members of the Mycobacterium fortuitum complex and Mycobacterium senegalense, it differed from all previously described species. Phenotypic tests useful in differentiating this species from similar rapidly growing mycobacteria included: growth at 42°C, hydrolysis of acetamide, utilization of citrate, production of arylsulfatase (3-d), acidification of D-mannitol and i-myo-inositol, and susceptibility to erythromycin, vancomycin and tobramycin. The name Mycobacterium septicum is proposed for this new species. The type strain was deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen as DSM 44393T and in the American Type Culture Collection as strain ATCC 700731T.
KW - bacteraemia
KW - catheters
KW - children
KW - classification
KW - HPLC
KW - human diseases
KW - identification
KW - isolation
KW - mycobacterial diseases
KW - new species
KW - phenotypes
KW - sepsis
KW - taxonomy
KW - Clostridium septicum
KW - man
KW - Mycobacterium
KW - Mycobacterium fortuitum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Mycobacterium
KW - bacteremia
KW - bacterium
KW - high performance liquid chromatography
KW - mycobacterial infections
KW - systematics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutritional and hematological impact of dietary flaxseed and defatted flaxseed meal in rats.
AU - Babu, U. S.
AU - Mitchell, G. V.
AU - Wiesenfeld, P.
AU - Jenkins, M. Y.
AU - Hemavathi Gowda
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
Y1 - 2000///
VL - 51
IS - 2
SP - 109
EP - 117
SN - 0963-7486
AD - Babu, U. S.: Division of Science and Applied Technology, Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel MD 20708, USA.
N1 - Accession Number: 20001412549. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 9001-78-9, 57-88-5, 7439-89-6, 1406-18-4, 7440-66-6. Subject Subsets: Human Nutrition
N2 - An 8-week study was conducted to determine the impact of dietary ground flaxseed (FS) or defatted flaxseed meal (FLM) on plasma lipids, minerals, haematological parameters and vitamin E status of weanling female Sprague-Dawley rats. These rats were fed isocaloric modified AIN-76 diets supplemented with 0.0, 5.0, 10.0% (w/w) FS or 6.2% (w/w) FLM for 56 days. Total and HDL cholesterol were not influenced by any of the dietary treatments. Plasma triglyceride was significantly increased by FLM, but not affected by FS. Total RBC counts and haematocrit were significantly higher in FS groups than in the control group; however, haemoglobin was not affected by FS. Dietary FLM had no effect on any of the above haematological parameters. Plasma alkaline phosphatase, an indicator of Zn status and a marker of bone formation, was significantly lower in the FS and FLM groups than in the control group. Plasma vitamin E content was not influenced by dietary treatment. Liver vitamin E was significantly higher in groups fed 10% FS and 6.2% FLM. It is concluded that moderate amounts of dietary FS may have the potential to increase liver vitamin E level and improve iron status. However, FS/FLM consumption may have a negative effect on zinc status, as indicated by decreased alkaline phosphatase levels.
KW - alkaline phosphatase
KW - blood chemistry
KW - bone formation
KW - cholesterol
KW - diets
KW - flax
KW - haemoglobin
KW - iron
KW - linseed
KW - lipids
KW - liver
KW - minerals
KW - rat feeding
KW - seeds
KW - supplements
KW - triacylglycerols
KW - vitamin E
KW - zinc
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - alkaline phosphomonoesterase
KW - bone calcification
KW - flaxseeds
KW - hemoglobin
KW - lipins
KW - triglycerides
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Nutrition (Physiology) (LL510)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001412549&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury.
AU - Hong JinTae
AU - Ryu SeungRel
AU - Kim HyeJin
AU - Lee JongKwon
AU - Lee SunHee
AU - Kim DaiByung
AU - Yun YeoPyo
AU - Ryu JongHoon
AU - Lee ByungMu
AU - Kim PuYoung
JO - Brain Research Bulletin
JF - Brain Research Bulletin
Y1 - 2000///
VL - 53
IS - 6
SP - 743
EP - 749
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0361-9230
AD - Hong JinTae: National Institute of Toxicological Research, Korea Food and Drug Administration, 5, Nokbun-dong, Eunpyung-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20013032567. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7782-44-7, 11000-26-3.
N2 - Eicosanoids accumulation and formation of oxygen free radicals have been implicated in the pathogenesis of ischaemia/reperfusion brain injury. In the present study, we examined whether green tea extract protects against ischaemia/reperfusion-induced brain injury by minimizing eicosanoid accumulation and oxygen radical-induced oxidative damage in the brain. Green tea extract (0.5%) was orally administered to Wistar rats for 3 weeks before induction of ischaemia. Ischaemia was induced by the occlusion of middle cerebral arteries for 60 min and reperfusion was achieved for 24 h. Infarction volume in the ipsilateral hemisphere of ischaemia/reperfusion animals was 114±16 mm3 in the 0.5% green tea pretreated animals compared to 180±54 mm3 in left hemisphere of nontreated animals. Green tea extract (0.5%) also reduced ischaemia/reperfusion-induced eicosanoid concentration: Leukotriene C4 (from 245±51 to 186±22), prostaglandin E2 (from 306±71 to 212±43) and thromboxane A2 (327±69 to 251±87 ng/mg protein). Ischaemia/reperfusion-induced increases of hydrogen peroxide level (from 688±76 to 501±99 nmole/mg protein), lipid peroxidation products (from 1010±110 to 820±70 nmole/mg protein) and 8-oxodG formation (from 1.3±0.3 to 0.8±0.2 ng/µg DNA, × 10-2) were also reduced. Moreover, 0.5% green tea extract also reduced the apoptotic cell number (from 44±11 to 29±1 in the striatum, and from 72±11 to 42±5 apoptotic cells/high power field in the cortex region). Green tea extract pretreatment also promoted recovery from the ischaemia/reperfusion-induced inhibition of active avoidance. The present study shows that the minimizing effect of green tea extract on the eicosanoid accumulation and oxidative damage in addition to the reduction of neuronal cell death could eventually result in protective effect on the ischaemia/reperfusion-induced brain injury and behaviour deficit.
KW - brain
KW - eicosanoids
KW - free radicals
KW - green tea
KW - infarction
KW - ischaemia
KW - leukotrienes
KW - oxygen
KW - prostaglandins
KW - tea
KW - thromboxanes
KW - trauma
KW - Camellia sinensis
KW - rats
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cerebrum
KW - ischemia
KW - traumas
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mu-class GSTs are responsible for aflatoxin B1-8,9-epoxide-conjugating activity in the nonhuman primate Macaca fascicularis liver.
AU - Wang, C.
AU - Bammler, T. K.
AU - Guo YingYing
AU - Kelly, E. J.
AU - Eaton, D. L.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000///
VL - 56
IS - 1
SP - 26
EP - 36
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Wang, C.: National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Dr., HFT-100, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013082248. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 50812-37-8. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition
N2 - Mice are resistant to the carcinogenic effects of the mycotoxin aflatoxin B1 (AFB1) because they constitutively express an alpha-class glutathione S-transferase (mGSTA3-3) that has high (~200,000 pmol/min/mg) activity toward aflatoxin B1-8,9-epoxide (AFBO). Rats do not constitutively express a GST with high AFBO-conjugating activity and are sensitive to AFB1-induced hepatocarcinogenesis. Constitutively expressed human hepatic alpha-class GSTs (hGSTA1-1 and hGSTA2-2) possess little or no AFBO-detoxifying activity (<2 pmol/min/mg). Recently, we found that the nonhuman primate, Macaca fascicularis (Mf), exhibits significant (~300 pmol/min/mg) constitutive hepatic GST activity towards AFBO. To determine which specific GST isoenzyme(s) is (are) responsible for this activity, Mf GSTs were purified from liver tissue and characterized, and Mf mu-class GST cDNAs were cloned by reverse transcriptase-coupled polymerase chain reaction (RT-PCR). Purification by glutathione agarose (GSHA) affinity chromatography yielded a protein, GSHA-GST, that exhibited relatively high AFBO-conjugating activity (239 pmol/min/mg) compared to other GST-containing peaks. Western blotting and enzymatic activity analyses revealed that GSHA-GST belongs to the mu class. Two distinct mu-class GST cDNAs, mfaGSTM1 (GenBank accession # AF200709) and mfaGSTM2 (GenBank accession # AF200710), were generated by RT-PCR. CDNA-derived amino acid sequence analysis revealed that mfaGSTM1 and mfaGSTM2 share 97% and 96% homology with the human mu-class GSTs hGSTM4 and hGSTM2, respectively. In contrast to recombinant mfaGSTM1-1, which had no detectable AFBO-conjugating activity, mfaGSTM2-2 exhibited this activity at 333 pmol/min/mg. Activity profiles for the stereoisomers exo- and endo-AFBO, and of 1-chloro-2,4-dinitrobenzene of the purified protein GSHA-GST and recombinant mfaGSTM2-2, suggested that they are two distinct enzymes. Our results indicate that, in contrast to rodents, mu-class GSTs are responsible for the majority of AFBO-conjugating activity in the liver of Macaca fascicularis.
KW - aflatoxins
KW - detoxification
KW - enzyme activity
KW - enzymes
KW - epoxides
KW - glutathione transferase
KW - isoenzymes
KW - liver
KW - mycotoxins
KW - toxicity
KW - Macaca fascicularis
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - isozymes
KW - ligandin
KW - Toxinology (VV820) (New March 2000)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbial risk assessment: dose-response relations and risk characterization.
AU - Buchanan, R. L.
AU - Smith, J. L.
AU - Long, W.
A2 - Gorris, L. G. M.
A2 - Jouve, J. L.
A2 - Stringer, M. L.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2000///
VL - 58
IS - 3
SP - 159
EP - 172
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Buchanan, R. L.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C-Street, SW Washington, DC 20204, USA.
N1 - Accession Number: 20013095590. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 26 ref.
N2 - The 4 cornerstones of microbial food safety risk assessment are hazard identification, exposure assessment, hazard characterization, and risk characterization. These steps represent a systematic process for identifying adverse consequences and their associated probabilities arising from consumption of foods that may be contaminated with microbial pathogens and/or microbial toxins. This paper presents a discussion of the last 2 steps: dose response assessment (hazard characterization) and risk characterization. This include an in depth consideration of dose-response modelling and a general consideration of potential pitfalls associated with risk characterization. Principles and techniques related to quantitative microbial food safety risk assessments are discussed.
KW - food contamination
KW - food safety
KW - health hazards
KW - microbial contamination
KW - risk
KW - risk assessment
KW - food contaminants
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bactericidal action of ampicillin/sulbactam against intracellular mycobacteria in vitro and in vivo.
AU - Prabhakaran, K.
AU - Harris, E. B.
AU - Randhawa, B.
JO - Star, Radiating the Light of Truth on Hansen's Disease
JF - Star, Radiating the Light of Truth on Hansen's Disease
Y1 - 2000///
VL - 59
IS - 2
SP - 2
EP - 4
SN - 0049-2116
AD - Prabhakaran, K.: US Public Health Service, GWL HD Center, LSU, USA.
N1 - Accession Number: 20002016365. Publication Type: Journal Article. Language: English. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 68373-14-8.
KW - ampicillin
KW - antibiotics
KW - antimicrobial properties
KW - drug resistance
KW - human diseases
KW - sulbactam
KW - man
KW - mice
KW - Mycobacterium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - anti-microbial properties
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - 1999 USPHS/IDSA Guidelines for the Prevention of Opportunistic Infections in Persons infected with HIV: Part III. Prevention of disease recurrence.
JO - American Family Physician
JF - American Family Physician
Y1 - 2000///
VL - 61
IS - 3
SP - 771
EP - 778, 780, 785
CY - Leawood; USA
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
N1 - Accession Number: 20013091074. Publication Type: Journal Article. Corporate Author: USA, U. S. Department of Health and Human Services Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology; Medical & Veterinary Mycology; Protozoology; Tropical Diseases
N2 - This third part of the "Guidelines for the Prevention of Opportunistic Infections in Persons with Human Immunodeficiency Virus" gives recommendations for the prevention of recurrence of opportunistic diseases (Pneumocystis carinii pneumonia, toxoplasmic encephalitis, cryptosporidiosis, microsporidiosis, tuberculosis, disseminated infection with Mycobacterium avium complex, bacterial respiratory infections, bacterial enteric infections, Bartonella infection, candidosis, cryptococcosis, histoplasmosis, coccidioidomycosis, cytomegalovirus disease, herpes simplex virus disease, varicella-zoster virus infection, human herpesvirus 8 infection, human papillomavirus infection and hepatitis C virus infection), after chemotherapy for acute disease. Tables give dosages for prophylaxis in adults, adolescents and children.
KW - bacterial diseases
KW - candidosis
KW - chemoprophylaxis
KW - children
KW - coccidioidomycosis
KW - cryptococcosis
KW - cryptosporidiosis
KW - disease prevention
KW - encephalitis
KW - guidelines
KW - hepatitis C
KW - herpes simplex viruses
KW - histoplasmosis
KW - HIV infections
KW - human diseases
KW - human herpesviruses
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - intestinal diseases
KW - microsporidiosis
KW - opportunistic infections
KW - Pneumocystis carinii pneumonia
KW - relapse
KW - respiratory diseases
KW - tuberculosis
KW - varicella
KW - viral diseases
KW - Bartonella
KW - Candida
KW - Coccidioides immitis
KW - Cryptococcus (Fungi)
KW - Cryptosporidium
KW - hepatitis C virus
KW - Histoplasma
KW - Human herpesvirus 3
KW - Human herpesvirus 5
KW - human herpesvirus 8
KW - human papillomaviruses
KW - man
KW - Mycobacterium avium
KW - Mycobacterium tuberculosis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - Toxoplasma gondii
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Coccidioides
KW - Onygenaceae
KW - Onygenales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Cryptococcus (Fungi)
KW - Tremellaceae
KW - Tremellales
KW - Tremellomycetes
KW - Agaricomycotina
KW - Basidiomycota
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Ajellomycetaceae
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - Cytomegalovirus
KW - Betaherpesvirinae
KW - Rhadinovirus
KW - Gammaherpesvirinae
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Papillomavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Toxoplasma
KW - Sarcocystidae
KW - Papillomaviridae
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - candidiasis
KW - chicken pox
KW - coccidiomycosis
KW - Cryptococcus (Deuteromycotina)
KW - encephalomyelitis
KW - enteropathy
KW - european blastomycosis
KW - fungus
KW - herpes simplex virus
KW - human cytomegalovirus
KW - Human herpesvirus
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human papillomavirus
KW - Hyphomycetes
KW - lung diseases
KW - Papovaviridae
KW - recommendations
KW - recurrence of disease
KW - relapses
KW - varicella-zoster virus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a versatile method for the detection of nicotine in air.
AU - Pendergrass, S. M.
AU - Krake, A. M.
AU - Jaycox, L. B.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 2000///
VL - 61
IS - 4
SP - 469
EP - 472
SN - 0002-8894
AD - Pendergrass, S. M.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20002017178. Publication Type: Journal Article. Language: English. Number of References: 9 ref.
N2 - The development of an improved sampling and analytical methodology for nicotine was required to accommodate the broad concentration of nicotine levels and varying sampling scenarios presented by differing health hazard evaluation (HHE) requests. A XAD-4 sorbent tube was selected for the collection of airborne nicotine. Analytical methodology for the separation, identification and quantitation of nicotine by both gas chromatography-flame ionization detection and gas chromatography-nitrogen/phosphorous detection is described. The limit of detection for nicotine was 0.013 µg/sample. The desorption efficiency for nicotine was determined over the range of study and ranged from 90.9% (0.096 µg) to 93.7% (24.0 µg). Nicotine exhibited storage stability for 30 days at 5°C and for 14 days at ambient temperature.
KW - air
KW - analytical methods
KW - contamination
KW - environment
KW - estimation
KW - health
KW - health hazards
KW - inhalation
KW - methodology
KW - quantitative techniques
KW - techniques
KW - tobacco
KW - workers
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - analytical techniques
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells.
AU - Hong JinTae
AU - Park KuiLea
AU - Han SoonYoung
AU - Park KiSook
AU - Kim HyungSik
AU - Oh SeDong
AU - Lee RheeDa
AU - Jang SeungJae
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2000///
VL - 61
IS - 7
SP - 609
EP - 621
CY - London; UK
PB - Taylor & Francis Ltd
SN - 1528-7394
AD - Hong JinTae: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20003033090. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - In the present study, the effects of ochratoxin A (OTA) on cytotoxicity, cell differentiation, and other cell functions in the embryonic midbrain cells, which are dopaminergic, were compared to those in the limb bud cells, which are nondopaminergic, to assess the selectivity of OTA central action. 12-day rat embryo midbrain and limb bud cells were cultured in Dulbecco's modified Eagle's medium nutrient and Ham's F12 (1:1) mixture containing 10% Nuserum for 96 h in the presence of various concentrations of OTA. OTA significantly reduced the levels of protein, DNA and glutathione, and [3H]thymidine incorporation into DNA in both embryonic midbrain and limb bud cells in a similar concentration-dependent manner. The IC50 values for cytotoxicity measured by neutral red uptake were 1.10 µM in the midbrain cells and 1.05 µM in the limb bud cells. The IC50 values of cell differentiation were 1.10 µM in the midbrain cells and 1.0 µM in the limb bud cells. The addition of exogenous glutathione (32.5 µM) did not change the OTA-induced fall in protein and DNA levels, or the IC50 values of cytotoxicity and differentiation in the midbrain and limb bud cells. Data show that OTA does not appear to exert a selective toxic dopaminergic cell action and that OTA-induced cytotoxicity and inhibition of cell differentiation were not prevented by exogenous glutathione.
KW - cytotoxicity
KW - embryos
KW - mycotoxins
KW - ochratoxins
KW - teratogenesis
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - Toxinology (VV820) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk assessment used to evaluate the US position on Listeria monocytogenes in seafood.
AU - Elliot, E. L.
AU - Kvenberg, J. E.
T3 - Special issue: FAO expert consultation on the trade impact of Listeria in fish products
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2000///
VL - 62
IS - 3
SP - 253
EP - 260
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Elliot, E. L.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-615, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013080127. Publication Type: Journal Article. Note: Special issue: FAO expert consultation on the trade impact of Listeria in fish products Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Human listeriosis has been associated with consumption of food including seafood. Surveillance information on the presence of Listeria monocytogenes in seafood products is presented as a background for steps that are being taken to inform risk managers of risks associated with particular food products. USA policy for L. monocytogenes in food has been shaped by our increasing knowledge of the epidemiology of outbreaks and sporadic cases of human listeriosis, the potentially severe public health consequences, and the characteristics of the organism. A quantitative risk assessment of the scientific knowledge we have about the organism and the epidemiology of listeriosis should be the basis for changes in this policy. Risk assessment uses quantitative scientific and epidemiological information in a structured format to determine the risks associated with particular hazards. A quantitative risk assessment is being performed using currently available data by the US Food and Drug Administration, in collaboration with the US Food Safety and Inspection Service, to determine the risk of listeriosis from various foods, including seafood, for specific intervention methods, and for general and at-risk population groups. The questions being considered include those on level of consumption, epidemiology, dose response, and the virulence, biology, and ecology of the organism. Risk managers can use the resulting information to form a defendable science-based policy on L. monocytogenes in food.
KW - food contamination
KW - food safety
KW - foods
KW - human diseases
KW - listeriosis
KW - microbial contamination
KW - quantitative analysis
KW - risk
KW - risk assessment
KW - seafoods
KW - USA
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - listerellosis
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy of vaccines containing rhoptry-associated proteins RAP1 and RAP2 of Plasmodium falciparum in Saimiri boliviensis monkeys.
AU - Collins, W. E.
AU - Walduck, A.
AU - Sullivan, J. S.
AU - Andrews, K.
AU - Stowers, A.
AU - Morris, C. L.
AU - Jennings, V.
AU - Yang ChunFu
AU - Kendall, J.
AU - Lin QingHui
AU - Martin, L. B.
AU - Diggs, C.
AU - Saul, A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2000///
VL - 62
IS - 4
SP - 466
EP - 479
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Scientific Resources Branch, Division of Parasitic Diseases, Public Health Service, United States Department of Health and Human Services, National Center for Infectious Disease, Centers for Disease Control and Prevention, Mailstop F-12, 4770 Buford Highway, Chamblee, Atlanta, GA 30341, USA.
N1 - Accession Number: 20013024944. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology
N2 - A vaccine trial was conducted with rhoptry-associated proteins 1 and 2 (RAP1 and RAP2) of Plasmodium falciparum in Saimiri boliviensis monkeys to compare the ability of parasite-derived (PfRAP1 and 2) and recombinant proteins (rRAP1 and 2) to induce protective immune responses and to find adjuvants suitable for use in humans. Eight groups of 6 monkeys each were immunized with parasite-derived or recombinant RAP1 and 2 with Freund's complete adjuvant (FCA) followed by Freund's incomplete adjuvant (FIA), Montanide ISA720 adjuvant, or CRL1005 adjuvant. Recombinant RAP1 and RAP2 were also administered separately, with Montanide ISA720. After 3 immunizations, monkeys were challenged by iv inoculation of 50 000 parasites of the Uganda Palo Alto strain of P. falciparum. Of the animals vaccinated using FCA/FIA, 1 of 6 control monkeys, 3 of 6 immunized with PfRAP1 and 2, and 2 of 6 with rRAP1 and 2 did not require drug treatment. Of the monkeys vaccinated with Montanide ISA720 adjuvant, 0 of the 6 control monkeys, 2 of 6 immunized with RAP1 and 2, 1 of 6 immunized with rRAP1, and 4 of 6 immunized with RAP2 did not require drug treatment. Two of 6 monkeys immunized with PfRAP1 and 2 with CRL1005 did not require treatment. All groups receiving RAP1, RAP2, or both had a significant decrease in initial parasite multiplication rates and there was a significant negative correlation between anti-RAP2 antibody and multiplication rates. Animals were rechallenged with the homologous parasite 126 days after the first challenge. Of the monkeys that did not require drug treatment after the first challenge, none developed detectable parasitaemia following rechallenge.
KW - experimental infections
KW - immunization
KW - laboratory animals
KW - proteins
KW - protozoal infections
KW - vaccination
KW - vaccine development
KW - vaccines
KW - Plasmodium falciparum
KW - Saimiri boliviensis
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Saimiri
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - immune sensitization
KW - protozoal diseases
KW - Host Resistance and Immunity (HH600)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence and characterization of Listeria monocytogenes from domestic and imported foods in Korea.
AU - Baek SunYoung
AU - Lim SoonYoung
AU - Lee DongHa
AU - Min KyungHee
AU - Kim ChangMin
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 2
SP - 186
EP - 189
SN - 0362-028X
AD - Baek SunYoung: Division of Food Microbiology, Korea Food and Drug Administration, 5 Nokbon-Dong, Eunpyung-Ku, Seoul 122-020, Korea Republic.
N1 - Accession Number: 20000403485. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science; Human Nutrition
N2 - 1537 samples of domestic and imported food products were examined for the incidence of L. monocytogenes between 1993 and 1997 in Korea. L. monocytogenes was detected using the USDA isolation method. Isolated L. monocytogenes was confirmed by polymerase chain reaction with hly1 and hly2 primers designed from the listeriolysin O. Overall, 122 samples (7.9%) contained L. monocytogenes. The rate of isolation was 4.3% for beef, 19.1% for pork, 30.2% for chicken, 1.2% for shellfish, 4.4% for raw milk, 4.4% for frozen smoked mussels, and 6.1% for ice cream. No L. monocytogenes was found in pasteurized milk, pasteurized processed cheese, saltwater fish, dried seafoods or ham. The overall incidence was lower than that reported in previous studies from other countries. Most isolates were serotype 1/2b except for chicken, in which serotype 1/2a was predominant. It is concluded that the serotyping results might imply the presence of food or geography-specific L. monocytogenes strains.
KW - bacterial diseases
KW - characterization
KW - cheeses
KW - food contamination
KW - food hygiene
KW - foods
KW - ice cream
KW - incidence
KW - meat
KW - meat products
KW - microbial contamination
KW - milk products
KW - mussels
KW - pasteurized milk
KW - polymerase chain reaction
KW - processed cheese
KW - raw milk
KW - seafoods
KW - Korea Republic
KW - Listeria monocytogenes
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - dairy products
KW - food contaminants
KW - PCR
KW - South Korea
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of thermophilic Campylobacter spp. in blood-free enriched samples of inoculated foods by the polymerase chain reaction.
AU - Thunberg, R. L.
AU - Tran, T. T.
AU - Walderhaug, M. O.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 3
SP - 299
EP - 303
SN - 0362-028X
AD - Thunberg, R. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street SW, Washington, D.C. 20204, USA.
N1 - Accession Number: 20000403889. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - The detection of thermophilic Campylobacter spp., as represented by Campylobacter jejuni, by the polymerase chain reaction (PCR) was investigated and compared with the selective agar isolation (SAI) method. Stationary-phase cultures of C. jejuni were inoculated into blood-free enrichment broth (BFEB) or BFEB that contained 10% broccoli, crab meat, mushroom, raw milk and raw oyster rinses. Following a 48-h enrichment period, aliquots of food test portions were removed for simultaneous analysis by PCR and SAI. The presence of charcoal and iron in the enrichment broth interfered with the PCR assay. Therefore, 3 DNA extraction techniques were developed and evaluated using a 16S rRNA primer pair in the PCR assay. The 50% end point (DL50) values (determined upon 6 initial C. jejuni spiking levels) were used to assess the frequency of isolation utilizing PCR vs. SAI for the detection of this organism in the enrichment matrices. There were virtually no differences in detection of C. jejuni among enriched samples analysed by PCR and SAI. Mean DL50 values (n = 3) for plain BFEB, broccoli, crab meat, mushroom, raw milk and raw oyster were, respectively, 0.02 (PCR) vs. 0.01 (SAI), 0.01 vs. 0.06, 0.07 vs. 0.04, 0.03 vs. 0.08, 0.01 vs. 0.01, and 0.01 vs. 0.01 c.f.u./5 g food. Significant variability in the detection limit of C. jejuni by PCR in the food enrichments was observed among DNA extraction techniques. It is concluded that using 48-h enrichment cultures followed by PCR analysis decreases the time required for the presumptive identification of C. jejuni in suspected foods by a day.
KW - analytical methods
KW - broccoli
KW - crab meat
KW - cultures
KW - detection
KW - edible fungi
KW - enrichment
KW - foods
KW - microbial contamination
KW - mushrooms
KW - oysters
KW - polymerase chain reaction
KW - raw milk
KW - vegetables
KW - Brassica oleracea
KW - Campylobacter jejuni
KW - fungi
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - calabrese
KW - Capparales
KW - PCR
KW - vegetable crops
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Meat Produce (QQ030)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence of Salmonella in fish and seafood.
AU - Heinitz, M. L.
AU - Ruble, R. D.
AU - Wagner, D. E.
AU - Tatini, S. R.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 5
SP - 579
EP - 592
SN - 0362-028X
AD - Heinitz, M. L.: U.S. Food and Drug Administration, 240 Hennepin Avenue, Minneapolis, Minnesota 55401-1999, USA.
N1 - Accession Number: 20001416557. Publication Type: Journal Article. Language: English. Number of References: 101 ref. Subject Subsets: Human Nutrition
N2 - Field laboratories of the US Food and Drug Administration collected and tested 11 312 import and 768 domestic seafood samples over a 9-year period (1990 to 1998) for the presence of Salmonella. The overall incidence of Salmonella was 7.2% for import and 1.3% for domestic seafood. Nearly 10% of import and 2.8% of domestic raw seafood were positive for Salmonella. The overall incidence of Salmonella in ready-to-eat seafood and shellfish eaten raw was 0.47% for domestic - one shucked oyster and one shark cartilage powder. The incidence in the 2,734 ready-to-eat import seafood was 2.6% - cooked shrimp, shellfish or fish paste, smoked fish, salted/dried fish, and caviar. The incidence in import shellfish consumed raw was 1% in oyster, 3.4% in clams, and 0% in mussels. The incidence in raw, import fish was 12.2%. Distribution of Salmonella in seafood on a regional basis indicated the incidence to be highest in central Pacific and Africa and lowest in Europe/Russia and North America (12 vs. 1.6%). Data on a country basis indicated Vietnam to have the highest (30%) and Republic of Korea the lowest (0.7%). While the most frequent serotypes in import seafood were Salmonella Weltevreden (1st), Salmonella Senftenberg (2nd), Salmonella Lexington, and Salmonella Paratyphi-B (3rd, equal numbers for each serotype), the top 20 list included Salmonella Enteritidis (5th), Salmonella Newport (6th), Salmonella Thompson (7th), Salmonella Typhimurium (12th), and Salmonella Anatum (13th), commonly involved in foodborne illness in the United States. Because the incidence in the present study is based on only a small fraction of the seafood imported into the United States, efforts should be directed toward implementation of hazard analysis and critical control points to reduce the incidence of Salmonella in seafood without relying on testing for Salmonella.
KW - contamination
KW - fish
KW - food contamination
KW - foodborne diseases
KW - laboratories
KW - microbial contamination
KW - mussels
KW - seafoods
KW - shellfish
KW - smoked fish
KW - Africa
KW - America
KW - North America
KW - USA
KW - Vietnam
KW - Salmonella
KW - Salmonella enteritidis
KW - Salmonella typhimurium
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - America
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - ASEAN Countries
KW - Developing Countries
KW - Indochina
KW - South East Asia
KW - Asia
KW - bacterium
KW - food contaminants
KW - United States of America
KW - Viet Nam
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001416557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acquisition of microbiological data to enhance food safety.
AU - Buchanan, R. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 6
SP - 832
EP - 838
SN - 0362-028X
AD - Buchanan, R. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street S. W., Washington, D.C. 20204, USA.
N1 - Accession Number: 20002013571. Publication Type: Journal Article. Language: English. Number of References: 4 ref.
N2 - The routine acquisition and archiving of microbiological data is undertaken for two reasons. The first is the development of historical microbiological profiles of foods, ingredients, or processes in order to determine or verify that microorganisms of concern are being controlled to the level desired. The second reason is data concerning the pathogenicity or virulence of foodborne pathogens and their behaviour in foods in order to develop strategies and criteria for assuring microbiological safety. Both types of microbiological data are essential to effective food safety programmes. A firm understanding of the uses and limitations of both is essential to correct acquisition, interpretation, and use of such data.
KW - disease control
KW - epidemiology
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - foods
KW - human diseases
KW - information
KW - pathogenicity
KW - virulence
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation of Salmonella spp. from the housefly, Musca domestica L., and the dump fly, Hydrotaea aenescens (Wiedemann) (Diptera: Muscidae), at caged-layer houses.
AU - Olsen, A. R.
AU - Hammack, T. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 7
SP - 958
EP - 960
SN - 0362-028X
AD - Olsen, A. R.: U.S. Food and Drug Administration, HFS-315, 200 C Street S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 20000507903. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Poultry; Veterinary Science
N2 - Flies, especially houseflies, are widely recognized as potential reservoirs and vectors of foodborne Salmonella pathogens. In this study, flies were collected at 2 different caged-layer facilities that had produced eggs that were implicated as the food vehicle in 2 recent outbreaks of S. enteritidis infections. The flies were separated by species into pools for microbiological testing. A total of 15 species pools of houseflies, M. domestica L., and 7 species pools of bronze dump flies, H. aenescens (Wiedemann) (Diptera: Muscidae), were analysed. S. enteritidis was isolated from 2 of the 15 pools of houseflies. Other species of Salmonella were isolated from 3 pools of flies, including S. infantis from houseflies and from dump flies and S. heidelberg from houseflies. S. mbandaka was isolated from a lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae).
KW - eggs
KW - food contamination
KW - foodborne diseases
KW - hens
KW - isolation
KW - poultry
KW - poultry housing
KW - Alphitobius diaperinus
KW - fowls
KW - Hydrotaea aenescens
KW - Musca domestica
KW - Salmonella enteritidis
KW - Alphitobius
KW - Tenebrionidae
KW - Coleoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Hydrotaea
KW - Muscidae
KW - Diptera
KW - Musca
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - house fly
KW - Salmonella heidelberg
KW - Salmonella infantis
KW - Salmonella mbandaka
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Eggs and Egg Products (QQ040)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differentiation between types and strains of Clostridium botulinum by riboprinting.
AU - Skinner, G. E.
AU - Gendel, S. M.
AU - Fingerhut, G. A.
AU - Solomon, H. A.
AU - Ulaszek, J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 10
SP - 1347
EP - 1352
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Skinner, G. E.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 20003015569. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Agricultural Biotechnology; Veterinary Science
KW - DNA fingerprinting
KW - food
KW - foodborne diseases
KW - ribotyping
KW - Clostridium botulinum
KW - man
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Asitrocin, (2,4)-cis- and trans-asitrocinones: novel bioactive mono-tetrahydrofuran acetogenins from Asimina triloba seeds.
AU - Kim EunJung
AU - Tian FeiFei
AU - Woo MiHee
JO - Journal of Natural Products
JF - Journal of Natural Products
Y1 - 2000///
VL - 63
IS - 11
SP - 1503
EP - 1506
CY - Washington; USA
PB - American Chemical Society
SN - 0163-3864
AD - Kim EunJung: Division of Antibiotics, Department of Drug Evaluation, Korea Food and Drug Administration, Seoul 122-020, Korea Republic.
N1 - Accession Number: 20003036396. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Forest Products; Seed Science; Aromatic & Medicinal Plants; Forestry; Horticultural Science
N2 - Asitrocin (1) and the mixture of (2,4)-cis- and trans-asitrocinones (2 and 3), new bioactive Annonaceous acetogenins, were isolated from the seeds of A. triloba by activity-directed fractionation using the brine shrimp lethality test. Asitrocin and the mixture of (2,4)-cis- and trans-asitrocinones have a configuration of erythro/trans/threo from C-15 to C-20, the mono-THF moiety with two flanking hydroxyl groups. The structures were determined by spectroscopic methods. These acetogenins showed potent bioactivities in the brine shrimp lethality test (BST) and among six human solid tumour cell lines with notable selectivity for the prostate (PC-3) and the pancreatic (MIA PaCa-2) cell lines at 10-100 times the potency of adriamycin.
KW - acetogenins
KW - cell cultures
KW - chemical composition
KW - chemical structure
KW - cytotoxic compounds
KW - cytotoxicity
KW - medicinal plants
KW - neoplasms
KW - non-wood forest products
KW - pancreas
KW - plant composition
KW - prostate
KW - seeds
KW - Asimina triloba
KW - man
KW - Asimina
KW - Annonaceae
KW - Magnoliales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cancers
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - polyketides
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Non-wood Forest Products (KK540)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and analysis of animal materials in food and feed.
AU - Momcilovic, D.
AU - Rasooly, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2000///
VL - 63
IS - 11
SP - 1602
EP - 1609
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Momcilovic, D.: Center of Veterinary Medicine, U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20003025415. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Veterinary Science; Veterinary Science; Public Health
N2 - Bovine spongiform encephalopathy (BSE) belongs to a group of progressively degenerative neurological diseases known as transmissible spongiform encephalopathies (TSEs) associated with a variant form of Creutzfeldt-Jakob disease in humans. TSEs are fatal diseases caused by prions (proteinaceous infectious particle) and are characterized by an incubation period that may range from several months to several years, depending on the host. Because BSE is spread through animal feed, the main strategy for preventing the establishment and spread of BSE is to prohibit the use of proteins derived from mammalian tissue in feed for ruminant animals. Enforcement of these regulations relies on the ability to identify the presence of prohibited proteins in ruminant feed. The methods to detect bovine products in rendered and cooked materials are based on analyses of DNA, bone, or protein. The current methodology as well as other potentially useful methods of analysis of animal material in food are discussed. While methods are generally useful, none specifically distinguish between prohibited bovine material and allowable bovine products, such as milk or blood. Furthermore, all these methods are hampered by the fact that the rendering process involves heat treatment that denatures and degrades proteins and DNA. There is a need for improving existing methods and developing new methods to overcome these two limitations.
KW - analytical methods
KW - animal protein
KW - bovine spongiform encephalopathy
KW - cattle diseases
KW - Creutzfeldt-Jakob disease
KW - feeds
KW - foods
KW - methodology
KW - prion diseases
KW - reviews
KW - spongiform encephalopathy
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - bovine encephalopathy
KW - BSE
KW - feeding stuffs
KW - mad cow disease
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved rapid analytical method for the urinary determination of 3,5,6 trichloro-2-pyridinol, a metabolite of chlorpyrifos.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Biagini, R. E.
AU - Stettler, L. E.
AU - Hines, C. J.
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
Y1 - 2000///
VL - 65
IS - 1
SP - 1
EP - 7
SN - 0007-4861
AD - MacKenzie, B. A.: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20001112213. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 2921-88-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - A method is described which uses β-glucuronidase treatment of urine from individuals occupationally exposed to chlorpyrifos and a simple particle-based immunoassay. This method yielded results which correlated well with a more elaborate, multi-step conventional method, acid hydrolysis followed by analysis for the metabolite 3,5,6-trichloro-2-pyridinol by gas chromatography with mass selective detection.
KW - analytical methods
KW - chlorpyrifos
KW - determination
KW - immunoassay
KW - insecticide residues
KW - insecticides
KW - techniques
KW - urine
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - chlorpyrifos-ethyl
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved template preparation for PCR-based assays for detection of food-borne bacterial pathogens.
AU - Lampel, K. A.
AU - Orlandi, P. A.
AU - Kornegay, L.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2000///
VL - 66
IS - 10
SP - 4539
EP - 4542
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Lampel, K. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 20003010137. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science
KW - beef
KW - contamination
KW - detection
KW - food
KW - food safety
KW - foodborne diseases
KW - polymerase chain reaction
KW - bacteria
KW - Listeria monocytogenes
KW - Salmonella typhimurium
KW - Shigella flexneri
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Shigella
KW - bacterium
KW - PCR
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Environmental investigations of Vibrio parahaemolyticus in oysters after outbreaks in Washington, Texas, and New York (1997 and 1998).
AU - DePaola, A.
AU - Kaysner, C. A.
AU - Bowers, J.
AU - Cook, D. W.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2000///
VL - 66
IS - 11
SP - 4649
EP - 4654
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - DePaola, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20003020176. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Total Vibrio parahaemolyticus densities and the occurrence of pathogenic strains in shellfish were determined following outbreaks in Washington, Texas, and New York. Recently developed nonradioactive DNA probes were utilized for the first time for direct enumeration of V. parahaemolyticus in environmental shellfish samples. V. parahaemolyticus was prevalent in oysters from Puget Sound, Wash.; Galveston Bay, Tex.; and Long Island Sound, N.Y., in the weeks following shellfish-associated outbreaks linked to these areas. However, only two samples (one each from Washington and Texas) were found to harbour total V. parahaemolyticus densities exceeding the level of concern of 10,000 g-1. Pathogenic strains, defined as those hybridizing with tdh and/or trh probes, were detected in a few samples, mostly Puget Sound oysters, and at low densities (usually <10 g-1). Intensive sampling in Galveston Bay demonstrated relatively constant water temperature (27.8 to 31.7°C) and V. parahaemolyticus levels (100 to 1,000 g-1) during the summer. Salinity varied from 14.9 to 29.3 ppt. A slight but significant (P<0.05) negative correlation (-0.25) was observed between V. parahaemolyticus density and salinity. Based on our data, findings of more than 10,000 g-1 total V. parahaemolyticus or >10 g-1tdh- and/or trh-positive V. parahaemolyticus in environmental oysters should be considered extraordinary.
KW - DNA probes
KW - epidemiology
KW - human diseases
KW - outbreaks
KW - oysters
KW - shellfish
KW - temperature
KW - New York
KW - Texas
KW - USA
KW - Washington
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - bacterium
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence differences in the diagnostic target region of the oocyst wall protein gene of Cryptosporidium parasites.
AU - Xiao LiHua
AU - Limor, J.
AU - Morgan, U. M.
AU - Sulaiman, I. M.
AU - Thompson, R. C. A.
AU - Lal, A. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2000///
VL - 66
IS - 12
SP - 5499
EP - 5502
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Xiao LiHua: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20003034004. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology; Veterinary Science; Pig Science; Veterinary Science
N2 - Nucleotide sequences of the Cryptosporidium oocyst wall protein (COWP) gene were obtained from various Cryptosporidium spp. (C. wrairi, C. felis, C. meleagridis, C. baileyi, C. andersoni, C. muris and C. serpentis) and C. parvum genotypes (human, bovine, monkey, marsupial, ferret, mouse, pig and dog). Significant diversity was observed among species and genotypes in the primer and target regions of a popular diagnostic PCR. The results provide useful information for COWP-based molecular differentiation of Cryptosporidium spp. and genotypes.
KW - diagnostic techniques
KW - genes
KW - genetic variation
KW - genotypes
KW - molecular genetics
KW - nucleotide sequences
KW - oocysts
KW - polymerase chain reaction
KW - proteins
KW - carnivores
KW - cattle
KW - Cryptosporidium
KW - Cryptosporidium baileyi
KW - Cryptosporidium muris
KW - Cryptosporidium parvum
KW - dogs
KW - ferrets
KW - man
KW - marsupials
KW - mice
KW - pigs
KW - primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Cryptosporidium
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Mustela
KW - Mustelidae
KW - Homo
KW - Hominidae
KW - Primates
KW - Muridae
KW - rodents
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - biochemical genetics
KW - Cryptosporidium andersoni
KW - Cryptosporidium felis
KW - Cryptosporidium meleagridis
KW - Cryptosporidium serpentis
KW - Cryptosporidium wrairi
KW - cyst wall
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - hogs
KW - PCR
KW - swine
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total folate in enriched cereal-grain products in the United States following fortification.
AU - Rader, J. I.
AU - Weaver, C. M.
AU - Angyal, G.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2000///
VL - 70
IS - 3
SP - 275
EP - 289
SN - 0308-8146
AD - Rader, J. I.: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St., S.W., Washington, DC, USA.
N1 - Accession Number: 20001419478. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition
N2 - The full compliance date for mandatory folic acid fortification of enriched cereal-grain products in the United States was 1 January, 1998. There is currently a great interest in determining the effectiveness of this measure, which was instituted to increase the folate intakes of women of child-bearing age to reduce their risk of having a pregnancy affected by a neural tube birth defect. We surveyed 83 enriched cereal-grain products that are required to be fortified with folic acid under the new regulations and an additional 79 foods that contain enriched cereal-grain ingredients or that are currently fortified with folic acid. Products were collected and analysed between February 1998 and April 1999. Total folate was determined by microbiological assay using a tri-enzyme digestion. We compared analysed values for total folate with amounts required by Federal regulations and/or with label declarations of folate content. For many enriched cereal-grain products, there were significant differences between amounts of folate found on analysis and amounts required by Federal regulations. In part because of this, label declarations of folate content were also in error. The high values found in some enriched cereal-grain products may represent manufacturers' averages as well as the presence of higher-than-expected levels of endogenous folates. These results indicate that reliable food composition databases cannot be developed without extensive new data on the actual concentrations of folate in recently fortified enriched cereal-grain products as well as in products containing enriched cereal-grain ingredients. Reliance on older data bases or on compositional information that has a weak analytical underpinning will lead to unsound estimates of folate intake, and hence, of the potential impact of the new fortification program.
KW - cereal products
KW - cereals
KW - composition
KW - databases
KW - digestion
KW - folic acid
KW - food composition
KW - food products
KW - foods
KW - fortification
KW - intake
KW - pregnancy
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - data banks
KW - folacin
KW - folate
KW - gestation
KW - United States of America
KW - Food Composition and Quality (QQ500)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001419478&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Functional foods: the Food and Drug administration perspective.
AU - Ross, S.
A2 - Harper, A. E.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2000///
VL - 71
SP - 1735S
EP - 1738S
SN - 0002-9165
AD - Ross, S.: Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS 465, 200 C Street, SW, Washington DC 20204, USA.
N1 - Accession Number: 20001419280. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 17 ref. Subject Subsets: Postharvest Research; Human Nutrition
N2 - Because the Federal Food, Drug, and Cosmetic Act (FFDCA) does not provide a statutory definition of functional foods, the Food and Drug Administration has no authority to establish a formal regulatory category for such foods. The primary determinant of the regulatory status of a food is its intended use, which is determined largely by the label and labelling information accompanying the product. This information includes nutrient information, nutrient content claims, and various types of health claims. In marketing these foods, manufacturers may come under one of several existing regulatory options. The first decision manufacturers will make that will help determine their product's regulatory status is whether the product is a food or a drug. Thus, manufacturers and retailers have a range of legal and regulatory categories in which their products may be classified. This article describes the definitions provided in the FFDCA for a drug and a food, the safety and labelling requirements of various food categories, and types of possible claims for dietary supplements.
KW - diets
KW - food supplements
KW - foods
KW - functional foods
KW - health
KW - labelling
KW - legislation
KW - marketing
KW - supplements
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - United States of America
KW - Crop Produce (QQ050)
KW - Laws and Regulations (DD500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A single intramuscular injection of recombinant plasmid DNA induces protective immunity and prevents Japanese encephalitis in mice.
AU - Chang, G. J. J.
AU - Hunt, A. R.
AU - Davis, B.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2000///
VL - 74
IS - 9
SP - 4244
EP - 4252
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Chang, G. J. J.: P.O. Box 2087, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Foothill Campus, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 20013135605. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - Plasmid vectors containing Japanese encephalitis virus (JEV) premembrane (prM) and envelope (E) genes were constructed that expressed prM and E proteins under the control of a cytomegalovirus immediate-early gene promoter. COS-1 cells transformed with this plasmid vector (JE-4B clone) secreted JEV-specific extracellular particles (EPs) into the culture media. Groups of outbred ICR mice (5 per group) were given one or two doses of recombinant plasmid DNA or two doses of the commercial vaccine JEVAX. All mice that received one or two doses of DNA vaccine maintained JEV-specific antibodies 18 months after initial immunization. JEVAX induced 100% seroconversion in 3-week-old mice (n=10); however, none of the 3-day-old mice (n=10) had enzyme-linked immunosorbent assay titres higher than 1:400. Female mice immunized with this DNA vaccine developed plaque reduction neutralization antibody titres of between 1:20 and 1:160 and provided 45 to 100% passive protection to their progeny following intraperitoneal challenge with 5000 PFU of virulent JEV strain SA14. Seven-week-old adult mice that had received a single dose of JEV DNA vaccine when 3 days of age were completely protected from a 50 000-PFU JEV intraperitoneal challenge. These results demonstrate that a recombinant plasmid DNA which produced JEV EPs in vitro is an effective vaccine.
KW - disease models
KW - DNA vaccines
KW - experimental infections
KW - immune response
KW - immunization
KW - Japanese encephalitis
KW - laboratory animals
KW - passive immunity
KW - plasmid vectors
KW - recombinant DNA
KW - vaccines
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incorporation of HLA-DR into the envelope of human immunodeficiency virus type 1 in vivo: correlation with stage of disease and presence of opportunistic infection.
AU - Lawn, S. D.
AU - Butera, S. T.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2000///
VL - 74
IS - 21
SP - 10256
EP - 10259
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Lawn, S. D.: Mail-Stop G19, HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Rd., NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 20013161124. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - Human immunodeficiency virus type 1 (HIV-1) bearing HLA-DR in its envelope was detected in plasma from all patients from Georgia, USA with chronic HIV-1 infection (n=16) and was present at higher levels in patients with active tuberculosis coinfection (n=6) [date not given]. Intriguingly, however, HLA-DR was not detectable in HIV-1 from patients during primary viraemia (n=6), suggesting the possibility of virus replication in less-activated cells.
KW - HIV-1 infections
KW - human diseases
KW - immunocompromised hosts
KW - opportunistic infections
KW - tuberculosis
KW - viraemia
KW - Georgia
KW - USA
KW - Human immunodeficiency virus 1
KW - man
KW - Mycobacterium tuberculosis
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - bacterium
KW - human immunodeficiency virus type 1
KW - United States of America
KW - viremia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013161124&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of amoxicillin residues in animal tissues by solid-phase extraction and liquid chromatography with fluorescence detection.
AU - Luo WenHong
AU - Ang, C. Y. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 1
SP - 20
EP - 25
SN - 1060-3271
AD - Luo WenHong: U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20002209892. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7. Subject Subsets: Veterinary Science; Poultry; Pig Science; Veterinary Science; Human Nutrition
N2 - Trace levels of amoxicillin residues were determined in animal tissues by liquid chromatography (LC) with fluorescence detection. An improved solid-phase extraction (SPE) procedure requiring less flammable solvent (diethyl ether) was developed for sample preparation. Muscle samples of beef, pork, chicken and tilapia were extracted with a phosphate buffer followed by the modified SPE procedure for cleanup and concentration before the LC-fluorescence analysis. Average recoveries of fortified amoxicillin at 5, 10 and 20 µg/kg ranged from 83.9 to 85.8% in beef, 86.1 to 88.1% in pork, 81.7 to 82.9% in chicken and 92.5 to 95.4% in tilapia. Relative standard deviations were <4%.
KW - amoxicillin
KW - analytical methods
KW - animal tissues
KW - antibiotics
KW - beef
KW - chicken meat
KW - determination
KW - drug residues
KW - fish
KW - fluorescence
KW - liquid chromatography
KW - muscles
KW - pigmeat
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - amoxycillin
KW - analytical techniques
KW - chickens
KW - domesticated birds
KW - pork
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Meat Produce (QQ030)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Meat Producing Animals (LL120)
KW - Aquatic Produce (QQ060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002209892&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of residues of chloramphenicol, florfenicol, florfenicol amine, and thiamphenicol in shrimp tissue by gas chromatography with electron capture detection.
AU - Pfenning, A. P.
AU - Roybal, J. E.
AU - Rupp, H. S.
AU - Turnipseed, S. B.
AU - Gonzales, S. A.
AU - Hurlbut, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 1
SP - 26
EP - 30
SN - 1060-3271
AD - Pfenning, A. P.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20002209893. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 56-75-7, 73231-34-2, 76639-94-6, 15318-45-3. Subject Subsets: Veterinary Science; Human Nutrition
N2 - A gas chromatographic (GC) method is presented for determining residues of chloramphenicol (CAP), florfenicol (FF), florfenicol amine (FFa) and thiamphenicol (TAP) in shrimp tissues, with meta-nitrochloramphenicol (mCAP) as the internal standard. The composited shrimp is extracted with basic ethyl acetate, followed by an acetonitrile-basic ethyl acetate mixture. This extract is centrifuged, filtered, evaporated and reconstituted in water; the reconstituted extract is acidified, defatted with hexane, and passed through a propylsulfonic acid (PRS) and C18 solid-phase extraction (SPE) system. The C18 SPE column is eluted with methanol and the PRS SPE column is eluted with basic MeOH plus counter ion. The combined eluates are evaporated, reconstituted in acetonitrile and derivatized with Sylon BFT. After derivatization, the addition of toluene directly to the sample, followed by the addition of basic water, quenches the derivatization process. After centrifugation, the organic layer is carefully removed and the analytes are determined by GC with electron capture detection. Shrimp tissues were fortified with fenicols (i.e., CAP, FF, FFa, and TAP) at 5, 10, 20, 40 and 80 ng/ml. Overall recoveries were 88, 101, 91 and 84% with overall interassay (between-day) variabilities (i.e., relative standard deviations) of 5.3, 9.4, 12.8 and 7.4% for CAP, FF, FFa and TAP, respectively. The method detection limits were calculated as 0.7, 1.4, 2.4 and 1.3 ng/g (ppb) for CAP, FF, FFa and TAP, respectively, based on a 10 g sample. The quantitation limit as determined empirically by this method is the lower limit of the standard curve, which is about 5 ng/g for each analyte.
KW - analytical methods
KW - antibiotics
KW - chloramphenicol
KW - determination
KW - drug residues
KW - florfenicol
KW - gas chromatography
KW - quantitative techniques
KW - shellfish
KW - shrimps
KW - thiamphenicol
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - analytical techniques
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Capillary gas chromatography/mass spectrometry with chemical ionization and negative ion detection for confirmation of identity of patulin in apple juice.
AU - Roach, J. A. G.
AU - White, K. D.
AU - Trucksess, M. W.
AU - Thomas, F. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 1
SP - 104
EP - 112
SN - 1060-3271
AD - Roach, J. A. G.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001202243. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 149-29-1. Subject Subsets: Medical & Veterinary Mycology
N2 - Gas chromatography/mass spectrometry (GC/MS) with negative ion chemical ionization permits detection of underivatized patulin in apple juice extracts while minimizing co-extractive responses. The technique has been used with a variety of capillary columns in quadrupole, ion trap, and magnetic sector GC/MS instruments to confirm presumptive findings of patulin in apple juice at concentrations ranging from 68 to 3700 µg/litre. The demonstrated ability to use any of these 3 mass spectrometers and several capillary columns to confirm the identity of patulin are significant strengths of the technique.
KW - apple juice
KW - contamination
KW - detection
KW - estimation
KW - extracts
KW - gas chromatography
KW - mass spectrometry
KW - methodology
KW - mycotoxins
KW - patulin
KW - techniques
KW - fungal toxins
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Storage Problems and Pests of Food (QQ111)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001202243&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Element and radionuclide concentrations in food: FDA total diet study 1991-1996.
AU - Capar, S. G.
AU - Cunningham, W. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 1
SP - 157
EP - 177
SN - 1060-3271
AD - Capar, S. G.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Elemental Research Branch (HFS-338), Washington, DC 20204, USA.
N1 - Accession Number: 20001410381. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Foods (milk products, meat products, fruit, vegetables, beverages) purchased throughout the United States during 1991-1997 under the US Food and Drug Administration's Total Diet Study (TDS) program were analysed for elements and radionuclides. The program is described with emphasis on food analysis and quality control, including independent interlaboratory exercises. Analytical results are summarised for Cd, Pb, Ni, As, Hg, Se, Cu, Zn, Mn, Fe, Mg, Ca, P, K, and Na and for 137Cs, 131I, 106Ru, and 90Sr. Concentration data are provided to expand the information base used to support assessments of the safety and nutritive value of the U.S. food supply and for their potential use in food composition databases. For selected foods, comparisons were made with past TDS results and with those reported in the literature. An extensive listing of the analytical data is available on the FDA CFSAN Website.
KW - beverages
KW - comparisons
KW - composition
KW - contamination
KW - databases
KW - diet studies
KW - food composition
KW - food contamination
KW - food products
KW - food supply
KW - foods
KW - fruit
KW - meat products
KW - milk products
KW - nutritive value
KW - quality
KW - quality controls
KW - radionuclides
KW - residues
KW - vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - data banks
KW - drinks
KW - food contaminants
KW - nutritional value
KW - quality assurance
KW - quality for nutrition
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - United States of America
KW - vegetable crops
KW - Food Science and Food Products (Human) (QQ000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001410381&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibiotic use in food animals: controlling the human health impact.
AU - Tollefson, L.
AU - Miller, M. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 2
SP - 245
EP - 254
SN - 1060-3271
AD - Tollefson, L.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, 7500 Standish P1, Rockville, MD 20855, USA.
N1 - Accession Number: 20002215777. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Veterinary Science
N2 - The history of antimicrobial use and regulation in animals, the public health concern, the current animal drug approval process in the United States, the international perspective and the U.S. Food and Drug Administration's proposed procedures to evaluate the human health impact of antimicrobial effects associated with animal drugs intended for use in food-producing animals is described. The primary public health goal of the improved regulatory paradigm is to ensure that significant human antimicrobial therapies are not lost due to use of antimicrobials in food animals.
KW - antibiotics
KW - antiinfective agents
KW - antimicrobial properties
KW - approval schemes
KW - drug resistance
KW - drugs
KW - foodborne diseases
KW - history
KW - public health
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anti-microbial properties
KW - antimicrobials
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Accelerated solvent extraction of vitamin K1 in medical foods in conjunction with matrix solid-phase dispersion.
AU - Chase, G. W., Jr.
AU - Thompson, B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 2
SP - 407
EP - 410
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 20001415243. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 12001-79-5. Subject Subsets: Human Nutrition
N2 - An extraction technique is described for vitamin K1 in medical foods, using accelerated solvent extraction (ASE) in conjunction with matrix solid-phase dispersion (MSPD). The medical food sample is treated as it would be with MSPD extraction, followed by ASE for a hands-free automated extraction. The vitamin K1 in the ASE extract is then quantitated by reversed-phase liquid chromatography with fluorescence detection. The chromatography specifications are identical to those in previous work that used MSPD only, with a limit of detection of 6.6 pg and a limit of quantitation of 22 pg on column. Recoveries, which were determined for an analyte-fortified zero control reference material for medical foods, averaged 97.6% (n=25) for vitamin K1. The method provides a rapid, automatic, specific, and easily controlled assay for vitamin K1 in fortified medical foods with minimal solvent usage.
KW - analytical methods
KW - automation
KW - foods
KW - vitamin K
KW - analytical techniques
KW - Techniques and Methodology (ZZ900)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001415243&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of patulin and 5-hydroxymethylfurfural in apple juice by gas chromatography/mass spectrometry.
AU - Rupp, H. S.
AU - Turnipseed, S. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 3
SP - 612
EP - 620
SN - 1060-3271
AD - Rupp, H. S.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021, USA.
N1 - Accession Number: 20001203426. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 67-47-0, 149-29-1. Subject Subsets: Medical & Veterinary Mycology
N2 - A gas chromatographic/mass spectrometric (GC/MS) method was developed for the confirmation of patulin and 5-hydroxymethylfurfural (HMF) extracted from apple juice. The extraction is based on the official AOAC method for liquid chromatographic analysis. Juice extracts are quickly and easily derivatized with bis(trimethyl-silyl)trifluoracetamide under mild conditions, and the trimethylsilyl ethers of the analytes are stable for at least several hours. The analytes are determined by GC/MS using an electron-impact source and selected ion monitoring of characteristic ions. For both analytes, the interassay differences between base-peak ratios for samples and standards were all <7.1% (absolute). The presence of patulin was confirmed at fortification levels of approx. 30-400 µg/litre and naturally occurring levels of approx. 80-400 µg/litre. The presence of HMF was also confirmed at levels ≤2 mg/litre. The proposed mass spectral fragmentation pathways of the analytes are presented.
KW - apple juice
KW - contamination
KW - estimation
KW - gas chromatography
KW - HMF
KW - mass spectrometry
KW - methodology
KW - mycotoxins
KW - patulin
KW - techniques
KW - fungal toxins
KW - hydroxymethylfurfural
KW - methods
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001203426&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of dehydroepiandrosterone (DHEA) in dietary supplement products.
AU - Thompson, R. D.
AU - Carlson, M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 4
SP - 847
EP - 857
SN - 1060-3271
AD - Thompson, R. D.: U.S. Food and Drug Administration, 240 Hennepin Ave, Minneapolis, MN 55401, USA.
N1 - Accession Number: 20001419819. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 57-88-5, 53-43-0. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic (LC) method was developed to assess the potency of products that contain dehydroepiandrosterone (DHEA), a precursor hormone synthesized from cholesterol by the human adrenal cortex and converted to potent androgens and/or oestrogens in peripheral tissues. 45 commercial products (single- and multi-ingredient) were subjected to analysis by the proposed method. A Zorbax Rx C18 column with a mobile phase containing acetonitrile-0.025 M phosphate buffer (60+40), pH 3.50, and ultraviolet detection at 292 nm was used for 87% of the products. An alternative mobile phase containing methanol-0.025 M phosphate (75+25), pH 3.50, was used to isolate DHEA from more complex product mixtures. Assay values varied from 0 to 109.5% of the declared amount with an overall mean value of 91.1%. The recoveries based on fortified products ranged from 96.4 to 101.2%, and the intraday precision (RSD, n=5) varied from 0.50 to 1.66%.
KW - analytical methods
KW - androgens
KW - cholesterol
KW - hormones
KW - liquid chromatography
KW - oestrogens
KW - prasterone
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - dehydroepiandrosterone
KW - estrogens
KW - Physiology of Human Nutrition (VV120)
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of vitamin K1 in medical foods by liquid chromatography with postcolumn reduction and fluorometric detection.
AU - Ware, G. M.
AU - Chase, G. W.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 4
SP - 957
EP - 962
SN - 1060-3271
AD - Ware, G. M.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20000406119. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 84-80-0, 12001-79-5. Subject Subsets: Human Nutrition; Dairy Science
N2 - A liquid chromatographic (LC) method is described for the determination of vitamin K1 in medical foods. The sample is enzymatically digested with lipase and α-amylase and extracted with 1% sodium bicarbonate solution-isopropanol (1+1). After C18 solid-phase extraction, vitamin K1 is separated by nonaqueous reversed-phase LC, converted to the hydroquinone by postcolumn zinc reduction, and quantitated by fluorescence detection. The limit of detection is 8 pg (3 σ), and the limit of quantitation is 27 pg (10 σ) on column. Linear response ranged from 0.1 to 1.0 ng vitamin K1 (r=0.9999). The mean recovery (n=38) for all spiking levels was 101.6±2.85%. Analysis of Standard Reference Material 1846, Infant Formula, gave a mean value of 0.95±0.088 mg vitamin K/kg with a coefficient of variation of 9.26.
KW - analytical methods
KW - foods
KW - infant formulae
KW - liquid chromatography
KW - pharmaceutical products
KW - phylloquinone
KW - vitamin K
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - phytonadione
KW - United States of America
KW - vitamin K1
KW - Milk and Dairy Produce (QQ010)
KW - Physiology of Human Nutrition (VV120)
KW - Techniques and Methodology (ZZ900)
KW - Other Produce (QQ070)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Revalidation and long-term stability of National Institute of Standards and Technology Standard Reference Materials 1566, 1567, 1568, and 1570.
AU - Anderson, D. L.
AU - Cunningham, W. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 5
SP - 1121
EP - 1134
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Anderson, D. L.: U.S. Food and Drug Administration, Elemental Research Branch (HFS-338), Washington, DC 20204, USA.
N1 - Accession Number: 20003008858. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts; Rice
N2 - Multiple units of Standard Reference Materials (SRMs) 1566 Oyster Tissue, 1567 Wheat Flour, 1568 Rice Flour, and 1570 Trace Elements in Spinach, produced by the US National Institute of Standards and Technology (NIST, then the National Bureau of Standards), were analysed 17-20 years after the original certification dates and 12-15 years after the certificates became invalid. Instrumental neutron activation analysis and thermal neutron prompt γ-ray activation analysis were used to measure mass fractions for 27 elements in these SRMs to revalidate them for use in quality assurance (QA) programs required for food analysis programs within the US Food and Drug Administration. With the exception of Se in SRM 1567, all element mass fractions were in agreement with certified values and literature data. Some evidence of B loss from SRM 1568 was observed. These materials were judged to be suitable for continued use in QA programs. Findings showed that these matrixes exhibited stability of moisture, mass fraction, and weight basis for far longer (≥15 years) than was indicated by the 5-year validity statement on the NIST Certificates of Analysis.
KW - analysis
KW - chemical composition
KW - oysters
KW - quality controls
KW - reference standards
KW - rice flour
KW - spinach
KW - stability
KW - wheat flour
KW - Spinacia oleracea
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - quality assurance
KW - revalidation
KW - standard reference materials
KW - Food Composition and Quality (QQ500)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sulfite in Oriental herbal medicines.
AU - Kim YoungKyung
AU - Koh EunMi
AU - Park SangYong
AU - Chang SeungYeup
AU - Park SooJin
AU - Na WonIl
AU - Kim HieJoon
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 5
SP - 1149
EP - 1154
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Kim YoungKyung: Korea Food and Drug Administration, Eunpyung-ku, Seoul 122-020, Korea Republic.
N1 - Accession Number: 20003007275. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Sulfite was detected in 7 Oriental herbal medicines (Pueraria radix, Zingiberis rhizoma, Platycodon radix, Adenophora radix, Pinellia tuber, Astragalus radix, and Paeonia radix) on the Korean market. Sulfiting of commercial Oriental herbal medicines by fumigation with burning bituminous coal was simulated, and the accumulation of sulfite was investigated by using fresh Platycodon radix roots obtained from the field. The sulfite level reached a plateau in 9 h, and the maximum sulfite level found by the Monier-Williams (MW) method (AOAC 990.28) was 1020 ppm. The sulfite content in the simulated Platycodon radix sample determined by alkali extraction followed by ion-exclusion chromatography with electrochemical detection (AOAC 990.31) was approximately 17% lower on average than the MW results. Free-sulfite levels determined by acid extraction and ion-exclusion chromatography with electrochemical detection were between 19 and 49% of the MW results. The advantages of different methods for sulfite determination and the significance of the results are discussed.
KW - chemical composition
KW - chromatography
KW - herbal drugs
KW - medicinal plants
KW - plant composition
KW - quality
KW - rhizomes
KW - roots
KW - sulfites
KW - Korea Republic
KW - Adenophora
KW - Astragalus
KW - Paeonia
KW - Pinellia
KW - Platycodon
KW - Pueraria
KW - Zingiber
KW - Campanulaceae
KW - Campanulales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Paeoniaceae
KW - Dilleniales
KW - Araceae
KW - Arales
KW - monocotyledons
KW - Zingiberaceae
KW - Zingiberales
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - chemical constituents of plants
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Paeoniales
KW - South Korea
KW - sulphites
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic preparative method for isolating ergot alkaloids, using a particle-loaded membrane extracting disk.
AU - Ware, G. M.
AU - Price, G.
AU - Carter, L., Jr.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 6
SP - 1395
EP - 1399
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Ware, G. M.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St., Atlanta, GA 30309, USA.
N1 - Accession Number: 20013002094. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 60-79-7. Subject Subsets: Postharvest Research; Plant Pathology; Medical & Veterinary Mycology
N2 - A liquid chromatographic method is described for the determination of ergot alkaloids in wheat. Ergonovine, ergotamine, ergocornine, α-ergocryptine and ergocristine are extracted from wheat with methanol-0.25% concentrated H3PO4 (40+60) pH 2.2, cleaned up by using a solid-phase extraction (SPE) disk, and separated by reversed-phase liquid chromatography with fluorescence detection. Ergot alkaloids are basic compounds that form water-soluble salts in acidic aqueous solution. Because ergot alkaloid salts are positively charged, they can be easily and selectively trapped on a negatively charged strong cation-exchange SPE disk. A strong wash solvent, methanol-0.25% concentrated H3PO4 (40+60) was used to remove matrix interferences not bonded by ionic interactions with the cation-exchange column. The ergot alkaloids were eluted from the ion-exchange column by adjusting the pH of the elution solvents to slightly basic conditions (pH 9). The SPE disk concentrated and cleanly separated the ergot alkaloids from matrix interferences. Standard calibration curves for ergot alkaloids for the concentration range 0.1-2.0 µg/ml were linear. The SPE disk had a column capacity equivalent to about 1 g extracted wheat. At spiking levels of 2.3-46 ng/g for ergonovine and 20-400 ng/g for ergotamine, ergocornine, α-ergocryptine and ergocristine, the mean recovery was 88.1% with a coefficient of variation (CV) of 5.33%. The recovery data ranged from 79.1 to 95.9%. Ergonovine had the lowest overall recovery and the largest CV. The method has an estimated reliable limit of detection and limit of quantitation of <5 and <20 ng/g, respectively, for each ergot alkaloid tested.
KW - detection
KW - ergometrine
KW - ergot alkaloids
KW - estimation
KW - liquid chromatography
KW - mycotoxins
KW - techniques
KW - ergocornine
KW - ergocristine
KW - ergocryptine
KW - ergonovine
KW - ergot derivatives
KW - ergotamine
KW - fungal toxins
KW - Techniques and Methodology (ZZ900)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Resistance of Pseudomonas aeruginosa to liquid disinfectants on contaminated surfaces before formation of biofilms.
AU - Sagripanti, J. L.
AU - Bonifacino, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 6
SP - 1415
EP - 1422
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Sagripanti, J. L.: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, Division of Life Sciences, Molecular Biology Branch (HF2-113), 12709 Twinbrook Parkway, Rockville, MD 20852, USA.
N1 - Accession Number: 20013011250. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 50-00-0, 79-21-0, 7681-52-9.
N2 - A comparison was made of the effectiveness of popular disinfectants (Cavicide, Cidexplus, Clorox, Exspor, Lysol, Renalin, and Wavicide) under conditions prescribed for disinfection in the respective product labels on Pseudomonas aeruginosa either in suspension or deposited onto surfaces of metallic or polymeric plastic devices. The testing also included 7 nonformulated germicidal agents (glutaraldehyde, formaldehyde, peracetic acid, hydrogen peroxide, sodium hypochlorite, phenol, and cupric ascorbate) commonly used in disinfection and decontamination. Results showed that P. aeruginosa is on average 300-fold more resistant when present on contaminated surfaces than in suspension. This increase in resistance agrees with results reported in studies of biofilms, but unexpectedly, it precedes biofilm formation. The surface to which bacteria are attached can influence the effectiveness of disinfectants. Viable bacteria attached to devices may require dislodging through more than a one-step method for detection. The data, obtained with a sensitive and quantitative test, suggest that disinfectants are less effective on contaminated surfaces than generally acknowledged.
KW - biofilms
KW - disinfectants
KW - disinfection
KW - formaldehyde
KW - labelling
KW - peracetic acid
KW - sodium hypochlorite
KW - Pseudomonas aeruginosa
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - labeling
KW - labels
KW - peroxyacetic acid
KW - Microbiology (General) (ZZ390)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating presence/absence of target microbes in microbiological tests.
AU - Blodgett, R. J.
AU - Hitchins, A. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2000///
VL - 83
IS - 6
SP - 1429
EP - 1433
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Blodgett, R. J.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013011254. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - A typical qualitative microbiological method performance (collaborative) study gathers a data set of responses about a test for the presence or absence of a target microbe. Two models were developed that estimate false-positive and false-negative rates. One model assumes a constant probability that the tests will indicate the target microbe is present for any positive concentration in the test portion. The other assumes that this probability follows a logistic curve. Test results from several method performance studies on foods and milk illustrate these estimates.
KW - analytical methods
KW - foods
KW - microbial contamination
KW - milk
KW - models
KW - analytical techniques
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Attempts to establish experimental Cyclospora cayetanensis infection in laboratory animals.
AU - Eberhard, M. L.
AU - Ortega, Y. R.
AU - Hanes, D. E.
AU - Nace, E. K.
AU - Do Quy
AU - Robl, M. G.
AU - Won, K. Y.
AU - Gavidia, C.
AU - Sass, N. L.
AU - Mansfield, K.
AU - Gozalo, A.
AU - Griffiths, J.
AU - Gilman, R.
AU - Sterling, C. R.
AU - Arrowood, M. J.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2000///
VL - 86
IS - 3
SP - 577
EP - 582
SN - 0022-3395
AD - Eberhard, M. L.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20000809446. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Pig Science; Poultry; Public Health; Tropical Diseases; Protozoology
N2 - Cyclospora cayetanensis oocysts collected from stools of infected humans in the USA, Haiti, Guatemala, Peru and Nepal were held in potassium dichromate solution to allow development of sporozoites. The following animals were inoculated: 9 strains of mice, including adult and neonatal immunocompetent and immune-deficient inbred and outbred strains, rats, sandrats, chickens, ducks, rabbits, Meriones unguiculatus, hamsters, ferrets, pigs, dogs, owl monkeys, rhesus monkeys, and cynomolgus monkeys. Most animals were inoculated by gavage, although some of the primates were fed oocysts on food items. The animals were examined for signs of infection, particularly diarrhoea, and stool samples were examined for 4-6 weeks pi. None developed patent infections or signs of infection.
KW - disease models
KW - experimental infections
KW - human diseases
KW - introduced species
KW - laboratory animals
KW - oocysts
KW - poultry
KW - sporozoites
KW - Guatemala
KW - Haiti
KW - Nepal
KW - Peru
KW - USA
KW - animals
KW - Aotus trivirgatus
KW - Cyclospora cayetanensis
KW - dogs
KW - ducks
KW - ferrets
KW - fowls
KW - hamsters
KW - Macaca fascicularis
KW - Macaca mulatta
KW - Meriones unguiculatus
KW - mice
KW - pigs
KW - Primates
KW - Psammomys
KW - rabbits
KW - rats
KW - eukaryotes
KW - Aotus
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Cyclospora
KW - Eimeriidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Anatidae
KW - Anseriformes
KW - birds
KW - Mustela
KW - Mustelidae
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - Cricetinae
KW - Muridae
KW - rodents
KW - Macaca
KW - Cercopithecidae
KW - Meriones
KW - Gerbillinae
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Leporidae
KW - Lagomorpha
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Caribbean Community
KW - Hispaniola
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Least Developed Countries
KW - South Asia
KW - Asia
KW - Andean Group
KW - APEC countries
KW - South America
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - chickens
KW - domesticated birds
KW - exotic organisms
KW - exotic species
KW - hogs
KW - introduced organisms
KW - non-indigenous organisms
KW - non-indigenous species
KW - non-native organisms
KW - non-native species
KW - nonindigenous organisms
KW - nonindigenous species
KW - sandrats
KW - swine
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A comprehensive systematic approach to identification of influenza A virus genotype using RT-PCR and RFLP.
AU - Offringa, D. P.
AU - Tyson-Medlock, V.
AU - Ye ZhiPing
AU - Levandowski, R. A.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2000///
VL - 88
IS - 1
SP - 15
EP - 24
SN - 0166-0934
AD - Offringa, D. P.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM 463, Rockville, MD 20852, USA.
N1 - Accession Number: 20002013325. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Agricultural Biotechnology
N2 - Amplification of influenza A virus gene segments by reverse transcription-polymerase chain reaction (RT-PCR) can be combined with enzymatic digestion to reveal unique restriction fragment length polymorphisms specific for H1N1 and H3N2 subtype viruses. We have used the method to provide a rapid, specific and reproducible identification of the genotype of high-growth influenza reassortants derived from A/Puerto Rico/8/34 (PR8). Digestion of the gene segments amplified from wild-type viruses, PR8 and reassortants at sites unique to either the wild-type strain or to PR8 provided positive, unambiguous identification of the origin of each of the internal genes, and distinguished the internal genes of both H1N1 and H3N2 strains from those of PR8. This method has also permitted us to quickly confirm that reassorting has occurred and to optimize the selection of reassortant clones with maximum number of PR8 internal genes. Since the method can detect 1-10% of a second strain in a mixed population, the method can also be used to detect samples containing more than one viral subtype and to assess the purity of influenza viruses used for manufacturing vaccines.
KW - clones
KW - genes
KW - genotypes
KW - human diseases
KW - identification
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - strains
KW - vaccines
KW - influenzavirus A
KW - man
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - PCR
KW - RFLP
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of food fortification in the United States: the case of pellagra.
AU - Park, Y. K.
AU - Sempos, C. T.
AU - Barton, C. N.
AU - Vanderveen, J. E.
AU - Yetley, E. A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000///
VL - 90
IS - 5
SP - 727
EP - 738
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Park, Y. K.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Office of Nutritional Products, Labeling and Dietary Supplements, 200 C St SW, HFS-832, Washington, DC 20204, USA.
N1 - Accession Number: 20023078934. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 59-67-6, 12001-76-2. Subject Subsets: Public Health; Human Nutrition
N2 - Objectives: We evaluated the possible role of niacin fortification of the US food supply and other concurrent influences in eliminating the nutritional deficiency disease pellagra. Methods: We traced chronological changes in pellagra mortality and morbidity and compared them with the development of federal regulations, state laws, and other national activities pertaining to the fortification of cereal-grain products with niacin and other B vitamins. We also compared these changes with other concurrent changes that would have affected pellagra mortality or morbidity. Results: The results show the difficulty of evaluating the effectiveness of a single public health initiative such as food fortification without controlled experimental trials. Nonetheless, the results provide support for the belief that food fortification played a significant role in the elimination of pellagra in the United States. Conclusions: Food fortification that is designed to restore amounts of nutrients lost through grain milling was an effective tool in preventing pellagra, a classical nutritional deficiency disease, during the 1930s and 1940s, when food availability and variety were considerably less than are currently found in the USA.
KW - cereals
KW - fortification
KW - human diseases
KW - morbidity
KW - mortality
KW - nicotinic acid
KW - pellagra
KW - vitamin B complex
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - niacin
KW - United States of America
KW - vitamin B
KW - Crop Produce (QQ050)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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UR - email: ypark@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parasitic diseases: opportunities and challenges in the 21st century.
AU - Colley, D. G.
JO - Memórias do Instituto Oswaldo Cruz
JF - Memórias do Instituto Oswaldo Cruz
Y1 - 2000///
VL - 95
IS - Suppl. I
SP - 79
EP - 87
CY - Rio de Janeiro; Brazil
PB - Casa de Oswaldo Cruz
SN - 0074-0276
AD - Colley, D. G.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Building 102, MS F-22, Atlanta, GA 30341, USA.
N1 - Accession Number: 20003030136. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 65 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Helminthology; Public Health; Tropical Diseases
N2 - This review considers some recent contributions to parasitological research in the fields of molecular biology, cell biology, immunology and drug development. Disease control is dependent on the ability of suitable tools, epidemiological vulnerability, availability of sustained funding and political will. Current control programmes cover dracunculiasis (Dracunculus medinensis), onchocerciasis (Onchocerca volvulus), Chagas' disease (Trypanosoma cruzi) and lymphatic filariasis (Wuchereria bancrofti, Brugia malayi); initiated programmes include malaria (Plasmodium spp.) and soil-transmitted Nematoda, planned programmes include schistosomiasis (Schistosoma spp.) and possible programmes include taeniasis and cysticercosis (Taenia spp.), echinococcosis (Echinococcus spp.), African trypanosomiasis (T. rhodesiense and T. gambiense) and visceral leishmaniasis (Leishmania spp.). Future challenges include parasite genome sequencing and genetic analysis, vaccine development, vector management, drug resistance, and social aspects such as sanitation, public health, housing and funding.
KW - cellular biology
KW - Chagas' disease
KW - conferences
KW - control programmes
KW - cysticercosis
KW - disease control
KW - dracunculiasis
KW - drug resistance
KW - echinococcosis
KW - filariasis
KW - funding
KW - helminths
KW - housing
KW - human diseases
KW - immunology
KW - malaria
KW - molecular biology
KW - molecular genetics
KW - new drugs
KW - onchocerciasis
KW - parasites
KW - parasitology
KW - public health
KW - research
KW - reviews
KW - sanitation
KW - schistosomiasis
KW - taeniasis
KW - trypanosomiasis
KW - vaccine development
KW - vector control
KW - visceral leishmaniasis
KW - Brugia malayi
KW - Dracunculus medinensis
KW - Echinococcus
KW - Leishmania
KW - man
KW - Nematoda
KW - Onchocerca volvulus
KW - Plasmodium
KW - Schistosoma
KW - Taenia
KW - Trypanosoma cruzi
KW - Trypanosoma gambiense
KW - Trypanosoma rhodesiense
KW - Wuchereria bancrofti
KW - Brugia
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dracunculus
KW - Dracunculidae
KW - Taeniidae
KW - Eucestoda
KW - Cestoda
KW - Platyhelminthes
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Onchocerca
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Trypanosoma
KW - Wuchereria
KW - bilharzia
KW - bilharziasis
KW - biochemical genetics
KW - cell biology
KW - control programs
KW - dracontiasis
KW - Guinea worm
KW - guinea worm disease
KW - guinea worm infection
KW - hydatid disease
KW - hydatidosis
KW - nematodes
KW - onchocercosis
KW - parasitic worms
KW - river blindness
KW - schistosomosis
KW - Secernentea
KW - Spirurida
KW - Strigeida
KW - studies
KW - taeniosis
KW - trypanosomosis
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Health Services (UU350)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003030136&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food sources of added sweeteners in the diets of Americans.
AU - Guthrie, J. F.
AU - Morton, J. F.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2000///
VL - 100
IS - 1
SP - 43
EP - 51
SN - 0002-8223
AD - Guthrie, J. F.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC, USA.
N1 - Accession Number: 20001409550. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Sugar Industry
N2 - Mean intakes of added sweeteners from all food sources and from specific food categories; percentage contribution of added sweeteners to total energy intake; and percentage contribution of each food category to total intake of added sweeteners were calculated using the USDA Food Guide Pyramid servings database. All analyses were conducted for a national sample of non-institutionalized persons aged 2 years and older (n=15 010) and for 12 age-gender groups (1994-96). Each subject provided one 24-h dietary recall. During 1994 to 1996, Americans aged 2 years and older consumed the equivalent of 82 g carbohydrate per day from added sweeteners, which accounted for 16% of total energy intake. In absolute terms, adolescent males consumed the most; as a percentage of energy, male and female adolescents had the highest intakes (averaging 20% of total energy from added sweeteners). The largest source of added sweeteners was regular soft drinks, which accounted for one third of intake. Other sources were table sugars, syrups, and sweets; sweetened grains; regular fruitades/drinks; and milk products. It is concluded that intakes of added sweeteners exceed levels compatible with meeting current dietary recommendations. Knowing food sources of added sweeteners for the overall population and for specific age-gender groups can help dietitians provide appropriate nutrition education.
KW - adolescents
KW - adults
KW - beverages
KW - children
KW - consumption
KW - diet
KW - energy intake
KW - food additives
KW - foods
KW - guidelines
KW - men
KW - milk products
KW - soft drinks
KW - sugar substitutes
KW - sweeteners
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - drinks
KW - recommendations
KW - teenagers
KW - United States of America
KW - Food Additives (QQ130)
KW - Food Science and Food Products (Human) (QQ000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001409550&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessing food selection in a health promotion program: validation of a brief instrument for American Indian children in the Southwest United States.
AU - Koehler, K. M.
AU - Cunningham-Sabo, L.
AU - Lambert, L. C.
AU - McCalman, R.
AU - Skipper, B. J.
AU - Davis, S. M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2000///
VL - 100
IS - 2
SP - 205
EP - 211
SN - 0002-8223
AD - Koehler, K. M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-728, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001413999. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition
N2 - Brief dietary assessment instruments are needed to evaluate behavior changes of participants in dietary intervention programs. The purpose of this project was to design and validate an instrument for children participating in Pathways to Health, a culturally appropriate, cancer prevention curriculum. Validation of a brief food selection instrument, Yesterday's Food Choices (YFC), which contained 33 questions about foods eaten the previous day with response choices of yes, no, or not sure. Reference data for validation were 24-hour dietary recalls administered individually to 120 students selected randomly. The YFC and 24-hour dietary recalls were administered to American Indian children in fifth- and seventh-grade classes in the Southwest United States. Dietary recalls were coded for food items in the YFC and results were compared for each item using percentage agreement and the κ statistic. Percentage agreement for all items was greater than 60%; for most items it was greater than 70%, and for several items it was greater than 80%. The amount of agreement beyond that explained by chance (κ statistic) was generally small. Three items showed substantial agreement beyond chance (κ≥0.6); 2 items showed moderate agreement (κ=0.40 to 0.59); most items showed fair agreement (κ=0.20 to 0.39). The food items showing substantial agreement were hot or cold cereal, low-fat milk, and mutton or chile stew. Fried or scrambled eggs and deep-fried foods showed moderate agreement beyond chance. Previous development and validation of brief food selection instruments for children participating in health promotion programs has had limited success. In this study, instrument-related factors that apparently contributed to poor agreement between data from the YFC and 24-hour dietary recall were inclusion of categories of foods vs specific foods; food knowledge, preparation, and vocabulary; item length; and overreporting of attractive foods. Collecting and scoring the 24-hour recall data may also have contributed to poor agreement. Further development of brief instruments for evaluating changes in children's behavior in dietary intervention programs is necessary. Factors related to the YFC that need further development may be issues that are also important in the development of effective, brief dietary assessments for children as individual clients or patients.
KW - American indians
KW - children
KW - diet study techniques
KW - eggs
KW - ethnic groups
KW - food preferences
KW - foods
KW - health
KW - health promotion
KW - low fat milk
KW - milk
KW - neoplasms
KW - prevention
KW - students
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - diet preferences
KW - taste preferences
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001413999&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Status of nutrition labeling, health claims, and nutrient content claims for processed foods: 1997 food label and package survey.
AU - Brecher, S. J.
AU - Bender, M. M.
AU - Wilkening, V. L.
AU - McCabe, N. M.
AU - Anderson, E. M.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2000///
VL - 100
IS - 9
SP - 1057
EP - 1062
SN - 0002-8223
AD - Brecher, S. J.: Food and Drug Administration, Center for Food Safety and Applied Nutrition/Office of Nutritional Products, Labeling and Dietary, Supplements, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20001421562. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - The Food and Drug Administration (FDA) conducts studies of food labels as part of its ongoing monitoring of the nutritional status of the US population. In 1994 FDA nutrition labelling rules were implemented and in 1997 the Food Label and Package Survey characterized various aspects of the labelling of processed, packaged foods, including nutrition labelling, health claims, and nutrient content claims. For the survey, FDA selected a multistage, representative sample of food products from the SCAN-TRACK food sales database (AC Nielsen Co, Schaumburg, III). FDA identified 58 product groups and selected those product classes from the database that accounted for 80% of sales in each group. From each product class, FDA selected the 3 top-selling product brands and randomly selected follower brands. Based on label information from a final sample of 1267 food products, FDA determined the percentage of products sold that bear Nutrition Facts labels, health claims, and nutrient content claims. The purpose of this article was to present FDA findings regarding the status of food labels 3 years after implementation of the nutrition labelling rules. Nutrition-labelled products accounted for an estimated 96.5% of the annual sales of processed, packaged foods. An additional 3.4% of products sold were exempt from labelling regulations. Nutrient content claims and health claims appeared on an estimated 39% and 4%, respectively, of the products sold. Dietitians and other health care professionals can use this survey information to identify food types with specific label information and to assist the US consumer in making more varied and healthful food choices in the marketplace.
KW - consumers
KW - dietitians
KW - food processing
KW - foods
KW - labelling
KW - legislation
KW - nutrients
KW - nutrition
KW - nutritive value
KW - packaging
KW - processed products
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - nutritional value
KW - quality for nutrition
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Marketing and Distribution (EE700)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative determination of conjugated linoleic acid isomers in beef fat.
AU - Fritsche, J.
AU - Fritsche, S.
AU - Solomon, M. B.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Morehouse, K.
AU - Ku, Y.
JO - European Journal of Lipid Science and Technology
JF - European Journal of Lipid Science and Technology
Y1 - 2000///
VL - 102
IS - 11
SP - 667
EP - 672
CY - Weinheim; Germany
PB - Wiley-VCH Verlag GmbH
SN - 1438-7697
AD - Fritsche, J.: US Food and Drug Administration, Center of Food Safety and Applied Nutrition, Office of Food Labeling, Washington DC, USA.
N1 - Accession Number: 20003027064. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 61789-97-7, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition
N2 - The amounts of 14 conjugated linoleic acid (CLA) isomers (t12t14, t11t13, t10t12, t9t11, t8t10, t7t9, t6t8; 12, 14 c/t, t11c13, c11t13, t10c12, 9, 11 c/t, t8c10, t7c9-18:2) in 20 beef samples were determined by triple-column silver-ion HPLC (Ag+-HPLC). Quantitation was performed using an external CLA reference standard consisting of cis9, trans11-18:2, trans9, trans11-18:2 and cis9, cis11-18:2. Linearity was checked as being r>0.9999 between 0.02×10-3 to 2 mg/ml. The determination limit (5-fold signal/noise ratio) of the CLA reference was estimated to be 0.25, 0.50, 1.0 ng/injection for the cis/trans, trans and cis isomers, respectively. As expected, cis9, trans11-18:2 was the predominant isomer (1.95±0.54 mg/g fat) in beef, followed by trans7, cis9-18:2 (0.19±0.04 mg/g fat); cis, cis isomers were below the determination limit in most beef samples. Total CLA amounts determined by Ag+-HPLC were compared to total CLAs determined by gas chromatography (GC, 100 m CPSilTM 88 column). The amounts obtained by GC were generally higher than those determined by Ag+-HPLC due to co-eluting compounds.
KW - analytical methods
KW - animal fat
KW - beef
KW - composition
KW - conjugated linoleic acid
KW - foods
KW - isomers
KW - meat
KW - tallow
KW - analytical techniques
KW - beef fat
KW - Meat Produce (QQ030)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The determination of equivalent doses of standardized allergen vaccines.
AU - Slater, J. E.
AU - Pastor, R. W.
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2000///
VL - 105
IS - 3
SP - 468
EP - 474
SN - 0091-6749
AD - Slater, J. E.: Laboratory of Immunobiochemistry, Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike (HFM-422), Rockville, MD 20852, USA.
N1 - Accession Number: 20000507238. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This investigation combines assay variability, clinical limits, and lot-to-lot consistency, in assessing the relative potency (RP) limits for grass pollen (Ambrosia artemisiifolia Amb a1) and dust mite allergen (Dermatophagoides pteronyssinus Der p1) vaccines. Acceptable ranges of therapeutic and safety equivalence for standardized allergen vaccines are estimated from the available literature. Safety equivalence was further analysed within the context of a relatively simple question: what is the expected range of RPs when two successive samples are picked at random from a distribution. The consistency of lots of allergenic vaccines submitted to Center for Biologics Evaluation and Research for testing since 1995 were determined from an analysis of failure rates. Finally, the derived sample distributions were compared with the estimated clinical limits and current lot-release limits. The analysis showed that current lot-release limits for relative potency (0.65401.530) were well within the literature-based estimates of therapeutic, diagnostic, and safety equivalence ranges for the clinical use of allergen vaccines. The aggregate consistency of the submitted products was comparable with the precision of the assay that was used to assess the products. These results support the expanded release limits for verification of RP, provided the submitted lots of material remain at their present level consistency.
KW - allergens
KW - extracts
KW - house dust mites
KW - pollen
KW - potency
KW - safety
KW - vaccines
KW - Acari
KW - Ambrosia artemisiifolia
KW - Dermatophagoides pteronyssinus
KW - mites
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Ambrosia
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - house dust mite
KW - house-dust mites
KW - housedust mites
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The stability of house dust mite allergens in glycerinated extracts.
AU - Soldatova, L. N.
AU - Paupore, E. J.
AU - Burk, S. H.
AU - Pastor, R. W.
AU - Slater, J. E.
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2000///
VL - 105
IS - 3
SP - 482
EP - 488
SN - 0091-6749
AD - Soldatova, L. N.: Laboratory of Immunobiochemistry, Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike (HFM-422), Rockville, MD 20852, USA.
N1 - Accession Number: 20000507277. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The following studies were initiated to determine the relative potency and allergen content of mite extracts (Dermatophagoides farinae) stored at varying temperatures over a period of 12 months compared with lyophilized controls that were placed in solution a few hours before the assay. In addition, because protease activity is one likely mechanism for allergen degradation, the effect of protease inhibitors on the stability of relative potency and specific allergen content was investigated. Potency of the extracts as determined by ELISA was preserved at -20°C and 4°C, allergen specific-assays indicated loss of allergens. It is concluded that the competition ELISA is insensitive to decreases in the concentrations of individual allergens. There was no evidence that protease inhibitors contributed to the stability of the mite extracts.
KW - allergens
KW - degradation
KW - extracts
KW - house dust mites
KW - potency
KW - proteinases
KW - storage
KW - temperature
KW - Acari
KW - Dermatophagoides farinae
KW - mites
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - house-dust mites
KW - housedust mites
KW - proteases
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000507277&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cloning of the immunodominant 17-kDa antigen from Cryptosporidium parvum.
AU - Priest, J. W.
AU - Kwon, J. P.
AU - Arrowood, M. J.
AU - Lammie, P. J.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 2000///
VL - 106
IS - 2
SP - 261
EP - 271
SN - 0166-6851
AD - Priest, J. W.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Mail Stop F-13, Building 23, Room 1025, 4770 Buford Highway N.E., Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20000806852. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 308067-58-5. Subject Subsets: Protozoology
N2 - Infection with Cryptosporidium parvum causes a self-limiting diarrhoeal illness in immunocompetent individuals and is associated with the development of a serum IgG antibody response dominated by the 27-kDa and 17-kDa parasite surface antigens. Antibodies against these antigens may thus serve as useful markers for past infection with C. parvum and to this end a recombinant form of the 17-kDa antigen would be useful both in epidemiological studies and in studies of the role of the humoral response in immunity. The immunodominant 17-kDa surface antigen from sporozoites was partially purified and sequenced, and a 975-bp open reading frame that includes all of the 17-kDa antigen peptide sequences was cloned. Immunological identity between a recombinant form of the protein and the native 17-kDa antigen was demonstrated. It was concluded that the carboxy-terminal fragment of the cloned protein is the authentic 17-kDa antigen.
KW - antibodies
KW - antigens
KW - cryptosporidiosis
KW - disease markers
KW - human diseases
KW - IgG
KW - immune response
KW - molecular genetics
KW - nucleotide sequences
KW - open reading frames
KW - parasites
KW - recombinant antigens
KW - recombinant proteins
KW - sporozoites
KW - surface antigens
KW - Cryptosporidium parvum
KW - man
KW - protozoa
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - antigenicity
KW - biochemical genetics
KW - DNA sequences
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - ORFs
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neurologic function among termiticide applicators exposed to chlorpyrifos.
AU - Steenland, K.
AU - Dick, R. B.
AU - Howell, R. J.
AU - Chrislip, D. W.
AU - Hines, C. J.
AU - Reid, T. M.
AU - Lehman, E.
AU - Laber, P.
AU - Krieg, E. F., Jr.
AU - Knott, C.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2000///
VL - 108
IS - 4
SP - 293
EP - 300
SN - 0091-6765
AD - Steenland, K.: National Institute for Occupational Safety and Health, Cincinnati (NIOSH), R13, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20002015564. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 2921-88-2. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - We studied neurological function in 191 current and former termiticide applicators working during 1987-97 in North Carolina, USA, who had an average of 2.4 years applying chlorpyrifos and 2.5 years applying other pesticides, and we compared them to 189 nonexposed controls. The average urinary TCP (chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol) level for 65 recently exposed applicators was 629.5 µg/l compared to 4.5 µg/l for the general US population. The exposed group did not differ significantly from the nonexposed group for any test in the clinical examination. Few significant differences were found in nerve conduction velocity, arm/hand tremor, vibrotactile sensitivity, vision, smell, visual/motor skills, or neurobehavioral skills. The exposed group did not perform as well as the nonexposed group in pegboard turning tests and some postural sway tests. The exposed subjects also reported significantly more symptoms, including memory problems, emotional states, fatigue, and loss of muscle strength; our more quantitative tests may not have been adequate to detect these symptoms. Eight men who reported past chlorpyrifos poisoning had a pattern of low performance on a number of tests, which is consistent with prior reports of chronic effects of organophosphate poisoning. Overall, the lack of exposure effects on the clinical examination was reassuring. The findings for self-reported symptoms raise some concern, as does the finding of low performance for those reporting prior poisoning. Although this was a relatively large study based on a well-defined target population, the workers we studied may not be representative of all exposed workers, and caution should be exercised in generalizing our results.
KW - chlorpyrifos
KW - human diseases
KW - neurotoxicity
KW - organophosphorus compounds
KW - pesticides
KW - poisoning
KW - symptoms
KW - urine
KW - workers
KW - North Carolina
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - chlorpyrifos-ethyl
KW - organic phosphorus compounds
KW - organophosphates
KW - termiticide applicators
KW - toxicosis
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002015564&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silicosis and coal workers' pneumoconiosis.
AU - Castranova, V.
AU - Vallyathan, V.
A2 - Speizer, F. E.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2000///
VL - 108
IS - Supp 4
SP - 675
EP - 684
SN - 0091-6765
AD - Castranova, V.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS2015, Morgantown, W 26505, USA.
N1 - Accession Number: 20002016727. Publication Type: Journal Article. Language: English. Number of References: 130 ref. Registry Number: 7631-86-9.
N2 - Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the aetiology of CWP and silicosis: (a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; (b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; (c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; (d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms.
KW - aetiology
KW - cells
KW - characteristics
KW - coal workers
KW - cytokines
KW - cytotoxicity
KW - disease course
KW - epithelium
KW - exposure
KW - fibrosis
KW - growth factors
KW - human diseases
KW - leukocytes
KW - lipid peroxidation
KW - lungs
KW - macrophages
KW - occupational health
KW - phagocytes
KW - pneumoconioses
KW - respiratory diseases
KW - silica
KW - silicosis
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - causal agents
KW - disease progression
KW - epithelial cells
KW - etiology
KW - leucocytes
KW - lung diseases
KW - pneumoconiosis
KW - polymorphonuclear leukocytes
KW - white blood cells
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016727&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vibrio gastroenteritis in the US Gulf of Mexico region: the role of raw oysters.
AU - Altekruse, S. F.
AU - Bishop, R. D.
AU - Baldy, L. M.
AU - Thompson, S. G.
AU - Wilson, S. A.
AU - Ray, B. J.
AU - Griffin, P. M.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2000///
VL - 124
IS - 3
SP - 489
EP - 495
SN - 0950-2688
AD - Altekruse, S. F.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Atlanta, Georgia, USA.
N1 - Accession Number: 20002015452. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - We examined clinical and epidemiological features of 575 laboratory-confirmed cases of Vibrio gastroenteritis in Alabama, Florida, Louisiana, and Texas, USA during 1988-97 (the US Gulf of Mexico Regional Vibrio Surveillance System). Illnesses occurred year round, with peaks in spring and autumn. Illnesses lasted a median of 7 days and included fever in half of patients and bloody faeces in 25% of patients with relevant information. 72% of patients reported no underlying illnesses. In the week before onset, 236 (53%) of 445 patients for whom data were available ate raw oysters, generally at a restaurant or bar. Educational efforts should address the risk of Vibrio gastroenteritis for raw oyster consumers, including healthy individuals. Further studies should examine environmental conditions affecting Vibrio counts on seafood and processing technologies to enhance the safety of raw oysters.
KW - clinical aspects
KW - disease prevalence
KW - epidemiology
KW - foodborne diseases
KW - gastroenteritis
KW - human diseases
KW - oysters
KW - raw foods
KW - Alabama
KW - Florida
KW - Louisiana
KW - Texas
KW - USA
KW - man
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - Delta States of USA
KW - West South Central States of USA
KW - Great Plains States of USA
KW - Southern Plains States of USA
KW - Southwestern States of USA
KW - bacterium
KW - clinical picture
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA adduct formation by Fusarium culture extracts: lack of role of fusarin C.
AU - Bever, R. J., Jr.
AU - Couch, L. H.
AU - Sutherland, J. B.
AU - Williams, A. J.
AU - Beger, R. D.
AU - Churchwell, M. I.
AU - Doerge, D. R.
AU - Howard, P. C.
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2000///
VL - 128
IS - 2
SP - 141
EP - 157
CY - Shannon; Irish Republic
PB - Elsevier Scientific Publishers Ireland Ltd
SN - 0009-2797
AD - Bever, R. J., Jr.: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, US Food and Drug Administration, US Public Health Service, 3900 NCTR Road, Jefferson, AR 72079-9205, USA.
N1 - Accession Number: 20013133152. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Maize; Medical & Veterinary Mycology
N2 - Fusarium fungi have been shown to infect maize and other crops worldwide, and have a significant impact on human health through loss of crops or contamination of food with mycotoxins. Isolates of Fusarium fungi from an area of South Africa with high incidence of oesophageal cancer have been shown to induce oesophageal and liver cancer in rats. Several isolates of Fusarium fungi were grown on maize to determine if genotoxic products were produced. We report the incubation of methanol extracts of F. verticillioides cultures with DNA in the presence of rat liver fractions (S9) resulted in the formation of a unique DNA adduct that was detected by 32P-postlabelling. Fusarin C was purified from cultures of F. verticillioides RRC 415, and was not responsible for the formation of the DNA adduct. Treatment of the methanolic extracts with ultraviolet B radiation reduced the fusarin C content in the extract; however, this had no effect on the formation of the DNA adduct following incubation of the extract with DNA and S9. The unique DNA adduct was formed following the incubation of several F. verticillioides isolates from the USA and South Africa, while extracts of cultures of F. graminearium [Gibberella zeae] and F. sacchari isolates formed very little of the DNA adduct when incubated with DNA and S9. These data suggest that neither fusarin C nor any of its metabolites are responsible for formation of the DNA adduct, and that an unidentified compound is present in F. verticillioides cultures that forms a DNA adduct, and may be important in the aetiology of human oesophageal cancer.
KW - disease models
KW - fusarins
KW - liver
KW - maize
KW - neoplasms
KW - oesophageal cancer
KW - oesophagus
KW - Fusarium
KW - Fusarium sacchari
KW - Gibberella fujikuroi
KW - Gibberella zeae
KW - Hypocreaceae
KW - Zea mays
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Gibberella
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Fusarium
KW - cancers
KW - corn
KW - esophageal cancer
KW - esophagus
KW - fungus
KW - Fusarium verticillioides
KW - Gibberella moniliformis
KW - Hyphomycetes
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013133152&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats.
AU - Chang, H. C.
AU - Churchwell, M. I.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Doerge, D. R.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2000///
VL - 130
IS - 8S
SP - 1963
EP - 1970
SN - 0022-3166
AD - Chang, H. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20001422077. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 446-72-0. Subject Subsets: Dairy Science; Human Nutrition; Soyabeans
N2 - Genistein, the principal soy isoflavone, was administered in the diet to male and female Sprague-Dawley rats as part of a multigeneration study of potential endocrine modulation. The rats were exposed to genistein in utero, through maternal milk, and as adults through postnatal d 140 via essentially isoflavone-free feed (~0.5 µg/g) fortified at 5, 100 and 500 µg/g with genistein aglycone. Analytical methods based on liquid chromatography, mass spectrometry and the use of deuterated genistein were developed and validated for use in measuring genistein in serum and tissues. Pharmacokinetic analysis of serum genistein showed a significant difference (P<0.001) in the elimination half-life and area under the concentration-time curve between male [2.97±0.14 h and 22.3±1.2 µmol/(L . h), respectively] and female rats [4.26±0.29 h and 45.6±3.1 µmol/(L . h), respectively, ±SEM]. Endocrine-responsive tissues including brain, liver, mammary, ovary, prostate, testis, thyroid and uterus showed significant dose-dependent increases in total genistein concentration. Female liver contained the highest amount of genistein (7.3 pmol/mg tissue) and male whole brain contained the least (0.04 pmol/mg). The physiologically active aglycone form was present in tissues at fractions up to 100%, and the concentration was always greater than that observed in serum in which conjugated forms predominated (95-99%). These results for measured amounts of genistein, present as aglycone and conjugates, in putative target tissues provide a link with other studies in which blood concentrations and physiologic effects of genistein are measured.
KW - analytical methods
KW - brain
KW - diet
KW - distribution
KW - genistein
KW - intake
KW - liver
KW - mass spectrometry
KW - milk
KW - ovaries
KW - prostate
KW - testes
KW - thyroid gland
KW - tissues
KW - uterus
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - biochanin A
KW - cerebrum
KW - testicles
KW - thyroid
KW - Animal Models of Human Nutrition (VV140)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interactive effects of methyl-deficiency and dietary restrictionon liver cell proliferation and telomerase activity in Fischer 344 rats pretreated with aflatoxin B1.
AU - Chou, M. W.
AU - Mikhailova, M. V.
AU - Nichols, J.
AU - Poirier, L. A.
AU - Warbritton, A.
AU - Beland, F. A.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2000///
VL - 152
IS - 1
SP - 53
EP - 61
CY - Shannon; Irish Republic
PB - Elsevier Scientific Publishers Ireland Ltd
SN - 0304-3835
AD - Chou, M. W.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013172169. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 50812-37-8. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - The effects of methyl-deficiency and dietary restriction (DR) on hepatic cell proliferation and telomerase activity was studied in male Fischer 344 rats pretreated with aflatoxin B1 (AFB1). Five-week-old rats were gavaged 5 days per week for 3 weeks with AFB1 (25 µg/rat per day) or solvent (100 µl 75% dimethylsulfoxide). Rats were then divided into four groups. Two groups were fed a methyl-sufficient (MS) diet either ab libitum (AL) or with DR. The other two groups were fed a methyl-deficient (MD) diet either AL or with DR. At 15, 20, and 32 weeks of age, hepatic cell proliferation, telomerase activity, and the number of glutathione S-transferase-P positive (GST-P+) foci were determined. DR reduced hepatic cell proliferation, while the MD diet and AFB1 pretreatment increased cell proliferation. Telomerase activity was decreased by DR and increased by the MD diet and AFB1 pretreatment. The same trend was observed with GST-P+ foci: in AFB1-pretreated rats, methyl deficiency increased the number of foci, while DR decreased the number. These results are consistent with a role of telomerase in hepatocarcinogenesis.
KW - aflatoxins
KW - animal models
KW - carcinogenesis
KW - diets
KW - enzyme activity
KW - glutathione transferase
KW - laboratory animals
KW - liver cells
KW - mycotoxins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungal toxins
KW - hepatocytes
KW - ligandin
KW - telomerase
KW - Animal Models of Human Nutrition (VV140)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013172169&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki syndrome hospitalizations among children in Hawaii and Connecticut.
AU - Holman, R. C.
AU - Shahriari, A.
AU - Effler, P. V.
AU - Belay, E. D.
AU - Schonberger, L. B.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2000///
VL - 154
IS - 8
SP - 804
EP - 808
AD - Holman, R. C.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA, USA.
N1 - Accession Number: 20002016963. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - A study was performed to estimate the incidence and describe recent trends of Kawasaki syndrome (KS) in 2 different areas of the USA. A retrospective analysis was made of Hawaii and Connecticut State KS hospital discharge records for children younger than 5 years. In Hawaii, 175 KS hospitalizations for children younger than 5 years were reported during 1994-97; the annual hospitalization rate per 100 000 children was 47.7. The rate for Hawaiian children younger than 1 year (83.2) was greater than that for 1- to 4-year-old children (39.0), and most hospitalizations occurred prior to age 2 years (median age, 17 months). In Connecticut, 171 KS hospitalizations for children younger than 5 years were reported during 1993-96; the annual hospitalization rate per 100 000 children was 18.8, and the median age at hospitalization was 28 months. For both states, most hospitalizations were for boys. Although no clear seasonality was apparent, monthly peaks occurred in some of the years from December to March. It is concluded that Kawasaki syndrome seems to remain an endemic disease in the USA. A high KS annual hospitalization rate was seen in Hawaii, especially in children younger than 1 year, whereas in Connecticut, the KS rate was more consistent with those previously reported in the continental USA.
KW - boys
KW - children
KW - epidemiology
KW - human diseases
KW - incidence
KW - Kawasaki disease
KW - seasonality
KW - trends
KW - Connecticut
KW - Hawaii
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific States of USA
KW - Western States of USA
KW - Polynesia
KW - Oceania
KW - Pacific Islands
KW - mucocutaneous lymph node syndrome
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002016963&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for chlamydia in adolescents and young women.
AU - Mangione-Smith, R.
AU - McGlynn, E. A.
AU - Hiatt, L.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2000///
VL - 154
IS - 11
SP - 1108
EP - 1113
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Mangione-Smith, R.: Agency for Healthcare Research and Quality, Rockville, Md, Family Planning Council, Atlanta, Ga, USA.
N1 - Accession Number: 20003023040. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - A study was conducted to measure the proportion of sexually active females aged 15 to 25 years who received a screening test for Chlamydia trachomatis infection during the previous year. Administrative data were used to identify females in the target age range who were likely to be sexually active. Medical record data were reviewed for a sample to determine whether the administrative algorithm was acceptable. Laboratory claims data and medical record data were used to identify females who had had a screening test for chlamydia. The study comprised 19,214 sexually active females aged 15 to 25 years continuously enrolled for calendar year 1997 in 1 of 4 major US health plans who had a visit to their health care provider during that year. Sexual activity was determined using an algorithm designed for use with administrative data. The main outcome measures were rates of chlamydia screening among sexually active females aged 15 to 25 years. The proportion of females aged 15 to 25 years identified as sexually active by the administrative data algorithm in the 4 health plans was similar (43%-54%; P=.79). However, substantial variation was found in rates of chlamydia screening for eligible females in these 4 health plans (2%-42%; P<.001). Plans varied considerably in the types of visits (eg, sexually transmitted disease screening or pregnancy) that determined eligibility for the measure. A measure of health plan performance on screening for chlamydia in young females using administrative data is feasible and provides useful results despite some flaws in estimation. There is room for improvement in rates of chlamydia screening in sexually active females aged 15 to 25 years.
KW - adolescents
KW - children
KW - girls
KW - human diseases
KW - screening
KW - sexually transmitted diseases
KW - women
KW - USA
KW - Chlamydia trachomatis
KW - man
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - screening tests
KW - STDs
KW - teenagers
KW - United States of America
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003023040&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect.
AU - Chang, H. C.
AU - Doerge, D. R.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2000///
VL - 168
IS - 3
SP - 244
EP - 252
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Chang, H. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013141668. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 446-72-0, 903-99-0. Subject Subsets: Pig Science; Human Nutrition; Soyabeans
N2 - 48 Sprague-Dawley rats were exposed to genistein aglycone in soy-free feed fortified at 0, 5, 100, and 500 ppm starting in utero through 20 weeks. The total genistein content in rat serum was 8 µM. In male and female rats, significant dose-dependent increases of genistein in thyroid tissue up to pmol/mg were found and the microsomal thyroid peroxidase (TPO) activity was found to be reduced by up to 80% in a dose-dependent manner. In male and female rats consuming a standard soy-based rodent diet, the TPO activity was approx. 50% lower than the rats consuming a soy-free diet. Suicide inactivation of rat, porcine, and human TPO was observed in vitro at concentrations of genistein aglycone comparable to those measured in rat thyroids. Thyroid hormone levels (T3, T4, TSH) in serum, thyroid weights, and histopathology showed no differences between treated and untreated gorups.
KW - animal models
KW - enzyme activity
KW - females
KW - genistein
KW - males
KW - peroxidase
KW - thyroid gland
KW - thyroid hormones
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - thyroid
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013141668&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin.
AU - Hur, H. G.
AU - Lay, J. O., Jr.
AU - Beger, R. D.
AU - Freeman, J. P.
AU - Rafii, F.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2000///
VL - 174
IS - 6
SP - 422
EP - 428
CY - Berlin; Germany
PB - Springer-Verlag
SN - 0302-8933
AD - Hur, H. G.: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20013159357. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - Faecal bacteria from a healthy individual were screened for the specific bacteria involved in the metabolism of dietary isoflavonoids. Two strains of bacteria capable of producing primary and secondary metabolites from the natural isoflavone glycosides daidzin and genistin were detected. The metabolites were identified by comparison of their HPLC/mass, 1H NMR and UV spectra with those of standard and synthetic compounds. Both Escherichia coli HGH21 and the gram-positive strain HGH6 converted daidzin and genistin to the their respective aglycones daidzein and genistein. Under anoxic conditions, strain HGH6 further metabolized the isoflavones daidzein and genistein to dihydrodaidzein and dihydrogenistein, respectively. The reduction of a double bond between C-2 and C-3 to a single bond was isoflavonoid-specific by strain HGH6, which did not reduce a similar bond in the flavonoids apigenin and chrysin. Strain HGH6 did not further metabolize dihydrodaidzein and dihydrogenistein. This is the first study in which specific colonic bacteria that are involved in the metabolism of daidzin and genistin have been detected.
KW - glycosides
KW - isoflavones
KW - isoflavonoids
KW - metabolism
KW - plant oestrogens
KW - secondary metabolites
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - E. coli
KW - heterosides
KW - phytoestrogens
KW - plant estrogens
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013159357&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of interferon-γ signaling by Leishmania donovani.
AU - Ray, M.
AU - Gam, A. A.
AU - Boykins, R. A.
AU - Kenney, R. T.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 181
IS - 3
SP - 1121
EP - 1128
SN - 0022-1899
AD - Ray, M.: Laboratory of Parasitic Biology and Biochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.
N1 - Accession Number: 20000808101. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9008-11-1, 60-18-4. Subject Subsets: Protozoology
N2 - The IFN-γ signal transduction pathway was analysed in Leishmania donovani-infected phorbol-differentiated U937 human promonocytic cells. IFN-γ stimulation induced marked phosphorylation of its own receptor (IFN-γR)-α chain. Phosphorylation of the receptor subunit was significantly inhibited after 24 h of infection with the parasite, apparently because of decreased amounts of the receptor subunit. Formation of the IFN-γR complex, as assessed by tyrosine phosphorylation and association of Jak2, was strongly inhibited in cells infected for 24 h. Inhibition of the IFN-γR complex formation correlated with inhibition of STAT1α binding to the IFN-γ response region. Pretreatment with purified parasite lipophosphoglycan before IFN-γ stimulation had no effect on tyrosine phosphorylation. It is concluded that inhibition of tyrosine phosphorylation of the IFN-γR-α chain and subsequent signal transduction are most likely due to the decreased amount of IFN-γR-α protein after infection.
KW - immunosuppression
KW - interferon
KW - lipophosphoglycans
KW - macrophages
KW - parasites
KW - phosphorylation
KW - signal transduction
KW - tyrosine
KW - Leishmania donovani
KW - protozoa
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - down regulation
KW - tyrosine phosphorylation
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000808101&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nucleotide sequences that distinguish Oka vaccine from parental Oka and other varicella-zoster virus isolates.
AU - Argaw, T.
AU - Cohen, J. I.
AU - Klutch, M.
AU - Lekstrom, K.
AU - Yoshikawa, T.
AU - Asano, Y.
AU - Krause, P. R.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 181
IS - 3
SP - 1153
EP - 1157
SN - 0022-1899
AD - Argaw, T.: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland, USA.
N1 - Accession Number: 20002011787. Publication Type: Journal Article. Language: English. Number of References: 18 ref.
N2 - The sequences of ~34 kb from the 3′ end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.
KW - clinical aspects
KW - human diseases
KW - open reading frames
KW - strains
KW - vaccines
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clinical picture
KW - ORFs
KW - vaccine strains
KW - varicella-zoster virus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002011787&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A typing system for Neisseria gonorrhoeae based on biotinylated oligonucleotide probes to PIB gene variable regions.
AU - Thompson, D. K.
AU - Deal, C. D.
AU - Ison, C. A.
AU - Zenilman, J. M.
AU - Bash, M. C.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 181
IS - 5
SP - 1652
EP - 1660
SN - 0022-1899
AD - Thompson, D. K.: Division of Bacterial, Parasitic and Allergenic Products, HFM-428, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20002014668. Publication Type: Journal Article. Language: English. Number of References: 34 ref.
N2 - The porin proteins PIA and PIB of Neisseria gonorrhoeae are serotyping antigens for the serovar classification system and leading candidates for gonococcal vaccine development. Although serotyping has been a useful tool, this method can be insensitive to critical sequence changes in the por gene, including those in surface-exposed variable regions (VRs). A sensitive and specific typing system for N. gonorrhoeae has been developed that uses biotin-labelled oligonucleotide probes with chemiluminescence detection to type PIB gene VRs. The PIB VR types of geographically and temporally diverse gonococcal strains and sexual contact isolates were determined. por VR typing discriminated between most unrelated isolates and provided information about individual VR type that was not apparent from serovar designations. PIB VR typing avoids limited monoclonal antibody availability, interlaboratory variation, and the requirement for culture-based surveillance associated with gonococcal serotyping, and provides useful information about the molecular epidemiology of individual por gene VRs.
KW - genes
KW - human diseases
KW - oligonucleotides
KW - probes
KW - serotypes
KW - techniques
KW - man
KW - Neisseria gonorrhoeae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002014668&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Direct polymerase chain reaction for detection of toxigenic Corynebacterium diphtheriae strains from the Republic of Georgia after prolonged storage.
AU - Kobaidze, K.
AU - Popovic, T.
AU - Nakao, H.
AU - Quick, L.
A2 - Wharton, M.
A2 - Dittmann, S.
A2 - Strebel, P. M.
A2 - Mortimer, E. A., Jr.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 181
IS - Sup.1
SP - S152
EP - S155
SN - 0022-1899
AD - Kobaidze, K.: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20002012553. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - A total of 226 paired nose and throat swab specimens collected from 113 clinical diphtheria cases from the Republic of Georgia between October 1995 and March 1996, were analysed by direct polymerase chain reaction targeting both A and B subunits of the diphtheria toxin gene, tox. Even after prolonged transport and extensive storage (7-14 months) of the clinical specimens in silica gel packages, direct polymerase chain reaction detected the diphtheria tox gene in 54% of the specimens. Specimens obtained by throat swab were three times more likely than those obtained by nose swab to be positive for Corynebacterium diphtheriae.
KW - detection
KW - diagnosis
KW - diphtheria
KW - human diseases
KW - nose
KW - polymerase chain reaction
KW - specimen handling
KW - storage
KW - throat
KW - Republic of Georgia
KW - Corynebacterium diphtheriae
KW - man
KW - Corynebacterium
KW - Corynebacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - West Asia
KW - Asia
KW - bacterium
KW - PCR
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002012553&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of CD4+ T cell function in vivo in HIV-infected patients as measured by bacteriophage phiX174 immunization.
AU - Fogelman, I.
AU - Davey, V.
AU - Ochs, H. D.
AU - Elashoff, M.
AU - Feinberg, M. B.
AU - Mican, J.
AU - Siegel, J. P.
AU - Sneller, M.
AU - Lane, H. C.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 182
IS - 2
SP - 435
EP - 441
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Fogelman, I.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20003000471. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 308067-58-5, 63231-63-0. Subject Subsets: Public Health
N2 - Bacteriophage phiX174 immunization was used to measure CD4+ T cell function in vivo in human immunodeficiency virus (HIV)-infected patients across all disease stages. Function was evaluated by measuring the ability of T cells to provide help to B cells in antibody production, amplification, and isotype switching. The study was conducted by the Food and Drug Administration and the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, USA [date not given]. A total of 33 patients and 10 controls received 3 bacteriophage phiX174 immunizations 6 weeks apart. The patients' responses regarding bacteriophage-specific total antibody titres and IgG titres were quantitatively and qualitatively inferior to the controls' responses. Overall, 7 of 33 patients had normal T cell function. Baseline CD4 counts provided the strongest correlation with total antibody and IgG titres. HIV RNA had a weaker association with responses but had some predictive power among patients with a CD4 count >200 cells/µL. Bacteriophage phiX174 immunization seems to be a useful tool for measuring immune function in vivo, which suggests that most HIV-infected patients may have abnormal CD4+ T cell function despite adequate antiretroviral treatment.
KW - antibodies
KW - bacteriophages
KW - CD4+ lymphocytes
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - IgG
KW - immune response
KW - immunization
KW - RNA
KW - T lymphocytes
KW - vaccination
KW - Maryland
KW - USA
KW - man
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - CD4+ cells
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - phages
KW - ribonucleic acid
KW - T cells
KW - T4 lymphocytes
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003000471&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunity to placental malaria. II. Placental antigen-specific cytokine responses are impaired in human immunodeficiency virus-infected women.
AU - Moore, J. M.
AU - Ayisi, J.
AU - Nahlen, B. L.
AU - Misore, A.
AU - Lal, A. A.
AU - Udhayakumar, V.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2000///
VL - 182
IS - 3
SP - 960
EP - 964
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Moore, J. M.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20003003387. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9008-11-1, 130068-27-8, 207137-56-2, 308079-78-9. Subject Subsets: Protozoology; Tropical Diseases
N2 - An association was demonstrated recently between elevated in vitro production of interferon (IFN)-γ by intervillous blood mononuclear cells (IVBMCs) and protection against placental malaria (PM). Because human immunodeficiency virus (HIV)-infected pregnant women from western Kenya have increased susceptibility to PM, loss of the IFN-γ response in these women may impair their ability to control PM. Measurement of cytokines in culture supernatants by ELISA revealed that IFN-γ responses by HIV-positive IVBMCs were impaired, especially after malarial antigen stimulation. Interleukin (IL)-4 and IL-10 responses also were reduced in HIV-positive persons, the latter more so in HIV-positive, PM-positive persons. In contrast, tumour necrosis factor-α production generally was enhanced in PM-positive and HIV-positive persons. Overall, cytokine production was reduced in HIV-positive persons with CD4 T cell counts <500/µl, particularly in response to malarial antigen. Thus, HIV-mediated cytokine dysregulation and impairment of the protective IFN-γ response may contribute to the increased susceptibility of HIV-positive pregnant women to malaria.
KW - CD4+ lymphocytes
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - interferon
KW - interleukin 10
KW - interleukin 4
KW - malaria
KW - pregnancy
KW - tumour necrosis factor
KW - women
KW - Kenya
KW - man
KW - Plasmodium falciparum
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - cachectin
KW - cachexin
KW - CD4+ cells
KW - gestation
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003003387&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr(VI)-induced DNA damage and Cr(IV)- or TPA-stimulated NF-κB activation.
AU - Shi XiangLin
AU - Ye JianPing
AU - Leonard, S. S.
AU - Ding Min
AU - Vallyathan, V.
AU - Castranova, V.
AU - Rojanasakul, Y.
AU - Dong Zigang
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
Y1 - 2000///
VL - 206
IS - 1/2
SP - 125
EP - 132
SN - 0300-8177
AD - Shi XiangLin: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20001417520. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Electron spin resonance (ESR) spin trapping was utilized to investigate the scavenging effects on hydroxyl radicals (OH) and superoxide radicals (O2-) by (-)-epigallocatechin-3-gallate (EGCG), one of the major anticancer compounds in tea. The spin trap used was 5,5-dimethyl-pyrroline N-oxide (DMPO). The Fenton reaction (Fe2+ + H2O2->Fe3+ + OH + OH-) was used as a source of OH radicals. EGCG efficiently scavenges OH radicals with reaction rate of 4.62×1011 M-1sec -1, which is an order of magnitude higher than several well recognized antioxidants, such as ascorbate, glutathione and cysteine. It also scavenges O2- radicals as demonstrated by using xanthine and xanthine oxidase system as a source of O2- radicals. Through its antioxidant properties, EGCG exhibited a protective effect against DNA damage induced by Cr(VI). EGCG also inhibited activation of nuclear transcription factor NF-κB induced by Cr(IV) and 12-o-tetradecanoylphorbol-13-acetate (TPA). The present studies provide a mechanistic basis for the reported anticarcinogenic properties of EGCG and related tea products.
KW - activity
KW - antineoplastic agents
KW - antioxidants
KW - carcinogenesis
KW - DNA
KW - flavanols
KW - free radicals
KW - inhibition
KW - polyphenols
KW - tea
KW - Camellia sinensis
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - cytotoxic agents
KW - deoxyribonucleic acid
KW - dna damage
KW - epigallocatechin gallate
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001417520&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Decision-based evaluation of recommendations for preexposure rabies vaccination.
AU - Murray, K. O.
AU - Arguin, P. M.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2000///
VL - 216
IS - 2
SP - 188
EP - 191
SN - 0003-1488
AD - Murray, K. O.: Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US, Department of Health and Human Services, 1600 Clifton Rd, Atlanta, GA 30333, USA.
N1 - Accession Number: 20002209119. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Veterinary Science
KW - adverse effects
KW - disease control
KW - disease prevention
KW - immunization
KW - rabies
KW - vaccination
KW - rabies virus
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - adverse reactions
KW - immune sensitization
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002209119&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological terrorism and veterinary medicine in the United States.
AU - Ashford, D. A.
AU - Gomez, T. M.
AU - Noah, D. L.
AU - Scott, D. P.
AU - Franz, D. R.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2000///
VL - 217
IS - 5
SP - 664
EP - 667
CY - Schaumburg; USA
PB - American Veterinary Medical Association
SN - 0003-1488
AD - Ashford, D. A.: United States Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
N1 - Accession Number: 20003000399. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health; Veterinary Science
KW - animal diseases
KW - biological warfare
KW - epidemiology
KW - human diseases
KW - surveillance
KW - terrorism
KW - veterinary medicine
KW - war
KW - USA
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Conflict (UU495) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breeds of dogs involved in fatal human attacks in the United States between 1979 and 1998.
AU - Sacks, J. J.
AU - Sinclair, L.
AU - Gilchrist, J.
AU - Golab, G. C.
AU - Lockwood, R.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2000///
VL - 217
IS - 6
SP - 836
EP - 840
CY - Schaumburg; USA
PB - American Veterinary Medical Association
SN - 0003-1488
AD - Sacks, J. J.: Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, US Department of Health and Human Services, US Public Health Service, Centers for Disease Control and Prevention, 4770 Buford Hwy NE (MS K-63), Atlanta, GA 30341, USA.
N1 - Accession Number: 20003004265. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health; Veterinary Science
KW - bites
KW - dog breeds
KW - mortality
KW - trauma
KW - USA
KW - dogs
KW - man
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - traumas
KW - United States of America
KW - Pets and Companion Animals (LL070)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003004265&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ten great veterinary public health/preventive medicine achievements in the United States, 1901 to 2000.
AU - Noah, D. L.
AU - Grayson, J. K.
AU - Caudle, L. C., III
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2000///
VL - 217
IS - 12
SP - 1834
EP - 1836
CY - Schaumburg; USA
PB - American Veterinary Medical Association
SN - 0003-1488
AD - Noah, D. L.: Office of the Surgeon General, United States Air Force, 110 Luke Avenue, Bolling AFB, DC 20332-7050, Noah, USA.
N1 - Accession Number: 20013008075. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Veterinary Science
KW - disease control
KW - disease prevention
KW - food hygiene
KW - public health
KW - veterinary medicine
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Professions: Practice and Service (CC700)
KW - Animal Science (General) (LL000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Postlicensure safety surveillance for varicella vaccine.
AU - Wise, R. P.
AU - Salive, M. E.
AU - Braun, M. M.
AU - Mootrey, G. T.
AU - Seward, J. F.
AU - Rider, L. G.
AU - Krause, P. R.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2000///
VL - 284
IS - 10
SP - 1271
EP - 1279
SN - 0098-7484
AD - Wise, R. P.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research HFM-225, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20002017829. Publication Type: Journal Article. Language: English. Number of References: 68 ref.
N2 - Since its licensure in 1995, the extensive use of varicella vaccine and close surveillance of the associated anecdotal reports of suspected adverse effects provide the opportunity to detect potential risks not observed before licensure because of the relatively small sample size and other limitations of clinical trials. A study was conducted to detect potential hazards, including rare events, associated with varicella vaccine, and to assess case reports for clinical and epidemiological implications. Postlicensure case-series study of suspected vaccine adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) was conducted from March 17, 1995 through July 25, 1998. Numbers of reported adverse events, proportions, and reporting rates (reports per 100 000 doses distributed) were determined. VAERS received 6574 case reports of adverse events in recipients of varicella vaccine, a rate of 67.5 reports per 100 000 doses sold. Approximately 4% of reports described serious adverse events, including 14 deaths. The most frequently reported adverse events were rashes, possible vaccine failures, and injection site reactions. Misinterpretation of varicella serology after vaccination appeared to account for 17% of reports of possible vaccine failures. Among 251 patients with herpes zoster, 14 had the vaccine strain of varicella zoster virus (VZV), while 12 had the wild-type virus. None of 30 anaphylaxis cases was fatal. An immunodeficient patient with pneumonia had the vaccine strain of VZV in a lung biopsy. Pregnant women occasionally received varicella vaccine through confusion with varicella zoster immunoglobulin. Although the role of varicella vaccine remained unproven in most serious adverse event reports, there were a few positive rechallenge reports and consistency of many cases with syndromes recognized as complications of natural varicella. It is concluded that most of the reported adverse events associated with varicella vaccine are minor, and serious risks appear to be rare. We could not confirm a vaccine aetiology for most of the reported serious events; several will require further study to clarify whether varicella vaccine plays a role. Education is needed to ensure appropriate use of varicella serological assays and to eliminate confusion between varicella vaccine and varicella zoster immunoglobulin.
KW - adverse effects
KW - anaphylaxis
KW - epidemiological surveys
KW - human diseases
KW - immunization
KW - immunological deficiency
KW - opportunistic infections
KW - pneumonia
KW - pregnancy
KW - surveillance
KW - vaccination
KW - vaccines
KW - varicella
KW - women
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - anaphylactic reactions
KW - anaphylactic shock
KW - chicken pox
KW - gestation
KW - immune deficiency
KW - immune sensitization
KW - immunodeficiency
KW - varicella-zoster virus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002017829&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Does further clean-up reduce the matrix enhancement effect in gas chromatographic analysis of pesticide residues in food?
AU - Schenck, F. J.
AU - Lehotay, S. J.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2000///
VL - 868
IS - 1
SP - 51
EP - 61
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Schenck, F. J.: Food and Drug Administration, Baltimore District Laboratory, 900 Madison Ave., Baltimore, MD 21201, USA.
N1 - Accession Number: 20023041452. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 2921-88-2, 121-75-5. Subject Subsets: Postharvest Research; Wheat, Barley & Triticale Abstracts; Horticultural Science; Agricultural Entomology
N2 - Sample extracts of apples, peas, green beans, oranges, raspberries, clementines, carrots, and wheat obtained using the Food and Drug Administration (acetone extraction) and Canadian Pest Management Regulatory Agency (acetonitrile extraction) multiresidue methods for pesticides were subjected to clean-up using different solid-phase extraction (SPE) cartridges in an attempt to reduce or eliminate the matrix enhancement effect. The matrix enhancement effect is related to the blocking of active sites on the injector liner by matrix components, thereby increasing the signal in the presence of matrix versus standards in solvent in which the pesticides themselves interact with the active sites. Graphitized carbon black (GCB) was often used in combination with various anion-exchange SPE cartridges. The extracts were then spiked with organophosphorus insecticides. These process standards were then compared to standards in acetone of the same concentration using gas chromatography with flame photometric detection or ion trap mass spectrometric detection. Sample matrix enhancement varied from little to no effect for some pesticides (e.g. chlorpyrifos and malathion) to >200% in the case of certain susceptible pesticides. The GCB removed colour components but showed little effect in reducing matrix enhancement by itself. The anion-exchange cartridges, combined or not combined with GCB, substantially reduced the matrix enhancement effect but did not eliminate it.
KW - analysis
KW - apples
KW - carrots
KW - chlorpyrifos
KW - clementines
KW - detection
KW - food
KW - GC-MS
KW - insecticides
KW - malathion
KW - oranges
KW - peas
KW - plant extracts
KW - raspberries
KW - wheat
KW - Citrus
KW - Citrus clementina
KW - Citrus sinensis
KW - Daucus carota
KW - Malus
KW - Malus pumila
KW - Phaseolus vulgaris
KW - Pisum sativum
KW - Rubus
KW - Rubus idaeus
KW - Triticum
KW - Triticum aestivum
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Citrus
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - Rosaceae
KW - Rosales
KW - Malus
KW - Phaseolus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Pisum
KW - Rubus
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - Triticum
KW - Araliales
KW - chlorpyrifos-ethyl
KW - clementine mandarins
KW - gas chromatography-mass spectrometry
KW - green bean
KW - pea
KW - Rutales
KW - snap bean
KW - Horticultural Crops (FF003) (New March 2000)
KW - Field Crops (FF005) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023041452&site=ehost-live&scope=site
UR - email: slehotay@arserrc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation.
AU - Liu, F. F.
AU - Ang, C. Y. W.
AU - Heinze, T. M.
AU - Rankin, J. D.
AU - Beger, R. D.
AU - Freeman, J. P.
AU - Lay, J. O., Jr.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2000///
VL - 888
IS - 1/2
SP - 85
EP - 92
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Liu, F. F.: US Food and Drug Administration, National Center for Toxicological Research, Division of Chemistry, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023054180. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science; Ornamnental Horticulture
N2 - A RP-HPLC method with photodiode array detection and LC-electrospray ionization (ESI) MS confirmation was established for the determination of major active components in St. John's Wort (Hypericum perforatum) dietary supplement capsules. The samples alternatively were extracted with ethanol-acetone (2:3) using a 55°C water-bath shaker or an ambient temperature ultrasonic bath. Extracts were separated by RP-C18 chromatography using a 95-min water-methanol-acetonitrile-trifluoroacetic acid gradient. The major components were identified by photodiode array detection and then confirmed by LC-ESI-MS. The quantification of components was performed using an internal standard (luteolin). This method may serve as a valuable tool for the quality evaluation of St. John's Wort dietary supplement products.
KW - chemical composition
KW - drugs
KW - food supplements
KW - HPLC
KW - mass spectrometry
KW - medicinal plants
KW - methodology
KW - Hypericum perforatum
KW - Hypericum
KW - Clusiaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - drug plants
KW - high performance liquid chromatography
KW - medicinal herbs
KW - medicines
KW - methods
KW - officinal plants
KW - pharmaceuticals
KW - St. John's wort
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023054180&site=ehost-live&scope=site
UR - email: cang@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Guidelines for mycotoxin tolerances in different countries.
AU - Pohland, A. E.
JO - Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University
JF - Bulletin of the Institute for Comprehensive Agricultural Sciences, Kinki University
Y1 - 2000///
IS - 8
SP - 47
EP - 53
SN - 0919-3022
AD - Pohland, A. E.: Joint Institute for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St., SW Washinton DC 20204, USA.
N1 - Accession Number: 20001203679. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - This paper summarizes the effort made, internationally, to control exposure to mycotoxins, with emphasis on the approach taken in the USA. A review of these efforts reveals clearly the differing approaches taken by various counties in regulating mycotoxins. In general, for economic reasons, exporting countries tend to set higher regulatory levels than importing counties, with the European countries being most restrictive. In most cases, a scientific rationale for setting a particular level is not apparent. Setting a regulatory level is of value only if enforcement is contemplated. Enforcement requires the development of defensible sampling plans, as well as access to validated analytical methods and certified reference materials. In recent years there has been a clear trend toward harmonization of regulatory levels and methods, as well as certification of laboratories and analysts engaged in the enforcement of such levels.
KW - analytical methods
KW - contamination
KW - control
KW - foods
KW - guidelines
KW - health
KW - laboratories
KW - mycotoxins
KW - reviews
KW - sampling
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - fungal toxins
KW - recommendations
KW - sampling techniques
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20001203679&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Concise International chemical assessment document 24: crystalline silica, quartz.
AU - Rice, F.
T2 - Concise International Chemical Assessment Document, International Programme on Chemical Safety
JO - Concise International Chemical Assessment Document, International Programme on Chemical Safety
JF - Concise International Chemical Assessment Document, International Programme on Chemical Safety
Y1 - 2000///
IS - 24
CY - Geneva; Switzerland
PB - World Health Organization
SN - 9241530243
AD - Rice, F.: National Institute of Occupational Safety and Health, Cincinnati, OH, USA.
N1 - Accession Number: 20013025086. Publication Type: Bulletin. Language: English. Language of Summary: Spanish; French. Number of References: Many ref. Registry Number: 14808-60-7, 7631-86-9.
KW - environmental health
KW - epidemiology
KW - evaluation
KW - human diseases
KW - neoplasms
KW - quartz
KW - respiratory diseases
KW - silica
KW - silicosis
KW - toxicology
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - lung diseases
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013025086&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Worker health and safety in a changing agricultural environment.
AU - Olenchock, S. A.
A2 - Dugger, P.
A2 - Richter, D. (Editors)
T2 - 2000 Proceedings Beltwide Cotton Conferences, San Antonio, USA, 4-8 January, 2000: Volume 1.
JO - 2000 Proceedings Beltwide Cotton Conferences, San Antonio, USA, 4-8 January, 2000: Volume 1.
JF - 2000 Proceedings Beltwide Cotton Conferences, San Antonio, USA, 4-8 January, 2000: Volume 1.
Y1 - 2000///
SP - 219
EP - 222
CY - Memphis; USA
PB - National Cotton Council
AD - Olenchock, S. A.: National Institute for Occupational Safety and Health, Morgantown, WV, USA.
N1 - Accession Number: 20002017517. Publication Type: Conference paper. Language: English. Number of References: 12 ref.
N2 - Changing demographics in the farming population and changes to the farm itself continue to represent new challenges and opportunities related to ensuring the health and safety of the farming community. While individual and partnership farms continue to decrease in number, the age of the remaining farm operators continues to increase. From 1982 to 1997, the number of farmers aged 65 years and older increased 24%, with the average age of 54.3 years for farm operators in 1997. Female farm operators continue to increase in numbers, as do Spanish, Hispanic or Latino operators. For the health and safety professional, these changes bring new concerns of slips and falls, reproductive hazards, and cultural acceptance of prevention messages and activities. This paper will update the current trends and discuss the potential effects on the health and safety of workers in agriculture.
KW - agriculture
KW - farmers
KW - farming
KW - farms
KW - health hazards
KW - occupational health
KW - safety at work
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - occupational safety
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20002017517&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Performance of a new ROPS on ASAE tests.
AU - Powers, J. R.
AU - Snyder, K. A.
AU - Harris, J. R.
AU - Ronaghi, M.
AU - Etherton, J. R.
AU - Newbraugh, B. H.
T2 - 2000 ASAE Annual International Meeting, Milwaukee, Wisconsin, USA, 9-12 July 2000
JO - 2000 ASAE Annual International Meeting, Milwaukee, Wisconsin, USA, 9-12 July 2000
JF - 2000 ASAE Annual International Meeting, Milwaukee, Wisconsin, USA, 9-12 July 2000
Y1 - 2000///
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
AD - Powers, J. R.: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 20003025050. Publication Type: Bulletin article; Conference paper. Language: English. Number of References: 14 ref. Subject Subsets: Agricultural Engineering
N2 - Each year hundreds of people die as a result of agricultural tractor overturns. The use of rollover protective structures (ROPS), along with seat belts, is the best known method for preventing these fatalities. One impediment to ROPS use, however, is low clearance situations, such as orchards and animal confinement buildings. To address the need for ROPS that are easily adapted to low clearance situations, NIOSH researchers have developed a prototype automatically deploying, telescoping ROPS (AutoROPS). The AutoROPS is normally latched in its lowered position for day-to-day use. If an overturn condition is detected by the sensor, the retracted ROPS will deploy and lock in the full upright position before ground contact. Static load testing and field upset tests of the AutoROPS have been conducted in accordance with SAE standard J2194. Additionally, timed trials of the AutoROPS deployment mechanism have been completed. The results of these tests show that the AutoROPS is a viable device that could be used to help prevent deaths due to tractor overturns.
KW - accidents
KW - overturning
KW - performance
KW - roll over protection structures
KW - tests
KW - tractors
KW - antiroll structures
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20003025050&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Caloric intake as a modulator of carcinogenicity and anticarcinogenicity.
AU - Hart, R. W.
AU - Bucci, T.
AU - Seng, J.
AU - Turturro, A.
AU - Leakey, J. E. A.
AU - Feuers, R.
AU - Duffy, P.
AU - James, J.
AU - Lyn-Cook, B.
AU - Pipkin, J.
AU - Li, S. Y.
A2 - Eisenbrand, G.
A2 - Dayan, A. D.
A2 - Elias, P. S.
A2 - Grunow, W.
A2 - Schlatter, J.
T2 - Carcinogenic/anticarcinogenic factors in food: novel concepts?, DFG symposium, Kaiserslauten, Germany, 4-7 October, 1998
Y1 - 2000///
CY - Weinheim; Germany
PB - Wiley-VCH Verlag GmbH
SN - 3527271449
AD - Hart, R. W.: National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20013090975. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - This article discusses the relationship of body weight to cancer and explains the mechanism in which caloric intake modifies homeostatic processes believed to be critical in determining the ability of an organism to cope with endogenous and exogenous stress such as chemical, physical and biological carcinogens. The response of the organism (physiological, metabolic, molecular and cellular) to such stress is described.
KW - body weight
KW - caloric intake
KW - carcinogens
KW - homeostasis
KW - neoplasms
KW - reviews
KW - cancers
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013090975&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Treatment of lymphatic filariasis.
AU - Addiss, D. G.
AU - Dreyer, G.
A2 - Nutman, T. B.
T2 - Lymphatic filariasis.
Y1 - 2000///
CY - London; UK
PB - Imperial College Press
SN - 1860940595
AD - Addiss, D. G.: Mailstop F-22, Division of Parasitic Diseases, National Center for Infectious Diseases, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Atlanta, GA, 30341, USA.
N1 - Accession Number: 20000806607. Publication Type: Book chapter. Language: English. Number of References: 222 ref. Subject Subsets: Helminthology
N2 - This chapter briefly reviews tools for the diagnosis and post-treatment follow-up of filarial infections (Wuchereria bancrofti, Brugia malayi) and then discusses the treatment of lymphatic filariasis with regard to asymptomatic or subclinical lymphatic filariasis, acute and chronic manifestations of lymphatic filariasis, urogenital manifestations, tropical pulmonary eosinophilia, antifilarial chemotherapy, and community-based treatment of lymphatic filariasis.
KW - animal parasitic nematodes
KW - anthelmintics
KW - drug therapy
KW - helminths
KW - human diseases
KW - lymphatic filariasis
KW - parasites
KW - reviews
KW - therapy
KW - Brugia malayi
KW - man
KW - Wuchereria bancrofti
KW - Brugia
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Wuchereria
KW - animal-parasitic nematodes
KW - chemotherapy
KW - nematode parasites of animals
KW - nematodes
KW - nematodes of animals
KW - parasitic worms
KW - Secernentea
KW - Spirurida
KW - therapeutics
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20000806607&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of Dengue virus type 2 replicons capable of prolonged expression in host cells.
AU - Pang, X. W.
AU - Zhang, M. J.
AU - Dayton, A. I.
JO - BMC Microbiology
JF - BMC Microbiology
Y1 - 2001///
VL - 1
IS - 18
SP - (24 August 2001)
EP - (24 August 2001)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2180
AD - Pang, X. W.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.
N1 - Accession Number: 20043155055. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - Background: As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the possibility of designing Dengue vaccines based on non-structural proteins. Results: Dengue constructs which lack major structural proteins replicate intracellularly in tissue culture. These replicons are capable of prolonged expression of Dengue virus non-structural proteins for at least seven days in culture. Conclusion: Dengue virus genomes lacking major structural proteins can, like other flaviviruses, replicate intracellularly and express virus non-structural proteins with minimal toxicity to host cells. These findings pave the way for the development of dengue virus replicons as a form of live, attenuated virus vaccine.
KW - dengue
KW - live vaccines
KW - proteins
KW - replication
KW - tissue culture
KW - vaccine development
KW - dengue 2 virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - attenuated vaccines
KW - replicons
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043155055&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2180/1/18/abstract
UR - email: dayton@cber.fda.gov\dayton@cber.fda.gov\dayton@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV.
AU - Pang, X. W.
AU - Zhang, M. J.
AU - Dayton, A. I.
JO - BMC Microbiology
JF - BMC Microbiology
Y1 - 2001///
VL - 1
IS - 28
SP - (13 November 2001)
EP - (13 November 2001)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2180
AD - Pang, X. W.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.
N1 - Accession Number: 20043155060. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - Background: Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against dengue virus and HIV, we have attempted to create vectors which express dengue virus non-structural proteins and HIV immunogens. Previously we reported the successful construction of dengue virus replicons which lack structural genes necessary for virion release and spreading infection in culture but which can replicate intracellularly and abundantly produce dengue non-structural proteins. Here we attempted to express heterologous genetic material from these replicons. Results: We cloned into a Δpre-M/E dengue virus replicon genes for either green fluorescent protein (GFP), HIV gp160 or HIV gp120 and tested the ability of these constructs to express dengue virus proteins as well as the heterologous proteins in tissue culture after transfection of replicon RNA. Conclusions: Heterologous proteins were readily expressed from these constructs. GFP and gp120 demonstrated minimal or no toxicity. Gp160 expressing replicons were found to express proteins abundantly at 36 hours post transfection, but after 50 hrs of transfection, few replicon positive cells could be found despite the presence of cellular debris positive for replicon proteins. This suggested that gp160 expressed from dengue virus replicons is considerably more toxic than either GFP or gp120. The successful expression of heterologous proteins, including HIV gp120 for long periods in culture suggests this vector system may be useful as a vaccine vector, given appropriate delivery methods.
KW - dengue
KW - envelope protein gp120
KW - envelope protein gp160
KW - genes
KW - HIV-1 infections
KW - immunization
KW - proteins
KW - toxicity
KW - vaccination
KW - vaccine development
KW - vaccines
KW - dengue virus
KW - Human immunodeficiency virus 1
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - gp120
KW - gp160
KW - human immunodeficiency virus type 1
KW - immune sensitization
KW - replicons
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043155060&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2180/1/28/abstract
UR - email: pang@cber.fda.gov\zhangm@cber.fda.gov\aidayton@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunity and protection against Brucella abortus.
AU - Golding, B.
AU - Scott, D. E.
AU - Scharf, O.
AU - Huang, L. Y.
AU - Zaitseva, M.
AU - Lapham, C.
AU - Eller, N.
AU - Golding, H.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2001///
VL - 3
IS - 1
SP - 43
EP - 48
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 1286-4579
AD - Golding, B.: Division of Hematology, Office of Blood and Blood Research, Center for Biologics Research and Review, Food and Drug Administration, 1401 Woodmont, Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20013014490. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Brucella abortus is an intracellular pathogen that causes disease in cattle and in humans. The response against B. abortus involves the whole gamut of the immune system, from innate to adaptive immunity resulting from stimulation of antigen-presenting cells, NK cells, CD4+ and CD8+ T cells, and B cells.
KW - B lymphocytes
KW - immune response
KW - immune system
KW - immunity
KW - T lymphocytes
KW - Brucella
KW - Brucella abortus
KW - cattle
KW - man
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Brucella
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - antigen presenting cells
KW - B cells
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Animal Immunology (LL650) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013014490&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis.
AU - Gilmore, R. D., Jr.
AU - Mbow, M. L.
AU - Stevenson, B.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2001///
VL - 3
IS - 10
SP - 799
EP - 808
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 1286-4579
AD - Gilmore, R. D., Jr.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, P.O. Box 2087, Foothills Campus, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20013131275. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Borrelia burgdorferi exists in nature via an enzootic cycle whereby the organism must adapt to the diverse environmental conditions provided inside the arthropod transmission vector and the mammalian reservoir hosts. B. burgdorferi genes shown to be regulated by temperature, pH and/or cell density during the organism's growth in culture medium were assayed for expression during various stages of the tick feeding cycle by reverse transcription-polymerase chain reaction (RT-PCR). ospA, ospC, flaB, erpA/I/N, erpB/J/O, rev and mlpA, were transcriptionally active following that larval and nymphal stages of feeding as determined by qualitative RT-PCR. During tick resting periods between feedings, ospC, mlpA and rev transcription were undetectable, in contrast to ospA, flaB, erpA/I/N and erpB/J/O. bba64, a gene induced by environmental changes in culture and expressed during mammalian infection, was not detectable during any of the tick life cycle phases. Quantitative PCR to determine B. burgdorferi genome equivalents in these tick samples using DNA co-purified with the RNA allowed an estimation of gene expression relative to the numbers of B. burgdorferi present in the ticks. Although the spirochaete totals varied widely between individual tick pools of fed, replete nymphs, the relative expression ratios between individual target genes following a nymphal feed were comparable. Similarly, borrelial gene transcription from the larval feeding and the nymphal feeding were observed and compared. These findings analogize B. burgdorferi gene expression observed by environmental stimuli in vitro with the transcriptional activity occurring during the organism's infectious cycle within the tick.
KW - developmental stages
KW - disease vectors
KW - gene expression
KW - life cycle
KW - tickborne diseases
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - bacterium
KW - growth phase
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Reproduction, Development and Life Cycle (Wild Animals) (YY200) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013131275&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The irreversible cost of delayed diagnosis of tuberculosis in HIV co-infected persons in sub-Saharan Africa.
AU - Lawn, S. D.
AU - Griffin, G. E.
T2 - International Journal of Tuberculosis and Lung Disease
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
Y1 - 2001///
VL - 5
IS - 2
SP - 200
EP - 201
CY - Paris; France
PB - International Union Against Tuberculosis and Lung Disease (IUATLD)
SN - 1027-3719
AD - Lawn, S. D.: Tuberculosis and Mycobacteriology Branch, National Center for Infectious Diseases, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Dept. of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20013109433. Publication Type: Correspondence. Language: English. Number of References: 10 ref. Subject Subsets: Tropical Diseases
KW - antituberculous agents
KW - antiviral agents
KW - diagnosis
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - opportunistic infections
KW - tuberculosis
KW - Ghana
KW - man
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - bacterium
KW - chemotherapy
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013109433&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Why tuberculosis control in an unstable country is essential: desperate TB patients embrace DOTS in Angola.
AU - Doveren, R. F. C.
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
Y1 - 2001///
VL - 5
IS - 5
SP - 486
EP - 488
CY - Paris; France
PB - International Union Against Tuberculosis and Lung Disease (IUATLD)
SN - 1027-3719
AD - Doveren, R. F. C.: Public Health Service Rotterdam, Department of Infectious Diseases, Rotterdam, Netherlands.
N1 - Accession Number: 20013103304. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 4 ref. Subject Subsets: Rural Development; Tropical Diseases
KW - disease control
KW - drug therapy
KW - health programs
KW - human diseases
KW - tuberculosis
KW - Angola
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Developing Countries
KW - Portuguese Speaking Africa
KW - Africa
KW - SADC Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - bacterium
KW - chemotherapy
KW - directly observed therapy/DOTS
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013103304&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Performance of an automatically deployable ROPS on ASAE tests.
AU - Powers, J. R.
AU - Harris, J. R.
AU - Etherton, J. R.
AU - Snyder, K. A.
AU - Ronaghi, M.
AU - Newbraugh, B. H.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2001///
VL - 7
IS - 1
SP - 51
EP - 61
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Powers, J. R.: Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop P119, Morgantown, WV 26505, USA.
N1 - Accession Number: 20013085140. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Agricultural Engineering
N2 - In USA, ~132 agricultural tractor overturn fatalities occur per year. The use of rollover protective structures (ROPS), along with seat belts, is the best-known method for preventing these fatalities. However, one impediment to ROPS use is low-clearance situations, such as orchards and animal confinement buildings. To address the need for ROPS that are easily adapted to low-clearance situations, the Division of Safety Research, National Institute for Occupational Safety and Health, developed a prototype automatically deploying, telescoping ROPS (AutoROPS). The NIOSH AutoROPS consists of two subsystems. The first is a retractable ROPS that is normally latched in its lowered position for day-to-day use. The second subsystem is a sensor that monitors the operating angle of the tractor. If an overturn condition is detected by the sensor, the retracted ROPS will deploy and lock in the full upright position before ground contact. Static load testing and field upset tests of the NIOSH AutoROPS have been conducted in accordance with SAE standard J2194. Additionally, timed trials of the AutoROPS deployment mechanism were completed. The results of these tests show that the NIOSH AutoROPS has significant potential to overcome the limitations of current ROPS designs for use in low clearance as well as unrestricted clearance operations.
KW - automation
KW - farm equipment
KW - low profile tractors
KW - protective structures
KW - safety at work
KW - safety devices
KW - springs
KW - suspension systems
KW - occupational safety
KW - Automation and Control (NN050)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013085140&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatal on-farm injuries among youth 16 to 19 years of age: 1982-1994.
AU - Myers, J. R.
AU - Adekoya, N.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2001///
VL - 7
IS - 2
SP - 101
EP - 112
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Myers, J. R.: Division of Safety Research, National Institute for Occupational Safety and Health, Mail Stop 1812, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20013120017. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health; Agricultural Engineering
N2 - Data from the Vital Statistics Mortality (VSM) public use file and the National Traumatic Occupational Fatalities (NTOF) surveillance systems were used to describe fatal injuries among youth 16-19 years of age in the USA that occurred on farms for the years 1982 through 1994. The VSM captures all deaths in the USA, while the NTOF only captures occupational injury deaths. There were 550 total on-farm fatalities to youth 16-19 years of age in the VSM, and 221 occupational on-farm deaths from the NTOF for the same age group. These numbers suggest that 40% of the on-farm deaths were occupational. It was found that the proportions of deaths attributable to work increased with age. Fatality rates for on-farm non-occupational deaths decreased slightly during the time period (from 8.4 deaths/100 000 for 1982-85 to 6.8 deaths/100 000 for 1991-94), while on-farm occupational fatality rates dropped dramatically (12.0 deaths/100 000 for 1982-85 down to 4.9 deaths/100 000 for 1991-94). The leading causes of death for on-farm occupational fatalities were machinery (54%) and electrical current (20%). The most common causes of on-farm fatalities that were non-occupational were drowning (38.9%) and firearms (28.6%). For the years 1991 through 1994, drowning and firearms accounted for approximately the same number of on-farm deaths as machinery. Non-occupational risks are a concern for youth 16-19 years of age on the farm.
KW - causes of death
KW - death
KW - electric current
KW - electrocution
KW - equipment
KW - farms
KW - mortality
KW - occupational hazards
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - electrical current
KW - United States of America
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Demography (UU200)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013120017&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developing new smallpox vaccines.
AU - Rosenthal, S. R.
AU - Merchlinsky, M.
AU - Kleppinger, C.
AU - Goldenthal, K. L.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2001///
VL - 7
IS - 6
SP - 920
EP - 926
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Rosenthal, S. R.: CBER/Food and Drug Administration, HFM-475, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20013179938. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Public Health
N2 - New stockpiles of smallpox vaccine are required as a contingency for protecting civilian and military personnel against deliberate dissemination of smallpox virus by terrorists or unfriendly governments. The smallpox vaccine in the current stockpile consists of a live animal poxvirus (vaccinia virus (VACV)) that was grown on the skin of calves. Because of potential issues with controlling this earlier manufacturing process, which included scraping VACV lesions from calfskin, new vaccines are being developed and manufactured by using viral propagation on well-characterized cell substrates. We describe, from a regulatory perspective, the various strains of VACV, the adverse events associated with calf lymph-propagated smallpox vaccine, the issues regarding selection and use of cell substrates for vaccine production, and the issues involved in demonstrating evidence of safety and efficacy.
KW - adverse effects
KW - biological warfare
KW - calves
KW - efficacy
KW - live vaccines
KW - reviews
KW - safety
KW - smallpox
KW - strains
KW - substrates
KW - vaccine development
KW - vaccinia virus
KW - variola virus
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - adverse reactions
KW - attenuated vaccines
KW - Host Resistance and Immunity (HH600)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013179938&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adventitious agents and vaccines.
AU - Krause, P. R.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2001///
VL - 7
SP - 562
EP - 562
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Krause, P. R.: Food and Drug Administration, Building 29A, Room 1C16, HRM-457, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20013114589. Publication Type: Journal Article; Conference paper. Language: English.
KW - disease prevention
KW - emerging infectious diseases
KW - public health
KW - vaccines
KW - adventitious agents
KW - emerging diseases
KW - emerging infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013114589&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet.
AU - Poirier, L. A.
AU - Wise, C. K.
AU - Delongchamp, R. R.
AU - Sinha, R.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2001///
VL - 10
IS - 6
SP - 649
EP - 655
CY - Philadelphia; USA
PB - American Association for Cancer Research Inc.
SN - 1055-9965
AD - Poirier, L. A.: Division of Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013102622. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 979-92-0, 29908-03-0, 59-30-3, 6027-13-0, 65-23-6. Subject Subsets: Human Nutrition
N2 - An increasing number of both clinical and experimental studies have shown an association between deficiencies of the dietary sources of physiological methyl groups and cancer formation. The critical metabolic intermediate in the determination of methylation status is S-adenosylmethionine (SAM), the body's chief physiological methyl donor. The present study examined the erythrocyte levels of SAM and of its demethylated metabolite S-adenosylhomocysteine (SAH) in 66 normal subjects (33 men and 33 women), whose blood had been drawn at days 0, 7 and 14 of an experimental period during which they were fed a fixed diet. These subjects were recruited as volunteers from Beltsville area in Maryland, USA [date not given]. The plasma levels of homocysteine (HCys) were also determined in the same individuals at the same time points. In addition, the subjects had completed a food frequency questionnaire (FFQ) describing their usual dietary habits before being placed on the dietary regimen. The blood levels of SAM, SAH, and HCys were compared with the dietary intakes of folate, vitamin B6, fats, and calories, both prior to using the FFQ and during the experimental period. Results indicated that the intraindividual differences were very low, but the interindividual differences were large for the values of SAM, SAH, SAM: SAH ratios, and HCys. Interestingly, the blood levels of SAM and HCys were higher in men than in women and generally showed the expected correlations with folate intake i.e., positive for SAM and negative for HCys. The intakes of folate (276 µg/day) and B6 (1.87 mg/day) during the 2-week experimental period were relatively low compared with the usual intakes of these vitamins (375 and 2.06 mg/day for folate and B6, respectively) but correlated well with each other during both periods of the study. Surprisingly, both men and women showed a significant rise in erythrocyte SAM:SAH ratios as a function of age. In addition, the combined results from men and women, even adjusted for gender, showed significant correlations between HCys and both weight and body mass index. On the other hand, during the experimental period of the study, blood SAM levels were inversely correlated with the intakes of both fat and calories when the data for both men and women were combined and adjusted for gender. The blood determinations of SAM and related compounds showed a high degree of reproducibility over time and thus appear to provide a practical marker of methylation status for the assessment of cancer risk from dietary, environmental, and genetic factors.
KW - adenosylhomocysteine
KW - adenosylmethionine
KW - body mass index
KW - body weight
KW - caloric intake
KW - fat consumption
KW - folic acid
KW - homocysteine
KW - men
KW - nutrient intake
KW - pyridoxine
KW - sex differences
KW - women
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - folacin
KW - folate
KW - United States of America
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The epidemiology of hospitalization of elderly Americans for septicemia or bacteremia in 1991-1998: application of medicare claims data.
AU - Baine, W. B.
AU - Yu, W.
AU - Summe, J. P.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2001///
VL - 11
IS - 2
SP - 118
EP - 126
CY - New York; USA
PB - Elsevier Science Inc.
SN - 1047-2797
AD - Baine, W. B.: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, 6010 Executive Boulevard, Rockville, MD 20852-3813, USA.
N1 - Accession Number: 20013025970. Publication Type: Journal Article. Language: English. Number of References: 30 ref.
N2 - The epidemiology of hospitalization of elderly Americans for septicaemia or bacteraemia was examined. Medicare claims data for discharges from 1991 through 1998 were used to study 75,920 hospitalizations with the principal diagnosis of septicaemia or bacteraemia in patients aged 65 years or older. "Unspecified septicemia" was the commonest principal diagnosis, followed by septicaemia due to Escherichia coli or staphylococci. From 1991 through 1997, annual discharges for "unspecified septicemia" increased 108, and those for pneumococcal septicaemia increased 310%. Decreases in reported septicaemia were seen after increases in the proportion of beneficiaries in Medicare health maintenance organizations. Discharge rates for septicaemia principal diagnoses increased steeply with age. Age-specific discharge rates were usually highest for black men and lowest for white women. Exceptions included septicaemia due to E. coli, with white men at low risk, and pneumococcal septicaemia, without significant differences between races or sexes. The case-fatality rate in hospital ranged from 4.2% with "bacteremia" and 6.9% with E. coli septicaemia to 22.2% with "septicemia due to gram-negative organism, unspecified," and 26.8% with "unspecified septicaemia." Staphylococcal septicaemia, septicaemia due to pseudomonas, and septicaemia due to anaerobes were the costliest common principal diagnoses in terms of the mean duration of hospital stay. Unexplained sharp increases were reported in hospitalization for septicaemia or bacteraemia in elderly Americans. Marked variation by race and sex were evident in discharge rates with these principal diagnoses. Prognosis and average cost of treatment also differed substantially among common rubrics. Further investigation of individual diagnoses should concentrate on explaining secular trends, exploring the basis for variation by race and sex, and elucidating risk factors for poor clinical outcomes.
KW - age differences
KW - anaerobes
KW - bacteraemia
KW - elderly
KW - epidemiology
KW - gram negative bacteria
KW - human diseases
KW - prognosis
KW - risk factors
KW - septicaemia
KW - Bacteria
KW - man
KW - Staphylococcus
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - aged
KW - anaerobic micro-organisms
KW - anaerobic microorganisms
KW - bacteremia
KW - bacterium
KW - blood poisoning
KW - elderly people
KW - older adults
KW - senior citizens
KW - septicemia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013025970&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: implications for chronic studies.
AU - Duffy, P. H.
AU - Seng, J. E.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - Aidoo, A.
AU - Hattan, D. G.
AU - Casciano, D. A.
AU - Feuers, R. J.
JO - Aging, Clinical and Experimental Research
JF - Aging, Clinical and Experimental Research
Y1 - 2001///
VL - 13
IS - 4
SP - 263
EP - 272
CY - Milano; Italy
PB - Editrice Kurtis s.r.l.
SN - 0394-9532
AD - Duffy, P. H.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20023127165. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A study was undertaken to determine the effects of incremental levels of dietary restriction (DR) in rats. Survival, growth, reproductive, and dietary intake (DI) variables were monitored in a chronic study in which male Sprague Dawley (SD) rats (NCTR colony) were fed their ration ad libitum (AL), or DR. The main objectives were to determine if low levels of DR could be used to increase the survival rate of SD rats in the chronic bioassay, and to identify the survival characteristics of a long-lived SD rat strain (NCTR colony). The average life span of AL rats was 115 months. At 104 weeks on study (110 weeks of age), the survival rate for the AL and 10%, 25%, and 40% DR groups was 63.4, 87.5, 87.5, and 97.5%, respectively. The largest increase in survival (24.1%) occurred between AL and 10% DR, indicating that very low levels of DR have a significant effect on survival. Whole-body, liver, prostate, and epididymis weights and body length were decreased by DR, whereas brain weight, testicular weight, and skull length were not altered by DR. Rats from the NCTR colony were found to be ideal for chronic studies because they are much longer-lived than other SD stocks. Although the 104-week survival rate for these SD, non-obese AL rats exceeds the FDA's "Redbook" survival guideline (>50%) for chronic bioassays, the use of DR is advocated because it reduces individual variability in body weight.
KW - aging
KW - animal models
KW - body weight
KW - food intake
KW - growth
KW - laboratory animals
KW - reproductive performance
KW - restricted feeding
KW - survival
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ageing
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023127165&site=ehost-live&scope=site
UR - email: pduffy@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Proposed changes in U.S.A. regulations for food labeling.
AU - Wilkening, V.
A2 - Himes, J. H.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2001///
VL - 14
IS - 3
SP - 309
EP - 314
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Wilkening, V.: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20013094545. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 4 ref. Subject Subsets: Public Health; Human Nutrition
N2 - The article discusses the proposed rule by the USFDA for the declaration of trans fatty acids in nutrition labelling and limiting it wherever saturated fat limits are placed on nutrient content or health claims. Other options for declaring trans fatty acids were discussed and comments requested.
KW - diet
KW - foods
KW - labelling
KW - nutrient content
KW - nutrition
KW - reviews
KW - saturated fats
KW - trans fatty acids
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - labeling
KW - labels
KW - Laws and Regulations (DD500)
KW - Food Composition and Quality (QQ500)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013094545&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contribution of immune activation to pathogenesis and transmission of human immunodeficiency virus type 1 infection.
AU - Lawn, S. D.
AU - Butera, S. T.
AU - Folks, T. M.
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
Y1 - 2001///
VL - 14
IS - 4
SP - 753
EP - 777
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0893-8512
AD - Lawn, S. D.: HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20013155597. Publication Type: Journal Article. Language: English. Number of References: 377 ref. Subject Subsets: Dairy Science; Public Health
N2 - The life cycle of human immunodeficiency virus type 1 (HIV-1) is intricately related to the activation state of the host cells supporting viral replication. Although cellular activation is essential to mount an effective host immune response to invading pathogens, paradoxically the marked systemic immune activation that accompanies HIV-1 infection in vivo may play an important role in sustaining phenomenal rates of HIV-1 replication in infected persons. Moreover, by inducing CD4+ cell loss by apoptosis, immune activation may further be central to the increased rate of CD4+ cell turnover and eventual development of CD4+ lymphocytopenia. In addition to HIV-1-induced immune activation, exogenous immune stimuli such as opportunistic infections may further impact the rate of HIV-1 replication systemically or at localized anatomical sites. Such stimuli may also lead to genotypic and phenotypic changes in the virus pool. Together, these various immunological effects on the biology of HIV-1 may potentially enhance disease progression in HIV-infected persons and may ultimately outweigh the beneficial aspects of antiviral immune responses. This may be particularly important for those living in developing countries, where there is little or no access to antiretroviral drugs and where frequent exposure to pathogenic organisms sustains a chronically heightened state of immune activation. Moreover, immune activation associated with sexually transmitted diseases, chorio-amnionitis, and mastitis may have important local effects on HIV-1 replication that may increase the risk of sexual or mother-to-child transmission of HIV-1. The aim of this paper is to provide a broad review of the interrelationship between immune activation and the immunopathogenesis, transmission, progression, and treatment of HIV-1 infection in vivo.
KW - apoptosis
KW - CD4+ lymphocytes
KW - disease course
KW - disease transmission
KW - HIV-1 infections
KW - human diseases
KW - immune response
KW - immunity
KW - immunopathology
KW - lymphocyte transformation
KW - mastitis
KW - reviews
KW - sexually transmitted diseases
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CD4+ cells
KW - disease progression
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - STDs
KW - T4 lymphocytes
KW - venereal diseases
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013155597&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk analysis in action.
AU - Yang KyuHwan
JO - Biomedical and Environmental Sciences
JF - Biomedical and Environmental Sciences
Y1 - 2001///
VL - 14
IS - 1/2
SP - 30
EP - 31
CY - Beijing; China
PB - Chinese Academy of Preventive Medicine
SN - 0895-3988
AD - Yang KyuHwan: Korea Food and Drug Administration, # 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20013140846. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
KW - food quality
KW - food safety
KW - risk assessment
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - South Korea
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013140846&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antisense modulation of 5,10-methylenetetrahydrofolate reductase expression produces neural tube defects in mouse embryos.
AU - Hansen, D. K.
AU - Barbee, S. A.
AU - Grafton, T. F.
AU - Gu, Y.
AU - Streck, R. D.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2001///
VL - 15
IS - 1
SP - 21
EP - 29
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0890-6238
AD - Hansen, D. K.: Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20013146535. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 63-68-3, 9028-69-7, 59-30-3. Subject Subsets: Human Nutrition; Animal Breeding; Agricultural Biotechnology
N2 - The role of folate metabolism in producing neural tube defects (NTDs) in humans is unknown. In the current study, antisense oligodeoxyribonucleotide technology was utilized to disrupt normal expression of the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) in organogenesis-stage mouse embryos. Two different antisense probes were microinjected into the amniotic sac of gestation day (GD) 8 mouse embryos with PBS or scrambled sense oligodeoxyribonucleotides injected into control embryos. Concentration-dependent increases in the frequencies of embryos with NTDs were observed for both antisense sequences. The level of mRNA for MTHFR was decreased in embryos treated with the higher concentration of one antisense sequence, indicating that the sequence is able to decrease gene expression. 5-methyltetrahydrofolate, the product of the MTHFR reaction, was able to decrease the incidence of antisense-induced NTDs, but co-injection with L-methionine did not. These results suggest that reduced expression of MTHFR may play a role in producing NTDs.
KW - amnion
KW - animal models
KW - antisense DNA
KW - embryos
KW - folic acid
KW - gene expression
KW - messenger RNA
KW - metabolism
KW - methionine
KW - methylenetetrahydrofolate reductase
KW - organogenesis
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - folacin
KW - folate
KW - mRNA
KW - neural tube defect
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013146535&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Placental transfer of the soya isoflavone genistein following dietary and gavage administration to Sprague Dawley rats.
AU - Doerge, D. R.
AU - Churchwell, M. I.
AU - Chang, H. C.
AU - Newbold, R. R.
AU - Delclos, K. B.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2001///
VL - 15
IS - 2
SP - 105
EP - 110
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0890-6238
AD - Doerge, D. R.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023072306. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 446-72-0. Subject Subsets: Soyabeans; Human Nutrition
N2 - Genistein, the principal soya isoflavone, has oestrogenic activity and is widely consumed by humans for putative beneficial health effects. The goal of the present study was to measure placental transfer of genistein in rats as a possible route of developmental exposure. Pregnant Sprague-Dawley rats were administered genistein orally, either by diet or by gavage. Concentrations of genistein aglycone and conjugates were measured in maternal and offspring serum and brain using HPLC with isotope dilution electrospray tandem mass spectrometry. Although fetal or neonatal serum concentrations of total genistein were approximately 20-fold lower than maternal serum concentrations, the biologically active genistein aglycone concentration was only 5-fold lower. Fetal brain contained predominantly genistein aglycone at levels similar to those in the maternal brain. These studies show that genistein aglycone crosses the rat placenta and can reach fetal brain from maternal serum genistein levels that are relevant to those-observed in humans.
KW - animal models
KW - brain
KW - fetus
KW - genistein
KW - isoflavones
KW - mothers
KW - placenta
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - cerebrum
KW - foetus
KW - genistein aglycone
KW - placental transfer
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023072306&site=ehost-live&scope=site
UR - email: ddoerge@netr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. against hepatitis B virus.
AU - Kim TaeGyun
AU - Kang SeogYoun
AU - Jung KiKyung
AU - Kang JuHye
AU - Lee Euna
AU - Han HyungMee
AU - Kim SeungHee
JO - Phytotherapy Research
JF - Phytotherapy Research
Y1 - 2001///
VL - 15
IS - 8
SP - 718
EP - 720
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0951-418X
AD - Kim TaeGyun: Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20023004280. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Botanical Pesticides
N2 - The antiviral effects of aqueous extracts of T. chebula [Terminalia chebula], S. officinalis, Rubus coreanus and Rheum palmatum were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8-day treatment. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to 128 µg/ml and inhibited the secretion of HBsAg dose dependently. Of the four tested plants, T. chebula exhibited the most prominent anti-HBV activities.
KW - antiviral properties
KW - cell culture
KW - cell lines
KW - hepatitis B
KW - medicinal plants
KW - plant extracts
KW - wild relatives
KW - hepatitis B virus
KW - man
KW - Rheum palmatum
KW - Rubus
KW - Sanguisorba officinalis
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rheum
KW - Polygonaceae
KW - Polygonales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Rosaceae
KW - Rosales
KW - Sanguisorba
KW - Rubus
KW - anti-viral properties
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Rubus coreanus
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023004280&site=ehost-live&scope=site
UR - email: biokim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of long-term efficacy of hepatitis B vaccine.
AU - Ayerbe, M. C.
AU - Pérez-Rivilla, A.
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
Y1 - 2001///
VL - 17
IS - 2
SP - 151
EP - 156
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0393-2990
AD - Ayerbe, M. C.: Department of Public Health Service, Gerencia Atención Primaria Área Sanitaria 8 of Madrid, Madrid, Spain.
N1 - Accession Number: 20013142684. Publication Type: Journal Article. Corporate Author: Spain, ICOVAHB group Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - In a healthy cohort of 462 subjects in Spain in which hepatitis B vaccine was administered between 1990 and 1992, a follow-up study was carried out to determine the duration of protection. Individuals with antibody against the hepatitis B virus surface antigen (anti-HBs) titre lower than 100 mIU/ml were administered a booster dose and antibodies determined 30 days later. The proportion of protection 6.5 years after vaccination was 85% (95% CI: 82-88). Only nine vaccinees seroconverted to anti-HBc positivity without becoming a carrier or ill. In 125 subjects in which a booster dose was administered, a significant increase in geometric mean of anti-HBs titre was observed (609 mIU/ml) as compared to late (13 mIU/ml) and early post-vaccination antibody levels (256 mIU/ml, Wilcoxon's test, p<0.001) suggesting the existence of an anamnestic response. We conclude that in the immunocompetent population, it is not necessary to administer a booster dose 6.5 years after hepatitis B vaccination.
KW - antibodies
KW - efficacy
KW - hepatitis B
KW - human diseases
KW - immune response
KW - immunization
KW - vaccination
KW - vaccines
KW - Spain
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013142684&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A quantitative risk assessment for fumonisins B1 and B2 in US corn.
AU - Humphreys, S. H.
AU - Carrington, C.
AU - Bolger, M.
A2 - Scott, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 3
SP - 211
EP - 220
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Humphreys, S. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013131257. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 44 ref. Subject Subsets: Postharvest Research; Human Nutrition; Public Health; Maize; Medical & Veterinary Mycology
N2 - Quantitative risk analysis permits modifying risk estimates with changes in variables such as exposure. This analysis for exposure to the mycotoxin fumonisin describes the magnitude of adverse effects, variability in the population and uncertainty of models as a range of possible outcomes. The most sensitive adverse response in rats, nephrotoxic lesions, was used for the dose-response analysis. Dietary intake of maize products was estimated from a 3-day consumption survey. Levels of corn in each product were estimated by standard methods. Fumonisin levels in corn products were estimated from Food and Drug Administration (FDA) surveillance data and distributions of fumonisin consumption were modelled for each eater in the survey population. Uncertainty for predictions made from each model and uncertainty resulting from model selection were described. Results of the dose-response and exposure analyses were assimilated in a two-dimensional Monte-Carlo simulation. Distributions representing variability and uncertainty were iteratively selected to form an array of estimates of the risk. On the basis of this analysis, current dietary levels of fumonisin would not result in renal lesions even at upper levels of exposure. To avoid toxicity at much higher doses, limiting corn intake would be more effective than would limiting the level of fumonisin in corn.
KW - diets
KW - food contamination
KW - food intake
KW - fumonisins
KW - kidneys
KW - laboratory animals
KW - maize
KW - nephrotoxicity
KW - risk assessment
KW - USA
KW - man
KW - rats
KW - Zea mays
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - corn
KW - food contaminants
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
KW - Animal Models of Human Nutrition (VV140)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013131257&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet.
AU - Kodell, R. L.
AU - Young, J. F.
AU - Delongchamp, R. R.
AU - Turturro, A.
AU - Chen, J. J.
AU - Gaylor, D. W.
AU - Howard, P. C.
AU - Zheng, Q.
A2 - Scott, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 3
SP - 237
EP - 253
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Kodell, R. L.: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013131262. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Data from the National Toxicology Program's carcinogenesis study of fumonisin B1 in B6C3F1 mice, conducted at the National Center for Toxicological Research, were used to fit the Moolgavkar-Venzon-Knudson (MVK) two-stage, clonal-expansion model of carcinogenesis. In addition to tumour data from the conventional 2-year bioassay, the study included data on tissue weights, cell proliferation, cell death, and sphingolipid metabolism in primary target organs. The model was used to predict 2-year liver tumour rates in female and male mice based on differences among dose groups in the effect of fumonisin B1 on the growth of normal tissue and on the proliferation of preneoplastic cells as a compensatory response to sphinganine-induced cell death. Fumonisin B1 was assumed to be non-genotoxic, i.e. the model did not include any effect of fumonisin B1 on either of the two mutation rates of the MVK model. The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B1 in females.
KW - carcinogenesis
KW - diets
KW - fumonisins
KW - genotoxicity
KW - laboratory animals
KW - lipid metabolism
KW - liver
KW - liver cancer
KW - mathematical models
KW - neoplasms
KW - risk assessment
KW - risk factors
KW - sphingolipids
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - fat metabolism
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Toxinology (VV820) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013131262&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tissue sphinganine as a biomarker of fumonisin-induced apoptosis.
AU - Delongchamp, R. R.
AU - Young, J. F.
A2 - Scott, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 3
SP - 255
EP - 261
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Delongchamp, R. R.: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013131264. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - NCTR measured sphinganine concentrations in the livers of mice and in the livers and kidneys of rats in conjunction with a tumour bioassay. In our model of the tumour incidence, target-tissue levels of sphinganine serve as a biomarker for a dose response of fumonisin B1 on cell death. Initially we questioned the utility of sphinganine levels in this role because they were highly variable when compared across time points. In spite of this concern, conceptual framework and data are presented that support the use of sphinganine as a biomarker for a dose response of fumonisin B1 on cell death. This framework is reasonably consistent with observed sphinganine concentrations in the examined tissues, the literature on fumonisin's effects on sphingolipid synthesis, and our hypothesized mechanism through which fumonisin B1 increases age-specific tumour incidence.
KW - apoptosis
KW - carcinogenesis
KW - cytotoxicity
KW - diets
KW - fumonisins
KW - laboratory animals
KW - liver
KW - mathematical models
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - sphinganine
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013131264&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure assessment of dioxins/furans consumed in dairy foods and fish.
AU - Jensen, E.
AU - Bolger, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 5
SP - 395
EP - 403
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Jensen, E.: Center for Food Safety and Applied Nutrition, US Food Drug Administration, HFS-246, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013131802. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Dairy Science
N2 - Dioxins/furans are ubiquitous environmental contaminants whose primary route of human exposure occurs via the consumption of fatty foods of animal origin. The US FDA conducted a market basket survey of dairy products and commercial fish and shellfish to obtain data on levels of 17 dioxin/furan congeners (2, 3, 7, 8-congeners) in the US. The dairy products sampled included various cheeses (American, cheddar, Swiss, cottage), ice cream, yoghurt, butter, and milk. The finfish and shellfish (molluscs and crustacea) sampled are those marine species consumed in the greatest amounts and include canned tuna, shrimp, cod, blue crab, and oysters. Catfish was sampled because it is the dominant aquaculture species. Samples were collected in 1995-96 and analysis for 17 dioxin/furan congeners was performed by high-resolution gas chromatography following extraction and clean-up. Limits of detection (LOD) and quantitation (LOQ) for each congener in each food were reported. Point estimates of exposure were calculated using a 3-day (1-day diary plus 2-day recall) food consumption survey for eaters-only and for the general population (USDA/CSFII, 1989-92). Toxicity equivalency factors (TEFs) developed by the World Health Organization (1997) were used to derive overall dioxin/furan toxicity equivalents (TEQ) for each sample food. Mean estimates of TEQ exposure for each food were derived using five values for non-detects (ND=0; ND=1/2 LOD or LOQ; ND=LOD or LOQ) on both a total sample and eaters-only basis. Using zero and the LOD provide lower and upper bounds on the range of estimated exposure, respectively. The bounds on mean dioxin intakes (pg/person per day) calculated for consumers of specific foods were estimated as follows (using zero or LOD for non-detects): butter (0.5-11), cheese (1.6-3.2), ice cream (4-19), yoghurt (0.8-28), catfish (148-150), fish (other than catfish) (0.03-9), crustacea (32-35), mollusks (16.1-16.6), and shrimp (0.09-4.5). Exposure estimates derived by the five ND-methods are strongly dependent on the LOD and LOQ and represent upper bound estimates of exposure. Uncertainty in the exposure estimates is reduced with refinements in the analytical method.
KW - butter
KW - Cheddar cheese
KW - cheeses
KW - cottage cheese
KW - dioxins
KW - food contamination
KW - food safety
KW - furans
KW - ice cream
KW - milk
KW - milk products
KW - oysters
KW - seafoods
KW - shrimps
KW - Swiss cheese
KW - yoghurt
KW - USA
KW - cod
KW - crabs
KW - Ictalurus punctatus
KW - tuna
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - Gadus
KW - Gadidae
KW - Gadiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Scombridae
KW - Perciformes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - American cheese
KW - dairy products
KW - food contaminants
KW - joghurt
KW - United States of America
KW - yogurt
KW - Milk and Dairy Produce (QQ010)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013131802&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk analysis and the law: international law, the World Trade Organization, Codex Alimentarius and national legislation.
AU - Horton, L. R.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 12
SP - 1057
EP - 1067
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Horton, L. R.: Office of the Commissioner, US Food and Drug Administration, 5600 Fishers Lane, Room 15A-55, Rockville, MD 20857, USA.
N1 - Accession Number: 20013166935. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - The place of risk analysis in the international trade from a US perspective, through looking at the activities of the World Trade Organization and the Codex Alimentarius Commission is discussed. The used of risk analysis at the international level is also described and recommendations are made for strengthening international food safety initiatives.
KW - Codex Alimentarius
KW - food safety
KW - international trade
KW - law
KW - legislation
KW - risk assessment
KW - World Trade Organization
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - legal aspects
KW - legal principles
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - International Trade (EE600)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013166935&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food-borne Listeria monocytogenes risk assessment.
AU - Hitchins, A. D.
AU - Whiting, R. C.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2001///
VL - 18
IS - 12
SP - 1108
EP - 1117
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Hitchins, A. D.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20013166942. Publication Type: Journal Article; Conference paper. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition; Public Health
N2 - Listeria monocytogenes is ubiquitous in the environment and in food processing plants. Consequently, foods are frequently contaminated. However, the occurrence rate of listeriosis is only about five cases per million people per year. Listeriosis primarily strikes immunocompromised individuals, pregnant women and the elderly with a fatality rate of 20-25%. The FDA is in the process of finishing a risk assessment that is being conducted as an initial step in reviewing its approach to maximizing the public protection from foodborne L. monocytogenes. The risk assessment evaluated the presence and quantitative levels of L. monocytogenes in 21 groups of ready-to-eat foods. The potential growth of L. monocytogenes between retail point-of-sale, where contamination data originated, and consumption was modelled. The frequency and amount of consumption of these foods completed the data for the exposure assessment. For the hazard characterization or dose response part of the risk assessment, data from animal studies, virulence assays and epidemiological investigations were used to estimate the likelihood of illness for different human groups from consuming different numbers of L. monocytogenes. This risk assessment is a virtual review of current scientific knowledge. Quantitative modelling provides greater insight than a qualitative review and also indicates the uncertainty about our knowledge. The risk assessment does not attempt to define an acceptable or tolerable level of L. monocytogenes consumption or propose changes in regulations. These decisions are the responsibility of risk managers who consider additional factors such as food preferences, technical feasibility and societal values when evaluating regulatory policies.
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - listeriosis
KW - reviews
KW - risk assessment
KW - Listeria monocytogenes
KW - man
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - food contaminants
KW - listerellosis
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013166942&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotoxic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides - mechanisms leading to DNA adduct formation and tumorigenicity.
AU - Fu, P. P.
AU - Chou, M. W.
AU - Xia, Q.
AU - Yang, Y. C.
AU - Yan, J.
AU - Doerge, D. R.
AU - Chan, P. C.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2001///
VL - 19
IS - 2
SP - 353
EP - 385
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 1059-0501
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013178605. Publication Type: Journal Article. Language: English. Number of References: 165 ref. Registry Number: 9007-49-2. Subject Subsets: Grasslands & Forage; Veterinary Science; Weeds; Plant Breeding; Veterinary Science; Public Health; Tropical Diseases; Aromatic & Medicinal Plants; Agricultural Biotechnology
N2 - Plants that contain pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides, such as Senecio, Crotalaria and Heliotropium, are widely distributed in the world. These plants are probably the most common poisonous plants affecting livestock, wildlife and humans. Although pyrrolizidine alkaloids have been shown to be genotoxic, including tumourigenic in experimental animals, the mechanisms of tumour formation have not been fully understood. Our recent studies on riddelliine, riddelline N-oxide, and dehydroretronecine (DHR) provided evidence suggesting that pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides induce tumours via a genotoxic mechanism, and that tumourigenicity is mediated by a set of eight DHR-derived DNA adducts. This mechanism may be general to other carcinogenic pyrrolizidine alkaloids and may also be responsible for the other genotoxicities of pyrrolizidine alkaloids, including mutagenicity and teratogenicity. It is hypothesized that these DHR-derived DNA adducts are potential biomarkers of pyrrolizidine alkaloid tumourigenicity.
KW - DNA
KW - genotoxicity
KW - livestock
KW - neoplasms
KW - oxides
KW - poisonous plants
KW - pyrrolizidine alkaloids
KW - reviews
KW - Crotalaria
KW - Heliotropium
KW - man
KW - plants
KW - Senecio
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Boraginaceae
KW - Lamiales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Asteraceae
KW - Asterales
KW - Boraginales
KW - cancers
KW - carcinogenicity
KW - deoxyribonucleic acid
KW - toxic plants
KW - Plant Breeding and Genetics (FF020)
KW - Weeds and Noxious Plants (FF500)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013178605&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Data mining in the US Vaccine Adverse Event Reporting System (VAERS): early detection of intussusception and other events after rotavirus vaccination.
AU - Niu, M. T.
AU - Erwin, D. E.
AU - Braun, M. M.
JO - Vaccine
JF - Vaccine
Y1 - 2001///
VL - 19
IS - 32
SP - 4627
EP - 4634
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Niu, M. T.: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologic Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM-210, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20013137500. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - The Vaccine Adverse Event Reporting System (VAERS) is the US passive surveillance system monitoring vaccine safety. A major limitation of VAERS is the lack of denominator data (number of doses of administered vaccine), an element necessary for calculating reporting rates. Empirical Bayesian data mining, a data analysis method, utilizes the number of events reported for each vaccine and statistically screens the database for higher than expected vaccine-event combinations signaling a potential vaccine-associated event. This is the first study of data mining in VAERS designed to test the utility of this method to detect retrospectively a known side effect of vaccination-intussusception following rotavirus (RV) vaccine. Between October 1998 and December 1999, 112 cases of intussusception were reported. The data mining method was able to detect a signal for RV-intussusception in February 1999 when only four cases were reported. These results demonstrate the utility of data mining to detect significant vaccine-associated events at early date. Data mining appears to be an efficient and effective computer-based programme that may enhance early detection of adverse events in passive surveillance systems.
KW - adverse effects
KW - computer techniques
KW - data analysis
KW - human diseases
KW - immunization
KW - intussusception
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - computer applications
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013137500&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Iron and folate in fortified cereals.
AU - Whittaker, P.
AU - Tufaro, P. R.
AU - Rader, J. I.
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
Y1 - 2001///
VL - 20
IS - 3
SP - 247
EP - 254
CY - Clearwater; USA
PB - American College of Nutrition
SN - 0731-5724
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street SW, HFS-236, Washington, D.C. 20204, USA.
N1 - Accession Number: 20023015503. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 59-30-3, 7439-89-6. Subject Subsets: Human Nutrition
N2 - Objectives: Our objectives were to measure the iron and total folate contents in breakfast cereals, and to compare these values (assayed values) to labelled values for % Daily Value. We also determined by weight the amount of a ready-to-eat breakfast cereal that adults would eat and compared this to the labelled serving size, for which the reference amount for this cereal per eating occasion was 1 cup or 30 g. Design: 29 breakfast cereals were analysed for iron content using the bathophenanthroline reaction. 28 cereals were analysed for total folate utilizing a microbiological assay with tri-enzyme digestion. Serving size quantities were estimated in 72 adults who regularly ate breakfast cereal and were asked to fill a 16- or 22-cm round bowl with the amount of cereal that they would consume for breakfast. Results: When the labelled value was compared to the assayed value for iron content, 21 of the 29 breakfast cereals were 120% or more of the labelled value, and 8 cereals were 150% or more of the labelled value. Overall, analysed values for iron ranged from 80 to 190% of labelled values. Analysed values for folate ranged from 98 to 320% of labelled values. For 14 of 28 cereals, analysed values exceeded label declarations by more than 150%. Bran-containing cereals contained the highest amounts of folate relative to their label declarations. The median analysed serving size for the breakfast cereal was 47 g for females, 61 g for males with a combined median of 56 g as compared to the labelled value of 30 g. Conclusions: Analysed values of iron and folic acid in breakfast cereals were considerably higher than labelled values. For adults, the amount of cereal actually consumed was approximately 200% of the labelled serving size. When the quantity of cereal consumed is more than the labelled serving size and when the levels of iron and folate are higher than declared, the intake of both will be significantly greater than the labelled values. It will be important to continue monitoring serum ferritin and folate levels in NHANES IV, since daily consumption of breakfast cereals may contribute to the excessive intakes of iron and folate.
KW - bran
KW - breakfast cereals
KW - cereals
KW - folic acid
KW - food consumption
KW - food intake
KW - fortification
KW - iron
KW - nutritive value
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - folacin
KW - folate
KW - nutritional value
KW - quality for nutrition
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023015503&site=ehost-live&scope=site
UR - email: paul.whittaker@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of c-erbB-2 expression an activity in human ovariar carcinoma cells by hypericin.
AU - Hwang MyungSil
AU - Yum YoungNa
AU - Joo JongHo
AU - Kim Seyl
AU - Lee KookKyung
AU - Gee SungWan
AU - Kang HoIl
AU - Kim OkHee
JO - Anticancer Research
JF - Anticancer Research
Y1 - 2001///
VL - 21
IS - 4A
SP - 2649
EP - 2656
CY - Attiki; Greece
PB - International Institute of Anticancer Research
SN - 0250-7005
AD - Hwang MyungSil: National Institute of Toxicological Research, Korea Food and Drug Administration, Nokbun-Dong 5, Eunpyong-Gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20023137987. Publication Type: Journal Article. Language: English. Registry Number: 9026-43-1. Subject Subsets: Aromatic & Medicinal Plants; Public Health; Botanical Pesticides
N2 - The c-erbB-2 oncogene encodes a tyrosine kinase that constitutes the internal and transmembrane part of the epidermal growth factor receptor (EGFR). ErbB-2 overexpression has been reported in 20% to 30% of human adenocarcinomas of the breast and ovary, and has been linked to an unfavorable prognosis in patients. Hypericin is a protein tyrosine kinase inhibitor that has been exploited in models for anti-tumor and anti-viral activity. In this study, we investigated the effects of hypericin on the activity of the c-erbB-2 oncoprotein and its downstream kinases. We also investigated the effect of hypericin on metastasis. We used ovarian SK-OV-3 cells as a model to determine whether hypericin-induced cell death was associated with inhibition of c-erbB-2 expression and activation. The IC50 of hypericin after 72 hrs exposure was 7.5 µM as determined by the MTT assay. Apoptosis, which was assessed by morphological changes and a flow cytometric assay, was observed at 24 h after continuous exposure to 5 µM hypericin. Inhibition of expression of the c-erbB-2 protein was detected, using a monoclonal anti-erbB-2 antibody after 12-48 hrs of exposure to hypericin. Hypericin was found to inhibit autophosphorylation of the erbB-2 protein and downstream kinases such as MEK and ERK1/2. We also found up-regulation of p21WAF1 expression and down-regulation of Bcl-2 in hypericin treated cells. An invasion assay showed that hypericin inhibited the movement of SK-OV-3 cells into the Matrigel. However, gelatin zymography showed that hypericin had no effect on the secretion of matrix metalloproteinases (MMPs) in SK-OV-3 cells. From these results, we conclude that hypericin inhibits the growth of SK-OV-3 ovarian cancer cells, inhibits the autophosphorylation of c-erbB-2, induces apoptosis, and may inhibit invasion.
KW - adenocarcinoma
KW - antineoplastic properties
KW - antiviral properties
KW - apoptosis
KW - breast cancer
KW - carcinoma
KW - enzyme inhibitors
KW - gene expression
KW - kinases
KW - medicinal plants
KW - metalloproteinases
KW - metastasis
KW - neoplasms
KW - oncogenes
KW - ovarian cysts
KW - ovaries
KW - pharmacology
KW - protein kinase
KW - Hypericum
KW - man
KW - Clusiaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - anti-neoplastic properties
KW - anti-viral properties
KW - cancers
KW - drug plants
KW - hypericin
KW - medicinal herbs
KW - officinal plants
KW - tyrosine kinase
KW - Non-food/Non-feed Plant Products (SS200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023137987&site=ehost-live&scope=site
UR - email: hyunsung@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New generation tuberculosis vaccines.
AU - Collins, F. M.
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
Y1 - 2001///
VL - 23
IS - 3
SP - 17
EP - 23
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0196-4399
AD - Collins, F. M.: Laboratory of Mycobacterial Diseases, CBER, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20013023546. Publication Type: Journal Article. Language: English. Number of References: 47 ref.
N2 - This review of new generation tuberculosis vaccines discusses vaccination with live vs. dead vaccines, new vaccines for use in high incidence countries, experimental methods used in anti-tuberculous vaccine testing, new vaccines currently under development (live attenuated vaccines, whole-cell and subunit vaccines, immunotherapeutic vaccines and DNA vaccines) and regulatory issues associated with tuberculous vaccine development.
KW - human diseases
KW - immunization
KW - tuberculosis
KW - vaccination
KW - vaccine development
KW - vaccines
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - immune sensitization
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013023546&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of acute sensory-motor effects and test sensitivity using termiticide workers exposed to chlorpyrifos.
AU - Dick, R. B.
AU - Steenland, K.
AU - Krieg, E. F.
AU - Hines, C. J.
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
Y1 - 2001///
VL - 23
IS - 4
SP - 381
EP - 393
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0892-0362
AD - Dick, R. B.: Division of Applied Research and Technology, U.S. Department of Health and Human Services, Public Health Service/Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20023154219. Publication Type: Journal Article. Language: English. Registry Number: 2921-88-2. Subject Subsets: Public Health; Agricultural Entomology; Medical & Veterinary Entomology
N2 - Sensory and motor testing was performed on a group of termiticide workers primarily using chlorpyrifos-containing products to evaluate both the acute effects from current exposure and sensitivity of the measures to detect effects. The study group comprised 106 applicators and 52 nonexposed participants. Current exposure was measured by urinary concentrations of 3,5,6-trichloro-2-pyridinol (TCP) collected the morning of testing. The mean TCP value for the 106 applicators was 200 µg/g creatinine. Participants received 4-5 h of testing and were evaluated using a sensory-motor test battery recommended by a National Institute for Occupational Safety and Health (NIOSH)-sponsored advisory panel to be appropriate for testing effects from pesticide exposures. Measurements testing olfactory dysfunction, visual acuity, contrast sensitivity, colour vision, vibrotactile sensitivity, tremor, manual dexterity, eye-hand coordination, and postural stability were analysed. Study results indicated limited acute effects from exposure to chlorpyrifos using urinary TCP as a measure of current exposure. The effects occurred primarily on measures of postural sway in the eyes closed and soft-surface conditions, which suggests a possible subclinical effect involving the proprioceptive and vestibular systems. Several other tests of motor and sensory functions did not show any evidence of acute exposure effects, although statistically significant effects of urinary TCP on the Lanthony colour vision test scores and one contrast sensitivity test score were found. The visual measures, however, were not significant when a step-down Bonferroni correction was applied. Information also is presented on the sensitivity of the measures to detect effects in an occupationally exposed population using standard error of the parameter estimates.
KW - chlorpyrifos
KW - eyes
KW - motor skills
KW - nontarget effects
KW - nontarget organisms
KW - occupational disorders
KW - olfactory organs
KW - pesticides
KW - posture
KW - sensory disorders
KW - tremor
KW - urine
KW - vision disorders
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 3,5,6-trichloro-2-pyridinol
KW - chlorpyrifos-ethyl
KW - non-target organisms
KW - non-target species
KW - nontarget species
KW - visual impairments
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023154219&site=ehost-live&scope=site
UR - email: maudbay@wans.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in HIV-related inpatient admissions from 1993 to 1997: a seven-state study.
AU - Fleishman, J. A.
AU - Hellinger, F. J.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2001///
VL - 28
IS - 1
SP - 73
EP - 80
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Fleishman, J. A.: Agency for Healthcare Research and Quality, 2101 East Jefferson St., Rockville, MD 20852, USA.
N1 - Accession Number: 20023100800. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - Background and Objectives: Reports of declining HIV-related inpatient use have typically been based on limited or local data. Using comprehensive hospital discharge data from seven states (California, Colorado, Kansas, Maryland, New York, New Jersey, and South Carolina), this study examines trends in HIV-related inpatient admission rates and lengths of stay from 1993 through 1997. Methods: We identified HIV-related admissions by the International Classification of Diseases, ninth edition (ICD-9-CM) diagnosis codes in the range 042 to 044. Analyses assessed effects of state, gender, race/ethnicity, insurance, and time period; they also examined differential patterns of change. Results: HIV-related inpatient admission rates rose between 1993 and 1995 but began declining steadily starting in late 1995. This general pattern occurred for all states, demographic groups, and insurers. The magnitude of the decline varied; admissions for white males and for patients with private insurance showed the greatest decreases. Admission rates were highest for African-American males and lowest for white females. Lengths of stay declined steadily; trends did not differ by demographic group or payer. Conclusions: Results document the recent decline in HIV-related hospital admission rates. Relative declines in admissions parallel reported disparities in access to new antiretroviral therapies. Racial/ethnic disparities in inpatient use persist.
KW - acquired immune deficiency syndrome
KW - duration
KW - ethnic groups
KW - HIV infections
KW - hospitals
KW - human diseases
KW - human immunodeficiency viruses
KW - men
KW - sex differences
KW - trends
KW - whites
KW - women
KW - California
KW - Colorado
KW - Kansas
KW - Maryland
KW - New Jersey
KW - New York
KW - South Carolina
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Mountain States of USA
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Southeastern States of USA
KW - African-Americans
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - inpatient admissions
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023100800&site=ehost-live&scope=site
UR - email: jfleishm@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Induction of group 17 specific antibodies by pneumococcal type 17F and 17A polysaccharide vaccines.
AU - Frasch, C. E.
AU - Concepcion, N. F.
JO - Biologicals
JF - Biologicals
Y1 - 2001///
VL - 29
IS - 1
SP - 11
EP - 16
CY - London; UK
PB - Academic Press
SN - 1045-1056
AD - Frasch, C. E.: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA.
N1 - Accession Number: 20013114475. Publication Type: Journal Article. Language: English. Number of References: 15 ref.
N2 - The immunological cross-reactivity of two polysaccharides (PSs) was evaluated by examining pre- and post-immunization sera from adults who received either the Merck (17F) or Wyeth-Lederle (17A) vaccines to determine the immunological impact of the two different PSs in the vaccine. Results showed that when 17F or 17A was present in the vaccine, IgG antibodies were induced to both the 17A and 17F PSs. The homologous antibody responses for both vaccines were similar. Upon examination of the cross-reactive antibody between the two types, 70% of individuals that received the 17A and 75% of 17F vaccinees achieved more than 2.0 µg/ml of 17F IgG antibodies after vaccination. The serum from a vaccinee who received the Merck vaccine (17F) was equally inhibited by both 17F and 17A PSs, when the antigen on the plate was 17F or 17A, but there was no inhibition by the two non-group 17PSs. Similar results were found for the 17A induced antibodies in serum 89SF, a pool of sera from 17 individuals who received the the 17A PS vaccine. With the exception of two post-sera, antibodies induced by 17F were opsonic against both 17F and 17A strains. Antibodies induced by 17A PS were opsonic, except for one post serum, for both the 17F and 17A strains used in the opsonophagocytosis assay. It is concluded that a 23 valent pneumococcal vaccine containing either the type 17F or 17A PS can afford protection against invasive disease caused by either type 17F or 17A.
KW - antibodies
KW - antigens
KW - immunization
KW - immunology
KW - opsonins
KW - phagocytosis
KW - polysaccharides
KW - serum
KW - vaccination
KW - vaccines
KW - antigenicity
KW - complex carbohydrates
KW - immune sensitization
KW - immunogens
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013114475&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety data on meningococcal polysaccharide vaccine from the vaccine adverse event reporting system.
AU - Ball, R.
AU - Braun, M. M.
AU - Mootrey, G. T.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 32
IS - 9
SP - 1273
EP - 1280
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Ball, R.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, HFM-220, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20013157107. Publication Type: Journal Article. Corporate Author: USA, Vaccine Adverse Event Reporting System Working Group Language: English. Number of References: 30 ref.
N2 - Recent recommendations by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices may lead to the increased use of the meningococcal polysaccharide vaccine. The Vaccine Adverse Event Reporting System (VAERS) is useful for the detection of previously unrecognized reactions and for the monitoring of known reactions. Limitations of VAERS include underreporting and the inability to establish a causal relationship between vaccination and adverse events in most cases. From July 1990 through 31 October 1999, one hundred and ten adverse events were reported after receipt of meningococcal vaccine alone. 13 (12%) were serious, including 6 injection site reactions, 3 allergic reactions, 1 case of Guillain-Barré syndrome, and 3 miscellaneous events. Fever (30%), headache (17%), dizziness (15%), injection site hypersensitivity (13%), urticaria (12%), and paresthaesia (10%) were among the most common events reported. Fever and injection site and allergic reactions are most likely causally linked to the vaccine. That there were few reports of serious adverse events, with >6 million doses having been distributed, and no clear signal of a previously unrecognized serious reaction is reassuring with regard to the safety of meningococcal vaccine.
KW - adverse effects
KW - allergies
KW - Guillain-Barre syndrome
KW - human diseases
KW - hypersensitivity
KW - immunization
KW - meningitis
KW - paresis
KW - vaccination
KW - vaccine development
KW - vaccines
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - adverse reactions
KW - allergic responses
KW - bacterium
KW - hypersensitiveness
KW - immune sensitization
KW - Meningococcus
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013157107&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Counterpoint: alternative trial designs for antifungal drugs - time to talk.
AU - Powers, J. H.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 33
IS - 1
SP - 107
EP - 109
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Powers, J. H.: Division of Special Pathogen and Immunologic Drug Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, MD 20850, USA.
N1 - Accession Number: 20013116908. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - The problems encountered in historically controlled trials of antifungal agents, as alternatives to randomized controlled trials, are discussed. Suggestions in improving trial designs are given.
KW - antifungal agents
KW - drug development
KW - drug therapy
KW - medical research
KW - methodology
KW - mycoses
KW - randomized controlled trials
KW - chemotherapy
KW - fungistats
KW - methods
KW - Research (AA500)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013116908&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth of Escherichia coli O157:H7 during sprouting of alfalfa seeds.
AU - Stewart, D.
AU - Reineke, K.
AU - Ulaszek, J.
AU - Fu, T.
AU - Tortorello, M.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2001///
VL - 33
IS - 2
SP - 95
EP - 99
CY - Oxford; UK
PB - Blackwell Science
SN - 0266-8254
AD - Stewart, D.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20013119422. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - Escherichia coli O157:H7 was monitored daily during sprouting of lucerne seeds inoculated at high (3.92 log10 cfu g-1) and low (1.86 log10 cfu g-1) levels to assess the extent of pathogen growth during production. Sprouts and rinse water were tested by direct and membrane filter plating on modified sorbitol MacConkey agar and BCM O157:H7(+) agar; the antibody-direct epifluorescent filter technique; and rapid immunoassays. The pathogen reached maximum populations after one and two days of sprouting seeds inoculated at high and low levels, respectively; in either case, populations of 5-6 log10 cfu g-1 were reached. Detection limits of two rapid immunoassays, Reveal and VIP, without enrichment were determined to be 5-7 log10 cfu ml-1. These results show the ability of E. coli O157:H7 to grow to high levels during sprouting; however, because these levels may be below detection limits, it is necessary to include enrichment when monitoring sprout production for E. coli O157:H7 by the rapid test kits. The data indicate that sprouts may harbour high levels of pathogens. The appropriate use of rapid test methods for pathogen monitoring during sprouting is indicated.
KW - food contamination
KW - lucerne
KW - microbial contamination
KW - seeds
KW - sprouting
KW - sprouts
KW - Escherichia coli
KW - Medicago
KW - Medicago sativa
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Medicago
KW - alfalfa
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013119422&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prelicensure evaluation of combination vaccines.
AU - Goldenthal, K. L.
AU - Falk, L. A.
AU - Ball, L.
AU - Geber, A.
A2 - Breiman, R.
A2 - Goldenthal, K.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 33
SP - S267
EP - S273
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Goldenthal, K. L.: Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-475, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20023011876. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 49 ref. Subject Subsets: Public Health
KW - antigens
KW - bacterial diseases
KW - combined vaccines
KW - efficiency
KW - evaluation
KW - human diseases
KW - licences
KW - vaccine development
KW - viral diseases
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antigenicity
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immunogens
KW - licenses
KW - licensing
KW - mixed vaccines
KW - United States of America
KW - viral infections
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023011876&site=ehost-live&scope=site
UR - email: Goldenthal@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating the immune response to combination vaccines.
AU - Ball, L. K.
AU - Falk, L. A.
AU - Horne, A. D.
AU - Finn, T. M.
A2 - Breiman, R.
A2 - Goldenthal, K.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 33
SP - S299
EP - S305
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Ball, L. K.: Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 475, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20023011882. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 25 ref.
KW - bacterial diseases
KW - combined vaccines
KW - conjugate vaccines
KW - evaluation
KW - human diseases
KW - immune response
KW - immunization
KW - regulations
KW - vaccination
KW - Haemophilus influenzae type b
KW - Haemophilus influenzae
KW - Haemophilus
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - mixed vaccines
KW - rules
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023011882&site=ehost-live&scope=site
UR - email: BallL@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of studies to evaluate immune response to combination vaccines.
AU - Horne, A. D.
AU - Lachenbruch, P. A.
AU - Getson, P. R.
AU - Hsu, H. S.
A2 - Breiman, R.
A2 - Goldenthal, K.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 33
SP - S306
EP - S311
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Horne, A. D.: Vaccine and Blood Product Evaluation Branch, HFM-217, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20023011883. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 10 ref.
KW - combined vaccines
KW - evaluation
KW - immune response
KW - immunization
KW - statistical analysis
KW - vaccination
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - mixed vaccines
KW - statistical methods
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023011883&site=ehost-live&scope=site
UR - email: horne@cber.fda.gov\lachenbruch@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating the safety of combination vaccines.
AU - Ellenberg, S. S.
A2 - Breiman, R.
A2 - Goldenthal, K.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2001///
VL - 33
SP - S319
EP - S322
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Ellenberg, S. S.: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-210, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20023011886. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 16 ref.
KW - antigens
KW - combined vaccines
KW - human diseases
KW - immune response
KW - infectious diseases
KW - medical research
KW - methodology
KW - vaccine development
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - communicable diseases
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - methods
KW - mixed vaccines
KW - Research (AA500)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023011886&site=ehost-live&scope=site
UR - email: ellenberg@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Histopathology of experimental plague in cats.
AU - Watson, R. P.
AU - Blanchard, T. W.
AU - Mense, M. G.
AU - Gasper, P. W.
JO - Veterinary Pathology
JF - Veterinary Pathology
Y1 - 2001///
VL - 38
IS - 2
SP - 165
EP - 172
CY - Lawrence; USA
PB - American College of Veterinary Pathologists Inc
SN - 0300-9858
AD - Watson, R. P.: Department of Pathology, Avrum Gudelsky Center for Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
N1 - Accession Number: 20013086164. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science; Tropical Diseases
N2 - Formalin-fixed paraffin-embedded archival tissues of seven adult cats of both sexes that died after being experimentally infected with Yersinia pestis were examined using light microscopy to characterize the lesions. The cats were exposed in two groups using two routes of infection: ingestion of Y. pestis-infected rodent or subcutaneous injection of Y. pestis to simulate a flea bite. Immunohistochemistry was performed on tissues from all organ systems from a representative cat from each group to determine the distribution of Y. pestis bacilli during infection. In all seven cats, bubonic plague lesions were seen. The lesions of pneumonic plague were present in two cats. Septicaemic plague was confirmed in all seven cats by bacteriologic culture. Aggregations of bacteria were seen in lymphoid tissue in all cats and in lung tissues from the two cats with pneumonic plague. The most consistent histologic finding was necrosuppurative inflammation in the lymph nodes. Invariably, Y. pestis bacteria were present in large numbers at affected sites. Orally infected cats had more numerous lesions in the lymph nodes of the head and neck regions. These experimentally induced cases of feline plague document that cats are unique among carnivores in exhibiting bubonic, pneumonic, and septicaemic plague following exposure to Y. pestis. The lesions of the orally infected cats were consistent with those previously described for naturally occurring Y. pestis infections in cats and corroborate the contention that cats most commonly contract plague by eating Y. pestis-infected rodents and not via flea bite. The histopathology of Y. pestis disease in these cats is comparable to that described for human plague.
KW - experimental infection
KW - histopathology
KW - immunohistochemistry
KW - infection
KW - lungs
KW - lymph nodes
KW - plague
KW - zoonoses
KW - cats
KW - rodents
KW - Siphonaptera
KW - Yersinia pestis
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - experimental transmission
KW - zoonotic infections
KW - Pets and Companion Animals (LL070)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013086164&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic analysis for virulence factors in Escherichia coli O104:H21 that was implicated in an outbreak of hemorrhagic colitis.
AU - Feng, P.
AU - Weagant, S. D.
AU - Monday, S. R.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 1
SP - 24
EP - 28
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Feng, P.: Division of Microbiological Studies, Food and Drug Administration, HFS-516, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013010718. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Isolates of enterohaemorrhagic Escherichia coli (EHEC) of serotype O104:H21 implicated in a 1994 outbreak of haemorrhagic colitis in Montana were analysed for the presence of trait EHEC virulence markers. By using a multiplex PCR that specifically amplifies several genes, the O104:H21 strains were found to carry only the Shiga toxin 2 gene (stx2) and to express Stx2. They did not have the eaeA gene for γ-intimin, which is typically found in O157:H7, or the α- or β-intimin derivatives, which are common in other EHEC and enteropathogenic E. coli serotypes. Results of the multiplex PCR also indicated that the ehxA gene for enterohaemolysin was absent from O104:H21. This, however, was not consistent with the results of a phenotypic assay that showed them to be haemolytic or a PCR analysis with another set of ehxA-specific primers, which indicated the presence of ehxA. To resolve this discrepancy, the ehxA region in O104:H21 and O157:H7 strains, to which the multiplex PCR primers anneal, was cloned and sequenced. Comparison of the sequences showed that the upstream primer binding site in the ehxA gene of O104:H21 was not identical to that of O157:H7. Specifically, there were several base mutations, including an A-to-G substitution at the 3' end of the primer binding site. These base mutations are presumably not unique to O104:H21, since other enterohaemolytic serotypes were also not detected with the ehxA primers used in the multiplex PCR. Comparison of the ehxA sequences of O104:H21 strains with those of other Stx-producing E. coli strains showed that they more closely resembled those of O8:H19 strains, which have cluster II ehxA genes, than those of O157:H7 strains, which have cluster I ehxA sequences. By modifying the upstream ehxA primer, the multiplex PCR was able to detect ehxA genes in both O157:H7 and O104:H21 strains.
KW - genes
KW - haemorrhagic colitis
KW - human diseases
KW - mutations
KW - nucleotide sequences
KW - outbreaks
KW - virulence
KW - Montana
KW - USA
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - bacterium
KW - DNA sequences
KW - E. coli
KW - hemorrhagic colitis
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013010718&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - No evidence of infectious retroviruses in measles virus vaccines produced in chicken embryo cell cultures.
AU - Muhammad Shahabuddin
AU - Sears, J. F.
AU - Khan, A. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 2
SP - 675
EP - 684
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Muhammad Shahabuddin: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20013034179. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Poultry
N2 - All vaccines that are prepared in fowl embryo fibroblasts (CEFs) contain a low level of particle-associated reverse transcriptase (RT) activity, which is produced from the avian cell substrate. The RNAs present in the particles have sequence homology to viral DNAs belonging to the ancient endogenous avian virus (EAV) family or to the avian sarcoma-leukosis virus (ALV)-related subgroup E endogenous virus loci. Although no replication-competent retrovirus has been associated with the RT activity produced from CEFs, there have been some theoretical safety concerns regarding potential consequences of integration of EAV and ALV sequences in human DNA, which may result from nonproductive infection with replication-defective particles or infection with EAV and ALV pseudotypes bearing measles virus envelopes. To address these possibilities, we have analysed EAV and ALV particles in a measles virus vaccine equivalent (MVVE) preparation, obtained from a manufacturer in the USA, for integration and for replication in human peripheral blood mononuclear cells (PBMCs). The results show the absence of EAV and ALV integrants in DNA prepared from MVVE-inoculated human cells by direct DNA PCR and Alu PCR assays and no propagation of retrovirus in 18-day cultures of MVVE-inoculated human PBMCs by a highly sensitive PCR-based RT assay. These results provide further confidence regarding the safety of fowl RT activity in live viral vaccines and support the continued use of chick-cell-derived vaccines in humans.
KW - cell culture vaccines
KW - cell cultures
KW - embryos
KW - poultry
KW - vaccine development
KW - fowls
KW - measles virus
KW - Retroviridae
KW - Rous sarcoma virus
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - RNA Reverse Transcribing Viruses
KW - Alpharetrovirus
KW - Retroviridae
KW - chickens
KW - domesticated birds
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013034179&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of United States-licensed human immunodeficiency virus immunoassays for detection of group M viral variants.
AU - Koch, W. H.
AU - Sullivan, P. S.
AU - Roberts, C.
AU - Francis, K.
AU - Downing, R.
AU - Mastro, T. D.
AU - Nkengasong, J.
AU - Hu, D.
AU - Masciotra, S.
AU - Schable, C.
AU - Lal, R. B.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 3
SP - 1017
EP - 1020
CY - Washington; USA
PB - ASM Press, American Society for Microbiology
SN - 0095-1137
AD - Koch, W. H.: Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20013054085. Publication Type: Journal Article. Language: English. Number of References: 30 ref.
N2 - Six Food and Drug Administration (FDA)-licensed human immunodeficiency virus type 1 (HIV-1) and HIV-1/2 immunoassays, including 5 enzyme immunoassays and one rapid test, were challenged with up to 250 serum samples collected from 18 countries [date not given]. The serum samples were from individuals known to be infected with variants of HIV-1 including group M subtypes A, B, B′, C, D, E, F, and G and group O. All immunoassays detected the vast majority of samples tested. Three samples produced low signal over cutoff values in one or more tests: a clade B sample, an untypeable sample with a low antibody titre, and a group O sample. It is concluded that HIV-1 immunoassays used in the USA are capable of detecting most HIV-1 group M variants.
KW - diagnostic techniques
KW - enzyme immunoassay
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunodiagnosis
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - serological diagnosis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013054085&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assignment of CDC weak oxidizer group 2 (WO-2) to the genus Pandoraea and characterization of three new Pandoraea genomospecies.
AU - Daneshvar, M. I.
AU - Hollis, D. G.
AU - Steigerwalt, A. G.
AU - Whitney, A. M.
AU - Spangler, L.
AU - Douglas, M. P.
AU - Jordan, J. G.
AU - MacGregor, J. P.
AU - Hill, B. C.
AU - Tenover, F. C.
AU - Brenner, D. J.
AU - Weyant, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 5
SP - 1819
EP - 1826
CY - Washington; USA
PB - ASM Press, American Society for Microbiology
SN - 0095-1137
AD - Daneshvar, M. I.: Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Rd., Mailstop D11, Atlanta, GA 30333, USA.
N1 - Accession Number: 20013087688. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 37517-28-5, 39831-55-5, 69-52-3, 69-53-4, 7177-48-2, 1403-66-3, 1405-41-0, 32986-56-4, 49842-07-1. Subject Subsets: Public Health
N2 - CDC weak oxidizer group 2 (WO-2) consists of nine phenotypically similar human clinical isolates received by the Centers for Disease Control and Prevention (in Atlanta, Georgia, USA) between 1989 and 1998. Four of the isolates were from blood, three were from sputum, and one each was from bronchial fluid and maxillary sinus. All are aerobic nonfermentative, motile gram-negative rods with one to eight polar flagella per cell. All grew at 25 and 35°C and were positive for catalase, urease (usually delayed 3 to 7 days), citrate, alkalinization of litmus milk, oxidization of glycerol (weakly), and growth on MacConkey agar and in nutrient broth without NaCl. All except one strain were oxidase positive with the Kovács method, and all except one isolate weakly oxidized D-glucose. All were negative for oxidation of D-xylose, D-mannitol, lactose, sucrose, maltose, and 20 other carbohydrates, esculin hydrolysis, indole production, arginine dihydrolase, and lysine and ornithine decarboxylase. Only two of nine isolates reduced nitrate. Broth microdilution susceptibilities were determined for all strains against 13 antimicrobial agents. Most of the strains were resistant to ampicillin, extended-spectrum cephalosporins, and aminoglycosides, including gentamicin, tobramycin, and amikacin, but they varied in their susceptibility to fluoroquinolones. High-performance liquid chromatographic and mass spectrometric analyses of the WO-2 group identified ubiquinone-8 as the major quinone component. The percent G+C of the WO-2 strains ranged from 65.2 to 70.7% (thermal denaturation method). All shared a common cellular fatty acid (CFA) profile, which was characterized by relatively large amounts (7 to 22%) of 16:1ω7c, 16:0, 17:0cyc, 18:1ω7c, and 19:0cyc11-12; small amounts (1 to 3%) of 12:0 and 14:0; and eight hydroxy acids, 2-OH-12:0 (4%), 2-OH-14:0 (trace), 3-OH-14:0 (12%), 2-OH-16:1 (1%), 2-OH-16:0 (3%), 3-OH-16:0 (4%), 2-OH-18:1 (2%), and 2-OH-19:0cyc (3%). This profile is similar to the CFA profile of Pandoraea, a recently described genus associated with respiratory infections in cystic fibrosis patients. Sequencing of the 16S rRNA gene (1,300 bp) for all nine strains indicated a high level (≥98.8%) of homogeneity with Pandoraea spp. type strains. DNA-DNA hybridization analysis (hydroxyapatite method; 70°C) confirmed the identity of WO-2 with the genus Pandoraea and assigned three strains to Pandoraea apista and three to Pandoraea pnomenusa, and identified three additional new genomospecies containing one strain each (ATCC BAA-108, ATCC BAA-109, ATCC BAA-110). This study also shows that Pandoraea isolates may be encountered in blood cultures from patients without cystic fibrosis.
KW - amikacin
KW - aminoglycoside antibiotics
KW - ampicillin
KW - antibacterial agents
KW - bacterial diseases
KW - cephalosporins
KW - drug resistance
KW - gentamicin
KW - Gram negative bacteria
KW - human diseases
KW - quinolones
KW - susceptibility
KW - tobramycin
KW - Georgia
KW - USA
KW - Bacteria
KW - man
KW - Pandoraea
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Burkholderiaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multigenerational evaluation of sodium fluoride in rats.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Shackelford, M. E.
AU - Bryant, M. A.
AU - Olejnik, N.
AU - Ames, M. J.
AU - Rorie, J. I.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2001///
VL - 39
IS - 6
SP - 601
EP - 613
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20013074190. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7681-49-4. Subject Subsets: Human Nutrition
N2 - Since the mid 1940s, fluoride has been added to tap water in American communities in an effort to reduce the incidence of dental caries in the population. When the levels of fluoride in drinking water were tested and set, water was the only measurable source of fluoride for most communities. Now, adults and children ingest fluoride with foods and beverages prepared with fluoridated water, and they are exposed to fluoride-containing dental products. As a result, exposure to fluoride is greater than had been anticipated. In the early 1990s, the existing reproductive studies were reviewed in several reports and were considered to be inadequate to determine potential reproductive or developmental hazards. The effects of sodium fluoride ingestion at 0, 25, 100, 175 or 250 ppm in drinking water measured in rats throughout three generations are reported. Feed and fluid consumption, body weights and clinical signs were recorded at regular intervals. Decreased fluid consumption observed at 175 and 250 ppm was attributed to decreased palatability and did not affect reproduction. No cumulative effects were observed in the three generations. Mating, fertility and survival indices were not affected. Organ-to-body-weight ratios and organ-to-brain weight ratios were not affected. Sodium fluoride up to 250 ppm did not affect reproduction in rats.
KW - drinking water
KW - fertility
KW - intake
KW - laboratory animals
KW - sodium fluoride
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013074190&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotyping Encephalitozoon hellem isolates by analysis of the polar tube protein gene.
AU - Xiao LiHua
AU - Li LiXia
AU - Moura, H.
AU - Sulaiman, I.
AU - Lal, A. A.
AU - Gatti, S.
AU - Scaglia, M.
AU - Didier, E. S.
AU - Visvesvara, G. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 6
SP - 2191
EP - 2196
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Xiao LiHua: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Building 22, Mail Stop F-12, 4770 Buford Highway, Atlanta, GA 30341, USA.
N1 - Accession Number: 20013095122. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology
N2 - To develop an alternative genotyping tool, the genetic diversity of Encephalitozoon hellem was examined at the polar tube protein (PTP) locus. Nucleotide sequence analysis of the PTP gene divided 24 E. hellem isolates from patients in different parts of the world into four genotypes, compared to two genotypes identified by analysis of the internal transcribed spacer of the rRNA gene. The four PTP genotypes differed from each other by the copy number of the 60-bp central repeat as well as by point mutations. A simple PCR test was developed to differentiate E. hellem genotypes based on the difference in the size of PTP PCR products, which should facilitate the genotyping of E. hellem in clinical samples.
KW - genes
KW - genetic diversity
KW - genotypes
KW - human diseases
KW - mutations
KW - polymerase chain reaction
KW - ribosomal RNA
KW - Encephalitozoon hellem
KW - man
KW - Encephalitozoon
KW - Encephalitozoonidae
KW - Microspora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - PCR
KW - rRNA
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013095122&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences.
AU - Xiao LiHua
AU - Li LiXia
AU - Visvesvara, G. S.
AU - Moura, H.
AU - Didier, E. S.
AU - Lal, A. A.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 6
SP - 2248
EP - 2253
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Xiao LiHua: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Building 22, Mail Stop F-12, 4770, Buford Highway, Atlanta, GA 30341, USA.
N1 - Accession Number: 20013095141. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Protozoology
N2 - Encephalitozoon cuniculi infects a wide range of mammalian hosts. Three genotypes based on the number of GTTT repeats in the internal transcribed spacer (ITS) of the rRNA have been described, of which genotypes I and III have been identified in humans. In this study, the genetic diversity of E. cuniculi was examined at the polar tube protein (PTP) and spore wall protein I (SWP-1) loci. Nucleotide sequence analysis of the PTP gene divided 11 E. cuniculi isolates into three genotypes in congruence with the result of analysis of the ITS of the rRNA gene. The three PTP genotypes differed from one another by the copy number of the 78-bp central repeat as well as point mutations. These E. cuniculi isolates also differed from one another in the number of 15- and 36-bp repeats in the SWP-1 gene. In addition, some E. cuniculi isolates had heterogeneous copies of the SWP-1 gene with various numbers of repeats. Intragenotypic variation was also observed at the SWP-1 locus. Based on the length polymorphism and sequence diversities of the PTP and SWP-1 genes, two simple PCR tests were developed to differentiate E. cuniculi in clinical samples.
KW - genes
KW - genotypes
KW - nucleotide sequences
KW - repetitive DNA
KW - Encephalitozoon cuniculi
KW - Encephalitozoon
KW - Encephalitozoonidae
KW - Microspora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013095141&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developmental toxicity of sodium fluoride measured during multiple generations.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Shackelford, M. E.
AU - Olejnik, N.
AU - Ames, M. J.
AU - Rorie, J. I.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2001///
VL - 39
IS - 8
SP - 867
EP - 876
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20013098797. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7681-49-4. Subject Subsets: Human Nutrition
N2 - Sodium fluoride (NaF) has been used to fluoridate drinking water in the USA since the mid 1940s. Because of the lack of reliable studies on the multigeneration effects of the compound, NaF (0, 25, 100, 175 or 250 ppm in drinking water) was given to rats continuously during three generations. Parental (F0) generation rats were treated for 10 weeks and mated within groups. At gestation day 20, caesarean sections were performed and eight F0 females per group and their litters (F1) were observed for implant status, fetal weight and length, sex and morphological development. The remaining F0 females (29-32 per group) were allowed to litter. F1 offspring (36 of each sex per group) were mated within groups, and caesarean sections were performed at gestation day 20. The F1 females and their litters (F2) were observed for implant status, fetal weight and length, sex and morphological development. In addition, F2 fetuses were evaluated for internal (soft-tissue) and skeletal development. Decreased fluid consumption for F0 and F1 dams at 175 and 250 ppm was attributed to decreased palatability of the solution. No dose-related effects in feed consumption or mean body weight gain were observed in either F0 or F1 females. Numbers of corpora lutea, implants, viable fetuses and fetal morphological development were similar in all groups. No dose-related anomalies in internal organs were observed in F2 fetuses. Ossification of the hyoid bone of F2 fetuses was significantly decreased at 250 ppm. Because of the decreased ossification of the hyoid bone, 250 ppm is considered the level which may cause developmental toxicity.
KW - biological development
KW - bones
KW - corpus luteum
KW - fetus
KW - generations
KW - laboratory animals
KW - length
KW - ossification
KW - sodium fluoride
KW - teratogenesis
KW - teratogens
KW - toxicity
KW - weight
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - foetus
KW - hyoid bone
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013098797&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors.
AU - Piesman, J.
AU - Schneider, B. S.
AU - Zeidner, N. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 11
SP - 4145
EP - 4148
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Piesman, J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013171965. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - Quantitative real-time PCR was used to assay spirochaetes (Borrelia burgdorferi) in feeding ticks (Ixodes scapularis). Flat nymphal ticks were allowed to feed ad libitum on out-bred mice. Spirochaetes in tick midguts increased sixfold, from 998 per tick before attachment to 5884 at 48 h of attachment. Spirochaetes in tick salivary glands increased >17-fold, from 1.2 per salivary gland pair before feeding to 20.8 at 72 h post-attachment. The period of the most rapid increase in the number of spirochaetes in the salivary glands occurred from 48 to 60 h post-attachment; this time period coincides with the maximal increase in transmission risk during nymphal tick feeding.
KW - disease transmission
KW - disease vectors
KW - host parasite relationships
KW - methodology
KW - midgut
KW - polymerase chain reaction
KW - salivary glands
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - mice
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - bacterium
KW - methods
KW - parasite host relationships
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013171965&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cellular fatty acid composition of Lautropia mirabilis.
AU - Daneshvar, M. I.
AU - Douglas, M. P.
AU - Weyant, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 11
SP - 4160
EP - 4162
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Daneshvar, M. I.: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Rd., N.E., Mailstop D11, Atlanta, GA 30333, USA.
N1 - Accession Number: 20013171968. Publication Type: Journal Article. Language: English. Number of References: 5 ref.
N2 - Ten strains of Lautropia mirabilis (ATCC 51599T and nine phenotypically similar clinical isolates) were examined for cellular fatty acid (CFA) composition to evaluate their chemical relatedness to known bacterial species and groups. The CFAs were liberated from whole cells by base hydrolysis, methylated, and analysed by gas-liquid chromatography. CFA profiles were generated by using a commercial software package (MIDI). All strains tested had an identical CFA profile characterized by major amounts of 16:1ω7c (41%) and 16:0 (44%); smaller amounts (1 to 4%) of 3-OH-10:0, 12:0, 14:0, 15:0, and 18:1ω7c; trace amounts (<1%) of 10:0, 18:2 and 18:0; and no cyclopropane acids. This profile was similar to the CFA profiles of Acidovorax delafieldii, Comamonas terrigena, and strains of an unclassified Centers for Disease Control group designated weak oxidizer group 1. CFA analysis, when supplemented by phenotypic characterization, is useful for the identification of L. mirabilis isolates.
KW - chemical composition
KW - fatty acids
KW - Gram negative bacteria
KW - human diseases
KW - strains
KW - taxonomy
KW - Acidovorax
KW - Acidovorax delafieldii
KW - Bacteria
KW - Comamonas
KW - Comamonas terrigena
KW - Gracilicutes
KW - Lautropia mirabilis
KW - man
KW - Bacteria
KW - prokaryotes
KW - Comamonadaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Acidovorax
KW - Comamonas
KW - Lautropia
KW - Burkholderiaceae
KW - bacterium
KW - systematics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013171968&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nucleic acid sequence-based amplification assays for rapid detection of West Nile and St. Louis encephalitis viruses.
AU - Lanciotti, R. S.
AU - Kerst, A. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2001///
VL - 39
IS - 12
SP - 4506
EP - 4513
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Lanciotti, R. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampart Rd., Fort Collins, CO 80521, USA.
N1 - Accession Number: 20023007947. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The development and application of nucleic acid sequence-based amplification (NASBA) assays for the detection of West Nile (WN) and St. Louis encephalitis (SLE) viruses are reported. Two unique detection formats were developed for the NASBA assays: a postamplification detection step with a virus-specific internal capture probe and electrochemiluminescence (NASBA-ECL assay) and a real-time assay with 6-carboxyfluorescein-labelled virus-specific molecular beacon probes (NASBA-beacon assay). The sensitivities and specificities of these NASBA assays were compared to those of a newly described standard reverse transcription (RT)-PCR and TaqMan assays for SLE virus and to a previously published TaqMan assay for WN virus. The NASBA assays demonstrated exceptional sensitivities and specificities compared to those of virus isolation, the TaqMan assays, and standard RT-PCR, with the NASBA-beacon assay yielding results in <1 h. These assays should be of utility in the diagnostic laboratory to complement existing diagnostic testing methodologies and as a tool in conducting flavivirus surveillance in the United States.
KW - analytical methods
KW - assays
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - nucleotide sequences
KW - polymerase chain reaction
KW - rapid methods
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - West Nile virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - analytical techniques
KW - DNA sequences
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023007947&site=ehost-live&scope=site
UR - email: rsl2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the effectiveness of educational interventions in the Pennsylvania Central Region Farm Safety Pilot Project.
AU - Landsittel, D. P.
AU - Murphy, D. J.
AU - Kiernan, N. E.
AU - Hard, D. L.
AU - Kassab, C.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2001///
VL - 40
IS - 2
SP - 145
EP - 152
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Landsittel, D. P.: Division of Safety Research, Analysis and Field Evaluations Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S L4020, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023063633. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - Backgound: Evaluation of agricultural safety interventions has frequently been identified as an area requiring further research. This study prospectively evaluates the effectiveness of three specific educational safety interventions in reducing farm hazards. Methods: Farm characteristics and hazard conditions at 216 farms in Pennsylvania, USA were assessed through a questionnaire and objective audit, respectively, at both pre- and post-intervention time points. Counties were assigned to one of the following interventions: youth education, community coalition, self-audit, pre/post control, or post-only control group. Changes in hazard were analysed through linear regression. Results: Self-audit was the most effective intervention, leading to a 20% reduction in hazard scores. The community coalition and pre/post control group also showed reductions. Conclusions: Intervention effectiveness significantly differs depending on initial hazards, indicating the need to target specific interventions for more or less hazardous farms. Findings of this prospective evaluation differ from the initial cross-sectional results, thus underscoring the need for longitudinal investigations.
KW - agriculture
KW - education programmes
KW - farm workers
KW - farms
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - Pennsylvania
KW - USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - educational programs
KW - occupational safety
KW - United States of America
KW - Education and Training (CC100)
KW - Agricultural Economics (EE110)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063633&site=ehost-live&scope=site
UR - email: del6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Is it safe on deck? Fatal and non-fatal workplace injuries among Alaskan commercial fishermen.
AU - Thomas, T. K.
AU - Lincoln, J. M.
AU - Husberg, B. J.
AU - Conway, G. A.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2001///
VL - 40
IS - 6
SP - 693
EP - 702
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Thomas, T. K.: Alaska Field Station, Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4230 University Drive, Suite 310, Anchorage, AK 99508, USA.
N1 - Accession Number: 20023132509. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Commercial fishing in Alaska accounts for an occupational fatality rate that is 28 times the rate for all U.S. workers. Most deaths are attributed to vessel sinking or capsizing. However, many deaths and most non-fatal injuries are not related to vessel loss. This paper describes injuries that occur on the dock or on the fishing vessel. Methods: Data from fishing fatalities and non-fatal injuries between 1991-1998 were analyzed using the Alaska Occupational Injury Surveillance System and the Alaska Trauma Registry. Results There were 60 workplace deaths unrelated to vessel loss; most from falls overboard, others from trauma caused by equipment on deck. There were 574 hospitalized injuries, often from falls on deck, entanglement in machinery, or being struck by an object. Summary: Fishing boats are hazardous working environments. Further efforts are required to prevent falls overboard and on deck, and to redesign or install safety features on fishing machinery and equipment.
KW - boats
KW - fishermen
KW - mortality
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - trauma
KW - work places
KW - Alaska
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - occupational safety
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023132509&site=ehost-live&scope=site
UR - email: Jlincoln@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preinitiation treatment of indole-3-carbinol (I3C) inhibits 7,12-dimethylbenz[α]anthracene (DMBA)-induced rat mammary carcinogenesis.
AU - Kang JinSeok
AU - Ahn Byeongwoo
AU - Nam KiTaek
AU - Choi Mina
AU - Kim JiYoung
AU - Kim DaeJoong
AU - Jang DongDeuk
AU - Yang KiHwa
JO - Korean Journal of Veterinary Research
JF - Korean Journal of Veterinary Research
Y1 - 2001///
VL - 41
IS - 4
SP - 549
EP - 555
CY - Daejon; Korea Republic
PB - Korean Society of Veterinary Science
SN - 1225-0198
AD - Kang JinSeok: National Institute of Toxicology Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20023061134. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 42 ref. Registry Number: 700-06-1. Subject Subsets: Dairy Science; Human Nutrition
N2 - Indole-3-carbinol (I3C), one component of cruciferous vegetables (Family Cruciferae [Brassicaceae]), has been shown to exert its chemopreventive effect in the liver, colon and mammary tissue before or during concurrent exposure to carcinogens. However, numerous evidences have shown that consumption of I3C induced tumour development in some tissues. The following study investigated the modifying effects of I3C in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary gland tumour rat model. 52 female Sprague-Dawley rats were randomly divided into 5 groups. Animals of group I were given the diet containing 100 ppm I3C, and animals of groups II and IV were given the diet containing 300 ppm I3C from 6 weeks of age. At 7 weeks of age, the animals of groups I, II and III were intubated with DMBA. All animals were killed at 20 weeks after carcinogen treatment. There were significant increases in food consumption in I3C feeding groups compared with those of the basal diet feeding groups. The incidences of mammary tumours in groups I, II and III were 75.0 (9/12), 56.3 (9/16) and 93.8% (15/16), respectively, and the average number of tumours of group I (DMBA+I3C 100 ppm: 2.08±0.61) and II (DMBA+I3C 300 ppm: 1.19±0.32) were significantly lower than that of group III (DMBA alone: 4.63±0.72) at P<0.05 and 0.001, respectively. On the basis of pathological examination, most of the appearing tumours were identified as adenocarcinomas. Many tumour epithelial cells showed strong oestrogen receptor (ER) α expression, but there were slight differences of ERαexpression among the types of tumours. It is suggested that preinitiation treatment of I3C has an inhibitory effect on mammary carcinogenesis induced by DMBA.
KW - adenocarcinoma
KW - animal models
KW - breast cancer
KW - carcinogenesis
KW - disease models
KW - disease prevention
KW - food consumption
KW - human diseases
KW - indole-3-methanol
KW - mammary gland neoplasms
KW - medicinal properties
KW - neoplasms
KW - oestrogen receptors
KW - preventive nutrition
KW - vegetables
KW - Brassicaceae
KW - man
KW - rats
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Muridae
KW - rodents
KW - cancers
KW - Capparales
KW - estrogen receptors
KW - indole-3-carbinol
KW - mammary tumour
KW - vegetable crops
KW - Non-food/Non-feed Plant Products (SS200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023061134&site=ehost-live&scope=site
UR - email: kangjins@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of veterinary medicine in public health: antibiotic use in food animals and humans and the effect on evolution of antibacterial resistance.
AU - Lathers, C. M.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2001///
VL - 41
IS - 6
SP - 595
EP - 599
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 0091-2700
AD - Lathers, C. M.: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, U.S. Food and Drug Administration (FDA), Room 390, HFV-100, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20023028421. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 11006-76-1, 120138-50-3. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - The role of veterinary medicine in the promotion of public health, specifically in monitoring the use of antibiotics in food animals and the effects of these uses in the evolution of antibacterial resistance, are discussed. An interagency task force, formed to monitor antimicrobial resistance in the USA, is described. Also, the use of quantitative risk assessments, as tools to assess potential risks to humans of antibiotic use in food animals and to develop microbial safety policies for the protection of the public health, are described. Presented in the paper are the quantitative risk assessments of the human health impact of Campylobacter resistance against quinolone that is associated with poultry meat consumption, and of the impact of virginiamycin resistance of Enterococcus faecium in animals as opposed to treating E. faecium infection in man with synercid (quinupristin and dalfopristin).
KW - antibacterial agents
KW - antibiotics
KW - drug resistance
KW - food
KW - food safety
KW - human diseases
KW - livestock
KW - monitoring
KW - public health
KW - quinupristin
KW - risk assessment
KW - veterinary medicine
KW - virginiamycin
KW - USA
KW - Campylobacter
KW - Enterococcus faecium
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - dalfopristin
KW - fluoroquinolone
KW - surveillance systems
KW - synercid
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Animal Husbandry and Production (LL180) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023028421&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A rapid method for determining the tuberculocidal activity of liquid chemical germicides.
AU - Erickson, B. D.
AU - Campbell, W. L.
AU - Cerniglia, C. E.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 2001///
VL - 43
IS - 2
SP - 79
EP - 82
CY - New York; USA
PB - Springer-Verlag New York Inc.
SN - 0343-8651
AD - Erickson, B. D.: Division of Microbiology, National Center for Toxicological Research, HFT-250, 3900 NCTR Rd., U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013116831. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 111-30-8.
KW - assays
KW - disinfectants
KW - glutaraldehyde
KW - luciferases
KW - Mycobacterium bovis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - germicidal capacity
KW - luciferase
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013116831&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quadrupole ion storage tandem mass spectrometry and high-resolution mass spectrometry: complementary application in the measurement of 2,3,7,8-chlorine substituted dibenzo-p-dioxins and dibenzofurans in US foods.
AU - Hayward, D. G.
AU - Holcomb, J.
AU - Glidden, R.
AU - Wilson, P.
AU - Harris, M.
AU - Spencer, V.
A2 - Birnbaum, L. S.
A2 - Fiedler, H.
A2 - Goldman, L.
A2 - Hutzinger, O.
A2 - Matthies, M.
A2 - Needham, L. L.
A2 - Patterson Jr., D. G.
A2 - Rappe, C.
A2 - Safe, S. H.
JO - Chemosphere
JF - Chemosphere
Y1 - 2001///
VL - 43
IS - 4/7
SP - 407
EP - 415
CY - Oxford; UK
PB - Pergamon Press
SN - 0045-6535
AD - Hayward, D. G.: US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20013066331. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 17 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - The US Food and Drug Administration has simultaneously utilized both high-resolution mass spectrometry (HRMS) and quadrupole ion storage tandem mass spectrometry (QISTMS) in the measurement of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) in 147 food samples collected in 1998 and 1999 in the US. In 1998, 20 egg samples, six scallop, 10 blue crab, eight American lobster, 10 pollack, 15 striped bass, five rockfish, 10 crawfish, seven aquacultured and 13 wild-caught salmon, along with 19 cream and 18 mozzarella cheese samples were measured for PCDD/Fs. QISTMS provided limits of detection (LODs) close to those produced using HRMS for many congeners in 56 samples analysed by both techniques in 1998 and three salmon and three striped bass collected in 1999. The I-TEQs of the mean levels for measured congeners in 40 samples of fish and shellfish and 16 cheese and eggs from 1998 analysed by HRMS and QISTMS were 0.99 and 1.1 ng/kg wet weight, respectively. The I-TEQ for mean congener levels in the 40 fish and shellfish measured by HRMS was 1.4 ng/kg wet weight. A higher sample throughput with greater data quality at a lower cost is achievable by using both QISTMS and HRMS.
KW - crayfish
KW - food
KW - food contamination
KW - food safety
KW - mass spectrometry
KW - polychlorinated dibenzodioxins
KW - polychlorinated dibenzofurans
KW - quantitative techniques
KW - screening
KW - USA
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - screening tests
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013066331&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation of dietary supplements in the United States: understanding the Dietary Supplement Health and Education Act.
AU - Hoffman, F. A.
JO - Clinical Obstetrics and Gynecology
JF - Clinical Obstetrics and Gynecology
Y1 - 2001///
VL - 44
IS - 4
SP - 780
EP - 788
CY - Philadelphia; USA
PB - Lippincott Williams & Wilkins
SN - 0009-9201
AD - Hoffman, F. A.: United States Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20023131827. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - In this article, an overview on the regulation of dietary supplements in the USA is provided, based on the guidelines set by the Dietary Supplement Health and Education Act. Issues on labelling requirements, quality control and manufacturing, health claims, safety and efficacy, risks and benefits, and reporting adverse effects are discussed. Also, the role of the physician in information campaigns regarding the health benefits of these products is addressed.
KW - adverse effects
KW - food supplements
KW - guidelines
KW - labelling
KW - quality controls
KW - regulations
KW - risk assessment
KW - safety
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - labeling
KW - labels
KW - quality assurance
KW - recommendations
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Marketing and Distribution (EE700)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023131827&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of new vaccines against dengue fever and Japanese encephalitis.
AU - Kinney, R. M.
AU - Huang, C. Y. H.
T3 - Recent developments in antiviral vaccines
JO - Intervirology
JF - Intervirology
Y1 - 2001///
VL - 44
IS - 2/3
SP - 176
EP - 197
CY - Basel; Switzerland
PB - S Karger AG
SN - 0300-5526
AD - Kinney, R. M.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013114854. Publication Type: Journal Article. Note: Recent developments in antiviral vaccines Language: English. Number of References: 60 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Tropical Diseases
N2 - Mosquito-borne dengue (DEN) and Japanese encephalitis (JE) viruses are the leading causes of arthropod-transmitted viral disease in humans. A licensed tetravalent vaccine that provides effective, long-term immunity against all four serotypes of DEN virus is needed, but is currently unavailable. Improvements to currently available JE vaccines are also needed. Past and recent strategies for the development of new DEN and JE vaccines include inactivated and live attenuated viruses, engineered viruses and chimeric viruses derived from infectious cDNA clones of DEN or JE virus, recombinant pox-viruses, recombinant baculoviruses, protein expression in Escherichia coli and naked DNA vaccines. This report summarizes some of the recent developments in DEN and JE vaccinology, particularly vaccine strategies that involve live attenuated viruses, engineered viruses derived from infectious cDNA clones and naked DNA vaccines.
KW - complementary DNA
KW - dengue haemorrhagic fever
KW - DNA vaccines
KW - human diseases
KW - inactivated vaccines
KW - Japanese encephalitis
KW - live vaccines
KW - recombinant antigens
KW - recombinant vaccines
KW - reviews
KW - vaccine development
KW - vaccines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - attenuated vaccines
KW - cDNA
KW - dengue hemorrhagic fever
KW - killed vaccines
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variation within the vat(E) allele of Enterococcus faecium isolates from retail poultry samples.
AU - Simjee, S.
AU - McDermott, P. F.
AU - Wagner, D. D.
AU - White, D. G.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2001///
VL - 45
IS - 10
SP - 2931
EP - 2932
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Simjee, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20013147797. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Veterinary Science; Veterinary Science; Poultry
N2 - In a survey of retail meat samples, 12 quinupristin-dalfopristin-resistant (MICs, ≥4 mg/litre) E. faecium isolates that carried a vat(E) gene were recovered. DNA sequence comparison revealed five new variations in the vat(E) allele among 12 isolates, which were designated vat(E-4) through vat(E-8); two isolates had vat(E-1). There was no correlation between the number of base changes and the quinupristin-dalfopristin MIC. The sequences determined in this study have been deposited in GenBank under accession numbers AY043211 (vat (E-4)), AY043209 (vat (E-5)), AY043210 (vat (E-6)), AY043212 (vat (E-7)) and AY043213 (vat (E-8)).
KW - alleles
KW - amino acid sequences
KW - antibacterial agents
KW - drug resistance
KW - genes
KW - genetic variation
KW - nucleotide sequences
KW - poultry meat
KW - Enterococcus faecium
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - dalfopristin
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - protein sequences
KW - quinuprisitin
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and expression of cephamycinase blaCMY genes in Escherichia coli and Salmonella isolates from food animals and ground meat.
AU - Zhao, S.
AU - White, D. G.
AU - McDermott, P. F.
AU - Friedman, S.
AU - English, L.
AU - Ayers, S.
AU - Meng, J.
AU - Maurer, J. J.
AU - Holland, R.
AU - Walker, R. D.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2001///
VL - 45
IS - 12
SP - 3647
EP - 3650
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20013172905. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 58-71-9, 153-61-7, 33564-30-6, 35607-66-0, 80370-57-6, 73384-59-5, 74578-69-1, 58001-44-8. Subject Subsets: Poultry
N2 - 21 Salmonella and 54 Escherichia coli isolates, recovered from food animals and retail ground meats, that exhibited decreased susceptibilities to ceftiofur and ceftriaxone were shown to possess a blaCMY gene. The blaCMY-4 gene was identified in an E. coli isolate recovered from retail chicken and was further shown to be responsible for resistance to cefalotin, ampicillin, and amoxicillin-clavulanic acid, and elevated MICs of ceftriaxone, cefoxitin and ceftiofur. The sequence of the retail meat E. coli blaCMA-4 gene has been assigned GenBank accession number AF420597.
KW - amoxicillin
KW - ampicillin
KW - antibacterial agents
KW - cefalotin
KW - cefoxitin
KW - ceftiofur
KW - ceftriaxone
KW - chicken meat
KW - clavulanic acid
KW - drug susceptibility
KW - food contamination
KW - genes
KW - meat
KW - meat products
KW - molecular genetics
KW - multiple drug resistance
KW - nucleotide sequences
KW - poultry
KW - resistance mechanisms
KW - Escherichia coli
KW - fowls
KW - Salmonella
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - amoxycillin
KW - bacterium
KW - biochemical genetics
KW - cephalothin
KW - chickens
KW - DNA sequences
KW - domesticated birds
KW - E. coli
KW - food contaminants
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Scanning electron microscopy determination of string mozzarella cheese in gastric contents.
AU - Platek, S. F.
AU - Crowe, J. B.
AU - Ranieri, N.
AU - Wolnik, K. A.
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
Y1 - 2001///
VL - 46
IS - 1
SP - 131
EP - 134
CY - West Conshohocken; USA
PB - American Society for Testing and Materials (ASTM)
SN - 0022-1198
AD - Platek, S. F.: Inorganic Branch, Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, Ohio, USA.
N1 - Accession Number: 20023063492. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Entomology; Dairy Science
N2 - As part of a suspected homicide investigation, a sampling of the gastric contents from the victim was forwarded to the U.S. Food and Drug Administration's Forensic Chemistry Center (FCC) for analysis of specific, selected components. The victim was known to have consumed string mozzarella cheese, as a snack, less than 24 h before his disappearance and the subsequent discovery of the body. The investigation sought to confirm or dismiss speculation the victim may have been fed a meal or eaten additional food prior to his death. Analysis of the stomach contents involved examination by stereoscopic light microscopy (SLM) and isolation, processing, and analysis of suspect materials by scanning electron microscopy (SEM). Several wax-like, off-white to cream-coloured objects were noted by SLM examination and removed from the gastric contents. Through a series of fixation, sectioning, drying, and coating steps, these objects were prepared for analysis by SEM. Comparison of the suspect material with laboratory control string mozzarella cheese showed excellent correlation between the analysed samples, confirming the suspect material from the stomach contents as string mozzarella cheese.
KW - analytical methods
KW - cheesemaking
KW - forensic entomology
KW - forensic medicine
KW - Mozzarella cheese
KW - postmortem examinations
KW - scanning electron microscopy
KW - stomach
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - autopsy
KW - cheese making
KW - postmortem inspections
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Forensic Science (ZZ700)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Subchronic toxicity of fish oil concentrates in male and female rats.
AU - Rabbani, P. I.
AU - Alam, H. Z.
AU - Chirtel, S. J.
AU - Duvall, R. E.
AU - Jackson, R. C.
AU - Ruffin, G.
JO - Journal of Nutritional Science and Vitaminology
JF - Journal of Nutritional Science and Vitaminology
Y1 - 2001///
VL - 47
IS - 3
SP - 201
EP - 212
CY - Tokyo; Japan
PB - Center for Academic Publications Japan
SN - 0301-4800
AD - Rabbani, P. I.: Risk Assessment, HFS-308, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 20013112411. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Registry Number: 57-88-5, 7439-89-6, 1406-18-4. Subject Subsets: Maize; Human Nutrition
N2 - There are an overwhelming number of reports indicating the beneficial effects of fish oil supplements in human and animal nutrition. The purpose of this study, 2nd in a series, was to evaluate the effects, particularly those that may be harmful, of high-dose, long-term consumption of fish oil concentrates (FOC) using male and female rats. 120 male and 120 female rats were gavaged daily with oils and oil mixtures in a volume equal to 0.5% body weight (5 ml/kg/day) for 13 weeks. The administered oils were corn oil, pure menhaden oil (MO), pure MaxEPA fish oil or different mixtures of corn oil with MO. The stability and the homogeneity of the dosing solutions were tested under study conditions. The animals received isocaloric and isonitrogenous diets throughout. Food and pure water were supplied ad libitum. At the end of the in-life phase of the study, the animals were anaesthetized with CO2 and humanely killed by exsanguination. Blood and other tissues were prepared for various clinical, histopathological and laboratory tests. Some beneficial effects of FOC, such as reduction in total serum cholesterol, in rats were confirmed. However, we also observed a significant reduction in absolute amount of serum HDL and a significant increase in relative liver and spleen weights in both sexes with the high dose of FOC. High doses of FOC (5 ml/kg/day) reduced serum iron and vitamin E concentrations. A reduction in osmotic fragility of RBC as well as an increase in RBC deformity were also observed in rats treated with high doses of FOC. These rats showed a significant overall increase in WBC count. It is concluded that in rats, subchronic consumption of high levels of FOC can be beneficial but may also be harmful because of induction of clinical abnormalities including increased red cell deformity, increased relative liver and spleen weights, and reduced serum HDL, iron and vitamin E concentrations.
KW - cholesterol
KW - erythrocytes
KW - fish oils
KW - food supplements
KW - high density lipoprotein
KW - iron
KW - laboratory animals
KW - leukocytes
KW - liver
KW - maize oil
KW - menhaden oil
KW - spleen
KW - toxicity
KW - vitamin E
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood red cells
KW - corn oil
KW - leucocytes
KW - red blood cells
KW - white blood cells
KW - Aquatic Produce (QQ060)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Behavioral responses of rats exposed to long-term dietary vinclozolin.
AU - Flynn, K. M.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Ferguson, S. A.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2001///
VL - 49
IS - 3
SP - 1658
EP - 1665
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Flynn, K. M.: Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013053452. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 50471-44-8. Subject Subsets: Soyabeans; Plant Pathology; Human Nutrition
N2 - Vinclozolin is a fungicide used on food crops with human exposure estimated at ~2 µg/kg/day from ingestion; occupational exposure, however, may be greater. The metabolites of vinclozolin have been reported to act as antiandrogens and have adverse effects on reproductive physiology and behaviour in animals. Here, pregnant rats were fed soy-free diets containing 0, 10, 150, or 750 ppm of vinclozolin (approximately 0, 0.8, 12, and 60 mg/kg/day for an adult) beginning on gestational day 7, and offspring were continued on these diets through sacrifice at postnatal day 77. Male and female offspring were assessed for changes in several nonreproductive sexually dimorphic behaviours: open field and running wheel locomotor activity, play behaviour, and consumption of saccharin- and sodium chloride-flavoured solutions. There was a significant interaction of sex with vinclozolin exposure on running wheel activity, which indicated that females in the high-dose exposure group were hypoactive compared to same-sex controls. There was a significant overall effect of vinclozolin exposure on fluid consumption, and high-dose animals showed increased intake of the saccharin solution and decreased intake of plain water while saccharin was available. Effects were more pronounced in females, which drank 40.8% more saccharin than control females, whereas males drank 6.2% more than control males. There were no effects of vinclozolin treatment on play behaviour or sodium solution intake. Gestational duration, total and live pups per litter, litter sex ratios, and birth weight were also not significantly affected, nor were body weight and food intake for dams and offspring. These results indicate that long-term dietary exposure to vinclozolin does not have severe toxicological consequences on the nonreproductive behaviours measured here. However, exposure may cause subtle alterations in locomotor activity and consumption of saccharin-flavoured solution.
KW - behaviour
KW - diets
KW - feeding behaviour
KW - female animals
KW - laboratory animals
KW - male animals
KW - physical activity
KW - pregnancy
KW - sex differences
KW - vinclozolin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - feeding behavior
KW - gestation
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational and take-home lead poisoning associated with restoring chemically stripped furniture - California, 1998.
AU - Materna, B.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2001///
VL - 50
IS - 13
SP - 246
EP - 248
CY - Atlanta; USA
PB - US Department of Health and Human Services, Centers for Disease Control and Prevention
SN - 0149-2195
AD - Materna, B.: Occupational Lead Poisoning Prevention Program, California Dept of Health Svcs. Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, California, USA.
N1 - Accession Number: 20013061664. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - Cases of lead poisoning in 6 furniture workers and their families were investigated in California, USA in 1998. The workers and their family members who might have been affected by lead toxicity underwent blood lead level (BLL) and zinc photoporphyrin tests. Results revealed that all 6 workers had elevated BLLs: the 2 refinishers had BLLs of 29 and 54 µg/dl, and the 4 carpenters had BLLs of 46, 46, 47 and 56 µg/dl. Five of the 6 family members, aged 7-12 years, did not have elevated BLLs; however, a 7-month-old infant, whose father's BBL was >40 µg/dl, had a BLL of 16 µg/dl. After lead safety measures were implemented, the workers' BLLs declined, and the average BLL decreased 15 µg/dl in approximately 3 months. It is concluded that lead toxicity is due to airborne lead dust released after processing of previously painted or coated stripped wood. A comprehensive lead safety procedure that includes exposure monitoring, good hygiene practices, medical examinations, protective clothing, respiratory protection, safe dust clean-up methods and training in furniture workshops is recommended.
KW - case reports
KW - dust
KW - furniture
KW - human diseases
KW - lead
KW - lead poisoning
KW - occupational hazards
KW - paintings on wood
KW - wood workers
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Industrial Wastes and Effluents (XX400)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure, resistance, and recovery: a three-dimensional framework for the study of mortality from infectious disease.
AU - Kirby, J. B.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2001///
VL - 53
IS - 9
SP - 1205
EP - 1215
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0277-9536
AD - Kirby, J. B.: Agency for Healthcare Research and Quality, 2101 East Jefferson Street, Rockville, MD 20852, USA.
N1 - Accession Number: 20013131517. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Rural Development; Tropical Diseases
N2 - It has been suggested by several scholars that debates surrounding the study of mortality could benefit from a framework that integrates social and economic factors with the biological mechanisms of illness and death. In this paper, I present a conceptual framework aimed at doing this for infectious disease mortality. The framework is built around three proximate processes: (1) exposure to potentially lethal pathogens, (2) resistance to disease pathogens after exposure, and (3) recovery from disease episodes after contraction. I apply this conceptual framework to morbidity and mortality from cholera across 41 less developed nations.
KW - disease resistance
KW - infectious diseases
KW - mortality
KW - recovery
KW - socioeconomics
KW - Developing Countries
KW - countries
KW - communicable diseases
KW - death rate
KW - resistance to disease
KW - socioeconomic aspects
KW - Third World
KW - Underdeveloped Countries
KW - Health Economics (EE118) (New March 2000)
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The importance of international activities to the work of the Food and Drug Administration's Center for Food Safety and Applied Nutrition.
AU - Levitt, J. A.
AU - Wehr, H. M.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 2001///
VL - 56
IS - 1
SP - 1
EP - 9
CY - Washington; USA
PB - Food and Drug Law Institute
SN - 1064-590X
AD - Levitt, J. A.: Food and Drug Administration's (FDA's) Center for Food Safety and Applied Nutrition (CFSAN), Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20013149931. Publication Type: Journal Article. Language: English. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - This article focuses on the emerging importance of the international sector and related trade issues to the priorities of the Center for Food Safety and Applied Nutrition (CFSAN) under the US Food and Drug Administration (FDA). The underlying principles, categories and activity areas of the CFSAN's Affirmative Agenda for International Activities are outlined. The activities undertaken by the CFSAN as part of the Food Safety Initiative programme are discussed. The role of FDA/CFSAN in the work of Codex is also described.
KW - Codex Alimentarius
KW - food
KW - food policy
KW - food safety
KW - foods
KW - international trade
KW - nutrition
KW - Agencies and Organizations (DD100)
KW - Food Economics (EE116) (New March 2000)
KW - International Trade (EE600)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Energy for a new millennium-regulatory perspectives.
AU - Yetley, E. A.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2001///
VL - 59
IS - 1(Part II)
SP - S33
EP - S34
CY - Lawrence; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Yetley, E. A.: Center for Food Safety and Applied Nutrition, Food & Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20013037239. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition
N2 - A review of the regulatory decisions about energy-related claims on foods is presented.
KW - energy
KW - labelling
KW - regulations
KW - reviews
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - labeling
KW - labels
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Diet Studies (VV110)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Polycystic kidney disease induced in F1 Sprague-Dawley rats fed para-Nonylphenol in a soy-free, casein-containing diet.
AU - Latendresse, J. R.
AU - Newbold, R. R.
AU - Weis, C. C.
AU - Delclos, K. B.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001///
VL - 62
IS - 1
SP - 140
EP - 147
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Latendresse, J. R.: Pathology Associates International, National Center for Toxicological Research, P.O. Box 26, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023154076. Publication Type: Journal Article. Language: English. Registry Number: 9000-71-9. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - para-Nonylphenol (NP; CAS #84852-15-3), an alkylphenol with a 9-carbon olefin side chain, is widely used in the manufacture of nonionic surfactants, lubricant additives, polymer stabilizers, and antioxidants. Due to its wide commercial use and putative endocrine activity in humans and wildlife, the NTP elected to assess its effects on reproduction in multigenerational studies. To avoid known estrogenic activity of phytoestrogens in soy and alfalfa, a soy- and alfalfa-free, casein-containing diet was used in a range-finding study to determine the doses of NP to be tested further. NP was administered to Sprague-Dawley rats in the diet at 0, 5, 25, 200, 500, 1000, or 2000 ppm to F0 dams beginning on gestation-day 7. The F1 pups were weaned at postnatal day (PND) 21, and their exposure via diet was continued at the same dose level as their respective dams. Pup weights from birth through weaning were not significantly different from controls in any dose group, but the average weight of both sexes was significantly less compared to controls, beginning with the PND 28 weighing. The F1 rats were sacrificed on PND 50 (n=15, 3 pups of each sex from 5 litters for all dose groups). Terminal body weights of males and females in the 2000-ppm dose group were 74% and 85% of controls, respectively. Severe polycystic kidney disease (PKD) was present in 100% of the 2000 ppm-exposed male and female rats. At 1000 ppm, 67% of males and 53% of females had mild to moderate PKD versus none of either sex in the control and lower-dose groups. The no-adverse-effect level (NOAEL) for PKD was determined to be 500 ppm. Previous studies with comparable duration and route of exposure, but using soy-containing diets, reported either no or only mild PKD at 2000 ppm NP. We conclude that the renal toxicity of NP is highly dependent on the diet on which the animals are maintained. The potential interaction of diet and test compounds on nonreproductive as well as reproductive endpoints should be considered when contemplating the use of special diets formulated to minimize exogenous "hormone" content for the study of the effects of putative endocrine disruptive chemicals.
KW - animal models
KW - body weight
KW - casein
KW - diets
KW - kidney diseases
KW - kidneys
KW - laboratory animals
KW - phenols
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - kidney disorders
KW - nephropathy
KW - nonylphenols
KW - polycystic kidney disease
KW - renal diseases
KW - Animal Models of Human Nutrition (VV140)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023154076&site=ehost-live&scope=site
UR - email: jlatendresse@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of Stachybotrys mycotoxins in building-related illness.
AU - Page, E. H.
AU - Trout, D. B.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 2001///
VL - 62
IS - 5
SP - 644
EP - 648
CY - Fairfax; USA
PB - American Industrial Hygiene Association
SN - 1529-8663
AD - Page, E. H.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-10, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20013155636. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Recently there has been increased attention among both the public and health professionals regarding the potential role of mycotoxins, primarily from fungi of the genus Stachybotrys, as aetiologic agents related to illness among persons exposed in the indoor (nonindustrial) environment. Recommendations for the remediation of buildings are being made based in part on reported health effects believed to be due to mycotoxins. A search of NIOSHTIC (a literature database maintained by the National Institute for Occupational Safety and Health) and MEDLINE (from 1965 to present) for literature related to fungi, mycotoxins, and the indoor environment was conducted. References from relevant articles also were reviewed. This strategy yielded a total of 13 articles. Important issues concerning exposure assessment and case definitions are inadequately addressed in the literature reviewed, making it difficult to implicate mycotoxins as a cause of building-related illness. The literature review indicates that currently there is inadequate evidence supporting a causal relationship between symptoms or illness among building occupants and exposure to mycotoxins. Research involving the identification and isolation of specific fungal toxins in the environment and in humans is needed before a more definitive link between health outcomes and mycotoxins can be made.
KW - buildings
KW - exposure
KW - human diseases
KW - mycoses
KW - mycotoxins
KW - public health
KW - respiratory diseases
KW - reviews
KW - man
KW - Stachybotrys
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - lung diseases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013155636&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data.
AU - Young, J. F.
AU - Wosilait, W. D.
AU - Luecke, R. H.
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2001///
VL - 63
IS - 1
SP - 19
EP - 52
CY - London; UK
PB - Taylor & Francis Ltd
SN - 1528-7394
AD - Young, J. F.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20013136273. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 593-74-8. Subject Subsets: Pig Science
N2 - Physiologically based pharmacokinetic (PBPK) models are excellent tools to aid in the extrapolation of animal data to humans. When the fate of the chemical is the same among species being compared, animal data can appropriately be considered as a model for human exposure. For methylmercury exposure, sufficient data exist to allow comparison of numerous mammalian species to humans. PBPK model validation entails obtaining blood and tissue concentrations of the parent chemical and metabolite(s) at various times following a known exposure. From ethical and practical considerations, human tissue concentrations following a known exposure to an environmental toxicant are scarce. While animal-to-human extrapolation demands that sufficient human data exist to validate the model, the validation requirements are less stringent if multiple animal models are utilized within a single model template. A versatile PBPK model was used to analyze the distribution and elimination of methylmercury and its metabolite, inorganic mercury. Uniquely, the model is formed in a generic way from a single basic template during the initial program compilation. Basic parameters are defined for different PBPK models for mammalian species that span a relatively large range of sizes. In this article, the analyses include 12 species (mouse, hamster, rat, guineapig, cat, rabbit, monkey, sheep, pig, goat, cow, and human). Allometric (weight-based) correlations of tissue binding coefficients, metabolism rate constants, and elimination parameters for both methylmercury and inorganic mercury are presented for species for which sufficient data are available. The resulting human model, in accord with the animal models, predicts relatively high inorganic mercury levels in the kidneys long after the disappearance of methylmercury from the blood.
KW - animal models
KW - cows
KW - disease models
KW - excretion
KW - exposure
KW - inorganic mercury fungicides
KW - laboratory animals
KW - metabolites
KW - methylmercury
KW - pesticide residues
KW - pharmacokinetics
KW - toxic substances
KW - toxicology
KW - cats
KW - cattle
KW - Cricetulus barabensis
KW - goats
KW - guineapigs
KW - man
KW - mice
KW - monkeys
KW - pigs
KW - rabbits
KW - rats
KW - sheep
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - Cricetulus
KW - Cricetinae
KW - Muridae
KW - rodents
KW - Capra
KW - Cavia
KW - Caviidae
KW - Homo
KW - Hominidae
KW - Primates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Leporidae
KW - Lagomorpha
KW - Ovis
KW - guinea pigs
KW - hogs
KW - poisons
KW - swine
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013136273&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods.
AU - El-Yazal, J.
AU - Rao, S. N.
AU - Mehl, A.
AU - Slikker, W., Jr.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001///
VL - 63
IS - 2
SP - 223
EP - 232
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - El-Yazal, J.: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023079550. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 51-84-3, 9000-81-1.
N2 - Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. In this light, molecular modelling studies were performed on a collection of organophosphorous acetylcholinesterase inhibitors by the combined use of conformational analysis and 3D-QSAR methods to rationalize their inhibitory potencies against the enzyme. The Catalyst programme was used to identify the structural features in the group of 8 inhibitors whose IC50 values ranged from 0.34 nM to 1.2 µM. The 3-D pharmacophore models are characterized by at least one hydrogen bond acceptor site and 2-3 hydrophobic sites and demonstrate very good correlation between the predicted and experimental IC50 values. Our models can be useful in screening databases of organophosphorous compounds for their neurotoxicity potential via the inhibition of acetylcholinesterase. Also, the pharmacophores offer an additional means of designing AChE inhibitors as potential therapeutic agents for central nervous system diseases.
KW - acetylcholine
KW - acetylcholinesterase
KW - hydrogen bonding
KW - neurotoxicity
KW - neurotransmitters
KW - organophosphorus compounds
KW - organic phosphorus compounds
KW - organophosphates
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023079550&site=ehost-live&scope=site
UR - email: wslikker@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surface plasmon resonance analysis of staphylococcal enterotoxin B in food.
AU - Rasooly, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 1
SP - 37
EP - 43
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Rasooly, A.: Division of Microbiological Studies, U.S. Food and Drug Administration, Washington, D.C. 20204, USA.
N1 - Accession Number: 20013037986. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Surface plasmon resonance (SPR) biosensors are electro-optical instruments used for analyzing real-time protein-protein interactions. This work evaluates an SPR biosensor (Biacore 3000) in the detection of staphylococcal enterotoxin B (SEB) in foods. A sandwich SPR immunosensor involving two antibodies was used. The capturing antibody, bound covalently to the surface of the biosensor chip, performs the initial binding of the antigen and a second antibody binds to the captured antigen. The second antibody makes antigen verification possible and amplifies the signal. Pure SEB as well as SEB in spiked foods (milk and meat) were detected with little interference from the food matrix. In the control experiments with uncontaminated food samples no significant signal was detected. The SPR biosensor assay detects SEB at ~10 ng/ml rapidly, with initial binding within 2 minutes. The entire measurement cycle (including washing and chip regeneration) may take 5 minutes using one antibody or 8 minutes using two antibodies. These results suggest that the SPR biosensor may be a useful tool for real-time analysis of toxin in foods.
KW - analytical methods
KW - biosensors
KW - enterotoxins
KW - meat
KW - microbial contamination
KW - milk
KW - resonance
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013037986&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hot water immersion to eliminate Escherichia coli O157:H7 on the surface of whole apples: thermal effects and efficacy.
AU - Fleischman, G. J.
AU - Bator, C.
AU - Merker, R.
AU - Keller, S. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 4
SP - 451
EP - 455
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Fleischman, G. J.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Avenue, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20013056493. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Horticultural Science; Postharvest Research
N2 - The effect of hot water immersion on both the reduction of Escherichia coli O157:H7 on the apple surface and internal temperatures of the apple was assessed in this study. Microbial reductions were measured experimentally, whereas internal temperatures were calculated through a mathematical analysis of experimental heat transfer data obtained from the apples. A method was developed to provide a purely surface-based inoculation of E. coli O157:H7. Rinsing produced no reduction, and treatments at 80 and 95°C produced reductions of more than 5 logs in 15 s or less. The heat transfer analysis based on experimental data was used to calculate surface heat transfer coefficients and predict temperatures throughout the apple. The analysis indicated a low heat transfer rate. Although it reduces thermal degradation, a low heat transfer rate precludes thermal-based reduction of any internalized microorganisms.
KW - apples
KW - efficacy
KW - food contamination
KW - hot water treatment
KW - Escherichia coli
KW - Malus
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013056493&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Production of alternariol and alternariol methyl ether by Alternaria alternata grown on fruits at various temperatures.
AU - Tournas, V. H.
AU - Stack, M. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 4
SP - 528
EP - 532
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Tournas, V. H.: Division of Natural Products, Food and Drug Administration, 200 C Street S.W., Washington, D.C. 20204, USA.
N1 - Accession Number: 20013056553. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 641-38-3. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - Two toxigenic strains of the fungus Alternaria alternata (ATCC 56836 and ATCC 66868) were grown on surface-disinfected, fresh, ripe fruits and tested for the production of alternariol (AOH) and alternariol methyl ether (AME). Examined fruits included strawberries; red and green seedless grapes; concord grapes; red delicious, golden delicious, and gala apple; and blueberries. After inoculation, fruits were incubated at 4, 10°C, or room temperature (approximately 21°C) for up to 3 weeks. At weekly intervals, duplicate samples were analysed for AOH and AME by using liquid chromatography. Results indicated that A. alternata and its metabolites were not a major problem in strawberries due to the presence of fast-growing moulds like Rhizopus and Botrytis that outgrew and possibly inhibited Alternaria. Both Alternaria strains showed limited growth on apples, although fast-growing moulds were not present after surface disinfection; AOH and AME were produced only by the ATCC 56836 strain on the golden delicious and gala varieties, (ranging from <0.1 to 5 µg/g and <0.1 to 14 µg/g for AOH and AME, respectively). Restricted growth of both strains without toxin production occurred in blueberries, whereas moderate growth and AOH (<0.1 to 3,336 µg/g) and AME (<0.1 to 1,716 µg/g) production took place in grapes.
KW - alternariol
KW - apples
KW - blueberries
KW - fruits
KW - grapes
KW - growth
KW - mycotoxins
KW - strawberries
KW - temperature
KW - varieties
KW - Alternaria alternata
KW - Fragaria
KW - Malus
KW - Vaccinium
KW - Vitidaceae
KW - Vitis
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Ericaceae
KW - Ericales
KW - Vitidaceae
KW - Rhamnales
KW - alternariol methyl ether
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - Vitaceae
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Growth of Salmonella during sprouting of alfalfa seeds associated with salmonellosis outbreaks.
AU - Stewart, D. S.
AU - Reineke, K. F.
AU - Ulaszek, J. M.
AU - Tortorello, M. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 5
SP - 618
EP - 622
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Stewart, D. S.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20013071488. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 7778-54-3. Subject Subsets: Seed Science; Human Nutrition; Postharvest Research
N2 - Growth of Salmonella was assessed during sprouting of naturally contaminated alfalfa seeds associated with 2 outbreaks of salmonellosis. Salmonella was determined daily in sprouts and sprout rinse water samples by a three-tube most probable number (MPN) procedure and a commercial enzyme immunoassay (EIA). Growth of Salmonella in the sprouts was reflected in the rinse water, and the MPNs of the 2 samples were generally in agreement within approximately 1 log. The results from EIA testing of sprouts and water samples were also in agreement. The pathogen was present in the seed at less than 1 MPN/g, and it increased in number to maximum population levels of 102 to 103 MPN/g in one seed lot and 102 to 104 MPN/g in the other seed lot. Maximum populations of the pathogen were apparent by day 2 of sprouting. These results show the ability of the pathogen to grow to detectable levels during the sprouting process, and they provide support for the recommendation to test the sprout water for the presence of pathogens 48 h after starting seed sprouting. The effectiveness of a 10-minutes, 20 0000-µg/ml (ppm) calcium hypochlorite treatment of the outbreak-associated seeds was studied. For both seed lots, the hypochlorite treatment caused a reduction, but not elimination, of Salmonella contamination in the finished sprouts. These results confirm the need to test each production batch for the presence of pathogens, even after 20 000 µg/ml (ppm) hypochlorite treatment of seeds, so that contaminated product is not distributed.
KW - calcium hypochlorite
KW - disinfection
KW - lucerne
KW - outbreaks
KW - salmonellosis
KW - seed contamination
KW - seeds
KW - sprouts
KW - Medicago
KW - Medicago sativa
KW - Salmonella
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Medicago
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - alfalfa
KW - bacterium
KW - Salmonella infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013071488&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An improved method for the recovery of Salmonella serovars from orange juice using Universal Preenrichment broth.
AU - Hammack, T. S.
AU - Amaguaña, R. M.
AU - Andrews, W. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 5
SP - 659
EP - 663
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Hammack, T. S.: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C Street S.W., HFS-516, Washington, D.C. 20204, USA.
N1 - Accession Number: 20013071277. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 62-42-3. Subject Subsets: Dairy Science; Sugar Industry; Human Nutrition
N2 - The relative effectiveness of 3 methods for the recovery of Salmonella serovars from orange juice was determined. One method, a modified Bacteriological Analytical Manual (BAM) procedure consisted of preenrichment in lactose broth at 35°C for 24 h, selective enrichment, and selective plating. Another method, a National Centers for Disease Control and Prevention (CDC 1) procedure, consisted of direct enrichment in tetrathionate broth at 35°C for 24 and 48 h, followed by selective plating. The third method (also from CDC and designated CDC 2) consisted of preenrichment in Universal Preenrichment (UP) broth at 35°C for 24 h, selective enrichment, and selective plating. In 10 experiments encompassing 5 different Salmonella serovars and 200 test portions per broth, the CDC 1 method recovered 141 Salmonella-positive test portions, the BAM method recovered 151, and the CDC 2 method recovered 171. In 2 of the 10 experiments, with 2 different Salmonella serovars, the BAM recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did the CDC 2 method. On the basis of the above results, the second phase of this study focused on a comparison of the effectiveness of the BAM-recommended lactose broth and the CDC 2-recommended UP broth as preenrichment media for the recovery of Salmonella serovars from pasteurized and unpasteurized orange juice. Subsequent culture treatment of the two preenrichments was identical so that the effect of other variables (e.g., different selective enrichment media, various incubation temperatures, and different selective plating agars) on the relative performance of these two preenrichment media was excluded. In 1 of 9 experiments, with pasteurized orange juice, lactose broth recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did UP broth. For the combined results of the 9 pasteurized orange juice experiments (180 test portions per broth), lactose broth recovered 99 Salmonella-positive test portions, and UP broth recovered 116. In 3 of 7 experiments, with unpasteurized orange juice, lactose broth recovered significantly fewer (P < 0.05) Salmonella-positive test portions than did UP broth. For the combined results of the 7 unpasteurized orange juice experiments (140 test portions per broth), lactose broth recovered 73 Salmonella-positive test portions, and UP broth recovered 117. For both pasteurized and unpasteurized orange juice, the total number of Salmonella-positive test portions recovered with UP broth was significantly greater than the number recovered with lactose broth. These results indicate that UP broth is a more effective enrichment broth for the recovery of Salmonella from orange juice than is lactose broth.
KW - food contamination
KW - lactose
KW - methodology
KW - orange juice
KW - serovars
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - methods
KW - milk sugar
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013071277&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Automated ribotyping differentiates Vibrio parahaemolyticus O3:K6 strains associated with a Texas outbreak from other clinical strains.
AU - Gendel, S. M.
AU - Ulaszek, J.
AU - Nishibuchi, M.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2001///
VL - 64
IS - 10
SP - 1617
EP - 1620
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Gendel, S. M.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20013144386. Publication Type: Journal Article. Language: English. Number of References: 14 ref.
N2 - Automated ribotyping with a Qualicon Riboprinter was used to determine whether clinical isolates of Vibrio parahaemolyticus O3:K6 recovered during two U.S. outbreaks of oyster-associated gastroenteritis in 1998 were related to each other and to a previously identified highly virulent Asian clone of this serotype. The patterns produced using the restriction enzymes Eco RI and Pst I suggest that the outbreak in the Northeastern United States was caused by a single strain closely related to the Asian clone. In contrast, it appears that multiple strains were involved in the Texas outbreak and that the predominant type was genetically distinct from the Northeastern and Asian clone.
KW - foodborne diseases
KW - gastroenteritis
KW - oysters
KW - Texas
KW - USA
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - bacterium
KW - ribotypes
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013144386&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in Western Kenya: Asembo Bay cohort project VIII.
AU - Udhayakumar, V.
AU - Kariuki, S.
AU - Kolczack, M.
AU - Girma, M.
AU - Roberts, J. M.
AU - Oloo, A. J.
AU - Nahlen, B. L.
AU - Lal, A. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2001///
VL - 65
IS - 2
SP - 100
EP - 107
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Udhayakumar, V.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20013124502. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - During June 1995-Septembr 1996, we investigated the development and maintenance of proliferative and antibody responses to apical membrane antigen-1 (AMA-1) epitopes in a holoendemic area of western Kenya. Young children (<10 years), older children (10-17 years), and adults (≥18 years) were followed longitudinally for antibody and T-cell responses at 3 time points with an interval of 3-4 months. The proliferative responses against the AMA-1 T epitopes (PL171, PL172, PL173, PL186, PL191, and PL192) were not stable during follow-up; however, response to mycobacterial antigen PPD was highly stable. The responder frequencies were similar in all 3 time points except for epitope PL192. The younger and older children responded more frequently to T-cell epitopes, but the differences were not significant. A positive proliferative response to PL191 was associated with a significantly lower risk of parasitemia at subsequent follow-up (relative risk, 0.5; P=0.03). The presence of antibody response to B epitopes PL169, PL170, PL173, PL187, and PL192 in one time point was associated with a subsequent response (P=0.0001-0.008) suggesting a stable response. Younger (P=0.046) and older children (P=0.017) more frequently responded to epitope PL169 than did adults, and adults responded more frequently to PL187 than did younger children (P=0.009). Responses to AMA-1 T-cell epitopes were short lived, and antibody responses were relatively stable.
KW - adults
KW - antibodies
KW - antigens
KW - children
KW - immune response
KW - malaria
KW - natural immunity
KW - Kenya
KW - man
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - antigenicity
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013124502&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of HIV infection on age and cause of death for persons with haemophilia A in the United States.
AU - Chorba, T. L.
AU - Holman, R. C.
AU - Clarke, M. J.
AU - Evatt, B. L.
JO - American Journal of Hematology
JF - American Journal of Hematology
Y1 - 2001///
VL - 66
IS - 4
SP - 229
EP - 240
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0361-8609
AD - Chorba, T. L.: Global AIDS Program, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20023045347. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Public Health
N2 - Because of changes in factor replacement therapy and in treatment of human immunodeficiency virus (HIV) infection, we examined the death record data for persons with haemophilia A in the USA to evaluate the effects of HIV infection on age and causes of death. Multiple cause-of-death data from 1968 through 1998 were examined to assess death rates for persons with haemophilia A. ICD-9 coded causes of death from 1979 through 1998 were examined to assess long-term trends. From 1979 through 1998, 4781 deaths among persons with haemophilia A were reported, of which 2254 (47%) had HIV-related disease listed as a cause of death. In the late 1980s, mortality among persons with haemophilia A increased markedly, and the age-adjusted death rate peaked at 1.5 per 1 000 000 population in 1992. Median age at death decreased from 55 years in 1979-82 to 40.5 years in 1987-90, and increased to 46 years in 1995-98. In the period 1995-98, the median age of haemophilia A decedents with HIV-related disease was 33 years, compared to 72 years for those without HIV-related disease; the most frequently listed causes of death for those without HIV-related disease were haemorrhagic and circulatory phenomena; the most frequently listed for those with HIV-related disease were diseases of liver and the respiratory system. From 1995 to 1998, haemophilia A-associated deaths decreased by 41%, with a 78% decrease among those who had HIV-related disease. Although HIV infection has adversely effected mortality for persons with haemophilia A, the marked recent decrease in the death rate among persons with haemophilia A appears to reflect advances in care for those with HIV-related disease, and is consistent with a decline in HIV mortality observed in the general population.
KW - acquired immune deficiency syndrome
KW - age
KW - causes of death
KW - circulatory disorders
KW - concurrent infections
KW - epidemiology
KW - haemophilia
KW - haemorrhage
KW - hereditary diseases
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - liver diseases
KW - mortality
KW - respiratory diseases
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - bleeding
KW - blood circulation disorders
KW - circulatory diseases
KW - death rate
KW - hemophilia
KW - hemorrhage
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - lung diseases
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023045347&site=ehost-live&scope=site
UR - email: tlc2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4.
AU - Mitchell, G. V.
AU - Cook, K. K.
AU - Jenkins, M. Y.
AU - Grundel, E.
JO - International Journal for Vitamin and Nutrition Research
JF - International Journal for Vitamin and Nutrition Research
Y1 - 2001///
VL - 71
IS - 1
SP - 30
EP - 35
CY - Bern; Switzerland
PB - Hogrefe & Huber Publishers
SN - 0300-9831
AD - Mitchell, G. V.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20013035162. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 84-80-0, 1406-18-4, 12001-79-5, 127-40-2. Subject Subsets: Human Nutrition
N2 - The modulation of tissue concentrations of vitamin K by a lutein supplement preserved with natural vitamin E was studied in Fischer 344 rats. Vitamin K is necessary for blood coagulation and may be essential for tissue and bone health. Weanling male rats were fed the AIN-93G diet (control) or modified AIN-93G diets containing 0.3, 0.6, 1.2, 2.4 and 4.8 g supplement/100 g diet for 8 weeks. The supplement contained 5% lutein, 0.22% zeaxanthin and 2.2% natural vitamin E as a preservative. Concentrations of trans-phylloquinone in the plasma (nmol/mmol triglycerides) and heart were significantly reduced (P≤0.05) in rats fed the supplement. The reductions in trans-phylloquinone in the heart ranged from ~20 to 60% of the control. Concentrations of phylloquinone in the liver were significantly lower in the rats fed the supplement at levels ≥1.2 g/100 g diet than in the control rats. Ratios of cis/trans phylloquinone in liver and heart increased and concentrations of menaquinone-4 in heart decreased as the dietary level of the lutein supplement increased. The results suggest that the lutein supplement affected the absorption, tissue uptake and/or turnover rate of vitamin K. The presence of other components in the supplement confounded the interpretation of the biological effects of lutein alone on vitamin K metabolism.
KW - animal models
KW - food supplements
KW - heart
KW - liver
KW - menaquinones
KW - nutrient uptake
KW - phylloquinone
KW - vitamin E
KW - vitamin K
KW - xanthophyll
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lutein
KW - phytonadione
KW - vitamin K1
KW - Animal Models of Human Nutrition (VV140)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of techniques for enrichment and isolation of Escherichia coli O157:H7 from artificially contaminated sprouts.
AU - Weagant, S. D.
AU - Bound, A. J.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2001///
VL - 71
IS - 1
SP - 87
EP - 92
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Weagant, S. D.: Pacific Regional Laboratory Northwest, U.S. Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20013171612. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Soyabeans; Postharvest Research; Human Nutrition; Public Health
N2 - Because sprouted seed products are kept wet during and after production, have high levels of nutrients, and a neutral pH, they are subject to the outgrowth of pathogens such as Escherichia coli O157:H7. For these same reasons, these products also contain high levels of heterotrophic organisms and in particular coliform bacteria. Recent outbreaks have focused attention on the need to improve methodology for isolating this pathogen from sprouts. When 40 E. coli O157:H7 strains were grown in pure culture in enterohaemorrhagic E. coli enrichment broth (EEB) as prescribed in the U.S. FDA-Bacteriological Analytical Manual (FDA-BAM) and in EEB modified by varying the cefixime concentration, outgrowth for all strains in EEB was inhibited at 0.05 mg/l but for only 2 of 40 strains when the cefixime level was adjusted to 0.0125 mg/l. These two enrichment formulae were compared to modified E. coli broth (mEC), modified Tryptic Soy Broth with 20 mg/l novobiocin (mTSB + N), modified Buffered Peptone Water (mBPW), and mBPW with added 10 mg/l acriflavin, 10 mg/l cefsulodin, and 8 mg/l vancomycin (mBPW + ACV) for isolation of E. coli O157:H7 from sprouts. These comparisons were performed using low-level (0.12 to 0.42 cfu/g) artificially contaminated alfalfa [lucerne] and mixed salad sprouts. After enrichment, two isolation methods were compared for recovery; direct plating to Tellurite-Cefixime Sorbitol MacConkey agar (TCSMAC) and immunomagnetic separation (IMS) (Dynabeads anti-E. coli O157, Dynal, Oslo, Norway) followed by plating to TCSMAC. In addition, an immunoprecipitin detection kit, VIP (BioControl, Bellevue, WA), was evaluated for detection after enrichment. We found that five of the six enrichments were equivalent for detection or recovery while one enrichment (mTSB+N without agitation) was less productive. Incubation for 24 h was more effective in recovering E. coli O157:H7 from sprouts than 6 h for all enrichment broths. Plating after IMS was more productive than direct plating at these low levels of contamination, yielding recovery in 70 of 90 trials compared to 37 of 90 trials without IMS for six enrichments. The sensitivity of VIP for detection of E. coli O157:H7 varied depending on the enrichment broth. Because of the rapid rate of growth of E. coli O157:H7 in mBPW, the high productivity of mBPW + ACV after 24-h enrichment and its compatibility with both IMS and detection with immunoprecipitin tests, mBPW + ACV at 42°C with agitation was found to be the most promising enrichment protocol for testing sprouts.
KW - detection
KW - enrichment
KW - growth rate
KW - isolation techniques
KW - lucerne
KW - magnetic separation
KW - pathogens
KW - recovery
KW - sprouts
KW - techniques
KW - Escherichia coli
KW - Medicago
KW - Medicago sativa
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Medicago
KW - alfalfa
KW - bacterium
KW - E. coli
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use.
AU - Koehler, K. M.
AU - Baumgartner, R. N.
AU - Garry, P. J.
AU - Allen, R. H.
AU - Stabler, S. P.
AU - Rimm, E. B.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2001///
VL - 73
IS - 3
SP - 628
EP - 637
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Koehler, K. M.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-728, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013075049. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 68-19-9, 59-30-3, 6027-13-0. Subject Subsets: Human Nutrition
N2 - The serum total homocysteine concentration (tHcy), an indicator of folate status and a possible risk factor for vascular disease, is elevated with impaired renal function and poor vitamin B-12 status, which are common in the elderly. Our objective was to determine the association between tHcy, folate intake, alcohol consumption, and other lifestyle factors in elderly persons. This cross-sectional study used linear regression to model changes in tHcy. Subjects were 278 men and women from New Mexico, USA aged 66-94 years studied in 1993. Total folate intake was negatively associated with tHcy in models adjusted for age, sex, serum creatine, and serum albumin. We found an interaction between food folate intake and supplement use. Food folate intake had an inverse dose-response relation with tHcy that was limited to nonusers of supplements. Predicted tHcy was 1.5 µmol/litre lower in users of supplements containing folate and vitamin B-12 than in nonusers and was independent of food folate intake. We found a positive dose-response relation of coffee and tea intake with tHcy, a positive association for alcohol intake of ≥60 drinks/months compared with low intake, and an interaction of alcohol use with folate intake and supplement use. Compared with alcohol users, nonusers had higher predicted tHcy and a lower inverse dose-response relation of food folate intake with tHcy. The inverse association between folate intake and tHcy was strongest among nonusers of supplements and among alcohol drinkers. Identifying modifiable factors related to tHcy, a possible risk factor for vascular disease, is especially important in elderly persons.
KW - alcohol intake
KW - coffee
KW - cyanocobalamin
KW - elderly
KW - folic acid
KW - food intake
KW - food supplements
KW - homocysteine
KW - tea
KW - vitamin B12
KW - New Mexico
KW - USA
KW - Camellia sinensis
KW - Coffea
KW - man
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - aged
KW - alcohol consumption
KW - cobalamin
KW - elderly people
KW - folacin
KW - folate
KW - older adults
KW - senior citizens
KW - United States of America
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - UV doses of American children and adolescents.
AU - Godar, D. E.
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
Y1 - 2001///
VL - 74
IS - 6
SP - 787
EP - 793
CY - Oxford; UK
PB - Pergamon Press
SN - 0031-8655
AD - Godar, D. E.: U.S. Food and Drug Administration, Center for Devices and Radiological Health (HFZ-114), 12709 Twinbrook Parkway, Rockville, MD 20852, USA.
N1 - Accession Number: 20023065269. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health
N2 - The ultraviolet (UV) doses of American young adults were never measured, but are needed for assessing UV-related health risks. These doses were calculated using a novel approach. The National Human Activity Pattern Survey recorded the daily minute-by-minute activities of about 2000 young adults (0-19 years) over the course of 2 years to assess their exposure to environmental pollutants. From that survey, only the outdoor daylight data of northern and southern girls and boys were extracted and stratified by season and age to find the time American children (0-5 and 6-12 years) and adolescents (13-19 years) spend outside. They spend about 10% of the day outdoors, but only get about 30% of the available terrestrial UV radiation (on a horizontal plane). American children have about the same percent personal ambients as adults (3.1%), 2.8% for girls and 3.4% for boys. Adolescents have the lowest personal ambients (2.6%), 2.1% for girls and 3.1% for boys. To get their UV doses, their percent ambients are multiplied by the total available terrestrial UV. Excluding vacation, the erythemally weighted UV doses for American children are 25 kJ/m2/year, 23 for girls and 28 for boys. Adolescents get the lowest UV exposure of any group, 21 kJ/m2/year, 18 for girls and 24 for boys. Young adult northern girls get 18 kJ/m2/year and boys get 21 kJ/m2/year, whereas southern girls get 24 kJ/m2/year and boys get 31 kJ/m2/year. The youngest children (0-5 years) get slightly higher summer doses. Thus, we can now assess the UV-related health risks for American children and adolescents.
KW - adolescents
KW - children
KW - daylight
KW - dosage
KW - exposure
KW - public health
KW - ultraviolet radiation
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - teenagers
KW - United States of America
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023065269&site=ehost-live&scope=site
UR - email: deg@cdrh.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental Oesophagostomum bifurcum in monkeys.
AU - Eberhard, M. L.
AU - Kovacs-Nace, E.
AU - Blotkamp, J.
AU - Verwij, J. J.
AU - Asigri, V. A. A.
AU - Polderman, A. M.
JO - Journal of Helminthology
JF - Journal of Helminthology
Y1 - 2001///
VL - 75
IS - 1
SP - 51
EP - 56
CY - Wallingford; UK
PB - CAB International
SN - 0022-149X
AD - Eberhard, M. L.: US Public Health Service, Division of Parasitic Diseases, Department of Health and Human Services, CDC, 4770 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20013045290. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Helminthology; Tropical Diseases
N2 - In February 1994, Oesophagostomum bifurcum larvae, cultured from human faecal samples collected one month before in northern Ghana, were used to establish experimental infections in monkeys. A patent infection was established in a rhesus monkey (Macaca mulatta) and this infection was used to generate larvae to inoculate additional monkeys. In all, 17 animals were inoculated. 13 of 15 animals developed antibodies to the infection between 19 and 62 days post inoculation (PI); 2 animals had a positive response before inoculation. Four of 10 animals developed patent infections between 88 and 134 days and passed eggs in the faeces. Egg shedding was consistent in only one animal, but at low levels of one or 2 eggs per 2 mg direct smear, and extended over a 400 day period. In the other 3 animals, egg shedding was sporadic and of only 2-4 weeks duration. In 7 animals necropsied between 19 and 22 days PI, one to 17 early fourth-stage larvae were recovered from nodules in the bowel wall; in 8 animals examined at 314 days, 6 immature adult worms (early fifth stage) were recovered from nodules in the bowel wall. The morphological features and growth of these recovered larvae are described. Three animals were inoculated with larvae that had been dried for one week at 28°C; 2 animals began shedding eggs at 128 and 134 days PI, respectively. The present results suggest that the parasite obtained from humans is poorly adapted to lower primate hosts, and supports the concept that Oesophagostomum bifurcum found in humans and monkeys in the same geographical region of northern Ghana and Togo are distinct and that the infections in humans are not likely to represent zoonotic infections acquired from monkeys.
KW - animal parasitic nematodes
KW - experimental infections
KW - growth
KW - human diseases
KW - immune response
KW - laboratory animals
KW - larvae
KW - morphology
KW - nematode infections
KW - ova
KW - Ghana
KW - Macaca mulatta
KW - man
KW - monkeys
KW - Oesophagostomum bifurcum
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Oesophagostomum
KW - Chabertiidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - animal-parasitic nematodes
KW - immunity reactions
KW - immunological reactions
KW - nematode parasites of animals
KW - nematodes
KW - nematodes of animals
KW - Secernentea
KW - Strongylida
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Anatomy and Morphology (Wild Animals) (YY100) (New March 2000)
KW - Reproduction, Development and Life Cycle (Wild Animals) (YY200) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays.
AU - Davis, B. S.
AU - Chang, G. J. J.
AU - Cropp, B.
AU - Roehrig, J. T.
AU - Martin, D. A.
AU - Mitchell, C. J.
AU - Bowen, R.
AU - Bunning, M. L.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2001///
VL - 75
IS - 9
SP - 4040
EP - 4047
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Davis, B. S.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013160959. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology
N2 - Introduction of West Nile (WN) virus into the United States in 1999 created major human and animal health concerns. Currently, no human or veterinary vaccine is available to prevent WN viral infection, and mosquito control is the only practical strategy to combat the spread of disease. Starting with a previously designed eukaryotic expression vector, we constructed a recombinant plasmid (pCBWN) that expressed the WN virus prM and E proteins. A single intramuscular injection of pCBWN DNA induced protective immunity, preventing WN virus infection in mice and horses. Recombinant plasmid-transformed COS-1 cells expressed and secreted high levels of WN virus prM and E proteins into the culture medium. The medium was treated with polyethylene glycol to concentrate proteins. The resultant, containing high-titred recombinant WN virus antigen, proved to be an excellent alternative to the more traditional suckling-mouse brain WN virus antigen used in the immunoglobulin M (IgM) antibody-capture and indirect IgG ELISA. This recombinant antigen has great potential to become the antigen of choice and will facilitate the standardization of reagents and implementation of WN virus surveillance in the United States and elsewhere.
KW - ELISA
KW - IgM
KW - immunity
KW - immunization
KW - recombinant antigens
KW - recombinant DNA
KW - vaccination
KW - vaccines
KW - USA
KW - Culicidae
KW - horses
KW - mice
KW - West Nile virus
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - Muridae
KW - rodents
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - enzyme linked immunosorbent assay
KW - immune sensitization
KW - mosquitoes
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013160959&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and characterization of porcine endogenous retrovirus in porcine plasma and porcine factor VIII.
AU - Takefman, D. M.
AU - Wong, S.
AU - Maudru, T.
AU - Peden, K.
AU - Wilson, C. A.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2001///
VL - 75
IS - 10
SP - 4551
EP - 4557
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Takefman, D. M.: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room NN11, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20013164452. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9068-38-6. Subject Subsets: Veterinary Science; Pig Science; Veterinary Science
N2 - The pig genome contains porcine endogenous retroviruses (PERVs) capable of infecting human cells. Detection of infectious retrovirus in porcine peripheral blood mononuclear cells and endothelial cells suggested to us that pig plasma is likely to contain PERV. Both PERV env sequences and viral reverse transcriptase (RT) activity were detected in all plasma samples isolated from four NIH minipigs. To detect infectious virus from plasma, we performed a culture assay using three cell lines of feline, swine and human origin that had previously been shown to be permissive for PERV. Infectious virus was successfully cultured from all four NIH minipig plasmas on the swine cell line ST-IOWA. Using RT-PCR with env-specific primers, we could detect expression of PERV class C envelope in the supernatant of ST-IOWA cells that had been exposed to each pig plasma. We next examined a pig plasma derivative, Hyate:C (porcine factor VIII), and found evidence of PERV particles, since all six lots examined were positive for PERV RNA and RT activity. However, infectious virus could not be detected in clinical lots of Hyate:C, suggesting that the manufacturing process might reduce the load of infectious virus to levels below detectable limits of the assay. Detection of infectious virus in porcine plasma confirms and extends the previous findings that certain porcine cells express PERV when manipulated in vitro and clearly demonstrates that there are porcine cells that express infectious PERV constitutively in vivo.
KW - assays
KW - blood plasma
KW - cell lines
KW - derivatives
KW - disease models
KW - enzyme activity
KW - nucleotide sequences
KW - reverse transcriptase
KW - pigs
KW - Retroviridae
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Retroviridae
KW - DNA sequences
KW - hogs
KW - plasma (blood)
KW - porcine endogenous retroviruses
KW - swine
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013164452&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells.
AU - Crill, W. D.
AU - Roehrig, J. T.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2001///
VL - 75
IS - 16
SP - 7769
EP - 7773
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Crill, W. D.: Arbovirus Disease Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20013161592. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - The specific mechanisms by which antibodies neutralize flavivirus infectivity are not completely understood. To study these mechanisms in more detail, we analysed the ability of a well-defined set of anti-dengue (DEN) virus E-glycoprotein-specific monoclonal antibodies (MAbs) to block virus adsorption to Vero cells. In contrast to previous studies, the binding sites of these MAbs were localized to one of three structural domains (I, II, and III) in the E glycoprotein. The results indicate that most MAbs that neutralize virus infectivity do so, at least in part, by the blocking of virus adsorption. However, MAbs specific for domain III were the strongest blockers of virus adsorption. These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif.
KW - adsorption
KW - binding sites
KW - glycoproteins
KW - infectivity
KW - monoclonal antibodies
KW - dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - binding site
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013161592&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of standard addition to eliminate conjugated linoleic acid and other interferences in the determination of total trans fatty acids in selected food products by infrared spectroscopy.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Fritsche, J.
AU - Yurawecz, M. P.
AU - Eulitz, K. D.
AU - Ku, Y.
AU - Rader, J. I.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 2001///
VL - 78
IS - 6
SP - 631
EP - 634
CY - Champaign; USA
PB - AOCS Press
SN - 0003-021X
AD - Mossoba, M. M.: U.S. Food and Drug Administration (mail stop HFS-717), Center for Food Safety and Applied Nutrition, 200 C Street, S.W., Washington, DC 20204, USA.
N1 - Accession Number: 20013108414. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 60-33-3. Subject Subsets: Dairy Science; Human Nutrition
N2 - A novel and rapid (5 min) attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic method AOCS Cd 14d-99 for the determination of total isolated trans fatty acids, which absorb at 966 cm-1, was recently developed, collaboratively studied, and applied to food products containing 1-50% trans fat (as percentage of total fat). Attempts to apply the ATR-FTIR method to biological matrices of low trans fat and/or low total fat content, and to dairy and other products were not satisfactory due to interfering IR absorptions in the trans region. One group of interfering compounds with absorption bands near 985 and 948 cm-1 was the cis/trans positional isomers of conjugated linoleic acid (CLA) found in dairy and meat products from ruminants at levels of <1% (as percentage of total fat). In the present study, we modified the ATR-FTIR method to overcome matrix interferences. This modification, which consisted of applying the standard addition technique to the ATR-FTIR determination, was also applied to several food products, namely, dairy products, infant formula and salad oil dressing, which successfully eliminated interfering absorbances that impacted on accuracy. The presence of <1% CLA in two butter and two cheese products containing 6.8, 7.5, 8.5, and 10.4% trans fatty acids (as a percentage of total fat) would have led to errors of -11.6, 10.4, 17.6 and 34.6%, respectively, in trans fat measurements had the standard addition technique not been used. The applicability of ATR-FTIR to the quantitation of food products is discussed.
KW - butter
KW - cheeses
KW - fatty acids
KW - food composition
KW - infant formulae
KW - infrared spectroscopy
KW - linoleic acid
KW - meat products
KW - milk products
KW - quantitative techniques
KW - salad dressings
KW - dairy products
KW - infant formula
KW - infant formulas
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013108414&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malaria control in Bungoma District, Kenya: a survey of home treatment of children with fever, bednet use and attendance at antenatal clinics.
AU - Hamel, M. J.
AU - Odhacha, A.
AU - Roberts, J. M.
AU - Deming, M. S.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2001///
VL - 79
IS - 11
SP - 1014
EP - 1023
CY - Geneva; Switzerland
PB - World Health Organization
SN - 0042-9686
AD - Hamel, M. J.: International Child Survival and Emerging Infections Program Support Office, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, 4770 Buford Highway, Mailstop F-22, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20013170286. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 26 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2 - Objective: To lay the basis for planning an improved malaria control programme in Bungoma District, Kenya. Methods: By means of a cluster sample household survey in July 1996, an investigation was conducted into the home management of febrile children, the use of bednets, and attendance at antenatal clinics. Findings: Female carers provided information on 314 recently febrile children under 5 years of age, of whom 43% received care at a health facility, 47% received an antimalarial drug at home, and 25% received neither. Of the antimalarial treatments given at home, 91% were started by the second day of fever and 92% were with chloroquine, the nationally recommended antimalarial at the time. The recommended dosage of chloroquine to be administered over three days was 25 mg/kg but the median chloroquine tablet or syrup dosage given over the first three days of treatment was 15 mg/kg. The total dosages ranged from 2.5 mg/kg to 82 mg/kg, administered over one to five days. The dosages were lower when syrup was administered than when tablets were used. Only 5% of children under 5 years of age slept under a bednet. No bednets had been treated with insecticide since purchase. At least two antenatal visits were made by 91% of pregnant women. Conclusions: Carers are major and prompt providers of antimalarial treatment. Home treatment practices should be strengthened and endorsed when prompt treatment at a health facility is impossible. The administration of incorrect dosages, which proved common with chloroquine, may occur less frequently with sulfadoxine-pyrimethamine, as its dosage regimen is simpler. High levels of utilization of antenatal clinics afford the opportunity to achieve good coverage with presumptive intermittent malaria treatments during pregnancy, and to reach the goal of widespread bednet use by pregnant women and children by distributing nets during antenatal clinic visits.
KW - antimalarials
KW - bed nets
KW - children
KW - chloroquine
KW - disease control
KW - drug therapy
KW - fever
KW - health clinics
KW - human diseases
KW - malaria
KW - pregnancy
KW - women
KW - Kenya
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - chemotherapy
KW - gestation
KW - pyrexia
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Other Control Measures (HH700)
KW - Human Reproduction and Development (VV060)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rappaport-Vassiliadis medium for recovery of Salmonella spp. from low microbial load foods: collaborative study.
AU - Hammack, T. S.
AU - Amaguaña, R. M.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 1
SP - 65
EP - 83
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-516, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013027882. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Twenty-three laboratories participated in a collaborative study to compare the relative effectiveness of Rappaport-Vassiliadis (RV) medium incubated at 42°C, selenite cystine (SC) broth (35°), and tetrathionate (TT) broth (35 and 43°) for recovery of Salmonella from the following foods with a low microbial load: dried egg yolk, dry active yeast, ground black pepper, guar gum, and instant nonfat dry milk. For dry active yeast, lauryl tryptose (LT) broth, incubated at 35°, was used instead of SC broth. All of the foods were artificially inoculated with single Salmonella serovars, that had been lyophilized before inoculation, at high and low target levels of 0.4 and 0.04 colony forming units/g food, respectively. For analysis of 870 test portions, representing all of the foods except yeast, 249 Salmonella-positive test portions were detected by RV medium, 265 by TT broth (43°), 268 by TT broth (35°), and 269 by SC broth (35°). For analysis of 225 test portions of yeast, 79 Salmonella-positive test portions were detected by RV medium, 79 by TT broth (43°), 84 by TT broth (35°), and 68 by LT broth (35°). RV medium was comparable to, or even more effective than, the other selective enrichments for recovery of Salmonella from all of the foods except guar gum. It is recommended that RV (42°) and TT (35°) be used with foods that have a low microbial load, except for guar gum for which SC (35°) and TT (35°) are recommended.
KW - analytical methods
KW - culture media
KW - detection
KW - dried milk
KW - egg yolk
KW - foods
KW - microorganisms
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - micro-organisms
KW - milk powder
KW - yolk
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013027882&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 1
SP - 202
EP - 211
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, 200 C St. SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013027827. Publication Type: Journal Article. Language: English. Number of References: 116 ref. Subject Subsets: Animal Nutrition; Medical & Veterinary Mycology
KW - feeds
KW - foods
KW - guidelines
KW - mycotoxins
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - fungal toxins
KW - recommendations
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Crop Produce (QQ050)
KW - Toxinology (VV820) (New March 2000)
KW - Storage Problems and Pests of Food (QQ111)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Radioactivity.
AU - Baratta, E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 1
SP - 236
EP - 237
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Baratta, E.: U.S. Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St., Winchester, MA 01890, USA.
N1 - Accession Number: 20013027904. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Dairy Science
KW - food contamination
KW - foods
KW - milk
KW - radionuclides
KW - residues
KW - food contaminants
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Milk and Dairy Produce (QQ010)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiclass multiresidue methods for organic compounds.
AU - Parfitt, C. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 1
SP - 239
EP - 240
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Parfitt, C. H.: U.S. Food and Drug Administration, Division of Field Science (HFC-141), 5600 Fishers Ln, Rockville, MD 20857, USA.
N1 - Accession Number: 20013027905. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Dairy Science
KW - analytical methods
KW - food contamination
KW - foods
KW - milk
KW - pesticide residues
KW - pesticides
KW - residues
KW - analytical techniques
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Milk and Dairy Produce (QQ010)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food microbiology - non-dairy.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 1
SP - 243
EP - 250
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Andrews, W. H.: U.S. Food and Drug Administration, Division of Microbiological Studies, HFS-516, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013027907. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
KW - analytical methods
KW - food contamination
KW - foods
KW - microbial contamination
KW - microbiology
KW - microorganisms
KW - analytical techniques
KW - food contaminants
KW - micro-organisms
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013027907&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid methods to enumerate Escherichia coli in foods using 4-methylumbelliferyl-β-D-glucuronide.
AU - Ekholm, D. F.
AU - Hirshfield, I. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 2
SP - 407
EP - 415
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Ekholm, D. F.: U.S. Food and Drug Administration, Northeast Regional Laboratory, 158-15 Liberty Ave, Jamaica, NY 11433, USA.
N1 - Accession Number: 20013059389. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition; Postharvest Research; Dairy Science
N2 - Three methods to enumerate Escherichia coli in food were compared. They were based on AOAC methods using lauryl tryptose broth (LST) medium, LST-4-methylumbelliferyl-β-D-glucuronide (MUG) medium, and a proposed method using regular LST in combination with E. coli (EC)-MUG medium. An efficacious and cost-effective method is needed that can detect E. coli and does not produce false presumptive positives. We tested 170 cheeses, 40 frozen processed seafood samples, 210 tree nuts, and 40 other samples. The method of choice for enumerating E. coli depends on the commodity itself. For a product, such as hard cheese or processed seafood, with a history of being negative for E. coli and other lactose-fermenting organisms, the proposed method using regular LST/EC-MUG is a good choice. These samples were seldom presumptive positive in the primary LST medium. If gas was produced, EC-MUG was an effective secondary medium. No false positives (fluorescence) or negatives were detected in EC-MUG medium. For a product with a history of being positive for E. coli and/or other lactose fermenting organisms, such as tree nutmeats or cheeses that are ripened by bacteria or mould, the method using LST-MUG is the method of choice. A presumptive positive in the LST-MUG medium was highly correlative with the biochemical tests that confirmed a sample contain E. coli. For samples spiked with E. coli, the results from each of these 3 methods were identical, and were consistent in enumerating E. coli.
KW - cheeses
KW - culture media
KW - food contamination
KW - frozen foods
KW - methodology
KW - nuts
KW - seafoods
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - food contaminants
KW - methods
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013059389&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of methyl anthranilate in artificially flavored nonalcoholic beverages.
AU - Thompson, R. D.
AU - Quaife, J. T.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 2
SP - 493
EP - 497
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Thompson, R. D.: U.S. Food and Drug Administration, 240 Hennepin Ave, Minneapolis, MN 55401, USA.
N1 - Accession Number: 20013059450. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic method was developed that provides a simple and rapid means of determining methyl anthranilate (MA) in carbonated and noncarbonated, artificial grape-flavoured, nonalcoholic beverages. The proposed procedure, which was applied to 12 different products, uses a Nova-Pak C18 column, a mobile phase containing acetonitrile-0.025M KH2PO4 (40 + 60), pH 3.00, and UV detection at 220 nm. Assay values ranged from 0.35 to 16.6 µG MA/ml. The intralaboratory precision (relative standard deviation) for the products ranged from 0.51 to 2.23% (n = 5), and recoveries via fortification ranged from 83.6 to 102.4%. The limits of quantitation and detection were 0.00417 and 0.00125 µg/ml, respectively, and the analyte response was linear over a 100-fold concentration range (0.0001-0.01 mg/ml).
KW - artificial flavours
KW - benzoates (esters)
KW - beverages
KW - liquid chromatography
KW - methodology
KW - artificial flavor
KW - artificial flavors
KW - drinks
KW - methods
KW - Food Additives (QQ130)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013059450&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of iodine-131 at low levels in milk: collaborative study.
AU - Baratta, E. J.
AU - Easterly, D. G.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 2
SP - 507
EP - 511
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Baratta, E. J.: US Food and Drug Administration, 109 Holton Street, Winchester, MA 01890-1152, USA.
N1 - Accession Number: 20013059453. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7553-56-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - The official method for the determination of iodine-131 in milk has a lower limit of detection (LLD) of 10 pCi/litre (0.37 Bq/litre). The Nuclear Regulatory Commission had recommended that a method claiming to have an LLD of <0.3 pCi/litre (<1.1E-02 Bq/litre) be used. That method, which is capable of measuring iodine-131 below the level of detection of the Official Method, was collaboratively studied. The method uses a palladium iodide precipitate to concentrate the iodine-131 and measures (counts) its 364 keV gamma energy in coincidence with the beta decay or with a low-background beta-counting system. The study was performed by using 3 concentrations of iodine-131 in milk: 2.6, 5.0, and 8.0 pCi/litre (9.62E-02, 1.85E-01, and 2.96E-01 Bq/litre, respectively). 11 laboratories agreed to participate in the study. Eight laboratories submitted data for the study. The averages of the results were 2.68, 5.30, and 8.12 pCi/litre (9.92E-02, 1.96E-01, and 3.00E-01 Bq/litre, respectively), respectively. The intra- and interlaboratory variations were acceptable. The method was adopted First Action by AOAC INTERNATIONAL.
KW - analytical methods
KW - detection
KW - iodine
KW - milk
KW - radioactive wastes
KW - analytical techniques
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013059453&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extension of AOAC Official Method 996.01 to the analysis of Standard Reference Material (SRM) 1846 and infant formulas.
AU - Satchithanandam, S.
AU - Fritsche, J.
AU - Rader, J. I.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 3
SP - 805
EP - 814
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Satchithanandam, S.: U.S. Food and Drug Administration, Office of Nutritional Products, Labeling and Dietary Supplements, HFS-840, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013110758. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 60-33-3. Subject Subsets: Soyabeans; Dairy Science; Human Nutrition
N2 - There is currently no official method for the analysis of fatty acids (including trans fatty acids) in infant formulas. AOAC Official Method 996.01 for Fat Analysis in Cereal Products was extended to the analysis of milk-based infant formula Standard Reference Material (SRM) 1846 to determine its applicability for use with infant formulas. Following the analysis of SRM 1846, two infant formulas, one milk-based liquid and one soy-based powdered infant formula, were analysed for total fatty acid composition. Fatty acid methyl esters were prepared and analysed by gas chromatography. The results of the analysis of SRM 1846 show that the mean analysed values were highly reproducible as indicated by low coefficients of variation (CV). The CVs were <5% for the major fatty acids. Mean analysed values for individual fatty acids in SRM 1846 were within ± 1 standard deviation of the certificate values. The analysed value for total fat as triglycerides (26.27 ± 0.25%) agreed well with the certificate value (27.1 ± 0.59%). Analyses of infant formulas showed that the concentrations of linoleic acid and fat meet the requirements for such formulas.
KW - analytical methods
KW - fatty acids
KW - infant formulae
KW - linoleic acid
KW - triacylglycerols
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - triglycerides
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013110758&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Examination of proficiency and control recovery data from analyses for pesticide residues in food: sources of variability.
AU - Horwitz, W.
AU - Jackson, T.
AU - Chirtel, S. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 3
SP - 919
EP - 935
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Horwitz, W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-500, Washington, DC 20204, USA.
N1 - Accession Number: 20013117470. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Agricultural Entomology; Postharvest Research
N2 - We examined a number of large proficiency and control databases supporting the values reported for pesticide residues in agricultural commodities at fractions of a part per million (mg/kg). The average recovery from >100 000 recovery records in 13 databases was 94%. The overall average single-value relative standard deviation (RSD) of the reported recoveries was 17% at a mean concentration (C) of about 10-7 (0.1 mg/kg). The average apparent HORRAT value (RSD found/RSDR predicted from the Horwitz formula [2C-0.1505]) was 0.8. Analysis of variance indicated that approximately 60-70% of the variance could not be associated with any particular factor or combination of factors-analyte, commodity, method, laboratory, concentration, database, or their interactions. The most predominant factor, analyte, and its third-order interaction with laboratory and concentration contributed most of the assignable variance. These findings suggested that most of the variability of trace analysis for pesticide residues is random in the sense of being inherent and not assignable to specific factor fluctuations.
KW - databases
KW - pesticide residues
KW - pesticides
KW - plant products
KW - crop products
KW - data banks
KW - Information and Documentation (CC300)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013117470&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of nystatin in pharmaceutical preparations.
AU - Wilson, P.
AU - Stewart, A.
AU - Flournoy, V.
AU - Zito, S. W.
AU - Vancura, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 4
SP - 1050
EP - 1055
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Wilson, P.: U.S. Food and Drug Administration, NRL, 158-15 Liberty Ave, Jamaica, NY 11433, USA.
N1 - Accession Number: 20013122692. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 1400-61-9. Subject Subsets: Medical & Veterinary Mycology
N2 - A rapid, reversed-phase liquid chromatographic method was developed for the assay of nystatin in the bulk drug and a variety of dosage forms. Analysis was performed on a Symmetry C18 reversed-phase column using a mobile phase of methanol-water-dimethylformamide (DMF; 55+30+15, v/v/v), with detection by UV at 305 nm. Quantitation is based on the sum of the peak areas of the 2 major isomers of nystatin. The linearity of the assay was determined for a concentration range of 0.05 to 0.2 mg/mL (correlation coefficient >0.999). Accuracies and precision showed good reproducibility.
KW - accuracy
KW - analytical methods
KW - drugs
KW - nystatin
KW - pharmaceutical products
KW - reverse phase liquid chromatography
KW - analytical techniques
KW - ceratocide
KW - medicines
KW - pharmaceuticals
KW - Pharmacology (VV730) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013122692&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid determination of total trans fat content - an attenuated total reflection infrared spectroscopy international collaborative study.
AU - Mossoba, M. M.
AU - Adam, M.
AU - Lee, T.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 4
SP - 1144
EP - 1150
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mossoba, M. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, HFS-717, 200 C St, SW, Washington, DC 20204, USA.
N1 - Accession Number: 20013122708. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - Interest in trans fat labelling has prompted efforts to develop new, more efficient methods for rapidly and accurately determining trans fat content of foods. A novel and rapid (5 min) attenuated total reflection - Fourier transform infrared (ATR-FTIR) spectroscopic procedure was recently developed and applied to food products. This procedure was voted official method AOCS Cd 14d-99 by the American Oil Chemists' Society in 1999 after testing in a 12 laboratory international collaborative study. The results of the study are described in this paper. Analytical ATR-FTIR results exhibited high accuracy in the range 5-40% trans; results tended to have <2% high bias relative to the gravimetrically determined values. The precision of this internal reflection method was found to be superior to the precision of transmission infrared official methods. It is recommended that the applicability of the ATR-FTIR method be limited to trans levels of <5% (as percent of total fat).
KW - accuracy
KW - analytical methods
KW - fats
KW - food products
KW - infrared spectroscopy
KW - trans fatty acids
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - United States of America
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013122708&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of preformed type A botulinal toxin in hash brown potatoes by using the mouse bioassay and a modified ELISA test.
AU - Ferreira, J. L.
AU - Eliasberg, S. J.
AU - Harrison, M. A.
AU - Edmonds, P.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 5
SP - 1460
EP - 1464
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Ferreira, J. L.: U.S. Food and Drug Administration, 60 8th St, Atlanta, GA 30309, USA.
N1 - Accession Number: 20013149561. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Potatoes; Horticultural Science
N2 - A foodborne illness caused by type A toxin-producing Clostridium botulinum was investigated by using the standard mouse bioassay and a rapid in vitro test for toxin detection. The patient, who consumed improperly stored hash brown potatoes that contained the preformed toxin, was diagnosed with type A botulism. C. botulinum type A toxin was detected in the hash brown potatoes as well as in the tryptone-peptone-glucose-yeast extract (TPGY) medium subcultures of this food using the mouse bioassay and an amplified ELISA technique. The mouse bioassay revealed preformed toxin at 10 000 minimum lethal dose (MLD)/g uncooked product and the amplified ELISA an equivalent 50 000 MLD/g. The culture toxin from the uncooked product killed mice at the 106 dilution and a modification of the ELISA procedure was positive at the 103 dilution. Cooked food obtained from the consumer's waste can contained 100 MLD/g and the ELISA was also positive at the same dilution of the product. The culture of the cooked product obtained from the waste can was lethal for mice at the 107 dilution and positive using the modified ELISA at the 104 dilution. The unmodified amplified ELISA method indicated a toxin level of approximately 1 ng/ml (equivalent to 5 × 105 MLD/ml) in diluted culture fluid from the uncooked food and the culture of cooked food obtained from the waste can. The hash brown potatoes were negative for types B, E and F preformed and culture botulinal toxins using both assays.
KW - bacterial toxins
KW - bioassays
KW - ELISA
KW - food contamination
KW - lethal dose
KW - potato products
KW - potatoes
KW - Clostridium botulinum
KW - mice
KW - Solanum tuberosum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013149561&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of vitamin B6 in soy-based infant formula.
AU - Mann, D. L.
AU - Chase, G. W., Jr.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 5
SP - 1593
EP - 1599
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mann, D. L.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20013149219. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 65-23-6. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - A liquid chromatographic (LC) method is described for the determination of total vitamin B6 (pyridoxine) in soya-based infant formula. Total vitamin B6 was quantified using ion-pair LC after precolumn transformation of phosphorylated and free vitamers into pyridoxol. The limit of detection was 0.3 ng and the limit of quantitation was 1.0 ng on-column (injection volume=100 µl). Linear response ranged from 39-616 ng/ml (r2=0.99986). Analysis of a soya-based infant formula control fortified at 6 different concentration levels gave recoveries that averaged 104%. Assay of SRM 1846 gave results within the certified range (8.6±0.086 mg/kg versus the certified value of 8.4±1.0 mg/kg). The method provides a rapid and specific assay for the analysis of total vitamin B6 in fortified soya-based infant formula.
KW - analytical methods
KW - infant formulae
KW - liquid chromatography
KW - nutritive value
KW - pyridoxine
KW - soya milk
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - nutritional value
KW - quality for nutrition
KW - soy milk
KW - soyabean milk
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013149219&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of Cry9C protein in corn-based foods by enzyme-linked immunosorbent assay: interlaboratory study.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2001///
VL - 84
IS - 6
SP - 1891
EP - 1901
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20013175798. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 977050-51-3. Subject Subsets: Agricultural Biotechnology; Human Nutrition; Plant Breeding; Maize
N2 - The performance of a commercially available enzyme-linked immunosorbent assay (ELISA) kit (EnviroLogix) was assessed for the determination of Cry9C protein (from Bacillus thuringiensis), which is produced by the genetically modified corn StarLink in 8 types of corn-based foods (starch, refined oil, soft tortillas, tortilla chips, corn flakes, corn puffs, corn muffins and corn bread) in an interlaboratory study involving 7 laboratories in the United States. The assay kit is a double antibody sandwich and is based on the specific interaction between antibody and antigen. The Cry9C protein analyte is sandwiched between 2 antibodies, one to capture the analyte and the other is conjugated to the enzyme, horseradish peroxidase. The enzyme uses tetramethylbenzidine/peroxide for colour development. A strong acid stopping reagent is then used to change the colour from blue to a stable yellow. The intensity of the colour is proportional to the concentration of the Cry9C protein. In this study blind duplicates of control samples (blank material prepared from non- StarLink corn), spiked samples (blank material with the addition of Cry9C protein) and samples containing incurred analyte (products prepared with StarLink corn) were analysed. Cry9C protein from 2 different sources was used to spike the food products. Cry9C protein produced and purified from a bacterial host was used to prepare spiked test samples at 2.72 and 6.8 ng/g. Cry9C protein from StarLink corn flour was used to prepare spiked samples at 1.97 ng/g. Average recoveries for samples spiked with corn flour Cry9C protein at 1.97 ng/g ranged from 73 to 122%, within-laboratory relative standard deviations (RSDr) ranged from 6 to 22% and between-laboratories relative standard deviations (RSDR) ranged from 16 to 56%. Average recoveries for samples spiked with bacterial Cry9C protein at 2.72 and 6.8 ng/g ranged from 27 to 96% and from 32 to 113%, respectively; RSDr values ranged from 10 to 35% and from 7 to 38%, respectively; and the RSDR ranged from 28 to 84% and 15 to 75%, respectively. The incurred test samples were found to contain Cry9C protein at levels ranging from 0.8 to 3187 ng/g depending on the product, RSDr values ranged from 5 to 16% and RSDR values ranged from 11 to 71%. Results of the statistical analysis indicate that this method is applicable to the determination of Cry9C protein in the 8 types of collaboratively studied corn-based products containing Cry9C protein (from StarLink) at levels of ≥2 ng/g.
KW - analytical methods
KW - bacterial protein
KW - bread
KW - ELISA
KW - food products
KW - food quality
KW - foods
KW - genetically engineered organisms
KW - maize
KW - maize oil
KW - maize starch
KW - tortillas
KW - transgenic plants
KW - Bacillus thuringiensis
KW - plants
KW - Zea mays
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - analytical techniques
KW - bacterium
KW - corn
KW - corn oil
KW - corn starch
KW - enzyme linked immunosorbent assay
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - Field Crops (FF005) (New March 2000)
KW - Plant Breeding and Genetics (FF020)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013175798&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emergence and transfer of antibacterial resistance.
AU - White, D. G.
AU - McDermott, P. F.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2001///
VL - 84
SP - E151
EP - E155
CY - Savoy; USA
PB - American Dairy Science Association
SN - 0022-0302
AD - White, D. G.: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20013160774. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Veterinary Science; Veterinary Science
N2 - There is increased public and scientific interest regarding the administration of therapeutic and subtherapeutic antimicrobials to animals. This is due primarily to the emergence and dissemination of multiple antibiotic resistant zoonotic bacterial pathogens. The debate regarding antimicrobial use in animals and subsequent human health implications has been going on for over 30 years. This was initiated by the release of the Swann report in the United Kingdom in 1969. While this issue has triggered a tremendous controversy, there is still no agreement on the significance of antimicrobial use in animals and/or resistance in bacterial isolates from animals on the development and dissemination of antibiotic resistance among human bacterial pathogens. Contributing to the controversy is the isolation of bacterial pathogens of animal and human origin that are increasingly resistant to most frontline antibiotics, including third-generation cephalosporins, aminoglycosides, and even fluoroquinolones. Recent studies have demonstrated that the majority of these multiple antimicrobial-resistant phenotypes are obtained by the acquisition of external genes that may provide resistance to an entire class of antimicrobials. A number of these resistance genes have been associated with large, transferable, extrachromosomal DNA elements, called plasmids, on which may be other DNA mobile elements, termed transposons and integrons. These DNA mobile elements that have been shown to possess genetic determinants for several different antimicrobial resistance mechanisms are largely responsible for the rapid dissemination of resistance genes among different bacterial genera and species. Although the impact of a dairy practitioner or producer may seem small with regards to the emergence and dissemination of bacterial antimicrobial resistance, it is critical that we understand the importance of appropriate antimicrobial therapy from a broader perspective in the dairy production environment.
KW - antibiotics
KW - drug resistance
KW - public health
KW - resistance mechanisms
KW - transposable elements
KW - zoonoses
KW - DNA insertion elements
KW - insertion elements
KW - insertion sequences
KW - mobile genetic elements
KW - mobile sequences
KW - resistance genes
KW - transposons
KW - zoonotic infections
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013160774&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of increasing iron supplementation on blood lipids in rats.
AU - Whittaker, P.
AU - Chanderbhan, R. F.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 2001///
VL - 86
IS - 5
SP - 587
EP - 592
CY - Wallingford; UK
PB - CAB International
SN - 0007-1145
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street S.W., HFS-236, Washington, DC 20204, USA.
N1 - Accession Number: 20013166536. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 57-88-5, 9011-92-1, 7439-89-6. Subject Subsets: Human Nutrition
N2 - The effects of increasing levels of Fe on serum fatty acids, cholesterol, triacylglycerol, liver and heart were examined in male Sprague-Dawley rats fed either Fe-deficient or carbonyl Fe-supplemented diets with 35 (control), 350, 3500 and 20 000 µg Fe/g for 12 weeks. As intake of Fe increased, serum total cholesterol increased from 2.0 mmol/litre in controls to 5.2 mmol/litre at the highest level of Fe. Also, the total serum phospholipid fatty acids increased from 609 mg/dl in controls to 1292 mg/litre at the highest level of Fe. Except for the highest dose of Fe, the ratio of saturated to unsaturated phospholipid fatty acids increased from 1.2 to 1.7. The serum total free fatty acid levels remained constant among all groups with a range from 162 to 228 mg/litre, while a ratio of 0.6 to 0.8 for saturated to unsaturated fatty acids was maintained. A dose-related increase in liver non-haem Fe from 18 to 3500 µg/g correlated with increases in lipid peroxidation (r 0.87), measured by the lipid-conjugated diene assay. Oxidative changes in the liver may have resulted in alterations in sterol synthesis, leading to increased serum cholesterol levels with increases in serum phospholipids and changes in the ratios of their saturated to unsaturated fatty acids. Animals with heart damage showed myocardial degeneration and cardiomyopathy with haemosiderin in interstitial macrophages or myocardial fibres, and when these were coupled with the findings of increased non-haem Fe in the heart and lipid peroxidation in the liver, it is suggested that oxidative stress is involved in the pathogenesis of the lesions.
KW - blood lipids
KW - cardiomyopathy
KW - cholesterol
KW - diets
KW - fatty acids
KW - haemosiderin
KW - heart
KW - intake
KW - iron
KW - laboratory animals
KW - lipid peroxidation
KW - liver
KW - phospholipids
KW - saturated fatty acids
KW - triacylglycerols
KW - unsaturated fatty acids
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hemosiderin
KW - triglycerides
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013166536&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunoassay for viable Cryptosporidium parvum oocysts in turbid environmental water samples.
AU - Call, J. L.
AU - Arrowood, M.
AU - Xie LongTi
AU - Hancock, K.
AU - Tsang, V. C. W.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2001///
VL - 87
IS - 1
SP - 203
EP - 210
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Call, J. L.: Public Health Service, U.S. Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
N1 - Accession Number: 20013043176. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology
N2 - C. parvum oocysts in drinking water have been implicated in outbreaks of diarrhoeal disease. Current methods for monitoring environmental exposures to C. parvum only account for total number of oocysts without regard for the viability of the parasite. Measurement of oocyst viability, as indicated by an oocyst's ability to excyst, is useful because over time oocysts lose the ability to excyst and become noninfective. Thus, correlating the number of viable oocysts in drinking water with incidence and risk for disease should be more reliable than using the total number of oocysts. We have developed a quantitative assay capable of detecting low numbers of excystable, sporozoite-releasing C. parvum oocysts in turbid water samples. Monoclonal (CP7) and polyclonal antibodies have been developed against a sporozoite antigen released only during excystation or when the oocyst is mechanically disrupted. CP7 is specific for C. parvum and does not react with C. baileyi, C.muris, C. serpentis, Giardia spp., Eimeria spp., or E. nieschulzi. In this assay, oocysts in the test sample are first excysted and then centrifuged. The soluble sporozoite antigen is captured by CP7 attached to a magnetic bead. The captured antigen is then detected by ruthenium-labelled polyclonal antibodies via electrochemiluminescence. The CP7 viability assay can detect as few as 50 viable oocysts in a 1-ml assay sample with a turbidity as high as 200 Nephelometric turbidity units. This sensitive, turbidity-tolerant assay for oocyst viability may permit a better assessment of the disease risk associated with the presence of environmental oocysts.
KW - antigens
KW - detection
KW - drinking water
KW - excystation
KW - human diseases
KW - immunoassay
KW - monoclonal antibodies
KW - oocysts
KW - sporozoites
KW - techniques
KW - turbidity
KW - viability
KW - waterborne diseases
KW - Cryptosporidium parvum
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antigenicity
KW - excystment
KW - immunogens
KW - polyclonal antibodies
KW - Water Resources (PP200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation of a strain of Plasmodium vivax from India to New World monkeys, chimpanzees, and anopheline mosquitoes.
AU - Sullivan, J. S.
AU - Strobert, E.
AU - Yang, C. F.
AU - Morris, C. L.
AU - Galland, G. G.
AU - Richardson, B. B.
AU - Bounngaseng, A.
AU - Kendall, J.
AU - McClure, H.
AU - Collins, W. E.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2001///
VL - 87
IS - 6
SP - 1398
EP - 1403
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Sullivan, J. S.: Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 20023020578. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2 - A strain of Plasmodium vivax from India was adapted to develop in splenectomized Saimiri boliviensis, Aotus lemurinus griseimembra, A. vociferans, A. nancymai, A. azarae boliviensis, hybrid Aotus monkeys, and splenectomized chimpanzees. Infections were induced via the inoculation of sporozoites dissected from the salivary glands of Anopheles stephensi and Anopheles dirus mosquitoes to 12 Aotus and 8 Saimiri monkeys; transmission via the bites of infected Anopheles stephensi was made to one Aotus monkey and one chimpanzee. The intravenous passage of infected erythrocytes was made to 9 Aotus monkeys and 4 chimpanzees. Gametocytes in 13 Aotus monkeys and 4 chimpanzees were infectious to mosquitoes. Infection rates were markedly higher in mosquitoes fed on chimpanzees. PCR studies on 10 monkeys injected with sporozoites revealed the presence of parasites before their detection by microscopic examination. The India VII strain of P. vivax develops in Aotus and Saimiri monkeys and chimpanzees following the injection of parasitized erythrocytes, or sporozoites, or both. The transmission rate via sporozoites to New World monkeys of approximately 50% may be too low for the testing of sporozoite vaccines or drugs directed against the exoerythrocytic stages. However, the strain is highly infectious to commonly available laboratory-maintained anopheline mosquitoes. Mosquito infection is especially high when feedings are made with gametocytes from splenectomized chimpanzees.
KW - adaptation
KW - erythrocytes
KW - gametocytes
KW - infection
KW - salivary glands
KW - sporozoites
KW - strains
KW - India
KW - Anopheles dirus
KW - Anopheles stephensi
KW - Aotus
KW - Aotus azarae
KW - Aotus lemurinus
KW - Aotus nancymai
KW - Aotus vociferans
KW - chimpanzees
KW - Culicidae
KW - Plasmodium vivax
KW - Saimiri boliviensis
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pan
KW - Pongidae
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - Aotus azarae boliviensis
KW - Aotus azarai
KW - Aotus lemurinus griseimembra
KW - blood red cells
KW - mosquitoes
KW - red blood cells
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiologic trends in the hospitalization of elderly medicare patients for pneumonia, 1991-1998.
AU - Baine, W. B.
AU - Yu, W.
AU - Summe, J. P.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001///
VL - 91
IS - 7
SP - 1121
EP - 1123
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Baine, W. B.: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Department of Health and Human Services, 6010 Executive Blvd, Rockville, MD 20852-3813, USA.
N1 - Accession Number: 20013113016. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - This study determined hospitalization rates of elderly Americans for pneumonia from 1991 through 1998. Epidemiological data were described for 273 143 pneumonia hospitalizations. Annual hospitalizations for aspiration pneumonia increased by 93.5%. Pneumonia hospitalization rates increased steeply with age, especially among men. Black men were at highest risk for aspiration, unspecified, Klebsiella, "other Gram-negative," and staphylococcal pneumonia; White men had the highest Haemophilus and pneumococcal pneumonia rates. Among women, Blacks predominated in aspiration and Klebsiella pneumonia; Whites had the highest Haemophilus and bronchopneumonia rates. An epidemic of hospitalization for aspiration pneumonia smouldered over 8 years. Significant disparities existed in hospitalization risks by race, sex, and principal diagnosis.
KW - age
KW - bacterial pneumonia
KW - blacks
KW - elderly
KW - epidemiology
KW - Gram negative bacteria
KW - human diseases
KW - men
KW - pneumonia
KW - races
KW - respiratory diseases
KW - trends
KW - women
KW - USA
KW - Bacteria
KW - Haemophilus
KW - Klebsiella
KW - man
KW - Staphylococcus
KW - Streptococcus pneumoniae
KW - Bacteria
KW - prokaryotes
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - bacterium
KW - elderly people
KW - lung diseases
KW - older adults
KW - senior citizens
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved method for the recovery of hepatitis A virus from oysters.
AU - Mullendore, J. L.
AU - Sobsey, M. D.
AU - Shieh, Y. S. C.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2001///
VL - 94
IS - 1/2
SP - 25
EP - 35
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Mullendore, J. L.: US Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20013069271. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Soyabeans; Animal Breeding
N2 - Hepatitis A is one of the major infectious diseases epidemiologically associated with worldwide shellfish consumption. Molecular detection using polymerase chain reaction (PCR) to detect hepatitis A virus (HAV) in contaminated shellfish can be hindered by low virus recoveries during the concentration process and by natural PCR inhibitors in shellfish. This study evaluated and modified two major steps of a processing procedure for virus concentration from oysters: acid adsorption-elution and solvent extraction. With the addition of second and third elutions, the acid adsorption-elution step doubled the recovery to 46% of HAV seeded initially. Extraction with chloroform or chloroform-butanol resulted in lower HAV detection limits by reverse transcription-PCR (RT-PCR)-oligoprobing than extraction with the fluorocarbon, Freon. These results led to the following modified procedure: HAV was acid adsorbed at pH 4.8, eluted first with 0.05 M glycine, second with 0.5 M threonine, PEG-precipitated twice, chloroform-extracted twice, RNA-extracted, and RT-PCR (single round) amplified. Using the modified procedure, HAV was detected by RT-PCR in all trials with a seeding density of ≥1 plaque forming unit (PFU)/g of oyster, and in which the equivalent detection limit was 0.33 PFU of HAV seeded per RT-PCR reaction (corresponding to 111 PCR units). The method developed is capable of detecting low levels of HAV in oysters environmentally contaminated.
KW - detection
KW - methodology
KW - oysters
KW - polymerase chain reaction
KW - hepatitis A virus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - methods
KW - PCR
KW - Aquatic Biology and Ecology (MM300)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lack of induction of interleukin-2-receptor-α in patients with tuberculosis and human immunodeficiency virus co-infection: implications for pathogenesis.
AU - Lawn, S. D.
AU - Rudolph, D.
AU - Ackah, A.
AU - Coulibaly, D.
AU - Wiktor, S.
AU - Lal, R. B.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 2001///
VL - 95
IS - 4
SP - 449
EP - 452
CY - London; UK
PB - Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
AD - Lawn, S. D.: Tuberculosis/Mycobacteriology, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20013134988. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 102524-44-7, 85898-30-2.
N2 - Since expression of both interleukin-2 (IL-2) and IL-2-receptor-α (IL-2R-α) by lymphocytes in inhibited by human immunodeficiency virus (HIV) in vitro, we hypothesized that HIV-co-infection among persons with tuberculosis (TB) might impair T-lymphocyte responses to TB via this mechanism. We measured soluble IL-2R-α (sIL-2R-α), a surrogate marker of T-lymphocyte activation and proliferation, and soluble tumour necrosis factor receptor I (sTNF-RI) in sera from West African patients categorized into 4 groups: those with TB alone (TB+HIV-, n=55), CD4-matched groups with TB and HIV co-infection (TB+HIV+, n=50) or HIV infection alone (TB-HIV+, n=35), and patients with neither disease (TB-HIV-, n=35). The median level of sIL-2R-α was markedly greater in the TB+HIV-group (1580 U/mL) compared to the TB-HIV- (670 U/mL; P<0.001) and TB-HIV+ (880 U/mL; P<0.01) groups. More importantly, the median concentration of sIL-2R-α was much lower in the TB+HIV+ group (855 U/mL) compared to the TB+HIV- group (1580 U/mL; P<0.01) despite similar levels of sTNF-RI. These results suggest that T-lymphocyte activation in TB patients is impaired by HIV co-infection and, furthermore, this suppressive effect was independent of numerical depletion of CD4 lymphocytes. Impairment to IL-2-signalling might contribute to the profound impact that HIV has had on both the incidence and the clinicopathological manifestations of TB.
KW - CD4+ lymphocytes
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunity
KW - immunocompromised hosts
KW - interleukin 2
KW - opportunistic infections
KW - pathogenesis
KW - T lymphocytes
KW - tuberculosis
KW - man
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - CD4+ cells
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - T cells
KW - T4 lymphocytes
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A recombinant particulate antigen of Japanese encephalitis virus produced in stably-transformed cells is an effective noninfectious antigen and subunit immunogen.
AU - Hunt, A. R.
AU - Cropp, C. B.
AU - Chang, G. J. J.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2001///
VL - 97
IS - 1/2
SP - 133
EP - 149
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Hunt, A. R.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 20013127131. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 308067-58-5, 25322-68-3. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - A COS-1 cell line, stably transformed by a plasmid encoding the premembrane and envelope glycoproteins of Japanese encephalitis virus, produced a noninfectious recombinant antigen expressed as extracellular particles. Extracellular particles purified by equilibrium density centrifugation in sucrose gradients followed by electron microscopy were characterized as spherical particles with an average diameter of approximately 30 nm and a buoyant density of 1.15 g/cc. Purified extracellular particles were shown by western blot to contain premembrane, membrane and envelope proteins. The gradient-purified particles exhibited haemagglutination activity at the same pH optimum (6.6) as Japanese encephalitis virus. Recombinant antigen from cell culture fluid was concentrated by precipitation with polyethylene glycol and evaluated for immunogenicity in 8-10-week-old ICR mice. Groups of 5 mice received only one immunization of recombinant antigen with or without Freund's incomplete adjuvant. Mice immunized with recombinant antigen plus Freund's incomplete adjuvant elicited the highest anti-viral titres as determined by both ELISA and plaque-reduction neutralization tests. The polyethylene glycol-concentrated recombinant antigen was also evaluated for use in IgM antibody-capture ELISA and indirect IgG ELISA. The IgM-capture ELISA results using recombinant antigen correlated well with the results of a similar test using Japanese encephalitis virus-infected mouse brain antigen for the analysis of serum samples from patients with symptoms of acute encephalitis. Similar IgG titres were observed in an indirect ELISA comparing recombinant antigen and purified Japanese encephalitis virus as plate-bound antigens. Based on these studies, this entirely safe, easily produced antigen that expresses authentic Japanese encephalitis virus envelope glycoprotein would provide an excellent alternative to standard viral antigens used in various ELISA formats.
KW - antibodies
KW - antigens
KW - envelope proteins
KW - glycoproteins
KW - haemagglutination
KW - human diseases
KW - IgG
KW - IgM
KW - plasmids
KW - polyethylene glycol
KW - surface proteins
KW - Japanese encephalitis virus
KW - man
KW - mice
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - antigenicity
KW - hemagglutination
KW - immunogens
KW - membrane proteins
KW - polyoxyethylene
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An assessment of thimerosal use in childhood vaccines.
AU - Ball, L. K.
AU - Ball, R.
AU - Pratt, R. D.
JO - Pediatrics
JF - Pediatrics
Y1 - 2001///
VL - 107
IS - 5
SP - 1147
EP - 1154
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Ball, L. K.: Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063025546. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 593-74-8, 54-64-8. Subject Subsets: Public Health
N2 - Background. On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here. Methods. The risk assessment consisted of hazard identification, dose-response assessment, exposure assessment, and risk characterization. The literature was reviewed to identify known toxicity of thimerosal, ethylmercury (a metabolite of thimerosal) and methylmercury (a similar organic mercury compound) and to determine the doses at which toxicity occurs. Maximal potential exposure to mercury from vaccines was calculated for children at 6 months old and 2 years, under the US childhood immunization schedule, and compared with the limits for mercury exposure developed by the Environmental Protection Agency (EPA), the Agency for Toxic Substance and Disease Registry, the Food and Drug Administration, and the World Health Organization. Results. Delayed-type hypersensitivity reactions from thimerosal exposure are well-recognized. Identified acute toxicity from inadvertent high-dose exposure to thimerosal includes neurotoxicity and nephrotoxicity. Limited data on toxicity from low-dose exposures to ethylmercury are available, but toxicity may be similar to that of methylmercury. Chronic, low-dose methylmercury exposure may cause subtle neurologic abnormalities. Depending on the immunization schedule, vaccine formulation, and infant weight, cumulative exposure of infants to mercury from thimerosal during the first 6 months of life may exceed EPA guidelines. Conclusion. Our review revealed no evidence of harm caused by doses of thimerosal in vaccines, except for local hypersensitivity reactions. However, some infants may be exposed to cumulative levels of mercury during the first 6 months of life that exceed EPA recommendations. Exposure of infants to mercury in vaccines can be reduced or eliminated by using products formulated without thimerosal as a preservative.
KW - adverse effects
KW - children
KW - exposure
KW - human diseases
KW - hypersensitivity
KW - immunization
KW - infants
KW - methylmercury
KW - nephrotoxicity
KW - neurotoxicity
KW - risk assessment
KW - thiomersal
KW - toxicity
KW - vaccination
KW - vaccines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - allergic responses
KW - ethylmercury
KW - hypersensitiveness
KW - immune sensitization
KW - merthiolate
KW - sodium ethylmercurithiosalicylate
KW - thimerosal
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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UR - http://pediatrics.aappublications.org/cgi/content/abstract/107/5/1147
UR - email: balll@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioaerosol lung damage in a worker with repeated exposure to fungi in a water-damaged building.
AU - Trout, D.
AU - Bernstein, J.
AU - Martinez, K.
AU - Biagini, R.
AU - Wallingford, K.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2001///
VL - 109
IS - 6
SP - 641
EP - 644
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Trout, D.: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 676 Columbia Parkway, R-10, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20013113381. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - This paper reports the case of a 48-year-old worker [Ohio, USA] with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. He presented to his physician in July 1998 with a 2-month history of dry cough and a 1-week history of fever and dyspnoea. Environmental tests were performed to evaluate potential exposure to fungi, and mycotoxin-specific IgG antibody was used in serological studies to evaluate exposure to mycotoxins. Extensive fungal contamination was documented in many areas of the building. Penicillium, Aspergillus, and Stachybotrys species were the most predominant fungi found in air sampling. Serological tests were not useful in differentiating workers who were probably occupationally exposed to mycotoxins from those who were not; however, it did yield evidence that individuals may make specific IgG antibodies to macrocyclic tricothecene mycotoxins. In the absence of clinical tools specific for evaluation of mycotoxin-related illness, a systematic clinical approach for evaluating persons with suspected building-related respiratory illness is warranted.
KW - aerosols
KW - case reports
KW - exposure
KW - human diseases
KW - lungs
KW - mycotoxins
KW - occupational hazards
KW - respiratory diseases
KW - trichothecenes
KW - Ohio
KW - USA
KW - Aspergillus
KW - man
KW - Penicillium
KW - Stachybotrys
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Hypocreales
KW - Sordariomycetes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
AU - Schnorr, T. M.
AU - Lawson, C. C.
AU - Whelan, E. A.
AU - Dankovic, D. A.
AU - Deddens, J. A.
AU - Piacitelli, L. A.
AU - Reefhuis, J.
AU - Sweeney, M. H.
AU - Connally, L. B.
AU - Fingerhut, M. A.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2001///
VL - 109
IS - 11
SP - 1127
EP - 1132
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Schnorr, T. M.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20013179548. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Weeds; Public Health
N2 - There is conflicting research regarding an association between fetal death and paternal exposure to Agent Orange, a phenoxy herbicide widely used in Vietnam that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Men who worked in the U.S. factories that produced Agent Orange were exposed to TCDD at levels hundreds of times higher than TCDD levels in the general population. Wives of TCDD-exposed chemical workers and wives of nonexposed neighbourhood referents were interviewed to determine reproductive history [USA]. Paternal serum TCDD level at time of conception was estimated for each pregnancy using serum samples taken in 1987. Estimated TCDD levels of workers during or after exposure were high (median, 254 ppt; range, 3-16 340 ppt) compared to referent levels (median, 6 ppt; range, 2-19 ppt). No association between paternal TCDD level at the time of conception and spontaneous abortion was observed among pregnancies fathered by workers with TCDD levels of <20 ppt (odds ratio (OR)=0.77; 95% confidence interval (CI), 0.48-1.22), 20 to <255 ppt (OR=0.81; 95% CI, 0.40-1.63), 255 to <1120, (OR=0.69; 95% CI, 0.30-1.58), and ≥1120 ppt (OR=0.95; 95% CI, 0.42-2.17) compared to pregnancies fathered by referents. The sex ratio (males/males+females) of offspring also did not differ by TCDD exposure (0.53 and 0.54 among workers and referents, respectively). We did not find an association between paternal serum TCDD level and spontaneous abortion or sex ratio of offspring in this population. The estimated TCDD levels in this exposed worker population were much higher than in other studies, providing additional evidence that paternal TCDD exposure does not increase the risk of spontaneous abortion at levels above those observed in the general population. The study could not evaluate the effect of father's childhood or prenatal TCDD exposure on subsequent sex ratio.
KW - chemical workers
KW - children
KW - conception
KW - exposure
KW - factory workers
KW - fathers
KW - fetal death
KW - housewives
KW - neighbourhoods
KW - occupational hazards
KW - occupations
KW - phenoxy herbicides
KW - pregnancy
KW - risk
KW - sex ratio
KW - spontaneous abortion
KW - women
KW - Ohio
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - foetal death
KW - gestation
KW - miscarriage
KW - neighborhoods
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013179548&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fumonisin B1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice.
AU - Howard, P. C.
AU - Eppley, R. M.
AU - Stack, M. E.
AU - Warbritton, A.
AU - Voss, K. A.
AU - Lorentzen, R. J.
AU - Kovach, R. M.
AU - Bucci, T. J.
A2 - Allaben, W. T.
A2 - Bucher, J. R.
A2 - Howard, P. C.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2001///
VL - 109
SP - 277
EP - 282
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Howard, P. C.: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., HFT-110, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013119165. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Fumonisin B1 (FB1) is a mycotoxin isolated from Fusarium fungi that contaminate crops worldwide. A previous study demonstrated that FB1 promoted preneoplastic foci in initiated rats and induced hepatocellular carcinomas in BD IX rats at 50 parts per million (ppm), but fundamental dose-response data were not available to assist in setting regulatory guidelines for this mycotoxin. To provide this information, female and male F344/N/Nctr BR rats and B6C3F1/Nctr BR mice were fed for two years a powdered NIH-31 diet containing the following concentrations of FB1: female rats, 0, 5, 15, 50, and 100 ppm; male rats, 0, 5, 15, 50, and 150 ppm; female mice, 0, 5, 15, 50, and 80 ppm; male mice, 0, 5, 15, 80, and 150 ppm. FB1 was not tumorigenic in female F344 rats with doses as high as 100 ppm. Including FB1 in the diets of male rats induced renal tubule adenomas and carcinomas in 0/48, 0/40, 9/48, and 15/48 rats at 0, 5, 15, 50, and 150 ppm, respectively. Including up to 150 ppm FB1 in the diet of male mice did not affect tumour incidence. Hepatocellular adenomas and carcinomas were induced by FB1 in the female mice, occurring in 5/47, 3/48, 1/48, 19/47, and 39/45 female mice that consumed diets containing 0, 5, 15, 50, and 80 ppm FB1, respectively. This study demonstrates that FB1 is a rodent carcinogen that induces renal tubule tumors in male F344 rats and hepatic tumors in female B6C3F1 mice.
KW - carcinogenesis
KW - carcinogens
KW - diets
KW - fumonisins
KW - kidney diseases
KW - kidneys
KW - liver
KW - liver cancer
KW - liver diseases
KW - neoplasms
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - kidney disorders
KW - nephropathy
KW - renal cancer
KW - renal diseases
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013119165&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat.
AU - Howard, P. C.
AU - Warbritton, A.
AU - Voss, K. A.
AU - Lorentzen, R. J.
AU - Thurman, J. D.
AU - Kovach, R. M.
AU - Bucci, T. J.
A2 - Allaben, W. T.
A2 - Bucher, J. R.
A2 - Howard, P. C.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2001///
VL - 109
SP - 309
EP - 314
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Howard, P. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., HFT-110, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013119174. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 59 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Fumonisin B1 (FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme [Gibberella fujikuroi]), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ppm or higher concentrations induced renal tubule carcinomas in male F344/N/Nctr BR rats and hepatocellular carcinomas in female B6C3F1/Nctr BR mice. The carcinogenicity of FB1 in rats and mice is not due to DNA damage, as several laboratories have demonstrated that FB1 is not a genotoxin. FB1 induces apoptosis in cells in vitro. Including FB1 in the diets of rats results in increased hepatocellular and renal tubule epithelial cell apoptosis. In studies with F344/N/Nctr BR rats consuming diets containing up to 484 ppm FB1 for 28 days, female rats demonstrated more sensitivity than male rats in the induction of hepatocellular apoptosis and mitosis. Conversely, induction of renal tubule apoptosis and regeneration were more pronounced in male than in female rats. Induction of renal tubule apoptosis and hyperplasia correlated with the incidence of renal tubule carcinomas that developed in the 2-year feeding study with FB1 in the F344/N/Nctr BR rats. The data are consistent with the hypothesis that the induction of renal tubule carcinomas in male rats could be partly due to the continuous compensatory regeneration of renal tubule epithelial cells in response to the induction of apoptosis by fumonisin B1.
KW - apoptosis
KW - carcinogenesis
KW - food contamination
KW - food intake
KW - fumonisins
KW - hyperplasia
KW - kidneys
KW - laboratory animals
KW - neoplasms
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - food contaminants
KW - renal cancer
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013119174&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The immunodominant 17-kDa antigen from Cryptosporidium parvum is glycosylphosphatidylinositol-anchored.
AU - Priest, J. W.
AU - Xie LongTi
AU - Arrowood, M. J.
AU - Lammie, P. J.
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
Y1 - 2001///
VL - 113
IS - 1
SP - 117
EP - 126
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0166-6851
AD - Priest, J. W.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Mail Stop F-13, Building 23, Room 1025, 4770 Buford Highway N.E., Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20013043873. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 141-43-5, 87-89-8. Subject Subsets: Protozoology
N2 - Cryptosporidium parvum is a protozoan parasite of the intestinal epithelium that has caused numerous outbreaks of diarrhoeal illness in humans. During our studies of the host immune response to C. parvum infection, we noted that 2 of the immunodominant surface antigens of the sporozoite stage of the parasite readily extract into Triton X-114. We recently cloned the immunodominant 17-kDa surface antigen and suggested that the carboxy-terminal peptide sequence may satisfy the requirements for GPI anchor addition. In the work presented here, we were able to show that the 17-kDa antigen could be metabolically labelled in vitro with tritiated ethanolamine and that the antigen contained myo-inositol. The antigen was cleaved by GPI-PLD but not by PI-PLC and it could be converted to a water soluble form by chemical deglycosylation. We suggest that the 17-kDa antigen is indeed GPI anchored and that the anchor contains an acylated inositol and either a lyso-acyl- or a diacyl-glycerol.
KW - biochemistry
KW - cryptosporidiosis
KW - ethanolamine
KW - human diseases
KW - myo-inositol
KW - phosphatidylinositols
KW - surface antigens
KW - Cryptosporidium parvum
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - glycosylphosphatidylinositol
KW - inositol
KW - meso-inositol
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013043873&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Arsenic extraction and speciation in carrots using accelerated solvent extraction, liquid chromatography and plasma mass spectrometry.
AU - Vela, N. P.
AU - Heitkemper, D. T.
AU - Stewart, K. R.
JO - Analyst
JF - Analyst
Y1 - 2001///
VL - 126
IS - 7
SP - 1011
EP - 1017
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 0003-2654
AD - Vela, N. P.: US Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20013100311. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 7440-38-2, 75-60-5. Subject Subsets: Human Nutrition; Postharvest Research; Horticultural Science
N2 - Arsenic present in freeze-dried carrots was extracted using accelerated solvent extraction (ASE). Several parameters, including selection of the dispersing agent, extraction time, number of extraction cycles, particle size and extraction temperature, were evaluated to optimize the ASE method. Filtering and treatment with C-18 SPE cartridges were also evaluated as part of the sample preparation procedure before speciation analysis. The method was validated by spiking single arsenical and mixed arsenical standards on the dispersing agent and on portions of freeze-dried carrot prior to extraction. LC-ICP-MS was used to determine individual arsenic species in the carrot extracts. A weak anion-exchange column was used for the separation of As(III), As(V), monomethylarsonic acid (MMA), dimethylarsinic acid and arsenobetaine. Optimized sample preparation conditions were applied to the extraction of arsenic in nine freeze-dried carrot samples. Total arsenic concentration in the carrot samples ranged from less than 20 ng g-1 to 18.7 µg g-1, dry mass. Extraction efficiency, defined as the ratio of the sum of individual arsenic species concentrations to total arsenic, ranged from 80 to 102% for freeze-dried carrots with arsenic concentrations greater than the limit of quantitation. Inorganic As(III) and As(V) were the only species found in samples that contained less than 400 ng g-1 total arsenic. MMA and an unidentified arsenic compound were present in some of the samples with higher total arsenic content.
KW - arsenic
KW - cacodylic acid
KW - carrots
KW - extraction
KW - extracts
KW - freeze drying
KW - methodology
KW - particle size
KW - temperature
KW - Daucus carota
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Araliales
KW - arsenobetaine
KW - dimethylarsinic acid
KW - lyophilization
KW - methods
KW - monomethylarsonic acid
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus.
AU - McMahon, B. J.
AU - Holck, P.
AU - Bulkow, L.
AU - Snowball, M.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2001///
VL - 135
IS - 9
SP - 759
EP - 768
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - McMahon, B. J.: Viral Hepatitis Program, Alaska Native Medical Center, c/o Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, 4055 Tudor Centre Drive, Anchorage, AK 99508-5932, USA.
N1 - Accession Number: 20013163629. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Background: Knowledge of the outcome of chronic hepatitis B virus (HBV) infection is limited. Objective: To determine the incidence of and risk factors for adverse events (hepatocellular carcinoma and end-stage liver disease) and clearance of hepatitis B e antigen (HBeAg) and surface antigen (HBsAg) in carriers of HBV. Design: Population-based cohort study of hepatitis B carriers who were observed for a median of 12.3 years as part of an active surveillance programme to detect carriers with hepatocellular carcinoma. Setting: 126 communities in Alaska (USA). Patients: 1536 Alaska Natives with chronic hepatitis B. Measurements: Bivariate comparisons, multivariable models, and other statistical methods were used to examine the relationships of risk factors to outcomes and clearance of HBeAg and HBsAg. Results: 1536 chronic HBV carriers were followed up for 19 430 person-years from their first HBsAg-positive test result. At the first serologic test, 641 were HBeAg positive and 893 were anti-HBe positive. Older carriers were more likely than younger carriers to clear HBeAg (P<0.001). The observed probability of clearing HBeAg within 10 years of diagnosis was 72.5%. Clearance of HBsAg occurred in 106 (7%) of all carriers and was positively associated with older age and positive result on initial anti-HBe test. The incidence of adverse events was 2.3 per 1000 carrier-years, and the incidence of hepatocellular carcinoma was 1.9 per 1000 carrier-years (2.3 in men and 1.2 in women). Risk for hepatocellular carcinoma increased with age, among those of Yupik Eskimo ethnicity, and among carriers who reverted from anti-HBe to HBeAg. Conclusion: In HBsAg-positive carriers, observed clearance of HBeAg was more than 70% during the first 10 years of follow-up.
KW - age
KW - carcinoma
KW - carrier state
KW - chronic infections
KW - disease course
KW - disease incidence
KW - epidemiology
KW - ethnic groups
KW - hepatitis B
KW - human diseases
KW - Inuit
KW - liver
KW - liver diseases
KW - risk factors
KW - surface antigens
KW - viral antigens
KW - Alaska
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease progression
KW - Eskimos
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human respiratory syncytial virus surface glycoproteins F, G and SH form an oligomeric complex.
AU - Feldman, S. A.
AU - Crim, R. L.
AU - Audet, S. A.
AU - Beeler, J. A.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2001///
VL - 146
IS - 12
SP - 2369
EP - 2383
CY - Wien; Austria
PB - Springer-Verlag Wien
SN - 0304-8608
AD - Feldman, S. A.: Food and Drug Administration, Center for Biologics Evaluation and Research, Laboratory of Pediatrics and Respiratory Viruses, Bethesda, Maryland, USA.
N1 - Accession Number: 20023000017. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 37270-89-6, 9005-49-6, 9041-08-1, 9050-30-0.
N2 - In order to study structural associations, RSV surface glycoproteins were evaluated using heparin agarose affinity chromatography (HAAC). When RSV-infected cell lysate was analysed by HAAC, all 3 surface glycoproteins, (F, G and SH), were eluted. Similarly, when separate lysates from Vero cells infected with vaccinia recombinants expressing F (vvF), G (vvG) and SH (vvSH) proteins were subjected to HAAC, only vvF and vvG expressed proteins bound to heparin, whereas vvSH expressed protein did not bind. When lysates from vvF, vvG and vvSH-infected Vero cells were mixed prior to HAAC, only F and G bound heparin. In contrast, following co-infection of Vero cells with vvF, vvG and vvSH, all 3 proteins were detected subsequent to HAAC. Following HAAC of A2-infected cell lysate and lysate from vvF, vvG and vvSH co-infected Vero cells, 2 high molecular weight complexes of 175 Kd and 210 Kd, respectively, were identified that reacted with anti-F, anti-G and anti-SH antisera. In addition, anti-SH antiserum was able to co-precipitate RSV F, G and SH. Using HAAC and a NaCl step gradient we demonstrated that a fraction of RSV F, G and SH eluted at higher salt concentrations than either purified F or G protein. Taken together, these data suggest that RSV F, G and SH glycoproteins can form an oligomeric complex within infected cells and this complex has a higher affinity for heparin than either G or F protein alone.
KW - envelope glycoproteins
KW - heparin
KW - human diseases
KW - surface proteins
KW - virology
KW - human respiratory syncytial virus
KW - man
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - heparin sulfate
KW - heparin sulphate
KW - membrane proteins
KW - oligomers
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023000017&site=ehost-live&scope=site
UR - email: beeler@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk assessment for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on an epidemiologic study.
AU - Steenland, K.
AU - Deddens, J.
AU - Piacitelli, L.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2001///
VL - 154
IS - 5
SP - 451
EP - 458
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Steenland, K.: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20033067311. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Agricultural Entomology; Public Health
N2 - The International Agency for Research on Cancer (Lyon, France) recently concluded that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a human carcinogen. There have been few human studies and risk assessments with quantitative exposure data. The authors previously conducted exposure-response analyses based on estimated external TCDD exposure for 3538 US male chemical workers and found a positive trend for all cancer with increasing cumulative exposure. In the present study, 1988 data from 170 workers with both estimated external exposure and known serum TCDD levels were used to derive the relation between the two. This derived relation was used to estimate serum TCDD levels over time for all 3538 workers, and new dose-response analyses were conducted by using cumulative serum level. A positive trend (p=0.003) was found between estimated log cumulative TCDD serum level and cancer mortality. For males, the excess lifetime (75 years) risk of dying of cancer given a TCDD intake of 1.0 pg/kg of body weight per day, twice the background intake, was an estimated 0.05-0.9% above a background lifetime risk of cancer death of 12.4%. Data from this cohort are consistent with another epidemiologic risk assessment from Germany and support recent conclusions by the US Environmental Protection Agency.
KW - carcinogens
KW - contaminants
KW - epidemiology
KW - exposure
KW - neoplasms
KW - occupational health
KW - pesticide residues
KW - pollution
KW - surveys
KW - toxic substances
KW - toxicity
KW - France
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - cancers
KW - environmental pollution
KW - poisons
KW - TCDD
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pollution and Degradation (PP600)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033067311&site=ehost-live&scope=site
UR - email: kns1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Economic analysis of a child vaccination project among Asian Americans in Philadelphia, Pa.
AU - Deuson, R. R.
AU - Brodovicz, K. G.
AU - Barker, L.
AU - Zhou, F. J.
AU - Euler, G. L.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2001///
VL - 155
IS - 8
SP - 909
EP - 914
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Deuson, R. R.: National Immunization Program, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20013124002. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - The cost-effectiveness and the benefit-cost ratios of a community-based hepatitis B vaccination catch-up project for Asian American children conducted in Philadelphia, Pennsylvania, USA, from 1 October 1994 to 11 February 1996, were evaluated. The staff in the community-based organizations educated parents about the hepatitis B vaccination, enrolled physicians in the Vaccines for Children programme, and visited homes of children due for a vaccine dose. The staff in the Philadelphia Department of Public Health developed a computerized database, sent reminder letters for children due for a vaccine dose, and offered vaccinations in public clinics, health fairs and homes. A total of 4384 children were included in the programme. The number of children having received 1, 2 or 3 doses of vaccine before and after the interventions, costs incurred by the Philadelphia Department of Public Health and the community-based organizations for design, education and outreach activities, the cost of the vaccination, cost-effectiveness ratios for intermediate outcomes (i.e., per child, per dose, per immunoequivalent patient, and per completed series), discounted cost per discounted year of life saved, and the benefit-cost ratio of the project were assessed. Results revealed that for the completed series of 3 doses, coverage increased by 12 percentage points at a total cost of $268 660 for design, education, outreach and vaccination. Costs per child, per dose and per completed series were $64, $119 and $537, respectively. The discounted cost per discounted year of life saved was $11 525, and 106 years of life were saved through this intervention. The benefit-cost ratio was 4.44:1. Although the increase in coverage was modest, the intervention proved cost-effective and cost-beneficial.
KW - children
KW - community health services
KW - cost benefit analysis
KW - costs
KW - design
KW - education
KW - ethnic groups
KW - hepatitis B
KW - human diseases
KW - immunization
KW - immunization programmes
KW - vaccination
KW - Pennsylvania
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Asian Americans
KW - costings
KW - immune sensitization
KW - immunization programs
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Community Participation and Development (UU450) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - IL-12 induction by a Th1-inducing adjuvant in vivo: dendritic cell subsets and regulation by IL-10.
AU - Huang LiYun
AU - Reis e Sousa, C.
AU - Itoh, Y.
AU - Inman, J.
AU - Scott, D. E.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2001///
VL - 167
IS - 3
SP - 1423
EP - 1430
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Huang LiYun: Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20013123565. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 130068-27-8. Subject Subsets: Protozoology
N2 - IL-12 induction is critical for immune responses against many viruses and intracellular bacterial pathogens. Recent studies suggest that IL-12-secreting dendritic cells (DC) are potent Th1-inducing APC. However, controversy exists concerning the function of DC subsets. Murine studies have suggested that CD8+ DC preferentially induce Th1 responses, whereas CD8- DC induce Th2 development; in this model, different DC subsets prime different responses. Alternatively, the propensity of DC subsets to prime a Th1 response could depend upon the type of initial stimulus. We used a prototypic Th1-inducing adjuvant, heat-killed Brucella abortus (HKBA) to assess stimulation of DC subsets, relationship between Ag burden and IL-12 production, and down-regulation of DC subset IL-12 production by IL-10. In this study, we show that DC were sole producers of IL-12, although most HKBA uptake was by splenic macrophages and granulocytes. More CD8- than CD8+ DC produced IL-12 after HKBA challenge, whereas only CD8+ DC produced IL-12 after injection of another Th1-promoting microbial substance, soluble Toxoplasma gondii Ags. Studies in IL-10-deficient mice revealed that IL-10 down-regulates frequency and duration of IL-12 production by both DC subsets. In the absence of IL-10, IL-12 expression is enabled in CD11clow cells, but not in macrophages or granulocytes. These findings support the concept of DC as the major IL-12 producers in spleens, but challenge the notion that CD8+ and CD8- DC are destined to selectively induce Th1 or Th2 responses, respectively. Thus, the nature of the stimulating substance is important in determining which DC subsets are activated to produce IL-12.
KW - adjuvants
KW - CD8+ lymphocytes
KW - granulocytes
KW - immune response
KW - immunization
KW - interleukin 10
KW - interleukin 12
KW - macrophages
KW - T lymphocytes
KW - vaccination
KW - vaccine development
KW - vaccines
KW - mice
KW - Toxoplasma gondii
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - CD8+ cells
KW - dendrites
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - T8 lymphocytes
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reduction of aflatoxin hazards using ammoniation.
AU - Park, D. L.
AU - Price, W. D.
JO - Reviews of Environmental Contamination and Toxicology
JF - Reviews of Environmental Contamination and Toxicology
Y1 - 2001///
VL - 171
SP - 139
EP - 175
CY - New York; USA
PB - Springer-Verlag New York Inc.
SN - 0179-5953
SN - 0387953027
AD - Park, D. L.: Division of Natural Products, Office of Plant and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20023057948. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 7664-41-7. Subject Subsets: Plant Pathology; Veterinary Science; Medical & Veterinary Mycology; Animal Nutrition
N2 - A review of published reports on the development and evaluation of procedures, specifically ammoniation, for reducing risks associated with aflatoxin contamination in agricultural commodities is presented. Ammonia is used to alter the chemical structure of aflatoxin produced by Aspergillus flavus and Aspergillus parasiticus. Surveillance of domestic and imported agricultural products is discussed. The ammoniation process is described with emphasis on the toxicity of aflatoxin/ammonia reaction products and the effect of ammonia on feed composition and animal performance. The safety of the ammoniation process is indicated by studies on the reduction of aflatoxin B1 levels in animal feeds resulting in the absence of aflatoxin M1 in milk as well as other animal feeding trials. The toxicological or carcinogenic potential of isolated aflatoxin/ammonia reaction products in animal feeds or in food derived from animals fed ammonia-treated, aflatoxin-contaminated feeds is examined.
KW - aflatoxins
KW - ammonia
KW - ammonia treatment
KW - ammoniated feeds
KW - carcinogens
KW - chemical structure
KW - contamination
KW - feeds
KW - food contamination
KW - mycotoxins
KW - reviews
KW - risk reduction
KW - toxic substances
KW - toxicity
KW - Aspergillus flavus
KW - Aspergillus parasiticus
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - ammoniation
KW - feeding stuffs
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - poisons
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Forage and Feed Processing (RR100)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999.
AU - Mounts, A. W.
AU - Hanjeet Kaur
AU - Parashar, U. D.
AU - Ksiazek, T. G.
AU - Cannon, D.
AU - Arokiasamy, J. T.
AU - Anderson, L. J.
AU - Lye, M. S.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2001///
VL - 183
IS - 5
SP - 810
EP - 813
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Mounts, A. W.: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Mailstop G-04, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 20013049009. Publication Type: Journal Article. Corporate Author: USA, Nipah Virus Nosocomial Study Group Language: English. Number of References: 10 ref. Subject Subsets: Tropical Diseases
N2 - During 1998-1999, an outbreak of Nipah virus encephalitis occurred in Malaysia. To assess the possibility of nosocomial transmission, 363 health care workers (HCWs) exposed and 288 HCWs unexposed to outbreak-related patients were surveyed, and their serum samples were tested for anti-Nipah virus antibody [date not given]. These HCWs came from 3 hospitals that had admitted >80% of patients with suspected Nipah virus encephalitis between 26 December 1998 and 30 April 1999. Needlestick injuries were reported by 12 (3%) HCWs, mucosal surface exposure to body fluids by 39 (11%), and skin exposure to body fluids by 89 (25%). No encephalitis occurred in either group. Three exposed and no unexposed HCWs tested positive by EIA for IgG antibodies. It is likely that these 3 were false positives; no IgM response occurred, and the serum samples were negative for anti-Nipah virus neutralizing antibodies. The risk of nosocomial transmission of Nipah virus appears to be low; however, given the high case-fatality rate and the presence of virus in respiratory secretions and urine of some patients, standard and droplet infection-control practices should be maintained with these patients.
KW - disease transmission
KW - encephalitis
KW - health care workers
KW - human diseases
KW - needlestick injuries
KW - nosocomial infections
KW - occupational hazards
KW - occupational health
KW - viral diseases
KW - Malaysia
KW - man
KW - Nipah virus
KW - Paramyxovirinae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Henipavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - ASEAN Countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Threshold Countries
KW - encephalomyelitis
KW - hospital infections
KW - Paramyxovirus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy.
AU - Holman, R. C.
AU - Paddock, C. D.
AU - Curns, A. T.
AU - Krebs, J. W.
AU - McQuiston, J. H.
AU - Childs, J. E.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2001///
VL - 184
IS - 11
SP - 1437
EP - 1444
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Holman, R. C.: Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, MS A-39, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023007814. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 56-75-7. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Epidemiological and clinical characteristics of fatal and nonfatal cases of Rocky Mountain spotted fever (RMSF) were compared to identify the risk factors for death caused by this disease. Confirmed and probable RMSF cases reported through US national surveillance during 1981-98 were analysed. Among 6388 RMSF patients, 213 died (annual case-fatality rate, 3.3%; range, 4.9% in 1982 to 1.1% in 1996). Use of tetracycline-class antibiotics for treatment of RMSF increased significantly in the 1990s, compared with use in the 1980s. Older patients, patients treated with chloramphenicol only, patients for whom tetracycline antibiotics were not the primary therapy, and patients for whom treatment was delayed ≥5 days after the onset of symptoms were at higher risk for death. Although the case-fatality rate was lower in the 1990s than in the 1980s, the risk factors for fatal RMSF were similar. Despite the availability of effective antibiotics, RMSF-related deaths continue to occur because of delayed diagnosis and failure to use appropriate therapy.
KW - antibacterial agents
KW - antibiotics
KW - chloramphenicol
KW - drug therapy
KW - epidemiology
KW - human diseases
KW - mortality
KW - risk assessment
KW - Rocky Mountain spotted fever
KW - tetracyclines
KW - USA
KW - man
KW - Rickettsia rickettsii
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chemotherapy
KW - death rate
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A unique surface membrane anchored purine-salvage enzyme is conserved among a group of primitive eukaryotic human pathogens.
AU - Debrabant, A.
AU - Bastien, P.
AU - Dwyer, D. M.
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
Y1 - 2001///
VL - 220
IS - 1/2
SP - 109
EP - 116
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0300-8177
AD - Debrabant, A.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20013097745. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9033-33-4. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Tropical Diseases
N2 - The gene encoding the 3′-nucleotidase/nuclease (Ld3′NT/NU) from the human pathogen, Leishmania donovani, was previously isolated and characterized. This unique cell surface enzyme has been shown to be involved in the salvage of host-derived purines, which are essential for the survival of this important protozoan parasite. In this report, it was assessed whether the 3′-nucleotidase/nuclease was conserved amongst other pathogenic Leishmania and related trypanosomatid parasites. Results of pulsed field gel electrophoresis and Southern blotting showed that a Ld3′NT/NU gene homologue was present in each of the visceral and cutaneous Leishmania species tested (i.e. isolates of L. donovani, L. infantum, L. tropica, L. major and L. mexicana, respectively). Furthermore, results of colorimetric assays using 3′-adenosine monophosphate as substrate demonstrated that each of thse organisms also expressed significant levels of 3′-nucleotidase enzyme activity. In addition, a Ld3′NT/NU gene homologue was shown to be expressed in each of these Leishmania species as >40 kDa 3′-nucleotidase enzyme activity. A Ld3′NT/NU gene homologue was also identified in two Crithidia species (C. fasciculata and C. luciliae) and Leptomonas seymouri but was only marginally detectable in Trypanosoma brucei, T. cruzi and Phytomonas serpens. Cumulatively, results of this study showed that an Ld3′NT/NU homologue was conserved amongst pathogenic Leishmania sp., which suggests that this enzyme must play an critical role in purine salvage for all members of this group of human pathogens.
KW - enzyme activity
KW - enzymes
KW - gene expression
KW - nucleases
KW - nucleotidase
KW - purines
KW - Crithidia
KW - Leishmania
KW - Leptomonas
KW - man
KW - Trypanosomatidae
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - purine bases
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gene expression profile in response to chromium-induced cell stress in A549 cells.
AU - Ye, J.
AU - Shi, X.
T3 - Special issue. Molecular mechanisms of metal toxicity and carcinogenesis
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
Y1 - 2001///
VL - 222
IS - 1/2
SP - 189
EP - 197
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0300-8177
AD - Ye, J.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20013144066. Publication Type: Journal Article. Note: Special issue. Molecular mechanisms of metal toxicity and carcinogenesis Language: English. Number of References: 64 ref. Registry Number: 7440-47-3, 7440-70-2.
N2 - Chromium (Cr) is a trace element required for life. Biological activities of Cr are complicated and remain to be fully investigated. It is known that the valence of Cr plays an important role in the biological activities of Cr. For example, Cr (VI) is classified as a metal carcinogen, but Cr (III) is widely used as a nutritional supplement. Establishment of a gene expression profile for Cr-induced cellular response is necessary to facilitate investigation of the biological activities of Cr. In the present study, a large-scale gene expression analysis was conducted using RNA of human lung epithelial cells after in vitro exposure to Cr (VI). Utilizing high-density oligonucleotide arrays representing 2400 genes, we observed that expression of 150 genes was up-regulated, and that of 70 genes were down-regulated by Cr (VI). Functional analysis of these responsive genes led to an outline of potential biological activities of Cr in 6 aspects: redox stress, calcium mobilization, energy metabolism, protein synthesis, cell cycle regulation and carcinogenesis in the cell. The results provide a critical clue for understanding the molecular mechanisms of the biological activities of Cr.
KW - calcium
KW - carcinogenesis
KW - carcinogens
KW - cell cycle
KW - cells
KW - chromium
KW - energy metabolism
KW - gene expression
KW - genes
KW - heavy metals
KW - mobilization
KW - neoplasms
KW - oxidative stress
KW - protein synthesis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - protein biosynthesis
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Molecular mechanisms of metal toxicity and carcinogenesis.
AU - Shi, X. L.
AU - Castranova, V.
AU - Vallyathan, V.
AU - Perry, W. G.
A2 - Shi, X. L.
A2 - Castranova, V.
A2 - Vallyathan, V.
A2 - Perry, W. G.
T2 - Molecular and Cellular Biochemistry
T3 - Special issue. Molecular mechanisms of metal toxicity and carcinogenesis
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
Y1 - 2001///
VL - 222
IS - 1/2
SP - 239
EP - 239
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0300-8177
AD - Shi, X. L.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20013144068. Publication Type: Journal issue. Note: Special issue. Molecular mechanisms of metal toxicity and carcinogenesis Language: English.
N2 - This supplement issue presents 26 papers which discusses the latest developments concerning the molecular mechanisms of metal-induced toxicity and carcinogenesis. The presentations cover a wide range of topics, which include: (1) effects of metal on apoptosis and cell growth regulation; (2) mechanism of metal-induced regulation of nuclear transcription factors; (3) activation of signal transduction pathway; (4) effects of metals on gene expression; (5) mechanism of metal-induced cytotoxicity, cellular responses, mutagenesis and carcinogenesis; and, (6) detection and mechanism of metal-induced free radical generation.
KW - apoptosis
KW - carcinogenesis
KW - cell growth
KW - cytotoxicity
KW - free radicals
KW - heavy metals
KW - molecular biology
KW - mutagenesis
KW - signal transduction
KW - toxicity
KW - transcription factors
KW - cell elongation
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.
AU - Syin, C.
AU - Parzy, D.
AU - Traincard, F.
AU - Boccaccio, I.
AU - Joshi, M. B.
AU - Lin, D. T.
AU - Yang, X. M.
AU - Assemat, K.
AU - Doerig, C.
AU - Langsley, G.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 2001///
VL - 268
IS - 18
SP - 4842
EP - 4849
CY - Oxford; UK
PB - Blackwell Science
SN - 0014-2956
AD - Syin, C.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20013129739. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 60-92-4, 9026-43-1. Subject Subsets: Tropical Diseases; Protozoology
N2 - In Plasmodium falciparum, the causative agent of human malaria, the catalytic subunit gene of cAMP-dependent protein kinase (Pfpka-c) exists as a single copy. Interestingly, its expression appears developmentally regulated, being at higher levels in the pathogenic asexual stages than in the sexual forms of parasite that are responsible for transmission to the mosquito vector. Within asexual parasites, PfPKA activity can be readily detected in schizonts. Similar to endogenous PKA activity of noninfected red blood cells, the parasite enzyme can be stimulated by cAMP and inhibited by protein kinase inhibitor. Importantly, ex vivo treatment of infected erythrocytes with the classical PKA-C inhibitor H89 leads to a block in parasite growth. This suggests that the PKA activities of infected red blood cells are essential for parasite multiplication. Finally, structural considerations suggest that drugs targeting the parasite, rather than the erythrocyte enzyme, might be developed that could help in the fight against malaria.
KW - c-AMP
KW - disease control
KW - human diseases
KW - inhibitors
KW - malaria
KW - protein kinase
KW - man
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - cyclic adenosine monophosphate
KW - cyclic AMP
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation of herpes simplex virus gene expression.
AU - Weir, J. P.
JO - Gene
JF - Gene
Y1 - 2001///
VL - 271
IS - 2
SP - 117
EP - 130
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-1119
AD - Weir, J. P.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20013099957. Publication Type: Journal Article. Language: English. Number of References: 124 ref. Subject Subsets: Public Health
KW - cell cycle
KW - gene expression
KW - genes
KW - genetic regulation
KW - herpes simplex
KW - herpes simplex viruses
KW - human herpesviruses
KW - nucleotide sequences
KW - reviews
KW - transcription
KW - viral regulatory proteins
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - DNA sequences
KW - DNA transcription
KW - herpes simplex virus
KW - Human herpesvirus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - West Nile virus.
AU - Craven, R. B.
AU - Roehrig, J. T.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2001///
VL - 286
IS - 6
SP - 651
EP - 653
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Craven, R. B.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Foothills Campus, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 20013122232. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This article discusses the epidemiology, clinical manifestations, diagnosis and treatment of West Nile virus infections. Currently available strategies for surveillance, prevention and control of West Nile virus are also reviewed.
KW - diagnosis
KW - epidemiology
KW - human diseases
KW - viral diseases
KW - West Nile fever
KW - West Nile virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20013122232&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community.
AU - Groom, A. V.
AU - Wolsey, D. H.
AU - Naimi, T. S.
AU - Smith, K.
AU - Johnson, S.
AU - Boxrud, D.
AU - Moore, K. A.
AU - Cheek, J. E.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2001///
VL - 286
IS - 10
SP - 1201
EP - 1205
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Groom, A. V.: National Epidemiology Program, Indian Health Service Headquarters, 5300 Homestead Rd NE, Albuquerque, NM 87110, USA.
N1 - Accession Number: 20013133771. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 61-32-5. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - A retrospective cohort study with medical record review was conducted to document the occurrence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections and evaluate risk factors for community-acquired MRSA infection compared with methicillin-susceptible S. aureus (MSSA) infection in an Indian Health Service facility in Albuquerque, New Mexico, USA. Patients whose medical records indicated laboratory-confirmed S. aureus infection diagnosed during 1997 are included in the study. Proportion of MRSA infections classified as community acquired based on standardized criteria; risk factors for community-acquired MRSA infection compared with those for community-acquired MSSA infection; and relatedness of MRSA strains, determined by pulsed-field gel electrophoresis (PFGE) were measured. Of 112 S. aureus isolates, 62 (55%) were MRSA and 50 (45%) were MSSA. 46 (74%) of the 62 MRSA infections were classified as community acquired. Risk factors for community-acquired MRSA infections were not significantly different from those for community-acquired MSSA. Pulsed-field gel electrophoresis subtyping indicated that 34 (89%) of 38 community-acquired MRSA isolates were clonally related and distinct from nosocomial MRSA isolates found in the region. Community-acquired MRSA may have replaced community-acquired MSSA as the dominant strain in this community. Antimicrobial susceptibility patterns and PFGE subtyping support the finding that MRSA is circulating beyond nosocomial settings in this and possibly other rural US communities.
KW - American indians
KW - antibacterial agents
KW - disease incidence
KW - drug resistance
KW - epidemiology
KW - human diseases
KW - methicillin
KW - risk factors
KW - rural areas
KW - New Mexico
KW - USA
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - bacterium
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The isolation of antibiotic-resistant salmonella from retail ground meats.
AU - White, D. G.
AU - Zhao, S.
AU - Sudler, R.
AU - Ayers, S.
AU - Friedman, S.
AU - Chen, S.
AU - McDermott, P. F.
AU - McDermott, S.
AU - Wagner, D. D.
AU - Meng, J.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2001///
VL - 345
IS - 16
SP - 1147
EP - 1154
CY - Waltham; USA
PB - Massachusetts Medical Society
SN - 0028-4793
AD - White, D. G.: Division of Animal and Food Microbiology Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20013151010. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 738-70-5. Subject Subsets: Public Health; Pig Science; Poultry; Human Nutrition; Veterinary Science; Veterinary Science
N2 - Background: Salmonella is a leading cause of food-borne illness. The emergence of antimicrobial-resistant salmonella is associated with the use of antibiotics in animals raised for food; resistant bacteria can be transmitted to humans through foods, particularly those of animal origin. We identified and characterized strains of Salmonella isolated from ground meats purchased in the Washington, District of Columbia, USA, area between June and September 1998. Methods: Salmonella was isolated from samples of ground chicken, beef, turkey, and pork purchased at three supermarkets. The isolates were characterized by serotyping, antimicrobial-susceptibility testing, phage typing, and pulsed-field gel electrophoresis. The polymerase chain reaction and DNA sequencing were used to identify resistance integrons and extended spectrum β-lactamase genes. Results: Of 200 meat samples, 41 (20 percent) contained Salmonella, with a total of 13 serotypes. Eighty-four percent of the isolates were resistant to at least one antibiotic, and 53 percent were resistant to at least three antibiotics. Sixteen percent of the isolates were resistant to ceftriaxone, the drug of choice for treating salmonellosis in children. Bacteriophage typing identified four isolates of Salmonella enterica serotype typhimurium definitive type 104 (DT104), one of DT104b, and two of DT208. Five isolates of S. enterica serotype agona had resistance to 9 antibiotics, and the two isolates of serotype typhimurium DT208 were resistant to 12 antibiotics. Electrophoretic patterns of DNA that were indistinguishable from one another were repeatedly found in isolates from different meat samples and different stores. Eighteen isolates, representing four serotypes, had integrons with genes conferring resistance to aminoglycosides, sulfonamides, trimethoprim, and β-lactams. Conclusions: Resistant strains of Salmonella are common in retail ground meats. These findings provide support for the adoption of guidelines for the prudent use of antibiotics in food animals and for a reduction in the number of pathogens present on farms and in slaughterhouses. National surveillance for antimicrobial-resistant Salmonella should be extended to include retail meats.
KW - aminoglycoside antibiotics
KW - beef
KW - beta-lactam antibiotics
KW - chicken meat
KW - drug resistance
KW - food contamination
KW - genes
KW - meat
KW - microbial contamination
KW - pigmeat
KW - poultry
KW - strains
KW - sulfonamides
KW - trimethoprim
KW - turkey meat
KW - District of Columbia
KW - USA
KW - fowls
KW - Salmonella
KW - Salmonella typhimurium
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - pork
KW - sulphonamides
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Congestive heart failure associated with itraconazole.
AU - Ahmad, S. R.
AU - Singer, S. J.
AU - Leissa, B. G.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 2001///
VL - 357
IS - 9270
SP - 1766
EP - 1767
CY - London; UK
PB - Lancet Limited
SN - 0140-6736
AD - Ahmad, S. R.: Office of Postmarketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, HFD-430, Room 15B-08, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20013084923. Publication Type: Journal Article. Language: English. Registry Number: 84625-61-6. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Itraconazole is a synthetic antifungal agent approved in the USA for the treatment of onychomycosis and serious systemic fungal infections. Animal and clinical pharmacology studies suggest negative inotropic effects with itraconazole. Data from the US Food and Drug Administration's Adverse Event Reporting System suggest that use of itraconazole is associated with congestive heart failure. We summarize the details of 58 cases suggestive of congestive heart failure in association with the use of itraconazole in USA, in April 2001. Labelling of itraconazole has been changed to alert physicians to this new finding.
KW - adverse effects
KW - antifungal agents
KW - drug therapy
KW - drug toxicity
KW - heart
KW - heart diseases
KW - human diseases
KW - itraconazole
KW - onychomycosis
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - chemotherapy
KW - congestive heart failure
KW - coronary diseases
KW - fungistats
KW - tinea unguium
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P. carinii pneumonia in patients with HIV-1: a prospective study.
AU - Navin, T. R.
AU - Beard, C. B.
AU - Huang, L.
AU - Rio, C. del
AU - Lee, S.
AU - Pieniazek, N. J.
AU - Carter, J. L.
AU - Le, T.
AU - Hightower, A.
AU - Rimland, D.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 2001///
VL - 358
IS - 9281
SP - 545
EP - 549
CY - London; UK
PB - Lancet Limited
SN - 0140-6736
AD - Navin, T. R.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20013147923. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 8064-90-2. Subject Subsets: Medical & Veterinary Mycology
N2 - Background: Investigators have reported that patients infected with Pneumocystis carinii containing mutations in the DHPS (dihydropteroate synthase) gene have a worse outcome than those infected with P. carinii containing wild-type DHPS. We investigated patients with HIV-1 infection and P. carinii pneumonia to determine if DHPS mutations were associated with poor outcomes in these patients. Methods: We compared presence of mutations at the DHPS locus with survival and response of patients to co-trimoxazole or other drugs. Findings for patients initially given co-trimoxazole, 9 (14%) of 66 with DHPS mutant died, compared with 9 (25%) of 36 with wild type (risk ratio=0.55 (95% CI=0.24-1.25); p=0.15). 10 (15%) of 66 patients with a DHPS mutant did not respond to treatment, compared with 13 (36%) of 36 patients with the wild type (0.42 (0.20-0.86); p=0.02). For patients aged 40 years or older, 4 (14%) of 29 with the mutant and 9 (56%) of 16 with the wild type died (0.25 (0.09-0.67); p=0.005). Interpretation: These results, by contrast with those of previous studies, suggest that patients with wild-type P. carinii do not have a better outcome than patients with the mutant when given co-trimoxazole. Our results suggest that presence of a DHPS mutation should be only one of several criteria guiding the choice of initial drug treatment of P. carinii pneumonia in patients with HIV-1 infection.
KW - antibacterial agents
KW - co-trimoxazole
KW - concurrent infections
KW - disease course
KW - drug therapy
KW - genes
KW - HIV-1 infections
KW - human diseases
KW - immunocompromised hosts
KW - mutations
KW - opportunistic infections
KW - Pneumocystis carinii pneumonia
KW - survival
KW - Human immunodeficiency virus 1
KW - man
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystis carinii
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumocystis
KW - Pneumocystidaceae
KW - Pneumocystidales
KW - Pneumocystidomycetes
KW - Taphrinomycotina
KW - Ascomycota
KW - fungi
KW - chemotherapy
KW - disease progression
KW - fungus
KW - human immunodeficiency virus type 1
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/- human lymphoblastoid cells.
AU - Domon, O. E.
AU - McGarrity, L. J.
AU - Bishop, M.
AU - Yoshioka, M.
AU - Chen, J. J.
AU - Morris, S. M.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2001///
VL - 474
IS - 1/2
SP - 129
EP - 137
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0027-5107
AD - Domon, O. E.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013042454. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Coumestrol, a phytoestrogen found in alfalfa and red clover, was screened for effects against AHH-1 TK+/- human lymphoblastoid cells. Micronuclei were induced with the highest frequency occurring at day 2 of exposure. Flow cytometric analysis of annexin V-FITC-7-aminoactinomycin D-stained cells indicated that the primary pathway of cell death was by apoptosis. Mutations induced in the thymidine kinase gene were due primarily to the induction of clones with the slow-growth phenotype. Subsequent molecular analysis revealed the loss of exon 4 in the coumestrol-induced clones, indicative of loss of heterozygosity and consistent with a proposed inhibition of topoisomerase-II activity as a mechanism of action of coumestrol. Coumestrol exhibits both mutagenic and clastogenic properties.
KW - cell lines
KW - cytotoxic compounds
KW - cytotoxicity
KW - enzyme activity
KW - enzyme inhibitors
KW - mutagenicity
KW - neoplasms
KW - phytochemicals
KW - plant oestrogens
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - carcinogenic properties
KW - phytoestrogens
KW - plant estrogens
KW - topoisomerase
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats.
AU - Khaidakov, M.
AU - Bishop, M. E.
AU - Manjanatha, M. G.
AU - Lyn-Cook, L. E.
AU - Desai, V. G.
AU - Chen, J. J.
AU - Aidoo, A.
T3 - Special issue: Molecular mechanisms of anticarcinogenesis and antimutagenesis
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2001///
VL - 480/481
SP - 163
EP - 170
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0027-5107
AD - Khaidakov, M.: Division of Genetic & Reproductive Toxicology, National Center for Toxicological Research, FDA Jefferson Laboratories, Jefferson, AR 72079, USA.
N1 - Accession Number: 20013129134. Publication Type: Journal Article. Note: Special issue: Molecular mechanisms of anticarcinogenesis and antimutagenesis Language: English. Number of References: 52 ref. Registry Number: 50-81-7, 7235-40-7, 7782-49-2, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Studies on agents that modulate carcinogen-induced genotoxic effects in experimental animals provide end points that can be used for assessing the antimutagenic or anticarcinogenic properties of putative chemopreventive compounds and for predicting their protective efficacy in humans. In this study, we investigated the ability of the dietary antioxidant vitamins C, E, β-carotene and the mineral selenium to inhibit the mutant frequency (MF) induced by treatment of rats with 7,12-dimethylbenz[a]anthracene (DMBA), a mammary carcinogen and bleomycin (BLM), an anti-tumour agent that can damage DNA by free radical mechanisms. Both chemicals have been previously shown to be mutagenic in the rat lymphocyte Hprt assay. Adult female Fischer 344 rats were given the antioxidants singly or in a combination 2 weeks prior to mutagen treatment. Antioxidant intake continued for an additional 4 weeks post-mutagen treatment. At sacrifice, spleens were aseptically removed for the isolation of lymphocytes to conduct the mutagenesis assay at the Hprt locus. The DMBA and BLM treatment induced a marked increase in MF, 52.8 × 10-6 and 19.2 × 10-6, respectively, over the controls. The MFs seen in the individual antioxidants alone (single or mixture) were relatively similar to the controls, with the exception of vitamins C and E, that had 1.7- and 1.5-fold increase, respectively. The degree of inhibitory response was dependent on the type of mutagen and the particular antioxidant. BLM/antioxidant combination had inhibitions ranging from 44 to 80%, whereas DMBA/antioxidant system ranged from 60 to 93%, with vitamins C and E achieving the highest inhibition in both systems. The mixture displayed low inhibitory responses, 44.6% for BLM/mix and 47% DMBA/mix. On the whole, the results indicate that the dietary constituents tested are antimutagenic; however, because of the gradations seen with the responses, the protective efficacy of these antioxidants may depend on the type of mutagen/carcinogen they encounter. Pending molecular analysis of mitochondrial DNA mutations will also indicate whether there is a shift in the mutational spectra produced by the carcinogens in the presence of antioxidants.
KW - antimutagenic properties
KW - antineoplastic agents
KW - antioxidants
KW - ascorbic acid
KW - beta-carotene
KW - carcinogenesis
KW - carcinogens
KW - inhibition
KW - laboratory animals
KW - lymphocytes
KW - mutagenesis
KW - mutagenicity
KW - mutagens
KW - selenium
KW - vitamin E
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-mutagenic properties
KW - cytotoxic agents
KW - vitamin C
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation in the United States.
AU - Firestone, D.
A2 - Rossell, J. B.
T2 - Frying: improving quality
Y1 - 2001///
CY - Cambridge; USA
PB - Woodhead Publishing Ltd
SN - 1855735563
AD - Firestone, D.: Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20013065963. Publication Type: Book chapter. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition
N2 - General guidelines to control the quality of frying fat and the manufacture of fried foods established by the US Food and Drug Administration (FDA) and the US Department of Agriculture/Food Safety and Inspection Service are presented. State and local regulatory agencies have no specific regulations for control of frying fats or frying operations other than the general provisions of the Code of Federal Regulations and the FDA Food Code. Guidelines and advice for handling frying fats from several European countries are also included.
KW - cooking fats
KW - cooking oils
KW - fried foods
KW - frying
KW - guidelines
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - recommendations
KW - United States of America
KW - Food Processing (General) (QQ100)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Bacillus cereus.
AU - Bennett, R. W.
A2 - Labbé, R. G.
A2 - García, S.
T2 - Guide to foodborne pathogens
Y1 - 2001///
CY - New York; USA
PB - John Wiley and Sons
SN - 0471350346
AD - Bennett, R. W.: Division of Microbiology, OSRS, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20023032651. Publication Type: Book chapter. Language: English. Number of References: 14 ref.
N2 - This chapter focuses on the identification and characterization of Bacillus cereus and other Bacillus species associated with foods and food poisoning. The epidemiology, detection, inhibition and inactivation of B. cereus and effective prevention and control measures are discussed.
KW - food poisoning
KW - foods
KW - human diseases
KW - Bacillus cereus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bacillus
KW - bacterium
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Staphylococcus aureus.
AU - Bennett, R. W.
A2 - Labbé, R. G.
A2 - García, S.
T2 - Guide to foodborne pathogens
Y1 - 2001///
CY - New York; USA
PB - John Wiley and Sons
SN - 0471350346
AD - Bennett, R. W.: Division of Microbiology, OSRS, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20023032686. Publication Type: Book chapter. Language: English. Number of References: 21 ref.
N2 - This chapter focuses on foodborne illness associated with Staphylococcus aureus. Symptoms associated with staphylococcal food poisoning, characteristics of S. aureus and properties of enterotoxins are described. Epidemiology, detection and identification methods, and disease prevention and control are discussed.
KW - enterotoxins
KW - epidemiology
KW - food poisoning
KW - foodborne diseases
KW - human diseases
KW - Staphylococcus aureus
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Escherichia coli.
AU - Feng, P.
A2 - Labbé, R. G.
A2 - García, S.
T2 - Guide to foodborne pathogens
Y1 - 2001///
CY - New York; USA
PB - John Wiley and Sons
SN - 0471350346
AD - Feng, P.: Division of Microbiology, OSRS, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20023032666. Publication Type: Book chapter. Language: English. Number of References: 18 ref.
N2 - This chapter examines the general characteristics, disease and epidemiology of Escherichia coli (EC). Methods used for detection, prevention and control of these pathogens in food are discussed. Enterohaemorrhagic EC group, especially serotype O157:H7, is emphasized.
KW - bacterial diseases
KW - enterohaemorrhagic Escherichia coli
KW - foodborne diseases
KW - haemorrhagic colitis
KW - human diseases
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - EHEC
KW - enterohemorrhagic Escherichia coli
KW - hemorrhagic colitis
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023032666&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Parasites.
AU - Jackson, G. J.
A2 - Labbé, R. G.
A2 - García, S.
T2 - Guide to foodborne pathogens
Y1 - 2001///
CY - New York; USA
PB - John Wiley and Sons
SN - 0471350346
AD - Jackson, G. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20023032703. Publication Type: Book chapter. Language: English. Number of References: 19 ref.
N2 - This chapter focuses on the identification of foodborne parasites. Detection methods are evaluated. Diverse substances excreted and secreted by parasites, microbial symbionts of parasitic animals, epidemiology, symptoms of infection and inactivation methods are discussed.
KW - epidemiology
KW - foodborne diseases
KW - human diseases
KW - inactivation
KW - parasites
KW - symbionts
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023032703&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Inactivated vaccines based on alternatives to wild-type seed virus.
AU - Chumakov, K.
AU - Dragunsky, E.
AU - Ivshina, A.
AU - Enterline, J.
AU - Wells, V.
AU - Nomura, T.
AU - Gromeier, M.
AU - Wimmer, E.
A2 - Brown, F.
T2 - Progress in polio eradication: vaccine strategies for the end game. Proceedings of a symposium, Insitut Pasteur, Paris, France, 28-30 June, 2000
T3 - Developments in Biologicals, Vol. 105
Y1 - 2001///
CY - Basel; Switzerland
PB - S Karger AG
SN - 3805572859
AD - Chumakov, K.: Center for Biologics Evaluation and Research, FDA, Division of Viral Products, 1401 Rockville Pike, HEM 255, Rockville, MD 20852, USA.
N1 - Accession Number: 20023058243. Publication Type: Book chapter; Conference paper. Note: Developments in Biologicals, Vol. 105 Language: English. Number of References: 13 ref. Subject Subsets: Agricultural Biotechnology
N2 - New recombinant poliovirus strains that can be used as substrates for inactivated poliovaccine production are described. The advantages of using these recombinant types for poliovaccine development are discussed.
KW - human diseases
KW - immunization
KW - inactivated vaccines
KW - poliomyelitis
KW - recombinant vaccines
KW - vaccination
KW - vaccine development
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - human poliovirus
KW - immune sensitization
KW - killed vaccines
KW - polio
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023058243&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - West Nile virus.
AU - Campbell, G. L.
AU - Marfin, A. A.
AU - Lanciotti, R. S.
AU - Gubler, D. J.
JO - Lancet Infectious Diseases
JF - Lancet Infectious Diseases
Y1 - 2002///
VL - 2
IS - 9
SP - 519
EP - 529
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 1473-3099
AD - Campbell, G. L.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, Colorado, USA.
N1 - Accession Number: 20043026732. Publication Type: Journal Article. Language: English. Number of References: 90 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - West Nile (WN) virus is a mosquito-borne flavivirus and human, equine, and avian neuropathogen. The virus is indigenous to Africa, Asia, Europe, and Australia, and has recently caused large epidemics in Romania, Russia, and Israel. Birds are the natural reservoir (amplifying) hosts, and WN virus is maintained in nature in a mosquito-bird-mosquito transmission cycle primarily involving Culex sp. mosquitoes. WN virus was recently introduced to North America, where it was first detected in 1999 during an epidemic of meningoencephalitis in New York City. During 1999-2002, the virus extended its range throughout much of the eastern parts of the USA, and its range within the western hemisphere is expected to continue to expand. During 1999-2001, one hundred and forty-two cases of neuroinvasive WN viral disease of the central nervous system (including 18 fatalities), and seven cases of uncomplicated WN fever were reported in the USA. Most human WN viral infections are subclinical but clinical infections can range in severity from uncomplicated WN fever to fatal meningoencephalitis; the incidence of severe neuroinvasive disease and death increase with age. Serology remains the mainstay of laboratory diagnosis. No WN virus-specific treatment or vaccine is available. Prevention depends on organized, sustained vector mosquito control, and public education.
KW - clinical aspects
KW - disease prevention
KW - epidemiology
KW - geographical distribution
KW - human diseases
KW - laboratory diagnosis
KW - mosquito-borne diseases
KW - pathogenesis
KW - reviews
KW - viral diseases
KW - West Nile fever
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - clinical picture
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043026732&site=ehost-live&scope=site
UR - http://infection.thelancet.com
UR - email: GLCampbell@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pulmonary alterations associated with inhalation of occupational and environmental irritants.
AU - Castranova, V.
AU - Frazer, D. G.
AU - Manley, L. K.
AU - Dey, R. D.
T3 - Special section: occupational immunology
JO - International Immunopharmacology
JF - International Immunopharmacology
Y1 - 2002///
VL - 2
IS - 2/3
SP - 163
EP - 172
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 1567-5769
AD - Castranova, V.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mail Stop 2015, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023016372. Publication Type: Journal Article. Note: Special section: occupational immunology Language: English. Number of References: 56 ref. Registry Number: 624-83-9, 10028-15-6.
N2 - Many gases, vapours or particles found in occupational and/or environmental settings can act as irritants. In the present study, sensory irritants are characterized by the stimulation of neuropeptide release from sensory nerves in the nasal mucosa, whereas pulmonary irritants are characterized by recruitment of polymorphonuclear cells (PMNs) into bronchoalveolar airspaces, elevation of breathing frequency, and neuropeptide release from sensory fibres innervating the epithelium of the conducting airways. A review of data from our laboratory as well as results from others indicate that asphalt fume is a sensory irritant; toluene diisocyanate (TDI), methyl isocyanate and machining fluid act as both sensory and pulmonary irritants; whereas cotton dust, agricultural dusts, microbial products, leather conditioner and ozone exhibit responses characteristic of pulmonary irritants.
KW - bitumen
KW - dust
KW - fumes
KW - leather
KW - methyl isocyanate
KW - neuropeptides
KW - nose
KW - occupational hazards
KW - occupational health
KW - ozone
KW - respiratory system
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - agricultural dust
KW - asphalt
KW - toluene diisocyanate
KW - white cotton dust
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023016372&site=ehost-live&scope=site
UR - email: vic1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance of foodborne pathogens.
AU - White, D. G.
AU - Zhao, S. H.
AU - Simjee, S.
AU - Wagner, D. D.
AU - McDermott, P. F.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2002///
VL - 4
IS - 4
SP - 405
EP - 412
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 1286-4579
AD - White, D. G.: Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20023144783. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Veterinary Science; Veterinary Science
N2 - Emergence of bacterial antimicrobial resistance has become a serious problem worldwide. While much of the resistance observed in human medicine is attributed to inappropriate use in humans, there is increasing evidence that antimicrobial use in animals selects for resistant foodborne pathogens that may be transmitted to humans as food contaminants. Pathogens of interest include shiga toxin-producing Escherichia coli, Salmonella spp., Campylobacter spp., Listeria monocytogenes, and Yersinia spp.
KW - animal husbandry
KW - antibacterial agents
KW - bacterial diseases
KW - campylobacteriosis
KW - drug resistance
KW - food contamination
KW - food poisoning
KW - foodborne diseases
KW - gastroenteritis
KW - listeriosis
KW - livestock
KW - livestock farming
KW - salmonellosis
KW - Campylobacter
KW - Escherichia coli
KW - Listeria monocytogenes
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - food contaminants
KW - listerellosis
KW - livestock husbandry
KW - Salmonella infections
KW - Yersinia
KW - Agricultural Economics (EE110)
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023144783&site=ehost-live&scope=site
UR - email: dwhite@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biosensor technologies for detecting microbiological foodborne hazards.
AU - Hall, R. H.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2002///
VL - 4
IS - 4
SP - 425
EP - 432
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 1286-4579
AD - Hall, R. H.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, CFSAN/DVA/HFS 327, 200 C Street, SW Washington, DC 20204, USA.
N1 - Accession Number: 20023144785. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Agricultural Biotechnology
N2 - The convergence of molecular biology and miniaturized instrumentation has accelerated the development of biosensors with the specifications necessary to support pathogen reduction and quality programs in the food supply. Advances in optoelectronics, thin layer deposition, and microfabrication have provided many options for achieving microbiological detection goals. Some promising technologies are reviewed.
KW - biosensors
KW - biotechnology
KW - detection
KW - food safety
KW - foods
KW - methodology
KW - pathogens
KW - reviews
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
KW - Biosensors and Biological Nanotechnology (WW900) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023144785&site=ehost-live&scope=site
UR - email: rhh@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis unleashed: the impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis.
AU - Lawn, S. D.
AU - Butera, S. T.
AU - Shinnick, T. M.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2002///
VL - 4
IS - 6
SP - 635
EP - 646
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 1286-4579
AD - Lawn, S. D.: Tuberculosis/Mycobacteriology Branch, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023093970. Publication Type: Journal Article. Language: English. Number of References: 92 ref.
KW - granuloma
KW - HIV-1 infections
KW - human diseases
KW - immune response
KW - immunocompromised hosts
KW - opportunistic infections
KW - pathogenesis
KW - tuberculosis
KW - Human immunodeficiency virus 1
KW - man
KW - Mycobacterium tuberculosis
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023093970&site=ehost-live&scope=site
UR - email: stevelawn@yahoo.co.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Traumatic injuries in agriculture.
AU - Hard, D. L.
AU - Myers, J. R.
AU - Gerberich, S. G.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2002///
VL - 8
IS - 1
SP - 51
EP - 65
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Hard, D. L.: National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Mailstop 1811, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20023082441. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Agricultural Engineering; Public Health
N2 - The National Coalition for Agricultural Safety and Health (NCASH) in 1988 addressed issues in agriculture and noted "a sense of urgency ... arose from the recognition of the unabating epidemic of traumatic death and injury in American farming ..." This article provides an update to the NCASH conference on traumatic injuries in agriculture, a history on how the facts and figures were arrived at for the NCASH conference, and a current report on the status of traumatic injuries in agriculture in the USA. Fatal and nonfatal injuries are addressed along with national and regional surveillance systems. The Census of Fatal Occupational Injuries was used for reporting national agricultural production fatal injuries during the period 1992-98 (25.8 deaths per 100 000 workers), the Traumatic Injury Surveillance of Farmers 1993-95 was used to report nonfatal injuries occurring nationally (7.5/100 workers), and Regional Rural Injury Studies I and II were used to illustrate a regional approach along with in-depth, specific analyses. Fatality rates, which showed some decline in the 1980s, were fairly constant during the 1990s. Changes in nonfatal injury rates for this sector could not be assessed due to a lack of benchmark data. The main concerns identified in the 1989 NCASH report continue today: tractors are the leading cause of farm-related death due mostly to overturns; older farmers continue to be at the highest risk for farm fatalities; and traumatic injuries continue to be a major concern for youth living or working on US farms. Fatal and nonfatal traumatic injuries associated with agricultural production are a major public health problem that needs to be addressed through comprehensive approaches that include further delineation of the problem, particularly in children and older adults, and identification of specific risk factors through analytic efforts. Continued development of relevant surveillance systems and implementation of appropriate interventions are the primary challenges for the current decade.
KW - elderly
KW - farm workers
KW - farmers
KW - mortality
KW - occupational health
KW - reviews
KW - safety at work
KW - surveillance
KW - trauma
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - death rate
KW - elderly people
KW - occupational safety
KW - older adults
KW - senior citizens
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023082441&site=ehost-live&scope=site
UR - email: dlh6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dynamic performance of the mechanism of an automatically deployable ROPS.
AU - Etherton, J. R.
AU - Cutlip, R. G.
AU - Harris, J. R.
AU - Ronaghi, M.
AU - Means, K. H.
AU - Howard, S.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2002///
VL - 8
IS - 1
SP - 113
EP - 118
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Etherton, J. R.: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023082445. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Agricultural Engineering
N2 - The mechanism for an automatically deployable ROPS (AutoROPS) has been designed and tested. This mechanism is part of an innovative project to provide passive protection against rollover fatality to operators of new tractors used in both low-clearance and unrestricted-clearance tasks. The device is a spring-action, telescoping structure that releases on signal to pyrotechnic squibs that actuate release pins. Upper post motion begins when the release pins clear an internal piston. The structure extends until the piston impacts an elastomeric ring and latches at the top position. In lab tests the two-post structure consistently deployed in less than 0.3 second and latched securely. Static load tests of the telescoping structure and field upset tests of the fully functional AutoROPS have been successfully completed.
KW - automation
KW - equipment performance
KW - occupational hazards
KW - operators
KW - pins
KW - pistons
KW - safety at work
KW - tractors
KW - occupational safety
KW - Automation and Control (NN050)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023082445&site=ehost-live&scope=site
UR - email: jre1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Static load test performance of a telescoping structure for an automatically deployable ROPS.
AU - Etherton, J. R.
AU - Cutlip, R. G.
AU - Harris, J. R.
AU - Ronaghi, M.
AU - Means, K. H.
AU - Gillispie, A.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2002///
VL - 8
IS - 1
SP - 119
EP - 126
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Etherton, J. R.: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023082446. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Agricultural Engineering
N2 - The automatically deployable ROPS was developed as part of an innovative project to provide passive protection against overturn fatality to operators of new tractors used in both low-clearance and unrestricted-clearance tasks. The primary objective of this phase of the research was to build a telescoping structure that would prove that a ROPS can be built that will (1) reliably deploy on signal, (2) rise in a sufficiently short amount of time, (3) firmly latch in its deployed position, and (4) satisfy SAE J2194 testing requirements. The two-post structure had previously been found to meet deployment time criteria, and design analyses indicated that neither the slip-fit joint nor the latch pins would fail at test loading. Four directions of static loading were applied to the structure to satisfy SAE requirements. For the series of static loading tests, the raised structure was found to maintain a protective clearance zone after all loads were applied. The structure is overly stiff and should be redesigned to increase its ability to absorb ground-impact energy. Results of dynamic tests and field upset tests are reported in companion articles. The next phase of development is to optimize the structure so that it will plastically deform and absorb energy that would otherwise be transferred to the tractor chassis.
KW - automation
KW - equipment performance
KW - occupational hazards
KW - operators
KW - safety at work
KW - static loads
KW - static testing
KW - tractors
KW - occupational safety
KW - Automation and Control (NN050)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023082446&site=ehost-live&scope=site
UR - email: jre1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Coalitions: partnerships to promote agricultural health and safety.
AU - Palermo, T.
AU - Ehlers, J.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2002///
VL - 8
IS - 2
SP - 161
EP - 174
CY - St Joseph; USA
PB - American Society of Agricultural Engineers
SN - 1074-7583
AD - Palermo, T.: National Institute for Occupational Safety and Health, M/S H-2900, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20023102259. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health; Agricultural Engineering
N2 - A variety of partnerships and community-based organizations have been formed in the USA throughout the 1990s with the primary mission to promote agricultural safety and health. These groups are altruistic, creative, energetic, and provide critical perspectives for improving the safety and health of the agricultural workforce at the local, regional, and national levels. These coalitions have been created as a result of philanthropic support, public funding, grassroots interest, and personal experiences with agricultural injuries and fatalities. They are playing important roles in collaborating with researchers and in reaching the individual agricultural communities. They have been instrumental in conducting needs assessments and are critical to the development and implementation of successful surveillance programmes and interventions. Outreach and dissemination of research findings and other safety and health information to target audiences are strengths of these diverse coalitions. This article will focus on primarily community-based coalitions, providing an overview of the development, foci, membership activities, and contributions or impact of these groups during the 1990s and the challenges in maintaining and sustaining the coalitions. This information should be useful to those seeking to understand the activities of existing coalitions and identify potential partnerships for future activities.
KW - agricultural sector
KW - communities
KW - groups
KW - health promotion
KW - health protection
KW - membership
KW - organizations
KW - partnerships
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Health Economics (EE118) (New March 2000)
KW - Community Participation and Development (UU450) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023102259&site=ehost-live&scope=site
UR - email: tpalermo@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin A levels and immunity in humans.
AU - Jason, J.
AU - Archibald, L. K.
AU - Nwanyanwu, O. C.
AU - Sowell, A. L.
AU - Buchanan, I.
AU - Larned, J.
AU - Bell, M.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Jarvis, W. R.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2002///
VL - 9
IS - 3
SP - 616
EP - 621
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Jason, J.: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Environmental Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, U.S. Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023086873. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 130068-27-8, 68-26-8, 308079-78-9. Subject Subsets: Tropical Diseases; Human Nutrition
N2 - In animal studies, vitamin A deficiency induces a shift from type 2 (humoral) to type 1 (cellular) cytokines; there are no similar data for humans. Control of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis infections requires type 1 cytokine (cellular) immunity. These infections and vitamin A deficiency are highly prevalent in Africa. We therefore examined the interactions among serum vitamin A levels, immune parameters, HIV infection status, Mycobacterium bovis BCG vaccine scarring (as an indicator of a type 1 cytokine profile), and clinical findings for 70 hospitalized children in Malawi, Africa. Directly conjugated monoclonal antibodies and flow cytometry were used to assess cell-specific cytokine production by peripheral blood monocytes and lymphocyte subpopulations. The statistical techniques employed included nonparametric statistics and logistic regression analyses. Thirty percent of the participants had severe vitamin A deficiency (<10 µg/dl), 34% had moderate deficiency (10 to <20 µg/dl), and 36% had normal levels (≥20 µg/dl). Vitamin A levels were lower for HIV-positive than for HIV-negative children (median, 10 and 17 µg/dl, respectively). Vitamin A-deficient children (<20 µg/dl) were more likely than non-vitamin A-deficient children to have higher proportions of natural killer (NK) cells (median, 8.3 and 5.2%, respectively) and lower ratios of interleukin-10-producing monocytes to tumour necrosis factor alpha-producing monocytes after induction (median, 1.0 and 2.3, respectively). Vitamin A-deficient children were also more likely than non-vitamin A-deficient children to exhibit respiratory symptoms (47% vs. 12%) and visible BCG vaccine scars (83% vs. 48%), which are indicative of a type 1 response to vaccination. Vitamin A status did not vary with gender, age, incidence of malaria parasitaemia, blood culture positivity, or rates of mortality (6% of vitamin A-deficient children died vs. 20% of non-vitamin A-deficient children). Lower vitamin A levels were associated with a relative type 1 cytokine dominance and proportionately more NK cells, both of which may be somewhat beneficial to persons who are exposed to HIV, M. tuberculosis, or other type 1 pathogens.
KW - cell mediated immunity
KW - children
KW - cytokines
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunity
KW - interleukin 10
KW - monocytes
KW - natural killer cells
KW - retinol
KW - scars
KW - tuberculosis
KW - tumour necrosis factor
KW - vitamin A deficiency
KW - Malawi
KW - man
KW - Mycobacterium bovis
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - axerophthol
KW - bacterium
KW - cachectin
KW - cachexin
KW - cellular immunity
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - hypovitaminosis A
KW - Nyasaland
KW - tumor necrosis factor
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023086873&site=ehost-live&scope=site
UR - email: JMJ1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spontaneous cytokine production and its effect on induced production.
AU - Walker, D.
AU - Jason, J.
AU - Wallace, K.
AU - Slaughter, J.
AU - Whatley, V.
AU - Han, A.
AU - Nwanyanwu, O. C.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Archibald, L.
AU - Jarvis, W. R.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2002///
VL - 9
IS - 5
SP - 1049
EP - 1056
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Walker, D.: Mailstop A-25, HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research (DASTLR), National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Rd., N.E., Atlanta, GA 30333, USA.
N1 - Accession Number: 20023145842. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9008-11-1, 130068-27-8, 102524-44-7, 85898-30-2, 207137-56-2, 308079-78-9, 142298-00-8. Subject Subsets: Public Health
N2 - Cytokines regulate cellular immune activity and are produced by a variety of cells, especially lymphocytes, monocytes, and macrophages. Multiparameter flow cytometry is often used to examine cell-specific cytokine production after in vitro phorbol 12-myristate 13-acetate and ionomycin induction, with brefeldin A or other agents added to inhibit protein secretion. Spontaneous ex vivo production reportedly rarely occurs. We examined the spontaneous production of interleukin 2 (IL-2), IL-4, IL-6, IL-8, IL-10, tumour necrosis factor alpha (TNF-α), and gamma interferon (IFN-γ) by peripheral-blood B lymphocytes, T cells, CD8- T cells, CD8+ T cells, CD3- CD16/56+ lymphocytes (natural killer (NK) cells), CD3+ CD16/56+ lymphocytes (natural T (NT) cells), and/or monocytes of 316 acutely ill hospitalized persons and 62 healthy adults in Malawi, Africa. We also evaluated the relationship between spontaneous and induced cytokine production. In patients, spontaneous TNF-α production occurred most frequently, followed in descending order by IFN-γ, IL-8, IL-4, IL-10, IL-6, and IL-2. Various cells of 60 patients spontaneously produced TNF-α; for 12 of these patients, TNF-α was the only cytokine produced spontaneously. Spontaneous cytokine production was most frequent in the immunoregulatory cells, NK and NT. For IL-2, IL-4, IL-6, IL-8, and IL-10, spontaneous cytokine production was associated with greater induced production. For TNF-α and IFN-γ, the relationships varied by cell type. For healthy adults, IL-6 was the cytokine most often produced spontaneously. Spontaneous cytokine production was not unusual in these acutely ill and healthy persons living in an area where human immunodeficiency virus, mycobacterial, malaria, and assorted parasitic infections are endemic. In such populations, spontaneous, as well as induced, cell-specific cytokine production should be measured and evaluated in relation to various disease states.
KW - B lymphocytes
KW - CD8+ lymphocytes
KW - cytokines
KW - immune response
KW - immunity
KW - interferon
KW - interleukin 10
KW - interleukin 2
KW - interleukin 4
KW - interleukin 6
KW - interleukin 8
KW - interleukins
KW - natural killer cells
KW - T lymphocytes
KW - tumour necrosis factor
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - B cells
KW - cachectin
KW - cachexin
KW - CD3+ lymphocytes
KW - CD8+ cells
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - T8 lymphocytes
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023145842&site=ehost-live&scope=site
UR - email: ziq4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century.
AU - Gubler, D. J.
JO - Trends in Microbiology
JF - Trends in Microbiology
Y1 - 2002///
VL - 10
IS - 2
SP - 100
EP - 103
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0966-842X
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20033098141. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health; Tropical Diseases; Medical & Veterinary Entomology
N2 - This paper examines the social, economic and public health impact of resurging epidemics of dengue fever/dengue haemorrhagic fever (DF/DHF) in affected Asian and American tropical countries. Since DF/DHF epidemics have a significant impact comparable to some of the most visible infectious diseases, disease control programmes should focus on the control of the principal mosquito vector, Aedes aegypti.
KW - dengue
KW - dengue haemorrhagic fever
KW - disease vectors
KW - economic impact
KW - epidemics
KW - human diseases
KW - mosquito-borne diseases
KW - public health
KW - social impact
KW - Aedes aegypti
KW - Culicidae
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - dengue hemorrhagic fever
KW - mosquitoes
KW - Health Economics (EE118) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033098141&site=ehost-live&scope=site
UR - email: dgubler@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pyrrolizidine alkaloids - tumorigenic components in Chinese herbal medicines and dietary supplements.
AU - Fu, P. P.
AU - Yang, Y. C.
AU - Xia, Q. S.
AU - Chou, M. W.
AU - Cui, Y. Y.
AU - Lin, G.
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
Y1 - 2002///
VL - 10
IS - 4
SP - 198
EP - 211
CY - Taipei; Taiwan
PB - National Laboratories of Foods and Drugs Department of Health, Executive Yuan
SN - 1021-9498
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033025325. Publication Type: Journal Article. Language: English. Language of Summary: Chinese. Number of References: 122 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science
N2 - Traditional Chinese medicine (TCM) has long been used for treating illness in China and other Asian countries, and recently used by the Western countries in several different ways, either for new drug development, or as functional foods and dietary supplements. However, quality assurance and health adverse effects of the herbal plants have not been well studied. Pyrrolizidine alkaloids, a class of hepatotoxic and tumourigenic compounds, have been detected in herbal plants and dietary supplements. In this review, the sources of the pyrrolizidine alkaloid-containing Chinese herbal plants in China and the toxicity, genotoxicity, and tumourigenicity of these compounds are discussed. The metabolic pathways, particularly the activation pathways leading to genotoxicity, are discussed. Recent mechanistic studies indicate that pyrrolizidine alkaloids induce tumours via a genotoxic mechanism mediated by 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adduct formation. This mechanism may be general to most carcinogenic pyrrolizidine alkaloids. Perspectives are included for suggestion of directions of future research.
KW - biochemical pathways
KW - carcinogens
KW - diets
KW - drug development
KW - food supplements
KW - functional foods
KW - genotoxicity
KW - herbal drugs
KW - pyrrolizidine alkaloids
KW - reviews
KW - toxicity
KW - herbal medicines
KW - metabolic pathways
KW - tumourigenicity
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033025325&site=ehost-live&scope=site
UR - email: pfu@nctr.fda.gov\linge@cuhk.edu.hk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The food safety perspective of antibiotic resistance.
AU - McDermott, P. F.
AU - Zhao, S.
AU - Wagner, D. D.
AU - Simjee, S.
AU - Walker, R. D.
AU - White, D. G.
A2 - Mackie, R. I.
A2 - White, B.
A2 - Hollis, G. R.
JO - Animal Biotechnology
JF - Animal Biotechnology
Y1 - 2002///
VL - 13
IS - 1
SP - 71
EP - 84
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 1049-5398
AD - McDermott, P. F.: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20023135783. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - Bacterial antimicrobial resistance in both the medical and agricultural fields has become a serious problem worldwide. Antibiotic resistant strains of bacteria are an increasing threat to animal and human health, with resistance mechanisms having been identified and described for all known antimicrobials currently available for clinical use. There is currently increased public and scientific interest regarding the administration of therapeutic and sub-therapeutic antimicrobials to animals, due primarily to the emergence and dissemination of multiple antibiotic resistant zoonotic bacterial pathogens. This issue has been the subject of heated debates for many years, however, there is still no complete consensus on the significance of antimicrobial use in animals, or resistance in bacterial isolates from animals, on the development and dissemination of antibiotic resistance among human bacterial pathogens. In fact, the debate regarding antimicrobial use in animals and subsequent human health implications has been going on for over 30 years, beginning with the release of the Swann report in the United Kingdom. The latest report released by the National Research Council (1998) confirmed that there were substantial information gaps that contribute to the difficulty of assessing potential detrimental effects of antimicrobials in food animals on human health. Regardless of the controversy, bacterial pathogens of animal and human origin are becoming increasingly resistant to most frontline antimicrobials, including expanded-spectrum cephalosporins, aminoglycosides, and even fluoroquinolones. The lion's share of these antimicrobial resistant phenotypes is gained from extra-chromosomal genes that may impart resistance to an entire antimicrobial class. In recent years, a number of these resistance genes have been associated with large, transferable, extra-chromosomal DNA elements, called plasmids, on which may be other DNA mobile elements, such as transposons and integrons. These DNA mobile elements have been shown to transmit genetic determinants for several different antimicrobial resistance mechanisms and may account for the rapid dissemination of resistance genes among different bacteria. The increasing incidence of antimicrobial resistant bacterial pathogens has severe implications for the future treatment and prevention of infectious diseases in both animals and humans. Although much scientific information is available on this subject, many aspects of the development of antimicrobial resistance still remain uncertain. The emergence and dissemination of bacterial antimicrobial resistance is the result of numerous complex interactions among antimicrobials, microorganisms, and the surrounding environments. Although research has linked the use of antibiotics in agriculture to the emergence of antibiotic-resistant foodborne pathogens, debate still continues whether this role is significant enough to merit further regulation or restriction.
KW - aminoglycoside antibiotics
KW - antibiotics
KW - cephalosporins
KW - chromosomes
KW - DNA
KW - domestic animals
KW - drug resistance
KW - food safety
KW - genes
KW - genetics
KW - phenotypes
KW - transposable elements
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - deoxyribonucleic acid
KW - DNA insertion elements
KW - fluoroquinolone
KW - insertion elements
KW - insertion sequences
KW - integrons
KW - mobile genetic elements
KW - mobile sequences
KW - transposons
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023135783&site=ehost-live&scope=site
UR - email: dwhite@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance and investigation of foodborne diseases; roles for public health in meeting objectives for food safety.
AU - Tauxe, R. V.
JO - Food Control
JF - Food Control
Y1 - 2002///
VL - 13
IS - 6/7
SP - 363
EP - 369
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0956-7135
AD - Tauxe, R. V.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20023136859. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Each year, an estimated 76 000 000 persons experience a foodborne infection in the United States. Preventing foodborne infections requires sustained efforts along the entire chain of production. Public health surveillance drives a number of disease prevention programmes, including tuberculosis control, polio eradication, and foodborne disease prevention. The Center for Disease Control (CDC) has launched several new approaches to food-borne disease surveillance, including FoodNet, PulseNet, and the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS). The capacity of public health surveillance in the United States to detect and investigate dispersed food-borne disease outbreaks has been improving dramatically in recent years. Investigation of such outbreaks can yield important insights in how to improve prevention strategies. Many food-borne diseases are preventable, though prevention will require a number of control efforts along the chain from production to consumption. Although progress has been made to date as a result of recent improvements in food safety, further prevention efforts are required in the United States if we are to reach the public health objectives set for 2010.
KW - disease control
KW - disease prevention
KW - disease surveys
KW - epidemiology
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - public health
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease surveillance
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
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UR - email: rvt1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exploring similarity between peer educators and their contacts and AIDS-protective behaviours in reproductive health programmes for adolescents and young adults in Ghana.
AU - Wolf, R. C.
AU - Bond, K. C.
A2 - Hedge, B.
A2 - Catalan, J.
A2 - Fishbein, M.
A2 - Boom, F. van den
A2 - Sherr, L.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002///
VL - 14
IS - 3
SP - 361
EP - 373
CY - Basingstoke; UK
PB - Carfax Publishing, Taylor & Francis Ltd
SN - 0954-0121
AD - Wolf, R. C.: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20023090421. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 30 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - This analysis explores the similarity between peer educators and their contacts. To examine interpersonal communication in the context of peer education, this study tested a new approach using multiple semi-structured interviews and network analysis to collect data from 106 peer educators and 526 of their contacts. These evaluation activities were conducted at three sites in Ghana during April 1998, in peri-urban and rural locations, and in in-school and out-of-school targeted settings. It was found that in their peer counselling and peer promotion activities peer educators tend to reach people who are like themselves (53% within 2 years of age, 59% same sex, 70% same ethnicity, and 65% same school status) however, this trend is not uniform among all youth and varies by demographic characteristics and their cultural environment. By examining the social networks of peer educators, it is possible to gain a better understanding of the process of peer education counselling in the context in which it occurs. The study also shows that controlling for other factors, contacts of peer educators who are highly similar regarding age, sex, ethnicity, and school status, are 1.74 times more likely (95% CI: 1.18, 2.56) to have done something to protect themselves from AIDS in the past three months. The results have relevance for programme managers and planners, researchers, and international agencies serving youth.
KW - acquired immune deficiency syndrome
KW - adolescents
KW - age
KW - behaviour
KW - children
KW - communication
KW - counselling
KW - ethnicity
KW - health education
KW - health programs
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - network analysis
KW - Ghana
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - AIDS
KW - behavior
KW - counseling
KW - ethnic differences
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - teenagers
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023090421&site=ehost-live&scope=site
UR - email: cwolf@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Associations between HIV-positive individuals' receipt of ancillary services and medical care receipt and retention.
AU - Ashman, J. J.
AU - Conviser, R.
AU - Pounds, M. B.
T3 - Evaluating the contribution of ancillary services in improving access to primary care in the United States under the Ryan White CARE Act.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002///
VL - 14
SP - S109
EP - S118
CY - Basingstoke; UK
PB - Carfax Publishing, Taylor & Francis Ltd
SN - 0954-0121
AD - Ashman, J. J.: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Rm. 7-90, Rockville, MD 20857, USA.
N1 - Accession Number: 20023126111. Publication Type: Journal Article. Note: Evaluating the contribution of ancillary services in improving access to primary care in the United States under the Ryan White CARE Act. Language: English. Number of References: 2 ref. Subject Subsets: Public Health
N2 - This study examines associations between HIV-positive individuals' receipt of ancillary services and their receipt of and retention in primary medical care. Ancillary care services examined include case management, mental health and substance abuse treatment/counselling, advocacy, respite and buddy/companion services, as well as food, housing, emergency financial assistance, and transportation. The selection criterion used was the receipt of care during January-June 1997 at selected facilities receiving funding under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act, a federally funded safety net programme in the USA. The receipt of each ancillary service was associated with the receipt of any primary medical care from a safety net provider. All ancillary services were more strongly associated with primary care receipt than with retention in care or the mean number of primary care visits per year. Mental health and substance abuse treatment/counselling, client advocacy, respite care and buddy/companion services all had significant associations with all primary medical care measures. This is the first time in one study that the primary medical and ancillary services received by all clients at safety net-funded providers from multiple cities and states have been examined. All types of safety net providers, from the largest medical centre to the smallest community-based organization, are represented in this study. The patterns seen here are similar to the findings from the other, geographically more restricted, studies reported on in this volume.
KW - counselling
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - mental health
KW - primary health care
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - counseling
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023126111&site=ehost-live&scope=site
UR - email: jashman@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The role of ancillary services in client-centred systems of care.
AU - Conviser, R.
AU - Pounds, M. B.
T3 - Evaluating the contribution of ancillary services in improving access to primary care in the United States under the Ryan White CARE Act.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002///
VL - 14
SP - S119
EP - S131
CY - Basingstoke; UK
PB - Carfax Publishing, Taylor & Francis Ltd
SN - 0954-0121
AD - Conviser, R.: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 7C-07, Rockville, MD 20857, USA.
N1 - Accession Number: 20023126112. Publication Type: Journal Article. Note: Evaluating the contribution of ancillary services in improving access to primary care in the United States under the Ryan White CARE Act. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - The studies in this issue reflect the operation of the Ryan White CARE Act's holistic model of health and support services for people living with HIV in the USA. Ancillary services available through the CARE Act are responsive to predisposing factors, enabling factors, and system characteristics that pose barriers to clients' receipt of primary medical care. That nearly all of the studies use cross-sectional rather than longitudinal data makes it difficult to draw causal inferences. Taken as a whole, however, the studies suggest that receipt of ancillary services such as case management, mental health and substance abuse treatment, transportation, and housing assistance is associated with primary care entry and retention among CARE Act clients. The studies and the literature out of which they arise suggest that there is a need to refine further our understanding of care systems so that we can refine the care systems themselves. Among the concepts proposed for the study of care systems are comprehensiveness, capacity, coordination, integration, cultural competence, and client-centredness.
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - mental health
KW - primary health care
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023126112&site=ehost-live&scope=site
UR - email: Rconviser@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro cultivation of Cryptosporidium species.
AU - Arrowood, M. J.
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
Y1 - 2002///
VL - 15
IS - 3
SP - 390
EP - 400
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0893-8512
AD - Arrowood, M. J.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023128484. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Public Health; Protozoology
N2 - Some important aspects regarding in vitro culture of Cryptosporidium sp. including cryopreservation and oocysts sources (faecal collection and processing for oocyst recovery) are briefly discussed. Oocyst and sporozoite preparation for inoculation onto cell cultures, oocyst labelling to differentiate inocula from developing parasites, host cell preparation and recommended parasite inoculum densities, parasite enumeration in culture, and immunofluorescence identification of parasites in cell cultures are discussed.
KW - cell cultures
KW - cryopreservation
KW - cryptosporidiosis
KW - faeces
KW - faeces collection
KW - growth
KW - human diseases
KW - in vitro culture
KW - labelling
KW - oocysts
KW - reviews
KW - sporozoites
KW - Cryptosporidium
KW - man
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - feces
KW - feces collection
KW - labeling
KW - labels
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023128484&site=ehost-live&scope=site
UR - email: marrowood@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multi-element analysis of food by microwave digestion and inductively coupled plasma-atomic emission spectrometry.
AU - Dolan, S. P.
AU - Capar, S. G.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2002///
VL - 15
IS - 5
SP - 593
EP - 615
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Dolan, S. P.: Elemental Research Branch (HFS-338), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20023169536. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 7439-89-6, 7439-92-1, 7439-95-4, 7439-96-5, 7439-98-7, 7440-02-0, 7723-14-0, 7440-09-7, 7782-49-2, 7440-23-5, 7440-24-6, 7440-28-0, 7440-62-2, 7440-66-6, 7429-90-5, 7440-38-2, 7440-39-3, 7440-42-8, 7440-43-9, 7440-70-2, 7440-47-3, 7440-48-4, 7440-50-8. Subject Subsets: Human Nutrition
N2 - A microwave digestion procedure for multi-elemental analysis of food was developed using one programme to digest a variety of food matrices at the same time. A single program was enabled by an analytical portion mass based on the food's energy content calculated from macronutrient data (fat, protein and carbohydrate). The procedure allows a maximum mass to be analysed for each food matrix without adjustment of the microwave digestion program to compensate for the variable reactivity of food matrices. Inductively coupled plasma-atomic emission spectrometry with ultrasonic nebulization was used to determine aluminium, arsenic, boron, barium, calcium, cadmium, cobalt, chromium, copper, iron, potassium, magnesium, manganese, molybdenum, sodium, nickel, phosphorus, lead, selenium, strontium, thallium, vanadium, and zinc. Method validation was performed on seven certified reference materials and 20 foods. Element fortification recovery of foods was acceptable (88-113%) and a majority of available comparisons to reference materials indicated agreement except for aluminium, chromium, and selenium.
KW - aluminium
KW - analytical methods
KW - arsenic
KW - barium
KW - boron
KW - cadmium
KW - calcium
KW - chromium
KW - cobalt
KW - copper
KW - food analysis
KW - iron
KW - lead
KW - magnesium
KW - manganese
KW - methodology
KW - molybdenum
KW - nickel
KW - phosphorus
KW - potassium
KW - selenium
KW - sodium
KW - spectrometry
KW - strontium
KW - thallium
KW - vanadium
KW - zinc
KW - aluminum
KW - analytical techniques
KW - atomic emission spectrometry
KW - methods
KW - microwave digestion
KW - Mn
KW - Mo
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023169536&site=ehost-live&scope=site
UR - email: stephen.capar@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antioxidant balance and free radical generation in vitamin E-deficient mice after dermal exposure to cumene hydroperoxide.
AU - Shvedova, A. A.
AU - Kisin, E. R.
AU - Murray, A. R.
AU - Kommineni, C.
AU - Castranova, V.
AU - Mason, R. P.
AU - Kadiiska, M. B.
AU - Gunther, M. R.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2002///
VL - 15
IS - 11
SP - 1451
EP - 1459
CY - Washington; USA
PB - American Chemical Society
SN - 0893-228X
AD - Shvedova, A. A.: Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, m/s 2015, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20033008971. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 70-18-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - Organic peroxides are widely used in the chemical industry as initiators of oxidation for the production of polymers and fiber-reinforced plastics, in the manufacture of polyester resin coatings, and pharmaceuticals. Free radical production is considered to be one of the key factors contributing to skin tumor promotion by organic peroxides. In vitro experiments have demonstrated metal-catalyzed formation of alkoxyl, alkyl, and aryl radicals in keratinocytes incubated with cumene hydroperoxide. The present study investigated in vivo free radical generation in lipid extracts of mouse skin exposed to cumene hydroperoxide. The electron spin resonance (ESR) spin-trapping technique was used to detect the formation of α-phenyl-N-tert-butylnitrone (PBN) radical adducts, following intradermal injection of 180 mg/kg PBN. It was found that 30 min after topical exposure, cumene hydroperoxide (12 mmol/kg) induced free radical generation in the skin of female Balb/c mice kept for 10 weeks on vitamin E-deficient diets. In contrast, hardly discernible radical adducts were detected when cumene hydroperoxide was applied to the skin of mice fed a vitamin E-sufficient diet. Importantly, total antioxidant reserve and levels of GSH, ascorbate, and vitamin E decreased 34%, 46.5%. 27%, and 98%, respectively, after mice were kept for 10 weeks on vitamin E-deficient diet. PBN adducts detected by ESR in vitamin E-deficient mice provide direct evidence for in vivo free radical generation in the skin after exposure to cumene hydroperoxide.
KW - animal models
KW - antioxidants
KW - free radicals
KW - glutathione
KW - peroxides
KW - skin
KW - vitamin deficiencies
KW - vitamin E
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cumene hydroperoxide
KW - dermis
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033008971&site=ehost-live&scope=site
UR - email: ats1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection.
AU - Pisell, T. L.
AU - Hoffman, I. F.
AU - Jere, C. S.
AU - Ballard, S. B.
AU - Molyneux, M. E.
AU - Butera, S. T.
AU - Lawn, S. D.
JO - AIDS
JF - AIDS
Y1 - 2002///
VL - 16
IS - 11
SP - 1503
EP - 1509
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Pisell, T. L.: HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20023109340. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Objectives: To determine the impact of P. falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons in Malawi, and to relate this to changes in systemic immune activation. Methods: Plasma samples were obtained from HIV-1-infected individuals (n=10) at diagnosis of acute malaria, 4 weeks after parasite clearance and from HIV-infected aparasitaemic controls (n=10). Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using ELISA. Results: Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. Conclusions: Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation.
KW - antimalarials
KW - concurrent infections
KW - cytokines
KW - disease course
KW - drug therapy
KW - HIV-1 infections
KW - immune response
KW - immunocompromised hosts
KW - lymphocytes
KW - macrophages
KW - malaria
KW - viral replication
KW - Malawi
KW - Human immunodeficiency virus 1
KW - Plasmodium falciparum
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - chemotherapy
KW - disease progression
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - Nyasaland
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023109340&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Update on animal dietary supplements.
AU - Grassie, L. A.
JO - FDA Veterinarian
JF - FDA Veterinarian
Y1 - 2002///
VL - 17
IS - 3
SP - 3
EP - 6
CY - Rockville; USA
PB - Food and Drug Administration
SN - 1057-6223
AD - Grassie, L. A.: Center for Veterinary Medicine (CVM), FDA Veterinarian (HFV-12), 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20023082592. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition
KW - feed additives
KW - feed supplements
KW - minerals
KW - safety
KW - vitamins
KW - Feed Additives (RR130)
KW - Feed Composition and Quality (RR300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023082592&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Peripheral blood cell-specific cytokines in persons with untreated HIV infection in Malawi, Africa.
AU - Chatt, J. A.
AU - Jason, J.
AU - Nwanyanwu, O. C.
AU - Archibald, L. K.
AU - Parekh, B.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Jarvis, W. R.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 2002///
VL - 18
IS - 18
SP - 1367
EP - 1377
CY - Larchmont; USA
PB - Mary Ann Liebert, Inc.
SN - 0889-2229
AD - Chatt, J. A.: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033137840. Publication Type: Journal Article. Language: English. Registry Number: 102524-44-7, 85898-30-2. Subject Subsets: Tropical Diseases; Protozoology
N2 - Human immunodeficiency virus (HIV) infection is the primary cause of morbidity and mortality in Malawi, Africa, because of its many effects on the immune system. Immune cells communicate through cytokines; therefore, we examined the relationships between HIV serostatus and cell-specific cytokine production for 40 asymptomatic, employed adults and 312 acutely ill, hospitalized patients in Malawi. We also measured the plasma HIV-1 RNA levels of 13 asymptomatic persons and 83 patients found to be HIV+. We incubated peripheral whole blood with brefeldin-A±phorbol 12-myristate 13-acetate and ionomycin and then permeabilized, fixed, fluorescently stained, and examined the mononuclear cells with four-colour, six-parameter flow cytometry. The percentage of lymphocytes expressing CD4 did not differ significantly between the HIV+ and HIV- healthy adults (medians, 35.2 vs. 40.8%, respectively), but a wide array of cytokine parameters were lower in the HIV+ than in the HIV- asymptomatic persons, for example, median percentages of T cells producing induced interleukin 2 (IL-2) (8.7 vs. 16.5%, respectively) and spontaneously producing IL-6 (0.7 vs. 11.0%, respectively). Also, four T cell parameters reflecting type 2-to-type 1 cytokine balances (T2/T1) were higher in the HIV+, versus HIV-, asymptomatic persons. Unlike the healthy adults, for patients with mycobacteraemia/fungaemia or malaria, the HIV+ patients had higher median percentages of T cells and CD8+ T cells producing induced interferon γ than did the HIV- patients. For both asymptomatic and acutely ill persons, HIV-1 plasma levels were positively correlated with T2/T1 parameters. Cell-specific cytokine effects of HIV infection may precede measurable effects on CD4 expression. Cytokine therapies, even beyond periodic administration of IL-2, may improve the responses of HIV-infected persons to both HIV and coinfections.
KW - HIV-1 infections
KW - human diseases
KW - immunity
KW - interleukin 2
KW - malaria
KW - T lymphocytes
KW - Malawi
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - human immunodeficiency virus type 1
KW - Nyasaland
KW - T cells
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033137840&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US Food and Drug Administration's Total Diet Study: intake of nutritional and toxic elements, 1991-96.
AU - Egan, S. K.
AU - Tao, S. S. H.
AU - Pennington, J. A. T.
AU - Bolger, P. M.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2002///
VL - 19
IS - 2
SP - 103
EP - 125
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Egan, S. K.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St SW, Washington, DC 20204, USA.
N1 - Accession Number: 20023142090. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health; Human Nutrition
N2 - The Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) annually since 1961. The TDS is designed to monitor the US food supply for levels of toxic chemical contaminants (pesticide residues, industrial chemicals and toxic elements) and nutritional elements. Foods are generally collected four times a year, once from each of four regions of the country. The foods are prepared table-ready before being analysed. From the results of the TDS, dietary intakes of these analytes are estimated for selected age-sex groups in the US population. This paper reports on the dietary intake of 10 nutritional and four toxic elements based on measurements made in foods collected in the TDS between 1991 and late 1996. Average daily intakes were estimated for 14 age-sex groups in the US population, as well as the contribution of specific food groups to total intakes. For most nutritional elements, teenage boys and adult males had the highest daily intakes. Intakes by infants were below the intake references for seven of 10 nutritional elements, and young girls and women had inadequate intakes of at least half the nutritional elements. Intakes by children between 2 and 10 years of age, teenage boys, and adult males met or exceeded the reference intakes for the majority of nutritional elements. Intakes by all population groups were well below the reference intakes for all toxic elements.
KW - food contamination
KW - industrial wastes
KW - pesticide residues
KW - surveys
KW - toxicity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023142090&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occurrence of aflatoxins and fumonisins in Incaparina from Guatemala.
AU - Trucksess, M. W.
AU - Dombrink-Kurtzman, M. A.
AU - Tournas, V. H.
AU - White, K. D.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2002///
VL - 19
IS - 7
SP - 671
EP - 675
CY - London; UK
PB - Taylor & Francis Ltd
SN - 0265-203X
AD - Trucksess, M. W.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20023142965. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology; World Agriculture, Economics & Rural Sociology; Maize; Tropical Diseases; Rural Development
N2 - The occurrence of aflatoxins and fumonisins in Incaparina was investigated. Incaparina is a mixture of corn (maize) and cottonseed flour with added vitamins, minerals and a preservative. It has been marketed as a high-protein food supplement, particularly for children on protein-deficient diets. According to estimates, 80% of Guatemalan children in their first year are given Incaparina to provide an adequate diet. Eight samples of Incaparina manufactured in Guatemala were collected. Five were from three different geographical locations in the USA (collected in 1998 in Chicago, Illinois and Los Angeles and San Francisco, both in California) and three were from Guatemala (purchased in 2000). Seven were examined for fungal contamination and analysed for aflatoxins and fumonisins. Aspergillus flavus was the predominant fungus in all samples purchased in the USA and in one sample purchased from Guatemala, whereas Fusarium verticillioides was present in only two samples (one from the USA and one from Guatemala). All samples contained aflatoxins, ranging from 3 to 214 ng g-1 and <2 to 32 ng g-1 for aflatoxin B1 and aflatoxin B2, respectively; and one sample contained aflatoxin G1 (7 ng g-1). Total aflatoxins present ranged from 3 to 244 ng g-1. All samples contained fumonisins, ranging from 0.2 to 1.7 µg g-1, <0.1 to 0.6 µg g-1, and <0.1 to 0.2 µg g-1 for fumonisins B1, fumonisin B2, and fumonisin B3, respectively. Total fumonisins present ranged from 0.2 to 2.2 µg g-1. The identity of aflatoxin B1 was confirmed using both the chemical derivatization method and liquid chromatographic (LC)/mass spectrometric (MS) analysis. Appropriate regulatory action was recommended for the import of Incaparina and has been in effect since 22 December 1998.
KW - aflatoxins
KW - consumer protection
KW - corn flour
KW - cottonseed
KW - cottonseed products
KW - food contamination
KW - food policy
KW - food supplements
KW - fumonisins
KW - imports
KW - maize
KW - mycotoxins
KW - California
KW - Guatemala
KW - Illinois
KW - USA
KW - Aspergillus flavus
KW - Fusarium
KW - Gibberella fujikuroi
KW - Hypocreaceae
KW - Zea mays
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Gibberella
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Fusarium
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - CACM
KW - Central America
KW - Developing Countries
KW - Latin America
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - consumer advocacy
KW - corn
KW - cornflour
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Fusarium verticillioides
KW - Gibberella moniliformis
KW - Hyphomycetes
KW - maize flour
KW - United States of America
KW - Food Economics (EE116) (New March 2000)
KW - Policy and Planning (EE120)
KW - Consumer Economics (EE720)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023142965&site=ehost-live&scope=site
UR - email: mtruckse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dual role of organosulfur compounds in foods: a review.
AU - Sahu, S. C.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2002///
VL - 20
IS - 1
SP - 61
EP - 76
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 1059-0501
AD - Sahu, S. C.: Division of In Vitro and Biochemical Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20023095127. Publication Type: Journal Article. Language: English. Number of References: 100 ref. Registry Number: 7704-34-9. Subject Subsets: Human Nutrition
N2 - The potential toxicity and adverse health effects of organic sulfur compounds present in natural foods relative to their benefits are reviewed. The free radical mechanisms of toxicity of organic sulfur compounds, and the role of organic sulfur compounds as sources of oxygen radicals, as prooxidants, antioxidants, antimutagens and anticarcinogens are discussed. Their beneficial effects on cardiovascular diseases are examined.
KW - anticarcinogenic properties
KW - antimutagenic properties
KW - antioxidant properties
KW - antioxidants
KW - cardiovascular diseases
KW - foods
KW - free radicals
KW - organic sulfur compounds
KW - oxidants
KW - reviews
KW - sulfur
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-carcinogenic properties
KW - anti-mutagenic properties
KW - anti-oxidant properties
KW - elemental sulphur
KW - organic sulphur compounds
KW - organosulphur compounds
KW - oxidizing agents
KW - sulphur
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023095127&site=ehost-live&scope=site
UR - email: Saura.Sahu@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aluminum salts in vaccines - US perspective.
AU - Baylor, N. W.
AU - Egan, W.
AU - Richman, P.
A2 - Poland, G. A.
JO - Vaccine
JF - Vaccine
Y1 - 2002///
VL - 20
SP - S18
EP - S23
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Baylor, N. W.: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, Maryland, USA.
N1 - Accession Number: 20023093716. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 19 ref. Registry Number: 7429-90-5. Subject Subsets: Public Health
KW - adjuvants
KW - adverse effects
KW - aluminium
KW - children
KW - diphtheria
KW - diphtheria pertussis tetanus vaccines
KW - diphtheria toxoid
KW - human diseases
KW - immunization
KW - pertussis
KW - tetanus
KW - tetanus toxoid
KW - vaccination
KW - vaccines
KW - USA
KW - Bordetella pertussis
KW - Clostridium tetani
KW - Corynebacterium diphtheriae
KW - man
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Corynebacterium
KW - Corynebacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - aluminum
KW - bacterium
KW - immune sensitization
KW - lockjaw
KW - United States of America
KW - whooping cough
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023093716&site=ehost-live&scope=site
UR - email: baylor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Medication errors reported to the vaccine adverse event reporting system (VAERS).
AU - Varricchio, F.
JO - Vaccine
JF - Vaccine
Y1 - 2002///
VL - 20
IS - 25/26
SP - 3049
EP - 3051
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Varricchio, F.: Office of Biostatistics and Epidemiology, Division of Epidemiology, Center for Biologics Evaluation and Review, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20023136006. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
KW - acellular vaccines
KW - adverse effects
KW - diphtheria
KW - diphtheria pertussis tetanus vaccines
KW - errors
KW - fever
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - pertussis
KW - tetanus
KW - vaccination
KW - vaccines
KW - varicella
KW - Bordetella pertussis
KW - Clostridium tetani
KW - Corynebacterium diphtheriae
KW - Human herpesvirus 3
KW - man
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Corynebacterium
KW - Corynebacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - adverse reactions
KW - bacterium
KW - chicken pox
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - lockjaw
KW - pyrexia
KW - varicella-zoster virus
KW - whooping cough
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023136006&site=ehost-live&scope=site
UR - email: varricchio@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - IL-1β gene polymorphisms influence hepatitis B vaccination.
AU - Yucesoy, B.
AU - Sleijffers, A.
AU - Kashon, M.
AU - Garssen, J.
AU - Gruijl, F. R. de
AU - Boland, G. J.
AU - Hattum, J. van
AU - Simeonova, P. P.
AU - Luster, M. I.
AU - Loveren, H. van
JO - Vaccine
JF - Vaccine
Y1 - 2002///
VL - 20
IS - 25/26
SP - 3193
EP - 3196
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Yucesoy, B.: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508, USA.
N1 - Accession Number: 20023136011. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1β (IL-1β) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1β expression. Ninety-two healthy individuals from the Netherlands who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule [date not given]. At selected times, antibody titres and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1β polymorphisms using a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titre and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1β (+3953) minor allelic variant.
KW - antibodies
KW - genetic polymorphism
KW - hepatitis B
KW - human diseases
KW - immune response
KW - immunization
KW - interleukin 1
KW - vaccination
KW - Netherlands
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023136011&site=ehost-live&scope=site
UR - email: mluster@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of diagnostic tests for influenza in a paediatric practice.
AU - Rodriguez, W. J.
AU - Schwartz, R. H.
AU - Thorne, M. M.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2002///
VL - 21
IS - 3
SP - 193
EP - 196
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Rodriguez, W. J.: Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Review Management, Office for Drug Evaluation IV, Rockville, Maryland, USA.
N1 - Accession Number: 20023052701. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
N2 - Introduction. Recent advances in the diagnosis and treatment of influenza virus infections include: (1) rapid bedside diagnosis methods with simple commercially available tests; and (2) Food and Drug Administration approval of treatment for children 1 year of age and older with neuraminidase inhibitor drugs. For proven benefit antivirals should be used within 2 days of onset of symptoms. Objectives. We conducted a performance improvement exercise comparing the sensitivity and specificity of 4 rapid tests for influenza viruses: (1) Flu OIA (Biostar); (2) Quickvue Influenza Test (Quidel); (3) Z Stat Flu (ZymeTx); and (4) Directigen Flu A (Becton Dickinson). Methods. During the 1999 to 2000 epidemic, symptomatic patients seen at the private practice of one of the authors provided specimens collected and processed according to the manufacturer's directions. Throat swabs only were used to collect the specimens for the Z Stat Flu Kit. Directigen was performed immediately, and the others were run in parallel within 12 to 24 h. Specimens were frozen first at -20°C for up to 3 days and shipped in transport medium to the Virology Research Laboratory of the Virginia State Health Department for culture where they were stored at -60°C until cultured. Some of the samples were processed by a commercial laboratory. Results. Specimens from 116 patients were available for influenza culture; for 88 of these culture was performed at the State Health Department Laboratory, and for 28 culture was performed at a local commercial medical laboratory. Influenza virus (A) was detected in 58 of 116 (50%) specimens, 10 (17%) of these only by direct fluorescent antigen samples. Viral culture-direct fluorescent antigen results were used as the standard. Of the 4 tests Biostar and Z Stat Flu required more technician time (by an average of 2-fold). The 4 tests had sensitivities ranging from 72 to 95%. Z Stat differed significantly in sensitivity from the other three (P=0.001). The specificities of Directigen, Quickvue, Flu OIA and Z Stat Flu were similar (76 to 86%). The positive predictive value of Directigen, Quickvue and FluOIA and Z Stat ranged from 80 to 86%. The negative predictive value of all 4 tests ranged from 75 to 94%. Z Stat Flu had a lower negative predictive value than the other 3 tests (75%; P=0.001). Conclusion. In this first head-to-head comparison of 4 rapid diagnostic tests for influenza, Directigen Flu A, Quickvue and Flu OIA appear equivalent in sensitivity, specificity, positive predictive value and negative predictive value. Z Stat Flu was not as sensitive or as efficient as the other 3 tests.
KW - children
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - influenza
KW - influenzavirus A
KW - man
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - flu
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023052701&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food labelling and claims as an educational tool: experience from Thailand.
AU - Kongchuntuk, H.
JO - Sciences des Aliments
JF - Sciences des Aliments
Y1 - 2002///
VL - 22
IS - 4
SP - 491
EP - 499
CY - Paris; France
PB - Lavoisier Publishing
SN - 0240-8813
AD - Kongchuntuk, H.: Food and Drug Administration, Ministry of Public Health, Nonthaburi 11000, Thailand.
N1 - Accession Number: 20023148732. Publication Type: Journal Article. Language: English. Subject Subsets: Rural Development; Tropical Diseases; World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - This article summarizes the development of food labelling regulations in Thailand. General labelling guidelines are briefly described. The food label features a unique logo on the food product, which contributes to consumer education. Nutrition policy and nutrition labelling, including mandatory nutrients and recommended dietary intakes, are discussed. The key principles of nutrition labelling and claims are outlined. Consumer education tools, such as manuals, videotapes, training sessions and communication aids, are recommended.
KW - consumer education
KW - food products
KW - foods
KW - guidelines
KW - labelling
KW - nutrients
KW - nutrition information
KW - nutrition knowledge
KW - nutrition policy
KW - recommended dietary allowances
KW - Thailand
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - labeling
KW - labels
KW - nutrition labelling
KW - RDA
KW - recommendations
KW - recommended dietary intakes
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Marketing and Distribution (EE700)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023148732&site=ehost-live&scope=site
UR - email: hatk@health.moph.go.th
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The water-soluble extract of chicory affects rat intestinal morphology similarly to other non-starch polysaccharides.
AU - Kim Meehye
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2002///
VL - 22
IS - 11
SP - 1299
EP - 1307
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0271-5317
AD - Kim Meehye: Department of Food Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20023189412. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 9004-34-6, 9005-80-5. Subject Subsets: Human Nutrition; Sugar Industry
N2 - Male Sprague Dawley rats were fed diets containing fibre-free (control), pectin (5%), chicory extract (1%, 5%), inulin (5%) and cellulose (5%) for 4 wk. Weight gains in NSP (non-starch polysaccharide)-fed groups were not significantly greater than those in control. However, rats fed 5% chicory extract and cellulose had significantly higher food intake than those fed the control diet (P<0.05). Relative weights of caecum were significantly higher in rats fed inulin diet than in other groups (P<0.05). All rats fed different NSP diets had significantly shorter transit time (oral to caecum) compared with control (P<0.05). Cellulose-fed rats excreted faeces most among other groups of rats (P<0.05). Morphological changes in jejunum, ileum and colon were examined. The addition of NSP resulted in significant increases in ileal villus heights compared to control (P<0.05). The results show that certain NSP may modify intestinal architecture and indicate that these structural changes may be correlated with altered functional characteristics.
KW - animal models
KW - caecum
KW - cellulose
KW - chicory
KW - colon
KW - diets
KW - ileum
KW - intestinal mucosa
KW - intestines
KW - inulin
KW - jejunum
KW - laboratory animals
KW - pectins
KW - polysaccharides
KW - Cichorium intybus
KW - rats
KW - Cichorium
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cecum
KW - complex carbohydrates
KW - intestine epithelium
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023189412&site=ehost-live&scope=site
UR - email: meehkim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multigenerational exposure to dietary nonylphenol has no severe effects on spatial learning in female rats.
AU - Flynn, K. M.
AU - Newbold, R. R.
AU - Ferguson, S. A.
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2002///
VL - 23
IS - 1
SP - 87
EP - 94
CY - Amsterdam; Netherlands
PB - Elsevier Inc.
SN - 0161-813X
AD - Flynn, K. M.: Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033038887. Publication Type: Journal Article. Language: English. Registry Number: 57-83-0. Subject Subsets: Soyabeans; Human Nutrition
N2 - Nonylphenol is a common intermediate in the production of many consumer compounds and reportedly acts as an estrogen mimic. Because estrogen affects the spatial learning and memory in rats, the effects of nonylphenol exposure on the performance of female rats in the Morris water maze were investigated. Here, Sprague-Dawley rats (F0) consumed soy-free diets containing 0, 25, 200 or 750 ppm nonylphenol (~0, 2, 16 or 60 mg/kg per day) beginning on postnatal day (PND) 42 and continuing for two generations (F1 and F2) with breeding occurring within treatments. Females to be behaviorally tested (n=7-8 per treatment per generation) were ovariectomized at adulthood and assessed for spatial learning and memory between PND 125-150 (young adult age). Each rat was tested for four consecutive days (three trials per day) in the Morris water maze with the platform in a fixed location. One week later, each subject was primed with estrogen and progesterone and assessed on a single day (three trials). The F1 rats continued on the same diets until PND 380-395 (middle aged) when they were re-tested as above (four consecutive days followed 1 week later with hormonal priming and a single test day). Latency to find the platform, path length and swim speed were averaged over the three trials per day and analyzed using repeated measures analyses of variance. There were no consistent effects of dietary nonylphenol exposure and no interactions of nonylphenol exposure on any measure of performance in either generation at the young age nor at the middle age in the F1 generation. When tested at the young adult age, however, hormone priming resulted in latencies and path lengths that were significantly shorter than in those exhibited during the unprimed test days, and there was no such effect when tested at middle age. Middle aged rats exhibited better performance than the same animals tested at a young age, likely as a result of familiarity and practice with the test paradigm. These data suggest that multigenerational dietary nonylphenol exposure does not cause gross alterations in Morris water maze performance in young adult or middle aged ovariectomized female rats.
KW - age
KW - animal models
KW - diets
KW - laboratory animals
KW - learning
KW - memory
KW - oestrogenic properties
KW - oestrogens
KW - phenols
KW - progesterone
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrogenic properties
KW - estrogens
KW - nonylphenol
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033038887&site=ehost-live&scope=site
UR - email: sferguson@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nosocomial transmission of hepatitis B virus infection among residents with diabetes in a skilled nursing facility.
AU - Khan, A. J.
AU - Cotter, S. M.
AU - Schulz, B.
AU - Hu, X. L.
AU - Rosenberg, J.
AU - Robertson, B. H.
AU - Fiore, A. E.
AU - Bell, B. P.
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2002///
VL - 23
IS - 6
SP - 313
EP - 318
CY - Thorofare; USA
PB - Slack Incorporated
SN - 0899-823X
AD - Khan, A. J.: Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20023149387. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition; Public Health
N2 - OBJECTIVE: To identify exposures associated with acute hepatitis B virus (HBV) infection among residents with diabetes in a skilled nursing facility. DESIGN: Residents from Unit 3 and other skilled nursing facility residents with diabetes were tested for serologic evidence of HBV infection. Two retrospective cohort studies were conducted. Potential routes of HBV transmission were evaluated by statistical comparison of attack rates. SETTING: A 269-bed skilled nursing facility. PARTICIPANTS: All skilled nursing facility residents with diabetes and skilled nursing facility residents who lived on the same unit as the index case (Unit 3) for some time during the case's incubation period. RESULTS: All 5 residents with acute HBV infection had diabetes and resided in Unit 3. The attack rate among the 12 patients with diabetes in Unit 3 was 42%, compared with 0% among 43 patients without diabetes (relative risk, 37.2; 95% confidence interval, 4.7 to ∞). Acutely infected patients with diabetes received more morning insulin doses (P=.05), and more insulin doses (P=.03) and finger sticks (P=.02) on Wednesdays than did noninfected patients with diabetes. Two chronically infected patients with diabetes in Unit 3 were positive for hepatitis B e antigen and regularly received daily insulin and finger sticks. Of the 4 acute and 3 chronically infected residents from whom HBV DNA was amplified, all were genotype F and had an identical 678-bp S region sequence. Although no component of the lancets or injection devices was shared among residents, opportunities for HBV contamination of diabetes care supplies were identified. CONCLUSIONS: Contamination of diabetes care supplies resulted in resident-to-resident transmission of HBV. In any setting in which diabetes care is performed, staff need to be educated regarding appropriate infection control practices.
KW - diabetes
KW - disease transmission
KW - DNA
KW - genotypes
KW - hepatitis B
KW - human diseases
KW - immunocompromised hosts
KW - molecular genetics
KW - nosocomial infections
KW - nucleotide sequences
KW - opportunistic infections
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - hospital infections
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023149387&site=ehost-live&scope=site
UR - http://www.slackinc.com/general/iche/stor0602/6khan.htm
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of lifelong dietary exposure to genistein or nonylphenol on amphetamine-stimulated striatal dopamine release in male and female rats.
AU - Ferguson, S. A.
AU - Flynn, K. M.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Gough, B. J.
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
Y1 - 2002///
VL - 24
IS - 1
SP - 37
EP - 45
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0892-0362
AD - Ferguson, S. A.: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023166851. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 51-61-6, 50-28-2, 446-72-0, 306-08-1. Subject Subsets: Human Nutrition; Soyabeans
N2 - Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylphenol, has estrogen-like effects. Here, Sprague-Dawley rats were continuously exposed to phytoestrogen-free diets containing 0, 100, or 500 ppm genistein (Experiment 1) or 0 or 200, or 750 ppm nonylphenol (Experiment 2) beginning at conception and continuing throughout. To eliminate estrous cycle influences on DA levels, females were ovariectomized at adulthood. As adults, striatal levels of DA and its metabolites [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] were measured in unanesthetized male and female rats via cerebral microdialysis before and for 200 min after an intraperitoneal injection of 2 mg/kg D-amphetamine. Although baseline 5-hydroxyindoleacetic acid (5-HIAA) levels indicated an isolated effect in genistein-treated females, there were no meaningful differences among treatment groups in baseline levels of DA, DOPAC, or HVA. However, dietary exposure to 500 ppm genistein significantly potentiated amphetamine-stimulated DA release in males and a similar trend was apparent, but not statistically significant, in females. Dietary exposure to 200 or 750 ppm nonylphenol had no significant effects in males or females. These results suggest that dietary genistein exposure may act similarly to estradiol in augmenting amphetamine-stimulated DA release.
KW - animal models
KW - diet
KW - dopamine
KW - estradiol
KW - females
KW - genistein
KW - homovanillic acid
KW - males
KW - ovariectomized females
KW - sex differences
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - nonylphenols
KW - oestradiol
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023166851&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9X-44R2T3Y-2&_user=10&_coverDate=02%2F28%2F2002&_rdoc=5&_fmt=summary&_orig=browse&_srch=%23toc%235126%232002%23999759998%23283738!&_cdi=5126&_sort=d&_docanchor=&wchp=dGLbVtb-lSzBk&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e93f03cd688102193c5c0281eb2d6f42
UR - email: sferguson@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Practicing palliative care in resource-poor settings.
AU - O'Neill, J. F.
AU - Romaguera, R.
AU - Parham, D.
T3 - Special issue: International progress in pain management and palliative care 2002.
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
Y1 - 2002///
VL - 24
IS - 2
SP - 148
EP - 151
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0885-3924
AD - O'Neill, J. F.: United States Department of Health and Human Services, Health Resources and Services Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033161472. Publication Type: Journal Article. Note: Special issue: International progress in pain management and palliative care 2002. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - In this article, the US Department of Health and Human Services' Health Resources and Services Administration (HRSA) addresses some of the issues regarding the best approaches in delivering palliative care and hospice within resource-poor settings. A definition of palliative care is given by HRSA. One international hospice model illustrating linkage between palliative care and treatment is described. The advantages of incorporating palliative care into international human immunodeficiency virus infection care are discussed.
KW - health care
KW - HIV infections
KW - hospice care
KW - human diseases
KW - human immunodeficiency viruses
KW - less favoured areas
KW - patient care
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - less favored areas
KW - low income areas
KW - problem areas
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033161472&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regional variation in cardiovascular disease risk factors among American Indians and Alaska Natives with diabetes.
AU - Rith-Najarian, S. J.
AU - Gohdes, D. M.
AU - Shields, R.
AU - Skipper, B.
AU - Moore, K. R.
AU - Tolbert, B.
AU - Raymer, T.
AU - Acton, K. J.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2002///
VL - 25
IS - 2
SP - 279
EP - 283
CY - Alexandria; USA
PB - American Diabetes Association, Inc.
SN - 0149-5992
AD - Rith-Najarian, S. J.: Bemidji Area Indian Health Service Diabetes Program, Room 115 Federal Building, 522 Minnesota Ave., Bemidji, MN 56601, USA.
N1 - Accession Number: 20023163139. Publication Type: Journal Article. Language: English. Registry Number: 57-88-5. Subject Subsets: Public Health; Human Nutrition
N2 - Objective: To compare by region risk factors for cardiovascular disease among American Indian populations with diabetes. Research Design and Methods: Trained providers from 185 federal, urban and tribally operated facilities reviewed the records from systematic random samples of the patients included in the local diabetes registries in the 1998 Indian Health Service (IHS) Diabetes Care and Outcomes Audit in USA. Selected measures of cardiovascular risk were aggregated by region and adjusted to calculate regional rates for patients <45 years of age (n=2595) and those aged ≥45 years (n=8294). Results: Among the younger group of patients with diabetes, the rates of elevated HbA1c(≥9%) and tobacco use varied significantly among regions. High rates of obesity (78%) and elevated HbA1c (56%) were found in the Southwest. High rates of tobacco use (55%) but the lowest rates of elevated HbA1c (27%) were found in Alaska. Among patients aged ≥45 years, all measures including rates of proteinuria, cholesterol ≥200 mg/dl, and mean blood pressure ≥130/85 varied significantly among all regions. Tobacco use was highest in the Great Lakes (44%) and Great Plains (42%) regions and lowest in the Southwest (14%) and Colorado Plateau (8%) regions. Proteinuria was found most frequently in the Southwest (35%), Colorado Plateau (30%) and Pacific regions (35%). Older individuals with diabetes were more likely than younger individuals to have proteinuria and blood pressure ≥130/85. Conclusions: American Indians and Alaska Natives with diabetes carry a large burden of potentially modifiable cardiovascular risk factors, but there is significant regional variation.
KW - Alaska Natives
KW - American indians
KW - blood pressure
KW - cardiovascular diseases
KW - cholesterol
KW - diabetes
KW - ethnic groups
KW - geographical variation
KW - human diseases
KW - obesity
KW - proteinuria
KW - risk
KW - risk factors
KW - tobacco smoking
KW - Alaska
KW - Colorado
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Mountain States of USA
KW - fatness
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023163139&site=ehost-live&scope=site
UR - email: srithnajrian@nchs.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Depletion of residues of furosemide, a loop diuretic, in lactating dairy cows.
AU - Shaikh, B.
AU - O'Driscoll, J. L.
AU - Cullison, R.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 2002///
VL - 25
IS - 5
SP - 387
EP - 388
CY - Oxford; UK
PB - Blackwell Science
SN - 0140-7783
AD - Shaikh, B.: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20023179801. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 54-31-9. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - The depletion of furosemide in milk in six lactating Holstein cows (2-7 years of age) was investigated. Each of the cows was intravenously injected with 10 ml of furosemide solution (5% Lasix, 50 mg/ml) once a day for 3 consecutive days. The highest concentration of furosemide in milk was reached during the first sampling 10 h after dosing (148.6 ng/ml average, 82.5-234.7 ng/ml range). Furosemide was detected in milk up to 23 h (8 ng/ml average, 3.3-12.6 ng/ml range), but no longer detected by 34 h postdose. The residue concentrations in 23 h postdose milk were below the safe level of 10 ppb for all but one cow. The coefficient of variation in the residue concentrations between the cows at 10 and 23 h were 39 and 42%, respectively, indicating significant variation. There was a poor correlation between milk production and furosemide concentration at 23 h (r2=0.345) and at 10 h (r2=0.093). Similarly, the correlation coefficients for days in milking versus furosemide concentration at 23 and 10 h were 0.309 and 0.052, respectively. Thus, it is more likely that the differences in the residue concentrations between cows are due to other interindividual factors, such as weight and age. The results suggest a rapid depletion of furosemide from lactating cows, which is in agreement with the results of previous work in one cow.
KW - cows
KW - dairy cows
KW - diuretics
KW - drug residues
KW - food contamination
KW - furosemide
KW - lactation
KW - milk
KW - pharmacokinetics
KW - pharmacology
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Dairy Animals (LL110)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023179801&site=ehost-live&scope=site
UR - email: bshaik@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - How effectively is epidemiological surveillance used for dengue programme planning and epidemic response?
AU - Gubler, D. J.
JO - Dengue Bulletin
JF - Dengue Bulletin
Y1 - 2002///
VL - 26
SP - 96
EP - 106
CY - New Delhi; India
PB - World Health Organization Regional Office for South-East Asia
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centres for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20033139513. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology; Tropical Diseases
N2 - Most dengue-endemic countries classify dengue/dengue haemorrhagic fever (DF/DHF) as a high priority disease in their planning and response documents. Very few of them, however, allocate the resources required to deal with DF/DHF as a high priority disease. A review of the surveillance activities in dengue-endemic countries and how surveillance data are used for planning and response revealed that few of them had effective surveillance systems for DF/DHF, and even fewer used available surveillance data in an effective manner for planning and response. The surveillance systems in selected countries with good surveillance are reviewed here. Issues of active vs passive surveillance and case definitions for DF and DHF are discussed, and recommendations made to improve the use of surveillance for planning and response.
KW - control programmes
KW - dengue
KW - dengue haemorrhagic fever
KW - disease control
KW - disease vectors
KW - epidemics
KW - epidemiology
KW - human diseases
KW - dengue virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - control programs
KW - dengue hemorrhagic fever
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033139513&site=ehost-live&scope=site
UR - email: djg2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An immunohistochemical label to facilitate counting of ovarian follicles.
AU - Muskhelishvili, L.
AU - Freeman, L. D.
AU - Latendresse, J. R.
AU - Bucci, T. J.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2002///
VL - 30
IS - 3
SP - 400
EP - 402
CY - Lawrence; USA
PB - Society of Toxicologic Pathologists
SN - 0192-6233
AD - Muskhelishvili, L.: Pathology Associates-A Charles River Company, National Center for Toxicological Research, 3900 NCTR Road, MC 923, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023197243. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2.
N2 - U.S. and internationally harmonized Health Effects Test Guidelines for Reproduction and Fertility Effects include enumeration of primordial and developing ovarian follicles as endpoints of safety tests, and the number of these structures is also of interest for other aspects of reproductive biology. Performing the counts microscopically on representative haematoxylin and eosin (H&E)-stained sections of ovary is tedious and error-prone. The ability to mark oocyte nuclei distinctly with an antibody significantly increases speed and accuracy of counting. We have identified a rabbit polyclonal antibody directed against a synthetic 14-amino acid sequence from human cytochrome P-450 1B1 (CYP1B1) that unequivocally marks rodent oocyte nuclei, in addition to nuclei of some ovarian granulosa and theca cells. Follicles of all degrees of maturity are easily distinguished from ovarian background; ability to detect and identify primordial follicles is particularly enhanced. High-contrast and high-resolution labelling was achieved with routine immunohistochemical procedures using an avidin-biotin-peroxidase method on rat and mouse tissues fixed in 10% neutral buffered formalin.
KW - amino acid sequences
KW - animal models
KW - cytochrome P-450
KW - fertility
KW - immunohistochemistry
KW - oocytes
KW - ovarian follicles
KW - ovaries
KW - reproduction
KW - women
KW - man
KW - rabbits
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - protein sequences
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023197243&site=ehost-live&scope=site
UR - email: lmuskhelishvili@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization and comparison of commercially available German and American cockroach allergen extracts.
AU - Patterson, M. L.
AU - Slater, J. E.
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
Y1 - 2002///
VL - 32
IS - 5
SP - 721
EP - 727
CY - Oxford; UK
PB - Blackwell Science
SN - 0954-7894
AD - Patterson, M. L.: Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Regulation and Research, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike (HFM-422), Rockville, Bethesda, MD 20852, USA.
N1 - Accession Number: 20023086443. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Background: In this study, we examine the variability among unstandardized cockroach allergen extracts. Methods: We obtained 24 aqueous and glycerinated cockroach allergen extracts from nine manufacturers. We used previously characterized cockroach extracts, E2-Cg and E2-Ca, as references. The modified ninhydrin assay was used to determine protein concentration of each extract. Relative potencies of extracts were determined by competition ELISA, using a human allergic serum pool. Bla g 1 and Bla g 2 levels of glycerinated German cockroach (Blattella germanica) extracts were determined by ELISA using monoclonal antibodies. Extracts were also analysed by SDS-PAGE. Results: Commercial cockroach allergen extracts had highly variable protein contents that were lower than the protein contents of the references. Electrophoretic data confirmed the presence of a variable number and intensity of protein bands in extracts among manufacturers. The relative potencies of the commercial extracts were between 10 and 782 BAU/ml for German cockroach and 10-250 BAU/ml for American cockroach (Periplaneta americana). The mean Bla g 1 content of the commercial extracts was significantly lower than that of the reference (P=0.001). The mean Bla g 2 content of the commercial extracts was higher than that of the E2-Cg reference but the Bla g 2 levels were more variable compared to Bla g 1. In glycerinated German cockroach extracts, protein concentrations, relative potencies and specific allergen levels were significantly correlated (P<0.001). Conclusion: Our tests indicate that commercially available cockroach allergen extracts are variable in protein content, electrophoretic banding patterns, relative potency and Bla g 2 levels. In glycerinated German cockroach extracts, protein concentrations, relative potencies and specific allergen levels are significantly correlated.
KW - allergens
KW - extracts
KW - potency
KW - protein content
KW - Blattaria
KW - Blattella germanica
KW - Periplaneta americana
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Blattella
KW - Blattellidae
KW - Periplaneta
KW - Blattidae
KW - American cockroach
KW - Blattodea
KW - German cockroach
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023086443&site=ehost-live&scope=site
UR - email: pattersonm@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Host adaptation and host-parasite co-evolution in Cryptosporidium: implications for taxonomy and public health.
AU - Xiao, L. H.
AU - Sulaiman, I. M.
AU - Ryan, U. M.
AU - Zhou, L.
AU - Atwill, E. R.
AU - Tischler, M. L.
AU - Zhang XiChen
AU - Fayer, R.
AU - Lal, A. A.
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 2002///
VL - 32
IS - 14
SP - 1773
EP - 1785
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0020-7519
AD - Xiao, L. H.: Division of Parasitic Diseases, Mail Stop F-12, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023199234. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 63231-63-0. Subject Subsets: Protozoology
N2 - To assess the genetic diversity and evolution of Cryptosporidium parasites, the partial ssrRNA, actin, and 70 kDa heat shock protein (HSP70) genes of 15 new Cryptosporidium parasites were sequenced. Sequence data were analysed together with those previously obtained from other Cryptosporidium parasites (10 Cryptosporidium spp. and eight Cryptosporidium genotypes). Results of this multi-locus genetic characterisation indicate that host adaptation is a general phenomenon in the genus Cryptosporidium, because specific genotypes were usually associated with specific groups of animals. On the other hand, host-parasite co-evolution is also common in Cryptosporidium, as closely related hosts usually had related Cryptosporidium parasites. Results of phylogenetic analyses suggest that the Cryptosporidium parvum bovine genotype and Cryptosporidium meleagridis were originally parasites of rodents and mammals, respectively, but have subsequently expanded their host ranges to include humans. Understanding the evolution of Cryptosporidium species is important not only for clarification of the taxonomy of the parasites but also for assessment of the public health significance of Cryptosporidium parasites from animals. Nucleotide sequences data reported in this paper are available in the GenBank, EMBL and DDBJ databases under the accession numbers AY120901-AY120932.
KW - adaptation
KW - evolution
KW - genes
KW - genetic diversity
KW - genotypes
KW - heat shock proteins
KW - host parasite relationships
KW - hosts
KW - nucleotide sequences
KW - phylogenetics
KW - RNA
KW - taxonomy
KW - Cryptosporidium
KW - Cryptosporidium parvum
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cryptosporidium
KW - Cryptosporidium meleagridis
KW - DNA sequences
KW - parasite host relationships
KW - ribonucleic acid
KW - systematics
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023199234&site=ehost-live&scope=site
UR - email: lax0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The global emergence/resurgence of arboviral diseases as public health problems.
AU - Gubler, D. J.
T3 - Special Issue: Current topics in tropical diseases
JO - Archives of Medical Research
JF - Archives of Medical Research
Y1 - 2002///
VL - 33
IS - 4
SP - 330
EP - 342
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0188-4409
AD - Gubler, D. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20023157805. Publication Type: Journal Article. Note: Special Issue: Current topics in tropical diseases Language: English. Number of References: 78 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology; Veterinary Science; Tropical Diseases; Veterinary Science
N2 - During the past 20 years there has been a dramatic resurgence or emergence of epidemic arboviral diseases affecting both humans and domestic animals. These epidemics have been caused primarily by viruses thought to be under control such as dengue, Japanese encephalitis, yellow fever, and Venezuelan equine encephalitis, or viruses that have expanded their geographic distribution such as West Nile and Rift Valley fever. Several of these viruses are presented as case studies to illustrate the changing epidemiology. The factors responsible for the dramatic resurgence of arboviral diseases in the waning years of the 20th century are discussed, as is the need for rebuilding the public health infrastructure to deal with epidemic vector-borne diseases in the 21st century.
KW - arboviruses
KW - dengue
KW - emerging infectious diseases
KW - epidemiology
KW - human diseases
KW - Japanese encephalitis
KW - Rift Valley fever
KW - West Nile fever
KW - yellow fever
KW - dengue virus
KW - Japanese encephalitis virus
KW - man
KW - Rift Valley fever virus
KW - Venezuelan equine encephalitis virus
KW - West Nile virus
KW - yellow fever virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Phlebovirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - arthropod-borne viruses
KW - emerging diseases
KW - emerging infections
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157805&site=ehost-live&scope=site
UR - email: dgubler@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of Artemisia capillaris Thunberg on the plasma and liver lipid metabolism in rats.
AU - Lee HyoungJa
AU - Hwang EunHee
JO - Korean Journal of Nutrition
JF - Korean Journal of Nutrition
Y1 - 2002///
VL - 35
IS - 4
SP - 421
EP - 430
CY - Seoul; Korea Republic
PB - Korean Nutrition Society
SN - 0367-6463
AD - Lee HyoungJa: Department of Food Evaluation, Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20033031436. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 49 ref. Registry Number: 57-88-5. Subject Subsets: Aromatic & Medicinal Plants; Human Nutrition
N2 - This study was performed to investigate the influence of A. capillaris on plasma and liver lipid metabolism in male Sprague-Dawley rats. The rats were fed diets containing normal concentrations of fat or high concentrations of lard and two different preparations of A. capillaris - control diet (group C), 50 mg/kg body weight A. capillaris methanol extract (group M), 6 g/kg diet A. capillaris dried powder (group P), high lard control diet (group L), 50 mg/kg body weight A. capillaris with high lard (group LM) and 6 g/kg diet A. capillaris with high lard (group LP). The effects of A. capillaris on plasma total cholesterol, high-density lipoprotein (HDL) cholesterol, atherogenic index, triglyceride, plasma and liver peroxide contents, fatty acid composition of liver lipid, and the distribution of fat droplets in the liver was then determined. Supplementation of A. capillaris resulted in lower plasma cholesterol, atherogenic index and triglyceride, and higher HDL-cholesterol in rats fed high lard diets. However, these effects were not observed with low level of fat (groups C, M and P). The increased plasma and liver peroxides, saturated fatty acid composition of liver lipid, and the more frequent distribution of fat droplets in liver that resulted from feeding high lard diets could be reversed by feeding A. capillaris. These results suggest that A. capillaris can alter lipid metabolism in the plasma and liver.
KW - animal models
KW - atherogenesis
KW - cholesterol
KW - high density lipoprotein
KW - laboratory animals
KW - lipid metabolism
KW - lipid peroxides
KW - liver
KW - saturated fatty acids
KW - triacylglycerols
KW - Artemisia capillaris
KW - rats
KW - Artemisia
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - fat metabolism
KW - triglycerides
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033031436&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999.
AU - Trick, W. E.
AU - Fridkin, S. K.
AU - Edwards, J. R.
AU - Hajjeh, R. A.
AU - Gaynes, R. P.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2002///
VL - 35
IS - 5
SP - 627
EP - 630
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Trick, W. E.: Health Outcomes Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, MS E55, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20023154252. Publication Type: Journal Article. Corporate Author: USA, National Nosocomial Infections Surveillance System Hospitals Language: English. Number of References: 20 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - We describe the annual incidence of primary bloodstream infection (BSI) associated with Candida albicans and common non-albicans species of Candida among patients in intensive care units that participated in the National Nosocomial Infections Surveillance system from 1 January 1989 through 31 December 1999 in the USA. During the study period, there was a significant decrease in the incidence of C. albicans BSI (P<0.001) and a significant increase in the incidence of Candida glabrata [Torulopsis glabrata] BSI (P=0.05).
KW - candidosis
KW - disease incidence
KW - disease surveys
KW - human diseases
KW - nosocomial infections
KW - USA
KW - Candida albicans
KW - Candida glabrata
KW - man
KW - Candida
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Torulopsis
KW - Pezizomycotina
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - candidiasis
KW - disease surveillance
KW - fungus
KW - hospital infections
KW - Hyphomycetes
KW - Torulopsis glabrata
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023154252&site=ehost-live&scope=site
UR - email: rpg1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A derived association between ambient aerosol surface area and excess mortality using historic time series data.
AU - Maynard, A. D.
AU - Maynard, R. L.
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2002///
VL - 36
IS - 36/37
SP - 5561
EP - 5567
CY - Oxford; UK
PB - Pergamon Press
SN - 1352-2310
AD - Maynard, A. D.: US Department of Health and Human Services, Public Health Service, Centres for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20023187260. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - Although aerosol mass concentration is widely associated with ill health following inhalation, there is increasing evidence that it is a poor indicator of fine and ultrafine particle toxicity. Research has indicated that biological response to such particles is closely associated with particulate surface area, although no epidemiological data currently exist to validate the association. By applying a simple model to historic mass-based time series data, we have been able to estimate mortality rate as a function of ambient aerosol surface area (UK). Within the simplifying assumptions of the model, a linear association is indicated between mortality rate and surface area concentration for coalescing particles. The analysis also indicates the existence of a threshold aerosol concentration, below which particulate mass and surface area are linearly related. Below this threshold, we suggest that mass concentration measurements may provide a good indicator of health effects, although for high exposures found in the developing world and industry, the model indicates that aerosol exposure may be more appropriately characterized by surface area. Further experimental validation of the model should establish the applicability of derived relationships between aerosol mass and surface area concentration to ambient and occupational exposures.
KW - aerosols
KW - air pollutants
KW - air pollution
KW - health hazards
KW - mathematical models
KW - mortality
KW - particles
KW - surface area
KW - time series
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - atmospheric pollution
KW - Britain
KW - death rate
KW - United Kingdom
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023187260&site=ehost-live&scope=site
UR - email: zel5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Autosow raised miniature swine as a model for assessing the effects of dietary soy trypsin inhibitor.
AU - Garthoff, L. H.
AU - Henderson, G. R.
AU - Sager, A. O.
AU - Sobotka, T. J.
AU - O'Dell, R.
AU - Thorpe, C. W.
AU - Trotter, W. J.
AU - Bruce, V. R.
AU - Dallas, H. L.
AU - Poelma, P. L.
AU - Solomon, H. M.
AU - Bier, J. W.
AU - O'Donnell, M. W., Jr.
AU - Chi, R. K.
AU - Chirtel, S. J.
AU - Barton, C. N.
AU - Brown, L. H.
AU - Frattali, V. P.
AU - Khan, M. A.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2002///
VL - 40
IS - 4
SP - 487
EP - 500
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Garthoff, L. H.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicological Research and Nutritional Product Studies, Muirkirk Research Center, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20023063925. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Soyabeans; Human Nutrition; Pig Science
N2 - Toxicological effects of dietary soya trypsin inhibitor (TI) were assessed in male miniature swine, a model chosen for its similarities to human digestive physiology and anatomy. The TI preparation was extracted from defatted raw soya flour. From 1 through 5 weeks of age, piglets were automatically fed either a TI liquid diet (Autosow TI group (ASTI)) or a control liquid diet (Autosow control group (ASC)). From 6 to 39 weeks of age, these animals received either swine chow and TI or swine chow and control article. The TI diets were formulated to contain a TI activity of approximately 500 mg TI/100 g dry matter. A sow control (SC) group suckled from birth to 6 weeks of age and then fed as the ASC group with swine chow plus control article from 6 to 39 weeks of age. The SC piglets grew faster than ASC piglets during postnatal weeks 1 and 2; however, the ASC piglets were significantly heavier than the SC piglets (P=0.001) at 6 weeks of age. Compared with the ASC group, TI caused a moderate decrease in feed consumption and a moderate but reversible decrease in growth from 2 to 5 weeks of age, but not thereafter. Some control and TI-fed Autosow-reared piglets had loose faeces until 6 weeks of age; the effect was significantly greater in the TI-fed group. Otherwise, all swine were active and had normal appearance and behaviour.
KW - animal models
KW - diets
KW - faeces
KW - feed intake
KW - growth
KW - laboratory animals
KW - piglets
KW - soyabean flour
KW - trypsin inhibitors
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - feces
KW - hogs
KW - soybean flour
KW - swine
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063925&site=ehost-live&scope=site
UR - email: lgarthof@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pathological evaluation, clinical chemistry and plasma cholecystokinin in neonatal and young miniature swine fed soy trypsin inhibitor from 1 to 39 weeks of age.
AU - Garthoff, L. H.
AU - Henderson, G. R.
AU - Sager, A. O.
AU - Sobotka, T. J.
AU - Gaines, D. W.
AU - O'Donnell, M. W., Jr.
AU - Chi, R.
AU - Chirtel, S. J.
AU - Barton, C. N.
AU - Brown, L. H.
AU - Hines, F. A.
AU - Solomon, T.
AU - Turkleson, J.
AU - Berry, D.
AU - Dick, H.
AU - Wilson, F.
AU - Khan, M. A.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2002///
VL - 40
IS - 4
SP - 501
EP - 516
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Garthoff, L. H.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicological Research and Nutritional Product Studies, Muirkirk Research Center, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20023063928. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 9002-76-0, 9011-97-6. Subject Subsets: Soyabeans; Human Nutrition; Pig Science
N2 - The potential toxicity of dietary soya trypsin inhibitor (TI) was evaluated in neonatal miniature swine. From 1 to 6 weeks of age, two groups of male piglets were artificially reared in an Autosow and automatically fed either TI or control liquid diet. From 6 to 39 weeks of age, these two groups were fed either TI or control chow diet. A third group, sow control (SC), suckled from birth to 6 weeks of age, were also weaned to control chow from 6 to 39 weeks of age. Clinical chemistry and plasma cholecystokinin (CCK) determined at 6, 18, 30 and 39 weeks of age, and serum amylase activity with gross and histopathological analyses of major organs at 6 and 39 weeks of age are reported. TI had no effect on plasma CCK, serum amylase activity, or numerous clinical chemistry values. TI-fed piglets had a larger relative liver weight at 6 weeks of age. Relative pancreas weight decreased with age but was not affected by TI. Gross and histopathological analyses of major organs, except the spleen, were within normal limits. Increased incidence of extramedullary haematopoiesis was noted in the spleen of the TI group at 6 but not at 39 weeks of age. There was no consistent pattern in immunohistochemical foci for secretin, gastrin releasing polypeptide or CCK, and no change in DNA, RNA, mitotic index or nuclear density of pancreatic cells. At 6 weeks of age, TI increased pancreatic protein and amylase activity but not trypsin or chymotrypsin activity. None of the effects suggested that this dose of TI was toxic to either the neonatal or sexually mature miniature male swine.
KW - animal models
KW - gastrin
KW - laboratory animals
KW - newborn animals
KW - pancreas
KW - pancreozymin
KW - piglets
KW - soyabean products
KW - toxicity
KW - trypsin inhibitors
KW - pigs
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cholecystokinin
KW - hogs
KW - soybean products
KW - swine
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063928&site=ehost-live&scope=site
UR - email: lgarthof@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures.
AU - Plakas, S. M.
AU - El-Said, K. R.
AU - Jester, E. L. E.
AU - Granade, H. R.
AU - Musser, S. M.
AU - Dickey, R. W.
JO - Toxicon
JF - Toxicon
Y1 - 2002///
VL - 40
IS - 6
SP - 721
EP - 729
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0041-0101
AD - Plakas, S. M.: Gulf Coast Seafood Laboratory, US Food and Drug Administration, 1 Iberville Drive, P.O. Box 158, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20023087076. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 52-90-4. Subject Subsets: Protozoology
N2 - Previously, we analysed Eastern oysters (Crassostrea virginica) naturally exposed to a Karenia brevis red tide and found that brevetoxins (PbTx) are rapidly accumulated and metabolized. Several metabolites were isolated and later identified, including a cysteine-PbTx conjugate (MH+: m/z 1018) and its sulfoxide product (m/z 1034). In the present study, we confirm and extend those findings by examining PbTx metabolism and elimination in oysters exposed to pure toxins (PbTx-2 and -3) under controlled conditions. Waterborne PbTx-3 was rapidly accumulated, but not metabolized, in the oyster and was largely eliminated within 2 weeks after exposure. In contrast, PbTx-2 was accumulated and rapidly metabolized. Metabolites of PbTx-2 included the reduction product PbTx-3 (m/z 897), and the cysteine conjugates (m/z 1018 and 1034) isolated previously from the field samples. Levels of the metabolite PbTx-3 in PbTx-2-exposed oysters were highest immediately after exposure and declined at a rate similar to parent PbTx-3 in PbTx-3-exposed oysters. Cysteine-PbTx persisted for 8 weeks after exposure. The same metabolites were confirmed in oysters exposed to laboratory cultures of K. brevis. PbTx metabolites contribute to neurotoxic shellfish poisoning (NSP) and should be included in analytical protocols for monitoring shellfish toxicity after a K. brevis red tide event.
KW - cysteine
KW - metabolism
KW - metabolites
KW - oysters
KW - paralytic shellfish poisoning
KW - toxins
KW - Crassostrea virginica
KW - Dinoflagellida
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Crassostrea
KW - Ostreidae
KW - Sarcomastigophora
KW - Protozoa
KW - Gymnodiniaceae
KW - Gymnodiniales
KW - brevetoxins
KW - Karenia
KW - Karenia brevis
KW - Myzozoa
KW - Aquatic Biology and Ecology (MM300)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023087076&site=ehost-live&scope=site
UR - email: splakas@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of West Nile virus antigen in mosquitoes and avian tissues by a monoclonal antibody-based capture enzyme immunoassay.
AU - Hunt, A. R.
AU - Hall, R. A.
AU - Kerst, A. J.
AU - Nasci, R. S.
AU - Savage, H. M.
AU - Panella, N. A.
AU - Gottfried, K. L.
AU - Burkhalter, K. L.
AU - Roehrig, J. T.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2002///
VL - 40
IS - 6
SP - 2023
EP - 2030
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Hunt, A. R.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522-2087, USA.
N1 - Accession Number: 20023103064. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Medical & Veterinary Entomology; Poultry
N2 - An antigen capture immunoassay to detect West Nile (WN) virus antigen in infected mosquitoes and avian tissues has been developed. With this assay purified WN virus was detected at a concentration of 32 pg/0.1 ml, and antigen in infected suckling mouse brain and laboratory-infected mosquito pools could be detected when the WN virus titre was 102.1 to 103.7 PFU/0.1 ml. In a blindly coded set of field-collected mosquito pools (n=100), this assay detected WN virus antigen in 12 of 18 (66.7%) TaqMan-positive pools, whereas traditional reverse transcriptase PCR detected 10 of 18 (55.5%) positive pools. A sample set of 73 organ homogenates from naturally infected American crows was also examined by WN virus antigen capture immunoassay and TaqMan for the presence of WN virus. The antigen capture assay detected antigen in 30 of 34 (88.2%) TaqMan-positive tissues. Based upon a TaqMan-generated standard curve of infectious WN virus, the limit of detection in the antigen capture assay for avian tissue homogenates was approximately 103 PFU/0.1 ml. The recommended WN virus antigen capture protocol, which includes a capture assay followed by a confirmatory inhibition assay used to retest presumptive positive samples, could distinguish between the closely related WN and St. Louis encephalitis viruses in virus-infected mosquito pools and avian tissues. Therefore, this immunoassay demonstrates adequate sensitivity and specificity for surveillance of WN virus activity in mosquito vectors and avian hosts, and, in addition, it is easy to perform and relatively inexpensive compared with the TaqMan assay.
KW - antigen testing
KW - disease vectors
KW - enzyme immunoassay
KW - viral antigens
KW - Corvus
KW - Culicidae
KW - West Nile virus
KW - Corvidae
KW - Passeriformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigen detection
KW - antigen tests
KW - mosquitoes
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023103064&site=ehost-live&scope=site
UR - email: arh4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and differentiation of Cryptosporidium parasites that are pathogenic for humans by real-time PCR.
AU - Limor, J. R.
AU - Lal, A. A.
AU - Xiao, L. H.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2002///
VL - 40
IS - 7
SP - 2335
EP - 2338
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Limor, J. R.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023117795. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology; Public Health
N2 - Cryptosporidiosis is a significant cause of food-borne and waterborne outbreaks of diarrhoeal diseases. To better understand the route of transmission of Cryptosporidium parasites, a number of genotyping techniques have been developed, based on PCR-restriction fragment length polymorphism or sequencing analysis of antigen, structural, and housekeeping genes. In this study, a real-time assay for the detection of Cryptosporidium oocysts is described. This technique had a detection limit of five oocysts. By melting curve analysis of PCR products with fluorescence-labeled hybridization probes, this technique was able to differentiate five common Cryptosporidium parasites that are pathogenic for humans in a single PCR. We evaluated and validated the test using samples from presently known Cryptosporidium parasites that are pathogenic for humans. Parasites used included C. parvum human, bovine, mouse and marsupial genotypes; C. wrairi; C. meleagridis; C. felis; C. canis; C. baileyi; C. andersoni; and C. serpentis. All of the isolates used in the study were from naturally-infected animals or humans, or humans except for C. meleagridis, which was isolated from a turkey and passed through 1- to 2-week-old turkey poults. Results show that the technique provides an alternative molecular tool in epidemiological studies of human cryptosporidiosis.
KW - cryptosporidiosis
KW - detection
KW - genotypes
KW - human diseases
KW - molecular genetics
KW - oocysts
KW - polymerase chain reaction
KW - Cryptosporidium baileyi
KW - Cryptosporidium parvum
KW - man
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - biochemical genetics
KW - Cryptosporidium andersoni
KW - Cryptosporidium canis
KW - Cryptosporidium felis
KW - Cryptosporidium meleagridis
KW - Cryptosporidium serpentis
KW - Cryptosporidium wrairi
KW - PCR
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023117795&site=ehost-live&scope=site
UR - email: lax0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and genotyping of human group A rotaviruses by oligonucleotide microarray hybridization.
AU - Chizhikov, V.
AU - Wagner, M.
AU - Ivshina, A.
AU - Hoshino, Y.
AU - Kapikian, A. Z.
AU - Chumakov, K.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2002///
VL - 40
IS - 7
SP - 2398
EP - 2407
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Chizhikov, V.: Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD 20895, USA.
N1 - Accession Number: 20023117800. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - A rapid and reliable method for the identification of five clinically relevant G genotypes (G1 to G4 and G9) of human rotaviruses based on oligonucleotide microarray hybridization was developed. The genotype-specific oligonucleotides immobilized on the surface of glass slides were selected to bind to the multiple target regions within the VP7 gene that are highly conserved among individual rotavirus genotypes. Rotavirus cDNA was amplified in a PCR with primers common to all group A rotaviruses. A second round of nested PCR amplification was performed in the presence of indodicarbocyanine-dCTP and another pair of degenerate primers also broadly specific for all genotypes. The use of one primer containing 5′-biotin allowed us to prepare fluorescently labelled single-stranded hybridization probe by binding of another strand to magnetic beads. The identification of rotavirus genotype was based on hybridization with several individual genotype-specific oligonucleotides. This approach combines the high sensitivity of PCR with the selectivity of DNA-DNA hybridization. The specificity of oligonucleotide microchip hybridization was evaluated by testing 20 coded rotavirus isolates from different geographic areas for which genotypes were previously determined by conventional methods. Analysis of the coded specimens showed that this microarray-based method is capable of unambiguous identification of all rotavirus strains. Because of the presence of random mutations, each individual virus isolate produced a unique hybridization pattern capable of distinguishing different isolates of the same genotype and, therefore, subgenotype differentiation. This strain information indicates one of several advantages that microarray technology has over conventional PCR techniques.
KW - complementary DNA
KW - genotypes
KW - molecular genetics
KW - oligonucleotides
KW - polymerase chain reaction
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - biochemical genetics
KW - cDNA
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023117800&site=ehost-live&scope=site
UR - email: chizhikov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Listeria species by microarray-based assay.
AU - Volokhov, D.
AU - Rasooly, A.
AU - Chumakov, K.
AU - Chizhikov, V.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2002///
VL - 40
IS - 12
SP - 4720
EP - 4728
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Volokhov, D.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033014793. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - We have developed a rapid microarray-based assay for the reliable detection and discrimination of six species of the Listeria genus: L. monocytogenes, L. ivanovii, L. innocua, L. welshimeri, L. seeligeri, and L. grayi. The approach used in this study involves one-tube multiplex PCR amplification of six target bacterial virulence factor genes (iap, hly, inlB, plcA, plcB, and clpE), synthesis of fluorescently labelled single-stranded DNA, and hybridization to the multiple individual oligonucleotide probes specific for each Listeria species and immobilized on a glass surface. Results of the microarray analysis of 53 reference and clinical isolates of Listeria spp. demonstrated that this method allowed unambiguous identification of all six Listeria species based on sequence differences in the iap gene. Another virulence factor gene, hly, was used for detection and genotyping all L. monocytogenes, all L. ivanovii, and 8 of 11 L. seeligeri isolates. Other members of the genus Listeria and three L. seeligeri isolates did not contain the hly gene. There was complete agreement between the results of genotyping based on the hly and iap gene sequences. All L. monocytogenes isolates were found to be positive for the inlB, plcA, plcB, and clpE virulence genes specific only to this species. Our data on Listeria species analysis demonstrated that this microarray technique is a simple, rapid, and robust genotyping method that is also a potentially valuable tool for identification and characterization of bacterial pathogens in general.
KW - genes
KW - methodology
KW - virulence
KW - Listeria
KW - Listeria grayi
KW - Listeria innocua
KW - Listeria ivanovii
KW - Listeria monocytogenes
KW - Listeria seeligeri
KW - Listeria welshimeri
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - methods
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033014793&site=ehost-live&scope=site
UR - email: chizhikov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a binding site for ganglioside on the receptor binding domain of tetanus toxin.
AU - Louch, H. A.
AU - Buczko, E. S.
AU - Woody, M. A.
AU - Venable, R. M.
AU - Vann, W. F.
JO - Biochemistry (Washington)
JF - Biochemistry (Washington)
Y1 - 2002///
VL - 41
IS - 46
SP - 13644
EP - 13652
CY - Washington; USA
PB - American Chemical Society
SN - 0006-2960
AD - Louch, H. A.: Laboratory of Bacterial Toxins, Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Federal Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033136632. Publication Type: Journal Article. Language: English. Registry Number: 56-84-8, 71-00-1, 73-22-3. Subject Subsets: Public Health
N2 - The carboxyl-terminal region of the tetanus toxin heavy chain (HC fragment) binds to di- and trisialylgangliosides on neuronal cell membranes. To determine which amino acids in tetanus toxin are involved in ganglioside binding, homology modelling was performed using recently resolved X-ray crystallographic structures of the tetanus toxin HC fragment. On the basis of these analyses, two regions in tetanus toxin that are structurally homologous with the binding domains of other sialic acid and galactose-binding proteins were targeted for mutagenesis. Specific amino acids within these regions were altered using site-directed mutagenesis. It was shown that the amino acid residue tryptophan 1288 was critical for binding of the HC fragment to ganglioside GT1b. Docking of GD1b within this region of the toxin suggested that histidine 1270 and aspartate 1221 were within hydrogen bonding distance of the ganglioside. These two residues were mutagenized and found also to be important for the binding of the tetanus toxin HC fragment to ganglioside GT1b. In addition, the HC fragments mutagenized at these residues have reduced levels of binding to neurites of differentiated PC-12 cells. These studies indicate that the amino acids tryptophan 1288, histidine 1270 and aspartate 1221 are components of the GT1b binding site on the tetanus toxin HC fragment.
KW - aspartic acid
KW - bacterial toxins
KW - binding sites
KW - gangliosides
KW - histidine
KW - mutagenesis
KW - mutants
KW - neurotoxins
KW - tryptophan
KW - Clostridium tetani
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - binding site
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033136632&site=ehost-live&scope=site
UR - email: wvann@helix.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical pharmacology of antimicrobial use in humans and animals.
AU - Lathers, C. M.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2002///
VL - 42
IS - 6
SP - 587
EP - 600
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 0091-2700
AD - Lathers, C. M.: Center of Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD 20855, USA.
N1 - Accession Number: 20033017845. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - Veterinary public health is a frontier in the fight against human disease, charged to control and eradicate zoonotic diseases that are naturally transmitted between vertebrate animals and man. Currently there is a need for clinical pharmacologists and all health care givers to limit the development of bacterial resistance in humans to contain the increased health care expenditures related to morbidity and mortality associated with the use of antimicrobials. The development of resistance predates the use of antibiotics and will always be a problem to the successful treatment of patients. Ongoing discussion debates the extent to which antibiotic use in animals contributes to the development of antibiotic resistance in humans. The veterinary use of antibiotics as antimicrobial growth promoters is thought to influence the prevalence of resistance in animal bacteria and to be a risk factor for the emergence of antibiotic resistance in human pathogens. Transfer of antibiotic resistant bacteria from animals to humans may occur via contact, including occupational exposure and via the food chain. Resistance genes may transfer from bacteria of animals to human pathogens in the intestinal flora of humans. Prevention of the development of resistance in humans necessitates good animal husbandry and hygienic measures to prevent cross contamination and a decrease in the use of antibiotics. Appropriate use of antibiotics for food animals will preserve the long-term efficacy of existing antibiotics, support animal health and welfare, and limit the risk of transfer of antibiotic resistance to humans. Investigators must also develop new antimicrobial agents. Poole recommends targeting the three predominate mechanisms of development of resistance by antimicrobials (i.e., antibiotic inactivation, target site modification, and altered uptake via restricted entry and/or enhanced efflux) to specifically complement the development of novel agents with novel bacterial targets. Bacterial resistance and its selection may be evaluated by comparing the relationship to antibiotic pharmacokinetic (PK) values obtained from serum concentrations and organism MICs (minimum inhibitory concentrations; concentration-dependent killing) to reveal culture and sensitivity tests in patients. Pharmacodynamic (PD) models may be developed to identify factors associated with the probability that bacterial resistance will develop. Thomas et al used this combined approach of PK/PD and MICs to examine data retrospectively. The role of clinical pharmacology is to work with PK/PD models such as these to determine the best use of antibiotics in humans to minimize the development of resistance. The role of any regulatory body responsible for the protection of the public health and food safety for consumers is to assess risk and to then communicate and manage the risk. Scientific uncertainty must be interpreted to propose sound policy options. The conversion of sound science into an appropriate regulatory policy to protect the public health is most important.
KW - antibiotics
KW - antiinfective agents
KW - costs
KW - disease control
KW - disease transmission
KW - drug resistance
KW - epidemiology
KW - growth promoters
KW - health care
KW - human diseases
KW - morbidity
KW - mortality
KW - pharmacodynamics
KW - pharmacokinetics
KW - pharmacology
KW - public health
KW - reviews
KW - risk
KW - risk factors
KW - zoonoses
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - costings
KW - death rate
KW - drug action
KW - growth stimulants
KW - mechanism of drug action
KW - zoonotic infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033017845&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk assessment in regulatory policy making for human and veterinary public health.
AU - Lathers, C. M.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2002///
VL - 42
IS - 8
SP - 846
EP - 866
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 0091-2700
AD - Lathers, C. M.: Center for Veterinary Medicine, U.S. Food and Drug Administration, Office of New Animal Drug Evaluation, 7500 Standish Place, Rm. 387, HFV-100, Rockville, MD 20855, USA.
N1 - Accession Number: 20023143538. Publication Type: Journal Article. Language: English. Number of References: 129 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Veterinary Science; Veterinary Science
N2 - Risk assessment is the method of systematically identifying and assessing factors that influence the probability and consequences of a negative event occurring. One responsibility of veterinary medicine is to protect animal and human health. Food animal production uses antibiotics to enhance production. Regulators evaluate new production technology to ensure animal safety and safe, edible products and to make public policy decisions by assessing risks/benefits. The U.S. Food and Drug Administration, Center for Veterinary Medicine's (CVM's) first risk assessment addressed the potential human health impact of campylobacter effects associated with the use of fluoroquinolines in food-producing animals. CVM used the Monte Carlo method to estimate risk by probability distributions that reflect the uncertainty and variability in the data used for the assessment. Enterococci faecium is a species more likely to be resistant to antibiotics of last resort. Effective control of multidrug-resistant enterococci will require a better understanding of the transfer of E. faecium from animals to humans and the interaction between E. faecium, the hospital environment, and humans; prudent antibiotic use; better contact isolation in hospitals; and better surveillance. CVM will model these factors in a second, more complex risk assessment designed to examine the indirect transfer of resistance from animals to humans. Use of risk assessments allows researchers, the industry, regulatory authorities, and educators to make better policy decisions regarding antimicrobial use in food animals and humans and the development of resistance. Today the question of whether the use of antimicrobials for growth enhancement in food animals should or should not be terminated for the benefit of human health remains unresolved.
KW - animal products
KW - antibiotic residues
KW - drug residues
KW - drug resistance
KW - drugs
KW - fluoroquinolones
KW - food safety
KW - health policy
KW - multiple drug resistance
KW - public health
KW - regulations
KW - risk
KW - risk assessment
KW - Campylobacter
KW - Enterococcus faecium
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - bacterium
KW - medicines
KW - pharmaceuticals
KW - rules
KW - Laws and Regulations (DD500)
KW - Policy and Planning (EE120)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023143538&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis.
AU - Shamim, E. A.
AU - Rider, L. G.
AU - Pandey, J. P.
AU - O'Hanlon, T. P.
AU - Jara, L. J.
AU - Samayoa, E. A.
AU - Burgos-Vargas, R.
AU - Vazquez-Mellado, J.
AU - Alcocer-Varela, J.
AU - Salazar-Paramo, M.
AU - Kutzbach, A. G.
AU - Malley, J. D.
AU - Targoff, I. N.
AU - Garcia-De La Torre, I.
AU - Miller, F. W.
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
Y1 - 2002///
VL - 46
IS - 7
SP - 1885
EP - 1893
CY - Atlanta; USA
PB - American College of Rheumatology Educational Foundation
SN - 0004-3591
AD - Shamim, E. A.: Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.
N1 - Accession Number: 20023128685. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases; Rural Development
N2 - Objective: As part of a larger, worldwide study of the ethnogeography of myositis, we evaluated the clinical, serologic, and immunogenetic features of Mestizo (Mexican and Guatemalan) and North American Caucasian patients with idiopathic inflammatory myopathy (IIM). Methods: Clinical manifestations, autoantibodies, HLA-DRB1 and DQA1 alleles, and immunoglobulin Gm/Km allotypes were compared between 138 Mestizos with IIM and 287 Caucasians with IIM, using the same classification criteria and standardized questionnaires. Results: IIM in Mestizo patients was characterized by a higher proportion of dermatomyositis (69% of adult Mestizos versus 35% of adult Caucasians; P<0.001) and anti-Mi-2 autoantibodies (30% versus 7% of adults, respectively, and 32% versus 4% of children, respectively; P<0.01). Genetic risk factors also differed in these populations. Whereas Mestizos had no HLA risk factors for IIM, HLA-DRB1*0301, the linked allele DQA1*0501, and DRB1 alleles sharing the first hypervariable region motif9EYSTS13 were major risk factors in Caucasian patients with IIM. Furthermore, different HLA-DRB1 and DQA1 alleles were associated with anti-Mi-2 autoantibodies (DRB1*04 and DQA1*03 in Mestizos and DRB1*07 and DQA1*02 in Caucasians). Immunoglobulin γ-chain allotypes Gm(1), Gm(17) (odds ratio for both 11.3, P=0.008), and Gm(21) (odds ratio 7.3, P=0.005) and κ-chain allotype Km(3) (odds ratio 7.3, P=0.005) were risk factors for IIM in Mestizos; however, no Gm or Km allotypes were risk or protective factors in Caucasians. In addition, Gm and Km phenotypes were unique risk factors (Gm 1,3,17 5,13,21 and Gm 1,17 23 21 and Km 3,3) or protective factors (Km 1,1) for the development of myositis and anti-Mi-2 autoantibodies (Gm 1,2,3,17 23 5,13,21) in adult Mestizos. Conclusion: IIM in Mesoamerican Mestizos differs from IIM in North American Caucasians in the frequency of phenotypic features and in the immune-response genes predisposing to and protecting from myositis and anti-Mi-2 autoantibodies at 4 chromosomal loci. These and other data suggest the likelihood that the expression of IIM is modulated by different genes and environmental exposures around the world.
KW - allotypes
KW - ethnicity
KW - genotypes
KW - human diseases
KW - myositis
KW - phenotypes
KW - Guatemala
KW - Maryland
KW - Mexico
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - ethnic differences
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023128685&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/96515790/START
UR - email: shamim@nichs.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor α antagonists infliximab and etanercept.
AU - Lee, J. H.
AU - Slifman, N. R.
AU - Gershon, S. K.
AU - Edwards, E. T.
AU - Schwieterman, W. D.
AU - Siegel, J. N.
AU - Wise, R. P.
AU - Brown, S. L.
AU - Udall, J. N., Jr.
AU - Braun, M. M.
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
Y1 - 2002///
VL - 46
IS - 10
SP - 2565
EP - 2570
CY - Atlanta; USA
PB - American College of Rheumatology Educational Foundation
SN - 0004-3591
AD - Lee, J. H.: Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20023178073. Publication Type: Journal Article. Language: English. Registry Number: 308079-78-9. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Objective: Two tumor necrosis factor α (TNFα) antagonists were recently licensed in the US. Infliximab was licensed in 1998 for the treatment of Crohn's disease (CD), and since 1999, it has been licensed in combination with methotrexate for treatment of rheumatoid arthritis (RA). Etanercept was licensed in 1998 for treatment of RA and, more recently, for juvenile RA and psoriatic arthritis. Because of potential immunosuppression related to use of anti-TNFα agents, we sought to identify postlicensure cases of opportunistic infection, including histoplasmosis, in patients treated with these products. Methods: The US Food and Drug Administration's (FDA) passive surveillance database for monitoring postlicensure adverse events was reviewed to identify all reports received through July 2001 of histoplasmosis in patients treated with either infliximab or etanercept. Results: Ten cases of Histoplasma capsulatum (HC) infection were reported: 9 associated with infliximab and 1 associated with etanercept. In patients treated with infliximab, manifestations of histoplasmosis occurred within 1 week to 6 months after the first dose and typically included fever, malaise, cough, dyspnea, and interstitial pneumonitis. Of the 10 patients with histoplasmosis, 9 required treatment in an intensive care unit, and 1 died. All patients had received concomitant immunosuppressive medications in addition to infliximab or etanercept, and all resided in HC-endemic regions. Conclusion: Postlicensure surveillance suggests that acute life-threatening histoplasmosis may complicate immunotherapy with TNFα antagonists, particularly infliximab. Histoplasmosis should be considered early in the evaluation of patients who reside in HC-endemic areas in whom infectious complications develop during treatment with infliximab or etanercept.
KW - adverse effects
KW - antagonists
KW - histoplasmosis
KW - human diseases
KW - immunocompromised hosts
KW - immunotherapy
KW - opportunistic infections
KW - tumour necrosis factor
KW - Histoplasma capsulatum
KW - man
KW - Ajellomyces
KW - Ajellomycetaceae
KW - Onygenales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Histoplasma
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - adverse reactions
KW - Ajellomyces capsulatus
KW - cachectin
KW - cachexin
KW - fungus
KW - tumor necrosis factor
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023178073&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/99017597/START
UR - email: braunm@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of vat(E) in Enterococcus faecalis isolates from retail poultry and its transferability to Enterococcus faecium.
AU - Simjee, S.
AU - White, D. G.
AU - Wagner, D. D.
AU - Meng, J.
AU - Qaiyumi, S.
AU - Zhao, S.
AU - McDermott, P. F.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2002///
VL - 46
IS - 12
SP - 3823
EP - 3828
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Simjee, S.: U.S. Food and Drug Administration Center for Veterinary Medicine, 8401 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20023187649. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 114-07-8, 57-92-1, 60-54-8, 64-75-5. Subject Subsets: Poultry; Veterinary Science; Veterinary Science; Public Health
N2 - 16 isolates of Enterococcus faecalis were recovered from retail poultry samples (7 chickens and 9 turkeys) purchased from grocery stores in the greater Washington, D.C., area in the USA. Polymerase chain reaction (PCR) for known streptogramin resistance genes identified vat(E) in 5 E. faecalis isolates (3 isolates from chickens and 2 isolates from turkeys). The vat(E) gene was transmissible on a ca. 70-kb plasmid, along with resistance to erythromycin, tetracycline, and streptomycin, by conjugation to E. faecalis and E. faecium recipient strains. DNA sequencing showed little variation between E. faecalis vat(E) genes from the chicken samples; however, one E. faecalis vat(E) gene from a turkey sample possessed 5 nucleotide changes that resulted in 4 amino acid substitutions. None of these substitutions in the vat(E) allele have previously been described. This is the first report of vat(E) in E. faecalis and its transferability to E. faecium, which indicates that E. faecalis can act as a reservoir for the dissemination of vat(E)-mediated streptogramin resistance to E. faecium.
KW - drug resistance
KW - erythromycin
KW - genes
KW - human diseases
KW - identification
KW - polymerase chain reaction
KW - poultry
KW - poultry meat
KW - streptomycin
KW - tetracycline
KW - District of Columbia
KW - USA
KW - Enterococcus faecalis
KW - Enterococcus faecium
KW - fowls
KW - man
KW - turkeys
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Meleagris
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - bacterium
KW - chickens
KW - domesticated birds
KW - PCR
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023187649&site=ehost-live&scope=site
UR - email: ssimjee@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining dioxin-like compounds in selected Korean food.
AU - Choi Dongmi
AU - Hu Soojung
AU - Jeong Jiyoon
AU - Won Kyungpoong
AU - Song Insang
A2 - Fiedler, H.
A2 - Denison, M.
A2 - Jones, K. C.
A2 - Hutzinger, O.
A2 - Louw, R.
A2 - Needham, L. L.
A2 - Patterson, D. G., Jr.
A2 - Rappe, C.
A2 - Safe, S. H.
JO - Chemosphere
JF - Chemosphere
Y1 - 2002///
VL - 46
IS - 9/10
SP - 1423
EP - 1427
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0045-6535
AD - Choi Dongmi: Department of Food Evaluation, Korea Food and Drug Administration, #5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20023061707. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science; Pig Science
N2 - To measure the levels of dioxin-like compounds, pork, mackerel, cheese and milk were analysed. The food samples were obtained at three different markets in Seoul. All the samples were animal origin and their lipid contents ranged from 4% to 34%. After extraction, extracts were cleaned up by sulfuric acid impregnated silica gel, purified on a series of silica gel, alumina, carbon column chromatography and then analysed by high resolution gas chromatography/high resolution mass spectrometry. The levels of polychlorinated dibenzo-p-dioxins/furans for pork, mackerel, cheese and milk were 0.0008, 0.8663, 0.002 and 0.0236 pgTEQ/g wet weight, respectively. In addition, the levels of non-ortho coplanar polychlorinated biphenyls for pork, mackerel, cheese and milk were 0.0041, 1.5781, 0.0259 and 0.0353 pgTEQ/g wet weight, respectively. Among food samples analysed, pork showed the lowest level of dioxin-like compounds.
KW - cheeses
KW - dioxins
KW - food contamination
KW - lipids
KW - milk
KW - pigmeat
KW - polychlorinated biphenyls
KW - polychlorinated dibenzodioxins
KW - polychlorinated dibenzofurans
KW - Korea Republic
KW - mackerels
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - food contaminants
KW - lipins
KW - PCBs
KW - pork
KW - South Korea
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023061707&site=ehost-live&scope=site
UR - email: mechoi@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of fluoroquinolones in egg albumen and egg yolk of laying hens using fluorometric detection.
AU - Chu, P. S.
AU - Wang, R. C.
AU - Chu, H. V.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2002///
VL - 50
IS - 16
SP - 4452
EP - 4455
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Chu, P. S.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053077717. Publication Type: Journal Article. Language: English. Registry Number: 85721-33-1, 9006-50-2, 93106-60-6. Subject Subsets: Human Nutrition
N2 - A liquid chromatographic method was developed for the determination of ciprofloxacin, enrofloxacin, and sarafloxacin at 10-200 ppb in both egg yolk and egg albumen of laying hens. Egg yolk or albumen was acidified with 1 M phosphoric acid followed by deproteination with acetonitrile and centrifugation. The supernate was pipetted out, and the remaining protein pellet was extracted three times with acetonitrile. The supernates were combined and concentrated at 50°C to <0.7 mL. The final volume was adjusted to 2 mL with 0.02 M potassium phosphate buffer, pH 2.5. Separation of the analytes was achieved using reversed-phase HPLC with fluorometric detection. The recoveries were >80% and coefficients of variation <20%. After validation, the method was applied for use in a national survey for fluoroquinolones in table eggs. Of the 276 eggs assayed, none was found positive for fluoroquinolones. The findings suggest that illegal use of fluoroquinolones in laying hens is not widespread.
KW - ciprofloxacin
KW - egg albumen
KW - egg yolk
KW - enrofloxacin
KW - liquid chromatography
KW - egg white
KW - fluoroquinolone
KW - sarafloxacin
KW - yolk
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053077717&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2002/50/i16/abs/jf0202032.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolism of biochanin A and formononetin by human liver microsomes in vitro.
AU - Tolleson, W. H.
AU - Doerge, D. R.
AU - Churchwell, M. I.
AU - Marques, M. M.
AU - Roberts, D. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2002///
VL - 50
IS - 17
SP - 4783
EP - 4790
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Tolleson, W. H.: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053077627. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2, 486-66-8, 485-72-3, 446-72-0. Subject Subsets: Human Nutrition
N2 - Biochanin A and formononetin are abundant in legumes. These proestrogenic isoflavones can be converted by 4′-O-demethylation to the more potent phytoestrogens genistein and daidzein. Incubation of biochanin A or formononetin with human liver microsomes resulted in 4′-O-demethylation and the production of additional metabolites. Three new hydroxylated formononetin derivatives, 6,7-dihydroxy-4′-methoxyisoflavone, 7,8-dihydroxy-4′-methoxyisoflavone, and 7,3′-dihydroxy-4′-methoxyisoflavone, were isolated and characterized. We surveyed the O-demethylase competence of cytochrome P450 isoforms found in human liver. Human cytochrome P450 isoforms 1A2, 2E1, 2C9*1, 2C19, and 2D6*1 catalyzed biochanin A consumption and genistein production. Human cytochrome P450 isoforms 1A2, 2C9*1, 2A6, 2D6*1, and 2C19 catalyzed formononetin consumption and daidzein production. These isoforms also generated other hydroxylated metabolites. Although O-demethylation of isoflavones has been attributed to metabolism by gut microflora, our study demonstrates that human hepatic microsomal enzymes can perform the same transformation and may play a key role in the conversion of 4′-O-methylated isoflavones to more potent phytoestrogens.
KW - cytochrome P-450
KW - daidzein
KW - formononetin
KW - genistein
KW - in vitro
KW - isoflavones
KW - legumes
KW - liver
KW - metabolism
KW - microsomes
KW - plant oestrogens
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - 6,7-dihydroxy-4'-methoxyisoflavone
KW - 7,3'-dihydroxy-4'-methoxyisoflavone
KW - 7,8-dihydroxy-4'-methoxyisoflavone
KW - biochanin A
KW - phytoestrogens
KW - plant estrogens
KW - Crop Produce (QQ050)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053077627&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2002/50/i17/abs/jf025549r.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Digestibility of food allergens and nonallergenic proteins in simulated gastric fluid and simulated intestinal fluid - a comparative study.
AU - Fu, T. J.
AU - Abbott, U. R.
AU - Hatzos, C.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2002///
VL - 50
IS - 24
SP - 7154
EP - 7160
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Fu, T. J.: U.S. Food and Drug Administration and Illinois Institute of Technology, National Center for Food Safety and Technology, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063035728. Publication Type: Journal Article. Language: English.
N2 - Information on the comparative digestibility of food allergens and nonallergenic proteins is crucial when stability to digestion is to be used as a criterion to assess the allergenic potential of novel proteins. In this work, we compared the digestive stability of a number of food allergens and proteins of unproven allergenicity and examined whether allergens possess a higher stability than nonallergenic proteins of similar cellular functions, and whether there is a correlation between protein digestibility and allergenicity. The stability of groups of storage proteins, plant lectins, contractile proteins, and enzymes, both allergens and proteins with unproven allergenicity, in a standard simulated gastric fluid and a standard simulated intestinal fluid was measured. Food allergens were not necessarily more resistant to digestion than nonallergenic proteins. There was not a clear relationship between digestibility measured in vitro and protein allergenicity.
KW - allergens
KW - food allergies
KW - gastric juices
KW - intestines
KW - protein digestibility
KW - food hypersensitivity
KW - stomach secretion
KW - Food Chemistry (QQ600) (New June 2002)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063035728&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2002/50/i24/abs/jf020599h.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adult Blood Lead Epidemiology and Surveillance - United States, 1998-2001.
AU - Roscoe, R. J.
AU - Ball, W.
AU - Curran, J. J.
AU - DeLaurier, C.
AU - Falken, M. C.
AU - Fitchett, R.
AU - Fleissner, M. L.
AU - Fletcher, A. E.
AU - Garman, S. J.
AU - Gergely, R. M.
AU - Gerwel, B. T.
AU - Gostin, J. E.
AU - Keyvan-Larijani, E.
AU - Leiker, R. D.
AU - Lofgren, J. P.
AU - Nelson, D. R.
AU - Payne, S. F.
AU - Rabin, R. A.
AU - Salzman, D. L.
AU - Schaller, K. E.
AU - Sims, A. S.
AU - Smith, J. D.
AU - Socie, E. M.
AU - Stoeckel, M.
AU - Stone, R. R.
AU - Whittaker, S. G.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2002///
VL - 51
IS - SS-11
SP - 1
EP - 10
CY - Waltham; USA
PB - Massachusetts Medical Society
SN - 0149-2195
AD - Roscoe, R. J.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio, USA.
N1 - Accession Number: 20033016207. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - Problem/Condition: Elevated blood lead levels (BLLs) in adults can damage the cardiovascular, central nervous, reproductive, haematologic, and renal systems. The majority of cases are workplace-related. U.S. Department of Health and Human Services recommends that BLLs among all adults be reduced to <25 µg/dl. The highest BLL acceptable by standards of the U.S. Occupational Safety and Health Administration is 40 µg/dl. The mean BLL of adults in the USA is <3 µg/dl. Reporting Period: This report covers cases of adults (aged ≥16 years) with BLLs ≥25 µg/dl, as reported by 25 states during 1998-2001. Description of System: Since 1987, CDC has sponsored the state-based Adult Blood Lead Epidemiology and Surveillance (ABLES) programme to track cases of elevated BLLs and provide intervention consultation and other assistance. Overall ABLES programme data were last published in 1999 for the years 1994-1997. This report provides an update with data from 25 states reporting for ≥2 years during 1998-2001. During that period, the ABLES programme funded surveillance in 21 states - Alabama, Arizona, Connecticut, Iowa, Maryland, Massachusetts, Michigan, Minnesota, New Jersey, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Texas, Washington, Wisconsin, and Wyoming. Four additional states - California, Nebraska, New Hampshire, and Utah - contributed data without CDC funding. Results: During 1998-2001, the overall programme's annual mean state prevalence rate for adults with BLLs ≥25 µg/dl was 13.4/100 000 employed adults. This compares with 15.2/100 000 for 1994-1997. Yearly rates were 13.8 (1998), 12.9 (1999), 14.3 (2000), and 12.5 (2001). For adults with BLLs ≥40 µg/dl, the overall programme's annual mean state prevalence rate during 1998-2001 was 2.9/100 000 employed adults. This compares with 3.9/100 000 for 1994-1997. Yearly rates were 3.3 (1998), 2.5 (1999), 2.9 (2000), and 2.8 (2001). Interpretation: Although certain limitations exist, the overall ABLES data indicate a declining trend in elevated BLLs among employed adults. Public Health Actions: ABLES-funded states increased from 21 to 35 in 2002, and more detailed reporting requirements were put into effect. These, and other improvements, will enable the ABLES programme to work more effectively toward its 2010 target of eliminating all cases of BLLs ≥25 µg/dl in adults caused by workplace exposures.
KW - adults
KW - epidemiology
KW - lead
KW - lead poisoning
KW - surveys
KW - Alabama
KW - Arizona
KW - California
KW - Connecticut
KW - Iowa
KW - Maryland
KW - Massachusetts
KW - Michigan
KW - Minnesota
KW - Nebraska
KW - New Hampshire
KW - New Jersey
KW - New York
KW - North Carolina
KW - Ohio
KW - Oklahoma
KW - Oregon
KW - Pennsylvania
KW - Rhode Island
KW - South Carolina
KW - Texas
KW - USA
KW - Utah
KW - Washington
KW - Wisconsin
KW - Wyoming
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - Pacific States of USA
KW - New England States of USA
KW - Northeastern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - West North Central States of USA
KW - South Atlantic States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - Great Plains States of USA
KW - Northern Plains States of USA
KW - Middle Atlantic States of USA
KW - Appalachian States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Pacific Northwest States of USA
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033016207&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of case definitions for acute encephalopathy, encephalitis, and multiple sclerosis reports to the Vaccine Adverse Event Reporting System.
AU - Ball, R.
AU - Halsey, N.
AU - Braun, M. M.
AU - Moulton, L. H.
AU - Gale, A. D.
AU - Rammohan, K.
AU - Wiznitzer, M.
AU - Johnson, R.
AU - Salive, M. E.
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2002///
VL - 55
IS - 8
SP - 819
EP - 824
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0895-4356
AD - Ball, R.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-220, Rockville, MD 20852, USA.
N1 - Accession Number: 20023158323. Publication Type: Journal Article. Corporate Author: VAERS Working Group Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - The Vaccine Adverse Event Reporting System (VAERS), administered by the FDA and CDC, is the U.S. system for surveillance of vaccine adverse events (AE). Acute encephalopathy in age<18 months (EO<18) and in age ≥18 months (EO≥18), encephalitis (EI), and multiple sclerosis (MS) after vaccination have been reported to VAERS, but reports often contain insufficient information to validate diagnoses. Standardized case definitions would enhance the utility of VAERS reports for AE surveillance. We developed practical case definitions for classification of VAERS reports, and three neurologists independently applied the definitions to reports submitted in 1993. Inter-observer agreement was assessed, and non-concordant classifications were reviewed in a follow-up conference call. Reports of EO<18 (n=8), EO≥18 (n=20), EI (n=15), and MS (n=16) were classified as "definite" in 7% to 30% of the cases, while 26% to 51% of reports were thought to have insufficient information to make a classification. Agreement among reviewers was good to excellent, (kappa: 0.65 to 0.85) except for EO<18 months for which it was marginal (kappa: 0.37). It is possible to develop reproducible case definitions for acute encephalopathy, encephalitis, and multiple sclerosis using a standardized approach. Application of standardized case definitions to VAERS reports documents the limited information in many reports, specifies data for supplemental collection, and indicates that VAERS reports should be cautiously interpreted. Development and application of case definitions for other adverse events reported after vaccination should enhance the value of vaccine safety databases.
KW - adverse effects
KW - case definitions
KW - encephalitis
KW - encephalopathy
KW - human diseases
KW - immunization
KW - multiple sclerosis
KW - safety
KW - vaccination
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - clinical case definitions
KW - encephalomyelitis
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023158323&site=ehost-live&scope=site
UR - email: ballr@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parasites and the food supply.
AU - Orlandi, P. A.
AU - Chu, D. M. T.
AU - Bier, J. W.
AU - Jackson, G. J.
JO - Food Technology (Chicago)
JF - Food Technology (Chicago)
Y1 - 2002///
VL - 56
IS - 4
SP - 72
EP - 81
CY - Chicago; USA
PB - Institute of Food Technologists
SN - 0015-6639
AD - Orlandi, P. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20023110396. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health; Protozoology; Helminthology
N2 - This paper, based on the Scientific Status Summary prepared by the Institute of Food Technologists' Expert Panel on Food Safety and Nutrition, discusses the sources and incidence of human infections by foodborne parasites (i.e., protozoa and helminths) in the USA. The development of new technologies for their prevention, detection and control are also addressed.
KW - analytical methods
KW - disease control
KW - disease incidence
KW - disease prevention
KW - epidemiology
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - helminthoses
KW - helminths
KW - human diseases
KW - microbial contamination
KW - protozoal infections
KW - USA
KW - man
KW - Protozoa
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - food contaminants
KW - parasitic worms
KW - protozoal diseases
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023110396&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Persistent organic pollutants exposure assessment using the US Total Diet Study.
AU - Bolger, P. M.
AU - Egan, K.
AU - Jensen, E.
AU - Canady, R.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2002///
VL - 56
IS - 11
SP - 818
EP - 819
CY - London; UK
PB - BMJ Publishing Group
SN - 0143-005X
AD - Bolger, P. M.: Division of Risk Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20023166764. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Human Nutrition; Soils & Fertilizers
KW - exposure
KW - food contamination
KW - foods
KW - methodology
KW - pollutants
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023166764&site=ehost-live&scope=site
UR - email: Philip.Bolger@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation of dietary supplements: FDA's strategic plan.
AU - Levitt, J. A.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 2002///
VL - 57
IS - 1
SP - 1
EP - 13
CY - Washington; USA
PB - Food and Drug Law Institute
SN - 1064-590X
AD - Levitt, J. A.: Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration (FDA), 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20033024217. Publication Type: Journal Article. Language: English. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - This article highlights critical issues stakeholders view as priorites in implementing the Dietary Supplement Strategic Plan (DSSP) developed by the Food and Drug Administration (FDA; USA) in achieving the objectives of the Dietary Supplement Health and Education Act of 1994. The mechanism used by the FDA in developing the DSSP and the basic parameters of the DSSP are discussed, and the state of the implementation efforts are summarized.
KW - consumer protection
KW - food legislation
KW - food policy
KW - food supplements
KW - functional foods
KW - regulations
KW - standards
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Consumer Economics (EE720)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033024217&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival characteristics and age-adjusted disease incidences in C57BL/6 mice fed a commonly used cereal-based diet modulated by dietary restriction.
AU - Turturro, A.
AU - Duffy, P.
AU - Hass, B.
AU - Kodell, R.
AU - Hart, R.
JO - Journal of Gerontology. Series A, Biological Sciences and Medical Sciences
JF - Journal of Gerontology. Series A, Biological Sciences and Medical Sciences
Y1 - 2002///
VL - 57
IS - 11
SP - B379
EP - B389
CY - Washington; USA
PB - Gerontological Society of America
SN - 1079-5006
AD - Turturro, A.: Division of Biometry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033027257. Publication Type: Journal Article. Language: English. Subject Subsets: Dairy Science; Human Nutrition
N2 - Studies of C57BL/6 mice are often restricted to one sex, with limited characterization of pathology as a function of age. As part of the National Institute on Aging/National Center for Toxicological Research Collaboration on Biomarkers, over 3000 males and 1500 females of this strain were raised, maintained, and used to evaluate longevity under specific pathogen-free conditions. A diet commonly used in testing the impact of agents was fed ad libitum or was restricted to 60% of normal consumption, starting when the mice were 14-16 weeks of age. Cardiac, renal, and central nervous system pathologies were significantly inhibited by dietary restriction (DR), as were bone degeneration, inflammation, hyperplasia, amyloid induction, and atrophy of secretory organs. Hematological disorders and tumors were among the most common problem in this strain, and they were ameliorated by DR. In males, for other neoplasms, adrenal adenomas, liver tumors, and hemangiomas combined with hemangiosarcomas were decreased by DR, variably in onset and progression. In females, DR decreased pituitary tumors, mammary tumors, and alveolar carcinomas, again variably in onset and progression.
KW - adrenal glands
KW - animal models
KW - diet
KW - disease incidence
KW - epidemiology
KW - female animals
KW - food restriction
KW - laboratory animals
KW - liver
KW - male animals
KW - mammary glands
KW - neoplasms
KW - pituitary
KW - survival
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adrenals
KW - cancers
KW - hypophysis
KW - pituitary gland
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033027257&site=ehost-live&scope=site
UR - http://biomed.gerontologyjournals.org/cgi/content/abstract/57/11/B379
UR - email: Aturturro@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of unique microbial volatile organic compounds produced by five Aspergillus species commonly found in problem buildings.
AU - Gao, P. F.
AU - Korley, F.
AU - Martin, J.
AU - Chen, B. T.
JO - American Industrial Hygiene Association Journal
JF - American Industrial Hygiene Association Journal
Y1 - 2002///
VL - 63
IS - 2
SP - 135
EP - 140
CY - Fairfax; USA
PB - American Industrial Hygiene Association
SN - 1529-8663
AD - Gao, P. F.: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023063435. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - This study identified unique microbial volatile organic compounds (UMVOCs) produced by five Aspergillus species (A. fumigatus, A. versicolor, A. sydowii, A. flavus, and A. niger) cultivated on malt extract agar and gypsum board. The hypothesis was that UMVOCs can be used to predict the presence of Aspergillus species. During the cultivation humidified air was continually supplied and evenly distributed through each of the culture flasks. Volatile metabolites were collected using Tenax TA tubes on Days 8, 16, and 30 after inoculation. The volatile metabolites were determined by gas chromatography/mass spectroscopy after thermal desorption. Nine compounds recognized as UMVOCs - 3-methyl-1-butanol; 2-methyl-1-propanol; terpineol; 2-heptanone; 1-octen-3-ol; dimethyl disulfide; 2-hexanone; 3-octanone; and 2-pentylfuran - were found on the cultures in detectable amounts. The first two compounds were detected at the highest frequency when combining both media. The first four compounds were found to be the dominant UMVOCs on gypsum board, which could be used as chemical markers of the common Aspergillus species grown indoors.
KW - analytical methods
KW - gypsum blocks
KW - markers
KW - organic compounds
KW - volatile compounds
KW - Aspergillus flavus
KW - Aspergillus fumigatus
KW - Aspergillus niger
KW - Aspergillus sydowii
KW - Aspergillus versicolor
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - analytical techniques
KW - fungus
KW - Hyphomycetes
KW - organic chemicals
KW - volatile constituents
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063435&site=ehost-live&scope=site
UR - email: Pgao@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.
AU - Calvert, R. J.
AU - Ramakrishna, G.
AU - Tepper, S.
AU - Diwan, B. A.
AU - Anderson, L. M.
AU - Kritchevsky, D.
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2002///
VL - 64
IS - 1
SP - 41
EP - 48
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0006-2952
AD - Calvert, R. J.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20023120675. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 11041-12-6, 59-67-6.
KW - animal models
KW - colestyramine
KW - laboratory animals
KW - lungs
KW - nicotinic acid
KW - proteins
KW - surface proteins
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cholestyramine
KW - lovastatin
KW - membrane proteins
KW - niacin
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023120675&site=ehost-live&scope=site
UR - email: calvert@mail.ncifcrf.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vibrio vulnificus and Vibrio parahaemolyticus in U.S. retail shell oysters: a national survey from June 1998 to July 1999.
AU - Cook, D. W.
AU - O'Leary, P.
AU - Hunsucker, J. C.
AU - Sloan, E. M.
AU - Bowers, J. C.
AU - Blodgett, R. J.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 1
SP - 79
EP - 87
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cook, D. W.: Gulf Coast Seafood Laboratory, Food and Drug Administration, Iberville Drive, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20023009717. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health; Human Nutrition; Veterinary Science; Veterinary Science
N2 - From June 1998 to July 1999, 370 lots of oysters in the shell were sampled at 275 different establishments (71%, restaurants or oyster bars; 27%, retail seafood markets; and 2%, wholesale seafood markets) in coastal and inland markets throughout the United States. The oysters were harvested from the Gulf (49%), Pacific (14%), Mid-Atlantic (18%), and North Atlantic (11%) Coasts of the United States and from Canada (8%). Samples were collected by state health public agencies as follows: 39 in Washington, 39 in California, 46 in Colorado, 45 in Illinois, 46 in Louisiana, 42 in Alabama, 40 in Florida, 31 in Maryland and 42 in Massachusetts. Densities of Vibrio vulnificus and Vibrio parahaemolyticus were determined using a modification of the most probable number (MPN) techniques described in the Food and Drug Administration's Bacteriological Analytical Manual. DNA probes and enzyme immunoassay were used to identify suspect isolates and to determine the presence of the thermostable direct haemolysin gene associated with pathogenicity of V. parahaemolyticus. Densities of both V. vulnificus and V. parahaemolyticus in market oysters from all harvest regions followed a seasonal distribution, with highest densities in the summer. Highest densities of both organisms were observed in oysters harvested from the Gulf Coast, where densities often exceeded 10 000 MPN/g. The majority (78%) of lots harvested in the North Atlantic, Pacific, and Canadian Coasts had V. vulnificus densities below the detectable level of 0.2 MPN/g; none exceeded 100 MPN/g. V. parahaemolyticus densities were greater than those of V. vulnificus in lots from these same areas, with some lots exceeding 1000 MPN/g for V. parahaemolyticus. Some lots from the Mid-Atlantic states exceeded 10 000 MPN/g for both V. vulnificus and V. parahaemolyticus. Overall, there was a significant correlation between V. vulnificus and V. parahaemolyticus densities (r=0.72, n=202, P<0.0001), but neither density correlated with salinity. Storage time significantly affected the V. vulnificus (10% decrease per day) and V. parahaemolyticus (7% decrease per day) densities in market oysters. The thermostable direct haemolysin gene associated with V. parahaemolyticus virulence was detected in 9 of 3429 (0.3%) V. parahaemolyticus cultures and in 8 of 198 (4.0%) lots of oysters. These data can be used to estimate the exposure of raw oyster consumers to V. vulnificus and V. parahaemolyticus.
KW - disease prevalence
KW - disease surveys
KW - oysters
KW - seasonal variation
KW - storage
KW - Alabama
KW - California
KW - Canada
KW - Colorado
KW - Florida
KW - Illinois
KW - Louisiana
KW - Maryland
KW - Massachusetts
KW - USA
KW - Washington
KW - Crassostrea gigas
KW - Crassostrea virginica
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Crassostrea
KW - Ostreidae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - Commonwealth of Nations
KW - Great Plains States of USA
KW - Mountain States of USA
KW - South Atlantic States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - Delta States of USA
KW - West South Central States of USA
KW - New England States of USA
KW - Northeastern States of USA
KW - Pacific Northwest States of USA
KW - bacterium
KW - disease surveillance
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023009717&site=ehost-live&scope=site
UR - email: adepaola@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A polymerase chain reaction-based method for the detection of hepatitis A virus in produce and shellfish.
AU - Goswami, B. B.
AU - Kulka, M.
AU - Ngo, D.
AU - Istafanos, P.
AU - Cebula, T. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 2
SP - 393
EP - 402
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Goswami, B. B.: Division of Molecular Biological Research and Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-237, 200 C Street S.W., Washington, DC 20204, USA.
N1 - Accession Number: 20023028424. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 63231-63-0. Subject Subsets: Public Health; Aromatic & Medicinal Plants; Animal Breeding
N2 - Outbreaks of gastroenteritis that are suspected to be of viral origin are on the rise. Thus, there is a need for regulatory agencies entrusted with food safety to develop adequate techniques for the detection of viruses in foods. We have established a general procedure for the detection of hepatitis A virus (HAV) in shellfish that, with minor modifications, is also applicable to fresh produce such as cilantro [Coriandrum sativum]. Total RNA was isolated from shellfish or cilantro, followed by isolation of poly(A)-containing RNA. Because HAV genomic RNA contains a poly(A) tail, the isolation of poly(A)-containing RNA also enriches HAV genomic RNA. Reverse transcription was used to convert the RNA to cDNA, and then amplification was carried out by polymerase chain reaction (PCR). Reamplification with internal primers was used to improve the quality and the quantity of amplified DNA, allowing for post-PCR analysis such as sequence identification of the viral strain. With this procedure, multiple samples could be analysed in 4 working days by a single trained individual. The nominal sensitivity of detection of the procedure was 0.15 TCID50 (50% tissue culture infective dose) per 0.62 g of tissue with a test virus. The direct RNA isolation protocol avoided pitfalls associated with whole-virus purification procedures by replacing virus precipitation steps involving polyethylene glycol and Procipitate with phenol extraction. The method is straightforward and reliable. We successfully used this procedure to detect naturally occurring HAV in clams (Ruditapes philippinarum) involved in a gastroenteritis outbreak in New York (USA), as well as in cilantro which was artificially contaminated with a test virus.
KW - analytical methods
KW - clams
KW - detection
KW - food contamination
KW - food safety
KW - gastroenteritis
KW - hepatitis A
KW - human diseases
KW - microbial contamination
KW - outbreaks
KW - polymerase chain reaction
KW - RNA
KW - shellfish
KW - New York
KW - USA
KW - Coriandrum sativum
KW - hepatitis A virus
KW - man
KW - Veneridae
KW - Venerupis philippinarum
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Coriandrum
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Veneridae
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Venerupis
KW - analytical techniques
KW - Araliales
KW - coriander
KW - food contaminants
KW - PCR
KW - ribonucleic acid
KW - Ruditapes
KW - Ruditapes philippinarum
KW - United States of America
KW - Aquaculture (Animals) (MM120)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023028424&site=ehost-live&scope=site
UR - email: bgoswami@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of flour and food samples for cry9C from bioengineered corn.
AU - Orlandi, P. A.
AU - Lampel, K. A.
AU - South, P. K.
AU - Assar, S. K.
AU - Carter, L.
AU - Levy, D. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 2
SP - 426
EP - 431
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Orlandi, P. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-237, 200 C Street S.W., Washington, DC 20204, USA.
N1 - Accession Number: 20023028433. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Plant Breeding; Human Nutrition; Maize; Agricultural Biotechnology; Postharvest Research
N2 - StarLink corn is a variety of yellow corn that has been genetically modified by the insertion of an altered cry9C gene into the plant genome, resulting in expression of the insecticidal Cry9C protein. The U.S. Environmental Protection Agency has approved StarLink corn for use in animal feed but not in food intended for human consumption. Therefore, under the U.S. Food, Drug, and Cosmetic Act, any food intended for human consumption in which the presence of StarLink corn is indicated by the presence of either the Cry9C protein or the cry9C gene would be considered adulterated. Extraction and PCR-based methods were used to detect the presence of the cry9C DNA initially in corn flour and corn meal, and then these methods were extended to the analysis of processed corn products, including taco shells, cereals, baby foods, party snacks, and chips, for the presence of this modified genetic material. In a survey of 63 products, the cry9C transgene was detected in 4 taco shells.
KW - adulteration
KW - consumer protection
KW - corn flour
KW - food inspection
KW - genetically engineered organisms
KW - maize
KW - quality controls
KW - transgenic plants
KW - plants
KW - Zea mays
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - consumer advocacy
KW - corn
KW - cornflour
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - maize flour
KW - quality assurance
KW - Laws and Regulations (DD500)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023028433&site=ehost-live&scope=site
UR - email: dlevy@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance of food-related Salmonella isolates, 1999-2000.
AU - Kiessling, C. R.
AU - Cutting, J. H.
AU - Loftis, M.
AU - Kiessling, W. M.
AU - Datta, A. R.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 4
SP - 603
EP - 608
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Kiessling, C. R.: Denver District Laboratory, Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20023063339. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 56-75-7, 85721-33-1, 1403-66-3, 1405-41-0, 389-08-2, 70458-96-7, 13292-46-1, 57-92-1, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Veterinary Science; Veterinary Science; Public Health
N2 - Salmonellosis is a major foodborne infection in USA, and strains of Salmonella that are resistant to a variety of antimicrobial agents have become a major public health concern. To estimate the incidence of antimicrobial-resistant Salmonella in our food supply, the U.S. Food and Drug Administration (FDA) has initiated screening of foodborne isolates for sensitivity to antimicrobial agents, including several antibiotics. Salmonella cultures (n=502) isolated by FDA laboratories during fiscal year 2000 (1 October 1999 through 30 September 2000) from domestic and imported food products and related samples were tested for susceptibility to each of 12 antimicrobial agents using a disc diffusion assay. Because all isolates were resistant to rifampicin (5 or 25 µg), only results with the remaining 11 antimicrobial agents (ampicillin, chloramphenicol, ciprofloxacin, gentamicin, nalidixic acid, sulfisoxazole, streptomycin, sulfamethoxazole/trimethoprim, tetracycline, trimethoprim and norfloxacin) are discussed in this paper. Of the 502 isolates, 247 (49.2%) were resistant to one or more antimicrobial agents, and of these 247 isolates, 170 (68.8%) were resistant to one antimicrobial agent, 33 (13.4%) to two antimicrobial agents, 25 (10.1%) to three antimicrobial agents, 7 (2.8%) to four antimicrobial agents, 8 (3.2%) to five antimicrobial agents, and 2 (0.8%) each to six and seven antimicrobial agents. No isolates were resistant to norfloxacin, whereas only seven were resistant to sulfamethoxazole/trimethoprim, six to trimethoprim, three to gentamicin, and one to ciprofloxacin. These results, for the first time, provide a baseline of data on the incidence of antimicrobial-resistant Salmonella in the U.S. food supply, which should be useful in determining the evolution of antimicrobial resistance in the future.
KW - ampicillin
KW - antibacterial agents
KW - chloramphenicol
KW - ciprofloxacin
KW - epidemiology
KW - food contamination
KW - food products
KW - foodborne diseases
KW - gentamicin
KW - human diseases
KW - multiple drug resistance
KW - nalidixic acid
KW - norfloxacin
KW - rifampicin
KW - salmonellosis
KW - streptomycin
KW - sulfamethoxazole
KW - tetracycline
KW - trimethoprim
KW - USA
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - bacterium
KW - food contaminants
KW - rifampin
KW - rifamycin amp
KW - Salmonella infections
KW - sulfisoxazole
KW - sulphamethoxazole
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063339&site=ehost-live&scope=site
UR - email: ckiessli@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbial evaluation of selected fresh produce obtained at retail markets.
AU - Thunberg, R. L.
AU - Tran, T. T.
AU - Bennett, R. W.
AU - Matthews, R. N.
AU - Belay, N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 4
SP - 677
EP - 682
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Thunberg, R. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
N1 - Accession Number: 20023063350. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Human Nutrition; Public Health
N2 - The microbial quality of five types of fresh produce obtained at the retail level (a market in District of Columbia, USA) [date not given] was determined by standard quantitative techniques. These techniques included aerobic plate count (APC), total coliform counts, Escherichia coli counts, and yeast and mould counts. Three different methods were used to determine total coliform counts, which consisted of MacConkey agar plate counts, Colicomplete most probable number counts, and Petrifilm E. coli (EC) plate counts. The mean APCs for sprouts, lettuce, celery, cauliflower, and broccoli were 8.7, 8.6, 7.5, 7.4, and 6.3 log10 CFU/g, respectively. MacConkey agar counts indicated that 89 to 96% of the APCs consisted of gram-negative bacteria. Yeast and mold counts were in a range expected of fresh produce. Fresh produce was also analysed for human pathogens. Samples were analysed for Staphylococcus spp., Bacillus spp., Salmonella spp., Listeria spp., and Campylobacter spp. One isolate of Staphylococcus was found to be enterotoxigenic, and one species of Bacillus was also toxigenic. Neither Salmonella spp. nor Campylobacter spp. were detected in any of the produce samples. A variety of Listeria spp., including Listeria monocytogenes, were found in fresh produce.
KW - bacterial diseases
KW - broccoli
KW - cauliflowers
KW - celery
KW - coliform bacteria
KW - food contamination
KW - foodborne diseases
KW - fresh products
KW - human diseases
KW - lettuces
KW - microbial contamination
KW - sprouts
KW - vegetables
KW - District of Columbia
KW - USA
KW - Apium graveolens
KW - Brassica oleracea
KW - Brassica oleracea var. botrytis
KW - Campylobacter
KW - Escherichia coli
KW - Lactuca sativa
KW - Listeria
KW - Listeria monocytogenes
KW - man
KW - Salmonella
KW - Staphylococcus
KW - Apium
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - Brassica oleracea
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Listeria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Staphylococcaceae
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Araliales
KW - Bacillus
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - calabrese
KW - Capparales
KW - E. coli
KW - food contaminants
KW - heading broccoli
KW - United States of America
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023063350&site=ehost-live&scope=site
UR - email: richard.thunberg@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of low-dose gamma irradiation on Staphylococcus aureus and product packaging in ready-to-eat ham and cheese sandwiches.
AU - Lamb, J. L.
AU - Gogley, J. M.
AU - Thompson, M. J.
AU - Solis, D. R.
AU - Sen, S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 11
SP - 1800
EP - 1805
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Lamb, J. L.: Microbiology Branch, U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Los Angeles, CA 90015, USA.
N1 - Accession Number: 20023189532. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Pig Science; Dairy Science
N2 - Staphylococcus aureus is a common pathogen that causes foodborne illness. Traditional methods for controlling S. aureus do not address postprocess contamination. Low-dose gamma irradiation is effective in reducing pathogens in a variety of foods and may be effective in reducing S. aureus in ready-to-eat foods. The effects of gamma irradiation on product packaging should also be considered. The objective of this study was to determine the effects of gamma irradiation on product packaging and on S. aureus in ready-to-eat ham and cheese sandwiches. The effects of refrigerated storage on irradiated and nonirradiated sandwiches were also investigated. Ham and cheese sandwiches were inoculated with 106 or 107 CFU of S. aureus per gram, frozen, irradiated, and analysed by a standard plate count method. D10-values, the amount of irradiation needed to elicit a 1-log10 reduction of bacteria, were calculated. In addition, irradiated sandwiches were analysed after 1, 13, 27, and 39 days of storage at 4°C. The integrity of postirradiated packaging material was analysed using Fourier transform infrared (FTIR) spectroscopy. Two experiments yielded D10-values of 0.62 and 0.63. During refrigerated storage, sandwiches irradiated with 5.9 kGy showed no S. aureus growth at any time; sandwiches irradiated with 3.85 kGy showed a 6.18-log reduction in S. aureus after 13 days; and nonirradiated sandwiches showed a 0.53-log increase in S. aureus after 39 days. FTIR spectroscopy showed that the label side and the bulge side were composed of polyethylene terephthalate and nylon 6, respectively. No significant change in the packaging due to irradiation was detected. In this study, low-dose gamma irradiation was shown to be an effective method for reducing S. aureus in ready-to-eat ham and cheese sandwiches and proved to be more efficacious than refrigeration alone. Additionally, package integrity was not adversely affected by gamma irradiation.
KW - cheeses
KW - convenience foods
KW - food contamination
KW - food irradiation
KW - food packaging
KW - food safety
KW - gamma radiation
KW - ham
KW - microbial contamination
KW - packaging materials
KW - pathogens
KW - refrigeration
KW - sandwiches
KW - Staphylococcus aureus
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - gamma rays
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023189532&site=ehost-live&scope=site
UR - email: jlamb@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Density of total and pathogenic (tdh+) Vibrio parahaemolyticus in Atlantic and Gulf Coast molluscan shellfish at harvest.
AU - Cook, D. W.
AU - Bowers, J. C.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2002///
VL - 65
IS - 12
SP - 1873
EP - 1880
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cook, D. W.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, One Iberville Drive, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033002912. Publication Type: Journal Article. Language: English. Number of References: 18 ref.
N2 - The densities of total and pathogenic Vibrio parahaemolyticus in 671 samples of molluscan shellfish harvested in 1999 and 2000 from 14 sites in 7 Gulf and Atlantic coast states (New York, Connecticut, Texas, Virginia, Louisiana, Massachusetts, Alabama) were determined at 2-week intervals over a period of 12 to 16 months in each state. Changes in V. parahaemolyticus densities in shellfish between harvest and sample analysis were minimized with time and temperature controls. Densities were measured by direct plating techniques, and gene probes were used for identification. Total and pathogenic V. parahaemolyticus organisms were identified with probes for the thermolabile direct haemolysin (tlh) gene and the thermostable direct haemolysin (tdh) gene, respectively. An enrichment procedure involving 25 g of shellfish was also used for the recovery of pathogenic V. parahaemolyticus. The densities of V. parahaemolyticus in shellfish from all harvest sites were positively correlated with water temperature. Shellfish from the Gulf Coast typically had higher densities of V. parahaemolyticus than did shellfish harvested from the North Atlantic or mid-Atlantic coast. Vibrio parahaemolyticus counts exceeded 1000 CFU/g for only 5% of all samples. Pathogenic (tdh+) V. parahaemolyticus was detected in approximately 6% of all samples by both procedures, and 61.5% of populations in the positive samples from the direct plating procedure were at the lower limit of detection (10 CFU/g). The frequency of detection of pathogenic V. parahaemolyticus was significantly related to water temperature and to the density of total V. parahaemolyticus. The failure to detect pathogenic V. parahaemolyticus in shellfish was more frequently attributed to the low numbers and uneven distribution of the organism.
KW - density
KW - food contamination
KW - harvesting date
KW - microbial contamination
KW - pathogens
KW - salinity
KW - shellfish
KW - water temperature
KW - Alabama
KW - Connecticut
KW - Louisiana
KW - Massachusetts
KW - New York
KW - Texas
KW - USA
KW - Virginia
KW - bacteria
KW - Mollusca
KW - Vibrio parahaemolyticus
KW - prokaryotes
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - New England States of USA
KW - Northeastern States of USA
KW - Delta States of USA
KW - West South Central States of USA
KW - Middle Atlantic States of USA
KW - Great Plains States of USA
KW - Southern Plains States of USA
KW - Southwestern States of USA
KW - Appalachian States of USA
KW - South Atlantic States of USA
KW - bacterium
KW - food contaminants
KW - harvest date
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033002912&site=ehost-live&scope=site
UR - email: dcook@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Outbreak of tick-borne relapsing fever at the North Rim of the Grand Canyon: evidence for effectiveness of preventive measures.
AU - Paul, W. S.
AU - Maupin, G.
AU - Scott-Wright, A. O.
AU - Craven, R. B.
AU - Dennis, D. T.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2002///
VL - 66
IS - 1
SP - 71
EP - 75
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Paul, W. S.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers For Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20023126528. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - An outbreak of tickborne relapsing fever (TBRF; caused by Borrelia hermsii) originating at the North Rim of Grand Canyon National Park, Arizona, USA, was investigated in 1990. To determine the risk factors for the disease, almost 7000 parties of visitors were surveyed; over half responded, representing >10 000 people. 15 cases of confirmed or probable TBRF were identified in visitors and 2 in employees. All patients except one experienced symptoms after overnight stays in a group of cabins that had not been rodent-proofed after a TBRF outbreak in 1973 (relative risk for visitors (RR), 8.2; 95% confidence interval (CI): 1.1-62). Seven cases of TBRF were associated with a single cabin (RR, 98; 95% CI: 30-219). Structural flaws and rodent nests were common in the implicated cabins and rare in unaffected cabins. This investigation suggests that measures to rodent-proof cabins at sites where TBRF is endemic prevent reinfestation of cabins by infected rodents and tick vectors, thereby preventing the spread of disease in humans.
KW - human diseases
KW - national parks
KW - nests
KW - outbreaks
KW - personnel
KW - risk factors
KW - tickborne diseases
KW - tickborne relapsing fever
KW - visitors
KW - Arizona
KW - USA
KW - Borrelia hermsii
KW - man
KW - rodents
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - bacterium
KW - employees
KW - guests
KW - staff
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023126528&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hantavirus pulmonary syndrome: a zebra worth knowing.
AU - Graziano, K. L.
AU - Tempest, B.
JO - American Family Physician
JF - American Family Physician
Y1 - 2002///
VL - 66
IS - 6
SP - 1015
EP - 1020
CY - Leawood; USA
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Graziano, K. L.: Tuba City Indian Medical Center, Navajo Area Indian Health Service, P.O. Box 600, Tuba City, AZ 86045, USA.
N1 - Accession Number: 20023174939. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - Hantavirus pulmonary syndrome (HPS) is a severe cardiopulmonary illness most often caused by the Sin Nombre virus, which is transmitted to humans by inhalation of aerosolized particles of rodent excreta or direct rodent contact. Although HPS is more common in the western United States, cases have been identified in 31 states. The illness begins as a nonspecific febrile prodrome, sharing many of its initial symptoms with other more common viral infections. Patients then quickly develop noncardiogenic pulmonary edema, respiratory failure, and shock. Characteristic laboratory findings include thrombocytopenia, a left-shifted leukocytosis, hemoconcentration, and presence of immunoblasts. The overall case fatality rate of HPS is approximately 40 percent. Diagnosis is confirmed by serologic identification of IgM and IgG antibodies to Sin Nombre virus. There is no specific therapy, but early recognition of HPS during the prodromal phase can expedite initiating cardiopulmonary support in an intensive care unit, which is associated with improved survival rates. Prevention of HPS involves avoiding contact with rodents and rodent habitats.
KW - clinical aspects
KW - diagnosis
KW - disease prevention
KW - epidemiology
KW - hantavirus pulmonary syndrome
KW - human diseases
KW - IgG
KW - IgM
KW - intensive care
KW - laboratory diagnosis
KW - lungs
KW - mortality
KW - oedema
KW - respiratory diseases
KW - reviews
KW - survival
KW - therapy
KW - thrombocytopenia
KW - viral diseases
KW - zoonoses
KW - USA
KW - Hantavirus
KW - man
KW - Sin Nombre virus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hantavirus
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - clinical picture
KW - critical care
KW - death rate
KW - edema
KW - leukocytosis
KW - lung diseases
KW - therapeutics
KW - United States of America
KW - viral infections
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023174939&site=ehost-live&scope=site
UR - http://www.aafp.org/afp/20020915/1015.html
UR - email: docgratz@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Drift in the hypervariable region of the hepatitis C virus during 27 years in two patients.
AU - Gao, G.
AU - Buskell, Z.
AU - Seeff, L.
AU - Tabor, E.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2002///
VL - 68
IS - 1
SP - 60
EP - 67
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Gao, G.: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20852-1448, USA.
N1 - Accession Number: 20023125639. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - Serial serum samples were obtained over a 27-year period from a hepatitis C virus (HCV)-infected patient who received transfusions of red blood cells and platelets between June 1972 and January 1973 and from a nurse who was infected by this patient during 12 March 1973 [USA]. The hypervariable region 1 (HVR1) and 5′noncoding region (5′NCR) of the HCV genome were amplified from each serum sample by polymerase chain reaction (PCR) and cloned. In the first serum specimen from the patient and the first two serum specimens from the nurse, most of the 20 clones from each serum sample had one common sequence in the HVR1 gene. All later serum samples contained a heterogeneous mixture of HCV quasispecies. The uniformity of the HVR1 sequence in the early samples and the emergence of greater diversity in later serum samples is consistent with the apparent transmission of HCV between the patient and nurse and the eventual emergence of other quasispecies as the virus replicated in the new host. In addition, the immune globulin given to the nurse may have been responsible for some of the HCV quasispecies changes observed in her serum.
KW - blood serum
KW - genes
KW - hepatitis C
KW - human diseases
KW - nucleotide sequences
KW - nurses
KW - USA
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - DNA sequences
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023125639&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology of human calicivirus gastroenteritis outbreaks in Hungary, 1998 to 2000.
AU - Reuter, G.
AU - Farkas, T.
AU - Berke, T.
AU - Jiang, X.
AU - Matson, D. O.
AU - Szücs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2002///
VL - 68
IS - 3
SP - 390
EP - 398
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Reuter, G.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság u. 7., Pécs, H-7623, Hungary.
N1 - Accession Number: 20023157638. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - Between November 1998 and November 2000, 196 faecal specimens from 21 outbreaks of acute nonbacterial gastroenteritis occurring in 11 of the 19 counties of Hungary, were collected and tested for human caliciviruses. Human caliciviruses were detected and characterized by a type-common enzyme-linked immunosorbent assay (EIA) and reverse transcription-polymerase chain reaction (RT-PCR) followed by cloning and sequencing. 20 (95%) and 14 (67%) outbreaks were positive by EIA and RT-PCR, respectively, and 12 RT-PCR-positive outbreaks were also confirmed by sequencing. Comparative sequence analysis revealed 13 Norwalk-like virus sequences in the 12 outbreaks, including 11 Norwalk-like virus genogroup II (7 in Hawaii-like, 2 Lordsdale-like, one Melksham-like and one Hillingdon-like) and 2 Norwalk-like virus genogroup I (related to Southampton-like and Desert Shield-like clusters) viruses. Multiple Norwalk-like virus clusters, with a predominance of Hawaii-like viruses, played an important role in nonbacterial gastroenteritis outbreaks during the study period. This is the first countrywide molecular epidemiological investigation of human calicivirus-associated gastroenteritis outbreaks in Hungary and Central-Eastern Europe.
KW - gastroenteritis
KW - genotypes
KW - human diseases
KW - molecular epidemiology
KW - molecular genetics
KW - nucleotide sequences
KW - outbreaks
KW - viral diseases
KW - Hungary
KW - Caliciviridae
KW - man
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Norovirus
KW - Caliciviridae
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - Desert Shield-like virus
KW - DNA sequences
KW - Hawaii-like virus
KW - Hillingdon-like virus
KW - Lordsdale-like virus
KW - Melksham-like virus
KW - Norwalk-like virus
KW - Southampton-like virus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157638&site=ehost-live&scope=site
UR - email: gszucs@main.antszbar.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inactivation of Cryptosporidium parvum oocysts in fresh apple cider by UV irradiation.
AU - Hanes, D. E.
AU - Worobo, R. W.
AU - Orlandi, P. A.
AU - Burr, D. H.
AU - Miliotis, M. D.
AU - Robl, M. G.
AU - Bier, J. W.
AU - Arrowood, M. J.
AU - Churey, J. J.
AU - Jackson, G. J.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2002///
VL - 68
IS - 8
SP - 4168
EP - 4172
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Hanes, D. E.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20023130404. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Protozoology
N2 - This study evaluated the efficacy of UV irradiation on the inactivation of Cryptosporidium parvum oocysts in fresh apple cider. Cider was inoculated with oocysts and exposed to 14.32 mJ of UV irradiation/cm2. Oocyst viability was assessed with the gamma interferon gene knockout (GKO) mouse and infant BALB/cByJ mouse models. All GKO mice challenged with UV-treated cider demonstrated no morbidity or mortality, and infant BALB/c mice challenged with treated cider were negative for the presence of C. parvum. In contrast, the GKO mice challenged with non-UV-treated inoculated cider died and the parasite was detected in the ileums of all challenged infant mice. This study shows that UV irradiation can be used to inactivate C. parvum in fresh apple cider.
KW - animal models
KW - apples
KW - cider
KW - inactivation
KW - irradiation
KW - oocysts
KW - parasites
KW - ultraviolet radiation
KW - Cryptosporidium parvum
KW - Malus
KW - mice
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - Other Control Measures (HH700)
KW - Crop Produce (QQ050)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023130404&site=ehost-live&scope=site
UR - email: dhanes@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical and immune impact of Mycobacterium bovis BCG vaccination scarring.
AU - Jason, J.
AU - Archibald, L. K.
AU - Nwanyanwu, O. C.
AU - Kazembe, P. N.
AU - Chatt, J. A.
AU - Norton, E.
AU - Dobbie, H.
AU - Jarvis, W. R.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2002///
VL - 70
IS - 11
SP - 6188
EP - 6195
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Jason, J.: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, U. S. Public Health Service, Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023169999. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 207137-56-2, 308079-78-9. Subject Subsets: Tropical Diseases
N2 - The World Health Organization recommends Mycobacterium bovis BCG vaccination in areas of high tuberculosis prevalence. BCG's clinical and immune effects, not necessarily Mycobacterium tuberculosis specific, are unclear. BCG vaccine scarring often is used as a surrogate marker of vaccination or of effective vaccination. We evaluated BCG scarring status in relation to clinical findings and outcome in 700 hospitalized Malawians admitted to the Lilongwe Central Hospital during 1997-98, of whom 32 had M. tuberculosis bloodstream infections (BSI) (10 of whom had cellular immune studies done) and of whom 48 were infants <6 months old and therefore recently vaccinated (19 of whom had immune studies). In the patients ≥6 months old, scarring was not related to the presence of pulmonary symptoms (35 vs. 30%), chronic cough or fever, mortality, or M. tuberculosis BSI. In M. tuberculosis BSI patients, scarring was unrelated to mortality, vital signs, or clinical symptoms but those with scarring had higher proportions of memory and activated T cells and more type 2-skewed cytokine profiles. Infants with either BCG scarring (n=10) or BCG lesional inflammation (n=5) had no symptoms of sepsis, but 18 of 33 infants without BCG vaccination lesions did. Those with BCG lesions had localized infections more often than did those without BCG lesions. These infants also had lower median percentages of lymphocytes spontaneously making interleukin-4 (IL-4) or tumour necrosis factor alpha (TNF-α) and lower ratios of T cells spontaneously making IL-4 to T cells making IL-6. Thus, we found that, in older patients, BCG vaccine scarring was not associated with M. tuberculosis-specific or nonspecific clinical protection. Those with M. tuberculosis BSI and scarring had immune findings suggesting previous M. tuberculosis antigen exposure and induction of a type 2 cytokine pattern with acute reexposure. It is unlikely that this type 2 pattern would be protective against mycobacteria, which require a type 1 response for effective containment. In infants <6 months old, recent BCG vaccination was associated with a non-M. tuberculosis-specific, anti-inflammatory cytokine profile. That the vaccinated infants had a greater frequency of localized infections and lesser frequency of sepsis symptoms suggests that this postvaccination cytokine pattern may provide some non-M. tuberculosis-specific clinical benefits.
KW - antigens
KW - BCG vaccine
KW - bloodstream infections
KW - cytokines
KW - disease prevalence
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - immunity
KW - immunization
KW - infants
KW - interleukin 4
KW - interleukin 6
KW - interleukins
KW - lymphocytes
KW - scars
KW - sepsis
KW - T lymphocytes
KW - tuberculosis
KW - tumour necrosis factor
KW - vaccination
KW - Malawi
KW - man
KW - Mycobacterium bovis BCG strain
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium bovis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - antigenicity
KW - bacterium
KW - cachectin
KW - cachexin
KW - immune sensitization
KW - immunogens
KW - Nyasaland
KW - T cells
KW - tumor necrosis factor
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023169999&site=ehost-live&scope=site
UR - email: JMJ1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeys.
AU - Markoff, L.
AU - Pang, X.
AU - Houng, H. S.
AU - Falgout, B.
AU - Olsen, R.
AU - Jones, E.
AU - Polo, S.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2002///
VL - 76
IS - 7
SP - 3318
EP - 3328
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Markoff, L.: Laboratory of Vector-Borne Virus Diseases, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Building 29A, Room 1B17, Bethesda, MD 20892, USA.
N1 - Accession Number: 20023191279. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 9007-49-2. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - We recently described the derivation of a dengue serotype 2 virus (DEN2mutF) that exhibited a host range-restricted phenotype; it was severely impaired for replication in cultured mosquito cells (C6/36 cells). DEN2mutF virus had selected mutations in genomic sequences predicted to form a 3′ stem-loop structure (3′-SL) that is conserved among all flavivirus species. The 3′-SL constitutes the downstream terminal ~95 nucleotides of the 3′ noncoding region in flavivirus RNA. Here we report the introduction of these same mutational changes into the analogous region of an infectious DNA derived from the genome of a human-virulent dengue serotype 1 virus (DEN1), strain Western Pacific (DEN1WP). The resulting DEN1 mutant (DEN1mutF) exhibited a host range-restricted phenotype similar to that of DEN2mutF virus. DEN1mutF virus was attenuated in a monkey model for dengue infection in which viraemia is taken as a correlate of human virulence. In spite of the markedly reduced levels of viraemia that it induced in monkeys compared to DEN1WP, DEN1mutF was highly immunogenic. In addition, DEN1mutF-immunized monkeys retained high levels of neutralizing antibodies in serum and were protected from challenge with high doses of the DEN1WP parent for as long as 17 months after the single immunizing dose. Phenotypic revertants of DEN1mutF and DEN2mutF were each detected after a total of 24 days in C6/36 cell cultures. Complete nucleotide sequence analysis of DEN1mutF RNA and that of a revertant virus, DEN1mutFRev, revealed that (i) the DEN1mutF genome contained no additional mutations upstream from the 3′-SL compared to the DEN1WP parent genome and (ii) the DEN1mutFRev genome contained de novo mutations, consistent with our previous hypothesis that the defect in DEN2mutF replication in C6/36 cells was at the level of RNA replication. A strategy for the development of a tetravalent dengue vaccine is discussed.
KW - animal models
KW - dengue
KW - DNA
KW - genomes
KW - humoral immunity
KW - immunization
KW - laboratory animals
KW - molecular genetics
KW - mutants
KW - mutations
KW - neutralizing antibodies
KW - nucleotide sequences
KW - phenotypes
KW - vaccination
KW - vaccines
KW - viral antigens
KW - viral replication
KW - dengue 1 virus
KW - monkeys
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023191279&site=ehost-live&scope=site
UR - email: markoff@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emerging foodborne pathogens.
AU - Tauxe, R. V.
A2 - Axelsson, L.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2002///
VL - 78
IS - 1/2
SP - 31
EP - 41
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Tauxe, R. V.: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Mailstop A-38, 1600 Clifton Road, Atlanta, GA 30306, USA.
N1 - Accession Number: 20023132733. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Public Health
N2 - The broad spectrum of foodborne infections has changed dramatically over time, as well-established pathogens have been controlled or eliminated, and new ones have emerged. The burden of foodborne disease remains substantial: one in 4 Americans is estimated to have a significant foodborne illness each year. The majority of these illnesses are not accounted for by known pathogens, so more must remain to be discovered. Among the known foodborne pathogens, those more recently identified predominate, suggesting that as more and more is learned about pathogens, they come under control. In addition to the emergence or recognition of new pathogens, other trends include global pandemics of some foodborne pathogens, the emergence of antimicrobial resistance, the identification of pathogens that are highly opportunistic, affecting only the most high-risk subpopulations, and the increasing identification of large and dispersed outbreaks. New pathogens can emerge because of changing ecology or changing technology that connects a potential pathogen with the food chain. They also can emerge de novo by transfer of mobile virulence factors, often through bacteriophage. Though this is rarely observed, it can be reconstructed. Better understanding of the ecology and dynamics of phage transmission among bacteria will help us to understand the appearance of new pathogens in the future. One may look for emerging foodborne pathogens among the silent zoonoses, and among the severe infections affecting the immunocompromised humans. In the past, separating human sewage and animal manure from human food and water supplies was critical to improving public health. Now, our health depends increasingly on the safety of the feed and water supplies for the animals themselves. The successes of the 20th century and the new challenges we face mean that public health vigilance, careful investigation of new problems, responsible attention to food safety from farm to table, and partnerships to bring about new foodborne disease control measures will be needed for the foreseeable future.
KW - drug resistance
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - microbial ecology
KW - outbreaks
KW - pathogens
KW - reviews
KW - technology
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - food contaminants
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023132733&site=ehost-live&scope=site
UR - email: rvt1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced recovery of Salmonella from apple cider and apple juice with Universal Preenrichment broth.
AU - Hammack, T. S.
AU - Johnson, M. L.
AU - Jacobson, A. P.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 2
SP - 384
EP - 387
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hammack, T. S.: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C St, SW, HFS-516, Washington, DC 20204, USA.
N1 - Accession Number: 20023057802. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 62-42-3. Subject Subsets: Sugar Industry; Dairy Science
N2 - A comparison was made of the relative efficiencies of Universal Preenrichment (UP) broth and lactose broth for the recovery of a variety of Salmonella serovars from pasteurized and unpasteurized apple cider and pasteurized apple juice. Bulk portions of juice were contaminated with single Salmonella serovars at high and low levels of 0.4 and 0.04 CFU/mL, respectively. The juice was aged for a minimum of 5 days at 2-5°C. On the day analysis was initiated, each of 20 test portions (25 mL) of the contaminated juice was preenriched in UP broth and in lactose broth. The Bacteriological Analytical Manual Salmonella culture method was followed thereafter. For pasteurized apple cider, UP broth recovered significantly (p<0.05) more Salmonella-positive test portions than did lactose broth (112 and 75, respectively). For unpasteurized apple cider, UP broth recovered significantly more Salmonella-positive test portions than did lactose broth (326 and 221, respectively). For pasteurized apple juice, UP broth recovered more Salmonella-positive test portions than did lactose broth (93 and 81, respectively). However, this difference was not statistically significant. These results indicate that UP broth should replace lactose broth for the analysis of pasteurized and unpasteurized apple cider and pasteurized apple juice.
KW - apple juice
KW - cider
KW - food contamination
KW - lactose
KW - serovars
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - milk sugar
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023057802&site=ehost-live&scope=site
UR - email: Thomas.Hammack@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of enteroviruses in shellfish by fluorogenic polymerase chain reaction integrated with 96-well microplate scanning.
AU - Shieh, Y. C.
AU - Baric, R. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 5
SP - 1045
EP - 1051
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Shieh, Y. C.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, PO Box 158, Dauphin Island, AL 36528-0518, USA.
N1 - Accession Number: 20023155708. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - A one-step procedure was developed to confirm viral targets by using a fluorometric 96-well microplate scanner following polymerase chain reaction (PCR). The fluorogenic PCR, integrated with fluorometric scanning, measured the end point fluorescence of viral PCR amplicon/probe hybrids and permitted the use of nonfluorogenic PCR conditions with addition of a Cy3 fluorophore-labelled linear probe for viruses. This linear probe generated higher ratios of viral signal-to-noise than a comparative beacon probe. Detection efficiency with a Cy3/quencher linear probe was comparable with Southern analysis at the level ≥0.27 plaque-forming units (PFU) of poliovirus/PCR. For the reaction containing <0.27 PFU, the fluorometric measurements of the first-round PCR viral amplicon were not as sensitive as Southern analysis; however, equivalent sensitivities were achieved with fluorogenic nested PCR. Concentrates of 11 oyster samples exposed to municipal sewage were tested for enteroviruses; the fluorogenic detection correlated 100% with Southern analysis. This method using fluorometric scanning of viral amplicon is simple; it requires neither continuously monitoring equipment nor redesigning PCR primers; and it accurately detects enteroviruses in oyster sample concentrates in less time than classic spectrophotometry or Southern analysis.
KW - detection
KW - exposure
KW - oysters
KW - polymerase chain reaction
KW - sewage
KW - shellfish
KW - Enterovirus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - amplicons
KW - PCR
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Wastes and Refuse (XX300)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023155708&site=ehost-live&scope=site
UR - email: yshieh@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous determination of vitamin A and β-carotene in dietary supplements by liquid chromatography.
AU - Sundaresan, P. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 5
SP - 1127
EP - 1135
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Sundaresan, P. R.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, College Park, MD 20740, USA.
N1 - Accession Number: 20023155719. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 7235-40-7, 68-26-8, 127-47-9, 79-81-2. Subject Subsets: Human Nutrition
N2 - Several liquid chromatography (LC) methods for analysis of vitamin A in foods and feeds have been previously reported but only a few have been applied in non-food matrixes. A validated LC method is needed for determination of vitamin A and β-carotene in the various matrixes presented by dietary supplements. The performance of a reversed-phase method with methanol-isopropanol gradient elution was evaluated with standard retinyl derivatives and β-carotene. The reversed-phase method is capable of separating retinol from other derivatives such as retinyl acetate, retinyl palmitate and β-carotene. Two types of extraction were used to extract the analytes from the dietary supplements: a hexane-methylene chloride extraction for soft-gel capsules containing β-carotene, and a direct solvent extraction for dietary supplements in tablet form. The direct solvent extraction consisted of treatment with ethanol and methylene chloride following addition of hot water (55°C). Results with the reversed-phase method for vitamin A and β-carotene in the products examined (n=8) indicated excellent method performance. The main form of vitamin A or β-carotene in dietary supplements was the all-trans isomer. The reversed-phase method avoids saponification and is rapid, accurate, precise and suitable for simultaneous determination of retinyl derivatives and β-carotene in dietary supplements.
KW - analytical methods
KW - beta-carotene
KW - food supplements
KW - isomers
KW - liquid chromatography
KW - retinol
KW - retinyl acetate
KW - retinyl palmitate
KW - analytical techniques
KW - axerophthol
KW - retinol acetate
KW - retinol palmitate
KW - vitamin A
KW - vitamin A acetate
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Food Composition and Quality (QQ500)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023155719&site=ehost-live&scope=site
UR - email: psundare@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of visual immunoassay and chromogenic culture medium for the presence of Listeria spp. in foods.
AU - Istafanos, P.
AU - James, L.
AU - Hunt, J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 5
SP - 1201
EP - 1203
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Istafanos, P.: U.S. Food and Drug Administration, 158-15 Liberty Ave, Jamaica, NY 11433, USA.
N1 - Accession Number: 20023155727. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Soyabeans; Dairy Science
N2 - Two rapid screening methods (the TECRATM Listeria Visual Immunoassay (LIS-VIA) kit, an AOAC-approved 48 h visual test, which detects Listeria through colorimetry, and BCMTMListeria isolation and differentiation plating agar) were used to screen U.S. Food and Drug Administration-regulated commodities for the presence of Listeria spp. Seventy-four different food samples (cheeses, processed seafood, tofu, vegetable salads, soya milk) were screened for the presence of Listeria spp. by using both protocols. Test results for the TECRA LIS-VIA showed 66 negative samples and 1 false positive, with 4 confirmed as L. monocytogenes and 3 as L. innocua. With the BCM agar, 67 samples were negative, 4 were confirmed as L. monocytogenes, and 3 were confirmed as L. innocua. Both methods showed similar results and were effective screening tools for Listeria spp. in foods. The BCM agar method proved to be a rapid, sensitive, and excellent tool for early screening and differentiation of Listeria spp. present in foods.
KW - culture media
KW - food contamination
KW - foods
KW - immunoassay
KW - microbial contamination
KW - pathogens
KW - screening
KW - Listeria
KW - Listeria innocua
KW - Listeria monocytogenes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - bacterium
KW - food contaminants
KW - screening tests
KW - visual immunoassay
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023155727&site=ehost-live&scope=site
UR - email: pistafan@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interlaboratory comparison of methods for the determination of incurred tilmicosin residues in bovine liver.
AU - Clark, S. B.
AU - O'Rangers, J. J.
AU - Rowe, W. D.
AU - Madson, M. R.
AU - Hurlbut, J. A.
AU - Sofos, J. N.
AU - Fuerst, B.
AU - James, G.
AU - Griffith, S.
AU - Readnour, R. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 6
SP - 1260
EP - 1267
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Clark, S. B.: U.S. Food and Drug Administration, PO Box 25087, Denver, CO 80225, USA.
N1 - Accession Number: 20023193936. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 56-23-5, 110-54-3. Subject Subsets: Veterinary Science; Veterinary Science
N2 - A study was conducted to compare 2 methods for the determination of tilmicosin residues in bovine liver samples. Three laboratories participated in the comparison study. The first method was described in a New Animal Drug Application (NADA 140-929), and the 2nd was a modification of that method in which hexane was substituted for carbon tetrachloride in one cleanup step. Each of the 3 laboratories analysed subsamples of 10 bovine livers containing tilmicosin. Residues ranged from 2.3 to 81 ppm tilmicosin with an 11.8% relative standard deviation obtained from both methods. In addition, fortified-control liver tissue samples were analysed concurrently with tissues containing incurred residues by using the modified method in one of the laboratories. The fortification levels ranged from 0.3 to 112 ppm, with recoveries ranging from 76 to 92%. The results from the 3 laboratories were comparable, indicating that the modified method was not only as effective as the original NADA method, but also more desirable because of the change to a less hazardous solvent.
KW - analytical methods
KW - antibacterial agents
KW - antibiotic residues
KW - carbon tetrachloride
KW - drug residues
KW - hexane
KW - liver
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - tetrachloromethane
KW - tilmicosin
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023193936&site=ehost-live&scope=site
UR - email: sclark1@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concurrent determination of four fluoroquinolones in catfish, shrimp, and salmon by liquid chromatography with fluorescence detection.
AU - Roybal, J. E.
AU - Walker, C. C.
AU - Pfenning, A. P.
AU - Turnipseed, S. B.
AU - Storey, J. M.
AU - Gonzales, S. A.
AU - Hurlbut, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 6
SP - 1293
EP - 1301
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Roybal, J. E.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20023193937. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 98106-17-3, 93106-60-6, 85721-33-1, 91296-86-5. Subject Subsets: Veterinary Science; Veterinary Science
N2 - A liquid chromatographic (LC) method with fluorescence detection was developed for concurrent determination of 4 fluoroquinolones: ciprofloxacin (CIPRO), enrofloxacin (ENRO), sarafloxacin (SARA), and difloxacin (DIFLX) in catfish, shrimp, and salmon. The procedure consists of extraction from fish tissue with acidified ethanol, isolation and retention on a cation exchange solid-phase extraction column, elution with basic methanol, and LC analysis with fluorescence detection. LC is performed by isocratic elution with acetonitrile-2% acetic acid (16+84) mobile phase, and a PLRP-S polymer column with fluorescence detection, excitation 278 nm and emission 450 nm. A target level of 20 ppb for each of the 4 fluoroquinolones has been established for this method. Fortified and incurred fish sample results are based on a 5-point standard curve calculation (10-160 ppb). Overall percent recoveries (% relative standard deviation) from fortified catfish were 78 (10), 80 (11), 70 (9.4), and 78 (10); from fortified shrimp, 69 (5.9), 85 (4.9), 79 (5.9), and 90 (4.5); and from fortified salmon, 56 (15), 93 (5.6), 61 (11), and 87 (5.0) for CIPRO, ENRO, SARA, and DIFLX, respectively. Data from the analysis of fluoroquinolone-incurred catfish, shrimp, and salmon are presented.
KW - antibacterial agents
KW - antibiotic residues
KW - ciprofloxacin
KW - difloxacin
KW - drug residues
KW - enrofloxacin
KW - fluorescence
KW - liquid chromatography
KW - quinolones
KW - shrimps
KW - Ictalurus punctatus
KW - salmon
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - Salmonidae
KW - Salmoniformes
KW - sarafloxacin
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023193937&site=ehost-live&scope=site
UR - email: jroybal@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of deoxynivalenol in whole wheat flour and wheat bran.
AU - Rupp, H. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 6
SP - 1355
EP - 1359
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Rupp, H. S.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr, SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20023193942. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 51481-10-8. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research; Wheat, Barley & Triticale Abstracts
N2 - A liquid chromatographic (LC) method was developed for determining deoxynivalenol (DON) in whole wheat flour and wheat bran. A 15 g test sample was extracted with acetonitrile-water (84+16, v/v) and applied to a Romer MycoSep cleanup column. The eluate was dried and then reconstituted in a 0.1 M phosphate buffer, pH 7.0, and applied to a Vicam DONtest-LC cleanup column. The methanol eluate was chromatographed with a methanol-water (17+83, v/v) mobile phase on a C18 column with UV detection at 220 nm. Five replicates at each of 5 fortification levels (0.25, 0.50, 1.0, 2.0, and 4.0 ppm), plus 5 controls, were determined for both whole wheat flour and wheat bran. For flour, the average recoveries were 72.2-91.5% with relative standard deviations (RSDs) of 4.9-18.4%. The intra-assay flour recovery was 82.4% with 9.8% RSD. A 5 replicate sample of naturally incurred wheat had an average of 1.1 ppm DON with 6.7% RSD. For bran, average recoveries of fortified samples were 69.5-99.7% with RSDs of 1.7-18.8%. The intra-assay bran recovery was 81.5% with 8.9% RSD. The limit of detection (about 3× noise) for the method is 0.05 ppm; the correlation coefficient (linearity) was >0.9995. The DON peak was clearly identified and easily integrated in the chromatograms.
KW - determination
KW - liquid chromatography
KW - vomitoxin
KW - wheat bran
KW - wheat flour
KW - deoxynivalenol
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023193942&site=ehost-live&scope=site
UR - email: hrupp@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of St. John's wort components in dietary supplements and functional foods by liquid chromatography.
AU - Ang, C. Y. W.
AU - Cui, Y. Y.
AU - Chang, H. C.
AU - Luo, W. H.
AU - Heinze, T. M.
AU - Lin, L. J.
AU - Mattia, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2002///
VL - 85
IS - 6
SP - 1360
EP - 1369
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Ang, C. Y. W.: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Chemistry, HFT-230, 3900 NCTR Rd, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023193943. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Aromatic & Medicinal Plants; Human Nutrition
N2 - St. John's wort, Hypericum perforatum, preparations, a top-selling botanical dietary supplement used primarily as an antidepressant, has recently been used as an ingredient in some food products sold as functional foods. A rapid extraction technique followed by a liquid chromatographic (LC) method was developed to determine 4 characteristic bioactive compounds (pseudohypericin, hypericin, hyperforin, and adhyperforin) from St. John's wort in dietary supplements and functional foods to which it was added. Solid samples, including dried leaf/flower mixture, dietary supplement capsules, tea bags, puff and snack bar, were extracted with methanol by sonication. Noncarbonated, fruit-flavoured drinks were centrifuged and mixed with methanol. Compounds were then determined by isocratic, reversed-phase LC with UV detection at 2 wavelengths and further identified or confirmed by photodiode array spectra and LC/mass spectrometry. Within-laboratory method variations (% RSD) were satisfactory. Very low amounts, if any, of the 4 components were found in drink and puff samples, and none was found in the snack bar. The methods developed provide a useful means for the determination of St. John's wort components in dietary supplements and functional foods.
KW - beverages
KW - determination
KW - food supplements
KW - functional foods
KW - liquid chromatography
KW - snacks
KW - tea
KW - Camellia sinensis
KW - Hypericum perforatum
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Hypericum
KW - Clusiaceae
KW - drinks
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023193943&site=ehost-live&scope=site
UR - email: cang@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Experimental infection of Anopheles farauti with different species of Plasmodium.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Nace, D.
AU - Williams, T.
AU - Sullivan, J. J.
AU - Galland, G. G.
AU - Grady, K. K.
AU - Bounngaseng, A.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2002///
VL - 88
IS - 2
SP - 295
EP - 298
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023087670. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science; Protozoology
N2 - Studies were conducted to determine the susceptibility of Anopheles farauti to different species and strains of Plasmodium. Mosquitoes were infected by feeding on animals or cultures infected with different strains of P. vivax, P. falciparum, P. ovale, P. coatneyi, P. gonderi, P. simiovale, P. knowlesi, and P. brasilianum. Infections of P. vivax and P. coatneyi were transmitted via sporozoites from A. farauti to monkeys. Comparative infection studies indicated that A. farauti was less susceptible to infection than A. stephensi, A. gambiae, A. freeborni, and A. dirus with the Salvador I strain of P. vivax, but more susceptible than A. stephensi and A. gambiae to infection with the coindigenous Indonesian XIX strain.
KW - disease models
KW - experimental infection
KW - sporozoites
KW - susceptibility
KW - Anopheles dirus
KW - Anopheles farauti
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles stephensi
KW - Culicidae
KW - monkeys
KW - Plasmodium
KW - Plasmodium brasilianum
KW - Plasmodium coatneyi
KW - Plasmodium falciparum
KW - Plasmodium knowlesi
KW - Plasmodium ovale
KW - Plasmodium simiovale
KW - Plasmodium vivax
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Plasmodium
KW - experimental transmission
KW - mosquitoes
KW - Plasmodium gonderi
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023087670&site=ehost-live&scope=site
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in diabetes prevalence among American Indian and Alaska Native children, adolescents, and young adults.
AU - Acton, K. J.
AU - Burrows, N. R.
AU - Moore, K.
AU - Querec, L.
AU - Geiss, L. S.
AU - Engelgau, M. M.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2002///
VL - 92
IS - 9
SP - 1485
EP - 1490
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Acton, K. J.: Indian Health Service, Rockville, Maryland, USA.
N1 - Accession Number: 20023145695. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Objectives: This study determined trends in diabetes prevalence among young American Indians and Alaska Natives in the USA. Methods: American Indian and Alaska Native children (<15 years), adolescents (15-19 years), and young adults (20-34 years) with diabetes were identified from the Indian Health Service (IHS) outpatient database. The population living within IHS contract health service delivery areas was determined from census data. Results: From 1990 to 1998, the total number of young American Indians and Alaska Natives with diagnosed diabetes increased by 71% (4534 to 7736); prevalence increased by 46% (6.4 per 1000 to 9.3 per 1000 population). Increases in prevalence were greater among adolescents and among young men. Conclusions: Diabetes should be considered a major public health problem among young American Indians and Alaska Natives.
KW - adolescents
KW - American indians
KW - children
KW - diabetes
KW - disease prevalence
KW - disease surveys
KW - human diseases
KW - young adults
KW - Alaska
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease surveillance
KW - teenagers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023145695&site=ehost-live&scope=site
UR - email: nrios@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Applied technique for increasing calicivirus detection in shellfish extracts.
AU - Burkhardt, W., III
AU - Blackstone, G. M.
AU - Skilling, D.
AU - Smith, A. W.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2002///
VL - 93
IS - 2
SP - 235
EP - 240
CY - Oxford; UK
PB - Blackwell Science
SN - 1364-5072
AD - Burkhardt, W., III: US Food and Drug Administration, Gulf Coast Seafood Laboratory, PO Box 158, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20023114319. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 7732-18-5. Subject Subsets: Veterinary Science; Human Nutrition; Veterinary Science
N2 - Aims: Optimal detection of enteric RNA viruses in clinical, environmental, and food products using reverse transcription-PCR (RT-PCR) when inhibitory substances in extracted sample materials are present. Methods and Results: We adapted a device for detection of RNA viruses in plant tissues and insects to detect a calicivirus strain (San Miguel sea lion virus, serotype 17) in water and oyster tissue extracts. This single, compartmentalized tube-within-a-tube (TWT) device for RT-PCR-nested PCR was compared to a conventional protocol of RT-PCR-nested PCR. In the presence of 100 mg of shellfish tissue extract equivalent, this TWT device decreases the calicivirus assay detection limit 10-fold over that of conventional RT-PCR-nested PCR while maintaining an identical detection limit of viral nucleic acid suspended in water. Both the conventional and TWT methods estimated the total particle-to-infectious particle ratio for this strain of calicivirus at approximately 40:1. Conclusions: We believe that the TWT device with appropriate RT-PCR primers will decrease the detection limit for other calicivirus strains and RNA viruses in shellfish tissue extracts. Significance and Impact of the Study: We believe that the TWT approach is applicable to other situations where RT and/or PCR inhibitory materials are present or nucleic acid targets of bacteria or viruses are at low levels in extracts of food products or clinical specimens.
KW - analytical methods
KW - detection
KW - food contamination
KW - food safety
KW - microbial contamination
KW - oysters
KW - polymerase chain reaction
KW - water
KW - San Miguel sealion virus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vesicular exanthema of swine virus
KW - Vesivirus
KW - Caliciviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - analytical techniques
KW - food contaminants
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023114319&site=ehost-live&scope=site
UR - email: Wburkhar@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kidney disease in native Americans.
AU - Narva, A. S.
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
Y1 - 2002///
VL - 94
IS - 8
SP - 738
EP - 746
CY - Washington; USA
PB - National Medical Association
SN - 0027-9684
AD - Narva, A. S.: Kidney Disease Program, Indian Health Service, 801 Vassar Drive, NE, Albuquerque, NM 87106, USA.
N1 - Accession Number: 20033076984. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Over the past few decades, the disease burden among American Indians and Alaska Natives (AI/AN), in the USA, has shifted from acute infectious diseases to chronic illnesses, particularly type 2 diabetes and its complications. AI/ANs experience high rates of end-stage renal disease (ESRD), mainly driven by the increase in diabetes. The prevalence of ESRD is 3.5 times greater than that in white Americans. The burden of ESRD has become a community-wide problem among many tribes, and significant efforts have gone into establishing dialysis services on reservations. Reservation-based dialysis services have improved the access of patients to renal replacement therapy, but enormous barriers to improving care remain. These include: the rural and frequently isolated locations that make traveling to facilities difficult owing to distance and road conditions; high rates of poverty; difficulty in recruiting and retaining staff in outlying areas; language and cultural differences; and the high numbers of patients with diabetes and extra-renal diabetic complications. Disparities exist in access to kidney transplantation, with AI/ANs waiting longer for organs than their white counterparts. However, once transplanted, they have comparable survival rates to white Americans. An aggressive approach to intervention, which includes prevention and optimal therapy, is required to slow the growth of ESRD amongst AI/ANs.
KW - complications
KW - diabetes
KW - disease prevalence
KW - human diseases
KW - kidney diseases
KW - kidney transplant
KW - Alaska
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033076984&site=ehost-live&scope=site
UR - email: anarva@abq.his.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the Integrated Management of Childhood Illness guidelines for treatment of intestinal helminth infections among sick children aged 2-4 years in western Kenya.
AU - Garg, R.
AU - Lee, L. A.
AU - Beach, M. J.
AU - Wamae, C. N.
AU - Ramakrishnan, U.
AU - Deming, M. S.
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
Y1 - 2002///
VL - 96
IS - 5
SP - 543
EP - 548
CY - London; UK
PB - Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
AD - Garg, R.: International Child Survival and Emerging Infections Program Support Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 4770 Buford Hwy, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023182324. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 31431-39-7. Subject Subsets: Protozoology; Rural Development; Tropical Diseases; Helminthology
N2 - Anthelmintic treatment of sick preschool-age children at health facilities is a potentially effective strategy for intestinal helminth control in this age-group. We conducted a study from July 1998 to February 1999 in western Kenya to determine whether the Integrated Management of Childhood Illness (IMCI) guidelines' clinical assessment can be used to identify helminth-infected children, and to evaluate the nutritional benefit of treating sick children without pallor with an anthelmintic (mebendazole is already part of IMCI treatment for sick children aged 2-4 years with palmar pallor in areas where hookworm and Trichuris trichiura infections are endemic). Sick children aged 2-4 years seen at 3 rural health facilities were clinically evaluated and tested for haemoglobin concentration, malaria parasites, and intestinal helminths. Children without pallor were randomly assigned to receive a single dose of 500 mg of mebendazole or a placebo and re-examined 6 months later. Among the 574 children enrolled, 11% had one or more intestinal helminths. Most infections were of light intensity. Selected clinical signs and symptoms available from the IMCI assessment, including palmar pallor and low weight-for-age, were not associated with helminth infection. Six months after enrolment, no differences in growth of children without pallor were observed between the mebendazole (n=166) and placebo (n=181) groups. However, there was a significantly greater mean increase in weight, height, and weight-for-age Z score among the helminth-infected children in the mebendazole group (n=22) as compared with helminth-infected children in the placebo group (n=20). We conclude that even lightly infected preschool-age children without palmar pallor benefit from anthelmintic treatment; however, in this study setting of low helminth prevalence and intensity, helminth-infected children could not be identified using the IMCI guidelines. Cost-effectiveness studies are needed to help define helminth prevalence thresholds for routine anthelmintic treatment of sick preschool-age children seen at first-level health facilities.
KW - anthelmintics
KW - children
KW - drug therapy
KW - guidelines
KW - haemoglobin
KW - helminthoses
KW - helminths
KW - human diseases
KW - malaria
KW - mebendazole
KW - preschool children
KW - rural areas
KW - school children
KW - Kenya
KW - Enoplida
KW - man
KW - Plasmodium
KW - Trichuris trichiura
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Trichuris
KW - Trichuridae
KW - Trichinellida
KW - Dorylaimia
KW - Enoplea
KW - Nematoda
KW - Enoplia
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - Adenophorea
KW - chemotherapy
KW - hemoglobin
KW - nematodes
KW - parasitic worms
KW - recommendations
KW - school kids
KW - schoolchildren
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023182324&site=ehost-live&scope=site
UR - email: msd1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a real time quantitative PCR assay for detection of porcine endogenous retrovirus.
AU - Argaw, T.
AU - Ritzhaupt, A.
AU - Wilson, C. A.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2002///
VL - 106
IS - 1
SP - 97
EP - 106
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Argaw, T.: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 20023166481. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Pig Science; Veterinary Science
N2 - Real time polymerase chain reaction (PCR) technology was applied to the development of assays for detection and quantitation of porcine endogenous retrovirus (PERV) RNA and DNA sequences in tissues and cells of human or animal origin. A plasmid construct encoding the PERV-pol gene or the in vitro transcribed RNA derived from the plasmid (cRNA) serves as a standard template for amplification of a 178 bp fragment. This study showed that the detection of this target sequence was linear over a range from 20 copies to 2 million copies of the plasmid and from 100 copies to 1 million copies of the cRNA. In addition, amplification of the target sequence was not inhibited by the presence of exogenous genomic DNA. These results demonstrate that a real time (TaqMan-based) PCR or RT-PCR assay can provide a sensitive, reproducible, and robust method for detecting and quantifying PERV DNA or RNA sequences in samples of human or guineapig origin.
KW - analytical methods
KW - animal models
KW - cells
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - DNA
KW - genes
KW - molecular genetics
KW - nucleotide sequences
KW - plasmids
KW - polymerase chain reaction
KW - quantitative analysis
KW - quantitative techniques
KW - RNA
KW - tissues
KW - guineapigs
KW - man
KW - Retroviridae
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Retroviridae
KW - analytical techniques
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - guinea pigs
KW - PCR
KW - porcine endogenous retrovirus
KW - ribonucleic acid
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023166481&site=ehost-live&scope=site
UR - email: wilsonc@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recalls of foods containing undeclared allergens reported to the US Food and Drug Administration, fiscal year 1999.
AU - Vierk, K.
AU - Falci, K.
AU - Wolyniak, C.
AU - Klontz, K. C.
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2002///
VL - 109
IS - 6
SP - 1022
EP - 1026
CY - St Louis; USA
PB - Mosby Inc.
SN - 0091-6749
AD - Vierk, K.: US Food and Drug Administration's Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, Room 2C-077, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20023104708. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Soyabeans; Public Health; Human Nutrition; Wheat, Barley & Triticale Abstracts; Dairy Science
N2 - Food recall records of the US Food and Drug Administration for the fiscal year 1999 were retrospectively reviewed to identify recalls containing undeclared allergens, such as milk, eggs, fish, wheat, crustacean, shellfish, tree nuts, groundnuts and soya. Each record was evaluated to determine the recalled product, the undeclared allergen present, the reason for recall, and reported adverse events. Of 659 food products classified for recall, 236 (36%) were recalled because they contained undeclared allergens. In 56% of recalled products, the consumers were the party responsible for the identification of the undeclared allergen. A total of 34 consumers reported allergic reactions after consumption of the recalled food products. Factors contributing to the presence of undeclared allergens in the recalled products included ingredient-statement omissions and errors (51%), cross-contact with manufacturing equipment (40%), and errors by ingredient suppliers or manufacturing firm employees (5%). These results imply that the presence of undeclared allergens in food products represents one of the more common reasons for food product recall in the USA.
KW - allergens
KW - consumers
KW - eggs
KW - fish
KW - food allergies
KW - food products
KW - groundnuts
KW - human diseases
KW - milk
KW - nuts
KW - shellfish
KW - soya protein
KW - wheat
KW - USA
KW - Arachis hypogaea
KW - Triticum
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food hypersensitivity
KW - peanuts
KW - soy protein
KW - soyabean protein
KW - soybean protein
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Milk and Dairy Produce (QQ010)
KW - Eggs and Egg Products (QQ040)
KW - Crop Produce (QQ050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023104708&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Goitrogenic and estrogenic activity of soy isoflavones.
AU - Doerge, D. R.
AU - Sheehan, D. M.
A2 - Bauer, R.
A2 - Colborn, T.
A2 - Palanza, P.
A2 - Parmigiani, S.
A2 - vom Saal, F.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2002///
VL - 110
SP - 349
EP - 353
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Doerge, D. R.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20023107785. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 54 notes and ref. Registry Number: 446-72-0, 903-99-0, 9034-48-4, 51-48-9, 55-06-1, 6893-02-3. Subject Subsets: Soyabeans; Human Nutrition; Public Health; Postharvest Research
N2 - Soy is known to produce oestrogenic isoflavones. Here, we briefly review the evidence for binding of isoflavones to the oestrogen receptor, in vivo estrogenicity and developmental toxicity, and oestrogen developmental carcinogenesis in rats. Genistein, the major soy isoflavone, also has a frank oestrogenic effect in women. We then focus on evidence from animal and human studies suggesting a link between soy consumption and goitre, an activity independent of oestrogenicity. Iodine deficiency greatly increases soy antithyroid effects, whereas iodine supplementation is protective. Thus, soy effects on the thyroid involve the critical relationship between iodine status and thyroid function. In rats consuming genistein-fortified diets, genistein was measured in the thyroid at levels that produced dose-dependent and significant inactivation of rat and human thyroid peroxidase (TPO) in vitro. Furthermore, rat TPO activity was dose-dependently reduced by up to 80%. Although these effects are clear and reproducible, other measures of thyroid function in vivo (serum levels of triiodothyronine, thyroxine, and thyroid-stimulating hormone; thyroid weight; and thyroid histopathology) were all normal. Additional factors appear necessary for soy to cause overt thyroid toxicity. These clearly include iodine deficiency but may also include additional soy components, other defects of hormone synthesis, or additional goitrogenic dietary factors. Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both oestrogenic and goitrogenic activities is of concern. Rigorous, high-quality experimental and human research into soy toxicity is the best way to address these concerns. Similar studies in wildlife populations are also appropriate.
KW - animal models
KW - enzyme activity
KW - food consumption
KW - genistein
KW - goitre
KW - histopathology
KW - human diseases
KW - isoflavones
KW - laboratory animals
KW - peroxidase
KW - reviews
KW - soyabean products
KW - soyabeans
KW - thyroid gland
KW - thyrotropin
KW - thyroxine
KW - toxicology
KW - triiodothyronine
KW - Glycine (Fabaceae)
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - biochanin A
KW - goiter
KW - liothyronine
KW - soybean products
KW - soybeans
KW - thyroid
KW - thyroid-stimulating hormone
KW - thyrotropic hormone
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Diet Studies (VV110)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023107785&site=ehost-live&scope=site
UR - email: dansheeh@swbell.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Obesity exacerbates chemically induced neurodegeneration.
AU - Sriram, K.
AU - Benkovic, S. A.
AU - Miller, D. B.
AU - O'Callaghan, J. P.
JO - Neuroscience (Oxford)
JF - Neuroscience (Oxford)
Y1 - 2002///
VL - 115
IS - 4
SP - 1335
EP - 1346
CY - Oxford; UK
PB - Pergamon Press
SN - 0306-4522
AD - Sriram, K.: HELD/TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Mailstop L-3014, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20033027115. Publication Type: Journal Article. Language: English. Registry Number: 51-61-6. Subject Subsets: Human Nutrition
N2 - Obesity is a major risk factor associated with a variety of human disorders. While its involvement in disorders such as diabetes, coronary heart disease and cancer have been well characterized, it remains to be determined if obesity has a detrimental effect on the nervous system. To address this issue we determined whether obesity serves as a risk factor for neurotoxicity. Model neurotoxicants, methamphetamine (METH) and kainic acid (KA), which are known to cause selective neurodegeneration of anatomically distinct areas of the brain, were evaluated using an animal model of obesity, the ob/ob mouse. Administration of METH and KA resulted in mortality among ob/ob mice but not among their lean littermates. While METH caused dopaminergic nerve terminal degeneration as indicated by decreased striatal dopamine (49%) and tyrosine hydroxylase protein (68%), as well as an increase in glial fibrillary acidic protein by 313% in the lean mice, these effects were exacerbated under the obese condition (96%, 86% and 602%, respectively). Similarly, a dosage of KA that did not increase glial fibrillary acidic protein in lean mice increased the hippocampal content of this protein (93%) in ob/ob mice. KA treatment resulted in extensive neuronal degeneration as determined by Fluoro-Jade B staining, decreased hippocampal microtubule-associated protein-2 immunoreactivity and increased reactive gliosis in ob/ob mice. The neurotoxic outcome in ob/ob mice remained exacerbated even when lean and ob/ob mice were dosed with METH or KA based only on a lean body mass. Administration of METH or KA resulted in up-regulation of the mitochondrial uncoupling protein-2 to a greater extent in the ob/ob mice, an effect known to reduce ATP yield and facilitate oxidative stress and mitochondrial dysfunction. These events may underlie the enhanced neurotoxicity seen in the obese mice.
KW - animal models
KW - brain
KW - degeneration
KW - dopamine
KW - laboratory animals
KW - neurotoxicity
KW - obesity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - fatness
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033027115&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0F-4789TY4-11&_user=10&_handle=W-WA-A-A-BA-MsSAYVA-UUA-AUVZYVZBDU-AWDCAAEZA-BA-U&_fmt=summary&_coverDate=12%2F16%2F2002&_rdoc=29&_orig=browse&_srch=%23toc%234861%232002%23998849995%23365770!&_cdi=4861&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7dbda4194d229abeaf3b70d9f80436db
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Research and dissemination needs for ergonomics in agriculture.
AU - Estill, C. F.
AU - Baron, S.
AU - Steege, A. L.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2002///
VL - 117
IS - 5
SP - 440
EP - 445
CY - Cary; USA
PB - Oxford University Press
SN - 0033-3549
AD - Estill, C. F.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20033019492. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
KW - agricultural engineering
KW - cost benefit analysis
KW - costs
KW - ergonomics
KW - farm workers
KW - health centres
KW - public health
KW - research
KW - rural areas
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - costings
KW - health centers
KW - human engineering
KW - studies
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033019492&site=ehost-live&scope=site
UR - email: clf4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current knowledge of the health effects of sugar intake.
AU - Mardis, A. L.
JO - Zuckerindustrie
JF - Zuckerindustrie
Y1 - 2002///
VL - 127
IS - 3
SP - 198
EP - 200
CY - Berlin; Germany
PB - Verlag Dr. Albert Bartens KG
SN - 0344-8657
AD - Mardis, A. L.: National Institute for Occupational Safety and Health, Centers for Disease Control and Preventions, Morgantown, WV, USA.
N1 - Accession Number: 20023049445. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Sugar Industry; Human Nutrition
N2 - This research brief discusses current scientific knowledge of the health effects of sugar.
KW - beverages
KW - children
KW - dental caries
KW - diabetes
KW - diet
KW - foods
KW - health
KW - heart diseases
KW - intake
KW - nutrients
KW - nutritional state
KW - obesity
KW - sugar
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - caries
KW - coronary diseases
KW - drinks
KW - fatness
KW - nutritional status
KW - teeth caries
KW - tooth decay
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Sugar and Sugar Products (QQ020)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023049445&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of the AIN-93M purified diet and dietary restriction on survival in Sprague-Dawley rats: implications for chronic studies.
AU - Duffy, P. H.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - McCracken, A.
AU - Thorn, B. T.
AU - Reeves, P. G.
AU - Blakely, S. A.
AU - Casciano, D. A.
AU - Feuers, R. J.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2002///
VL - 132
IS - 1
SP - 101
EP - 107
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Duffy, P. H.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023130943. Publication Type: Journal Article. Language: English. Registry Number: 9000-71-9. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants; Dairy Science
N2 - Survival, growth and dietary intake (DI) variables were monitored in a chronic 114-wk study in which male Sprague-Dawley rats [n=120; National Center for Toxicological Research (NCTR) colony] consumed the AIN-93M purified diet ad libitum (AL), or an amount reduced by 31% of total AL intake inclusive of all macro- and micronutrients. The main objectives were to ascertain the survival characteristics of rats fed the AIN-93M diet and to determine whether dietary restriction (DR) increases longevity of rats fed this casein-based diet compared with the use of mixed-protein sources of the NIH-31 cereal-based diet in an earlier study. Body, liver, brain, the brain/body ratio, spleen, thymus and kidney weights, body length and body density were decreased (P<0.05) by DR, whereas testis weight and skull length were not altered by DR. Significant age effects at 58 and 114 wk were found for body, brain, the brain/body ratio, liver and testis weights, and body density. Survival rates for the AL and 31% DR groups were 43.3 and 57.5%, respectively. Survival curves were not significantly different. The survival rate for AL rats fed the AIN-93M diet was not different from that of AL rats fed the NIH-31 diet (43.3 and 51.7%, respectively). However, the survival rate for 31% DR rats fed the AIN-93M diet was significantly lower than 25% DR rats fed the NIH-31 diet (57.5 and 87.5%, respectively) although both groups had similar body weights and energy intake at various ages. Nutritional components in the NIH-31 diet that are missing and/or reduced in the AIN-93M diet may interact with DR to increase 114-wk survival. Although the survivability, growth and anatomical results of this study suggest that the AIN-93M diet is suitable for chronic rodent studies, additional studies such as comprehensive histopathologic and physiologic investigations must be undertaken to complete the evaluation process.
KW - animal models
KW - brain
KW - casein
KW - cereals
KW - diets
KW - food restriction
KW - kidneys
KW - laboratory animals
KW - liver
KW - spleen
KW - survival
KW - testes
KW - rats
KW - Thymus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Lamiaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - cerebrum
KW - testicles
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023130943&site=ehost-live&scope=site
UR - http://www.nutrition.org/cgi/content/abstract/132/1/101
UR - email: pduffy@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor.
AU - Branham, W. S.
AU - Dial, S. L.
AU - Moland, C. L.
AU - Hass, B. S.
AU - Blair, R. M.
AU - Fang, H.
AU - Shi, L. M.
AU - Tong, W. D.
AU - Perkins, R. G.
AU - Sheehan, D. M.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2002///
VL - 132
IS - 4
SP - 658
EP - 664
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Branham, W. S.: Division of Genetic and Reproductive Toxicology, Jefferson Laboratories, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023134272. Publication Type: Journal Article. Language: English. Registry Number: 91-64-5, 50-28-2. Subject Subsets: Human Nutrition
N2 - Consumption of phytoestrogens and mycoestrogens in food products or as dietary supplements is of interest because of both the potential beneficial and adverse effects of these compounds in estrogen-responsive target tissues. Although the hazards of exposure to potent estrogens such as diethylstilbestrol in developing male and female reproductive tracts are well characterized, less is known about the effects of weaker estrogens including phytoestrogens. With some exceptions, ligand binding to the oestrogen receptor (ER) predicts uterotrophic activity. Using a well-established and rigorously validated ER-ligand binding assay, we assessed the relative binding affinity (RBA) for 46 chemicals from several chemical structure classes of potential phytoestrogens and mycoestrogens. Although none of the test compounds bound to ER with the affinity of the standard, 17β-estradiol (E2), ER binding was found among all classes of chemical structures (flavones, isoflavones, flavanones, coumarins, chalcones and mycoestrogens). Estrogen receptor relative binding affinities were distributed across a wide range (from ~43 to 0.00008; E2=100). These data can be utilized before animal testing to rank order estimates of the potential for in vivo estrogenic activity of a wide range of untested plant chemicals (as well as other chemicals) based on ER binding.
KW - chalcones
KW - coumarin
KW - estradiol
KW - flavanoids
KW - flavones
KW - isoflavones
KW - laboratory animals
KW - oestrogen receptors
KW - oestrogenic properties
KW - oestrogens
KW - plant oestrogens
KW - uterus
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrogen receptors
KW - estrogenic properties
KW - estrogens
KW - oestradiol
KW - phytoestrogens
KW - plant estrogens
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Animal Models of Human Nutrition (VV140)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023134272&site=ehost-live&scope=site
UR - http://www.nutrition.org/cgi/content/abstract/132/4/658
UR - email: wbranham@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
AU - Poirier, L. A.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2002///
VL - 132
IS - 8, Suppl.
SP - 2336S
EP - 2339S
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Poirier, L. A.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023133831. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 29908-03-0, 62-49-7, 68-19-9, 59-30-3, 63-68-3. Subject Subsets: Public Health; Human Nutrition
N2 - In the early 1930s, the group of Banting and Best showed that the choline moiety of lecithin was responsible for the prevention of the fatty livers produced in pancreatectomized dogs treated with insulin. This was the first study linking abnormal methyl metabolism with disease. Since then, deficiencies of each of the four essential dietary sources of methyl groups (choline, methionine, vitamin B-12 and folic acid) have been associated with increased risk of a number of diseases. Choline-deficient diets were shown to enhance liver tumour formation in rats, and such diets frequently were found to lead to atherosclerosis. Although methionine deficiency per se was not extensively studied in vivo, its metabolic antagonist ethionine did cause liver cancer and pancreatic toxicity in rodents. Deficiencies of vitamin B-12 and of folic acid have long been shown to cause neurological disturbances and birth defects both in humans and in experimental animals. In 1969 inborn errors of metabolism leading to the accumulation of the demethylated metabolite of methionine, homocysteine, were proposed as contributing to the early onset of atherosclerosis. Before 1990, numerous studies described the abnormal methylation of DNA in tumours and transformed cells. Less frequently investigated, however, were the exogenous and endogenous agents leading to such abnormal methylation. These included genetic variants among rodent strains and the methyl-deficient diets that caused liver cancer. In addition, several chemicals, particularly carcinogens, were shown to alter DNA methylation. The possible links between chemically induced alterations in DNA methylation and development of other diseases were little explored. However, by 1990, a chain of causality had been established in experimental carcinogenesis linking dietary methyl deficiency with methyl insufficiency in vivo, as well as with the abnormal methylation of DNA and of specific genes. Also during this period, the diminished activity of the enzyme methylenetetrahydrofolate reductase (EC 1.5.1.20), which is responsible for the actual de novo synthesis of methyl groups, was shown to be associated with increased risk of developing atherosclerosis, neurological disorders and birth defects. The exponential rise in studies on methyl metabolism and DNA methylation since then enables us to examine here the extent to which the mechanisms by which abnormal methylation processes seem to exert their toxic effects in one disease may be applicable to other pathologies.
KW - adenosylmethionine
KW - atherosclerosis
KW - choline
KW - congenital abnormalities
KW - cyanocobalamin
KW - diet
KW - DNA methylation
KW - folic acid
KW - genetics
KW - human diseases
KW - methionine
KW - nervous system diseases
KW - toxicity
KW - vitamin B12
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arteriosclerosis
KW - birth defects
KW - cobalamin
KW - congenital malformations
KW - folacin
KW - folate
KW - neuropathy
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023133831&site=ehost-live&scope=site
UR - http://www.nutrition.org/cgi/content/abstract/132/8/2336S
UR - email: lpoirier@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevation in S-Adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology.
AU - James, S. J.
AU - Melnyk, S.
AU - Pogribna, M.
AU - Pogribny, I. P.
AU - Caudill, M. A.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2002///
VL - 132
IS - 8, Suppl.
SP - 2361S
EP - 2366S
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - James, S. J.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023133836. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 979-92-0, 62-49-7, 68-19-9, 6027-13-0, 63-68-3, 65-23-6. Subject Subsets: Human Nutrition
N2 - Chronic nutritional deficiencies in folate, choline, methionine, vitamin B-6 and/or vitamin B-12 can perturb the complex regulatory network that maintains normal one-carbon metabolism and homocysteine homeostasis. Genetic polymorphisms in these pathways can act synergistically with nutritional deficiencies to accelerate metabolic pathology associated with occlusive heart disease, birth defects and dementia. A major unanswered question is whether homocysteine is causally involved in disease pathogenesis or whether homocysteinaemia is simply a passive and indirect indicator of a more complex mechanism. S-Adenosylmethionine and S-adenosylhomocysteine (SAH), as the substrate and product of methyltransferase reactions, are important metabolic indicators of cellular methylation status. Chronic elevation in homocysteine levels results in parallel increases in intracellular SAH and potent product inhibition of DNA methyltransferases. SAH-mediated DNA hypomethylation and associated alterations in gene expression and chromatin structure may provide new hypotheses for pathogenesis of diseases related to homocysteinaemia.
KW - adenosylhomocysteine
KW - choline
KW - cyanocobalamin
KW - DNA methylation
KW - epigenetics
KW - folic acid deficiency
KW - genetic polymorphism
KW - homocysteine
KW - methionine
KW - pathology
KW - pyridoxine
KW - vitamin B12
KW - vitamin deficiencies
KW - cobalamin
KW - homocysteinaemia
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023133836&site=ehost-live&scope=site
UR - http://www.nutrition.org/cgi/content/abstract/132/8/2361S
UR - email: jjames@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Folic acid fortification, folate status and plasma homocysteine.
AU - Rader, J. I.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2002///
VL - 132
IS - 8, Suppl.
SP - 2466S
EP - 2470S
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Rader, J. I.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20023133855. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 59-30-3, 6027-13-0. Subject Subsets: Public Health; Human Nutrition; Postharvest Research
N2 - Folic acid fortification of enriched cereal-grain products (which became mandatory in the US on 1 January 1 1998) was intended to increase folate intake among childbearing-aged women to reduce their risk of neural tube birth defect (NTD)-affected pregnancies. Interest now focuses on assessing the effects of fortification on risk of NTDs and on folate intake relative to homocysteine (Hcy) concentrations and risk of vascular disease, although a causal relationship between the latter 2 has not been demonstrated. Increased serum folate levels were first reported in 1999. Data from the Framingham Offspring Study cohort showed increased mean serum folate in middle-aged and older adults; additionally, the prevalence of high Hcy concentrations had decreased by ~50% in subjects examined before (1995-1996) and after (1997-1998) fortification. Another analyses of samples collected between 1994 and 1999 identified a trend of increasing serum folate values from 1996 onward with values in 1998 160% of those measured in 1996. Comparisons between 1988-1994 National Health and Nutrition Examination Survey (NHANES) III data and 1999 NHANES showed increased serum and erythrocyte folate concentrations among childbearing-aged women. While recent data show improved folate status in a short period of time, much about long-term effects of the fortification programme remains unknown. Interest in the effects of increased folate intakes on risk of NTDs or vascular disease needs to be balanced against concerns about masking the anaemia of vitamin B-12 deficiency and the general lack of data about safety of continuous high intakes. Careful monitoring over time is necessary to determine that the programme functions as intended.
KW - cereal grains
KW - cereal products
KW - congenital abnormalities
KW - folic acid
KW - fortification
KW - homocysteine
KW - human diseases
KW - pregnancy
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth defects
KW - congenital malformations
KW - folacin
KW - folate
KW - gestation
KW - Crop Produce (QQ050)
KW - Human Reproduction and Development (VV060)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023133855&site=ehost-live&scope=site
UR - http://www.nutrition.org/cgi/content/abstract/132/8/2466S
UR - email: jrader@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oral health status of rural adults in the United States.
AU - Vargas, C. M.
AU - Dye, B. A.
AU - Hayes, K. L.
JO - Journal of the American Dental Association
JF - Journal of the American Dental Association
Y1 - 2002///
VL - 133
IS - 12
SP - 1672
EP - 1681
CY - Chicago; USA
PB - American Dental Association
SN - 0002-8177
AD - Vargas, C. M.: Health Resources and Services Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20033168607. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Background: A study was conducted to determine the effects of rural residence on oral health in the USA. Methods: Data from adults aged 18-64 years from the 1995, 1997 and 1998 National Health Interview Surveys and the Third National Health and Nutritional Examination Survey (1988-94) were analysed. National estimates for various oral health status indicators including dental insurance coverage, unmet care needs, frequency of dental visits, caries experience and prevalence of edentulism by rural/urban residence were analysed. Results: Results revealed that adults living in rural areas were more likely to report having unmet dental care needs and were less likely to have had a dental visit in the past year compared with adults living in urban areas. The prevalence of edentulism among rural adults was 16.3%; almost twice as that of urban adults. Caries experience was likely greater among adults residing in rural areas. Conclusions: Oral health disparities exist among adults living in rural and urban areas in the USA. Practice implications: By understanding the rural/urban differences in adult oral health status, practitioners, policy makers and rural health advocates will have better information to use to promote activities that better meet the needs of rural adults in the USA.
KW - adults
KW - dental caries
KW - dental health
KW - disparity
KW - health services
KW - human diseases
KW - rural areas
KW - teeth
KW - tooth diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - caries
KW - edentulism
KW - teeth caries
KW - tooth decay
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033168607&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors for Burkholderia cepacia complex colonization and infection among patients with cystic fibrosis.
AU - Walsh, N. M.
AU - Casano, A. A.
AU - Manangan, L. P.
AU - Sinkowitz-Cochran, R. L.
AU - Jarvis, W. R.
JO - Journal of Pediatrics
JF - Journal of Pediatrics
Y1 - 2002///
VL - 141
IS - 4
SP - 512
EP - 517
CY - St Louis; USA
PB - Mosby Inc.
SN - 0022-3476
AD - Walsh, N. M.: Division of Healthcare Quality Promotion (formerly Hospital Infections Program), National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20023175650. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - During 1 April 1986-31 March 1989, a case-control study was conducted with active surveillance for B. cepacia complex colonization/infection among patients at 21 cystic fibrosis (CF) centres in North America. A case patient was defined as any CF patient with B. cepacia complex colonization for the first time during the study period. Control patients were CF patients not colonized with the bacteria. For each patient, a questionnaire was completed semi-annually. In multivariate analyses, hospitalization for pulmonary exacerbations, living with a B. cepacia complex-positive person, attending a CF summer camp, and direct contact with a B. cepacia complex-colonized CF person outside of camp and home were associated with B. cepacia complex acquisition. Receiving antimicrobial aerosol therapy or cleaning and drying a home-used nebulizer between uses were associated with a decrease in B. cepacia complex acquisition. These results necessitate the implementation of preventive programs aiming to reduce direct or indirect contact between noncolonized and B. cepacia complex-colonized/infected CF patients.
KW - bacterial diseases
KW - cystic fibrosis
KW - disease transmission
KW - human diseases
KW - immunocompromised hosts
KW - opportunistic infections
KW - risk factors
KW - North America
KW - Burkholderia cepacia
KW - man
KW - Burkholderia
KW - Burkholderiaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023175650&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Understanding the seasonal pattern of childhood asthma: results from the National Cooperative Inner-City Asthma Study (NCICAS).
AU - Gergen, P. J.
AU - Mitchell, H.
AU - Lynn, H.
JO - Journal of Pediatrics
JF - Journal of Pediatrics
Y1 - 2002///
VL - 141
IS - 5
SP - 631
EP - 636
CY - St Louis; USA
PB - Mosby Inc.
SN - 0022-3476
AD - Gergen, P. J.: Center for Primary Care and Research, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland, USA.
N1 - Accession Number: 20023190757. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Objective: To contrast the seasonal patterns of asthma symptoms and utilization and determine the impact of allergen sensitivity, environmental tobacco smoke (ETS) exposure, and air pollution on the seasonal patterns of asthma. Study design: Participants in the National Cooperative Inner-City Asthma Study (NCICAS) in northern USA, were tracked between 1993 and 1997 after allergen skin testing and determination of exposure to ETS. Air pollution data were obtained from EPA monitoring sites in NCICAS cities. Results: Asthma symptoms (wheeze) and health care utilization (unscheduled visits and hospitalization) had similar seasonal patterns, with low points during the summer months of June through August and a distinct autumn peak beginning in September. Seasonal patterns were similar among children with no allergen skin test reactivity, those reactive only to indoor allergens, and those reactive to outdoor allergens. ETS exposure, whether defined by self-report or urinary cotinine/creatinine ratio, was not related to the observed seasonal patterns. Among the pollutants evaluated, only the seasonal pattern of SO2 coincided with that of asthma morbidity. Conclusions: Atopy, ETS, and most air pollutants do not appear to contribute to the distinct asthma seasonal pattern. On a population level, changes in symptoms are mirrored by changes in utilization.
KW - air pollution
KW - asthma
KW - atopy
KW - children
KW - human diseases
KW - seasonal variation
KW - tobacco smoking
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - atmospheric pollution
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023190757&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - All-cause and cause-specific death rates by educational status for two million people in two American Cancer Society cohorts, 1959-1996.
AU - Steenland, K.
AU - Henley, J.
AU - Thun, M.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2002///
VL - 156
IS - 1
SP - 11
EP - 21
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Steenland, K.: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20033067350. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - Low socioeconomic status is associated with high mortality, but the extent to which socioeconomic status affects particular diseases and whether socioeconomic status effects have changed over time are uncertain. The authors used education as a marker for socioeconomic status in a study of two large American Cancer Society cohorts (follow-up, 1959-1996). Low education was associated with higher death rates in both cohorts from all causes and most specific causes, except breast cancer and external causes among women. Life expectancy in the more recent cohort was 4.8 years shorter for men and 2.7 years shorter for women for the least versus the most educated. The inverse relation between education and mortality was strongest for coronary heart disease, lung cancer, diabetes, and chronic obstructive pulmonary disease; moderate for colorectal cancer, external causes (men only), and stroke; weak for prostate cancer; and reversed for external causes among women. The direction of a weak gradient for breast cancer differed for those with and without prevalent breast cancer at baseline. Adjustment for conventional risk factors, probable intermediate variables between education and mortality, diminished but did not eliminate the observed educational/mortality gradients. Temporal trends showed increasing mortality differences by education for coronary heart disease, diabetes, and lung cancer for women.
KW - breast
KW - breast cancer
KW - colon
KW - colorectal cancer
KW - diabetes
KW - education
KW - epidemiology
KW - heart diseases
KW - human diseases
KW - life expectancy
KW - lung cancer
KW - lungs
KW - men
KW - mortality
KW - neoplasms
KW - prostate
KW - prostate cancer
KW - rectum
KW - respiratory diseases
KW - risk assessment
KW - risk factors
KW - socioeconomic status
KW - stroke
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - breasts
KW - cancers
KW - coronary diseases
KW - death rate
KW - lung diseases
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033067350&site=ehost-live&scope=site
UR - email: nsteenland@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey.
AU - Hnizdo, E.
AU - Sullivan, P. A.
AU - Bang, K. M.
AU - Wagner, G.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2002///
VL - 156
IS - 8
SP - 738
EP - 746
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Hnizdo, E.: Division of Respiratory Disease Studies, MS H2800, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20033066973. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - Data from the US population-based Third National Health and Nutrition Examination Survey (USA), conducted from 1988 to 1994, were used to estimate the population prevalence, prevalence odds ratios, and attributable fractions for the association of chronic obstructive pulmonary disease (COPD) with employment by industry and occupation. The aim was to identify industries and occupations at increased risk of COPD. COPD was defined as forced expiratory volume in 1 second (FEV1)/forced vital capacity <70% and FEV1 <80% predicted. The authors used SUDAAN software to estimate the weighted population prevalence and odds ratios using 9823 subjects aged 30-75 years who underwent lung function tests. Odds ratios for COPD, adjusted for age, smoking status, pack-years of smoking, body mass index, education, and socioeconomic status, were increased for the following industries: rubber, plastics, and leather manufacturing; utilities; office building services; textile mill products manufacturing; the armed forces; food products manufacturing; repair services and gas stations; agriculture; sales; construction; transportation and trucking; personal services; and health care. Occupations associated with increased odds ratios for COPD were freight, stock, and material handlers; records processing and distribution clerks; sales; transportation-related occupations; machine operators; construction trades; and waitresses. The fraction of COPD attributable to work was estimated as 19.2% overall and 31.1% among never smokers.
KW - chronic obstructive pulmonary disease
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - lung function
KW - occupational hazards
KW - occupational health
KW - occupations
KW - respiratory diseases
KW - risk factors
KW - tobacco smoking
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033066973&site=ehost-live&scope=site
UR - email: Exh6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CpG oligodeoxynucleotides as vaccine adjuvants in primates.
AU - Verthelyi, D.
AU - Kenney, R. T.
AU - Seder, R. A.
AU - Gam, A. A.
AU - Friedag, B.
AU - Klinman, D. M.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2002///
VL - 168
IS - 4
SP - 1659
EP - 1663
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Verthelyi, D.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 20023039513. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG ODN that stimulate human PBMC are only weakly active in mice. Thus, alternative animal models are needed to monitor the activity and safety of human CpG ODN in vivo. This work demonstrates that rhesus macaques recognize and respond to the same CpG motifs that trigger human immune cells. Coadministering CpG ODN with heat-killed Leishmania vaccine provided significantly increased protection of macaques against cutaneous Leishmania infection. These findings indicate that rhesus macaques provide a useful model for studying the in vivo activity of human CpG motifs, and that ODN expressing these motifs act as strong immune adjuvants.
KW - adjuvants
KW - animal models
KW - antigens
KW - immune response
KW - vaccines
KW - Leishmania
KW - Macaca mulatta
KW - man
KW - mice
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Homo
KW - Hominidae
KW - Muridae
KW - rodents
KW - antigenicity
KW - CpG oligodeoxynucleotides
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - oligodeoxynucleotides
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023039513&site=ehost-live&scope=site
UR - email: Klinman@CBER.FDA.GOV
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets.
AU - Shvedova, A. A.
AU - Kisin, E.
AU - Murray, A.
AU - Goldsmith, T.
AU - Reynolds, J. S.
AU - Castranova, V.
AU - Frazer, D. G.
AU - Kommineni, C.
JO - Toxicology
JF - Toxicology
Y1 - 2002///
VL - 177
IS - 2/3
SP - 285
EP - 297
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0300-483X
AD - Shvedova, A. A.: Health Effects Laboratory Division, Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop 2015 1095, Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20033039629. Publication Type: Journal Article. Language: English. Registry Number: 1406-18-4. Subject Subsets: Human Nutrition
N2 - Metal working fluids (MWFs) have been widely known to cause asthma and neoplasia of the larynx, pancreas, rectum, skin and urinary bladder (Textbook of Clinical Occupational and Environmental Medicine (1994) 814; Am. J. Ind. Med. 32 (1997) 240; Am. J. Ind. Med. 33 (1997) 282; Am. J. Ind. Med. 22 (1994) 185). Other non-neoplastic respiratory effects in industrial workers attributed to MWFs include increased rates of cough, phlegm production, wheeze, chronic bronchitis and chest tightness (Eur. J. Resir. Dis. 63(118) (1982), 79; J. Occup. Med. 24 (1982) 473; Am. J. Ind. Med. 32 (1997) 450). The epidemic and endemic nature of immune mediated lung morbidity commonly known as hypersensitivity pneumonitis in workers from several different industries using MWFs has been well documented (J. Allergy clin. Immunol. 91 (1993) 311; Chest 108 (1995) 636; MMWR45 (1996) 606; Am. J. Ind. Med. 32 (1997) 423). We studied morphological/functional and antioxidant outcomes in lungs after inhalation exposure of vitamin E deficient mice to MWF (27 mg m-3 17 weeks, 5 days a week, 6 h a day). Mice were given vitamin E deficient (<10 IU kg-1 vitamin E) or basal diets (50 IU kg-1 vitamin E) for 35 weeks. Inhalation exposure to MWF started after 18 weeks on diet. Microscopic observation of lungs from mice given vitamin E deficient or sufficient diets revealed no inflammation or morphological alteration after exposure to MWF. Mice given vitamin E deficient diet exhibited a significant decrease (P<0.05) in breathing rate, peak inspiratory/expiratory flow, minute ventilation, and tidal volume compared with sufficient controls. However, no differences were found after exposure to MWF in pulmonary function, with the exception of tidal volume which also significantly decreased (P<0.05). Exposure to MWF reduced vitamin E, protein thiol and ascorbate level in lungs. Exposure to MWF in combination with a vitamin E deficient diet resulted in significantly enhanced accumulation of peroxidative products compared with vitamin E deficient controls. This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure.
KW - animal models
KW - antioxidants
KW - clinical aspects
KW - food supplements
KW - lungs
KW - metal working fluids
KW - occupational hazards
KW - pneumonitis
KW - respiratory diseases
KW - vitamin E
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - clinical picture
KW - lung diseases
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033039629&site=ehost-live&scope=site
UR - email: ats1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicokinetics of riddelliine, a carcinogenic pyrrolizidine alkaloid, and metabolites in rats and mice.
AU - Williams, L.
AU - Chou, M. W.
AU - Yan, J.
AU - Young, J. F.
AU - Chan, P. C.
AU - Doerge, D. R.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2002///
VL - 182
IS - 2
SP - 98
EP - 104
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Williams, L.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023158785. Publication Type: Journal Article. Language: English. Subject Subsets: Weeds
N2 - The toxicokinetics of riddelliine and 2 metabolites, N-oxide and retronecine, was determined in serum after the administration of riddelliine via oral gavage in male and female rats and mice. Riddolline bioassay results showed that male and female rats and male mice, but not female mice, developed liver tumours. Factors other than toxicokinetics were responsible for the observed species/sex specificity of cross toxicity or liver tumour induction in rats and mice.
KW - animal models
KW - carcinogens
KW - kinetics
KW - liver
KW - metabolites
KW - neoplasms
KW - pyrrolizidine alkaloids
KW - sex
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023158785&site=ehost-live&scope=site
UR - http://www.idealibrary.com/links/doi/10.1006/taap.2002.9441
UR - email: ddoerge@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring.
AU - Hubbs, A. F.
AU - Battelli, L. A.
AU - Goldsmith, W. T.
AU - Porter, D. W.
AU - Frazer, D.
AU - Friend, S.
AU - Schwegler-Berry, D.
AU - Mercer, R. R.
AU - Reynolds, J. S.
AU - Grote, A.
AU - Castranova, V.
AU - Kullman, G.
AU - Fedan, J. S.
AU - Dowdy, J.
AU - Jones, W. G.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2002///
VL - 185
IS - 2
SP - 128
EP - 135
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Hubbs, A. F.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20033138416. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - As the result of a high prevalence of fixed airways obstruction in workers at a microwave popcorn manufacturing plant, we examined the hypothesis that vapors of butter flavoring used in the manufacture of microwave popcorn and other foods can produce airway injury in rats. Rats were exposed to vapors liberated from heated butter flavoring. Rats were exposed for 6 h by inhalation and were necropsied 1 day after exposure. The exposure was found by GC-MS analysis to be a complex mixture of various organic gases with the major peaks consisting of diacetyl (2,3-butanedione), acetic acid, acetoin (3-hydroxy-2-butanone), butyric acid, acetoin dimers, 2-nonanone, and δ-alkyl lactones. Diacetyl was used as a marker of exposure concentration. In the lung, butter flavoring vapors containing 285-371 ppm diacetyl caused multifocal, necrotizing bronchitis, which was most consistently present in the mainstem bronchus. Alveoli were unaffected. Butter flavoring vapors containing 203-371 ppm diacetyl caused necrosuppurative rhinitis, which affected all four levels of the nose. Within the posterior two nasal levels (T3 and T4), necrosis and inflammation was principally localized to the nasopharyngeal duct. Control rats were unaffected. Therefore, concentrations of butter flavoring vapors that can occur during the manufacture of foods are associated with epithelial injury in the nasal passages and pulmonary airways of rats.
KW - animal models
KW - artificial flavours
KW - bronchi
KW - epithelium
KW - flavourings
KW - food processing
KW - inhalation
KW - laboratory animals
KW - necrosis
KW - nose
KW - obstruction
KW - occupational hazards
KW - occupational health
KW - toxicity
KW - trachea
KW - vapour
KW - workers
KW - man
KW - rats
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - artificial flavor
KW - artificial flavors
KW - flavorings
KW - vapor
KW - Food Additives (QQ130)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033138416&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F1 mice.
AU - Howard, P. C.
AU - Couch, L. H.
AU - Patton, R. E.
AU - Eppley, R. M.
AU - Doerge, D. R.
AU - Churchwell, M. I.
AU - Marques, M. M.
AU - Okerberg, C. V.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2002///
VL - 185
IS - 3
SP - 153
EP - 165
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Howard, P. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033048438. Publication Type: Journal Article. Language: English. Registry Number: 9001-78-9, 57-88-5, 123-78-4. Subject Subsets: Medical & Veterinary Mycology
N2 - Fumonisin mycotoxins are produced by Fusaria fungi that grow worldwide primarily on corn. Fumonisin B1, the most predominant form in corn samples, is a renal carcinogen in male F344/N rats and a hepatocarcinogen in female B6C3F1 mice when fed at concentrations higher than 50 ppm (70 µmol/kg) in the diet for 2 years. We sought to determine the relative toxicities of several naturally occurring fumonisin derivatives when included in the diet of female B6C3F1 mice. Mice were fed diets containing fumonisin B1, fumonisin B2, fumonisin B3, fumonisin P1, hydrolyzed-fumonisin B1, N-(acetyl)fumonisin B1, or N-(carboxymethyl)fumonisin B1 (approximately 0, 14, 70, and 140 µmol/kg diet) for 28 days. None of the doses used caused a decrease in body weight gain over the 28 days. Serum levels of total bile acids, cholesterol, and alkaline phosphatase were increased only in mice receiving 72 and 143 µmol/kg fumonisin B1, suggesting that only fumonisin B1 was hepatotoxic in the mice. Corroborating this observation, the liver weight, relative to body weight, was decreased only in the mice that consumed 143 µmol/kg fumonisin B1. Consistent with fumonisin B1 inhibition of ceramide synthase, the liver sphinganine-to-sphingosine ratio was increased and the liver ceramide levels were decreased only in the mice receiving 72 and 143 µmol/kg fumonisin B1. Increased hepatocellular apoptosis, hepatocellular hypertrophy, Kupffer cell hyperplasia, and macrophage pigmentation were detected in the mice consuming 72 and 143 µmol/kg fumonisin B1. The other fumonisin derivatives did not alter serum analytes, organ weights, or hepatic structure. These results suggest that, of the naturally occurring fumonisins, fumonisin B1 is the principal hepatotoxic derivative in the B6C3F1 mouse.
KW - alkaline phosphatase
KW - animal models
KW - apoptosis
KW - bile acids
KW - blood serum
KW - body weight
KW - cholesterol
KW - fumonisins
KW - hyperplasia
KW - hypertrophy
KW - laboratory animals
KW - macrophages
KW - sphingosine
KW - toxicity
KW - weight gain
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alkaline phosphomonoesterase
KW - ceramide
KW - sphinganine
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033048438&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-47G34FR-1&_user=10&_handle=W-WA-A-A-AW-MsSAYVA-UUW-AUVEWAUDYU-DDBCUEUCV-AW-U&_fmt=summary&_coverDate=12%2F15%2F2002&_rdoc=1&_orig=browse&_srch=%23toc%237159%232002%23998149996%23372024!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d2fbd1faa3930d8f5650cd23ea2ab53c
UR - email: Phoward@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood.
AU - Chaisavaneeyakorn, S.
AU - Moore, J. M.
AU - Othoro, C.
AU - Otieno, J.
AU - Chaiyaroj, S. C.
AU - Shi, Y. P.
AU - Nahlen, B. L.
AU - Lal, A. A.
AU - Udhayakumar, V.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2002///
VL - 186
IS - 9
SP - 1371
EP - 1375
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Chaisavaneeyakorn, S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20023186019. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2 - Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids. The present study investigated whether plasma MIF levels are altered in pregnant women from Kenya with placental malaria (PM) and/or human immunodeficiency virus (HIV) infection. For the first time it is demonstrated that MIF levels in the intervillous blood (IVB) plasma were significantly elevated, compared with that in both peripheral plasma (~500-fold) and cord plasma (4.6-fold; P<0.01). IVB mononuclear cells also produced significantly higher levels of MIF, compared with that of peripheral blood mononuclear cells. PM was associated with increased levels of MIF in the IVB plasma (P<0.02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P<0.05). HIV infection did not significantly alter MIF levels in any site examined.
KW - cord blood
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - immunity
KW - macrophages
KW - malaria
KW - maternal transmission
KW - placenta
KW - pregnancy
KW - women
KW - Kenya
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - gestation
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunity reactions
KW - immunological reactions
KW - mother to child transmission
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023186019&site=ehost-live&scope=site
UR - email: vxu0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
AU - Pogribny, I. P.
AU - James, S. J.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002///
VL - 187
IS - 1/2
SP - 69
EP - 75
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0304-3835
AD - Pogribny, I. P.: Division of Biochemical Toxicology, Federal Drug Administration, National Center for Toxicological Research, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023175346. Publication Type: Journal Article. Language: English. Registry Number: 62-49-7, 59-30-3, 63-68-3. Subject Subsets: Public Health; Human Nutrition
N2 - Previous studies have established that chronic dietary insufficiency of the lipotropic nutrients choline and methionine with or without chemical initiation is hepatocarcinogenic in the rat and certain mouse strains. In the present study, the folate/methyl-deficient model of multistage hepatocarcinogenesis was used to evaluate progressive in vivo changes in p16 promoter methylation in both preneoplastic and tumor tissues. Previous studies using this model have demonstrated stage-dependent alterations in genome-wide and p53 gene-specific methylation. In the present study, we used highly sensitive methylation specific PCR (MSP) to determine time of appearance of methylated sequences within p16 promoter. In addition, methylation-sensitive single nucleotide primer extension methodology was applied to determine methylation status of the remaining CpG sites within amplified methylated alleles. Using this approach, extensive methylation in p16 promoter was found in 100% of tumors, but the pattern of methylation varied depending on tumor type. The incidence and extent of de novo methylation in the CpG island of the p16 promoter increased with tumor progression. To further explore the evolution of p16 gene hypermethylation, we examined the appearance and progression of site-specific de novo methylation during early preneoplasia. Our data show that site-specific de novo methylation of 5′ CpG island of p16 gene precedes tumor development and undergoes dynamic expansion during tumor progression.
KW - alleles
KW - animal models
KW - carcinogenesis
KW - carcinogens
KW - choline
KW - folic acid
KW - genes
KW - genomes
KW - human diseases
KW - lipotropic factors
KW - liver
KW - methionine
KW - methylation
KW - neoplasms
KW - nucleotides
KW - nutrient deficiencies
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - folacin
KW - folate
KW - lipotropes
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023175346&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-46VBBNX-C&_user=10&_coverDate=12%2F10%2F2002&_rdoc=10&_fmt=summary&_orig=browse&_srch=%23toc%234992%232002%23998129998%23343810!&_cdi=4992&_sort=d&_docanchor=&wchp=dGLbVlz-lSzBk&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dfcedc67d3a76902d5a3a3424e90fbe4
UR - email: ipogribny@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Idiotypes expressed early in experimental Schistosoma mansoni infections predict clinical outcomes of chronic disease.
AU - Montesano, M. A.
AU - Colley, D. G.
AU - Willard, M. T.
AU - Freeman, G. L., Jr.
AU - Secor, W. E.
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
Y1 - 2002///
VL - 195
IS - 9
SP - 1223
EP - 1228
CY - New York; USA
PB - Rockefeller University Press
SN - 0022-1007
AD - Montesano, M. A.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20023083242. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Helminthology
N2 - In murine S. mansoni infections, schistosome-specific cross-reactive idiotypes (CRI) are present in the sera of mice with moderate splenomegaly syndrome (MSS) at 20 weeks after infection. In contrast, sera from animals that have the more severe hypersplenomegaly syndrome (HSS) at 20 weeks of infection do not express these CRI in their sera. To examine when these regulatory CRI first appear in mice that eventually develop MSS, sera from infected animals were monitored for CRI from 1.5 to 20 weeks of infection. In mice that eventually developed MSS, CRI were detected by 5 to 6 weeks after infection, plateaued by 8 to 10 weeks, and persisted through 20 weeks of infection. Animals that developed HSS pathology or that died before the 20th week of infection never expressed CRI. Moreover, CRI levels present in the sera of mice at 6 weeks postinfection were inversely correlated with splenomegaly and hepatic fibrosis, but not with parasitological measures, at 20 weeks after infection. These results suggest that critical events occur very early in some schistosome infections that induce the production of regulatory idiotypes and that the presence or absence of these idiotypes predicts, and possibly determines, subsequent morbidity.
KW - disease models
KW - experimental infections
KW - hepatic fibrosis
KW - human diseases
KW - idiotypes
KW - laboratory animals
KW - schistosomiasis
KW - splenomegaly
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - schistosomosis
KW - Strigeida
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023083242&site=ehost-live&scope=site
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of United States outbreak isolates of Vibrio parahaemolyticus using enterobacterial repetitive intergenic consensus (ERIC) PCR and development of a rapid PCR method for detection of O3:K6 isolates.
AU - Khan, A. A.
AU - McCarthy, S.
AU - Wang, R. F.
AU - Cerniglia, C. E.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002///
VL - 206
IS - 2
SP - 209
EP - 214
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-1097
AD - Khan, A. A.: Division of Microbiology, US Food and Drug Administration, NCTR, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023034706. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - Outbreaks of Vibrio parahaemolyticus gastroenteritis in the United States (Texas, New York and Pacific Northwest) in 1997-98 emphasized the need to develop molecular methods for identification and differentiation of these organisms. When outbreak isolates were analysed for the enterobacterial repetitive intergenic consensus sequences, the Texas and New York outbreak isolates had a specific 850-bp DNA fragment that was absent in Pacific Northwest isolates. The 850-bp polymerase chain reaction (PCR) product was found in isolates of serovar O3:K6, which have an unusual potential to spread and cause infections. To develop a specific molecular detection method for serovar O3:K6, the nucleotide sequence of the 850-bp product was determined. The GenBank blast analysis did not show homology with any known Vibrio spp. gene sequences. Two PCR primers were designed to specifically amplify the unique sequences from serovar O3:K6 isolates. Genomic DNA from 10 Texas, eight New York, and seven Pacific Northwest outbreak isolates of V. parahaemolyticus was assayed by PCR. Texas and New York isolates were positive in the PCR assay, giving a 327-bp PCR product as predicted; however, Pacific Northwest isolates were negative, indicating the absence of the target gene. Texas and New York isolates were all serovar O3:K6; the Pacific Northwest isolates were not. The primers were tested with other Vibrio spp. and other closely related species and no amplification of the 327-bp PCR product was found. The PCR method can be used to specifically identify O3:K6 V. parahaemolyticus isolates in less than 6 h. The GenBank accession number for the nucleotide sequence data is AF405546.
KW - gastroenteritis
KW - genes
KW - human diseases
KW - molecular epidemiology
KW - nucleotide sequences
KW - outbreaks
KW - serovars
KW - New York
KW - Texas
KW - USA
KW - Vibrio
KW - Vibrio parahaemolyticus
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Vibrio
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - bacterium
KW - DNA sequences
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023034706&site=ehost-live&scope=site
UR - email: akhan@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples.
AU - Wang, R. F.
AU - Beggs, M. L.
AU - Robertson, L. H.
AU - Cerniglia, C. E.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002///
VL - 213
IS - 2
SP - 175
EP - 182
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-1097
AD - Wang, R. F.: Microbiology Division, National Center for Toxicological Research, US-FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023133061. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - An oligonucleotide-microarray method was developed for the detection of intestinal bacteria in fecal samples collected from human subjects. The 16S rDNA sequences of 20 predominant human intestinal bacterial species were used to design oligonucleotide probes. Three 40-mer oligonucleotides specific for each bacterial species (total 60 probes) were synthesized and applied to glass slides. Cyanine5 (CY5)-labeled 16S rDNAs were amplified by polymerase chain reaction (PCR) from human fecal samples or bacterial DNA using two universal primers and were hybridized to the oligo-microarray. The 20 intestinal bacterial species tested were Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides fragilis, Bacteroides distasonis, Clostridium clostridiiforme, Clostridium leptum, Fusobacterium prausnitzii, Peptostreptococcus productus, Ruminococcus obeum, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus albus, Bifidobacterium longum, Bifidobacterium adolescentis, Bifidobacterium infantis, Eubacterium biforme, Eubacterium aerofaciens, Lactobacillus acidophilus, Escherichia coli, and Enterococcus faecium. The two universal primers were able to amplify full size 16S rDNA from all of the 20 bacterial species tested. The hybridization results indicated that the oligo-microarray method developed in this study is a reliable method for the detection of predominant human intestinal bacteria in the fecal samples.
KW - analytical methods
KW - bacterial diseases
KW - design
KW - evaluation
KW - faeces
KW - human diseases
KW - intestinal microorganisms
KW - nucleotide sequences
KW - oligonucleotides
KW - polymerase chain reaction
KW - Bacteroides
KW - Bacteroides fragilis
KW - Bacteroides thetaiotaomicron
KW - Bacteroides vulgatus
KW - Bifidobacterium adolescentis
KW - Bifidobacterium longum
KW - Clostridium
KW - Clostridium leptum
KW - Collinsella aerofaciens
KW - Enterococcus faecium
KW - Escherichia coli
KW - Eubacterium
KW - Eubacterium biforme
KW - Faecalibacterium prausnitzii
KW - Fusobacterium
KW - Lactobacillus acidophilus
KW - Parabacteroides distasonis
KW - Peptostreptococcus
KW - Ruminococcus
KW - Ruminococcus albus
KW - Ruminococcus bromii
KW - Ruminococcus callidus
KW - Ruminococcus obeum
KW - Ruminococcus productus
KW - Bacteroidaceae
KW - Bacteroidales
KW - Bacteroidetes (class)
KW - Bacteroidetes (phylum)
KW - Bacteria
KW - prokaryotes
KW - Bacteroides
KW - Bifidobacterium
KW - Bifidobacteriaceae
KW - Bifidobacteriales
KW - Actinobacteridae
KW - Actinobacteria
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Eubacteriaceae
KW - Fusobacteriaceae
KW - Fusobacteriales
KW - Fusobacteria
KW - Lactobacillus
KW - Lactobacillaceae
KW - Peptostreptococcaceae
KW - Lachnospiraceae
KW - Ruminococcus
KW - Clostridium
KW - Eubacterium
KW - Parabacteroides
KW - Porphyromonadaceae
KW - Collinsella
KW - Coriobacteriaceae
KW - Coriobacterineae
KW - Coriobacteriales
KW - Coriobacteridae
KW - Faecalibacterium
KW - analytical techniques
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Bacteroides distasonis
KW - Bifidobacterium infantis
KW - Clostridium clostridiiforme
KW - DNA sequences
KW - E. coli
KW - Eubacterium aerofaciens
KW - feces
KW - Fusobacterium prausnitzii
KW - gut flora
KW - intestinal micro-organisms
KW - PCR
KW - Peptostreptococcus productus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023133061&site=ehost-live&scope=site
UR - email: rwang@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of growth media on vancomycin resistance of Enterococcus isolates and correlation with resistance gene determinants.
AU - Nayak, R.
AU - Khan, S. A.
AU - Watson, R. H.
AU - Cerniglia, C. E.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002///
VL - 214
IS - 2
SP - 159
EP - 163
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-1097
AD - Nayak, R.: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023157589. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 1404-90-6, 1404-93-9. Subject Subsets: Public Health
N2 - The effect of Mueller-Hinton (MH), MH+blood or brain heart infusion medium (agar or broth) on the antibiotic susceptibility of 13 Enterococcus isolates was determined. Disk diffusion and Vitek methods were used to determine vancomycin resistance, while broth dilution and E-test methods were used to measure the minimum inhibitory concentration. The data were correlated with the presence of vancomycin resistance genes. A definite correlation pattern could not be established between the presence of van genes and vancomycin resistance in any plating medium, when tested by the disk diffusion assay. The broth dilution, irrespective of the plating medium, and Vitek methods were more reliable than the E-test method in testing isolates with vanA or vanB genes. However, for vanC2/C3 genotypes, the E-test method, irrespective of the plating medium, tested better than the broth dilution assay.
KW - antibacterial agents
KW - culture media
KW - drug resistance
KW - genes
KW - vancomycin
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157589&site=ehost-live&scope=site
UR - email: skhan@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemoprotection by phenolic antioxidants: inhibition of tumor necrosis factor α induction in macrophages.
AU - Ma, Q.
AU - Kinneer, K.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2002///
VL - 277
IS - 4
SP - 2477
EP - 2484
CY - Birmingham; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Ma, Q.: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023035545. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 123-31-9, 308079-78-9. Subject Subsets: Human Nutrition
N2 - Phenolic antioxidants exhibit antiinflammatory activity in protection against chemical toxicity and cancer. To investigate the molecular mechanism of antiinflammation, we analysed the regulation of tumour necrosis factor-α (TNF-α) expression in macrophages (mouse monocyte-macrophage RAW 264.7 cell line), a key step in inflammation, by the antioxidants. Whereas lipopolysaccharide (LPS), an inflammatory inducer, stimulated the rapid synthesis of TNF-α protein, phenolic antioxidants, exemplified by tert-butyl hydroquinone and 1,4-dihydroquinone, blocked LPS-induced production of TNF-α protein in a time- and dose-dependent manner. Inhibition of TNF-α induction correlated with the capacity of the antioxidants to undergo oxidation-reduction cycling, implicating oxidative signalling in the inhibition. The antioxidants blocked LPS-induced increase of the steady-state mRNA of TNF-α but did not affect the half-life of the mRNA. Electrophoretic mobility shift assay revealed a total inhibition of LPS-induced formation of nuclear factor κB-DNA binding complexes by phenolic antioxidants. Finally, 1,4-dihydroquinone blocked the induction of TNF-α target genes interleukin 1β and interleukin 6 at both mRNA and protein levels. Our findings demonstrate that phenolic antioxidants potently inhibit signal-induced TNF-α transcription, and suggest a mechanism of antiinflammation by the antioxidants through control of cytokine induction during inflammation.
KW - antiinflammatory properties
KW - antioxidants
KW - cytokines
KW - gene expression
KW - genes
KW - hydroquinone
KW - inflammation
KW - inhibition
KW - interleukin 1
KW - interleukin 6
KW - lipopolysaccharides
KW - macrophages
KW - messenger RNA
KW - phenols
KW - redox reactions
KW - transcription
KW - tumour necrosis factor
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 1,4-dihydroquinone
KW - anti-inflammatory properties
KW - cachectin
KW - cachexin
KW - DNA transcription
KW - mRNA
KW - oxidation reduction reactions
KW - tert-butyl hydroquinone
KW - tumor necrosis factor
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023035545&site=ehost-live&scope=site
UR - email: qam1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effects of socioeconomic status on health in rural and urban America.
AU - Blumenthal, S. J.
AU - Kagen, J.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2002///
VL - 287
IS - 1
SP - 109
EP - 109
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Blumenthal, S. J.: US Department of Health and Human Services, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20023007839. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health
KW - access
KW - community health
KW - education
KW - ethnicity
KW - health care
KW - health insurance
KW - health services
KW - life expectancy
KW - low income
KW - mortality
KW - poverty
KW - public health
KW - risk
KW - risk factors
KW - rural areas
KW - socioeconomic status
KW - socioeconomics
KW - urban areas
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - ethnic differences
KW - socioeconomic aspects
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Income and Poverty (EE950)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023007839&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control.
AU - Amexis, G.
AU - Rubin, S.
AU - Chizhikov, V.
AU - Pelloquin, F.
AU - Carbone, K.
AU - Chumakov, K.
JO - Virology
JF - Virology
Y1 - 2002///
VL - 300
IS - 2
SP - 171
EP - 179
CY - Orlando; USA
PB - Academic Press
SN - 0042-6822
AD - Amexis, G.: Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike HFM-470, Rockville, MD 20852, USA.
N1 - Accession Number: 20023161179. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - The Jeryl Lynn strain of mumps vaccine live (MVL) was developed in 1966 by Merck Co. and has been widely used in the USA and other countries since the early 1970s. Partial sequencing has recently shown that the vaccine contains a mixture of two substrains with substantially different nucleotide sequences. We have determined the complete genomic sequences of both substrains and identified 414 nucleotide differences (2.69%), leading to 87 amino acid substitutions (1.67%). We used this information to develop methods for quantification of the substrain components in vaccine samples based on PCR and restriction enzyme cleavage and oligonucleotide microarray hybridization and monitored their dynamics in viral populations propagated in different conditions. Passaging Jeryl Lynn strain in Vero or CEF cell cultures resulted in rapid selection of the major component JL1, while growth in embryonated chicken eggs (ECE) favoured accumulation of the minor component JL2. Based on the findings presented here, it is proposed that the substrain composition of Jeryl Lynn vaccine can be monitored as a part of its quality control to ensure consistency of the vaccine.
KW - amino acid sequences
KW - genome analysis
KW - mumps
KW - mutants
KW - nucleotide sequences
KW - quality controls
KW - vaccine development
KW - vaccines
KW - USA
KW - mumps virus
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - DNA sequences
KW - protein sequences
KW - quality assurance
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023161179&site=ehost-live&scope=site
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.
AU - Kreiss, K.
AU - Gomaa, A.
AU - Kullman, G.
AU - Fedan, K.
AU - Simoes, E. J.
AU - Enright, P. L.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2002///
VL - 347
IS - 5
SP - 330
EP - 338
CY - Waltham; USA
PB - Massachusetts Medical Society
SN - 0028-4793
AD - Kreiss, K.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, H2800, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20023117923. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 431-03-8. Subject Subsets: Public Health
N2 - Background: In May 2000, eight persons who had formerly worked at a microwave-popcorn production plant in Missouri, USA, were reported to have severe bronchiolitis obliterans. No recognized cause was identified in the plant. Therefore, we medically evaluated current employees and assessed their occupational exposures. Methods: Questionnaire responses and spirometric findings in participating workers were compared with data from the third National Health and Nutrition Examination Survey, after adjustment for age and smoking status. We evaluated the relation between exposures and health-related outcomes by analysing the rates of symptoms and abnormalities according to current and cumulative exposure to diacetyl, the predominant ketone in artificial butter flavouring and in the air at the plant. Results: Of the 135 current workers at the plant, 117 (87%) completed the questionnaire. These 117 workers had 2.6 times the expected rates of chronic cough and shortness of breath, according to comparisons with the national data, and twice the expected rates of physician-diagnosed asthma and chronic bronchitis. Overall, the workers had 3.3 times the expected rate of airway obstruction; those who had never smoked had 10.8 times the expected rate. Workers directly involved in the production of microwave popcorn had higher rates of shortness of breath on exertion and skin problems that had developed since they started work than workers in other parts of the plant. There was a strong relation between the quartile of estimated cumulative exposure to diacetyl and the frequency and extent of airway obstruction. Conclusions: The excess rates of lung disease and lung-function abnormalities and the relation between exposure and outcomes in this working population indicate that they probably have occupational bronchiolitis obliterans caused by the inhalation of volatile butter-flavouring ingredients.
KW - asthma
KW - bronchitis
KW - cough
KW - diacetyl
KW - dyspnoea
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - respiratory diseases
KW - Missouri
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - bronchiolitis obliterans
KW - dyspnea
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023117923&site=ehost-live&scope=site
UR - email: kkreiss@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV-1 infection and risk of vulvovaginal and perianal condylomata acuminata and intraepithelial neoplasia: a prospective cohort study.
AU - Conley, L. J.
AU - Ellerbrock, T. V.
AU - Bush, T. J.
AU - Chiasson, M. A.
AU - Sawo, D.
AU - Wright, T. C.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 2002///
VL - 359
IS - 9301
SP - 108
EP - 113
CY - London; UK
PB - Lancet Limited
SN - 0140-6736
AD - Conley, L. J.: Division of HIV/AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20023008775. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Background: Information about vulvovaginal and perianal condylomata acuminata and intraepithelial neoplasia in HIV-1-infected women is needed to develop guidelines for clinical care. Our aim was to investigate the incidence of these lesions in HIV-1-positive and HIV-1-negative women, and to examine risk factors for disease. Methods: In a prospective cohort study (October 1991-September 1998), 925 women from New York, USA had a gynaecological examination twice yearly - including colposcopy and tests for human papillomavirus DNA in cervicovaginal lavage - for a median follow-up of 3.2 years (IQR, 0.98-4.87). Findings: Vulvovaginal and perianal condylomata acuminata or intraepithelial neoplasia were present in 30 (6%) of 481 HIV-1-positive and 4 (1%) of 437 HIV-1-negative women (P<0.0001) at enrollment. Women without lesions at enrollment were included in an incidence analysis. 33 (9%) of 385 HIV-1-positive and 2 (1%) of 341 HIV-1-negative women developed vulvovaginal or perianal lesions, resulting in an incidence of 2.6 and 0.16 cases per 100 person-years, respectively (relative risk, 16; 95% confidence interval, 12.9-20.5; P<0.0001). Risk factors for incident lesions included HIV-1 infection (P=0.013), human papillomavirus infection (P=0.0013), lower CD4+ lymphocyte count (P=0.0395), and history of frequent injection of drugs (P=0.0199). Interpretation: Our results suggest that HIV-1-positive women are at increased risk of developing invasive vulvar carcinoma. Thus, we recommend that, as part of every gynaecological examination, HIV-1-positive women should have a thorough inspection of the vulva and perianal region, and women with abnormalities - except for typical, exophytic condylomata acuminata - should undergo colposcopy and biopsy.
KW - anus
KW - CD4+ lymphocytes
KW - condyloma acuminatum
KW - genital ulcers
KW - HIV-1 infections
KW - human diseases
KW - immunocompromised hosts
KW - injecting drug abuse
KW - neoplasms
KW - opportunistic infections
KW - risk factors
KW - vagina
KW - viral diseases
KW - vulva
KW - women
KW - New York
KW - USA
KW - Human immunodeficiency virus 1
KW - human papillomaviruses
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Papillomavirus
KW - dsDNA viruses
KW - DNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Papillomaviridae
KW - cancers
KW - CD4+ cells
KW - human immunodeficiency virus type 1
KW - human papillomavirus
KW - i.v. drug abuse
KW - i.v. drug use
KW - Papovaviridae
KW - T4 lymphocytes
KW - United States of America
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023008775&site=ehost-live&scope=site
UR - email: tcw1@columbia.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chromatographic separation and identification of conjugated linoleic acid isomers.
AU - Roach, J. A. G.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2002///
VL - 465
IS - 1/2
SP - 207
EP - 226
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0003-2670
AD - Roach, J. A. G.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20023171488. Publication Type: Journal Article. Language: English. Registry Number: 60-33-3. Subject Subsets: Human Nutrition
N2 - There are 56 possible geometric and positional isomers of conjugated octadecadienoic acids (18:2), better known as conjugated linoleic acid (CLA). Positive health benefits are ascribed to the consumption of the 9c,11t-18:2 and 10t,12c-18:2 isomers. The dietary significance of the other isomers is not known. Our understanding of the biological role of these acids relies on their proper identification and quantitation in complex biological extracts. Gas chromatography (GC) alone cannot completely separate the naturally occurring CLA isomers. The combination of silver ion high performance liquid chromatography (Ag+ HPLC) and GC offers the best separation of these isomers with complementary identification by GC-mass spectrometry (GC-MS) and GC-Fourier transform infrared (FTIR) analyses.
KW - analytical methods
KW - food chemistry
KW - gas chromatography
KW - HPLC
KW - isomers
KW - linoleic acid
KW - separation
KW - analytical techniques
KW - high performance liquid chromatography
KW - separating
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023171488&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-45HWR71-1&_user=10&_coverDate=08%2F16%2F2002&_rdoc=14&_fmt=summary&_orig=browse&_srch=%23toc%235216%232002%23995349998%23327752!&_cdi=5216&_sort=d&_docanchor=&wchp=dGLbVlz-lSztA&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3c819897cc24cc3f30deb8940e6353c7
UR - email: magdi.mossoba@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity.
AU - Johnson, E. A.
AU - Shvedova, A. A.
AU - Kisin, E.
AU - O'Callaghan, J. P.
AU - Kommineni, C.
AU - Miller, D. B.
JO - Brain Research
JF - Brain Research
Y1 - 2002///
VL - 933
IS - 2
SP - 150
EP - 163
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V, Biomedical Division
SN - 0006-8993
AD - Johnson, E. A.: Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health/Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20023172139. Publication Type: Journal Article. Language: English. Registry Number: 51-61-6, 70-18-8, 1406-18-4. Subject Subsets: Human Nutrition
N2 - The mechanism of 3,4-methylenedioxymethamphetamine (d-MDMA)-induced neurotoxicity may involve formation of toxic radical species. Endogenous defenses against toxic radical species include tissue stores of vitamin E, and thiols. We examined whether vitamin E deficiency could alter d-MDMA-induced neurotoxicity by administration of the drug to animals with diet induced vitamin E deficiency. Brain vitamin E levels in deficient mice were reduced 75% compared to sufficient animals. Animals received d-MDMA 5 or 10 mg/kg or saline (delivered every 2 h × 4, s.c.). Diet slightly altered d-MDMA-induced temperature modulation. In brain, MDMA treatment reduced vitamin E, total antioxidant reserve and protein thiols 72 h after the first dose. In liver, MDMA treatment reduced glutathione and total antioxidant reserve at the same time point. The vitamin E-deficient group, treated with the low dose of d-MDMA, exhibited neurotoxic responses, including reduced striatal dopamine (47%) and elevated GFAP protein (3-fold): while the sufficient diet group was not altered. The higher d-MDMA dose caused neurotoxic responses in both diet groups. Liver toxicity was determined by histopathologic examination. d-MDMA caused hepatic necrosis that was more severe in vitamin E deficient than sufficient mice. These data indicate that (1) d-MDMA administration reduces antioxidant measures at a time coincident with d-MDMA-induced neuronal damage and (2) vitamin E deficiency increases susceptibility to d-MDMA-induced neurotoxicity and hepatic necrosis.
KW - animal models
KW - antioxidants
KW - brain
KW - dopamine
KW - glutathione
KW - liver
KW - neurotoxicity
KW - thiols
KW - vitamin deficiencies
KW - vitamin E
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 3,4-methylenedioxymethamphetamine
KW - cerebrum
KW - hepatotoxicity
KW - mercaptans
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023172139&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-45519B1-1&_user=10&_coverDate=04%2F19%2F2002&_rdoc=8&_fmt=summary&_orig=browse&_srch=%23toc%234841%232002%23990669997%23298375!&_cdi=4841&_sort=d&_docanchor=&wchp=dGLbVzb-lSzBV&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=acf82320180c44cbf0c45376540b7f57
UR - email: edj2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.
AU - Sweeney, C.
AU - Coles, B. F.
AU - Nowell, S.
AU - Lang, N. P.
AU - Kadlubar, F. F.
JO - Toxicology
JF - Toxicology
Y1 - 2002///
VL - 181/182
SP - 83
EP - 87
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0300-483X
AD - Sweeney, C.: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033035568. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2. Subject Subsets: Public Health; Human Nutrition
N2 - Red meats cooked at high temperatures generate mutagenic heterocyclic amines, which undergo metabolic activation by hepatic cytochrome P450 1A2 and N-acetyltransferase-2. A primary detoxification pathway involves glutathione S-transferase A1 (GSTA1), which catalyzes the reduction of the carcinogenic N-acetoxy derivative back to the parent amine. Recently, we described a polymorphism in the GSTA1 proximal promoter; the variant (GSTA1*B) allele significantly lowers enzyme expression. In a case-control study, GSTA1*B/*B genotype was associated with an increased risk of colorectal cancer, particularly among consumers of well-done meat. Dietary nitrosamines, which are bioactivated by CYP2A6, represent another potential etiologic factor for colorectal cancer. CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay. The distribution of CYP2A6 activity was significantly different between CRCa cases and controls, with subjects in the medium and high activity groups having an increased risk (P for TREND=0.001). GSTA1 genotype and CYP2A6 phenotype should be evaluated as markers of susceptibility to dietary carcinogens in future studies.
KW - carcinogens
KW - colorectal cancer
KW - cooking
KW - cytochrome P-450
KW - diets
KW - genetic polymorphism
KW - human diseases
KW - markers
KW - meat
KW - neoplasms
KW - nitrosamines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033035568&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=Articleurl&_udi=b6tcn-4691mpr-1&_user=10&_handle=w-wa-a-a-ee-mssayvw-uua-auvywwbdec-bcczzducw-ee-u&_fmt=summary&_coverdate=12%2f27%2f2002&_rdoc=14&_orig=browse&_srch=%23toc%235175%232002%23998189999%23373302!&_cdi=5175&view=c&_acct=C000050221&_version=1&_urlversion=0&_userid=10&md5=703fae92d4c07e39f11d132448766958
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current developments in food additive toxicology in the USA.
AU - Hattan, D. G.
AU - Kahl, L. S.
JO - Toxicology
JF - Toxicology
Y1 - 2002///
VL - 181/182
SP - 417
EP - 420
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0300-483X
AD - Hattan, D. G.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C. St., S.W., Washington, DC 20204, USA.
N1 - Accession Number: 20033035561. Publication Type: Journal Article. Language: English. Subject Subsets: Agricultural Biotechnology
N2 - A recently published proposal (Fed. Reg. 66 (2001) 4706) for mandatory submission of information on all plant-derived bioengineered foods fed to humans or animals will be reviewed. Under this proposal, information such as data on identity, level and function of the introduced substance(s); an estimate of dietary exposure; allergenic potential of the protein; data relevant to other safety issues that may be associated with the substance; selection of a comparable food; historic uses of comparable food; composition and characteristics of bioengineered food versus those of the comparable food should be provided. In addition, characterization of the parent plant; construction of the transformation vector and introduced genetic material along with number of insertion sites and genes; data on the genetic material and any newly inserted genes for antibiotic resistance should be submitted with the notification. The Interagency Coordinating Committee for Validation of Alternative Methods (ICCVAM) was identified by the U.S. Congress as the organization to review and validate new alternative toxicological test methods for 14 U.S. government agencies. Validated and accepted alternative toxicity tests will be incorporated into toxicity testing recommendations for regulatory agencies.
KW - analytical methods
KW - biotechnology
KW - food additives
KW - food safety
KW - toxicology
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - United States of America
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033035561&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-47189VB-1&_user=10&_handle=W-WA-A-A-EE-MsSAYVW-UUA-AUVYWWBDEC-BCCZZDUCW-EE-U&_fmt=summary&_coverDate=12%2F27%2F2002&_rdoc=70&_orig=browse&_srch=%23toc%235175%232002%23998189999%23373302!&_cdi=5175&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7629316d9e4f6c319a3d13e2c0c16c15
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.
AU - Culp, S. J.
AU - Beland, F. A.
AU - Heflich, R. H.
AU - Benson, R. W.
AU - Blankenship, L. R.
AU - Webb, P. J.
AU - Mellick, P. W.
AU - Trotter, R. W.
AU - Shelton, S. D.
AU - Greenlees, K. J.
AU - Manjanatha, M. G.
A2 - Snyderwine, E. G.
A2 - Sinha, R.
A2 - Ferguson, L. R.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2002///
VL - 506/507
IS - Special Issue
SP - 55
EP - 63
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0027-5107
AD - Culp, S. J.: Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20023165912. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Leucomalachite green is a persistent and prevalent metabolite of malachite green, a triphenylmethane dye that has been used widely as an antifungal agent in the fish industry. Concern over the use of malachite green is due to the potential for consumer exposure, evidence suggestive of tumour promotion in rodent liver, and suspicion of carcinogenicity based on structure-activity relationships. Our previous study indicated that feeding rodents malachite or leucomalachite green resulted in a dose-related increase in liver DNA adducts, and that, in general, exposure to leucomalachite green caused an increase in the number and severity of changes greater than was observed following exposure to malachite green. To characterize better the genotoxicity of leucomalachite green, female Big Blue rats were fed leucomalachite green at doses of 0, 9, 27, 91, 272, or 543 ppm for up to 32 weeks. The livers were analysed for lacI mutations at 4, 16, and 32 weeks and DNA adducts at 4 weeks. Using a 32P-postlabelling assay, we observed a dose-related DNA adduct in the livers of rats fed 91, 272, and 543 ppm leucomalachite green. A ~3-fold increase in lacI mutant frequency was found in the livers of rats fed 543 ppm leucomalachite green for 16 weeks, but significant increases in mutant frequencies were not found for any of the other doses or time points assayed. We also conducted 2-year tumorigenesis bioassays in female and male F344 rats using 0, 91, 272, and 543 ppm leucomalachite green. Preliminary results indicate an increasing dose trend in lung adenomas in male rats treated with leucomalachite green, but no increase in the incidence of liver tumours in either sex of rat. These results suggest that the DNA adduct formed in the livers of rats fed leucomalachite green has little mutagenic or carcinogenic consequence.
KW - adenoma
KW - animal models
KW - DNA
KW - genotoxicity
KW - human diseases
KW - laboratory animals
KW - liver
KW - metabolites
KW - mutagenicity
KW - mutants
KW - mutations
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - leucomalachite green
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023165912&site=ehost-live&scope=site
UR - email: sculp@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.
AU - Turesky, R. J.
AU - Guengerich, F. P.
AU - Guillouzo, A.
AU - Langouët, S.
A2 - Snyderwine, E. G.
A2 - Sinha, R.
A2 - Ferguson, L. R.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2002///
VL - 506/507
IS - Special Issue
SP - 187
EP - 195
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0027-5107
AD - Turesky, R. J.: National Center for Toxicological Research, 3900 NCTR Dr., HFT 100 Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20023165910. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 21 ref. Registry Number: 9035-51-2. Subject Subsets: Human Nutrition
N2 - The metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was investigated in primary human and rat hepatocytes. The genotoxic metabolites 2-(hydroxyamino)-3,8-dimethylimidazo[4,5-f]quinoxaline (HONH-MeIQx) and 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine (HONH-PhIP), which are formed by cytochrome P4501A2 (CYP1A2), were detected as stable N2-glucuronide and N2- and N3-glucuronide conjugates, respectively. These products accounted for as much as 10% of the amount of MeIQx and 60% of PhIP added to human hepatocytes. Significantly lower amounts of these products were formed in rat hepatocytes. The phase II conjugates N2-(3,8-dimethylimidazo[4,5-f]quinoxalin-2-yl-sulfamic acid) (MeIQx-N2-SO3H) and N2-(β-1-glucosiduronyl)-2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline (MeIQx-N2-G1), as well as the 7-oxo derivatives of MeIQx and N-desmethyl-MeIQx, 2-amino-3,8-dimethyl-6-hydro-7H-imidazo[4,5-f]quinoxalin-7- one (7-oxo-MeIQx), and 2-amino-6-hydro-8-methyl-7H-imidazo[4,5-f]quinoxalin-7-one (N-desmethyl-7-oxo-MeIQx) were also identified. A novel CYP1A2-derived metabolite was characterized as 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid (IQx-8-COOH) and was the predominant metabolite formed in human hepatocytes exposed to MeIQx at levels approaching human exposure. Unlike human hepatocytes, rat cell preparations, even following pretreatment with the potent CYP1A1/CYP1A2 inducer 3-methylcholanthrene (3-MC) did not produce IQx-8-COOH but did catalyse the formation of 2-amino-3,8-dimethyl-5-hydroxyimidazo[4,5-f]quinoxaline (5-HO-MeIQx) as a major CYP-mediated detoxication product. In the case of PhIP, direct glucuronidation of the N2 and N3 positions also occurred in human and rat hepatocytes. Glucuronide and sulfate conjugates of 2-amino-4′-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine (4′-HO-PhIP) were detected as relatively minor metabolites in human hepatocytes but were the major products formed in rat hepatocytes, accounting for up to 50% of the metabolism. Rat CYP1A2, but not the human orthologue, significantly contributes to 4′-hydroxylation of PhIP. Important differences exist between human and rat liver enzymes in catalytic activity and regioselectivity of MeIQx and PhIP metabolism. Some human hepatocyte preparations are more active at transforming MeIQx and PhIP to a genotoxic species than rat hepatocytes pretreated with potent inducer 3-MC. These pronounced interspecies differences in metabolism of MeIQx and PhIP may affect the biological activity of these mutagens and must be considered when assessing human health risk.
KW - animal models
KW - cytochrome P-450
KW - laboratory animals
KW - liver cells
KW - metabolism
KW - metabolites
KW - pyridines
KW - quinoxalines
KW - man
KW - rats
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - hepatocytes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023165910&site=ehost-live&scope=site
UR - email: rturesky@nctr.fda.gov\sophie.langouet@rennes.inserm.fr
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Doramectin.
AU - Chamberlain, P. L.
T2 - WHO Food Additives Series
T3 - Toxicological evaluation of certain veterinary drug residues in food. Prepared by the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives
JO - WHO Food Additives Series
JF - WHO Food Additives Series
Y1 - 2002///
IS - 49
CY - Geneva; Switzerland
PB - World Health Organization
SN - 0300-0923
AD - Chamberlain, P. L.: Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20033005861. Publication Type: Bulletin article. Note: Toxicological evaluation of certain veterinary drug residues in food. Prepared by the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives Language: English. Number of References: 15 ref. Registry Number: 71751-41-2, 117704-25-3, 70288-86-7. Subject Subsets: Public Health; Helminthology; Tropical Diseases; Veterinary Science
N2 - Information on the toxicity of doramectin and other avermectins is reviewed, including the mechanism of toxicity in dogs and cattle and relative sensitivities of mice, rats, rabbits, dogs and non-human primates to avermectins. The relative potencies of doramectin, ivermectin and abamectin and observations on polymorphisms in the human MDR-1 gene coding for P-glycoprotein, and patients with onchocerciasis and healthy volunteers treated with ivermectin are included. Some comments and an evaluation are given at the end.
KW - abamectin
KW - animal parasitic nematodes
KW - avermectins
KW - doramectin
KW - drug therapy
KW - drug toxicity
KW - genes
KW - genetic polymorphism
KW - glycoproteins
KW - ivermectin
KW - onchocerciasis
KW - pharmacodynamics
KW - pharmacokinetics
KW - potency
KW - reviews
KW - toxicity
KW - cattle
KW - dogs
KW - man
KW - mice
KW - monkeys
KW - Onchocerca
KW - rabbits
KW - rats
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Homo
KW - Hominidae
KW - Primates
KW - Muridae
KW - rodents
KW - Onchocercidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - Leporidae
KW - Lagomorpha
KW - animal-parasitic nematodes
KW - avermectin B1
KW - chemotherapy
KW - drug action
KW - mechanism of drug action
KW - nematode parasites of animals
KW - nematodes
KW - nematodes of animals
KW - onchocercosis
KW - river blindness
KW - Secernentea
KW - Spirurida
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033005861&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The emergence of West Nile virus in North America: ecology, epidemiology and surveillance.
AU - Roehrig, J. T.
AU - Layton, M.
AU - Smith, P.
AU - Campbell, G. L.
AU - Nasci, R.
AU - Lanciotti, R. S.
T3 - Japanese encephalitis and West Nile viruses
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
Y1 - 2002///
IS - 267
SP - 223
EP - 240
CY - Berlin; Germany
PB - Springer-Verlag
SN - 0070-217X
AD - Roehrig, J. T.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, USA.
N1 - Accession Number: 20033051502. Publication Type: Journal Article. Note: Japanese encephalitis and West Nile viruses Language: English. Number of References: many ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - This chapter discusses the arboviral encephalitis in the USA, the West Nile (WN) virus outbreak in New York City and surrounding areas in 1999, and the return of WN virus infection and expanding epizootic in 2000. The genetics of WN virus in North America, its expanding ecology and interactions with other circulating flaviviruses are described. The potential for a large WN encephalitis human epidemic is assessed.
KW - arboviruses
KW - encephalitis
KW - epidemics
KW - epidemiology
KW - genetics
KW - human diseases
KW - microbial ecology
KW - mosquito-borne diseases
KW - outbreaks
KW - surveillance
KW - viral diseases
KW - New York
KW - North America
KW - USA
KW - Flavivirus
KW - man
KW - West Nile virus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - arthropod-borne viruses
KW - encephalomyelitis
KW - United States of America
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbial Ecology (ZZ333) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033051502&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Shigella.
AU - Lampel, K. A.
AU - Maurelli, A. T.
A2 - Cliver, D. O.
A2 - Riemann, H. P.
T2 - Foodborne diseases
Y1 - 2002///
IS - Ed. 2
CY - London; UK
PB - Academic Press
SN - 0121765598
AD - Lampel, K. A.: Food and Drug Administration, HFS-237, 200 C Street SW, Washington, DC 20204, USA.
N1 - Accession Number: 20033051860. Publication Type: Book chapter. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Veterinary Science; Public Health
N2 - This chapter describes the taxonomy, growth and survival of Shigella spp., and discusses the clinical features, pathogenesis, foodborne transmission, treatment (e.g., antibiotic therapy) and prevention (e.g., proper hygiene) of shigellosis.
KW - antibacterial agents
KW - antibiotics
KW - clinical aspects
KW - disease prevention
KW - disease transmission
KW - drug therapy
KW - foodborne diseases
KW - growth
KW - human diseases
KW - hygiene
KW - pathogenesis
KW - shigellosis
KW - taxonomy
KW - man
KW - Shigella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - systematics
KW - Environmental Pest Management (HH200)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033051860&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Methods for trans fatty acid analysis.
AU - McDonald, R. E.
AU - Mossoba, M. M.
A2 - Akoh, C. C.
A2 - Min, D. B.
T2 - Food lipids: chemistry, nutrition, and biotechnology
Y1 - 2002///
IS - Ed.2
CY - New York; USA
PB - Marcel Dekker
SN - 0824707494
AD - McDonald, R. E.: Division of Food Processing and Packaging, National Center for Food Safety and Technology, U.S. Food and Drug Administration, Summit-Argo, Illinois, USA.
N1 - Accession Number: 20053045465. Publication Type: Book chapter. Language: English. Number of References: 156 ref. Subject Subsets: Human Nutrition
N2 - The different analytical methods (spectroscopy, chromatography and combined methods) available to determine and analyse total trans fatty acid contents in food products (specifically hydrogenated oils) are discussed.
KW - analytical methods
KW - chemical composition
KW - chromatography
KW - determination
KW - food
KW - hydrogenated oils
KW - oil products
KW - spectroscopy
KW - trans fatty acids
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053045465&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vaccines against asexual stage malaria parasites.
AU - Kumar, S.
AU - Epstein, J. E.
AU - Richie, T. L.
A2 - Perlmann, P.
A2 - Troye-Blomberg, M.
T2 - Malaria immunology
T3 - Chemical Immunology Vol. 80
Y1 - 2002///
IS - Ed.2
CY - Basel; Switzerland
PB - S Karger AG
SN - 3805573766
AD - Kumar, S.: Section of Bacterial and Parasitic Diseases, Office of Blood Review and Research, DETTD, CBER, HMF-313, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20023100434. Publication Type: Book chapter. Note: Chemical Immunology Vol. 80 Language: English. Number of References: 139 ref. Subject Subsets: Tropical Diseases; Protozoology
KW - developmental stages
KW - human diseases
KW - immunization
KW - malaria
KW - vaccination
KW - vaccine development
KW - vaccines
KW - man
KW - Plasmodium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - growth phase
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023100434&site=ehost-live&scope=site
UR - email: kumarS@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Borna disease virus and its role in neurobehavioral disease.
AU - Carbone, K. M.
A2 - Carbone, K. M.
T2 - Borna disease virus and its role in neurobehavioral disease
Y1 - 2002///
CY - Herndon; USA
PB - ASM Press
SN - 155581235X
AD - Carbone, K. M.: Office of the Director, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, HFM 20, 8800 Wisconsin Ave., Bethesda, MD 20892, USA.
N1 - Accession Number: 20033120866. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - The pathogenesis, diagnosis and epidemiology of Borna diseases in animals (cats, dogs and birds) and humans are discussed. The links between the Borna disease virus and neuropsychiatric diseases in humans are also discussed. This book is aimed at giving new information about this virus to virologists, especially those who are interested in virus-related neuropsychiatric disorders.
KW - diagnosis
KW - epidemiology
KW - human diseases
KW - mental disorders
KW - pathogenesis
KW - birds
KW - borna disease virus
KW - cats
KW - dogs
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bornavirus
KW - Bornaviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - Canis
KW - Canidae
KW - Homo
KW - Hominidae
KW - Primates
KW - mental illness
KW - psychiatric disorders
KW - Pets and Companion Animals (LL070)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033120866&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation of herbal medicines in Nigeria: the role of the National Agency for Food and Drug Administration and Control (NAFDAC).
AU - Osuide, G. E.
A2 - Iwu, M. M.
A2 - Wootton, J. C.
T2 - Ethnomedicine and drug discovery
T3 - Advances in Phytomedicine Vol.1
Y1 - 2002///
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 044450852X
AD - Osuide, G. E.: National Agency for Food and Drug Administration and Control, lot 1057, Ikeja Cresent, Off Oyo Road, Area 2 Section 1, Garki, Abuja, Nigeria.
N1 - Accession Number: 20033109007. Publication Type: Book chapter. Note: Advances in Phytomedicine Vol.1 Language: English. Number of References: 3 ref. Subject Subsets: Rural Development; Horticultural Science; Tropical Diseases; Aromatic & Medicinal Plants
N2 - In most developing countries, including Nigeria, the majority of the populace lives in the rural areas, where the use of herbal medicines is common. The use of herbal medicines in the urban areas is on the increase, arising from the global inflationary trend, which hampers the sustainable supply of orthodox medicines and reduces the purchasing power of the populace. The Nigerian Government has recognized the need and shown political will by approving and adopting guidelines for the practice of traditional medicine. The regulatory authority, the National Agency for Food and Drug Administration and Control (NAFDAC), has also taken steps to protect the health of consumers by drafting the 'Guidelines for the Registration and Control of Herbal Medicinal Products and Related Substances in Nigeria'. Three broad classes are defined in the Guidelines, and preparations will be considered under four categories, each of which has its protocol. Extemporaneous preparations are only to be listed and not registered or advertised. Post-listing evaluation or monitoring is, however, mandatory. Herbal medicinal products manufactured on a large scale, whether imported or locally manufactured, must be registered and their advertisement messages and scripts approved by NAFDAC prior to their marketing. Homeopathic medicinal products must be registered and their advertisement messages approved prior to marketing. Post-registration evaluation or monitoring is also mandatory for both large-scale herbal medicinal products and homeopathic products.
KW - consumer protection
KW - health
KW - herbal drugs
KW - homeopathic drugs
KW - medicinal plants
KW - natural products
KW - registration
KW - regulations
KW - traditional medicine
KW - Nigeria
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - consumer advocacy
KW - drug plants
KW - folk medicine
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - rules
KW - Laws and Regulations (DD500)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033109007&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Developmental toxicants potentially acting via folate perturbation.
AU - Hansen, D. K.
A2 - Massaro, E. J.
A2 - Rogers, J. M.
T2 - Folate and human development
Y1 - 2002///
CY - Totowa; USA
PB - Humana Press
SN - 0896039366
AD - Hansen, D. K.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.
N1 - Accession Number: 20033104094. Publication Type: Book chapter. Language: English. Number of References: 154 ref. Registry Number: 59-30-3, 67-56-1, 10024-97-2, 57-41-0, 738-70-5, 99-66-1. Subject Subsets: Human Nutrition
N2 - This chapter identifies compounds that may alter folate levels/metabolism such as, trimethoprim, sulfasalazine, fumonisin B1, and methanol. Developmental toxicants which may not act via folate perturbation (carbamazepine, smoking) and those which may act via folate perturbation (phenytoin, valproic acid, alcohol, nitrous oxide) are discussed. It is concluded that alterations in folate uptake or metabolism may occur by a number of mechanisms, including genetic polymorphisms and environmental exposures.
KW - alcoholic beverages
KW - environmental factors
KW - folic acid
KW - fumonisins
KW - genetic polymorphism
KW - interactions
KW - metabolism
KW - methanol
KW - nitrous oxide
KW - phenytoin
KW - tobacco smoking
KW - trimethoprim
KW - valproic acid
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - carbamazepine
KW - diphenylhydantoin
KW - folacin
KW - folate
KW - fumonisin B1
KW - methyl alcohol
KW - sulfasalazine
KW - wood alcohol
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033104094&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Folate deficiency and the molecular determinants of chromosome instability - possible link to meiotic nondisjunction and down syndrome.
AU - James, S. J.
AU - Hobbs, C. A.
A2 - Massaro, E. J.
A2 - Rogers, J. M.
T2 - Folate and human development
Y1 - 2002///
CY - Totowa; USA
PB - Humana Press
SN - 0896039366
AD - James, S. J.: Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20033104102. Publication Type: Book chapter. Language: English. Number of References: 129 ref. Registry Number: 9007-49-2, 59-30-3. Subject Subsets: Human Nutrition
N2 - This chapter explores the relationship between folate deficiency and the molecular determinants of chromosome instability. Topics covered include: biochemistry and molecular genetics of folate and DNA metabolism; DNA methylation, chromatin configuration, and chromosome segregation; meiotic nondisjunction and Down's syndrome; and gene-nutrient interactions in the maternal risk of Down's syndrome - link to abnormal folate metabolism.
KW - biochemistry
KW - chromatin
KW - chromosomes
KW - DNA
KW - Down's syndrome
KW - folic acid
KW - folic acid deficiency
KW - genotype nutrition interaction
KW - meiosis
KW - metabolism
KW - methylation
KW - molecular genetics
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - folacin
KW - folate
KW - mongolism
KW - reduction division
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033104102&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Lead.
AU - Madden, E. F.
AU - Sexton, M. J.
AU - Smith, D. R.
AU - Fowler, B. A.
A2 - Sarkar, B.
T2 - Heavy metals in the environment
Y1 - 2002///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706307
AD - Madden, E. F.: Center for Devices and Radiological Health, U.S. Food & Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20023060723. Publication Type: Book chapter. Language: English. Number of References: 255 ref. Registry Number: 7439-92-1.
N2 - This chapter identifies the sources of lead released in the environment, the human body burdens, and the population at risk of lead exposure. The analytical methods used for the assessment of lead exposure and metabolism, and chelation treatment for lead poisoning are described. The toxicological effects of lead as evidenced by animal, in vitro and human epidemiological studies, and the molecular factors that determine these effects are reviewed. The role of lead in the induction of neurobehavioural, neurological, developmental, reproductive, renal and cardiovascular disorders and neoplasms, as well as in haemoglobin biosynthesis are discussed.
KW - analytical methods
KW - animal models
KW - cardiovascular diseases
KW - chelation
KW - epidemiology
KW - growth disorders
KW - haemoglobin
KW - human diseases
KW - in vitro
KW - kidney diseases
KW - lead
KW - lead poisoning
KW - mental disorders
KW - metabolism
KW - neoplasms
KW - nervous system diseases
KW - reproductive disorders
KW - risk groups
KW - therapy
KW - toxic substances
KW - toxicity
KW - toxicology
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - cancers
KW - hemoglobin
KW - kidney disorders
KW - mental illness
KW - nephropathy
KW - neuropathy
KW - poisons
KW - psychiatric disorders
KW - renal diseases
KW - therapeutics
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023060723&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiology of Lyme borreliosis.
AU - Dennis, D. T.
AU - Hayes, E. B.
A2 - Gray, J.
A2 - Kahl, O.
A2 - Lane, R. S.
A2 - Stanek, G.
T2 - Lyme borreliosis: biology, epidemiology and control
Y1 - 2002///
CY - Wallingford; UK
PB - CABI Publishing
SN - 0851996329
AD - Dennis, D. T.: Division of Vector-borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20023157177. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
KW - acaricides
KW - chemical control
KW - chemoprophylaxis
KW - cost benefit analysis
KW - disease prevention
KW - disease transmission
KW - epidemiology
KW - human diseases
KW - immunization
KW - insect control
KW - insect repellents
KW - Lyme disease
KW - pregnancy
KW - reservoir hosts
KW - reviews
KW - risk factors
KW - vaccination
KW - vaccines
KW - vector control
KW - women
KW - Europe
KW - North America
KW - Borrelia burgdorferi
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - animal reservoirs
KW - bacterium
KW - gestation
KW - immune sensitization
KW - lyme borreliosis
KW - Health Economics (EE118) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157177&site=ehost-live&scope=site
UR - http://www.cabi.org/CABeBooks/default.aspx?site=107&page=45&LoadModule=PDFHier&BookID=132
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vaccination against Lyme borreliosis.
AU - Hayes, E. B.
AU - Schriefer, M. E.
A2 - Gray, J.
A2 - Kahl, O.
A2 - Lane, R. S.
A2 - Stanek, G.
T2 - Lyme borreliosis: biology, epidemiology and control
Y1 - 2002///
CY - Wallingford; UK
PB - CABI Publishing
SN - 0851996329
AD - Hayes, E. B.: Division of Vector-borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20023157178. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
KW - children
KW - DNA vaccines
KW - epidemiology
KW - human diseases
KW - immunization
KW - Lyme disease
KW - recombinant vaccines
KW - safety
KW - tickborne diseases
KW - vaccination
KW - vaccine development
KW - vaccines
KW - Borrelia burgdorferi
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immune sensitization
KW - lyme borreliosis
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157178&site=ehost-live&scope=site
UR - http://www.cabi.org/CABeBooks/default.aspx?site=107&page=45&LoadModule=PDFHier&BookID=132
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Ecology of Borrelia burgdorferi sensu lato in North America.
AU - Piesman, J.
A2 - Gray, J.
A2 - Kahl, O.
A2 - Lane, R. S.
A2 - Stanek, G.
T2 - Lyme borreliosis: biology, epidemiology and control
Y1 - 2002///
CY - Wallingford; UK
PB - CABI Publishing
SN - 0851996329
AD - Piesman, J.: Division of Vector-borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20023157176. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
KW - animal ecology
KW - disease vectors
KW - diversity
KW - geographical distribution
KW - habitats
KW - human diseases
KW - Lyme disease
KW - microbial ecology
KW - nymphs
KW - reservoir hosts
KW - reviews
KW - taxonomy
KW - tickborne diseases
KW - North America
KW - Borrelia burgdorferi
KW - man
KW - Metastigmata
KW - vertebrates
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - America
KW - animal reservoirs
KW - bacterium
KW - lyme borreliosis
KW - systematics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Animal Ecology (ZZ332)
KW - Microbial Ecology (ZZ333) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023157176&site=ehost-live&scope=site
UR - http://www.cabi.org/CABeBooks/default.aspx?site=107&page=45&LoadModule=PDFHier&BookID=132
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Francisella.
AU - Elkins, K. L.
AU - Nano, F. E.
A2 - Sussman, M.
T2 - Molecular medical microbiology: Volumes 1-3
Y1 - 2002///
CY - London; UK
PB - Academic Press
SN - 0126775303
AD - Elkins, K. L.: Center for Biologics Evaluation and Research, FDA, Building 29 Room 428, 1401 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20023051309. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This chapter discusses the classification and identification, the surface, secreted and virulence-associated components, genetics, pathogenesis, immunity, presentation and diagnosis, antibacterial therapy, epidemiology and vaccination of Francisella infection.
KW - antibacterial agents
KW - classification
KW - diagnosis
KW - drug therapy
KW - epidemiology
KW - genetics
KW - human diseases
KW - identification
KW - immunity
KW - immunization
KW - pathogenesis
KW - tularaemia
KW - vaccination
KW - virulence
KW - Francisella
KW - Francisella tularensis
KW - man
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Francisella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - chemotherapy
KW - immune sensitization
KW - tularemia
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Morphology of Microorganisms (ZZ392) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023051309&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Aflatoxin, hepatitis and worldwide liver cancer risks.
AU - Henry, S. H.
AU - Bosch, F. X.
AU - Bowers, J. C.
A2 - DeVries, J. W.
A2 - Trucksess, M. W.
A2 - Jackson, L. S.
T2 - Mycotoxins and food safety: Proceedings of an American Chemical Society symposium held in Washington, DC, USA, on 21-23 August 2000
T3 - Advances in Experimental Medicine and Biology Volume 504
Y1 - 2002///
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0306467801
AD - Henry, S. H.: U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20033204440. Publication Type: Book chapter; Conference paper. Note: Advances in Experimental Medicine and Biology Volume 504 Language: English. Number of References: 16 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Aflatoxins are among the most potent mutagenic and carcinogenic substances known. Differential potency of aflatoxin among species can be partially attributed to differences in metabolism; however, current information on competing aspects of metabolic activation and detoxification of aflatoxin in various species does not identify an adequate animal model for humans. Risk of liver cancer is influenced by a number of factors, most notably carriage of hepatitis B virus as determined by the presence in serum of the hepatitis B surface antigen (HBsAg+ or HBsAg-). About 50 to 100% of liver cancer cases are estimated to be associated with persistent infection of hepatitis B (or C) virus. The potency of aflatoxin in HBsAg+ individuals is substantially higher (about a factor of 30) than the potency in HBsAg- individuals. Thus, reduction of the intake of aflatoxins in populations with a high prevalence of HBsAg+ individuals will have greater impact on reducing liver cancer rates than reductions in populations with a low prevalence of HbsAg+ individuals. The present analysis suggests that vaccination against hepatitis B (or protection against hepatitis C), which reduces prevalence of carriers, would reduce the potency of the aflatoxins in vaccinated populations and reduce liver cancer risk.
KW - aflatoxins
KW - hepatitis B
KW - hepatitis C
KW - human diseases
KW - liver
KW - liver cancer
KW - mycotoxins
KW - neoplasms
KW - reviews
KW - hepatitis B virus
KW - hepatitis C virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - fungal toxins
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033204440&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Electrospray mass spectrometry for fumonisin detection and method validation.
AU - Musser, S. M.
AU - Eppley, R. M.
AU - Trucksess, M. W.
A2 - DeVries, J. W.
A2 - Trucksess, M. W.
A2 - Jackson, L. S.
T2 - Mycotoxins and food safety: Proceedings of an American Chemical Society symposium held in Washington, DC, USA, on 21-23 August 2000
T3 - Advances in Experimental Medicine and Biology Volume 504
Y1 - 2002///
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0306467801
AD - Musser, S. M.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20033204447. Publication Type: Book chapter; Conference paper. Note: Advances in Experimental Medicine and Biology Volume 504 Language: English. Number of References: 37 ref. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - Fumonisins are a structurally related group of mycotoxins, characterized by a 19-20 carbon aminopolyhydroxy-alkyl chain which is diesterified with propane-1,2,3-tricarboxylic acid (tricarballylic acid). These mycotoxins are commonly found in corn and corn-based food products and have been linked to a variety of animal toxicities. The widespread prevalence of fumonisins and the toxicity associated with ingestion has resulted in a number of analytical methods for determining the amount of fumonisins present in foods. Among the most common of these methods are liquid chromatographic (LC) separation with fluorescence detection, enzyme-linked immunosorbent assay (ELISA) and LC/mass spectrometry. LC and ELISA give quantitative results while LC/MS provide quantitative analysis as well as confirmation of identity of the fumonisins.
KW - analytical methods
KW - ELISA
KW - food contamination
KW - fumonisins
KW - liquid chromatography
KW - mass spectrometry
KW - analytical techniques
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033204447&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - U.S. perspective on mycotoxin regulatory issues.
AU - Park, D. L.
AU - Troxell, T. C.
A2 - DeVries, J. W.
A2 - Trucksess, M. W.
A2 - Jackson, L. S.
T2 - Mycotoxins and food safety: Proceedings of an American Chemical Society symposium held in Washington, DC, USA, on 21-23 August 2000
T3 - Advances in Experimental Medicine and Biology Volume 504
Y1 - 2002///
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0306467801
AD - Park, D. L.: Office of Plant and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20033204445. Publication Type: Book chapter; Conference paper. Note: Advances in Experimental Medicine and Biology Volume 504 Language: English. Number of References: 20 ref. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - Control programmes set up by the Food and Drug Administration (FDA) for aflatoxin, an unavoidable natural contaminant produced by specific moulds that invade a number of feedstuffs and basic foods, provide an example of forces that affect risk assessment and management strategies by a regulatory agency. More recently, on an international scale, efforts to establish international food standards for fumonisin, deoxynivalenol, ochratoxin A, zearalenone, and patulin, as well as for aflatoxin, demonstrate the complexity of developing regulations and/or standards designed to protect consumer health and ensure fair trade practices on a global scale. Current FDA regulations for aflatoxins address public health concerns for potential contamination in basic foods, residues in milk, and animal feeds for numerous commodities and applications. Regulatory limits, sampling and analytical procedures, decontamination and/or diversion to less risk uses for contaminated product are components of mycotoxin control programmes. Current efforts by FDA to establish regulatory controls for deoxynivalenol, fumonisin, and patulin add further insight on the role that safety and risk assessment procedures play in the development of action levels and advisories for mycotoxins.
KW - aflatoxins
KW - decontamination
KW - food contamination
KW - food safety
KW - fumonisins
KW - mycotoxins
KW - regulations
KW - food contaminants
KW - fungal toxins
KW - rules
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033204445&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effect of processing on aflatoxin.
AU - Park, D. L.
A2 - DeVries, J. W.
A2 - Trucksess, M. W.
A2 - Jackson, L. S.
T2 - Mycotoxins and food safety: Proceedings of an American Chemical Society symposium held in Washington, DC, USA, on 21-23 August 2000
T3 - Advances in Experimental Medicine and Biology Volume 504
Y1 - 2002///
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0306467801
AD - Park, D. L.: Division of Natural Products, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20033204434. Publication Type: Book chapter; Conference paper. Note: Advances in Experimental Medicine and Biology Volume 504 Language: English. Number of References: 36 ref. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - Naturally occurring toxicant contamination of foods with mycotoxins is unavoidable and unpredictable and poses a unique challenge to food safety. Aflatoxins are toxic mould metabolites produced by toxigenic strains of Aspergillus species. Primary commodities susceptible to aflatoxin contamination include corn, peanuts and cottonseed and animal-derived foods such as milk when the animal is fed aflatoxin-contaminated feed. Risks associated with aflatoxin-contaminated foods can be reduced through the use of specific processing and decontamination procedures. Factors, which influence the effectiveness of a specific process or procedure, include the chemical stability of the mycotoxin(s), nature of the process, type and interaction with the food/feed matrix and interaction with multiple mycotoxins if present. Practical decontamination procedures must: (1) inactivate, destroy, or remove the toxin, (2) not produce or leave toxic residues in the food/feed, (3) retain the nutritive value of the food/feed, (4) not alter the acceptability or the technological properties of the product, and, if possible, (5) destroy fungal spores. For aflatoxins, multiple processing and/or decontamination schemes have been successful in reducing aflatoxin concentrations to acceptable levels. Physical cleaning and separation procedures, where the mould-damaged kernel/seed/nut is removed from the intact commodity, can result in 40-80% reduction in aflatoxins levels. Processes such as dry and wet milling result in the distribution of aflatoxin residues into less utilized fractions of the commodity. The ammoniation of aflatoxin-contaminated commodities has altered the concentrations as well as toxic and carcinogenic effects of aflatoxin by greater than 99%. Nonbiological materials such as selected anticaking agents covalently bind aflatoxins from aqueous suspensions, diminish aflatoxin uptake by animals, prevent acute aflatoxicosis, and decrease aflatoxin residues in milk. Ultimately, the best processing or decontamination process is one that is approved by regulatory agencies, cost-effective, and reduces the mycotoxin concentration to acceptable levels.
KW - aflatoxins
KW - cleaning
KW - decontamination
KW - detoxification
KW - food contamination
KW - food safety
KW - milling
KW - mycotoxins
KW - food contaminants
KW - fungal toxins
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033204434&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - HPLC detection of patulin in apple juice with GC/MS confirmation of patulin identity.
AU - Roach, J. A. G.
AU - Brause, A. R.
AU - Eisele, T. A.
AU - Rupp, H. S.
A2 - DeVries, J. W.
A2 - Trucksess, M. W.
A2 - Jackson, L. S.
T2 - Mycotoxins and food safety: Proceedings of an American Chemical Society symposium held in Washington, DC, USA, on 21-23 August 2000
T3 - Advances in Experimental Medicine and Biology Volume 504
Y1 - 2002///
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0306467801
AD - Roach, J. A. G.: U.S. Food and Drug Administration, CFSAN, 200 C St., SW, Washington, DC 20204, USA.
N1 - Accession Number: 20033204431. Publication Type: Book chapter; Conference paper. Note: Advances in Experimental Medicine and Biology Volume 504 Language: English. Number of References: 10 ref. Registry Number: 149-29-1. Subject Subsets: Medical & Veterinary Mycology
N2 - The official patulin LC procedure was further examined (AOAC 995.10). Juice or juice concentrate was extracted with ethyl acetate and cleaned up with sodium carbonate. Patulin in the dried extract was determined by reversed-phase LC with UV detection (280 nm) in 1% THF aqueous solution after evaporation of the ethyl acetate. An end-capped C18 column was required to separate patulin from hydroxymethylfurfural. Patulin was detected in approximately half of the >1000 extracts examined. Only ca 10% of the extracts contained patulin at levels greater than 50 µg/L (50 ppb). Some presumptive findings were confirmed by capillary gas chromatography/mass spectrometry as the trimethyl silyl derivative using electron ionization or as underivatized patulin using negative ion chemical ionization. Trifluoropropylmethyl polysiloxane capillary columns provided superior gas chromatography of underivatized patulin compared to phenyl/methyl polysiloxane and methyl polysiloxane columns.
KW - apple juice
KW - food contamination
KW - food safety
KW - gas chromatography
KW - HPLC
KW - mass spectrometry
KW - patulin
KW - food contaminants
KW - high performance liquid chromatography
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033204431&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The United States approach to regulation development.
AU - McChesney, D. G.
A2 - Garnsworthy, P. C.
A2 - Wiseman, J.
T2 - Recent advances in animal nutrition 2002
Y1 - 2002///
CY - Nottingham; UK
PB - Nottingham University Press
SN - 1897676093
AD - McChesney, D. G.: Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville MD 20853, USA.
N1 - Accession Number: 20023193198. Publication Type: Book chapter. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - This chapter details the approach used to develop regulations that are binding on industries regulated by the United States Food and Drug Administration. In general, this approach is used by all Departments within the United States government. The chapter discusses the legal authority under which the United States Food and Drug Administration regulates food and animal feed, provides an overview of the regulation development process, uses the BSE regulation to illustrate the regulation development process, and concludes with a discussion of enforcement actions that can result from non-compliance with a regulation.
KW - animal feeding
KW - animal products
KW - feeds
KW - food safety
KW - public health
KW - regulations
KW - reviews
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Science and Food Products (Human) (QQ000)
KW - Forage and Feed Products (Non-human) (RR000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20023193198&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An overview of Salmonella typing: public health perspectives.
AU - Yan, S. S.
AU - Pendrak, M. L.
AU - Abela-Ridder, B.
AU - Punderson, J. W.
AU - Fedorko, D. P.
AU - Foley, S. L.
JO - Clinical and Applied Immunology Reviews
JF - Clinical and Applied Immunology Reviews
Y1 - 2003///
VL - 4
IS - 3
SP - 189
EP - 204
CY - New York; USA
PB - Elsevier Science Inc.
SN - 1529-1049
AD - Yan, S. S.: Division of Human Food Safety, FDA Center for Veterinary Medicine, Rockville, Maryland, USA.
N1 - Accession Number: 20043054317. Publication Type: Journal Article. Language: English. Number of References: 110 ref. Subject Subsets: Public Health
N2 - The genus Salmonella is a group of highly adaptive Gram-negative bacilli containing a number of closely related serotypes, many of which are potentially pathogenic for humans and/or animals. Salmonella infections are capable of producing serious infections that are often foodborne and present as gastroenteritis, however, a small percentage of these infections may become invasive and result in bacteremia and serious extraintestinal disease. The epidemiological characteristics of a Salmonella outbreak drive interest in the identification of the serotype and other identifiable characteristics including antimicrobial susceptibility and emergence of multidrug resistance patterns. A variety of methods have been developed to identify serotypes. Public health concerns and the potential for foodborne zoonotic transmission have made Salmonella the subject of numerous international, national, and local surveillance programs.
KW - multiple drug resistance
KW - pathogenesis
KW - public health
KW - reviews
KW - salmonellosis
KW - serotypes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Salmonella infections
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbiology (General) (ZZ390)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043054317&site=ehost-live&scope=site
UR - email: sfoley@mail.uca.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phenotype of peroxisome proliferator-activated receptor-α (PPARα) deficient mice on mixed background fed high fat diet.
AU - Kim BangHyun
AU - Won YoungSuk
AU - Kim EunYoung
AU - Yoon MiJung
AU - Nam KiTaek
AU - Oh GooTaeg
AU - Kim DaeYong
JO - Journal of Veterinary Science
JF - Journal of Veterinary Science
Y1 - 2003///
VL - 4
IS - 3
SP - 239
EP - 244
CY - Daejon; Korea Republic
PB - Korean Society of Veterinary Science
SN - 1229-845X
AD - Kim BangHyun: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20043005061. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Agricultural Biotechnology; Human Nutrition; Animal Breeding
N2 - Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-α (PPARα) on obesity. Previous reports demonstrated that PPARα is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARα-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARα-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARα-/- mice on mixed genetic background (C57BL/6N × 129/Sv) fed a high fat diet for 16 weeks. PPARα-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARα target genes encoding enzymes for fatty acid β-oxidation.
KW - adipose tissue
KW - animal models
KW - biochemical receptors
KW - diets
KW - fatty acids
KW - genes
KW - growth rate
KW - human diseases
KW - lipid metabolism
KW - liver
KW - obesity
KW - peroxisomes
KW - phenotypes
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fat metabolism
KW - fatness
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Animal Nutrition (Physiology) (LL510)
KW - Animal Models of Human Nutrition (VV140)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043005061&site=ehost-live&scope=site
UR - email: daeyong@snu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Type IV transporters of pathogenic bacteria.
AU - Burns, D. L.
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
Y1 - 2003///
VL - 6
IS - 1
SP - 29
EP - 34
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 1369-5274
AD - Burns, D. L.: United States Food and Drug Administration, HFM-434, Building 29, Room 130, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033089385. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology
N2 - Type IV transporters are produced by several bacterial pathogens such as Agrobacterium tumefaciens, Bordetella pertussis, Brucella spp., Bartonella henselae, Helicobacter pylori and Legionella pneumophila. These transporters are critical for the pathogenic process in that they export important virulence factors across the membranes of the bacteria. Although the virulence factors that are exported by these transporters can be either nucleic acid or protein, the general mechanism of transport appears to be similar for members of this family. A review of recent findings has shed light on the architecture of type IV transporters and the roles that these transporters play in pathogenesis.
KW - bacterial proteins
KW - biochemical transporters
KW - nucleic acids
KW - pathogenesis
KW - pathogenicity
KW - pathogens
KW - plant pathogenic bacteria
KW - plant pathogens
KW - reviews
KW - virulence
KW - Bartonella henselae
KW - Bordetella pertussis
KW - Brucella
KW - Helicobacter pylori
KW - Legionella pneumophila
KW - Rhizobium
KW - Rhizobium radiobacter
KW - Bartonella
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Brucellaceae
KW - Helicobacter
KW - Helicobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Legionella
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Rhizobium
KW - Rhizobiaceae
KW - Agrobacterium
KW - Agrobacterium tumefaciens
KW - bacterium
KW - phytopathogenic bacteria
KW - phytopathogens
KW - plant-pathogenic bacteria
KW - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033089385&site=ehost-live&scope=site
UR - email: burns@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment and significance of 24-h energy intake patterns among young and aged non-affluent Southern U.S. women.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - Freni, S. C.
AU - Cardoso, S. S.
AU - Buffington, C.
AU - Jairaj, K.
AU - Turturro, A.
AU - Feuers, R. J.
JO - Journal of Nutrition, Health & Aging
JF - Journal of Nutrition, Health & Aging
Y1 - 2003///
VL - 7
IS - 2
SP - 78
EP - 83
CY - Paris; France
PB - Serdi Edition
SN - 1279-7707
AD - Lewis, S. M.: The Bionetics Corporation, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033184833. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition
N2 - Energy intake patterns that may impact health status among non-affluent southern USA women from small urban communities have not been evaluated extensively. Usual intake estimates are confounded by factors such as validity of intake methods and socioeconomic status. Typical 24-h energy intakes were reported by Caucasian (CA, n=149) and African-American (AA, n=110) women; at 43% of this subpopulation, AA women were appropriately and proportionately represented. Daily energy intake was examined for these non-pregnant females (aged 24-93 years) to define typical energy, carbohydrate, protein and fat intake. The study groups were divided into age groups: 24-29, 30-39, 40-49, 50-59, 60-69, 70-79 and 80-93 years. Statistical comparisons of nutrient variables by age were made by least squares means between groups. Body mass index (BMI) calculations accounted for differences in height and relative body mass. Both races reported similar energy intakes and significant (P<0.05) decreases with age were noted. Energy intakes were 15-40% below recommended levels, similar to reported values; senior lunch programmes ameliorated declines among some women >60 years. More daily calories (52-62%) were provided by carbohydrates, followed by fat (26-35%) and protein (14-17%); these findings were in close agreement with health recommendations. Time-of-day intake patterns suggested that women >59 years consumed larger noon meals. BMI for AA women was greater (P<0.05) than that of CA women aged 30-59 years. At 24-29 years, AA women had the lowest BMI values; BMI decreased in CA women after 80 years. These factors may impact the health of non-affluent southern AA and CA women, particularly the elderly who may require guidance for diet planning and intake intervention programmes.
KW - age differences
KW - age groups
KW - body mass index
KW - calories
KW - carbohydrates
KW - dietary fat
KW - dietary protein
KW - elderly
KW - energy intake
KW - ethnic groups
KW - fat consumption
KW - food intake
KW - protein intake
KW - socioeconomic status
KW - whites
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - African-Americans
KW - aged
KW - elderly people
KW - older adults
KW - saccharides
KW - senior citizens
KW - source fat
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Women (UU500)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033184833&site=ehost-live&scope=site
UR - email: rfeuers@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of antioxidant nutrient intake of a population of Southern U.S. African-American and caucasian women of various ages when compared to dietary reference intakes.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - Freni, S. C.
AU - Thorn, B.
AU - Cardoso, S.
AU - Buffington, C.
AU - Jairaj, K.
AU - Feuers, R. J.
JO - Journal of Nutrition, Health & Aging
JF - Journal of Nutrition, Health & Aging
Y1 - 2003///
VL - 7
IS - 2
SP - 121
EP - 128
CY - Paris; France
PB - Serdi Edition
SN - 1279-7707
AD - Lewis, S. M.: The Bionetics Corporation, 3900 NCTR Road, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033184830. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 59-02-9, 50-81-7, 7235-40-7, 7440-50-8, 7439-89-6, 7439-96-5, 7439-98-7, 68-26-8, 83-88-5, 7782-49-2, 1406-18-4, 7440-66-6. Subject Subsets: Human Nutrition
N2 - This study examined the 24-h intake of vitamins (A, E, C, β-carotene, α-tocopherol and riboflavin) and minerals (zinc, selenium, copper, manganese, iron and molybdenum) of 259 Caucasian (CA) and African-American (AA) women from small urban communities in southern USA. Women were non-pregnant females, 19-93 years of age. Statistical comparisons of nutrient intake were made by least squares means within age groups. Intakes were compared to various dietary reference intakes including Recommended Daily Allowance (RDA) and Estimated Average Requirement (EAR) values as established by the U.S. National Research Council. Numerous dietary deficiencies in important antioxidant nutrients associated with metabolic antioxidant systems were identified. Few race-related differences were detected. Intake of vitamin A was generally within recommended levels, whereas vitamin E intake was below the EAR. The vitamin precursors, β-carotene and α-tocopherol, were significantly (P<0.05) below customary intakes at all ages. More than 60% of this population reported dietary copper, zinc and selenium intakes below recommended levels. A lack of race differences for most nutrient intakes suggests similar socioeconomic or endogenous regional factors. All women in this population reported dietary intakes of antioxidant vitamins and minerals below recommended values, conditions that could contribute to subsequent health risks unless nutrient-dense food choices and antioxidant supplementation are considered in their overall nutritional support.
KW - age
KW - alpha-tocopherol
KW - antioxidants
KW - ascorbic acid
KW - beta-carotene
KW - copper
KW - ethnic groups
KW - ethnicity
KW - iron
KW - manganese
KW - minerals
KW - molybdenum
KW - nutrient deficiencies
KW - nutrient intake
KW - recommended dietary allowances
KW - retinol
KW - riboflavin
KW - selenium
KW - urban areas
KW - vitamin E
KW - vitamins
KW - whites
KW - women
KW - zinc
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - African-Americans
KW - axerophthol
KW - ethnic differences
KW - Mn
KW - Mo
KW - RDA
KW - recommended dietary intakes
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - vitamin B2
KW - vitamin C
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Women (UU500)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033184830&site=ehost-live&scope=site
UR - email: rfeuers@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Campylobacter as a foodborne pathogen and its impact on human health.
AU - Nayak, R.
AU - Nawaz, M.
AU - Khan, A.
AU - Khan, S.
JO - Recent Research Developments in Microbiology
JF - Recent Research Developments in Microbiology
Y1 - 2003///
VL - 7
IS - 2
SP - 585
EP - 606
CY - Trivandrum; India
PB - Research Signpost
AD - Nayak, R.: United States Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043154887. Publication Type: Journal Article. Language: English. Number of References: 186 ref. Subject Subsets: Public Health; Poultry; Human Nutrition
N2 - The epidemiology (world-wide), pathogenesis, clinical aspects, treatment and control of infections caused by the foodborne pathogen, Campylobacter, are discussed. A brief discussion on the risk assessment of Campylobacter contamination of food, specifically broiler chickens, is also presented.
KW - chicken meat
KW - clinical aspects
KW - disease prevalence
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - pathogenesis
KW - poultry
KW - world
KW - Campylobacter
KW - fowls
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - bacterium
KW - chickens
KW - clinical picture
KW - domesticated birds
KW - food contaminants
KW - worldwide
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043154887&site=ehost-live&scope=site
UR - email: Mnawaz@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Understanding biotechnology in agriculture.
AU - Crawford, L. M.
JO - Agricultural Biotechnology
JF - Agricultural Biotechnology
Y1 - 2003///
VL - 8
IS - 3
SP - 1
EP - 5
CY - Washington; USA
PB - United States Department of Agriculture (USDA)
AD - Crawford, L. M.: U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857-0001, USA.
N1 - Accession Number: 20043177232. Publication Type: Journal Article. Language: English. Subject Subsets: Agricultural Biotechnology; World Agriculture, Economics & Rural Sociology; Plant Breeding
N2 - This paper covers some of the basic science behind biotechnology including cross-breeding, hybridization and bioengineering; the US regulatory structure for ensuring food safety and the US policy in the issue of labelling transgenic crops.
KW - biotechnology
KW - food safety
KW - genetically engineered organisms
KW - hybridization
KW - labelling
KW - plant breeding
KW - regulations
KW - transgenic plants
KW - USA
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - labeling
KW - labels
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Plant Breeding and Genetics (FF020)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043177232&site=ehost-live&scope=site
UR - http://usinfo.state.gov/journals/ites/0903/ijee/crawford.htm
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health risk assessment of lead in the Republic of Korea.
AU - Lee HyoMin
AU - Yoon EunKyung
AU - Hwang MyungSil
AU - Lee GunYoung
AU - Hong MooKi
AU - Yang JiSun
AU - Yang KiHwa
AU - Shin HyoSun
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
Y1 - 2003///
VL - 9
IS - 7
SP - 1801
EP - 1812
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 1080-7039
AD - Lee HyoMin: Department of Risk Assessment, Korea Food and Drug Administration, Eunpyung-ku, Seoul, Korea Republic.
N1 - Accession Number: 20083143282. Publication Type: Journal Article. Language: English. Registry Number: 7439-92-1. Subject Subsets: Tropical Diseases
N2 - The purpose of this study was to estimate the daily exposure to lead due to food ingestion, air inhalation, and soil ingestion in the Republic of Korea's general population, and to evaluate the level of risk associated with the current lead exposure level using the proportional daily dose (3-4 µg/kg body weight/day) corresponding to the Provisional Tolerable Weekly Intake (PTWI) suggested by the Joint FAO/WHO Expert Committee on Food Additives as the toxicological tolerance level. The estimation of the daily exposure to lead via three pathways including food, soil ingestion and air inhalation was conducted as a chronic exposure assessment. For the lead exposure assessment through dietary intake, 1,389 lead residue data for 45 commodities investigated by the Korea Food and Drug Administration during the period 1995-2000 were utilized (KFDA 1996, 1997, 1998). Six hundred seventy-two air monitoring data from 7 major cities during the period 1993-2000 and 4,500 soil residue data at 1,500 sites during the period 1999-2001 were considered for the lead exposure assessment involving air inhalation and soil ingestion, respectively. The total daily exposure to lead was estimated by combining dietary intake, inhaled amount and soil intake corresponding to the typical activity of the general population, which was treated as a group of adults with a body weight of 60 kg. For risk characterization, the daily exposure to lead was compared with the toxicological tolerance level. The level of risk due to lead exposure was calculated using the hazard ratio (HR). The dietary intake of lead was 9.71×10-4 mg/kg/day and the total daily exposure level, including air inhalation and soil ingestion, was 9.97×10-4 mg/kg/day. The exposure contributions of foods, air and soil induced from the percentage of each media to the total daily exposure were 97.4%, 2.1% and 0.5%, respectively. Of the different commodity groups, the highest contribution to the total exposure came from grain, which represented 47.7% of the total. Additional exposure to lead occurs in certain population groups due to the use of tobacco, alcoholic beverages, and the intake of other foods, all factors not considered in this study. Through the comparison of the daily exposure to lead with the tolerance level based on the PTWI, the hazard ratio was estimated as being 0.25-0.33. This value implies that no increase in blood lead level is to be expected in the general population at the current lead exposure levels.
KW - additives
KW - alcoholic beverages
KW - body weight
KW - characterization
KW - exposure
KW - foods
KW - health hazards
KW - lead
KW - lead poisoning
KW - monitoring
KW - risk assessment
KW - soil
KW - tobacco
KW - tolerance
KW - toxicology
KW - urban areas
KW - Korea Republic
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - adjuncts
KW - Korea
KW - South Korea
KW - surveillance systems
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Field Crops (FF005) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083143282&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a714044798~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in Western Kenya.
AU - Chaisavaneeyakorn, S.
AU - Othoro, C.
AU - Shi, Y. P.
AU - Otieno, J.
AU - Chaiyaroj, S. C.
AU - Lal, A. A.
AU - Udhayakumar, V.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2003///
VL - 10
IS - 3
SP - 362
EP - 366
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Chaisavaneeyakorn, S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033101556. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - In this study, we investigated whether levels of interleukin-12 (IL-12) and IL-18 in plasma are associated with severe malarial anemia outcomes in an area of holoendemicity in western Kenya. We compared plasma IL-12 and IL-18 levels in six groups of children grouped into the categories aparasitemic, asymptomatic, mild malaria, high-density uncomplicated malaria (UC), moderate malarial anemia (MMA), or severe malarial anemia (SMA). IL-12 levels were significantly reduced in children with SMA (P<0.05) but not in other groups compared to children in the aparasitemic control group. IL-18, a cytokine known to be critical for the induction of gamma interferon along with IL-12, was produced more frequently (70%) in children with UC (P=0.06) than in children in the aparasitemic control group (32%). However, in the SMA group the IL-18 response rate declined to 30%, which was similar to that in the aparasitemic control group, which showed a 32% response rate. This finding suggests that the IL-18 response may be impaired in children with SMA. In summary, the results from this study support the hypothesis that impairment of IL-12 and/or IL-18 response may contribute to the development of severe malarial anemia in areas of holoendemicity for malaria.
KW - anaemia
KW - children
KW - human diseases
KW - immune response
KW - interleukin 12
KW - interleukin 18
KW - interleukins
KW - malaria
KW - Kenya
KW - man
KW - Plasmodium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - anemia
KW - immunity reactions
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033101556&site=ehost-live&scope=site
UR - email: vxu0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of porcine endogenous retrovirus in cultures of freshly isolated porcine bone marrow cells.
AU - McIntyre, M. C.
AU - Kannan, B.
AU - Solano-Aguilar, G. I.
AU - Wilson, C. A.
AU - Bloom, E. T.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2003///
VL - 10
IS - 4
SP - 337
EP - 342
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0908-665X
AD - McIntyre, M. C.: Laboratory of Immunology and Virology (HFM-518), Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033172398. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9068-38-6. Subject Subsets: Veterinary Science; Veterinary Science; Agricultural Biotechnology; Pig Science
N2 - Pigs are under consideration as possible sources of organs for xenotransplantation in humans. The induction of hematopoietic microchimerism through xenotransplantation of source animal hematopoietic cells has been suggested as a means to induce tolerance in potential recipients. Because all porcine cells contain genetic information for porcine endogenous retrovirus (PERV), coculture techniques, reverse transcriptase (RT) and reverse transcriptase-polymerase chain reaction assays were used to determine whether infectious PERV is released from fresh porcine bone marrow cells cultured in the presence or absence of porcine cytokines. Human embryonic kidney cell line, HEK-293 cells cocultured with porcine bone marrow cells were positive for PERV RNA but never became positive for viral RT activity, suggesting the PERV infection was not productive. In contrast, high levels of RT activity was detected in porcine ST-IOWA Cells after coculture, demonstrating that these cells became productively infected. PERV was released from cultured porcine bone marrow cells without stimulation, and combinations of the porcine hematopoietic cytokines, interleukin-3, granulocyte macrophage-colony stimulating factor and stem cell factor had no additional effect on the infectivity or in vitro tropism of released PERV virions.
KW - bone marrow
KW - cell culture
KW - cytokines
KW - enzyme activity
KW - reverse transcriptase
KW - transplantation
KW - xenotransplantation
KW - pigs
KW - Retroviridae
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Retroviridae
KW - hogs
KW - porcine endogenous retrovirus
KW - swine
KW - Animal Tissue and Cell Culture (LL700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Cell, Tissue and Embryo Manipulation (WW300) (New June 2002)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033172398&site=ehost-live&scope=site
UR - email: bloom@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Levels of macrophage inflammatory protein 1α (MIP-1α) and MIP-1β in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infection.
AU - Chaisavaneeyakorn, S.
AU - Moore, J. M.
AU - Mirel, L.
AU - Othoro, C.
AU - Otieno, J.
AU - Chaiyaroj, S. C.
AU - Shi, Y. P.
AU - Nahlen, B. L.
AU - Lal, A. A.
AU - Udhayakumar, V.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2003///
VL - 10
IS - 4
SP - 631
EP - 636
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Chaisavaneeyakorn, S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033134275. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β play an important role in modulating immune responses. To understand their importance in immunity to placental malaria (PM) and in human immunodeficiency virus (HIV)-PM coinfection, we investigated levels of these chemokines in the placental intervillous blood plasma (IVB plasma) and cord blood plasma of HIV-negative PM-negative, HIV-negative PM-positive, HIV-positive PM-negative, and HIV-positive PM-positive women. Compared to HIV-negative PM-negative women, the MIP-1β concentration in IVB plasma was significantly elevated in HIV-negative PM-positive women and HIV-positive PM-positive women, but it was unaltered in HIV-positive PM-negative women. Also, PM-infected women, irrespective of their HIV status, had significantly higher levels of MIP-1β than HIV-positive PM-negative women. The MIP-1α level was not altered in association with either infection. The IVB plasma levels of MIP-1α and MIP-1β positively correlated with the cord blood plasma levels of these chemokines. As with IVB plasma, only cord plasma from PM-infected mothers had significantly elevated levels of MIP-1β compared to PM-negative mothers, irrespective of their HIV infection status. MIP-1β and MIP-1α levels in PM-positive women were positively associated with parasite density and malaria pigment levels. Regardless of HIV serostatus, the IVB MIP-1β level was significantly lower in women with PM-associated anemia. In summary, an elevated level of MIP-1β was associated with PM. HIV infection did not significantly alter these two chemokine levels in IVB plasma.
KW - blood plasma
KW - chemokines
KW - concurrent infections
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - macrophages
KW - malaria
KW - women
KW - Kenya
KW - man
KW - Plasmodium
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immunity reactions
KW - immunological reactions
KW - plasma (blood)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033134275&site=ehost-live&scope=site
UR - email: vxu0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acephate exposure and decontamination on tobacco harvesters' hands.
AU - Curwin, B. D.
AU - Hein, M. J.
AU - Sanderson, W. T.
AU - Nishioka, M.
AU - Buhler, W.
JO - Journal of Exposure Analysis and Environmental Epidemiology
JF - Journal of Exposure Analysis and Environmental Epidemiology
Y1 - 2003///
VL - 13
IS - 3
SP - 203
EP - 210
CY - New York; USA
PB - Nature America, Inc.
SN - 1053-4245
AD - Curwin, B. D.: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway MS R-14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20033105815. Publication Type: Journal Article. Language: English. Registry Number: 30560-19-1. Subject Subsets: Agricultural Entomology
N2 - Agricultural workers manually harvesting tobacco have the potential for high dermal exposure to pesticides, particularly on the hands. Often gloves are not worn as it hinders the harvesters' ability to harvest the tobacco leaves. To enable harvesters to remove pesticide residue on the hands and decrease absorbed doses, the EPA Worker Protection Standard requires growers to have hand-wash stations available in the field. The purpose of this study was to measure the concentration of acephate residue on the hands of tobacco harvesters, and the effectiveness of hand washing in reducing the acephate residue. Hand-wipes from the hands of 12 tobacco harvesters were collected at the end of the morning and at the end of the afternoon over 2 consecutive days. Each harvester had one hand-wiped prior to washing his hands, and the other hand-wiped after washing his hands with soap and water. In addition to the hand-wipe samples, leaf-wipe samples were collected from 15 tobacco plants to determine the amount of acephate residue on the plants. The average acephate level in leaf-wipe samples was 1.4 ng/cm2. The geometric mean prewash and postwash acephate levels on the hands were 10.5 and 0.4 ng/cm2, respectively. Both prewash (P-value=0.0009) and postwash hand (P-value=0.01) samples were positively correlated with leaf-wipe concentrations. Tobacco harvester position tended to influence hand exposure. Hand washing significantly reduced acephate levels on the hand, after adjusting for sampling period, hand sampled, job position, and leaf-wipe concentration (P-value≤0.0001) with levels reduced by 96%. A substantial amount of acephate was transferred to the hands, and while hand washing significantly reduced the amount of residue on the hands, not all residue was removed.
KW - acephate
KW - decontamination
KW - exposure
KW - insecticide residues
KW - insecticides
KW - leaves
KW - tobacco
KW - washing
KW - Nicotiana
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Field Crops (FF005) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033105815&site=ehost-live&scope=site
UR - http://www.nature.com/cgi-taf/DynaPage.taf?file=/jea/journal/v13/n3/abs/7500271a.html
UR - email: bcurwin@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Systematic screening of secondary diagnoses in medicare administrative data to identify candidate risk factors for the principal diagnosis.
AU - Baine, W. B.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2003///
VL - 13
IS - 6
SP - 443
EP - 449
CY - New York; USA
PB - Elsevier Science Inc.
SN - 1047-2797
AD - Baine, W. B.: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Department of Health and Human Services, Suite 300, 6010 Executive Boulevard, Rockville, MD 20852-3813, USA.
N1 - Accession Number: 20033143732. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - PURPOSE: Secondary diagnoses in Medicare hospital discharge claims may include risk factors for the principal diagnosis. However, risk ratios for the principal diagnosis as a function of secondary diagnoses cannot be calculated because no comparable data exist for beneficiaries who are not hospitalized. METHODS: Hospital discharge rates, as proxies for incidence rates, can be calculated by race and sex from Medicare claims and denominator files. If the prevalence of a risk factor is higher in one population group than another, that risk factor will be overrepresented among patients from the group at higher risk. RESULTS: This imbalance is reflected in what is termed the odds difference, OD=[(r+r′)/r][f2/(1-f2)-f1/(1-f1)], in which r is the background incidence rate, and r′ is the additional risk conferred by a factor that is present in fractions f1 and f2 in the two groups. Unlike the risk ratio, the odds difference can be calculated from claims data. Given f1 and f2, the odds difference is directly proportional to the risk ratio, RR=(r+r′)/r. CONCLUSIONS: Ranking common secondary diagnoses by the magnitude of their odds difference between groups with disparate discharge rates for a given principal diagnosis may disclose secondary diagnoses that merit evaluation as candidate direct or indirect risk factors.
KW - diagnosis
KW - health insurance
KW - human diseases
KW - Medicare
KW - risk assessment
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - screening tests
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143732&site=ehost-live&scope=site
UR - email: wbaine@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Deaths due to injuries among employed adults: the effects of socioeconomic class.
AU - Steenland, K.
AU - Halperin, W.
AU - Hu, S.
AU - Walker, J. T.
JO - Epidemiology
JF - Epidemiology
Y1 - 2003///
VL - 14
IS - 1
SP - 74
EP - 79
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1044-3983
AD - Steenland, K.: National Institute for Occupational Safety and Health (NIOSH), Atlanta, GA 30322, USA.
N1 - Accession Number: 20033161085. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background. Few studies have investigated socioeconomic status (SES) and external causes of death (ie, deaths attributable to injuries). These deaths are of particular interest because they are potentially preventable and they represent the second leading cause of years of life lost under age 75. Methods. We studied 261,723 deaths from external causes in 27 states from 1984 to 1997 among employed persons age 20-64. Numerator data came from occupation on the death certificate. Occupation-specific denominator data came from the U.S. Census. A Nam-Powers SES score was assigned to each occupation based on its relative income and education in the U.S. Census. Results. After adjusting for age, sex, year and race, SES was strongly associated with mortality from all external causes combined for men (rate ratios=2.9, 2.3, 1.5, and 1.0 by ascending SES quartile), and to a lesser extent for women (rate ratios=1.6, 1.0, 1.1, and 1.0). A similar pattern was seen for each of the specific external causes (motor vehicle deaths, suicide, homicide, injuries other than by motor vehicle, and medical complications). Conclusions. We estimate 41% of deaths from external causes are attributable to having a SES below the top quartile (both sexes combined).
KW - causes of death
KW - epidemiology
KW - homicide
KW - mortality
KW - occupational disorders
KW - occupational health
KW - personnel
KW - socioeconomic status
KW - socioeconomics
KW - suicide
KW - traffic accidents
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - employees
KW - murder
KW - socioeconomic aspects
KW - staff
KW - traumas
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033161085&site=ehost-live&scope=site
UR - email: nsteenl@sph.emory.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States).
AU - Steenland, K.
AU - Whelan, E.
AU - Deddens, J.
AU - Stayner, L.
AU - Ward, E.
JO - Cancer Causes & Control
JF - Cancer Causes & Control
Y1 - 2003///
VL - 14
IS - 6
SP - 531
EP - 539
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0957-5243
AD - Steenland, K.: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA.
N1 - Accession Number: 20033151990. Publication Type: Journal Article. Language: English. Registry Number: 75-21-8. Subject Subsets: Public Health
N2 - Background: Ethylene oxide (ETO) is a sterilant gas considered to be a human carcinogen, due primarily to excess hematopoietic cancer in exposed cohorts. ETO causes mammary tumors in mice, and has been associated with breast cancer incidence in one small epidemiologic study. Methods: We have studied breast cancer incidence in a cohort of 7576 women employed for at least one year and exposed for an average 10.7 years while working in commercial sterilization facilities. Breast cancer incidence (n=319) was ascertained via interview, death certificates, cancer registries, and medical records. Interviews were obtained for 68% of the cohort. Results: The standardized incidence ratio (SIR) for incident breast cancer in the whole cohort using external referent rates (SEER) was 0.87 (0.77-0.97). The SIR for those in the top quintile of cumulative exposure, with a 15 year lag, was 1.27 (0.94-1.69), with a positive trend of increasing SIR with increasing exposure (p=0.002). SIRs are under-estimated because breast cancer incidence in the whole cohort was under-ascertained, due to incomplete response and lack of complete coverage by state cancer registries. In internal nested case-control analyses of those with interviews (complete cancer ascertainment), controlling for reproductive risk factors, a positive exposure-response was found with the log of cumulative exposure with a 15-year lag (p=0.0005). The odds ratio by quintile of cumulative exposure were 1.00 (0 exposure due to 15 year lag), 1.06, 0.99, 1.24, 1.42, and 1.87. Conclusions: Our data suggest that ETO is associated with breast cancer, but a causal interpretation is weakened due to some inconsistencies in exposure-response trends and possible biases due to non-response and incomplete cancer ascertainment.
KW - breast
KW - breast cancer
KW - carcinogens
KW - disease incidence
KW - epidemiology
KW - ethylene oxide
KW - exposure
KW - human diseases
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - women
KW - Ohio
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - breasts
KW - cancers
KW - oxirane
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033151990&site=ehost-live&scope=site
UR - http://ipsapp009.kluweronline.com/content/getfile/4563/53/6/abstract.htm
UR - email: nsteenl@sph.emory.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Research science, regulatory science, and nutrient databases: achieving an optimal convergence Capstone Lecture.
AU - Ershow, A. G.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2003///
VL - 16
IS - 3
SP - 255
EP - 268
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Ershow, A. G.: Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 6701 Rockledge Drive, Suite 10-193, MSC 7956, Bethesda, MD 20892-7956, USA.
N1 - Accession Number: 20033113469. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - The compelling practical applications of nutrient databases, and the technical challenges in their development, often divert attention from their underlying research basis. Nutrient databases are, in fact, the publications of research projects that draw on the methodology of analytical chemistry, sampling statistics, and information technology in order to answer a core question: "What is the nutrient content of the food supply?" The responsibility for addressing this question, and for conducting the ensuing research, is typically assigned to governmental entities, especially for databases that are reflective of national food supplies. This responsibility reflects the key role of nutrient data in public health decision-making. At their best, nutrient databases can represent an optimal convergence of the characteristics of both "research science," which seeks to increase knowledge of natural phenomena and processes, and "regulatory science," which provides the knowledge base needed for policy-making and other government work. These two categories of research have many commonalities, such as their scientific methodology, even though they differ in their sites of performance and affiliated institutions, their operational procedures, and their standards of accountability. A good example of this convergence is found in the National Food and Nutrient Analysis Program and its various ancillary projects (databases on fluoride, choline, phytonutrients, Native American/Alaska Native foods, commodity foods, and dietary supplements). Confirmed validity of the findings, enhanced trust in the results, strengthened political and public support, and funding that underwrites the capacity for high scientific standards, are all potential benefits of acknowledging the simultaneous research and regulatory science aspects of nutrient databases.
KW - databases
KW - decision making
KW - food supply
KW - nutrient content
KW - nutrient databanks
KW - nutrition
KW - public health
KW - research
KW - choice
KW - data banks
KW - studies
KW - Research (AA500)
KW - Information and Documentation (CC300)
KW - Food Economics (EE116) (New March 2000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033113469&site=ehost-live&scope=site
UR - email: ershowa@nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - What's new on nutrition labeling at the United States Food and Drug Administration?
AU - Brandt, M. B.
AU - LeGault, L. A.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2003///
VL - 16
IS - 3
SP - 383
EP - 393
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Brandt, M. B.: Office of Nutritional Products, Labeling and Dietary Supplements (HFS-840), Center for Food Safety and Applied Nutrition, USA Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033113485. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - The manuscript provides an overview of food labeling activities of the United States (USA) Food and Drug Administration (FDA). Highlights include: FDA will proceed with final rulemaking on trans fatty acid labeling after review of the National Academy of Sciences (NAS) Macronutrient Report; FDA, United States Department of Agriculture (USDA), and Health Canada are funding a 24-month NAS study on Dietary Reference Intakes in Nutrition Labeling to provide information that can be considered in the development of reference values for labeling in the USA and Canada; In March of 2002, FDA published a rule that proposes to amend the regulations to update the names and nutrition labeling values of the 20 most frequently consumed raw fruits, vegetables, and fish in the USA and to revise the guidelines for the voluntary nutrition labeling of these raw foods; For over 20 years, FDA has used the Food Label and Package Survey (FLAPS) to monitor the industry response to food label regulations. FLAPS is the only large-scale USA survey that routinely reviews food label information representative of the nation's food supply; Nutrition labeling databases are collections of nutrient data for specific products or commodities used to support nutrition label values. While selection of the source of the data used to calculate nutrition labeling values is the prerogative of the manufacturer, FDA recommends that the nutrient values for nutrition labeling be based on product composition as determined by laboratory analysis. Restaurants using claims must provide nutrition information relevant to the claim and may determine nutrient levels by nutrient databases, cookbooks, analyses, and by other reasonable bases that provide assurance that the food or meal meets the nutrient requirements for a claim.
KW - databases
KW - guidelines
KW - nutrient databanks
KW - nutrients
KW - nutrition information
KW - raw foods
KW - trans fatty acids
KW - data banks
KW - nutrition labelling
KW - recommendations
KW - Information and Documentation (CC300)
KW - Food Economics (EE116) (New March 2000)
KW - Marketing and Distribution (EE700)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033113485&site=ehost-live&scope=site
UR - email: mary.bender@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concentration of inorganic arsenic in samples of white rice from the United States.
AU - Lamont, W. H.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2003///
VL - 16
IS - 6
SP - 687
EP - 695
CY - London; UK
PB - Academic Press
SN - 0889-1575
AD - Lamont, W. H.: Food and Drug Administration, Office of Plant and Dairy Foods and Beverages, Elemental Research Branch, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033196829. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 7440-38-2. Subject Subsets: Soils & Fertilizers; Rice
N2 - Concentrations of inorganic arsenic were determined by ion-trap, electrospray, mass spectrometry in 40 samples of white rice, which were collected in the United States. Inorganic arsenic was qualitatively present in all samples. The quantitative range of concentrations of inorganic arsenic extended from <0.025 to 0.271 µg/g (wet-mass basis). The extremes of the range were validated with acceptable analytical recoveries of fortifications. Statistical bounds of the range were established and assessed. The distribution of concentrations over the observed range was characterized statistically with an empirical lognormal probability distribution function. For the samples of white rice, a geometric mean corresponding to 0.112 µg/g and a geometric standard deviation equivalent to 0.055 µg/g of inorganic arsenic were derived from the empirical lognormal function.
KW - arsenic
KW - chemical composition
KW - food contamination
KW - mineral content
KW - pesticide residues
KW - rice
KW - spatial distribution
KW - statistical analysis
KW - USA
KW - Oryza
KW - Oryza sativa
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Oryza
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - paddy
KW - statistical methods
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Soil Chemistry and Mineralogy (JJ200)
KW - Soil Fertility (JJ600)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Industrial Wastes and Effluents (XX400)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033196829&site=ehost-live&scope=site
UR - email: william.lamont@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.
AU - Costa, G. G. da
AU - Churchwell, M. I.
AU - Hamilton, L. P.
AU - Tungeln, L. S. von
AU - Beland, F. A.
AU - Marques, M. M.
AU - Doerge, D. R.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2003///
VL - 16
IS - 10
SP - 1328
EP - 1337
CY - Washington; USA
PB - American Chemical Society
SN - 0893-228X
AD - Costa, G. G. da: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043106015. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Acrylamide (AA) is a high production volume chemical with many industrial uses; however, recent findings of ppm levels in starchy foods cooked at high temperature have refocused worldwide attention on the neurotoxicity, germ cell mutagenicity, and carcinogenicity of AA. Oxidative metabolism of AA to its epoxide metabolite, glycidamide (GA), has been observed in experimental animals and humans and may be associated with many of the toxic effects of AA exposure, including formation of N7-(2-carbamoyl-2-hydroxyethyl)guanine (N7-GA-Gua) in vivo. This paper describes the characterization of two new GA-derived DNA adducts formed in vitro, N3-(2-carbamoyl-2-hydroxyethyl)adenine (N3-GA-Ade) and N1-(2-carboxy-2-hydroxyethyl)-2′-deoxyadenosine. A sensitive method for quantification of N7-GA-Gua and N3-GA-Ade, based on LC with tandem mass spectrometry and isotope dilution, was developed and validated for use in measuring DNA adduct formation in selected tissues of adult and whole body DNA of 3 day old neonatal mice treated with AA and GA. In adult mice, DNA adduct formation was observed in liver, lung, and kidney with levels of N7-GA-Gua around 2000 adducts/108 nucleotides and N3-GA-Ade around 20 adducts/108 nucleotides. Adduct levels were modestly higher in adult mice dosed with GA as opposed to AA; however, treatment of neonatal mice with GA produced 5-7-fold higher whole body DNA adduct levels than with AA, presumably reflective of lower oxidative enzyme activity in newborn mice. DNA adduct formation from AA treatment in adult mice showed a supralinear dose-response relationship, consistent with saturation of oxidative metabolism at higher doses. These results increase our understanding of the mutagenic potential of GA and provide further evidence for a genotoxic mechanism in AA carcinogenesis.
KW - acrylamides
KW - animal models
KW - carcinogens
KW - in vitro
KW - laboratory animals
KW - oxidation
KW - toxicity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - glycidamide
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043106015&site=ehost-live&scope=site
UR - email: ddoerge@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The protective effects of propolis on hepatic injury and its mechanism.
AU - Seo KyungWon
AU - Park Mijung
AU - Song YeonJung
AU - Kim SungJin
AU - Yoon KwangRo
JO - Phytotherapy Research
JF - Phytotherapy Research
Y1 - 2003///
VL - 17
IS - 3
SP - 250
EP - 253
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0951-418X
AD - Seo KyungWon: Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyunggu, Seoul 122-020, Korea Republic.
N1 - Accession Number: 20033075801. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 50812-37-8, 9009-62-5, 62213-32-5. Subject Subsets: Medical & Veterinary Entomology; Aromatic & Medicinal Plants; Tropical Diseases
N2 - Propolis (PP) is a sticky substance that is collected from plants by honeybees. The purpose of this study was to investigate the protective effects of PP on hepatotoxicity induced by acetaminophen (AA, paracetamol) and the mechanism of its hepatoprotective effect. In rat hepatocyte culture, pretreatment with PP (1, 10, 100, 200 and 400 µg/mL, 24 h) significantly decreased the cytotoxicity of AA (0.5 mM) in a dose-dependent manner. In mice, pretreatment with PP (10 and 25 mg/kg, p.o., 7 days) also decreased the mortality and the incidence and severity of hepatic necrosis induced by AA (400 mg/kg, i.p.). After treatment with PP for 7 days, the hepatic enzyme activities of cytochrome P450 monooxygenases (P450s), UDP-glucuronyltransferase, phenolsulphotransferase (PST), glutathione S-transferase (GST) were measured in both rats and mice. In rats, PP (50 and 100 mg/kg, p.o.) decreased the activity of P4502E1, but significantly increased the activities of GST and PST. On the other hand, in mice treated with PP (10 and 25 mg/kg, p.o.), the activities of P4501A2, 2B1, 3A4 and 2E1 were dramatically inhibited, and the activity of PST was significantly enhanced. These results suggest that PP has a protective effect on hepatic injury, and that its effect may be explained by inhibition of phase I enzymes and induction of phase II enzymes.
KW - animal models
KW - cell cultures
KW - cytotoxicity
KW - enzyme activity
KW - glutathione transferase
KW - hepatoprotective properties
KW - hexosyltransferases
KW - hive products
KW - liver
KW - liver diseases
KW - necrosis
KW - propolis
KW - transferases
KW - unspecific monooxygenase
KW - Korea Republic
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - anti-hepatotoxic properties
KW - antihepatotoxic properties
KW - aryl hydrocarbon hydroxylase
KW - aryl sulfotransferase
KW - flavoprotein-linked monooxygenase
KW - ligandin
KW - South Korea
KW - UDP-glucuronosyltransferase
KW - Non-food/Non-feed Animal Products (SS100)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
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UR - email: kwseo@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Child nutrition programs legislation: past and present.
AU - Stitzel, K. F.
JO - Topics in Clinical Nutrition
JF - Topics in Clinical Nutrition
Y1 - 2003///
VL - 19
IS - 1
SP - 9
EP - 19
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0883-5691
AD - Stitzel, K. F.: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, 200 Independence Ave, SW, Room 738-G, Washington, DC 20201, USA.
N1 - Accession Number: 20043047853. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - Every 5 years, the Special Supplemental Food Program for Women, Infants, and Children (WIC) and child nutrition programmes are scheduled for reauthorization. Child nutrition programmes provide cash, commodity, and other assistance under 3 major federal laws: the National School Lunch Act (originally enacted in 1946 and renamed the Richard B. Russell National School Lunch Act in 1999), the Child Nutrition Act (originally enacted in 1966), and sections 32 and 416 of the Agricultural Act. This article highlights the historical and legislative chronology of the child nutrition and WIC programmes, outlines key issues and proposed legislation, discusses the role nutrition professionals can play, and suggests a possible timeline for the reauthorization.
KW - children
KW - history
KW - legislation
KW - nutrition programmes
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - nutrition programs
KW - History and Biography (BB500)
KW - Laws and Regulations (DD500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043047853&site=ehost-live&scope=site
UR - email: KStitzel@OSOPHS.DHHS.GOV
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of lead in 55 brands of dietary calcium supplements by graphite furnace atomic absorption spectrometry after microwave digestion.
AU - Kim Meehye
AU - Kim Changmin
AU - Song Insang
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 2
SP - 149
EP - 153
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Kim Meehye: Department of Food Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20033027674. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 7440-70-2, 7439-92-1. Subject Subsets: Dairy Science; Tropical Diseases; Human Nutrition
N2 - The lead (Pb) contents of calcium (Ca) supplements available in Korea Republic were determined by graphite furnace atomic absorption spectrometry using Zeeman background correction and peak area mode. All samples were microwave-digested in concentrated HNO3. Ammonium dihydrogen phosphate and magnesium nitrate were used as matrix modifiers. 55 brands of Ca supplements were classified into 7 categories based on the major composite: bone, milk, oyster/clam shell, egg shell, algae, shark cartilage and chelated. The mean Pb contents of Ca supplements were 1.1 µg/g (coefficient of variation 5.7%), ranging from n.d. (not detected) to 6.7 µg/g. Ca supplements made of bone have the highest Pb contents (2.3 µg/g) with a wide range (0.1-6.7 µg/g). The results were similar to those reported in other countries. The Koreans mean daily intakes of Pb from the supplement could be about 5 µg (mean Pb concentration 1.1 µg/g × mean daily intake 4.5 g), taking 2% of provisional tolerable daily intake that the FAO/WHO Joint Food Additive and Contaminants Committee has set to evaluate its safety. However, measures to prevent potentials of Pb toxicity from overtaking some Ca supplements should be considered.
KW - bones
KW - calcium
KW - cartilage
KW - chemical analysis
KW - clams
KW - contamination
KW - egg shell
KW - intake
KW - lead
KW - milk
KW - mineral supplements
KW - oysters
KW - sharks
KW - toxic substances
KW - Korea Republic
KW - algae
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - plants
KW - aquatic plants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Chondrichthyes
KW - fishes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - poisons
KW - South Korea
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033027674&site=ehost-live&scope=site
UR - email: meehkim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of gamma- and electron-beam irradiation on semi-rigid amorphous polyethylene terephthalate copolymers.
AU - Komolprasert, V.
AU - McNeal, T. P.
AU - Begley, T. H.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 5
SP - 505
EP - 517
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Komolprasert, V.: Division of Food Processing and Packaging, US Food and Drug Administration, National Center for Food Safety and Technology, Illinois Institute of Technology, 6502 S. Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033097394. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 75-07-0, 9002-88-4.
N2 - Two semi-rigid amorphous polyethylene terephthalate copolymer materials (in both sheet and powder forms) containing 3 and 31% 1,4-cyclohexane dimethanol (CHDM) were irradiated at 5, 25 and 50 kGy at ambient temperature with a 60Co radiator or an electron-beam accelerator. After irradiation, volatiles were determined using static headspace sampling with capillary gas chromatography and mass selective detection or flame ionization detection (HS/GC/MSD or FID). Non-volatiles were extracted with 10% aqueous ethanol and 100% n-heptane food-simulating solvents, maintained at 40°C for up to 10 days. The non-volatiles in the materials and those migrating into the food-simulating solvents were determined by HPLC with ultraviolet and/or photodiode array detection. The results obtained from the HS/GC/MSD suggest that no new chemicals were detected by either gamma- or e-beam irradiation when compared with non-irradiated specimens. The major volatiles in the copolymers were acetaldehyde and 2-methyl-1,3-dioxolane. The concentrations of acetaldehyde increased, while the concentrations of 2-methyl-1,3-dioxolane decreased after irradiation. The results of analysis for non-volatiles showed that irradiation did not produce any new detectable non-volatile chemicals. A 5 kGy dose had no detectable effect on either copolymer. The 25 and 50 kGy doses had slightly different effects with respect to gamma- and e-beam irradiation on low MW oligomers. However, these increased doses did not significantly affect migration. The concentration of most low molecular weight oligomers migrating into 10% ethanol and 100% heptane was ≤2 ng/g of each oligomer for both copolymers. The cyclic trimer migrating from the 3% CHDM copolymer was approximately 4 ng/g; it was 3 ng/g for the 31% CHDM copolymer. The overall results suggest that irradiation significantly increased the levels of acetaldehyde but had no effect on non-volatile compounds migrating into food simulants.
KW - acetaldehyde
KW - analytical methods
KW - electrons
KW - extraction
KW - food contamination
KW - food packaging
KW - gamma radiation
KW - gas chromatography
KW - HPLC
KW - ionizing radiation
KW - irradiation
KW - migration
KW - packaging materials
KW - polyethylene
KW - polymers
KW - solvents
KW - volatile compounds
KW - analytical techniques
KW - food contaminants
KW - gamma rays
KW - headspace analysis
KW - high performance liquid chromatography
KW - mass selective detection
KW - non-volatile compounds
KW - oligomers
KW - polythene
KW - volatile constituents
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033097394&site=ehost-live&scope=site
UR - email: Vanee.Komolprasert@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of nitrate and nitrite contents of vegetables grown in Korea.
AU - Chung, S. Y.
AU - Kim, J. S.
AU - Kim, M.
AU - Hong, M. K.
AU - Lee, J. O.
AU - Kim, C. M.
AU - Song, I. S.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 7
SP - 621
EP - 628
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Chung, S. Y.: Department of Food Evaluation, Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20033134794. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Postharvest Research; Human Nutrition; Potatoes; Soyabeans; Horticultural Science
N2 - A scientific basis for the evaluation of the risk to public health arising from excessive dietary intake of nitrate in Korea is provided. The nitrate (NO3-) and nitrite (NO2-) contents of various vegetables (Chinese cabbage, radish, lettuce, spinach, soyabean sprouts, onion, pumpkin, green onion, cucumber, potato, carrot, garlic, green pepper, cabbage and Allium tuberosum Roth known as Crown daisy) are reported. Six hundred samples of 15 vegetables cultivated during different seasons were analysed for nitrate and nitrite by ion chromatography and ultraviolet spectrophotometry, respectively. No significant variance in nitrate levels was found for most vegetables cultivated during the summer and winter harvests. The mean nitrates level was higher in A. tuberosum Roth (5150 mg/kg) and spinach (4259 mg/kg), intermediate in radish (1878 mg/kg) and Chinese cabbage (1740 mg/kg), and lower in onion (23 mg/kg), soyabean sprouts (56 mg/kg) and green pepper (76 mg/kg) compared with those in other vegetables. The average nitrite contents in various vegetables were about 0.6 mg/kg, and the values were not significantly different among most vegetables. It was observed that nitrate contents in vegetables varied depending on the type of vegetables and were similar to those in vegetables grown in other countries. From the results of our studies and other information from foreign sources, it can be concluded that it is not necessary to establish limits of nitrates contents of vegetables cultivated in Korea due to the co-presence of beneficial elements such as ascorbic acid and α-tocopherol which are known to inhibit the formation of nitrosamine.
KW - cabbages
KW - carrots
KW - Chinese cabbages
KW - cucumbers
KW - food safety
KW - garlic
KW - lettuces
KW - nitrates
KW - nitrites
KW - onions
KW - potatoes
KW - pumpkins
KW - radishes
KW - soyabeans
KW - spinach
KW - wild relatives
KW - Korea Republic
KW - Allium
KW - Allium sativum
KW - Allium tuberosum
KW - Brassica
KW - Brassica oleracea var. capitata
KW - Capsicum
KW - Cucumis sativus
KW - Cucurbita
KW - Daucus carota
KW - Glycine (Fabaceae)
KW - Lactuca sativa
KW - Raphanus sativus
KW - Solanum tuberosum
KW - Spinacia oleracea
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Allium
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - Brassica oleracea
KW - Brassica
KW - Solanaceae
KW - Solanales
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - Raphanus
KW - Solanum
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - Araliales
KW - Capparales
KW - gherkins
KW - South Korea
KW - soybeans
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033134794&site=ehost-live&scope=site
UR - email: sychung@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction.
AU - Shin, M. H.
AU - Hong, M. K.
AU - Kim, W. S.
AU - Lee, Y. J.
AU - Jeoung, Y. C.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 9
SP - 793
EP - 796
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Shin, M. H.: Busan Regional Food and Drug Administration, Busan 608-829, Korea Republic.
N1 - Accession Number: 20033176119. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Human Nutrition
N2 - A new analogue of sildenafil was discovered to have been added illegally to a functional food marketed for penile erectile dysfunction. The structure of the analogue was established by various NMR spectroscopic techniques (including DEPT, COSY, TOCSY, HMQC, HMBC). Because of the addition of a methylene group to sildenafil, the main ingredient of Viagra, it was given the name homosildenafil, and this has never been reported previously. An analytical method using HPLC was proposed. Homosildenafil was added as a new inspection item and other foods have since been discovered to contain it.
KW - analogues
KW - chemical structure
KW - food additives
KW - food inspection
KW - functional foods
KW - analogs
KW - homosildenafil
KW - sildenafil
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033176119&site=ehost-live&scope=site
UR - email: mhshin72@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of polypropylene film as a barrier to migration from recycled paperboard packaging to fatty and high-moisture food.
AU - Song, Y. S.
AU - Begley, T.
AU - Paquette, K.
AU - Komolprasert, V.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 9
SP - 875
EP - 883
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Song, Y. S.: Division of Food Processing and Packaging, US Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033176129. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 87-86-5, 9003-07-0.
N2 - The capability of a polypropylene (PP) film barrier to prevent migration of residual contaminants from recycled paperboard into food simulants was studied. Anthracene, benzophenone, methyl stearate and pentachlorophenol were chosen as chemical surrogates to represent classes of contaminants likely to be found in recycled paper/paperboard. Each surrogate was spiked into a test specimen made of 7 thin virgin paper layers at concentrations of 1-50 mg kg-1. Test specimen were dried, stacked and sandwiched with PP films, laminated with PP film and then subjected to migration experiments using a compression cell maintained at 100°C for 2 hours. The concentration of the surrogates in the test specimen and in 95% ethanol, isopropanol and 10% ethanol food-simulating solvents was determined by gas chromatography with flame ionization and electron capture detection. The results showed that although the concentrations of the surrogates in the food simulants decreased with an increase in PP film thickness, they were still high and generally resulted in dietary concentrations >0.5 µg kg-1, the level that US Food and Drug Administration would equate with negligible risk for a contaminant migrating from food packaging. Only at the lowest spiking level (1 mg kg-1 benzophenone) did migration from the paperboard through a 0.127-mm PP film result in a dietary concentration of ≤0.5 µg kg-1. Therefore, it can be concluded that for an extended time at 100°C, PP would not be an acceptable barrier to migration of contaminants that are expected to be in post-consumer paper/paperboard.
KW - film
KW - food contamination
KW - food packaging
KW - packaging materials
KW - paperboard
KW - pentachlorophenol
KW - polypropylenes
KW - anthracene
KW - benzophenone
KW - food contaminants
KW - methyl stearate
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033176129&site=ehost-live&scope=site
UR - email: yoon.song@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of 1,3-dichloropropanol in soy and related sauces by using gas chromatography/mass spectrometry.
AU - Nyman, P. J.
AU - Diachenko, G. W.
AU - Perfetti, G. A.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 10
SP - 903
EP - 908
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Nyman, P. J.: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033195504. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Postharvest Research; Soyabeans
N2 - A gas chromatography-mass spectrometry (GC-MS) method for 3-monochloropropane-1,2-diol (3-MCPD) in foods and food ingredients was modified for the determination of 1,3-dichloro-2-propanol (1,3-DCP) in soya and related sauces. The method was validated by using a blank soya sauce. The detection limit, quantitation limit and recoveries were determined, and identities were confirmed by mass spectrometry on the basis of analyses of test portions spiked with 1,3-DCP at 10, 25, 50 and 100 ng/g. The spiked test portions were quantitated by using an internal standard calibration curve. For the spiked test portions, the mean internal standard-corrected recovery for 1,3-DCP was 100% with a relative standard deviation of 1.32%. The limits of detection and quantitation were determined as 0.055 and 0.185 ng/g, respectively. The method also was compared with a headspace GC-MS method recently developed by the UK's Central Science Laboratory. Results from the method comparison showed that the recoveries for the spiked test portions, as well as the amounts of 1,3-DCP found in the retail products, were comparable.
KW - alcohols
KW - analytical methods
KW - chemical composition
KW - detection
KW - food analysis
KW - food contamination
KW - GC-MS
KW - quantitative analysis
KW - sauces
KW - soya sauce
KW - soyabean products
KW - toxic substances
KW - 1,3-dichloro-2-propanol
KW - analytical techniques
KW - food contaminants
KW - gas chromatography-mass spectrometry
KW - poisons
KW - soy sauce
KW - soybean products
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033195504&site=ehost-live&scope=site
UR - email: pnyman@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of chloropropanols in soy sauces and related products.
AU - Nyman, P. J.
AU - Diachenko, G. W.
AU - Perfetti, G. A.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 10
SP - 909
EP - 915
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Nyman, P. J.: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033195505. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Postharvest Research; Soyabeans
N2 - A survey of soya sauces and related products available in the USA (in Baltimore, Maryland and Washington, District of Columbia) was conducted to determine the levels of 3-monochloropropane-1,2-diol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) in these products. 55 retail samples were purchased and analysed for 3-MCPD. 3-MCPD determinations were made according to a gas chromatography-mass spectrometry method validated by a collaborative trial. 85% of the samples analysed contained greater than the detection limit of 0.005 ppm (µg/g) for 3-MCPD. 33% contained greater than 1 ppm; the highest level was 876 ppm. 39 of the samples analysed for 3-MCPD also were analysed for 1,3-DCP by using a modified method developed and validated in-house. 56% of the samples analysed for 1,3-DCP contained greater than the detection limit of 0.055 ppb (ng/g) for 1,3-DCP; the highest level was 9.8 ppm. The products manufactured in Asia contained the highest chloropropanol levels.
KW - alcohols
KW - chemical composition
KW - food analysis
KW - food contamination
KW - soya sauce
KW - soyabean products
KW - surveys
KW - toxic substances
KW - District of Columbia
KW - Maryland
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - 1,3-dichloro-2-propanol
KW - 3-monochloropropane-1,2-diol
KW - chloropropanols
KW - food contaminants
KW - poisons
KW - soy sauce
KW - soybean products
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033195505&site=ehost-live&scope=site
UR - email: pnyman@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Migration of volatile degradation products into ozonated water from plastic packaging materials.
AU - Song, Y. S.
AU - Al-Taher, F.
AU - Sadler, G.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2003///
VL - 20
IS - 10
SP - 985
EP - 994
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Song, Y. S.: Division of Food Processing and Packaging, US Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033195513. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 10028-15-6, 9002-88-4, 9003-07-0.
N2 - Migration of volatile degradation products from poly(ethylene terephthalate) (PET) and high-density polyethylene (HDPE) bottles, polypropylene (PP) caps and ethyl vinyl acetate (EVA) liners into ozonated water was measured. Polymer strips were immersed in deionized and distilled water with ozone concentrations of 0.5, 2.5 and/or 5 mg kg-1 inside 35-ml vials, which were clamp-sealed and stored at 40°C for 10 days. A purge-and-trap unit was developed to extract volatile products from the ozonated water in vials. The extractables were trapped in an adsorbent tube and analysed using a GC-MS coupled with an automated thermal desorber (ATD). Mass spectra were interpreted by comparison with a NIST mass spectral library, and an internal standard method was used to quantify the extractables of interest. Several volatile compounds found in ozonated water that had been in contact with PP, EVA and HDPE polymers included butanal, pentanal, hexanal, heptanal, octanal, nonanal, 2,2-dimethyl propanal, 3-hexanone, 2-hexanone and heptanone. These compounds could cause off-taste and off-odour with a low organoleptic threshold. In general, the concentrations of these volatile compounds increased with an increased exposure to ozone. The highest concentration found was 14.1±0.6 µg kg-1 for hexanal with a 5 mg kg-1 ozone treatment of PP caps. Even at a treatment level of 5 mg kg-1 ozone, which is greater than 10 times the current regulatory limits for bottled water, the extractables migrating from those polymers were within the levels permitted by the FDA. For the PET sample, no significant peaks were observed before or after ozonation. These results imply that PP caps containing EVA liners may be major sources of off-odour and taste in ozonated bottled water.
KW - bottles
KW - drinking water
KW - food contamination
KW - food packaging
KW - linings
KW - migration
KW - ozone
KW - packaging materials
KW - plastics
KW - polyethylene
KW - polypropylenes
KW - volatile compounds
KW - ethyl vinyl acetate
KW - food contaminants
KW - liners
KW - ozonated water
KW - polyethylene terephthalate
KW - polythene
KW - volatile constituents
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033195513&site=ehost-live&scope=site
UR - email: yoon.song@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternal immunization: US FDA regulatory considerations.
AU - Gruber, M. F.
A2 - Vicari M.
A2 - Englund J.
A2 - Glezen P.
A2 - Greenwood B.
A2 - Rubin F.
A2 - Trannoy E.
T3 - Special Issue: Protection of Newborns through Maternal Immunization
JO - Vaccine
JF - Vaccine
Y1 - 2003///
VL - 21
IS - 24
SP - 3487
EP - 3491
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Gruber, M. F.: Center for Biologics Evaluation and Research (CBER), US FDA, Woodmont Office Complex 1 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20033132997. Publication Type: Journal Article; Conference paper. Note: Special Issue: Protection of Newborns through Maternal Immunization Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Vaccination of pregnant women provides important health benefits to both, mother and infant, and has been an important disease prevention strategy in these two groups. While most vaccines currently licensed in the US are not indicated for use during pregnancy, depending on the vaccine, vaccination programs do frequently include pregnant women. In addition, recent emphasis has been placed on maternal immunization strategies to protect young infants from severe infections. Currently, unless the vaccine is specifically indicated four maternal immunization, no data are collected regarding the vaccine's safety in pregnant women prior to licensure. However, more females of childbearing age participate in clinical trials and a broad range of novel vaccine products are in development indicated for adolescents and adults. Thus, there is increasing concern for the unintentional exposure of an embryo/fetus before information is available regarding the potential risk versus benefit of the vaccine. Since pregnant women are usually excluded from participation in clinical trials, conclusions regarding developmental risk at the time of licensure are frequently based solely on data derived from developmental toxicity studies in animal models. This paper will review regulatory, preclinical and clinical issues as they pertain to development programs for vaccines intended for vaccination during pregnancy.
KW - disease prevention
KW - immunization
KW - infectious diseases
KW - pregnancy
KW - regulations
KW - reviews
KW - risk
KW - toxicity
KW - vaccination
KW - vaccines
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - gestation
KW - immune sensitization
KW - rules
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033132997&site=ehost-live&scope=site
UR - email: gruber@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Correlates of immunity for pneumococcal conjugate vaccines.
AU - Lee, L. H.
AU - Frasch, C. E.
AU - Falk, L. A.
AU - Klein, D. L.
AU - Deal, C. D.
JO - Vaccine
JF - Vaccine
Y1 - 2003///
VL - 21
IS - 17/18
SP - 2190
EP - 2196
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Lee, L. H.: Division of Vaccines and Related Products Applications, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-475, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20033097577. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 308067-58-5.
N2 - The purpose of the NIAID/FDA joint workshop, "correlates of immunity for pneumococcal conjugate vaccines (PCVs)," was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Animal and clinical data support functional antibody as the basis for protection, but IgG antibody concentration has conventionally been the principle immunologic parameter for non-inferiority comparisons. No consensus for a pre-defined threshold antibody level was reached. Affinity maturation may contribute to protection, but its role has not been established. Opsonophagocytic activity, avidity and immunologic memory are important secondary measures to characterise functional antibody and long-term protective responses. Immunologic memory may also be useful for evaluation of new vaccine serotypes. More definitive qualitative and quantitative immunogenicity criteria for use by National Control Authorities still need to be established.
KW - antibodies
KW - bacterial diseases
KW - conjugate vaccines
KW - disease models
KW - human diseases
KW - IgG
KW - immune response
KW - immunity
KW - immunization
KW - in vitro
KW - phagocytosis
KW - reviews
KW - vaccination
KW - man
KW - Streptococcus pneumoniae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033097577&site=ehost-live&scope=site
UR - email: leel@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors for bronchiolitis-associated deaths among infants in the United States.
AU - Holman, R. C.
AU - Shay, D. K.
AU - Curns, A. T.
AU - Lingappa, J. R.
AU - Anderson, L. J.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2003///
VL - 22
IS - 6
SP - 483
EP - 489
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Holman, R. C.: Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033116470. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Public Health
N2 - Background. Risk factors for bronchiolitis deaths have not been described on a national level. We examined the epidemiology of and identified risk factors for bronchiolitis-associated deaths among infants in the United States. Methods. Multiple cause-of-death and linked birth/infant death data for 1996 through 1998 were used to examine bronchiolitis-associated infant deaths. Risk factors were assessed by comparing infants who died with bronchiolitis and surviving infants. Results. During 1996 through 1998 there were 229 bronchiolitis infant deaths, resulting in an average annual infant mortality rate of 2.0 per 100 000 live births. The majority (55%) of infant deaths occurred among infants ages 1 through 3 months. The bronchiolitis mortality rate was highest among infants weighing <1500 g at birth (VLBW) as compared with infants weighing 1500 to 2499 g (LBW) and ≥2500 g at birth (29.8, 6.4 and 1.3 per 100 000 live births, respectively). Sixty-three percent of bronchiolitis deaths were among infants weighing ≥2500 g. VLBW and LBW infants remained at an increased risk of dying with bronchiolitis after controlling for other risk factors. Other risk factors included increasing birth order, low 5-min Apgar score, young maternal age, unmarried mother and tobacco use during pregnancy. Conclusions. VLBW and LBW infants are at increased risk of dying with bronchiolitis, even when taking into account other risk factors. Although infants weighing <2500 g at birth are at increased risk for dying with bronchiolitis, the majority of bronchiolitis deaths occur among infants of normal birth weight.
KW - birth weight
KW - bronchiolitis
KW - epidemiology
KW - human diseases
KW - infant mortality
KW - infants
KW - low birth weight infants
KW - respiratory diseases
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033116470&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki syndrome hospitalizations in Ireland, 1996 through 2000.
AU - Lynch, M.
AU - Holman, R. C.
AU - Mulligan, A.
AU - Belay, E. D.
AU - Schonberger, L. B.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2003///
VL - 22
IS - 11
SP - 959
EP - 962
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Lynch, M.: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20033208746. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Objective. To describe the epidemiologic characteristics and estimate the incidence of Kawasaki syndrome (KS) among children in Ireland. Methods. Hospital discharge records with a KS diagnosis among patients <18 years of age were examined using Ireland's Hospital In-Patient Enquiry database for 1996 through 2000. Results. During the study period 265 hospitalizations associated with KS among children <18 years of age were recorded in Ireland. Of those, 194 (73%) occurred among children <5 years of age. The median age of patients at admission was 2 years. The average annual KS hospitalization rate for children <5 years of age was 15.2 per 100 000 children, and among that group the hospitalization rate was higher for infants <1 year of age than for children 1 to 4 years of age (19.7 and 16.0 per 100 000 children, respectively). Most KS hospitalizations occurred among children <5 years of age and among boys. The highest monthly number of hospitalizations occurred during the months of November through January. No deaths associated with KS were reported among hospitalized children. Conclusion. Hospital discharge data provide useful information on the epidemiology of KS in Ireland. The hospitalization rate for KS in Ireland is similar to rates in the United States and may be higher than those in other European countries, although the European studies differ in methodologies and time periods.
KW - boys
KW - children
KW - disease incidence
KW - epidemiology
KW - girls
KW - human diseases
KW - infants
KW - Kawasaki disease
KW - Irish Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Eire
KW - mucocutaneous lymph node syndrome
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033208746&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimation of k for the poly-k test with application to animal carcinogenicity studies.
AU - Moon, H. J.
AU - Ahn, H.
AU - Kodell, R. L.
AU - Lee, J. J.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 2003///
VL - 22
IS - 16
SP - 2619
EP - 2636
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0277-6715
AD - Moon, H. J.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033136525. Publication Type: Journal Article. Language: English. Number of References: 20 ref.
N2 - This paper extends the survival-adjusted Cochran-Armitage test in order to achieve improved robustness to a variety of tumour onset distributions. The Cochran-Armitage test is routinely applied for detecting a linear trend in the incidence of a tumour of interest across dose groups. To improve the robustness to the effects of differential mortality across groups, Bailer and Portier introduced the poly-3 test by a survival adjustment using a fractional weighting scheme for subjects not at full risk of tumour development. The performance of the poly-3 test depends on how closely it represents the correct specification of the time-at-risk weight in the data. Bailer and Portier further suggested that this test can be improved by using a general k reflecting the shape of the tumour onset distribution. In this paper, we propose a method to estimate k by equating the empirical lifetime tumour incidence rate obtained from the data based on the fractional weighting scheme to a separately estimated cumulative lifetime tumour incidence rate. This poly-k test with the statistically estimated k appears to perform better than the poly-3 test which is conducted without prior knowledge of the tumour onset distribution. Our simulation shows that the proposed method improves the robustness to various tumour onset distributions in addition to the robustness to the effects of mortality achieved by the poly-3 test. Large sample properties are shown via simulations to illustrate the consistency of the proposed method. The proposed methods are applied to analyse two real data sets. One is to find a dose-related linear trend on animal carcinogenicity, and the other is to test an effect of calorie restriction on experimental animals.
KW - animal models
KW - carcinogenesis
KW - disease course
KW - estimation
KW - mortality
KW - neoplasms
KW - statistical analysis
KW - cancers
KW - death rate
KW - disease progression
KW - statistical methods
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033136525&site=ehost-live&scope=site
UR - email: hmoon@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of food safety, quality, and other consumer statements on labels of processed, packaged foods.
AU - Brandt, M. B.
AU - Spease, C. J.
AU - June, G.
AU - Brown, A. M.
JO - Food Protection Trends
JF - Food Protection Trends
Y1 - 2003///
VL - 23
IS - 11
SP - 870
EP - 881
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 1541-9576
AD - Brandt, M. B.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20033196801. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology
N2 - The mission of the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration focuses on promoting and protecting the public's health by ensuring that the nation's food supply is safe, wholesome, sanitary, and honestly labelled. CFSAN monitors the food industry's response to food labelling regulations through the Food Label and Package Survey (FLAPS). FLAPS data characterize the presence of food safety and other information for the consumer. The labels of close to one-third of the food products sold in the United States include statements about refrigeration, but the words "to maintain safety" are not present, even though FDA guidance indicates the importance of including them. Consumers are concerned that labels contain information to alert allergic individuals to the presence of food allergens, but very few food labels voluntarily bear such information. Regulations do not require food manufacturers to provide information on bioengineered ingredients, and very few manufacturers voluntarily do so. Pasteurization is used to kill pathogens that could cause illness or death, and regulations require a warning statement on the label of juice products that have not been pasteurized or otherwise processed to prevent, reduce or eliminate pathogenic microorganisms. Over half of juices have a statement that they are pasteurized. Few foods contain information to cook foods thoroughly or to use a thermometer. The food label can be used as an educational tool and will be one of the primary vehicles to provide critical information to the consumer.
KW - consumer protection
KW - food hygiene
KW - food legislation
KW - food quality
KW - food safety
KW - labelling
KW - quality labelling
KW - standard labelling
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - labeling
KW - labels
KW - quality labeling
KW - standard labeling
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Policy and Planning (EE120)
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033196801&site=ehost-live&scope=site
UR - email: mbender@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ivan Parkin lecture: "on the trail of food safety - from the early days to the future".
AU - Zink, D. L.
JO - Food Protection Trends
JF - Food Protection Trends
Y1 - 2003///
VL - 23
IS - 11
SP - 904
EP - 906
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 1541-9576
AD - Zink, D. L.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant, Dairy Foods, and Beverages, College Park, Maryland, USA.
N1 - Accession Number: 20033196803. Publication Type: Journal Article; Conference paper. Language: English.
N2 - This paper deals with the origins of the discipline of food safety, the tools for accomplishing the goals of food safety, and the future priorities of food safety according to Donald L. Zink, Ph.D., an official of the US Food and Drug Administration.
KW - food safety
KW - history
KW - reviews
KW - History and Biography (BB500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033196803&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Equity of access to tertiary hospitals in Wales: a travel time analysis.
AU - Christie, S.
AU - Fone, D.
JO - Journal of Public Health Medicine
JF - Journal of Public Health Medicine
Y1 - 2003///
VL - 25
IS - 4
SP - 344
EP - 350
CY - Oxford; UK
PB - Oxford University Press
SN - 0957-4832
AD - Christie, S.: National Public Health Service for Wales, Mamhilad Park Estate, Pontypool NP4 0YP, UK.
N1 - Accession Number: 20043021520. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Background: The objective of the study was to investigate the implications for equity of geographical access for population subgroups arising from hypothetical scenarios of change in configuration of National Health Service tertiary hospital service provision located in Wales. Methods: For each of three scenarios, the status quo and centralization of services to one of two locations, we used a travel time road length matrix in geographical information software to calculate the proportion of the population living within 30, 60, 90 and 120 min travel of each hospital site and the associated mean, median and 90th percentile travel times. We analysed data for the total resident population of Wales, for residents aged 75 or more years, for residents of the most deprived 10 per cent of enumeration districts, and for residents of rural areas. Results: Centralization of services reduces geographical access for all population subgroups. Access varies between population subgroups, both between and within different scenarios of service configuration. A change in service configuration may improve access for one subgroup but reduce access for another. The interpretation may also vary according to whether the defined cut point for comparing access is based on short or long travel times. Measurements of absolute and relative access are sensitive to the assumed travel speeds. Conclusion: Access for the total population does not imply equity of access for subgroups of the population. Comparisons of access between scenarios are dependent on which measure of access is the indicator of choice. Results are sensitive to the road network travel speeds and further local validation may be necessary. This method can provide explicit information to health service planners on the effects on equity of access from a change in service configuration.
KW - distance travelled
KW - hospitals
KW - rural areas
KW - UK
KW - Wales
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - United Kingdom
KW - Health Services (UU350)
KW - Rural Health (VV550) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043021520&site=ehost-live&scope=site
UR - email: stephen.christie@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary ethinyl estradiol exposure during development causes increased voluntary sodium intake and mild maternal and offspring toxicity in rats.
AU - Ferguson, S. A.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Flynn, K. M.
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
Y1 - 2003///
VL - 25
IS - 4
SP - 491
EP - 501
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0892-0362
AD - Ferguson, S. A.: HFT-132/Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033137123. Publication Type: Journal Article. Language: English. Registry Number: 57-63-6, 7440-23-5, 7647-14-5. Subject Subsets: Human Nutrition
N2 - Exogenous estrogen exposure during development often results in behavioral masculinization and/or defeminization of genetic females. Genetic males may be defeminized, hypermasculinized or even demasculinized after similar treatment. Here, pregnant Sprague-Dawley rats consumed phytoestrogen-free diets containing 0, 1, 5 or 200 ppb EE2 beginning on gestational day (GD) 7. Offspring were weaned to the same maternal diet and maintained gonadally intact. There were mild effects on body weight and food consumption in dams of the 200 ppb group and their offspring weighed less at birth than those of the control group; however, gross assessments of nursing behavior were normal in all dietary groups. Postweaning, offspring of the 200 ppb group weighed less and consumed less food than controls. There were no EE2-related effects on open-field activity (tested at postnatal days (PND) 22-24, 43-45 and 64-66), play behavior (tested at PND 35), running wheel activity (PND 63-77) or intake of a 0.3% saccharin-flavored solution (PND 69-71). Intake of a 3.0% sodium chloride-flavored solution on PND 73-75 was increased in both male and female offspring of the 200 ppb group relative to same-sex controls, an effect that is reportedly estrogen mediated. Sodium chloride-flavored solution intake is a sexually dimorphic behavior for which female rats consume more than males. Here, while EE2 exposure had few effects on the conventional tests of sexually dimorphic behaviors, exposure to 200 ppb in the diet appeared to feminize genetic males and hyperfeminize genetic females with regard to sodium intake.
KW - animal models
KW - body weight
KW - diets
KW - ethinylestradiol
KW - food intake
KW - laboratory animals
KW - pregnancy
KW - salt
KW - sodium
KW - sodium chloride
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - NaCl
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033137123&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9X-483BXVH-1&_user=10&_handle=W-WA-A-A-AV-MsSAYZA-UUW-AUZWEECBVD-WAEDBEEBU-AV-U&_fmt=summary&_coverDate=08%2F31%2F2003&_rdoc=8&_orig=browse&_srch=%23toc%235126%232003%23999749995%23433592!&_cdi=5126&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d22ee4d802b7339d65f234b9a32188b4
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A human vaccine strain of lamb rotavirus (Chinese) NSP4 gene: complete nucleotide sequence and phylogenetic analyses.
AU - Mohan, K. V. K.
AU - Kulkarni, S.
AU - Glass, R. I.
AU - Bai ZhiSheng
AU - Atreya, C. D.
JO - Virus Genes
JF - Virus Genes
Y1 - 2003///
VL - 26
IS - 2
SP - 185
EP - 192
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0920-8569
AD - Mohan, K. V. K.: Section of Viral Pathogenesis and Vaccine Adverse Reactions, Laboratory of Pediatric and Respiratory Viral Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033094133. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Veterinary Science; Pig Science; Veterinary Science; Tropical Diseases
N2 - A lamb strain of rotavirus has recently been licensed for use in China as a live vaccine to prevent rotavirus diarrhoea in children. As rotavirus NSP4, especially the cytotoxic domain alone is considered to be associated with diarrhoea, we sequenced gene segment 10, which encodes NSP4, of lamb rotavirus. Comparative analyses was performed to identify differences from human rotavirus strains, that might be associated with attenuation, and to ascertain whether the lamb rotavirus gene fits among the NSP4 of other sequenced rotavirus strains. Our comparative nucleotide sequence analysis suggests its close identity (91.17% homology) with that of group-A equine rotavirus (strain HI23). Multiple alignment of the deduced amino acid sequence of lamb NSP4 with that of other group A rotaviruses demonstrated homology ranging from 63.42% with that of porcine YM strain to 93.71% with equine HI23 strain of rotavirus. A group A-specific NSP4 monoclonal antibody recognized the glycosylated and unglycosylated forms of the protein from virus-infected lysates, suggesting a well-conserved group-specificity of the lamb NSP4. Phylogenetic analysis of the lamb rotavirus gene, with 60 other NSP4 gene sequences of human and animal rotavirus strains, demonstrated that the lamb rotavirus strain belongs to genotype A. Comparative analysis also revealed that although it is a vaccine strain, the NSP4 cytotoxic domain of lamb strain demonstrated an overall amino acid conservation similar to that of other strains, whose NSP4 alone causes diarrhoea in animal models. These results taken together with our previous observations clearly reaffirm the idea that the attenuation phenotype of rotaviruses does not involve NSP4 cytotoxic domain, perhaps due to the suppression of NSP4 cytotoxic activity by other rotaviral proteins.
KW - amino acid sequences
KW - attenuation
KW - children
KW - cytotoxicity
KW - diarrhoea
KW - DNA cloning
KW - DNA sequencing
KW - genes
KW - genetic variation
KW - genotypes
KW - human diseases
KW - monoclonal antibodies
KW - nucleotide sequences
KW - phenotypes
KW - phylogeny
KW - vaccines
KW - China
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - diarrhea
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - People's Republic of China
KW - protein sequences
KW - scouring
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033094133&site=ehost-live&scope=site
UR - email: atreya@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of clinical nutrition education and educator discipline on glycemic control outcomes in the Indian Health Service.
AU - Wilson, C.
AU - Brown, T.
AU - Acton, K.
AU - Gilliland, S.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2003///
VL - 26
IS - 9
SP - 2500
EP - 2504
CY - Alexandria; USA
PB - American Diabetes Association, Inc.
SN - 0149-5992
AD - Wilson, C.: Indian Health Service, Phoenix Indian Medical Center, 4212 N. 16th St., Phoenix, AZ 85016, USA.
N1 - Accession Number: 20033189146. Publication Type: Journal Article. Language: English. Registry Number: 9062-63-9. Subject Subsets: Human Nutrition
N2 - OBJECTIVE - We used the Indian Health Service (IHS) Diabetes Care and Outcomes Audit to assess the effectiveness of clinical nutrition education in reducing HbA1c levels and to test the relative effectiveness of clinical nutrition education when it was delivered by a registered dietitian (RD) compared with an educator from another discipline (non-RD). RESEARCH DESIGN AND METHODS - We examined clinical care data collected by the IHS Diabetes Care and Outcomes Audit of 7,490 medical records during 2001. Glycemic control was assessed by using the difference between the two most recent HbA1c levels during 2001. Age, BMI, duration of diabetes, type of treatment, proteinuria, and facility were included as covariates. Clinical nutrition education was defined as documentation in the record of any diet instruction and educator discipline classified as RD or non-RD. ANCOVA methods were used to assess the effects of diet education and educator discipline on differences between the two HbA1c measurements and to adjust for differences in the distribution of covariates among the education groups. RESULTS - After adjustment for age, sex, type of treatment, duration of diabetes, BMI, initial HbA1c level, and clinical facility, clinical nutrition education and educator discipline were each associated with changes in HbA1c levels (P<0.001). Those receiving clinical nutrition education from an RD or from an RD as well as a non-RD had the largest improvements in HbA1c levels (-0.26 and -0.32, respectively) compared with those receiving either only non-RD or no clinical nutrition education (-0.19 and -0.10, respectively). CONCLUSIONS - Clinical nutrition education in the IHS is associated with favorable trends in glycemic control. To be effective, clinical nutrition education should be delivered by an RD or a team that includes an RD.
KW - blood sugar
KW - clinical nutrition
KW - diabetes mellitus
KW - discipline
KW - haemoglobin A1
KW - human diseases
KW - nutrition education
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - blood glucose
KW - glucose in blood
KW - hemoglobin A1
KW - United States of America
KW - Education and Training (CC100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033189146&site=ehost-live&scope=site
UR - http://care.diabetesjournals.org/cgi/content/abstract/26/9/2500
UR - email: charlton.wilson@pimc.ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human cargo: health conditions of Chinese migrants interdicted offshore by U.S. authorities.
AU - Schneider, D. L.
AU - Steiner, R.
AU - Romaine, J.
JO - Journal of Community Health
JF - Journal of Community Health
Y1 - 2003///
VL - 28
IS - 1
SP - 19
EP - 39
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0094-5145
AD - Schneider, D. L.: Health Resources and Services Administration, Bureau of Primary Health Care, Division of Immigration Health Services, 1220 L Street, NW, Suite 10, Washington, DC 20005, USA.
N1 - Accession Number: 20033023088. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Mycology; Rural Development
N2 - During the eight month period between April and December 1999, the United States Coast Guard intercepted seven boats carrying migrants from the People's Republic of China destined for the United States. These migrants were processed by the United States Immigration and Naturalization Service in three locations: Tinian Island, Midway Island, and Guatemala. Emergency Medical Response Teams from the United States Public Health Service, Division of Immigration Health Services, were deployed to conduct initial health screenings of the 913 migrants on board these ships and provide on-going health care until the individuals were repatriated or relocated. The distributions of demographic characteristics of the population and the health conditions observed are presented. Differences in health conditions observed by temporary detention location, sex, and age group were assessed. The majority of migrants were males younger than age 30. Few serious illnesses were observed. The most prevalent conditions included skin rashes, fungal rashes, upper respiratory infections, abdominal discomfort, scabies, abrasions, skin lesions, headache, pain and/or injuries, dental problems, and ear problems. For many health conditions, statistically significant differences were observed by location. For nearly all conditions for which differences were observed by sex, these differences were accounted for by a greater proportion of females presenting with the condition.
KW - bacterial diseases
KW - boats
KW - ear diseases
KW - human diseases
KW - migrants
KW - migration
KW - mycoses
KW - respiratory diseases
KW - screening
KW - skin diseases
KW - tooth diseases
KW - viral diseases
KW - China
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - dermatoses
KW - lung diseases
KW - People's Republic of China
KW - screening tests
KW - United States of America
KW - viral infections
KW - Demography (UU200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033023088&site=ehost-live&scope=site
UR - email: Diana.Schneider@usdoj.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food safety and global security.
AU - Crawford, L.
JO - Journal of Veterinary Medical Education
JF - Journal of Veterinary Medical Education
Y1 - 2003///
VL - 30
IS - 2
SP - 110
EP - 111
CY - Toronto; Canada
PB - University of Toronto Press Inc.
SN - 0748-321X
AD - Crawford, L.: Food and Drug Administration (FDA), 5600 Fishers Lane, Rockville, MD 20857-0001, USA.
N1 - Accession Number: 20033145142. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Veterinary Science
KW - food safety
KW - foodborne diseases
KW - legislation
KW - outbreaks
KW - terrorism
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033145142&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of real-time RT-PCR for evaluation of JEV clearance during purification of HPV type 16 L1 virus-like particles.
AU - Jeong HyeSung
AU - Shin JinHo
AU - Park YoungNam
AU - Choi JungYun
AU - Kim YoungLim
AU - Kim ByoungGuk
AU - Ryu SeungRel
AU - Baek SunYoung
AU - Lee SeokHo
AU - Park SueNie
JO - Biologicals
JF - Biologicals
Y1 - 2003///
VL - 31
IS - 3
SP - 223
EP - 229
CY - London; UK
PB - Academic Press
SN - 1045-1056
AD - Jeong HyeSung: Division of Viral Products, Korea Food and Drug Administration, 5 Nokbun, Eunpyeong, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20033156186. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Agricultural Biotechnology; Tropical Diseases; Medical & Veterinary Entomology
N2 - Insect cell culture has greatly increased in part due to the widespread use of insect virus-based vectors for efficient expression of foreign proteins. Insect cells such as Sf9 cells are susceptible to arboviruses which may pose a safety concern by adventitious introduction during the production process. The objective of this study was to establish techniques for viral clearance validation of insect cell-derived biotechnological products using Japanese encephalitis virus (JEV) as a model, since JEV is a member of arthropod-borne flaviviruses that are known to be infectious in insect cells. Here we report the development of a quantitative assay for JEV RNA using real-time reverse transcription-polymerase chain reaction (RT-PCR). The assay was performed using LightCycler and RNA amplification kit SYBR Green I. The JEV specific primer was selected from the 3′ untranslated region, and the expected band size was 323 base pairs (bp). The sensitivity of the assay was calculated to be approximately 15 TCID50 per reaction. Highly reproducible standard curves were obtained from experiments performed on three different days. JEV clearance was determined during the purification process of rHPV-16 L1 VLPs by CsCl equilibrium density centrifugation. The comparative results obtained by real-time RT-PCR assay for JEV and infectivity titrations suggested that the real-time RT-PCR assay could have an additive effect on the interpretation and evaluation of virus clearance, especially during the virus removal process.
KW - assays
KW - biotechnology
KW - cell cultures
KW - methodology
KW - polymerase chain reaction
KW - vaccine development
KW - Japanese encephalitis virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - methods
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033156186&site=ehost-live&scope=site
UR - email: suenie@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simian immunodeficiency viruses from multiple lineages infect human macrophages: implications for cross-species transmission.
AU - Grimm, T. A.
AU - Beer, B. E.
AU - Hirsch, V. M.
AU - Clouse, K. A.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2003///
VL - 32
IS - 4
SP - 362
EP - 369
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Grimm, T. A.: Laboratory of Cell Biology, Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluations and Review, U.S. Food and Drug Administration, National Institutes of Health, HFM-558, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20033068669. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - Zoonotic transfer of simian immunodeficiency virus (SIV) from chimpanzees and sooty mangabeys to humans has been documented on at least seven occasions. Several recently identified SIV isolates have also been shown to replicate efficiently in human peripheral blood mononuclear cells (PBMCs) in vitro, indicative of the potential for additional cross-species transmission via T cell infection. Although SIV predominantly uses the macrophage-tropic HIV chemokine coreceptor CCR5, little is known about the ability of SIV to infect human macrophages. In this study, 16 SIV isolates belonging to five different primate lentivirus lineages were tested for their ability to infect human monocyte-derived macrophages (MDMs). Twelve of the viruses were capable of infecting MDMs, and 11 of these were also able to replicate in human PBMCs. The replication capacity of the isolates differed within and between the various families and was dependent on particular donor macrophages. Our results suggest that most simian lentiviruses characterized to date not only have the ability to infect primary human T lymphocytes but also replicate efficiently in macrophages, thereby increasing the potential for cross-species transmission into the human population. Comparative studies using these isolates may facilitate the identification of characteristics that contribute to virus infectivity and pathogenicity.
KW - human diseases
KW - macrophages
KW - pathogenicity
KW - zoonoses
KW - Cercocebus
KW - chimpanzees
KW - man
KW - simian immunodeficiency virus
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pan
KW - Pongidae
KW - Homo
KW - Hominidae
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033068669&site=ehost-live&scope=site
UR - email: clouse@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acculturation and the health and well-being of U.S. immigrant adolescents.
AU - Yu, S. M.
AU - Huang, Z. J.
AU - Schwalberg, R. H.
AU - Overpeck, M.
AU - Kogan, M. D.
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
Y1 - 2003///
VL - 33
IS - 6
SP - 479
EP - 488
CY - New York; USA
PB - Elsevier Science Inc.
SN - 1054-139X
AD - Yu, S. M.: Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20043089648. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Purpose: To examine the association of acculturation, as measured by language spoken at home, with the health, psychosocial, school, and parental risk factors of adolescents of various racial/ethnic groups. Methods: Using the U.S. component of the 1997-98 World Health Organization Study of Health Behavior in School Children, bivariate and multiple logistic regression analyses were conducted of records for adolescents in four racial/ethnic groups to explore the relationship between the language spoken at home and outcome variables regarding health status and risks, psychosocial and school risk factors, and parental factors. Data were analyzed using Software for the Statistical Analysis of Correlated Data (SUDAAN). Results: Adolescents of all racial and ethnic groups who primarily speak a language other than English at home are at elevated risk for psychosocial risk factors such as alienation from classmates and being bullied, and parental risk factors such as feeling that their parents are not able or willing to help them. Those who speak a combination of languages are also at risk for being bullied and for high parental expectations. Language spoken at home is generally not associated with health and safety measures for adolescents across racial/ethnic groups. Conclusions: Adolescents whose primary language at home is not English experience higher psychosocial, school, and parental risks than non-Hispanic white English-speakers. New immigrant youths of all races and ethnic groups would potentially benefit from preventive and risk-reduction services.
KW - acculturation
KW - adolescents
KW - children
KW - ethnic groups
KW - health
KW - immigrants
KW - languages
KW - parents
KW - psychosocial aspects
KW - racial discrimination
KW - risk factors
KW - school children
KW - schools
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - school buildings
KW - school kids
KW - schoolchildren
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043089648&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T80-4B22V18-9&_user=10&_handle=B-WA-A-A-AZ-MsSAYVW-UUW-AUYEEZBUYZ-AUYDCVBYYZ-VDUAAEAEZ-AZ-U&_fmt=summary&_coverDate=12%2F31%2F2003&_rdoc=8&_orig=browse&_srch=%23toc%235072%232003%23999669993%23471126!&_cdi=5072&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bfd5369f97dc3c180ee09c262ad90198
UR - email: syu@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent trends in HIV-related inpatient admissions 1996-2000: a 7-state study.
AU - Fleishman, J. A.
AU - Hellinger, F. H.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2003///
VL - 34
IS - 1
SP - 102
EP - 110
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Fleishman, J. A.: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20033162009. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - Background and Objectives: HIV-related inpatient utilization declined immediately after the diffusion of highly active antiretroviral therapy (HAART), but some studies suggest that admission rates may have recently begun to increase. Using comprehensive hospital discharge data from 7 states, this study examines trends in HIV-related inpatient admissions and length of stay (LOS) from 1996 through 2000. Methods: We identified HIV-related admissions by ICD-9-CM diagnosis codes in the range from 042 to 044. Analyses assessed differential patterns of change over time, depending on state, gender, race/ethnicity, and insurance. Results: HIV-related inpatient admissions generally declined each year, but the rate of decline diminished recently. A similar pattern held for trends in inpatient LOS. Admissions for white male patients and for patients with private insurance showed the greatest decreases and the least leveling of the trend. The proportion of HIV admissions to total admissions was highest for black men and lowest for white women. In contrast to the period from 1993 through 1996, the proportion of HIV admissions covered by Medicare was greater than the rate of privately insured admissions. Conclusions: Although there is no substantial evidence for widespread increases in admissions during this period, results suggest that the trend in HIV-related hospital admissions is level in recent years. Racial/ethnic disparities in inpatient utilization persist. Further analysis of the impact of treatment failure or HAART-related complications on HIV admissions is warranted.
KW - acquired immune deficiency syndrome
KW - blacks
KW - epidemiology
KW - ethnic groups
KW - HIV infections
KW - hospitals
KW - human diseases
KW - human immunodeficiency viruses
KW - Medicare
KW - men
KW - whites
KW - women
KW - California
KW - Colorado
KW - Kansas
KW - Maryland
KW - New Jersey
KW - New York
KW - South Carolina
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Mountain States of USA
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Southeastern States of USA
KW - AIDS
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - inpatient admissions
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033162009&site=ehost-live&scope=site
UR - email: jfleishm@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on crude drugs from Atractylodes species.
AU - Cho Hyoungkwon
AU - Kim Hohyun
AU - Chon Inju
AU - Kang Inho
AU - Ham Inhye
AU - Ze KeamRyon
AU - Whang WanKyunn
JO - Korean Journal of Pharmacognosy
JF - Korean Journal of Pharmacognosy
Y1 - 2003///
VL - 34
IS - 2
SP - 123
EP - 127
CY - Kwangju; Korea Republic
PB - Korean Society of Pharmacognosy
SN - 0253-3073
AD - Cho Hyoungkwon: Korean Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20033122256. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 10 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - Results are presented of an experiment that evaluated the efficacy of GC-MS and HPLC in the differentiation among the medicinal plants that constitute the herbal drugs Atractylodis Rhizoma (Atractylodes lancea and A. chinensis in China, Japanese and Korea, and A. japonica in Korea) and Atractylodis Rhizoma Alba (A. macrocephala in China, and A. japonica and A. ovata in Korea and Japan).
KW - chemical composition
KW - GC-MS
KW - herbal drugs
KW - HPLC
KW - medicinal plants
KW - methodology
KW - plant composition
KW - techniques
KW - traditional medicines
KW - Atractylodes japonica
KW - Atractylodes lancea
KW - Atractylodes
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Atractylodes chinensis
KW - Atractylodes macrocephala
KW - Atractylodes ovata
KW - chemical constituents of plants
KW - drug plants
KW - gas chromatography-mass spectrometry
KW - herbal medicines
KW - high performance liquid chromatography
KW - medicinal herbs
KW - methods
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033122256&site=ehost-live&scope=site
UR - email: whang-wk@cau.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extensive retinal neovascularization as a late finding in human immunodeficiency virus-infected patients with immune recovery uveitis.
AU - Wright, M. E.
AU - Suzman, D. L.
AU - Csaky, K. G.
AU - Masur, H.
AU - Polis, M. A.
AU - Robinson, M. R.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003///
VL - 36
IS - 8
SP - 1063
EP - 1066
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Wright, M. E.: National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, 10 Center Dr., Bethesda, MD 20892, USA.
N1 - Accession Number: 20033096578. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - Sixteen human immunodeficiency virus (HIV)-infected patients with inactive cytomegalovirus (CMV) retinitis who had discontinued systemic anti-CMV therapy while receiving highly active antiretroviral therapy (HAART) were prospectively observed. Fifteen patients developed immune recovery uveitis (IRU); 3 of the patients developed extensive retinal neovascularization, 1 of whom required vitrectomy for recurrent vitreous hemorrhages. These late complications indicate a need for continued ophthalmologic follow-up of HIV-infected patients who have a history of CMV retinitis, even for individuals who have not required anti-CMV therapy for >4 years.
KW - antiviral agents
KW - cytomegalovirus retinitis
KW - eye diseases
KW - eyes
KW - haemorrhage
KW - highly active antiretroviral therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - multiple drug therapy
KW - retina
KW - surgery
KW - surgical operations
KW - uveitis
KW - viral diseases
KW - Human herpesvirus 5
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Cytomegalovirus
KW - Betaherpesvirinae
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bleeding
KW - combination drug therapy
KW - HAART
KW - hemorrhage
KW - human cytomegalovirus
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - neovascularization
KW - viral infections
KW - vitrectomy
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033096578&site=ehost-live&scope=site
UR - email: mpolis@nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Integrating nutrition therapy into medical management of human immunodeficiency virus.
AU - Hayes, C. R.
A2 - Hayes, C. R.
T2 - Clinical Infectious Diseases
T3 - Special issue: Integrating nutrition therapy into medical management of human immunodeficiency virus.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003///
VL - 36
IS - Suppl. 2
SP - S51
EP - S109
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Hayes, C. R.: Health Resources and Services Administration, Department of Health and Human Services, HIV/AIDS Bureau, Office of Science and Epidemiology, Service Evaluation and Research Branch, 5600 Fishers Lane, Rockville, MD 20896, USA.
N1 - Accession Number: 20033077611. Publication Type: Journal issue. Note: Special issue: Integrating nutrition therapy into medical management of human immunodeficiency virus. Language: English. Subject Subsets: Human Nutrition; Public Health
N2 - This supplement contains a report on the current nutrition management and concerns of human immunodeficiency virus infection. Issues addressed in this supplement concern general nutritional management, evaluation and intervention for wasting, insulin resistance, fat redistribution, dyslipidaemia, lactic acidosis, food safety, and bone abnormalities.
KW - body fat
KW - bone diseases
KW - bones
KW - food safety
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - insulin resistance
KW - lactic acidosis
KW - redistribution
KW - therapeutic diets
KW - wasting disease
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - diet therapy
KW - dyslipidaemia
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - special diets
KW - therapeutic nutrition
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033077611&site=ehost-live&scope=site
UR - email: chayes@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food and water safety for persons infected with human immunodeficiency virus.
AU - Hayes, C.
AU - Elliot, E.
AU - Krales, E.
AU - Downer, G.
T3 - Special issue: Integrating nutrition therapy into medical management of human immunodeficiency virus.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003///
VL - 36
IS - Suppl. 2
SP - S106
EP - S109
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Hayes, C.: Health Resources and Services Administration, HIV/AIDS Bureau, Office of Science and Epidemiology, Service Evaluation and Research Branch, 5600 Fishers Lane, Rockville, MD 20896, USA.
N1 - Accession Number: 20033077613. Publication Type: Journal Article. Note: Special issue: Integrating nutrition therapy into medical management of human immunodeficiency virus. Language: English. Number of References: 31 ref. Registry Number: 7732-18-5. Subject Subsets: Human Nutrition; Protozoology; Public Health
N2 - Public health and food safety experts estimate that millions of episodes of illnesses annually can be traced to contaminated food and water. Food and water safety is extremely important to persons infected with the human immunodeficiency virus (HIV) or with acquired immunodeficiency syndrome (AIDS). A compromised immune system causes people with HIV or AIDS to be more susceptible to foodborne illness from eating foods that are unsafely handled and poorly prepared and from using water from unsafe sources. Food- and waterborne illnesses can cause diarrhea, nausea, and vomiting that can lead to weight loss. These illnesses can be minimized or prevented if proper precautions are taken.
KW - acquired immune deficiency syndrome
KW - clinical aspects
KW - diarrhoea
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunocompromised hosts
KW - nausea
KW - opportunistic infections
KW - vomiting
KW - water
KW - waterborne diseases
KW - bacteria
KW - man
KW - Protozoa
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - AIDS
KW - bacterium
KW - clinical picture
KW - diarrhea
KW - food contaminants
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - scouring
KW - Water Resources (PP200)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033077613&site=ehost-live&scope=site
UR - email: chayes@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extensive limb swelling after immunization: reports to the vaccine adverse event reporting system.
AU - Woo, E. J.
AU - Burwen, D. R.
AU - Gatumu, S. N. M.
AU - Ball, R.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003///
VL - 37
IS - 3
SP - 351
EP - 358
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Woo, E. J.: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20033165132. Publication Type: Journal Article. Corporate Author: USA, Vaccine Adverse Event Reporting System (VAERS) Working Group Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - Extensive limb swelling (ELS) has been reported after vaccination with a limited number of vaccine types. We sought to describe vaccine types involved in and the clinical characteristics of ELS cases reported to the Vaccine Adverse Event Reporting System (VAERS). A case of ELS was defined as any report of oedema extending at least to the elbow or knee of a vaccinated extremity. Four hundred ninety-seven cases were identified, with some describing swelling from the shoulder to the hand or the hip to the foot. Patient age ranged from 0.1 to 91 years. The proportion of reports of ELS associated with a given vaccine, among all VAERS reports received for that vaccine, varied substantially among vaccines. Most reactions began within 1 day after vaccination and involved other signs of inflammation. Postvaccination ELS can involve both the proximal and distal segments of the extremity, affects all age groups, and occurs after vaccination with a broad range of vaccines.
KW - adverse effects
KW - human diseases
KW - immunization
KW - inflammation
KW - limbs
KW - oedema
KW - vaccination
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - edema
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033165132&site=ehost-live&scope=site
UR - email: wooj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rabies among infrequently reported mammalian carnivores in the United States, 1960-2000.
AU - Krebs, J. W.
AU - Williams, S. M.
AU - Smith, J. S.
AU - Rupprecht, C. E.
AU - Childs, J. E.
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
Y1 - 2003///
VL - 39
IS - 2
SP - 253
EP - 261
CY - Lawrence; USA
PB - Wildlife Disease Association
SN - 0090-3558
AD - Krebs, J. W.: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road MS/G13, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033120988. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Most cases of rabies reported annually in the United States occur among three groups of carnivores - raccoons (Procyon lotor), skunks (Mephitis, Spilogale, and Putorius), foxes (Vulpes, Urocyon, and Alopex) - and among bats (numerous species). However, between 1960 and 2000, a total of 2 851 cases of rabies in 17 other carnivore taxa were reported to the Centers for Disease Control and Prevention, Atlanta, Georgia (USA), from 49 states, the District of Columbia, and Puerto Rico. Three species of these other carnivores (mongooses [Herpestes javanicus], coyotes [Canis latrans], and bobcats [Lynx rufus]) accounted for 92% (2 624/2 851) of the cases reported among other carnivorous mammals (OCMs). Most OCMs demonstrated temporal or spatial variation in numbers of reported cases. Tests of specimens from OCMs infected in the United States identified variants of the rabies virus that corresponded with variants associated with the major terrestrial reservoirs within their respective regions of origin. Variants of the rabies virus in samples from mongooses in Puerto Rico could not be distinguished from those in samples from dogs in Puerto Rico by virus typing methods.
KW - epidemiology
KW - rabies
KW - USA
KW - Mephitis
KW - Mustela
KW - Procyon lotor
KW - Spilogale
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Procyon
KW - Procyonidae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033120988&site=ehost-live&scope=site
UR - email: jok2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of North American eastern and western equine encephalitis viruses by nucleic acid amplification assays.
AU - Lambert, A. J.
AU - Martin, D. A.
AU - Lanciotti, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 1
SP - 379
EP - 385
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Lambert, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampart Rd., Fort Collins, CO 80521, USA.
N1 - Accession Number: 20033020783. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
N2 - We have developed nucleic acid sequence-based amplification (NASBA), standard reverse transcription PCR (RT-PCR), and TaqMan nucleic acid amplification assays for the rapid detection of North American eastern equine encephalitis (EEE) and western equine encephalitis (WEE) viral RNAs from samples collected in the field and clinical samples. The sensitivities of these assays have been compared to that of virus isolation. While all three types of nucleic acid amplification assays provide rapid detection of viral RNAs comparable to the isolation of viruses in Vero cells, the TaqMan assays for North American EEE and WEE viral RNAs are the most sensitive. We have shown these assays to be specific for North American EEE and WEE viral RNAs by testing geographically and temporally distinct strains of EEE and WEE viruses along with a battery of related and unrelated arthropodborne viruses. In addition, all three types of nucleic acid amplification assays have been used to detect North American EEE and WEE viral RNAs from mosquito and vertebrate tissue samples. The sensitivity, specificity, and rapidity of nucleic acid amplification demonstrate the usefulness of NASBA, standard RT-PCR, and TaqMan assays, in both research and diagnostic settings, to detect North American EEE and WEE viral RNAs.
KW - assays
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - encephalitis
KW - polymerase chain reaction
KW - RNA
KW - eastern equine encephalitis virus
KW - western equine encephalitis virus
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - encephalomyelitis
KW - PCR
KW - ribonucleic acid
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033020783&site=ehost-live&scope=site
UR - email: ahk7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of three commercial assays for detection of Giardia and Cryptosporidium organisms in fecal specimens.
AU - Johnston, S. P.
AU - Ballard, M. M.
AU - Beach, M. J.
AU - Causer, L.
AU - Wilkins, P. P.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 2
SP - 623
EP - 626
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Johnston, S. P.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, 4770 Buford Highway, NE, MS F-36, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20033045664. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Mycology; Protozoology; Public Health
N2 - There is an increasing demand for diagnostic testing for Giardia intestinalis (G. lamblia) and Cryptosporidium parvum, with a priority being placed on obtaining diagnostic results in an efficient and timely manner. Several commercial companies have developed rapid diagnostic tests that are simple to perform and can be completed in less time than traditional methods for detecting Giardia and Cryptosporidium. We compared one of these rapid tests, the ImmunoCard STAT! (Meridian Bioscience, Inc.) lateral-flow immunoassay, with the MERIFLUOR direct fluorescent-antibody (DFA) test, the ProSpecT EZ microplate assay for Giardia and the ProSpecT microplate assay for Cryptosporidium, and modified Kinyoun's acid-fast stained smears for the detection of Cryptosporidium using 246 specimens. The MERIFLUOR DFA (Meridian Bioscience, Inc.) test detected the largest number of cases (32 Giardia and 37 Cryptosporidium) infections and was used to calculate the sensitivity and specificity of the other tests. For Giardia, the sensitivities of the ImmunoCard STAT! and the ProSpecT Giardia EZ microplate assay (Alexon-Trend, Inc.) were 81 and 91%, respectively. For detection of Cryptosporidium, the sensitivities of the ImmunoCard STAT!, the ProSpecT Cryptosporidium microplate assay (Alexon-Trend, Inc.), and modified Kinyoun's acid-fast stained smears were 68, 70, and 78%, respectively. Test specificities were equal to or greater than 99%. Specimens with very small numbers of organisms were not detected by the ImmunoCard STAT!, the ProSpecT microplate assay or modified Kinyoun's acid-fast stained smears.
KW - assays
KW - diagnosis
KW - diagnostic techniques
KW - faeces
KW - human diseases
KW - Georgia
KW - USA
KW - Cryptosporidium parvum
KW - Giardia duodenalis
KW - man
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Sarcomastigophora
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - feces
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033045664&site=ehost-live&scope=site
UR - email: sjohnston@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of anti-West Nile virus immunoglobulin M in chicken serum by an enzyme-linked immunosorbent assay.
AU - Johnson, A. J.
AU - Langevin, S.
AU - Wolff, K. L.
AU - Komar, N.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 5
SP - 2002
EP - 2007
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Johnson, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20033096089. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Veterinary Science; Poultry
N2 - The emergence of West Nile (WN) virus in New York and the surrounding area in 1999 prompted an increase in surveillance measures throughout the United States, including the screening of sentinel chicken flocks for antibodies. An enzyme-linked immunosorbent assay (ELISA) for the detection of chicken immunoglobulin M (IgM) to WN virus was developed, standardized, and characterized as a rapid and sensitive means to detect WN viral antibodies in sentinel flocks. Serum specimens from experimentally infected chickens were analyzed by using this assay, and IgM was detected as early as 3 to 7 days postinfection. Persistence of IgM varied from at least 19 to more than 61 days postinfection, which indicates the need to bleed sentinel flocks at least every 2 weeks for optimal results if this method is to be used as a screening tool. The ELISA was compared to hemagglutination-inhibition and plaque reduction neutralization tests and was found to be the method of choice when early detection of WN antibody is required. House sparrows and rock doves are potential free-ranging sentinel species for WN virus, and the chicken WN IgM-capture ELISA was capable of detecting anti-WN IgM in house sparrow serum samples from laboratory-infected birds but not from rock dove serum samples. The chicken WN IgM-capture ELISA detected anti-WN antibodies in serum samples from naturally infected chickens. It also detected IgM in serum samples from two species of geese and from experimentally infected ring-necked pheasants, American crows, common grackles, and redwinged blackbirds. However, the test was determined to be less appropriate than an IgG (IgY)-based assay for use with free-ranging birds. The positive-to-negative ratios in the ELISA were similar regardless of the strain of WN viral antigen used, and only minimal cross-reactivity was observed between the WN and St. Louis encephalitis (SLE) IgM-capture ELISAs. A blind-coded serum panel was tested, and the chicken WN IgM-capture ELISA produced consistent results, with the exception of one borderline result. A preliminary test was done to assess the feasibility of a combined SLE and WN IgM-capture ELISA, and results were promising.
KW - blood serum
KW - ELISA
KW - IgM
KW - immunodiagnosis
KW - poultry
KW - Corvus
KW - fowls
KW - geese
KW - Phasianus
KW - pheasants
KW - Turdidae
KW - Turdus merula
KW - West Nile virus
KW - Corvidae
KW - Passeriformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - Anser
KW - Anatidae
KW - Anseriformes
KW - Turdus
KW - Turdidae
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - chickens
KW - domesticated birds
KW - enzyme linked immunosorbent assay
KW - serological diagnosis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Diagnosis of Animal Diseases (LL886) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033096089&site=ehost-live&scope=site
UR - email: ajj1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Olejnik, N.
AU - Wiesenfeld, P. W.
AU - Babu, U. S.
AU - Bryant, M.
AU - Flynn, T. J.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2003///
VL - 41
IS - 6
SP - 819
EP - 834
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20033096394. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition; Animal Nutrition; Animal Breeding
N2 - Flaxseed, a rich source of reportedly beneficial n-3 fatty acid and phytoestrogens, has not been thoroughly tested for reproductive effects. High levels of flaxseed (FS, 20 or 40%) or defatted flaxseed meal (FLM, 13 or 26%) added to AIN-93 diet were evaluated in a two-phase study: dosed during gestation only or during gestation and maturation in a lifetime study. At cesarean section on gestation day 20, neither FS nor FLM affected fertility, body weight gain, litter size, or fetal development. FLM, but not FS, decreased gestation length. The offspring of dams allowed to litter were observed to postnatal day (PND) 21 or 90. Neither FS nor FLM affected PND 21 survival indices of F1 pups. FS (20 and 40%), but not FLM, increased the anogenital index (AGI) of F1 females at PND 21. The AGI of F1 males was not affected by either FS or FLM. FLM (13 and 26%), but not FS, delayed puberty in F1 males. Age and weight at the onset of puberty in females were not affected by FS or FLM. FS and FLM caused dose-related increases in the number of F1 females with irregular estrous cycles. During PND 21-90, F1 females fed 20% FS, 13% FLM, or 26% FLM gained more weight than the controls. FS and FLM decreased thymus/body weight and thymus/brain weight ratios in weanling F1 males and females. FS and FLM decreased liver/body weight and liver/brain weight ratios in weanling F1 females, and 26% FLM decreased the same two ratios in F1 males. In conclusion, FS did not affect fetal development but did affect indices of postnatal development such as the estrous cycle.
KW - fatty acids
KW - fertility
KW - fetal development
KW - flax
KW - gestation period
KW - linseed
KW - litter size
KW - liveweight gain
KW - oestrous cycle
KW - plant oestrogens
KW - reproduction
KW - sexual maturity
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - breeding cycle
KW - estrous cycle
KW - gestation length
KW - liveweight gains
KW - phytoestrogens
KW - plant estrogens
KW - pregnancy duration
KW - reproductive cycle
KW - Animal Reproduction and Embryology (LL250) (New March 2000)
KW - Animal Nutrition (General) (LL500)
KW - Human Reproduction and Development (VV060)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
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UR - email: tfc@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Flaxseed increased α-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring.
AU - Wiesenfeld, P. W.
AU - Babu, U. S.
AU - Collins, T. F. X.
AU - Sprando, R.
AU - O'Donnell, M. W.
AU - Flynn, T. J.
AU - Black, T.
AU - Olejnik, N.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2003///
VL - 41
IS - 6
SP - 841
EP - 855
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Wiesenfeld, P. W.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20033096396. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 506-32-1, 25167-62-8, 10417-94-4, 60-33-3, 463-40-1. Subject Subsets: Human Nutrition
N2 - The effects of dietary flaxseed (FS), and defatted flaxseed meal (FLM) on serum and tissue fatty acid profiles were investigated. Pregnant Sprague-Dawley rats were fed AIN-93 based diets balanced in calories, fat, nitrogen, and fiber. Diets contained 0, 20%, 40% FS or 13% or 26% FLM by weight. The control, FS and FLM diets differed in linoleic acid to α-linolenic acid (ALA) fatty acid ratio. These diets were fed continuously during gestation, suckling period and 8 weeks post-weaning (F1). FS fatty acids were bioavailable and metabolized by pregnant and F1 rats. ALA and eicosapentaenoic acid increased; linoleic and arachidonic acid decreased; and docosahexaeonic acid was unchanged in serum, 'gastric milk' and liver of FS and FLM-fed pregnant and F1 rats. FS more than FLM, changed fatty acids profiles, but FLM and 40% FS significantly reduced serum cholesterol. Dietary 40% FS may have increased oxidative stress as evidenced by a reduction in liver vitamin E.
KW - arachidonic acid
KW - blood serum
KW - docosahexaenoic acid
KW - eicosapentaenoic acid
KW - fatty acids
KW - flax
KW - linoleic acid
KW - linolenic acid
KW - linseed
KW - tissues
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eicosatetraenoic acid
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
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UR - email: pwiesenf@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro and in vivo percutaneous absorption of catechol.
AU - Jung, C. T.
AU - Wickett, R. R.
AU - Desai, P. B.
AU - Bronaugh, R. L.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2003///
VL - 41
IS - 6
SP - 885
EP - 895
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Jung, C. T.: Office of Cosmetics and Colors, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20033096400. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 120-80-9. Subject Subsets: Human Nutrition
N2 - The Cosmetic Ingredient Review Expert Panel found insufficient data to conclude that catechol could be used safely in permanent hair dye products. Information was lacking on the extent of oxidation and skin absorption of remaining catechol. In vitro percutaneous absorption studies were conducted in human and rat skin using a consumer permanent hair dye spiked with 0.6% catechol. A 30-min application demonstrated 0.4% of the applied dose was absorbed through human skin and 0.2% through rat skin. The minimal absorption observed was due to the short exposure time and to partial oxidation of catechol by the dye developer. The fate of catechol remaining in rat skin after exposure in vitro and in vivo was investigated with additional absorption studies using catechol in ethanol. At 72 h, 24-h application of 4% catechol resulted in skin absorption of 81% of the applied dose in vitro and 53% in vivo. Skin levels measured at 24 h remained unchanged after 72 h. Therefore the skin reservoir did not contribute to the estimated systemic absorption. A deconvolution technique employed to predict skin absorption using plasma levels from intravenous and dermal administration overestimated in vivo skin absorption due to volatility of catechol in an ethanolic vehicle.
KW - absorption
KW - cutaneous application
KW - dyes
KW - hair
KW - in vitro
KW - pyrocatechol
KW - skin
KW - man
KW - rats
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - catechol
KW - dermis
KW - dyestuffs
KW - pyrocatechin
KW - transdermal application
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
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UR - email: cjung@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats.
AU - Babu, U. S.
AU - Wiesenfeld, P. W.
AU - Collins, T. F. X.
AU - Sprando, R.
AU - Flynn, T. J.
AU - Black, T.
AU - Olejnik, N.
AU - Raybourne, R. B.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2003///
VL - 41
IS - 6
SP - 905
EP - 915
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Babu, U. S.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20033096402. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 506-32-1, 11028-71-0, 102524-44-7, 85898-30-2, 463-40-1. Subject Subsets: Human Nutrition; Dairy Science
N2 - Flaxseed (FS) being rich in α-linolenic acid may alter the immune parameters. Therefore, we assessed the impact of FS and defatted flaxseed meal (FLM) on fatty acid composition, cell subsets, proliferation and IL-2 production by splenic lymphocytes. Pregnant female Sprague-Dawley rats were fed diets containing 0% FS and FLM, 20 or 40% FS, 13 or 26% FLM during gestation or gestation, lactation and 8 week post-weaning period. FS and FLM resulted in up to 8.3 fold and 4.6 fold increase in splenic ALA among pregnant rats, 4.5 fold and 1.2 fold increase in splenic ALA among F1 generation rats. Splenic linoleic acid (LA) and arachidonic acid (AA) were 18 and 40% lower in 40% FS fed pregnant rats, and AA was 15% lower in all the other groups. Among F1 rats, splenic LA and AA were 16 and 48% lower in 40% FS group, and AA was 18% lower in 20% FS and 26% FLM groups. Concanavalin A and phytohemagglutinin mediated proliferation of spleen cells were 60 and 52% lower in 40% FS fed pregnant and F1 generation rats, respectively. No significant changes were observed in the cell subsets or IL-2 production by splenic cells from different groups.
KW - animal models
KW - arachidonic acid
KW - concanavalin A
KW - fatty acids
KW - flax
KW - immune response
KW - interleukin 2
KW - lactation
KW - linolenic acid
KW - linseed
KW - mitogens
KW - phytohaemagglutinins
KW - pregnancy
KW - spleen
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eicosatetraenoic acid
KW - gestation
KW - immunity reactions
KW - immunological reactions
KW - phytohemagglutinins
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
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UR - email: usb@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microarray-based identification of thermophilic Campylobacter jejuni, C. coli, C. lari, and C. upsaliensis.
AU - Volokhov, D.
AU - Chizhikov, V.
AU - Chumakov, K.
AU - Rasooly, A.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 9
SP - 4071
EP - 4080
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Volokhov, D.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy., College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033170973. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - DNA microarrays are an excellent potential tool for clinical microbiology, since this technology allows relatively rapid identification and characterization of microbial and viral pathogens. In the present study, an oligonucleotide microarray was developed and used for the analysis of thermophilic Campylobacter spp., the primary food-borne pathogen in the United States. We analyzed four Campylobacter species: Campylobacter jejuni, C. coli, C. lari, and C. upsaliensis. Our assay relies on the PCR amplification of specific regions in five target genes (fur, glyA, cdtABC, ceuB-C, and fliY) as a first step, followed by microarray-based analysis of amplified DNAs. Alleles of two genes, fur and glyA, which are found in all tested thermophilic Campylobacter spp., were used for identification and discrimination among four bacterial species, the ceuB-C gene was used for discrimination between C. jejuni and C. coli, and the fliY and cdt genes were used as additional genetic markers specific either for C. upsaliensis and C. lari or for C. jejuni. The array was developed and validated by using 51 previously characterized Campylobacter isolates. All isolates were unambiguously identified on the basis of hybridization patterns with 72 individual species-specific oligoprobes. Microarray identification of C. jejuni and C. coli was confirmed by PCR amplification of other genes used for identification (hipO and ask). Our results demonstrate that oligonucleotide microarrays are suitable for rapid and accurate simultaneous differentiation among C. jejuni, C. coli, C. lari, and C. upsaliensis.
KW - analytical methods
KW - food contamination
KW - oligonucleotides
KW - polymerase chain reaction
KW - rapid methods
KW - Campylobacter coli
KW - Campylobacter jejuni
KW - Campylobacter lari
KW - Campylobacter upsaliensis
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
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UR - email: axr@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial susceptibility testing of aquatic bacteria: quality control disk diffusion ranges for Escherichia coli ATCC 25922 and Aeromonas salmonicida subsp. salmonicida ATCC 33658 at 22 and 28°C.
AU - Miller, R. A.
AU - Walker, R. D.
AU - Baya, A.
AU - Clemens, K.
AU - Coles, M.
AU - Hawke, J. P.
AU - Henricson, B. E.
AU - Hsu, H. M.
AU - Mathers, J. J.
AU - Oaks, J. L.
AU - Papapetropoulou, M.
AU - Reimschuessel, R.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 9
SP - 4318
EP - 4323
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Miller, R. A.: Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, HFV530, 8401 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20033171007. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 93106-60-6, 114-07-8, 73231-34-2, 76639-94-6, 1403-66-3, 1405-41-0, 6981-18-6, 14698-29-4, 79-57-2, 122-11-2, 723-46-6, 738-70-5. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - Quality control (QC) ranges for disk diffusion susceptibility testing of aquatic bacterial isolates were proposed as a result of a multilaboratory study conducted according to procedures established by the National Committee for Clinical Laboratory Standards (NCCLS). Ranges were proposed for Escherichia coli ATCC 25922 and Aeromonas salmonicida subsp. salmonicida ATCC 33658 at 22 and 28°C for nine different antimicrobial agents (ampicillin, enrofloxacin, erythromycin, florfenicol, gentamicin, oxolinic acid, oxytetracycline, ormetoprim-sulfadimethoxine, and trimethoprim-sulfamethoxazole). All tests were conducted on standard Mueller-Hinton agar. With ≥95% of all data points fitting within the proposed QC ranges, the results from this study comply with NCCLS guidelines and have been accepted by the NCCLS Subcommittee for Veterinary Antimicrobial Susceptibility Testing. These QC guidelines will permit greater accuracy in interpreting results and, for the first time, the ability to reliably compare susceptibility test data between aquatic animal disease diagnostic laboratories.
KW - ampicillin
KW - antibacterial agents
KW - aquatic animals
KW - bacterial diseases
KW - drug resistance
KW - enrofloxacin
KW - erythromycin
KW - florfenicol
KW - food contamination
KW - gentamicin
KW - ormetoprim
KW - oxolinic acid
KW - oxytetracycline
KW - quality controls
KW - sulfadimethoxine
KW - sulfamethoxazole
KW - trimethoprim
KW - Aeromonas salmonicida
KW - Escherichia coli
KW - Aeromonas
KW - Aeromonadaceae
KW - Aeromonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - food contaminants
KW - quality assurance
KW - sulphadimethoxine
KW - sulphamethoxazole
KW - terramycin
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Aquatic Biology and Ecology (MM300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
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UR - email: RMiller1@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of Salmonella enterica serotype Newport isolated from humans and food animals.
AU - Zhao, S.
AU - Qaiyumi, S.
AU - Friedman, S.
AU - Singh, R.
AU - Foley, S. L.
AU - White, D. G.
AU - McDermott, P. F.
AU - Donkar, T.
AU - Bolin, C.
AU - Munro, S.
AU - Baron, E. J.
AU - Walker, R. D.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2003///
VL - 41
IS - 12
SP - 5366
EP - 5371
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20043014460. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 58-71-9, 153-61-7, 33564-30-6, 35607-66-0, 80370-57-6, 73384-59-5, 74578-69-1, 56-75-7, 58001-44-8, 57-92-1, 723-46-6, 60-54-8, 64-75-5. Subject Subsets: Veterinary Science; Public Health; Poultry; Pig Science; Veterinary Science
N2 - Salmonella enterica serotype Newport isolates resistant to at least nine antimicrobials (including extended-spectrum cephalosporins), known as serotype Newport MDR-AmpC isolates, have been rapidly emerging as pathogens in both animals and humans throughout the United States. Resistance to extended-spectrum cephalosporins is associated with clinical failures, including death, in patients with systemic infections. In this study, 87 Salmonella serotype Newport strains were characterized by pulsed-field gel electrophoresis (PFGE) and antimicrobial susceptibility testing and examined for the presence of class 1 integrons and blaCMY genes. Thirty-five PFGE patterns were observed with XbaI, and three of these patterns were indistinguishable among isolates from humans and animals. Fifty-three (60%) Salmonella serotype Newport isolates were identified as serotype Newport MDR-AmpC, including 16 (53%) of 30 human isolates, 27 (93%) of 29 cattle isolates, 7 (70%) of 10 swine isolates, and 3 (30%) of 10 chicken isolates. However, 28 (32%) Salmonella serotype Newport isolates were susceptible to all 16 antimicrobials tested. The blaCMY gene was present in all serotype Newport MDR-AmpC isolates. Furthermore, the plasmid-mediated blaCMY gene was transferable via conjugation to an Escherichia coli strain. The transconjugant showed the MDR-AmpC resistance profile. Thirty-five (40%) of the isolates possessed class 1 integrons. Sequence analyses of the integrons showed that they contained aadA, which confers resistance to streptomycin, or aadA and dhfr, which confer resistance to trimethoprim-sulfamethoxazole. One integron from a swine isolate contained the sat-1 gene, which encodes resistance to streptothricin, an antimicrobial agent that has never been approved for use in the United States. In conclusion, Salmonella serotype Newport MDR-AmpC was commonly identified among Salmonella serotype Newport isolates recovered from humans and food animals. These findings support the possibility of transmission of this organism to humans through the food chain.
KW - amoxicillin
KW - ampicillin
KW - antibacterial agents
KW - bacterial diseases
KW - cefalotin
KW - cefoxitin
KW - ceftiofur
KW - ceftriaxone
KW - chloramphenicol
KW - clavulanic acid
KW - disease transmission
KW - drug susceptibility
KW - genome analysis
KW - human diseases
KW - multiple drug resistance
KW - poultry
KW - reservoir hosts
KW - resistance mechanisms
KW - streptomycin
KW - sulfamethoxazole
KW - tetracycline
KW - Maryland
KW - USA
KW - cattle
KW - fowls
KW - pigs
KW - Salmonella
KW - Salmonella enterica
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - amoxicillin-clavulanic acid
KW - amoxycillin
KW - animal reservoirs
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cephalothin
KW - chickens
KW - domesticated birds
KW - hogs
KW - sulphamethoxazole
KW - swine
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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UR - email: szhao@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterisation of Salmonella in a turkey production facility.
AU - Nayak, R.
AU - Kenney, P. B.
AU - Keswani, J.
AU - Ritz, C.
JO - British Poultry Science
JF - British Poultry Science
Y1 - 2003///
VL - 44
IS - 2
SP - 192
EP - 202
CY - Abingdon; UK
PB - Taylor & Francis Ltd
SN - 0007-1668
AD - Nayak, R.: US FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20033096004. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Veterinary Science; Poultry; Veterinary Science
N2 - A comprehensive ecological survey was conducted from April 1997 to June 1999 on 4 turkey flocks (F1 to F4), maintained in farms in Georgia, USA, to identify key pre-harvest sources/vectors of Salmonella colonization. Turkey caecal and crop content, litter, drinker, air, feed, feeder and environmental swab samples were collected. Conventional microbiological and serological procedures were used to isolate, identify, and confirm the presence or absence of Salmonella. Salmonella was isolated from 13% of litter, 11% of turkey caeca, 10% of drinker, 5% of environmental swab, 3% of feed and 1% of feeder samples. Salmonella heidelberg (65%), S. senftenberg (19%), S. muenster (10%), S. anatum (3%), and S. worthington (3%) were identified. Identifying environmental sources associated with Salmonella colonization and characterizing serotypes would assist in designing pre-harvest controls for this poultry-borne pathogen. Integrators and poultry producers may be able to design hazard analysis and critical control point (HACCP) protocols to reduce the incidence of Salmonella arriving at the processing plant.
KW - food contamination
KW - food processing
KW - food safety
KW - HACCP
KW - microbial contamination
KW - poultry
KW - turkey meat
KW - Salmonella anatum
KW - Salmonella muenster
KW - turkeys
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Meleagris
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - domesticated birds
KW - food contaminants
KW - hazard analysis critical control point
KW - hazard analysis critical control points
KW - Salmonella heidelberg
KW - Salmonella senftenberg
KW - Salmonella worthington
KW - Meat Producing Animals (LL120)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033096004&site=ehost-live&scope=site
UR - email: bkenney@mail.wvu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Non-fatal injuries in the West Virginia logging industry: using workers' compensation claims to assess risk from 1995 through 2001.
AU - Bell, J. L.
AU - Helmkamp, J. C.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2003///
VL - 44
IS - 5
SP - 502
EP - 509
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Bell, J. L.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road MS-1181, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20043008728. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: The logging industry has a high rate of both fatal and non-fatal injuries in comparison to other industries, and plays a vital role in WV's economy. Methods: Workers' compensation (WC) injury claims and employment data were summarized to examine patterns and rates of non-fatal logging injuries in WV from 1995 through 2001. Results: The average annual rate of injury claims was 16.0 per 100 workers per year with rates remaining relatively steady over the 7-year study period. The highest rates of injury were a result of being struck by an object, typically trees, snags, or logs. Conclusions: WV loggers most often file injury claims as a result of being struck by trees and tree parts, snags, and logs. Assessment of risk is a critical component in helping regulators, researchers, and the logging industry develop viable prevention strategies to reduce the incidence and severity of logging-related injuries.
KW - epidemiology
KW - logging
KW - risk
KW - trauma
KW - workers
KW - USA
KW - West Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - timber extraction
KW - timber harvesting
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043008728&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/106558904/ABSTRACT
UR - email: jbell@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
AU - Crowell, A. L.
AU - Sanders-Lewis, K. A.
AU - Secor, W. E.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2003///
VL - 47
IS - 4
SP - 1407
EP - 1409
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Crowell, A. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20033060605. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 443-48-1, 19387-91-8. Subject Subsets: Protozoology; Aromatic & Medicinal Plants
N2 - The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.
KW - antiprotozoal agents
KW - antiprotozoal properties
KW - drug resistance
KW - in vitro
KW - metronidazole
KW - tinidazole
KW - Trichomonas vaginalis
KW - Trichomonas
KW - Trichomonadidae
KW - Trichomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - anti-protozoal properties
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033060605&site=ehost-live&scope=site
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening adenoviruses in stool samples: evaluation of a genus-specific monoclonal antibody based enzyme immunoassay.
AU - Bányai, K.
AU - Máté, Z.
AU - Ádám, É.
AU - Új, M.
AU - Nász, I.
AU - Szucs, G.
JO - Acta Microbiologica et Immunologica Hungarica
JF - Acta Microbiologica et Immunologica Hungarica
Y1 - 2003///
VL - 50
IS - 1
SP - 23
EP - 32
CY - Budapest; Hungary
PB - Akadémiai Kiadó
SN - 1217-8950
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, P.O. Box 47, H-7601 Pécs, Hungary.
N1 - Accession Number: 20033090248. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - A genus-specific monoclonal antibody based enzyme immunoassay was developed for screening faecal specimens for adenovirus antigens. The assay was found to be specific and sensitive. 180 faecal samples obtained in Baranya County, Pécs, Hungary were tested using the assay. 13 (7.2%) came out positive for adenovirus antigens.
KW - diagnosis
KW - diagnostic techniques
KW - enzyme immunoassay
KW - faeces
KW - human diseases
KW - screening
KW - viral diseases
KW - Hungary
KW - Adenoviridae
KW - man
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - feces
KW - screening tests
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033090248&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of dietary supplements for arsenic, cadmium, mercury, and lead using inductively coupled plasma mass spectrometry.
AU - Dolan, S. P.
AU - Nortrup, D. A.
AU - Bolger, P. M.
AU - Capar, S. G.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2003///
VL - 51
IS - 5
SP - 1307
EP - 1312
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Dolan, S. P.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053072370. Publication Type: Journal Article. Language: English. Registry Number: 7440-38-2, 7440-43-9, 7439-92-1, 7439-97-6. Subject Subsets: Human Nutrition
N2 - The arsenic, cadmium, mercury, and lead contents of 95 dietary supplement products were determined using microwave digestion and high-resolution inductively coupled plasma mass spectrometry. Precision and accuracy were demonstrated by element recovery from 17 dietary supplements and replicates of 8 reference materials. The concentration ranges were as follows: arsenic, <5-3770 µg/kg; cadmium, <10-368 µg/kg; mercury, <80-16800 µg/kg; and lead, <20-48600 µg/kg. An assessment of estimated exposures/intakes of the four elements is presented.
KW - arsenic
KW - cadmium
KW - food intake
KW - food supplements
KW - lead
KW - mass spectrometry
KW - mercury
KW - quantitative analysis
KW - Food Composition and Quality (QQ500)
KW - Diet Studies (VV110)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053072370&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2003/51/i05/abs/jf026055x.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatography analysis of erythromycin A in salmon tissue by electrochemical detection with confirmation by electrospray ionization mass spectrometry.
AU - Billedeau, S. M.
AU - Heinze, T. M.
AU - Siitonen, P. H.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2003///
VL - 51
IS - 6
SP - 1534
EP - 1538
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Billedeau, S. M.: Division of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053072293. Publication Type: Journal Article. Language: English. Registry Number: 114-07-8. Subject Subsets: Human Nutrition
N2 - A rapid and sensitive method is described for the quantitation of erythromycin A (EA) in edible salmon tissue by liquid chromatography (LC) analysis using either electrochemical detection (ED) or electrospray ionization mass spectrometric (ESI/MS) detection. The salmon tissue is extracted with 10 mM ammonium formate. The extract is then purified by solid phase extraction using a hydrophilic-lipophilic balanced (HLB) polymeric-based C18 packing, followed by partitioning of EA into methylene chloride at alkaline pH, evaporation, and final dilution. The mean recoveries of EA at 50, 100, 200, and 400 ppb levels in fortified salmon tissue were 63.8±6.0 and 75.5±5.4% by LC-ED and LC-ESI/MS, respectively. There was no evidence of formation of the anhydro-EA (m/z 716) decomposition product of EA (m/z 734) that was reported to occur by other published methods.
KW - decomposition
KW - erythromycin
KW - liquid chromatography
KW - mass spectrometry
KW - quantitative analysis
KW - salmon
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - ionization mass spectrometry
KW - Aquatic Produce (QQ060)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053072293&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2003/51/i06/abs/jf0209138.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of ephedrine alkaloids and synephrine in dietary supplements by column-switching cation exchange high-performance liquid chromatography with scanning-wavelength ultraviolet and fluorescence detection.
AU - Niemann, R. A.
AU - Gay, M. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2003///
VL - 51
IS - 19
SP - 5630
EP - 5638
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Niemann, R. A.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063040785. Publication Type: Journal Article. Language: English. Registry Number: 299-42-3, 50-98-6, 134-72-5. Subject Subsets: Human Nutrition; Postharvest Research
N2 - An HPLC method with on-line cleanup coupled to the separation column is described for determination of (-)-norephedrine, (+)-norpseudoephedrine, (-)-ephedrine, (+)-pseudoephedrine, (-)-N-methylephedrine, (+)-N-methylpseudoephedrine, and (±)-synephrine in finished dietary supplement products. Test portions were extracted in acidified aqueous acetone. A filtered aliquot was cleaned up on a strong cation exchange (SCX) precolumn that later was automatically coupled to the SCX analytical column. Measurement was by full-scan UV spectra for confirmation of identity by spectral matching and real-time integration of three wavelength signals for multiple quantitation. (±)-Synephrine was also quantitated by native fluorescence. Recovery averaged 95-100%. Determination of the major ingredients (-)-ephedrine, (+)-pseudoephedrine, and (±)-synephrine compared favorably to findings by an independent LC-MS analysis for a set of 25 samples. The results of a survey were reported for total ephedrine alkaloid and synephrine content and were compared to content declaration, for ~48 finished products.
KW - adulteration
KW - analytical methods
KW - determination
KW - ephedrine
KW - food contamination
KW - food safety
KW - food supplements
KW - HPLC
KW - analytical techniques
KW - food contaminants
KW - high performance liquid chromatography
KW - methylephedrine
KW - methylpseudoephedrine
KW - norpseudoephedrine
KW - pseudoephedrine
KW - synephrine
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063040785&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2003/51/i19/abs/jf0302052.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rugged LC-MS/MS survey analysis for acrylamide in foods.
AU - Roach, J. A. G.
AU - Andrzejewski, D.
AU - Gay, M. L.
AU - Nortrup, D.
AU - Musser, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2003///
VL - 51
IS - 26
SP - 7547
EP - 7554
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Roach, J. A. G.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063060865. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The described liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection of acrylamide in food entails aqueous room temperature extraction, SPE cleanup, and analysis by LC-MS/MS. The method is applicable to a wide variety of foods. [13C3]acrylamide is the internal standard. The limit of quantitation is 10 ppb (µg/kg). Data were obtained in duplicate from >450 products representing >35 different food types. The variability in analyte levels in certain food types suggests that it may be possible to reduce acrylamide levels in those foods.
KW - acrylamides
KW - food safety
KW - foods
KW - liquid chromatography
KW - mass spectrometry
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063060865&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2003/51/i26/abs/jf0346354.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibiotic susceptibilities of Gram-positive anaerobic cocci: results of a sentinel study in England and Wales.
AU - Brazier, J. S.
AU - Hall, V.
AU - Morris, T. E.
AU - Gal, M.
AU - Duerden, B. I.
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2003///
VL - 52
IS - 2
SP - 224
EP - 228
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Brazier, J. S.: Anaerobe Reference Laboratory, National Public Health Service Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff CF14 4XW, UK.
N1 - Accession Number: 20033175213. Publication Type: Journal Article. Language: English. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 33564-30-6, 35607-66-0, 56-75-7, 58001-44-8, 18323-44-9, 114-07-8, 64221-86-9, 443-48-1, 61477-96-1, 89786-04-9, 60-54-8, 64-75-5. Subject Subsets: Public Health
N2 - Objective: A sentinel study was carried out to determine the antimicrobial susceptibilities of Gram-positive anaerobic cocci (GPAC) freshly isolated from clinical material in diagnostic laboratories in England and Wales. Methods: A total of 113 GPAC isolates consisting predominantly of current or former members of the genus Peptostreptococcus was obtained from 17 sentinel laboratories in England and one in Wales. Minimum inhibitory concentrations (MICs) of 10 antimicrobial agents were determined by the Etest method. The agents tested were: penicillin, tetracycline, erythromycin, cefoxitin, clindamycin, chloramphenicol, imipenem, co-amoxiclav, piperacillin/tazobactam and metronidazole. MIC50 and MIC90 values for each drug-species combination were calculated whenever suitable numbers of each species were obtained. Results: Excellent spectra of activity (0% resistance) against GPAC were seen for metronidazole, piperacillin/tazobactam, cefoxitin, imipenem and chloramphenicol. Low degrees of resistance to co-amoxiclav (3.5%), clindamycin (7.1%), penicillin (7.1%) and significant degrees of resistance to tetracycline (41.6%) and erythromycin (27.4%) were detected. Some examples of putative macrolide-lincosamide linked resistance were noted in seven (6.2%) isolates of GPAC. Conclusion: This study is one of the largest susceptibility studies specifically on GPAC carried out to date and the resulting data may be of value to those involved in the empirical treatment of infections involving Gram-positive anaerobic cocci.
KW - amoxicillin
KW - antibacterial agents
KW - bacterial diseases
KW - cefoxitin
KW - chloramphenicol
KW - clavulanic acid
KW - clindamycin
KW - erythromycin
KW - human diseases
KW - imipenem
KW - metronidazole
KW - multiple drug resistance
KW - piperacillin
KW - tazobactam
KW - tetracycline
KW - England
KW - UK
KW - Wales
KW - man
KW - Peptostreptococcus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Peptostreptococcaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - achromycin
KW - amoxycillin
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - penicillin
KW - United Kingdom
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033175213&site=ehost-live&scope=site
UR - http://jac.oupjournals.org/cgi/content/abstract/52/2/224
UR - email: Brazier@Cardiff.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved recovery of pathogenic Vibrio parahaemolyticus from oysters using colony hybridization following enrichment.
AU - Nordstrom, J. L.
AU - DePaola, A.
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2003///
VL - 52
IS - 2
SP - 273
EP - 277
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0167-7012
AD - Nordstrom, J. L.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Post Office Box 158, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033032049. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science; Veterinary Science
N2 - The traditional streak plating and alternative spread-plating methods were compared for detection of pathogenic Vibrio parahaemolyticus (Vp) in oyster enrichments. We found the alternative method to be more efficient: it was quicker (2d vs. 3d) and had a significantly (p<0.05) greater detection rate than streak plating.
KW - detection
KW - methodology
KW - oysters
KW - recovery
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - methods
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033032049&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T30-46YXPPW-3&_user=10&_handle=W-WA-A-A-AB-MsSAYVA-UUW-AUVDEDYBWV-DCUZUDUCC-AB-U&_fmt=summary&_coverDate=02%2F28%2F2003&_rdoc=12&_orig=browse&_srch=%23toc%234932%232003%23999479997%23366886!&_cdi=4932&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dfa4cf4a66b488a08bb81526143214c3
UR - email: jessica.nordstrom@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi.
AU - Gilmore, R. D., Jr.
AU - Bacon, R. M.
AU - Carpio, A. M.
AU - Piesman, J.
AU - Dolan, M. C.
AU - Mbow, M. L.
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
Y1 - 2003///
VL - 52
IS - 7
SP - 551
EP - 556
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0022-2615
AD - Gilmore, R. D., Jr.: Molecular Bacteriology Section, Bacterial Zoonoses Branch, Division of Vector-Borne Infectious Diseases (DVBID), National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, Colorado, USA.
N1 - Accession Number: 20033117842. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology
N2 - A one-inoculation regimen of recombinant outer-surface protein C (OspC), which has been demonstrated to elicit protective immunity against a tick-borne challenge of Borrelia burgdorferi, was administered to outbred mice. Following seroconversion, the serum antibody titre against OspC was allowed to wane with time until there was little or no detection of anti-OspC antibodies by immunoblot. The mice were then challenged with an infectious dose of B. burgdorferi by tick transmission. Eleven of 12 OspC-primed mice subsequently became infected by B. burgdorferi, demonstrating that a protective anamnestic response was not generated in these mice following the introduction of infectious OspC-expressing spirochaetes.
KW - animal models
KW - immune response
KW - Lyme disease
KW - surface proteins
KW - tickborne diseases
KW - Borrelia burgdorferi
KW - mice
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - lyme borreliosis
KW - membrane proteins
KW - Animal Immunology (LL650) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033117842&site=ehost-live&scope=site
UR - email: rbg9@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Six interaction profiles for simple mixtures.
AU - Pohl, H. R.
AU - Roney, N.
AU - Wilbur, S.
AU - Hansen, H.
AU - Rosa, C. T. de
T3 - Persistent Organic Pollutants and Dioxins.
JO - Chemosphere
JF - Chemosphere
Y1 - 2003///
VL - 53
IS - 2
SP - 183
EP - 197
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0045-6535
AD - Pohl, H. R.: Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Div. of Toxicology, Mailstop E-29, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20043037847. Publication Type: Journal Article. Note: Persistent Organic Pollutants and Dioxins. Language: English. Number of References: many ref. Registry Number: 7440-38-2, 71-43-2, 7440-43-9, 7440-47-3, 7440-50-8, 118-74-1, 7439-92-1, 7439-96-5, 108-88-3, 79-01-6, 1330-20-7, 7440-66-6. Subject Subsets: Plant Pathology
N2 - The Agency for Toxic Substances and Disease Registry (ATSDR) has a programme for chemical mixtures that encompasses research on chemical mixtures toxicity, health risk assessment, and development of innovative computational methods. ATSDR prepared a guidance document that instructs users on how to conduct health risk assessment on chemical mixtures (Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures). ATSDR also developed six interaction profiles for chemical mixtures. Two profiles were developed for persistent environmental chemicals that are often found in contaminated fish and also can be detected in human breast milk. The mixture included chlorinated dibenzo-p-dioxins, hexachlorobenzene, dichlorodiphenyl dichloroethane, methyl mercury, and polychlorinated biphenyls. Two profiles each were developed for mixtures of metals and mixtures of volatile organic chemicals (VOCs) that are frequently found at hazardous waste sites. The two metal profiles dealt with (a) lead, manganese, zinc, and copper; and (b) arsenic, cadmium, chromium, and lead; the two VOCs mixtures dealt with (a) 1,1,1-trichloroethane, 1,1-dichloroethane, trichloroethylene, and tetrachloroethylene; and (b) benzene, ethylbenzene, toluene, and xylenes (BTEX). Weight-of-evidence methodology was used to evaluate the joint toxic action for most of the mixtures. Physiologically based pharmacokinetic modelling was used for BTEX. In most cases, a target-organ toxicity rate modification of the hazard index approach is recommended for conducting exposure-based assessments of noncancer health hazards.
KW - arsenic
KW - benzene
KW - cadmium
KW - carcinogens
KW - chromium
KW - contaminants
KW - copper
KW - dioxins
KW - health hazards
KW - heavy metals
KW - hexachlorobenzene
KW - interactions
KW - lead
KW - manganese
KW - pesticide residues
KW - pollutants
KW - polychlorinated biphenyls
KW - risk assessment
KW - toluene
KW - toxic substances
KW - toxicity
KW - trichloroethylene
KW - xylene
KW - zinc
KW - dimethylbenzene
KW - HCB
KW - Mn
KW - PCBs
KW - poisons
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Industrial Wastes and Effluents (XX400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043037847&site=ehost-live&scope=site
UR - email: hpohl@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of foodborne bacteria by infrared spectroscopy using cellular fatty acid methyl esters.
AU - Whittaker, P.
AU - Mossoba, M. M.
AU - Al-Khaldi, S.
AU - Fry, F. S.
AU - Dunkel, V. C.
AU - Tall, B. D.
AU - Yurawecz, M. P.
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2003///
VL - 55
IS - 3
SP - 709
EP - 716
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0167-7012
AD - Whittaker, P.: Division of Research and Applied Technology, ONPLDS, Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20033216580. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases
N2 - Identification of bacterial species by profiling fatty acid methyl esters (FAMEs) has commonly been carried out by using a 20-min capillary gas chromatographic procedure followed by library matching of FAME profiles using commercial MIDI databases and proprietary pattern recognition software. Fast GC (5 min) FAME procedures and mass spectrometric methodologies that require no lipid separation have also been reported. In this study, bacterial identification based on the rapid (2 min) infrared measurement of FAME mixtures was demonstrated. The microorganisms investigated included Gram positive bacteria Staphylococcus aureus, Listeria monocytogenes, Bacillus anthracis, and Bacillus cereus, and Gram negative bacteria from the family Enterobacteriacae: Yersinia enterocolitica, Salmonella typhimurium, Shigella sonnei, and Escherichia coli (four strains of E. coli), and non-Enterobacteriacae: Vibrio cholerae, Vibrio vulnificus, and Vibrio parahemolyticus. Foodborne bacterial mixtures of FAMEs were measured by using an attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopic procedure and discriminated by multivariate analysis. Results showed that the Enterobacteriacae could be discriminated from the vibrios. The identification was at the level of species (for the Bacillus and Vibrio genera) or strains (for the E. coli species). A series of bacterial FAME test samples were prepared and analysed for accuracy of identification, and all were correctly identified. Our results suggest that this infrared strategy could be used to identify foodborne pathogens.
KW - fatty acid esters
KW - food safety
KW - Gram negative bacteria
KW - Gram positive bacteria
KW - identification
KW - infrared spectroscopy
KW - microbiological techniques
KW - multivariate analysis
KW - principal component analysis
KW - Bacillus anthracis
KW - Bacillus cereus
KW - Bacteria
KW - Enterobacteriaceae
KW - Escherichia coli
KW - Listeria monocytogenes
KW - Salmonella typhimurium
KW - Shigella sonnei
KW - Staphylococcus aureus
KW - Vibrio cholerae
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Yersinia enterocolitica
KW - Bacteria
KW - prokaryotes
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Escherichia
KW - Enterobacteriaceae
KW - Listeria
KW - Listeriaceae
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Shigella
KW - Staphylococcus
KW - Staphylococcaceae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Yersinia (Bacteria)
KW - bacterium
KW - E. coli
KW - Fourier Transform infrared spectroscopy
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033216580&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T30-49NY0C3-2&_user=10&_handle=W-WA-A-A-BE-MsSAYWA-UUA-AUDVUCYBVY-AYBDCEBVE-BE-U&_fmt=summary&_coverDate=12%2F31%2F2003&_rdoc=16&_orig=browse&_srch=%23toc%234932%232003%23999449996%23469055!&_cdi=4932&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f9a7df07f5c377509ea455818d42c1f1
UR - email: mmossoba@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effect of structural characteristics on family planning program performance in Côte d'Ivoire and Nigeria.
AU - Mancini, D. J.
AU - Stecklov, G.
AU - Stewart, J. F.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2003///
VL - 56
IS - 10
SP - 2123
EP - 2137
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0277-9536
AD - Mancini, D. J.: FDA/Center for Food Safety and Applied Nutrition, HFS-726, Room 2D-035, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20033074898. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - This paper uses Côte d'Ivoire and Nigeria survey data on both supply and demand characteristics to examine how structural and demographic factors influence family planning provision and cost. The model, which takes into account the endogenous influence of service provision on average cost, explains provision well but poorly explains what influences service cost. We show that both size and specialization matter. In both countries, vertical (exclusive family planning) facilities provide significantly more contraception than integrated medical establishments. In the Nigeria sample, larger facilities also offer services at lower average cost. Since vertical facilities tend to be large, they at most incur no higher unit costs than integrated facilities. These results are consistent across most model specifications, and are robust to corrections for endogenous facility placement in Nigeria. Model results and cost recovery information point to the relative efficiency of the International Planned Parenthood Federation, which operates large, mostly vertically organized facilities.
KW - contraception
KW - costs
KW - family planning
KW - health centres
KW - health services
KW - Cote d'Ivoire
KW - Nigeria
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Developing Countries
KW - Francophone Africa
KW - Africa
KW - West Africa
KW - Africa South of Sahara
KW - Anglophone Africa
KW - Commonwealth of Nations
KW - birth control
KW - costings
KW - health centers
KW - Ivory Coast
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033074898&site=ehost-live&scope=site
UR - email: dominic.mancini@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enteroviruses and type 1 diabetes mellitus.
AU - Haverkos, H. W.
AU - Battula, N.
AU - Drotman, D. P.
AU - Rennert, O. M.
JO - Biomedicine & Pharmacotherapy
JF - Biomedicine & Pharmacotherapy
Y1 - 2003///
VL - 57
IS - 9
SP - 379
EP - 385
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 0753-3322
AD - Haverkos, H. W.: Center for Drug Evaluation and Research, Food and Drug Administration, HFD-530, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20043008625. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Despite decades of research, the etiology of type 1 diabetes mellitus (DM) is unknown. Several risk factors have been associated with type 1 DM, including viral infections, genetic predisposition, nutritional factors, and chemicals. Several investigators hypothesize that the etiologies of type 1 DM result from a complex interaction of genetic and environmental factors. In this paper we review the epidemiologic data linking enteroviruses to type 1 DM and discuss potential mechanisms of pathogenesis.
KW - diabetes mellitus
KW - epidemiology
KW - human diseases
KW - pathogenesis
KW - reviews
KW - risk factors
KW - viral diseases
KW - Enterovirus
KW - man
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043008625&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VKN-49KGW3V-1&_user=10&_handle=W-WA-A-A-E-MsSAYZA-UUW-AUDCBCVEBE-WUEEZUCDY-E-U&_fmt=summary&_coverDate=11%2F30%2F2003&_rdoc=1&_orig=browse&_srch=%23toc%236127%232003%23999429990%23472305!&_cdi=6127&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d0104b483611b162ea418412bbfa8357
UR - email: haverkosh@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CFSAN's program priorities: from food safety to food security.
AU - Levitt, J. A.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 2003///
VL - 58
IS - 1
SP - 19
EP - 24
CY - Washington; USA
PB - Food and Drug Law Institute
SN - 1064-590X
AD - Levitt, J. A.: Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20043016266. Publication Type: Journal Article. Language: English. Number of References: 11 notes and ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - This paper provides an overview of the Food and Drug Administration's role in food security and in preventing the intentional introduction of pathogens or harmful chemicals into the food supply. The major food safety systems currently in place (surveillance systems, prevention programs, outbreak response) are described and new efforts meant to bolster security even further are outlined.
KW - food contamination
KW - food safety
KW - food security
KW - food supply
KW - microbial contamination
KW - nutrition programmes
KW - regulations
KW - reviews
KW - surveillance
KW - feeding programmes
KW - feeding programs
KW - food contaminants
KW - food programs
KW - nutrition programs
KW - rules
KW - Agencies and Organizations (DD100)
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043016266&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Workplace exacerbation of asthma symptoms: findings from a population-based study in Maine.
AU - Henneberger, P, K.
AU - Deprez, R. D.
AU - Asdigian, N.
AU - Oliver, L. C.
AU - Derk, S.
AU - Goe, S. K.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 2003///
VL - 58
IS - 12
SP - 781
EP - 788
CY - Washington; USA
PB - Heldref Publications
SN - 0003-9896
AD - Henneberger, P, K.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), M/S H-2800, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053086261. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - In this population-based study of asthma in the State of Maine, the authors investigated how often asthma symptoms were exacerbated in the workplace. Participants from 5 hospital service areas in Maine completed a telephone questionnaire. Of 474 adult participants (18-65 yr of age) employed during the preceding year and for whom information on occupation and industry was available, 64 (13.5%) were identified with current asthma, including 28 (5.9%) with current physician-diagnosed asthma and 36 (7.6%) who met criteria for symptoms consistent with asthma. Jobs were identified a priori as "high-risk" or "low-risk" for asthma. Of the 64 asthma cases, 16 (25%) reported that their coughing or wheezing worsened at work. Among the symptom-based cases, the percentage with workplace exacerbation of asthma was elevated for high-risk jobs (7/14=50%) vs. low-risk jobs (3/22=13.6%) (p=0.03). No similar elevation was observed for individuals with current physician-diagnosed asthma, which might have resulted, in part, from a healthy worker effect.
KW - asthma
KW - human diseases
KW - occupational hazards
KW - Maine
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053086261&site=ehost-live&scope=site
UR - email: pkh0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use.
AU - Calvo, M. S.
AU - Whiting, S. J.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2003///
VL - 61
IS - 3
SP - 107
EP - 113
CY - Lawrence; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Calvo, M. S.: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-025, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20033071987. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1406-16-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - Several recent studies have identified a surprisingly high prevalence of vitamin D insufficiency in otherwise healthy adults living in Canada and the United States. Most striking are the effects of latitude, season, and race. Also noteworthy is that dietary vitamin D is not reaching the population in greatest need, nor is it very protective against insufficiency. Fluid milk, as the predominant vehicle for vitamin D fortification, is apparently not very effective in staving off vitamin D insufficiency in adults in all populations at all times of the year.
KW - diets
KW - ethnicity
KW - food supplements
KW - foods
KW - fortification
KW - latitude
KW - milk
KW - nutrient deficiencies
KW - reviews
KW - seasons
KW - vitamin D
KW - Canada
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - food fortification
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033071987&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health indicators in a prison population: asking prisoners.
AU - Lester, C.
AU - Hamilton-Kirkwood, L.
AU - Jones, N. K.
JO - Health Education Journal
JF - Health Education Journal
Y1 - 2003///
VL - 62
IS - 4
SP - 341
EP - 349
CY - London; UK
PB - Health Education Journal Limited
SN - 0017-8969
AD - Lester, C.: Health Inequalities and Equity, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK.
N1 - Accession Number: 20043000749. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Objective: To collect information on health determinants directly from prisoners, complementary to a needs assessment. Design: Self-completion multiple-choice questionnaire to a sample based on alternate cells. Setting: Her Majesty's Prison (HMP) Cardiff, UK [date not given]. Method: 300 men received questionnaires with an offer of confidential help, which was accepted by 2. Questions included qualifications, previous occupation, drug, alcohol and medical history, smoking, perceived threats, worries, diet, exercise, drugs in prison, access to services, and the Hospital Anxiety and Depression (HAD) scale. Results: Of 133 (44%) who responded, more than half had left school prematurely. 33 (25%) drank 90 alcohol units or more weekly before prison and 91 (68%) used illegal drugs, with 44 (33%) using in prison. Of the 112 (84%) who smoked, 89 (79%) wished to quit. 91 (68%) never took vigorous exercise, and 83 (62%) ate less than 3 portions of fruit and/or vegetables daily. Only 41 (35%) were within the normal HAD range for both anxiety and depression. Conclusion: This study highlights concurrent high levels of adverse health determinants in prisoners. Targeting these determinants should improve health and decrease the chance of returning to criminality on release.
KW - alcoholism
KW - anxiety
KW - correctional institutions
KW - depression
KW - diet
KW - drug abuse
KW - educational performance
KW - exercise
KW - health
KW - human diseases
KW - men
KW - mental disorders
KW - prisoners
KW - tobacco smoking
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - drug use
KW - mental illness
KW - psychiatric disorders
KW - United Kingdom
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Nutrition (General) (VV100)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043000749&site=ehost-live&scope=site
UR - email: Carolyn.lester@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stilbenes from the roots of Pleuropterus ciliinervis and their antioxidant activities.
AU - Lee JongPill
AU - Min ByungSun
AU - An RenBo
AU - Na MinKyun
AU - Lee SangMyung
AU - Lee HyeongKyu
AU - Kim JaeGil
AU - Bae KiHwan
AU - Kang SamSik
JO - Phytochemistry
JF - Phytochemistry
Y1 - 2003///
VL - 64
IS - 3
SP - 759
EP - 763
CY - Oxford; UK
PB - Pergamon Press
SN - 0031-9422
AD - Lee JongPill: Korea Food and Drug Administration, 122-704, Seoul, Korea Republic.
N1 - Accession Number: 20033180379. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Two stilbene glycosides, pieceid-2″-O-gallate and pieceid-2″-O-coumarate, were isolated from the MeOH extract of the roots of Pleuropterus ciliinervis [Fallopia multiflora var. ciliinervis] (collected from Chungnam, Korea Republic) Nakai (Polygonaceae), together with two known compounds, resveratrol and pieceid. Their structures were determined spectroscopically, particularly by 2D NMR spectroscopic analysis. The antioxidant activities of stilbenes isolated were determined in vitro against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, superoxide radicals and by determining their lipid peroxidation inhibitory activities. Among the compounds isolated, pieceid-2″-O-gallate had the most potent inhibitory scavenging effect on DPPH, superoxide radicals and upon lipid peroxidation inhibition with IC50 values of 16.5, 23.9 and 5.1 µM, respectively.
KW - antioxidant properties
KW - chemical composition
KW - free radicals
KW - lipid peroxidation
KW - plant composition
KW - plant extracts
KW - stilbenes
KW - Korea Republic
KW - Polygonaceae
KW - Polygonales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Fallopia
KW - Polygonaceae
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - anti-oxidant properties
KW - chemical constituents of plants
KW - Fallopia multiflora
KW - South Korea
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033180379&site=ehost-live&scope=site
UR - email: baekh@cnu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of methods to improve detection of Escherichia coli O157:H7 in fresh produce by multiplex polymerase chain reaction.
AU - Grant, M. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 1
SP - 18
EP - 24
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Grant, M. A.: U.S. Food and Drug Administration, Bothell, WA 98021-4421, USA.
N1 - Accession Number: 20033029397. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Postharvest Research
N2 - Multiplex polymerase chain reaction (PCR) analysis was used to detect 2 genes encoding Shiga-like toxins (stx1 and stx2) and a universal Escherichia coli gene (gadA/B) in fresh produce spiked with E. coli O157:H7. Current U.S. Food and Drug Administration procedures for the analysis of fresh produce include the use of the rinsate from an initial rinse for the analysis of several potential pathogens, including E. coli O157:H7. In this study, several procedures were evaluated for their ability to increase the sensitivity of PCR analysis of rinsates from 15 types of produce. The procedures evaluated included the preliminary clarification and concentration of templates by centrifugation and the treatment of templates with compounds reported to facilitate nucleic acid amplification, including polyvinlypolypyrrolidone (PVPP), nonfat dry milk (NFDM), and InstaGene. The preliminary concentration of rinsates resulted in moderate improvements in detection sensitivity. The use of PVPP-treated templates in PCR reaction mixtures did not further improve sensitivity, but the inclusion of NFDM-treated templates increased sensitivity by an order of magnitude for 12 rinsates. The incorporation of InstaGene also improved the detection capability of the analysis; this procedure yielded the strongest gel bands for 8 rinsates. However, for 4 other rinsates, the use of this reagent decreased sensitivity; these 4 rinsates were those for the produce varieties with the largest surface areas and were the most turbid rinsates. The use of facilitating compounds to block PCR inhibition may enable an analysis for Shiga toxin-producing E. coli in fresh produce to be completed in 1 to 2 days, rather than the 5 days required for current methods.
KW - detection
KW - food contamination
KW - fruits
KW - microbial contamination
KW - pathogens
KW - polymerase chain reaction
KW - vegetables
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - food contaminants
KW - PCR
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033029397&site=ehost-live&scope=site
UR - email: mgrant@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.
AU - Calvert, R. J.
AU - Tepper, S.
AU - Diwan, B. A.
AU - Anderson, L. M.
AU - Kritchevsky, D.
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2003///
VL - 66
IS - 3
SP - 393
EP - 403
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0006-2952
AD - Calvert, R. J.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20033148213. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 57-88-5, 11041-12-6, 59-67-6. Subject Subsets: Human Nutrition
N2 - Hypocholesterolemic drugs may themselves increase (cholestyramine, CS) or decrease (lovastatin, Lov) peripheral tissue de novo cholesterol biosynthesis. This will alter the abundance of prenyl groups and potentially increase (CS) or decrease (Lov) K-ras membrane localization, with possible pro- or anti-carcinogenic effects (K-ras is a proto-oncogene frequently mutated in lung cancer). Female A/J, Swiss, and C57BL/6 mice were fed 2 or 4% CS, 1% niacin, or injected with Lov three (Lov-3×) or five (Lov-5×) times per week. After three weeks, serum cholesterol and triglycerides were determined enzymatically. Total, membrane, and cytoplasmic K-ras proteins were determined in lung homogenates by immunoprecipitation followed by Western blotting with a K-ras specific antibody. CS feeding increased membrane K-ras as hypothesized in A/J and C57BL/6 mice, but had no effect in Swiss mice. Lov failed in all three strains to reduce membrane K-ras, and resulted in an increase in total K-ras in A/J and C57BL/6 mice, while again lacking effect in Swiss mice. Niacin had no effect on K-ras protein in any mouse strain. These results differ from our published results for male mice of the same strains, particularly for A/J mice. Increased amounts of K-ras protein in the membrane fraction of A/J females (but not males) treated with either Lov or CS imply that if K-ras were to become mutated, CS could result in increased lung tumorigenesis and Lov would be less likely to be protective in females. In the light of these data, both sexes should be included in future animal and human chemoprevention trials.
KW - animal models
KW - cholesterol
KW - colestyramine
KW - females
KW - human diseases
KW - laboratory animals
KW - lung cancer
KW - lungs
KW - males
KW - neoplasms
KW - nicotinic acid
KW - proto-oncogenes
KW - sex differences
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anticholesteraemic agents
KW - cancers
KW - cholestyramine
KW - lovastatin
KW - niacin
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033148213&site=ehost-live&scope=site
UR - email: calvert@mail.ncifcrf.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation and interlaboratory validation of a selective agar for phosphatidylinositol-specific phospholipase C activity using a chromogenic substrate to detect Listeria monocytogenes from foods.
AU - Jinneman, K. C.
AU - Hunt, J. M.
AU - Eklund, C. A.
AU - Wernberg, J. S.
AU - Sado, P. N.
AU - Johnson, J. M.
AU - Richter, R. S.
AU - Torres, S. T.
AU - Ayotte, E.
AU - Eliasberg, S. J.
AU - Istafanos, P.
AU - Bass, D.
AU - Kexel-Calabresa, N.
AU - Lin, W.
AU - Barton, C. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 3
SP - 441
EP - 445
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jinneman, K. C.: Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory-Northwest, 22201 23rd Drive S.E., Bothell, WA 98021, USA.
N1 - Accession Number: 20033045922. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 9002-18-0, 9001-86-9.
N2 - Phosphatidylinositol-specific phospholipase C (PI-PLC) activity is a potential virulence factor and is exhibited only by the Listeria species Listeria monocytogenes and Listeria ivanovii. A chromogenic substrate for the direct detection of PI-PLC activity is available in a new medium (BCM L. monocytogenes plating agar). The use of a chromogenic substrate offers a mechanism with which to directly screen for L. monocytogenes and L. ivanovii other than the aesculin used in Oxford (OXF) and Palcam (PAL) agars, which screen for all Listeria species. The specificity levels of BCM plating agar and of BCM confirmation and rhamnose agars were evaluated with 107 Listeria and 10 Bacillus species isolates. In addition, BCM L. monocytogenes plating agar was compared with standard Listeria selective agars (OXF and PAL agars) with regard to the recovery of L. monocytogenes from 2000 food and environmental samples obtained from 8 participating laboratories. A Listeria species was isolated from at least one of the agars in 209 analyses, and L. monocytogenes was isolated in 135 of these analyses. In 27 of the analyses in which L. monocytogenes was isolated, one or more of the selective differential agars used failed to isolate L. monocytogenes, and therefore the results of these analyses were discrepant. Relative to a reference method involving the use of all 3 agars (OXF, PAL, and BCM agars), the OXF-BCM, PAL-BCM, and OXF-PAL combinations had sensitivities of 99.3, 99.2, and 90.2%, respectively. In statistical analyses of the different combinations of agars, the OXF-BCM and BCM-PAL combinations were found to be superior to the OXF-PAL combination for the detection of L. monocytogenes.
KW - agar
KW - culture media
KW - detection
KW - enzyme activity
KW - enzymes
KW - evaluation
KW - food contamination
KW - foods
KW - microbial contamination
KW - phosphatidylinositols
KW - phospholipase C
KW - Listeria ivanovii
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033045922&site=ehost-live&scope=site
UR - email: kjinnema@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Apple quality, storage, and washing treatments affect patulin levels in apple cider.
AU - Jackson, L. S.
AU - Beacham-Bowden, T.
AU - Keller, S. E.
AU - Adhikari, C.
AU - Taylor, K. T.
AU - Chirtel, S. J.
AU - Merker, R. I.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 4
SP - 618
EP - 624
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jackson, L. S.: National Center for Food Safety and Technology, Food and Drug Administration, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033068017. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 149-29-1. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research
N2 - Patulin is a mycotoxin produced primarily by Penicillium expansum, a mould responsible for rot in apples and other fruits. The growth of this fungus and the production of patulin are common in fruit that has been damaged. However, patulin can be detected in visibly sound fruit. The purpose of this project was to determine how apple quality, storage, and washing treatments affect patulin levels in apple cider. Patulin was not detected in cider pressed from fresh tree-picked apples (seven cultivars) but was found at levels of 40.2 to 374 µg/litre in cider pressed from four cultivars of fresh ground-harvested (dropped) apples. Patulin was not detected in cider pressed from culled tree-picked apples stored for 4 to 6 weeks at 0 to 2°C but was found at levels of 0.97 to 64.0 µg/litre in cider pressed from unculled fruit stored under the same conditions. Cider from controlled-atmosphere-stored apples that were culled before pressing contained 0 to 15.1 µg of patulin per litre, while cider made from unculled fruit contained 59.9 to 120.5 µg of patulin per litre. The washing of ground-harvested apples before pressing reduced patulin levels in cider by 10 to 100%, depending on the initial patulin levels and the type of wash solution used. These results indicate that patulin is a good indicator of the quality of the apples used to manufacture cider. The avoidance of ground-harvested apples and the careful culling of apples before pressing are good methods for reducing patulin levels in cider.
KW - apples
KW - cider
KW - controlled atmosphere storage
KW - food quality
KW - patulin
KW - washing
KW - Malus
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033068017&site=ehost-live&scope=site
UR - email: lauren.jackson@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of temperature on the growth response of Salmonella enteritidis inoculated onto the vitelline membranes of fresh eggs.
AU - Fleischman, G. J.
AU - Napier, C. L.
AU - Stewart, D.
AU - Palumbo, S. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 8
SP - 1368
EP - 1373
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Fleischman, G. J.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033138793. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 9006-50-2.
N2 - The growth response of Salmonella enteritidis (SE) on the vitelline membrane in vitro was studied with the use of a special tube devised specifically for the inoculation of SE onto the vitelline membrane and for the sampling of the yolk near the inoculation site. This latter ability allowed the detection of the movement of SE into the yolk. The growth of SE on the membrane was compared with that of SE inoculated into yolk and albumen in vitro and in ovo in fresh in-shell eggs. The incubation time was 2 days, and the incubation temperatures were 4, 8, 15, 27, and 37°C. Comparison of the results obtained for in vitro growth showed that at 4, 8, and 15°C, SE behaved as if it were in the albumen, with its numbers decreasing over time. At 27 and 37°C, SE grew as if it were in yolk, with a maximum increase of 4.5 log CFU after 2 days at 37°C. In no experiments involving growth on the vitelline membrane did SE appear in the yolk. Comparisons between in vitro and in ovo growth responses of SE in yolk and albumen indicate that SE growth on the membrane parallels that in the in-shell egg.
KW - egg albumen
KW - egg yolk
KW - eggs
KW - food contamination
KW - food safety
KW - growth
KW - microbial contamination
KW - temperature
KW - vitelline membrane
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - egg white
KW - food contaminants
KW - yolk
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033138793&site=ehost-live&scope=site
UR - email: gfleisch@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inactivation of Clostridium botulinum type A spores by high-pressure processing at elevated temperatures.
AU - Reddy, N. R.
AU - Solomon, H. M.
AU - Tetzloff, R. C.
AU - Rhodehamel, E. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 8
SP - 1402
EP - 1407
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Reddy, N. R.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20033138798. Publication Type: Journal Article. Language: English. Number of References: 47 ref.
N2 - The effects of high-pressure treatments at various temperature-time combinations on the inactivation of spores of Clostridium botulinum type A strains 62-A and BS-A in phosphate buffer (0.067 M, pH 7.0) and in a crabmeat blend were investigated. The log unit reduction of strain 62-A spores increased significantly as the processing pressure increased from 417 to 827 MPa (from 60 000 to 120 000 lb/in2) at 75°C. The reduction of BS-A and 62-A spores in either medium increased as processing temperatures increased from 60 to 75°C and processing times increased from 5 to 15 or 20 minutes at a maximum pressure of 827 MPa. Approximately 2- and 3-log reductions of BS-A and 62-A spores, respectively, in phosphate buffer were obtained at the maximum pressure-maximum temperature combination of 827 MPa and 75°C for a processing time of 20 minutes. Processing for 15 minutes at the maximum pressure-maximum temperature combination resulted in maximum reductions of 3.2 and 2.7 log units for BS-A and 62-A spores, respectively, in the crabmeat blend. Results obtained in this study indicate that the crabmeat blend did not protect BS-A and 62-A spores against inactivation by high-pressure processing.
KW - bacterial spores
KW - crab meat
KW - food contamination
KW - food processing
KW - food safety
KW - inactivation
KW - microbial contamination
KW - pressure treatment
KW - temperature
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Aquatic Produce (QQ060)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbiology (General) (ZZ390)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033138798&site=ehost-live&scope=site
UR - email: rukma.reddy@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermal inactivation, growth, and survival studies of Listeria monocytogenes strains belonging to three distinct genotypic lineages.
AU - Jesús, A. J. de
AU - Whiting, R. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 9
SP - 1611
EP - 1617
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jesús, A. J. de: U.S. Food and Drug Administration/Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20033156540. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - 21 Listeria monocytogenes strains belonging to three different genotypic lineages were evaluated for differences between lineages and between individual strains with respect to thermal inactivation, growth, and survival. Three sets of heat inactivation conditions (60°C, pH 6.0, and 0.5 M lactate; 55°C, pH 6.0, and 0.5 M lactate; and 50°C, pH 4.0, and 0.5 M lactate) were used on strains grown in modified brain heart infusion (BHI) broth with and without glucose. Two sets of growth conditions (35°C, pH 6.5, and 0.1 M lactate and 5°C, pH 6.5, and 0.1 M lactate) were used with modified BHI broths to determine lag phases and exponential growth rates. Two sets of conditions (28°C, pH 4.0, and 1 M lactate and 28°C, pH 4.5, and 0.5 M lactate) were used with modified BHI broth to determine survival times (D-values). Thermal inactivation D-values were consistently lowest for lineage III, but differences were not significant for any set of conditions tested. Some significant differences were observed between lineages with respect to some of the growth and survival conditions tested. Extensive strain-to-strain variation was observed for all parameters tested. Average coefficients of variation for the thermal inactivation, growth, and survival studies were 0.31, 0.18, and 0.26, respectively. Strain-to-strain variations were approximately equal to the uncertainties associated with the analytical procedures. The results obtained indicate a diversity among strains encountered in food processing that must be accounted for in process calculations and risk assessments.
KW - genotypes
KW - growth
KW - heat treatment
KW - inactivation
KW - strains
KW - survival
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - heat processing
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033156540&site=ehost-live&scope=site
UR - email: adejesus@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of homogenization methods for recovering Salmonella Enteritidis from eggs.
AU - Seo, K. H.
AU - Brackett, R. E.
AU - Valentín-Bon, I. E.
AU - Holt, P. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 9
SP - 1666
EP - 1669
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Seo, K. H.: U.S Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods and Beverages, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20033156548. Publication Type: Journal Article. Language: English. Number of References: 16 ref.
N2 - For Salmonella Enteritidis (SE) detection, shell eggs have been homogenized with stomachers, with electric blenders, and by hand massaging. However, to date, there have been no published reports addressing whether the method of homogenization affects the recovery of SE from raw eggs. Three inoculum levels (10, 126, and 256 SE cells per pool of 10 eggs) were used to conduct 3 experiments. The 10-egg pools were homogenized by one of 4 homogenization methods - mechanical stomaching, electric blending, hand massaging, and hand stirring - for 30 seconds. The homogenized eggs were then incubated at 37°C, and SE colonies were enumerated after 24 and 48 hours of incubation. After 24 hours of incubation, no SE was recovered from egg samples from stomached or electrically blended pools inoculated with <10 cells, while levels of 106 CFU/ml were found for samples from whipped or hand-massaged pools inoculated with <10 cells. Similarly, after 24 hours of incubation, the numbers of SE cells recovered from hand-massaged or hand-stirred egg pools inoculated with 126 cells were significantly larger than the numbers recovered from stomached or electrically blended egg pools inoculated with 126 cells. The number of SE cells recovered from samples homogenized with a blender was still significantly smaller than the numbers recovered from samples homogenized by the other 3 methods when the inoculum level was increased to 256 CFU per pool. However, the SE count for all samples approached 9 log10 CFU/ml after 48 hours of incubation. It is concluded that the detection of small SE populations in shell egg samples could be improved with the use hand massaging and hand stirring for homogenization.
KW - eggs
KW - food contamination
KW - food processing
KW - food safety
KW - homogenization
KW - microbial contamination
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Processing Equipment and Technology (NN600)
KW - Eggs and Egg Products (QQ040)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033156548&site=ehost-live&scope=site
UR - email: kseo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preenrichment versus direct selective agar plating for the detection of Salmonella Enteritidis in shell eggs.
AU - Valentín-Bon, I. E.
AU - Brackett, R. E.
AU - Seo, K. H.
AU - Hammack, T. S.
AU - Andrews, W. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 9
SP - 1670
EP - 1674
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Valentín-Bon, I. E.: U.S. Food and Drug Administration/Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Food and Beverages, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20033156549. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Soyabeans
N2 - The relative effectiveness of 2 methods for the recovery of Salmonella Enteritidis (SE) from jumbo and medium shell eggs was compared. The first method used in the comparison consisted of a preenrichment of the sample, and the second method was developed by the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS). Three bulk lots of blended, pooled eggs, each containing 220 liquid whole eggs that were thoroughly mixed manually were artificially inoculated with different levels of SE cells between approximately 100 and 103 CFU/ml. Twenty samples containing the contents of approximately 10 eggs each (by weight) were withdrawn from each of the inoculated bulk lots and incubated for 4 days at room temperature (ca. 23°C). For the APHIS method, each sample was cultured by direct plating onto brilliant green (BG), brilliant green with novobiocin (BGN), xylose lysine desoxycholate (XLD), and xylose lysine agar Tergitol 4 (XLT4) agars. For the preenrichment method, 25-g portions from each pool were enriched in modified tryptic soy broth with 30 mg/litre of FeSO4. After 24 hours of incubation, the preenrichments were subcultured to tetrathionate and Rappaport-Vassiliadis broths, and streaked to BG, BGN, bismuth sulfite, XLD, and XLT4 agar plates. SE isolates were confirmed biochemically and serologically. In all of the experiments, the preenrichment method recovered significantly more SE isolates (P<0.05) of all the phage types and inoculum levels than did the APHIS method. From a total of 539 jumbo egg test portions analysed, 381 (71%) were SE-positive by the preenrichment method and 232 (43%) were positive by the APHIS method. From a total of 360 medium egg test portions analysed, 223 (62%) were SE-positive by the preenrichment method and 174 (48%) were positive by the APHIS method. The preenrichment method provided greater sensitivity for the isolation of SE in contaminated egg slurries than did the APHIS method.
KW - detection
KW - eggs
KW - enrichment
KW - food contamination
KW - food safety
KW - microbial contamination
KW - microbiological techniques
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033156549&site=ehost-live&scope=site
UR - email: ivalenti@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sensitivity of Vibrio species in phosphate-buffered saline and in oysters to high-pressure processing.
AU - Cook, D. W.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003///
VL - 66
IS - 12
SP - 2276
EP - 2282
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cook, D. W.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033211767. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Tropical Diseases
N2 - Multiple strains of Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio cholerae non-O1 were tested in phosphate-buffered saline for their sensitivity to high-pressure processing (HPP). Variability in sensitivity among strains was observed for all species; this variability decreased at higher pressures. V. vulnificus was the species that was most sensitive to treatment at 200 MPa (decimal reduction time (D)=26 seconds), and V. cholerae was the species that was most resistant to treatment at 200 MPa (D=149 seconds). The O3:K6 serotype of V. parahaemolyticus was more resistant to pressure than other serotypes of V. parahaemolyticus were. The results of studies involving V. vulnificus naturally occurring in oysters revealed that a pressure treatment of 250 MPa for 120 seconds achieved a >5-log reduction in the levels of this bacterium. V. parahaemolyticus serotype O3:K6 in oysters required a pressure of 300 MPa for 180 seconds for a comparable 5-log reduction. When properly applied, HPP can be effective in improving the safety of shellfish with respect to Vibrio spp.
KW - decontamination
KW - food contamination
KW - food processing
KW - food safety
KW - microbial contamination
KW - oysters
KW - pressure treatment
KW - resistance
KW - Vibrio
KW - Vibrio cholerae
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Vibrio
KW - bacterium
KW - food contaminants
KW - Aquatic Produce (QQ060)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033211767&site=ehost-live&scope=site
UR - email: docjoc@cableone.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Behavioral counseling in primary care to promote a healthy diet: recommendations and rationale.
JO - American Family Physician
JF - American Family Physician
Y1 - 2003///
VL - 67
IS - 12
SP - 2573
EP - 2576
CY - Leawood; USA
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 6010 Executive Blvd., Suite 300, Rockville, MD 20852, USA.
N1 - Accession Number: 20043035726. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - This article summarizes the current US Preventive Services Task Force (USPSTF) recommendations on behavioural dietary counselling to promote a healthy diet in primary care patients and the supporting scientific evidence, and it updates the 1996 recommendations contained in the Guide to Clinical Preventive Services, second edition. The explanations of the ratings and strength of overall evidence are tabulated.
KW - behaviour
KW - behaviour modification
KW - counselling
KW - diet counseling
KW - diets
KW - guidelines
KW - primary health care
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - behavior modification
KW - counseling
KW - recommendations
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043035726&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, Western Kenya.
AU - Zucker, J. R.
AU - Ruebush, T. K., II
AU - Obonyo, C.
AU - Otieno, J.
AU - Campbell, C. C.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2003///
VL - 68
IS - 4
SP - 386
EP - 390
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Zucker, J. R.: Malaria Section, Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Atlanta, GA 34031, USA.
N1 - Accession Number: 20043121768. Publication Type: Journal Article. Language: English. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Tropical Diseases; Protozoology; Medical & Veterinary Entomology
N2 - In spite of increasing resistance, chloroquine remains the primary drug for treatment of malaria in most sub-Saharan African countries. We evaluated the effect of drug treatment policy on the case-fatality rates of children, adjusting for differing distributions of malaria and severe anemia. In 1991, 63% of children were treated with chloroquine while the remaining 37% were treated with a regimen that would eliminate and clear parasitemia. Case-fatality rates were 13% and 4.1%, respectively; the proportion of deaths attributable to chloroquine treatment was 69%. The trend in case-fatality rates for malaria decreased as an increasing proportion of children received an effective treatment regimen; adjusted malaria case-fatality rates were 5.1%, 3.6%, and 3.3% in 1992, 1993, and 1994, respectively, when 85% of children in 1992 and 97% of children in 1993-1994 received effective therapy. These 4 years of data provide strong evidence that continued use of chloroquine in areas with resistance is contributing to excess Plasmodium falciparum-related deaths.
KW - children
KW - chloroquine
KW - drug resistance
KW - epidemiology
KW - human diseases
KW - malaria
KW - mortality
KW - Kenya
KW - man
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - death rate
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043121768&site=ehost-live&scope=site
UR - http://www.ajtmh.org/cgi/content/abstract/68/4/386
UR - email: jzucker@health.nyc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal abundance of total and pathogenic Vibrio parahaemolyticus in Alabama oysters.
AU - DePaola, A.
AU - Nordstrom, J. L.
AU - Bowers, J. C.
AU - Wells, J. G.
AU - Cook, D. W.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2003///
VL - 69
IS - 3
SP - 1521
EP - 1526
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - DePaola, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033052818. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Animal Breeding; Human Nutrition
N2 - Recent Vibrio parahaemolyticus outbreaks associated with consumption of raw shellfish in the United States focused attention on the occurrence of this organism in shellfish. From March 1999 through September 2000, paired oyster samples were collected biweekly from two shellfish-growing areas in Mobile Bay, Ala. The presence and densities of V. parahaemolyticus were determined by using DNA probes targeting the thermolabile hemolysin (tlh) and thermostable direct hemolysin (tdh) genes for confirmation of total and pathogenic V. parahaemolyticus, respectively. V. parahaemolyticus was detected in all samples with densities ranging from <10 to 12 000 g-1. Higher V. parahaemolyticus densities were associated with higher water temperatures. Pathogenic strains were detected in 34 (21.8%) of 156 samples by direct plating or enrichment. Forty-six of 6 018 and 31 of 6 992 V. parahaemolyticus isolates from enrichments and direct plates, respectively, hybridized with the tdh probe. There was an apparent inverse relationship between water temperature and the prevalence of pathogenic strains. Pathogenic strains were of diverse serotypes, and 97% produced urease and possessed a tdh-related hemolysin (trh) gene. The O3:K6 serotype associated with pandemic spread and recent outbreaks in the United States was not detected. The efficient screening of numerous isolates by colony lift and DNA probe procedures may account for the higher prevalence of samples with tdh+V. parahaemolyticus than previously reported.
KW - epidemics
KW - epidemiology
KW - outbreaks
KW - oysters
KW - raw foods
KW - seasonal abundance
KW - Alabama
KW - USA
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - bacterium
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033052818&site=ehost-live&scope=site
UR - email: adepaola@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular, serological, and virulence characteristics of Vibrio parahaemolyticus isolated from environmental, food, and clinical sources in North America and Asia.
AU - DePaola, A.
AU - Ulaszek, J.
AU - Kaysner, C. A.
AU - Tenge, B. J.
AU - Nordstrom, J. L.
AU - Wells, J.
AU - Puhr, N.
AU - Gendel, S. M.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2003///
VL - 69
IS - 7
SP - 3999
EP - 4005
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - DePaola, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033126838. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9002-13-5. Subject Subsets: Public Health
N2 - Potential virulence attributes, serotypes, and ribotypes were determined for 178 pathogenic Vibrio parahaemolyticus isolates from clinical, environmental, and food sources on the Pacific, Atlantic, and Gulf Coasts of the United States and from clinical sources in Asia. The food and environmental isolates were generally from oysters, and they were defined as being pathogenic by using DNA probes to detect the presence of the thermostable direct hemolysin (tdh) gene. The clinical isolates from the United States were generally associated with oyster consumption, and most were obtained from outbreaks in Washington, Texas, and New York. Multiplex PCR was used to confirm the species identification and the presence of tdh and to test for the tdh-related hemolysin trh. Most of the environmental, food, and clinical isolates from the United States were positive for tdh, trh, and urease production. Outbreak-associated isolates from Texas, New York, and Asia were predominantly serotype O3:K6 and possessed only tdh. A total of 27 serotypes and 28 ribogroups were identified among the isolates, but the patterns of strain distribution differed between the serotypes and ribogroups. All but one of the O3:K6 isolates from Texas were in a different ribogroup from the O3:K6 isolates from New York or Asia. The O3:K6 serotype was not detected in any of the environmental and food isolates from the United States, and none of the food or environmental isolates belonged to any of the three ribogroups that contained all of the O3:K6 and related clinical isolates. The combination of serotyping and ribotyping showed that the Pacific Coast V. parahaemolyticus population appeared to be distinct from that of either the Atlantic Coast or Gulf Coast. The fact that certain serotypes and ribotypes contained both clinical and environmental isolates while many others contained only environmental isolates implies that certain serotypes or ribotypes are more relevant for human disease.
KW - bacterial diseases
KW - environment
KW - food contamination
KW - foodborne diseases
KW - genes
KW - genotypes
KW - haemolysins
KW - human diseases
KW - molecular epidemiology
KW - outbreaks
KW - oysters
KW - seafoods
KW - serotypes
KW - strains
KW - urease
KW - virulence
KW - Asia
KW - New York
KW - Texas
KW - USA
KW - Washington
KW - man
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - hemolysins
KW - ribotypes
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033126838&site=ehost-live&scope=site
UR - email: adepaola@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of Vibrio vulnificus from market oysters and septicemia cases for virulence markers.
AU - DePaola, A.
AU - Nordstrom, J. L.
AU - Dalsgaard, A.
AU - Forslund, A.
AU - Oliver, J.
AU - Bates, T.
AU - Bourdage, K. L.
AU - Gulig, P. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2003///
VL - 69
IS - 7
SP - 4006
EP - 4011
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - DePaola, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20033126839. Publication Type: Journal Article. Language: English. Number of References: 23 ref.
N2 - Representative encapsulated strains of Vibrio vulnificus from market oysters and oyster-associated primary septicemia cases (25 isolates each) were tested in a blinded fashion for potential virulence markers that may distinguish strains from these two sources. These isolates were analyzed for plasmid content, for the presence of a 460-bp amplicon by randomly amplified polymorphic DNA PCR, and for virulence in subcutaneously (s.c.) inoculated, iron-dextran-treated mice. Similar percentages of market oyster and clinical isolates possessed detectable plasmids (24 and 36%, respectively), produced the 460-bp amplicon (45 and 50%, respectively), and were judged to be virulent in the mouse s.c. inoculation-iron-dextran model (88% for each). Therefore, it appears that nearly all V. vulnificus strains in oysters are virulent and that genetic tests for plasmids and specific PCR size amplicons cannot distinguish between fully virulent and less virulent strains or between clinical and environmental isolates. The inability of these methods to distinguish food and clinical V. vulnificus isolates demonstrates the need for alternative subtyping approaches and virulence assays.
KW - bacterial diseases
KW - disease models
KW - experimental infections
KW - food contamination
KW - foodborne diseases
KW - genetic analysis
KW - human diseases
KW - laboratory animals
KW - molecular genetics
KW - nucleotide sequences
KW - oysters
KW - plasmids
KW - seafoods
KW - septicaemia
KW - shellfish
KW - strains
KW - virulence
KW - virulence factors
KW - USA
KW - man
KW - mice
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Muridae
KW - rodents
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - biochemical genetics
KW - blood poisoning
KW - DNA sequences
KW - food contaminants
KW - septicemia
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033126839&site=ehost-live&scope=site
UR - email: adepaola@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Targeting single-nucleotide polymorphisms in the 18S rRNA gene to differentiate Cyclospora species from Eimeria species by multiplex PCR.
AU - Orlandi, P. A.
AU - Carter, L.
AU - Brinker, A. M.
AU - Silva, A. J. da
AU - Chu, D. M.
AU - Lampel, K. A.
AU - Monday, S. R.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2003///
VL - 69
IS - 8
SP - 4806
EP - 4813
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Orlandi, P. A.: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20033156797. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health; Protozoology
N2 - Cyclospora cayetanensis is a coccidian parasite that causes protracted diarrheal illness in humans. C. cayetanensis is the only species of this genus thus far associated with human illness, although Cyclospora species from other primates have been named. The current method to detect the parasite uses a nested PCR assay to amplify a 294-bp region of the small subunit rRNA gene, followed by restriction fragment length polymorphism (RFLP) or DNA sequence analysis. Since the amplicons generated from C. cayetanensis and Eimeria species are the same size, the latter step is required to distinguish between these different species. The current PCR-RFLP protocol, however, cannot distinguish between C. cayetanensis and these new isolates. The differential identification of such pathogenic and nonpathogenic parasites is essential in assessing the risks to human health from microorganisms that may be potential contaminants in food and water sources. Therefore, to expand the utility of PCR to detect and identify these parasites in a multiplex assay, a series of genus- and species-specific forward primers were designed that are able to distinguish sites of limited sequence heterogeneity in the target gene. The most effective of these unique primers were those that identified single-nucleotide polymorphisms (SNPs) at the 3′ end of the primer. Under more stringent annealing and elongation conditions, these SNP primers were able to differentiate between C. cayetanensis, nonhuman primate species of Cyclospora, and Eimeria species. As a diagnostic tool, the SNP PCR protocol described here presents a more rapid and sensitive alternative to the currently available PCR-RFLP detection method. In addition, the specificity of these diagnostic primers removes the uncertainty that can be associated with analyses of foods or environmental sources suspected of harboring potential human parasitic pathogens.
KW - diagnosis
KW - differentiation
KW - genes
KW - human diseases
KW - polymerase chain reaction
KW - protozoal infections
KW - ribosomal RNA
KW - Cyclospora cayetanensis
KW - Eimeria
KW - man
KW - Cyclospora
KW - Eimeriidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - PCR
KW - protozoal diseases
KW - rRNA
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033156797&site=ehost-live&scope=site
UR - email: Porlandi@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular surveillance of enterovirus and Norwalk-like virus in oysters relocated to a municipal-sewage-impacted Gulf estuary.
AU - Shieh, Y. C.
AU - Baric, R. S.
AU - Woods, J. W.
AU - Calci, K. R.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2003///
VL - 69
IS - 12
SP - 7130
EP - 7136
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Shieh, Y. C.: Food and Drug Administration Gulf Coast Seafood Laboratory, P. O. Box 158, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20043004364. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Soils & Fertilizers
N2 - An 18-month survey was conducted to examine the prevalence of enteric viruses and their relationship to indicators in environmentally polluted shellfish. Groups of oysters, one group per 4 weeks, were relocated to a coastal water area in the Gulf of Mexico that is impacted by municipal sewage and were analysed for enteroviruses, Norwalk-like viruses (NLV), and indicator microorganisms (faecal coliform, Escherichia coli, and male-specific coliphages). The levels of indicator microorganisms were consistent with the expected continuous pollution of the area. Fourteen of the 18 oyster samples were found by reverse transcription (RT)-PCR to harbour NLV and/or enterovirus sequences. Of the four virus-negative oysters, three had exposure to water temperatures of >29°C. Concomitant with these findings, two of these four oysters also accumulated the lowest levels of coliphages. PCR primers targeting pan-enteroviruses and the NLV 95/96-US common subset were utilized; NLV sequences were detected more frequently than those of enteroviruses. Within the 12-month sampling period, NLV and enterovirus sequences were detected in 58 and 42%, respectively, of the oysters (67% of the oysters tested were positive for at least one virus) from a prohibited shellfish-growing area approximately 30 m away from a sewage discharge site. Eight (4.6%) of the 175 NLV capsid nucleotide sequences were heterogeneous among the clones derived from naturally polluted oysters. Overall, enteric viral sequences were found in the contaminated oysters throughout all seasons except hot summer, with a higher prevalence of NLV than enterovirus. Although a high percentage of the oysters harbored enteric viruses, the virus levels were usually less than or equal to 2 logs of RT-PCR-detectable units per gram of oyster meat.
KW - estuaries
KW - faecal coliforms
KW - food contamination
KW - food safety
KW - microbial contamination
KW - oysters
KW - sewage effluent
KW - surveillance
KW - water pollution
KW - Enterovirus
KW - Escherichia coli
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Norovirus
KW - Caliciviridae
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - food contaminants
KW - Norwalk-like virus
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043004364&site=ehost-live&scope=site
UR - email: yshieh@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular and serological aspects of HBsAg-negative hepatitis B virus infections in North America.
AU - Hsia, C. C.
AU - Scudamore, C. H.
AU - Bisceglie, A. M. di
AU - Tabor, E.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2003///
VL - 70
IS - 1
SP - 20
EP - 26
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Hsia, C. C.: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20033063968. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - A few hepatitis B virus (HBV) infections are characterized by the presence of HBV DNA in serum or liver tissue, or both, in the absence of detectable hepatitis B surface antigen (HBsAg) in serum. However, such infections have rarely been described previously in North American patients. In the present study, 31 hepatocellular carcinoma (HCC) patients from the United States and Canada who had no detectable HBsAg in their serum were studied. In these 31 HBsAg-negative HCC patients, HBV DNA was detected in HCC and/or in adjacent nontumorous liver tissue using nested polymerase chain reaction (PCR) in 5/9 (56%) patients from the United States and in 12/22 (55%) from Canada. The 17 HBV DNA-positive/HBsAg-negative patients from the United States and Canada included 9 without any serological markers for HBV and 8 with detectable antibodies to hepatitis B core antigen. In these patients, HBV genotype C was the most prevalent genotype (11/17; 64%). HBV genotypes have not been previously reported in HCC patients from North America. Replicative intermediate forms of HBV (covalently closed circular HBV DNA) were detected in 2/17 (12%) HBV DNA-positive/HBsAg-negative patients, indicating that at least two of these patients had actively replicating HBV infections. The use of tests to detect HBV DNA permitted the identification of HBV infections in HBsAg-negative HCC patients from North America. Among these patients, those with antibody to hepatitis C virus (HCV) would otherwise have been designated "HCV-associated HCCs" based on serological tests alone. These findings provide a new perspective on determining the possible viral etiologies of HCCs in North America.
KW - genotypes
KW - hepatitis B
KW - hepatoma
KW - human diseases
KW - liver
KW - liver diseases
KW - neoplasms
KW - Canada
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033063968&site=ehost-live&scope=site
UR - email: tabor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic variability among serotype G6 human rotaviruses: identification of a novel lineage isolated in Hungary.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Griffin, D. D.
AU - Holmes, J. L.
AU - Glass, R. I.
AU - Szücs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2003///
VL - 71
IS - 1
SP - 124
EP - 134
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20033134292. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - Rotavirus serotype G6 has been demonstrated to be a rare cause of gastroenteritis in man. To date, only a few well characterized strains have been described from Italy, Australia, and the United States. Nucleotide sequencing of G6 VP7 genes shows that these strains belong to two distinct G6 lineages, one for strains of serotype P11[14],G6 (PA169-like strains) and one for strains of serotype P3[9],G6 (PA151-like strains). In this study, we sequenced the VP7 genes and VP8* gene fragments of human rotavirus G6 strains detected in Hungary. Phylogenetic analysis demonstrated that the VP7 genes of Hungarian G6 strains fell into three lineages, represented by a single PA169-like strain, three PA151-like strains, and two novel G6 strains, respectively. The amino acid sequence identity of VP7 was 97.2-100% within each lineage and 92-93.9% between any two lineages. The sequence analysis of VP8* revealed that the single PA169-like Hungarian G6 strain belonged to genotype P[14] and was phylogenetically closely related to P11[14],G6 strains characterized previously. In contrast, the VP8* of PA151-like Hungarian G6 strains clustered in accordance with their VP7 genes representing genetically distinguishable variants of genotype P[9]. This finding raises the possibility that Hungarian genotype P[9],G6 strains might have been generated through independent reassortment events. Serotype G6-specific primers for each human G6 lineage were also developed. The use of these primers in reverse-transcription polymerase chain reaction genotyping may help determine the epidemiological role of G6 strains in humans.
KW - aetiology
KW - amino acid sequences
KW - epidemiology
KW - gastroenteritis
KW - genes
KW - genetic variation
KW - genetics
KW - genotypes
KW - human diseases
KW - nucleotide sequences
KW - phylogenetics
KW - serotypes
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - causal agents
KW - DNA sequences
KW - etiology
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - protein sequences
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033134292&site=ehost-live&scope=site
UR - email: gszucs@main.antszbar.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation.
AU - Bertholet, S.
AU - Dickensheets, H. L.
AU - Sheikh, F.
AU - Gam, A. A.
AU - Donnelly, R. P.
AU - Kenney, R. T.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2003///
VL - 71
IS - 4
SP - 2095
EP - 2101
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Bertholet, S.: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033065075. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1404-26-8, 308079-78-9. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Public Health
N2 - Leishmania donovani protozoan parasites, the causative agent of visceral leishmaniasis, establish an infection partly by interfering with cytokine signaling in the host macrophages. Therefore, we investigated the expression of the suppressor of cytokine signaling (SOCS) genes in human macrophages infected with L. donovani. The expression of SOCS3 mRNA was induced transiently after exposure to live or heat-killed parasites, but not purified lipophosphoglycan, while that of other SOCS genes remained unchanged. SOCS3 gene expression was not dependent on phagocytosis or on cytokines released by L. donovani-infected macrophages, such as interleukin-1β or tumor necrosis factor alpha. In addition, Leishmania used a different signaling pathway(s) than bacterial lipopolysaccharide to induce SOCS3 mRNA, as indicated by the kinetics of induction and sensitivity to polymyxin B inhibition. Finally, phosphorylation of the STAT1 transcription factor was significantly reduced in L. donovani-infected macrophages and required de novo transcription. The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganisms may suppress macrophage activation and interfere with the host immune response.
KW - aetiology
KW - antibacterial agents
KW - cytokines
KW - epidemiology
KW - gene expression
KW - genes
KW - human diseases
KW - immune response
KW - interleukin 1
KW - interleukins
KW - lipopolysaccharides
KW - macrophage activation
KW - macrophages
KW - messenger RNA
KW - phagocytosis
KW - phosphorylation
KW - polymyxin B
KW - protozoal infections
KW - transcription factors
KW - tumour necrosis factor
KW - visceral leishmaniasis
KW - Leishmania
KW - Leishmania donovani
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Leishmania
KW - cachectin
KW - cachexin
KW - causal agents
KW - etiology
KW - immunity reactions
KW - immunological reactions
KW - mRNA
KW - protozoal diseases
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033065075&site=ehost-live&scope=site
UR - email: rkenney@iomai.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Increased density of human immunodeficiency virus type 1 coreceptors CCR5 and CXCR4 on the surfaces of CD4+ T cells and monocytes of patients with Schistosoma mansoni infection.
AU - Secor, W. E.
AU - Amil Shah
AU - Mwinzi, P. M. N.
AU - Ndenga, B. A.
AU - Watta, C. O.
AU - Karanja, D. M. S.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2003///
VL - 71
IS - 11
SP - 6668
EP - 6671
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Secor, W. E.: Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20033190387. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Tropical Diseases; Helminthology
N2 - Distribution of chemokine receptors CCR5 and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4+ T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients.
KW - anthelmintics
KW - biochemical receptors
KW - CD4+ lymphocytes
KW - chemokines
KW - concurrent infections
KW - drug therapy
KW - human diseases
KW - monocytes
KW - schistosomiasis
KW - Kenya
KW - Human immunodeficiency virus 1
KW - man
KW - Schistosoma mansoni
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - bilharzia
KW - bilharziasis
KW - CD4+ cells
KW - chemotherapy
KW - human immunodeficiency virus type 1
KW - schistosomosis
KW - Strigeida
KW - T4 lymphocytes
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033190387&site=ehost-live&scope=site
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary exposure to genistein increases vasopressin but does not alter β-endorphin in the rat hypothalamus.
AU - Scallet, A. C.
AU - Wofford, M.
AU - Meredith, J. C.
AU - Allaben, W. T.
AU - Ferguson, S. A.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003///
VL - 72
IS - 2
SP - 296
EP - 300
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Scallet, A. C.: Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033068592. Publication Type: Journal Article. Language: English. Registry Number: 50-28-2, 446-72-0, 11000-17-2. Subject Subsets: Dairy Science; Human Nutrition; Soyabeans
N2 - Genistein is a plant-derived estrogenic isoflavone commonly found in soy-based products such as soymilk and soy-based dietary supplements for treating menopausal symptoms, for example. Vasopressin is a neurosecretory nonapeptide synthesized primarily in neurons of the hypothalamus and secreted into the bloodstream from the posterior lobe of the pituitary. The endogenous opiate peptide β-endorphin is synthesized both in neurons of the hypothalamus and in pituitary cells, primarily of the neurointermediate lobe. It has been reported that exposure to 17β-estradiol or diethylstilbesterol increased the vasopressin content of the hypothalamus, and that estradiol valerate selectively damages hypothalamic β-endorphin-containing neurons. Since little was known of the potential effects of estrogenic endocrine-disruptor compounds on hypothalamic neuropeptides, we fed Sprague-Dawley fetuses from day 7 in utero until sacrifice at postnatal day 77, with either a control diet (<1 ppm) or an experimental diet containing 25, 250, or 1250 ppm of genistein. We then conducted ELISA assays for hypothalamic content of both β-endorphin and vasopressin immunoreactivity. Whereas there were no statistically reliable effects of dietary genistein on hypothalamic β-endorphin content, vasopressin levels were significantly elevated in the 1250-ppm genistein group (p<0.05). Elevated vasopressin levels may be associated with fluid balance, altered blood pressure, and cardiovascular effects. These data are consistent with the known actions of estradiol and may serve to explain our finding in a previous study that estrogenic endocrine-disruptors such as genistein increased sodium preference in rats exposed through their diet.
KW - animal models
KW - blood pressure
KW - endorphins
KW - equilibrium
KW - estradiol
KW - genistein
KW - hypothalamus
KW - pituitary
KW - soya milk
KW - soyabean products
KW - vasopressin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antidiuretic hormone
KW - biochanin A
KW - hypophysis
KW - oestradiol
KW - pitressin
KW - pituitary gland
KW - soy milk
KW - soyabean milk
KW - soybean products
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033068592&site=ehost-live&scope=site
UR - http://toxsci.oupjournals.org/cgi/content/abstract/72/2/296
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of intermittent exposure to aflatoxin B1 on DNA and RNA adduct formation in rat liver: dose-response and temporal patterns.
AU - Sotomayor, R. E.
AU - Washington, M.
AU - Linh Nguyen
AU - Rahma Nyang'anyi
AU - Hinton, D. M.
AU - Chou, M.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003///
VL - 73
IS - 2
SP - 329
EP - 338
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Sotomayor, R. E.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, University of Maryland, College Park, MD 20742, USA.
N1 - Accession Number: 20033115600. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Medical & Veterinary Mycology
N2 - We studied the effects of intermittent exposure to aflatoxin B1 (AFB1) on hepatic DNA and RNA adduct formation. Fisher-344 male rats were fed 0.01, 0.04, 0.4, or 1.6 ppm of AFB1 intermittently for 8, 12, 16, and 20 weeks, alternating with 4 weeks of dosing and 4 weeks of rest. Other groups of rats were fed 1.6 ppm of AFB1 continuously for 4, 8, 12, and 16 weeks. Control rats received AFB1-free NIH-31 meal diet. AFB1-DNA and -RNA adducts were measured by HPLC with fluorescence detection. The data are presented as total DNA or RNA adducts. The DNA and RNA adduct levels increased or decreased depending on the cycles of dosing and rest. Rats removed from treatment 1 month after 1 or 2 dosing cycles (8 and 16 weeks of intermittent exposure) showed approximately a twofold decrease in DNA adduct levels and a two- to elevenfold decrease in RNA adduct levels compared with rats euthanized immediately after the last dosing cycle (12 and 20 weeks of intermittent exposure). Our data indicate that DNA and RNA adducts increased linearly, from 0.01 ppm to 1.6 ppm of AFB1 after 12 and 20 weeks of intermittent treatment. A linear dose response was also apparent for DNA but not for RNA adducts after 8 and 16 weeks of treatment. As biomarkers of exposure, AFB1-RNA adducts were three to nine times more sensitive than AFB1-DNA adducts but showed greater variability. These results suggest that binding of AFB1 to hepatic DNA is a linear function of the dose, regardless of the way this is administered. The dose-response relationship for RNA adducts depends on the length of the no-dosing cycles and on the turnover rate of RNA.
KW - aflatoxins
KW - DNA
KW - food contamination
KW - genotoxicity
KW - laboratory animals
KW - liver
KW - mycotoxins
KW - RNA
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - food contaminants
KW - fungal toxins
KW - ribonucleic acid
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033115600&site=ehost-live&scope=site
UR - http://toxsci.oupjournals.org/cgi/content/abstract/73/2/329
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunotoxicity of aflatoxin B1 in rats: effects on lymphocytes and the inflammatory response in a chronic intermittent dosing study.
AU - Hinton, D. M.
AU - Myers, M. J.
AU - Raybourne, R. A.
AU - Francke-Carroll, S.
AU - Sotomayor, R. E.
AU - Shaddock, J.
AU - Warbritton, A.
AU - Chou, M. W.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003///
VL - 73
IS - 2
SP - 362
EP - 377
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Hinton, D. M.: Center for Food Safety and Applied Nutrition, United States Food and Drug Association, Laurel, MD 20708, USA.
N1 - Accession Number: 20033115602. Publication Type: Journal Article. Language: English. Registry Number: 102524-44-7, 85898-30-2. Subject Subsets: Medical & Veterinary Mycology
N2 - We investigated the effects of aflatoxin B1 (AFB1) on isolated splenic lymphocytes and the histo-morphologic changes in the spleens and liver of Fisher-344 male rats. Weaned animals were fed chow diets that contained 0, 0.01, 0.04, 0.4, or 1.6 ppm AFB1, using an intermittent dosing regimen (4 weeks on and 4 weeks off AFB1), for 40 weeks. An additional group of animals was fed the 1.6 ppm AFB1 diet continuously. The intermittent dosing regimen was designed to evaluate effects of cumulative dose and exposure for risk assessment comparisons. The percentages of T and B cells were affected as shown by flow cytometric analysis after the dosing cycles. The observed changes appeared to reverse or compensate to some extent after the off cycles. Lymphocytes were stimulated in culture for analysis of the production of IL-2, IL-1, and IL-6. Significantly increased production of IL-1 and IL-6 was seen in the second dosing cycle (12 weeks) and the second "off" cycle (16 weeks) at the higher doses. Inflammatory infiltrates were seen in the liver after eight weeks of continuous and intermittent dosing and were increased in size and number at 12 weeks in both 1.6 ppm dose groups correlating with the peak production of IL-1 and IL-6. We concluded that AFB1 effects on the immune system can be either stimulatory or suppressive dependent on a critical exposure window of dose and time. Immune cells in spleen such as T-lymphocytes and macrophages, both important mediators of inflammatory responses to tissue damage, were affected differently in the continuous and intermittent exposures to AFB1.
KW - aflatoxins
KW - B lymphocytes
KW - food contamination
KW - immune response
KW - inflammation
KW - interleukin 1
KW - interleukin 2
KW - interleukin 6
KW - laboratory animals
KW - liver
KW - mycotoxins
KW - spleen
KW - T lymphocytes
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - B cells
KW - food contaminants
KW - fungal toxins
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033115602&site=ehost-live&scope=site
UR - http://toxsci.oupjournals.org/cgi/content/abstract/73/2/362
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dermal exposure to 3-amino-5-mercapto-1,2,4-triazole (AMT) induces sensitization and airway hyperreactivity in BALB/c mice.
AU - Klink, K. J.
AU - Meade, B. J.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003///
VL - 75
IS - 1
SP - 89
EP - 98
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Klink, K. J.: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20033175910. Publication Type: Journal Article. Language: English. Registry Number: 37341-29-0. Subject Subsets: Weeds; Veterinary Science; Veterinary Science
N2 - A cluster of occupational asthma (OA) cases associated with occupational exposure to 3-amino-5-mercapto-1,2,4-triazole (AMT) and N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide (DE498) in a herbicide producing plant was previously reported by the National Institute for Occupational Safety and Health. Due to the limited toxicological data available for these chemicals, murine studies were undertaken to evaluate the toxicity and sensitization potential of these two agents. No signs of systemic toxicity as evaluated by body and selected organ weights or irritancy were observed following dermal exposure to concentrations up to 25% (w/v) AMT in BALB/c mice. DE498 tested negative for sensitization potential in both the TOPKAT QSAR model and in vivo in the Local Lymph Node Assay (LLNA), while AMT tested positive in both TOPKAT QSAR and the LLNA. Evaluation of the potential for AMT to induce contact hypersensitivity using the MEST yielded negative results. Cytokine evaluation and phenotypic analysis of draining lymph node (DLN) cells demonstrated an increase in IL-4 and IgE+B220+cells 4 and 10 days post initial exposure, respectively. Following dermal exposure 7 days a week for 35 days, animals exposed to up to 25% AMT demonstrated a dose-dependent elevation in total serum IgE and an increase in airway hyperreactivity upon methacholine challenge. Following intratracheal challenge with AMT, pulmonary histopathology revealed a dose-dependent suppurative and histiocytic alveolitis in these animals. These studies indicate that DE498 does not induce sensitization following dermal exposure; however, AMT was identified as a sensitizer with the potential to induce airway hyperreactivity.
KW - asthma
KW - cytokines
KW - herbicides
KW - hypersensitivity
KW - IgE
KW - lymph nodes
KW - occupational hazards
KW - organs
KW - poisonous plants
KW - skin
KW - toxic substances
KW - toxicity
KW - toxicology
KW - mice
KW - plants
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 3-amino-5-mercapto-1,2,4-triazole
KW - allergic responses
KW - dermis
KW - hypersensitiveness
KW - N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimi
KW - poisons
KW - reagin
KW - reaginic antibodies
KW - toxic plants
KW - weedicides
KW - weedkillers
KW - Weeds and Noxious Plants (FF500)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033175910&site=ehost-live&scope=site
UR - http://toxsci.oupjournals.org/cgi/content/abstract/75/1/89
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development.
AU - Huang, C. Y. H.
AU - Butrapet, S.
AU - Tsuchiya, K. R.
AU - Bhamarapravati, N.
AU - Gubler, D. J.
AU - Kinney, R. M.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003///
VL - 77
IS - 21
SP - 11436
EP - 11447
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Huang, C. Y. H.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20033196126. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Tropical Diseases; Agricultural Biotechnology; Medical & Veterinary Entomology
N2 - Attenuation markers of the candidate dengue 2 (D2) PDK-53 vaccine virus are encoded by mutations that reside outside of the structural gene region of the genome. We engineered nine dengue virus chimeras containing the premembrane (prM) and envelope (E) genes of wild-type D1 16007, D3 16562, or D4 1036 virus within the genetic backgrounds of wild-type D2 16681 virus and the two genetic variants (PDK53-E and PDK53-V) of the D2 PDK-53 vaccine virus. Expression of the heterologous prM-E genes in the genetic backgrounds of the two D2 PDK-53 variants, but not that of wild-type D2 16681 virus, resulted in chimeric viruses that retained PDK-53 characteristic phenotypic markers of attenuation, including small plaque size and temperature sensitivity in LLC-MK2 cells, limited replication in C6/36 cells, and lack of neurovirulence in newborn ICR mice. Chimeric D2/1, D2/3, and D2/4 viruses replicated efficiently in Vero cells and were immunogenic in AG129 mice. Chimeric D2/1 viruses protected adult AG129 mice against lethal D1 virus challenge. Two tetravalent virus formulations, comprised of either PDK53-E- or PDK53-V-vectored viruses, elicited neutralizing antibody titers in mice against all four dengue serotypes. These antibody titers were similar to the titers elicited by monovalent immunizations, suggesting that viral interference did not occur in recipients of the tetravalent formulations. The results of this study demonstrate that the unique attenuation loci of D2 PDK-53 virus make it an attractive vector for the development of live attenuated flavivirus vaccines.
KW - animal models
KW - attenuation
KW - chimaeras
KW - DNA vaccines
KW - envelope proteins
KW - genes
KW - immunization
KW - mutations
KW - vaccine development
KW - virus neutralization
KW - dengue 2 virus
KW - mice
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chimeras
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033196126&site=ehost-live&scope=site
UR - email: chuang1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study.
AU - Dragunsky, E.
AU - Nomura, T.
AU - Karpinski, K.
AU - Furesz, J.
AU - Wood, D. J.
AU - Pervikov, Y.
AU - Abe, S.
AU - Kurata, T.
AU - Vanloocke, O.
AU - Karganova, G.
AU - Taffs, R.
AU - Heath, A.
AU - Ivshina, A.
AU - Levenbook, I.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2003///
VL - 81
IS - 4
SP - 251
EP - 260
CY - Geneva; Switzerland
PB - World Health Organization
SN - 0042-9686
AD - Dragunsky, E.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20033077252. Publication Type: Journal Article. Language: English. Language of Summary: Arabic; Spanish; French. Number of References: 25 ref. Subject Subsets: Agricultural Biotechnology
N2 - Objective: Extensive WHO collaborative studies were performed to evaluate the suitability of transgenic mice susceptible to poliovirus (TgPVR mice, strain 21, bred and provided by the Central Institute for Experimental Animals, Japan) as an alternative to monkeys in the neurovirulence test (NVT) of oral poliovirus vaccine (OPV). Methods: Nine laboratories participated in the collaborative study on testing neurovirulence of 94 preparations of OPV and vaccine derivatives of all three serotypes in TgPVR21 mice. Findings: Statistical analysis of the data demonstrated that the TgPVR21 mouse NVT was of comparable sensitivity and reproducibility to the conventional WHO NVT in simians. A statistical model for acceptance/rejection of OPV lots in the mouse test was developed, validated, and shown to be suitable for all three vaccine types. The assessment of the transgenic mouse NVT is based on clinical evaluation of paralyzed mice. Unlike the monkey NVT, histological examination of central nervous system tissue of each mouse offered no advantage over careful and detailed clinical observation. Conclusions: Based on data from the collaborative studies the WHO Expert Committee for Biological Standardization approved the mouse NVT as an alternative to the monkey test for all three OPV types and defined a standard implementation process for laboratories that wish to use the test. This represents the first successful introduction of transgenic animals into control of biologicals.
KW - animal models
KW - central nervous system
KW - genetically engineered organisms
KW - laboratories
KW - laboratory animals
KW - live vaccines
KW - transgenic animals
KW - virulence
KW - mice
KW - monkeys
KW - Poliovirus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Primates
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - attenuated vaccines
KW - CNS
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - human poliovirus
KW - neurovirulence
KW - oral poliovirus vaccine
KW - transgenic organisms
KW - Host Resistance and Immunity (HH600)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033077252&site=ehost-live&scope=site
UR - email: dragunsky@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial-resistant Salmonella serovars isolated from imported foods.
AU - Zhao, S. H.
AU - Datta, A. R.
AU - Ayers, S.
AU - Friedman, S.
AU - Walker, R. D.
AU - White, D. G.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2003///
VL - 84
IS - 1
SP - 87
EP - 92
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Zhao, S. H.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043126913. Publication Type: Journal Article. Language: English. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 56-75-7, 58001-44-8, 8064-90-2, 389-08-2, 723-46-6, 60-54-8, 64-75-5. Subject Subsets: Human Nutrition
N2 - A total of 187 Salmonella isolates representing 82 serotypes recovered from 4072 imported foods in the year 2000 by the U.S. Food and Drug Administration field laboratories were tested for their susceptibility to 17 antimicrobials of human and veterinary importance. Fifteen (8%) isolates were resistant to at least one antimicrobial, and five (2.7%) were resistant to three or more antimicrobials. Most of the isolates (n=9) exhibited resistance to tetracycline. Four isolates from catfish or tilapia from Taiwan or Thailand also demonstrated resistance to nalidixic acid. These nalidixic acid-resistant Salmonella isolates possessed a point mutation at the Ser83 or Asp87 position in DNA gryase, resulting in amino acid substitutions to phenylalanine, tyrosine, or asparagine. One Salmonella Derby isolated from frozen anchovies imported from Cambodia was resistant to six antimicrobials including ampicillin, amoxicillin/clavulanic acid, chloramphenicol, sulfamethoxazole, tetracycline, and trimethoprim/sulfamethoxazole. Of seven isolates displaying resistance to sulfonamides, only one S. Derby and one Salmonella Agona contained class 1 integrons that were further shown to possess the aadA and pse-1 genes conferring resistance to streptomycin and ampicillin, respectively. This study indicates that antimicrobial-resistant Salmonella are present in imported foods, primarily of seafood origin, and stresses the need for continued surveillance of foodborne zoonotic bacterial pathogens from imported foods entering the United States.
KW - amoxicillin
KW - ampicillin
KW - antibacterial agents
KW - chloramphenicol
KW - clavulanic acid
KW - co-trimoxazole
KW - drug resistance
KW - imports
KW - nalidixic acid
KW - seafoods
KW - sulfamethoxazole
KW - sulfonamides
KW - tetracycline
KW - Taiwan
KW - Thailand
KW - USA
KW - anchovies
KW - Ictalurus punctatus
KW - Salmonella
KW - Tilapia
KW - Engraulidae
KW - Clupeiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Cichlidae
KW - Perciformes
KW - APEC countries
KW - Developed Countries
KW - South East Asia
KW - Asia
KW - ASEAN Countries
KW - Developing Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - amoxycillin
KW - bacterium
KW - Formosa
KW - sulphamethoxazole
KW - sulphonamides
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043126913&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-47427ND-1&_user=10&_handle=B-WA-A-A-AE-MsSAYWW-UUA-AUEVZVBVCY-AUEWWWVWCY-CZUYEABCV-AE-U&_fmt=summary&_coverDate=07%2F15%2F2003&_rdoc=11&_orig=browse&_srch=%23toc%235061%232003%23999159998%23432906!&_cdi=5061&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3102b051271d3c63070b503a48ebb684
UR - email: szhao@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy of glutaraldehyde disinfectant against Cryptosporidium parvum in the presence of various organic soils.
AU - Wilson, J.
AU - Margolin, A. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 1
SP - 96
EP - 100
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Wilson, J.: U.S. Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St, Winchester, MA 01890-1152, USA.
N1 - Accession Number: 20033032068. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 111-30-8. Subject Subsets: Protozoology
N2 - The opportunistic protozoan Cryptosporidium parvum is highly resistant to disinfectants, including those specifically used for processing reused medical equipment in hospitals. C. parvum oocysts were dried onto glass and steel grooved penicylinders and challenged with 2.5% glutaraldehyde solution in the presence of 3 types of soil with exposures at 10 min, 90 min, and 10 h. The influence of organic soils on disinfection was measured with 5% fetal bovine serum (FBS), 10% FBS, and 5 mg mucin/ml. An in vitro excystation procedure and cell culture infection assay were used to determine survivability of oocysts after the germicide challenge. In the presence of organic soil, all oocysts removed from carriers excysted and infected cell monolayers after all germicide contact times. However, excystation was observed only from oocysts that received no protection from organic soil after 10 h exposure. In these samples, no infection was observed in the cell monolayers. The results of this research demonstrate the importance of thorough cleaning of medical equipment before disinfection.
KW - disinfectants
KW - disinfection
KW - glutaraldehyde
KW - oocysts
KW - organic soils
KW - potency
KW - Cryptosporidium parvum
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033032068&site=ehost-live&scope=site
UR - email: jwilson@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 1
SP - 129
EP - 138
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20033032057. Publication Type: Journal Article. Language: English. Number of References: 113 ref. Registry Number: 17924-92-4, 149-29-1, 518-75-2, 18172-33-3. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - A report by the Committee on Natural Toxins and Food Allergens of AOAC International is presented. The detection, analytical methods and incidence of contamination by aflatoxin M1, alternaria toxin, citrinin, cyclopiazonic acid, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes, zearalenone in food and food products are briefly discussed along with recommendations for future studies on these toxins.
KW - aflatoxins
KW - analytical methods
KW - citrinin
KW - cyclopiazonic acid
KW - ergot alkaloids
KW - food contamination
KW - food products
KW - foods
KW - fumonisins
KW - international organizations
KW - mycotoxicoses
KW - mycotoxins
KW - ochratoxins
KW - patulin
KW - trichothecenes
KW - zearalenone
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - analytical techniques
KW - ergot derivatives
KW - f-2 toxin
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - mycotoxin poisoning
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033032057&site=ehost-live&scope=site
UR - email: mtruckse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of phenolic compounds in dietary supplements and tea blends containing Echinacea by liquid chromatography with coulometric electrochemical detection.
AU - Luo, W. H.
AU - Ang, C. Y. W.
AU - Gehring, T. A.
AU - Heinze, T. M.
AU - Lin, L. J.
AU - Mattia, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 2
SP - 202
EP - 208
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Luo, W. H.: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Chemistry, 3900 NCTR Rd, HFT-230, Jefferson, AR 72079-9501, USA.
N1 - Accession Number: 20033069123. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants
N2 - Analytical methodologies with ultrasonic extraction and liquid chromatography (LC) were developed for the determination of phenolic compounds in dietary supplements containing Echinacea. The phenolic compounds determined by these methods included caftaric acid, chlorogenic acid, cynarin, echinacoside, and cichoric acid. Samples from tablets, capsules, and bags of tea blends were extracted by sonication for ≤30 min with methanol-water (60+40). The extracts were centrifuged and filtered, and the filtrates were diluted and analyzed by LC using a reversed-phase column and coulometric electrochemical (EC) detection. The mobile phase was acetonitrile-ammonium formate buffer, pH 3.5 (15.3+84.7) containing tetrabutyl ammonium hydrogen sulfate as an ion-pairing reagent. Extraction conditions (e.g., composition of the extraction solvent and sonication time) were optimized for different types of samples. Intra- and interday analytical variations were determined, and intraday analyses were performed by 2 independent analysts using 2 different LC systems. Results were generally comparable. The LC method with EC detection showed better sensitivity and selectivity when compared with LC with ultraviolet detection, although results were similar for the 2 methods for major compounds, i.e., caftaric acid, echinacoside, and cichoric acid. The identities of these major compounds found in samples were confirmed by LC/electrospray ionization mass spectrometry.
KW - chemical composition
KW - food composition
KW - food supplements
KW - phenolic compounds
KW - tea
KW - Camellia sinensis
KW - Echinacea
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Asteraceae
KW - Asterales
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033069123&site=ehost-live&scope=site
UR - email: cang@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of botulinal neurotoxins A, B, E, and F by amplified enzyme-linked immunosorbent assay: collaborative study.
AU - Ferreira, J. L.
AU - Maslanka, S.
AU - Johnson, E.
AU - Goodnough, M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 2
SP - 314
EP - 331
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Ferreira, J. L.: U.S. Food and Drug Administration, 60 8th St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20033069129. Publication Type: Journal Article. Language: English. Number of References: 7 ref.
N2 - An amplified enzyme-linked immunosorbent assay (amp-ELISA) was compared with the AOAC Official Method 977.26 for detection of Clostridium botulinum and its toxins in foods. Eleven laboratories participated and the results of 10 laboratories were used in the study. Two anaerobic culture media, tryptone peptone glucose yeast extract (TPGY) and cooked meat medium (CMM) were used to generate toxic samples with types A, B, E, and F botulinal strains. Nonbotulinal clostridia were also tested. The toxicity of each botulinal culture was determined by the AOAC method, and the cultures were then diluted, if necessary, to high (about 10 000 minimal lethal dose [MLD]/mL) and low (about 100 MLD/mL) test samples. The overall sensitivity of detection in TPGY and CMM cultures with the amp-ELISA was 94.7% at about 100 MLD/mL and 99.6% for samples with ≥10 000 MLD/mL toxicity. The amp-ELISA detection sensitivity for low toxin samples was 92.3% in TPGY and 99.4% in CMM. The false-positive rate ranged from 1.5% for type A to 28.6% for type F in TPGY, and from 2.4% for type A to 11.4% for type F in CMM. Most of the cross-reactivity was due to detection of other botulinal types, especially in high toxin samples. The amp-ELISA could be used to screen suspect cultures for botulinal toxins. Positive amp-ELISA samples would be confirmed by the AOAC reference method.
KW - bacterial toxins
KW - culture media
KW - ELISA
KW - food contamination
KW - meat products
KW - microbial contamination
KW - neurotoxins
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033069129&site=ehost-live&scope=site
UR - email: jferreir@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of sulfite in dried garlic by reversed-phase ion-pairing liquid chromatography with post-column detection.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 3
SP - 544
EP - 550
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Perfetti, G. A.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20033122628. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 50-00-0, 7647-01-0, 1310-58-3, 7446-09-5. Subject Subsets: Postharvest Research; Human Nutrition
N2 - A method was described for determining sulfite in dried garlic. Garlic was extracted with an HCl solution to inhibit the formation of allicin, which interfered with the determination of sulfite. After cleanup of the extract on a C18 solid-phase extraction column, sulfite was converted to hydroxymethylsulfonate (HMS) by adding formaldehyde and heating to 50°C. HMS was determined by reversed-phase ion-pairing liquid chromatography with post-column detection. The post-column reaction system consisted of the addition of KOH to convert HMS to sulfite ion, followed by the addition of 5,5′-dithiobis(2-nitrobenzoic acid) to produce 5-mercapto-2-nitrobenzoic acid which was detected spectrophotometrically at 450 nm. Background levels in unsulfited dried garlic equivalent to <20 ppm SO2 were found. Recoveries of HMS from spiked garlic averaged 94.8% with a coefficient of variation of 3.8%. Sulfite was found in 13 out of 21 samples of dried garlic produced in China, with sulfite ranging from 114 to 445 ppm. Sulfite was found in 60% of commercial dried garlic products purchased locally. The suitability of the Monier-Williams method for determining sulfite in garlic was discussed.
KW - drying
KW - food allergies
KW - food preservatives
KW - food safety
KW - formaldehyde
KW - garlic
KW - hydrochloric acid
KW - methodology
KW - potassium hydroxide
KW - sulfites
KW - sulfur dioxide
KW - Allium sativum
KW - Allium
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - allicin
KW - food hypersensitivity
KW - hydroxymethylsulfonate
KW - methods
KW - sulphites
KW - sulphur dioxide
KW - Crop Produce (QQ050)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033122628&site=ehost-live&scope=site
UR - email: gperfett@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of Universal Pre-enrichment broth for recovery of Salmonella from selected dairy foods.
AU - Hammack, T. S.
AU - Amaguaña, R. M.
AU - Johnson, M. L.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 4
SP - 714
EP - 718
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Microbiological Studies, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20033154073. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9000-71-9. Subject Subsets: Dairy Science; Agroforestry
N2 - The relative efficiencies of 2 Bacteriological Analytical Manual (BAM) pre-enrichments, lactose broth (LAC) and brilliant green water (BGW), were compared with Universal Pre-enrichment (UP) broth for the recovery of individual Salmonella serovars from instant nonfat dry milk (NFDM), dry whole milk (DWM), lactic casein (LC), and liquid whole milk (LWM). BGW was compared with UP broth for the analysis of NFDM and DWM but not with the other 2 matrixes. LAC was compared with UP broth for the analysis of LC and LWM. UP broth was made both from a commercial dehydrated preparation (UPC) and from individual ingredients (UPI). Bulk quantities of the selected dairy foods were inoculated with Salmonella serovars at levels intended to produce fractionally positive results, where at least half of the test portions analyzed, with one of the methods being evaluated, would be shown to be Salmonella-positive. For NFDM, in 6 of 9 experiments, with 2 different Salmonella serovars, BGW was significantly more productive than either UPI or UPC broth (p<0.05). Salmonella was recovered from 118 of 180 test portions with BGW, from 25 of 180 test portions with UPC, and from 14 of 180 test portions with UPI. For DWM, in 2 of 4 experiments, with 2 different Salmonella serovars, BGW was significantly more productive than either UPI or UPC broth (p<0.05). Salmonella was recovered from 67 of 80 test portions with BGW, from 36 of 80 test portions with UPC, and from 37 of 80 test portions with UPI. For LWM, in 9 of 9 experiments, with 3 different Salmonella serovars, there were no significant differences among the broths. Salmonella was recovered from 120 of 180 test portions with LAC, from 135 of 180 test portions with UPC, and from 129 of 180 test portions with UPI. For LC, in 5 of 7 experiments, with 2 different Salmonella serovars, both UPI and UPC broth were significantly more productive than LAC (p<0.05). Salmonella was recovered from 42 of 140 test portions with LAC, from 114 of 140 test portions with UPC, and from 114 of 140 test portions with UPI. In addition, overall results showed that UPC and UPI broths were equivalent for the recovery of Salmonella from the foods tested, without regard to their performance in comparison with either LAC or BGW.
KW - casein
KW - culture media
KW - dried milk
KW - food contamination
KW - liquid milk
KW - methodology
KW - microbial contamination
KW - milk products
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - dairy products
KW - food contaminants
KW - methods
KW - milk powder
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033154073&site=ehost-live&scope=site
UR - email: thomas.hammack@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of diminazene diaceturate (BerenilTM) in raw bovine milk.
AU - Roybal, J. E.
AU - Pfenning, A. P.
AU - Storey, J. M.
AU - Gonzales, S. A.
AU - Turnipseed, S. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 5
SP - 930
EP - 934
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Roybal, J. E.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20033197017. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 536-71-0, 908-53-4. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - A simple liquid chromatographic (LC) method is presented for the determination of diminazene (DZ) in raw bovine milk. DZ is extracted from raw milk by chilled aqueous centrifugation and is isolated from milk components on a cyano solid-phase extraction column. DZ is eluted by using a methanol-ion pairing reagent. A Phenomenex LUNA CN column and an acetonitrile-buffered mobile phase with a counter ion are used for gradient LC. The LC effluent is monitored at a detection wavelength of 372 nm by using a deuterium lamp. Under the parameters described, the retention time of DZ is 8-10 min with a peak area response of 6.5 mAU/ng. The method demonstrated excellent precision over all levels tested (25-400 ppb) with an overall average recovery of 90.4±14.5%. The method is applicable to the monitoring of milk for DZ residues at the 25 ppb level with a limit of quantitation of 10 ppb.
KW - analytical methods
KW - determination
KW - diminazene
KW - drug residues
KW - liquid chromatography
KW - methodology
KW - raw milk
KW - analytical techniques
KW - azidine
KW - berenil
KW - methods
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033197017&site=ehost-live&scope=site
UR - email: jroybal@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of ginsenosides (ginseng saponins) in dry root powder from Panax ginseng, Panax quinquefolius, and selected commercial products by liquid chromatography: interlaboratory study.
AU - Asafu-Adjaye, E. B.
AU - Wong SiuKay
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 6
SP - 1112
EP - 1123
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Asafu-Adjaye, E. B.: Product Quality Research Laboratory, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, HFD-941, NLRC Ste 2400, Rockville, MD 20857, USA.
N1 - Accession Number: 20043027984. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science
N2 - Twelve collaborating laboratories assayed 4 products, namely, P. ginseng, P. quinquefolius, and 2 ginseng products, for 6 ginsenosides: Rb1, Rb2, Rc, Rd, Re, and Rg1. Collaborators also received a negative control for the recovery study. Pure ginsenosides were provided as reference standards for the liquid chromatography (LC) analysis and the system suitability tests. The LC analyses were performed on the methanol extract using UV detection at 203 nm. For P. ginseng, individual ginsenosides were consistent in their means; repeatability standard deviations (RSDr) ranged from 4.17 to 5.09% and reproducibility standard deviations (RSDR) ranged from 7.27 to 11.3%. For P. quinquefolius, the Rb1 and Rb2 ginsenosides were higher and lower in concentration than P. ginseng, with RSDr values of 3.44 and 6.60% and RSDR values of 5.91 and 12.6%, respectively, and other analytes at intermediate precisions. For ginseng commercial products, RSDr values ranged from 3.39 to 8.12%, and RSDR values ranged from 7.65 to 16.5%. A recovery study was also conducted for 3 ginsenosides: Rg1, Re, and Rb1. The average recoveries were 99.9, 96.2, and 92.3%, respectively. This method is not applicable for the determination of Rg1 and Re in ginseng product at levels <300 mg/kg.
KW - chemical composition
KW - liquid chromatography
KW - medicinal plants
KW - medicinal properties
KW - methodology
KW - plant composition
KW - plant extracts
KW - powders
KW - roots
KW - saponins
KW - Panax ginseng
KW - Panax quinquefolius
KW - Panax
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Araliales
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - methods
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043027984&site=ehost-live&scope=site
UR - email: asafue@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gas chromatographic method for putrescine and cadaverine in shrimp.
AU - Rogers, P. L.
AU - Staruszkiewicz, W. F.
AU - Benner, R. A., Jr.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 6
SP - 1172
EP - 1178
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Rogers, P. L.: Washington Seafood Laboratory, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-426, Beltsville Research Facility, 8301 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 20043027991. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 462-94-2, 110-60-1. Subject Subsets: Agricultural Entomology
N2 - A gas-liquid chromatographic method developed for the determination of putrescine and cadaverine in fishery products was modified for application to the determination of diamines in shrimp. Addition of potassium chloride and hydrochloric acid to the methanol-water extraction solvent resulted in increased recovery of the diamines and minimized gel formation. The recovery of putrescine increased on average from 64 to 98%, and the recovery of cadaverine increased from 85 to 93%. The chromatographic separation of the derivatized diamines was significantly improved with a change from an OV-225 column (cyanopropyl methyl phenyl methyl silicone) to a more polar HP-Innowax column (crosslinked polyethylene glycol). Background levels of putrescine and cadaverine in known high-quality shrimp ranged from 0 to 0.7 ppm. Shrimp that failed sensory examination generally contained putrescine at levels, >4.8 ppm and cadaverine at levels >1.3 ppm.
KW - analytical methods
KW - cadaverine
KW - diamines
KW - food contamination
KW - food safety
KW - food spoilage
KW - gas chromatography
KW - putrescine
KW - sensory evaluation
KW - shrimps
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - 1,5-pentanediamine
KW - analytical techniques
KW - food contaminants
KW - Aquatic Produce (QQ060)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043027991&site=ehost-live&scope=site
UR - email: PRogers@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Indicator organisms for safety and quality - uses and methods for detection: minireview.
AU - Tortorello, M. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003///
VL - 86
IS - 6
SP - 1208
EP - 1217
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Tortorello, M. L.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Rd, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20043027996. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Human Nutrition
N2 - Indicator organisms have been used for nearly a century to assess the microbiological status of water and foods. Beginning with their use in water sanitation programs, their applications have been extended over the years to other products, and they have become important components of the microbiological testing programs of both industry and regulatory agencies. Functionally, they may be viewed as safety or quality indicators. Safety indicators suggest the presence of conditions associated with increased risk of exposure to a pathogen. Quality indicators assess conditions of importance to product manufacture or consumer acceptability. This minireview summarizes the history, use, and analytical methods for the most commonly used indicator organisms, including the aerobic plate count, yeasts and moulds, the coliform groups, Escherichia coil, Enterobacteriaceae, and Listeria.
KW - aerobes
KW - analytical methods
KW - coliform bacteria
KW - detection
KW - faecal coliforms
KW - food quality
KW - food safety
KW - indicators
KW - microbiological techniques
KW - moulds
KW - plate count
KW - reviews
KW - yeasts
KW - Enterobacteriaceae
KW - Escherichia coli
KW - Listeria
KW - fungi
KW - eukaryotes
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - aerobic micro-organisms
KW - aerobic microorganisms
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - fungus
KW - molds
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Microbiology (General) (ZZ390)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043027996&site=ehost-live&scope=site
UR - email: mlt@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute pesticide-related illnesses among working youths, 1988-1999.
AU - Calvert, G. M.
AU - Mehler, L. N.
AU - Rosales, R.
AU - Baum, L.
AU - Thomsen, C.
AU - Male, D.
AU - Shafey, O.
AU - Das, R.
AU - Lackovic, M.
AU - Arvizu, E.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2003///
VL - 93
IS - 4
SP - 605
EP - 610
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy, R-21, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20033064059. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Agricultural Entomology; Public Health
N2 - Objectives. The goal of this study was to describe the acute occupational pesticide-related illnesses among youths in the USA and to provide prevention recommendations. Methods. Survey data from 8 states (California, Texas, Washington, Oregon, New York, Florida, Louisiana and Arizona) and from poison control centre data were analysed. Illness incidence rates and incidence rate ratios were calculated. Results. A total of 531 youths were identified with acute occupational pesticide-related illnesses. Insecticides were responsible for most of these illnesses (68%), most of which were of minor severity (79%). The average annual incidence rate among youths aged 15 to 17 years was 20.4 per billion hours worked, and the incidence rate ratio among youths vs adults was 1.71 (95% confidence interval=1.53, 1.91). Conclusions. The present findings suggest the need for greater efforts to prevent acute occupational pesticide-related illnesses among adolescents.
KW - adolescents
KW - children
KW - illness
KW - nontarget effects
KW - occupational hazards
KW - pesticides
KW - spraymen
KW - Arizona
KW - California
KW - Florida
KW - Louisiana
KW - New York
KW - Oregon
KW - Texas
KW - USA
KW - Washington
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southwestern States of USA
KW - Pacific States of USA
KW - Gulf States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Delta States of USA
KW - West South Central States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Pacific Northwest States of USA
KW - Great Plains States of USA
KW - Southern Plains States of USA
KW - teenagers
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033064059&site=ehost-live&scope=site
UR - email: jac6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Student leadership in public health advocacy: lessons learned from the Hepatitis B Initiative.
AU - Hsu, L. D.
AU - DeJong, W.
AU - Hsia, R.
AU - Chang, M.
AU - Ryou, M.
AU - Yeh, E.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2003///
VL - 93
IS - 8
SP - 1250
EP - 1252
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Hsu, L. D.: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033146204. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Public Health
N2 - Increasing hepatitis B vaccination rates for Asian Americans and Pacific Islanders is a priority. Laws requiring vaccination prior to school enrollment have helped, yet many youths remain unvaccinated. The Hepatitis B Initiative (HBI), launched in 1997 and operated by public health and medical school students, provides free screenings and vaccinations to Boston's Asian American/Pacific Islander community, with a focus on youths. By October 2002, 997 hepatitis B virus patients from Boston's Chinatown had received free hepatitis B screenings. Of these, 384 patients (39%) were deemed susceptible to the hepatitis B virus and provided with free vaccination.
KW - Asians
KW - ethnic groups
KW - hepatitis B
KW - human diseases
KW - immunization
KW - vaccination
KW - Massachusetts
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033146204&site=ehost-live&scope=site
UR - email: wdejong@bu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Substance use among foreign-born youths in the United States: does the length of residence matter?
AU - Gfroerer, J. C.
AU - Tan, L. L.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2003///
VL - 93
IS - 11
SP - 1892
EP - 1895
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Gfroerer, J. C.: Substance Abuse and Mental Health Services Administration (SAMHSA), Office of Applied Studies, 5600 Fishers Lane, Room 16-105, Rockville, MD 20857, USA.
N1 - Accession Number: 20033201524. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5, 561-27-3. Subject Subsets: Public Health
N2 - A study was conducted to estimate the prevalence of substance use among foreign-born youths aged 12-17 years, and to investigate the association between acculturation (i.e., length of residence in the USA) and substance use in the USA. Data from the 1999 and 2000 National Household Survey on Drug Abuse were used. Prevalence estimates were computed for past-month use of cigarettes, alcohol, marijuana, cocaine, heroin, hallucinogens, inhalants and non-medical use of prescription-type pain relievers, tranquilizers, stimulants and sedatives. 50 947 youths were sampled, of which 7.1% were foreign-born. The prevalence of substance use was lower among foreign-born youths than US-born youths, especially for those aged 16-17 years. Logistic regression analysis showed that differences in prevalence between foreign- and US-born youths decreased with increasing length of residence in the USA among foreign-born youths. Foreign-born youths who resided in the USA for less than 5 years had lower prevalence than US-born youths. The prevalence estimates for foreign-born youths residing in the USA for 10 or more years were not significantly different from estimates for US-born youths, except for heavy alcohol intake. The prevalence estimates among Hispanics was higher for those who responded in English than for those who responded in Spanish. It is concluded that rates of substance use is lower among foreign-born youths than US-born youths; however, the risk of substance use increases as they become acculturated.
KW - acculturation
KW - adolescents
KW - alcohol intake
KW - alcoholism
KW - analgesics
KW - children
KW - cigarettes
KW - cocaine
KW - controlled substances
KW - drug abuse
KW - hallucinogens
KW - hemp
KW - heroin
KW - immigrants
KW - neuroleptics
KW - stimulants
KW - substance abuse
KW - tobacco smoking
KW - youth
KW - USA
KW - Cannabis sativa
KW - man
KW - Cannabis
KW - Cannabidaceae
KW - Urticales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - diacetylmorphine
KW - diamorphine
KW - drug use
KW - drugs (controlled substances)
KW - marijuana
KW - pain killers
KW - sedatives
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033201524&site=ehost-live&scope=site
UR - email: jgfroere@samhsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Healthy people 2010 and Asian Americans/Pacific Islanders: defining a baseline of information.
AU - Ghosh, C.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2003///
VL - 93
IS - 12
SP - 2093
EP - 2098
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Ghosh, C.: Health Resources and Services Administration, US Department of Health and Human Services (DHHS), Cambridge, Massachusetts, USA.
N1 - Accession Number: 20043001147. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Objectives: Healthy People 2010: Understanding and Improving Health lists six areas of disparity in minority health services: infant mortality, cancer, cardiovascular disease, HIV/AIDS, diabetes, and immunizations. This study compiles existing Asian American and Pacific Islander (AAPI) health data to establish a baseline. Methods: For federally-sponsored research (1986-2000), the Computer Retrieval of Information on Specific Projects (CRISP) database was analysed. AAPI initiatives were divided by subpopulation and disparity area. MEDLINE articles (1966-2000) were similarly scrutinized. Results: Few federal health-related grants (0.2%) and MEDLINE articles (0.01%) mention AAPIs. For the 6 disparity areas, significant AAPI data gaps remain. Conclusions: To reach the Healthy People 2010 goals and have useful data, researchers and grant makers must focus on obtaining baseline data for disaggregated AAPI subgroups.
KW - acquired immune deficiency syndrome
KW - Asians
KW - cardiovascular diseases
KW - databases
KW - diabetes
KW - ethnic groups
KW - ethnicity
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunization
KW - infant mortality
KW - infants
KW - information
KW - minorities
KW - neoplasms
KW - Pacific Islanders
KW - vaccination
KW - viral diseases
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - cancers
KW - data banks
KW - ethnic differences
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - viral infections
KW - Information and Documentation (CC300)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043001147&site=ehost-live&scope=site
UR - email: cghosh1@aol.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Phenotypic and genotypic characterization of competitive exclusion products for use in poultry.
AU - Wagner, R. D.
AU - Paine, D. D.
AU - Cerniglia, C. E.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2003///
VL - 94
IS - 6
SP - 1098
EP - 1107
CY - Oxford; UK
PB - Blackwell Science
SN - 1364-5072
AD - Wagner, R. D.: Microbiology Division, HFT-250, FDA National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033090024. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Veterinary Science; Veterinary Science; Poultry
N2 - Aims: Phenotypic and genotypic bacteria identification methods were compared for their efficacy in determining the composition of competitive exclusion (CE) products. Methods and Results: Phenotypic methods used for bacterial identification were fatty acid methyl ester profiles, biochemical assays and carbohydrate utilization profiles. Genotypic methods were MicroSeq16S rRNA sequence analysis and BLAST searches of the GenBank sequence database. Agreement between phenotypic and genotypic methods for identification of bacteria isolated from the Preempt CE product was 20%. A defined test mixture of bacteria was identified to the species level 100% by BLAST analysis, 64% by MicroSeq and 36% by phenotypic techniques. Conclusions: The wide range of facultative and obligate anaerobic bacteria present in a CE product are more accurately identified with 16S rRNA sequence analyses than with phenotypic identification techniques. Significance and Impact of the Study: These results will provide guidelines for manufacturers of CE products to submit more reliable product information for market approval by regulatory agencies.
KW - anaerobes
KW - analytical methods
KW - food contamination
KW - food safety
KW - genotypes
KW - microbial contamination
KW - molecular biology
KW - molecular genetics
KW - phenotypes
KW - poultry
KW - techniques
KW - anaerobic micro-organisms
KW - anaerobic microorganisms
KW - analytical techniques
KW - biochemical genetics
KW - domesticated birds
KW - food contaminants
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033090024&site=ehost-live&scope=site
UR - email: dwagner@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii.
AU - Golding, H.
AU - Aliberti, J.
AU - King, L. R.
AU - Manischewitz, J.
AU - Andersen, J.
AU - Valenzuela, J.
AU - Landau, N. R.
AU - Sher, A.
JO - Blood
JF - Blood
Y1 - 2003///
VL - 102
IS - 9
SP - 3280
EP - 3286
CY - Washington; USA
PB - American Society of Hematology
SN - 0006-4971
AD - Golding, H.: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bldg 29A, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033192773. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Protozoology
N2 - The activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of human immunodeficiency virus type 1 (HIV-1) cell fusion and infection with cell-free virus. T. gondii C-18 efficiently blocked syncytium formation between human T cells and effector cells expressing R5 but not X4 envelopes. Neither human nor Plasmodium falciparum cyclophilins possess such inhibitory activity. Importantly, C-18 protected peripheral blood leukocytes from infection with multiple HIV-1 R5 primary isolates from several clades. C-18 bound directly to human CCR5, and this interaction was partially competed by the β-chemokine macrophage inflammatory protein 1β (MIP-1β) and by HIV-1 R5 gp120. In contrast to several other antagonists of HIV coreceptor function, C-18 mediated inhibition did not induce β-chemokines or cause CCR5 down-modulation, suggesting direct blocking of envelope binding to the receptor. These data support the further development of C-18 derivatives as HIV-1 inhibitors for preventing HIV-1 transmission and for postexposure prophylaxis.
KW - antagonists
KW - cell fusion
KW - chemokines
KW - HIV-1 infections
KW - human diseases
KW - leukocytes
KW - syncytia
KW - T lymphocytes
KW - viral diseases
KW - Human immunodeficiency virus 1
KW - Plasmodium falciparum
KW - Toxoplasma gondii
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - cyclophilins
KW - human immunodeficiency virus type 1
KW - leucocytes
KW - macrophage inflammatory protein
KW - T cells
KW - viral infections
KW - white blood cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033192773&site=ehost-live&scope=site
UR - email: goldingh@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Setting dietary guidelines: the US process.
AU - McMurry, K. Y.
T3 - Dietary Guidelines: Past Experience and New Approaches, University of Toronto, April 30 - May 1, 2002
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2003///
VL - 103
SP - S10
EP - S16
CY - Chicago; USA
PB - American Dietetic Association
SN - 0002-8223
AD - McMurry, K. Y.: US Department of Health and Human Services, Office of Public Health and Science, Office of Disease Prevention and Health Promotion, 200 Independence Avenue SW, Room 738G, Washington, DC 20201, USA.
N1 - Accession Number: 20043001949. Publication Type: Journal Article; Conference paper. Note: Dietary Guidelines: Past Experience and New Approaches, University of Toronto, April 30 - May 1, 2002 Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - Nutrition and Your Health: Dietary Guidelines for Americans has been issued jointly by the US Departments of Health and Human Services (HHS) and Agriculture (USDA) every five years since 1980. The Dietary Guidelines form the cornerstone of federal nutrition policy and provide the basis for all federal nutrition education activities. Beginning with the 1985 edition, USDA and HHS have appointed a Dietary Guidelines Advisory Committee of prominent experts in nutrition and health to review recent advances in scientific and medical knowledge and to recommend revisions of the Dietary Guidelines, if warranted, to the Secretaries of HHS and USDA. The Committee's deliberations are informed by evidence-based reviews, consensus documents, peer-reviewed research studies, and by written and oral public comments. The Departments review the Committee's recommendations and rationale, make any necessary revisions, and jointly issue the final edition. Nutrition and Your Health: Dietary Guidelines for Americans is based on the best available science. Ultimately, its goal is to promote better health through food choices and physical activity. The Dietary Guidelines have been referred to as a "gold standard" of nutrition advice, amid often confusing messages about nutrition and health.
KW - dietary guidelines
KW - health
KW - health promotion
KW - nutrition
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043001949&site=ehost-live&scope=site
UR - email: kmcmurry@osophs.dhhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Priorities for development of research methods in occupational cancer.
AU - Ward, E. M.
AU - Schulte, P. A.
AU - Bayard, S.
AU - Blair, A.
AU - Brandt-Rauf, P.
AU - Butler, M. A.
AU - Dankovic, D.
AU - Hubbs, A. F.
AU - Jones, C.
AU - Karstadt, M.
AU - Kedderis, G. L.
AU - Melnick, R.
AU - Redlich, C. A.
AU - Rothman, N.
AU - Savage, R. E.
AU - Sprinker, M.
AU - Toraason, M.
AU - Weston, A.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003///
VL - 111
IS - 1
SP - 1
EP - 12
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Ward, E. M.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20033119982. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the ability to further define research needs and develop strategies to enhance or augment research in each priority area. This article is a product of that process. Focus on occupational cancer research methods is important because occupational factors play a significant role in a number of cancers, resulting in significant morbidity and mortality, and also because occupational cohorts (because of higher exposure levels) often provide unique opportunities to evaluate health effects of environmental toxicants and understand the carcinogenic process in humans. Despite an explosion of new methods for cancer research in general, these have not been widely applied to occupational cancer research. In this article we identify needs and gaps in occupational cancer research methods in four broad areas: identification of occupational carcinogens, design of epidemiological studies, risk assessment, and primary and secondary prevention. Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists.
KW - human diseases
KW - neoplasms
KW - occupational hazards
KW - organization of research
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - research organization
KW - Research (AA500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033119982&site=ehost-live&scope=site
UR - email: pas4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Skin as a route of exposure and sensitization in chronic beryllium disease.
AU - Tinkle, S. S.
AU - Antonini, J. M.
AU - Rich, B. A.
AU - Roberts, J. R.
AU - Salmen, R.
AU - DePree, K.
AU - Adkins, E. J.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003///
VL - 111
IS - 9
SP - 1202
EP - 1208
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Tinkle, S. S.: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20033142465. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - Chronic beryllium disease is an occupational lung disease that begins as a cell-mediated immune response to beryllium. Although respiratory and engineering controls have significantly decreased occupational beryllium exposures over the last decade, the rate of beryllium sensitization has not declined. We hypothesized that skin exposure to beryllium particles would provide an alternative route for sensitization to this metal. We employed optical scanning laser confocal microscopy and size-selected fluorospheres to demonstrate that 0.5- and 1.0-µm particles, in conjunction with motion, as at the wrist, penetrate the stratum corneum of human skin and reach the epidermis and, occasionally, the dermis. The cutaneous immune response to chemical sensitizers is initiated in the skin, matures in the local lymph node (LN), and releases hapten-specific T cells into the peripheral blood. Topical application of beryllium to C3H mice generated beryllium-specific sensitization that was documented by peripheral blood and LN beryllium lymphocyte proliferation tests (BeLPT) and by changes in LN T-cell activation markers, increased expression of CD44, and decreased CD62L. In a sensitization-challenge treatment paradigm, epicutaneous beryllium increased murine ear thickness following chemical challenge. These data are consistent with development of a hapten-specific, cell-mediated immune response following topical application of beryllium and suggest a mechanistic link between the persistent rate of beryllium worker sensitization and skin exposure to fine and ultrafine beryllium particles.
KW - berylliosis
KW - beryllium
KW - chronic course
KW - exposure
KW - human diseases
KW - immune response
KW - laboratory animals
KW - skin
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - dermis
KW - immunity reactions
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033142465&site=ehost-live&scope=site
UR - email: sft3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury.
AU - Ma, J. Y. C.
AU - Rengasamy, A.
AU - Frazer, D.
AU - Barger, M. W.
AU - Hubbs, A. F.
AU - Battelli, L.
AU - Tomblyn, S.
AU - Stone, S.
AU - Castranova, V.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003///
VL - 111
IS - 9
SP - 1215
EP - 1221
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Ma, J. Y. C.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20033142467. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 50812-37-8, 9001-60-9.
N2 - Asphalt fumes are complex mixtures of various organic compounds, including polycyclic aromatic hydrocarbons (PAHs). PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert toxic/carcinogenic effects. The present study was carried out to characterize the acute pulmonary inflammatory responses and the alterations of pulmonary xenobiotic pathways in rats exposed to asphalt fumes by inhalation. Rats were exposed at various doses and time periods to air or to asphalt fumes generated at paving temperatures. To assess the acute damage and inflammatory responses, differential cell counts, acellular lactate dehydrogenase (LDH) activity, and protein content of bronchoalveolar lavage fluid were determined. Alveolar macrophage (AM) function was assessed by monitoring generation of chemiluminescence and production of tumour necrosis factor-α and interleukin-1. Alteration of pulmonary xenobiotic pathways was determined by monitoring the protein levels and activities of P-450 isozymes (CYP1A1 and CYP2B1), glutathione S-transferase (GST), and NADPH:quinone oxidoreductase (QR). The results show that acute asphalt fume exposure did not cause neutrophil infiltration, alter LDH activity or protein content, or affect AM function, suggesting that short-term asphalt fume exposure did not induce acute lung damage or inflammation. However, acute asphalt fume exposure significantly increased the activity and protein level of CYP1A1 whereas it markedly reduced the activity and protein level of CYP2B1 in the lung. The induction of CYP1A1 was localized in nonciliated bronchiolar epithelial (Clara) cells, alveolar septa, and endothelial cells by immunofluorescence microscopy. Cytosolic QR activity was significantly elevated after asphalt fume exposure, whereas GST activity was not affected by the exposure. This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung.
KW - bitumen
KW - enzyme activity
KW - exposure
KW - fumes
KW - glutathione transferase
KW - inhalation
KW - isoenzymes
KW - laboratory animals
KW - lactate dehydrogenase
KW - lungs
KW - macrophages
KW - neutrophils
KW - polycyclic hydrocarbons
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - asphalt
KW - isozymes
KW - ligandin
KW - polycyclic aromatic hydrocarbons
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033142467&site=ehost-live&scope=site
UR - email: jym1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Economic analysis of promotion of hepatitis B vaccinations among Vietnamese-American children and adolescents in Houston and Dallas.
AU - Zhou, F. J.
AU - Euler, G. L.
AU - McPhee, S. J.
AU - Thoa Nguyen
AU - Tram Lam
AU - Wong, C.
AU - Mock, J.
JO - Pediatrics
JF - Pediatrics
Y1 - 2003///
VL - 111
IS - 6(1 of 3)
SP - 1289
EP - 1296
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Zhou, F. J.: National Immunization Program, CDC, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Mail stop E-52, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033120233. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Objective: To ascertain the cost-effectiveness and benefit-cost ratios of 2 public health campaigns conducted in Dallas and Houston (Texas, USA) during 1998-2000 for "catch-up" hepatitis B vaccination of Vietnamese-Americans born during 1984-93. Design: Programme evaluation. Participants: 14 349 Vietnamese-American children and adolescents. Interventions. Media-led information and education campaign in Houston, and community mobilization strategy in Dallas. Outcomes were compared with a control site: Washington, DC. Main outcome measures. Receipt of 1, 2 or 3 doses of hepatitis B vaccine before and after the interventions, costs of interventions, cost-effectiveness ratios for intermediate outcomes, intervention cost per discounted year of life saved, and benefit-cost ratio of the interventions. Results: The number of children who completed the series of 3 hepatitis B vaccine doses increased by 1176 at a total cost of $313 904 for media intervention, and by 390 and at $169 561 for community mobilization. Costs per child receiving any dose, per dose and per completed series were $363, $101 and $267 for media intervention and $387, $136 and $434 for community mobilization, respectively. For media intervention, the intervention cost per discounted year of life saved was $9954 and 131 years of life were saved; for community mobilization, estimates were $11 759 and 60 years of life. The benefit-cost ratio was 5.26:1 for media intervention and 4.47:1 for community mobilization. Conclusion: Although the increases in the number of children who completed 3 doses were modest for both the Houston and Dallas areas, both media education and, to a lesser degree, community mobilization interventions proved cost-effective and cost-beneficial.
KW - adolescents
KW - campaigns
KW - children
KW - community involvement
KW - cost benefit analysis
KW - costs
KW - economic analysis
KW - ethnic groups
KW - health education
KW - health programs
KW - health promotion
KW - hepatitis B
KW - human diseases
KW - immunization
KW - mass media
KW - vaccination
KW - vaccines
KW - Texas
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southern States of USA
KW - Southwestern States of USA
KW - costings
KW - immune sensitization
KW - news media
KW - teenagers
KW - United States of America
KW - Vietnamese-Americans
KW - Education and Training (CC100)
KW - Health Economics (EE118) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Community Participation and Development (UU450) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033120233&site=ehost-live&scope=site
UR - email: faz1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - International environmental health for the pediatrician: case study of lead poisoning.
AU - Falk, H.
A2 - Balk, S. J.
A2 - Shea, K. M.
JO - Pediatrics
JF - Pediatrics
Y1 - 2003///
VL - 112
IS - 1(2 of 2)
SP - 259
EP - 264
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Falk, H.: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, 1600 Clifton Rd NE, MS E-28, Atlanta, GA 30341, USA.
N1 - Accession Number: 20033143720. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 39 ref. Registry Number: 7439-92-1. Subject Subsets: Tropical Diseases
N2 - Childhood lead poisoning is a preventable illness. In the past 3 decades, removal of key lead sources and prevention of exposure in the USA have led to dramatic decreases in population blood lead concentrations and also in instances of severe lead poisoning requiring treatment. From an international perspective, childhood lead poisoning seems to be of greatest concern in Developing Countries. The phasing out of lead from gasoline is a critical first step in decreasing worldwide blood lead concentrations. However, many focal sources that can cause lead poisoning remain, such as lead from flour mills, lead-glazed ceramics, mining and smelting, and battery repair and recycling. A large and diverse country, such as India, may have many sources of lead. The challenge will be for Developing Countries to implement effective national and regional efforts to address their specific sources of lead.
KW - ceramics
KW - children
KW - environment
KW - flour mills
KW - heavy metals
KW - lead
KW - lead poisoning
KW - mining
KW - reviews
KW - toxic substances
KW - toxicity
KW - Developing Countries
KW - India
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - poisons
KW - Third World
KW - Underdeveloped Countries
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Industrial Wastes and Effluents (XX400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143720&site=ehost-live&scope=site
UR - email: hxf1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki syndrome hospitalizations in the USA, 1997 and 2000.
AU - Holman, R. C.
AU - Curns, A. T.
AU - Belay, E. D.
AU - Steiner, C. A.
AU - Schonberger, L. B.
JO - Pediatrics
JF - Pediatrics
Y1 - 2003///
VL - 112
IS - 3(1 of 2)
SP - 495
EP - 501
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Holman, R. C.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, MS A-39, Atlanta, GA 30333, USA.
N1 - Accession Number: 20033179060. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - Objective. To estimate the incidence and describe the epidemiologic characteristics of Kawasaki syndrome (KS) among children in the USA. Methods. Hospital discharge records with a KS diagnosis among patients <18 years of age were obtained from the 1997 and 2000 Kids' Inpatient Database and weighted to estimate the number and rate of KS-associated hospitalizations for the USA. Results. In 2000, ~4248 hospitalizations associated with KS occurred in the USA, and the median age of patients at admission was 2 years. Children <5 years of age accounted for 3277 of these KS hospitalizations (77%) and had a KS hospitalization rate of 17.1 per 100 000 children. This rate was similar to the 1997 rate of 17.6 per 100 000 children. The KS hospitalization rate was significantly higher for infants <1 year of age than for children 1 to 4 years of age (19.8 and 16.4 per 100 000 children, respectively). The rate of KS hospitalizations among children aged <5 years was highest among Asian and Pacific Islander children and was followed by the rate for black children (39.0 and 19.7 per 100 000 children, respectively). No deaths associated with KS were reported among hospitalized children. The median charge for a KS hospitalization was $7779 (mean $10 725) and the total annual charges for KS hospitalizations in 2000 were approximately $35 million among children <5 years of age. Conclusions. Among children <5 years of age, the annual KS-associated hospitalization rates were similar for 1997 and 2000. The epidemiologic characteristics and hospitalization rates for KS at a national level were consistent with those reported from earlier studies, suggesting that the incidence for KS has not markedly changed in the USA during the past decade.
KW - age
KW - children
KW - costs
KW - disease incidence
KW - epidemiology
KW - hospitals
KW - human diseases
KW - infants
KW - Kawasaki disease
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - mucocutaneous lymph node syndrome
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033179060&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of human rotavirus serotype G6 in Hungary.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Glass, R. I.
AU - Szucs, G.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2003///
VL - 130
IS - 1
SP - 107
EP - 112
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of the State Public Health Service, Szabadság út 7., Pécs, H-7623, Hungary.
N1 - Accession Number: 20033025594. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - During an ongoing survey of human rotavirus serotypes, we demonstrated for the first time the circulation of serotype G6 in two regions of Hungary. Of five rotavirus seasons surveyed to date (1994-9), serotype G6 was found in all seasons except 1994-5 at an overall prevalence of 1.4% (17 of 1252) and ranging from 0.6 to 4.5%. Children infected with G6 strains were older (mean age, 3.3 years) than children infected with the four (G1-G4) globally common serotypes (mean age, 2.1 years; unpaired Student's t test, P<0.001). Our data indicate that rotavirus serotype G6 may be an epidemiologically important G serotype in Hungary.
KW - age
KW - children
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - strains
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033025594&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and use of an ELISA test to detect IgE antibody to Cry9c following possible exposure to bioengineered corn.
AU - Raybourne, R. B.
AU - Williams, K. M.
AU - Vogt, R.
AU - Reissman, D. B.
AU - Winterton, B. S.
AU - Rubin, C.
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
Y1 - 2003///
VL - 132
IS - 4
SP - 322
EP - 328
CY - Basel; Switzerland
PB - S Karger AG
SN - 1018-2438
AD - Raybourne, R. B.: Immunobiology Branch, Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20043010522. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9007-49-2, 37341-29-0, 308067-57-4. Subject Subsets: Agricultural Biotechnology; Maize; Plant Breeding; Postharvest Research; Public Health
N2 - Background: Starlink, a variety of corn genetically engineered to contain the insecticidal protein Cry9c, had not been approved for human consumption because it possessed some characteristics associated with allergenic proteins. However, in the fall of 2000 cry9c DNA was detected in several corn-containing products, suggesting that Starlink corn had entered the human food supply. Subsequently, consumers, following consumption of corn products, reported a number of adverse health events, possibly consistent with allergic reaction. Methods: To investigate the possibility of allergic reactions due to Cry9c in these consumers an ELISA test was developed for the purpose of detecting IgE antibodies to Cry9c and blood samples were taken from 18 people who self-reported allergic reactions [USA]. Sera collected prior to the 1996 development of Starlink were used as negative controls. Results: None of the adverse event sera were found to be reactive with recombinant Cry9c antigen, based on comparison with normal controls. Although a known human positive control serum containing IgE specific for Cry9c was not available, other controls were incorporated into the ELISA protocol, including the use of sera from subjects allergic to other allergens and their homologous antigens (cat, grass, groundnut) to validate the IgE detection reagents. Conclusions: While the results do not support the likely occurrence of allergic reactions to Cry9c, such reactions cannot be ruled out, nor can the possibility that sera might react with unique glycosylated epitopes of Cry9c that may be expressed in the corn plant/seed.
KW - adverse effects
KW - allergens
KW - allergic reactions
KW - allergies
KW - antibodies
KW - antigens
KW - detection
KW - DNA
KW - ELISA
KW - epitopes
KW - food consumption
KW - food products
KW - food supply
KW - genetic engineering
KW - genetically engineered organisms
KW - IgE
KW - immunoglobulins
KW - maize
KW - proteins
KW - recombinant antigens
KW - transgenic plants
KW - Georgia
KW - USA
KW - man
KW - plants
KW - Zea mays
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - adverse reactions
KW - antigenic determinants
KW - antigenicity
KW - corn
KW - deoxyribonucleic acid
KW - enzyme linked immunosorbent assay
KW - gamma-globulins
KW - genetic manipulation
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - immune globulins
KW - immunogens
KW - reagin
KW - reaginic antibodies
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043010522&site=ehost-live&scope=site
UR - email: richard.raybourne@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lutein interacts with ascorbic acid more frequently than with α-tocopherol to alter biomarkers of oxidative stress in female Zucker obese rats.
AU - Blakely, S.
AU - Herbert, A.
AU - Collins, M.
AU - Jenkins, M.
AU - Mitchell, G.
AU - Grundel, E.
AU - O'Neill, K. R.
AU - Khachik, F.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003///
VL - 133
IS - 9
SP - 2838
EP - 2844
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Blakely, S.: Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20033187678. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 59-02-9, 50-81-7, 9013-66-5, 9004-10-8, 542-78-9, 9054-89-1, 1406-18-4, 58-95-7, 127-40-2. Subject Subsets: Human Nutrition
N2 - The influence of dietary lutein, with and without moderate amounts of vitamin C (VC) or vitamin E (VE), on biomarkers of oxidative stress was examined in rats. Nine groups of immature Zucker obese (fa/fa) and lean female rats (8/group) consumed ad libitum for 8 weeks the AIN-93G diet (control) to which was added either dl-α-tocopheryl acetate (VE) at 0.60 mg/kg or ascorbic acid (VC) at 0.75 mg/kg diet. Each of these diets contained lutein oil (FloraGlo) at 0.5 (Lut0.5) or 1.0 (Lut1.0) mg/kg diet. Weight gain, food efficiency and relative liver weight were higher in obese than in lean rats. Although liver malondialdehyde (MDA) concentrations were significantly higher in obese than in lean rats, the levels were significantly lower in obese rats fed VE, VE-Lut and VC-Lut0.5 compared with other obese groups. The accumulation of α-tocopherol in liver was 6- and 3-times greater in the VE and VE-Lut1.0 groups, respectively, compared with the obese and lean control groups. Lutein reduced the activity of superoxide dismutase (SOD) in obese rats, independent of VC or VE, and raised the activity of glutathione peroxidase to higher levels in lean rats when combined with VC. Plasma insulin levels were dramatically higher in obese compared with lean rats, but significantly lower in obese rats fed VC-Lut0.5, VE-Lut1.0 and Lut1.0 compared with the control group. These results suggest that lutein independently reduces the activity of SOD and alters more biomarkers of oxidative stress when combined with vitamin C than with vitamin E, and that vitamin E reduces liver lipid peroxidation in obese rats when the accumulation of liver α-tocopherol is very high.
KW - alpha-tocopherol
KW - animal models
KW - antioxidant properties
KW - antioxidants
KW - ascorbic acid
KW - biochemical markers
KW - diets
KW - enzyme activity
KW - females
KW - glutathione peroxidase
KW - insulin
KW - laboratory animals
KW - lipid peroxidation
KW - liver
KW - malondialdehyde
KW - nutrient nutrient interactions
KW - obesity
KW - oxidative stress
KW - superoxide dismutase
KW - vitamin E
KW - vitamin E acetate
KW - weight
KW - weight gain
KW - xanthophyll
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alpha-tocopheryl acetate
KW - anti-oxidant properties
KW - biomarkers
KW - fatness
KW - lutein
KW - tocopheryl acetate
KW - vitamin C
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033187678&site=ehost-live&scope=site
UR - email: sblakely@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical applications of proteomics.
AU - Petricoin, E. F.
AU - Liotta, L. A.
A2 - Kim, Y. S.
A2 - Milner, J. A.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003///
VL - 133
SP - 2476S
EP - 2484S
CY - Bethesda; USA
PB - American Society for Nutritional Sciences
SN - 0022-3166
AD - Petricoin, E. F.: Office of the Director, Center for Biologic Evaluation and Research, U. S. Food and Drug Administration, National Cancer Institute Clinical Proteomics Program, Rockville, MD 20852, USA.
N1 - Accession Number: 20033175657. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 83 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Proteomics, the systematic evaluation of changes in the protein constituency of a cell, is more than just the generation of lists of proteins that increase or decrease in expression as a cause or consequence of disease. The ultimate goal is to characterize the information flow through protein pathways that interconnect the extracellular microenvironment with the control of gene transcription. The nature of this information can be a cause or a consequence of disease processes. Clinical applications of proteomics involve the use of proteomic technologies at the bedside. The analysis of human cancer as a model for how proteomics can have an impact at the bedside is now employing several new proteomic technologies that are being developed for early detection, therapeutic targeting and finally, patient-tailored therapy.
KW - diagnosis
KW - human diseases
KW - neoplasms
KW - proteins
KW - proteomics
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - cell signalling
KW - Physiology of Human Nutrition (VV120)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033175657&site=ehost-live&scope=site
UR - email: petricoin@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Routine vitamin supplementation to prevent cancer and cardiovascular disease: recommendations and rationale.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2003///
VL - 139
IS - 1
SP - 51
EP - 55
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20033116773. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 42 ref. Registry Number: 50-81-7, 7235-40-7, 68-26-8, 1406-18-4. Subject Subsets: Human Nutrition; Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on routine vitamin supplementation (e.g., vitamins A, C and E, β-carotene, antioxidant vitamin C combinations and multiple vitamin combinations) to prevent cancer and cardiovascular disease and the supporting scientific evidence. Part of the information on which this statement is based, including evidence tables and references, is available in the accompanying article on vitamins to prevent cardiovascular disease in this issue. More complete information can be found in the summaries of the evidence on vitamins to prevent cancer and vitamins to prevent cardiovascular disease, available on the USPSTF Web site (http://www.preventiveservices.ahrq.gov) and through the National Guideline Clearinghouse (http://www.guideline.gov). The summaries of the evidence on these topics and the recommendation statement are also available in print through subscription to the Guide to Clinical Preventive Services, Third Edition: Periodic Updates. A subscription costs $60 and can be ordered through the Agency for Healthcare Research and Quality Publications Clearinghouse (call 800-358-9295 or e-mail ahrqpubs@ahrq.gov).
KW - antioxidants
KW - ascorbic acid
KW - beta-carotene
KW - cardiovascular diseases
KW - disease prevention
KW - guidelines
KW - human diseases
KW - neoplasms
KW - retinol
KW - vitamin E
KW - vitamin supplements
KW - vitamins
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - cancers
KW - multivitamins
KW - recommendations
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A1
KW - vitamin C
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033116773&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for obesity in adults: recommendations and rationale.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2003///
VL - 139
IS - 11
SP - 930
EP - 932
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20033209475. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for obesity in adults based on the USPSTF's examination of evidence specific to obesity and overweight in adults, and updates the 1996 recommendations on this topic. The complete USPSTF recommendation and rationale statement on this topic, which includes a brief review of the supporting evidence, is available through the USPSTF Web site (www.preventiveservices.gov), the National Guideline Clearinghouse (www.guideline.gov), and in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov). The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the summary of the evidence and systematic evidence review on the Web sites already mentioned. The summary of the evidence is also available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse.
KW - adults
KW - guidelines
KW - obesity
KW - overweight
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - recommendations
KW - screening tests
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033209475&site=ehost-live&scope=site
UR - email: ahrqpubs@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Three-year prevalence and incidence of diabetes among American Indian youth in Montana and Wyoming, 1999 to 2001.
AU - Moore, K. R.
AU - Harwell, T. S.
AU - McDowall, J. M.
AU - Helgerson, S. D.
AU - Gohdes, D.
JO - Journal of Pediatrics
JF - Journal of Pediatrics
Y1 - 2003///
VL - 143
IS - 3
SP - 368
EP - 371
CY - St Louis; USA
PB - Mosby Inc.
SN - 0022-3476
AD - Moore, K. R.: Billings Area Indian Health Service, Billings, Montana, USA.
N1 - Accession Number: 20033178820. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - The medical records American Indian youth (<20 years old) seen in hospitals in Montana and Wyoming, USA for possible diabetes mellitus during 1999-2001 were reviewed. The incidence rate per 100 000 for diabetes overall was 33.6/100 000 The incidence rate for probable type 2 diabetes was 23.3/100 000 and that for probable type 1 diabetes was 5.8/100 000. Of the 23 incident cases identified over the 3-year period, >70% were categorized as having probable type 2 diabetes, 17% as probable type 1, 9 could not be classified, and one had diabetes secondary to another condition. Mean age at diagnosis for cases categorized as probable type 2 was 13.2 years and 50% were female. Of those categorized as having probable type 1 diabetes, the mean age at diagnosis was 6.0 years and 25% were female. Of the cases that could not be classified, the mean age at diagnosis was 12.4 years and all were female.
KW - adolescents
KW - American indians
KW - children
KW - diabetes mellitus
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - Montana
KW - USA
KW - Wyoming
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - teenagers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033178820&site=ehost-live&scope=site
UR - email: tharwell@state.mt.us
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats.
AU - Turesky, R. J.
AU - Richoz, J.
AU - Constable, A.
AU - Curtis, K. D.
AU - Dingley, K. H.
AU - Turteltaub, K. W.
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2003///
VL - 145
IS - 3
SP - 251
EP - 265
CY - Shannon; Irish Republic
PB - Elsevier Scientific Publishers Ireland Ltd
SN - 0009-2797
AD - Turesky, R. J.: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033118063. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2, 6556-12-3, 50812-37-8. Subject Subsets: Human Nutrition
N2 - The effects of coffee on the metabolism and genotoxicity of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were investigated. Coffee diminished the bacterial mutagenicity of PhIP in the Ames reversion assay through inhibition of cytochrome P450 1A2 (CYP1A2), a key enzyme involved in the metabolic activation of PhIP. When given as part of the diet (0, 1 or 5% w/w) to male Fischer-344 rats for 2 weeks, coffee affected the expression of hepatic enzymes involved in PhIP metabolism. Coffee increased the expression of CYP1A2 by 16-fold in the 5% coffee-treated group, and approximately half of this inductive effect was attributed to caffeine. Coffee also increased the expression of enzymes involved in the detoxication of PhIP. A 2-fold increase in expression of glutathione S-transferase alpha was observed, UDP-glucuronosyl transferase (UGTs) activities of p-nitrophenol increased 2-fold, while N2- and N3-glucuronidation of the genotoxic metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (HONH-PhIP) increased by 1.3-fold in the 5% coffee-treated over the control group. The amount of PhIP (0.75 mg/kg, 24 h) eliminated in urine as the N2- and N3-glucuronide conjugates of HONH-PhIP increased by 1.8- and 2.5-fold, respectively, in the 5% coffee-treated group over control rats, suggesting either increased rates of N-oxidation of PhIP or N-glucuronidation of HONH-PhIP. Despite the strong induction of CYP1A2, there was no increase in PhIP-DNA adduct formation in colon and pancreas while liver adducts decreased by 50% over control animals. These data suggest that the effect of coffee on inhibition of PhIP N-oxidation and ensuing DNA damage is more important in vivo than its effect on induction of PhIP N-hydroxylation.
KW - carcinogens
KW - coffee
KW - cytochrome P-450
KW - enzyme activity
KW - gene expression
KW - genes
KW - genotoxicity
KW - glucuronic acid
KW - glutathione transferase
KW - laboratory animals
KW - liver
KW - metabolism
KW - Coffea
KW - rats
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
KW - ligandin
KW - UDP-glucuronosyltransferase
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033118063&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T56-482NJKS-2&_user=10&_handle=W-WA-A-A-AU-MsSAYVA-UUA-AUCEYWDEWW-ADUEDBUCA-AU-U&_fmt=summary&_coverDate=06%2F15%2F2003&_rdoc=2&_orig=browse&_srch=%23toc%234994%232003%23998549996%23424577!&_cdi=4994&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=cd48bc7d3795d433d8282316a394fb50
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of dietary soy and estrous cycle on adrenal cytochrome P450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats.
AU - Fu, X.
AU - Blaydes, B. S.
AU - Weis, C. C.
AU - Latendresse, J. R.
AU - Muskhelishvili, L.
AU - Sutter, T. R.
AU - Delclos, K. B.
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2003///
VL - 146
IS - 3
SP - 273
EP - 284
CY - Shannon; Irish Republic
PB - Elsevier Scientific Publishers Ireland Ltd
SN - 0009-2797
AD - Fu, X.: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043051101. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2. Subject Subsets: Human Nutrition; Soyabeans
N2 - Cytochrome P450 1B1 (CYP1B1) has been shown to be important in the bioactivation of 7,12-dimethylbenz[a]anthracene (DMBA) to an adrenal toxin in rats. We investigated the effects of diet and stage of oestrous cycle on CYP1B1 expression in rat adrenal glands and on DMBA metabolism by rat adrenal and hepatic microsomes. Female Sprague-Dawley (SD) rats were placed on either standard soy-containing NIH-31 rat chow or soy- and alfalfa-free 5K96 diet from postnatal day (PND) 21 until sacrifice at PND50±5. Stage of oestrous at sacrifice was assessed by vaginal cytology and confirmed by histological examination of the vagina. Dietary soy at the level present in NIH-31 diet did not affect serum oestrogen and progesterone levels. Immunohistochemical analysis confirmed that CYP1B1 was exclusively expressed in the zona fasciculata and zona reticularis in adrenal cortex, which are the regions vulnerable to DMBA-induced adrenal necrosis. Adrenal CYP1B1 protein expression, 3H-DMBA depletion, and formation of DMBA-3,4-, and -8,9-dihydrodiols by adrenal microsomes were greater in animals fed 5K96 diet, and the stage of the oestrous cycle affected these parameters only in the soy-free 5K96 diet. In hepatic microsomes, the formation of DMBA-3,4-dihydrodiol, 7-hydroxy- and 12-hydroxy-DMBA were lower in animals fed NIH-31 diet than in those fed 5K96 diet. Thus, dietary soy and the oestrous cycle appear to regulate adrenal CYP1B1 expression and DMBA metabolism by both adrenal and hepatic microsomes. The use of different basal diets containing variable levels of soy components may affect certain toxicity assessments.
KW - adrenal glands
KW - animal models
KW - cytochrome P-450
KW - diet
KW - laboratory animals
KW - liver
KW - oestrogens
KW - oestrous cycle
KW - soyabeans
KW - toxicity
KW - Glycine (Fabaceae)
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - adrenals
KW - breeding cycle
KW - estrogens
KW - estrous cycle
KW - reproductive cycle
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043051101&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T56-4B0SW80-2&_user=10&_handle=B-WA-A-A-AA-MsSAYZW-UUA-AUYBVEAYWE-AUYAUDWZWE-BBYBZVDBV-AA-U&_fmt=summary&_coverDate=12%2F15%2F2003&_rdoc=6&_orig=browse&_srch=%23toc%234994%232003%23998539996%23471148!&_cdi=4994&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=17e51ede5bf05aa998fe9bd2a57024dc
UR - email: bdelclos@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequence heterogeneity among human picobirnaviruses detected in a gastroenteritis outbreak.
AU - Bányai, K.
AU - Jakab, F.
AU - Reuter, G.
AU - Bene, J.
AU - Új, M.
AU - Melegh, B.
AU - Szucs, G.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2003///
VL - 148
IS - 12
SP - 2281
EP - 2291
CY - Wien; Austria
PB - Springer-Verlag Wien
SN - 0304-8608
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7., H-7621 Pécs, Hungary.
N1 - Accession Number: 20033217629. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - Human picobirnaviruses characterised in this study were serendipitously detected in a non-bacterial gastroenteritis outbreak when specimens were examined for the presence of human rotaviruses using polyacrylamide gel electrophoresis. Of ten stool samples sent for virological examination, two, three, and one specimens were positive for human caliciviruses, picobirnaviruses, and both viruses, respectively. Partial sequences of the RNA-dependent RNA polymerase gene were determined for three picobirnavirus-positive samples. The sequence identity among these three strains was 60% to 65% for the nucleic acid and 64% to 70% for the deduced amino acid sequences. Phylogenetic analysis revealed that each of the three strains clustered with strains identified in geographically separate areas. In contrast, human calicivirus strains co-incidentally identified, showed complete nucleotide sequence identity. These findings demonstrate a lack of common exposure to or point of source for picobirnavirus infection, suggesting that the outbreak was caused by human caliciviruses. Further studies are needed to determine the etiologic role and to establish the taxonomic basis of picobirnaviruses.
KW - amino acid sequences
KW - epidemiology
KW - faeces
KW - gastroenteritis
KW - heterogeneity
KW - human diseases
KW - outbreaks
KW - phylogenetics
KW - strains
KW - Hungary
KW - man
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - feces
KW - picobirnaviruses
KW - protein sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033217629&site=ehost-live&scope=site
UR - email: gszucs@main.antszbar.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HLA-DPB1 and chronic beryllium disease: a HuGE review.
AU - McCanlies, E. C.
AU - Kreiss, K.
AU - Andrew, M.
AU - Weston, A.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2003///
VL - 157
IS - 5
SP - 388
EP - 398
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - McCanlies, E. C.: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS-L4020, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20033066894. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated a glutamic acid residue at position 69 (HLA-DPB1Glu69) in chronic beryllium disease. This finding has since been extended to specific HLA-DPB1Glu69 alleles. Specific job tasks have also been implicated in degree of risk, and in this paper the authors explore gene-environment interaction. The utility of this genetic information for prospective, current, and former beryllium workers must be weighed against the potential for employment and insurance discrimination. Continued research in the beryllium-exposed population will be important for improving personal risk assessment and identifying high-risk genes associated with disease progression.
KW - berylliosis
KW - beryllium
KW - genotype environment interaction
KW - histocompatibility antigens
KW - human diseases
KW - molecular biology
KW - molecular genetics
KW - occupational hazards
KW - occupational health
KW - reviews
KW - toxic substances
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - human leukocyte antigen
KW - poisons
KW - Occupational Health and Safety (VV900)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033066894&site=ehost-live&scope=site
UR - email: eim4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection.
AU - Verthelyi, D.
AU - Gursel, M.
AU - Kenney, R. T.
AU - Lifson, J. D.
AU - Liu, S. Y.
AU - Mican, J.
AU - Klinman, D. M.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2003///
VL - 170
IS - 9
SP - 4717
EP - 4723
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Verthelyi, D.: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033081618. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Protozoology
N2 - Oligodeoxynucleotides containing CpG motifs (CpG ODNs) mimic microbial DNA and activate effectors of the innate immune response, which limits the spread of pathogens and promotes an adaptive immune response. CpG ODNs have been shown to protect mice from infection with intracellular pathogens. Unfortunately, CpG motifs that optimally stimulate humans are only weakly active in mice, mandating the use of nonhuman primates to monitor the activity and safety of "human" CpG ODNs in vivo. This study demonstrates that CpG ODN treatment of rhesus macaques significantly reduces the severity of the lesions caused by a challenge with Leishmania. Leishmania superinfection is common in immunocompromised hosts, particularly those infected with HIV. This study shows that PBMCs from HIV-infected subjects respond to stimulation with CpG ODNs. To determine whether CpG ODNs can protect retrovirus-infected primates, SIV-infected macaques were treated with CpG ODNs and then challenged with Leishmania. Both lesion size and parasite load were significantly reduced in the CpG-treated animals. These findings support the clinical development of CpG ODNs as immunoprotective agents in normal and HIV-infected patients.
KW - animal models
KW - immunocompromised hosts
KW - immunotherapy
KW - laboratory animals
KW - oligonucleotides
KW - Leishmania
KW - Macaca
KW - simian immunodeficiency virus
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - macaques
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033081618&site=ehost-live&scope=site
UR - email: Verthelyi@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variations in metabolism of the soy isoflavonoid daidzein by human intestinal microfloras from different individuals.
AU - Rafii, F.
AU - Davis, C.
AU - Park, M.
AU - Heinze, T. M.
AU - Beger, R. D.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2003///
VL - 180
IS - 1
SP - 11
EP - 16
CY - Berlin; Germany
PB - Springer-Verlag
SN - 0302-8933
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033147078. Publication Type: Journal Article. Language: English. Registry Number: 486-66-8. Subject Subsets: Human Nutrition; Soyabeans
N2 - Isoflavonoids found in legumes, such as soybeans, are converted by intestinal bacteria to metabolites that might have increased or decreased estrogenic activity. Variation in the effects of dietary isoflavonoids among individuals has been attributed to differences in their metabolism by intestinal bacteria. To investigate this variation, the metabolism of the isoflavonoid daidzein by bacteria from ten faecal samples, provided at different times by six individuals on soy-containing diets, was compared. After anaerobic incubation of bacteria with daidzein for 2 weeks, four samples had metabolized daidzein and six samples had not. Three of the positive samples were from individuals whose microflora had not metabolized daidzein in previous samples. Dihydrodaidzein was observed in one sample, dihydrodaidzein and equol in another sample, and equol and O-desmethylangolensin in two other samples. These results corroborate the hypothesis that the microflora of the gastrointestinal tract of an individual influences the particular isoflavone metabolites produced following consumption.
KW - daidzein
KW - enzyme activity
KW - isoflavonoids
KW - legumes
KW - metabolism
KW - microbial flora
KW - oestrogens
KW - soyabeans
KW - Fabaceae
KW - Glycine (Fabaceae)
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - equol
KW - estrogens
KW - microflora
KW - soybeans
KW - Crop Produce (QQ050)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033147078&site=ehost-live&scope=site
UR - http://www.springerlink.com/app/home/contribution.asp?wasp=99a0hcpuuj2qxke79trn&referrer=parent&backto=issue,2,10;journal,4,113;linkingpublicationresults,id:100459,1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preliminary studies of offspring exposure to phenylbutazone and ivermectin during the perinatal period in a Holstein cow-calf model.
AU - Chamberlain, P. L.
AU - Fowler, B. A.
AU - Sexton, M. J.
AU - Peggins J. O.
AU - Bredow, J. von
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2003///
VL - 187
IS - 3
SP - 198
EP - 208
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Chamberlain, P. L.: Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20033105848. Publication Type: Journal Article. Language: English. Registry Number: 70288-86-7, 50-33-9.
N2 - The pregnant Holstein cow and her newborn calf were evaluated as an animal model to study in utero and for lactational drug transfer and offspring exposure. A nonsteroidal antiinflammatory drug, phenylbutazone, and an antiparasitic drug, ivermectin, were tested in the model. Prior to parturition, pregnant cows were dosed orally to steady state with phenylbutazone at 4 g/day or given a single subcutaneous injection of 200 µg ivermectin/kg body wt. The level of drug transferred to calves exposed in utero, in utero combined with lactational exposure, and via lactational exposure only, was measured from days 1 through 7 postpartum. At birth the plasma level in phenylbutazone-exposed calves was approximately one-half the dam's steady-state level. For ivermectin-exposed calves, plasma levels were at or below the limit of quantitation (0.5 ng/ml) at birth, suggesting that placental transfer of ivermectin is limited in the cow. For both drugs, rapid accumulation of the drug in calf plasma occurred with lactational exposure to a mean daily dose of 2 µg ivermectin/kg body wt or 0.1 mg phenylbutazone/kg body wt/day for the first 7 days of life. The accumulation observed in the newborn calf is attributed to the lipid solubility and long elimination half-lives of these drugs. These results demonstrate that drug transfer and offspring exposure can be studied using the cow-calf model. The data also highlight the importance of considering not only the dose but also physicochemical characteristics and pharmacokinetics of the drug in the offspring when evaluating the safety of a newborn's exposure to a drug in breast milk.
KW - animal models
KW - blood plasma
KW - calves
KW - cows
KW - ivermectin
KW - parturition
KW - phenylbutazone
KW - cattle
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - plasma (blood)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033105848&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-48301FX-B&_user=10&_handle=W-WA-A-A-AW-MsSAYVA-UUW-AUZUYBZZZA-AYZDYVACA-AW-U&_fmt=summary&_coverDate=03%2F15%2F2003&_rdoc=7&_orig=browse&_srch=%23toc%237159%232003%23998129996%23407484!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5c074c74bc5c687e365fa5b2690e91a1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Porin variation among clinical isolates of Neisseria gonorrhoeae over a 10-year period, as determined by por variable region typing.
AU - McKnew, D. L.
AU - Lynn, F.
AU - Zenilman, J. M.
AU - Bash, M. C.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2003///
VL - 187
IS - 8
SP - 1213
EP - 1222
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - McKnew, D. L.: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
N1 - Accession Number: 20033090402. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - The Neisseria gonorrhoeae porin protein (Por) is a potential vaccine target and is the antigenic determinant for serovar typing. Two classes of Por, PIA and PIB, and antigenically distinct variants within each class result from sequence variations in the por gene variable regions (VRs) encoding surface-exposed loops. Oligonucleotide probes to 5 VRs of each class were used in checkerboard hybridizations to type 282 clinical gonococcal isolates selected from strains collected over the course of 10 years. PIA strains (n=63) showed limited por diversity, with 90% having 1 of 4 por types. PIB strains (n=219) were more diverse, although several common por types were identified that persisted over time. Variation within individual VRs was found to be limited. The present study provides information about the diversity of Por in strains circulating in a single geographic region over time, illustrates the utility of a novel por typing method, and has implications for vaccine development.
KW - bacterial diseases
KW - bacterial meningitis
KW - bacterial proteins
KW - genes
KW - genetic variation
KW - human diseases
KW - strains
KW - vaccine development
KW - Maryland
KW - USA
KW - man
KW - Neisseria gonorrhoeae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - porins
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033090402&site=ehost-live&scope=site
UR - email: bash@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays.
AU - Leakey, J. E. A.
AU - Seng, J. E.
AU - Allaben, W. T.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2003///
VL - 193
IS - 2
SP - 237
EP - 265
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Leakey, J. E. A.: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043047079. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - In B6C3F1 mice, the rate of body growth influences susceptibility to liver neoplasia and large variations in body weight can complicate the interpretation of bioassay data. The relationship between body weight and liver tumor incidence was calculated for historical control populations of male and female ad libitum-fed mice (approx. 2750 and 2300 animals, respectively) and in populations of male and female mice which had been subjected to forced body weight reduction due to either dietary restriction or exposure to noncarcinogenic chemicals (approx. 1600 and 1700, respectively). Resulting tumor risk data were then used to construct idealized weight curves for male and female B6C3F1 mice; these curves predict a terminal background liver tumor incidence of 15-20%. Use of dietary control to manipulate body growth of male B6C3F1 mice to fit the idealized weight curve was evaluated in a 2-year bioassay of chloral hydrate. Cohorts of mice were successfully maintained at weights approximating their idealized target weights throughout the study. These mice exhibited less body weight variation than their ad libitum-fed counterparts (e.g., standard deviations of body weight were 1.4 and 3.4 g for respective control groups at 36 weeks). Historical control body weight and tumor risk data from the two male mouse populations were utilized to predict background liver tumor rates for each experimental group of the chloral hydrate study. The predicted background tumor rates closely matched the observed rates for both the dietary controlled and ad libitum-fed chloral hydrate control groups when each mouse was evaluated according to either its weekly food consumption or its weekly change in body weight.
KW - animal models
KW - body weight
KW - diets
KW - growth
KW - laboratory animals
KW - neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043047079&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-49WMWCV-3&_user=10&_handle=B-WA-A-A-AD-MsSAYVA-UUA-AUYBWWCADD-AUYUYUCEDD-BBUEUEWUU-AD-U&_fmt=summary&_coverDate=12%2F01%2F2003&_rdoc=11&_orig=browse&_srch=%23toc%237159%232003%23998069997%23472278!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3cba1cbaf3037281de1f85ea9f499c09
UR - email: jleakey@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice.
AU - Leakey, J. E. A.
AU - Seng, J. E.
AU - Latendresse, J. R.
AU - Hussain, N.
AU - Allen, L. J.
AU - Allaben, W. T.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2003///
VL - 193
IS - 2
SP - 266
EP - 280
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Leakey, J. E. A.: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043047080. Publication Type: Journal Article. Language: English. Registry Number: 302-17-0. Subject Subsets: Human Nutrition
N2 - Chloral hydrate, which is used as a sedative in pediatric medicine and is a by-product of water chlorination, is hepatocarcinogenic in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which are associated with increased body weight. In this study, dietary control was used to manipulate body growth in male B6C3F1 mice in a 2-year bioassay of chloral hydrate. Male B6C3F1 mice were treated with water or 25, 50, or 100 mg/kg chloral hydrate by gavage. The study compared ad libitum-fed mice with dietary controlled mice. The latter received variably restricted feed allocations to maintain their body weights on a predetermined "idealized" weight curve predictive of a terminal background liver tumor incidence of 15-20%. These mice exhibited less individual body weight variation than did their ad libitum-fed counterparts. This was associated with a decreased variation in liver to body weight ratios, which allowed the demonstration of a statistically significant dose response to chloral hydrate in the dietary controlled, but not the ad libitum-fed, test groups. Chloral hydrate increased terminally adjusted liver tumor incidence in both dietary controlled (23.4, 23.9, 29.7, and 38.6% for the four dose groups, respectively) and ad libitum-fed mice (33.4, 52.6, 50.6, and 46.2%), but a statistically significant dose response was observed only in the dietary controlled mice. This dose response positively correlated with markers of peroxisomal proliferation in the dietary controlled mice only. The study suggests that dietary control not only improves terminal survival and decreases interassay variation, but also can increase assay sensitivity by decreasing intra-assay variation.
KW - animal models
KW - body weight
KW - carcinogens
KW - chloral hydrate
KW - diets
KW - drug toxicity
KW - laboratory animals
KW - liver
KW - neoplasms
KW - neuroleptics
KW - toxicology
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - sedatives
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043047080&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-49WMWCV-1&_user=10&_handle=B-WA-A-A-AD-MsSAYVA-UUA-AUYBWWCADD-AUYUYUCEDD-BBUEUEWUU-AD-U&_fmt=summary&_coverDate=12%2F01%2F2003&_rdoc=12&_orig=browse&_srch=%23toc%237159%232003%23998069997%23472278!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6c3f6fa94ac060c19440e71569f9a3fc
UR - email: jleakey@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure.
AU - Seng, J. E.
AU - Agrawal, N.
AU - Horsley, E. T. M.
AU - Leakey, T. I.
AU - Scherer, E. M.
AU - Xia, S. J.
AU - Allaben, W. T.
AU - Leakey, J. E. A.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2003///
VL - 193
IS - 2
SP - 281
EP - 292
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Seng, J. E.: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043047081. Publication Type: Journal Article. Language: English. Registry Number: 302-17-0. Subject Subsets: Human Nutrition
N2 - Chloral hydrate is widely used as a sedative in pediatric medicine and is a by-product of water chlorination and a metabolic intermediate in the biotransformation of trichloroethylene. Chloral hydrate and its major metabolite, trichloroacetic acid, induce liver tumors in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which is associated with increased body weight. This report describes the influence of diet and body weight on the acute toxicity, hepatic enzyme response, and toxicokinetics of chloral hydrate as part of a larger study investigating the carcinogenicity of chloral hydrate in ad libitum-fed and dietary controlled mice. Dietary control involves moderate food restriction to maintain the test animals at an idealized body weight. Mice were dosed with chloral hydrate at 0, 50, 100, 250, 500, and 1000 mg/kg daily, 5 days/week, by aqueous gavage for 2 weekly dosing cycles. Three diet groups were used: ad libitum, dietary control, and 40% caloric restriction. Both dietary control and caloric restriction slightly reduced acute toxicity of high doses of chloral hydrate and potentiated the induction of hepatic enzymes associated with peroxisome proliferation. Chloral hydrate toxicokinetics were investigated using blood samples obtained by sequential tail clipping and a microscale gas chromatography technique. It was rapidly cleared from serum within 3 h of dosing. Trichloroacetate was the major metabolite in serum in all three diet groups. Although the area under the curve values for serum trichloroacetate were slightly greater in the dietary controlled and calorically restricted groups than in the ad libitum-fed groups, this increase did not appear to completely account for the potentiation of hepatic enzyme induction by dietary restriction.
KW - animal models
KW - body weight
KW - carcinogens
KW - chloral hydrate
KW - diets
KW - drug toxicity
KW - laboratory animals
KW - liver
KW - neuroleptics
KW - toxicology
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - sedatives
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043047081&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-49WMWCV-2&_user=10&_handle=B-WA-A-A-AD-MsSAYVA-UUA-AUYBWWCADD-AUYUYUCEDD-BBUEUEWUU-AD-U&_fmt=summary&_coverDate=12%2F01%2F2003&_rdoc=13&_orig=browse&_srch=%23toc%237159%232003%23998069997%23472278!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f6d64b24ec8330097e78ce891342382c
UR - email: jleakey@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dietary genistein on cell replication indices in C57BL6 mice.
AU - Morris, S. M.
AU - Akerman, G. S.
AU - Warbritton, A. R.
AU - Patton, R. E.
AU - Doerge, D. R.
AU - Ding, X. H.
AU - Chen, J. J.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2003///
VL - 195
IS - 2
SP - 139
EP - 145
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0304-3835
AD - Morris, S. M.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-120/DGRT/NCTR, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20033126642. Publication Type: Journal Article. Language: English. Registry Number: 446-72-0. Subject Subsets: Human Nutrition
N2 - The phytoestrogen and isoflavone, genistein, inhibited the activity of the DNA synthesis-related enzyme, topoisomerase-II (topo-II), altered cell-cycle traverse and produced cell death in cell culture models. In order to examine the potential effects of genistein on cell replication and cell death in an animal model, 8-week-old C57BL6 mice were fed either a control diet or one containing one of five doses (100-2000 ppm) of genistein for 28 days. At the end of the feeding period, both male and female mice were sacrificed and the serum isoflavone and aglycone levels determined by liquid chromatography with electrospray tandem mass spectrometry (LC-ES/MS/MS). Immunohistochemistry was utilized to measure the cell replication and cell death rates in the small intestine. Total isoflavone concentration increased from below the limits of detection (0.001 µM) in control animals to 0.28 µM in male and 0.54 µM in female mice fed the 2000 ppm diet. A decrease in the percentage of cells in G0 and an increase in the percentage of cells in S-phase, consistent with topo-II-induced S-phase arrest, was found in the duodenum and jejunum of the small intestine. Thus, genistein appears to accumulate to a sufficient level to affect topo-II activity in the small intestine.
KW - animal models
KW - apoptosis
KW - duodenum
KW - genistein
KW - isoflavones
KW - jejunum
KW - laboratory animals
KW - small intestine
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033126642&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-48B5V5M-1&_user=10&_handle=W-WA-A-A-AY-MsSAYWA-UUA-AUZABCECZZ-AEBEYUACC-AY-U&_fmt=summary&_coverDate=06%2F10%2F2003&_rdoc=2&_orig=browse&_srch=%23toc%234992%232003%23998049997%23431264!&_cdi=4992&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=794a4227f0e72846ddce75e4e490a76e
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of chlorogenic acid on hydroxyl radical.
AU - Zang, L. Y.
AU - Cosma, G.
AU - Gardner, H.
AU - Castranova, V.
AU - Vallyathan, V.
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
Y1 - 2003///
VL - 247
IS - 1/2
SP - 205
EP - 210
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0300-8177
AD - Zang, L. Y.: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS 303, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20033106891. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 327-97-9. Subject Subsets: Human Nutrition
N2 - Chlorogenic acid (CGA) is considered to act as an antioxidant. However, the inhibitory effects of CGA on specific radical species are not well understood. Electron spin resonance (ESR) in combination with spin trapping techniques was utilized to detect free radicals. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was used as a spin trapping reagent while the Fenton reaction was used as a source of hydroxyl radical (.OH). We found that CGA scavenges .OH in a dose-dependent manner. The kinetic parameters, IC50 and Vmax, for CGA scavenging of .OH were 110 and 1.27 µM/sec, respectively. The rate constant for the scavenging of .OH by CGA was 7.73×109 M-1 sec-1. Our studies suggest that the antioxidant properties of CGA may involve a direct scavenging effect of CGA on .OH.
KW - antioxidant properties
KW - chlorogenic acid
KW - free radicals
KW - kinetics
KW - anti-oxidant properties
KW - caffeoylquinic acid
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033106891&site=ehost-live&scope=site
UR - email: laz7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An atypical protein disulfide isomerase from the protozoan parasite Leishmania containing a single thioredoxin-like domain.
AU - Padilla, A.
AU - Noiva, R.
AU - Lee, N.
AU - Mohan, K. V. K.
AU - Nakhasi, H. L.
AU - Debrabant, A.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2003///
VL - 278
IS - 3
SP - 1872
EP - 1878
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Padilla, A.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033059912. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Subject Subsets: Protozoology
N2 - In higher eukaryotes, secretory proteins are under the quality control of the endoplasmic reticulum for their proper folding and release into the secretory pathway. One of the proteins involved in the quality control is protein disulfide isomerase, which catalyzes the formation of protein disulfide bonds. As a first step toward understanding the endoplasmic reticulum quality control of secretory proteins in lower eukaryotes, we have isolated a protein disulfide isomerase gene from the protozoan parasite Leishmania donovani. The parasite enzyme shows high sequence homology with homologs from other organisms. However, unlike the four thioredoxin-like domains found in most protein disulfide isomerases, of which two contain an active site, the leishmanial enzyme possesses only one active site present in a single thioredoxin-like domain. When expressed in Escherichia coli, the recombinant parasite enzyme shows both oxidase and isomerase activities. Replacement of the two cysteins with alanines in its active site results in loss of both enzymatic activities. Further, overexpression of the mutated/inactive form of the parasite enzyme in L. donovani significantly reduced their release of secretory acid phosphatases, suggesting that this single thioredoxin-like domain protein disulfide isomerase could play a critical role in the Leishmania secretory pathway.
KW - characterization
KW - genes
KW - identification
KW - isomerases
KW - Leishmania
KW - Leishmania donovani
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Leishmania
KW - gene sequence
KW - thioredoxin
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033059912&site=ehost-live&scope=site
UR - email: debrabanta@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Limitations of monoclonal antibodies for monitoring of fungal aerosols using Penicillium brevicompactum as a model fungus.
AU - Schmechel, D.
AU - Górny, R. L.
AU - Simpson, J. P.
AU - Reponen, T.
AU - Grinshpun, S. A.
AU - Lewis, D. M.
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2003///
VL - 283
IS - 1/2
SP - 235
EP - 245
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0022-1759
AD - Schmechel, D.: Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S H-4218, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043001992. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Soils & Fertilizers; Medical & Veterinary Mycology
N2 - Moulds are ubiquitous in every environment and many species have been recently associated with an increase in opportunistic infections in immunocompromised patients or the exacerbation of asthmatic episodes in allergic patients. The degree of environmental contamination with fungi thus needs to be monitored and in this study we report the development of a monoclonal antibody (mAb)-mediated enzyme-linked immunosorbent assay (ELISA) for the detection of spores of Penicillium brevicompactum in experimental model aerosols. In addition, we have investigated the influence of different parameters of air sampling and sample recovery on ELISA performance. MAbs were produced with standard hybridoma techniques and cross-reactivities were determined against spores of 53 fungal species by indirect ELISA. Standardized experimental fungal aerosols were collected with the Button Personal Inhalable Aerosol Sampler® onto polycarbonate or polytetrafluoroethylene filters (PTFE) and the effects of different extraction buffers and filter agitation methods during sample processing on spore recovery and ELISA detection were investigated. Five mAbs were produced and all of them cross-reacted with several of 31 related Aspergillus, Penicillium and Eurotium species. However, cross-reactivities with 21 non-related fungi were rare. Spores were recovered in much higher numbers from polycarbonate filters (PFs) than from polytetrafluoroethylene filters. Optical densities (ODs) in ELISA were higher for spores collected into carbonate coating buffer (CCB) than phosphate-buffered saline (PBS). Filter bath sonication following filter vortexing had no positive effects on ELISA sensitivity. The cross-reactivity patterns of mAbs suggest that Aspergillus and Penicillium species share multiple antigens. Quantitative ELISA results for fungal aerosols were found to be influenced by differential sample processing and thus method standardization will be essential to maintain the comparability of immunometric monitoring results.
KW - air
KW - air quality
KW - air spora
KW - cross reaction
KW - ELISA
KW - fungal antigens
KW - fungal spores
KW - monitoring
KW - monoclonal antibodies
KW - techniques
KW - Aspergillus
KW - Eurotium
KW - Penicillium brevicompactum
KW - Trichocomaceae
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Penicillium
KW - enzyme linked immunosorbent assay
KW - fungus
KW - Hyphomycetes
KW - surveillance systems
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043001992&site=ehost-live&scope=site
UR - email: dschmechel@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus.
AU - Chang, G. J. J.
AU - Hunt, A. R.
AU - Holmes, D. A.
AU - Springfield, T.
AU - Chiueh, T. S.
AU - Roehrig, J. T.
AU - Gubler, D. J.
JO - Virology
JF - Virology
Y1 - 2003///
VL - 306
IS - 1
SP - 170
EP - 180
CY - Orlando; USA
PB - Academic Press
SN - 0042-6822
AD - Chang, G. J. J.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20033052780. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - We have constructed a series of plasmids encoding premembrane (prM) and envelope (E) protein genes of dengue virus type 2 (DEN-2). These plasmids included an authentic DEN-2 prM-E construct (pCBD2-14-6), and two chimeric constructs, 90% DEN-2 E-10% Japanese encephalitis (JE) virus E (pCB9D2-1J-4-3) and 80% DEN-2 E-20% JE E (pCB8D2-2J-2-9-1). Monoclonal antibody (MAb) reactivity indicated that all three plasmids expressed authentic DEN-2 virus E protein epitopes representative of flavivirus domains 1, 2, and 3. However, only the pCB8D2-2J-2-9-1 construct secreted high levels of prM, M (membrane), and E proteins into the culture fluid of plasmid-transformed COS-1 cells. The major portion of the prM and E proteins expressed by COS-1 cells transformed by pCBD2-14-6 or pCB9D2-4-3 plasmids remained membrane-bound. The results supported the notion that an unidentified membrane retention sequence is located between E-397 and E-436 of DEN-2 virus E protein. Replacing the carboxyl-terminal 20% of DEN-2 E (397-450) with the corresponding JE sequence had no effect on anti-DEN-2 MAb reactivity, indicating that this region is antigenically inert, although it is required for antigen secretion. Plasmid pCBD2-2J-2-9-1, which expressed secreted forms of prM/M and E that have the potential to form subviral particles, was superior to other constructs in stimulating an antibody response. Ninety percent neutralization titers ranging from 1:40 to >1:1000 were observed in seven of nine serum specimens from pCB8D2-2J-2-9-1-immunized mice. Eleven of twelve 2-day-old neonatal mice, derived from a pCB8D2-2J-2-9-1 immunized female mouse, survived intraperitoneal challenge of DEN-2 New Guinea C virus.
KW - animal models
KW - DNA vaccines
KW - envelope proteins
KW - epitopes
KW - gene expression
KW - genes
KW - immune response
KW - immunization
KW - laboratory animals
KW - maternal immunity
KW - molecular genetics
KW - neutralizing antibodies
KW - newborn animals
KW - plasmids
KW - protein synthesis
KW - recombinant DNA
KW - surface proteins
KW - vaccination
KW - viral antigens
KW - dengue 2 virus
KW - Japanese encephalitis virus
KW - mice
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenic determinants
KW - biochemical genetics
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - membrane proteins
KW - newborn immunity
KW - protein biosynthesis
KW - vitelline immunity
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033052780&site=ehost-live&scope=site
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.
AU - Leonard, S. S.
AU - Xia, C.
AU - Jiang, B. H.
AU - Stinefelt, B.
AU - Klandorf, H.
AU - Harris, G. K.
AU - Shi, X. L.
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
Y1 - 2003///
VL - 309
IS - 4
SP - 1017
EP - 1026
CY - Orlando; USA
PB - Academic Press
SN - 0006-291X
AD - Leonard, S. S.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 20033177035. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Registry Number: 501-36-0. Subject Subsets: Human Nutrition
N2 - Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress has been the subject of many recent studies. Resveratrol, found in various natural food products, has been linked to decreased coronary artery disease and preventing cancer development. The present study measured the effect of resveratrol on several different systems involving the hydroxyl, superoxide, metal/enzymatic-induced, and cellular generated radicals. The rate constant for reaction of resveratrol with the hydroxyl radical was determined, and resveratrol was found to be an effective scavenger of hydroxyl, superoxide, and metal-induced radicals as well as showing antioxidant abilities in cells producing ROS. Resveratrol exhibits a protective effect against lipid peroxidation in cell membranes and DNA damage caused by ROS. Resveratrol was also found to have a significant inhibitory effect on the NF-κB signaling pathway after cellular exposure to metal-induced radicals. It was concluded that resveratrol in foods plays an important antioxidant role.
KW - antioxidant properties
KW - free radicals
KW - medicinal properties
KW - oxidative stress
KW - resveratrol
KW - anti-oxidant properties
KW - reactive oxygen intermediates
KW - Crop Produce (QQ050)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033177035&site=ehost-live&scope=site
UR - email: SEL5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of ion-trap liquid chromatography-mass spectrometry to screen and confirm drug residues in aquacultured products.
AU - Turnipseed, S. B.
AU - Roybal, J. E.
AU - Pfenning, A. P.
AU - Kijak, P. J.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2003///
VL - 483
IS - 1/2
SP - 373
EP - 386
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0003-2670
AD - Turnipseed, S. B.: Animal Drugs Research Center, Food and Drug Administration, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20033099576. Publication Type: Journal Article. Language: English. Registry Number: 56-75-7, 85721-33-1, 91296-86-5, 98106-17-3, 93106-60-6. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - Ion-trap liquid chromatography-multiple mass spectrometry (LC-MSn) has been shown to be a valuable tool for the confirmation of animal drug residues. We have taken advantage of this to update several regulatory methods for the confirmation of drug residues in aquacultured products. Here we report two such examples. First, the use of an ion-trap electrospray instrument collecting data-dependent MS2 and MS3 scans to yield structurally significant ions has allowed multi-residue confirmation of fluoroquinolones in salmon tissue. Ciprofloxacin, enrofloxacin, sarafloxacin, and difloxacin residues were positively identified in salmon muscle fortified at 5-80 µg/kg. These residues were also confirmed in extracts from incurred salmon tissue with final drug concentrations ranging from 10 to 40 µg/kg. The second example deals with multi-residue confirmation of phenicols using ion-trap LC-MSn. Comparisons of these methods with related confirmation procedures are discussed, as well as the optimization of MSn parameters to meet confirmation criteria. Initial efforts to use this instrument in conjunction with generic extraction methods to screen multi-class residues in shrimp tissue are also presented.
KW - analytical methods
KW - aquaculture
KW - chloramphenicol
KW - ciprofloxacin
KW - difloxacin
KW - drug residues
KW - enrofloxacin
KW - fish
KW - liquid chromatography
KW - mass spectrometry
KW - methodology
KW - screening
KW - shrimps
KW - techniques
KW - salmon
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - analytical techniques
KW - fluoroquinolone
KW - methods
KW - sarafloxacin
KW - screening tests
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033099576&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-47MJ13Y-C&_user=10&_handle=W-WA-A-A-VE-MsSAYZA-UUW-AUCYBBWDYW-AVBWBVBEZ-VE-U&_fmt=summary&_coverDate=04%2F25%2F2003&_rdoc=42&_orig=browse&_srch=%23toc%235216%232003%23995169998%23421141!&_cdi=5216&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4945a564c0468d328cc561951bf4cb67
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of 2-bromo-3,4,5,6-tetrachloroaniline and its quantification in the color additives D&C Red Nos. 27 and 28 (phloxine B) using solid-phase microextraction and gas chromatograph-mass spectrometry.
AU - Weisz, A.
AU - Andrzejewski, D.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2003///
VL - 1005
IS - 1/2
SP - 143
EP - 153
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Weisz, A.: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Chantilly, VA 20151, USA.
N1 - Accession Number: 20033169602. Publication Type: Journal Article. Language: English.
N2 - The present work describes (a) the identification and characterization of a contaminant, 2-bromo-3,4,5,6-tetrachloroaniline (2BTCA), in the colour additives D&C Red Nos. 27 and 28 (phloxine B) and (b) the determination of the extent and level of 2BTCA contamination in certified lots of these colors. For these purposes, 2BTCA (a compound not previously reported in the literature) and its positional isomer 4-bromo-2,3,5,6-tetrachloroaniline (4BTCA) were synthetically prepared. 4BTCA was used as the internal standard for the quantification of 2BTCA in the colors. Test portions from 35 certified lots of D&C Red Nos. 27 and 28 were analysed for 2BTCA using a solid-phase microextraction-GC-MS method. Those lots were submitted for certification by both domestic (seven) and foreign (four) manufacturers during the past 4 years. Of the test portions analysed, 22 (62.9%) contained 2BTCA in amounts ranging from 0.15 to 435.7 ppm with an average value of ~131.7 ppm. The remaining 13 (37.1%) test portions contained no detectable 2BTCA or less than 0.01 ppm, which is the limit of quantification of the present method. The analyses revealed substantial differences in the level of 2BTCA across lots from the same manufacturer as well as among different manufacturers. The wide range of 2BTCA levels found in the analysed lots suggests that the presence of 2BTCA in D&C Red Nos. 27 and 28 may be avoided or significantly reduced during the manufacturing process. A direct correlation was observed between the presence of 2BTCA and that of 3,4,5,6-tetrachlorophthalic acid in analysed batches of D&C Red Nos. 27 and 28. A chemical pathway that could explain the presence of 2BTCA in these colour additives, and ways to avoid its formation, are also proposed.
KW - analytical methods
KW - characterization
KW - contaminants
KW - food colourants
KW - GC-MS
KW - 2-bromo-3,4,5,6-tetrachloroaniline
KW - analytical techniques
KW - food colorants
KW - gas chromatography-mass spectrometry
KW - solid-phase microextraction
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033169602&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-491B3CX-D&_user=10&_handle=W-WA-A-A-WC-MsSAYZA-UUA-AUZZYUYWCZ-CAADEBCZ-WC-U&_fmt=summary&_coverDate=07%2F11%2F2003&_rdoc=12&_orig=browse&_srch=%23toc%235248%232003%23989949998%23440096!&_cdi=5248&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3244179f93d6e21c93bf549238e6f2cc
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Nutritional and hematological effects of flaxseed.
AU - Babu, U. S.
AU - Wiesenfeld, P. W.
A2 - Thompson, L. U.
A2 - Cunnane, S. C.
T2 - Flaxseed in human nutrition
Y1 - 2003///
IS - Ed.2
CY - Champaign; USA
PB - AOCS Press
SN - 1893997383
AD - Babu, U. S.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043187405. Publication Type: Book chapter. Language: English. Number of References: 152 ref. Registry Number: 57-88-5, 7439-89-6. Subject Subsets: Human Nutrition
N2 - This chapter discusses some of the nutritional and haematological effects of flaxseed, such as iron status, serum and tissue fatty acids including n-3/n-6 ratio, serum cholesterol and triglyceride levels, liver and kidney function, mineral and vitamin status, platelet structure and function, and laxative effects and blood glucose levels.
KW - blood serum
KW - blood sugar
KW - cholesterol
KW - flax
KW - haematology
KW - iron
KW - kidneys
KW - laxatives
KW - linseed
KW - liver
KW - liver function
KW - minerals
KW - nutrition
KW - platelets
KW - polyenoic fatty acids
KW - renal function
KW - seeds
KW - tissues
KW - triacylglycerols
KW - vitamins
KW - Linum usitatissimum
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - blood glucose
KW - blood platelets
KW - flaxseed
KW - glucose in blood
KW - hematology
KW - kidney function
KW - n-3 fatty acids
KW - n-6 fatty acids
KW - polyunsaturated fatty acids
KW - thrombocytes
KW - triglycerides
KW - Crop Produce (QQ050)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043187405&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effect of flaxseed consumption on male and female reproductive function and fetal development.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Wiesenfeld, P. W.
A2 - Thompson, L. U.
A2 - Cunnane, S. C.
T2 - Flaxseed in human nutrition
Y1 - 2003///
IS - Ed.2
CY - Champaign; USA
PB - AOCS Press
SN - 1893997383
AD - Sprando, R. L.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043187417. Publication Type: Book chapter. Language: English. Number of References: 123 ref. Registry Number: 463-40-1. Subject Subsets: Human Nutrition; Dairy Science
N2 - The beneficial and/or adverse effects of nutrient (α-linoleic acid), non-nutrient (including phytoestrogens), and antinutrient (cyanogenic glycosides) components of flaxseed are presented. The association between phytoestrogens, oestrogen receptors, and fetal development is described. An extensive review of studies on reproductive effects of flaxseed consumption is provided. The reviewed animal studies have suggested that the effect of flaxseed on various reproductive indices and sex hormone levels depends on the dose, timing, and duration of exposure. In the female, effects included a lengthened oestrous cycle, changes in the anogenital distance, extended or shortened onset of puberty, ovarian weight changes, and effects on the maturation of the mammary gland. In the male, effects included changes in serum hormone levels and secondary sex organ weight, especially of the prostate.
KW - animal models
KW - antinutritional factors
KW - cyanogenic glycosides
KW - females
KW - fetal development
KW - flax
KW - food composition
KW - linolenic acid
KW - linseed
KW - males
KW - mammary glands
KW - nutritive value
KW - oestrogen receptors
KW - oestrous cycle
KW - ovaries
KW - plant oestrogens
KW - prostate
KW - puberty
KW - reproduction
KW - seeds
KW - sex hormones
KW - Linum usitatissimum
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - alpha-linolenic acid
KW - breeding cycle
KW - estrogen receptors
KW - estrous cycle
KW - flaxseed
KW - nitrilosides
KW - nutritional value
KW - phytoestrogens
KW - plant estrogens
KW - quality for nutrition
KW - reproductive cycle
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Human Reproduction and Development (VV060)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043187417&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Medicinal plants of the world. Volume 1: Chemical constituents, traditional and modern medicinal uses.
AU - Ross, I. A.
A2 - Ross, I. A.
T2 - Medicinal plants of the world. Volume 1: chemical constituents, traditional and modern medicinal uses
Y1 - 2003///
IS - Ed.2
CY - Totowa; USA
PB - Humana Press
SN - 1588292819
AD - Ross, I. A.: Division of Toxicological Research, United States Department of Health and Human Services, Food and Drug Administration, Washington, DC 20201, USA.
N1 - Accession Number: 20033171075. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - This second edition provides details on the traditional medicinal uses, chemical constituents, origin and geographical distribution, pharmacological activities, clinical trials, colour illustrations, Latin names and botanical descriptions of 26 of the most widely used medicinal plants in the world. This universal reference is intended for pharmacists, physicians, medical chemists, toxicologists and phytochemists, as well as readers who have had little or no previous knowledge of medicinal plants.
KW - chemical composition
KW - geographical distribution
KW - medicinal plants
KW - medicinal properties
KW - plant composition
KW - traditional medicines
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Biological Resources (Plant) (PP720)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033171075&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacterial protein toxins.
JO - Bacterial protein toxins
JF - Bacterial protein toxins
Y1 - 2003///
SP - xvi
EP - 348
CY - Washington; USA
PB - ASM Press
SN - 1555812457
AD - U.S. Food and Drug Administration, CBER FDA, Bldg. 29, Rm. 418, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20033144718. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - This concise volume integrates historical experiences and current knowledge of bacterial toxin biosynthesis, structure and function. It is divided into five sections covering the following topics: genetics and regulation of toxin gene expression; toxin translocation across bacterial membrane barriers; toxin delivery into eukaryotic cells; toxin action; and the current status of both the beneficial and harmful uses of bacterial toxins. The chapters also include both written and pictorial representations of major concepts and additional references. This serves as a reference source for current practitioners and new students alike.
KW - bacterial proteins
KW - bacterial toxins
KW - biosynthesis
KW - gene expression
KW - genetics
KW - toxins
KW - translocation
KW - eukaryotes
KW - Toxinology (VV820) (New March 2000)
KW - Physiology and Biochemistry (Wild Animals) (YY400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033144718&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food defect action levels.
AU - Gecan, J. S.
A2 - Hui, Y. H.
A2 - Bruinsma, B. L.
A2 - Gorham, J. R.
A2 - Nip, W. K.
A2 - Tong, P. S.
A2 - Ventresca, P.
T2 - Food plant sanitation
T3 - Food Science and Technology No.120
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824707931
AD - Gecan, J. S.: U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033125918. Publication Type: Book chapter. Note: Food Science and Technology No.120 Language: English. Number of References: 28 ref. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - This chapter provides an overview of the food defect action levels with respect to the Food, Drug and Cosmetic Act, from their earliest beginnings to their future role in the Food and Drug Administration's new enforcement strategy for contamination of foods by animal filth, decomposition, and extraneous matter.
KW - animal wastes
KW - decomposition
KW - defects
KW - food contamination
KW - food legislation
KW - food safety
KW - foreign bodies
KW - infestation
KW - moulds
KW - pests
KW - birds
KW - insects
KW - rodents
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - mammals
KW - food contaminants
KW - livestock wastes
KW - molds
KW - Laws and Regulations (DD500)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033125918&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Hard or sharp foreign objects in food.
AU - Olsen, A. R.
AU - Zimmerman, M. L.
A2 - Hui, Y. H.
A2 - Bruinsma, B. L.
A2 - Gorham, J. R.
A2 - Nip, W. K.
A2 - Tong, P. S.
A2 - Ventresca, P.
T2 - Food plant sanitation
T3 - Food Science and Technology No.120
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824707931
AD - Olsen, A. R.: U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033125915. Publication Type: Book chapter. Note: Food Science and Technology No.120 Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition
N2 - This chapter defines and describes hazardous foreign objects and non-hazardous foreign objects that are found in food. Hazard controls designed to identify hazards, establish controls, and monitor controls, are described. The chapter ends with a description of the US Food and Drug Administration complaint reporting system involving foreign objects in food or drink.
KW - food safety
KW - foreign bodies
KW - health hazards
KW - monitoring
KW - reviews
KW - surveillance systems
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033125915&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Analysis of drug residues in food.
AU - Turnipseed, S. B.
A2 - Hui, Y. H.
A2 - Bruinsma, B. L.
A2 - Gorham, J. R.
A2 - Nip, W. K.
A2 - Tong, P. S.
A2 - Ventresca, P.
T2 - Food plant sanitation
T3 - Food Science and Technology No.120
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824707931
AD - Turnipseed, S. B.: U.S. Food and Drug Administration, Denver, Colorado, USA.
N1 - Accession Number: 20033125919. Publication Type: Book chapter. Note: Food Science and Technology No.120 Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Human Nutrition; Veterinary Science
N2 - A review is presented discussing several types of analytical methods that can be used in screening, determination and confirmation of drug residues in food. An outline of drug residues and the corresponding analytical methods that can detect them is presented.
KW - analytical methods
KW - confirmatory tests
KW - determination
KW - drug residues
KW - food contamination
KW - food safety
KW - reviews
KW - screening
KW - analytical techniques
KW - food contaminants
KW - screening tests
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033125919&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Filth and extraneous material in food.
AU - Zimmerman, M. L.
AU - Olsen, A. R.
AU - Friedman, S. L.
A2 - Hui, Y. H.
A2 - Bruinsma, B. L.
A2 - Gorham, J. R.
A2 - Nip, W. K.
A2 - Tong, P. S.
A2 - Ventresca, P.
T2 - Food plant sanitation
T3 - Food Science and Technology No.120
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824707931
AD - Zimmerman, M. L.: U.S. Food and Drug Administration, Albuquerque, New Mexico, USA.
N1 - Accession Number: 20033125916. Publication Type: Book chapter. Note: Food Science and Technology No.120 Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - The chapter defines filth and extraneous material in food and categorizes them as potentially hazardous, unsanitary, and aesthetically defective. A flow chart for evaluating types of filth and extraneous material used by the Food and Drug Administration is described.
KW - food contamination
KW - food hygiene
KW - food safety
KW - hazards
KW - food contaminants
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033125916&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Radionuclides in foods: American perspectives.
AU - Baratta, E. J.
A2 - D'Mello, J. P. F.
T2 - Food safety: contaminants and toxins
Y1 - 2003///
CY - Wallingford; UK
PB - CABI Publishing
SN - 0851996078
AD - Baratta, E. J.: Winchester Engineering and Analytical Center, US Food and Drug Administration, 109 Holton Street, Winchester, MA 01890, USA.
N1 - Accession Number: 20033074705. Publication Type: Book chapter. Language: English. Number of References: 38 ref. Registry Number: 7440-39-3, 7440-46-2, 7440-45-1, 7553-56-2, 7439-91-0, 7440-03-1, 7440-18-8, 7440-24-6, 7440-67-7. Subject Subsets: Veterinary Science; Human Nutrition; Veterinary Science; Public Health
N2 - This chapter discusses the nature (atomic structure and isotopes), radioactivity, distribution in the food chain, metabolism, monitoring, toxicity and effects of α radiation, β radiation, γ radiation, 89Sr, 131I, 140Ba, 140La, 137Cs, 90Sr, 134Cs, 65Zn, 95Zr, 95Nb, 103Ru, 106Ru, 140Ce and 141Ce. Risk assessment (radiation protection) and regulatory issues concerning these radionuclides are also discussed.
KW - alpha radiation
KW - barium
KW - beta radiation
KW - caesium
KW - cerium
KW - exposure
KW - food contamination
KW - food safety
KW - foods
KW - gamma radiation
KW - health hazards
KW - iodine
KW - lanthanum
KW - metabolism
KW - niobium
KW - radiation
KW - radioactivity
KW - radionuclides
KW - risk assessment
KW - ruthenium
KW - strontium
KW - zirconium
KW - animals
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - beta rays
KW - cesium
KW - food contaminants
KW - gamma rays
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033074705&site=ehost-live&scope=site
UR - http://www.cabi.org/CABeBooks/default.aspx?site=107&page=45&LoadModule=PDFHier&BookID=157
UR - email: EBARATTA@ORA.FDA.GOV
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Staphylococcus aureus.
AU - Bennett, R. W.
AU - Monday, S. R.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Bennett, R. W.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20033143932. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 64 ref. Subject Subsets: Public Health
N2 - This chapter discusses the characteristics, isolation and identification of S. aureus and staphylococcal enterotoxins; the nature and epidemiology of staphylococcal food poisoning; toxicological activity of enterotoxins; genetic factors involved in virulence; and control measures for reducing the bacterial load in foods.
KW - bacterial diseases
KW - disease prevalence
KW - disease transmission
KW - enterotoxins
KW - epidemiology
KW - food contamination
KW - food poisoning
KW - foodborne diseases
KW - genetic factors
KW - human diseases
KW - microbial contamination
KW - reviews
KW - toxins
KW - virulence
KW - Staphylococcus aureus
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143932&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vibrio vulnificus.
AU - Clergé, G.
AU - Eribo, B. E.
AU - Tall, B. D.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Clergé, G.: U.S. Food and Drug Administration, Howard University, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033143957. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 299 ref. Subject Subsets: Public Health
N2 - This chapter discusses the characteristics, pathogenicity, genetic factors involved in virulence, isolation and identification of V. vulnificus, a gram-negative bacterium that is considered to be one of the most virulent bacterial pathogens known. Epidemiology, modes of infection (septicemia, wound infections, gastroenteritis), and control measures to prevent seafoodborne disease caused by V. vulnificus are also discussed.
KW - bacterial diseases
KW - disease prevalence
KW - disease transmission
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - gastroenteritis
KW - genetic factors
KW - human diseases
KW - microbial contamination
KW - pathogenicity
KW - reviews
KW - seafoods
KW - septicaemia
KW - virulence
KW - Vibrio vulnificus
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - blood poisoning
KW - food contaminants
KW - septicemia
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143957&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The Office International des Epizooties. Part II.
AU - Crawford, L.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Crawford, L.: U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20033144009. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 5 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - The second part of an overview discussing the organizational structure of the World Organization for Animal Health, or the Office International des Epizooties, the international standard-setting organization that deals with animal health issues, including zoonotic diseases, is presented.
KW - animal diseases
KW - animal health
KW - human diseases
KW - infectious diseases
KW - international organizations
KW - zoonoses
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - zoonotic infections
KW - Agencies and Organizations (DD100)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033144009&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Listeria monocytogenes.
AU - Datta, A. R.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Datta, A. R.: U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20033143924. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 95 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - The morphological, taxonomic and genomic characteristics, the life cycle of L. monocytogenes, and detection modalities are described. The pathogenesis, epidemiology and control of foodborne listeriosis are discussed.
KW - detection
KW - disease control
KW - epidemiology
KW - foodborne diseases
KW - genetics
KW - human diseases
KW - life cycle
KW - listeriosis
KW - morphology
KW - pathogenesis
KW - taxonomy
KW - Listeria monocytogenes
KW - man
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - listerellosis
KW - systematics
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Morphology of Microorganisms (ZZ392) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143924&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Nontyphoid Salmonella.
AU - Hanes, D.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Hanes, D.: U.S. Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20033143926. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - This chapter discusses the characteristics of Salmonella sp.; diseases caused by this pathogen (gastroenteritis, bacteremia, enteric or paratyphoid fever, local infections); foodborne transmission, pathogenicity, isolation and identification of Salmonella; genetic factors involved in virulence; and control measures to reduce the incidence of salmonellosis.
KW - bacteraemia
KW - bacterial diseases
KW - disease prevalence
KW - disease transmission
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - gastroenteritis
KW - genetic factors
KW - human diseases
KW - microbial contamination
KW - pathogenicity
KW - reviews
KW - salmonellosis
KW - typhoid
KW - virulence
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacteremia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - Salmonella infections
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143926&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Hazard Analysis and Critical Control Point systems.
AU - Hoskin, G. P.
AU - Jones, W. R.
AU - Podoski, B.
AU - Bluhm, L.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Hoskin, G. P.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20033144011. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 5 ref.
N2 - This chapter summarizes the adoption of HACCP (Hazard Analysis and Critical Control Point) system by the Food and Drug Administration as a mandatory requirement for seafood imported to or produced in the United States. The intent and operation of seafood HACCP requirements (sanitation, hazard identification, control of bacteria) from both user and regulator points of view are described.
KW - critical control points
KW - food contamination
KW - food safety
KW - HACCP
KW - health hazards
KW - microbial contamination
KW - regulations
KW - reviews
KW - sanitation
KW - seafoods
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - hazard analysis critical control points
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033144011&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Typhoid Salmonella.
AU - Hu, L.
AU - Kopecko, D. J.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Hu, L.: U.S. Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20033143928. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 81 ref. Subject Subsets: Public Health
N2 - A brief overview of the characteristics of Salmonella typhi is given. The epidemiology (including foodborne and waterborne outbreaks), clinical characteristics, diagnosis, pathogenesis, and control (including antibiotic treatment, vaccination and disease prevention) of typhoid are discussed.
KW - antibacterial agents
KW - antibiotics
KW - diagnosis
KW - disease control
KW - drug therapy
KW - epidemiology
KW - foodborne diseases
KW - human diseases
KW - immunization
KW - outbreaks
KW - pathogenesis
KW - typhoid
KW - vaccination
KW - waterborne diseases
KW - man
KW - Salmonella typhi
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - chemotherapy
KW - immune sensitization
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143928&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Campylobacter species.
AU - Hu, L.
AU - Kopecko, D. J.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Hu, L.: U.S. Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20033143930. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - A brief overview of the nomenclature, typing, growth and virulence characteristics of Campylobacter sp. is given. The pathogenesis, epidemiology, diagnosis, pathogenesis and control (drug therapy, vaccination and prevention) of campylobacteriosis are discussed.
KW - antibacterial agents
KW - campylobacteriosis
KW - clinical aspects
KW - diagnosis
KW - disease control
KW - disease prevention
KW - drug therapy
KW - epidemiology
KW - foodborne diseases
KW - growth
KW - human diseases
KW - immunization
KW - nomenclature
KW - pathogenesis
KW - taxonomy
KW - vaccination
KW - virulence
KW - Campylobacter
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - immune sensitization
KW - systematics
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143930&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Other Vibrio species.
AU - Kothary, M. H.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Kothary, M. H.: U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033143958. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 211 ref. Subject Subsets: Public Health
N2 - This chapter discusses the characteristics, pathogenicity, genetic factors involved in virulence, isolation and identification of Vibrio mimicus, V. fluvialis, V. furnissii, V. hollisae, V. alginolyticus, V. damsela, V. metschnikovii, V. cincinnatiensis and V. carchariae. The diseases caused by these pathogens, foodborne (seafoods) and non-foodborne transmission of Vibrio infections, and control measures for minimizing the numbers of Vibrio are also discussed.
KW - bacterial diseases
KW - disease prevalence
KW - disease transmission
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - genetic factors
KW - human diseases
KW - microbial contamination
KW - pathogenicity
KW - reviews
KW - seafoods
KW - virulence
KW - Grimontia hollisae
KW - Photobacterium damselae
KW - Vibrio
KW - Vibrio alginolyticus
KW - Vibrio cincinnatiensis
KW - Vibrio fluvialis
KW - Vibrio furnissii
KW - Vibrio harveyi
KW - Vibrio metschnikovii
KW - Vibrio mimicus
KW - Grimontia
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Photobacterium
KW - Vibrio
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - Vibrio carchariae
KW - Vibrio damsela
KW - vibrio hollisae
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143958&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Shigella species.
AU - Lampel, K. A.
AU - Maurelli, A. T.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Lampel, K. A.: U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033143929. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 78 ref. Subject Subsets: Public Health
N2 - The clinical presentation, epidemiology, diagnosis, pathogenesis and control of shigellosis are discussed.
KW - clinical aspects
KW - diagnosis
KW - disease control
KW - epidemiology
KW - foodborne diseases
KW - human diseases
KW - pathogenesis
KW - shigellosis
KW - man
KW - Shigella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - clinical picture
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033143929&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - International handbook of foodborne pathogens.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20033143896. Publication Type: Book. Note: Food Science and Technology, 125 Language: English. Number of References: many ref. Subject Subsets: Public Health; Human Nutrition; Helminthology
N2 - This book serves as a reference for food microbiologists, public health professionals, food scientists and biological science students interested in food safety. Current information on the identification and characterization of foodborne illnesses caused by bacterial, protozoal, viral, prion and helminth pathogens are provided. Part I of the book characterizes the pathogens and discusses the clinical presentation, epidemiology, diagnosis, pathogenesis, and control of foodborne infections. Part II provides a geographic summary. Part II describes microbial risk assessment, reviews the hazard analysis and critical point approach to providing a safe food supply and discusses the role of international bodies in attaining such a goal.
KW - bacterial diseases
KW - clinical aspects
KW - diagnosis
KW - disease control
KW - epidemiology
KW - foodborne diseases
KW - helminthoses
KW - helminths
KW - human diseases
KW - prion diseases
KW - prions
KW - risk assessment
KW - viral diseases
KW - bacteria
KW - man
KW - viruses
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - clinical picture
KW - parasitic worms
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The role of Codex Alimentarius in international standards setting.
AU - Wehr, H. M.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Wehr, H. M.: U.S. Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20033144007. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 14 ref.
N2 - This chapter describes the history and organization of Codex, why it has become increasingly important, and how it develops and adopts food safety and quality standards. The policies that Codex has established to undertake its scientific standards-setting activities are described, as well as the proposed Codex principles for risk analysis and its components (risk assessment, management and communication). The work of Codex in the field of food hygiene is outlined, the types of food hygiene codes of practice and other food hygiene texts that are developed by Codex are reviewed, and the work of Codex Committee on Food Hygiene (CCFH) in the fields of microbiological risk assessment and risk management is discussed.
KW - code of practice
KW - Codex Alimentarius
KW - food hygiene
KW - food quality
KW - food safety
KW - microbiology
KW - quality standards
KW - reviews
KW - risk assessment
KW - standards
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Microbiology (General) (ZZ390)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Major fungal toxins of regulatory concern.
AU - Wood, G. E.
AU - Trucksess, M. W.
AU - Henry, S. H.
A2 - Miliotis, M. D.
A2 - Bier, J. W.
T2 - International handbook of foodborne pathogens
T3 - Food Science and Technology, 125
Y1 - 2003///
CY - New York; USA
PB - Marcel Dekker, Inc.
SN - 0824706854
AD - Wood, G. E.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20033143965. Publication Type: Book chapter. Note: Food Science and Technology, 125 Language: English. Number of References: 127 ref. Registry Number: 149-29-1, 51481-10-8, 17924-92-4. Subject Subsets: Plant Pathology
N2 - This chapter provides an overview of the major mycotoxins that are of significant public health concern at the national and international levels. The mycotoxins that are of current regulatory concern include the aflatoxins, ochratoxin A, deoxynivalenol, fumonisins, patulin, and zearalenone. The occurrence of these toxins and the fungal genera (including Aspergillus and Fusarium), toxicity, analytical methods and regulatory control measures associated with these toxins are presented.
KW - aflatoxins
KW - analytical methods
KW - fumonisins
KW - mycotoxins
KW - occurrence
KW - ochratoxins
KW - patulin
KW - public health
KW - regulation
KW - toxicity
KW - vomitoxin
KW - zearalenone
KW - Aspergillus
KW - Fusarium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - analytical techniques
KW - deoxynivalenol
KW - f-2 toxin
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - Laws and Regulations (DD500)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Characterizing the risk of antimicrobial use in food animals: fluoroquinolone-resistant Campylobacter from consumption of chicken.
AU - Bartholomew, M. J.
AU - Hollinger, K.
AU - Vose, D.
A2 - Torrence, M. E.
A2 - Isaacson, R. E.
T2 - Microbial food safety in animal agriculture: current topics
Y1 - 2003///
CY - Ames; USA
PB - Iowa State Press
SN - 0813814952
AD - Bartholomew, M. J.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20033174596. Publication Type: Book chapter. Language: English. Number of References: 26 ref. Subject Subsets: Poultry; Public Health
N2 - The CVM risk assessment is an example of an antimicrobial resistance risk assessment. In microbial risk assessments, the object is to provide a scientifically based estimate of the impact of a particular microbial risk and/or an estimate of the effect of specified risk management actions, usually by tracing microbes from their sources through various pathways until ultimately humans are exposed to them. In contrast, antimicrobial resistance risk assessment traces resistance traits. To some extent, doing so may include tracing the bacteria carrying the resistance traits. In the CVM risk assessment, an epidemiological approach was used to estimate the mean number of individuals impacted by fluoroquinolone-resistant campylobacteriosis attributable to chicken consumption. Individuals considered to be impacted were those with campylobacteriosis who had fluoroquinolone-resistant infections, had sought care, and were prescribed a fluoroquinolone antibiotic to treat the infections. In 1998, the mean number (the number of cases that would occur on average if 1998 were to be repeated many times) was estimated to be 8678 between the 5th percentile, 4758, and the 95th percentile, 14 369. This corresponds to a risk of one impacted individual in every 34 945 individuals in the United States. The availability of surveillance data concerning the prevalence of campylobacteriosis, per se, as well as concerning the prevalence of resistance in both humans and in chickens was essential for the CVM risk assessment. This work would not have been possible without the data collection efforts of U.S. government agencies, notably the CDC, the USDA, and the Census Bureau. It was also facilitated by the research findings of numerous academic and foreign government researchers.
KW - antibacterial agents
KW - disease prevalence
KW - drug resistance
KW - epidemiology
KW - human diseases
KW - poultry
KW - quinolones
KW - risk assessment
KW - USA
KW - Campylobacter
KW - fowls
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chickens
KW - domesticated birds
KW - fluoroquinolone
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulatory activities of the U.S. food and drug administration designed to control antimicrobial resistance in foodborne pathogens.
AU - Tollefson, L.
AU - Flynn, W. T.
AU - Headrick, M. L.
A2 - Torrence, M. E.
A2 - Isaacson, R. E.
T2 - Microbial food safety in animal agriculture: current topics
Y1 - 2003///
CY - Ames; USA
PB - Iowa State Press
SN - 0813814952
AD - Tollefson, L.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20033174440. Publication Type: Book chapter. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - Increasing resistance to antimicrobial agents is of growing concern to public health officials worldwide. The focus of concern includes infections acquired in hospitals, community infections acquired in outpatient care settings, and resistant foodborne disease associated with drug use in food-producing animals. The FDA's goal in resolving the public health impact arising from use of antimicrobials in food animals is to ensure that significant human antimicrobial therapies are not compromised or lost while providing for the safe use of antimicrobials in food animals. The FDA's approach to the problem is multipronged and innovative as delineated in the Framework Document (U.S. Food and Drug Administration 1999b). The strategy includes revision of the pre-approval safety assessment for new animal drug applications, use of risk assessment to determine the human health impact resulting from the use of antimicrobials in food animals, and robust monitoring for changes in susceptibilities among foodborne pathogens to drugs that are important in both human and veterinary medicine, research, and risk management. The debate over the impact on human health of antimicrobial drug use in food-producing animals has continued for more than thirty years. The identification and subsequent containment of resistance will help ensure the continued effectiveness of veterinary and human antimicrobial drugs for years to come. The ultimate outcome will be to prolong the efficacy of existing and new antimicrobial drugs that are desperately needed to control both human and animal disease and to minimize the spread of resistant zoonotic pathogens to humans through the food supply.
KW - antibiotics
KW - drug resistance
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - livestock
KW - public health
KW - regulations
KW - risk assessment
KW - rules
KW - Laws and Regulations (DD500)
KW - Pesticide and Drug Resistance (HH410)
KW - Animal Husbandry and Production (LL180) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20033174440&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Human immunodeficiency virus type-1 (HIV-1) Tat protein: mechanisms for activation of host factors and viral pathogenesis.
AU - Devadas, K.
AU - Dhawan, S.
A2 - Pandalai, S. G.
T2 - Recent Research Developments in Biochemistry, Vol. 4, Part I
Y1 - 2003///
CY - Trivandrum; India
PB - Research Signpost
SN - 8127100102
AD - Devadas, K.: Immunopathogenesis Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315), Rockville, MD 20852, USA.
N1 - Accession Number: 20043172411. Publication Type: Book chapter. Language: English. Number of References: 106 ref. Subject Subsets: Public Health
N2 - HIV-1 Tat, an 86 amino acid protein of HIV-1, is required for efficient viral replication and viral gene expression. Tat activates a variety of host factors, some of which play a critical role in the progression of HIV-1 infection. Regulation by Tat involves novel processes that have been recognized in the regulation of cellular genes and, therefore, is a potential target for a therapeutic vaccine. This review describes the diverse array of pathways and molecular mechanisms to elucidate Tat-mediated immune regulation and strategies for designing a multi-epitope therapeutic subunit vaccine for reducing progression of HIV infection.
KW - amino acids
KW - epitopes
KW - gene expression
KW - genes
KW - HIV infections
KW - hosts
KW - human diseases
KW - human immunodeficiency viruses
KW - immune response
KW - immunity
KW - immunization
KW - pathogenesis
KW - reviews
KW - Tat protein
KW - vaccine development
KW - viral diseases
KW - viral proteins
KW - viral replication
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenic determinants
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043172411&site=ehost-live&scope=site
UR - email: dhawan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Dietary flaxseed alters hematological, lipid, immune and reproductive parameters in rats.
AU - Babu, U. S.
AU - Wiesenfeld, P. W.
AU - Sprando, R.
AU - Collins, T. F. X.
AU - Raybourne, R. B.
A2 - Pandalai, S. G.
T2 - Recent research developments in life sciences. Vol. 1. Part II
Y1 - 2003///
CY - Trivandrum; India
PB - Research Signpost
SN - 8127100242
AD - Babu, U. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043128176. Publication Type: Book chapter. Language: English. Number of References: 122 ref. Subject Subsets: Human Nutrition
N2 - This chapter summarizes the findings of a number of studies conducted in our Food and Drug Administration (FDA) laboratories over the past few years addressing the safety of dietary flaxseed (FS). Dietary FS studies were initiated as part of the National Cancer Institute interagency agreement to determine the nutritional safety of FS. It was essential to determine the safety of FS because of its increased human consumption around the world. Flaxseed is incorporated up to 12% by weight in several bakery products sold in the U.S. Our studies assessed the safety of FS in both male and female rats, as well as young and retired breeders and therefore represent a large spectrum of ages. In the first study, weanling male and female rats were fed up to 10% FS by weight, for eight weeks and its impact on serum lipid and tissue fatty acids, mineral and vitamin status, liver and kidney functional indices and some basic functions of lymphocytes and macrophages were assessed. In addition to the studies with moderate amount of dietary FS, one of our recent studies involved multiple-generations and very high levels of dietary FS. This toxicology study assessed the possible adverse impact of FS ranging from 0 to 40% on a number of different parameters including, tissue fatty acid metabolism, splenic lymphocyte functions, fetal development, mating behavior, various endpoints of male and female reproductive functions. The results from these studies showed that serum and liver fatty acids were altered by 5 and 10% FS, in both young and retired breeder rats. Flaxseed or defatted flaxseed meal (FLM) did not adversely affect iron or mineral status. Dietary FS up to 10% did not negatively affect the functions of splenic lymphocytes among young and older male and female rats. However, fatty acid composition and functions of peritoneal macrophages were altered in female weanling rats that were fed 10% FS for 8 weeks. In addition, 40% dietary FS resulted in significant changes in the serum and tissue fatty acid composition, vitamin E status and serum cholesterol levels among pregnant and F1 generation rats. Furthermore, 40% FS resulted in decreased proliferation of splenic lymphocytes among pregnant and F1 generation rats, without any impact on mitogen-induced interleukin-2 production or cell subsets. Furthermore, FS/FLM exposure caused an increase in serum LH levels and cauda epididymal sperm numbers, a slight increase in serum testosterone concentrations and a decrease in prostate weight. However, FS/FLM had no effect on spermatogenesis as assessed by a histomorphometric analysis of testicular tissues. High FS consumption did not affect in utero development of female offspring, but affected postnatal development as seen by increased irregularity of estrous cycles. Some of the data presented in this chapter have been published in peer-reviewed journals or book chapters, however, a portion of the data are being presented for the first time. The views expressed in this chapter are the views of the authors and should not be viewed as an endorsement for flaxseed consumption by the United States Food and Drug Administration.
KW - animal models
KW - blood lipids
KW - diets
KW - fatty acids
KW - flax
KW - haematology
KW - immunity
KW - laboratory animals
KW - linseed
KW - liver
KW - macrophages
KW - reproduction
KW - Linum usitatissimum
KW - rats
KW - Linum
KW - Linaceae
KW - Geraniales
KW - Linales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - hematology
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043128176&site=ehost-live&scope=site
UR - email: usb@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food quality, safety and security.
AU - Carson, L. J.
A2 - Reynnells, R.
T2 - Sharing costs of changes in food animal production: producers, consumers, society and the environment, USDA, Jefferson Auditorium, Washington, DC, USA, 17 September 2003
Y1 - 2003///
CY - Washington; USA
PB - United States Department of Agriculture (USDA)
AD - Carson, L. J.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Department of Health and Human Services, College Park, MD 20740, USA.
N1 - Accession Number: 20063236092. Publication Type: Book chapter; Conference paper. Language: English. Subject Subsets: Animal Breeding
KW - animal production
KW - food hygiene
KW - food production
KW - food quality
KW - food safety
KW - food security
KW - food supply
KW - foodborne diseases
KW - public health
KW - terrorism
KW - Maryland
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063236092&site=ehost-live&scope=site
UR - http://www.cabi.org/cabdirect/showpdf.aspx?PAN=http://www.cabi.org/cabdirect/showpdf.aspx?PAN=20063236092
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - 5′- and 3′-noncoding regions in flavivirus RNA.
AU - Markoff, L.
A2 - Chambers, T. J.
A2 - Monath, T. P.
T2 - The flaviviruses: structure, replication and evolution
T3 - Advances in Virus Research Volume 59
Y1 - 2003///
CY - San Diego; USA
PB - Elsevier Academic Press
SN - 0120398591
AD - Markoff, L.: Laboratory of Vector-borne Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043140890. Publication Type: Book chapter. Note: Advances in Virus Research Volume 59 Language: English. Number of References: many ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology
N2 - This review focuses on the conserved and nucleotide sequence elements of the flavivirus RNA 5′- and 3′-noncoding regions and their function in RNA replication and translation.
KW - nucleotide sequences
KW - replication
KW - reviews
KW - RNA
KW - translation
KW - viral replication
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - DNA sequences
KW - ribonucleic acid
KW - RNA translation
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043140890&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antigenic structure of flavivirus proteins.
AU - Roehrig, J. T.
A2 - Chambers, T. J.
A2 - Monath, T. P.
T2 - The flaviviruses: structure, replication and evolution
T3 - Advances in Virus Research Volume 59
Y1 - 2003///
CY - San Diego; USA
PB - Elsevier Academic Press
SN - 0120398591
AD - Roehrig, J. T.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20043140889. Publication Type: Book chapter. Note: Advances in Virus Research Volume 59 Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Entomology
N2 - This chapter reviews current knowledge of the antigenic fine structure of flaviviral structural and nonstructural proteins and their involvement in B and T lymphocyte host responses.
KW - antigens
KW - B lymphocytes
KW - immune response
KW - reviews
KW - T lymphocytes
KW - viral proteins
KW - viral structural proteins
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - B cells
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - T cells
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Morphology of Microorganisms (ZZ392) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis vaccine development: research, regulatory and clinical strategies.
AU - Brennan, M. J.
AU - Morris, S. L.
AU - Sizemore, C. F.
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
Y1 - 2004///
VL - 4
IS - 9
SP - 1493
EP - 1504
CY - London; UK
PB - Ashley Publications
SN - 1471-2598
AD - Brennan, M. J.: Center for Biologics Evaluation and Research, Laboratory of Mycobacterial Diseases and Cellular Immunology, Food and Drug Administration, Bldg 29 Rm 503 HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073170326. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - In the past decade, while the global tuberculosis (TB) epidemic has continued to devastate mankind, considerable progress has nevertheless been made in the development of new and improved vaccines for this ancient disease. Recombinant bacillus Calmette-Guerin strains, DNA-based vaccines, live attenuated Mycobacterium tuberculosis vaccines and subunit vaccines formulated with novel adjuvants have shown promise in preclinical animal challenge models. Three of these vaccines are being evaluated at present in human clinical studies, and several other vaccine preparations are being targeted for clinical trials in the near future. Although the preclinical characterisation and testing of new TB vaccines has clearly led to exciting new findings, complex regulatory and clinical trial design issues remain as a challenge to TB vaccine development. This report reviews some of the exciting advances in TB research that have led to the development of new TB vaccines, and addresses the unique regulatory and clinical issues associated with the testing of novel anti-TB preparations in human populations.
KW - adjuvants
KW - characterization
KW - clinical trials
KW - epidemics
KW - live vaccines
KW - tuberculosis
KW - vaccine development
KW - vaccines
KW - man
KW - Mycobacterium
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - attenuated vaccines
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073170326&site=ehost-live&scope=site
UR - http://www.expertopin.com/doi/abs/10.1517/14712598.4.9.1493
UR - email: brennan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of wood-dust aerosol size-distributions collected by air samplers.
AU - Harper, M.
AU - Akbar, M. Z.
AU - Andrew, M. E.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2004///
VL - 6
IS - 1
SP - 18
EP - 22
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 1464-0325
AD - Harper, M.: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS-3030 1095 Willowdale Rd, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043023324. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Forest Products
N2 - A method has been described previously for determining particle size distributions in the inhalable size range collected by personal samplers for wood dust. In this method, the particles collected by a sampler are removed, suspended, and redeposited on a mixed cellulose-ester filter, and examined by optical microscopy to determine particle aerodynamic diameters. This method is particularly appropriate to wood-dust particles which are generally large and close to rectangular prisms in shape. The method was used to investigate the differences in total mass found previously in studies of side-by-side sample collection with different sampler types. Over 200 wood-dust samples were collected in three different wood-products industries, using the traditional 37 mm closed-face polystyrene/acrylonitrile cassette (CFC), the Institute of Occupational Medicine (IOM) inhalable sampler, and the Button sampler developed by the University of Cincinnati. Total mass concentration results from the samplers were found to be in approximately the same ratio as those from traditional long-term gravimetric samples, but about an order of magnitude higher. Investigation of the size distributions revealed several differences between the samplers. The wood dust particulate mass appears to be concentrated in the range 10-70 aerodynamic equivalent diameter (AED), but with a substantial mass contribution from particles larger than 100 µm AED in a significant number of samples. These ultra-large particles were found in 65% of the IOM samples, 42% of the CFC samples and 32% of the Button samples. Where present, particles of this size range dominated the total mass collected, contributing an average 53% (range 10-95%). However, significant differences were still found after removal of the ultra-large particles. In general, the IOM and CFC samplers appeared to operate in accordance with previous laboratory studies, such that they both collected similar quantities of particles at the smaller diameters, up to ~30-40 µm AED, after which the CFC collection efficiency was reduced dramatically compared to the IOM. The Button sampler collected significantly less than the IOM at particle sizes between 10.1 and 50 µm AED. The collection efficiency of the Button sampler was significantly different from that of the CFC for particle sizes between 10.1 and 40 µm AED, and the total mass concentration given by the Button sampler was significantly less than that given by the CFC, even in the absence of ultra-large particles. The results are consistent with some relevant laboratory studies.
KW - aerosols
KW - air quality
KW - forest products industries
KW - methodology
KW - particle size distribution
KW - safety at work
KW - wood dust
KW - forest industry
KW - methods
KW - occupational safety
KW - Logging and Wood Processing (KK515)
KW - Occupational Health and Safety (VV900)
KW - Plant Wastes (XX200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatitis B and hepatitis C seroprevalence and risk behaviour among community-recruited drug injectors in North West Wales.
AU - Craine, N.
AU - Walker, A. M.
AU - Williamson, S.
AU - Brown, A.
AU - Hope, V. D.
JO - Communicable Disease and Public Health
JF - Communicable Disease and Public Health
Y1 - 2004///
VL - 7
IS - 3
SP - 216
EP - 219
CY - London; UK
PB - Health Protection Agency
SN - 1462-1843
AD - Craine, N.: National Public Health Service for Wales Microbiology, Ysbyty Gwynedd, Bangor LL55 2PW, UK.
N1 - Accession Number: 20053114483. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - We estimated the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and injecting risk behaviour, among community-recruited injecting drug users (IDUs) in North West Wales, UK during 2001 and 2002. Sample collection was undertaken by trained current and former IDUs. Oral fluid samples (n=153) were tested as part of the Unlinked Anonymous Prevalence Monitoring Programme ongoing survey of IDUs. Approximately 12% of the sample reported that they were currently in a drug treatment programme. Of the 153 samples screened, 27% (95% confidence interval (CI), 20%-34%; 41/153) were anti-HBc positive, and 23% (95% CI, 16%-30%; 35/153) were anti-HCV positive. Sixteen percent (95% CI, 10%-22%; 25/153) of the samples were positive for both anti-HBc and anti-HCV. Of the subjects, 15% (95% CI, 9%-20%) knew they had been vaccinated against hepatitis B. Direct sharing of needles and syringes in the 28 days prior to interview was reported by 44% (95% CI, 35%-54%), and sharing of any equipment including that used for drug preparation prior to injection was reported by 66% (95% CI, 57%-76%). In North West Wales, syringe sharing is a common practice, and a high proportion of IDUs have been exposed to bloodborne viruses. Hepatitis B vaccination coverage within this population appears to be low and needs to be increased. Further efforts are needed to improve the availability of clean injecting equipment.
KW - antibodies
KW - behaviour
KW - disease prevalence
KW - disease surveys
KW - hepatitis B
KW - hepatitis C
KW - human diseases
KW - injecting drug abuse
KW - injecting drug users
KW - liver
KW - liver diseases
KW - mixed infections
KW - needle sharing
KW - risk behaviour
KW - serological surveys
KW - seroprevalence
KW - syringes
KW - UK
KW - Wales
KW - hepatitis B virus
KW - hepatitis C virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - behavior
KW - Britain
KW - disease surveillance
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - multiple infections
KW - risk behavior
KW - seroepidemiology
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053114483&site=ehost-live&scope=site
UR - http://www.phls.co.uk./
UR - email: noel.craine@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a standardized susceptibility test for Campylobacter with quality-control ranges for ciprofloxacin, doxycycline, erythromycin, gentamicin, and meropenem.
AU - McDermott, P. F.
AU - Bodeis, S. M.
AU - Aarestrup, F. M.
AU - Brown, S.
AU - Traczewski, M.
AU - Fedorka-Cray, P.
AU - Wallace, M.
AU - Critchley, I. A.
AU - Thornsberry, C.
AU - Graff, S.
AU - Flamm, R.
AU - Beyer, J.
AU - Shortridge, D.
AU - Piddock, L. J.
AU - Ricci, V.
AU - Johnson, M. M.
AU - Jones, R. N.
AU - Reller, B.
AU - Mirrett, S.
AU - Aldrobi, J.
AU - Rennie, R.
AU - Brosnikoff, C.
AU - Turnbull, L.
AU - Stein, G.
AU - Schooley, S.
AU - Hanson, R. A. (et al)
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
Y1 - 2004///
VL - 10
IS - 2
SP - 124
EP - 131
CY - Larchmont; USA
PB - Mary Ann Liebert, Inc.
SN - 1076-6294
AD - McDermott, P. F.: Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20043161846. Publication Type: Journal Article. Language: English. Registry Number: 85721-33-1, 24390-14-5, 10592-13-9, 564-25-0, 114-07-8, 1403-66-3, 1405-41-0, 96036-03-2, 119478-56-7. Subject Subsets: Public Health
N2 - A standardized agar dilution susceptibility testing method was developed for Campylobacter that consisted of testing on Mueller-Hinton medium supplemented with 5% defibrinated sheep blood in an atmosphere of 10% CO2, 5% O2, and 85% N2. Campylobacter jejuni ATCC 33560 was identified as a quality-control (QC) strain. Minimal inhibitory concentration (MIC) QC ranges were determined for 2 incubation time/temperature combinations: 36°C for 48 h and 42°C for 24 h. Quality-control ranges were determined for ciprofloxacin, doxycycline, erythromycin, gentamicin, and meropenem. For all antimicrobial agents tested at both temperatures, 95-100% of the QC MIC results fell within recommended QC ranges. 21 Campylobacter clinical isolates, encompassing 5 species of Campylobacter (C. jejuni, C. coli, C. jejuni, subsp. doylei, C. fetus, and C. lari) were tested in conjunction with the C. jejuni QC strain. While C. jejuni and C. coli could be reliably tested under both test conditions, growth of C. jejuni subsp. doylei, C. fetus, and C. lari isolates was inconsistent when incubated at 42°C. Therefore, it is recommended that these species only be tested at 36°C.
KW - antibacterial agents
KW - ciprofloxacin
KW - doxycycline
KW - drug resistance
KW - drug susceptibility
KW - erythromycin
KW - gentamicin
KW - human diseases
KW - meropenem
KW - quality controls
KW - Campylobacter coli
KW - Campylobacter fetus
KW - Campylobacter jejuni
KW - Campylobacter jejuni subsp. doylei
KW - Campylobacter lari
KW - man
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Campylobacter jejuni
KW - bacterium
KW - quality assurance
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043161846&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycobacterium bovis infection, United Kingdom.
AU - Smith, R. M. M.
AU - Drobniewski, F.
AU - Gibson, A.
AU - Montague, J. D. E.
AU - Logan, M. N.
AU - Hunt, D.
AU - Hewinson, G.
AU - Salmon, R. L.
AU - O'Neill, B.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004///
VL - 10
IS - 3
SP - 539
EP - 541
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Smith, R. M. M.: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Abton House, Wedal Road, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20043042436. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - The first documented spillover of bovine tuberculosis from animals into the human population, since the resurgence of the disease in cattle in the UK, is described. This finding suggests that there may be a small risk for transmission to humans, making continued vigilance particularly necessary.
KW - cattle diseases
KW - disease transmission
KW - human diseases
KW - tuberculosis
KW - zoonoses
KW - UK
KW - man
KW - Mycobacterium bovis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterium
KW - Britain
KW - United Kingdom
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043042436&site=ehost-live&scope=site
UR - email: robert.smith@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Who uses food label information: a case study of dietary fat.
AU - Lin, C. T. J.
AU - Lee, J. Y.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2004///
VL - 10
IS - 4
SP - 17
EP - 37
CY - Binghamton; USA
PB - Food Products Press
SN - 1045-4446
AD - Lin, C. T. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-727, College Park, MD 20740, USA.
N1 - Accession Number: 20053031953. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - Consumer psychology suggests that fat intake and search for fat information on food labels may be mutually dependent. This study extends previous research by using a simultaneous-equation model to measure the relationship between fat intake among adults (aged ≥20 years) and label use. The 1994-96 USDA CSII and DHKS (USA) data were used, including 3892 observations for analysis. The results showed that individuals who consumed a higher percentage of calories from fat were less likely to report searching for fat information on food labels. The roles played by several psychological variables on information search and fat intake were also identified. It is suggested that these findings have important implications on nutrition education and effectiveness of food labels.
KW - adults
KW - caloric intake
KW - calories
KW - consumer information
KW - dietary fat
KW - fat consumption
KW - food intake
KW - nutrition information
KW - nutrition labeling
KW - psychology
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - psychological factors
KW - source fat
KW - United States of America
KW - Consumer Economics (EE720)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053031953&site=ehost-live&scope=site
UR - email: clin@cfsan.fda.gov\jlee@mail.ifas.ufl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A study of logger fatalities from 1992-2000.
AU - Scott, D. F.
JO - Injury Prevention
JF - Injury Prevention
Y1 - 2004///
VL - 10
IS - 4
SP - 239
EP - 243
CY - London; UK
PB - BMJ Publishing Group
SN - 1353-8047
AD - Scott, D. F.: National Institute for Occupational Safety and Health, Spokane Research Laboratory, Spokane, WA 99207, USA.
N1 - Accession Number: 20043176803. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - Objectives: To determine if certain loggers are at increased risk of death during logging operations in the USA. Methods: Statistical analysis of 780 logger fatalities for a nine year period (1992-2000). Results: The major findings are: (1) treefallers suffer nearly 63% of all fatalities, (2) the region where the fatality occurred and the size of the employer were not significant factors that contributed to a high percentage of treefaller fatalities, and (3) the Northeast and Midwest regions showed a higher percentage of fatalities compared with the South and West regions. Conclusions: Overall, the logger fatality rate for 1992-2000, compared with 1980-88 has decreased slightly; however, treefallers continue to be the group of loggers who suffer the highest fatality rate.
KW - death
KW - epidemiology
KW - logging
KW - mortality
KW - occupational hazards
KW - occupational health
KW - risk assessment
KW - safety at work
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - occupational safety
KW - timber extraction
KW - timber harvesting
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043176803&site=ehost-live&scope=site
UR - http://www.injuryprevention.com
UR - email: dus3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparisons of test statistics arising from marginal analyses of multivariate survival data.
AU - Li, Q. H.
AU - Lagakos, S. W.
JO - Lifetime Data Analysis
JF - Lifetime Data Analysis
Y1 - 2004///
VL - 10
IS - 4
SP - 389
EP - 405
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 1380-7870
AD - Li, Q. H.: Center for Drug Evaluation and Research, Food and Drug Administration, HFD 705, Rockville, MD 20857, USA.
N1 - Accession Number: 20053016691. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - We investigate the properties of several statistical tests for comparing treatment groups with respect to multivariate survival data, based on the marginal analysis approach introduced by Wei, Lin and Weissfeld ["Regression Analysis of multivariate incomplete failure time data by modelling marginal distributions," JASA vol. 84 pp. 1065-1073]. We consider two types of directional tests, based on a constrained maximization and on linear combinations of the unconstrained maximizer of the working likelihood function, and the omnibus test arising from the same working likelihood. The directional tests are members of a larger class of tests, from which an asymptotically optimal test can be found. We compare the asymptotic powers of the tests under general contiguous alternatives for a variety of settings, and also consider the choice of the number of survival times to include in the multivariate outcome. We illustrate the results with simulations and with the results from a clinical trial examining recurring opportunistic infections in persons with HIV.
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - opportunistic infections
KW - simulation
KW - statistical analysis
KW - survival
KW - viral diseases
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - statistical methods
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053016691&site=ehost-live&scope=site
UR - email: liq@cder.fda.gov\lagakos@hsph.harvard.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Environmental and occupational health response to SARS, Taiwan, 2003.
AU - Esswein, E. J.
AU - Kiefer, M.
AU - Wallingford, K.
AU - Burr, G.
AU - Lee JyhunHsiarn [Lee, J. H. L.]
AU - Wang JungDer
AU - Wang ShunChih
AU - Su IhJen
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004///
VL - 10
IS - 7
SP - 1187
EP - 1194
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Esswein, E. J.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Denver Field Office, Denver, CO 80225-0226, USA.
N1 - Accession Number: 20043121027. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - Industrial hygiene specialists from the National Institute for Occupational Safety and Health (NIOSH) visited hospitals and medical centres throughout Taiwan. They assisted with designing and evaluating ventilation modifications for infection control, developed guidelines for converting hospital rooms into SARS patient isolation rooms, prepared designs for the rapid conversion of a vacated military facility into a SARS screening and observation facility, assessed environmental aspects of dedicated SARS hospitals, and worked in concert with the Taiwanese to develop hospital ventilation guidelines. We describe the environmental findings and observations from this response, including the rapid reconfiguration of medical facilities during a national health emergency, and discuss environmental challenges should SARS or a SARS-like virus emerge again.
KW - disease control
KW - guidelines
KW - health care
KW - health care workers
KW - health centres
KW - health services
KW - hospitals
KW - human coronaviruses
KW - human diseases
KW - hygiene
KW - occupational health
KW - respiratory diseases
KW - severe acute respiratory syndrome
KW - ventilation
KW - viral diseases
KW - Taiwan
KW - man
KW - Coronavirus
KW - Coronaviridae
KW - Nidovirales
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - South East Asia
KW - Asia
KW - Formosa
KW - health centers
KW - human coronavirus
KW - lung diseases
KW - recommendations
KW - SARS
KW - SARS coronavirus
KW - viral infections
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043121027&site=ehost-live&scope=site
UR - email: eje1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Q fever outbreak in industrial setting.
AU - Woerden, H. C. van
AU - Mason, B. W.
AU - Nehaul, L. K.
AU - Smith, R.
AU - Salmon, R. L.
AU - Healy, B.
AU - Valappil, M.
AU - Westmoreland, D.
AU - Martin, S. de
AU - Evans, M. R.
AU - Lloyd, G.
AU - Hamilton-Kirkwood, M.
AU - Williams, N. S.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004///
VL - 10
IS - 7
SP - 1282
EP - 1289
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Woerden, H. C. van: National Public Health Service for Wales, Cardiff, UK.
N1 - Accession Number: 20043121041. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - An outbreak of Q fever occurred in South Wales, UK between 15 July and 30 September 2002. To investigate the outbreak, a cohort and nested case-control study was conducted among persons who had worked at a cardboard manufacturing plant. The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. 95 cases of acute Q fever were identified. The epidemic curve and other data suggested an outbreak source likely occurred 5 to 9 August 2002. Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). The offices were undergoing renovation work around the time of likely exposure and contained strawboard that had repeatedly been drilled. The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated strawboard.
KW - aerosols
KW - bacterial spores
KW - contamination
KW - epidemics
KW - epidemiology
KW - exposure
KW - human diseases
KW - outbreaks
KW - Q fever
KW - strawboards
KW - UK
KW - Wales
KW - Coxiella burnetii
KW - man
KW - Coxiella
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - abattoir fever
KW - bacterium
KW - Balkan grippe
KW - Britain
KW - Derrick-Burnet disease
KW - Nine Mile fever
KW - pneumorickettsiosis
KW - quadrilateral fever
KW - query fever
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043121041&site=ehost-live&scope=site
UR - email: vanwoerdenh1@cf.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Space-time cluster analysis of invasive meningococcal disease.
AU - Hoebe, C. J. P. A.
AU - Melker, H. de
AU - Spanjaard, L.
AU - Dankert, J.
AU - Nagelkerke, N.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004///
VL - 10
IS - 9
SP - 1621
EP - 1626
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Hoebe, C. J. P. A.: Department of Infectious Diseases, Eastern South Limburg Municipal Public Health Service, P.O. Box 155, NL-6400 AD Heerlen, Netherlands.
N1 - Accession Number: 20043155967. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Clusters are recognized when meningococcal cases of the same phenotypic strain (markers: serogroup, serotype, and subtype) occur in spatial and temporal proximity. The incidence of such clusters was compared to the incidence that would be expected by chance by using space-time nearest-neighbor analysis of 4887 confirmed invasive meningococcal cases identified in the nine-year surveillance period January 1993-May 2001 in the Netherlands. Clustering beyond chance only occurred among the closest neighboring cases (comparable to secondary cases) and was small (3.1%, 95% confidence interval 2.1%-4.1%).
KW - bacterial diseases
KW - cluster analysis
KW - disease incidence
KW - epidemiology
KW - human diseases
KW - meningococcal disease
KW - phenotypes
KW - serotypes
KW - strains
KW - Netherlands
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Meningococcus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043155967&site=ehost-live&scope=site
UR - email: hoebec@ggdozl.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial drug development - the past, the present, and the future.
AU - Powers, J. H.
T3 - What is Influencing Pharmaceutical Company Decisions to Conduct Anti-Infective Drug Discovery?
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
Y1 - 2004///
VL - 10
SP - 23
EP - 31
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1198-743X
AD - Powers, J. H.: US Food and Drug Administration, 9201 Corporate Blvd., HFD-104 Rockville, MD 20850, USA.
N1 - Accession Number: 20043199482. Publication Type: Journal Article. Note: What is Influencing Pharmaceutical Company Decisions to Conduct Anti-Infective Drug Discovery? Language: English. Number of References: 21 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - Antimicrobial resistance has been an issue since the introduction into clinical use of the first agents in the 1940s. Although the discovery and development of new classes of antimicrobials through the 1960s presented an array of treatment options, these options for some serious and life-threatening infectious diseases may now be more limited. This paper examines the history of antimicrobial development, showing how the challenges in discovering new classes of drugs have been with us for the last 40 years. The present state of antimicrobial discovery and development is shaped by these challenges as well as by the economic realities of the pharmaceutical industry. This paper also discusses some of the regulatory considerations in antimicrobial drug development, and presents some potential solutions to the challenges inherent in antimicrobial drug development, including steps taken by the US Food and Drug Administration to streamline the drug review process for antimicrobial agents while maintaining the standards necessary to protect and promote the health of the public.
KW - antibacterial agents
KW - bacterial diseases
KW - drug development
KW - drug resistance
KW - drug therapy
KW - human diseases
KW - marketing
KW - reviews
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - Marketing and Distribution (EE700)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043199482&site=ehost-live&scope=site
UR - email: POWERSJOH@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of a multiplexed fluorescent covalent microsphere immunoassay and an enzyme-linked immunosorbent assay for measurement of human immunoglobulin G antibodies to anthrax toxins.
AU - Biagini, R. E.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Semenova, V.
AU - Steward-Clark, E.
AU - Stamey, K.
AU - Freeman, A. E.
AU - Quinn, C. P.
AU - Snawder, J. E.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2004///
VL - 11
IS - 1
SP - 50
EP - 55
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Biagini, R. E.: Division of Applied and Technology, Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, CDC/National Institute for Occupational Safety and Health MS C-26, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043018866. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - Recently, the Centers for Disease Control and Prevention reported an accurate, sensitive, specific, reproducible, and quantitative enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) antibodies to Bacillus anthracis protective antigen (PA) in human serum (C. P. Quinn, V. A. Semenova, C. M. Elie et al., Emerg. Infect. Dis. 8:1103-1110, 2002). The ELISA had a minimum detectable concentration (MDC) of 0.06 µg/ml, which, when dilution adjusted, yielded a whole-serum MDC of 3.0 µg of anti-PA IgG per ml. The reliable detection limit (RDL) was 0.09 µg/ml, while the dynamic range was 0.06 to 1.7 µg/ml. The diagnostic sensitivity of the assay was 97.6% and the diagnostic specificity was 94.2% for clinically verified cases of anthrax. A competitive inhibition anti-PA IgG ELISA was also developed to enhance the diagnostic specificity to 100%. We report a newly developed fluorescence covalent microbead immunosorbent assay (FCMIA) for B. anthracis PA which was Luminex xMap technology. The FCMIA MDC was 0.006 µg of anti-PA IgG per ml, the RDL was 0.016 µg/ml, and the whole-serum equivalent MDC was 1.5 µg/ml. The dynamic range was 0.006 to 6.8 µg/ml. Using this system, we analyzed 20 serum samples for anti-PA IgG and compared our results to those measured by ELISA in a double-masked analysis. The two methods had a high positive correlation (r2=0.852; P<0.001). The FCMIA appears to have benefits over the ELISA for the measurement of anti-PA IgG, including greater sensitivity and speed, enhanced dynamic range and reagent stability, the use of smaller sample volumes, and the ability to be multiplexed (measurement of more than one analyte simultaneously), as evidenced by the multiplexed measurement in the present report of anti-PA and anti-lethal factor IgG in serum from a confirmed clinical anthrax infection.
KW - animal diseases
KW - anthrax
KW - ELISA
KW - human diseases
KW - immunofluorescence
KW - zoonoses
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - fluorescent antibody technique
KW - IFAT
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043018866&site=ehost-live&scope=site
UR - email: rbiagini@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular quality of exfoliated cervical cells: implications for molecular epidemiology and biomarker discovery.
AU - Habis, A. H.
AU - Vernon, S. D.
AU - Lee, D. R.
AU - Verma, M.
AU - Unger, E. R.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2004///
VL - 13
IS - 3
SP - 492
EP - 496
CY - Philadelphia; USA
PB - American Association for Cancer Research Inc.
SN - 1055-9965
AD - Habis, A. H.: Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20043199896. Publication Type: Journal Article. Language: English. Registry Number: 63231-63-0. Subject Subsets: Public Health
N2 - The biologic sample collected in molecular epidemiology studies must accurately reflect the disease being studied and have sufficient molecular quality for the intended assays. Noninvasive sampling methods, such as scrapes or brushes, are increasingly used. In this study, we evaluate the impact of sample collection media and extraction methods on the quality and yield of RNA from routine exfoliated cervical cytology. Excess cellular material remaining on the cytologic collection device after preparation of the routine screening Papanicolaou smear was placed in a variety of collection media and extracted using two commercial kits. The collection media had the largest impact on the yield and quality of RNA as evaluated by denaturing agarose gel electrophoresis and image analysis. Two collection media, PAXgene and PreservCyt, yielded RNA from most samples. The RNA showed some degree of degradation as evidenced by the reduced size of the higher molecular weight ribosomal band. However, with a sensitive gold particle-based detection method, reproducible microarray results were obtained using this RNA.
KW - biochemical markers
KW - cervical cancer
KW - cervix
KW - cytology
KW - molecular epidemiology
KW - molecular weight
KW - neoplasms
KW - ribosomes
KW - RNA
KW - biomarkers
KW - cancers
KW - cervical cells
KW - ribonucleic acid
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043199896&site=ehost-live&scope=site
UR - http://cebp.aacrjournals.org/cgi/content/abstract/13/3/492
UR - email: eru0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aspirin and colorectal cancer?
AU - Morgan, G.
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2004///
VL - 14
IS - 1
SP - 105
EP - 106
CY - Oxford; UK
PB - Oxford University Press
SN - 1101-1262
AD - Morgan, G.: National Public Health Service for Wales, 36 Orchard Street, Swansea SA1 5AQ, UK.
N1 - Accession Number: 20043057203. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 50-78-2. Subject Subsets: Public Health
KW - antineoplastic properties
KW - aspirin
KW - colon
KW - colorectal cancer
KW - human diseases
KW - neoplasms
KW - rectum
KW - risk reduction
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - acetylsalicylic acid
KW - anti-neoplastic properties
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043057203&site=ehost-live&scope=site
UR - email: gareth.morgan@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational exposures, anatomic location, and geographic distribution of laryngeal cancer.
AU - Elci, O. C.
AU - Akpinar-Elci, M.
JO - Cancer Causes & Control
JF - Cancer Causes & Control
Y1 - 2004///
VL - 15
IS - 4
SP - 429
EP - 430
CY - Dordrecht; Netherlands
PB - Kluwer Academic Publishers
SN - 0957-5243
AD - Elci, O. C.: Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, CDC/NIOSH/HELD, 1095 Willowdale Rd. MS3030, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043127690. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - anatomy
KW - exposure
KW - geographical distribution
KW - human diseases
KW - laryngeal cancer
KW - larynx
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043127690&site=ehost-live&scope=site
UR - http://ipsapp007.kluweronline.com/IPS/content/ext/x/J/4563/I/71/A/9/abstract.htm
UR - email: OElci@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk of medicines: counterfeit drugs.
AU - Akunyili, D. N.
AU - Nnani, I. P. C.
JO - International Journal of Risk & Safety in Medicine
JF - International Journal of Risk & Safety in Medicine
Y1 - 2004///
VL - 16
IS - 3
SP - 181
EP - 190
CY - Amsterdam; Netherlands
PB - IOS Press
SN - 0924-6479
AD - Akunyili, D. N.: National Agency for Food and Drug Administration and Control (NAFDAC), Nigeria.
N1 - Accession Number: 20043186387. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Protozoology
N2 - Living in general is a risky endeavour. Certain risks are taken without much thought because of the apparent overwhelming benefits. This is often the case for many consumers of medicines who assume medicines to be wholly safe and health care providers infallible. Patients rely on healthcare providers for information, risk assessment, and protection from risks due to medical interventions. Some common risks due to medical interventions include medication errors, exposure to radiation, over/under dosing, adverse events/reactions, hospital acquired infections, counterfeit drugs, etc. Unfortunately, risk factors such as counterfeit medicines (though occurring for a long time) are just becoming apparent in the last three decades, first to only a few countries while others still seem unaware or choose to dwell in denial of their existence. There has been an astronomical increase in the detection of counterfeit medicines worldwide. The magnitude of this increase and consequent death toll demands greater attention in the consideration of the safety of medicines. Counterfeit medicines constitute a risk to the pharmaceutical industry, healthcare providers, the healthcare system as a whole and ultimately to the patient. The risks to the patient include, lack of effect, toxicity, adverse drug reactions (ADRs), loss of economic and other resources and ultimately death. Due to dearth of information and research and lack of a globally coordinated approach to anti-counterfeiting, global estimates of deaths due to counterfeit medicines can only be guessed. Indications from both published data and anecdotal evidence indicate that millions of lives may be saved annually if there are no counterfeit antibiotics, antiretrovirals, anti-malarial, anti-tubercular drugs, vaccines and other life saving medicines. This paper identifies these risks and proposes a concerted global action towards reducing the production and circulation of counterfeit pharmaceuticals on the world market. It also suggests a possible role for pharmacovigilance in anti-counterfeiting.
KW - adverse effects
KW - antibiotics
KW - antimalarials
KW - antituberculous agents
KW - antiviral agents
KW - drugs
KW - health care
KW - mortality
KW - risk
KW - safety
KW - toxicity
KW - vaccines
KW - adverse reactions
KW - death rate
KW - medicines
KW - pharmaceuticals
KW - Pesticides and Drugs (General) (HH400)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Health Services (UU350)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043186387&site=ehost-live&scope=site
UR - http://iospress.metapress.com/app/home/contribution.asp?wasp=07wck7cqrm7unl48dr2p&referrer=parent&backto=issue,5,9;journal,1,17;linkingpublicationresults,1:103162,1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health and support service utilization patterns of American Indians and Alaska Natives diagnosed with HIV/AIDS.
AU - Ashman, J. J.
AU - Pérez-Jiménez, D.
AU - Marconi, K.
JO - AIDS Education and Prevention
JF - AIDS Education and Prevention
Y1 - 2004///
VL - 16
IS - 3
SP - 238
EP - 249
CY - New York; USA
PB - Guilford Publications
SN - 0899-9546
AD - Ashman, J. J.: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 7-90, Rockville, MD 20857, USA.
N1 - Accession Number: 20043118306. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - The purpose of this analysis is twofold: to examine the types of health and support services provided by CARE Act funded providers to American Indians/Alaska Natives (USA) and to compare the characteristics and service utilization patterns for this group with those of individuals from other racial/ethnic groups. We present an analysis of the demographic characteristics, service utilization, and health outcomes of all HIV-infected clients who received services in five geographic areas at agencies that were funded through the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act. Standard chi-square tests were used to test for statistically significant differences (p<0.05) between the demographic characteristics and service utilization patterns of matched pairs of HIV-positive American Indian/Native Alaskans with HIV-positive individuals of other racial and ethnic backgrounds. Individuals were matched on gender, age, insurance, AIDS diagnosis, and site. Other data examined include client characteristics (income, homelessness, HIV exposure category, and source of health care), health indicators (CDC-defined disease stage, CD4+ counts, substance abuse and psychiatric illness) and service utilization (medical care; mental health treatment/counselling; substance abuse treatment/counselling; case management; dental care; housing, food, emergency financial, and transportation assistance, and buddy/companion and client advocacy services). There were no statistically significant differences between the two groups for HIV exposure category, CD4 count, substance abuse problem, and being homeless and in their likelihood to receive medical care, mental health or substance abuse treatment/counselling, dental care, food, emergency financial, and transportation assistance, as well as buddy/companion and client advocacy services. They were more likely (55% vs. 46%) to receive case management services than the matched individuals from other racial/ethnic groups. They were also more likely to receive housing assistance (35% vs. 25%). The analysis provides evidence that when individuals are matched on key demographic and health characteristics, few differences remain between HIV-positive American Indians/Native Alaskans and other racial/ethnic groups. The two exceptions are case management and housing assistance. The significantly higher use of case management is not surprising, given the emphasis by American Indians/Alaska Natives on traditional Native American case management case management. In contrast, the significantly higher use of housing assistance by American Indians/Alaska Natives was unexpected. Exploring the potential need for housing assistance among all American Indians/Alaska Natives served by the Ryan White CARE Act needs to be considered.
KW - acquired immune deficiency syndrome
KW - Alaska Natives
KW - American indians
KW - CD4+ lymphocytes
KW - ethnic groups
KW - health services
KW - HIV infections
KW - housing
KW - human diseases
KW - human immunodeficiency viruses
KW - mental health
KW - substance abuse
KW - Alaska
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - case management
KW - CD4+ cells
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - T4 lymphocytes
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043118306&site=ehost-live&scope=site
UR - email: JAshman@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends and responsiveness in national resource allocation for needed HIV services: a five year (1996-2000) analysis.
AU - Young, S. R.
AU - Conviser, R.
AU - Marconi, K.
AU - Wieland, M. K.
JO - Journal of Health & Social Policy
JF - Journal of Health & Social Policy
Y1 - 2004///
VL - 17
IS - 4
SP - 1
EP - 14
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 0897-7186
AD - Young, S. R.: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Parklawn Building-Room 7-90, Rockville, MD 20857, USA.
N1 - Accession Number: 20043050486. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - A recent study conducted by the Institute of Medicine concluded that there are approximately 1200 to 1400 avoidable deaths per year in the USA among people living with HIV (PLWH) who do not have health insurance (Institute of Medicine, 2002). The Ryan White Comprehensive AIDS Resources Emergency (CARE) Act was passed by the US Congress in 1990 to provide funding for community-based HIV care services for uninsured and underinsured PLWH - the only Federal programme to provide such funding. There is substantial local autonomy in the allocation of CARE Act funds, with planning processes that take place in both States and metropolitan areas. The purpose of this study is to examine trends in the allocation of such funds from 1996 through 2000, the first five years during which effective antiretroviral medications were available for HIV. The study also considers whether these trends were responsive to the evolving modalities of care and the service needs of a changing population of PLWH.
KW - health insurance
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - resource allocation
KW - trends
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043050486&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques.
AU - Verthelyi, D.
AU - Wang, V. W.
AU - Lifson, J. D.
AU - Klinman, D. M.
JO - AIDS
JF - AIDS
Y1 - 2004///
VL - 18
IS - 7
SP - 1003
EP - 1008
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Verthelyi, D.: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A Rm 3B19, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043074537. Publication Type: Journal Article. Language: English. Number of References: 33 ref.
N2 - Objective: The development of an immunogenic vaccine against hepatitis B virus (HBV) is particularly important for HIV-infected patients since shared epidemiological risks result in HIV-infected subjects having a high incidence of HBV, and coinfection with HBV increases the occurrence of hepatotoxicity with antiretroviral therapy. Although HBV vaccination is recommended to all HIV-positive patients, its efficacy in these patients is reduced. Methods: Healthy (n=15) and SIV-infected (n=17) rhesus macaques were immunized with Engerix B alone or combined with type D or type K CpG ODN. SIV plasma RNA levels were determined by a real time reverse transcriptase polymerase chain reaction and antibody titers to HBV surface antigen (HbsAg) were measured by enzyme-linked immunosorbent assay every 2 weeks. Results: In healthy macaques, adding D or K ODN to Engerix B accelerated and boosted the titre of the anti-HbsAg response. In SIV-infected macaques, Engerix B alone elicited no detectable antibody response but a significant response was seen when it was combined with K or D ODN. The antibody titre induced by vaccinating HIV-infected macaques was inversely correlated with their initial viral load, with animals having >107 copies/ml being unable to mount a significant response. No adverse events or changes in SIV viral load were evident during the study. Conclusions: These findings support the development of clinical studies to assess the use of CpG ODN as an adjuvant for HBV vaccination in healthy and immunocompromised HIV-infected subjects.
KW - concurrent infections
KW - disease models
KW - hepatitis B
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunization
KW - vaccination
KW - vaccine development
KW - hepatitis B virus
KW - Macaca mulatta
KW - man
KW - simian immunodeficiency virus
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - oligodeoxynucleotide
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043074537&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gene and bacterial identification using high-throughput technologies: genomics, proteomics, and phonemics.
AU - Al-Khaldi, S. F.
AU - Mossoba, M. M.
T3 - Nutrigenomics Special Issue
JO - Nutrition
JF - Nutrition
Y1 - 2004///
VL - 20
IS - 1
SP - 32
EP - 38
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0899-9007
AD - Al-Khaldi, S. F.: 3E-014 DNA Microarray Lab, HFS-517, Division of Microbiological Studies, OPDFB, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA.
N1 - Accession Number: 20043044671. Publication Type: Journal Article. Note: Nutrigenomics Special Issue Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition; Public Health
N2 - The development of technologies in genomics, proteomics and phenomics for the identification of virulence genes and bacteria is discussed; these technologies include DNA microarray, protein microarray and phenotype microarray. The applications of these technologies and their limitations are also discussed.
KW - genes
KW - genomes
KW - genomics
KW - human diseases
KW - methodology
KW - molecular genetics
KW - proteomics
KW - bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - methods
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043044671&site=ehost-live&scope=site
UR - email: sufian.al-khaldi@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular markers for early detection of cervical neoplasia.
AU - Unger, E. R.
AU - Steinau, M.
AU - Rajeevan, M. S.
AU - Swan, D.
AU - Lee, D. R.
AU - Vernon, S. D.
JO - Disease Markers
JF - Disease Markers
Y1 - 2004///
VL - 20
IS - 2
SP - 103
EP - 116
CY - Amsterdam; Netherlands
PB - IOS Press
SN - 0278-0240
AD - Unger, E. R.: Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road, MS G41, Atlanta, GA 30333, USA.
N1 - Accession Number: 20043150302. Publication Type: Journal Article. Language: English. Number of References: 99 ref. Subject Subsets: Public Health
N2 - A review is presented to provide an overview of the large number of studies that have correlated a variety of markers with cervical cancer and pre-invasive cervical neoplasia, and to highlight areas and approaches that appear most promising for early detection. While ideal early detection markers would be applicable to non-invasively collected samples, markers applied to histological samples are included because those most promising could potentially be adapted to an alternative sampling approach. Many markers have been investigated since the 1980s, but specific citations emphasize publications within the past 5 years.
KW - cervical cancer
KW - cervix
KW - diagnostic value
KW - early diagnosis
KW - genetic markers
KW - histology
KW - human diseases
KW - marker genes
KW - neoplasms
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043150302&site=ehost-live&scope=site
UR - email: eunger@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Susceptibility of Anopheles farauti to infection with different species of Plasmodium.
AU - Nace, D.
AU - Williams, T.
AU - Sullivan, J.
AU - Williams, A.
AU - Galland, G. G.
AU - Collins, W. E.
JO - Journal of the American Mosquito Control Association
JF - Journal of the American Mosquito Control Association
Y1 - 2004///
VL - 20
IS - 3
SP - 272
EP - 276
CY - Eatontown; USA
PB - American Mosquito Control Association, Inc.
SN - 8756-971X
AD - Nace, D.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 20043187797. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Tropical Diseases; Protozoology; Medical & Veterinary Entomology
N2 - A colony of Anopheles farauti, originally from the island of New Britain in Papua New Guinea, was tested for its receptivity to infection with different species of Plasmodium in comparison with A. freeborni and A. stephensi. This colony adapted well to feeding on monkeys and was infected with New World and Old World strains of P. vivax and P. falciparum, P. ovale, P. cynomolgi, and P. brasilianum.
KW - disease vectors
KW - malaria
KW - susceptibility
KW - Papua New Guinea
KW - Anopheles farauti
KW - Anopheles freeborni
KW - Anopheles stephensi
KW - Culicidae
KW - Plasmodium brasilianum
KW - Plasmodium cynomolgi
KW - Plasmodium falciparum
KW - Plasmodium ovale
KW - Plasmodium vivax
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - ACP Countries
KW - APEC countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - New Guinea
KW - Melanesia
KW - Australasia
KW - Oceania
KW - Pacific Islands
KW - mosquitoes
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043187797&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multipathogen oligonucleotide microarray for environmental and biodefense applications.
AU - Sergeev, N.
AU - Distler, M.
AU - Courtney, S.
AU - Al-Khaldi, S. F.
AU - Volokhov, D.
AU - Chizhikov, V.
AU - Rasooly, A.
T3 - Special Issue: Microarrays for Biodefense and Environmental Applications
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2004///
VL - 20
IS - 4
SP - 684
EP - 698
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0956-5663
AD - Sergeev, N.: FDA Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20043200620. Publication Type: Journal Article. Note: Special Issue: Microarrays for Biodefense and Environmental Applications Language: English. Subject Subsets: Human Nutrition
N2 - Food-borne pathogens are a major health problem. The large and diverse number of microbial pathogens and their virulence factors has fueled interest in technologies capable of detecting multiple pathogens and multiple virulence factors simultaneously. Some of these pathogens and their toxins have potential use as bioweapons. DNA microarray technology allows the simultaneous analysis of thousands of sequences of DNA in a relatively short time, making it appropriate for biodefense and for public health uses. This paper describes methods for using DNA microarrays to detect and analyze microbial pathogens. The FDA-1 microarray was developed for the simultaneous detection of several food-borne pathogens and their virulence factors including Listeria spp., Campylobacter spp., Staphylococcus aureus enterotoxin genes and Clostridium perfringens toxin genes. Three elements were incorporated to increase confidence in the microarray detection system: redundancy of genes, redundancy of oligonucleotide probes (oligoprobes) for a specific gene, and quality control oligoprobes to monitor array spotting and target DNA hybridization. These elements enhance the reliability of detection and reduce the chance of erroneous results due to the genetic variability of microbes or technical problems with the microarray. The results presented demonstrate the potential of oligonucleotide microarrays for detection of environmental and biodefense relevant microbial pathogens.
KW - detection
KW - DNA hybridization
KW - enterotoxins
KW - environment
KW - genes
KW - oligonucleotides
KW - pathogens
KW - public health
KW - quality controls
KW - virulence
KW - Campylobacter
KW - Clostridium perfringens
KW - Listeria
KW - Staphylococcus aureus
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Staphylococcus
KW - Staphylococcaceae
KW - arrays
KW - bacterium
KW - biodefence
KW - microarrays
KW - oligoprobes
KW - quality assurance
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043200620&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TFC-4D4PSD8-6&_user=10&_handle=B-WA-A-W-BU-MsSAYVA-UUW-AAUVYWWWBE-AAUWVUBUBE-DEUEWDZEU-BU-U&_fmt=summary&_coverDate=11%2F01%2F2004&_rdoc=3&_orig=browse&_srch=%23toc%235223%232004%23999799995%23526154!&_cdi=5223&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b613f7027a14a8179c0725512e3a70fc
UR - email: rasoslya@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Technology for supercritical CO2 fluid extraction of tocotrienols from hulless-barley.
AU - Xia XiangDong
AU - LüFeiJie
AU - Tai JianXiang
AU - Fu Qin
JO - Transactions of the Chinese Society of Agricultural Engineering
JF - Transactions of the Chinese Society of Agricultural Engineering
Y1 - 2004///
VL - 20
IS - 5
SP - 191
EP - 195
CY - Beijing; China
PB - Chinese Society of Agricultural Engineering
SN - 1002-6819
AD - Xia XiangDong: State Food and Drug Administration, Beijing 100810, China.
N1 - Accession Number: 20043200198. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 15 ref. Registry Number: 64-17-5. Subject Subsets: Human Nutrition; Wheat, Barley & Triticale Abstracts
N2 - The supercritical CO2 extraction of tocotrienols from hulless-barley was researched. The effects of temperature, pressure, ethanol concentration and extraction time on the extracting rate of tocotrienols were discussed with quadratic perpendicularity and universal rotation regression mathematical model. Extraction temperature had a significant effect (α=0.05) on the extracting rate of tocotrienols, while the ethanol concentration and extraction time have a very significant effect (α=0.01) on the extracting rate of tocotrienols. The interaction between pressure and ethanol concentration had a significant effect on the extraction rate of tocotrienols, but not the extraction pressure alone. The optimum SFE-CO2 parameters for extracting tocotrienols were the extraction temperature 51.8°C, the pressure 34.7 MPa, the ethanol concentration 9% and the extraction time 120 min.
KW - barley
KW - chemical composition
KW - ethanol
KW - extraction
KW - mathematical models
KW - supercritical fluid extraction
KW - tocotrienols
KW - Hordeum vulgare
KW - Hordeum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - ethyl alcohol
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043200198&site=ehost-live&scope=site
UR - email: XXD626@126.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA microarray analysis of protozoan parasite gene expression: outcomes correlate with mechanisms of regulation.
AU - Duncan, R.
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2004///
VL - 20
IS - 5
SP - 211
EP - 215
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 1471-4922
AD - Duncan, R.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 1401 Rockville Pk, Rockville, MD 20852, USA.
N1 - Accession Number: 20043077900. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Protozoology
N2 - DNA microarray analysis has been successfully applied to most of the protozoan parasites that cause human disease, but has not made equal progress in all cases. The results for kinetoplastid parasites (Leishmania and Trypanosoma) are primarily at the stage of validation and new gene discovery. By contrast, the results for apicomplexan parasites (Plasmodium and Toxoplasma) have advanced to the analysis of coordinate regulation of clusters of genes. This difference in progress relates to the more complete genome sequence identified for the apicomplexans and, more significantly, to the differences in the regulation of gene expression between these two groups.
KW - gene expression
KW - genes
KW - genomes
KW - nucleotide sequences
KW - Leishmania
KW - Plasmodium
KW - Toxoplasma
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Sarcocystidae
KW - Eucoccidiorida
KW - DNA sequences
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043077900&site=ehost-live&scope=site
UR - email: duncan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV type 2 primary isolates induce a lower degree of apoptosis "in vitro" compared with HIV type 1 primary isolates.
AU - Machuca, A.
AU - Ding, L.
AU - Taffs, R.
AU - Lee, S.
AU - Wood, O.
AU - Hu, J. J.
AU - Hewlett, I.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 2004///
VL - 20
IS - 5
SP - 507
EP - 512
CY - Larchmont; USA
PB - Mary Ann Liebert, Inc.
SN - 0889-2229
AD - Machuca, A.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043135483. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - To determine whether subtypes of HIV-1 and HIV-2 vary in their ability to induce T cell apoptosis in vitro, human peripheral blood mononuclear cells (PBMC) from healthy donors and CEM.NKR-CCR5 cells were infected with a variety of HIV-1 and HIV-2 isolates in vitro. Apoptotic cell levels and chemokine and cytokine production were analysed. Significant variations in cytopathic effects following in vitro infection with primary isolates of HIV-1 or HIV-2 subtypes were observed in PBMCs. The percent of apoptotic cells from each individual ranged from 2 to 78% after HIV-1 infection and from 0 to 28% after HIV-2 infection (P<0.01). We did not observe significant differences in the degree of apoptosis induced among cells infected with different HIV-1 group M subtypes or group O virus, nor among cells infected with different HIV-2 isolates. However, HIV-2 induced significantly lower degree of apoptosis overall in PBMC and CEM.NKR-CC5 cells when compared with HIV-1 subtypes (P<0.0001). No significant differences were observed in the production of chemokines, such as RANTES, MIP-1α, and MIP-1β, and cytokines, such as TNF-α and TNF-β when PBMC cultures were infected with different HIV-1 subtype viruses, or HIV-2 isolates. In conclusion, HIV-2 isolates induced significantly lower levels of T cell apoptosis in both PBMC and CEM.NKR-CCR5 cells than HIV-1 isolates. No differences in T cell apoptosis levels were seen between different subtypes of HIV-1 group M or group O isolates. This is consistent with the mild clinical course of infection with HIV-2 that has been reported relative to that observed with HIV-1.
KW - apoptosis
KW - HIV-1 infections
KW - HIV-2 infections
KW - human diseases
KW - in vitro
KW - pathogenesis
KW - T lymphocytes
KW - Human immunodeficiency virus 1
KW - Human immunodeficiency virus 2
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus type 1
KW - human immunodeficiency virus type 2
KW - T cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.
AU - Owen, S. M.
AU - Rudolph, D. L.
AU - Wang, W.
AU - Cole, A. M.
AU - Waring, A. J.
AU - Lal, R. B.
AU - Lehrer, R. I.
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
Y1 - 2004///
VL - 20
IS - 11
SP - 1157
EP - 1165
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 0889-2229
AD - Owen, S. M.: HIV Immunology and Diagnostic Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 1600 Clifton Road, MS A25, Atlanta, GA 30333, USA.
N1 - Accession Number: 20083064629. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Subject Subsets: Public Health
N2 - Rhesus macaques express three θ-defensins (RTDs 1-3), cyclic octadecapeptides with antiviral and lectin-like properties. Corresponding θ-defensin genes exist and are expressed in humans, but a signal sequence mutation prevents the formation of mature θ-defensin peptides. Retrocyclin-1 is a θ-defensin peptide whose precursor is encoded by human θ-defensin pseudogenes. It can protect human peripheral blood lymphocytes from infection by R5 and X4 strains of HIV-1, and provides a molecular template for designing novel antiviral agents. In this study, we used JC53-BL reporter cells to assess the activity of retrocyclin-1 (RC-100) and several analogues against primary HIV-1 isolates, including R5 and R5X4 strains of subtypes A-D, CRF-01_AE, and recombinants. Each analogue differed from retrocyclin-1 by a single amino acid substitution: Gly -> Tyr in RC-106, RC-115, and RC-116, and Arg -> Lys in RC-101. Although the modification in RC-101 was chemically conservative, this peptide was significantly more potent than retrocyclin-1 across the panel of primary isolates. We performed surface plasmon resonance binding studies, using recombinant gp120 and CD4 produced in insect cells. Although RC-100 and RC-101 bound gp120 LAV/IIIB with a Kd of 30-35 nM, they bound gp120 from CRF-01_AE strains (CM 235 and 93TH975.15) with Kd values of 200-750 nM. Overall, our findings suggest that clade-related differences in gp120 glycosylation impact the ability of retrocyclin-1 to bind this viral glycoprotein, and modulate the peptides' ability to prevent HIV-1 infection. The performance of RC-101 suggests that additional "engineering" could further enhance the antiviral properties of θ-defensins.
KW - CD4+ lymphocytes
KW - envelope protein gp120
KW - glycoproteins
KW - HIV-1 infections
KW - human diseases
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CD4+ cells
KW - gp120
KW - Human immunodeficiency virus type 1
KW - RC-101
KW - retrocyclin-1
KW - T4 lymphocytes
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083064629&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/pdfplus/10.1089/aid.2004.20.1157
UR - email: smo2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of acidulant identity on the effects of pH and acid resistance on the radiation resistance of Escherichia coli O157:H7.
AU - Buchanan, R. L.
AU - Edelson-Mammel, S. G.
AU - Boyd, G.
AU - Marmer, B. S.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004///
VL - 21
IS - 1
SP - 51
EP - 57
CY - London; UK
PB - Academic Press
SN - 0740-0020
AD - Buchanan, R. L.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20043013759. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 64-19-7, 77-92-9, 7647-01-0, 50-21-5, 6915-15-7. Subject Subsets: Soyabeans
N2 - The effects of pH (4.0-5.5), acid identity (acetic, citric, lactic, malic, and hydrochloric), and the induction of pH-dependent stationary phase acid resistance on the radiation resistance of E. coli O157:H7 Ent-C9490 was studied using cells grown in Tryptic Soy Broth with and without dextrose (induced and non-induced to acid resistance) and then resuspended in brain-heart infusion broth containing 5 g/litre of an organic acid and acidified with concentrated hydrochloric acid. After treatment with gamma radiation, the number of survivors was determined by plating on brain-heart infusion agar (injured and non-injured cells) and MacConkey agar (non-injured cells), and the data used to calculate radiation D-values. The induction of pH-dependent stationary phase acid resistance consistently provided the enterohemorrhagic E. coli strain cross-protection from subsequent irradiation, increasing radiation D-values by 1.2- to 3.3-fold, depending on the organic acid present. The radiation resistance of E. coli varied with acid identity, but was largely unaffected by pH within the range examined. The results indicate that induction of cross-protection resulting from induction of acid resistance is a factor that should be considered to accurately determine the radiation dose needed to inactivate enterohemorrhagic E. coli in foods.
KW - acetic acid
KW - acidulants
KW - citric acid
KW - food additives
KW - food contamination
KW - food microbiology
KW - hydrochloric acid
KW - irradiation
KW - lactic acid
KW - malic acid
KW - microbial contamination
KW - pH
KW - Escherichia coli
KW - Escherichia coli O157
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia coli
KW - bacterium
KW - E. coli
KW - food contaminants
KW - hydrogen ion concentration
KW - lactate
KW - malate
KW - potential of hydrogen
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043013759&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The inactivation of Listeria monocytogenes by pulsed electric field (PEF) treatment in a static chamber.
AU - Fleischman, G. J.
AU - Ravishankar, S.
AU - Balasubramaniam, V. M.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004///
VL - 21
IS - 1
SP - 91
EP - 95
CY - London; UK
PB - Academic Press
SN - 0740-0020
AD - Fleischman, G. J.: US Food and Drug Administration, The National Center for Food Safety & Technology, 6502, South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20043013765. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Dairy Science
N2 - An experimental analysis of the effect of pulsed electric field (PEF) energy on the inactivation of Listeria monocytogenes was conducted using a custom-designed static chamber and a gel suspension medium for treatment. This allowed PEF energy to be delivered to the suspension under near isothermal conditions. The effects of variations in the number of pulses (5-50 pulses), electric field strength (15-30 kV/cm), temperature (0-60°C) and media bases (water and skim milk) on the inactivation of L. monocytogenes were examined. At temperatures less than 50°C a maximum of 1 log reduction was obtained for L. monocytogenes regardless of pulse number or electric field strength within the ranges examined. In skim milk no reduction occurred. At 50°C and 55°C synergy between PEF and thermal energy was observed. The experimental approach separated the contribution of PEF and thermal energy to total kill and thus allowed this synergy to be quantified. At 55°C the kill due to PEF energy increased to 4.5 logs with another 4.5 logs reduction attributable to thermal energy. It appears that under the conditions of this study PEF alone has a very limited effect on the reduction of L. monocytogenes. However, the addition of thermal energy not only contributed to the kill, but also increased the susceptibility of L. monocytogenes to PEF energy.
KW - decontamination
KW - electric field
KW - food contamination
KW - food microbiology
KW - food processing
KW - microbial contamination
KW - milk
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Milk and Dairy Produce (QQ010)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043013765&site=ehost-live&scope=site
UR - email: gfleisch@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunomodulating fungal and plant polysaccharides; biochemistry, immunologic activity and clinical application.
AU - Lee, C. J.
AU - Huo, Y. S.
AU - Lee, L. H.
AU - Lu ChengHsiung
AU - Koizumi, K.
JO - Journal of Traditional Medicines
JF - Journal of Traditional Medicines
Y1 - 2004///
VL - 21
IS - 2
SP - 67
EP - 80
CY - Sugitani; Japan
PB - Medical and Pharmaceutical Society for Wakan-Yaku
SN - 1340-6302
AD - Lee, C. J.: Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA.
N1 - Accession Number: 20043121306. Publication Type: Journal Article. Language: English. Language of Summary: Japanese. Number of References: 112 ref. Subject Subsets: Medical & Veterinary Entomology; Crop Physiology; Aromatic & Medicinal Plants; Horticultural Science
N2 - The polysaccharide (PS) fractions isolated from fungi and higher plants have been shown as potent biological response modifiers exhibiting immunostimulating and antitumour activities through the functions involving activation of macrophages, cell-mediated immunity and cytokine induction. The primary structure of these PSs exhibits β (1->3), β (1->4)-linkage glycan as the common form of main chain, while the side chains involve β (1->3), β (1->4), β (1->6) or α (1->4) linkages. The hydrogen bond, tertiary structure of triple helix, and high molecular weight contribute to the stability and biological activities of the PSs. The degree of substitution on the backbone chain and the length of the side chains are important for the conformation of structure and their immunologic activity. Here, we review the biochemical characterization, immunomodulating activities, and clinical application of important PSs isolated from fungi including Lentinus edodes [Lentinula edodes], Coriolus versicolor, Ganoderma lucidum, G. japonicum, Hoelen (Poria cocos [Wolfiporia extensa]), Polyporus umbellatus, Cordyceps ophioglossoides and Cordyceps cicadae, and higher plants such as Radix Astragali (Astragalus membranaceus var. mongholicus), Angelica (Angelica sinensis), Ginseng (Panax ginseng), and others including Cnidium rhizoma [Cnidium sp.], Lycium barbarum, Codonopsis pilosula var. modesta, Codonopsis tangshen, Acanthopanax chiisanensis and Acanthopanax senticosus [Eleutherococcus senticosus]. Immunomodulating PSs thus far have been used to prevent disease and promote restoration of the body's homeostasis, and current evaluations focus on treatment of pathogenic factors. Development of these polysaccharides into drugs for therapeutic use needs research on structure-activity relationship and quality assurance for polysaccharide molecules and final products.
KW - antineoplastic properties
KW - chemical structure
KW - immunity
KW - immunostimulatory properties
KW - macrophage activation
KW - medicinal fungi
KW - medicinal plants
KW - polysaccharides
KW - reviews
KW - structure activity relationships
KW - Acanthopanax
KW - Agaricomycotina
KW - Angelica gigas
KW - Angelica sinensis
KW - Astragalus
KW - Clavicipitaceae
KW - Cnidium
KW - Codonopsis
KW - Cordyceps
KW - Eleutherococcus senticosus
KW - Ganoderma lucidum
KW - Ganodermataceae
KW - Lentinula edodes
KW - Lycium
KW - Panax ginseng
KW - Polyporaceae
KW - Polyporus
KW - Trametes versicolor
KW - Tricholomataceae
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Angelica
KW - Apiaceae
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Basidiomycota
KW - fungi
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - Campanulaceae
KW - Campanulales
KW - Cordycipitaceae
KW - Coriolus
KW - Polyporaceae
KW - Polyporales
KW - Agaricomycetes
KW - Agaricomycotina
KW - Eleutherococcus
KW - Ganoderma
KW - Ganodermataceae
KW - Lentinula
KW - Marasmiaceae
KW - Agaricales
KW - Solanaceae
KW - Solanales
KW - Panax
KW - Acanthopanax
KW - Astragalus
KW - Codonopsis
KW - Cordyceps
KW - Lycium
KW - Paecilomyces
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Polyporus
KW - Trametes
KW - Acanthopanax chiisanensis
KW - Angelica polymorpha
KW - Angelica polymorpha subsp. sinensis
KW - anti-neoplastic properties
KW - Araliales
KW - Astragalus membranaceus
KW - Basidiomycetes
KW - Basidiomycotina
KW - Codonopsis pilosula
KW - Codonopsis tangshen
KW - complex carbohydrates
KW - Cordyceps cicadae
KW - Cordyceps ophioglossoides
KW - Coriolaceae
KW - Coriolus versicolor
KW - drug plants
KW - Eleutherococcus divaricatus
KW - Eleutherococcus divaricatus var. chiisanensis
KW - fungus
KW - Ganoderma japonicum
KW - Ganodermatales
KW - Hyphomycetes
KW - immunopotentiating properties
KW - immunostimulant properties
KW - Isaria cicadae
KW - Lycium barbarum
KW - medicinal herbs
KW - officinal plants
KW - Paecilomyces cicadae
KW - Polyporus umbellatus
KW - Poriales
KW - Wolfiporia
KW - Wolfiporia extensa
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Physiology and Biochemistry (FF060)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
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UR - email: lee_chi@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of lead and cadmium in wines by graphite furnace atomic absorption spectrometry.
AU - Kim MeeHye
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2004///
VL - 21
IS - 2
SP - 154
EP - 157
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Kim MeeHye: Department of Food Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20043032782. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Human Nutrition; Tropical Diseases
N2 - Lead (Pb) and cadmium (Cd) contents of various wines on the Korean market were determined by graphite furnace atomic absorption spectrometry using Zeeman background correction and peak area mode. All wine samples were microwave-digested in concentrated HNO3. Ammonium dihydrogen phosphate and magnesium nitrate were used as matrix modifiers for both Pb and Cd analyses. The mean Pb content of the wines was approximately 29 µg/litre, ranging from 5-87 µg/litre. Also, the means of Cd were ~0.5 µg/litre, ranging from <0.1-3.0 µg/litre. The mean recoveries of Pb and Cd were 92.8 and 101.3% and their analytical detection limits were 1.0 and 0.1 µg/litre, respectively. Sixty brands of wine were classified into red and white, but no statistically significant difference in Pb and Cd content was observed.
KW - analytical methods
KW - cadmium
KW - food contamination
KW - food safety
KW - lead
KW - spectrometry
KW - wines
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - analytical techniques
KW - food contaminants
KW - graphite furnace atomic absorption spectrometry
KW - South Korea
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043032782&site=ehost-live&scope=site
UR - email: meehkim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Riboprint analysis of Listeria monocytogenes isolates obtained by FDA from 1999 to 2003.
AU - Gendel, S. M.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004///
VL - 21
IS - 2
SP - 187
EP - 191
CY - London; UK
PB - Academic Press
SN - 0740-0020
AD - Gendel, S. M.: Biotechnology Studies Branch, Food and Drug Administration, National Center for Food Safety and Technology, 6502 S Archer Rd, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20043044309. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Listeria monocytogenes is a widespread human and animal pathogen. Despite the potential value of ribotyping for tracking patterns of strain distribution in Listeria monocytogenes, the application of this technology for this species has been limited to sets of isolates that are linked either by epidemiology, geography, or food type. To broadly characterize the population structure of L. monocytogenes, automated ribotyping was carried out on a large set of unrelated isolates obtained by the US FDA from late 1999 to early 2003. The results showed the widespread occurrence of a few strains, and no indication of geographic or food-related stratification.
KW - population structure
KW - ribotyping
KW - strains
KW - USA
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043044309&site=ehost-live&scope=site
UR - email: sgendel@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mercury, cadmium and arsenic contents of calcium dietary supplements.
AU - Kim MeeHye
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2004///
VL - 21
IS - 8
SP - 763
EP - 767
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Kim MeeHye: Department of Food Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20043153822. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 7440-38-2, 7440-43-9, 7440-70-2, 7439-97-6. Subject Subsets: Human Nutrition
N2 - The cadmium (Cd) and arsenic (As) contents of calcium (Ca) supplements available on the Korean market were determined by a graphite furnace atomic absorption spectrometer using Zeeman background correction and peak area mode after microwave digestion. The mercury (Hg) content of the supplements was measured using an Hg analyser. Recoveries ranged from 92 to 98% for Hg, Cd and As analyses. Fifty-five brands of Ca supplements were classified into seven categories based on the major composite: bone, milk, oyster/clam shell, egg shell, algae, shark cartilage and chelated. The means of Hg, Cd and As in Ca supplements were 0.01, 0.02, and 0.48 mg kg-1, respectively. Ca supplements made of shark cartilage had the highest means of Hg (0.06 mg kg-1) and Cd (0.13 mg kg-1). The mean daily intakes of Hg and Cd from the supplement were estimated as about 0.1-0.2 µg, with both contributing less than 0.4% of provisional tolerable daily intakes set by the Food and Agricultural Organization/World Health Organization Joint Food Additive and Contaminants Committee.
KW - arsenic
KW - cadmium
KW - calcium
KW - food contamination
KW - food supplements
KW - heavy metals
KW - mercury
KW - mineral supplements
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043153822&site=ehost-live&scope=site
UR - email: meehkim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - LC-UV and LC-MS analysis of food and drink products containing kava.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2004///
VL - 21
IS - 10
SP - 921
EP - 934
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Jager, L. S. de: US Food and Drug Administration, Centre for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland, USA.
N1 - Accession Number: 20043209462. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science; Aromatic & Medicinal Plants
N2 - A method for the determination of six kava lactones, methysticin, dihydromethysticin, kawain, dihydrokawain, yangonin and desmethoxyyangonin, in solid foods and beverages has been developed. Solid samples were prepared using methanol extraction, while beverages were extracted using a separate solid phase extraction (SPE) method. After sample preparation, the extracts were analysed using LC-UV or atmospheric pressure photoionization (APPI) LC-MS in the positive mode. Using the method, 10 beverage products, two chocolate products, three unbrewed tea products, three dietary supplements and a drink mix product were analysed. The results obtained using the LC-UV were comparable to those obtained using APPI-LC-MS for most products. Using the SPE method in conjunction with LC-MS, individual kava lactones were detected in drink products at ppb concentrations. Concentrations of total kava lactones ranged between 135-0.035 mg per serving in the food and beverage products tested and between 40-61 mg per serving for the dietary supplement products tested. Results of these analyses as well as extraction efficiency and reproducibility data are reported.
KW - analytical methods
KW - beverages
KW - chemical composition
KW - food additives
KW - food contamination
KW - food safety
KW - food supplements
KW - lactones
KW - liquid chromatography
KW - mass spectrometry
KW - milk products
KW - tea
KW - Camellia sinensis
KW - Piper methysticum
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Piper
KW - Piperaceae
KW - Piperales
KW - analytical techniques
KW - dairy products
KW - desmethoxyyangonin
KW - dihydrokawain
KW - dihydromethysticin
KW - drinks
KW - food contaminants
KW - kawain
KW - methysticin
KW - yangonin
KW - Crop Produce (QQ050)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043209462&site=ehost-live&scope=site
UR - email: ldejager@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Migration of a UV stabilizer from polyethylene terephthalate (PET) into food simulants.
AU - Begley, T. H.
AU - Biles, J. E.
AU - Cunningham, C.
AU - Piringer, O.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2004///
VL - 21
IS - 10
SP - 1007
EP - 1014
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Begley, T. H.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20043209460. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition; Agricultural Engineering
N2 - The migration characteristics of the UV stabilizer Tinuvin 234 (2-(2H-benzotriazol-2-yl)-4,6-bis (1-methyl-1-phenylethyl)phenol) into food simulants has been measured from polyethylene terephthalate (PET) using HPLC with UV detection. Ethanol/water, isooctane and a fractionated coconut oil simulant (Miglyol®) were used as food simulating solvents. The migration characteristics were measured at temperatures in the range of 40-70°C. Diffusion coefficients were determined to be in the range of 1×10-14 cm2 s-1 to 1×10-18 cm2 s-1. At 40°C, the amount of migration into 95% ethanol after 10 days was 2 µg dm-2. Isooctane is determined to be a good fatty food simulant that provides similar results for PET to those of fatty foods.
KW - food contamination
KW - packaging materials
KW - toxic substances
KW - food contaminants
KW - poisons
KW - polyethylene terepthalate
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043209460&site=ehost-live&scope=site
UR - email: timothy.begley@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Papers from ISGNAS meeting, Herborn, Germany. 23-25 June, 2003.
AU - Walker, R. I.
A2 - Walker, R. I.
T2 - Vaccine
T3 - Special Issue: Possibilities for active and passive vaccination against opportunistic infections
JO - Vaccine
JF - Vaccine
Y1 - 2004///
VL - 22
IS - 7
SP - 801
EP - 908
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Walker, R. I.: Center for Biologics Evaluation and Research, Division of Bacterial, Parasitic and Allergenic Products, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20043033786. Publication Type: Journal issue; Conference proceedings. Note: Special Issue: Possibilities for active and passive vaccination against opportunistic infections Language: English. Subject Subsets: Public Health
N2 - This special issue contains 13 papers focusing on the possibilities for vaccination against opportunistic infections. The major topics discussed are: definition of opportunistic pathogen; the use of passively administered antibodies against opportunistic pathogens; candidates for active vaccination; immune responses to opportunistic pathogens; application of emerging technologies to the immunological control of opportunistic infections; and the challenges of clinical trial design.
KW - antibodies
KW - candidate vaccines
KW - clinical trials
KW - human diseases
KW - immune response
KW - immunization
KW - immunocompromised hosts
KW - opportunistic infections
KW - passive immunization
KW - pathogens
KW - vaccination
KW - vaccine development
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - immunomodulation
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043033786&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preventive vaccines against bioterrorism: evaluation of efficacy and safety.
AU - Horne, A. D.
AU - Clifford, J.
AU - Goldenthal, K. L.
AU - Kleppinger, C.
AU - Lachenbruch, P. A.
JO - Vaccine
JF - Vaccine
Y1 - 2004///
VL - 23
IS - 1
SP - 84
EP - 90
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0264-410X
AD - Horne, A. D.: Division of Biostatistics, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research (CBER), FDA, HFM-217, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20043203136. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - This paper discusses the US Food and Drug Administration's approach to evaluation of vaccines in general, and vaccines against diseases of bioterrorism in particular. We summarize the scientific bases for development and approval of vaccines and then discuss specific issues regarding vaccines against disease organisms that could potentially be used as weapons of bioterrorism.
KW - antigens
KW - biological warfare
KW - bioterrorism
KW - disease prevention
KW - efficacy
KW - human diseases
KW - pathogens
KW - safety
KW - vaccine development
KW - vaccines
KW - war
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antigenicity
KW - immunogens
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043203136&site=ehost-live&scope=site
UR - email: horne@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical predictors of bloodstream infections and mortality in hospitalized Malawian children.
AU - Norton, E. B.
AU - Archibald, L. K.
AU - Nwanyanwu, O. C.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Reller, L. B.
AU - Jarvis, W. R.
AU - Jason, J.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2004///
VL - 23
IS - 2
SP - 145
EP - 151
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Norton, E. B.: HIV Immunology and Diagnostics Branch, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control, Department of Health and Human Services, US Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20043046113. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Protozoology; Rural Development; Tropical Diseases
N2 - Background: In sub-Saharan Africa, bloodstream infections (BSI) are a major cause of pediatric mortality. Because of limited resources and facilities in these developing countries, treatment often must be based solely on clinical observations and patient history and includes the use of broad spectrum antimicrobials, a factor in the emergence of antibiotic resistance. Methods: During July 28 through August 18, 1998 we analyzed clinical, epidemiologic and microbiologic data from a cohort of 225 hospitalized children in Malawi, Africa, to determine clinical indices associated with the presence/absence of BSI and/or mortality for use in settings with minimal microbiologic laboratory and intensive care facilities. Results: BSI (n=35 children) were associated with malnutrition, chronic cough, lethargy by history, lethargy on examination and oral thrush; 92% of children without these symptoms were BSI-negative. Mortality (21 of 173 children with known mortality status) was associated with malnutrition, lethargy on examination, prior receipt of antimalarials and acute decreased feeding. Of those with ≥2 of these indices 69% died; of those with <2 of the indices 94% survived. Infection with human immunodeficiency virus was not significantly related to either BSI or mortality status. Conclusions: Malnutrition, but not HIV, was strongly related to both BSI and mortality. Assessment of these BSI and mortality indices at hospital admission provides rapid, cost-free indication of which children are most/least in need of empiric antimicrobial therapy or intensive observation, thereby maximizing appropriate use of antimicrobials and limited facilities while minimizing inappropriate antimicrobial usage.
KW - aetiology
KW - antiinfective agents
KW - antimalarials
KW - bloodstream infections
KW - children
KW - cough
KW - drug therapy
KW - epidemiology
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - malnutrition
KW - mortality
KW - viral diseases
KW - Malawi
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - East Africa
KW - Africa South of Sahara
KW - Least Developed Countries
KW - Developing Countries
KW - SADC Countries
KW - antimicrobials
KW - causal agents
KW - chemotherapy
KW - death rate
KW - etiology
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Nyasaland
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043046113&site=ehost-live&scope=site
UR - email: enorton@tulane.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fusidic acid resistance in community isolates of methicillin susceptible Staphylococcus aureus and the use of topical fusidic acid: a retrospective case-control study.
AU - Mason, B. W.
AU - Howard, A. J.
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2004///
VL - 23
IS - 3
SP - 300
EP - 303
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0924-8579
AD - Mason, B. W.: National Public Health Service for Wales, Communicable Disease Surveillance Centre (Wales), Abton House, Wedal Road, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20043046617. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 6990-06-3, 751-94-0, 61-32-5. Subject Subsets: Public Health
N2 - Resistance to fusidic acid among community methicillin susceptible Staphylococcus aureus (MSSA) isolates in the United Kingdom and prescriptions for fusidic acid have both doubled over the past 6 years. A retrospective case-control study was undertaken to test the hypothesis that the use of topical fusidic acid is associated with the isolation of resistant organisms. A statistically significant association was found between fusidic acid resistance in MSSA isolates and exposure to topical fusidic acid (odds ratio: 2.77, 95% CI 1.01-7.93, P=0.027). This study demonstrates for the first time an association between the use of topical fusidic acid and resistance at the individual patient level and supports the hypothesis that the observed increase in resistance is causally associated with the increased use of topical fusidic acid.
KW - antibacterial agents
KW - bacterial diseases
KW - drug resistance
KW - drug susceptibility
KW - fusidic acid
KW - human diseases
KW - methicillin
KW - strains
KW - UK
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - United Kingdom
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043046617&site=ehost-live&scope=site
UR - email: brendan.mason@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Understanding vaccine safety information from the Vaccine Adverse Event Reporting System.
AU - Varricchio, F.
AU - Iskander, J.
AU - Destefano, F.
AU - Ball, R.
AU - Pless, R.
AU - Braun, M. M.
AU - Chen, R. T.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2004///
VL - 23
IS - 4
SP - 287
EP - 294
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Varricchio, F.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, USA.
N1 - Accession Number: 20043077008. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Public Health
N2 - The Vaccine Adverse Event Reporting System (VAERS) is administered by the Food and Drug Administration and CDC and is a key component of postlicensure vaccine safety surveillance. Its primary function is to detect early warning signals and generate hypotheses about possible new vaccine adverse events or changes in frequency of known ones. VAERS is a passive surveillance system that relies on physicians and others to voluntarily submit reports of illness after vaccination. Manufacturers are required to report all adverse events of which they become aware. There are a number of well-described limitations of such reporting systems. These include, for example, variability in report quality, biased reporting, underreporting and the inability to determine whether a vaccine caused the adverse event in any individual report. Strengths of VAERS are that it is national in scope and timely. The information in VAERS reports is not necessarily complete nor is it verified systematically. Reports are classified as serious or nonserious based on regulatory criteria. Reports are coded by VAERS in a uniform way with a limited number of terms using a terminology called COSTART. Coding is useful for search purposes but is necessarily imprecise. VAERS is useful in detecting adverse events related to vaccines and most recently was used for enhanced reporting of adverse events in the national smallpox immunization campaign. VAERS data have always been publicly available. However, it is essential for users of VAERS data to be fully aware of the strengths and weaknesses of the system. VAERS data contain strong biases. Incidence rates and relative risks of specific adverse events cannot be calculated. Statistical significance tests and confidence intervals should be used with great caution and not routinely. Signals detected in VAERS should be subjected to further clinical and descriptive epidemiologic analysis. Confirmation in a controlled study is usually required. An understanding of the system's defined objectives and inherent drawbacks is vital to the effective use of VAERS data in vaccine safety investigations.
KW - adverse effects
KW - data collection
KW - human diseases
KW - monitoring
KW - safety
KW - vaccines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - data logging
KW - surveillance systems
KW - Information and Documentation (CC300)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043077008&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Deaths among children less than two years of age receiving palivizumab: an analysis of comorbidities.
AU - Mohan, A. K.
AU - Braun, M. M.
AU - Ellenberg, S.
AU - Hedje, J.
AU - Coté, T. R.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2004///
VL - 23
IS - 4
SP - 342
EP - 345
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Mohan, A. K.: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1404 Rockville Pike, Suite 200S, Bethesda, MD 20852, USA.
N1 - Accession Number: 20043077018. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Background. Palivizumab (Synagis) is used for prophylaxis against respiratory syncytial virus infection among children at high risk for respiratory syncytial virus disease. A number of deaths after palivizumab use among children <2 years have been reported to the Food and Drug Administration. We assessed available information, including the extent to which preexisting medical conditions may have put these children at higher than normal risk of death. Methods. We reviewed reports of deaths to the Food and Drug Administration (June 1998 to December 2001) among children <2 years of age who received palivizumab. Results. There were 133 deaths reported after palivizumab use. Median age at death was 5 months, and 54% of the children were male. At least one congenital anomaly was reported in 85 cases (64%), and 44% of cases had multiple anomalies. Of the 100 cases with reported gestational age at birth, 36% were severely premature (<28 weeks), 48% were moderately premature (28 to 36 weeks) and 16% had normal gestational age. Only 2% of all cases were full term and were born without congenital anomalies; 50% had both conditions, 34% had prematurity alone and 14% had congenital anomalies alone. A cause of death was reported for 88 (66%) cases; most (38%) died from their congenital anomalies or from respiratory infections (23%). Conclusions. Most children dying after palivizumab treatment were at increased risk of death; many had multiple congenital anomalies and/or premature birth. Patterns of outcomes and the reported medical course did not suggest that palivizumab further elevated the risk of death. Current data do not alter the safety and efficacy assessment that led to the licensure of palivizumab.
KW - age
KW - boys
KW - children
KW - congenital abnormalities
KW - epidemiology
KW - girls
KW - human diseases
KW - morbidity
KW - mortality
KW - passive immunity
KW - prematurity
KW - prophylaxis
KW - viral diseases
KW - USA
KW - human respiratory syncytial virus
KW - man
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - death rate
KW - palivizumab
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043077018&site=ehost-live&scope=site
UR - email: mohan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein.
AU - Lian, J. P.
AU - Word, B.
AU - Taylor, S.
AU - Hammons, G. J.
AU - Lyn-Cook, B. D.
JO - Anticancer Research
JF - Anticancer Research
Y1 - 2004///
VL - 24
IS - 1
SP - 133
EP - 138
CY - Attiki; Greece
PB - International Institute of Anticancer Research
SN - 0250-7005
AD - Lian, J. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043211064. Publication Type: Journal Article. Language: English. Registry Number: 446-72-0, 700-06-1. Subject Subsets: Public Health; Human Nutrition
N2 - Background: The signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor required in proliferation and differentiation. STAT3 is activated constitutively in a number of cancers. Materials and Methods: This study was conducted to assess the possible involvement of STAT3 activation in pancreatic cancer and the potential for this pathway as a target in chemopreventive strategy. Results: STAT3 was shown for the first time to be constitutively activated in human pancreatic carcinoma specimens but not in normal pancreatic tissues. Constitutively activated STAT3 was also found in pancreatic tumour cell lines (Panc-1 and MIA PaCa-2) which could be modulated by indole-3-carbinol (13C) and genistein. At concentrations higher than 10 µM, STAT3 constitutive activation is inhibited by both agents. Induction of apoptosis by 13C was also demonstrated. Conclusion: Given its critical role in tumorigenesis, our results suggest that STAT3 activation provides an important and appropriate target for chemoprevention in pancreatic cancer treatment.
KW - chemoprophylaxis
KW - disease prevention
KW - genistein
KW - human diseases
KW - indole-3-methanol
KW - neoplasms
KW - pancreas
KW - pancreatic cancer
KW - signal transduction
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - cancers
KW - indole-3-carbinol
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043211064&site=ehost-live&scope=site
UR - http://www.iiar-anticancer.org/research/research_index.htm
UR - email: Blyncook@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bronchiolitis obliterans syndrome in popcorn production plant workers.
AU - Akpinar-Elci, M.
AU - Travis, W. D.
AU - Lynch, D. A.
AU - Kreiss, K.
JO - European Respiratory Journal
JF - European Respiratory Journal
Y1 - 2004///
VL - 24
IS - 2
SP - 298
EP - 302
CY - Sheffield; UK
PB - European Respiratory Society
SN - 0904-1850
AD - Akpinar-Elci, M.: Division of Respiratory Disease Studies, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Field Studies Branch, MS H-2800, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043131917. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Following sentinel case recognition, an excess of fixed airways obstruction was found among current workers in a microwave popcorn plant associated with butter flavouring exposures [USA; date not given]. In order to characterize the clinical presentation of sentinel cases, the medical records of sentinel cases were reviewed, interviews conducted and serial spirometric testing performed. Cases worked in microwave popcorn production, and five of the nine cases had mixed flavourings. Most had never smoked or smoked minimally. Cases showed onset of cough, shortness of breath and wheezing 5 months to 9 years after starting work at the popcorn plant. Initial forced expiratory volume in one second ranged 14.0%-66.8% of the predicted value. Eight high-resolution computed tomography scans showed marked bronchial wall thickening and mosaic attenuation with air trapping. Open lung biopsy results were consistent with, or diagnostic of, constrictive bronchiolitis in two of three cases. Five cases are on lung transplantation waiting lists. After leaving employment, nearly all cases experienced stabilization of their lung function within 2 years. Astute clinicians can help identify new causes of airways obstruction by alerting public health authorities to unexplained disease cases occurring in groups of workers.
KW - factory workers
KW - flavouring
KW - human diseases
KW - lung function
KW - lungs
KW - occupational hazards
KW - occupational health
KW - respiratory diseases
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bronchiolitis obliterans
KW - flavoring
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043131917&site=ehost-live&scope=site
UR - email: melci@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Electroencephalographic, behavioral, and c-fos responses to acute domoic acid exposure.
AU - Scallet, A. C.
AU - Kowalke, P. K.
AU - Rountree, R. L.
AU - Thorn, B. T.
AU - Binienda, Z. K.
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
Y1 - 2004///
VL - 26
IS - 2
SP - 331
EP - 342
CY - New York; USA
PB - Elsevier Science Inc.
SN - 0892-0362
AD - Scallet, A. C.: Division of Neurotoxicology, National Center for Toxicological Research, USFDA, 3900 NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043056425. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Domoic acid, a potent excitotoxic analogue of glutamate and kainate, may cause seizures, amnesia, and sometimes death in humans consuming contaminated shellfish. Continuous behavioral observations and recordings of the electrocorticogram (ECoG, via bipolar, epidural electrodes) were obtained from nonanesthetized rats for 2 h after intraperitoneal injection with either saline, 2.2, or 4.4 mg/kg of domoic acid. Rats were then sacrificed for c-fos immunohistochemistry. Fast Fourier transformation (FFT) of the ECoG data to obtain the voltage as a function of frequency indicated that the lower frequency bands (theta, 4.75-6.75 Hz and delta, 1.25-4.50 Hz) were the first to respond, with a significant elevation by 30 min after the high dose of domoic acid. The lower dose of domoic acid also caused a significant elevation of ECoG voltage, but not until later in the session. Sixty minutes after dosing, the behavioral biomarkers of "ear scratching" and "rearing, praying" (RP) seizures became significantly elevated in the high-dose rats. The low-dose rats showed no significant alterations in behavior at any time during the session. In postmortem brains obtained immediately after the sessions, c-fos was activated in the anterior olfactory nucleus by both the low and high doses of domoic acid. However, only the high dose increased c-fos immunoreactivity in the hippocampus, affecting both the granule and pyramidal neurons. These data indicate that electroencephalographic and c-fos responses can be obtained at a dose of domoic acid that fails to activate the behavioral response most commonly used as a bioassay for this marine toxin: ear scratching with the ipsilateral foot.
KW - animal models
KW - behaviour
KW - biochemical markers
KW - brain
KW - electroencephalograms
KW - hippocampus
KW - immunohistochemistry
KW - laboratory animals
KW - neurons
KW - neurotoxicity
KW - neurotoxins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - biomarkers
KW - c-fos
KW - cerebrum
KW - domoic acid
KW - nerve cells
KW - neurones
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043056425&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9X-4BSVJ87-1&_user=10&_handle=B-WA-A-A-AY-MsSAYZA-UUW-AUYVVVECBU-AUYWUBUBBU-BCZYYBVWY-AY-U&_fmt=summary&_coverDate=04%2F30%2F2004&_rdoc=16&_orig=browse&_srch=%23toc%235126%232004%23999739997%23484587!&_cdi=5126&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=00f679147f4e8774d2336977c084e62b
UR - email: AScallet@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a broadly reactive nucleic acid sequence based amplification assay for the detection of noroviruses in faecal material.
AU - Moore, C.
AU - Clark, E. M.
AU - Gallimore, C. I.
AU - Corden, S. A.
AU - Gray, J. J.
AU - Westmoreland, D.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2004///
VL - 29
IS - 4
SP - 290
EP - 296
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 1386-6532
AD - Moore, C.: National Public Health Service for Wales Microbiology Cardiff, Specialist Virology Centre, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK.
N1 - Accession Number: 20043059123. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - A recently described nucleic acid sequence based amplification (NASBA) assay for the detection of genogroup I (GI) and genogroup II (GII) norovirus RNA in faecal samples was evaluated against a reverse transcription polymerase chain reaction (RT-PCR). Both assays were used to screen a panel of 38 faecal samples known to contain 17 different norovirus strains and 131 clinical samples collected from 60 gastroenteritis outbreaks of unknown aetiology. The NASBA assay detected 13 out of the 17 strains of norovirus in the characterised panel, failing to detect a single GII strain and three GI strains. There was 90% agreement between the two assays used to detect norovirus in clinical samples from outbreaks. NASBA detected norovirus RNA in all 64 samples positive by RT-PCR and also detected norovirus RNA in additional 13 samples that were negative by RT-PCR. The sensitivity and specificity of NASBA was 100% and 80%, respectively, compared to RT-PCR results. The norovirus NASBA assay was shown to be highly sensitive and specific, and its ease of use and rapid turnaround time makes it a favourable alternative to RT-PCR for the investigation of norovirus outbreaks.
KW - assays
KW - diagnosis
KW - diagnostic techniques
KW - epidemiology
KW - faeces
KW - gastroenteritis
KW - human diseases
KW - nucleotide sequences
KW - outbreaks
KW - polymerase chain reaction
KW - UK
KW - Caliciviridae
KW - man
KW - Norovirus
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - DNA sequences
KW - feces
KW - PCR
KW - United Kingdom
KW - winter vomiting disease
KW - winter vomiting virus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043059123&site=ehost-live&scope=site
UR - email: catherine.moore@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Polyarteritis nodosa reports to the vaccine adverse event reporting system (VAERS): implications for assessment of suspected vaccine-provoked vasculitis.
AU - Begier, E. M.
AU - Langford, C. A.
AU - Sneller, M. C.
AU - Wise, R. P.
AU - Ball, R.
T2 - Journal of Rheumatology
JO - Journal of Rheumatology
JF - Journal of Rheumatology
Y1 - 2004///
VL - 31
IS - 11
SP - 2181
EP - 2188
CY - Toronto; Canada
PB - Journal of Rheumatology Publishing Co Ltd
SN - 0315-162X
AD - Begier, E. M.: Vaccine Safety Branch, Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20043209574. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - Objective. To examine polyarteritis nodosa (PAN) reports to the Vaccine Adverse Event Reporting System (VAERS) as the initial stage in investigating the hypothesis that vaccination can very rarely cause PAN. Methods. We reviewed PAN reports submitted from 1990 through 2001 using a causal inference framework to evaluate the consistency of the reports' clinical details with this hypothesis. We also reviewed published literature relating to the hypothesized association's biological plausibility. Results. VAERS received 25 PAN reports. Ten met our case definition for definite or possible PAN and had no alternative aetiology for PAN identified. Nine of these 10 followed hepatitis B vaccine with a modal peak (4 definite cases) in time to symptom onset 2 weeks after vaccination. However, all potential triggering infections were not excluded, and identification of vaccine antigens in clinical specimens was not attempted. Also, 14 of 25 reports were European, with 11 from France. All 9 French reports with a known diagnosis date began during 1994-97, when autoimmune and rheumatologic events following hepatitis B vaccine were a focus of public concern in France. Conclusion. While we identified some supportive evidence, overall, current adverse event reports do not support a causal link between vaccination and PAN. Appropriate prospective evaluation of future post-vaccination PAN cases could add to current knowledge with rigorous confirmation of diagnosis, appropriate testing for possible triggering infections including polymerase chain reaction testing for latent hepatitis B infection, and an attempt to link the vaccine antigen to pathology such as by immunohistochemical staining or immune complex identification.
KW - adverse effects
KW - epidemiology
KW - hepatitis B
KW - human diseases
KW - immunization
KW - vaccination
KW - vaccines
KW - vasculitis
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - immune sensitization
KW - polyarteritis nodosa
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043209574&site=ehost-live&scope=site
UR - http://jrheum.com/subscribers/04/11/2181.html
UR - email: ballr@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Respiratory protection against bioaerosols: literature review and research needs.
AU - Rengasamy, A.
AU - Zhuang, Z. Q.
AU - BerryAnn, R.
JO - American Journal of Infection Control
JF - American Journal of Infection Control
Y1 - 2004///
VL - 32
IS - 6
SP - 345
EP - 354
CY - St Louis; USA
PB - Mosby Inc.
SN - 0196-6553
AD - Rengasamy, A.: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Bruceton, PA 15236, USA.
N1 - Accession Number: 20053138022. Publication Type: Journal Article. Language: English. Number of References: 87 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Research on respiratory protection against biologic agents is important to address major concerns such as occupational safety and terrorist attack. This review describes the literature on respiratory protection against bioaerosols and identifies research gaps. Respiratory protection is a complex field involving a number of factors, such as the efficiency of respirator filter material; face-piece fitting; and maintenance, storage, and reuse of respirators. Several studies used nonpathogenic microorganisms having physical characteristics similar to that of Mycobacterium tuberculosis to analyze microbial penetration through respirators. Some studies showed that high-efficiency particulate air (HEPA) and N95 filters provided a higher level of protection than dust/mist (DM) and dust/mist/fume (DMF) filters. Flow rate and relative humidity appear to alter the level of penetration of microorganisms through respirator filters. The relationship between microbial penetration through respirator filters and the aerodynamic diameter, length, or other physical characteristics of microorganisms remains controversial. Whether reaerosolization of bioaerosol particles should be a concern is unclear, given the fact that one study has demonstrated significant reaerosolization of 1- to 5-µm particles loaded onto respirator filters. Respirator maintenance, storage, and decontamination are important factors to be considered when reusing respirators. The respiratory protection against biologic warfare agents such as anthrax in military and civilian situations is described.
KW - aerosols
KW - airborne infection
KW - bacterial diseases
KW - bioterrorism
KW - disease prevention
KW - disinfectants
KW - disinfection
KW - equipment
KW - exposure
KW - human diseases
KW - mycoses
KW - respiratory diseases
KW - reviews
KW - terrorism
KW - tuberculosis
KW - viral diseases
KW - bacteria
KW - fungi
KW - man
KW - Mycobacterium tuberculosis
KW - viruses
KW - prokaryotes
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - lung diseases
KW - respirators
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053138022&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4DDPYXN-C&_user=3891418&_handle=V-WA-A-W-WW-MsSAYZA-UUW-U-AAWZWZDDZD-AAWBYVYCZD-WDCECEBEC-WW-U&_fmt=summary&_coverDate=10%2F01%2F2004&_rdoc=7&_orig=browse&_srch=%23toc%236686%232004%23999679993%23521473!&_cdi=6686&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=4644110338b32eb9318a849b98438bdd
UR - email: rda5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Structuring a multi-site evaluation for youth mentoring programs to prevent teen alcohol and drug use.
AU - Bellamy, N. D.
AU - Springer, U. F.
AU - Sale, E. W.
AU - Espiritu, R. C.
JO - Journal of Drug Education
JF - Journal of Drug Education
Y1 - 2004///
VL - 34
IS - 2
SP - 197
EP - 212
CY - Amityville; USA
PB - Baywood Publishing Company Inc.
SN - 0047-2379
AD - Bellamy, N. D.: Substance Abuse and Mental Health Services Administration, Rm 12-105, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20053049497. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Despite mentoring's rapidly increasing popularity as an intervention for the prevention of teen alcohol and drug abuse and associated problems, there is little research consensus on its overall effectiveness or on the core principles and components that define effective mentoring. To advance knowledge concerning this important prevention intervention, the Center for Substance Abuse Prevention has designed and funded a multi-site cooperative agreement involving seven mentoring programs. The programs are designed to provide a rigorous outcome evaluation that allows comparisons of differing approaches to organizing and delivering mentoring services to adolescents at high risk for substance abuse. The cooperative agreement guidelines set service parameters and options that focus on issues that are grounded in past research on mentoring prevention interventions. The cooperative agreement includes a quasi-experimental, longitudinal multi-site evaluation that provides evidence-based recommendations to advance the effective use of mentoring as a prevention strategy.
KW - adolescents
KW - alcohol intake
KW - alcoholic beverages
KW - alcoholism
KW - children
KW - controlled substances
KW - disease prevention
KW - drug abuse
KW - human diseases
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - drug use
KW - drugs (controlled substances)
KW - health programmes
KW - teenagers
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049497&site=ehost-live&scope=site
UR - http://baywood.metapress.com/app/home/contribution.asp?wasp=309e0e5103f64baa93dc1ff92004f2b2&referrer=parent&backto=issue,7,7;journal,2,135;linkingpublicationresults,1:300320,1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Depressive disorder as a long-term antecedent risk factor for incident back pain: a 13-year follow-up study from the Baltimore Epidemiological Catchment Area Sample.
AU - Larson, S. L.
AU - Clark, M. R.
AU - Eaton, W. W.
JO - Psychological Medicine
JF - Psychological Medicine
Y1 - 2004///
VL - 34
IS - 2
SP - 211
EP - 219
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0033-2917
AD - Larson, S. L.: Agency for Healthcare Research and Quality (AHQR), Centre for Cost and Financing Studies, Access and Cost Trends, Division of Social and Economic Research (CFACT-DSER), 540 Gaither Road, Suite 5000, Rockville, MD 20850, USA.
N1 - Accession Number: 20043025191. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Background: The co-occurrence of affective distress and back pain is well documented but the relationship between them is less certain. This study examines the relationship between lifetime occurrence of depressive disorder and incident back pain reported over a 13-year period. Method: The Baltimore Epidemiologic Catchment Area Study is a prospective study of a household-residing cohort, selected probabilistically from East Baltimore, Maryland, USA in 1981. Between 1982-3 (wave 2) and again between 1993-6 (wave 3), a follow-up study of the original cohort was conducted. Questions on depressive disorder and back pain were drawn from the Diagnostic Interview Schedule. Logistic regression analyses were used to evaluate whether depressive disorder acts as a risk factor for incident back pain. Results: In cross-sectional analyses, lifetime occurrence of depressive disorder was a significant correlate of lifetime prevalence of back pain at wave 1 (OR=1.6, P=0.01). During the 13-year follow-up, across three data collection points, there was an increase in the risk for incident back pain when depressive disorder was present at baseline (OR=1.9, 95% CI 1.03, 3.4). However, during the short-term follow-up period of one year, between baseline and wave 2, depressive disorder at baseline was unrelated to first-ever reports of back pain. Lifetime depressive disorder in both waves 1 (baseline) and 2 (one year later) was associated with a more than three times greater risk for a first-ever report of back pain during the 12 to 13 year follow-up period, in comparison to those who did not have depressive disorder at waves 1 or 2 (OR=3.4, 95% CI 1.4, 7.8). Back pain at wave 1 was not significantly associated with an increased risk for depression in the longitudinal analysis (OR=0.8, 95% CI 0.5, 1.4). Conclusions: Depressive disorder appears to be a risk factor for incident back pain independent of other characteristics often associated with back pain. Back pain is not a short-term consequence of depressive disorder but emerges over periods longer than one year. Moreover, in this study the alternative pathway of back pain as a risk factor for depressive disorder could not be supported.
KW - back
KW - depression
KW - human diseases
KW - mental disorders
KW - pain
KW - risk
KW - risk factors
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - mental illness
KW - psychiatric disorders
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043025191&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human health impact from antimicrobial use in food animals.
AU - Tollefson, L.
AU - Karp, B. E.
JO - Médecine et Maladies Infectieuses
JF - Médecine et Maladies Infectieuses
Y1 - 2004///
VL - 34
IS - 11
SP - 514
EP - 521
CY - Paris; France
PB - Éditions Scientifiques et Médicales Elsevier SAS
SN - 0399-077X
AD - Tollefson, L.: Center for Veterinary Medicine, US Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20043208836. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 79 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - There is accumulating evidence that the use of antimicrobials in food-producing animals has adverse human health consequences. The use of antibiotics in food animals selects for resistant pathogens and resistance genes that may be transferred to humans through the consumption or handling of foods of animal origin. Recent studies have demonstrated that antimicrobial-resistance among foodborne bacteria may cause excess cases of illness, prolonged duration of illness, and increased rates of bacteraemia, hospitalization, and death. The continued availability of safe and effective antimicrobials for humans and animals depends upon the responsible use of these products.
KW - antibiotics
KW - antiinfective agents
KW - drug residues
KW - drug resistance
KW - drug therapy
KW - food contamination
KW - foodborne diseases
KW - pathogens
KW - antimicrobials
KW - chemotherapy
KW - food contaminants
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043208836&site=ehost-live&scope=site
UR - email: ltollefs@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high-performance liquid chromatography with fluorescence detection.
AU - Idowu, O. R.
AU - Peggins, J. O.
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
Y1 - 2004///
VL - 35
IS - 1
SP - 143
EP - 153
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0731-7085
AD - Idowu, O. R.: US Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043059700. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 85721-33-1, 93106-60-6. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science
N2 - A rapid and simple procedure for determination of enrofloxacin and ciprofloxacin in bovine milk and plasma is described. Protein precipitation from both milk and plasma samples was achieved by addition of acetonitrile and phosphoric acid. Acetonitrile was removed with methylene chloride, leaving enrofloxacin and ciprofloxacin in the acidic aqueous extract. The aqueous extract was analyzed by high-performance liquid chromatography (HPLC) with fluorescence detection. The limit of quantitation (LOQ) for enrofloxacin and ciprofloxacin in milk was found to be 2 ng/ml. LOQ for enrofloxacin and ciprofloxacin in plasma was found to be 1 ng/ml. Linear calibration curves were obtained with correlation coefficient (r2) ≥0.99. Analysis of quality control (QC) samples gave results within ±10% of the nominal values. Inter-assay precision for the analysis of milk QC samples were in the ranges: 4.63-12.49% (for enrofloxacin) and 4.67-9.86% (for ciprofloxacin). Inter-assay precision for the analysis of plasma QC samples were in the ranges: 6.60-17.31% (for enrofloxacin) and 6.14-13.87% (for ciprofloxacin). Intra-assay precision for the analysis of milk QC samples were in the following ranges: 3.65-7.21% (for enrofloxacin) and 1.58-14.28% (for ciprofloxacin). Intra-assay precision for the analysis of plasma QC samples were in the following ranges: 2.17-16.95% (for enrofloxacin) and 3.31-16.31% (for ciprofloxacin). The effectiveness of protein precipitants other than phosphoric acid was investigated. The method described has been applied to a study of the pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers.
KW - antibacterial agents
KW - ciprofloxacin
KW - determination
KW - drug residues
KW - enrofloxacin
KW - fluorescence
KW - HPLC
KW - milk
KW - rapid methods
KW - high performance liquid chromatography
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043059700&site=ehost-live&scope=site
UR - email: oidowu@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative influences on recent changes in the first birth ratio in the United States.
AU - King, R. B.
JO - Journal of Biosocial Science
JF - Journal of Biosocial Science
Y1 - 2004///
VL - 36
IS - 1
SP - 1
EP - 17
CY - Colchester; UK
PB - Biochemical Society
SN - 0021-9320
AD - King, R. B.: Demographic and Behavioral Sciences Branch, Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, USA.
N1 - Accession Number: 20043052919. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Researchers in psychology have focused a great deal of attention on the potential greater predisposition to achievement among first-born children relative to their siblings. Focusing on the United States as an example, a time series of the first birth ratio is used to show how the changing prevalence of first births relative to higher order births has altered the composition of birth cohorts, and the ratio is decomposed into four factors. Results show that the ratio increased significantly in the 1960s and early 1970s, but changed only slightly in the following decades. While more recent birth cohorts are composed of larger proportions of first-born children, the majority of children are still born as siblings. Contrary to expectations, the primary source of change was the proportion childless rather than decreasing higher order birth rates.
KW - birth
KW - birth rate
KW - children
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043052919&site=ehost-live&scope=site
UR - http://titles.cambridge.org/journals/journal_article.asp?mnemonic=JBS&pii=S0021932004006029
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: an update.
AU - Lard-Whiteford, S. L.
AU - Matecka, D.
AU - O'Rear, J. J.
AU - Yuen, I. S.
AU - Litterst, C.
AU - Reichelderfer, P.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2004///
VL - 36
IS - 1
SP - 541
EP - 552
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Lard-Whiteford, S. L.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20043085649. Publication Type: Journal Article. Language: English. Number of References: 85 ref. Subject Subsets: Public Health
N2 - The development of methods to prevent HIV infection is critical to curbing the rising epidemic. Topical microbicides represent a potential new strategy for reduction of HIV transmission. The purpose of this article is to update and expand upon the nonclinical recommendations of a previously published document on the development of microbicides prepared by the International Working Group on Microbicides. The nonclinical studies discussed here represent general concepts and regulatory considerations that are pertinent to the development of topical microbicides for prevention or reduction of HIV transmission. Essential early steps in product development include the determination of antiviral activity, cytotoxicity, mechanism of action, pathways to resistance, and cross-resistance to approved drugs. Other parameters to consider include activity against vaginal microflora and pathogens that cause sexually transmitted diseases. Before and during clinical trials, nonclinical data on toxicology and pharmacokinetics should be obtained. Finally, product quality issues, including microbicide formulation characteristics, interaction with other products, and stability, should be addressed.
KW - antiviral properties
KW - cross resistance
KW - cytotoxicity
KW - disease prevention
KW - disease transmission
KW - drug development
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - microbial flora
KW - pathogens
KW - pharmacodynamics
KW - pharmacokinetics
KW - sexually transmitted diseases
KW - topical application
KW - toxicology
KW - vagina
KW - viral diseases
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - anti-viral properties
KW - drug action
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mechanism of drug action
KW - microbicides
KW - microflora
KW - STDs
KW - venereal diseases
KW - viral infections
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043085649&site=ehost-live&scope=site
UR - email: yueni@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC-ESI-MS and LC-UV.
AU - Gratz, S. R.
AU - Flurer, C. L.
AU - Wolnik, K. A.
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
Y1 - 2004///
VL - 36
IS - 3
SP - 525
EP - 533
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0731-7085
AD - Gratz, S. R.: US Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA.
N1 - Accession Number: 20043207001. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9025-82-5. Subject Subsets: Human Nutrition
N2 - A liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) method was developed to screen for the presence of synthetic phosphodiesterase type 5 (PDE-5) inhibitors including sildenafil, tadalafil and vardenafil. The method was applied to the analysis of dietary supplements and bulk herbal materials. Bulk powders or composites of tablets, capsules or liquids were prepared and an extraction of PDE-5 inhibitors was performed using a mixture of acetonitrile and water with sonication. Identification of sildenafil, vardenafil or tadalafil was accomplished using a single quadrupole mass spectrometer coupled to a liquid chromatograph with an electrospray interface. Positive ion detection in the full scan mode was used while in-source collision induced dissociation (CID) provided several structurally significant fragment ions to aid in the mass spectral identification. Approximately half of the 40 botanical products analyzed were found to contain undeclared synthetic PDE-5 inhibitors. For products found to contain one of these three compounds by LC-MS, HPLC with UV detection was used for quantitation.
KW - analytical methods
KW - drugs
KW - enzyme inhibitors
KW - food supplements
KW - liquid chromatography
KW - mass spectrometry
KW - phosphodiesterase I
KW - analytical techniques
KW - medicines
KW - pharmaceuticals
KW - sildenafil
KW - tadalafil
KW - vardenafil
KW - Physiology of Human Nutrition (VV120)
KW - Pharmacology (VV730) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043207001&site=ehost-live&scope=site
UR - email: sgratz@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Francisella tularensis genes encoding exported membrane-associated proteins using TnphoA mutagenesis of a genomic library.
AU - Gilmore, R. D., Jr.
AU - Bacon, R. M.
AU - Sviat, S. L.
AU - Petersen, J. M.
AU - Bearden, S. W.
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2004///
VL - 37
IS - 4
SP - 205
EP - 213
CY - Oxford; UK
PB - Elsevier
SN - 0882-4010
AD - Gilmore, R. D., Jr.: Microbiology and Pathogenesis Laboratory, Bacterial Zoonoses Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, P.O. Box 2087, Rampart Rd, Foothills Campus, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053150947. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Francisella tularensis, the causative agent of tularaemia, is a highly infectious pathogen of humans and animals, yet little is known about the surface proteins of this organism that mediate mechanisms of pathogenicity. λTnphoA was used to generate random alkaline phosphatase gene fusions in a F. tularensis subsp. tularensis (strain Schu S4) genomic library to identify genes encoding exported extracytoplasmic proteins. Eleven genes encoding membrane-associated proteins were identified by this method and their respective signal peptides were characterized. Three of the genes encoded conserved 'housekeeping' enzymes, while the other eight genes were unique to F. tularensis, encoding proteins with molecular masses ranging from 11 to 78 kDa as deduced from the amino acid sequences. Two genes putatively encoded lipoproteins based on the presence of characteristic signal peptidase II cleavage sites. Four selected proteins were found associated with outer membranes from Schu S4 and LVS strains by Western blotting. Indirect immunofluorescence of strain Schu S4 cells also showed evidence of protein localization to the outer membrane. Protein database searches produced significant alignments with proteins from other bacteria involved in carbohydrate transport, lipid metabolism, and cell envelope biogenesis, thereby providing clues for putative functions. These findings demonstrated that TnphoA mutagenesis can be used in conjunction with F. tularensis genome sequence data to provide a foundation for studies to identify and define cellular surface protein virulence factors of this pathogen.
KW - amino acid sequences
KW - bacterial proteins
KW - enzymes
KW - gene expression
KW - genes
KW - genome analysis
KW - genomes
KW - molecular genetics
KW - signal peptide
KW - surface proteins
KW - Francisella tularensis
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - membrane proteins
KW - protein sequences
KW - signal sequence
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053150947&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN6-4DBSV92-2&_user=3891418&_handle=V-WA-A-W-Z-MsSAYZA-UUW-U-AAWYCUBVEA-AAWZUYVWEA-BWUABDBDC-Z-U&_fmt=summary&_coverDate=10%2F01%2F2004&_rdoc=5&_orig=browse&_srch=%23toc%236954%232004%23999629995%23521862!&_cdi=6954&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=b8275a4f76e49ae10c406e2409978b8f
UR - email: rbg9@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Postmarketing safety surveillance for typhoid fever vaccines from the Vaccine Adverse Event Reporting System, July 1990 through June 2002.
AU - Begier, E. M.
AU - Burwen, D. R.
AU - Haber, P.
AU - Ball, R.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004///
VL - 38
IS - 6
SP - 771
EP - 779
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Begier, E. M.: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20043067218. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - Vaccines against Salmonella enterica serotype Typhi are used for prophylaxis of international travelers and have potential use as counterbioterrorism agents. The Vaccine Adverse Event Reporting System (VAERS) cannot usually establish causal relationships between vaccines and reported adverse events without further research but has successfully detected unrecognized side effects of vaccine. We reviewed reports to VAERS for US-licensed typhoid fever vaccines for the period of July 1990 through June 2002. We received 321 reports for parenteral Vi capsular polysaccharide vaccine and 345 reports for live, oral, attenuated Ty21a vaccine, with 7.5% and 5.5%, respectively, describing death, hospitalization, permanent disability, or life-threatening illness. Unexpected frequently reported symptoms included dizziness and pruritus for Vi vaccine and fatigue and myalgia for Ty21a vaccine. Gastroenteritis-like illness after receipt of Ty21a vaccine and abdominal pain after receipt of Vi vaccine, which are previously recognized events, occasionally required hospitalization. Nonfatal anaphylaxis was reported after both vaccines. VAERS reports do not indicate any unexpected serious side effects that compromise these vaccines' use for travelers' prophylaxis.
KW - adverse effects
KW - disease control
KW - health protection
KW - human diseases
KW - immunization
KW - live vaccines
KW - travellers
KW - typhoid
KW - vaccination
KW - Salmonella typhi
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - adverse reactions
KW - attenuated vaccines
KW - bacterium
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043067218&site=ehost-live&scope=site
UR - email: ballr@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trans, saturated, and unsaturated fat in foods in the United States prior to mandatory trans-fat labeling.
AU - Satchithanandam, S.
AU - Oles, C. J.
AU - Spease, C. J.
AU - Brandt, M. M.
AU - Yurawecz, M. P.
AU - Rader, J. I.
JO - Lipids
JF - Lipids
Y1 - 2004///
VL - 39
IS - 1
SP - 11
EP - 18
CY - Champaign; USA
PB - AOCS Press
SN - 0024-4201
AD - Satchithanandam, S.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, U.S. Food and Drug Administration, HFS-840, 5100 Paint Branch Pkwy., College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043042773. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Potatoes; World Agriculture, Economics & Rural Sociology; Human Nutrition; Horticultural Science
N2 - The purpose of this study was to determine the trans-fatty acid (FA) content of a wide range of foods prior to the effective date (1 January 2006) of the new regulation on declaration of trans-FA in nutrition labels of conventional foods and dietary supplements. AOAC Official Method of Analysis 996.01 was modified for the analysis of trans-FA in noncereal products. Food products for analysis were selected on the basis of market share and data from the USDA's 1994-1996 Continuing Survey of Food Intake by Individuals. Foods were purchased from local supermarkets, weighed, hydrolysed, converted to FAME (fatty acid methyl ester), and analysed by GC. The results showed that trans-FA (g/100 g fat) ranged from 0.0-48.8 in bread, cake, and related products; from 14.9-27.7 in margarines; from 7.7-35.3 in cookies and crackers; from 24.7-38.2 in frozen potatoes; from 0.0-17.1 in salty snacks; from 0.0-13.2 in vegetable oils and shortenings; from 0.0-2.2 in salad dressings and mayonnaise; and from 0.0-2.0 in dry breakfast cereals. Serving sizes for the foods included in this survey ranged from 12-161 g, and trans-FA levels ranged from 0.0-7.2 g/serving. The significant differences in trans-FA content in products within each food category are due to differences in the type of fats and oils used in the manufacturing processes.
KW - bakery products
KW - bread
KW - breakfast cereals
KW - cakes
KW - cookies
KW - crackers
KW - food composition
KW - labelling
KW - margarine
KW - nutrition labeling
KW - plant oils
KW - portion size
KW - potatoes
KW - regulations
KW - salad dressings
KW - saturated fatty acids
KW - snacks
KW - trans fatty acids
KW - unsaturated fatty acids
KW - USA
KW - Solanum tuberosum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baked goods
KW - labeling
KW - labels
KW - rules
KW - United States of America
KW - vegetable oils
KW - Laws and Regulations (DD500)
KW - Marketing and Distribution (EE700)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043042773&site=ehost-live&scope=site
UR - email: Ssubrama@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Synthesis, isolation, and GC analysis of all the 6,8- to 13,15-cis/trans conjugated linoleic acid isomers.
AU - Delmonte, P.
AU - Roach, J. A. G.
AU - Mossoba, M. M.
AU - Losi, G.
AU - Yurawecz, M. P.
JO - Lipids
JF - Lipids
Y1 - 2004///
VL - 39
IS - 2
SP - 185
EP - 191
CY - Champaign; USA
PB - AOCS Press
SN - 0024-4201
AD - Delmonte, P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-840, College Park, MD 20740, USA.
N1 - Accession Number: 20043071238. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 7553-56-2, 60-33-3, 463-40-1, 14701-21-4, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition
N2 - Octadecadienoic acids with conjugated double bonds are often referred to as conjugated linoleic acid (CLA). CLA is of considerable interest because of potentially beneficial effects reported from animal studies. Analysis of CLA is usually carried out by gas chromatography (GC) elution of fatty acid methyl ester (FAME). If the presence of low-level isomers is of interest, a complementary technique such as silver ion HPLC is also used. These analyses have been hindered by a lack of well-characterized commercially available reference materials. Described here are the synthesis and isolation of selected 6,8- through 13,15-positional CLA isomers, followed by isomerization of these CLA isomers with iodine to produce all the possible cis,cis, cis,trans, trans,cis, and trans,trans combinations. Also present are the GC retention times of the CLA FAME relative to γ-linolenic acid (6c,9c,12c-octadecatrienoic acid) FAME using a 100-m CP Sil-88 capillary column (Varian Inc., Lake Forest, CA). These data include all the CLA isomers that have been identified thus far in foods and dietary supplements and should greatly aid in the future analysis of CLA in these products.
KW - analytical methods
KW - conjugated linoleic acid
KW - fatty acids
KW - food supplements
KW - foods
KW - gas chromatography
KW - HPLC
KW - iodine
KW - isolation
KW - isomerization
KW - isomers
KW - linoleic acid
KW - linolenic acid
KW - silver ions
KW - synthesis
KW - analytical techniques
KW - fatty acid methyl ester
KW - high performance liquid chromatography
KW - octadecadienoic acid
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043071238&site=ehost-live&scope=site
UR - email: mpy@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis following the use of etanercept, a tumor necrosis factor inhibitor.
AU - Mohan, A. K.
AU - Coté, T. R.
AU - Block, J. A.
AU - Manadan, A. M.
AU - Siegel, J. N.
AU - Braun, M. M.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004///
VL - 39
IS - 3
SP - 295
EP - 299
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Mohan, A. K.: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1404 Rockville Pike, Ste. 200S, Bethesda, MD 20852, USA.
N1 - Accession Number: 20043154858. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 308079-78-9. Subject Subsets: Tropical Diseases
N2 - Infliximab, a tumor necrosis factor (TNF) antagonist, is associated with tuberculosis (TB), but it is unknown whether this phenomenon is true of all TNF antagonists. We reviewed 25 cases of TB due to another TNF antagonist, etanercept, that were reported to the US Food and Drug Administration (FDA) between November 1998 and March 2002. Such cases are sometimes incomplete and are subject to underreporting. Fifteen patients received other immunosuppressive medications. The median interval between the receipt of the first dose of etanercept and the diagnosis of TB was 11.5 months. Thirteen patients had extrapulmonary TB at the time of diagnosis. Diagnosis was made on the basis of culture results for 12 patients, biopsy findings for 9, and sputum staining for 4. There were 2 deaths, 1 of which was directly attributed to TB. The estimated number of TB cases reported to the FDA for each person-year of treatment with etanercept (i.e., the "reporting rate") among patients with rheumatoid arthritis (RA) was ~10 cases/100 000 patient-years of exposure. Clinicians considering etanercept for patients with RA should be alert to the possibility of the occurrence of TB, sometimes with an unusual extrapulmonary presentation. It is unclear whether etanercept therapy increases the risk of TB beyond the elevated TB rates already documented for patients with RA.
KW - antagonists
KW - diagnosis
KW - epidemiology
KW - extrapulmonary tuberculosis
KW - human diseases
KW - immunosuppressive agents
KW - mortality
KW - mycobacterial diseases
KW - rheumatoid arthritis
KW - tuberculosis
KW - tumour necrosis factor
KW - Europe
KW - India
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Commonwealth of Nations
KW - Developing Countries
KW - South Asia
KW - Asia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - cachectin
KW - cachexin
KW - death rate
KW - etanercept
KW - immunosuppressants
KW - infliximab
KW - mycobacterial infections
KW - tumor necrosis factor
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043154858&site=ehost-live&scope=site
UR - email: mohan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US Food and Drug Administration approval of ciprofloxacin hydrochloride for management of postexposure inhalational anthrax.
AU - Meyerhoff, A.
AU - Albrecht, R.
AU - Meyer, J. M.
AU - Dionne, P.
AU - Higgins, K.
AU - Murphy, D.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004///
VL - 39
IS - 3
SP - 303
EP - 308
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Meyerhoff, A.: US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20043154859. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 85721-33-1. Subject Subsets: Public Health
N2 - In August 2000, the US Food and Drug Administration (FDA) approved ciprofloxacin hydrochloride (Cipro; Bayer) for management of postexposure inhalational anthrax. This was the first antimicrobial drug approved by the FDA for use in treating an infection due to a biological agent used intentionally. The terrorist attacks of 2001 involving anthrax underscore the imperative that safe and effective drugs to manage such infections be readily available in the United States. The approval of ciprofloxacin hydrochloride, which was made on the basis of a surrogate human marker of efficacy, made extensive use of data from an animal model of disease. This represents a new direction in the development of efficacy data in support of drug approval and facilitates the availability of those drugs for which there is an urgent need. This article presents the scientific data and regulatory mechanism that supported the approval of ciprofloxacin hydrochloride for management of postexposure of inhalational anthrax.
KW - anthrax
KW - antibacterial agents
KW - antiinfective agents
KW - bacterial diseases
KW - ciprofloxacin
KW - drug therapy
KW - drugs
KW - human diseases
KW - terrorism
KW - USA
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antimicrobials
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - ciprofloxacin hydrochloride
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043154859&site=ehost-live&scope=site
UR - email: am282@gunet.georgetown.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Issues in clinical trials of prophylaxis of fungal infections.
AU - Powers, J. H.
A2 - Rex, J. H.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004///
VL - 39
SP - S211
EP - S217
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Powers, J. H.: Antimicrobial Drug Development and Resistance Initiatives, Center for Drug Evaluation and Research, US Food and Drug Administration, 9201 Corporate Blvd., HFD-104, Rockville, MD 20850, USA.
N1 - Accession Number: 20043197024. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 22 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - The validity of the results of a clinical trial is highly dependent upon the design of the trial. The definition of disease, the selection criteria for enrollment in the trial, the selection of the study and control drugs, and the end points all affect whether the information obtained from the trial ultimately is useful in making decisions in clinical practice. These factors all apply to the design of clinical trials of the prophylaxis of infectious diseases. In addition, prophylaxis trials have several important differences from the design of trials of the treatment of those same diseases. The risk-benefit analysis for trials of prophylaxis is different, in that asymptomatic patients are exposed to the drug and more patients will be exposed than will develop the disease under study. Standardization of the design of such clinical trials will allow more efficient development of new drugs and will allow clinicians to compare more accurately the safety and efficacy of prophylactic agents.
KW - antifungal agents
KW - clinical trials
KW - drug development
KW - experimental design
KW - human diseases
KW - mycoses
KW - reviews
KW - risk assessment
KW - standardization
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fungistats
KW - plot design
KW - Research (AA500)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043197024&site=ehost-live&scope=site
UR - email: powersjoh@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Considerations in clinical trials of combination antifungal therapy.
AU - Powers, J. H.
A2 - Rex, J. H.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004///
VL - 39
SP - S228
EP - S235
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Powers, J. H.: Antimicrobial Drug Development and Resistance Initiatives, Center for Drug Evaluation and Research, US Food and Drug Administration, 9201 Corporate Blvd., HFD-104, Rockville, MD 20850, USA.
N1 - Accession Number: 20043197027. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 40 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - The cure rate for serious fungal diseases with currently available agents used as monotherapy is not optimal. The introduction of new classes of antifungal drugs in the last few years naturally leads to the hypothesis that antifungal drugs used in combination may be more effective than the same drugs used alone. The design and interpretation of combination therapy studies raise challenges beyond those encountered when drugs are studied as monotherapy in the treatment of a disease. The definition of combination therapy, the study design, the selection of appropriate patient populations, and the selection of end points, as well as practical considerations, are all important in the design and interpretation of clinical trials of combination therapies. Although combination therapies hold the promise of improved efficacy, it is important to prove this hypothesis, because they also may be associated with increased toxicity and increased drug costs. A careful consideration of study design factors before the initiation of a trial will help obtain the most useful information for patients in this important area.
KW - adverse effects
KW - antifungal agents
KW - clinical trials
KW - experimental design
KW - human diseases
KW - multiple drug therapy
KW - mycoses
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - combination drug therapy
KW - fungistats
KW - plot design
KW - Research (AA500)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043197027&site=ehost-live&scope=site
UR - email: powersjoh@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An intervention analysis for the reduction of exposure to methylmercury from the consumption of seafood by women of child-bearing age.
AU - Carrington, C. D.
AU - Montwill, B.
AU - Bolger, P. M.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2004///
VL - 40
IS - 3
SP - 272
EP - 280
CY - Orlando; USA
PB - Academic Press
SN - 0273-2300
AD - Carrington, C. D.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20043215961. Publication Type: Journal Article. Language: English. Registry Number: 593-74-8. Subject Subsets: Public Health; Human Nutrition
N2 - A previously developed exposure model was used [Risk Anal. 22 (2002) 689] to assess the effectiveness of various advisory scenarios on minimizing mercury (Hg) blood levels via the consumption of commercial seafood, both finfish and shellfish. This exposure model was developed to predict levels of Hg in blood in women of child-bearing age in the US based on the frequency of seafood consumption, the amount of seafood consumed per serving, and the types of seafood consumed. Steady-state relationships that employed descriptive statistics to account for toxicokinetic variation were used to predict levels of Hg in blood. The model incorporates an uncertainty dimension that is intended to represent the range of plausible interpretations of the data. The predictability of the model was confirmed via the use of National Health and Nutrition Examination Survey (NHANES) blood Hg data. In the present analysis, the model was used to predict the impact of limitations in the amount or types of seafood consumed on blood Hg levels. Specifically, simulations for various advisory scenarios were developed on the basis of limitations on total consumption of seafood, elimination of the consumption of certain species altogether, and/or a combination of both. In the baseline model, the median (uncertainty) estimates for the 50th, 95th, and 99th per capita population percentiles were 1.25, 8.2, and 16.1 ppb blood Hg, respectively. After restriction of seafood consumption to no more than 12 oz/week, the median (uncertainty) estimates for the 50th, 95th, and 99th per capita population percentiles were 1.22, 6.8, and 10.6 ppb blood Hg, respectively. Elimination of MeHg species, with average concentrations above 0.6 ppm, resulted in very modest decrements in Hg blood levels, in comparison to either the baseline or the reduced consumption scenarios. These results suggest that strategies to reduce MeHg exposure by reducing the amount of fish consumed (e.g., 12 oz/week) are more effective at eliminating the high end of the exposure distribution than are strategies intended to change the types of fish consumed.
KW - blood
KW - exposure
KW - fish consumption
KW - food contamination
KW - methylmercury
KW - seafoods
KW - shellfish
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043215961&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4DB54KD-1&_user=10&_handle=B-WA-A-W-WZ-MsSAYZW-UUA-AAUDDCEYUA-AAUCBVUZUA-YVVYUEAVU-WZ-U&_fmt=summary&_coverDate=12%2F01%2F2004&_rdoc=7&_orig=browse&_srch=%23toc%236999%232004%23999599996%23528770!&_cdi=6999&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e93ba417ca82e5dc9b329516dab3918
UR - email: cdc@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of Southeastern Connecticut.
AU - Dolan, M. C.
AU - Maupin, G. O.
AU - Schneider, B. S.
AU - Denatale, C.
AU - Hamon, N.
AU - Cole, C.
AU - Zeidner, N. S.
AU - Stafford, K. C., III
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 2004///
VL - 41
IS - 6
SP - 1043
EP - 1054
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-2585
AD - Dolan, M. C.: Division of Vector-Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053012121. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 120068-37-3. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - A three-year community-based study was conducted on residential properties on Mason's Island, Mystic, Connecticut, USA to determine the efficacy of a rodent-targeted acaricide (fipronil) to control immature Ixodes scapularis on Peromyscus leucopus. Results indicated that modified commercial bait boxes were effective as an acaricide delivery method for reducing nymphal and larval tick infestations on white-footed mice by 68 and 84%, respectively. Passive application of fipronil significantly reduced the infection rate of Borrelia burgdorferi among white-footed mice by 53%. Moreover, the abundance of questing I. scapularis adults on treated properties was reduced by 77% and fewer were infected with spirochetes (31%) compared with untreated sites (47%) after three years of treatment. Likewise, the abundance of host-seeking nymphs was significantly reduced on treated properties by >50%. Finally, infection rates in flagged nymphal ticks for both B. burgdorferi and Anaplasma phagocytophilum were reduced by 67 and 64%, respectively, after only two years of treatment. Results from this three-year trial indicate that the use of fipronil passively applied to reservoir animals by bait boxes is an environmentally acceptable means to control ticks, interrupt the natural disease transmission cycle, and reduce the risk of Lyme disease for residents of treated properties.
KW - acaricides
KW - bacterial diseases
KW - disease vectors
KW - fipronil
KW - human diseases
KW - insect control
KW - larvae
KW - Lyme disease
KW - nymphs
KW - reservoir hosts
KW - tickborne diseases
KW - Connecticut
KW - USA
KW - Anaplasma
KW - Anaplasma phagocytophilum
KW - Borrelia burgdorferi
KW - Ixodes scapularis
KW - man
KW - Metastigmata
KW - Peromyscus leucopus
KW - rodents
KW - Spirochaetaceae
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Peromyscus
KW - Sigmodontinae
KW - Muridae
KW - rodents
KW - Anaplasma
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal reservoirs
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - lyme borreliosis
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053012121&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats.
AU - Seo KyungWon
AU - Kim KyuBong
AU - Kim YunJung
AU - Choi JuYoung
AU - Lee KyungTae
AU - Choi KwangSik
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2004///
VL - 42
IS - 1
SP - 107
EP - 114
CY - Oxford; UK
PB - Pergamon Press
SN - 0278-6915
AD - Seo KyungWon: Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyunggu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20043010392. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9029-90-7, 637-07-0, 9035-51-2, 9007-49-2, 50812-37-8, 9025-87-0.
N2 - Phthalates are widely used as a plasticizer and cause a peroxisome proliferation. Peroxisome proliferators (PPs), such as di-2-ethylhexyl phthalate (DEHP) and clofibrate (CF) are known to have a hepatocarcinogenic potential in rodents. It has been proposed that these PPs may cause hepatocellular cancer by an oxidative damage-mediated mechanism(s). The primary purpose of this study is to find whether there is a difference between the oxidative damage by hepatocarcinogenic PPs (DEHP and CF) and the oxidative damage by weak PPs [di-n-butyl phthalate (DBP) and n-butylbenzyl phthalate (BBP)]. The second purpose is to investigate if phthalates can affect the phase I/phase II enzymes, and if the effect of PPs on metabolizing enzymes correlates with peroxisome proliferation or not. After rats were treated with PPs (DEHP, DBP and BBP; 50, 200, 1000 mg/kg, CF; 100 mg/kg, p.o., for 14 days), the activities of metabolizing enzymes and peroxisomal enzymes were investigated, and the oxidative damage was measured using 8-hydroxydeoxyguanosine (8-OHdG) in the DNA and malonedialdehyde (MDA) in the livers. These four PPs significantly increased the relative liver weights, palmitoyl-CoA oxidation and activity of carnitine acetyltransferase. DEHP was found to be the most potent PP among three phthalates. A dramatic and dose-dependent increase in hepatic MDA levels was observed in CF (100 mg/kg), DEHP (≥50 mg/kg), DBP and BBP (≥200 mg/kg) groups. However, the 8-OHdG in hepatic DNA was increased only in DEHP (1000 mg/kg) and CF groups. Activities of cytochrome P4501A1, 1A2, 3A4, UDP-glucuronosyl transferase and glutathione S-transferase were decreased overall by PPs, but there is no correlation between the inhibitory effect on metabolizing enzymes and the peroxisome proliferation. These results indicate that 8-OHdG positively correlates with carcinogenic potential of PPs, but other factors as well as peroxisomal H2O2 could be involved in the generation of 8-OHdG and the carcinogenesis of PPs. The present findings also demonstrate that the effect of PPs on xenobiotic metabolizing enzymes may be independent of the peroxisome proliferation and the oxidative stress. Thus it is possible that the PPs affect the hepatic toxification/detoxification capacity even in humans.
KW - animal models
KW - carcinogenesis
KW - carcinogens
KW - carnitine acetyltransferase
KW - clofibrate
KW - cytochrome P-450
KW - DNA
KW - enzyme activity
KW - enzymes
KW - glutathione transferase
KW - human diseases
KW - laboratory animals
KW - liver
KW - neoplasms
KW - oxidation
KW - palmitoyl-CoA hydrolase
KW - peroxisomes
KW - phthalates
KW - physiopathology
KW - plasticizers
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - deoxyribonucleic acid
KW - ligandin
KW - pathophysiology
KW - phthalic acid esters
KW - UDP-glucuronosyltransferase
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043010392&site=ehost-live&scope=site
UR - email: kwseo@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Eight-year survey of human rotavirus strains demonstrates circulation of unusual G and P types in Hungary.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Glass, R. I.
AU - Úy, M.
AU - Mihály, I.
AU - Szücs, G.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 1
SP - 393
EP - 397
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20053099043. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Between 1992 and 2000, a total of 4,173 rotavirus-positive samples were collected from two areas of Hungary. Of these, 2,020 specimens (48.4%) were analysed for G serotype, using monoclonal antibody-based immunoassay and reverse transcription-PCR. By the two methods, 1,789 samples were specified as G1 (62%), G2 (12.2%), G3 (1.4%), G4 (6.4%), G6 (1.0%), G9 (2.9%), or mixed infection (2.6%), and the remaining 231 (11.4%) could not be G typed. The linkage between G and P type, subgroup specificity, and RNA profile was investigated with a sample subset. Among these specimens, we identified both the four globally common strains (P[8],G1 subgroup II (sgII); P[4],G2 sgI; P[8],G3 sgII; and P[8],G4 sgII) and six uncommon strains (P[6],G4 sgII; P[9],G3 sgI; P[9],G6 sgI; P[14],G6 sgI; P[8],G9 sgII; and P[8],G9 sgI). All strains with P[8], P[6], P[9], and P[14] specificities had a long electropherotype, whereas most of those carrying a P[4] specificity were associated with a short electropherotype. Although once considered to be rare, P[9],G6 and P[8],G9 rotavirus strains represent potentially important new serotypes in Hungary.
KW - disease surveys
KW - genotypes
KW - human diseases
KW - molecular epidemiology
KW - polymerase chain reaction
KW - serotypes
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - disease surveillance
KW - PCR
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053099043&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/1/393
UR - email: gszucs@main.antszbar.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A pilot study of reference vibrotactile perception thresholds on the fingertip obtained with Malaysian healthy people using ISO 13091-1 equipment.
AU - Roshada Daud
AU - Maeda, S.
AU - Mustafa Kameel, N. N.
AU - Muhamad Yunus Ripin
AU - Norazman Bakrun
AU - Raemy Md Zein
AU - Kido, M.
AU - Higuchi, K.
T3 - Occupational health research in Asia: recent advances
JO - Industrial Health
JF - Industrial Health
Y1 - 2004///
VL - 42
IS - 2
SP - 189
EP - 195
CY - Kawasaki; Japan
PB - National Institute of Industrial Health
SN - 0019-8366
AD - Roshada Daud: Ergonomics Division, National Institute for Occupational Safety and Health, Lot 1, Jalan 15/1, Section 15, 43650 Bandar Baru Bangl, Selangor Darul Ehsan, Malaysia.
N1 - Accession Number: 20043107409. Publication Type: Journal Article. Note: Occupational health research in Asia: recent advances Language: English. Number of References: 29 ref. Subject Subsets: Tropical Diseases
N2 - The purpose of this study was to clarify the reference vibrotactile perception thresholds (VPT) for healthy people in Malaysia. The measurement equipment standard, ISO 13091-1, of the vibrotactile perception thresholds for the assessment of nerve dysfunction, and the analysis and interpretation of measurements at the fingertips standard, ISO 13091-2, were published in ISO/TC108/SC4/WG8 on 2001 and 2003 individually. In the ISO 13091-2 standard, the reference VPT data were obtained from few research papers. Malaysian people's VPT data are not included in this standard. In Malaysia, when the VPT is used to diagnose hand-arm vibration syndrome, the reference VPT data should be compared with those of the workers. But Malaysia does not have the reference VPT data yet. So, in this paper, the VPT was measured by using ISO 13091-1 standard equipment to obtain the reference data for Malaysian people. And these data were compared with the ISO reference data on the ISO 13091-2 standard. From the comparison of these data, it was clear that the Malaysian healthy people's VPT data were consistent with the reference data of the ISO 13091-2 standard.
KW - diagnosis
KW - ergonomics
KW - fingers
KW - human diseases
KW - nervous system diseases
KW - occupational disorders
KW - peripheral nerves
KW - reference standards
KW - standards
KW - vibration
KW - workers
KW - Malaysia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - ASEAN Countries
KW - Commonwealth of Nations
KW - Developing Countries
KW - South East Asia
KW - Asia
KW - Threshold Countries
KW - human engineering
KW - nerves
KW - neuropathy
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043107409&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a protein biomarker unique to the pandemic O3:K6 clone of Vibrio parahaemolyticus.
AU - Williams, T. L.
AU - Musser, S. M.
AU - Nordstrom, J. L.
AU - DePaola, A.
AU - Monday, S. R.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 4
SP - 1657
EP - 1665
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Williams, T. L.: Center for Food Safety and Applied Nutrition, Instrumentation and Biophysics Branch, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MA 20740-3835, USA.
N1 - Accession Number: 20053099456. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - The present method of characterizing Vibrio parahaemolyticus strains involves serotyping or detection methods based on assessment of the presence or absence of genes thought to be markers of an organism's pathogenicity. It is unclear whether these assays detect all pathogenic V. parahaemolyticus strains since a clear correlation between the presence of a particular gene and the organism's pathogenicity has not yet been observed. We have described a proteomics-based method to distinguish individual V. parahaemolyticus strains on the basis of their protein profiles and identified a specific protein that is characteristic of the pandemic O3:K6 strain and its clonal derivatives. In the pandemic clone of V. parahaemolyticus, a histone-like DNA-binding protein, HU-α, has a C-terminal amino acid sequence different from those of other strains of V. parahaemolyticus. Upon further study, it was discovered that the gene encoding this protein has a 16-kbp insert at the 3′ terminus of the open reading frame for this protein. By using the protein sequence of the unique biomarker for the pandemic clone of V. parahaemolyticus, it was possible to rationally design specific PCR-based probes and assays that permit the rapid and precise identification of pandemic strains of V. parahaemolyticus.
KW - amino acid sequences
KW - bacterial diseases
KW - biochemical markers
KW - DNA binding proteins
KW - human diseases
KW - methodology
KW - molecular biology
KW - molecular genetics
KW - open reading frames
KW - techniques
KW - Vibrio parahaemolyticus
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - biochemical genetics
KW - biomarkers
KW - methods
KW - ORFs
KW - protein sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053099456&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/4/1657
UR - email: smusser@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous analysis of multiple staphylococcal enterotoxin genes by an oligonucleotide microarray assay.
AU - Sergeev, N.
AU - Volokhov, D.
AU - Chizhikov, V.
AU - Rasooly, A.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 5
SP - 2134
EP - 2143
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Sergeev, N.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20053099702. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health
N2 - Staphylococcal enterotoxins (SEs) are a family of 17 major serological types of heat-stable enterotoxins that are one of the leading causes of gastroenteritis resulting from consumption of contaminated food. SEs are considered potential bioweapons. Many Staphylococcus aureus isolates contain multiple SEs. Because of the large number of SEs, serological typing and PCR typing are laborious and time-consuming. Furthermore, serological typing may not always be practical because of antigenic similarities among enterotoxins. We report on a microarray-based one-tube assay for the simultaneous detection and identification (genetic typing) of multiple enterotoxin (ent) genes. The proposed typing method is based on PCR amplification of the target region of the ent genes with degenerate primers, followed by characterization of the PCR products by microchip hybridization with oligonucleotide probes specific for each ent gene. We verified the performance of this method by using several other techniques, including PCR amplification with gene-specific primers, followed by gel electrophoresis or microarray hybridization, and sequencing of the enterotoxin genes. The assay was evaluated by analysis of previously characterized staphylococcal isolates containing 16 ent genes. The microarray assay revealed that some of these isolates contained additional previously undetected ent genes. The use of degenerate primers allows the simultaneous amplification and identification of as many as nine different ent genes in one S. aureus strain. The results of this study demonstrate the usefulness of the oligonucleotide microarray assay for the analysis of multitoxigenic strains, which are common among S. aureus strains, and for the analysis of microbial pathogens in general.
KW - amplification
KW - assays
KW - bacterial diseases
KW - enterotoxins
KW - genes
KW - polymerase chain reaction
KW - strains
KW - Staphylococcus aureus
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053099702&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/5/2134
UR - email: rasoolya@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance study (2000 to 2001) of G- and P-type human rotaviruses circulating in South Korea.
AU - Min BokSoon
AU - Noh YoonJu
AU - Shin JinHo
AU - Baek SunYoung
AU - Kim JaeOk
AU - Min KyungIl
AU - Ryu SeungRel
AU - Kim ByougGuk
AU - Kim DoKeun
AU - Lee SeokHo
AU - Min HongKi
AU - Ahn ByungYoon
AU - Park SueNie
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 9
SP - 4297
EP - 4299
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Min BokSoon: Division of Viral Products, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyeong-gu, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20053102943. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Tropical Diseases
N2 - Human rotavirus VP4 and VP7 gene sequences were amplified by reverse transcription-PCR from 53% (322 of 607) of fecal specimens collected from children with severe diarrhea who visited hospitals in six urban areas of South Korea in 2000 and 2001. G2 was the most frequently found G type (constituted 50.6%), followed by G1 (30.1%) and G4 (13.0%). Although the P types of high incidence were P[4] (53.1%) and P[8] (21.4%), a significant incidence of P[6] (20.2%) was also noticeable. The commonest G- and P-type combination found in this study was G2P[4], rather than G1P[8], the most prevalent type known worldwide.
KW - children
KW - diarrhoea
KW - genotypes
KW - human diseases
KW - human faeces
KW - molecular epidemiology
KW - nucleotide sequences
KW - surveillance
KW - urban areas
KW - viral diseases
KW - Korea Republic
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - diarrhea
KW - DNA sequences
KW - human feces
KW - scouring
KW - South Korea
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053102943&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/9/4297
UR - email: suenie@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sequencing and phylogenetic analysis of human genotype P[6] rotavirus strains detected in Hungary provides evidence for genetic heterogeneity within the P[6] VP4 gene.
AU - Bányai, K.
AU - Martella, V.
AU - Jakab, F.
AU - Melegh, B.
AU - Szücs, G.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 9
SP - 4338
EP - 4343
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20053102948. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Pig Science; Public Health
N2 - Although rotavirus genotype P[6] is one of the three most common VP4 specificities associated with human infection, the relatively few sequence data available in public databases suggest that the genetic variability within P[6] might be presently unexplored. Thus far, two human P[6] lineages (M37-like and AU19-like) and a single porcine P[6] lineage (Gottfried-like) have been identified by phylogenetic analysis. Serologic studies demonstrated that these three lineages are antigenically distinct from each other, a finding based on which they were classified into three subtypes, P2A[6] (M37-like), P2B[6] (Gottfried-like), and P2C[6] (AU19-like). To study heterogeneity within this genotype, we selected for molecular characterization a total of six P[6] strains detected during an ongoing surveillance in Hungary. The variable region of the VP4 gene was subjected to sequencing and phylogenetic analysis. Our data indicated that these six strains fell into two phylogenetic lineages distinguishable from the human lineages M37-like and AU19-like and from the porcine lineage Gottfried-like. Further studies are needed to understand whether these two novel lineages are genuine human strains or might have originated from animal strains and to evaluate the antigenic relationship of the novel Hungarian P[6] strains to the three established subtypes.
KW - genes
KW - genetic variation
KW - genotypes
KW - heterogeneity
KW - nucleotide sequences
KW - phylogeny
KW - strains
KW - Hungary
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053102948&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/9/4338
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro human skin penetration of diethanolamine.
AU - Kraeling, M. E. K.
AU - Yourick, J. J.
AU - Bronaugh, R. L.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2004///
VL - 42
IS - 10
SP - 1553
EP - 1561
CY - Amsterdam; Netherlands
PB - Elsevier Ltd
SN - 0278-6915
AD - Kraeling, M. E. K.: Office of Cosmetics and Colors, US Food and Drug Administration, BRF HFS-128, 8301 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 20043150976. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Public Health
N2 - Concerns about the safety of diethanolamine (DEA) have been raised by the National Toxicology Program (NTP). Therefore, we measured the extent of DEA absorption in human skin relevant to exposures from shampoos, hair dyes and body lotions. Radiolabeled [14C]-DEA was added to two commercial products from each class and applied to excised viable and non-viable human skin in flow-through diffusion cells. The products remained on the skin for 5, 30 and 24 h for shampoos, hair dyes and body lotions, respectively. After 24 h, most of the absorbed dose was found in skin: 2.8% for shampoos, 2.9% for hair dyes and 10.0% for body lotions. Only small amounts were absorbed into the receptor fluid: 0.08%, 0.09% and 0.9% for shampoos, hair dyes and body lotions respectively. There was no significant difference in the absorption of DEA through viable and non-viable skin or from product application doses of 1, 2 or 3 mg lotion/cm2. In 72 h daily repeat dose studies with a lotion, DEA appeared to accumulate in the skin (29.2%) with little diffusing out into the receptor fluid. Therefore, skin levels of DEA should not be included in estimates of systemic absorption used in exposure assessments.
KW - chemical composition
KW - cosmetics
KW - skin
KW - toxic substances
KW - toxicology
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dermis
KW - diethanolamine
KW - poisons
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043150976&site=ehost-live&scope=site
UR - email: margaret.kraeling@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Noninfectious recombinant antigen for detection of St. Louis encephalitis virus-specific antibodies in serum by enzyme-linked immunosorbent assay.
AU - Purdy, D. E.
AU - Noga, A. J.
AU - Chang, G. J. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 10
SP - 4709
EP - 4717
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Purdy, D. E.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053106502. Publication Type: Journal Article. Language: English. Number of References: 1 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Proper surveillance of virus activity and a timely response to viral outbreaks depend upon the rapid diagnosis of viral infections. The immunoglobulin M (IgM) antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) is a fast, sensitive test routinely used for the diagnosis of the medically important West Nile and St. Louis encephalitis flaviviruses. However, the suckling mouse brain-derived (SMB) antigen used in this assay is tedious to prepare and has a risk of exposing personnel to live virus and hazardous chemicals. We report the development of a St. Louis encephalitis virus (SLEV) noninfectious recombinant antigen that is a safe and easily produced alternative antigen for use in diagnostic assays. The expression plasmid pCB8SJ2, containing the premembrane and envelope structural protein-encoding regions of SLEV, was constructed to express secreted extracellular virus-like particles (VLPs) from CHO cells. Blind-coded human serum panels were assembled from patients having recent SLEV, West Nile virus (WNV), Powassan virus, or La Crosse encephalitis virus infections to assess the sensitivity and specificity of assays with SLEV VLP or SMB antigen. MAC-ELISAs with either antigen had comparable sensitivity for the detection of IgM antibodies against SLEV. Importantly, when these two antigens were tested against a human serum panel from patients having recent WNV or Powassan virus infections, the SLEV VLPs were less likely than SMB antigen to detect flavivirus cross-reactive IgM antibodies. An optimized IgG antibody capture ELISA (GAC-ELISA) with both WNV and SLEV VLPs was developed to circumvent the frequently observed higher background in the antigen-capture IgG-ELISA (ACG-ELISA). For the detection of IgG antibodies against WNV, the GAC-ELISA resulted in a statistically significant higher performance accuracy (P=0.003) than the ACG-ELISA when the WNV VLP antigen was used in both assays. However, no statistical difference was observed in the assay performance of the GAC-ELISA with SLEV VLP or the ACG-ELISA with SLEV SMB antigen.
KW - antibody testing
KW - ELISA
KW - human diseases
KW - IgG
KW - IgM
KW - immunodiagnosis
KW - recombinant antigens
KW - St Louis encephalitis
KW - West Nile fever
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antibody detection
KW - antibody tests
KW - enzyme linked immunosorbent assay
KW - serological diagnosis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053106502&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/10/4709
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mapping of genomic segments of influenza B virus strains by an oligonucleotide microarray method.
AU - Ivshina, A. V.
AU - Vodeiko, G. M.
AU - Kuznetsov, V. A.
AU - Volokhov, D.
AU - Taffs, R.
AU - Chizhikov, V. I.
AU - Levandowski, R. A.
AU - Chumakov, K. M.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2004///
VL - 42
IS - 12
SP - 5793
EP - 5801
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Ivshina, A. V.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM-470, Rockville, MD 20852, USA.
N1 - Accession Number: 20053100379. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Similar to other segmented RNA viruses, influenza viruses can exchange genome segments and form a wide variety of reassortant strains upon coreplication within a host cell. Therefore, the mapping of genome segments of influenza viruses is essential for understanding their phenotypes. In this work, we have developed an oligonucleotide microarray hybridization method for simultaneous genotyping of all genomic segments of two highly homologous strains of influenza B virus. A few strain-specific oligonucleotide probes matching each of the eight segments of the viral genomes of the B/Beijing/184/93 and B/Shangdong/7/97 strains were hybridized with PCR-amplified fluorescently labeled single-stranded DNA. Even though there were a few mismatches among the genomes of the studied virus strains, microarray hybridization showed highly significant and reproducible discrimination ability and allowed us to determine the origins of individual genomic segments in a series of reassortant strains prepared as vaccine candidates. Additionally, we were able to detect the presence of at least 5% of mixed genotypes in virus stocks even when conventional sequencing methods failed, for example, for the NS segment. Thus, the proposed microarray method can be used for (i) rapid and reliable genome mapping of highly homologous influenza B viruses and (ii) extensive monitoring of influenza B virus reassortants and the mixed genotypes. The array can be expanded by adding new oligoprobes and using more quantitative assays to determine the origin of individual genomic segments in series of reassortant strains prepared as vaccine candidates or in mixed virus populations.
KW - analytical methods
KW - gene mapping
KW - genomes
KW - nucleotide sequences
KW - strains
KW - Influenza B virus
KW - influenzavirus B
KW - Influenzavirus B
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - analytical techniques
KW - DNA sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053100379&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/42/12/5793
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure assessment and analysis for biological agents.
AU - Martinez, K. F.
AU - Rao, C. Y.
AU - Burton, N. C.
JO - Grana
JF - Grana
Y1 - 2004///
VL - 43
IS - 4
SP - 193
EP - 208
CY - Oslo; Norway
PB - Taylor & Francis AS
SN - 0017-3134
AD - Martinez, K. F.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R11, Cincinnati, OH 45213, USA.
N1 - Accession Number: 20043217686. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 57-87-4. Subject Subsets: Medical & Veterinary Mycology
N2 - Airborne biological agents have become prominent safety and health issues in agriculture, biotechnology, industrial settings, and the indoor environment. Each of these environments presents unique exposure concerns due to the nature of the encountered biological agent, the microbial concentrations, the modes of exposure, and the susceptibility of the exposed population. Acceptable levels of airborne microorganisms have not been established and the sampling methods and analytical techniques employed to assess airborne biocontaminants are varied and non-standardized. This paper reviews and compares the different air sampling methods for biological agents and classical analytical methods (i.e., culture and microscopy), analysis for specific microorganism constituents (i.e., ergosterol, muramic acid, glucans, allergens, mycotoxins, endotoxins) and molecular methods (i.e., polymerase chain reaction). Each of the described methods has distinct advantages and disadvantages. Selection of sampling and analytical methods depends upon the nature of the information that is sought; there is no one ideal sampling or analytical method. Combinations of sampling and analytical methods can provide a wide range of data that can be effectively tailored to many different environmental settings.
KW - allergens
KW - analytical methods
KW - contaminants
KW - culture techniques
KW - endotoxins
KW - ergosterol
KW - exposure
KW - glucans
KW - microorganisms
KW - microscopy
KW - mycotoxins
KW - polymerase chain reaction
KW - reviews
KW - sampling
KW - susceptibility
KW - analytical techniques
KW - biocontaminants
KW - biological agents
KW - fungal toxins
KW - micro-organisms
KW - muramic acids
KW - PCR
KW - sampling techniques
KW - Human Health and the Environment (VV500)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043217686&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities.
AU - Huber, W. W.
AU - Teitel, C. H.
AU - Coles, B. F.
AU - King, R. S.
AU - Wiese, F. W.
AU - Kaderlik, K. R.
AU - Casciano, D. A.
AU - Shaddock, J. G.
AU - Mulder, G. J.
AU - Ilett, K. F.
AU - Kadlubar, F. F.
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
Y1 - 2004///
VL - 44
IS - 4
SP - 265
EP - 276
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0893-6692
AD - Huber, W. W.: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20043206688. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2, 50812-37-8. Subject Subsets: Human Nutrition
N2 - Coffee drinking has been associated with reduced incidence of colorectal cancer, possibly via chemoprotection/modification of the metabolism of dietary heterocyclic amine carcinogens such as 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) by kahweol and cafestol palmitates (K/C), two components of unfiltered coffee. Using the PhIP-exposed male Fisher F344 rat as a model, K/C have been shown to reduce colonic PhIP-DNA adducts by >50%. We have used the male F344 rat to investigate the effects of dietary K/C (0.02-0.2% as a 1:1 mixture) on the metabolism of PhIP by N-acetyltransferase-(NAT), sulfotransferase-(SULT), and glutathione-dependent pathways. K/C decreased hepatic NAT-dependent PhIP activation by up to 80% in a dose-dependent manner. Conversely, hepatic glutathione S-transferase (GST) activity/expression increased, e.g., 3-4 fold toward 1-chloro-2,4-dinitrobenzene (total activity), up to 23-fold toward 4-vinylpyridine (rGSTP1), and ~7-fold for rGSTA2 protein. These effects had fully developed after 5 days of the test diet and persisted for at least 5 days after withdrawal of K/C. Hepatic glutathione increased two- to threefold and this increase was more short-lived than other changes. K/C did not modify hepatic SULT activity or colon NAT and GST activities. Benzylisothiocyanate and black tea, which have also been shown to reduce the formation of PhIP-DNA adducts in this model, had little effect on hepatic NAT, SULT, GST, or GSH. In primary culture of rat hepatocytes, both kahweol and cafestol palmitates reduced NAT activity by 80%. In summary, the unique potential of K/C to convert rapid acetylators to a slow acetylator phenotype, accompanied by GST induction, might contribute to chemoprevention against cancers associated with heterocyclic amines.
KW - carcinogens
KW - coffee
KW - colon
KW - DNA
KW - enzyme activity
KW - enzymes
KW - glutathione transferase
KW - laboratory animals
KW - liver
KW - liver cells
KW - palmitates
KW - tea
KW - Camellia sinensis
KW - Coffea
KW - rats
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine
KW - benzylisothiocyanate
KW - black tea
KW - cafestol palmitate
KW - deoxyribonucleic acid
KW - hepatocytes
KW - kahweol palmitate
KW - ligandin
KW - N-acetyltransferase
KW - sulfotransferases
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043206688&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/109670016/ABSTRACT
UR - email: wolfgang.huber@meduniwien.ac.at
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An evaluation of portable high-efficiency particulate air filtration for expedient patient isolation in epidemic and emergency response.
AU - Mead, K.
AU - Johnson, D. L.
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
Y1 - 2004///
VL - 44
IS - 6
SP - 635
EP - 645
CY - St Louis; USA
PB - Mosby Inc.
SN - 0196-0644
AD - Mead, K.: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway (MS R5), Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043212710. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Extraordinary incidents resulting in airborne infectious disease outbreaks could produce patient isolation requirements that exceed most hospitals' capacity. This article investigates expedient methods to establish airborne infection isolation areas using a commercially available portable filtration unit and common hardware supplies. The study was conducted within a conventional, nonisolation hospital room, and researchers evaluated several airborne isolation configurations that did not require building ventilation or structural modifications. A portable high-efficiency particulate air filtration unit and full-length plastic curtains established a "zone-within-zone" protective environment using local capture and directional airflows. The cost of constructing the expedient configurations was less than US$2,300 and required fewer than 3 person-hours to construct. A medical nebulizer aerosolized polystyrene latex microspheres to generate respirable condensation nuclei. Aerosol spectrometers sized and counted respirable particles at the source patient and health care worker positions and in areas outside the inner zone. The best-performing designs showed no measurable source migration out of the inner isolation zone and mean respirable particle counts up to 87% lower at the health care worker position(s) than those observed directly near the source patient location. Investigators conclude that with careful implementation under emergency circumstances in which engineered isolation rooms are unavailable, expedient methods can provide affordable and effective patient isolation while reducing exposure risks and potential disease transmission to health care workers, other patients, and visitors.
KW - air filters
KW - epidemics
KW - epidemiology
KW - filtration
KW - human diseases
KW - infectious diseases
KW - outbreaks
KW - ventilation
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043212710&site=ehost-live&scope=site
UR - http://www2.us.elsevierhealth.com/scripts/om.dll/serve?action=searchDB&searchDBfor=art&artType=abs&id=as0196064404012107&nav=abs
UR - email: kmead@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in occupational lead exposure since the 1978 OSHA lead standard.
AU - Okun, A.
AU - Cooper, G.
AU - Bailer, A. J.
AU - Bena, J.
AU - Stayner, L.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2004///
VL - 45
IS - 6
SP - 558
EP - 572
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Okun, A.: Education and Information Division (MS C14), National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20043155630. Publication Type: Journal Article. Language: English. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - Background: The purpose of the study was to evaluate trends in occupational lead exposures throughout U.S. industry after the establishment of the general industry lead standard in 1978 and the construction industry standard in 1993. Methods: Lead exposure measurements collected by the Occupational Safety and Health Administration (OSHA) under their compliance and consultation programs were analysed. Time trends in the distributions of exposure levels were evaluated graphically. Trends in the proportion of exposures above the OSHA permissible exposure limit (PEL) were analysed using logistic regression models. Results: The distribution of lead exposure levels declined over the study time period for general industry, but not for construction. The median exposure levels for general industry facilities decreased five- to tenfold. Logistic regression models reveal statistically significant declines in the odds of a lead exposure exceeding the PEL. Conclusions: This study provides evidence for relatively large decreases in lead exposure levels in general industry facilities over time. The study does not provide similar evidence for the construction industry. Given the limited number of years of data available since the implementation of the revised construction standard for lead, re-analysis of lead exposure levels within this industry would be worthwhile when more data become available.
KW - construction workers
KW - exposure
KW - human diseases
KW - industrial wastes
KW - lead
KW - occupational health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - building workers
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043155630&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/108565869/ABSTRACT
UR - email: AHO1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization.
AU - McCanlies, E. C.
AU - Ensey, J. S.
AU - Schuler, C. R.
AU - Kreiss, K.
AU - Weston, A.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2004///
VL - 46
IS - 2
SP - 95
EP - 103
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - McCanlies, E. C.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 3014, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043184544. Publication Type: Journal Article. Language: English. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - Background: Several case-control studies have found an association between chronic beryllium disease (CBD) and HLA-DPB1 gene variants. However, the relationship between HLA-DPB1 and beryllium sensitization, and whether the presence of one or two HLA-DPB1Glu69 alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved. Methods: Restriction fragment length polymorphism (RFLP) analysis was used to address these questions in a large population-based cohort consisting of 884 beryllium workers (90 with CBD, 64 beryllium sensitized). Results: HLA-DPB1Glu69 was associated with both CBD (OR=9.4; 95% CI=5.4, 16.6) and sensitization (OR=3.3, 95% CI=1.9, 5.9). Further, workers with CBD and sensitization were more likely to be homozygous HLA-DPB1Glu69 compared to workers without disease or sensitization (P<0.001). Conclusions: Follow-up of this cohort, scrutiny of HLA-DPB1 haplotypes, and evaluation of gene-environment and gene-gene interactions will be important for fully understanding the immunogenetic nature of this occupational disease.
KW - beryllium
KW - exposure
KW - genes
KW - genetic variation
KW - human diseases
KW - metal workers
KW - occupational hazards
KW - restriction fragment length polymorphism
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - RFLP
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043184544&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/109561060/ABSTRACT
UR - email: agw8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Airflow obstruction attributable to work in industry and occupation among U.S. race/ethnic groups: a study of NHANES III data.
AU - Hnizdo, E.
AU - Sullivan, P. A.
AU - Bang, K. M.
AU - Wagner, G.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2004///
VL - 46
IS - 2
SP - 126
EP - 135
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Hnizdo, E.: Division of Respiratory Disease Studies, MS H2800, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043184536. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Objectives: To estimate the fraction of airflow obstruction attributable to workplace exposure by U.S. race/ethnic group. Methods: U.S. population-based third National Health and Nutrition Examination Survey (NHANES III) data on 4,086 Caucasians, 2,774 African-Americans, and 2,568 Mexican-Americans, aged 30-75, were studied. Airflow obstruction was defined as FEV1/FVC<75% and FEV1<80% predicted. Weighted prevalence, and prevalence odds ratios (OR) adjusted for the effect of age, smoking status, pack-years, body mass index, education, and socio-economic status were estimated using SUDAAN software. Results: Industries with the most cases of airflow obstruction attributable to workplace exposure include: armed forces; rubber, plastics, and leather manufacturing; utilities; textile mill manufacturing; health care; food products manufacturing; sales; construction; and agriculture. The fraction of cases with airflow obstruction associated with work in industry varied by race/ethnic group and was estimated as 22.2% (95% CI 9.1-33.4) among Caucasians, 23.4% (95% CI 2.2-40.0) among African-Americans, and 49.6% (32.1-62.6) among Mexican-Americans. Conclusions: This study found differences in the fraction of airflow obstruction cases associated with employment pattern among major U.S. race/ethnic population groups.
KW - blacks
KW - construction workers
KW - ethnic groups
KW - ethnicity
KW - exposure
KW - farm workers
KW - Hispanics
KW - human diseases
KW - leather workers
KW - medical auxiliaries
KW - military personnel
KW - occupational hazards
KW - plastic workers
KW - respiratory diseases
KW - rubber workers
KW - textile workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - allied health occupations
KW - building workers
KW - ethnic differences
KW - health workers
KW - lung diseases
KW - United States of America
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043184536&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/109561068/ABSTRACT
UR - email: exh6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Smoking is an occupational hazard.
AU - Howard, J.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2004///
VL - 46
IS - 2
SP - 161
EP - 169
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Howard, J.: National Institute for Occupational Safety and Health, Washington, DC 20201, USA.
N1 - Accession Number: 20043184539. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Even though the prevalence of tobacco smoking has declined in the general population and among white-collar workers, the prevalence of tobacco smoking among blue-collar workers remains unacceptably high. Blue-collar workers experience greater exposure to workplace toxins which can add to, or even multiply, their risk of adverse health effects from tobacco smoking. Among blue-collar workers, workers in the restaurant, bar, and gaming industries are exposed to much higher levels of environmental tobacco smoke (ETS) than are office workers, and are at increased risk of cancer and cardiovascular diseases even if they are non-smokers themselves. Methods: The literature on health risks, and the disparity between white and blue collar workers in smoking prevalence, and the literature on various tobacco control strategies provide the sources on which this review is based. Conclusions: Over the past 20 years, the accumulating scientific evidence about smoking as an occupational hazard has prompted the implementation of various educational, economic, and legal tobacco control strategies.
KW - cardiovascular diseases
KW - human diseases
KW - neoplasms
KW - occupational hazards
KW - tobacco smoking
KW - work places
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043184539&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/109561057/ABSTRACT
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of data limitations when modeling fatal occupational injury rates.
AU - Bena, J. F.
AU - Bailer, A. J.
AU - Loomis, D.
AU - Richardson, D.
AU - Marshall, S.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2004///
VL - 46
IS - 3
SP - 271
EP - 283
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Bena, J. F.: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20043183885. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Occupational fatal injury rate studies are often based upon uncertain and variable data. The numerator in rate calculations is often obtained from surveillance systems that can understate the true number of deaths. Worker-years, the denominator in many occupational rate calculations, are frequently estimated from sources that exhibit different amounts of variability. Methods: Effects of these data limitations on analyses of trends in occupational fatal injuries were studied using computer simulation. Fatality counts were generated assuming an undercount. Employment estimates were produced using two different strategies, reflecting either frequent but variable measurements or infrequent, precise estimates with interpolated estimates for intervening years. Poisson regression models were fit to the generated data. A range of empirically motivated fatality rate and employment parameters were studied. Results: Undercounting fatalities resulted in biased estimation of the intercept in the Poisson regression model. Relative bias in the trend estimate was near zero for most situations, but increased when a change in fatality undercounting over time was present. Biases for both the intercept and trend were larger when small employment populations were present. Denominator options resulted in similar rate and trend estimates, except where the interpolated method did not capture true trends in employment. Conclusions: Data quality issues such as consistency of conditions throughout the study period and the size of population being studied affect the size of the bias in parameter estimation.
KW - calculation
KW - computer simulation
KW - estimates
KW - human diseases
KW - occupational hazards
KW - trauma
KW - trends
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estimations
KW - traumas
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043183885&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/109593687/ABSTRACT
UR - email: jbena@bio.ri.ccf.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Activities of dicationic compounds against Trichomonas vaginalis.
AU - Crowell, A. L.
AU - Stephens, C. E.
AU - Kumar, A.
AU - Boykin, D. W.
AU - Secor, W. E.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2004///
VL - 48
IS - 9
SP - 3602
EP - 3605
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Crowell, A. L.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341, USA.
N1 - Accession Number: 20053097734. Publication Type: Journal Article. Language: English. Registry Number: 443-48-1. Subject Subsets: Protozoology
N2 - We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 µM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
KW - antiprotozoal agents
KW - antiprotozoal properties
KW - drug resistance
KW - metronidazole
KW - Trichomonas vaginalis
KW - Trichomonas
KW - Trichomonadidae
KW - Trichomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - anti-protozoal properties
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053097734&site=ehost-live&scope=site
UR - http://aac.asm.org/cgi/content/full/48/9/3602
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays.
AU - Kim InYoung
AU - Shin JaeHo
AU - Kim HyungSik
AU - Lee SuJung
AU - Kang IlHyun
AU - Kim TaeSung
AU - Moon HyunJu
AU - Choi KwangSik
AU - Moon Aree
AU - Han SoonYoung
JO - Journal of Reproduction and Development
JF - Journal of Reproduction and Development
Y1 - 2004///
VL - 50
IS - 2
SP - 245
EP - 255
CY - Tokyo; Japan
PB - Japanese Society of Animal Reproduction
SN - 0916-8818
AD - Kim InYoung: Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20043104380. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 52315-07-8, 52918-63-5, 51630-58-1, 52645-53-1, 7696-12-0. Subject Subsets: Agricultural Entomology
N2 - Pyrethroid insecticides are among the most commonly used classes of insecticides worldwide, but their endocrine disrupting activities remain unclear. Therefore, in the present study, we examined the estrogenic activities of pyrethroid insecticides in E-screen and competition binding assays. In addition, we measured oestrogen receptor (ER) protein and pS2 mRNA levels in human breast cancer cells (MCF-7 BUS) to clarify the mechanism of their estrogenicity. Seven pyrethroid insecticides (bioallethrine, cypermethrin, deltamethrin, fenvalerate, permethrin, sumithrin, and tetramethrin) were tested because of their worldwide usage. In addition, 17β-estradiol was tested as a positive control. As expected, 17β-estradiol significantly increased MCF-7 BUS cell proliferation at concentrations of 10-11 M and above. Of the pyrethroid insecticides tested, only sumithrin increased MCF-7 BUS cell proliferation in a dose-dependent manner; the maximum induction of cell proliferation was observed at a dose of 10-5 M. In the anti-estrogenic activity test, bioallethrin, fenvalerate, and permethrin significantly inhibited 17β-estradiol-induced MCF-7 BUS cell proliferation at 10-6 M, a concentration comparable to the effective dose (10-9 M) of ICI 182 780, a pure ER antagonist. However, none of the pyrethroid insecticides competitively inhibited the binding of [3H]estradiol to rat uterus ERs in competition binding assays. Both 17β-estradiol (10-10 M) and sumithrin (10-5 M) decreased the levels of cytosolic ERα and ERβ protein expression significantly as compared with the vehicle control. In addition, 17β-estradiol (10-10 M) increased pS2 mRNA expression markedly, and sumithrin significantly increased pS2 mRNA levels in a dose-dependent manner. The other six compounds tested in the present study did not affect ER protein levels or pS2 mRNA levels. These results suggest that certain pyrethroid insecticides may be considered to be estrogen-like chemicals that act through pathways other than direct ER binding, and may function as endocrine modulators in both wildlife and humans.
KW - biochemical receptors
KW - breast cancer
KW - cells
KW - cypermethrin
KW - deltamethrin
KW - fenvalerate
KW - in vitro
KW - insecticides
KW - messenger RNA
KW - neoplasms
KW - oestrogens
KW - permethrin
KW - tetramethrin
KW - bioallethrine
KW - cancers
KW - estrogens
KW - mRNA
KW - sumithrin
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043104380&site=ehost-live&scope=site
UR - email: soonyoungh@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of rotavirus infection in a Hungarian paediatric hospital: a short communication.
AU - Bányai, K.
AU - Sas, Y.
AU - Varga, L.
AU - Szucs, G.
JO - Acta Microbiologica et Immunologica Hungarica
JF - Acta Microbiologica et Immunologica Hungarica
Y1 - 2004///
VL - 51
IS - 4
SP - 431
EP - 435
CY - Budapest; Hungary
PB - Akadémiai Kiadó
SN - 1217-8950
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20053008643. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - In anticipation of a future vaccination programme against rotavirus disease, a longitudinal survey has been set up to evaluate the epidemiologic features of rotavirus infections. In this report, hospitalization data and serotyping results are compiled from an epidemiologic survey conducted in Baranya County, Hungary between July 1996 and June 2000. Rotavirus-associated hospitalization constituted a major part of infectious gastroenteritis cases (range, 14.9-28.5%). A higher proportion of rotavirus-positive cases was recorded when the serotype of predominant strains changed from G1 (1996-1999) to G4 (1999-2000), however, due to the short time period it was not possible to demonstrate a firm association between serotype prevalence and rotavirus-associated hospitalization rate. In the future, such studies might help to understand if serotype-specific immunity against rotavirus infection plays an important role at the population level, and if (re-)emerging rotavirus strains can affect the annual disease burden.
KW - children
KW - disease prevalence
KW - disease surveys
KW - epidemiology
KW - gastroenteritis
KW - human diseases
KW - serotypes
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - disease surveillance
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053008643&site=ehost-live&scope=site
UR - email: szucsgy@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developing new regulatory approaches to antimicrobial safety.
AU - Tollefson, L.
A2 - Helmuth, R.
T3 - Special issue: 1st International symposium towards a risk analysis of antibiotic resistance.
JO - Journal of Veterinary Medicine. Series B
JF - Journal of Veterinary Medicine. Series B
Y1 - 2004///
VL - 51
IS - 8/9
SP - 415
EP - 418
CY - Berlin; Germany
PB - Blackwell Publishing
SN - 0931-1793
AD - Tollefson, L.: US Food and Drug Administration, Center for Veterinary Medicine, 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20043196172. Publication Type: Journal Article; Conference paper. Note: Special issue: 1st International symposium towards a risk analysis of antibiotic resistance. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - Resistance to antimicrobial agents is of concern to public health officials worldwide. In industrialized countries, a significant source of antimicrobial-resistant food-borne infections in humans is the acquisition of resistant bacteria originating from animals. The US Food and Drug Administration (FDA) is committed to resolving the public health impact arising from the use of antimicrobial drugs in food-producing animals. The FDAs goal is to ensure that significant human antimicrobial therapies are not compromised or lost while providing for the safe use of antimicrobials in food animals. Recently the FDA published a guidance document titled 'Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to their Microbiological Effects on Bacteria of Human Health Concern' (US Food and Drug Administration, Center for Veterinary Medicine, 2003). This document outlines a pathway drug sponsors can use to address concerns about antimicrobial resistance prior to approval of their drug. The process uses a qualitative risk assessment approach to assess the potential of the intended use of a product to develop resistance in bacteria that may harm humans. The level of risk determines the level of risk management that is required for the drug to be used. The Food and Drug Administration (FDA) always has the option of not approving a drug if the risk of a public health consequence is too high.
KW - antibiotics
KW - drug resistance
KW - food safety
KW - livestock
KW - regulations
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Pesticide and Drug Resistance (HH410)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043196172&site=ehost-live&scope=site
UR - email: ltollefs@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antiinflammatory triterpenoid saponins from the seeds of Aesculus chinensis.
AU - Wei Feng
AU - Ma LinYun
AU - Jin, W. T.
AU - Ma ShuangCheng
AU - Han GuoZhu
AU - Khan, I. A.
AU - Lin RuiChao
JO - Chemical & Pharmaceutical Bulletin
JF - Chemical & Pharmaceutical Bulletin
Y1 - 2004///
VL - 52
IS - 10
SP - 1246
EP - 1248
CY - Tokyo; Japan
PB - Pharmaceutical Society of Japan
SN - 0009-2363
AD - Wei Feng: Division of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, 2 Tiantan Xili, Beijing, 100050, China.
N1 - Accession Number: 20043203217. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science; Forest Products; Forestry; Seed Science
N2 - The phytochemical study of the ethanol extract of the seeds of A. chinensis collected from Luoyang, Henan, China, resulted in the isolation of a new triterpenoid saponin, together with 5 known triterpenoid saponins (desacylescin 1, escin Ia, isoescin Ia, escin Ib and isoescin Ib). The structure of the new compound was elucidated based on spectral data to be 21,28-di-O-acetylprotoaescigenin-3-O-[β-D-glucopyranos yl(1-2)][β-D-glucopyranosyl(1-4)]-β-D-glucopyranosiduronic acid (aesculiside A). The antiinflammatory activities of escin Ia, isoescin Ia, escin Ib and isoescin Ib were compared with those of total saponin extracts, and single saponins showed more potent activity than total saponin extracts in mice.
KW - antiinflammatory properties
KW - chemical composition
KW - chemical structure
KW - in vitro
KW - medicinal plants
KW - non-wood forest products
KW - pharmacology
KW - plant composition
KW - plant extracts
KW - seeds
KW - triterpenoid saponins
KW - China
KW - Henan
KW - Aesculus
KW - mice
KW - Hippocastanaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Aesculus
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Central Southern China
KW - China
KW - Aesculus chinensis
KW - anti-inflammatory properties
KW - chemical constituents of plants
KW - drug plants
KW - Honan
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - People's Republic of China
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Non-wood Forest Products (KK540)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043203217&site=ehost-live&scope=site
UR - email: hograwei@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Autoclave sterilization produces acrylamide in rodent diets: implications for toxicity testing.
AU - Twaddle, N. C.
AU - Churchwell, M. I.
AU - McDaniel, L. P.
AU - Doerge, D. R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2004///
VL - 52
IS - 13
SP - 4344
EP - 4349
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Twaddle, N. C.: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063032636. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Acrylamide (AA) is a neurotoxic and carcinogenic contaminant that is formed during the cooking of starchy foods. Assessment of human risks from toxicants is routinely performed using laboratory rodents, and such testing requires careful control of unintended exposures, particularly through the diet. This study describes an analytical method based on liquid chromatography with electrospray tandem mass spectrometry that was used to measure endogenous AA in rodent diets and to survey a number of commercial products for contamination. Method sensitivity permitted accurate quantification of endogenous levels of AA in raw diets below 20 ppb. Autoclaving a standard rodent diet (NIH-31) increased the AA content 14-fold, from 17 to 240 ppb. A nutritionally equivalent diet that was sterilized by irradiation was found to contain ~10 ppb of AA (NIH-31IR). A toxicokinetic study of AA and its epoxide metabolite, glycidamide, was performed by switching mice from NIH-31IR to the autoclaved diet for a 30 min feeding period (average AA dose administered was 4.5 µg/kg of body weight). The concentrations of AA and glycidamide were measured in serum collected at various times. The elimination half-lives and the areas under the respective concentration-time curves were similar for AA and glycidamide. Mice maintained on autoclaved NIH-31 diet, but otherwise untreated, showed elevated steady state levels of a glycidamide-derived DNA adduct in liver relative to mice maintained on the irradiated diet. This study demonstrates that a heat sterilization procedure used in laboratory animal husbandry (i.e., autoclaving) can lead to the formation of significant levels of AA in basal diets used for toxicity testing. AA in rodent diets is bioavailable, is distributed to tissues, and is metabolically activated to a genotoxic metabolite, which produces quantifiable cumulative DNA damage. Although the contribution of endogenous AA to the incidence of tumors in multiple organs of rodents otherwise untreated in chronic carcinogenicity bioassays (i.e., control groups) is not known, the reduction of endogenous AA through the use of a suitable irradiated diet was deemed to be critical for ongoing studies of AA carcinogenicity and neurotoxicity.
KW - acrylamides
KW - analytical methods
KW - animal models
KW - diet
KW - food contamination
KW - laboratory animals
KW - liquid chromatography
KW - mass spectrometry
KW - sterilization
KW - techniques
KW - toxicology
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063032636&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i13/abs/jf0497657.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage.
AU - Ang, C. Y. W.
AU - Hu, L. H.
AU - Heinze, T. M.
AU - Cui, Y. Y.
AU - Freeman, J. P.
AU - Kozak, K.
AU - Luo, W. H.
AU - Liu, F. F.
AU - Mattia, A.
AU - DiNovi, M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2004///
VL - 52
IS - 20
SP - 6156
EP - 6164
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Ang, C. Y. W.: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063034331. Publication Type: Journal Article. Language: English. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Postharvest Research
N2 - Several bioactive botanicals including St. John's wort (SJW; Hypericum perforatum L.) have been used to formulate functional foods and beverages. This study aimed to investigate the stability of SJW components in aqueous solutions and fruit-flavored drinks. Changes of active marker components (hypericin, pseudohypericin, hyperforin, and adhyperforin) as affected by pH and light exposure were determined by HPLC, and the degradation of hyperforin was analysed by LC-MS/MS and NMR. SJW components were found to be unstable in acidic aqueous solutions. More changes occurred under light exposure, with hyperforin and adhyperforin decreasing the most. Less severe changes were observed in the drink sample as compared to the pH 2.65 solution. Major degradation products of hyperforin in acidic aqueous solutions were identified as furohyperforin, furohyperforin hydroperoxide, and furohyperforin isomer a. The latter was also found in the drink product containing SJW as an ingredient. Biological activities and potential quality and safety implications of these chemical changes are yet to be evaluated.
KW - chemical composition
KW - food safety
KW - medicinal plants
KW - Hypericum perforatum
KW - Hypericum
KW - Clusiaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - adhyperforin
KW - drug plants
KW - hyperforin
KW - hypericin
KW - medicinal herbs
KW - officinal plants
KW - pseudohypericin
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063034331&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i20/abs/jf0490596.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).
AU - Roberts, D. W.
AU - Doerge, D. R.
AU - Churchwell, M. I.
AU - Costa, G. G. da
AU - Marques, M. M.
AU - Tolleson, W. H.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2004///
VL - 52
IS - 21
SP - 6623
EP - 6632
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Roberts, D. W.: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063034658. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2, 486-66-8, 485-72-3, 446-72-0. Subject Subsets: Human Nutrition
N2 - Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783-4790), it was demonstrated that human liver microsomes converted biochanin A and formononetin to genistein and daidzein. This paper now shows CYP1B1-catalyzed O-demethylation of biochanin A and formononetin to produce genistein and daidzein, respectively, which inhibit CYP1B1. Recombinant human CYP1A1 or CYP1B1 was incubated with biochanin A or formononetin. CYP1A1 catalyzed isoflavone 4′-O-demethylation and hydroxylations with similar efficiency, whereas CYP1B1 favored 4′-O-demethylation over hydroxylations. Three of the biochanin A metabolites (5,7,3′-trihydroxy-4′-methoxyisoflavone, 5,7,8-trihydroxy-4′-methoxyisoflavone, and 5,6,7-trihydroxy-4′-methoxyisoflavone) were characterized by 1H NMR spectroscopy and mass spectrometry. Daidzein (Ki=3.7 µM) exhibited competitive inhibition of CYP1B1 7-ethoxyresorufin O-deethylase activity, and genistein (Ki=1.9 µM) exhibited mixed inhibition. Biochanin A and/or formononetin may exert anticarcinogenic effects directly by acting as competitive substrates for CYP1B1 or indirectly through their metabolites daidzein and genistein, which inhibit CYP1B1.
KW - cytochrome P-450
KW - daidzein
KW - formononetin
KW - genistein
KW - isoflavones
KW - metabolism
KW - man
KW - Trifolium pratense
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Trifolium
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - biochanin A
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063034658&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i21/abs/jf049418x.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of multiclass methods for drug residues in eggs: silica SPE cleanup and LC-MS/MS analysis of ionophore and macrolide residues.
AU - Heller, D. N.
AU - Nochetto, C. B.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2004///
VL - 52
IS - 23
SP - 6848
EP - 6856
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Heller, D. N.: Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20063034789. Publication Type: Journal Article. Language: English. Registry Number: 114-07-8, 11054-70-9, 17090-79-8, 55134-13-9, 303-81-1, 1401-69-0, 53003-10-4. Subject Subsets: Human Nutrition
N2 - A method was developed that is suitable for screening eggs for a variety of nonpolar residues in a single procedure. Residues are extracted by silica solid-phase extraction (SPE). Analysis is conducted via reverse-phase gradient liquid chromatography, electrospray ionization, and tandem ion trap mass spectrometry. For screening purposes (based on a single precursor-product ion transition) the method can detect ionophore (lasalocid, monensin, salinomycin, narasin) and macrolide (erythromycin, tylosin) residues in egg at ~1 ng/mL (ppb) and above and novobiocin residues at ~3 ppb and above. Conditions are described for confirmatory analysis based on multiple ions in the product ion spectrum. The extraction efficiency for ionophores was estimated at 60-85%, depending on drug. Recovery of macrolides and novobiocin was not as good (estimated at 40-55% after a hexane wash of the final extract was included), but the method consistently screened and confirmed these residues at concentrations below the target of 10 ppb. The method was applied to eggs from hens dosed with each drug individually. Lasalocid was found to have the highest probability of detection in eggs based on its high ionization efficiency and higher rate of deposition relative to the other drugs. The method is part of a larger scheme to provide surveillance methods for a wide variety of drug residues in eggs.
KW - detection
KW - drug residues
KW - eggs
KW - erythromycin
KW - ionophores
KW - lasalocid
KW - liquid chromatography
KW - macrolide antibiotics
KW - mass spectrometry
KW - methodology
KW - monensin
KW - narasin
KW - novobiocin
KW - salinomycin
KW - tylosin
KW - methods
KW - rumensin
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063034789&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i23/abs/jf040185j.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of cigarette use among 14 racial/ethnic populations - United States, 1999-2001.
AU - Carmona, R.
AU - Gfroerer, J.
AU - Caraballo, R.
AU - Yee, S. L.
AU - Husten, C.
AU - Pechacek, T.
AU - Robinson, R. G.
AU - Lee, C.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2004///
VL - 53
IS - 3
SP - 49
EP - 52
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Carmona, R.: Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043033837. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report summarizes the results of the analysis of self-reported data on cigarette smoking among persons from the USA aged ≥12 years collected during 1999-2001 from the National Survey on Drug Use and Health. Data were collected from 14 ethnic populations: Whites, Blacks, American Indian/Alaska Native (AI/AN), Hawaiian/other Pacific Islander, Chinese, Filipino, Japanese, Asian Indian, Korean, Vietnamese, Mexican, Puerto Rican, Central or South American, and Cuban. Results indicate that the prevalence of cigarette smoking among adults ≥18 years ranged from 40.4% for AI/ANs to 12.3% for the Chinese population and the prevalence among youths aged 12-17 years ranged from 27.9% for AI/ANs to 5.2% for the Japanese population.
KW - adolescents
KW - adults
KW - age
KW - American indians
KW - Asians
KW - blacks
KW - children
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - Inuit
KW - Mexican-Americans
KW - tobacco smoking
KW - whites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Eskimos
KW - ethnic differences
KW - teenagers
KW - United States of America
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043033837&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Laboratory testing policies and their effects on routine surveillance of community antimicrobial resistance.
AU - Heginbothom, M. L.
AU - Magee, J. T.
AU - Bell, J. L.
AU - Dunstan, F. D. J.
AU - Howard, A. J.
AU - Hillier, S. L.
AU - Palmer, S. R.
AU - Mason, B. W.
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2004///
VL - 53
IS - 6
SP - 1010
EP - 1017
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Heginbothom, M. L.: National Public Health Service for Wales, Abton House, Wedal Road, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20043123535. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Objective: To investigate the effects of laboratory testing policies, particularly selective testing, rule-based reporting and isolate identification, on estimates of community antimicrobial resistance. Materials and methods: Antibiotic resistance estimates were analysed from an all-Wales dataset for approximately 300 000 community isolates of common pathogens. Results: Selective testing policies were often associated with markedly increased resistance, particularly for second-line testing. Site-specific testing tended to yield variant resistance estimates for eye and ear isolates. Estimates from rule-based reporting deviated markedly from test-result-based reporting. Urinary isolates reported as Escherichia coli showed greater susceptibility than those reported as undifferentiated urinary 'coliforms'. The proportion of isolates tested for an antibiotic by a laboratory was a useful indicator of selective testing in this dataset. Selective testing policies had invariably been applied where the proportion of isolates of a species tested against an antibiotic was <90%. As this proportion fell with increasingly selective policies, divergence from pooled-all-Wales non-selective estimates tended to increase, with a bias to increased resistance. Conclusions: Selective testing, rule-based reporting and urinary coliform identification policies all had significant effects upon resistance estimates. Triage based upon the proportion of isolates tested seemed a useful tool in assigning analysis resources. Where <20% of isolates were tested, selective policies with inherent bias to increased resistance were common, the low number of isolates gave high potential sampling errors, and little confidence could be placed in the resistance estimate. Where 20-90% of isolates were tested, detailed analysis sometimes revealed resistance estimates that might be usefully retrieved. Where ≥90% of isolates were tested, there was no evidence of selective testing, and inter-laboratory variation in estimates appeared to be safely ascribable to other effects, e.g. methodology or real variation in resistance levels.
KW - antibiotics
KW - drug resistance
KW - laboratory tests
KW - policy
KW - UK
KW - Wales
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - E. coli
KW - United Kingdom
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043123535&site=ehost-live&scope=site
UR - http://jac.oupjournals.org/cgi/content/abstract/53/6/1010
UR - email: Brendan.mason@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology of human P[8],G9 rotaviruses in Hungary between 1998 and 2001.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Schipp, R.
AU - Jakab, F.
AU - Bene, J.
AU - Melegh, B.
AU - Glass, R. I.
AU - Szücs, G.
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
Y1 - 2004///
VL - 53
IS - 8
SP - 791
EP - 801
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-2615
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20043135383. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - Increasing numbers of studies have documented the widespread distribution of human G9 rotaviruses and demonstrated that these strains may represent a fifth epidemiologically important G serotype. Serotype G9 strains were identified in Hungary for the first time in the 1997-1998 rotavirus season. Contrary to numerous surveys that reported several unexpected P-G combinations among recent G9 isolates (e.g. genotypes P[4], P[6] and P[19]), all Hungarian strains characterized to date possess the globally most common P-type, P[8], which was found among the first G9 isolates that were identified during the 1980s in the USA (WI61) and Japan (F45). To study the genetic variability within Hungarian G9 strains, RNA profile analysis and nucleotide sequencing were performed on a subset of samples that were collected between 1998 and 2001. These strains could be classified into four major RNA profiles, of which two were characteristic for epidemiologically major and two for epidemiologically minor G9 strains. Phylogenetic analysis demonstrated substantial sequence differences between the VP7 gene of Hungarian G9 strains and early strains that were isolated in the USA (WI61), Japan (F45) and India (116E) and a few recently identified isolates, e.g. from China (97'SZ37) and the USA (OM67) (<90% nucleotide sequence similarity). In contrast, the VP7 genes of Hungarian G9 strains were related very closely to the vast majority of G9 strains that were isolated in a variety of countries over the last several years (>96% nucleotide sequence similarity). With respect to the VP4 gene, Hungarian G9 rotaviruses fell into two of the major genetic lineages of genotype P[8], one corresponding to the epidemic strains (lineage II; P-like) and the other for two unique strains (lineage I; Wa-like), suggesting independent introduction of distinct P[8],G9 strains into Hungary or genetic reassortment between locally circulating P[8] strains and descendants of G9 isolates that were imported into the country at an earlier time. The unexpected heterogeneity found for G9 VP7 genes from several countries suggests that genetic variation among these strains has not yet been fully explored.
KW - DNA sequencing
KW - genetic variation
KW - genotypes
KW - heterogeneity
KW - molecular epidemiology
KW - phylogenetics
KW - serotypes
KW - strains
KW - Hungary
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043135383&site=ehost-live&scope=site
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Work-related pilot fatalities in agriculture - United States, 1992-2001.
AU - Struttmann, T. W.
AU - Marsh, S. M.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2004///
VL - 53
IS - 15
SP - 318
EP - 320
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Struttmann, T. W.: Div of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043090951. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Aircraft are used in agriculture to apply pesticides, herbicides or fertilizers. During 1992-2001, a total of 141 persons died of agriculture-related plane crashes. The Centers for Disease Control analysed data on fatal injuries to pilots working in US agriculture during 1992-2001. This report summarizes the results of the analysis, which indicated that agricultural pilots are at increased risk for fatal injury compared with pilots in all other countries.
KW - accidents
KW - agricultural aviation
KW - epidemiology
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043090951&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adult blood lead epidemiology and surveillance - United States, 2002.
AU - Roscoe, R. J.
AU - Graydon, J. R.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2004///
VL - 53
IS - 26
SP - 578
EP - 582
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Roscoe, R. J.: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043137065. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - This report presents Adult Blood Lead Epidemiology and Surveillance data for 2002, the first year that individual rather than summary data were collected. The 2002 data indicate that approximately 95% of adult lead exposures were occupational, 94% of those exposed were male, and 91% were aged 25-64 years. The findings also indicated that the national decline in the number of adults with elevated blood lead levels continued in 2002; however, even greater prevention activities, particularly in work environments, will be necessary to achieve the 2010 health objective.
KW - adults
KW - age
KW - blood
KW - epidemiology
KW - exposure
KW - lead
KW - lead poisoning
KW - men
KW - occupational hazards
KW - occupational health
KW - sex differences
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043137065&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changing patterns of pneumoconiosis mortality - United States, 1968-2000.
AU - Attfield, M. D.
AU - Wood, J. M.
AU - Antao, V. C.
AU - Pinheiro, G. A.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2004///
VL - 53
IS - 28
SP - 627
EP - 632
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Attfield, M. D.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043138896. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report describes the temporal patterns of pneumoconiosis mortality in the USA during 1968-2000, which indicates an overall decrease in pneumoconiosis mortality. The incidence of asbestosis increased steadily and it is now the most frequently recorded pneumoconiosis on death certificates.
KW - asbestosis
KW - dust
KW - epidemiology
KW - mortality
KW - pneumoconioses
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - pneumoconiosis
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043138896&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatal and nonfatal occupational injuries involving wood chippers - United States, 1992-2002.
AU - Struttmann, T. W.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2004///
VL - 53
IS - 48
SP - 1130
EP - 1131
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Struttmann, T. W.: Div of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043217158. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Public Health
N2 - To describe fatal and nonfatal injuries associated with wood chippers, CDC analysed 11 years of data from the Bureau of Labor Statistics Census of Fatal Occupational Injuries for 1992-2002. This report summarizes the results of that analysis, which indicate that those working with mobile wood chippers are at risk for serious injury and death, but that these injuries can be prevented through proper training, machine maintenance, and the use of personal protective equipment.
KW - epidemiology
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - trauma
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - traumas
KW - United States of America
KW - wood chippers
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043217158&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolism of daidzein by intestinal bacteria from rhesus monkeys (Macaca mulatta).
AU - Rafii, F.
AU - Hotchkiss, C.
AU - Heinze, T. M.
AU - Park, M.
JO - Comparative Medicine
JF - Comparative Medicine
Y1 - 2004///
VL - 54
IS - 2
SP - 165
EP - 169
CY - Memphis; USA
PB - American Association for Laboratory Animal Science
SN - 1532-0820
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043083081. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 486-66-8. Subject Subsets: Human Nutrition
N2 - Purpose: To identify the metabolites produced from an isoflavonoid, daidzein, by colonic bacteria of rhesus monkeys. Methods: The metabolism of daidzein by the fecal bacteria of nine monkeys was investigated. Daidzein was incubated anaerobically with fecal bacteria, and the metabolites were analyzed by use of liquid chromatography and mass spectrometry. Results: The fecal bacteria of all of the monkeys metabolized daidzein to various extents. Dihydrodaidzein was found in cultures of fecal bacteria from two monkeys; dihydrodaidzein and equol were found in cultures from four monkeys; dihydrodaidzein, equol, and an unknown metabolite (MW=244) were found in cultures from one monkey; and dihydrodaidzein and the unknown metabolite were found in cultures from two monkeys. Conclusions: Similar to that in humans, variation was evident in the metabolism of isoflavonoids by fecal bacteria from rhesus monkeys. Some metabolites produced by fecal bacteria from monkeys were the same as those produced by fecal bacteria from humans.
KW - animal models
KW - daidzein
KW - intestines
KW - laboratory animals
KW - lipid metabolism
KW - microbial flora
KW - Macaca mulatta
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fat metabolism
KW - microflora
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043083081&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preoperative screening of elective orthopaedic patients for MRSA.
AU - El-Zimaity, D.
AU - Dawson, S. J.
AU - Barrett, S.
AU - Moseley, E.
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
Y1 - 2004///
VL - 56
IS - 2
SP - 164
EP - 165
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0195-6701
AD - El-Zimaity, D.: Microbiology Carmarthenshire, National Public Health Service for Wales, West Wales General Hospital, Carmarthen, SA31 2AF, Wales, UK.
N1 - Accession Number: 20043029166. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 61-32-5. Subject Subsets: Public Health
N2 - In order to minimize infection with methicillin-resistant Staphylococcus aureus (MRSA), screening was introduced in elective orthopaedic patients attending the pre-assessment clinic at West Wales General Hospital, Carmarthen, Wales, UK. The patients were asked to answer a questionnaire to evaluate their risk factors for carriage for MRSA. 100 patients (47 males and 53 females) were screened between July 2002 and March 2003. Four patients, 2 males and 2 females, were colonized with MRSA. Three of 4 colonized patients were over 70 years old and the other patient was within the age group 41-50 years old. None of the colonized patients were previously colonized or infected with MRSA. Two of the screened patients lived in a residential home, neither of whom were colonized with MRSA. Three of the 4 colonized patients had been admitted within the past year. Three of the screened patients were recorded as living with a person known to be colonized or infected with MRSA, and one lived with a partner who worked in a hospital; none of these on screening was colonized with MRSA. 12 patients who had taken antibiotics in the previous month, and 2 of these were colonized with MRSA. 83 patients had not used antibiotics in the previous month, and 2 were colonized with MRSA.
KW - antibacterial agents
KW - bacterial diseases
KW - carrier state
KW - diagnosis
KW - drug resistance
KW - human diseases
KW - methicillin
KW - nosocomial infections
KW - orthopaedics
KW - preoperative care
KW - screening
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - hospital infections
KW - orthopedics
KW - screening tests
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043029166&site=ehost-live&scope=site
UR - email: dina.el-zimaity@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The estimated incidence of key food-borne illness among pregnant women in New Zealand.
AU - Pikholz, C.
AU - Simmons, G.
JO - Journal of the New Zealand Dietetic Association
JF - Journal of the New Zealand Dietetic Association
Y1 - 2004///
VL - 58
IS - 2
SP - 37
EP - 40
CY - Wellington; New Zealand
PB - New Zealand Dietetic Association Inc.
SN - 0110-635X
AD - Pikholz, C.: Auckland Regional Public Health Service, Auckland, New Zealand.
N1 - Accession Number: 20053011986. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health; Protozoology; Human Nutrition
N2 - Aim: To estimate the annual incidence of selected foodborne diseases among pregnant women in New Zealand. Methods: The diseases studied were campylobacteriosis, toxoplasmosis, salmonellosis, Yersinia infection, listeriosis and shigellosis. The estimates for all the diseases, except toxoplasmosis, were calculated from national surveillance data for the period 1996-1999, based on assumptions on the prevalence of pregnancy and using the same methods as published studies estimating the number of cases of communicable disease in New Zealand. The estimate for toxoplasmosis was taken from a published study using 1995 births data, with adjustment for the proportion of disease likely to be foodborne. Results: The estimates for the annual number of cases of foodborne diseases among pregnant women were (mean and range): campylobacteriosis, 715 (602-938); toxoplasmosis, 82 (65-102); salmonellosis, 58 (41-75); Yersinia infection, 18 (15-20); listeriosis, 5 (2-8); and shigellosis, 3 (2-4). Conclusions: Foodborne diseases are likely causes of morbidity during pregnancy. Doctors and midwives should be aware of the importance of foodborne diseases and its spectrum of presentation in pregnant women, and should investigate and treat appropriately. Nutritional advice given early in pregnancy should be accompanied by food safety advice.
KW - bacterial diseases
KW - campylobacteriosis
KW - disease incidence
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - foods
KW - human diseases
KW - listeriosis
KW - pregnancy
KW - salmonellosis
KW - shigellosis
KW - toxoplasmosis
KW - women
KW - New Zealand
KW - Campylobacter
KW - Listeria monocytogenes
KW - man
KW - Salmonella
KW - Shigella
KW - Toxoplasma
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - gestation
KW - listerellosis
KW - Salmonella infections
KW - Yersinia
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053011986&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - NMR regulatory analysis: determination and characterization of Chinese-herb aristolochic acids.
AU - Hanna, G. M.
JO - Pharmazie
JF - Pharmazie
Y1 - 2004///
VL - 59
IS - 3
SP - 170
EP - 174
CY - Eschborn; Germany
PB - Govi-Verlag, Pharmazeutischer Verlag GmbH
SN - 0031-7144
AD - Hanna, G. M.: Northeast Regional Laboratory, Food and Drug Administration, US Department of Health and Human Services, 158-15 Liberty Avenue, Jamaica, NY 11433-1034, USA.
N1 - Accession Number: 20043057534. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Ornamnental Horticulture
N2 - 1H NMR methodology for the simultaneous determination and characterization of the nephrotoxic components of Aristolochia plants, aristolochic acid I (AA-I) and aristolochic acid II (AA-II), was developed using a 400 MHz spectrometer without the need of reference standards. The developed methodology is able to differentiate and assess chemical structures of these toxic injurious compounds. The quantity of each was calculated on the basis of the integrals for the signals of the H-7 and H-8 of the phenanthrene ring of AA-I and AA-II at δ7.38 and δ8.31, respectively, and the vinylic protons of the internal standard maleic acid at δ6.06. The accuracy of the method was established through the analysis of synthetic mixtures containing the internal standard maleic acid, with purified AA-I or combined AA-I and AA-II sodium salts. Excellent agreements were verified between the assay results and the quantities in the mixtures. The mean±SD recovery values for purified AA-I and combined AA-I and AA-II from two sets of 10 synthetic mixtures were 99.8±0.6 and 99.6±0.8%, respectively. The assay of 4 lots of commercial aristolochic acid by 1H NMR spectroscopy indicated AA-I and AA-II contents in the ranges 45.3-97.1 and 0-15.4%, respectively.
KW - analytical methods
KW - chemical composition
KW - chemical structure
KW - medicinal plants
KW - nuclear magnetic resonance spectroscopy
KW - plant composition
KW - quantitative analysis
KW - techniques
KW - toxic substances
KW - traditional medicines
KW - Aristolochia
KW - Aristolochiaceae
KW - Aristolochiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - poisons
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043057534&site=ehost-live&scope=site
UR - email: ghanna@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - NMR regulatory analysis: determination and characterization of S-adenosyl-L-methionine in dietary supplements.
AU - Hanna, G. M.
JO - Pharmazie
JF - Pharmazie
Y1 - 2004///
VL - 59
IS - 4
SP - 251
EP - 256
CY - Eschborn; Germany
PB - Govi-Verlag, Pharmazeutischer Verlag GmbH
SN - 0031-7144
AD - Hanna, G. M.: Food and Drug Administration, Northeast Regional Laboratory, US Department of Health and Human Services, 158-15 Liberty Avenue, Jamaica, NY 11433-1034, USA.
N1 - Accession Number: 20043067910. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 63-68-3. Subject Subsets: Human Nutrition
N2 - 1H NMR methodology is described for the determination and characterization of the dietary supplement S-adenosyl-L-methionine (SAM), recently introduced to the US market, utilizing a 400 MHz spectrometer without the need of pure reference standards. The developed methodology is able to assess chemical structure, differentiate between biologically-active (S)-diastereomer and biologically-inactive (R)-diastereomer, and determine the ratio of each in the dietary supplement formulation. The determination of the percentage of declared SAM was based on the integrals for the methyl proton of 2-methyl-2-propanol served as an internal standard at δ 1.24 and the methine proton H1′ of SAM ribose ring at δ 6.06. The percentage of the active diastereomer was calculated from the relative intensities of the sulfonium methyl singlets corresponding to the major component (S)-diastereomer at δ 2.98 and the minor (R)-counterpart at δ 2.93. The accuracy was established by analyzing synthetic mixtures of the analyte and the internal standard. Excellent agreement was verified between the assay results and the quantities of analyte in the mixture. The mean±SD recovery values for SAM and its (R)-diastereomer impurity from a set of 10 synthetic mixtures were 99.6±0.8% and 22.5±0.1%, respectively. Using 10 lots, the percentage of SAM ranged from 0 to 110.7% of the declared value and the percentage of the active (S)-diastereomer ranged from 0 to 82.3%.
KW - analytical methods
KW - essential amino acids
KW - food supplements
KW - methionine
KW - molecular conformation
KW - nuclear magnetic resonance
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043067910&site=ehost-live&scope=site
UR - email: ghanna@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Do dietary intakes affect search for nutrient information on food labels?
AU - Lin ChungTung [Lin, C. T. J.]
AU - Lee JonqYing
AU - Yen, S. T.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2004///
VL - 59
IS - 9
SP - 1955
EP - 1967
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0277-9536
AD - Lin ChungTung [Lin, C. T. J.]: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-727, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043153841. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition
N2 - Nutrition labels on food packages are designed to promote and protect public health by providing nutrition information so that consumers can make informed dietary choices. High levels of total fat, saturated fat and cholesterol in diets are linked to increased blood cholesterol levels and a greater risk of heart disease. Therefore, an understanding of consumer use of total fat, saturated fat, and cholesterol information on food labels has important implications for public health and nutrition education. This study explores the association between dietary intakes of these three nutrients and psychological or demographic factors and the search for total fat, saturated fat, and cholesterol information on food labels. Psychology literature suggests a negative association between intakes of these nutrients and probability of search for their information on food labels. Health behavior theories also suggest perceived benefits and costs of using labels and perceived capability of using labels are associated with the search behavior. We estimate the relationship between label information search and its predictors using logistic regressions. Our samples came from the 1994-1996 Continuing Survey of Food Intakes by Individuals and Diet and Health Knowledge Survey conducted by the United States Department of Agriculture. Results suggest that search for total fat, saturated fat, and cholesterol information on food labels is less likely among individuals who consume more of the three nutrients, respectively. The search is also related to perceived benefits and costs of using the label, perceived capability of using the label, knowledge of nutrition and fats, perceived efficacy of diets in reducing the risk of illnesses, perceived importance of nutrition in food shopping, perceived importance of a healthy diet, and awareness of linkage between excessive consumption of the nutrients and health problems. These findings suggest encouraging search of food label information among consumers with unhealthy dietary habits would need innovative approaches. Yet, nutrition education can be instrumental in encouraging this search by stimulating motivation and providing technical help.
KW - attitudes
KW - cholesterol
KW - dietary fat
KW - food intake
KW - labelling
KW - nutrition information
KW - psychology
KW - saturated fats
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food labelling
KW - labeling
KW - labels
KW - psychological factors
KW - source fat
KW - United States of America
KW - Information and Documentation (CC300)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043153841&site=ehost-live&scope=site
UR - email: syen@utk.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gliomas and farm pesticide exposure in men: the upper midwest health study.
AU - Ruder, A. M.
AU - Waters, M. A.
AU - Butler, M. A.
AU - Carreón, T.
AU - Calvert, G. M.
AU - Davis-King, K. E.
AU - Schulte, P. A.
AU - Sanderson, W. T.
AU - Ward, E. M.
AU - Connally, L. B.
AU - Heineman, E. F.
AU - Mandel, J. S.
AU - Morton, R. F.
AU - Reding, D. J.
AU - Rosenman, K. D.
AU - Talaska, G.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 2004///
VL - 59
IS - 12
SP - 650
EP - 657
CY - Washington; USA
PB - Heldref Publications
SN - 0003-9896
AD - Ruder, A. M.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Mailstop R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063143494. Publication Type: Journal Article. Corporate Author: USA, Brain Cancer Collaborative Study Group Language: English. Number of References: 73 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - The National Institute for Occupational Safety and Health evaluated farm pesticide exposure and glioma risk in a study that included 457 glioma cases and 648 population-based controls, all adult men (18-80 yr old) and nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. Multiple logistic regressions were used to control for farm residence, age, age group, education, and exposure to other pesticides. No associations were found between glioma and 12 specific pesticides. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) and found reduced glioma risk for insecticides (OR=0.53, CI=0.37-0.77), fumigants (OR=0.57, CI=0.34-0.95), and organochlorines (OR=0.66, CI=0.47-0.94). In analyses excluding proxy respondents (47% of cases) most CIs included 1.0. No positive association of farm pesticide exposure and glioma was found. Other farm exposures may explain the excess brain cancer risk seen in previous studies.
KW - brain
KW - brain cancer
KW - exposure
KW - farmers
KW - fumigants
KW - glioma
KW - human diseases
KW - insecticides
KW - men
KW - neoplasms
KW - neuroglia
KW - occupational hazards
KW - occupational health
KW - organochlorine pesticides
KW - pesticides
KW - risk assessment
KW - risk factors
KW - Iowa
KW - Michigan
KW - Minnesota
KW - USA
KW - Wisconsin
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - cancers
KW - cerebrum
KW - glial cells
KW - organic chlorine pesticides
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063143494&site=ehost-live&scope=site
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality among a cohort of uranium mill workers: an update.
AU - Pinkerton, L. E.
AU - Bloom, T. F.
AU - Hein, M. J.
AU - Ward, E. M.
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
Y1 - 2004///
VL - 61
IS - 1
SP - 57
EP - 64
CY - London; UK
PB - BMJ Publishing Group
SN - 1351-0711
AD - Pinkerton, L. E.: Epidemiology Section, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043189836. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 7440-61-1. Subject Subsets: Public Health
N2 - Aims: To evaluate the mortality experience of 1484 men employed in seven uranium mills in the Colorado Plateau for at least one year on or after 1 January 1940. Methods: Vital status was updated through 1998, and life table analyses were conducted. Results: Mortality from all causes and all cancers was less than expected based on US mortality rates. A statistically significant increase in non-malignant respiratory disease mortality and non-significant increases in mortality from lymphatic and haematopoietic malignancies other than leukaemia, lung cancer, and chronic renal disease were observed. The excess in lymphatic and haematopoietic cancer mortality was due to an increase in mortality from lymphosarcoma and reticulosarcoma and Hodgkin's disease. Within the category of non-malignant respiratory disease, mortality from emphysema and pneumoconioses and other respiratory disease was increased. Mortality from lung cancer and emphysema was higher among workers hired prior to 1955 when exposures to uranium, silica, and vanadium were presumably higher. Mortality from these causes of death did not increase with employment duration. Conclusions: Although the observed excesses were consistent with our a priori hypotheses, positive trends with employment duration were not observed. Limitations included the small cohort size and limited power to detect a moderately increased risk for some outcomes of interest, the inability to estimate individual exposures, and the lack of smoking data. Because of these limitations, firm conclusions about the relation of the observed excesses in mortality and mill exposures are not possible.
KW - epidemiology
KW - Hodgkin's disease
KW - human diseases
KW - kidney diseases
KW - leukaemia
KW - lung cancer
KW - lymphosarcoma
KW - men
KW - mortality
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - pneumoconioses
KW - pulmonary emphysema
KW - respiratory diseases
KW - sarcoma
KW - toxic substances
KW - toxicity
KW - uranium
KW - workers
KW - Colorado
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - blood cancer
KW - cancer of the lymph nodes
KW - cancers
KW - death rate
KW - haematopoietic cancer
KW - kidney disorders
KW - leucaemia
KW - leukemia
KW - lung diseases
KW - lymphatic cancer
KW - lymphogranuloma
KW - nephropathy
KW - pneumoconiosis
KW - poisons
KW - renal diseases
KW - reticulosarcoma
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043189836&site=ehost-live&scope=site
UR - http://oem.bmjjournals.com/cgi/content/abstract/61/1/57
UR - email: LPinkerton@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular typing of Dientamoeba fragilis.
AU - Windsor, J. J.
AU - Clark, C. G.
AU - MacFarlane, L.
JO - British Journal of Biomedical Science
JF - British Journal of Biomedical Science
Y1 - 2004///
VL - 61
IS - 3
SP - 153
EP - 155
CY - Tunbridge Wells; UK
PB - Step Publishing Limited
SN - 0967-4845
AD - Windsor, J. J.: National Public Health Service for Wales Aberystwyth, Bronglais Hospital, Caradoc Road, Aberystwyth, Ceredigion SY23 3HF, UK.
N1 - Accession Number: 20043164887. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology
N2 - Dientamoeba fragilis isolates were typed using riboprinting to investigate the degree of genetic diversity in a large sample size. Over an 18-month period, 43 positive D. fragilis cultures were obtained. Small subunit ribosomal DNA genes (SSU-rDNAs) were amplified successfully from 33 of 43 lysates studied. Five lysates did not produce an amplification product and the amount of product in another five was too small to permit typing. The 33 amplified D. fragilis DNAs all produced the SSU-rDNA 1.7-kbp amplification product. After digestion with restriction enzymes, all 33 were found to have the same pattern (genotype 1). It is indicated that D. fragilis displays very little variation in its SSU-rDNA, and that genotype 2 is rare. It appears that riboprinting has limited value with D. fragilis.
KW - DNA
KW - DNA amplification
KW - genes
KW - genetic diversity
KW - genotypes
KW - ribosomal DNA
KW - Dientamoeba fragilis
KW - Dientamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - riboprinting
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043164887&site=ehost-live&scope=site
UR - email: jeff.windsor@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulatory frameworks for functional foods and dietary supplements.
AU - Taylor, C. L.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2004///
VL - 62
IS - 2
SP - 55
EP - 59
CY - Lawrence; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Taylor, C. L.: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20704, USA.
N1 - Accession Number: 20043053404. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - An understanding of the legal and regulatory requirements for foods, including dietary supplements and so-called functional foods, helps to focus attention on the special challenges that exist, which range from safety determinations to claim substantiation and consumer understanding. This article provides an overview of the US Food and Drug Administration's regulatory framework for these products; it also highlights issues that are emerging and will require consideration and dialog.
KW - consumer protection
KW - food safety
KW - food supplements
KW - functional foods
KW - law
KW - regulations
KW - reviews
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - legal aspects
KW - legal principles
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043053404&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modeling the level of fortification and post-fortification assessments: U.S. experience.
AU - Yetley, E. A.
AU - Rader, J. I.
A2 - Freire, W. B.
A2 - Howson, C. P.
A2 - Cordero, J. F.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2004///
VL - 62
IS - 6(2)
SP - S50
EP - S59
CY - Lawrence; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Yetley, E. A.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043129726. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 35 ref. Registry Number: 59-30-3. Subject Subsets: Human Nutrition; Public Health; Postharvest Research
N2 - Mandatory fortification of enriched cereal-grain products became effective in the United States on 1 January 1998. This fortification was undertaken to assist women of child-bearing age in increasing their intake of folic acid to reduce their risk of having a pregnancy affected by a neural tube birth defect. The process by which the Food and Drug Administration modelled the level of fortification with folic acid illustrates the complex issues and general principles that emerge when fortification of a nation's food supply is evaluated as a means of addressing a public health concern. The effectiveness of fortification for a target population and safety for the much larger general population impose conflicting challenges that must be considered concurrently when making decisions regarding fortification. Recent data show improved folate status and apparent decreases in risk of neural tube birth defects in the USA. Much about the long-term effects of the fortification program remains unknown and careful monitoring over time will be necessary to ensure that the program functions as intended.
KW - cereal grains
KW - congenital abnormalities
KW - folic acid
KW - food legislation
KW - fortification
KW - human diseases
KW - law
KW - nervous system diseases
KW - nutrition programmes
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - feeding programmes
KW - feeding programs
KW - folacin
KW - folate
KW - food programs
KW - legal aspects
KW - legal principles
KW - neural tube defect
KW - neuropathy
KW - nutrition programs
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Crop Produce (QQ050)
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043129726&site=ehost-live&scope=site
UR - email: Elizabeth.Yetley@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A θ-defensin composed exclusively of D-amino acids is active against HIV-1.
AU - Owen, S. M.
AU - Rudolph, D.
AU - Wang, W.
AU - Cole, A. M.
AU - Sherman, M. A.
AU - Waring, A. J.
AU - Lehrer, R. I.
AU - Lal, R. B.
JO - Journal of Peptide Research
JF - Journal of Peptide Research
Y1 - 2004///
VL - 63
IS - 6
SP - 469
EP - 476
CY - Copenhagen; Denmark
PB - Munksgaard International Publishers Ltd
SN - 1397-002X
AD - Owen, S. M.: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Public Health Services, US Department of Health and Human Services, Mail Stop D-12, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20043124280. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The ability of certain θ-defensins, including retrocyclin-1, to protect human cells from infection by HIV-1 marks them as potentially useful molecules. θ-Defensins composed of l-amino acids are likely to be unstable in environments that contain host and microbial proteases. This study compared the properties of two enantiomeric θ-defensins, retrocyclin-1, and RC-112. Although these peptides have identical sequences, RC-112 is composed exclusively of D-amino acids, whereas retrocyclin-1 contains only L-amino acids. We compared the ability of these peptides to protect JC53-BL human cells from infection by 30 primary HIV-1 isolates. JC53-BL cells are modified HeLa cells that express surface CD4, CXCR4, and CCR5. They also contain reporter cassettes that are driven by the HIV-1 LTR, and express β-galactosidase and luciferase. The HIV-1 isolates varied in co-receptor specificity and included subtypes A, B, C, D, CRF01-AE, and G. RC-112 was several fold more potent than retrocyclin-1 across the entire HIV-1 panel. Although RC-112 bound immobilized gp120 and CD4 with lower affinity than did retrocyclin-1, surface plasmon resonance experiments performed with 1 µg/mL of RC-112 and retrocyclin-1 revealed that both glycoproteins were bound to a similar extent. The superior antiviral performance of RC-112 most likely reflected its resistance to degradation by surface-associated or secreted proteases of the JC53-BL target cells. θ-Defensins composed exclusively of D-amino acids merit consideration as starting points for designing microbicides for topical application to the vagina or rectum.
KW - antiviral properties
KW - cell lines
KW - defensins
KW - HIV-1 infections
KW - human diseases
KW - peptides
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-viral properties
KW - human immunodeficiency virus type 1
KW - RC-112
KW - retrocyclin-1
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043124280&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/links/doi/10.1111/j.1399-3011.2004.00155.x/abs/
UR - email: smo2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermal inactivation of Enterobacter sakazakii in rehydrated infant formula.
AU - Edelson-Mammel, S. G.
AU - Buchanan, R. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 1
SP - 60
EP - 63
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Edelson-Mammel, S. G.: Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20043011709. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Dairy Science
N2 - The presence of low levels of Enterobacter sakazakii in dried infant formula have been linked to outbreaks of meningitis, septicemia, and necrotizing enterocolitis in neonates, particularly those who are premature or immunocompromised. In the current study, the ability of 12 strains of E. sakazakii to survive heating in rehydrated infant formula was determined at 58°C with a submerged coil apparatus. The observed D58-values ranged from 30.5-591.9 seconds, with the strains appearing to fall into 2 distinct heat resistance phenotypes. The z-value of the most heat-resistant strain was 5.6°C. When dried infant formula containing this strain was rehydrated with water preequilibrated to various temperatures, a more than 4-log reduction in E. sakazakii levels was achieved by preparing the formula with water at 70°C or greater.
KW - food contamination
KW - food safety
KW - heat resistance
KW - heat treatment
KW - inactivation
KW - infant formulae
KW - microbial contamination
KW - rehydration
KW - Enterobacter sakazakii
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - heat processing
KW - infant formula
KW - infant formulas
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043011709&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of on-board and dockside handling on the formation of biogenic amines in Mahimahi (Coryphaena hippurus), skipjack tuna (Katsuwonus pelamis), and yellowfin tuna (Thunnus albacares).
AU - Staruszkiewicz, W. F.
AU - Barnett, J. D.
AU - Rogers, P. L.
AU - Benner, R. A., Jr.
AU - Wong, L. L.
AU - Cook, J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 1
SP - 134
EP - 141
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Staruszkiewicz, W. F.: U.S. Food and Drug Administration, Washington Seafood Laboratory, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043011686. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 462-94-2, 51-45-6, 110-60-1.
N2 - Consumer illnesses by scombroid poisonings have been a continuing problem for many years. The intoxications follow the ingestion of fish such as tuna and mahimahi that have undergone bacterial decomposition, leading to the formation of biogenic amines. Research studies have concluded that histamine is one of the indicators of scombrotoxic fish and that other amines, such as cadaverine, could be involved in the illnesses. Guidance for the handling of fish on board fishing vessels to prevent the production of scombrotoxic fish has been limited by a lack of data addressing changes that occur in fish from the water to delivery at dockside. In this study, the changes in selected biogenic amines were determined in mahimahi and tuna, which were captured and held in seawater at 25-35°C for incubation times up to 18 hours. The fillets from the treated fish were sectioned by transverse cuts and analysed for histamine, cadaverine, and putrescine. The results showed that at 26°C, more than 12 hours of incubation were required before a histamine concentration of 50 ppm was reached in mahimahi. At 35°C, 50 ppm histamine formed within 9 hours. Similar results were found for skipjack and yellowfin tuna. Histamine concentrations exceeded 500 ppm within an additional 3 hours of incubation in mahimahi. At both temperatures, an increase in the concentration of cadaverine preceded an increase in histamine levels. Changes in putrescine concentrations in the fish were less pronounced. The study also demonstrated that histidine decarboxylase activity was retained in some frozen samples of fish and could result in further increases in histamine on thawing.
KW - biogenic amines
KW - cadaverine
KW - fish
KW - food contamination
KW - food handling
KW - food poisoning
KW - food safety
KW - food storage
KW - formation
KW - histamine
KW - microbial contamination
KW - putrescine
KW - Thunnus
KW - tuna
KW - Scombridae
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Thunnus
KW - 1,5-pentanediamine
KW - Coryphaena
KW - Coryphaena hippurus
KW - Coryphaenidae
KW - food contaminants
KW - Katsuwonus
KW - Katsuwonus pelamis
KW - Thunnus albacares
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043011686&site=ehost-live&scope=site
UR - email: wstarusz@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of the mouse bioassay and enzyme-linked immunosorbent assay procedures for the detection of type A botulinal toxin in food.
AU - Ferreira, J. L.
AU - Eliasberg, S. J.
AU - Edmonds, P.
AU - Harrison, M. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 1
SP - 203
EP - 206
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Ferreira, J. L.: U.S. Food and Drug Administration, 60 Eighth Street N.E., Atlanta, GA 30309, USA.
N1 - Accession Number: 20043011700. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Postharvest Research; Aromatic & Medicinal Plants
N2 - Samples of chili linked to a foodborne illness outbreak of type A botulism were examined for preformed type A botulinal toxin using 2 enzyme-linked immunosorbent assay (ELISA) procedures and the mouse bioassay. One of the samples was positive for type A botulinal toxin and 3 of the samples were negative for type A, B, E, and F botulinal toxins using the 3 methods. The mouse bioassay indicated that type A toxin was present at the 10 000 minimal lethal dose per gram (MLD per g) of product. The ELISA tests indicated a toxicity of 7650 MLD per g with one method and 8350 MLD per g with the other method. The sample toxicity determined by the ELISA was estimated by comparing samples to a standard curve generated with standard type A neurotoxin in casein buffer. The ELISA methods are more rapid than the mouse bioassay, since the toxin type can be determined in one day. The mouse bioassay is more sensitive than the ELISA but usually requires multiple assays to obtain the toxin type and toxicity. Type A culture isolates from the sample were also verified using one ELISA method.
KW - bioassays
KW - botulism
KW - chillies
KW - detection
KW - ELISA
KW - food contamination
KW - food safety
KW - microbial contamination
KW - toxins
KW - Capsicum
KW - Clostridium botulinum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043011700&site=ehost-live&scope=site
UR - email: jferreir@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibitory effects of ochratoxin A on nerve growth factor-induced neurite extension through downregulation of p38 MAP kinase and AP-1 activation in cultured pheochromocytoma cells.
AU - Oh JaeHo
AU - Jung HaiKwan
AU - Park YunJu
AU - Kim CheulKyu
AU - Chung SooYoun
AU - Park NamGyu
AU - Yun YoungWon
AU - Kim DaeJoong
AU - Ha TaeYoul
AU - Song YuenSook
AU - Lee YootMo
AU - Oh KiWan
AU - Hong JinTae
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2004///
VL - 67
IS - 4
SP - 357
EP - 371
CY - London; UK
PB - Taylor & Francis
SN - 1528-7394
AD - Oh JaeHo: Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20043029198. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 303-47-9. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Ochratoxin A (OTA) induces microcephaly in animals and in vitro cultured whole embryos. Inhibition of neuronal cell differentiation was proposed as underlying mechanisms responsible for OTA-induced microcephaly. Previously it was found that OTA inhibited differentiation of cultured rat embryonic midbrain cells into neurons. In this study, the influence of OTA on differentiation in PC-12 cells, a widely accepted model cells for study of neuronal differentiation was examined. Cell differentiation was assessed by measurement of neurite extension and quantified by the number of neurites extended. OTA decreased serum and nerve growth factor (NGF)-induced neurite extension in a concentration-dependent manner. Since MAP kinase and transcription factors have been implicated in cell differentiation of neuronal cells, and our previous study demonstrated that p38 MAP kinase and AP-1 are activated during PC 12 cell differentiation, the effect of OTA on NGF-induced p38 MAP kinase and transcription factor activation was examined. Co-treatment of OTA with NGF resulted in inhibition of NGF-induced p38 MAP kinase and AP-1 activation. Moreover, SB203580, a specific inhibitor of p38 MAP kinase blocked p38 MAP kinase and AP-1 activation accompanied by further inhibition of neurite extension. The present study shows that OTA inhibited cell differentiation of PC-12 cells, and this inhibitory effect may be related to inhibition of the activation of the p38 MAP kinase in conjunction with transcription factors AP-1. This finding suggests that the inhibitory effect on neuronal cell differentiation by OTA might be a mechanism responsible for OTA-induced microcephaly.
KW - brain
KW - cell lines
KW - disease models
KW - growth factors
KW - human diseases
KW - in vitro
KW - neurons
KW - ochratoxin A
KW - ochratoxins
KW - pathogenesis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - nerve cells
KW - neurones
KW - phaemochromocytoma
KW - Toxinology (VV820) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043029198&site=ehost-live&scope=site
UR - email: jinthong@cbucc.chungbuk.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antiviral flavonoids from the seeds of Aesculus chinensis.
AU - Wei Feng
AU - Ma ShuangCheng
AU - Ma LinYun
AU - But PuiHay [But, P. H. P.]
AU - Lin RuiChao
AU - Khan, I. A.
JO - Journal of Natural Products
JF - Journal of Natural Products
Y1 - 2004///
VL - 67
IS - 4
SP - 650
EP - 653
CY - Washington; USA
PB - American Chemical Society
SN - 0163-3864
AD - Wei Feng: National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing 100050, China.
N1 - Accession Number: 20043076685. Publication Type: Journal Article. Language: English. Number of References: 16 notes and ref. Subject Subsets: Forestry; Aromatic & Medicinal Plants; Botanical Pesticides; Tropical Diseases; Seed Science; Forest Products
N2 - A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10). The structures of the new compounds were elucidated by spectroscopic methods including 2D NMR. All compounds were tested for antiviral activity against respiratory syncytial virus (RSV), parainfluenza virus type 3 (PIV 3), and influenza virus type A (Flu A). Compounds 1, 2, and 6 showed significant antiviral activities against RSV with IC50 values of 4.5, 6.7, and 4.1 µg/mL and selective index (SI) values of 15.8, 32, and 63.8, respectively. Compound 8 demonstrated significant antiviral activity against Flu A with an IC50 of 24.5 µg/mL and a SI of 16.0, respectively.
KW - antiviral properties
KW - chemical composition
KW - chemical structure
KW - flavonoids
KW - medicinal plants
KW - non-wood forest products
KW - plant composition
KW - plant extracts
KW - seeds
KW - traditional medicines
KW - China
KW - Aesculus
KW - human respiratory syncytial virus
KW - influenzavirus A
KW - Hippocastanaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Orthomyxoviridae
KW - Aesculus
KW - Paramyxovirinae
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Aesculus chinensis
KW - anti-viral properties
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - parainfluenza 3 virus
KW - People's Republic of China
KW - Plant Composition (FF040)
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Non-wood Forest Products (KK540)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043076685&site=ehost-live&scope=site
UR - email: mashuangcheng@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid, specific detection of Salmonella Enteritidis in pooled eggs by real-time PCR.
AU - Seo, K. H.
AU - Valentin-Bon, I. E.
AU - Brackett, R. E.
AU - Holt, P. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 5
SP - 864
EP - 869
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Seo, K. H.: U.S. Food and Drug Administration, CFSAN/OPDFB, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20043083195. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - An assay was developed for the specific detection of Salmonella enteritidis in eggs with the use of an application of the fluorogenic 5′ nuclease assay (TaqMan). In this assay, a segment of the gene sefA specific to Salmonella group D strains such as S. enteritidis was used. The amplification of the target gene products was monitored in real-time by incorporating a fluorescent dye-labelled gene-specific probe in PCR (polymerase chain reaction). This method correctly detected and distinguished S. enteritidis from nearly 50 of non-group D Salmonella and other non-Salmonella strains. Detection of the sefA gene was linear for DNA extracted from approximately 102-109 CFU (colony-forming unit)/ml in phosphate-buffered saline and 103-108 CFU/ml in raw egg. In 2 trials, when applied to detection of S. enteritidis in homogenized egg pools and compared with conventional culture methods, the newly developed PCR method yielded a 100% correlation with results obtained by a conventional culture method. However, the PCR method required only 2 days, compared to the 5 days required by the culture method. The sensitivity of this assay was approximately less than 1 CFU/600 g of egg pool. The real-time PCR assay proved to be a rapid, highly sensitive test for detection and quantification of low concentrations of S. enteritidis in egg samples.
KW - detection
KW - DNA
KW - eggs
KW - food contamination
KW - food safety
KW - genes
KW - microbial contamination
KW - polymerase chain reaction
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - deoxyribonucleic acid
KW - food contaminants
KW - PCR
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043083195&site=ehost-live&scope=site
UR - email: kseo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative effectiveness of the Bacteriological Analytical Manual method for the recovery of Salmonella from whole cantaloupes and cantaloupe rinses with selected preenrichment media and rapid methods.
AU - Hammack, T. S.
AU - Valentin-Bon, I. E.
AU - Jacobson, A. P.
AU - Andrews, W. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 5
SP - 870
EP - 877
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Hammack, T. S.: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20043083196. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Horticultural Science; Agroforestry
N2 - Soak and rinse methods were compared for the recovery of Salmonella from whole cantaloupes. Cantaloupes were surface inoculated with Salmonella cell suspensions and stored for 4 days at 2 to 6°C. Cantaloupes were placed in sterile plastic bags with a nonselective preenrichment broth at a 1:1.5 cantaloupe weight-to-broth volume ratio. The cantaloupe broths were shaken for 5 minutes at 100 rpm after which 25-ml aliquots (rinse) were removed from the bags. The 25-ml rinses were preenriched in 225-ml portions of the same uninoculated broth type at 35°C for 24 h (rinse method). The remaining cantaloupe broths were incubated at 35°C for 24 h (soak method). The preenrichment broths used were buffered peptone water (BPW), modified BPW, lactose (LAC) broth, and universal preenrichment (UP) broth. The Bacteriological Analytical Manual Salmonella culture method was compared with the following rapid methods: the TECRA Unique Salmonella method, the VIDAS ICS/SLM method and the VIDAS SLM method. The soak method detected significantly more Salmonella-positive cantaloupes (P<0.05) than the rinse method: 367 Salmonella-positive cantaloupes of 540 test cantaloupes by the soak method and 24 Salmonella-positive cantaloupes of 540 test cantaloupes by the rinse method were detected. Overall, BPW, LAC, and UP broths were equal with respect to the recovery of Salmonella from cantaloupes. Both the VIDAS ICS/SLM and TECRA Unique Salmonella methods detected significantly fewer Salmonella-positive cantaloupes than the culture method: the VIDAS ICS/SLM method detected 23 of 50 Salmonella-positive cantaloupes (60 tested) and the TECRA Unique Salmonella method detected 16 of 29 Salmonella-positive cantaloupes (60 tested). The VIDAS SLM and culture methods were equivalent: both methods detected 37 of 37 Salmonella-positive cantaloupes (60 tested).
KW - cell suspensions
KW - culture media
KW - culture techniques
KW - cultures
KW - melons
KW - methodology
KW - soaking
KW - District of Columbia
KW - USA
KW - bacteria
KW - Cucumis melo
KW - Salmonella
KW - prokaryotes
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - methods
KW - United States of America
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043083196&site=ehost-live&scope=site
UR - email: Thomas.Hammack@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Bacillus spores using PCR and FTA filters.
AU - Lampel, K. A.
AU - Dyer, D.
AU - Kornegay, L.
AU - Orlandi, P. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 5
SP - 1036
EP - 1038
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Lampel, K. A.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD 20708, USA.
N1 - Accession Number: 20043083190. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Emphasis has been placed on developing and implementing rapid detection systems for microbial pathogens. In this study, the utility of expanding FTA filter technology for the preparation of template DNA for PCR (polymerase chain reaction) from bacterial spores was explored. Isolated spores from several Bacillus spp., B. subtilis, B. cereus and B. megaterium, were applied to FTA filters and specific DNA products were amplified by PCR. Spore preparations were examined microscopically to ensure that the presence of vegetative cells, if any, did not yield misleading results. PCR primers SRM86 and SRM87 targeted a conserved region of bacterial rRNA genes, whereas primers Bsub5F and Bsub3R amplified a product from a conserved sequence of the B. subtilis rRNA gene. With the use of the latter set of primers for nested PCR, the sensitivity of the PCR-based assay was increased. Overall, 53 spores could be detected after the first round of PCR, and the sensitivity was increased to 5 spores by nested PCR. FTA filters are an excellent platform to remove PCR inhibitors and have universal applications for environmental, clinical, and food samples.
KW - bacterial spores
KW - detection
KW - DNA
KW - filters
KW - polymerase chain reaction
KW - ribosomal RNA
KW - Bacillus cereus
KW - Bacillus megaterium
KW - Bacillus subtilis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bacillus
KW - bacterium
KW - deoxyribonucleic acid
KW - PCR
KW - rRNA
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043083190&site=ehost-live&scope=site
UR - email: klampel@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Baseline rates of Campylobacter and Salmonella in raw chicken in Wales, United Kingdom, in 2002.
AU - Meldrum, R. J.
AU - Tucker, D.
AU - Edwards, C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 6
SP - 1226
EP - 1228
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Food, Water and Environmental Section, Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20043109483. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition; Poultry
N2 - The Public Health Laboratory Service in Wales, in cooperation with local authorities and the Food Standards Agency Wales, carried out a survey to establish baseline figures for the contamination of raw retail chicken with Salmonella and Campylobacter available within Wales, a devolved part of the United Kingdom with a population of ~3 million. Seven hundred thirty-nine samples were obtained between November 2001 and December 2002. Overall, 71% of samples were contaminated with Campylobacter, and 8% were contaminated with Salmonella. There were no significant differences between fresh and frozen carcasses and between samples taken from retailers or butchers. There was seasonal variation in the level of Campylobacter contamination of fresh chicken, with a peak in June and the lowest positive rates in January, March, and December. There was no similar peak observed in frozen samples or for Salmonella.
KW - food contamination
KW - food safety
KW - microbial contamination
KW - poultry
KW - UK
KW - Wales
KW - Campylobacter
KW - fowls
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - United Kingdom
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043109483&site=ehost-live&scope=site
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modifications and adaptations of the Charm II rapid antibody assay for chloramphenicol in honey.
AU - McMullen, S. E.
AU - Lansden, J. A.
AU - Schenck, F. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 7
SP - 1533
EP - 1536
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - McMullen, S. E.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth Street N.E., Atlanta, GA 30309, USA.
N1 - Accession Number: 20043121452. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 56-75-7. Subject Subsets: Sugar Industry
N2 - The Charm II screening method for the presence of chloramphenicol in honey has a sensitivity of 0.3 ppb. This screening method is a simple, rapid antibody assay using [3H]chloramphenicol and a binding reagent. Analysis of different types of honey revealed considerable differences in results. Honey can be liquid, crystallized (creamed), or partially crystallized and is classified by the US Department of Agriculture into seven colour categories: water white, extra white, white, extra light amber, light amber, amber, and dark amber. Fortified and nonfortified liquid amber honey tested appropriately with the Charm II unit and the negative control provided with the unit after slight modifications were made. However, approximately 70% of creamed honey samples fortified at 0.6 ppb did not test positive for the presence of chloramphenicol using the provided negative control. Matrix quenching effects were evaluated, and these effects were accounted for by establishing different assay conditions for different honey types.
KW - antibiotic residues
KW - chloramphenicol
KW - drug residues
KW - honey
KW - methodology
KW - modification
KW - screening
KW - methods
KW - screening tests
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043121452&site=ehost-live&scope=site
UR - email: smcmulle@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential for internalization, growth, and survival of Salmonella and Escherichia coli O157:H7 in oranges.
AU - Eblen, B. S.
AU - Walderhaug, M. O.
AU - Edelson-Mammel, S.
AU - Chirtel, S. J.
AU - Jesus, A. de
AU - Merker, R. I.
AU - Buchanan, R. L.
AU - Miller, A. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 8
SP - 1578
EP - 1584
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Eblen, B. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20043141990. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science
N2 - Internalization potential, survival, and growth of human pathogens within oranges were investigated in a series of laboratory experiments. Submerging oranges into dye solutions at various temperature differentials was used to assess internalization potential. Conditions in which dye internalization was observed were further studied by applying Escherichia coli O157: H7 or Salmonella onto the stem scar, subjecting the oranges to a temperature differential, juicing, and measuring numbers of pathogens in the resulting juice. Pathogens for growth and survival studies were applied to or injected into simulated peel punctures. Oranges with small peel holes of selected sizes were also placed into solutions containing these pathogens. Bacterial survival was also evaluated in orange juice at 4 and 24°C. Oranges internalized pathogens at a frequency of 2.5 to 3.0%, which mirrored dye internalization frequency (3.3%). Pathogens were internalized at an uptake level of 0.1 to 0.01% of the challenge applied. Bacteria grew within oranges at 24°C, but not at 4°C. Thirty-one percent of oranges with 0.91-mm surface holes showed pathogen uptake, whereas 2% of oranges with 0.68-mm holes showed pathogen uptake. Pathogens added to fresh orange juice and incubated at 24°C declined 1 log CFU/ml within 3 days. These results suggest that internalization, survival, and growth of human bacterial pathogens can occur within oranges intended for producing unpasteurized juice.
KW - growth
KW - oranges
KW - survival
KW - temperature
KW - Citrus
KW - Citrus sinensis
KW - Escherichia coli
KW - Salmonella
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Citrus
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - Rutales
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Storage Problems and Pests of Food (QQ111)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043141990&site=ehost-live&scope=site
UR - email: beblen@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sulfites - a food and drug administration review of recalls and reported adverse events.
AU - Timbo, B.
AU - Koehler, K. M.
AU - Wolyniak, C.
AU - Klontz, K. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 8
SP - 1806
EP - 1811
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Timbo, B.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043142026. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - Sulfite-sensitive individuals can experience adverse reactions after consuming foods containing sulfiting agents (sulfites), and some of these reactions may be severe. In the 1980s and 1990s, the U.S. Food and Drug Administration (FDA) acted to reduce the likelihood that sulfite-sensitive individuals would unknowingly consume foods containing sulfites. The FDA prohibited the use of sulfites on fruits and vegetables (except potatoes) to be served or presented fresh to the public and required that the presence of detectable levels of sulfites be declared on food labels, even when these sulfites are used as a processing aid or are a component of another ingredient in the food. In the present study, data from FDA recall records and adverse event reports were used to examine the current status of problems of sensitivity to sulfites in foods. From 1996 through 1999, the FDA processed a total of 59 recalls of foods containing undeclared sulfites; these 59 recalls involved 93 different food products. Fifty (55%) of the recalled products were classified as class I, a designation indicating that a consumer reasonably could have ingested ≥10 mg of undeclared sulfites on a single occasion, a level that could potentially cause a serious adverse reaction in a susceptible person. From 1996 through mid-1999, the FDA received a total of 34 reports of adverse reactions allegedly due to eating foods containing undeclared sulfites. The average of 10 reports per year, although derived from a passive surveillance system, was lower than the average of 111 reports per year that the FDA received from 1980 to 1987, a decrease that may have resulted in part from FDA regulatory action.
KW - adverse effects
KW - food allergies
KW - food safety
KW - sulfites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - food hypersensitivity
KW - recall
KW - sulphites
KW - United States of America
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043142026&site=ehost-live&scope=site
UR - email: btimbo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Initiating and managing risk assessments within a risk analysis framework: FDA/CFSAN's practical approach.
AU - Buchanan, R. L.
AU - Dennis, S.
AU - Miliotis, M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 9
SP - 2058
EP - 2062
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Buchanan, R. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-06, 5100 Paint Branch Parkway 2B64, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043165665. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - The experiences of the US Food and Drug Administration Center for Food Safety and Applied Nutrition (CFSAN) in initiating and managing risk assessments is described. The key experiences identified and ultimately used to develop a practical framework for initiating and managing risk assessment include issues related to (1) commissioning a risk assessment, (2) interactions between risk managers and risk assessors, and (3) peer review.
KW - food contamination
KW - food safety
KW - microbial contamination
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043165665&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance risk assessment in food safety.
AU - Claycamp, H. G.
AU - Hooberman, B. H.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 9
SP - 2063
EP - 2071
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Claycamp, H. G.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7519 Standish Place, HFV 102, Rockville, MD 20855, USA.
N1 - Accession Number: 20043165666. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 53 ref. Subject Subsets: Human Nutrition
N2 - An overview of the basic elements of antimicrobial resistance risk assessment (ARRA) is presented. The objective was not to introduce or document ARRA policies by the US Food and Drug Administration; rather, the general theory and recent developments in ARRA are discussed. Distinctions between ARRA and the related activity of microbiological risk assessment are also discussed.
KW - antiinfective agents
KW - drug resistance
KW - food safety
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antimicrobials
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043165666&site=ehost-live&scope=site
UR - email: hclaycam@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - 1st International Conference on Microbiological Risk Assessment: Foodborne Hazards - what we heard.
AU - Buchanan, R. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 9
SP - 2072
EP - 2074
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Buchanan, R. L.: U.S. Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway 2B64, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043165667. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition
N2 - The different applications of microbiological risk assessment (MRA) techniques to a number of food safety issues, at both the national and international levels, are presented.
KW - food contamination
KW - food safety
KW - microbial contamination
KW - risk assessment
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043165667&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of intertidal exposure on Vibrio parahaemolyticus levels in Pacific Northwest oysters.
AU - Nordstrom, J. L.
AU - Kaysner, C. A.
AU - Blackstone, G. M.
AU - Vickery, M. C. L.
AU - Bowers, J. C.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 10
SP - 2178
EP - 2182
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Nordstrom, J. L.: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20043183487. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Animal Breeding
N2 - Interest in Vibrio parahaemolyticus (Vp) increased in the United States following Vp-associated gastroenteritis outbreaks in 1997 and 1998 involving the West Coast and other areas. The present study evaluated multiple aspects of Vp ecology in the Pacific Northwest with three objectives: (1) to determine the effect of low-tide exposure on Vp levels in oysters, (2) to determine the relationship between total and pathogenic Vp, and (3) to examine sediments and aquatic fauna as reservoirs for pathogenic Vp. Samples were collected from intertidal reefs along Hood Canal, Washington, USA, in August 2001. Faecal matter from marine mammals and aquatic birds as well as intestinal contents from bottom-dwelling fish were tested. Total and pathogenic Vp levels in all the samples were enumerated with colony hybridization procedures using DNA probes that targeted the thermolabile direct hemolysin (tlh) and thermostable direct hemolysin (tdh) genes, respectively. The mean Vp densities in oysters were four to eight times greater at maximum exposure than at the corresponding first exposure. While tdh-positive Vp counts were generally ≤10 CFU/g at first exposure, counts as high as 160 CFU/g were found at maximum exposure. Vp concentrations in sediments were not significantly different from those in oysters at maximum exposure. Pathogenic (tdh positive) Vp was detected in 9 of 42 (21%) oyster samples at maximum exposure, in 5 of 19 (26%) sediment samples, but in 0 of 9 excreta samples. These results demonstrate that summer conditions permit the multiplication of Vp in oysters exposed by a receding tide.
KW - food contamination
KW - marine ecology
KW - microbial contamination
KW - oysters
KW - seafoods
KW - seasonal variation
KW - USA
KW - Washington
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - bacterium
KW - food contaminants
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - Aquatic Biology and Ecology (MM300)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043183487&site=ehost-live&scope=site
UR - email: jessica.nordstrom@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Influence of fruit variety, harvest technique, quality sorting, and storage on the native microflora of unpasteurized apple cider.
AU - Keller, S. E.
AU - Chirtel, S. J.
AU - Merker, R. I.
AU - Taylor, K. T.
AU - Tan, H. L.
AU - Miller, A. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004///
VL - 67
IS - 10
SP - 2240
EP - 2247
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Keller, S. E.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Avenue, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20043183488. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Plant Breeding; Medical & Veterinary Mycology; Horticultural Science
N2 - Apple cultivar, harvest, quality sorting, and storage practices were evaluated to determine their impact on the microflora of unpasteurized cider. Seven apple cultivars (McIntosh, Gala, Golden Delicious, Red Delicious, Red Rome, Fuji and Granny Smith) were harvested from the tree or the ground. The apples were used fresh or were stored at 0 to 4°C for ≤5 months, and were pressed with or without quality selection. Cider yield, pH, Brix value, and titratable acidity were measured. Apples, postpressing apple pomace, and cider samples were analysed for aerobic bacteria, yeasts, and moulds. Aerobic bacterial plate counts (APCs) of ciders from fresh ground-picked apples (4.89 log CFU/ml) were higher than those of ciders made from fresh, tree-picked apples (3.45 log CFU/ml). Quality sorting further reduced the average APC to 2.88 log CFU/ml. Differences among all 3 treatment groups were significant (P<0.0001). Apple and pomace microbial concentrations revealed harvest and postharvest treatment-dependent differences similar to those found in cider. There were significant differences in APC among apple varieties (P=0.0001). Lower counts were associated with cultivars exhibiting higher Brix values and higher titratable acidity. Differences in APC for stored and fresh apples used for cider production were not significant (P>0.05). Yeast and mould counts revealed relationships similar to those for APCs. The relationship between initial microbial load found on incoming fruit and final cider microbial population was curvilinear, with the weakest correlations for the lowest apple microflora concentrations. The lack of linearity suggests that processing equipment contributed to cider contamination. Tree-picked quality fruits should be used for unpasteurized cider production, and careful manufacturing practices at cider plants can impact both safety and quality of the final product.
KW - apple pomace
KW - apples
KW - brix
KW - cider
KW - cold storage
KW - crop quality
KW - cultivars
KW - food contamination
KW - harvesting
KW - moulds
KW - pH
KW - titratable acidity
KW - yeasts
KW - bacteria
KW - Malus
KW - Malus pumila
KW - fungi
KW - eukaryotes
KW - prokaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Malus
KW - bacterium
KW - cultivated varieties
KW - food contaminants
KW - fungus
KW - hydrogen ion concentration
KW - molds
KW - potential of hydrogen
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Breeding and Genetics (FF020)
KW - Crop Produce (QQ050)
KW - Food Storage and Preservation (QQ110)
KW - Storage Problems and Pests of Food (QQ111)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043183488&site=ehost-live&scope=site
UR - email: robert.merker@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Building an organ-specific carcinogenic database for SAR analyses.
AU - Young, J. F.
AU - Tong, W. D.
AU - Fang, H.
AU - Xie, Q.
AU - Pearce, B.
AU - Hashemi, R.
AU - Beger, R. D.
AU - Cheeseman, M. A.
AU - Chen, J. J.
AU - Chang, Y. C. I.
AU - Kodell, R. L.
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2004///
VL - 67
IS - 17
SP - 1363
EP - 1389
CY - London; UK
PB - Taylor & Francis
SN - 1528-7394
AD - Young, J. F.: Division of Biometry and Risk Assessment, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043142929. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Public Health
N2 - FDA reviewers need a means to rapidly predict organ-specific carcinogenicity to aid in evaluating new chemicals submitted for approval. This research addressed the building of a database to use in developing a predictive model for such an application based on structure-activity relationships (SAR). The Internet availability of the Carcinogenic Potency Database (CPDB) provided a solid foundation on which to base such a model. The addition of molecular structures to the CPDB provided the extra ingredient necessary for SAR analyses. However, the CPDB had to be compressed from a multirecord to a single record per chemical database; multiple records representing each gender, species, route of administration, and organ-specific toxicity had to be summarized into a single record for each study. Multiple studies on a single chemical had to be further reduced based on a hierarchical scheme. Structural cleanup involved removal of all chemicals that would impede the accurate generation of SAR type descriptors from commercial software programs; that is, inorganic chemicals, mixtures and organometallics were removed. Counterions such as Na, K, sulfates, hydrates and salts were also removed for structural consistency. Structural modification sometimes resulted in duplicate records that also had to be reduced to a single record based on the hierarchical scheme. The modified database containing 999 chemicals was evaluated for liver-specific carcinogenicity using a variety of analysis techniques. These preliminary analyses all yielded approximately the same results with an overall predictability of about 63%, which was comprised of a sensitivity of about 30% and a specificity of about 77%.
KW - carcinogenesis
KW - carcinogens
KW - human diseases
KW - liver
KW - liver cancer
KW - neoplasms
KW - structure activity relationships
KW - toxic substances
KW - cancers
KW - poisons
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043142929&site=ehost-live&scope=site
UR - email: Jyoung@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mechanism of antifertility in male rats treated with 3-monochloro-1,2-propanediol (3-MCPD).
AU - Kwack SeungJun
AU - Kim SoonSun
AU - Choi YoWoo
AU - Rhee GyuSeek
AU - Lee RheeDa
AU - Seok JiHyun
AU - Chae SooYeong
AU - Won YongHyuck
AU - Lim KwonJo
AU - Choi KwangSik
AU - Park KuiLea
AU - Lee ByungMu
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2004///
VL - 67
IS - 23/24
SP - 2001
EP - 2011
CY - London; UK
PB - Taylor & Francis
SN - 1528-7394
AD - Kwack SeungJun: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, #5 Nokbun-dong, Eunpyung-ku, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20043198291. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 9000-83-3. Subject Subsets: Human Nutrition
N2 - 3-monochloro-1,2-propanediol (3-MCPD) is a food contaminant that is often found in foods containing acid-hydrolyzed (AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and hormonal levels, and its antifertility mechanism. In vivo male fertility testing was performed to observe the adverse effects of 3-MCPD on the functioning of the male reproductive system and pregnancy outcome. 3-MCPD (0.01-5 mg/kg) was administered daily by gavage to Sprague-Dawley (SD) male rats for 4 weeks. At the end of the pretreatment period, male rats were mated overnight with untreated females. Males successfully inducing pregnancy were sacrificed to assess sperm parameters, reproductive organ histopathology, and spermatogenesis. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. The paternal administration of 3-MCPD (5 mg/kg) resulted to adverse effects on male fertility and pregnancy outcome without inducing remarkable histopathological changes in the testes and epididymis. Additionally, 3-MCPD (5 mg/kg) significantly reduced sperm motility, copulation, fertility indices, and the number of live fetuses showed steep dose-response curves. 3-MCPD did not affect spermatogenesis or induce hormonal changes in the blood and testes of male rats. An in vitro hormone assay using primary isolated Leydig cells showed no significant changes in related hormone levels after 3-MCPD treatment. To evaluate the effects of 3-MCPD on apoptotic induction and H+-ATPase levels in the testis and epididymis, 10 or 100 mg/kg of 3-MCPD was administered by gavage to male rats and testes and epididymides were examined at 3, 6, 12 and 24 h later. Apoptosis was not detected in the testes of animals treated with 100 mg/kg 3-MCPD. However, the level of H+-ATPase in the cauda epididymis was reduced by 3-MCPD treatment. These results indicate that 3-MCPD induced a spermatotoxic effect, which was mediated by reduced H+-ATPase expression in the cauda epididymis, and suggest that an altered pH level in the cauda epididymis might lead to the disruption of sperm maturation and motility.
KW - adenosinetriphosphatase
KW - animal models
KW - apoptosis
KW - epididymis
KW - female animals
KW - fetus
KW - histopathology
KW - laboratory animals
KW - male animals
KW - male fertility
KW - pregnancy
KW - propanediols
KW - sex hormones
KW - spermatozoa
KW - testes
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 3-monochloro-1,2-propanediol
KW - ATPase
KW - foetus
KW - gestation
KW - sperm
KW - testicles
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043198291&site=ehost-live&scope=site
UR - email: parkkl@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening and behavioral counseling interventions in primary care to reduce alcohol misuse: recommendation statement.
JO - American Family Physician
JF - American Family Physician
Y1 - 2004///
VL - 70
IS - 2
SP - 353
EP - 358
CY - Leawood; USA
PB - American Academy of Family Physicians
SN - 0002-838X
AD - c/o Program Director, USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD 20850, USA.
N1 - Accession Number: 20043157991. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - This article summarizes the US Preventive Services Task Force recommendations on behavioural counselling interventions to reduce alcohol misuse in primary care patients and updates the 1996 recommendations contained in the 2nd edition of the Guide to Preventative Services.
KW - alcohol intake
KW - alcoholism
KW - counselling
KW - guidelines
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alcohol consumption
KW - counseling
KW - recommendations
KW - screening tests
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043157991&site=ehost-live&scope=site
UR - http://www.aafp.org/afp/20040715/us.html
UR - email: uspstf@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved laboratory enrichment for enterohemorrhagic Escherichia coli by exposure to extremely acidic conditions.
AU - Grant, M. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2004///
VL - 70
IS - 2
SP - 1226
EP - 1230
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Grant, M. A.: United States Food and Drug Administration, 22201 23rd Dr., SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20043043163. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - Analysis of food samples for E. coli O157:H7 using the standard U.S. Food and Drug Administration procedure is frequently complicated by overgrowth of nontarget microorganisms. A new procedure was developed for enrichment of enterohemorrhagic E. coli (EHEC) which utilizes exposure to pH 2.00 for 2 h. This procedure yielded larger populations of EHEC than the standard method by factors ranging from 2.7 to 7.7 and, when age-stressed cultures were used, by factors ranging from 2.7 to 11.5. Cultures of competing enterics were more effectively inhibited by the new enrichment protocol as well.
KW - acidification
KW - enrichment
KW - laboratory methods
KW - pH
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - hydrogen ion concentration
KW - laboratory techniques
KW - potential of hydrogen
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbiology (General) (ZZ390)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043043163&site=ehost-live&scope=site
UR - email: mgrant@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Distribution of Giardia duodenalis genotypes and subgenotypes in raw urban wastewater in Milwaukee, Wisconsin.
AU - Sulaiman, I. M.
AU - Jiang, J. L.
AU - Singh, A.
AU - Xiao, L. H.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2004///
VL - 70
IS - 6
SP - 3776
EP - 3780
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Sulaiman, I. M.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, Building 22, 4770 Buford Highway, Atlanta, GA 30341-3717, USA.
N1 - Accession Number: 20043108103. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Protozoology
N2 - Giardia cysts in 131 raw wastewater samples from Milwaukee, Wis., were genotyped by sequence analysis of the triosephosphate isomerase gene which showed the presence of two distinct genotypes (assemblages A and B) of Giardia duodenalis. Of the 131 samples, 111 belonged to assemblage A, and the remaining samples belonged to assemblage B. A high degree of genetic polymorphism was evident within the assemblage B cluster, with 10 distinct subgenotypes identified, eight of which have not been reported before.
KW - genetic polymorphism
KW - genotypes
KW - molecular genetics
KW - public health
KW - urban areas
KW - wastewater
KW - zoonoses
KW - USA
KW - Wisconsin
KW - Giardia duodenalis
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - Lake States of USA
KW - biochemical genetics
KW - United States of America
KW - waste water
KW - zoonotic infections
KW - Water Resources (PP200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043108103&site=ehost-live&scope=site
UR - email: lxiao@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bile-mediated aminoglycoside sensitivity in Lactobacillus species likely results from increased membrane permeability attributable to cholic acid.
AU - Elkins, C. A.
AU - Mullis, L. B.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2004///
VL - 70
IS - 12
SP - 7200
EP - 7209
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Elkins, C. A.: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Dr., Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20053002326. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 1405-87-4, 56-75-7, 81-25-4, 85721-33-1, 114-07-8, 1403-66-3, 1405-41-0, 8063-07-8, 859-18-7, 154-21-2, 389-08-2, 303-81-1, 82419-36-1, 13292-46-1, 57-92-1, 81-24-3, 516-50-7, 60-54-8, 64-75-5, 1404-90-6, 1404-93-9. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science
N2 - Few studies have been conducted on antimicrobial resistance in lactobacilli, presumably because of their nonpathogenic nature as anaerobic commensals. We assessed resistance in 43 type strains and isolates representing 14 species by using agar disk diffusion and MIC analysis in MRS medium. Most noteworthy were two general phenotypes displayed by nearly every strain tested: (i) they were more susceptible (up to 256-fold in some cases) to the deconjugated bile acid cholic acid than to the conjugate taurocholic or taurodeoxycholic acid, and (ii) they became susceptible to aminoglycosides when assayed on agar medium containing 0.5% fractionated bovine bile (ox gall). Two-dimensional MIC analyses of one representative strain, Lactobacillus plantarum WCFS1, at increasing concentrations of ox gall (0 to 30.3 mg/ml) displayed corresponding decreases in resistance to all of the aminoglycosides tested and ethidium bromide. This effect was clinically relevant, with the gentamicin MIC decreasing from >1,000 to 4 µg/ml in just 3.8 mg of ox gall per ml. In uptake studies at pH 6.5, [G-3H]gentamicin accumulation increased over control levels when cells of this strain were exposed to bile acids or reserpine but not when they were exposed to carbonyl cyanide m-chlorophenylhydrazone. The effect was dramatic, particularly with cholic acid, increasing up to 18-fold, whereas only modest increases, 3- and 5-fold, could be achieved with taurocholic acid and ox gall, respectively. Since L. plantarum, particularly strain WCFS1, is known to encode bile salt hydrolase (deconjugation) activity, our data indicate that mainly cholic acid, but not taurocholic acid, effectively permeabilizes the membrane to aminoglycosides. However, at pHs approaching neutral conditions in the intestinal lumen, aminoglycoside resistance due to membrane impermeability may be complemented by a potential efflux mechanism.
KW - aminoglycoside antibiotics
KW - antibacterial agents
KW - bacitracin
KW - bile acids
KW - cell membranes
KW - chloramphenicol
KW - cholic acid
KW - ciprofloxacin
KW - drug susceptibility
KW - erythromycin
KW - gentamicin
KW - kanamycin
KW - lincomycin
KW - membrane permeability
KW - multiple drug resistance
KW - nalidixic acid
KW - novobiocin
KW - ofloxacin
KW - rifampicin
KW - streptomycin
KW - taurocholic acid
KW - taurodeoxycholic acid
KW - tetracycline
KW - vancomycin
KW - Carnobacterium maltaromaticum
KW - Lactobacillus
KW - Lactobacillus acidophilus
KW - Lactobacillus delbrueckii
KW - Lactobacillus fermentum
KW - Lactobacillus gasseri
KW - Lactobacillus johnsonii
KW - Lactobacillus murinus
KW - Lactobacillus paracasei
KW - Lactobacillus plantarum
KW - Lactobacillus reuteri
KW - Lactobacillus ruminis
KW - Lactobacillus sakei
KW - Lactobacillus vaginalis
KW - Lactobacillaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Lactobacillus
KW - Carnobacterium
KW - Carnobacteriaceae
KW - achromycin
KW - bacterium
KW - Lactobacillus bifidus
KW - Lactobacillus maltaromicus
KW - lincocin
KW - rifampin
KW - rifamycin amp
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053002326&site=ehost-live&scope=site
UR - email: chris.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Macrophages release tumor necrosis factor alpha and interleukin-12 in response to intracellular Bacillus anthracis spores.
AU - Pickering, A. K.
AU - Merkel, T. J.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2004///
VL - 72
IS - 5
SP - 3069
EP - 3072
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Pickering, A. K.: Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, 29 Lincoln Dr., Bethesda, MD 20892, USA.
N1 - Accession Number: 20053097985. Publication Type: Journal Article. Language: English. Registry Number: 308079-78-9.
N2 - Herein we report that infection of a murine macrophage cell line with Bacillus anthracis results in the production of tumor necrosis factor alpha and interleukin-12 (IL-12). When infected with B. anthracis spores in combination with lipopolysaccharide, macrophages release increased amounts of IL-12. We found no evidence of inhibition of cytokine responses in macrophages infected with B. anthracis spores.
KW - bacterial spores
KW - cell lines
KW - cytokines
KW - disease models
KW - experimental infection
KW - interleukin 12
KW - interleukins
KW - laboratory animals
KW - lipopolysaccharides
KW - macrophages
KW - tumour necrosis factor
KW - Bacillus anthracis
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - cachectin
KW - cachexin
KW - experimental transmission
KW - tumor necrosis factor
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053097985&site=ehost-live&scope=site
UR - http://iai.asm.org/cgi/content/full/72/5/3069
UR - email: merkel@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cytokine response to infection with Bacillus anthracis spores.
AU - Pickering, A. K.
AU - Osorio, M.
AU - Lee, G. M.
AU - Grippe, V. K.
AU - Bray, M.
AU - Merkel, T. J.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2004///
VL - 72
IS - 11
SP - 6382
EP - 6389
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Pickering, A. K.: Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Dr., Bethesda, MD 20892, USA.
N1 - Accession Number: 20053102399. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 308079-78-9, 142298-00-8.
N2 - Bacillus anthracis, the etiological agent of anthrax, is a gram-positive, spore-forming bacterium. The inhalational form of anthrax is the most severe and is associated with rapid progression of the disease and the outcome is frequently fatal. Transfer from the respiratory epithelium to regional lymph nodes appears to be an essential early step in the establishment of infection. This transfer is believed to occur by means of carriage within alveolar macrophages following phagocytosis. Therefore, the ability of B. anthracis to transit through the host macrophage or dendritic cell appears to be an early and critical step in B. anthracis pathogenesis. In this work, we examined the cytokine responses to spore infection in mouse primary peritoneal macrophages, in primary human dendritic cells, and during a spore aerosol infection model utilizing the susceptible A/J mouse strain. We demonstrated that both mouse peritoneal macrophages and human dendritic cells exhibited significant intracellular bactericidal activity during the first hours following uptake, providing the necessary time to mount a cytokine response prior to cell lysis. Strong tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) responses were seen in mouse peritoneal macrophages. In addition to TNF-α and IL-6, human dendritic cells produced the cytokines IL-1β, IL-8, and IL-12. A mixture of Th1 and Th2 cytokines were detected in sera obtained from infected animals. In this study, we provide further evidence of an acute cytokine response when cells in culture and mice are infected with B. anthracis spores.
KW - animal models
KW - anthrax
KW - bacterial spores
KW - cell cultures
KW - experimental infection
KW - immune response
KW - interleukin 1
KW - interleukin 12
KW - interleukin 6
KW - interleukin 8
KW - laboratory animals
KW - macrophages
KW - tumour necrosis factor
KW - Bacillus anthracis
KW - man
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - bacterium
KW - cachectin
KW - cachexin
KW - experimental transmission
KW - immunity reactions
KW - immunological reactions
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053102399&site=ehost-live&scope=site
UR - http://iai.asm.org/cgi/content/abstract/72/11/6382
UR - email: merkel@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - One-year survey of astrovirus infection in children with gastroenteritis in a large hospital in Hungary: occurrence and genetic analysis of astroviruses.
AU - Jakab, F.
AU - Meleg, E.
AU - Bányai, K.
AU - Melegh, B.
AU - Tímár, L.
AU - Péterfai, J.
AU - Szucs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2004///
VL - 74
IS - 1
SP - 71
EP - 77
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Jakab, F.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20043162392. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Public Health
N2 - Human astroviruses (HAstV) are the causative agents of viral gastroenteritis mainly in children worldwide. This study investigated the epidemiology and genotype diversity of HAstVs detected in children admitted to hospital with gastroenteritis in Hungary. Stool samples were collected from children with diarrhea at the Municipal "Szent László" Hospital, Budapest, Hungary, between January 2002 and December 2002. Of 2,758 samples, 607 were negative for both rotaviruses and bacterial pathogens and were tested for astroviruses using a reverse transcriptase-polymerase chain reaction (RT-PCR) targeting the open reading frame (ORF2), capsid region. Astrovirus was detected in 10 samples (1.6%) by RT-PCR. Astrovirus infection was more frequent among children 49 to 60 months of age. Genotyping of positive samples was performed by type-specific RT-PCR and confirmed by sequence analysis. Phylogenetic analysis was performed using a 203 nucleotide consensus length of the 3′-end of the capsid gene. Type-specific RT-PCR and sequence analysis detected genotypes 1 (50%), 4 (30%), 3 (10%), and 8 (10%) among the children admitted to hospital. Genotype 1 was the predominant genotype, but genotypes 3, 4, and 8 were also present indicating the importance of emerging genotype 8 infections. Two distinct genotype 4 variants were observed during this study. Sequence analysis confirmed type-specific RT-PCR results in the capsid region. This is the first comprehensive report on the occurrence of HAstV infections in Central/Eastern Europe.
KW - amino acid sequences
KW - analytical methods
KW - children
KW - coat proteins
KW - gastroenteritis
KW - genotypes
KW - human diseases
KW - human faeces
KW - molecular genetics
KW - open reading frames
KW - polymerase chain reaction
KW - techniques
KW - viral diseases
KW - Hungary
KW - Astroviridae
KW - man
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - analytical techniques
KW - Astrovirus
KW - biochemical genetics
KW - capsid proteins
KW - human feces
KW - ORFs
KW - PCR
KW - protein sequences
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043162392&site=ehost-live&scope=site
UR - email: jakabf@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of perchlorate anion in foods by ion chromatography-tandem mass spectrometry.
AU - Krynitsky, A. J.
AU - Niemann, R. A.
AU - Nortrup, D. A.
JO - Analytical Chemistry (Washington)
JF - Analytical Chemistry (Washington)
Y1 - 2004///
VL - 76
IS - 18
SP - 5518
EP - 5522
CY - Washington; USA
PB - American Chemical Society
SN - 0003-2700
AD - Krynitsky, A. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043170066. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Dairy Science; Postharvest Research; Human Nutrition
N2 - A rapid, sensitive, and specific method was developed for determining perchlorate anion in lettuce, cantaloupe, bottled water, and milk. A test portion of chopped crop homogenate was extracted with diluted nitric acid and filtered. Milk proteins were precipitated with acetonitrile, and the supernatant, after centrifugation, was cleaned up on a graphitized carbon solid-phase extraction column. Water samples were analyzed directly. All test solutions were syringe filtered and mixed with an 18O4-labeled perchlorate internal standard before ion chromatography-tandem mass spectrometry. A strong anion exchange column eluted with 100 mM ammonium acetate in 50:50 (v/v) acetonitrile/water was interfaced via electrospray ionization to a triple stage quadrupole mass spectrometer operated in the negative ion mode. The labeled internal standard corrected for any sample matrix effects on measured signals. Four parent-to-product ion transitions, for loss of oxygen, were monitored for native and 18O4-labeled perchlorate anion, respectively: 35Cl-perchlorate, m/z 99 -> 83 and 107 -> 89; 37Cl-perchlorate, m/z 101 -> 85 and 109 -> 91. The limit of quantitation was 1.0 µg/kg in lettuce, 2.0 µg/kg in cantaloupe, 0.50 µg/L in bottled water, and 3.0 µg/L in milk. Native perchlorate was recovered from fortified test portions in the range 93-107% for lettuce, 107-114% for cantaloupe, 100-115% for bottled water, and 99-101% for milk.
KW - analytical methods
KW - bottled water
KW - chromatography
KW - determination
KW - food contamination
KW - lettuces
KW - mass spectrometry
KW - melons
KW - milk
KW - perchlorates
KW - Cucumis melo
KW - Lactuca sativa
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - analytical techniques
KW - food contaminants
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043170066&site=ehost-live&scope=site
UR - email: Alex.Krynitsky@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contribution of disulfide bridging to epitope expression of the dengue type 2 virus envelope glycoprotein.
AU - Roehrig, J. T.
AU - Volpe, K. E.
AU - Squires, J.
AU - Hunt, A. R.
AU - Davis, B. S.
AU - Chang, G. J. J.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004///
VL - 78
IS - 5
SP - 2648
EP - 2652
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Roehrig, J. T.: Arbovirus Disease Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053098497. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology; Tropical Diseases
N2 - The individual contributions of each of the six conserved disulfide (SS) bonds in the dengue 2 virus envelope (E) glycoprotein (strain 16681) to epitope expression was determined by measuring the reactivities of a panel of well-defined monoclonal antibodies (MAbs) with LLC-MK2 cells that had been transiently transformed with plasmid vectors expressing E proteins that were mutant in their SS bonds. Three domain I (DI) epitopes (C1, C3, and C4) were affected by elimination of any SS bond and were essentially the only epitopes affected by elimination of the amino-proximal SS1 formed between Cys 3 and Cys 30. The remaining DI epitope (C2) was sensitive to only SS3-bond (Cys 74-Cys 105) and SS6-bond (Cys 302-Cys 333) elimination. Of the four DII epitopes examined, reactivities of three anti-epitope MAbs (A1, A2, and A5) were reduced by elimination of SS2 (Cys 61-Cys 121), SS3, SS4 (Cys 94-Cys 116), SS5 (Cys 185-Cys 285), or SS6. The other DII epitope examined (A3) was sensitive only to SS2- and SS3-bond elimination. The three DIII epitopes tested (B2, B3, and B4) were most sensitive to elimination of SS6. The flavivirus group epitope (A1) was less sensitive to elimination of SS3 and SS6. This result may indicate that the region proximal to the E-protein fusion motif (amino acids 98 to 110) may have important linear components. If this observation can be confirmed, peptide mimics from this region of E protein might be able to interfere with flavivirus replication.
KW - envelope glycoproteins
KW - epitopes
KW - monoclonal antibodies
KW - strains
KW - sulfides
KW - viral antigens
KW - viral proteins
KW - dengue 2 virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenic determinants
KW - disulfide bonds
KW - sulphides
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053098497&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/content/full/78/5/2648
UR - email: jtr1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin D fortification in the United States and Canada: current status and data needs.
AU - Calvo, M. S.
AU - Whiting, S. J.
AU - Barton, C. N.
A2 - Raiten, D. J.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2004///
VL - 80
IS - 6(S)
SP - 1710S
EP - 1716S
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Calvo, M. S.: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, CFSAN, MOD-1, Building 8301, Muirkirk Road, Laurel, MD 20910, USA.
N1 - Accession Number: 20053007480. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 65 ref. Registry Number: 1406-16-2. Subject Subsets: Dairy Science; Human Nutrition
N2 - Most circulating 25-hydroxyvitamin D originates from exposure to sunlight; nevertheless, many factors can impair this process, necessitating periodic reliance on dietary sources to maintain adequate serum concentrations. The US and Canadian populations are largely dependent on fortified foods and dietary supplements to meet these needs, because foods naturally rich in vitamin D are limited. Fluid milk and breakfast cereals are the predominant vehicles for vitamin D in the USA, whereas Canada fortifies fluid milk and margarine. Reports of a high prevalence of hypovitaminosis D and its association with increased risks of chronic diseases have raised concerns regarding the adequacy of current intake levels and the safest and most effective way to increase vitamin D intake in the general population and in vulnerable groups. The usual daily intakes of vitamin D from food alone and from food and supplements combined, as estimated from the US 3rd National Health and Nutrition Examination Survey, 1988-94, show median values above the adequate intake of 5 µg/day for children 6-11 years of age; however, median intakes are generally below the adequate intake for female subjects >12 years of age and men >50 years. In Canada, there are no national survey data for estimation of intake. Cross-sectional studies suggest that current US/Canadian fortification practices are not effective in preventing hypovitaminosis D, particularly among vulnerable populations during the winter, whereas supplement use shows more promise. Recent prospective intervention studies with higher vitamin D concentrations provided evidence of safety and efficacy for fortification of specific foods and use of supplements.
KW - breakfast cereals
KW - children
KW - diets
KW - food supplements
KW - foods
KW - margarine
KW - milk
KW - nutrient intake
KW - risk
KW - solar radiation
KW - vitamin D
KW - Canada
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - 25-hydroxyvitamin D
KW - fortified foods
KW - hypovitaminosis D
KW - sunlight
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053007480&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: mona.calvo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Total arsenic determination and speciation in infant food products by ion chromatography-inductively coupled plasma-mass spectrometry.
AU - Vela, N. P.
AU - Heitkemper, D. T.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 1
SP - 244
EP - 252
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Vela, N. P.: Forensic Chemistry Center, U.S. Food and Drug Administration, 6751 Steger Dr, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20043054690. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 7440-38-2. Subject Subsets: Dairy Science; Horticultural Science
N2 - Health risk associated with dietary arsenic intake may be different for infants and adults. Seafood is the main contributor to arsenic intake for adults while terrestrial-based food is the primary source for infants. Processed infant food products such as rice-based cereals, mixed rice/formula cereals, milk-based infant formula, applesauce and purée of peaches, pears, carrots, sweet potatoes, green beans, and squash were evaluated for total and speciated arsenic content. Arsenic concentrations found in rice-based cereals (63-320 ng/g dry weight) were similar to those reported for raw rice. Results for the analysis of powdered infant formula by inductively coupled plasma-mass spectrometry (ICP-MS) indicated a narrow and low arsenic concentration range (12 to 17 ng/g). Arsenic content in purée infant food products, including rice cereals, fruits, and vegetables, varies from <1 to 24 ng/g wet weight. Sample treatment with trifluoroacetic acid at 100°C were an efficient and mild method for extraction of arsenic species present in different food matrixes as compared to alternative methods that included sonication and accelerated solvent extraction. Extraction recoveries from 94 to 128% were obtained when the summation of species was compared to total arsenic. The ion chromatography (IC)-ICP-MS method selected for arsenic speciation allowed for the quantitative determination of inorganic arsenic [As(III)+As(V)], dimethylarsinic acid (DMA), and methylarsonic acid (MMA). Inorganic arsenic and DMA are the main species found in rice-based and mixed rice/formula cereals, although traces of MMA were also detected. Inorganic arsenic was present in freeze-dried sweet potatoes, carrots, green beans, and peaches. MMA and DMA were not detected in these samples. Arsenic species in squash, pears, and applesauce were not detected above the method detection limit [5 ng/g dry weight for As(III), MMA, and DMA and 10 ng/g dry weight for As(V)].
KW - analytical methods
KW - arsenic
KW - carrots
KW - cereal products
KW - fruit products
KW - infant foods
KW - infant formulae
KW - ion exchange chromatography
KW - mass spectrometry
KW - peaches
KW - pears
KW - quantitative analysis
KW - quantitative techniques
KW - squashes
KW - sweet potatoes
KW - Cucurbita
KW - Daucus carota
KW - Ipomoea batatas
KW - Phaseolus vulgaris
KW - Prunus persica
KW - Pyrus
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - Ipomoea
KW - Convolvulaceae
KW - Solanales
KW - Phaseolus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Prunus
KW - Rosaceae
KW - Rosales
KW - analytical techniques
KW - Araliales
KW - baby foods
KW - green bean
KW - infant formula
KW - infant formulas
KW - pear
KW - snap bean
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043054690&site=ehost-live&scope=site
UR - email: nohora.vela@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preparation of peanut butter suspension for determination of peanuts using enzyme-linked immunoassay kits.
AU - Trucksess, M. W.
AU - Brewer, V. A.
AU - Williams, K. M.
AU - Westphal, C. D.
AU - Heeres, J. T.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 2
SP - 424
EP - 428
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20043081138. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 9000-11-7, 9004-32-4, 54-64-8. Subject Subsets: Dairy Science; Human Nutrition
N2 - Peanuts are one of the 8 most common allergenic foods and a large proportion of peanut-allergic individuals have severe reactions, some to minimal exposure. Specific protein constituents in the peanuts are the cause of the allergic reactions in sensitized individuals who ingest the peanuts. To avoid accidental ingestion of peanut-contaminated food, methods of analysis for the determination of the allergenic proteins in foods are important tools. Such methods could help identify foods inadvertently contaminated with peanuts, thereby reducing the incidence of allergic reactions to peanuts. Commercial immunoassay kits are available but need study for method performance, which requires reference materials for within- and between-laboratory validations. In this study, National Institute of Standards and Technology Standard Reference Material 2387 peanut butter was used. A polytron homogenizer was used to prepare a homogenous aqueous Peanut Butter suspension for the evaluation of method performance of some commercially available immunoassay kits such as Veratox for Peanut Allergen Test (Neogen Corp.), Ridascreen Peanut (R-Biopharm GmbH), and Bio-Kit Peanut Protein Assay Kit (Tepnel). Each gram of the aqueous peanut butter suspension contained 20 mg carboxymethylcellulose sodium salt, 643 µg peanut, 0.5 mg thimerosal, and 2.5 mg bovine serum albumin. The suspension was homogenous, stable, reproducible, and applicable for adding to ice cream, cookies, breakfast cereals, and chocolate for recovery studies at spike levels ranging from 12 to 90 µg/g.
KW - allergens
KW - bovine serum albumin
KW - breakfast cereals
KW - carboxymethylcellulose
KW - chocolate
KW - cookies
KW - ELISA
KW - groundnut butter
KW - groundnut protein
KW - groundnuts
KW - ice cream
KW - thiomersal
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - enzyme linked immunosorbent assay
KW - merthiolate
KW - peanut butter
KW - peanut protein
KW - peanuts
KW - sodium ethylmercurithiosalicylate
KW - thimerosal
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043081138&site=ehost-live&scope=site
UR - email: mary.trucksess@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Overview of infrared methodologies for trans fat determination.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Delmonte, P.
AU - Kramer, J. K. G.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 2
SP - 540
EP - 544
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mossoba, M. M.: Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS 717, BE-012, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20043081151. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Human Nutrition
N2 - trans Fatty acids are present in a variety of foods like dairy products, but the major sources are products that contain commercially hydrogenated fats. Some studies have shown that trans fatty acids elevate levels of serum low-density lipoprotein (LDL)-cholesterol and lower high-density lipoprotein (HDL)-cholesterol. The quantitation and identification of trans fatty acid isomers is difficult because of the wide range of positional monoene, diene, and triene fatty acid isomers present in hydrogenated oils. This is complicated by the cis positional isomers that are also present, as well as the lack of commercial chromatographic standards for many fatty acid isomers. In this review, infrared methodologies for the determination of total trans fat are presented. Using an attenuated total reflection (ATR) infrared cell, a novel Fourier transform infrared (FTIR) spectroscopic method that was developed for the rapid (5 min) quantitation of the total trans fatty acid levels in neat (without solvent) fats and oils measured as triacylglycerols (TAG) is discussed. TAG required no derivatization, but had to be melted prior to measurement. The lower limit of trans quantitation was 5% of total fat. The precision of this ATR method was found to be superior to that of transmission infrared official methods. Accuracy was enhanced by generating a symmetric absorption trans infrared band at 966 cm-1 on a horizontal background. This was achieved by "ratioing" the single-beam spectrum of the trans-containing fat or oil against that of a reference oil or standard having only cis double bonds. Attempts to apply this ATR-FTIR method to food matrixes with low trans fat and/or low total fat content were not satisfactory due to interfering infra-red absorptions in the trans region. To overcome this interference, the method was modified by applying the standard addition technique to the ATR-FTIR determination. The modified procedure required more time, but eliminated any adverse impact on accuracy arising from interfering minor food components having absorption bands near 966 cm-1.
KW - analytical methods
KW - fats
KW - infrared radiation
KW - oils
KW - reviews
KW - trans fatty acids
KW - triacylglycerols
KW - analytical techniques
KW - Fourier Transform infrared spectroscopy
KW - triglycerides
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043081151&site=ehost-live&scope=site
UR - email: mmossoba@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variation of analytical results for peanuts in energy bars and milk chocolate.
AU - Trucksess, M. W.
AU - Whitaker, T. B.
AU - Slate, A. B.
AU - Williams, K. M.
AU - Brewer, V. A.
AU - Whittaker, P.
AU - Heeres, J. T.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 4
SP - 943
EP - 949
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20043126571. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Peanuts contain proteins that can cause severe allergic reactions in some sensitized individuals. Studies were conducted to determine the percentage of recovery by an ELISA method in the analysis for peanuts in energy bars and milk chocolate and to determine the sampling, subsampling, and analytical variances associated with testing energy bars and milk chocolate for peanuts. Food products containing chocolate were selected because their composition makes sample preparation for subsampling difficult. Peanut-contaminated energy bars, noncontaminated energy bars, incurred milk chocolate containing known levels of peanuts, and peanut-free milk chocolate were used. A commercially available ELISA kit was used for analysis. The sampling, sample preparation, and analytical variances associated with each step of the test procedure to measure peanut protein were determined for energy bars. The sample preparation and analytical variances were determined for milk chocolate. Variances were found to be functions of peanut concentration. Sampling and subsampling variability associated with energy bars accounted for 96.6% of the total testing variability. Subsampling variability associated with powdered milk chocolate accounted for >60% of the total testing variability. The variability among peanut test results can be reduced by increasing sample size, subsample size, and number of analyses. For energy bars the effect of increasing sample size from 1 to 4 bars, subsample size from 5 to 20 g, and number of aliquots quantified from 1 to 2 on reducing the sampling, sample preparation, and analytical variance was demonstrated. For powdered milk chocolate, the effects of increasing subsample size from 5 to 20 g and number of aliquots quantified from 1 to 2 on reducing sample preparation and analytical variances were demonstrated. This study serves as a template for application to other foods, and for extrapolation to different sizes of samples and subsamples as well as numbers of analyses.
KW - allergens
KW - analytical methods
KW - ELISA
KW - food composition
KW - groundnut protein
KW - groundnuts
KW - milk chocolate
KW - recovery
KW - sample processing
KW - sampling
KW - subsampling
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - enzyme linked immunosorbent assay
KW - peanut protein
KW - peanuts
KW - preparation of samples
KW - sampling techniques
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043126571&site=ehost-live&scope=site
UR - email: mtruckse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of St. John's wort components in functional foods.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 5
SP - 1042
EP - 1048
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Jager, L. S. de: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20043172965. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants
N2 - A method was developed for determination of St. John's wort marker compounds hypericin, pseudohypericin, hyperforin, and adhyperforin in functional foods. Solid-phase extraction provided analyte extraction and significant sample cleanup prior to analysis using liquid chromatography (LC) with UV and fluorescence detection. In addition to quantification using LC-UV, confirmation was made with electrospray ionization LC mass spectrometry (LC/MS). Several commercially available tea and drink products claiming to contain St. John's wort were tested. Recoveries ranged from 51 to 98% for the liquid samples. Comparison of the concentrations in 4 St. John's wort teas showed a variation in analyte concentration (1044-10 ng/mL marker compounds in brewed tea) and composition. No marker compounds were found in the beverages, indicating possible decomposition of the marker compounds caused by low pH and/or exposure to light. A solvent extraction procedure was developed for analysis of the marker compounds from solid samples. Analytes were detected at low parts per million, with an average recovery of 75%. No St. John's wort components were found in the 2 solid functional food samples analyzed.
KW - analytical methods
KW - beverages
KW - chemical composition
KW - food supplements
KW - functional foods
KW - liquid chromatography
KW - mass spectrometry
KW - medicinal plants
KW - tea
KW - Camellia sinensis
KW - Hypericum perforatum
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Hypericum
KW - Clusiaceae
KW - adhyperforin
KW - analytical techniques
KW - drinks
KW - drug plants
KW - hyperforin
KW - hypericin
KW - medicinal herbs
KW - officinal plants
KW - pseudohypericin
KW - St. John's wort
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043172965&site=ehost-live&scope=site
UR - email: Ldejager@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Alternative anaerobic enrichments to the Bacteriological Analytical Manual culture method for isolation of Shigella sonnei from selected types of fresh produce.
AU - Jacobson, A. P.
AU - Thunberg, R. L.
AU - Johnson, M. L.
AU - Hammack, T. S.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 5
SP - 1115
EP - 1122
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Jacobson, A. P.: U.S. Food and Drug Administration, Division of Microbiological Studies, HFS-516, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20043172973. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7782-44-7. Subject Subsets: Human Nutrition; Public Health
N2 - Alternative methods of reducing oxygen during anaerobic enrichment in the Bacteriological Analytical Manual (BAM) Shigella culture method were evaluated and compared to the current and less practical GasPak® method. The alternative anaerobic methods included the use of reducing agents in Shigella broth and reducing culture container headspace volume to minimize atmospheric effects on oxygen concentration in Shigella broth during enrichment. The reducing agents evaluated were sodium thioglycollate, L-cystine, L-cysteine, titanium(III) citrate, and dithiothreitol, each at concentrations of 0.1, 0.5, and 0.01%. The use of Oxyrase for Broth® with the enrichment medium (Shigella broth) was evaluated at concentrations of 10, 20 and 30 µL/mL. Recoveries of chill- and freeze-stressed S. sonnei strains 357 and 20143 were determined with each anaerobic method, including the GasPak method, using inoculation levels ranging from 100 to 103 cells. For each anaerobic method, strain, inoculation level, and stress type, 5 replicate enrichments were evaluated by streaking to MacConkey agar for isolation. The numbers of cultures with each method from which S. sonnei was isolated were used to compare the alternative anaerobic methods to the GasPak method. The alternative anaerobic method with which chill- and freeze-stressed S. sonnei strains 357 and 20143 were isolated most consistently was the use of Oxyrase for Broth in Shigella broth at a concentration of 20 µL/mL. This method was compared to the GasPak anaerobic method in evaluations on the recovery of S. sonnei strains 357 and 20143 from artificially contaminated test portions of parsley, cilantro, green onions, strawberries, carrots, and celery. A third anaerobic method included the use of 0.5 cm mineral oil overlay on cultures containing Oxyrase for Broth at concentrations of 20 µL/mL. Recovery rates of strain 357 were significantly greater (p<0.05) with the GasPak method than with Oxyrase for Broth, with and without the 0.5 cm mineral oil overlay, for test portions of parsley, cilantro, and celery. When Oxyrase for Broth was used with Shigella broth, strain 357 was isolated at higher rates from all produce types, except cilantro, when 0.5 cm mineral oil overlay was applied to enrichment cultures. The use of mineral oil overlay with Oxyrase for Broth also improved recovery of strain 20143 from test portions of all produce types except green onion and strawberries. These differences were significant (p<0.05) with parsley, carrots, and cilantro (1 of 2 evaluations). No statistically significant differences (p>0.05) between the GasPak and Oxyrase for Broth anaerobic methods occurred when mineral oil overlay was used with Oxyrase for Broth. The use of Oxyrase for Broth with a 0.5 cm mineral oil overlay is a practical alternative for anaerobic enrichment with the BAM method in the analysis of some produce types. Differences in recovery among the different produce types and methods occurred between S. sonnei strains 357 and 20143, emphasizing the need for additional S. sonnei strains in future evaluations.
KW - anaerobic conditions
KW - culture media
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - methodology
KW - microbial contamination
KW - oxygen
KW - Shigella sonnei
KW - Shigella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043172973&site=ehost-live&scope=site
UR - email: andrew.jacobson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An interlaboratory-verified method for the determination of vitamins A and E in milk- and soy-based infant formula by liquid chromatography with matrix solid-phase dispersion extraction.
AU - Chase, G. W., Jr.
AU - Ye, L.
AU - Stoakes, V. C.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 5
SP - 1173
EP - 1178
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30602, USA.
N1 - Accession Number: 20043172980. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Dairy Science; Soyabeans
N2 - An interlaboratory-verified, liquid chromatographic (LC) method is presented for determination of all-racemic α-tocopheryl acetate and retinyl palmitate in infant formula. The extraction procedure uses matrix solid-phase dispersion. A sample is mixed with C18, and the mixture is packed into a reservoir and eluted with selective solvents to extract the analytes. After evaporation and filtration, the sample extract is injected directly into a normal-phase LC system with fluorescence detection. All-racemic α-tocopheryl acetate and retinyl palmitate are quantitated isocratically with a mobile phase of hexane containing isopropanol at 0.2% (v/v) and 0.125% (v/v), respectively. A nonfortified zero control reference material (ZRM) was spiked at 5 levels, with 5 replicate analyses of 1/2x, x, 2x, 4x, and 16x where "x" represents the minimum levels of 250 IU/100 kcal (vitamin A) and 0.7 IU/100 kcal (vitamin E) as specified in Title 21 of the Code of Federal Regulations, part 107.100. Recoveries of retinyl palmitate ranged from 83.8 to 107%, and those of all-racemic α-tocopheryl acetate ranged from 87.7 to 108%. Two additional laboratories analyzed the ZRM samples at 4 spiking levels with 6 replicates. Recoveries of retinyl palmitate and all-racemic α-tocopheryl acetate ranged from 92.2 to 104% and from 91.7 to 101%, respectively, in the second laboratory. Recoveries of retinyl palmitate and all-racemic α-tocopheryl acetate ranged from 85.3 to 97.0% and from 86.6 to 110%, respectively, in the third laboratory. Relative standard deviations for all 3 laboratories ranged from 0.2 to 7.5% with an average of 2.9%. In addition, each laboratory analyzed a commercial milk- and commercial soy-based infant formula. Excellent agreement in results was obtained between the 3 laboratories for vitamins A and E in all matrixes.
KW - analytical methods
KW - determination
KW - infant formulae
KW - liquid chromatography
KW - methodology
KW - milk
KW - retinol
KW - retinyl palmitate
KW - soya milk
KW - vitamin E
KW - vitamin E acetate
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - infant formula
KW - infant formulas
KW - methods
KW - retinol palmitate
KW - soy milk
KW - soyabean milk
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043172980&site=ehost-live&scope=site
UR - email: William.chase@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A multiresidue pesticide monitoring procedure using gas chromatography/mass spectrometry and selected ion monitoring for the determination of pesticides containing nitrogen, sulfur, and/or oxygen in fruits and vegetables.
AU - Mercer, G. E.
AU - Hurlbut, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 5
SP - 1224
EP - 1236
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mercer, G. E.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20043172986. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Postharvest Research; Agricultural Entomology
N2 - A procedure for the analysis of over 100 pesticides that only contain combinations of carbon, hydrogen, nitrogen, sulfur, and oxygen (i.e., no phosphorous or halogen atoms) has been developed. The procedure employs gas chromatography with a mass selective detector (GC/MSD), electron impact ionization, and selected ion monitoring. This GC/MSD procedure provided lower limits of quantitation and increased confirmational data compared to the traditional element-selective GC procedures that are commonly used for the detection of this "class" of pesticides. These analytical improvements were demonstrated by 26 pesticides that were detected at ng/g levels in a variety of fruit and vegetable matrixes using this procedure; these pesticides were missed by the traditional element-selective GC procedures. Validation of the procedure was performed using acetone extraction with solid-phase extraction cleanup. Twenty representative target pesticides were used to demonstrate repeatability and linearity of the chromatographic response and recovery from fruit and vegetable matrixes.
KW - fruits
KW - gas chromatography
KW - ionization
KW - methodology
KW - pesticide residues
KW - pesticides
KW - vegetables
KW - methods
KW - vegetable crops
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043172986&site=ehost-live&scope=site
UR - email: gmercer@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extension of AOAC Official Method 999.14 (choline in infant formula and milk) to the determination of choline in dietary supplements.
AU - Rader, J. I.
AU - Weaver, C. M.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1297
EP - 1304
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Rader, J. I.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20053000074. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 50-81-7, 62-49-7. Subject Subsets: Dairy Science
N2 - AOAC Official Method 999.14 is applicable for the determination of choline in milk and infant formulas. To date, its use has not been extended beyond these matrixes. We modified Official Method 999.14 and applied it to the determination of choline in a range of choline-containing dietary supplements. Dietary supplement tablets, capsules, wafers, softgels, liquid products, and drink powders were included. We found that the standard curve could be extended to cover a wider range of choline concentrations and defined a procedure for the use of Norit for samples in which the vitamin C content was high enough to interfere with the analysis. Recoveries of choline added to infant formula powders and to representative dietary supplement tablets, capsules, powdered drink mix, and wafer products were 85-114%. The use of Norit during the procedure did not affect the recovery of choline added to infant formula powders or to dietary supplements. An alkaline digestion was included for use with a product containing lecithin as the sole source of choline. Ten of 11 dietary supplement products analyzed by the modified method contained amounts of choline at or above declarations found on the product labels. The remaining product contained about 40% of the label-declared amount of choline.
KW - ascorbic acid
KW - choline
KW - diets
KW - digestion
KW - food supplements
KW - infant formulae
KW - milk
KW - phosphatidylcholines
KW - infant formula
KW - infant formulas
KW - lecithins
KW - vitamin C
KW - Milk and Dairy Produce (QQ010)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000074&site=ehost-live&scope=site
UR - email: Jeanne.Rader@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interlaboratory verified liquid chromatographic method for analysis of vitamins A and E in soy-based infant formula powder.
AU - Chase, G. W., Jr.
AU - Ye, L.
AU - Stoakes, V. C.
AU - Eitenmiller, R. R.
AU - Long, A. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1329
EP - 1333
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Chase, G. W., Jr.: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309, USA.
N1 - Accession Number: 20053000075. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 110-54-3, 67-63-0, 68-26-8, 79-81-2, 1406-18-4, 58-95-7. Subject Subsets: Human Nutrition; Dairy Science; Soyabeans
N2 - An interlaboratory verified, liquid chromatographic (LC) method is presented for the analysis of all-rac-α-tocopheryl acetate and retinyl palmitate in soy-based infant formula. The extraction procedure uses sample dehydration with magnesium sulfate followed by extraction with isopropanol, hexane-ethyl acetate (85+15, v/v). After evaporation and filtration, the sample extract is injected directly onto a normal-phase LC system with fluorescence detection. All-rac-α-tocopheryl acetate and retinyl palmitate are quantitated isocratically with a mobile phase of hexane containing 0.50% (v/v) and 0.125% (v/v) isopropanol, respectively. A zero control reference material (ZRM) was spiked at 5 levels, with 5 replicate analyses of 1/2x, x, 2x, 4x, and 16x where "x" is the minimum level of 250 IU/100 kcal (vitamin A) and 0.7 IU/100 kcal (vitamin E) as specified in 21 Code of Federal Regulations 107.100. The following recoveries and RSD values represent an average (n=25) of the 5 levels for each analyte: all-rac-α-tocopheryl acetate, 100% (RSD=3.5%); retinyl palmitate, 97.2% (RSD=2.1%). Two additional laboratories analyzed the fortified ZRM samples. Average recoveries (n=24) of all-rac-α-tocopheryl acetate and retinyl palmitate at 4 levels were all-rac-α-tocopheryl acetate, 99.0% (RSD=4.0%), and retinyl palmitate, 96.2% (RSD=1.4%) at the second laboratory. Average recoveries (n=24) of all-rac-α-tocopheryl acetate and retinyl palmitate at 4 levels were all-rac-α-tocopheryl acetate, 102% (RSD=1.4%) and retinyl palmitate, 95.7% (RSD=2.0%) at the third laboratory. In addition, 6 replicates of the same commercial soy-based infant formula powder were run by the 3 laboratories.
KW - analytical methods
KW - hexane
KW - infant formulae
KW - isopropyl alcohol
KW - liquid chromatography
KW - retinol
KW - retinyl palmitate
KW - soyabeans
KW - vitamin E
KW - vitamin E acetate
KW - Glycine (Fabaceae)
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - 2-propanol
KW - alpha-tocopheryl acetate
KW - analytical techniques
KW - axerophthol
KW - infant formula
KW - infant formulas
KW - isopropanol
KW - retinol palmitate
KW - soybeans
KW - tocopheryl acetate
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000075&site=ehost-live&scope=site
UR - email: wchase@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioinformatics and food allergens.
AU - Gendel, S. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1417
EP - 1422
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Gendel, S. M.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Rd, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20053000084. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - Bioinformatics can play an important role in developing improved technology for the detection and characterization of food allergens. However, the full realization of this potential will depend on the development of allergen-specific databases as well as improved methods for data mining within these databases. Examples of existing allergen databases and analysis tools are described, as are the most important issues that need to be addressed in the next stage of database development.
KW - allergens
KW - bioinformatics
KW - databases
KW - detection
KW - foods
KW - data banks
KW - Information and Documentation (CC300)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000084&site=ehost-live&scope=site
UR - email: sgendel@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential allergenicity of novel proteins in murine models.
AU - Westphal, C. D.
AU - Raybourne, R. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1433
EP - 1440
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Westphal, C. D.: U.S. Food and Drug Administration, Center of Food Safety and Applied Nutrition, 8301 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 20053000086. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - Bioengineered crops represent an important advancement for farmers who want to avoid losses caused by insect infestations or adverse environmental conditions. However, the use of modern biotechnology has raised questions regarding the safety of bioengineered foods because of the potential allergenicity of proteins expressed by the newly introduced genes. Standard approaches for safety assessment of these foods are still evolving. Animal models have been suggested as a tool that could help evaluate the potential allergenicity of such compounds. Several investigators are developing animal models to evaluate novel proteins, but none of these have yet been validated. This article reviews the published murine models, rat and mouse in particular, and the different methods used to evaluate parameters related to allergy. It also addresses the factors involved in the development of a model. Finally, it raises some questions that should be considered by the international community so that financial and intellectual efforts can be addressed in a unified manner.
KW - allergens
KW - animal models
KW - biotechnology
KW - food allergies
KW - food safety
KW - genes
KW - human diseases
KW - laboratory animals
KW - proteins
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - allergenicity
KW - food hypersensitivity
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Biotechnology (General) (WW000) (Revised June 2002) [Formerly Biotechnology]
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000086&site=ehost-live&scope=site
UR - email: carmen.westphal@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of extraction buffers using the current approach of detecting multiple allergenic and nonallergenic proteins in food.
AU - Westphal, C. D.
AU - Pereira, M. R.
AU - Raybourne, R. B.
AU - Williams, K. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1458
EP - 1465
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Westphal, C. D.: U.S. Food and Drug Administration, Center for Food and Safety and Applied Nutrition, 8301 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 20053000089. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Human Nutrition
N2 - The detection of food allergens has been a challenge because of the increasing need to ensure the absence of undeclared allergens in foods. The current trend in the detection of some food allergens, like peanuts, is based on the detection of multiple allergenic and nonallergenic proteins, and this is the approach that kit manufacturers have adopted. Because commercial kits differ in their ability to detect allergens, regulatory agencies, the food industry, and kit manufacturers are working together to standardize the detection methods. Three kits for the detection of peanuts have been evaluated for performance by the AOAC Research Institute. For this evaluation, a peanut butter suspension was used as a reference material. Several kit components contribute to between-kit analytical variation, even when the same sample is used. One component of commercial kits, which may be contributing to this variability, is the sample extraction buffer. In this study, differences in extractability of 3 allergenic foods were evaluated by using 4 different extraction buffers. The conclusion is that optimum allergen extractability was buffer-dependent, and no single buffer is appropriate for use as a universal extraction solution for all allergenic foods. Therefore, a thorough evaluation of sample preparation buffers needs to be performed for every individual allergenic food. In light of the results obtained, the current approach used for detection of peanut allergens based on the detection of multiple allergenic and nonallergenic proteins is being analyzed.
KW - allergens
KW - buffers
KW - detection
KW - extraction
KW - foods
KW - groundnut butter
KW - groundnuts
KW - proteins
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - peanut butter
KW - peanuts
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000089&site=ehost-live&scope=site
UR - email: carmen.westphal@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of egg proteins in snack food and noodles.
AU - Williams, K. M.
AU - Westphal, C. D.
AU - Shriver-Lake, L. C.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004///
VL - 87
IS - 6
SP - 1485
EP - 1491
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Williams, K. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053000093. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 54-64-8. Subject Subsets: Human Nutrition; Public Health
N2 - Egg is one of the 5 major allergenic foods that are responsible for more than 3/4 of food allergies in children. Food-allergic responses can be controlled by avoidance of the offending foods. The applicability of a commercial enzyme-linked immunosorbent assay (ELISA) kit for the detection of egg in food products such as cookies, crackers, pretzels, salad dressings, and raw and cooked noodles was evaluated. A preliminary evaluation of an antibody-based biosensor was also performed. A National Institute of Standards and Technology (NIST) whole dried egg powder reference material, SRM 8415, was used as a standard. A homogeneous and stable aqueous egg suspension was prepared for the evaluation of the performance of the Veratox for Egg Allergen Test (Neogen Corp., Lansing, MI). This test does not detect egg yolk proteins. Each gram of the aqueous dried egg suspension contained 643 µg whole dried egg, 0.5 mg thimerosal, and 2.5 mg bovine serum albumin. When cookies, crackers, salad dressings, noodles, and ice cream were spiked at a level of 24 mg/kg SRM 8415, recoveries for whole egg averaged about 28%. All foods containing egg as indicated on the ingredient label were found positive by the Veratox test. No false positives occurred in samples that did not contain eggs. Similar results were obtained using the Naval Research Laboratory (NRL) array biosensor, an evanescent wave fluoroimmunosensor. Results for cooked noodles showed that they contained <1% of the egg found in uncooked noodles. A comparison of extracts from cooked and uncooked noodles by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) revealed differences in protein profiles. The boiling of the noodles could have reduced the immunoreactivity of the egg proteins to the antibodies used in the kit or rendered the egg proteins nonextractable.
KW - allergens
KW - analytical methods
KW - antibodies
KW - biosensors
KW - bovine serum albumin
KW - children
KW - detection
KW - dried egg
KW - egg protein
KW - egg yolk
KW - eggs
KW - ELISA
KW - food allergies
KW - foods
KW - human diseases
KW - noodles
KW - SDS-PAGE
KW - snacks
KW - thiomersal
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - arrays
KW - enzyme linked immunosorbent assay
KW - food hypersensitivity
KW - merthiolate
KW - sodium dodecyl sulfate-PAGE
KW - sodium ethylmercurithiosalicylate
KW - thimerosal
KW - yolk
KW - Eggs and Egg Products (QQ040)
KW - Food Composition and Quality (QQ500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000093&site=ehost-live&scope=site
UR - email: kwillia2@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Declining incidence of chickenpox in the absence of universal childhood immunisation.
AU - Lowe, G. L.
AU - Salmon, R. L.
AU - Thomas, D. R.
AU - Evans, M. R.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2004///
VL - 89
IS - 10
SP - 966
EP - 969
CY - London; UK
PB - BMJ Publishing Group
SN - 0003-9888
AD - Lowe, G. L.: National Public Health Service Communicable Disease Surveillance Centre, Abton House, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20043171072. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - Objective: To examine the epidemiology of chickenpox in Wales from 1986 to 2001. Design: Descriptive analysis of chickenpox consultations reported by the Welsh general practice sentinel surveillance scheme for infectious diseases, compared with annual shingles consultation rates from the same scheme to exclude reporting fatigue and data from a general practice morbidity database to validate results. Setting: A total of 226 884 patients registered with one of 30 volunteer general practices participating in the sentinel surveillance scheme. Main outcome measures: Age standardised and age specific incidence of chickenpox. Results: Crude and age standardised consultation rates for chickenpox declined from 1986 to 2001, with loss of epidemic cycling. Rates remained stable in 0-4 year olds but declined in all older age groups, particularly those aged 5-14 years. Shingles consultation rates remained constant over the same period. Data from the morbidity database displayed similar trends. Conclusion: General practitioner consultation rates for chickenpox are declining in Wales except in pre-school children. These findings are unlikely to be a reporting artefact but may be explained either by an overall decline in transmission or increased social mixing in those under 5 years old, through formal child care and earlier school entry, and associated increasing rates of mild or subclinical infection in this age group. Further investigation, particularly by serological surveillance, is necessary before universal varicella immunisation can be considered in the UK.
KW - children
KW - disease incidence
KW - epidemiology
KW - health protection
KW - herpes zoster
KW - human diseases
KW - immunization
KW - preschool children
KW - serological surveys
KW - shingles
KW - vaccination
KW - vaccines
KW - varicella
KW - Wales
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - chicken pox
KW - immune sensitization
KW - seroepidemiology
KW - varicella-zoster virus
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043171072&site=ehost-live&scope=site
UR - email: Gwen.lowe@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Cryptosporidium antibodies in sera and oral fluids using multiplex bead assay.
AU - Moss, D. M.
AU - Montgomery, J. M.
AU - Newland, S. V.
AU - Priest, J. W.
AU - Lammie, P. J.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2004///
VL - 90
IS - 2
SP - 397
EP - 404
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Moss, D. M.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20043085073. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health; Protozoology
N2 - For the first time, a multiplex bead assay (MBA) was used to assay oral fluid and serum specimens for IgG antibodies to specific Cryptosporidium parvum antigens that were coupled to polystyrene beads. Recombinant C. parvum 17- and 27-kDa antigens (r17 and r27, respectively) both linked with glutathione-S-transferase (GST) fusion proteins, native 17-kDa antigen, and GST alone were each coupled to microspheres that could be differentiated based on variable amounts of internally incorporated red fluorescent dye. Initial and follow-up serum and oral fluid specimens from 62 individuals involved in a 1997 food-related cryptosporidiosis outbreak in Spokane, Washington, USA, were incubated with the coupled beads. Antibodies bound to the coupled beads were detected using biotinylated monoclonal anti-human IgG antibody and streptavidin-labelled r-phycoerythrin. Fluorescence intensity was measured by flow cytometry. For the 3 C. parvum antigens, the median of the mean fluorescence intensity (MFI) was significantly higher (P<0.03) in the initial specimens than in the follow-up specimens. No significant change in IgG responses to GST in oral fluids or serum specimens was observed. For all Cryptosporidium antigens, the MFI in the initial serum specimens correlated with the MFI in the initial oral fluid specimens (P<0.001, r>0.673). For the recombinant antigens used in the MBA, the MFI correlated with the response as measured by an enzyme-linked immunosorbent assay that used r17 and r27 expressed without the GST fusion partner (P<0.001, r>0.854). MBA using sera or more conveniently collected oral fluids, especially from children, may be an option for immunodiagnosis of C. parvum infection and for prospective epidemiological studies designed to monitor infection risk.
KW - antigens
KW - blood serum
KW - cryptosporidiosis
KW - detection
KW - diagnostic techniques
KW - food poisoning
KW - human diseases
KW - IgG
KW - immunodiagnosis
KW - immunological techniques
KW - outbreaks
KW - recombinant antigens
KW - saliva
KW - USA
KW - Washington
KW - Cryptosporidium parvum
KW - man
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - antigenicity
KW - immunogens
KW - multiplex bead assay
KW - salivary secretions
KW - serological diagnosis
KW - serological techniques
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043085073&site=ehost-live&scope=site
UR - email: dmm3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rio Meta strain of Plasmodium vivax in New World monkeys and anopheline mosquitoes.
AU - Collins, W. E.
AU - Sullivan, J. A. S.
AU - Galland, G. G.
AU - Barnwell, J. W.
AU - Nace, D.
AU - Williams, A.
AU - Williams, T.
AU - Bounngaseng, A.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2004///
VL - 90
IS - 4
SP - 685
EP - 688
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20043168426. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - An archived strain of Plasmodium vivax, isolated from Rio Meta, northern Colombia, in 1972 was adapted to grow in splenectomized Aotus lemurinus griseimembra and A. nancymai monkeys. Anopheles freeborni, An. maculatus, An. dirus, An. culicifacies, and An. albimanus were shown to be susceptible to infection by feeding on infected monkeys. Infections were more readily obtained by feeding on A. l. griseimembra than on A. nancymai. Transmission through sporozoites was obtained in an A. l. griseimembra monkey after a prepatent period of 24 days.
KW - disease transmission
KW - infections
KW - sporozoites
KW - strains
KW - Colombia
KW - Anopheles
KW - Anopheles albimanus
KW - Anopheles culicifacies
KW - Anopheles dirus
KW - Anopheles freeborni
KW - Anopheles maculatus
KW - Aotus
KW - Aotus lemurinus
KW - Aotus nancymai
KW - Culicidae
KW - monkeys
KW - Plasmodium vivax
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Anopheles
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Aotus
KW - Andean Group
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Aotus lemurinus griseimembra
KW - mosquitoes
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043168426&site=ehost-live&scope=site
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and characterization of Clostridium perfringens using single target DNA microarray chip.
AU - Al-Khaldi, S. F.
AU - Villanueva, D.
AU - Chizhikov, V.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2004///
VL - 91
IS - 3
SP - 289
EP - 296
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Al-Khaldi, S. F.: HFS-517, Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA.
N1 - Accession Number: 20043039178. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - A DNA microarray method was developed to identify the presence of toxin genes: encoding beta toxin (cpb), epsilon toxin (etx), enterotoxin (cpe), alpha toxin (cpa), and iota toxin (iA) in Clostridium perfringens. To build the DNA chip, each gene sequence was represented by one ~22-bp amino-modified oligonucleotide printed twice on aldehyde-coated slides. Multiplex PCR with Cy3 and Cy5-dCTP derivatized fluorescent nucleotides was used to label five genes and fluorescent probes were prepared. The PCR probes were denatured and single-strand-labeled DNAs were separated and purified using magnetic beads. The presence of toxin genes in C. perfringens was detected by hybridization of amplified ssDNA probes to oligonucleotides on the chip representing one target sequence of each toxin gene. The DNA chip was able to identify eight strains of C. perfringens.
KW - bacterial toxins
KW - characterization
KW - DNA
KW - microbiological techniques
KW - nucleotide sequences
KW - polymerase chain reaction
KW - toxins
KW - Clostridium perfringens
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - deoxyribonucleic acid
KW - DNA sequences
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043039178&site=ehost-live&scope=site
UR - email: Sufian.Al-Khaldi@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinical use of immunoassays in assessing exposure to fungi and potential health effects related to fungal exposure.
AU - Trout, D. B.
AU - Seltzer, J. M.
AU - Page, E. H.
AU - Biagini, R. E.
AU - Schmechel, D.
AU - Lewis, D. M.
AU - Boudreau, A. Y.
JO - Annals of Allergy, Asthma, & Immunology
JF - Annals of Allergy, Asthma, & Immunology
Y1 - 2004///
VL - 92
IS - 5
SP - 483
EP - 492
CY - Arlington Heights; USA
PB - American College of Allergy, Asthma, & Immunology
SN - 1081-1206
AD - Trout, D. B.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy, MS R-10, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20043122078. Publication Type: Journal Article. Language: English. Number of References: 76 ref. Registry Number: 37341-29-0, 308067-58-5. Subject Subsets: Weeds; Public Health; Medical & Veterinary Mycology
N2 - Objective: To review and summarize current evidence regarding the role of immunoassays in clinical assessments of exposure to fungi and health effects related to fungal exposure. Data Sources: We reviewed relevant scientific investigations and previously published reviews. Study Selection: The authors' clinical, laboratory and public health experiences were used to evaluate relevant data for scientific merit. Results: Testing to determine the presence of IgE to specific fungi may be a useful component of a complete clinical evaluation in the diagnosis of illnesses that can be caused by immediate hypersensitivity such as allergic rhinitis and asthma. Detection of IgG to specific fungi has been used as a marker of exposure to agents that may cause illnesses such as hypersensitivity pneumonitis. However, the ubiquitous nature of many fungi and the lack of specificity of fungal antigens limit the usefulness of these types of tests in the evaluation of potential building-related illness and fungal exposure. Specific serological tests (such as tests for cryptococcal antigen, coccidioidal antibody and Histoplasma antigen) have been shown to be useful in the diagnosis of some fungal infections, but these are the exception not the rule. Conclusions: There is currently not enough scientific evidence to support the routine clinical use of immunoassays as a primary means of assessing environmental fungal exposure or health effects related to fungal exposure. Health care providers who care for persons expressing concerns about the relationship of symptoms to potential exposure to fungi are advised to use immunoassay results with care and only as an adjunct to a comprehensive approach to patient care.
KW - allergies
KW - asthma
KW - diagnostic techniques
KW - fungal antigens
KW - human diseases
KW - hypersensitivity
KW - IgE
KW - IgG
KW - immediate hypersensitivity
KW - immunoassay
KW - immunodiagnosis
KW - mycoses
KW - pneumonitis
KW - reviews
KW - rhinitis
KW - Coccidioides
KW - Cryptococcus (Fungi)
KW - fungi
KW - Histoplasma
KW - man
KW - Onygenaceae
KW - Onygenales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Cryptococcus (Fungi)
KW - Tremellaceae
KW - Tremellales
KW - Tremellomycetes
KW - Agaricomycotina
KW - Basidiomycota
KW - Ajellomycetaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - allergic responses
KW - Cryptococcus (Deuteromycotina)
KW - fungus
KW - hypersensitiveness
KW - reagin
KW - reaginic antibodies
KW - serological diagnosis
KW - Weeds and Noxious Plants (FF500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043122078&site=ehost-live&scope=site
UR - email: dtrout@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the prevalence of antiwheat-, anti-flour dust, and anti-α-amylase specific IgE antibodies in US blood donors.
AU - Biagini, R. E.
AU - MacKenzie, B. A.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - Striley, C. A. F.
AU - Robertson, S. K.
AU - Snawder, J. E.
JO - Annals of Allergy, Asthma, & Immunology
JF - Annals of Allergy, Asthma, & Immunology
Y1 - 2004///
VL - 92
IS - 6
SP - 649
EP - 653
CY - Arlington Heights; USA
PB - American College of Allergy, Asthma, & Immunology
SN - 1081-1206
AD - Biagini, R. E.: Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, MS C-26, Robert A. Taft Laboratories, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043142889. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9000-90-2, 37341-29-0. Subject Subsets: Wheat, Barley & Triticale Abstracts; Public Health; Human Nutrition
N2 - Background: Asthma in bakery workers is one of the most frequently occurring forms of occupational asthma in the world. Experience from other countries has shown the prevalence of sensitization (IgE) to bakery-associated allergens (BAAs: wheat, W; flour dust, FD; α-amylase, AA) in bakery workers to be 5% to 53%, whereas the prevalence in nonoccupationally exposed individuals was estimated to be 1.2% to 6.4%. Objective: To estimate the prevalence of BAA sensitization by measuring BAA specific IgE in the residual serum tubes of volunteer blood donors. Methods: Serum samples from 534 volunteer blood donors were measured for anti-W, anti-FD, and anti-AA specific IgE antibodies (in duplicate) using the AlaSTAT microplate assay. Samples with BAA IgE concentrations of 0.35 kU/litre or greater were considered positive. Results: Nineteen of 530 serum samples (3.6%; 95% confidence interval, CI; 3.3%-3.9%) were positive for W (range, 0.38-3.61 kU/litre), whereas 31 of 534 (5.8%; 95% CI, 5.3%-6.3%) were positive for FD (range, 0.35-2.34 kU/litre) and 5 of 529 (1.0%; 95% CI, 0.9%-1.1%) were positive for AA (range, 0.38-1.59 kU/litre). Thirteen serum samples were positive for both W and FD; one sample each was positive for W and AA and FD and AA. Conclusions: The prevalence of IgE sensitization in serum samples from a relatively large unselected population of volunteer blood donors is 1.0% for AA, 3.6% for W, and 5.8% for FD, which agrees well with data from other countries for sensitization prevalence rates for nonoccupationally exposed individuals.
KW - allergens
KW - allergies
KW - alpha-amylase
KW - antibodies
KW - asthma
KW - bakers
KW - epidemiology
KW - human diseases
KW - IgE
KW - occupational hazards
KW - seroprevalence
KW - wheat
KW - USA
KW - man
KW - Triticum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - reagin
KW - reaginic antibodies
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043142889&site=ehost-live&scope=site
UR - email: rbiagini@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative contamination and transfer of Escherichia coli from foods by houseflies, Musca domestica L. (Diptera: Muscidae).
AU - Jesús, A. J. de
AU - Olsen, A. R.
AU - Bryce, J. R.
AU - Whiting, R. C.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2004///
VL - 93
IS - 2
SP - 259
EP - 262
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0168-1605
AD - Jesús, A. J. de: U.S. Food and Drug Administration/Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20043098580. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The housefly, Musca domestica L. (Diptera: Muscidae), is recognized as an important factor in the dissemination of various infectious diseases such as cholera, shigellosis, and salmonellosis. They can also serve as a cross-contamination vector for other foodborne pathogens. However, the potential for bacterial transfer by houseflies has been demonstrated in a qualitative rather than quantitative manner. In this study, the numbers of bacteria a housefly can carry on its body and transfer to a clean surface after exposure to a sugar-milk aqueous solution, steak, and potato salad contaminated with a fluorescent gene Escherichia coli (8 log10 CFU/ml) were determined. In the first series of experiments to quantify bacterial numbers on the flies, about 40-60 flies were transferred into a sterile cage, exposed to the food for 30 min, the flies immobilized and the attached E. coli on each fly enumerated. Detectable E. coli (>1.7 log10 CFU/fly) were found on 43% (29/67), 53% (23/43), and 62% (32/52) of the flies in the cages with sugar/milk, steak, and potato salad, respectively. For the positive flies, the geometric mean carriage (log10 CFU/fly) was 2.93±1.24 for sugar-milk, 3.77±1.28 for steak, and 2.25±0.64 for the potato salad. In the second series of experiments, the transfer of bacteria by individual flies from contaminated food to the inner surface of a sterile jar per each landing was determined. E. coli transferred from the sugar-milk was 3.5±0.7 log10 CFU/fly-landing, 3.9±0.7 for steak and 2.61±1.16 for the potato salad. From the initial contamination levels of bacteria and the number of transferred bacteria, it can be calculated that flies contaminate clean surfaces with approximately 0.1 mg of food per landing.
KW - bacterial diseases
KW - disease transmission
KW - vectorial capacity
KW - Diptera
KW - Escherichia coli
KW - Musca domestica
KW - Muscidae
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Musca
KW - Muscidae
KW - Diptera
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - house fly
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043098580&site=ehost-live&scope=site
UR - email: adejesus@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vaccine risk perception among reporters of autism after vaccination: vaccine adverse event reporting system 1990-2001.
AU - Woo, E. J.
AU - Ball, R.
AU - Bostrom, A.
AU - Shadomy, S. V.
AU - Ball, L. K.
AU - Evans, G.
AU - Braun, M.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004///
VL - 94
IS - 6
SP - 990
EP - 995
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Woo, E. J.: Vaccine Safety Branch, Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20043107010. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Objectives: We investigated vaccine risk perception among reporters of autism to the Vaccine Adverse Event Reporting System (VAERS) [USA]. Methods: We conducted structured interviews with 124 parents who reported autism and related disorders to VAERS from 1990 to 2001 and compared results with those of a published survey of parents in the general population. Results: Respondents perceived vaccine-preventable diseases as less serious than did other parents. Only 15% of respondents deemed immunization extremely important for children's health; two-thirds had withheld vaccines from their children. Conclusions: Views of parents who believe vaccines injured their children differ significantly from those of the general population regarding the benefits of immunization. Understanding the factors that shape this perspective can improve communication among vaccine providers, policymakers, and parents/patients.
KW - adverse effects
KW - attitudes
KW - autism
KW - children
KW - immunization
KW - parents
KW - risk
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043107010&site=ehost-live&scope=site
UR - email: wooj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Principles of risk analysis as applied to microbial food safety concerns.
AU - Buchanan, R. L.
JO - Mitteilungen aus Lebensmitteluntersuchung und Hygiene
JF - Mitteilungen aus Lebensmitteluntersuchung und Hygiene
Y1 - 2004///
VL - 95
IS - 1
SP - 6
EP - 12
CY - Bern; Switzerland
PB - Bundesamt für Gesundheit
SN - 1424-1307
AD - Buchanan, R. L.: US DHHS Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20043050105. Publication Type: Journal Article. Language: English. Language of Summary: German; French. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - This paper describes the different steps of a microbiological risk analysis from risk assessment through risk management of food safety. Risk assessment is the process whereby the risk associated with a hazard is evaluated either quantitatively or qualitatively. Risk management is the process whereby information related to a risk, including the results of a risk assessment if available, are used to make decisions on how the risk will be controlled and then how that decision is implemented.
KW - food contamination
KW - food safety
KW - hazards
KW - microbial contamination
KW - reviews
KW - risk
KW - risk analysis
KW - risk assessment
KW - food contaminants
KW - risk management
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043050105&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interactions between schistosomiasis and human immunodeficiency virus in Western Kenya.
AU - Secor, W. E.
AU - Karanja, D. M. S.
AU - Colley, D. G.
A2 - Andrade, Z. A.
JO - Memórias do Instituto Oswaldo Cruz
JF - Memórias do Instituto Oswaldo Cruz
Y1 - 2004///
VL - 99
SP - 93
EP - 95
CY - Rio de Janeiro; Brazil
PB - Instituto Oswaldo Cruz
SN - 0074-0276
AD - Secor, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, Public Health Service, Department of Health and Human Services, CDC, Atlanta, Georgia, USA.
N1 - Accession Number: 20043150837. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Tropical Diseases; Helminthology
N2 - For the past ten years, we have been exploring the relationship between schistosomiasis and human immunodeficiency virus (HIV-1) and how coinfection with both agents may affect the pathology and progression of each infection. To date, given the systems we have examined, the effects of HIV-1 on schistosomiasis have been more profound than the effects of schistosomiasis on HIV-1 progression. Additional key questions with important public health implications remain unanswered, but hopefully not unanswerable.
KW - concurrent infections
KW - HIV-1 infections
KW - human diseases
KW - schistosomiasis
KW - Kenya
KW - Human immunodeficiency virus 1
KW - man
KW - Schistosoma
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - bilharzia
KW - bilharziasis
KW - human immunodeficiency virus type 1
KW - schistosomosis
KW - Strigeida
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043150837&site=ehost-live&scope=site
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.
AU - Markovic, I.
AU - Stantchev, T. S.
AU - Fields, K. H.
AU - Tiffany, L. J.
AU - Tomiç, M.
AU - Weiss, C. D.
AU - Broder, C. C.
AU - Strebel, K.
AU - Clouse, K. A.
JO - Blood
JF - Blood
Y1 - 2004///
VL - 103
IS - 5
SP - 1586
EP - 1594
CY - Washington; USA
PB - American Society of Hematology
SN - 0006-4971
AD - Markovic, I.: Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Bethesda, Maryland, USA.
N1 - Accession Number: 20043048129. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Attachment of gp120 to CD4 during HIV-1 entry triggers structural rearrangement in gp120 that enables binding to an appropriate coreceptor. Following coreceptor engagement, additional conformational changes occur in the envelope (Env), resulting in fusion of virion and cell membranes. Catalysts with redox-isomerase activity, such as protein disulfide isomerase (PDI), facilitate Env conversion from its inactive to its fusion-competent conformation. We report here that anti-PDI agents effectively blocked CXCR4 Env-mediated fusion and spread of virus infection. Exogenously added PDI, in turn, can rescue fusion from this blockade. Also, PDI facilitated thiol/disulfide rearrangement in gp120 during conformational change, whereas inhibition of this redox shuffling prevented gp41 from assuming the fusogenic 6-helix bundle conformation. At the virus-cell contact site, gp120 induced assembly of PDI, CD4, and CXCR4 into a tetramolecular protein complex serving as a portal for viral entry. Our findings support the hypothesis that Env conformational change depends on a well-coordinated action of a tripartite system in which PDI works in concert with the receptor and the coreceptor to effectively lower the activation energy barrier required for Env conformational rearrangement.
KW - biochemical receptors
KW - CD4+ lymphocytes
KW - cell membranes
KW - cytoadherence
KW - envelope protein gp120
KW - immunopathology
KW - molecular conformation
KW - signal transduction
KW - T lymphocytes
KW - thiols
KW - Human immunodeficiency virus 1
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - CD4+ cells
KW - cell adhesion
KW - gp120
KW - human immunodeficiency virus type 1
KW - immunopathogenesis
KW - mercaptans
KW - protein disulfide isomerase
KW - T cells
KW - T4 lymphocytes
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043048129&site=ehost-live&scope=site
UR - email: markovic@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - 2000-2001 food label and package survey: an update on prevalence of nutrition labeling and claims on processed, packaged foods.
AU - LeGault, L.
AU - Brandt, M. B.
AU - McCabe, N.
AU - Adler, C.
AU - Brown, A. M.
AU - Brecher, S.
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2004///
VL - 104
IS - 6
SP - 952
EP - 958
CY - Chicago; USA
PB - American Dietetic Association
SN - 0002-8223
AD - LeGault, L.: Food and Drug Administration, Center for Food Safety and Applied Nutrition (HFS-840), 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063215648. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - The food label is an important tool for improving the public's understanding of the health benefits of following a nutritious diet. The Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA) has continued to study food labels with its Food Label and Package Survey (FLAPS). Data from the 2000-2001 FLAPS characterize various aspects of the labeling of processed, packaged foods, including nutrition labeling and various types of label claims. The FDA used a multistage, representative sample of food products from the Information Resources Inc (IRI) 1999 supermarket database as the basis for the FLAPS sample. The final FLAPS database consists of 1,281 foods. An estimated 98.3% of FDA-regulated processed, packaged foods sold annually have nutrition labels, with an additional 1.7% of products exempt from nutrition labeling requirements. Health claims (4.4%), structure/function claims (6.2%), and nutrient content claims (49.7%) were identified on food labels. In addition to the resource this survey provides to CFSAN in assessing health and nutrition information on the food label, registered dietitians and other health professionals can use FLAPS data to assist consumers in choosing a more nutritious diet to improve their health and well-being.
KW - food packaging
KW - food products
KW - health claims
KW - nutrition labeling
KW - nutritive value
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - nutritional value
KW - quality for nutrition
KW - United States of America
KW - Marketing and Distribution (EE700)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063215648&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B758G-4CGKXB4-S&_user=3891418&_handle=V-WA-A-W-BD-MsSAYWA-UUW-U-AAZCZCVUDU-AAZBWBVYDU-CZWDAEEB-BD-U&_fmt=full&_coverDate=06%2F30%2F2004&_rdoc=22&_orig=browse&_srch=%23toc%2312926%232004%23998959993%23503651!&_cdi=12926&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=b4697215e35a7ce0a2a63b7122d75052
UR - email: llegault@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects.
AU - Lawson, C. C.
AU - Schnorr, T. M.
AU - Whelan, E. A.
AU - Deddens, J. A.
AU - Dankovic, D. A.
AU - Piacitelli, L. A.
AU - Sweeney, M. H.
AU - Connally, L. B.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 14
SP - 1403
EP - 1408
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Lawson, C. C.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-15), Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043179508. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Agricultural Entomology; Weeds; Public Health
N2 - Agent Orange is a phenoxy herbicide that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We studied pregnancy outcomes among wives of male chemical workers who were highly exposed to chemicals contaminated with TCDD and among wives of nonexposed neighbourhood referents. For exposed pregnancies, we estimated serum TCDD concentration at the time of conception using a pharmacokinetic model. The mean TCDD concentration for workers' births was 254 pg/g lipid (range, 3-16 340 pg/g). The mean referent concentration of 6 pg/g was assigned to pregnancies fathered by workers before exposure. A total of 1117 live singleton births of 217 referent wives and 176 worker wives were included. Only full-term births were included in the birth weight analysis (≥37 weeks of gestation). Mean birth weight among full-term babies was similar among referents' babies (n=604), preexposure workers' babies (n=221), and exposed workers' babies (n=292) (3420, 3347, and 3442 g, respectively). Neither continuous nor categorical TCDD concentration had an effect on birth weight for term infants after adjustment for infant sex, mother's education, parity, prenatal cigarette smoking, and gestation length. An analysis to estimate potential direct exposure of the wives during periods of workers' exposure yielded a nonstatistically significant increase in infant birth weight of 130 g in the highest exposure group (TCDD concentration >254 pg/g) compared with referents (P=0.09). Mothers' reports of preterm delivery showed a somewhat protective association with paternal TCDD (log) concentration (odds ratio=0.8; 95% confidence interval, 0.6-1.1). We also include descriptive information on reported birth defects. Because the estimated TCDD concentrations in this population were much higher than in other studies, the results indicate that TCDD is unlikely to increase the risk of low birth weight or preterm delivery through a paternal mechanism.
KW - birth weight
KW - children
KW - congenital abnormalities
KW - contaminants
KW - dioxins
KW - exposure
KW - fathers
KW - herbicides
KW - infants
KW - low birth weight infants
KW - mothers
KW - occupational hazards
KW - pregnancy
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth defects
KW - congenital malformations
KW - gestation
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043179508&site=ehost-live&scope=site
UR - email: CJL9@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using decision forest to classify prostate cancer samples on the basis of SELDI-TOF MS data: assessing chance correlation and prediction confidence.
AU - Tong, W. D.
AU - Xie, Q.
AU - Hong, H. X.
AU - Fang, H.
AU - Shi, L. M.
AU - Perkins, R.
AU - Petricoin, E. F.
T3 - Toxicogenomics.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 16
SP - 1622
EP - 1627
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Tong, W. D.: Center for Toxicoinformatics, Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Rd., HFT020, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043209695. Publication Type: Journal Article. Note: Toxicogenomics. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Class prediction using "omics" data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few samples and a very large number of predictor variables (e.g., genes of DNA microarray data or m/z peaks of mass spectrometry data). These characteristics manifest the importance of assessing potential random correlation and overfitting of noise for a classification model based on omics data. We present a novel classification method, decision forest (DF), for class prediction using omics data. DF combines the results of multiple heterogeneous but comparable decision tree (DT) models to produce a consensus prediction. The method is less prone to overfitting of noise and chance correlation. A DF model was developed to predict presence of prostate cancer using a proteomic data set generated from surface-enhanced laser deposition/ionization time-of-flight mass spectrometry. The degree of chance correlation and prediction confidence of the model was rigorously assessed by extensive cross-validation and randomization testing. Comparison of model prediction with imposed random correlation demonstrated biologic relevance of the model and the reduction of overfitting in DF. Furthermore, two confidence levels (high and low confidences) were assigned to each prediction, where most misclassifications were associated with the low-confidence region. For the high-confidence prediction, the model achieved 99.2% sensitivity and 98.2% specificity. The model also identified a list of significant peaks that could be useful for biomarker identification. DF should be equally applicable to other omics data such as gene expression data or metabolomic data. The DF algorithm is available upon request.
KW - algorithms
KW - biochemical markers
KW - correlation
KW - human diseases
KW - men
KW - neoplasms
KW - prostate
KW - prostate cancer
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biomarkers
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043209695&site=ehost-live&scope=site
UR - email: wtong@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The sources of inflammatory mediators in the lung after silica exposure.
AU - Rao, K. M. K.
AU - Porter, D. W.
AU - Meighan, T.
AU - Castranova, V.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 17
SP - 1679
EP - 1685
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Rao, K. M. K.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Box 2015, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053163147. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 130068-27-8, 7631-86-9, 125978-95-2.
N2 - The expression of 10 genes implicated in the regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in vivo (Sprague-Dawley rats). Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 2 (MIP-2), without a concomitant increase in the protein levels. AMs isolated after intratracheal instillation of silica showed up-regulated mRNA levels of granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-1β, IL-10, and inducible nitric-oxide synthase. IL-6, MCP-1, and MIP-2 protein levels were elevated in bronchoalveolar lavage fluid. Fibroblasts under basal culture conditions express much higher levels of IL-6 and GM-CSF compared with AMs. Coculture of AMs and alveolar type II cells, or coculture of AMs and lung fibroblasts, in contact cultures or Transwell chambers, revealed no synergistic effect. Therefore, such interaction does not explain the effects seen in vivo. Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung.
KW - colony stimulating factor
KW - exposure
KW - fibroblasts
KW - gene expression
KW - genes
KW - inflammation
KW - interleukin 1
KW - interleukin 10
KW - interleukin 6
KW - laboratory animals
KW - lungs
KW - macrophages
KW - messenger RNA
KW - molecular genetics
KW - monocytes
KW - nitric-oxide synthase
KW - silica
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - granulocyte macrophage-colony stimulating factor
KW - macrophage inflammatory protein 2
KW - monocyte chemoattractant protein 1
KW - mRNA
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053163147&site=ehost-live&scope=site
UR - email: mir8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Applying new biotechnologies to the study of occupational cancer - a workshop summary.
AU - Toraason, M.
AU - Albertini, R.
AU - Bayard, S.
AU - Bigbee, W.
AU - Blair, A.
AU - Boffetta, P.
AU - Bonassi, S.
AU - Chanock, S.
AU - Christiani, D.
AU - Eastmond, D.
AU - Hanash, S.
AU - Henry, C.
AU - Kadlubar, F.
AU - Mirer, F.
AU - Nebert, D.
AU - Rapport, S.
AU - Rest, K.
AU - Rothman, N.
AU - Ruder, A.
AU - Savage, R.
AU - Schulte, P.
AU - Siemiatycki, J.
AU - Shields, P.
AU - Smith, M.
AU - Tolbert, P.
AU - Vermeulen, R. (et al)
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 4T
SP - 413
EP - 416
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Toraason, M.: National Institute for Occupational Safety and Health C23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063206009. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health; Agricultural Biotechnology
N2 - As high-throughput technologies in genomics, transcriptomics, and proteomics evolve, questions arise about their use in the assessment of occupational cancers. To address these questions, the National Institute for Occupational Safety and Health, the National Cancer Institute, the National Institute of Environmental Health Sciences, and the American Chemistry Council sponsored a workshop 8-9 May 2002 in Washington, DC. The workshop brought together 80 international specialists whose objective was to identify the means for best exploiting new technologies to enhance methods for laboratory investigation, epidemiologic evaluation, risk assessment, and prevention of occupational cancer. The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk.
KW - biochemical markers
KW - biotechnology
KW - epidemiology
KW - genomics
KW - genotype environment interaction
KW - human diseases
KW - molecular biology
KW - molecular genetics
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - proteomics
KW - risk assessment
KW - toxicogenomics
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - biomarkers
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063206009&site=ehost-live&scope=site
UR - http://www.ehponline.org/txg/docs/2004/6343/abstract.html
UR - email: mtoraason@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dye bias correction in dual-labeled cDNA microarray gene expression measurements.
AU - Rosenzweig, B. A.
AU - Pine, P. S.
AU - Domon, O. E.
AU - Morris, S. M.
AU - Chen, J. J.
AU - Sistare, F. D.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 4T
SP - 480
EP - 487
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Rosenzweig, B. A.: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20063206019. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias. Transcript-dependent dye bias may be due to gene-specific differences of incorporation of two distinctly different chemical dyes and the resultant differential hybridization efficiencies of these two chemically different targets for the same probe. Several approaches were used to assess and minimize the effects of dye bias on fluorescent hybridization signals and maximize the experimental design efficiency of a cell culture experiment. Dye bias was measured at the individual transcript level within each batch of simultaneously processed arrays by replicate dual-labeled split-control sample hybridizations and accounted for a significant component of fluorescent signal differences. This transcript-dependent dye bias alone could introduce unacceptably high numbers of both false-positive and false-negative signals. We found that within a given set of concurrently processed hybridizations, the bias is remarkably consistent and therefore measurable and correctable. The additional microarrays and reagents required for paired technical replicate dye-swap corrections commonly performed to control for dye bias could be costly to end users. Incorporating split-control microarrays within a set of concurrently processed hybridizations to specifically measure dye bias can eliminate the need for technical dye swap replicates and reduce microarray and reagent costs while maintaining experimental accuracy and technical precision. These data support a practical and more efficient experimental design to measure and mathematically correct for dye bias.
KW - complementary DNA
KW - DNA microarrays
KW - dyes
KW - gene expression profiling
KW - genomics
KW - cDNA
KW - dyestuffs
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063206019&site=ehost-live&scope=site
UR - http://www.ehponline.org/realfiles/txg/docs/2004/6694/abstract.html
UR - email: rosenzweigb@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.
AU - Thompson, K. L.
AU - Afshari, C. A.
AU - Amin, R. P.
AU - Bertram, T. A.
AU - Car, B.
AU - Cunningham, M.
AU - Kind, C.
AU - Kramer, J. A.
AU - Lawton, M.
AU - Mirsky, M.
AU - Naciff, J. M.
AU - Oreffo, V.
AU - Pine, P. S.
AU - Sistare, F. D.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004///
VL - 112
IS - 4T
SP - 488
EP - 494
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Thompson, K. L.: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Life Sciences Building 64, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA.
N1 - Accession Number: 20063206020. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Within the International Life Sciences Institute Committee on Genomics, a working group was formed to focus on the application of microarray technology to preclinical assessments of drug-induced nephrotoxicity. As part of this effort, Sprague-Dawley rats were treated with the nephrotoxicant cisplatin at doses of 0.3-5 mg/kg over a 4- to 144-hr time course. RNA prepared from these animals was run on a variety of microarray formats at multiple sites. A set of 93 differentially expressed genes associated with cisplatin-induced renal injury was identified on the National Institute of Environmental Health Sciences (NIEHS) custom cDNA microarray platform using quadruplicate measurements of pooled animal RNA. The reproducibility of this profile of statistically significant gene changes on other platforms, in pooled and individual animal replicate samples, and in an independent study was investigated. A good correlation in response between platforms was found among the 48 genes in the NIEHS data set that could be matched to probes on the Affymetrix RGU34A array by UniGene identifier or sequence alignment. Similar results were obtained with genes that could be linked between the NIEHS and Incyte or PHASE-1 arrays. The degree of renal damage induced by cisplatin in individual animals was commensurate with the number of differentially expressed genes in this data set. These results suggest that gene profiles linked to specific types of tissue injury or mechanisms of toxicity and identified in well-performed replicated microarray experiments may be extrapolatable across platform technologies, laboratories, and in-life studies.
KW - animal models
KW - DNA microarrays
KW - gene expression
KW - gene expression profiling
KW - genomics
KW - kidneys
KW - laboratory animals
KW - nephrotoxicity
KW - toxicology
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cisplatin
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063206020&site=ehost-live&scope=site
UR - http://www.ehponline.org/realfiles/txg/docs/2004/6676/abstract.html
UR - email: Thompsonk@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection.
AU - Gaughan, D. M.
AU - Hughes, M. D.
AU - Oleske, J. M.
AU - Malee, K.
AU - Gore, C. A.
AU - Nachman, S.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004///
VL - 113
IS - 6
SP - e544
EP - e551
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Gaughan, D. M.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
N1 - Accession Number: 20063027894. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Objective. Psychiatric manifestations of pediatric human immunodeficiency virus (HIV) infection have been described. However, data on severe sequelae requiring hospitalization among this population have not been reported. Methods. The Pediatric Acquired Immunodeficiency Syndrome (AIDS) Clinical Trials Group (PACTG) 219C is a prospective cohort study designed to examine long-term outcomes among HIV-infected children and HIV-uninfected infants born to HIV-infected women. Children with HIV infection who have enrolled in PACTG 219C are examined quarterly, with collection of clinical and laboratory data. Hospitalizations and diagnoses for all participants between September 2000 (when enrollment into PACTG 219C was started) and December 2002 were reviewed. Results. Among 1808 HIV-infected participants who were <15 years of age at the last visit date, 25 children had been hospitalized for psychiatric manifestations, 8 before enrollment into PACTG 219C. Seventeen children were hospitalized during 2757 person-years of follow-up monitoring after entry into PACTG 219C, which represents an incidence of 6.17 cases per 1000 person-years (95% confidence interval: 3.59-9.87 cases per 1000 person-years). This was significantly higher than the incidence of 1.70 cases per 1000 person-years (95% confidence interval: 1.67-1.72 cases per 1000 person-years) in the general pediatric population <15 years of age, as reported in the 2000 National Hospital Discharge Survey, yielding a relative rate of 3.62 (95% confidence interval: 2.11-5.80). A total of 32 HIV-infected children, regardless of age, were hospitalized because of psychiatric illnesses. The majority of patients were admitted because of depression (n=16) or behavioral disorders (n=8). Fifteen (47%) underwent multiple psychiatric hospitalizations. The median age at the first psychiatric hospitalization was 11 years (range: 4-17 years); all patients had been perinatally infected. Knowledge of HIV seropositivity status and having experienced a significant life event were both significantly associated with an increased risk of psychiatric hospitalization (hazard ratios of 6.13 and 3.04, respectively). No psychiatric hospitalizations were observed among the 1021 HIV-uninfected members of the cohort. Conclusions. Children with HIV/AIDS are at increased risk for psychiatric hospitalizations during childhood and early adolescence, compared with the general pediatric population. Knowledge of HIV seropositivity status and recent significant life events were significantly associated with increased risks of admission in this population.
KW - acquired immune deficiency syndrome
KW - adolescents
KW - children
KW - clinical aspects
KW - human diseases
KW - Human immunodeficiency viruses
KW - infants
KW - mental disorders
KW - pregnancy
KW - risk assessment
KW - women
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - clinical picture
KW - gestation
KW - mental illness
KW - psychiatric disorders
KW - teenagers
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063027894&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org/cgi/content/abstract/113/6/e544
UR - email: sharon.nachman@stonybrook.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health status and health services utilization among US Chinese, Asian Indian, Filipino, and other Asian/Pacific Islander children.
AU - Yu, S. M.
AU - Huang, Z. J.
AU - Singh, G. K.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004///
VL - 113
IS - 1(2 of 2)
SP - 101
EP - 107
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Yu, S. M.: Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Ln, 18A-55, Rockville, MD 20857, USA.
N1 - Accession Number: 20043033383. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Objective: This study examines the health status and health services access and utilization characteristics of US Chinese, Asian Indian, Filipino, other Asian/Pacific Islander (API), and non-Hispanic white children by using nationally representative data. Methods: We analysed the aggregated data file from the National Health Interview Survey during 1997-2000, including 334 Chinese, 287 Asian Indian, 292 Filipino, 696 "other API," and 29 016 non-Hispanic white children <18 years old. Bivariate and multivariate analyses were conducted to examine the relationship between Asian ethnicities and some dependent variables including components of health status, health services access, and utilization. Results: Logistic regression reveals that all Asian American children were less likely to miss school because of illness or injury or have learning disabilities compared with non-Hispanic whites. Other APIs were less likely to be taking prescription medication for at least 3 months, and Asian Indian children were half as likely to have chronic conditions. Chinese, Filipino, and other API children were more likely to be without contact with a health professional within the past 12 months. Citizenship/nativity status, maternal education attainment, and poverty status were all significant independent risk factors for health care access and utilization. Conclusions: Asian ethnicities and being foreign-born are generally associated with more favourable health status measures such as school absence, learning disability, use of prescription medications, and chronic conditions. However, these attributes are negatively associated with health care access and utilization, suggesting the need for outreach to Asian immigrant populations to educate them on accessing the US health care system.
KW - access
KW - Asians
KW - children
KW - Chinese
KW - ethnic groups
KW - health services
KW - immigrants
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043033383&site=ehost-live&scope=site
UR - email: syu@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of reverse transcription and PCR to discriminate between infectious and non-infectious hepatitis A virus.
AU - Bhattacharya, S. S.
AU - Kulka, M.
AU - Lampel, K. A.
AU - Cebula, T. A.
AU - Goswami, B. B.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004///
VL - 116
IS - 2
SP - 181
EP - 187
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Bhattacharya, S. S.: Division of Molecular Biology, HFS-025, Office of Applied Research and Safety Assessment, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20043029470. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - Hepatitis A virus (HAV) is a major cause of infectious hepatitis worldwide. Detection of HAV in contaminated food or water is a priority research area in laboratories worldwide. Our laboratory has reported previously the development of reverse transcription-polymerase chain reaction (RT-PCR) based detection and typing methods for HAV in contaminated shellfish and produce. It is commonly held that RT-PCR can detect viral genome, but cannot distinguish between infectious and inactivated virus. Therefore, signals obtained after PCR should be considered as false positives unless it can be shown that the sample contains virus capable of infecting a suitable host cell line in culture. We present data to show that this general assumption is not valid. Evidence is provided that demonstrate that signals generated after RT-PCR amplification of viral genome correlated well with the presence of infectious virus in the sample. Viral samples inactivated by heat or UV treatment produced significantly lower signal strength that paralleled infectivity of the sample in cultured cells. The loss of signal strength is most likely the result of damage to the viral RNA that renders it unsuitable for RT-PCR. The correlation between PCR signal and infectivity was better following UV inactivation than heat treatment. The procedure may be adapted to other viruses and inactivating agents.
KW - diagnostic techniques
KW - differential diagnosis
KW - foodborne diseases
KW - hepatitis A
KW - human diseases
KW - polymerase chain reaction
KW - reverse transcription
KW - hepatitis A virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Diagnosis of Animal Diseases (LL886) (New March 2000)
KW - Microbial Technology in Food Processing (QQ120)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043029470&site=ehost-live&scope=site
UR - email: bgoswami@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Herpes simplex virus type-2 specific glycoprotein G-2 immunomagnetically captured from HEp-2 infected tissue culture extracts.
AU - Clavet, C. R.
AU - Margolin, A. B.
AU - Regan, P. M.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004///
VL - 119
IS - 2
SP - 121
EP - 128
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Clavet, C. R.: US Food and Drug Administration, Winchester Engineering and Analytical Center, Winchester, MA 01890, USA.
N1 - Accession Number: 20043104984. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health
N2 - Monoclonal antibody H1206 anti-HSV-2 gG-2 bound to tosylactivated paramagnetic Dynabeads® (Dynal®) has been used to isolate HSV-2 type-specific gG-2 from solubilized HEp-2 HSV-2 infected cell extracts. The immunomagnetically captured type-specific glycoprotein reacted strongly with monoclonal antibody H1206 and demonstrated a single band with apparent molecular weight of 100 000 (100 kDa) and a doublet band with an apparent molecular weight of 60 000-64 000 (60-64 kDa). We observed the same exact banding pattern when monoclonal H1206 was immunoblotted with Helix pomatia lectin purified HSV-2 gG-2. The immunomagnetically purified gG-2 was unreactive to monoclonal antibody H1379 anti-HSV-1 gG-1 and four human HSV antibody negative sera. In addition, 20 human HSV antibody positive sera obtained from the Centers for Disease Control (CDC), Atlanta, GA, were used for the evaluation of our methodology. Immunoblotting of the human HSV antibody positive samples were in agreement with the CDC HSV serological designation. Sera characterized by reactivity to the immunomagnetically purified gG-2 in conjunction with Western blot has the potential to be used as a confirmatory serological test or to determine the accuracy of clinical serological immunoassays used to determine HSV-2 seropositivity.
KW - glycoproteins
KW - human diseases
KW - immunoassay
KW - monoclonal antibodies
KW - tissue culture
KW - Human herpesvirus 2
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Simplexvirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - herpes simplex virus 2
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043104984&site=ehost-live&scope=site
UR - email: cclavet@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV.
AU - Darnell, M. E. R.
AU - Subbarao, K.
AU - Feinstone, S. M.
AU - Taylor, D. R.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004///
VL - 121
IS - 1
SP - 85
EP - 91
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0166-0934
AD - Darnell, M. E. R.: Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, HFM448, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043165903. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 111-30-8. Subject Subsets: Agricultural Biotechnology; Public Health
N2 - Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment laboratories at biosafety level 3 (BSL3). The virus was inactivated by ultraviolet light (UV) at 254 nm, heat treatment of 65°C or greater, alkaline (pH>12) or acidic (pH<3) conditions, formalin and glutaraldehyde treatments. We describe the kinetics of these efficient viral inactivation methods, which will allow research with SARS-CoV containing materials, that are rendered non-infectious, to be conducted at reduced safety levels.
KW - acidity
KW - alkalinity
KW - glutaraldehyde
KW - heat treatment
KW - human diseases
KW - inactivation
KW - kinetics
KW - severe acute respiratory syndrome
KW - ultraviolet radiation
KW - viral diseases
KW - Coronavirus
KW - man
KW - Coronaviridae
KW - Nidovirales
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Coronavirus
KW - formalin
KW - heat processing
KW - SARS
KW - SARS coronavirus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043165903&site=ehost-live&scope=site
UR - email: taylord@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Work-related asthma-like symptoms among florists.
AU - Akpinar-Elci, M.
AU - Elci, O. C.
AU - Odabasi, A.
JO - Chest
JF - Chest
Y1 - 2004///
VL - 125
IS - 6
SP - 2336
EP - 2339
CY - Northbrook; USA
PB - American College of Chest Physicians
SN - 0012-3692
AD - Akpinar-Elci, M.: Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Field Studies Branch, MS H-2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043184288. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Weeds
N2 - Objectives: In this study, we evaluated the prevalence of work-related asthma-like symptoms and possible risk factors among florists in Turkey. Methods: We collected questionnaire data from 128 florists, and investigated occupational history and respiratory, ocular, dermal, and nasal symptoms. We evaluated pulmonary function tests with spirometry and atopy by using the skin-prick test. Possible risk factors were analyzed by age-adjusted, smoking-adjusted, and gender-adjusted logistic regression models comparing symptomatic and asymptomatic individuals. Results: The prevalence of work-related asthma-like symptoms was 14.1% (18 patients). We observed excess risk with a high work intensity (odds ratio [OR], 7.3; 95% confidence interval [CI], 1.1 to 51.8) and long work duration (OR, 5.1; 95% CI, 1.2 to 21.6). Florists with work-related asthma-like symptoms were 5.9 times more likely (95% CI, 1.4 to 24.3) to have a positive skin test response to a flower mix allergen. We also observed an excess risk for work-related asthma-like symptoms among those with allergic rhinitis (OR, 13.2; 95% CI, 3.1 to 56.4) and conjunctivitis (OR, 8.4; 95% CI, 2.4 to 29.2). Conclusion: The most prominent risk factors in florists were work intensity, work duration, and specific atopy.
KW - allergens
KW - allergies
KW - asthma
KW - clinical aspects
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - pollen
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clinical picture
KW - florists
KW - Weeds and Noxious Plants (FF500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043184288&site=ehost-live&scope=site
UR - http://www.chestjournal.org/cgi/content/abstract/125/6/2336
UR - email: mra8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Linezolid and vancomycin for methicillin-resistant Staphylococcus aureus nosocomial pneumonia: the subtleties of subgroup analyses.
AU - Powers, J. H.
AU - Ross, D. B.
AU - Lin, D.
AU - Soreth, J.
JO - Chest
JF - Chest
Y1 - 2004///
VL - 126
IS - 1
SP - 314
EP - 315
CY - Northbrook; USA
PB - American College of Chest Physicians
SN - 0012-3692
AD - Powers, J. H.: US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20043199910. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 1404-93-9, 61-32-5, 1404-90-6, 165800-03-3. Subject Subsets: Public Health
N2 - This article presents several concerns regarding the analysis of subgroups in clinical trials of linezolid and vancomycin against methicillin resistant Staphylococcus aureus in patients with nosocomial pneumonia. The difficulties associated with the use of subgroup analysis to draw conclusions are discussed. Clinicians should exercise care in drawing conclusions based on subgroup analyses alone.
KW - antibacterial agents
KW - bacterial diseases
KW - bacterial pneumonia
KW - drug resistance
KW - human diseases
KW - linezolid
KW - methicillin
KW - nosocomial infections
KW - vancomycin
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - hospital infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043199910&site=ehost-live&scope=site
UR - http://www.chestjournal.org/
UR - email: POWERSJOH@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Simultaneous analysis of hepatotoxic pyrrolizidine alkaloids and N-oxides in comfrey root by LC-ion trap mass spectrometry.
AU - Wuilloud, J. C. A.
AU - Gratz, S. R.
AU - Gamble, B. M.
AU - Wolnik, K. A.
JO - Analyst
JF - Analyst
Y1 - 2004///
VL - 129
IS - 2
SP - 150
EP - 156
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 0003-2654
AD - Wuilloud, J. C. A.: US Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA.
N1 - Accession Number: 20043032127. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Ornamnental Horticulture; Aromatic & Medicinal Plants; Horticultural Science
N2 - The purpose of the current study was to develop a LC-MSn method for the analysis of pyrrolizidine alkaloids (PAs) in comfrey. Published data presents an extensive list of PAs and their N-oxides present in comfrey. However, standards are not commercially available for any of the PAs typically present in comfrey. Those PAs that are not stereoisomers were readily resolved on a C18 column using a water-acetonitrile gradient as the mobile phase. The use of a selective technique, LC-MS/MS, allowed us to identify groups of PAs and their N-oxides, as well as identify the number of PAs present in each group, including those that were not completely resolved chromatographically.
KW - adverse effects
KW - chemical composition
KW - hepatotoxins
KW - liver
KW - mass spectrometry
KW - medicinal plants
KW - medicinal properties
KW - methodology
KW - plant composition
KW - plant extracts
KW - pyrrolizidine alkaloids
KW - roots
KW - toxicity
KW - Symphytum officinale
KW - Symphytum uplandicum
KW - Symphytum
KW - Boraginaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - adverse reactions
KW - Boraginales
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - methods
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043032127&site=ehost-live&scope=site
UR - email: sgratz@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for hepatitis C virus infection in adults: recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2004///
VL - 140
IS - 6
SP - 462
EP - 464
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20043055655. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 3 ref. Subject Subsets: Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for hepatitis C, which are based on the USPSTF's examination of evidence specific to asymptomatic persons for hepatitis C virus (HCV) testing and treatment. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the summary of the evidence and systematic evidence review on this topic. The complete USPSTF recommendation statement (which includes a brief review of the supporting evidence), the accompanying journal article, and the complete systematic evidence review are available through the USPSTF web site (http://www.preventiveservices.ahrq.gov). The journal article and the USPSTF recommendation statement are available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov).
KW - adults
KW - diagnosis
KW - guidelines
KW - hepatitis C
KW - human diseases
KW - screening
KW - USA
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - recommendations
KW - screening tests
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043055655&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening and behavioral counseling interventions in primary care to reduce alcohol misuse: recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2004///
VL - 140
IS - 7
SP - 554
EP - 556
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20043061493. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on behavioural counselling interventions to reduce alcohol misuse in primary care patients and updates the 1996 recommendations on this topic. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the systematic evidence review on this topic. The complete USPSTF recommendation statement (which includes a brief review of the supporting evidence), the accompanying journal article, and the complete systematic evidence review are available through the USPSTF Web site (www.preventiveservices.ahrq.gov). The journal article and the USPSTF recommendation statement are available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov).
KW - alcohol intake
KW - alcoholic beverages
KW - alcoholism
KW - behaviour modification
KW - counselling
KW - guidelines
KW - primary health care
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - behavior modification
KW - counseling
KW - recommendations
KW - screening tests
KW - United States of America
KW - Health Services (UU350)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043061493&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Headache, stomachache, backache, and morning fatigue among adolescent girls in the United States: associations with behavioral, sociodemographic, and environmental factors.
AU - Ghandour, R. M.
AU - Overpeck, M. D.
AU - Huang, Z. J.
AU - Kogan, M. D.
AU - Scheidt, P. C.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2004///
VL - 158
IS - 8
SP - 797
EP - 803
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Ghandour, R. M.: Offices of Women's Health, Health Resources and Services Administration, Parklawn Bldg, Room 10C-09, 5600 Fishers Lane, Rockville, MD 20857, USA.
N1 - Accession Number: 20043146494. Publication Type: Journal Article. Language: English. Number of References: 60 ref. Subject Subsets: Public Health
N2 - Background: Data on the prevalence and co-occurrence of multiple somatic symptoms among US adolescent females as they are influenced by sociodemographic, behavioural, and environmental factors is limited. Objectives: To describe the health status of adolescent US females measured by the prevalence, frequency, and co-occurrence of headache, stomach ache, backache, and morning fatigue and to investigate associations between selected risk and protective factors. Design, Setting, and Participants: School-based, cross-sectional, nationally representative survey of adolescents in the 6th through 10th grades in the USA. Data collected between 1997 and 1998. Main Outcome Measures: Prevalence of headache, stomach ache, backache, and morning fatigue. Results: Among US adolescent girls, 29.1% experience headaches, 20.7% report stomach aches, 23.6% experience back pain, and 30.6% report morning fatigue at the rate of more than once a week. Co-occurrence of somatic complaints is common. Among girls who experienced headaches more than once a week, 3.2 million (53.3%) also reported stomach pain more than once a week and 4.1 million (74.3%) reported morning fatigue more than once a week. Heavy alcohol use, high caffeine intake, and smoking cigarettes every day were strongly associated with all symptoms, while parent and teacher support served as protective factors. Conclusions: Somatic complaints of headache, stomach ache, backache, and morning fatigue are common among US adolescent girls and co-occur often. Effective clinical treatment of this population requires comprehensive assessment of all female adolescents presenting with seemingly isolated somatic complaints.
KW - adolescents
KW - back
KW - behaviour
KW - children
KW - environmental factors
KW - fatigue
KW - girls
KW - headaches
KW - pain
KW - risk factors
KW - stomach
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - teenagers
KW - tiredness
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043146494&site=ehost-live&scope=site
UR - email: Rghandour@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence and characteristics of children with special health care needs.
AU - Dyck, P. C. van
AU - Kogan, M. D.
AU - McPherson, M. G.
AU - Weissman, G. R.
AU - Newacheck, P. W.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2004///
VL - 158
IS - 9
SP - 884
EP - 890
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Dyck, P. C. van: Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20043170448. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Background: Children with special health care needs (SHCNs) are an important population from health care services, economic, and policy perspectives. However, until recently, no national data on their prevalence and health care service needs that use a commonly accepted definition have existed. Objective: To provide national estimates of the number of children with SHCNs and their characteristics, including an assessment of how well their needs are being met. Setting: The United States. Participants: Interviews were conducted by telephone with the families of 38 866 children with SHCNs younger than 18 years using the State and Local Area Integrated Telephone Survey platform developed by the Centers for Disease Control and Prevention, Atlanta, Ga. Main Outcome Measures: Prevalence of SHCNs, demographic and socioeconomic correlates of SHCNs, access to care, satisfaction with care, and impact on the family. Results: An estimated 12.8% of US children experienced an SHCN in 2001. Prevalence was highest among boys, school-age children, and children in lower-income families. A substantial minority of these children experienced unmet health needs (17.7%) or lacked critical elements of family-centered health care (33.5%). The impact on families was pronounced, as 20.9% reported their child's health care caused financial problems, and 29.9% reported cutting back or quitting work because of their child's condition. These adverse child- and family-level impacts were concentrated among low-income and uninsured children with SHCNs. Conclusions: Children with SHCNs and their families represent an important underserved population. In addition, substantial disparities are present in access, satisfaction, and family impact.
KW - children
KW - costs
KW - demography
KW - disabilities
KW - ethnic groups
KW - ethnicity
KW - families
KW - health care
KW - health policy
KW - human diseases
KW - low income groups
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - ethnic differences
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Policy and Planning (EE120)
KW - Demography (UU200)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043170448&site=ehost-live&scope=site
UR - email: mkogan@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CYP3A4 polymorphisms - potential risk factors for breast and prostate cancer: a HuGE review.
AU - Keshava, C.
AU - McCanlies, E. C.
AU - Weston, A.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2004///
VL - 160
IS - 9
SP - 825
EP - 841
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Keshava, C.: Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-L3014, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20043195694. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 9035-51-2. Subject Subsets: Public Health
N2 - The steroid hydroxylase CYP3A4 is the most abundant P-450 enzyme in the human liver, and CYP3A enzymes metabolize more than 50% of prescription drugs. The CYP3A4 gene is expressed in the liver, gut, colon, prostate, and breast. Individual variation in CYP3A4 may play a role in breast and prostate carcinogenesis through modulation of sex hormone metabolite levels. Alternatively, CYP3A4 can metabolically activate exogenous carcinogens. CYP3A4 activity varies widely in humans, and more than 78 DNA sequence polymorphisms are known. These observations prompted the hypothesis that variant CYP3A4 may be involved in breast and prostate cancer. Two epidemiologic studies of breast cancer and five of prostate cancer examined CYP3A4 genotypes. A US study showed that inheritance of CYP3A4*1B correlates with early menarche, a breast cancer risk factor. However, an Australian breast cancer case-control study found no association with CYP3A4*1B. Two Scottish prospective studies showed CYP3A4*1B to be a risk factor for prostate cancer among men with benign prostatic hyperplasia. Three other studies were undertaken in the United States: two were case-only studies and the other was a case-sibling control study. Although results for African Americans were inconsistent, these studies suggested that CYP3A4*1B was associated with markers of advanced disease. These observations support the notion that development of robust, conventional molecular epidemiologic case-control studies to address these questions, including gene-gene and gene-environment interactions, will be timely.
KW - breast
KW - breast cancer
KW - carcinogenesis
KW - cytochrome P-450
KW - genetic polymorphism
KW - genetics
KW - genomes
KW - genotypes
KW - human diseases
KW - men
KW - menarche
KW - molecular epidemiology
KW - neoplasms
KW - predisposition
KW - prostate
KW - prostate cancer
KW - reviews
KW - risk factors
KW - sex hormones
KW - susceptibility
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breasts
KW - cancers
KW - Human Reproduction and Development (VV060)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043195694&site=ehost-live&scope=site
UR - email: agw8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Clinicians' perceptions of the problem of antimicrobial resistance in health care facilities.
AU - Giblin, T. B.
AU - Sinkowitz-Cochran, R. L.
AU - Harris, P. L.
AU - Jacobs, S.
AU - Liberatore, K.
AU - Palfreyman, M. A.
AU - Harrison, E. I.
AU - Cardo, D. M.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2004///
VL - 164
IS - 15
SP - 1662
EP - 1668
CY - Chicago; USA
PB - American Medical Association
SN - 0003-9926
AD - Giblin, T. B.: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20043141223. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Background: Many clinicians do not comply with guidelines regarding antimicrobial resistance (AR). In response, the Centers for Disease Control and Prevention developed a national Campaign to Prevent Antimicrobial Resistance in Healthcare Settings that presents 4 strategies and 12 evidence-based steps. Methods: To assess clinicians' perceptions of AR, barriers and facilitators to preventing AR, and how best to reach clinicians, a questionnaire and 4 focus groups were conducted after presentation of the Campaign at 4 Pittsburgh Regional Healthcare Initiative hospitals. Results: One hundred seventeen clinicians completed the questionnaire; 28 participated in the focus groups. Clinicians were significantly more likely to perceive that AR was a problem nationally than in their own institution (95% vs 77%; P<0.001) or practice (95% vs 65%; P=0.002), consistent with focus group results (93% nationally vs 46% institution or practice). The 3 Campaign steps with the most barriers to implementation were "Treat infection, not colonization" (35%), "Stop treatment when infection is cured or unlikely" (35%), and "Practice antimicrobial control" (33%). Clinicians in the focus groups cited the additional barriers of the health care culture, lack of knowledge, and the nursing shortage; facilitators included education, information technology, and consults. Computer programs, posters, and local data were suggested for reaching clinicians about AR. Conclusions: Clinicians perceive AR to be a complex national problem but less relevant to their own institution or practice. Providing clinicians with information and steps for preventing AR, as in the Campaign, may affect their perceptions of the problem and motivate them to take actions to ensure patient safety.
KW - antiinfective agents
KW - attitudes
KW - drug resistance
KW - drug therapy
KW - infections
KW - prescriptions
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - chemotherapy
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043141223&site=ehost-live&scope=site
UR - email: rls7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population.
AU - Tarkowski, T. A.
AU - Koumans, E. H.
AU - Sawyer, M.
AU - Pierce, A.
AU - Black, C. M.
AU - Papp, J. R.
AU - Markowitz, L.
AU - Unger, E. R.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004///
VL - 189
IS - 1
SP - 46
EP - 50
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Tarkowski, T. A.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Rd., MSG41, Atlanta, GA 30333, USA.
N1 - Accession Number: 20043037394. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - We determined the prevalence of and the risk factors for human papillomavirus (HPV) infection and abnormal cytologic test results in 312 adolescent girls (mean age, 16.1 years). Subjects had a median of 2 years of sexual activity and 4 lifetime sex partners. Cervical HPV was detected by use of L1-consensus polymerase chain reaction in 64% of subjects; half of those with HPV had >1 type, and 77% had ≥1 high-risk type. Independent risk factors for HPV were lifetime number of sex partners, age of partner, and douching. Cytologic abnormalities were common (20.9% of subjects had atypical squamous cells of uncertain significance, and 17.0% had high- or low-grade squamous intraepithelial lesions) and were significantly associated with detection of HPV (P=.0001); however, most (51.6%) subjects with HPV had normal cytologic test results.
KW - adolescents
KW - cervical cancer
KW - cervix
KW - children
KW - disease prevalence
KW - epidemiology
KW - girls
KW - human diseases
KW - neoplasms
KW - risk factors
KW - sexual behaviour
KW - sexual partners
KW - sexually transmitted diseases
KW - urban areas
KW - viral diseases
KW - Georgia
KW - USA
KW - human papillomaviruses
KW - man
KW - Papillomavirus
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - Papillomaviridae
KW - cancers
KW - human papillomavirus
KW - Papovaviridae
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - STDs
KW - teenagers
KW - United States of America
KW - venereal diseases
KW - viral infections
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043037394&site=ehost-live&scope=site
UR - email: eunger@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection.
AU - Dybul, M.
AU - Nies-Kraske, E.
AU - Dewar, R.
AU - Maldarelli, F.
AU - Hallahan, C. W.
AU - Daucher, M.
AU - Piscitelli, S. C.
AU - Ehler, L.
AU - Weigand, A.
AU - Palmer, S.
AU - Metcalf, J. A.
AU - Davey, R. T.
AU - Kress, D. M. R.
AU - Powers, A.
AU - Beck, I.
AU - Frenkel, L.
AU - Baseler, M.
AU - Coffin, J.
AU - Fauci, A. S.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004///
VL - 189
IS - 11
SP - 1974
EP - 1982
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Dybul, M.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Department of Health and Human Services, Bldg. 31/Rm. 7A-03, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043115525. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 69655-05-6, 154598-52-4, 134678-17-4. Subject Subsets: Public Health
N2 - Background. We previously demonstrated that short-cycle structured intermittent therapy (SIT; 7 days without therapy followed by 7 days with antiretroviral therapy [ART]) with a ritonavir-boosted, indinavir-based, twice-daily regimen maintained suppression of plasma HIV viremia while reducing serum levels of lipids. Adherence to such a regimen may be problematic for certain patients. Methods. Eight patients with a history of receiving combination ART that maintained suppression of plasma HIV RNA to <50 copies/mL received a once-daily SIT regimen of didanosine, lamivudine, and efavirenz. Results. For 7 patients, suppression of plasma HIV RNA to <50 copies/mL was maintained for 60-84 weeks. Four patients with adequate samples had no evidence for an increase in plasma viremia for up to 72 weeks, by use of an assay with a limit of detection of <1 copy/mL. The lack of rebound viremia may be the result of the persistence of efavirenz in plasma on day 7 of the no-therapy period, as was detected in 7 of 7 patients. There was no significant change in CD4+ T cell counts or serum hepatic transaminase or lipid levels. Conclusion. A once-daily short-cycle SIT regimen maintained suppression of plasma HIV RNA while preserving CD4+ T cell counts. Such a regimen may have importance in resource-limited settings where the monetary cost of continuous ART is prohibitive.
KW - antiretroviral agents
KW - antiviral agents
KW - blood plasma
KW - CD4+ lymphocytes
KW - chronic infections
KW - didanosine
KW - efavirenz
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - lamivudine
KW - multiple drug therapy
KW - regimens
KW - viraemia
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - CD4+ cells
KW - combination drug therapy
KW - dideoxyinosine
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - plasma (blood)
KW - structured intermittent therapy
KW - T4 lymphocytes
KW - United States of America
KW - viremia
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043115525&site=ehost-live&scope=site
UR - email: mdybul@nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of immunogenicity and protective properties of inactivated poliovirus vaccines: a new surrogate method for predicting vaccine efficacy.
AU - Dragunsky, E. M.
AU - Ivanov, A. P.
AU - Wells, V. R.
AU - Ivshina, A. V.
AU - Rezapkin, G. V.
AU - Abe, S.
AU - Potapova, S. G.
AU - Enterline, J. C.
AU - Hashizume, S.
AU - Chumakov, K. M.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004///
VL - 190
IS - 8
SP - 1404
EP - 1412
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Dragunsky, E. M.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20043199743. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Agricultural Biotechnology
N2 - An assay for the evaluation of protective properties of inactivated poliovirus vaccines (IPVs) in transgenic (Tg) mice susceptible to poliovirus has been developed and optimized for type 2 IPV. This method was used to compare the immunogenicity and protective properties of experimental IPV produced from the attenuated Sabin strain (sIPV) with those of conventional IPV (cIPV) produced from the wild-type (wt) poliovirus MEF-1 strain. Modified enzyme-linked immunosorbent assays (ELISAs) were used to measure immune response in serum and saliva samples from test mice. Tg mice were vaccinated and were challenged either with wt poliovirus or virulent poliovirus derived from the vaccine strain. Compared with cIPV, sIPV induced lower levels of antibodies and did not completely protect mice against challenge with wt virus but did protect mice against challenge with the virulent vaccine-derived strain. This may be due to an 18% nucleotide difference between the MEF-1 and Sabin 2 strains, resulting in 72 amino acid substitutions and leading to antigenic dissimilarity. Immunological properties of both strains, revealed by cross-neutralization tests and ELISAs, confirmed that MEF-1 possesses broader immunogenicity than does Sabin 2. This animal model may be used for the assessment of new IPVs and of combination vaccines containing an IPV component.
KW - animal models
KW - antigens
KW - human diseases
KW - immune response
KW - immunization
KW - inactivated vaccines
KW - laboratory animals
KW - vaccination
KW - human poliovirus 2
KW - man
KW - mice
KW - Poliovirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - antigenicity
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - killed vaccines
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043199743&site=ehost-live&scope=site
UR - email: dragunsky@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Arsenic and atherosclerosis.
AU - Simeonova, P. P.
AU - Luster, M. I.
T3 - Special issue: Arsenic in biology and medicine
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2004///
VL - 198
IS - 3
SP - 444
EP - 449
CY - Orlando; USA
PB - Academic Press
SN - 0041-008X
AD - Simeonova, P. P.: Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043216302. Publication Type: Journal Article. Note: Special issue: Arsenic in biology and medicine Language: English. Registry Number: 7440-38-2, 10102-43-9.
N2 - Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis.
KW - animal models
KW - apolipoproteins
KW - arsenic
KW - atherosclerosis
KW - blood vessels
KW - endothelium
KW - epidemiology
KW - exposure
KW - human diseases
KW - inflammation
KW - laboratory animals
KW - nitric oxide
KW - occupational hazards
KW - occupational health
KW - physiopathology
KW - reviews
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - arteriosclerosis
KW - pathophysiology
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043216302&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4BXN6BB-5&_user=10&_handle=B-WA-A-W-WY-MsSAYWA-UUW-AAUDZDAABD-AAUCWCAEBD-YVWYUCVWZ-WY-U&_fmt=summary&_coverDate=08%2F01%2F2004&_rdoc=23&_orig=browse&_srch=%23toc%237159%232004%23998019996%23512032!&_cdi=7159&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6a0226155c767cd7df84b604cab8762d
UR - email: psimeonova@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of CpG oligodeoxynucleotides as immune adjuvants.
AU - Klinman, D. M.
AU - Currie, D.
AU - Gursel, I.
AU - Verthelyi, D.
JO - Immunological Reviews
JF - Immunological Reviews
Y1 - 2004///
VL - 199
IS - 1
SP - 201
EP - 216
CY - Copenhagen; Denmark
PB - Munksgaard International Publishers Ltd
SN - 0105-2896
AD - Klinman, D. M.: Section of Retroviral Immunology, Building 29A, Room 3D10, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043096182. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of T helper 1 (Th1) and pro-inflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5-500-fold. These effects are optimized by maintaining close physical contact between the CpG DNA and the immunogen. Animal challenge models establish that protective immunity can be accelerated and magnified by coadministering CpG DNA with vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans, and in some cases, they increase vaccine-induced immune responses.
KW - adjuvants
KW - antigens
KW - human diseases
KW - immune response
KW - immunization
KW - immunostimulants
KW - reviews
KW - vaccination
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043096182&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/links/doi/10.1111/j.0105-2896.2004.00148.x/abs/
UR - email: klinman@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the potential immunotoxicity of 3-monochloro-1,2-propanediol in Balb/c mice. I. Effect on antibody forming cell, mitogen-stimulated lymphocyte proliferation, splenic subset, and natural killer cell activity.
AU - Lee JongKwon
AU - Byun, J. A.
AU - Park SeungHee
AU - Kim HyungSoo
AU - Park JaeHyun
AU - Eom, J. H.
AU - Oh HyeYoung
JO - Toxicology
JF - Toxicology
Y1 - 2004///
VL - 204
IS - 1
SP - 1
EP - 11
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0300-483X
AD - Lee JongKwon: Division of Immunotoxicology, National Institute of Toxicological Korea Food and Drug Administration, 122-704, Seoul, Korea Republic.
N1 - Accession Number: 20043181002. Publication Type: Journal Article. Language: English. Subject Subsets: Soyabeans
N2 - 3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. MCPD has been reported genotoxic in vitro, and reproductive toxicity and carcinogenicity in rats. However, no previous studies have investigated MCPD-induced alterations in the immune system. In the present study, MCPD was administered by gavage for 14 days at 0, 25, 50, and 100 mg/kg per day to female Balb/c mice. The antibody-mediated immune response to sheep red blood cells (SRBC) was assessed using the antibody-forming cell (AFC) assay, and splenic cell phenotypes were quantified by flow cytometry. Hematological and histopathological changes were assessed. Mitogen-stimulated spleen lymphocyte proliferation and natural killer (NK) cell activity were evaluated. The T-lymphocyte blastogenesis by concanavalin A (Con A) or anti-CD3 and B-lymphocyte blastogenesis by lipopolysaccharide (LPS) were not significantly changed. There were no significant changes in the hematological and histopathological findings of MCPD-treated mice. However, the significant decrease in thymus weight was observed in 100 mg dose group, even though that did not change body weight gain. The cellularities of spleen and thymus were significantly reduced in high-dose group. Exposure to high dose of MCPD decreased the AFC response to SRBC in mice. There was a significant decrease in NK cell activity of mice treated with high dose of MCPD. These results indicate that MCPD could modulate the immune function in Balb/c mice.
KW - animal models
KW - food processing
KW - immune response
KW - immune system
KW - laboratory animals
KW - lymphocyte transformation
KW - natural killer cells
KW - soya sauce
KW - spleen
KW - thymus gland
KW - toxicity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 3-monochloro-1,2-propanediol
KW - immunity reactions
KW - immunological reactions
KW - soy sauce
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043181002&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4CHJ8K9-1&_user=10&_handle=B-WA-A-W-Y-MsSAYWW-UUA-AAUWZZADZW-AAUUWVWCZW-DBDWUCUZV-Y-U&_fmt=summary&_coverDate=11%2F01%2F2004&_rdoc=1&_orig=browse&_srch=%23toc%235175%232004%23997959998%23519629!&_cdi=5175&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=b320aaadcbc0065d5cad7fcbc1b87269
UR - email: jkleest@kfda.go.kr\jkleest@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer.
AU - Ratnasinghe, L. D.
AU - Abnet, C.
AU - Qiao YouLin
AU - Modali, R.
AU - Stolzenberg-Solomon, R.
AU - Dong ZhiWei
AU - Dawsey, S. M.
AU - Mark, S. D.
AU - Taylor, P. R.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004///
VL - 216
IS - 2
SP - 157
EP - 164
CY - Oxford; UK
PB - Elsevier Science Ltd
SN - 0304-3835
AD - Ratnasinghe, L. D.: Center for Structural Genomics, NCTR, Food and Drug Administration, National Center for Toxicological Research/FDA, 3900 NCTR Drive, Jefferson, Arkansas, AR 72079-9502, USA.
N1 - Accession Number: 20043210011. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases
N2 - Background: Linxian, a rural county in North Central China, has among the highest rates of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in the world. In a nested case-cohort study that originated from two cancer prevention trials in Linxian, we examined the relationship between these cancers and two polymorphisms in the DNA repair gene XRCC1. Methods: We conducted a case-cohort study among individuals in the cohort who were alive and cancer free in 1991, and had blood samples for DNA extraction. Real time Taqman analyses were conducted to genotype incident cancer cases (n=221, 131 esophageal and 90 gastric cardia cancer cases) that developed through May 1996, and on an age- and sex-matched reference cohort (n=454). We used Cox proportional hazard models to estimate relative risks (RR) and 95% confidence intervals (95% CI). Results: We observed no association between the variant genotype in XRCC1 Arg194Trp (codon 194 arganine to tryptophan substitution) and esophageal or gastric cardia cancer. However, carrying at least one copy of the variant allele in XRCC1 Arg399Gln (codon 399 arganine to glutamine substitution) was associated with reduced risk of gastric cardia cancer (RR: 0.60, 95% CI: 0.37-0.97) and the combined category esophageal/gastric cancer (RR: 0.67, 95% CI: 0.48-0.95). In combined polymorphisms analyses, we observed a significant reduction in risk of combined esophageal/gastric cancer among individuals that had both the XRCC1 Arg194Trp and Arg399Gln variant genotyopes (RR: 0.47, 95% CI: 0.26-0.84). Conclusions: Our results suggest that the XRCC1 Arg399Gln variant genotype is associated with reduced risk of upper GI cancer and that individuals with both XRCC1 variant genotypes are also at significantly reduced risk of upper GI cancer in this high-risk Chinese population.
KW - alleles
KW - Chinese
KW - genes
KW - genetic polymorphism
KW - genotypes
KW - human diseases
KW - molecular genetics
KW - neoplasms
KW - oesophageal cancer
KW - oesophagus
KW - risk assessment
KW - stomach
KW - stomach cancer
KW - China
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - biochemical genetics
KW - cancers
KW - esophageal cancer
KW - esophagus
KW - People's Republic of China
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043210011&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-4D34NWN-1&_user=10&_handle=B-WA-A-W-AZ-MsSAYZW-UUW-AAUDZDUBUA-AAUCWCAAUA-YVWDEZAVY-AZ-U&_fmt=summary&_coverDate=12%2F28%2F2004&_rdoc=3&_orig=browse&_srch=%23toc%234992%232004%23997839997%23527462!&_cdi=4992&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=15f44a48c8e1f73b82dc900493bf2a0d
UR - email: lratnasinghe@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse drug event reports at the United States Food and Drug Administration Center for Veterinary Medicine.
AU - Hampshire, V. A.
AU - Doddy, F. M.
AU - Post, L. O.
AU - Koogler, T. L.
AU - Burgess, T. M.
AU - Batten, P. O.
AU - Hudson, R.
AU - McAdams, D. R.
AU - Brown, M. A.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2004///
VL - 225
IS - 4
SP - 533
EP - 536
CY - Schaumburg; USA
PB - American Veterinary Medical Association
SN - 0003-1488
AD - Hampshire, V. A.: United States Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Pl, Rockville, MD 20885, USA.
N1 - Accession Number: 20043159228. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 93106-60-6, 113507-06-5. Subject Subsets: Veterinary Science
KW - adverse effects
KW - blindness
KW - databases
KW - drug toxicity
KW - drugs
KW - enrofloxacin
KW - keratoconjunctivitis
KW - moxidectin
KW - non-steroidal antiinflammatory agents
KW - overdose
KW - pharmacodynamics
KW - poisoning
KW - safety
KW - toxicity
KW - USA
KW - cats
KW - dogs
KW - horses
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - data banks
KW - drug action
KW - mechanism of drug action
KW - medicines
KW - NSAIDS
KW - pharmaceuticals
KW - toxicosis
KW - United States of America
KW - Information and Documentation (CC300)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pets and Companion Animals (LL070)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043159228&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Purification of a constitutive chitosanase produced by Bacillus sp. MET 1299 with cloning and expression of the gene.
AU - Kim, P. I.
AU - Kang TaeHeung
AU - Chung KyoungJin
AU - Kim InSeon
AU - Chung KiChul
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004///
VL - 240
IS - 1
SP - 31
EP - 39
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 0378-1097
AD - Kim, P. I.: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.
N1 - Accession Number: 20043198973. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9041-22-9, 1398-61-4, 9012-76-4. Subject Subsets: Public Health
N2 - A chitosanase produced constitutively by Bacillus sp. MET 1299 was purified by SP-Sephadex column chromatography. The molecular weight was estimated to be 52 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Optimal enzyme activity was observed at a pH of 5.5 and temperature of 60°C. The purified chitosanase showed high activity on 90% deacetylated colloidal chitosan and β-glucan, but not on hydrolyzed colloidal chitin, CMC, or their derivatives. The N-terminal amino acid sequence of the enzyme was determined. The cloned full length gene, 1362 bp in size, encoded a single peptide of 453 amino acids and had a conserved amino acid sequence of glycosyl hydrolase family 8. A search of the cDNA sequence with NCBI BLAST showed homology with chitosanase of Bacillus sp. KTCC 0377BP and Bacillus sp. No. 7-M. The recombinant protein was expressed in Escherichia coli, purified using affinity chromatography and characterized.
KW - beta-glucan
KW - chitin
KW - chitosan
KW - DNA cloning
KW - enzyme activity
KW - gene expression
KW - Bacillus
KW - chitosanase
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043198973&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03781097
UR - email: chungkc@chonnam.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract.
AU - Ding, M.
AU - Lu, Y. J.
AU - Bowman, L.
AU - Huang, C. S.
AU - Leonard, S.
AU - Wang, L. Y.
AU - Vallyathan, V.
AU - Castranova, V.
AU - Shi, X. L.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004///
VL - 279
IS - 11
SP - 10670
EP - 10676
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Ding, M.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20043054081. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - Consumption of fruits and vegetables has been associated with a low incidence of cancers and other chronic diseases. Previous studies suggested that fresh apples inhibit tumor cell proliferation. Here we report that oral administration of apple peel extracts decreased the number of nonmalignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz(a)anthracene-initiated mouse skin. ESR analysis indicated that apple extract strongly scavenged hydroxyl (OH) and superoxide (O2) radicals. Mechanistic studies showed that pretreatment with apple peel extract inhibited AP-1 transactivation induced by ultraviolet B irradiation or TPA in JB6 cells and AP-1-luciferase reporter transgenic mice. This inhibitory effect appears to be mediated by the inhibition of ERKs and JNK activity. The results provide the first evidence that an extract from fresh apple peel extract may inhibit tumor promoter-induced carcinogenesis and associated cell signaling, and suggest that the chemopreventive effects of fresh apple may be through its antioxidant properties by blocking reactive oxygen species-mediated AP-1-MAPK activation.
KW - antineoplastic properties
KW - antioxidants
KW - apples
KW - disease models
KW - laboratory animals
KW - neoplasms
KW - peel
KW - plant extracts
KW - radicals
KW - skin
KW - skin cancer
KW - Malus
KW - mice
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - anti-neoplastic properties
KW - cancers
KW - dermis
KW - Crop Produce (QQ050)
KW - Physiology of Human Nutrition (VV120)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043054081&site=ehost-live&scope=site
UR - email: mid5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anthrax lethal toxin rapidly activates Caspase-1/ICE and induces extracellular release of interleukin (IL)-1β and IL-18.
AU - Cordoba-Rodriguez, R.
AU - Fang, H.
AU - Lankford, C. S. R.
AU - Frucht, D. M.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004///
VL - 279
IS - 20
SP - 20563
EP - 20566
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Cordoba-Rodriguez, R.: Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20043093201. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Anthrax lethal toxin (LT), a critical virulence factor for Bacillus anthracis, has been demonstrated to cleave and to inactivate mitogen-activated protein kinase kinases (MAPKKs) that propagate prosurvival signals in macrophages (1-5). Whether this action of anthrax LT leads to the production of proinflammatory cytokines by macrophages has been more controversial (6, 7). We now report that anthrax LT treatment leads to the specific extracellular release of interleukin (IL)-1β and IL-18 by the murine macrophage cell lines, RAW264.7 and J774A.1. Studies of the processing of IL-1β reveal that the levels of activated/cleaved IL-1β in RAW264.7 and J774.A1 cells are increased following treatment with anthrax LT. Enhanced processing of IL-1β directly correlates with increased levels in the activation of its upstream regulator, IL-1β-converting enzyme/Caspase-1 (ICE). The extracellular release of IL-1β and IL-18 in response to anthrax LT is ICE-dependent, as an ICE-specific inhibitor blocks this process. These data indicate that ICE, IL-1β, and IL-18 are downstream effectors of anthrax LT in macrophages, providing the basis for new bioassays for anthrax LT activity and representing potential therapeutic targets.
KW - animal models
KW - anthrax
KW - bacterial toxins
KW - cell lines
KW - interleukin 1
KW - interleukin 18
KW - interleukins
KW - macrophages
KW - virulence
KW - Bacillus anthracis
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - caspase
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043093201&site=ehost-live&scope=site
UR - email: frucht@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Postlicensure safety surveillance for 7-valent pneumococcal conjugate vaccine.
AU - Wise, R. P.
AU - Iskander, J.
AU - Pratt, R. D.
AU - Campbell, S.
AU - Ball, R.
AU - Pless, R. P.
AU - Braun, M. M.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2004///
VL - 292
IS - 14
SP - 1702
EP - 1710
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Wise, R. P.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-225, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20043178131. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - Context: Clinical trials evaluate a vaccine's safety before approval, but some risks may escape detection or adequate characterization until larger population exposures occur after licensure. Objective: To summarize reports of events occurring after vaccination with 7-valent pneumococcal conjugate vaccine (PCV), including those that may warrant further investigation to assess possible causation by PCV. Design: Descriptive epidemiology of reports submitted to the Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance database. Setting and Patients: USA during first 2 years after licensure of PCV (February 2000 through February 2002). Reports studied were for children younger than 18 years and vaccinated with PCV. Main Outcome Measures: Numbers and proportional distributions of reports. Results: A total of 4154 reports of events following PCV were submitted to VAERS, for a rate of 13.2 reports per 100 000 doses distributed. Multiple vaccines were given in 74.3% of reports. The most frequently reported symptoms and signs included fever, injection site reactions, fussiness, rashes, and urticaria. Serious events were described in 14.6% of reports. There were 117 deaths, 23 reports of positive rechallenges, and 34 cases of invasive pneumococcal infections possibly representing vaccine failure. Immune-mediated events occurred in 31.3% of reports. All 14 patients with anaphylactic or anaphylactoid reactions survived. Thrombocytopenia developed in 14 patients and serum sickness in 6 others. Neurologic symptoms occurred in 38% of reports. Seizures described in 393 reports included 94 febrile seizures. Conclusions: The majority of reports to VAERS in the first 2 years after licensure of PCV described generally minor adverse events previously identified in clinical trials. The proportion of reports portraying serious events was similar to that for other vaccines. Although there are important limitations in passive surveillance data, and caution in their interpretation is necessary, symptoms experienced by a few children more than once after successive PCV doses, including allergic reactions, prolonged or abnormal crying, fussiness, dyspnoea, and gastrointestinal distress, warrant continued surveillance, as do reports of rare but potentially serious events, such as seizures, anaphylactic or anaphylactoid reactions, serum sickness, and thrombocytopenia.
KW - adverse effects
KW - anaphylaxis
KW - bacterial diseases
KW - conjugate vaccines
KW - fever
KW - human diseases
KW - immunization
KW - mortality
KW - safety
KW - seizures
KW - thrombocytopenia
KW - urticaria
KW - vaccination
KW - USA
KW - man
KW - Streptococcus pneumoniae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - anaphylactic reactions
KW - anaphylactic shock
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - death rate
KW - immune sensitization
KW - nettle rash
KW - pyrexia
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043178131&site=ehost-live&scope=site
UR - email: R.P.Wise@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a sensitivity enhanced multiplexed fluorescence covalent microbead immunosorbent assay (FCMIA) for the measurement of glyphosate, atrazine and metolachlor mercapturate in water and urine.
AU - Biagini, R. E.
AU - Smith, J. P.
AU - Sammons, D. L.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Robertson, S. K.
AU - Snawder, J. E.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2004///
VL - 379
IS - 3
SP - 368
EP - 374
CY - Berlin; Germany
PB - Springer-Verlag
SN - 1618-2642
AD - Biagini, R. E.: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676, Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20043110744. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1912-24-9, 38641-94-0, 1071-83-6, 70393-85-0, 51218-45-2. Subject Subsets: Weeds; Public Health
N2 - Body burdens from exposures to pesticides may be estimated from urinary analyses of pesticide parent/metabolite concentrations. Pesticide applicators and others are often exposed to numerous unrelated pesticides, either sequentially or simultaneously. Classically, body burdens of pesticides are analyzed using chemical/instrumental analysis (CIM) or enzyme immunoassays (EIAs). Both of these technologies can usually be used to quantitate one analyte (or closely related groups of analytes) per analysis. Alternatively, multiple analytes can be measured simultaneously using a multiplexed fluorescence covalent microbead immunoassay (FCMIA). We developed a multiplexed FCMIA to simultaneously measure glyphosate (Gly), atrazine (Atz), and metolachlor mercapturate (MM) in water and urine. The assay had least detectable doses (LDDs) in water/diluted urine of 0.11/0.09 ng/ml (Gly, water/urine LDD), 0.10/0.07 ng/ml (Atz), and 0.09/0.03 ng/ml (MM). The sensitivity for the measurement of Gly was enhanced by derivatization. All assays gave linear responses from the LDDs for each respective pesticide to 300 ng/ml. There was no cross-reactivity between the three analytes. Using a 96-well microplate and an autosampler, as many as 288 separate analyses can be completed in ~120 min with precision, sensitivity, and specificity equivalent to, if not better, than that found when these same analytes are measured by CIM or EIA.
KW - assays
KW - atrazine
KW - glyphosate
KW - herbicides
KW - metolachlor
KW - urine
KW - urine analysis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - metolachlor mercapturate
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043110744&site=ehost-live&scope=site
UR - email: reb4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.
AU - Mittelstaedt, R. A.
AU - Mei, N.
AU - Webb, P. J.
AU - Shaddock, J. G.
AU - Dobrovolsky, V. N.
AU - McGarrity, L. J.
AU - Morris, S. M.
AU - Chen, T.
AU - Beland, F. A.
AU - Greenlees, K. J.
AU - Heflich, R. H.
JO - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
Y1 - 2004///
VL - 561
IS - 1/2
SP - 127
EP - 138
CY - Amsterdam; Netherlands
PB - Elsevier Science B.V.
SN - 1383-5718
AD - Mittelstaedt, R. A.: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20043137183. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 569-64-2. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Mycology
N2 - Malachite green, a triphenylmethane dye used in aquaculture as an antifungal agent, is rapidly reduced in vivo to leucomalachite green. Previous studies in which female B6C3F1 mice were fed malachite green produced relatively high levels of liver DNA adducts after 28 days, but no significant induction of liver tumors was detected in a 2-year feeding study. Comparable experiments conducted with leucomalachite green resulted in relatively low levels of liver DNA adducts but a dose-responsive induction of liver tumors. In the present study, we fed transgenic female Big Blue B6C3F1 mice with 450 ppm malachite green and 204 and 408 ppm leucomalachite green (the high doses used in the tumor bioassays) and evaluated genotoxicity after 4 and 16 weeks of treatment. Neither malachite green nor leucomalachite green increased the peripheral blood micronucleus frequency or Hprt lymphocyte mutant frequency at either time point; however, the 16-week treatment with 408 ppm leucomalachite green did increase the liver cII mutant frequency. Similar increases in liver cII mutant frequency were not seen in the mice treated for 16 weeks with malachite green or in female Big Blue rats treated with a comparable dose of leucomalachite green for 16 weeks in a previous study [Mutat. Res. 547 (2004) 5]. These results indicate that leucomalachite green is an in vivo mutagen in transgenic female mouse liver and that the mutagenicities of malachite green and leucomalachite green correlate with their tumorigenicities in mice and rats. The lack of increased micronucleus frequencies and lymphocyte Hprt mutants in female mice treated with leucomalachite green suggests that its genotoxicity is targeted to the tissue at risk for tumor induction.
KW - animal models
KW - antifungal agents
KW - dyes
KW - genotoxicity
KW - human diseases
KW - laboratory animals
KW - liver
KW - lymphocytes
KW - malachite green
KW - mutagenicity
KW - mutagens
KW - mutants
KW - mutations
KW - neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - dyestuffs
KW - fungistats
KW - leucomalachite green
KW - micronucleus
KW - tumourigenicity
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043137183&site=ehost-live&scope=site
UR - email: rmittelstaedt@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety of fresh produce: why is this such an issue today?
AU - Brackett, R. E.
A2 - Looney, N. E.
JO - Acta Horticulturae
JF - Acta Horticulturae
Y1 - 2004///
IS - 642
SP - 137
EP - 144
CY - Leuven; Belgium
PB - International Society for Horticultural Science (ISHS)
SN - 0567-7572
SN - 9066052171
AD - Brackett, R. E.: Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-001, College Park, MD 20740, USA.
N1 - Accession Number: 20053050661. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 2 ref. Subject Subsets: Horticultural Science; Public Health; Human Nutrition
N2 - This article discusses the potential of foodborne pathogens in fresh produce; the incidence of foodborne disease outbreaks; the sources of food contamination (worker hygiene, proximity to animals, water quality, contaminated equipment, poor temperature control, and consumer errors); the factors influencing the apparent increase in foodborne illness; and approaches to improving food safety.
KW - food contamination
KW - foodborne diseases
KW - fresh products
KW - fruits
KW - human diseases
KW - microbial contamination
KW - vegetables
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053050661&site=ehost-live&scope=site
UR - http://www.actahort.org
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulatory requirements for the frying industry.
AU - Firestone, D.
A2 - Gupta, M. K.
A2 - Warner, K.
A2 - White, P. J.
T2 - Frying technology and practices
Y1 - 2004///
CY - Champaign; USA
PB - AOCS Press
SN - 1893997316
AD - Firestone, D.: Food and Drug Administration, Washington, DC 20204, USA.
N1 - Accession Number: 20043187580. Publication Type: Book chapter. Language: English. Number of References: 25 ref.
N2 - The regulations and guidelines for fried foods in terms of food safety and quality control in different countries, viz. USA, Austria, Australia, Belgium, Chile, Czech Republic, France, Germany, Hungary, Iceland, Israel, Italy, Japan, Luxembourg, The Netherlands, Portugal, Singapore, Spain, Switzerland and the Scandinavian countries are discussed.
KW - food processing
KW - food safety
KW - frying
KW - regulations
KW - Australia
KW - Austria
KW - Belgium
KW - Chile
KW - Czech Republic
KW - France
KW - Germany
KW - Hungary
KW - Iceland
KW - Israel
KW - Italy
KW - Japan
KW - Luxembourg
KW - Netherlands
KW - Portugal
KW - Singapore
KW - Spain
KW - Switzerland
KW - USA
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Central Europe
KW - Europe
KW - European Union Countries
KW - Benelux
KW - Western Europe
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Mediterranean Region
KW - EFTA
KW - Scandinavia
KW - Northern Europe
KW - Middle East
KW - West Asia
KW - Asia
KW - Southern Europe
KW - East Asia
KW - Kingdom of the Netherlands
KW - ASEAN Countries
KW - South East Asia
KW - North America
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043187580&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Irradiation of food and packaging: recent developments.
AU - Komolprasert, V.
AU - Morehouse, K. M.
A2 - Komolprasert, V.
A2 - Morehouse, K. M.
T2 - Irradiation of food and packaging: recent developments
T3 - ACS Symposium Series No.875
Y1 - 2004///
CY - Washington; USA
PB - American Chemical Society
SN - 0841238693
AD - Komolprasert, V.: Division of Food Processing and Packaging, Office of Plant Dairy Foods and Beverages, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20053000405. Publication Type: Book. Note: ACS Symposium Series No.875 Language: English. Number of References: many ref.
N2 - Updates on active research on irradiated foods and irradiated packaging materials are presented, as well as discussions on the effects of the ionizing radiation on food and packaging materials, quoting results from studies as recent as 2002. The main focus of the discussions is on the science of food irradiation and the packaging of irradiated foods; however, other aspects as consumer acceptance, regulatory requirements and detection methods, are also briefly discussed in some chapters.
KW - food processing
KW - food safety
KW - food sciences
KW - food technology
KW - ionizing radiation
KW - irradiation
KW - packaging materials
KW - Processing Equipment and Technology (NN600)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000405&site=ehost-live&scope=site
UR - email: Vanee.Komolprasert@cfsan.fda.gov\Kim.Morehouse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effects of ionizing radiation on food contact materials.
AU - McNeal, T. P.
AU - Komolprasert, V.
AU - Buchalla, R.
AU - Olivo, C.
AU - Begley, T. H.
A2 - Komolprasert, V.
A2 - Morehouse, K. M.
T2 - Irradiation of food and packaging: recent developments
T3 - ACS Symposium Series No.875
Y1 - 2004///
CY - Washington; USA
PB - American Chemical Society
SN - 0841238693
AD - McNeal, T. P.: Division of Chemistry Research and Environmental Review, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20053000415. Publication Type: Book chapter. Note: ACS Symposium Series No.875 Language: English. Number of References: 23 ref. Registry Number: 9002-88-4.
N2 - FDA's Office of Food Additive Safety is responsible for the evaluation of food additive petitions and pre-market notifications requesting approval of new food contact materials for irradiation. Our lab supports that review process by conducting research to identify and quantify the products formed in food contact polymers after exposure to ionizing radiation and then determining whether any of these compounds migrate into food. A major objective of this research is to assist in the development of guidance to manufacturers seeking FDA approval to irradiate their products. Different polyesters, polyamides, a high-density polyethylene, and an ethylene vinyl alcohol copolymer were evaluated before and after exposure to different levels of gamma and electron-beam radiation. Volatile chemicals were isolated from the test materials using static headspace sampling and analysed by gas chromatography with mass selective detection. Semi-volatile and non-volatile chemicals were extracted from the test materials using a variety of solvents including n-heptane, a fatty food simulating solvent, and the extracts were analysed using high performance liquid chromatography with mass selective detection. The extracts containing semi-volatiles were also analysed by gas chromatography with mass selective detection. Most of the chemicals found are thought to be products of the polymerization process or conversion of the polymer(s) into a finished package, and breakdown products of polymer additives. Although exposure to ionizing radiation increases the concentration of some of these chemicals and decreases the concentration of other chemicals, few of the chemicals determined are thought to be chemicals specifically formed by ionizing radiation. Results of these analyses and data on the migration of some of the chemicals are presented.
KW - food contamination
KW - food processing
KW - food safety
KW - food technology
KW - ionizing radiation
KW - irradiation
KW - packaging materials
KW - polyesters
KW - polyethylene
KW - polymerization
KW - polymers
KW - food contaminants
KW - polythene
KW - Processing Equipment and Technology (NN600)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000415&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Irradiation of food and packaging: an overview.
AU - Morehouse, K. M.
AU - Komolprasert, V.
A2 - Komolprasert, V.
A2 - Morehouse, K. M.
T2 - Irradiation of food and packaging: recent developments
T3 - ACS Symposium Series No.875
Y1 - 2004///
CY - Washington; USA
PB - American Chemical Society
SN - 0841238693
AD - Morehouse, K. M.: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053000406. Publication Type: Book chapter. Note: ACS Symposium Series No.875 Language: English. Number of References: 45 ref.
N2 - Ionizing radiation can extend shelf life and improve the quality and safety of foods. National and international organizations and regulatory agencies have concluded that irradiated food is safe and wholesome. A brief background of the food irradiation issues leading to these conclusions is given. Despite its limited use in the past, use of food irradiation is increasing as consumers are beginning to appreciate the benefits of irradiated food. Interest in the use of food irradiation increased following the 1997 US Food and Drug Administration approval of irradiation for pathogen control in unprocessed red meat and meat products. This approval led to numerous studies on a variety of food irradiation applications. Since food is usually prepackaged prior to irradiation, the possibility of radiolytic products being released from packaging materials into food requires a safety evaluation. Therefore, the use of these packaging materials is subject to regulatory review and approval prior to their use.
KW - food processing
KW - food safety
KW - food technology
KW - irradiation
KW - meat
KW - meat products
KW - packaging
KW - packaging materials
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Processing Equipment and Technology (NN600)
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000406&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Irradiation of prepackaged food: evolution of the U.S. Food and Drug Administration's regulation of the packaging materials.
AU - Paquette, K. E.
A2 - Komolprasert, V.
A2 - Morehouse, K. M.
T2 - Irradiation of food and packaging: recent developments
T3 - ACS Symposium Series No.875
Y1 - 2004///
CY - Washington; USA
PB - American Chemical Society
SN - 0841238693
AD - Paquette, K. E.: Office of Food Additive Safety, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, MS HFS-275, College Park, MD 20740, USA.
N1 - Accession Number: 20053000413. Publication Type: Book chapter. Note: ACS Symposium Series No.875 Language: English. Number of References: 40 ref. Registry Number: 9003-53-6. Subject Subsets: Agricultural Engineering
N2 - The FDA approved the first materials intended for use as packaging for irradiated foods (polyolefin films, polystyrene, cellophane, vinylidene chloride copolymers, and others) in 1964. Several other materials were approved for this use during the next four years. Since then, only one material, ethylene vinyl acetate copolymer, was added to Title 21 of the Code of Federal Regulations, in 1989. The recent interest in irradiating meat to eliminate pathogens such as Escherichia coli O157:H7 has resulted in several industry submissions to the Agency regarding new packaging materials, as well as the radiation sources, intended for use during the irradiation of prepackaged food. A brief history of FDA regulation of packaging materials irradiated in contact with food, including a discussion of human exposures to radiolysis products formed in irradiated polymers, are presented. The evaluation of new packaging materials for irradiated foods is discussed within the context of FDA's Food Contact Substance Notification Program.
KW - food contamination
KW - food processing
KW - food safety
KW - food technology
KW - irradiation
KW - meat
KW - microbial contamination
KW - packaging materials
KW - plastics
KW - polystyrenes
KW - regulations
KW - USA
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia coli
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - food contaminants
KW - rules
KW - United States of America
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Processing Equipment and Technology (NN600)
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053000413&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - U.S.F.D.A. regulatory approach for control of residues of veterinary drugs.
AU - Ellis, R.
T2 - Joint FAO/WHO Technical Workshop on Residues of Veterinary Drugs without ADI/MRL, Bangkok, Thailand, 24-26 August 2004
Y1 - 2004///
CY - Rome; Italy
PB - Food and Agriculture Organization of the United Nations (FAO)
SN - 9251052255
AD - Ellis, R.: Center for Veterinary Medicine, Division of Human Food Safety, Rockville, Maryland, USA.
N1 - Accession Number: 20053065884. Publication Type: Book chapter; Conference paper. Language: English. Subject Subsets: Veterinary Science
KW - animal products
KW - antibiotic residues
KW - consumer protection
KW - control
KW - control programmes
KW - drug residues
KW - food inspection
KW - food safety
KW - government organizations
KW - public health
KW - regulations
KW - toxicology
KW - veterinary products
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal health products
KW - consumer advocacy
KW - control programs
KW - rules
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053065884&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Risk assessment of chemicals at low levels - new concepts.
AU - Greenlees, K. J.
AU - Hooberman, B.
T2 - Joint FAO/WHO Technical Workshop on Residues of Veterinary Drugs without ADI/MRL, Bangkok, Thailand, 24-26 August 2004
Y1 - 2004///
CY - Rome; Italy
PB - Food and Agriculture Organization of the United Nations (FAO)
SN - 9251052255
AD - Greenlees, K. J.: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053065888. Publication Type: Book chapter; Conference paper. Language: English. Number of References: 22 ref. Subject Subsets: Veterinary Science
KW - analytical methods
KW - drug residues
KW - drug toxicity
KW - food safety
KW - public health
KW - risk
KW - risk assessment
KW - toxicology
KW - veterinary products
KW - analytical techniques
KW - animal health products
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053065888&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Fumonisins.
AU - Jackson, L.
AU - Jablonski, J.
A2 - Magan, N.
A2 - Olsen, M.
T2 - Mycotoxins in food: detection and control
Y1 - 2004///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 1855737337
AD - Jackson, L.: Food and Drug Administration, National Center for Food Safety and Technology, 6502 S Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20043209298. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Medical & Veterinary Mycology; Animal Nutrition; Veterinary Science; Public Health; Veterinary Science; Maize; Plant Pathology
N2 - This chapter reviews research in fumonisin contamination both of feeds and food. The occurrence of fumonisin in cereal crops, especially maize is briefly described. The chemical and physical properties of this mycotoxin is discussed. Factors affecting fumonisin production by Fusarium spp. are mentioned. Other topics in this chapter include: toxicological effects of fumonisin; methods of detecting and measuring fumonisin in animal feed and food; and control of fumonisin levels in feed and food.
KW - detection
KW - feeds
KW - food contamination
KW - fumonisins
KW - human diseases
KW - maize
KW - mycotoxicoses
KW - mycotoxins
KW - toxicity
KW - animals
KW - Fusarium
KW - man
KW - Zea mays
KW - eukaryotes
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - corn
KW - feeding stuffs
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - mycotoxin poisoning
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20043209298&site=ehost-live&scope=site
UR - email: Lauren.Jackson@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliterans.
AU - Kullman, G.
AU - Boylstein, R.
AU - Jones, W.
AU - Piacitelli, C.
AU - Pendergrass, S.
AU - Kreiss, K.
T2 - Journal of Occupational and Environmental Hygiene
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2005///
VL - 2
IS - 3
SP - 169
EP - 178
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Kullman, G.: National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA.
N1 - Accession Number: 20073099482. Publication Type: Journal Article. Language: English. Registry Number: 64-19-7, 513-86-0, 431-03-8. Subject Subsets: Public Health
N2 - Eight former workers from a microwave popcorn packaging plant were reported to have severe obstructive lung disease consistent with bronchiolitis obliterans. Investigations into respiratory exposures at this plant were done during August through November of 2000. Samples were collected to assess airborne particulate concentrations, particle size distributions, endotoxins, oxides of nitrogen, organic gases and vapors, and other analytes. Bulk corn and flavouring components were also analysed for endotoxins and culturable bacteria and fungi. Workers in the microwave production areas of the plant were exposed to particulates and a range of organic vapors from flavourings. The particles were comprised largely of salt and oil/grease particles. Respirable dust concentrations (area plus personal) in the microwave mixer job category, the highest job exposure category in the plant, ranged from 0.13 milligrams per cubic meter of air (mg/m3) to a high of 0.77 mg/m3. Endotoxin concentrations were below 60 endotoxin units per cubic meter of air (EU/m3). Qualitative sampling for volatile organic compounds (VOCs) in the air detected over 100 different VOCs in the microwave area. The predominant compounds identified in the microwave mixing room included the ketones diacetyl, methyl ethyl ketone, acetoin, and 2-nonanone, and acetic acid. Diacetyl, the predominant ketone in the plant, was present in concentrations ranging from below detectable limits to 98 parts per million parts air by volume (ppm), with a mean of 8.1 ppm (standard deviation 18.5 ppm). The average ketone concentrations were highest in the microwave mixing room where the 10 area samples had a mean diacetyl concentration of 37.8 ppm (SD 27.6 ppm) and a mean acetoin concentration of 3.9 ppm (SD 4.3 ppm). These data show that workers involved in microwave popcorn packaging can be exposed to a complex mixture of VOCs from flavouring ingredients; animal studies show that diacetyl can cause airway epithelial injury, although the contributions of other specific compound(s) associated with obstructive respiratory disease in these workers is still unresolved.
KW - acetic acid
KW - acetoin
KW - air pollutants
KW - diacetyl
KW - dust
KW - endotoxins
KW - exposure
KW - human diseases
KW - ketones
KW - lungs
KW - occupational hazards
KW - occupational health
KW - particle size
KW - respiratory diseases
KW - volatile compounds
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 2-nonanone
KW - bronchiolitis obliterans
KW - lung diseases
KW - methyl ethyl ketone
KW - volatile constituents
KW - Pollution and Degradation (PP600)
KW - Toxinology (VV820) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099482&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a725592417~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - An assessment of occupational safety and health hazards in selected small businesses manufacturing wood pallets - Part 1. Noise and physical hazards.
AU - Malkin, R.
AU - Hudock, S. D.
AU - Hayden, C.
AU - Lentz, T. J.
AU - Topmiller, J.
AU - Niemeier, R. W.
T2 - Journal of Occupational and Environmental Hygiene
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2005///
VL - 2
IS - 4
SP - D18
EP - D21
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Malkin, R.: Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073099502. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Forest Products
KW - hazards
KW - noise
KW - occupational hazards
KW - occupational health
KW - wood workers
KW - woodworking
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Logging and Wood Processing (KK515)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099502&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a725848337~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide contamination inside farm and nonfarm homes.
AU - Curwin, B. D.
AU - Hein, M. J.
AU - Sanderson, W. T.
AU - Nishioka, M. G.
AU - Reynolds, S. J.
AU - Ward, E. M.
AU - Alavanja, M. C.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2005///
VL - 2
IS - 7
SP - 357
EP - 367
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Curwin, B. D.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073099434. Publication Type: Journal Article. Language: English. Registry Number: 1929-73-3, 2008-39-1, 25168-26-7, 2569-10-9, 3599-58-4, 5742-19-8, 94-11-1, 94-75-7, 94-80-4, 34256-82-1, 15972-60-8, 1912-24-9, 2921-88-2, 38641-94-0, 1071-83-6, 70393-85-0, 51218-45-2. Subject Subsets: Agricultural Entomology; Weeds
N2 - Twenty-five farm (F) households and 25 nonfarm (NF) households in Iowa, USA, were enrolled in a study investigating agricultural pesticide contamination inside homes. Air, surface wipe, and dust samples were collected. Samples from 39 homes (20 F and 19 NF) were analysed for atrazine, metolachlor, acetochlor, alachlor, and chlorpyrifos. Samples from 11 homes (5 F and 6 NF) were analysed for glyphosate and 2,4-D. Greater than 88% of the air and greater than 74% of the wipe samples were below the limit of detection (LOD). Among the air and wipe samples, chlorpyrifos was detected most frequently in homes. In the dust samples, all the pesticides were detected in greater than 50% of the samples except acetochlor and alachlor, which were detected in less than 30% of the samples. Pesticides in dust samples were detected more often in farm homes except 2,4-D, which was detected in 100% of the farm and nonfarm home samples. The average concentration in dust was higher in farm homes versus nonfarm homes for each pesticide. Further analysis of the data was limited to those pesticides with approximately 50% of the dust samples above the LOD. All farms that sprayed a pesticide had higher levels of that pesticide in dust than both farms that did not spray that pesticide and nonfarms; however, only atrazine and metolachlor were significantly higher. The adjusted geometric mean pesticide concentration in dust for farms that sprayed a particular pesticide ranged from 94 to 1300 ng/g compared with 12 to 1000 ng/g for farms that did not spray a particular pesticide, and 2.4 to 320 ng/g for nonfarms. The distributions of the pesticides throughout the various rooms sampled suggest that the strictly agricultural herbicides atrazine and metolachlor are potentially being brought into the home on the farmer's shoes and clothing. These herbicides are not applied in or around the home but they appear to be getting into the home para-occupationally. For agricultural pesticides, take-home exposure may be an important source of home contamination.
KW - 2,4-D
KW - acetochlor
KW - alachlor
KW - atrazine
KW - chlorpyrifos
KW - contaminants
KW - contamination
KW - glyphosate
KW - metolachlor
KW - pesticide residues
KW - toxic substances
KW - Iowa
KW - USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - (2,4-dichlorophenoxy)acetic acid
KW - chlorpyrifos-ethyl
KW - poisons
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pollution and Degradation (PP600)
KW - Rural Health (VV550) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099434&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a714035963~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Test for the integrity of environmental tractor cab filtration systems.
AU - Moyer, E. S.
AU - Heitbrink, W. A.
AU - Jensen, P. A.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2005///
VL - 2
IS - 10
SP - 516
EP - 523
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Moyer, E. S.: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Laboratory Research Branch, Morgantown, West Virginia, USA.
N1 - Accession Number: 20073099453. Publication Type: Journal Article. Language: English. Subject Subsets: Agricultural Engineering; Agricultural Entomology; Public Health
N2 - Cab filtration systems can be used to protect vehicle operators from hazardous air contaminants. In a cab filtration system, a fan draws air through filters and pressurizes the cab with this filtered air. This paper describes the application of a low-cost, optical particle counter to evaluate the performance of tractor cab filtration systems. The tractors were equipped with environmental enclosures to protect the operators from pesticide exposures that occur during air blast spraying in orchards. Prior to testing, all environmental tractor cabs underwent a complete maintenance overhaul followed by a careful inspection by the manufacturer's field representative. As part of this maintenance effort, 13 tractors with cab filtration systems were tested in an enclosure. A Met One model 227B two-channel optical particle counter was used to measure the aerosol concentration outside and inside the cab. Ambient aerosol and/or aerosol generated by burning incense sticks were used to challenge the stationary cab filtration system in an enclosure. The ratio of the outside to inside concentration (Co/Ci) is the exposure reduction attained by the cab system. Alternatively, the inside concentration divided by the outside concentration times 100 (Ci/Co × 100) gives the percentage penetration. All the 13 tractors were tested for leak sites. Leak sites were identified and sealed. This process was repeated until each cab showed an exposure reduction ratio Co/Ci of at least 50 (aerosol penetration into the cab Ci/Co × 100 was less than 2%) at the 0.3-0.5 µm particle size interval.
KW - aerosols
KW - agricultural manpower
KW - cabs
KW - exposure
KW - filtration
KW - leakage
KW - pesticides
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099453&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a725847188~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rhabdomyolysis in patients with West Nile encephalitis and meningitis.
AU - Montgomery, S. P.
AU - Chow, C. C.
AU - Smith, S. W.
AU - Marfin, A. A.
AU - O'Leary, D. R.
AU - Campbell, G. L.
JO - Vector Borne and Zoonotic Diseases
JF - Vector Borne and Zoonotic Diseases
Y1 - 2005///
VL - 5
IS - 3
SP - 252
EP - 257
CY - Larchmont; USA
PB - Mary Ann Liebert, Inc.
SN - 1530-3667
AD - Montgomery, S. P.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Public Health Service, Department of Health and Human Services, Fort Collins, Colorado, USA.
N1 - Accession Number: 20053191118. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9001-15-4. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Since 1999, more than 6,500 cases of West Nile virus neuroinvasive disease (WNND) have been reported in the United States. Patients with WNND can present with muscle weakness that is often assumed to be of neurological origin. During 2002, nearly 3,000 persons with WNV meningitis or encephalitis (or both) were reported in the United States; in suburban Cook County, Illinois, with 244 persons were hospitalized for WNV illnesses. The objective of this investigation was to describe the clinical and epidemiological features of identified cases of WNV neuroinvasive disease and rhabdomyolysis. Public health officials investigated patients hospitalized in Cook County, and identified a subset of WNV neuroinvasive disease patients with elevated creatine kinase levels. Cases were defined as hospitalized persons with a WNV infection, encephalitis or meningitis, and rhabdomyolysis. Retrospective medical record reviews were conducted and data was abstracted with a standardized data collection instrument. Eight patients with West Nile encephalitis and one with West Nile meningitis were identified with rhabdomyolysis. Median age of the nine patients was 70 years (range, 45-85 years), and eight were men. For all nine patients, the peak CK level was documented a median of 2 days after hospitalization (range, 1-24 days). Median CK level during hospitalization for all case-patients was 3,037 IU (range, 1,153-42 113 IU). Six patients had history of recent falls prior to admission. Although the temporal relationship of rhabdomyolysis and neurological WNV illness suggested a common etiology, these patients presented with complex clinical conditions which may have led to development of rhabdomyolysis from other causes. The spectrum of WNV disease requires further investigation to describe this and other clinical conditions associated with WNV infection.
KW - aetiology
KW - creatine kinase
KW - encephalitis
KW - epidemiology
KW - human diseases
KW - rhabdomyolysis
KW - viral diseases
KW - Illinois
KW - USA
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - causal agents
KW - creatine phosphokinase
KW - encephalomyelitis
KW - etiology
KW - United States of America
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053191118&site=ehost-live&scope=site
UR - email: SMontgomery@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of interference to conventional and real-time PCR for detection and quantification of fungi in dust.
AU - Keswani, J.
AU - Kashon, M. L.
AU - Chen, B. T.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2005///
VL - 7
IS - 4
SP - 311
EP - 318
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 1464-0325
AD - Keswani, J.: Health Effects Laboratory Division, Exposure Assessment Branch, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S L-3030, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053081077. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Advances in polymerase chain reaction (PCR) have permitted accurate, rapid and quantitative identification of microorganisms in pure cultures regardless of viability or culturability. In this study, a simple sample processing method was investigated for rapid identification and quantification of fungal spores from dust samples using both conventional and real-time PCR. The proposed method was evaluated for susceptibility to interference from environmental dust samples. Stachybotrys chartarum and Aspergillus fumigatus were used as test organisms. The sensitivity of detection in pure culture was 0.1 spore DNA equivalents per PCR reaction corresponding to 20 spores ml-1 in the sample. However, 1 spore DNA equivalent per PCR reaction corresponding to 200 spores ml-1 in the sample was the lowest amount of spores tested without interference in dust samples spiked with spores of either fungal species. The extent of inhibition was calculated using conventional and real-time PCR reactions containing fungal spores, specific primers, specific probes (for real-time PCR) and various amounts of dust. The results indicate that the extent of inhibition by dust on PCR varies with the type and amount of dust, and number of spores. No: interference in the analysis of spiked samples was detected from 0.2 mg ml-1 of four real-life dust samples at p-value >0.05 using 2×104 spores for conventional PCR and 2×105 spores for real-time PCR. However, samples containing >0.2 mg ml-1 real-life dust compromised the PCR assay. These results suggest the potential usefulness of a simple sample processing method in conjunction with PCR for monitoring the fungal content of aerosols collected from indoor environments.
KW - aerosols
KW - analytical methods
KW - detection
KW - fungal spores
KW - house dust
KW - polymerase chain reaction
KW - Aspergillus fumigatus
KW - Stachybotrys
KW - Stachybotrys chartarum
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Hypocreales
KW - Sordariomycetes
KW - Stachybotrys
KW - analytical techniques
KW - fungus
KW - Hyphomycetes
KW - PCR
KW - Stachybotrys atra
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053081077&site=ehost-live&scope=site
UR - email: JKeswani@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transcriptional signatures of normal human mammary epithelial cells in response to benzo[a]pyrene exposure: a comparison of three microarray platforms.
AU - Gwinn, M. R.
AU - Keshava, C.
AU - Olivero, O. A.
AU - Humsi, J. A.
AU - Poirier, M. C.
AU - Weston, A.
JO - OMICS A Journal of Integrative Biology
JF - OMICS A Journal of Integrative Biology
Y1 - 2005///
VL - 9
IS - 4
SP - 334
EP - 350
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1536-2310
AD - Gwinn, M. R.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
N1 - Accession Number: 20083106317. Publication Type: Journal Article. Language: English. Registry Number: 63231-63-0. Subject Subsets: Dairy Science
N2 - Microarrays are used to study gene expression in a variety of biological systems. A number of different platforms have been developed, but few studies exist that have directly compared the performance of one platform with another. The goal of this study was to determine array variation by analyzing the same RNA samples with three different array platforms. Using gene expression responses to benzo[a]pyrene exposure in normal human mammary epithelial cells (NHMECs), we compared the results of gene expression profiling using three microarray platforms: photolithographic oligonucleotide arrays (Affymetrix), spotted oligonucleotide arrays (Amersham), and spotted cDNA arrays (NCI). While most previous reports comparing microarrays have analysed pre-existing data from different platforms, this comparison study used the same sample assayed on all three platforms, allowing for analysis of variation from each array platform. In general, poor correlation was found with corresponding measurements from each platform. Each platform yielded different gene expression profiles, suggesting that while microarray analysis is a useful discovery tool, further validation is needed to extrapolate results for broad use of the data. Also, microarray variability needs to be taken into consideration, not only in the data analysis but also in specific probe selection for each array type.
KW - analysis
KW - cells
KW - complementary DNA
KW - cytotoxicity
KW - gene expression
KW - research
KW - RNA
KW - toxicology
KW - variation
KW - cDNA
KW - pyrenes
KW - ribonucleic acid
KW - studies
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083106317&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/abs/10.1089/omi.2005.9.334
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis mortality by industry in the United States, 1990-1999.
AU - Bang, K. M.
AU - Weissman, D. N.
AU - Wood, J. M.
AU - Attfield, M. D.
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
Y1 - 2005///
VL - 9
IS - 4
SP - 437
EP - 442
CY - Paris; France
PB - International Union Against Tuberculosis and Lung Disease (IUATLD)
SN - 1027-3719
AD - Bang, K. M.: Division of Respiratory Disease Studies, Room H-G900.2, National Institute for Occupational Safety and Health, US Department of Health and Human Services, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053073770. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 27 ref. Subject Subsets: Public Health
N2 - OBJECTIVE: To identify occupations and industries with elevated respiratory tuberculosis (TB) mortality in the United States for the period 1990-1999, we used National Center for Health Statistics multiple-cause-of-death data, restricted to certain states for which information on decedents' usual industry and occupational information was available and limited to US residents aged ≥15 years. DESIGN: A total of 7686 deaths between 1990 and 1999 were attributed to respiratory TB. Proportionate mortality ratios (PMRs), adjusted for age, sex, and race, were calculated from US census occupation and industry classifications. RESULTS: Industries and occupations involving potential contact with infected cases (e.g., health care workers), those with silica exposure and silicosis (e.g., mining and construction), and those associated with low socio-economic status had significantly elevated TB mortality. CONCLUSIONS: Overall, the pattern of findings echoes that described in various prior reports, which indicates that the potential for exposure and disease development still persists among certain worker groups. The findings should be useful in guiding occupationally targeted TB prevention programs.
KW - bacterial diseases
KW - epidemiology
KW - health care workers
KW - human diseases
KW - miners
KW - mortality
KW - occupational hazards
KW - socioeconomic status
KW - tuberculosis
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - death rate
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053073770&site=ehost-live&scope=site
UR - http://www.ingenta.com
UR - email: kmb2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Injuries to youth living on U.S. farms in 2001 with comparison to 1998.
AU - Hendricks, K. J.
AU - Layne, L. A.
AU - Goldcamp, E. M.
AU - Myers, J. R.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2005///
VL - 10
IS - 4
SP - 19
EP - 26
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - Hendricks, K. J.: National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, 1095 Willowdale Road, M/S 1808, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063155645. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - To obtain sustained injury surveillance data for youth on farms, the National Institute for Occupational Safety and Health developed the Childhood Agricultural Injury Survey (CAIS) in collaboration with the U.S. Department of Agriculture. The first CAIS collected data for youth less than 20 years in 1998 through a regionally stratified telephone survey of 50 000 U.S. farm households; a second CAIS for 2001 was conducted using the same methodology. In 2001, there were approximately 1.2 million youth living on U.S. farms. These youth suffered an estimated 19 397 injuries (15.7/1,000 household youth). Approximately 60% (11 571) of the household youth injuries were to males. For all household youth, 10-15 year olds experienced the most injuries (49%, 9,486). In addition to providing estimates of demographics, injuries, and injury rates for household youth from the 2001 CAIS, this article provides a comparison to results from the 1998 CAIS. The number of household youth injuries on farms from 1998 to 2001 decreased by almost 30% (27 321 vs. 19 397). The results of this study show an overall decrease in the injury rate for youth living on the farm from 1998 to 2001 (18.8/1,000 household youth vs. 15.7/1,000 household youth). However, there was a considerable increase in the number of injuries to household females less than 20 years of age during this same time period. There was also an increase in the number of all terrain vehicle (ATV) and horse-related injuries. Continued surveillance is needed to assess if these are significant trends or the result of changing farm demographics.
KW - age differences
KW - age groups
KW - boys
KW - children
KW - disease surveys
KW - epidemiology
KW - farms
KW - girls
KW - health hazards
KW - household surveys
KW - households
KW - trauma
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease surveillance
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063155645&site=ehost-live&scope=site
UR - http://www.haworthpress.com/web/JA/
UR - email: khendricks@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of West Nile viral replication and maturation in peripheral neurons in culture.
AU - Hunsperger, E.
AU - Roehrig, J. T.
JO - Journal of Neurovirology
JF - Journal of Neurovirology
Y1 - 2005///
VL - 11
IS - 1
SP - 11
EP - 22
CY - New York; USA
PB - Informa Healthcare
SN - 1355-0284
AD - Hunsperger, E.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Fort Collins, Colorado, USA.
N1 - Accession Number: 20083025948. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - The North American West Nile virus (WNV), New York 1999 strain, appears to be highly neurotropic, and its neuroinvasiveness is an important aspect of human disease. The authors have developed an in vitro model to study WNV replication and protein processing in neurons. They compared WNV infection of the dorsal root ganglion (DRG) neurons (sensory neurons) and PC-12 cells (sympathetic neurons) to WNV infection of the mosquito cell line, C6/36, and Vero cells. WNV infection of both neuronal cell types and C6/36 cells was not cytopathic up to 30 days post infection, and continual viral shedding was observed during this period. However, WNV infection of Vero cells was lytic. Interestingly, WNV infection of neurons was not efficient, requiring a high multiplicity of infection of ≥10. Indirect immunofluorescence assays using normal and confocal microscopy with flavivirus-reactive antibodies and WNV-infected neurons demonstrated viral antigen mostly associated with the plasma membrane and in the neurite processes. Treatment of WNV-infected C6/36, PC-12, or DRG cells with brefeldin A (BFA; a trans-Golgi inhibitor) or nocadazole (a β-tubulin inhibitor) had little effect on viral maturation and secretion. Treatment of WNV-infected Vero cells with BFA resulted in a 1000-fold decrease in viral titer, but nocodazole had no effect. Our studies suggest that even though PC-12 and DRG neurons are mammalian cells, viral protein processing and maturation in these cells more closely resembles replication in C6/36 insect cells than in mammalian Vero cells.
KW - cell invasion
KW - in vitro
KW - neurons
KW - pathogenesis
KW - viral antigens
KW - viral load
KW - viral replication
KW - West Nile virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - nerve cells
KW - neurones
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083025948&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a725258820~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The minimum number of clones necessary to sequence in order to obtain the maximum information about hepatitis C virus quasispecies: a comparison of subjects with and without liver cancer.
AU - Gao, G.
AU - Stuver, S. O.
AU - Okayama, A.
AU - Tsubouchi, H.
AU - Mueller, N. E.
AU - Tabor, E.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005///
VL - 12
IS - 1
SP - 46
EP - 50
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1352-0504
AD - Gao, G.: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20852-1448, USA.
N1 - Accession Number: 20053015067. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 63231-63-0. Subject Subsets: Public Health
N2 - Most studies of hepatitis C virus (HCV) quasispecies have reported the results of sequencing only three to five clones per sample. The possibility that sequencing so few clones might not provide a representative picture of the quasispecies present in a sample has never been evaluated. The present study was conducted to evaluate whether sequencing greater numbers of clones results in better information about the HCV quasispecies number and distribution, and to compare the HCV quasispecies in liver cancer cases and controls. RNA was extracted from serial serum samples from six subjects with HCV-associated liver cancer and 11 age- and sex-matched HCV-infected controls without liver cancer. The hypervariable region 1 (HVR1) of the HCV genome was amplified, cloned, and sequenced. For further studies of 12 serum samples from two liver cancer cases and two matched controls, successive groups of 10 additional clones were sequenced up to a total of 50 clones per serum sample. When only 10 clones were sequenced from each specimen, no consistent differences were seen between the number of HCV quasispecies in the six liver cancer cases and the 11 controls. However, sequencing 40 clones from each of 12 samples from two liver cancer cases and two controls revealed a greater number of quasispecies in liver cancer cases than in controls. Testing an additional 10 clones (50 clones per sample) did not significantly increase the number of quasispecies detected.
KW - blood serum
KW - clones
KW - genetic diversity
KW - genomes
KW - hepatitis C
KW - human diseases
KW - liver
KW - liver cancer
KW - liver diseases
KW - molecular epidemiology
KW - neoplasms
KW - nucleotide sequences
KW - RNA
KW - viral diseases
KW - viral hepatitis
KW - Japan
KW - hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - cancers
KW - DNA sequences
KW - ribonucleic acid
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053015067&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/rd.asp?code=JVH&goto=journal
UR - email: tabor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HBsAg-negative hepatitis B virus infections in hepatitis C virus-associated hepatocellular carcinoma.
AU - Momosaki, S.
AU - Nakashima, Y.
AU - Kojiro, M.
AU - Tabor, E.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005///
VL - 12
IS - 3
SP - 325
EP - 329
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1352-0504
AD - Momosaki, S.: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20053076901. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - This study was conducted to evaluate reports that hepatitis B virus (HBV) DNA sequences can be found in the serum and/or tumour tissue from some hepatocellular carcinoma (HCC) patients who have no detectable hepatitis B surface antigen (HBsAg) in their sera. Such HBV infections would be highly atypical, because prospective studies have shown a clear succession of specific serologic markers during and after most HBV infections. As most HBsAg-negative HCC patients in Japan have hepatitis C virus (HCV) infections, the present study was conducted to determine whether some of these patients actually have unrecognized HBV infections. Thirty newly diagnosed HCC patients from Kurume, Japan, with antibody to the hepatitis C virus (anti-HCV) were studied. None of the 30 had HBsAg detectable in their serum. Of 22 for whom test results for antibodies to the hepatitis B core antigen (anti-HBc) and antibodies to HBsAg (anti-HBs) were available, 14 (64%) had anti-HBc and anti-HBs, four (18%) had anti-HBc alone, and four (18%) had no HBV markers. Nested polymerase chain reaction was used to detect the HBV surface (S), core (C), polymerase (P) and core promoter gene sequences in the HCC tissues and in the adjacent nontumorous liver tissues. HBV DNA was detected in HCC and/or adjacent nontumorous liver in 22 of 30 (73%) patients [detected in both HCC and nontumorous liver in 19/30 patients (63%)]. Among the 22 patients with detectable HBV DNA, more than one HBV gene was detected in 10 (46%). Among the four patients whose sera were negative for all HBV markers, three had HBV DNA in either HCC and nontumorous liver (two cases) or only in the nontumorous liver (one case); HBV DNA could not be detected in tissues from the fourth patient. In 18 of 21 (86%) patients with detectable HBV core promoter sequences, mutations at both nucleotides 1762 (A-GT) and 1764 (G-A) in the core promoter region were found. No deletions were detected in the core promoter gene region of the type reported to be associated with some cases of HBsAg-negative HBV infection. Thus, HBV DNA was detectable in 22 (73%) HBsAg-negative, anti-HCV-positive HCCs, including three (10%) who were also negative for anti-HBc and anti-HBs. HBV mutations at both nucleotides 1762 (A-GT) and 1764 (G-A) in the core promoter region were found in the majority of cases, mutations that have previously been reported in HBV that is integrated in HCC DNA. In serologic surveys to determine etiologic associations of HCC, patients such as those in this study would have been incorrectly designated as having 'HCV-associated HCC,' whereas the data in this study suggest that HBV could have played a role in the development of their HCCs.
KW - DNA
KW - hepatitis B
KW - hepatitis C
KW - human diseases
KW - liver
KW - liver cancer
KW - liver diseases
KW - mixed infections
KW - molecular genetics
KW - mutants
KW - mutations
KW - neoplasms
KW - surface antigens
KW - viral antigens
KW - Japan
KW - hepatitis B virus
KW - hepatitis C virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - biochemical genetics
KW - cancers
KW - deoxyribonucleic acid
KW - multiple infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053076901&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jvh
UR - email: tabor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - SEN virus infection in patients with hepatocellular carcinoma.
AU - Momosaki, S.
AU - Umemura, T.
AU - Scudamore, C. H.
AU - Kojiro, M.
AU - Alter, H. J.
AU - Tabor, E.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005///
VL - 12
IS - 4
SP - 435
EP - 438
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1352-0504
AD - Momosaki, S.: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20053117218. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - Although most cases of hepatocellular carcinoma (HCC) are associated with either the hepatitis B or C viruses (HBV, HCV), about 10-20% of HCCs occur in patients with chronic hepatitis that is aetiologically undefined. The aim of the present study was to determine the prevalence of the transfusion-transmitted SEN virus (SEN-V) in patients with HCC, including those patients who do not otherwise appear to be infected with HBV or HCV. Fragments of SEN-V subtypes D and H were amplified separately by PCR from the sera of 50 patients with HCC (31 from Canada and 19 from Japan) as well as from HCC and adjacent nontumourous liver tissues from eight of the Canadian patients. SEN-V DNA was found in the serum of 10 of 31 (32%) Canadian patients and eight of 19 (42%) Japanese patients [overall, 18 of 50 (36%) HCC patients]. SEN-V DNA was detected in the serum of 10 of 23 (43%) HCC patients with antibody to HCV (anti-HCV), six of 11 (55%) with hepatitis B surface antigen (HBsAg), and two of 16 (12%) without detectable anti-HCV or HBsAg. Twenty-three HCC patients in this study had 'silent HBV,' characterized by the detection of HBV DNA in the absence of HBsAg; eight of these (35%) also had SEN-V infections. SEN-V DNA was detected in HCC patients most typically in those with coexistent HBV or HCV infection. SEN-V was found in only one of seven HCC patients without HBV (without HBsAg or HBV DNA) or HCV and thus does not appear to be an important cause of 'cryptogenic' HCC.
KW - antibodies
KW - blood serum
KW - disease prevalence
KW - DNA
KW - epidemiology
KW - hepatitis B
KW - hepatitis C
KW - hepatocellular carcinoma
KW - human diseases
KW - liver
KW - liver cancer
KW - liver diseases
KW - neoplasms
KW - seroprevalence
KW - surface antigens
KW - viral diseases
KW - viral hepatitis
KW - Canada
KW - Japan
KW - Circoviridae
KW - hepatitis B virus
KW - hepatitis C virus
KW - man
KW - ssDNA viruses
KW - DNA viruses
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East Asia
KW - Asia
KW - cancers
KW - deoxyribonucleic acid
KW - hepatitis B surface antigens
KW - SEN virus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053117218&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jvh
UR - email: tabor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Duplex microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin M antibodies.
AU - Johnson, A. J.
AU - Noga, A. J.
AU - Kosoy, O.
AU - Lanciotti, R. S.
AU - Johnson, A. A.
AU - Biggerstaff, B. J.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2005///
VL - 12
IS - 5
SP - 566
EP - 574
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Johnson, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063028388. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - West Nile (WN) virus was introduced into the United States in 1999, when the first human cases of WN fever and encephalitis appeared in New York City. From there, the virus has spread throughout North America, in some areas cocirculating with the related flavivirus St. Louis encephalitis (SLE) virus. Public health laboratories currently use an immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) as a primary test for human serodiagnosis, followed by a confirmatory plaque-reduction neutralization test (PRNT). The MAC-ELISAs take 2 days to perform; therefore there is a need for a more rapid test. This report describes a duplex microsphere-based immunoassay (MIA) that shortens the test processing time to about 4.5 h. The assay employs two sets of microspheres coupled to a single flavivirus group-reactive antibody, which are used to capture the WN and SLE viral antigens independently. Immunoglobulin G-depleted serum is concurrently assayed for IgM antibodies to each of the viral antigens. The results are standardized and classified by using quadratic discriminant analysis so that a single result, anti-WN IgM-positive, anti-SLE IgM-positive, negative, or nonspecific, can be determined. The duplex MIA results compared favorably to those of the plaque-reduction neutralization test and MAC-ELISA. The assay proved to be reproducible, produced accurate classifications as to the infecting virus, and was specific.
KW - antibodies
KW - antibody testing
KW - diagnostic techniques
KW - human diseases
KW - IgM
KW - immunoassay
KW - immunodiagnosis
KW - rapid methods
KW - St Louis encephalitis
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antibody detection
KW - antibody tests
KW - serological diagnosis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063028388&site=ehost-live&scope=site
UR - http://cvi.asm.org/cgi/content/abstract/12/5/566
UR - email: ajj1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The advances on detection methods of cape jasmine fruit (Gardenia jasminoides) and geniposide in the preparations containing G. jasminoides.
AU - Ma Teng
AU - Han Mincai
AU - Su Jian
AU - Wang Baoqin
JO - Chinese Journal of Information on Traditional Chinese Medicine
JF - Chinese Journal of Information on Traditional Chinese Medicine
Y1 - 2005///
VL - 12
IS - 7
SP - 49
EP - 51
CY - Beijing; China
PB - Chinese Journal of Information on Traditional Chinese Medicine
SN - 1005-5304
AD - Ma Teng: Food and Drug Administration of Hebei Province, Shijiazhuang 050057, China.
N1 - Accession Number: 20063241053. Publication Type: Journal Article. Language: Chinese. Number of References: 34 ref. Subject Subsets: Tropical Diseases; Aromatic & Medicinal Plants
N2 - Cape jasmine fruit (Gardenia jasminoides) has been widely used in Traditional Chinese Medicine and geniposide is a major effective compound. High performance liquid chromatography (HPLC) was used in the quantification of geniposide. Various mobile phase had been tested, acetonitrile ¿C water (10:90) and 0.1% triethylamine (0.1% phosphoric acid water solution) ¿C acetonitrile (9:1) all showed good separation of geniposide. Thin layer chromatography ¿C scanning had also been applied. It was found that different silica gel could affect the accuracy of quantification.
KW - iridoids
KW - medicine
KW - phytochemicals
KW - separation
KW - traditional Chinese medicine
KW - traditional medicine
KW - traditional medicines
KW - Gardenia
KW - Gardenia jasminoides
KW - Jasminum
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Gardenia
KW - Oleaceae
KW - Scrophulariales
KW - folk medicine
KW - geniposide
KW - medical sciences
KW - Oleales
KW - separating
KW - TCM
KW - Plant Composition (FF040)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Health Services (UU350)
KW - Pesticides and Drugs (General) (HH400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063241053&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of an improved method for the recombinant K39 enzyme-linked immunosorbent assay to detect visceral leishmaniasis disease and infection in Bangladesh.
AU - Kurkjian, K. M.
AU - Vaz, L. E.
AU - Haque, R.
AU - Cetre-Sossah, C.
AU - Akhter, S.
AU - Roy, S.
AU - Steurer, F.
AU - Amann, J.
AU - Ali, M.
AU - Chowdhury, R.
AU - Wagatsuma, Y.
AU - Williamson, J.
AU - Crawford, S.
AU - Breiman, R. F.
AU - Maguire, J. H.
AU - Bern, C.
AU - Secor, W. E.
JO - Clinical and Diagnostic Laboratory Immunology
JF - Clinical and Diagnostic Laboratory Immunology
Y1 - 2005///
VL - 12
IS - 12
SP - 1410
EP - 1415
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1071-412X
AD - Kurkjian, K. M.: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Division of Parasitic Diseases, Branch of Parasitic Diseases, Public Health Service, Department of Health and Human Services, 4770 Buford Highway NE, Atlanta, GA 30341, USA.
N1 - Accession Number: 20063009018. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - Several serology-based immunoassays are used to diagnose visceral leishmaniasis (VL), a chronic protozoan parasitic disease caused by the Leishmania donovani complex. These tests are primarily designed to diagnose the most severe clinical form of VL, known as kala-azar. However, leishmanial infection is frequently asymptomatic and may manifest only as a positive serologic response or positive leishmanin skin test. We modified a previously described enzyme-linked immunosorbent assay (ELISA) that detects patient antibodies reactive with the recombinant Leishmania protein K39 (rK39) to confirm suspected kala-azar and to detect asymptomatic infection in a community study in Bangladesh. With the inclusion of a standard curve on each ELISA plate, the rK39 ELISA was more repeatable (kappa coefficient of agreement=0.970) and more reliable compared to the original method (kappa=0.587, P<0.001). The cutoff point for a positive antibody response was chosen based on the 99th percentile of the ELISA distribution for the negative-control sera. However, we found that sera from all patients with active kala-azar yielded values more than twice the magnitude of this cutoff. Using receiver-operator characteristic curves, we determined a second cutoff value predictive of kala-azar. Using these criteria, the sensitivity and specificity of the modified ELISA for kala-azar were 97.0% and 98.9%, respectively, for sera from our study population. We hypothesize that individuals with antibody levels greater than the 99th percentile of the negative controls but less than the cutoff point for kala-azar have asymptomatic leishmanial infections.
KW - clinical aspects
KW - diagnostic techniques
KW - ELISA
KW - human diseases
KW - immunodiagnosis
KW - kala azar
KW - skin tests
KW - Bangladesh
KW - Leishmania donovani
KW - man
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Commonwealth of Nations
KW - Least Developed Countries
KW - Developing Countries
KW - South Asia
KW - Asia
KW - clinical picture
KW - enzyme linked immunosorbent assay
KW - intradermal tests
KW - serological diagnosis
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063009018&site=ehost-live&scope=site
UR - email: WSecor@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Multicentre trials: a US regulatory perspective.
AU - Anello, C.
AU - O'Neill, R. T.
AU - Dubey, S.
A2 - Jones, B.
T2 - Statistical Methods in Medical Research
T3 - Special issue: Multicentre trials
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2005///
VL - 14
IS - 3
SP - 303
EP - 318
CY - London; UK
PB - Arnold
SN - 0962-2802
AD - Anello, C.: Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063044427. Publication Type: Journal issue. Note: Special issue: Multicentre trials Language: English. Number of References: 27 ref. Registry Number: 37350-58-6. Subject Subsets: Public Health
N2 - Multicentre trials are very common in the field of drug development. In recent years, multicentre trials have taken on a multinational and multiregional aspect. We provide a conceptual framework for the use of multicentre trials in the context of drug development, from the perspective of drug regulation in the United States. In this paper, we review some regulatory history, milestones and standards as they relate to multicentre trials. Special attention is given to the similarities and differences in the approaches to multicentre trials in the following documents; Guideline for the Format and Content of the Clinical and Statistical Sections of New Drug Applications, International Conference on Harmonization, Draft Guideline on Statistical Principles for clinical trials and the Guidance for Industry Providing Clinical Evidence of Effectiveness for Human Drug and Biologic Products. The paper includes a consideration of some of the issues in the analysis of data from multicentre trials.
KW - clinical trials
KW - data analysis
KW - drug development
KW - drug therapy
KW - drugs
KW - experimental design
KW - heart diseases
KW - human diseases
KW - metoprolol
KW - regulations
KW - reviews
KW - statistical analysis
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - coronary diseases
KW - medicines
KW - pharmaceuticals
KW - plot design
KW - rules
KW - statistical methods
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063044427&site=ehost-live&scope=site
UR - email: charles.anello@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regarding "increase in breast cancer incidence in middle-aged women during the 1990s".
AU - Ward, E.
AU - Jemal, A.
AU - Thun, M.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2005///
VL - 15
IS - 6
SP - 424
EP - 425
CY - New York; USA
PB - Elsevier
SN - 1047-2797
AD - Ward, E.: National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20053140336. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Public Health
N2 - The incidence rates and annual percent change in incidence rates of breast cancer among non-Hispanic white middle-aged women (aged 45-64 years) in Marin County and in other 4 counties in San Francisco Bay area (SFBA), California, USA, during 1992-99 were calculated using projected populations from the 1990 census, and during 1992-2000 using interpolated population estimates from the 1990 and 2000 censuses. Data showed that the incidence of breast cancer in Marin County based on projected population estimates was increasing significantly at an average rate of 3.7% per year during 1992-99, with no significant increase in other age groups or other SFBA counties. However, based on interpolated population estimates, the incidence rate of breast cancer was stable in Marin County during 1992-2000, with an average annual change of 0.3%. The rapid increase in breast cancer incidence rate based on projected population estimates using the 1990 census was due to underestimation of population growth. Based on interpolation between the 1990 and 2000 censuses, the number of non-Hispanic white middle-aged women increased by 29% from 1992 to 1999, not by 10% as was projected from the 1990 census. This study illustrates the pitfalls of interpreting temporal trends in small geographical areas and the importance of developing better methods to identify demographic shifts in evaluating local cancer rates.
KW - breast
KW - breast cancer
KW - censuses
KW - disease incidence
KW - epidemiology
KW - estimates
KW - human diseases
KW - middle-aged adults
KW - neoplasms
KW - temporal variation
KW - trends
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breasts
KW - cancers
KW - estimations
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053140336&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10472797
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The production and characterization of monoclonal antibodies to the fungus Aspergillus versicolor.
AU - Schmechel, D.
AU - Simpson, J. P.
AU - Lewis, D. M.
JO - Indoor Air
JF - Indoor Air
Y1 - 2005///
VL - 15
IS - S9
SP - 11
EP - 19
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0905-6947
AD - Schmechel, D.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M/S H-4020 Morgantown, WV 26505, USA.
N1 - Accession Number: 20053104091. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 20 ref. Registry Number: 308067-58-5. Subject Subsets: Weeds; Medical & Veterinary Mycology
N2 - Fungal exposure measurements in indoor environments require accurate and precise monitoring methods. Such techniques may be based on monoclonal antibodies (Mabs) and enzyme-linked immunosorbent assays (ELISA). Here we report the cross-reactivity patterns of Mabs produced against Aspergillus versicolor spores. BALB/c mice were immunized with the particulate fraction of homogenized spores and 46 Mabs (35 IgM, 9 IgG3 and 2 IgG1) were produced and tested for cross-reactivity against 55 fungal species. None of the Mabs was species-specific for A. versicolor. Several Mabs strongly cross-reacted with most Aspergillus, Penicillium and Eurotium species and some Mabs also cross-reacted with Paecilomyces variotii and several Cladosporium and Stachybotrys species. Our results show that antibody responses in mice against spores of A. versicolor are dominated by highly cross-reactive antibodies of the IgM isotype. The widespread cross-reactivity suggests that the specificity of antibodies to be used for the detection of fungi in environmental samples need to be thoroughly characterized to avoid ambiguities in the interpretation of monitoring results. Furthermore, accurate estimates of spore concentrations may require the application of species-specific Mabs to avoid bias in result interpretation because of the differential reactivity of cross-reactive Mabs with different fungi.
KW - animal models
KW - cross reaction
KW - fungal antigens
KW - fungal spores
KW - IgG
KW - IgM
KW - immune response
KW - laboratory animals
KW - monoclonal antibodies
KW - Aspergillus
KW - Aspergillus versicolor
KW - Cladosporium
KW - Eurotium
KW - mice
KW - Paecilomyces variotii
KW - Penicillium
KW - Stachybotrys
KW - Trichocomaceae
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Aspergillus
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Paecilomyces
KW - Hypocreales
KW - Sordariomycetes
KW - fungus
KW - Hyphomycetes
KW - immunity reactions
KW - immunological reactions
KW - Weeds and Noxious Plants (FF500)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053104091&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=ina
UR - email: dschmechel@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of surrogate markers of biological agents in air and settled dust samples to evaluate a water-damaged hospital.
AU - Rao, C. Y.
AU - Cox-Ganser, J. M.
AU - Chew, G. L.
AU - Doekes, G.
AU - White, S.
JO - Indoor Air
JF - Indoor Air
Y1 - 2005///
VL - 15
IS - S9
SP - 89
EP - 97
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0905-6947
AD - Rao, C. Y.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Suite 2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053104100. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 43 ref. Registry Number: 9041-22-9, 57-87-4. Subject Subsets: Weeds; Medical & Veterinary Mycology
N2 - An environmental survey was conducted in August 2000 in 2 hospital buildings in Montana, USA, one of which had historical water incursion on the top floors and higher prevalence of reported respiratory symptoms that improved when the occupants were away from work. We measured culturable fungi and bacteria, fungal spores, endotoxin and sub-micron particles in air; and culturable fungi and bacteria, endotoxin, markers of fungi (extracellular polysaccharides specific for Penicillium/Aspergillus, ergosterol and β(1->3)glucans) and cat allergen in chair and floor dusts. For the analytes measured in air, the correlation coefficients ranged from 0.43 to 0.78 (P<0.05). In chair dust, β(1->3)glucan concentrations correlated with culturable fungi and ergosterol concentrations. Sub-micron particles and markers of microbiological agents, but not culturable microbiological agents, were significantly positively associated with the building that had both historical water damage and higher prevalence of reported respiratory symptoms. Chair dust measurements tended to be higher in the non-complaint building. These results suggest that air and floor dust measurements of marker compounds may be better indicators of current health risk in a water-damaged environment than chair dust measurements or measurements of culturable fungi or bacteria in air or settled dust.
KW - air
KW - air spora
KW - allergens
KW - beta-glucan
KW - dust
KW - endotoxins
KW - ergosterol
KW - floors
KW - fungal spores
KW - hospitals
KW - microbial contamination
KW - particles
KW - polysaccharides
KW - respiratory diseases
KW - surrogate markers
KW - surveys
KW - Montana
KW - USA
KW - Aspergillus
KW - bacteria
KW - cats
KW - fungi
KW - Penicillium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - prokaryotes
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - bacterium
KW - complex carbohydrates
KW - flooring
KW - fungus
KW - Hyphomycetes
KW - lung diseases
KW - United States of America
KW - Weeds and Noxious Plants (FF500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053104100&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=ina
UR - email: cnr3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Caliciviruses (Norovirus) in the hospital environment.
AU - Szücs, G.
AU - Matson, D. O.
JO - Reviews in Medical Microbiology
JF - Reviews in Medical Microbiology
Y1 - 2005///
VL - 16
IS - 2
SP - 39
EP - 47
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0954-139X
AD - Szücs, G.: Regional Laboratory of Virology, National Reference Laboratory for Gastroenteritis Viruses, ÁNTSZ Baranya County, Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20053078504. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Subject Subsets: Public Health
N2 - Norovirus outbreaks are an increasing public health problem in hospitals. Of all outbreaks of gastroenteritis in hospitals, 35-63% are attributed to Noroviruses. Epidemic curves of outbreaks exhibit primary, secondary, and sometimes tertiary cases. Person-to-person transmission by direct contact, through aerosol or contaminated surfaces, or through food handled by infected food-handlers, are the main transmission routes of Norovirus infection. Most frequently affected are the medical, paediatric, orthopaedic, and geriatric wards, including psychogeriatric hospitals and other health-care facilities for the elderly. The risk of being affected by an outbreak is significantly greater on wards that have reported outbreaks previously. The attack rate is around 50% for patients (~25% for the staff) and the infective dose is as small as 1-10 virus particles. The very short incubation time (12-48 h) demands rapid intervention. Although Norovirus illness is short-lived and usually self-limiting, the infections can lead to ward and sometimes hospital closures, with a major impact on patient care and, potentially, hospital finances. The recent development of novel molecular methods for detecting and differentiating Norovirus has allowed diagnosis of the virus with increased sensitivity and specificity. Genotyping of strains is an important tool for uncovering transmission routes and the appearance of epidemic strains. When an outbreak is suspected, infection control measures must be implemented immediately to limit a Norovirus outbreak. Furthermore, an outbreak surveillance system must be maintained for monitoring local and national trends of Norovirus outbreaks.
KW - antiviral agents
KW - clinical aspects
KW - diagnosis
KW - disease control
KW - disease transmission
KW - drug therapy
KW - epidemiology
KW - genes
KW - genomes
KW - hospitals
KW - human diseases
KW - immune response
KW - molecular genetics
KW - nosocomial infections
KW - outbreaks
KW - pathogenesis
KW - reviews
KW - viral diseases
KW - Caliciviridae
KW - man
KW - Norovirus
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - biochemical genetics
KW - chemotherapy
KW - clinical picture
KW - hospital infections
KW - immunity reactions
KW - immunological reactions
KW - viral infections
KW - winter vomiting disease
KW - winter vomiting virus
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053078504&site=ehost-live&scope=site
UR - email: szucsgy@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC-PAD-ESI/MS.
AU - Wei Feng
AU - Cheng XianLong
AU - Ma LinYun
AU - Jin, W. T.
AU - Schaneberg, B. T.
AU - Khan, I. A.
AU - Lin RuiChao
JO - Phytochemical Analysis
JF - Phytochemical Analysis
Y1 - 2005///
VL - 16
IS - 3
SP - 222
EP - 230
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0958-0344
AD - Wei Feng: Division of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, 2 Tiantan Xili, Beijing, 100050, China.
N1 - Accession Number: 20053144228. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Ornamnental Horticulture
N2 - An HPLC-UV-MS method for the analysis of aristolochic acids A, B, C and D, 7-OH-aristolochic acid A, and aristolic acid in a number of plant materials and their commercial products has been developed. HPLC with photodiode array detection and electrospray ionization-MS in the selected ion monitoring mode allowed the identification of the target compounds and increased the selectivity of complex analyses such as those associated with multi-botanical preparations. The method was used to analyse 10 plant samples (roots of Aristolochia fangchi and Stephania tetrandra, stems of Aristolochia manshuriensis, Clematis armandii and Akebia quinata, herbs of Akebia trifoliata, Aristolochia contorta and Asarum heterotropoides, fruits and roots of Aristolochia contorta) and six commercial products that possibly contained aristolochic acids. The resulting chromatographic profiles of the samples were significantly different from each other, and the method was directly transferred to HPLC-MS, which was used to confirm the presence of the six aristolochic acids mentioned above.
KW - analogues
KW - analytical methods
KW - chemical composition
KW - fruits
KW - herbal drugs
KW - HPLC
KW - mass spectrometry
KW - medicinal plants
KW - plant composition
KW - roots
KW - stems
KW - toxic substances
KW - ultraviolet radiation
KW - China
KW - Akebia
KW - Akebia trifoliata
KW - Aristolochia
KW - Asarum
KW - Clematis
KW - Stephania tetrandra
KW - Lardizabalaceae
KW - Ranunculales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Aristolochiaceae
KW - Aristolochiales
KW - Ranunculaceae
KW - Stephania
KW - Menispermaceae
KW - Akebia
KW - Aristolochia
KW - Asarum
KW - Clematis
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Akebia quinata
KW - analogs
KW - analytical techniques
KW - Aristolochia contorta
KW - Aristolochia fangchi
KW - Aristolochia manshuriensis
KW - Asarum heterotropoides
KW - chemical constituents of plants
KW - Clematis armandii
KW - drug plants
KW - herbal medicines
KW - high performance liquid chromatography
KW - medicinal herbs
KW - officinal plants
KW - People's Republic of China
KW - poisons
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053144228&site=ehost-live&scope=site
UR - email: hograwei@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Unique occupational hazards of Alaska: animal-related injuries.
AU - Mode, N. A.
AU - Hackett, E. J.
AU - Conway, G. A.
JO - Wilderness and Environmental Medicine
JF - Wilderness and Environmental Medicine
Y1 - 2005///
VL - 16
IS - 4
SP - 185
EP - 191
CY - Colorado Springs; USA
PB - Wilderness Medical Society
SN - 1080-6032
AD - Mode, N. A.: Alaska Field Station, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4230 University Dr, Suite 310, Anchorage, AK 99508, USA.
N1 - Accession Number: 20063004547. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Objective. - During 1992-2000, an average of 40 fatal occupational injuries and 12 400 nonfatal occupational injuries and illnesses related to animals were recorded each year in the United States, most involving domestic farm animals. Although Alaska has a relatively small farming industry, it supports several industries that require workers to regularly be in contact with animals. This study examines the pattern and characteristics of animal-related occupational injuries in Alaska. Methods. - Two data sources were accessed: the Alaska Trauma Registry for nonfatal injuries requiring hospitalization and the Alaska Occupational Injury Surveillance System for fatal injuries. The case definition included events in which the source of the injury was an animal or animal product (Occupational Injury and Illness Classification Manual source code 51). Results. - In Alaska during 1991-2000, there were 43 animal-related occupational injuries requiring hospitalization and 25 animal-related fatalities. There were only 2 fatal events: 1 bird-strike aircraft accident killing 24 military personnel and 1 bear attack. The majority of the nonfatal injury events were related to marine wildlife (n=20), with the rest related to either domesticated (n=11) or nondomesticated (n=12) mammals. Of events reporting a hospital charge (23 of 43), the average cost was over $9700 per person. Conclusions. - The catastrophic aircraft crash increased bird-control efforts near airports around the state. The nonfatal animal-related injuries have received less notice, although they result in thousands of dollars in hospital costs and lost workdays. Fishing-industry workers in particular should be made aware of potential injuries and educated on how to treat them when away from definitive medical care.
KW - costs
KW - domestic animals
KW - occupational hazards
KW - occupational health
KW - trauma
KW - Alaska
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - traumas
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063004547&site=ehost-live&scope=site
UR - email: nmode@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Awareness of foodborne pathogens among US consumers.
AU - Lin, C. T. J.
AU - Jensen, K. L.
AU - Yen, S. T.
JO - Food Quality and Preference
JF - Food Quality and Preference
Y1 - 2005///
VL - 16
IS - 5
SP - 401
EP - 412
CY - Oxford; UK
PB - Elsevier
SN - 0950-3293
AD - Lin, C. T. J.: Division of Market Studies, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20053093572. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition; Public Health
N2 - Each year in the United States, microbial pathogens cause millions of cases of foodborne disease and result in many hospitalizations and deaths. Effective consumer education programs to promote safer food handling practices and other averting behaviors may benefit from consumer awareness of microbial pathogens. This paper investigates US consumers' awareness of four major microbial pathogens (Salmonella, Campylobacter, Listeria and Escherichia coli) as food safety problems, using a multivariate probit model. The awareness varies among pathogens and the variations appear to be related to differences in the number and severity of illnesses associated with these pathogens. Our findings suggest that awareness of microbial pathogens is associated with food safety perceptions, awareness of potentially risky foods and substances associated with potential food safety hazards, food safety related behaviors, and demographics. There are differentiated effects of variables on awareness of the four pathogens.
KW - consumers
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - USA
KW - Campylobacter
KW - Escherichia coli
KW - Listeria
KW - man
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - food contaminants
KW - United States of America
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053093572&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09503293
UR - email: chung-tung.lin@cfsan.fda.gov\kjensen@utk.edu\syen@utk.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Platelet aggregation in whole blood is a paradoxical predictor of ischaemic stroke: Caerphilly Prospective Study revisited.
AU - Sharp, D. S.
AU - Ben-Shlomo, Y.
AU - Beswick, A. D.
AU - Andrew, M. E.
AU - Elwood, P. C.
JO - Platelets
JF - Platelets
Y1 - 2005///
VL - 16
IS - 6
SP - 320
EP - 328
CY - Basingstoke; UK
PB - Taylor & Francis
SN - 0953-7104
AD - Sharp, D. S.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road MS-4020, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053186505. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - The Caerphilly Prospective Study demonstrates a paradoxical association of increased ischaemic stroke risk with decreased whole blood adenosine diphosphate (ADP) induced platelet sensitivity. A reanalysis of this association examines whether other haematological indices and prevalent disease at baseline may explain this finding. There were 1506 men free of clinical cardiovascular disease at baseline, with 85 men manifesting a first ischaemic stroke event over 8.3 years of follow-up in this population-based prospective cohort study. Using two different approaches, the paradoxical findings are confirmed and associations are slightly stronger after accounting for red cell, platelet, and white cell indices. A U-shaped relation of stroke with platelet count is noted. These findings are consistent with the existence of sub-clinical endothelial disease and compensatory mechanisms down-regulating ADP-induced aggregation sensitivity. They support an allostasis model of causality for understanding the paradox. A public health approach to prevention could have measurable impact if intervention strategies can be developed to alter early stages of disease appropriate to such mechanisms of causation.
KW - aetiology
KW - cardiovascular diseases
KW - clotting
KW - human diseases
KW - ischaemia
KW - platelets
KW - stroke
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood platelets
KW - causal agents
KW - etiology
KW - ischemia
KW - thrombocytes
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053186505&site=ehost-live&scope=site
UR - http://journalsonline.tandf.co.uk/link.asp?id=100629
UR - email: dsharp@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quality-based payment: six case examples.
AU - McNamara, P.
JO - International Journal for Quality in Health Care
JF - International Journal for Quality in Health Care
Y1 - 2005///
VL - 17
IS - 4
SP - 357
EP - 362
CY - Oxford; UK
PB - Oxford University Press
SN - 1353-4505
AD - McNamara, P.: Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20053139705. Publication Type: Journal Article. Language: English. Language of Summary: Spanish. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Introduction. The logic of paying more for high-quality care and less for low-quality resonates. Increasingly health system leaders worldwide acknowledge that payment reforms are needed to do just that, prompted no doubt by the growing body of evidence indicating that quality is not what it should be. Purpose. This review was undertaken to explore contexts in which quality-based payment appears feasible. The ultimate intent is to provoke thoughtful debate about whether and how quality-based payment might fit within a particular developing country's framework of policies to ensure and promote quality of care. Methods. With guidance from key informants with first-hand knowledge of international quality-based payment schemes, a purposive sample of six quality-based payment schemes was assembled. Schemes were examined to identify environmental contexts and design features. Results. Examples illustrate a variety of approaches and a breadth of contexts in which quality-based payment has been implemented. Contrary to what might be expected, implementation does not appear to be constrained to private-sector purchasers, private-sector providers, hospital settings, nor to any particular type of underlying payment system. Further, quality-based payment pioneers are using a variety of incentive structures, and are tapping a rich mix of structural, process, and outcome standards to benchmark quality. Conclusion. Despite significant operational challenges, quality-based payment has been implemented in developing as well as developed countries, albeit not frequently in either instance. What we do not know - what the literature is nearly silent on - relates to the sustainability and ultimate impact of alternative incentive schemes.
KW - health care
KW - payment basis
KW - quality
KW - quality of care
KW - reviews
KW - quality-based payment
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053139705&site=ehost-live&scope=site
UR - http://intqhc.oxfordjournals.org/
UR - email: pmcnamar@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using data to make decisions: planning HIV/AIDS care under the Ryan White CARE Act.
AU - Hayes, C.
AU - Gambrell, A.
AU - Young, S.
AU - Conviser, R.
T3 - Special Issue: Use of HIV and other public health data for HIV prevention and care planning.
JO - AIDS Education and Prevention
JF - AIDS Education and Prevention
Y1 - 2005///
VL - 17
SP - 17
EP - 25
CY - New York; USA
PB - Guilford Publications
SN - 0899-9546
AD - Hayes, C.: Health Resources and Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Room 7-29, Rockville, MD 20857, USA.
N1 - Accession Number: 20063031595. Publication Type: Journal Article. Note: Special Issue: Use of HIV and other public health data for HIV prevention and care planning. Language: English. Number of References: 19 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - This article describes the challenges of using data to plan and fund HIV/AIDS care services for underserved populations under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act. It also outlines methods that have been developed by the Health Resources and Services Administration of the U.S. Department of Health and Human Services to assist community planning groups in using data to decide how to target limited federal resources under the CARE Act. Use of CARE Act dollars is guided largely by an array of legislatively identified priority areas, such as targeting of low income HIV-infected individuals who are not in care for their HIV disease. CARE Act program guidance covers the use of epidemiologic HIV and AIDS case data, quantification of unmet need for HIV care, guidance on making objective decisions on priorities for funding within a community planning process, and other instructions on the use of data in making decisions.
KW - acquired immune deficiency syndrome
KW - health policy
KW - health programs
KW - health services
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - human immunodeficiency virus infections
KW - United States of America
KW - Policy and Planning (EE120)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063031595&site=ehost-live&scope=site
UR - email: chayes@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians.
AU - Holland, R. D.
AU - Gehring, T.
AU - Taylor, J.
AU - Lake, B. G.
AU - Gooderham, N. J.
AU - Turesky, R. J.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2005///
VL - 18
IS - 3
SP - 579
EP - 590
CY - Washington; USA
PB - American Chemical Society
SN - 0893-228X
AD - Holland, R. D.: Division of Chemistry, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053072639. Publication Type: Journal Article. Language: English. Registry Number: 60-72-5. Subject Subsets: Human Nutrition
N2 - Liquid chromatography electrospray ionization mass spectrometry (MS) with a triple quadrupole MS was used to identify known and novel heterocyclic aromatic amines (HAAs) in human urine. The identities of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were confirmed by their product ion spectra. The constant neutral loss scan mode was employed to probe for other analytes in urine that display the transition [M+H]+->[M+H-CH3.]+., which is common to HAAs containing an N-methylimidazo moiety, and led to the detection of a previously unreported isomer of 8-MeIQx [Holland, R., et al. (2004) Chem. Res. Toxicol. 17, 1121-1136]. We now report the identification of another novel HAA, 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]), an isomer of the powerful animal carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). The amounts of IQ[4,5-b] measured in the urine of human volunteers who consumed grilled beef ranged from 15 to 135% of the ingested dose, while the amounts of 8-MeIQx and PhIP excreted in urine were on average <2% of the ingested dose. Base treatment of urine at 70°C increased the concentrations of 8-MeIQx and PhIP by as much as 6-fold, indicating the presence of phase II conjugates; however, the amount of IQ[4,5-b] increased by more than 100-fold. IQ[4,5-b] was also detected in the urine of vegetarians following base hydrolysis. The formation of IQ[4,5-b], but not IQ, 8-MeIQx, or PhIP, also occurred in urine incubated at 37°C. Creatinine and 2-aminobenzaldehyde are likely precursors of IQ[4,5-b]. The detection of IQ[4,5-b] in the urine of both meat eaters and vegetarians suggests that this HAA may be present in nonmeat staples or that IQ[4,5-b] formation may occur endogenously within the urinary bladder or other biological fluids.
KW - creatinine
KW - diets
KW - mutagens
KW - urine
KW - vegetarian diets
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - heterocyclic aromatic amines
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053072639&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/crtoec/2005/18/i03/abs/tx049675w.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antiretroviral therapies for treatment-experienced patients: current status and research challenges.
AU - Struble, K.
AU - Murray, J.
AU - Cheng, B.
AU - Gegeny, T.
AU - Miller, V.
AU - Gulick, R.
JO - AIDS
JF - AIDS
Y1 - 2005///
VL - 19
IS - 8
SP - 747
EP - 756
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Struble, K.: Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053093773. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Public Health
KW - antiviral agents
KW - drug resistance
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - multiple drug therapy
KW - structured treatment interruption
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - combination drug therapy
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053093773&site=ehost-live&scope=site
UR - email: vmiller@gwu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries.
AU - McDougal, J. S.
AU - Pilcher, C. D.
AU - Parekh, B. S.
AU - Gershy-Damet, G.
AU - Branson, B. M.
AU - Marsh, K.
AU - Wiktor, S. Z.
T3 - New strategies for HIV/AIDS surveillance in resource-constrained countries.
JO - AIDS
JF - AIDS
Y1 - 2005///
VL - 19
IS - Suppl.2
SP - s25
EP - s30
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - McDougal, J. S.: National Center for HIV/AIDS, STD, TB Prevention, Centers for Disease Control and Prevention, US Public Health Service, Mail stop A25, Atlanta, GA 30333, USA.
N1 - Accession Number: 20053139057. Publication Type: Journal Article. Note: New strategies for HIV/AIDS surveillance in resource-constrained countries. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - Over the past few years, several assays have been developed for the purpose of estimating HIV-1 incidence from cross-sectional population surveys. The tests detect features of the evolving virological or immunological response to HIV-1 infection that distinguish recent from established infection. Surveillance programmes that collect specimens from population surveys for HIV-1 prevalence can apply some of these tests to the same specimen sets to estimate incidence. We describe these tests and discuss the principle and strategy for implementation of a testing programme for recent infection in surveillance settings. Test-specific prerequisites, such as calibration, validation, and quality assurance, and other test-specific performance characteristics that may influence interpretation, epidemiological considerations that may guide application, and practical operational considerations for implementation in surveillance settings are considered. When properly and judiciously applied, the capacity to estimate incidence from existing programmes that conduct surveillance for prevalent HIV-1 infection will enhance the capacity for more precise and timely analysis of the dynamics of the epidemic and the effectiveness of public health interventions.
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - HIV-1 infections
KW - human diseases
KW - surveillance
KW - viral diseases
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus type 1
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053139057&site=ehost-live&scope=site
UR - email: jsm3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Injuries and illnesses treated at the World Trade Center, 14 September-20 November 2001.
AU - Perritt, K. R.
AU - Boal, W. L.
JO - Prehospital and Disaster Medicine
JF - Prehospital and Disaster Medicine
Y1 - 2005///
VL - 20
IS - 3
SP - 177
EP - 183
CY - Madison; USA
PB - World Association for Disaster and Emergency Medicine
AD - Perritt, K. R.: Special Studies Team Surveillance and Field Investigations Branch, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 1808, Morgantown, WV 26505, USA.
N1 - Accession Number: 20053189464. Publication Type: Journal Article. Corporate Author: USA, The Helix Group Inc. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Introduction: In response to the 11 September 2001 terrorist attacks on the World Trade Center (WTC), the United States Public Health Service (USPHS) deployed Disaster Medical Assistance Teams (DMATs) and the Commissioned Corps to provide on-site, primary medical care to anyone who presented. Patients included rescue and recovery workers, other responders, and some members of the general public. Objective: A descriptive analysis of WTC-USPHS patient records was conducted in order to better understand the short-term impact of the WTC site on the safety and health of individuals who were at or near the site from 14 September-20 November 2001. Methods: The Patient Treatment Record forms that were completed for each patient visit to these USPHS stations over the 10-week deployment period were reviewed. Results: Patient visits numbered 9349, with visits peaking during Week 2 (21-27 September). More than one-quarter of the visits were due to traumatic injuries not including eye injuries (n=2716; 29%). Respiratory problems comprised more than one-fifth of the complaints (n=2011; 22%). Eye problems were the third most frequent complaint (n=1120; 12%). With respect to the triage class, the majority of visits fell into the lowest category of severity (n=6237; 67%). Conclusion: USPHS visits probably were skewed to milder complaints when compared to analyses of employer medical department reports or hospital cases; however, given the close proximity of the USPHS stations to the damage, analysis of the USPHS forms provides a more complete picture of the safety and health impact on those who were at or near the WTC site.
KW - eye diseases
KW - human diseases
KW - respiratory diseases
KW - safety
KW - terrorism
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - traumas
KW - United States of America
KW - Conflict (UU495) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053189464&site=ehost-live&scope=site
UR - http://pdm.medicine.wisc.edu/20-3%20PDFs/Perritt.pdf
UR - email: kperritt@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breast pump adverse events: reports to the food and drug administration.
AU - Brown, S. L.
AU - Bright, R. A.
AU - Dwyer, D. E.
AU - Foxman, B.
JO - Journal of Human Lactation
JF - Journal of Human Lactation
Y1 - 2005///
VL - 21
IS - 2
SP - 169
EP - 174
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 0890-3344
AD - Brown, S. L.: Division of Postmarket Surveillance, Epidemiology Branch, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, HFZ-541, Rockville, MD 20850, USA.
N1 - Accession Number: 20053117844. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition; Dairy Science; Public Health
N2 - Breast pumps are medical devices used to express milk and maintain the milk supply. The purpose of this study was to characterize adverse events reported to the United States Food and Drug Administration (FDA) on breast pumps. Thirty-seven adverse event reports on breast pumps were identified from the Manufacturer and User Facility Device Experience database between 1992 and 2003. Four additional reports were found in the Device Experience Network database from 1992 to 1996. The most commonly reported adverse events for electric breast pumps were pain, soreness, or discomfort; the need for medical intervention; and breast tissue damage. Most frequently reported problems for manual breast pumps were breast tissue damage and infection. Contamination of breast milk during pumping was also reported. Breast pump adverse events are likely underreported to the FDA. Reporting adverse events is important for improving the design and manufacture of breast pumps and subsequently decreasing adverse events.
KW - breast
KW - breast feeding
KW - breast pumps
KW - epidemiology
KW - equipment
KW - human diseases
KW - infant feeding
KW - infants
KW - mammary glands
KW - pain
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - breasts
KW - United States of America
KW - Physiology of Human Nutrition (VV120)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053117844&site=ehost-live&scope=site
UR - http://jhl.sagepub.com/
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High-methoxyl pectin has greater enhancing effect on glucose uptake in intestinal perfused rats.
AU - Kim MeeHye
JO - Nutrition
JF - Nutrition
Y1 - 2005///
VL - 21
IS - 3
SP - 372
EP - 377
CY - New York; USA
PB - Elsevier
SN - 0899-9007
AD - Kim MeeHye: Department of Risk Analysis, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20053071335. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 50-99-7. Subject Subsets: Human Nutrition
N2 - Objective: Pectins have been known to decrease blood glucose levels. However, the mechanism of this effect is unclear. The direct action of various pectins (high- or low-methoxyl pectins) on the intestinal absorption of glucose was investigated in gut-perfused rats. Methods: After equilibrium, jejunal and ileal segments were simultaneously perfused with an isotonic electrolyte solution (pH 7.4) containing glucose (10 mM/L) and high- or low-methoxyl pectins (10 g/L). Each test or control solution was perfused in a random sequence, with perfusion times of 30 min. Changes in glucose concentration of perfusate solution reservoir were determined over the experimental period. Results: High- and low-methoxyl pectins in the perfusate significantly inhibited jejunal uptake of glucose compared with the control (P<0.05). High-methoxyl pectins had greater inhibitive effect on intestinal absorption of glucose than low-methoxyl pectins. The observed changes in glucose and water absorptions caused by high- or low-methoxyl pectins were reversible by switching to a pectin-free perfusate. In addition, net water absorption changed to secretion after addition of high- or low-methoxyl pectins. Conclusions: These results suggest that the decrease in intestinal absorption of glucose observed after perfusion of high- or low-methoxyl pectins may be caused by viscosity-related increases in mucosal unstirred layer thickness.
KW - animal models
KW - blood sugar
KW - glucose
KW - ileum
KW - intestinal absorption
KW - intestines
KW - jejunum
KW - laboratory animals
KW - pectins
KW - perfusion
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood glucose
KW - dextrose
KW - glucose in blood
KW - methoxyl pectin
KW - water absorption
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053071335&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08999007
UR - email: meehkim@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modulation of immune responses during HIV-malaria co-infection in pregnancy.
AU - Ned, R. M.
AU - Moore, J. M.
AU - Chaisavaneeyakorn, S.
AU - Udhayakumar, V.
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2005///
VL - 21
IS - 6
SP - 284
EP - 291
CY - Oxford; UK
PB - Elsevier
SN - 1471-4922
AD - Ned, R. M.: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Chamblee, GA 30341, USA.
N1 - Accession Number: 20053104646. Publication Type: Journal Article. Language: English. Number of References: 77 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology; Protozoology; Tropical Diseases
N2 - Infection with either HIV or malaria during pregnancy often results in adverse outcomes for mother and child. Co-infection further increases the risks of these events, which include maternal anemia and babies with low birth weight. The immunological bases for the increased susceptibility of HIV-1-infected mothers to Plasmodium falciparum malaria and for the effect of co-infection on mother-to-child transmission of HIV-1 are areas of major importance in public health. In this article, we review current data about humoral and cellular responses to HIV-placental-malaria co-infection, and present an immunological hypothesis to explain the epidemiological findings.
KW - antibodies
KW - cell mediated immunity
KW - concurrent infections
KW - fetus
KW - HIV-1 infections
KW - human diseases
KW - humoral immunity
KW - immune response
KW - immunocompromised hosts
KW - immunopathology
KW - malaria
KW - maternal transmission
KW - opportunistic infections
KW - placenta
KW - pregnancy
KW - pregnancy complications
KW - reviews
KW - risk factors
KW - T lymphocytes
KW - transplacental transmission
KW - women
KW - Human immunodeficiency virus 1
KW - man
KW - Plasmodium falciparum
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - cellular immunity
KW - foetus
KW - gestation
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - mother to child transmission
KW - T cells
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053104646&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/14714922
UR - email: vxu0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacterial identification by near-infrared chemical imaging of food-specific cards.
AU - Dubois, J.
AU - Lewis, E. N.
AU - Fry, F. S., Jr.
AU - Calvey, E. M.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2005///
VL - 22
IS - 6
SP - 577
EP - 583
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Dubois, J.: Joint Institute for Food Safety and Applied Nutrition (JIFSAN), Food and Drug Administration, University of Maryland College Park, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053107662. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition
N2 - Near-infrared chemical imaging (NIR-CI) is investigated as a tool for the high-throughput analysis of self-contained microbial identification test cards for micro-organisms of concern in food. In this initial work, a NIR-CI system operating in the spectral range 1000-2350 nm was used to acquire NIR chemical images of bacterial cells deposited on a 'card', containing both the calibration and test samples. Results show that some bacteria can be identified from differences observed at unique wavelengths, and that a standard operating procedure can be developed for a particular 'card' to differentiate and hence identify the various organisms it contains using discrete wavelengths. For situations where a particular organism of concern is sought, a PLS chemometric model may offer better performance by accounting for variables that can be incorporated in the calibration without the need to know the taxonomic identity of the complete complement of bacteria present on the 'card'. Overall, the NIR-CI results obtained in this investigation show that this high throughput technique possesses the specificity required to differentiate bacteria on the basis of their NIR spectra.
KW - foods
KW - infrared radiation
KW - microorganisms
KW - bacteria
KW - prokaryotes
KW - bacterium
KW - micro-organisms
KW - near infrared chemical imaging
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053107662&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: frederick.fry@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Socio-economic inequalities in the prevalence of Type 2 diabetes, cardiovascular risk factors and chronic diabetic complications in the Basque Country, Spain.
AU - Larrañaga, I.
AU - Arteagoitia, J. M.
AU - Rodriguez, J. L.
AU - Gonzalez, F.
AU - Esnaola, S.
AU - Piniés, J. A.
JO - Diabetic Medicine
JF - Diabetic Medicine
Y1 - 2005///
VL - 22
IS - 8
SP - 1047
EP - 1053
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0742-3071
AD - Larrañaga, I.: Epidemiology Unit, Public Health Service, Basque Government, Vitoria-Gasteiz, Spain.
N1 - Accession Number: 20053128881. Publication Type: Journal Article. Corporate Author: Spain, Sentinel Practice Network of the Basque Country Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Aims: To establish the relationship between socio-economic status and the prevalence of known Type 2 diabetes, cardiovascular risk factors and chronic diabetic complications. Methods: In 2000, a cross-sectional survey was conducted among 61 general practitioners (GPs) who studied 65 651 people older than 24 years. Of those, 2985 known Type 2 diabetic patients were registered. The main outcome measures were: diabetes prevalence, major cardiovascular risk factors, chronic diabetic complications and primary care services utilization in Type 2 diabetic patients. Socio-economic status was based on area-based socio-economic measures. Results: The prevalence of known Type 2 diabetes was higher in patients of lower socio-economic status (OR: 2.17, 95% CI: 1.77-2.28), especially among women (OR: 2.28, 95% CI: 1.91-2.73). In Type 2 diabetes patients, obesity, sedentary lifestyle, and abnormal levels of low-density lipoprotein (LDL) cholesterol and HbA1c were more prevalent among those from lower socio-economic status. Macroangiopathy was inversely associated with socio-economic status after adjustment for clinical and demographic variables. Patients of lower socio-economic status more frequently visited primary care services than those of higher status. Conclusions: This study shows an association between deprivation and Type 2 diabetes prevalence, cardiovascular risk factors and chronic diabetic complications in Type 2 diabetes patients. Despite a greater use of health services by less wealthy patients, they showed worse glycaemic control and more chronic complications. Besides clinical variables, socio-economic status and environmental information need to be considered in the assessment of risk profile of diabetic patients by health professionals and by health service planners.
KW - blood sugar
KW - cardiovascular diseases
KW - chronic course
KW - complications
KW - deprivation
KW - diabetes mellitus
KW - disease prevalence
KW - epidemiology
KW - health care
KW - health services
KW - human diseases
KW - lifestyle
KW - low density lipoprotein
KW - men
KW - obesity
KW - risk factors
KW - sex differences
KW - socioeconomic status
KW - women
KW - Spain
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - blood glucose
KW - fatness
KW - glucose in blood
KW - low density lipoprotein cholesterol
KW - type 2 diabetes mellitus
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053128881&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=dme
UR - email: ilarranaga@ej-gv.es
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thresholds as a unifying theme in regulatory toxicology.
AU - Cheeseman, M. A.
A2 - Gilbert, J.
A2 - Theobald, A.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2005///
VL - 22
IS - 10
SP - 900
EP - 906
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Cheeseman, M. A.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063009304. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 13 ref. Subject Subsets: Agricultural Engineering; Human Nutrition; Public Health
N2 - The scientific basis for the US Food and Drug Administration (FDA) threshold of regulation is discussed in relation to its toxicological testing recommendations for food contact substances and the existing methods it employs for exposure estimation. A case is made that the FDA's threshold of regulation is a natural extension of its toxicity testing regime. The genetic toxicity tests recommended in the exposure-based toxicological testing framework for food contact substances are examined regarding their ability to predict positively carcinogens of varying potency. In addition, the computational toxicology program MULTICASE v. 3.1 is also examined for its ability to predict positively carcinogens of varying potency. It is concluded that MULTICASE can provide equivalent results to genetic toxicity tests at the lowest dietary concentrations.
KW - carcinogens
KW - computer techniques
KW - food contamination
KW - food safety
KW - methodology
KW - toxic substances
KW - toxicity
KW - toxicology
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - computer applications
KW - food contaminants
KW - methods
KW - poisons
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063009304&site=ehost-live&scope=site
UR - email: Mitchell.Cheeseman@FDA.Gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perfluorochemicals: potential sources of and migration from food packaging.
AU - Begley, T. H.
AU - White, K.
AU - Honigfort, P.
AU - Twaroski, M. L.
AU - Neches, R.
AU - Walker, R. A.
A2 - Gilbert, J.
A2 - Theobald, A.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2005///
VL - 22
IS - 10
SP - 1023
EP - 1031
CY - London; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Begley, T. H.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20063009299. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 23 ref. Subject Subsets: Agricultural Engineering; Human Nutrition
N2 - Perfluorochemicals are widely used in the manufacturing and processing of a vast array of consumer goods, including electrical wiring, clothing, household and automotive products. Furthermore, relatively small quantities of perfluorochemicals are also used in the manufacturing of food-contact substances that represent potential sources of oral exposure to these chemicals. The most recognizable products to consumers are the uses of perfluorochemicals in non-stick coatings (polytetrafluoroethylene (PTFE)) for cookware and also their use in paper coatings for oil and moisture resistance. Recent epidemiology studies have demonstrated the presence of two particular perfluorochemicals, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in human serum at very low part per billion levels. These perfluorochemicals are biopersistent and are the subject of numerous studies investigating the many possible sources of human exposure. Among the various uses of these two chemicals, PFOS is a residual impurity in some paper coatings used for food contact and PFOA is a processing aid in the manufacture of PTFE used for many purposes including non-stick cookware. Little information is available on the types of perfluorochemicals that have the potential to migrate from perfluoro coatings into food. One obstacle to studying migration is the difficulty in measuring perfluorochemicals by routine conventional analytical techniques such as GC/MS or LC-UV. Many perfluorochemicals used in food-contact substances are not detectable by these conventional methods. As liquid chromatography-mass spectrometry (LC/MS) develops into a routine analytical technique, potential migrants from perfluoro coatings can be more easily characterized. In this paper, data will be presented on the types of perfluoro chemicals that are used in food packaging and cookware. Additionally, research will be presented on the migration or potential for migration of these chemicals into foods or food simulating liquids. Results from migration tests show mg kg-1 amounts of perfluoro paper additives/coatings transfer to food oil. Analysis of PTFE cookware shows residual amounts of PFOA in the low µg kg-1 range. PFOA is present in microwave popcorn bag paper at amounts as high as 300 µg kg-1.
KW - food contamination
KW - food safety
KW - packaging materials
KW - toxic substances
KW - food contaminants
KW - perfluorochemicals
KW - perfluorooctane sulfonate
KW - perfluorooctanoic acid
KW - poisons
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063009299&site=ehost-live&scope=site
UR - email: tbegley@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stability, dose uniformity, and palatability of three counterterrorism drugs - human subject and electronic tongue studies.
AU - Sadrieh, N.
AU - Brower, J.
AU - Yu, L.
AU - Doub, W.
AU - Straughn, A.
AU - Machado, S.
AU - Pelsor, F.
AU - Saint Martin, E.
AU - Moore, T.
AU - Reepmeyer, J.
AU - Toler, D.
AU - Nguyenpho, A.
AU - Roberts, R.
AU - Schuirmann, D. J.
AU - Nasr, M.
AU - Buhse, L.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2005///
VL - 22
IS - 10
SP - 1747
EP - 1756
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0724-8741
AD - Sadrieh, N.: Food and Drug Administration, 5515 Security Lane, Rockville, MD 20852, USA.
N1 - Accession Number: 20053205560. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 85721-33-1, 24390-14-5, 10592-13-9, 564-25-0, 7681-11-0. Subject Subsets: Public Health
N2 - Purpose. These studies evaluated the ability of common household food and drink products to mask the bitter taste of three selected anti-terrorism drugs. Methods. Three anti-terrorism drugs (doxycycline, ciprofloxacin hydrochloride, and potassium iodide) were mixed with a variety of common household food and drinks, and healthy adult volunteers evaluated the resulting taste and aftertaste. In parallel, the ASTREE Electronic Tongue was used to evaluate taste combinations. Stability of the mixtures over time was monitored, as was the dosage uniformity across preparations. Results. Foods and drinks were identified that satisfactorily masked the bitter flavor of each drug. Dose uniformity and stability were also acceptable over the range studied, although some combinations were significantly less stable than others. The electronic tongue was able to differentiate between tastes, but ranked masking agents in a different order than human volunteers. Conclusions. Doxycycline, potassium iodide, and ciprofloxacin, which are stockpiled in solid tablet form, can conveniently be prepared into more palatable formulations, using common household foods and drinks. The electronic tongue can be used to perform an initial screening for palatability.
KW - chemistry
KW - ciprofloxacin
KW - dosage
KW - doxycycline
KW - drug delivery systems
KW - drug formulations
KW - drug therapy
KW - palatability
KW - potassium iodide
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - administration routes
KW - chemotherapy
KW - United States of America
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053205560&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=105282
UR - email: doubw@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Programming of CTL with heat-killed Brucella abortus and antigen allows soluble antigen alone to generate effective secondary CTL.
AU - Inoue, S.
AU - Golding, B.
AU - Scott, D.
JO - Vaccine
JF - Vaccine
Y1 - 2005///
VL - 23
IS - 14
SP - 1730
EP - 1738
CY - Oxford; UK
PB - Elsevier
SN - 0264-410X
AD - Inoue, S.: Center for Biologics Evaluation and Research, Division of Hematology, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053076011. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9008-11-1. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Optimal generation of cytotoxic T cell (CTL) responses continues to be a challenge in the production of vaccines against pathogens such as HIV-1, in part because it is difficult to introduce soluble protein antigens (Ag) into the MHC class I pathway. Using heat-killed Brucella abortus (HKBA) as an adjuvant and ovalbumin (ova) protein as an Ag, we demonstrated that a high dose of Ag was required for systemic and effective CTL. In an adoptive transfer model, primary and secondary ova-specific OT-1 CD8 cell expansion by HKBA plus high dose of ova were partially CD4 T cell-dependent. Interestingly, primary stimulation with HKBA plus ova allowed effective secondary stimulation with ova alone that was equivalent to HKBA plus ova in terms of IFN-γ production from Ag-specific CD8 cells. Thus a combination of adequate Ag dose, and selection of appropriate adjuvants can meet the threshold not only for primary effective CTL responses to soluble protein Ags but for secondary CTL responses following stimulation with protein Ag alone.
KW - antigens
KW - cytotoxic T lymphocytes
KW - HIV-1 infections
KW - human diseases
KW - immune response
KW - interferon
KW - vaccine development
KW - vaccines
KW - viral diseases
KW - Brucella abortus
KW - Human immunodeficiency virus 1
KW - man
KW - Brucella
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenicity
KW - bacterium
KW - human immunodeficiency virus type 1
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053076011&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: inoue@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants.
AU - Berthold, I.
AU - Pombo, M. L.
AU - Wagner, L.
AU - Arciniega, J. L.
JO - Vaccine
JF - Vaccine
Y1 - 2005///
VL - 23
IS - 16
SP - 1993
EP - 1999
CY - Oxford; UK
PB - Elsevier
SN - 0264-410X
AD - Berthold, I.: Center for Biologics Evaluation and Research, US FDA, CBER/DBPAP [HFM-443], 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20053075845. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 21645-51-2, 7784-30-7. Subject Subsets: Public Health
N2 - The only US-licensed anthrax vaccine for human use, as well as several experimental vaccines containing solely purified recombinant protective antigen (rPA), are formulated using aluminum hydroxide (Al(OH)3) as an adjuvant. It has been suggested that effective adjuvanticity of aluminum salts for protein antigens depends, at least partially, on the degree of adsorption of the antigen to the adjuvant. On the other hand, the ease of antigen desorption from the adjuvant in a quantitative fashion may facilitate the assessment of vaccine characteristics in the laboratory. In this regard, aluminum phosphate (AlPO4), although deemed a "weaker" adjuvant than Al(OH)3, appears superior to the latter. To investigate the possibility of formulating rPA vaccines with AlPO4, as well as the significance of the adsorption of this antigen to the aluminum salt for adjuvanticity, we studied the effect of AlPO4 and Al(OH)3 on the induction of anti-rPA antibodies in mice. In a first immunization experiment the adjuvanticity of AlPO4 combined with rPA was examined. Antibodies against rPA were measured using an ELISA. Results indicated that AlPO4 is able to significantly increase the antibody response to rPA, irrespective of its degree of adsorption to the adjuvant. Based on these results, in a second experiment mice were immunized twice, with different formulations of rPA containing either AlPO4 or Al(OH)3, and rPA-antibodies were measured using ELISA and an in vitro toxin neutralization assay. Comparable immune responses to rPA were obtained with both aluminum salts. Additionally, results with AlPO4 as adjuvant confirmed that, in this mouse model, binding of the protein to the adjuvant is not essential for adjuvanticity, whereas the amount of adjuvant has an influence on the antibody response induced.
KW - adjuvants
KW - aluminium hydroxide
KW - aluminium phosphate
KW - animal models
KW - anthrax
KW - bacterial diseases
KW - human diseases
KW - immune response
KW - recombinant vaccines
KW - Bacillus anthracis
KW - man
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - aluminum hydroxide
KW - aluminum phosphate
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053075845&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: ingeberthold@web.de\inge.berthold@bavarian-nordic.com\mariluzpombo@telcel.net.ve\Arciniega@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries.
AU - Walker, R. I.
JO - Vaccine
JF - Vaccine
Y1 - 2005///
VL - 23
IS - 26
SP - 3369
EP - 3385
CY - Oxford; UK
PB - Elsevier
SN - 0264-410X
AD - Walker, R. I.: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA.
N1 - Accession Number: 20053093882. Publication Type: Journal Article. Language: English. Number of References: 182 ref. Subject Subsets: Tropical Diseases
N2 - Enteric pathogens constitute a major paediatric threat in the developing world through their impact on morbidity and mortality, physical and cognitive development and cause and effect relationship with malnutrition. Although many bacterial pathogens can cause diarrheal diseases, a group of less than 10 including Shigella spp., enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae, and possibly, Campylobacter jejuni account for a significant percentage of these diseases in developing countries. Rotavirus is also a major cause of diarrheal diseases. Vaccines against these agents offer a potentially effective control measure against these diseases, but safe, practical, and effective vaccines for many of these agents have yet to be realized. Many vaccine development approaches are under investigation, but the one that is currently most advanced and that has been most widely applied to enteric pathogens is the use of orally administered live or killed whole pathogen preparations. If inactivated, these vaccines will probably be administered as multiple doses with approximately 1010 to 1011 total particles per dose, but they are relatively safe for oral administration. Further, they may not require a buffer for delivery and can be stored in liquid formulations. Fewer doses may be required for some live attenuated pathogen vaccines, but a buffer will most likely be required for oral delivery and the product must be stored in a dried formulation. Also, safety becomes more of a concern with live pathogens depending on the degree of attenuation, host immunocompetence, and the total number and kinds of attenuated pathogens which may be present in a combined agent vaccine. Both live and killed whole pathogen vaccines can be immunogenic and have the possibility to serve as vectors for other antigens. Although many organisms and serotypes are clinically important, by exploiting antigenic cross reactivity and using some pathogen components as vectors for cloned antigens of other pathogens, it could be possible to induce immunity against major enteric pathogens/serotypes with <10 whole pathogen components in a multi-agent vaccine. Safe and effective mucosal adjuvants may in the future be useful in whole pathogen vaccines, but they do not seem to be essential for immunization. Further, dietary supplements such as zinc, mixed routes of delivery and new regimens are under study which may in the future enhance further the effectiveness of the whole pathogen vaccines which now seem realizable in the near term. For this to happen, however, a coordinated and committed effort is necessary now to address the immunologic, regulatory, manufacturing, testing and implementation issues which will be involved in the realization of this important product to benefit children's health worldwide.
KW - adjuvants
KW - children
KW - diarrhoea
KW - disease control
KW - efficacy
KW - human diseases
KW - immune response
KW - immunity
KW - immunization
KW - inactivated vaccines
KW - live vaccines
KW - malnutrition
KW - reviews
KW - vaccine development
KW - vaccines
KW - whole cell vaccines
KW - Developing Countries
KW - Campylobacter jejuni
KW - Escherichia coli
KW - man
KW - Rotavirus
KW - Shigella
KW - Vibrio cholerae
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - countries
KW - attenuated vaccines
KW - bacterial vaccines
KW - bacterins
KW - bacterium
KW - diarrhea
KW - E. coli
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - killed vaccines
KW - scouring
KW - Third World
KW - Underdeveloped Countries
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053093882&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: walkerri@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measuring the health consequences of alcohol consumption: current needs and methodological challenges.
AU - Bloss, G.
JO - Digestive Diseases
JF - Digestive Diseases
Y1 - 2005///
VL - 23
IS - 3/4
SP - 162
EP - 169
CY - Basel; Switzerland
PB - S Karger AG
SN - 0257-2753
AD - Bloss, G.: National Institute on Alcohol Abuse and Alcoholism, Division of Epidemiology and Prevention Research, National Institutes of Health, US Department of Health and Human Services, 5635 Fishers Lane, Room 2075, Bethesda, MD 20892-9304, USA.
N1 - Accession Number: 20063046223. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background/Aims: Extensive research has shown that alcohol consumption leads to poor health and premature death through its causal or contributing roles in numerous chronic health conditions and acute health outcomes, including various cancers, liver disease and injuries. Paradoxically, advances in understanding of the causal associations between alcohol consumption and various conditions have complicated our ability to discern trends in the health consequences of alcohol consumption over time. Methods: Four distinct needs for information on the role of alcohol in causing adverse health outcomes were identified. Estimates of alcohol-attributable mortality from 2 studies in the USA were compared and differences were identified. Results: Differences in the conditions included and alcohol-attributable fractions employed accounted for large differences in the estimated alcohol-attributable mortality for several health outcomes. Conclusion: Despite the broad consensus on many health consequences of alcohol consumption, further research is needed to clarify the conditions that are caused by alcohol consumption, magnitudes of causal relationships, and effects of different patterns of consumption and individual characteristics. Comparisons over time are needed to identify areas where improvements in public health may be occurring or are most needed, to support evaluation of specific interventions, and to encourage the public awareness of alcohol problems that is necessary to change attitudes and behaviours involving alcohol consumption.
KW - alcohol intake
KW - alcoholic beverages
KW - alcoholism
KW - health
KW - human diseases
KW - mortality
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - death rate
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063046223&site=ehost-live&scope=site
UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ProduktNr=224231&Ausgabe=231563&ArtikelNr=90162
UR - email: gbloss@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enteric vaccines for pediatric use: workshop summary.
AU - Walker, R. I.
AU - Verg, L. L. van de
AU - Hall, R. H.
AU - Schmitt, C. K.
AU - Woo, K.
AU - Hale, V.
JO - Vaccine
JF - Vaccine
Y1 - 2005///
VL - 23
IS - 46/47
SP - 5432
EP - 5439
CY - Oxford; UK
PB - Elsevier
SN - 0264-410X
AD - Walker, R. I.: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA.
N1 - Accession Number: 20053215551. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases; Public Health
N2 - Diarrheal diseases remain a major cause of death in children under 5 in less developed countries (LDCs). Vaccine development and implementation offers the best near-term approach to alleviating this problem. For this reason, a workshop to examine the possibilities for making enteric vaccines available to meet the specific needs of children in LDCs was convened in Virginia on April 24-26, 2004. Discussants considered research and development needs, regulatory and business issues, and previous experiences with enteric vaccine development and implementation. No insurmountable roadblocks to progress in this area were noted, and the possibility currently exists that properly supported efforts will enable the realization of enteric vaccines for pediatric use.
KW - adjuvants
KW - bacterial diseases
KW - campylobacteriosis
KW - children
KW - cholera
KW - diarrhoea
KW - human diseases
KW - immunization
KW - medical research
KW - regulations
KW - shigellosis
KW - typhoid
KW - vaccination
KW - vaccine development
KW - vaccines
KW - viral diseases
KW - Campylobacter jejuni
KW - Escherichia coli
KW - man
KW - Rotavirus
KW - Salmonella typhi
KW - Shigella
KW - Vibrio cholerae
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - diarrhea
KW - E. coli
KW - immune sensitization
KW - Less Developed Countries
KW - rules
KW - scouring
KW - viral infections
KW - Research (AA500)
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053215551&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: walkerri@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neonatal sepsis in Egypt associated with bacterial contamination of glucose-containing intravenous fluids.
AU - Moore, K. L.
AU - Kainer, M. A.
AU - Badrawi, N.
AU - Afifi, S.
AU - Wasfy, M.
AU - Bashir, M.
AU - Jarvis, W. R.
AU - Graham, T. W.
AU - El-Kholy, A.
AU - Gipson, R.
AU - Jernigan, D. B.
AU - Mahoney, F.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2005///
VL - 24
IS - 7
SP - 590
EP - 594
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Moore, K. L.: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20053153297. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 50-99-7. Subject Subsets: Tropical Diseases
N2 - Background: Rates of sepsis exceeding 50% in a neonatal intensive care unit (NICU) in Cairo, Egypt, were not controlled by routine antimicrobial therapy. We investigated these conditions in September 2001. Methods: Case series and retrospective cohort studies were conducted on 2 groups of NICU infants admitted to an academic medical centre between February 12 and July 31, 2001. Observation of clinical practices led us to culture in-use intravenous (i.v.) fluids and medications. We monitored rates of i.v. fluid contamination, clinical sepsis and mortality after interventions to establish new procedures for handling and disposal of i.v. fluids, infection control training and improved clinical laboratory capacity. Results: Among infants in the retrospective cohort group, 88 (77%) of 115 had clinical sepsis, and 59 (51%) died. In the case series group, we documented the time of initial positive blood culture; 21 (64%) of 33 were septic <24 hours after birth. Klebsiella pneumoniae accounted for 24 (73%) of 33 isolates; 14 (58%) of 24 were extended spectrum β-lactamase-producing and aminoglycoside-resistant. On admission, all neonates received glucose-containing i.v. fluids; i.v. bottles (500 mL) were divided among multiple infants. The i.v. fluids were prepared at the bedside; poor hand hygiene and poor adherence to aseptic techniques were observed. K. pneumoniae was isolated from 13 (65%) of 20 in-use glucose-containing i.v. fluids. Fluid contamination, sepsis and mortality rates declined significantly after intervention. Conclusion: Extrinsically contaminated i.v. fluids resulted in sepsis and deaths. Standard infection control precautions significantly improve mortality and sepsis rates and are prerequisites for safe NICU care.
KW - bacterial diseases
KW - contamination
KW - glucose
KW - human diseases
KW - infants
KW - intensive care units
KW - sepsis
KW - Egypt
KW - bacteria
KW - Klebsiella pneumoniae
KW - man
KW - prokaryotes
KW - Klebsiella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Mediterranean Region
KW - Middle East
KW - North Africa
KW - Africa
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - dextrose
KW - Misr
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053153297&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An age-adjusted bootstrap-based Poly-k test.
AU - Moon, H. J.
AU - Ahn, H. S.
AU - Kodell, R. L.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 2005///
VL - 24
IS - 8
SP - 1233
EP - 1244
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0277-6715
AD - Moon, H. J.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053061916. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - The assumption of an asymptotic normal distribution of some test statistics may be invalid in certain dose-response trend tests. For instance, the survival-adjusted Cochran-Armitage test, known as the Poly-k test, is asymptotically standard normal under the null hypothesis. However, the asymptotic normality is not valid if there is a deviation from the tumour onset distribution that is assumed in this test or if the competing risks survival rates differ across groups. We develop an age-adjusted bootstrap-based method to assess the significance of assumed asymptotic normal tests for animal carcinogenicity data. The proposed method differs from conventional bootstrap methods in the aspect of preserving the mortality rate in each dose group under the null hypothesis of equal tumour incidence rates among the groups. We investigate an empirical distribution of the Poly-3 (P3) trend test statistic using the proposed age-adjusted bootstrap-based method and compare it with the P3 test statistic referenced to the assumed standard normal distribution. A simulation study is conducted to evaluate the robustness of these tests to various Weibull-family tumour onset distributions. The proposed method is applied to National Toxicology Program data sets to evaluate a dose-related trend of a test substance on the incidence of neoplasms.
KW - age
KW - disease incidence
KW - epidemiology
KW - human diseases
KW - mortality
KW - neoplasms
KW - statistical analysis
KW - survival
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - death rate
KW - statistical methods
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053061916&site=ehost-live&scope=site
UR - email: hmoon@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A linear model for managing the risk of antimicrobial resistance originating in food animals.
AU - Bartholomew, M. J.
AU - Vose, D. J.
AU - Tollefson, L. R.
AU - Travis, C. C.
JO - Risk Analysis
JF - Risk Analysis
Y1 - 2005///
VL - 25
IS - 1
SP - 99
EP - 108
CY - Boston; USA
PB - Blackwell Publishing
SN - 0272-4332
AD - Bartholomew, M. J.: FDA Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20053056834. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Veterinary Science; Poultry; Public Health; Veterinary Science
N2 - A linear population risk model used by the U.S. Food and Drug Administration (FDA) Center for Veterinary Medicine (CVM) estimates the risk of human cases of campylobacteriosis caused by fluoroquinolone-resistant Campylobacter. Among the cases of campylobacteriosis attributed to domestically produced chicken, the fluoroquinolone resistance is assumed to result from the use of fluoroquinolones in poultry in the United States. Properties of the linear population risk model are contrasted with those of a farm-to-fork model commonly used for microbial risk assessments. The utility of the linear population model for the purpose for which it was used by CVM is discussed.
KW - antibacterial agents
KW - campylobacteriosis
KW - drug resistance
KW - epidemiology
KW - fluoroquinolones
KW - human diseases
KW - linear models
KW - poultry
KW - risk
KW - risk assessment
KW - USA
KW - Campylobacter
KW - fowls
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chickens
KW - domesticated birds
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053056834&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=risk
UR - email: mbarthol@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Model averaging using the Kullback information criterion in estimating effective doses for microbial infection and illness.
AU - Moon, H. J.
AU - Kim, H. J.
AU - Chen, J. J.
AU - Kodell, R. L.
JO - Risk Analysis
JF - Risk Analysis
Y1 - 2005///
VL - 25
IS - 5
SP - 1147
EP - 1159
CY - Boston; USA
PB - Blackwell Publishing
SN - 0272-4332
AD - Moon, H. J.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053204467. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - Since the National Food Safety Initiative of 1997, risk assessment has been an important issue in food safety areas. Microbial risk assessment is a systematic process for describing and quantifying a potential to cause adverse health effects associated with exposure to microorganisms. Various dose-response models for estimating microbial risks have been investigated. We have considered four two-parameter models and four three-parameter models in order to evaluate variability among the models for microbial risk assessment using infectivity and illness data from studies with human volunteers exposed to a variety of microbial pathogens. Model variability is measured in terms of estimated ED01s and ED10s, with the view that these effective dose levels correspond to the lower and upper limits of the 1% to 10% risk range generally recommended for establishing benchmark doses in risk assessment. Parameters of the statistical models are estimated using the maximum likelihood method. In this article a weighted average of effective dose estimates from eight two- and three-parameter dose-response models, with weights determined by the Kullback information criterion, is proposed to address model uncertainties in microbial risk assessment. The proposed procedures for incorporating model uncertainties and making inferences are illustrated with human infection/illness dose-response data sets.
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - illness
KW - infections
KW - infectious diseases
KW - infectivity
KW - mathematical models
KW - microorganisms
KW - pathogens
KW - risk assessment
KW - statistical analysis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - micro-organisms
KW - statistical methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053204467&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=risk
UR - email: hmoon@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dose-response effects of ectopic agouti protein on iron overload and age-associated aspects of the Avy/a obese mouse phenome.
AU - Wolff, G. L.
AU - Whittaker, P.
JO - Peptides
JF - Peptides
Y1 - 2005///
VL - 26
IS - 10
SP - 1697
EP - 1711
CY - New York; USA
PB - Elsevier
SN - 0196-9781
AD - Wolff, G. L.: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20053187358. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 7439-89-6. Subject Subsets: Human Nutrition
N2 - Isogenic and congenic offspring from matings of inbred black a/a dams by sibling (or non-sibling from another inbred strain) yellow agouti Avy/a sires provide an animal model of obese yellow agouti Avy/a and isogenic lean pseudoagouti Avy/a mice, exhibiting 2 different in vivo concentrations (high, very low) of ectopic agouti protein (ASP), with congenic lean black a/a mice as null controls. This makes it possible to differentiate between the high and very low dose levels of ectopic ASP with respect to interactions with diverse physiological and molecular pathways. Assay of differential responses to 12 or 24 months of carbonyl iron overload assessed the possible suitability of this animal model for the study of haemochromatosis. Agouti A/a B6C3F1 mice were used as non-congenic null controls. The age-related waxing and waning of body weight, food consumption and caloric efficiency, as well as associated changes in pancreatic islets and islet cells, and formation of liver tumours were assayed. While the hypothesis that these mice might serve as a tool for investigating haemochromatosis was not confirmed, the data did provide evidence that even the very low levels of ASP in pseudoagouti Avy/a mice affect the network of molecular/metabolic/physiological response pathways that comprises the yellow agouti obese phenome. It is suggested that the combination of yellow agouti Avy/a, pseudoagouti Avy/a and black a/a congenic mice provides a practical tool for applying a dose-response systems biology approach to understanding the dysregulatory influence of ectopic ASP on the molecular-physiological matrix of the organism.
KW - age
KW - animal models
KW - body weight
KW - caloric intake
KW - food intake
KW - haemochromatosis
KW - iron
KW - laboratory animals
KW - liver cancer
KW - metabolic disorders
KW - neoplasms
KW - obesity
KW - pancreas islets
KW - proteins
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - agouti protein
KW - cancers
KW - fatness
KW - hemochromatosis
KW - iron overload
KW - iron storage disease
KW - metabolic diseases
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053187358&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01969781
UR - email: gwolffar@prodigy.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunology of human schistosomiasis: off the beaten path.
AU - Secor, W. E.
T3 - Immunological aspects of schistosomiasis.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2005///
VL - 27
IS - 7/8
SP - 309
EP - 316
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0141-9838
AD - Secor, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20053157195. Publication Type: Journal Article. Note: Immunological aspects of schistosomiasis. Language: English. Number of References: 93 ref. Subject Subsets: Protozoology; Public Health; Tropical Diseases; Helminthology
N2 - Reviews of the immunology of human schistosomiasis generally address the host's protective responses against infection or the factors associated with development of severe pathology. However, there is a growing recognition that the high number of patients expressing moderate morbidity, rather than the few patients with severe morbidity, accounts for the greatest public health impact of schistosomiasis. Therefore, other aspects of the host immune response that have received relatively little attention may actually provide pivotal answers in our understanding and management of the morbidity associated with human schistosomiasis. This review highlights lines of investigation that focus on how immune responses to schistosomiasis may affect schistosomiasis-associated anaemia, alter susceptibility or disease progression during co-infections, and influence effective execution of mass treatment programmes.
KW - anaemia
KW - anthelmintics
KW - concurrent infections
KW - disease course
KW - drug therapy
KW - hepatitis B
KW - hepatitis C
KW - HIV-1 infections
KW - human diseases
KW - immune response
KW - immunization
KW - immunology
KW - immunopathology
KW - malaria
KW - morbidity
KW - reinfection
KW - reviews
KW - schistosomiasis
KW - susceptibility
KW - trematode infections
KW - tuberculosis
KW - vaccination
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Human immunodeficiency virus 1
KW - man
KW - Mycobacterium tuberculosis
KW - Plasmodium
KW - Schistosoma haematobium
KW - Schistosoma japonicum
KW - Schistosoma mansoni
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - anemia
KW - bacterium
KW - bilharzia
KW - bilharziasis
KW - chemotherapy
KW - disease progression
KW - fluke infections
KW - health programmes
KW - human immunodeficiency virus type 1
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - schistosomosis
KW - Strigeida
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053157195&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=pim
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Approaches in the safety evaluations of veterinary antimicrobial agents in food to determine the effects on the human intestinal microflora.
AU - Cerniglia, C. E.
AU - Kotarski, S.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 2005///
VL - 28
IS - 1
SP - 3
EP - 20
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0140-7783
AD - Cerniglia, C. E.: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053036188. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Human Nutrition
N2 - The administration of antimicrobial agents to livestock creates potential for antibiotic residues to enter the food supply and be consumed by humans. Therefore, as a process of food animal drug registration, national regulatory agencies and international committees evaluate data regarding the chemical, microbiologic, pharmacokinetic, pharmacodynamic, pharmacologic, toxicologic, and antimicrobial properties of veterinary drugs to assess the safety of ingested antimicrobial residues to consumers. Currently, European, Australian and USA guidelines for veterinary drug registration require a safety assessment of microbiologic hazards from consumption of antimicrobial residues taking into account the potentially adverse effects on human intestinal microflora. The main concerns addressed are selection of resistant bacteria in the gastrointestinal tract and disruption of the colonization barrier of the resident intestinal microflora. Current requirements differ among national agencies. Efforts are ongoing internationally to review and harmonize approaches and test methods and protocols for application to these microbiologic safety evaluations of antimicrobial drug residues in food. This review describes the background to current regulatory approaches used in applying in vitro and in vivo methods to set a microbiologic acceptable daily intake for residues in food derived from animals treated with an antimicrobial agent. This paper also examines the current research needs to support these evaluations.
KW - antiinfective agents
KW - drug residues
KW - food safety
KW - in vitro
KW - intestines
KW - livestock
KW - microbial flora
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - in vivo
KW - microflora
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Nutrition (General) (VV100)
KW - Microbiology (General) (ZZ390)
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UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jvp
UR - email: ccerniglia@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preparative HPLC for purification of four isomeric bioactive saponins from the seeds of Aesculus chinensis.
AU - Wei Feng
AU - Ma LinYun
AU - Cheng XianLong
AU - Lin RuiChao
AU - Jin, W. T.
AU - Khan, I. A.
AU - Lu JianQiu
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 2005///
VL - 28
IS - 5
SP - 763
EP - 773
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1082-6076
AD - Wei Feng: Division of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, 2 Tiantan Xili, Beijing 100050, China.
N1 - Accession Number: 20053053891. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Seed Science; Horticultural Science; Ornamnental Horticulture; Aromatic & Medicinal Plants
N2 - Four isomeric bioactive saponin compounds named escin Ia, isoescin Ia, escin Ib, and isoescin Ib were successfully isolated and purified from the crude extract of the seeds of a traditional chinese medicinal plant Aesculus chinensis Bge (Hippocastanaceae) by preparatory high performance liquid chromatography (Pre-HPLC). The gradient mobile phase solvent system composed of methanol-water-acetic acid was employed. An efficient large scale preparatory method was developed based on the stability investigation of escin Ia for the first time. A total amount of 5.2 g escin Ia, 2.8 g isoescin Ia, 3.8 g escin Ib, and 1.6 g isoescin Ib, separately, over 99% purity was obtained from 50 g of total saponins. The preparatory purification of four isomeric saponins by Pre-HPLC was completed in 120 min in a one step separation.
KW - analgesics
KW - chemical composition
KW - HPLC
KW - medicinal plants
KW - methodology
KW - plant composition
KW - plant extracts
KW - purification
KW - saponins
KW - seeds
KW - traditional medicines
KW - China
KW - Aesculus
KW - Hippocastanaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Aesculus
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Aesculus chinensis
KW - chemical constituents of plants
KW - drug plants
KW - high performance liquid chromatography
KW - medicinal herbs
KW - methods
KW - officinal plants
KW - pain killers
KW - People's Republic of China
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053053891&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102597
UR - email: hograwei@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Understanding prevention effectiveness in real-world settings: the National Cross-Site Evaluation of high risk youth programs.
AU - Sambrano, S.
AU - Springer, J. F.
AU - Sale, E.
AU - Kasim, R.
AU - Hermann, J.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 2005///
VL - 31
IS - 3
SP - 491
EP - 513
CY - New York; USA
PB - Taylor & Francis
SN - 0095-2990
AD - Sambrano, S.: Center for Substance Abuse Prevention, Rockville, Maryland, USA.
N1 - Accession Number: 20063047335. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - The National Cross-Site Evaluation is a large multisite evaluation (MSE) of 48 substance abuse prevention programs, 5,934 youth participating in programs, and 4,539 comparison youth programs. Data included a self-report questionnaire administered at 4 points in time, detailed dosage data on over 217,000 program contacts, and detailed site visit information. In a pooled analysis, the programs did not demonstrate significant positive effects on a composite outcome measure of tobacco, alcohol, and marijuana use in the previous 30 days. However, disaggregated analyses indicated that (1) sites in which comparison groups had strong opportunity to participate in prevention programs suppressed observed effects; (2) youth who had already started using before they entered programs reduced use significantly more than comparison youth who had started using; and (3) both males and females who participated in programs significantly reduced use relative to comparisons, but in very different patterns. Combining these patterns produced an apparent null effect. Finally, programs that incorporated at least 4 out of 5 effective intervention characteristics identified in the study significantly reduced use for both males and females relative to comparison youth. The lessons produced by this study attest to the value of MSE designs as a source of applicable knowledge about prevention interventions.
KW - alcohol intake
KW - boys
KW - children
KW - girls
KW - prevention
KW - risk groups
KW - substance abuse
KW - tobacco smoking
KW - youth
KW - youth programmes
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alcohol consumption
KW - youth programs
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063047335&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/(y3lsl4z10yoklo45vtx0tnao)/app/home/contribution.asp?referrer=parent&backto=issue,9,10;journal,3,29;browsepublicationsresults,43,1268;
UR - email: fred@emt.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved ELISA test for determination of potency of Inactivated Poliovirus Vaccine (IPV).
AU - Rezapkin, G.
AU - Dragunsky, E.
AU - Chumakov, K.
JO - Biologicals
JF - Biologicals
Y1 - 2005///
VL - 33
IS - 1
SP - 17
EP - 27
CY - London; UK
PB - Elsevier Science Ltd
SN - 1045-1056
AD - Rezapkin, G.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA.
N1 - Accession Number: 20053051652. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 308067-58-5.
N2 - An improved ELISA test for determination of potency of Inactivated Poliovirus Vaccine (IPV) is proposed. The method is based on the use of IgG purified from immune rabbit serum conjugated with biotin. Optimized and validated materials for the test can be stored for a long time in the form of ready-to-use kits. Optimization included selection of anti-poliovirus rabbit antibody batches with the best specificity to D-antigen as well as finding the most efficient parameters for all steps of ELISA protocol. The assay is based on direct ("sandwich") ELISA scheme, in which antigens are captured on ELISA plates coated with purified rabbit polyclonal D-antigen specific IgG raised against wild polioviruses of three serotypes. D-antigen specificity of the IgG was at least 10 times higher than to H-antigen (heat-inactivated virus). The presence of antigen was detected using biotin-conjugated IgG from the same source. Eight-point dose-response curves were obtained for each sample and the reference vaccine. The protocol ensured low background (less than 0.2 OD), linear response over the entire range of optical density measurements (up to 3.0 OD), and high precision of data (assay variability was about 3%). The quantitative results and the validity of the test were determined by two numerical approaches, linear regression and a new analysis procedure called the local interpolation method. For the first approach we also proposed a new method for testing of parallelism of regression lines. The ELISA protocol for all three types of poliovirus is based on standard off-the-shelf reagents, and is highly reproducible and reliable. An in-house Reference Reagent was formulated and calibrated against the International Reference for IPV.
KW - antibodies
KW - ELISA
KW - IgG
KW - immunization
KW - inactivated vaccines
KW - laboratory animals
KW - poliomyelitis
KW - potency
KW - vaccination
KW - viral antigens
KW - Poliovirus
KW - rabbits
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Leporidae
KW - Lagomorpha
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - enzyme linked immunosorbent assay
KW - human poliovirus
KW - immune sensitization
KW - killed vaccines
KW - polio
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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UR - http://www.sciencedirect.com/science/journal/10451056
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of antigenic profiles of inactivated poliovirus vaccine and vaccine-derived polioviruses by block-ELISA method.
AU - Rezapkin, G.
AU - Martin, J.
AU - Chumakov, K.
JO - Biologicals
JF - Biologicals
Y1 - 2005///
VL - 33
IS - 1
SP - 29
EP - 39
CY - London; UK
PB - Elsevier Science Ltd
SN - 1045-1056
AD - Rezapkin, G.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA.
N1 - Accession Number: 20053051653. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - A new block-ELISA test for quantitative evaluation of relative reactivity of antigenic sites was developed and used to reveal the detailed epitope structure of inactivated poliovirus vaccines (IPV) and live poliovirus strains. Poliovirus was captured on ELISA plates coated with rabbit anti-poliovirus IgG and blocked by monoclonal antibodies (Mabs) specific to individual epitopes before the remaining reactive antigenic sites were quantified by polyclonal anti-poliovirus IgG conjugate. The decrease of conjugate binding by the pre-treatment with a Mab reflects its contribution to the overall reactivity of poliovirus antigen. The level of block activity of Mabs for a given antigen can be expressed as a percent of reduction of antigenic reactivity as determined by ELISA test. It can be normalized by expressing this value as a ratio to the block activity of a reference sample. The data on the blocking-activity of a panel of monoclonal antibodies specific to different antigenic sites represents the epitope composition (antigenic profile) of a sample. Quantitative differences in epitope composition were determined for nine samples of inactivated poliovirus vaccine (IPV) and compared with the International Reference Reagent. This method could be used for monitoring consistency of IPV production, comparison of vaccines made by different manufacturers, and for the analysis of antigenically modified strains of attenuated poliovirus. Antigenic structures of two isolates of type 1 vaccine-derived poliovirus (VDPV) were compared with the structures of parental Sabin 1 and wild-type Mahoney strains using 17 monoclonal antibodies and revealed significant differences, suggesting that the method can be used for screening of field isolates and rapid identification of antigenically divergent VDPV strains.
KW - antibodies
KW - ELISA
KW - epitopes
KW - IgG
KW - inactivated vaccines
KW - monoclonal antibodies
KW - poliomyelitis
KW - viral antigens
KW - Poliovirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenic determinants
KW - enzyme linked immunosorbent assay
KW - human poliovirus
KW - killed vaccines
KW - polio
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053051653&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10451056
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Absolute stroke mortality burden for non-Hispanic non-Latino whites was disproportionately higher than expected simply based on the US population in 2001.
AU - Fields, L. E.
JO - Stroke
JF - Stroke
Y1 - 2005///
VL - 36
IS - 5
SP - e48
EP - e49
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0039-2499
AD - Fields, L. E.: Office of Public Health and Science of the Office of the Secretary, US Department of Health and Human Services, 200 Independence Ave, Washington, DC 20201, USA.
N1 - Accession Number: 20053085951. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background and Purpose - The absolute burden of stroke is a major determinant of health care costs and should also be considered when developing and implementing effective health policy. This study evaluated the impact of specific racial-ethnic categorization on absolute stroke mortality burden and population percentages. Methods - In this population-based analysis, 2001 US data was used to compute absolute values of population and stroke mortality burden for white and black, and other racial-ethnic groups. To test the effect of age-mix, values were age-adjusted using the 2000 US standard population. The z test statistic was computed and a 2-tailed P value of <0.05 was considered significant. Result - Whites comprised a majority of the 2001 absolute US stroke mortality burden and US population (86% and 82%, respectively). Surprisingly, nHnL whites comprised a much higher percentage of the absolute US stroke mortality burden than expected based on their percentage of the US population alone (81% and 69%, respectively; P<0.001). Age-adjustment indicated a contribution by age-mix, however, an age-independent residual component remained. Conclusions - Specific race-ethnicity categorization significantly influences comparisons of the proportion of absolute stroke mortality burden to the population proportion. Accordingly, appropriate caution and care are needed when estimating the societal impact of conditions such as stroke.
KW - blacks
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - human diseases
KW - mortality
KW - stroke
KW - whites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - ethnic differences
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053085951&site=ehost-live&scope=site
UR - http://stroke.ahajournals.org/cgi/content/abstract/36/5/e48
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multigenerational exposure to genistein does not increase bone mineral density in rats.
AU - Hotchkiss, C. E.
AU - Weis, C.
AU - Blaydes, B.
AU - Newbold, R.
AU - Delclos, K. B.
JO - Bone (New York)
JF - Bone (New York)
Y1 - 2005///
VL - 37
IS - 5
SP - 720
EP - 727
CY - New York; USA
PB - Elsevier
SN - 8756-3282
AD - Hotchkiss, C. E.: The Bionetics Corporation, BIO-915, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20063116500. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Registry Number: 446-72-0. Subject Subsets: Human Nutrition
N2 - Genistein has been shown to prevent bone loss in ovariectomized adult rats. However, the effects of genistein on bone in developing and reproductively-intact rats have not been examined. A large multigenerational experiment involved feeding 0, 5, 100, or 500 ppm genistein in the diet to intact male and female rats from conception until either weaning, postnatal day 140, or continuously for 2 years. Vertebrae (lumbar and caudal) were collected from these animals at necropsy at 2 years of age and subjected to dual-energy x-ray absorptiometry (DXA) scanning to measure bone mineral density (BMD), bone mineral content (BMC), and bone area. Femurs were collected, and length, cross-sectional area, and cortical bone area were measured directly. Serum was collected for measurement of pyridinoline (PYD) and alkaline phosphatase (ALP). BMD was not affected by genistein in any phase of the experiment. In female rats treated continuously with genistein, BMC and bone area were reduced in the 500 ppm group compared to the 5 ppm group in the lumbar vertebrae, and in all treatment groups compared to control in the caudal vertebrae. In both males and females treated continuously, the cross-sectional area of the femur was reduced in rats treated with 500 ppm compared to those treated with 5 ppm. In female rats treated continuously, PYD was higher in the 100 and 500 ppm groups than in the 0 and 5 ppm groups. In conclusion, the effects of genistein on reproductively-intact rats were not dramatic. High dose of genistein throughout the lifespan resulted in decreased bone size, which may reduce the force required to break the bone.
KW - animal models
KW - bone density
KW - diets
KW - femur
KW - genistein
KW - laboratory animals
KW - osteoporosis
KW - spine
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063116500&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4Y-4GV9SJJ-1&_user=3891418&_handle=V-WA-A-W-AZ-MsSAYVA-UUW-U-AACBEWDDVA-AACACUYCVA-EZAAVADZZ-AZ-U&_fmt=summary&_coverDate=11%2F30%2F2005&_rdoc=15&_orig=browse&_srch=%23toc%234987%232005%23999629994%23608619!&_cdi=4987&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=0b749f1fb3f5d79076bae5a18d141bdc
UR - email: chotchkiss@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Fertility regulation and systemic hormones in HIV-infected and at-risk women. Proceedings of a conference held near Washington, DC, USA, January 13-15, 2003.
AU - Veronese, F.
AU - Reichelderfer, P.
A2 - Veronese, F.
A2 - Reichelderfer, P.
T2 - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005///
VL - 38
SP - S1
EP - S52
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Veronese, F.: Office of AIDS Research, Office of the Director, National Institutes of Health, US Department of Health and Human Services, USA.
N1 - Accession Number: 20053090392. Publication Type: Journal issue; Conference proceedings. Language: English. Subject Subsets: Public Health
N2 - This issue contains 27 papers presented at the conference. The papers are divided into the following parts: (I) contraceptive choices for HIV-infected and at-risk women (4 papers); (II) hormonal influences on HIV acquisition (5); (III) hormonal influence on HIV disease and co-morbidities (4); (IV) hormonal influence on treatment and the effect of treatments on contraceptive methods (3); (V) hormonal influence on changes in genital tract virological/immunological parameters and implications for transmission (5); (VI) the role of artificial insemination in HIV-discordant couples (1); (VII) the role of hormonal menopausal therapy in HIV-infected and at-risk women (2). Part I presents the different types of contraception that are available, including different types of applications, and what the impact of application type is on drug delivery. In addition, the types of contraception being used both nationally and internationally in HIV-infected and uninfected populations are reviewed. In part II, methods that prevent HIV acquisition are reviewed. The possibility of increased HIV acquisition with the use of hormonal contraceptives is discussed from the biological plausibility of membrane thinning in both the animal model systems and in women and the upregulation of HIV co-receptors. Data are presented from studies in which hormones appear to influence HIV acquisition, and the ongoing prospective trial of hormonal use and HIV acquisition is described. In part III, the effect of hormonal contraceptives and their influence on the natural history of HIV disease from international studies is discussed, as well as the impact of hormonal contraceptive use and participation in clinical trials of antiretroviral therapy. Finally, data are presented on the impact of endogenous hormone changes on CD4 cell counts. Part IV begins with a basic overview of pharmacology in terms of metabolism and transport systems, in order to provide a basic understanding for the reactions between various drugs including hormonal contraceptives and antiretroviral agents. This basic introduction was followed by more detailed information from the US Food and Drug Administration, clinical trials and cohort studies. Finally, a summary of how to handle these interactions is presented of present CDC recommendations and the French Guidelines. An overview of the potential source of the virus in the female genital tract and issues regarding measurement of the virus was first presented in part V. This was followed by a presentation on the effect of both endogenous hormonal changes, including pregnancy, and then exogenous hormonal influence on both virological and immunological parameters. In part VI, the importance of child-bearing for HIV at-risk and infected women is elaborated. The difficulties in meeting this need safely and the attitudes of healthcare providers towards providing that need are discussed. Part VII focuses on the unique issue of menopausal HIV-infected patients and what are the risks/benefits of hormonal replacement therapy to them.
KW - acquisition
KW - animal models
KW - antiretroviral agents
KW - antiviral agents
KW - artificial insemination
KW - attitudes
KW - CD4+ lymphocytes
KW - clinical trials
KW - contraception
KW - contraceptives
KW - disease transmission
KW - drug metabolism
KW - drug therapy
KW - female genitalia
KW - fertility
KW - guidelines
KW - health care workers
KW - HIV infections
KW - hormone replacement therapy
KW - human diseases
KW - human immunodeficiency viruses
KW - immunology
KW - leukocyte count
KW - menopause
KW - pharmacology
KW - pregnancy
KW - risk factors
KW - risk groups
KW - sex hormones
KW - sexually transmitted diseases
KW - susceptibility
KW - viral diseases
KW - women
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AI
KW - birth control
KW - CD4+ cells
KW - cell count
KW - chemotherapy
KW - comorbidity
KW - female genital system
KW - gestation
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - recommendations
KW - STDs
KW - T4 lymphocytes
KW - venereal diseases
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Women (UU500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Data from the United States Food and Drug Administration.
AU - Zheng, J. H.
A2 - Veronese, F.
A2 - Reichelderfer, P.
JO - JAIDS, Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS, Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005///
VL - 38
SP - S24
EP - S26
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1525-4135
AD - Zheng, J. H.: US Food and Drug Administration, DHHS, Rockville, Maryland, USA.
N1 - Accession Number: 20053090399. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - The pharmacokinetic/pharmacodynamic effect of antiretroviral drugs on oral contraceptives (OCs) is discussed. The marketed HIV-related drugs that reduce OC plasma concentrations are summarized. The geometric mean increase in OC plasma concentrations caused by the co-administration of marketed HIV-related drugs is outlined. It is concluded that OCs are widely used by HIV-infected women to prevent pregnancy. Because of the multitude of drugs they are taking, potential drug-drug interactions between OCs and other drugs (e.g. antiretroviral drugs) may affect the efficacy/safety of OCs and highly active antiretroviral therapy drugs.
KW - antiretroviral agents
KW - antiviral agents
KW - contraception
KW - drug metabolism
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - oral contraceptives
KW - pharmacodynamics
KW - pharmacokinetics
KW - viral diseases
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - birth control
KW - chemotherapy
KW - drug action
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mechanism of drug action
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Relative retention order of all isomers of cis/trans conjugated linoleic acid FAME from the 6,8- to 13,15-positions using silver ion HPLC with two elution systems.
AU - Delmonte, P.
AU - Kataoka, A.
AU - Corl, B. A.
AU - Bauman, D. E.
AU - Yurawecz, M. P.
JO - Lipids
JF - Lipids
Y1 - 2005///
VL - 40
IS - 5
SP - 509
EP - 514
CY - Champaign; USA
PB - AOCS Press
SN - 0024-4201
AD - Delmonte, P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20053143324. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 60-33-3, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition
N2 - Conjugated linoleic acid (CLA), defined as one or more octadecadienoic acids (18:2) with conjugated double bonds, has been reported to be active in a number of biological systems. Gas chromatography (GC) and silver ion high performance liquid chromatography (HPLC; Ag+-HPLC) have been the primary techniques for identifying specific CLA isomers in both foods and biological extracts. Recently, GC relative retention times were reported for all c,c, c/t (c,t and t,c), and t,t CLA FAME from the 6,8- to the 13,15-positions in octadecadienoic acid (18:2). Presented here is the relative retention order of the same CLA FAME using Ag+-HPLC with two different elution systems. The first elution system, consisting of 0.1% acetonitrile/0.5% diethyl ether/hexane, has been used previously to monitor CLA composition in foods. Also presented here is the retention order of CLA FAME using 2% acetic acid/hexane elution solvent, which has advantages of more stable retention volume (RV) and a complementary elution order of CLA FAME isomers. The data are reported using RV adjusted for toluene, an estimator for dead volume, and relative to c9,t11-18:2. Measurement of relative RV in the analysis of 88 samples of cow plasma, milk, and rumen fluids using Ag+-HPLC is also presented here. The % coefficient of variation ranged from 1.04 to 1.62 for t,t isomers and from 0 to 0.48 for c/t isomers.
KW - analytical methods
KW - conjugated linoleic acid
KW - foods
KW - gas chromatography
KW - HPLC
KW - isomers
KW - linoleic acid
KW - analytical techniques
KW - high performance liquid chromatography
KW - octadecadienoic acid
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053143324&site=ehost-live&scope=site
UR - email: mpy@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Health effects classification and its role in the derivation of minimal risk levels: reproductive and endocrine effects.
AU - Pohl, H. R.
AU - Luukinen, B.
AU - Holler, J. S.
T2 - Regulatory Toxicology and Pharmacology
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2005///
VL - 42
IS - 2
SP - 209
EP - 217
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Pohl, H. R.: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20053131470. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. From the total of 326 MRLs currently posted on ATSDR's web site (www.atsdr.cdc.gov), 14 and 5 MRLs are based on reproductive and endocrine endpoints, respectively. The paper also describes the ranking of effects into less serious and serious categories according to ATSDR's Guidance for Developing Toxicological Profiles, endpoints used for the MRLs derivation, and the use of uncertainty factors.
KW - endocrine system
KW - public health
KW - reproduction
KW - risk assessment
KW - toxic substances
KW - toxicity
KW - toxicology
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - poisons
KW - United States of America
KW - Health Services (UU350)
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053131470&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4G7NT5P-2&_user=10&_coverDate=07%2F31%2F2005&_rdoc=9&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236999%232005%23999579997%23599187%23FLA%23display%23Volume)&_cdi=6999&_sort=d&_docanchor=&view=c&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f28990009d4e9d4b7c2174fbefefa4d3
UR - email: hpohl@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The use of structure-activity relationship analysis in the food contact notification program.
AU - Bailey, A. B.
AU - Chanderbhan, R.
AU - Collazo-Braier, N.
AU - Cheeseman, M. A.
AU - Twaroski, M. L.
T2 - Regulatory Toxicology and Pharmacology
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2005///
VL - 42
IS - 2
SP - 225
EP - 235
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Bailey, A. B.: Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA.
N1 - Accession Number: 20053131471. Publication Type: Journal Article. Language: English.
N2 - Food contact substances (FCS) include polymers, paper and paperboard, and substances used in their manufacture, that do not impart a technical effect on food. Moreover, FCSs are industrial chemicals generally consumed at dietary concentrations (DC) of less than 1 mg/kg food (ppm), and more commonly at less than 0.05 ppm (50 ppb), in the daily diet. As such, many industrial chemicals have been analyzed for toxicological concern, some of which may share structural similarity with FCSs or their constituents, and the majority of these studies are available in the public domain. The DCs of these compounds lend themselves to using structure-activity relationship (SAR) analysis, as the available "expert systems" and use of analogs allows for prediction and management of potential carcinogens. This paper describes the newly implemented food contact notification (FCN) program, the program by which FDA reviews FCSs for safe use, the administrative review of FCSs, the SAR tools available to FDA, and qualitative and quantitative risk assessments using SAR analysis within the regulatory framework of reviewing the safety of FCSs.
KW - food contamination
KW - food safety
KW - packaging materials
KW - paper
KW - paperboard
KW - polymers
KW - structure activity relationships
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053131471&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4G9GNRT-1&_user=10&_coverDate=07%2F31%2F2005&_rdoc=11&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236999%232005%23999579997%23599187%23FLA%23display%23Volume)&_cdi=6999&_sort=d&_docanchor=&view=c&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e4b1021c3f6c2ddbb720d70c0ef40d18
UR - email: Michelle.Twaroski@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Demystifying 21 CFR Part 556 - tolerances for residues of new animal drugs in food.
AU - Brynes, S. D.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2005///
VL - 42
IS - 3
SP - 324
EP - 327
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Brynes, S. D.: Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20053169296. Publication Type: Journal Article. Language: English. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - 21 Code of Federal Regulations Part 556 (Tolerances for Residues of New Animal Drugs in Foods) is one of the Center for Veterinary Medicine's most significant set of regulations. However, in many respects, it is outdated. Subpart A (General Provisions) defines tolerance designations that are obsolete, while Subpart B (Specific Tolerances for Residues of New Animal Drugs) is inconsistent in terminology and often confusing. The purpose of this paper is to define the older terms and update the reader as to current concepts that apply to tolerance-setting for new animal drugs. A list of useful definitions appears at the end of the article.
KW - drug residues
KW - feeds
KW - tolerance
KW - veterinary medicine
KW - veterinary products
KW - animals
KW - eukaryotes
KW - animal health products
KW - feeding stuffs
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
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UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4GKW7F5-1&_user=3891418&_handle=V-WA-A-W-AU-MsSWYWW-UUA-U-AABAADAUWV-AAWYDCAYWV-BYCDWVUED-AU-U&_fmt=full&_coverDate=08%2F31%2F2005&_rdoc=9&_orig=browse&_srch=%23toc%236999%232005%23999579996%23602637!&_cdi=6999&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=cae1161255b269636304e2c050412d68
UR - email: sbrynes@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of novel compounds for pest control: insecticidal and acaricidal activity of essential oil components from heartwood of Alaska yellow cedar.
AU - Panella, N. A.
AU - Dolan, M. C.
AU - Karchesy, J. J.
AU - Xiong, Y. P.
AU - Peralta-Cruz, J.
AU - Khasawneh, M.
AU - Montenieri, J. A.
AU - Maupin, G. O.
JO - Journal of Medical Entomology
JF - Journal of Medical Entomology
Y1 - 2005///
VL - 42
IS - 3
SP - 352
EP - 358
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-2585
AD - Panella, N. A.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053117090. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Botanical Pesticides; Medical & Veterinary Entomology; Aromatic & Medicinal Plants; Public Health
N2 - Laboratory bioassays were conducted to determine the activity of 15 natural products isolated from essential oil components extracted from the heartwood of Alaska yellow cedar, Chamaecyparis nootkatensis, against Ixodes scapularis nymphs, Xenopsylla cheopis, and Aedes aegypti adults. Four of the compounds from the essential oil have been identified as monoterpenes, five as eremophilane sesquiterpenes, five as eremophilane sesquiterpene derivatives from valencene and nootkatone, and one as a sesquiterpene outside the eremophilane parent group. Carvacrol was the only monoterpene that demonstrated biocidal activity against ticks, fleas, and mosquitoes, with LC50 values after 24 h of 0.0068%, 0.0059% and 0.0051% (wt:vol), respectively. Nootkatone from Alaska yellow cedar was the most effective of the eremophilane sesquiterpenes against ticks (LC50=0.0029%), whereas the nootkatone grapefruit extract exhibited the greatest biocidal activity against fleas (LC50=0.0029%). Mosquitoes were most susceptible to one of the derivatives of valencene, valencene-13-aldehyde (LC0=0.0024%), after 24 h. Bioassays to determine residual activity of the most effective products were conducted at 1, 2, 4 and 6 weeks after initial treatment. Residual LC50 values for nootkatone did not differ significantly at 4 weeks posttreatment from the observations made at the initial 24-h treatment. The ability of these natural products to kill arthropods at relatively low concentrations represents an alternative to the use of synthetic pesticides for control of disease vectors.
KW - acaricidal properties
KW - botanical insecticides
KW - botanical pesticides
KW - disease vectors
KW - essential oils
KW - human diseases
KW - insecticidal properties
KW - monoterpenes
KW - nymphs
KW - residual effects
KW - sesquiterpenes
KW - vector control
KW - vector-borne diseases
KW - Aedes aegypti
KW - Culicidae
KW - Ixodes scapularis
KW - Xanthocyparis nootkatensis
KW - Xenopsylla cheopis
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Xanthocyparis
KW - Cupressaceae
KW - Pinopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - Xenopsylla
KW - Pulicidae
KW - Siphonaptera
KW - Chamaecyparis nootkatensis
KW - mosquitoes
KW - nootka cypress
KW - Oriental rat flea
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice.
AU - Beland, F. A.
AU - Benson, R. W.
AU - Mellick, P. W.
AU - Kovatch, R. M.
AU - Roberts, D. W.
AU - Fang, J. L.
AU - Doerge, D. R.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 1
SP - 1
EP - 19
CY - Amsterdam; Netherlands
PB - Elsevier Ltd
SN - 0278-6915
AD - Beland, F. A.: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053020665. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 9035-51-2, 64-17-5, 51-79-6. Subject Subsets: Dairy Science; Human Nutrition
N2 - Urethane is a carcinogen to which there is widespread exposure through the consumption of fermented foods and alcoholic beverages. In this study, we have assessed the carcinogenicity of urethane in combination with ethanol. Male and female B6C3F1 mice (48 mice per sex per group) were exposed to 0, 10, 30, or 90 ppm urethane in the presence of 0%, 2.5%, or 5% ethanol in drinking water ad libitum for two years, at which time the extent of tumorigenesis was assessed. Additional mice (four per sex per group) received the same doses for four weeks to assess serum levels of urethane and ethanol, DNA adduct formation, and the induction of microsomal cytochromes P450, cell proliferation, and apoptosis. Urethane decreased cell replication in the livers of female, but not male, mice, decreased cell replication in the lungs of both sexes, and induced cytochrome P450 2E1 in the livers of female mice. Hepatic levels of the DNA adduct 1, N6-ethenodeoxyadenosine were increased by exposure to urethane and decreased by treatment with ethanol. Animal weights and survival were not affected by ethanol; in contrast, urethane administration decreased body weights and survival. Urethane caused dose-dependent increases in liver, lung, and harderian gland adenoma or carcinoma and hemangiosarcoma of the liver and heart in both sexes, mammary gland and ovarian tumors in females, and squamous cell papilloma or carcinoma of the skin and forestomach in males. The increase in hepatocellular tumors occurred in a relatively linear manner and was attributed to the formation of 1, N6-ethenodeoxyadenosine in hepatic DNA coupled with an increase in cell replication. Hemangiosarcomas were observed only at the 90 ppm urethane dose and were probably a result of high-dose urethane-induced toxicity. Lung alveolar/bronchiolar and harderian gland adenoma or carcinoma increased in a relatively linear manner, suggestive of a genotoxic mechanism for tumor induction. Ethanol induced a dose-dependent trend in hepatocellular adenoma or carcinoma in male mice, with the incidence being marginally increased at the highest dose. In female mice administered 10 ppm and 90 ppm urethane, ethanol caused dose-related increases in alveolar/bronchiolar adenoma or carcinoma and hemangiosarcoma of the heart, respectively. This may be due to ethanol decreasing the first-pass clearance of urethane, thus, increasing systemic distribution. In male mice a different relationship was observed: ethanol caused a dose-related decrease in alveolar/bronchiolar and harderian gland adenoma or carcinoma in mice administered 30 ppm urethane.
KW - animal models
KW - carcinogenesis
KW - carcinogens
KW - cytochrome P-450
KW - ethanol
KW - heart
KW - human diseases
KW - laboratory animals
KW - liver
KW - mammary glands
KW - neoplasms
KW - ovaries
KW - urethane
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - ethyl alcohol
KW - ethyl carbamate
KW - ethylurethane
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053020665&site=ehost-live&scope=site
UR - email: fbeland@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic typing of the porin protein of Neisseria gonorrhoeae from clinical noncultured samples for strain characterization and identification of mixed gonococcal infections.
AU - Lynn, F.
AU - Hobbs, M. M.
AU - Zenilman, J. M.
AU - Behets, F. M. T. F.
AU - Damme, K. van
AU - Rasamindrakotroka, A.
AU - Bash, M. C.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 1
SP - 368
EP - 375
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Lynn, F.: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Bethesda, MD 20852, USA.
N1 - Accession Number: 20063059915. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Tropical Diseases
N2 - Molecular methods that characterize the Neisseria gonorrhoeae porin protein Por are needed to study gonococcal pathogenesis in the natural host and to classify strains from direct clinical samples used with nucleic acid amplification-based tests. We have defined the capabilities of por variable region (VR) typing and determined suitable conditions to apply the method to direct clinical specimens. Nested PCR from spiked urine samples detected 1 to 10 copies of template DNA; freezing spiked whole urine greatly reduced the ability to amplify porB. In a laboratory model of mixed gonococcal infections, the por type of one strain could be determined in the presence of a 100-fold excess of another. por VR typing was used to examine clinical samples from women enrolled in studies conducted in Baltimore, Md., and Madagascar. por type was determined from 100% of paired cervical swab and wick samples from 20 culture-positive women from Baltimore; results for eight individuals (40%) suggested infection with more than one strain. In frozen urine samples from Madagascar, porB was amplified and typed from 60 of 126 samples from ligase chain reaction (LCR)-positive women and 3 samples from LCR-negative women. The por VR types of 13 samples (21%) suggested the presence of more than one gonococcal strain. Five por types, identified in >45% of women with typed samples, were common to both geographic areas. Molecular typing is an important adjunct to nucleic acid amplification-based diagnostics. Methods that utilize direct clinical samples and can identify mixed infections may contribute significantly to studies of host immunity, gonococcal epidemiology, and pathogenesis.
KW - bacterial diseases
KW - bacterial proteins
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - mixed infections
KW - urine
KW - women
KW - Madagascar
KW - Maryland
KW - man
KW - Neisseria gonorrhoeae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - East Africa
KW - Africa South of Sahara
KW - Africa
KW - Francophone Africa
KW - Indian Ocean Islands
KW - Least Developed Countries
KW - Developing Countries
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Malagasy Republic
KW - multiple infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063059915&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/43/1/368
UR - email: bash@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatotoxicity of androstenedione in pregnant rats.
AU - Sahu, S. C.
AU - Sapienza, P. P.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Ross, I. A.
AU - Flynn, T. J.
AU - Wiesenfeld, P. L.
AU - O'Donnell, M. W.
AU - Kim, C. S.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 2
SP - 341
EP - 344
CY - Amsterdam; Netherlands
PB - Elsevier Ltd
SN - 0278-6915
AD - Sahu, S. C.: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, MOD-1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053018511. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9000-86-6, 63-05-8, 9000-97-9, 70-18-8, 50812-37-8, 9001-60-9. Subject Subsets: Human Nutrition
N2 - Androstenedione, a naturally occurring steroid hormone, is a dietary supplement used to enhance athletic performance. Little is known, however, about the safety of its use by young adults including women of child bearing age. To test the possible hepatotoxic effects of androstenedione use, this study was undertaken using a rat model. Pregnant rats (six rats/dose) were exposed to androstenedione in corn oil by gastric intubation at 0, 5, 30 or 60 mg/kg body weight/day beginning 2 weeks before mating and continuing through gestation day 19. On gestation day 20, blood and livers were collected from the pregnant rats for analysis of hepatotoxicity endpoints: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), glutathione (GSH) and glutathione S-transferase (GST), total microsomal P450, nuclear DNA damage and lipid peroxidation. Under these experimental conditions, no significant differences were observed in any of these biomarkers over the concentration range examined.
KW - alanine aminotransferase
KW - androstenedione
KW - animal models
KW - aspartate aminotransferase
KW - biochemical markers
KW - glutathione
KW - glutathione transferase
KW - laboratory animals
KW - lactate dehydrogenase
KW - lipid peroxidation
KW - liver
KW - pregnancy
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biomarkers
KW - gestation
KW - glutamate pyruvate transaminase
KW - glutamic pyruvic transaminase
KW - GOT
KW - GPT
KW - hepatotoxicity
KW - ligandin
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053018511&site=ehost-live&scope=site
UR - email: ssahu@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of the effect of deoxynivalenol on selected male reproductive endpoints.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Black, T. N.
AU - Olejnik, N.
AU - Rorie, J. I.
AU - Eppley, R. M.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 4
SP - 623
EP - 635
CY - Amsterdam; Netherlands
PB - Elsevier Ltd
SN - 0278-6915
AD - Sprando, R. L.: Food and Drug Administration, Developmental and Reproductive Toxicology Branch, Division of Toxicology and Nutritional Product Studies, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053049835. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 9002-68-0, 9002-67-9, 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8, 15262-86-9, 51481-10-8. Subject Subsets: Medical & Veterinary Mycology
N2 - The effect of deoxynivalenol (DON) exposure on male reproductive function was assessed in the rat. Male rats were divided into a control group (n=15 rats) and four treatment groups (0.5 mg/kg, n=15; 1.0 mg/kg, n=15; 2.5 mg/kg, n=15; and 5.0 mg/kg DON, n=16) and exposed to DON daily for 28 days via gastric intubation. Both body weight gain and the final body weight of animals in the 5.0 mg/kg dose group and feed consumption in animals in the 2.5 mg/kg and 5.0 mg/kg dose groups were significantly reduced compared to controls. Fluid consumption was not affected in any of the treated groups. Epididymal and seminal vesicle weights expressed per gram of body weight and brain weight were significantly reduced, compared to control weights, in animals from the 2.5 and 5.0 mg/kg dose groups while prostate weight expressed per gram of brain weight and body weight was significantly lower than controls only in the 5.0 mg/kg dose group. A statistically significant, dose-related decrease in homogenization resistant testicular spermatid counts, spermatid numbers, absolute cauda epididymal sperm numbers and cauda epididymal sperm numbers per gram of cauda epididymis was observed in the 5.0 mg/kg DON treatment group. Sperm tail abnormalities (broken tails) in the 5.0 mg/kg dose group were significantly higher than in the control group. Sperm swimming speed (VSL and VCL) was significantly increased only in the 2.5 mg/kg dose group. Serum FSH and LH concentrations were increased in a dose dependent manner across all treated groups while serum testosterone concentrations were decreased in a dose-related manner across all dose groups. An increase in germ cell degeneration, sperm retention and abnormal nuclear morphology was observed in the 2.5 mg/kg and 5.0 mg/kg dose groups. Treatment related effects included lesions in the non-glandular stomach, thymic lymphoid depletion and splenic hematopoiesis in the 5.0 mg/kg treatment group.
KW - animal models
KW - body weight
KW - brain
KW - epididymis
KW - FSH
KW - LH
KW - males
KW - mycotoxins
KW - reproduction
KW - spermatogenesis
KW - spermatozoa
KW - testes
KW - testosterone
KW - vesicular gland
KW - vomitoxin
KW - weight gain
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - deoxynivalenol
KW - follicle stimulating hormone
KW - follitropin
KW - fungal toxins
KW - luteinizing hormone
KW - seminal vesicle
KW - sperm
KW - sperm motility
KW - testicles
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049835&site=ehost-live&scope=site
UR - email: rsprando@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - por variable-region typing by DNA probe hybridization is broadly applicable to epidemiologic studies of Neisseria gonorrhoeae.
AU - Bash, M. C.
AU - Zhu, P. X.
AU - Gulati, S.
AU - McKnew, D.
AU - Rice, P. A.
AU - Lynn, F.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 4
SP - 1522
EP - 1530
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Bash, M. C.: Division of Bacterial, Parasitic and Allergenic Products, HFM-428, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20063064671. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - The porin gene (porB) of Neisseria gonorrhoeae encodes the major outer membrane protein identified as PI or Por. To examine the utility of por variable-region (VR) typing, porB from 206 isolates was characterized by using oligonucleotide probes in a checkerboard hybridization assay that identifies the sequence types of five VRs of both PIA and PIB porB alleles. The strains represented temporally and geographically distinct isolates, isolates from a large cluster, epidemiologically linked partner isolates, and a collection of strains from disseminated gonococcal infections. By using rigorous epidemiologic criteria for transmission of infection between sex partners, por VR typing was more discriminatory than serovar typing in classifying isolates from both members of 43 epidemiologically linked pairs: 39 of 43 pairs were classified as coinciding by por VR typing compared to 43 of 43 by serovar determination (P=0.058). porB sequence data confirmed the accuracy of the por VR method. Relationships between VR type and serovar typing monoclonal antibodies were observed for all six PIB and three of six PIA antibodies. por VR typing is a molecular tool that appears to have broad applicability. This method can be adapted to a wide range of technologies from simple hybridization to microarray and may allow for typing from noncultured clinical specimens.
KW - bacterial proteins
KW - DNA
KW - DNA probes
KW - genes
KW - genotypes
KW - gonorrhoea
KW - human diseases
KW - in situ hybridization
KW - molecular epidemiology
KW - molecular genetics
KW - nucleotide sequences
KW - surface proteins
KW - man
KW - Neisseria gonorrhoeae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - gonorrhea
KW - membrane proteins
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063064671&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/43/4/1522
UR - email: mbash@helix.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nucleic acid amplification assays for detection of La Crosse virus RNA.
AU - Lambert, A. J.
AU - Nasci, R. S.
AU - Cropp, B. C.
AU - Martin, D. A.
AU - Rose, B. C.
AU - Russell, B. J.
AU - Lanciotti, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 4
SP - 1885
EP - 1889
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Lambert, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampart Rd., Fort Collins, CO 80521, USA.
N1 - Accession Number: 20063064723. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 63231-63-0. Subject Subsets: Agroforestry; Medical & Veterinary Entomology; Public Health
N2 - We report the development of nucleic acid sequence-based amplification (NASBA) and quantitative real-time reverse transcription (RT)-PCR assays for the detection of La Crosse (LAC) virus in field-collected vector mosquito samples and human clinical samples. The sensitivities of these assays were compared to that of a standard plaque assay in Vero cells. The NASBA and quantitative real-time RT-PCR assays demonstrated sensitivities greater than that of the standard plaque assay. The specificities of these assays were determined by testing a battery of reference strain viruses, including representative strains of LAC virus and other arthropod-borne viruses. Additionally, these assays were used to detect LAC viral RNA in mosquito pool samples and human brain tissue samples and yielded results within less than 4 h. The NASBA and quantitative real-time RT-PCR assays detect LAC viral RNA in a sensitive, specific, and rapid manner; these findings support the use of these assays in surveillance and diagnostic laboratory systems.
KW - human diseases
KW - nucleotide sequences
KW - reverse transcriptase PCR
KW - RNA
KW - viral diseases
KW - Culicidae
KW - La Crosse virus
KW - man
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - DNA sequences
KW - mosquitoes
KW - reverse transcriptase polymerase chain reaction
KW - ribonucleic acid
KW - RT-PCR
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063064723&site=ehost-live&scope=site
UR - http://jcm.asm.org/cgi/content/abstract/43/4/1885
UR - email: ahk7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats.
AU - Fu, X.
AU - Latendresse, J. R.
AU - Muskhelishvili, L.
AU - Blaydes, B. S.
AU - Delclos, K. B.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 5
SP - 765
EP - 774
CY - Amsterdam; Netherlands
PB - Elsevier Ltd
SN - 0278-6915
AD - Fu, X.: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053064924. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 50-22-6. Subject Subsets: Soyabeans; Human Nutrition
N2 - In this study, dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in rats was investigated. Beginning at postnatal day (PND) 21, female Sprague-Dawley rats were fed either soy-containing NIH-31 diet or soy- and alfalfa-free 5K96 diet. On the first day of diestrus when the animals were PND 50±5, rats received either an oral dose of 80 mg/kg DMBA or sesame oil, the vehicle, and were sacrificed at 24, 36, or 48 h after treatment. Apoptosis was manifested at 24 and 36 h after DMBA treatment in the zona reticularis (ZR) and the zona fasciculata (ZF) of the adrenal cortex; this was followed by severe hemorrhagic necrosis at 48 h. DMBA-induced apoptosis, evaluated by the TUNEL assay, immunohistochemical analysis of activated caspase 3, and the ratio of expression of pro-apoptotic Bax to anti-apoptotic Bcl2, was greater in rats fed NIH-31 diet relative to rats fed 5K96 diet at 24 h after treatment. Four of six DMBA-treated rats fed 5K96 diet had severe adrenal necrosis by 48 h, whereas this lesion was present in only two of six DMBA-treated rats fed NIH-31 diet. DMBA also caused a significant decrease of serum corticosterone relative to controls at 48 h in rats fed 5K96 diet. The present study indicated that diet modulates DMBA-induced adrenal toxicity in female rats, with increased apoptosis early and reduced necrosis later in rats fed a soy-containing diet.
KW - adrenal glands
KW - animal models
KW - corticosterone
KW - laboratory animals
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adrenals
KW - anthracene
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053064924&site=ehost-live&scope=site
UR - email: xfu@nctr.fda.gov\bdelclos@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genomic analysis of vaccine-derived poliovirus strains in stool specimens by combination of full-length PCR and oligonucleotide microarray hybridization.
AU - Laassri, M.
AU - Dragunsky, E.
AU - Enterline, J.
AU - Eremeeva, T.
AU - Ivanova, O.
AU - Lottenbach, K.
AU - Belshe, R.
AU - Chumakov, K.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 6
SP - 2886
EP - 2894
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Laassri, M.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852, USA.
N1 - Accession Number: 20053128294. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Subject Subsets: Public Health
N2 - Sabin strains of poliovirus used in the manufacture of oral poliovirus vaccine (OPV) are prone to genetic variations that occur during growth in cell cultures and the organisms of vaccine recipients. Such derivative viruses often have increased neurovirulence and transmissibility, and in some cases they can reestablish chains of transmission in human populations. Monitoring for vaccine-derived polioviruses is an important part of the worldwide campaign to eradicate poliomyelitis. Analysis of vaccine-derived polioviruses requires, as a first step, their isolation in cell cultures, which takes significant time and may yield viral stocks that are not fully representative of the strains present in the original sample. Here we demonstrate that full-length viral cDNA can be PCR amplified directly from stool samples and immediately subjected to genomic analysis by oligonucleotide microarray hybridization and nucleotide sequencing. Most fecal samples from healthy children who received OPV were found to contain variants of Sabin vaccine viruses. Sequence changes in the 5′ untranslated region were common, as were changes in the VP1-coding region, including changes in a major antigenic site. Analysis of stool samples taken from cases of acute flaccid paralysis revealed the presence of mixtures of recombinant polioviruses, in addition to the emergence of new sequence variants. Avoiding the need for cell culture isolation dramatically shortened the time needed for identification and analysis of vaccine-derived polioviruses and could be useful for preliminary screening of clinical samples. The amplified full-length viral cDNA can be archived and used to recover live virus for further virological studies.
KW - children
KW - complementary DNA
KW - genomes
KW - human diseases
KW - nervous system
KW - nervous system diseases
KW - oligonucleotides
KW - paralysis
KW - poliomyelitis
KW - polymerase chain reaction
KW - strains
KW - vaccines
KW - viral diseases
KW - Maryland
KW - Missouri
KW - USA
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Corn Belt States of USA
KW - North Central States of USA
KW - West North Central States of USA
KW - cDNA
KW - human poliovirus
KW - microarrays
KW - neuropathy
KW - PCR
KW - polio
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053128294&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative analysis of immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay using virus-like particles or virus-infected mouse brain antigens to detect IgM antibody in sera from patients with evident flaviviral infections.
AU - Holmes, D. A.
AU - Purdy, D. E.
AU - Chao, D. Y.
AU - Noga, A. J.
AU - Chang, G. J. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 7
SP - 3227
EP - 3236
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Holmes, D. A.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053157566. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Tropical Diseases; Public Health; Medical & Veterinary Entomology
N2 - The use of immunoglobulin M (IgM) antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) serves as a valuable tool for the diagnosis of acute flaviviral infections, since IgM antibody titers are detectable early, peak at about 2 weeks postinfection, and subsequently decline to lower levels over the next few months. Traditionally, virus-infected tissue culture or suckling mouse brain (SMB) has been the source of viral antigens used in the assay. In an effort to provide a reliable source of standardized viral antigens for serodiagnosis of the medically important flaviviruses, we have developed a eukaryotic plasmid vector to express the premembrane/membrane and envelope proteins which self-assemble into noninfectious virus-like particles (VLPs). In addition to the plasmids for Japanese encephalitis virus, West Nile virus (WNV), St. Louis encephalitis virus (SLEV), and dengue virus type 2 (DENV-2) reported earlier, we recently constructed the DENV-1, -3, and -4 VLP expression plasmids. Three blind-coded human serum panels were assembled from patients having recent DENV, SLEV, and WNV infections to assess the sensitivity and specificity of the MAC-ELISA using VLPs or SMB antigens. In addition, serum specimens from patients infected with either Powassan virus or La Crosse encephalitis virus were used to evaluate the cross-reactivity of seven mosquito-borne viral antigens. The results of the present studies showed higher sensitivity when using SLEV and WNV VLPs and higher specificity when using SLEV, WNV, and the mixture of DENV-1 to -4 VLPs in the MAC-ELISA than when using corresponding SMB antigens. Receiver operating characteristic (ROC) curve analysis, a plot of the sensitivity versus false positive rate (100 - specificity), was applied to discriminate the accuracy of tests comparing the use of VLPs and SMB antigen. The measurement of assay performance by the ROC analysis indicated that there were statistically significant differences in assay performance between DENV and WNV VLPs and the respective SMB antigens. Additionally, VLPs had a lower cutoff positive/negative ratio than corresponding SMB antigens when employed for the confirmation of current infections. The VLPs also performed better than SMB antigens in the MAC-ELISA, as indicated by a higher positive prediction value and positive likelihood ratio test. Cell lines continuously secreting these VLPs are therefore a significantly improved source of serodiagnostic antigens compared to the traditional sources of virus-infected tissue culture or suckling mouse brain.
KW - analytical methods
KW - dengue
KW - ELISA
KW - human diseases
KW - IgM
KW - Japanese encephalitis
KW - seroprevalence
KW - St Louis encephalitis
KW - techniques
KW - viral diseases
KW - dengue 2 virus
KW - Japanese encephalitis virus
KW - La Crosse virus
KW - man
KW - Powassan virus
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - West Nile virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - California encephalitis virus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - enzyme linked immunosorbent assay
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053157566&site=ehost-live&scope=site
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors.
AU - Flynn, K. M.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Ferguson, S. A.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 9
SP - 1345
EP - 1354
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0278-6915
AD - Flynn, K. M.: Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053165941. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 72-43-5, 7440-23-5. Subject Subsets: Agricultural Entomology
N2 - Methoxychlor is an insecticide with estrogen-like activity, thus exposure during development might cause sexually dimorphic behavioral alterations. To evaluate this, pregnant rats consumed diets containing 0, 10, 100 or 1000 ppm methoxychlor from gestational day 7, and offspring continued on these diets until postnatal day (PND) 77. Assessments of sexually dimorphic behaviors in offspring indicated that intake of a 3.0% sodium chloride solution was significantly increased (41%) in males and females of the 1000 ppm group. No treatment group differed from controls in open field nor running wheel activity, play behavior, nor 0.3% saccharin solution intake. Offspring of the 1000 ppm group showed significantly decreased body weight, reaching 17% less than controls at PND 77, but not clearly related to their salt solution intake. During pregnancy, 1000 ppm dams consumed 23% less food and weighed 10% less than controls, but this did not affect litter outcomes. These results indicate that in rodents, developmental and chronic exposure to dietary methoxychlor alters the sexually dimorphic behavior of salt-solution intake in young adults of both sexes. Similar behavioral alterations with other xenoestrogens, and the potential for interactions among xenoestrogens, suggest that this report may minimize the true effects of dietary methoxychlor exposure.
KW - animal behaviour
KW - behaviour
KW - body weight
KW - insecticides
KW - methoxychlor
KW - sexual dimorphism
KW - sodium
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal behavior
KW - behavior
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053165941&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: flynn@adelphi.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mumps virus-specific antibody titers from pre-vaccine era sera: comparison of the plaque reduction neutralization assay and enzyme immunoassays.
AU - Mauldin, J.
AU - Carbone, K.
AU - Hsu, H.
AU - Yolken, R.
AU - Rubin, S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 9
SP - 4847
EP - 4851
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Mauldin, J.: Center for Biologics Evaluation and Research, FDA, Building 29A, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053193604. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Mumps virus-neutralizing antibodies are believed to be the most predictable surrogate marker of protective immunity. However, assays used to detect neutralizing antibodies, such as the plaque reduction neutralization (PRN) assay, are labor- and time-intensive and consequently are often supplanted by the more rapid and inexpensive enzyme immunoassay (EIA) technique. For virus infections for which international antibody standards exist and are bridged to clinical studies of protection (e.g., measles and rubella), the EIA has been successfully used to determine immune surrogate endpoints, yet no such international reference exists for mumps serology. Since both virus-neutralizing and nonneutralizing antibodies are measured in the EIA, in the absence of a mumps serological standard, the EIA may be prone to yielding false-positive results when utilized for assessing surrogate markers of protective immunity. Moreover, since mumps virus-specific antibody titers are generally low in comparison to antibody levels induced by other viruses and EIA procedures often employ relatively high serum dilution factors, the EIA may be prone to yielding false-negative results. To examine these issues, a PRN assay and two commercially available EIA kits were used to evaluate wild-type mumps virus serological responses in human serum samples from the pre-mumps vaccine era. Our results indicate that the PRN assay is a more sensitive and specific method of measuring serological responses to wild-type mumps virus.
KW - enzyme immunoassay
KW - human diseases
KW - immune response
KW - immunological techniques
KW - mumps
KW - neutralizing antibodies
KW - vaccination
KW - man
KW - Mumps virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - immunity reactions
KW - immunological reactions
KW - serological techniques
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053193604&site=ehost-live&scope=site
UR - email: rubins@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.
AU - Whittaker, P.
AU - San, R. H. C.
AU - Clarke, J. J.
AU - Seifried, H. E.
AU - Dunkel, V. C.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2005///
VL - 43
IS - 11
SP - 1619
EP - 1625
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0278-6915
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053170818. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 7440-47-3, 98-98-6. Subject Subsets: Human Nutrition
N2 - Chromium picolinate is one of the most commonly used chromium dietary supplements available in the United States, and it has been marketed to consumers for use in weight loss, increasing muscle mass, and lowering serum cholesterol. Chromium picolinate is a synthetic compound that provides a bioavailable form of Cr(III) that is absorbed better than dietary chromium. However, there are several reports that it can have adverse effects. In order to study the mechanism of observed cellular toxicity and mutagenicity, chromium picolinate and its component compounds, chromium (III) chloride and picolinic acid, were evaluated in Salmonella typhimurium and L5178Y mouse lymphoma cells. Neither chromium picolinate nor chromium chloride induced a mutagenic response in S. typhimurium. However, in the L5178Y mouse lymphoma mutation assay, chromium picolinate induced mutagenic responses without and with the addition of S9.
KW - adverse effects
KW - animal models
KW - chromium
KW - human diseases
KW - laboratory animals
KW - lymphoma
KW - mutagenicity
KW - mutations
KW - picolinic acid
KW - toxicity
KW - mice
KW - Salmonella typhimurium
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - adverse reactions
KW - bacterium
KW - chromium chloride
KW - chromium picolinate
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053170818&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: paul.whittaker@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of real-time PCR protocols for differential laboratory diagnosis of amebiasis.
AU - Qvarnstrom, Y.
AU - James, C.
AU - Xayavong, M.
AU - Holloway, B. P.
AU - Visvesvara, G. S.
AU - Sriram, R.
AU - Silva, A. J. da
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 11
SP - 5491
EP - 5497
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Qvarnstrom, Y.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4700 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20063001554. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health; Tropical Diseases; Protozoology
N2 - Specific identification of Entamoeba spp. in clinical specimens is an important confirmatory diagnostic step in the management of patients who may be infected with Entamoeba histolytica, the species that causes clinical amoebiasis. Distinct real-time PCR protocols have recently been published for identification of E. histolytica and differentiation from the morphologically identical nonpathogenic Entamoeba dispar. In this study, we compared three E. histolytica real-time PCR techniques published by December 2004. The limits of detection and efficiency of each real-time PCR assay were determined using DNA extracted from stool samples spiked with serially diluted cultured E. histolytica trophozoites. The ability of each assay to correctly distinguish E. histolytica from E. dispar was evaluated with DNA extracted from patients' stools and liver aspirates submitted for confirmatory diagnosis. Real-time PCR allowed quantitative analysis of the spiked stool samples, but major differences in detection limits and assay performance were observed among the evaluated tests. These results illustrate the usefulness of comparative evaluations of diagnostic assays.
KW - amoebiasis
KW - diagnostic techniques
KW - differential diagnosis
KW - DNA
KW - human diseases
KW - human faeces
KW - laboratory diagnosis
KW - liver
KW - polymerase chain reaction
KW - Entamoeba dispar
KW - Entamoeba histolytica
KW - man
KW - Entamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - amebiasis
KW - deoxyribonucleic acid
KW - human feces
KW - PCR
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063001554&site=ehost-live&scope=site
UR - email: abs8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Broth microdilution susceptibility testing of Campylobacter jejuni and the determination of quality control ranges for fourteen antimicrobial agents.
AU - McDermott, P. F.
AU - Bodeis-Jones, S. M.
AU - Fritsche, T. R.
AU - Jones, R. N.
AU - Walker, R. D.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2005///
VL - 43
IS - 12
SP - 6136
EP - 6138
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - McDermott, P. F.: U.S. Food and Drug Administration, Office of Research, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063019425. Publication Type: Journal Article. Corporate Author: USA, CampylobacterSusceptibility Testing Group Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Quality control ranges were developed for broth microdilution testing of Campylobacter jejuni ATCC 33560 against 14 antimicrobials. Cation-adjusted Mueller-Hinton broth containing 2.5% laked horse blood was the preferred medium, with incubation in a microaerobic atmosphere of 10% CO2, 5% O2, and 85% N2 at 36°C for 48 h or 42°C for 24 h.
KW - bacterial diseases
KW - culture media
KW - drug resistance
KW - drug susceptibility
KW - human diseases
KW - quality controls
KW - Campylobacter jejuni
KW - man
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - quality assurance
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063019425&site=ehost-live&scope=site
UR - email: Patrick.McDermott@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - SEN virus: epidemiology and characteristics of a transfusion-transmitted virus.
AU - Akiba, J.
AU - Umemura, T.
AU - Alter, H. J.
AU - Kojiro, M.
AU - Tabor, E.
JO - Transfusion
JF - Transfusion
Y1 - 2005///
VL - 45
IS - 7
SP - 1084
EP - 1088
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Akiba, J.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20053117395. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - SEN virus (SEN-V) is a blood-borne, single-stranded, nonenveloped DNA virus. Although its prevalence varies by geographical region, it has been detected in as many as 30% of postoperative transfusion recipients compared to 3% of postoperative patients who did not receive transfusions. A significant association has been observed between transfusion volume and SEN-V infection. Transmission by transfusion also has been confirmed by the detection of greater than 99% homology between SEN-V in donor and recipient sera. Concurrent infections with SEN-V and hepatitis B virus, hepatitis C virus or human immunodeficiency virus type 1 have been documented, and these observations probably reflect the blood-borne transmission of these viruses as well as SEN-V. Although SEN-V was discovered as part of a search for causes of posttransfusion hepatitis, there is no firm evidence so far that SEN-V infection either causes hepatitis or worsens the course of coexistent liver disease. Nevertheless, SEN-V appears to be transmitted by transfusion, and further studies may reveal more about its role in the future.
KW - blood transfusion
KW - concurrent infections
KW - disease prevalence
KW - disease transmission
KW - epidemiology
KW - hepatitis B
KW - hepatitis C
KW - HIV-1 infections
KW - human diseases
KW - liver diseases
KW - reviews
KW - viral diseases
KW - hepatitis B virus
KW - hepatitis C virus
KW - Human immunodeficiency virus 1
KW - man
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus type 1
KW - SEN virus
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053117395&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=trf
UR - email: tabor@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Co-occurrence of DSM-IV personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
AU - Grant, B. F.
AU - Stinson, F. S.
AU - Dawson, D. A.
AU - Chou, S. P.
AU - Ruan, W. J.
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
Y1 - 2005///
VL - 46
IS - 1
SP - 1
EP - 5
CY - Philadelphia; USA
PB - Elsevier Inc.
SN - 0010-440X
AD - Grant, B. F.: Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA.
N1 - Accession Number: 20053007502. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - The objective of this study was to determine the co-occurrence of 7 of the 10 Diagnosis and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) personality disorders (PDs) in the US population. Face-to-face interviews were conducted with 43 093 respondents in the National Institute on Alcohol Abuse and Alcoholism's 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative survey of the US population. Odds ratios were calculated to determine associations among PDs. All associations among PDs were positive and statistically significant. PDs were significantly associated with other PDs within the same cluster, in addition to being highly associated with PDs of other DSM-IV PD clusters. Co-occurrence between DSM-IV PDs is pervasive in the US general population. Future research is needed on the creation of dimensional representations of DSM-IV PDs as an adjunct to categorical diagnoses.
KW - abnormal behaviour
KW - behaviour
KW - epidemiology
KW - human diseases
KW - mental disorders
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - abnormal behavior
KW - behavior
KW - deviant behaviour
KW - mental illness
KW - personality disorders
KW - psychiatric disorders
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053007502&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCV-4F14S4B-5&_user=10&_handle=B-WA-A-W-AZ-MsSAYZA-UUW-AAUYYUCYWY-AAUZBYZZWY-YZDUZWDUC-AZ-U&_fmt=summary&_coverDate=01%2F01%2F2005&_rdoc=5&_orig=browse&_srch=%23toc%236748%232005%23999539998%23540782!&_cdi=6748&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6abc4d3142d4563faf3ad92047030cf7
UR - email: bgrant@willco.niaaa.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessment.
AU - Turesky, R. J.
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
Y1 - 2005///
VL - 49
IS - 2
SP - 101
EP - 117
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1613-4125
AD - Turesky, R. J.: National Center for Toxicological Research, Division of Chemistry, Jefferson, Arkansas, USA.
N1 - Accession Number: 20053048328. Publication Type: Journal Article. Language: English. Number of References: 190 ref. Registry Number: 9035-51-2, 9007-49-2, 50812-37-8. Subject Subsets: Human Nutrition; Public Health
N2 - Heterocyclic aromatic amines (HAAs) are potent bacterial mutagens that are formed in cooked meats, tobacco smoke condensate, and diesel exhaust. Many HAAs are carcinogenic in experimental animal models. Because of their wide-spread occurrence in the diet and environment, HAAs may contribute to some common types of human cancers. The extrapolation of animal toxicity data on HAAs to assess human health risk has many uncertainties, which can lead to tenuous risk assessment estimates. Perhaps the most critical and variable parameters in interspecies extrapolation are the effects of dose, species differences in catalytic activities of xenobiotic metabolism enzymes (XMEs), human XME polymorphisms that lead to interindividual differences in carcinogen metabolism, and dietary constituents that may either augment or diminish the carcinogenic potency of these genotoxins. The impact of these parameters on the metabolism and toxicological properties of HAAs and uncertainties in extrapolation of animal toxicity data for human risk assessment are presented in this article.
KW - alleles
KW - amines
KW - aromatic compounds
KW - carcinogens
KW - cytochrome P-450
KW - DNA
KW - enzyme activity
KW - enzymes
KW - food contamination
KW - foods
KW - gene expression
KW - genes
KW - genetic polymorphism
KW - genotoxicity
KW - genotypes
KW - glutathione transferase
KW - human diseases
KW - laboratory animals
KW - liver
KW - liver cells
KW - messenger RNA
KW - metabolism
KW - molecular genetics
KW - mutagens
KW - neoplasms
KW - oxidation
KW - reviews
KW - man
KW - rats
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - aromatics
KW - biochemical genetics
KW - cancers
KW - deoxyribonucleic acid
KW - food contaminants
KW - hepatocytes
KW - heterocyclic aromatic amines
KW - ligandin
KW - mRNA
KW - N-acetyltransferase
KW - sulfotransferases
KW - UDP-glucuronosyltransferase
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Physiology of Human Nutrition (VV120)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053048328&site=ehost-live&scope=site
UR - HTTP://www.wiley.com
UR - email: Rxt07@health.state.ny.us
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nicotine exposure and decontamination on tobacco harvesters' hands.
AU - Curwin, B. D.
AU - Hein, M. J.
AU - Sanderson, W. T.
AU - Nishioka, M. G.
AU - Buhler, W.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2005///
VL - 49
IS - 5
SP - 407
EP - 413
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - Curwin, B. D.: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MSR-14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053128020. Publication Type: Journal Article. Language: English. Registry Number: 54-11-5. Subject Subsets: Public Health
N2 - Green tobacco sickness is an illness associated with nicotine exposures among tobacco harvesters. Agricultural workers manually harvest tobacco and thus have the potential for skin exposure to nicotine, particularly on the hands. Often gloves are not worn as it hinders the harvesters' ability to harvest the tobacco leaves. The purposes of this study were to measure the concentration of nicotine residue on the hands of tobacco harvesters and the effectiveness of hand washing at removing the residue. Wipe samples from the hands of 12 tobacco harvesters were collected at the end of morning and afternoon work periods over two consecutive days. Each harvester had one hand wiped before washing his hands, and the other hand wiped after washing his hands with soap and water. Eight samples per worker were collected over the two days for a total of 96 samples collected. In addition to the hand-wipe samples, leaf-wipe samples were collected from 15 tobacco plants to estimate the amount of nicotine residue on the plants. The average nicotine level in leaf-wipe samples was 1.0 µg cm-2. The geometric mean pre-wash and post-wash nicotine levels on the hands were 10 and 0.38 µg cm-2, respectively. Nicotine leaf-wipe level, right or left hand and time of sampling did not significantly influence exposure. Job position - working on the bottom versus the top of the tobacco harvesting machine - was associated with nicotine levels. Pre-wash nicotine levels were higher for workers on the bottom of the harvester but not significantly higher (P=0.17). Post-wash nicotine levels were significantly higher for workers on the bottom of the harvester (P=0.012). A substantial amount of nicotine was transferred to the hands, but washing with soap and water in the field significantly reduced nicotine levels by an average of 96% (P<0.0001).
KW - decontamination
KW - farm workers
KW - hands
KW - leaves
KW - nicotine
KW - occupational hazards
KW - occupational health
KW - residues
KW - tobacco
KW - Ohio
KW - USA
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - handwashing
KW - United States of America
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053128020&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/cgi/content/abstract/49/5/407
UR - email: bcurwin@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The determination of nicotine and sulfate in supermarket ground beef adulterated with Black Leaf 40.
AU - Dasenbrock, C. O.
AU - Ciolino, L. A.
AU - Hatfield, C. L.
AU - Jackson, D. S.
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
Y1 - 2005///
VL - 50
IS - 5
SP - 1134
EP - 1140
CY - West Conshohocken; USA
PB - American Society for Testing and Materials (ASTM)
SN - 0022-1198
AD - Dasenbrock, C. O.: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20053192652. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 54-11-5. Subject Subsets: Human Nutrition
N2 - In December 2002, approximately 250 lbs of ground beef was adulterated with nicotine sulfate by a supermarket employee and subsequently sold to the public in USA. Soon afterward, reports of illness associated with ground beef purchased at a single store were identified. Authorities suspected the ground beef was tainted with Black Leaf 40, a banned pesticide containing approximately 40% nicotine as nicotine sulfate. Ground beef submitted to our laboratory was analysed in concert by high performance liquid chromatography-ultraviolet detection (HPLC-UV), gas chromatography-mass spectrometry (GC-MS), and high performance anion exchange chromatography with suppressed conductivity detection. GC-MS was used to identify the samples that contained nicotine. The nicotine was confirmed and quantitated by HPLC-UV. The sulfate was identified and quantitated by high performance anion exchange chromatography with suppressed conductivity detection. Our analysis revealed that the raw tainted beef contained about 350 mg/kg nicotine free base, a potentially lethal dose of nicotine per serving for an adult. Additionally, we found elevated sulfate levels in the samples that tested positive for nicotine, providing evidence that nicotine sulfate was the probable adulterant.
KW - beef
KW - determination
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - ground beef
KW - nicotine
KW - pesticide residues
KW - toxicology
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053192652&site=ehost-live&scope=site
UR - http://www.aafs.org/?section_id=journal_of_fs&page_id=contact_info
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health importance of Brachiola algerae (Microsporidia) - an emerging pathogen of humans.
AU - Visvesvara, G. S.
AU - Moura, H.
AU - Leitch, G. J.
AU - Schwartz, D. A.
AU - Xiao, L. X.
A2 - Lom, J.
A2 - Vávra, J.
A2 - Weiss, L. M.
A2 - Bukva, V.
JO - Folia Parasitologica
JF - Folia Parasitologica
Y1 - 2005///
VL - 52
IS - 1/2
SP - 83
EP - 94
CY - České Budejovice; Czech Republic
PB - Institute of Parasitology, Academy of Sciences of the Czech Republic
SN - 0015-5683
AD - Visvesvara, G. S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20053112547. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 38 ref. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Biocontrol; Public Health
N2 - Brachiola algerae, a parasite of Anopheles mosquitoes, has been isolated from a human cornea, a cutaneous nodule and deep muscle tissue. All three human isolates of B. algerae are morphologically, serologically, and genetically similar to the mosquito-derived isolates. All of these isolates grew well in mammalian cell cultures at 37°C and produced spores. Transmission electron microscopy revealed that all developmental stages including meronts, sporoblasts and spores were diplokaryotic and developed in direct contact with the host cell cytoplasm, a feature characteristic of the genus Brachiola. Spores of all isolates reacted well, in the immunofluorescence assay, with the rabbit anti-B. algerae serum. In the immunoblot assay, although the overall banding patterns of the human and mosquito isolates were similar, minor differences could be discerned. Sequencing of the PCR products of the amplified SSU rRNA gene revealed the existence of two distinct genotypes; the original mosquito isolate belonged to genotype 1 and the isolate from cornea and that from the deep muscle biopsy to genotype 2, whereas the isolates from a mosquito and one of the other two human isolates (one from skin abscess) had both genotypes, 1 and 2. It is known that spores of mosquito-derived B. algerae not only can proliferate in mammalian cell cultures at 37°C, but also can infect mice when injected into footpads or deposited on the corneal surface. These observations indicate that the spores have potential to be a risk factor for humans, especially those with immunodeficiency.
KW - cornea
KW - developmental stages
KW - emerging infectious diseases
KW - entomopathogenic protozoa
KW - entomopathogens
KW - genes
KW - genotypes
KW - human diseases
KW - microsporidiosis
KW - molecular genetics
KW - muscles
KW - natural enemies
KW - pathogens
KW - ribosomal RNA
KW - skin
KW - spores
KW - Anopheles
KW - Culicidae
KW - man
KW - Microspora
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoa
KW - Nosematidae
KW - Microspora
KW - biochemical genetics
KW - Brachiola
KW - Brachiola algerae
KW - dermis
KW - emerging diseases
KW - emerging infections
KW - eye cornea
KW - growth phase
KW - mosquitoes
KW - rRNA
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053112547&site=ehost-live&scope=site
UR - http://www.cabi.org/cabdirect/showpdf.aspx?PAN=http://www.cabi.org/cabdirect/showpdf.aspx?PAN=20053112547
UR - email: gsv1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS.
AU - Turesky, R. J.
AU - Taylor, J.
AU - Schnackenberg, L.
AU - Freeman, J. P.
AU - Holland, R. D.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2005///
VL - 53
IS - 8
SP - 3248
EP - 3258
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Turesky, R. J.: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053098632. Publication Type: Journal Article. Language: English. Subject Subsets: Poultry
N2 - A tandem solid-phase extraction method was used to isolate carcinogenic heterocyclic aromatic amines (HAAs) from cooked meats. The following 10 HAAs were identified by HPLC/ESI-MS/MS: 2-amino-9H-pyrido[2,3-b]indole (2-AαC), 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), 2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline (7,8-DiMeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (7,9-DiMeIgQx), and 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]); the latter HAA has not previously been reported in cooked meats. The concentrations of these HAAs ranged from <0.03 to 15 ppb in cooked meats and poultry, to 75 ppb in cooked beef extract, and to 85 ppb in grill scrapings. The product ion scan mode was used to confirm the identities of these HAAs. Six other compounds were detected that appear to contain the N-methylimidazoquinoxaline skeleton on the basis of their product ion spectra, and these compounds are probable isomers of IQx, 8-MeIQx, and DiMeIQx. A number of known HAAs and novel HAAs of unknown genotoxic potential are formed at appreciable levels in cooked meats.
KW - amines
KW - analytical methods
KW - aromatic compounds
KW - beef
KW - carcinogens
KW - chemical composition
KW - chicken meat
KW - cooking
KW - food consumption
KW - food processing
KW - HPLC
KW - mass spectrometry
KW - meat
KW - poultry
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - aromatics
KW - chickens
KW - domesticated birds
KW - heterocyclic aromatic amines
KW - high performance liquid chromatography
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053098632&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2005/53/i08/abs/jf048290g.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of fatty acid profiles to identify food-borne bacterial pathogens and aerobic endospore-forming bacilli.
AU - Whittaker, P.
AU - Fry, F. S.
AU - Curtis, S. K.
AU - Al-Khaldi, S. F.
AU - Mossoba, M. M.
AU - Yurawecz, M. P.
AU - Dunkel, V. C.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2005///
VL - 53
IS - 9
SP - 3735
EP - 3742
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053098895. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Human Nutrition
N2 - Capillary gas chromatography (GC) with flame ionization detection was used to determine the cellular fatty acid profiles of various food-borne microbial pathogens and to compare the fatty acid profiles of spores and vegetative cells of the same endospore-forming bacilli. Fifteen bacteria, representing eight genera (Staphylococcus, Listeria, Bacillus, Yersinia, Salmonella, Shigella, Escherichia, and Vibrio) and 11 species were used to compare the extracted fatty acid methyl esters (FAMEs). Endospore-forming bacilli were processed to obtain pure spores and whole cell FAMEs for GC analysis. A data set for each bacterial agent was prepared using fatty acid profiles from five replicates prepared on different days. The results showed that these fatty acid intensity profiles were unique for each of the 11 species and that they could be used as a fingerprint for the organisms. The cellular fatty acid profiles for Bacillus anthracis and Bacillus cereus show that there are two branched chain fatty acids, iso 17:1 ω10c and 17:1 anteiso, which are unique in these species. Iso 17:1 ω10c is present in B. cereus vegetative cells and spores but is not observed in B. anthracis. The 17:1 anteiso fatty acid is present in B. anthracis cells but not in B. cereus cells. Fatty acids 16:0 2OH and 17:0 iso 3OH are present in B. anthracis and B. cereus spores but not in the vegetative cells. In summary, analysis of FAMEs from bacteria and spores can provide a sensitive procedure for the identification of food-borne pathogens.
KW - bacterial spores
KW - fatty acids
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - methodology
KW - microbial contamination
KW - Bacillus anthracis
KW - Bacillus cereus
KW - Escherichia
KW - Listeria
KW - Salmonella
KW - Shigella
KW - Staphylococcus
KW - Vibrio
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Listeriaceae
KW - Staphylococcaceae
KW - Vibrionaceae
KW - Vibrionales
KW - Bacillus
KW - bacterium
KW - food contaminants
KW - methods
KW - Yersinia
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053098895&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2005/53/i09/abs/jf040458a.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The determination of semicarbazide (N-aminourea) in commercial bread products by liquid chromatography-mass spectrometry.
AU - Noonan, G. O.
AU - Warner, C. R.
AU - Hsu, W. C.
AU - Begley, T. H.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2005///
VL - 53
IS - 12
SP - 4680
EP - 4685
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Noonan, G. O.: Office of Food Additive Safety, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20053118348. Publication Type: Journal Article. Language: English. Registry Number: 100-52-7. Subject Subsets: Human Nutrition
N2 - Recently, semicarbazide has been found in food in jars sealed with cap liners that were manufactured using azodicarbonamide as a blowing agent. These reports raised the concern that the use of azodicarbonamide-an approved dough conditioner-may result in semicarbazide residues in bread. To answer this question, a method based upon the previously reported liquid chromatography/tandem mass spectrometry determination of the semicarbazone of o-nitrobenzaldehyde was utilized. The method adopted for this work includes an extensive cleanup and reaction with o-nitrobenzaldehyde at pH 3.5, rather than with the widely used 0.1 M HCl, to form the semicarbazone derivative. A stable isotope dilution assay was used to determine the free semicarbazide present in the bread products. Levels of semicarbazide ranged from 10 to 1200 ppb in commercial bread products with azodicarbonamide listed among their ingredients.
KW - benzaldehyde
KW - bread
KW - food contamination
KW - HPLC
KW - residues
KW - aminourea
KW - azocarbonamide
KW - food contaminants
KW - high performance liquid chromatography
KW - semicarbazide
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053118348&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2005/53/i12/abs/jf050480j.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatography-tandem mass spectrometry for the determination of protein-bound residues in shrimp dosed with nitrofurans.
AU - Chu, P. S.
AU - Lopez, M. I.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2005///
VL - 53
IS - 23
SP - 8934
EP - 8939
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Chu, P. S.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063064888. Publication Type: Journal Article. Language: English. Registry Number: 139-91-1, 67-45-8, 59-87-0, 67-20-9. Subject Subsets: Human Nutrition
N2 - An analytical method was developed for the determination of bound residues of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin with a sensitivity of 1 ppb in shrimp. In this procedure, shrimp tissue is prewashed with solvents followed by overnight acid hydrolysis, during which the side chains of the bound residues are released and simultaneously derivatized with 2-nitrobenzaldehyde. After liquid-liquid extraction cleanup, the derivatives are detected and quantitated using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) with an atmospheric pressure chemical ionization interface. The method was validated using control shrimp fortified with each side-chain analyte at 1, 2, and 4 ppb. Method accuracies were >80% with coefficients of variation of <20% for all four analytes. Tissues from dosed shrimp were assayed to demonstrate the effectiveness of the method for recovering bound residues of nitrofurans. In shrimp dosed with nitrofurans, nitrofurantoin exhibited the lowest level of bound residues.
KW - analytical methods
KW - antiinfective agents
KW - drug residues
KW - food contamination
KW - furaltadone
KW - furazolidone
KW - liquid chromatography
KW - mass spectrometry
KW - nitrofural
KW - nitrofurans
KW - nitrofurantoin
KW - seafoods
KW - shellfish
KW - shrimps
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - analytical techniques
KW - antimicrobials
KW - food contaminants
KW - nitrofurazone
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063064888&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2005/53/i23/abs/jf051615o.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silicosis mortality, prevention, and control - United States, 1968-2002.
AU - Bang, K. M.
AU - Mazurek, J. M.
AU - Attfield, M. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2005///
VL - 54
IS - 16
SP - 401
EP - 405
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Bang, K. M.: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20053087351. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - To describe patterns of silicosis mortality in the USA, the Centers for Disease Control analysed data from the National Institute for Occupational Safety and Health National Occupational Respiratory Mortality System for 1968-2002. This report summarizes the results of that analysis, which indicated a decline in silicosis mortality during 1968-2002 and suggested that progress has been made in reducing the incidence of silicosis in the USA.
KW - disease prevalence
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupational health
KW - silicosis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatal injuries among volunteer workers - United States, 1993-2002.
AU - Struttmann, T. W.
AU - Oerter, B. T.
AU - Noe, R. S.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2005///
VL - 54
IS - 30
SP - 744
EP - 747
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Struttmann, T. W.: Div of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20053141626. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - The results indicated that a total of 501 persons died from injuries sustained while volunteering during this period; most often these persons were firefighters and other volunteers who were operating motor vehicles at the time of death. The overall rate of death among volunteers was 3.2 per 100 000 full-time equivalent population. The fatal injury rates for volunteers workers aged ≥35 years were lower when compared with the overall volunteer death rate. To reduce these fatalities, organizations that rely on volunteers need to provide adequate training (e.g., defensive driving and recognition of evacuation signals) on the basis of well-communicated and enforced safety and health policies.
KW - age
KW - epidemiology
KW - fire fighters
KW - mortality
KW - trauma
KW - voluntary services
KW - volunteers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - firemen
KW - traumas
KW - United States of America
KW - voluntary agencies
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053141626&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animals.
AU - Singh, R.
AU - Schroeder, C. M.
AU - Meng, J. H.
AU - White, D. G.
AU - McDermott, P. F.
AU - Wagner, D. D.
AU - Yang, H. C.
AU - Simjee, S.
AU - DebRoy, C.
AU - Walker, R. D.
AU - Zhao, S. H.
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2005///
VL - 56
IS - 1
SP - 216
EP - 219
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Singh, R.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053140831. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 58-71-9, 153-61-7, 33564-30-6, 35607-66-0, 56-75-7, 1403-66-3, 1405-41-0, 57-92-1, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Public Health; Poultry; Pig Science; Veterinary Science; Veterinary Science
N2 - Objectives: The objective of this study was to identify antimicrobial resistance and class 1 integrons among Shiga toxin-producing Escherichia coli (STEC). Methods: Two-hundred and seventy-four STEC recovered from poultry, cattle, swine and humans were characterized by antimicrobial susceptibility testing, screened for the presence of class 1 integrons by PCR, and assayed for integron transfer by conjugation. Results: Ninety-three (34%) of the isolates were resistant to streptomycin, followed by 89 (32%) to sulfamethoxazole, 83 (30%) to tetracycline, 48 (18%) to ampicillin, 29 (11%) to cefalothin, 22 (8%) to trimethoprim/sulfamethoxazole, 18 (7%) to gentamicin, 13 (5%) to chloramphenicol and 10 (4%) to cefoxitin. Class 1 integrons were detected in 43 (16%) of the 274 isolates. The adenyl acetyltransferase gene, aadA, which confers resistance to streptomycin, was identified in integrons from 41 (95%) of these 43 isolates, and the dfrA12 gene, which confers resistance to trimethoprim, was identified in integrons from eight (19%) of the isolates. The sat1 gene, which confers resistance to streptothricin, an antimicrobial that has never been approved for use in the United States, was identified in integrons from three (7%) of the isolates. Transfer of integrons by conjugation between strains of E. coli resulted in transfer of antimicrobial-resistant phenotypes for ampicillin, chloramphenicol, cefalothin, gentamicin, tetracycline, trimethoprim, sulfamethoxazole and streptomycin. Conclusions: Antimicrobial resistance is common in STEC. Class 1 integrons located on mobile plasmids have facilitated the emergence and dissemination of antimicrobial resistance among STEC in humans and food animals.
KW - ampicillin
KW - antibacterial agents
KW - bacterial diseases
KW - bacterial toxins
KW - cefalotin
KW - cefoxitin
KW - chloramphenicol
KW - drug resistance
KW - drug susceptibility
KW - gentamicin
KW - human diseases
KW - phenotypes
KW - poultry
KW - streptomycin
KW - sulfamethoxazole
KW - tetracycline
KW - trimethoprim
KW - cattle
KW - Escherichia coli
KW - man
KW - pigs
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - achromycin
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cephalothin
KW - domesticated birds
KW - E. coli
KW - hogs
KW - integrons
KW - streptothricin
KW - sulphamethoxazole
KW - swine
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053140831&site=ehost-live&scope=site
UR - http://jac.oxfordjournals.org/
UR - email: szhao@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An analysis of administrative data found that proximate clinical event ratios provided a systematic approach to identifying possible iatrogenic risk factors or complications.
AU - Baine, W. B.
AU - Kazakova, S. V.
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2005///
VL - 58
IS - 2
SP - 162
EP - 170
CY - New York; USA
PB - Elsevier
SN - 0895-4356
AD - Baine, W. B.: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850-6649, USA.
N1 - Accession Number: 20053050792. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Subject Subsets: Public Health
N2 - Objective: A method to generate hypotheses about iatrogenic risk factors and complications from administrative data was developed and tested using hospitalization of the elderly for depression as a model. Study Design and Setting: Hospital claims were selected for 30 998 elderly inpatients admitted for the first time for depression. Common principal diagnoses and procedures in hospitalizations within 90 days of the index depression admission were tallied. For each of these proximate clinical events, the ratio of how many happened before the index admission to how many occurred afterward was calculated. Ratios diverging markedly from unity were identified to generate hypotheses about possible risk factors associated with depression and complications associated with its management. Results: Hospitalization for degenerative joint disease or back problems; abdominal pain or gastritis and duodenitis; coronary artery disease; or cerebrovascular disease was more common before an index depression admission than after it, as were coronary artery surgery, total knee replacement, and cholecystectomy. Admissions for fracture of the femoral neck - an established iatrogenic complication - were disproportionately likely after the index admission. So were admissions for aspiration pneumonia or acute respiratory failure. Conclusion: Proximate clinical event ratios provide a systematic approach to screening administrative data to identify candidates for further evaluation as possible iatrogenic risk factors or complications.
KW - bone fractures
KW - cerebrovascular disorders
KW - clinical aspects
KW - complications
KW - depression
KW - disease models
KW - elderly
KW - epidemiology
KW - human diseases
KW - methodology
KW - ratios
KW - risk factors
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aged
KW - clinical picture
KW - elderly people
KW - methods
KW - older adults
KW - screening tests
KW - senior citizens
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053050792&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08954356
UR - email: wbaine@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The use of focus groups to elicit a consumer perspective on healthy eating, dietary fat and wholegrains.
AU - Sladden, K.
JO - Journal of the New Zealand Dietetic Association
JF - Journal of the New Zealand Dietetic Association
Y1 - 2005///
VL - 59
IS - 1
SP - 5
EP - 9
CY - Wellington; New Zealand
PB - New Zealand Dietetic Association Inc.
SN - 0110-635X
AD - Sladden, K.: Auckland Regional Public Health Service, Auckland, New Zealand.
N1 - Accession Number: 20063075069. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - Aim: To elucidate overweight adult consumer perceptions of healthy eating and identify motivators and barriers to dietary change (focusing on reducing fat and increasing wholegrain consumption) through a series of focus groups. Methods: Twelve focus groups were undertaken with adults aged 25-39 years. Data from the focus groups were analysed using a general inductive approach to identify common, dominant or significant themes. Results: Participants consistently defined healthy eating in terms of foods to avoid, creating an overriding perception of restriction. Key barriers to dietary change identified as taste, convenience, cost and accessibility were in most cases inextricably linked. Length of life was identified as an important motivating factor but gender differences were apparent with men expressing a desire to retain their independence as they aged. Men also professed to be motivated by uncompromising factual accounts of the deleterious effects of poor diets whereas women preferred a more supportive approach. No consistent differences were found between different ethnic groups. Conclusions and implications: As taste was the definitive determinant of food choice, the importance of evaluating nutrition messages in terms of palatability cannot be underestimated. It is appropriate to consider the development of separate nutrition messages for males and females.
KW - attitudes
KW - behaviour
KW - consumers
KW - diets
KW - feeding behaviour
KW - feeding habits
KW - food preferences
KW - human diseases
KW - overweight
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - diet preferences
KW - eating habits
KW - feeding behavior
KW - taste preferences
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063075069&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of telephone and postal surveys to evaluate a consumer food safety campaign.
AU - Imlach, F.
AU - Simmons, G.
JO - Journal of the New Zealand Dietetic Association
JF - Journal of the New Zealand Dietetic Association
Y1 - 2005///
VL - 59
IS - 2
SP - 36
EP - 41
CY - Wellington; New Zealand
PB - New Zealand Dietetic Association Inc.
SN - 0110-635X
AD - Imlach, F.: Auckland Regional Public Health Service, Auckland, New Zealand.
N1 - Accession Number: 20053204578. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Human Nutrition
N2 - Since 1999, the New Zealand Foodsafe Partnership has conducted an annual campaign to promote domestic food safety. The 2004/2005 campaign was evaluated with concurrent national postal and telephone surveys. A single mail-out questionnaire was posted to 1500 people randomly selected from the general electoral roll (response rate 28%); the telephone survey used random digit dial numbers (response rate 43%). The age, gender and ethnicity of respondents were similar in both samples but each had more female and fewer Maori and Pacific respondents than the total New Zealand population. At least one campaign activity was recalled by 55% (95% CI: 50-59%) of respondents in the telephone survey and 49% (95% CI: 44-54%) in the postal survey. Of these, 19% (95% CI: 14-24%) and 27% (95% CI: 21-34%) respectively reported a change in their home food handling behaviour and close to half could name one or more of the 4Cs (Clean, Cook, Cover, Chill). The telephone survey cost $7.33 per completed response, which was only marginally more expensive than the postal survey at $7.04. Both surveys gave similar evaluation results but the telephone survey had the advantages of a higher response rate, being quicker to perform and providing more complete data than the postal survey.
KW - consumers
KW - food safety
KW - methodology
KW - surveys
KW - New Zealand
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053204578&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Promoting public health and protecting consumers in a global economy: an overview of HHS/FDA's international activities.
AU - Kelly, D. P.
AU - Bachorik, L. L.
T2 - Food and Drug Law Journal
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 2005///
VL - 60
IS - 3
SP - 339
EP - 346
CY - Washington; USA
PB - Food and Drug Law Institute
SN - 1064-590X
AD - Kelly, D. P.: International Policy, Department of Health and Human Services (HHS), Food and Drug Administration (FDA), Rockville, Maryland, USA.
N1 - Accession Number: 20053203930. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Public Health
N2 - Globalization has brought both increased risks to human health and greater opportunities to promote public health and to protect consumers. Government agencies that historically are primarily domestic in nature, such as the Department of Health and Human Services (HHS), are addressing global issues such as increased international trade in foods, pharmaceuticals and medical products, bioterrorism and emerging infectious diseases with potential global impact. Within HHS, the US Food and Drug Administration's (FDA's) Office of International Programs (OIP) leads, manages and coordinates HHS/FDA's international activities. HHS/FDA conducts this work through a mixture of interactions within multinational organizations and multilateral and bilateral arrangements with specific foreign counterpart agencies, efforts that are all supported by appropriate US government interagency and interdepartmental cooperation. OIP works in close collaboration with each of HHS/FDA's programmatic centres and the Office of Regulatory Affairs to conduct international activities. Experts from all over the agency, as appropriate, are engaged in the agency's international work.
KW - biological warfare
KW - bioterrorism
KW - consumer protection
KW - drugs
KW - emerging infectious diseases
KW - foods
KW - globalization
KW - health promotion
KW - human diseases
KW - international cooperation
KW - international trade
KW - public agencies
KW - public health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - emerging diseases
KW - emerging infections
KW - government agencies
KW - internationalization
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Food Economics (EE116) (New March 2000)
KW - Health Economics (EE118) (New March 2000)
KW - International Trade (EE600)
KW - Consumer Economics (EE720)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053203930&site=ehost-live&scope=site
UR - http://www.fdli.org/pubs/Journal%20Online/jour_toc/vol60_3.html#1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid, specific detection of Enterobacter sakazakii in infant formula using a real-time PCR assay.
AU - Seo, K. H.
AU - Brackett, R. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 1
SP - 59
EP - 63
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Seo, K. H.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy, Foods, and Beverages, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053019853. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - Enterobacter sakazakii is a rare cause of invasive infection with high mortality rates in neonates. Powdered milk-based infant formulae have been associated with the E. sakazakii-related outbreaks in premature or other immunocompromised infants. In this study, an assay was developed for the specific detection of E. sakazakii in infant formula using an application of the fluorogenic 5′ nuclease assay (TaqMan). A set of primers and probe was designed using the E. sakazakii partial macromolecular synthesis operon: the rpsU gene 3′ end and the primase (dnaG) gene 5′ end. The specificity of the assay was evaluated using 68 Enterobacter and 55 non-Enterobacter strains. The newly developed assay enables us to detect 100 CFU/ml in pure culture and in reconstituted infant formula in 50 cycles of PCR without enrichment. The assay was specific enough to discriminate E. sakazakii from all other Enterobacter and non-Enterobacter strains tested. The developed real-time PCR assay could save up to 5 days and eliminate the need for plating samples on selective or diagnostic agars and for biochemical confirmation steps. The real-time PCR assay could be used to rapidly screen infant formula samples for E. sakazakii and would be a boon to food industries and regulatory agencies.
KW - detection
KW - dried milk
KW - food contamination
KW - infant formulae
KW - methodology
KW - microbial contamination
KW - milk
KW - polymerase chain reaction
KW - Enterobacter sakazakii
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - methods
KW - milk powder
KW - PCR
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053019853&site=ehost-live&scope=site
UR - email: kseo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of prior growth conditions on the thermal inactivation of 13 strains of Listeria monocytogenes in two heating menstrua.
AU - Edelson-Mammel, S. G.
AU - Whiting, R. C.
AU - Joseph, S. W.
AU - Buchanan, R. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 1
SP - 168
EP - 172
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Edelson-Mammel, S. G.: Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20053019842. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Soyabeans
N2 - The thermal tolerance of 13 Listeria monocytogenes strains was tested using a submerged heating coil apparatus. The strains were grown individually for 18 h at 37°C in acidogenic tryptic soy broth (without dextrose) supplemented with 1% glucose and 1% glutamine (TSB+G) or nonacidogenic tryptic soy broth supplemented with 1% glutamine but containing no glucose (dextrose) (TSB-G). The former medium results in cells induced for pH-dependent, stationary-phase acid resistance, whereas the latter medium allows L. monocytogenes to grow to high numbers in the absence of glucose, yielding cells that are not induced for pH-dependent, stationary-phase acid resistance. The average final pH values of the 18-h TSB+G and the TSB-G cultures were 4.7 and 6.7, respectively. The cells grown in the acid resistance-inducing and non-acid resistance-inducing media were then tested in two heating menstrua that consisted of brain heart infusion broth adjusted to pH 3.0 and water activity (aw) of 0.987 or pH 7.0 and aw 0.970. In 14 of the 26 menstruum-strain combinations tested, the acid resistance-induced strains were more heat resistant then the equivalent noninduced cultures. No difference in the pattern of thermal resistance in response to induction of acid resistance was apparent among the different serovars tested. The results suggest that the ability of prior induction of acid resistance to enhance thermal resistance can vary substantially among L. monocytogenes strains.
KW - food contamination
KW - food processing
KW - growth
KW - heat resistance
KW - heat treatment
KW - microbial contamination
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - heat processing
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053019842&site=ehost-live&scope=site
UR - email: Robert.Buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Asimitrin and 4-hydroxytrilobin, new bioactive annonaceous acetogenins from the seeds of Asimina triloba possessing a bis-tetrahydrofuran ring.
AU - Kim EunJung
AU - Suh KyungMi
AU - Kim DalHwan
AU - Jung EunJoo
AU - Seo ChangSeob
AU - Son JongKeun
AU - Woo MiHee
AU - McLaughlin, J. L.
JO - Journal of Natural Products
JF - Journal of Natural Products
Y1 - 2005///
VL - 68
IS - 2
SP - 194
EP - 197
CY - Washington; USA
PB - American Chemical Society
SN - 0163-3864
AD - Kim EunJung: Narcotic & Neuropharmacological Drug Division, Drug Evaluation Department, Korea Food and Drug Administration, Seoul, 122-020, Korea Republic.
N1 - Accession Number: 20053051170. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Seed Science; Forestry; Aromatic & Medicinal Plants; Forest Products
N2 - Bioactivity-directed fractionation of the seeds of Asimina triloba resulted in the isolation of asimitrin (1) and 4-hydroxytrilobin (2). Compound 1 represents an adjacent ring-hydroxylated bis-tetrahydrofuran (THF) acetogenin. Compound 2 has an adjacent bis-THF ring with two flanking hydroxyl groups and a α,β-unsaturated γ-lactone with a 4-hydroxyl group. Compounds 1 and 2 showed cytotoxic selectivity, with 100-10 000 times the potency of adriamycin against prostate adenocarcinoma (PC-3) and colon adenocarcinoma (HT-29) cell lines.
KW - acetogenins
KW - adenocarcinoma
KW - cell lines
KW - chemical composition
KW - colon
KW - cytotoxicity
KW - medicinal plants
KW - non-wood forest products
KW - plant composition
KW - prostate
KW - seeds
KW - Maryland
KW - Washington
KW - Asimina triloba
KW - Asimina
KW - Annonaceae
KW - Magnoliales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - Pacific States of USA
KW - Western States of USA
KW - chemical constituents of plants
KW - drug plants
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - polyketides
KW - Plant Composition (FF040)
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Non-wood Forest Products (KK540)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053051170&site=ehost-live&scope=site
UR - email: woomh@cu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of green fluorescent protein-expressing bacterial strains and evaluation for potential use as positive controls in sample analyses.
AU - Noah, C. W.
AU - Shaw, C. I.
AU - Ikeda, J. S.
AU - Kreuzer, K. S.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 4
SP - 680
EP - 686
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Noah, C. W.: Denver District Office, Food and Drug Administration, 6th Avenue and Kipling Street, Denver, CO 80225, USA.
N1 - Accession Number: 20053080096. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Dairy Science; Public Health; Human Nutrition; Soyabeans
N2 - Strains of enterohaemorrhagic Escherichia coli O157:H7 and Salmonella typhimurium were engineered to express the gene for a modified green fluorescent protein (GFP) and were evaluated for potential use as positive controls in sample analyses. The strains fluoresced when observed as colonies with a handheld UV lamp or as individual cells under a fluorescent microscope. The strains maintained their fluorescence following growth in three series of transfer experiments including 8 to 11 passages from broth to broth and twice for 15 consecutive transfers from broth onto Trypticase soy agar plates. Cultures also maintained stability in the ability to fluoresce when agar plates were refrigerated (4°C) for up to 12 days. Growth characteristics of the GFP-positive strains were comparable to those of corresponding control strains. The GFP-positive strains were successfully identified using rapid diagnostic methods and were differentiated from their corresponding non-GFP strains by pulsed-field gel electrophoresis but not by repetitive extragenic palindromic PCR. The GFP-positive and the control strains were recovered successfully from individually inoculated food samples (Feta cheese, raw shrimp, cooked shrimp, and cooked crawfish). However, in one Feta cheese sample and one raw shrimp sample inoculated with combined GFP-positive and GFPnegative cultures, colonies of the GFP-positive strains were not observed under UV light; fluorescing cells in one of the inoculated samples (raw shrimp) were revealed by microscopy. In general, the isolates from the inoculated foods were GFP positive by microscopic examination; the pure isolates could also be restreaked onto Trypticase soya agar, and colonies could be visually examined under UV light. Because GFP strains are not known to occur naturally in the environment, the use of the Salmonella GFP-positive strain may offer advantages as a positive control even when distinct and rare serotypes are available. The GFP-positive E. coli O157:H7 strain may also prove beneficial for use as a positive control strain for sample analyses.
KW - cheeses
KW - crayfish
KW - Feta cheese
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - shrimps
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Salmonella typhimurium
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Escherichia coli
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Milk and Dairy Produce (QQ010)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053080096&site=ehost-live&scope=site
UR - email: cnoah@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Science and Technology Based Countermeasures to Foodborne Terrorism: introduction.
AU - Miller, A. J.
AU - Hileman, C. L.
AU - Droby, S.
AU - Paster, N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 6
SP - 1253
EP - 1255
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Miller, A. J.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, U.S. Department of Health and Human Services, College Park, MD 21074, USA.
N1 - Accession Number: 20053116910. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - The need for improved technologies that will minimize the likelihood and reduce the scope of a terrorist attack against the food supply is discussed, including the need for increased international cooperation from governments, companies and educational institutions around the world, specifically in conducting research on the development of methods and technologies for hazard mitigation, threat identification and medical treatment.
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - methodology
KW - microbial contamination
KW - terrorism
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Conflict (UU495) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053116910&site=ehost-live&scope=site
UR - email: amiller@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methods for detection of Clostridium botulinum toxin in foods.
AU - Sharma, S. K.
AU - Whiting, R. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 6
SP - 1256
EP - 1263
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Sharma, S. K.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053116911. Publication Type: Journal Article. Language: English. Number of References: 94 ref. Subject Subsets: Human Nutrition
N2 - Botulism is a deadly disease caused by ingestion of the preformed neurotoxin produced from the anaerobic spore-forming bacteria Clostridium botulinum. Botulinum neurotoxins are the most poisonous toxins known and have been a concern in the food industry for a long time. Therefore, rapid identification of botulinum neurotoxin using molecular and biochemical techniques is an essential component in the establishment of coordinated laboratory response systems and is the focus of current research and development. Because of the extreme toxicity of botulinum neurotoxin, some confirmatory testing with the mouse bioassay is still necessary, but rapid methods capable of screening large numbers of samples are also needed. This review is focused on the development of several detection methods for botulinum neurotoxins in foods.
KW - analytical methods
KW - bacterial toxins
KW - food contamination
KW - microbial contamination
KW - neurotoxins
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053116911&site=ehost-live&scope=site
UR - email: shashi.sharma@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Staphylococcal enterotoxin and its rapid identification in foods by enzyme-linked immunosorbent assay-based methodology.
AU - Bennett, R. W.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 6
SP - 1264
EP - 1270
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Bennett, R. W.: U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053116912. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition; Public Health
N2 - The problem of Staphylococcus aureus and other species as contaminants in the food supply remains significant on a global level. Time and temperature abuse of a food product contaminated with enterotoxigenic staphylococci can result in formation of enterotoxin, which can produce foodborne illness when the product is ingested. Between 100 and 200 ng of enterotoxin can cause symptoms consistent with staphylococcal intoxication. Although humans are the primary reservoirs of contamination, animals, air, dust, and food contact surfaces can serve as vehicles in the transfer of this pathogen to the food supply. Foods may become contaminated during production or processing and in homes or food establishments, where the organism can proliferate to high concentrations and subsequently produce enterotoxin. The staphylococcal enterotoxins are highly heat stable and can remain biologically active after exposure to retort temperatures. Prior to the development of serological methods for the identification of enterotoxin, monkeys (gastric intubation) and later kittens (intravenous injection) were used in assays for toxin detection. When enterotoxins were identified as mature proteins that were antigenic, serological assays were developed for use in the laboratory analysis of foods suspected of containing preformed enterotoxin. More recently developed methods are tracer-labeled immunoassays. Of these methods, the enzyme-linked immunosorbent assays are highly specific, highly sensitive, and rapid for the detection of enterotoxin in foods.
KW - bacterial toxins
KW - ELISA
KW - enterotoxins
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - methodology
KW - microbial contamination
KW - Staphylococcus aureus
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053116912&site=ehost-live&scope=site
UR - email: reginald.bennett@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chips and SNPs, bugs and thugs: a molecular sleuthing perspective.
AU - Cebula, T. A.
AU - Jackson, S. A.
AU - Brown, E. W.
AU - Goswami, B.
AU - LeClerc, J. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 6
SP - 1271
EP - 1284
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cebula, T. A.: Division of Molecular Biology (HFS-025), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20053116913. Publication Type: Journal Article. Language: English. Number of References: 102 ref. Subject Subsets: Medical & Veterinary Entomology; Human Nutrition; Tropical Diseases; Public Health
N2 - Recent events both here and abroad have focused attention on the need for ensuring a safe and secure food supply. Although much has been written about the potential of particular select agents in bioterrorism, we must consider seriously the more mundane pathogens, especially those that have been implicated previously in foodborne outbreaks of human disease, as possible agents of bioterrorism. Given their evolutionary history, the enteric pathogens are more diverse than agents such as Bacillus anthracis, Francisella tularensis, or Yersinia pestis. This greater diversity, however, is a double-edged sword; although diversity affords the opportunity for unequivocal identification of an organism without the need for whole-genome sequencing, the same diversity can confound definitive forensic identification if boundaries are not well defined. Here, we discuss molecular approaches used for the identification of Salmonella enterica, Escherichia coli, and Shigella spp. and viral pathogens and discuss the utility of these approaches to the field of microbial molecular forensics.
KW - analytical methods
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - terrorism
KW - Bacillus anthracis
KW - Escherichia coli
KW - Francisella tularensis
KW - man
KW - Salmonella
KW - Shigella
KW - viruses
KW - Yersinia pestis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Yersinia (Bacteria)
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053116913&site=ehost-live&scope=site
UR - email: tcebula@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Feasibility of immunodiagnostic devices for the detection of ricin, amanitin, and T-2 toxin in food.
AU - Garber, E. A. E.
AU - Eppley, R. M.
AU - Stack, M. E.
AU - McLaughlin, M. A.
AU - Park, D. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 6
SP - 1294
EP - 1301
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Garber, E. A. E.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, Division of Natural Products, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053116915. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9009-86-3, 21259-20-1. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology; Dairy Science; Human Nutrition
N2 - Qualitative and quantitative comparisons were conducted of commercially available immunodiagnostic devices for the detection of three select agents with oral LD50 values ≥0.1 mg/kg of body weight. Ricin (oral LD50>1 mg/kg), amanitin (oral LD50 approximately 0.1 mg/kg), and T-2 toxin (oral LD50>1 mg/kg) were spiked into beverages, produce, dairy, and baked goods and assayed using commercially available enzyme-linked immunosorbent assays (ELISAs) and lateral flow devices. In all cases, the commercial diagnostic kits successfully detected all three select agents at concentrations below what might be a health concern. The considerable difference between the limit of detection of the immunodiagnostic devices employed (typically ≤0.020 µg/g) and the amount of the select agent necessary to pose a health threat in a single serving of food facilitated the design of protocols for the high throughput screening of food samples. These protocols entailed simple extraction methods followed by sample dilution. Lateral flow devices and sandwich ELISAs for the detection of ricin had no significant background problems due to the food matrices. Competitive ELISAs, which typically have unacceptably high background reactions with food samples, successfully detected amanitin and T-2 toxin.
KW - analytical methods
KW - bakery products
KW - beverages
KW - ELISA
KW - food contamination
KW - fruits
KW - microbial contamination
KW - milk products
KW - mycotoxins
KW - ricin
KW - T-2 toxin
KW - vegetables
KW - amanitin
KW - analytical techniques
KW - baked goods
KW - dairy products
KW - drinks
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - fungal toxins
KW - fusariotoxin
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053116915&site=ehost-live&scope=site
UR - email: egarber@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of Anisakis simplex in arrowtooth flounder (Atheresthes stomia) during frozen storage.
AU - Adams, A. M.
AU - Ton, M. N.
AU - Wekell, M. M.
AU - MacKenzie, A. P.
AU - Dong, F. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 7
SP - 1441
EP - 1446
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Adams, A. M.: U.S. Food and Drug Administration, Seafood Products Research Center, P.O. Box 3012, 22201 23rd Drive S.E., Bothell, WA 98041-3012, USA.
N1 - Accession Number: 20053145684. Publication Type: Journal Article. Language: English. Subject Subsets: Helminthology
N2 - The survival of naturally occurring Anisakis simplex larvae in fresh arrowtooth flounder (Atheresthes stomia) obtained from Alaska, USA or Canada was determined after storage for specified periods at 4 freezing temperatures. All larvae were killed at 96, 60, 12 and 9 h at -15, -20, -30 and -40°C, respectively. The average percentages of live larvae per fillet at the next shortest holding time were: 72 h at -15°C, 0-3%; 48 h at -20°C, 11-30%; 9 h at -30°C, 5%; and 6 h at -40°C, 0-3%. Larval survival was directly related to fillet thickness or weight (P≤0.05). Larval death was directly correlated to freezing temperatures. The holding time necessary to kill larval nematodes decreased as storage temperature decreased. The results suggest that freezing time and weight and thickness of the fillet are correlated with survival of A. simplex larvae in frozen arrowtooth flounder.
KW - fish
KW - food contamination
KW - freezing
KW - frozen storage
KW - nematode larvae
KW - seafoods
KW - survival
KW - temperature
KW - thickness
KW - weight
KW - Anisakis simplex
KW - Atheresthes
KW - flounder
KW - Anisakis
KW - Anisakidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Pleuronectidae
KW - Pleuronectiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - aquatic organisms
KW - aquatic animals
KW - Ascaridida
KW - Atheresthes stomia
KW - food contaminants
KW - nematodes
KW - Secernentea
KW - Aquatic Produce (QQ060)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053145684&site=ehost-live&scope=site
UR - email: aadams@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of Salmonella and Campylobacter contamination of whole, raw poultry on retail sale in Wales in 2003.
AU - Meldrum, R. J.
AU - Tucker, D.
AU - Smith, R. M. M.
AU - Edwards, C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 7
SP - 1447
EP - 1449
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20053145685. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition; Poultry
N2 - A survey of Salmonella and Campylobacter contamination of raw, whole chickens available to consumers in Wales, UK, was performed between March and December 2003. A total of 736 samples were taken, and overall contamination rates of 73.1% for Campylobacter and 5.7% for Salmonella were found. This survey followed a survey performed during 2001-02 by Welsh local authorities and the National Public Health Service for Wales that established updated baseline rates for both pathogens in raw, whole chicken available to consumers in Wales. This survey indicated no difference in Campylobacter rates between fresh and frozen samples or between samples taken from retailers and local butchers, but significant differences existed in Salmonella rates between fresh and frozen samples and between those sampled from retailers and butchers, with frozen chickens and samples taken from retailers having significantly higher rates. However, the difference in Salmonella isolation rate between retailers and butchers was due to differences in the proportions of fresh and frozen chickens sampled from these locations, with a significantly higher number of frozen chickens (with a higher Salmonella rate) being sampled from retailers. The results indicate that Campylobacter contamination is still the most important concern in raw chicken meat industry, however the prevalence of Salmonella at a rate of nearly 6% could not be disregarded.
KW - chicken meat
KW - food contamination
KW - fresh products
KW - frozen meat
KW - meat quality
KW - microbial contamination
KW - poultry
KW - retail marketing
KW - surveys
KW - UK
KW - Wales
KW - Campylobacter
KW - fowls
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - United Kingdom
KW - Marketing and Distribution (EE700)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053145685&site=ehost-live&scope=site
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of a new enrichment procedure for Shiga toxin-producing Escherichia coli with five standard methods.
AU - Grant, M. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 8
SP - 1593
EP - 1599
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Grant, M. A.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 23rd Drive S.E., Bothell, WA 98021, USA.
N1 - Accession Number: 20053157404. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - A new procedure for enrichment of Escherichia coli O157:H7 and other Shiga toxin-producing E. coli was compared to five standard methods: the British Public Health Laboratory Service, International Standard Method, U.S. Department of Agriculture, Canadian Health Products and Food Branch, and U.S. Food and Drug Administration. The new procedure was comparable to the standard methods in its ability to detect target cells inoculated into foods at ~1 CFU/g. Comparisons were also made of the ability of the six enrichment procedures to detect E. coli O157:H7 against a large background of competitor microorganisms. In these experiments the new procedure yielded more target cells than the other five enrichments by two to three orders of magnitude as determined by enumeration on sorbitol MacConkey agar with tellurite and cefixime and Rainbow agar with tellurite and novobiocin and by verification of presumptive colonies by real-time PCR. For example, the population of enterohemorrhagic E. coli strain 6341 recovered on sorbitol MacConkey agar with tellurite and cefixime after enrichment with the experimental method was 2.42×108 CFU/ml and 1.80×106 CFU/ml after enrichment with the Canadian Health Products and Food Branch method, the second most effective in this experiment. In addition, broth cultures resulting from each of the six enrichment procedures were used to prepare templates for real-time PCR detection of stx1/stx2. Resulting threshold cycle (Ct) values after the experimental enrichment were similar to positive control values, whereas the five standard methods produced delayed Ct values or were not detected.
KW - bacterial toxins
KW - culture techniques
KW - genes
KW - molecular genetics
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia coli
KW - bacterium
KW - biochemical genetics
KW - E. coli
KW - shiga toxins
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053157404&site=ehost-live&scope=site
UR - email: mike.grant@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbiological quality of ready-to-eat foods: results from a long-term surveillance program (1995 through 2003).
AU - Meldrum, R. J.
AU - Ribeiro, C. D.
AU - Smith, R. M. M.
AU - Walker, A. M.
AU - Simmons, M.
AU - Worthington, D.
AU - Edwards, C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 8
SP - 1654
EP - 1658
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service (NPHS) for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20053157413. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Human Nutrition
N2 - The coordination of food sampling activities across Wales, a part of the United Kingdom with a population of ~3 million, led to the establishment in 1995 of a coordinated food sampling programme designed to monitor on a long-term basis the microbiological quality and safety of specific ready-to-eat products. This surveillance system has been ongoing for 9 years and has generated a database of microbiological and associated demographic results for 15 228 ready-to-eat food samples. The food types that had the poorest overall results were sliced meats, unsliced poultry, sandwiches made without salad, and cakes made without dairy cream. For all food types, the overall unsatisfactory rate was 17% for aerobic colony counts, 1.6% for Escherichia coli, and 0.5% for Listeria spp. Overall unsatisfactory or unacceptable rates for pathogens such as Clostridium perfringens, Listeria monocytogenes, Bacillus cereus, and Staphylococcus aureus were all below 0.5%. No Campylobacter-positive samples, and only one Salmonella-positive sample were found. The analysis of the results show that the ready-to-eat food types sampled over the 9 years of the programme were generally of good microbiological quality when compared with current United Kingdom guidelines. The information contained in the database provides a baseline measurement of the microbial quality of a variety of ready-to-eat foods and allows environmental health officers and food microbiologists to generate hypotheses for targeted surveys or research work.
KW - convenience foods
KW - food contamination
KW - food safety
KW - microbial contamination
KW - UK
KW - Wales
KW - Bacillus cereus
KW - Campylobacter
KW - Clostridium perfringens
KW - Escherichia coli
KW - Listeria
KW - Listeria monocytogenes
KW - Salmonella
KW - Staphylococcus aureus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeriaceae
KW - Listeria
KW - Staphylococcus
KW - Staphylococcaceae
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - E. coli
KW - food contaminants
KW - ready-to-eat foods
KW - United Kingdom
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053157413&site=ehost-live&scope=site
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of crustacean DNA and species identification using a PCR-restriction fragment length polymorphism method.
AU - Brzezinski, J. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 9
SP - 1866
EP - 1873
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Brzezinski, J. L.: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20053179734. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health; Human Nutrition
N2 - The detection of potentially allergenic proteins, such as those derived from crustaceans, in food products is a major concern for the food processing industry. A PCR-restriction fragment length polymorphism (PCR-RFLP) method was designed to detect the presence of crustacean DNA in food products and to determine the species source of the DNA. This PCR assay amplifies an approximately 205-bp fragment of the 16S rRNA gene in crustacean species, including shrimp, crab, lobster, and crawfish. This reaction will not amplify DNA derived from mammals, such as cow and sheep. After amplification, the PCR product is digested with differential restriction endonucleases to determine the species source of the crustacean DNA. The specificity of this assay was demonstrated using four species of shrimp, three species of crab, and two species of lobster and crawfish. This assay is sensitive enough to detect crustacean DNA in a raw meat mixture containing <0.1% shrimp.
KW - allergens
KW - crayfish
KW - food allergies
KW - food contamination
KW - food safety
KW - human diseases
KW - lobsters
KW - methodology
KW - polymerase chain reaction
KW - restriction fragment length polymorphism
KW - seafoods
KW - shrimps
KW - crabs
KW - Crustacea
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - food contaminants
KW - food hypersensitivity
KW - methods
KW - PCR
KW - RFLP
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053179734&site=ehost-live&scope=site
UR - email: jennifer.brzezinski@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of Enterobacter sakazakii in a dehydrated powdered infant formula.
AU - Edelson-Mammel, S. G.
AU - Porteous, M. K.
AU - Buchanan, R. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 9
SP - 1900
EP - 1902
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Edelson-Mammel, S. G.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053179738. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - A quantity of dehydrated powdered infant formula was prepared to contain Enterobacter sakazakii strain 607 at approximately 106 CFU/ml when rehydrated according to the manufacturer's instructions. The survival of the microorganism in the dry formula was followed for 2 years, during which samples periodically were rehydrated and analysed for viable E. sakazakii. During the initial 5 months of storage at room temperature, viable counts declined approximately 2.4 log cycles. During the subsequent 19 months, the concentration of viable E. sakazakii declined an additional 1.0 log cycle. These results indicate that a small percentage of E. sakazakii cells can survive for extended periods in dehydrated powdered infant formula.
KW - dried milk
KW - food contamination
KW - infant formulae
KW - microbial contamination
KW - survival
KW - Enterobacter sakazakii
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - milk powder
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053179738&site=ehost-live&scope=site
UR - email: robert.buchanan@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Salmonella and the sanitary quality of aquacultured shrimp.
AU - Koonse, B.
AU - Burkhardt, W., III
AU - Chirtel, S.
AU - Hoskin, G. P.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 12
SP - 2527
EP - 2532
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Koonse, B.: Office of Seafood, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20063011284. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Human Nutrition; Animal Breeding
N2 - In this study, we examined the prevalence of Salmonella and coliform bacteria on shrimp aquaculture farms to develop guidelines or preventative measures for reducing Salmonella and fecal contamination on products harvested from these farms. The U.S. Food and Drug Administration, in conjunction with foreign government regulatory agencies, the aquaculture industry, and academia affiliates, analyzed 1,234 samples from 103 shrimp aquaculture farms representing six countries between July 2001 and June 2003 for fecal coliforms, Escherichia coli, and Salmonella. A significant relationship was found (P=0.0342) between the log number of fecal bacteria and the probability that any given sample would contain Salmonella. The likelihood of any given sample containing Salmonella was increased by 1.2 times with each 10-fold increase in either fecal coliform or E. coli concentration. The statistical relationship between Salmonella concentration and that of both fecal coliforms and E. coli was highest in grow-out pond water (P=0.0042 for fecal coliforms and P=0.0021 for E. coli). The likelihood of finding Salmonella in grow-out pond water increased 2.7 times with each log unit increase in fecal coliform concentration and 3.0 times with each log unit increase in E. coli concentration. Salmonella is not part of the natural flora of the shrimp culture environment nor is it inherently present in shrimp grow-out ponds. The occurrence of Salmonella bacteria in shrimp from aquaculture operations is related to the concentration of fecal bacteria in the source and grow-out pond water.
KW - aquaculture
KW - coliform bacteria
KW - faecal coliforms
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - seafoods
KW - shrimps
KW - Escherichia coli
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - food contaminants
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063011284&site=ehost-live&scope=site
UR - email: brett.koonse@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a rapid PCR-based method for the detection of animal material.
AU - Yancy, H. F.
AU - Mohla, A.
AU - Farrell, D. E.
AU - Myers, M. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 12
SP - 2651
EP - 2655
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Yancy, H. F.: Division of Animal Research, U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063011300. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 9007-49-2. Subject Subsets: Pig Science; Human Nutrition; Animal Nutrition
N2 - A rapid PCR-based analytical method for detection of animal-derived materials in complete feed was developed. Using a commercially available DNA forensic kit for the extraction of DNA from animal feed, a sensitive method was developed that was capable of detecting as little as 0.03% bovine meat and bone meal in complete feed in under 8 h of total assay time. The reduction in assay time was accomplished by reducing the DNA extraction time to 2 h and using the simpler cleanup procedure of the kit. Assay sensitivity can be increased to 0.006% by increasing the DNA extraction time to an overnight incubation of approximately 16 h. Examination of dairy feed samples containing either bovine meat and bone meal, porcine meat and bone meal, or lamb meal at a level of 0.1% (wt/wt basis) suggested that this method may be suitable for regulatory uses. The adoption of this commercially available kit for use with animal feeds yields an assay that is quicker and simpler to perform than a previously validated assay for the detection of animal proteins in animal feed.
KW - DNA
KW - feed of animal origin
KW - feeds
KW - food contamination
KW - food safety
KW - methodology
KW - polymerase chain reaction
KW - deoxyribonucleic acid
KW - feeding stuffs
KW - food contaminants
KW - methods
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063011300&site=ehost-live&scope=site
UR - email: mmyers@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of two commercial lateral-flow test kits for detection of animal proteins in animal feed.
AU - Myers, M. J.
AU - Yancy, H. F.
AU - Farrell, D. E.
AU - Washington, J. D.
AU - Frobish, R. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005///
VL - 68
IS - 12
SP - 2656
EP - 2664
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Myers, M. J.: Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063011301. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - Performance characteristics were evaluated for two lateral-flow test kits, Reveal for Ruminant in Feed (Neogen Corporation) and FeedChek (Strategic Diagnostics Inc.), designed to detect ruminant or terrestrial animal proteins in feeds. The stringent acceptance criteria used were developed by the Center for Veterinary Medicine Office of Research to identify test kits with comparable selectivity and sensitivity to microscopy and PCR assay, the analytical methods used by the U.S. Food and Drug Administration (FDA). Guidelines were developed for evaluating the selectivity, sensitivity, ruggedness, and specificity of these kits. These guidelines further stated that ruggedness and specificity testing would be performed only after a test passed both the selectivity and sensitivity assessments. Acceptance criteria for determining success were developed using a statistical approach requiring 90% probability of achieving the correct response, within a 95% confidence interval. A minimum detection level of 0.1% bovine meat and bone meal, consistent with the sensitivity of the methods used by the FDA, was required. Selectivity was assessed by testing 60 dairy feed samples that contained no added animal proteins; sensitivity was determined by evaluating 60 samples (per level of fortification) of the same feed that contained 0.025, 0.05, 0.1, 0.25, 0.5, 1, or 2% bovine meat and bone meal. The Reveal test passed the selectivity assessment but failed the sensitivity assessment, detecting only samples fortified at the 2% level and then only 17 to 33% of those samples, when read according to the label directions. The FeedChek test passed the sensitivity assessment but failed the selectivity assessment, with rates for false-positive results ranging from 34 to 38%, depending on the user. The sensitivity of the Reveal test was affected by the concentration of trace minerals present in the feed; concentrations toward the high end of the normal range prevented the detection of true positive feed samples containing bovine meat and bone meal. Better sensitivity assessments were obtained when lamb meal was used either alone or in combination with bovine meat and bone meal. The FeedChek test was not affected by the concentration of trace minerals or by the type of animal meal used. These results indicate that neither of the two tests is adequate for routine regulatory use.
KW - bone meal
KW - feed of animal origin
KW - feeds
KW - food contamination
KW - food safety
KW - methodology
KW - feeding stuffs
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063011301&site=ehost-live&scope=site
UR - email: mmyers@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multigeneration reproductive and developmental toxicity study of bar gene inserted into genetically modified potato on rats.
AU - Rhee GyuSeek
AU - Cho DaeHyun
AU - Won YongHyuck
AU - Seok JiHyun
AU - Kim SoonSun
AU - Kwack SeungJun
AU - Lee RheeDa
AU - Chae SooYeong
AU - Kim JaeWoo
AU - Lee ByungMu
AU - Park KuiLea
AU - Choi KwangSik
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2005///
VL - 68
IS - 23/24
SP - 2263
EP - 2276
CY - London; UK
PB - Taylor & Francis
SN - 1528-7394
AD - Rhee GyuSeek: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20053207129. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Horticultural Science; Agricultural Biotechnology; Plant Breeding; Potatoes
N2 - Each specific protein has an individual gene encoding it, and a foreign gene introduced to a plant can be used to synthesize a new protein. The identification of potential reproductive and developmental toxicity from novel proteins produced by genetically modified (GM) crops is a difficult task. A science-based risk assessment is needed in order to use GM crops as a conventional foodstuff. In this study, the specific characteristics of GM food and low-level chronic exposure were examined using a five-generation animal study. In each generation, rats were fed a solid pellet containing 5% GM potato and non-GM potato for 10 weeks prior to mating in order to assess the potential reproductive and developmental toxic effects. In the multigeneration animal study, there were no GM potato-related changes in body weight, food consumption, reproductive performance, and organ weight. Polymerase chain reaction was carried out using extracted genomic DNA to examine the possibility of gene persistence in the organ tissues after a long-term exposure to low levels of GM feed. In each generation, the gene responsible for bar was not found in any of the reproductive organs of the GM potato-treated male and female rats, and the litter-related indexes did not show any genetically modified organism-related changes. The results suggest that genetically modified crops have no adverse effects on the multigeneration reproductive-developmental ability.
KW - biological development
KW - body weight
KW - food consumption
KW - genes
KW - genetically engineered organisms
KW - organs
KW - potatoes
KW - reproductive performance
KW - risk assessment
KW - safety
KW - toxicity
KW - transgenic plants
KW - plants
KW - rats
KW - Solanum tuberosum
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - genetically engineered plants
KW - genetically modified organisms
KW - genetically modified plants
KW - GEOs
KW - GMOs
KW - Field Crops (FF005) (New March 2000)
KW - Plant Breeding and Genetics (FF020)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053207129&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: cksos@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of estrogenic and androgenic activities of tetramethrin in vitro and in vivo assays.
AU - Kim SoonSun
AU - Kwack SeungJun
AU - Lee RheeDa
AU - Lim KwonJo
AU - Rhee GyuSeek
AU - Seok JiHyun
AU - Kim ByungHo
AU - Won YongHyuck
AU - Lee GeunShik
AU - Jeung EuiBae
AU - Lee ByungMu
AU - Park KuiLea
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2005///
VL - 68
IS - 23/24
SP - 2277
EP - 2289
CY - London; UK
PB - Taylor & Francis
SN - 1528-7394
AD - Kim SoonSun: Reproductive and Development Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20053207130. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 50-28-2, 7696-12-0.
N2 - Tetramethrin, a synthetic pyrethroid insecticide, is used globally for agriculture, and thus potential environmental exposure to tetramethrin is a concern. Environmental chemicals that are hormonally active (particularly oestrogen or androgen) may adversely affect the reproductive and endocrine systems. However, little is known about the oestrogenic and androgenic activities of tetramethrin. In this study, uterine CaBP-9k gene expression assay and a uterotrophic assay were conducted for oestrogenic activity assessment of tetramethrin, and a Hershberger assay was conducted for androgenic activity. Oestrogen receptor (ERα and ERβ) protein levels were also measured in tetramethrin-treated rat uteri. Northern blot analysis showed reduction in uterine CaBP-9k mRNA levels in response to tetramethrin, as well as when rats were given both tetramethrin and 17β-estradiol (E2). In the uterotrophic assay using 18-day-old female Sprague-Dawley rats, subcutaneous treatment with tetramethrin (5 to 800 mg/kg/day) for 3 days led to a statistically significant decrease in absolute and relative uterine wet weights at all doses tested. Moreover, tetramethrin blocked the effect of E2 on uterine weights. In addition, tetramethrin reduced absolute and relative vaginal wet weights, and also inhibited the increases of vaginal weights produced by E2. Tetramethrin showed no androgenic on antiandrogenic activities in the Hershberger assay. These results suggest that tetramethrin might exert endocrine-disrupting effects on female rats through antioestrogenic action.
KW - animal models
KW - estradiol
KW - in vitro
KW - laboratory animals
KW - oestrogenic properties
KW - pyrethroid insecticides
KW - tetramethrin
KW - uterus
KW - vagina
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrogenic properties
KW - oestradiol
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053207130&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: sskeem@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High-pressure inactivation of hepatitis A virus within oysters.
AU - Calci, K. R.
AU - Meade, G. K.
AU - Tezloff, R. C.
AU - Kingsley, D. H.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2005///
VL - 71
IS - 1
SP - 339
EP - 343
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Calci, K. R.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama, USA.
N1 - Accession Number: 20053017877. Publication Type: Journal Article. Language: English. Number of References: 38 ref.
N2 - Previous results demonstrated that hepatitis A virus (HAV) could be inactivated by high hydrostatic pressure (HHP) (D. H. Kingsley, D. Hoover, E. Papafragkou, and G. P. Richards, J. Food Prot. 65:1605-1609, 2002); however, direct evaluation of HAV inactivation within contaminated oysters was not performed. In this study, we report confirmation that HAV within contaminated shellfish is inactivated by HHP. Shellfish were initially contaminated with HAV by using a flowthrough system. PFU reductions of >1, >2, and >3 log10 were observed for 1-min treatments at 350, 375, and 400 megapascals, respectively, within a temperature range of 8.7 to 10.3°C. Bioconcentration of nearly 6 log10 PFU of HAV per oyster was achieved under simulated natural conditions. These results suggest that HHP treatment of raw shellfish will be a viable strategy for the reduction of infectious HAV.
KW - food contamination
KW - microbial contamination
KW - oysters
KW - pressure treatment
KW - raw foods
KW - seafoods
KW - shellfish
KW - hepatitis A virus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - food contaminants
KW - virus inactivation
KW - Aquatic Produce (QQ060)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053017877&site=ehost-live&scope=site
UR - email: dkingsle@desu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of lateral-flow Clostridium botulinum neurotoxin detection kits for food analysis.
AU - Sharma, S. K.
AU - Eblen, B. S.
AU - Bull, R. L.
AU - Burr, D. H.
AU - Whiting, R. C.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2005///
VL - 71
IS - 7
SP - 3935
EP - 3941
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Sharma, S. K.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20053152834. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - The suitability and sensitivity of two in vitro lateral-flow assays for detecting Clostridium botulinum neurotoxins (BoNTs) in an assortment of foods were evaluated. Toxin extraction and preparation methods for various liquid, solid, and high-fat-content foods were developed. The lateral-flow assays, one developed by the Naval Medical Research Center (Silver Spring, MD) and the other by Alexeter Technologies (Gaithersburg, MD), are based on the immunodetection of BoNT types A, B, and E. The assays were found to be rapid and easy to perform with minimum requirements for laboratory equipment or skills. They can readily detect 10 ng/ml of BoNT types A and B and 20 ng/ml of BoNT type E. Compared to other in vitro detection methods, these assays are less sensitive, and the assessment of a result is strictly qualitative. However, the assay was found to be simple to use and to require minimal training. The assays successfully detected BoNT types A, B, and E in a wide variety of foods, suggesting their potential usefulness as a preliminary screening system for triaging food samples with elevated BoNT levels in the event of a C. botulinum contamination event.
KW - analytical methods
KW - detection
KW - food analysis
KW - food contamination
KW - foods
KW - immunoassay
KW - in vitro
KW - microbial contamination
KW - neurotoxins
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053152834&site=ehost-live&scope=site
UR - email: Shashi.Sharma@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine.
AU - Xie, H.
AU - Gursel, I.
AU - Ivins, B. E.
AU - Singh, M.
AU - O'Hagan, D. T.
AU - Ulmer, J. B.
AU - Klinman, D. M.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2005///
VL - 73
IS - 2
SP - 828
EP - 833
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Xie, H.: Section of Retroviral Immunology, Center for Biologics Evaluation Research, Food and Drug Administration, Bldg. 29A, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063036551. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) adsorbed onto cationic polylactide-co-glycolide (PLG) microparticles (CpG ODN-PLG) to accelerate and boost the protective immunity elicited by Anthrax Vaccine Adsorbed (AVA, the licensed human anthrax vaccine). The results indicate that coadministering CpG ODN-PLG with AVA induces a stronger and faster immunoglobulin G response against the protective antigen of anthrax than AVA alone. Immunized mice were protected from lethal anthrax challenge within 1 week of vaccination with CpG ODN-PLG plus AVA, with the level of protection correlating with serum immunoglobulin G anti-protective antigen titers.
KW - anthrax
KW - human diseases
KW - IgG
KW - immune response
KW - vaccination
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063036551&site=ehost-live&scope=site
UR - http://iai.asm.org/cgi/content/abstract/73/2/828
UR - email: Klinman@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preliminary observations on the efficacy of a recombinant multistage Plasmodium falciparum vaccine in Aotus nancymai monkeys.
AU - Collins, W. E.
AU - Galland, G. G.
AU - Barnwell, J. W.
AU - Udhayakumar, V.
AU - Sullivan, J. S.
AU - Nace, D.
AU - Tongren, J. E.
AU - Williams, T.
AU - Roberts, J.
AU - Shi, Y. P.
AU - Lal, A. A.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2005///
VL - 73
IS - 4
SP - 686
EP - 693
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Services, Mail Stop F-12, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 20053216857. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Subject Subsets: Protozoology
N2 - A vaccine trial was conducted to determine the efficacy of a multicomponent candidate vaccine, FALVAC-1, against Plasmodium falciparum in Aotus nancymai monkeys. After two immunizations, animals were challenged intravenously with parasites of the Vietnam Oak Knoll (FVO) strain of P. falciparum. The primary outcome was to determine the protective response of the monkeys to immunization with the FALVAC-1 antigen produced in baculovirus when combined with different adjuvants (alum, QS-21, ASO2a, CRL1005/oil, and CRL1005/saline) as compared with FALVAC-1 with FCA/FIA and antigen alone. When compared with the monkeys immunized with FALVAC-1 alone, FALVAC-1 with FCA/FIA reduced the mean parasite count (to Day 11), reduced the mean accumulated parasitemia (through Day 11), and extended the number of days to treatment. None of the other 5 antigen-adjuvant combinations were able to provide discernable levels of protection based on log(parasitemia) and log(cumulative parasitemia) to Day 11.
KW - animal models
KW - efficacy
KW - experimental infections
KW - immunity
KW - immunization
KW - laboratory animals
KW - malaria
KW - recombinant vaccines
KW - vaccination
KW - Aotus
KW - Aotus nancymai
KW - Plasmodium falciparum
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Aotus
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053216857&site=ehost-live&scope=site
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentas.
AU - Chaisavaneeyakorn, S.
AU - Lucchi, N.
AU - Abramowsky, C.
AU - Othoro, C.
AU - Chaiyaroj, S. C.
AU - Shi, Y. P.
AU - Nahlen, B. L.
AU - Peterson, D. S.
AU - Moore, J. M.
AU - Udhayakumar, V.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2005///
VL - 73
IS - 6
SP - 3287
EP - 3293
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Chaisavaneeyakorn, S.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20053115852. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Protozoology; Tropical Diseases
N2 - Previously, we have shown that macrophage migration inhibitory factor (MIF) was highly elevated in the placental intervillous blood (IVB) of Plasmodium falciparum-infected women. Here, we compared the expression of MIF in placental tissues obtained from P. falciparum-infected and -uninfected women. Immunoperoxidase staining showed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mononuclear cells, and amniotic epithelial cells, irrespective of their malaria infection status. Cytotrophoblast, villous stroma, and Hofbauer cells showed focal staining. Only amniotic epithelial and IVB mononuclear cells from P. falciparum-infected placentas exhibited significantly higher level of MIF expression than uninfected placentas. Stimulation of syncytilized human trophoblast BeWo cells with P. falciparum-infected erythrocytes that were selected to bind these cells resulted in significant increases in MIF secretion, whereas control erythrocytes, lipopolysaccharides, and synthetic β-hematin had minimal effect. These findings suggest that placental malaria modulates MIF expression in different placental compartments.
KW - amniotic fluid
KW - erythrocytes
KW - human diseases
KW - immunohistology
KW - lipopolysaccharides
KW - macrophages
KW - malaria
KW - placenta
KW - pregnancy
KW - protozoal infections
KW - trophoblast
KW - Kenya
KW - man
KW - Plasmodium falciparum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - beta-haematin
KW - blood red cells
KW - cytotrophoblast
KW - epithelial cells
KW - gestation
KW - Hofbauer cells
KW - migration inhibitory factor
KW - mononuclear cells
KW - protozoal diseases
KW - red blood cells
KW - syncytiotrophoblasts
KW - Human Reproduction and Development (VV060)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053115852&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: vxu0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs.
AU - Flynn, B.
AU - Wang, V.
AU - Sacks, D. L.
AU - Seder, R. A.
AU - Verthelyi, D.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2005///
VL - 73
IS - 8
SP - 4948
EP - 4954
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Flynn, B.: Division of Therapeutic Proteins, Center for Drug Evaluation and Review, Food and Drug Administration, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20063211613. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Protozoology
N2 - Oligodeoxynucleotides (ODN) containing CpG motifs mimic microbial DNA and are recognized by toll-like receptor 9 on immune cells. The resulting response limits the early spread of infectious organisms and promotes the development of adaptive immunity. In this regard, CpG ODN show promise as immunoprotective agents and as vaccine adjuvants. Previous studies of nonhuman primates showed that administration of CpG ODN type D (also known as type A) at the site of infection 3 days before and after a challenge with Leishmania major enhanced host resistance and reduced the lesion's severity. In this study, we show that systemic administration of D/A ODN limits the size of lesions following an intradermal infection with L. major. Importantly, the reduced morbidity was not associated with a reduction in long-term immunity, as such treated macaques were still protected following a secondary challenge. Finally, administration of D/A ODN to macaques that had established cutaneous lesions reduced the severity of the lesions, suggesting a potential role for CpG ODN in L. major treatment. Together, these findings support the development of clinical studies to assess the use of CpG ODN types D/A as immunoprotective and therapeutic agents.
KW - cutaneous leishmaniasis
KW - disease models
KW - disease prevention
KW - experimental infections
KW - human diseases
KW - immunity
KW - immunotherapy
KW - laboratory animals
KW - medical treatment
KW - oligonucleotides
KW - Leishmania major
KW - Macaca mulatta
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063211613&site=ehost-live&scope=site
UR - http://iai.asm.org/cgi/content/abstract/73/8/4948
UR - email: Verthelyi@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Importance of srtA and srtB for growth of Bacillus anthracis in macrophages.
AU - Zink, S. D.
AU - Burns, D. L.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2005///
VL - 73
IS - 8
SP - 5222
EP - 5228
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Zink, S. D.: Laboratory of Respiratory and Special Pathogens, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063211632. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - We examined the effect of mutation of two sortase genes of Bacillus anthracis, srtA and srtB, on the ability of the bacterium to grow in J774A.1 cells, a mouse macrophage-like cell line. While disruption of either srtA or srtB had no effect on the ability of the bacteria to grow in rich culture media, mutations in each of these genes dramatically attenuated growth of the bacterium in J774A.1 cells. Complementation of the mutation restored the ability of bacteria to grow in the cells. Since the initial events in inhalation anthrax are believed to be uptake of B. anthracis spores by alveolar macrophages followed by germination of the spores and growth of the bacteria within the macrophages, these results suggest that two sortases of B. anthracis may be critical in the early stages of inhalation anthrax.
KW - drug targets
KW - gene expression
KW - genes
KW - growth
KW - in vitro
KW - macrophages
KW - molecular genetics
KW - mutants
KW - mutations
KW - virulence
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063211632&site=ehost-live&scope=site
UR - http://iai.asm.org/cgi/content/abstract/73/8/5222
UR - email: burns@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domain.
AU - Mahajan, B.
AU - Jani, D.
AU - Chattopadhyay, R.
AU - Nagarkatti, R.
AU - Zheng, H.
AU - Majam, V.
AU - Weiss, W.
AU - Kumar, S.
AU - Rathore, D.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2005///
VL - 73
IS - 9
SP - 5402
EP - 5409
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Mahajan, B.: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20053175665. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Protozoology; Public Health
N2 - Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the partially completed genome sequence of the simian malaria parasite Plasmodium knowlesi, we have identified a 786-bp DNA sequence that encodes a 262-amino-acid-long protein, containing an altered version of the thrombospondin type I repeat domain (SPATR). Thrombospondin type 1 repeat domains participate in biologically diverse functions, such as cell attachment, mobility, proliferation, and extracellular protease activities. The SPATR from P. knowlesi (PkSPATR) shares 61% and 58% sequence identity with its Plasmodium falciparum and Plasmodium yoelii orthologs, respectively. By immunofluorescence analysis, we determined that PkSPATR is a multistage antigen that is expressed on the surface of P. knowlesi sporozoite and erythrocytic stage parasites. Recombinant PkSPATR produced in Escherichia coli binds to a human hepatoma cell line, HepG2, suggesting that PkSPATR is a parasite ligand that could be involved in sporozoite invasion of liver cells. Furthermore, recombinant PkSPATR reacted with pooled sera from P. knowlesi-infected rhesus monkeys, indicating that native PkSPATR is immunogenic during infection. Further efficacy evaluation studies in the P. knowlesi-rhesus monkey sporozoite challenge model will help to decide whether the SPATR molecule should be developed as a vaccine against human malarias.
KW - antigens
KW - cell lines
KW - erythrocytes
KW - genes
KW - genomes
KW - hepatoma
KW - human diseases
KW - ligands
KW - liver
KW - liver cells
KW - liver diseases
KW - malaria
KW - nucleotide sequences
KW - protozoal infections
KW - recombinant proteins
KW - sporozoites
KW - surface proteins
KW - Escherichia coli
KW - Plasmodium falciparum
KW - Plasmodium knowlesi
KW - Plasmodium yoelii
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - antigenicity
KW - bacterium
KW - blood red cells
KW - DNA sequences
KW - E. coli
KW - hepatocytes
KW - immunogens
KW - membrane proteins
KW - protozoal diseases
KW - red blood cells
KW - thrombospondin
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053175665&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: kumars@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dominating prevalence of P[8],G1 and P[8],G9 rotavirus strains among children admitted to hospital between 2000 and 2003 in Budapest, Hungary.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Schipp, R.
AU - Jakab, F.
AU - Meleg, E.
AU - Mihály, I.
AU - Szücs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2005///
VL - 76
IS - 3
SP - 414
EP - 423
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadsás út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20053113829. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Public Health
N2 - Group A rotaviruses are the main cause of acute dehydrating diarrhoea in children, responsible for high mortality in developing countries and a significant socio-economic burden associated with treating the disease in developed countries. Two rotavirus vaccine candidates predicated on either homotypic or heterotypic protection have undergone clinical trials recently and await licensure for routine use. In anticipation of a future vaccination campaign in Hungary, the diversity of rotaviruses collected from Budapest between 2000 and 2003 were analysed by polyacrylamide gel electrophoresis (PAGE) of the viral genome and by serotyping and genotyping of the outer capsid genes, VP7 and VP4. Among 2,763 rotavirus positive specimens available for analysis, we were able to determine the electropherotype of 2,227, and, of these, 1,517 (68.1%) were subjected to G typing and 1,173 (52.7%) were subjected to P typing. We successfully G typed 1,481 (97.6%) and P typed 1,130 (96.3%) strains, respectively. A total of six G types (G1, 50.2%; G2, 2.2%; G3, 1.7%; G4, 5.8%; G6, 0.6%; and G9, 34.4%) and four P types (P[4], 3.0%; P[6], 0.7%; P[8], 89.9%; and P[9], 1.7%) were identified in nine individual combinations (P[8],G1; P[4],G2; P[8],G3; P[8],G4; P[8],G9; P[6],G4; P[4],G1; P[9],G3; and P[9],G6). The prevalence of VP7 and VP4 specificities varied from year to year. In this regard, a shift in serotype predominance from G1 in 2000-2001 (61.8%) and 2001-2002 (69.7%) to G9 in 2002-2003 (51.3%) was an intriguing observation that has been reported recently in some other countries, as well. The emergence of serotype G9 rotaviruses in Hungary and other parts of the world may have implications for future vaccine development and use, particularly, if current vaccine candidates cannot confer adequate homotypic or heterotypic protection against these strains.
KW - children
KW - diarrhoea
KW - gastroenteritis
KW - genes
KW - genotypes
KW - human diseases
KW - molecular epidemiology
KW - molecular genetics
KW - serotypes
KW - strains
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - diarrhea
KW - scouring
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053113829&site=ehost-live&scope=site
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - emerging new-variant and recombinant noroviruses in Hungary.
AU - Reuter, G.
AU - Krisztalovics, K.
AU - Vennema, H.
AU - Koopmans, M.
AU - Szucs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2005///
VL - 76
IS - 4
SP - 598
EP - 607
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20053140723. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Between January 2001 and December 2003, stool specimens from 262 (45%) of 581 reported outbreaks of gastroenteritis were investigated for noroviruses in Hungary. Specimens collected from outbreaks of non-bacterial gastroenteritis were examined by reverse-transcription polymerase chain reaction and enzyme immunoassay. In 253 (97%) of 262 outbreaks, norovirus was detected and confirmed by sequencing in 211 (81%). Hospitals (35%), day care centers (30%), and elderly homes (27%) were the most common settings. Diversity and frequency of the genotypes changed over time but with predominance (95%) of genogroup (GG) II strains. Strains grouped into 11 genotypes including an epidemic spread of new-variant GGII4 (Lordsdale virus) and a recently emerged group of natural recombinant strains (GGIIb/Hilversum polymerase) with four capsid types (Hawaii, Mexico, Snow Mountain, and Lordsdale). Clusters of epidemics including food-borne outbreaks were detected. According to this study, noroviruses are the predominant etiological agents causing gastroenteritis outbreaks in Hungary.
KW - aetiology
KW - emerging infectious diseases
KW - food contamination
KW - food poisoning
KW - foodborne diseases
KW - gastroenteritis
KW - human diseases
KW - strains
KW - viral diseases
KW - Hungary
KW - Caliciviridae
KW - man
KW - Norovirus
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - causal agents
KW - emerging diseases
KW - emerging infections
KW - etiology
KW - food contaminants
KW - viral infections
KW - winter vomiting disease
KW - winter vomiting virus
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053140723&site=ehost-live&scope=site
UR - email: reuterg@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spread of vaccine-derived poliovirus from a paralytic case in an immunodeficient child: an insight into the natural evolution of oral polio vaccine.
AU - Cherkasova, E. A.
AU - Yakovenko, M. L.
AU - Rezapkin, G. V.
AU - Korotkova, E. A.
AU - Ivanova, O. E.
AU - Eremeeva, T. P.
AU - Krasnoproshina, L. I.
AU - Romanenkova, N. I.
AU - Rozaeva, N. R.
AU - Sirota, L.
AU - Agol, V. I.
AU - Chumakov, K. M.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005///
VL - 79
IS - 2
SP - 1062
EP - 1070
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Cherkasova, E. A.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20063032497. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - Sabin strains used in the manufacture of oral polio vaccine (OPV) replicate in the human organism and can give rise to vaccine-derived polioviruses. The increased neurovirulence of vaccine derivatives has been known since the beginning of OPV use, but their ability to establish circulation in communities has been recognized only recently during the latest stages of the polio eradication campaign. This important observation called for studies of their emergence and evolution as well as extensive surveillance to determine the scope of this phenomenon. Here, we present the results of a study of vaccine-derived isolates from an immunocompromised poliomyelitis patient, the contacts, and the local sewage. All isolates were identified as closely related and slightly evolved vaccine derivatives with a recombinant type 2/type 1 genome. The strains also shared several amino acid substitutions including a mutation in the VP1 protein that was previously shown to be associated with the loss of attenuation. Another mutation in the VP3 protein resulted in altered immunological properties of the isolates, possibly facilitating virus spread in immunized populations. The patterns and rates of the accumulation of synonymous mutations in isolates collected from the patient over the extended period of excretion suggest either a substantially non-uniform rate of mutagenesis throughout the genome, or, more likely, the strains may have been intratypic recombinants between coevolving derivatives with different degrees of divergence from the vaccine parent. This study provides insight into the early stages of the establishment of circulation by runaway vaccine strains.
KW - disease transmission
KW - human diseases
KW - immunization
KW - immunocompromised hosts
KW - opportunistic infections
KW - paralysis
KW - poliomyelitis
KW - vaccination
KW - vaccines
KW - virulence
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - immune sensitization
KW - polio
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063032497&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/content/abstract/79/2/1062
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The topology of bulges in the long stem of the flavivirus 3′ stem-loop is a major determinant of RNA replication competence.
AU - Yu, L.
AU - Markoff, L.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005///
VL - 79
IS - 4
SP - 2309
EP - 2324
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Yu, L.: Laboratory of Vector-Borne Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063033001. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 63231-63-0. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Public Health
N2 - All flavivirus genomes contain a 3′terminal stem-loop secondary structure (3′SL) formed by the most downstream ~100 nucleotides (nt) of the viral RNA. The 3′SL is required for virus replication and has been shown to bind both virus-coded and cellular proteins. Results of the present study using an infectious DNA for WN virus strain 956 initially demonstrated that the dengue virus serotype 2 (DEN2) 3′SL nucleotide sequence could not substitute for that of the WN 3′SL to support WN genome replication. To determine what WN virus-specific 3′SL nucleotide sequences were required for WN virus replication, WN virus 3′SL nucleotide sequences were selectively deleted and replaced by analogous segments of the DEN2 3′SL nucleotide sequence such that the overall 3′SL secondary structure was not disrupted. Top and bottom portions of the WN virus 3′SL were defined according to previous studies (J. L. Blackwell and M. A. Brinton, J. Virol. 71:6433-6444, 1997; L. Zeng, L., B. Falgout, and L. Markoff, J. Virol. 72:7510-7522, 1998). A bulge in the top portion of the long stem of the WN 3′SL was essential for replication of mutant WN RNAs, and replication-defective RNAs failed to produce negative strands in transfected cells. Introduction of a second bulge into the bottom portion of the long stem of the wild-type WN 3′SL markedly enhanced the replication competence of WN virus in mosquito cells but had no effect on replication in mammalian cells. This second bulge was identified as a host cell-specific enhancer of flavivirus replication. Results suggested that bulges and their topological location within the long stem of the 3′SL are primary determinants of replication competence for flavivirus genomes.
KW - dengue
KW - human diseases
KW - nucleotide sequences
KW - replication
KW - RNA
KW - West Nile fever
KW - Dengue virus
KW - Flavivirus
KW - man
KW - West Nile virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - ribonucleic acid
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063033001&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/content/abstract/79/4/2309
UR - email: markoff@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inhibition of dengue virus serotypes 1 to 4 in Vero cell cultures with morpholino oligomers.
AU - Kinney, R. M.
AU - Huang, C. Y. H.
AU - Rose, B. C.
AU - Kroeker, A. D.
AU - Dreher, T. W.
AU - Iversen, P. L.
AU - Stein, D. A.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005///
VL - 79
IS - 8
SP - 5116
EP - 5128
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Kinney, R. M.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, USA.
N1 - Accession Number: 20063035427. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Public Health
N2 - Five dengue (DEN) virus-specific R5F2R4 peptide-conjugated phosphorodiamidate morpholino oligomers (P4-PMOs) were evaluated for their ability to inhibit replication of DEN virus serotype 2 (DEN-2 virus) in mammalian cell culture. Initial growth curves of DEN-2 virus 16681 were obtained in Vero cells incubated with 20 µM P4-PMO compounds. At 6 days after infection, a P4-PMO targeting the 3′-terminal nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed relatively little suppression of DEN-2 virus titer (0.1 and 0.9 log10, respectively). P4-PMOs targeting the AUG translation start site region of the single open reading frame and the 5′ cyclization sequence region had moderate activity, generating 1.6- and 1.8-log10 reductions. Two P4-PMO compounds, 5′SL and 3′CS (targeting the 5′-terminal nucleotides and the 3′ cyclization sequence region, respectively), were highly efficacious, each reducing the viral titer by greater than 5.7 log10 compared to controls at 6 days after infection with DEN-2 virus. Further experiments showed that 5′SL and 3′CS inhibited DEN-2 virus replication in a dose-dependent and sequence-specific manner. Treatment with 10 µM 3′CS reduced the titers of all four DEN virus serotypes, i.e., DEN-1 (strain 16007), DEN-2 (16681), DEN-3 (16562), and DEN-4 (1036) viruses by over 4 log10, in most cases to below detectable limits. The extent of 3′CS efficacy was affected by the timing of compound application in relation to viral infection of the cells. The 5′SL and 3′CS P4-PMOs did not suppress the replication of West Nile virus NY99 in Vero cells. These data indicate that further evaluation of the 5′SL and 3′CS compounds as potential DEN virus therapeutics is warranted.
KW - dengue
KW - human diseases
KW - nucleotide sequences
KW - phosphorodiamides
KW - replication
KW - serotypes
KW - translation
KW - Dengue 1 virus
KW - Dengue 2 virus
KW - Dengue 3 virus
KW - Dengue 4 virus
KW - man
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - RNA translation
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063035427&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/content/abstract/79/8/5116
UR - email: steind@avibio.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus.
AU - Huang, C. Y. H.
AU - Silengo, S. J.
AU - Whiteman, M. C.
AU - Kinney, R. M.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005///
VL - 79
IS - 12
SP - 7300
EP - 7310
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Huang, C. Y. H.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063035470. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - Chimeric dengue serotype 2/West Nile (D2/WN) viruses expressing prM-E of WN NY99 virus in the genetic background of wild-type D2 16681 virus and two candidate D2 PDK-53 vaccine variants (PDK53-E and PDK53-V) were engineered. The viability of the D2/WN viruses required incorporation of the WN virus-specific signal sequence for prM. Introduction of two mutations at M-58 and E-191 in the chimeric cDNA clones further improved the viability of the chimeras constructed in all three D2 carriers. Two D2/WN chimeras (D2/WN-E2 and -V2) engineered in the backbone of the PDK53-E and -V viruses retained all of the PDK-53 vaccine characteristic phenotypic markers of attenuation and were immunogenic in mice and protected mice from a high-dose 107 PFU challenge with wild-type WN NY99 virus. This report further supports application of the genetic background of the D2 PDK-53 virus as a carrier for development of live-attenuated, chimeric flavivirus vaccines in general and the development of a chimeric D2/WN vaccine virus against WN disease in particular.
KW - animal models
KW - candidate vaccines
KW - chimaeras
KW - dengue
KW - immunity
KW - laboratory animals
KW - mutations
KW - phenotypes
KW - serotypes
KW - Dengue 2 virus
KW - Flavivirus
KW - mice
KW - West Nile virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chimeras
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063035470&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/content/abstract/79/12/7300
UR - email: CHuang1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A prediction rule for selective screening of Chlamydia trachomatis infection.
AU - Götz, H. M.
AU - Bergen, J. E. A. M. van
AU - Veldhuijzen, I. K.
AU - Broer, J.
AU - Hoebe, C. J. P. A.
AU - Richardus, J. H.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2005///
VL - 81
IS - 1
SP - 24
EP - 30
CY - London; UK
PB - BMJ Publishing Group
SN - 1368-4973
AD - Götz, H. M.: Municipal Public Health Service Rotterdam, Department of Infectious Disease, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20053026471. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Background: Screening for Chlamydia trachomatis infections is aimed at the reduction of these infections and subsequent complications. Selective screening may increase the cost effectiveness of a screening programme. Few population based systematic screening programmes have been carried out and attempts to validate selective screening criteria have shown poor performance. This study describes the development of a prediction rule for estimating the risk of chlamydial infection as a basis for selective screening. Methods: A population based chlamydia screening study was performed in the Netherlands by inviting 21 000 15-29 year old women and men in urban and rural areas for home based urine testing. Multivariable logistic regression was used to identify risk factors for chlamydial infection among 6303 sexually active participants, and the discriminative ability was measured by the area under the receiver operating characteristic curve (AUC). Internal validity was assessed with bootstrap resampling techniques. Results: The prevalence of C. trachomatis (CT) infection was 2.6% (95% CI 2.2 to 3.2) in women and 2.0% (95% CI 1.4 to 2.7) in men. Chlamydial infection was associated with high level of urbanisation, young age, Surinam/Antillian ethnicity, low/intermediate education, multiple lifetime partners, a new contact in the previous two months, no condom use at last sexual contact, and complaints of (post)coital bleeding in women and frequent urination in men. A prediction model with these risk factors showed adequate discriminative ability at internal validation (AUC 0.78). Conclusion: The prediction rule has the potential to guide individuals in their choice of participation when offered chlamydia screening and is a promising tool for selective CT screening at population level. [The study described in this article and the preceeding one on p. 17-23 of the same issue of the journal is also described in a Dutch-language article published in Nederlands Tijdschrift voor Geneeskunde (2005) 149 (39) pp. 2167-2174].
KW - bacterial diseases
KW - human diseases
KW - risk
KW - screening
KW - sexually transmitted diseases
KW - Netherlands
KW - Chlamydia trachomatis
KW - man
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - screening tests
KW - STDs
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053026471&site=ehost-live&scope=site
UR - email: gotzh@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - UV doses worldwide.
AU - Godar, D. E.
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
Y1 - 2005///
VL - 81
IS - 4
SP - 736
EP - 749
CY - Augusta; USA
PB - American Society of Photobiology
SN - 0031-8655
AD - Godar, D. E.: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053166678. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - UV radiation affects human health. Human exposure to UV radiation causes a few beneficial health effects like vitamin D3 formation but it causes many detrimental health effects: sunburn, ocular damage, photoaging, immune suppression, DNA damage and skin cancer. In countries with fair-skinned populations, skin cancer is the most diagnosed of all cancers. In the United States in 2002, there were over one million new skin cancer cases. That means one out of every 285 people got skin cancer. Skin cancer of fair-skinned individuals is increasing at an alarming rate (4-6% per year) around the world and has now reached so-called "pandemic" proportions. Thus, it is important to know what UV doses people around the world get throughout their lives. This review covers how the outdoor UV doses are weighted for different biological effects, the most commonly used measuring devices for terrestrial and personal UV doses, the natural and other effects on terrestrial and personal UV doses, the time people spend outside, their ambient exposures and the terrestrial and personal UV doses of adult outdoor and indoor workers as well as children and adolescents around the world. Overall, outdoor-working adults get about 10%, while indoor-working adults and children get about 3% (2-4%) of the total available annual UV (on a horizontal plane). People's UV doses increase with increasing altitude and decreasing latitude; most indoor-working adult Europeans get 10000-20000 J/m2 per year, Americans get 20000-30000 J/m2 per year and Australians are estimated to get 20000-50000 J/m2 per year (excluding vacation, which can increase the dose by 30% or more).
KW - adolescents
KW - adults
KW - children
KW - disease incidence
KW - exposure
KW - human diseases
KW - neoplasms
KW - skin cancer
KW - sunburn
KW - ultraviolet radiation
KW - Australia
KW - Europe
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - North America
KW - America
KW - cancers
KW - teenagers
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053166678&site=ehost-live&scope=site
UR - http://phot.allenpress.com/photonline/?request=get-abstract&doi=10.1562%2F2004-09-07-IR-308R.1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors for hepatitis B in an outbreak of hepatitis B and D among injection drug users.
AU - Bialek, S. R.
AU - Bower, W. A.
AU - Mottram, K.
AU - Purchase, D.
AU - Nakano, T.
AU - Nainan, O.
AU - Williams, I. T.
AU - Bell, B. P.
JO - Journal of Urban Health: Bulletin of the New York Academy of Medicine
JF - Journal of Urban Health: Bulletin of the New York Academy of Medicine
Y1 - 2005///
VL - 82
IS - 3
SP - 468
EP - 478
CY - Cary; USA
PB - Oxford University Press
SN - 1099-3460
AD - Bialek, S. R.: United States Public Health Service, Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Mail Stop G-37, Atlanta, GA 30333, USA.
N1 - Accession Number: 20053150758. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - During January-April, 2000, 12 cases of acute hepatitis B were reported in Pierce County, Washington, compared with seven in all of 1999. Seven (58.3%) case patients were injection drug users (IDUs), three of whom were coinfected with hepatitis D virus (HDV) and died of fulminant hepatitis. Vaccination clinics were implemented at the local health department and needle exchange program to control the outbreak. We investigated this outbreak to determine risk factors for hepatitis B virus (HBV) transmission among IDUs. Hepatitis B cases were ascertained through routine surveillance and prevaccination testing at vaccination clinics. We conducted a case-control study comparing IDU case patients with HBV-susceptible IDUs identified at the vaccination clinics. Fifty-eight case patients were identified during January-December, 2000, 20 (34.5%) of whom were coinfected with HDV. Thirty-eight case patients (65.5%) reported current IDU. In the case-control study, the 17 case patients were more likely than the 141 controls to report having more than one sex partner [odds ratio (OR)=4.8, 95% confidence interval (CI)=1.5-15.0], injecting more than four times a day (OR=4.5, 95% CI=1.2-15.6) and sharing drug cookers with more than two people (58.8% vs. 14.0%, OR=14.0, 95% CI=2.4-81.5). Results were similar after controlling for syringe sharing in multivariable analysis. IDUs should be vaccinated against hepatitis B and should be advised against sharing drug injection equipment.
KW - epidemiology
KW - hepatitis B
KW - hepatitis D
KW - human diseases
KW - injecting drug abuse
KW - injecting drug users
KW - liver
KW - liver diseases
KW - outbreaks
KW - risk factors
KW - District of Columbia
KW - USA
KW - hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Deltavirus
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - hepatitis D virus
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053150758&site=ehost-live&scope=site
UR - http://jurban.oupjournals.org/
UR - email: sbialek@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The tuberculosis vaccine challenge.
AU - Brennan, M. J.
T3 - Special Issue: TB Vaccines for the World
JO - Tuberculosis
JF - Tuberculosis
Y1 - 2005///
VL - 85
IS - 1/2
SP - 7
EP - 12
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1472-9792
AD - Brennan, M. J.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29 Rm 503 HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053040200. Publication Type: Journal Article. Note: Special Issue: TB Vaccines for the World Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - Although antibiotic treatments for tuberculosis (TB) are available, because of reinfection, drug resistance, acquired immune deficiency syndrome, and economic reasons, it is unlikely that we will be able to control the global spread of TB without an effective vaccine. A number of new candidate vaccines for TB are under development and some are being evaluated for safety in normal human subjects in clinical trials. Additional vaccine candidates have been shown to be safe and effective when administered prior to infection in animal models. However, in areas of the world where TB is endemic, up to two-thirds of the population are already infected with Mycobacterium tuberculosis, and it is unlikely that a new pre-exposure vaccine would have a substantial impact on disease for decades. In contrast, a vaccine that could be delivered to individuals already infected could reduce the disease burden. At this time, it is unclear whether the new TB vaccines can be safely and effectively used in populations already infected with M. tuberculosis, immunized with Bacillus Calmette-Guérin vaccine or infected with human immunodeficiency virus. This presents a major challenge to preclinical testing and clinical evaluation as well as eventual uptake of the new TB vaccines into areas of the world that are most at risk for TB.
KW - acquired immune deficiency syndrome
KW - antibiotics
KW - BCG vaccine
KW - candidate vaccines
KW - clinical trials
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - mycobacterial diseases
KW - safety
KW - tuberculosis
KW - vaccine development
KW - vaccines
KW - viral diseases
KW - man
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - AIDS
KW - bacterium
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mycobacterial infections
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053040200&site=ehost-live&scope=site
UR - http://www.harcourt-international.com/journals/tube/
UR - email: brennan@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and estimation of the levo isomer in raw materials and finished products containing atropine and/or hyoscyamine.
AU - Cieri, U. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 1
SP - 1
EP - 4
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Cieri, U. R.: U.S. Food and Drug Administration, 2nd and Chestnut Sts, Philadelphia, PA 19106, USA.
N1 - Accession Number: 20053049537. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 51-55-8, 55-48-1. Subject Subsets: Aromatic & Medicinal Plants
N2 - The belladonna alkaloids atropine sulfate and hyoscyamine sulfate, occasionally used as anticholinergic and antimuscarinic agents, have identical molecular formulas but different stereo configurations. Hyoscyamine sulfate contains almost 100% of the levo isomer, whereas atropine sulfate is composed of equal parts of dextro and levo isomers. It is believed that the therapeutic properties of these alkaloids are due exclusively or primarily to the levo isomer. Currently available methods determine only the total amount of atropine (hyoscyamine) sulfate. A method has been developed and is reported for the identification and estimation of the levo and dextro isomers of atropine and hyoscyamine. Reference solutions are prepared in methanol at the following weights per 100 mL: 8.0 mg atropine sulfate; 4.0 mg hyoscyamine sulfate; 7.0 mg scopolamine hydrobromide; and 10.0 mg homatropine methylbromide. Samples of raw materials are similarly prepared in methanol, commercial products are also extracted or diluted with methanol, and solutions are filtered. Liquid chromatography is used for separations on a 25 cm Chirobiotic T2 column. The mobile phase is prepared by mixing 3.0 mL acetic acid and 2.0 mL triethylamine with 1000 mL methanol. The injection volume is 100 or 200 µL; the flow rate is about 0.35 mL/min. Fluorescence detection is at 255 nm excitation and 285 nm emission. Scopolamine hydrobromide and hyoscyamine eluted after 20 and 60 min, respectively. Atropine sulfate generated 2 peaks after 60 and 65 min. Homatropine methylbromide also produced 2 peaks after 70 and 85 min. Samples tested in this study included raw materials and commercial tablets or injections containing belladonna alkaloids. In all cases, the percentage calculated was that of the levo isomer relative to the total amount of atropine (hyoscyamine) present.
KW - alkaloids
KW - analytical methods
KW - atropine
KW - food supplements
KW - isomers
KW - medicinal plants
KW - Atropa belladonna
KW - Atropa
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049537&site=ehost-live&scope=site
UR - email: ucieri@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
AU - Hu, L. H.
AU - Jhoo, J. W.
AU - Ang, C. Y. W.
AU - Dinovi, M.
AU - Mattia, A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 1
SP - 16
EP - 25
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hu, L. H.: Division of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, HFT-230, 3900 NCTR Rd, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053049544. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Kava (Piper methysticum) dietary products have been sold worldwide for treatment of nervous anxiety, tension, and restlessness. Recent reports showed potential association of kava usage and liver injuries. This study was conducted to develop simple and reliable methodologies for the extraction and determination of 6 major kavalactones: (+)-methysticin, (+)-dihydromethysticin, (+)-kavain, (+)-dihydrokavain, yangonin, and desmethoxy-yangonin. Ultrasonic extraction techniques and isocratic reversed-phase liquid chromatography (LC) were optimized for different types of samples, including capsules containing kava root extract or root powder, raw root material, tea bags, and snack bar. A suitable internal standard, 5,7-dihydroxyflavone, was used for LC calibration. Kavalactones were completely separated in 30 min using a Luna C18-2 column at 60°C with an isocratic mobile phase consisting of 2-propanol-acetonitrile-water-acetic acid (16+16+68+0.1, v/v/v/v). Within-laboratory, intraday, and interday method variation (% relative standard deviation) for most samples extracted by methanol or methanol-water mixture were <5%. Lower levels of kavalactone contents and higher variations were observed for tea bags from water extraction or infusion as compared to methanol extraction. Labeling information of tea bags based on methanol extraction could be misleading to consumers. Analytical recoveries of snack bar fortified at 10 and 20 µg/g were >84% with RSD values <8%. Methods developed in this study offer a simple and reproducible means for analysis of kavalactones in various matrixes of dietary products.
KW - analytical methods
KW - extraction
KW - food supplements
KW - liquid chromatography
KW - medicinal plants
KW - plant extracts
KW - Piper methysticum
KW - Piper
KW - Piperaceae
KW - Piperales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - drug plants
KW - kavalactones
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049544&site=ehost-live&scope=site
UR - email: cang@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic analysis of vitamin B6 in reconstituted infant formula: collaborative study.
AU - Mann, D. L.
AU - Ware, G. M.
AU - Bonnin, E.
AU - Eitenmiller, R. R.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 1
SP - 30
EP - 37
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mann, D. L.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20053049562. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 65-23-6. Subject Subsets: Dairy Science; Soyabeans; Human Nutrition
N2 - A liquid chromatographic (LC) method was validated for the determination of total vitamin B6 in infant formula. Total vitamin B6 was quantified by converting the phosphorylated and free vitamers into pyridoxine. Pyridoxine was determined by ion pair reversed-phase LC with fluorescence detection. The method was subjected to an AOAC collaborative study involving a factory-manufactured, milk- and soy-based infant formula. Each was spiked at 3 concentrations in the range of 0-1 µg/g and sent as blind duplicate to participant laboratories. Nine laboratories returned valid data which were statistically analyzed for outliers and precision parameters. The repeatability relative standard deviation (RSDr) ranges were 2.0-4.0 and 3.5-5.9% for fortified milk- and soy-based formulas, respectively. The reproducibility relative standard deviation (RSDR) ranges were 8.2-8.4 and 6.7-11.2% for fortified milk- and soy-based formulas, respectively. HORRAT values ranged from 0.42 to 0.53, indicating that the precision of the method is acceptable. The mean RSDr:RSDR values were 0.60 and 0.55 for milk- and soy-based formulas, respectively. As expected, RSDs for the unfortified samples were higher, but their HORRAT values (0.81 and 2.06) helped define a realistic limit of quantitation as 0.05 µg/g. Recovery data were quantitative and varied between 81.4 and 98.0% (mean=89.8%) for each of 6 spiked materials.
KW - analytical methods
KW - chemical composition
KW - infant formulae
KW - liquid chromatography
KW - milk
KW - pyridoxine
KW - soya milk
KW - soyabean products
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - soy milk
KW - soyabean milk
KW - soybean products
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049562&site=ehost-live&scope=site
UR - email: ebonnin@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Photomutagenicity of retinyl palmitate by ultraviolet A irradiation in mouse lymphoma cells.
AU - Mei, N.
AU - Xia, Q. S.
AU - Chen, L.
AU - Moore, M. M.
AU - Fu, P. P.
AU - Chen, T.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005///
VL - 88
IS - 1
SP - 142
EP - 149
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Mei, N.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053178730. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 68-26-8, 79-81-2. Subject Subsets: Human Nutrition
N2 - Retinyl palmitate (RP), a storage form of vitamin A, is frequently used as a cosmetic ingredient, with more than 700 RP-containing cosmetic products on the U.S. market in 2004. There are concerns for the possible genotoxicity and carcinogenicity of RP when it is exposed to sunlight. To evaluate the photomutagenicity of RP in cells when exposed to ultraviolet A (UVA) light, L5178Y/Tk+/- mouse lymphoma cells were treated with different doses of RP alone/or in the presence of UVA light. Treatment of the cells with RP alone at the dose range of 25-100 µg/ml did not increase mutant frequencies (MFs) over the negative control, whereas treatment of cells with 1-25 µg/ml RP under UVA light (82.8 mJ/cm2/min for 30 min) produced a dose-dependent mutation induction. The mean induced MF (392×10-6) for treatment with 25 µg/ml RP under UVA exposure was about threefold higher than that for UVA alone (122×10-6), a synergistic effect. To elucidate the underlying mechanism of action, we examined the mutants for loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11, on which the Tk gene is located. The mutational spectrum for the RP+UVA treatment was significantly different from the negative control, but not significantly different from UVA exposure alone. Ninety four percent of the mutants from RP+UVA treatment lost the Tk+ allele, and 91% of the deleted sequences extended more than 6 cM in chromosome length, indicating clastogenic events affecting a large segment of the chromosome. These results suggest that RP is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action.
KW - animal models
KW - carcinogens
KW - cosmetics
KW - human diseases
KW - irradiation
KW - laboratory animals
KW - lymphoma
KW - mutagenicity
KW - neoplasms
KW - retinol
KW - retinyl palmitate
KW - ultraviolet radiation
KW - USA
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - axerophthol
KW - cancers
KW - retinol palmitate
KW - United States of America
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053178730&site=ehost-live&scope=site
UR - http://toxsci.oupjournals.org/
UR - email: tchen@nctr.fda.gov\pfu@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Performance Tested MethodSM multiple laboratory validation study of ELISA-based assays for the detection of peanuts in food.
AU - Park, D. L.
AU - Coates, S.
AU - Brewer, V. A.
AU - Garber, E. A. E.
AU - Abouzied, M.
AU - Johnson, K.
AU - Ritter, B.
AU - McKenzie, D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 1
SP - 156
EP - 160
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Park, D. L.: Division of Natural Products, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20053049543. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Dairy Science; Postharvest Research; Human Nutrition; Public Health
N2 - Performance Tested MethodSM multiple laboratory validations for the detection of peanut protein in 4 different food matrixes were conducted under the auspices of the AOAC Research Institute. In this blind study, 3 commercially available ELISA test kits were validated: Neogen Veratox® for Peanut, R-Biopharm RIDASCREEN® FAST Peanut, and Tepnel BioKits for Peanut Assay. The food matrixes used were breakfast cereal, cookies, ice cream, and milk chocolate spiked at 0 and 5 ppm peanut. Analyses of the samples were conducted by laboratories representing industry and international and U.S governmental agencies. All 3 commercial test kits successfully identified spiked and peanut-free samples. The validation study required 60 analyses on test samples at the target level 5 µg peanut/g food and 60 analyses at a peanut-free level, which was designed to ensure that the lower 95% confidence limit for the sensitivity and specificity would not be <90%. The probability that a test sample contains an allergen given a prevalence rate of 5% and a positive test result using a single test kit analysis with 95% sensitivity and 95% specificity, which was demonstrated for these test kits, would be 50%. When 2 test kits are run simultaneously on all samples, the probability becomes 95%. It is therefore recommended that all field samples be analyzed with at least 2 of the validated kits.
KW - analytical methods
KW - bakery products
KW - breakfast cereals
KW - chemical composition
KW - chocolate
KW - ELISA
KW - food allergies
KW - food safety
KW - groundnut protein
KW - groundnuts
KW - human diseases
KW - ice cream
KW - milk products
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - baked goods
KW - dairy products
KW - enzyme linked immunosorbent assay
KW - food hypersensitivity
KW - peanut protein
KW - peanuts
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049543&site=ehost-live&scope=site
UR - email: dpark@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid phenotypic characterization of Vibrio isolates by pyrolysis metastable atom bombardment mass spectrometry.
AU - Wilkes, J. G.
AU - Rushing, L. G.
AU - Gagnon, J. F.
AU - McCarthy, S. A.
AU - Rafii, F.
AU - Khan, A. A.
AU - Kaysner, C. A.
AU - Heinze, T. M.
AU - Sutherland, J. B.
JO - Antonie van Leeuwenhoek
JF - Antonie van Leeuwenhoek
Y1 - 2005///
VL - 88
IS - 2
SP - 151
EP - 161
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0003-6072
AD - Wilkes, J. G.: Division of Systems Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053168251. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Public Health
N2 - Pyrolysis mass spectrometry was investigated for rapid characterization of food-borne bacterial pathogens. Nine isolates of Vibrio parahaemolyticus and one isolate each of Vibrio fluvialis, Vibrio hollisae, and Vibrio vulnificus were analyzed. Pyrolysis mass spectra, generated via an alternative ionization method, metastable atom bombardment, were subject to principal component-discriminant analysis. The spectral patterns were used to distinguish Vibrio isolates differing in species, serotype and expression of the thermostable direct hemolysin gene. The patterns of similarity and dissimilarity amongst spectra in the Vibrio test set generally reflected those associated with species, serotype or hemolysin-producing genes, though the combined influence of these and other variables in the multi-dimensional data did not produce a simple clustering with respect to any one of these characteristics. These results suggested that with enough examples to model the most common combinations, the method should be able to characterize Vibrio isolates according to their phenotypic characteristics. Pyrolysis-mass spectrometry with metastable atom bombardment and pattern recognition appeared suitable for rapid infraspecific comparison of Vibrio isolates. This integrated analytical, pattern-recognition system should be examined further for potential utility in clinical and public health diagnostic contexts.
KW - bacterial diseases
KW - diagnosis
KW - diagnostic techniques
KW - foodborne diseases
KW - human diseases
KW - mass spectrometry
KW - phenotypes
KW - Grimontia hollisae
KW - man
KW - Vibrio
KW - Vibrio fluvialis
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Vibrio
KW - Grimontia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Vibrio hollisae
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053168251&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=100234
UR - email: jwilkes@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Investigation of pyrrolizidine alkaloids and their N-oxides in commercial comfrey-containing products and botanical materials by liquid chromatography electrospray ionization mass spectrometry.
AU - Altamirano, J. C.
AU - Gratz, S. R.
AU - Wolnik, K. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 2
SP - 406
EP - 412
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Altamirano, J. C.: U.S. Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA.
N1 - Accession Number: 20053189606. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Pyrrolizidine alkaloids (PAs) and their N-oxides are found in several plant families throughout the world. PAs are potentially toxic to the liver and/or lungs in humans and may cause acute liver failure, cirrhosis, pneumonitis, or pulmonary hypertension. PAs are also carcinogenic to animals, and they have been linked to the development of hepatocellular and skin squamous cell carcinomas as well as liver angiosarcomas. According to experimental studies, the quantity of PAs in some herbal teas and dietary supplements is sufficient to be carcinogenic in exposed individuals. A method for the extraction and identification of PAs and their N-oxides in botanical materials and commercial comfrey (which includes Symphytum asperum, S. officinale, S. tuberosum and S. uplandicum)-containing products has been developed using liquid chromatography electrospray ionization mass spectrometry. Following optimization of the extraction procedure and the chromatographic conditions, the method was applied to the analysis of 10 herbal remedies. All of the products that were labelled to contain comfrey were found to contain measurable quantities of PAs.
KW - analytical methods
KW - herbal drugs
KW - medicinal plants
KW - oxides
KW - pyrrolizidine alkaloids
KW - Symphytum asperum
KW - Symphytum officinale
KW - Symphytum tuberosum
KW - Symphytum uplandicum
KW - Symphytum
KW - Boraginaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - Boraginales
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053189606&site=ehost-live&scope=site
UR - email: sgratz@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of sulfamethazine, sulfathiazole, and sulfadimethoxine residues in condensed milk and soft-cheese products by liquid chromatography/tandem mass spectrometry.
AU - Clark, S. B.
AU - Turnipseed, S. B.
AU - Madson, M. R.
AU - Hurlbut, J. A.
AU - Kuck, L. R.
AU - Sofos, J. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 3
SP - 736
EP - 743
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Clark, S. B.: U.S. Food and Drug Administration, PO Box 25087, Denver, CO 80225, USA.
N1 - Accession Number: 20053124864. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 122-11-2, 57-68-1, 72-14-0. Subject Subsets: Dairy Science; Veterinary Science; Veterinary Science
N2 - A liquid chromatography/tandem mass spectrometry method (LC/MS/MS) is described for the simultaneous detection of 3 sulfonamide drug residues at 1.25 ppb in condensed milk and soft-cheese products. The 3 sulfonamide drugs of interest are sulfathiazole (STZ), sulfamethazine (SMZ), and sulfadimethoxine (SDM). The method includes extraction of the product with phosphate buffer, centrifugation of the diluted product, and application of a portion of the extract onto a polymeric solid-phase extraction cartridge. The cartridge is washed with water, and the sulfonamides are eluted with methanol. After evaporation, the residue is dissolved in 0.1% formic acid solution, and the solution is filtered before analysis by LC/MS/MS. The LC/MS/MS program involved a series of time-scheduled selected-reaction monitoring transitions. The transitions of MH+ to the common product ions at m/z 156, 108, and 92 were monitored for each residue. In addition, SMZ and SDM had a fourth significant and unique product ion transition that could be measured. Validation was performed with control and fortified-control condensed bovine milk with 2.5, 5, and 10 ppb sulfonamides. This method was applied to imported flavored and unflavored condensed milk and cream cheese bars. The presence of STZ and SMZ residues was confirmed in 3 out of 6 products.
KW - condensed milk
KW - cream cheese
KW - detection
KW - drug residues
KW - liquid chromatography
KW - mass spectrometry
KW - soft cheese
KW - sulfadimethoxine
KW - sulfadimidine
KW - sulfathiazole
KW - sulfonamides
KW - sulfamethazine
KW - sulphadimethoxine
KW - sulphadimidine
KW - sulphathiazole
KW - sulphonamides
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053124864&site=ehost-live&scope=site
UR - email: sherri.turnipseed@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in cooked crab meat.
AU - Rupp, H. S.
AU - Stuart, J. S.
AU - Hurlbut, J. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 4
SP - 1155
EP - 1159
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Rupp, H. S.: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Dr SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20053146069. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 56-75-7. Subject Subsets: Human Nutrition
N2 - A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method is described for the extraction, cleanup, determination, and confirmation of chloramphenicol (CAP) in cooked crab meat. The method involves pulverization of cooked crab meat with dry ice; extraction of the CAP into ethyl acetate (EtOAc); evaporation (by N2) of the EtOAc; addition of methanol, aqueous NaCl, and heptane; extraction of the lipids into the heptane, followed by extraction of the aqueous phase with EtOAc; evaporation (by N2) of the EtOAc; dissolution into methanol-water; filtration; and separation/detection/confirmation using LC/MS/MS. Crab meat was fortified at 0.25, 0.50, and 1.0 ng/g (ppb) chloramphenicol. Average absolute recoveries were 67, 84, and 86%, respectively, with relative standard deviation values all less than 1%. Four daughter ions (m/z 152, 176, 194, and 257) were monitored off the m/z 321 precursor ion. Determination was based on a standard curve using the peak areas of the m/z 152 daughter ion (the base peak) for standard solutions equivalent to 0.10, 0.20, 0.50, and 1.0 ppb in tissue (made with control crab extract). A set of 6 matrix controls (unfortified crab meat) was also analyzed, in which no chloramphenicol was detected. For identification purposes, the ion ratios (of each daughter ion versus the base daughter ion) of the fortified crab versus those of the chloramphenicol standards agreed within 10% (relative) at fortified chloramphenicol concentrations of 0.25-1.0 ppb.
KW - analytical methods
KW - chloramphenicol
KW - crab meat
KW - determination
KW - drug residues
KW - liquid chromatography
KW - mass spectrometry
KW - methodology
KW - analytical techniques
KW - methods
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053146069&site=ehost-live&scope=site
UR - email: heidi.rupp@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of malachite green and leucomalachite green (LMG) residues in salmon with in situ LMG oxidation.
AU - Andersen, W. C.
AU - Roybal, J. E.
AU - Turnipseed, S. B.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 5
SP - 1292
EP - 1298
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Andersen, W. C.: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20053204714. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 569-64-2. Subject Subsets: Human Nutrition
N2 - A liquid chromatography (LC) method is presented for the quantitative determination of malachite green (MG) in salmon. MG and leucomalachite green (LMG) residues were extracted from salmon tissue with ammonium acetate buffer and acetonitrile, and then isolated by partitioning into dichloromethane. LMG was quantitatively oxidized to the chromic MG by reaction with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Samples were then cleaned up by solid-phase extraction with alumina and propylsulfonic acid phases. Extracts were analyzed for MG by LC with visible detection at 618 nm using isocratic elution and a C18 column. The method was validated in 35 farm-raised salmon (Salmo salar) tissues fortified at 1, 2, 4, and 10 ng/g (ppb) with an average recovery of 95.4% and a relative standard deviation of ±11.1%, and in 5 canned salmon (Oncorhynchus gorbuscha) samples fortified at 10 ng/g with an average recovery of 88.9±2.6%. This study also included the determination of MG and LMG residues in tissues from salmon that had been treated with MG. MG was quantitatively determined at the method detection limit of 1 ng/g.
KW - analytical methods
KW - determination
KW - food contamination
KW - liquid chromatography
KW - malachite green
KW - residues
KW - Oncorhynchus gorbuscha
KW - salmon
KW - Oncorhynchus
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - analytical techniques
KW - food contaminants
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053204714&site=ehost-live&scope=site
UR - email: wendy.andersen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of malachite green and leucomalachite green residues in salmon using liquid chromatography/mass spectrometry with no-discharge atmospheric pressure chemical ionization.
AU - Turnipseed, S. B.
AU - Andersen, W. C.
AU - Roybal, J. E.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 5
SP - 1312
EP - 1317
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Turnipseed, S. B.: U.S. Food and Drug Administration, Animal Drugs Research Center, PO Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20053204716. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 569-64-2. Subject Subsets: Human Nutrition
N2 - A liquid chromatography/mass spectrometry (LC/MS) method was developed to quantitate and confirm residues of leucomalachite green (LMG) in salmon tissue after their conversion to chromic malachite green (MG) in the extraction process. The method uses no-discharge atmospheric pressure chemical ionization (APCI) in conjunction with an ion-trap instrument to generate product-ion spectra. In the sample preparation procedure, salmon tissue is extracted with acetonitrile/buffer, the LMG residue is partitioned into methylene chloride, the LMG is converted to MG using an organic oxidizing agent, and the MG is isolated on alumina/propylsulfonic acid solid-phase extraction cartridges. The method was validated by fortifying salmon with different levels of LMG, and then detecting the residue as MG. The LC/MS conditions, including a comparison of electrospray and no-discharge APCI, were evaluated and optimized. MG was not confirmed in any of the control tissue extracts, and all fortified samples analyzed during validation met the confirmation criteria as described. In addition to providing confirmatory data, this method can provide an alternative method for quantitation of MG in salmon. The recoveries of LMG, measured as MG by this LC/MS method, at fortification levels of 1-10 ng/g were very high (86-109%), with low relative standard deviation(RSD) values (6.4-13%). The results agreed very closely with those obtained for the same extracts using an LC/VIS procedure, indicating that matrix suppression was not an issue. The presence of LMG in salmon tissue samples fortified at 0.25 ng/g was confirmed by this method, with an average recovery of 70.1% and an RSD of 12.0%. Sample extracts from fish exposed to MG were also analyzed.
KW - analytical methods
KW - determination
KW - drug residues
KW - food contamination
KW - liquid chromatography
KW - malachite green
KW - mass spectrometry
KW - salmon
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - analytical techniques
KW - food contaminants
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053204716&site=ehost-live&scope=site
UR - email: sherri.turnipseed@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid extraction of aflatoxin from creamy and crunchy peanut butter.
AU - Vega, V. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 5
SP - 1383
EP - 1386
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Vega, V. A.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 8th St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20053218058. Publication Type: Journal Article. Language: English. Subject Subsets: Postharvest Research; Medical & Veterinary Mycology
N2 - A rapid extraction technique was developed for the isolation and subsequent liquid chromatographic determination of aflatoxins B1, B2, G1, and G2 in creamy and crunchy peanut butter. Peanut butter samples were extracted with a methanol 15% sodium chloride (7+3) solution followed by a second extraction with methanol. The extract was subjected to a cleanup using a Vicam Aflatesta® immunoaffinity column. Control samples for both smooth and crunchy peanut butter were fortified at 4 different levels for aflatoxin B1, B2, G1, and G2. The average aflatoxin B1, B2, G1, and G2 recoveries from smooth peanut butter were 95.2, 89.9, 94.1, and 62.4%, respectively, and 92.4, 84.3, 85.5, and 53.7%, respectively, from crunchy peanut butter. This extraction method and the official AOAC Method 991.31 produced comparable results for peanut butter samples. This method provides a rapid, specific, and easily controlled assay for the analysis of aflatoxins in peanut butter with minimal solvent usage. Organic solvent consumption was decreased by 85% and hazardous waste production was decreased by 80% in comparison with the AOAC method. Along with the decreased solvent consumption, significant savings in time were observed.
KW - aflatoxins
KW - analytical methods
KW - extraction
KW - food contamination
KW - groundnut butter
KW - groundnuts
KW - mycotoxins
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - aflatoxin B1
KW - aflatoxin B2
KW - aflatoxin G1
KW - aflatoxin G2
KW - analytical techniques
KW - food contaminants
KW - fungal toxins
KW - peanut butter
KW - peanuts
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053218058&site=ehost-live&scope=site
UR - email: vvega@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sample sizes needed for Specified Margins of Relative Error in the Estimates of the Repeatability and Reproducibility Standard Deviations.
AU - McClure, F. D.
AU - Lee, J. K.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 5
SP - 1503
EP - 1510
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - McClure, F. D.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053218060. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition
N2 - Sample size formulas are developed to estimate the repeatability and reproducibility standard deviations (sr and sR) such that the actual error in (sr and sR) relative to their respective true values, σr and σR, are at predefined levels. The statistical consequences associated with AOAC INTERNATIONAL required sample size to validate an analytical method are discussed. In addition, formulas to estimate the uncertainties of (sr and sR) were derived and are provided as supporting documentation.
KW - analytical methods
KW - estimation
KW - repeatability
KW - standard deviation
KW - analytical techniques
KW - sample size
KW - Human Nutrition (General) (VV100)
KW - Mathematics and Statistics (ZZ100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053218060&site=ehost-live&scope=site
UR - email: foster.mcclure@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ion chromatographic determination of nitrate and nitrite in vegetable and fruit baby foods.
AU - McMullen, S. E.
AU - Casanova, J. A.
AU - Gross, L. K.
AU - Schenck, F. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005///
VL - 88
IS - 6
SP - 1793
EP - 1796
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - McMullen, S. E.: Southeast Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth St NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20063014405. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 14797-55-8. Subject Subsets: Human Nutrition
N2 - An ion chromatographic method was developed for the determination of nitrate and nitrite in vegetable and fruit baby foods. The introduction of nitrate or nitrite to food may be natural or artificial as a preservative. Because of the higher pH found in babies' stomachs, nitrate can act as a reservoir for the production of nitrite by nitrate-reducing bacteria that can be harbored in the intestinal tract. This problem does not exist in adults because of the lower pH of the adult stomach. Exposure to nitrite by infants can result in methemoglobinemia (blue baby syndrome). There are also indications that carcinogenic nitrosamines can be formed from nitrates at the higher pH. These gastric conditions disappear at approximately 6 months of age. In this method, nitrate and nitrite were separated on a hydroxide-selective anion exchange column using online electrolytically generated high-purity hydroxide eluant and detected using suppressed conductivity detection. Average recoveries of spiked nitrite residue ranged from 91 to 104% and spiked nitrate residue ranged from 87 to 104%. This method and the AOAC Official Method yield comparable results for samples containing incurred nitrate residue. In addition, this method eliminates the hazardous waste associated with the use of cadmium found in the AOAC Official Method.
KW - analytical methods
KW - determination
KW - food contamination
KW - fruit
KW - infant foods
KW - ion exchange chromatography
KW - nitrate
KW - nitrite
KW - vegetables
KW - analytical techniques
KW - baby foods
KW - food contaminants
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063014405&site=ehost-live&scope=site
UR - email: smcmulle@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total mercury in seafood by cold vapor-atomic absorption spectroscopy (CVAAS) after microwave decomposition.
AU - Hight, S. C.
AU - Cheng, J.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2005///
VL - 91
IS - 3
SP - 557
EP - 570
CY - Oxford; UK
PB - Elsevier
SN - 0308-8146
AD - Hight, S. C.: Elemental Research Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20053032196. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7439-97-6. Subject Subsets: Human Nutrition
N2 - A method was developed for determination of total Hg in seafood using 10% w/v SnCl2 . 2H2O and continuous flow CVAAS after microwave decomposition in closed vessels. Seafoods were decomposed with 5 mL HNO3 and 1 mL 1% w/v NaCl at 200°C, transferred to polypropylene tubes containing 3.5 mL HCl, and diluted to 50 mL with H2O. Standards were prepared in diluent containing 10% v/v HNO3, 7% v/v HCl, and 0.02% w/v NaCl. Potential interference by 22 elements was evaluated. Interference by Se and Au was observed. Stability of standard solutions in HNO3, HCl and NaCl was evaluated. Stabilizing effect of chloride was demonstrated. Results for six reference materials containing 0.0371-1.59 mg/kg Hg were 86-106% of certificate values. Concentrations in 11 varieties of seafood were 0.015-1.78 mg/kg. Average recoveries of inorganic and organic Hg added to seafood were 102% and 99%, respectively; average recoveries from fortified method blanks were 100% and 97%, respectively. The limits of quantitation were 0.0022 and 0.011 mg/kg in seafoods and reference materials, respectively.
KW - analytical methods
KW - atomic absorption spectroscopy
KW - food contamination
KW - heavy metals
KW - mercury
KW - seafoods
KW - analytical techniques
KW - food contaminants
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053032196&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03088146
UR - email: susan.hight@fda.gov\john.cheng@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutagenicity of comfrey (Symphytum officinale) in rat liver.
AU - Mei, N.
AU - Guo, L.
AU - Fu, P. P.
AU - Heflich, R. H.
AU - Chen, T.
JO - British Journal of Cancer
JF - British Journal of Cancer
Y1 - 2005///
VL - 92
IS - 5
SP - 873
EP - 875
CY - Basingstoke; UK
PB - Nature Publishing Group
SN - 0007-0920
AD - Mei, N.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053055616. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Aromatic & Medicinal Plants; Agricultural Biotechnology
N2 - Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumourigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant.
KW - animal models
KW - carcinogens
KW - genetically engineered organisms
KW - genotoxicity
KW - liver
KW - medicinal plants
KW - mutagenesis
KW - mutagenicity
KW - mutagens
KW - pyrrolizidine alkaloids
KW - toxic substances
KW - transgenic animals
KW - rats
KW - Symphytum officinale
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Symphytum
KW - Boraginaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Boraginales
KW - drug plants
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - medicinal herbs
KW - officinal plants
KW - poisons
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053055616&site=ehost-live&scope=site
UR - http://www.bjcancer.com
UR - email: tchen@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of clinical characteristics between astrovirus and rotavirus infections diagnosed in 1997 to 2002 in Hungary.
AU - Jakab, F.
AU - Péterfai, J.
AU - Meleg, E.
AU - Bányai, K.
AU - Mitchell, D. K.
AU - Szucs, G.
JO - Acta Paediatrica
JF - Acta Paediatrica
Y1 - 2005///
VL - 94
IS - 6
SP - 667
EP - 671
CY - Basingstoke; UK
PB - Taylor & Francis
SN - 0803-5253
AD - Jakab, F.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7., Pécs, H-7623, Hungary.
N1 - Accession Number: 20053107707. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Aim: To compare the severity and clinical characteristics of human astrovirus (HAstV) infection with those of rotavirus infection among hospitalized children. Methods: Retrospective, case-control study (1997-2002) of astrovirus-infected and rotavirus-infected children from Hungary. Astroviruses were detected in faecal samples by enzyme immunoassay and/or reverse transcriptase-polymerase chain reaction. All faecal samples were tested for rotavirus and bacterial pathogens, and all negative samples were further tested for human astrovirus. Children with astrovirus-positive faecal samples and complete clinical data were included in this study. Results: Astrovirus was detected in 29 (1.8%) children, and 63 rotavirus-infected children were included as controls. Astrovirus-infected children had shorter duration of diarrhoea than rotavirus-infected children (median, 4 vs. 6 days; P<0.05), and 79% of the astrovirus infections were associated with a shorter duration of vomiting (median, one vs. 4 days; P<0.0001). Rotavirus-infected children had longer hospitalization (P<0.050) than astrovirus-infected children. Conclusion: The symptoms of HAstV and rotavirus infections are similar, but differ in terms of duration.
KW - children
KW - clinical aspects
KW - diarrhoea
KW - disease course
KW - human diseases
KW - human faeces
KW - symptoms
KW - viral diseases
KW - Hungary
KW - Astroviridae
KW - man
KW - Rotavirus
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Astrovirus
KW - clinical picture
KW - diarrhea
KW - disease progression
KW - human feces
KW - scouring
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053107707&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=101945
UR - email: jakabf@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health plan liability and ERISA: the expanding scope of state legislation.
AU - Hellinger, F. J.
AU - Young, G. J.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 2
SP - 217
EP - 223
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Hellinger, F. J.: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Room 5319, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20053188682. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Public Health
N2 - The federal Employee Retirement Income Security Act of 1974 (ERISA) supersedes state laws as they relate to employer-based health care plans. Thus, cases brought under ERISA are heard in federal courts. We examined the intent, scope, and impact of recent laws passed in 10 states attempting to expand the legal rights of health plan enrollees to sue their plans. In June 2004, the US Supreme Court ruled that state-law causes of action brought under the Texas Health Care Liability Act involving coverage decisions by Aetna Health Inc and CIGNA Health Care of Texas were preempted by ERISA. The full implications of this decision are not evident at present.
KW - health insurance
KW - labour economics
KW - labour relations
KW - law
KW - legislation
KW - personnel
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - economics of labor
KW - economics of labour
KW - employees
KW - labor economics
KW - labor relations
KW - legal aspects
KW - legal principles
KW - staff
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Health Economics (EE118) (New March 2000)
KW - Labour and Employment (EE900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053188682&site=ehost-live&scope=site
UR - email: fhelling@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Integrating occupational safety and health information into vocational and technical education and other workforce preparation programs.
AU - Schulte, P. A.
AU - Stephenson, C. M.
AU - Okun, A. H.
AU - Palassis, J.
AU - Biddle, E.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 3
SP - 404
EP - 411
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS-C14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053188708. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - The high rates of injury among young workers are a pressing public health issue, especially given the demand of the job market for new workers. Young and new workers experience the highest rates of occupational injuries of any age group. Incorporating occupational safety and health (OSH) information into the more than 20 000 vocational and other workforce preparation programs in the United States might provide a mechanism for reducing work-related injuries and illnesses among young and new workers. We assessed the status of including OSH information or training in workforce preparation programs and found there is an inconsistent emphasis on OSH information.
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - occupational health
KW - personnel
KW - safety at work
KW - technical training
KW - trauma
KW - vocational training
KW - working conditions
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - occupational safety
KW - staff
KW - traumas
KW - United States of America
KW - vocational education
KW - Labour and Employment (EE900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053188708&site=ehost-live&scope=site
UR - email: pas4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating the safety of new vaccines: summary of a workshop.
AU - Ellenberg, S. S.
AU - Foulkes, M. A.
AU - Midthun, K.
AU - Goldenthal, K. L.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 5
SP - 800
EP - 807
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Ellenberg, S. S.: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053088550. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Public concerns about the safety of vaccines arise on a regular basis. In November 2000, a workshop titled "Evaluation of New Vaccines: How Much Safety Data?" was convened by US Public Health Service agencies, including the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the Health Resources and Services Administration, to discuss appropriate methods for evaluating the safety of new vaccines. Workshop presentations addressed the current standards and approaches for new vaccine evaluation and postlicensure surveillance, as well as public views about vaccine safety and alternative approaches that could be considered. The advantages and disadvantages of conducting large controlled trials before licensure or widespread use of a new vaccine were discussed. This paper summarizes these presentations and discussions.
KW - adverse effects
KW - human diseases
KW - immunization
KW - public health
KW - reviews
KW - safety
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053088550&site=ehost-live&scope=site
UR - email: sellenbe@cceb.upenn.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diabetes outcomes in the Indian Health System during the era of the special diabetes program for Indians and the government performance and results act.
AU - Wilson, C.
AU - Gilliland, S.
AU - Cullen, T.
AU - Moore, K.
AU - Roubideaux, Y.
AU - Valdez, L.
AU - Vanderwagen, W.
AU - Acton, K.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 9
SP - 1518
EP - 1522
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Wilson, C.: Phoenix Indian Medical Center, Indian Health Service, 4212 N 16th St, Phoenix, AZ 85016, USA.
N1 - Accession Number: 20053174684. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 57-88-5, 9062-63-9. Subject Subsets: Public Health
N2 - Objectives: We reviewed changes in blood glucose, blood pressure, and cholesterol levels among American Indians and Alaska Natives between 1995 and 2001 to estimate the quality of diabetes care in the Indian Health Service (IHS) health care delivery system (USA). Methods: We conducted a cross-sectional analysis of data from the Indian Health Service Diabetes Care and Outcomes Audit. Results: Adjusted mean haemoglobin A1c (HbA1c) levels (7.9% vs 8.9%) and mean diastolic blood pressure levels (76 vs 79 mm Hg) were lower in 2001 than in 1995, respectively. A similar pattern was observed for mean total cholesterol (193 vs 208 mg/dL) and triglyceride (235 vs 257 mg/dL) levels in 2001 and 1995, respectively. Conclusions: We identified changes in intermediate clinical outcomes over the period from 1995 to 2001 that may reflect the global impact of increased resource allocation and improvements in processes on the quality of diabetes care, and we describe the results that may be achieved when community, health program, and congressional initiatives focus on common goals.
KW - American indians
KW - blood pressure
KW - cholesterol
KW - diabetes mellitus
KW - ethnic groups
KW - ethnicity
KW - haemoglobin A1
KW - health care
KW - health services
KW - human diseases
KW - Inuit
KW - triacylglycerols
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Eskimos
KW - ethnic differences
KW - health programmes
KW - hemoglobin A1
KW - triglycerides
KW - United States of America
KW - Health Services (UU350)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053174684&site=ehost-live&scope=site
UR - email: charlton.wilson@ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Racial/ethnic disparities in potentially preventable readmissions: the case of diabetes.
AU - Jiang, H. J.
AU - Andrews, R.
AU - Stryer, D.
AU - Friedman, B.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 9
SP - 1561
EP - 1567
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Jiang, H. J.: Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20053174691. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - Objectives: Considerable differences in prevalence of diabetes and management of the disease exist among racial/ethnic groups. We examined the relationship between race/ethnicity and hospital readmissions for diabetes-related conditions. Methods: Nonmaternal adult patients with Medicare, Medicaid, or private insurance coverage hospitalized for diabetes-related conditions in 5 states were identified from the 1999 State Inpatient Databases of the Healthcare Cost and Utilization Project (USA). Racial/ethnic differences in the likelihood of readmission were estimated by logistic regression with adjustment for patient demographic, clinical, and socioeconomic characteristics and hospital attributes. Results: The risk-adjusted likelihood of 180-day readmission was significantly lower for non-Hispanic Whites than for Hispanics across all 3 payers or for non-Hispanic Blacks among Medicare enrollees. Within each payer, Hispanics from low-income communities had the highest risk of readmission. Among Medicare beneficiaries, Blacks and Hispanics had higher percentages of readmission for acute complications and microvascular disease, while Whites had higher percentages of readmission for macrovascular conditions. Conclusions: Racial/ethnic disparities are more evident in 180-day than in 30-day readmission rates, and greatest among the Medicare population. Readmission diagnoses vary by race/ethnicity, with Blacks and Hispanics at higher risk for those complications more likely preventable with effective postdischarge care.
KW - blacks
KW - complications
KW - diabetes mellitus
KW - disease course
KW - ethnic groups
KW - ethnicity
KW - health care
KW - Hispanics
KW - human diseases
KW - relapse
KW - risk
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caucasians
KW - disease progression
KW - ethnic differences
KW - recurrence of disease
KW - relapses
KW - Demography (UU200)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053174691&site=ehost-live&scope=site
UR - email: jjiang@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Behavioral health problems, ex-offender reentry policies, and the "Second Chance Act".
AU - Pogorzelski, W.
AU - Wolff, N.
AU - Pan, K. Y.
AU - Blitz, C. L.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 10
SP - 1718
EP - 1724
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Pogorzelski, W.: Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ 08901, USA.
N1 - Accession Number: 20053207605. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - The federal "Second Chance Act of 2005" calls for expanding reentry services for people leaving prison, yet existing policies restrict access to needed services for those with criminal records. We examined the interaction between individual-level characteristics and policy-level restrictions related to criminal conviction, and the likely effects on access to resources upon reentry, using a sample of prisoners with Axis I mental disorders (n=3073). We identified multiple challenges related to convictions, including restricted access to housing, public assistance, and other resources. Invisible punishments embedded within existing policies were inconsistent with the call for second chances. Without modification of federal and state policies, the ability of reentry services to foster behavioral health and community reintegration is limited.
KW - access
KW - correctional institutions
KW - health care
KW - health policy
KW - health services
KW - mental disorders
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - mental illness
KW - psychiatric disorders
KW - Policy and Planning (EE120)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053207605&site=ehost-live&scope=site
UR - email: wpogorzelski@ifh.rutgers.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gender-specific behavioral health and community release patterns among New Jersey prison inmates: implications for treatment and community reentry.
AU - Blitz, C. L.
AU - Wolff, N.
AU - Pan, K. Y.
AU - Pogorzelski, W.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005///
VL - 95
IS - 10
SP - 1741
EP - 1746
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Blitz, C. L.: Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ 08901, USA.
N1 - Accession Number: 20053207609. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - Objectives. We describe behavioral health diagnoses and community release patterns among adult male and female inmates in New Jersey prisons and assess their implications for correctional health care and community reentry. Methods. We used clinical and classification data on a census of "special needs" inmates (those with behavioral health disorders) in New Jersey (n=3189) and a census of all special needs inmates released to New Jersey communities over a 12-month period (n=974). Results. Virtually all adult inmates with special needs had at least 1 Axis I mental disorder, and 68% of these had at least 1 additional Axis I mental disorder, a personality disorder, or addiction problem (67% of all male and 75% of all female special needs inmates). Of those special needs inmates released, 25% returned to the most disadvantaged counties in New Jersey (27% of all male and 18% of all female special needs inmates). Conclusions. Two types of clustering were found: gender-specific clustering of disorders among inmates and spatial clustering of ex-offenders in impoverished communities. These findings suggest a need for gendered treatment strategies within correctional settings and need for successful reentry strategies.
KW - behaviour
KW - communities
KW - correctional institutions
KW - diagnosis
KW - health care
KW - health services
KW - human diseases
KW - mental disorders
KW - prisoners
KW - New Jersey
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - mental illness
KW - psychiatric disorders
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053207609&site=ehost-live&scope=site
UR - email: cblitz@ifh.rutgers.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human papillomavirus type 16 E2 and E6/E7 variants.
AU - Swan, D. C.
AU - Rajeevan, M.
AU - Tortolero-Luna, G.
AU - Follen, M.
AU - Tucker, R. A.
AU - Unger, E. R.
JO - Gynecologic Oncology
JF - Gynecologic Oncology
Y1 - 2005///
VL - 96
IS - 3
SP - 695
EP - 700
CY - Orlando; USA
PB - Academic Press
SN - 0090-8258
AD - Swan, D. C.: U.S. Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA.
N1 - Accession Number: 20053051387. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Objectives: Polymorphisms in human papillomavirus (HPV) type 16 have been shown to be related to geographic areas and are broadly classified as European (E), African (Af), Asian (As), or Asian-American (AA). Certain variants have been reported as being more likely to cause cervical disease; our objectives were to identify new HPV16 polymorphisms, to determine the linkage of the E2 and E6/E7 regions and to determine the minimum sequence necessary to classify variants. Methods: We sequenced the complete E2, E6, and E7 regions in all HPV16-positive cervical samples identified in a case-control study of pre-invasive cervical disease. Results: In the 100 samples analyzed, only one new polymorphism was identified, a synonymous change, T3205A, in region E2. The frequency distribution of variants in the sample set was 37 European prototypes and 27 E-G350, 16 AA, 5 Af1, 2 Af2, 8 E-C109G, 3 E-G131G, and 2 As. As shown by others, region E7 varied much less than E6 and E2. Conclusions: In each case, E2 changes were linked to the expected E6/E7 changes, and there was no evidence for recombination. The linkage between E2 and E6/E7 allows variant classification to be based on a short E6 sequence (nt 109-350).
KW - cervix
KW - genetic polymorphism
KW - human diseases
KW - nucleotide sequences
KW - viral diseases
KW - human papillomavirus 16
KW - man
KW - Papillomavirus
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - Human papillomavirus
KW - Papovaviridae
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053051387&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG6-4F29SKY-6&_user=10&_handle=V-WA-A-W-ZV-MsSAYWA-UUW-U-AAAVZZEUBE-AAAWWVEYBE-AWWCDBEB-ZV-U&_fmt=summary&_coverDate=03%2F01%2F2005&_rdoc=19&_orig=browse&_srch=%23toc%236814%232005%23999039996%23572503!&_cdi=6814&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1a1fd509224f24fe44f6f6469d4faf4b
UR - email: dswan@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Moulds and yeasts in fresh and minimally processed vegetables, and sprouts.
AU - Tournas, V. H.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2005///
VL - 99
IS - 1
SP - 71
EP - 77
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Tournas, V. H.: Division of Natural Products, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053049131. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Medical & Veterinary Mycology; Human Nutrition; Public Health; Plant Pathology
N2 - A limited survey of fresh and minimally processed vegetables, and sprouts was conducted in the Washington, DC area to determine if potentially toxigenic and pathogenic fungi were present in these commodities. Thirty-nine ready-to-eat salads, 29 whole fresh vegetables and 116 sprout samples (bean, alfalfa, broccoli, crunchy, garlic, spicy, onion, clover, lentil and multi-seed sprouts) were purchased from 13 local supermarkets and tested for yeast and mould counts as well as the presence of toxigenic moulds. Yeasts were the most prevalent organisms found in these samples, at levels ranging from less than 100 to 4.0×108 cfu/g. Mould counts generally ranged from less than 100 to 4.0×104 cfu/g. Two crunchy sprout samples, however, contained unusually high numbers of Penicillium (1.1×108 and 1.3×108 cfu/g), two alfalfa sprout samples contained Geotrichum populations about 106 cfu/g, and two alfalfa sprout samples had Cladosporium counts higher than 2.5×105 cfu/g. The most common moulds found in fresh and minimally processed vegetables were Cladosporium, Alternaria and Penicillium; less common was Geotrichum. The most frequently isolated moulds from sprouts were Alternaria, Cladosporium, Penicillium, and Phoma. Phoma was especially common in alfalfa sprouts. Fusarium, Rhizopus, Mucor, and Geotrichum were isolated less often.
KW - broccoli
KW - clovers
KW - food contamination
KW - garlic
KW - human diseases
KW - lentils
KW - lucerne
KW - moulds
KW - onions
KW - sprouts
KW - surveys
KW - toxicity
KW - vegetables
KW - yeasts
KW - District of Columbia
KW - USA
KW - Allium
KW - Allium cepa
KW - Allium sativum
KW - Alternaria
KW - Brassica oleracea
KW - Brassica oleracea var. italica
KW - Cladosporium
KW - Fusarium
KW - Geotrichum
KW - Lens culinaris
KW - man
KW - Medicago
KW - Medicago sativa
KW - Mucor
KW - Mucoraceae
KW - Penicillium
KW - Phoma
KW - Rhizopus
KW - fungi
KW - eukaryotes
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Allium
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - Brassica oleracea
KW - Davidiellaceae
KW - Capnodiales
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Dipodascaceae
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Lens
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Medicago
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alfalfa
KW - calabrese
KW - Capparales
KW - Coelomycetes
KW - food contaminants
KW - fungus
KW - Hyphomycetes
KW - molds
KW - United States of America
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053049131&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01681605
UR - email: vtournas@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tetrachlorodibenzo-p-dioxin in baby food made from chicken produced before and after the termination of ball clay use in chicken feed in the United States.
AU - Hayward, D. G.
AU - Bolger, P. M.
JO - Environmental Research
JF - Environmental Research
Y1 - 2005///
VL - 99
IS - 3
SP - 307
EP - 313
CY - Orlando; USA
PB - Academic Press
SN - 0013-9351
AD - Hayward, D. G.: US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20053221415. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Poultry; Human Nutrition
N2 - Polychlorodibenzo-p-dioxin/furans were determined in chicken-containing baby foods collected from an annually conducted total diet survey by the US FDA during the last half of fiscal year (FY) 1997 through the first half of FY 1998. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was found in 8 of 11 baby food samples. The levels were between 0.025 and 0.28 ng kg-1 wet wt (0.25-5 ng kg-1 lipid). The mean TCDD value for chicken-containing baby food with "nondetects" equal to 0 was 1.2 ng kg-1 lipid, eight times higher than the average level found during a previous survey of chicken lipid TCDD levels in 1996. All other 2,3,7,8-chlorine-substituted dibenzo-p-dioxin congeners were also found with a profile consistent with the use of ball clay in chicken feed. TCDD was not detected in any FY 2000 baby foods made with chicken, with an average limit of detection (LOD) of 0.025 ng kg-1 wet wt. Whole eggs collected in 1997 from producers that never used ball clay in feed revealed TCDD measurements that were nearly all nondetects and none above the median LOD of 0.015 ng kg-1 wet wt. The percentage of chickens fed ball clay in their feed was estimated to be between 2.6% and 3.5% of all chickens produced in the United States in 1997.
KW - chicken meat
KW - eggs
KW - food contamination
KW - food safety
KW - fowl feeding
KW - infant foods
KW - polychlorinated dibenzodioxins
KW - poultry
KW - toxic substances
KW - USA
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - poisons
KW - United States of America
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053221415&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4F3FDW5-3&_user=3891418&_handle=V-WA-A-W-AE-MsSAYVW-UUW-U-AABYZUUWVW-AABZAYAUVW-CZVZYEAEA-AE-U&_fmt=full&_coverDate=11%2F30%2F2005&_rdoc=4&_orig=browse&_srch=%23toc%236774%232005%23999009996%23611617!&_cdi=6774&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=f4d9fd4f02d8c8c33dad320b42a5a6a0
UR - email: dhayward@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial susceptibility patterns of competitive exclusion bacteria applied to newly hatched chickens.
AU - Wagner, R. D.
AU - Cerniglia, C. E.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2005///
VL - 102
IS - 3
SP - 349
EP - 353
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Wagner, R. D.: Microbiology Division, HFT-250, FDA National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20053157450. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 114-07-8, 60-54-8, 64-75-5, 1401-69-0, 1404-90-6, 1404-93-9. Subject Subsets: Animal Nutrition; Human Nutrition; Poultry
N2 - Competitive exclusion (CE) products are mixtures of obligate and facultative anaerobic bacteria applied to poultry hatchlings for prevention of Salmonella colonization. These mixtures have the potential to introduce bacteria with undesirable antimicrobial drug resistance traits into the human food supply. Antimicrobial drug susceptibilities of 27 obligate and facultative anaerobes isolated from a commercial CE product were evaluated with a microdilution minimal inhibitory concentration (MIC) assay. Bacteroides distasonis and Bacteroides fragilis isolates were resistant to tetracycline and other antimicrobial drugs. An Escherichia coli isolate was resistant to four antimicrobial drugs: erythromycin, penicillin, vancomycin, and tylosin. Erythromycin-resistant enterococci and vancomycin-resistant Lactococcus lactis isolates in the CE product were detected. These findings suggest that more work needs to be done to assess the potential effects of CE product use in poultry on the food supply.
KW - antibacterial agents
KW - drug resistance
KW - erythromycin
KW - food safety
KW - penicillins
KW - poultry
KW - poultry products
KW - tetracycline
KW - tylosin
KW - vancomycin
KW - Bacteroides
KW - Bacteroides fragilis
KW - Enterococcus
KW - Escherichia coli
KW - fowls
KW - Lactococcus lactis
KW - Parabacteroides distasonis
KW - Bacteroidaceae
KW - Bacteroidales
KW - Bacteroidetes (class)
KW - Bacteroidetes (phylum)
KW - Bacteria
KW - prokaryotes
KW - Bacteroides
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Lactococcus
KW - Streptococcaceae
KW - Parabacteroides
KW - Porphyromonadaceae
KW - achromycin
KW - bacterium
KW - Bacteroides distasonis
KW - chickens
KW - competitive exclusion products
KW - domesticated birds
KW - E. coli
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Additives (RR130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053157450&site=ehost-live&scope=site
UR - email: dwagner@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mould and yeast flora in fresh berries, grapes and citrus fruits.
AU - Tournas, V. H.
AU - Katsoudas, E.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2005///
VL - 105
IS - 1
SP - 11
EP - 17
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063088896. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology; Human Nutrition
N2 - Fresh fruits are prone to fungal contamination in the field, during harvest, transport, marketing, and with the consumer. It is important to identify fungal contaminants in fresh fruits because some moulds can grow and produce mycotoxins on these commodities while certain yeasts and moulds can cause infections or allergies. In this study, 251 fresh fruit samples including several varieties of grapes, strawberries, blueberries, raspberries, blackberries, and various citrus fruits were surface-disinfected, incubated at room temperature for up to 14 days without supplemental media, and subsequently examined for mould and yeast growth. The level of contamination (percent of contaminated items/sample) varied depending on the type of fruit. All raspberry and blackberry samples were contaminated at levels ranging from 33% to 100%, whereas 95% of the blueberry samples supported mould growth at levels between 10% and 100% of the tested berries, and 97% of strawberry samples showed fungal growth on 33-100% of tested berries. The most common moulds isolated from these commodities were Botrytis cinerea, Rhizopus (in strawberries), Alternaria, Penicillium, Cladosporium and Fusarium followed by yeasts, Trichoderma and Aureobasidium. Thirty-five percent of the grape samples tested were contaminated and supported fungal growth; the levels of contamination ranged from 9% to 80%. The most common fungi spoiling grapes were Alternaria, B. cinerea and Cladosporium. Eighty-three percent of the citrus fruit samples showed fungal growth at levels ranging from 25% to 100% of tested fruits. The most common fungi in citrus fruits were Alternaria, Cladosporium, Penicillium, Fusarium and yeasts. Less common were Trichoderma, Geotrichum and Rhizopus.
KW - blackberries
KW - blueberries
KW - citrus fruits
KW - food contamination
KW - fruits
KW - grapes
KW - microbial contamination
KW - moulds
KW - raspberries
KW - strawberries
KW - yeasts
KW - Alternaria
KW - Aureobasidium
KW - Botrytis cinerea
KW - Cladosporium
KW - Fragaria
KW - Fusarium
KW - Geotrichum
KW - Mucoraceae
KW - Penicillium
KW - Rhizopus
KW - Rubus
KW - Rubus fruticosus
KW - Trichoderma
KW - Vaccinium
KW - Vitidaceae
KW - Vitis
KW - fungi
KW - eukaryotes
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - Dothioraceae
KW - Dothideales
KW - Botrytis
KW - Sclerotiniaceae
KW - Helotiales
KW - Leotiomycetes
KW - Davidiellaceae
KW - Capnodiales
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Dipodascaceae
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Rubus
KW - Hypocreaceae
KW - Ericaceae
KW - Ericales
KW - Rhamnales
KW - Vitidaceae
KW - brambles
KW - food contaminants
KW - fungus
KW - Hyphomycetes
KW - molds
KW - Vitaceae
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063088896&site=ehost-live&scope=site
UR - email: vtournas@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Respiratory morbidity in office workers in a water-damaged building.
AU - Cox-Ganser, J. M.
AU - White, S. K.
AU - Jones, R.
AU - Hilsbos, K.
AU - Storey, E.
AU - Enright, P. L.
AU - Rao, C. Y.
AU - Kreiss, K.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005///
VL - 113
IS - 4
SP - 485
EP - 490
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Cox-Ganser, J. M.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Suite H-2800, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20053068307. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 7732-18-5. Subject Subsets: Public Health
N2 - We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern USA. An initial questionnaire had 67% participation (888/1327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, lifetime asthma, and current asthma, 3.3 for adult-onset asthma, and 3.4 for symptoms improving away from work (P<0.05). Two-thirds (66/103) of the adult-onset asthma arose after occupancy, with an incidence rate of 1.9/1000 person-years before building occupancy and 14.5/1000 person-years after building occupancy. We conducted a 2nd survey on 140 respiratory cases, 63 subjects with fewer symptoms, and 44 comparison subjects. Health-related quality of life decreased with increasing severity of respiratory symptoms and in those with work-related symptoms. Symptom status was not associated with job satisfaction or how often jobs required hard work. Respiratory health problems accounted for one-third of sick leave, and respiratory cases with work-related symptoms had more respiratory sick days than those without work-related symptoms (9.4 vs. 2.4 days/year; P<0.01). Abnormal lung function and/or breathing medication use was found in 67% of respiratory cases, in 38% of participants with fewer symptoms, and in 11% of the comparison group (P<0.01), with similar results in never-smokers. Postoccupancy-onset asthma was associated with less atopy than preoccupancy-onset asthma. Occupancy of the water-damaged building was associated with onset and exacerbation of respiratory conditions, confirmed by objective medical tests. The morbidity and lost work time burdened both employees and employers.
KW - asthma
KW - atopy
KW - buildings
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - lung function
KW - morbidity
KW - occupational disorders
KW - occupational hazards
KW - occupational health
KW - office workers
KW - quality of life
KW - respiratory diseases
KW - respiratory system
KW - water
KW - USA
KW - West Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - lung diseases
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053068307&site=ehost-live&scope=site
UR - email: jjc8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gliomas and farm pesticide exposure in women: the Upper Midwest Health Study.
AU - Carreón, T.
AU - Butler, M. A.
AU - Ruder, A. M.
AU - Waters, M. A.
AU - Davis-King, K. E.
AU - Calvert, G. M.
AU - Schulte, P. A.
AU - Connally, B.
AU - Ward, E. M.
AU - Sanderson, W. T.
AU - Heineman, E. F.
AU - Mandel, J. S.
AU - Morton, R. F.
AU - Reding, D. J.
AU - Rosenman, K. D.
AU - Talaska, G.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005///
VL - 113
IS - 5
SP - 546
EP - 551
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Carreón, T.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia, Parkway, Mailstop R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053086511. Publication Type: Journal Article. Corporate Author: USA, Brain Cancer Collaborative Study Group Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - An excess incidence of brain cancer in male farmers has been noted in several studies, but few studies have focused on women. The National Institute for Occupational Safety and Health Upper Midwest Health Study evaluated effects of rural exposures for 341 female glioma cases and 528 controls, all adult (18-80 years of age) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. On average, controls lived longer on farms than did cases. After adjusting for age, age group, education, and farm residence, no association with glioma was observed for exposure to arsenicals, benzoic acids, carbamates, chloroacetanilides, dinitroanilines, inorganics, organochlorines, organophosphates, phenoxys, triazines, or urea-based or estrogenic pesticides. An increased risk of glioma was observed for carbamate herbicides but was not statistically significant (odds ratio=3.0; 95% confidence interval, 0.9-9.5). No association was observed between glioma and exposure to 12 widely used specific pesticides, after adjustment for age, age group, education, and any other pesticide exposure. These results were not affected after exclusion of proxy respondents (43% of cases, 2% of controls). Women were less likely than men to have applied pesticides, but more likely to have laundered pesticide-contaminated clothes. Storing pesticides in the house was associated with a statistically non-significant increased risk. Results show that exposure to pesticides was not associated with an increased risk of intracranial gliomas in women. Other farm-related factors could be etiologic factors and will be discussed in future reports.
KW - brain
KW - brain diseases
KW - exposure
KW - glioma
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - pesticides
KW - women
KW - Iowa
KW - Michigan
KW - Minnesota
KW - USA
KW - Wisconsin
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - brain disorders
KW - cerebrum
KW - United States of America
KW - Women (UU500)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053086511&site=ehost-live&scope=site
UR - email: carreota@ucmail.uc.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Time course of gene expression of inflammatory mediators in rat lung after diesel exhaust particle exposure.
AU - Rao, K. M. K.
AU - Ma, J. Y. C.
AU - Meighan, T.
AU - Barger, M. W.
AU - Pack, D.
AU - Vallyathan, V.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005///
VL - 113
IS - 5
SP - 612
EP - 617
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Rao, K. M. K.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20053086522. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 10102-43-9.
N2 - Diesel exhaust particles (DEPs) at three concentrations (5, 35, and 50 mg/kg body weight) were instilled into rats intratracheally. We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in lung tissue. Using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), we measured the mRNA levels of eight genes [interleukin (IL)-1β, IL-6, IL-10, iNOS (inducible nitric oxide synthase), MCP-1 (monocyte chemoattractant protein-1), MIP-2 (macrophage inflammatory protein-2), TGF-β1 (transforming growth factor-β1), and TNF-α (tumor necrosis factor-α)] in BAL cells and four genes [IL-6, ICAM-1 (intercellular adhesion molecule-1), GM-CSF (granulocyte/macrophage-colony stimulating factor), and RANTES (regulated upon activation normal T cell expressed and secreted)] in lung tissue. In BAL cells on day 1, high-dose exposure induced a significant up-regulation of IL-1β, iNOS, MCP-1, and MIP-2 but no change in IL-6, IL-10, TGF-β1, and TNF-α mRNA levels. There was no change in the mRNA levels of IL-6, RANTES, ICAM-1, and GM-CSF in lung tissue. Nitric oxide production and levels of MCP-1 and MIP-2 were increased in the 24-hr culture media of alveolar macrophages (AMs) obtained on day 1. IL-6, MCP-1, and MIP-2 levels were also elevated in the BAL fluid. BAL fluid also showed increases in albumin and lactate dehydrogenase. The cellular content in BAL fluid increased at all doses and at all time periods, mainly due to an increase in polymorphonuclear leukocytes. In vitro studies in AMs and cultured lung fibroblasts showed that lung fibroblasts are a significant source of IL-6 and MCP-1 in the lung.
KW - animal models
KW - chemokines
KW - diesel engines
KW - exposure
KW - inflammation
KW - laboratory animals
KW - lungs
KW - molecular biology
KW - molecular genetics
KW - nitric oxide
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053086522&site=ehost-live&scope=site
UR - email: mir8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays.
AU - Gwinn, M. R.
AU - Whipkey, D. L.
AU - Tennant, L. B.
AU - Weston, A.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005///
VL - 113
IS - 8
SP - 1046
EP - 1051
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Gwinn, M. R.: Pathology and Physiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20053153256. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-49-2, 121-75-5, 9039-53-6, 63231-63-0. Subject Subsets: Dairy Science; Public Health; Medical & Veterinary Entomology
N2 - Organophosphate pesticides are a major source of occupational exposure in the United States. Moreover, malathion has been sprayed over major urban populations in an effort to control mosquitoes carrying West Nile virus. Previous research, reviewed by the U.S. Environmental Protection Agency, on the genotoxicity and carcinogenicity of malathion has been inconclusive, although malathion is a known endocrine disruptor. Here, interindividual variations and commonality of gene expression signatures have been studied in normal human mammary epithelial cells from four women undergoing reduction mammoplasty. The cell strains were obtained from the discarded tissues through the Cooperative Human Tissue Network (sponsors: National Cancer Institute and National Disease Research Interchange). Interindividual variation of gene expression patterns in response to malathion was observed in various clustering patterns for the four cell strains. Further clustering identified three genes with increased expression after treatment in all four cell strains. These genes were two aldo-keto reductases (AKR1C1 and AKR1C2) and an estrogen-responsive gene (EBBP). Decreased expression of six RNA species was seen at various time points in all cell strains analyzed: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1), and a gene of unknown function (GenBank accession no. AI859865). Expression changes in all these genes, detected by DNA microarrays, have been verified by real-time polymerase chain reaction. Differential changes in expression of these genes may yield biomarkers that provide insight into interindividual variation in malathion toxicity.
KW - breast
KW - centromeres
KW - DNA
KW - epithelium
KW - exposure
KW - gene expression
KW - malathion
KW - mammary glands
KW - organophosphate insecticides
KW - plasminogen activator
KW - replication
KW - RNA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breasts
KW - deoxyribonucleic acid
KW - ribonucleic acid
KW - urokinase
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053153256&site=ehost-live&scope=site
UR - email: agw8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse events after inactivated influenza vaccination among children less than 2 years of age: analysis of reports from the Vaccine Adverse Event Reporting System, 1990-2003.
AU - McMahon, A. W.
AU - Iskander, J.
AU - Haber, P.
AU - Chang, S.
AU - Woo, E. J.
AU - Braun, M. M.
AU - Ball, R.
JO - Pediatrics
JF - Pediatrics
Y1 - 2005///
VL - 115
IS - 2(1 OF 2)
SP - 453
EP - 460
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - McMahon, A. W.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20053046751. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health
N2 - Background: In April 2002, the Advisory Committee on Immunization Practices (ACIP), in the USA, encouraged providers to vaccinate healthy 6- to 23-month-old infants and children with trivalent influenza vaccine (TIV). Objectives. To describe adverse events (AEs) reported to the Vaccine Adverse Event Reporting System (VAERS) after TIV vaccination among children <2 years of age and to compare reports before the ACIP guideline (January 1990 to June 2002) and after the ACIP guideline (July 2002 to June 2003). Methods: VAERS is a passive vaccine safety surveillance system begun by the Food and Drug Administration and the Centers for Disease Control and Prevention in 1990. We reviewed reports to VAERS for children <2 years of age who received TIV, alone or in combination with other vaccines. Influenza seasons were defined as the period from July 1 of one year to June 30 of the following year. Results: Between 1990 and 2003, VAERS received 166 TIV reports for children <2 years of age. There were 62 reports (37%) after administration of TIV alone and 104 reports (63%) after administration of TIV and ≥1 other vaccine. Approximately one third of reports (N=61) were in the post-ACIP guideline period. The 4 most frequent AE coding terms were fever (N=59, 35%), unspecified or urticarial rash (42, 25%), seizure (28, 17%), and injection site reaction (28, 17%). The median number of days from vaccination to symptom onset, the percentage of reports that represented serious AEs, and the gender distribution were similar in the pre-ACIP guideline and post-ACIP guideline periods. The percentage of reports describing an underlying medical condition for the subject decreased from 58% before the ACIP guideline to 37% after the ACIP guideline. Nineteen of 28 seizure reports (68%) described fever with the seizure within 2 days after vaccination. Seizure was the most frequent coding term (N=10, 7 with fever) among 23 serious reports. The annual number of TIV-related VAERS reports for children <2 years of age increased in the post-ACIP guideline period, probably at least in part because of an increase in the number of vaccinees after the ACIP announcement. The safety profiles in the pre-ACIP guideline and post-ACIP guideline periods were similar. Conclusions: In October 2003, the ACIP recommended that all healthy children 6 to 23 months of age be vaccinated with TIV, starting in the 2004-05 influenza season. This study provides generally reassuring, although limited, data regarding the safety of TIV among children in this age range. Continued surveillance for seizures and other clinically significant AEs is warranted and will continue.
KW - adverse effects
KW - children
KW - fever
KW - human diseases
KW - immune response
KW - immunization
KW - inactivated vaccines
KW - influenza
KW - influenza viruses
KW - surveys
KW - urticaria
KW - vaccination
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - flu
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Influenzavirus
KW - killed vaccines
KW - nettle rash
KW - pyrexia
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053046751&site=ehost-live&scope=site
UR - http://ecommerce.aap.org
UR - email: mcmahon@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacterial 16S ribosomal DNA in house dust mite cultures.
AU - Valerio, C. R.
AU - Murray, P.
AU - Arlian, L. G.
AU - Slater, J. E.
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2005///
VL - 116
IS - 6
SP - 1296
EP - 1300
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0091-6749
AD - Valerio, C. R.: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20852, USA.
N1 - Accession Number: 20063006236. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2 - Background: Allergen extracts prepared from Dermatophagoides farinae contain significantly more endotoxin than Dermatophagoides pteronyssinus extracts, and extracts from both mite extracts contain more endotoxin than pollen extracts. Attempts to culture bacteria from mite cultures have failed to establish the sources of the endotoxin. Objective: To determine the bacterial sources of endotoxin in mite extracts. Methods: Live mites of both species were obtained from 2 sources, DNA was extracted from the mites, and DNA encoding bacterial 16S ribosomal RNA was amplified by using specific primers. The amount of bacterial DNA in each mite DNA sample was determined by quantitative PCR using an internal standard, and sequence homologies were determined from amplifications performed by using a high-fidelity DNA polymerase. Results: DNA from D. farinae appeared to contain between 11-fold and 24-fold more 16S ribosomal gene copies than the genomic DNA from D. pteronyssinus (P<or=.003). Sequence analysis indicated the dominant presence of at least 3 phylogenetic clusters of Bartonella species (henselae, quintana, vinsonii, and grahamii), as well as uncharacterized α-proteobacteria, from both D. farinae and D. pteronyssinus. In a few clones, sequences from Escherichia coli, Pseudomonas species, and Acinetobacter species were also identified. Conclusion: House dust mite DNA contains evidence of Bartonella and other Gram-negative species. These Gram-negative species are likely to be the sources of the endotoxin found in mite allergenic extracts.
KW - allergens
KW - arthropod allergies
KW - endotoxins
KW - genomics
KW - house dust
KW - house dust mites
KW - lipopolysaccharides
KW - molecular biology
KW - molecular genetics
KW - ribosomal DNA
KW - Acinetobacter
KW - Bartonella
KW - Bartonella grahamii
KW - Bartonella henselae
KW - Bartonella quintana
KW - Bartonella vinsonii
KW - Dermatophagoides farinae
KW - Dermatophagoides pteronyssinus
KW - Escherichia coli
KW - mites
KW - Pseudomonas
KW - Moraxellaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Bartonella
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Pseudomonadaceae
KW - bacterium
KW - biochemical genetics
KW - E. coli
KW - house dust mite
KW - house-dust mites
KW - housedust mites
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063006236&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00916749
UR - email: slaterj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of renal service provision in south and mid Wales.
AU - Christie, S.
AU - Morgan, G.
AU - Heaven, M.
AU - Sandifer, Q.
AU - Woerden, H. van
JO - Public Health
JF - Public Health
Y1 - 2005///
VL - 119
IS - 8
SP - 738
EP - 742
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Christie, S.: National Public Health Service for Wales, Mamhilad Park Estate, Pontypool, Wales NP4 0YP, UK.
N1 - Accession Number: 20053117608. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - Objectives: This paper estimates point prevalence of renal replacement therapy (RRT) utilization within population strata defined by geography and deprivation in south and mid Wales. It investigates spatial accessibility of main and satellite renal units by comparing population and patient numbers within bands of travel time. Study design: Prevalence study based on patient registers. Methods: From a list of patient and renal unit locations, geocoded at the level of unit postcodes, and electoral division-level denominator population data, we calculated RRT point prevalence for the 16 unitary authorities in the study area, fifths of small area deprivation, and three bands of travel time from the nearest main renal unit and any (main or satellite) unit. Results: Overall point prevalence was 633 per million population (pmp) and this varied from 256 to 780 pmp across unitary authorities. RRT prevalence was lower in more deprived areas. Sixty-nine percent of the population and 73% of patients lived within 30 min of a main renal unit. Eighty-four percent of the population and 88% of patients lived within 30 min of a main or satellite renal unit. Conclusions: The provision of satellite renal units has significantly improved spatial accessibility of RRT services. However, a substantial proportion of the population remains geographically distant from renal units. This has important implications for planning of future provision of RRT, given the inverse relationship between RRT acceptance and travel time, and the impact on quality of life of patients who travel frequently to renal units.
KW - epidemiology
KW - health services
KW - human diseases
KW - kidney diseases
KW - kidneys
KW - medical treatment
KW - surgical operations
KW - transplantation
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - United Kingdom
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053117608&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: stephen.christie@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bone densitometry: the influence of deprivation on access to care.
AU - Griffiths, S.
AU - Fone, D.
AU - Borg, A.
JO - Public Health
JF - Public Health
Y1 - 2005///
VL - 119
IS - 10
SP - 870
EP - 874
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Griffiths, S.: National Public Health Service for Wales, 36, Orchard Street, Swansea SAI 5AQ, UK.
N1 - Accession Number: 20053183321. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - This is a general-practice-based ecological study to assess equity of access to the North Gwent bone densitometry service of the Gwent Healthcare National Health Service Trust, Wales, UK. The study population was the 540 women aged 50 years and over who were referred to the bone densitometry service for dual energy x-ray absorptiometry (DEXA) scan in 2001. Women were nearly twice as likely to be referred for a DEXA scan from the practice group with the least deprived population compared with the practice group with the most deprived population. Women were over 7 times more likely to be referred by general practitioner (GP) from the least deprived practices and one and a half times more likely to be referred by consultants from the most deprived practices. Of the 519 (96%) referrals with a femoral neck T-score recorded, 114 (22.0%) were defined as osteoporosis and 271 (52.2%) were defined as osteopenia. There was no difference in the proportions of women referred with either osteoporosis or osteopenia between the 3 practice deprivation groups (most deprived 75%, middle 74% and least deprived 73%), or between referrals from GPs and consultants (GPs 77.6%, consultants 71.3%, difference in proportions 6.3%, 95% CI 1.2%, 13.8%).
KW - access
KW - analytical methods
KW - bones
KW - densitometry
KW - deprivation
KW - health care
KW - health services
KW - human diseases
KW - osteopenia
KW - osteoporosis
KW - socioeconomic status
KW - women
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - analytical techniques
KW - Britain
KW - United Kingdom
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053183321&site=ehost-live&scope=site
UR - email: foned@cf.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The relationship between blood lead levels and neurobehavioral test performance in NHANES III and related occupational studies.
AU - Krieg, E. F., Jr.
AU - Chrislip, D. W.
AU - Crespo, C. J.
AU - Brightwell, W. S.
AU - Ehrenberg, R. L.
AU - Otto, D. A.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005///
VL - 120
IS - 3
SP - 240
EP - 251
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Krieg, E. F., Jr.: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Pkwy., MS C-22, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053198480. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - Objectives. The goals of this study were two-fold: (1) to assess the relationship between blood lead levels and neurobehavioral test performance in a nationally representative sample of adults from the third National Health and Nutrition Evaluation Survey and (2) to analyze the results from previously published studies of occupational lead exposure that used the same neurobehavioral tests as those included in the survey. Methods. Regression models were used to test and estimate the relationships between measurements of blood lead and performance on a simple reaction time, a symbol-digit substitution, and a serial digit learning test in adults aged 20-59 years who participated the survey. Mixed models were used to analyze the data from the occupational studies. Results. The blood lead levels of those participating in the survey ranged from 0.7 to 41.8 µg/dl. The estimated geometric mean was 2.51 µg/dl, and the estimated arithmetic mean was 3.30 µg/dl. In the survey, no statistically significant relationships were found between blood lead concentration and performance on the three neurobehavioral tests when adjusted for covariates. In the occupational studies, the groups exposed to lead consistently performed worse than control groups on the simple reaction time and digit-symbol substitution tests. Conclusions. The results from the survey and the occupational studies do not provide evidence for impairment of neurobehavioral test performance at levels below 25 µg/dl, the concentration that the Centers for Disease Control and Prevention define as elevated in adults. The average blood lead level of the exposed groups in the occupational studies was 41.07 µg/dl, less than 50 µg/dl, the minimum concentration that the Occupational Safety and Health Administration requires for medical removal from the workplace. Given the evidence of impaired neurobehavioral performance in these groups, the 50 µg/dl limit should be reevaluated.
KW - blood
KW - human diseases
KW - lead
KW - lead poisoning
KW - mental ability
KW - occupational hazards
KW - occupational health
KW - physiology
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - intelligence
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053198480&site=ehost-live&scope=site
UR - email: erk3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Injuries in child laborers in the informal sector in Mexico City, Mexico, 1997.
AU - Baron, S. L.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005///
VL - 120
IS - 6
SP - 598
EP - 600
CY - Stuttgart; Germany
PB - S. Hirzel Verlag
SN - 0033-3549
AD - Baron, S. L.: Priority Populations and Health Disparities, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-13, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063001840. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Tropical Diseases; Rural Development; World Agriculture, Economics & Rural Sociology
N2 - A survey was conducted to determine work-related injuries among children employed in the informal sector in Mexico City, Mexico, during February-March 1997. A questionnaire collecting data on the cause and nature of the injury was administered to the child or parent of an injured child. 584 injured children (420 boys and 164 girls; aged 5-17 years) were surveyed. Of them, 69 (12%) were injured while working. The proportion of injuries associated with work was higher for males and increased with age. The most frequent types of work-related injuries were traumatic injuries (39%), including sprains, strains and fractures, and deep lacerations (38%). Work-related injuries were more severe than non-work-related injuries, with physicians reporting no likely long-term sequelae in 73% of work-related injuries. There were 6 cases of amputations and 2 cases of paralysis among the work-related injuries. Based on occupation type, male construction workers and construction helpers had the most work-related injuries (38%), followed by workers in stores, markets and restaurants (23%). For female workers, most injuries occurred in workers in stores, markets and restaurants (50%). The most common causes of injuries were contact with equipment or objects (41%) and falls (19%). Violence was an important cause of injury among those working in streets (2 of 3 injuries). The average working hours of children working only was 56 h/week, and of those working and studying was 27 h/week. Their average incomes were 200 and 105 pesos, respectively. It is suggested that programmes promoting occupational safety for child labourers should be implemented.
KW - adolescents
KW - age
KW - aggressive behaviour
KW - amputation
KW - behaviour
KW - bone fractures
KW - boys
KW - child labour
KW - children
KW - falls
KW - girls
KW - income
KW - informal sector
KW - occupational hazards
KW - occupational health
KW - paralysis
KW - sex differences
KW - surveys
KW - trauma
KW - working hours
KW - wounds
KW - young workers
KW - Mexico
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - aggressive behavior
KW - behavior
KW - child labor
KW - sprains and strains
KW - teenagers
KW - traumas
KW - youth employment
KW - Labour and Employment (EE900)
KW - Conflict (UU495) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063001840&site=ehost-live&scope=site
UR - email: sbaron@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of poliovirus-specific IgA in saliva by ELISA tests.
AU - Ivanov, A.
AU - Dragunsky, E.
AU - Ivanova, O.
AU - Rezapkin, G.
AU - Potapova, S.
AU - Chumakov, K.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2005///
VL - 126
IS - 1/2
SP - 45
EP - 52
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Ivanov, A.: Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-470, NLRC/B-121, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20053092246. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - This study describes three ELISA methods for detection of immunoglobulin A (IgA) specific to three types of Sabin strains of poliovirus in saliva taken from 70 children aged 6-7 years vaccinated with a full course of oral poliovirus vaccine (OPV). Of the three ELISA methods (conventional IgA ELISA and two new methods described in this communication, the α-capture ELISA and Inhibition ELISA), α-capture ELISA demonstrated the highest sensitivity, with all saliva samples testing positive for Sabin poliovirus strains specific IgA antibodies of 1-3 types. Of 62 available α-capture ELISA positive saliva samples, all were also positive by the inhibition ELISA, and a significant correlation was found between the results. Fifty-two available saliva samples were screened by the three ELISA tests with positive results, and a significant correlation was found between the α-capture ELISA and the IgA ELISA; the correlation between the IgA ELISA and inhibition ELISA was not significant. The results of this study suggest that determination of Sabin poliovirus-specific IgA in human saliva by the ELISA techniques (especially by the novel α-capture ELISA) can be used reliably for evaluation of mucosal immunity in large groups of people immunized with poliovirus vaccines and for epidemiological studies.
KW - children
KW - ELISA
KW - human diseases
KW - IgA
KW - immunity
KW - immunization
KW - immunological techniques
KW - oral vaccination
KW - poliomyelitis
KW - saliva
KW - strains
KW - vaccines
KW - viral diseases
KW - Russia
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - enzyme linked immunosorbent assay
KW - human poliovirus
KW - immune sensitization
KW - mucosal immunity
KW - polio
KW - Russian Federation
KW - salivary secretions
KW - serological techniques
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053092246&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: ivanov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid approach to identify an unrecognized viral agent.
AU - Hu, Y.
AU - Hirshfield, I.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2005///
VL - 127
IS - 1
SP - 80
EP - 86
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Hu, Y.: U.S. Food and Drug Administration, Northeast Regional Laboratory, Microbiological Sciences Branch, 158-15 Liberty Avenue, Jamaica, NY 11433, USA.
N1 - Accession Number: 20053108213. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Public Health
N2 - For epidemic control, rapid identification and characterization of the responsible unknown agent are crucial. To address this critical question, a method was developed for virus discovery based on a flexible nested-PCR subtraction hybridization. As a positive control, we used hepatitis C virus as a hypothetical unrecognized virus and "discover" it in the sample. Using template-switching universal long-PCR to produce large quantities of cDNA, our nested-PCR-based subtractive hybridization coupled with a single-strand deletion technology removed most of the common cDNA. Following subtraction hybridization, a cDNA library was constructed and displayed by differential reverse dot blot hybridization. This new genomic subtraction hybridization method will be ideally suited to identify rapidly any previously unrecognized viral agent.
KW - complementary DNA
KW - messenger RNA
KW - molecular genetics
KW - polymerase chain reaction
KW - rapid methods
KW - hepatitis C virus
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - biochemical genetics
KW - cDNA
KW - mRNA
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053108213&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: yhu@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The incidence of respiratory symptoms and diseases among pulp mill workers with peak exposures to ozone and other irritant gases.
AU - Henneberger, P. K.
AU - Olin, A. C.
AU - Andersson, E.
AU - Hagberg, S.
AU - Torén, K.
JO - Chest
JF - Chest
Y1 - 2005///
VL - 128
IS - 4
SP - 3028
EP - 3037
CY - Northbrook; USA
PB - American College of Chest Physicians
SN - 0012-3692
AD - Henneberger, P. K.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-H2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063163224. Publication Type: Journal Article. Language: English. Registry Number: 10049-04-4, 10028-15-6, 7446-09-5. Subject Subsets: Public Health
N2 - Objectives: Pulp mills in Sweden started to use ozone as a bleaching agent in the early 1990s. The goal of this study was to investigate whether the incidence of selected respiratory outcomes was associated with peak exposures to ozone or other irritant gases (ie, chlorine dioxide [ClO2] or sulfur dioxide [SO2]) used in these mills. Methods: Bleachery workers (n=245) from three pulp mills where ozone was used participated in surveys in the mid- to late-1990s. Comparison workers (n=80) were from two adjacent paper mills. The person-time at risk was calculated for each participant, covering the period of employment when ozone was used. Data were collected by questionnaire, and a peak exposure was defined as a self-reported exposure to an irritant gas resulting in acute respiratory symptoms. The outcomes analyzed were self-reports of physician-diagnosed asthma, attacks of wheeze, and chronic bronchitis (ie, chronic cough with phlegm). Participants also reported when the peak exposures and outcomes occurred. Results: Based on proportional hazards regression (controlling for gender, age, cigarette smoking, atopy, and peak irritant exposures that occurred before follow-up), workers who reported both ozone and ClO2/SO2 peak exposures had elevated hazard ratios (HRs) for all three outcomes. Those who reported only ozone peak exposures had elevated HRs of 6.5 (95% confidence interval [CI], 1.2 to 36.3) for asthma and 3.3 (95% CI, 1.1 to 10.2) for attacks of wheeze but no increase in risk for chronic bronchitis. Workers with only ClO2/SO2 peak exposures had elevated HRs for attacks of wheeze (HR, 7.5; 95% CI, 1.9 to 29.3) and chronic bronchitis (HR, 22.9; 95% CI, 4.5 to 118.2) but not for asthma. Conclusions: These findings suggest the need for additional efforts to prevent peak exposures in pulp-bleaching operations.
KW - asthma
KW - bleaching agents
KW - bronchitis
KW - chlorine dioxide
KW - disease incidence
KW - epidemiology
KW - human diseases
KW - lungs
KW - occupational hazards
KW - occupational health
KW - ozone
KW - pulp mill workers
KW - respiratory diseases
KW - sulfur dioxide
KW - wheezing
KW - Sweden
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Scandinavia
KW - Northern Europe
KW - Europe
KW - lung diseases
KW - sulphur dioxide
KW - wheeze
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063163224&site=ehost-live&scope=site
UR - http://www.chestjournal.org/cgi/content/abstract/128/4/3028
UR - email: pkh0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of oxidation products of solanesol produced during air sampling for tobacco smoke by electrospray mass spectrometry and HPLC.
AU - Tucker, S. P.
AU - Pretty, J. R.
JO - Analyst
JF - Analyst
Y1 - 2005///
VL - 130
IS - 10
SP - 1414
EP - 1424
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 0003-2654
AD - Tucker, S. P.: National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053181429. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 10028-15-6. Subject Subsets: Public Health
N2 - Solanesol, a 45-carbon, trisesquiterpenoid alcohol found in tobacco leaves and tobacco smoke, has been used as a quantitative marker for tobacco smoke for years. However, solanesol appears to be unreliable as a quantitative marker for tobacco smoke during environmental air sampling because it can be degraded substantially when present as a component of tobacco smoke and by as much as 100% when present as pure solanesol on fortified filters during air sampling. Since there is strong evidence that ozone is the agent responsible for the degradation, solanesol appears to be unreliable as a quantitative marker during indoor air sampling when indoor levels of ozone are greater than about 15 ppb. The degree of loss of pure solanesol is directly proportional to the concentration of ozone and the length of the sampling period and depends on the type of 37 mm membrane filter used for air sampling (PTFE or quartz fibre). While the degree of loss of solanesol is inversely proportional to the relative humidity of the air at a sampling rate of 1.7 L min-1, the degree of loss is virtually independent of relative humidity at a lower sampling rate; i.e., 0.25 L min-1. A curve of loss of solanesol on a filter versus concentration of ozone from an ozone generator is virtually identical to a curve segment based on atmospheric ozone under the same conditions of air sampling. Oxidation of solanesol by ozone to approximately 25 to 60% completion produces at least three series of products for a total of at least 26 compounds: (1) isoprenoid acetones, (2) ω-hydroxyisoprenoid acetaldehydes, and (3) isoprenoid oxoaldehydes. All products in each series were tentatively identified as their derivatives with 2-(p-aminophenyl)ethanol (APE) by electrospray mass spectrometry (ES-MS). Ten ozonation products were detected as their 2,4-dinitrophenylhydrazine derivatives by HPLC at 360 nm: 4-oxopentanal and nine isoprenoid acetones (acetone, 6-methyl-5-hepten-2-one, geranylacetone, farnesylacetone, tetraprenylacetone, geranylfarnesylacetone, farnesylfarnesylacetone, farnesylgeranylgeranylacetone and bombiprenone).
KW - air
KW - air pollutants
KW - air pollution
KW - oxidation
KW - ozone
KW - smoke
KW - tobacco
KW - tobacco smoking
KW - Nicotiana
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - atmospheric pollution
KW - isoprenoid acetones
KW - isoprenoid oxoaldehyde
KW - omega-hydroxyisoprenoid acetaldehyde
KW - solanesol
KW - Meteorology and Climate (PP500)
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053181429&site=ehost-live&scope=site
UR - http://www.rsc.org/analyst
UR - email: spt1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The seasonality of human campylobacter infection and Campylobacter isolates from fresh, retail chicken in Wales.
AU - Meldrum, R. J.
AU - Griffiths, J. K.
AU - Smith, R. M. M.
AU - Evans, M. R.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2005///
VL - 133
IS - 1
SP - 49
EP - 52
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Meldrum, R. J.: National Public Health Service for Wales, Llandough Hospital, Penarth, Cardiff, CF64 2XX, UK.
N1 - Accession Number: 20053026411. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Poultry; Public Health
N2 - Seasonal peaks in both human Campylobacter infections and poultry isolates have been observed in several European countries but remain unexplained. We compared weekly data on human Campylobacter infections with thermophilic Campylobacter isolation rates from fresh, retail poultry samples (n=514) purchased weekly in Wales, UK between January and December 2002. Human isolates (n=2631) peaked between weeks 22 and 25 (early June) and poultry isolates (n=364) between weeks 24 and 26 (late June). In the absence of a temporal association, we postulate that the seasonal rise in humans is not caused by a rise in isolation rates in poultry but that both are more likely to be associated with a common, but as yet unidentified, environmental source.
KW - bacterial diseases
KW - chicken meat
KW - human diseases
KW - poultry
KW - seasonality
KW - UK
KW - Wales
KW - Campylobacter
KW - fowls
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - chickens
KW - domesticated birds
KW - United Kingdom
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053026411&site=ehost-live&scope=site
UR - email: Richard.Meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for abdominal aortic aneurysm: recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2005///
VL - 142
IS - 3
SP - 198
EP - 202
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20053078511. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for abdominal aortic aneurysm and the supporting scientific evidence and updates the 1996 recommendations on this topic. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the evidence synthesis on this topic, which is available on the USPSTF Web site (http://www.preventiveservices.ahrq.gov).
KW - aneurysm
KW - human diseases
KW - screening
KW - vascular diseases
KW - vascular system
KW - abdominal aortic aneurysm
KW - blood vessel disorders
KW - screening tests
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053078511&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for HIV: recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2005///
VL - 143
IS - 1
SP - 32
EP - 37
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20053132692. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - This statement summarizes the US Preventive Services Task Force (USPSTF) recommendations on screening for HIV infection and the supporting scientific evidence, and updates the 1996 recommendations on this topic. The complete information on which this statement is based, including evidence tables and references, is included in the summaries of the evidence and evidence syntheses on this topic, available through the USPSTF Web site (http://www.preventiveservices.ahrq.gov). The recommendation is also posted on the Web site of the National Guideline Clearinghouse (http://www.guideline.gov).
KW - guidelines
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - screening
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - recommendations
KW - screening tests
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053132692&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2005///
VL - 143
IS - 5
SP - 355
EP - 361
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20053162726. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 58 ref. Subject Subsets: Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility, along with the supporting scientific evidence. The complete information on which this statement is based, including evidence tables and references, is included in the evidence synthesis available through the USPSTF Web site (www.preventiveservices.ahrq.gov). The recommendation is also posted on the Web site of the National Guideline Clearinghouse (www.guideline.gov).
KW - breast
KW - breast cancer
KW - genes
KW - guidelines
KW - human diseases
KW - mutations
KW - neoplasms
KW - ovarian cancer
KW - ovarian diseases
KW - ovaries
KW - risk
KW - risk assessment
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breasts
KW - cancers
KW - recommendations
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053162726&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Structure and distribution of the phosphoprotein phosphatase genes, prpA and prpB, among Shigella subgroups.
AU - Li, B. G.
AU - Brown, E. W.
AU - D'Agostino, C.
AU - LeClerc, J. E.
AU - Cebula, T. A.
JO - Microbiology (Reading)
JF - Microbiology (Reading)
Y1 - 2005///
VL - 151
IS - 8
SP - 2671
EP - 2683
CY - Reading; UK
PB - Society for General Microbiology
SN - 1350-0872
AD - Li, B. G.: Division of Molecular Biology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053141280. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9025-75-6. Subject Subsets: Tropical Diseases; Public Health
N2 - Phosphoprotein phosphatases encoded by the prpA and prpB genes function in signal transduction pathways for degradation of misfolded proteins in the extracytoplasmic compartments of Escherichia coli. In order to trace the evolution of prp genes and assess their roles in other enteric pathogens, the structure and distribution of these genes among closely related Shigella subgroups were studied. PCR amplification, probe hybridization studies and DNA sequencing were used to determine the prp genotypes of 58 strains from the four Shigella subgroups, Dysenteriae, Boydii, Sonnei and Flexneri. It was found that the prp alleles among Shigella subgroups were extremely susceptible to gene inactivation and that the mutations involved in prp allele inactivation were varied. They included IS insertions, gene replacement by an IS element, a small deletion within the gene or large deletion engulfing the entire gene region, and base substitutions that generated premature termination codons. As a result, of 58 strains studied, only eight (114%) possessed intact prpA and prpB genes. Of the Shigella strains examined, 76% (44/58) showed at least one of the prp alleles inactivated by one or more IS elements, including IS1, IS4, IS600 and IS629. Phylogenetic analysis revealed that IS elements have been independently acquired in multiple lineages of Shigella, suggesting that loss of functional alleles has been advantageous during Shigella strain evolution.
KW - alleles
KW - distribution
KW - genes
KW - phosphoprotein phosphatase
KW - phylogenetics
KW - strains
KW - Shigella boydii
KW - Shigella dysenteriae
KW - Shigella flexneri
KW - Shigella sonnei
KW - Shigella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053141280&site=ehost-live&scope=site
UR - email: tcebula@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of Cryptosporidium parvum genotype 2 in domestic horses.
AU - Chalmers, R. M.
AU - Thomas, A. L.
AU - Butler, B. A.
AU - Morel, M. C. G. D.
JO - Veterinary Record
JF - Veterinary Record
Y1 - 2005///
VL - 156
IS - 2
SP - 49
EP - 50
CY - London; UK
PB - British Veterinary Association
SN - 0042-4900
AD - Chalmers, R. M.: Cryptosporidium Reference Unit, National Public Health Service, Microbiology Swansea, Singleton Hospital, Swansea SA2 8QA, UK.
N1 - Accession Number: 20053005432. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Veterinary Science; Protozoology; Veterinary Science
N2 - Fifty-two faecal samples from horses and foals were obtained in Wales, UK, in May-June 2002. Samples were screened using an immunofluorescent monoclonal antibody technique and epifluorescence microscopy for the presence of Cryptosporidium spp. oocysts. Oocysts were detected by the immunofluorescent antibody test in 2 faecal samples, which was designated as C. parvum genotype 2 by polymerase chain reaction (PCR). Both samples were from foals aged under 8 weeks. The zoonotic potential of this organism is briefly discussed.
KW - cryptosporidiosis
KW - diagnosis
KW - disease prevalence
KW - disease surveys
KW - epidemiological surveys
KW - epidemiology
KW - foals
KW - horse dung
KW - immunofluorescence
KW - oocysts
KW - polymerase chain reaction
KW - zoonoses
KW - UK
KW - Wales
KW - Cryptosporidium parvum
KW - horses
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - disease surveillance
KW - fluorescent antibody technique
KW - IFAT
KW - PCR
KW - United Kingdom
KW - zoonotic infections
KW - Sport Animals (LL075) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053005432&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Significance of Cryptosporidium parvum in horses.
AU - Chalmers, R. M.
AU - Grinberg, A.
JO - Veterinary Record
JF - Veterinary Record
Y1 - 2005///
VL - 156
IS - 21
SP - 688
EP - 688
CY - London; UK
PB - British Veterinary Association
SN - 0042-4900
AD - Chalmers, R. M.: UK Cryptosporidium Reference Unit, National Public Health Service Microbiology Swansea, Singleton Hospital, Swansea SA2 8QA, UK.
N1 - Accession Number: 20053091453. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Veterinary Science; Veterinary Science; Protozoology
N2 - Cryptosporidium parvum has been confirmed using molecular methods in the Przewalski's horse and in domestic horses in both an outbreak of foal diarrhoea in New Zealand and a convenience sample survey of horses in West Wales in 2002. The authors of this paper clarify that the outbreak of severe foal diarrhoea in New Zealand clearly implicates C. parvum as a potentially important pathogen in immunologically normal and normoglobulinaemic equids. This is supported by the lack of detection of other gastrointestinal pathogens and the epizoological features and histopathological findings consistent with cryptosporidiosis. There is a need for progress in both public and animal health. To do this, all hosts need to be identified, the routes and risks of transmission of the parasite need to be elucidated and a better understanding of the parasite population genetics and molecular mechanisms of host adaptation are required.
KW - cryptosporidiosis
KW - disease transmission
KW - molecular genetics
KW - outbreaks
KW - risk assessment
KW - risk factors
KW - zoonoses
KW - New Zealand
KW - Cryptosporidium parvum
KW - horses
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - biochemical genetics
KW - zoonotic infections
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053091453&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Economic evaluation of the 7-vaccine routine childhood immunization schedule in the United States, 2001.
AU - Zhou, F. J.
AU - Santoli, J.
AU - Messonnier, M. L.
AU - Yusuf, H. R.
AU - Shefer, A.
AU - Chu, S. Y.
AU - Rodewald, L.
AU - Harpaz, R.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2005///
VL - 159
IS - 12
SP - 1136
EP - 1144
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Zhou, F. J.: National Immunization Program, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Rd NE, Mailstop E-52, Atlanta, GA 30333, USA.
N1 - Accession Number: 20063000371. Publication Type: Journal Article. Language: English. Number of References: 100 ref. Subject Subsets: Public Health
N2 - Objective: To evaluate the economic impact of the routine US childhood immunization schedule: diphtheria and tetanus toxoids and acellular pertussis; tetanus and diphtheria toxoids; Haemophilus influenzae type b conjugate; inactivated poliovirus; measles, mumps, and rubella; hepatitis B; and varicella vaccines. Design: Decision tree-based analysis was conducted using population-based vaccination coverage, published vaccine efficacies, historical data on disease incidence before vaccination, and disease incidence reported for 1995-2001. Costs were estimated using the direct cost and societal (direct and indirect costs) perspectives. Program costs included vaccine, administration, vaccine-associated adverse events, and parent travel and time lost. All costs were inflated to 2001 US dollars, and all costs and benefits in the future were discounted at a 3% annual rate. Participants: A hypothetical 2001 US birth cohort of 3 803 295 infants was followed up from birth through death. Main Outcome Measures: Net present value (net savings) and benefit-cost ratios of routine immunization. Results: Routine childhood immunization with the 7 vaccines was cost saving from the direct cost and societal perspectives, with net savings of $9.9 billion and $43.3 billion, respectively. Without routine vaccination, direct and societal costs of diphtheria, tetanus, pertussis, H. influenzae type b, poliomyelitis, measles, mumps, rubella, congenital rubella syndrome, hepatitis B, and varicella would be $12.3 billion and $46.6 billion, respectively. Direct and societal costs for the vaccination program were an estimated $2.3 billion and $2.8 billion, respectively. Direct and societal benefit-cost ratios for routine childhood vaccination were 5.3 and 16.5, respectively. Conclusion: Regardless of the perspective, the current routine childhood immunization schedule results in substantial cost savings.
KW - children
KW - cost analysis
KW - costs
KW - diphtheria
KW - diphtheria pertussis tetanus vaccines
KW - economic evaluation
KW - hepatitis B
KW - human diseases
KW - immunization
KW - measles
KW - mumps
KW - pertussis
KW - rubella
KW - tetanus
KW - vaccination
KW - vaccines
KW - varicella
KW - USA
KW - Bordetella pertussis
KW - Clostridium tetani
KW - Corynebacterium diphtheriae
KW - Haemophilus influenzae type b
KW - Hepatitis B virus
KW - Human herpesvirus 3
KW - man
KW - Measles virus
KW - Mumps virus
KW - Poliovirus
KW - Rubella virus
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Corynebacterium
KW - Corynebacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Haemophilus influenzae
KW - Haemophilus
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Rubulavirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - Rubivirus
KW - Togaviridae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chicken pox
KW - costing
KW - costings
KW - German measles
KW - Human poliovirus
KW - immune sensitization
KW - lockjaw
KW - United States of America
KW - varicella-zoster virus
KW - whooping cough
KW - Health Economics (EE118) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063000371&site=ehost-live&scope=site
UR - email: fazl@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectious disease hospitalizations among older adults in the United States from 1990 through 2002.
AU - Curns, A. T.
AU - Holman, R. C.
AU - Sejvar, J. J.
AU - Owings, M. F.
AU - Schonberger, L. B.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2005///
VL - 165
IS - 21
SP - 2514
EP - 2520
CY - Chicago; USA
PB - American Medical Association
SN - 0003-9926
AD - Curns, A. T.: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Rd, Mail Stop A-39, Atlanta, GA 30333, USA.
N1 - Accession Number: 20053215483. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Background: To understand conditions associated with substantial morbidity among older adults (aged 65 years), we describe hospitalization rates and trends for overall infectious disease (ID) and for specific ID groups among older adults in the United States from January 1, 1990, through December 31, 2002. Methods: The National Hospital Discharge Survey was used to generate hospitalization estimates from 1990 through 2002 for the US population of older adults. By using a comprehensive list of International Classification of Diseases, Ninth Revision, Clinical Modification codes associated with IDs, we identified and analyzed hospitalizations associated with specific ID and ID-related categories. Results: There were approximately 21.4 million (SE, 636 000) ID hospitalizations among older adults from 1990 through 2002, and between 1990 through 1992 and 2000 through 2002, the ID hospitalization rate increased 13% from 449.4 to 507.9 hospitalizations per 10 000 older adults (P=.01). This increase was caused in part by the increasing relative contributions of patients aged 75 through 84 years and 85 years or older to the older adult ID hospitalization rate. Almost half of ID hospitalizations (46% [SE, 0.7%]) and ID-related hospital deaths (48% [SE, 1.6%]) among older adults were associated with lower respiratory tract infections from 2000 through 2002. Conclusions: The hospitalization rate for IDs increased slightly among the older adult US population during the 13-year study and was associated with the aging of the older adult population. The reduction of ID hospitalization rates among older adults could help attenuate the anticipated increase in the number of hospitalizations among older adults and should be a high priority given the projected population growth among older adults in the United States.
KW - elderly
KW - epidemiology
KW - human diseases
KW - infectious diseases
KW - lower respiratory tract infections
KW - morbidity
KW - mortality
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - communicable diseases
KW - death rate
KW - elderly people
KW - hospitalization
KW - older adults
KW - senior citizens
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053215483&site=ehost-live&scope=site
UR - email: acurns@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anthrax lethal toxin induces endothelial barrier dysfunction.
AU - Warfel, J. M.
AU - Steele, A. D.
AU - D'Agnillo, F.
JO - American Journal of Pathology
JF - American Journal of Pathology
Y1 - 2005///
VL - 166
IS - 6
SP - 1871
EP - 1881
CY - Bethesda; USA
PB - American Society for Investigative Pathology, Inc
SN - 0002-9440
AD - Warfel, J. M.: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20053125006. Publication Type: Journal Article. Language: English. Registry Number: 9064-37-3. Subject Subsets: Public Health
N2 - Hemorrhage and pleural effusion are prominent pathological features of systemic anthrax infection. We examined the effect of anthrax lethal toxin (LT), a major virulence factor of Bacillus anthracis, on the barrier function of primary human lung microvascular endothelial cells. We also examined the distribution patterns of cytoskeletal actin and vascular endothelial-cadherin (VE-cadherin), both of which are involved in barrier function regulation. Endothelial monolayers cultured on porous membrane inserts were treated with the LT components lethal factor (LF) and protective antigen (PA) individually, or in combination. LT induced a concentration- and time-dependent decrease in transendothelial electrical resistance that correlated with increased permeability to fluorescently labeled albumin. LT also produced a marked increase in central actin stress fibers and significantly altered VE-cadherin distribution as revealed by immunofluorescence microscopy and cell surface enzyme-linked immunosorbent assay. Treatment with LF, PA, or the combination of an inactive LF mutant and PA did not alter barrier function or the distribution of actin or VE-cadherin. LT-induced barrier dysfunction was not dependent on endothelial apoptosis or necrosis. The present findings support a possible role for LT-induced barrier dysfunction in the vascular permeability changes accompanying systemic anthrax infection.
KW - actin
KW - albumins
KW - anthrax
KW - apoptosis
KW - bacterial diseases
KW - cytoskeleton
KW - endothelium
KW - human diseases
KW - lungs
KW - necrosis
KW - permeability
KW - protective antigens
KW - toxins
KW - virulence
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cadherins
KW - endothelial cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053125006&site=ehost-live&scope=site
UR - http://ajp.amjpathol.org/cgi/content/abstract/166/6/1871
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk of mortality with a bloodstream infection is higher in the less severely ill at admission.
AU - Kim, P. W.
AU - Perl, T. M.
AU - Keelaghan, E. F.
AU - Langenberg, P.
AU - Perencevich, E. N.
AU - Harris, A. D.
AU - Song, X. Y.
AU - Roghmann, M. C.
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
Y1 - 2005///
VL - 171
IS - 6
SP - 616
EP - 620
CY - New York; USA
PB - American Thoracic Society
SN - 0003-0805
AD - Kim, P. W.: Food and Drug Administration, Division of Anti-Infective Drug Products, Rockville, Pennsylvania, USA.
N1 - Accession Number: 20053072285. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Rationale: Health care-associated bloodstream infections are common in critically ill patients; however, investigators have had difficulty in quantifying the clinical impact of these infections given the high expected mortality among these patients. Objective: A study was conducted to estimate the impact of health care-associated bloodstream infections on in-hospital mortality after adjusting for severity of illness at critical care admission. Method: A cohort of medical and surgical intensive care unit patients were included in the study. Measurements: The severity of illness at admission, bloodstream infection, and in-hospital mortality. Main Results: Among 2783 adult patients, 269 developed unit-associated bloodstream infections. After adjusting for severity of illness, patients with a lower initial severity of illness who developed an infection, had a greater than 2-fold higher risk for in-hospital mortality (hazard ratio (HR)=2.42, 95% confidence interval (CI) 1.70, 3.44) when compared with patients without infection and with a similar initial severity of illness. In contrast, patients with a higher initial severity of illness who subsequently developed an infection did not have an increased risk for in-hospital mortality (HR=0.96, 95% CI 0.76, 1.23) when compared with patients without infection but with a similar initial severity of illness. Conclusions: It is suggested that these infections in less ill patients have a higher attributable impact on subsequent mortality than in more severely ill patients. Focusing interventions to prevent bloodstream infections in less severely ill patients would be expected to have a greater benefit in terms of mortality reduction.
KW - bacteraemia
KW - bacterial diseases
KW - human diseases
KW - mortality
KW - nosocomial infections
KW - risk assessment
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacteremia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - death rate
KW - hospital infections
KW - Human Health and the Environment (VV500)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053072285&site=ehost-live&scope=site
UR - email: mroghman@epi.umaryland.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells.
AU - Fang, H.
AU - Cordoba-Rodriguez, R.
AU - Lankford, C. S. R.
AU - Frucht, D. M.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2005///
VL - 174
IS - 8
SP - 4966
EP - 4971
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Fang, H.: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 29B, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053079478. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 102524-44-7, 85898-30-2. Subject Subsets: Public Health
N2 - Anthrax lethal toxin (LT) is a critical virulence factor that cleaves and inactivates MAPK kinases (MAPKKs) in host cells and has been proposed as a therapeutic target in the treatment of human anthrax infections. Despite the potential use of anti-toxin agents in humans, the standard activity assays for anthrax LT are currently based on cytotoxic actions of anthrax LT that are cell-, strain-, and species-specific, which have not been demonstrated to occur in human cells. We now report that T cell proliferation and IL-2 production inversely correlate with anthrax LT levels in human cell assays. The model CD4+ T cell tumor line, Jurkat, is a susceptible target for the specific protease action of anthrax LT. Anthrax LT cleaves and inactivates MAPKKs in Jurkat cells, whereas not affecting proximal or parallel TCR signal transduction pathways. Moreover, anthrax LT specifically inhibits PMA/ionomycin- and anti-CD3-induced IL-2 production in Jurkat cells. An inhibitor of the protease activity of anthrax LT completely restores IL-2 production by anthrax LT-treated Jurkat cells. Anthrax LT acts on primary CD4+ T cells as well, cleaving MAPKKs and leading to a 95% reduction in anti-CD3-induced proliferation and IL-2 production. These findings not only will be useful in the development of new human cell-based bioassays for the activity of anthrax LT, but they also suggest new mechanisms that facilitate immune evasion by Bacillus anthracis. Specifically, anthrax LT inhibits IL-2 production and proliferative responses in CD4+ T cells, thereby blocking functions that are pivotal in the regulation of immune responses.
KW - anthrax
KW - bacterial toxins
KW - CD4+ lymphocytes
KW - human diseases
KW - immune response
KW - interleukin 2
KW - virulence
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - CD4+ cells
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053079478&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: frucht@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9.
AU - Huang, L. Y.
AU - Ishii, K. J.
AU - Akira, S.
AU - Aliberti, J.
AU - Golding, B.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2005///
VL - 175
IS - 6
SP - 3964
EP - 3970
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Huang, L. Y.: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053171409. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Registry Number: 9007-49-2, 9008-11-1. Subject Subsets: Veterinary Science; Veterinary Science
N2 - In this report we provide evidence, for the first time, that bacterial DNA in the context of heat-killed Brucella abortus (HKBA) engages TLR9 in dendritic cells (DC), resulting in a Th1-like cytokine response. This is based on the findings that HKBA induction of IL-12p40 is: (1) abolished in DC from TLR9-/- mice; (2) blocked by suppressive oligodeoxynucleotides; (3) simulated by bacterial DNA derived from HKBA; and (4) abrogated by DNase or methylation of the DNA from HKBA. Furthermore, the effect of HKBA can be inhibited by chloroquine, indicating that endosomal acidification is required and supporting the notion that DNA from HKBA is interacting with TLR9 at the level of the endosome, as is the case with CpG oligodeoxynucleotides. In addition to DC, HKBA can elicit IL-12p40 secretion from macrophages, in which case the effect is wholly MyD88 dependent but only partially TLR9 dependent. This probably explains why HKBA effects in vivo are only partially reduced in TLR9-/-, but absent in MyD88-/- mice. Because of their intimate interactions with T cells, the DC response is most likely to be critical for linking innate and adaptive immune responses, whereas the macrophage reaction may play a role in enhancing NK cell and bystander immune responses. In addition to IL-12p40, HKBA induces other Th1-like cytokines, namely, IFN-α and IFN-γ, in a TLR9-dependent manner. These cytokines are important in protection against viruses and bacteria, and their induction enhances HKBA as a potential carrier for vaccines.
KW - animal models
KW - brucellosis
KW - DNA
KW - DNA methylation
KW - interferon
KW - interleukin 12
KW - laboratory animals
KW - T lymphocytes
KW - Brucella abortus
KW - mice
KW - Brucella
KW - Brucellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - deoxyribonucleic acid
KW - T cells
KW - undulant fever
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053171409&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: Golding@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Compromised B cell responses to influenza vaccination in HIV-infected individuals.
AU - Malaspina, A.
AU - Moir, S.
AU - Orsega, S. M.
AU - Vasquez, J.
AU - Miller, N. J.
AU - Donoghue, E. T.
AU - Kottilil, S.
AU - Gezmu, M.
AU - Follmann, D.
AU - Vodeiko, G. M.
AU - Levandowski, R. A.
AU - Mican, J. M.
AU - Fauci, A. S.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005///
VL - 191
IS - 9
SP - 1442
EP - 1450
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Malaspina, A.: Laboratory of Immunoregulation, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20053109245. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - Background. Yearly influenza vaccination, although recommended for human immunodeficiency virus (HIV)-infected individuals, has not received thorough evaluation in the era of antiretroviral therapy. We assessed the impact of HIV disease on B cell responses to influenza vaccination. Methods. Sixty-four HIV-infected and 17 HIV-negative individuals received the 2003-2004 trivalent inactivated influenza vaccine. Frequencies of influenza-specific antibody-secreting cells (ASCs) were measured by enzyme-linked immunospot (ELISPOT) assay, and antibody responses were measured by hemagglutination-inhibition (HI) assay. Memory responses to influenza were measured by ELISPOT assay after polyclonal activation of B cells in vitro. Results. Prevaccination HI titers were significantly higher in HIV-negative than in HIV-infected individuals. Peak HI titers and influenza-specific ASC frequencies were directly correlated with CD4+ T cell counts in HIV-infected individuals. Influenza-specific memory B cell responses were significantly lower in HIV-infected than in HIV-negative individuals and were directly correlated with CD4+ T cell counts. Conclusions. HIV infection is associated with a weak antibody response to influenza vaccination that is compounded by a poor memory B cell response. CD4+ T cell count is a critical determinant of responsiveness to influenza vaccination, and the contribution of plasma HIV RNA level is suggestive and warrants further investigation.
KW - B lymphocytes
KW - CD4+ lymphocytes
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunization
KW - inactivated vaccines
KW - influenza
KW - influenza viruses
KW - polyvalent vaccines
KW - T lymphocytes
KW - vaccination
KW - vaccines
KW - viral diseases
KW - Maryland
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - B cells
KW - CD4+ cells
KW - flu
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - Influenzavirus
KW - killed vaccines
KW - T cells
KW - T4 lymphocytes
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053109245&site=ehost-live&scope=site
UR - email: smoir@niaid.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of different vaccination schedules on excretion of oral poliovirus vaccine strains.
AU - Laassri, M.
AU - Lottenbach, K.
AU - Belshe, R.
AU - Wolff, M.
AU - Rennels, M.
AU - Plotkin, S.
AU - Chumakov, K.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005///
VL - 192
IS - 12
SP - 2092
EP - 2098
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Laassri, M.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, USA.
N1 - Accession Number: 20063017048. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health
N2 - Inactivated poliovirus vaccine (IPV) is believed to induce significantly lower mucosal immunity than oral poliovirus vaccine (OPV). Most of the data supporting this were generated before enhanced IPV (eIPV) was introduced. Excretion of poliovirus by OPV recipients can be used to assess intestinal immunity. We studied polymerase chain reaction amplification of viral complementary DNA from the stool of children vaccinated with either OPV alone or eIPV. Of first-time OPV recipients, 92% excreted virus after 1 week, and 81% excreted virus after 3 weeks. Prior vaccination with OPV reduced the number to 22% and shortened the duration of virus excretion (to 5% after 3 weeks). Two doses of IPV reduced the number of poliovirus-positive 1-week samples (to 76%), the duration of shedding (to 37% at 3 weeks), and the quantity of excreted virus. This suggests that IPV-vaccinated communities are partially protected from the spread of poliovirus. Further enhancement of IPV potency may lead to even higher levels of mucosal immunity.
KW - children
KW - human diseases
KW - immunity
KW - immunization
KW - inactivated vaccines
KW - poliomyelitis
KW - vaccination
KW - Maryland
KW - USA
KW - Human poliovirus 1
KW - Human poliovirus 2
KW - Human poliovirus 3
KW - man
KW - Poliovirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immune sensitization
KW - killed vaccines
KW - polio
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063017048&site=ehost-live&scope=site
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo.
AU - Cowley, S. C.
AU - Hamilton, E.
AU - Frelinger, J. A.
AU - Su, J.
AU - Forman, J.
AU - Elkins, K. L.
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
Y1 - 2005///
VL - 202
IS - 2
SP - 309
EP - 319
CY - New York; USA
PB - Rockefeller University Press
SN - 0022-1007
AD - Cowley, S. C.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20053139876. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4+ and CD8+ T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4-CD8-CD3+αβ+γδ-NK1.1- T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis or Francisella tularensis live vaccine strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tuberculosis or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4-CD8- T cells have a role in the control of intracellular infection and may contribute to successful vaccination.
KW - bacterial diseases
KW - CD4+ lymphocytes
KW - CD8+ lymphocytes
KW - disease models
KW - experimental infection
KW - human diseases
KW - immunity
KW - in vitro
KW - live vaccines
KW - macrophages
KW - mycobacterial diseases
KW - natural killer cells
KW - spleen
KW - strains
KW - survival
KW - T lymphocytes
KW - tuberculosis
KW - Francisella tularensis
KW - mice
KW - Mycobacterium tuberculosis
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - attenuated vaccines
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - CD3+ lymphocytes
KW - CD4+ cells
KW - CD8+ cells
KW - experimental transmission
KW - in vivo
KW - mycobacterial infections
KW - T cells
KW - T4 lymphocytes
KW - T8 lymphocytes
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053139876&site=ehost-live&scope=site
UR - http://www.jem.org/
UR - email: cowley@cber.fda.gov\elkins@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats.
AU - Doerge, D. R.
AU - Young, J. F.
AU - McDaniel, L. P.
AU - Twaddle, N. C.
AU - Churchwell, M. I.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2005///
VL - 208
IS - 3
SP - 199
EP - 209
CY - Orlando; USA
PB - Elsevier Inc
SN - 0041-008X
AD - Doerge, D. R.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053206352. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms, particularly toxicokinetics and bioavailability. This study compares the toxicokinetics of AA and its epoxide metabolite, glycidamide (GA), in serum and tissues of male and female F344 rats following acute exposure by intravenous, gavage, and dietary routes at 0.1 mg/kg AA or intravenous and gavage routes with an equimolar amount of GA. AA was rapidly absorbed after oral dosing, was widely distributed to tissues, was efficiently converted to GA, and produced increased levels of GA-DNA adducts in liver. GA was also rapidly absorbed, widely distributed to tissues, and produced increased liver DNA adduct levels. AA bioavailability after aqueous gavage was 60-98% and from the diet was 32-44%; however, first-pass metabolism or other kinetic change resulted in much higher internal exposures to GA (2- to 7-fold) when compared to the intravenous route. A similar effect on metabolism to GA following oral administration was previously observed under an identical exposure paradigm in mice. Furthermore, DNA adduct formation in rat liver showed the same proportionality with the respective GA AUC value as did mice in the previous study. These findings suggest that as the AA content in food is reduced, species-differences in GA formation and subsequent DNA adduct formation may be minimized. These findings provide additional information needed to assess genotoxic risks from the low levels of AA that are pervasive in the food supply.
KW - acrylamides
KW - animal models
KW - bioavailability
KW - DNA
KW - female animals
KW - food contamination
KW - genotoxicity
KW - laboratory animals
KW - liver
KW - male animals
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - food contaminants
KW - glycidamide
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053206352&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4G1GD2S-3&_user=3891418&_handle=V-WA-A-W-AW-MsSAYWA-UUA-U-AABCDZUEYU-AABBBVADYU-CUWEZDYEZ-AW-U&_fmt=full&_coverDate=11%2F01%2F2005&_rdoc=2&_orig=browse&_srch=%23toc%237159%232005%23997919996%23608399!&_cdi=7159&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=167cda27c9787992945ea841b2d21d83
UR - email: ddoerge@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protective effects of vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity.
AU - Yun JaeSuk
AU - Na HanKwang
AU - Park KiSook
AU - Lee YunHee
AU - Kim EunYeob
AU - Lee SungYong
AU - Kim JooIl
AU - Kang JuHee
AU - Kim DongSup
AU - Choi KiHwan
JO - Toxicology
JF - Toxicology
Y1 - 2005///
VL - 216
IS - 2/3
SP - 140
EP - 146
CY - Shannon; Irish Republic
PB - Elsevier Ireland
SN - 0300-483X
AD - Yun JaeSuk: Division of General Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyung-Gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20063013887. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 59-02-9, 51-61-6, 1406-18-4. Subject Subsets: Human Nutrition
N2 - The protective effect of an antioxidant, Vitamin E (DL-α-tocopherol, 100 mg/kg/day, 8 days p.o. in vivo and 10 and 50 µM in vitro) was tested against PCB-induced neurotoxicity. In vivo studies: Microdialysis was used to investigate changes in the striatal extracellular dopamine level and in p-nNOS expression in PCB-treated (Aroclor 1254, 10 µg/ml, 2 µl/min, 5 h; 6 µg was infused by microdialysis probe) rats. In vitro studies: Cell viability and levels of p-nNOS expression were observed in PCB-treated (Aroclor 1254, 5 µg/ml) immortalized dopaminergic cell line (CATH.a cells). Results: Treatment with PCB: (1) decreased the extracellular dopamine level in rat striatum, (2) increased p-nNOS expression both in rat striatal tissue and in CATH.a cells, (3) reduced and cell viability of, and (4) increased LDH release by CATH.a cells. However, Vitamin E showed a protective effect against PCB-induced toxicity and downregulation of the extracellular dopamine level. These results indicate that Vitamin E may have neuroprotective effects by inhibiting PCB-induced nNOS phosphorylation.
KW - alpha-tocopherol
KW - antioxidants
KW - brain
KW - dopamine
KW - in vitro
KW - laboratory animals
KW - neurons
KW - neurotoxicity
KW - polychlorinated biphenyls
KW - vitamin E
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - endocrine disruptors
KW - nerve cells
KW - neurones
KW - PCBs
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063013887&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4H57JX1-2&_user=3891418&_handle=V-WA-A-W-WU-MsSAYZA-UUW-U-AAVAVVYYUD-AABEUWEZUD-ZBUUWBWBC-WU-U&_fmt=full&_coverDate=12%2F15%2F2005&_rdoc=6&_orig=browse&_srch=%23toc%235175%232005%23997839997%23611942!&_cdi=5175&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=b6151199e4040ccce90c9bef397ea2c5
UR - email: hyokwa@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18.
AU - Golding, H.
AU - Khurana, S.
AU - Yarovinsky, F.
AU - King, L. R.
AU - Abdoulaeva, G.
AU - Antonsson, L.
AU - Owman, C.
AU - Platt, E. J.
AU - Kabat, D.
AU - Andersen, J. F.
AU - Sher, A.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005///
VL - 280
IS - 33
SP - 29570
EP - 29577
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Golding, H.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MA 20892, USA.
N1 - Accession Number: 20053172345. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Protozoology; Public Health
N2 - Molecular mimicry of chemokine ligands has been described for several pathogens. Toxoplasma gondii produces a protein, cyclophilin-18 (C-18), which binds to the human immunodeficiency virus (HIV) co-receptor CCR5 and inhibits fusion and infection of T cells and macrophages by R5 viruses but not by X4 viruses. We recently identified structural determinants of C-18 required for anti-HIV activity (Yarovinsky, F., Andersen, J. F., King, L. R., Caspar, P., Aliberti, J., Golding, H., and Sher, A. (2004) J. Biol. Chem. 279, 53635-53642). Here we have elucidated the fine specificity of CCR5 residues involved in binding and HIV inhibitory potential of C-18. To delineate the regions of CCR5 involved in C-18 binding, we analyzed C-18 inhibition of cells expressing CXCR4/CCR5 chimeric receptors and CCR5 with a truncated N terminus (Δ2-19). These experiments identified a critical role for the N terminus of CCR5 in C-18 binding and anti-HIV activity. Studies with a large panel of CCR5 N-terminal peptides, including Tyr-sulfated analogues, truncated peptides, and alanine-scanning mutants, suggested that each of the 12-17 amino acids in the N terminus of CCR5 are essential for C-18 binding and inhibitory activity. Tyr sulfation did not improve C-18 reactivity. This finding is of interest because the same CCR5 N-terminal region was shown previously to play a key role in binding of HIV-1 envelope glycoproteins. The elucidation of the functional C-18-binding mechanism may help in the rational design of novel antiviral agents against HIV.
KW - chemokines
KW - chimaeras
KW - envelope glycoproteins
KW - HIV infections
KW - HIV-1 infections
KW - human diseases
KW - human immunodeficiency viruses
KW - ligands
KW - macrophages
KW - mutants
KW - nucleoside analogues
KW - peptides
KW - protozoal infections
KW - T lymphocytes
KW - viral diseases
KW - Human immunodeficiency virus 1
KW - Toxoplasma gondii
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Toxoplasma
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - chimeras
KW - cyclophilin 18
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - human immunodeficiency virus type 1
KW - nucleoside analogs
KW - protozoal diseases
KW - T cells
KW - viral infections
KW - Non-food/Non-feed Animal Products (SS100)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053172345&site=ehost-live&scope=site
UR - email: goldingh@cber.FDA.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute illnesses associated with pesticide exposure at schools.
AU - Alarcon, W. A.
AU - Calvert, G. M.
AU - Blondell, J. M.
AU - Mehler, L. N.
AU - Sievert, J.
AU - Propeck, M.
AU - Tibbetts, D. S.
AU - Becker, A.
AU - Lackovic, M.
AU - Soileau, S. B.
AU - Das, R.
AU - Beckman, J.
AU - Male, D. P.
AU - Thomsen, C. L.
AU - Stanbury, M.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2005///
VL - 294
IS - 4
SP - 455
EP - 465
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Alarcon, W. A.: National Institute for Occupational Safety and Health, US Centers for Disease Control and Prevention, 4676 Columbia Pkwy, Mail Stop R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20053133293. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Agricultural Entomology
N2 - Context: Pesticides continue to be used on school property, and some schools are at risk of pesticide drift exposure from neighbouring farms, which leads to pesticide exposure among students and school employees. However, information on the magnitude of illnesses and risk factors associated with these pesticide exposures is not available. Objective: To estimate the magnitude of and associated risk factors for pesticide-related illnesses at schools. Design, Setting, and Participants: Analysis of surveillance data from 1998 to 2002 of 2593 persons with acute pesticide-related illnesses associated with exposure at schools. Nationwide information on pesticide-related illnesses is routinely collected by 3 national pesticide surveillance systems: the National Institute for Occupational Safety and Health's Sentinel Event Notification System for Occupational Risks pesticides program, the California Department of Pesticide Regulation, and the Toxic Exposure Surveillance System. Main Outcome Measures: Incidence rates and severity of acute pesticide-related illnesses. Results: Incidence rates for 1998-2002 were 7.4 cases per million children and 27.3 cases per million school employee full-time equivalents. The incidence rates among children increased significantly from 1998 to 2002. Illness of high severity was found in 3 cases (0.1%), moderate severity in 275 cases (11%), and low severity in 2315 cases (89%). Most illnesses were associated with insecticides (n=895, 35%), disinfectants (n=830, 32%), repellents (n=335, 13%), or herbicides (n=279, 11%). Among 406 cases with detailed information on the source of pesticide exposure, 281 (69%) were associated with pesticides used at schools and 125 (31%) were associated with pesticide drift exposure from farmland. Conclusions: Pesticide exposure at schools produces acute illnesses among school employees and students. To prevent pesticide-related illnesses at schools, implementation of integrated pest management programs in schools, practices to reduce pesticide drift, and adoption of pesticide spray buffer zones around schools are recommended.
KW - nontarget effects
KW - nontarget organisms
KW - pesticide residues
KW - risk assessment
KW - schools
KW - toxicity
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - non-target organisms
KW - non-target species
KW - nontarget species
KW - school buildings
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053133293&site=ehost-live&scope=site
UR - email: walarcon@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse events reported following live, cold-adapted, intranasal influenza vaccine.
AU - Izurieta, H. S.
AU - Haber, P.
AU - Wise, R. P.
AU - Iskander, J.
AU - Pratt, D.
AU - Mink, C.
AU - Chang, S.
AU - Braun, M. M.
AU - Ball, R.
JO - JAMA, Journal of the American Medical Association
JF - JAMA, Journal of the American Medical Association
Y1 - 2005///
VL - 294
IS - 21
SP - 2720
EP - 2725
CY - Chicago; USA
PB - American Medical Association
SN - 0098-7484
AD - Izurieta, H. S.: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Second Floor, Suite 200S, HFM-222, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20053217461. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Context: In June 2003, the US Food and Drug Administration licensed a trivalent live, attenuated influenza vaccine (LAIV-T) for intranasal administration to healthy persons 5 to 49 years of age. Although prelicensure testing involved 20 228 vaccinees, clinical trials were not of sufficient size to detect rare adverse events reliably. Objective: To identify adverse events reported following LAIV-T administration after licensure. Design, Setting, and Participants: All adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) during the 2003-2004 and the 2004-2005 influenza seasons. Main Outcome Measures: Numbers and proportions of reported adverse events and reporting rates of adverse events per 100 000 vaccinees. Results: Approximately 2 500 000 persons received LAIV-T during the first 2 postlicensure seasons. As of August 16, 2005, VAERS received 460 adverse event reports for vaccinations received from August 2003 through July 2005. No fatalities were reported. There were 7 reports of possible anaphylaxis, 2 reports of Guillain-Barré syndrome, 1 report of Bell palsy, and 8 reports of asthma exacerbation among individuals with a prior asthma history. Events in individuals for whom the vaccine was not indicated accounted for 73 reports (16%). Conclusions: Reports to VAERS in the first 2 seasons of LAIV-T use did not identify any unexpected serious risks with this vaccine when used according to approved indications. Like many vaccines and other medical products, LAIV-T may rarely cause anaphylaxis. Secondary transmission of the vaccine virus merits further investigation. Reports of asthma exacerbations in vaccinees with prior asthma history highlight the risks of vaccine use inconsistent with approved labeling.
KW - adverse effects
KW - anaphylaxis
KW - asthma
KW - disease prevention
KW - Guillain-Barre syndrome
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - live vaccines
KW - safety
KW - vaccination
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - anaphylactic reactions
KW - anaphylactic shock
KW - attenuated vaccines
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053217461&site=ehost-live&scope=site
UR - http://jama.ama-assn.org/
UR - email: hector.izurieta@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein.
AU - Purdy, D. E.
AU - Chang, G. J. J.
JO - Virology
JF - Virology
Y1 - 2005///
VL - 333
IS - 2
SP - 239
EP - 250
CY - San Diego; USA
PB - Elsevier Inc
SN - 0042-6822
AD - Purdy, D. E.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20053058067. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9007-49-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology; Tropical Diseases
N2 - DNA plasmids that express flavivirus premembrane/membrane (prM/M) and envelope (E) proteins in the form of virus-like particles (VLPs) have an excellent potential as DNA vaccine candidates against virus infection. The plasmid-expressed VLPs are also useful as safe, noninfectious antigens in serodiagnostic assays. We have constructed plasmids containing the prM/M and E gene regions for DENV-1, -3, and -4 that express and secrete VLPs when electroporated into Chinese hamster ovary cells. Constructs containing the full-length DENV-1 E protein gene did not secrete VLPs into tissue culture fluid effectively. However, a 16-fold increase in ELISA titers of DENV-1 VLPs was achieved after replacing the carboxy-terminal 20% region of DENV-1 E protein gene with the corresponding sequence of Japanese encephalitis virus (JEV). DENV-3 plasmids containing either the full-length DENV-3 E protein gene or the 20% JEV sequence replacement secreted VLPs to similarly high levels. Whereas DENV-4 VLPs were secreted to high levels by plasmids containing the full-length DENV-4 E protein gene but not by the chimeric plasmid containing 20% JEV E replacement. Domain substitutions by replacing prM/M protein stem-anchor region with the corresponding prM/M stem-anchor region of JEV or DENV-2 in the chimeric DENV-4 construct failed to promote the secretion of DENV-4 VLPs. Using the DENV-2 chimeric plasmid with carboxy-terminal 10% of JEV E gene, the sequence responsible for intracellular localization of E protein was mapped onto the E-H1 α-helix domain of DENV-2 E protein. Substitution of three amino acids from the DENV-2 sequence to the corresponding amino acids in the JEV sequence (I398L, M401A, and M412L) in the E-H1 was sufficient to promote extracellular secretion and resulted in detectable titers of DENV-2 VLP secretion.
KW - amino acid sequences
KW - amino acids
KW - cell lines
KW - DNA
KW - envelope proteins
KW - gene expression
KW - genes
KW - genetic engineering
KW - in vitro
KW - molecular genetics
KW - nucleotide sequences
KW - plasmid vectors
KW - virus-like particles
KW - dengue 1 virus
KW - dengue 3 virus
KW - dengue 4 virus
KW - Japanese encephalitis virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - genetic manipulation
KW - protein sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053058067&site=ehost-live&scope=site
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model.
AU - Meseda, C. A.
AU - Garcia, A. D.
AU - Kumar, A.
AU - Mayer, A. E.
AU - Manischewitz, J.
AU - King, L. R.
AU - Golding, H.
AU - Merchlinsky, M.
AU - Weir, J. P.
JO - Virology
JF - Virology
Y1 - 2005///
VL - 339
IS - 2
SP - 164
EP - 175
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Meseda, C. A.: Laboratory of DNA Viruses, Division of Viral Products, HFM-457, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20892, USA.
N1 - Accession Number: 20053222523. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 308067-58-5.
N2 - Significant adverse events are associated with vaccination with the currently licensed smallpox vaccine. Candidate new-generation smallpox vaccines such as the replication-defective modified vaccinia virus Ankara (MVA) produce very few adverse events in experimental animals and in limited human clinical trials conducted near the end of the smallpox eradication campaign. Efficacy evaluation of such new-generation vaccines will be extraordinarily complex, however, since the eradication of smallpox precludes a clinical efficacy trial and the correlates of protection against smallpox are unknown. A combination of relevant animal efficacy studies along with thorough comparative immunogenicity studies between traditional and new-generation smallpox vaccines will be necessary for vaccine licensure. In the present study, a variety of immune responses elicited by MVA and the licensed smallpox vaccine Dryvax in a murine model were compared, with a focus on mimicking conditions and strategies likely to be employed in human vaccine trials. Immunization of mice with MVA, using several relevant vaccination routes including needle-free delivery, elicited humoral and cellular immune responses qualitatively similar to those elicited by vaccination with Dryvax. Similar levels of vaccinia-specific IgG and neutralizing antibody were elicited by Dryvax and MVA when higher doses (approximately 1 log) of MVA were used for immunization. Antibody levels peaked at about 6 weeks post-immunization and remained stable for at least 15 weeks. A booster immunization of either MVA or Dryvax following an initial priming immunization with MVA resulted in an enhanced IgG titer and neutralizing antibody response. In addition, both Dryvax and various MVA vaccination protocols elicited antibody responses to the extracellular enveloped form of the virus and afforded protection against a lethal intranasal challenge with vaccinia virus WR.
KW - animal experiments
KW - animal models
KW - antibodies
KW - antigens
KW - cell mediated immunity
KW - humoral immunity
KW - IgG
KW - immune response
KW - immunization
KW - immunogenetics
KW - neutralizing antibodies
KW - potency
KW - smallpox
KW - vaccination
KW - vaccines
KW - mice
KW - Vaccinia virus
KW - Variola virus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - animal research
KW - antigenicity
KW - cellular immunity
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053222523&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00426822
UR - email: weirj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and preliminary characterization of vaccinia virus (Dryvax) antigens recognized by vaccinia immune globulin.
AU - Jones-Trower, A.
AU - Garcia, A.
AU - Meseda, C. A.
AU - He, Y.
AU - Weiss, C.
AU - Kumar, A.
AU - Weir, J. P.
AU - Merchlinsky, M.
JO - Virology
JF - Virology
Y1 - 2005///
VL - 343
IS - 1
SP - 128
EP - 140
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Jones-Trower, A.: Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-457, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20063007338. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 308067-57-4. Subject Subsets: Veterinary Science; Public Health
N2 - Using vaccinia immune globulin (VIG), a high-titer antibody preparation from immunized subjects, we demonstrate that the humoral immune response in humans is directed against numerous antigens in the Dryvax vaccine strain. Western blot and immunoprecipitation analyses revealed highly antigenic proteins associated with both the extracellular enveloped virus and intracellular mature virus forms. The modified vaccinia virus Ankara (MVA), a new generation smallpox vaccine that is attenuated for replication in humans, expresses most, but not all, of the major vaccinia antigens recognized by antibodies in VIG, lacking the highly antigenic protein corresponding to the A-type inclusion body protein. Since new-generation smallpox vaccines such as MVA will require extensive comparison to traditional smallpox vaccines in animal models of immunogenicity and protection, we compared the vaccinia virus antigens recognized by VIG to those recognized by sera from Dryvax and MVA immunized mice. The humoral immune response in immunized mice is qualitatively similar to that in humans.
KW - antigens
KW - human diseases
KW - humoral immunity
KW - immune response
KW - immunoglobulins
KW - vaccination
KW - vaccines
KW - viral proteins
KW - man
KW - mice
KW - Vaccinia virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - antigenicity
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Animal Immunology (LL650) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063007338&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00426822
UR - email: merchlinsky@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study.
AU - Graham, D. J.
AU - Campen, D.
AU - Hui, R.
AU - Spence, M.
AU - Cheetham, C.
AU - Levy, G.
AU - Shoor, S.
AU - Ray, W. A.
JO - Lancet (British edition)
JF - Lancet (British edition)
Y1 - 2005///
VL - 365
IS - 9458
SP - 475
EP - 481
CY - London; UK
PB - Lancet Limited
SN - 0140-6736
AD - Graham, D. J.: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053027977. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Background: Controversy has surrounded the question about whether high-dose rofecoxib increases or naproxen decreases the risk of serious coronary heart disease. We sought to establish if risk was enhanced with rofecoxib at either high or standard doses compared with remote non-steroidal anti-inflammatory drug (NSAID) use or celecoxib use, because celecoxib was the most common alternative to rofecoxib. Methods: We used data from Kaiser Permanente in California, USA to assemble a cohort of all patients age 18-84 years treated with a NSAID between Jan 1, 1999, and Dec 31, 2001, within which we did a nested case-control study. Cases of serious coronary heart disease (acute myocardial infarction and sudden cardiac death) were risk-set matched with four controls for age, sex, and health plan region. Current exposure to cyclo-oxygenase 2 selective and non-selective NSAIDs was compared with remote exposure to any NSAID, and rofecoxib was compared with celecoxib. Findings: During 2 302 029 person-years of follow-up, 8143 cases of serious coronary heart disease occurred, of which 2210 (27.1%) were fatal. Multivariate adjusted odds ratios versus celecoxib were: for rofecoxib (all doses), 1.59 (95% CI 1.10-2.32, p=0.015); for rofecoxib 25 mg/day or less, 1.47 (0.99-2.17, p=0.054); and for rofecoxib greater than 25 mg/day, 3.58 (1.27-10.11, p=0.016). For naproxen versus remote NSAID use the adjusted odds ratio was 1.14 (1.00-1.30, p=0.05). Interpretation: Rofecoxib use increases the risk of serious coronary heart disease compared with celecoxib use. Naproxen use does not protect against serious coronary heart disease.
KW - adverse effects
KW - death
KW - drug therapy
KW - heart diseases
KW - human diseases
KW - myocardial infarction
KW - non-steroidal antiinflammatory agents
KW - risk
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - celecoxib
KW - chemotherapy
KW - coronary diseases
KW - heart attack
KW - naproxen
KW - NSAIDS
KW - rofecoxib
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053027977&site=ehost-live&scope=site
UR - http://www.thelancet.com/journal
UR - email: GRAHAMD@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of tetracycline residues in shrimp and whole milk using liquid chromatography with ultraviolet detection and residue confirmation by mass spectrometry.
AU - Andersen, W. C.
AU - Roybal, J. E.
AU - Gonzales, S. A.
AU - Turnipseed, S. B.
AU - Pfenning, A. P.
AU - Kuck, L. R.
A2 - Ginkel, L. A. van
A2 - Bergwerff, A. A.
A2 - Vlis, E. van der
A2 - Townshend, A.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2005///
VL - 529
IS - 1/2
SP - 145
EP - 150
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Andersen, W. C.: Animal Drugs Research Center, U.S. Food and Drug Administration, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20053035892. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 64-18-6, 110-15-6, 60-54-8, 64-75-5. Subject Subsets: Veterinary Science; Dairy Science; Veterinary Science
N2 - Two methods have been developed for the simultaneous determination of tetracycline, oxytetracycline, and chlortetracycline in shrimp and in whole milk. These methods were designed to simplify sample extraction and clean-up steps and to be fast and convenient for routine testing in a regulatory environment. Both methods rely on a simple extraction of the shrimp or milk matrix with succinic acid followed by isolation on a copolymeric solid phase extraction column. Chromatographic separation was achieved using a polar end-capped C8 column with an isocratic mobile phase consisting of organic acid, acetonitrile, and methanol, where 0.1% formic acid or 0.01 M oxalic acid was used as the acid. Formic acid allowed direct confirmation of the three residues by liquid chromatography-tandem mass spectrometry (LC-MS-MS). LC with ultraviolet absorbance at 370 nm resulted in the quantitation of all three tetracycline residues from shrimp and milk samples fortified at 50, 100, 200, 300, and 400 ng g-1. Average recoveries were greater than 75% with R.S.D. values less than 10%. All three tetracycline residues were confirmed in shrimp (25-400 ng g-1) and milk (50-300 ng g-1) samples by LC-MS-MS.
KW - analytical methods
KW - antibiotics
KW - drug residues
KW - formic acid
KW - liquid chromatography
KW - mass spectrometry
KW - milk
KW - shrimps
KW - succinic acid
KW - tetracycline
KW - Decapoda
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - achromycin
KW - analytical techniques
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053035892&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4DFX34H-1&_user=10&_handle=V-WA-A-W-CZ-MsSAYWA-UUA-U-AAABVVBUYU-AAAAUWBYYU-EYWYBYCCV-CZ-U&_fmt=summary&_coverDate=01%2F24%2F2005&_rdoc=25&_orig=browse&_srch=%23toc%235216%232005%23994709998%23560102!&_cdi=5216&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=77574843a878b6a8bb57aeb02c7d066b
UR - email: wendy.andersen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of avermectin and moxidectin residues in milk by liquid chromatography-tandem mass spectrometry using an atmospheric pressure chemical ionization/atmospheric pressure photoionization source.
AU - Turnipseed, S. B.
AU - Roybal, J. E.
AU - Andersen, W. C.
AU - Kuck, L. R.
A2 - Ginkel, L. A. van
A2 - Bergwerff, A. A.
A2 - Vlis, E. van der
A2 - Townshend, A.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2005///
VL - 529
IS - 1/2
SP - 159
EP - 165
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Turnipseed, S. B.: Animal Drugs Research Center, U.S. Food and Drug Administration, P.O. Box 25087, Denver, CO 80225, USA.
N1 - Accession Number: 20053035894. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 71751-41-2, 117704-25-3, 70288-86-7, 113507-06-5. Subject Subsets: Helminthology; Veterinary Science; Dairy Science; Veterinary Science
N2 - The avermectins - ivermectin (IVR), doramectin (DOR), eprinomectin (EPR) - and also the milbemycin moxidectin (MOX) are anthelmintic compounds that may be administered to cattle. Different ionization techniques, including atmospheric pressure photoionization (APPI), were evaluated for the detection of these residues in milk. The ionization response of these compounds using APPI was compared with that obtained by atmospheric pressure chemical ionization (APCI), a combination of APPI and APCI, and electrospray. It was found that the relative response of these drugs with different ionization protocols varied depending on the compound and the mobile phase. When monitoring negative ions, the use of the UV lamp increased the MS response. However, the best response for these compounds was obtained by operating the APCI/APPI source in the positive ion mode without any discharge current applied to the corona needle, whether the UV lamp was on or not. Using this mode of ionization, an MS-MS method was established to monitor the product ion scans of the sodiated molecular ions with an ion trap instrument. Milk fortified with these compounds (0.5-20 ng g-1) and milk samples from dosed animals were analysed after isolating the residues with a simple solid phase extraction method. EPR, DOR and IVR were confirmed in all of the extracts analysed. MOX was confirmed in all samples fortified at 5 ng g-1 or higher. Acceptable recoveries (≥60%) and relative standard deviations (R.S.D. values ≤20%) were observed for the residues at the following levels: EPR and IVR (1-20 ng g-1); DOR and MOX (5-20 ng g-1).
KW - abamectin
KW - analytical methods
KW - anthelmintics
KW - atmospheric pressure
KW - doramectin
KW - drug residues
KW - ionization
KW - ivermectin
KW - liquid chromatography
KW - mass spectrometry
KW - milbemycins
KW - milk
KW - moxidectin
KW - analytical techniques
KW - avermectin B1
KW - barometric pressure
KW - photoionization
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053035894&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4F9MJMG-3&_user=10&_handle=V-WA-A-W-CZ-MsSAYWA-UUA-U-AAABVVBUYU-AAAAUWBYYU-EYWYBYCCV-CZ-U&_fmt=summary&_coverDate=01%2F24%2F2005&_rdoc=27&_orig=browse&_srch=%23toc%235216%232005%23994709998%23560102!&_cdi=5216&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=04aac940a614a09d9674fccc93fd758e
UR - email: sherri.turnipseed@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.
AU - Doerge, D. R.
AU - Costa, G. G. da
AU - McDaniel, L. P.
AU - Churchwell, M. I.
AU - Twaddle, N. C.
AU - Beland, F. A.
T3 - Special issue: Acrylamide: genetic toxicity and exposure assessment
JO - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
Y1 - 2005///
VL - 580
IS - 1/2
SP - 131
EP - 141
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1383-5718
AD - Doerge, D. R.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20053048256. Publication Type: Journal Article. Note: Special issue: Acrylamide: genetic toxicity and exposure assessment Language: English. Number of References: 35 ref. Registry Number: 73-24-5, 73-40-5. Subject Subsets: Human Nutrition
N2 - Acrylamide (AA) is an important industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in chronic rodent bioassays. Recent findings of AA in many common starchy foods have sparked renewed interest in determining toxic mechanisms and in understanding the cancer, neurotoxicity, and reproductive risks from typical human exposures. Dosing mice and rats with AA (50 mg/kg) led to presence of glycidamide (GA) in serum and tissues. Furthermore, GA-derived DNA adducts of adenine and guanine were formed in all tissues examined, including both target tissues identified in rodent carcinogenicity bioassays and in non-target tissues. Dosing rats and mice with an equimolar amount of GA typically produced higher levels of DNA adducts than observed with AA. Kinetics of DNA adduct formation and accumulation were measured following oral administration of a single dose of AA (50 mg/kg) or from repeat dosing (1 mg/kg/day), respectively. The formation of these DNA adducts is consistent with previously reported mutagenicity of AA and GA in vitro, which involved reaction of GA with adenine and guanine bases. These results provide strong support for a genotoxic mechanism of AA carcinogenicity in rodents. The kinetic/biomarker approaches described here may represent a meaningful way to extrapolate cancer risks to actual human exposures from food, which are much lower.
KW - acrylamides
KW - adenine
KW - animal models
KW - genotoxicity
KW - guanine
KW - laboratory animals
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA adducts
KW - glycidamide
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053048256&site=ehost-live&scope=site
UR - email: ddoerge@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of putrescine and cadaverine in seafood (finfish and shellfish) by liquid chromatography using pyrene excimer fluorescence.
AU - Marks, H. S.
AU - Anderson, C. R.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2005///
VL - 1094
IS - 1/2
SP - 60
EP - 69
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Marks, H. S.: US Food and Drug Administration, Seafood Products Research Center/Pacific Regional Laboratory Northwest, 22201 23rd Drive SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20053209127. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 462-94-2, 51-45-6, 110-60-1. Subject Subsets: Medical & Veterinary Entomology; Human Nutrition
N2 - A liquid chromatography (LC) method is described for the easy determination of the biogenic diamines putrescine (PUT) and cadaverine (CAD) in canned tuna, frozen tuna loin, fresh mahimahi fillet, frozen raw shrimp, cooked lump crabmeat, and fresh and cold-smoked salmon. The method is also a useful screen for histamine (HTA). The method involves homogenization of fish tissue, extraction of biogenic amines into borate-trichloroacetic acid solution, centrifugation, and derivatization of supernatant with 1-pyrenebutanoic acid succinimidyl ester. The derivatized diamine species allow for the intramolecular excimer fluorescence of the pyrene moiety at a higher emission wavelength than is possible for the endogenous tissue monoamines, thus providing visual specificity of detection. All seafood species were fortified with 0.5, 1.0, 5.0, 10.0, and 15.0 µg/g (ppm) of PUT and CAD. Determination was based on standard graphs for PUT and CAD using peak areas with standard solutions equivalent to 0.375, 1.0, 5.0, 10.0, and 20.0 ppm in tissue. A set of five matrix controls (unfortified seafood tissue) were also analysed endogenous PUT was found in all samples except the canned tuna, and CAD found only in the shrimp, crab, and cold-smoked salmon. The background amines were thus subtracted prior to determining spike recovery. The intra-assay average recoveries ranged from 71 to 94% across species and spike levels.
KW - cadaverine
KW - canned fish
KW - crab meat
KW - fluorescence
KW - histamine
KW - liquid chromatography
KW - methodology
KW - putrescine
KW - shrimps
KW - salmon
KW - tuna
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - Scombridae
KW - Perciformes
KW - 1,5-pentanediamine
KW - methods
KW - pyrenes
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053209127&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4H8761G-B&_user=3891418&_handle=V-WA-A-W-BV-MsSAYVW-UUW-U-AABYAZEBDV-AABCDCUADV-CCDZBEVEV-BV-U&_fmt=full&_coverDate=11%2F11%2F2005&_rdoc=10&_orig=browse&_srch=%23toc%235248%232005%23989059998%23609105!&_cdi=5248&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=ace17e09d3d245ad4b188c228b748570
UR - email: heidi.marks@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developments in the US seafood safety program.
AU - Spiller, P.
A2 - Ryder, J.
A2 - Ababouch, L.
JO - FAO Fisheries Proceedings
JF - FAO Fisheries Proceedings
Y1 - 2005///
IS - 1
SP - 28
EP - 33
CY - Rome; Italy
PB - FAO Library
SN - 1813-3940
AD - Spiller, P.: Office of Seafood, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063203110. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition; Public Health
KW - bacterial diseases
KW - cardiovascular diseases
KW - fatty acids
KW - fish
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - mental disorders
KW - microbial contamination
KW - nutrition
KW - obesity
KW - outbreaks
KW - risk assessment
KW - seafoods
KW - USA
KW - man
KW - Vibrio parahaemolyticus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - fatness
KW - food contaminants
KW - mental illness
KW - omega-3 fatty acids
KW - psychiatric disorders
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063203110&site=ehost-live&scope=site
UR - http://www.fao.org
UR - email: philip.spiller@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developments in food security in the US seafood program.
AU - Spiller, P.
AU - Kraemer, D.
A2 - Ryder, J.
A2 - Ababouch, L.
JO - FAO Fisheries Proceedings
JF - FAO Fisheries Proceedings
Y1 - 2005///
IS - 1
SP - 53
EP - 58
CY - Rome; Italy
PB - FAO Library
SN - 1813-3940
AD - Spiller, P.: Office of Seafood, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063203113. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Dairy Science; Human Nutrition; World Agriculture, Economics & Rural Sociology
KW - anthrax
KW - biological warfare
KW - food contamination
KW - food industry
KW - food safety
KW - food security
KW - international trade
KW - microbial contamination
KW - milk
KW - regulations
KW - risk assessment
KW - seafoods
KW - terrorism
KW - USA
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - International Trade (EE600)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063203113&site=ehost-live&scope=site
UR - http://www.fao.org
UR - email: philip.spiller@cfsan.fda.gov\don.kraemer@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Good aquaculture practices for farmers - an update.
AU - Koonse, B.
A2 - Ryder, J.
A2 - Ababouch, L.
JO - FAO Fisheries Proceedings
JF - FAO Fisheries Proceedings
Y1 - 2005///
IS - 1
SP - 76
EP - 77
CY - Rome; Italy
PB - FAO Library
SN - 1813-3940
AD - Koonse, B.: Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063203116. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Veterinary Science
KW - aquaculture
KW - chemicals
KW - contamination
KW - drugs
KW - faecal coliforms
KW - food safety
KW - microbial contamination
KW - research
KW - seafoods
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - fecal coliforms
KW - medicines
KW - pharmaceuticals
KW - studies
KW - Research (AA500)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063203116&site=ehost-live&scope=site
UR - http://www.fao.org
UR - email: brett.koonse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The "care and feeding" of a regulatory HACCP-based system for seafood.
AU - Hansen, T.
A2 - Ryder, J.
A2 - Ababouch, L.
JO - FAO Fisheries Proceedings
JF - FAO Fisheries Proceedings
Y1 - 2005///
IS - 1
SP - 137
EP - 145
CY - Rome; Italy
PB - FAO Library
SN - 1813-3940
AD - Hansen, T.: Office of Seafood, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063203106. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition
N2 - This paper summarizes the lessons learned by the United States Food and Drug Administration with the implementation and management of an HACCP-based system for seafoods. These are: (1) seafood HACCP is high maintenance; (2) new management approaches will be needed; and (3) periodic programme evaluation is essential to ensure that a regulatory HACCP system is effective.
KW - food safety
KW - HACCP
KW - public agencies
KW - seafoods
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - government agencies
KW - hazard analysis critical control points
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063203106&site=ehost-live&scope=site
UR - http://www.fao.org
UR - email: timothy.hansen@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Drug interactions with antiretrovirals for HIV infection.
AU - Struble, K. A.
AU - Piscitelli, S. C.
A2 - Piscitelli, S. C.
A2 - Rodvold, K. A.
T2 - Drug interactions in infectious diseases
T3 - Infectious Disease
Y1 - 2005///
IS - Ed.2
CY - Totowa; USA
PB - Humana Press
SN - 1588294552
AD - Struble, K. A.: Division of Antiviral Drug Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20053199723. Publication Type: Book chapter. Note: Infectious Disease Language: English. Number of References: 88 ref. Subject Subsets: Public Health; Aromatic & Medicinal Plants; Botanical Pesticides
N2 - This chapter describes the clinically important interactions associated with the 4 classes of antiretroviral drugs, and discusses management strategies to improve patient outcome. The 4 drug classes are nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, proteinase inhibitors, and a new class of drugs that inhibits the process of human immunodeficiency virus fusion and entry (e.g., enfuvirtide). A brief discussion on the interaction of foods and herbal medicines with antiretroviral agents is provided, as well as two case reports of drug-drug interactions.
KW - antiviral agents
KW - drug metabolism
KW - drug therapy
KW - foods
KW - herbal drugs
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - interactions
KW - new drugs
KW - nutrient drug interactions
KW - pharmacokinetics
KW - proteinase inhibitors
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - enfuvirtide
KW - herbal medicines
KW - Human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - non-nucleoside reverse transcriptase inhibitors
KW - nucleoside reverse transcriptase inhibitors
KW - protease inhibitors
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053199723&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of antimicrobial use in animals and regulatory response.
AU - Tollefson, L.
A2 - Smith, R. A.
JO - Proceedings of the Thirty-Eighth Annual Convention, American Association of Bovine Practitioners, Salt Lake City, Utah, USA, 24-24 September, 2005
JF - Proceedings of the Thirty-Eighth Annual Convention, American Association of Bovine Practitioners, Salt Lake City, Utah, USA, 24-24 September, 2005
Y1 - 2005///
SP - 52
EP - 56
CY - Stillwater; USA
PB - American Association of Bovine Practitioners
AD - Tollefson, L.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20073178473. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 36 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - There is accumulating evidence that the use of antimicrobials in food-producing animals has adverse human health consequences. The use of these drugs in food animals selects for resistant pathogens and resistance genes that may be transferred to humans through the consumption or handling of foods of animal origin. Recent studies have demonstrated that antimicrobial resistance among foodborne bacteria may cause excess cases of illness, prolonged duration of illness, and increased rates of bacteremia, hospitalization and death. The US Food and Drug Administration (FDA) is committed to resolving the public health impact arising from the use of antimicrobial drugs in food-producing animals. The FDA's goal is to ensure that significant human antimicrobial therapies are not compromised or lost while providing for the safe use of antimicrobials in food animals. The FDA published a guidance document titled "Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to their Microbiological Effects on Bacteria of Human Health Concern" that outlines a pathway drug sponsors can use to address concerns about antimicrobial resistance prior to approval of their drug. The process uses a qualitative risk assessment approach to assess the potential of the intended use of a product to develop resistance in bacteria that may harm humans. The level of risk determines the level of risk management that is required for the drug to be approved.
KW - antibiotic residues
KW - antibiotics
KW - drug residues
KW - drug resistance
KW - food safety
KW - regulation
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Pesticide and Drug Resistance (HH410)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073178473&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Epidemiological approaches to studying cancer I: study design, confounding variables, misclassification, and cancer clusters.
AU - Ward, E.
A2 - Shields, P. G.
T2 - Cancer risk assessment
T3 - Basic and Clinical Oncology
Y1 - 2005///
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 0824729846\9780824729844
AD - Ward, E.: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20053217862. Publication Type: Book chapter. Note: Basic and Clinical Oncology Language: English. Number of References: 83 ref. Subject Subsets: Public Health
N2 - This chapter reviews basic concepts in the design and interpretation of epidemiological studies, focusing on their application in cancer risk assessment. Two major epidemiological study designs are described, namely, cohort and case-control designs. Factors that should be considered in the interpretation of epidemiological study results include bias, confounding and interaction variables, measurement error, and misclassification. Two main methods for combining the results of epidemiological studies are briefly described, i.e., meta-analysis and pooled analysis. The value of cluster analysis in epidemiological studies of cancer is discussed.
KW - data analysis
KW - design
KW - epidemiology
KW - human diseases
KW - meta-analysis
KW - neoplasms
KW - reviews
KW - risk assessment
KW - risk factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053217862&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Shigella species.
AU - Lampel, K. A.
A2 - Fratamico, P. M.
A2 - Bhunia, A. K.
A2 - Smith, J. L.
T2 - Foodborne pathogens: microbiology and molecular biology
Y1 - 2005///
CY - Boca Raton; USA
PB - CRC Press LLC
SN - 190445500X
AD - Lampel, K. A.: United States Food and Drug Administration, HFS-025, 8301 Muirkirk Road, Laurel, Maryland, USA.
N1 - Accession Number: 20063045990. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Tropical Diseases; Public Health
N2 - Shigella species are members of the family Enterobacteriacae and are Gram negative, non-motile rods. Four subgroups exist based on O-antigen structure and biochemical properties; S. dysenteriae (subgroup A), S. flexneri (subgroup B), S. boydii (subgroup C) and S. sonnei (subgroup D). Clinical manifestations include mild to severe diarrhoea with or without blood, fever, tenesmus, and abdominal pain. Further complications of the disease may be seizures, toxic megacolon, reactive arthritis and hemolytic uremic syndrome. Transmission of the pathogen is by the faecal-oral route, commonly through food and water. The infectious dose ranges from 10-100 organisms. Shigella spp. have a sophisticated pathogenic mechanism to invade colonic epithelial cells of the host, man and higher primates, and the ability to multiply intracellularly and spread from cell to adjacent cell via actin polymerization. Shigellae are one of the leading causes of bacterial foodborne illnesses and can spread quickly within a population.
KW - bacterial diseases
KW - clinical aspects
KW - complications
KW - diarrhoea
KW - disease transmission
KW - foodborne diseases
KW - human diseases
KW - man
KW - Shigella
KW - Shigella boydii
KW - Shigella dysenteriae
KW - Shigella flexneri
KW - Shigella sonnei
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Shigella
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - clinical picture
KW - diarrhea
KW - scouring
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063045990&site=ehost-live&scope=site
UR - email: keith.lampel@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Frontiers in antimicrobial resistance: a tribute to Stuart B. Levy.
AU - White, D. G.
AU - Alekshun, M. N.
AU - McDermott, P. F.
A2 - White, D. G.
A2 - Alekshun, M. N.
A2 - McDermott, P. F.
T2 - Frontiers in antimicrobial resistance: A Tribute to Stuart B. Levy
Y1 - 2005///
CY - Washington; USA
PB - ASM Press
SN - 1555813291
AD - White, D. G.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20053177350. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - This book provides a comprehensive overview of antimicrobial and antineoplastic drug resistance, with special emphasis on areas where Dr. Stuart Levy stimulated scientific advancements through his own research and that of his students, research fellows and colleagues. It is comprised of 40 chapters in 7 sections focusing on the current knowledge of biochemical and genetic mechanisms of antimicrobial and antineoplastic drug resistance, the ecology of resistant bacteria, the factors influencing antimicrobial resistance, and efforts in developing and implementing relevant policy and education. This book is a new major resource for infectious disease specialists, medical practitioners and students interested in a review of accumulated research on resistance among important clinical pathogens.
KW - antibiotics
KW - antiinfective agents
KW - antineoplastic agents
KW - biochemistry
KW - drug resistance
KW - genetics
KW - health education
KW - microbial ecology
KW - microorganisms
KW - neoplasms
KW - pathogens
KW - policy
KW - resistance mechanisms
KW - bacteria
KW - prokaryotes
KW - antimicrobials
KW - bacterium
KW - cancers
KW - cytotoxic agents
KW - micro-organisms
KW - Education and Training (CC100)
KW - Policy and Planning (EE120)
KW - Pesticide and Drug Resistance (HH410)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Microbial Ecology (ZZ333) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053177350&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Detecting animal tissues in feed and feed ingredients.
AU - Myers, M. J.
A2 - Sofos, J. N.
T2 - Improving the safety of fresh meat
T3 - Woodhead Publishing in Food Science and Technology
Y1 - 2005///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 9781855739550\1855739550
AD - Myers, M. J.: US Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20053156816. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science and Technology Language: English. Number of References: 50 ref. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - Issues on food safety which are related to the presence of animal tissues (especially brain and spinal cord) in feeds and feed ingredients are discussed. The different analytical systems currently used or contemplated for use for the detection of animal proteins in animal feed and feed components are discussed; these include feed microscopy, immunochemical-based assays and molecular techniques (e.g. PCR).
KW - analytical methods
KW - contamination
KW - feeds
KW - food safety
KW - immunological techniques
KW - livestock
KW - microscopy
KW - polymerase chain reaction
KW - analytical techniques
KW - feeding stuffs
KW - PCR
KW - serological techniques
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053156816&site=ehost-live&scope=site
UR - email: michael.myers@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Medicinal plants of the world, Volume 3: chemical constituents, traditional and modern medicinal uses.
AU - Ross, I. A.
A2 - Ross, I. A.
T2 - Medicinal plants of the world, Volume 3: chemical constituents, traditional and modern medicinal uses
Y1 - 2005///
CY - Totowa; USA
PB - Humana Press
SN - 1588291294
AD - Ross, I. A.: United States Food and Drug Administration, USA.
N1 - Accession Number: 20063131046. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Aromatic & Medicinal Plants; Rice; Wheat, Barley & Triticale Abstracts; Horticultural Science; Sugar Industry
N2 - This book covers the common name, botanical description, origin and distribution, traditional and medicinal uses, chemical constituents and pharmacological activities of Camellia sinensis, Cannabis sativa, Cocos nucifera, Coffea arabica, Daucus carota, Ferula assa-foetida, Correa tridentata, Hordeum vulgare, Nicotiana tabacum, Olea europaea, Oryza sativa, Plantago ovata, Saccharum officinarum, Serenoa repens, Sesamum indicum and Zingiber officinale.
KW - barley
KW - carrots
KW - chemical composition
KW - coconuts
KW - coffee
KW - distribution
KW - geographical distribution
KW - ginger
KW - hemp
KW - medicinal plants
KW - medicinal properties
KW - olives
KW - origin
KW - pharmacology
KW - plant composition
KW - rice
KW - sesame
KW - sugarcane
KW - tea
KW - tobacco
KW - wild relatives
KW - Camellia sinensis
KW - Cannabis sativa
KW - Cocos nucifera
KW - Coffea
KW - Coffea arabica
KW - Correa
KW - Daucus carota
KW - Ferula assa-foetida
KW - Hordeum vulgare
KW - Nicotiana
KW - Nicotiana tabacum
KW - Olea europaea
KW - Oryza
KW - Oryza sativa
KW - Plantago ovata
KW - Saccharum
KW - Saccharum officinarum
KW - Serenoa repens
KW - Sesamum indicum
KW - Zingiber
KW - Zingiber officinale
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Cannabis
KW - Cannabidaceae
KW - Urticales
KW - Cocos
KW - Arecaceae
KW - Arecales
KW - monocotyledons
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - Coffea
KW - Rutaceae
KW - Sapindales
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - Ferula
KW - Hordeum
KW - Poaceae
KW - Cyperales
KW - Solanaceae
KW - Solanales
KW - Nicotiana
KW - Olea
KW - Oleaceae
KW - Scrophulariales
KW - Oryza
KW - Plantago
KW - Plantaginaceae
KW - Plantaginales
KW - Saccharum
KW - Serenoa
KW - Sesamum
KW - Pedaliaceae
KW - Zingiberaceae
KW - Zingiberales
KW - Zingiber
KW - Araliales
KW - beniseed
KW - chemical constituents of plants
KW - Correa tridentata
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Oleales
KW - paddy
KW - Rutales
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Biological Resources (Plant) (PP720)
KW - Non-food/Non-feed Plant Products (SS200)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination and speciation of trace elements in foods.
AU - Capar, S. G.
AU - Szefer, P.
A2 - Ötles, S.
T2 - Methods of analysis of food components and additives
T3 - Chemical and Functional Properties of Food Components Series
Y1 - 2005///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849316472\9780849316470
AD - Capar, S. G.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20083212171. Publication Type: Book chapter. Note: Chemical and Functional Properties of Food Components Series Language: English. Number of References: 371 ref. Registry Number: 7440-38-2, 7439-97-6. Subject Subsets: Human Nutrition
N2 - The following topics associated with determination and speciation of trace elements in food are covered in this chapter: preparation of analytical solutions; determination by atomic absorption spectrometry; determination by inductively coupled plasma; determination by inductively coupled plasma mass spectrometry; other determinative techniques (electrochemical and colorimetry); and element speciation (arsenic, mercury, selenium, tin and other chemical elements).
KW - analytical methods
KW - arsenic
KW - colorimetry
KW - food composition
KW - foods
KW - mass spectrometry
KW - mercury
KW - spectrometry
KW - trace elements
KW - analytical techniques
KW - microelements
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of pollutants in foods.
AU - Hayward, D. G.
A2 - Ötles, S.
T2 - Methods of analysis of food components and additives
T3 - Chemical and Functional Properties of Food Components Series
Y1 - 2005///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849316472\9780849316470
AD - Hayward, D. G.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20083212178. Publication Type: Book chapter. Note: Chemical and Functional Properties of Food Components Series Language: English. Number of References: 78 ref. Subject Subsets: Human Nutrition
N2 - The following techniques utilized in the detection and determination of pollutants in food are discussed: matrix separation and analyte purification; class separations and automation; isomer-specific separations (high-resolution gas chromatography); fast gas chromatography (GC); multidimensional GC; detection systems; and bio-analytical methods.
KW - analytical methods
KW - detection
KW - food contamination
KW - foods
KW - gas chromatography
KW - pollutants
KW - toxic substances
KW - analytical techniques
KW - food contaminants
KW - poisons
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Pollution and Degradation (PP600)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of food allergens and genetically modified components.
AU - Williams, K. M.
AU - Trucksess, M. W.
AU - Raybourne, R. B.
AU - Orlandi, P. A.
AU - Levy, D.
AU - Lampel, K. A.
AU - Westphal, C. D.
A2 - Ötles, S.
T2 - Methods of analysis of food components and additives
T3 - Chemical and Functional Properties of Food Components Series
Y1 - 2005///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849316472\9780849316470
AD - Williams, K. M.: U.S. Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20083212176. Publication Type: Book chapter. Note: Chemical and Functional Properties of Food Components Series Language: English. Number of References: 103 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - This chapter focuses on the detection of allergenic components of food (immunochemical methods such as ELISA, dipstick and lateral flow methods and biosensors; and DNA-based methods such as polymerase chain reaction (PCR) and PCR-ELISA). It also considers the analysis of genetically modified foods.
KW - allergens
KW - analytical methods
KW - biosensors
KW - ELISA
KW - food
KW - food composition
KW - genetically engineered foods
KW - polymerase chain reaction
KW - analytical techniques
KW - enzyme linked immunosorbent assay
KW - genetically modified food
KW - genetically modified foods
KW - GM foods
KW - PCR
KW - Food Composition and Quality (QQ500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Techniques and Methodology (ZZ900)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Uranium in food and water: actual and potential effects.
AU - Baratta, E. J.
A2 - Preedy, V. R.
A2 - Watson, R. R.
T2 - Reviews in food and nutrition toxicity. Volume 3
Y1 - 2005///
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 0849335167\9780849335167
AD - Baratta, E. J.: U.S. Food and Drug Administration, Winchester, Massachusetts, USA.
N1 - Accession Number: 20053122613. Publication Type: Book chapter. Language: English. Number of References: 16 ref. Registry Number: 7440-61-1, 7732-18-5. Subject Subsets: Human Nutrition; Public Health
N2 - Uranium is a naturally radioactive element that exists in the form of two naturally occurring isotopes, uranium-238 and uranium-235. A third isotope, uranium-234, is the decay product of uranium-238. These three radioactive isotopes are normally found in a certain percentage, and there are some areas in the world where uranium is more abundant than other elements. It had only limited use prior to 1939; however, after the development of the atomic bomb, it was mined extensively. Enriched uranium-235 was used to make atomic weapons and as a power source (in nuclear reactors). Uranium-235 is also used to produce radiopharmaceuticals for medical use. The depleted uranium-238 (product of the enrichment of uranium-235) has been used in the production of armor-piercing projectiles. It is also used as a radiation shielding material. The exposure of the body to uranium via ingestion and inhalation was initially of concern to the health of the workers handling this chemical. Later, it became of concern to the health of the general population because it could find its way into the body through ingestion via food and water. This chapter discusses the exposure limits set by various agencies and their possible effects.
KW - drinking water
KW - exposure
KW - food
KW - food contamination
KW - food safety
KW - human diseases
KW - public health
KW - radionuclides
KW - reviews
KW - toxicity
KW - uranium
KW - water
KW - water pollution
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - radioactive isotopes
KW - radioactive nuclides
KW - radioisotopes
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Fluoride - toxic and pathologic aspects: review of current literature on some aspects of fluoride toxicity.
AU - Collins, T. F. X.
AU - Sprando, R. L.
A2 - Preedy, V. R.
A2 - Watson, R. R.
T2 - Reviews in food and nutrition toxicity. Volume 4
Y1 - 2005///
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 0849335191\9780849335198
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20053122631. Publication Type: Book chapter. Language: English. Number of References: many ref. Registry Number: 9007-49-2, 7782-41-4. Subject Subsets: Human Nutrition; Public Health
N2 - Humans are exposed to fluorides, which are ubiquitous compounds, primarily through water, food, dental products, and air. The use of fluoridated water in the preparation of foods and beverages at commercial establishments and at home, coupled with fluoride in dental products, has led to increased consumption of fluorides. Fluorides can produce wide-ranging effects on many tissues, organs, and systems in the body. Fluorides are toxic at high concentrations, but at low concentrations they are added to drinking water to prevent the formation of dental caries. In mammals, fluorides have a high affinity for teeth and bones. Consumption of excess fluoride during the time of tooth enamel formation in children can cause dental fluorosis, marked by discoloured or "mottled" teeth. Skeletal fluorosis, marked by symptoms ranging from slight pain to crippling deformities, is an additive disease, for which daily consumption of high levels of fluoride for many years is usually required. In addition to teeth and bones, fluoride can also affect kidneys, lungs, and the nervous system, and it can disturb hormones and possibly change genetics. Treatment of male animals with high levels has indicated that fluoride can affect testicular production in mice and rabbits, but not always in rats. Treatment of female rats and rabbits with sodium fluoride during several generations failed to produce reproductive effects, but a high concentration of fluoride decreased bone ossification in rats.
KW - air
KW - bone diseases
KW - bones
KW - central nervous system
KW - DNA
KW - drinking water
KW - exposure
KW - fluorides
KW - fluorine
KW - fluorosis
KW - food
KW - genotoxicity
KW - hormones
KW - human diseases
KW - infants
KW - kidney diseases
KW - kidneys
KW - lungs
KW - nephrotoxicity
KW - nervous system diseases
KW - respiratory diseases
KW - reviews
KW - teeth
KW - tooth diseases
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - CNS
KW - deoxyribonucleic acid
KW - kidney disorders
KW - lung diseases
KW - nephropathy
KW - neuropathy
KW - renal diseases
KW - Water Resources (PP200)
KW - Food Composition and Quality (QQ500)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Immunology of HIV-1.
AU - Devadas, K.
AU - Lal, R. B.
AU - Dhawan, S.
A2 - Gendelman, H. E.
A2 - Grant, I.
A2 - Everall, I. P.
A2 - Lipton, S. A.
A2 - Swindells, S.
T2 - The neurology of AIDS
Y1 - 2005///
CY - Oxford; UK
PB - Oxford University Press
SN - 0198526105
AD - Devadas, K.: Immunopathogenesis Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063112502. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - This chapter provides a description of the molecular and structural biology of the human deficiency virus-1 (HIV-1) and the immunological consequences that viral infection produces. Discussed in this chapter are the immune response in HIV-1 infection, clinical manifestations, infection of the peripheral and central nervous systems, viral tropism and pathogenesis.
KW - cell ultrastructure
KW - human diseases
KW - immune response
KW - immunity
KW - immunopathology
KW - nervous system diseases
KW - replication
KW - tropisms
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human immunodeficiency virus type 1
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - neuropathy
KW - virions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Morphology of Microorganisms (ZZ392) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Clinical approach to the patient with a possible tick-borne illness.
AU - Goodman, J. L.
A2 - Goodman, J. L.
A2 - Dennis, D. T.
A2 - Sonenshine, D. E.
T2 - Tick-borne diseases of humans
Y1 - 2005///
CY - Washington; USA
PB - ASM Press
SN - 1555812384
AD - Goodman, J. L.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Suite 200N, HFM-1, Rockville, MD 20852, USA.
N1 - Accession Number: 20053101303. Publication Type: Book chapter. Language: English. Number of References: 11 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
KW - diagnosis
KW - diagnostic techniques
KW - drug therapy
KW - fever
KW - geographical distribution
KW - human diseases
KW - laboratory diagnosis
KW - nervous system diseases
KW - skin diseases
KW - symptoms
KW - tickborne diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - dermatoses
KW - neuropathy
KW - pyrexia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Tick-borne diseases of humans.
AU - Goodman, J. L.
AU - Dennis, D. T.
AU - Sonenshine, D. E.
A2 - Goodman, J. L.
A2 - Dennis, D. T.
A2 - Sonenshine, D. E.
T2 - Tick-borne diseases of humans
Y1 - 2005///
CY - Washington; USA
PB - ASM Press
SN - 1555812384
AD - Goodman, J. L.: Centre for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Suite 200N, HFM-1, Rockville, Maryland 20852, USA.
N1 - Accession Number: 20053101238. Publication Type: Book. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science; Medical & Veterinary Entomology; Protozoology; Public Health
N2 - Tick-borne illnesses are extremely diverse, both biologically and clinically, and symptoms are often non-specific, making recognition and appropriate treatment challenging. This book aims to provide a comprehensive account of tick-borne diseases that affect humans, addressing both the vectors and the diseases. 20 chapters, each written by field experts, cover key information useful to students and professionals in the fields of human and veterinary medicine, public health, medical entomology, acarology and ecology. The first section provides an overview of ticks, including their biology, ecology and identification, the distribution of the diseases which they transmit, the clinical approach needed to diagnose a possible tick-borne illness, and strategies for tick control. The second section includes chapters devoted to specific diseases, covering aspects such as history, biology, epidemiology, ecology, transmission, clinical manifestations, diagnosis, treatment and prevention. The diseases covered are Colorado tick fever, tick-borne encephalitis, Crimean-Congo haemorrhagic fever, Lyme borreliosis, tularaemia, ehrlichioses, relapsing fever, Rocky Mountain and other spotted fever group rickettsioses, Mediterranean spotted fever, Q fever and human babesiosis. The third section contains colour illustrations providing geographic distribution maps of tickborne disease and their vectors, with an accompanying chapter of text, and an atlas of clinical and pathologic images useful for diagnosis.
KW - babesiosis
KW - diagnosis
KW - disease control
KW - disease prevention
KW - disease transmission
KW - disease vectors
KW - ecology
KW - ehrlichioses
KW - epidemiology
KW - geographical distribution
KW - human diseases
KW - identification
KW - Lyme disease
KW - Mediterranean spotted fever
KW - pathology
KW - Q fever
KW - Rocky Mountain spotted fever
KW - spotted fever
KW - therapy
KW - tickborne diseases
KW - tickborne encephalitis
KW - tickborne relapsing fever
KW - tularaemia
KW - vector control
KW - zoonoses
KW - animals
KW - Babesia
KW - Borrelia
KW - Borrelia burgdorferi
KW - Colorado tick fever virus
KW - Coxiella
KW - Crimean-Congo haemorrhagic fever virus
KW - Ehrlichia
KW - Francisella tularensis
KW - man
KW - Metastigmata
KW - Rickettsia conorii
KW - Rickettsia rickettsii
KW - Rickettsiales
KW - Tick-borne encephalitis virus
KW - eukaryotes
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Borrelia
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Coxiellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Nairovirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Acari
KW - Arachnida
KW - arthropods
KW - Rickettsia
KW - Rickettsiaceae
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - abattoir fever
KW - bacterium
KW - Balkan grippe
KW - boutonneuse fever
KW - Central European encephalitis virus
KW - Colorado tick fever
KW - Crimean-Congo haemorrhagic fever
KW - Crimean-Congo hemorrhagic fever virus
KW - Derrick-Burnet disease
KW - Ehrlichia infections
KW - ehrlichiosis
KW - lyme borreliosis
KW - Nine Mile fever
KW - pneumorickettsiosis
KW - quadrilateral fever
KW - query fever
KW - red water
KW - therapeutics
KW - tick fever
KW - Tickborne encephalitis virus
KW - tularemia
KW - zoonotic infections
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Zoology of Wild Animals (Vertebrates and Invertebrates) (General) (YY000) (New March 2000)
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DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - New developments in chemical and microbial risk assessment.
AU - Buchanan, R.
AU - Suhre, B.
A2 - Hoffmann, S. A.
A2 - Taylor, M. R.
T2 - Toward safer food: perspectives on risk and priority setting
Y1 - 2005///
CY - Washington; USA
PB - Resources for the Future
SN - 1891853902
AD - Buchanan, R.: U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition, USA.
N1 - Accession Number: 20053113971. Publication Type: Book chapter. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - This chapter examines state of the art chemical and microbial risk assessment. It also describes how two major food safety regulatory agencies, the US Environmental Protection Agency and the Food and Drug Administration, assess risks. The refinements in chemical risk assessment motivated by the 1996 Food Quality Protection Act and the recent development of quantitative microbial risk assessment are highlighted.
KW - food quality
KW - food safety
KW - public agencies
KW - risk
KW - risk assessment
KW - government agencies
KW - Food Contamination, Residues and Toxicology (QQ200)
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DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance and genetic relatedness among Salmonella from retail foods of animal origin: NARMS retail meat surveillance.
AU - Zhao, S.
AU - McDermott, P. F.
AU - Friedman, S.
AU - Abbott, J.
AU - Ayers, S.
AU - Glenn, A.
AU - Hall-Robinson, E.
AU - Hubert, S. K.
AU - Harbottle, H.
AU - Walker, R. D.
AU - Chiller, T. M.
AU - White, D. G.
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
Y1 - 2006///
VL - 3
IS - 1
SP - 106
EP - 117
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20073195146. Publication Type: Journal Article. Language: English. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 80370-57-6, 57-92-1, 60-54-8, 64-75-5. Subject Subsets: Human Nutrition; Pig Science; Poultry
N2 - Salmonella isolates were recovered from a monthly sampling of chicken breasts, ground turkey, ground beef, and pork chops purchased from selected grocery stores in six participating FoodNet sites (Connecticut, Georgia, Maryland, Minnesota, Oregon, and Tennessee) in 2002 and an additional two sites in 2003 (California and New York). In 2002 and 2003, a total of 6,046 retail meats were examined, including 1,513 chicken breasts, 1,499 ground turkey samples, 1,522 ground beef samples, and 1,502 pork chops. Retail meat samples tested increased to 3,533 in 2003 as compared to 2,513 in 2002. Overall, six percent of 6,046 retail meat samples (n=365) were contaminated with Salmonella, the bulk recovered from either ground turkey (52%) or chicken breast (39%). Salmonella isolates were serotyped and susceptibility tested using a panel of 16 antimicrobial agents. S. Heidelberg was the predominant serotype identified (23%), followed by S. Saintpaul (12%), S. Typhimurium (11%), and S. Kentucky (10%). Overall, resistance was most often observed to tetracycline (40%), streptomycin (37%), ampicillin (26%), and sulfamethoxazole (25%). Twelve percent of isolates were resistant to cefoxitin and ceftiofur, though only one isolate was resistant to ceftriaxone. All isolates were susceptible to amikacin and ciprofloxacin; however, 3% of isolates were resistant to nalidixic acid and were almost exclusive to ground turkey samples (n=11/12). All Salmonella isolates were analysed for genetic relatedness using pulsed-field gel electrophoresis (PFGE) patterns generated by digestion with Xba1 or Xba1 plus Bln1. PFGE fingerprinting profiles showed that Salmonella, in general, were genetically diverse with a total of 175 Xba1 PFGE profiles generated from the 365 isolates. PFGE profiles showed good correlation with serotypes and in some instances, antimicrobial resistance profiles. Results demonstrated a varied spectrum of antimicrobial resistance and PFGE patterns, including several multidrug resistant clonal groups among Salmonella isolates, and signify the importance of sustained surveillance of foodborne pathogens in retail meats.
KW - ampicillin
KW - antibiotics
KW - antiinfective agents
KW - antimicrobial properties
KW - beef
KW - ceftiofur
KW - chicken meat
KW - contamination
KW - digestion
KW - electrophoresis
KW - foodborne diseases
KW - foods
KW - meat
KW - pathogens
KW - pigmeat
KW - poultry
KW - streptomycin
KW - surveillance
KW - tetracycline
KW - California
KW - Connecticut
KW - Georgia
KW - Kentucky
KW - Maryland
KW - Minnesota
KW - New York
KW - Oregon
KW - Tennessee
KW - USA
KW - fowls
KW - Salmonella
KW - Salmonella typhimurium
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - New England States of USA
KW - Northeastern States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Southeastern States of USA
KW - Appalachian States of USA
KW - East South Central States of USA
KW - Lake States of USA
KW - North Central States of USA
KW - West North Central States of USA
KW - Middle Atlantic States of USA
KW - Pacific Northwest States of USA
KW - achromycin
KW - anti-microbial properties
KW - antimicrobials
KW - bacterium
KW - chickens
KW - domesticated birds
KW - pork
KW - United States of America
KW - Pesticides and Drugs (General) (HH400)
KW - Meat Produce (QQ030)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073195146&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/abs/10.1089/fpd.2006.3.106
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn production.
AU - Boylstein, R.
AU - Piacitelli, C.
AU - Grote, A.
AU - Kanwal, R.
AU - Kullman, G.
AU - Kreiss, K.
T2 - Journal of Occupational and Environmental Hygiene
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2006///
VL - 3
IS - 10
SP - 530
EP - 535
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Boylstein, R.: National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA.
N1 - Accession Number: 20073099354. Publication Type: Journal Article. Language: English. Registry Number: 431-03-8. Subject Subsets: Public Health; Soyabeans
N2 - In microwave popcorn workers, exposure to butter flavourings has been associated with fixed obstructive lung disease resembling bronchiolitis obliterans. Inhalation toxicology studies have shown severe respiratory effects in rats exposed to vapours from a paste butter flavouring, and to diacetyl, a diketone found in most butter flavourings. To gain a better understanding of worker exposures, we assessed diacetyl emissions and airborne dust levels from butter flavourings used by several microwave popcorn manufacturing companies. We heated bulk samples of 40 different butter flavourings (liquids, pastes and powders) to approximately 50°C and used gas chromatography, with a mass selective detector, to measure the relative abundance of volatile organic compounds emitted. Air sampling was conducted for diacetyl and for total and respirable dust during the mixing of powder, liquid or paste flavourings with heated soyabean oil at a microwave popcorn plant. To further examine the potential for respiratory exposures to powders, we measured dust generated during different simulated methods of manual handling of several powder butter flavourings. Powder flavourings gave off much lower diacetyl emissions than pastes or liquids. The mean diacetyl emissions from liquids and pastes were 64 and 26 times larger than the mean of diacetyl emissions from powders, respectively. The median diacetyl emissions from liquids and pastes were 364 and 72 times larger than the median of diacetyl emissions from powders, respectively. 14 of 16 powders had diacetyl emissions that were lower than the diacetyl emissions from any liquid flavouring and from most paste flavourings. However, simulated handling of powder flavourings showed that a substantial amount of the airborne dust generated was of respirable size and could thus pose its own respiratory hazard. Companies that use butter flavourings should consider substituting flavourings with lower diacetyl emissions and the use of ventilation and enclosure engineering controls to minimize exposures. Until controls are fully implemented, companies should institute mandatory respiratory protection for all exposed workers.
KW - air
KW - diacetyl
KW - dust
KW - flavourings
KW - food additives
KW - human diseases
KW - liquids
KW - microwave cooking
KW - occupational hazards
KW - occupational health
KW - organic compounds
KW - pastes
KW - popcorn
KW - powders
KW - respiratory diseases
KW - volatile compounds
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - flavorings
KW - lung diseases
KW - organic chemicals
KW - volatile constituents
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099354&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a772837010~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viewpoint on non-clinical pharmacokinetic evaluation of traditional Chinese medicine and natural medicine.
AU - Han Ling
AU - Zhu JiaGu
JO - Chinese Journal of Natural Medicines
JF - Chinese Journal of Natural Medicines
Y1 - 2006///
VL - 4
IS - 6
SP - 473
EP - 476
CY - Nanjing; China
PB - Chinese Journal of Natural Medicines
SN - 1672-3651
AD - Han Ling: Center for Drug Evaluation, State Food and Drug Administration, Beijing 100038, China.
N1 - Accession Number: 20063235745. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 5 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - This paper presents viewpoints on non-clinical pharmacokinetic studies of traditional Chinese medicine and natural medicine for new drug registration. The purpose and basic principle for non-clinical pharmacokinetic study are analysed and discussed. Suggestions including comprehensive evaluation and analysis in the non-clinical pharmacokinetic study are provided.
KW - medicinal plants
KW - pharmacokinetics
KW - traditional Chinese medicines
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063235745&site=ehost-live&scope=site
UR - http://zgtryw.periodicals.net.cn
UR - email: hanling92@sina.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Update: cohort mortality study of workers highly exposed to polychlorinated biphenyls (PCBs) during the manufacture of electrical capacitors, 1940-1998.
AU - Prince, M. M.
AU - Hein, M. J.
AU - Ruder, A. M.
AU - Waters, M. A.
AU - Laber, P. A.
AU - Whelan, E. A.
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
Y1 - 2006///
VL - 5
IS - 13
SP - (22 May 2006)
EP - (22 May 2006)
CY - London; UK
PB - BioMed Central Ltd
SN - 1476-069X
AD - Prince, M. M.: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluation and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073184624. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - Background: The National Institute for Occupational Safety and Health previously reported mortality for a cohort of workers considered highly exposed to polychlorinated biphenyls (PCBs) between 1939 and 1977 at two electrical capacitor manufacturing plants. The current study updated vital status, examined liver and rectal cancer mortality previously reported in excess in this cohort and evaluated mortality from non-Hodgkin's lymphoma (NHL) and cancers of the stomach, intestine, breast, prostate, skin (melanoma) and brain reported to be in excess in other cohort and case-control studies of PCB-exposed persons. Methods: Mortality was updated through 1998 for 2572 workers. Age-, gender-, race- and calendar year-adjusted standardized mortality ratios (SMRs) and 95% confidence intervals (CI) were calculated using U.S., state and county referent rates. SMRs using U.S. referent rates are reported. Duration of employment was used as a surrogate for exposure. Results: Consistent with the previous follow-up, mortality from biliary passage, liver and gall bladder cancer was significantly elevated (11 deaths, SMR 2.11, CI 1.05-3.77), but mortality from rectal cancer was not (6 deaths, SMR 1.47, CI 0.54-3.21). Among women, mortality from intestinal cancer (24 deaths, SMR 1.89, CI 1.21-2.82) and from "other diseases of the nervous system and sense organs", which include Parkinson's disease and amyotrophic lateral sclerosis, (15 deaths, SMR 2.07, CI 1.16-3.42) were elevated. There were four ALS deaths, all women (SMR 4.35, CI 1.19-11.14). Mortality was elevated for myeloma (7 deaths, SMR 2.11, CI 0.84-4.34), particularly among workers employed 10 years or more (5 deaths, SMR 2.80, CI 0.91-6.54). No linear associations between mortality and duration of employment were observed for the cancers of interest. Conclusion: This update found that the earlier reported excess in this cohort for biliary, liver and gall bladder cancer persisted with longer follow-up. Excess mortality for intestinal cancer among women was elevated across categories of duration of employment; myeloma mortality was highest among those working 10 years or more. The small numbers of deaths from liver and intestinal cancers, myeloma and nervous system diseases coupled with the lack of an exposure-response relationship with duration of employment preclude drawing definitive conclusions regarding PCB exposure and these causes of death.
KW - bladder
KW - bladder cancer
KW - bladder diseases
KW - brain
KW - case studies
KW - causes of death
KW - follow up
KW - gall bladder
KW - human diseases
KW - liver
KW - lymphoma
KW - melanoma
KW - mortality
KW - myeloma
KW - neoplasms
KW - nervous system
KW - nervous system diseases
KW - non-Hodgkin's lymphoma
KW - Parkinson's disease
KW - polychlorinated biphenyls
KW - prostate
KW - rectum
KW - safety
KW - safety at work
KW - sclerosis
KW - stomach
KW - women
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - amyotrophic lateral sclerosis
KW - cancers
KW - cerebrum
KW - death rate
KW - neuropathy
KW - occupational safety
KW - PCBs
KW - urinary bladder
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Demography (UU200)
KW - Occupational Health and Safety (VV900)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073184624&site=ehost-live&scope=site
UR - http://www.ehjournal.net/content/pdf/1476-069X-5-13.pdf
UR - email: mmprince12@earthlink.net\zcr9@cdc.gov\amr2@cdc.gov\maw0@cdc.gov\pal0@cdc.gov\eaw0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health care for children and youth in the United States: annual report on patterns of coverage, utilization, quality, and expenditures by a county level of urban influence.
AU - Chevarley, F. M.
AU - Owens, P. L.
AU - Zodet, M. W.
AU - Simpson, L. A.
AU - McCormick, M. C.
AU - Dougherty, D.
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
Y1 - 2006///
VL - 6
IS - 5
SP - 241
EP - 264
CY - New York; USA
PB - Elsevier
SN - 1530-1567
AD - Chevarley, F. M.: Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20063193031. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Objective: To examine child and hospital demographics and children's health care coverage, use, expenditures, and quality by a county-level measure of urban influence, in the USA. Methods: Two national health care databases serve as the sources of data for this report: the 2002 Medical Expenditure Panel Survey (MEPS) and the 2002 Nationwide Inpatient Sample (NIS) and State Inpatient Databases (SID) from the Healthcare Cost and Utilization Project (HCUP). In both data sets, county urbanicity is defined by use of a collapsed version of the 2003 Urban Influence Codes, to distinguish among children residing in and hospitals located in large metropolitan (metro) counties, small metro counties, micropolitan counties, and noncore counties. Results: Demographical analysis showed that in large metro counties, greater percentages of the child population are Hispanic or black non-Hispanic than in small metro, micropolitan, and noncore counties; in micropolitan and noncore counties, higher proportions of children are below 200% of the federal poverty level than in large metro and small metro counties. Noncore areas have a greater percentage of children in fair or poor health compared with those in small metro and micropolitan counties. Most hospitals are located in large and small metro areas, and large metro areas have a higher proportion of teaching hospitals compared with other areas. In terms of health care in general, there were no overall differences by place of residence in the proportion of children with and without insurance, although differences emerged in subpopulations within Urban Influence Code types. Hispanic children residing in large metro counties were more likely to be uninsured than those in small metro counties. Overall, the proportion of children with at least one dental visit was larger in small metro areas compared with both large metro and noncore areas. The proportion of children with medicines prescribed was generally lower in large metro areas compared with all other areas both overall and among subpopulations of children. Children in noncore areas were more likely to have a hospital inpatient stay and any emergency department use compared with children in large metro areas. Children in large metro counties had longer average inpatient stays and a higher hospital inpatient charge per day compared with children in all other counties. Although most hospitalizations for children from large metro areas occurred in large metro areas, over half of hospitalizations for noncore children occurred outside of noncore counties. Furthermore, children from noncore counties appear to be hospitalized for ambulatory sensitive conditions more than children from all other areas. Conclusions: County-level data analyses performed using a collapsed version of the Urban Influence Codes with MEPS and HCUP data shed additional light on the health care patterns for children that were not previously evident when only the dichotomous metropolitan/nonmetropolitan geographic schema was used.
KW - children
KW - costs
KW - coverage
KW - ethnicity
KW - expenditure
KW - health care
KW - health insurance
KW - Hispanics
KW - urban areas
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - ethnic differences
KW - United States of America
KW - Health Services (UU350)
KW - Health Economics (EE118) (New March 2000)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063193031&site=ehost-live&scope=site
UR - http://www.ambulatorypediatrics.org
UR - email: Fran.Chevarley@AHRQ.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identifying outbreaks of sexually transmitted infection: who cares?
AU - Werber, D.
AU - Evans, M. R.
AU - Thomas, D. R.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2006///
VL - 6
IS - 264
SP - (24 October 2006)
EP - (24 October 2006)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2458
AD - Werber, D.: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Cardiff, Wales, UK.
N1 - Accession Number: 20063226783. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - Background: Current routine surveillance schemes for sexually transmitted infections (STIs) in the United Kingdom (UK) are not designed for outbreak identification. Recognising STI outbreaks, therefore, depends almost entirely on the alertness of health professionals. The objective of this study was to explore health professionals' knowledge of, and attitudes towards, identification and investigation of STI outbreaks in Wales. Methods: We conducted a cross-sectional survey in Wales in June 2005, and sent a questionnaire to consultants of genitourinary medicine (GUM, n=11), a consultant microbiologist from each laboratory (n=14), all consultants in communicable disease control (n=5), and to epidemiologists of the National Public Health Service (n=4). Results: 26 (76%) of 34 survey recipients responded. Of these, 17 (65%) ranked the investigation of STI outbreaks as important or very important, and 19 (73%) perceived participation in the investigation of an STI outbreak as part of their responsibility. Only six (25%) respondents had actively searched their computer system or patient records for a possible STI outbreak in the previous twelve months, and 15 (63%) had never looked for an outbreak. Of seven GUM physicians who said they had identified at least one STI outbreak, three had never informed public health authorities. Conclusion: Prompt identification and coordinated investigation of outbreaks, usually through a multidisciplinary outbreak control team, is central to the control of many infectious diseases. This does not appear to be the case for STIs, which we believe represents a lost opportunity to reduce transmission. Besides improved surveillance methods, a change in culture towards STI outbreaks is needed among health professionals in Wales.
KW - attitudes
KW - health care workers
KW - human diseases
KW - knowledge
KW - outbreaks
KW - physicians
KW - sexually transmitted diseases
KW - surveys
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - doctors
KW - STDs
KW - United Kingdom
KW - venereal diseases
KW - Health Services (UU350)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063226783&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/content/pdf/1471-2458-6-264.pdf
UR - email: werberd@rki.de\Meirion.Evans@nphs.wales.nhs.uk\Daniel.Thomas@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Developing a community health promotion agenda for a managed care organization.
AU - Burwen, D. R.
AU - Sylvester, C. C.
AU - Patow, C. A.
JO - Health Promotion Practice
JF - Health Promotion Practice
Y1 - 2006///
VL - 7
IS - 1
SP - 86
EP - 94
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 1524-8399
AD - Burwen, D. R.: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063013205. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Coordination and collaboration between organizations interested in promoting the health of the populations they serve can potentially help to ensure that key services are provided as well as augment the efforts beyond that which could be accomplished by each organization alone. Understanding the perspectives of each organization can facilitate development of health promotion initiatives that will be of mutual benefit. In Maryland, USA, when a Medicaid managed care program was initiated, Memoranda of Understanding were signed between each managed care organization (MCO) and each of the 24 local health departments; many stipulated that the parties will coordinate on community health issues. This report describes a telephone survey of the health departments that was performed by one MCO to better understand the interests and expectations of the health departments and discusses a process for developing a community health promotion agenda for an MCO.
KW - community health
KW - health promotion
KW - health services
KW - preventive medicine
KW - Maryland
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063013205&site=ehost-live&scope=site
UR - http://hpp.sagepub.com/cgi/content/abstract/7/1/86
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inactivation of Clostridium botulinum nonproteolytic type B spores by high pressure processing at moderate to elevated high temperatures.
AU - Reddy, N. R.
AU - Tetzloff, R. C.
AU - Solomon, H. M.
AU - Larkin, J. W.
JO - Innovative Food Science & Emerging Technologies
JF - Innovative Food Science & Emerging Technologies
Y1 - 2006///
VL - 7
IS - 3
SP - 169
EP - 175
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1466-8564
AD - Reddy, N. R.: National Center for Food Safety and Technology, Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063172215. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 14265-44-2.
N2 - The effect of high pressure and high temperature treatments at various process times on the inactivation of spores of Clostridium botulinum nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B, suspended in phosphate buffer (0.067 M, pH 7.0) and a crabmeat blend was investigated. Spores of KAP8-B were less resistant to high pressure treatment than the spores of 2-B, 17-B, and KAP9-B in both phosphate buffer and crabmeat blend. No survivors of initial counts (>4.3 log units) of KAP8-B spores were detected in these menstrua after processing at 827 MPa and 60°C for 10 min. The amount of inactivation of spores of 2-B, 17-B, and KAP9-B in phosphate buffer or crabmeat blend increased with the increase in processing time from 10 to 30 min at 827 MPa and 75°C. Similar inactivation patterns were observed for these spores in both phosphate buffer and crabmeat blend. A reduction of >6-log units of 2-B, 17-B, and KAP9-B spores in phosphate buffer and crabmeat blend was observed at 827 MPa and 75°C for a processing time of between 20 and 30 min. Crabmeat blend as a suspension menstrum provided no protection against inactivation of spores of 2-B, 17-B, and KAP9-B by high pressure processing. High temperature (>95°C) and lower pressure (620 MPa) treatments for up to 10 min were also found to inactivate 17-B spores in phosphate buffer. Spores of nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B in phosphate buffer and crabmeat blend can be inactivated by a combination of high pressure and temperature treatments.
KW - bacterial count
KW - bacterial spores
KW - crab meat
KW - phosphate
KW - pressure regulators
KW - proteolysis
KW - temperature
KW - Clostridium botulinum
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Aquatic Produce (QQ060)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063172215&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/14668564
UR - email: rukma.reddy@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A transdisciplinary approach to improve health literacy and reduce disparities.
AU - Lloyd, L. L. J.
AU - Ammary, N. J.
AU - Epstein, L. G.
AU - Johnson, R.
AU - Rhee, K.
JO - Health Promotion Practice
JF - Health Promotion Practice
Y1 - 2006///
VL - 7
IS - 3
SP - 331
EP - 335
CY - Thousand Oaks; USA
PB - Sage Publications
SN - 1524-8399
AD - Lloyd, L. L. J.: Center for Quality at the Health Resources and Services Administration (HRSA), Rockville, Maryland, USA.
N1 - Accession Number: 20063136665. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - A challenge to public health professionals, health care providers, and consumers is to come together to improve the quality of health care and to eliminate disparities. Improving health literacy skills along with a transdisciplinary approach to care contributes to effective patient-provider communication. This article addresses a team approach to health care, a community health centre experience, self-management skills, patient education, and cultural competency training. In addition, the authors provide concepts that can be incorporated in health care settings to eliminate health disparities and improve health literacy.
KW - health care
KW - health centres
KW - health education
KW - health services
KW - literacy
KW - public health
KW - self care
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - health centers
KW - inequality
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063136665&site=ehost-live&scope=site
UR - http://hpp.sagepub.com/cgi/content/abstract/7/3/331
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Airborne endotoxin in woodworking (joinery) shops.
AU - Harper, M.
AU - Andrew, M. E.
A2 - Thomassen, Y.
A2 - Levin, Y-O.
A2 - Harper, M.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2006///
VL - 8
IS - 1
SP - 73
EP - 78
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 1464-0325
AD - Harper, M.: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073117903. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 22 ref. Subject Subsets: Forest Products
N2 - Symptoms such as shortness of breath and cough have been noted in woodworking facilities even where wood dust itself is well-controlled. Suspicion has fallen on other possible contaminants in the workplace atmosphere, including bacterial endotoxin. A few studies have indicated potentially high endotoxin exposure with exposure to fresh wood in sawmills and in the production of fiberboard and chipboard, but fewer studies have been carried out on exposure to endotoxin in dry wood work, for example in joineries. A study of the endotoxin content of airborne wood dust samples from US woodworking facilities is presented, from the re-analysis of samples which previously had been taken to establish mass collection relationships between the IOM sampler, the closed-face 37 mm plastic cassette (CFC) sampler and the Button sampler. Endotoxin was strongly correlated with total dust, but the endotoxin content of a few fresh wood samples was found to be up to ten times higher per unit of wood dust than for dried-wood samples, and this difference was significant. No long-term time-weighted average sample exceeded the recommended limit value of 50 EU m-3 (EU, endotoxin units) used in the Netherlands, although a number of the IOM samples came close (seven samples or 44% exceeded 20 EU m-3) and one short-term (48 minute) sample registered a high value of 73 EU m-3. The geometric mean concentration from the IOM samples (11 EU m-3) is within the range of geometric means found from Australian joineries (3.7-60, combined: 24 EU m-3). In contrast, the corresponding values from the CFC (3.6 EU m-3), and the Button sampler (2.1 EU m-3) were much lower and no samples exceeded 20 EU m-3. Endotoxin is likely only to be a significant problem in working with dried woods when associated with very high dust levels, where the wood dust itself is likely to be a cause for concern. The results from the few samples in this study where fresh wood was being worked were similar to results from other studies involving fresh woods. The agreement between these studies is encouraging given the difficulties of endotoxin analysis and the wide variation often expected between different laboratories.
KW - endotoxins
KW - joinery
KW - particle size
KW - safety at work
KW - wood dust
KW - woodworking
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Logging and Wood Processing (KK515)
KW - Toxinology (VV820) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Industrial Wastes and Effluents (XX400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073117903&site=ehost-live&scope=site
UR - http://www.rsc.org/delivery/_ArticleLinking/DisplayArticleForFree.cfm?doi=b508065g&JournalCode=EM
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Myeloid differentiation factor-88 (MyD88) is essential for control of primary in vivo Francisella tularensis LVS infection, but not for control of intramacrophage bacterial replication.
AU - Collazo, C. M.
AU - Sher, A.
AU - Meierovics, A. I.
AU - Elkins, K. L.
JO - Microbes and Infection
JF - Microbes and Infection
Y1 - 2006///
VL - 8
IS - 3
SP - 779
EP - 790
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1286-4579
AD - Collazo, C. M.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA.
N1 - Accession Number: 20063102723. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Registry Number: 9008-11-1. Subject Subsets: Medical & Veterinary Entomology
N2 - The means by which Francisella tularensis, the causative agent of tularaemia, are recognized by mammalian immune systems are poorly understood. Here we wished to explore the contribution of the MyD88/Toll-like receptor signalling pathway in initiating murine responses to F. tularensis Live Vaccine Strain (LVS). MyD88 knockout (KO) mice, but not TLR2-, TLR4- or TLR9-deficient mice, rapidly succumbed following in vivo bacterial infection via the intradermal route even with a very low dose of LVS (5×101) that was 100 000-fold less than the LD50 of normal wild-type (WT) mice. By day 5 after LVS infection, bacterial organ burdens were 5-6 logs higher in MyD88 knockout mice; further, unlike infected WT mice, levels of interferon-γ in the sera of LVS-infected MyD88 KO were undetectable. An in vitro culture system was used to assess the ability of bone marrow macrophages derived from either KO or WT mice to support bacterial growth, or to control intracellular bacterial replication when co-cultured with immune lymphocytes. In this assay, bacterial replication was similar in macrophages derived from either WT or any of the TLR KO mice. Bacterial growth was controlled in co-cultures containing macrophages from MyD88 KO mice or TLR KO mice as well as in co-cultures containing immune WT splenic lymphocytes and WT macrophages. Further, MyD88-deficient LVS-immune splenocytes controlled intracellular growth comparably to those from normal mice. Thus, MyD88 is essential for innate host resistance to LVS infection, but is not required for macrophage control of intracellular bacterial growth.
KW - disease models
KW - experimental infections
KW - human diseases
KW - immunology
KW - interferon
KW - laboratory animals
KW - lymphocytes
KW - macrophages
KW - splenocytes
KW - tularaemia
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - tularemia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063102723&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/12864579
UR - email: karen.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The genetic and environmental factors involved in benzidine metabolism and bladder carcinogenesis in exposed workers.
AU - Carreón, T.
AU - LeMasters, G. K.
AU - Ruder, A. M.
AU - Schulte, P. A.
JO - Frontiers in Bioscience
JF - Frontiers in Bioscience
Y1 - 2006///
VL - 11
IS - 1
SP - 2889
EP - 2902
CY - Albertson; USA
PB - Frontiers in Bioscience Inc.
SN - 1093-9946
AD - Carreón, T.: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073243788. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Genetic susceptibility to bladder cancer in individuals exposed to arylamines may be explained by interindividual metabolic differences that lead to arylamine bioactivation or detoxification. In this article, occupational bladder cancer risk factors and the evidence that links benzidine exposure to bladder cancer are reviewed. Benzidine metabolism is described and compared with that of other aromatic amines. Metabolic polymorphisms and bladder cancer in the context of occupational exposure to aromatic amines are also reviewed, and the environmental and genetic relationships of benzidine exposure and genetic susceptibility are outlined. Only a few studies of bladder cancer genetic susceptibility in populations exposed occupationally to arylamines have been published. The results of these case-control studies show conflicting results, reflecting metabolic differences between monoarylamines and diarylamines such as benzidine. Additional studies and pooled analyses of existing data are needed to establish if individuals are at higher risk of bladder cancer given the presence of certain alleles that make them more susceptible to this disease.
KW - alleles
KW - amines
KW - aromatic compounds
KW - bladder
KW - bladder cancer
KW - bladder diseases
KW - carcinogenesis
KW - case studies
KW - detoxification
KW - environmental factors
KW - environmental health
KW - exposure
KW - human diseases
KW - neoplasms
KW - occupational hazards
KW - public health
KW - risk factors
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aromatic amines
KW - aromatics
KW - benzidine
KW - cancers
KW - genetic relationships
KW - urinary bladder
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073243788&site=ehost-live&scope=site
UR - http://www.bioscience.org/2006/v11/af/2017/list.htm
UR - email: tjc5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatal work-related injuries in the agriculture production sector among youth in the United States, 1992-2002.
AU - Hard, D. L.
AU - Myers, J. R.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2006///
VL - 11
IS - 2
SP - 57
EP - 65
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - Hard, D. L.: Centers for Disease Control & Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis & Field Evaluations Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073034489. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Youth working on farms face unique risks that are not present for many other young workers, including machinery, large animals, electrical hazards, chemical hazards and excessive noise. This research identified the number and rate of occupational fatalities for youth working in the agriculture production industry, which is most closely affiliated with farming, for the years 1992-2002. The Census of Fatal Occupational Injuries (CFOI), developed by the Bureau of Labor Statistics (BLS), was the database used for the analysis. There were 310 work-related deaths to youth less than 20 years of age from 1992 through 2002 in the agriculture production sector. This compares to 1,958 total fatalities for all workers less than 20 years of age for the same time period. The number of agricultural production fatalities to youth has shown a general downward trend over this time period. The rates were higher for young workers in agriculture production than for young workers in all industries by a factor of 3.6. Fifteen year olds had the highest fatality rates with the crop production sector having a rate six times that of all 15 year old workers. The objective of this descriptive research was to identify, prioritize and publicize the risks to children and youth who work on farms in order to provide public health and safety professionals relevant information upon which to base decisions for interventions or other prevention activities for this priority population. This research also has direct applications for farm parents and safety and health professionals who work with the priority population of young agricultural workers.
KW - accidents
KW - adolescents
KW - children
KW - farm workers
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupational health
KW - trauma
KW - young workers
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - teenagers
KW - traumas
KW - United States of America
KW - youth employment
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073034489&site=ehost-live&scope=site
UR - http://www.haworthpress.com/web/JA/
UR - email: DHard@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The novel use of 'Asian' as an ethnic category in the New Zealand health sector.
AU - Rasanathan, K.
AU - Craig, D.
AU - Perkins, R.
JO - Ethnicity & Health
JF - Ethnicity & Health
Y1 - 2006///
VL - 11
IS - 3
SP - 211
EP - 227
CY - Basingstoke; UK
PB - Routledge
SN - 1355-7858
AD - Rasanathan, K.: Auckland Regional Public Health Service, Private Bag 92 605, Symonds Street, Auckland, New Zealand.
N1 - Accession Number: 20063133401. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - 'Asian' is increasingly used as an ethnic category in the health sector in New Zealand but does not have a 'natural', fixed, uncontested meaning. Two differing constructions of 'Asian' are commonly used in New Zealand. One is racially based and includes only East and Southeast Asian peoples. It is commonly employed in popular discourse and by the media. The other construction includes peoples from East, South and Southeast Asia, but excludes peoples from the Middle East and Central Asia. This construction is recent and unique to New Zealand and is being increasingly operationalised in the health sector. This use for planning and research is problematic. For the health sector, 'Asian' does not differentiate a group of people with shared characteristics in terms of health status or needs. The diversity of the 'Asian' category, with several axes of difference, will result in an averaging of health indicators. This may result in the high health needs of groups within this category being masked or the inappropriate targeting of services. Another major concern is the general lack of acknowledgement of the contestable nature of the 'Asian' category or justification for its use. However, the 'Asian' category provides a political platform to advocate for resources and enable research into the previously ignored health status of the diverse 'Asian' population. Despite its shortcomings, usage of the category is likely to continue in the New Zealand health sector. As such, the sector needs to be aware of the limitations of the category and show greater precision in its use.
KW - Asians
KW - ethnic groups
KW - ethnicity
KW - health
KW - health care
KW - terminology
KW - New Zealand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - ethnic differences
KW - Demography (UU200)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063133401&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102212
UR - email: kumananr@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk of introduction of poliovirus into a Dutch Cape Verdian community during an outbreak of poliovirus in Cape Verde, 2000.
AU - Mertens, P. L. J. M.
AU - Widdowson, M. A.
AU - Avoort, H. G. A. M. van der
AU - Richardus, J. H.
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
Y1 - 2006///
VL - 11
IS - 5
SP - 746
EP - 750
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1360-2276
AD - Mertens, P. L. J. M.: Municipal Public Health Service, Rotterdam, Netherlands.
N1 - Accession Number: 20063114107. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 17 ref. Subject Subsets: Tropical Diseases; Leisure, Recreation, Tourism; Rural Development
N2 - OBJECTIVE: To assess the risk of introduction of polio virus in a Cape Verdian community of Rotterdam, during the polio epidemic in Cape Verde in 2000. METHODS: All 225 insufficiently vaccinated 0-14-year-old Cape Verdian children (n=4188) and a random sample of 285 out of all 15-30-year-old Cape Verdians (n=5074) in Rotterdam were surveyed to assess travel behaviour and vaccination coverage. Faecal specimens were collected and sewage samples taken in neighbourhoods with a sizable Cape Verdian population for testing of polio virus. RESULTS: During the polio epidemic in Cape Verde, 10% of insufficiently vaccinated children aged 0-14 years and 17% of adults aged 15-30 years living in Rotterdam reported travelling to Cape Verde. 94.6% of Cape Verdians in Rotterdam aged 0-14 years were sufficiently vaccinated against polio, but 9 of 91 insufficiently vaccinated children had travelled to Cape Verde during the epidemic. Of those aged 15-30 years, 10% were not vaccinated against polio. In the faeces of 80 insufficiently vaccinated individuals aged 0-14 years and in 74 adults aged 15-30 years, no poliovirus was detected. Samples of sewage from six sites were negative for poliovirus. CONCLUSION: No evidence of poliovirus infection was found in the Cape Verde population in Rotterdam despite extensive travel to the Cape Verde during the outbreak.
KW - adolescents
KW - adults
KW - children
KW - epidemics
KW - human diseases
KW - immunization
KW - imported infections
KW - outbreaks
KW - poliomyelitis
KW - risk assessment
KW - travel
KW - travellers
KW - vaccination
KW - viral diseases
KW - Cape Verde
KW - Netherlands
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - ACP Countries
KW - Atlantic Ocean Islands
KW - Least Developed Countries
KW - Developing Countries
KW - Portuguese Speaking Africa
KW - Africa
KW - West Africa
KW - Africa South of Sahara
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - immune sensitization
KW - polio
KW - teenagers
KW - viral infections
KW - Tourism and Travel (UU700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063114107&site=ehost-live&scope=site
UR - email: paul.mertens@wxs.nl
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vision and oral health needs of individuals with intellectual disability.
AU - Owens, P. L.
AU - Kerker, B. D.
AU - Zigler, E.
AU - Horwitz, S. M.
A2 - Frey, G. C.
A2 - Temple, V. A.
A2 - Stanish, H. I.
T2 - Mental Retardation and Developmental Disabilities Research Reviews
T3 - Special issue: Preventive health and individuals with mental retardation.
JO - Mental Retardation and Developmental Disabilities Research Reviews
JF - Mental Retardation and Developmental Disabilities Research Reviews
Y1 - 2006///
VL - 12
IS - 1
SP - 28
EP - 40
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 1080-4013
AD - Owens, P. L.: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20063159675. Publication Type: Journal issue. Note: Special issue: Preventive health and individuals with mental retardation. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - Over the past 20 years, there has been an increased emphasis on health promotion, including prevention activities related to vision and oral health, for the general population, but not for individuals with intellectual disability (ID). This review explores what is known about the prevalence of vision problems and oral health conditions among individuals with ID, presents a rationale for the increased prevalence of these conditions in the context of service utilization, and examines the limitations of the available research. Available data reveal a wide range of prevalence estimates for vision problems and oral health conditions, but all suggest that these conditions are more prevalent among individuals with ID compared with the general population, and disparities exist in the receipt of preventive and early treatment for these conditions for individuals with ID. Recommendations for health improvement in these areas include better health planning and monitoring through standardized population-based data collection and reporting and increased emphasis on health promotion activities and early treatment in the healthcare system.
KW - cataract
KW - dental caries
KW - dental health
KW - disease prevalence
KW - Down's syndrome
KW - epidemiology
KW - eye diseases
KW - eyes
KW - gingivitis
KW - human diseases
KW - mental retardation
KW - morbidity
KW - people with mental disabilities
KW - periodontal diseases
KW - systematic reviews
KW - vision
KW - vision disorders
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - caries
KW - gum disease
KW - mental deficiency
KW - mentally handicapped
KW - mentally handicapped people
KW - mentally handicapped persons
KW - mongolism
KW - sight
KW - teeth caries
KW - tooth decay
KW - visual impairments
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063159675&site=ehost-live&scope=site
UR - http://www.inderscience.wiley.com
UR - email: powens@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational health survey of farm workers by camp health aides.
AU - Cameron, L.
AU - Lalich, N.
AU - Bauer, S.
AU - Booker, V.
AU - Bogue, H. O.
AU - Samuels, S.
AU - Steeg, A. L.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2006///
VL - 12
IS - 2
SP - 139
EP - 153
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Cameron, L.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20063114754. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health; Agricultural Engineering; Soils & Fertilizers; World Agriculture, Economics & Rural Sociology
N2 - Little is known about the magnitude of occupational health problems among migrant farm workers. A community-based cross-sectional survey was conducted in two migrant farm worker communities: Homestead, Florida, and Kankakee, Illinois. Camp Health Aides (CHAs) interviewed 425 workers about job tasks, personal protective equipment (PPE), field sanitation, work exposures, and selected health conditions. Limited provision of personal protective equipment was reported among those reporting early re-entry tasks: 35% in Kankakee and 42% in Homestead were provided gloves, and 22% in Homestead and 0% in Kankakee were provided protective clothing. About two-thirds were provided toilet facilities and water for hand-washing. Workers reported high prevalences of health conditions consistent with exposure to ergonomic hazards and pesticides. The prevalence of back pain in the past 12 months was 39% in Homestead and 24% in Kankakee. Among Homestead participants, 35% experienced eye symptoms, while 31% reported skin symptoms. These symptoms were less prevalent among Kankakee participants (16% for both eye and skin symptoms). Specific areas of concern included back pain associated with heavy lifting and ladder work; eye and skin irritation associated with fertilizer application tasks and with working in fields during or after spraying of chemicals, especially early re-entry of sprayed fields; and skin irritation associated with a lack of access to hand-washing facilities. In both Kankakee and Homestead, better adherence to safety standards is needed, as well as greater efforts to implement solutions that are available to help prevent work-related musculoskeletal problems.
KW - ergonomics
KW - exposure
KW - eye diseases
KW - farm workers
KW - fertilizers
KW - migrant farm workers
KW - migrants
KW - occupational health
KW - pesticide residues
KW - pesticides
KW - safety at work
KW - sanitation
KW - skin diseases
KW - toxicity
KW - trauma
KW - working conditions
KW - Florida
KW - Illinois
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - dermatoses
KW - fertilisers
KW - human engineering
KW - occupational safety
KW - traumas
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Fertilizers and other Amendments (JJ700)
KW - Labour and Employment (EE900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063114754&site=ehost-live&scope=site
UR - email: nina.lalich@case.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Standardization of an antihemorrhagic potency test of antivenoms prepared from two different Agkistrodon halys venoms.
AU - Lee, K. H.
AU - Hur, S. J.
AU - Kim, S. N.
AU - Yoo, S. H.
AU - Shin, I. S.
AU - Won, H. J.
AU - Shin, K. H.
AU - Hong, S. H.
AU - Lee, S. H.
AU - Min, H. K.
AU - Park, S. N.
JO - Journal of Venomous Animals and Toxins including Tropical Diseases
JF - Journal of Venomous Animals and Toxins including Tropical Diseases
Y1 - 2006///
VL - 12
IS - 3
SP - 456
EP - 475
CY - Botucatu; Brazil
PB - Center for the Study of Venoms and Venomous Animals CEVAP, UNESP
SN - 0104-7930
AD - Lee, K. H.: Department of Biologics Evaluation, Korea Food and Drug Administration, 231, Jinheoungno, Eunpyeong-Gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20073175606. Publication Type: Journal Article. Language: English. Number of References: 9 ref.
N2 - To establish Korea National Standards for venoms and antivenoms, it is necessary to have standardized assay methods. In this study, we standardized a method to evaluate the antihemorrhagic potency of two horse-derived antivenoms using rabbit intracutaneous injection. We expressed the capability of these antivenoms to neutralize the hemorrhagic activities triggered by the venoms of Agkistrodon halys from Japan and Jiangzhe Agkistrodon halys from China as Minimum Hemorrhagic Dose (MHD). We also performed cross-neutralization tests employing the parallel line assay on different pairings of venoms and antivenoms to check the possibility of using Jiangzhe Agkistrodon halys venom as a substitute for the standard Agkistrodon halys venom in measurements of the antihemorrhagic activity, since A. halys venom is not easily available. Slope function ratio (S.R.) was 0.957 for Agkistrodon halys venom either with Agkistrodon halys antivenom or with Jiangzhe Agkistrodon halys antivenom (p>0.05). Similarly, S.R. was 0.348 for Jiangzhe Agkistrodon halys venom either with Agkistrodon halys antivenom or with Jiangzhe Agkistrodon halys antivenom (p>0.05). Thus, in this study we established antihemorrhagic potency test methods for both Agkistrodon halys and Jiangzhe Agkistrodon halys antivenoms and we could also show it is possible to use Jiangzhe Agkistrodon halys venom as a standard.
KW - animal models
KW - antivenoms
KW - drug development
KW - haemorrhage
KW - laboratory animals
KW - venoms
KW - Gloydius halys
KW - rabbits
KW - Agkistrodon
KW - Viperidae
KW - snakes
KW - reptiles
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - mammals
KW - Gloydius
KW - Agkistrodon halys
KW - antivenins
KW - bleeding
KW - hemorrhage
KW - venom
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073175606&site=ehost-live&scope=site
UR - http://www.scielo.br/pdf/jvatitd/v12n3/31233.pdf
UR - email: suenie@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Upper Midwest health study: a case-control study of primary intracranial gliomas in farm and rural residents.
AU - Ruder, A. M.
AU - Waters, M. A.
AU - Carreón, T.
AU - Butler, M. A.
AU - Davis-King, K. E.
AU - Calvert, G. M.
AU - Schulte, P. A.
AU - Ward, E. M.
AU - Connally, L. B.
AU - Lu, J.
AU - Wall, D.
AU - Zivkovich, Z.
AU - Heineman, E. F.
AU - Mandel, J. S.
AU - Morton, R. F.
AU - Reding, D. J.
AU - Rosenman, K. D.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2006///
VL - 12
IS - 4
SP - 255
EP - 274
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Ruder, A. M.: National Institute for Occupational Safety and Health, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063227243. Publication Type: Journal Article. Corporate Author: USA, Brain Cancer Collaborative Study Group Language: English. Number of References: many ref. Subject Subsets: Public Health; Medical & Veterinary Entomology; Agricultural Engineering
N2 - Since several studies indicated that farmers and agricultural workers had an excess risk of brain cancer, the National Institute for Occupational Safety and Health initiated the Upper Midwest Health Study to examine risk of intracranial glioma in the non-metropolitan population. This population-based, case-control study evaluated associations between gliomas and rural and farm exposures among adults (ages 18 to 80) in four upper midwestern states (Iowa, Michigan, Minnesota, Wisconsin). At diagnosis/selection, participants lived in non-metropolitan counties where the largest population center had fewer than 250,000 residents. Cases were diagnosed 1 January 1995 through 31 January 1997. Over 90% of 873 eligible ascertained cases and over 70% of 1670 eligible controls consented to participate. Participants and nonparticipants, evaluated for "critical questions" on main and refusant questionnaires, differed significantly in farming and occupational experience, ethnicity, education, and lifestyle. The 1175 controls were more likely than the 798 cases to have reported ever drinking alcohol (77% vs. 73%, adjusted odds ratio (OR) 0.73, 95% confidence interval (CI) 0.59-0.92) and having had panoramic dental x-rays (34% vs. 29%, OR 0.75, CI 0.61-0.92). Controls spent a greater percentage of their lives in non-metropolitan counties (78% vs. 75%, OR 0.81, CI 0.67-1.09). Among ever-farmers, controls were more likely to have had exposure to farm insecticides (57% vs. 50%, OR 0.75, CI 0.59-0.95) and farm animals (96% vs. 91%, OR 0.48, CI 0.25-0.90). Moving to a farm as an adolescent (ages 11 to 20) vs. as an adult was associated with a greater risk of glioma (OR 1.96, CI 1.13-3.39). In our study sample, farm or rural residence and summary farm exposures were associated with decreased glioma risk. However, nonparticipation by never-farming eligible controls could have affected results. Comparisons of farm chemical exposures may clarify associations between farming and glioma that others have reported.
KW - brain
KW - epidemiology
KW - exposure
KW - glioma
KW - human diseases
KW - insecticides
KW - neoplasms
KW - risk factors
KW - rural areas
KW - Iowa
KW - Michigan
KW - Minnesota
KW - USA
KW - Wisconsin
KW - animals
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - cancers
KW - cerebrum
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063227243&site=ehost-live&scope=site
UR - http://www.asabe.org/
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Standardization of anti-lethal toxin potency test of antivenoms prepared from two different Agkistrodon halys venoms.
AU - Lee, K. H.
AU - Won, H. J.
AU - Kim, S. N.
AU - Yoo, S. H.
AU - Shin, I. S.
AU - Shin, K. H.
AU - Hong, S. H.
AU - Lee, S. H.
AU - Min, H. K.
AU - Park, S. N.
AU - Hur, S. J.
JO - Journal of Venomous Animals and Toxins including Tropical Diseases
JF - Journal of Venomous Animals and Toxins including Tropical Diseases
Y1 - 2006///
VL - 12
IS - 4
SP - 560
EP - 577
CY - Botucatu; Brazil
PB - Center for the Study of Venoms and Venomous Animals CEVAP, UNESP
SN - 0104-7930
AD - Lee, K. H.: Department of Biologics Evaluation, Korea Food and Drug Administration, 231, Jinheungno, Eunpyeong-Gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20073043161. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Tropical Diseases
N2 - In Korea, antivenoms for the treatment of patients bitten by venomous snakes have been imported from Japan or China. Although there is cross-reactivity between these antibodies and venoms from snakes indigenous to Korea Republic (e.g. Agkistrodon genus), protection is not optimal. Antivenoms specifically prepared to neutralize Korean snake venoms could be more effective, with fewer side effects. To this end, we established an infrastructure to develop national standards and created a standardized method to evaluate the efficacy of two horse-derived antivenoms using mouse lethal toxin test. Additionally, we determined the antivenoms neutralizing activity against lethal doses (LD50) of Agkistrodon halys (from Japan) and Jiangzhe Agkistrodon halys (from China) venoms. We also performed cross-neutralization tests using probit analysis on each pairing of venom and antivenom in order to check the possibility of using Jiangzhe A. halys venom as a substitute for A. halys venom, the current standard. Slope of A. halys venom with A. halys antivenom was 10.2 and that of A. halys venom with Jiangzhe A. halys antivenom was 9.6. However, Slope of Jiangzhe A. halys venom with A. halys antivenom was 4.7 while that of Jiangzhe A. halys venom with Jiangzhe A. halys antivenom was 11.5. Therefore, the significant difference in slope patterns suggests that Jiangzhe A. halys venom cannot be used as a substitute for the standard venom to test the anti-lethal toxin activity of antivenoms (p<0.05).
KW - antivenoms
KW - toxins
KW - venoms
KW - Korea Republic
KW - Gloydius halys
KW - Agkistrodon
KW - Viperidae
KW - snakes
KW - reptiles
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - Gloydius
KW - Agkistrodon halys
KW - antivenins
KW - South Korea
KW - venom
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073043161&site=ehost-live&scope=site
UR - http://www.scielo.br/pdf/jvatitd/v12n4/04.pdf
UR - email: hursj@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV transmission in correctional facility.
AU - Macher, A.
AU - Kibble, D.
AU - Wheeler, D.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006///
VL - 12
IS - 4
SP - 669
EP - 671
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Macher, A.: US Public Health Service, Bethesda, Maryland, USA.
N1 - Accession Number: 20063084293. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 30516-87-1, 154598-52-4, 134678-17-4. Subject Subsets: Public Health
N2 - Acute retroviral syndrome developed in an inmate in a detention center after he had intercourse with 2 HIV-infected inmates. Correctional facilities house a disproportionate number of HIV-infected persons, and most do not provide inmates with condoms. Correctional healthcare providers should be familiar with primary HIV infection and acute retroviral syndrome.
KW - antiretroviral agents
KW - antiviral agents
KW - case reports
KW - clinical aspects
KW - correctional institutions
KW - disease transmission
KW - efavirenz
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - lamivudine
KW - multiple drug therapy
KW - prisoners
KW - sexual transmission
KW - sexually transmitted diseases
KW - viral diseases
KW - zidovudine
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AZT
KW - clinical picture
KW - combination drug therapy
KW - human immunodeficiency virus infections
KW - STDs
KW - United States of America
KW - venereal diseases
KW - venereal transmission
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063084293&site=ehost-live&scope=site
UR - email: abemacher@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Historical Lassa fever reports and 30-year clinical update.
AU - Macher, A. M.
AU - Wolfe, M. S.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006///
VL - 12
IS - 5
SP - 835
EP - 837
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Macher, A. M.: US Public Health Service (retired), Bethesda, Maryland, USA.
N1 - Accession Number: 20063097273. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Tropical Diseases
N2 - Five cases of Lassa fever have been imported from West Africa to the United States since 1969. We report symptoms of the patient with the second imported case and the symptoms and long-term follow-up on the patient with the third case. Vertigo in this patient has persisted for 30 years.
KW - human diseases
KW - imported infections
KW - Lassa fever
KW - Sierra Leone
KW - USA
KW - Lassa virus
KW - man
KW - Arenavirus
KW - Arenaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Least Developed Countries
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063097273&site=ehost-live&scope=site
UR - email: abemacher@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rodent-associated Bartonella febrile illness, Southwestern United States.
AU - Iralu, J.
AU - Bai, Y.
AU - Crook, L.
AU - Tempest, B.
AU - Simpson, G.
AU - McKenzie, T.
AU - Koster, F.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006///
VL - 12
IS - 7
SP - 1081
EP - 1086
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Iralu, J.: US Public Health Service, Gallup, New Mexico, USA.
N1 - Accession Number: 20063143590. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Serum specimens from 114 patients hospitalized with a febrile illness were tested with an indirect immunofluorescence assay (IFA) using Bartonella antigens prepared from 6 species of sigmodontine rodents and 3 known human Bartonella pathogens: B. henselae, B. quintana, and B. elizabethae. Acute- and convalescent-phase serum samples from 5 of these patients showed seroconversion with an IFA titer ≥512 to rodent-associated Bartonella antigens. The highest titer was against antigen derived from the white-throated woodrat (Neotoma albigula), although this rodent is not necessarily implicated as the source of infection. Three of the 5 who seroconverted showed no cross-reaction to the 3 Bartonella human pathogens. Common clinical characteristics were fever, chills, myalgias, leukopenia, thrombocytopenia, and transaminasemia. Although antibodies to Bartonella are cross-reactive, high-titer seroconversions to rodent-associated Bartonella antigens in adults with common clinical characteristics should stimulate the search for additional Bartonella human pathogens.
KW - clinical aspects
KW - human diseases
KW - reservoir hosts
KW - USA
KW - Bartonella
KW - Bartonella elizabethae
KW - Bartonella henselae
KW - Bartonella quintana
KW - man
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Bartonella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - animal reservoirs
KW - bacterium
KW - clinical picture
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063143590&site=ehost-live&scope=site
UR - email: fkoster@lrri.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Qualitative assessment of risk for monkeypox associated with domestic trade in certain animal species, United States.
AU - Bernard, S. M.
AU - Anderson, S. A.
A2 - Marano, N.
A2 - Arguin, P.
A2 - Pappaioanou, M.
A2 - Butler, J. C.
T3 - Special Issue: Zoonotic diseases.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006///
VL - 12
IS - 12
SP - 1827
EP - 1833
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Bernard, S. M.: US Food and Drug Administration, 3100 Paint Branch Pkwy, HFS-004, College Park, MD 20740, USA.
N1 - Accession Number: 20073001376. Publication Type: Journal Article. Note: Special Issue: Zoonotic diseases. Language: English. Number of References: 38 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - In 2003, US officials identified several human monkeypox cases and traced the virus exposure to infected captive prairie dogs. The virus was likely introduced through a shipment of imported African rodents, which were kept with other mammals, including prairie dogs, in a pet distribution facility in the Midwest. To prevent the further introduction and spread of the virus, federal agencies restricted the importation of African rodents and restricted the domestic trade or movement of prairie dogs and certain other rodents. In this qualitative assessment of the risk for monkeypox associated with the 2003 outbreak, we conclude that the probability of further human infection is low; the risk is further mitigated by rodent import restrictions. Were this zoonotic disease to become established domestically, the public health effects could be substantial.
KW - disease transmission
KW - human diseases
KW - imported infections
KW - monkeypox
KW - outbreaks
KW - risk
KW - risk factors
KW - zoonoses
KW - USA
KW - man
KW - Monkeypox virus
KW - rodents
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073001376&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: susan.bernard@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Infectious disease control in relation to xenotransplantation in Korea.
AU - Park KyoungSik
AU - Sung DeukYong
T2 - Xenotransplantation
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2006///
VL - 13
IS - 4
SP - 366
EP - 367
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0908-665X
AD - Park KyoungSik: National Institute of Toxicological Research, Korea Food and Drug Administration, Eunpyung-ku, Seoul, Korea Republic.
N1 - Accession Number: 20063131717. Publication Type: Correspondence. Language: English. Number of References: 1 ref. Subject Subsets: Tropical Diseases; Veterinary Science; Pig Science; Veterinary Science
N2 - This article discusses the guidelines of the Korea Food and Drug Administration (KFDA) on xenotransplantation to construct a constitutional basis for regulating medical treatment by xenotransplantation. This involves the grading of pig-related viral pathogens into those that need to be excluded from the organ-source herd into either mandatory, recommended or optional. This grading will provide helpful criteria in the quarantine and microbial quality control of organ-source pig herds for xenotransplantation.
KW - disease control
KW - disease prevention
KW - disease transmission
KW - guidelines
KW - organs
KW - surgery
KW - xenografts
KW - xenotransplantation
KW - zoonoses
KW - Korea Republic
KW - man
KW - pigs
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - heterografts
KW - heterotransplants
KW - hogs
KW - recommendations
KW - South Korea
KW - swine
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063131717&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1399-3089.2006.00301.x
UR - email: pks0322@hanmail.net\dysung@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid, sensitive, and specific lateral-flow immunochromatographic device to measure anti-anthrax protective antigen immunoglobulin G in serum and whole blood.
AU - Biagini, R. E.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Snawder, J. E.
AU - Robertson, S. A.
AU - Quinn, C. P.
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2006///
VL - 13
IS - 5
SP - 541
EP - 546
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Biagini, R. E.: Division of Applied Research and Technology, Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, Biological Monitoring Research Team, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention MS C-26, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063107749. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - Evidence from animals suggests that anti-anthrax protective antigen (PA) immunoglobulin G (IgG) from vaccination with anthrax vaccine adsorbed (AVA) is protective against Bacillus anthracis infection. Measurement of anti-PA IgG in human sera can be performed using either enzyme-linked immunosorbent assay or fluorescent covalent microsphere immunoassay (ELISA) (R. E. Biagini, D. L. Sammons, J. P. Smith, B. A. MacKenzie, C. A. Striley, V. Semenova, E. Steward-Clark, K. Stamey, A. E. Freeman, C. P. Quinn, and J. E. Snawder, Clin. Diagn. Lab. Immunol. 11:50-55, 2004). Both these methods are laboratory based. We describe the development of a rapid lateral-flow immunochromatographic assay (LFIA) test kit for the measurement of anti-PA IgG in serum or whole-blood samples (30-µl samples) using colloidal gold nanoparticles as the detection reagent and an internal control. Using sera from 19 anthrax AVA vaccinees (anti-PA IgG range, 2.4 to 340 µg/ml) and 10 controls and PA-supplemented whole-blood samples, we demonstrated that the LFIA had a sensitivity of approximately 3 µg/ml anti-PA IgG in serum and ~14 µg/ml anti-PA IgG in whole blood. Preabsorption of sera with PA yielded negative anti-PA LFIAs. The diagnostic sensitivity and specificity of the assay were 100% using ELISA-measured anti-PA IgG as the standard. This kit has utility in determining anti-PA antibody reactivity in the sera of individuals vaccinated with AVA or individuals with clinical anthrax.
KW - anthrax
KW - blood
KW - blood serum
KW - cell culture vaccines
KW - diagnostic techniques
KW - human diseases
KW - IgG
KW - immunodiagnosis
KW - immunological techniques
KW - protective antigens
KW - Indiana
KW - USA
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - bacterium
KW - immunochromatographic test
KW - serological diagnosis
KW - serological techniques
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063107749&site=ehost-live&scope=site
UR - email: rbiagini@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building.
AU - Park, J. H.
AU - Cox-Ganser, J.
AU - Rao, C.
AU - Kreiss, K.
JO - Indoor Air
JF - Indoor Air
Y1 - 2006///
VL - 16
IS - 3
SP - 192
EP - 203
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0905-6947
AD - Park, J. H.: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies MS 2800 1095, Field Studies Branch, Willowdale Road, Morgantown WV 26505, USA.
N1 - Accession Number: 20063228499. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - We investigated the associations of fungal and endotoxin levels in office dust with respiratory health in 888 (67% participation) occupants of a water-damaged building. The study building is a large 20-story office building constructed in 1985 and located in a metropolitan area in the north-east USA. We analysed floor and chair dusts from 338 workstations for culturable fungi and endotoxin. Based on averages, we ranked each floor of the building as low, medium, or high for occupants' exposure to each of these agents. Multivariate logistic regression models for building-related symptoms included this ranking of fungi and endotoxin, age, gender, race, smoking status, and duration of occupancy. Using floor dust measures, we found significantly increased odds for lower respiratory symptoms (wheeze, chest tightness, attacks of shortness of breath, and attacks of cough: odds ratios (OR)=1.7 (95% confidence interval (CI): 1.02-2.77) to 2.4 (95% CI: 1.29-4.59)), throat irritation (OR=1.7, (95% CI: 1.06-2.82)), and rash/itchy skin (OR=3.0, (95% CI: 1.47-6.19)) in the highest fungal exposure group compared to the lowest, with generally linear exposure-response relationships. Nonlinear relationships were observed for many of these symptoms and endotoxin in floor dust. Interaction models showed that endotoxin modified effects of fungi on respiratory symptoms. Our findings of exposure interactions and exposure-response relationships of fungal and endotoxin with increased risk of building-related symptoms contribute to an understanding of the role of microbial agents in building-related asthma and respiratory and systemic symptoms.
KW - asthma
KW - buildings
KW - cough
KW - dust
KW - endotoxins
KW - exposure
KW - human diseases
KW - lungs
KW - respiratory diseases
KW - USA
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Biodegradation (XX700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063228499&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-0668.2005.00415.x
UR - email: gzp8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perceived discrimination in health care among American Indians/Alaska Natives.
AU - Johansson, P.
AU - Jacobsen, C.
AU - Buchwald, D.
JO - Ethnicity & Disease
JF - Ethnicity & Disease
Y1 - 2006///
VL - 16
IS - 4
SP - 766
EP - 771
CY - Georgia; USA
PB - International Society on Hypertension in Blacks
SN - 1049-510X
AD - Johansson, P.: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093019983. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Objectives: We compared the prevalence of, and reasons for, perceived discrimination in health care among American Indian/Alaska Natives (AI/ANs) and persons of AI/AN+White heritage to African Americans, Asian Americans, and Whites. Design: Data on perceived discrimination were collected by the 2001 California Health Interview Survey (CHIS). We used chi-square tests to evaluate the prevalence of perceived discrimination and the reasons for perceived discrimination across racial groups. Setting: The 2001 CHIS, a telephone survey, one of the largest cross-sectional surveys ever conducted in the United States. Participants: Participants in this analysis were adults ≥18 years of age, interviewed from 55,000 households that took part in the survey. Interventions: Participants in the 2001 CHIS were asked "Thinking of your experiences with receiving health care in the past 12 months, have you felt you were discriminated against for any reason?" Respondents who endorsed this item were asked about possible reasons for the discrimination. Main Outcome Measures: (1) Does the prevalence of perceived discrimination in health care differ between AI/ANs, AI/AN+Whites, African Americans, Asian Americans, and Whites? and (2) Do the reasons for perceived discrimination in health care vary by race or ethnicity? Results: Discrimination was perceived by 7.1% of the AI/AN alone group, 8.8% of AI/AN+White respondents, 5.6% of African Americans, 4.3% of Whites, and 2.6% of Asian Americans. After adjusting for covariates, the odds of perceived discrimination were different for AI/AN+White (odds ratio [OR]=2.0, 95% confidence interval [CI] 1.5-2.5) and Asian American (OR=.5, 95% CI .4-.7) when compared to Whites. Conclusions: AI/ANs, and especially those who identify as AI/AN+White, were the most likely among racial groups to report discrimination in health care.
KW - American indians
KW - discrimination
KW - ethnic groups
KW - ethnicity
KW - health care
KW - Inuit
KW - minorities
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Eskimos
KW - ethnic differences
KW - United States of America
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093019983&site=ehost-live&scope=site
UR - http://www.ishib.org/ED/journal/16-4/ethn-16-04-766.pdf
UR - email: pjohansson@dc.doctorscommunity.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A comparison of variability in Papanicolaou and liquid-based cytology inadequacy rates using Shewhart control charts.
AU - Fox, R.
AU - Nix, A. B. J.
AU - Fielder, H.
JO - Cytopathology
JF - Cytopathology
Y1 - 2006///
VL - 17
IS - 4
SP - 175
EP - 181
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0956-5507
AD - Fox, R.: National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, UK.
N1 - Accession Number: 20073065435. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - Objective: To use Shewhart control charts to compare variability in inadequacy rates from Papanicolaou (Pap) and liquid-based cytology (LBC). Design: Retrospective analysis of quality assurance data. Setting: Eleven Welsh cytology laboratories. Methods: Shewhart 'p' charts were plotted for proportions of slides reported as inadequate. Charts were compared for statistical control. Main outcome measures: Evidence of statistical control in the processes. Results: Control charts allowed easy interpretation of patterns in the data. Variability in inadequacy rates was much lower for LBC than for Pap cytology. Conclusion: Monitoring inadequate rates with Shewhart charts provides more information than tabular monitoring reports, assisting in quality improvement. With respect to inadequacy rates, LBC is less variable than Pap cytology.
KW - cervix
KW - cytology
KW - Papanicolaou testing
KW - screening
KW - smears
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cervical smear
KW - screening tests
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073065435&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2303.2006.00302.x
UR - email: rosemary.fox@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterisation of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC-MS and NMR.
AU - Sundaresan, P. R.
AU - Slavoff, S. A.
AU - Grundel, E.
AU - White, K. D.
AU - Mazzola, E.
AU - Koblenz, D.
AU - Rader, J. I.
JO - Phytochemical Analysis
JF - Phytochemical Analysis
Y1 - 2006///
VL - 17
IS - 4
SP - 243
EP - 250
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0958-0344
AD - Sundaresan, P. R.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063163723. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants; Ornamnental Horticulture
N2 - Teucrium species, such as germander, are rich in neo-clerodane diterpenoids and have been used in traditional folk medicine for their stimulant, diuretic, antipyretic and antiseptic properties. However, the furano neo-clerodane diterpenoids present in germander have been implicated in the in vivo hepatotoxicity of this botanical. In this study, authenticated germander (Teucrium chamaedrys L. and Teucrium canadense L.) was used as the source material. Methanol extracts of powdered plant material were prepared and analysed by HPLC using Synergi® Max-RP columns with monitoring at 220 nm. Limited amounts of teucrin A and other diterpenoid standards were analysed on a Synergi Max-RP column in order to determine their retention times and to generate calibration curves. The same standards were subjected to concurrent mass spectral analysis. Teucrin A and diterpenoids such as dihydroteugin, teuflin, teuflidin and teucvidin were tentatively identified in the plant extracts by HPLC-MS and 1H-NMR experiments. For the isolation of teucrium diterpenoids on a semipreparative scale, a solid-phase extraction method was developed for the first time using styrene divinylbenzene and strata-X sorbents for teucrin A and teuflin, respectively. Semi-preparative HPLC of the methanol extract of the powdered aerial parts of Teucrium plants was carried out on a semipreparative Synergi Max-RP column with photodiode array detection in order to confirm the identities of some diterpenoids by HPLC-MS and NMR.
KW - analytical methods
KW - chemical composition
KW - diterpenoids
KW - HPLC
KW - medicinal plants
KW - nuclear magnetic resonance
KW - phytochemicals
KW - plant composition
KW - plant extracts
KW - techniques
KW - traditional medicines
KW - Teucrium canadense
KW - Teucrium chamaedrys
KW - Teucrium
KW - Lamiaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - chemical constituents of plants
KW - drug plants
KW - high performance liquid chromatography
KW - medicinal herbs
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063163723&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com/journal/pca
UR - email: p.sundaresan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lessons learned from a population-based chlamydia screening pilot.
AU - Götz, H. M.
AU - Bergen, J. E. A. M. van
AU - Veldhuijzen, I. K.
AU - Hoebe, C. J. P. A.
AU - Broer, J.
AU - Coenen, A. J. J.
AU - Groot, F. de
AU - Verhooren, M. J. C.
AU - Schaik, D. T. van
AU - Richardus, J. H.
JO - International Journal of STD & AIDS
JF - International Journal of STD & AIDS
Y1 - 2006///
VL - 17
IS - 12
SP - 826
EP - 830
CY - London; UK
PB - Royal Society of Medicine Press Ltd
SN - 0956-4624
AD - Götz, H. M.: Department of Infectious Diseases, Municipal Public Health Service, (The National Institute for STD and AIDS Control in the Netherlands), PO Box 70032, 300 LP Rotterdam, Netherlands.
N1 - Accession Number: 20073024746. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - We evaluated process organization and response optimization in a home-based Chlamydia trachomatis (Ct) screening project in the Netherlands among 15- to 29-year-old women and men. The method used was computer-supported data flow, from population sampling to informing participants of the result. A new test kit or a letter reminded non-respondents after six weeks. Fifteen-year olds required parental consent. Urine arrived at the laboratory within 29 days from invitation, and four (1-11) days after collection, indicating good specimen quality. Test kits had a higher response than letters (15 versus 10%). Response in 15-year olds was 33%; with 2% Ct infected sexually active 15 year olds. In Conclusion, purpose made computer software is essential for an efficient screening programme. Sending urine by mail does not impair diagnostics. Reminders are necessary and effective after four weeks. Necessary parental consent for under 16-year olds should not be a deterrent to offer Ct screening to this age group.
KW - adults
KW - bacterial diseases
KW - human diseases
KW - screening
KW - sexual behaviour
KW - sexually transmitted diseases
KW - young adults
KW - Netherlands
KW - Chlamydia trachomatis
KW - man
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - screening tests
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - STDs
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073024746&site=ehost-live&scope=site
UR - http://www.rsmpress.co.uk/std.htm
UR - email: gotzh@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of estimated daily intake of nitrite by average consumption of processed foods in Korea.
AU - Lee ChangHee
AU - Cho YangHee
AU - Park KwanHwa
JO - Food Control
JF - Food Control
Y1 - 2006///
VL - 17
IS - 12
SP - 950
EP - 956
CY - Oxford; UK
PB - Elsevier
SN - 0956-7135
AD - Lee ChangHee: Busan Regional Food and Drug Administration, Busan 608-829, Korea Republic.
N1 - Accession Number: 20063148194. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Tropical Diseases
N2 - This study has been performed to estimate the average daily intake of nitrite used in Korea as a color fixative. The crude estimation of daily intake was calculated based on maximum permitted levels (MPL) and national food disappearance data in 1998. In order to refine estimated daily intake (EDI), daily food consumption nationwide National Health and Nutrition Survey in 1998 and the concentration of nitrite in their permitted foods were applied. The crude EDI of nitrite was 17.85 µg/kg bw/day, representing 25.5% of acceptable daily intake (ADI) assigned by JECFA. The refined average EDI for nitrite was 0.87 µg/kg bw/day, representing 1.25% of ADI. For average consumers of age-sex groups ranged from 0.2 to 4.8 µg/kg bw/day, representing 0.3%-6.9% of the ADI.
KW - diet
KW - food additives
KW - food colourants
KW - food consumption
KW - food safety
KW - nitrites
KW - nutrient intake
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - food colorants
KW - South Korea
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063148194&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09567135
UR - email: chlee65@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of treated and untreated depressive symptoms on highly active antiretroviral therapy use in a US multi-site cohort of HIV-positive women.
AU - Cook, J. A.
AU - Grey, D.
AU - Burke-Miller, J.
AU - Cohen, M. H.
AU - Anastos, K.
AU - Gandhi, M.
AU - Richardson, J.
AU - Wilson, T.
AU - Young, M.
JO - AIDS Care
JF - AIDS Care
Y1 - 2006///
VL - 18
IS - 2
SP - 93
EP - 100
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0954-0121
AD - Cook, J. A.: Center for Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL 60603, USA.
N1 - Accession Number: 20063045848. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5, 561-27-3. Subject Subsets: Public Health
N2 - This study examines the effects of treated and untreated depressive symptoms on the likelihood of utilization of highly active antiretroviral therapy (HAART) among a multi-site cohort of HIV-infected women who screened positive for probable depression. Data were collected biannually from 1996 through 2001 in a prospective cohort study. Random-effects regression analysis was used to estimate the longitudinal effects of mental health treatment on the probability of HAART utilization, controlling for clinical indicators (CD4 count, viral load), demographic features (race/ethnicity, income), and behavioural factors (recent crack, cocaine, or heroin use). Use of antidepressants plus mental health therapy, or use of mental health therapy alone significantly increased the probability of HAART utilization, compared to receiving no depression treatment. Use of antidepressants alone did not differ significantly from receiving no depression treatment. African American women and those who used crack, cocaine, or heroin also were less likely to use HAART. These findings suggest that efforts to enhance depressed women's access to psychopharmacologic treatment and therapy may increase their use of the most effective HIV therapies.
KW - antidepressants
KW - antiretroviral agents
KW - antiviral agents
KW - cocaine
KW - crack
KW - depression
KW - drug abuse
KW - drug therapy
KW - ethnic groups
KW - heroin
KW - highly active antiretroviral therapy
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - mental health
KW - symptoms
KW - women
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - African-Americans
KW - chemotherapy
KW - crack cocaine
KW - diacetylmorphine
KW - diamorphine
KW - drug use
KW - HAART
KW - Human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063045848&site=ehost-live&scope=site
UR - http://journalsonline.tandf.co.uk/link.asp?id=100631
UR - email: cook@ripco.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Progress in development of an integrated dietary supplement ingredient database at the NIH Office of Dietary Supplements.
AU - Dwyer, J. T.
AU - Picciano, M. F.
AU - Betz, J. M.
AU - Fisher, K. D.
AU - Saldanha, L. G.
AU - Yetley, E. A.
AU - Coates, P. M.
AU - Radimer, K.
AU - Bindewald, B.
AU - Sharpless, K. E.
AU - Holden, J.
AU - Andrews, K.
AU - Zhao, C. W.
AU - Harnly, J.
AU - Wolf, W. R.
AU - Perry, C. R.
A2 - Pennington, J. A. T.
A2 - Stumbo, P. J.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2006///
VL - 19
SP - S108
EP - S114
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Dwyer, J. T.: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063122125. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - Several activities of the Office of Dietary Supplements (ODS) at the National Institutes of Health involve enhancement of dietary supplement databases. These include an initiative with US Department of Agriculture to develop an analytically substantiated dietary supplement ingredient database (DSID) and collaboration with the National Center for Health Statistics to enhance the dietary supplement label database in the National Health and Nutrition Examination Survey (NHANES). The many challenges that must be dealt with in developing an analytically supported DSID include categorizing product types in the database, identifying nutrients, and other components of public health interest in these products and prioritizing which will be entered in the database first. Additional tasks include developing methods and reference materials for quantifying the constituents, finding qualified laboratories to measure the constituents, developing appropriate sample handling procedures, and finally developing representative sampling plans. Developing the NHANES dietary supplement label database has other challenges such as collecting information on dietary supplement use from NHANES respondents, constant updating and refining of information obtained, developing default values that can be used if the respondent cannot supply the exact supplement or strength that was consumed, and developing a publicly available label database. Federal partners and the research community are assisting in making an analytically supported dietary supplement database a reality.
KW - databases
KW - food composition
KW - food supplements
KW - information processing
KW - labelling
KW - nutrition
KW - data banks
KW - labeling
KW - labels
KW - Information and Documentation (CC300)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Composition and Quality (QQ500)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063122125&site=ehost-live&scope=site
UR - email: dwyerj1@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of baseline protease genotype and phenotype on HIV response to atazanavir/ritonavir in treatment-experienced patients.
AU - Naeger, L. K.
AU - Struble, K. A.
JO - AIDS
JF - AIDS
Y1 - 2006///
VL - 20
IS - 6
SP - 847
EP - 853
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Naeger, L. K.: Division of Antiviral Products, Center for New Drug Evaluation, Food and Drug Administration, 10903 New Hampshire Avenue, Building #22, Room 6367, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20063080337. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 198904-31-3, 192725-17-0, 155213-67-5. Subject Subsets: Public Health
N2 - Objectives: To assess the virologic response rates of atazanavir/ritonavir and lopinavir/ritonavir based on baseline genotype and phenotype. Methods: Resistance analyses were performed on a Bristol-Myers Squibb-sponsored study comparing the safety and efficacy of atazanavir/ritonavir to lopinavir/ritonavir in treatment-experienced subjects at 48 weeks. Analyses evaluated virologic response based on the presence of baseline primary protease inhibitor mutations and baseline susceptibility. Results: Less than 30% of atazanavir/ritonavir-treated patients were responders if substitutions at positions M46, G73, I84 or L90 were present in their HIV at baseline. In comparison, lopinavir/ritonavir response rates were less than 30% when protease substitutions at M46, I54, or I84 were present at baseline. The response rates were similar between atazanavir/ritonavir and lopinavir/ritonavir-treated subjects with zero to four baseline protease inhibitor mutations, but response rates were reduced if five or more baseline mutations were present: 0% for atazanavir/ritonavir compared with 28% for lopinavir/ritonavir. Baseline phenotype results showed that response rates were similar between atazanavir/ritonavir and lopinavir/ritonavir if shifts in susceptibility were zero to five, but response rates were lower if shifts were greater than five; 11% for atazanavir/ritonavir compared with 27% for lopinavir/ritonavir. Conclusions: Both type and number of baseline protease inhibitor mutations affected virologic response to atazanavir/ritonavir and lopinavir/ritonavir in treatment-experienced subjects. In addition, baseline phenotypic susceptibility could differentiate virologic response rates to the two drugs. These resistance analyses provide information on the likelihood of a virologic response to antiretroviral drugs based on baseline genotypic and phenotypic data, which is valuable to physicians and patients when choosing antiretroviral regimens.
KW - atazanavir
KW - drug therapy
KW - genotypes
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - lopinavir
KW - phenotypes
KW - ritonavir
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063080337&site=ehost-live&scope=site
UR - email: lisa.naeger@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Provider-specific report cards: a tool for health sector accountability in developing countries.
AU - McNamara, P.
JO - Health Policy and Planning
JF - Health Policy and Planning
Y1 - 2006///
VL - 21
IS - 2
SP - 101
EP - 109
CY - Oxford; UK
PB - Oxford University Press
SN - 0268-1080
AD - McNamara, P.: Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20063043095. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - In most health care systems in most countries, providers are not adequately held accountable - by governments, purchasers, provider professional associations or civil society - for the quality of care. One approach to improve provider accountability that is being debated and implemented in a subset of developed countries and a smaller group of developing countries is provider-specific comparative performance reporting. This review discusses universal design options for report cards, summarizes the evidence base, presents developing country examples, reviews challenges and outlines implementation steps. The ultimate aim is to provoke thoughtful debate about if and how comparative performance reporting fits within a developing country's broader framework of strategies to promote quality of care.
KW - accountability
KW - data collection
KW - health care workers
KW - records
KW - reviews
KW - Developing Countries
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - countries
KW - data logging
KW - Third World
KW - Underdeveloped Countries
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063043095&site=ehost-live&scope=site
UR - email: pmcnamar@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity.
AU - Murono, E. P.
AU - Derk, R. C.
AU - Akgul, Y.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2006///
VL - 21
IS - 2
SP - 148
EP - 153
CY - New York; USA
PB - Elsevier
SN - 0890-6238
AD - Murono, E. P.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20073009661. Publication Type: Journal Article. Language: English. Registry Number: 57-88-5, 72-43-5, 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8, 15262-86-9. Subject Subsets: Agricultural Entomology
N2 - Methoxychlor (MC) was developed as a replacement for the banned pesticide DDT. After in vivo administration, it is metabolized in the liver to 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which is proposed to be the active agent. Both MC and HPTE have been shown to exhibit weak estrogenic and antiandrogenic activities, and they are thought to exert their effects through oestrogen and androgen receptors, respectively. Although in vitro studies using cultured rat Leydig cells have reported that HPTE inhibits both basal and hCG-stimulated testosterone formation, the response of circulating testosterone levels to in vivo MC has been more variable. Therefore, the current studies evaluated whether the daily in vivo administration of MC (0, 5, 40 and 200 mg/kg body weight) for a short duration (days 54-60 of age) by gavage altered serum testosterone levels and ex vivo Leydig cell testosterone formation in young adult male rats. These results demonstrate that both fluid-retained and fluid-expressed seminal vesicle weights declined to 44 and 60% of control, respectively, in the 200 mg/kg MC-exposed animals. Similarly, serum testosterone and dehydroepiandrosterone levels declined to 41 and 45% of control, respectively, in the 200 mg/kg MC-exposed animals; however, serum LH and FSH levels were unaffected. Ex vivo Leydig cell basal testosterone formation over 4 h declined to 49% of control in animals exposed to 200 mg/kg MC, and ex vivo Leydig cell P450 cholesterol side-chain cleavage activity declined to 79 and 50% of control in animals exposed to 40 and 200 mg/kg of MC, respectively, supporting previous in vitro studies which demonstrated the sensitivity of this step to MC.
KW - androgens
KW - cholesterol
KW - insecticides
KW - methoxychlor
KW - oestrogens
KW - serum
KW - testosterone
KW - toxicity
KW - vesicular gland
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - estrogens
KW - seminal vesicle
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073009661&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TC0-4H9PN2K-1&_user=10&_handle=C-WA-A-AW-AW-MsSAYWA-UUW-U-U-AW-U-U-AADAZUBADY-AAZEAYBEDY-WWBCVWUVA-AW-U&_fmt=summary&_coverDate=02%2F28%2F2006&_rdoc=3&_orig=browse&_srch=%23toc%235156%232006%23999789997%23614969!&_cdi=5156&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ae83ea9e3019f863a7444cf5f936e6a6
UR - email: eem8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein.
AU - Doerge, D. R.
AU - Twaddle, N. C.
AU - Churchwell, M. I.
AU - Newbold, R. R.
AU - Delclos, K. B.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2006///
VL - 21
IS - 3
SP - 307
EP - 312
CY - New York; USA
PB - Elsevier
SN - 0890-6238
AD - Doerge, D. R.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073009646. Publication Type: Journal Article. Language: English. Registry Number: 446-72-0. Subject Subsets: Soyabeans; Human Nutrition; Dairy Science
N2 - Exposures of Sprague-Dawley rats to the soy isoflavone, genistein, throughout the entire lifespan have produced a number of effects on reproductive tissues, immune function, neuroendocrine function and behavior. Our previous studies investigated pharmacokinetics and disposition of genistein during adult and fetal periods and this study describes the internal exposures of post-natal day 10 (PND10) rat pups due to lactational transfer of genistein. Conjugated and aglycone forms of genistein were measured by using LC/MS/MS in serum (PND10) and milk (PND7) from lactating dams consuming a genistein-fortified soy-free diet, and in serum from their pups at a time when milk was the only food source (PND10). This study shows that limited lactational transfer of genistein to rat pups occurs and that internal exposures to the active aglycone form of genistein are generally lower than those measured previously in the fetal period. These results suggest that developmental effects attributable to genistein exposure in our chronic and multi-generation studies are more likely to result from fetal exposures because of the higher levels of the active estrogenic aglycone form of genistein in utero, although the possibility of neonatal responses cannot be excluded.
KW - animal models
KW - genistein
KW - isoflavones
KW - laboratory animals
KW - lactation
KW - lifespan
KW - pharmacokinetics
KW - soyabeans
KW - Glycine (Fabaceae)
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - aglycones
KW - biochanin A
KW - soybeans
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073009646&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TC0-4HF5KDM-1&_user=10&_handle=C-WA-A-WA-WA-MsSAYVA-UUW-U-U-WA-U-U-AADAZUBADW-AAZEAYBEDW-WWBCVAEZV-WA-U&_fmt=summary&_coverDate=04%2F30%2F2006&_rdoc=15&_orig=browse&_srch=%23toc%235156%232006%23999789996%23617650!&_cdi=5156&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e600eec9e1aa267b38ac518403cdc55b
UR - email: ddoerge@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nonfatal all-terrain vehicle-related injuries to youths living on farms in the United States, 2001.
AU - Goldcamp, E. M.
AU - Myers, J.
AU - Hendricks, K.
AU - Layne, L.
AU - Helmkamp, J.
JO - Journal of Rural Health
JF - Journal of Rural Health
Y1 - 2006///
VL - 22
IS - 4
SP - 308
EP - 313
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0890-765X
AD - Goldcamp, E. M.: Division of Safety Research, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 1808, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20063199891. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Leisure, Recreation, Tourism; Public Health; Agricultural Engineering
N2 - Purpose: To provide estimates of all-terrain vehicle (ATV) ownership and exposure on farms and an overview of injuries to youths as a result of ATV use on the farm in the USA, in 2001. Methods: The 2001 Childhood Agricultural Injury Survey data obtained for the National Institute for Occupational Safety and Health by the US Department of Agriculture were analysed. These data, collected via telephone surveys, provide information on nonfatal injuries that occurred to youths younger than 20 years living on farms. The injuries included both occupational and nonoccupational incidents. Findings: Of an estimated 1.1 million youths living on farms, 36% had operated an ATV in 2001. Youths younger than 16 years old were more likely to have operated an ATV than a tractor on these farms. An estimated 2246 nonfatal ATV-related injuries occurred to youths younger than 20 years. The majority of these ATV injuries (n=1668, 74%) occurred in youths identified as members of the household. Males accounted for 1145 (69%) of the ATV injuries to household youths. Majority of the injuries occurred in those aged 10-15 years (n=1170, 70%). Most ATV injuries were the result of recreational activities (n=970, 58%). In addition, many of these injury events involved youths riding without helmets and using ATVs that were larger than the recommended size for their age. Conclusion: ATV-related injuries to household youths are prevalent on farms.
KW - accidents
KW - epidemiology
KW - farms
KW - occupational hazards
KW - occupational health
KW - recreational activities
KW - rural areas
KW - trauma
KW - vehicles
KW - young workers
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - traumas
KW - United States of America
KW - youth employment
KW - Sport and Recreational Activities (UU625) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Agricultural and Forestry Equipment (General) (NN400)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063199891&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jrh
UR - email: ehg8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Early detection and primary prevention of type 2 diabetes: what's happening in your locality?
AU - John, A.
AU - Williams, R.
AU - Lloyd, B.
AU - Gunneburg, A.
T2 - Practical Diabetes International
JO - Practical Diabetes International
JF - Practical Diabetes International
Y1 - 2006///
VL - 23
IS - 4
SP - 157
EP - 160
CY - Chichester; UK
PB - John Wiley & Sons Ltd
SN - 1357-8170
AD - John, A.: Registrar in Public Health, National Public Health Service for Wales of Medicine, University of Wales, Swansea, Singleton Park, Swansea SA2 8PP, UK.
N1 - Accession Number: 20073148641. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition
N2 - Activities relating to the early detection and primary prevention of type 2 diabetes are likely to vary widely. This study used a telephone questionnaire to determine current practice in primary care in one locality in the UK. Validation of practice responses was performed by a separate analysis of biochemistry laboratory records. A 100% response rate was obtained. For 31 (86%) practices, this information was obtained from the lead GP. Nine (25%) practices operated no system for identifying those at risk of developing type 2 diabetes, 15 (42%) did so opportunistically, three (8%) issued invitations to come in and be tested, and nine (25%) did both. A patient with a negative test would be followed up annually by 17/27 (63%) practices; the rest operated no formal arrangements for a repeat test. There was a significantly higher mean number of glucose tests requested in those practices using both opportunistic identification and invitations than those with no active identification (mean number of glucoses requested per 1000 population=205 (±SEM 17) vs. 149 (±SEM 16)). Current primary care activities in the early identification and prevention of type 2 diabetes show considerable variation between practices and some deviation from current recommendations which are, in general, consensus, not evidence-based. The most active practices requested significantly higher numbers of glucose tests compared with the least active, providing some validation of the responses obtained. The development and effective dissemination of evidence-based guidelines, as well as making available service development monies, may go some way to addressing these issues.
KW - diabetes mellitus
KW - disease prevention
KW - early diagnosis
KW - human diseases
KW - primary health care
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - type 2 diabetes mellitus
KW - United Kingdom
KW - Health Services (UU350)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073148641&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/jhome/70003726
UR - email: A.John@swansea.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Correlates of public health workforce acceptance of smallpox immunization in Virginia.
AU - Bryant-Genevier, M.
AU - Sommer, S.
AU - McMahon, A.
AU - Ball, R.
AU - Braun, M.
JO - Public Health Nursing
JF - Public Health Nursing
Y1 - 2006///
VL - 23
IS - 4
SP - 339
EP - 346
CY - Boston; USA
PB - Blackwell Publishing
SN - 0737-1209
AD - Bryant-Genevier, M.: CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Suite 268 S, HFM-222, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20073065342. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - Objective: By October 24, 2003, 38, 77 of 500 000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Design: Cross-sectional survey, conducted in May 2004. Sample: We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Results: Among nonvaccinees (n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees (n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6-85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1-22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6-81.1). Conclusion: Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed.
KW - attitudes
KW - bioterrorism
KW - health care workers
KW - human diseases
KW - immunization
KW - medical auxiliaries
KW - occupational hazards
KW - occupational health
KW - smallpox
KW - vaccination
KW - USA
KW - Virginia
KW - man
KW - Variola virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - allied health occupations
KW - health workers
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073065342&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=phn
UR - email: marthe.bryant-genevier@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro antimicrobial susceptibility, genetic diversity and prevalence of UDP-glucose 4-epimerase (galE) gene in Campylobacter coli and Campylobacter jejuni from Turkey production facilities.
AU - Nayak, R.
AU - Stewart, T.
AU - Nawaz, M.
AU - Cerniglia, C.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006///
VL - 23
IS - 4
SP - 379
EP - 392
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Nayak, R.: US Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063088888. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 1405-87-4, 56-75-7, 85721-33-1, 1403-66-3, 1405-41-0, 8063-07-8, 389-08-2, 57-92-1, 723-46-6, 738-70-5, 69-52-3, 69-53-4, 7177-48-2. Subject Subsets: Poultry; Human Nutrition
N2 - This study evaluated the genetic diversity of multi-drug resistant Campylobacter jejuni (n=44) and C. coli (n=30) isolated from 18 turkey houses. Antimicrobial resistances to ampicillin, ciprofloxacin and nalidixic acid were higher (P<0.05) in C. coli than in C. jejuni strains. PCR analysis indicated that 82% of total isolates tested, including 91% of C. jejuni and 70% of C. coli tested positive for a 496-bp UDP-glucose 4-epimerase (galE) gene. The diversity of isolates was mapped by antibiogram, SmaI-PFGE and flaA-RFLP typing methods using the discriminatory index (DI). RFLP was more suitable in discriminating C. coli (DI=0.895) than PFGE (DI=0.816) or antibiogram profile (DI=0.552), while either PFGE (DI=0.941) or RFLP (DI=0.942) could be used in discriminating C. jejuni strains. The combined PFGE and antibiogram dendrogram had the highest DI for both C. coli (0.910) and C. jejuni (0.968), suggesting that a combination of typing methods is more useful in examining the diverse Campylobacter population on turkey farms.
KW - ampicillin
KW - antibacterial agents
KW - bacitracin
KW - chloramphenicol
KW - ciprofloxacin
KW - gene expression
KW - genes
KW - genetic diversity
KW - genotypes
KW - gentamicin
KW - in vitro
KW - kanamycin
KW - molecular epidemiology
KW - molecular genetics
KW - multiple drug resistance
KW - nalidixic acid
KW - poultry
KW - streptomycin
KW - sulfamethoxazole
KW - trimethoprim
KW - Arkansas
KW - USA
KW - Campylobacter coli
KW - Campylobacter jejuni
KW - turkeys
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Meleagris
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West South Central States of USA
KW - bacterium
KW - biochemical genetics
KW - domesticated birds
KW - sulphamethoxazole
KW - UDP-glucose 4-epimerase
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063088888&site=ehost-live&scope=site
UR - email: rnayak@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Moulds and yeasts in fruit salads and fruit juices.
AU - Tournas, V. H.
AU - Heeres, J.
AU - Burgess, L.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006///
VL - 23
IS - 7
SP - 684
EP - 688
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition (HFS-315), Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063138709. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Soyabeans; Human Nutrition; Medical & Veterinary Mycology; Dairy Science
N2 - Thirty-eight fruit salad samples including cantaloupe, citrus fruits, honeydew, pineapple, cut strawberries and mixed fruit salads, and 65 pasteurized fruit juice samples (apple, carrot, grapefruit, grape and orange juices, apple cider, and soy milk) were purchased from local supermarkets in the Washington, DC area and tested for fungal contamination. The majority of fruit salad samples (97%) were contaminated with yeasts at levels ranging from <2.0 to 9.72 log10 of colony forming units per gram (cfu/g). Frequently encountered yeasts were Pichia spp., Candida pulcherrima, C. lambica, C. sake, Rhodotorula spp., and Debaryomyces polymorphus. Low numbers of Penicillium spp. were found in pineapple salads, whereas Cladosporium spp. were present in mixed fruit and cut strawberry salads. Twenty-two per cent of the fruit juice samples tested showed fungal contamination. Yeasts were the predominant contaminants ranging from <1.0 to 6.83 log10 cfu/ml. Yeasts commonly found in fruit juices were C. lambica, C. sake, and Rhodotorula rubra. Geotrichum spp. and low numbers of Penicillium and Fusarium spp. (1.70 and 1.60 log10 cfu/ml, respectively) were present in grapefruit juice.
KW - apple juice
KW - carrot juice
KW - citrus fruits
KW - food contamination
KW - fruit juices
KW - grapefruit juice
KW - honeydew
KW - melons
KW - microbial contamination
KW - moulds
KW - orange juice
KW - pineapples
KW - salads
KW - soya milk
KW - strawberries
KW - yeasts
KW - USA
KW - Ananas comosus
KW - Candida
KW - Cladosporium
KW - Cucumis melo
KW - Debaryomyces
KW - Fragaria
KW - Fusarium
KW - Geotrichum
KW - Penicillium
KW - Pichia
KW - Rhodotorula
KW - Rhodotorula mucilaginosa
KW - Saccharomycetaceae
KW - fungi
KW - eukaryotes
KW - Ananas
KW - Bromeliaceae
KW - Bromeliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - Rosaceae
KW - Rosales
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Dipodascaceae
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pichiaceae
KW - Sporidiobolales
KW - Microbotryomycetes
KW - Pucciniomycotina
KW - Basidiomycota
KW - Rhodotorula
KW - Candida
KW - Debaryomyces
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Candida lambica
KW - Candida pulcherrima
KW - Candida sake
KW - Debaryomyces polymorphus
KW - food contaminants
KW - fungus
KW - Hyphomycetes
KW - molds
KW - Rhodotorula rubra
KW - soy milk
KW - soyabean milk
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063138709&site=ehost-live&scope=site
UR - email: vtournas@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diffusion of limonene in polyethylene.
AU - Limm, W.
AU - Begley, T. H.
AU - Lickly, T.
AU - Hentges, S. G.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2006///
VL - 23
IS - 7
SP - 738
EP - 746
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Limm, W.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration (HFS-245), 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063143739. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 138-86-3, 9002-88-4.
N2 - Diffusion coefficients of limonene in various linear low-density polyethylene (LLDPE) and low-density polyethylene (LDPE) resins have been determined from sorption data using a thermogravimetric methodology. From these data, one can determine whether polymer synthesis parameters such as the choice of catalytic process or co-monomer result in substantial differences in how much food packaging additives might migrate to food. For example, LLDPE is currently manufactured using either one of two distinct catalytic processes: Ziegler-Natta (ZN) and metallocene, a single-site catalyst. ZN catalysis is a heterogeneous process that has dominated polyolefin synthesis over the last half-century. It involves a transition metal compound containing a metal-carbon bond that can handle repeated insertion of olefin units. In contrast, metallocene catalysis has fewer than 20 years of history, but has generated much interest due to its ability to produce highly stereospecific polymers at a very high yield. In addition to high stereospecificity, metallocene-catalysed polymers are significantly lower in polydispersity than traditional ZN counterparts. Absorption and desorption testing of heat-pressed films made from LLDPE and LDPE resins of varying processing parameters indicates that diffusion coefficients of limonene in these resins do not change substantially.
KW - absorption
KW - catalysts
KW - catalytic activity
KW - desorption
KW - diffusion
KW - diffusivity
KW - food packaging
KW - food safety
KW - limonene
KW - methodology
KW - polyethylene
KW - diffusion coefficient
KW - methods
KW - polythene
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Chemistry (QQ600) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063143739&site=ehost-live&scope=site
UR - email: william.limm@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), aloe vera.
AU - Boudreau, M. D.
AU - Beland, F. A.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2006///
VL - 24
IS - 1
SP - 103
EP - 154
CY - Washington; USA
PB - Taylor & Francis
SN - 1059-0501
AD - Boudreau, M. D.: National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20063181840. Publication Type: Journal Article. Language: English. Number of References: 257 ref. Subject Subsets: Public Health; Aromatic & Medicinal Plants
N2 - Aloe barbadensis (Miller), Aloe vera, has a long history of use as a topical and oral therapeutic. The plant is the source of two products, gel and latex, which are obtained from its fleshy leaves. Aloe vera products contain multiple constituents with potential biological and toxicological activities, yet the active components elude definition. Ingestion of Aloe vera is associated with diarrhoea, electrolyte imbalance, kidney dysfunction, and conventional drug interactions; episodes of contact dermatitis, erythema, and phototoxicity have been reported from topical applications. This review examines the botany, physical and chemical properties, and biological activities of the Aloe vera plant.
KW - alternative medicine
KW - biological activity
KW - botany
KW - chemical properties
KW - contact dermatitis
KW - diarrhoea
KW - gels
KW - human diseases
KW - ingestion
KW - kidney diseases
KW - latex
KW - leaves
KW - phototoxicity
KW - physical properties
KW - plant products
KW - reviews
KW - toxicity
KW - Aloe vera
KW - man
KW - Aloe
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Aloaceae
KW - bioactivity
KW - crop products
KW - diarrhea
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - scouring
KW - Non-food/Non-feed Plant Products (SS200)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063181840&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=107845
UR - email: mary.boudreau@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Obstacles and advances in SARS vaccine development.
AU - Taylor, D. R.
JO - Vaccine
JF - Vaccine
Y1 - 2006///
VL - 24
IS - 7
SP - 863
EP - 871
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Taylor, D. R.: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration, 8800 Rockville Pike, HFM-310, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063051001. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Subject Subsets: Public Health
N2 - The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.
KW - candidate vaccines
KW - DNA vaccines
KW - human diseases
KW - immunization
KW - molecular biology
KW - pathogenesis
KW - respiratory diseases
KW - reviews
KW - severe acute respiratory syndrome
KW - vaccination
KW - vaccine development
KW - viral diseases
KW - Coronaviridae
KW - man
KW - Nidovirales
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Coronavirus
KW - Coronaviridae
KW - immune sensitization
KW - lung diseases
KW - SARS
KW - SARS coronavirus
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063051001&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: taylord@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains.
AU - Rubin, S.
AU - Mauldin, J.
AU - Chumakov, K.
AU - Vanderzanden, J.
AU - Iskow, R.
AU - Carbone, K.
JO - Vaccine
JF - Vaccine
Y1 - 2006///
VL - 24
IS - 14
SP - 2662
EP - 2668
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Rubin, S.: Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063059487. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9001-67-6. Subject Subsets: Public Health
N2 - The recent resurgence of mumps epidemics in many countries with ongoing vaccination programs along with evidence of antigenic diversity among mumps virus strains have recently challenged the assumption that mumps virus is serologically monotypic. To address this controversy, we sought to identify two mumps virus strains that would best represent different serotypes, should multiple serotypes exist, and assess the ability of human sera to neutralize both strains. The virus strains, Enders and Lo1, were selected based upon a phylogenetic analysis of the major target of neutralizing antibody, the viral hemagglutinin-neuraminidase (HN) protein, along with data reported by others indicating that (1) these viruses are antigenically distinct and (2) genotypically similar strains have been implicated in cases of reinfection. Our results show that of sera capable of neutralizing one of the virus strains, 90% could neutralize the other, although significant differences in neutralization titers were noted. Though the latter confirms the existence of inter-strain antigenic variability, the fact that few sera were unable to neutralize both virus strains argues against the presence of multiple serotypes. Of those sera incapable of co-neutralization, all but one had low neutralization titers (1:8), suggesting that individuals possessing low levels of neutralizing antibody may be at risk for breakthrough infections, thereby providing an explanation for cases of infection in previously infected or vaccinated individuals.
KW - epidemics
KW - epidemiology
KW - haemagglutinins
KW - human diseases
KW - immune response
KW - immunity
KW - immunization
KW - immunization programmes
KW - mumps
KW - neutralizing antibodies
KW - reinfection
KW - serotypes
KW - sialidase
KW - vaccination
KW - man
KW - Mumps virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - exo-alpha-sialidase
KW - hemagglutinins
KW - immune sensitization
KW - immunity reactions
KW - immunization programs
KW - immunological reactions
KW - neuraminidase
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063059487&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: rubins@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse events after hepatitis A B combination vaccine.
AU - Woo, E. J.
AU - Miller, N. B.
AU - Ball, R.
JO - Vaccine
JF - Vaccine
Y1 - 2006///
VL - 24
IS - 14
SP - 2685
EP - 2691
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Woo, E. J.: Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20063059489. Publication Type: Journal Article. Corporate Author: USA, VAERS Working Group Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - In May 2001, the U.S. Food and Drug Administration (FDA) approved Hepatitis A Inactivated and Hepatitis B Recombinant Vaccine (HEPAB) for immunization of adults. From May 2001 to September 2003, the Vaccine Adverse Event Reporting System (VAERS) received 305 reports of adverse events after HEPAB. Many events were similar to those reported after the monovalent hepatitis A and B vaccines. Non-serious events included constitutional symptoms and local reactions. Serious events included neurologic, hepatobiliary, and dermatologic conditions, and detailed medical and epidemiological review did not suggest a clear pattern of evidence supporting a causal relationship with the vaccine, except for injection site reactions and some allergic reactions.
KW - adverse effects
KW - allergies
KW - epidemiology
KW - hepatitis A
KW - hepatitis B
KW - human diseases
KW - immunization
KW - recombinant vaccines
KW - vaccination
KW - USA
KW - Hepatitis A virus
KW - Hepatitis B virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063059489&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: wooj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Passive surveillance for generalized vaccinia in the United States using the Vaccine Adverse Event Reporting System (VAERS).
AU - Bryant-Genevier, M.
AU - O'Connell, K.
AU - Ball, R.
AU - Braun, M. M.
AU - McMahon, A.
JO - Vaccine
JF - Vaccine
Y1 - 2006///
VL - 24
IS - 17
SP - 3632
EP - 3635
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Bryant-Genevier, M.: CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20063081261. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - Background: Generalized vaccinia (GV) is an adverse event specifically associated with smallpox vaccination, but shares clinical features with many common non-vaccine related rashes. We assessed the utility of passive reporting for GV surveillance by reviewing all Vaccine Adverse Event Reporting System (VAERS) reports of any post-smallpox vaccination rash in civilians and military personnel. Methods: We reviewed all reports submitted to VAERS between 12/12/2002 and 3/1 2004 for post-smallpox vaccine (SPV) rashes concerning civilians and military personnel. We evaluated the information contained in the reports independent of VAERS adverse event coding (GV or not GV). We classified the rash reports based on the recently published GV case definition from the Centers for Disease Control and Prevention. Results: Of the 936 rash reports after SPV, 92 were coded as GV. We classified 12 of the 92 as probable GV, and 1 as confirmed GV (14% probable or confirmed). Among the 844 reports not coded as GV, we classified 32 as either probable or confirmed GV (4%). Probable or confirmed reports that were coded as GV were similar to probable or confirmed reports not coded as GV with respect to demographic characteristics of the report subjects, and the location and phenotype (e.g., pustular, vesicular, etc.) of the rashes. Conclusions: A prospective study that applies well-defined clinical, histopathological, and laboratory criteria to smallpox-vaccinated patients with rashes would be necessary to distinguish GV from common alternative diagnoses with which it is easily confused.
KW - adverse effects
KW - data collection
KW - generalized infections
KW - human diseases
KW - immunization
KW - military personnel
KW - smallpox
KW - surveillance
KW - vaccination
KW - viral diseases
KW - USA
KW - man
KW - Vaccinia virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - data logging
KW - immune sensitization
KW - rashes
KW - United States of America
KW - vaccinia
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063081261&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: bryant-genevier@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance of influenza immunisation uptake in people aged under 65 years with chronic disease.
AU - Thomas, D. R.
AU - Mason, B. W.
AU - Beer, L.
AU - Scourfield, S.
AU - James-Hatherill, H.
AU - Hayes, S.
JO - Vaccine
JF - Vaccine
Y1 - 2006///
VL - 24
IS - 49/50
SP - 7027
EP - 7029
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Thomas, D. R.: National Public Health Service for Wales Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20063226429. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health
N2 - Historically, it has been difficult to obtain population based data on the uptake of influenza immunisation in people aged under 65 years who are at risk of serious illness or death from influenza and its complications. Data obtained electronically from 96% of all practices in Wales demonstrated that uptake in this group is low, with only a quarter of eligible patients immunised. Uptake varies considerably between patient groups and between geographical areas. This suggests an opportunity for significant health gain from targeted interventions to improve uptake.
KW - disease prevention
KW - elderly
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - vaccination
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - aged
KW - Britain
KW - elderly people
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - older adults
KW - senior citizens
KW - United Kingdom
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063226429&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: brendan.mason@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Population-based incidence of infection with selected bacterial enteric pathogens in children younger than five years of age, 1996-1998.
AU - Koehler, K. M.
AU - Lasky, T.
AU - Fein, S. B.
AU - DeLong, S. M.
AU - Hawkins, M. A.
AU - Rabatsky-Ehr, T.
AU - Ray, S. M.
AU - Shiferaw, B.
AU - Swanson, E.
AU - Vugia, D. J.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2006///
VL - 25
IS - 2
SP - 129
EP - 134
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Koehler, K. M.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20063071970. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - Background: Previous studies of bacterial enteric infections have suggested a disproportionate disease burden for children younger than 5 years of age. Objectives: This study describes population-based incidence of culture-confirmed infections with 6 bacterial enteric pathogens in children younger than 5 years of age in the Foodborne Diseases Active Surveillance Network (FoodNet), 1996-1998. Methods: Cases were ascertained through active laboratory-based surveillance in Minnesota, Oregon and selected counties in California, Connecticut, Georgia, Maryland and New York. Results: Twenty-one percent (5218 of 24,358) of infections were in children younger than 5 years of age, but this age group made up only 7% of the total person-years of observation. Among those younger than 5 years of age, the incidence (cases per 100,000 person-years) for each pathogen was: Salmonella, 55.3; Campylobacter, 43.4; Shigella, 32.7; E. coli O157, 10.3; Yersinia enterocolitica, 7.1; Listeria monocytogenes, 0.7. Incidence varied widely among the 7 FoodNet sites. Conclusions: This study confirmed a disproportionate disease burden in young children. Investigation of risk factors specific to this age group and review and enhancement of current prevention and control strategies for children younger than 5 years of age may reduce illness.
KW - age groups
KW - bacterial diseases
KW - children
KW - disease incidence
KW - disease surveys
KW - epidemiology
KW - human diseases
KW - pathogens
KW - California
KW - Connecticut
KW - Georgia
KW - Maryland
KW - Minnesota
KW - New York
KW - Oregon
KW - USA
KW - Campylobacter
KW - Escherichia coli
KW - Listeria monocytogenes
KW - man
KW - Salmonella
KW - Shigella
KW - Yersinia enterocolitica
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Yersinia (Bacteria)
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - New England States of USA
KW - Northeastern States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Southeastern States of USA
KW - Lake States of USA
KW - North Central States of USA
KW - West North Central States of USA
KW - Middle Atlantic States of USA
KW - Pacific Northwest States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - disease surveillance
KW - E. coli
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063071970&site=ehost-live&scope=site
UR - email: kathleen.koehler@hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced clinical utility of the NucliSens EasyQ RSV A+B Assay for rapid detection of respiratory syncytial virus in clinical samples.
AU - Moore, C.
AU - Valappil, M.
AU - Corden, S.
AU - Westmoreland, D.
JO - European Journal of Clinical Microbiology & Infectious Diseases
JF - European Journal of Clinical Microbiology & Infectious Diseases
Y1 - 2006///
VL - 25
IS - 3
SP - 167
EP - 174
CY - Berlin; Germany
PB - Springer-Verlag GmbH
SN - 0934-9723
AD - Moore, C.: Wales Specialist Virology Centre, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff, CF, 14 4XW, UK.
N1 - Accession Number: 20063114435. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - The aim of the present study was to compare traditional methods for the detection of respiratory syncytial virus with a newly developed commercial assay based on real-time nucleic acid sequence based amplification. Respiratory syncytial virus is a major cause of severe respiratory infection in infants and in certain groups of older children and adults. Treatment options are limited, but a rapid diagnosis improves patient management and infection control. The rapid diagnosis of respiratory syncytial virus currently relies on antigen detection assays. These tests are limited to use in certain good-quality types of samples, which are rarely obtained from adult patients. Molecular-based assays for the detection of respiratory syncytial virus are shown to be highly sensitive, specific, and more rapid than cell culture techniques. This retrospective study compared traditional laboratory techniques for the detection of respiratory syncytial virus in 508 respiratory samples collected during the winter months of 2003-2004 against the recently developed, commercially available NucliSens EasyQ Respiratory Syncytial Virus A+B assay (bioMérieux, Marcy l'Etoile, France), which is based on real-time nucleic acid sequence based amplification using molecular beacons and an internal control. Using traditional techniques, the prevalence of respiratory syncytial virus in the samples tested was found to be 21%. Using the real-time nucleic acid sequence-based amplification assay, an additional 41 samples from patients with a clinically diagnosed respiratory illness were found to be positive for respiratory syncytial virus. The NucliSens EasyQ assay was shown to be sensitive and specific for the detection of respiratory syncytial virus A+B in different types of respiratory samples. Moreover, the time required to complete the assay was <4 h, so results could be obtained on the same day as sample receipt in the laboratory.
KW - adults
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - nucleotide sequences
KW - respiratory diseases
KW - UK
KW - Human respiratory syncytial virus
KW - man
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - DNA sequences
KW - lung diseases
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063114435&site=ehost-live&scope=site
UR - email: catherine.moore@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid benefit-risk assessments: no escape from expert judgments in risk management.
AU - Claycamp, H. G.
JO - Risk Analysis
JF - Risk Analysis
Y1 - 2006///
VL - 26
IS - 1
SP - 147
EP - 156
CY - Boston; USA
PB - Blackwell Publishing
SN - 0272-4332
AD - Claycamp, H. G.: Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Pl., HFV-102, Rockville, MD 20855, USA.
N1 - Accession Number: 20063056900. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 93106-60-6. Subject Subsets: Veterinary Science; Poultry; Veterinary Science; Public Health
N2 - The "human health impacts assessment" described by Cox and Popken (this issue) is intended to be a benefit-risk tool that avoids pitfalls of using expert judgments for policy analysis or during strict application of the precautionary principle in risk management. The proposed benefit-risk calculation uses numerous assumptions and suppositions to calculate a ratio of quality-adjusted life years (QALYs) lost for the number of human illness days prevented by the use of a food-animal antimicrobial drug, to the number of human illness days caused by the use of the antimicrobial drug. Assumptions about data - e.g., expert judgments on the representativeness of parameter estimates - are commonly used in risk assessment and risk management, including Cox and Popken's method. Cox and Popken apply the technique to specific examples of enrofloxacin and macrolides antimicrobial drugs, sometimes used in broiler chickens for human food. Although enthusiastically portrayed as a straightforward calculation of QALYs lost for two decision alternatives, Cox and Popken were silent on the pivotal expert judgment subsumed in their method: quality weights for illnesses caused by antimicrobial-resistant and antimicrobial-sensitive microbes are tacitly assumed to be equal. Yet, the costs in terms of prolonged illness, additional medications, repeat medical visits, and dread of more serious sequelae are expected to differ substantially for antimicrobial-resistant versus antimicrobial-sensitive illnesses. Despite their enthusiasm to the contrary, the "human health impacts assessment" by Cox and Popken is not immune from expert judgments in risk management.
KW - antibacterial agents
KW - antibiotics
KW - broilers
KW - campylobacteriosis
KW - chicken meat
KW - costs
KW - drug resistance
KW - drug therapy
KW - enrofloxacin
KW - foodborne diseases
KW - human diseases
KW - illness
KW - macrolide antibiotics
KW - mathematical models
KW - meat animals
KW - poultry
KW - quality of life
KW - risk assessment
KW - statistical analysis
KW - zoonoses
KW - Campylobacter
KW - fowls
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - bacterium
KW - chemotherapy
KW - chickens
KW - costings
KW - domesticated birds
KW - risk management
KW - statistical methods
KW - zoonotic infections
KW - Health Economics (EE118) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Producing Animals (LL120)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063056900&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=risk
UR - email: hclaycam@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.
AU - Yucesoy, B.
AU - Peila, R.
AU - White, L. R.
AU - Wu, K. M.
AU - Johnson, V. J.
AU - Kashon, M. L.
AU - Luster, M. I.
AU - Launer, L. J.
JO - Neurobiology of Aging
JF - Neurobiology of Aging
Y1 - 2006///
VL - 27
IS - 2
SP - 211
EP - 217
CY - New York; USA
PB - Elsevier
SN - 0197-4580
AD - Yucesoy, B.: Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063098758. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1α, IL-1β and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n=931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1β (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1β (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1β (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia.
KW - dementia
KW - genetic polymorphism
KW - human diseases
KW - interleukin 1
KW - Hawaii
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Polynesia
KW - Oceania
KW - Pacific Islands
KW - United States of America
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063098758&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T09-4FWK686-1&_user=3891418&_handle=V-WA-A-W-WW-MsSAYVA-UUA-U-AACWBCCWCB-AAVEEBZUCB-EWWEADCZZ-WW-U&_fmt=full&_coverDate=02%2F28%2F2006&_rdoc=5&_orig=browse&_srch=%23toc%234857%232006%23999729997%23614557!&_cdi=4857&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=4cfd7d7efb1c93f5c8f03da1fcf77629
UR - email: byucesoy@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue transgenic rats.
AU - Manjanatha, M.
AU - Shelton, S.
AU - Bishop, M.
AU - Lyn-Cook, L.
AU - Aidoo, A.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 2006///
VL - 27
IS - 10
SP - 1970
EP - 1979
CY - Oxford; UK
PB - Oxford University Press
SN - 0143-3334
AD - Manjanatha, M.: U.S. FDA National Center for Toxicological Research, Genetic Toxicology, Rockville, MD 20857, USA.
N1 - Accession Number: 20063180714. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 486-66-8, 50-28-2, 446-72-0. Subject Subsets: Agroforestry; Dairy Science; Agricultural Biotechnology; Soyabeans; Human Nutrition
N2 - The major constituents of isoflavones daidzein (DZ) and genistein (GE) interact with the and estrogen receptors in several tissues including mammary tissues. In this study, we used ovariectomy (OVX) to model menopause and determined the effects of DZ, GE or 17β-estradiol (E2) exposures on chemically induced mutagenesis and carcinogenesis in the mammary glands of female Big Blue transgenic rats. The rats were fed control diet containing the isoflavones and E2 and treated with a single oral dose of 7,12-dimethylbenz[a]anthracene (DMBA) at PND50. Animals were euthanized at 16 or 20 weeks post-carcinogen treatment to assess mutant frequencies (MFs) and histopathological parameters, respectively. The isoflavones or E2 supplementation alone resulted in the lac I MFs that were not significantly different from the MFs measured in rats fed the control diet alone. DMBA exposure, however, induced significant increases in the lac I MFs in the mammary tissues of both OVX and INT rats and Hprt MFs in spleen lymphocytes (P<0.01). In general, feeding the isoflavones or E2 did not cause any significant changes in DMBA-induced mutagenicity in the mammary tissues. However, feeding the isoflavone mixture (daidzein+genistein; DZG) resulted in a significant reduction in the DMBA-induced lac I MFs (P<0.05). Cell proliferation as measured by PCNA immunohistochemistry was increased in both OVX and INT rats exposed to DMBA as compared with rats fed control diet (P<0.05). Mammary histology indicated that hyperplasia was induced in most of the treatment groups including control. Although DMBA did not induce mammary tumors in the OVX rats, adenoma and adenocarcinoma were detected in the mammary glands of INT rats.
KW - adenocarcinoma
KW - adenoma
KW - anticarcinogenic properties
KW - carcinogenesis
KW - daidzein
KW - disease models
KW - estradiol
KW - genistein
KW - isoflavones
KW - laboratory animals
KW - lymphocytes
KW - mammary gland neoplasms
KW - mammary glands
KW - mammary hyperplasia
KW - menopause
KW - mutagenesis
KW - neoplasms
KW - soyabeans
KW - spleen
KW - Glycine (Fabaceae)
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - anti-carcinogenic properties
KW - biochanin A
KW - cancers
KW - mammary tumour
KW - oestradiol
KW - soybeans
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063180714&site=ehost-live&scope=site
UR - http://carcin.oxfordjournals.org/
UR - email: mmanjanatha@nctr.fda.gov\mugimane@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heterogeneity of vat(E)-carrying plasmids in Enterococcus faecium recovered from human and animal sources.
AU - Simjee, S.
AU - Zhang, Y. F.
AU - McDermott, P. F.
AU - Donabedian, S. M.
AU - Zervos, M. J.
AU - Meng, J. H.
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2006///
VL - 28
IS - 3
SP - 200
EP - 205
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0924-8579
AD - Simjee, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20063185852. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 120138-50-3. Subject Subsets: Veterinary Science; Public Health; Poultry; Veterinary Science
N2 - In this study, quinupristin/dalfopristin (Q/D)-resistant Enterococcus faecium isolates (33 from poultry farms and 1 from a human outpatient) with Q/D minimal inhibitory concentrations ranging from 4 µg/mL to 32 µg/mL were analysed. Polymerase chain reaction detected the presence of vat(E) in all isolates. Using pulsed-field gel electrophoresis (PFGE), 14 distinct PFGE patterns were identified. The human E. faecium isolate was distinguishable from the 33 farm isolates by PFGE. Southern hybridisation localised the vat(E) gene to an 11 kb plasmid and resulted in five plasmid hybridisation types. The vat(E)-carrying plasmid from the human isolate showed a nearly identical hybridisation pattern to a plasmid from a farm isolate. This study showed that the vat(E) gene, conferring resistance to Q/D, was carried on different plasmids in a heterogeneous group of E. faecium, some of which may be acquired by E. faecium capable of infecting humans.
KW - bacterial diseases
KW - drug resistance
KW - genes
KW - human diseases
KW - plasmids
KW - poultry
KW - quinupristin
KW - Indiana
KW - Michigan
KW - USA
KW - Enterococcus faecium
KW - man
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - Lake States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - dalfopristin
KW - domesticated birds
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063185852&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09248579
UR - email: jmeng@umd.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Waste incineration - how big is the health risk? A quantitative method to allow comparison with other health risks.
AU - Roberts, R. J.
AU - Chen MengFang
JO - Journal of Public Health
JF - Journal of Public Health
Y1 - 2006///
VL - 28
IS - 3
SP - 261
EP - 266
CY - Oxford; UK
PB - Oxford University Press
SN - 1741-3842
AD - Roberts, R. J.: National Public Health Service for Wales, Abton House, Wedal Road, Cardiff, CF14 3QX, UK.
N1 - Accession Number: 20063190558. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 7446-09-5. Subject Subsets: Public Health
N2 - Objective: To assess the health risk from a medium-sized waste incinerator and develop a single comparable figure to quantify overall risk. Method: We used a prospective health risk assessment utilizing US Environmental Protection Agency Human Health Risk Assessment Protocol (HHRAP) for Hazardous Waste Combustion Facilities and UK coefficients for the impact of sulphur dioxide and particulates. Calculations were based on a resident population of 25 398 living within 5.5 km of the site. Results: Anxiety, employment, noise, occupational risks, road accidents, and reduced use of landfill were all considered to have a potential, but unquantifiable, effect on health. Stack emissions over 25 years in a population of 25 398 within 5.5 km of the stack would result in an additional 0.018 cancers, 0.46 deaths brought forward due to sulphur dioxide and 0.02 deaths due to fine particles. The overall risk of dying due to emissions in any one year was 2.49×10-7 or 1 in 4 million. Conclusion: To facilitate better public understanding of the comparative risk of incinerator emissions, we propose a simple method of deriving a single annual risk figure allowing comparison with the risk of dying from other causes with which the public is more familiar.
KW - air pollutants
KW - air pollution
KW - anxiety
KW - dioxins
KW - employment
KW - exposure
KW - health hazards
KW - human diseases
KW - landfills
KW - mortality
KW - neoplasms
KW - noise
KW - occupational hazards
KW - refuse
KW - risk assessment
KW - sulfur dioxide
KW - toxic gases
KW - traffic accidents
KW - waste disposal
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - atmospheric pollution
KW - Britain
KW - cancers
KW - death rate
KW - incineration
KW - jobs
KW - municipal wastes
KW - noxious gases
KW - particulate matter
KW - sulphur dioxide
KW - trash
KW - United Kingdom
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Human Wastes and Refuse (XX300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063190558&site=ehost-live&scope=site
UR - http://jpubhealth.oxfordjournals.org/
UR - email: richard.roberts@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Informed choice in screening programmes: do leaflets help? A critical literature review.
AU - Fox, R.
JO - Journal of Public Health
JF - Journal of Public Health
Y1 - 2006///
VL - 28
IS - 4
SP - 309
EP - 317
CY - Oxford; UK
PB - Oxford University Press
SN - 1741-3842
AD - Fox, R.: National Public Health Service for Wales, Temple of Peace and Health Cathays Park, Cardiff CF10 3NW, UK.
N1 - Accession Number: 20073001188. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Background: Screening programmes aim to maximise population benefit by maximizing uptake but must also allow informed choice about participation. Many programmes provide potential participants with information leaflets. This article reviews studies of the effectiveness of leaflets in promoting informed choice in screening. Methods: I searched 15 electronic databases and the websites of UK screening programmes, searched the bibliographies of identified studies and contacted experts in the field. Randomized controlled trials (RCTs) and controlled clinical trials where an attempt had been made to determine the contribution of leaflets to the exercise of informed choice in screening decisions were included. Results: I identified nine trials from various screening programmes. Outcome measures included knowledge, attitudes to screening, intention to be screened, uptake, anxiety, satisfaction with decision-making, discussions about screening with care providers and agreement that enough information had been provided to allow informed choice. Most studies demonstrated that providing written information increased knowledge, but evidence that this promoted informed choice was poor. Conclusions: Research into informed choice in screening is hampered by the lack of agreement about its definition and measurement. The most effective way for screening programmes to achieve informed choice is unclear. Programmes should not rely solely on providing written information but should explore additional ways to promote informed choice.
KW - consent
KW - decision making
KW - publications
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - choice
KW - screening tests
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073001188&site=ehost-live&scope=site
UR - http://jpubhealth.oxfordjournals.org/
UR - email: rosemary.fox@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Healthcare workers with tuberculosis infected during work.
AU - Vries, G. de
AU - Sebek, M. M. G. G.
AU - Lambregts-van Weezenbeek, C. S. B.
JO - European Respiratory Journal
JF - European Respiratory Journal
Y1 - 2006///
VL - 28
IS - 6
SP - 1216
EP - 1221
CY - Sheffield; UK
PB - European Respiratory Society
SN - 0903-1936
AD - Vries, G. de: Dept of Tuberculosis Control, Municipal Public Health Service, P.O. Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20063229963. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - The risk for health care workers (HCWs) of tuberculosis (TB) attributable to occupational exposure is difficult to determine, as are the conditions contributing to this risk. The objective of the present study was to determine which TB cases among HCWs in the Netherlands were infected during work and to analyse factors which contributed to infection and subsequent disease. The total study population consisted of 101 cases over a 5-year period. In 67 (66%) subjects the route of infection could be determined by epidemiological and microbiological information. Of these cases, 28 out of 67 (42%) were due to infection at work, 19 (28%) were community-acquired, and 20 (30%) were infected abroad. The 28 cases infected at work were subject to an in-depth analysis. Delayed diagnosis of the index case, especially in the elderly patient, was the main cause of patient-to-HCW transmission. In some circumstances, inadequate infection-control measures also contributed to transmission. In conclusion, a high suspicion of tuberculosis by the clinician, adequate infection control measures by hospital authorities, and early identification of latent tuberculosis infection by occupational and public-health specialists are necessary to prevent tuberculosis among health care workers.
KW - elderly
KW - health care workers
KW - human diseases
KW - latent infections
KW - occupational health
KW - tuberculosis
KW - Netherlands
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - aged
KW - bacterium
KW - elderly people
KW - older adults
KW - senior citizens
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063229963&site=ehost-live&scope=site
UR - http://www.erj.ersjournals.com
UR - email: devriesg@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interactions between schistosomiasis and infection with HIV-1.
AU - Secor, W. E.
A2 - Hunter, C. A.
A2 - Whitworth, J. A. G.
T3 - Special Issue: Immune deficiencies and parasitic diseases.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2006///
VL - 28
IS - 11
SP - 597
EP - 603
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0141-9838
AD - Secor, W. E.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20063210937. Publication Type: Journal Article. Note: Special Issue: Immune deficiencies and parasitic diseases. Language: English. Number of References: 59 ref. Subject Subsets: Tropical Diseases; Helminthology; Public Health
N2 - In many regions of the world, both schistosomiasis and HIV/AIDS are endemic, resulting in patients harbouring co-infections. Because interaction with host CD4+ T cells is a characteristic of schistosome as well as HIV-1 infections, bi-directional disease effects may be sufficiently different from sequelae caused by either infectious agent alone to warrant alteration of public health approaches in areas of co-endemnicity. Studies published over the past decade provide useful insights into interactions between schistosomiasis and infection with HIV-1, and overall support the hypothesis that special emphasis on treatment of schistosomiasis in populations with elevated prevalence or risk of HIV-1 infection is justified.
KW - acquired immune deficiency syndrome
KW - CD4+ lymphocytes
KW - concurrent infections
KW - HIV-1 infections
KW - human diseases
KW - immunology
KW - reviews
KW - schistosomiasis
KW - trematode infections
KW - viral diseases
KW - Human immunodeficiency virus 1
KW - man
KW - Schistosoma
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - AIDS
KW - bilharzia
KW - bilharziasis
KW - CD4+ cells
KW - fluke infections
KW - Human immunodeficiency virus type 1
KW - schistosomosis
KW - Strigeida
KW - T4 lymphocytes
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063210937&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=pim
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Immunization to protect the US Armed Forces: heritage, current practice, and prospects.
AU - Grabenstein, J. D.
AU - Pittman, P. R.
AU - Greenwood, J. T.
AU - Engler, R. J. M.
JO - Epidemiologic Reviews
JF - Epidemiologic Reviews
Y1 - 2006///
VL - 28
SP - 3
EP - 26
CY - Cary; USA
PB - Oxford University Press
SN - 0193-936X
AD - Grabenstein, J. D.: Military Vaccine Agency, Office of the Surgeon General, 5113 Leesburg Pike, US Army, Falls Church, VA 22041, USA.
N1 - Accession Number: 20063161798. Publication Type: Journal Article. Language: English. Number of References: 324 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Public Health
N2 - Americans serving with the US Armed Forces need protection from the dangerous infections that they can contract during training, based on occupation, during overseas deployment, or because of underlying health status. For over 230 years, the military health-care system has immunized troops to protect them personally and to help them accomplish their missions. Military researchers have invented, developed, and improved vaccines and immunization delivery methods against more than 20 diseases. This article consolidates content from several previous historical reviews, adds additional sources, and cites primary literature regarding military contributions and accomplishments. Discussion emphasizes smallpox, typhoid fever, tetanus, influenza, meningococcal disease, adenovirus, yellow fever, pneumococcal disease, and anthrax. Delivery issues include documentation, simultaneous immunization, seroscreening, safety surveillance, jet injection, and cold-chain management. Immunization policies for each major US conflict are described. Military immunization programs need to be individualized on the basis of personal contraindications and prior immunity. The proper conduct of military immunization programs respects the need for detailed education of military personnel, maximizes quality in immunization delivery, and supports quality clinical care to prevent and treat adverse events after immunization. Military immunization programs maintain the health of soldiers, marines, sailors, airmen, and coast guardsmen, the resources most critical to military success.
KW - anthrax
KW - bacterial diseases
KW - bacterial meningitis
KW - history
KW - immunization
KW - immunization programmes
KW - influenza
KW - influenza viruses
KW - military personnel
KW - occupational hazards
KW - occupational health
KW - reviews
KW - smallpox
KW - tetanus
KW - typhoid
KW - vaccination
KW - viral diseases
KW - yellow fever
KW - USA
KW - Adenoviridae
KW - Bacillus anthracis
KW - Clostridium tetani
KW - Neisseria meningitidis
KW - Salmonella typhi
KW - Streptococcus pneumoniae
KW - Variola virus
KW - Yellow fever virus
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - flu
KW - immune sensitization
KW - immunization programs
KW - Influenzavirus
KW - lockjaw
KW - Meningococcus
KW - United States of America
KW - viral infections
KW - History and Biography (BB500)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063161798&site=ehost-live&scope=site
UR - http://epirev.oxfordjournals.org/cgi/content/full/28/1/3
UR - email: john.grabenstein@us.army.mil
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors affecting the ultraviolet inactivation of Escherichia coli K12 in apple juice and a model system.
AU - Murakami, E. G.
AU - Jackson, L.
AU - Madsen, K.
AU - Schickedanz, B.
JO - Journal of Food Process Engineering
JF - Journal of Food Process Engineering
Y1 - 2006///
VL - 29
IS - 1
SP - 53
EP - 71
CY - Boston; USA
PB - Blackwell Publishing
SN - 0145-8876
AD - Murakami, E. G.: Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Ave., Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063042178. Publication Type: Journal Article. Language: English. Number of References: 24 ref.
N2 - Ultraviolet (UV) light has been used successfully for years to sterilize water and was recently approved as an acceptable irradiation treatment for the processing of juice. Although there is considerable information on the efficacy of UV processing in the treatment of water, limited data are available on its efficacy in fluid food systems. The objectives of this study were to determine the effects of apple juice properties on the UV inactivation of Escherichia coli K12, and the interdependence of intensity and time on the efficacy of UV light. The results showed that absorbance (α=0.6-2.2/mm) and suspended solids (0-5 g/ml) affected UV inactivation of E. coli K12, while pH (3-5) and dissolved solids (10-20 Brix) did not. Concerning the interdependence of intensity and time, intensity levels could only be changed without sacrificing effectiveness at a limited range of intensity and dose levels. This means that the range of the intensity level of the actual UV reactor must be considered in process-parameter determination.
KW - absorbance
KW - apple juice
KW - food contamination
KW - food irradiation
KW - microbial contamination
KW - pH
KW - suspended solids
KW - time
KW - ultraviolet radiation
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - food contaminants
KW - hydrogen ion concentration
KW - optical density
KW - potential of hydrogen
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063042178&site=ehost-live&scope=site
UR - email: Edgar.Murakami@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acceptability of self-taken vaginal swabs and first-catch urine samples for the diagnosis of urogenital Chlamydia trachomatis and Neisseria gonorrhoeae with an amplified DNA assay in young women attending a public health sexually transmitted disease clinic.
AU - Hoebe, C. J. P. A.
AU - Rademaker, C. W.
AU - Brouwers, E. E. H. G.
AU - Waarbeek, H. L. G. ter
AU - Bergen, J. E. A. M. van
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2006///
VL - 33
IS - 8
SP - 491
EP - 495
CY - Philadelphia; USA
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Hoebe, C. J. P. A.: Department of Infectious Diseases, South Limburg Public Health Service, PO Box 155, NL-6400 AD Heerlen, Netherlands.
N1 - Accession Number: 20083196824. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - Objectives: Public health efforts are needed to encourage young women to get tested for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). Goal: To assess the acceptability and feasibility of 2 noninvasive diagnostic approaches. Study Design: Participants of this cross-sectional survey were 413 young women (age 16-35) who underwent STD testing by self-taken vaginal swab (SVS) and a first-catch urine sample (FCU) by nucleic acid amplification test (BDProbTec) and filled out a questionnaire. Results: CT and GC were diagnosed in 10.9% (45/413) and 1.5% (6/413). Eleven percent of the participants who never previously had an STD examination (68%) tested STD positive. SVS and FCU were almost uniformly reported as easy to perform and preferred above gynecologic examination. Conclusions: Using SVS combined with FCU can be an important enhancing tool in public health approaches. Acceptability among potential patients is high, enabling the noninvasive detection of STDs that would otherwise remain undetected and untreated.
KW - acceptability
KW - bacterial diseases
KW - diagnosis
KW - diagnostic techniques
KW - gonorrhoea
KW - human diseases
KW - molecular genetics techniques
KW - public health
KW - sexually transmitted diseases
KW - urine analysis
KW - vaginal smears
KW - women
KW - Netherlands
KW - Chlamydia trachomatis
KW - man
KW - Neisseria gonorrhoeae
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - gonorrhea
KW - STDs
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083196824&site=ehost-live&scope=site
UR - http://www.stdjournal.com/pt/re/std/fulltext.00007435-200608000-00006.htm;jsessionid=LN3XGfb1LQ1Dt7Jvv9q8hdGhWMrjjx17KzgZgMLy6nsXQdpWHXny!1629792715!181195629!8091!-1
UR - email: hoebec@ggdozl.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of benzethonium chloride in anthrax vaccine adsorbed by HPLC.
AU - Wang, H. L.
AU - Grosso, A. V. del
AU - May, J. C.
JO - Biologicals
JF - Biologicals
Y1 - 2006///
VL - 34
IS - 4
SP - 257
EP - 263
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1045-1056
AD - Wang, H. L.: Laboratory of Analytical Chemistry, Office of Vaccine Research and Review, Center of Biological Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM-406, Rockville, MD 20852, USA.
N1 - Accession Number: 20063231218. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - A novel and sensitive HPLC method for the determination of benzethonium chloride (BZC) in anthrax vaccine was developed. Adjuvant Alhydrogel was removed by syringe filter after a simple sample pretreatment - acidification prior to injection. Chromatography was performed by isocratic reverse phase separation with methanol/262 mM ammonium acetate (80/20, v/v) on an endcapped C18 column with diode array detector (DAD). The method showed excellent recovery (100±1.5%). The results indicated that this method could accurately determine BZC at the limit of detection (LOD) of 0.5 ppm and the limit of quantitation (LOQ) of 1.5 ppm with dynamic range up to 100 ppm. The comparison of analysis between new HPLC and old titrimetric methods is also reported. The HPLC method is proven to be more accurate and precise with much less vaccine sample and human labor required.
KW - analytical methods
KW - anthrax
KW - determination
KW - HPLC
KW - vaccines
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - benzethonium chloride
KW - high performance liquid chromatography
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063231218&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10451056
UR - email: wangh@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative molecular characterization of gene segment 11-derived NSP6 from lamb rotavirus LLR strain used as a human vaccine in China.
AU - Mohan, K. V. K.
AU - Glass, R. I.
AU - Atreya, C. D.
JO - Biologicals
JF - Biologicals
Y1 - 2006///
VL - 34
IS - 4
SP - 265
EP - 272
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1045-1056
AD - Mohan, K. V. K.: Section of Viral Pathogenesis and Vaccine Adverse Reactions, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063231219. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases
N2 - Sequence-length polymorphism is known for rotavirus genetic segment 11 (encodes non-structural protein, NSP6). With the exception of 11 strains that have the coding potential for a 98-residue NSP6, majority of the strains have the potential for a 92-residue NSP6. In nine strains, the coding potential for this protein is even shorter. This report focuses on the NSP6 gene nucleotide sequence of Lanzhou Lamb Rotavirus (LLR) strain and its comparative molecular characterization. The LLR strain is a G10 P12 type, which is in use as a licensed human vaccine in China. The LLR NSP6 was compared with 56 other rotaviral NSP6 sequences including a rhesus strain (RRV) available in the database. Analyses indicate that while RRV-NSP6 belongs to the majority (92-residue) group, the LLR NSP6 belongs to the 98-residue group. When the rotavirus NSP6 protein was expressed in cells as GFP fusion protein from human, simian and the LLR strains, they all demonstrated punctate cytoplasmic distribution and, contrary to the computer-aided prediction, the NSP6 did not undergo phosphorylation, which in itself is a novel observation for the rotavirus NSP6.
KW - cytoplasm
KW - genes
KW - nucleotide sequences
KW - phosphorylation
KW - strains
KW - vaccine development
KW - vaccines
KW - China
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - DNA sequences
KW - People's Republic of China
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063231219&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10451056
UR - email: atreya@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epidemic spread of recombinant noroviruses with four capsid types in Hungary.
AU - Reuter, G.
AU - Vennema, H.
AU - Koopmans, M.
AU - Szücs, G.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006///
VL - 35
IS - 1
SP - 84
EP - 88
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság ut 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20063069367. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n=9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n=6, 28%), Hu/NLV/GGII/Hawaii/1971 (n=4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n=1, 5%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants - next to GGII-4/Lordsdale virus - causing epidemics of gastroenteritis in the last 4 years.
KW - epidemics
KW - epidemiology
KW - gastroenteritis
KW - human diseases
KW - outbreaks
KW - viral diseases
KW - Hungary
KW - Caliciviridae
KW - man
KW - Norovirus
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - viral infections
KW - winter vomiting disease
KW - winter vomiting virus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063069367&site=ehost-live&scope=site
UR - email: reuterg@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends and disparities in socioeconomic and behavioural characteristics, life expectancy, and cause-specific mortality of native-born and foreign-born populations in the United States, 1979-2003.
AU - Singh, G. K.
AU - Hiatt, R. A.
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Y1 - 2006///
VL - 35
IS - 4
SP - 903
EP - 919
CY - Oxford; UK
PB - Oxford University Press
SN - 0300-5771
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20063205584. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - Background: Immigrants are a growing segment of the US population. In 2003, there were 33.5 million immigrants, accounting for 12% of the total US population. Despite a rapid increase in their numbers, little information exists as to how immigrants' health and mortality profile has changed over time. In this study, we analysed trends in social and behavioural characteristics, life expectancy, and mortality patterns of immigrants and the US-born from 1979 to 2003. Methods: We used national mortality and census data (1979-2003) and 1993 and 2003 National Health Interview Surveys to examine nativity differentials over time in health and social characteristics. Life tables, age-adjusted death rates, and logistic regression were used to examine nativity differentials. Results: During 1979-81, immigrants had 2.3 years longer life expectancy than the US-born (76.2 vs 73.9 years). The difference increased to 3.4 years in 1999-2001 (80.0 vs 76.6 years). Nativity differentials in mortality increased over time for major cancers, cardiovascular diseases, diabetes, respiratory diseases, unintentional injuries, and suicide, with immigrants experiencing generally lower mortality than the US-born in each period. Specifically, in 1999-2001, immigrants had at least 30% lower mortality from lung and oesophageal cancer, COPD, suicide, and HIV/AIDS, but at least 50% higher mortality from stomach and liver cancer than the US-born. Nativity differentials in mortality, health, and behavioural characteristics varied substantially by ethnicity. Conclusions: Growing ethnic heterogeneity of the immigrant population, and its migration selectivity and continuing advantages in behavioural characteristics may partly explain the overall widening health gaps between immigrants and the US-born.
KW - acquired immune deficiency syndrome
KW - behaviour
KW - cardiovascular diseases
KW - chronic obstructive pulmonary disease
KW - diabetes mellitus
KW - disparity
KW - ethnic groups
KW - ethnicity
KW - HIV infections
KW - human behaviour
KW - human diseases
KW - Human immunodeficiency viruses
KW - immigrants
KW - life expectancy
KW - liver
KW - liver cancer
KW - lung cancer
KW - lungs
KW - mortality
KW - neoplasms
KW - oesophageal cancer
KW - oesophagus
KW - respiratory diseases
KW - socioeconomics
KW - stomach
KW - stomach cancer
KW - suicide
KW - trauma
KW - trends
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - behavior
KW - cancers
KW - death rate
KW - esophageal cancer
KW - esophagus
KW - ethnic differences
KW - human behavior
KW - human immunodeficiency virus infections
KW - lung diseases
KW - socioeconomic aspects
KW - traumas
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063205584&site=ehost-live&scope=site
UR - http://ije.oxfordjournals.org/
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Widening socioeconomic inequalities in US life expectancy, 1980-2000.
AU - Singh, G. K.
AU - Mohammad Siahpush
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Y1 - 2006///
VL - 35
IS - 4
SP - 969
EP - 979
CY - Oxford; UK
PB - Oxford University Press
SN - 0300-5771
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20063205590. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Background: This study examines changes in the extent of inequalities in life expectancy at birth and other ages in the United States between 1980 and 2000 by gender and socioeconomic deprivation levels. Methods: A factor-based deprivation index consisting of 11 education, occupation, wealth, income distribution, unemployment, poverty, and housing quality indicators was used to define deprivation deciles, which were then linked to the US mortality data at the county-level. Life expectancy estimates were developed by age, gender, and deprivation levels for three 3 year time periods: 1980-82, 1989-91, and 1998-2000. Inequalities in life expectancy were measured by the absolute difference between the least-deprived group and each of the other deprivation deciles. Slope indices of inequality for each gender and time period were calculated by regressing life expectancy estimates on deprivation levels using weighted least squares models. Results: Those in less-deprived groups experienced a longer life expectancy at each age than their counterparts in more-deprived groups. In 1980-82, the overall life expectancy at birth was 2.8 years longer for the least-deprived group than for the most-deprived group (75.8 vs 73.0 years). By 1998-2000, the absolute difference in life expectancy at birth had increased to 4.5 years (79.2 vs 74.7 years). The inequality indices also showed a substantial widening of the deprivation gradient in life expectancy during the study period for both males and females. Conclusions: Between 1980 and 2000, those in higher socioeconomic groups experienced larger gains in life expectancy than those in more-deprived groups, contributing to the widening gap.
KW - deprivation
KW - disparity
KW - life expectancy
KW - social inequalities
KW - socioeconomic status
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063205590&site=ehost-live&scope=site
UR - http://ije.oxfordjournals.org/
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A primer on economic evaluations related to expansion of newborn screening for genetic and metabolic disorders.
AU - Hubbard, H. B.
JO - Journal of Obstetric, Gynecologic, & Neonatal Nursing
JF - Journal of Obstetric, Gynecologic, & Neonatal Nursing
Y1 - 2006///
VL - 35
IS - 6
SP - 692
EP - 699
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0884-2175
AD - Hubbard, H. B.: Agency for Healthcare Research and Quality, 540 Gaither Road, Room 3337, Rockville, MD 20850, USA.
N1 - Accession Number: 20073134643. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - Newborns in every state are screened for genetic/metabolic disorders, but there is no uniform national screening program. Recently, a federal panel concluded that the number of disorders screened should be increased from 9 to 29. In order for state leaders, and for the clinicians who inform them, to make sound decisions about expanding newborn screening programs, they need to be aware of the costs and outcomes of the entire screening program. This paper examines newborn screening from several perspectives: status of state programs, screening technology, and financing. In addition, various types of economic evaluations are defined, and a number of economic studies are explored.
KW - cost analysis
KW - costs
KW - economic evaluation
KW - genetic disorders
KW - human diseases
KW - metabolic disorders
KW - neonates
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - costing
KW - costings
KW - genetic defects
KW - hereditary defects
KW - metabolic diseases
KW - newborn infants
KW - screening tests
KW - Health Economics (EE118) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073134643&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jogn
UR - email: heddy.hubbard@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of a novel variant of human hepatitis E virus in Hungary.
AU - Reuter, G.
AU - Fodor, D.
AU - Kátai, A.
AU - Szucs, G.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006///
VL - 36
IS - 2
SP - 100
EP - 102
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság út. 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20063118272. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health; Pig Science
N2 - The first human case of hepatitis E infection detected in Hungary is reported. This hepatitis E virus (HEV), Hungary1, belongs to genotype 3 and had 95% and 90% nucleotide identity within the capsid region of the European swine and human (Greece2) strains, respectively. Hungary1 represents a potential novel human variant of HEV in genus Hepevirus.
KW - case reports
KW - clinical aspects
KW - geographical distribution
KW - hepatitis E
KW - human diseases
KW - liver
KW - liver diseases
KW - new geographic records
KW - viral hepatitis
KW - Hungary
KW - Hepatitis E virus
KW - man
KW - Hepatitis E-like viruses
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - clinical picture
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063118272&site=ehost-live&scope=site
UR - email: reuterg@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Competition enzyme-linked immunosorbant assay (ELISA) can be a sensitive method for the specific detection of small quantities of allergen in a complex mixture.
AU - Dobrovolskaia, E.
AU - Gam, A.
AU - Slater, J. E.
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
Y1 - 2006///
VL - 36
IS - 4
SP - 525
EP - 530
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0954-7894
AD - Dobrovolskaia, E.: Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20852, USA.
N1 - Accession Number: 20073008271. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Rationale: The competition ELISA assay is used to determine the potency of US standardized allergen extracts. We have been concerned that the competition ELISA is not sensitive to changes in individual allergen levels. This study was designed to determine the sensitivity of the competition ELISA to detect the specific loss of Bla g 1 and Bla g 2 in cockroach extracts. Methods: German cockroach extract E3C g was made from defatted German cockroaches. New Zealand White rabbits were immunized with rBla g 1 or rBla g 2. Optimal dilutions of anti-Bla g 1 and anti-Bla g 2 sera were established by ELISA. E3C g was selectively depleted of Bla g 1 or Bla g 2 by immunoabsorption with anti-Bla g 1 or anti-Bla g 2 attached to Protein G agarose beads. Competition ELISA using pooled human sera, or mixed anti-Bla g 1 and anti-Bla g 2 serum, was performed on the depleted extracts, and on depleted extracts reconstituted with rBla g 1 or rBla g 2. Results: Unlike pooled human-allergic IgE sera, anti-Bla g 1 and anti-Bla g 2 IgG - in dilutions as low as 10-6, could be used in the competition ELISA to measure the loss of allergen in depleted E3C g. As little as 0.001 µg/mL of added rBla g 1 and 0.1 µg/mL of added rBla g 2, could be detected. Conclusion: The competition ELISA can be highly sensitive to compositional differences in complex allergen mixtures, even when the specific detecting antibody is present in relatively small amounts.
KW - allergens
KW - detection
KW - ELISA
KW - mixtures
KW - Blattella germanica
KW - Blattella
KW - Blattellidae
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Blattodea
KW - enzyme linked immunosorbent assay
KW - German cockroach
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073008271&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=cea
UR - email: slaterj@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protein disulfide isomerase assisted protein folding in malaria parasites.
AU - Mahajan, B.
AU - Noiva, R.
AU - Yadava, A.
AU - Zheng, H.
AU - Majam, V.
AU - Mohan, K. V. K.
AU - Moch, J. K.
AU - Haynes, J. D.
AU - Nakhasi, H.
AU - Kumar, S.
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 2006///
VL - 36
IS - 9
SP - 1037
EP - 1048
CY - Oxford; UK
PB - Elsevier
SN - 0020-7519
AD - Mahajan, B.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20895, USA.
N1 - Accession Number: 20063162377. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 52-90-4. Subject Subsets: Protozoology; Public Health
N2 - In eukaryotes, the formation of protein disulfide bonds among cysteine residues is mediated by protein disulfide isomerases and occurs in the highly oxidised environment of the endoplasmic reticulum. This process is poorly understood in malaria parasites. In this paper, we report the gene isolation, sequence and phylogenetic comparisons, protein structure and thioredoxin-domain analyses of nine protein disulfide isomerases-like molecules from five species of malaria parasites including Plasmodium falciparum and Plasmodium vivax (human), Plasmodium knowlesi (simian) and Plasmodium berghei and Plasmodium yoelii (murine). Four of the studied protein disulfide isomerases belong to P. falciparum malaria and have been named PfPDI-8, PfPDI-9, PfPDI-11 and PfPDI-14, based on their chromosomal location. Among these, PfPDI-8 bears the closest similarity to a prototype PDI molecule with two thioredoxin domains (containing CGHC active sites) and a C-terminal Endoplasmic reticulum retrieval signal, SEEL. PfPDI-8 is expressed during all stages of parasite life cycle and is highly conserved (82-96% identity at amino acid level) in the other four Plasmodium species studied. Detailed biochemical analysis of PfPDI-8 revealed that this molecule is a potent oxido-reductase enzyme that facilitated the disulfide-dependent conformational folding of EBA-175, a leading malaria vaccine candidate. These studies open the avenues to understand the process of protein folding and secretory pathway in malaria parasites that in turn might aid in the production of superior recombinant vaccines and provide novel drug targets.
KW - cysteine
KW - human diseases
KW - malaria
KW - molecular biology
KW - molecular genetics
KW - Plasmodium berghei
KW - Plasmodium falciparum
KW - Plasmodium knowlesi
KW - Plasmodium vivax
KW - Plasmodium yoelii
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - protein disulfide isomerase
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063162377&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00207519
UR - email: sanjai.kumar@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence and molecular characterization of human group C rotaviruses in Hungary.
AU - Bányai, K.
AU - Jiang, B.
AU - Bogdán, Á.
AU - Horváth, B.
AU - Jakab, F.
AU - Meleg, E.
AU - Martella, V.
AU - Magyari, L.
AU - Melegh, B.
AU - Szucs, G.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006///
VL - 37
IS - 4
SP - 317
EP - 322
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7., H-7623 Pécs, Hungary.
N1 - Accession Number: 20063239128. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Background: Group C rotaviruses are recognized enteric pathogens of humans and animals. Human group C rotaviruses have been associated with sporadic episodes and large outbreaks of gastroenteritis in children and adults but their epidemiology and ecology are still unexplored. Objectives: To collect epidemiological data on group C rotavirus infections among children with gastroenteritis in Hungary and perform molecular characterization on the identified strains. Study design: Fecal samples were collected during the 2003 surveillance in Baranya County, Hungary. The presence of group C rotavirus RNA was investigated by polyacrylamide gel electrophoresis and by reverse transcription-nested polymerase chain reaction for the VP6 gene. The identified strains were further characterized by sequencing and phylogenetic analysis of the VP7, VP6, VP4, and NSP4 genes. Results: Three of 472 samples (0.6%) tested positive for group C rotavirus. Two samples were selected for molecular analysis. Strains BaC 6104/03 and BaC 11549/03 displayed an overall identity of >99.8% and 99.3% at the nucleotide and amino acid level, respectively. The VP7 of the strain BaC 6104/03 was most closely related (99.5% aa) to the Nigerian strain Jajeri, while the VP4s of strains BaC 6104/03 and BaC 11549/03 were more similar (98.1% aa) to strains Belem and 208, detected in Brazil and China, respectively. Conclusions: Based on this 1-year study, we conclude that group C rotaviruses are not of epidemiological relevance in the etiology of childhood acute gastroenteritis in Hungary. The low sequence divergence between the Hungarian strains suggested that a single group C rotavirus strain circulated in this period in the study area.
KW - children
KW - disease prevalence
KW - gastroenteritis
KW - genotypes
KW - human diseases
KW - molecular epidemiology
KW - nucleotide sequences
KW - outbreaks
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - DNA sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063239128&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/13866532
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High caffeine intake in adolescents: associations with difficulty sleeping and feeling tired in the morning.
AU - Orbeta, R. L.
AU - Overpeck, M. D.
AU - Ramcharran, D.
AU - Kogan, M. D.
AU - Ledsky, R.
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
Y1 - 2006///
VL - 38
IS - 4
SP - 451
EP - 453
CY - New York; USA
PB - Elsevier
SN - 1054-139X
AD - Orbeta, R. L.: Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Office of Data and Information Management, 5600 Fisheries Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20063114166. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 58-08-2. Subject Subsets: Public Health
N2 - The objective of this study was to examine the association between caffeine usage in U.S. adolescents and the frequency that feeling tired in the morning and having difficulty sleeping is reported. In this study we found that feeling tired in the morning and having difficulty sleeping was experienced more commonly in those adolescents that have a high intake of caffeine.
KW - adolescents
KW - caffeine
KW - children
KW - intake
KW - sleep
KW - soft drinks
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - sleep disorders
KW - teenagers
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063114166&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T80-4JH47CN-V-1&_cdi=5072&_user=3891418&_orig=browse&_coverDate=04%2F30%2F2006&_sk=999619995&view=c&wchp=dGLbVlz-zSkzS&md5=d980d81124edf48d47bb1dfecdea9c6d&ie=/sdarticle.pdf
UR - email: btingle76@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumption of dietary supplements containing Citrus aurantium (bitter orange) - 2004 California Behavioral Risk Factor Surveillance Survey (BRFSS).
AU - Klontz, K. C.
AU - Timbo, B. B.
AU - Street, D.
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
Y1 - 2006///
VL - 40
IS - 10
SP - 1747
EP - 1751
CY - Cincinnati; USA
PB - Harvey Whitney Books Company
SN - 1060-0280
AD - Klontz, K. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063209006. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - BACKGROUND: Following the marketing ban of ephedra-containing supplements in April 2004, many manufacturers substituted the herb Citrus aurantium for ephedra and marketed the products as "ephedra-free" supplements. Extracts of C. aurantium contain synephrine, a sympathomimetic alkaloid. OBJECTIVE: To determine the prevalence of consumption of dietary supplements containing C. aurantium in California, USA during 2004. METHODS: We used the 2004 California Behavioral Risk Factor Surveillance Survey to determine the prevalence of consumption of dietary supplements containing C. aurantium in California during 2004. RESULTS: Two percent (n=70) of the 4140 survey respondents reported taking a dietary supplement containing C. aurantium in the previous year. Reasons stated included energy enhancement, weight loss, and appetite suppression. Compared with nonusers, users were more likely to report being single, aged 18-34 years, and Hispanic; consuming 3 or more alcoholic drinks on days that they imbibed; and having a heavier body mass index. Among the 5 users who reported experiencing an adverse event that they attributed to the supplement, 3 indicated that the severity was mild. CONCLUSIONS: Given that supplements containing ephedra were banned in April 2004, the results from this study may serve as a baseline estimate against which future studies of the use of C. aurantium products may be compared.
KW - anorexiants
KW - appetite
KW - behaviour
KW - body mass index
KW - epidemiology
KW - food supplements
KW - sour oranges
KW - weight losses
KW - weight reduction
KW - wild relatives
KW - California
KW - Citrus
KW - Citrus aurantium
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Citrus
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anorectics
KW - appetite depressants
KW - appetite suppressors
KW - behavior
KW - Rutales
KW - Seville oranges
KW - Other Produce (QQ070)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063209006&site=ehost-live&scope=site
UR - http://www.theannals.com/cgi/content/abstract/40/10/1747
UR - email: karl.klontz@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - What are qualified health claims?
AU - Ellwood, K. C.
JO - Nutrition Today
JF - Nutrition Today
Y1 - 2006///
VL - 41
IS - 2
SP - 56
EP - 61
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0029-666X
AD - Ellwood, K. C.: Division of Nutrition Programs and Labeling, Office of Nutritional Products, Labeling and Dietary Supplements, US Food and Drug Administration's Center for Food Safety and Applied Nutrition, HFS-830 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073188878. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - Health claims were first authorized through the Nutrition Labeling and Education Act of 1990. The standard that the Congress set for scientific evidence for the claim was the significant scientific agreement standard. This standard was challenged by several manufacturers of dietary supplements. Several court decisions directed the US Food and Drug Administration to provide for qualified health claims on dietary supplements. In December 2002, a major new initiative, "The Consumer Health Information for Better Nutrition Initiative," was announced by the Food and Drug Administration. This initiative provided for the use of qualified health claims for both conventional human foods and dietary supplements. The process for reviewing the scientific evidence for a claim reaching significant scientific agreement and for those that require qualifying language is the same. The Food and Drug Administration must determine the claim language and disclaimer for each claim. Several letters of enforcement discretion for qualified health claims have been issued by the Food and Drug Administration.
KW - consumer protection
KW - consumers
KW - food safety
KW - foods
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073188878&site=ehost-live&scope=site
UR - http://www.nutritiontodayonline.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of ginkgolides and bilobalide in food products using LC-APCI-MS.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
A2 - Chankvetadze, B.
A2 - Cifuentes, A.
T3 - Special Issue: Nutraceuticals Analysis.
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
Y1 - 2006///
VL - 41
IS - 5
SP - 1552
EP - 1559
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0731-7085
AD - Jager, L. S. de: U.S. Food and Drug Administration, Centre for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland, USA.
N1 - Accession Number: 20063166990. Publication Type: Journal Article. Note: Special Issue: Nutraceuticals Analysis. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants
N2 - A method was developed for the extraction and quantification of five marker compounds characteristic of Ginkgo biloba. Five ginkgo terpene trilactones: bilobalide and ginkgolides A, B, C, and J, were selected as marker compounds for this study. Initial studies produced a simple methanol extraction method for determination of gingko markers in solid dietary supplements. Five dietary supplements were analyzed and the results were later compared to the concentrations detected in the analysis of beverages. Beverage samples were prepared by extracting the ginkgo terpene trilactones using an optimized solid phase extraction (SPE) method. The extracts were analyzed using LC-atmospheric pressure chemical ionization (APCI)-MS in the negative ionization mode. The limits of detection of the extraction method ranged from 6.8 to 3.2 ng mL-1. Using the optimized method, 14 drinks and 3 tea products were analyzed. Concentrations of total marker compounds in drinks ranged between 1685 and 21.4 ng mL-1 with individual ginkgo terpene trilactones being detected at ppb concentrations. Analysis of brewed tea products presented much higher total marker compound concentrations ranging from 8.12 and 16.6 µg mL-1. Analytical results reproducibility data, and recovery of the SPE method are presented.
KW - analytical methods
KW - beverages
KW - determination
KW - extraction
KW - extracts
KW - food analysis
KW - food products
KW - liquid chromatography
KW - markers
KW - mass spectrometry
KW - methodology
KW - tea
KW - terpenoids
KW - Camellia sinensis
KW - Ginkgo biloba
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Ginkgo
KW - Ginkgoaceae
KW - Ginkgoopsida
KW - gymnosperms
KW - analytical techniques
KW - bilobalide
KW - drinks
KW - ginkgo tree
KW - ginkgolides
KW - maidenhair tree
KW - methods
KW - terpenes
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063166990&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07317085
UR - email: ldejager@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Desensitization of dust mite drops on antigen-specific asthmatic reaction in guinea pigs.
AU - Li Yun
AU - Xie QiangMin
AU - Chen JiQiang
JO - Acta Pharmaceutica Sinica
JF - Acta Pharmaceutica Sinica
Y1 - 2006///
VL - 41
IS - 7
SP - 641
EP - 646
CY - Beijing; China
PB - Acta Pharmaceutica Sinica
SN - 0513-4870
AD - Li Yun: Respiratory Drugs Laboratory of State Food and Drug Administration of China, College of Medicine, Zhejiang University, Hangzhou 310031, China.
N1 - Accession Number: 20063221024. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 19 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Aim: To establish an antigen-specific asthmatic model of guineapig induced by protein antigen extracted from Dermatophagoides farinae (Der f), and study the desensitization of dust mite drops (DMD, extracted from Der f) in a dose progressive manner and long-term sublingual administration. Methods: To sensitize the guinea pigs, the protein antigen emulsified in aluminium hydroxide gel was subcutaneously and intraperitoneally injected. To observe early-phase reaction of asthma, lung resistance (RL) and lung dynamic compliance (Cdyn) in the sensitized guinea pigs were determined by intravenously injecting antigen. To observe late-phase reaction of asthma, the sensitized guinea pigs were challenged with aerosolized antigen for 7 days. Subsequently, methacholine (Mch) in a cumulative dose-manner induced-airway hyperreactivity (AHR), inflammatory cells numbers in bronchoalveolar lavage fluid (BALF) and pathological changes of lung tissue were measured in the model. From the first day of sensitization, the guinea pigs in treatment group sublingually received DMD in a dose progressive manner. The model group sublingually received equivalent saline. The normal control group did not receive any treatment. Results: The guinea pigs in model group showed a significant increase in RL and decrease in Cdyn, and developed a marked AHR to Mch. The number of total leukocytes and eosinophils increased significantly in BALF. Serious infiltration of eosinophils was observed in pathological section of lung tissue. Compared with model group, DMD treatment group exhibited a significant amelioration for early-phase and late-phase reaction of asthma. Conclusion: DMD in a dose progressive manner and long-term sublingual administration displays a significant desensitization on Der f antigen-specific asthmatic reaction. The results provided experimental evidence for clinical therapy.
KW - animal models
KW - antigens
KW - asthma
KW - bronchoalveolar lavage
KW - eosinophils
KW - house dust mites
KW - hypersensitivity
KW - immune desensitization
KW - leukocytes
KW - lungs
KW - Dermatophagoides farinae
KW - guineapigs
KW - mites
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - allergic responses
KW - antigenicity
KW - eosinophil leukocytes
KW - guinea pigs
KW - house-dust mites
KW - housedust mites
KW - hypersensitiveness
KW - hyposensitization
KW - immunogens
KW - leucocytes
KW - methacholine
KW - white blood cells
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063221024&site=ehost-live&scope=site
UR - http://www.cpa.org.cn
UR - email: chenjq@zju.edu.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection.
AU - Ijaz, K.
AU - Jereb, J. A.
AU - Lambert, L. A.
AU - Bower, W. A.
AU - Spradling, P. R.
AU - McElroy, P. D.
AU - Iademarco, M. F.
AU - Navin, T. R.
AU - Castro, K. G.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006///
VL - 42
IS - 3
SP - 346
EP - 355
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Ijaz, K.: Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Rd., E-10, Atlanta, GA 30333, USA.
N1 - Accession Number: 20063069427. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 98-96-4, 13292-46-1. Subject Subsets: Public Health
N2 - Background. Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection. Implicating RZ as the likeliest cause required excluding alternative causes. Methods. US health departments reported data on patients who died or were hospitalized for liver disease within 1 month after taking RZ for latent tuberculosis infection from October 1998 through March 2004. The circumstances were investigated on site for each case. Illness characteristics, reasons for RZ treatment, doses and frequency of administration of pyrazinamide, monitoring during treatment, and causes of liver injury were determined. Results. Liver injury was attributable to RZ use for all 50 patients reported, 12 of whom died. For 47 patients, RZ was the likeliest cause of liver injury. The median patient age was 44 years (range, 17-73 years). Thirty-two patients (64%) were male. Seven (16%) of 43 patients tested had hepatitis C virus antibodies, 1 (2%) of 45 had chronic hepatitis B, 3 (14%) of 22 had positive results of HIV serologic tests, 34 (71%) of 48 had alcohol use noted, and 33 (66%) of 50 were taking additional hepatotoxic medications. Six patients, 2 of whom died, had no predictors for liver disease. Patients who died were older (median age, 52 vs. 42 years; P=.08) and took a greater number of other medications (median number of medications, 4 vs. 2; P=.05) than did those who recovered, but these 2 factors were correlated (P<.01). Thirty-one patients (62%) were monitored according to guidelines, 9 of whom died. Conclusions. RZ was the likeliest cause of most of these liver injuries, some of which were fatal in spite of monitoring. Fatality was predicted by age or use of other medications, but none of the cofactors showed promise as a reliable clinical predictor of severe liver injury.
KW - adverse effects
KW - antituberculous agents
KW - drug therapy
KW - human diseases
KW - latent infections
KW - liver
KW - liver diseases
KW - pyrazinamide
KW - rifampicin
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterium
KW - chemotherapy
KW - rifampin
KW - rifamycin amp
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063069427&site=ehost-live&scope=site
UR - email: kijaz@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting.
AU - White, P. L.
AU - Linton, C. J.
AU - Perry, M. D.
AU - Johnson, E. M.
AU - Barnes, R. A.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006///
VL - 42
IS - 4
SP - 479
EP - 486
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - White, P. L.: Department of Medical Microbiology, National Public Health Service Cardiff, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
N1 - Accession Number: 20063084035. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Background. Invasive aspergillosis (IA) is associated with high mortality. Successful outcome with treatment is linked to early diagnosis. The utility of classic diagnostic methods, however, is limited. Methods. To aid in the diagnosis of IA, we retrospectively assessed our diagnostic service, using real-time polymerase chain reaction (PCR) and galactomannan sandwich enzyme-linked immunosorbent assay (ELISA). Results. A total of 203 patients at risk of invasive fungal infection were screened by PCR, and 116 of the patients were also tested by ELISA. The patient group comprised 176 patients with hematological malignancy and 28 control patients with evidence of invasive candidal infection. Consensus European Organisation for Research and Treatment of Cancer and Mycoses Study Group criteria were used to classify fungal infection, which, by definition, excluded the PCR result. The PCR method was sensitive (up to 92.3% sensitivity) and specific (up to 94.6% specificity) and had good agreement with the galactomannan ELISA (76.7%) and high-resolution computed tomography scan results. Conclusions. A negative PCR result can be used to rule out IA and to limit the need for empirical antifungal therapy; thus, it has a role in diagnosing IA infections, especially in combination with antigen testing. PCR-positive cases classified as "false positives" regularly reflect the limitations of classic microbiological procedures or restricted use of consensus clinical methods employed to classify infection.
KW - aspergillosis
KW - assays
KW - blood disorders
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - polymerase chain reaction
KW - Aspergillus
KW - man
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - blood diseases
KW - fungus
KW - haematologic disorders
KW - hematologic disorders
KW - Hyphomycetes
KW - PCR
KW - sensitivity and specificity
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063084035&site=ehost-live&scope=site
UR - email: Lewis.White@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Update on vaccine liability in the United States: presentation at the national vaccine program office workshop on strengthening the supply of routinely recommended vaccines in the United States, 12 February 2002.
AU - Evans, G.
A2 - Klein, J. O.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006///
VL - 42
SP - S130
EP - S137
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Evans, G.: National Vaccine Injury Compensation Program, Health Resources and Services Administration, Department of Health and Human Services, 5600 Fishers Ln., Rm. 11C-26, Rockville, MD 20857, USA.
N1 - Accession Number: 20063109454. Publication Type: Journal Article; Conference paper; Journal article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health; Plant Breeding; World Agriculture, Economics & Rural Sociology
N2 - Two decades ago, a liability crisis brought on by concerns about the safety of diphtheria and tetanus toxoids and pertussis vaccine led to supply shortages and calls for rationing of the vaccine. Vaccine prices skyrocketed, and research on new products was threatened. In response, Congress created the National Vaccine Injury Compensation Program, which is tort reform legislation designed to compensate individuals quickly, easily, and generously. Since 1988, the Vaccine Injury Compensation Program has stabilized the marketplace, as evidenced by high immunization rates, stable pricing, and an increasing number of vaccine candidates in development. Although current vaccine shortages do not appear to be related to issues of liability, a new wave of tort litigation alleging that some vaccines cause autism has led to speculation that history could repeat itself.
KW - immunization
KW - law
KW - supplies
KW - vaccination
KW - vaccines
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immune sensitization
KW - legal aspects
KW - legal principles
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Policy and Planning (EE120)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063109454&site=ehost-live&scope=site
UR - email: gevans@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Childhood asthma prevalence in northern Puerto Rico, the Rio Grande, and Loíza experience.
AU - Loyo-Berríos, N. I.
AU - Orengo, J. C.
AU - Serrano-Rodríguez, R. A.
JO - Journal of Asthma
JF - Journal of Asthma
Y1 - 2006///
VL - 43
IS - 8
SP - 619
EP - 624
CY - New York; USA
PB - Informa Healthcare
SN - 0277-0903
AD - Loyo-Berríos, N. I.: Food and Drug Administration, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Post-Market Surveillance, Epidemiology Branch, Rockville, Maryland, USA.
N1 - Accession Number: 20083043727. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Tropical Diseases
N2 - Objective. Childhood asthma is highly prevalent in some areas of Puerto Rico. The objective of this study was to estimate the prevalence of asthma in two municipalities of Northern Puerto Rico. Methods. Children 6 to 7 and 13 to 14 years of age participated in the school-based cross-sectional study. Results. A total of 1,467 elementary school students and 1,334 junior-high school students were included in the survey. A high prevalence of asthma was observed; 46% in elementary schools and 24% in junior-high schools. In elementary schools, family history of asthma (FHA) was associated with ever wheezed (PR=2.00, 95%CI 1.59, 2.52), wheeze during last year (PR=2.02, 95%CI 1.54, 2.62), and asthma (PR=2.33, 95%CI 1.86, 2.92). For junior-high schools FHA was associated with ever wheezed (PR=2.01, 95%CI 1.56, 2.57), wheeze during previous year (PR=2.00, 95%CI 1.47, 2.73), and asthma (PR=2.72, 95%CI 2.06, 3.60). Conclusions. This study showed a high prevalence of asthma and related symptoms in Northern Puerto Rico. FHA was strongly associated with asthma and its symptoms. Further research is recommended to look at genetics, sensitivity levels, indoor and outdoor pollution, and gene-environment interactions.
KW - asthma
KW - children
KW - disease prevalence
KW - epidemiology
KW - familial incidence
KW - high school students
KW - human diseases
KW - risk factors
KW - school children
KW - Puerto Rico
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - Porto Rico
KW - school kids
KW - schoolchildren
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083043727&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a759144653~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The characterization of airborne occupational safety and health hazards in selected small businesses; manufacturing wood pallets.
AU - Malkin, R.
AU - Lentz, T. J.
AU - Topmiller, J.
AU - Hudock, S. D.
AU - Niemeier, R. W.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006///
VL - 44
IS - 1
SP - 58
EP - 63
CY - Kawasaki; Japan
PB - National Institute of Industrial Health
SN - 0019-8366
AD - Malkin, R.: National Institute for Occupational Safety and Health, Education and Information Division, Ohio, USA.
N1 - Accession Number: 20063131768. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 630-08-0. Subject Subsets: Agricultural Engineering; Forestry; Forest Products
N2 - Researchers from the National Institute for Occupational Safety and Health (NIOSH) investigated occupational safety and health of workers in small business wood pallet manufacturing industry because of an injury rate of 226% in 2000, which is greater than that of the other industries. NIOSH investigators conducted walk-in evaluations at seven wood pallet manufacturing companies within the vicinity of their office in Cincinnati, Ohio, USA, and returned to four of them to take environmental measurements. Carbon monoxide (CO) levels, noise levels, and total particulate were measured; ergonomic observations were made; and occupational safety practices were analysed at each of the four facilities where measurements were taken. The focus of this study is the evaluation of airborne particulate and carbon monoxide exposures to identify areas of potentially high exposures. This knowledge can guide the plant owner or health professional in determining whether further measurements are necessary and where they might be needed. Safety factors and physical stressors (noise and ergonomic stressors) were described in a previously published companion paper. Although we did not take 8 h samples, we did find certain exposures that might be important to small business owners. The main findings of this investigation were as follows: CO levels in three plants were less than the OSHA permissible exposure limit (PEL) of 50 parts per million (ppm) for an 8-h TWA. Three measurements, all from one plant, with old and defective fork lift were above 50 ppm. Total dust measures ranged from 0.86 to 1.67 mg/m3, taken adjacent to an operating machine cutting hardwood and measured up to 6 minutes. The American Conference of Governmental Industrial Hygienists guideline for hardwood dust is 1.0 mg/m3 for an 8-h TWA.
KW - carbon monoxide
KW - characterization
KW - dust
KW - ergonomics
KW - fork lifts
KW - manufacture
KW - noise
KW - occupational hazards
KW - occupational health
KW - pallets
KW - safety at work
KW - saws
KW - small businesses
KW - trauma
KW - ventilation
KW - wood products
KW - Ohio
KW - USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - human engineering
KW - occupational safety
KW - traumas
KW - United States of America
KW - Forestry Economics (EE112) (New March 2000)
KW - Rural Industry and Enterprises (EE350)
KW - Wood Utilization and Engineered Wood Products (KK520)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Occupational Health and Safety (VV900)
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UR - http://www.niih.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of aminopentol on in utero development in rats.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Olejnik, N.
AU - Eppley, R. M.
AU - Shackelford, M. E.
AU - Howard, P. C.
AU - Rorie, J. I.
AU - Bryant, M.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 2
SP - 161
EP - 169
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063029225. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Aminopentol (AP1), the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), is present in corn-based foods which are consumed daily as a substantial part of the diet in some areas of the world. The toxicity of FB1 has been attributed to altered sphingolipid metabolism, but the toxicity of AP1 is less certain. Epidemiological correlations and in vitro studies have suggested that AP1 can increase neural tube defects (NTDs), but no in vivo developmental study of AP1 was done prior to this study. AP1 was given once daily to rats by gavage on gestation days (GD) 3-16 at doses of 0, 15, 30, 60, or 120 mg/kg. Reproductive and developmental parameters were measured at GD 17, one day after the last dose, and on GD 20. In addition, on GD 17, maternal and fetal tissues were analyzed for sphingolipid content. Conclusions: AP1 reduced dam body weight gain, but was less toxic than FB1. AP1 was not teratogenic, did not affect tissue sphingolipid ratios, did not alter reproduction or development of fetuses, and produced no dose-related histopathological effects in dams.
KW - animal models
KW - embryonic development
KW - fetal development
KW - fumonisins
KW - laboratory animals
KW - prenatal development
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aminopentol
KW - embryo development
KW - embryo growth
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063029225&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: tcollins@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E2 and C-reactive protein in serum and livers of pregnant and non-pregnant female rats.
AU - Wiesenfeld, P. W.
AU - Sapienza, P. P.
AU - Flynn, T. J.
AU - Ford, C. E.
AU - Ross, I. A.
AU - Sahu, S.
AU - Kim, C. S.
AU - O'Donnell, M. W., Jr.
AU - Collins, T. F. X.
AU - Sprando, R. L.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 4
SP - 579
EP - 587
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Wiesenfeld, P. W.: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063070719. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 63-05-8, 56-65-5, 9007-41-4, 25167-62-8, 11000-26-3. Subject Subsets: Human Nutrition
N2 - Androstenedione, a steroidal dietary supplement taken to enhance athletic performance, could affect serum and liver lipid metabolism, induce liver toxicity or alter inflammatory response depending on dose and duration of exposure. Pregnancy could further exaggerate these effects. To examine this, mature female rats were gavaged with 0, 5, 30 or 60 mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60 mg/kg/day androstenedione. Serum was collected and livers were removed from dams on gestation day 20 and from non-pregnant rats after 5 weeks of treatment. Androstenedione had no effect on serum total cholesterol, triglycerides or HDL-cholesterol, but significantly decreased C-reactive protein in pregnant rats and prostaglandin E2 in serum of both pregnant and non-pregnant rats. There were treatment related decreases in liver ATP and, to a lesser degree, caspase-3 and no change in alkaline phosphatase of pregnant female rats. Androstenedione decreased docosahexaenoic acid in both serum and liver phospholipids of pregnant female rats. In conclusion, oral androstenedione did not result in overt hepatotoxicity in pregnant female rats, but produced modest changes in lipid metabolism and may impair regeneration of injured hepatic cells or tissue.
KW - androstenedione
KW - animal models
KW - ATP
KW - blood serum
KW - C-reactive protein
KW - docosahexaenoic acid
KW - food supplements
KW - laboratory animals
KW - lipid metabolism
KW - liver
KW - phospholipids
KW - pregnancy
KW - prostaglandins
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adenosine triphosphate
KW - caspase-3
KW - fat metabolism
KW - gestation
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063070719&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: pwiesenf@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Olejnik, N.
AU - Eppley, R. M.
AU - Hines, F. A.
AU - Rorie, J.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 6
SP - 747
EP - 757
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063108060. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Registry Number: 51481-10-8. Subject Subsets: Medical & Veterinary Mycology
N2 - Deoxynivalenol (DON, vomitoxin), is one of the most common contaminants of cereal grains world-wide. The effects of DON on fetal development were assessed in Charles River Sprague-Dawley rats. Pregnant female rats were gavaged once daily with DON at doses of 0, 0.5, 1, 2.5, or 5 mg/kg body weight on gestation days (GD) 6-19. At cesarean section on GD 20, reproductive and developmental parameters were measured. All females survived to cesarean section. DON caused a dose-related increase in excessive salivation by the pregnant females, a reaction probably linked to the lack of emetic reflex in rats. At 5 mg/kg, feed consumption and mean body weight gain were significantly decreased throughout gestation, mean weight gain (carcass weight), and gravid uterine weight were significantly reduced, 52% of litters (12/23) were totally resorbed, the average number of early and late deaths per litter was significantly increased, average fetal body weight and crown-rump length were significantly decreased, the incidence of runts was significantly increased, and the ossification of fetal sternebrae, centra, dorsal arches, vertebrae, metatarsals, and metacarpals was significantly decreased. At 2.5 mg/kg, DON significantly decreased average fetal body weight, crown-rump length, and vertebral ossification. These effects may be secondary to maternal toxicity and the reduced size of the fetuses. The incidence of misaligned and fused sternebrae was significantly increased at 5.0 mg/kg. No adverse developmental effects were observed at 0.5 and 1.0 mg/kg. Dose-related increases in maternal liver weight-to-body weight ratios were observed in all treated groups (significant at 1, 2.5, and 5 mg/kg). The weight changes were correlated with dose-related cytoplasmic alterations of hepatocytes. The NOEL for maternal toxicity for this study is 0.5 mg/kg based on the dose-related increase in liver-body weight ratio at 1 mg/kg. The NOEL for fetal toxicity is 1 mg/kg based on the general reduction in fetal development at 2.5 and 5 mg/kg. DON is considered a teratogen at 5 mg/kg day in Sprague-Dawley rats based on the anomalous development of the sternebrae.
KW - animal models
KW - biological development
KW - body weight
KW - bones
KW - caesarean section
KW - cereals
KW - female animals
KW - fetus
KW - food contamination
KW - laboratory animals
KW - liver
KW - liver cells
KW - metacarpus
KW - metatarsus
KW - ossification
KW - pregnancy
KW - runting
KW - salivation
KW - survival
KW - teratogens
KW - toxicity
KW - uterus
KW - vomitoxin
KW - weight gain
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxynivalenol
KW - foetus
KW - food contaminants
KW - gestation
KW - hepatocytes
KW - vertebrae
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063108060&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: tcollins@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of multilocus sequence typing, pulsed-field gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates.
AU - Harbottle, H.
AU - White, D. G.
AU - McDermott, P. F.
AU - Walker, R. D.
AU - Zhao, S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2006///
VL - 44
IS - 7
SP - 2449
EP - 2457
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Harbottle, H.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20063160315. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 80370-57-6, 1403-66-3, 1405-41-0, 8063-07-8, 57-92-1, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Veterinary Science; Public Health; Veterinary Science; Pig Science
N2 - In the United States, multidrug-resistant phenotypes of Salmonella enterica serotype Newport (commonly referred to as MDR-AmpC) have emerged in animals and humans and have become a major public health problem. Although pulsed-field gel electrophoresis (PFGE) is the current "gold standard" typing method for Salmonella, multilocus sequence typing (MLST) may be more relevant to investigations exploring evolutionary and population biology relationships. In this study, 81 Salmonella enterica serotype Newport isolates from humans, food animals, and retail foods were examined for antimicrobial susceptibility and characterized using PFGE and MLST of seven genes, aroC, dnaN, hemD, hisD, purE, sucA, and thrA. Forty-nine percent of the isolates were resistant to nine or more of the tested antimicrobials. Salmonella isolates displayed resistance most often to sulfamethoxazole (57%), streptomycin (56%), tetracycline (56%), ampicillin (52%), and ceftiofur (49%) and, to a lesser extent, to kanamycin (19%), trimethoprim-sulfamethoxazole (17%), and gentamicin (11%). A total of 43 PFGE patterns were generated using XbaI, indicating a genetically diverse population. The largest PFGE cluster contained isolates from clinically ill swine, cattle, and humans. MLST resulted in 12 sequence types (STs), with one type encompassing 62% of the strains. Ten new sequence types and one novel allele type were identified. Furthermore, MLST typing showed that strains closely related by PFGE clustered in major STs, whereas more distantly related strains were separated into two clusters by PFGE. The results of this study demonstrated that the MLST scheme employed here clustered S. enterica serovar Newport isolates in distinct molecular populations, and strain discrimination was enhanced by combining PFGE, antimicrobial susceptibility, and MLST results.
KW - ampicillin
KW - analytical methods
KW - antibacterial agents
KW - ceftiofur
KW - drug susceptibility
KW - gentamicin
KW - human diseases
KW - kanamycin
KW - molecular biology
KW - molecular genetics
KW - molecular genetics techniques
KW - multiple drug resistance
KW - pulsed field electrophoresis
KW - resistance mechanisms
KW - salmonellosis
KW - streptomycin
KW - sulfamethoxazole
KW - tetracycline
KW - trimethoprim
KW - zoonoses
KW - man
KW - Salmonella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - achromycin
KW - analytical techniques
KW - bacterium
KW - biochemical genetics
KW - Salmonella infections
KW - sulphamethoxazole
KW - zoonotic infections
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063160315&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: heather.harbottle@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats.
AU - Culp, S. J.
AU - Mellick, P. W.
AU - Trotter, R. W.
AU - Greenlees, K. J.
AU - Kodell, R. L.
AU - Beland, F. A.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 8
SP - 1204
EP - 1212
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Culp, S. J.: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063147568. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 569-64-2. Subject Subsets: Medical & Veterinary Mycology
N2 - Malachite green is a triphenylmethane dye used in the fish industry as an anti-fungal agent. Leucomalachite green is formed by the metabolic reduction of malachite green and persists in the tissues of exposed fish. In this study, we examined the carcinogenicity of malachite green chloride and leucomalachite green. Female F344 rats (48 per group) were fed diets containing 0, 100, 300, or 600 ppm malachite green chloride for 104 weeks, at which time the extent of tumorigenesis was assessed. Additional groups of 48 female and 48 male F344 rats were fed diets containing 0, 91, 272, or 543 ppm leucomalachite green for 104 weeks. Groups of 48 female B6C3F1 mice were fed diets containing 0, 100, 225, or 450 ppm malachite green chloride or 0, 91, 204, or 408 ppm leucomalachite green for 104 weeks. For each of the exposures, food consumption in the treatment groups was similar to the controls. Rats fed malachite green chloride or leucomalachite green had dose-dependent reductions in body weight; in mice, there were no consistent effects upon body weights with either compound. Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma. Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia. In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis. There were no treatment-related neoplasms in female B6C3F1 mice fed malachite green chloride. Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group.
KW - adenoma
KW - animal models
KW - antifungal agents
KW - body weight
KW - breast
KW - breast cancer
KW - carcinogenesis
KW - carcinogens
KW - carcinoma
KW - drug residues
KW - leukaemia
KW - liver
KW - liver cancer
KW - malachite green
KW - neoplasms
KW - pituitary
KW - testes
KW - testicular cancer
KW - thyroid cancer
KW - thyroid gland
KW - mice
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood cancer
KW - breasts
KW - cancers
KW - fungistats
KW - hypophysis
KW - leucaemia
KW - leucomalachite green
KW - leukemia
KW - pituitary cancer
KW - pituitary gland
KW - testicles
KW - thyroid
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063147568&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: frederick.beland@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of zearalenone on in utero development in rats.
AU - Collins, T. F. X.
AU - Sprando, R. L.
AU - Black, T. N.
AU - Olejnik, N.
AU - Eppley, R. M.
AU - Alam, H. Z.
AU - Rorie, J.
AU - Ruggles, D. I.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 9
SP - 1455
EP - 1465
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Collins, T. F. X.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20063153764. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 9002-68-0, 9002-67-9, 57-83-0, 9002-62-4, 17924-92-4, 50-28-2. Subject Subsets: Medical & Veterinary Mycology
N2 - Zearalenone (ZE), an estrogenic mycotoxin produced by Fusarium graminearum or F. roseum, is one of the most common contaminants of cereal grains world-wide. The objective of this study was to determine the effects of ZE on in utero development of rats. Pregnant female Charles River Sprague-Dawley rats were gavaged once daily with ZE (in corn oil) at doses of 0, 1, 2, 4, or 8 mg/kg body weight on gestation days (GD) 6-19. All females survived to cesarean section on GD 20. At cesarean section, reproductive and developmental parameters were measured and blood was taken for hormone analysis. Dose-related decreases were seen in maternal feed consumption and body weight gain in all treated groups. Delayed fetal development was linked to maternal toxicity. Fetal body weight was significantly decreased in both sexes in all treated groups. ZE retarded skeletal ossification at 4 and 8 mg/kg. Fetal anogenital index (anogenital distance normalized for body weight) was increased in all treated groups, indicating an androgenic effect of ZE during fetal development. Fetal viability was significantly decreased at 8 mg/kg; significant decreases were observed in number of viable fetuses, and number of litters totally resorbed. At 4 and 8 mg/kg, maternal liver-body weight ratios were significantly increased and organ-brain weight ratios for weights of liver, heart, spleen, kidneys, and ovaries were significantly decreased. Gonadotropins (LH, FSH, and prolactin) and sex steroids (progesterone and estradiol) were analyzed from the blood serum obtained at cesarean section. LH in the 0, 1, 2, and 4 mg/kg groups showed minimal variation, and slightly increased at 8 mg/kg. FSH was decreased in the 1, 2, and 4 mg/kg groups, but the level at 8 mg/kg was slightly higher than the control level. Prolactin level was not affected at 1 mg/kg, slightly increased at 2 and 4 mg/kg, and significantly increased at 8 mg/kg. Progesterone was decreased at 2, 4, and 8 mg/kg and the decreases were significant at 2 and 4 mg/kg. Estradiol level was not affected at 1 mg/kg, but dose-related decreases were observed at 2, 4, and 8 mg/kg. Only the 8 mg/kg level of estradiol was significantly decreased. In summary, ZE was maternally toxic and fetotoxic but not teratogenic. The increased anogenital distance observed in male and female fetuses was considered a hormonal change rather than a teratologic response. The increased anogenital distance indicated an androgenic effect. Based on the dose-related maternal and fetal toxicity in all treated groups, the NOEL for reproductive and teratogenic effects was less than 1 mg/kg.
KW - animal models
KW - bone formation
KW - brain
KW - estradiol
KW - females
KW - fetal development
KW - FSH
KW - heart
KW - kidneys
KW - laboratory animals
KW - LH
KW - liver
KW - males
KW - mycotoxins
KW - oestrogenic properties
KW - ovaries
KW - prenatal development
KW - progesterone
KW - prolactin
KW - spleen
KW - toxicity
KW - toxicology
KW - zearalenone
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bone calcification
KW - cerebrum
KW - estrogenic properties
KW - f-2 toxin
KW - follicle stimulating hormone
KW - follitropin
KW - fungal toxins
KW - lactogenic hormone
KW - luteinizing hormone
KW - mammotropin
KW - oestradiol
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063153764&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: tcollins@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures.
AU - Sahu, S. C.
AU - Ruggles, D. I.
AU - O'Donnell, M. W.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2006///
VL - 44
IS - 10
SP - 1751
EP - 1757
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Sahu, S. C.: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063173851. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 500-38-9. Subject Subsets: Human Nutrition; Horticultural Science
N2 - Nordihydroguaiaretic acid (NDGA) is a polyphenol. It is present at high concentrations in the leaves of the evergreen desert shrub, Larrea tridentate (Creosote bush), which has a long history of medicinal use traditionally by the native Americans and Mexicans. It is generally believed that the antioxidant properties of NDGA are responsible for the medicinal value of this desert shrub. The clone-9 rat hepatocyte cultures were used as an in vitro model to assess the hepatotoxic potential of NDGA and to determine whether it exhibits any prooxidant activity. The hepatocyte cultures were treated with NDGA for 2 h at 37°C at concentrations of 0-100 µM. After the treatment period the cells, the culture supernatants and cell lysates were assayed for evaluation of prooxidant activity and toxicity of NDGA. Oxidative stress level and oxidative cell injury as measured by the peroxidation of membrane lipids and DNA double-strand breaks were used to index prooxidant activity. Cytotoxicity as measured by the leakage of the liver enzyme lactate dehydrogenase (LDH) into the culture medium, mitochondrial function and extent of cell proliferation were used as the endpoints of toxicity. Significant concentration-dependent differences were observed in these biomarkers over the concentration range examined demonstrating the prooxidant activity and toxicity of NDGA in clone-9 rat hepatocyte cultures.
KW - animal models
KW - antioxidant properties
KW - hepatotoxins
KW - laboratory animals
KW - liver cells
KW - nordihydroguaiaretic acid
KW - Larrea tridentata
KW - rats
KW - Larrea
KW - Zygophyllaceae
KW - Sapindales
KW - Geraniales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - anti-oxidant properties
KW - hepatocytes
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063173851&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: saura.sahu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri.
AU - Qvarnstrom, Y.
AU - Visvesvara, G. S.
AU - Sriram, R.
AU - Silva, A. J. da
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2006///
VL - 44
IS - 10
SP - 3589
EP - 3595
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Qvarnstrom, Y.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4700 Buford Highway NE, Mail Stop F36, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20063216568. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Tropical Diseases; Public Health; Protozoology
N2 - Infections caused by Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris occur throughout the world and pose many diagnostic challenges. To date, at least 440 cases of severe central nervous system infections caused by these amebas have been documented worldwide. Rapid and specific identification of these free-living amebas in clinical samples is of crucial importance for efficient case management. We have developed a triplex real-time TaqMan PCR assay that can simultaneously identify Acanthamoeba spp., B. mandrillaris, and N. fowleri in the same PCR vessel. The assay was validated with 22 well-characterized amebic strains harvested from cultures and nine clinical specimens that were previously characterized by in vitro culture and/or immunofluorescence assay. The triplex assay demonstrated high specificity and a rapid test completion time of less than 5 h from the reception of the specimen in the laboratory. This assay was able to detect one single ameba per sample analyzed, as determined with cerebrospinal fluid spiked with diluted cultured amebas. This assay could become useful for fast laboratory diagnostic assessment of amebic infections (caused by free-living amebas) in laboratories with adequate infrastructure to perform real-time PCR testing.
KW - amoebiasis
KW - central nervous system
KW - detection
KW - human diseases
KW - in vitro
KW - methodology
KW - polymerase chain reaction
KW - protozoal infections
KW - Acanthamoeba
KW - man
KW - Naegleria fowleri
KW - Acanthamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Naegleria
KW - Vahlkampfiidae
KW - Schizopyrenida
KW - amebiasis
KW - Balamuthia
KW - Balamuthia mandrillaris
KW - CNS
KW - methods
KW - PCR
KW - protozoal diseases
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063216568&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: abs8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotyping of measles virus in clinical specimens on the basis of oligonucleotide microarray hybridization patterns.
AU - Neverov, A. A.
AU - Riddell, M. A.
AU - Moss, W. J.
AU - Volokhov, D. V.
AU - Rota, P. A.
AU - Lowe, L. E.
AU - Chibo, D.
AU - Smit, S. B.
AU - Griffin, D. E.
AU - Chumakov, K. M.
AU - Chizhikov, V. E.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2006///
VL - 44
IS - 10
SP - 3752
EP - 3759
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Neverov, A. A.: HFM-470, LMD/Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20063216590. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - An oligonucleotide microarray hybridization method for identification of most known measles virus (MV) genotypes was developed. Like the conventional genotyping method, the microarray relied on detecting sequence differences in the 450-nucleotide region coding for the COOH-terminal 150 amino acids of the nucleoprotein (N). This region was amplified using PCR primers binding to all known MV genotypes. The microarray included 71 pairs of oligonucleotide probes (oligoprobes) immobilized on glass slides. Each pair consisted of a genotype-specific oligoprobe, which matched the sequence of only one target genotype, and a control oligoprobe, which contained mismatches at the nucleotide positions unique to this genotype. A pattern recognition algorithm based on cluster analysis of the ratios of hybridization signals from specific and control oligoprobes was used to identify the specific MV genotype. Following the initial validation, the method was used for rapid genotyping of two panels of coded samples. The results of this study showed good sensitivity (90.7%), specificity (100%), and genotype agreement (91.8%) for the new method compared to the results of genotyping conducted using phylogenetic analysis of viral sequences of the C terminus of the N gene. In addition, the microarray demonstrated the ability to identify potential new genotypes of MV based on the similarity of their hybridization patterns with those of known MV genotypes.
KW - DNA microarrays
KW - genes
KW - genotypes
KW - human diseases
KW - measles
KW - nucleotide sequences
KW - oligonucleotides
KW - man
KW - Measles virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - DNA sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063216590&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: alexander.neverov@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Airborne fungal fragments and allergenicity.
AU - Green, B. J.
AU - Tovey, E. R.
AU - Sercombe, J. K.
AU - Blachere, F. M.
AU - Beezhold, D. H.
AU - Schmechel, D.
A2 - Steinbach, W. J.
A2 - Stevens, D. A.
A2 - Clemons, K. V.
A2 - Latgé, J. P.
A2 - Moss, R. B.
JO - Medical Mycology
JF - Medical Mycology
Y1 - 2006///
VL - 44
SP - S245
EP - S255
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1369-3786
AD - Green, B. J.: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M.S. 4020, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20063238549. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 82 ref. Registry Number: 37341-29-0. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Exposure to fungi, particularly in water damaged indoor environments, has been thought to exacerbate a number of adverse health effects, ranging from subjective symptoms such as fatigue, cognitive difficulties or memory loss to more definable diseases such as allergy, asthma and hypersensitivity pneumonitis. Understanding the role of fungal exposure in these environments has been limited by methodological difficulties in enumerating and identifying various fungal components in environmental samples. Consequently, data on personal exposure and sensitization to fungal allergens are mainly based on the assessment of a few select and easily identifiable species. The contribution of other airborne spores, hyphae and fungal fragments to exposure and allergic sensitization are poorly characterized. There is increased interest in the role of aerosolized fungal fragments following reports that the combination of hyphal fragments and spore counts improved the association with asthma severity. These fragments are particles derived from any intracellular or extracellular fungal structure and are categorized as either submicron particles or larger fungal fragments. In vitro studies have shown that submicron particles of several fungal species are aerosolized in much higher concentrations (300-500 times) than spores, and that respiratory deposition models suggest that such fragments of Stachybotrys chartarum may be deposited in 230-250 fold higher numbers than spores. The practical implications of these models are yet to be clarified for human exposure assessments and clinical disease. We have developed innovative immunodetection techniques to determine the extent to which larger fungal fragments, including hyphae and fractured conidia, function as aeroallergen sources. These techniques were based on the Halogen Immunoassay (HIA), an immunostaining technique that detects antigens associated with individual airborne particles >1 µm, with human serum immunoglobulin E (IgE). Our studies demonstrated that the numbers of total airborne hyphae were often significantly higher in concentration than conidia of individual allergenic genera. Approximately 25% of all hyphal fragments expressed detectable allergen and the resultant localization of IgE immunostaining was heterogeneous among the hyphae. Furthermore, conidia of ten genera that were previously uncharacterized could be identified as sources of allergens. These findings highlight the contribution of larger fungal fragments as aeroallergen sources and present a new paradigm of fungal exposure. Direct evidence of the associations between fungal fragments and building-related disease is lacking and in order to gain a better understanding, it will be necessary to develop diagnostic reagents and detection methods, particularly for submicron particles. Assays using monoclonal antibodies enable the measurement of individual antigens but interpretation can be confounded by cross-reactivity between fungal species. The recent development of species-specific monoclonal antibodies, used in combination with a fluorescent-confocal HIA technique should, for the first time, enable the speciation of morphologically indiscernible fungal fragments. The application of this novel method will help to characterize the contribution of fungal fragments to adverse health effects due to fungi and provide patient-specific exposure and sensitization profiles.
KW - allergens
KW - analytical methods
KW - bronchial asthma
KW - conidia
KW - human diseases
KW - hyphae
KW - IgE
KW - immune response
KW - immunoassay
KW - techniques
KW - analytical techniques
KW - immunity reactions
KW - immunological reactions
KW - reagin
KW - reaginic antibodies
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063238549&site=ehost-live&scope=site
UR - http://journalsonline.tandf.co.uk/link.asp?id=101351
UR - email: Brett.Green@cdc.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusion.
AU - Rios, M.
AU - Zhang, M. J.
AU - Grinev, A.
AU - Srinivasan, K.
AU - Daniel, S.
AU - Wood, O.
AU - Hewlett, I. K.
AU - Dayton, A. I.
JO - Transfusion
JF - Transfusion
Y1 - 2006///
VL - 46
IS - 4
SP - 659
EP - 667
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Rios, M.: Laboratory of Molecular Virology (LMV), Division of Emerging Transfusion Transmitted Diseases (DETTD), Office of Blood Research and Review (OBRR), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 8800 Rockville Pike Bethesda, MD 20892, USA.
N1 - Accession Number: 20073008290. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - BACKGROUND: West Nile virus (WNV) transmission by transfusion was documented in 2002. Approximately 80 percent of WNV infections are asymptomatic and 1 percent develop severe neurological illness. In animals, Langerhans-dendritic cells support initial viral replication, followed by replication in lymphoid tissues and dissemination to organs and possibly to the CNS. The cellular tropism of WNV infection after transfusion and the particular human blood cells that sustain viral replication remain largely unknown. Whether primary monocyte-derived macrophages (MDMs) support WNV infection-replication and produce infectious virions, with an in vitro system, was investigated. STUDY DESIGN AND METHODS: Elutriated monocytes (CD33+/CD14+) from suitable blood donors were cultured in the presence of macrophage-colony-stimulating factor, infected with WNV-NY99 at different time points, washed, and cultivated for up to 47 days. Supernatants were tested for WNV replication by TaqMan reverse transcription-polymerase chain reaction (RT-PCR), with primers for the envelope and/or 3′NC regions, and by cDNA-PCR to detect WNV minus-strand RNA and for the presence of functional virions by infectivity assays in Vero cells. RESULTS: RT-PCR TaqMan of supernatants demonstrated productive infection of MDMs. Viral load reached 2 to 5 log above baseline in 3 to 6 days and then declined, with detectable viral replication persisting for up to 47 days. WNV minus-strand RNA was detected in Day 4 cultures, indicating active viral replication. Infected MDM cultures showed no cytopathic changes. Supernatants that were TaqMan-positive for the presence of WNV-infected Vero cells and produced cytopathic effects within 3 to 5 days of culture. CONCLUSION: The susceptibility of monocytes-macrophages to productive infection in vitro is compatible with a potential role in initial WNV replication and propagation after transmission by transfusion.
KW - blood donors
KW - blood transfusion
KW - cell cultures
KW - disease transmission
KW - in vitro
KW - infections
KW - macrophages
KW - monocytes
KW - viral load
KW - viral replication
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073008290&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=trf
UR - email: maria.rios@fda.hhs.gov\andrew.dayton@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety.
AU - Srinivasan, K.
AU - Akolkar, P. N.
AU - Taffs, R. E.
AU - Hewlett, I. K.
JO - Transfusion
JF - Transfusion
Y1 - 2006///
VL - 46
IS - 9
SP - 1589
EP - 1592
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Srinivasan, K.: HFM-315, Laboratory of Molecular Virology, Division of Emerging and Transmission Transmitted Diseases (DETTD), CBER, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20073082874. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 7439-96-5. Subject Subsets: Public Health
N2 - BACKGROUND: Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS: A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS: Vaccinia viraemia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viraemia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION: The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low.
KW - disease transmission
KW - human diseases
KW - immune response
KW - manganese
KW - smallpox
KW - vaccination
KW - Vaccinia virus
KW - Variola virus
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - immunity reactions
KW - immunological reactions
KW - Mn
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073082874&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=trf
UR - email: kumar.srinivasan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products.
AU - Darnell, M. E. R.
AU - Taylor, D. R.
JO - Transfusion
JF - Transfusion
Y1 - 2006///
VL - 46
IS - 10
SP - 1770
EP - 1777
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Darnell, M. E. R.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20073121782. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 124-07-2. Subject Subsets: Public Health
N2 - BACKGROUND: Severe acute respiratory syndrome coronavirus (SARS-CoV) has been detected in the blood of infected individuals, which may have the potential to contaminate donated blood and plasma-derived products in the event of a future outbreak. Effective methods for inactivating the SARS-CoV in protein solutions are described in this report. STUDY DESIGN AND METHODS: Heat, ultraviolet (UV) irradiation, octanoic acid, and solvent/detergent (S/D) methods were tested individually for their ability to inactivate SARS-CoV in protein solutions appropriately mimicking blood-derived products. Treated samples were tested for inactivation in a tissue culture growth assay. RESULTS: Viral inactivation by heat treatment at 60°C required 15 to 30 minutes to inactivate the SARS-CoV. UVC efficiently inactivated SARS-CoV in 40 minutes, whereas UVA required the addition of psoralen to enhance inactivation of the virus. The presence of bovine serum albumin limited the ability of UVC and UVA to inactivate SARS-CoV and octanoic acid treatment does not reduce the infectivity of SARS-CoV-spiked protein solutions. S/D treatment required 2, 4, and up to 24 hours for Triton X-100, Tween 80, and sodium cholate inactivation, respectively. CONCLUSION: Heat, UVC irradiation, and S/D treatments effectively inactivate SARS-CoV, whereas octanoic acid treatment is insufficient for inactivation of the virus.
KW - blood products
KW - detergents
KW - heating
KW - inactivation
KW - irradiation
KW - octanoic acid
KW - solvents
KW - Coronavirus
KW - Coronaviridae
KW - Nidovirales
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - caprylic acid
KW - SARS coronavirus
KW - Other Control Measures (HH700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073121782&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=trf
UR - email: Deborah.Taylor@FDA.HHS.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Performance of serological assays used to test blood from recent smallpox vaccinees.
AU - Srinivasan, K.
AU - Lee, S.
AU - Daniel, S.
AU - Wood, O.
AU - Akolkar, P.
AU - Hewlett, I.
T2 - Transfusion
JO - Transfusion
JF - Transfusion
Y1 - 2006///
VL - 46
IS - 10
SP - 1847
EP - 1848
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Srinivasan, K.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, CBER, U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20073121787. Publication Type: Correspondence. Language: English. Number of References: 3 ref. Subject Subsets: Public Health
N2 - A study of the potential interference of smallpox vaccination on the results of testing donated blood for infectious disease markers using currently licensed serological assays was conducted. Blood was collected from 75 volunteers who participated in two ongoing clinical trials for smallpox vaccines [USA]. All subjects had received a licensed live vaccinia vaccine. Ethylenediaminetetraacetate- or citrate-anticoagulated venous blood samples were collected on days 0 (before vaccination), 3, 7, 14, 28, and 56 after vaccination and were shippled to a laboratory on wet ice. A total of 356 plasma samples were collected from participants in the two clinical studies. There were 216 samples from 45 individuals from Study A and 140 samples from 30 individuals from Study B. Study A samples were tested for human immunodeficiency virus (HIV) and human T-lymphotrophic virus (HTLV) markers with enyzme immunoassays: Abbott HIV-1 antigen, Abbott HIV-1 and -2, Abbott HTLV-I and -II, Bio-Rad HIV-1, Bio-Rad HIV-2, Bio-Rad HIV-1 and -2, bioMérieux HIV-1, bioMérieux HTLV-I and -II, and the Coulter p24 antigen. Enzyme immunoassays used for testing hepatitis B virus (HBV) markers were Abbott AUSZYME, Abbott CORZYME, Abbott AUSAB, Ortho HBc, Ortho HBsAg, and Bio-Rad HBsAg. Assays for HCV markers were Ortho third-generation HCV and Abbott second-generation HCV. Study B samples were tested for HIV and HTLV markers only, because of insufficient sample. No false-positive reactions for hepatitis B or C markers were observed with postsmallpox vaccination samples from either study. Of 45 prevaccination samples from Study A, 27 were repeatedly reactive for the presence of anti-HBs by the Abbott AUSAB assay. These individuals had been vaccinated recently against hepatitis B. The samples did not react when tested by all other hepatitis assays listed above. Samples from 3 vaccinees gave false-positive results when tested by certain HIV and HTLV assays. Plasma samples collected from two different vaccinees in Study A on days 28 and 56 demonstrated cross-reactivity with the Bio-Rad HIV-1 and -2 antibody assay. Additional testing by Western blot yielded negative results. Also, plasma from one subject in Study B showed reactivity on days 3, 8, 15, and 28 with the Bio-Rad HIV-2 antibody test kit. These samples were tested using the Bio-Rad HIV-1 Western blot and gave negative results. Confirmation of HIV-2 antibodies was not feasible because licensed HIV-2 supplemental tests are currently not available. The results indicate that the likelihood of an acute shortage of transfusable blood and blood products due to false-positive reactions as a result of smallpox vaccination would be low.
KW - analytical methods
KW - assays
KW - enzyme immunoassay
KW - human diseases
KW - immunization
KW - immunological techniques
KW - markers
KW - smallpox
KW - vaccination
KW - Deltaretrovirus
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Human immunodeficiency virus 1
KW - Human T-cell lymphotropic virus type I
KW - Human T-cell lymphotropic virus type II
KW - man
KW - Variola virus
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Human T-cell lymphotropic virus
KW - Deltaretrovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - analytical techniques
KW - HTLV-BLV group
KW - Human immunodeficiency virus type 1
KW - immune sensitization
KW - serological techniques
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073121787&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=trf
UR - email: Indira.Hewlett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002.
AU - Huang, B.
AU - Grant, B. F.
AU - Dawson, D. A.
AU - Stinson, F. S.
AU - Chou, S. P.
AU - Saha, T. D.
AU - Goldstein, R. B.
AU - Smith, S. M.
AU - Ruan, W. J.
AU - Pickering, R. P.
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
Y1 - 2006///
VL - 47
IS - 4
SP - 252
EP - 257
CY - London; UK
PB - W.B. Saunders\Elsevier Science
SN - 0010-440X
AD - Huang, B.: Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA.
N1 - Accession Number: 20063132375. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - The objective of this study was to compare the current prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and mood, anxiety, and personality disorders among whites, blacks, Native Americans, Asians, and Hispanics in a large representative sample of the US population. Striking mental health disparities were observed in the prevalences of psychiatric disorders, especially among Native Americans. Disparities in psychiatric comorbidity differed from those associated with prevalence. Most significantly, the association between alcohol disorders and personality disorders was significantly greater among Asians relative to whites, blacks, and Native Americans, despite lower prevalences of these disorders among Asians. Taken together, the results of this study highlight the need of future studies that help unravel the risk factors underlying the disparities in both prevalence and comorbidity of psychiatric disorders observed among race-ethnic groups in the United States.
KW - alcoholism
KW - anxiety
KW - Asians
KW - blacks
KW - disease prevalence
KW - drug abuse
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - human diseases
KW - mental disorders
KW - mental health
KW - personality
KW - whites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - comorbidity
KW - drug use
KW - ethnic differences
KW - mental illness
KW - psychiatric disorders
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063132375&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCV-4JVTCKT-1&_user=3891418&_handle=V-WA-A-W-AZ-MsSAYZW-UUA-U-AACDDYZVDA-AACCBZDWDA-CCYYACZE-AZ-U&_fmt=full&_coverDate=08%2F31%2F2006&_rdoc=7&_orig=browse&_srch=%23toc%236748%232006%23999529995%23625267!&_cdi=6748&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=f6f3c99bdf2cb24a0a4192edff7bb83b
UR - email: HuangBo@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of polar brevetoxin derivatives isolated from Karenia brevis cultures and natural blooms.
AU - Abraham, A.
AU - Plakas, S. M.
AU - Wang, Z. H.
AU - Jester, E. L. E.
AU - El-Said, K. R.
AU - Granade, H. R.
AU - Henry, M. S.
AU - Blum, P. C.
AU - Pierce, R. H.
AU - Dickey, R. W.
JO - Toxicon
JF - Toxicon
Y1 - 2006///
VL - 48
IS - 1
SP - 104
EP - 115
CY - Oxford; UK
PB - Elsevier
SN - 0041-0101
AD - Abraham, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20073033136. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Weeds
N2 - Several novel brevetoxin derivatives were isolated and identified in Karenia brevis cultures and natural blooms by using solid phase extraction (SPE) and LC/MS(MS) techniques. These analogs were more polar compared with previously described brevetoxins, and were poorly extractable by conventional non-polar solvent (chloroform) partitioning. Brevetoxin analogs were structurally confirmed as hydrolyzed (open A-ring) forms of brevetoxins PbTx-1, PbTx-7, PbTx-2, and PbTx-3, and of oxidized PbTx-1 and PbTx-2. Some of these open A-ring derivatives were in greater abundance than their non-hydrolyzed counterparts. All were in much greater abundance in bloom water filtrate compared with cell-rich fractions. Open A-ring compounds were cytotoxic in mouse neuroblastoma (N2a) cell assay. In the K. brevis bloom-exposed Eastern oyster, brevetoxin metabolites with opened A rings were identified (e.g., open-ring cysteine-PbTx conjugates), contributing to their overall toxin burden.
KW - algal cultures
KW - chemical composition
KW - hydrolysis
KW - metabolites
KW - phytotoxins
KW - plant composition
KW - Crassostrea virginica
KW - Crassostrea
KW - Ostreidae
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Dinoflagellida
KW - Sarcomastigophora
KW - Protozoa
KW - Gymnodiniaceae
KW - Gymnodiniales
KW - chemical constituents of plants
KW - Dinophyta
KW - Karenia
KW - Karenia brevis
KW - Myzozoa
KW - Plant Composition (FF040)
KW - Aquatic Biology and Ecology (MM300)
KW - Pollution and Degradation (PP600)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073033136&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00410101
UR - email: ann.abraham@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Allergen sequence databases.
AU - Gendel, S. M.
AU - Jenkins, J. A.
A2 - Gibson, J.
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
Y1 - 2006///
VL - 50
IS - 7
SP - 633
EP - 637
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1613-4125
AD - Gendel, S. M.: Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063155745. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 21 ref. Subject Subsets: Human Nutrition
N2 - A number of specialized databases have been developed to facilitate studies of human allergens. These include molecular databases focused on protein sequences and structures, informational databases focused on clinical, biochemical and epidemiological data related to protein allergens, a database on allergen nomenclature, and other knowledge bases or informational websites that are peripherally-related to research on allergens. Examples of each type of database are listed and described briefly in this review. Database construction and maintenance and their impact on database quality and usefulness are also discussed.
KW - allergens
KW - amino acid sequences
KW - databases
KW - food
KW - internet
KW - reviews
KW - data banks
KW - protein sequences
KW - web sites
KW - Information and Documentation (CC300)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063155745&site=ehost-live&scope=site
UR - HTTP://www.wiley.com
UR - email: sgendel@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy and food safety considerations of poultry competitive exclusion products.
AU - Wagner, R. D.
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
Y1 - 2006///
VL - 50
IS - 11
SP - 1061
EP - 1071
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1613-4125
AD - Wagner, R. D.: Microbiology Division, National Center for Toxicological Research, HFT-250, 3900 NCTR Road, Jefferson, AR 72079-9501, USA.
N1 - Accession Number: 20073001541. Publication Type: Journal Article. Language: English. Number of References: 88 ref. Subject Subsets: Animal Nutrition; Human Nutrition; Poultry
N2 - Competitive exclusion (CE) products are anaerobic cultures of bacteria that are applied to poultry hatchlings to establish a protective enteric microbiota that excludes intestinal colonization by human food-borne pathogens. For safety of the poultry flock and human consumers, the identities of bacteria in CE products need to be known. A CE product is a culture of intestinal contents from adult chickens. It may be microbiologically defined by analysis of bacteria isolated from the culture, but many bacteria are hard to reliably isolate, identify, and characterize with conventional techniques. Sequence analysis of 16S ribosomal RNA (rRNA) genes may be more reliable than conventional techniques to identify CE bacteria. Bacteria in CE products may contain antimicrobial drug resistance and virulence mechanisms that could be transferred to the enteric bacteria of the food animal and to the human consumer. Detection methods for specific antimicrobial drug resistance and virulence genes and the integrase genes of conjugative transposons, mostly utilizing PCR technology, are being developed that can be applied to assess these risks in CE bacteria. With improvements in efficacy, bacterial identification, and detection and control of the possible risks of gene transfer, CE product technology can be made a more effective food safety tool.
KW - chicken meat
KW - drug resistance
KW - feed additives
KW - food safety
KW - foodborne diseases
KW - gene transfer
KW - genes
KW - human diseases
KW - intestines
KW - microbial flora
KW - polymerase chain reaction
KW - poultry
KW - poultry products
KW - probiotics
KW - resistance mechanisms
KW - transposable elements
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chickens
KW - DNA insertion elements
KW - domesticated birds
KW - insertion elements
KW - insertion sequences
KW - microflora
KW - mobile genetic elements
KW - mobile sequences
KW - PCR
KW - transposons
KW - Meat Producing Animals (LL120)
KW - Animal Nutrition (Production Responses) (LL520)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Feed Additives (RR130)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073001541&site=ehost-live&scope=site
UR - HTTP://www.wiley.com
UR - email: doug.wagner@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The indirect detection of bleach (sodium hypochlorite) in beverages as evidence of product tampering.
AU - Jackson, D. S.
AU - Crockett, D. F.
AU - Wolnik, K. A.
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
Y1 - 2006///
VL - 51
IS - 4
SP - 827
EP - 831
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0022-1198
AD - Jackson, D. S.: Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20073182251. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 122-39-4, 7681-52-9. Subject Subsets: Human Nutrition
N2 - Bleach (sodium hypochlorite) has been identified as the adulterant in a relatively large number of product tamperings that have been investigated by the Forensic Chemistry Center (FCC) of the U.S. Food and Drug Administration. In this work, household bleach was added to 23 different beverages at each of three levels. The impact of sodium hypochlorite on these beverages over a 13-day study period was evaluated using the following techniques: diphenylamine spot test for oxidizing agents, potassium iodide-starch test paper for oxidizing agents, pH, iodometric titration for quantitating hypochlorite, ion chromatography for chloride and chlorate quantitation, automated headspace sampling with gas chromatography-flame ionization detection (GC-FID) for determination of chloroform, and visual and organoleptic observations. This study has shown that hypochlorite is fragile when added to most common beverages and typically breaks down either partially or completely over time. In cases where a beverage is suspected of being adulterated with bleach but tests for hypochlorite are negative, it is still possible to characterize the product to demonstrate that the results are consistent with the addition of bleach. An adulterated product will give a positive test for oxidizing agents using the diphenylamine spot test. It is likely that the pH of the adulterated product will be higher than a control of that product. Ion chromatographic analysis shows elevated chloride and chlorate as compared with a control. And, chloroform may also be detected by GC-FID especially if the beverage that was adulterated contains citric acid.
KW - adulterants
KW - adulteration
KW - beverages
KW - detection
KW - diphenylamine
KW - gas chromatography
KW - organoleptic traits
KW - pH
KW - quantitative techniques
KW - sodium hypochlorite
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - drinks
KW - headspace analysis
KW - hydrogen ion concentration
KW - organoleptic properties
KW - potential of hydrogen
KW - United States of America
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073182251&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/full/10.1111/j.1556-4029.2006.00160.x
UR - email: david.jackson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Internal transcribed spacer dimorphism and diversity in Dientamoeba fragilis.
AU - Windsor, J. J.
AU - Macfarlane, L.
AU - Clark, C. G.
JO - Journal of Eukaryotic Microbiology
JF - Journal of Eukaryotic Microbiology
Y1 - 2006///
VL - 53
IS - 3
SP - 188
EP - 192
CY - Boston; USA
PB - Blackwell Publishing
SN - 1066-5234
AD - Windsor, J. J.: National Public Health Service for Wales Aberystwyth, Bronglais Hospital, Aberystwyth, Ceredigion, SY23 1ER, Wales, UK.
N1 - Accession Number: 20073121792. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology
N2 - The internal transcribed spacer (ITS) region of the ribosomal RNA operon is frequently used for detecting sequence variation among closely related species as it is usually homogeneous within strains but evolves more rapidly than ribosomal RNA coding regions. We have studied this region in both genotypes of the human intestinal parasite Dientamoeba fragilis. In contrast to most organisms, we have identified extensive variation between copies of the sequence within the same strain. The ITS occurs in 2 major forms in each genotype but additional heterogeneity is also present within each form. The significance of this finding is unclear, but the only precedent for such variation is in the Apicomplexa, which have multiple dispersed ribosomal RNA operons in contrast to the tandem arrays found in most other eukaryotes.
KW - genotypes
KW - molecular biology
KW - molecular genetics
KW - operons
KW - phylogenetics
KW - ribosomal RNA
KW - Dientamoeba fragilis
KW - Dientamoeba
KW - Endamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - rRNA
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073121792&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jeu
UR - email: graham.clark@lshtm.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An isotopically labeled internal standard liquid chromatography-tandem mass spectrometry method for determination of ephedrine alkaloids and synephrine in dietary supplements.
AU - Gay, M. L.
AU - Niemann, R. A.
AU - Musser, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 2
SP - 285
EP - 291
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Gay, M. L.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063023054. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 299-42-3, 50-98-6, 134-72-5.
N2 - We report a simplified analytical procedure for determination of ephedrine alkaloids and synephrine in dietary supplements. Cleanup by simple filtration, when combined with tandem mass spectrometry (MS/MS) detection, provided results comparable to our published method with solid phase extraction (SPE) cleanup and single-stage MS detection with in-source fragmentation. We also compared three mass spectrometric experimental configurations: electrospray (ESI) and atmospheric pressure chemical ionization (APCI) with MS/MS and APCI-MS with fragmentation provided by increasing cone voltage. Because these methods used one isotopically labeled internal standard to determine several different analytes, quantitation errors may arise from susceptibility to ionization suppression caused by the matrix. We therefore compared the results obtained by ESI and APCI ionization.
KW - analytical methods
KW - ephedrine
KW - food supplements
KW - isotope dilution
KW - liquid chromatography
KW - mass spectrometry
KW - techniques
KW - analytical techniques
KW - synephrine
KW - Food Composition and Quality (QQ500)
KW - Food Chemistry (QQ600) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063023054&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: mgay@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ion chromatographic determination of perchlorate in foods by on-line enrichment and suppressed conductivity detection.
AU - Niemann, R. A.
AU - Krynitsky, A. J.
AU - Nortrup, D. A.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 4
SP - 1137
EP - 1143
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Niemann, R. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063060632. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Horticultural Science; Human Nutrition; Postharvest Research; Biofuels
N2 - Systemic uptake of perchlorate anion, a rocket fuel component and potential thyroid function disruptor, by leafy vegetables and other crops grown in contaminated waters is a public health concern. A column-switching anion-exchange chromatographic method with suppressed conductivity detection, described in this paper, achieved a 3-6 µg/kg method limit of quantitation in analysis of the wet weight edible portion of cantaloupe, carrots, lettuce, and spinach samples with field-incurred perchlorate. A test portion was blended with dilute nitric acid, and the extract was filtered under vacuum. A portion of the measured filtrate was acidified to pH ~2 by addition of cation-exchange resin, 4 mL was passed through a graphitized carbon cleanup column, and an aliquot of a collected fraction was pushed through a short precolumn for anion extraction, enrichment, and injection onto the analytical column. Statistical comparison with determination by tandem mass spectrometry-ion chromatography analysis of untreated filtrate revealed that the difference between means was not significant at the 95% confidence level (P value ≥0.12) for crops tested. In addition, the method was applied to cooked vegetables processed as baby food.
KW - analytical methods
KW - carrots
KW - chromatography
KW - determination
KW - food contamination
KW - fruits
KW - leafy vegetables
KW - lettuces
KW - melons
KW - perchlorates
KW - spinach
KW - toxic substances
KW - vegetables
KW - Cucumis melo
KW - Daucus carota
KW - Lactuca sativa
KW - Spinacia oleracea
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Daucus
KW - Apiaceae
KW - Apiales
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - analytical techniques
KW - Araliales
KW - food contaminants
KW - green vegetables
KW - ion chromatography
KW - poisons
KW - vegetable crops
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063060632&site=ehost-live&scope=site
UR - email: richard.niemann@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum).
AU - Jhoo, J. W.
AU - Freeman, J. P.
AU - Heinze, T. M.
AU - Moody, J. D.
AU - Schnackenberg, L. K.
AU - Beger, R. D.
AU - Dragull, K.
AU - Tang, C. S.
AU - Ang, C. Y. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 8
SP - 3157
EP - 3162
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Jhoo, J. W.: National Center for Toxicological Research, U.S. Food and Drug Administration, HFT-230, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063096831. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants; Horticultural Science; Public Health
N2 - Kava (Piper methysticum), a perennial shrub native to the South Pacific islands, has been used to relieve anxiety. Recently, several cases of severe hepatotoxicity have been reported from the consumption of dietary supplements containing kava. It is unclear whether the kava constituents, kavalactones, are responsible for the associated hepatotoxicity. To investigate the key components responsible for the liver toxicity, bioassay-guided fractionation was carried out in this study. Kava roots, leaves, and stem peelings were extracted with methanol, and the resulting residues were subjected to partition with a different polarity of solvents (hexane, ethyl acetate, n-butanol, and water) for evaluation of their cytotoxicity on HepG2 cells based on the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and lactate dehydrogenase and aspartate aminotransferase enzyme leakage assays. Organic solvent fractions displayed a much stronger cytotoxicity than water fractions for all parts of kava. The hexane fraction of the root exhibited stronger cytotoxic effects than fractions of root extracted with other solvents or extracts from the other parts of kava. Further investigations using bioassay-directed isolation and analysis of the hexane fraction indicated that the compound responsible for the cytotoxicity was flavokavain B. The identity of the compound was confirmed by 1H and 13C NMR and MS techniques.
KW - cell lines
KW - cytotoxicity
KW - food supplements
KW - lactones
KW - leaves
KW - liver
KW - liver cells
KW - medicinal plants
KW - roots
KW - stems
KW - toxicity
KW - toxicology
KW - man
KW - Piper methysticum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Piper
KW - Piperaceae
KW - Piperales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - drug plants
KW - flavokavain B
KW - hepatocytes
KW - kavalactones
KW - medicinal herbs
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063096831&site=ehost-live&scope=site
UR - email: jjhoo@kangwon.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of multiclass methods for drug residues in eggs: hydrophilic solid-phase extraction cleanup and liquid chromatography/tandem mass spectrometry analysis of tetracycline, fluoroquinolone, sulfonamide, and β-lactam residues.
AU - Heller, D. N.
AU - Nochetto, C. B.
AU - Rummel, N. G.
AU - Thomas, M. H.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 15
SP - 5267
EP - 5278
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Heller, D. N.: Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20063155794. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 60-54-8, 64-75-5. Subject Subsets: Poultry; Veterinary Science; Veterinary Science
N2 - A method was developed for detection of a variety of polar drug residues in eggs via liquid chromatography/tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). A total of twenty-nine target analytes from four drug classes - sulfonamides, tetracyclines, fluoroquinolones, and β-lactams - were extracted from eggs using a hydrophilic-lipophilic balance polymer solid-phase extraction (SPE) cartridge. The extraction technique was developed for use at a target concentration of 100 ng/mL (ppb), and it was applied to eggs containing incurred residues from dosed laying hens. The ESI source was tuned using a single, generic set of tuning parameters, and analytes were separated with a phenyl-bonded silica cartridge column using an LC gradient. In a related study, residues of β-lactam drugs were not found by LC/MS/MS in eggs from hens dosed orally with β-lactam drugs. LC/MS/MS performance was evaluated on two generations of ion trap mass spectrometers, and key operational parameters were identified for each instrument. The ion trap acquisition methods could be set up for screening (a single product ion) or confirmation (multiple product ions). The lower limit of detection for screening purposes was 10-50 ppb (sulfonamides), 10-20 ppb (fluoroquinolones), and 10-50 ppb (tetracyclines), depending on the drug, instrument, and acquisition method. Development of this method demonstrates the feasibility of generic SPE, LC, and MS conditions for multiclass LC/MS residue screening.
KW - analytical methods
KW - beta-lactam antibiotics
KW - detection
KW - drug residues
KW - eggs
KW - extraction
KW - fluoroquinolones
KW - hens
KW - liquid chromatography
KW - mass spectrometry
KW - methodology
KW - poultry
KW - sulfonamides
KW - tetracycline
KW - fowls
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - achromycin
KW - analytical techniques
KW - chickens
KW - domesticated birds
KW - methods
KW - solid-phase extraction
KW - sulphonamides
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063155794&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: david.heller@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of conjugated linoleic acid (CLA) isomers on oxygen diffusion-concentration products in liposomes and phospholipid solutions.
AU - Yin, J. J.
AU - Kramer, J. K. G.
AU - Yurawecz, M. P.
AU - Eynard, A. R.
AU - Mossoba, M. M.
AU - Yu, L. L.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 19
SP - 7287
EP - 7293
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Yin, J. J.: Instrumentation and Biophysics Branch, CFSAN, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063199983. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 60-33-3, 7782-44-7, 121250-47-3, 1839-11-8, 2540-56-9, 2420-56-6, 544-71-8. Subject Subsets: Human Nutrition; Soyabeans
N2 - Conjugated linoleic acids (CLAs) are a group of octadecadienoic acids (18:2) that are naturally present in food products and may have beneficial health effects. Liposomes and ethanol solutions were prepared by mixing synthetic phosphatidylcholines (PCs) with c9,t11-CLA, t10,c12-CLA, and linoleic acid (LA) in the sn-2 position into natural PCs from soybean, egg yolk, rat brain, and rat heart at 5 mol %. The oxygen diffusion-concentration products were measured using electron spin resonance spin-label oximetry methods. Individual synthetic PCs, the phospholipid matrix, and the tested lipid systems all exhibited influence on oxygen diffusion-concentration products during lipid peroxidation. Incorporating 5 mol % PC(c9,t11-CLA) into soy and egg yolk PC increased oxygen consumption in liposome suspensions while it was decreased in rat heart and brain PCs. On the other hand, PC(t10,c12-CLA) increased oxygen consumption in mixtures with egg yolk and rat heart PC but decreased it in soybean and rat brain PC. By comparison, PC(LA) decreased oxygen consumption in every case. In ethanol solutions, all of the synthetic PCs suppressed the capacity to generate peroxide radicals in the order of LA > c9,t11-CLA > t10,c12-CLA. In addition, PCs containing individual CLA isomers and LA differed in their capacities to react with and quench DPPH radicals in both ethanol solution and liposome, suggesting differences between CLA isomers and LA in DPPH radical-fatty acid interactions. Incorporation of CLA isomers and LA into dimyristyl-PC reduced the phase transition temperature from 23.6 to 23.1 and 23.3°C, respectively. The results of this study provide evidence that the behavior of CLA isomers differs in the microenvironment of membranes possibly due to structural differences that affect the permeability of membranes to oxygen and lipid peroxidation.
KW - chemical composition
KW - conjugated linoleic acid
KW - functional foods
KW - linoleic acid
KW - lipid peroxidation
KW - lipids
KW - liposomes
KW - oxygen
KW - phosphatidylcholines
KW - phospholipids
KW - lecithins
KW - lipins
KW - Other Produce (QQ070)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063199983&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: jyin@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermal inactivation of ricin using infant formula as a food matrix.
AU - Jackson, L. S.
AU - Tolleson, W. H.
AU - Chirtel, S. J.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 19
SP - 7300
EP - 7304
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Jackson, L. S.: National Center for Food Safety & Technology, Food and Drug Administration, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063199946. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9009-86-3. Subject Subsets: Dairy Science; Soyabeans
N2 - Ricin is a potent protein toxin found in the seeds of the castor bean plant, Ricinus communis. Ricin specifically and irreversibly inactivates ribosomes, promoting cell death by inhibiting protein synthesis. It is composed of a ribosome-inactivating enzyme (A-chain) linked to a lectin (B-chain) by a single disulfide bond. Several reports indicate that ricin can be detoxified by thermal treatment; however, the conditions required for inactivation are not well characterized. In addition, little information exists on the thermal stability of ricin added to foods. The objective of this work was to determine the effects of heat treatments on the detection and toxicity of ricin added to milk- and soy-based infant formulas. Reconstituted infant formula powders containing 100 µg of ricin/mL were heated at 60-90°C for up to 5 h. The heat-treated formulas were analyzed by ELISA to determine levels of ricin. The residual cytotoxicity of ricin-containing infant formula after heat treatments was determined using RAW264.7 mouse macrophage cells. The ELISA and the cytotoxicity assay indicated that ricin detection and toxicity decreased with increasing heating times and temperatures. Minimal losses in detection and toxicity were found for ricin heated at 60°C for 2 h. The half-lives of ricin cytoxic activity in a milk-based infant formula at 60, 70, 75, 80, 85, and 90°C were >100, 9.8±0.5, 5.8±0.9, 5.1±0.7, 3.1±0.4, and 1.8±0.2 min, respectively; the comparable values for a soy-based infant formula were >100, 16±1.6, 8.7±1.2, 6.9±1.1, 3.0±0.4, and 2.0±0.3 min. ELISA detection was a good indicator of the cytotoxicity of heat-treated ricin. The results indicate that ricin is a relatively heat stable protein and may remain toxic under some food processing conditions.
KW - cytotoxicity
KW - food contamination
KW - heat
KW - heat treatment
KW - infant formulae
KW - ricin
KW - temperature
KW - food contaminants
KW - heat processing
KW - infant formula
KW - infant formulas
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Chemistry (QQ600) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063199946&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: Lauren.Jackson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HPLC-UV method for nicotine, strychnine, and aconitine in dairy products.
AU - Jablonski, J. E.
AU - Schlesser, J. E.
AU - Mariappagoudar, P.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 20
SP - 7460
EP - 7465
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Jablonski, J. E.: U.S. Food and Drug Administration, CFSAN, 6502 South Archer, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063205663. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 54-11-5, 57-24-9. Subject Subsets: Dairy Science
N2 - The toxic nitrogen alkaloids nicotine, strychnine, and aconitine were quantitated in whole milk, skim milk, and cream using solid-phase extraction cleanup and HPLC-UV with dual wavelength detection. Samples were extracted in McIlvaine's buffer with EDTA and then partitioned with aqueous acetonitrile and hexane. The aqueous phase was concentrated and passed through an OASIS HLB column. The column was eluted with methylene chloride/ammonium hydroxide, 1 mL/1 µL, v/v. The eluent was acidified with hydrochloric acid and evaporated. The sample was diluted for HPLC with acetonitrile/phosphate buffer pH 7.4. Chromatography was performed on an Xterra RP-18 column using a gradient of acetonitrile and ammonium bicarbonate buffer at pH 9.8. Nicotine and strychnine were monitored at 260 nm; aconitine was monitored at 232 nm. Calibration curves were generated from external standards in the range 0.2-10 µg/mL using 1/x weighting. Mean recoveries in whole milk spiked between 0.1 and 10 ppm were the following: nicotine 89.2%, strychnine 75.7%, and aconitine 85.1%. Mean recoveries in skim milk spiked between 0.1 and 10 ppm were the following: nicotine 72.1%, strychnine 78.2%, and aconitine 82.9%. Mean recoveries in cream spiked between 0.2 and 20 ppm were the following: nicotine 87.9%, strychnine 76.9%, and aconitine 82.0%. Relative standard deviations of recovery were less than 20% in each case.
KW - alkaloids
KW - analytical methods
KW - cream
KW - food safety
KW - HPLC
KW - milk
KW - milk products
KW - nicotine
KW - skim milk
KW - strychnine
KW - aconitine
KW - analytical techniques
KW - dairy products
KW - high performance liquid chromatography
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063205663&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: joseph.jablonski@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Confirmation of peanut protein using peptide markers in dark chocolate using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
AU - Shefcheck, K. J.
AU - Callahan, J. H.
AU - Musser, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2006///
VL - 54
IS - 21
SP - 7953
EP - 7959
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Shefcheck, K. J.: U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063216351. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition
N2 - Detection of peptides from the peanut allergen Ara h 1 by liquid chromatography-mass spectrometry (LC-MS) was used to identify and estimate total peanut protein levels in dark chocolate. A comparison of enzymatic digestion subsequent to and following extraction of Ara h 1 from the food matrix revealed better limits of detection (LOD) for the pre-extraction digestion (20 ppm) than for the postextraction digestion (50 ppm). Evaluation of LC-MS instruments and scan modes showed the LOD could be further reduced to 10 ppm via a triple-quadrupole and multiple-reaction monitoring. Improvements in extraction techniques combined with an increase in the amount of chocolate extracted (1 g) improved the LOD to 2 ppm of peanut protein. This method provides an unambiguous means of confirming the presence of the peanut protein in foods using peptide markers from a major allergen, Ara h 1, and can easily be modified to detect other food allergens.
KW - allergens
KW - biochemical markers
KW - chocolate
KW - food allergies
KW - groundnut protein
KW - groundnuts
KW - liquid chromatography
KW - mass spectrometry
KW - methodology
KW - peptides
KW - Arachis hypogaea
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - biomarkers
KW - food hypersensitivity
KW - methods
KW - peanut protein
KW - peanuts
KW - Crop Produce (QQ050)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063216351&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: kshefche@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health hazard evaluation of police officers and firefighters after Hurricane Katrina - New Orleans, Louisiana, October 17-28 and November 30-December 5, 2005.
AU - Bernard, B. P.
AU - Driscoll, R. J.
AU - Kitt, M.
AU - West, C. A.
AU - Tak, S. W.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 16
SP - 456
EP - 458
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Bernard, B. P.: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, USA.
N1 - Accession Number: 20063091746. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report summarizes the results of the health hazard evaluation of police officers (17-28 October 2005) and fire fighters (30 November-5 December 2005) after the hurricane Katrina (29 August 2005) in New Orleans, Louisiana, USA. Based on the results, upper respiratory and skin symptoms were the most common physical symptoms reported by police officers and fire fighters, while lacerations and sprain were the most common injuries. Approximately one-third of the respondents reported symptoms of depression, posttraumatic stress disorder, or both. Results indicate the need to incorporate the safety and health of emergency responders into existing disaster preparedness plans, and to provide periodic responder training and education in tasks unique to disaster situations. Clinical follow-up of the physical and psychological health of emergency responders should be conducted to better understand, monitor, and treat their health conditions.
KW - depression
KW - fire fighters
KW - human diseases
KW - hurricanes
KW - mental disorders
KW - mental health
KW - natural disasters
KW - occupational hazards
KW - occupational health
KW - respiratory diseases
KW - skin
KW - skin diseases
KW - trauma
KW - Louisiana
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - West South Central States of USA
KW - dermatoses
KW - dermis
KW - firemen
KW - lung diseases
KW - mental illness
KW - police
KW - post-traumatic stress disorders
KW - psychiatric disorders
KW - traumas
KW - United States of America
KW - Natural Disasters (PP800)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063091746&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Investigation into recalled human tissue for transplantation - United States, 2005-2006.
AU - Malarkey, M.
AU - Solomon, R.
AU - Witten, C.
AU - Bloom, E.
AU - Wells, M.
AU - Braun, M.
AU - Wise, R.
AU - Zinderman, C.
AU - Jernigan, D. B.
AU - Kuehnert, M. J.
AU - Srinivasan, A.
AU - Wang, S.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 20
SP - 564
EP - 566
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Malarkey, M.: Center for Biologics Evaluation and Research, Food and Drug Administration, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20063107893. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Public Health
N2 - This report discusses the investigation carried out by the Food and Drug Administration concerning possible contaminated tissues from human donors who might not have met donor eligibility requirements and who were not screened properly for certain infectious diseases. Records of such tissues, recovered by Biomedical Tissue Services, Ltd, were not consistent with death certificate data obtained from the states where the deaths occurred. The investigation determined that BTS had failed to recover tissues in a manner that would prevent contamination or cross-contamination and failed to control environmental conditions adequately during tissue recovery. Because of these lapses, all tissue products produced from BTS tissues were recalled during September-October 2005.
KW - donors
KW - microbial contamination
KW - tissues
KW - transplantation
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063107893&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adult blood lead epidemiology and surveillance - United States, 2003-2004.
AU - Roscoe, R. J.
AU - Graydon, J. R.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 32
SP - 876
EP - 879
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Roscoe, R. J.: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20063153831. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - This report summarizes the Adult Blood Lead Epidemiology and Surveillance (ABLES) data collected from 37 US states during 2003-04, and compares them with the annual data collected since 1994. The findings indicated that the national prevalence rate of adults with elevated blood lead levels (i.e., ≥25 µg/dl) per 100 000 employed population aged ≥16 years decreased from 8.5 in 2002 to 8.2 in 2003 and 7.5 in 2004. During 2003-04, 94% of adults with identified lead exposure sources were exposed via occupational sources. Projections using the 1994-2004 ABLES data trends indicated that the national prevalence rate of adults with elevated blood levels would be approximately 5.7 per 100 000 employed adults in 2010. It is suggested that increased preventive measures, particularly in work environments, are necessary to achieve the 2010 objective of reducing this rate to zero.
KW - adults
KW - blood
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - lead
KW - lead poisoning
KW - occupational hazards
KW - occupational health
KW - surveillance
KW - toxicity
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063153831&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Advanced cases of coal workers' pneumoconiosis - two counties, Virginia, 2006.
AU - Antao, V. C.
AU - Petsonk, E. L.
AU - Attfield, M. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 33
SP - 909
EP - 913
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Antao, V. C.: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20063177480. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - This report describes 11 cases of advanced coal workers' pneumoconiosis (CWP), including progressive massive fibrosis (PMF), identified in southwestern Virginia, USA during early 2006. Among these patients, the mean age was 51 years (aged 39-62 years), the mean tenure in underground coal mines was 31 years (range, 17-43 years), and the mean number of years working at the coal face was 29 years (range, 17-33 years). PMF is a disabling and potentially fatal form of CWP. The continuing occurrence of advanced forms of CWP emphasizes the importance of comprehensive measures to control coal mine dust effectively and to reduce the potential for inhalation exposures in coal mining.
KW - adults
KW - coal
KW - coal workers
KW - dust
KW - exposure
KW - human diseases
KW - mining
KW - occupational hazards
KW - occupational health
KW - pneumoconioses
KW - USA
KW - Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - pneumoconiosis
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063177480&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Update: Guillain-Barré Syndrome among recipients of Menactra® meningococcal conjugate vaccine - United States, June 2005-September 2006.
AU - Woo, E. J.
AU - Ball, R.
AU - Braun, M.
AU - Clark, T.
AU - Messonnier, N. R.
AU - Wharton, M.
AU - Vellozzi, C.
AU - Campbell, S.
AU - Weintraub, E.
AU - Davis, R.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 41
SP - 1120
EP - 1124
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Woo, E. J.: Center for Biologics Evaluation and Research, Food and Drug Admin, Rockville, Maryland, USA.
N1 - Accession Number: 20073197451. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - This article describes the clinical characteristics of 9 patients who developed Guillain-Barré syndrome (GBS) after receiving the meningococcal conjugate vaccine, Menactra. These cases were notified to the Vaccine Adverse Event Reporting System (VAERS) in USA between March and September 2006. This report also provides a preliminary analysis of data from VAERS and the Vaccine Safety Datalink since Menactra became available in USA in March 2005, and includes all 17 cases of GBS reported since June 2005. Although these data suggest a small increase in the GBS risk after Menactra vaccination, the inherent limitations of VAERS and the uncertainty regarding background incidence rates for GBS require that these findings be viewed with caution. Because of the risk for meningococcal disease and the associated morbidity and mortality, it is still recommended that routine Menactra vaccination be given to adolescents, college freshmen living in dormitories, and other high-risk populations.
KW - adolescents
KW - adults
KW - adverse effects
KW - bacterial diseases
KW - brain
KW - children
KW - clinical aspects
KW - conjugate vaccines
KW - disease incidence
KW - disease prevention
KW - epidemiology
KW - Guillain-Barre syndrome
KW - human diseases
KW - immunization
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Neisseria meningitidis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cerebrum
KW - clinical picture
KW - immune sensitization
KW - Meningococcus
KW - teenagers
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073197451&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diagnosed diabetes among American Indians and Alaska natives aged <35 years - United States, 1994-2004.
AU - Acton, K. J.
AU - Burrows, N. R.
AU - Wang, J.
AU - Geiss, L. S.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
IS - 44
SP - 1201
EP - 1203
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Acton, K. J.: Div of Diabetes Treatment and Prevention, Indian Health Service, India.
N1 - Accession Number: 20063234535. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Public Health
N2 - This article reports the prevalence of diagnosed diabetes among American indians (AI) and Alaska natives (AN) aged <35 years in USA, which was based on the data collected by the Indian Health Service during 1994-2004. During the study period, the age-adjusted prevalence of diagnosed diabetes increased from 8.5 to 17.1% per 1000 persons among young AI/AN adults, increasing by an average of 7.7% per year. The prevalence of diabetes was higher among females than males in all age groups. Because young adults with diabetes have more years of disease and greater risk for costly and disabling complications early in life, diabetes prevention programmes targeting younger age groups have become increasingly important in AI/AN communities.
KW - adults
KW - Alaska Natives
KW - American indians
KW - diabetes
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - ethnic groups
KW - human diseases
KW - young adults
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063234535&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Engineering and public health at CDC.
AU - Earnest, G. S.
AU - Reed, L. D.
AU - Conover, D.
AU - Estill, C.
AU - Gjessing, C.
AU - Gressel, M.
AU - Hall, R.
AU - Hudock, S.
AU - Hudson, H.
AU - Kardous, C.
AU - Sheehy, J.
AU - Topmiller, J.
AU - Trout, D.
AU - Woebkenberg, M.
AU - Amendola, A.
AU - Hsiao, H.
AU - Keane, P.
AU - Weissman, D.
AU - Finfinger, G.
AU - Tadolini, S.
AU - Thimons, E.
AU - Cullen, E.
AU - Jenkins, M.
AU - McKibbin, R.
AU - Conway, G.
AU - Husberg, B. (et al)
T3 - Special Issue: 60 years of Public Health Science at CDC.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
SP - 10
EP - 13
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Earnest, G. S.: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073039206. Publication Type: Journal Article. Note: Special Issue: 60 years of Public Health Science at CDC. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - This article highlights the contributions of engineering to the Centers for Disease Control's health protection goals: study of air contaminants, lung function, mining health effects, safety, physical agents (noise, heat and radiation), ergonomics and the environment.
KW - air pollutants
KW - air pollution
KW - engineering
KW - environmental factors
KW - ergonomics
KW - health protection
KW - heat
KW - lung function
KW - mining
KW - noise
KW - occupational hazards
KW - occupational health
KW - public health
KW - radiation
KW - safety
KW - atmospheric pollution
KW - human engineering
KW - Pollution and Degradation (PP600)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073039206&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
UR - email: gearnest@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Statistics and public health at CDC.
AU - Sieber, W. K., Jr.
AU - Green, T.
AU - Williamson, G. D.
T3 - Special Issue: 60 years of Public Health Science at CDC.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2006///
VL - 55
SP - 22
EP - 24
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Sieber, W. K., Jr.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073039210. Publication Type: Journal Article. Note: Special Issue: 60 years of Public Health Science at CDC. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - This article highlights the contributions of statistics to the Centers for Disease Control's health protection and research goals.
KW - health promotion
KW - public health
KW - research
KW - statistics
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - studies
KW - Non-food/Non-feed Animal Products (SS100)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073039210&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
UR - email: wsieber@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Characterization of class 1 integron resistance gene cassettes in Salmonella enterica serovars Oslo and Bareily from imported seafood.
AU - Khan, A. A.
AU - Cheng, C. M.
AU - Van, K. T.
AU - West, C. S.
AU - Nawaz, M. S.
AU - Khan, S. A.
T2 - Journal of Antimicrobial Chemotherapy
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2006///
VL - 58
IS - 6
SP - 1308
EP - 1310
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Khan, A. A.: Division of Microbiology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073007798. Publication Type: Correspondence. Language: English. Number of References: 9 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 56-75-7, 8064-90-2, 57-92-1, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - A study was conducted to evaluate the integron-mediated antibiotic resistance in 105 Salmonella strains isolated from seafoods that were imported from 20 countries in the USA, during 2000-05. The strains were identified, serotyped and tested for levels of resistance to commonly used antibiotics. Two Salmonella strains (serovars Bareily and Oslo) were resistant to trimethoprim-sulfamethoxazole, sulfisoxazole, ampicillin, tetracycline and chloramphenicol, and were characterized for class 1 integron. Both strains amplified a 1.24 kb polymerase chain reaction product by using the primers CSL1 and CSR1, suggesting the presence of class 1 integrase (intI1). In addition, both strains were positive for the trimethoprim-sulfamethoxazole resistance gene dfrA1, amplifying a 414 bp amplicon. Both strains also amplified the entire coding region (792 bp) of the streptomycin resistance gene aadA2, but the serovar Bareily strain did not show phenotypic resistance to streptomycin. Sequence analysis of the 1.24 kb clones of both strains revealed the presence of dfrA1, conferring resistance to trimethoprim-sulfamethoxazole, and an open reading frame orfC gene cassette of unknown function. The gene cassette showed 100% identity with the dfrA1 and orfC genes encoding resistance to trimethoprim-sulfamethoxazole and unknown function, respectively. This study indicates that antimicrobial-resistant Salmonella serovars are prevalent in imported seafoods.
KW - ampicillin
KW - antibacterial agents
KW - antibiotics
KW - chloramphenicol
KW - co-trimoxazole
KW - food contamination
KW - genes
KW - imports
KW - microbial contamination
KW - multiple drug resistance
KW - nucleotide sequences
KW - open reading frames
KW - resistance mechanisms
KW - seafoods
KW - serovars
KW - strains
KW - streptomycin
KW - sulfamethoxazole
KW - tetracycline
KW - transposable elements
KW - trimethoprim
KW - USA
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - bacterium
KW - DNA insertion elements
KW - DNA sequences
KW - food contaminants
KW - insertion elements
KW - insertion sequences
KW - integrons
KW - mobile genetic elements
KW - mobile sequences
KW - ORFs
KW - sulfisoxazole
KW - sulphamethoxazole
KW - transposons
KW - United States of America
KW - International Trade (EE600)
KW - Pesticide and Drug Resistance (HH410)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073007798&site=ehost-live&scope=site
UR - http://jac.oxfordjournals.org/
UR - email: Ashraf.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Association between home smoking restrictions and changes in smoking behaviour among employed women.
AU - Shopland, D. R.
AU - Anderson, C. M.
AU - Burns, D. M.
A2 - Greaves, L.
A2 - Vallone, D.
A2 - Velicer, W.
T3 - Special issue: Tobacco control policy and low socioeconomic status women and girls.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2006///
VL - 60
IS - Suppl. II
SP - ii44
EP - ii50
CY - London; UK
PB - BMJ Publishing Group
SN - 0143-005X
AD - Shopland, D. R.: US Public Health Service, Ringgold, Georgia, USA.
N1 - Accession Number: 20063162506. Publication Type: Journal Article. Note: Special issue: Tobacco control policy and low socioeconomic status women and girls. Language: English. Number of References: 46 ref. Subject Subsets: Public Health
N2 - Study objective: Examine trends in home smoking restrictions among employed women not living alone and assess the associations of such restrictions with smoking behaviour. Design: Multivariate logistic regression analysis of major demographic variables and household composition characteristics. Study participants: 128 024 employed female respondents to the Census Bureau's current population survey over the 10 year period 1992 to 2002. Main results: The prevalence of smoke free homes has increased significantly over the past decade. This increase was evident across all demographic and household characteristics examined with the greatest rate of increase seen among smoking households. Nearly 90% of households consisting of all never smoking adult members reported having a smoke free home in 2001-02 compared with 22% of households consisting of all smokers. The extent of smoking restrictions in the home was the most powerful determinant of cessation of all the factors examined in the regression model. Odds of becoming a former smoker (any length) and quit for three months or more were seven to eight times greater among those women reporting their homes were smoke free compared with those whose homes permitted smoking anywhere in the home. Conclusions: Smoke free homes were associated with a highly significant increase in quitting (p<0.0001). However, at this time it is not clear what proportion of the observed effect can be attributed to living in a smoke free home. None the less, the significantly increased probability of quitting correlated with having a smoke free home found in this analysis, are substantially higher than the odds reported in most workplace studies published to date; additional studies are needed to elucidate this relation.
KW - behaviour modification
KW - behavioural changes
KW - employed women
KW - public health
KW - tobacco smoking
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior change
KW - behavior modification
KW - United States of America
KW - working women
KW - Women (UU500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063162506&site=ehost-live&scope=site
UR - http://www.bmjjournals.com
UR - email: reedonald@aol.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Dientamoeba fragilis and Blastocystis hominis using a simple staining method.
AU - Windsor, J. J.
AU - Bamber, A. I.
AU - MacFarlane, L.
JO - British Journal of Biomedical Science
JF - British Journal of Biomedical Science
Y1 - 2006///
VL - 63
IS - 1
SP - 27
EP - 28
CY - Tunbridge Wells; UK
PB - Step Publishing Limited
SN - 0967-4845
AD - Windsor, J. J.: National Public Health Service for Wales, Microbiology Aberystwyth, Bronglais Hospital, Caradoc Road, Aberystwyth, Ceredigion SY23 1ER, Wales, UK.
N1 - Accession Number: 20063204792. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 17372-87-1, 61-73-4. Subject Subsets: Protozoology
N2 - This study investigated the use of a commercial rapid differential staining method for Dientamoeba fragilis and Blastocystis hominis detection. Smears were made from faecal samples in which round refractile bodies were seen on direct saline microscopy. After air drying, the smears were stained using the Diff-3 kit. The smears were fixed in industrial methylated spirit for 10 seconds and then stained with eosine for 2-4 seconds. After a rinse in the wash buffer, the slides were stained with polychrome methylene blue for 3-4 seconds, rinsed with wash buffer and air dried. The results proved comparable with those obtained with Giemsa or Field's stain. D. fragilis and B. hominis were detected using the Diff-3 kit and confirmed using the Robinson's xenic parasite culture. This staining method was also used to confirm Giardia lamblia [G. duodenalis] trophozoites from a clinical sample. It is concluded that the use of a rapid differential stain can be recommended to confirm putative D. fragilis and B. hominis positive specimens when unstructured refractile bodies are seen on direct microscopy.
KW - detection
KW - differential staining
KW - eosine
KW - faeces
KW - methylene blue
KW - microscopy
KW - smears
KW - techniques
KW - trophozoites
KW - Blastocystis hominis
KW - Dientamoeba fragilis
KW - Giardia duodenalis
KW - Blastocystis
KW - Amoebida incertae sedis
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Dientamoeba
KW - Endamoebidae
KW - Giardia
KW - Hexamitidae
KW - Diplomonadida
KW - feces
KW - methylthioninium chloride
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063204792&site=ehost-live&scope=site
UR - http://www.bjbs-online.org/
UR - email: jeff.windsor@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Non-fatal occupational injury among active and passive smokers in small- and medium-scale manufacturing enterprises in Japan.
AU - Nakata, A.
AU - Ikeda, T.
AU - Takahashi, M.
AU - Haratani, T.
AU - Hojou, M.
AU - Fujioka, Y.
AU - Araki, S.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2006///
VL - 63
IS - 9
SP - 2452
EP - 2463
CY - Oxford; UK
PB - Elsevier
SN - 0277-9536
AD - Nakata, A.: National Institute of Occupational Safety and Health, Japan.
N1 - Accession Number: 20063181814. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health
N2 - Active smoking is a risk factor for occupational injury, whereas its association with passive smoking is unknown. To evaluate the contribution of active and passive smoking to non-fatal occupational injury in manufacturing sectors, 2302 randomly selected workers aged 16-83 years working in 244 small- and medium-scale enterprises in Yashio city, Japan, were surveyed by means of a self-administered questionnaire. Smoking history, exposure to passive smoking, and occupational injury were evaluated by self-report. Exposure levels to passive smoking were assessed separately at work and at home as never, occasional, or regular exposure. Overall, 61.4% of men and 22.3% of women were current smokers. Among never smokers, 62.2% of men and 68.6% of women reported exposure to passive smoking either at work or home. Prevalence of occupational injuries was 36.2% for never, 43.3% for former, and 41.2% for current smokers among men and 19.7% for never, 22.2% for former, and 25.2% for current smokers among women. Among never smoking men, odds ratios (ORs) of occupational injury were 2.11 when regularly exposed to passive smoking at work or at home (p=0.025), 2.27 at work (p=0.015), and 3.08 at home (p=0.106), in comparison to never smoking men who were never exposed to passive smoking either at work or at home (referent group). These associations were attenuated to be non-significant, after controlling for potential confounders. Never smoking men with occasional exposure to passive smoking were not significant ORs (1.11-1.19). In contrast, current and former smoking men had significant increases in adjusted ORs (1.57-2.00). In women exposed to smoking there was a non-significant increase in occupational injury. The present study indicates an expected increase in the risk of, occupational injury for current and former smoking men and suggests that exposure to passive smoking is a possible risk factor for never smoking men.
KW - epidemiology
KW - human diseases
KW - men
KW - occupational hazards
KW - occupational health
KW - passive smoking
KW - risk factors
KW - sex
KW - sex differences
KW - tobacco smoking
KW - trauma
KW - women
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - traumas
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063181814&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02779536
UR - email: nakataa-tky@umin.ac.jp\ikedat@ipu.ac.jp\takaham@h.jniosh.go.jp\haratani@h.jniosh.go.jp\hojoh@big.or.jp\yosei@guri-gura.com\araki@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chromium picolinate intake and risk of type 2 diabetes: an evidence-based review by the United States Food and Drug Administration.
AU - Trumbo, P. R.
AU - Ellwood, K. C.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2006///
VL - 64
IS - 8
SP - 357
EP - 363
CY - Washington; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Trumbo, P. R.: Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20063185739. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Human Nutrition
N2 - The labelling of both health claims that meet significant scientific agreement (SSA) and qualified health claims on conventional foods and dietary supplements requires pre-market approval by the US Food and Drug Administration (FDA). Approval by the FDA involves, in part, a thorough review of the scientific evidence to support an SSA or a qualified health claim. This article discusses FDA's evidence-based review of the scientific evidence on the role of chromium picolinate supplements in reducing the risk of type 2 diabetes. Based on this evidence-based review, FDA issued a letter of enforcement discretion for one qualified health claim on chromium picolinate and risk of insulin resistance, a surrogate endpoint for type 2 diabetes. The agency concluded that the relationship between chromium picolinate intake and insulin resistance is highly uncertain.
KW - functional foods
KW - insulin resistance
KW - reviews
KW - risk
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chromium picolinate
KW - type 2 diabetes mellitus
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Other Produce (QQ070)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063185739&site=ehost-live&scope=site
UR - email: Paula.Trumbo@FDA.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Validation of a PCR-based method for the detection of various rendered materials in feedstuffs using a forensic DNA extraction kit.
AU - Myers, M. J.
AU - Yancy, H. F.
AU - Araneta, M.
AU - Armour, J.
AU - Derr, J.
AU - Hoostelaere, L. A. D.
AU - Farmer, D.
AU - Jackson, F.
AU - Kiessling, W. M.
AU - Koch, H.
AU - Lin, H. H.
AU - Liu, Y.
AU - Mowlds, G.
AU - Pinero, D.
AU - Riter, K. L.
AU - Sedwick, J.
AU - Shen, Y. L.
AU - Wetherington, J.
AU - Younkins, R.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 1
SP - 205
EP - 210
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Myers, M. J.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708, USA.
N1 - Accession Number: 20063023943. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9007-49-2. Subject Subsets: Animal Nutrition; Human Nutrition; Pig Science
N2 - A method trial was initiated to validate the use of a commercial DNA forensic kit to extract DNA from animal feed as part of a PCR-based method. Four different PCR primer pairs (one bovine pair, one porcine pair, one ovine primer pair, and one multispecies pair) were also evaluated. Each laboratory was required to analyze a total of 120 dairy feed samples either not fortified (control, true negative) or fortified with bovine meat and bone meal, porcine meat and bone meal (PMBM), or lamb meal. Feeds were fortified with the animal meals at a concentration of 0.1% (wt/wt). Ten laboratories participated in this trial, and each laboratory was required to evaluate two different primer pairs, i.e., each PCR primer pair was evaluated by five different laboratories. The method was considered to be validated for a given animal source when three or more laboratories achieved at least 97% accuracy (29 correct of 30 samples for 96.7% accuracy, rounded up to 97%) in detecting the fortified samples for that source. Using this criterion, the method was validated for the bovine primer because three laboratories met the criterion, with an average accuracy of 98.9%. The average false-positive rate was 3.0% in these laboratories. A fourth laboratory was 80% accurate in identifying the samples fortified with bovine meat and bone meal. A fifth laboratory was not able to consistently extract the DNA from the feed samples and did not achieve the criterion for accuracy for either the bovine or multispecies PCR primers. For the porcine primers, the method was validated, with four laboratories meeting the criterion for accuracy with an average accuracy of 99.2%. The fifth laboratory had a 93.3% accuracy outcome for the porcine primer. Collectively, these five laboratories had a 1.3% false-positive rate for the porcine primer. No laboratory was able to meet the criterion for accuracy with the ovine primers, most likely because of problems with the synthesis of the primer pair; none of the positive control DNA samples could be detected with the ovine primers. The multispecies primer pair was validated in three laboratories for use with bovine meat and bone meal and lamb meal but not with PMBM. The three laboratories had an average accuracy of 98.9% for bovine meat and bone meal, 97.8% for lamb meal, and 63.3% for PMBM. When examined on an individual laboratory basis, one of these four laboratories could not identify a single feed sample containing PMBM by using the multispecies primer, whereas the other laboratory identified only one PMBM-fortified sample, suggesting that the limit of detection for PMBM with this primer pair is around 0.1% (wt/wt). The results of this study demonstrated that the DNA forensic kit can be used to extract DNA from animal feed, which can then be used for PCR analysis to detect animal-derived protein present in the feed sample.
KW - bone meal
KW - chemical composition
KW - contamination
KW - DNA
KW - feed of animal origin
KW - feeds
KW - meat and bone meal
KW - methodology
KW - polymerase chain reaction
KW - deoxyribonucleic acid
KW - feeding stuffs
KW - methods
KW - PCR
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Feed Composition and Quality (RR300)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063023943&site=ehost-live&scope=site
UR - email: mmyers@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiplex real-time PCR detection of heat-labile and heat-stable toxin genes in enterotoxigenic Escherichia coli.
AU - Grant, M. A.
AU - Hu, J. X.
AU - Jinneman, K. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 2
SP - 412
EP - 416
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Grant, M. A.: Pacific Regional Laboratory Northwest, U.S. Food and Drug Administration, 22201 23rd Drive S.E., Bothell, WA 98021, USA.
N1 - Accession Number: 20063049399. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition
N2 - A multiplex real-time PCR method was developed for detection of heat-labile and heat-stable toxin genes in enterotoxigenic Escherichia coli. Approximately 10 CFU per reaction mixture could be detected in rinsates from produce samples. Several foods representative of varieties previously shown to have caused enterotoxigenic E. coli outbreaks were spiked and enriched for 4 or 6 h. Both heat-labile and heat-stable toxin genes could be detected in the foods tested, with the exception of hot sauce, with threshold cycle values ranging from 25.2 to 41.1. A procedure using membrane filtration which would allow enumeration of the enterotoxigenic E. coli population in a food sample in less than 28 h by real-time PCR analysis of colonies picked from media highly selective for E. coli was also developed.
KW - analytical methods
KW - bacterial diseases
KW - enterotoxins
KW - food contamination
KW - genes
KW - molecular biology
KW - molecular genetics
KW - polymerase chain reaction
KW - techniques
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - biochemical genetics
KW - E. coli
KW - food contaminants
KW - PCR
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063049399&site=ehost-live&scope=site
UR - email: mike.grant@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of antimicrobial-resistant Salmonella isolated from imported foods.
AU - Zhao, S.
AU - McDermott, P. F.
AU - Friedman, S.
AU - Qaiyumi, S.
AU - Abbott, J.
AU - Kiessling, C.
AU - Ayers, S.
AU - Singh, R.
AU - Hubert, S.
AU - Sofos, J.
AU - White, D. G.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 3
SP - 500
EP - 507
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20063072425. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 69-52-3, 69-53-4, 7177-48-2, 56-75-7, 9007-49-2, 1403-66-3, 1405-41-0, 8063-07-8, 389-08-2, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Human Nutrition
N2 - Two-hundred eight Salmonella isolates recovered from over 5,000 imported foods entering the United States in 2001 were tested for antimicrobial susceptibilities and further characterized for quinolone resistance mechanisms, integron carriage, and genetic relatedness. Salmonella Weltevreden (20%), Salmonella Newport (6%), Salmonella Lexington (5%), and Salmonella Thompson (4%) were the four most common serotypes recovered. Twenty-three (11%) isolates were resistant to at least one antimicrobial, and seven (3.4%) to three or more antimicrobials. Resistance was most often observed to tetracycline (9%), followed by sulfamethoxazole (5%), streptomycin (4%), nalidixic acid (3%), and trimethoprim/sulfamethoxazole (2%). One Salmonella Schwarzengrund isolate recovered from squid imported from Taiwan exhibited resistance to eight antimicrobials, including ampicillin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, sulfamethoxazole, tetracycline, and trimethoprim/sulfamethoxazole. Six isolates (Salmonella Bareilly, Salmonella Derby, Salmonella Ohio and three Salmonella Schwarzengrund) contained class 1 integrons, which carried several resistance genes including dhfrI/dhfrXII, aadA, pse-1, and sat1, conferring resistance to trimethoprim/sulfamethoxazole, streptomycin, ampicillin, and streptothricin, respectively. Five of six nalidixic acid-resistant isolates possessed DNA point mutations at either Ser83 or Asp87 in DNA gyrase. One ciprofloxacin-resistant isolate possessed double mutations in DNA gyrase at positions Ser83 and Asp87 as well as a single mutation at Ser80 in parC. The top three serotypes identified, Salmonella Weltevreden (n=41), Salmonella Newport (n=13), and Salmonella Lexington (n=11), were further characterized for genetic relatedness by pulsed-field gel electrophoresis. Fifty-five distinct pulsed-field gel electrophoresis patterns were observed among the 65 isolates, indicating extensive genetic diversity among these Salmonella serotypes contaminating imported foods.
KW - ampicillin
KW - antibacterial agents
KW - chloramphenicol
KW - DNA
KW - drug resistance
KW - food contamination
KW - genes
KW - gentamicin
KW - kanamycin
KW - microbial contamination
KW - mutations
KW - nalidixic acid
KW - quinolones
KW - resistance mechanisms
KW - sulfamethoxazole
KW - tetracycline
KW - trimethoprim
KW - USA
KW - Streptomyces
KW - Streptomycetaceae
KW - Streptomycineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - achromycin
KW - bacterium
KW - deoxyribonucleic acid
KW - food contaminants
KW - Salmonella bareilly
KW - Salmonella derby
KW - Salmonella lexington
KW - Salmonella newport
KW - Salmonella ohio
KW - Salmonella schwarzengrund
KW - Salmonella thompson
KW - Salmonella weltevreden
KW - streptothricin
KW - sulphamethoxazole
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063072425&site=ehost-live&scope=site
UR - email: dwhite@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Optimization of ferrioxamine E concentration as effective supplementation for selective isolation of Salmonella Enteritidis in egg white.
AU - Thammasuvimol, G.
AU - Seo, K. H.
AU - Song, K. Y.
AU - Holt, P. S.
AU - Brackett, R. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 3
SP - 634
EP - 638
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Thammasuvimol, G.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063072443. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 9006-50-2. Subject Subsets: Human Nutrition
N2 - Utilization of ferrioxamine E (FE) as a sole source of iron distinguishes Salmonella from a number of related species, including Escherichia coli. FE is not able to serve as a source of iron for E. coli or the Proteus-Providencia-Morganella group. This confers a selective advantage on Salmonella Enteritidis in egg white supplemented with FE. The optimum concentration of FE that promoted a selective advantage for Salmonella in egg white was determined. Four supplementation concentrations were evaluated (25, 50, 200, and 500 µg/ml) in egg white artificially inoculated with proportionally mixed cultures of a rifampin-resistant strain of Salmonella Enteritidis (0.1 ml of 102 CFU/ml) and E. coli K-12 (0.1 ml of 101 through 108 CFU/ml). After a 24-h incubation at 37°C, Salmonella and E. coli populations were enumerated. At higher concentrations of FE (>50 µg/ml), both Salmonella and E. coli were able to use the iron supplement (1 to 8.5 log CFU/ml and 1.8 to 8 log CFU/ml, respectively); however, lower FE concentrations (≤50 µg/ml) exclusively promoted Salmonella growth. Salmonella was unrecoverable without supplementation. This study indicates that optimum levels of FE supplementation in egg can improve the selective detection for Salmonella Enteritidis among other competitive organisms.
KW - egg albumen
KW - Escherichia coli
KW - Providencia
KW - Salmonella
KW - Salmonella enteritidis
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Proteus (Bacteria)
KW - Salmonella
KW - bacterium
KW - E. coli
KW - egg white
KW - ferrioxamine E
KW - Morganella
KW - Proteus
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063072443&site=ehost-live&scope=site
UR - email: kseo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and enumeration of Salmonella Enteritidis in homemade ice cream associated with an outbreak: comparison of conventional and real-time PCR methods.
AU - Seo, K. H.
AU - Valentin-Bon, I. E.
AU - Brackett, R. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 3
SP - 639
EP - 643
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Seo, K. H.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063072444. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Salmonellosis caused by Salmonella Enteritidis (SE) is a significant cause of foodborne illnesses in the United States. Consumption of undercooked eggs and egg-containing products has been the primary risk factor for the disease. The importance of the bacterial enumeration technique has been enormously stressed because of the quantitative risk analysis of SE in shell eggs. Traditional enumeration methods mainly depend on slow and tedious most-probable-number (MPN) methods. Therefore, specific, sensitive, and rapid methods for SE quantitation are needed to collect sufficient data for risk assessment and food safety policy development. We previously developed a real-time quantitative PCR assay for the direct detection and enumeration of SE and, in this study, applied it to naturally contaminated ice cream samples with and without enrichment. The detection limit of the real-time PCR assay was determined with artificially inoculated ice cream. When applied to the direct detection and quantification of SE in ice cream, the real-time PCR assay was as sensitive as the conventional plate count method in frequency of detection. However, populations of SE derived from real-time quantitative PCR were approximately 1 log higher than provided by MPN and CFU values obtained by conventional culture methods. The detection and enumeration of SE in naturally contaminated ice cream can be completed in 3 h by this real-time PCR method, whereas the cultural enrichment method requires 5 to 7 days. A commercial immunoassay for the specific detection of SE was also included in the study. The real-time PCR assay proved to be a valuable tool that may be useful to the food industry in monitoring its processes to improve product quality and safety.
KW - detection
KW - food contamination
KW - ice cream
KW - microbial contamination
KW - polymerase chain reaction
KW - salmonellosis
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - PCR
KW - Salmonella infections
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063072444&site=ehost-live&scope=site
UR - email: kseo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Three-year surveillance program examining the prevalence of Campylobacter and Salmonella in whole retail raw chicken.
AU - Meldrum, R. J.
AU - Smith, R. M. M.
AU - Wilson, I. G.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 4
SP - 928
EP - 931
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20063088555. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Poultry
N2 - A 36-month study of Campylobacter and Salmonella in retail raw whole chicken was carried out to measure baseline rates at the retail level, establish seasonality, and observe changes in rates over time. In total, 2,228 samples were taken between November 2001 and December 2004. The Campylobacter rate was unchanged over the 3 years of the study, but the Salmonella rates declined significantly between 2001 and 2004. There was also some seasonality in Campylobacter rates in fresh samples. The overall conclusion from the study was that the Salmonella rate in raw chicken available to consumers in Wales fell significantly between 2001 and 2004, while the Campylobacter rate remained unchanged and is still by far the greater problem.
KW - chicken meat
KW - food contamination
KW - microbial contamination
KW - poultry
KW - seasonality
KW - surveillance
KW - UK
KW - Wales
KW - Campylobacter
KW - fowls
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - United Kingdom
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063088555&site=ehost-live&scope=site
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of a five-strain cocktail of Escherichia coli O157:H7 during the 60-day aging period of Cheddar cheese made from unpasteurized milk.
AU - Schlesser, J. E.
AU - Gerdes, R.
AU - Ravishankar, S.
AU - Madsen, K.
AU - Mowbray, J.
AU - Teo, A. Y. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 5
SP - 990
EP - 998
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Schlesser, J. E.: National Center for Food Safety and Technology, Food and Drug Administration, Moffett Campus, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063110054. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Dairy Science
N2 - The U.S. Food and Drug Administration Standard of Identity for Cheddar cheeses requires pasteurization of the milk, or as an alternative treatment, a minimum 60-day aging at ≥2°C for cheeses made from unpasteurized milk, to reduce the number of viable pathogens that may be present to an acceptable risk. The objective of this study was to investigate the adequacy of the 60-day minimum aging to reduce the numbers of viable pathogens and evaluate milk subpasteurization heat treatment as a process to improve the safety of Cheddar cheeses made from unpasteurized milk. Cheddar cheese was made from unpasteurized milk inoculated with 101 to 105 CFU/ml of a five-strain cocktail of acid-tolerant Escherichia coli O157:H7. Samples were collected during the cheese manufacturing process. After pressing, the cheese blocks were packaged into plastic bags, vacuum sealed, and aged at 7°C. After 1 week, the cheese blocks were cut into smaller-size uniform pieces and then vacuum sealed in clear plastic pouches. Samples were plated and enumerated for E. coli O157:H7. Populations of E. coli O157:H7 increased during the cheese-making operations. Population of E. coli O157:H7 in cheese aged for 60 and 120 days at 7°C decreased less than 1 and 2 log, respectively. These studies confirm previous reports that show 60-day aging is inadequate to eliminate E. coli O157:H7 during cheese ripening. Subpasteurization heat-treatment runs were conducted at 148°F (64.4°C) for 17.5 s on milk inoculated with E. coli O157:H7 at 105 CFU/ml. These heat-treatment runs resulted in a 5-log E. coli O157:H7 reduction.
KW - Cheddar cheese
KW - cheese ripening
KW - cheesemaking
KW - food contamination
KW - pasteurization
KW - USA
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia coli
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - cheese making
KW - E. coli
KW - food contaminants
KW - pasteurizing
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063110054&site=ehost-live&scope=site
UR - email: Jschless@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of magnetic resonance for detection of bacterial contamination in low-acid, shelf-stable packaged soymilk.
AU - Pascall, M. A.
AU - Ravishankar, S.
AU - Ghiron, K.
AU - Lee, B. T.
AU - Johannessen, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 7
SP - 1668
EP - 1674
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Pascall, M. A.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063151851. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Soyabeans; Dairy Science; Human Nutrition
N2 - This study evaluated magnetic resonance (MR) as a nondestructive method for detection of bacterial contamination in shelf-stable soymilk and cheese sauce. To accomplish this, individual 355-ml polymeric trays filled with soymilk and inoculated with Bacillus stearothermophilus and Bacillus subtilis (103 CFU) were incubated for up to 28 h at 55°C and 62 h at 37°C, respectively. MR relaxation times (T2) of these samples were then correlated with the bacterial growth as well as viscosity and pH changes caused by the bacteria in the packaged soymilk. In addition, this study investigated the ability of MR to differentiate between regularly processed cheese sauce and cheese sauce that was modified with a-amylase as a spoilage simulation. Results showed increased MR T2 relaxation times after the bacterial populations reached 108 CFU/ml (after 18 h) and 107 CFU/ml (after 44 h) for B. stearothermophilus and B. subtilis, respectively. B. subtilis had an undetectable influence on viscosity but a profound influence on pH. B. stearothermophilus, in comparison, significantly lowered the pH and increased the viscosity of the soymilk. MR was able to distinguish between regularly processed 85-g pouches of cheese sauce and other pouches with sauce that were modified with 0.5 ml of 1% α-amylase solution. These results showed that MR has the potential to be used for nondestructive detection of physical changes in soymilk and cheese sauce induced by bacterial growth and enzymatic activities, respectively.
KW - analytical methods
KW - cheeses
KW - detection
KW - food contamination
KW - magnetic resonance imaging
KW - microbial contamination
KW - pH
KW - soya milk
KW - viscosity
KW - Bacillus subtilis
KW - Geobacillus stearothermophilus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Geobacillus
KW - analytical techniques
KW - Bacillus stearothermophilus
KW - bacterium
KW - food contaminants
KW - hydrogen ion concentration
KW - potential of hydrogen
KW - soy milk
KW - soyabean milk
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063151851&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: pascall.1@osu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of an alkaline phosphatase-labeled oligonucleotide probe for the detection and enumeration of the thermostable-related hemolysin (trh) gene of Vibrio parahaemolyticus.
AU - Nordstrom, J. L.
AU - Rangdale, R.
AU - Vickery, M. C. L.
AU - Phillips, A. M. B.
AU - Murray, S. L.
AU - Wagley, S.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006///
VL - 69
IS - 11
SP - 2770
EP - 2772
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Nordstrom, J. L.: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville Drive, P.O. Box 158, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20063238472. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 9007-49-2, 7732-18-5. Subject Subsets: Human Nutrition
N2 - Reliable methods are needed to detect total and pathogenic Vibrio parahaemolyticus. One marker of V. parahaemolyticus virulence is the thermostable-related hemolysin. We developed an alkaline phosphatase-labeled DNA probe method for the specific detection and enumeration of trh-positive V. parahaemolyticus by colony hybridization. The probe was tested against a panel of 200 bacterial strains and determined to be specific for trh-positive V. parahaemolyticus. Additionally, the trh alkaline phosphatase probe colony hybridization was successfully used to detect and enumerate trh-positive V. parahaemolyticus in seafood and water samples collected from the United States and the United Kingdom.
KW - DNA
KW - DNA probes
KW - food contamination
KW - genes
KW - haemolysins
KW - microbial contamination
KW - molecular genetics
KW - mussels
KW - oysters
KW - seafoods
KW - techniques
KW - water
KW - UK
KW - USA
KW - crabs
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - APEC countries
KW - North America
KW - America
KW - bacterium
KW - biochemical genetics
KW - Britain
KW - deoxyribonucleic acid
KW - food contaminants
KW - hemolysins
KW - United Kingdom
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063238472&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: jessica.nordstrom@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in Sprague-Dawley rats.
AU - Hwang MyungSil
AU - Park MiSun
AU - Moon JiYoung
AU - Lee JiSun
AU - Yum YoungNa
AU - Yoon EungKyung
AU - Lee HyoMin
AU - Nam KiTaek
AU - Lee ByungMu
AU - Kim SeungHee
AU - Yang KiHwa
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2006///
VL - 69
IS - 23/24
SP - 2157
EP - 2165
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Hwang MyungSil: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20063231191. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - The subchronic toxicity of Aristolochiae fructus (dried fruits of Aristolochia contorta) containing aristolochic acids (AAs), a natural component in the Aristolochiaceae family, was investigated. The A. fructus was daily administered by gavage to male and female rats for 90 days at 21.35, 213.5, and 2135 mg/kg (equivalent to 0.05, 0.5, and 5 mg/kg as AAs, respectively). During the test period, clinical signs, mortality, body weights, food and water consumption, haematology, serum biochemistry, organ weights, and histopathology were examined. There were significant decreases in body weight gain in the high-dose group receiving both the aqueous extract of A. fructus and AAs. Decreases in food consumption were noted beginning at 50 days and did not recover in the high-dose group of aqueous extract of A. fructus and AAs. Irrespective of dose, water consumption was not affected. There was no mortality or adverse clinical signs, haematology, or serum biochemistry in the treatment groups versus the control. Nephrotoxicity and hyperplasia of epithelial cells in the forestomach were observed in rats receiving the highest dose of aqueous extract of A. fructus and at doses of ≥0.5 mg kg-1 day-1 AAs. For both genders, the no-observed-adverse-effect level (NOAEL) for A. fructus based on this subchronic study in rats was considered to be 21.3 mg kg-1 day-1.
KW - animal models
KW - fruits
KW - medicinal plants
KW - plant extracts
KW - toxicity
KW - traditional Chinese medicines
KW - Aristolochia
KW - rats
KW - Aristolochiaceae
KW - Aristolochiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Aristolochia
KW - Aristolochia contorta
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063231191&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: bmlee@skku.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acid resistance of twelve strains of Enterobacter sakazakii, and the impact of habituating the cells to an acidic environment.
AU - Edelson-Mammel, S.
AU - Porteous, M. K.
AU - Buchanan, R. L.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2006///
VL - 71
IS - 6
SP - M201
EP - M207
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0022-1147
AD - Edelson-Mammel, S.: DHHS Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20063190926. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Soyabeans; Dairy Science
N2 - The association of powdered infant formula with cases of severe Enterobacter sakazakii infections in immunocompromised and premature neonates has led to a need to learn about the basic behavior of this emerging pathogen in food systems and the environment. The current study examines the microorganism's stationary-phase acid resistance using 12 strains that had been previously used to characterize its thermal resistance. Acid resistance was determined by initially culturing the isolates for 18 h in brain heart infusion broth (BHI) at 36°C, transferring the cells to tryptic soy broth (TSB) adjusted to pH 3.0 and 3.5, and determining E. sakazakii survival over the course of 5 h incubation at 36°C. At pH 3.5, 10 of the 12 strains showed less than a 1 log cycle decline over the 5-h incubation period, with the most acid sensitive strain showing an approximate 3.5 log cycle decline. At pH 3.0, the decline over the 5-h incubation period ranged from 4.9 to >6.3 log cycles; however, substantial diversity was evident when the 1-h/pH 3.0 results were compared. The effect of habituating the cells to a moderately acidic environment was determined by growing the strains in TSB with 0% (nonacidogenic) and 1% glucose (acidogenic), transferring the cells to acidified (pH 3.0) BHI, and determining E. sakazakii survival over the course of 5 h of incubation at 36°C. While there was diversity observed among the strains, in general the stationary-phase acid resistances of several of the strains were enhanced, at least transitorily, by growth in the acidogenic medium. No apparent correlation between the stationary-phase relative acid resistances of the strains based on the 1-h/pH 3.0 acid inactivation values and the previously reported thermal D-values was observed.
KW - bacterial diseases
KW - food contamination
KW - heat resistance
KW - infant formulae
KW - pH
KW - Enterobacter sakazakii
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - hydrogen ion concentration
KW - infant formula
KW - infant formulas
KW - potential of hydrogen
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063190926&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/JFDS
UR - email: robert.buchanan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of type A, B, E, and F Clostridium botulinum neurotoxins in foods by using an amplified enzyme-linked immunosorbent assay with digoxigenin-labeled antibodies.
AU - Sharma, S. K.
AU - Ferreira, J. L.
AU - Eblen, B. S.
AU - Whiting, R. C.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2006///
VL - 72
IS - 2
SP - 1231
EP - 1238
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Sharma, S. K.: U.S. Food and Drug Administration, Center for Food Safety Applied Nutrition, HFS-302, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063059407. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 1672-46-4. Subject Subsets: Potatoes; Human Nutrition; Horticultural Science; Dairy Science; Aromatic & Medicinal Plants
N2 - An amplified enzyme-linked immunosorbent assay (ELISA) for the detection of Clostridium botulinum complex neurotoxins was evaluated for its ability to detect these toxins in food. The assay was found to be suitable for detecting type A, B, E, and F botulinum neurotoxins in a variety of food matrices representing liquids, solid, and semisolid food. Specific foods included broccoli, orange juice, bottled water, cola soft drinks, vanilla extract, oregano, potato salad, apple juice, meat products, and dairy foods. The detection sensitivity of the test for these botulinum complex serotypes was found to be 60 pg/ml (1.9 50% lethal dose [LD50]) for botulinum neurotoxin type A (BoNT/A), 176 pg/ml (1.58 LD50) for BoNT/B, 163 pg/ml for BoNT/E (4.5 LD50), and 117 pg/ml for BoNT/F (less than 1 LD50) in casein buffer. The test could also readily detect 2 ng/ml of neurotoxins type A, B, E, and F in a variety of food samples. For specificity studies, the assay was also used to test a large panel of type A C. botulinum, a smaller panel of proteolytic and nonproteolytic type B, E, and F neurotoxin-producing Clostridia, and nontoxigenic organisms using an overnight incubation of toxin production medium. The assay appears to be an effective tool for large-scale screening of the food supply in the event of a botulinum neurotoxin contamination event.
KW - antibodies
KW - apple juice
KW - bottled water
KW - broccoli
KW - digoxigenin
KW - ELISA
KW - food contamination
KW - foods
KW - meat products
KW - microbial contamination
KW - milk products
KW - neurotoxins
KW - orange juice
KW - potatoes
KW - salads
KW - serotypes
KW - soft drinks
KW - techniques
KW - Brassica oleracea
KW - Clostridium botulinum
KW - Origanum vulgare
KW - Solanum tuberosum
KW - Vanilla
KW - Brassica
KW - Brassicaceae
KW - Capparidales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Origanum
KW - Lamiaceae
KW - Lamiales
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Orchidaceae
KW - Orchidales
KW - monocotyledons
KW - bacterium
KW - calabrese
KW - Capparales
KW - dairy products
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - marjoram
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063059407&site=ehost-live&scope=site
UR - http://www.asm.org
UR - email: shashi.sharma@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Produce isolates of the Escherichia coli Ont:H52 serotype that carry both Shiga toxin 1 and stable toxin genes.
AU - Monday, S. R.
AU - Keys, C.
AU - Hanson, P.
AU - Shen, Y. L.
AU - Whittam, T. S.
AU - Feng, P.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2006///
VL - 72
IS - 4
SP - 3062
EP - 3065
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Monday, S. R.: Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063087298. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - Produce isolates of the Escherichia coli Ont:H52 serotype carried Shiga toxin 1 and stable toxin genes but only expressed Stx1. These strains had pulsed-field gel electrophoresis profiles that were 90% homologous to clinical Ont:H52 strains that had identical phenotypes and genotypes. All Ont:H52 strains had identical single nucleotide polymorphism profiles that are suggestive of a unique clonal group.
KW - bacterial toxins
KW - food contamination
KW - fruits
KW - genes
KW - genetic polymorphism
KW - microbial contamination
KW - shiga toxin-producing Escherichia coli
KW - vegetables
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - Escherichia coli Ont:H52
KW - food contaminants
KW - STEC
KW - vegetable crops
KW - VTEC
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063087298&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: pfeng@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung - importance of mouse strain.
AU - Calvert, R. J.
AU - Tepper, S.
AU - Kammouni, W.
AU - Anderson, L. M.
AU - Kritchevsky, D.
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2006///
VL - 72
IS - 12
SP - 1749
EP - 1755
CY - New York; USA
PB - Elsevier
SN - 0006-2952
AD - Calvert, R. J.: Division of Research and Applied Technology, Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063235523. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 57-88-5, 11041-12-6, 37220-17-0, 59-67-6. Subject Subsets: Human Nutrition
N2 - Our previous work established that hypocholesterolemic agents altered K-ras intracellular localization in lung. Here, we examined K-ras activity to define further its potential importance in lung carcinogenesis. K-ras activity in lungs from male A/J, Swiss and C57BL/6 mice was examined. For 3 weeks, mice consumed either 2 or 4% cholestyramine (CS), 1% niacin, 5% konjac mannan (KM), or were injected with lovastatin 25 mg/kg three or five times weekly (Lov-3X and Lov-5X). A pair-fed (PF) group was fed the same quantity of diet consumed by the Lov-5X mice to control for lower body weights in Lov-5X mice. After 3 weeks, serum cholesterol was assayed with a commercial kit. Activated K-ras protein from lung was affinity precipitated with a Raf-1 ras binding domain-glutathione-S-transferase fusion protein bound to glutathione-agarose beads, followed by Western blotting, K-ras antibody treatment, and chemiluminescent detection. Only KM reduced serum cholesterol (in two of three mouse strains). In C56BL/6 mice treated with Lov-3X, lung K-ras activity increased 1.8-fold versus control (p=0.009). In normal lung with wild-type K-ras, this would be expected to be associated with maintenance of differentiation. In A/J mice fed 4% CS, K-ras activity increased 2.1-fold (p=0.02), which might be responsible for the reported enhancement of carcinogenesis in carcinogen-treated rats fed CS. KM feeding and PF treatment had no significant effects on K-ras activity. These data are consistent with the concept that K-ras in lung has an oncogenic function when mutated, but may act as a tumor suppressor when wild-type.
KW - animal models
KW - carcinogenesis
KW - cholesterol
KW - colestyramine
KW - konjac mannan
KW - laboratory animals
KW - lungs
KW - nicotinic acid
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cholestyramine
KW - lovastatin
KW - niacin
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063235523&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00062952
UR - email: calvert@mail.ncifcrf.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Classification of some heat-treated liver pastes according to container type, using heavy metals content and manufacturer's data, by principal components analysis and potential curves.
AU - Brito, G.
AU - Andrade, J. M.
AU - Havel, J.
AU - Díaz, C.
AU - García, F. J.
AU - Peña-Méndez, E. M.
JO - Meat Science
JF - Meat Science
Y1 - 2006///
VL - 74
IS - 2
SP - 296
EP - 302
CY - Oxford; UK
PB - Elsevier
SN - 0309-1740
AD - Brito, G.: Department of Health, Canary Islands Public Health Service, Canary Government, 38004-S/C de Tenerife, Tenerife, Spain.
N1 - Accession Number: 20063177309. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 7440-43-9, 7440-47-3, 7440-48-4, 7440-50-8, 7439-89-6, 7439-92-1, 7439-96-5, 7440-02-0, 7440-66-6. Subject Subsets: Human Nutrition; Pig Science
N2 - A total of 115 pork liver pastes were randomly collected in local markets from different brands, countries and containers. The concentrations of nine heavy metals (Cu, Ni, Cd, Fe, Mn, Pb, Cr, Co and Zn), determined by atomic absorption spectrometry, and some qualitative variables described on the labelling constituted the data set. Chemometrics analysis was performed combining principal components analysis (PCA), factor analysis (FA) and typical classification techniques, such as linear discriminant analysis (LDA) and potential curves (PoCu) to classify pork liver pastes. Origin of the sample, manufacturer and effect of manufacturing process were taken into account to verify traceability, which is an important issue in food safety policies.
KW - cadmium
KW - chromium
KW - cobalt
KW - copper
KW - food contamination
KW - food processing
KW - food safety
KW - heat treatment
KW - heavy metals
KW - iron
KW - lead
KW - livers as food
KW - manganese
KW - meat products
KW - nickel
KW - pigmeat
KW - zinc
KW - food contaminants
KW - heat processing
KW - Mn
KW - pork
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063177309&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03091740
UR - email: empena@ull.es
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Routine markerless gene replacement in Bacillus anthracis.
AU - Janes, B. K.
AU - Stibitz, S.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2006///
VL - 74
IS - 3
SP - 1949
EP - 1953
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Janes, B. K.: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063057439. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - An improved genetic tool suitable for routine markerless allelic exchange in Bacillus anthracis has been constructed. Its utility was demonstrated by the introduction of insertions, deletions, and missense mutations on the chromosome and plasmid pXO1 of the Sterne strain of B. anthracis.
KW - genes
KW - methodology
KW - molecular genetics
KW - mutations
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - methods
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063057439&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: stibitz@helix.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of extracellular and intracellular potency of botulinum neurotoxins.
AU - Cai, F.
AU - Adrion, C. B.
AU - Keller, J. E.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2006///
VL - 74
IS - 10
SP - 5617
EP - 5624
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Cai, F.: Laboratory of Bacterial Toxins, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063199544. Publication Type: Journal Article. Language: English. Number of References: 51 ref. Registry Number: 60-00-4, 7440-66-6. Subject Subsets: Public Health
N2 - Levels of botulinum neurotoxin (BoNT) proteolytic activity were compared using a cell-free assay and living neurons to measure extracellular and intracellular enzymatic activity. Within the cell-free reaction model, BoNT serotypes A and E (BoNT/A and BoNT/E, respectively) were reversibly inhibited by chelating Zn2+ with N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN). BoNT/E required relatively long incubation with TPEN to achieve total inhibition, whereas BoNT/A was inhibited immediately upon mixing. When naïve Zn2+-containing BoNTs were applied to cultured neurons, the cellular action of each BoNT was rapidly inhibited by subsequent addition of TPEN, which is membrane permeable. Excess Zn2+ added to the culture medium several hours after poisoning fully restored intracellular toxin activity. Unlike TPEN, EDTA irreversibly inhibited both BoNT/A and -E within the cell-free in vitro reaction. Excess Zn2+ did not reactivate the EDTA-treated toxins. However, application of EDTA-treated BoNT/A or -E to cultured neurons demonstrated normal toxin action in terms of both blocking neurotransmission and SNAP-25 proteolysis. Different concentrations of EDTA produced toxin preparations with incrementally reduced in vitro proteolytic activities, which, when applied to living neurons showed undiminished cellular potency. This suggests that EDTA renders the BoNT proteolytic domain conformationally inactive when tested with the cell-free reaction, but this change is corrected during entry into neurons. The effect of EDTA is unrelated to Zn2+ because TPEN could be applied to living cells before or after poisoning to produce rapid and reversible inhibition of both BoNTs. Therefore, bound Zn2+ is not required for toxin entry into neurons, and removal of Zn2+ from cytosolic BoNTs does not irreversibly alter toxin structure or function. We conclude that EDTA directly alters both BoNTs in a manner that is independent of Zn2+.
KW - EDTA
KW - enzyme activity
KW - neurons
KW - neurotoxins
KW - potency
KW - proteolysis
KW - zinc
KW - edetic acid
KW - ethylenediaminetetraacetic acid
KW - nerve cells
KW - neurones
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063199544&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: james.keller@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection, confirmation, and quantification of staphylococcal enterotoxin B in food matrixes using liquid chromatography-mass spectrometry.
AU - Callahan, J. H.
AU - Shefcheck, K. J.
AU - Williams, T. L.
AU - Musser, S. M.
JO - Analytical Chemistry (Washington)
JF - Analytical Chemistry (Washington)
Y1 - 2006///
VL - 78
IS - 6
SP - 1789
EP - 1800
CY - Washington; USA
PB - American Chemical Society
SN - 0003-2700
AD - Callahan, J. H.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063116286. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Although immunoassay-based methods are sensitive and widely used for measuring protein toxins in food matrixes, there is a need for methods that can directly confirm the molecular identity of the toxin in situations where immunoassay tests yield a positive result. A method has been developed that uses mass spectrometry to identify a protein toxin, staphylococcal enterotoxin B (SEB), in a model food matrix, apple juice. The approach employs ultrafiltration to remove low molecular weight components from the sample, after which the remaining high molecular weight fraction, containing the protein, is digested with trypsin. The tryptic fragments are separated from residual biopolymers and analyzed by liquid chromatography-electrospray mass spectrometry. The background is still sufficiently complex that tandem mass spectrometry (MS/MS) is used to confirm the identity of target peptides. Limits of detection are 80 ng of SEB for MS and 100 ng for full scan MS/MS, using a tryptic fragment as the analytical target. Lower detection limits can be obtained using selected ion monitoring and multiple reaction monitoring. The presence of SEB can be confirmed at concentrations as low as 5 parts-per-billion by increasing the size of the sample to 10 mL. The method is applicable to the detection of SEB in other water-soluble food matrixes.
KW - analytical methods
KW - apple juice
KW - bacterial toxins
KW - enterotoxins
KW - food contamination
KW - fruit juices
KW - liquid chromatography
KW - mass spectrometry
KW - microbial contamination
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063116286&site=ehost-live&scope=site
UR - http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2006/78/i06/abs/ac051292v.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Co-circulation of genotype IA and new variant IB hepatitis A virus in outbreaks of acute hepatitis in Hungary - 2003/2004.
AU - Reuter, G.
AU - Juhász, Á.
AU - Kosztolányi, L.
AU - Lefler, É.
AU - Fekete, Z.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2006///
VL - 78
IS - 11
SP - 1392
EP - 1397
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Reuter, G.: Regional Laboratory of Virology, Department of Epidemiology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság út 7., H-7623 Pécs, Hungary.
N1 - Accession Number: 20063211157. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Hepatitis A virus (HAV) is one of the most important causes of acute infectious hepatitis worldwide. In Hungary, the reported number of HAV infections has been decreasing in the last four decades, nevertheless, still, each year 500-800 new cases and multiple outbreaks occur, particularly in the northeast region of Hungary. In Hungary, serology is used routinely to establish the diagnosis of HAV infection without genetic analysis of HAV strains for molecular epidemiology. In this study, serum samples collected from symptomatic patients were tested by enzyme-immunoassay (anti-HAV-IgM ELISA) to establish the cause of three acute hepatitis A outbreaks (outbreak 1 - from low prevalence region in Southwest Hungary in 2003 and outbreaks 2 and 3 from the endemic region in Northeast Hungary in 2004). Outbreak strains were characterized by reverse transcription-polymerase chain reaction (RT-PCR) amplification of a 360 bp viral VP1/2A region, amplicon sequencing and phylogenetic analysis. Four, seven, and three sera from outbreaks 1, 2, and 3, respectively, were investigated by RT-PCR for HAV genome and HAV RNA was detected in 4 (100%), 4 (57%), and 2 (67%) samples. All strains belonged to genotype I HAV. Outbreak 1 was caused by the new variant subtype IB and outbreaks 2 and 3 caused by genetically identical subtype IA strains. The Hungarian IA and IB hepatitis A viruses had the highest nucleotide identity, 98.4% and 99.0%, to IT-SCH-00 and IT-MAR-02 strains, respectively, detected in year 2000 and 2002 in Italy. Endemic subtype IA and probably imported new variant subtype IB HAV viruses was detected in outbreaks of hepatitis in Hungary that are closely related genetically to HAV strains in Italy.
KW - disease prevalence
KW - genotypes
KW - hepatitis A
KW - molecular epidemiology
KW - molecular genetics
KW - outbreaks
KW - phylogenetics
KW - Hungary
KW - Hepatitis A virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063211157&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: reuterg@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High and persistent excretion of hepatitis A virus in immunocompetent patients.
AU - Tjon, G. M. S.
AU - Coutinho, R. A.
AU - Hoek, A. van den
AU - Esman, S.
AU - Wijkmans, C. J.
AU - Hoebe, C. J. P. A.
AU - Wolters, B.
AU - Swaan, C.
AU - Geskus, R. B.
AU - Dukers, N.
AU - Bruisten, S. M.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2006///
VL - 78
IS - 11
SP - 1398
EP - 1405
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Tjon, G. M. S.: Department of Infectious Diseases, Public Health Service of Amsterdam, 1000 CE, Achtergracht 100, 1018 WT Amsterdam, Netherlands.
N1 - Accession Number: 20063211158. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - The duration and level of virus excretion in blood and faeces of patients with hepatitis A virus (HAV) infection were studied in relation to levels of alanine aminotransferase (ALT), disease severity and HAV genotype. Clinical data, blood and faeces were collected from 27 patients with acute hepatitis A (median age: 33 years) for a maximum of 26 weeks. Single blood donations from 55 other patients with acute HAV (median age: 32 years) were also used. Virus loads were quantified by competitive nested RT-PCR. HAV was excreted in faeces for a median period of 81 days after disease onset, with 50% of patients still excreting high levels at Day 36 (2×106-2×108 copies/ml faeces suspension). Viraemia was detected, but not quantifiable, for a median period of 42 days. In the first 10 days of illness, higher ALT levels were correlated with higher viraemia levels. Comparison of patients infected with genotype 1a with those infected with type 1b did not differ significantly in terms of the duration of HAV excretion or jaundice. In conclusion, faecal excretion of HAV is at a high titre in the first month, perhaps making patients infectious for a longer period than assumed currently. Blood banks should be aware that viraemia may be present for more than 1 month, and genotype did not affect the duration of virus excretion or jaundice.
KW - adults
KW - blood
KW - clinical aspects
KW - disease course
KW - genotypes
KW - hepatitis A
KW - human diseases
KW - human faeces
KW - liver
KW - liver diseases
KW - viraemia
KW - viral load
KW - Netherlands
KW - Hepatitis A virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - clinical picture
KW - disease progression
KW - human feces
KW - viremia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063211158&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: sbruisten@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of FDA licensed HIV assays using plasma from Cameroonian blood donors.
AU - Lee, S.
AU - Hu, J. J.
AU - Tang, S. X.
AU - Wood, O.
AU - Francis, K.
AU - Machuca, A.
AU - Rios, M.
AU - Daniel, S.
AU - Vockley, C.
AU - Awazi, B.
AU - Zekeng, L.
AU - Hewlett, I.
A2 - Schochetman, G.
A2 - Kuhns, M. C.
T3 - Special Issue: HIV variants and hepatitis B surface antigen mutants: diagnostic challenges for immunoassays.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2006///
VL - 78
IS - Suppl.1
SP - S22
EP - S23
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Lee, S.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bldg. 29B, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063151986. Publication Type: Journal Article. Note: Special Issue: HIV variants and hepatitis B surface antigen mutants: diagnostic challenges for immunoassays. Language: English. Number of References: 6 ref. Subject Subsets: Public Health
N2 - Several diagnostic assays for the detection of HIV infection have been approved and licensed by the FDA for blood donor screening. However, the performance of these assays is unknown when testing genetically divergent blood specimens. To evaluate the performance of these assays with diverse HIV strains, we chose to study specimens collected from blood donors in Cameroon where genetic diversity and recombinant variants are prevalent. In this study, we tested 240 human plasma specimens collected from two blood centers in Cameroon. These samples were screened initially in Cameroon for antibody to HIV using a rapid assay. We also performed sequencing to determine subtype. Our evaluation has demonstrated that HIV infection in most HIV plasma samples could be detected by most of the US FDA licensed diagnostic assays. With the exception of a few specimens, HIV-1 p24 antigen was not detected in any of the samples. In addition, some nucleic acid tests (NAT) assays were not able to detect a few serologic reactive samples and all new variants including some CRF02_AG variants.
KW - analytical methods
KW - assays
KW - blood donors
KW - blood plasma
KW - blood products
KW - HIV infections
KW - Human immunodeficiency viruses
KW - screening
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - analytical techniques
KW - human immunodeficiency virus infections
KW - plasma (blood)
KW - screening tests
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063151986&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: hewlett@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infections by hepatitis B surface antigen gene mutants in Europe and North America.
AU - Tabor, E.
A2 - Schochetman, G.
A2 - Kuhns, M. C.
T3 - Special Issue: HIV variants and hepatitis B surface antigen mutants: diagnostic challenges for immunoassays.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2006///
VL - 78
IS - Suppl.1
SP - S43
EP - S47
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Tabor, E.: Office of Blood Research and Review, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063151990. Publication Type: Journal Article. Note: Special Issue: HIV variants and hepatitis B surface antigen mutants: diagnostic challenges for immunoassays. Language: English. Number of References: 24 ref. Subject Subsets: Soyabeans; Public Health
N2 - Hepatitis B virus (HBV) mutants have usually been studied in patients in Asia because of the wider use of HBV immunization there and the resultant emergence of viral mutants. Nevertheless, HBV surface antigen (S) gene mutants also are found in Europe and North America. In Europe and North America, HBV with mutations in the portion of the S gene coding the "a" determinant of the hepatitis B surface antigen (HBsAg) have been documented in small numbers of infants born to HBV-infected mothers following post-natal HBV vaccine and hepatitis B immune globulin (HBIG) prophylaxis and in many liver transplant recipients who develop HBV re-infection despite HBIG prophylaxis. In some cases, these mutations have included a glycine to arginine substitution at position 145 (G145R), which results in a conformational change and different reactivity to monoclonal antibody reagents than that of the wild-type virus. Mutations in the a determinant (but not G145R) also have been reported in European patients with chronic HBV infection who have not received HBV vaccine or HBIG. However, it appears that such mutations are only responsible for a small proportion of "occult" or "silent" HBV infections, which are characterized by the presence of HBV DNA in serum in the absence of detectable HBsAg. However, some of these mutant forms of HBV in cases of occult HBV may theoretically escape detection and could present a risk to blood safety.
KW - genes
KW - hepatitis B
KW - human diseases
KW - infants
KW - mothers
KW - mutants
KW - mutations
KW - nucleotide sequences
KW - strains
KW - surface antigens
KW - Europe
KW - North America
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - DNA sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063151990&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: edward.tabor@quintiles.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human immunodeficiency virus (HIV) vaccine trials: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies.
AU - Khurana, S.
AU - Needham, J.
AU - Mathieson, B.
AU - Rodriguez-Chavez, I. R.
AU - Catanzaro, A. T.
AU - Bailer, R. T.
AU - Kim, J.
AU - Polonis, V.
AU - Cooper, D. A.
AU - Guerin, J.
AU - Peterson, M. L.
AU - Gurwith, M.
AU - Nga Nguyen
AU - Graham, B. S.
AU - Golding, H.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006///
VL - 80
IS - 5
SP - 2092
EP - 2099
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Khurana, S.: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063238643. Publication Type: Journal Article. Corporate Author: USA, HIV Vaccine Trial Network Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - All current human immunodeficiency virus (HIV) vaccine candidates contain multiple viral components and elicit antibodies that react positively in licensed HIV diagnostic tests, which contain similar viral products. Thus, vaccine trial participants could be falsely diagnosed as infected with HIV. Additionally, uninfected, seropositive vaccinees may encounter long-term social and economic harms. Moreover, this also interferes with early detection of true HIV infections during preventive HIV vaccine trials. An HIV-seropositive test result among uninfected vaccine trial participants is a major public health concern for volunteers who want to participate in future HIV vaccine trials. Based on the increased number of HIV vaccines being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Using a whole-HIV-genome phage display library, we identified conserved sequences in Env-gp41 and Gag-p6 which are recognized soon after infection, do not contain protective epitopes, and are not part of most current HIV vaccines. We established a new HIV serodetection assay based on these peptides. To date, this assay, termed HIV-SELECTEST, demonstrates >99% specificity and sensitivity. Importantly, in testing of plasma samples from multiple HIV vaccine trials, uninfected trial participants scored negative, while all intercurrent infections were detected within 1 to 3 months of HIV infection. The new HIV-SELECTEST is a simple but robust diagnostic tool for easy implementation in HIV vaccine trials and blood banks worldwide.
KW - accuracy
KW - antibodies
KW - assays
KW - diagnosis
KW - diagnostic techniques
KW - epitopes
KW - human diseases
KW - Human immunodeficiency viruses
KW - vaccine development
KW - vaccines
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenic determinants
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063238643&site=ehost-live&scope=site
UR - http://jvi.asm.org/cgi/reprint/80/5/2092
UR - email: goldingh@cber.FDA.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects.
AU - Shin JaeHo
AU - Moon HyunJu
AU - Kim TaeSung
AU - Kang IlHyun
AU - Ki HoYeon
AU - Choi KwangSik
AU - Han SoonYoung
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2006///
VL - 80
IS - 9
SP - 547
EP - 554
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 0340-5761
AD - Shin JaeHo: Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20063186011. Publication Type: Journal Article. Language: English. Registry Number: 50471-44-8, 15262-86-9, 315-37-7, 57-85-2, 5721-91-5, 58-22-0, 1255-69-8. Subject Subsets: Plant Pathology
N2 - We performed a 28-day repeated-dose toxicity study of vinclozolin, a widely used fungicide, based on the draft protocol of the "Enhanced OECD Test Guideline 407" (Enhanced TG407) to investigate whether vinclozolin has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with vinclozolin daily by oral gavage at dose rates of 0, 3.125, 12.5, 50 and 200 mg/kg/day for at least 28 days. The vinclozolin-treated male rats showed a reduction of epididymis and accessory sex organ weights and an alteration of hormonal patterns. A slight prolongation of the oestrous cycle and changes in the estrogen/testosterone ratio and luteinizing hormone level were observed in vinclozolin-treated female rats. Thyroxin concentrations were decreased and thyroid-stimulating hormone concentrations were increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of vinclozolin could be detected by the parameters examined in the present study based on the OECD protocol, suggesting the Enhanced TG407 protocol should be a suitable screening test for the detection of endocrine-mediated effects of chemicals.
KW - animal models
KW - fungicides
KW - hormonal control
KW - nontarget effects
KW - oestrogens
KW - reproductive organs
KW - sex hormones
KW - testosterone
KW - thyroid gland
KW - toxicity
KW - vinclozolin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - endocrine control
KW - estrogens
KW - fungistats
KW - hormonal regulation
KW - thyroid
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063186011&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/40707u4214463245/?p=6e51b323b0c043f4b0be8d0d3ccedefd&pi=0
UR - email: jaehoshin@hanmir.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sexual violence inside prisons: rates of victimization.
AU - Wolff, N.
AU - Blitz, C. L.
AU - Shi, J.
AU - Bachman, R.
AU - Siegel, J. A.
JO - Journal of Urban Health: Bulletin of the New York Academy of Medicine
JF - Journal of Urban Health: Bulletin of the New York Academy of Medicine
Y1 - 2006///
VL - 83
IS - 5
SP - 835
EP - 848
CY - New York; USA
PB - Springer-Verlag
SN - 1099-3460
AD - Wolff, N.: Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ 08901, USA.
N1 - Accession Number: 20073169795. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Public Health
N2 - People in prison are exposed to and experience sexual violence inside prisons, further exposing them to communicable diseases and trauma. The consequences of sexual violence follow the individual into the community upon release. This paper estimates the prevalence of sexual victimization within a state prison system. A total of 6,964 men and 564 women participated in a survey administered using audio-CASI. Weighted estimates of prevalence were constructed by gender and facility size. Rates of sexual victimization varied significantly by gender, age, perpetrator, question wording, and facility. Rates of inmate-on-inmate sexual victimization in the previous 6 months were highest for female inmates (212 per 1,000), more than four times higher than male rates (43 per 1,000). Abusive sexual conduct was more likely between inmates and between staff and inmates than nonconsensual sexual acts. Sexual violence inside prison is an urgent public health issue needing targeted interventions to prevent and ameliorate its health and social consequences, which spatially concentrate in poor inner-city areas where these individuals ultimately return.
KW - aggressive behaviour
KW - behaviour
KW - correctional institutions
KW - human behaviour
KW - human diseases
KW - infectious diseases
KW - men
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aggressive behavior
KW - behavior
KW - communicable diseases
KW - human behavior
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073169795&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/96m361111804422j/?p=cc939faf064e41718dc63b3638993fa4&pi=7
UR - email: nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The regulatory process to revise nutrient labeling relative to the Dietary Reference Intakes.
AU - Schneeman, B.
AU - Trumbo, P.
AU - Ellwood, K.
AU - Satchell, F.
A2 - Fulgoni, V. L., III
A2 - Miller, G. D.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2006///
VL - 83
IS - 5(S)
SP - 1228s
EP - 1230s
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Schneeman, B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, CFSAN-ONPLDS, HFS-800, 5100 Paint Branch Parkway, College Park, Maryland, USA.
N1 - Accession Number: 20063126161. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - The Nutrition Labeling and Education Act of 1990 - an amendment to the Federal Food, Drug, and Cosmetic Act - paved the way for significant changes in the labeling of foods, nutrient content, and health claims. This article gives an overview of the regulatory process used by the US Food and Drug Administration to revise the food label relative to the Dietary Reference Intakes and in ways that reflect new scientific knowledge and public health issues.
KW - dietary guidelines
KW - food legislation
KW - foods
KW - law
KW - public health
KW - recommended dietary allowances
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - legal aspects
KW - legal principles
KW - nutrition labelling
KW - RDA
KW - recommended dietary intakes
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063126161&site=ehost-live&scope=site
UR - email: bschneem@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims.
AU - Trumbo, P. R.
AU - Ellwood, K. C.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2006///
VL - 84
IS - 5
SP - 971
EP - 974
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Trumbo, P. R.: Division of Nutrition Programs and Labeling, Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20073008571. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 127-40-2, 144-68-3. Subject Subsets: Human Nutrition; Public Health
N2 - The labeling of health claims that meet the significant scientific agreement standard and of qualified health claims on conventional foods and dietary supplements requires premarket approval by the Food and Drug Administration (FDA). The FDA conducts an evidence-based review to ascertain whether sufficient evidence exists to support a significant scientific agreement standard or a qualified health claim. The FDA recently reviewed intervention and observational studies that evaluated the role of lutein and zeaxanthin in reducing the risk of age-related macular degeneration and cataracts. On the basis of this evidence-based review, the FDA concluded that no credible evidence exists for a health claim about the intake of lutein or zeaxanthin (or both) and the risk of age-related macular degeneration or cataracts.
KW - cataract
KW - diets
KW - eye diseases
KW - eyes
KW - human diseases
KW - risk factors
KW - xanthophyll
KW - zeaxanthin
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lutein
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073008571&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: paula.trumbo@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge.
AU - Calvert, A. E.
AU - Huang, C. Y. H.
AU - Kinney, R. M.
AU - Roehrig, J. T.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 2006///
VL - 87
IS - 2
SP - 339
EP - 346
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-1317
AD - Calvert, A. E.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention (CDC), Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063014238. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - Chimeric (D2/WN) viruses containing the pre-membrane (prM) and envelope (E) proteins of West Nile virus (WN virus) and the capsid (C) and non-structural proteins of dengue 2 (DEN2) virus were used to evaluate the protective immunity elicited by either the flaviviral E protein or non-structural proteins. AG129 interferon-deficient mice, previously shown to be protected against lethal DEN1 or DEN2 viral infection after vaccination with a wild-type or candidate vaccine strain of DEN1 or DEN2 virus, respectively, were immunized with chimeric D2/WN virus and then challenged with DEN2 virus. D2/WN chimeric viruses were non-pathogenic in AG129 mice. These viruses elicited little anti-DEN E antibody, high levels of anti-DEN NS1 antibody and no or very low levels of DEN2 virus-neutralizing antibodies. Only 15% of D2/WN-immunized mice survived challenge with DEN2 virus. However, their mean survival time increased by 11-14 days over non-immunized controls. These results suggest that, whilst the non-structural proteins were able to enhance mean survival times of AG129 mice, this protection was not as effective as protection mediated by the E protein.
KW - animal models
KW - antibodies
KW - dengue
KW - disease models
KW - immune response
KW - immunity
KW - immunization
KW - neutralizing antibodies
KW - viral proteins
KW - Dengue 2 virus
KW - mice
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063014238&site=ehost-live&scope=site
UR - http://vir.sgmjournals.org
UR - email: zpz0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A humanized murine monoclonal antibody protects mice either before or after challenge with virulent Venezuelan equine encephalomyelitis virus.
AU - Hunt, A. R.
AU - Frederickson, S.
AU - Hinkel, C.
AU - Bowdish, K. S.
AU - Roehrig, J. T.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 2006///
VL - 87
IS - 9
SP - 2467
EP - 2476
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-1317
AD - Hunt, A. R.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063140283. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 308067-58-5. Subject Subsets: Medical & Veterinary Entomology
N2 - A humanized monoclonal antibody (mAb) has been developed and its potential to protect from or cure a Venezuelan equine encephalomyelitis virus (VEEV) infection was evaluated. The VEEV-neutralizing, protective murine mAb 3B4C-4 was humanized using combinatorial antibody libraries and phage-display technology. Humanized VEEV-binding Fabs were evaluated for virus-neutralizing capacity, then selected Fabs were converted to whole immunoglobulin (Ig) G1, and stable cell lines were generated. The humanized mAb Hy4-26C, designated Hy4 IgG, had virus-neutralizing capacity similar to that of 3B4C-4. Passive antibody protection studies with purified Hy4 IgG were performed in adult Swiss Webster mice. As little as 100 ng Hy4 IgG protected 90% of mice challenged with 100 intraperitoneal (i.p.) mean morbidity (MD50) doses of virulent VEEV (Trinidad donkey) 24 h after antibody transfer; also, 500 µg Hy4 IgG protected 80% of mice inoculated with 100 intranasai MD50 doses of VEEV. Moreover, 10 µg passive Hy4 IgG protected 70% of mice from a VEEV challenge dose as great as 107 i.p. MD50. Hy4 IgG also protected mice from challenge with another epizootic VEEV variety, 1C (P676). Importantly, therapeutic administration of the humanized mAb to mice already infected with VEEV cured 90% of mice treated with Hy4 IgG within 1 h of VEEV inoculation and 75% of mice treated 24 h after virus infection.
KW - disease models
KW - experimental infections
KW - IgG
KW - immunotherapy
KW - laboratory animals
KW - monoclonal antibodies
KW - neutralizing antibodies
KW - passive immunization
KW - virus neutralization
KW - mice
KW - Venezuelan equine encephalitis virus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - equine encephalomyelitis virus
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Venezuelan equine encephalitis
KW - Venezuelan equine encephalomyelitis
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063140283&site=ehost-live&scope=site
UR - http://vir.sgmjournals.org
UR - email: arh4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Avian virulence and thermostable replication of the North American strain of West Nile virus.
AU - Kinney, R. M.
AU - Huang, C. Y. H.
AU - Whiteman, M. C.
AU - Bowen, R. A.
AU - Langevin, S. A.
AU - Miller, B. R.
AU - Brault, A. C.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 2006///
VL - 87
IS - 12
SP - 3611
EP - 3622
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-1317
AD - Kinney, R. M.: Division of Vector-borne Infectious Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20073016913. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Veterinary Science; Poultry; Veterinary Science; Medical & Veterinary Entomology
N2 - The NY99 genotype of West Nile virus (WNV) introduced into North America has demonstrated high virulence for American crows (AMCRs), whilst a closely related WNV strain (KEN-3829) from Kenya exhibits substantially reduced virulence in AMCRs [Brault, A. C., Langevin, S. A., Bowen, R. A., Panella, N. A., Biggerstaff, B. J., Miller, B. R. & Nicholas, K. (2004). Emerg Infect Dis 10, 2161-2168]. Viruses rescued from infectious cDNA clones of both the NY99 and KEN-3829 strains demonstrated virulence comparable to that of their parental strains in AMCRs. To begin to define parameters that might explain the different virulence phenotypes between these two viruses, temperature-sensitivity assays were performed for both viruses at the high temperatures experienced in viraemic AMCRs. Growth curves of the two WNV strains were performed in African green monkey kidney (Vero; 37-42°C) and duck embryonic fibroblast (DEF; 37-45°C) cells cultured at temperatures that were tolerated by the cell line. Unlike the NY99 virus, marked decreases in KEN-3829 viral titres were detected between 36 and 120 h post-infection (p.i.) at temperatures above 43°C. Replication of KEN-3829 viral RNA was reduced 6500-fold at 72 h p.i. in DEF cells incubated at 44°C relative to levels of intracellular virus-specific RNA measured at 37°C. In contrast, replication of virus derived from the NY99 infectious cDNA at 44°C demonstrated only a 17-fold reduction in RNA level. These results indicated that the ability of WNV NY99 to replicate at the high temperatures measured in infected AMCRs could be an important factor leading to the increased avian virulence and emergence of this strain of WNV.
KW - complementary DNA
KW - genotypes
KW - growth curve
KW - phenotypes
KW - strains
KW - viral replication
KW - virulence
KW - North America
KW - birds
KW - Corvus
KW - West Nile virus
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corvidae
KW - Passeriformes
KW - birds
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - America
KW - cDNA
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073016913&site=ehost-live&scope=site
UR - http://vir.sgmjournals.org
UR - email: rmk1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anaplasma phagocytophilum causes global induction of antiapoptosis in human neutrophils.
AU - Lee, H. C.
AU - Goodman, J. L.
JO - Genomics (San Diego)
JF - Genomics (San Diego)
Y1 - 2006///
VL - 88
IS - 4
SP - 496
EP - 503
CY - San Diego; USA
PB - Elsevier Academic Press
SN - 0888-7543
AD - Lee, H. C.: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063215186. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Anaplasma phagocytophilum (Ap), the agent of the tick-borne disease human granulocytic anaplasmosis, is an obligate intracellular pathogen unique in its ability to target and replicate within neutrophils. It profoundly inhibits neutrophil apoptosis, prolonging neutrophil survival from hours to days. To determine the basis of antiapoptosis, we compared gene expression in Ap-infected vs mock-infected human neutrophils. Antiapoptosis genes were consistently and significantly up-regulated (2- to 15-fold) within 1-3 h. These genes synergistically inhibit apoptosis through several interconnected pathways, including p38MAPK (MAP2K3), ERK (IER3), PI3K (PRKCD), and NF-κB (BCL2A1, NFKB1, NFKBIA, GADD45B). Both extrinsic death receptor (TNFAIP3, CFLAR, SOD2) and intrinsic mitochondrial (BCL2A1, PIM2, BIRC3) pathways were affected as confirmed by reductions in both caspase 3 and caspase 8 activities. Several important antiapoptotic genes noted to be up-regulated in Ap-infected neutrophils were not up-regulated during Ap infection of HL-60 cells (which is not antiapoptotic). In conclusion, just as apoptosis may be triggered through multiple molecular pathways, effective antiapoptosis of neutrophils is achieved rapidly and redundantly by this intracellular pathogen dependent on cell survival.
KW - anaplasmoses
KW - apoptosis
KW - cell invasion
KW - gene expression
KW - genes
KW - immune evasion
KW - in vitro
KW - molecular genetics
KW - neutrophils
KW - Anaplasma
KW - Anaplasma phagocytophilum
KW - man
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Anaplasma
KW - Anaplasma infections
KW - anaplasmosis
KW - bacterium
KW - biochemical genetics
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063215186&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG1-4KHC357-1&_user=10&_coverDate=10%2F31%2F2006&_rdoc=13&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236809%232006%23999119995%23633719%23FLA%23display%23Volume)&_cdi=6809&_sort=d&_docanchor=&view=c&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=298d79120dbc293184a77595dbdc6d8e
UR - email: jesse.goodman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improved DNA probe detection of Listeria monocytogenes in enrichment culture after physical-chemical fractionation.
AU - Duvall, R. E.
AU - Eklund, M.
AU - Tran, T. T.
AU - Hitchins, A. D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 172
EP - 179
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Duvall, R. E.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-516, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20063041920. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Bacterial detection in foods by nucleic acid probes is limited by microflora competition during selective enrichment. Probe target concentration by extraction and fractionation of enrichments may diminish this limitation. The 1-h AccuProbe chemiluminescent culture identification test for Listeria monocytogenes was used as a model. Its high detection threshold provides a stringent challenge for evaluating enrichment work-up protocols. Detection of L. monocytogenes, at 1-4 colony-forming units/g food, was not consistently possible in 48 h enrichment cultures using AccuProbe. Concentration by cell sedimentation was occasionally helpful but the volume of co-sedimented food limited concentration to about 10-fold. To improve concentration, enrichment sediments were sonicated or enzymatically lysed to release the probe's target, r-RNA. The RNA was separated from non-RNA material by extraction with phenol and precipitation with ethanol. Enrichments (250 mL) were concentrated 2500-fold, and the limitation was food RNA volume. A strongly competitive Enterococcus faecium food isolate was used to demonstrate the effect of artificial competition on the kit's ability to detect L. monocytogenes in enrichments. High competitor concentrations repressed the level of the target below the detection threshold, but concentration of r-RNA enabled detection of L. monocytogenes. The effectiveness of this enrichment sample work-up was demonstrated with naturally contaminated hummus.
KW - cereal products
KW - culture media
KW - DNA
KW - food contamination
KW - methodology
KW - microbial contamination
KW - Enterococcus faecium
KW - Listeria monocytogenes
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - bacterium
KW - deoxyribonucleic acid
KW - food contaminants
KW - hummus
KW - methods
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041920&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: Anthony.Hitchins@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of sample preparation and preenrichment media on the recovery of Salmonella from cantaloupes, mangoes, and tomatoes.
AU - Hammack, T. S.
AU - Johnson, M. L.
AU - Jacobson, A. P.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 180
EP - 184
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Microbiological Studies, College Park, MD 20740, USA.
N1 - Accession Number: 20063041921. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Postharvest Research; Agroforestry; Horticultural Science
N2 - Studies were conducted to determine the relative effectiveness of buffered peptone water (BPW), lactose (LAC) broth, and Universal Preenrichment (UP) broth for the recovery of Salmonella organisms from fruit rinses, whole fruit, and comminuted fruit. In the first phase, the relative effectiveness of the rinse and soak methods for the recovery of Salmonella from surface-contaminated mangoes and tomatoes was examined. Fruits were spot inoculated with single Salmonella serovars and held for 4 days at 2-6°C before analysis was initiated. The contaminated fruit was rinsed in portions of BPW, LAC broth, or UP broth. Portions from each rinse were added to its respective broth (e.g., BPW to BPW). Individual whole fruit, in their remaining broth rinses (soak method), and the fruit rinse/broths (rinse method) were incubated for 24 h at 35°C. The Bacteriological Analytical Manual (BAM) Salmonella culture method was followed thereafter. The soak method produced significantly greater numbers (P<0.05) of positive test portions than did the rinse method for the analysis of mangoes (93 versus 12) and tomatoes (85 versus 34). The 3 broths were comparable for the recovery of Salmonella for both the soak and the rinse methods for mangoes. For tomatoes, there were no significant differences among the broths for the soak method, but BPW and UP broth were significantly more productive (P<0.05) than LAC broth by the rinse method. In the second phase, the relative effectiveness of LAC broth, BPW, and UP broth for the recovery of Salmonella from comminuted fruit was examined. Fruits were contaminated with single Salmonella serovars and aged for 4 days at 2-6°C. Twenty 25 g test portions were preenriched in each of the following broths: BPW, LAC broth, and UP broth. The BAM Salmonella culture method was followed thereafter. For cantaloupes, significantly more (P<0.05) Salmonella-positive test portions were recovered with UP broth (96 Salmonella-positive test portions) and BPW (87 Salmonella-positive test portions) than with LAC broth (57 Salmonella-positive test portions). For mangoes, BPW recovered an arithmetically larger number of Salmonella-positive test portions (27 Salmonella-positive test portions) than did either LAC broth (14 Salmonella-positive test portions) or UP broth (18 Salmonella-positive test portions). For tomatoes, there were no significant differences among the broths: BPW recovered 65 Salmonella-positive test portions, UP broth recovered 62 Salmonella-positive test portions, and LAC broth recovered 60 Salmonella-positive test portions. For the analysis of whole fruit, it is recommended that the soak method be used. For whole fruit analyzed with the soak method, UP broth should be used for tomatoes and BPW should be used for mangoes. It is further recommended that UP broth be used for the analysis of comminuted cantaloupes and that BPW be used for the analysis of comminuted mangoes and tomatoes.
KW - culture media
KW - decontamination
KW - food contamination
KW - food processing
KW - fruits
KW - mangoes
KW - melons
KW - methodology
KW - microbial contamination
KW - tomatoes
KW - Cucumis melo
KW - Mangifera indica
KW - Salmonella
KW - Solanum lycopersicum
KW - Cucumis
KW - Cucurbitaceae
KW - Violales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Mangifera
KW - Anacardiaceae
KW - Sapindales
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Lycopersicon esculentum
KW - methods
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041921&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: Thomas.Hammack@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of mercury in carbon black by cold vapor atomic absorption spectrometry.
AU - Hepp, N. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 192
EP - 195
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hepp, N. M.: U.S. Food and Drug Administration, Office of Cosmetics and Colors, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063041923. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 7439-97-6.
N2 - Recently, a new color additive, D&C Black No. 2, a high-purity furnace black in the general category of carbon blacks, was listed as a color subject to batch certification by the U.S. Food and Drug Administration. A simple procedure was developed to determine mercury (Hg) in D&C Black No. 2, which is limited by specification to not more than 1 ppm Hg. The method uses partial acid digestion followed by cold vapor atomic absorption and was developed by modifying a method used for other color additives. The carbon black samples are treated with a mixture of nitric and hydrochloric acids and heated by microwave in sealed Teflon® vessels. The resulting solutions, which are stable to Hg loss for at least 1 week, are diluted and analyzed for Hg using cold vapor atomic absorption spectrometry. Validation was performed by spiking carbon black samples with inorganic Hg (HgNO3) at levels from 0.1 to 1.5 µ/g, and by analyzing 2 standard reference materials. At the specification level of 1 ppm Hg (1 µg Hg/g), the 95% confidence interval was ±0.01 ppm Hg (0.01 µg Hg/g). The method developed in this study gave good results for very difficult-to-analyze materials, such as coal standard reference materials and carbon black. By eliminating volatility and adsorption factors through the formation of HgCl4-2 complexes, one can avoid using extremely hazardous acids such as HF and HClO4.
KW - atomic absorption spectrophotometry
KW - determination
KW - food additives
KW - food colourants
KW - food contamination
KW - food safety
KW - heavy metals
KW - mercury
KW - carbon black
KW - cold vapor atomic absorption spectrometry
KW - food colorants
KW - food contaminants
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041923&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: nhepp@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Liquid chromatographic determination of N-methyl carbamate pesticide residues at low parts-per-billion levels in eggs.
AU - Schenck, F. J.
AU - Podhorniak, L. V.
AU - Hobbs, J.
AU - Casanova, J.
AU - Donoghue, D.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 196
EP - 200
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Schenck, F. J.: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20063041924. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 90-15-3, 51-03-6. Subject Subsets: Agricultural Entomology
N2 - A reversed-phase liquid chromatographic (LC) method is presented for the analysis of N-methyl carbamate pesticide residues and piperonyl butoxide in eggs at levels as low as 2 µg/kg (ppb). The study was undertaken to provide data for dietary exposure estimates used in risk analysis. The method uses an acetonitrile extraction followed by liquid-liquid partitioning and normal-phase aminopropyl solid-phase extraction column cleanup. Determination of residues is by reversed-phase LC with an inline postcolumn reaction followed by fluorescence detection. The average recoveries of 21 fortified (most at 2.0 and 20.0 ppb) N-methyl carbamate pesticide residues and the carbamate metabolite 1-naphthol from eggs ranged from 70 to 107%. Recoveries of the pesticide synergist piperonyl butoxide ranged from 63 to 106%. Single-comb White Leghorn hens were treated with the carbamate carbaryl, and the eggs subsequently produced were analysed for carbaryl and 1-naphthol residues.
KW - 1-naphthol
KW - analytical methods
KW - eggs
KW - food safety
KW - pesticide residues
KW - pesticides
KW - piperonyl butoxide
KW - risk assessment
KW - alpha-naphthol
KW - analytical techniques
KW - N-methyl carbamates
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041924&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: fschenck@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Committee on natural toxins and food allergens: marine and freshwater toxins.
AU - Hungerford, J. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 248
EP - 269
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hungerford, J. M.: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Dr SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20063041932. Publication Type: Journal Article. Language: English. Number of References: 237 ref. Registry Number: 11050-21-8, 4368-28-9. Subject Subsets: Human Nutrition
N2 - Research on the different natural toxins and allergens present in seafoods (both marine and freshwater) are presented; these include anatoxins, azaspiracids, brevetoxins, phycotoxins, ciguatoxins, domoic acids, microcystins, nodularins, okadaiates, saxitoxins, tetrodotoxins and yessotoxins. Discussions on the different microorganisms that produce these toxins are presented as well. Also, studies on the analytical methods used for the determination of these toxins in seafoods are discussed.
KW - analytical methods
KW - ciguatoxin
KW - fish toxins
KW - food contamination
KW - microbial contamination
KW - seafoods
KW - tetrodotoxin
KW - analytical techniques
KW - anatoxins
KW - azaspiracids
KW - brevetoxins
KW - domoic acid
KW - food contaminants
KW - microcystins
KW - nodularins
KW - okadaiates
KW - phycotoxins
KW - saxitoxin
KW - yessotoxin
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041932&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: james.Hungerford@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins.
AU - Trucksess, M. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 270
EP - 284
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063041933. Publication Type: Journal Article. Language: English. Number of References: 196 ref. Registry Number: 518-75-2, 18172-33-3, 149-29-1, 17924-92-4. Subject Subsets: Medical & Veterinary Mycology; Plant Pathology
N2 - Research on the different mycotoxins that contaminate food products are presented; these mycotoxins include aflatoxins, alternaria toxins, citrinin, cyclopiazonic acid, ergot alkaloids, fumonisins, ochratoxins, patulin, trichothecenes and zearalenone. Also, discussions on the yeast/fungal species that produce these mycotoxins are presented. The methods used for the analysis of these mycotoxins, especially in their determination in food, are discussed as well.
KW - aflatoxins
KW - analytical methods
KW - citrinin
KW - cyclopiazonic acid
KW - ergot alkaloids
KW - food contamination
KW - fumonisins
KW - microbial contamination
KW - mycotoxins
KW - ochratoxins
KW - patulin
KW - trichothecenes
KW - yeasts
KW - zearalenone
KW - fungi
KW - eukaryotes
KW - analytical techniques
KW - ergot derivatives
KW - f-2 toxin
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041933&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: mtruckse@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Committee on microbiology and extraneous materials: food microbiology, nondairy.
AU - Andrews, W. H.
AU - Hammack, T. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 1
SP - 304
EP - 318
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Andrews, W. H.: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063041938. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; Poultry; Medical & Veterinary Mycology
N2 - Research on the different assays used for the detection of microbial contamination and presence of toxins in foods are presented. The methods include colorimetry, immunoassays, culture media and molecular methods, for the determination of yeasts, moulds and bacteria (Escherichia coli and Salmonella). The use of molecular assays for the detection of Escherichia coli O157:H7 in selected nondairy foods (e.g. poultry, seafoods, meat products) is highlighted.
KW - analytical methods
KW - bacterial toxins
KW - eggs
KW - food contamination
KW - food microbiology
KW - immunoassay
KW - immunological techniques
KW - meat
KW - meat products
KW - microbial contamination
KW - moulds
KW - poultry products
KW - seafoods
KW - yeasts
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Salmonella
KW - fungi
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia coli
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - food contaminants
KW - fungus
KW - molds
KW - serological techniques
KW - Meat Produce (QQ030)
KW - Eggs and Egg Products (QQ040)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041938&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: wallace.andrews@cfsan.fda.gov\thomas.hammack@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of Griess reagent containing vanadium(III) for post-column derivatization and simultaneous determination of nitrite and nitrate in baby food.
AU - Casanova, J. A.
AU - Gross, L. K.
AU - McMullen, S. E.
AU - Schenck, F. J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 2
SP - 447
EP - 451
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Casanova, J. A.: Southeast Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth St NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20063098185. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 14797-55-8, 10102-43-9, 7440-62-2. Subject Subsets: Human Nutrition
N2 - An ion chromatographic method with post-column derivatization and spectrophotometric detection is presented for the determination of nitrate and nitrite (NOx) in baby food. NOx residues found naturally or added as preservatives were extracted from baby foods and determined by using ion chromatography with post-column derivatization and spectrophotometric detection. Nitrate was reduced to nitrite online by post-column reduction using vanadium(III) chloride and heat. Nitrite reacted with Griess reagent to produce a dye that was detected at 525 nm. The use of V(III) and heat to promote the reduction of nitrate to nitrite online is a novel feature of this detection system. The determination of incurred NOx residues in samples by using AOAC Method 993.03 yielded results comparable to those obtained by ion chromatography with spectrophotometric detection. The toxic and carcinogenic metal cadmium used in the AOAC Method to reduce the nitrate to nitrite was avoided. The proposed method provides simultaneous determination of nitrate and nitrite. Average recoveries of nitrate and nitrite residues ranged from 82 to 107% for fortification levels of 25-400 ppm.
KW - analytical methods
KW - chromatography
KW - food composition
KW - food quality
KW - infant foods
KW - nitrate
KW - nitric oxide
KW - nitrite
KW - quantitative analysis
KW - quantitative techniques
KW - residues
KW - spectrophotometry
KW - vanadium
KW - analytical techniques
KW - baby foods
KW - Aquatic Produce (QQ060)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063098185&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: fschenck@ora.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column cleanup and liquid chromatography with fluorescence detection.
AU - Trucksess, M.
AU - Weaver, C.
AU - Oles, C.
AU - D'Ovidio, K.
AU - Rader, J.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 3
SP - 624
EP - 630
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M.: U.S. Food and Drug Administration, 5300 Paint Branch Pkwy, College Park, Maryland, USA.
N1 - Accession Number: 20063107166. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Postharvest Research; Aromatic & Medicinal Plants
N2 - Mycotoxins are toxic secondary metabolites produced by certain molds and are common contaminants of many important food crops, such as grains, nuts, and spices. Some mycotoxins are found in fruits, vegetables, and botanical roots. These contaminants have a broad range of toxic effects, including carcinogenicity, immunotoxicity, neurotoxicity, and reproductive and developmental toxicity. The public health concerns related to both acute and chronic effects of mycotoxins in animals have prompted more than 100 countries to establish regulatory limits for some of the well-known mycotoxins, such as the aflatoxins (AFL). Our research focused on method development for 2 of these toxins, AFL and ochratoxin A (OTA), in ginseng and other selected botanical roots. Methods using an immunoaffinity column (IAC) cleanup, liquid chromatographic separation, and fluorescence detection were modified and evaluated. Two types of IAC cleanup were evaluated: IAC for AFL, and IAC for both AFL and OTA. Three derivatization techniques to enhance the fluorescence of the AFL were compared: precolumn trifluoroacetic acid, postcolumn bromination, and postcolumn ultraviolet irradiation. No derivatization was needed for OTA. Results for AFL using the single analyte IAC cleanup and the 3 derivatization techniques were all comparable for ginseng and for other roots such as ginger, licorice, and kava-kava. Recoveries of added AFL for ginseng at levels from 2 to 16 ng/g were about 80%. Using IAC cleanup for both AFL and OTA recoveries of added AFL for ginseng at 4-16 ng/g were about 70%, and for ginger, licorice, and kava-kava were about 60%. Recoveries of added OTA for ginseng, ginger, and echinacea at 4 ng/g were about 55%.
KW - aflatoxins
KW - analytical methods
KW - fluorescence
KW - ginger
KW - liquid chromatography
KW - liquorice
KW - medicinal plants
KW - mycotoxins
KW - ochratoxins
KW - Echinacea purpurea
KW - Glycyrrhiza
KW - Glycyrrhiza glabra
KW - Panax quinquefolius
KW - Piper methysticum
KW - Zingiber
KW - Zingiber officinale
KW - Echinacea
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Glycyrrhiza
KW - Panax
KW - Araliaceae
KW - Apiales
KW - Piper
KW - Piperaceae
KW - Piperales
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - Zingiber
KW - analytical techniques
KW - Araliales
KW - drug plants
KW - fungal toxins
KW - licorice
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063107166&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: mary.trucksess@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of cashew nut DNA in spiked baked goods using a real-time polymerase chain reaction method.
AU - Brzezinski, J. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 4
SP - 1035
EP - 1038
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Brzezinski, J. L.: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Dr, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20063146404. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - The detection of potentially allergenic foods, such as tree nuts, in food products is a major concern for the food processing industry. A real-time polymerase chain reaction (PCR) method was designed to determine the presence of cashew DNA in food products. The PCR amplifies a 67 bp fragment of the cashew 2S albumin gene, which is detected with a cashew-specific, dual-labeled TaqMan probe. This reaction will not amplify DNA derived from other tree nut species, such as almond, Brazil nut, hazelnut, and walnut, as well as 4 varieties of peanut. This assay was sensitive enough to detect 5 pg purified cashew DNA as well as cashew DNA in a spiked chocolate cookie sample containing 0.01% (100 mg/kg) cashew.
KW - allergens
KW - assays
KW - bakery products
KW - cashews
KW - detection
KW - DNA
KW - food allergies
KW - polymerase chain reaction
KW - Anacardium occidentale
KW - Anacardium
KW - Anacardiaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - baked goods
KW - deoxyribonucleic acid
KW - food hypersensitivity
KW - PCR
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063146404&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: jennifer.brzezinski@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of isoflavones in foods and dietary supplements.
AU - Delmonte, P.
AU - Rader, J. I.
A2 - Gilani, G. S.
A2 - Betz, J. M.
T3 - Special Guest Editor Section: Role of accurate methodology in demonstrating the safety and efficacy of phytoestrogens
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 4
SP - 1138
EP - 1146
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Delmonte, P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling and Dietary Supplements, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063152862. Publication Type: Journal Article. Note: Special Guest Editor Section: Role of accurate methodology in demonstrating the safety and efficacy of phytoestrogens Language: English. Number of References: 47 ref. Registry Number: 486-66-8, 446-72-0. Subject Subsets: Soyabeans; Human Nutrition; Aromatic & Medicinal Plants; Grasslands & Forage
N2 - Isoflavones are phytochemicals found in many plants. Because of their structural similarity to β-estradiol, health benefits of isoflavones have been evaluated in age-related and hormone-dependent diseases. Daidzein, genistein, and glycitein are present as free forms or derivatives in foods containing soy or soy protein extracts. The analysis of isoflavones has become more complex, because preparations contain isoflavones from multiple sources (e.g., red clover, kudzu). Red clover contains primarily formononetin and biochanin A, while kudzu extracts, which are becoming increasingly common in dietary supplements, contain puerarin and daidzein, among other components. Isoflavones are present in foods and dietary supplements as free compounds, glucoside derivatives, 6″-O-malonyl-7-O-β-D-glucoside derivatives, and 6″-O-acetyl-7-O-β-D-glucoside derivatives. High-performance liquid chromatography (HPLC)/tandem mass spectrometry has been applied to the identification of isoflavone derivatives based on the fragmentation pattern of the parent ion, providing high selectivity and sensitivity in the quantitation of isoflavones in complex mixtures. HPLC with ultraviolet detection is often chosen for routine analysis, but a preliminary acid or basic hydrolysis of isoflavone derivatives is often required for the investigation of samples containing extracts from multiple sources. Several internal standards have been used in the analysis of isoflavones from a single botanical source (e.g., soy, red clover), but the identification of a general internal standard remains a challenging process.
KW - analytical methods
KW - daidzein
KW - diet
KW - food supplements
KW - foods
KW - GC-MS
KW - genistein
KW - HPLC
KW - hydrolysis
KW - isoflavones
KW - mass spectrometry
KW - soyabean products
KW - techniques
KW - Pueraria montana
KW - Pueraria montana var. lobata
KW - Pueraria thunbergiana
KW - Trifolium pratense
KW - Pueraria
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Trifolium
KW - Pueraria montana
KW - analytical techniques
KW - biochanin A
KW - gas chromatography-mass spectrometry
KW - glycitein
KW - high performance liquid chromatography
KW - soybean products
KW - Field Crops (FF005) (New March 2000)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Diet Studies (VV110)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063152862&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: pierluigi.delmonte@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantification of tamoxifen and metabolites and soy isoflavones in human plasma using liquid chromatography with electrospray ionization tandem mass spectrometry.
AU - Williams, L. D.
AU - Twaddle, N. C.
AU - Churchwell, M. I.
AU - Doerge, D. R.
A2 - Gilani, G. S.
A2 - Betz, J. M.
T3 - Special Guest Editor Section: Role of accurate methodology in demonstrating the safety and efficacy of phytoestrogens
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 4
SP - 1168
EP - 1173
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Williams, L. D.: U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063152865. Publication Type: Journal Article. Note: Special Guest Editor Section: Role of accurate methodology in demonstrating the safety and efficacy of phytoestrogens Language: English. Number of References: 18 ref. Registry Number: 486-66-8, 446-72-0, 10540-29-1. Subject Subsets: Public Health; Soyabeans; Human Nutrition
N2 - Tamoxifen is an important estrogen receptor antagonist used successfully for the treatment and prevention of breast cancer. The use of complementary and alternative medicines is an increasingly popular means for patients to participate in their own health care, and soy products, which contain phytoestrogens, have been widely promoted for possible beneficial effects on menopausal symptoms. The possibility that soy isoflavones could reduce tamoxifen efficacy has been demonstrated in animal models of post-menopausal breast cancer, but the occurrence of such an effect in women has not been explored. This paper describes the development and validation of a sensitive method using solid-phase extraction and isotope dilution liquid chromatography/tandem mass spectrometry with multiple reaction monitoring for the concurrent analysis of the major soy isoflavones (genistein and daidzein), an important metabolite of daidzein (equol), tamoxifen, and its important metabolites (4-hydroxytamoxifen, N-desmethyltamoxifen, and 4-hydroxy-N-desmethyltamoxifen or "endoxifen") in the serum of rats and women. The limits of quantification achieved are sufficient to determine accurately and precisely the concentrations of all of these analytes in women consuming soy foods and/or therapeutic doses of tamoxifen at levels consistent with modulation of estrogen receptor-mediated functions. These procedures enable future investigations of the possible impact of diet on the outcome of breast cancer therapy.
KW - analytical methods
KW - breast
KW - breast cancer
KW - daidzein
KW - genistein
KW - human diseases
KW - isotope dilution
KW - liquid chromatography
KW - mass spectrometry
KW - neoplasms
KW - oestrogen receptors
KW - soyabean products
KW - tamoxifen
KW - techniques
KW - women
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - biochanin A
KW - breasts
KW - cancers
KW - estrogen receptors
KW - soybean products
KW - United States of America
KW - Techniques and Methodology (ZZ900)
KW - Food Composition and Quality (QQ500)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063152865&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: daniel.doerge@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Two rapid methods for detection of Escherichia coli exceeding 104/g action levels: precollaborative study.
AU - Grant, M. A.
AU - Wernberg, J. S.
AU - Van, K. T.
AU - Albert, A. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 5
SP - 1317
EP - 1326
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Grant, M. A.: U.S. Food and Drug Administration, Pacific Regional Laboratory, Northwest, Bothell, WA 98021, USA.
N1 - Accession Number: 20063196914. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - The current AOAC Method 966.24 for enumeration of Escherichia coli in foods uses a most probable number (MPN) procedure with extensive confirmation steps. Two new methods based on membrane filtration (MF) were compared to the MPN reference method for detection of high levels of E. coli in 5 food types, some of which represent categories for which the U.S. Food and Drug Administration (FDA) mandates additional testing if an action level of 104/g E. coli is exceeded. Ground beef, which is not FDA regulated, was also tested. The 5 food types were all inoculated at 3 levels: 102/g, ≥104/g, and ≥105/g E. coli. An MF protocol using either m-ColiBlue24® (CB) or lauryl sulfate tryptose plus BCIG (LST/BCIG) was an effective potential alternative to the reference method. Sensitivity and specificity for both CB and LST/BCIG were 98 and 100%, respectively. Agreement between MPN and both CB and LST/BCIG was 98%. The 2 proposed methods allow completion of both presumptive and confirmatory steps in 1-3 days, whereas the reference method requires as many as 11 days. Exclusivity testing with 50 non-E. coli strains indicated 100% were correctly ruled out by the proposed protocols. Inclusivity testing was used to determine whether typical results were obtained after incubation of E. coli cultures on CB or LST/BCIG for 24 h. Of 50 E. coli strains tested, 100% yielded typical results after incubation on CB, and 98% yielded typical results after incubation on LST/BCIG.
KW - analytical methods
KW - Cheddar cheese
KW - crab meat
KW - detection
KW - food contamination
KW - foods
KW - ground beef
KW - lettuces
KW - lucerne
KW - microbial contamination
KW - rapid methods
KW - sprouts
KW - Escherichia coli
KW - Lactuca sativa
KW - Medicago
KW - Medicago sativa
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Medicago
KW - alfalfa
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063196914&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: mike.grant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Single-laboratory validation of a method for the determination of furan in foods by using static headspace sampling and gas chromatography/mass spectrometry.
AU - Nyman, P. J.
AU - Morehouse, K. M.
AU - McNeal, T. P.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006///
VL - 89
IS - 5
SP - 1417
EP - 1424
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Nyman, P. J.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-245, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063196922. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; Horticultural Science; Dairy Science
N2 - A headspace gas chromatography/mass spectrometry method was developed and validated in-house for the determination of furan in foods. The method of standard additions with d4-furan as the internal standard was used to quantitate furan. The limit of detection and limit of quantitation (LOQ) values ranged from 0.2 and 0.6 ng/g, respectively, in apple juice to 0.9 and 2.9 ng/g, respectively, in peanut butter. Recoveries were obtained at 0.5, 1, 2, and 3 times the LOQ. At 1, 2, and 3 times the LOQ, the recoveries ranged from 89.4 to 108%, and the relative standard deviations ranged from 3.3 to 17.3% for all the matrixes. For apple juice, chicken broth, and infant formula, the averaged coefficients of determination from the linear regression analyses were >0.99 with each food fortified at 0.5, 1, 2, and 3 times the LOQ. The coefficients of determination were >0.99 for green beans and 0.96 for peanut butter with the foods fortified at 1, 2, and 3 times the LOQ. Within-laboratory precision was determined by comparing the amounts of furan found in 18 samples by 2 analysts on different days with different instruments. For most of the foods, the difference between the amounts found by each analyst was <18%. The method was used to conduct a survey of >300 foods. The furan levels found ranged from none detected to 174 ng/g.
KW - analytical methods
KW - apple juice
KW - chemical composition
KW - food analysis
KW - foods
KW - furans
KW - GC-MS
KW - groundnut butter
KW - infant formulae
KW - Phaseolus vulgaris
KW - Phaseolus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - gas chromatography-mass spectrometry
KW - green bean
KW - infant formula
KW - infant formulas
KW - peanut butter
KW - snap bean
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063196922&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: patricia.nyman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Surveillance of insecticide resistance in head lice using biochemical and molecular methods.
AU - Thomas, D. R.
AU - McCarroll, L.
AU - Roberts, R.
AU - Karunaratne, P.
AU - Roberts, C.
AU - Casey, D.
AU - Morgan, S.
AU - Touhig, K.
AU - Morgan, J.
AU - Collins, F.
AU - Hemingway, J.
T2 - Archives of Disease in Childhood
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2006///
VL - 91
IS - 9
SP - 777
EP - 778
CY - London; UK
PB - BMJ Publishing Group
SN - 0003-9888
AD - Thomas, D. R.: National Public Health Service for Wales Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20073131412. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Treatment of head louse infection is primarily through topical insecticides. However, there is growing evidence of resistance. A representative population sample was tested using biochemical and molecular methods; it was shown that, in Wales, treatments containing pyrethroids are likely to be less effective in controlling head louse infection than those containing organophosphates.
KW - children
KW - human diseases
KW - insecticide resistance
KW - organophosphorus insecticides
KW - pediculosis capitis
KW - pyrethroid insecticides
KW - school children
KW - surveillance
KW - topical application
KW - UK
KW - Wales
KW - man
KW - Pediculus capitis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pediculus
KW - Pediculidae
KW - Anoplura
KW - Phthiraptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - head louse
KW - school kids
KW - schoolchildren
KW - United Kingdom
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073131412&site=ehost-live&scope=site
UR - http://adc.bmjjournals.com/
UR - email: Daniel.Thomas@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bridging disparity: a multidisciplinary approach for influenza vaccination in an American Indian community.
AU - Traeger, M.
AU - Thompson, A.
AU - Dickson, E.
AU - Provencio, A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006///
VL - 96
IS - 5
SP - 921
EP - 925
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Traeger, M.: Whiteriver Service Unit, Indian Health Service, PO Box 860, Whiteriver, AZ 85941, USA.
N1 - Accession Number: 20063126300. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Objectives. The Whiteriver Service Unit (WRSU) used proven effective methods to conduct an influenza vaccination campaign during the 2002-2003 influenza season to bridge the vaccination gap between American Indians and Alaska Natives and the US population as a whole. Methods. In our vaccination program, we used a multidisciplinary approach that included staff and community education, standing orders, vaccination of hospitalized patients, and employee, outpatient, community, and home vaccinations without financial barriers. Results. WRSU influenza vaccination coverage rates among persons aged 65 years and older, those aged 50 to 64 years, and those with diabetes were 71.8%, 49.6%, and 70.2%, respectively, during the 2002-2003 influenza season. We administered most vaccinations to persons aged 65 years and older through the outpatient clinics (63.6%) and public health nurses (30.0%). The WRSU employee influenza vaccination rate was 72.8%. Conclusions. We achieved influenza vaccination rates in targeted groups of an American Indian population that are comparable to or higher than rates in other US populations. Our system may be a useful model for other facilities attempting to bridge disparity for influenza vaccination.
KW - age groups
KW - American indians
KW - campaigns
KW - disease control
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - vaccination
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063126300&site=ehost-live&scope=site
UR - email: marc.traeger@mail.ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Longitudinal relationships between use of highly active antiretroviral therapy and satisfaction with care among women living with HIV/AIDS.
AU - Burke-Miller, J. K.
AU - Cook, J. A.
AU - Cohen, M. H.
AU - Hessol, N. A.
AU - Wilson, T. E.
AU - Richardson, J. L.
AU - Williams, P.
AU - Gange, S. J.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006///
VL - 96
IS - 6
SP - 1044
EP - 1051
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Burke-Miller, J. K.: Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 104 S Michigan Ave, Suite 900, Chicago, IL 60603, USA.
N1 - Accession Number: 20063108457. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - Objectives. We used longitudinal data to examine the roles of 4 dimensions of patient satisfaction as both predictors and outcomes of use of highly active antiretroviral therapy (HAART) among women in the United States with HIV/AIDS. Methods. Generalized estimating equations were used to analyze time-lagged satisfaction-HAART relationships over 8 years in the Women's Interagency HIV Study. Results. Multivariate models showed that, over time, HAART use was associated with higher patient satisfaction with care in general, with providers, and with access/convenience of care; however, patient satisfaction was not associated with subsequent HAART use. Symptoms of depression and poor health-related quality of life were associated with less satisfaction with care on all 4 dimensions assessed, whereas African American race/ethnicity, illegal drug use, and fewer primary care visits were associated with less HAART use. Conclusions. Our findings suggest that dissatisfaction with care is not a reason for under use of HAART among women with HIV and that providers should not be discouraged from recommending HAART to dissatisfied patients. Rather, increasing women's access to primary care could result in both increased HAART use and greater patient satisfaction.
KW - acquired immune deficiency syndrome
KW - antiviral agents
KW - health care
KW - highly active antiretroviral therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - multiple drug therapy
KW - women
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - AIDS
KW - combination drug therapy
KW - HAART
KW - human immunodeficiency virus infections
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063108457&site=ehost-live&scope=site
UR - email: jburke@psych.uic.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The impact of state laws limiting malpractice damage awards on health care expenditures.
AU - Hellinger, F. J.
AU - Encinosa, W. E.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006///
VL - 96
IS - 8
SP - 1375
EP - 1381
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Hellinger, F. J.: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Room 5319, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20063162467. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Subject Subsets: Public Health
N2 - Twenty-eight states have laws that limit payments in malpractice cases, and several studies indicate that these laws reduce the frequency and severity of malpractice claims and lower premiums. Moreover, proponents believe that such laws reduce health care expenditures by reducing the practice of defensive medicine. However, there is a dearth of empirical evidence about the impact of these laws on the cost of health care. We used multivariate models and relatively recent data to estimate the impact of state tort reform laws that directly limit malpractice damage payments on health care expenditures. Estimates from these models suggest that laws limiting malpractice payments lower state health care expenditures by between 3% and 4%.
KW - costs
KW - expenditure
KW - health care
KW - law
KW - malpractice
KW - public health
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - costings
KW - legal aspects
KW - legal principles
KW - Laws and Regulations (DD500)
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063162467&site=ehost-live&scope=site
UR - email: fhelling@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parental English proficiency and children's health services access.
AU - Yu, S. M.
AU - Huang, Z. J.
AU - Schwalberg, R. H.
AU - Nyman, R. M.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006///
VL - 96
IS - 8
SP - 1449
EP - 1455
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Yu, S. M.: Maternal and Child Health Bureau, 5600 Fishers Lane, 18A-55, Rockville, MD 20857, USA.
N1 - Accession Number: 20063162478. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - Objectives. We examined the relation between parents' level of English proficiency and their children's access to health care. Methods. Using the 2001 California Health Interview Survey, we conducted bivariate and multivariate analyses of several measures of children's access to health care (current health insurance status, usual source of care, emergency room visits, delayed or foregone care, traveling to another country for health care, and perceived discrimination in health care) and their association with parents' English proficiency. Results. Compared with English-speaking households, children in non-English-speaking households were more likely to lack health insurance, to not have doctor contact, and to go to other countries for health care and were less likely to use emergency rooms. Their parents were less likely to report their children's experiencing delayed or foregone care or discrimination in health care. Conclusion. English proficiency is a strong predictor of access to health insurance for children, and children in non-English-speaking families are especially likely to rely on other countries for their health care. English proficiency may mitigate the effects of race/ethnicity commonly observed in health care access and utilization studies.
KW - children
KW - health care
KW - health insurance
KW - health services
KW - parents
KW - public health
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - English proficiency
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063162478&site=ehost-live&scope=site
UR - email: syu@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sobering thoughts: town hall meetings on fetal alcohol spectrum disorders.
AU - Ryan, D. M.
AU - Bonnett, D. M.
AU - Gass, C. B.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006///
VL - 96
IS - 12
SP - 2098
EP - 2101
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Ryan, D. M.: Fetal Alcohol Spectrum Disorders (FASD) Center for Excellence, Substance Abuse and Mental Health Services Administration (SAMHSA), 2101 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20073013316. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Public Health
N2 - Prenatal exposure to alcohol is one of the leading causes of preventable birth defects and developmental disabilities. During the past 30 years, fetal alcohol spectrum disorders (FASD), including fetal alcohol syndrome, have gradually begun to attract attention. However, awareness and understanding of the disorders remain low, and people who are affected are seriously underserved. The FASD Center for Excellence held a series of town hall meetings in 2002 and 2003 to gauge the issues surrounding FASD nationwide. On the basis of its findings, the center proposed a series of recommendations to begin to remedy some of the deficiencies that were identified.
KW - alcohol intake
KW - alcoholism
KW - congenital abnormalities
KW - fetal alcohol syndrome
KW - fetal development
KW - human diseases
KW - mothers
KW - pregnancy
KW - prenatal period
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alcohol consumption
KW - birth defects
KW - congenital malformations
KW - gestation
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073013316&site=ehost-live&scope=site
UR - email: fasdcenter@samhsa.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Latex specific IgE: performance characteristics of the IMMULITE 2000 3gAllergy assay compared with skin testing.
AU - Biagini, R. E.
AU - MacKenzie, B. A.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - Krieg, E. F.
AU - Robertson, S. A.
AU - Hamilton, R. G.
JO - Annals of Allergy, Asthma, & Immunology
JF - Annals of Allergy, Asthma, & Immunology
Y1 - 2006///
VL - 97
IS - 2
SP - 196
EP - 202
CY - Arlington Heights; USA
PB - American College of Allergy, Asthma, & Immunology
SN - 1081-1206
AD - Biagini, R. E.: Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, CDC/NIOSH MS C-26, Robert A. Taft Laboratories, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063161254. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 37341-29-0. Subject Subsets: Public Health; Human Nutrition
N2 - Objective: To evaluate the performance of IMMULITE 2000 3gAllergy (Immulite), a third-generation, US Food and Drug Administration (FDA)-cleared, continuous random-access immunoanalyser, for the quantification of latex specific IgE. Methods: 201 stored serum samples obtained in 1998 from patients classified as having positive or negative latex puncture skin test results were measured for latex specific IgE levels using the Immulite, and these data were compared with historical results from 3 second-generation, FDA-cleared IgE antilatex assays (AlaSTAT (Ala), AutoCAP (CAP) and HY*TEC enzyme immunoassay (HT)). Results: The diagnostic performances of CAP, Ala and Immulite assays (≥0.35 kU/litre cutoff value) were equivalent in sensitivity and specificity (P>0.05). The HT assay (≥0.05 kU/litre cutoff value) was more sensitive and less specific (P<0.05). Immulite (≥0.10 kU/litre cutoff value) had greater sensitivity than Ala and CAP and greater specificity than HT (P<0.05 for both). The diagnostic efficiency was greater for Immulite than for CAP, Ala and HT (P<0.05). Conclusions: The Immulite system is superior in diagnostic performance, especially at the 0.10 kU/litre or greater cutoff level, for the diagnosis of latex allergy than the older, second-generation assays. Immulite still misclassifies 15.5% of puncture skin test-positive individuals as negative for latex specific IgE. Compared with second-generation assays, Immulite represents a technological advance, with enhanced speed and less operator intervention.
KW - allergies
KW - blood serum
KW - diagnostic techniques
KW - human diseases
KW - IgE
KW - immunodiagnosis
KW - immunological techniques
KW - latex
KW - quantitative analysis
KW - quantitative techniques
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - reagin
KW - reaginic antibodies
KW - serological diagnosis
KW - serological techniques
KW - United States of America
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063161254&site=ehost-live&scope=site
UR - http://allergy.edoc.com/
UR - email: rbiagini@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The contribution of occupational risks to the global burden of disease: summary and next steps.
AU - Fingerhut, M.
AU - Nelson, D. I.
AU - Driscoll, T.
AU - Concha-Barrientos, M.
AU - Steenland, K.
AU - Punnett, L.
AU - Prüss-Üstün, A.
AU - Leigh, J.
AU - Corvalan, C.
AU - Eijkemans, G.
AU - Takala, J.
JO - Medicina del Lavoro
JF - Medicina del Lavoro
Y1 - 2006///
VL - 97
IS - 2
SP - 313
EP - 321
CY - Fidenza; Italy
PB - Mattioli 1885 spa - Casa Editrice
SN - 0025-7818
AD - Fingerhut, M.: National Institute for Occupational Safety and Health, Room 715H, Humphrey Building, 200 Independence Avenue SW, Washington, DC 20201, USA.
N1 - Accession Number: 20063160940. Publication Type: Journal Article; Conference paper. Language: English. Language of Summary: Italian. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Background: The Comparative Risk Assessment (CRA) project of the WHO assessed worldwide mortality and morbidity in the year 2000 resulting from exposures to selected occupational hazards. This article summarizes findings of the WHO CRA project, presents the estimates of the ILO for total deaths due to work place risks, and calls for action. Objectives: Global burden estimates and counts of deaths assist ministers and other decision and policy makers to make informed decisions and to take action regarding risk reduction. Methods: The WHO CRA methodology combined the proportions of the population exposed to 5 occupational hazards (excluding numerous risks due to inadequate global data) with relative risk measures to estimate attributable fractions of the selected health outcomes for both morbidity and mortality. ILO estimates of total numbers of global work-related injury deaths apply national fatality rates to employment data for the particular country; for disease deaths ILO uses an attributable risk approach. Results: In 2000, the selected occupational risk factors were responsible worldwide for 37% of back pain, 16% of hearing loss, 13% of chronic obstructive pulmonary disease (COPD), 11% of asthma, 8% of injuries, 9% of lung cancer and 2% of leukaemia, and about 100% of pneumoconioses and mesothelioma. These selected risks at work resulted in the loss of about 24 million years of healthy life and caused 850 000 deaths worldwide, about 40% of the ILO estimate of 2.2 million total deaths. Conclusions: These global and regional analyses have identified areas where specific preventive actions are required.
KW - asthma
KW - causes of death
KW - chronic obstructive pulmonary disease
KW - human diseases
KW - leukaemia
KW - lung cancer
KW - mesothelioma
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - pneumoconioses
KW - respiratory diseases
KW - risk assessment
KW - risk factors
KW - risk reduction
KW - work places
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood cancer
KW - cancers
KW - leucaemia
KW - leukemia
KW - lung diseases
KW - pneumoconiosis
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063160940&site=ehost-live&scope=site
UR - HTTP://www.mattioli1885.com
UR - email: mfingerhut@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Investigating the suitability of the Calgary Biofilm Device for assessing the antimicrobial efficacy of new agents.
AU - Ali, L.
AU - Khambaty, F.
AU - Diachenko, G.
JO - Bioresource Technology
JF - Bioresource Technology
Y1 - 2006///
VL - 97
IS - 15
SP - 1887
EP - 1893
CY - Oxford; UK
PB - Elsevier
SN - 0960-8524
AD - Ali, L.: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, Room # BE-022, HFS-245, College Park, MD 20740, USA.
N1 - Accession Number: 20063202242. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - This study investigated the suitability of the Calgary Biofilm Device (CBD), originally designed as a test surrogate for indwelling medical devices, for assessing the efficacy of antimicrobials developed for food and food contact surface disinfection applications. The conditions for the development of uniform biofilms from pure and mixed bacterial cultures of wild type Escherichia coli and Listeria innocua were optimized. We were able to recover ~2×106 colony forming units (CFU) from the biofilms formed on the individual pegs of the device in 24 h. Further, the parameters for the consistent release of the cells from the biofilms were optimized; test showed that the number of cells released was uniform and reproducible. The consistency and reproducibility of the biofilms formed on the pegs was evaluated using scanning electron microscopy and by plate count method. The efficacies of disinfectants on cells residing in biofilms versus planktonic cells were compared. For both species, higher concentrations of disinfectants were needed to eliminate attached cells as compared with planktonic cells. This study establishes the value of the CBD for generating consistent biofilms from either pure or mixed cultures. These biofilms can be used to assess efficacies of disinfectants against cells that have colonized the surfaces of foods and food-processing equipment. Such a system could serve as a standard surrogate for evaluating new disinfectants designed to reduce or eliminate biofilms from food-contact surfaces.
KW - biofilms
KW - disinfectants
KW - efficacy
KW - equipment
KW - food contamination
KW - food hygiene
KW - food quality
KW - Escherichia coli
KW - Listeria innocua
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - bacterium
KW - E. coli
KW - food contaminants
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063202242&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09608524
UR - email: Laila.ali@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Follow-up study of medication errors reported to the Vaccine Adverse Event Reporting System (VAERS).
AU - Varricchio, F.
AU - Reed, J.
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 2006///
VL - 99
IS - 5
SP - 486
EP - 489
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0038-4348
AD - Varricchio, F.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063111447. Publication Type: Journal Article. Corporate Author: USA, Vaccine Adverse Event Reporting System Working Group Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - Background: A study was done to determine if the apparent medication errors found in the Vaccine Adverse Event Reporting System (VAERS) database are true errors, and if true errors are found, to determine what corrective action was taken. Furthermore, if a true error did not occur, we wanted to determine at what point the misinformation was entered into the system. Methods: The VAERS database was searched for reports received between July 1, 2001 and June 30, 2002 which had either been classified as "error" or the word "error" appeared in the text of the report. The database was also searched for reports which indicated that the measles-mumps-rubella (MMR), diphtheria-tetanus-pertussis (DTP), diphtheria-tetanus-acellular pertussis (DTaP) or diphtheria-tetanus-pertussis-haemophilus (DTPH) vaccinations had been administered at an age outside of the usual recommendation. Results: A total of 119 reports of possible errors were found. Follow-up was successful in 102 (86%) cases. Additional information obtained showed that 26 cases were actual medication errors. Seventy-six cases were not actual medication errors; 9 cases were physician decisions, 37 cases were data entry errors and 30 cases were reporter errors. Conclusion: The nature of the actual errors was similar to those reported previously; wrong inoculum, improper interval, wrong route of administration, and overdose. Many errors could have been prevented by more attention to detail. Remedial action usually consisted of retraining. The new requirement that all medications be bar-coded, purchasing products from different manufacturers and segregation of vials may help prevent vial confusion.
KW - adverse effects
KW - databases
KW - diphtheria
KW - diphtheria pertussis tetanus vaccines
KW - errors
KW - immunization
KW - measles
KW - measles mumps rubella vaccines
KW - mumps
KW - pertussis
KW - rubella
KW - tetanus
KW - vaccination
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - data banks
KW - German measles
KW - immune sensitization
KW - lockjaw
KW - whooping cough
KW - Information and Documentation (CC300)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063111447&site=ehost-live&scope=site
UR - http://www.smajournalonline.com
UR - email: Varricchio@comcast.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Human astroviruses in raw sewage samples in Hungary.
AU - Meleg, E.
AU - Jakab, F.
AU - Kocsis, B.
AU - Bányai, K.
AU - Melegh, B.
AU - Szucs, G.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2006///
VL - 101
IS - 5
SP - 1123
EP - 1129
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1364-5072
AD - Meleg, E.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary.
N1 - Accession Number: 20073011240. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Aims: Routine procedures for monitoring viruses in water samples have not been drawn up for the water-microbiology screening panel. Enteric viruses, including astroviruses, are able to persist under environmental conditions and may cause public health problems by contaminating natural and drinking water resources. The aim of this study was to detect human astroviruses (HAstVs) from raw wastewater samples. Methods and Results: To obtain data on whether human astroviruses are shed in the environment, 35 raw sewage samples from 22 sewage plants in different regions of Baranya County, Hungary were tested for astrovirus using a polyethylene glycol method for concentration and a guanidinium thiocyanate-silica procedure for extraction of viral RNA. Reverse transcription-polymerase chain reaction (RT-PCR) with HAstV-specific primer pairs was used for amplification and the specificity of amplicons was confirmed by nucleotide sequencing and phylogenetic analysis. Among the 35 raw sewage samples, 15 (43%) contained HAstV and by sequence analysis, 10 genotype HAstV-1 and one genotype HAstV-2 were identified. Conclusions: The high detection rate of astroviruses we encountered in this study provide convincing evidence that HAstVs circulate at a relatively high frequency in the Hungarian population. No correlation between the standard indicators of faecal pollution and the presence of HAstVs was found. Significance and Impact of the Study: Our study is the first report on detection of HAstV in sewage in Hungary and suggests that HAstV might be potent indicators of viral pollution in environmental specimens.
KW - genotypes
KW - microbial contamination
KW - nucleotide sequences
KW - sewage
KW - wastewater
KW - Hungary
KW - Human astrovirus
KW - Human astrovirus 1
KW - Human astrovirus 2
KW - Mamastrovirus
KW - Astroviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Human astrovirus
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - DNA sequences
KW - waste water
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Wastes and Refuse (XX300)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073011240&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jam
UR - email: melegedina@freemail.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
AU - Leonard, S. S.
AU - Keil, D.
AU - Mehlman, T.
AU - Proper, S.
AU - Shi, X. L.
AU - Harris, G. K.
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2006///
VL - 103
IS - 2
SP - 288
EP - 296
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0378-8741
AD - Leonard, S. S.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS/2015, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063114958. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 9007-49-2. Subject Subsets: Aromatic & Medicinal Plants; Forest Products; Forestry
N2 - Essiac, a tea reportedly developed by the Ojibwa tribe of Canada and widely publicized as a homeopathic cancer treatment, is prepared from a mixture of four herbs Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. Each of these herbs has been reported to possess antioxidant and anti-cancer activity. Essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a matter of debate. We prepared an extract of Essiac tea from a concentration of 25 mg/mL and boiled it for 10 min. From this preparation we used concentrations of 5, 10, 25 and 50% to measure Essiac effects. In this study, we examined the effects of Essiac on free radical scavenging and DNA damage in a non-cellular system, as well as the effects Essiac on lipid peroxidation using the RAW 264.7 cell line. We observed, using electron spin resonance, that Essiac effectively scavenged hydroxyl, up to 84% reduction in radical signal at the 50% tea preparation concentration, and superoxide radicals, up to 82% reduction in radical signal also at the 50% tea preparation concentration, as well as prevented hydroxyl radical-induced DNA damage. In addition, Essiac inhibited hydroxyl radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac.
KW - antioxidant properties
KW - DNA
KW - free radicals
KW - in vitro
KW - lipid peroxidation
KW - non-wood forest products
KW - plant extracts
KW - traditional medicines
KW - Arctium lappa
KW - mice
KW - Rheum officinale
KW - Rumex acetosella
KW - Ulmus rubra
KW - Arctium
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Rheum
KW - Polygonaceae
KW - Polygonales
KW - Rumex
KW - Ulmus
KW - Ulmaceae
KW - Urticales
KW - anti-oxidant properties
KW - deoxyribonucleic acid
KW - minor forest products
KW - non-timber forest products
KW - sheep sorrel
KW - slippery elm
KW - Non-wood Forest Products (KK540)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063114958&site=ehost-live&scope=site
UR - email: SEL5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Moulds, yeasts and aerobic plate counts in ginseng supplements.
AU - Tournas, V. H.
AU - Katsoudas, E.
AU - Miracco, E. J.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006///
VL - 108
IS - 2
SP - 178
EP - 181
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073114896. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Mycology; Aromatic & Medicinal Plants; Human Nutrition
N2 - Forty six ginseng supplement samples including Siberian ginseng root, Chinese ginseng herb and root, and American ginseng root and extract were purchased from retail in the Washington, DC area and from Penn Herb Co. (Philadelphia, PA) and tested for mould and yeast (MY) contamination and the presence of aerobic mesophilic bacteria (APC). Results indicated that 100% of the Siberian ginseng samples were contaminated with fungi and bacteria. MY counts ranged from 8.0×102 to 1.4×103 cfu/g whereas the APCs were between 2.3×104 and 1.0×106 cfu/g. Most common fungi encountered in this commodity were Penicillium spp., Eurotium rubrum, E. chevalieri and Rhizopus spp. Seventy-eight percent of the Chinese ginseng herb samples were contaminated with fungi and 89% with bacteria at levels ranging between <100 and 6.0×104 and <100 and 1.2×106 cfu/g, respectively. Moulds commonly isolated were Alternaria alternata, Aspergillus niger, Aspergillus spp., Cladosporium spp., E. chevalieri, Penicillium spp. and Rhizopus spp. Fifty six percent of the Chinese ginseng root samples tested contained fungi (A. niger, Rhizopus spp. and yeasts), and 100% contained bacteria. Fungal counts ranged between <100 and 1.4×103 cfu/g and APCs were between 3.0×102 and 6.8×105 cfu/g. Forty-eight percent of the American ginseng root samples contained moulds and 30% showed bacterial contamination. MY counts were between <100 and 4.3×105 cfu/g whereas APCs were between <100 and 4.5×104 cfu/g. A. flavus was isolated from 9% and Penicillium spp. were recovered from 39% of the tested samples. This is the first report of A. flavus contamination in ginseng supplements. No moulds or yeasts were found in ginseng extract, but 50% of these samples contained bacteria at levels ranging between <100 and 1.0×103 cfu/g.
KW - aerobes
KW - food contamination
KW - food supplements
KW - microbial contamination
KW - moulds
KW - plate count
KW - yeasts
KW - Alternaria alternata
KW - Aspergillus
KW - Aspergillus niger
KW - Cladosporium
KW - Eurotium
KW - Mucoraceae
KW - Panax ginseng
KW - Penicillium
KW - Rhizopus
KW - Trichocomaceae
KW - fungi
KW - eukaryotes
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Aspergillus
KW - Davidiellaceae
KW - Capnodiales
KW - Panax
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Eurotium
KW - aerobic micro-organisms
KW - aerobic microorganisms
KW - Araliales
KW - Eurotium chevalieri
KW - Eurotium rubrum
KW - food contaminants
KW - fungus
KW - Hyphomycetes
KW - molds
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073114896&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-4J3NXXW-2&_user=10&_coverDate=04%2F25%2F2006&_rdoc=5&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235061%232006%23998919997%23620753%23FLA%23display%23Volume)&_cdi=5061&_sort=d&_docanchor=&view=c&_ct=22&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c0e72bf2471051302308bc7ea06116ed
UR - email: vtournas@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbiological quality of randomly selected ready-to-eat foods sampled between 2003 and 2005 in Wales, UK.
AU - Meldrum, R. J.
AU - Smith, R. M. M.
AU - Ellis, P.
AU - Garside, J.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006///
VL - 108
IS - 3
SP - 397
EP - 400
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, UK.
N1 - Accession Number: 20063088835. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Since 1995, the publicly funded ready-to-eat food sampling and examination activities in Wales have been coordinated and structured, using a novel approach for the identification of samples and premises. The latest set of data from this surveillance system reports the results from 3391 ready-to-eat foods sampled between November 2003 and March 2005. During this seventeen-month period all samples were examined for aerobic colony count, Escherichia coli, Listeria spp., Bacillus cereus, Salmonella, Staphylococcus aureus and Listeria monocytogenes. The food types with the poorest microbiological quality were cream cakes, custard slices and egg mayonnaise sandwiches. The food type with the best microbiological quality was dried fruit. In conclusion, the results indicate that, in general terms, the ready-to-eat food types sampled and examined in this period posed little bacterial hazard to consumers.
KW - cakes
KW - custard
KW - eggs
KW - food quality
KW - food safety
KW - foods
KW - fruits
KW - UK
KW - Bacillus cereus
KW - Escherichia coli
KW - Listeria
KW - Listeria monocytogenes
KW - Salmonella
KW - Staphylococcus aureus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Listeriaceae
KW - Listeria
KW - Staphylococcus
KW - Staphylococcaceae
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterium
KW - Britain
KW - E. coli
KW - ready-to-eat foods
KW - United Kingdom
KW - Milk and Dairy Produce (QQ010)
KW - Eggs and Egg Products (QQ040)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063088835&site=ehost-live&scope=site
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining the microbiological criteria for lot rejection from the performance objective or food safety objective.
AU - Whiting, R. C.
AU - Rainosek, A.
AU - Buchanan, R. L.
AU - Miliotis, M.
AU - LaBarre, D.
AU - Long, W.
AU - Ruple, A.
AU - Schaub, S.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006///
VL - 110
IS - 3
SP - 263
EP - 267
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Whiting, R. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063160425. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The Microbiological Criteria (MC) is a set of parameters used to determine whether a specific lot of food is acceptable or not. These parameters are the microbial test protocol and its sensitivity, the confidence level that an unacceptable lot will be detected, the number of samples to be taken and the number of positive samples that are allowed before rejecting the lot. Determining the microbiological criteria begins with knowledge of the distribution of contamination from samples within a lot, particularly within a lot that is just at the unacceptable level of the microbial hazard. The just unacceptable lot can be defined by the Food Safety Objective (FSO) or Performance Objectives (PO), the small fraction of samples that can exceed these values and the standard deviation of the samples from the lot. With this information, a microbial test protocol is chosen to have a sensitivity level that would detect between approximately 15% and 45% of the samples. A confidence level for the MC and the number of positive samples that would be acceptable (c value which is usually zero) are also chosen. With this information the number of samples (n) required can be calculated. A critical factor in setting the microbiological criteria is the sensitivity of the microbiological test (m value). The sample size (weight) and sampling procedure can affect the standard deviation of the samples, particularly foods with non-homogeneous distribution and low numbers of microorganisms. Sampling, sample preparation and analytical procedures that reduce the variation between the samples will affect the choice of m value and maximum lot mean that meets the MC.
KW - food microbiology
KW - food quality
KW - food safety
KW - quality controls
KW - quality assurance
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063160425&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01681605
UR - email: richard.whiting@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality among workers exposed to polychlorinated biphenyls (PCBs) in an electrical capacitor manufacturing plant in Indiana: an update.
AU - Ruder, A. M.
AU - Hein, M. J.
AU - Nilsen, N.
AU - Waters, M. A.
AU - Laber, P.
AU - Davis-King, K.
AU - Prince, M. M.
AU - Whelan, E.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006///
VL - 114
IS - 1
SP - 18
EP - 23
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Ruder, A. M.: National Institute for Occupational Safety and Health, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063042733. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - An electrical capacitor manufacturing cohort (n=3569) in Indiana, USA, was exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The original study of mortality through 1984 found excess melanoma and brain cancer; other studies of PCB-exposed individuals found excess non-Hodgkin lymphoma and rectal, liver, biliary tract and gallbladder cancer. Mortality was updated through 1998. Analyses included standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) using rates for Indiana and the USA, standardized rate ratios (SRRs) and Poisson regression rate ratios (RRs). Estimated cumulative exposure calculations used a new job-exposure matrix. The results showed that overall mortality overall was reduced (n=547; SMR, 0.81; 95% CI: 0.7-0.9) and non-Hodgkin lymphoma mortality was increased (n=9; SMR, 1.23; 95% CI: 0.6-2.3). Melanoma mortality remained in excess (n=9; SMR, 2.43; 95% CI: 1.1-4.6), especially in the lowest tertile of estimated cumulative exposure (n=5; SMR, 3.72; 95% CI: 1.2-8.7). Seven of the 12 brain cancer deaths (SMR, 1.91; 95% CI: 1.0-3.3) occurred after the original study. Brain cancer mortality increased with exposure (in the highest tertile, n=5; SMR, 2.71; 95% CI, 0.9-6.3); the SRR dose-response trend was significant (P=0.016). Among those working ≥90 days, both melanoma (n=8; SMR, 2.66; 95% CI: 1.1-5.2) and brain cancer (n=11; SMR, 2.12; 95% CI: 1.1-3.8) deaths were increased, especially for women: melanoma (n=3; SMR, 5.99; 95% CI: 1.2-17.5) and brain cancer (n=3; SMR, 2.87; 95% CI: 0.6-8.4). These findings of excess melanoma and brain cancer mortality confirm results of the original study. Melanoma mortality is not associated with estimated cumulative exposure, and brain cancer mortality does not demonstrate a clear dose-response relationship with estimated cumulative exposure.
KW - brain
KW - brain cancer
KW - electrical workers
KW - epidemiology
KW - exposure
KW - human diseases
KW - melanoma
KW - mortality
KW - neoplasms
KW - non-Hodgkin's lymphoma
KW - occupational hazards
KW - occupational health
KW - polychlorinated biphenyls
KW - toxic substances
KW - Indiana
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - cancers
KW - cerebrum
KW - death rate
KW - PCBs
KW - poisons
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063042733&site=ehost-live&scope=site
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Implementing a National Occupational Reproductive Research Agenda - decade one and beyond.
AU - Lawson, C. C.
AU - Grajewski, B.
AU - Daston, G. P.
AU - Frazier, L. M.
AU - Lynch, D.
AU - McDiarmid, M.
AU - Murono, E.
AU - Perreault, S. D.
AU - Robbins, W. A.
AU - Ryan, M. A. K.
AU - Shelby, M.
AU - Whelan, E. A.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006///
VL - 114
IS - 3
SP - 435
EP - 441
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Lawson, C. C.: National Institute for Occupational Safety and Health, 4676 Columbia Pkwy., R-15, Cincinnati, OH 4526-1998, USA.
N1 - Accession Number: 20063069561. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 10043-35-3. Subject Subsets: Public Health
N2 - The initial goal of occupational reproductive health research is to effectively study the many toxicants, physical agents, and biomechanical and psychosocial stressors that may constitute reproductive hazards in the workplace. Although the main objective of occupational reproductive researchers and clinicians is to prevent recognized adverse reproductive outcomes, research has expanded to include a broader spectrum of chronic health outcomes potentially affected by reproductive toxicants. To aid in achieving these goals, the National Institute for Occupational Safety and Health, along with its university, federal, industry, and labor colleagues, formed the National Occupational Research Agenda (NORA) in 1996. NORA resulted in 21 research teams, including the Reproductive Health Research Team (RHRT). In this report, we describe progress made in the last decade by the RHRT and by others in this field, including prioritizing reproductive toxicants for further study; facilitating collaboration among epidemiologists, biologists, and toxicologists; promoting quality exposure assessment in field studies and surveillance; and encouraging the design and conduct of priority occupational reproductive studies. We also describe new tools for screening reproductive toxicants and for analyzing mode of action. We recommend considering outcomes such as menopause and latent adverse effects for further study, as well as including exposures such as shift work and nanomaterials. We describe a broad domain of scholarship activities where a cohesive system of organized and aligned work activities integrates 10 years of team efforts and provides guidance for future research.
KW - boric acid
KW - environment
KW - exposure
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - occupations
KW - phthalates
KW - pregnancy
KW - reproduction
KW - reproductive health
KW - risk factors
KW - toxic substances
KW - toxicology
KW - whole body vibration
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - phthalic acid esters
KW - poisons
KW - Human Reproduction and Development (VV060)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063069561&site=ehost-live&scope=site
UR - email: clawson@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Workgroup report: review of genomics data based on experience with mock submissions - view of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee.
AU - Leighton, J. K.
AU - Brown, P.
AU - Ellis, A.
AU - Harlow, P.
AU - Harrouk, W.
AU - Pine, P. S.
AU - Robison, T.
AU - Rosario, L.
AU - Thompson, K.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006///
VL - 114
IS - 4
SP - 573
EP - 578
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Leighton, J. K.: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 22, Room 2118, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA.
N1 - Accession Number: 20063097315. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - Over the past few years, both the US Food and Drug Administration (FDA) and the pharmaceutical industry have recognized the potential importance of pharmacogenomics and toxicogenomics to drug development. To resolve the uncertainties surrounding the use of microarray technology and the presentation of genomics data for regulatory purposes, several pharmaceutical companies and genomics technology providers have provided the FDA with reports of genomics studies that included supporting toxicology data (e.g., serum chemistry, histopathology). These studies were not associated with any active drug application and were exploratory or hypothesis generating in nature. For training purposes, these reports were reviewed by the Nonclinical Pharmacogenomics Subcommittee consisting of the Center for Drug Evaluation and Research pharmacology and toxicology researchers and reviewers. In this article, we describe some of these submissions and report on our assessment of data content, format, and quality control metrics that were useful for evaluating these nonclinical genomics submissions, specifically in relation to the proposed MIAME/MINTox (minimum information about a microarray experiment/minimum information needed for a toxicology experiment) recommendations. These genomics submissions allowed both researchers and regulators to gain experience in the process of reviewing and analysing toxicogenomics data. The experience will allow development of recommendations for the submission and review of these data as the state of the science evolves.
KW - drug development
KW - genomics
KW - pharmacogenomics
KW - quality controls
KW - toxicogenomics
KW - toxicology
KW - quality assurance
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063097315&site=ehost-live&scope=site
UR - email: leightonj@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs).
AU - Prince, M. M.
AU - Ruder, A. M.
AU - Hein, M. J.
AU - Waters, M. A.
AU - Whelan, E. A.
AU - Nilsen, N.
AU - Ward, E. M.
AU - Schnorr, T. M.
AU - Laber, P. A.
AU - Davis-King, K. E.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006///
VL - 114
IS - 10
SP - 1508
EP - 1514
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Prince, M. M.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063211049. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Public Health
N2 - Background: We expanded an existing cohort of workers (n=2,588) considered highly exposed to polychlorinated biphenyls (PCBs) at two capacitor manufacturing plants to include all workers with at least 90 days of potential PCB exposure during 1939-1977 (n=14,458). Causes of death of a priori interest included liver and rectal cancers, previously reported for the original cohort, and non-Hodgkin lymphoma (NHL), melanoma, and breast, brain, intestine, stomach, and prostate cancers, based on other studies. Methods: We ascertained vital status of the workers through 1998, and cumulative PCB exposure was estimated using a new job exposure matrix. Analyses employed standardized mortality ratios (SMRs; U.S., state, and county referents) and Poisson regression modeling. Results: Mortality from NHL, melanoma, and rectal, breast, and brain cancers were neither in excess nor associated with cumulative exposure. Mortality was not elevated for liver cancer [21 deaths; SMR 0.89; 95% confidence interval (CI), 0.55-1.36], but increased with cumulative exposure (trend p-value=0.071). Among men, stomach cancer mortality was elevated (24 deaths; SMR 1.53; 95% CI, 0.98-2.28) and increased with cumulative exposure (trend p-value=0.039). Among women, intestinal cancer mortality was elevated (67 deaths; SMR 1.31; 95% CI, 1.02-1.66), especially in higher cumulative exposure categories, but without a clear trend. Prostate cancer mortality, which was not elevated (34 deaths; SMR 1.04; 95% CI, 0.72-1.45), increased with cumulative exposure (trend p-value=0.0001). Conclusions: This study corroborates previous studies showing increased liver cancer mortality, but we cannot clearly associate rectal, stomach, and intestinal cancers with PCB exposure. This is the first PCB cohort showing a strong exposure-response relationship for prostate cancer mortality.
KW - electrical workers
KW - epidemiology
KW - exposure
KW - human diseases
KW - liver
KW - liver cancer
KW - mortality
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - polychlorinated biphenyls
KW - prostate
KW - prostate cancer
KW - toxic substances
KW - Massachusetts
KW - New York
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Middle Atlantic States of USA
KW - cancers
KW - death rate
KW - PCBs
KW - poisons
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063211049&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nanoparticles: health effects - pros and cons.
AU - Gwinn, M. R.
AU - Vallyathan, V.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006///
VL - 114
IS - 12
SP - 1818
EP - 1825
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Gwinn, M. R.: National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20073029622. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of <100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. Many fine particles generally considered "nuisance dusts" are likely to acquire unique surface properties when engineered to nanosize and may exhibit toxic biological effects. Consequently, the nuisance dust may be transported to distant sites and could induce adverse health effects. In addition the beneficial uses of NPs in drug delivery, cancer treatment, and gene therapy may cause unintentional human exposure. Because of our lack of knowledge about the health effects associated with NP exposure, we have an ethical duty to take precautionary measures regarding their use. In this review we highlight the possible toxic human health effects that can result from exposure to ultrafine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes. The comparability of engineered NPs to UFPs suggests that the human health effects are likely to be similar. Therefore, it is prudent to elucidate their toxicologic effect to minimize occupational and environmental exposure. Highlighting the human health outcomes caused by UFPs is not intended to give a lesser importance to either the unprecedented technologic and industrial rewards of the nanotechnology or their beneficial human uses.
KW - adverse effects
KW - air
KW - air pollutants
KW - air pollution
KW - anticancer properties
KW - cardiovascular diseases
KW - death
KW - diagnosis
KW - diagnostic techniques
KW - drug delivery systems
KW - exposure
KW - gene therapy
KW - genes
KW - health hazards
KW - human diseases
KW - imagery
KW - lungs
KW - morbidity
KW - mortality
KW - nanoparticles
KW - neoplasms
KW - neurons
KW - neurotoxicity
KW - particles
KW - respiratory diseases
KW - reviews
KW - skin
KW - therapy
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - administration routes
KW - adverse reactions
KW - anti-cancer properties
KW - atmospheric pollution
KW - cancers
KW - death rate
KW - dermis
KW - lung diseases
KW - nerve cells
KW - neurones
KW - particulate matter
KW - therapeutics
KW - ultrafine particles
KW - Meteorology and Climate (PP500)
KW - Pollution and Degradation (PP600)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073029622&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: vav1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Birth outcomes following West Nile virus infection of pregnant women in the United States: 2003-2004.
AU - O'Leary, D. R.
AU - Kuhn, S.
AU - Kniss, K. L.
AU - Hinckley, A. F.
AU - Rasmussen, S. A.
AU - Pape, W. J.
AU - Kightlinger, L. K.
AU - Beecham, B. D.
AU - Miller, T. K.
AU - Neitzel, D. F.
AU - Michaels, S. R.
AU - Campbell, G. L.
AU - Lanciotti, R. S.
AU - Hayes, E. B.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006///
VL - 117
IS - 3
SP - e537
EP - e545
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - O'Leary, D. R.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063075036. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Background: Congenital West Nile virus (WNV) infection was first described in a single case in 2002. The proportion of maternal WNV infections resulting in congenital infection and clinical consequences of such infections are unknown. Methods: In 2003 and 2004, women in the USA who acquired WNV infection during pregnancy were reported to the Centers for Disease Control and Prevention by state health departments. Data on pregnancy outcomes were collected. One of the maternal WNV infections was identified retrospectively after the infant was born. Maternal sera, placenta, umbilical cord tissue, and cord serum were tested for WNV infection by using serologic assays and reverse-transcription polymerase chain reaction. Infant health was assessed at delivery and through 12 months of age. Results: Seventy-seven women infected with WNV during pregnancy were clinically followed in 16 states. A total of 71 women delivered 72 live infants; 4 women had miscarriages, and 2 had elective abortions. Of the 72 live infants, 67 were born at term, and 4 were preterm; gestational age was unknown for 1. Of 55 live infants from whom cord serum was available, 54 tested negative for anti-WNV IgM. One infant born with umbilical hernia and skin tags had anti-WNV IgM in cord serum but not in peripheral serum at age one month. An infant who had no anti-WNV IgM in cord blood, but whose mother had WNV illness 6 days prepartum, developed WNV meningitis at age 10 days. Another infant, whose mother had acute WNV illness at delivery, was born with a rash and coarctation of the aorta and had anti-WNV IgM in serum at one month of age; cord serum was not available. A fourth infant, whose mother had onset of WNV illness 3 weeks prepartum that was not diagnosed until after delivery, had WNV encephalitis and underlying lissencephaly detected at age 17 days and subsequently died; cord serum was not available. The following major malformations were noted among live-born infants: aortic coarctation (n=1); cleft palate (n=1); Down syndrome (n=1); lissencephaly (n=1); microcephaly (n=2); and polydactyly (n=1). One infant had glycogen storage disease type 1. Abnormal growth was noted in 8 infants. Conclusions: Of 72 infants followed to date in 2003 and 2004, almost all seemed normal, and none had conclusive laboratory evidence of congenital WNV infection. Three infants had WNV infection that could have been congenitally acquired. Seven infants had major malformations, but only 3 of these had defects that could have been caused by maternal WNV infection based on the timing of the infections and the sensitive developmental period for the specific malformations, and none had any conclusive evidence of WNV aetiology. However, the sensitivity and specificity of IgM testing of cord blood to detect congenital WNV infection are currently unknown, and congenital WNV infection among newborns with IgM-negative serology cannot be ruled out. Prospective studies comparing pregnancy outcomes of WNV-infected and -uninfected women are needed to better define the outcomes of WNV infection during pregnancy.
KW - congenital abnormalities
KW - congenital infection
KW - Down's syndrome
KW - encephalitis
KW - glycogenosis
KW - growth
KW - human diseases
KW - induced abortion
KW - infants
KW - polydactylia
KW - pregnancy
KW - spontaneous abortion
KW - women
KW - USA
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - encephalomyelitis
KW - gestation
KW - glycogen disease
KW - glycogen storage disease
KW - glycogenic hepatomegaly
KW - microcephaly
KW - miscarriage
KW - mongolism
KW - Pompe's disease
KW - prenatal infection
KW - United States of America
KW - Von Gierke's disease
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063075036&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org/cgi/content/full/117/3/e537
UR - email: doleary@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the United States.
AU - Rader, J. I.
AU - Schneeman, B. O.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006///
VL - 117
IS - 4
SP - 1394
EP - 1399
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Rader, J. I.: Division of Research & Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20063102262. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 59-30-3. Subject Subsets: Public Health; Human Nutrition
N2 - This paper reviews published data on the prevalence of neural tube defects (NTDs) in USA (1995-2002), and the folic acid (FA) status of the US population (1999-2000) after the initiation of mandatory FA fortification of cereal food products in 1998. The role of the completeness of NTD case identification in evaluating the efficacy of the fortification programme, and issues regarding the safety of FA fortification in nontarget populations and the potential adverse effects of excessive FA intake, are discussed.
KW - adverse effects
KW - cereal products
KW - cereals
KW - congenital abnormalities
KW - disease prevalence
KW - disease prevention
KW - efficacy
KW - epidemiology
KW - folic acid
KW - fortification
KW - human diseases
KW - infants
KW - neural tube defects
KW - nutrient intake
KW - nutrition programmes
KW - nutritional state
KW - pregnancy
KW - reviews
KW - safety
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - birth defects
KW - congenital malformations
KW - feeding programmes
KW - feeding programs
KW - folacin
KW - folate
KW - food fortification
KW - food programs
KW - gestation
KW - nutrition programs
KW - nutritional status
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Human Reproduction and Development (VV060)
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063102262&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: Jeanne.Rader@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changing incidence of Candida bloodstream infections among NICU patients in the United States: 1995-2004.
AU - Fridkin, S. K.
AU - Kaufman, D.
AU - Edwards, J. R.
AU - Shetty, S.
AU - Horan, T.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006///
VL - 117
IS - 5
SP - 1680
EP - 1687
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Fridkin, S. K.: MS C-09, Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Rd, Atlanta, GA 30333, USA.
N1 - Accession Number: 20063121747. Publication Type: Journal Article. Corporate Author: USA, National Nosocomial Infections Surveillance System Hospitals Language: English. Number of References: 28 ref. Registry Number: 86386-73-4. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - OBJECTIVES: Recent reports suggest that candidaemia caused by fluconazole-resistant strains is increasing in certain adult populations. We evaluated the annual incidence of neonatal candidaemia and the frequency of disease caused by different species of Candida among neonates in the United States. PATIENTS: The study included neonates admitted to 128 NICUs participating in the National Nosocomial Infections Surveillance system from 1 January 1995, to 31 December 2004 (study period). METHODS: Reports of bloodstream infection (BSI) with Candida spp.; Candida BSIs, patient admissions, patient-days, and central venous catheter days were pooled by birth weight category. The number of Candida BSIs per 100 patients (attack rate) and per 1000 patient-days (incidence density) was determined. Both overall and species-specific rates were calculated; data were pooled over time to determine the differences by birth weight category and by year to determine trends over time. RESULTS: From the 130 523 patients admitted to NICUs during the study period, there were 1997 Candida spp. BSIs reported. Overall, 1472 occurred in the <1000-g birth weight group. Candida albicans BSIs were most common, followed by Candida parapsilosis, Candida tropicalis, Candida lusitaniae, Candida glabrata, and only 3 Candida krusei. Among neonates <1000 g, incidence per 1000 patient-days decreased from 3.51 during 1995-1999 to 2.68 during 2000-2004 but remained stable among heavier neonates. No increase in infections by species that tend to demonstrate resistance to fluconazole (C. glabrata or C. krusei) was observed. CONCLUSIONS: Although Candida BSI is a serous problem among neonates <1000 g, incidence has declined over the past decade, and disease with species commonly resistant to azoles was extremely rare.
KW - antifungal agents
KW - candidosis
KW - disease incidence
KW - drug resistance
KW - epidemiology
KW - fluconazole
KW - fungaemia
KW - human diseases
KW - nosocomial infections
KW - surveillance
KW - Candida
KW - Candida acidothermophilum
KW - Candida glabrata
KW - Candida lusitaniae
KW - Candida parapsilosis
KW - Candida tropicalis
KW - man
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Candida
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Torulopsis
KW - Pezizomycotina
KW - Candida krusei
KW - candidiasis
KW - fungemia
KW - fungistats
KW - fungus
KW - hospital infections
KW - Hyphomycetes
KW - Torulopsis glabrata
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063121747&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: sfridkin@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA perspectives on supplement use by patients on antithrombotic therapy: dietary supplement regulatory overview.
AU - Woo, J. J. Y.
A2 - Marder, V. J.
A2 - Ortel, T. L.
A2 - Grollman, A.
A2 - Hasan , A. A. K.
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2006///
VL - 117
IS - 1/2
SP - 193
EP - 196
CY - New York; USA
PB - Elsevier
SN - 0049-3848
AD - Woo, J. J. Y.: Clinical Evaluation Team Leader, Division of Dietary Supplement Programs, Office of Nutritional Products, Labeling and Dietary Supplements, Food and Drug Administration, Room 4D032, CPK1 College Park, MD 20740, USA.
N1 - Accession Number: 20063207744. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
KW - anticoagulants
KW - blood coagulation
KW - food supplements
KW - labelling
KW - legislation
KW - nutrient drug interactions
KW - regulations
KW - safety
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clotting system
KW - labeling
KW - labels
KW - rules
KW - Laws and Regulations (DD500)
KW - Marketing and Distribution (EE700)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063207744&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4HDG981-1&_user=3891418&_handle=V-WA-A-W-BB-MsSAYVA-UUA-U-AAZZCUEZCE-AAZVUEUVCE-YVWDBVYU-BB-U&_fmt=full&_coverDate=12%2F31%2F2005&_rdoc=28&_orig=browse&_srch=%23toc%234887%232005%23998829998%23609882!&_cdi=4887&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=57047840066dcec35f2df8f99c3c783f
UR - email: jason.woo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA perspectives on supplement use by patients on antithrombotic therapy.
AU - Kim, M. J.
A2 - Marder, V. J.
A2 - Ortel, T. L.
A2 - Grollman, A.
A2 - Hasan , A. A. K.
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2006///
VL - 117
IS - 1/2
SP - 197
EP - 200
CY - New York; USA
PB - Elsevier
SN - 0049-3848
AD - Kim, M. J.: Senior Clinical Pharmacology and Biopharmaceutics Reviewer, Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, HFD-870, Rockville, MD 20857, USA.
N1 - Accession Number: 20063207745. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 50-78-2, 5543-58-8, 81-81-2, 129-06-6. Subject Subsets: Aromatic & Medicinal Plants; Human Nutrition
KW - adverse effects
KW - anticoagulants
KW - aspirin
KW - food supplements
KW - herb-drug interactions
KW - herbal drugs
KW - medicinal plants
KW - nutrient drug interactions
KW - vitamin supplements
KW - warfarin
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - acetylsalicylic acid
KW - adverse reactions
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063207745&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4H68T00-1&_user=3891418&_handle=V-WA-A-W-BB-MsSAYVA-UUA-U-AAZZCUEZCE-AAZVUEUVCE-YVWDBVYU-BB-U&_fmt=full&_coverDate=12%2F31%2F2005&_rdoc=29&_orig=browse&_srch=%23toc%234887%232005%23998829998%23609882!&_cdi=4887&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=6db8f0695ab4e250de04909ebbff7791
UR - email: KIMMYO@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - NAT2 slow acetylation and bladder cancer in workers exposed to benzidine.
AU - Carreón, T.
AU - Ruder, A. M.
AU - Schulte, P. A.
AU - Hayes, R. B.
AU - Rothman, N.
AU - Waters, M.
AU - Grant, D. J.
AU - Boissy, R.
AU - Bell, D. A.
AU - Kadlubar, F. F.
AU - Hemstreet, G. P., III
AU - Yin SongNian
AU - LeMasters, G. K.
JO - International Journal of Cancer
JF - International Journal of Cancer
Y1 - 2006///
VL - 118
IS - 1
SP - 161
EP - 168
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0020-7136
AD - Carreón, T.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063005303. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Tropical Diseases
N2 - This study expands a previous study of NAT2 polymorphisms and bladder cancer in male subjects occupationally exposed only to benzidine. The combined analysis of 68 cases and 107 controls from a cohort of production workers in China exposed to benzidine included 30 new cases and 67 controls not previously studied. NAT2 enzymatic activity phenotype was characterized by measuring urinary caffeine metabolite ratios. PCR-based methods identified genotypes for NAT2, NAT1 and GSTM1. NAT2 phenotype and genotype data were consistent. A protective association was observed for the slow NAT2 genotype (bladder cancer OR=0.3; 95% CI=0.1=1.0) after adjustment for cumulative benzidine exposure and lifetime smoking. Individuals carrying NAT1wt/*10 and NAT1*10/*10 showed higher relative risks of bladder cancer (OR=2.8, 95% CI=0.8-10.1 and OR=2.2, 95% CI=0.6-8.3, respectively). No association was found between GSTM1 null and bladder cancer. A metaanalysis risk estimate of case-control studies of NAT2 acetylation and bladder cancer in Asian populations without occupational arylamine exposures showed an increased risk for slow acetylators. The lower limit of the confidence interval (OR=1.4; 95% CI=1.0-2.0) approximated the upper confidence interval for the estimate obtained in our analysis. These results support the earlier finding of a protective association between slow acetylation and bladder cancer in benzidine-exposed workers, in contrast to its established link as a risk factor for bladder cancer in people exposed to 2-naphthylamine and 4-aminobiphenyl. Study findings suggest the existence of key differences in the metabolism of mono- and diarylamines.
KW - acetylation
KW - bladder
KW - bladder cancer
KW - bladder diseases
KW - chemical workers
KW - enzymes
KW - exposure
KW - genes
KW - genetic polymorphism
KW - genotypes
KW - human diseases
KW - men
KW - molecular epidemiology
KW - molecular genetics
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - risk assessment
KW - risk factors
KW - China
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - benzidine
KW - biochemical genetics
KW - cancers
KW - N-acetyltransferase 2
KW - People's Republic of China
KW - urinary bladder
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063005303&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/jhome/29331
UR - email: carreota@ucmail.uc.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women.
AU - Bonner, M. R.
AU - Bennett, W. P.
AU - Xiong, W. Y.
AU - Lan, Q.
AU - Brownson, R. C.
AU - Harris, C. C.
AU - Field, R. W.
AU - Lubin, J. H.
AU - Alavanja, M. C. R.
JO - International Journal of Cancer
JF - International Journal of Cancer
Y1 - 2006///
VL - 119
IS - 6
SP - 1462
EP - 1467
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0020-7136
AD - Bonner, M. R.: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20073100902. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 50812-37-8, 10043-92-2. Subject Subsets: Public Health
N2 - Tobacco smoke and ionizing radiation induce oxidative stress by transmitting or generating reactive oxygen species (ROS). We hypothesized that glutathione-S-transferase M1 (GSTMl1) null homozygotes would have decreased ability to neutralize ROS that might increase their susceptibility to lung cancer. A case-only design was used with lung cancer cases pooled from 3 previously completed case-control studies using archival tissue samples from 270 lung cancer cases to genotype GSTM1. Radon concentrations were measured with long-term α-track radon detectors. Second-hand smoke (SHS) was measured with questionnaires and inter-views. Unconditional logistic regression was used to calculate the interaction odds ratios (OR) and 95% confidence intervals (95% CI). Radon concentrations >121 Bq m-3 were associated with a >3-fold interaction OR (OR=3.41; 95% CI=1.10, 10.61) for GSTM1 null homozygotes compared to GSTM1 carriers; the linear trend was significant (p trend=0.03). The SHS and GSTM1 interaction OR was also elevated (OR=2.28; 95% CI=1.15-4.51) among never-smokers. This may be the first study to provide evidence of a GSTM1 and radon interaction in risk of lung cancer. Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway.
KW - genotypes
KW - glutathione transferase
KW - human diseases
KW - ionizing radiation
KW - lung cancer
KW - lungs
KW - neoplasms
KW - passive smoking
KW - radon
KW - risk factors
KW - tobacco smoking
KW - women
KW - Iowa
KW - Missouri
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - cancers
KW - ligandin
KW - United States of America
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073100902&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/jhome/29331
UR - email: mrbonner@buffalo.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Does danger lurk in the library?
AU - Atenstaedt, R. L.
JO - Public Health
JF - Public Health
Y1 - 2006///
VL - 120
IS - 8
SP - 776
EP - 777
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Atenstaedt, R. L.: National Public Health Service for Wales (NPHS) and Institute of Medical and Social Care Research (IMSCaR), Ardudwy, Normal Site, University of Wales, Bangor, Gwynedd LL57 2PX, UK.
N1 - Accession Number: 20063172039. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Protozoology; Public Health; Medical & Veterinary Mycology
N2 - A literature review was conducted on the relationship between books and the transmission of infectious diseases, to shed light on the Public Health Amendment Act in UK prohibiting persons with notifiable diseases to borrow books from public libraries. PubMed and the MeSH terms 'books' and 'disease transmission' were used. The searches produced ~20 000 citations for books and 30 000 for disease transmission. Only 11 papers were determined relevant. However, none of the papers revealed any evidence that library books transmit notifiable diseases.
KW - bacterial diseases
KW - books
KW - disease transmission
KW - epidemiology
KW - human diseases
KW - infectious diseases
KW - law
KW - mycoses
KW - protozoal infections
KW - public health
KW - reviews
KW - systematic reviews
KW - viral diseases
KW - UK
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - communicable diseases
KW - legal aspects
KW - legal principles
KW - protozoal diseases
KW - United Kingdom
KW - viral infections
KW - Laws and Regulations (DD500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063172039&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: Robert.Atenstaedt@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Health impact assessment and community involvement in land remediation decisions.
AU - Lester, C.
AU - Temple, M.
JO - Public Health
JF - Public Health
Y1 - 2006///
VL - 120
IS - 10
SP - 915
EP - 922
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Lester, C.: National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK.
N1 - Accession Number: 20063223925. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - This paper describes a collaborative health impact assessment (HIA) of land remediation options at the site of a former smokeless fuel factory, where action had been delayed by conflict between stakeholders. The likely impacts of the processes involved on the physical and mental health of the community were examined in terms of the relevant scientific and medical literature, history of the site and evidence of local people. Although all remediation options were likely to have some adverse health effects, they could be mitigated by making choices based on the best evidence. The steering group concluded that the adverse effects of remediation would be relatively short term and could be justified by the medium- to long-term benefits of removing toxic substances. The HIA steering group's recommendations were accepted by the project working group, resulting in the resolution of long-running conflict between the residents, activists and those responsible for site remediation, which has now commenced.
KW - accidents
KW - air pollution
KW - children
KW - coal
KW - employment
KW - epidemiology
KW - exposure
KW - factories
KW - human diseases
KW - mental health
KW - mental stress
KW - noise
KW - public health
KW - remediation
KW - trauma
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - atmospheric pollution
KW - Britain
KW - jobs
KW - psychological stress
KW - traumas
KW - United Kingdom
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063223925&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: carolyn.lester@nphs.wales.nhs.k
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infant mortality reviews in the Aberdeen Area of the Indian Health Service: strategies and outcomes.
AU - Eaglestaff, M. L.
AU - Klug, M. G.
AU - Burd, L.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006///
VL - 121
IS - 2
SP - 140
EP - 148
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Eaglestaff, M. L.: Aberdeen Area of the Indian Health Service, Aberdeen, South Dakota, USA.
N1 - Accession Number: 20063084190. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - Objective. To determine cause and manner of death for consecutive infant deaths in the Aberdeen Area of the Indian Health Service (AAIHS) from 1998 to 2002 and to identify risk markers for infant mortality. Methods. Infant deaths in the AAIHS were identified from four data sources: death certificates from the four states in the AAIHS, deaths reported by local IHS Service Units, from obituaries in local and regional newspapers, and deaths reported by area hospitals. Each infant death is then sent to the local IHS service unit for review, where data from the infant and mother's chart is extracted and recorded. Local community factors, birth and death certificates, and autopsy reports are collected. The case is then reviewed at the Perinatal Infant Mortality Review (PIMR) meeting and a cause and manner of death is assigned. Summary data for the cohort was examined and then compared by mortality category and three age-at-death groups. Results. Sudden infant death syndrome accounted for 33% of all infant deaths in the AAIHS. Prematurity was the second most prevalent cause-specific mortality category, accounting for 22% of all infant deaths. The authors found that infant mortality was surprisingly recurrent, with 32% of mothers of this infant having had a previous infant death. Conclusions. The PIMR committee requires substantial resources to support a review committee with appropriate expertise and their travel. Participation of local IHS staff and tribal members provides an important cultural and community perspective for the review process. Quality improvement changes are currently being implemented. These include increasing data on substance use, mental health needs, and reviews of fetal deaths. The process of mortality review has been very helpful in public education in the AAIHS.
KW - causes of death
KW - ethnic groups
KW - infant mortality
KW - infants
KW - prematurity
KW - risk factors
KW - sudden infant death syndrome
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cot death
KW - SIDS
KW - sudden infant death
KW - United States of America
KW - Demography (UU200)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063084190&site=ehost-live&scope=site
UR - email: laburd@medicine.nodak.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An occupational health services initiative at a women's hospital in Kabul, Afghanistan.
AU - Kitt, M. M.
AU - Khalid, G.
AU - Rahimi, S.
AU - McCarthy, B. J.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006///
VL - 121
IS - 6
SP - 650
EP - 657
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Kitt, M. M.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
N1 - Accession Number: 20063229414. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - This article describes the process of developing targeted occupational health services for the health care workers in a women's hospital in Kabul, Afghanistan, as a part of a larger project to establish an obstetrics and gynecology residency training program at the facility. The goal was to create a feasible and sustainable program to: (1) address basic health care needs impacting the ability of these Afghan health care workers to optimize learning opportunities; (2) decrease absenteeism due to illness; (3) decrease the likelihood of infectious disease transmission among staff, from staff to patients, and from patients to staff; (4) foster belief that a healthy and safe working environment is a basic right; (5) begin to collect preliminary health status indicators on health care workers in this employee population; and (6) serve as an adaptable program to expand to other Afghan health care workers.
KW - disease transmission
KW - gynaecology
KW - health care workers
KW - health services
KW - human diseases
KW - human rights
KW - infectious diseases
KW - learning
KW - obstetrics
KW - occupational health
KW - training
KW - Afghanistan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Asia
KW - Asia
KW - Least Developed Countries
KW - Developing Countries
KW - West Asia
KW - communicable diseases
KW - gynecology
KW - occupational health services
KW - Education and Training (CC100)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063229414&site=ehost-live&scope=site
UR - http://www.publichealthreports.org
UR - email: ajy8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK-53 virus by sequencing and quantitative TaqMAMA.
AU - Butrapet, S.
AU - Kinney, R. M.
AU - Huang, C. Y. H.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006///
VL - 131
IS - 1
SP - 1
EP - 9
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Butrapet, S.: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20063041748. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Tropical Diseases; Public Health; Medical & Veterinary Entomology
N2 - The genetic stabilities of the three attenuation loci of the candidate dengue 2 (D2) PDK-53 vaccine virus were evaluated for the PDK-53 virus and PDK-53-vectored chimeric D2/1, D2/3, and D2/4 viruses following 10 sequential passages in Vero cells. Sequencing revealed that the dominant NS1-53-Asp and the NS3-250-Val attenuation loci were extremely stable, whereas reversion occurred at the 5′NCR-57-U locus in 10 of the 18 viral lineages tested. A more sensitive and quantitative assay, the TaqMan mismatch amplification mutation assay (TaqMAMA), was employed to more finely discriminate the level of reversion at the 5′NCR-57 locus. This rapid genetic assay permitted detection of ≤1% reversion of 5′NCR-57 U-to-C in viral populations. By TaqMAMA, various levels of reversion at 5′NCR-57 were detected in all 18 of the PDK-53-based viral lineages tested at Vero passage 10, but only 3 lineages had reversion levels >80% in the viral population. Chimeric viruses based on the PDK-53-V (all three mutations present) genetic background were more stable than those developed in the PDK-53-E (5′NCR and NS1 mutations present) background. The TaqMAMA can be applied in quality control analyses to ensure that attenuated vaccine seeds contain undetectable or minimal levels of reversion at a given attenuation locus.
KW - attenuation
KW - chimaeras
KW - complementary DNA
KW - DNA amplification
KW - genetic analysis
KW - genomes
KW - human diseases
KW - loci
KW - nucleotide sequences
KW - quantitative analysis
KW - rapid methods
KW - vaccines
KW - Dengue virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cDNA
KW - chimeras
KW - DNA sequences
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063041748&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: CHuang1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus bacteraemia: a case-control study.
AU - Carnicer-Pont, D.
AU - Bailey, K. A.
AU - Mason, B. W.
AU - Walker, A. M.
AU - Evans, M. R.
AU - Salmon, R. L.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2006///
VL - 134
IS - 6
SP - 1167
EP - 1173
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Carnicer-Pont, D.: National Public Health Service for Wales, Communicable Disease Surveillance Centre, Abton House, Cardiff CF14 3QX, UK.
N1 - Accession Number: 20063223612. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 61-32-5. Subject Subsets: Public Health
N2 - A case-control study was undertaken in an acute district general hospital to identify risk factors for hospital-acquired bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA). Cases of hospital-acquired MRSA bacteraemia were defined as consecutive patients from whom MRSA was isolated from a blood sample taken on the third or subsequent day after admission. Controls were randomly selected from patients admitted to the hospital over the same time period with a length of stay of more than 2 days who did not have bacteraemia. Data on 42 of the 46 cases of hospital-acquired bacteraemia and 90 of the 92 controls were available for analysis. There were no significant differences in the age or sex of cases and controls. After adjusting for confounding factors, insertion of a central line [adjusted odds ratio (aOR) 35.3, 95% confidence interval (CI) 3.8-325.5] or urinary catheter (aOR 37.1, 95% CI 7.1-193.2) during the admission, and surgical site infection (aOR 4.3, 95% CI 1.2-14.6) all remained independent risk factors for MRSA bacteraemia. The adjusted population attributable fraction, showed that 51% of hospital-acquired MRSA bacteraemia cases were attributable to a urinary catheter, 39% to a central line, and 16% to a surgical site infection. In the United Kingdom, measures to reduce the incidence of hospital-acquired MRSA bacteraemia in acute general hospitals should focus on improving infection control procedures for the insertion and, most importantly, care of central lines and urinary catheters.
KW - bacteraemia
KW - bacterial diseases
KW - catheters
KW - drug resistance
KW - human diseases
KW - methicillin
KW - nosocomial infections
KW - risk factors
KW - UK
KW - Wales
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacteremia
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - hospital infections
KW - surgical wound infection
KW - United Kingdom
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063223612&site=ehost-live&scope=site
UR - http://journals.cambridge.org/
UR - email: Brendan.mason@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Public health strategies to overcome barriers to optimal vitamin D status in populations with special needs.
AU - Calvo, M. S.
AU - Whiting, S. J.
A2 - Haas, J. H.
A2 - Miller, D. D.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006///
VL - 136
IS - 4
SP - 1135
EP - 1139
CY - Bethesda; USA
PB - American Society for Nutrition
SN - 0022-3166
AD - Calvo, M. S.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20063107490. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 33 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition
N2 - In North America, there is increasing public health awareness of the importance of adequate vitamin D intake to the maintenance of optimal vitamin D status and overall health. Experts now define this as circulating levels of 25-hydroxyvitamin D of 75-80 nmol/L. This serum level and high levels of dietary intake have been associated with significantly reduced risk of chronic diseases, such as osteoporosis, cardiovascular disease, diabetes, and some cancers. All of these diseases are more prevalent in the elderly of all races, and some are more prevalent and of greater severity among blacks than whites. Our objective is to review recent actions to increase public awareness of the health importance of maintaining optimal circulating 25(OH)D and potential strategies to increase vitamin D intake. Clinicians and educators are encouraged to promote improved vitamin D intake and status, particularly among the elderly and blacks. This will largely depend on combined efforts to judiciously fortify our food supply and to develop individual supplementation protocols for supplements or controlled use of UV light exposure to maintain optimal serum 25(OH)D, especially in high-risk groups. Growing evidence supports a low risk of toxicity with vitamin D use in fortification or supplementation, despite its past reputation of potential toxicity in excess. The cost to fortify food or supplements with vitamin D is relatively inexpensive compared with developing drugs used to treat or prevent chronic diseases; moreover, there is significant potential for broad health benefits in the reduced risk and prevention of multiple chronic diseases.
KW - cardiovascular diseases
KW - diabetes
KW - diet
KW - food supplements
KW - fortification
KW - human diseases
KW - nutrient intake
KW - osteoporosis
KW - public health
KW - vitamin D
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063107490&site=ehost-live&scope=site
UR - email: mona.calvo@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of the quantitative real-time polymerase chain reaction using a cDNA standard for human group A rotavirus.
AU - Min BokSoon
AU - Noh YoonJu
AU - Shin JinHo
AU - Baek SunYoung
AU - Min KyungIl
AU - Ryu SeungRel
AU - Kim ByoungGuk
AU - Park MiKyung
AU - Choi SeungEun
AU - Yang EunHee
AU - Park SueNie
AU - Hur SookJin
AU - Ahn ByungYoon
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006///
VL - 137
IS - 2
SP - 280
EP - 286
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Min BokSoon: Department of Biologics Evaluation, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20073036793. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - Nucleic acid amplification techniques are used frequently for rapid diagnosis of viral diseases. In this study, a real-time polymerase chain reaction protocol that uses primers specific for the viral VP4 gene and the commercial SYBR Green reagent were evaluated for the quantitative measurement of human rotavirus (HRV) RNA in human stool specimens. SYBR Green I detection involved analysis of the melting temperature of the PCR product and measurement of fluorescence at the optimum temperature. The assay resulted in a sensitive and reproducible detection of targets ranging from low (<102 rotavirus cDNA copies/reaction) to high numbers (>106 rotavirus cDNA copies/reaction). No cross-reaction was found with crude cell culture stocks of coxsackievirus, echovirus, poliovirus, hepatitis A virus and adenovirus. Analysis with the HRV cDNA standard demonstrated high reproducibility with a coefficient of variation (CV) of 0.2-0.9%. Daily performance among three different laboratories showed a CV no greater than 8%, indicating an intermediate level of variation. These results demonstrate the feasibility of this method for quantitative analysis of human rotavirus in clinical samples.
KW - complementary DNA
KW - diagnosis
KW - diagnostic techniques
KW - DNA amplification
KW - genes
KW - human diseases
KW - human faeces
KW - nucleic acids
KW - polymerase chain reaction
KW - Coxsackieviruses
KW - Hepatitis A virus
KW - human echoviruses
KW - man
KW - Poliovirus
KW - Rotavirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Hepatovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - cDNA
KW - Human echovirus
KW - human feces
KW - PCR
KW - Polioviruses
KW - real-time polymerase chain reaction
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073036793&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: ahnbyung@korea.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Increasing prevalences of overweight and obesity in northern plains American Indian children.
AU - Zephier, E.
AU - Himes, J. H.
AU - Story, M.
AU - Zhou, X.
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2006///
VL - 160
IS - 1
SP - 34
EP - 39
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Zephier, E.: Aberdeen Area Indian Health Service, Aberdeen, South Dakota, USA.
N1 - Accession Number: 20063036487. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - Objectives: To report prevalences of overweight and obesity in a large sample of American Indian children from a survey in 2002-2003, and to evaluate the change in prevalences since 1995-1996 when children on the same reservations were measured. Design: Analysis of survey data. Setting: Aberdeen Area Indian Health Service (North Dakota, South Dakota, Iowa, and Nebraska). Participants: A total of 11 538 American Indian children (aged 5-17 years) attending 55 schools on 12 reservations. Main Outcome Measure: Height and weight measured during the 2002-2003 school year by the same team as in the earlier survey. Prevalences of overweight (≥85th percentile) and obesity (≥95th percentile) were calculated on the basis of body mass index (calculated as weight in kilograms divided by the square of height in meters) and the Centers for Disease Control and Prevention growth charts. Results: At 5 years of age, 47% of boys and 41% of girls were overweight, and 24% of the children were obese. Prevalences of overweight and obesity exceeded those for the most recent available data for all US children at almost every age. In the intervening 7 to 8 years between surveys, prevalences of overweight and obesity continued to increase in the children by 4.5% and 4.3%, respectively. Conclusions: Prevalences of overweight and obesity in the most recent sample of American Indian children indicate that they are at even higher risk for these conditions and their health-related sequelae than the best estimates for all US children, with prevalences as high as or higher than those for any other racial or ethnic groups of children reported in the most recent national surveys.
KW - American indians
KW - boys
KW - children
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - girls
KW - obesity
KW - overweight
KW - school children
KW - Iowa
KW - Nebraska
KW - North Dakota
KW - South Dakota
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - Great Plains States of USA
KW - Northern Plains States of USA
KW - disease prevalance
KW - ethnic differences
KW - fatness
KW - school kids
KW - schoolchildren
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063036487&site=ehost-live&scope=site
UR - http://www.archpediatrics.com
UR - email: himes@epi.umn.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study.
AU - Hoppin, J. A.
AU - Umbach, D. M.
AU - London, S. J.
AU - Lynch, C. F.
AU - Alavanja, M. C. R.
AU - Sandler, D. P.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2006///
VL - 163
IS - 12
SP - 1129
EP - 1137
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Hoppin, J. A.: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709-2233, USA.
N1 - Accession Number: 20063130778. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 2921-88-2, 62-73-7, 944-22-9, 298-02-2, 13071-79-9, 99283-00-8. Subject Subsets: Medical & Veterinary Entomology; Weeds; Public Health
N2 - Pesticides are potential risk factors for respiratory disease among farmers, but farmers are also exposed to other respiratory toxicants. To explore the association of pesticides with wheeze in a population without other farming exposures, the authors analyzed data from 2,255 Iowa commercial pesticide applicators enrolled in the Agricultural Health Study. Controlling for age, smoking status, asthma and atopy history, and body mass index, the authors calculated odds ratios for the relationship between wheeze and 36 individual pesticides participants had used during the year before enrollment (1993-1997). Eight of 16 herbicides were associated with wheeze in single-agent models; however, the risk was almost exclusively associated with the herbicide chlorimuron-ethyl (odds ratio (OR)=1.62, 95% confidence interval (CI): 1.25, 2.10). Inclusion of chlorimuron-ethyl in models for the other herbicides virtually eliminated the associations. The odds ratios for four organophosphate insecticides (terbufos, fonofos, chlorpyrifos, and phorate) were elevated when these chemicals were modeled individually and remained elevated, though attenuated somewhat, when chlorimuron-ethyl was included. The association for dichlorvos, another organophosphate insecticide, was not attenuated by chlorimuron-ethyl (OR=2.48, 95% CI: 1.08, 5.66). Dose-response trends were observed for chlorimuron-ethyl, chlorpyrifos, and phorate; the strongest odds ratio was for applying chlorpyrifos on more than 40 days per year (OR=2.40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl.
KW - chlorimuron
KW - chlorpyrifos
KW - dichlorvos
KW - fonofos
KW - herbicides
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - organophosphate insecticides
KW - pesticides
KW - phorate
KW - respiratory diseases
KW - terbufos
KW - toxic substances
KW - wheezing
KW - Iowa
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - chlorpyrifos-ethyl
KW - DDVP
KW - lung diseases
KW - pesticide applicators
KW - poisons
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063130778&site=ehost-live&scope=site
UR - email: hoppin1@niehs.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Birth weight and mortality: causality or confounding?
AU - Basso, O.
AU - Wilcox, A. J.
AU - Weinberg, C. R.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2006///
VL - 164
IS - 4
SP - 303
EP - 311
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Basso, O.: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, MD A3-05, P.O. Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
N1 - Accession Number: 20063161787. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - The association between birth weight and mortality is among the strongest seen in epidemiology. While preterm delivery causes both small babies and high mortality, it does not explain this association. Fetal growth restriction has also been proposed, although its features are unclear because it lacks a definition independent of weight. If, as some postulate, birth weight is not itself on the causal path to mortality, its relation with mortality would have to be explained by confounding factors that decrease birth weight and increase mortality. In this paper, the authors explore the characteristics such confounders would require in order to achieve the observed association between birth weight and mortality. Through a simple simulation, they found that the observed steep gradient of risk for small babies at term can be produced by a rare condition or conditions (with a total prevalence of 0.5%) having profound effects on both fetal growth (-1.7 standard deviations) and mortality (relative risk=160). Candidate conditions might include malformations, fetal or placental aneuploidy, infections, or imprinting disorders. If such rare factors underlie the association of birth weight with mortality, it would have broad implications for the study of fetal growth restriction and birth weight, and for the prevention of infant mortality.
KW - birth weight
KW - epidemiology
KW - fetal growth
KW - infants
KW - mortality
KW - neonatal mortality
KW - premature infants
KW - prematurity
KW - risk
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - foetal growth
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063161787&site=ehost-live&scope=site
UR - http://aje.oxfordjournals.org/cgi/content/full/164/4/303
UR - email: bassoo2@niehs.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Peripheral insensate neuropathy - a tall problem for US adults?
AU - Cheng, Y. J.
AU - Gregg, E. W.
AU - Kahn, H. S.
AU - Williams, D. E.
AU - Rekeneire, N. de
AU - Narayan, K. M. V.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2006///
VL - 164
IS - 9
SP - 873
EP - 880
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Cheng, Y. J.: Information Technology Support Contract, Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, US Department of Health and Human Services, 4770 Buford Highway, N.E., Mailstop K-10, Atlanta, GA 30341, USA.
N1 - Accession Number: 20063215553. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - The relation between height and lower extremity peripheral insensate neuropathy among persons with and without diabetes was examined by use of the 1999-2002 US National Health and Nutrition Examination Survey with 5,229 subjects aged 40 or more years. A monofilament was used to determine whether any of three areas on each foot were insensate. Peripheral insensate neuropathy was defined as the presence of one or more insensate areas. Its prevalence was nearly twice as high among persons with diabetes (21.2%) as among those without diabetes (11.5%; p<0.001). Men (16.2%) had 1.7 times the prevalence of peripheral insensate neuropathy as did women (9.4%), but the difference was not significant after adjustment for height. Greater height was associated with increased peripheral insensate neuropathy prevalence among persons with and without diabetes (p<0.001). This association was characterized by a sharp increase in prevalence among persons who were taller than 175.5 cm. Peripheral insensate neuropathy risk was significantly higher among those taller than 175.5 cm (adjusted odds ratio=2.3, 95% confidence interval: 1.5, 3.5). The authors conclude that body height is an important correlate of peripheral insensate neuropathy. This association largely accounts for the difference in peripheral insensate neuropathy prevalence between men and women. Height may help health-care providers to identify persons at high risk of peripheral insensate neuropathy.
KW - adults
KW - body composition
KW - complications
KW - diabetes mellitus
KW - diabetic neuropathy
KW - height
KW - human diseases
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063215553&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: ycc1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production.
AU - Fang, H.
AU - Xu, L. X.
AU - Chen, T. Y.
AU - Cyr, J. M.
AU - Frucht, D. M.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2006///
VL - 176
IS - 10
SP - 6155
EP - 6161
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Fang, H.: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 29B, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063107391. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 308067-57-4.
N2 - Protective host immune responses to anthrax infection in humans and animal models are characterized by the development of neutralizing Abs against the receptor-binding anthrax protective Ag (PA), which, together with the lethal factor (LF) protease, composes anthrax lethal toxin (LT). We now report that B cells, in turn, are targets for LT. Anthrax PA directly binds primary B cells, resulting in the LF-dependent cleavage of the MAPK kinases (MAPKKs) and disrupted signaling to downstream MAPK targets. Although not directly lethal to B cells, anthrax LT treatment causes severe B cell dysfunction, greatly reducing proliferative responses to IL-4-, anti-IgM-, and/or anti-CD40 stimulation. Moreover, B cells treated with anthrax LT in vitro or isolated from mice treated with anthrax LT in vivo have a markedly diminished capacity to proliferate and produce IgM in response to TLR-2 and TLR-4 ligands. The suppressive effects of anthrax LT on B cell function occur at picomolar concentrations in vitro and at sublethal doses in vivo. These results indicate that anthrax LT directly inhibits the function of B cells in vitro and in vivo, revealing a potential mechanism through which the pathogen could bypass protective immune responses.
KW - animal models
KW - B lymphocytes
KW - bacterial toxins
KW - immune response
KW - immunity
KW - immunoglobulins
KW - in vitro
KW - laboratory animals
KW - neutralizing antibodies
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - B cells
KW - bacterium
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063107391&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: david.frucht@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature.
AU - Epstein, S. L.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006///
VL - 193
IS - 1
SP - 49
EP - 53
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Epstein, S. L.: Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-730, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20063023603. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.
KW - adults
KW - age differences
KW - children
KW - cross immunity
KW - human diseases
KW - influenza A
KW - viral diseases
KW - Ohio
KW - USA
KW - Influenzavirus A
KW - man
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - pandemics
KW - United States of America
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063023603&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/JID/
UR - email: epsteins@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - 1,25-Dihydroxyvitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice.
AU - Ivanov, A. P.
AU - Dragunsky, E. M.
AU - Chumakov, K. M.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006///
VL - 193
IS - 4
SP - 598
EP - 600
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Ivanov, A. P.: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20063090396. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 32222-06-3, 67-97-0, 308067-58-5. Subject Subsets: Human Nutrition
N2 - 1,25-Dihydroxyvitamin D3 (DHVD3) coadministered with monovalent inactivated poliovirus vaccine (IPV) of all 3 serotypes significantly enhances antipoliovirus systemic and mucosal immunity in mice. Although serum immunoglobulin G antibodies are significantly higher in serotypes 2 and 3, and although salivary immunoglobulin A is significantly increased in serotypes 1 and 3, DHVD3 had the most dramatic effect on the level of neutralizing serum antibodies of all 3 IPV serotypes. These findings suggest a possible use of vitamin D3 as an adjuvant for currently used and proposed new Sabin IPVs.
KW - animal models
KW - antibodies
KW - calcitriol
KW - cholecalciferol
KW - IgA
KW - IgG
KW - immune response
KW - immunization
KW - inactivated vaccines
KW - laboratory animals
KW - neutralizing antibodies
KW - saliva
KW - serotypes
KW - vaccination
KW - viral diseases
KW - Human poliovirus 1
KW - Human poliovirus 2
KW - Human poliovirus 3
KW - mice
KW - Poliovirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 1,25-dihydroxycholecalciferol
KW - 1,25-dihydroxyvitamin D
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - killed vaccines
KW - salivary secretions
KW - viral infections
KW - vitamin D3
KW - Host Resistance and Immunity (HH600)
KW - Animal Models of Human Nutrition (VV140)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063090396&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/JID/
UR - email: ivanov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of reversions in the 5′-untranslated region of attenuated poliovirus after sequential administration of inactivated and oral poliovirus vaccines.
AU - Laassri, M.
AU - Lottenbach, K.
AU - Belshe, R.
AU - Rennels, M.
AU - Plotkin, S.
AU - Chumakov, K.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006///
VL - 193
IS - 10
SP - 1344
EP - 1349
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Laassri, M.: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM-470, Rockville, MD 20852, USA.
N1 - Accession Number: 20063119278. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Replication of Sabin strains used in oral poliovirus vaccine (OPV) in the intestines of vaccine recipients leads to reversions that increase virus neurovirulence. Previously, a small study reported that prior immunization with inactivated poliovirus vaccine (IPV) resulted in faster accumulation of revertant virus, thus potentially increasing the risk of vaccine-associated paralytic poliomyelitis. We studied the impact that prior immunization with IPV and OPV has on shedding of revertant virus by healthy infants. By polymerase chain reaction (PCR), we amplified full-length poliovirus genomes directly from stool specimens from unimmunized infants and from infants previously immunized with IPV or OPV. The amplicons were used to quantify reversions in the 5′-untranslated region, using oligonucleotide microarray hybridization. Nearly all 140 samples that were PCR positive contained varying amounts of revertants of all 3 poliovirus serotypes. Polioviruses of Sabin types 2 and 3 reverted more easily than those of type 1. Prior vaccination with IPV did not increase the proportion of revertants after OPV administration.
KW - faeces
KW - human diseases
KW - immune response
KW - immunization
KW - infants
KW - paralysis
KW - polymerase chain reaction
KW - replication
KW - risk assessment
KW - vaccination
KW - virulence
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - feces
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - PCR
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063119278&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/JID/
UR - email: chumakov@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measles-virus-neutralizing antibodies in intravenous immunoglobulins.
AU - Audet, S.
AU - Virata-Theimer, M. L.
AU - Beeler, J. A.
AU - Scott, D. E.
AU - Frazier, D. J.
AU - Mikolajczyk, M. G.
AU - Eller, N.
AU - Chen, F. M.
AU - Yu, M. Y. W.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006///
VL - 194
IS - 6
SP - 781
EP - 789
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Audet, S.: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20063175007. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 308067-58-5, 308067-57-4. Subject Subsets: Public Health
N2 - Measles infection induces lifelong immunity; however, wild-type infection stimulates higher levels of measles-virus-neutralizing antibodies (mnAbs) than does vaccination. Because the proportion of the donor population with vaccine-induced measles immunity is increasing, this study was conducted to determine whether this shift in demographic characteristics affects mnAb levels in contemporary lots of Immune Globulin Intravenous (Human) (IGIV). When 166 lots of 7 IGIV products manufactured between 1998 and 2003 were assayed by plaque-reduction neutralization test, there was a progressive decrease in geometric mean titers in lots manufactured between 1999 and 2002. IGIV products manufactured from recovered plasma had significantly higher titers than did those manufactured from Source Plasma, which could reflect a change in donor demographic characteristics, because Source Plasma donors tend to be much younger. A reduction in mnAbs also correlated with the loss of either IgG1 and IgG3, possibly because of certain manufacturing procedures, or bivalent antibodies (i.e., intact IgG and F(ab′)2), because of fragmentation.
KW - blood plasma
KW - human diseases
KW - IgG
KW - immunoglobulins
KW - measles
KW - neutralizing antibodies
KW - USA
KW - man
KW - Measles virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - gamma-globulins
KW - immune globulins
KW - plasma (blood)
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063175007&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/JID/
UR - email: mei-ying.yu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Popcorn worker's lung: in vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine.
AU - Fedan, J. S.
AU - Dowdy, J. A.
AU - Fedan, K. B.
AU - Hubbs, A. F.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2006///
VL - 215
IS - 1
SP - 17
EP - 22
CY - Orlando; USA
PB - Elsevier Inc
SN - 0041-008X
AD - Fedan, J. S.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20063155032. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 431-03-8. Subject Subsets: Maize
N2 - Workers who inhale microwave popcorn butter flavorings experience decrements in lung function and can develop clinical bronchiolitis obliterans, i.e., "popcorn worker's lung" (Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E.J., Enright, P.L., 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347, 330-338.). In a rat inhalation model, vapors of an artificial butter flavoring damaged the epithelium of the upper and lower airways (Hubbs, A.F., Battelli, L.A., Goldsmith, W.T., Porter, D.W., Frazer, D., Friend, S., Schwegler-Berry, D., Mercer, R.R., Reynolds, J.S., Grote, A., Castranova, V., Kullman, G., Fedan, J.S., Dowdy, J., Jones, W.G., 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185, 128-135.). Diacetyl, a butter flavoring component, is a major volatile ketone in the popcorn-processing workplace. We investigated the effects of diacetyl on epithelium of guinea pig isolated airway preparations and the effects of diacetyl in vitro on reactivity to bronchoactive agents. In the isolated, perfused trachea preparation, diacetyl added to the intraluminal (mucosal) bath elicited responses that began with contraction (threshold ca. 3 mM) and ended with relaxation. After a 4-h incubation with intraluminal diacetyl (3 mM), contractions to extraluminal (serosal) methacholine (MCh) were slightly increased; however, sensitivity to intraluminally (mucosally) applied MCh was increased by 10-fold. Relaxation responses of MCh (3×10-7 M)-contracted tracheas to extraluminally applied terbutaline and intraluminally applied 120 mM KCl, to evoke epithelium-derived relaxing factor release, were unaffected by diacetyl. Exposure of the tracheal epithelium in Using chambers to diacetyl decreased transepithelial potential difference and resistance. These findings suggest that diacetyl exposure compromised epithelial barrier function, leading to hyperactivity to mucosally applied MCh. The respiratory epithelium appears to serve as an initial target for the toxic effects of diacetyl in the airways.
KW - animal models
KW - diacetyl
KW - factory workers
KW - flavour compounds
KW - food additives
KW - human diseases
KW - inhalation
KW - laboratory animals
KW - lungs
KW - maize
KW - occupational hazards
KW - popcorn
KW - respiratory diseases
KW - safety at work
KW - toxicity
KW - toxicology
KW - trachea
KW - guineapigs
KW - Zea mays
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - corn
KW - flavor compounds
KW - guinea pigs
KW - lung diseases
KW - methacholine
KW - occupational safety
KW - Crop Produce (QQ050)
KW - Food Additives (QQ130)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063155032&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4JHMRR4-3&_user=3891418&_handle=V-WA-A-W-AC-MsSAYWA-UUW-U-AAZAACCDVC-AACYDBZCVC-ABBCZDWBB-AC-U&_fmt=full&_coverDate=08%2F15%2F2006&_rdoc=4&_orig=browse&_srch=%23toc%237159%232006%23997849998%23628985!&_cdi=7159&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=e90605af42979e25517e54a81e4784ef
UR - email: jsf2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA perspectives on health claims for food labels.
AU - Rowlands, J. C.
AU - Hoadley, J. E.
A2 - Bagchi, D.
T3 - Specioal issue. Nutraceuticals and Functional Foods Regulations in the United States and Around The World
JO - Toxicology
JF - Toxicology
Y1 - 2006///
VL - 221
IS - 1
SP - 35
EP - 43
CY - Shannon; Irish Republic
PB - Elsevier Ireland
SN - 0300-483X
AD - Rowlands, J. C.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20063142061. Publication Type: Journal Article. Note: Specioal issue. Nutraceuticals and Functional Foods Regulations in the United States and Around The World Language: English. Number of References: 6 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - The U.S. Food and Drug Administration's regulatory authority over health claims was clarified in 1990 legislation known as the Nutrition Labeling and Education Act (NLEA). This law established mandatory nutrition labeling for most foods and placed restrictions on the use of food label claims characterizing the levels or health benefits of nutrients in foods. NLEA set a high threshold for the scientific standard under which the U.S. Food and Drug Administration (FDA) may authorize health claims, this standard is known as the significant scientific agreement (SSA) standard. Subsequent legislation known as the Food and Drug Administration Modernization Act (FDAMA) provided an alternative to FDA review of the health claim where an U.S. government scientific body other than FDA concluded that there is SSA for a substance/disease relationship. Courts have since extended the scope of health claims to include qualified health claims (QHC) that are health claims not substantiated on evidence that meets the level of SSA standard, but include a qualifying statement intended to convey to the consumer the level of evidence for the claim. FDA has responded by developing an evidence-based ranking system for scientific data to determine the level of evidence substantiating a health claim. The following is an overview of FDA's regulations and evidence-based method for evaluating health claims.
KW - consumer protection
KW - consumers
KW - functional foods
KW - labelling
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - labeling
KW - labels
KW - nutrition labelling
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063142061&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4J7B159-1&_user=3891418&_handle=V-WA-A-W-AZ-MsSAYVA-UUW-U-AAZDWYCBAA-AAZVYZZAAA-AUCDEDCAW-AZ-U&_fmt=full&_coverDate=04%2F03%2F2006&_rdoc=7&_orig=browse&_srch=%23toc%235175%232006%23997789998%23618031!&_cdi=5175&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=d71f27305893186e9fed829616fa73ff
UR - email: JCRowlands@Dow.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulations on health/functional foods in Korea.
AU - Kim JiYeon
AU - Kim DaiByung
AU - Lee HyongJoo
A2 - Bagchi, D.
T3 - Specioal issue. Nutraceuticals and Functional Foods Regulations in the United States and Around The World
JO - Toxicology
JF - Toxicology
Y1 - 2006///
VL - 221
IS - 1
SP - 112
EP - 118
CY - Shannon; Irish Republic
PB - Elsevier Ireland
SN - 0300-483X
AD - Kim JiYeon: Nutrition and Functional Food Headquarters, Korea Food and Drug Administration, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20063142057. Publication Type: Journal Article. Note: Specioal issue. Nutraceuticals and Functional Foods Regulations in the United States and Around The World Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The term "health/functional food" (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these products to be marketed in measured doses, such as in pills, tablets, capsules, and liquids. HFFs are of two types: generic and product-specific. There are 37 ingredients listed in the act for generic HFFs, and if an HFF contains a new active ingredient that is not included in the generic 37 products, it is considered a product-specific HFF. The standardization, safety, and efficacy of a new active ingredient are reviewed by the Korean Food and Drug Administration in order to receive approval as a product-specific HFF. Conforming with international standards and protecting public health requires constant upgrading of the Health/Functional Food Act.
KW - chemical composition
KW - food legislation
KW - food safety
KW - food supplements
KW - functional foods
KW - regulations
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - rules
KW - South Korea
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063142057&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4J8D974-2&_user=3891418&_handle=V-WA-A-W-AZ-MsSAYVA-UUW-U-AAZDWYCBAA-AAZVYZZAAA-AUCDEDCAW-AZ-U&_fmt=full&_coverDate=04%2F03%2F2006&_rdoc=14&_orig=browse&_srch=%23toc%235175%232006%23997789998%23618031!&_cdi=5175&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=694157b15fe651b7ae36055f10cd4710
UR - email: leehyjo@snu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
AU - Xia, Q. S.
AU - Chou, M. W.
AU - Edgar, J. A.
AU - Doerge, D. R.
AU - Fu, P. P.
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2006///
VL - 231
IS - 1
SP - 138
EP - 145
CY - Oxford; UK
PB - Elsevier
SN - 0304-3835
AD - Xia, Q. S.: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063171008. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 303-34-4. Subject Subsets: Weeds
N2 - Pyrrolizidine alkaloids (PAs) are probably the most common poisonous compounds affecting livestock, wildlife, and humans. The PAs that have been found to be tumorigenic in experimental animals belong to the retronecine-, heliotridine-, and otonecine-type PAs. Our recent mechanistic studies indicated that riddelliine, a tumorigenic retronecine-type PA, induced tumors via a genotoxic mechanism mediated by the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. The same adducts were formed from clivorine, a tumorigenic otonecine-type PA from metabolism of clivorine by rat liver microsomes in the presence of calf thymus DNA. In this study, we report that metabolism of lasiocarpine, the prototype heliotridine PA, by F344 rat liver microsomes resulted in the formation of DHP. When incubated in the presence of calf thymus DNA, the same DHP-derived DNA adducts were formed. These results suggest that these DHP-derived DNA adducts are potential biomarkers of exposure and tumorigenicity for all types of PAs.
KW - animal models
KW - exposure
KW - laboratory animals
KW - lasiocarpine
KW - pyrrolizidine alkaloids
KW - toxic substances
KW - clivorine
KW - poisons
KW - riddelliine
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063171008&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-4FPYWW1-3&_user=3891418&_handle=V-WA-A-W-AE-MsSAYWA-UUA-U-AAZUYWWBZU-AACYVUBAZU-AWZDWUCCZ-AE-U&_fmt=full&_coverDate=01%2F08%2F2006&_rdoc=17&_orig=browse&_srch=%23toc%234992%232006%23997689998%23613399!&_cdi=4992&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=ccd65cce3d1462e85c82626ae1683941
UR - email: pfu@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.
AU - Ding, M.
AU - Feng, R. T.
AU - Wang, S. Y.
AU - Bowman, L.
AU - Lu, Y. J.
AU - Qian, Y.
AU - Castranova, V.
AU - Jiang, B. H.
AU - Shi, X. L.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006///
VL - 281
IS - 25
SP - 17359
EP - 17368
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Ding, M.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063123467. Publication Type: Journal Article. Language: English. Number of References: 54 ref. Registry Number: 528-58-5, 308079-78-9. Subject Subsets: Aromatic & Medicinal Plants
N2 - Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced .OH and O2. radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumours per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-κB and AP-1 and expression of cyclooxygenase-2 and tumour necrosis factor-α. These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumour xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumour cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumour promoter-induced carcinogenesis and tumour metastasis in vivo.
KW - anticarcinogenic properties
KW - blackberries
KW - cell lines
KW - cyanidin
KW - cytotoxic compounds
KW - cytotoxicity
KW - enzyme activity
KW - enzymes
KW - free radicals
KW - gene expression
KW - glucosides
KW - lungs
KW - medicinal plants
KW - natural products
KW - neoplasms
KW - skin
KW - transactivation
KW - tumour necrosis factor
KW - man
KW - mice
KW - Rubus fruticosus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Rubus
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - anti-carcinogenic properties
KW - brambles
KW - cachectin
KW - cachexin
KW - cancers
KW - dermis
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - transcriptional activation
KW - tumor necrosis factor
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063123467&site=ehost-live&scope=site
UR - email: mid5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The development of species-specific immunodiagnostics for Stachybotrys chartarum: the role of cross-reactivity.
AU - Schmechel, D.
AU - Simpson, J. P.
AU - Beezhold, D.
AU - Lewis, D. M.
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2006///
VL - 309
IS - 1/2
SP - 150
EP - 159
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0022-1759
AD - Schmechel, D.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 1095 Willowdale Road, M/S L-4020, Morgantown, WV 26505, USA.
N1 - Accession Number: 20063052434. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Mycology; Public Health
N2 - Mold contamination and exposure to fungi in indoor environments has been associated with various adverse health effects but little is known about the significance of individual fungal species in the initiation or exacerbation of such effects. Using Stachybotrys chartarum as a model fungus we sought to demonstrate that monoclonal antibodies (mAbs) can provide species-specific diagnostic reagents and also be used to investigate immunological cross-reactivity patterns among fungi. Mice were immunized with S. chartarum spore walls and monoclonal antibodies were screened against 60 fungal species and 24 different isolates of S. chartarum using an indirect ELISA. One species-specific mAb (IgG1) reacted only with spore preparations but not mycelium of S. chartarum or propagules of any other fungus. Five cross-reactive mAbs (IgM) documented extensive cross-reactivity among nine related Stachybotrys species and several non-related genera including several species of Cladosporium, Memnoniella, Myrothecium and Trichoderma. We also found that the ELISA reactivity for cross-reactive antigens and different isolates of S. chartarum differed considerably for normalized total amounts of mycelial antigen. We demonstrate that mAbs and immunoassays have the potential to detect S. chartarum species-specifically. The observed reactivity patterns with cross-reactive mAbs suggest that several fungi may share common antigens and that the majority of antigens are expressed by spores and mycelia. The observed cross-reactivity patterns need to be considered for accurate interpretations of environmental and serological analyses.
KW - cross reaction
KW - ELISA
KW - human diseases
KW - immunodiagnosis
KW - monoclonal antibodies
KW - fungi
KW - man
KW - mice
KW - Stachybotrys
KW - Stachybotrys chartarum
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Muridae
KW - rodents
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - Stachybotrys
KW - enzyme linked immunosorbent assay
KW - fungus
KW - Hyphomycetes
KW - serological diagnosis
KW - Stachybotrys atra
KW - Animal Immunology (LL650) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Diagnosis of Animal Diseases (LL886) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063052434&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0022-1759
UR - email: dschmechel@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein.
AU - Gemeniano, M.
AU - Mpanju, O.
AU - Salomon, D. R.
AU - Eiden, M. V.
AU - Wilson, C. A.
JO - Virology
JF - Virology
Y1 - 2006///
VL - 346
IS - 1
SP - 108
EP - 117
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Gemeniano, M.: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, HFM-725, Building 29B, Room 2NN12, Bethesda, MD 20892, USA.
N1 - Accession Number: 20063178777. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science; Pig Science
N2 - Endogenous retroviral genetic material serves as a reservoir for the generation of retroviral pathogens by recombination between activated endogenous or exogenous infectious agents. Some porcine tissues actively express infectious porcine endogenous retroviruses (PERVs). Of the three classes of PERV characterized to date, two, PERV-A and B, are capable of infecting human cells in vitro, whereas PERV-C cannot. Here, we demonstrate that the PERV-C envelope surface protein (SU) when disassociated from its C-terminus binds human cells. Further, we show that PERV-C binding to human cells is not inhibited in 293 cells productively infected with PERV-A, confirming that the molecule PERV-C interacts with on human cells is distinct from that used by PERV-A. Moreover, we demonstrate that the envelope region encompassing the proline-rich region is required for binding to cells in addition to the putative variable region A (VRA) and B (VRB). The region in the C-terminus of the SU that alters the binding and infectivity properties of PERV-C differs by only nine residues from the analogous region of PERV-A. Caution may be warranted even when a xenotransplantation product is from source pigs that do not express human-tropic viruses, as minimal mutations within PERV-C combined with selection in a human recipient could render PERV-C infectious in humans.
KW - disease transmission
KW - host range
KW - infectivity
KW - surface proteins
KW - zoonoses
KW - man
KW - pigs
KW - Retroviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - hogs
KW - membrane proteins
KW - Porcine retrovirus
KW - swine
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063178777&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXR-4HMNFVS-1&_user=3891418&_handle=V-WA-A-W-WB-MsSAYZW-UUW-U-AAZVVAEZZZ-AAZWUUUVZZ-WBUVADAZE-WB-U&_fmt=full&_coverDate=03%2F01%2F2006&_rdoc=12&_orig=browse&_srch=%23toc%237165%232006%23996539998%23617135!&_cdi=7165&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=176e796f21d8111945c45a51f61663de
UR - email: wilsonc@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Streamlined sample preparation procedure for determination of perchlorate anion in foods by ion chromatography-tandem mass spectrometry.
AU - Krynitsky, A. J.
AU - Niemann, R. A.
AU - Williams, A. D.
AU - Hopper, M. L.
A2 - Dasgupta, P. K.
T3 - Special isssue: Perchlorate: an Enigma for the New Millennium.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2006///
VL - 567
IS - 1
SP - 94
EP - 99
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Krynitsky, A. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073201766. Publication Type: Journal Article. Note: Special isssue: Perchlorate: an Enigma for the New Millennium. Language: English. Subject Subsets: Animal Nutrition; Horticultural Science; Postharvest Research; World Agriculture, Economics & Rural Sociology; Human Nutrition; Maize; Wheat, Barley & Triticale Abstracts
N2 - A rapid, sensitive, and specific method was developed for the determination of perchlorate anion in foods. The foods included high moisture fruits and vegetables, low moisture foods (e.g. wheat flour and corn meal), and infant foods. Improvements to existing procedures were made in sample preparation that reduced sample test portion size from 100 to 5 or 10 g, extraction solvent volume from 150 to 20-40 ml, and replaced blending extraction-vacuum filtration and their associated large glassware with a simple shakeout-centrifugation in a small conical tube. Procedures common to all matrices involved: extraction, centrifugation, graphitized carbon solid phase extraction (SPE) cleanup, and ion chromatography-tandem mass spectrometry (IC-MS/MS) analysis. A Waters IC-Pak Anion HR column (4.6 mm × 75 mm) was eluted with 100 mM ammonium acetate in 50:50 (v/v) acetonitrile/water mobile phase at a rate of 0.35 ml/min. A triple stage quadrupole mass spectrometer, equipped with electrospray ionization (ESI) in the negative ion mode, was used to detect perchlorate anion. An 18O4-labeled perchlorate anion internal standard was used to correct for any matrix effects. The method limit of quantitation (LOQ) was: 1.0 µg/kg in fruits, vegetables, and infant foods; 3.0 µg/kg in dry products. Fortified test portions gave 80-120% recoveries. Determination of incurred perchlorate anion residues agreed well with results for comparable commodities or products analysed by published methods.
KW - analysis
KW - blending
KW - centrifuges
KW - commodities
KW - determination
KW - equipment
KW - estimation
KW - flours
KW - foods
KW - fruits
KW - infant foods
KW - maize meal
KW - mass spectrometry
KW - meal
KW - residues
KW - separators
KW - techniques
KW - vegetables
KW - wheat
KW - wheat flour
KW - Triticum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - baby foods
KW - vegetable crops
KW - Food Science and Food Products (Human) (QQ000)
KW - Forage and Feed Products (Non-human) (RR000)
KW - Horticultural Economics (EE111) (New March 2000)
KW - Crop Produce (QQ050)
KW - Human Nutrition (General) (VV100)
KW - Techniques and Methodology (ZZ900)
KW - Field Crops (FF005) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073201766&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4J84SWJ-2&_user=10&_coverDate=05%2F10%2F2006&_rdoc=16&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235216%232006%23994329998%23622626%23FLA%23display%23Volume)&_cdi=5216&_sort=d&_docanchor=&view=c&_ct=23&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a97edcbd4f219e34c0d9c92cbc8085e1
UR - email: Alex.Krynitsky@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.
AU - Mei, N.
AU - Arlt, V. M.
AU - Phillips, D. H.
AU - Heflich, R. H.
AU - Chen, T.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2006///
VL - 602
IS - 1/2
SP - 83
EP - 91
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0027-5107
AD - Mei, N.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063225292. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Registry Number: 9007-49-2. Subject Subsets: Aromatic & Medicinal Plants
N2 - Aristolochic acid (AA) is a potent nephrotoxin and carcinogen and is the causative factor for Chinese herb nephropathy. AA has been associated with the development of urothelial cancer in humans, and kidney and forestomach tumors in rodents. To investigate the molecular mechanisms responsible for the tumorigenicity of AA, we determined the DNA adduct formation and mutagenicity of AA in the liver (nontarget tissue) and kidney (target tissue) of Big Blue rats. Groups of six male rats were gavaged with 0, 0.1, 1.0 and 10.0 mg AA/kg body weight five times/week for 3 months. The rats were sacrificed 1 day after the final treatment, and the livers and kidneys were isolated. DNA adduct formation was analyzed by 32P-postlabeling and mutant frequency (MF) was determined using the λ Select-cII Mutation Detection System. Three major adducts (7-[deoxyadenosin-N6-yl]-aristolactam I, 7-[deoxyadenosin-N6-yl]-aristolactam II and 7-[deoxyguanosin-N2-yl]-aristolactam I) were identified. There were strong linear dose-responses for AA-induced DNA adducts in treated rats, ranging from 25 to 1967 adducts/108 nucleotides in liver and 95-4598 adducts/108 nucleotides in kidney. A similar trend of dose-responses for mutation induction also was found, the MFs ranging from 37 to 666×10-6 in liver compared with the MFs of 78-1319×10-6 that we previously reported for the kidneys of AA-treated rats. Overall, kidneys had at least two-fold higher levels of DNA adducts and MF than livers. Sequence analysis of the cII mutants revealed that there was a statistically significant difference between the mutation spectra in both kidney and liver of AA-treated and control rats, but there was no significant difference between the mutation spectra in AA-treated livers and kidneys. A:T -> T:A transversion was the predominant mutation in AA-treated rats; whereas G:C -> A:T transition was the main type of mutation in control rats. These results indicate that the AA treatment that eventually results in kidney tumors in rats also results in significant increases in DNA adduct formation and cII MF in kidney. Although the same treatment does not produce tumors in rat liver, it does induce DNA adducts and mutations in this tissue, albeit at lower levels than in kidney.
KW - DNA
KW - dosage effects
KW - induced mutations
KW - kidney diseases
KW - kidneys
KW - liver
KW - medicinal plants
KW - mutagenicity
KW - mutants
KW - nucleotide sequences
KW - nucleotides
KW - traditional medicines
KW - Aristolochia
KW - rats
KW - Aristolochiaceae
KW - Aristolochiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - deoxyribonucleic acid
KW - DNA sequences
KW - drug plants
KW - kidney disorders
KW - medicinal herbs
KW - nephropathy
KW - officinal plants
KW - renal diseases
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063225292&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00275107
UR - email: nan.mei@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane.
AU - Toraason, M.
AU - Lynch, D. W.
AU - DeBord, D. G.
AU - Singh, N.
AU - Krieg, E.
AU - Butler, M. A.
AU - Toennis, C. A.
AU - Nemhauser, J. B.
JO - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research, Genetic Toxicology and Environmental Mutagenesis
Y1 - 2006///
VL - 603
IS - 1
SP - 1
EP - 14
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1383-5718
AD - Toraason, M.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20063078835. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - 1-Bromopropane (1-BP; n-propyl bromide) (CAS No. 106-94-5) is an alternative to ozone-depleting chlorofluorocarbons that has a variety of potential applications as a decreasing agent for metals and electronics, and as a solvent vehicle for spray adhesives. Its isomer, 2-brompropane (2-BP; isopropyl bromide) (CAS No. 75-26-3) impairs antioxidant cellular defenses, enhances lipid peroxidation, and causes DNA damage in vitro. The present study had two aims. The first was to assess DNA damage in human leukocytes exposed in vitro to 1- or 2-BP. DNA damage was also assessed in peripheral leukocytes from workers with occupational exposure to 1-BP. In the latter assessment, start-of- and end-of-work week blood and urine samples were collected from 41 and 22 workers at two facilities where 1-BP was used as a solvent for spray adhesives in foam cushion fabrication. Exposure to 1-BP was assessed from personal-breathing zone samples collected for 1-3 days up to 8 h per day for calculation of 8 h time weighted average (TWA) 1-BP concentrations. Bromide (Br) was measured in blood and urine as a biomarker of exposure. Overall, 1-BP TWA concentrations ranged from 0.2 to 271 parts per million (ppm) at facility A, and from 4 to 27 ppm at facility B. The highest exposures were to workers classified as sprayers. 1-BP TWA concentrations were statistically significantly correlated with blood and urine Br concentrations. The comet assay was used to estimate DNA damage. In vitro, 1- or 2-BP induced a statistically significant increase in DNA damage at 1 mM. In 1-BP exposed workers, start-of- and end-of-workweek comet endpoints were stratified based on job classification. There were no significant differences in DNA damage in leukocytes between workers classified as sprayers (high 1-BP exposure) and those classified as non-sprayers (low 1-BP exposure). At the facility with the high exposures, comparison of end-of-week values with start-of-week values using paired analysis revealed non-sprayers had significantly increased comet tail moments, and sprayers had significantly increased comet tail moment dispersion coefficients. A multivariate analysis included combining the data sets from both facilities, log transformation of 1-BP exposure indices, and the use of multiple linear regression models for each combination of DNA damage and exposure indices including exposure quartiles. The covariates were gender, age, smoking status, facility, and glutathione S-transferase M1 and T1 (GSTM1, GSTT1) polymorphisms. In the regression models, start-of-week comet tail moment in leukocytes was significantly associated with serum Br quartiles. End-of-week comet tail moment was significantly associated with 1-BP TWA quartiles, and serum Br quartiles. Gender, facility, and GSTM1 had a significant effect in one or more models. Additional associations were not identified from assessment of dispersion coefficients. In vitro and in vivo results provide limited evidence that 1-BP exposure may pose a small risk for increasing DNA damage.
KW - blood
KW - DNA
KW - exposure
KW - genotoxicity
KW - human diseases
KW - in vitro
KW - industrial workers
KW - leukocytes
KW - occupational hazards
KW - occupational health
KW - urine
KW - North Carolina
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - 1-bromopropane
KW - deoxyribonucleic acid
KW - DNA damage
KW - leucocytes
KW - United States of America
KW - white blood cells
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063078835&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/13835718
UR - email: mtoraason@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Proceedings of the Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB and Substituted Amphetamines, held in Isola di San Servolo, Venice, Italy, 16-19 August 2005.
AU - Ali, S. F.
AU - Fornai, F.
A2 - Ali, S. F.
A2 - Fornai, F.
T2 - Annals of the New York Academy of Sciences
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006///
VL - 1074
SP - xvi + 676
EP - xvi + 676
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0077-8923
AD - Ali, S. F.: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073104312. Publication Type: Journal issue; Conference proceedings. Language: English. Registry Number: 300-62-9, 561-27-3, 302-31-8, 57-27-2, 64-31-3, 54-11-5. Subject Subsets: Public Health
N2 - This journal issue is divided into 10 parts discussing different aspects of drug abuse and neurotoxicity. Topics include: genes and drug abuse; methamphetamine neurotoxicity; oxidative stress, neurodegeneration and neuroprotection; similarities and differences between methamphetamine and 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP); methylenedioxymethamphetamine (MDMA) and other substituted amfetamines; cocaine; heroin, morphine and opiates; nicotine and marijuana; γ-hydroxybutyrate; and perinatal and postnatal outcomes of cocaine and substituted amphetamine abuse.
KW - amfetamine
KW - cannabis resin
KW - drug abuse
KW - genes
KW - genetic factors
KW - heroin
KW - human diseases
KW - morphine
KW - neurotoxicity
KW - nicotine
KW - opiates
KW - oxidative stress
KW - pregnancy
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - amphetamine
KW - diacetylmorphine
KW - diamorphine
KW - drug use
KW - gamma-hydroxybutyrate
KW - gestation
KW - methamphetamine
KW - Human Reproduction and Development (VV060)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073104312&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/nyas
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential health effects of occupational chlorinated solvent exposure.
AU - Ruder, A. M.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006///
VL - 1076
SP - 207
EP - 227
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0077-8923
AD - Ruder, A. M.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073094404. Publication Type: Journal Article. Language: English. Number of References: 118 ref. Registry Number: 71-43-2, 67-66-3, 74-84-0, 74-82-8, 75-09-2, 127-18-4, 79-01-6. Subject Subsets: Public Health
N2 - Based on toxicology, metabolism, animal studies, and human studies, occupational exposure to chlorinated aliphatic solvents (methanes, ethanes, and ethenes) has been associated with numerous adverse health effects, including central nervous system, reproductive, liver, and kidney toxicity, and carcinogenicity. However, many of these solvents remain in active, large-volume use. This article reviews the recent occupational epidemiology literature on the most widely used solvents, methylene chloride, chloroform, trichloroethylene, and tetrachloroethylene, and discusses other chlorinated aliphatics. The impact of studies to date has been lessened because of small study size, inability to control for confounding factors, particularly smoking and mixed occupational exposures, and the lack of evidence for a solid pathway from occupational exposure to biological evidence of exposure, to precursors of health effects, and to health effects. International differences in exposure limits may provide a "natural experiment" in the coming years if countries that have lowered exposure limits subsequently experience decreased adverse health effects among exposed workers. Such decreases could provide some evidence that higher levels of adverse health effects were associated with higher levels of solvent exposure. The definitive studies, which should be prospective biomarker studies incorporating body burden of solvents as well as markers of effect, remain to be done.
KW - benzene
KW - chlorinated hydrocarbons
KW - chloroform
KW - epidemiology
KW - ethane
KW - exposure
KW - human diseases
KW - leukaemia
KW - methane
KW - methylene chloride
KW - morbidity
KW - mortality
KW - neoplasms
KW - reviews
KW - solvents
KW - tetrachloroethylene
KW - trichloroethylene
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood cancer
KW - cancers
KW - death rate
KW - dichloromethane
KW - leucaemia
KW - leukemia
KW - occupational hazard
KW - perchloroethylene
KW - tetrachloroethene
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073094404&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/nyas
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis.
AU - Delmonte, P.
AU - Perry, J.
AU - Rader, J. I.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2006///
VL - 1107
IS - 1/2
SP - 59
EP - 69
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Delmonte, P.: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration (CFSAN-FDA), 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20063050282. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 486-66-8, 485-72-3, 446-72-0. Subject Subsets: Soyabeans; Aromatic & Medicinal Plants
N2 - Isoflavones are phytochemicals found in many plants. Because of their structural similarity to β-estradiol, health benefits of isoflavones have been evaluated in age-related and hormone-dependent diseases. Dietary supplement preparations contain extracts from soy, Red Clover and kudzu. Soy products contain primarily genistein, daidzein, and glycitein, while Red Clover products contain primarily formononetin and biochanin A. Kudzu extracts contain puerarin and daidzein among other components. Previous methods of analysis focused on the determination of isoflavones from a single botanical source, while dietary supplements are often a blend of extracts from different plants. We developed a method for the analysis of isoflavones in dietary supplements regardless of their botanical composition, using HPLC-PDA because of its applicability to routine analysis. Isoflavones are found as free compounds, glucoside derivatives, 6″-O-malonyl-β-D-glucoside and 6″-O-acetyl-β-D-glucoside derivatives. In this study, the samples were extracted at room temperature with 50:50 (v/v) MeCN/water, and then analyzed before and after hydrolyzing the isoflavones by acid or basic digestion. 2′-Methoxy-flavone and 6-methoxy-flavone were used as internal standards and were added together to every sample. Daidzein, glycitein, genistein, puerarin, calycosin, pratensein, pseudobaptigenin, formononetin, biochanin A and prunetin were among the isoflavones determined.
KW - analytical methods
KW - daidzein
KW - food supplements
KW - formononetin
KW - genistein
KW - hydrolysis
KW - isoflavones
KW - soyabeans
KW - Glycine (Fabaceae)
KW - Pueraria montana
KW - Pueraria montana var. lobata
KW - Pueraria thunbergiana
KW - Trifolium pratense
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Pueraria
KW - Trifolium
KW - Pueraria montana
KW - analytical techniques
KW - biochanin A
KW - calycosin
KW - glycitein
KW - prunetin
KW - puerarin
KW - soybeans
KW - Food Chemistry (QQ600) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063050282&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4J2KXVK-2&_user=3891418&_handle=V-WA-A-W-VA-MsSAYWA-UUA-U-AAVDYZCAUE-AAVCVVCEUE-YUBEEZZCD-VA-U&_fmt=full&_coverDate=02%2F24%2F2006&_rdoc=10&_orig=browse&_srch=%23toc%235248%232006%23988929998%23616073!&_cdi=5248&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=2c9023e5db66a89aeac84f2c6239cefc
UR - email: pierluigi.delmonte@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of liquid chromatography-mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a "natural" herbal dietary supplement.
AU - Reepmeyer, J. C.
AU - Woodruff, J. T.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2006///
VL - 1125
IS - 1
SP - 67
EP - 75
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Reepmeyer, J. C.: US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA.
N1 - Accession Number: 20063176406. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition; Aromatic & Medicinal Plants
N2 - An herbal dietary supplement, marketed as a natural product for the enhancement of sexual function, was purchased covertly over the internet. The product was analyzed by LC-MS and found to contain a compound related to synthetic phosphodiesterase 5 (PDE-5) inhibitors. Based on LC with photodiode array and mass spectral detection, along with collision-induced dissociation-mass spectral analysis, the structure of the compound was tentatively identified as a designer drug of vardenafil in which the N-ethylpiperazine ring had been replaced by a piperidine ring. This structure was unambiguously confirmed by acid hydrolysis of both the unknown ("piperidenafil") and vardenafil and comparison of their hydrolysis products by LC-MS and GC-MS. The hydrolytic technique proved to be a useful tool for the structure elucidation of piperidenafil and may be a useful technique for the structure elucidation of other erectile dysfunction designer drugs in the future. The dosage level of piperidenafil in the herbal product was 41 mg per capsule when calculated as the free base.
KW - analytical methods
KW - detection
KW - enzyme inhibitors
KW - food supplements
KW - herbal drugs
KW - liquid chromatography
KW - mass spectrometry
KW - natural products
KW - analytical techniques
KW - herbal medicines
KW - phosphodiesterase 5 inhibitors
KW - piperidenafil
KW - vardenafil
KW - Crop Produce (QQ050)
KW - Human Nutrition (General) (VV100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063176406&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4K428NY-3&_user=3891418&_handle=V-WA-A-W-AD-MsSAYVW-UUA-U-AAZBCDZDCE-AAZAACDCCE-WUWVVBBAU-AD-U&_fmt=full&_coverDate=08%2F25%2F2006&_rdoc=6&_orig=browse&_srch=%23toc%235248%232006%23988749998%23629228!&_cdi=5248&view=c&_acct=C000028398&_version=1&_urlVersion=0&_userid=3891418&md5=d0286ffc7f1a393bd4f153e0d77db31e
UR - email: reepmeyerj@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of mycotoxins in botanical roots.
AU - Trucksess, M. W.
AU - Weaver, C.
AU - Oles, C.
AU - D'Ovidio, K.
AU - Rader, J. I.
A2 - Khan, I . A.
A2 - Smillie, T. J.
A2 - Craker, L. E.
A2 - Gardner, Z. E.
JO - Acta Horticulturae
JF - Acta Horticulturae
Y1 - 2006///
IS - 720
SP - 103
EP - 112
CY - Leuven; Belgium
PB - International Society for Horticultural Science (ISHS)
SN - 0567-7572
SN - 9066056290
AD - Trucksess, M. W.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073106526. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 13 ref. Subject Subsets: Plant Pathology; Ornamnental Horticulture; Horticultural Science; Postharvest Research; Aromatic & Medicinal Plants
N2 - Mycotoxins are toxic secondary metabolites produced by certain molds and are common contaminants of many important food crops, such as grains, nuts, and spices. Some mycotoxins are found in fruits, vegetables, and botanical roots. These contaminants have a broad range of toxic effects, including carcinogenicity, immunotoxicity, neurotoxicity, and reproductive and developmental toxicity. The public health concerns related to both acute and chronic effects of mycotoxins in animals have prompted more than 100 countries to establish regulatory limits for some of the well-known mycotoxins such as the aflatoxins (AFL). Our research focused on method development for two of these toxins: AFL and ochratoxin A (OTA) in botanical roots, specifically in ginseng and other selected roots. Methods using an immunoaffinity column (IAC) cleanup, liquid chromatographic separation, and fluorescence detection were modified and evaluated. Two types of IAC were evaluated: IAC for AFL and IAC for both AFL and OTA. Three derivatization techniques to enhance the fluorescence of the AFL were compared: pre-column trifluoroacetic acid, post-column bromination and post-column UV irradiation. No derivatization was needed for OTA. Results for AFL using the single analyte IAC and the three derivatization techniques were all comparable for ginseng and for other roots such as ginger, licorice, and kava-kava. Recoveries of added AFL for ginseng at levels from 2 ng/g to 16 ng/g were about 80%. Recoveries of added AFL for ginger, licorice and kava-kava were about 60%. Recoveries of added AFL for ginseng at 4-16 ng/g using IAC for both AFL and OTA were about 70%. Recoveries of added OTA for ginseng, ginger, and echinacea at 4 ng/g were about 55%.
KW - aflatoxins
KW - analytical methods
KW - contaminants
KW - fluorescence
KW - ginger
KW - irradiation
KW - liquid chromatography
KW - liquorice
KW - medicinal plants
KW - mycotoxins
KW - ochratoxins
KW - roots
KW - secondary metabolites
KW - techniques
KW - ultraviolet radiation
KW - Pennsylvania
KW - USA
KW - Wisconsin
KW - Echinacea purpurea
KW - Glycyrrhiza
KW - Glycyrrhiza glabra
KW - Panax quinquefolius
KW - Piper methysticum
KW - Zingiber
KW - Zingiber officinale
KW - Echinacea
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Glycyrrhiza
KW - Panax
KW - Araliaceae
KW - Apiales
KW - Piper
KW - Piperaceae
KW - Piperales
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - Zingiber
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - North Central States of USA
KW - Lake States of USA
KW - analytical techniques
KW - Araliales
KW - drug plants
KW - fungal toxins
KW - licorice
KW - medicinal herbs
KW - officinal plants
KW - United States of America
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Storage Problems and Pests of Non-food/Non-feed Plant Products (SS210)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073106526&site=ehost-live&scope=site
UR - http://www.actahort.org
UR - email: mtruckse@cfsan.fda.gov\jeanne.rader@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticides in botanical dietary supplements.
AU - Wong, J. W.
AU - Wirtz, M. S.
AU - Hennessy, M. K.
AU - Schenck, F. J.
AU - Krynitsky, A. J.
AU - Capar, S. G.
A2 - Khan, I . A.
A2 - Smillie, T. J.
A2 - Craker, L. E.
A2 - Gardner, Z. E.
JO - Acta Horticulturae
JF - Acta Horticulturae
Y1 - 2006///
IS - 720
SP - 113
EP - 128
CY - Leuven; Belgium
PB - International Society for Horticultural Science (ISHS)
SN - 0567-7572
SN - 9066056290
AD - Wong, J. W.: Center for Food Safety and Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-336, College Park, MD 20740, USA.
N1 - Accession Number: 20073106527. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 31 ref. Registry Number: 82-68-8. Subject Subsets: Horticultural Science; Postharvest Research; Aromatic & Medicinal Plants; Agricultural Entomology
N2 - Current U.S. Food and Drug Administration (FDA) procedures to analyze pesticides in botanical dietary supplements are described. The procedures are from FDA protocols for pesticide analysis in foods, which involve organic solvent extraction (usually with acetone:water or acetonitrile:water) of the sample, followed by cleanup to remove interfering coextractives, and subsequent analysis primarily by gas chromatography-mass spectrometry. In samples collected in 2004, pesticides were found in 44 out of 87 samples of botanical dietary supplements (the majority of these being ginseng products) suspected of containing pesticides. Over 30 different types of organochlorine, organophosphorus, and organonitrogen pesticide residues were present in these samples, with pentachloroaniline, pentachlorobenzene, and quintozene being the most abundant. A majority of these products contained more than one pesticide; one such sample was found to contain as many as 12 organochlorine compounds. Concentrations of pesticide residues ranged from 0.001 (pentachloroaniline and pentachlorophenyl methyl ester) to 5.57 mg/kg (quintozene). The presence and concentration of pesticides found in dietary supplements indicate the need for increased monitoring. However, current and new procedures need to be validated for pesticides in botanical dietary supplements and expanded to include other pesticide classes.
KW - analytical methods
KW - food contamination
KW - food supplements
KW - GC-MS
KW - herbal drugs
KW - medicinal plants
KW - monitoring
KW - organochlorine compounds
KW - organochlorine pesticides
KW - organophosphorus pesticides
KW - pesticide residues
KW - pesticides
KW - quintozene
KW - solvents
KW - Panax
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - Araliales
KW - drug plants
KW - food contaminants
KW - gas chromatography-mass spectrometry
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - organic chlorine compounds
KW - organic chlorine pesticides
KW - PCNB
KW - pentachloronitrobenzene
KW - surveillance systems
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073106527&site=ehost-live&scope=site
UR - http://www.actahort.org
UR - email: jon.wong@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety evaluation of botanicals as new drugs: a report from CDER botanical team.
AU - Chen, S. T.
A2 - Khan, I . A.
A2 - Smillie, T. J.
A2 - Craker, L. E.
A2 - Gardner, Z. E.
JO - Acta Horticulturae
JF - Acta Horticulturae
Y1 - 2006///
IS - 720
SP - 181
EP - 184
CY - Leuven; Belgium
PB - International Society for Horticultural Science (ISHS)
SN - 0567-7572
SN - 9066056290
AD - Chen, S. T.: Office of Drug Evaluation I, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Building 22, Room 4134, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20073106533. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Horticultural Science; Aromatic & Medicinal Plants
N2 - This presentation will summarize the experience of safety evaluation for botanical products to be used as drugs, from the perspective of U.S. Food and Drug Administration (FDA). The current regulatory environment will be reviewed first, with a report on the status of botanical drug applications in FDA's Center for Drug Evaluation and Research (CDER). Regulatory experience and related issues in the safety reviews of botanical applications will then follow. More emphasis will be placed on the safety assessment of botanical INDs (Investigational New Drug application); basic principles in safety review of botanical NDAs (New Drug Application for marketing approval) will also be discussed.
KW - herbal drugs
KW - medicinal plants
KW - regulations
KW - safety
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - rules
KW - Laws and Regulations (DD500)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073106533&site=ehost-live&scope=site
UR - http://www.actahort.org
UR - email: chens@cder.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation of frying fat and oil.
AU - Firestone, D.
A2 - Erickson, M. D.
T2 - Deep frying: chemistry, nutrition, and practical applications
Y1 - 2006///
IS - Ed.2
CY - Urbana; USA
PB - AOCS Press
SN - 9781893997929\1893997928
AD - Firestone, D.: Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20103264663. Publication Type: Book chapter. Language: English. Number of References: 13 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - Recently there has been increased recognition that improper use of frying fats degrades the fat and reduces the quality of fried food. However, formal laws and regulations for control of frying fat and fried food quality have been adopted by only a few countries while several others employ practical recommendations and test procedures. This chapter presents the regulations and guidelines issued and implemented by various countries, including the USA, Australia, Austria, Belgium, Czech Republic, France, Germany, Hungary, Iceland, Israel, Italy, Japan, Luxembourg, the Netherlands, Portugal, Scandinavian countries (Norway, Sweden, Finland), Spain, and Switzerland, regarding quality of frying fat/oil and fried foods.
KW - consumer protection
KW - cooking fats
KW - cooking oils
KW - food legislation
KW - food quality
KW - food safety
KW - fried foods
KW - guidelines
KW - law
KW - regulations
KW - Australia
KW - Austria
KW - Belgium
KW - Czech Republic
KW - Finland
KW - France
KW - Germany
KW - Hungary
KW - Iceland
KW - Israel
KW - Italy
KW - Japan
KW - Luxembourg
KW - Netherlands
KW - Norway
KW - Portugal
KW - Spain
KW - Sweden
KW - Switzerland
KW - USA
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Central Europe
KW - Europe
KW - European Union Countries
KW - Benelux
KW - Western Europe
KW - Scandinavia
KW - Northern Europe
KW - Mediterranean Region
KW - EFTA
KW - Middle East
KW - West Asia
KW - Asia
KW - Southern Europe
KW - East Asia
KW - Kingdom of the Netherlands
KW - North America
KW - America
KW - consumer advocacy
KW - legal aspects
KW - legal principles
KW - recommendations
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Consumer Economics (EE720)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103264663&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - New developments in silver ion and reverse phase HPLC of conjugated linoleic acid.
AU - Delmonte, P.
AU - Kramer, J. K. G.
AU - Banni, S.
AU - Yurawecz, M. P.
A2 - Yurawecz, M. P.
A2 - Kramer, J. K. G.
A2 - Gudmundsen, O.
A2 - Pariza, M. W.
A2 - Banni, S.
T2 - Advances in conjugated linoleic acid research, Volume 3
Y1 - 2006///
CY - Urbana; USA
PB - AOCS Press
SN - 9781893997875
AD - Delmonte, P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20103307809. Publication Type: Book chapter. Language: English. Number of References: 43 ref. Registry Number: 60-33-3, 14701-21-4. Subject Subsets: Human Nutrition
N2 - This chapter presents improved separations of the conjugated linoleic acid (CLA) isomers using modified silver ion and reverse phase high performance liquid chromatography techniques (Ag+-HPLC and RP-HPLC, respectively), primarily covering the chromatographic separation of CLA as fatty acid methyl esters. Several direct ways to obtain small quantities of new reference materials from commonly available reagents are described. The use of different elution systems and the effect of column temperature on the Ag+-HPLC of CLA are discussed.
KW - analytical methods
KW - fatty acid esters
KW - HPLC
KW - isomers
KW - linoleic acid
KW - reference standards
KW - separation
KW - silver ions
KW - temperature
KW - analytical techniques
KW - conjugated linoleic acids
KW - high performance liquid chromatography
KW - separating
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103307809&site=ehost-live&scope=site
UR - email: yurawecz@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antioxidative activity of conjugated linoleic acid determined by ESR.
AU - Yin, J. J.
AU - Yu, L. P.
AU - Yurawecz, M. P.
AU - Roach, J. A. G.
AU - Mossoba, M. M.
AU - Yu, L. L.
AU - Kramere, J. K. G.
A2 - Yurawecz, M. P.
A2 - Kramer, J. K. G.
A2 - Gudmundsen, O.
A2 - Pariza, M. W.
A2 - Banni, S.
T2 - Advances in conjugated linoleic acid research, Volume 3
Y1 - 2006///
CY - Urbana; USA
PB - AOCS Press
SN - 9781893997875
AD - Yin, J. J.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20103307815. Publication Type: Book chapter. Language: English. Number of References: 20 ref. Registry Number: 60-33-3. Subject Subsets: Human Nutrition
N2 - This chapter explores the potential role of conjugated linoleic acid (CLA) in cellular membranes by comparing the antioxidant properties of CLA isomers in liposomes using the electron spin resonance technique (ESR). The effects of phosphatidylcholines (PC) containing CLA in liposomes are described. The properties in liposomes for different PC incorporating CLA are compared. The effects of testing systems on fatty acid reactions with DPPH radical, the influence of fatty acid composition on the phase transition temperature of phospholipid bilayer system, and the ESR determination of lipid peroxidation in different lipid systems containing different fatty acids are discussed.
KW - analytical methods
KW - antioxidant properties
KW - cell membranes
KW - fatty acids
KW - free radicals
KW - isomers
KW - linoleic acid
KW - lipid peroxidation
KW - liposomes
KW - phosphatidylcholines
KW - phospholipids
KW - spectroscopy
KW - temperature
KW - analytical techniques
KW - anti-oxidant properties
KW - conjugated linoleic acids
KW - electron spin resonance spectroscopy
KW - lecithins
KW - radical scavenging properties
KW - Physiology of Human Nutrition (VV120)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103307815&site=ehost-live&scope=site
UR - email: yurawecz@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Advances in conjugated linoleic acid research, Volume 3.
AU - Yurawecz, M. P.
AU - Kramer, J. K. G.
AU - Gudmundsen, O.
AU - Pariza, M. W.
AU - Banni, S.
A2 - Yurawecz, M. P.
A2 - Kramer, J. K. G.
A2 - Gudmundsen, O.
A2 - Pariza, M. W.
A2 - Banni, S.
T2 - Advances in conjugated linoleic acid research, Volume 3
Y1 - 2006///
CY - Urbana; USA
PB - AOCS Press
SN - 9781893997875
AD - Yurawecz, M. P.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20103307810. Publication Type: Book. Language: English. Number of References: many ref. Registry Number: 60-33-3, 14701-21-4. Subject Subsets: Dairy Science
N2 - This volume provides a comprehensive coverage of the chemistry and biological properties of conjugated linoleic acid (CLA). It includes 14 chapters organized into 4 parts: biosynthesis and metabolic processes; techniques of determination of individual CLA isomers; diversity of CLA; and effects of CLA isomers in humans. Part 1 provides a summary of the biosynthesis of CLA within the gut microbial ecosystem of ruminants (Chapter 1) and describes the metabolic processes of CLA in animal and human tissues (Chapter 2). Part 2 discusses the chemical syntheses of CLA (Chapter 3), techniques for the systematic analysis of CLA isomers in the milk and meat of ruminants (Chapter 4), new developments in silver ion and reverse phase high performance liquid chromatography of CLA (Chapter 5), and structural characterization of CLA methyl esters using acetonitrile chemical ionization tandem mass spectrometry (Chapter 6). Part 3 describes the growth inhibition and apoptotic cell death of cancer cells induced by CLA (Chapter 7), modulatory properties of CLA on inflammation and immune function (Chapter 8), hypotensive properties of CLA (Chapter 9), and antioxidative activity of CLA determined by electron spin resonance technique (Chapter 10). Lastly, Part 4 reviews the effects of CLA on body weight and body composition in humans (Chapter 11), lipid class distribution and subcellular distribution of CLA in healthy and cancerous human tissues (Chapter 12), lipid-lowering actions of trans-10, cis-12 CLA in primary cultures of human (pre)adipocytes (Chapter 13), and safety data on CLA from animal studies, including CLA toxicity and effects of CLA on body composition, diabetes, cancer, cardiovascular disease, inflammation, gestation and lactation (Chapter 14).
KW - adipocytes
KW - analytical methods
KW - animal models
KW - anticarcinogenic properties
KW - antihypertensive properties
KW - antioxidant properties
KW - apoptosis
KW - biosynthesis
KW - body composition
KW - body weight
KW - cardiovascular diseases
KW - cell cultures
KW - cytotoxicity
KW - diabetes
KW - fatty acid esters
KW - food safety
KW - HPLC
KW - human diseases
KW - hypertension
KW - hypolipaemic properties
KW - immune system
KW - immunomodulatory properties
KW - in vitro
KW - inflammation
KW - isomers
KW - laboratory animals
KW - lactation
KW - linoleic acid
KW - lipids
KW - mass spectrometry
KW - meat
KW - metabolism
KW - milk
KW - neoplasms
KW - pregnancy
KW - rumen microorganisms
KW - silver ions
KW - spectroscopy
KW - structure
KW - synthesis
KW - techniques
KW - tissues
KW - toxicity
KW - man
KW - ruminants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Artiodactyla
KW - acetonitrile chemical ionization tandem mass spectrometry
KW - analytical techniques
KW - anti-carcinogenic properties
KW - anti-hypertensive properties
KW - anti-oxidant properties
KW - cancers
KW - conjugated linoleic acids
KW - electron spin resonance spectroscopy
KW - fat cells
KW - gestation
KW - high blood pressure
KW - high performance liquid chromatography
KW - hypolipemic properties
KW - hypolipidaemic properties
KW - hypolipidemic properties
KW - lipins
KW - radical scavenging properties
KW - rumen micro-organisms
KW - Animal Nutrition (Physiology) (LL510)
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Food Chemistry (QQ600) (New June 2002)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103307810&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Beta-lactam resistance in enterococci.
AU - Rafii, F.
A2 - Kobayashi, N.
T2 - Drug resistance of enterococci: epidemiology and molecular mechanisms
Y1 - 2006///
CY - Trivandrum; India
PB - Research Signpost
SN - 8177362909
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20063212059. Publication Type: Book chapter. Language: English. Number of References: 70 ref. Registry Number: 9001-74-5. Subject Subsets: Public Health
N2 - To help in the understanding of the mechanisms of β-lactam resistance in enterococci, this chapter examines the molecular genetic basis of β-lactamase production in these bacteria (particularly, Enterococcus faecalis/faecium). Genes that regulate the production of β-lactamases are identified. The occurrence of gene transfer between Staphylococcus and Enterococcus strains, and the role of transposons in the dissemination of β-lactamase in enterococci are discussed. The role of penicillin-binding proteins (PBPs) in intrinsic and acquired β-lactam resistance in enterococci, and the genetic factors that regulate its activity are highlighted.
KW - antibacterial agents
KW - antibiotics
KW - beta-lactam antibiotics
KW - beta-lactamase
KW - binding proteins
KW - drug resistance
KW - enzyme activity
KW - gene expression
KW - gene transfer
KW - genes
KW - genetic regulation
KW - molecular genetics
KW - resistance mechanisms
KW - reviews
KW - transposable elements
KW - Enterococcus
KW - Enterococcus faecalis
KW - Enterococcus faecium
KW - Staphylococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Enterococcus
KW - Staphylococcaceae
KW - Bacillales
KW - bacterium
KW - biochemical genetics
KW - carrier proteins
KW - DNA insertion elements
KW - insertion elements
KW - insertion sequences
KW - mobile genetic elements
KW - mobile sequences
KW - penicillin
KW - penicillinase
KW - transposons
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063212059&site=ehost-live&scope=site
UR - email: frafii@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Bioinformatics for predicting allergenicity.
AU - Gendel, S. M.
A2 - Maleki, S. J.
A2 - Burks, A. W.
A2 - Helm, R. M.
T2 - Food allergy
Y1 - 2006///
CY - Washington; USA
PB - ASM Press
SN - 9781555813758
AD - Gendel, S. M.: Food and Drug Administration, 6502 S. Archer Rd., Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20063178806. Publication Type: Book chapter. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Agricultural Biotechnology
N2 - This chapter describes the online allergen sequence databases and related analytical resources that are important for the assessment of the potential allergenicity of genetically modified foods. The extent of the diversity among allergen-related bioinformatic resources is illustrated. It is suggested that this diversity provides descriptive information that could lead to principles of good database practices.
KW - allergens
KW - amino acid sequences
KW - analytical methods
KW - assessment
KW - bioinformatics
KW - databases
KW - genetically engineered foods
KW - on line
KW - analytical techniques
KW - data banks
KW - genetically modified food
KW - genetically modified foods
KW - GM foods
KW - protein sequences
KW - Information and Documentation (CC300)
KW - Food Composition and Quality (QQ500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063178806&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Approaches to the detection of food allergens, from a food science perspective.
AU - Westphal, C. D.
A2 - Maleki, S. J.
A2 - Burks, A. W.
A2 - Helm, R. M.
T2 - Food allergy
Y1 - 2006///
CY - Washington; USA
PB - ASM Press
SN - 9781555813758
AD - Westphal, C. D.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20063178803. Publication Type: Book chapter. Language: English. Number of References: many ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition; Agricultural Engineering
N2 - This chapter provides an overview of the current trends in food allergen detection and the factors and steps involved in the analysis. Special attention is given on commercially available kits (e.g., immunoassays, biosensors). Future approaches, such as the applicability of DNA-based analytical techniques (e.g., polymerase chain reaction), automation of analytical procedures, and confirmatory methods are discussed.
KW - allergens
KW - analytical methods
KW - automation
KW - biosensors
KW - confirmatory tests
KW - detection
KW - DNA
KW - foods
KW - immunoassay
KW - polymerase chain reaction
KW - analytical techniques
KW - deoxyribonucleic acid
KW - PCR
KW - Automation and Control (NN050)
KW - Food Composition and Quality (QQ500)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Biosensors and Biological Nanotechnology (WW900) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063178803&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Pathogenic mechanisms of foodborne viral disease.
AU - Goswami, B. B.
AU - Kulka, M.
A2 - Potter, M.
T2 - Food consumption and disease risk: consumer-pathogen interactions
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2006///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 1845690125\9781845690120
AD - Goswami, B. B.: Division of Molecular Biology, HFS-025, Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083133391. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Number of References: 345 ref. Subject Subsets: Public Health
N2 - This chapter discusses the factors contributing to the pathogenicity of viral foodborne diseases, including nature of the viruses, viral genomes and genes, viral capsid and routes of viral entry. The mechanisms of host cell invasion, host defences and virus-induced host cell damage are described. The implications for foodborne disease treatment (e.g., antiviral therapy) and prevention (e.g., vaccination) are discussed.
KW - antiviral agents
KW - cell invasion
KW - coat proteins
KW - defence mechanisms
KW - disease prevention
KW - drug therapy
KW - foodborne diseases
KW - genes
KW - genomes
KW - human diseases
KW - immune response
KW - immunity
KW - immunization
KW - pathogenesis
KW - pathogenicity
KW - vaccination
KW - viral diseases
KW - man
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - capsid proteins
KW - chemotherapy
KW - defense mechanisms
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083133391&site=ehost-live&scope=site
UR - email: biswendu.goswami@fda.hhs.gov\michael.kulka@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Food consumption and disease risk: consumer-pathogen interactions.
AU - Potter, M.
A2 - Potter, M.
T2 - Food consumption and disease risk: consumer-pathogen interactions
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2006///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 1845690125\9781845690120
AD - Potter, M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W. Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083133396. Publication Type: Book. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Subject Subsets: Human Nutrition; Public Health; Helminthology; World Agriculture, Economics & Rural Sociology
N2 - This book reviews vital issues in the relationship between consumers and foodborne bacteria, viruses and parasites, and surveys how interactions between microorganisms and their human hosts influence foodborne diseases. It includes 17 chapters divided into 3 parts. Part I (7 chapters) considers factors that increase the risk of exposure to foodborne hazards, exploring issues such as the changing population demographics and trends in agricultural management. Part II (3 chapters) examines human host factors that influence foodborne diseases. It includes chapters on nonspecific host defences, immunity to foodborne pathogens and heightened susceptibility to foodborne disease due to underlying illness or pregnancy. Part III (7 chapters) reviews the mechanisms used by numerous pathogenic agents to invade, evade, colonize and reproduce in the human host. It also covers quantitative microbiological risk assessment essential for the protection of public health. This book will be an essential reference for microbiologists, research and development, and quality assurance staff in the food industry.
KW - agriculture
KW - bacterial diseases
KW - demography
KW - farm management
KW - food consumption
KW - food contamination
KW - foodborne diseases
KW - foods
KW - human diseases
KW - illness
KW - immunity
KW - microbial contamination
KW - parasites
KW - parasitoses
KW - pathogens
KW - pregnancy
KW - public health
KW - risk
KW - risk assessment
KW - susceptibility
KW - viral diseases
KW - bacteria
KW - man
KW - viruses
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - gestation
KW - parasitic diseases
KW - parasitic infestations
KW - parasitosis
KW - viral infections
KW - Agricultural Economics (EE110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083133396&site=ehost-live&scope=site
UR - email: Morris.Potter@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Patulin.
AU - Jackson, L.
AU - Dombrink-Kurtzman, M. A.
A2 - Sapers, G. M.
A2 - Gorny, J. R.
A2 - Yousef, A. E.
T2 - Microbiology of fruits and vegetables
Y1 - 2006///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849322618
AD - Jackson, L.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Bedford, Illinois, USA.
N1 - Accession Number: 20053178417. Publication Type: Book chapter. Language: English. Number of References: 168 ref. Registry Number: 149-29-1. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - This chapter reviews the literature on the chemical properties of patulin, methods for monitoring the occurrence and levels of patulin in food, regulation of patulin levels, factors affecting growth of Penicillium expansum and patulin formation, and methods for controlling the levels of this toxin in apple products.
KW - analytical methods
KW - apples
KW - chemical properties
KW - food contamination
KW - food safety
KW - growth
KW - methodology
KW - mycotoxins
KW - patulin
KW - regulations
KW - Malus
KW - Penicillium expansum
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Penicillium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - analytical techniques
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - Hyphomycetes
KW - methods
KW - rules
KW - Laws and Regulations (DD500)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053178417&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Microbiological safety of fresh citrus and apple juices.
AU - Keller, S. E.
AU - Miller, A. J.
A2 - Sapers, G. M.
A2 - Gorny, J. R.
A2 - Yousef, A. E.
T2 - Microbiology of fruits and vegetables
Y1 - 2006///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849322618
AD - Keller, S. E.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, Summit Argo, Illinois, USA.
N1 - Accession Number: 20053178413. Publication Type: Book chapter. Language: English. Number of References: 96 ref. Subject Subsets: Horticultural Science; Public Health; Aromatic & Medicinal Plants
N2 - This chapter briefly describes the production of citrus and apple juices, their physical characteristics, and typical microflora. Emphasis is given on pathogens that have been associated with fresh juice and on recent regulations related to the prevention of foodborne illness outbreaks. Contamination sources and intervention methods are also discussed.
KW - apple juice
KW - apples
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - fruit juices
KW - human diseases
KW - microbial contamination
KW - pathogens
KW - regulations
KW - Citrus
KW - Malus
KW - Malus pumila
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - Malus
KW - food contaminants
KW - rules
KW - Rutales
KW - Laws and Regulations (DD500)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053178413&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Effect of quality sorting and culling on the microbiological quality of fresh produce.
AU - Keller, S. E.
A2 - Sapers, G. M.
A2 - Gorny, J. R.
A2 - Yousef, A. E.
T2 - Microbiology of fruits and vegetables
Y1 - 2006///
CY - Boca Raton; USA
PB - CRC Press Inc.
SN - 0849322618
AD - Keller, S. E.: National Center for Food Safety and Technology, U.S. Food and Drug Administration, Summit Argo, Illinois, USA.
N1 - Accession Number: 20053178422. Publication Type: Book chapter. Language: English. Number of References: 27 ref. Subject Subsets: Horticultural Science; Plant Pathology; Aromatic & Medicinal Plants; Postharvest Research
N2 - This chapter focuses on the effects of grading and sorting methods as well as good agricultural practices on the microbiological quality of fresh and fresh cut fruits and vegetables. The impact of quality sorting and culling on food safety, particularly the risk of pathogen infiltration into fresh produce, is also discussed.
KW - crop quality
KW - food contamination
KW - food safety
KW - fruits
KW - grading
KW - microbial contamination
KW - minimal processing
KW - pathogen elimination
KW - risk
KW - sorting
KW - vegetables
KW - food contaminants
KW - vegetable crops
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20053178422&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Colistin.
AU - Friedlander, L. G.
AU - Arnold, D.
T2 - Residue evaluation of certain veterinary drugs. 66th meeting of joint FAO/WHO expert committee on food additives, Rome, Italy, 22-28 February 2006
T3 - FAO JECFA Monographs 2
Y1 - 2006///
CY - Rome; Italy
PB - Food and Agriculture Organization of the United Nations (FAO)
SN - 925105553X
AD - Friedlander, L. G.: Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20063236400. Publication Type: Book chapter; Conference paper. Note: FAO JECFA Monographs 2 Language: English. Number of References: many ref. Subject Subsets: Pig Science; Dairy Science; Poultry; Veterinary Science
KW - analytical methods
KW - animal tissues
KW - body fat
KW - chemistry
KW - chromatography
KW - dosage
KW - drug excretion
KW - drug formulations
KW - drug metabolism
KW - drug residues
KW - eggs
KW - ewe milk
KW - food
KW - kidneys
KW - liver
KW - milk
KW - muscles
KW - pharmacokinetics
KW - poultry
KW - skin
KW - tissue distribution
KW - veterinary products
KW - cattle
KW - fowls
KW - pigs
KW - sheep
KW - turkeys
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - Meleagris
KW - analytical techniques
KW - animal health products
KW - chickens
KW - colistin
KW - dermis
KW - domesticated birds
KW - hogs
KW - sheep milk
KW - swine
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20063236400&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bioaerosol sampling for the detection of aerosolized influenza virus.
AU - Blachere, F. M.
AU - Lindsley, W. G.
AU - Slaven, J. E.
AU - Green, B. J.
AU - Anderson, S. E.
AU - Chen, B. T.
AU - Beezhold, D. H.
JO - Influenza and other Respiratory Viruses
JF - Influenza and other Respiratory Viruses
Y1 - 2007///
VL - 1
IS - 3
SP - 113
EP - 120
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1750-2640
AD - Blachere, F. M.: Centers for Disease Control, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073283777. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - Background: Influenza virus was used to characterize the efficacy of a cyclone-based, two-stage personal bioaerosol sampler for the collection and size fractionation of aerosolized viral particles. Methods: A Collison single-jet nebulizer was used to aerosolize the attenuated FluMist® vaccine into a calm-air settling chamber. Viral particles were captured with bioaerosol samplers that utilize 2 microcentrifuge tubes to collect airborne particulates. The first tube (T1) collects particles greater than 1.8 µm in diameter, while the second tube (T2) collects particles between 1.0 and 1.8 µm, and the back-up filter (F) collects submicron particles. Following aerosolization, quantitative PCR was used to detect and quantify H1N1 and H3N2 influenza strains. Results: Based on qPCR results, we demonstrate that aerosolized viral particles were efficiently collected and separated according to aerodynamic size using the two-stage bioaerosol sampler. Most viral particles were collected in T2 (1-1.8 µm) and on the back-up filter (< 1 µm) of the bioaerosol sampler. Furthermore, we found that the detection of viral particles with the two-stage sampler was directly proportional to the collection time. Consequently, viral particle counts were significantly greater at 40 minutes in comparison to 5, 10 and 20 minute aerosol collection points. Conclusions: Due to a lack of empirical data, aerosol transmission of influenza is often questioned. Using FluMist®, we demonstrated that a newly developed bioaerosol sampler is able to recover and size fractionate aerosolized viral particles. This sampler should be an important tool for studying viral transmission in clinical settings and may significantly contribute towards understanding the modes of influenza virus transmission.
KW - aerosol sprayers
KW - aerosols
KW - drug delivery systems
KW - human diseases
KW - immunization
KW - influenza
KW - influenza viruses
KW - methodology
KW - sampling
KW - vaccination
KW - vaccines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - administration routes
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - methods
KW - sampling techniques
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073283777&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/irv
UR - email: fblachere@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The US National Antimicrobial Resistance Monitoring System.
AU - Gilbert, J. M.
AU - White, D. G.
AU - McDermott, P. F.
JO - Future Microbiology
JF - Future Microbiology
Y1 - 2007///
VL - 2
IS - 5
SP - 493
EP - 500
CY - London; UK
PB - Future Medicine Ltd
SN - 1746-0913
AD - Gilbert, J. M.: Center for Veterinary Medicine, US FDA, Office of New Animal Drug Evaluation, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20073284200. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Veterinary Science; Veterinary Science
N2 - The use of antimicrobial agents in food animals can select for resistant bacterial pathogens that may be transmitted to humans via the commercial meat supply. In the USA, the FDA's Center for Veterinary Medicine regulatory duties require a determination that antimicrobial drugs are safe and effective for use in food animals. In addition, a qualitative assessment of risks to human health from antimicrobial resistance requires development. This risk assessment process is supported by data generated by the FDA's National Antimicrobial Resistance Monitoring System (NARMS) for enteric bacteria. NARMS data on antimicrobial susceptibility among Salmonella, Campylobacter, Escherichia coli and Enterococcus is collected. Research activities defining the genetic bases of resistance helps to understand the potential public health risks posed by the spread of antimicrobial resistance from food animal antimicrobial use. These activities help insure that antimicrobials are used judiciously to promote human and animal health.
KW - animal health
KW - antibacterial agents
KW - bacterial diseases
KW - disease transmission
KW - drug resistance
KW - drug susceptibility
KW - food contamination
KW - human diseases
KW - risk assessment
KW - USA
KW - Campylobacter
KW - Enterococcus
KW - Escherichia coli
KW - man
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - food contaminants
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073284200&site=ehost-live&scope=site
UR - http://www.futuremedicine.com/doi/abs/10.2217/17460913.2.5.493
UR - email: jeff.gilbert@fda.hhs.gov\david.white@fda.hhs.gov\patrick.mcdermott@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Medical toxicology and public health - update on research and activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry.
AU - Schier, J. G.
AU - Algren, A.
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
Y1 - 2007///
VL - 3
IS - 2
SP - 85
EP - 85
CY - Philadelphia; USA
PB - University of Pennsylvania Press
AD - Schier, J. G.: U.S. Public Health Service, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20093097007. Publication Type: Journal Article. Language: English. Registry Number: 437-38-7. Subject Subsets: Tropical Diseases
N2 - The following is an update on research and activities in which medical toxicologists are actively involved at the National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry at the Centers for Disease Control and Prevention. An outbreak of acute renal failure with neurological symptoms in Panama and an outbreak of fentanyl-related deaths are reported.
KW - adverse effects
KW - fentanyl
KW - human diseases
KW - kidney diseases
KW - mortality
KW - nervous system diseases
KW - outbreaks
KW - renal failure
KW - Panama
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - Threshold Countries
KW - adverse reactions
KW - death rate
KW - kidney disorders
KW - kidney failure
KW - nephropathy
KW - neuropathy
KW - renal diseases
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093097007&site=ehost-live&scope=site
UR - http://jmt.pennpress.org/strands/jmt/pdfHandler.pdf;jsessionid=45E8853CF3E6DE014142744283A1B505?issue=20070302&file=20070302_085.pdf
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The epidemic of extreme obesity among American Indian and Alaska Native adults with diabetes.
AU - Wilson, C.
AU - Gilliland, S.
AU - Moore, K.
AU - Acton, K.
JO - Preventing Chronic Disease
JF - Preventing Chronic Disease
Y1 - 2007///
VL - 4
IS - 1
SP - 1
EP - 8
CY - Washington; USA
PB - National Center for Chronic Disease Prevention and Health Promotion
SN - 1545-1151
AD - Wilson, C.: Indian Health Service, Phoenix Indian Medical Center, 4212 N 16th Street, Phoenix, AZ 85016, USA.
N1 - Accession Number: 20073035132. Publication Type: Journal Article. Language: English. Language of Summary: Chinese; Spanish; French. Number of References: 30 ref. Subject Subsets: Human Nutrition
N2 - Introduction: The purpose of this study was to describe the prevalence of obesity among American Indian and Alaska Native (AI/AN) adults with diabetes and to examine the temporal trends for class I, II, and III obesity in this high-risk group during a 10-year period. Methods: We used data on body mass index (BMI) from the annual Diabetes Care and Outcomes Audit to estimate the prevalence of class I, II, and III obesity (class I=30.0-34.9 kg/m2, class II=35.0-39.9 kg/m2, and class III ≥40.0 kg/m2) in each year from 1995 through 2004. We also investigated trends in mean BMI during the 10-year period and the role of treatment in these trends using multivariable linear regression models. Results: Obesity was highly prevalent in this population in 2004 (class I, 28.9%; class II, 20.4%; class III, 20.3%). From 1995 through 2004, the percentage of obese adults increased from 16.7% to 20.4% in class II and 11.5% to 20.3% in class III (P<.001), and the mean BMI increased from 32.1 kg/m2 to 34.4 kg/m2. The increase in BMI was greater in the younger age groups. Adjusted mean BMI increased significantly over 10 years for each of three treatment categories. Conclusion: Extreme degrees of obesity are a common and increasing problem among AI/AN adults with diabetes. We did not find an association between the type of diabetes treatment and the trend toward extreme degrees of obesity. The increase in extreme obesity could potentially affect the burden of morbidity and mortality among AI/AN adults with diabetes. Effective and culturally appropriate weight management interventions are needed.
KW - adults
KW - age differences
KW - age groups
KW - Alaska Natives
KW - American indians
KW - body mass index
KW - diabetes mellitus
KW - epidemics
KW - epidemiology
KW - ethnic groups
KW - obesity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fatness
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073035132&site=ehost-live&scope=site
UR - http://www.cdc.gov/pcd/issues/2007/jan/06_0025.htm
UR - email: charlton.wilson@ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of new tuberculosis vaccines: a global perspective on regulatory issues.
AU - Brennan, M. J.
AU - Fruth, U.
AU - Milstien, J.
AU - Tiernan, R.
AU - Nishioka, S. de A.
AU - Chocarro, L.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2007///
VL - 4
IS - 8
SP - e252
EP - e252
CY - San Francisco; USA
PB - Public Library of Sciences (PLoS)
SN - 1549-1277
AD - Brennan, M. J.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20073269004. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - This article addresses key vaccine and regulatory issues relevant to testing and introducing novel tuberculosis (TB) vaccines into countries where the disease is endemic. Recommendations to regulatory authorities regarding strategies in decision-making for proceeding into various stages of clinical trials and for the final registration of new TB vaccines are discussed.
KW - clinical trials
KW - disease prevention
KW - guidelines
KW - human diseases
KW - immunization
KW - regulations
KW - tuberculosis
KW - vaccination
KW - vaccine development
KW - vaccines
KW - Mycobacterium tuberculosis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - immune sensitization
KW - recommendations
KW - rules
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073269004&site=ehost-live&scope=site
UR - http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pmed.0040252
UR - email: Michael.Brennan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Reconciling competing priorities in commissioning: the future of bone densitometry service for North Wales.
AU - Atenstaedt, R. L.
AU - Payne, S.
AU - Roberts, R.
AU - Russell, I.
AU - Russell, D.
AU - Edwards, R. T.
JO - Cost Effectiveness and Resource Allocation
JF - Cost Effectiveness and Resource Allocation
Y1 - 2007///
VL - 5
IS - 1
SP - (18 January 2007)
EP - (18 January 2007)
CY - London; UK
PB - BioMed Central Ltd
SN - 1478-7547
AD - Atenstaedt, R. L.: National Public Health Service for Wales (North Wales Region), Mold CH7 1PZ, UK.
N1 - Accession Number: 20083083854. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Background: Osteoporosis creates brittle bones susceptible to fracture, with resulting high levels of morbidity and mortality. Poor access to bone densitometry services for the residents of North Wales led to the Welsh Assembly Government offering capital to purchase a dual-energy X-ray absorptiometry (DXA) scanner, used to diagnose osteoporosis, for the region. The commissioning question for the six Local Health Boards across North Wales was where to site the new scanner. This decision needed to reflect current inequalities in access to services and concerns over inappropriate prescribing relative to Welsh norms. Methods: Epidemiological, corporate and comparative healthcare needs assessments were performed. In addition, two cross-sectional surveys were conducted to determine the views of general practices and users of bone densitometry services resident in North Wales. An option appraisal and sensitivity analysis of 13 costed options for DXA scanning was conducted. Results: We estimated that only 31% of the people in North Wales who met national guidelines were receiving DXA scans. There was definite inequity of access to the current service provided by area of residence. There was also evidence of inequity of access by age and sex. The most suitable option identified in the option appraisal was a bone densitometry service based in the central location of Llandudno. Conclusion: The assessment identified significant unmet need for DXA scanning. A recommendation was made to improve access through the introduction of a new bone densitometry service based at Llandudno. This would double scanning provision provided and reduce travel costs and time for many North Wales residents. This recommendation was adopted by a joint commissioning group established by the six Local Health Boards in North Wales at the end of 2004 - evidence based commissioning in practice.
KW - access
KW - bone density
KW - densitometry
KW - diagnosis
KW - diagnostic techniques
KW - health care
KW - health services
KW - human diseases
KW - osteoporosis
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - United Kingdom
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083083854&site=ehost-live&scope=site
UR - http://www.resource-allocation.com/content/pdf/1478-7547-5-1.pdf
UR - email: Robert.Atenstaedt@nphs.wales.nhs.uk\Sandra.Payne@nphs.wales.nhs.uk\Richard.Roberts@nphs.wales.nhs.uk\Ian.Russell@bangor.ac.uk\D.Russell@bangor.ac.uk\r.t.edwards@bangor.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The perils of public transport.
AU - Atenstaedt, R. L.
JO - Travel Medicine and Infectious Disease
JF - Travel Medicine and Infectious Disease
Y1 - 2007///
VL - 5
IS - 1
SP - 51
EP - 52
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1477-8939
AD - Atenstaedt, R. L.: National Public Health Service for Wales (NPHS), Institute of Medical & Social Care Research (IMSCaR), Ardudwy, Normal Site, University of Wales Bangor, Holyhead Road, Gwynedd LL57 2PX, UK.
N1 - Accession Number: 20073034803. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Tropical Diseases; Public Health
N2 - Section 33 of The Public Health (Control of Disease) Act 1984 makes it an offence for a person in England and Wales who is suffering from a notifiable disease, e.g. cholera, to use any bus, tram or train; or use a taxi without notifying the driver or owner of the vehicle, or their carer to allow them to do so. Section 34 of the same act prohibits the owner, driver or conductor of a bus, train or tram from carrying a person who he knows is suffering from one of these diseases. However, a taxi can carry an affected person, provided this individual pays a sum in addition to the fare to cover the costs of disinfection. Assuming that the owner or driver did not know that a passenger was suffering from one of these diseases, he must inform the local authority, which is required to disinfect the taxi for free. A literature review using PubMed did not reveal any evidence that buses, trains, trams or taxis provide a significant vehicle for transmission of notifiable diseases. Is it therefore about time that a non-evidence-based and little-used law is removed from the British statute books?
KW - cholera
KW - infectious diseases
KW - law
KW - transport
KW - England
KW - UK
KW - Wales
KW - Vibrio cholerae
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterium
KW - Britain
KW - communicable diseases
KW - legal aspects
KW - legal principles
KW - transportation
KW - United Kingdom
KW - Laws and Regulations (DD500)
KW - Public Services and Infrastructure (UU300)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073034803&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/14778939
UR - email: Robert.Atenstaedt@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania.
AU - Lee, N.
AU - Gannavaram, S.
AU - Selvapandiyan, A.
AU - Debrabant, A.
JO - Eukaryotic Cell
JF - Eukaryotic Cell
Y1 - 2007///
VL - 6
IS - 10
SP - 1745
EP - 1757
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1535-9778
AD - Lee, N.: Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 29 Lincoln Drive, Bldg. 29, Rm. 425, HFM-310, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083009413. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9002-07-7. Subject Subsets: Protozoology
N2 - In this report, we have characterized two metacaspases of Leishmania donovani, L. donovani metacaspase-1 (LdMC1) and LdMC2. These two proteins show 98% homology with each other, and both contain a characteristic C-terminal proline-rich domain. Both genes are transcribed in promastigotes and axenic amastigotes of L. donovani; however, LdMC1 shows increased mRNA levels in axenic amastigotes. An anti-LdMC antibody was obtained and showed reactivity with a single ~42-kDa protein band in both promastigote and axenic amastigote parasite whole-cell lysates by Western blotting. Pulse-chase experiments suggest that LdMCs are not synthesized as proenzymes, and immunofluorescence studies show that LdMCs are associated with the acidocalcisome compartments of L. donovani. Enzymatic assays of immunoprecipitated LdMCs show that native LdMCs efficiently cleave trypsin substrates and are unable to cleave caspase-specific substrates. Consistently, LdMC activity is insensitive to caspase inhibitors and is efficiently inhibited by trypsin inhibitors, such as leupeptin, antipain, and Nα-tosyl-L-lysine-chloromethyl ketone (TLCK). In addition, our results show that LdMC activity was induced in parasites treated with hydrogen peroxide, a known trigger of programmed cell death (PCD) in Leishmania and that parasites overexpressing metacaspases are more sensitive to hydrogen peroxide-induced PCD. These findings suggest that Leishmania metacaspases are not responsible for the caspase-like activities reported in this organism and suggest a possible role for LdMCs as effector molecules in Leishmania PCD.
KW - amastigotes
KW - apoptosis
KW - trypsin
KW - Leishmania donovani
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - metacaspase
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083009413&site=ehost-live&scope=site
UR - http://ec.asm.org/cgi/content/abstract/6/10/1745
UR - email: alain.debrabant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The relationship between type and quality of social support and HIV medication adherence.
AU - Hamilton, M. M.
AU - Razzano, L. A.
AU - Martin, N. B.
A2 - Ka'opua, L. S.
A2 - Linsk, N. L.
T3 - HIV Treatment Adherence: Challenges for Social Services.
JO - Journal of HIV/AIDS & Social Services
JF - Journal of HIV/AIDS & Social Services
Y1 - 2007///
VL - 6
IS - 1/2
SP - 39
EP - 63
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1538-1501
AD - Hamilton, M. M.: Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL 60603, USA.
N1 - Accession Number: 20073135979. Publication Type: Journal Article. Note: HIV Treatment Adherence: Challenges for Social Services. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - In the last 10 years HIV has become a disease that can be effectively managed using antiretroviral medications. However, many factors affect adherence, including demographics, income, housing, mental health issues, and access to health care, as well as types and quality of social support. This paper summarizes results regarding specific sources of social support that are part of a larger, randomized study of medication adherence among people with HIV/AIDS from Illinois, USA. Results summarize findings from 98 program participants and include information regarding support from partners, family and health care providers, as well as the impact of support from these sources on medication adherence. Among participants in this study, those with higher levels of social support from partners demonstrated higher rates of medication adherence. Those who received more social support from their families, however, reported significantly lower adherence rates. These results suggest that efforts to improve medication adherence need to address the diverse types of social support networks of people diagnosed with HIV/AIDS.
KW - acquired immune deficiency syndrome
KW - antiviral agents
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - patient compliance
KW - personal support networks
KW - Illinois
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - AIDS
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073135979&site=ehost-live&scope=site
UR - email: Mhamilton@psych.uic.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An international review of tobacco smoking in the medical profession: 1974-2004.
AU - Smith, D. R.
AU - Leggat, P. A.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2007///
VL - 7
IS - 115
SP - (20 June 2007)
EP - (20 June 2007)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2458
AD - Smith, D. R.: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan.
N1 - Accession Number: 20073240840. Publication Type: Journal Article. Language: English. Number of References: 127 ref. Subject Subsets: Tropical Diseases
N2 - Background: Tobacco smoking by physicians represents a contentious issue in public health, and regardless of what country it originates from, the need for accurate, historical data is paramount. As such, this article provides an international comparison of all modern literature describing the tobacco smoking habits of contemporary physicians. Methods: A keyword search of appropriate MeSH terms was initially undertaken to identify relevant material, after which the reference lists of manuscripts were also examined to locate further publications. Results: A total of 81 English-language studies published in the past 30 years met the inclusion criteria. Two distinct trends were evident. Firstly, most developed countries have shown a steady decline in physicians' smoking rates during recent years. On the other hand, physicians in some developed countries and newly-developing regions still appear to be smoking at high rates. The lowest smoking prevalence rates were consistently documented in the United States, Australia and the United Kingdom. Comparison with other health professionals suggests that fewer physicians smoke when compared to nurses, and sometimes less often than dentists. Conclusion: Overall, this review suggests that while physicians' smoking habits appear to vary from region to region, they are not uniformly low when viewed from an international perspective. It is important that smoking in the medical profession declines in future years, so that physicians can remain at the forefront of anti-smoking programs and lead the way as public health exemplars in the 21st century.
KW - physicians
KW - reviews
KW - tobacco smoking
KW - world
KW - Developed Countries
KW - Developing Countries
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - countries
KW - doctors
KW - Third World
KW - Underdeveloped Countries
KW - worldwide
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073240840&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/content/pdf/1471-2458-7-115.pdf
UR - email: smith@h.jniosh.go.jp\Peter.Leggat@jcu.edu.au
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using Intervention Mapping to develop a programme to prevent sexually transmittable infections, including HIV, among heterosexual migrant men.
AU - Wolfers, M. E. G.
AU - Hoek, C. van den
AU - Brug, J.
AU - Zwart, O. de
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2007///
VL - 7
IS - 141
SP - (5 July 2007)
EP - (5 July 2007)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2458
AD - Wolfers, M. E. G.: Municipal Public Health Service Rotterdam Area, Rotterdam, Netherlands.
N1 - Accession Number: 20073289996. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Public Health
N2 - Background: There is little experience with carefully developed interventions in the HIV/STI prevention field aimed at adult heterosexual target groups in the Netherlands. The ability to apply intervention development protocols, like Intervention Mapping, in daily practice outside of academia, is a matter of concern. An urgent need also exists for interventions aimed at the prevention of STI in migrant populations in the Netherlands. This article describes the theory and evidence based development of HIV/STI prevention interventions by the Municipal Public Health Service Rotterdam Area (MPHS), the Netherlands, for heterosexual migrant men with Surinamese, Dutch-Caribbean, Cape Verdean, Turkish and Moroccan backgrounds. Methods: First a needs assessment was carried out. Then, a literature review was done, key figures were interviewed and seven group discussions were held. Subsequently, the results were translated into specific objectives ("change objectives") and used in intervention development for two subgroups: men with an Afro-Caribbean background and unmarried men with a Turkish and Moroccan background. A matrix of change objectives was made for each subgroup and suitable theoretical methods and practical strategies were selected. Culturally-tailored interventions were designed and were pre-tested among the target groups. Results: This development process resulted in two interventions for specific subgroups that were appreciated by both the target groups and the migrant prevention workers. The project took place in collaboration with a university center, which provided an opportunity to get expert advice at every step of the Intervention Mapping process. At relevant points of the development process, migrant health educators and target group members provided advice and feedback on the draft intervention materials. Conclusion: This intervention development project indicates that careful well-informed intervention development using Intervention Mapping is feasible in the daily practice of the MPHS, provided that sufficient time and expertise on this approach is available. Further research should test the effectiveness of these interventions.
KW - disease prevention
KW - ethnic groups
KW - ethnicity
KW - heterosexuality
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - men
KW - migrants
KW - migration
KW - needs assessment
KW - program development
KW - sexually transmitted diseases
KW - viral diseases
KW - Netherlands
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - ethnic differences
KW - heterosexuals
KW - human immunodeficiency virus infections
KW - program planning
KW - STDs
KW - venereal diseases
KW - viral infections
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073289996&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/content/pdf/1471-2458-7-141.pdf
UR - email: wolfersm@ggd.rotterdam.nl\vandenhoekk@ggd.rotterdam.nl\j.brug@vumc.nl\dezwarto@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Infections and human tissue transplants: review of FDA MedWatch reports 2001-2004.
AU - Wang, S.
AU - Zinderman, C.
AU - Wise, R.
AU - Braun, M.
T2 - Cell and Tissue Banking
JO - Cell and Tissue Banking
JF - Cell and Tissue Banking
Y1 - 2007///
VL - 8
IS - 3
SP - 211
EP - 219
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 1389-9333
AD - Wang, S.: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20073172827. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - Background - More than 1.5 million tissue allografts are transplanted annually in the U.S. As part of the federal effort to improve tissue safety, FDA's May 2005 Current Good Tissue Practices (CGTP) Rule requires tissue establishments to report to FDA serious infectious adverse events following allograft transplantation. To provide baseline data, we summarize reports of such infections received by FDA prior to the CGTP Rule. Methods - We reviewed reports received by FDA's MedWatch adverse event reporting system during 2001-2004. Our case definition was a reported infection in a human tissue transplant recipient within 1 year of transplantation. We examined demographics, tissue type, clinical outcomes and interventions, infectious organism(s), time from transplant to infection and reporter characteristics. Results - We identified 83 reports of infections following allograft transplantations. Median patient age was 40 years (range: 1 month-87 years). The allografts included heart valves (42%), tendons (33%), bones (8%), blood vessels (6%), ocular tissues (5%), and skin (4%). Commonly reported outcomes and interventions were hospitalization (72%), antibiotic therapy (46%) and graft removal (42%). Nine of 11 patients who expired had received heart valves. In 65 reports that identified suspected organisms, bacteria were most common (42), followed by fungi (25) and prions (1). The median time from transplant to infection was 5.5 weeks (range: 3 days-52 weeks). Tissue manufacturers submitted 26% of reports. Among the remaining 74%, the reporters were quality assurance staff, infection control or risk management personnel (45%); physicians (15%); consumers (15%); nurses (13%); and surgical staff (12%). Conclusion - This is the first review of reports to FDA for infections following allograft tissue transplantations. Infections led to serious outcomes and involved many tissue types. Although we were unable to confirm that reported infections were caused by the suspected tissue product, required reporting by tissue establishments and improvements in adverse event investigation will help to improve tissue safety surveillance.
KW - adverse effects
KW - aetiology
KW - allografts
KW - bacterial diseases
KW - clinical aspects
KW - disease course
KW - human diseases
KW - medical treatment
KW - mortality
KW - mycoses
KW - prion diseases
KW - prions
KW - regulations
KW - reports
KW - reviews
KW - surgical operations
KW - surveillance
KW - transplantation
KW - transplants
KW - USA
KW - bacteria
KW - fungi
KW - man
KW - prokaryotes
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - causal agents
KW - clinical picture
KW - death rate
KW - disease progression
KW - etiology
KW - rules
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073172827&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=104845
UR - email: Craig.zinderman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spirometry as a motivational tool to improve smoking cessation rates: a systematic review of the literature.
AU - Wilt, T. J.
AU - Niewoehner, D.
AU - Kane, R. L.
AU - MacDonald, R.
AU - Joseph, A. M.
JO - Nicotine & Tobacco Research
JF - Nicotine & Tobacco Research
Y1 - 2007///
VL - 9
IS - 1
SP - 21
EP - 32
CY - Abingdon; UK
PB - Informa Healthcare
SN - 1462-2203
AD - Wilt, T. J.: Minnesota Agency for Healthcare Research and Quality Evidence-based Practice Center, Minneapolis Veterans Affairs (VA) Center for Chronic Disease Outcomes Research and Section of General Medicine, Minneapolis, Minnesota, USA.
N1 - Accession Number: 20083053337. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Obtaining spirometric testing and providing those results to individuals who smoke has been advocated as a motivational tool to improve smoking cessation. However, its effectiveness is not known. We conducted a systematic review to determine if this approach improves rates of smoking cessation. Data sources included MEDLINE (1966 to October 2005), the Cochrane Library, and experts in the field. Eligible randomized controlled trials (RCTs) enrolled at least 25 smokers per arm, evaluated spirometry with associated counselling or in combination with other treatments, followed subjects at least 6 months, and provided smoking abstinence rates. Results from nonrandomized studies also were summarized. The primary outcome was patient-reported long-term (at least 6 months) sustained abstinence with biological validation. Additional outcomes included self-reported abstinence and point-prevalence abstinence. Seven RCTs (N=6,052 subjects) met eligibility criteria. Follow-up duration ranged from 9 to 36 months. In six trials, the intervention group received concomitant treatments previously demonstrated to increase cessation independently. The range of abstinence was 3%-14% for control subjects and 7%-39% among intervention groups, statistically significantly in favour of intervention in four studies. The only RCT that assessed the independent contribution of spirometry in combination with counselling demonstrated a nonsignificant 1% improvement in patient-reported point-prevalence abstinence at 12 months in the group that received spirometry plus counselling versus counselling alone (6.5% versus 5.5%). Findings from observational studies were mixed, and the lack of controls makes interpretation problematic. Available evidence is insufficient to determine whether obtaining spirometric values and providing that information to patients improves smoking cessation compared with other smoking cessation methods. Spirometric values are of limited benefit as a predictor of smoking cessation or as a tool to "customize" smoking cessation strategies.
KW - counselling
KW - effects
KW - follow up
KW - literature reviews
KW - tobacco smoking
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cessation
KW - counseling
KW - Health Services (UU350)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083053337&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a770437525~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Development of a field method for measuring manganese in welding fume.
AU - Marcy, A. D.
AU - Drake, P. L.
T2 - Journal of Environmental Monitoring
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2007///
VL - 9
IS - 11
SP - 1199
EP - 1204
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 1464-0325
AD - Marcy, A. D.: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave, Spokane, WA 99207, USA.
N1 - Accession Number: 20073263420. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 7439-96-5. Subject Subsets: Public Health
N2 - Workers who perform routine welding tasks are potentially exposed to fume that may contain manganese. Manganese may cause respiratory problems and is implicated in causing the occurrence of Parkinson-like symptoms. In this study, a field colorimetric method for extracting and measuring manganese in welding fume was developed. The method uses ultrasonic extraction with an acidic hydrogen peroxide solution to extract welding fume collected on polyvinyl chloride filters. Commercially available pre-packaged reagents are used to produce a colored solution, created by a reaction of manganese(II) with 1-(2-pyridylazo)-2-naphthol. Absorbance measurements are then made using a portable spectrophotometer. The method detection limit and limit of quantification (LOQ) were 5.2 µg filter-1 and 17 µg filter-1, respectively, with a dynamic range up to 400 µg filter-1. When the results are above the LOQ for the colorimetric method, the manganese masses are equivalent to those measured by the International Organization for Standardization Method 15202-2, which employs a strong acid digestion and analysis using inductively coupled plasma-optical emission spectrometry.
KW - extraction
KW - fumes
KW - manganese
KW - measurement
KW - methodology
KW - occupational hazards
KW - quantitative techniques
KW - welding
KW - methods
KW - metrology
KW - Mn
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073263420&site=ehost-live&scope=site
UR - http://www.rsc.org/jem
UR - email: pdrake@.cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance for pesticide-related disease.
AU - Osorio, A. M.
A2 - Osorio, A. M.
A2 - Goldman, L. R.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007///
VL - 12
IS - 1
SP - 57
EP - 66
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - Osorio, A. M.: U.S. Food and Drug Administration-Pacific Regional Office, 1301 Clay Street, Suite 1180N, Oakland, CA, 94612, USA.
N1 - Accession Number: 20073250911. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - Public health surveillance for acute pesticide intoxications is discussed. Explanation of the goals, components and functions of population-based surveillance is provided with reference to key informational sources. Both a state-based pesticide intoxication program and a nearly nationwide poison control center data base program are used to illustrate the potential uses inherent in these types of system. There is additional discussion on the investigation of disease clusters, the use of complementary exposure monitoring data and confidentiality issues.
KW - exposure
KW - human diseases
KW - pesticides
KW - public health
KW - surveillance
KW - toxic substances
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - poisons
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073250911&site=ehost-live&scope=site
UR - http://www.haworthpress.com/web/JA/
UR - email: anamaria.osorio@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A task-based assessment of noise levels at a swine confinement.
AU - Achutan, C.
AU - Tubbs, R. L.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007///
VL - 12
IS - 2
SP - 55
EP - 65
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - Achutan, C.: Hazard Evaluations and Technical Assistance Branch, National Institute for Occupational Safety and Health, NIOSH, 4676 Columbia Parkway MS R-11, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083045457. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health; Pig Science
N2 - This study describes a task-based noise evaluation conducted at a community college that operated a small swine confinement for training and profit. Seven full-shift dosimeter samples and area noise data were collected during the evaluation. The time weighted average noise levels were all well below the Occupational Safety and Health Administration's (OSHA) Permissible Exposure Limit, but exceeded the National Institute for Occupational Safety and Health's Recommended Exposure Limit on three of seven occasions. The potential for high noise exposures is evidenced in the noise dose measured for specific activities such as power washing, ear clipping, and snout snaring. When the data were extrapolated to depict exposures where specific tasks were carried out over a full shift, tasks such as power washing and snout snaring would exceed the OSHA Action Level (AL). Employees who exceed the OSHA AL are required to be enrolled in a hearing conservation program.
KW - hearing
KW - hearing impairment
KW - noise
KW - occupational hazards
KW - occupational health
KW - pig housing
KW - Iowa
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - piggeries
KW - sties
KW - swine housing
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083045457&site=ehost-live&scope=site
UR - http://www.haworthpress.com/store/product.asp?sku=J096
UR - email: cma4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of nutrition labeling and claims on processed, and packaged foods.
AU - Kwon KwangIl
AU - Park SoHyun
AU - Lee JunHyung
AU - Kim JeeYoung
AU - Yoo KwangSoo
AU - Lee JeeSun
AU - Kim SeoYoung
AU - Sung HyuNi
AU - Nam HyeSeon
AU - Kim JongWook
AU - Lee HyeYoung
AU - Park HyeKyung
AU - Kim MyungChul
JO - Korean Journal of Community Nutrition
JF - Korean Journal of Community Nutrition
Y1 - 2007///
VL - 12
IS - 2
SP - 206
EP - 213
CY - Seoul; Korea Republic
PB - Korean Society of Community Nutrition
SN - 1226-0983
AD - Kwon KwangIl: Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20073240497. Publication Type: Journal Article. Language: Korean. Language of Summary: English. Number of References: 20 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology; Rural Development
N2 - This study investigated the prevalence of nutrition labelling and claims on processed and packaged foods. The final database consisted of 1287 foods, which were purchased from two supermarkets in Seoul, Korea Republic between September and November 2006. An estimated 78% of the Korean Food and Drug Administration-regulated processed and packaged foods had nutrition labels. Nutrient content claims on food labels were identified in 21% of the foods with nutrition labels. The prevalence of nutrition labels in this study was much higher than in previous studies due to the current expansion of the mandatory labelling regulation. However, false labelling and misleading contents claims were also identified. The food label is an important tool for enhancing the public's understanding of healthy food products. Therefore, to maximize the benefits of the nutrition labelling regulation, industries, government agencies and health professionals should work together to help consumers make healthy dietary choices and improve their health.
KW - consumer information
KW - consumers
KW - food products
KW - food quality
KW - health claims
KW - nutrients
KW - nutrition labeling
KW - nutritive value
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - nutritional value
KW - quality for nutrition
KW - South Korea
KW - Marketing and Distribution (EE700)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073240497&site=ehost-live&scope=site
UR - http://koscom.or.kr
UR - email: phkfda@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Longitudinal trends of alcohol and tobacco consumption among Australian physicians and nurses, 1989-2005.
AU - Smith, D. R.
JO - Journal of Substance Use
JF - Journal of Substance Use
Y1 - 2007///
VL - 12
IS - 4
SP - 267
EP - 280
CY - Abingdon; UK
PB - Informa Healthcare
SN - 1465-9891
AD - Smith, D. R.: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan.
N1 - Accession Number: 20083169753. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Public Health
N2 - Aim: This study examined alcohol and tobacco consumption trends among a national sample of Australian health care workers between 1989 and 2005. Method: Alcohol and tobacco smoking data specific for physicians and nurses was obtained during four national health surveys. Data were analysed by alcohol consumption level, tobacco smoking status, job category and year of study. The relative risk of substance use between physicians, nurses and the general Australian population was also evaluated. Results: The proportion of Australian physicians and nurses with risky alcohol consumption habits appears to have fluctuated over time, particularly among nurses. Although tobacco smoking among Australian nurses has declined in recent years, the relatively low proportion of physician smokers remained fairly stable over the same time period. Both professional groups were considerably less likely to use tobacco when compared with the general population. Conclusion: This study provides one of the first clear insights into longitudinal substance use trends among Australian health care workers during the past 17 years. A sustained reduction in alcohol and tobacco use must continue in future, so that they remain exemplars at the forefront of anti-substance abuse programmes in the community.
KW - alcohol intake
KW - consumption
KW - health
KW - health care
KW - health care workers
KW - physicians
KW - surveys
KW - tobacco
KW - tobacco smoking
KW - workers
KW - Australia
KW - man
KW - Nicotiana
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - alcohol
KW - alcohol consumption
KW - doctors
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Health Services (UU350)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083169753&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a781022521~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethical and Scientific Issues of Nanotechnology in the Workplace.
AU - Schulte, P. A.
AU - Salamanca-Buentello, F.
JO - Ciência & Saúde Coletiva
JF - Ciência & Saúde Coletiva
Y1 - 2007///
VL - 12
IS - 5
SP - 1319
EP - 1332
CY - Rio de Janeiro; Brazil
PB - Associacao Brasileira de Pos-Graduacao em Saude Coletiva
SN - 1413-8123
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083118783. Publication Type: Journal Article. Language: English. Language of Summary: Portuguese. Number of References: 85 ref. Subject Subsets: Public Health
N2 - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decisionmaking about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the (a) identification and communication of hazards and risks by scientists, authorities, and employers; (b) workers' acceptance of risk; (c) selection and implementation of controls; (d) establishment of medical screening programmes; and (e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective.
KW - bioethics
KW - occupational hazards
KW - occupational health
KW - risk
KW - safety at work
KW - toxic substances
KW - work places
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - occupational safety
KW - poisons
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083118783&site=ehost-live&scope=site
UR - http://www.scielo.br/pdf/csc/v12n5/24.pdf
UR - email: pschulte@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors determining use of pre-travel preventive health services by West African immigrants in The Netherlands.
AU - Schilthuis, H. J.
AU - Goossens, I.
AU - Ligthelm, R. J.
AU - Vlas, S. J. de
AU - Varkevisser, C.
AU - Richardus, J. H.
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
Y1 - 2007///
VL - 12
IS - 8
SP - 990
EP - 998
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1360-2276
AD - Schilthuis, H. J.: Municipal Public Health Service, Amsterdam, Netherlands.
N1 - Accession Number: 20073212665. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 26 ref. Subject Subsets: Public Health; Protozoology; Tropical Diseases; Leisure, Recreation, Tourism; Rural Development
N2 - OBJECTIVE: To determine for what reasons West African immigrants, who contribute the largest single group of malaria cases in the Netherlands, visit pre-travel preventive health services and whether use of such services is likely to improve use of preventive measures. METHODS: Semi-structured interviews with eligible participants recruited through West African churches and societies and at a large festival. RESULTS: A total of 70% of the total non-random sample of 292 participants said that they always use pre-travel preventive health services before travelling. Being from Ghana (OR=2.5), having legal residency status (OR=2.5), visiting friends and relatives rather than going for business or funeral (OR=6.7), and living in Amsterdam (OR=5.1) were all independently associated with using pre-travel preventive health services, as were taking general preventive measures (OR=3.0), and self-reported use of malaria prophylaxis. Higher use of pre-travel preventive health services was not associated with better knowledge of malaria as such. CONCLUSIONS: West Africans, in particular non-Ghanaians, illegal immigrants and West African immigrants leaving at short notice should be encouraged to use pre-travel preventive health services. Adequate methods to reach these groups need to be developed, including health education on the importance of prevention in general.
KW - disease prevention
KW - health services
KW - human diseases
KW - immigrants
KW - immunization
KW - imported infections
KW - malaria
KW - prophylaxis
KW - protozoal infections
KW - travel
KW - vaccination
KW - Netherlands
KW - West Africa
KW - man
KW - Plasmodium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - Africa South of Sahara
KW - Africa
KW - immune sensitization
KW - protozoal diseases
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Tourism and Travel (UU700)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073212665&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/tmi
UR - email: j.richardus@erasmusmc.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Installing a cost-effective rollover protective structure (CROPS): a cost-effectiveness analysis.
AU - Owusu-Edusei, X., Jr.
AU - Biddle, E. A.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2007///
VL - 13
IS - 2
SP - 165
EP - 176
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Owusu-Edusei, X., Jr.: Division Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073114448. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Agricultural Engineering; World Agriculture, Economics & Rural Sociology
N2 - Cost-effective rollover protective structures (CROPS) are tractor model-specific rollover protective structures (ROPS) that are as effective as existing ROPS retrofits (passed standardized structural static testing such as SAE J2194), but less costly (less than one-half the cost of existing ROPS retrofits). This study estimated the expected effects and costs at a per-tractor level for two options: No-CROPS and Install-CROPS. Expected injuries per tractor were 0.00169 with no CROPS and 0.00016 with CROPS installed, resulting in 0.00153 injuries prevented per tractor over a 20-year period. Expected costs were $457 and $248 with and without CROPS, respectively, over the same time period, giving the cost per injury prevented as $136 601. Comprehensive sensitivity analyses indicated that the probability of an overturn is one of the most important variables. When the cost of intervention ($1,000 for purchasing, shipping, and installation of ROPS retrofit) is used in the analysis, the cost-effectiveness ratio is $497 000 per injury prevented over the 20-year period. Thus, installing CROPS instead of existing ROPS retrofits improved the cost-effectiveness ratio substantially, with a 73% reduction in the net cost per injury prevented.
KW - cost effectiveness analysis
KW - occupational hazards
KW - overturning
KW - roll over protection structures
KW - safety at work
KW - safety devices
KW - tractors
KW - trauma
KW - antiroll structures
KW - occupational safety
KW - traumas
KW - Occupational Health and Safety (VV900)
KW - Input Supply Industries (Macroeconomics) (EE140)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073114448&site=ehost-live&scope=site
UR - http://www.asabe.org/
UR - email: kfo0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A stable dynamic cohort analysis of installing cost-effective rollover protective structures (CROPS).
AU - Owusu-Edusei, K., Jr.
AU - Biddle, E. A.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2007///
VL - 13
IS - 2
SP - 177
EP - 187
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Owusu-Edusei, K., Jr.: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073114449. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Agricultural Engineering
N2 - Cost-effective rollover protective structures (CROPS) are less costly model-specific rollover protective structure (ROPS) retrofits that are being developed and evaluated with the hope of increasing adoption and eventually preventing or mitigating injuries due to tractor overturns. A dynamic cohort of the estimated retrofittable non-ROPS tractors (accounting for attrition due to aging) was tracked over a 20-year period to determine the expected costs, as well as the expected number of fatal and non-fatal injuries resulting from tractor overturns. Two alternatives were tracked: No-ROPS and Install-CROPS. For a starting cohort size of 1 065 164 (an estimate for the year 2004), the Install-CROPS option prevented an estimated total of 878 (192 fatal and 686 non-fatal) injuries over the 20-year period. Expected costs were $513 million (cost of installing CROPS on all the non-ROPS tractors plus cost of the associated injuries) and $284 million (cost of injuries resulting from the No-ROPS option) over the same time period. Thus, the net cost per injury prevented was $260 820. When the cost of intervention ($1,000 for purchasing, shipping, and installation of existing ROPS retrofit) was used in the analysis, the cost-effectiveness ratio was $927 000 per injury prevented over the 20-year period. Thus, installing CROPS instead of existing ROPS retrofits improved the cost-effectiveness ratio substantially, with a 72% reduction in the net cost per injury prevented.
KW - cost effectiveness analysis
KW - occupational hazards
KW - overturning
KW - roll over protection structures
KW - safety at work
KW - trauma
KW - antiroll structures
KW - occupational safety
KW - traumas
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073114449&site=ehost-live&scope=site
UR - http://www.asabe.org/
UR - email: kfo0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fungicide application practices and personal protective equipment use among Orchard Farmers in the Agricultural Health Study.
AU - Hines, C. J.
AU - Deddens, J. A.
AU - Coble, J.
AU - Alavanja, M. C. R.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2007///
VL - 13
IS - 2
SP - 205
EP - 223
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Hines, C. J.: National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, R-14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073114451. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health; Agricultural Engineering; Plant Pathology
N2 - Fungicides are routinely applied to deciduous tree fruits for disease management. Seventy-four private orchard applicators enrolled in the Agricultural Health Study participated in the Orchard Fungicide Exposure Study in 2002-2003. During 144 days of observation, information was obtained on chemicals applied and applicator mixing, application, personal protective, and hygiene practices. At least half of the applicators had orchards with ≤100 trees. Air blast was the most frequent application method used (55%), followed by hand spray (44%). Rubber gloves were the most frequently worn protective equipment (68% mix; 59% apply), followed by respirators (45% mix; 49% apply), protective outerwear (36% mix; 37% apply), and rubber boots (35% mix; 36% apply). Eye protection was worn while mixing and applying on only 35% and 41% of the days, respectively. Bivariate analyses were performed using repeated logistic or repeated linear regression. Mean duration of mixing, pounds of captan applied, total acres sprayed, and number of tank mixes sprayed were greater for air blast than for hand spray (p<0.05). Spraying from a tractor/vehicle without an enclosed cab was associated with wearing some type of coverall (p<0.05). Applicators often did not wash their hands after mixing (77%), a finding not explained by glove use. Glove use during mixing was associated with younger age, while wearing long-sleeve shirts was associated with older age (p<0.05 each). Self-reported unusually high fungicide exposures were more likely on days applicators performed repairs (p<0.05). These data will be useful for evaluating fungicide exposure determinants among orchard applicators.
KW - applicators
KW - exposure
KW - farm workers
KW - fungicide residues
KW - fungicides
KW - human diseases
KW - occupational hazards
KW - orchards
KW - protective clothing
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungistats
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073114451&site=ehost-live&scope=site
UR - http://www.asabe.org/
UR - email: chines@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Avian influenza risk perception, Europe and Asia.
AU - Zwart, O. de
AU - Veldhuijzen, I. K.
AU - Elam, G.
AU - Aro, A. R.
AU - Abraham, T.
AU - Bishop, G. D.
AU - Richardus, J. H.
AU - Brug, J.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 2
SP - 290
EP - 293
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Zwart, O. de: Municipal Public Health Service Rotterdam Area, Division of Infectious Disease Control, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20073051652. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health; Poultry
N2 - During autumn 2005, we conducted 3,436 interviews in European and Asian countries. We found risk perceptions of avian influenza to be at an intermediate level and beliefs of efficacy to be slightly lower. Risk perceptions were higher in Europe than in Asia; efficacy beliefs were lower in Europe than in Asia.
KW - avian influenza
KW - avian influenza A viruses
KW - avian influenza viruses
KW - beliefs
KW - human diseases
KW - influenza viruses
KW - risk
KW - Asia
KW - Europe
KW - Influenza A virus
KW - man
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Avian influenzavirus
KW - bird flu
KW - bird grippe
KW - bird influenza
KW - fowl plague virus
KW - Influenzavirus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073051652&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: dezwarto@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology of community-associated antimicrobial-resistant Staphylococcus aureus in Seoul, Korea (2003): pervasiveness of multidrug-resistant SCCmec type II methicillin-resistant S. aureus.
AU - Jeong HyeYoon
AU - Lee JungEun
AU - Choi BoKyung
AU - Seo KyungWon
AU - Park SeungHee
AU - Kim YoungLim
AU - Baek KyoungMin
AU - Lee KyungWon
AU - Rhee DongKwon
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
Y1 - 2007///
VL - 13
IS - 3
SP - 178
EP - 185
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1076-6294
AD - Jeong HyeYoon: Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20083008867. Publication Type: Journal Article. Language: English. Registry Number: 58-71-9, 153-61-7, 85721-33-1, 18323-44-9, 114-07-8, 1403-66-3, 1405-41-0, 61-32-5, 66-79-5, 723-46-6, 60-54-8, 64-75-5, 738-70-5. Subject Subsets: Tropical Diseases
N2 - There is an extremely high incidence of antimicrobial resistance of the clinical isolates of Staphylococcus aureus in Korea. This study carried out a molecular investigation to determine the prevalence of the community-associated antimicrobial-resistant S. aureus and methicillin-resistant S. aureus (MRSA). The percentage resistance from the nasal swabs of healthy volunteers in 2003 in Seoul is as follows: penicillin (91%), erythromycin (EM, 14%), gentamicin (GM, 9.3%), tetracycline (TE, 8.2%), cephalothin (4%), oxacillin (OX, MRSA; 3.8%), clindamycin (CC, 2.6%), ciprofloxacin (CIP, 0.8%), and sulfamethoxazole/trimethoprim (0.6%). The community-associated MRSA (C-MRSA) strains were examined by pulsed-field gel electrophoresis (PFGE) analysis of the SmaI macro-fragments, multilocus sequence typing (MLST), and staphylococcal cassette chromosome mec (SCCmec) typing using the PCR analysis. The Korean C-MRSA isolates were clustered into three distinct groups. One PFGE group containing the C-MRSA strains showed resistance to CC, EM, and GM, a high level (32-96 µg/ml) of resistance to methicillin, sequence type 5 (ST5), and SCCmec type II, which is the most common hospital associated-MRSA (H-MRSA) isolated in Korea. These results highlight the heterogeneous genetic background of the C-MRSA as well as the pervasiveness of the H-MRSA isolates in this community.
KW - antibacterial agents
KW - bacterial diseases
KW - cefalotin
KW - ciprofloxacin
KW - clindamycin
KW - disease prevalence
KW - erythromycin
KW - genes
KW - genotypes
KW - gentamicin
KW - human diseases
KW - methicillin
KW - molecular epidemiology
KW - multiple drug resistance
KW - oxacillin
KW - penicillins
KW - strains
KW - sulfamethoxazole
KW - tetracycline
KW - trimethoprim
KW - Korea Republic
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - achromycin
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cephalothin
KW - South Korea
KW - sulphamethoxazole
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083008867&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/abs/10.1089/mdr.2007.709
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1.
AU - Tompkins, S. M.
AU - Zhao, Z. S.
AU - Lo, C. Y.
AU - Misplon, J. A.
AU - Liu, T.
AU - Ye, Z. P.
AU - Hogan, R. J.
AU - Wu, Z. Q.
AU - Benton, K. A.
AU - Tumpey, T. M.
AU - Epstein, S. L.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 3
SP - 426
EP - 435
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Tompkins, S. M.: Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20073070171. Publication Type: Journal Article. Language: English. Number of References: 22 ref.
N2 - Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected against challenge with lethal influenza. Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and produced T-cell responses. This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A.
KW - animal models
KW - candidate vaccines
KW - DNA vaccines
KW - human diseases
KW - immunization
KW - influenza viruses
KW - laboratory animals
KW - vaccination
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - immune sensitization
KW - Influenzavirus
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073070171&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: tompkins@vet.uga.edu
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Estimation of excess cancer risk on time-weighted Lifetime Average Daily Intake of PAHs from food ingestion.
AU - Yoon EunKyung
AU - Park KyunGah
AU - Lee HyoMin
AU - Yang JaeHo
AU - Lee, C.
T2 - Human and Ecological Risk Assessment
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
Y1 - 2007///
VL - 13
IS - 3
SP - 669
EP - 680
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 1080-7039
AD - Yoon EunKyung: Department of Risk Assessment Research, Korea Food and Drug Administration, Eunpyung-ku, Seoul, Korea Republic.
N1 - Accession Number: 20073150918. Publication Type: Journal Article. Language: English. Registry Number: 50-32-8. Subject Subsets: Tropical Diseases
N2 - The purposes of this study were to quantify the time-weighted, lifetime average, daily intake (LADI) of polycyclic aromatic hydrocarbons (PAHs) through food ingestion and to estimate the excess cancer risk based on lifetime dietary PAH intake. Twenty-seven different food commodities were selected from the 2001 Korean National Health and Nutrition survey based on their frequent consumption and high PAH level. The foods were analysed for the profile of 14 PAH congeners using high performance liquid chromatography (HPLC) and fluorescence detector. Considering the toxic equivalent (TEQ) level converted with the toxic equivalent factors (TEFs), the highest total TEQ level of PAHs in foods was detected from roasted laver at 1.2 µg TEQ/kg. For the PAH exposure assessment according to ingested foods, the average body weight was separated according to the following age groups, 1-6, 7-19, 20-64 and over 64 years, and the daily food ingestion rates from the National Health and Nutrition survey were used. The estimated Lifetime Average Daily Intake (LADI) of PAHs was 3.22×10-3µg/kg/day for carcinogenic effects and was higher in the younger age groups under 20 years old than in the older groups. The dietary excess cancer risk estimated using the cancer potency of benzo(a)pyrene (7.3(mg/kg/day)-1) was 2.3×10-5, which is equivalent to a probability of tumour eruption in the upper gastrointestinal tract of two per hundred thousand persons.
KW - adults
KW - aromatic hydrocarbons
KW - benzopyrene
KW - carcinogens
KW - children
KW - diet
KW - elderly
KW - epidemiology
KW - exposure
KW - food contamination
KW - food intake
KW - human diseases
KW - infants
KW - intake
KW - neoplasms
KW - polycyclic hydrocarbons
KW - risk assessment
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - aged
KW - cancers
KW - elderly people
KW - food contaminants
KW - older adults
KW - polycyclic aromatic hydrocarbons
KW - senior citizens
KW - South Korea
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073150918&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a778594448~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Respirator donning in post-hurricane New Orleans.
AU - Cummings, K. J.
AU - Cox-Ganser, J.
AU - Riggs, M. A.
AU - Edwards, N.
AU - Kreiss, K.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 5
SP - 700
EP - 707
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Cummings, K. J.: National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Mailstop 2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073115383. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Soils & Fertilizers; Public Health
N2 - We evaluated correctness of N95 filtering facepiece respirator donning by the public in post-hurricane New Orleans, where respirators were recommended for mold remediation. We randomly selected, interviewed, and observed 538 participants, using multiple logistic regression for analysis. Only 129 (24%) participants demonstrated proper donning. Errors included nose clip not tightened (71%) and straps incorrectly placed (52%); 22% put on the respirator upside down. Factors independently associated with proper donning were as follows: ever having used a mask or respirator (odds ratio [OR] 5.28; 95% confidence interval [CI], 1.79-22.64); ever having had a respirator fit test (OR 4.40; 95% CI, 2.52-7.81); being male (OR 2.44; 95% CI, 1.50-4.03); Caucasian race (OR 2.09; 95% CI, 1.32-3.33); having a certified respirator (OR 1.99, 95% CI 1.20-3.28); and having participated in mold clean-up (OR 1.82; 95% CI,1.00-3.41). Interventions to improve respirator donning should be considered in planning for influenza epidemics and disasters.
KW - disease prevention
KW - equipment
KW - health protection
KW - human diseases
KW - hurricanes
KW - influenza
KW - Influenza viruses
KW - natural disasters
KW - Louisiana
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - West South Central States of USA
KW - flu
KW - respirators
KW - United States of America
KW - Natural Disasters (PP800)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073115383&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: cvx5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emergence of serotype G12 rotaviruses, Hungary.
AU - Bányai, K.
AU - Bogdán, Á.
AU - Kisfali, P.
AU - Molnár, P.
AU - Mihály, I.
AU - Melegh, B.
AU - Martella, V.
AU - Gentsch, J. R.
AU - Szücs, G.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 6
SP - 916
EP - 919
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Bányai, K.: Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623, Pécs, Hungary.
N1 - Accession Number: 20073140209. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - We describe the emergence of serotype G12 rotaviruses (67 [6.9%] of 971 specimens tested) among children hospitalized with rotavirus gastroenteritis in Hungary during 2005. These findings are consistent with recent reports of the possible global spread and increasing epidemiologic importance of these strains, which may have implications for current rotavirus vaccination strategies.
KW - children
KW - gastroenteritis
KW - human diseases
KW - serotypes
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073140209&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emergency Use Authorization (EUA) to enable use of needed products in civilian and military emergencies, United States.
AU - Nightingale, S. L.
AU - Prasher, J. M.
AU - Simonson, S.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 7
SP - 1046
EP - 1051
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Nightingale, S. L.: US Department of Health and Human Services, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20073159798. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - The US Emergency Use Authorization (EUA) is a critical new tool for medical and public health communities and is applicable for both civilian and military use. It fills the need for timely and practical medical treatment under emergency conditions and authorizes use of the best product available for treatment or prevention when the relevant product has not already been approved or approved for this specific use by the US Food and Drug Administration. The need for and genesis of the EUA, its requirements, its broad application to civilian and military populations, and its features of particular importance to physicians and public health officials are detailed.
KW - emergencies
KW - human diseases
KW - infectious diseases
KW - public health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - emergency use authorization
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073159798&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: nightins@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic diversity among clonal lineages within Escherichia coli O157:H7 stepwise evolutionary model.
AU - Feng, P. C. H.
AU - Monday, S. R.
AU - Lacher, D. W.
AU - Allison, L.
AU - Siitonen, A.
AU - Keys, C.
AU - Eklund, M.
AU - Nagano, H.
AU - Karch, H.
AU - Keen, J.
AU - Whittam, T. S.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007///
VL - 13
IS - 11
SP - 1701
EP - 1706
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Feng, P. C. H.: HFS-711, Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20073285288. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Escherichia coli O157:H7 variants were examined for trait mutations and by molecular subtyping to better define clonal complexes postulated on the O157:H7 evolution model. Strains of β-glucuronidase-positive, sorbitol-negative O157:H7 isolated in United States and Japan were identical to A5 clonal strain and shared sequence type (ST)-65 by multilocus sequence typing (MLST); thus, they belong in A5. However, these strains exhibited pulsed-field gel electrophoresis (PFGE) profile differences that suggested genomic divergence between populations. Sorbitol-fermenting O157 (SFO157) strains from Finland, Scotland, and Germany were identical to A4 clonal strain and belong in A4. Some SFO157 strains, isolated years apart and from different countries, had identical PFGE profiles, suggesting a common origin. Despite similarities, some Finnish and Scottish and all of the German strains have ST-75 ("German clone"), whereas others have ST-76, a new variant ("Scottish clone"). MLST of strains in other clonal complexes also discriminated strains thought to be identical and showed that genetic differences will further distinguish clonal populations into subclones.
KW - bacterial diseases
KW - clones
KW - evolution
KW - genetic diversity
KW - mutations
KW - strains
KW - Finland
KW - Germany
KW - Japan
KW - Scotland
KW - UK
KW - USA
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Scandinavia
KW - Northern Europe
KW - Europe
KW - Western Europe
KW - APEC countries
KW - East Asia
KW - Asia
KW - Great Britain
KW - UK
KW - British Isles
KW - Commonwealth of Nations
KW - North America
KW - America
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - E. coli
KW - United Kingdom
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073285288&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: peter.feng@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National policies for xenotransplantation in the USA.
AU - Bloom, E. T.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2007///
VL - 14
IS - 4
SP - 345
EP - 346
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0908-665X
AD - Bloom, E. T.: Gene Transfer and Immunogenicity Branch (HFM-725), Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20073262104. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - An overview of xenotransplantation regulatory policies in the USA was presented at the Satellite Symposium, "Xenotransplantation - Current Standards for Clinical Trials," held in conjunction with the World Transplant Congress, Boston, MA, USA 2006. This article summarizes that overview.
KW - regulations
KW - reviews
KW - surgery
KW - surgical operations
KW - transplants
KW - xenotransplantation
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073262104&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/xen
UR - email: eda.bloom@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Characterization and use of mammalian-expressed vaccinia virus extracellular membrane proteins for quantification of the humoral immune response to smallpox vaccines.
AU - García, A. D.
AU - Meseda, C. A.
AU - Mayer, A. E.
AU - Kumar, A.
AU - Merchlinsky, M.
AU - Weir, J. P.
T2 - Clinical and Vaccine Immunology
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2007///
VL - 14
IS - 8
SP - 1032
EP - 1044
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - García, A. D.: Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-457, Rockville, MD 20892, USA.
N1 - Accession Number: 20073196854. Publication Type: Journal Article. Language: English. Number of References: 63 ref.
N2 - The licensed smallpox vaccine Dryvax is used as the standard in comparative immunogenicity and protection studies of new smallpox vaccine candidates. Although the correlates of protection against smallpox are unknown, recent studies have shown that a humoral response against the intracellular mature virion and extracellular enveloped virion (EV) forms of vaccinia virus is crucial for protection. Using a recombinant Semliki Forest virus (rSFV) vector system, we expressed a set of full-length EV proteins for the development of EV antigen-specific enzyme-linked immunosorbent assays (ELISAs) and the production of monospecific antisera. The EV-specific ELISAs were used to evaluate the EV humoral response elicited by Dryvax and the nonreplicating modified vaccinia virus Ankara (MVA) in mouse vaccination experiments comparing doses and routes of vaccination. Quantitatively similar titers of antibodies against EV antigens A33R, A56R, and B5R were measured in mice vaccinated with Dryvax and MVA when MVA was administered at a dose of 108 plaque-forming units. Further, a substantial increase in the EV-specific antibody response was induced in mice inoculated with MVA by using a prime-boost schedule. Finally, we investigated the abilities of the EV-expressing rSFV vectors to elicit the production of polyclonal monospecific antisera against the corresponding EV proteins in mice. The monospecific serum antibody levels against A33R, A56R, and B5R were measurably higher than the antibody levels induced by Dryvax. The resulting polyclonal antisera were used in Western blot analysis and immunofluorescence assays, indicating that rSFV particles are useful vectors for generating monospecific antisera.
KW - animal models
KW - antibodies
KW - experimental infections
KW - immune response
KW - immune serum
KW - immunization
KW - laboratory animals
KW - smallpox
KW - surface proteins
KW - vaccination
KW - vaccines
KW - mice
KW - vaccinia virus
KW - Variola virus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - antiserum
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - membrane proteins
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073196854&site=ehost-live&scope=site
UR - email: alonzo.garcia@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Validation of a microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin M antibodies.
AU - Johnson, A. J.
AU - Cheshier, R. C.
AU - Cosentino, G.
AU - Masri, H. P.
AU - Mock, V.
AU - Oesterle, R.
AU - Lanciotti, R. S.
AU - Martin, D. A.
AU - Panella, A. J.
AU - Kosoy, O.
AU - Biggerstaff, B. J.
T2 - Clinical and Vaccine Immunology
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2007///
VL - 14
IS - 9
SP - 1084
EP - 1093
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Johnson, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 3150 Rampart Rd., Foothills Campus, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20073233550. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - A microsphere-based immunoassay (MIA) was previously developed that is capable of determining the presence of anti-West Nile (WN) virus or anti-St. Louis encephalitis (SLE) virus immunoglobulin M (IgM) antibodies in human serum or cerebrospinal fluid. The original data set on which the classification rules were based comprised 491 serum specimens obtained from the serum bank at the Division of Vector-Borne Infectious Diseases of the Centers for Disease Control and Prevention (DVBID). The classification rules were used to provide a result and to determine whether confirmatory testing was necessary for a given sample. A validation study was coordinated between the DVBID and five state health laboratories to determine (i) the reproducibility of the test between different laboratories, (ii) the correlation between the IgM-enzyme-linked immunosorbent assay (MAC-ELISA) and the MIA, and (iii) whether the initial nonspecific parameters could be refined to reduce the volume of confirmatory testing. Laboratorians were trained in the method, and reagents and data analysis software developed at the DVBID were shipped to each validating laboratory. Validating laboratories performed tests on approximately 200 samples obtained from their individual states, the collections of which comprised approximately equal numbers of WN virus-positive and -negative samples, as determined by MAC-ELISA. In addition, 377 samples submitted to the DVBID for arbovirus testing were analysed using the MIA and MAC-ELISA at the DVBID only. For the specimens tested at both the state and the DVBID laboratories, a correlation of results indicated that the technology is readily transferable between laboratories. The detection of IgM antibodies to WN virus was more consistent than detection of IgM antibodies to SLE virus. Some changes were made to the analysis software that resulted in an improved accuracy of diagnosis.
KW - antibodies
KW - antibody testing
KW - blood serum
KW - cerebrospinal fluid
KW - diagnostic techniques
KW - ELISA
KW - human diseases
KW - IgM
KW - immunoassay
KW - immunodiagnosis
KW - St Louis encephalitis
KW - viral diseases
KW - West Nile fever
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antibody detection
KW - antibody tests
KW - enzyme linked immunosorbent assay
KW - microspheres
KW - serological diagnosis
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073233550&site=ehost-live&scope=site
UR - email: ajj1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Genotoxicity of aristolochic acid: a review.
AU - Chen, T.
A2 - Fu, P. F.
T2 - Journal of Food and Drug Analysis
T3 - Special issue: Quality assurance and safety of herbal dietary supplements.
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
Y1 - 2007///
VL - 15
IS - 4
SP - 387
EP - 399
CY - Taipei; Taiwan
PB - National Laboratories of Foods and Drugs Department of Health, Executive Yuan
SN - 1021-9498
AD - Chen, T.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20083071082. Publication Type: Journal Article. Note: Special issue: Quality assurance and safety of herbal dietary supplements. Language: English. Number of References: 102 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Aristolochic acid (AA), a mixture of aristolochic acid I (AAI) and aristolochic acid II (AAII), is present in Aristolochiaceae plants, many of which are used as herbal folk remedies. Plants containing AA, however, can be nephrotoxic, genotoxic and carcinogenic in humans. AA has been also associated with the development of tumors in mice and rats. Therefore, plant products containing AA have been banned in many countries. Because quantitative cancer risk assessment is based upon an understanding of the chemical's mode-of-action, it is necessary to determine whether the chemical is a mutagenic carcinogen. In this review, we present the available information concerning the genotoxicity of AA and discuss the possible mechanisms for mutation induction by AA. The evidences indicate that AA is mutagenic and this activity is mediated mainly by the formation of AA-DNA adducts. Not only does AA induce genetic damage and mutations in bacteria, mammalian cells, Drosophila, and rodents, but it is also demonstrated to induce mutations in the target tissues of the model animals and oncogenes from human. Many evidences from genotoxicity tests also indicate that AA is a clastogenic agent that breaks DNA and results in chromosome damage and chromosome mutations. These results indicate that AA is a mutagenic carcinogen.
KW - adverse effects
KW - genotoxicity
KW - herbal drugs
KW - mutants
KW - mutations
KW - nontarget organisms
KW - reviews
KW - traditional Chinese medicines
KW - traditional medicines
KW - Aristolochiaceae
KW - Aristolochiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - adverse reactions
KW - herbal medicines
KW - non-target organisms
KW - non-target species
KW - nontarget species
KW - Non-food/Non-feed Plant Products (SS200)
KW - Toxicology and Poisoning (Wild Animals) (YY900) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083071082&site=ehost-live&scope=site
UR - email: tao.chen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements.
AU - Fu, P. P.
AU - Xia, Q.
AU - Chou, M. W.
AU - Lin Ge
A2 - Fu, P. F.
T2 - Journal of Food and Drug Analysis
T3 - Special issue: Quality assurance and safety of herbal dietary supplements.
JO - Journal of Food and Drug Analysis
JF - Journal of Food and Drug Analysis
Y1 - 2007///
VL - 15
IS - 4
SP - 400
EP - 415
CY - Taipei; Taiwan
PB - National Laboratories of Foods and Drugs Department of Health, Executive Yuan
SN - 1021-9498
AD - Fu, P. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083071067. Publication Type: Journal Article. Note: Special issue: Quality assurance and safety of herbal dietary supplements. Language: English. Number of References: 145 ref. Subject Subsets: Public Health; Aromatic & Medicinal Plants
N2 - Since the U.S. Congress passed the Dietary Supplement Health and Education Act (DSHEA) in 1994, herbal products, including herbal dietary supplements, represent the fastest growing segment of the vitamin, mineral supplements, and herbal products industry. To ensure consumer health protection, the quality and safety of raw herbal plants used for dietary supplement preparations have to be determined. To date, safety issues concerning the hepatotoxic and tumorigenic ingredients in many raw herbs and herbal dietary products are quite limited. Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic phytochemicals present in more than 6000 plants and have been detected in herbal plants and dietary supplements. In this review, the human exposure, metabolic activation leading to hepatototoxicity and tumorigenicity of the pyrrolizidine alkaloid-containing Chinese herbal plants, and analytical methods used to identify and quantify pyrrolizidine alkaloids in herbal plants and commercial samples are discussed. Suggestions for future research are provided.
KW - adverse effects
KW - analytical methods
KW - carcinogenesis
KW - food supplements
KW - herbal drugs
KW - pyrrolizidine alkaloids
KW - reviews
KW - toxicity
KW - traditional Chinese medicines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - analytical techniques
KW - herbal medicines
KW - Non-food/Non-feed Plant Products (SS200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083071067&site=ehost-live&scope=site
UR - email: peter.fu@fda.hhs.gov\linge@cuhk.edu.hk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Obesity, white blood cell counts, and platelet counts among police officers.
AU - Charles, L. E.
AU - Fekedulegn, D.
AU - McCall, T.
AU - Burchfiel, C. M.
AU - Andrew, M. E.
AU - Violanti, J. M.
JO - Obesity
JF - Obesity
Y1 - 2007///
VL - 15
IS - 11
SP - 2846
EP - 2854
CY - Silver Spring; USA
PB - North American Association for the Study of Obesity (NAASO)
SN - 1930-7381
AD - Charles, L. E.: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS L-4050, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20083011472. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Objective: To determine the association between several obesity indices (BMI, waist circumference, waist-to-hip and waist-to-height ratios, and abdominal height) and hematologic parameters [white blood cell (WBC) and platelet counts] among police officers. Research Methods and Procedures: The authors conducted this cross-sectional study among 104 randomly selected officers (41 women and 63 men) from the Buffalo, NY, Police Department. Anthropometric measures were performed by clinic staff, and fasting blood samples were drawn for complete blood counts. Pearson's correlation, Student's t tests, ANOVA, analysis of covariance, and linear regression were used to assess the associations. Results: Officers ranged in age from 26 to 61 years old and were predominantly white. Among women, current smokers had significantly higher WBC counts (7.4×103 cells/µL±1.4) than former (5.2×103 cells/µL±1.4) or never smokers (5.6×103 cells/µL±1.5) (p=0.002). Women had similar WBC counts but higher mean platelet counts than men (p=0.005). Among women, abdominal height was positively associated with platelet count after adjustment for depression (p for trend=0.039). Among women and men, a non-significant step-wise trend was observed between abdominal height and mean WBC counts before and after adjustment for smoking, race, and physical activity. No association was observed between obesity and platelet count among men. Discussion: Abdominal height was significantly associated with increased platelet counts among female officers. No significant associations were observed between obesity and WBC or platelet counts among male officers.
KW - anthropometric dimensions
KW - body mass index
KW - leukocyte count
KW - obesity
KW - occupational health
KW - platelet count
KW - sex differences
KW - New York
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anthropometric measurements
KW - cell count
KW - fatness
KW - United States of America
KW - Human Physiology and Biochemistry (VV050)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083011472&site=ehost-live&scope=site
UR - http://www.obesityresearch.org/cgi/content/abstract/15/11/2846
UR - email: lcharles@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - An indoor environmental quality investigation of the Fayette County (Pennsylvania) Courthouse.
AU - Martin, S. B., Jr.
AU - Coffey, C. C.
T2 - Indoor and Built Environment
JO - Indoor and Built Environment
JF - Indoor and Built Environment
Y1 - 2007///
VL - 16
IS - 5
SP - 456
EP - 464
CY - London; UK
PB - Sage Publications Ltd
SN - 1420-326X
AD - Martin, S. B., Jr.: Department of Health & Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20073237280. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 108-88-3. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation (HHE) investigation in the basement of the Fayette County Courthouse, Uniontown, Pennsylvania, USA. About 50 employees had reported a variety of health complaints including headaches, throat irritation, eye irritation, nausea, fatigue and nasal/sinus symptoms. Potential causes of the complaints included excessive mould/mildew, lack of air flow, odours and high dust levels. A number of locations showing signs of water incursion or leakage had mould growth. The air flow provided by the ventilation systems in most areas was inadequate, although the temperature, relative humidity and carbon dioxide levels largely met the published recommendations. The levels of common volatile organic compounds were all below the established exposure limits, and only toluene was found in concentrations above the established odour thresholds. It is concluded that the courthouse has a number of deficiencies, most notably in terms of ventilation, water leaks and general housekeeping. However, there are no solid links between the measured parameters and the reported health complaints or illnesses.
KW - air quality
KW - dust
KW - eye diseases
KW - fatigue
KW - headaches
KW - health hazards
KW - human diseases
KW - mildews
KW - moulds
KW - nausea
KW - occupational hazards
KW - occupational health
KW - odours
KW - organic compounds
KW - personnel
KW - respiratory diseases
KW - toluene
KW - ventilation
KW - volatile compounds
KW - Pennsylvania
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - lung diseases
KW - molds
KW - odors
KW - organic chemicals
KW - smells
KW - staff
KW - tiredness
KW - United States of America
KW - volatile constituents
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073237280&site=ehost-live&scope=site
UR - http://ibe.sagepub.com/
UR - email: SMartin1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of particulate matter air pollution on hospital admissions and medical visits for lung and heart disease in two southeast Idaho cities.
AU - Ulirsch, G. V.
AU - Ball, L. M.
AU - Kaye, W.
AU - Shy, C. M.
AU - Lee, C. V.
AU - Crawford-Brown, D.
AU - Symons, M.
AU - Holloway, T.
JO - Journal of Exposure Science and Environmental Epidemiology
JF - Journal of Exposure Science and Environmental Epidemiology
Y1 - 2007///
VL - 17
IS - 5
SP - 478
EP - 487
CY - New York; USA
PB - Nature America, Inc.
SN - 1559-0631
AD - Ulirsch, G. V.: Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease Registry, 1825 Century Center Blvd., Public Health Service, Atlanta, GA 30345, USA.
N1 - Accession Number: 20083106624. Publication Type: Journal Article. Language: English. Registry Number: 630-08-0, 10028-15-6. Subject Subsets: Public Health
N2 - Few, if any, published time series studies have evaluated the effects of particulate matter air exposures by combining hospital admissions with medical visit data for smaller populations. We investigated the relationship between daily particulate matter (<10 µm in aerometric diameter or PM10) exposures with admissions and medical visits (emergency room, urgent care, and family practice) for respiratory and cardiovascular disease in Pocatello and Chubbuck, Idaho (population about 60 000), from November 1994 through March 2000. Within generalized linear models, time, weather, influenza, and day-of-week effects were controlled. In single-pollutant models, respiratory disease admissions and visits increased (7.1-15.4% per 50 µg/m3 PM10) for each age group analysed, with the highest increases in two groups, children and especially the elderly. Statistical analyses suggest that the results probably did not occur by chance. Sensitivity analyses did not provide strong evidence that the respiratory disease effect estimates were sensitive to reasonable changes in the final degrees of freedom choice for time and weather effects. No strong evidence of confounding by NO2 and SO2 was found from results of multi-pollutant models. Ozone and carbon monoxide data were not available to include multi-pollutant models, but evidence suggests that they were not a problem. Unexpectedly, evidence of an association between PM10 with cardiovascular disease was not found, possibly due to the lifestyles of the mostly Mormon study population. Successful time series analyses can be performed on smaller populations if diverse, centralized databases are available. Hospitals that offer urgent or other primary care services may be a rich source of data for researchers. Using data that potentially represented a wide-range of disease severity, the findings provide evidence that evaluating only hospital admissions or emergency room visit effects may underestimate the overall morbidity due to acute particulate matter exposures. Further work is planned to test this conclusion.
KW - air pollution
KW - carbon monoxide
KW - cardiovascular diseases
KW - cardiovascular system
KW - children
KW - effects
KW - elderly
KW - health care
KW - heart
KW - heart diseases
KW - hospitals
KW - human diseases
KW - influenza
KW - lungs
KW - morbidity
KW - ozone
KW - pollution
KW - primary health care
KW - research workers
KW - respiratory diseases
KW - urban areas
KW - Idaho
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mountain States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - atmospheric pollution
KW - circulatory system
KW - coronary diseases
KW - elderly people
KW - environmental pollution
KW - flu
KW - lung diseases
KW - older adults
KW - practices
KW - research personnel
KW - researchers
KW - senior citizens
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Services (UU350)
KW - Demography (UU200)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083106624&site=ehost-live&scope=site
UR - http://www.nature.com/jes/journal/v17/n5/abs/7500542a.html
UR - email: gulirsch@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Update of US FDA's total diet study food list and diets.
AU - Egan, S. K.
AU - Bolger, P. M.
AU - Carrington, C. D.
JO - Journal of Exposure Science and Environmental Epidemiology
JF - Journal of Exposure Science and Environmental Epidemiology
Y1 - 2007///
VL - 17
IS - 6
SP - 573
EP - 582
CY - New York; USA
PB - Nature America, Inc.
SN - 1559-0631
AD - Egan, S. K.: HFS-301, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083106632. Publication Type: Journal Article. Language: English. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition
N2 - The US Food and Drug Administration's (FDA) Total Diet Study (TDS) has been conducted continuously since the early 1960s to measures levels of various pesticide residues, contaminants, and nutrients in foods and to estimate the dietary exposures to these compounds. Both the TDS food list and the consumption amounts used for estimating exposures are based on results of nationwide food consumption surveys, and they are updated periodically to reflect changes in food consumption patterns. The most recent update was completed in 2003 using the same methodology employed in the previous update (1990). The updated food list includes approximately the same number of foods (285) as the previous list (290). Although most (75%) foods are the same in both versions, the new list reflects trends in consumption of foods containing less fat. The updated diets reflect an increase in total food consumption, with most notable increases in consumption of grains and beverages. A case study comparing cadmium exposures calculated from both the 1990 and 2003 versions of the TDS demonstrated the potential impact of changes in both the food list and consumption amounts on TDS exposure estimates.
KW - beverages
KW - cadmium
KW - diet studies
KW - diets
KW - estimation
KW - food
KW - food consumption
KW - foods
KW - methodology
KW - nutrients
KW - pesticide residues
KW - pesticides
KW - residues
KW - surveys
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - drinks
KW - methods
KW - Other Produce (QQ070)
KW - Diet Studies (VV110)
KW - Human Nutrition (General) (VV100)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083106632&site=ehost-live&scope=site
UR - http://www.nature.com/jes/journal/v17/n6/abs/7500554a.html
UR - email: Katie.Egan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mammalian iron metabolism.
AU - Valerio, L. G., Jr.
JO - Toxicology Mechanisms and Methods
JF - Toxicology Mechanisms and Methods
Y1 - 2007///
VL - 17
IS - 9
SP - 497
EP - 517
CY - New York; USA
PB - Informa Healthcare
SN - 1537-6524
AD - Valerio, L. G., Jr.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition,Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, Maryland, USA.
N1 - Accession Number: 20093064794. Publication Type: Journal Article. Language: English. Number of References: 240 ref. Registry Number: 7439-89-6, 11096-37-0. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Iron is an essential transition metal for mammalian cellular and tissue viability. It is critical to supplying oxygen through heme, the mitochondrial respiratory chain, and enzymes such as ribonucleotide reductase. Mammalian organisms have evolved with the means of regulating the metabolism of iron, because if left unregulated, the resulting excess amounts of iron may induce chronic toxicities affecting multiple organ systems. Several homeostatic mechanisms exist to control the amount of intestinal dietary iron uptake, cellular iron uptake, distribution, and export. Within these processes, numerous molecular participants have been identified because of advancements in basic cell biology and efforts in disease-based research of iron storage abnormalities. For example, dietary iron uptake across the intestinal duodenal mucosa is mediated by an intramembrane divalent metal transporter 1 (DMT1), and cellular iron efflux involves ferroportin, the only known iron exporter. In addition to duodenal enterocytes, ferroportin is present in other cell types, and exports iron into plasma. Ferroportin was recently discovered to be regulated by the expression of the circulating hormone hepcidin, a small peptide synthesized in hepatocytes. These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload. Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1). In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism. From a toxicological standpoint, posttranscriptional regulation of these genes aids in the sequestration, control, and hence prevention of cytotoxic effects from free-floating nontransferrin-bound iron. Given the importance of dietary iron in normal physiology, its potential to induce chronic toxicity, and recent discoveries in the regulation of human iron metabolism by hepcidin, this review will address the regulatory mechanisms of normal iron metabolism in mammals with emphasis on dietary exposure. It is the goal of this review that this information may provide in a concise format our current understanding of major pathways and mechanisms involved in mammalian iron metabolism, which is a basis for control of iron toxicity. Such a discussion is intended to facilitate the identification of deficiencies so that future metabolic or toxicological studies may be appropriately focused. A better knowledge of iron metabolism from normal to pathophysiological conditions will ultimately broaden the spectrum of the usefulness of this information in biomedical and toxicological sciences for improving and protecting human health.
KW - biochemistry
KW - iron
KW - metabolism
KW - physiology
KW - reviews
KW - transferrin
KW - mammals
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - ferroportin
KW - iron metabolism
KW - Animal Nutrition (Physiology) (LL510)
KW - Human Physiology and Biochemistry (VV050)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093064794&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a787705534~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of ethyl carbamate in Korean soy sauce using high-performance liquid chromatography with fluorescence detection or tandem mass spectrometry and gas chromatography with mass spectrometry.
AU - Park SungKug
AU - Kim CheongTae
AU - Lee JooWon
AU - Jhee OkHwa
AU - Om AeSeon
AU - Kang JuSeop
AU - Moon TaeWha
JO - Food Control
JF - Food Control
Y1 - 2007///
VL - 18
IS - 8
SP - 975
EP - 982
CY - Oxford; UK
PB - Elsevier
SN - 0956-7135
AD - Park SungKug: Center for Food Standard Evaluation, Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20073084101. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 2321-07-5, 518-47-8. Subject Subsets: Human Nutrition; Soyabeans
N2 - A specific, sensitive procedure involving high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) was developed and compared to other analytical methods for quantification of ethyl carbamate (EC) in Korean soy sauce products. HPLC with a fluorescence detector was not applicable for monitoring trace amounts of EC in soy sauce due to its low detection limit (20 ppb). The use of gas chromatography (GC) coupled to MS could be applied to soy sauce, but it was not as simple and fast as HPLC/MS/MS. The GC/MS procedure exhibited excellent linearity over the concentration range of 10-200 ppb with a 0.5 ppb limit of detection (LOD) and 82.7±3.1% recovery. A procedure involving HPLC/MS/MS with multiple reaction monitoring was developed. The characteristic transitions of m/z 90 -> 62 for EC as well as m/z 104 -> 62 for propyl carbamate (PC) as the internal standard were monitored. Good linearity was obtained both in the range from 10 to 100 ppb and in the range from 0.1 to 20 ppb with a LOD of 0.05 ppb. The average recovery was 92.2±1.7%. The applicability of the GC/MS and developed HPLC/MS/MS methods was demonstrated by detection of EC in 12 kinds of commercial Korean soy sauce products at levels of 0.5 and 0.1 ppb, respectively. The new HPLC/MS/MS method provided greater sensitivity with a simpler and shorter confirmatory analysis than the GC/MS method.
KW - analytical methods
KW - fluorescein
KW - GC-MS
KW - HPLC
KW - mass spectrometry
KW - soya sauce
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - analytical techniques
KW - gas chromatography-mass spectrometry
KW - high performance liquid chromatography
KW - South Korea
KW - soy sauce
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073084101&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09567135
UR - email: twmoon@snu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Centrin1 is required for organelle segregation and cytokinesis in Trypanosoma brucei.
AU - Selvapandiyan, A.
AU - Kumar, P.
AU - Morris, J. C.
AU - Salisbury, J. L.
AU - Wang, C. C.
AU - Nakhasi, H. L.
T2 - Molecular Biology of the Cell
JO - Molecular Biology of the Cell
JF - Molecular Biology of the Cell
Y1 - 2007///
VL - 18
IS - 9
SP - 3290
EP - 3301
CY - Bethesda; USA
PB - American Society for Cell Biology
SN - 1059-1524
AD - Selvapandiyan, A.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073224312. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Protozoology
N2 - Centrin is a calcium-binding centrosome/basal body-associated protein involved in duplication and segregation of these organelles in eukaryotes. We had shown that disruption of one of the centrin genes (centrin1) in Leishmania amastigotes resulted in failure of both basal body duplication and cytokinesis. Here, we undertook to define the role of centrin1 (TbCen1) in the duplication and segregation of basal body and its associated organelles kinetoplast and Golgi, as well as its role in cytokinesis of the procyclic form of Trypanosoma brucei by depleting its protein using RNA inhibition methodology. TbCen1-depleted cells showed significant reduction in growth compared with control cells. Morphological analysis of these cells showed they were large and pleomorphic with multiple detached flagella. Both immunofluorescence assays using organelle-specific antibodies and electron microscopic analysis showed that TbCen1-deficient cells contained multiple basal bodies, kinetoplasts, Golgi, and nuclei. These multiple organelles were, however, closely clustered together, indicating duplication without segregation in the absence of centrin. This failure in organelle segregation may be the likely cause of inhibition of cytokinesis, suggesting for the first time a new and unique role for centrin in the segregation of organelles without affecting their multiplication in the procyclic form of T. brucei.
KW - biochemistry
KW - cell division
KW - centrosomes
KW - Golgi apparatus
KW - kinetoplast DNA
KW - molecular biology
KW - nuclei
KW - Trypanosoma brucei
KW - Trypanosoma
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - cell nuclei
KW - karyokinesis
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073224312&site=ehost-live&scope=site
UR - http://www.molbiolcell.org
UR - email: hira.nakhasi@fda.hhs.gov\angamuthu.selvapandiyan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic lymphocytic leukemia radiogenicity: a systematic review.
AU - Silver, S. R.
AU - Hiratzka, S. L.
AU - Schubauer-Berigan, M. K.
AU - Daniels, R. D.
JO - Cancer Causes & Control
JF - Cancer Causes & Control
Y1 - 2007///
VL - 18
IS - 10
SP - 1077
EP - 1093
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0957-5243
AD - Silver, S. R.: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), 5555 Ridge, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073280718. Publication Type: Journal Article. Language: English. Number of References: 119 ref. Subject Subsets: Public Health
N2 - Objective: Chronic lymphocytic leukemia (CLL) is generally considered to be non-radiogenic and is excluded from several programs that compensate workers for illnesses resulting from occupational exposures. Questions about whether this exclusion is justified prompted a Congressional mandate to the National Institute for Occupational Safety and Health (NIOSH) to, further, examine the radiogenicity of CLL. This study revisits the question of CLL radiogenicity by examining epidemiologic evidence from occupationally and medically-exposed populations. Methods: A systematic review of radiation-exposed cohorts was conducted to investigate the association between radiation and CLL. Exploratory power calculations for a pooled occupational study were performed to examine the feasibility of assessing CLL radiogenicity epidemiologically. Results: There is a bias against reporting CLL results, because of the disease's presumed non-radiogenicity. In medical cohort studies that provide risk estimates for CLL, risk is elevated, though non-significantly, in almost all studies with more than 15 years average follow-up. The results of occupational studies are less consistent. Conclusions: Studies with adequate follow-up time and power are needed to better understand CLL radiogenicity. Power analyses show that a pooled study might detect risk on the order of radiation induced non-CLL leukemia, but is unlikely to detect smaller risks.
KW - carcinogens
KW - exposure
KW - human diseases
KW - leukaemia
KW - neoplasms
KW - occupational hazards
KW - reviews
KW - risk assessment
KW - risk factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - blood cancer
KW - cancers
KW - leucaemia
KW - leukemia
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073280718&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=100150
UR - email: ssilver@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An approach to risk assessment for TiO2.
AU - Dankovic, D.
AU - Kuempel, E.
AU - Wheeler, M.
T3 - Special Issue: Linking health effects to components and size of PM and PM sources.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2007///
VL - 19
IS - Supl. 1
SP - 205
EP - 212
CY - New York; USA
PB - Informa Healthcare
SN - 0895-8378
AD - Dankovic, D.: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
N1 - Accession Number: 20083235962. Publication Type: Journal Article. Note: Special Issue: Linking health effects to components and size of PM and PM sources. Language: English. Number of References: 44 ref. Registry Number: 13463-67-7. Subject Subsets: Public Health
N2 - Titanium dioxide (TiO2) is a poorly soluble, low-toxicity (PSLT) particle. Fine TiO2 (<2.5 µm) has been shown to produce lung tumors in rats exposed to 250 mg/m3, and ultrafine TiO2 (<0.1 µm diameter) has been shown to produce lung tumors in rats at 10 mg/m3. We have evaluated the rat dose-response data and conducted a quantitative risk assessment for TiO2. Preliminary conclusions are: (1) Fine and ultrafine TiO2 and other PSLT particles show a consistent dose-response relationship when dose is expressed as particle surface area; (2) the mechanism of TiO2 tumor induction in rats appears to be a secondary genotoxic mechanism associated with persistent inflammation; and (3) the inflammatory response shows evidence of a nonzero threshold. Risk estimates for TiO2 depend on both the dosimetric approach and the statistical model that is used. Using 7 different dose-response models in the U.S. Environmental Protection Agency (EPA) benchmark dose software, the maximum likelihood estimate (MLE) rat lung dose associated with a 1 per 1000 excess risk ranges from 0.0076 to 0.28 m2/g-lung of particle surface area, with 95% lower confidence limits (LCL) of 0.0059 and 0.042, respectively. Using the ICRP particle deposition and clearance model, estimated human occupational exposures yielding equivalent lung burdens range from approximately 1 to 40 mg/m3 (MLE) for fine TiO2, with 95% LCL approximately 0.7-6 mg/m3. Estimates using an interstitial sequestration lung model are about one-half as large. Bayesian model averaging techniques are now being explored as a method for combining the various estimates into a single estimate, with a confidence interval expressing model uncertainty.
KW - air pollutants
KW - animal models
KW - exposure
KW - human diseases
KW - laboratory animals
KW - lung cancer
KW - neoplasms
KW - respiratory diseases
KW - risk assessment
KW - risk factors
KW - titanium dioxide
KW - toxicity
KW - toxicology
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - lung diseases
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083235962&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a782018069~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dioxin and furan contamination of deodorizer distillates and natural vitamin E supplements.
AU - Halbert, M. K.
AU - Archer, J. C.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2007///
VL - 20
IS - 6
SP - 506
EP - 514
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Halbert, M. K.: Food and Drug Administration, Arkansas Regional Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073159483. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 1406-18-4. Subject Subsets: Human Nutrition
N2 - Thirty-five samples of vitamin E supplement softgels, obtained from store shelves, were analyzed for 17 dioxin and furan congeners. Of these samples, 14 were identified as natural vitamin E, containing D-α-tocopherol, as well as lesser amounts of β-, α-, and δ-tocopherols, and the remaining 21 were labeled as synthetic vitamin E, containing a mixture of D- and L-a-tocopherol. The supplements were collected during the years of 2002 and 2004. The seven natural vitamin E supplements collected in 2002 were found to contain significant quantities of dioxins and furans, with an average total toxic equivalence (TEQ) of 0.79 pg/g, compared to 0.10 g/g for the 2004 natural vitamin E supplements. The 21 synthetic vitamin E supplements collected during the same time period showed little or no contamination, with an average TEQ of 0.057 pg/g. Eight samples of deodorizer distillate, from which natural vitamin E is derived, were also collected and analyzed. The distillates exhibit an overall congener pattern similar to that found in the natural vitamin E, but at a much higher average TEQ of 3.4 pg/g. This suggests the possibility of carryover of contamination to the vitamin E samples from the deodorizer distillate during the extraction process. The natural vitamin E supplements collected in 2004 have much lower levels of contamination, suggesting that improved extraction processes may be in use, effectively reducing contamination.
KW - deodorizing
KW - dioxins
KW - food contamination
KW - food supplements
KW - furans
KW - vitamin E
KW - vitamin supplements
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073159483&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: mary.halbert@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients.
AU - Naeger, L. K.
AU - Struble, K. A.
JO - AIDS
JF - AIDS
Y1 - 2007///
VL - 21
IS - 2
SP - 179
EP - 185
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Naeger, L. K.: Division of Antiviral Products, Center for New Drug Evaluation, Food and Drug Administration, 10903 New Hampshire Avenue, Building #22, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20073034757. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 174484-41-4. Subject Subsets: Public Health; Tropical Diseases
N2 - Objective: To assess the resistance profile of tipranavir. Methods: Resistance analyses were performed on Boëhringer Ingelheim-sponsored studies examining the safety and efficacy of tipranavir in highly treatment-experienced individuals at 24 weeks. Virologic response rates based on the presence of baseline primary protease inhibitor mutations and based on baseline tipranavir susceptibility were evaluated, and the development of protease mutations during treatment with tipranavir was analyzed. Results: Virologic response rates in tipranavir-treated individuals were reduced when isolates with substitutions at amino acid positions I13, V32, M36, I47, Q58, D60 V82 or I84 were present at baseline. In addition, virologic response rates to tipranavir decreased when the number of baseline protease inhibitor (PI) mutations was five or more. Individuals who received tipranavir without concomitant enfurvitide and had five or more baseline PI mutations group began to lose antiviral response between weeks 4 and 8. However, individuals taking enfuvirtide with tipranavir were able to achieve greater than 1.5 log10 reductions in viral load from baseline out to 24 weeks even if they had five or more baseline PI mutations. Virologic response rates to tipranavir decreased when the baseline phenotype for tipranavir had a greater than three-fold shift in the 50% effective concentration (EC50) from reference. The most common protease mutations that developed in tipranavir-treated individuals who experienced virologic failure were L10I/V/S, I13V, L33V/I/F, M36V/I/L V82T, V82L, and I84V. The resistance profile in treatment-naive individuals was not characterized. Conclusions: Baseline genotypic and phenotypic data provide valuable information on the likelihood of a virologic response to tipranavir.
KW - antiviral agents
KW - drug resistance
KW - drug therapy
KW - HIV-1 infections
KW - human diseases
KW - mutations
KW - proteinase inhibitors
KW - resistance mechanisms
KW - tipranavir
KW - Australia
KW - Canada
KW - Europe
KW - Latin America
KW - USA
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - North America
KW - America
KW - chemotherapy
KW - enfuvirtide
KW - Human immunodeficiency virus type 1
KW - protease inhibitors
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073034757&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
UR - email: lisa.naeger@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System.
AU - Chan-Tack, K. M.
AU - Truffa, M. M.
AU - Struble, K. A.
AU - Birnkrant, D. B.
JO - AIDS
JF - AIDS
Y1 - 2007///
VL - 21
IS - 9
SP - 1215
EP - 1218
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Chan-Tack, K. M.: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20073140080. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Registry Number: 198904-31-3. Subject Subsets: Public Health
N2 - The risk of nephrolithiasis associated with atazanavir is not well characterized. The US Food and Drug Administration's Adverse Event Reporting System was searched for reports of nephrolithiasis in HIV-infected patients taking an atazanavir-based regimen. Thirty cases were identified. Many patients required hospitalization for management, including lithotripsy, ureteral stent insertion, or endoscopic stone removal. Some cases of nephrolithiasis resulted in atazanavir discontinuation. Healthcare professionals and patients should be informed that nephrolithiasis is a possible adverse event with atazanavir.
KW - adverse effects
KW - antiviral agents
KW - atazanavir
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - nephrolithiasis
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073140080&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Drug use patterns and trends in rural communities.
AU - Gfroerer, J. C.
AU - Larson, S. L.
AU - Colliver, J. D.
A2 - Clayton, R. R.
A2 - McBride, D.
A2 - Roberts, L. W.
A2 - Hartsock, P.
JO - Journal of Rural Health
JF - Journal of Rural Health
Y1 - 2007///
VL - 23
IS - s1
SP - 10
EP - 15
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0890-765X
AD - Gfroerer, J. C.: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1015, Rockville, MD 20857, USA.
N1 - Accession Number: 20083124934. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Context and Purpose: This study examines the prevalence of tobacco, alcohol, and illicit drug use among adolescents and adults in 3 types of counties: "rural" (nonmetropolitan counties with urban population less than 20 000), "urbanized nonmetropolitan" (nonmetropolitan counties with urban population 20 000 or higher), and "metropolitan" (counties in metropolitan areas). Methods: Data from the 2002-2004 National Surveys on Drug Use and Health are used to compare residents of the 3 county types. Descriptive findings and a multivariate model of marijuana use among adolescents are presented by county type. Findings: Past year illicit drug use is generally similar among adolescents in rural, urbanized nonmetropolitan, and metropolitan counties, except that Ecstasy use is higher among youth in metropolitan and urbanized nonmetropolitan counties than rural counties, while rural youth have a higher prevalence of stimulant and methamphetamine use than metropolitan youth. Gender, race/ethnicity, and family income functioned differentially across the 3 county types as predictors of youth marijuana use during the past year. Rural adults had generally lower rates of illicit drug use than metropolitan adults, but adults in rural and urbanized nonmetropolitan areas had higher rates of methamphetamine use than those in metropolitan areas. Rural youth had a higher prevalence of past month use of tobacco and alcohol. Rural adults had higher rates of tobacco use but lower rates of alcohol use. Conclusions: This study dispels the notion that substance abuse is only an urban problem and provides information useful in developing and implementing interventions that consider the unique characteristics of rural residents.
KW - adolescents
KW - adults
KW - alcohol intake
KW - children
KW - controlled substances
KW - drug abuse
KW - drug users
KW - ethnic groups
KW - hemp
KW - household income
KW - rural areas
KW - rural communities
KW - sex differences
KW - socioeconomic status
KW - stimulants
KW - substance abuse
KW - tobacco smoking
KW - trends
KW - urban areas
KW - USA
KW - Cannabis sativa
KW - man
KW - Cannabis
KW - Cannabidaceae
KW - Urticales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - drug abusers
KW - drug use
KW - drugs (controlled substances)
KW - methamphetamine
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083124934&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1748-0361.2007.00118.x
UR - email: Joe.Gfroerer@samhsa.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A modern view of excipient effects on bioequivalence: case study of sorbitol.
AU - Chen, M. L.
AU - Straughn, A. B.
AU - Sadrieh, N.
AU - Meyer, M.
AU - Faustino, P. J.
AU - Ciavarella, A. B.
AU - Meibohm, B.
AU - Yates, C. R.
AU - Hussain, A. S.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2007///
VL - 24
IS - 1
SP - 73
EP - 80
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0724-8741
AD - Chen, M. L.: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue Building 21, Rm. 3644, Silver Spring, MD 20993-0002, USA.
N1 - Accession Number: 20073059737. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 37350-58-6, 50-70-4, 57-50-1. Subject Subsets: Sugar Industry
N2 - Purpose: To examine the effect of common excipients such as sugars (sorbitol versus sucrose) on bioequivalence between pharmaceutical formulations, using ranitidine and metoprolol as model drugs. Methods: Two single-dose, replicated, crossover studies were first conducted in healthy volunteers (N=20 each) to compare the effect of 5 g of sorbitol and sucrose on bioequivalence of 150 mg ranitidine or 50 mg metoprolol in aqueous solution, followed by a single-dose, nonreplicated, crossover study (N=24) to determine the threshold of sorbitol effect on bioequivalence of 150 mg ranitidine in solution. Results: Ranitidine Cmax and AUC(0-∞) were decreased by ~50% and 45%, respectively, in the presence of sorbitol versus sucrose. Similarly, sorbitol reduced metoprolol Cmax by 23% but had no significant effect on AUC(0-∞). An appreciable subject-by-formulation interaction was found for ranitidine Cmax and AUC(0-∞), as well as metoprolol Cmax. Sorbitol decreased the systemic exposure of ranitidine in a dose-dependent manner and affected bioequivalence at a level of 1.25 g or greater. Conclusions: As exemplified by sorbitol, some common excipients have unexpected effect on bioavailability/bioequivalence, depending on the pharmacokinetic characteristics of the drug, as well as the type and amount of the excipient present in the formulation. More research is warranted to examine other 'common' excipients that may have unintended influence on bioavailability/bioequivalence.
KW - antacids
KW - bioavailability
KW - drug formulations
KW - metoprolol
KW - pharmacokinetics
KW - pharmacology
KW - sorbitol
KW - sucrose
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ranitidine
KW - saccharose
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073059737&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=105282
UR - email: meiling.chen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and molecular characterization of Salmonella spp. from unpasteurized orange juices and identification of new serotype Salmonella strain S. enterica serovar Tempe.
AU - Khan, A. A.
AU - Melvin, C. D.
AU - Dagdag, E. B.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2007///
VL - 24
IS - 5
SP - 539
EP - 543
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Khan, A. A.: Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073144594. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health; Soyabeans; Human Nutrition
N2 - Several Salmonella enterica serotypes were isolated from unpasteurized orange juice samples analysed as a follow-up to an outbreak in 1999 of S. enterica serotype Muenchen in the Pacific Northwest regions of United States. Eleven S. enterica strains were serotyped and identified as S. enterica serotype Muenchen (2), S. enterica serotype Hidalgo (2), S. enterica serotype Alamo (1), S. enterica serotype Gaminera (2), S. enterica serotype Javiana (2) and a new serotyped strain S. enterica serotype Tempe (2). The identity of the new serotype S. enterica serovar Tempe serotype 30:b:1,7:z33 was confirmed by the National Salmonella Reference Laboratory at NCID/CDC, Atlanta. These strains were sensitive to ampicillin, chloramphenicol, kanamycin, tetracycline, streptomycin and sulfisoxazole antibiotics. Isolates were screened for invasion (invA) and virulence (spvC) genes using specific primers for these two genes by polymerase chain reaction. All strains were positive for invA gene giving 321-bp fragment, however negative to virulence spvC gene. For pulsed-field gel electrophoresis (PFGE) analysis, Salmonella strain plugs were made and digested with XbaI and subjected to 18-h electrophoresis. The PFGE patterns were different for each S. enterica serotypes suggesting the several origins of contamination in outbreak. S. enterica serotype.
KW - food contamination
KW - food poisoning
KW - foodborne diseases
KW - genes
KW - human diseases
KW - microbial contamination
KW - molecular genetics
KW - orange juice
KW - outbreaks
KW - phylogenetics
KW - salmonellosis
KW - strain differences
KW - strains
KW - USA
KW - man
KW - Salmonella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - biochemical genetics
KW - food contaminants
KW - Salmonella infections
KW - Salmonella tempe
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073144594&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: Ashraf.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US FDA's revised consumption factor for polystyrene used in food-contact applications.
AU - Cassidy, K.
AU - Elyashiv-Barad, S.
JO - Food Additives and Contaminants
JF - Food Additives and Contaminants
Y1 - 2007///
VL - 24
IS - 9
SP - 1026
EP - 1031
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Cassidy, K.: Division of Food Contact Notifications, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA.
N1 - Accession Number: 20073218599. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 9003-53-6.
N2 - US FDA's continual effort to evaluate the safety of food-contact materials includes periodically re-examining our established packaging factors, such as consumption and food-type distribution factors. The use of polystyrene in food-contact and disposable food-packaging applications has expanded and is expected to continue to increase in the future. Therefore, it is important to revise the polystyrene consumption factor to account for increases in consumer exposure to substances migrating from styrenic food packaging. The currently used consumption factor for polystyrene is 0.1, which is based on market data collected around 1980. US FDA has revised the polystyrene consumption factor utilizing three different sources of market data. Using consumption and population data, US FDA calculated a new consumption factor of 0.14 for polystyrene. This consumption factor has been further subdivided to allow for the refinement of exposure estimates for uses limited to specific subcategories of polystyrene packaging.
KW - food consumption
KW - food packaging
KW - food safety
KW - methodology
KW - packaging materials
KW - polystyrenes
KW - methods
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073218599&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: sharon.elyashiv-barad@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Animal cloning and the FDA - the risk assessment paradigm under public scrutiny.
AU - Rudenko, L.
AU - Matheson, J. C.
AU - Sundlof, S. F.
T2 - Nature Biotechnology
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2007///
VL - 25
IS - 1
SP - 39
EP - 43
CY - New York; USA
PB - Nature Publishing Group
SN - 1087-0156
AD - Rudenko, L.: Center for Veterinary Medicine, US Food and Drug Administration, Department of Health and Human Services, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20083154734. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Veterinary Science; Veterinary Science; Dairy Science; Agricultural Biotechnology; Animal Breeding
N2 - This article discusses the risk assessment process undertaken by the US Food and Drug Administration (FDA) of the safety of dairy and meat products from animals produced by somatic cell nuclear transfer (SCNT). The assessment involved the analysis of food composition and potential hazards to the health of the cloned animals during development. It was shown that SCNT poses no risks to animal health or consumption of food from clones. However, the moratorium on food and feed from cloned animals and their progeny will not be lifted until the completion of the entire risk assessment process.
KW - animal breeding
KW - animal cloning
KW - animal health
KW - clones
KW - domestic animals
KW - food safety
KW - livestock
KW - meat
KW - meat production
KW - meat products
KW - milk
KW - milk production
KW - milk products
KW - organizations
KW - regulations
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dairy products
KW - nuclear transfer
KW - rules
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Laws and Regulations (DD500)
KW - Dairy Animals (LL110)
KW - Meat Producing Animals (LL120)
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Animal Reproduction and Embryology (LL250) (New March 2000)
KW - Animal Health and Hygiene (General) (LL800)
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Cell, Tissue and Embryo Manipulation (WW300) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083154734&site=ehost-live&scope=site
UR - http://www.nature.com/nbt/
UR - email: larisa.rudenko@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prospective immunization of the endangered California condors (Gymnogyps californianus) protects this species from lethal West Nile virus infection.
AU - Chang, G. J. J.
AU - Davis, B. S.
AU - Stringfield, C.
AU - Lutz, C.
JO - Vaccine
JF - Vaccine
Y1 - 2007///
VL - 25
IS - 12
SP - 2325
EP - 2330
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Chang, G. J. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Disease, Center for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, 3150 Rampart Road, CDC-Foothills Campus, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20073049502. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Veterinary Science
N2 - West Nile virus (WNV) has caused significant morbidity and mortality in humans, mammals, and both native and exotic birds in North America since its emergence in New York City in 1999 and its subsequent spread westward. Prior to the arrival of WNV to the western United States, prospective vaccination was conducted for the entire population of endangered California condors, both in captivity and in the wild. Here we show that this vaccine is safe for condors, stimulates protective immunity in adults, nestlings, and newly hatched chicks. Most importantly, we demonstrate protection of captive birds exposed to naturally circulating WNV during the 2004 transmission season. The prospective vaccination of the entire population of California condors before the arrival of WNV has thus potentially saved this endangered species from subsequent lethal WNV encephalitis, and possible extinction.
KW - immunization
KW - vaccination
KW - West Nile fever
KW - wild animals
KW - wild birds
KW - USA
KW - birds
KW - Gymnogyps californianus
KW - West Nile virus
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Gymnogyps
KW - Cathartidae
KW - Falconiformes
KW - birds
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073049502&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of strategies to successfully vaccinate infants in developing countries against enterotoxigenic E. coli (ETEC) disease.
AU - Walker, R. I.
AU - Steele, D.
AU - Aguado, T.
JO - Vaccine
JF - Vaccine
Y1 - 2007///
VL - 25
IS - 14
SP - 2545
EP - 2566
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Walker, R. I.: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20851-1448, USA.
N1 - Accession Number: 20073069665. Publication Type: Journal Article. Corporate Author: Ad Hoc ETEC Technical Expert Committee Language: English. Number of References: 143 ref. Subject Subsets: Tropical Diseases
N2 - Enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause of diarrhoea in the world, annually affecting up to 400,000,000 children under 5 years of age living in developing countries (DCs). Although ETEC possesses numerous antigens, the relatively conserved colonization factor (CF) antigens and the heat labile enterotoxin (LT) have been associated with protection and most vaccine candidates have exploited these antigens. A safe and effective vaccine against ETEC is a feasible goal as supported by the acquisition of protective immunity. The success of an ETEC vaccine targeting infants and children in DCs will depend on a combination of maximally antigenic vaccine preparations and regimens for their delivery which will produce optimal immune responses to these antigens. Vaccine candidates having a high priority for accelerated development and clinical testing for eventual use in infants would include inactivated ETEC or Shigella hybrids expressing ETEC antigens as well as attenuated ETEC strains which express the major CF antigens and LT toxin B-subunit, as well as attenuated Shigella, Vibrio cholerae and Salmonella typhi hybrids engineered to deliver antigens of ETEC. Candidates for an ETEC vaccine would have to meet the minimal requirement of providing at least 50% protection against severe disease in DCs during the first 2 years of life. The critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded and focused effort to bring it to realization. However, a Product Development Partnership to overcome this hurdle could accelerate the time lines towards when control of ETEC disease in DCs is substantially closer.
KW - bacterial diseases
KW - candidate vaccines
KW - diarrhoea
KW - human diseases
KW - immunization
KW - infants
KW - reviews
KW - vaccination
KW - vaccine development
KW - Developing Countries
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - diarrhea
KW - E. coli
KW - immune sensitization
KW - scouring
KW - Third World
KW - Underdeveloped Countries
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073069665&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: walkerri@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of a targeted hepatitis B vaccination program in Amsterdam, The Netherlands.
AU - Houdt, R. van
AU - Sonder, G. J. B.
AU - Dukers, N. H. T. M.
AU - Bovee, L. P. M. J.
AU - Hoek, A. van den
AU - Coutinho, R. A.
AU - Bruisten, S. M.
JO - Vaccine
JF - Vaccine
Y1 - 2007///
VL - 25
IS - 14
SP - 2698
EP - 2705
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Houdt, R. van: GGD, Public Health Service, Department of Infectious Diseases, Amsterdam, Netherlands.
N1 - Accession Number: 20073069663. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - To evaluate hepatitis B virus (HBV) risk group vaccination in Amsterdam, which started in 1998, we examined 342 reported acute HBV-cases and sequenced 85 DNA isolates. The reported number of cases declined from 214 in 1992-1997 to 128 in 1998-2003, due to a decline in injecting drug users (IDU) and their heterosexual partners. Phylogenetic analyses showed that after 1998, the IDU cluster nearly disappeared, probably due to a decline in injecting. Acute HBV remained stable among men having sex with men; given their increased sexual risk behavior, vaccination has probably prevented an increase in their acute infections. Currently, 48-72% of the people who should be included in the program are still susceptible to HBV. Part of this study has been Presented at the 2005 Annual Meeting of the European Association for the Study of Liver in Paris (415), France and at the 2005 Biennial Meeting of the International Society for Sexual Transmitted Diseases in Amsterdam, The Netherlands (TP-029).
KW - hepatitis B
KW - homosexuality
KW - human diseases
KW - immunization
KW - immunization programmes
KW - injecting drug users
KW - liver diseases
KW - risk groups
KW - vaccination
KW - viral hepatitis
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - homosexuals
KW - i.v. drug abusers
KW - i.v. drug users
KW - immune sensitization
KW - immunization programs
KW - intravenous drug users
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073069663&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: rvhoudt@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Safety review of the purified chick embryo cell rabies vaccine: data from the Vaccine Adverse Event Reporting System (VAERS), 1997-2005.
AU - Dobardzic, A.
AU - Izurieta, H.
AU - Woo, E. J.
AU - Iskander, J.
AU - Shadomy, S.
AU - Rupprecht, C.
AU - Ball, R.
AU - Braun, M. M.
JO - Vaccine
JF - Vaccine
Y1 - 2007///
VL - 25
IS - 21
SP - 4244
EP - 4251
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Dobardzic, A.: Food and Drug Administration, Center for Biologies Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20073102558. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - On October 20, 1997, the U.S. Food and Drug Administration (FDA) licensed Purified Chick Embryo Cell (PCEC, RabAvert®) vaccine against rabies in humans following clinical trials demonstrating safety and efficacy. From October 1997 through December 2005, the Vaccine Adverse Event Reporting System (VAERS) received 336 reports of adverse events (AEs) following vaccination with PCEC vaccine in the U.S.; there were no death reports. Serious events, including 20 hospitalizations and 13 neurological events, were described in 24 (7%) reports. There was no pattern among the 13 neurological AEs suggesting a plausible relationship to vaccination. A total of 20 AEs, 3 serious, were classified as possible anaphylaxis. There were 312 non-serious AEs (93%). Nineteen reports (6%) described that the vaccination series was discontinued because of non-serious AEs. Most reported AEs are non-serious and consistent with pre-licensure safety data. The rabies risk must be carefully considered before vaccine discontinuation.
KW - adverse effects
KW - human diseases
KW - immunization
KW - rabies
KW - safety
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Rabies virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073102558&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: azra.dobardzic@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Thrombocytopenia: case definition and guidelines for collection, analysis, and presentation of immunization safety data.
AU - Wise, R. P.
AU - Bonhoeffer, J.
AU - Beeler, J.
AU - Donato, H.
AU - Downie, P.
AU - Matthews, D.
AU - Pool, V.
AU - Riise-Bergsaker, M.
AU - Tapiainen, T.
AU - Varricchio, F.
T2 - Vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2007///
VL - 25
IS - 31
SP - 5717
EP - 5724
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Wise, R. P.: Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20073161298. Publication Type: Journal Article. Corporate Author: Switzerland, The Brighton Collaboration Thrombocytopenia Working Group Language: English. Number of References: 53 ref. Subject Subsets: Public Health
KW - clinical aspects
KW - data collection
KW - guidelines
KW - human diseases
KW - immunization
KW - safety
KW - thrombocytopenia
KW - vaccination
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clinical picture
KW - data logging
KW - immune sensitization
KW - recommendations
KW - Host Resistance and Immunity (HH600)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161298&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: secretariat@brightoncollaboration.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perinatal hepatitis B transmission and vaccination timing in a managed care cohort: assessment of the temporary delay in newborn hepatitis B vaccination due to thimerosal content.
AU - Chang, S.
AU - Begier, E. M.
AU - Schech, S. D.
AU - Venus, P.
AU - Shatin, D.
AU - Braun, M. M.
AU - Ball, R.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2007///
VL - 26
IS - 4
SP - 329
EP - 333
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Chang, S.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration (FDA), 1401 Rockville Pike, HFM-222, Rockville, MD 20852, USA.
N1 - Accession Number: 20073101734. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Background: From July to September 1999, due to a concern of toxicity from exposure to thimerosal-containing vaccines, the American Academy of Pediatrics and U.S. Public Health Service temporarily recommended delaying the administration of first dose of hepatitis B vaccine until the age of 2-6 months for infants born to hepatitis B surface antigen negative mothers. Our objectives were to determine whether the recommendation affected the rate of perinatal hepatitis B infection in a multistate managed care population; to describe neonatal and early childhood cases of hepatitis B infection and to evaluate a possible role of the recommendation; and to assess the timeliness, with respect to the U.S. childhood immunization schedule, of vaccinations during the first 2 years of life. Methods: We identified 3 cohorts of infants born before (July 1998 to June 1999), during (July 1999 to September 1999) and after (October 1999 to September 2000) the recommendation period. We used automated claims data to identify possible neonatal and early childhood hepatitis B cases using specific ICD-9 diagnosis and CPT procedure codes and validated cases through medical record review. Using Health Plan Employer Data and Information Set (HEDIS) data, we calculated vaccination coverage for the first dose of hepatitis B vaccine at 3-month intervals from January 1999 to September 2000. Results: The eligible populations in the "before," "during" and "after" cohorts were 29 347, 7791 and 29 215 infants, respectively. Of 41 possible hepatitis B cases identified in the 3 cohorts, we confirmed 1 case in the after cohort with medical record review. Despite receiving the first dose of hepatitis B vaccine and hepatitis B immunoglobulin within 12-24 hours of birth, the infant was diagnosed with laboratory-confirmed chronic hepatitis B at age of 9 months. An analysis of HEDIS data showed that vaccination coverage for the first dose of hepatitis B vaccine was 98% (January to March 1999) and 96% (April to June 1999) for the "before" cohort and 66% for the "during" cohort. For the "after" cohort the coverage was 72% (October to December 1999), 83% (January to March 2000), 91% (April to June 2000) and 95% (July to September 2000). Conclusions: This study did not identify any perinatal hepatitis B transmission among health plan enrollees associated with the 1999 recommendation. The recommendation did result in a delay of hepatitis B birth dose in the "during" cohort as intended for infants born to hepatitis B surface antigen negative mothers. Six months after the recommendation was rescinded there was still a delay in the timing of first dose of hepatitis B vaccine, but the timing had returned to the prerecommendation level after 9-12 months.
KW - hepatitis B
KW - human diseases
KW - immunization
KW - neonates
KW - vaccination
KW - viral hepatitis
KW - USA
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - delay
KW - immune sensitization
KW - newborn infants
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073101734&site=ehost-live&scope=site
UR - http://www.pidj.com/
UR - email: robert.ball@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki syndrome in Denmark.
AU - Fischer, T. K.
AU - Holman, R. C.
AU - Yorita, K. L.
AU - Belay, E. D.
AU - Melbye, M.
AU - Koch, A.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2007///
VL - 26
IS - 5
SP - 411
EP - 415
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Fischer, T. K.: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases (DVRD), National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), US Department of Health and Human Services (DHHS), Atlanta, Georgia, USA.
N1 - Accession Number: 20073135905. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - Objective: To describe the epidemiologic characteristics of Kawasaki syndrome (KS) and to estimate national KS incidence rates among children in Denmark. Methods: A retrospective population-based study using hospital discharge records with a KS diagnosis for children younger than 15 years selected from the Danish National Hospital Register for 1981-2004. Incidence rates were calculated using the number of KS patients and corresponding census data. Results: During 1981-2004, 360 children younger than 15 years were hospitalized with KS in Denmark, with 73% younger than 5 years. In this age group, the average annual incidence of KS gradually increased from 1981 to 1999 and thereafter stabilized at 4.5 to 5.0 per 100 000 person-years. The incidence was greater for boys than for girls (RR=1.6, 95% CI=1.2-2.0) and was highest among infants younger than 1 year (4.5), declining with increasing age (P=0.03). However, the age-specific decline in incidence was only observed for boys, whereas the incidence for girls remained unchanged by age. The median length of hospital stay was 12 days, and the incidence peaked in the winter months. Conclusions: Major epidemiologic characteristics identified among Danish childhood KS are consistent with those described in previous studies, such as highest incidence among young children and winter-seasonality. The KS incidence rate among children younger than 5 years in Denmark increased steadily during the early study period (coinciding with global recognition of KS) and seems to have stabilized from 1998-1999 onwards. Although the incidence among Danish children was lower than that reported for several other European countries, differences in methodology challenge definite comparisons.
KW - boys
KW - children
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - girls
KW - human diseases
KW - infants
KW - Kawasaki disease
KW - morbidity
KW - preschool children
KW - Denmark
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Scandinavia
KW - Northern Europe
KW - Europe
KW - mucocutaneous lymph node syndrome
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073135905&site=ehost-live&scope=site
UR - http://www.pidj.com/
UR - email: ako@ssi.dk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - On modelling response propensity for dwelling unit (DU) level non-response adjustment in the Medical Expenditure Panel Survey (MEPS).
AU - Wun, L. M.
AU - Ezzati-Rice, T. M.
AU - Diaz-Tena, N.
AU - Greenblatt, J.
A2 - Pallos, L. L.
A2 - Andrew, M. E.
A2 - Banarjee, S. N.
A2 - Lee, T. D.
A2 - Pals, S. L.
A2 - Sieber, W. K.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 2007///
VL - 26
IS - 8
SP - 1875
EP - 1884
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0277-6715
AD - Wun, L. M.: Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Room 5240, Rockville, MD 20850, USA.
N1 - Accession Number: 20073058767. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - Non-response is a common problem in household sample surveys. The Medical Expenditure Panel Survey (MEPS), sponsored by the Agency for Healthcare Research and Quality (AHRQ), is a complex national probability sample survey. The survey is designed to produce annual national and regional estimates of health-care use, expenditures, sources of payment, and insurance coverage for the U.S. civilian non-institutionalized population. The MEPS sample is a sub-sample of respondents to the prior year's National Health Interview Survey (NHIS) conducted by the National Center for Health Statistics (NCHS). The MEPS, like most sample surveys, experiences unit, or total, non-response despite intensive efforts to maximize response rates. This paper summarizes research on comparing alternative approaches for modelling response propensity to compensate for dwelling unit (DU), i.e. household level non-response in the MEPS. Non-response in sample surveys is usually compensated for by some form of weighting adjustment to reduce the bias in survey estimates. To compensate for potential bias in survey estimates in the MEPS, two separate non-response adjustments are carried out. The first is an adjustment for DU level non-response at the round one interview to account for non-response among those households subsampled from NHIS for the MEPS. The second non-response adjustment is a person level adjustment to compensate for attrition across the five rounds of data collection. This paper deals only with the DU level non-response adjustment. Currently, the categorical search tree algorithm method, the chi-squared automatic interaction detector (CHAID), is used to model the response probability at the DU level and to create the non-response adjustment cells. In this study, we investigate an alternative approach, i.e. logistic regression to model the response probability. Main effects models and models with interaction terms are both evaluated. We further examine inclusion of the base weights as a covariate in the logistic models. We compare variability of weights of the two alternative response propensity approaches as well as direct use of propensity scores. The logistic regression approaches produce results similar to CHAID; however, using propensity scores from logistic models with interaction terms to form five classification groups for weight adjustment appears to perform best in terms of limiting variability and bias.
KW - costs
KW - dwellings
KW - expenditure
KW - health care
KW - health insurance
KW - mathematical models
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073058767&site=ehost-live&scope=site
UR - email: lwun@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consumer decisions on storage of packaged foods.
AU - Lando, A. M.
AU - Fein, S. B.
JO - Food Protection Trends
JF - Food Protection Trends
Y1 - 2007///
VL - 27
IS - 5
SP - 307
EP - 313
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 1541-9576
AD - Lando, A. M.: HFS 020, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083169056. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Agricultural Engineering
N2 - We investigate the causes of consumer uncertainty regarding storage of packaged foods by examining the characteristics of the consumers, the type of food products and packaging, and where the product was stored at purchase. Consumers' self-reported refrigeration practices from the 1998 Food Safety Survey are analysed descriptively and by logistic regression. Eleven percent of the 2,001 respondents reported difficulty during the past three months in deciding whether to refrigerate a packaged food. When consumers do have difficulty, it is likely that the products either are new to them or need to be stored in an unexpected way. Those most likely to report uncertainty about whether to refrigerate were people of middle age and people likely to be more attuned to food safety issues - those who have some college or higher education, who look at many sources of food information, and who thought that a household member had a recent foodborne illness. The results suggest that additional education may be needed to inform consumers about proper refrigeration and that storage information on packages is particularly important for foods that are stored at room temperature until opened but that then need refrigeration.
KW - characterization
KW - consumers
KW - education
KW - food
KW - food products
KW - food safety
KW - foodborne diseases
KW - foods
KW - households
KW - middle age
KW - packaging
KW - refrigeration
KW - storage
KW - Education, Extension, Information and Training (General) (CC000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Food Service (QQ700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083169056&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: Amy.lando@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide.
AU - Wiesenfeld, P. L.
AU - Garthoff, L. H.
AU - Sobotka, T. J.
AU - Suagee, J. K.
AU - Barton, C. N.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2007///
VL - 27
IS - 5
SP - 421
EP - 433
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0260-437X
AD - Wiesenfeld, P. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, Neurotoxicity and In Vitro Toxicology Branch, Laurel, Maryland, USA.
N1 - Accession Number: 20083244790. Publication Type: Journal Article. Language: English. Registry Number: 64-86-8. Subject Subsets: Plant Genetic Resources; Aromatic & Medicinal Plants
N2 - The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg-1 body weight) of colchicine (COL) was determined in young, mature male and female Sprague-Dawley rats. The effect of COL was evaluated in the presence or absence of additional treatment variables that included vehicle and lipopolysaccharide (LPS) pre-exposure. The vehicle for COL was either Half and Half cream (H & H) or saline, and each group included pretreatment with either saline or a low, minimally toxic dose (83 µg kg-1 body weight) of LPS. Colchicine toxicity in both male and female age-matched rats was characterized by progressively more severe dose-related clinical signs of toxicity. These included mortality, decreased body weight and feed intake during the first several days after dosing, with recovery thereafter in surviving animals. There were differences in the severity of the toxic response to COL between male and female rats. The most notable sex-related difference was in COL lethality. Female rats were two times more susceptible to the lethal effects of COL than male rats. Saline or H & H delivery vehicles did not result in any apparent qualitative or quantitative differences in COL toxicity. LPS pretreatment significantly potentiated COL lethality in both males and females, although the potentiation in males was greater than in females. LPS pretreatment modestly increased the COL induced anorexic effect in surviving males, but not in surviving female animals. LPS did not appear to modulate either the body weights or clinical signs of COL induced toxicity in surviving males or females.
KW - anorexia
KW - body weight
KW - colchicine
KW - feed intake
KW - lipopolysaccharides
KW - mortality
KW - secondary metabolites
KW - sex differences
KW - survival
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - inappetence
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083244790&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/114173575/abstract
UR - email: paddy.wiesenfeld@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Characteristics and difficulties in clinical trials of new traditional Chinese drugs.
AU - Wang HaiNan
T2 - Chinese Journal of Integrated Traditional and Western Medicine
JO - Chinese Journal of Integrated Traditional and Western Medicine
JF - Chinese Journal of Integrated Traditional and Western Medicine
Y1 - 2007///
VL - 27
IS - 7
SP - 650
EP - 652
CY - Beijing; China
PB - Editorial Board of Chinese Journal of Integrated Traditional and Western Medicine
SN - 1003-5370
AD - Wang HaiNan: Center for Drug Evaluation, State Food and Drug Administration, Beijing (100038), China.
N1 - Accession Number: 20073249877. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 9 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Therapeutic efficacy is the point of starting and ending for research and developing of new traditional Chinese drugs, and clinical trials could provide a good platform for its efficacy evaluation. The characteristics of Chinese patent medicine is clarified in this paper by comparing its difference from Chinese herbal decoction, and the characteristics and difficulties in clinical trials for developing Chinese new drugs were also probed in referrence to the present situation and progress of the concerning topics.
KW - characteristics
KW - clinical trials
KW - drug development
KW - herbal drugs
KW - pharmacology
KW - herbal medicines
KW - Non-food/Non-feed Plant Products (SS200)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073249877&site=ehost-live&scope=site
UR - http://www.cjim.cn
UR - email: md_wanghainan@yahoo.com.cn
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Barriers to and facilitators of implementing an intervention to reduce the incidence of catheter-associated bloodstream infections.
AU - Kidd, K. M.
AU - Sinkowitz-Cochran, R. L.
AU - Giblin, T. B.
AU - Tokars, J. I.
AU - Cardo, D. M.
AU - Solomon, S. L.
T2 - Infection Control and Hospital Epidemiology
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2007///
VL - 28
IS - 1
SP - 103
EP - 105
CY - Chicago; USA
PB - University of Chicago Press
SN - 0899-823X
AD - Kidd, K. M.: Centers for Disease Control and Prevention, United States Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20073180835. Publication Type: Correspondence. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - The perceived barriers to and facilitators of implementing a multicentre bloodstream infection (BSI) educational intervention to prevent nosocomial infections in intensive care units (ICUs) at 7 academic medical centres in the USA were investigated, with the purpose of providing a valuable guide for future patient safety interventions and evaluations. Qualitative data were collected retrospectively and key informant interviews were performed in November 2002. Nineteen respondents representing 7 institutions were interviewed. Seven of the 19 respondents were principal investigators (PIs), 7 were co-PIs, and 5 were other staff. In addition, 13 were physicians, 5 were nurses, and one was a research assistant. Six of the institutions implemented the intervention in 2 ICUs; the other implemented it in 3 ICUs. The self-study module and the pretest and posttest components were implemented by all the institutions and/or fact sheets were used by 6 institutions. "Buy-in" from nursing and medical leadership was mentioned by a majority of respondents in all institutions as necessary for getting the intervention introduced to, and accepted by, the institution. In addition, they reported the need to acquire assistance from other committees and to change or implement a policy to facilitate the intervention. On the other hand, logistics and scheduling were identified by the respondents from all institutions as barriers to the implementation of the intervention. The respondents from most institutions also mentioned low levels of involvement and lack of "buy-in" from clinicians as barriers to implementation. Majority of the respondents would recommend the intervention in its entirety to other hospitals, whereas some respondents would recommend only certain components of the intervention. It is suggested that understanding the perceived barriers to and facilitators of initiating and implementing an intervention, such as this one for the prevention of catheter-associated BSI, can provide a valuable insight into the success of recommended prevention strategies.
KW - catheters
KW - disease prevention
KW - education programmes
KW - health education
KW - health programs
KW - hospitals
KW - human diseases
KW - intensive care units
KW - nosocomial infections
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - educational programs
KW - hospital infections
KW - United States of America
KW - Education and Training (CC100)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073180835&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/ICHE/journal/issues/v28n1/2006056/2006056.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An overview of neurological disorders in Wales.
AU - Jader, L.
JO - Neuroepidemiology
JF - Neuroepidemiology
Y1 - 2007///
VL - 28
IS - 2
SP - 65
EP - 78
CY - Basel; Switzerland
PB - S Karger AG
SN - 0251-5350
AD - Jader, L.: The National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, Wales, UK.
N1 - Accession Number: 20073220827. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This pragmatic work was undertaken to assist commissioners of health services in Wales in their planning for future provision of services for neurological and neurosurgical patients. A literature search, which was carried out to ascertain the epidemiology of neurological and neurosurgical disorders in Wales, revealed limited epidemiological surveys of patients in Wales, while other literatures although outdated were still relevant. More recent national reports, published by professional bodies and patients' organizations, were also identified. These disorders were also grouped according to their aetiology and symptoms into 13 groups. Using all the available literature, total estimates of annual incidence and point prevalence of these disorders were arrived at. We can conclude that approximately 5.8% of the population in Wales are affected by neurological and neurosurgical disorders that include headaches, traumatic and infectious diseases of the nervous system.
KW - aetiology
KW - disease prevalence
KW - epidemiological surveys
KW - epidemiology
KW - headaches
KW - health services
KW - human diseases
KW - infectious diseases
KW - nervous system
KW - nervous system diseases
KW - planning
KW - reviews
KW - surveys
KW - symptoms
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - causal agents
KW - communicable diseases
KW - etiology
KW - neuropathy
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Services (UU350)
KW - Health Economics (EE118) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073220827&site=ehost-live&scope=site
UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=98549&Ausgabe=232799&ProduktNr=224263
UR - email: Layla.Jader@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells.
AU - Soldatova, L. N.
AU - Tsai, C. M.
AU - Dobrovolskaia, E.
AU - Markovic´-Housley, Z.
AU - Slater, J. E.
JO - Allergy and Asthma Proceedings
JF - Allergy and Asthma Proceedings
Y1 - 2007///
VL - 28
IS - 2
SP - 210
EP - 215
CY - Providence; USA
PB - OceanSide Publications, Inc.
SN - 1088-5412
AD - Soldatova, L. N.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20073249676. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 59-23-4, 37341-29-0, 3458-28-4. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology
N2 - Honeybee venom hyaluronidase (Api m 2) is a major glycoprotein allergen. Previous studies have indicated that recombinant Api m 2 expressed in insect cells has enzyme activity and IgE binding comparable with that of native Api m 2. In contrast, Api m 2 expressed in Escherichia coli does not. In this study, we characterized the carbohydrate side chains of Api m 2 expressed in insect cells, and compared our data with the established carbohydrate structure of native Api m 2. We assessed both the monosaccharide and the oligosaccharide content of recombinant Api m 2 using fluorophore-assisted carbohydrate electrophoresis and HPLC. To identify the amino acid residues at which glycosylation occurs, we digested recombinant Api m 2 with endoproteinase Glu-C and identified the fragments that contained carbohydrate by specific staining. Recombinant Api m 2 expressed in insect cells contains N-acetylglucosamine, mannose, and fucose, as well as trace amounts of glucose and galactose, and the oligosaccharide analysis is consistent with heterogeneous oligosaccharide chains consisting of two to seven monosaccharides. No sialic acid or N-acetylgalactosamine were detected. These results are similar to published data for native Api m 2, although some monosaccharide components appear to be absent in the recombinant protein. Analysis of proteolytic digests indicates that of the four candidate N-glycosylation sites, carbohydrate chains are attached at asparagines 115 and 263. Recombinant Api m 2 expressed in insect cells has enzymic activity and IgE binding comparable with the native protein, and its carbohydrate composition is very similar.
KW - allergens
KW - amino acids
KW - biochemistry
KW - carbohydrates
KW - characterization
KW - enzyme activity
KW - galactose
KW - glycoproteins
KW - honey bee venom
KW - honey bees
KW - HPLC
KW - IgE
KW - mannose
KW - oligosaccharides
KW - proteolysis
KW - recombinant proteins
KW - residues
KW - staining
KW - venoms
KW - Apis
KW - Escherichia coli
KW - Apis
KW - Apidae
KW - Hymenoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - E. coli
KW - glycosylation
KW - high performance liquid chromatography
KW - honeybee venom
KW - honeybees
KW - reagin
KW - reaginic antibodies
KW - saccharides
KW - venom
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Toxinology (VV820) (New March 2000)
KW - Apiculture (LL010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073249676&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/ocean/aap/2007/00000028/00000002/art00016
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hand hygiene practices after brief encounters with patients: an important opportunity for prevention.
AU - Dedrick, R. E.
AU - Sinkowitz-Cochran, R. L.
AU - Cunningham, C.
AU - Muder, R. R.
AU - Perreiah, P.
AU - Cardo, D. M.
AU - Jernigan, J. A.
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2007///
VL - 28
IS - 3
SP - 341
EP - 345
CY - Chicago; USA
PB - University of Chicago Press
SN - 0899-823X
AD - Dedrick, R. E.: Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20073175688. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - OBJECTIVE. To identify characteristics of encounters between healthcare workers (HCWs) and patients that correlated with hand hygiene adherence among HCWs. DESIGN. Observational study. SETTING. Intensive care unit in a Veterans Affairs hospital. PARTICIPANTS. HCWs. RESULTS. There were 767 patient encounters observed (48.6% involved nurses, 20.6% involved physicians, and 30.8% involved other HCWs); 39.8% of encounters involved patients placed under contact precautions. HCW contact with either the patient or surfaces in the patient's environment occurred during all encounters; direct patient contact occurred during 439 encounters (57.4%), and contact with environmental surfaces occurred during 710 encounters (92.6%). The median duration of encounters was 2 minutes (range, <1 to 51 minutes); 33.6% of encounters lasted 1 minute or less, with no significant occupation-associated differences in the median duration of encounters. Adherence with hand hygiene practices was correlated with the duration of the encounter, with overall adherences of 30.0% after encounters of ≤1 minute, 43.4% after encounters of >1 to ≤2 minutes, 51.1% after encounters of >3 to ≤5 minutes, and 64.9% after encounters of >5 minutes (P<.001 by the χ2 for trend). In multivariate analyses, longer encounter duration, contact precautions status, patient contact, and nursing occupation were independently associated with adherence to hand hygiene recommendations. CONCLUSIONS. In this study, adherence to hand hygiene practices was lowest after brief patient encounters (ie, <2 minutes). Brief encounters accounted for a substantial proportion of all observed encounters, and opportunities for hand contamination occurred during all brief encounters. Therefore, improving adherence after brief encounters may have an important overall impact on the transmission of healthcare-associated pathogens and may deserve special emphasis in the design of programs to promote adherence to hand hygiene practices.
KW - contacts
KW - disease prevention
KW - duration
KW - hands
KW - health care workers
KW - hygiene
KW - infection control
KW - nurses
KW - patients
KW - physicians
KW - Pennsylvania
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - doctors
KW - United States of America
KW - Environmental Pest Management (HH200)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073175688&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/ICHE/journal/issues/v28n3/2005362/brief/2005362.abstract.html
UR - email: jjernigan@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Beryllium: a modern industrial hazard.
AU - Kreiss, K.
AU - Day, G. A.
AU - Schuler, C. R.
JO - Annual Review of Public Health
JF - Annual Review of Public Health
Y1 - 2007///
VL - 28
SP - 259
EP - 277
CY - Palo Alto; USA
PB - Annual Reviews
SN - 0163-7525
AD - Kreiss, K.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073127948. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Registry Number: 7440-41-7. Subject Subsets: Public Health; Agricultural Biotechnology
N2 - Beryllium exposure can cause a granulomatous lung disease in workers who develop a lymphocyte-mediated sensitization to the metal. Workers in diverse industries are at risk because beryllium's properties are critical to nuclear, aerospace, telecommunications, electronic, metal alloy, biomedical, and semiconductor industries. The occupational air concentration standard's failure to protect beryllium workers is driving many scientific and occupational health advances. These developments include study of bioavailability of different physicochemical forms of beryllium, medical surveillance to show effectiveness of skin protection in preventing sensitization in high-risk processes, gene-environment interaction, transgenic mice for use in experimental research, and risk-based management of industrial exposures in the absence of effective exposure-response information. Beryllium sensitization and disease prevention are paradigms for much broader public health action in both occupational and general population settings.
KW - berylliosis
KW - beryllium
KW - exposure
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073127948&site=ehost-live&scope=site
UR - http://publhealth.AnnualReviews.org/
UR - email: kkreiss@cdc.gov\gday@cdc.gov\cschuler@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Needle-stick injuries in primary care in Wales.
AU - Atenstaedt, R. L.
AU - Payne, S.
AU - Roberts, R. J.
AU - Russell, I. T.
AU - Russell, D.
AU - Edwards, R. T.
JO - Journal of Public Health
JF - Journal of Public Health
Y1 - 2007///
VL - 29
IS - 4
SP - 434
EP - 440
CY - Oxford; UK
PB - Oxford University Press
SN - 1741-3842
AD - Atenstaedt, R. L.: National Public Health Service for Wales, Wales, UK.
N1 - Accession Number: 20083056543. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Accidental needle-stick injuries (NSIs) are a hazard for health-care workers and for the general public. Objectives: To estimate the presentation rate of NSIs to general medical practices, their relation to practice characteristics, and review practice policies for managing NSIs. Method: Descriptive study using logistic regression analysis. Results: Annual rates of 2.73 (95% CI 2.08, 3.50) occupational NSIs per 100 clinical practice staff and 2.14 (95% CI 1.39, 3.13) non-occupational NSIs per 100 000 practice population were recorded. Stepwise logistic regressions showed that chance of a practice reporting at least one occupational NSI in previous five years was best predicted by being a single-handed practice (decreased odds). In contrast, the chance of a practice reporting at least one non-occupational NSI was best predicted by being a rural practice (increased odds). About one in five practices possessed no written policy on managing NSIs. Stepwise logistic regressions showed that the chance of a practice owning a NSI policy was best predicted by being located in an LHB area with a coastline (increased odds). Conclusion: NSIs are an important public health issue in Wales. We have tried to address the lack of guidance by developing new guidelines in Wales.
KW - health care workers
KW - human diseases
KW - infectious diseases
KW - needlestick injuries
KW - occupational hazards
KW - occupational health
KW - primary health care
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - communicable diseases
KW - United Kingdom
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083056543&site=ehost-live&scope=site
UR - http://jpubhealth.oxfordjournals.org/cgi/content/abstract/29/4/434
UR - email: robert.atenstaedt@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Early responses associated with chronic pathology in murine schistosomiasis.
AU - Cêtre-Sossah, C. B.
AU - Montesano, M. A.
AU - Freeman, G. L., Jr.
AU - Willard, M. T.
AU - Colley, D. G.
AU - Secor, W. E.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2007///
VL - 29
IS - 5
SP - 241
EP - 249
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0141-9838
AD - Cêtre-Sossah, C. B.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20073096086. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 207137-56-2, 10102-43-9, 308079-78-9. Subject Subsets: Helminthology
N2 - Inbred male CBA/J mice infected with Schistosoma mansoni develop either hypersplenomegaly syndrome (HSS) or moderate splenomegaly syndrome (MSS) by 20 weeks of infection. Pathologically and immunologically, MSS and HSS closely parallel the intestinal and hepatosplenic clinical forms of schistosomiasis in humans, respectively. By 6 weeks after infection, mice that eventually will become MSS develop T cell-stimulatory, cross-reactive idiotypes (CRI) while HSS mice never produce CRI. Because presence of CRI is useful to predict degree of chronic pathology, we used this measure to investigate what other early immunological events occurred in animals destined to develop severe morbidity. At 8 weeks of infection, there was a strong inverse correlation between CRI and splenomegaly, egg counts, and liver hydroxyproline. Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4+ T cells was inversely correlated with serum CRI and directly correlated with spleen size. In contrast, spleen cell intracellular TNF-α and peritoneal cell production of nitric oxide demonstrated positive correlations with CRI and inverse correlations with measures of morbidity. Surprisingly, IL-10 and IFN-γ were not correlated with CRI levels. These studies link chronic pathology to certain immunological responses during the acute phase of schistosomiasis.
KW - animal models
KW - CD4+ lymphocytes
KW - clinical aspects
KW - colony stimulating factor
KW - disease course
KW - experimental infections
KW - immune response
KW - immunopathology
KW - interleukin 4
KW - interleukin 5
KW - laboratory animals
KW - nitric oxide
KW - schistosomiasis
KW - spleen
KW - splenomegaly
KW - tumour necrosis factor
KW - mice
KW - Schistosoma mansoni
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Schistosoma
KW - Schistosomatidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - bilharzia
KW - bilharziasis
KW - cachectin
KW - cachexin
KW - CD4+ cells
KW - clinical picture
KW - disease progression
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - schistosomosis
KW - Strigeida
KW - T4 lymphocytes
KW - tumor necrosis factor
KW - tumour necrosis factor-alpha
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073096086&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/pim
UR - email: was4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Optimising piperacillin/tazobactam dosing in paediatrics.
AU - Tornøe, C. W.
AU - Tworzyanski, J. J.
AU - Imoisili, M. A.
AU - Alexander, J. J.
AU - Korth-Bradley, J. M.
AU - Gobburu, J. V.
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2007///
VL - 30
IS - 4
SP - 320
EP - 324
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0924-8579
AD - Tornøe, C. W.: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20073246975. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 61477-96-1, 89786-04-9. Subject Subsets: Public Health
N2 - Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this analysis is to describe the basis for the dosing recommendations in this age group. Pharmacokinetic (PK) parameters and demographic covariates from 53 children enrolled in two paediatric studies were used in the analysis. Individual drug clearance (CL) values calculated by non-compartmental methods were available. The influence of demographic covariates on CL was investigated by non-linear regression. The analysis identified CL to be dependent on body weight. CL was also found to be influenced by age in paediatric patients ≤2 years, which is consistent with the expectation based on maturation of renal function. The population PK analysis and simulations, utilising comparable adult exposures as a basis to explore optimal dosing, resulted in the following dosing recommendations: for paediatric patients ≥9 months, a dose of 100/12.5 mg/kg every 8 h showed exposures similar to adults; for paediatric patients aged 2-9 months, the dose of 100/12.5 mg/kg should be reduced by a factor of 0.8 (i.e. 80/10 mg/kg), likely due to immature renal function. Based upon this analysis, dosing recommendations for paediatric patients down to 2 months of age were incorporated in the labelling. No data were available to allow additional recommendations for paediatric patients <2 months of age to be made.
KW - antibacterial agents
KW - body weight
KW - children
KW - dosage
KW - drug therapy
KW - multiple drug therapy
KW - optimization
KW - pharmacokinetics
KW - piperacillin
KW - renal function
KW - tazobactam
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - combination drug therapy
KW - kidney function
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073246975&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09248579
UR - email: christoffer.tornoe@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance of prescription drug-related mortality using death certificate data.
AU - Wysowski, D. K.
JO - Drug Safety
JF - Drug Safety
Y1 - 2007///
VL - 30
IS - 6
SP - 533
EP - 540
CY - Auckland; New Zealand
PB - Adis International Ltd
SN - 0114-5916
AD - Wysowski, D. K.: Division of Drug Risk Evaluation, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20073220753. Publication Type: Journal Article. Language: English. Registry Number: 561-27-3, 1095-90-5, 76-99-3, 8008-60-4, 50-67-9. Subject Subsets: Public Health
N2 - Background: The prescription drugs or drug classes that are most frequently associated with death in the US might be identifiable from death certificate data. Objective: To identify the drugs/drug classes associated with the greatest numbers of deaths in the US that might be considered as possible targets for prevention. Study design: US vital statistics data were accessed in order to identify International Classification of Diseases (10th Revision) [ICD-10] codes indicating that prescription drugs had caused or contributed to death and diseases with significant drug-related mortality. Main outcome measure: ICD-10 codes for primarily prescription drugs that were listed as the underlying cause or as 'total mentions' on death certificates and were implicated in ≥1000 deaths in any one year were selected. The annual number of deaths by ICD-10 code was obtained from the Division of Vital Statistics, National centre for Health Statistics. Codes for diseases with significant drug-related aetiologies and involvement in ≥1000 deaths in any one year were also identified and analysed separately. Results: For the selected ICD-10 codes, a total of 25 031 deaths were listed as having a prescription drug as the underlying cause in 2003, compared with 16 135 in 1999, a 55% increase. Total mentions of these codes increased from 46 523 in 1999 to 72 080 in 2003, also a 55% increase. Most codes involved 'poisonings' (overdose or the wrong substance given or taken in error that is accidental, intentional or with undetermined intent). Drugs associated with poisoning deaths had central nervous system effects. Among the codes associated with specified drug classes, poisonings and accidental poisonings involving narcotics, hallucinogens, psychoactive substances and opioids (other than opium and heroin) were associated with the largest numbers of deaths. Drug-related codes associated with the largest percentage increases in deaths between 1999 and 2003 included poisoning due to methadone (275%); poisoning by other and unspecified antidepressants (primarily selective serotonin reuptake inhibitors) [130%]; and poisoning by psychostimulants with potential for abuse (amfetamines and drugs for attention deficit hyperactivity disorder) [117%]. Anticoagulants were associated with the largest numbers of deaths with codes involving "adverse effects in therapeutic use". Among diseases with significant drug-related aetiologies, Clostridium difficile enterocolitis (associated primarily with antibacterials) had the largest percentage increase in total mentions, with a 203% rise between 1999 and 2003. Conclusions: Deaths due to overdoses are the most prominent cause of drug-related mortality in death certificate data. Certain drugs and drug classes, especially the opioids (e.g. narcotics, methadone), psychoactive drugs (e.g. antidepressants, amfetamines), anticoagulants and antibacterials (which cause or contribute to C. difficile enterocolitis) are associated with large and increasing numbers of deaths and preventive strategies should be considered.
KW - abnormal behaviour
KW - anticoagulants
KW - behaviour
KW - central nervous system
KW - enterocolitis
KW - health
KW - heroin
KW - human behaviour
KW - human diseases
KW - hyperactivity
KW - methadone
KW - mortality
KW - nervous system
KW - neurotropic drugs
KW - opium
KW - overdose
KW - poisoning
KW - prescriptions
KW - serotonin
KW - statistics
KW - Clostridium
KW - Clostridium difficile
KW - man
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 5-HT
KW - 5-hydroxytryptamine
KW - abnormal behavior
KW - bacterium
KW - behavior
KW - CNS
KW - death rate
KW - deviant behaviour
KW - diacetylmorphine
KW - diamorphine
KW - human behavior
KW - neuroactive drugs
KW - toxicosis
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073220753&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/adis/dsf/2007/00000030/00000006/art00007
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Facilitating effective health promotion practice in a public health unit: lessons from the field.
AU - Berentson-Shaw, J.
AU - Price, K.
JO - Australian and New Zealand Journal of Public Health
JF - Australian and New Zealand Journal of Public Health
Y1 - 2007///
VL - 31
IS - 1
SP - 81
EP - 86
CY - Curtin; Australia
PB - Public Health Association of Australia Inc
SN - 1326-0200
AD - Berentson-Shaw, J.: Auckland Regional Public Health Service, 11 Dorking Road, Brooklyn, Wellington, New Zealand.
N1 - Accession Number: 20073197357. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Objectives: Health promotion is a core function of public health services and improving the effectiveness of health promotion services is an essential part of public health service development. This report describes the rationale, the process and the outcomes of a realignment designed to improve the effectiveness of health promotion activities in a public health unit (PHU) in New Zealand. Methods: A practice environment analysis revealed several factors that were hindering the effectiveness of the health promotion unit's (HPU) activities. Two primary change mechanisms were implemented. The first was an outcomes-focused model of planning and service delivery (to support evidenced-based practice), the second was the reorganisation of the HPU from a topicsbased structure to an integrated one based on a multi-risk factor paradigm of population health. Results: During the realignment barriers were encountered on multiple levels. At the individual level, unfavourable attitudes to changes occurred because of a lack of information and knowledge about the benefits of evidence and research. At higher levels, barriers included resourcing concerns, a lack of organisational commitment and understanding, and tensions between the political need for expedient change and research and development need for timely consideration of the impact of different models of practice. Conclusions and Implications: This realignment took place within the context of a changing public health environment, which is significantly altering the delivery of public health and health promotion. Realignments designed to facilitate more effective health promotion and public health practice will continue, but need to do so in the light of others' experience and debate.
KW - health
KW - health education
KW - health promotion
KW - knowledge
KW - public health
KW - New Zealand
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Education and Training (CC100)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073197357&site=ehost-live&scope=site
UR - http://www.phaa.net.au/documents/17-07-07_ANZJPH_2007-1.pdf
UR - email: jessicaberentson@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The influence of velocity of stretch-shortening contractions on muscle performance during chronic exposure: age effects.
AU - Cutlip, R. G.
AU - Baker, B. A.
AU - Geronilla, K. B.
AU - Kashon, M. L.
AU - Wu, J. Z.
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
Y1 - 2007///
VL - 32
IS - 3
SP - 443
EP - 453
CY - Ottawa; Canada
PB - National Research Council of Canada
SN - 1715-5312
AD - Cutlip, R. G.: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 25606, USA.
N1 - Accession Number: 20073197684. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Aging increases injury susceptibility and impairs the ability to adapt to repetitive exposures of mechanical loading. The objective of this research was to investigate if movement velocity affects response to a chronic administration of stretch-shortening cycles (SSCs) differently in young vs. old rats. Dorsiflexor muscles of old (30 months, n=5) and young rats (12 weeks, n=6) were exposed 3 times/week for 4.5 weeks to a protocol of 80 maximal SSCs per exposure in vivo. Skeletal muscle response was characterized by high- (500°/s) and low- (60°/s) velocity dynamic performance, which was evaluated using peak eccentric force, isometric pre-stretch force, eccentric force enhancement above the isometric pre-stretch force, negative work, and positive work. The performance of the young and old groups was not statistically different at the start of the exposure. By the end of the exposure, however, a statistical difference was noted-performance increased significantly in the young animals and decreased significantly in the old animals. The SSC velocity had a profound effect on muscle response. The young animals' high- and low-velocity performances increased during the chronic exposure period, whereas the old animals' performances declined. High-velocity performance increased more than low-velocity performance in young animals. In contrast, old animals suffered the most loss in high-velocity performance over the chronic exposure period. A chronic exposure of SSCs results in a significant performance increase in young animals, and a significant performance decrease in old animals. These differences are more profound during high-velocity movements. These findings suggest that age may impair the ability of skeletal muscle to adapt to repetitive mechanical loading, particularly during high-velocity movements.
KW - age
KW - age differences
KW - animal models
KW - laboratory animals
KW - muscle contraction
KW - muscle physiology
KW - skeletal muscle
KW - velocity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073197684&site=ehost-live&scope=site
UR - http://apnm.nrc.ca
UR - email: rgc8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis control among people in U.S. Immigration and Customs Enforcement custody.
AU - Schneider, D. L.
AU - Lobato, M. N.
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2007///
VL - 33
IS - 1
SP - 9
EP - 14
CY - New York; USA
PB - Elsevier
SN - 0749-3797
AD - Schneider, D. L.: Division of Immigration Health Services, U.S. Public Health Service, 1220 L Street, NW, Suite 500, Washington, DC 20005, USA.
N1 - Accession Number: 20083105744. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Rural Development; Tropical Diseases
N2 - Background: People detained by United States Immigration and Customs Enforcement (ICE) are a high-risk population for tuberculosis (TB). Detainees are screened for TB upon intake, and TB patients are reported to the Division of Immigration Health Services (DIHS). Methods: TB case reports were reviewed for ICE detainees reported to DIHS during 2004-2005. Case counts and frequency distributions are presented. Case counts are stratified by demographic characteristics, release status, laboratory and clinical findings, HIV/AIDS status, and drug resistance. Case rates were calculated for patients housed at facilities with DIHS staffing. Duration of treatment and of ICE custody is provided. Analyses were conducted in 2006. Results: During 2004 and 2005, 76 and 142 TB patients were reported, respectively. The TB case rate was 82.6/100 000 in 2004 and 121.5/100 000 in 2005. The culture-confirmed case rate of 55.8/100 000 in 2005 was 2.5 times higher than the case rate in the U.S. foreign-born population. Of 218 patients, 127 (58.3%) had Mycobacterium tuberculosis-positive sputum cultures, 70 (32.1%) had acid-fast bacilli-positive sputum smears, and 36 (16.5%) were symptomatic at diagnosis. Patients from Mexico, Honduras, Guatemala, and El Salvador accounted for 184 cases (84.4%) and 184 patients (84.4%) were repatriated. TB patients spent an average 82.6 days in treatment before release or repatriation. Conclusions: Screening at intake to ICE custody has helped DIHS staff in diagnosing TB and starting patients on treatment, but patients are usually deported before completing therapy. Because of deportation, and sometimes re-entry into the United States, unique collaborations are required to support completion of treatment.
KW - acquired immune deficiency syndrome
KW - case reports
KW - demography
KW - drug resistance
KW - health services
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - screening
KW - smears
KW - sputum
KW - tuberculosis
KW - El Salvador
KW - Guatemala
KW - Honduras
KW - Mexico
KW - USA
KW - man
KW - Mycobacterium
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - CACM
KW - Central America
KW - America
KW - Developing Countries
KW - Latin America
KW - APEC countries
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - Developed Countries
KW - acid fastness
KW - AIDS
KW - bacterium
KW - human immunodeficiency virus infections
KW - Salvador
KW - screening tests
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Demography (UU200)
KW - Pesticide and Drug Resistance (HH410)
KW - Health Services (UU350)
KW - Health Economics (EE118) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083105744&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VHT-4P00WVW-2-1&_cdi=6075&_user=6686535&_orig=browse&_coverDate=07%2F31%2F2007&_sk=999669998&view=c&wchp=dGLzVzz-zSkWW&md5=094bf191a5c939c95a18ad4ec68cf7fd&ie=/sdarticle.pdf
UR - email: Diana.Schneider@dhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational and non-occupational injuries in the United States Army: focus on gender.
AU - Tiesman, H. M.
AU - Peek-Asa, C. L.
AU - Zwerling, C. S.
AU - Sprince, N. L.
AU - Amoroso, P. J.
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2007///
VL - 33
IS - 6
SP - 464
EP - 470
CY - New York; USA
PB - Elsevier
SN - 0749-3797
AD - Tiesman, H. M.: National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road M/S 1811, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083105806. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - Background: The differences in occupational and non-occupational injuries between military men and women have not been documented. This study compares occupational and non-occupational injuries between male and female United States Army soldiers by examining injury hospitalization rates and characteristics. Methods: The U.S. Army's Total Army Injury and Health Outcomes Database was searched for hospitalizations with ICD-9-CM codes for injury (800-959.9) between 1992 and 2002. Injury rates were calculated using yearly U.S. Army population data and compared using rate ratios. Injury characteristics were compared among categories of the Trauma Code (on duty; off duty; scheduled training, schemes, and exercises), stratified by gender. Results: Included in this analysis were 792 women for an injury hospitalization rate of 11.0 per 1000 individuals (95% confidence interval [CI]=8.5-13.5) and 4879 men for a rate of 15.5 per 1000 individuals (95% CI=14.0-16.9). While women had significantly more injuries during scheduled training, schemes, and exercises than men (p=0.0001), there were few differences in the cause of those injuries. Women had longer average hospital stays compared to men due to these injuries (9.3 days vs 7.4 days, p=0.002), although these injuries were not more severe (average Injury Severity Score=3.5 for men vs average ISS for women=3.5, p=0.79). There was no difference between the genders in the percent of injuries that occurred off duty; however, men were more likely to get injured due to sports and athletics (p=0.001) and due to fighting (p=0.017) while off duty compared to women. Conclusions: Injury prevention messages for military personnel should focus on reducing risk factors for both on- and off-duty injuries.
KW - armed forces
KW - men
KW - military personnel
KW - personnel
KW - risk factors
KW - soldiers
KW - trauma
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - staff
KW - traumas
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083105806&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VHT-4R5PGMB-6-1&_cdi=6075&_user=6686535&_orig=browse&_coverDate=12%2F31%2F2007&_sk=999669993&view=c&wchp=dGLbVzb-zSkzk&md5=59021d81c9957baeafb7ee59d12e76c7&ie=/sdarticle.pdf
UR - email: htiesman@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pediatrician perspectives on children's access to mental health services: consequences and potential solutions.
AU - Pfefferle, S. G.
JO - Administration and Policy in Mental Health and Mental Health Services Research
JF - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2007///
VL - 34
IS - 5
SP - 425
EP - 434
CY - Dordrecht; Netherlands
PB - Springer SBM
SN - 0894-587X
AD - Pfefferle, S. G.: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, 1 Brookings Dr., Campus Box 1093, St. Louis, MO 63130, USA.
N1 - Accession Number: 20083084362. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Public Health
N2 - This paper examines pediatricians' perspectives regarding access to children's mental health care. In response to a question about factors that help or hinder coordination of care 190 respondents voluminously wrote about mental health access barriers. Responses were qualitatively analyzed to understand pediatricians' perspectives. Four thematic areas emerged: Insurance issues; availability of mental health specialty providers; state mental health systems; and pediatricians' attempts to improve access to mental health services. Pediatricians' responses included educating themselves, using telemedicine, and hiring co-located mental health specialists. Recommendations are made to address pediatricians' treatment of children with mental illnesses and their access to treatment resources.
KW - attitudes
KW - child care
KW - children
KW - health services
KW - mental health
KW - pediatricians
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083084362&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/450645263x6w21v5/?p=54cd700f44b143e1bad198b7737641e8&pi=0
UR - email: spfefferle@gwbmail.wustl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment, authorization and access to medicaid managed mental health care.
AU - Masland, M. C.
AU - Snowden, L. R.
AU - Wallace, N. T.
JO - Administration and Policy in Mental Health and Mental Health Services Research
JF - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2007///
VL - 34
IS - 6
SP - 548
EP - 562
CY - Dordrecht; Netherlands
PB - Springer SBM
SN - 0894-587X
AD - Masland, M. C.: Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, 2140 Shattuck Ave, #409, Berkeley, CA 94720-1414, USA.
N1 - Accession Number: 20083084378. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Examined were effects on access of managed care assessment and authorization processes in California's 57 county mental health plans. Primary data on managed care implementation were collected from surveys of county plan administrators; secondary data were from Medicaid claims and enrollment files. Using multivariate fixed effects regression, we found that following implementation of managed care, greater access occurred in county plans where assessments and treatment were performed by the same clinician, and where service authorizations were made more rapidly. Lower access occurred in county plans where treating clinicians authorized services themselves. Results confirm the significant effects of managed care processes on outcomes and highlight the importance of system capacity.
KW - health care
KW - health insurance
KW - mental health
KW - physicians
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - doctors
KW - United States of America
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083084378&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/a5616g851l01v303/?p=a4c9601204ec4771b4341d71a1e3aa25&pi=6
UR - email: mmasland@berkeley.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternal self-efficacy and 1-5-year-old children's brushing habits.
AU - Finlayson, T. L.
AU - Siefert, K.
AU - Ismail, A. I.
AU - Sohn, W. S.
JO - Community Dentistry and Oral Epidemiology
JF - Community Dentistry and Oral Epidemiology
Y1 - 2007///
VL - 35
IS - 4
SP - 272
EP - 281
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0301-5661
AD - Finlayson, T. L.: Agency for Healthcare Research and Quality (AHRQ), University of California, Berkeley, California, USA.
N1 - Accession Number: 20073210904. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Objectives: This study investigates the relationships between maternal cognitive, behavioural and psychosocial factors and brushing practices in low-income African-American preschool children. Methods: Data came from a population-based sample of 1021 African-American families with at least one child <6 years of age and living in the 39 low-income Census tracts in Detroit, Michigan, USA. Analyses were limited to children aged 1-5 years and their mothers (n=719). Mothers were surveyed about oral health-related self-efficacy (OHSE), knowledge about appropriate bottle use (KBU), knowledge about children's oral hygiene (KCOH), oral health fatalism (OHF), their own toothbrushing behaviour, depressive symptoms (CES-D), parenting stress, practical social support, and their child's dental history. Children's 1-week reported brushing frequency was the main outcome measure. Analyses were conducted in SUDAAN to account for the complex sampling design. Results: Children's 1-week brushing frequency (range, 0-40) averaged 8.50 times per week among children aged 1-3 years and 9.75 among children aged 4-5 years. Maternal OHSE was a strong and significant predictor of children's brushing frequency; for each unit increase in OHSE, children aged 1-3 years were expected to brush 18% more frequently on average during 1 week (incidence density ratios (IDR)=1.18, 95% confidence interval (CI) 1.08-1.28; P<0.001), and children aged 4-5 years were expected to brush 9% more often (IDR=1.09, 95% CI 1.00-1.19; P<0.10). Mothers' KCOH score was also significantly positively associated with brushing frequency; for each unit increase on the KCOH scale, children aged 1-3 years were expected to brush 22% more frequently (IDR=1.22, 95% CI 1.10-1.35; P<0.001) and children aged 4-5 years were expected to brush 13% more frequently (IDR=1.13, 95% CI 1.02-1.26; P<0.05). If a mother brushed her own teeth at bedtime during the week, her younger child's brushing frequency was expected to increase by one-third (IDR=1.34, 95% CI 1.12-1.60; P<0.01) and among the children aged 4-5 years, brushing frequency was expected to increase by one-quarter (IDR=1.26, 95% CI 1.12-1.42; P<0.001). Availability of help with transportation and financial support were also relevant variables for children aged 1-3 years. Higher family income and dental insurance coverage were both positively associated with brushing among children aged 4-5 years. Conclusions: Several maternal cognitive, behavioural and psychosocial factors were associated with young children's brushing practices. Oral health-specific self-efficacy and knowledge measures are potentially modifiable cognitions; such findings suggest that intervening on these factors could help foster healthy dental habits and increase children's brushing frequency early in life.
KW - behaviour
KW - blacks
KW - children
KW - dental health
KW - hygiene
KW - low income groups
KW - maternal behaviour
KW - preschool children
KW - teeth
KW - Michigan
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Lake States of USA
KW - behavior
KW - maternal behavior
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073210904&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/com
UR - email: tracyf@berkeley.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007.
AU - Edwards, J. R.
AU - Peterson, K. D.
AU - Andrus, M. L.
AU - Tolson, J. S.
AU - Goulding, J. S.
AU - Dudeck, M. A.
AU - Mincey, R. B.
AU - Pollock, D. A.
AU - Horan, T. C.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2007///
VL - 35
IS - 5
SP - 290
EP - 301
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Edwards, J. R.: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Mailstop A-24, Atlanta GA 30333, USA.
N1 - Accession Number: 20083035227. Publication Type: Journal Article. Corporate Author: USA, NHSN Facilities Language: English. Subject Subsets: Public Health
KW - health care
KW - health services
KW - public health
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083035227&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4P050NW-5&_user=10&_coverDate=06%2F30%2F2007&_rdoc=5&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236686%232007%23999649994%23661011%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=267&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4b589f66c92786ff1ba5436bc73cb81c
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Psychosocial factors and early childhood caries among low-income African-American children in Detroit.
AU - Finlayson, T. L.
AU - Siefert, K.
AU - Ismail, A. I.
AU - Sohn, W. S.
JO - Community Dentistry and Oral Epidemiology
JF - Community Dentistry and Oral Epidemiology
Y1 - 2007///
VL - 35
IS - 6
SP - 439
EP - 448
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0301-5661
AD - Finlayson, T. L.: Agency for Healthcare Research and Quality (AHRQ), Scholar, School of Public Health, University of California, Berkeley, California, USA.
N1 - Accession Number: 20083003323. Publication Type: Journal Article. Language: English. Number of References: 75 ref. Subject Subsets: Public Health
N2 - Objectives: This study sought to advance knowledge of the social determinants of oral health, by examining how several specific maternal health beliefs, behaviors, and psychosocial factors relate to young children's early childhood caries (ECC) status in a lower-income African-American population. Methods: Data were collected by the Detroit Dental Health Project (NIDCR grant), a population-based study of 1021 African-American families with at least one child under 6 years of age and living in 39 low-income Census tracts in Detroit, Michigan. Analyses were limited to 719 children aged 1-5 years and their biological mothers, and conducted in SUDAAN to account for the complex sampling design. Survey data included health belief scales on mothers' self-efficacy, feelings of fatalism, knowledge about appropriate bottle use and children's oral hygiene needs, brushing habits, psychosocial measures of depressive symptoms (CES-D), parenting stress, and availability of instrumental social support. The child's age, dental insurance status, dental visit history, and 1-week brushing frequency were also included in the model. Children's ECC status, based on a dental examination, was the main outcome. The dental team used the International Caries Detection and Assessment System (ICDAS) criteria for caries detection. Each child was classified as either caries-free or having ECC or severe ECC (S-ECC) based on the case definition of ECC proposed by an expert panel for research purposes with preschool-aged children. Results: The dental team followed a specific examination protocol and established reliable and consistent ratings of ECC based on the ICDAS criteria. The inter-rater reliability kappa was 0.83 overall, and the intra-rater reliability kappa was 0.74 overall. One-third of the children had ECC, and 20% had severe ECC. Age of the child and lower parenting stress scores were each positively associated with ECC, while higher education and income were protective. Maternal oral health fatalism and knowledge of children's hygiene needs were associated with ECC among preschool-aged children. ECC was higher among younger children who had past restorative care. Conclusions: These findings call attention to the high prevalence of ECC in this population and the need to consider psychosocial as well as traditional risk factors in developing interventions to reduce oral health disparities.
KW - African Americans
KW - age
KW - children
KW - dental caries
KW - dental health
KW - education
KW - ethnic groups
KW - health beliefs
KW - human diseases
KW - income
KW - low income groups
KW - preschool children
KW - psychosocial aspects
KW - socioeconomic status
KW - stress
KW - teeth
KW - tooth diseases
KW - Michigan
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - East North Central States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Lake States of USA
KW - caries
KW - teeth caries
KW - tooth decay
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083003323&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/com
UR - email: tracyf@berkeley.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Spreading the word, not the infection: reaching hospitalists about the prevention of antimicrobial resistance.
AU - Bush-Knapp, M. E.
AU - Brinsley-Rainisch, K. J.
AU - Lawton-Ciccarone, R. M.
AU - Sinkowitz-Cochran, R. L.
AU - Dressler, D. D.
AU - Budnitz, T.
AU - Williams, M. V.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2007///
VL - 35
IS - 10
SP - 656
EP - 661
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Bush-Knapp, M. E.: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Road MS A-31, Atlanta, GA 30333, USA.
N1 - Accession Number: 20083011424. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: To reach and engage hospitalists in the prevention of antimicrobial resistance, the Society of Hospital Medicine and the Centers for Disease Control and Prevention developed and conducted a quality improvement workshop based on the Centers for Disease Control and Prevention's Campaign to Prevent Antimicrobial Resistance in Healthcare Settings. Methods: We aimed to examine motivating factors, perceived barriers, and cues to action for hospitalists to learn about and engage in the prevention of antimicrobial resistance and to determine whether a workshop can facilitate the implementation of a quality improvement project. Using the Health Belief Model as a theoretical framework, we interviewed hospitalists who attended (attendees) and did not attend (nonattendees) the workshop. Data were qualitatively coded and analyzed. Results: Nine attendees and 10 nonattendees participated in interviews. Motivating factors for attending the workshop included an interest in the topic of quality improvement and antimicrobial resistance prevention, the promotion of the workshop by institutions and colleagues, the opportunity to network with colleagues, and the qualifications of the presenter. Barriers to involvement in quality improvement efforts and the prevention of antimicrobial resistance for both attendees and nonattendees included perceived lack of time, other institutional priorities, and lack of administrative and institutional support. Attendees and nonattendees also identified perceived effective and preferred methods for receiving information about antimicrobial resistance, such as workshops and presentations, e-mail, institutional involvement, and the Internet. Overall, attendees thought that the workshop could be effective in facilitating the implementation of a quality improvement project. Conclusion: By considering factors that influence behavioral change, interventions, such as the Society of Hospital Medicine workshop, have the ability to reach and engage clinicians such as hospitalists in quality improvement efforts to prevent antimicrobial resistance and improve adherence to infection control strategies. Furthermore, this study demonstrated that the Health Belief Model can provide an applicable framework for examining factors that influence clinician behavior.
KW - disease control
KW - drug resistance
KW - health care workers
KW - hospitals
KW - human diseases
KW - infection control
KW - infectious diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - Pesticide and Drug Resistance (HH410)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083011424&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4R94C07-9&_user=10&_coverDate=12%2F31%2F2007&_rdoc=9&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236686%232007%23999649989%23675974%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fa27cb777fb93a6059de7c3b8646f4f1
UR - email: AOF4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Implementation of an ergonomics process at a US surface coal mine.
AU - Torma-Krajewski, J.
AU - Steiner, L.
AU - Lewis, P.
AU - Gust, P.
AU - Johnson, K.
A2 - Dempsey, P. G.
T3 - Special Issue: Interventions and case studies in ergonomics and occupational safety.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2007///
VL - 37
IS - 2
SP - 157
EP - 167
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Torma-Krajewski, J.: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA.
N1 - Accession Number: 20083082970. Publication Type: Journal Article. Note: Special Issue: Interventions and case studies in ergonomics and occupational safety. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Since 1990 and the publication of the Ergonomics Program Management Guidelines for Meatpacking Plants by the US Occupational Safety and Health Administration, numerous reports of companies implementing ergonomics program have been published. However, despite these numerous reports, no examples of implementing an ergonomics program in the mining industry have been reported. In 2000, NIOSH initiated a long-term project to demonstrate the implementation of an ergonomics process designed to identify and reduce exposures to ergonomic risk factors found in mining. The mine selected for this project was the Jim Bridger Mine, a surface coal mine located 35 miles northeast of Rock Springs, Sweetwater County, WY. This paper discusses how a large, surface coal mine implemented an ergonomics program and the lessons learned while doing so. Relevance to industry: In 1998, the Mine Safety and Health Administration (MSHA) submitted a formal request to NIOSH to investigate musculoskeletal disorders (MSDs) in the mining industry. In response to MSHA's request, NIOSH initiated a project at the Jim Bridger Mine that involved the implementation of an ergonomics process. This manuscript provides examples of successful interventions as well as recommendations and lessons learned from the implementation of an ergonomics process that will be beneficial to those initiating similar efforts.
KW - coal workers
KW - ergonomics
KW - exposure
KW - health programs
KW - health protection
KW - miners
KW - mining
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - USA
KW - Wyoming
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - USA
KW - Mountain States of USA
KW - Western States of USA
KW - human engineering
KW - United States of America
KW - Health Services (UU350)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083082970&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V31-4MNHXVN-1&_user=6686535&_coverDate=02%2F28%2F2007&_rdoc=9&_fmt=full&_orig=browse&_srch=doc-info(%23toc%235717%232007%23999629997%23642554%23FLA%23display%23Volume)&_cdi=5717&_sort=d&_docanchor=&_ct=12&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=24e8b91345ab6769ff27abb0047c958a
UR - email: jht8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of vibration on grip and push force-recall performance.
AU - McDowell, T. W.
AU - Wiker, S. F.
AU - Dong, R. G.
AU - Welcome, D. E.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2007///
VL - 37
IS - 3
SP - 257
EP - 266
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - McDowell, T. W.: Health Effects Laboratory Division, Engineering and Control Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, M/S 2027, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083082979. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - Comprehensive assessments of health risks associated with the operation of vibratory tools should include evaluations of hand-tool coupling forces. The use of hand-force instrumentation in field applications can be difficult and expensive. A previous study (McDowell, T.W., Wiker, S.F., Dong, R.G., Welcome, D.E., Schopper, A.W., 2006. Evaluation of psychometric estimates of vibratory hand-tool grip and push forces. International Journal of Industrial Ergonomics 36(2), 119-128.) examined various combinations of handle vibration frequencies and grip and push force levels upon one's ability to recall those forces using psychophysical methods. The results of that study were promising. The present study is a follow-up experiment that further investigated the potential for using psychophysical force-recall methods to estimate grip and push forces when operating powered hand tools. In this experiment, 20 subjects (10 male, 10 female) grasped and pushed an instrumented handle for 45 s at one of three force levels while it vibrated sinusoidally at one of four frequencies (16, 31.5, 63, or 125 Hz) or with no vibration. Unlike the first study, two levels of vibration magnitude were examined along with gender differences. This study further clarifies relationships between vibration exposure characteristics and their effects on grip and push force-recall performance. Vibration exposure conditions and other influential factors can be accounted for in enhanced force-recall methodologies that can be incorporated into a variety of workplace exposure assessment applications. Relevance to industry: Workers who are repeatedly exposed to intense hand-transmitted vibration are at risk of developing health problems. To better assess these health risks, hand-tool coupling forces should be evaluated. A refined psychophysical force-recall technique may be a practical alternative to expensive or fragile instrumentation. Before such a method is proposed for laboratory or field applications, an understanding of vibration effects upon force-recall performance must first be explored.
KW - exposure
KW - hand tools
KW - occupational hazards
KW - occupational health
KW - operation
KW - vibration
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Physiology and Biochemistry (VV050)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083082979&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V31-4MVMYWS-1&_user=6686535&_coverDate=03%2F31%2F2007&_rdoc=9&_fmt=full&_orig=browse&_srch=doc-info(%23toc%235717%232007%23999629996%23643820%23FLA%23display%23Volume)&_cdi=5717&_sort=d&_docanchor=&_ct=11&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=2d711c7c2f4a718fe24d6a1fb1ba959c
UR - email: TMcDowell@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological potency of German cockroach allergen extracts determined in an inner city population.
AU - Slater, J. E.
AU - James, R.
AU - Pongracic, J. A.
AU - Liu, A. H.
AU - Sarpong, S.
AU - Sampson, H. A.
AU - Satinover, S. M.
AU - Woodfolk, J. A.
AU - Mitchell, H. E.
AU - Gergen, P. J.
AU - Eggleston, P. A.
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
Y1 - 2007///
VL - 37
IS - 7
SP - 1033
EP - 1039
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0954-7894
AD - Slater, J. E.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20073182152. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 37341-29-0. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Background: Cockroach allergy is an important cause of inner city asthma. To perform valid studies on the diagnosis and treatment of cockroach allergy, biological potencies of test extracts need to be established, and a surrogate in vitro test for biological potency should be chosen. Methods: Sixty-two cockroach-allergic adult subjects were recruited for quantitative skin testing with three commercial German cockroach extracts. The intradermal D50 values were determined using linear interpolation, and the biologic potencies were determined from D50 data. The extracts were also analysed for relative potency, using a competition ELISA, and for specific allergen content, using a two-site ELISA. Results: Estimates of each extract's D50 were analysable in 48-55 subjects, with D50s between 10.3 and 11.8. All three extracts were bioequivalent using pre-set criteria. The biological potencies of the extracts were 1738-8570 bioequivalent allergy units (BAU)/mL (geometric mean=3300), and these relative potencies were similar to those estimated by competition ELISA and specific allergen content. IgE against cockroach allergens were detected in sera from 34 subjects with analysable D50s, and 17 subjects had IgE directed against specific cockroach allergens. Although the presence of anti-Bla g 5 correlated with the subjects' skin test responses for 2/3 extracts, no single allergen was immunodominant. Antibody responses among the subjects were heterogeneous. Conclusions: Although commercial cockroach extracts are relatively low in potency, immunotherapeutic doses should be achievable. Biological potency may be estimated using D50 testing, a combination of specific allergen determinations, or by an overall potency assay such as the competition ELISA. The biological potency of three German cockroach allergen extracts, determined in an inner city population, was 1738-8570 BAU/mL. No one allergen was immunodominant, and surrogate in vitro testing methods were examined.
KW - adults
KW - allergens
KW - arthropod allergies
KW - asthma
KW - extracts
KW - human diseases
KW - IgE
KW - immune response
KW - immunotherapy
KW - potency
KW - skin tests
KW - USA
KW - Blattaria
KW - man
KW - Blattaria
KW - Dictyoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Blattodea
KW - immunity reactions
KW - immunological reactions
KW - intradermal tests
KW - reagin
KW - reaginic antibodies
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073182152&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/cea
UR - email: jay.slater@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vitamin D deficiency in a multinational refugee population.
AU - Wishart, H. D.
AU - Reeve, A. M. F.
AU - Grant, C. C.
JO - Internal Medicine Journal
JF - Internal Medicine Journal
Y1 - 2007///
VL - 37
IS - 12
SP - 792
EP - 797
CY - Melbourne; Australia
PB - Blackwell Publishing
SN - 1444-0903
AD - Wishart, H. D.: Auckland Regional Public Health Service Medical Clinic, Mangere Refugee Resettlement Centre, Manakau City, New Zealand.
N1 - Accession Number: 20083009633. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 1406-16-2. Subject Subsets: Human Nutrition
N2 - Background: Populations with increased skin pigmentation who have migrated to countries of high latitude are at increased risk of low vitamin D. This study aimed to determine the prevalence of low vitamin D among the refugee population arriving in New Zealand. Methods: An audit of all refugees arriving at the national refugee resettlement centre from May 2004 to May 2005 was carried out. Serum 25-hydroxyvitamin D3 levels were measured and defined as normal (50-150 nmol/L) or low, with low subdivided into insufficient (25 to <50 nmol/L) and deficient (<25 nmol/L). Whether vitamin D status varied with age and sex was determined. Results: Vitamin D was measured in 869 (99%) of the refugees and was low in 470 (54%, 95% confidence interval (CI) 51-57%). It was insufficient in 323 (37%, 95%CI 34-41%) and deficient in 147 (17%, 95%CI 15-20%). Female sex was associated with at least a 10 times increased risk of vitamin D deficiency (relative ratio 13.93, 95%CI 10.15-17.96). Women aged between 17 and 45 years and men aged 46 years and more were at greatest risk. Conclusion: Poor vitamin D status is prevalent among refugees arriving in New Zealand. Women, particularly those of child-bearing age are at greatest risk. Screening and ongoing surveillance for vitamin D deficiency should be considered for all recent refugee immigrants to New Zealand.
KW - adults
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - men
KW - nutrition surveys
KW - nutritional state
KW - refugees
KW - vitamin D
KW - vitamin deficiencies
KW - women
KW - New Zealand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - nutritional status
KW - nutritional surveys
KW - vitamin D deficiency
KW - Demography (UU200)
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083009633&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/imj
UR - email: cc.grant@auckland.ac.nz
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of measurement on sex difference in stroke mortality.
AU - Sheikh, K.
AU - Bullock, C. M.
JO - Stroke
JF - Stroke
Y1 - 2007///
VL - 38
IS - 3
SP - 1085
EP - 1087
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0039-2499
AD - Sheikh, K.: US Department of Health and Human Services, Centers for Medicare & Medicaid Services, 601 E. 12th St, Rm 235, Kansas City, MO 64106, USA.
N1 - Accession Number: 20073236566. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - The 1994 to 1997 administrative data on 40 450 elderly Medicare beneficiaries and general population of 2 states were used to measure "case mortality" (deaths attributable to any cause among cases of acute stroke), "case fatality" (deaths caused by cerebrovascular diseases among cases of acute stroke), and "population mortality" (deaths caused by stroke in the elderly general population). Mortality was higher in men than in women according to all measures except population mortality caused by subarachnoid haemorrhage. There was no sex difference in 1-year case fatality. One-year all-cause mortality among cases of nonhemorrhagic stroke or all types of stroke was higher in men than in women. Similar sex differences were found in 4-year population mortality caused by nonhemorrhagic stroke or all types of stroke combined. The 3 measures differed with respect to sex difference in stroke mortality. How stroke is defined and how mortality is measured does affect sex difference.
KW - cerebrovascular disorders
KW - elderly
KW - haemorrhage
KW - human diseases
KW - Medicare
KW - men
KW - mortality
KW - sex differences
KW - stroke
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - bleeding
KW - death rate
KW - elderly people
KW - hemorrhage
KW - older adults
KW - senior citizens
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073236566&site=ehost-live&scope=site
UR - http://stroke.ahajournals.org/cgi/content/full/38/3/1085
UR - email: kazim.sheikh@cms.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Helping consumers make more healthful food choices: consumer views on modifying food labels and providing point-of-purchase nutrition information at quick-service restaurants.
AU - Lando, A. M.
AU - Labiner-Wolfe, J.
T2 - Journal of Nutrition Education and Behavior
JO - Journal of Nutrition Education and Behavior
JF - Journal of Nutrition Education and Behavior
Y1 - 2007///
VL - 39
IS - 3
SP - 157
EP - 163
CY - New York; USA
PB - Elsevier Inc.
SN - 1499-4046
AD - Lando, A. M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20073193614. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology
KW - calories
KW - consumer attitudes
KW - consumer preferences
KW - fast food restaurants
KW - food preferences
KW - labelling
KW - nutrition information
KW - Illinois
KW - Maryland
KW - Pennsylvania
KW - Texas
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Great Plains States of USA
KW - Gulf States of USA
KW - Southern Plains States of USA
KW - West South Central States of USA
KW - Southwestern States of USA
KW - diet preferences
KW - labeling
KW - labels
KW - taste preferences
KW - United States of America
KW - Food Economics (EE116) (New March 2000)
KW - Consumer Economics (EE720)
KW - Food Service (QQ700) (New June 2002)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073193614&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B82X5-4NP4H6X-C-7&_cdi=33021&_user=6686535&_orig=browse&_coverDate=06%2F30%2F2007&_sk=999609996&view=c&wchp=dGLbVlz-zSkzS&md5=31675e99d7e42824538596da6ca1a677&ie=/sdarticle.pdf
UR - email: amy.lando@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Challenges in replicating interventions.
AU - Bell, S. G.
AU - Newcomer, S. F.
AU - Bachrach, C.
AU - Borawski, E.
AU - Jemmott, J. B., III
AU - Morrison, D.
AU - Stanton, B.
AU - Tortolero, S.
AU - Zimmerman, R.
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
Y1 - 2007///
VL - 40
IS - 6
SP - 514
EP - 520
CY - New York; USA
PB - Elsevier
SN - 1054-139X
AD - Bell, S. G.: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073211717. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Purpose - To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. Methods - Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. Results - Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention "to scale" are not discussed. Conclusions - Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations.
KW - adolescents
KW - behaviour
KW - children
KW - community involvement
KW - disease prevention
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - risk behaviour
KW - risk reduction
KW - sexual behaviour
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - human immunodeficiency virus infections
KW - risk behavior
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - teenagers
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Community Participation and Development (UU450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073211717&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T80-4MFTVNC-6&_user=10&_coverDate=06%2F30%2F2007&_rdoc=6&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235072%232007%23999599993%23656925%23FLA%23display%23Volume)&_cdi=5072&_sort=d&_docanchor=&_ct=20&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f1488dcf3df4b7c7ab3339ae1d2b2121
UR - email: newcomes@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Understanding the relative influence of neighborhood, family, and youth on adolescent drug use.
AU - Wright, D. A.
AU - Bobashev, G.
AU - Folsom, R.
JO - Substance Use and Misuse
JF - Substance Use and Misuse
Y1 - 2007///
VL - 42
IS - 14
SP - 2159
EP - 2171
CY - Abingdon; UK
PB - Informa Healthcare
SN - 1082-6084
AD - Wright, D. A.: Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA.
N1 - Accession Number: 20083137421. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing "components of variance" in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative "importance." We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs.
KW - adolescents
KW - cannabis resin
KW - children
KW - drug addiction
KW - families
KW - neighbourhoods
KW - substance abuse
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - neighborhoods
KW - teenagers
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083137421&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a788721006~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - A personal history of veterinary public health in the Pan American Health Organization.
AU - Steele, J. H.
T2 - Veterinaria Italiana
JO - Veterinaria Italiana
JF - Veterinaria Italiana
Y1 - 2007///
VL - 43
IS - 4
SP - 785
EP - 787
CY - Teramo; Italy
PB - Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale'
SN - 0505-401X
AD - Steele, J. H.: United States Public Health Service, The University of Texas-Houston, School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77030, USA.
N1 - Accession Number: 20083033025. Publication Type: Journal Article. Language: English. Language of Summary: Italian. Subject Subsets: Public Health; Medical & Veterinary Entomology; Veterinary Science; Tropical Diseases
KW - aetiology
KW - animal diseases
KW - anthrax
KW - brucellosis
KW - disease control
KW - disease distribution
KW - disease prevalence
KW - disease prevention
KW - disease transmission
KW - disease vectors
KW - domestic animals
KW - epidemiology
KW - organizations
KW - public health
KW - reservoir hosts
KW - spread
KW - tuberculosis
KW - veterinary history
KW - veterinary medicine
KW - wild animals
KW - zoonoses
KW - North America
KW - South America
KW - Bacillus anthracis
KW - Equine encephalomyelitis virus
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - America
KW - animal reservoirs
KW - bacterium
KW - causal agents
KW - etiology
KW - undulant fever
KW - zoonotic infections
KW - History and Biography (BB500)
KW - Agencies and Organizations (DD100)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083033025&site=ehost-live&scope=site
UR - http://www.izs.it
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The joint demand for health care, leisure, and commodities: implications for health care finance and access in Vietnam.
AU - Meyerhoefer, C. D.
AU - Sahn, D. E.
AU - Younger, S. D.
T2 - Journal of Development Studies
JO - Journal of Development Studies
JF - Journal of Development Studies
Y1 - 2007///
VL - 43
IS - 8
SP - 1475
EP - 1500
CY - London; UK
PB - Routledge
SN - 0022-0388
AD - Meyerhoefer, C. D.: Agency for Healthcare Research and Quality, USA.
N1 - Accession Number: 20083035958. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Leisure, Recreation, Tourism; Tropical Diseases; Rural Development
N2 - This paper explores linkages between the demand for health care providers and the consumption of food, non-food goods, and leisure in Vietnam, using a mixed continuous/discrete dependent variable model. Cross-price elasticities calculated from the model suggest there are strong substitution effects between health care, leisure, and certain commodities. The model allows us to explore the implications of replacing user fees with alternative forms of health care finance, such as commodity taxes. In particular, the results suggest financing public health care services with a non-food sales tax rather than user fees would be more progressive and would improve access to care.
KW - commodities
KW - demand
KW - finance
KW - health services
KW - leisure
KW - substitution
KW - taxes
KW - Vietnam
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - Indochina
KW - South East Asia
KW - Asia
KW - taxation
KW - Viet Nam
KW - Health Economics (EE118) (New March 2000)
KW - Leisure, Recreation and Tourism Economics (EE119) (New March 2000)
KW - Supply, Demand and Prices (EE130)
KW - Investment, Finance and Credit (EE800)
KW - Health Services (UU350)
KW - Leisure (UU600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083035958&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a788061351~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement.
AU - Reepmeyer, J. C.
AU - Woodruff, J. T.
T2 - Journal of Pharmaceutical and Biomedical Analysis
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
Y1 - 2007///
VL - 44
IS - 4
SP - 887
EP - 893
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0731-7085
AD - Reepmeyer, J. C.: US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA.
N1 - Accession Number: 20073201216. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 9025-82-5. Subject Subsets: Postharvest Research; Human Nutrition
N2 - An herbal dietary supplement, marketed as a natural product for the enhancement of sexual function, was analyzed by HPLC with photodiode array and mass spectral detection and found to contain a compound related to the synthetic phosphodiesterase-5 (PDE-5) inhibitors. Based on UV spectra, mass spectra and direct infusion MSn, the structure of the compound was tentatively identified as a sildenafil analogue in which the sulfonyl group had been replaced with an acetyl group. This new analogue is similar to acetildenafil, a previously reported sildenafil analogue, but differs in that it contains an N-methyl group where acetildenafil contains an N-ethyl group. The structure of the unknown was unequivocally established by chemical cleavage of the phenacylamine group of the molecule to generate N-methylpiperazine; other cleavage products matched those generated from acetildenafil. Since the new compound has one less CH2 group than acetildenafil, it was named nor-acetildenafil.
KW - adulterants
KW - analogues
KW - analytical methods
KW - chemical reactions
KW - chemical structure
KW - enzyme inhibitors
KW - food supplements
KW - liquid chromatography
KW - mass spectrometry
KW - natural products
KW - phosphodiesterase I
KW - analogs
KW - analytical techniques
KW - sildenafil
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073201216&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07317085
UR - email: john.reepmeyer@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - West Nile virus adheres to human red blood cells in whole blood.
AU - Rios, M.
AU - Daniel, S.
AU - Chancey, C.
AU - Hewlett, I. K.
AU - Stramer, S. L.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007///
VL - 45
IS - 2
SP - 181
EP - 186
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Rios, M.: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073189253. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Background. West Nile virus (WNV) is endemic in the United States. It is transmissible by blood transfusion, and the nation's blood supply is currently screened for WNV. Documented transmission of WNV infection through red blood cell (RBC) units in which the plasma co-component had a low viral load could be explained, in at least 1 instance, by cell-association of WNV; in this case, the RBC unit was released as negative by minipool nucleic acid testing (NAT) performed on plasma but was intermittently NAT-positive when subsequently tested as an individual sample. We hypothesized that a proportion of WNV bound to blood cells and was not measured by NAT performed on plasma samples. We have investigated whether WNV binds to RBCs, leading to reduction of WNV RNA detection by NAT performed on plasma samples. Methods. Equal volumes of leukoreduced RBCs and their corresponding plasma components from 20 blood donors with NAT results that were positive for WNV were tested in 5 replicates by reverse-transcriptase polymerase chain reaction TaqMan for WNV. In addition, aliquots from 8 of the RBC units were tested by infectivity assays using Vero cells. Results. The reverse-transcriptase polymerase chain reaction TaqMan assay showed that the viral load in the RBC components exceeded that in the corresponding plasma units by 1 order of magnitude. In addition, viruses associated with the RBCs were infectious in Vero cell cultures. Conclusions. These observations reinforce the notion that extraction of viral RNA from whole blood could improve assay sensitivity for blood donor screening and further reduce the residual risk of WNV transmission through transfusion.
KW - blood plasma
KW - cytoadherence
KW - erythrocytes
KW - human diseases
KW - in vitro
KW - infectivity
KW - viraemia
KW - viral diseases
KW - viral load
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - blood red cells
KW - cell adhesion
KW - plasma (blood)
KW - red blood cells
KW - viral infections
KW - viremia
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073189253&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/CID/home.html
UR - email: Maria.Rios@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Bacterial endospore inactivation caused by outgassing of vapourous hydrogen peroxide from polymethyl methacrylate (Plexiglas®).
AU - Baron, P. A.
AU - Estill, C. F.
AU - Beard, J. K.
AU - Hein, M. J.
AU - Larsen, L.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2007///
VL - 45
IS - 5
SP - 485
EP - 490
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0266-8254
AD - Baron, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073278266. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 7722-84-1. Subject Subsets: Public Health
N2 - Aims: To investigate the cause and to eliminate the inactivation of Bacillus anthracis strain Sterne spores settled onto agar and stainless steel surfaces in plastic holders. Methods and Results: In an experimental chamber in which spores settled onto sampling surfaces, vapourous hydrogen peroxide (VHP) was used for decontamination between experiments. It was demonstrated that hydrogen peroxide (H2O2) absorbed into plastic (Plexiglas®) surfaces and could outgas in the sample holders. Further experiments demonstrated that H2O2 was released from Plexiglas® sample holders in sufficient quantity to inactivate spores. High temperature degassing (30-35°C) for several days or aluminum coating of the surfaces were two remedies found to be effective in preventing inadvertent spore inactivation. Conclusions: H2O2 can be absorbed into plastic and released after an extended period of time (weeks), allowing a sufficient concentration to accumulate in small volumes to inactivate spores. Outgassing the plastic or coating the surface with an impermeable layer are potential solutions to reduce spore inactivation. Significance and Impact of the Study: Many studies with bacilli and other organisms are carried out using small plastic containers that may have been sterilized using H2O2 or other agents. This study presents a cautionary note to ensure elimination of H2O2 or other sterilizing agents to prevent spurious results.
KW - bacterial spores
KW - decontamination
KW - hydrogen peroxide
KW - inactivation
KW - microbial contamination
KW - plastics
KW - sterilizing
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - polymethyl methacrylate
KW - Environmental Pest Management (HH200)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073278266&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/lam
UR - email: pbaron@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Emerging occupational hazards among Health Care Workers in the new millennium.
AU - Smith, D. R.
AU - Leggat, P. A.
AU - Araki, S.
T2 - Industrial Health
T3 - Occupational hazards among health care workers.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007///
VL - 45
IS - 5
SP - 595
EP - 597
CY - Kawasaki; Japan
PB - National Institute of Industrial Health
SN - 0019-8366
AD - Smith, D. R.: National Institute of Occupational Safety and Health, Japan.
N1 - Accession Number: 20083012347. Publication Type: Journal issue. Note: Occupational hazards among health care workers. Language: English. Number of References: 28 ref. Subject Subsets: Poultry; Tropical Diseases; Public Health
N2 - This supplement contains 12 papers on the epidemiology and management of various occupational hazards among health care workers (HCWs), including nurses, nursing personnel, physicians, dentists in Norway, USA, Italy, Japan and Taiwan. Occupational health problems encountered by HCWs, include low back pain, musculoskeletal disorders, contact dermatitis, avian influenza, job stress and bloodborne diseases. Other topics discussed in this supplement include use of health care services and preparedness of HCWs in the event of an epidemic (avian influenza epidemic).
KW - avian influenza
KW - avian influenza A viruses
KW - avian influenza viruses
KW - contact dermatitis
KW - dentists
KW - epidemics
KW - epidemiology
KW - health care workers
KW - human diseases
KW - influenza viruses
KW - mental stress
KW - musculoskeletal anomalies
KW - nurses
KW - occupational hazards
KW - occupational health
KW - pain
KW - physicians
KW - Italy
KW - Japan
KW - Norway
KW - Taiwan
KW - USA
KW - Influenza A virus
KW - man
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - APEC countries
KW - East Asia
KW - Asia
KW - EFTA
KW - Scandinavia
KW - Northern Europe
KW - South East Asia
KW - North America
KW - America
KW - Avian influenzavirus
KW - bird flu
KW - bird grippe
KW - bird influenza
KW - doctors
KW - emergency preparedness
KW - Formosa
KW - fowl plague virus
KW - Influenzavirus
KW - psychological stress
KW - skeletomuscular anomalies
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083012347&site=ehost-live&scope=site
UR - http://www.niih.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.
AU - Jun HyeSeung
AU - Park TaeSun
AU - Lee ChangKi
AU - Kang MiKyung
AU - Park MiSun
AU - Kang HoIl
AU - Surh YoungJoon
AU - Kim OkHee
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2007///
VL - 45
IS - 5
SP - 708
EP - 715
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Jun HyeSeung: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyong-Gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20073090499. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 404-86-4. Subject Subsets: Public Health; Aromatic & Medicinal Plants; Horticultural Science; Human Nutrition
N2 - Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili peppers, has been reported to possess substantial anticarcinogenic and antimutagenic activities. In the present study, we investigated the effect of capsaicin on induction of apoptosis in highly metastatic B16-F10 murine melanoma cells. Capsaicin inhibited growth of B16-F10 cells in a concentration-dependent manner. Proapoptotic effect of capsaicin was evidenced by nuclear condensation, internucleosomal DNA fragmentation, in situ terminal nick-end labeling of fragmented DNA (TUNEL), and an increased sub G1 fraction. Treatment of B16-F10 cells with capsaicin caused release of mitochondrial cytochrome c, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner. Furthermore, Bcl-2 expression in the B16-F10 cells was slightly down-regulated by capsaicin treatment. In contrast, there were no alterations in the levels of Bax in capsaicin-treated cells. Collectively, these findings indicate that capsaicin-induces apoptosis of B16-F10 melanoma cells via down-regulation the Bcl-2.
KW - apoptosis
KW - capsaicin
KW - cell lines
KW - chillies
KW - human diseases
KW - melanoma
KW - neoplasms
KW - skin cancer
KW - Capsicum
KW - man
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cancers
KW - caspase
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073090499&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: kimkfda@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative measurement of cyanide released from Prussian Blue.
AU - Yang, Y. S.
AU - Brownell, C.
AU - Sadrieh, N.
AU - May, J.
AU - Grosso, A. del
AU - Place, D.
AU - Leutzinger, E.
AU - Duffy, E.
AU - He, R.
AU - Houn, F.
AU - Lyon, R.
AU - Faustino, P.
JO - Clinical Toxicology
JF - Clinical Toxicology
Y1 - 2007///
VL - 45
IS - 7
SP - 776
EP - 781
CY - New York; USA
PB - Informa Healthcare
SN - 1556-3650
AD - Yang, Y. S.: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research, Life Science Building-64, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20083020696. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 74-90-8. Subject Subsets: Public Health
N2 - Background. Prussian Blue (PB), ferric hexacyanoferrate is indicated for oral treatment of internal contamination with radioisotopes of caesium or thallium. Cyanide is 35%-40% of PB's molecular composition, thus cyanide may be released during transit through the digestive tract under physiological pH. The U.S. Food and Drug Administration investigated the issue of cyanide release prior to drug approval to ensure the drug's benefits exceeded risks. Objectives: To determine cyanide released from PB under pH conditions that bracket human physiological exposure. Methods: PB was incubated in situ at pH 1.0-12, 37°C for 1-48 h. Cyanide was measured using a validated colorimetric method by UV-VIS spectroscopy. Results: PB had the highest cyanide release at pH 1 (135 ug/g) and lowest release at pH 5.0-7.0 from the highest daily dose of PB (17.5 g) (21 ug/g). Considering the minimal lethal dose of cyanide is approximately 50 mg, the maximal cyanide released (1.6 mg) does not present a safety concern.
KW - cyanides
KW - hydrogen cyanide
KW - pH
KW - toxic substances
KW - toxicity
KW - hydrocyanic acid
KW - hydrogen ion concentration
KW - poisons
KW - potential of hydrogen
KW - prussic acid
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083020696&site=ehost-live&scope=site
UR - http://journalsonline.tandf.co.uk/link.asp?id=101225
UR - email: patrick.faustino@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Acute toxicity of sodium arsenite in a complex food matrix.
AU - Sprando, R. L.
AU - Collins, T. F. X.
AU - Black, T.
AU - Olejnik, N.
AU - Ramos-Valle, M.
AU - Ruggles, D.
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2007///
VL - 45
IS - 9
SP - 1606
EP - 1613
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Sprando, R. L.: Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20073178355. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7784-46-5. Subject Subsets: Human Nutrition
N2 - Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0 mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0 mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0 mg/kg As in deionized water (41 mg/kg As-water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0 mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41 mg/kg As-water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41 mg/kg As-water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410 mg/kg) was administered in HH however, at lower doses (41 mg/kg), HH reduced acute As oral toxicity in the female and developing fetus.
KW - animal models
KW - fetal development
KW - fetus
KW - food contamination
KW - laboratory animals
KW - maternal effects
KW - mortality
KW - sodium arsenite
KW - toxicity
KW - toxicology
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - foetus
KW - food contaminants
KW - matrocliny
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073178355&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: rsprando@cfsan.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid microsphere assay for identification of Cryptosporidium hominis and Cryptosporidium parvum in stool and environmental samples.
AU - Bandyopadhyay, K.
AU - Kellar, K. L.
AU - Moura, I.
AU - Carollo, M. C. C.
AU - Graczyk, T. K.
AU - Slemenda, S.
AU - Johnston, S. P.
AU - Silva, A. J. da
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2007///
VL - 45
IS - 9
SP - 2835
EP - 2840
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Bandyopadhyay, K.: Scientific Resources Program, National Center for Infectious Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20073268237. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health; Protozoology
N2 - Cryptosporidium hominis and Cryptosporidium parvum are associated with massive disease outbreaks worldwide. Because these two species have different transmission cycles, identification of these parasites to the species level in clinical samples may provide laboratory data of crucial importance in epidemiologic investigations. To date, the most reliable way to differentiate C. hominis and C. parvum is based on DNA sequencing analysis of PCR amplicons. Although this approach is very effective for differentiation of Cryptosporidium species, it is labor-intensive and time-consuming compared with methods that do not require DNA sequencing analysis as an additional step and that have been successfully used for specific identification of a number of pathogens. In this study, we describe a novel Luminex-based assay that can differentiate C. hominis from C. parvum in a rapid and cost-effective manner. The assay was validated by testing a total of 143 DNA samples extracted from clinical specimens, environmental samples, or samples artificially spiked with Cryptosporidium oocysts. As few as 10 oocysts per 300 µl of stools could be detected with this assay. The assay format includes species-specific probes linked to carboxylated Luminex microspheres that hybridize to a Cryptosporidium microsatellite-2 region (ML-2) where C. hominis and C. parvum differ by one nucleotide substitution. The assay proved to be 100% specific when samples that had been characterized by direct fluorescent antibody test (DFA) and DNA sequencing analysis were tested. In addition, the assay was more sensitive than DFA and provided species identification, which is an advantage for epidemiologic studies.
KW - faeces
KW - identification
KW - methodology
KW - Cryptosporidium
KW - Cryptosporidium parvum
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cryptosporidium
KW - Cryptosporidium hominis
KW - feces
KW - methods
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073268237&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: abs8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differentiation of West Nile and St. Louis encephalitis virus infections by use of noninfectious virus-like particles with reduced cross-reactivity.
AU - Roberson, J. A.
AU - Crill, W. D.
AU - Chang, G. J. J.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2007///
VL - 45
IS - 10
SP - 3167
EP - 3174
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Roberson, J. A.: Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20073290854. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Differential diagnosis of St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) infections can be complicated due to the high degree of cross-reactivity observed in most serodiagnostic assays. In an effort to provide a more specific diagnostic test, we developed virus-like particle (VLP) antigens with reduced cross-reactivity for both SLEV and WNV by identifying and mutating envelope protein amino acids within the cross-reactive epitopes of VLP expression plasmids. To determine the serodiagnostic discriminatory ability of the antigens with reduced cross-reactivity, a panel of 134 human serum samples collected predominately from North American patients with SLEV or WNV infections was used to evaluate the performance of these novel antigens in immunoglobulin M antibody-capture enzyme-linked immunosorbent assays. Positive/negative ratios and the resulting diagnostic classifications were compared between the mutant and the wild-type (WT) VLPs. The mutant VLP antigens were more specific, with higher positive predictive values and higher likelihood ratios than the WT VLP antigens. Both the SLEV and WNV mutant VLPs greatly reduced the observed cross-reactivity, significantly increasing the specificity and sensitivity of the assay. The use of these novel VLP antigens with reduced cross-reactivity in these serodiagnostic assays and others should lead to more accurate diagnoses of current infections, thereby reducing the need for time-consuming and cumbersome confirmatory plaque-reduction neutralization tests to differentiate between SLEV and WNV infections in North America.
KW - antigens
KW - cross reaction
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - St Louis encephalitis
KW - West Nile fever
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - immunogens
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073290854&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: gxc7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ensuring access to treatment for HIV infection.
AU - Cheever, L. W.
AU - Lubinski, C.
AU - Horberg, M.
AU - Steinberg, J. L.
A2 - Bartlett, J. G.
A2 - Mayer, K. H.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007///
VL - 45
IS - Suppl.4
SP - S266
EP - S274
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Cheever, L. W.: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Ste. 7-05, 5600 Fishers Ln., Rockville, MD 20857, USA.
N1 - Accession Number: 20073298723. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - The recent recommendations of the Centers for Disease Control and Prevention for opt-out testing are intended to address the evolving human immunodeficiency virus (HIV) epidemic in the United States by bringing more HIV-infected individuals into medical care. This is an important step to better control the epidemic but brings with it the challenges of adequately caring for more individuals infected with HIV and of funding medications and medical care for these additional patients. With more patients being offered HIV testing, there will be a surge in the need for testing and counseling services, which must keep pace with patient demand. This article describes the current status of HIV screening and care from 4 perspectives: the Ryan White Program (previously known as the Ryan White Comprehensive AIDS Resources Emergency Act), Medicaid and Medicare reimbursement for HIV screening, a managed care organization, and community health centers. The mandate for routine HIV screening challenges each of these health care entities, but all will need to overcome these challenges if routine HIV screening is to become a reality.
KW - antiretroviral agents
KW - antiviral agents
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - scarecrows
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073298723&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/522549
UR - email: Lcheever@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parvovirus B19 DNA in Factor VIII concentrates: effects of manufacturing procedures and B19 screening by nucleic acid testing.
AU - Geng, Y. S.
AU - Wu, C. G.
AU - Bhattacharyya, S. P.
AU - Tan, D.
AU - Guo, Z. P.
AU - Yu, M. Y. W.
JO - Transfusion
JF - Transfusion
Y1 - 2007///
VL - 47
IS - 5
SP - 883
EP - 889
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Geng, Y. S.: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073158693. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 9007-49-2, 113189-02-9. Subject Subsets: Public Health
N2 - Background: Parvovirus B19 (B19) is a common contaminant of blood transfusion products. Because of the report of B19 transmission through pooled plasma in 1999, some fractionators have initiated minipool nucleic acid testing (NAT) to limit the B19 load in manufacturing pools. This study investigated the extent of B19 DNA contamination in commercial factor VIII concentrates (human antihemophilic factor (AHF)) manufactured before and after the B19 NAT screening was implemented. Methods: A total of 284 lots representing six US-licensed AHF products made during 1993-1998 and 2001-2004 were assayed for B19 DNA by an in-house NAT method. Anti-B19 IgG was also measured. Results: Most lots made during 1993-1998 had detectable B19 DNA. The prevalence ranged from 56 to 100%, and appeared to differ between manufacturers. The highest level of B19 DNA found was 106 genome equivalents (geq or international units (IU)) per ml. Forty percent of the lots tested contained 103 geq (IU) per mL. In comparison, both prevalence and levels in source plasma-derived AHF products made during 2001-2004 were lower. Both, however, remained unchanged in the recovered plasma-derived product because B19 NAT screening had not been implemented. Only an intermediate-purity AHF product was positive for the presence of anti-B19 IgG. Conclusion: The prevalence and levels of B19 DNA in AHF prepared from B19 NAT unscreened plasma were high but varied among products with different manufacturing procedures. B19 NAT screening of plasma effectively lowered the B19 DNA level in the final products and in the majority of cases rendered it undetectable and hence potentially reduced the risk of B19 transmission.
KW - blood plasma
KW - blood products
KW - DNA
KW - factor VIII
KW - microbial contamination
KW - quality controls
KW - screening
KW - viral load
KW - USA
KW - Parvovirus B19
KW - Parvovirus
KW - Parvoviridae
KW - ssDNA viruses
KW - DNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - deoxyribonucleic acid
KW - plasma (blood)
KW - quality assurance
KW - screening tests
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073158693&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/trf
UR - email: mei-ying.yu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anticonvulsant mechanisms of the ketogenic diet.
AU - Bough, K. J.
AU - Rho, J. M.
JO - EPILEPSIA
JF - EPILEPSIA
Y1 - 2007///
VL - 48
IS - 1
SP - 43
EP - 58
CY - Boston; USA
PB - Blackwell Publishing
SN - 0013-9580
AD - Bough, K. J.: Center for Drug Evaluation & Research, Food and Drug Administration, MPN 1 - Room 1345, 7520 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20073140655. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 50-99-7. Subject Subsets: Public Health; Human Nutrition
N2 - The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy. Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain unknown. In this review, we present one intersecting view of how the KD may exert its anticonvulsant activity against the backdrop of several seemingly disparate mechanistic theories. We summarize key insights gleaned from experimental and clinical studies of the KD, and focus particular attention on the role that ketone bodies, fatty acids, and limited glucose may play in seizure control. Chronic ketosis is anticipated to modify the tricarboxcylic acid cycle to increase GABA synthesis in brain, limit reactive oxygen species (ROS) generation, and boost energy production in brain tissue. Among several direct neuro-inhibitory actions, polyunsaturated fatty acids increased after KD induce the expression of neuronal uncoupling proteins (UCPs), a collective up-regulation of numerous energy metabolism genes, and mitochondrial biogenesis. These effects further limit ROS generation and increase energy production. As a result of limited glucose and enhanced oxidative phosphorylation, reduced glycolytic flux is hypothesized to activate metabolic KATP channels and hyperpolarize neurons and/or glia. Although it is unlikely that a single mechanism, however well substantiated, will explain all of the diet's clinical benefits, these diverse, coordinated changes seem poised to stabilize synaptic function and increase the resistance to seizures throughout the brain.
KW - anticonvulsant properties
KW - brain
KW - energy metabolism
KW - epilepsy
KW - free radicals
KW - glucose
KW - human diseases
KW - ketone bodies
KW - neurons
KW - polyenoic fatty acids
KW - therapeutic diets
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anti-convulsant properties
KW - anti-epileptic properties
KW - cerebrum
KW - dextrose
KW - diet therapy
KW - ketogenic diet
KW - nerve cells
KW - neurones
KW - polyunsaturated fatty acids
KW - special diets
KW - therapeutic nutrition
KW - uncoupling protein
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073140655&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=epi
UR - email: Kristopher.Bough@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A probabilistic framework for non-cancer risk assessment.
AU - Chen, J. J.
AU - Moon, H. J.
AU - Kodell, R. L.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2007///
VL - 48
IS - 1
SP - 45
EP - 50
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Chen, J. J.: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073236770. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Risk assessment involves an analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level or to estimate a low-dose risk. Acceptable levels of human exposure for non-cancer effects generally are derived by dividing an experimental no-observed-adverse-effect-level or a lower confidence limit benchmark dose by a product of several uncertainty factors. This paper presents a hierarchical modelling framework for a probabilistic approach to non-cancer risk assessment. The hierarchical model integrates the distributions of uncertainty factors and the distribution of the actual exposure level to construct the dose - response model for the proportion of population at risk and the dose - response model for the expected proportion of population at risk for a given exposure distribution. The proposed approach is based on the use of the BMDL (lower confidence limit on the benchmark dose) as a POD (point of departure) for risk assessment of non-cancer effects.
KW - distribution
KW - exposure
KW - risk assessment
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073236770&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4MJJCC9-1&_user=10&_coverDate=06%2F30%2F2007&_rdoc=7&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236999%232007%23999519998%23658719%23FLA%23display%23Volume)&_cdi=6999&_sort=d&_docanchor=&view=c&_ct=14&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7e1b5004602048a3393005c3eafe25cd
UR - email: jchen@nctr.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lead in pharmaceutical products and dietary supplements.
AU - Kauffman, J. F.
AU - Westenberger, B. J.
AU - Robertson, J. D.
AU - Guthrie, J.
AU - Jacobs, A.
AU - Cummins, S. K.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2007///
VL - 48
IS - 2
SP - 128
EP - 134
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Kauffman, J. F.: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, USA.
N1 - Accession Number: 20073227254. Publication Type: Journal Article. Language: English. Registry Number: 7439-92-1.
N2 - The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products. Lead concentrations of 45 products were measured with inductively-coupled plasma mass spectrometry. Six products had lead concentrations greater than 100 parts per billion (ppb), and the highest measured concentration was 500 ppb. The average mass of lead delivered to consumers by all products examined in this study when taken as directed was 0.22 micrograms per day, which is expected to increase the blood lead level of an adult by less than 1%. Five products were found to deliver more than 1 µg of lead per day when used as directed. Current tolerable lead limits in pharmaceutical substances vary widely, and in some cases exceed 10,000 ppb. The products examined in this study have lead concentrations far below these levels. However, in light of recent research demonstrating adverse effects in both children and adults from low level lead exposure, current lead limits for pharmaceutical substances are unacceptably high. Uniform lead limits that reflect current manufacturing capabilities are needed to insure the lowest achievable exposure to lead from these products.
KW - adverse effects
KW - blood
KW - children
KW - consumers
KW - diets
KW - food supplements
KW - lead
KW - mass spectrometry
KW - pharmaceutical products
KW - supplements
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - Human Nutrition (General) (VV100)
KW - Food Additives (QQ130)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073227254&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4NC390F-1&_user=10&_coverDate=07%2F31%2F2007&_rdoc=4&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236999%232007%23999519997%23659453%23FLA%23display%23Volume)&_cdi=6999&_sort=d&_docanchor=&view=c&_ct=10&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0877136c664157c449f3585bd4d907b3
UR - email: John.Kauffman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential work-related bloodborne pathogen exposures by industry and occupation in the United States. Part I: An emergency department-based surveillance study.
AU - Chen, G. X.
AU - Jenkins, E. L.
A2 - Persson, B.
T3 - Special Issue: Ethical considerations and future challenges in occupational and environmental health.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007///
VL - 50
IS - 3
SP - 183
EP - 190
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Chen, G. X.: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 20083044120. Publication Type: Journal Article. Note: Special Issue: Ethical considerations and future challenges in occupational and environmental health. Language: English. Subject Subsets: Public Health
N2 - Background: Since the early 1990s, researchers have attempted to assess the magnitude of potential work-related bloodborne pathogen (BBP) exposures in the U.S. The only data-derived estimate of 385,000 needlestick and other sharps injuries per year was reported in 2004. The estimate was derived from a convenience sample and did not include exposures outside of hospitals. This study seeks to understand the magnitude and distribution of the exposures across all industries and occupations. Methods: Data were from the 1998 to 2000 National Electronic Injury Surveillance System (NEISS), a stratified probability-based sample of U.S. hospital emergency departments (EDs). NEISS covers all industries and occupations. National estimates of exposures and exposure rates (the number of exposures/1,000 full-time equivalents (FTE)) were computed. Results: An estimated 78,100 potential work-related exposures to BBP were treated in hospital EDs annually in the U.S. While hospitals accounted for 75% of all these exposures, 11 other industries had a substantial number of exposures. While registered nurses accounted for 36% of all exposures, 13 other occupations had a substantial number of exposures. Hospitals had the highest exposure rate of 11.3/1,000 FTE, followed by nursing homes (2.8), and residential care facilities without nursing (1.9). Registered nurses had the highest exposure rate of 15.3/1,000 FTE, followed by clinical laboratory technologists and technicians (13.9), and physicians (7.1). Conclusions: While this study begins to more completely describe the problem of potential BBP exposure in the workplace, it is but a first step in further understanding the complex issues surrounding workplace BBP exposures.
KW - blood
KW - disease incidence
KW - epidemiology
KW - exposure
KW - health care workers
KW - hospitals
KW - human diseases
KW - infectious diseases
KW - nurses
KW - occupational hazards
KW - occupational health
KW - occupational transmission
KW - physicians
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - doctors
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044120&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114113842/ABSTRACT
UR - email: gchen@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rayon flock: a new cause of respiratory morbidity in a card processing plant.
AU - Antao, V. C. S.
AU - Piacitelli, C. A.
AU - Miller, W. E.
AU - Pinheiro, G. A.
AU - Kreiss, K.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007///
VL - 50
IS - 4
SP - 274
EP - 284
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Antao, V. C. S.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road - MS G900.2, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083044129. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Following employee respiratory concerns, we investigated the health effects of rayon flock exposure at a card manufacturing plant. Methods: We conducted a cross-sectional survey including environmental evaluation, standardized questionnaires, spirometry, carbon monoxide diffusing capacity testing, and methacholine challenge testing. Results: From a total of 239 participants, 146 (61%) reported working at least 1 hr per week in areas where flock-coated cards are processed ("flock workers") and 47 (20%) reported cleaning equipment with compressed air. These workers had generally higher prevalences of respiratory symptoms. Flock workers and employees with longer tenure at areas where flock-coated cards are processed were more likely to have restrictive impairment of lung function. Although dust and fiber samples were largely below the detection limits, peak exposures to airborne particulate occurred during cleaning with compressed air. Conclusions: Working with rayon flock and cleaning with compressed air were associated with health effects in workers at this plant.
KW - dust
KW - human diseases
KW - industrial workers
KW - lung function
KW - occupational hazards
KW - occupational health
KW - rayon
KW - respiratory diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lung diseases
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044129&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114188932/ABSTRACT
UR - email: vinicius.antao@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential work-related exposures to bloodborne pathogens by industry and occupation in the United States Part II: a telephone interview study.
AU - Chen, G. X.
AU - Jenkins, E. L.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007///
VL - 50
IS - 4
SP - 285
EP - 292
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Chen, G. X.: National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, MS/1811, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083044130. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: The companion surveillance portion of this study [Chen and Jenkins, 2007] reported the frequency and rate of potential work-related exposures to bloodborne pathogens (BBP) treated in emergency departments (EDs) by industry and occupation, but it lacks details on the circumstances of the exposure and other relevant issues such as BBP safety training, use of personal protective equipment (PPE) or safety needles, or reasons for seeking treatment in a hospital ED. Methods: Telephone interviews were conducted with workers who had been treated in EDs for potential work-related exposures to BBP in 2000-2002. Respondents were drawn from the National Electronic Injury Surveillance System. Results: Of the 593 interviews, 382 were from hospitals, 51 were from emergency medical service/firefighting (EMS/FF), 86 were from non-hospital healthcare settings (e.g., nursing homes, doctors' offices, home healthcare providers, etc.), 22 were from law enforcement (including police and correctional facilities), and 52 were from other non-healthcare settings (i.e., schools, hotels, and restaurants). Needlestick/sharps injuries were the primary source of exposure in hospitals and non-hospital healthcare settings. Skin and mucous membrane was the primary route of exposure in EMS/FF. Human bites accounted for a significant portion of the exposures in law enforcement and other non-healthcare settings. In general, workers from non-hospital settings were less likely to use PPE, to have BBP safety training, to be aware of the BBP standards and exposure treatment procedures, and to report or seek treatment for a work-related exposure compared to hospital workers. Conclusions: This study suggests that each industry group has unique needs that should be addressed.
KW - bites
KW - health care workers
KW - human diseases
KW - infectious diseases
KW - needlestick injuries
KW - occupational hazards
KW - occupational health
KW - occupational transmission
KW - pathogens
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044130&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114171238/ABSTRACT
UR - email: gchen@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in workplace homicides in the U.S., 1993-2002: a decade of decline.
AU - Hendricks, S. A.
AU - Jenkins, E. L.
AU - Anderson, K. R.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007///
VL - 50
IS - 4
SP - 316
EP - 325
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Hendricks, S. A.: National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083044131. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Trends in workplace homicide rates are compared to the trends in U.S. homicides from 1993 to 2002, inclusively. The homogeneity of workplace homicide rates by victim demographics, circumstances, and types of events are also addressed. Methods: Using publicly available data from several sources, Poisson models are used to statistically compare the trends of workplace homicide rates versus U.S. homicide rates and to compare trends within categories of workplace homicides. Results: Overall, there was a significant decline in the rates of occupational homicide of approximately 6% per year during the study time period; this decline was found to be statistically greater than the decline of all U.S. homicides (5% per year). Taxi cab drivers and chauffeurs demonstrated the greatest decline of all occupational subgroups. When looking at the circumstances of workplace homicides, only the rate of homicides committed during a robbery or other crime demonstrated a significant decline. Conclusions: While workplace homicides have declined in the U.S., the declines have not occurred uniformly across demographic and occupational categories.
KW - crime
KW - epidemiology
KW - safety at work
KW - trends
KW - work places
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - homicides
KW - occupational safety
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044131&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114188928/ABSTRACT
UR - email: sah5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Floodwater exposure and the related health symptoms among firefighters in New Orleans, Louisiana 2005.
AU - Tak, S. W.
AU - Bernard, B. P.
AU - Driscoll, R. J.
AU - Dowell, C. H.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007///
VL - 50
IS - 5
SP - 377
EP - 382
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Tak, S. W.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-10, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083044141. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Concerns over increased reports of physical health symptoms thought to be related to floodwater exposure among New Orleans firefighters prompted a health hazard evaluation of firefighters following Hurricane Katrina. Methods: A questionnaire assessing health symptoms possibly related to the response to Hurricane Katrina was administered to all New Orleans Fire Department (NOFD) personnel within 3 months of the disaster. Descriptive statistics were compiled and prevalence ratios (PR) were estimated for covariates using generalized linear models with Log link and Poisson distribution. Results: Of the 525 firefighters who completed the questionnaire (77% participation), 201 (38%) reported one or more new-onset respiratory symptoms, such as sinus congestion (145 [28%]), throat irritation (92 [17%]), and cough (124 [24%]). Skin rash was reported by 258 (49%) of respondents, 414 (79%) reported skin contact with floodwater, and 165 (32%) reported contact with floodwater on multiple days. In multivariate analyses adjusting for age, gender, and smoking, firefighters who had floodwater contact with skin and either nose/mouth or eyes (224, 44%) had an increased rate of new-onset upper respiratory symptoms (PR=1.9; 95% confidence interval [CI], 1.1, 3.1), and skin rash (PR=2.1; 95% CI, 1.4, 3.2) compared to those not exposed to the floodwater. Conclusions: Response workers involved with floodwater should minimize direct skin and mucosal contact with floodwater if possible through the use of appropriate personal protective equipment, such as goggles, safety glasses with side shields, or full-face shields.
KW - cough
KW - exposure
KW - fire fighters
KW - floods
KW - health
KW - human diseases
KW - hurricanes
KW - natural disasters
KW - occupational hazards
KW - occupational health
KW - respiratory diseases
KW - skin diseases
KW - symptoms
KW - Louisiana
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Gulf States of USA
KW - West South Central States of USA
KW - dermatoses
KW - firemen
KW - lung diseases
KW - United States of America
KW - Natural Disasters (PP800)
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044141&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114205981/ABSTRACT
UR - email: STak@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in Iowa.
AU - Curwin, B. D.
AU - Hein, M. J.
AU - Sanderson, W. T.
AU - Striley, C.
AU - Heederik, D.
AU - Kromhout, H.
AU - Reynolds, S. J.
AU - Alavanja, M. C.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2007///
VL - 51
IS - 1
SP - 53
EP - 65
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - Curwin, B. D.: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio, USA.
N1 - Accession Number: 20073104390. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 1912-24-9, 2921-88-2, 38641-94-0, 1071-83-6, 70393-85-0, 51218-45-2. Subject Subsets: Agricultural Entomology; Public Health; Medical & Veterinary Entomology; Weeds
N2 - In the spring and summer of 2001, 47 fathers, 48 mothers and 117 children of Iowa farm and non-farm households were recruited to participate in a study investigating take-home pesticide exposure. On two occasions ~1 month apart, urine samples from each participant and dust samples from various rooms were collected from each household and were analyzed for atrazine, metolachlor, glyphosate and chlorpyrifos or their metabolites. The adjusted geometric mean (GM) level of the urine metabolite of atrazine was significantly higher in fathers, mothers and children from farm households compared with those from non-farm households (P≤0.0001). Urine metabolites of chlorpyrifos were significantly higher in farm fathers (P=0.02) and marginally higher in farm mothers (P=0.05) when compared with non-farm fathers and mothers, but metolachlor and glyphosate levels were similar between the two groups. GM levels of the urinary metabolites for chlorpyrifos, metolachlor and glyphosate were not significantly different between farm children and non-farm children. Farm children had significantly higher urinary atrazine and chlorpyrifos levels (P=0.03 and P=0.03 respectively) when these pesticides were applied by their fathers prior to sample collection than those of farm children where these pesticides were not recently applied. Urinary metabolite concentration was positively associated with pesticide dust concentration in the homes for all pesticides except atrazine in farm mothers; however, the associations were generally not significant. There were generally good correlations for urinary metabolite levels among members of the same family.
KW - atrazine
KW - children
KW - chlorpyrifos
KW - exposure
KW - farms
KW - fathers
KW - glyphosate
KW - herbicides
KW - insecticides
KW - metabolites
KW - metolachlor
KW - mothers
KW - urine
KW - Iowa
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - chlorpyrifos-ethyl
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073104390&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/
UR - email: bcurwin@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variation in the WBC differential count and other factors associated with reporting of herpes labialis: a population-based study of adults.
AU - Parks, C. G.
AU - Andrew, M. E.
AU - Blanciforti, L. A.
AU - Luster, I. I.
JO - FEMS Immunology and Medical Microbiology
JF - FEMS Immunology and Medical Microbiology
Y1 - 2007///
VL - 51
IS - 2
SP - 336
EP - 343
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0928-8244
AD - Parks, C. G.: Biostatistics and Epidemiology Branch and Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083130788. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Reactivation of latent herpes virus has been linked to triggers of mild immunosuppression, such as stress or UV-exposure. Despite having predictive value in severe immunodeficiency, the white blood cell (WBC) differential count has not been examined in relation to risk of herpes reactivation in population studies. The WBC differential count and other risk factors for herpes labialis were examined in 5687 adults (ages 18-64) from the Third National Health and Nutrition Examination Survey, who had WBC 3.5-11×106 cells mL-1 and reported no acute infections in the past month. The association between self-reported herpes labialis in the past year and the WBC differential count was modeled, adjusting for age, sex, race/ethnicity, education, smoking, upper respiratory infections (URI), and HSV-1 antibodies. Herpes labialis was significantly associated with white race/ethnicity, being a nonsmoker, and frequent URI. Compared with the highest quartile, being in the lowest quartile of granulocytes was associated with herpes labialis, adjusted odds ratio=1.82 (95% confidence interval 1.20, 2.28). At the same time, there was a trend towards an inverse association of lower lymphocyte count and herpes labialis. These findings suggest that moderate differences in the WBC differential count are related to reactivation of HSV-1. Prospective studies may help to show whether such differences indicate susceptibility to loss of latency or represent a consequence of reactivated infection.
KW - adults
KW - data collection
KW - ethnic groups
KW - granulocytes
KW - herpes simplex
KW - human diseases
KW - latent infections
KW - leukocytes
KW - lips
KW - lymphocytes
KW - respiratory diseases
KW - risk factors
KW - viral diseases
KW - whites
KW - USA
KW - Human herpesvirus 1
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Simplexvirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - data logging
KW - leucocytes
KW - lung diseases
KW - respiratory tract infections
KW - United States of America
KW - viral infections
KW - white blood cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083130788&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1574-695X.2007.00314.x
UR - email: cqp8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating fungal populations by genera/species on wide body commercial passenger aircraft and in airport terminals.
AU - McKernan, L. T.
AU - Burge, H.
AU - Wallingford, K. M.
AU - Hein, M. J.
AU - Herrick, R.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2007///
VL - 51
IS - 3
SP - 281
EP - 291
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - McKernan, L. T.: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073211236. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Medical & Veterinary Mycology; Weeds; Leisure, Recreation, Tourism
N2 - Given the potential health effects of fungi and the amount of time aircrew and passengers spend inside aircraft, it is important to study fungal populations in the aircraft environment. Research objectives included documenting the genera/species of airborne culturable fungal concentrations and total spore concentrations on a twin-aisle wide body commercial passenger aircraft. Twelve flights between 4.5 and 6.5 h in duration on Boeing 767 (B-767) aircraft were evaluated. Two air cooling packs and 50% recirculation rate (i.e. 50:50 mix of outside air and filtered inside air) were utilized during flight operations. Passenger occupancy rates varied from 67 to 100%. N-6 impactors and total spore traps were used to collect sequential, triplicate air samples in the front and rear of coach class during six sampling intervals throughout each flight: boarding, mid-climb, early cruise, mid-cruise, late cruise and deplaning. Comparison air samples were also collected inside and outside the airport terminals at the origin and destination cities resulting in a total of 522 culturable and 517 total spore samples. A total of 45 surface wipe samples were collected using swabs onboard the aircraft and inside the airport terminals. A variety of taxa were observed in the culturable and total spore samples. A frequency analysis of the fungal data indicated that Cladosporium, Aspergillus and Penicillium were predominant genera in the culturable samples whereas Cladosporium, Basidiospores and Penicillium/Aspergillus were predominant in the total spore samples. Fungal populations observed inside the aircraft were comprised of similar genera, detected significantly less frequently and with lower mean concentrations than those observed in typical office buildings. Although sources internal to the aircraft could not be ruled out, our data demonstrate the importance of passenger activity as the source of the fungi observed on aircraft. Isolated fungal peak events occurred occasionally when concentrations of a particular genus or species rose sharply inside the cabin for a limited period. Overall, our research demonstrates that on the sampled flights the B-767 filtration system operated efficiently to remove fungal spores when two air cooling packs and 50% recirculation rate were utilized during flight operations.
KW - air spora
KW - air transport
KW - aircraft
KW - airports
KW - basidiospores
KW - fungal spores
KW - microbial contamination
KW - terminal facilities
KW - transport
KW - Aspergillus
KW - Cladosporium
KW - Penicillium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Basidiomycota
KW - Davidiellaceae
KW - Capnodiales
KW - Dothideomycetes
KW - airfields
KW - Basidiomycotina
KW - fungus
KW - Hyphomycetes
KW - transportation
KW - Weeds and Noxious Plants (FF500)
KW - Tourism and Travel (UU700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073211236&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/
UR - email: LMcKernan@CDC.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli.
AU - Elkins, C. A.
AU - Mullis, L. B.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2007///
VL - 51
IS - 3
SP - 923
EP - 929
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Elkins, C. A.: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20073084176. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent structural studies to bind substrates at multiple sites, suggesting that particular substrate "sets" may compete for efflux by interfering with a certain binding site(s). However, our data indicate that the general structural class does not appear to dictate a particular substrate binding site that can be competitively inhibited in whole cells. In our study, substrate competition failed to increase cell-associated levels of steroids or dyes to levels characteristic of AcrB- or AcrB/EmrAB-deficient genomic mutants or achieved with the pump inhibitor carbonyl cyanide m-chlorophenylhydrazone. In addition, this general observation was sustained even with (i) a cocktail containing seven-pump substrates supplied slightly below their respective wild-type MIC levels, (ii) competing drug substrates of the same structural class (steroids or macrolides), and (iii) hyper-MIC levels of the exogenously supplied agents. Thus, this pump system (and possibly EmrAB-TolC) may have an extraordinary capacity to simultaneously handle multiple-drug substrates that is not necessarily reflected in MIC analyses. In addition, our study has extended the range of substrates recognized by the AcrAB- and EmrAB-TolC systems.
KW - antibacterial agents
KW - assays
KW - bacterial diseases
KW - molecular biology
KW - multiple drug resistance
KW - resistance mechanisms
KW - substrates
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073084176&site=ehost-live&scope=site
UR - http://aac.asm.org/
UR - email: chris.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of essential oils from three plants for enhancement of antimicrobial activity of nitrofurantoin against enterobacteria.
AU - Rafii, F.
AU - Shahverdi, A. R.
JO - Chemotherapy (Basel)
JF - Chemotherapy (Basel)
Y1 - 2007///
VL - 53
IS - 1
SP - 21
EP - 25
CY - Basel; Switzerland
PB - S Karger AG
SN - 0009-3157
AD - Rafii, F.: National Center for Toxicological Research, US FDA, Jefferson, Arizona, USA.
N1 - Accession Number: 20083065914. Publication Type: Journal Article. Language: English. Registry Number: 464-49-3, 76-22-2, 2244-16-8, 99-49-0, 138-86-3. Subject Subsets: Botanical Pesticides; Aromatic & Medicinal Plants
N2 - Piperitone from plant essential oils enhances bactericidal activities of nitrofurantoin and furazolidone against bacteria from the family Enterobacteriaceae. In this study, the essential oils of spearmint (Mentha spicata), dill (Anethum graveolens) and peppermint (Mentha piperita) were screened for augmentation of nitrofurantoin activity and the most active components were determined. The effects of essential oils and their components on the bactericidal activity of nitrofurantoin against Enterobacter cloacae were studied using disk-diffusion and agar-dilution methods. The composition of essential oils was studied using gas chromatography-mass spectrometry. M. spicata and A. graveolens oils exhibited the highest effects. Gas chromatography-mass spectrometry analysis showed that the oils of these 2 plants contained 40.12 and 20.32% carvone, respectively. Pure carvone and piperitone equally increased the bactericidal activity of nitrofurantoin. Other ingredients of essential oils, including camphor, limonene and menthone, were less effective.
KW - antibacterial properties
KW - camphor
KW - carvone
KW - chemical composition
KW - dill
KW - essential oil plants
KW - essential oils
KW - limonene
KW - Anethum graveolens
KW - Enterobacter cloacae
KW - Mentha piperita
KW - Mentha spicata
KW - plants
KW - Anethum
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Mentha
KW - Lamiaceae
KW - Lamiales
KW - Araliales
KW - bactericidal properties
KW - bacterium
KW - essential oil crops
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083065914&site=ehost-live&scope=site
UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=98246&Ausgabe=232774&ProduktNr=223834
UR - email: shahverd@sina.tums.ac.ir
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An international review of tobacco smoking among medical students.
AU - Smith, D. R.
AU - Leggat, P. A.
JO - Journal of Postgraduate Medicine
JF - Journal of Postgraduate Medicine
Y1 - 2007///
VL - 53
IS - 1
SP - 55
EP - 62
CY - Mumbai; India
PB - Medknow Publications
SN - 0022-3859
AD - Smith, D. R.: Japan National Institute of Occupational Safety and Health, Kawasaki, Japan.
N1 - Accession Number: 20073134790. Publication Type: Journal Article. Language: English. Number of References: 93 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - We conducted a systematic international review of tobacco smoking habits among medical students. Particular attention was paid to countries where smoking rates have been historically well-documented in local journals, but were less often included in larger international review articles. The methodology involved a search of relevant medical subject headings, after which the reference lists of journal papers were also examined to find additional publications. A total of 66 manuscripts met the inclusion criteria. The most common countries previously studied included India, the United States, Australia, Japan, Pakistan, Turkey and the United Kingdom. Overall, our review suggests that the prevalence of smoking among medical students varies widely amongst different countries and also between male and female students within the same areas. Consistently low smoking rates were found in Australia and the United States, while generally high rates were reported in Spain and Turkey. Given their important future role as exemplars, more effective measures to help reduce tobacco smoking among medical students are clearly needed worldwide.
KW - medical students
KW - men
KW - sex differences
KW - systematic reviews
KW - tobacco smoking
KW - women
KW - Australia
KW - India
KW - Japan
KW - Pakistan
KW - Spain
KW - Turkey
KW - UK
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Developing Countries
KW - South Asia
KW - Asia
KW - East Asia
KW - European Union Countries
KW - Mediterranean Region
KW - Southern Europe
KW - Europe
KW - West Asia
KW - British Isles
KW - Western Europe
KW - North America
KW - America
KW - Britain
KW - United Kingdom
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073134790&site=ehost-live&scope=site
UR - http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2007;volume=53;issue=1;spage=55;epage=62;aulast=Smith
UR - email: smith@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Acetylation and nitrosation of ciprofloxacin by environmental strains of mycobacteria.
AU - Adjei, M. D.
AU - Heinze, T. M.
AU - Deck, J.
AU - Freeman, J. P.
AU - Williams, A. J.
AU - Sutherland, J. B.
T2 - Canadian Journal of Microbiology
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2007///
VL - 53
IS - 1
SP - 144
EP - 147
CY - Ottawa; Canada
PB - National Research Council of Canada
SN - 0008-4166
AD - Adjei, M. D.: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073155188. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 32 ref. Registry Number: 85721-33-1. Subject Subsets: Public Health
N2 - To determine the ability of environmental bacteria to metabolize the frequently prescribed fluoroquinolone drug ciprofloxacin, eight Mycobacterium spp. cultures were grown for 4 days in a medium containing sorbitol and yeast extract with 100 mg-L-1 ciprofloxacin. After the cultures had been centrifuged and the supernatants extracted with ethyl acetate, two metabolites were purified by using high-performance liquid chromatography. They were identified with liquid chromatography/electrospray ionization mass spectrometry and proton nuclear magnetic resonance spectroscopy. Ciprofloxacin was transformed to both N-acetylciprofloxacin (2.5%-5.5% of the total peak area at 280 nm) and N-nitrosociprofloxacin (6.0%-8.0% of the peak area) by Mycobacterium gilvum PYR-GCK and Mycobacterium sp. PYR100 but it was transformed only to N-acetylciprofloxacin by Mycobacterium frederiksbergense FAn9, M. gilvum ATCC 43909, M. gilvum BB1, Mycobacterium smegmatis mc2155, Mycobacterium sp. 7E1B1W, and Mycobacterium sp. RJGII-135. The results suggest that biotransformation may serve as a ciprofloxacin resistance mechanism for these bacteria.
KW - acetylation
KW - antibacterial agents
KW - ciprofloxacin
KW - drug resistance
KW - mycobacterial diseases
KW - nitroso compounds
KW - resistance mechanisms
KW - strains
KW - Mycobacterium frederiksbergense
KW - Mycobacterium gilvum
KW - Mycobacterium smegmatis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - mycobacterial infections
KW - nitrosation
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073155188&site=ehost-live&scope=site
UR - http://cjm.nrc.ca
UR - email: john.sutherland@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emergence of community-associated methicillin resistant Staphylococcus aureus in Hawaii, 2001-2003.
AU - Estivariz, C. F.
AU - Park, S. Y.
AU - Hageman, J. C.
AU - Dvorin, J.
AU - Melish, M. M.
AU - Arpon, R.
AU - Coon, P.
AU - Slavish, S.
AU - Kim, M.
AU - McDougal, L. K.
AU - Jensen, B.
AU - McAllister, S.
AU - Lonsway, D.
AU - Killgore, G.
AU - Effler, P. E.
AU - Jernigan, D. B.
JO - Journal of Infection
JF - Journal of Infection
Y1 - 2007///
VL - 54
IS - 4
SP - 349
EP - 357
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0163-4453
AD - Estivariz, C. F.: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, GA 30333, USA.
N1 - Accession Number: 20073089879. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health; Tropical Diseases
N2 - Objectives: We conducted a retrospective study to determine trends and characteristics of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Hawaii. Methods: We reviewed medical records of patients with MRSA infections during July 2001-June 2003 in four healthcare facilities. A case was defined as a patient with MRSA infection (colonization excluded), diagnosed in ambulatory settings or ≤48 h after hospitalization, without previous MRSA or healthcare risk factors. Pulsed-field gel electrophoresis (PFGE) and typing of resistance and toxin genes was performed in 40 MRSA isolates. Results: CA-MRSA infections increased from 28 (23% of MRSA infections) to 65 (32%) per quarter over the 2-year period (P<0.05). Pacific islanders accounted for 51% of 389 case-patients, but only 24% of the Hawaii population. In the pediatric hospital, Pacific Islanders represented 76% of 90 case-patients versus 35% of the hospital population. Hospital admission, required for 40% (154/389), was associated with prior antimicrobial treatment (P<0.01). The staphylococcal cassette chromosome mec type IV was detected in 38/40 isolates; 31 isolates carried Panton-Valentine leukocidin genes and 22 belonged to the same staphylococcal lineage. Conclusions: In Hawaii, prevention strategies for CA-MRSA infections should focus on Pacific Islanders. CA-MRSA infections in Hawaii appear to be related to strains causing disease throughout the United States.
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - risk factors
KW - Hawaii
KW - USA
KW - man
KW - methicillin-resistant Staphylococcus aureus
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Staphylococcus aureus
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Polynesia
KW - Oceania
KW - Pacific Islands
KW - bacterium
KW - MRSA
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073089879&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01634453
UR - email: cge3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications.
AU - Spector, W.
AU - Shaffer, T.
AU - Potter, D. E. B.
AU - Correa-de-Araujo, R.
AU - Limcangco, M. R.
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
Y1 - 2007///
VL - 55
IS - 3
SP - 327
EP - 333
CY - Boston; USA
PB - Blackwell Publishing
SN - 0002-8614
AD - Spector, W.: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20073154550. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - OBJECTIVES: To determine whether resident and facility characteristics and prescription medications influence the occurrence of fractures in nursing homes (NHs). DESIGN: Panel study with 1-year follow-up. SETTING: A nationally representative sample of NHs from the Medical Expenditure Panel Survey (MEPS). PARTICIPANTS: Residents aged 65 and older who were in sample NHs on January 1, 1996. MEASUREMENTS: Health status measures were collected from facility records and abstracted using a computer-assisted personal interview instrument. Fracture and drug data were updated every 4 months to provide a full year of information. Drug data were obtained from monthly medication administration records. The occurrences of fractures were obtained from medical records. Administered medications were classified using the Department of Veterans Affairs medication classification system. Facility characteristics were based on MEPS survey data collected from NH sources. RESULTS: In 1996, 6% of residents in a NH at the beginning of the year experienced a fracture during their NH stay(s). Resident risk factors included aged 85 and older, admitted from the community, exhibited agitated behaviors, and used both wheelchair and cane or walker. Use of anticonvulsants, antidepressants, opioid analgesics, iron supplements, bisphosphonates, thiazides, and laxatives were associated with fractures. A high certified nurse aide ratio was negatively associated with fractures. CONCLUSION: The findings indicate that fractures are associated with resident and facility characteristics and prescribing practices. It reaffirms the importance of medication review with special attention on opioid analgesics, antidepressants, and anticonvulsants to reduce the risk of fractures.
KW - age groups
KW - analgesics
KW - anticonvulsants
KW - antidepressants
KW - bone fractures
KW - drug therapy
KW - elderly
KW - epidemiology
KW - human diseases
KW - laxatives
KW - mineral supplements
KW - nursing homes
KW - opioids
KW - prescriptions
KW - risk factors
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - bisphosphonates
KW - chemotherapy
KW - elderly people
KW - older adults
KW - pain killers
KW - senior citizens
KW - thiazide
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073154550&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1532-5415.2007.01081.x
UR - email: William.Spector@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of nitrofuran residues in honey using LC-MS/MS.
AU - Lopez, M. I.
AU - Feldlaufer, M. F.
AU - Williams, A. D.
AU - Chu, P. S.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2007///
VL - 55
IS - 4
SP - 1103
EP - 1108
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Lopez, M. I.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20073070011. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 139-91-1, 67-45-8, 59-87-0, 67-20-9. Subject Subsets: Sugar Industry; Human Nutrition
N2 - A method was developed for the determination and confirmation of furazolidone, nitrofurazone, furaltadone, and nitrofurantoin as their side-chain residues in honey using liquid chromatography-tandem mass spectrometry (LC-MS/MS). An initial solid-phase extraction cleanup of the honey samples was followed by overnight hydrolysis and derivatization of the nitrofuran side-chain residues with 2-nitrobenzaldehyde. After pH adjustment and liquid-liquid extraction, the extracts were assayed by LC-MS/MS using electrospray ionization in the positive ion mode. The method was validated at concentrations ranging from 0.5 to 2.0 ppb with accuracies of 92-103% and coefficients of variation of ≤10%. The lowest calibration standard used (0.25 ppb) was defined as the limit of quantitation for all four nitrofuran side-chain residues. The extracts and standards were also used for confirmatory purposes. Honey from dosed beehives was assayed to study the stability of the nitrofuran residues and to demonstrate the effectiveness of the method.
KW - analytical methods
KW - antibacterial agents
KW - determination
KW - drug residues
KW - food contamination
KW - furaltadone
KW - furazolidone
KW - honey
KW - liquid chromatography
KW - mass spectrometry
KW - nitrofural
KW - nitrofurans
KW - nitrofurantoin
KW - analytical techniques
KW - food contaminants
KW - nitrofurazone
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Other Produce (QQ070)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073070011&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: mayda.lopez@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of nitrofuran residues in milk of dairy cows using liquid chromatography-tandem mass spectrometry.
AU - Chu, P. S.
AU - Lopez, M. I.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2007///
VL - 55
IS - 6
SP - 2129
EP - 2135
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Chu, P. S.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20073101907. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 139-91-1, 67-45-8, 59-87-0, 67-20-9. Subject Subsets: Dairy Science; Veterinary Science; Veterinary Science
N2 - An analytical method has been developed for the determination of total bound and extractable residues of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin in milk of dairy cows. The method involves overnight acid hydrolysis and simultaneous derivatization of the released side chains with 2-nitrobenzaldehyde. During hydrolysis, the bound metabolites are hydrolyzed to the side chains. After pH adjustment and solid-phase extraction cleanup, the derivatives are detected and quantitated using a liquid chromatography-tandem mass spectrometry system with an atmospheric pressure chemical ionization interface. Validation of the method is accomplished by fortifying control milk with a mixture of side chains at 1, 2, and 4 ng/g. Internal standards are added at the beginning of the procedure to compensate for matrix effects and recovery losses. Method accuracies range from 83 to 104% with coefficients of variation less than 13% for all four analytes. The limits of detection are ≤0.2 ng/g for the side chains. In the milk of a dosed cow, nitrofurantoin exhibits the lowest level of residues among the four nitrofurans. Seventy-two hours after dosing, side-chain residue levels in milk drop below 0.2 ng/g.
KW - analytical methods
KW - antibiotic residues
KW - drug residues
KW - furaltadone
KW - furazolidone
KW - hydrolysis
KW - liquid chromatography
KW - mass spectrometry
KW - milk
KW - nitrofural
KW - nitrofurantoin
KW - techniques
KW - analytical techniques
KW - nitrofurazone
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073101907&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: pak.chu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differentiation of Enterobacter sakazakii from closely related Enterobacter and Citrobacter species using fatty acid profiles.
AU - Whittaker, P.
AU - Keys, C. E.
AU - Brown, E. W.
AU - Fry, F. S.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2007///
VL - 55
IS - 11
SP - 4617
EP - 4623
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073150201. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - Capillary gas chromatography with flame ionization detection (GC-FID) was used to determine the cellular fatty acid (CFA) profiles of 134 Enterobacter sakazakii strains, and these were compared to the CFA profiles of other closely related Enterobacter and Citrobacter species. For GC-FID analysis, whole cell fatty acid methyl esters (FAMEs) from cells cultured on brain heart infusion (BHI) agar at 37°C for 24 h were obtained by saponification, methylation, and extraction into hexane/methyl tert-butyl ether. A database for E. sakazakii was prepared using fatty acid profiles from the 134 strains. Major fatty acids of E. sakazakii strains evaluated in this study were straight-chain 12:0, 14:0, and 16:0, unsaturated 18:1 ω7c, and 17:0 ωcyclo 7-8. Principal component analysis (PCA) based on CFA profiles for E. sakazakii strains shows separation of E. sakazakii subgroups A and B. The CFA profiles for E. sakazakii and Enterobacter cloacae show that there are several fatty acids, 14:0, 17:0 ωcyclo 7-8, 18:1 ω7c, and summed 16:1 ω6c/16:1 ω7c, that differ significantly between these two species. A PCA model based on CFA profiles for E. sakazakii strains clearly shows separation of E. sakazakii from closely related Enterobacter and Citrobacter species. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by a rapid GC-FID method can provide a sensitive procedure for the identification of this organism, and this analytical method provides a confirmatory procedure for the differentiation of E. sakazakii strains from closely related Enterobacter and Citrobacter species.
KW - analytical methods
KW - biochemistry
KW - fatty acids
KW - gas chromatography
KW - techniques
KW - Citrobacter
KW - Enterobacter
KW - Enterobacter sakazakii
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Enterobacter
KW - analytical techniques
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073150201&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nonfatal occupational injuries and illnesses - United States, 2004.
AU - Derk, S. J.
AU - Marsh, S. M.
AU - Jackson, L. L.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2007///
VL - 56
IS - 16
SP - 393
EP - 397
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Derk, S. J.: Div of Safety Research, National Institute for Occupational Safety and Health, CDC, Atlanta, Georgia, USA.
N1 - Accession Number: 20073115452. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report summarizes 2004 National Electronic Injury Surveillance System-work injury and illness surveillance data, conducted in 67 hospitals in the USA with 24-hour emergency departments (EDs). In 2004, an estimated 3.4 million non-fatal ED-treated injuries and illnesses occurred among workers of all ages with a rate of 2.5 cases per 100 full-time equivalent workers aged >15 years. Workers aged <25 years had the highest injury/illness rates. More than three-fourths of all non-fatal workplace injuries/illnesses were attributed to contact with objects or equipment (e.g., being struck by a falling tool or caught in machinery), bodily reaction or exertion (e.g., a sprain or strain) and falls. No substantial reduction was observed in the overall number and rate of ED-treated occupational injuries/illnesses during 1996-2004. Results show that to reduce occupational injuries/illnesses, interventions should continue to target workers at highest risk and reduce exposure to those workplace hazards with the greatest potential for causing severe injury or death. More emphasis should be placed on prevention-effectiveness studies and dissemination of successful interventions to reduce work-related injuries and illnesses.
KW - disease surveys
KW - falls
KW - hospitals
KW - human diseases
KW - medical services
KW - occupational hazards
KW - risk assessment
KW - trauma
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease surveillance
KW - traumas
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073115452&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Advanced pneumoconiosis among working underground coal miners - Eastern Kentucky and Southwestern Virginia, 2006.
AU - Attfield, M. D.
AU - Petsonk, E. L.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2007///
VL - 56
IS - 26
SP - 652
EP - 655
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Attfield, M. D.: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20073164298. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - This report describes the results of field surveys conducted in counties in Kentucky and Virginia on cases of pneumoconiosis among coal miners. Of the 4897 total miners, standardized questionnaires, spirometry (lung-capacity testing), and chest radiography were administered on 975 (20%). Of the 975 tested miners, 37 (4%) were identified to have advanced pneumoconiosis. The disease patterns were described using 4 case examples featuring patient work history, radiographic findings, and disease course. The patterns include: (1) slow disease progression consistent with coal workers' pneumoconiosis (CWP); (2) rapid disease development, with progressive massive fibrosis (PMF), atypical of the usual clinical progression of CWP and more consistent with silicosis despite lack of exposure to silica dust; (3) disease development pattern more consistent with CWP than silicosis, despite history of chronic exposure to silica dust; and (4) exposure patterns and an accelerated clinical course more consistent with silicosis than CWP. The 37 miners were categorized into two groups according to their occupation exposures (jobs associated with exposure to silica dust, such as coal-face workers, or not associated with exposure, such as roofbolters). 11 miners reported working only in jobs not associated with high silica dust levels. 26 miners included 25 who had jobs which are associated with exposure to higher levels of silica dust. Miners in both groups had worked underground in coal mining for similar periods (mean 31.2 years for coal-face workers; mean 29.1 years for roofbolters). Progressive massive fibrosis was identified in 64% of coal-face workers and 42% of roofbolters. One of 26 roofbolters (4%) progressed to PMF rapidly (in <10 years), compared with 2 of 11 coal-face workers (18%). The mean number of years to detection of PMF was similar between the two groups.
KW - atypical course
KW - coal workers
KW - diagnosis
KW - exposure
KW - fibrosis
KW - human diseases
KW - lungs
KW - miners
KW - occupational hazards
KW - occupational health
KW - pneumoconioses
KW - radiography
KW - silica
KW - silicosis
KW - Kentucky
KW - USA
KW - Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - South Atlantic States of USA
KW - pneumoconiosis
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073164298&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of results from occupational tuberculin skin tests - Mississippi, 2006.
AU - Page, E. H.
AU - Driscoll, R. J.
AU - Gibbins, J. D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2007///
VL - 56
IS - 50
SP - 1316
EP - 1318
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Page, E. H.: Div of Surveillance, Hazard Evaluations, and Field Studies National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20083045132. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - In October 2006, the National Institute for Occupational Safety and Health (NIOSH) received a request for a health hazard evaluation from a fire department in Mississippi, USA. In June 2006, the fire department had administered two-step tuberculin skin tests (TSTs) and determined that 9 firefighters tested positive for tuberculosis (TB) infection. Local investigation had identified no source of TB infection. The NIOSH evaluation was conducted to: (1) determine whether TB transmission was occurring among department firefighters; (2) assess the accuracy of positive TST results; and (3) make recommendations regarding administration of future fire department TB-testing programmes. This report describes the results of that evaluation, which indicated that all 9 firefighters had false-positive TST findings, likely caused by errors in interpretation of the test results. These results highlight the importance of conducting TB testing only when indicated by TB risk assessment and following CDC guidelines to avoid errors in TST administration and interpretation that might result in unnecessary medical evaluation and follow-up.
KW - diagnosis
KW - human diseases
KW - screening
KW - tuberculosis
KW - Mississippi
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Delta States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - bacterium
KW - screening tests
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083045132&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.
AU - Lopez, V. A.
AU - Detera-Wadleigh, S.
AU - Cardona, I.
AU - Kassem, L.
AU - McMahon, F. J.
JO - Biological Psychiatry
JF - Biological Psychiatry
Y1 - 2007///
VL - 61
IS - 2
SP - 181
EP - 186
CY - New York; USA
PB - Elsevier
SN - 0006-3223
AD - Lopez, V. A.: Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, National Institute of Mental Health, US Department of Health and Human Services, 35 Convent Drive, Room 1A-202, Bethesda, Maryland, USA.
N1 - Accession Number: 20083105812. Publication Type: Journal Article. Corporate Author: USA, The National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium Language: English. Number of References: 47 ref. Registry Number: 50-67-9, 73-22-3. Subject Subsets: Public Health
N2 - Background: Bipolar affective disorder (BPAD) is a common mental illness that is strongly associated with suicide. Suicidal behaviour is thought to result from an interaction of genetic, neurobiological, and psychosocial factors and tends to cluster in families, suggesting specific familial factors distinct from those that underlie BPAD itself. Serotonin signaling has long been implicated in both BPAD and suicide, and the gene encoding the brain-expressed isoform of tryptophan hydroxylase (TPH2) has been described. Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent. No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample. Methods: The sample consisted of 2018 members of 670 families, ascertained through a sibling pair affected with bipolar I, bipolar II, or schizoaffective-bipolar disorder and diagnosed under DSM-III/IV criteria. Three single nucleotide polymorphisms representing the common haplotypes spanning TPH2 were analysed. Results: Single-marker analysis failed to detect significant genetic association with BPAD or SA, but the number of informative families was small. Haplotype analysis showed significant association with both BPAD and SA, and the same haplotype was significantly associated with both BPAD and SA in a replication sample. Case-only analysis, stratified by SA, suggested that TPH2 was not an independent genetic risk factor for SA in this sample. Conclusions: The TPH2 might contribute to the risk of both BPAD and SA in families with BPAD. Further studies are needed to uncover the functional genetic variation that accounts for the observed associations.
KW - attitudes
KW - depression
KW - families
KW - genes
KW - genetic variation
KW - human diseases
KW - markers
KW - mental disorders
KW - risk
KW - risk factors
KW - serotonin
KW - suicide
KW - tryptophan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 5-HT
KW - 5-hydroxytryptamine
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - mental illness
KW - psychiatric disorders
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083105812&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T4S-4K8SC49-2-1&_cdi=4982&_user=6686535&_orig=browse&_coverDate=01%2F15%2F2007&_sk=999389997&view=c&wchp=dGLbVzz-zSkWb&md5=35e007c83cfd921ce654b7b080a1c2f3&ie=/sdarticle.pdf
UR - email: victorlopez1@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Follow-up study of chrysotile textile workers: cohort mortality and exposure-response.
AU - Hein, M. J.
AU - Stayner, L. T.
AU - Lehman, E.
AU - Dement, J. M.
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
Y1 - 2007///
VL - 64
IS - 9
SP - 616
EP - 625
CY - London; UK
PB - BMJ Publishing Group
SN - 1351-0711
AD - Hein, M. J.: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-13, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083256776. Publication Type: Journal Article. Language: English. Registry Number: 1332-21-4, 12001-29-5. Subject Subsets: Public Health
N2 - Objectives: This report provides an update of the mortality experience of a cohort of South Carolina asbestos textile workers. Methods: A cohort of 3072 workers exposed to chrysotile in a South Carolina asbestos textile plant (1916-77) was followed up for mortality through 2001. Standardised mortality ratios (SMRs) were computed using US and South Carolina mortality rates. A job exposure matrix provided calendar time dependent estimates of chrysotile exposure concentrations. Poisson regression models were fitted for lung cancer and asbestosis. Covariates considered included sex, race, age, calendar time, birth cohort and time since first exposure. Cumulative exposure lags of 5 and 10 years were considered by disregarding exposure in the most recent 5 and 10 years, respectively. Results: A majority of the cohort was deceased (64%) and 702 of the 1961 deaths occurred since the previous update. Mortality was elevated based on US referent rates for a priori causes of interest including all causes combined (SMR 1.33, 95% CI 1.28 to 1.39); all cancers (SMR 1.27, 95% CI 1.16 to 1.39); oesophageal cancer (SMR 1.87, 95% CI 1.09 to 2.99); lung cancer (SMR 1.95, 95% CI 1.68 to 2.24); ischaemic heart disease (SMR 1.20, 95% CI 1.10 to 1.32); and pneumoconiosis and other respiratory diseases (SMR 4.81, 95% CI 3.84 to 5.94). Mortality remained elevated for these causes when South Carolina referent rates were used. Three cases of mesothelioma were observed among cohort members. Exposure-response modelling for lung cancer, using a linear relative risk model, produced a slope coefficient of 0.0198 (fibre-years/ml) (standard error 0.00496), when cumulative exposure was lagged 10 years. Poisson regression modelling confirmed significant positive relations between estimated chrysotile exposure and lung cancer and asbestosis mortality observed in previous updates of this cohort. Conclusions: This study confirms the findings from previous investigations of excess mortality from lung cancer and asbestosis and a strong exposure-response relation between estimated exposure to chrysotile and mortality from lung cancer and asbestosis.
KW - asbestos
KW - asbestosis
KW - chrysotile
KW - exposure
KW - human diseases
KW - lung cancer
KW - mortality
KW - neoplasms
KW - oesophageal cancer
KW - respiratory diseases
KW - textile workers
KW - South Carolina
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - cancers
KW - death rate
KW - esophageal cancer
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083256776&site=ehost-live&scope=site
UR - http://oem.bmj.com/cgi/content/abstract/64/9/616
UR - email: MHein@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Supplemental calcium and risk reduction of hypertension, pregnancy-induced hypertension, and preeclampsia: an evidence-based review by the US Food and Drug Administration.
AU - Trumbo, P. R.
AU - Ellwood, K. C.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2007///
VL - 65
IS - 2
SP - 78
EP - 87
CY - Washington; USA
PB - International Life Sciences Institute (ILSI Press)
SN - 0029-6643
AD - Trumbo, P. R.: Division of Nutrition Programs and Labeling, US Food and Drug Administration, HFS-830, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073066188. Publication Type: Journal Article. Language: English. Number of References: 92 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition; Public Health
N2 - The labelling of health claims that meet the significant scientific agreement standard (authorized health claims) and qualified health claims on conventional foods and dietary supplements requires premarket approval by the US Food and Drug Administration (FDA). FDA conducts an evidence-based review to determine whether there is sufficient evidence to support an authorized or qualified health claim. An evidence-based review was conducted on the human intervention and observational studies evaluating the role of supplemental calcium in reducing the risk of hypertension, pregnancy-induced hypertension, and preeclampsia. This review provides FDA's evaluation of the current scientific evidence on the role of supplemental calcium in reducing the risk of these three end points. Based on this evidence-based review, the agency concluded that the relationship between calcium and risk of hypertension is inconsistent and inconclusive, and the relationship between calcium and risk of pregnancy-induced hypertension and preeclampsia is highly unlikely.
KW - calcium
KW - human diseases
KW - hypertension
KW - preeclampsia
KW - pregnancy
KW - reviews
KW - risk reduction
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - high blood pressure
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073066188&site=ehost-live&scope=site
UR - email: Paula.Trumbo@FDA.HHS.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The US FDA and animal cloning: risk and regulatory approach.
AU - Rudenko, L.
AU - Matheson, J. C.
A2 - Thompson, J.
A2 - Vajta, G.
A2 - Kochhar, H.
A2 - Thibier, M.
A2 - Imai, H.
JO - Theriogenology
JF - Theriogenology
Y1 - 2007///
VL - 67
IS - 1
SP - 198
EP - 206
CY - New York; USA
PB - Elsevier
SN - 0093-691X
AD - Rudenko, L.: Center for Veterinary Medicine, US Food and Drug Administration, Department of Health and Human Services, 7500 Standish Place, HFV-100, Rockville, MD 20855, USA.
N1 - Accession Number: 20073033371. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 81 ref. Subject Subsets: Agricultural Biotechnology; Pig Science; Animal Breeding; Leisure, Recreation, Tourism
N2 - The Food and Drug Administration's (FDA's) Center for Veterinary Medicine issued a voluntary request to producers of livestock clones not to introduce food from clones or their progeny into commerce until the agency had assessed whether production of cattle, swine, sheep, or goats by somatic cell nuclear transfer (SCNT) posed any unique risks to the animal(s) involved in the process, humans, or other animals by consuming food from those animals, compared with any other assisted reproductive technology (ART) currently in use. Following a comprehensive review, no anomalies were observed in animals produced by cloning that have not also been observed in animals produced by other ARTs and natural mating. Further systematic review on the health of, and composition of meat and milk from, cattle, swine, and goat clones and the progeny of cattle and sheep did not result in the identification of any food-consumption hazards. The agency therefore concluded that food from cattle, swine, and goat clones was as safe to eat as food from animals of those species derived by conventional means. The agency also concluded that food from the progeny of the clone of any species normally consumed for food is as safe to eat as those animals. The article also describes the methodology used by the agency to analyze data and draw these conclusions, the plans the agency has proposed to manage any identified risks, and the risk communication approaches the agency has used.
KW - animal cloning
KW - animal products
KW - food safety
KW - genetically engineered organisms
KW - methodology
KW - progeny
KW - public agencies
KW - risk
KW - risk assessment
KW - transgenic animals
KW - USA
KW - cattle
KW - goats
KW - pigs
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Capra
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - government agencies
KW - hogs
KW - methods
KW - nuclear transfer
KW - risk communication
KW - swine
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Cell, Tissue and Embryo Manipulation (WW300) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073033371&site=ehost-live&scope=site
UR - http://www.sciencedirect.co./science/journal/0093691x
UR - email: larisa.rudenko@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Use of a real time PCR assay for detection of the ctxA gene of Vibrio cholerae in an environmental survey of Mobile Bay.
AU - Blackstone, G. M.
AU - Nordstrom, J. L.
AU - Bowen, M. D.
AU - Meyer, R. F.
AU - Imbro, P.
AU - Depaola, A.
T2 - Journal of Microbiological Methods
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2007///
VL - 68
IS - 2
SP - 254
EP - 259
CY - Oxford; UK
PB - Elsevier
SN - 0167-7012
AD - Blackstone, G. M.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20073121068. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Tropical Diseases; Soils & Fertilizers
N2 - Toxigenic Vibrio cholerae, the etiological agent of cholera, is a natural inhabitant of the marine environment and causes severe diarrheal disease affecting thousands of people each year in developing countries. It is the subject of extensive testing of shrimp produced and exported from these countries. We report the development of a real time PCR (qPCR) assay to detect the gene encoding cholera toxin, ctxA, found in toxigenic V. cholerae strains. This assay was tested against DNA isolated from soil samples collected from diverse locations in the US, a panel of eukaryotic DNA from various sources, and prokaryotic DNA from closely related and unrelated bacterial sources. Only Vibrio strains known to contain ctxA generated a fluorescent signal with the 5′ nuclease probe targeting the ctxA gene, thus confirming the specificity of the assay. In addition, the assay was quantitative in pure culture across a six-log dynamic range down to <10 CFU per reaction. To test the robustness of this assay, oysters, aquatic sediments, and seawaters from Mobile Bay, AL, were analyzed by qPCR and traditional culture methods. The assay was applied to overnight alkaline peptone water enrichments of these matrices after boiling the enrichments for 10 min. Toxigenic V. cholerae strains were not detected by either qPCR or conventional methods in the 16 environmental samples examined. A novel exogenous internal amplification control developed by us to prevent false negatives identified the samples that were inhibitory to the PCR. This assay, with the incorporated internal control, provides a highly specific, sensitive, and rapid detection method for the detection of toxigenic strains of V. cholerae.
KW - detection
KW - food contamination
KW - genes
KW - marine sediments
KW - microbial contamination
KW - oysters
KW - polymerase chain reaction
KW - sea water
KW - strains
KW - water pollution
KW - Alabama
KW - USA
KW - Vibrio cholerae
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - America
KW - APEC countries
KW - Developed Countries
KW - East South Central States of USA
KW - Gulf States of USA
KW - North America
KW - OECD Countries
KW - Southeastern States of USA
KW - Southern States of USA
KW - USA
KW - bacterium
KW - food contaminants
KW - PCR
KW - seawater
KW - United States of America
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073121068&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T30-4M33VT0-1&_user=10&_coverDate=02%2F28%2F2007&_rdoc=9&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%234932%232007%23999319997%23643061%23FLA%23display%23Volume)&_cdi=4932&_sort=d&_docanchor=&view=c&_ct=39&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=539b2b5f08687dc1dc7b6dc93569e88a
UR - email: George.Blackstone@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular confirmation of oysters as the vector for hepatitis A in a 2005 multistate outbreak.
AU - Shieh, Y. C.
AU - Khudyakov, Y. E.
AU - Xia, G.
AU - Ganova-Raeva, L. M.
AU - Khambaty, F. M.
AU - Woods, J. W.
AU - Veazey, J. E.
AU - Motes, M. L.
AU - Glatzer, M. B.
AU - Bialek, S. R.
AU - Fiore, A. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 1
SP - 145
EP - 150
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Shieh, Y. C.: U.S. Food and Drug Administration Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20073046953. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Numerous hepatitis A outbreaks were linked to the consumption of raw molluscan shellfish in the United States between 1960 and 1989. However, there had been no major molluscan shellfish-associated hepatitis A outbreaks reported in the United States for more than a decade (1989 to 2004). Beginning in late August 2005, at least 10 clusters of hepatitis A illnesses, totaling 39 persons, occurred in four states among restaurant patrons who ate oysters. Epidemiologic data indicated that oysters were the source of the outbreak. Traceback information showed that the implicated oysters were harvested from specific Gulf Coast areas. A voluntary recall of oysters was initiated in September. Hepatitis A virus (HAV) was detected in multiple 25-g portions in one of two recalled samples, indicating that as many as 1 of every 15 oysters from this source was contaminated. Comparing 315 nucleotides within the HAV VP1-2B region, 100% homology was found among four amplicons recovered from a total of six independent experiments of the implicated oysters, and an identical HAV sequence was detected in sera from all 28 patient serum specimens tested. Ten percent heterogeneity over 315 nucleotides (31 variants) was observed between the outbreak strain (subgenotype 1A) and an HM-175 strain (subgenotype 1B) used in the laboratory where the oysters were processed. To our knowledge, this investigation is the first in the United States to identify an HAV-identical strain in persons with hepatitis A as well as in the food that was implicated as the source of their infections.
KW - epidemiology
KW - food contamination
KW - food hygiene
KW - food safety
KW - hepatitis A
KW - human diseases
KW - microbial contamination
KW - outbreaks
KW - oysters
KW - USA
KW - Hepatitis A virus
KW - man
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073046953&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: carol.shieh@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of two enzyme-linked immunosorbent assay tests marketed for detection of ruminant proteins in finished feed.
AU - Myers, M. J.
AU - Yancy, H. F.
AU - Farrell, D. E.
AU - Washington, J. D.
AU - Deaver, C. M.
AU - Frobish, R. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 3
SP - 692
EP - 699
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Myers, M. J.: Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20073084314. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Human Nutrition; Animal Nutrition; Dairy Science
N2 - The performance characteristics of two enzyme-linked immunosorbent assay (ELISA) test kits, ELISA Technologies' MELISA-Tek test and Tepnel BioSystems' BioKit for (Cooked) Species Identification test, designed to detect ruminant proteins in animal feed, were evaluated. The test kits were evaluated by using acceptance criteria developed by the U.S. Food and Drug Administration's Center for Veterinary Medicine Office of Research for evaluating selectivity, sensitivity, ruggedness, and specificity. The acceptance criteria for determining success used a statistical approach requiring a 90% probability of achieving the correct response within a 95% confidence interval. In practice, this measure requires the test to achieve the correct response 58 times for every 60 samples evaluated, or a 96.7% accuracy rate. A minimum detection level of 0.1% bovine meat and bone meal (BMBM) was required, consistent with the sensitivity of the analytical methods presently used by the U.S. Food and Drug Administration. Selectivity was assessed by testing 60 dairy feed samples that contained no added animal proteins; sensitivity was determined by evaluating 60 samples (per level of fortification) of this same feed that contained 0.025, 0.05, 0.1, 0.25, 0.5, 1, or 2% BMBM. The MELISA-Tek test passed the acceptance set-point criteria for selectivity assessment but failed the sensitivity assessment at all levels except at the 2% level. The MELISA-Tek test came close to passing at the 1% level, detecting true-positive findings at a rate of 93%, but failed at lower levels, in spite of the label claim of 0.5% sensitivity. The BioKit for (Cooked) Species Identification test detected only 2 of 17 samples fortified at the 2% BMBM level and failed to detect any other BMBM-fortified samples. The results of this evaluation indicate that neither test is adequate for regulatory use.
KW - bone meal
KW - detection
KW - ELISA
KW - feed additives
KW - feed formulation
KW - meat meal
KW - milk products
KW - proteins
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - dairy products
KW - enzyme linked immunosorbent assay
KW - Feed Composition and Quality (RR300)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073084314&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: michael.myers@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of sesame seed DNA in foods using real-time PCR.
AU - Brzezinski, J. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 4
SP - 1033
EP - 1036
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Brzezinski, J. L.: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237-3097, USA.
N1 - Accession Number: 20073102039. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9007-49-2. Subject Subsets: Weeds; Human Nutrition; Wheat, Barley & Triticale Abstracts; Postharvest Research
N2 - The detection of potentially allergenic foods, such as sesame seeds, in food products is a major concern for the food-processing industry. A real-time PCR method was designed to determine if sesame seed DNA is present in food products. The PCR reaction amplifies a 66-bp fragment of the sesame seed 2S albumin gene, which is detected with a sesame-specific, dual-labeled TaqMan probe. This reaction will not amplify DNA derived from other seeds present in baked goods, such as pumpkin, poppy, and sunflower seeds. Additionally, this assay will not cross-react with DNA from several tree nut species, such as almond, Brazil nut, cashew, hazelnut, and walnut, as well as four varieties of peanut. This assay is sensitive enough to detect 5 pg of purified sesame seed DNA, as well as sesame seed DNA in a spiked wheat cracker sample.
KW - allergens
KW - assays
KW - crackers
KW - detection
KW - DNA
KW - food allergies
KW - food contamination
KW - polymerase chain reaction
KW - sesame
KW - sesame seed
KW - wheat
KW - wild relatives
KW - Sesamum indicum
KW - Triticum
KW - Sesamum
KW - Pedaliaceae
KW - Scrophulariales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - beniseed
KW - deoxyribonucleic acid
KW - food contaminants
KW - food hypersensitivity
KW - PCR
KW - Weeds and Noxious Plants (FF500)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073102039&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: jennifer.brzezinski@fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of a novel hydrophilic infrared-transparent membrane to the differentiation between microcolonies of Enterobacter sakazakii and Klebsiella pneumoniae.
AU - Mossoba, M. M.
AU - Al-Khaldi, S. F.
AU - Curtis, S. K.
AU - Battrell, C. F.
AU - Fry, F. S.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 5
SP - 1241
EP - 1245
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Mossoba, M. M.: Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073128413. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9002-88-4. Subject Subsets: Human Nutrition; Dairy Science
N2 - A proof-of-concept study is reported for the differentiation between microcolonies of Enterobacter sakazakii and Klebsiella pneumoniae by means of a novel sample preparation for infrared (IR) analysis. A disposable, IR-transparent, microporous (0.2-µm pores), hydrophobic, polyethylene (PE) membrane (51 µm thick) was plasma treated under an oxygen atmosphere and used to (i) filter (or print microarrays of) dilute aqueous foodborne bacterial suspensions and (ii) subsequently grow bacterial microcolonies when the treated, hydrophilic PE membrane was placed over brain heart infusion agar medium and incubated. Because this unique membrane is transparent to IR light, isolated microcolonies (200 µm) of bacterial cells grown on this PE substrate for the first time could be directly fingerprinted by IR microspectroscopy in the transmission mode. Hence, time-consuming bacterial cell transfer from culture plates to an IR sample holder for subsequent measurement by IR spectroscopy was eliminated. Multivariate analysis of the observed IR spectra for microcolonies allowed the rapid differentiation between E. sakazakii and K. pneumoniae.
KW - food contamination
KW - infant formulae
KW - infrared radiation
KW - infrared spectroscopy
KW - membranes
KW - microbial contamination
KW - polyethylene
KW - Enterobacter sakazakii
KW - Klebsiella pneumoniae
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Klebsiella
KW - bacterium
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - polythene
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073128413&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial susceptibility of Salmonella isolated from various products, from 1999 to 2003.
AU - Kiessling, C. R.
AU - Jackson, M.
AU - Watts, K. A.
AU - Loftis, M. H.
AU - Kiessling, W. M.
AU - Buen, M. B.
AU - Laster, E. W.
AU - Sofos, J. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 6
SP - 1334
EP - 1338
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Kiessling, C. R.: Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20073150101. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 85721-33-1, 57-92-1, 60-54-8, 64-75-5. Subject Subsets: Human Nutrition
N2 - Foodborne salmonellosis continues to be a major health concern worldwide; thus, detection and tracking of antimicrobial resistance in Salmonella isolates is of interest. The U.S. Food and Drug Administration initiated antimicrobial sensitivity screening of Salmonella isolates from food and related samples in 1999. This paper summarizes the antimicrobial resistance data for Salmonella isolates obtained from 1999 to 2003. A total of 22,231 imported and domestic samples were analyzed for Salmonella, of which 1,319 (5.9%) yielded the pathogen. Since more than one culture was isolated from some samples, the total number of isolates obtained and tested for antimicrobial sensitivity was 1,382. Antimicrobial sensitivity screening was performed with the disc diffusion assay on 11 antimicrobial agents. Of the 1,108 food isolates screened, 42.1% (n=467) were serotypes Weltevreden, Newport, Lexington, Senftenberg, Typhimurium, Saint Paul, Paratyphi, Enteritidis, Thompson, and Bareilly. A total of 249 (18.0%) isolates from all sources were resistant to two or more antimicrobials. Resistance to sulfisoxazole, streptomycin, and tetracycline was most common, whereas resistance to ciprofloxacin was least common. Weltevreden (n=148) was the most common serotype isolated from food, but only nine (6.1%) of these isolates were resistant to two or more antimicrobials. In contrast, although Derby was recovered only 19 times, 11 (57.9%) of these isolates were resistant to two or more antimicrobials. Of the 274 isolates from animal feed, dog treats and environmental swabs, 49.6% (n=136) belonged to serotypes Infantis, Mbandaka, Anatum, Senftenberg, Typhimurium, Montevideo, Cerro, Enteritidis, and Bredeney, with 76 (27.7%) of these isolates resistant to two or more antimicrobials. Only limited trends in antimicrobial resistance were observed over time, with resistance to sulfisoxazole increasing, resistance to tetracycline decreasing, and resistance to streptomycin fluctuating.
KW - antibacterial agents
KW - ciprofloxacin
KW - drug resistance
KW - drug susceptibility
KW - food contamination
KW - microbial contamination
KW - strains
KW - streptomycin
KW - tetracycline
KW - Salmonella
KW - Salmonella anatum
KW - Salmonella enteritidis
KW - Salmonella paratyphi
KW - Salmonella typhimurium
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - achromycin
KW - bacterium
KW - food contaminants
KW - Salmonella bareilly
KW - Salmonella bredeney
KW - Salmonella cerro
KW - Salmonella derby
KW - Salmonella infantis
KW - Salmonella lexington
KW - Salmonella mbandaka
KW - Salmonella montevideo
KW - Salmonella newport
KW - Salmonella saint
KW - Salmonella saint paul
KW - Salmonella senftenberg
KW - Salmonella thompson
KW - Salmonella weltevreden
KW - sulfisoxazole
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073150101&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: connie.kiessling@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Salmonella and Campylobacter in United Kingdom retail raw chicken in 2005.
AU - Meldrum, R. J.
AU - Wilson, I. G.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 8
SP - 1937
EP - 1939
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, UK.
N1 - Accession Number: 20073218812. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition; Poultry; Public Health
N2 - The United Kingdom Food Standards Agency commissioned a survey of Salmonella and Campylobacter in raw, whole chickens at retail in Wales and Northern Ireland between March and December 2005 to measure the baseline prevalence rates of these two significant pathogens. In total, 877 retail samples were examined for Campylobacter and Salmonella by enrichment methods. Overall contamination rates of 70.2% for Campylobacter and 4.0% for Salmonella were found. There was a statistically significant difference in Campylobacter rates between fresh and frozen samples, with fresh samples having a higher rate. There was no statistically significant difference between samples taken from retailers and butchers. Campylobacter was significantly more common in Northern Ireland than in Wales. Salmonella was significantly more common in Wales. The findings indicate the need for further investigation to explore why measures that have been successful in reducing Salmonella in the United Kingdom in recent years have failed to contribute to the control of Campylobacter. Identifying the factors responsible could lead to the introduction of more effective controls throughout the industry.
KW - chicken meat
KW - food contamination
KW - human diseases
KW - poultry
KW - salmonellosis
KW - Northern Ireland
KW - UK
KW - Wales
KW - Campylobacter
KW - fowls
KW - man
KW - Salmonella
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - bacterium
KW - Britain
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - Salmonella infections
KW - United Kingdom
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073218812&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occurrence of Listeria monocytogenes in sandwiches available to hospital patients in Wales, United Kingdom.
AU - Meldrum, R. J.
AU - Smith, R. M. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 8
SP - 1958
EP - 1960
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20073218816. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - A survey for the presence of Listeria monocytogenes in hospital sandwiches was carried out in Wales, United Kingdom, between October 2005 and March 2006. The main aim of the survey was to establish the baseline rate of L. monocytogenes in hospital sandwiches after an outbreak of listeriosis among hospital patients in 2004 was epidemiologically linked to the consumption of contaminated sandwiches. The overall positive rate found in hospital sandwiches was 2.84% for enriched culture and 0.21% for direct counts. The unsatisfactory rate (>100 CFU/g) for hospital sandwiches was 0.1%. The conclusion was that hospital sandwiches generally presented a low hazard to consumers. In addition to establishing the overall baseline and the unsatisfactory rates in hospital sandwiches in Wales for this period, the study compared the rates found in hospital sandwiches with the rates found in sandwiches simultaneously sampled from general retailers. The aim of this part of the study was to compare the relative rates associated with hospital and retail sandwiches to ascertain if there were any differences in the positive rate. The conclusion of this part of the survey was that there was not a statistically significant difference in rates between sandwiches sampled from hospitals and those sampled from general retailers.
KW - epidemiology
KW - hospital catering
KW - hospitals
KW - human diseases
KW - listeriosis
KW - outbreaks
KW - sandwiches
KW - UK
KW - Wales
KW - Listeria monocytogenes
KW - man
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - hospital food service
KW - listerellosis
KW - United Kingdom
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Service (QQ700) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073218816&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of an in vitro bioassay for the detection of purified ricin and castor bean in beverages and liquid food matrices.
AU - Brzezinski, J. L.
AU - Craft, D. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007///
VL - 70
IS - 10
SP - 2377
EP - 2382
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Brzezinski, J. L.: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20073285534. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9009-86-3. Subject Subsets: Human Nutrition
N2 - The potential use of ricin as a biological weapon in food highlights the necessity for the development of food-specific detection methods. Current methods for the detection of ricin consist of various immunoassays, which detect only one subunit of the ricin toxin and therefore may not be indicative of a biologically active molecule. An in vivo assay, such as a mouse bioassay, can indicate the biological activity of the toxin; however, this method is not feasible for laboratories that do not have animal testing facilities. The purpose of this study was to develop an in vitro assay for the detection of biologically active ricin in beverages and liquid foods. Acidic and high-protein beverages were spiked with either purified ricin or ground castor beans and added to cultured human Jurkat cells. After an overnight incubation, the supernatant was tested for lactate dehydrogenase (LDH) activity with a colorimetric assay. LDH was released from the cytosol upon cell damage and was positively correlated with cell death. Ricin was detectable in all the matrices tested, with a sensitivity of 10 to 100 pg/ml. Biologically active ricin was detectable in all the matrices incubated with ground castor bean material. This method provides a confirmatory way to detect biologically active ricin that can be utilized by laboratories lacking animal facilities.
KW - beverages
KW - bioassays
KW - bioterrorism
KW - food contamination
KW - methodology
KW - microbial contamination
KW - ricin
KW - terrorism
KW - toxins
KW - drinks
KW - food contaminants
KW - methods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Conflict (UU495) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073285534&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: jennifer.brzezinski@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative in vitro toxicity of grape- and citrus-farm dusts.
AU - Vallyathan, V.
AU - Pack, D.
AU - Leonard, S.
AU - Lawson, R.
AU - Schenker, M.
AU - Castranova, V.
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2007///
VL - 70
IS - 1/2
SP - 95
EP - 106
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Vallyathan, V.: Pathology and Physiology Branch, Health Effects Laboratory Division, 1095 Willowdale Road, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073030831. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 7722-84-1, 9001-60-9.
N2 - Agricultural workers are exposed to a variety of airborne dusts, including crystalline silica and other inorganic minerals. This study was designed to characterize the organic and inorganic components of agricultural dusts in California grape- and citrus-farm fields and to compare their cytotoxicity using in vitro toxicity bioassays as predictors of pathogenicity. Aerosolized dusts collected from farm fields were characterized by scanning electron microscopic energy-dispersive x-ray analysis, x-ray diffraction, trace metal analysis by plasma emission spectroscopy and surface area measurements. As indicators of cytotoxicity, cell viability, release of alveolar enzymes activities (lactate dehydrogenase and N-acetyl glucosaminidase), production of reactive oxygen species (ROS), such as H2O2 and hydroxyl radical and lipid peroxidation were monitored after exposure of cells to grape- and citrus-farm dusts or inorganic components of these dusts. In addition, activation of nuclear factor κ B and activator protein-1 were evaluated at the peak time for response of 36 h post-exposure. All toxicity studies were done in comparison to crystalline silica of similar particle size and diameter using the same mass concentrations as farm dusts. The results showed that inorganic minerals in the aerosolized farm dust fractions were mostly composed of aluminium silicates, crystalline silica and free iron. Crystalline silica used in these studies was more cytotoxic than grape- and citrus-farm dusts. However, in general, citrus farm dust exhibited the greatest ability to generate ROS and induce lipid peroxidation. These results support human epidemiologic studies, reporting an increased incidence of pulmonary fibrosis in farm workers, by documenting the potential of farm dusts to induce oxidative stress and initiate disease development.
KW - cytotoxicity
KW - dusts
KW - enzyme activity
KW - enzymes
KW - exposure
KW - hydrogen peroxide
KW - in vitro
KW - lactate dehydrogenase
KW - lipid peroxidation
KW - pesticide residues
KW - silicates
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - N-acetyl glucosaminidase
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073030831&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: vav1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of C-glycoside flavonoids as potential mutagenic compounds in kava.
AU - Jhoo, J. W.
AU - Ang, C. Y. W.
AU - Heinze, T. M.
AU - Deck, J.
AU - Schnackenberg, L. K.
AU - Beger, R. D.
AU - Dragull, K.
AU - Tang, C. S.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2007///
VL - 72
IS - 2
SP - C120
EP - C125
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0022-1147
AD - Jhoo, J. W.: Natl. Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20073077351. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Kava (Piper methysticum) extract products have been implicated in a number of severe hepatotoxicity cases. However, systematic toxicological studies regarding kava consumption have not been reported. In this study, 6 major kavalactones and different solvent fractions of kava roots, leaves, and stem peelings were evaluated for their mutagenic potential. None of the kavalactones was found to be positive in the experimental concentration ranges tested by the umu test (a sensitive test for point mutations). However, among the different solvent fractions, the n-butanol fraction of kava leaves was positive. Further investigations using bioassay-directed isolation and analysis indicated that 2 C-glycoside flavonoid compounds accounted for the positive mutagenic results. Two isolated compounds were identified as 2″-O-rhamnosylvitexin and schaftoside by NMR and MS techniques.
KW - flavonoids
KW - glycosides
KW - lactones
KW - leaves
KW - medicinal plants
KW - mutagenicity
KW - mutagens
KW - plant extracts
KW - roots
KW - stems
KW - Piper methysticum
KW - Piper
KW - Piperaceae
KW - Piperales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - 2"-O-rhamnosylvitexin
KW - drug plants
KW - heterosides
KW - medicinal herbs
KW - officinal plants
KW - schaftoside
KW - Non-food/Non-feed Plant Products (SS200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073077351&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/JFDS
UR - email: jjhoo@kangwon.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anti-asthmatic effects of perilla seed oil in the guinea pig in vitro and in vivo.
AU - Deng YangMei
AU - Xie QiangMin
AU - Zhang ShuiJuan
AU - Yao HongYi
AU - Zhang Hui
JO - Planta Medica
JF - Planta Medica
Y1 - 2007///
VL - 73
IS - 1
SP - 53
EP - 58
CY - Stuttgart; Germany
PB - Georg Thieme Verlag
SN - 0032-0943
AD - Deng YangMei: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration, Medical Science College of Zhejiang University, Yu Hang Tang Road No.388, Hangzhou 310058, China.
N1 - Accession Number: 20073049102. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - The aim of this study was to investigate the anti-asthmatic effects of Perilla seed oil in vitro and in vivo in sensitized guinea pigs. Aerosolized antigen caused an immediate bronchoconstriction. Perilla seed oil per os inhibited the increase in lung resistance and the decrease in dynamic lung compliance in a dose-dependent manner with an ED50 (95% confidence interval, CI) of 1.10 (0.98-1.24) g/kg and 1.07 (0.94-1.22) g/kg, respectively. Infiltration of leukocytes, mononuclear cells, eosinophils and neutrophils induced by inhaling antigen was also inhibited by Perilla seed oil in a dose-dependent manner with an ED50 (95% CI) of 1.00 (0.86-1.15), 1.24 (1.10-1.38), 0.63 (0.51-0.77) and 0.61 (0.38-0.98) g/kg, respectively. Perilla seed oil (5-500 µg/mL) inhibited the slow reaction substance of anaphylaxis (SRS-A) release induced by antigen challenge in lung tissue of sensitized guinea pigs. It also inhibited calcium ionophore (A23187)-induced leukotriene (LT) D4 release from the lung tissue of non-sensitized guinea pigs in a concentration-dependent manner with an IC50 (95% CI) of 50 (36-69) µg/mL. These results indicate that Perilla seed oil may improve lung function in asthma by controlling eicosanoid production and suppressing LT generation.
KW - anaphylaxis
KW - asthma
KW - eosinophils
KW - in vitro
KW - leukocytes
KW - leukotrienes
KW - medicinal plants
KW - neutrophils
KW - seed oils
KW - traditional medicines
KW - guineapigs
KW - Perilla frutescens
KW - Cavia
KW - Caviidae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Perilla
KW - Lamiaceae
KW - Lamiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - anaphylactic reactions
KW - anaphylactic shock
KW - drug plants
KW - eosinophil leukocytes
KW - guinea pigs
KW - leucocytes
KW - medicinal herbs
KW - officinal plants
KW - white blood cells
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073049102&site=ehost-live&scope=site
UR - http://www.thieme-connect.com/ejournals/toc/plantamedica
UR - email: xieqm@zju.edu.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - PCR-based detection of Angiostrongylus cantonensis in tissue and mucus secretions from molluscan hosts.
AU - Qvarnstrom, Y.
AU - Sullivan, J. J.
AU - Bishop, H. S.
AU - Hollingsworth, R.
AU - Silva, A. J. da
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2007///
VL - 73
IS - 5
SP - 1415
EP - 1419
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Qvarnstrom, Y.: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4700 Buford Highway NE, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20073069411. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health; Helminthology
N2 - Angiostrongylus cantonensis is a common cause of human eosinophilic meningitis. Recent outbreaks of this infection have shown that there is a need to determine the distribution of this nematode in the environment in order to control transmission. A. cantonensis is generally identified morphologically in the molluscan intermediate host by microscopic examination, which can be labor-intensive. The aim of this study was to develop a PCR-based method to detect A. cantonensis directly from molluscan tissue. A total of 34 Parmarion cf. martensi (Simroth) semislugs, 25 of which were naturally infected with A. cantonensis, were used to develop this assay. Tissue pieces (approximately 25 mg) were digested with pepsin-HCl to recover third-stage larvae for morphological identification or were used for DNA extraction. PCR primers were designed to amplify 1,134 bp from the Angiostrongylus 18S rRNA gene, and the amplicons produced were sequenced for identification at the species level. Both microscopy and the PCR-DNA sequencing analysis indicated that the same 25 semislugs were positive for A. cantonensis, showing that the two methods were equally sensitive and specific for this application. However, morphological detection requires access to living mollusks, whereas molecular analysis can also be performed with frozen tissue. The PCR-DNA sequencing method was further evaluated using tissue from Veronicella cubensis (Pfeiffer) slugs and mucus secretions from infected P. martensi. To our knowledge, this is the first use of a PCR-based method to confirm the presence of A. cantonensis in mollusks collected in the environment.
KW - analytical methods
KW - angiostrongyliasis
KW - detection
KW - human diseases
KW - intermediate hosts
KW - polymerase chain reaction
KW - techniques
KW - Angiostrongylus cantonensis
KW - Mollusca
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Angiostrongylus
KW - Angiostrongylidae
KW - Rhabditida
KW - Chromadoria
KW - Chromadorea
KW - Nematoda
KW - analytical techniques
KW - nematodes
KW - Parastrongylus cantonensis
KW - Parmarion martensi
KW - PCR
KW - Secernentea
KW - secondary hosts
KW - Strongylida
KW - Veronicella cubensis
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073069411&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: abs8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Development of a multiplex real-time PCR assay with an internal amplification control for the detection of total and pathogenic Vibrio parahaemolyticus bacteria in oysters.
AU - Nordstrom, J. L.
AU - Vickery, M. C. L.
AU - Blackstone, G. M.
AU - Murray, S. L.
AU - DePaola, A.
T2 - Applied and Environmental Microbiology
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2007///
VL - 73
IS - 18
SP - 5840
EP - 5847
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Nordstrom, J. L.: Gulf Coast Seafood Laboratory, Division of Seafood Science and Technology, U.S. Food and Drug Administration, P.O. Box 158, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20073241012. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition
N2 - Vibrio parahaemolyticus is an estuarine bacterium that is the leading cause of shellfish-associated cases of bacterial gastroenteritis in the United States. Our laboratory developed a real-time multiplex PCR assay for the simultaneous detection of the thermolabile hemolysin (tlh), thermostable direct hemolysin (tdh), and thermostable-related hemolysin (trh) genes of V. parahaemolyticus. The tlh gene is a species-specific marker, while the tdh and trh genes are pathogenicity markers. An internal amplification control (IAC) was incorporated to ensure PCR integrity and eliminate false-negative reporting. The assay was tested for specificity against >150 strains representing eight bacterial species. Only V. parahaemolyticus strains possessing the appropriate target genes generated a fluorescent signal, except for a late tdh signal generated by three strains of V. hollisae. The multiplex assay detected <10 CFU/reaction of pathogenic V. parahaemolyticus in the presence of >104 CFU/reaction of total V. parahaemolyticus bacteria. The real-time PCR assay was utilized with a most-probable-number format, and its results were compared to standard V. parahaemolyticus isolation methodology during an environmental survey of Alaskan oysters. The IAC was occasionally inhibited by the oyster matrix, and this usually corresponded to negative results for V. parahaemolyticus targets. V. parahaemolyticus tlh, tdh, and trh were detected in 44, 44, and 52% of the oyster samples, respectively. V. parahaemolyticus was isolated from 33% of the samples, and tdh+ and trh+ strains were isolated from 19 and 26%, respectively. These results demonstrate the utility of the real-time PCR assay in environmental surveys and its possible application to outbreak investigations for the detection of total and pathogenic V. parahaemolyticus.
KW - analytical methods
KW - assays
KW - brackishwater animals
KW - genes
KW - haemolysins
KW - marker genes
KW - oysters
KW - polymerase chain reaction
KW - USA
KW - Grimontia hollisae
KW - Vibrio parahaemolyticus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Grimontia
KW - analytical techniques
KW - bacterium
KW - estuarine animals
KW - hemolysins
KW - PCR
KW - United States of America
KW - Vibrio hollisae
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Aquatic Biology and Ecology (MM300)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073241012&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: jessica.nordstrom@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Evaluation of two DNA template preparation methods for post-immunomagnetic separation detection of Cryptosporidium parvum in foods and beverages by PCR.
AU - Frazar, C. D.
AU - Orlandi, P. A.
T2 - Applied and Environmental Microbiology
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2007///
VL - 73
IS - 22
SP - 7474
EP - 7476
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Frazar, C. D.: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA.
N1 - Accession Number: 20073284765. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 9007-49-2. Subject Subsets: Protozoology
N2 - Cryptosporidium parvum oocysts were recovered by immunomagnetic separation from 6 artificially contaminated foods. Two DNA isolation methods were subsequently evaluated by polymerase chain reaction (PCR). The FTA Concentrator-PS filter provided rapid and reproducible detection, although variability increased at lower inoculum levels (88 and 15% detection in high- and low-inoculum-level samples, respectively). Total DNA extraction generated consistent results at all oocyst levels, but resulted in longer analysis time (100 and 59% detection in high- and low-inoculum-level samples, respectively). Also reflected in this study was that the matrix played an important role in the ability to recover oocysts, as sample turbidity, pH and PCR inhibitors all influenced detection.
KW - beverages
KW - detection
KW - DNA
KW - extraction
KW - food contamination
KW - foods
KW - inoculum
KW - isolation
KW - microbial contamination
KW - oocysts
KW - pH
KW - polymerase chain reaction
KW - techniques
KW - turbidity
KW - Cryptosporidium parvum
KW - Cryptosporidium
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - drinks
KW - food contaminants
KW - hydrogen ion concentration
KW - PCR
KW - potential of hydrogen
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073284765&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: palmer.orlandi@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora.
AU - Xu, H. Y.
AU - Heinze, T. M.
AU - Chen, S. W.
AU - Cerniglia, C. E.
AU - Chen, H. Z.
T2 - Applied and Environmental Microbiology
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2007///
VL - 73
IS - 23
SP - 7759
EP - 7762
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Xu, H. Y.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20083016142. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition
N2 - The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines.
KW - anaerobic conditions
KW - carcinogens
KW - dyes
KW - intestinal microorganisms
KW - intestines
KW - metabolism
KW - metabolites
KW - microbial flora
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - 2,4-dimethylaniline
KW - 4-nitroaniline
KW - aniline
KW - dyestuffs
KW - gut flora
KW - intestinal micro-organisms
KW - microflora
KW - o-toluidine
KW - Sudan dyes
KW - Human Nutrition (General) (VV100)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083016142&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: huizhong.chen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Murine aerosol challenge model of anthrax.
AU - Loving, C. L.
AU - Kennett, M.
AU - Lee, G. M.
AU - Grippe, V. K.
AU - Merkel, T. J.
T2 - Infection and Immunity
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2007///
VL - 75
IS - 6
SP - 2689
EP - 2698
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Loving, C. L.: Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073137420. Publication Type: Journal Article. Language: English. Number of References: 51 ref.
N2 - The availability of relevant and useful animal models is critical for progress in the development of effective vaccines and therapeutics. The infection of rabbits and non-human primates with fully virulent Bacillus anthracis spores provides two excellent models of anthrax disease. However, the high cost of procuring and housing these animals and the specialized facilities required to deliver fully virulent spores limit their practical use in early stages of product development. Conversely, the small size and low cost associated with using mice makes this animal model more practical for conducting experiments in which large numbers of animals are required. In addition, the availability of knockout strains and well-characterized immunological reagents makes it possible to perform studies in mice that cannot be performed easily in other species. Although we, along with others, have used the mouse aerosol challenge model to examine the outcome of B. anthracis infection, a detailed characterization of the disease is lacking. The current study utilizes a murine aerosol challenge model to investigate disease progression, innate cytokine responses, and histological changes during the course of anthrax after challenge with aerosolized spores. Our results show that anthrax disease progression in a complement-deficient mouse after challenge with aerosolized Sterne spores is similar to that described for other species, including rabbits and non-human primates, challenged with fully virulent B. anthracis. Thus, the murine aerosol challenge model is both useful and relevant and provides a means to further investigate the host response and mechanisms of B. anthracis pathogenesis.
KW - animal models
KW - anthrax
KW - cytokines
KW - disease course
KW - experimental infections
KW - histopathology
KW - human diseases
KW - immune response
KW - laboratory animals
KW - Bacillus anthracis
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - disease progression
KW - immunity reactions
KW - immunological reactions
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073137420&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: merkel@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Hall, P.
AU - Ruebush, T. K., II
AU - Williams, A.
AU - Grady, K. K.
AU - Bounngaseng, A.
AU - Nace, D.
AU - Williams, T.
AU - Huber, C.
AU - Galland, G. G.
AU - Barnwell, J. W.
AU - Sullivan, J. J.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2007///
VL - 77
IS - 2
SP - 261
EP - 265
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, and Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 20073218664. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 50-63-8, 54-05-7, 132-73-0, 9035-37-4, 51773-92-3, 53230-10-7. Subject Subsets: Protozoology; Tropical Diseases
N2 - A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
KW - adaptation
KW - antimalarials
KW - antiprotozoal agents
KW - chloroquine
KW - cytochrome b
KW - genes
KW - mefloquine
KW - multiple drug resistance
KW - mutations
KW - strains
KW - Peru
KW - Aotus
KW - Aotus lemurinus
KW - Aotus vociferans
KW - monkeys
KW - Plasmodium falciparum
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Aotus
KW - Andean Group
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Aotus lemurinus griseimembra
KW - Aotus nancymaae
KW - malarone
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073218664&site=ehost-live&scope=site
UR - http://www.ajtmh.org
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibacterial activities of some mosses including Hylocomium splendens from South Western British Columbia.
AU - Kang, S. J.
AU - Kim, S. H.
AU - Liu, P.
AU - Jovel, E.
AU - Towers, G. H. N.
JO - Fitoterapia
JF - Fitoterapia
Y1 - 2007///
VL - 78
IS - 5
SP - 373
EP - 376
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0367-326X
AD - Kang, S. J.: Korea Food and Drug Administration, Jinheungno, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20073188136. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Botanical Pesticides; Aromatic & Medicinal Plants
N2 - The antibacterial activity of methanol extracts of ten moss species and fractions prepared from 80% methanol extract of Hylocomium splendens were evaluated by disk diffusion method. Nine moss species showed antibacterial activity against Gram (+) bacteria, in particular H. splendens and its ethyl acetate fractions showed stronger activity. Enhancement of antibacterial activity against Staphylococci by UV-A light irradiation was demonstrated in the extracts of Bartramia pomiformis, Ceratodon purpureus and Neckera douglasii.
KW - antibacterial properties
KW - Gram positive bacteria
KW - irradiation
KW - medicinal plants
KW - pathogens
KW - pharmacology
KW - plant extracts
KW - ultraviolet radiation
KW - British Columbia
KW - Canada
KW - Bacillus subtilis
KW - Bacteria
KW - Dicranaceae
KW - Enterococcus faecalis
KW - Escherichia coli
KW - Hylocomium splendens
KW - mosses
KW - Pseudomonas aeruginosa
KW - Salmonella typhimurium
KW - Staphylococcus aureus
KW - Bacteria
KW - prokaryotes
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Hylocomium
KW - Hypnaceae
KW - mosses
KW - Bryophyta
KW - plants
KW - eukaryotes
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Staphylococcus
KW - Staphylococcaceae
KW - Dicranaceae
KW - Canada
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bactericidal properties
KW - bacterium
KW - Bartramia pomiformis
KW - Ceratodon
KW - Ceratodon purpureus
KW - Dicranales
KW - Dicranum
KW - Dicranum scoparium
KW - Ditrichaceae
KW - drug plants
KW - E. coli
KW - Eurhynchium pulchellum
KW - Hylocomiaceae
KW - Leucolepsis acanthoneuron
KW - medicinal herbs
KW - Neckera douglasii
KW - officinal plants
KW - Pleurozium
KW - Pleurozium schreberi
KW - Rhacomitrium lanuginosum
KW - Rhytidiadelphus triquetrus
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073188136&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0367326x
UR - email: sapium@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene.
AU - Laassri, M.
AU - Meseda, C. A.
AU - Williams, O.
AU - Merchlinsky, M.
AU - Weir, J. P.
AU - Chumakov, K.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2007///
VL - 79
IS - 6
SP - 791
EP - 802
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Laassri, M.: Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20073128809. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Public Health
N2 - Adverse events associated with the use of live smallpox vaccines have led to the development of a new generation of attenuated smallpox vaccines that are prepared in cultured cells as alternatives. The inability to conduct direct clinical evaluation of their efficacy in humans demands that licensure be based on animal studies and exhaustive evaluation of their in vitro properties. One of the most important characteristics of live viral vaccines is their genetic stability, including reversion of the vaccine strain to more virulent forms, recombination with other viral sequences to produce potentially pathogenic viruses, and genetic drift that can result in decrease of immunogenicity and efficacy. To study genetic stability of an immunoessential vaccinia virus gene in a new generation smallpox vaccine, an advanced oligonucleotide microchip was developed and used to assay for mutations that could emerge in B5R gene, a vaccinia virus gene encoding for a protein that contains very important neutralizing epitopes. This microarray contained overlapping oligonucleotides covering the B5R gene of modified vaccinia virus Ankara (MVA), a well-studied candidate smallpox vaccine. The microarray assay was shown to be able to detect even a single point mutation, and to differentiate between vaccinia strains. At the same time, it could detect newly emerged mutations in clones of vaccinia strains. In the work described here, it was shown that MVA B5R gene was stable after 34 passages in Vero and MRC-5 cells that were proposed for use as cell substrates for vaccine manufacture. Potentially, the proposed method could be used as an identity test and could be extended for the entire viral genome and used to monitor consistency of vaccine production.
KW - assays
KW - genes
KW - mutations
KW - stability
KW - strains
KW - vaccines
KW - Vaccinia virus
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073128809&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: majid.laassri@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiology of acute hepatitis B in the Netherlands in 2004: nationwide survey.
AU - Houdt, R. van
AU - Bruisten, S. M.
AU - Koedijk, F. D. H.
AU - Dukers, N. H. T. M.
AU - Op de Coul, E. L. M.
AU - Mostert, M. C.
AU - Niesters, H. G. M.
AU - Richardus, J. H.
AU - Man, R. A. de
AU - Doornum, G. J. J. van
AU - Hoek, J. A. R. van den
AU - Coutinho, R. A.
AU - Laar, M. J. W. van de
AU - Boot, H. J.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2007///
VL - 79
IS - 7
SP - 895
EP - 901
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Houdt, R. van: GGD Public Health Service, Department of Infectious Diseases, Amsterdam, Netherlands.
N1 - Accession Number: 20073150239. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - To gain insight into hepatitis B virus (HBV) transmission in the Netherlands, epidemiological data and sera were collected from reported cases of acute HBV infections in the Netherlands in 2004. Cases were classified according to mode of transmission. A fragment of the S-gene of HBV (648 bp) was amplified, sequenced, and subjected to phylogenetic analysis. Of the 291 acute HBV cases reported in 2004, 158 (54%) were available for genotyping. Phylogenetic analysis identified 6 genotypes: A (64%), B (3%), C (3%), D (21%), E (5%) and F (5%). Of HBV infected men having sex with men, 86% were infected with genotype A, accounting for 43% of all patients infected with this genotype. There were only three reported cases of injecting drug use of which one was available for sequencing (genotype A). Unlike the genotype A cluster, sequences within the genotype B-E clusters were heterogenic. Within genotype F, several isolates had identical sequences, but patients could not be epidemiologically linked. Sexual transmission, particularly by men having sex with men was the most important transmission route for HBV. Injecting drug use plays a minor role. Genotype A is predominant in the Netherlands, especially among men having sex with men. In addition to imported strains, there seems to be a pool of related but non-identical strains circulating among chronic carriers in the migrant population, from which occasionally new patients are infected, primarily by heterosexual transmission. [A Dutch translation of this article, with an English summary, is published in Nederlands Tijdschrift voor Geneeskunde (2008) 152 (49), pp. 2673-2680].
KW - disease transmission
KW - genes
KW - genotypes
KW - hepatitis B
KW - heterosexual transmission
KW - homosexual transmission
KW - homosexuality
KW - human diseases
KW - injecting drug abuse
KW - injecting drug users
KW - liver
KW - liver diseases
KW - men
KW - molecular epidemiology
KW - molecular genetics
KW - phylogenetics
KW - sexual transmission
KW - women
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - biochemical genetics
KW - homosexuals
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - venereal transmission
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073150239&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: Hein.Boot@rivm.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Photodecomposition of vitamin A and photobiological implications for the skin.
AU - Fu, P. P.
AU - Xia, Q. S.
AU - Yin, J. J.
AU - Cherng, S. H.
AU - Yan, J.
AU - Mei, N.
AU - Chen, T.
AU - Boudreau, M. D.
AU - Howard, P. C.
AU - Wamer, W. G.
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
Y1 - 2007///
VL - 83
IS - 2
SP - 409
EP - 424
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0031-8655
AD - Fu, P. P.: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.
N1 - Accession Number: 20073091347. Publication Type: Journal Article. Language: English. Number of References: 97 ref. Registry Number: 9007-49-2, 68-26-8, 79-81-2. Subject Subsets: Human Nutrition
N2 - Vitamin A (retinol), an essential human nutrient, plays an important role in cellular differentiation, regulation of epidermal cell growth and normal cell maintenance. In addition to these physiological roles, vitamin A has a rich photochemistry. Photoisomerization of vitamin A, involved in signal transduction for vision, has been extensively investigated. The biological effects of light-induced degradation of vitamin A and formation of reactive species are less understood and may be important for light-exposed tissues, such as the skin. Photochemical studies have demonstrated that excitation of retinol or its esters with UV light generates a number of reactive species including singlet oxygen and superoxide radical anion. These reactive oxygen species have been shown to damage a number of cellular targets, including lipids and DNA. Consistent with the potential for damaging DNA, retinyl palmitate has been shown to be photomutagenic in an in vitro test system. The results of mechanistic studies were consistent with mutagenesis through oxidative damage. Vitamin A in the skin resides in a complex environment that in many ways is very different from the chemical environment in solution and in in vitro test systems. Relevant clinical studies or studies in animal models are therefore needed to establish whether the pro-oxidant activity of photoexcited vitamin A is observed in vivo, and to assess the related risks.
KW - DNA
KW - esters
KW - free radicals
KW - in vitro
KW - isomerization
KW - mutagenesis
KW - oxidative stress
KW - photolysis
KW - reactive oxygen species
KW - retinol
KW - retinyl palmitate
KW - reviews
KW - skin
KW - solar radiation
KW - ultraviolet radiation
KW - axerophthol
KW - deoxyribonucleic acid
KW - dermis
KW - DNA damage
KW - photodegradation
KW - photolytic degradation
KW - retinol palmitate
KW - sunlight
KW - vitamin A
KW - vitamin A alcohol
KW - vitamin A palmitate
KW - vitamin A1
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073091347&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/php
UR - email: peter.fu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interference of saturated fats in the determination of low levels of trans fats (below 0.5%) by infrared spectroscopy.
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Milosevic, V.
AU - Milosevic, M.
AU - Azizian, H.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 2007///
VL - 84
IS - 4
SP - 339
EP - 342
CY - Boston; USA
PB - Springer
SN - 0003-021X
AD - Mossoba, M. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-717, Room BE-012, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073111545. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Human Nutrition
N2 - The mandate to label food products with the content of total trans fatty acids has led to an increase in demand for sensitive and accurate methodologies for the rapid quantitation of trans fats. Unfortunately, the latest official infrared (IR) spectroscopic method lacks the required sensitivity. A more sensitive IR procedure that requires the measurement of the height of the second derivative (2D) of the trans absorption band at 966 cm-1 was recently proposed; however, a reported inconsistency at low trans levels between GC (0% of total fat) and IR (1.2% of total fat) results for a fully hydrogenated vegetable oil could not be reconciled, and triggered further investigations. For the first time, we recognize and report the presence of weak interference bands (962-956 cm-1) attributed to saturated fats in the IR spectra of trans fats; these interference bands have an adverse impact on the sensitivity and accuracy of the IR determination at low trans levels (≤0.5% of total fat). Therefore, weak spectral features observed at energies below the one expected for trans bands (966 cm-1) in test samples high in saturated fat (coconut oil and cocoa butter) must not be mistaken for trans bands.
KW - coconut oil
KW - determination
KW - hydrogenated oils
KW - infrared spectroscopy
KW - plant oils
KW - saturated fats
KW - trans fatty acids
KW - cocoa butter
KW - vegetable oils
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073111545&site=ehost-live&scope=site
UR - http://www.springerlink.com
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse event monitoring and multivitamin-multimineral dietary supplements.
AU - Woo, J. J. Y.
A2 - Coates, P. M.
A2 - Dwyer, J. T.
A2 - Thurn, A. L.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2007///
VL - 85
IS - 1
SP - 323S
EP - 324S
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Woo, J. J. Y.: Division of Dietary Supplement Programs, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-810, College Park, MD 20740, USA.
N1 - Accession Number: 20073047032. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition
N2 - A study commissioned by the Food and Drug Administration (FDA) estimated that the FDA is notified of <1% of all adverse events associated with dietary supplements. Among the factors that may contribute to underreporting are that many consumers presume supplements to be safe, use these products without the supervision of a health care professional, and may be unaware that the FDA regulates them. In 2001 an Office of the Inspector General report identified many of the difficulties in evaluating adverse events in a voluntary system and the barriers to effective analysis of these reports to generate possible signals of concern. These include factors such as limited medical information, limited product information, limited manufacturer information, limited information on dietary supplement consumers, and limited ability to analyze trends. In addition, for dietary supplements, vital premarket information (which is available for drug products) is often missing so that possible public health concerns generated by the adverse event reporting system, such as limited clinical information, product identification, and information on consumer use, cannot be adequately assessed. Thus, the FDA is inherently limited in its ability to investigate signals of public health problems generated by the system. However, the FDA can use adverse event reports to identify areas of concern warranting further investigation. The FDA then initiates collaboration with federal partners to identify knowledge gaps in the safety of individual dietary ingredients and products and works with these partners to fill these information gaps to support appropriate regulatory action.
KW - adverse effects
KW - food supplements
KW - minerals
KW - safety
KW - vitamin supplements
KW - vitamins
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - multivitamins
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073047032&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: jason.woo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A detailed mutagenesis study of flavivirus cross-reactive epitopes using West Nile virus-like particles.
AU - Crill, W. D.
AU - Trainor, N. B.
AU - Chang, G. J. J.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 2007///
VL - 88
IS - 4
SP - 1169
EP - 1174
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-1317
AD - Crill, W. D.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Service, PO Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20073109298. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Human flavivirus infections elicit virus species-specific and cross-reactive immune responses. The flavivirus envelope (E) glycoprotein is the primary antigen inducing protective immunity; however, the presence of cross-reactive antibodies in human sera creates problems for serodiagnosis. Using a West Nile virus-like particle system, we performed mutagenesis across all three E protein functional domains to identify epitope determinants for a panel of monoclonal antibodies (mAbs) raised against different flaviviruses and exhibiting diverse patterns of cross-reactivity. Residues within the highly conserved fusion peptide were the only epitope determinants identified and were important not only for broadly cross-reactive mAbs recognizing all of the medically important flavivirus serocomplexes, but also for less-broad, complex-reactive mAbs. Moreover, different substitutions at specific fusion peptide residues produced highly variable effects on antibody reactivity and virus-like particle secretion. These results support and extend the conclusion that the fusion peptide region constitutes an immunodominant epitope stimulating antibodies with diverse patterns of cross-reactivity.
KW - antibodies
KW - antigens
KW - cross reaction
KW - envelope glycoproteins
KW - epitopes
KW - human diseases
KW - immune response
KW - monoclonal antibodies
KW - mutagenesis
KW - peptides
KW - viral structural proteins
KW - Flavivirus
KW - man
KW - West Nile virus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - antigenic determinants
KW - antigenicity
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Morphology of Microorganisms (ZZ392) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073109298&site=ehost-live&scope=site
UR - http://vir.sgmjournals.org
UR - email: wcrill@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women.
AU - Cook, J. A.
AU - Grey, D. D.
AU - Burke-Miller, J. K.
AU - Cohen, M. H.
AU - Vlahov, D.
AU - Kapadia, F.
AU - Wilson, T. E.
AU - Cook, R.
AU - Schwartz, R. M.
AU - Golub, E. T.
AU - Anastosg, K.
AU - Ponathh, C.
AU - Goparajui, L.
AU - Levine, A. M.
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
Y1 - 2007///
VL - 89
IS - 1
SP - 74
EP - 81
CY - New York; USA
PB - Elsevier
SN - 0376-8716
AD - Cook, J. A.: Center on Mental Health Services Research and Policy, Department of Psychiatry M/C 912, University of Illinois at Chicago, 1601 W. Taylor Street M/C 912, Chicago, IL 60612, USA.
N1 - Accession Number: 20073220903. Publication Type: Journal Article. Language: English. Registry Number: 300-62-9, 50-36-2, 53-21-4, 5913-62-2, 5913-65-5, 561-27-3. Subject Subsets: Public Health
N2 - Background - We examined the interaction of illicit drug use and depressive symptoms, and how they affect the subsequent likelihood of highly active antiretroviral therapy (HAART) use among women with HIV/AIDS. Methods - Subjects included 1710 HIV-positive women recruited from six sites in the U.S. including Brooklyn, Bronx, Chicago, Los Angeles, San Francisco/Bay Area, and Washington, DC. Cases of probable depression were identified using depressive symptom scores on the centre for Epidemiologic Studies Depression Scale. Crack, cocaine, heroin, and amphetamine use were self-reported at 6-month time intervals. We conducted multivariate random logistic regression analysis of data collected during 16 waves of semiannual interviews conducted from April 1996 through March 2004. Results - We found an interaction effect between illicit drug use and depression that acted to suppress subsequent HAART use, controlling for virologic and immunologic indicators, socio-demographic variables, time, and study site. Conclusions - This is the first study to document the interactive effects of drug use and depressive symptoms on reduced likelihood of HAART use in a national cohort of women. Since evidence-based behavioural health and antiretroviral therapies for each of these three conditions are now available, comprehensive HIV treatment is an achievable public health goal.
KW - acquired immune deficiency syndrome
KW - amfetamine
KW - antiretroviral agents
KW - antiviral agents
KW - cocaine
KW - crack
KW - depression
KW - drug abuse
KW - drug therapy
KW - heroin
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - immunology
KW - indicators
KW - mental disorders
KW - multiple drug therapy
KW - symptoms
KW - women
KW - California
KW - District of Columbia
KW - Illinois
KW - New York
KW - USA
KW - Washington
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - Pacific Northwest States of USA
KW - AIDS
KW - amphetamine
KW - chemotherapy
KW - combination drug therapy
KW - crack cocaine
KW - diacetylmorphine
KW - diamorphine
KW - drug use
KW - human immunodeficiency virus
KW - human immunodeficiency virus infections
KW - mental illness
KW - psychiatric disorders
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073220903&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T63-4N0XNHK-1&_user=10&_coverDate=06%2F15%2F2007&_rdoc=10&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235019%232007%23999109998%23650339%23FLA%23display%23Volume)&_cdi=5019&_sort=d&_docanchor=&view=c&_ct=14&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f13093d68ff0dba5b31c019a975fcfb4
UR - email: cook@ripco.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluating the use of fatty acid profiles to identify Francisella tularensis.
AU - Whittaker, P.
AU - Day, J. B.
AU - Curtis, S. K.
AU - Fry, F. S.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007///
VL - 90
IS - 2
SP - 465
EP - 469
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Whittaker, P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073085284. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Medical & Veterinary Entomology
N2 - Rapid capillary gas chromatography (GC) with flame-ionization detection was used to determine the cellular fatty acid profiles of Francisella tularensis. Two subspecies of F. tularensis, the live vaccine strain (LVS) derived from holarctica and a novicida strain Utah 112 (U112), were used to compare the extracted fatty acid methyl esters (FAMEs). A data set for the 2 subspecies was prepared using fatty acid profiles of bacteria grown on 2 types of media, Mueller-Hinton and cysteine heart agar supplemented with 5% rabbit blood (CHAB), and harvested at various time intervals (Day 1 to Day 4) with replicates prepared on different days. A total of 204 samples were analyzed. The results showed that these fatty acid quantitative profiles were unique for each of the subspecies and could be used as a fingerprint for the organism. It was determined by this rapid method that approximately 88% of the fatty acid content in both the LVS and U112 strains was made up of 6 saturated fatty acids, namely 10:0, 12:0, 14:0, 16:0, 18:0, and 20:0, and 4 hydroxy fatty acids, namely 10:0 2OH, 16:0 3OH, 17:0 3OH, and 18:0 3OH. Data analysis and determination of clustering were performed by principal component analysis (PCA) and soft independent modeling of class analogy (SIMCA). Both PCA and SIMCA showed clear separation of the LVS and U112 strain and would be useful for prediction of unknowns. It was determined that the incubation time can be reduced from 48 to 24 h, and results are highly predictive for the identification of F. tularensis. In summary, analysis of FAMEs from F. tularensis subspecies LVS and U112 grown on CHAB or Mueller-Hinton media, using a rapid GC method, can provide a sensitive procedure for identification of these organisms.
KW - analytical methods
KW - biochemistry
KW - fatty acid esters
KW - fatty acids
KW - identification
KW - saturated fatty acids
KW - techniques
KW - Francisella tularensis
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073085284&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Rapid gas chromatography/mass spectrometry determination and confirmation of patulin in apple juice.
AU - Marks, H. S.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007///
VL - 90
IS - 3
SP - 879
EP - 883
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Marks, H. S.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021, USA.
N1 - Accession Number: 20073137145. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Registry Number: 149-29-1. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - A gas chromatography/mass spectrometry (GC/MS) method was developed for the quantitative determination and confirmation of patulin extracted from apple juice. Juice is alkalized and extracted with ethyl acetate-hexane, a portion concentrated under N2, then resolubilized in acetonitrile for simple derivatization with bis(trimethylsilyl)trifluoracetamide. Patulin was determined by GC/MS using an electron-impact source and selected ion monitoring of characteristic ions. Spike levels of 20-100 µg/L gave an average recovery of 86%, and 6 ions of sample and standard spectra matched within 10% absolute for confirmation. The limits of quantitation and detection were 10 and 3 µg/L, respectively.
KW - analytical methods
KW - apple juice
KW - determination
KW - food contamination
KW - GC-MS
KW - methodology
KW - patulin
KW - quantitative analysis
KW - analytical techniques
KW - food contaminants
KW - gas chromatography-mass spectrometry
KW - methods
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073137145&site=ehost-live&scope=site
UR - www.aoac.org
UR - email: heidi.marks@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Use of multitoxin immunoaffinity columns for determination of aflatoxins and ochratoxin A in ginseng and ginger.
AU - Trucksess, M. W.
AU - Weaver, C. M.
AU - Oles, C. J.
AU - Rump, L. V.
AU - White, K. D.
AU - Betz, J. M.
AU - Rader, J. I.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007///
VL - 90
IS - 4
SP - 1042
EP - 1049
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20073179603. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Aromatic & Medicinal Plants
N2 - Conditions were optimized for the simultaneous, alkaline, aqueous methanol extraction of aflatoxins (AFL), i.e., B1 (AFB1), B2 (AFB2), G1 (AFG1), and G2 (AFG2), and ochratoxin A (OTA) with subsequent purification, isolation, and determination of the toxins in ginseng and ginger. Powdered roots were extracted with methanol-0.5% NaHCO3 solution (7+3). After shaking and centrifugation, the supernatant was diluted with 100 m M phosphate buffer containing 1% Tween 20 and filtered through glass microfiber filter paper. The filtrate was then passed through an immunoaffinity column, and the toxins were eluted with methanol. The AFL were separated and determined by reversed-phase liquid chromatography (RPLC) with fluorescence detection after postcolumn UV photochemical derivatization. OTA was separated and determined by RPLC with fluorescence detection. Recoveries of AFL added at 2-16 ng/g and OTA added at 1-8 ng/g to ginseng were 72-80 and 86-95%, respectively. Recoveries of AFL and OTA added to ginger were similar to those for ginseng. A total of 39 commercially available ginger products from 6 manufacturers were analyzed. Twenty-six samples were found to be contaminated with AFL at 1-31 ng/g and 29 samples, with OTA at 1-10 ng/g. Ten samples contained no AFL or OTA. Ten ginseng finished products were also analyzed; 3 contained AFL at 0.1 ng/g and 4 contained OTA at levels ranging from 0.4 to 1.8 ng/g. LC/tandem mass spectrometry with multiple-reaction monitoring of 3 collisionally induced product ions from the protonated molecular ions of OTA, AFB1, and AFG1 was used to confirm the identities of the toxins in extracts of the finished products.
KW - aflatoxins
KW - analytical methods
KW - food contamination
KW - ginger
KW - liquid chromatography
KW - mycotoxins
KW - ochratoxins
KW - Panax quinquefolius
KW - Zingiber
KW - Panax
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - analytical techniques
KW - Araliales
KW - food contaminants
KW - fungal toxins
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073179603&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: mary.trucksess@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Direct method for determination of Sudan I in FD&C Yellow No. 6 and D&C Orange No. 4 by reversed-phase liquid chromatography.
AU - Petigara, B. R.
AU - Scher, A. L.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007///
VL - 90
IS - 5
SP - 1373
EP - 1378
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Petigara, B. R.: U.S. Food and Drug Administration, Office of Cosmetics and Colors, HFS-106, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20073241065. Publication Type: Journal Article. Language: English. Number of References: 18 ref.
N2 - A reversed-phase liquid chromatographic method was developed to determine parts-per-million and higher levels of Sudan I,1-(phenylazo)-2-naphthalenol, in the disulfo monoazo color additive FD&C Yellow No. 6 and in a related monosulfo monoazo color additive, D&C Orange No. 4. Sudan I, the corresponding unsulfonated monoazo dye, is a known impurity in these color additives. The color additives are dissolved in water and methanol, and the filtered solutions are directly chromatographed, without extraction or concentration, by using gradient elution at 0.25 mL/min. Calibrations from peak areas at 485 nm were linear. At a 99% confidence level, the limits of determination were 0.008 µg Sudan I/mL (0.4 ppm) in FD&C Yellow No. 6 and 0.011 µg Sudan I/mL (0.00011%) in D&C Orange No. 4. The confidence intervals were 0.202±0.002 µg Sudan I/mL (10.1±0.1 ppm) near the specification level for Sudan I in FD&C Yellow No. 6 and 20.0±0.2 µg Sudan I/mL (0.200±0.002%) near the highest concentration of Sudan I found in D&C Orange No. 4. A survey was conducted to determine Sudan I in 28 samples of FD&C Yellow No. 6 from 17 international manufacturers over 3 years, and in a pharmacology-tested sample. These samples were found to contain undetected levels (16 samples), 0.5-9.7 ppm Sudan I (0.01-0.194 µg Sudan I/mL in analyzed solutions; 11 samples including the pharmacology sample), and ≥10 ppm Sudan I (≥0.2 µg Sudan I/mL; 2 samples). Analyses of 21 samples of D&C Orange No. 4 from 8 international manufacturers over 4 years found Sudan I at undetected levels (8 samples), 0.0005 to <0.005% Sudan I (0.05 to <0.5 µg Sudan I/mL in analyzed solutions; 3 samples, including a pharmacology batch), 0.005 to <0.05% Sudan I (0.5 to <5 µg Sudan I/mL; 9 samples), and 0.18% Sudan I (18 µg Sudan I/mL; 1 sample).
KW - analytical methods
KW - determination
KW - food colourants
KW - HPLC
KW - impurities
KW - techniques
KW - analytical techniques
KW - food colorants
KW - high performance liquid chromatography
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073241065&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: alan.scher@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Work, obesity, and occupational safety and health.
AU - Schulte, P. A.
AU - Wagner, G. R.
AU - Ostry, A.
AU - Blanciforti, L. A.
AU - Cutlip, R. G.
AU - Krajnak, K. M.
AU - Luster, M.
AU - Munson, A. E.
AU - O'Callaghan, J. P.
AU - Parks, C. G.
AU - Simeonova, P. P.
AU - Miller, D. B.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2007///
VL - 97
IS - 3
SP - 428
EP - 436
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Schulte, P. A.: Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073073706. Publication Type: Journal Article. Language: English. Number of References: 148 ref. Subject Subsets: Public Health
N2 - There is increasing evidence that obesity and overweight may be related, in part, to adverse work conditions. In particular, the risk of obesity may increase in high-demand, low-control work environments, and for those who work long hours. In addition, obesity may modify the risk for vibration-induced injury and certain occupational musculoskeletal disorders. We hypothesized that obesity may also be a co-risk factor for the development of occupational asthma and cardiovascular disease that and it may modify the worker's response to occupational stress, immune response to chemical exposures, and risk of disease from occupational neurotoxins. We developed 5 conceptual models of the interrelationship of work, obesity, and occupational safety and health and highlighted the ethical, legal, and social issues related to fuller consideration of obesity's role in occupational health and safety.
KW - asthma
KW - cardiovascular diseases
KW - human diseases
KW - obesity
KW - occupational hazards
KW - risk assessment
KW - risk factors
KW - safety
KW - work
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - fatness
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073073706&site=ehost-live&scope=site
UR - email: pas4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Widening socioeconomic disparities in US childhood mortality, 1969-2000.
AU - Singh, G. K.
AU - Kogan, M. D.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2007///
VL - 97
IS - 9
SP - 1658
EP - 1665
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20073250796. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - Objectives. We examined the extent to which area socioeconomic inequalities in overall and cause-specific mortality among US children aged 1-14 years changed between 1969 and 2000. Methods. We linked a census-based deprivation index to US county mortality data from 1969 to 2000. We used Poisson and log-linear regression and inequality indices to analyze temporal disparities. Results. Despite marked declines in child mortality, socioeconomic gradients (relative mortality risks) in overall child mortality increased substantially during the study period. During 1969-1971, children in the most deprived socioeconomic quintile had 52%, 13%, 69%, and 76% higher risks of all-cause, birth defect, unintentional injury, and homicide mortality, respectively, than did children in the least deprived socioeconomic quintile. The corresponding relative risks increased to 86%, 44%, 177%, 159%, respectively from 1998-2000. Conclusions. Dramatic reductions in mortality among children in all socioeconomic quintiles represent a major public health success. However, children in higher socioeconomic quintiles experienced much larger declines in overall, injury, and natural-cause mortality than did those in more deprived socioeconomic quintiles, which contributed to the widening socioeconomic gap in mortality. Widening disparities in child mortality may reflect increasing polarization among deprivation quintiles in material and social conditions.
KW - accidents
KW - children
KW - congenital abnormalities
KW - crime
KW - deprivation
KW - epidemiology
KW - human diseases
KW - incidence
KW - marginalization
KW - mortality
KW - public health
KW - socioeconomic status
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - death rate
KW - traumas
KW - United States of America
KW - Income and Poverty (EE950)
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073250796&site=ehost-live&scope=site
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects on outpatient and emergency mental health care of strict Medicaid Early Periodic Screening, Diagnosis, and Treatment enforcement.
AU - Snowden, L. R.
AU - Masland, M. C.
AU - Wallace, N. T.
AU - Evans-Cuellar, A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2007///
VL - 97
IS - 11
SP - 1951
EP - 1956
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Snowden, L. R.: School of Social Welfare, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley, 200 Haviland MC 7400, Berkeley, CA 94720-7400, USA.
N1 - Accession Number: 20073298171. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Public Health
N2 - We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed-effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (out-patient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims.
KW - health care
KW - health policy
KW - Medicaid
KW - mental health
KW - outpatient services
KW - California
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Policy and Planning (EE120)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073298171&site=ehost-live&scope=site
UR - email: snowden@berkeley.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of microbial risk assessment in food safety.
AU - Miliotis, M.
JO - SAMJ - South African Medical Journal
JF - SAMJ - South African Medical Journal
Y1 - 2007///
VL - 97
IS - 11(3)
SP - 1211
EP - 1214
CY - Pretoria; South Africa
PB - SAMA Health and Medical Publishing Group
SN - 0256-9574
AD - Miliotis, M.: United States Food and Drug Administration, USA.
N1 - Accession Number: 20083024328. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health; Human Nutrition
N2 - The development of use of risk assessment as a systematic tool for food quality assurance is described in this paper. Some examples of risk assessment studies done by the US FDA on common food contaminants (Listeria monocytogenes, Escherichia coli O157:H7 and Vibrio parahaemolyticus) are provided for analysis. The impact of these findings on public health is discussed.
KW - food contamination
KW - food safety
KW - human diseases
KW - public health
KW - quality controls
KW - risk analysis
KW - risk assessment
KW - USA
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - man
KW - Vibrio parahaemolyticus
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Escherichia coli
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - food contaminants
KW - quality assurance
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083024328&site=ehost-live&scope=site
UR - http://www.samj.org.za
UR - email: marianna.miliotis@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Legal status, emotional well-being and subjective health status of Latino immigrants.
AU - Cavazos-Rehg, P. A.
AU - Zayas, L. H.
AU - Spitznagel, E. L.
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
Y1 - 2007///
VL - 99
IS - 10
SP - 1126
EP - 1131
CY - Washington; USA
PB - National Medical Association
SN - 0027-9684
AD - Cavazos-Rehg, P. A.: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri, USA.
N1 - Accession Number: 20073298875. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - Among the many stresses that undocumented Latino immigrants experience, worries about their legal status and preoccupation with disclosure and deportation can heighten the risk for emotional distress and impaired quality of health. To better document these effects, this study examined the relationship between deportation concern and emotional and physical well-being among a group of Latino immigrants in a midwestern city. One-hundred-fortythree persons were recruited through community sources. Fifty-six participants (39%) expressed concern with seeking services for fear of deportation, while 87 did not endorse this concern. Measures of emotional distress, Hispanic immigrant stress and subjective health status were administered. Results indicate that Latino immigrants with concerns about deportation are at heightened risk of experiencing negative emotional and health states (particularly anger), Hispanic immigrant stress associated with extrafamilial factors and substandard health status. Findings inform policymakers of culturally relevant stressors of undocumented Latino immigrants that help to create and perpetuate the health and mental health disparities of this group.
KW - emotions
KW - ethnic groups
KW - health services
KW - immigrants
KW - immigration
KW - mental health
KW - quality of life
KW - socioeconomic status
KW - wellness
KW - Missouri
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - United States of America
KW - Demography (UU200)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073298875&site=ehost-live&scope=site
UR - http://www.nmanet.org/images/uploads/Journal/OC1126.pdf
UR - email: pcavazos@im.wustl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer.
AU - Kavanaugh, C. J.
AU - Trumbo, P. R.
AU - Ellwood, K. C.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 2007///
VL - 99
IS - 14
SP - 1074
EP - 1085
CY - Cary; USA
PB - Oxford University Press
SN - 0027-8874
AD - Kavanaugh, C. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-830, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073239315. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 502-65-8. Subject Subsets: Human Nutrition; Public Health
N2 - Several studies have reported an inverse association between tomato and/or lycopene intake and the risk of some types of cancer. In 2004, the U.S. Food and Drug Administration (FDA) received two petitions for qualified health claims regarding tomatoes, lycopene, and the risk reduction for some forms of cancer. Health claims that characterize the relationship between a food or food component and a disease or health-related condition require premarket approval by FDA to be included on the labels of conventional foods and dietary supplements. Here we describe FDA's review of the scientific data for tomato and/or lycopene intake with respect to risk reduction for certain forms of cancer. The FDA found no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer. The FDA also found no credible evidence for an association between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer. The FDA found very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers.
KW - breast cancer
KW - cervical cancer
KW - colorectal cancer
KW - endometrial cancer
KW - endometrium
KW - food intake
KW - food supplements
KW - functional foods
KW - health promotion
KW - health protection
KW - human diseases
KW - labelling
KW - lung cancer
KW - lycopene
KW - men
KW - neoplasms
KW - ovarian cancer
KW - ovaries
KW - pancreas
KW - pancreatic cancer
KW - prostate
KW - prostate cancer
KW - reviews
KW - risk
KW - stomach cancer
KW - stomach diseases
KW - tomatoes
KW - women
KW - USA
KW - man
KW - Solanum lycopersicum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - endometrial area
KW - gastric cancer
KW - labeling
KW - labels
KW - Lycopersicon esculentum
KW - United States of America
KW - Crop Produce (QQ050)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073239315&site=ehost-live&scope=site
UR - http://jnci.oxfordjournals.org/
UR - email: claudine.kavanaugh@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biocidal activity of three wood essential oils against Ixodes scapularis (Acari: Ixodidae), Xenopsylla cheopis (Siphonaptera: Pulicidae), and Aedes aegypti (Diptera: Culicidae).
AU - Dolan, M. C.
AU - Dietrich, G.
AU - Panella, N. A.
AU - Montenieri, J. A.
AU - Karchesy, J. J.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 2007///
VL - 100
IS - 2
SP - 622
EP - 625
CY - Lanham; USA
PB - Entomological Society of America
SN - 0022-0493
AD - Dolan, M. C.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20093307537. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Veterinary Science; Medical & Veterinary Entomology; Aromatic & Medicinal Plants; Veterinary Science
N2 - The biocidal activity of three steam distilled wood essential oils - incense cedar, Calocedrus decurrens (Torr.) Florin; Port-Orford-cedar, Chamaecyparis lawsoniana (A. Murr.) Parl.; and western juniper, Juniperus occidentalis (Hook) - were evaluated against adult Aedes aegypti (L.) (Diptera: Culicidae) and Xenopsylla cheopis (Rothchild) (Siphonaptera: Pulicidae) and nymphal Ixodes scapularis Say (Acari: Ixodidae). In vitro laboratory bioassays were conducted to establish baseline dose-mortality data through 24 h. Incense cedar heartwood was the most toxic to all three vector species followed in order of activity by western juniper and Port-Orford-cedar based on LC50 and LC90 values. Ae. aegypti were substantially more susceptible to the oils than either I. scapularis or X. cheopis.
KW - bioassays
KW - essential oils
KW - in vitro
KW - vectors
KW - Acari
KW - Aedes
KW - Aedes aegypti
KW - Calocedrus
KW - Calocedrus decurrens
KW - Chamaecyparis
KW - Chamaecyparis lawsoniana
KW - Culicidae
KW - Diptera
KW - Ixodes
KW - Ixodes scapularis
KW - Ixodidae
KW - Juniperus
KW - Juniperus occidentalis
KW - Libocedrus
KW - Pulicidae
KW - Siphonaptera
KW - Xenopsylla
KW - Xenopsylla cheopis
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - Aedes
KW - Cupressaceae
KW - Pinopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - Libocedrus
KW - Chamaecyparis
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Ixodes
KW - Juniperus
KW - Siphonaptera
KW - Pulicidae
KW - Xenopsylla
KW - incense cedar
KW - mosquitoes
KW - Oriental rat flea
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093307537&site=ehost-live&scope=site
UR - http://www.bioone.org/doi/full/10.1603/0022-0493%282007%29100%5B622%3ABAOTWE%5D2.0.CO%3B2
UR - email: mcd4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Real-time PCR method for Salmonella spp. targeting the stn gene.
AU - Moore, M. M.
AU - Feist, M. D.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2007///
VL - 102
IS - 2
SP - 516
EP - 530
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1364-5072
AD - Moore, M. M.: Seafood Products Research Center, Pacific Regional Laboratory Northwest, US Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021, USA.
N1 - Accession Number: 20073020590. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Human Nutrition
N2 - Aim: To develop a real-time PCR assay for Salmonella spp. targeting the stn gene. Methods and Results: The presence of stn in the Salmonella bongori genome was found by a BLAST with Salmonella enterica stn sequence. Manual alignment of stn sequences showed that Salm. bongori had 88% sequence identity with Salm. enterica. Two primers (stnL-433 and stnR-561) and a probe (stnP-452) were designed to target conserved regions in stn and meet the requirements of a 5′-nuclease assay. The primers and probe were evaluated against 353 isolates, including 255 Salm. enterica representing 158 serotypes, 14 Salm. bongori representing 12 serotypes and 84 non-Salmonella representing 56 species from 31 genera. All isolates were correctly identified, with the exception of three isolates of Citrobacter amalonaticus, which gave false positives. The limit of detection with cultured Salmonella was 3 CFU per reaction. Conclusions: The stn real-time PCR method had 100% inclusivity, 96.4% exclusivity and a level of detection of 3 CFU per reaction for cultured Salmonella spp. Significance and Impact of the Study: The study showed that stn is present in Salm. bongori and is a valid target for both species of Salmonella. The Salmonella stn real-time PCR is a useful method for identifying Salmonella spp.
KW - genes
KW - nucleotide sequences
KW - polymerase chain reaction
KW - serotypes
KW - techniques
KW - Salmonella
KW - Salmonella bongori
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - bacterium
KW - DNA sequences
KW - PCR
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073020590&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jam
UR - email: michelle.moore@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey.
AU - Krieg, E. F., Jr.
T2 - Environmental Research
JO - Environmental Research
JF - Environmental Research
Y1 - 2007///
VL - 104
IS - 3
SP - 374
EP - 382
CY - Orlando; USA
PB - Academic Press
SN - 0013-9351
AD - Krieg, E. F., Jr.: National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073156965. Publication Type: Journal Article. Language: English. Registry Number: 9002-68-0, 7439-92-1, 9002-67-9. Subject Subsets: Public Health
N2 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31.1 µg/dl. The estimated geometric mean was 2.2 µg/dl, and the estimated arithmetic mean was 2.8 µg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1.7 µg/dl for follicle stimulating hormone and 2.8 µg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries.
KW - blood
KW - blood serum
KW - FSH
KW - lead
KW - LH
KW - menopause
KW - middle-aged adults
KW - ovariectomized females
KW - ovariectomy
KW - ovaries
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - follicle stimulating hormone
KW - follitropin
KW - luteinizing hormone
KW - postmenopausal women
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073156965&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4M877KS-1&_user=10&_coverDate=07%2F31%2F2007&_rdoc=8&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236774%232007%23998959996%23660152%23FLA%23display%23Volume)&_cdi=6774&_sort=d&_docanchor=&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5815d64c9df50916b2b578a79c142f24
UR - email: erk3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Accumulation of prion protein in the brain that is not associated with transmissible disease.
AU - Piccardo, P.
AU - Manson, J. C.
AU - King, D.
AU - Ghetti, B.
AU - Barron, R. M.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007///
VL - 104
IS - 11
SP - 4712
EP - 4717
CY - Washington; USA
PB - National Academy of Sciences
SN - 0027-8424
AD - Piccardo, P.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20073069942. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Agricultural Biotechnology; Public Health
N2 - Prion diseases or transmissible spongiform encephalopathies are characterized histopathologically by the accumulation of prion protein (PrP) ranging from diffuse deposits to amyloid plaques. Moreover, pathologic PrP isoforms (PrPSc) are detected by immunoblot analysis and used both as diagnostic markers of disease and as indicators of the presence of infectivity in tissues. It is not known which forms of PrP are associated with infectivity. To address this question, we performed bioassays using human brain extracts from two cases with phenotypically distinct forms of familial prion disease (Gerstmann-Sträussler-Scheinker P102L). Both cases had PrP accumulations in the brain, but each had different PrPSc isoforms. Only one of the brains had spongiform degeneration. Tissue from this case transmitted disease efficiently to transgenic mice (Tg PrP101LL), resulting in spongiform encephalopathy. In contrast, inoculation of tissue from the case with no spongiform degeneration resulted in almost complete absence of disease transmission but elicited striking PrP-amyloid deposition in several recipient mouse brains. Brains of these mice failed to transmit any neurological disease on passage, but PrP-amyloid deposition was again observed in the brains of recipient mice. These data suggest the possible isolation of an infectious agent that promotes PrP amyloidogenesis in the absence of a spongiform encephalopathy. Alternatively, the infectious agent may be rendered nonpathogenic by sequestration in amyloid plaques, or PrP amyloid can seed amyloid accumulation in the brain, causing a proteinopathy that is unrelated to prion disease. Formation of PrP amyloid may therefore not necessarily be a reliable marker of transmissible spongiform encephalopathy infectivity.
KW - brain
KW - human diseases
KW - prion diseases
KW - prion proteins
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - Gerstmann-Straussler-Scheinker
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073069942&site=ehost-live&scope=site
UR - http://www.pnas.org/
UR - email: rona.barron@bbsrc.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pesticide dose estimates for children of Iowa farmers and non-farmers.
AU - Curwin, B. D.
AU - Hein, M. J.
AU - Sanderson, W. T.
AU - Striley, C.
AU - Heederik, D.
AU - Kromhout, H.
AU - Reynolds, S. J.
AU - Alavanja, M. C.
JO - Environmental Research
JF - Environmental Research
Y1 - 2007///
VL - 105
IS - 3
SP - 307
EP - 315
CY - Orlando; USA
PB - Academic Press
SN - 0013-9351
AD - Curwin, B. D.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073286677. Publication Type: Journal Article. Language: English. Registry Number: 1912-24-9, 2921-88-2, 38641-94-0, 1071-83-6, 70393-85-0, 51218-45-2. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology; Public Health; Weeds
N2 - Farm children have the potential to be exposed to pesticides. Biological monitoring is often employed to assess this exposure; however, the significance of the exposure is uncertain unless doses are estimated. In the spring and summer of 2001, 118 children (66 farm, 52 non-farm) of Iowa farm and non-farm households were recruited to participate in a study investigating potential take-home pesticide exposure. Each child provided an evening and morning urine sample at two visits spaced approximately 1 month apart, with the first sample collection taken within a few days after pesticide application. Estimated doses were calculated for atrazine, metolachlor, chlorpyrifos, and glyphosate from urinary metabolite concentrations derived from the spot urine samples and compared to EPA reference doses. For all pesticides except glyphosate, the doses from farm children were higher than doses from the non-farm children. The difference was statistically significant for atrazine (p<0.0001) but only marginally significant for chlorpyrifos and metolachlor (p=0.07 and 0.1, respectively). Among farm children, geometric mean doses were higher for children on farms where a particular pesticide was applied compared to farms where that pesticide was not applied for all pesticides except glyphosate; results were significant for atrazine (p=0.030) and metolachlor (p=0.042), and marginally significant for chlorpyrifos (p=0.057). The highest estimated doses for atrazine, chlorpyrifos, metolachlor, and glyphosate were 0.085, 1.96, 3.16, and 0.34 µg/kg/day, respectively. None of the doses exceeded any of the EPA reference values for atrazine, metolachlor, and glyphosate; however, all of the doses for chlorpyrifos exceeded the EPA chronic population adjusted reference value. Doses were similar for male and female children. A trend of decreasing dose with increasing age was observed for chlorpyrifos.
KW - age
KW - agricultural households
KW - application rates
KW - atrazine
KW - children
KW - chlorpyrifos
KW - estimates
KW - exposure
KW - farm families
KW - glyphosate
KW - herbicide residues
KW - herbicides
KW - insecticide residues
KW - insecticides
KW - metolachlor
KW - pesticide residues
KW - pesticides
KW - sex differences
KW - urine
KW - Iowa
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - chlorpyrifos-ethyl
KW - estimations
KW - United States of America
KW - weedicides
KW - weedkillers
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073286677&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4P77GC5-1&_user=10&_coverDate=11%2F30%2F2007&_rdoc=4&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%236774%232007%23998949996%23670491%23FLA%23display%23Volume)&_cdi=6774&_sort=d&_docanchor=&_ct=19&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9c1ea48c70d0c5fea9702aec6866f479
UR - email: bcurwin@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethical and scientific issues of nanotechnology in the workplace.
AU - Schulte, P. A.
AU - Salamanca-Buentello, F.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007///
VL - 115
IS - 1
SP - 5
EP - 12
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073030110. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decisionmaking about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the (a) identification and communication of hazards and risks by scientists, authorities, and employers; (b) workers' acceptance of risk; (c) selection and implementation of controls; (d) establishment of medical screening programs; and (e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective.
KW - ethics
KW - health
KW - nanotechnology
KW - occupational hazards
KW - occupational health
KW - risk
KW - work
KW - work places
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073030110&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: pschulte@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes.
AU - Li, Z.
AU - Hulderman, T.
AU - Salmen, R.
AU - Chapman, R.
AU - Leonard, S. S.
AU - Young, S. H.
AU - Shvedova, A.
AU - Luster, M. I.
AU - Simeonova, P. P.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007///
VL - 115
IS - 3
SP - 377
EP - 382
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Li, Z.: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
N1 - Accession Number: 20073074663. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Agricultural Biotechnology
N2 - Background: Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT), are emerging as technologically important in different industries. Objective: The unique physical characteristics and the pulmonary toxicity of SWCNTs raised concerns that respiratory exposure to these materials may be associated with cardiovascular adverse effects. Methods: In these studies we evaluated aortic mitochondrial alterations by oxidative stress assays, including quantitative polymerase chain reaction of mitochondrial (mt) DNA and plaque formation by morphometric analysis in mice exposed to SWCNTs. Results: A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice. Furthermore, we found that C57BL/6 mice, exposed to SWCNT (10 and 40 µg/mouse), developed aortic mtDNA damage at 7, 28, and 60 days after exposure. mtDNA damage was accompanied by changes in aortic mitochondrial glutathione and protein carbonyl levels. Because these modifications have been related to cardiovascular diseases, we evaluated whether repeated exposure to SWCNTs (20 µg/mouse once every other week for 8 weeks) stimulates the progression of atherosclerosis in ApoE-/- transgenic mice. Although SWCNT exposure did not modify the lipid profiles of these mice, it resulted in accelerated plaque formation in ApoE-/- mice fed an atherogenic diet. Plaque areas in the aortas, measured by the en face method, and in the brachiocephalic arteries, measured histopathologically, were significantly increased in the SWCNT-treated mice. This response was accompanied by increased mtDNA damage but not inflammation. Conclusions: Taken together, the findings are of sufficient significance to warrant further studies to evaluate the systemic effects of SWCNT under workplace or environmental exposure paradigms.
KW - animal models
KW - atherosclerosis
KW - cardiovascular diseases
KW - environment
KW - exposure
KW - health hazards
KW - laboratory animals
KW - mitochondrial DNA
KW - toxic substances
KW - toxicity
KW - toxicology
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arteriosclerosis
KW - poisons
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Biosensors and Biological Nanotechnology (WW900) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073074663&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: PSimeonova@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vermiculite, respiratory disease, and asbestos exposure in Libby, Montana: update of a cohort mortality study.
AU - Sullivan, P. A.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007///
VL - 115
IS - 4
SP - 579
EP - 585
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Sullivan, P. A.: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20073107804. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 1332-21-4, 1318-00-9. Subject Subsets: Public Health
N2 - Background: Vermiculite from the mine near Libby, Montana, is contaminated with tremolite asbestos and other amphibole fibers (winchite and richterite). Asbestos-contaminated Libby vermiculite was used in loose-fill attic insulation that remains in millions of homes in the United States, Canada, and other countries. Objective: This report describes asbestos-related occupational respiratory disease mortality among workers who mined, milled, and processed the Libby vermiculite. Methods: This historical cohort mortality study uses life table analysis methods to compare the age-adjusted mortality experience through 2001 of 1,672 Libby workers to that of white men in the U.S. population. Results: Libby workers were significantly more likely to die from asbestosis [standardized mortality ratio (SMR)=165.8; 95% confidence interval (CI), 103.9-251.1], lung cancer (SMR=1.7; 95% CI, 1.4-2.1), cancer of the pleura (SMR=23.3; 95% CI, 6.3-59.5), and mesothelioma. Mortality from asbestosis and lung cancer increased with increasing duration and cumulative exposure to airborne tremolite asbestos and other amphibole fibers. Conclusions: The observed dose-related increases in asbestosis and lung cancer mortality highlight the need for better understanding and control of exposures that may occur when homeowners or construction workers (including plumbers, cable installers, electricians, telephone repair personnel, and insulators) disturb loose-fill attic insulation made with asbestos-contaminated vermiculite from Libby, Montana.
KW - asbestos
KW - asbestosis
KW - exposure
KW - lung cancer
KW - mesothelioma
KW - milling
KW - mills
KW - miners
KW - mortality
KW - neoplasms
KW - occupational hazards
KW - vermiculite
KW - Canada
KW - Montana
KW - USA
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Great Plains States of USA
KW - USA
KW - Mountain States of USA
KW - Western States of USA
KW - cancers
KW - death rate
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073107804&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: PSullivan@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Case report: three farmworkers who gave birth to infants with birth defects closely grouped in time and place - Florida and North Carolina, 2004-2005.
AU - Calvert, G. M.
AU - Alarcon, W. A.
AU - Chelminski, A.
AU - Crowley, M. S.
AU - Barrett, R.
AU - Correa, A.
AU - Higgins, S.
AU - Leon, H. L.
AU - Correia, J.
AU - Becker, A.
AU - Allen, R. H.
AU - Evans, E.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007///
VL - 115
IS - 5
SP - 787
EP - 791
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073128617. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - Context: There is little evidence linking adverse reproductive effects to exposure to specific pesticides during pregnancy. Case Presentation: In February 2005, three infants with congenital anomalies were identified in Collier County, Florida, who were born within 8 weeks of one another and whose mothers worked for the same tomato grower. The mothers worked on the grower's Florida farms in 2004 before transferring to its North Carolina farms. All three worked during the period of organogenesis in fields recently treated with several pesticides. The Florida and North Carolina farms were inspected by regulatory agencies, and in each state a large number of violations were identified and record fines were levied. Discussion: Despite the suggestive evidence, a causal link could not be established between pesticide exposures and the birth defects in the three infants. Nonetheless, the prenatal pesticide exposures experienced by the mothers of the three infants is cause for concern. Farmworkers need greater protections against pesticides. These include increased efforts to publicize and comply with both the U.S. Environmental Protections Agency's Worker Protection Standard and pesticide label requirements, enhanced procedures to ensure pesticide applicator competency, and recommendations to growers to adopt work practices to reduce pesticide exposures. Relevance to Professional Practice: The findings from this report reinforce the need to reduce pesticide exposures among farmworkers. In addition, they support the need for epidemiologic studies to examine the role of pesticide exposure in the etiology of congenital anomalies.
KW - congenital abnormalities
KW - exposure
KW - farm workers
KW - human diseases
KW - infants
KW - occupational hazards
KW - pesticides
KW - pregnancy
KW - women
KW - Florida
KW - North Carolina
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Appalachian States of USA
KW - birth defects
KW - congenital malformations
KW - gestation
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073128617&site=ehost-live&scope=site
UR - http://www.ehponline.org
UR - email: jac6@CDC.GOV
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The identification of antibacterial compounds for the development of enhanced media for the detection of foodborne fungi.
AU - Tournas, V. H.
AU - Kohn, J. S.
AU - Katsoudas, E. J.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2007///
VL - 118
IS - 1
SP - 83
EP - 86
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073212308. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 56-75-7, 57-62-5, 64-72-2, 1403-66-3, 1405-41-0. Subject Subsets: Human Nutrition; Plant Pathology; Medical & Veterinary Mycology
N2 - In an effort to identify a more suitable antibiotic for utilization in mycological media, 12 food borne fungal species from various genera including Alternaria alternata, Aspergillus flavus, A. niger, Eurotium chevalieri, Fusarium moniliforme, Penicillium sp., Rhizopus stolonifer, Saccharomyces cerevisiae, Candida tropicalis, Geotrichum candidum, Rhodotorula glutinis and Kluyveromyces thermotolerans along with 21 chloramphenicol-resistant bacterial isolates from fresh produce and ATCC cultures of Pseudomonas aeruginosa, P. fluorescens, E. coli, Pectobacterium carotovorum, Bacillus cereus and Staphylococcus spp. were tested for their abilities to grow on dichloran rose bengal agar containing various levels of gentamicin, chlortetracycline or chloramphenicol. Results indicated that all fungal isolates except for Rh. glutinis and R. stolonifer grew well on all media tested. Rh. glutinis did not grow on media containing gentamicin whereas R. stolonifer produced very restricted or no growth on these media. All bacterial isolates from fresh produce, P. aeruginosa (ATCC 27853) and P. fluorescens (ATCC BAA-477) grew well at 100, 125 and 150 mg chloramphenicol/liter medium, but they did not grow on media containing chlortetracycline (100, 125, or 150 mg/L) or gentamicin (15, 25, or 35 mg/L). P. aeruginosa (ATCC 10145) grew well on media containing chloramphenicol or gentamicin, but not in the presence of chlortetracycline. P. carotovorum, E. coli, B. cereus and Staphylococcus spp. did not grow on any of the selective media tested.
KW - antibacterial agents
KW - antibiotics
KW - chloramphenicol
KW - chlortetracycline
KW - culture media
KW - drug resistance
KW - gentamicin
KW - Alternaria alternata
KW - Aspergillus flavus
KW - Aspergillus niger
KW - Bacillus cereus
KW - Candida tropicalis
KW - Escherichia coli
KW - Eurotium
KW - Geotrichum candidum
KW - Gibberella fujikuroi
KW - Hypocreaceae
KW - Kluyveromyces
KW - Mucoraceae
KW - Pectobacterium carotovorum
KW - Pectobacterium carotovorum subsp. carotovorum
KW - Penicillium
KW - Pseudomonas aeruginosa
KW - Pseudomonas fluorescens
KW - Rhizopus stolonifer
KW - Rhodotorula glutinis
KW - Saccharomyces cerevisiae
KW - Saccharomycetaceae
KW - Staphylococcus
KW - Trichocomaceae
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Candida
KW - Saccharomycetales
KW - Saccharomycetes
KW - Saccharomycotina
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Geotrichum
KW - Dipodascaceae
KW - Gibberella
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Saccharomycetaceae
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Rhizopus
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Rhodotorula
KW - Sporidiobolales
KW - Microbotryomycetes
KW - Pucciniomycotina
KW - Basidiomycota
KW - Saccharomyces
KW - Staphylococcaceae
KW - Eurotium
KW - Kluyveromyces
KW - Pectobacterium
KW - Pectobacterium carotovorum
KW - aureomycin
KW - bacterium
KW - E. coli
KW - Erwinia carotovora subsp. carotovora
KW - Eurotium chevalieri
KW - fungus
KW - Gibberella moniliformis
KW - Hyphomycetes
KW - Kluyveromyces thermotolerans
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbiology (General) (ZZ390)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073212308&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01681605
UR - email: valerie.tournas@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Prevalence of self-reported food allergy in American adults and use of food labels.
AU - Vierk, K. A.
AU - Koehler, K. M.
AU - Fein, S. B.
AU - Street, D. A.
T2 - Journal of Allergy and Clinical Immunology
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2007///
VL - 119
IS - 6
SP - 1504
EP - 1510
CY - New York; USA
PB - Elsevier
SN - 0091-6749
AD - Vierk, K. A.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-728, College Park, MD 20740, USA.
N1 - Accession Number: 20073141826. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Public Health; Soyabeans; World Agriculture, Economics & Rural Sociology
N2 - Background: Few population-based studies in the United States have determined the prevalence of food allergy in adults and the problems these individuals might have with reading food labels. Objective: The objectives of this study are to report the prevalence of self-reported food allergy, to identify the characteristics of food allergy reactions, and to describe the use of labels among adults with food allergy. Methods: Questions from the US Food and Drug Administration's 2001 Food Safety Survey were analyzed to determine the prevalence of food allergy and opinions about food labels in the management of food allergy. Results: The prevalence of self-reported food allergy is 9.1% among all survey respondents, with 5.3% of all respondents reporting a doctor-diagnosed food allergy. The prevalence of food allergy to the 8 most common allergens (peanut, tree nuts, egg, milk, wheat, soybeans, fish, and crustacean shellfish) is self-reported as 2.7% among respondents with doctors' diagnoses. Several label issues, such as words on some ingredient lists being too technical or hard to understand and food labels not always alerting persons to new ingredients, were reported as serious or very serious obstacles for managing an allergy. Conclusion: The prevalence of self-reported doctor-diagnosed food allergy among US adults is 5.3%, and a large portion of adults with food allergy found certain label issues a serious problem for managing their food allergy. Clinical implications: The findings provide a needed source of population-based prevalence data of food allergy among US adults. Label issues identified are useful in understanding the difficulties of managing a food allergy.
KW - adults
KW - consumer protection
KW - consumers
KW - disease prevalence
KW - epidemiology
KW - food allergies
KW - food safety
KW - human diseases
KW - labelling
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - consumer advocacy
KW - food hypersensitivity
KW - labeling
KW - labels
KW - United States of America
KW - Food Economics (EE116) (New March 2000)
KW - Consumer Economics (EE720)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073141826&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00916749
UR - email: katherine.vierk@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nativity/immigrant status, race/ethnicity, and socioeconomic determinants of breastfeeding initiation and duration in the United States, 2003.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Dee, D. L.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007///
VL - 119
IS - Suppl.1
SP - S38
EP - S46
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20073073390. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition; Dairy Science
N2 - OBJECTIVES. Previous research has shown substantial racial/ethnic and socioeconomic disparities in US breastfeeding initiation and duration rates. However, the role of immigrant status in understanding such disparities has not been well studied. In this study we examined the extent to which breastfeeding initiation and duration varied by immigrant status overall and in conjunction with race/ethnicity and socioeconomic status after controlling for other relevant social and behavioral covariates. METHODS. The cross-sectional data for 33121 children aged 0 to 5 years from the 2003 National Survey of Children's Health were used to calculate ever-breastfeeding rates and duration rates at 3, 6, and 12 months by social factors. Multivariate logistic regression was used to estimate relative odds of never breastfeeding and not breastfeeding at 6 and 12 months. RESULTS. More than 72% of mothers reported ever breastfeeding their infants, with the duration rate declining to 52%, 38%, and 16% at 3, 6, and 12 months, respectively. Ever-breastfeeding rates varied greatly among the 12 ethnic-immigrant groups included in this analysis, from a low of 48% for native black children with native parents to a high of 88% among immigrant black and white children. Compared with immigrant Hispanic children with foreign-born parents (the least acculturated group), the odds of never breastfeeding were respectively 2.4, 2.9, 6.5, and 2.4 times higher for native children with native parents (the most acculturated group) of Hispanic, white, black, and other ethnicities. Socioeconomic patterns also varied by immigrant status, and differentials were greater in breastfeeding at 6 months. CONCLUSIONS. Immigrant women in each racial/ethnic group had higher breastfeeding initiation and longer duration rates than native women. Acculturation was associated with lower breastfeeding rates among both Hispanic and non-Hispanic women. Ethnic-immigrant and social groups with lower breastfeeding rates identified herein could be targeted for breastfeeding promotion programs.
KW - attitudes
KW - blacks
KW - breast feeding
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - immigrants
KW - infants
KW - mothers
KW - socioeconomics
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - socioeconomic aspects
KW - United States of America
KW - Demography (UU200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073073390&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The public hand hygiene practices of New Zealanders: a national survey.
AU - Garbutt, C.
AU - Simmons, G.
AU - Patrick, D.
AU - Miller, T.
JO - New Zealand Medical Journal
JF - New Zealand Medical Journal
Y1 - 2007///
VL - 120
IS - 1245
SP - 2810
EP - 2810
CY - Wellington; New Zealand
PB - New Zealand Medical Association
SN - 0028-8446
AD - Garbutt, C.: Auckland Regional Public Health Service, Symonds St, Auckland, New Zealand.
N1 - Accession Number: 20083295895. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - Aim: To survey hand hygiene practices of the New Zealand public. Method: Hand hygiene practices of subjects after they had used the toilet were observed in the washrooms of shopping malls in the cities of Auckland, Hamilton, Wellington, and Christchurch. The frequency and duration of hand hygiene were recorded by gender-appropriate observers. Results: A total of 1200 subjects were observed. The overall frequency of hand washing was 86.7% (95% Confidence Interval [CI] 84.6-88.5). Significant (p<0.0001) gender differences were found with males (81.0%, 95% CI 77.6-84.0) having a lower frequency of hand hygiene than females (92.4%, 95% CI 89.9-94.4). Soap was used by 71.6% (95% CI 68.7-74.3) of subjects but less frequently by males (66.2%) than females (76.5%). Nine out of ten (91.2%, 95% CI 89.3-92.9) subjects who washed their hands, dried them. Males washed (median 8.0 seconds) and dried (median 7.0 seconds) their hands for a shorter period of time than females who washed and dried for medians of 8.8 and 8.0 seconds respectively. The median duration of handwashing (8.6 seconds) and drying with paper towels (7.9 seconds) was well below current recommendations of 20 seconds for each practice. The median duration of use of air towels at 16 seconds was far short of the recommended time of 45 seconds. Conclusion: The New Zealand public appear to practise suboptimal hand hygiene in public washrooms. Future hand hygiene promotion should focus on males; on achieving adequate hand washing (using soap) and drying times; and on promoting drying times appropriate to the chosen method.
KW - hands
KW - hygiene
KW - men
KW - public health
KW - sex differences
KW - women
KW - New Zealand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Environmental Pest Management (HH200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083295895&site=ehost-live&scope=site
UR - http://www.nzma.org.nz/journal/120-1265/2810/content.pdf
UR - email: gregs@adhb.govt.nz
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The response to the trench diseases in World War I: a triumph of public health science.
AU - Atenstaedt, R. L.
JO - Public Health
JF - Public Health
Y1 - 2007///
VL - 121
IS - 8
SP - 634
EP - 639
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Atenstaedt, R. L.: National Public Health Service for Wales and Institute of Medical & Social Care Research (IMSCaR), University of Wales, Bangor, Gwynedd LL57 2PX, UK.
N1 - Accession Number: 20073181581. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - The recent 90-year anniversary of the Battle of the Somme presents an opportunity to examine the public health response to the trench diseases, new conditions which arose in the trenches of World War I. Throughout history, there have been two views of epidemic disease: the configurationist and contagionist perspectives. Most doctors responding to the trench diseases, 'contingent-contagionists', combined these two conceptions of disease. Because of the difficulty of finding a causative organism and the absence of effective treatment, the majority view became that these conditions were a product of the trench environment. Configurationism, with its emphasis on environmental and social determinants, seemed to provide the most obvious approaches for tackling the trench diseases. The diseases were effectively controlled using the tools of public health science: sanitary discipline and a battery of measures, such as improving trench construction, improving the diet, providing protective kit, regular bathing and treating lice infestation. The response demonstrates the triumph of public health science over new medical technologies. It also illustrates the importance of considering all the many determinants of health and of close surveillance, discipline and partnership working to counter ill-health. Although technology, training, doctrine and health beliefs change over time, the interaction between disease and environment remains the core challenge to public health practitioners.
KW - epidemiology
KW - feet
KW - foot diseases
KW - human diseases
KW - nephritis
KW - public health
KW - reviews
KW - rickettsial diseases
KW - soldiers
KW - war
KW - Bartonella quintana
KW - man
KW - Rickettsia
KW - Bartonella
KW - Bartonellaceae
KW - Rhizobiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rickettsiaceae
KW - Rickettsiales
KW - bacterium
KW - Rickettsia quintana
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073181581&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: Robert.Atenstaedt@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute pesticide poisoning in the U.S. retail industry, 1998-2004.
AU - Calvert, G. M.
AU - Petersen, A. M.
AU - Sievert, J.
AU - Mehler, L. N.
AU - Das, R.
AU - Harter, L. C.
AU - Romoli, C.
AU - Becker, A.
AU - Ball, C.
AU - Male, D.
AU - Schwartz, A.
AU - Lackovic, M.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007///
VL - 122
IS - 2
SP - 232
EP - 244
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy., R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093253838. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - Objective. This study was conducted to describe the national magnitude and characteristics of acute pesticide poisoning among workers and customers in retail establishments. Methods. Analyses included retail employees 15-64 years of age and customers with acute pesticide poisoning identified from the Sentinel Event Notification System for Occupational Risks-Pesticides (SENSOR-Pesticides) and California Department of Pesticide Regulation from 1998 to 2004. Pesticide poisoning incidence rates and incidence rate ratios (IRR) were calculated. Results. A total of 325 cases of acute pesticide poisoning were identified. Of these cases, 287 (88%) were retail employees and 38 (12%) were customers. Overall, retail employees had a significantly lower acute pesticide poisoning incidence rate compared with non-agricultural, non-retail employees (IRR=0.53; 95% confidence interval 0.47, 0.59). However, significantly elevated pesticide poisoning incidence rates were observed for four retail occupations (janitors, stock handlers/baggers, bakery/deli clerks, and shipping/receiving handlers). In addition, workers employed in two retail industry sectors (farm supply stores and hardware stores) had significantly elevated acute pesticide poisoning incidence rates. Incidence rates among the retail employees demonstrated a quadratic trend, monotonically decreasing from 1998 to 2000 and monotonically increasing from 2000 to 2003. The rates appear to have leveled off in 2003 and 2004. Conclusions. Preventive measures to decrease acute pesticide poisoning incidence in the retail sector include adoption of unbreakable and tear-resistant container requirements, increased utilization of integrated pest management strategies, and advisement to store managers, employees, and customers about poisoning prevention.
KW - disease incidence
KW - epidemiology
KW - occupational hazards
KW - personnel
KW - pesticides
KW - poisoning
KW - toxic substances
KW - workers
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - poisons
KW - staff
KW - toxicosis
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093253838&site=ehost-live&scope=site
UR - http://www.publichealthreports.org/userfiles/122_2/15_PHR122-2_232-244.pdf
UR - email: jac6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The New Mexico clinical prevention initiative: a statewide prevention partnership.
AU - Espey, D. K.
AU - Baum, S. L.
AU - Jung, A. M.
AU - Kozoll, R. L.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007///
VL - 122
IS - 3
SP - 292
EP - 301
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Espey, D. K.: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Indian Health Service, 5300 Homestead NE, Albuquerque, NM 87110, USA.
N1 - Accession Number: 20093253842. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - The New Mexico Department of Health and the New Mexico Medical Society invited organizations to participate in an initiative to promote clinical preventive services. The Clinical Preventive Initiative (CPI) focuses on the following interventions based on burden of illness, preventability of the condition, cost, current level of services, availability of leadership, and programmatic support: adult pneumococcal vaccination, tobacco use prevention and cessation, mammography screening, colorectal cancer screening, healthier weight, screening and treatment for chlamydia and gonorrhea, screening and intervention for problem drinking, childhood immunization, and prevention of unintended pregnancy. Specific workgroups plan and implement interventions directed at New Mexico medical practices, practitioners, and health-care systems. Several state measures suggest effectiveness of CPI efforts. CPI is a successful public-private collaboration providing an active forum for statewide clinical prevention policy development, an effective mechanism to achieve greater awareness of prevention and improved delivery of preventive services.
KW - alcohol intake
KW - alcoholism
KW - bacterial diseases
KW - breast
KW - breast cancer
KW - children
KW - colon
KW - colorectal cancer
KW - disease prevention
KW - gonorrhoea
KW - health care
KW - health promotion
KW - health services
KW - human diseases
KW - immunization
KW - intestinal diseases
KW - mammography
KW - neoplasms
KW - pregnancy
KW - public health
KW - radiography
KW - rectum
KW - screening
KW - sexually transmitted diseases
KW - smoking cessation
KW - tobacco smoking
KW - vaccination
KW - women
KW - New Mexico
KW - USA
KW - Chlamydia trachomatis
KW - man
KW - Neisseria gonorrhoeae
KW - Streptococcus pneumoniae
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Southwestern States of USA
KW - alcohol consumption
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - breast diseases
KW - breasts
KW - cancers
KW - enteropathy
KW - gestation
KW - gonorrhea
KW - immune sensitization
KW - screening tests
KW - STDs
KW - United States of America
KW - venereal diseases
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093253842&site=ehost-live&scope=site
UR - http://www.publichealthreports.org/userfiles/122_3/3_PHR122-3_292-301.pdf
UR - email: david.espey@ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Integrating hepatitis services into substance abuse treatment programs: new initiatives from SAMHSA.
AU - Kresina, T. F.
AU - Hoffman, K.
AU - Lubran, R.
AU - Clark, H. W.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007///
VL - 122
IS - Suppl.2
SP - 96
EP - 98
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Kresina, T. F.: Division for Pharmacologic Therapies, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Rockville, MD 20857, USA.
N1 - Accession Number: 20093253917. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Public Health
N2 - Injection drug users and clients at substance abuse treatment programmes are at risk for percutaneous transmission of viral hepatitis and acquired immunodeficiency syndrome (AIDS). Thus, it is necessary to promote programmes intended to prevent and control this public health concern. This paper discusses two specific initiatives of the Substance Abuse and Mental Health Services Administrations (SAMHSA) which are intended to advocate community-based substance abuse treatment for individuals and families. The first initiative, Hepatitis Education and Training in Opioid Treatment Programs (HETOTP), funded the American Association for the Treatment of Opioid Dependence (AATOD) to provide on-site training in prevention, care, and treatment of HCV infection for OTP providers. On the one hand, a one-year pilot programme which provides free hepatitis A and B vaccination in substance abuse treatment settings serves as the second initiative. This programme, called Disease Prevention Hepatitis Vaccinations for At-Risk Individuals, asserts that the close follow-up of patients within substance abuse treatment programmes facilitates the provision of preventive services, such as vaccination. The results and feedbacks from these two initiatives enable SAMHSA to coordinate additional demonstration initiatives to build the range of preventive services available within substance abuse outreach and treatment programmes.
KW - acquired immune deficiency syndrome
KW - behaviour
KW - control programmes
KW - disease control
KW - disease transmission
KW - drug abuse
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - injecting drug abuse
KW - injecting drug users
KW - public health
KW - public health services
KW - risk behaviour
KW - viral diseases
KW - viral hepatitis
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - behavior
KW - control programs
KW - drug use
KW - human immunodeficiency virus infections
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - risk behavior
KW - viral infections
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093253917&site=ehost-live&scope=site
UR - http://www.publichealthreports.org/userfiles/122_SUP2/20_PHR122_Sup2_96-98.pdf
UR - email: Thomas.Kresina@samhsa.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Group A streptococcal skin infection outbreak in an abattoir: lessons for prevention.
AU - Humphreys, C. P.
AU - Morgan, S. J.
AU - Walapu, M.
AU - Harrison, G. A. J.
AU - Keen, A. P.
AU - Efstratiou, A.
AU - Neal, S. E.
AU - Salmon, R. L.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2007///
VL - 135
IS - 2
SP - 321
EP - 327
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Humphreys, C. P.: National Public Health Service for Wales, Mid and West Wales, PO Box 108, St David's Park, Job's Well Road, Carmarthen, Carmarthenshire, SA31 3WY, UK.
N1 - Accession Number: 20073056186. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - During a group A streptococcus (GAS) outbreak 21 abattoir workers developed skin infections. The unusual outbreak strain (emm 108.1) was cultured from five workers and four persons in the community with links to the abattoir. The attack rate was 26% in the lamb line. Communal nailbrushes were neither routinely disinfected nor changed, and had high bacterial counts. A cohort study found a higher risk from working in the gutting area and getting cuts on hands more than weekly. Despite high bacterial counts daily nailbrush use had a lower risk, as did always wearing disposable gloves. Working in the gutting area (OR 11.44) and nailbrush use at least once a day (OR 0.04) were significant in the multivariate model. Transmission of infection is likely to have occurred on carcasses. GAS infection among abattoir workers was once common. Simple hygiene measures, such as nailbrush use, may reduce the impact of future outbreaks.
KW - abattoir workers
KW - abattoirs
KW - bacterial diseases
KW - disease prevention
KW - disease transmission
KW - epidemiology
KW - group A streptococci
KW - human diseases
KW - occupational hazards
KW - outbreaks
KW - risk factors
KW - skin diseases
KW - UK
KW - man
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - dermatoses
KW - slaughterhouses
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073056186&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=HYG
UR - email: ciaran.humphreys@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Completeness of notification of tuberculosis in The Netherlands: how reliable is record-linkage and capture-recapture analysis?
AU - Hest, N. A. H. van
AU - Smit, F.
AU - Baars, H. W. M.
AU - Vries, G. de
AU - Haas, P. E. W. de
AU - Westenend, P. J.
AU - Nagelkerke, N. J. D.
AU - Richardus, J. H.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2007///
VL - 135
IS - 6
SP - 1021
EP - 1029
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Hest, N. A. H. van: Tuberculosis Control Section, Department of Infectious Disease Control, Rotterdam Public Health Service, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20073205266. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - The aim of this study was to describe a systematic process of record-linkage, cross-validation, case-ascertainment and capture-recapture analysis to assess the quality of tuberculosis registers and to estimate the completeness of notification of incident tuberculosis cases in The Netherlands in 1998. After record-linkage and cross-validation 1499 tuberculosis patients were identified, of whom 1298 were notified, resulting in an observed under-notification of 13.4%. After adjustment for possible imperfect record-linkage and remaining false-positive hospital cases observed under-notification was 7.3%. Log-linear capture-recapture analysis initially estimated a total number of 2053 (95% CI 1871-2443) tuberculosis cases, resulting in an estimated under-notification of 36.8%. After adjustment for possible imperfect record-linkage and remaining false-positive hospital cases various capture-recapture models estimated under-notification at 13.6%. One of the reasons for the higher than expected estimated under-notification in a country with a well-organized system of tuberculosis control might be that some tuberculosis cases, e.g. extrapulmonary tuberculosis, are managed by clinicians less familiar with notification of infectious diseases. This study demonstrates the possible impact of violation of assumptions underlying capture-recapture analysis, especially the perfect record-linkage, perfect positive predictive value and absent three-way interaction assumptions.
KW - databases
KW - human diseases
KW - monitoring
KW - recording
KW - tuberculosis
KW - Netherlands
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - data banks
KW - surveillance systems
KW - Information and Documentation (CC300)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073205266&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=HYG
UR - email: vanhestr@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A community outbreak of Campylobacter jejuni infection from a chlorinated public water supply.
AU - Richardson, G.
AU - Thomas, D. R.
AU - Smith, R. M. M.
AU - Nehaul, L.
AU - Ribeiro, C. D.
AU - Brown, A. G.
AU - Salmon, R. L.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2007///
VL - 135
IS - 7
SP - 1151
EP - 1158
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Richardson, G.: National Public Health Service, Communicable Disease Surveillance Centre, Abton House, Wedal Rd, Cardiff, CF14 3QX, UK.
N1 - Accession Number: 20073247480. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - An outbreak of Campylobacter jejuni infection occurred in a South Wales Valleys housing estate. Illness in estate residents was associated with tap water consumption [population attributable risk (PAR) 50%, relative risk (RR) 2.53, 95% confidence interval (CI) 1.9-3.37] and residence in the upper estate (PAR 49%, RR 2.44, 95% CI 1.83-3.24). Amongst upper estate residents, rates of diarrhoeal illness increased with rates of water consumption (OR 18, 95% CI 3.5-92.4 for heaviest consumers, χ2 trend P<0.0001). The upper estate received mains water via a covered holding reservoir. A crack in the wall of the holding reservoir was identified. Contamination with surface water from nearby pasture land was the likely cause of this outbreak. Service reservoirs are common in rural communities and need regular maintenance and inspection. The role of water in sporadic cases of campylobacter enteritis may be underestimated.
KW - campylobacteriosis
KW - diarrhoea
KW - disease incidence
KW - drinking water
KW - epidemiology
KW - human diseases
KW - microbial contamination
KW - outbreaks
KW - water supply
KW - waterborne diseases
KW - UK
KW - Wales
KW - Campylobacter jejuni
KW - man
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - diarrhea
KW - scouring
KW - United Kingdom
KW - water supplies
KW - Water Resources (PP200)
KW - Pollution and Degradation (PP600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073247480&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=HYG
UR - email: Roland.Salmon@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
AU - Pogribny, I. P.
AU - Tryndyak, V. P.
AU - Muskhelishvili, L.
AU - Rusyn, I.
AU - Ross, S. A.
A2 - Go, V. L. W.
A2 - Higginbotham, S.
A2 - Vucenik, I.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2007///
VL - 137
IS - 1
SP - 216S
EP - 222S
CY - Bethesda; USA
PB - American Society for Nutrition
SN - 0022-3166
AD - Pogribny, I. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20103007880. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 68 ref. Registry Number: 56-87-1. Subject Subsets: Human Nutrition
N2 - The methyl-deficient model of endogenous hepatocarcinogenesis in rodents is unique in that dietary omission rather than the addition of chemical carcinogens leads to tumor formation. Thus, the biochemical and molecular events predisposing to cancer in this model result from chronic metabolic stress and provide an ideal model system to study progressive alterations that occur during carcinogenesis. Moreover, epigenetic alterations imposed by this diet are believed to be 1 of the main mechanisms responsible for malignant transformation of rat liver cells. In this study we examined the changes in global histone modification patterns in liver during hepatocarcinogenesis induced by methyl deficiency. Feeding animals the methyl-deficient diet (MDD) led to progressive loss of histone H4 lysine 20 trimethylation (H4K20me3), H3 lysine 9 trimethylation (H3K9me3), and histone H3 lysine 9 (H3K9ac) and histone H4 lysine 16 (H4K16ac) acetylation. A considerable decrease of H4K20me3 and H3K9ac was also detected in liver tumors induced by MDD. In contrast, liver tumors displayed an increase in H3K9me3 and H4K16ac. To determine the possible mechanism of alterations of histone modifications, we analyzed the expression of histone-modifying enzymes in liver during hepatocarcinogenesis. The expression of Suv4-20h2 and RIZ1 histone methyltransferases (HMTs) steadily decreased along with the development of liver tumors and reached its lowest level in tumor tissue, whereas the expression of Suv39-h1 HMT and histone acetyltransferase 1 (HAT1) substantially increased in tumors. These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD.
KW - aetiology
KW - animal models
KW - biochemistry
KW - carcinogenesis
KW - carcinogens
KW - deficiency
KW - diets
KW - enzymes
KW - epigenetics
KW - feeding
KW - genetics
KW - human diseases
KW - liver
KW - liver cancer
KW - liver cells
KW - lysine
KW - models
KW - modification
KW - neoplasms
KW - stress
KW - transformation
KW - animals
KW - man
KW - rats
KW - rodents
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Muridae
KW - rodents
KW - cancers
KW - causal agents
KW - etiology
KW - hepatocytes
KW - histone
KW - histone acetyltransferase
KW - Animal Models of Human Nutrition (VV140)
KW - Human Nutrition (General) (VV100)
KW - Human Reproduction and Development (VV060)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103007880&site=ehost-live&scope=site
UR - http://jn.nutrition.org/cgi/content/full/137/1/216S
UR - email: igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA's review of scientific evidence for health claims.
AU - Schneeman, B.
A2 - Pérez-Escamilla, R.
A2 - King, J.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2007///
VL - 137
IS - 2
SP - 493
EP - 494
CY - Bethesda; USA
PB - American Society for Nutrition
SN - 0022-3166
AD - Schneeman, B.: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA.
N1 - Accession Number: 20103007895. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 2 ref. Subject Subsets: Human Nutrition
N2 - Under the Federal Food, Drug, and Cosmetic Act health claims on foods or dietary supplements must be authorized by the FDA. Health claims describe the relationship between a food, food component, or dietary supplement and reducing the risk of a disease or health-related condition. Under interim guidance and enforcement discretion, certain qualified health claims have been provided for on foods and dietary supplements; these claims contain language to qualify the quality and strength of scientific evidence to support the claim because they are not based on significant scientific agreement, which is the standard for health claims authorized by the Federal Food, Drug, and Cosmetic Act. In order to meet its statutory responsibility for evaluation of health claims, the agency has developed guidelines for review of scientific evidence in support of a health claim.
KW - diets
KW - evaluation
KW - food
KW - food supplements
KW - foods
KW - guidelines
KW - health
KW - supplements
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - recommendations
KW - Human Nutrition (General) (VV100)
KW - Food Science and Food Products (Human) (QQ000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103007895&site=ehost-live&scope=site
UR - http://jn.nutrition.org/cgi/content/full/137/2/493
UR - email: barbara.schneeman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature.
AU - Schubauer-Berigan, M. K.
AU - Daniels, R. D.
AU - Fleming, D. A.
AU - Markey, A. M.
AU - Couch, J. R.
AU - Ahrenholz, S. H.
AU - Burphy, J. S.
AU - Anderson, J. L.
AU - Tseng, C. Y.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007///
VL - 139
IS - 5
SP - 799
EP - 808
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0007-1048
AD - Schubauer-Berigan, M. K.: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, MS-R15, 5555 Ridge Ave, Cincinnati, OH 45213, USA.
N1 - Accession Number: 20083130703. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 7440-07-5. Subject Subsets: Public Health
N2 - The aetiology of chronic lymphocytic leukaemia (CLL) is largely unknown. Despite compelling evidence for ionising radiation as a cause of most forms of leukaemia, CLL was not found to be radiogenic in early studies. Herein we describe the recent evidence for causation of CLL by ionising and non-ionising radiation, including a nested case-control study conducted within a cohort of 94 517 US workers at four nuclear weapons facilities and a nuclear naval shipyard. Forty-three cases of CLL deaths and 172 age-matched controls were identified with follow-up up to between 1990 and 1996. Radiation exposure from external sources and plutonium (lagged 10 years) was assessed for each worker, based on monitoring records. The excess relative rate (ERR) was estimated for workers receiving elevated doses compared to unexposed workers, controlling for possible risk factors. The ERR per 10 mSv was -0.020 (95% confidence interval: <0, 0.14) based on all exposed workers. However, for workers receiving <100 mSv, the ERR per 10 mSv was 0.20 (-0.035, 0.96). Recent studies of uranium miners and other populations have shown elevations of CLL possibly associated with ionising and non-ionising radiation. New studies should use incident cases and sufficient latency to account for the expected lengthy induction period for CLL.
KW - B lymphocytes
KW - chemical workers
KW - death
KW - exposure
KW - human diseases
KW - ionizing radiation
KW - mortality
KW - nuclear power stations
KW - occupational hazards
KW - occupational health
KW - plutonium
KW - radiation
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - B cells
KW - chronic lymphocytic leukaemia
KW - death rate
KW - nuclear power plants
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083130703&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1365-2141.2007.06843.x
UR - email: zcg3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Colorado Tick Fever viral RNA in acute human serum samples by a quantitative real-time RT-PCR assay.
AU - Lambert, A. J.
AU - Kosoy, O.
AU - Velez, J. O.
AU - Russell, B. J.
AU - Lanciotti, R. S.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2007///
VL - 140
IS - 1/2
SP - 43
EP - 48
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Lambert, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampert Road, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20073098098. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 63231-63-0. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - A quantitative real-time RT-PCR assay for the detection of Colorado Tick Fever (CTF) viral RNA in human clinical samples is presented. The sensitivity of this assay has been shown to be greater than that of the isolation of virus in Vero cells by standard plaque assay in a direct comparison. The specificity of the CTF quantitative real-time RT-PCR assay was determined by the exclusive detection of CTF viral RNAs when applied to a diverse panel of CTF viral isolates and reference strain agents known to circulate in areas of CTF virus transmission. Lastly, the quantitative real-time RT-PCR assay demonstrated exceptional sensitivity for the detection of CTF viral RNA in acute human serum. The quantitative real-time RT-PCR assay is efficient, sensitive and specific and as such is useful for the detection of CTF viral RNA in the diagnostic or research laboratory.
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - reverse transcriptase PCR
KW - RNA
KW - tickborne diseases
KW - USA
KW - Colorado tick fever virus
KW - Dermacentor andersoni
KW - man
KW - Orbivirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Dermacentor
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - reverse transcriptase polymerase chain reaction
KW - ribonucleic acid
KW - RT-PCR
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073098098&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: ahk7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 146
IS - 5
SP - 361
EP - 364
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073062943. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 33 ref. Registry Number: 50-78-2. Subject Subsets: Public Health
N2 - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendation and supporting scientific evidence on routine use of aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer. The complete information on which this statement is based, including evidence tables and references, is available in the accompanying articles in this issue and on the USPSTF Web site (http://www.preventiveservices.ahrq.gov). The USPSTF is redesigning its recommendation statement in response to feedback from primary care clinicians. The USPSTF plans to release, later in 2007, a new, updated recommendation statement that is easier to read and incorporates advances in USPSTF methodology. The recommendation statement below is an interim version that combines existing language and elements with a new format. Although the definitions of grades remain the same, other elements have been revised.
KW - aspirin
KW - chemoprophylaxis
KW - disease prevention
KW - guidelines
KW - human diseases
KW - neoplasms
KW - non-steroidal antiinflammatory agents
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - acetylsalicylic acid
KW - cancers
KW - NSAIDS
KW - recommendations
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073062943&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - How to read the new recommendation statement: methods update from the U.S. Preventive Services Task Force.
AU - Barton, M. B.
AU - Miller, T.
AU - Wolff, T.
AU - Petitti, D.
AU - Lefevre, M.
AU - Sawaya, G.
AU - Yawn, B.
AU - Guirguis-Blake, J.
AU - Calonge, N.
AU - Harris, R.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 2
SP - 123
EP - 127
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Barton, M. B.: U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073161208. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Since 2001, the U.S. Preventive Services Task Force (USPSTF) has worked to refine its methods of evidence review and assessment and to create more usable documents in response to clinicians' needs. These changes have resulted in a revised grading system, as well as a new format and new language for the recommendation statement. This paper focuses on the changes to and the new look of the USPSTF recommendation statement. The new recommendation statement comprises 9 sections. Important changes include standardization of the format of the summary statement to specify what service is being recommended in what population; standardization of the headings in the rationale section; a change in the wording of the grade C recommendation and the I statement; and a new section, called "Other Considerations," in which salient issues related to cost-effectiveness, mandates, and other implementation issues are described.
KW - disease prevention
KW - documentation
KW - guidelines
KW - health services
KW - human diseases
KW - methodology
KW - physicians
KW - reviews
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - doctors
KW - methods
KW - recommendations
KW - United States of America
KW - Information and Documentation (CC300)
KW - Health Services (UU350)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161208&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for chlamydial infection: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 2
SP - 128
EP - 134
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073161209. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - Description: Update of 2001 U.S. Preventive Services Task Force (USPSTF) recommendations about screening sexually active adolescents and adults for chlamydial infection. Methods: The USPSTF weighed the benefits (improved fertility, pregnancy outcomes, and infection transmission) and harms (anxiety, relationship problems, and unnecessary treatment of false-positive results) of chlamydial screening identified in their 2001 recommendations and the accompanying systematic review of English-language articles published between July 2000 and July 2005. Recommendations: Screen for chlamydial infection in all sexually active non-pregnant young women age 24 years or younger and for older nonpregnant women who are at increased risk. (A recommendation) Screen for chlamydial infection in all pregnant women age 24 years or younger and in older pregnant women who are at increased risk. (B recommendation) Do not routinely screen for chlamydial infection in women age 25 years or older, regardless of whether they are pregnant, if they are not at increased risk. (C recommendation) Current evidence is insufficient to assess the balance of benefits and harms of screening for chlamydial infection for men. (I statement).
KW - adolescents
KW - adults
KW - children
KW - disease prevention
KW - guidelines
KW - health services
KW - human diseases
KW - reviews
KW - screening
KW - sexually transmitted diseases
KW - women
KW - USA
KW - Chlamydia
KW - man
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - recommendations
KW - screening tests
KW - STDs
KW - teenagers
KW - United States of America
KW - venereal diseases
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161209&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for chlamydial infection: an evidence update for the U.S. Preventive Services Task Force.
AU - Meyers, D. S.
AU - Halvorson, H.
AU - Luckhaupt, S.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 2
SP - 135
EP - 142
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Meyers, D. S.: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073161210. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Background: Chlamydial infection is the most common sexually transmitted bacterial infection in the USA, with an estimated 3 million new cases annually. In 2001, the U.S. Preventive Services Task Force (USPSTF) recommended that clinicians screen all sexually active women at increased risk for infection for Chlamydia trachomatis. Purpose: To summarize a systematic evidence review commissioned by the USPSTF in preparation for an update of its 2001 recommendation. Data Sources: English-language articles identified in PubMed between July 2000 and July 2005. Additional articles were identified by bibliographic reviews and discussions with experts. A total of 452 articles were identified. Study Selection: Explicit inclusion and exclusion criteria were used for each of 3 key questions. For studies of screening in non-pregnant women at increased risk, review was limited to randomized, controlled trials. For other groups, both randomized, controlled studies and nonrandomized, prospective, controlled studies were included. Data Abstraction: Using standardized forms, staff of the Agency for Healthcare Research and Quality abstracted data on study design, setting, sample, randomization, blinding, results, and harms. Data Synthesis: Only 1 new study met inclusion criteria. This poor-quality study of the effectiveness of screening for chlamydial infection among nonpregnant women at increased risk found that screening was associated with a lower prevalence of chlamydial infection and fewer reported cases of pelvic inflammatory disease at 1-year follow-up. Limitations: No new evidence was found on screening in pregnant women, nonpregnant women not at increased risk, or men. Conclusions: A systematic review found a small amount of new evidence to inform the USPSTF as it updates its recommendations regarding screening for chlamydial infection. There are large gaps in the evidence about screening men to improve health outcomes in women.
KW - bacterial diseases
KW - human diseases
KW - pelvic inflammatory disease
KW - reviews
KW - risk factors
KW - screening
KW - sexually transmitted diseases
KW - women
KW - USA
KW - Chlamydia trachomatis
KW - man
KW - Chlamydia
KW - Chlamydiaceae
KW - Chlamydiales
KW - Chlamydiae
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - screening tests
KW - STDs
KW - United States of America
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161210&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Counseling about proper use of motor vehicle occupant restraints and avoidance of alcohol use while driving: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 3
SP - 187
EP - 193
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20073177137. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Description: An assessment of the independent effectiveness of primary care interventions to increase the proper use of child safety seats, booster seats, and lap-and-shoulder belts to prevent motor vehicle occupant injuries (MVOIs) and to prevent alcohol-related MVOIs in adolescents and adults. Methods: The U.S. Preventive Services Task Force reviewed evidence on the effectiveness of counselling in primary care about the proper use of child restraints in motor vehicles to prevent injury, as well as evidence on the impact of primary care counselling to prevent alcohol-related MVOIs in adolescents and adults. This included information gathered in the process of making their 1996 recommendation, as well as the accompanying systematic review of English-language articles published through 2005. Recommendation: Current evidence is insufficient to assess the incremental benefits, beyond the efficacy of legislation and community-based interventions, of counselling in the primary care setting to improve rates of proper use of motor vehicle occupant restraints. (I statement).
KW - accident prevention
KW - adolescents
KW - adults
KW - alcohol intake
KW - alcoholic beverages
KW - children
KW - counselling
KW - guidelines
KW - motor cars
KW - safety devices
KW - traffic accidents
KW - traffic safety
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - automobiles
KW - counseling
KW - recommendations
KW - teenagers
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073177137&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Brief communication: characteristics of spontaneous cases of tuberculosis associated with infliximab.
AU - Raval, A.
AU - Akhavan-Toyserkani, G.
AU - Brinker, A.
AU - Avigan, M.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 10
SP - 699
EP - 702
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Raval, A.: U. S. Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20073279205. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Background: A warning for tuberculosis was added to the approved labeling for infliximab in October 2001. Objective: To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Design: Case series. Setting: Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. Patients: 130 patients with infliximab-associated tuberculosis. Measurements: Clinical and laboratory data. Results: The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n=89), history of latent or active tuberculosis (n=33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n=25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab. Limitation: Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Conclusion: Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab.
KW - adverse effects
KW - drug therapy
KW - human diseases
KW - immunocompromised hosts
KW - immunosuppressive agents
KW - opportunistic infections
KW - risk factors
KW - tuberculosis
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterium
KW - chemotherapy
KW - immunosuppressants
KW - infliximab
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073279205&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for high blood pressure: U.S. Preventive Services Task Force reaffirmation recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 11
SP - 783
EP - 786
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083005803. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 6 ref. Subject Subsets: Public Health
N2 - Description: Reaffirmation of the 2003 U.S. Preventive Services Task Force statement about screening for high blood pressure. Methods: The U.S. Preventive Services Task Force did a targeted literature search for evidence on the benefits and harms of screening for high blood pressure. Recommendation: Screen for high blood pressure in adults age 18 years or older. (Grade A recommendation).
KW - blood pressure
KW - cardiovascular diseases
KW - diagnosis
KW - epidemiology
KW - human diseases
KW - hypertension
KW - integer programming
KW - public health
KW - screening
KW - surveillance
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - discrete programming
KW - high blood pressure
KW - screening tests
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083005803&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for carotid artery stenosis: U.S. Preventive Services Task Force Recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007///
VL - 147
IS - 12
SP - 854
EP - 859
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083005800. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - Description: Update of the 1996 U.S. Preventive Services Task Force statement about screening for asymptomatic carotid artery stenosis (CAS) in the general population. Methods: The U.S. Preventive Services Task Force examined the evidence on the natural history of CAS; systematic reviews of the accuracy of screening tests; observational studies of the harms of screening and treatment of asymptomatic CAS; and randomized, controlled trials of the benefits of treatment for CAS with carotid endarterectomy.
KW - diagnosis
KW - epidemiology
KW - human diseases
KW - screening
KW - stenosis
KW - surveillance
KW - vascular diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - blood vessel disorders
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083005800&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enteric caliciviruses in domestic pigs in Hungary.
AU - Reuter, G.
AU - Bíró, H.
AU - Szucs, G.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2007///
VL - 152
IS - 3
SP - 611
EP - 614
CY - Wien; Austria
PB - Springer-Verlag
SN - 0304-8608
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20073223053. Publication Type: Journal Article. Language: English. Subject Subsets: Veterinary Science; Veterinary Science; Public Health; Pig Science
N2 - Caliciviruses closely related to human norovirus and sapovirus were recently detected in domestic pigs, causing discussions about the animal reservoir and the potential for zoonotic transmission to humans. To detect porcine caliciviruses, 17 fecal samples collected on two swine farms in southwestern Hungary were tested by reverse transcription-polymerase chain reaction. Three (17.6%) samples were positive for caliciviruses. This study confirms the presence of caliciviruses, both porcine sapovirus (genus Sapovirus) and porcine norovirus (genus Norovirus), in domestic pigs in Hungary and provides additional information on the viral genetic diversity and relationship to viruses referred to as human caliciviruses.
KW - disease transmission
KW - genetic diversity
KW - human diseases
KW - zoonoses
KW - Hungary
KW - man
KW - Norovirus
KW - pigs
KW - Sapovirus
KW - Vesivirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - hogs
KW - swine
KW - winter vomiting disease
KW - winter vomiting virus
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073223053&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/n154241h17j33t6p/?p=3a575b1fd6704774a35aa72eba43b0be&pi=15
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Air pollution sources and childhood asthma attacks in Cataño, Puerto Rico.
AU - Loyo-Berríos, N. I.
AU - Irizarry, R.
AU - Hennessey, J. G.
AU - Tao, X. G. G.
AU - Matanoski, G.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2007///
VL - 165
IS - 8
SP - 927
EP - 935
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Loyo-Berríos, N. I.: Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, US Department of Health and Human Services, 1350 Piccard Drive, HFZ-541, Rockville, MD 20850, USA.
N1 - Accession Number: 20073089391. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Tropical Diseases
N2 - Asthma prevalence in the Cataño Air Basin of Puerto Rico is 27% for children aged 13-14 years and 45% for children aged 5-6 years. There is concern that these rates are related to air pollution. The authors conducted a nested case-control study to evaluate whether proximity to air pollution point sources was associated with increased risk of asthma attacks. For 1997-2001, 1,382 asthma-related medical visits (International Classification of Diseases, Ninth Revision, codes 493 and 493.9) in children under 17 were identified through health insurance claims. Controls were children with no asthma attacks who were randomly selected from enrollees in two health insurance companies by incidence density sampling (1:5) and matched to cases on gender, age, insurance company, and event date. The distance from a point source to the subject's residence area represented a surrogate exposure measurement. Odds ratios for a 1-km decrease in distance were obtained by conditional logistic regression. Risk of asthma attack was associated with residing near a grain mill (odds ratio (OR)=1.35), petroleum refinery (OR=1.44), asphalt plant (OR=1.23), or power plant (OR=1.28) (all p's<0.05). Residence near major air emissions sources (>100 tons/year) increased asthma attack risk by 108% (p<0.05). These results showed that proximity to some air pollution sources is associated with increased risks of asthma attacks.
KW - air pollution
KW - asthma
KW - children
KW - exposure
KW - human diseases
KW - respiratory hypersensitivity
KW - risk factors
KW - Puerto Rico
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - America
KW - Latin America
KW - atmospheric pollution
KW - Porto Rico
KW - Pollution and Degradation (PP600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073089391&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: nilsa.loyo-berrios@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México.
AU - Longnecker, M. P.
AU - Gladen, B. C.
AU - Cupul-Uicab, L. A.
AU - Romano-Riquer, S. P.
AU - Weber, J. P.
AU - Chapin, R. E.
AU - Hernández-Ávila, M.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2007///
VL - 165
IS - 9
SP - 1015
EP - 1022
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Longnecker, M. P.: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
N1 - Accession Number: 20083233970. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 72-55-9, 50-29-3. Subject Subsets: Protozoology; Medical & Veterinary Entomology; Rural Development; Tropical Diseases
N2 - The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital distance serves as a measure of fetal androgen action. The authors designed the present study to examine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males. A cross-sectional study of 781 newly delivered male infants was conducted in 2002-2003 in Chiapas, México, where DDT had recently been used for malaria control. Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother's blood was drawn. In this population, the range of serum DDE levels was large (0.8-398 µg/liter). The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth. If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes.
KW - animal experiments
KW - animal models
KW - control programmes
KW - DDE
KW - DDT
KW - degradation
KW - disease control
KW - exposure
KW - fetus
KW - human diseases
KW - infants
KW - insecticides
KW - malaria
KW - neonates
KW - pesticides
KW - Mexico
KW - man
KW - Plasmodium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - APEC countries
KW - Developing Countries
KW - Latin America
KW - America
KW - North America
KW - OECD Countries
KW - Threshold Countries
KW - animal research
KW - control programs
KW - dicophane
KW - foetus
KW - newborn infants
KW - p,p'-dichlorodiphenyldichloroethylene
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Health Services (UU350)
KW - Pesticides and Drugs (General) (HH400)
KW - Human Health and the Environment (VV500)
KW - Human Reproduction and Development (VV060)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083233970&site=ehost-live&scope=site
UR - http://aje.oxfordjournals.org/cgi/content/full/165/9/1015
UR - email: longnec1@niehs.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Malathion exposure and the incidence of cancer in the Agricultural Health Study.
AU - Bonner, M. R.
AU - Coble, J.
AU - Blair, A.
AU - Freeman, L. E. B.
AU - Hoppin, J. A.
AU - Sandler, D. P.
AU - Alavanja, M. C. R.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2007///
VL - 166
IS - 9
SP - 1023
EP - 1034
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Bonner, M. R.: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 2160 Executive Blvd., Bethesda, MD 20892-7240, USA.
N1 - Accession Number: 20073275812. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 121-75-5. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio=0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance.
KW - disease incidence
KW - epidemiology
KW - exposure
KW - farm workers
KW - human diseases
KW - malathion
KW - melanoma
KW - neoplasms
KW - non-Hodgkin's lymphoma
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - United States of America
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073275812&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: alavanjm@exchange.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A nested case-control study of lung cancer risk and ionizing radiation exposure at the Portsmouth Naval Shipyard.
AU - Yiin, J. H.
AU - Silver, S. R.
AU - Daniels, R. D.
AU - Zaebst, D. D.
AU - Seel, E. A.
AU - Kubale, T. L.
JO - Radiation Research
JF - Radiation Research
Y1 - 2007///
VL - 168
IS - 3
SP - 341
EP - 348
CY - Great Falls; USA
PB - Radiation Research Society
SN - 0033-7587
AD - Yiin, J. H.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20073275212. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Results have been inconsistent between studies of lung cancer risk and ionizing radiation exposures among workers at the Portsmouth Naval Shipyard (PNS). The purpose of this nested case-control study was to evaluate the relationship between lung cancer risk and external ionizing radiation exposure while adjusting for potential confounders that included gender, radiation monitoring status, smoking habit surrogates (socioeconomic status and birth cohort), welding fumes and asbestos. By incidence density sampling, we age-matched 3291 controls selected from a cohort of 37 853 civilian workers employed at PNS between 1952 and 1992 with 1097 lung cancer deaths from among the same cohort. Analyses using conditional logistic regression were conducted in various model forms: log-linear (main), linear excess relative risk (ERR), and categorical. Lung cancer risk was positively associated with occupational dose (OR=1.02 at 10 mSv; 95% CI 0.99- 1.04) but flattened after the inclusion of work-related medical X-ray doses (OR=1.00; 95% CI 0.98-1.03) in multivariate analyses. Similar risk estimates were observed in the linear ERR model at 10 mSv of cumulative exposure with a 15-year lag.
KW - exposure
KW - human diseases
KW - ionizing radiation
KW - lung cancer
KW - lungs
KW - neoplasms
KW - risk factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073275212&site=ehost-live&scope=site
UR - http://www.rrjournal.org/perlserv/?request=get-abstract&doi=10.1667%2FRR0843.1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Urinary excretion of acrylamide and metabolites in Fischer 344 rats and B6C3F1 mice administered a single dose of acrylamide.
AU - Doerge, D. R.
AU - Twaddle, N. C.
AU - Boettcher, M. I.
AU - McDaniel, L. P.
AU - Angerer, J.
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007///
VL - 169
IS - 1
SP - 34
EP - 42
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0378-4274
AD - Doerge, D. R.: National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20073213230. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2. Subject Subsets: Animal Nutrition
N2 - Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in mice and rats. AA is also formed during cooking in many commonly consumed starchy foods. Our previous toxicokinetic investigations of AA and its genotoxic metabolite, glycidamide (GA), in rodents showed that AA is highly bioavailable from oral routes of administration, is widely distributed to tissues, and that the dietary route, in particular, favours metabolism to GA. Formation and accumulation of mutagenic GA-DNA adducts in many tissues support the hypothesis that AA is carcinogenic in rodent bioassays through metabolism to GA. The current investigation describes the quantification of 24 h urinary metabolites, including free AA and GA and their mercapturic acid conjugates (AAMA and GAMA, respectively), using LC/MS/MS in F344 rats and B6C3F1 mice following a dose of 0.1 mg/kg bw given by intravenous, gavage, and dietary routes of administration. Similar groups of rodents were used previously for serum/tissue toxicokinetic and adduct determinations (DNA and haemoglobin). The goal was to investigate relationships between urinary and circulating biomarkers of exposure, toxicokinetic parameters for AA and GA, and tissue GA-DNA adducts in rodents from single doses of AA. Significant linear correlations were observed between urinary levels of AA with AAMA and GA with GAMA in the current data sets for rats and mice. Concentrations of AA and AAMA correlated significantly with average AUC values determined previously for AA in groups of rats and mice similarly dosed with AA. Urinary GA and GAMA concentrations showed significant correlations with average AUC values for GA and liver GA-DNA adducts determined previously in rats and mice similarly dosed with AA. Despite statistical significance, considerable inter-animal variability was observed in all urinary measurements, which limited the degree of correlation with either average toxicokinetic or biomarker data collected from different groups of animals. These results suggest that urinary measurements of AA and its metabolites may be useful for prediction of internal exposures to AA and GA.
KW - animal models
KW - bioassays
KW - cooking
KW - diets
KW - DNA
KW - excretion
KW - foods
KW - genotoxicity
KW - haemoglobin
KW - liver
KW - metabolites
KW - models
KW - techniques
KW - urine
KW - mice
KW - rats
KW - rodents
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxyribonucleic acid
KW - hemoglobin
KW - Food Processing (General) (QQ100)
KW - Human Nutrition (General) (VV100)
KW - Animal Nutrition (General) (LL500)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073213230&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-4MKCGXW-1&_user=10&_coverDate=02%2F28%2F2007&_rdoc=7&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235177%232007%23998309998%23643959%23FLA%23display%23Volume)&_cdi=5177&_sort=d&_docanchor=&view=c&_ct=14&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=cc4e530c0af4ac9646826f822df7950c
UR - email: daniel.doerge@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Impact of mobile radiographic screening on tuberculosis among drug users and homeless persons.
AU - Vries, G. de
AU - Hest, R. A. H. van
AU - Richardus, J. H.
T2 - American Journal of Respiratory and Critical Care Medicine
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
Y1 - 2007///
VL - 176
IS - 2
SP - 201
EP - 207
CY - New York; USA
PB - American Thoracic Society
SN - 1073-449X
AD - Vries, G. de: Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20073174201. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - Rationale: In 2002, a mobile radiographic screening program was started in Rotterdam to respond to high rates of tuberculosis (TB) among illicit drug users and homeless persons. Objectives: We studied trends and characteristics of TB among these risk groups and assessed the impact of the screening program on transmission, using molecular typing. Methods: Description of trends, and of demographic and disease-related characteristics of tuberculosis cases among these risk groups between 1993 and 2005. TB was considered to result from recent transmission if the mycobacterial DNA fingerprints of cases were identical to those of other cases in the risk groups in the previous 2 years. Measurements and Main Results: During the study period, 206 individuals with TB among illicit drug users and homeless persons were notified, representing 11.4% of the total case load of 1,811 in Rotterdam. The annual number of tuberculosis cases declined from 24 at the start of the screening program to 11 cases in 2005. The screening program identified 28 cases (a prevalence rate of 327 per 100,000 radiographs), of which 12 were smear positive. In 1997-2002, more than 80% of the illicit drug users or homeless persons with TB were infected with one of the Mycobacterium tuberculosis strains prevalent among these risk groups. After nearly 4 years of systematic radiographic screening this proportion declined to 45% in 2005. Conclusions: DNA fingerprinting can be a useful tool to evaluate the impact of a TB screening program. We advocate that screening of illicit drug users and homeless persons should be continued to prevent a resurgence of TB.
KW - disease incidence
KW - disease prevalence
KW - DNA
KW - DNA fingerprinting
KW - drug abuse
KW - drug users
KW - epidemiology
KW - homeless people
KW - human diseases
KW - molecular epidemiology
KW - radiography
KW - risk groups
KW - screening
KW - tuberculosis
KW - Netherlands
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - deoxyribonucleic acid
KW - drug abusers
KW - drug use
KW - screening tests
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073174201&site=ehost-live&scope=site
UR - http://www.thoracic.org
UR - email: devriesg@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth.
AU - Cowley, S. C.
AU - Sedgwick, J. D.
AU - Elkins, K. L.
T2 - Journal of Immunology
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2007///
VL - 179
IS - 11
SP - 7709
EP - 7719
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Cowley, S. C.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologies Research and Evaluation, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA.
N1 - Accession Number: 20073293447. Publication Type: Journal Article. Language: English. Number of References: 46 ref. Registry Number: 9008-11-1, 10102-43-9, 308079-78-9. Subject Subsets: Agricultural Biotechnology; Medical & Veterinary Entomology
N2 - During primary infection with intracellular bacteria, the membrane-associated form of TNF provides some TNF functions, but the relative contributions during memory responses are not well-characterized. In this study, we determined the role of T cell-derived secreted and membrane-bound TNF (memTNF) during adaptive immunity to Francisella tularensis live vaccine strain (LVS). Although transgenic mice expressing only the memTNF were more susceptible to primary LVS infection than wild-type (WT) mice, LVS-immune WT and memTNF mice both survived maximal lethal secondary Francisella challenge. Generation of CD44high memory T cells and clearance of bacteria were similar, although more IFN-γ and IL-12(p40) were produced by memTNF mice. To examine T cell function, we used an in vitro tissue coculture system that measures control of LVS intramacrophage growth by LVS-immune WT and memTNF-T cells. LVS-immune CD4+ and CD8+ T cells isolated from WT and memTNF mice exhibited comparable control of LVS growth in either normal or TNF-α knockout macrophages. Although the magnitude of CD4+ T cell-induced macrophage NO production clearly depended on TNF, control of LVS growth by both CD4+ and CD8+ T cells did not correlate with levels of nitrite. Importantly, intramacrophage LVS growth control by CD8+ T cells, but not CD4+ T cells, was almost entirely dependent on T cell-expressed TNF, and required stimulation through macrophage TNFRs. Collectively, these data demonstrate that T cell-expressed memTNF is necessary and sufficient for memory T cell responses to this intracellular pathogen, and is particularly important for intramacrophage control of bacterial growth by CD8+ T cells.
KW - animal models
KW - bacterial diseases
KW - CD4+ lymphocytes
KW - CD8+ lymphocytes
KW - cell mediated immunity
KW - experimental infections
KW - genetically engineered organisms
KW - immune response
KW - in vitro
KW - interferon
KW - interleukin 12
KW - laboratory animals
KW - macrophages
KW - nitric oxide
KW - strains
KW - transgenic animals
KW - tumour necrosis factor
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cachectin
KW - cachexin
KW - CD4+ cells
KW - CD8+ cells
KW - cellular immunity
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - T8 lymphocytes
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073293447&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: siobhan.cowley@fda.hhs.gov\karen.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antibodies to the A27 protein of vaccinia virus neutralize and protect against infection but represent a minor component of dryvax vaccine-induced immunity.
AU - He, Y.
AU - Manischewitz, J.
AU - Meseda, C. A.
AU - Merchlinsky, M.
AU - Vassell, R. A.
AU - Sirota, L.
AU - Berkower, I.
AU - Golding, H.
AU - Weiss, C. D.
T2 - Journal of Infectious Diseases
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007///
VL - 196
IS - 7
SP - 1026
EP - 1032
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - He, Y.: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20073233593. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 308067-57-4.
N2 - The smallpox vaccine Dryvax, which consists of replication-competent vaccinia virus, elicits antibodies that play a major role in protection. Several vaccinia proteins generate neutralizing antibodies, but their importance for protection is unknown. We investigated the potency of antibodies to the A27 protein of the mature virion in neutralization and protection experiments and the contributions of A27 antibodies to Dryvax-induced immunity. Using a recombinant A27 protein (rA27), we confirmed that A27 contains neutralizing determinants and that vaccinia immune globulin (VIG) derived from Dryvax recipients contains reactivity to A27. However, VIG neutralization was not significantly reduced when A27 antibodies were removed, and antibodies elicited by an rA27 enhanced the protection conferred by VIG in passive transfer experiments. These findings demonstrate that A27 antibodies do not represent the major fraction of neutralizing activity in VIG and suggest that immunity may be augmented by vaccines and immune globulins that include strong antibody responses to A27.
KW - animal models
KW - antibody formation
KW - experimental infection
KW - human diseases
KW - immune response
KW - immunization
KW - immunoglobulins
KW - laboratory animals
KW - neutralizing antibodies
KW - potency
KW - recombinant proteins
KW - smallpox
KW - vaccination
KW - vaccine development
KW - vaccines
KW - viral proteins
KW - virus neutralization
KW - mice
KW - rabbits
KW - Vaccinia virus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Leporidae
KW - Lagomorpha
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - experimental transmission
KW - gamma-globulins
KW - immune globulins
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073233593&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/JID/home.html
UR - email: carol.weiss@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling.
AU - Valerio, L. G., Jr.
AU - Arvidson, K. B.
AU - Chanderbhan, R. F.
AU - Contrera, J. F.
T2 - Toxicology and Applied Pharmacology
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2007///
VL - 222
IS - 1
SP - 1
EP - 16
CY - Orlando; USA
PB - Elsevier Inc
SN - 0041-008X
AD - Valerio, L. G., Jr.: Division of Biotechnology and GRAS Notice Review, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073161428. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Consistent with the U.S. Food and Drug Administration (FDA) Critical Path Initiative, predictive toxicology software programs employing quantitative structure-activity relationship (QSAR) models are currently under evaluation for regulatory risk assessment and scientific decision support for highly sensitive endpoints such as carcinogenicity, mutagenicity and reproductive toxicity. At the FDA's Center for Food Safety and Applied Nutrition's Office of Food Additive Safety and the Center for Drug Evaluation and Research's Informatics and Computational Safety Analysis Staff (ICSAS), the use of computational SAR tools for both qualitative and quantitative risk assessment applications are being developed and evaluated. One tool of current interest is MDL-QSAR predictive discriminant analysis modeling of rodent carcinogenicity, which has been previously evaluated for pharmaceutical applications by the FDA ICSAS. The study described in this paper aims to evaluate the utility of this software to estimate the carcinogenic potential of small, organic, naturally occurring chemicals found in the human diet. In addition, a group of 19 known synthetic dietary constituents that were positive in rodent carcinogenicity studies served as a control group. In the test group of naturally occurring chemicals, 101 were found to be suitable for predictive modeling using this software's discriminant analysis modeling approach. Predictions performed on these compounds were compared to published experimental evidence of each compound's carcinogenic potential. Experimental evidence included relevant toxicological studies such as rodent cancer bioassays, rodent anti-carcinogenicity studies, genotoxic studies, and the presence of chemical structural alerts. Statistical indices of predictive performance were calculated to assess the utility of the predictive modeling method. Results revealed good predictive performance using this software's rodent carcinogenicity module of over 1200 chemicals, comprised primarily of pharmaceutical, industrial and some natural products developed under an FDA-MDL cooperative research and development agreement (CRADA). The predictive performance for this group of dietary natural products and the control group was 97% sensitivity and 80% concordance. Specificity was marginal at 53%. This study finds that the in silico QSAR analysis employing this software's rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity. It is the first study to demonstrate successful QSAR predictive modeling of naturally occurring carcinogens found in the human diet using an external validation test. Further test validation of this software and expansion of the training data set for dietary chemicals will help to support the future use of such QSAR methods for screening and prioritizing the risk of dietary chemicals when actual animal data are inadequate, equivocal, or absent.
KW - carcinogens
KW - chemical structure
KW - chemicals
KW - food contamination
KW - food safety
KW - organic compounds
KW - structure activity relationships
KW - food contaminants
KW - organic chemicals
KW - quantitative structure activity relationship
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161428&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4NBBYMT-2&_user=10&_coverDate=07%2F01%2F2007&_rdoc=2&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%237159%232007%23997779998%23661604%23FLA%23display%23Volume)&_cdi=7159&_sort=d&_docanchor=&view=c&_ct=15&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=de18d465029fc823e6ffbe8163043da7
UR - email: luis.valerio@FDA.HHS.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Particle size-dependent radical generation from wildland fire smoke.
AU - Leonard, S. S.
AU - Castranova, V.
AU - Chen, B. T.
AU - Schwegler-Berry, D.
AU - Hoover, M.
AU - Piacitelli, C.
AU - Gaughan, D. M.
JO - Toxicology
JF - Toxicology
Y1 - 2007///
VL - 236
IS - 1/2
SP - 103
EP - 113
CY - Shannon; Irish Republic
PB - Elsevier Ireland
SN - 0300-483X
AD - Leonard, S. S.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 20073202392. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Firefighting, along with construction, mining and agriculture, ranks among the most dangerous occupations. In addition, the work environment of firefighters is unlike that of any other occupation, not only because of the obvious physical hazards but also due to the respiratory and systemic health hazards of smoke inhalation resulting from combustion. A significant amount of research has been devoted to studying municipal firefighters; however, these studies may not be useful in wildland firefighter exposures, because the two work environments are so different. Not only are wildland firefighters exposed to different combustion products, but their exposure profiles are different. The combustion products wildland firefighters are exposed to can vary greatly in characteristics due to the type and amount of material being burned, soil conditions, temperature and exposure time. Smoke inhalation is one of the greatest concerns for firefighter health and it has been shown that the smoke consists of a large number of particles. These smoke particles contain intermediates of hydrogen, carbon and oxygen free radicals, which may pose a potential health risk. Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. Samples were collected in discrete aerodynamic particle sizes from a wildfire in Alaska, preserved and then shipped to our laboratory for analysis. Electron spin resonance was used to measure carbon-centered as well as hydroxyl radicals produced by a Fenton-like reaction with wildfire smoke. Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. Results demonstrate that coarse size-range particles contained more carbon radicals per unit mass than the ultrafine particles; however, the ultrafine particles generated more .OH radicals in the acellular Fenton-like reaction. The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. All particle sizes showed the ability to cause DNA damage. These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size.
KW - cell membranes
KW - fire fighters
KW - hazards
KW - health hazards
KW - lipid peroxidation
KW - monocytes
KW - occupations
KW - reactive oxygen species
KW - soil
KW - temperature
KW - Alaska
KW - USA
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - firemen
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073202392&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCN-4NJWNYK-2&_user=10&_coverDate=07%2F01%2F2007&_rdoc=12&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235175%232007%23997639998%23659206%23FLA%23display%23Volume)&_cdi=5175&_sort=d&_docanchor=&view=c&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c956eaaf60c4177665bb21525d7feeee
UR - email: SEL5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samples.
AU - Hsia, C. C.
AU - Chizhikov, V. E.
AU - Yang, A. X.
AU - Selvapandiyan, A.
AU - Hewlett, I.
AU - Duncan, R.
AU - Puri, R. K.
AU - Nakhasi, H. L.
AU - Kaplan, G. G.
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
Y1 - 2007///
VL - 356
IS - 4
SP - 1017
EP - 1023
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0006-291X
AD - Hsia, C. C.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20073145135. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus type-1 (HIV-1) are transfusion-transmitted human pathogens that have a major impact on blood safety and public health worldwide. We developed a microarray multiplex assay for the simultaneous detection and discrimination of these three viruses. The microarray consists of 16 oligonucleotide probes, immobilized on a silylated glass slide. Amplicons from multiplex PCR were labeled with Cy-5 and hybridized to the microarray. The assay detected 1 International Unit (IU), 10 IU, 20 IU of HBV, HCV, and HIV-1, respectively, in a single multiplex reaction. The assay also detected and discriminated the presence of two or three of these viruses in a single sample. Our data represent a proof-of-concept for the possible use of highly sensitive multiplex microarray assay to screen and confirm the presence of these viruses in blood donors and patients.
KW - assays
KW - blood
KW - blood transfusion
KW - detection
KW - diagnosis
KW - hepatitis B
KW - hepatitis C
KW - HIV-1 infections
KW - screening
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Human immunodeficiency virus 1
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Human immunodeficiency virus type 1
KW - microarrays
KW - screening tests
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073145135&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0006291X
UR - email: chuchieh.hsia@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mutation analysis of the fusion domain region of St. Louis encephalitis virus envelope protein.
AU - Trainor, N. B.
AU - Crill, W. D.
AU - Roberson, J. A.
AU - Chang, G. J. J.
JO - Virology
JF - Virology
Y1 - 2007///
VL - 360
IS - 2
SP - 398
EP - 406
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Trainor, N. B.: Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20073271595. Publication Type: Journal Article. Language: English. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - The immune response to flavivirus infections produces both species-specific and flavivirus cross-reactive antibodies. The presence of cross-reactive antibodies complicates serodiagnosis of flavivirus infections, especially secondary infections caused by a heterologous virus. A successful public health response to the growing global threat posed by flaviviruses necessitates the development of virus-specific diagnostic antigens. The flavivirus envelope (E) glycoprotein is the principle antigen stimulating protective immunity during infection. Using recombinant St. Louis encephalitis virus-like particles (VLPs), we have identified amino acid residues involved in flavivirus cross-reactive epitope determinants. Most significant among the residues studied are three highly conserved amino acids in the fusion peptide: Gly104, Gly106, and Leu107. Substitutions of these residues dramatically influenced VLP secretion and cross-reactive monoclonal antibody reactivity. These results provide critical insight into the antigenic structure of the flaviviral E protein and toward development of species-specific diagnostic antigens that should improve both flavivirus diagnosis and estimates of disease burden.
KW - amino acids
KW - antibodies
KW - antigens
KW - cross reaction
KW - diagnosis
KW - diagnostic techniques
KW - envelope glycoproteins
KW - envelope proteins
KW - human diseases
KW - immune response
KW - mutational analysis
KW - mutations
KW - St Louis encephalitis
KW - viral diseases
KW - viral proteins
KW - man
KW - St Louis encephalitis virus
KW - St. Louis encephalitis virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - antigenicity
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073271595&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXR-4MH8B7Y-1&_user=10&_coverDate=04%2F10%2F2007&_rdoc=16&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%237165%232007%23996399997%23647400%23FLA%23display%23Volume)&_cdi=7165&_sort=d&_docanchor=&_ct=24&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a61b813feeda79f0da808fea992fb2d3
UR - email: wcrill@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recent studies on selected botanical dietary supplement ingredients.
AU - Rader, J. I.
AU - Delmonte, P.
AU - Trucksess, M. W.
A2 - Sharpless, K. E.
A2 - Ulberth, F.
T3 - Special Issue: Food and dietary supplements.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2007///
VL - 389
IS - 1
SP - 27
EP - 35
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 1618-2642
AD - Rader, J. I.: Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083042070. Publication Type: Journal Article. Note: Special Issue: Food and dietary supplements. Language: English. Subject Subsets: Plant Pathology; Human Nutrition; Postharvest Research; Medical & Veterinary Mycology
N2 - The market for botanical dietary supplements in the US has grown rapidly during the last 15 years. Use of newly introduced botanical ingredients has often outpaced an adequate scientific understanding of the ingredients themselves. This may lead to problems, including misidentification, mislabeling, adulteration, and toxicity related to the intended ingredient or one substituted for it. This article reviews recent work with several botanical ingredients (Ephedra, Citrus species, Hoodia gordonii, Teucrium, isoflavones) that illustrates the complexity of the current situation and approaches that contribute to ensuring the quality of botanical ingredients. Recent work with contamination of botanical products by mycotoxins is also reviewed. The need for tools for botanical authentication and methods for reproducible extraction of bioactive constituents is critical. Such tools, and improved analytical techniques for identifying potentially bioactive constituents in fresh plant material and in concentrated extracts and for detection of hazardous contaminants, are expected to improve the overall quality and safety of botanical dietary supplement ingredients.
KW - chemical composition
KW - food contamination
KW - food quality
KW - food safety
KW - food supplements
KW - isoflavones
KW - mycotoxins
KW - reviews
KW - Apocynaceae
KW - Citrus
KW - Ephedra
KW - Teucrium
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rutaceae
KW - Sapindales
KW - Ephedraceae
KW - Gnetopsida
KW - gymnosperms
KW - Lamiaceae
KW - Lamiales
KW - food contaminants
KW - fungal toxins
KW - Hoodia gordonii
KW - Rutales
KW - Crop Produce (QQ050)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083042070&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/g447836u14661004/?p=5ae0686080a343ba89db24e911dcb888&pi=5
UR - email: Jeanne.Rader@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measuring vitamins and minerals in dietary supplements for nutrition studies in the USA.
AU - Dwyer, J. T.
AU - Holden, J.
AU - Andrews, K.
AU - Roseland, J.
AU - Zhao, C. W.
AU - Schweitzer, A.
AU - Perry, C. R.
AU - Harnly, J.
AU - Wolf, W. R.
AU - Picciano, M. F.
AU - Fisher, K. D.
AU - Saldanha, L. G.
AU - Yetley, E. A.
AU - Betz, J. M.
AU - Coates, P. M.
AU - Milner, J. A.
AU - Whitted, J.
AU - Burt, V.
AU - Radimer, K.
AU - Wilger, J.
AU - Sharpless, K. E.
AU - Hardy, C. J.
A2 - Sharpless, K. E.
A2 - Ulberth, F.
T3 - Special Issue: Food and dietary supplements.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2007///
VL - 389
IS - 1
SP - 37
EP - 46
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 1618-2642
AD - Dwyer, J. T.: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083042071. Publication Type: Journal Article. Note: Special Issue: Food and dietary supplements. Language: English. Subject Subsets: Human Nutrition
N2 - This article illustrates the importance of having analytical data on the vitamin and mineral contents of dietary supplements in nutrition studies, and describes efforts to develop an analytically validated dietary supplement ingredient database (DSID) by a consortium of federal agencies in the USA. Preliminary studies of multivitamin mineral supplements marketed in the USA that were analyzed as candidates for the DSID are summarized. Challenges are summarized, possible future directions are outlined, and some related programs at the Office of Dietary Supplements, National Institutes of Health are described. The DSID should be helpful to researchers in assessing relationships between intakes of vitamins and minerals and health outcomes.
KW - chemical composition
KW - food supplements
KW - mineral content
KW - vitamin content
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Other Produce (QQ070)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083042071&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/h831tq8131547p74/?p=78d780b2479d48a981109852b5a566ab&pi=6
UR - email: dwyerj1@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of gas chromatographic methods for the determination of trans fat.
AU - Delmonte, P.
AU - Rader, J. I.
A2 - Sharpless, K. E.
A2 - Ulberth, F.
T3 - Special Issue: Food and dietary supplements.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2007///
VL - 389
IS - 1
SP - 77
EP - 85
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 1618-2642
AD - Delmonte, P.: US Food and Drug Administration, HFS-717, Room 1E006, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20083042074. Publication Type: Journal Article. Note: Special Issue: Food and dietary supplements. Language: English. Subject Subsets: Human Nutrition; Public Health
N2 - Consumption of trans fat has been associated with increased risk of coronary heart disease. For nutrition labeling purposes, the US Food and Drug Administration (FDA) defines trans fat as the sum of all the fatty acids with at least one nonconjugated double bond in the trans configuration. The FDA regulation states that label declarations of trans fat are not required for products that contain less than 0.5 g of trans fat per serving if no claims are made about fat, fatty acids or cholesterol. While attenuated total reflection Fourier-transformed infrared spectroscopy (ATR-FT-IR) provides reproducible measurements for samples containing more than 5% trans fat, methods based on gas chromatography (GC) are needed to measure lower trans fat levels. Trans fat quantitation by GC has recently been updated by considering more fatty acids, focusing more attention on fatty acids present in low amounts, and by using 100-m high-polarity capillary columns for optimal separation. The consistently high interlaboratory relative standard deviations (RSD, e.g., 21% at 1% trans fatty acids (TFA), 60% at 0.17% TFA), and intralaboratory RSD values (e.g., 10% at 1% TFA, 16% at 0.17% TFA) for trans fat at 1% or less of total fat reported in the collaborative study data for American Oil Chemists Society Official Method Ce 1h-05 suggest the need to carefully define the parameters associated with GC analysis of fatty acids.
KW - analytical methods
KW - chemical composition
KW - gas chromatography
KW - heart diseases
KW - human diseases
KW - trans fatty acids
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - coronary diseases
KW - Food Composition and Quality (QQ500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083042074&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/05046334h4472k30/?p=78d780b2479d48a981109852b5a566ab&pi=9
UR - email: pierluigi.delmonte@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of total trans fats and oils by infrared spectroscopy for regulatory compliance.
AU - Mossoba, M. M.
AU - Milosevic, V.
AU - Milosevic, M.
AU - Kramer, J. K. G.
AU - Azizian, H.
A2 - Sharpless, K. E.
A2 - Ulberth, F.
T3 - Special Issue: Food and dietary supplements.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2007///
VL - 389
IS - 1
SP - 87
EP - 92
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 1618-2642
AD - Mossoba, M. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-717, Room BE-012, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083042075. Publication Type: Journal Article. Note: Special Issue: Food and dietary supplements. Language: English. Subject Subsets: Human Nutrition
N2 - The mandatory requirement in many countries to declare the amount of trans fat present in food products and dietary supplements has led to a need for sensitive and accurate methodologies for the rapid quantitation of total trans fats and oils. Capillary gas chromatography (GC) and infrared spectroscopy (IR) are the two methods most commonly used to identify and quantify trans fatty acids for food labeling purposes (see the article by Delmonte and Rader in this ABC issue for a detailed presentation of GC methodology). The present article provides a comprehensive review of the IR technique and the current attenuated total reflection (ATR) Fourier-transform (FT) IR methodologies for the rapid determination of total trans fats and oils. This review also addresses potential sources of interferences and inaccuracies in FTIR determinations, particularly those done at low trans levels. Recent observations have shown that the presence of saturated fats caused interferences in the FTIR spectra observed for trans triacylglycerols. The recognition and resolution of previously unresolved quantitative issues improved the accuracy and sensitivity of the FTIR methodology. Once validated, it is anticipated that the new negative second-derivative ATR-FTIR procedure will make IR spectroscopy more suitable than ever, and a rapid alternative and/or complementary method to GC, for the rapid determination of total trans fats for regulatory compliance.
KW - analytical methods
KW - chemical composition
KW - detection
KW - infrared spectroscopy
KW - oils
KW - rapid methods
KW - reviews
KW - saturated fats
KW - trans fatty acids
KW - triacylglycerols
KW - analytical techniques
KW - triglycerides
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083042075&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/b81769652238wrjn/?p=791b04c9364e444fa2af05728cc1ad11&pi=10
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of food for toxic elements.
AU - Capar, S. G.
AU - Mindak, W. R.
AU - Cheng, J.
A2 - Sharpless, K. E.
A2 - Ulberth, F.
T3 - Special Issue: Food and dietary supplements.
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
Y1 - 2007///
VL - 389
IS - 1
SP - 159
EP - 169
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 1618-2642
AD - Capar, S. G.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W. Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083042081. Publication Type: Journal Article. Note: Special Issue: Food and dietary supplements. Language: English. Registry Number: 7429-90-5, 7440-38-2, 7440-43-9, 7439-92-1, 7439-97-6, 7440-31-5. Subject Subsets: Human Nutrition
N2 - The levels of the toxic elements Al, As, Cd, Hg, Pb and Sn are routinely monitored in food to protect the consumer. Increasingly, the chemical forms of As and Hg are also monitored. Analyses are performed to enforce regulatory standards and to accumulate background levels for assessing long-term exposure. The analytical procedures used for these activities evolve as requirements to determine lower levels arise and as both the types and sheer number of different foods that need to be analyzed increase. This review highlights recent work addressing improvements in the analysis of toxic elements in food. The topics covered include contamination control, analytical sample treatment and the common analytical techniques used for food analysis.
KW - aluminium
KW - analytical methods
KW - arsenic
KW - cadmium
KW - chemical analysis
KW - food contamination
KW - food safety
KW - lead
KW - mercury
KW - reviews
KW - tin
KW - toxic substances
KW - aluminum
KW - analytical techniques
KW - food contaminants
KW - poisons
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083042081&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/w111387l56773046/?p=791b04c9364e444fa2af05728cc1ad11&pi=16
UR - email: stephen.capar@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ultra-trace determination of beryllium in occupational hygiene samples by ammonium bifluoride extraction and fluorescence detection using hydroxybenzoquinoline sulfonate.
AU - Ashley, K.
AU - Agrawal, A.
AU - Cronin, J.
AU - Tonazzi, J.
AU - McCleskey, T. M.
AU - Burrell, A. K.
AU - Ehler, D. S.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2007///
VL - 584
IS - 2
SP - 281
EP - 286
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Ashley, K.: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, M.S. R-7, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20083049677. Publication Type: Journal Article. Language: English. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - A highly sensitive molecular fluorescence method for measuring ultra-trace levels of beryllium has been previously described. The method entails extraction of beryllium workplace samples by 1% ammonium bifluoride (NH4HF2, aqueous), followed by fluorescence detection using hydroxybenzoquinoline sulfonate (HBQS). In this work, modification of the existing procedure resulted in a significant improvement in detection power, thereby enabling ultra-trace determination of beryllium in air filter and surface wipe samples. Such low detection limits may be necessary in view of expected decreases in applicable occupational exposure limits (OELs) for beryllium. Attributes of the modified NH4HF2 extraction/HBQS fluorescence method include method detection limits (MDLs) of <0.8 ng to ~2 ng Be per sample (depending on the fluorometer used), quantitative recoveries from beryllium oxide, a dynamic range of several orders of magnitude, and freedom from interferences. Other key advantages of the technique are field portability, relatively low cost, and high sample throughput. The method performance compares favorably with that of inductively coupled plasma-mass spectrometry (ICP-MS).
KW - air filters
KW - beryllium
KW - detection
KW - extraction
KW - methodology
KW - monitoring
KW - work places
KW - ammonium bifluoride
KW - hydroxybenzoquinoline sulfonate
KW - methods
KW - surveillance systems
KW - Occupational Health and Safety (VV900)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083049677&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4MGM2S1-6&_user=10&_coverDate=02%2F19%2F2007&_rdoc=9&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235216%232007%23994159997%23643129%23FLA%23display%23Volume)&_cdi=5216&_sort=d&_docanchor=&_ct=34&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9ac9b87379757468339d8949f18a3339
UR - email: kashley@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry.
AU - Karbiwnyk, C. M.
AU - Carr, L. E.
AU - Turnipseed, S. B.
AU - Andersen, W. C.
AU - Miller, K. E.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2007///
VL - 596
IS - 2
SP - 257
EP - 263
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Karbiwnyk, C. M.: Animal Drugs Research Center, Food and Drug Administration, Denver, Colorado, USA.
N1 - Accession Number: 20073219642. Publication Type: Journal Article. Language: English. Registry Number: 14698-29-4, 389-08-2. Subject Subsets: Human Nutrition
N2 - The quinolones, oxolinic acid (OXO), flumequine (FLU), and nalidixic acid (NAL), are antibacterial drugs effective against Gram-negative bacteria. Quinolones are used in both human and veterinary medicine, but are currently not approved by the U.S. Food and Drug Administration for use in food fish. A liquid chromatography-fluorescence (LC-FL) method was developed to determine OXO, FLU, and NAL residues in shrimp. An additional liquid chromatography-mass spectrometry (LC-MSn) method was created to confirm these residues using the same sample extract. Samples were prepared with a simple ethyl acetate extraction followed by solvent exchange into 0.2% formic acid and cleaned-up with hexane. Reverse phase chromatography was used to separate the three compounds in both procedures. For the LC-FL determinative method, fluorescence emission was monitored at 369 nm with excitation at 327 nm. With electrospray ionization, the three most abundant ions from the MS3 product ion spectrum were used to identify OXO, FLU, and NAL in the confirmation procedure. Shrimp samples fortified at levels ranging from 7.5 to 100 ng g-1 were used to validate both methods.
KW - analytical methods
KW - antibacterial agents
KW - drug residues
KW - fluorescence
KW - liquid chromatography
KW - mass spectrometry
KW - nalidixic acid
KW - oxolinic acid
KW - quinolones
KW - shrimps
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - analytical techniques
KW - flumequine
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Toxicology and Poisoning (Wild Animals) (YY900) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073219642&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4P06CJT-4&_user=10&_coverDate=07%2F23%2F2007&_rdoc=11&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235216%232007%23994039997%23662504%23FLA%23display%23Volume)&_cdi=5216&_sort=d&_docanchor=&view=c&_ct=22&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=34bc7293f90db57dc3a0564773bc2869
UR - email: christine.karbiwnyk@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New approaches to assessing the effects of mutagenic agents on the integrity of the human genome.
AU - Elespuru, R. K.
AU - Sankaranarayanan, K.
A2 - Mohrenweiser, H.
A2 - Batzer, M.
A2 - Felton, J.
A2 - Galloway, S.
T3 - Special issue: Dedicated in memory of Dr Tony Carrano.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2007///
VL - 616
IS - 1/2
SP - 83
EP - 89
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0027-5107
AD - Elespuru, R. K.: Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, Netherlands.
N1 - Accession Number: 20073048192. Publication Type: Journal Article. Note: Special issue: Dedicated in memory of Dr Tony Carrano. Language: English. Number of References: 76 ref. Subject Subsets: Public Health
N2 - Heritable genetic alterations, although individually rare, have a substantial collective health impact. Approximately 20% of these are new mutations of unknown cause. Assessment of the effect of exposures to DNA damaging agents, i.e. mutagenic chemicals and radiations, on the integrity of the human genome and on the occurrence of genetic disease remains a daunting challenge. Recent insights may explain why previous examination of human exposures to ionizing radiation, as in Hiroshima and Nagasaki, failed to reveal heritable genetic effects. New opportunities to assess the heritable genetic damaging effects of environmental mutagens are afforded by: (1) integration of knowledge on the molecular nature of genetic disorders and the molecular effects of mutagens; (2) the development of more practical assays for germline mutagenesis; (3) the likely use of population-based genetic screening in personalized medicine.
KW - genetic disorders
KW - genetics
KW - genomes
KW - heritability
KW - ionizing radiation
KW - mutagens
KW - mutational analysis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - genetic defects
KW - hereditary defects
KW - heritable characters
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073048192&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00275107
UR - email: Rosalie.Elespuru@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Rapid quantitative and qualitative confirmatory method for the determination of monofluoroacetic acid in foods by liquid chromatography-mass spectrometry.
AU - Noonan, G. O.
AU - Begley, T. H.
AU - Diachenko, G. W.
T2 - Journal of Chromatography, A
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2007///
VL - 1139
IS - 2
SP - 271
EP - 278
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Noonan, G. O.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073161117. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A rapid quantitative method and a qualitative confirmatory method for the determination of monofluoroacetic acid (MFA) in complex food matrices are presented. The quantitative method utilizes a water extraction, solid phase extraction clean-up and liquid chromatography-mass spectrometry (LC-MS) for determination of MFA. This method showed a high degree of specificity, detecting MFA in all of the spiked samples, while none of the unfortified samples tested positive for MFA. Spike recoveries were high in all matrices analyzed, varying from 85 to 110%, and comparable at low (2 mg/L) and high (20 mg/L) spiking levels. Repeatability tests at the low spiking levels yielded RSDs of less than 5% for all matrices analyzed. The qualitative confirmatory method developed is conceptually different from the quantitative method, ensuring that both methods would not be subject to the same interferences. The method uses the formation of the hydrazide of MFA through derivatization with 2-nitrophenylhydrazine. This derivatization is well established for the determination of carboxylic acids, but this is the first application to the determination of MFA. The derivatization yield was matrix dependent, however the limit of detection (LOD) (0.8 µg/L) was sufficient to confirm the presence of MFA in all spiked matrices. Repeatability tests at the low spiking levels yielded RSDs of approximately 7% for all matrices analyzed.
KW - analytical methods
KW - determination
KW - food contamination
KW - liquid chromatography
KW - mass spectrometry
KW - analytical techniques
KW - food contaminants
KW - monofluoroacetic acid
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073161117&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4MG6P98-3&_user=10&_coverDate=01%2F19%2F2007&_rdoc=17&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235248%232007%23988609997%23639771%23FLA%23display%23Volume)&_cdi=5248&_sort=d&_docanchor=&view=c&_ct=21&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a33b2909534bda07353a72201944098f
UR - email: Gregory.noonan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Rapid methods for the detection of foodborne pathogens: Current and next-generation technologies.
AU - Feng, P.
A2 - Doyle, M. P.
A2 - Beuchat, L. R.
T2 - Food microbiology: fundamentals and frontiers
Y1 - 2007///
CY - Washington; USA
PB - ASM Press
SN - 9781555814076\1555814077
AD - Feng, P.: Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073099197. Publication Type: Book chapter. Language: English. Subject Subsets: Human Nutrition
N2 - Technology has enabled considerable progress in the field of rapid diagnostics, especially where pathogenic microorganisms are concerned. This is particular true of assays for the detection of foodborne pathogens, for which time is a vital component. This chapter covers developments in technology that have led to the rapid methods in use today and includes descriptions of assays that have been developed specifically for the identification of bacterial toxins. Of the next-generation technologies, the author highlights rtPCR, immonosensors and biosensors and the use of DNA micro arrays for detecting, identifying and characterizing pathogens, giving specific examples of their application. Finally, the author details some advantages and limitations to the application of rapid methods and points to areas that would benefit from further development.
KW - analytical methods
KW - bacterial toxins
KW - biosensors
KW - detection
KW - food
KW - food microbiology
KW - immunoassay
KW - pathogens
KW - rapid methods
KW - reverse transcriptase PCR
KW - techniques
KW - analytical techniques
KW - foodborne microbes
KW - microbial techniques
KW - reverse transcriptase polymerase chain reaction
KW - RT-PCR
KW - rtPCR
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Biosensors and Biological Nanotechnology (WW900) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099197&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Shigella species.
AU - Lampel, K. A.
AU - Maurelli, A. T.
A2 - Doyle, M. P.
A2 - Beuchat, L. R.
T2 - Food microbiology: fundamentals and frontiers
Y1 - 2007///
CY - Washington; USA
PB - ASM Press
SN - 9781555814076\1555814077
AD - Lampel, K. A.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073097439. Publication Type: Book chapter. Language: English. Subject Subsets: Human Nutrition; Tropical Diseases; Dairy Science
N2 - This chapter covers the microbiology, transmission and pathogenesis of Shigella species. The authors contend that shigellosis is a neglected area of study on a global scale and that more effort should be made to alert food microbiologists to diseases caused by Shigella species, including Shigella dysenteriae, S. flexneri and S. sonnei. In particular, the authors concentrate on the occurrence, survival and transmission of these bacteria in foods, citing specific examples of major foodborne outbreaks from a wide variety of foods. The characteristics of the disease: its clinical presentation, infectious dose, complications, treatment and prevention are described. The authors conclude with a review of the virulence of the organism and how it regulates expression of its virulence genes in response to growth temperature.
KW - clinical aspects
KW - disease prevention
KW - disease transmission
KW - drug therapy
KW - epidemiology
KW - food contamination
KW - food microbiology
KW - foodborne diseases
KW - gene expression
KW - growth
KW - infant formulae
KW - outbreaks
KW - pathogenesis
KW - shigellosis
KW - virulence
KW - Shigella
KW - Shigella dysenteriae
KW - Shigella flexneri
KW - Shigella sonnei
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Shigella
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - food contaminants
KW - foodborne microbes
KW - infant formula
KW - infant formulas
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073097439&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Progress and microbiological modeling and risk assessment.
AU - Whiting, R. C.
AU - Buchanan, R. L.
A2 - Doyle, M. P.
A2 - Beuchat, L. R.
T2 - Food microbiology: fundamentals and frontiers
Y1 - 2007///
CY - Washington; USA
PB - ASM Press
SN - 9781555814076\1555814077
AD - Whiting, R. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073099199. Publication Type: Book chapter. Language: English. Subject Subsets: Human Nutrition
N2 - Modelling techniques are commonly used to describe experimental results and to make quantitive predictions. The authors begin with the argument that although the parameters included in models derived from bacterial growth in broth media yield useful data, they must still be validated in foodstuffs for them to be of use in food microbiology, especially in risk assessments and the design of HACCP-based food safety programs. This chapter discusses the use of modelling techniques in food safety and describes some of the characteristics of foodstuffs that can affect predictions of the growth of foodborne pathogens, including food structure, water activity, strain variation and competition between microbial strains. The authors conclude by explaining risk assessment: how it can be used to make decisions about food safety, how to manage risk analysis and perform risk assessments and what factors contribute to variation and uncertainty in risk assessment models.
KW - food safety
KW - growth models
KW - HACCP
KW - hazards
KW - risk analysis
KW - risk assessment
KW - food spoilage bacteria
KW - foodborne microbes
KW - hazard analysis critical control points
KW - microbial growth
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073099199&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Achieving and sustaining Universal Salt Iodization (USI): doing it well through regulation and enforcement. Lessons learned from USI in Nigeria.
AU - Akunyili, D. N.
JO - SCN News
JF - SCN News
Y1 - 2007///
IS - 35
SP - 43
EP - 47
CY - Geneva; Switzerland
PB - UN/AAC Subcommittee on Nutrition
SN - 1564-3743
AD - Akunyili, D. N.: National Agency For Food and Drug Administration and Control (NAFDAC), Lagos, Nigeria.
N1 - Accession Number: 20083039845. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Registry Number: 7553-56-2. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology; Rural Development; Tropical Diseases
N2 - Prior to 1993, Iodine Deficiency Disorders (IDD) were recognized as a public health problem in Nigeria. Following a series of international summits, meetings and resolutions, Nigeria initiated its USI program, deriving momentum from three key success factors; political commitment by government, commitment by salt industry and effective multi-sectoral partnership. In 1993, Universal Salt Iodization (USI) law was enacted and made mandatory in Nigeria. Within a period of five years access to adequately iodized salt had grown from a zero base in 1993 to reach an impressive level of 98% of Nigeria's households by 1998. This has been further sustained through aggressive enforcement by government and compliance by the salt industry, and Nigeria currently ranks high on global and regional report cards. In 2005, the goitre rate was 6.2%, down from 20% in 1993. Median Urinary Iodine excretion rate has consistently been over 130 µg/dl since 1999. Improvements in urinary iodine excretion and goitre rates have been substantive. In addition, the 10 point criteria for USI certification have consistently been met, which paved way for Nigeria's certification as the first country in Africa to achieve USI compliance in 2005 by the Network for Sustained Elimination of Iodine Deficiency. This paper summarizes Nigeria USI programme strategies and actions in hopes of assisting countries that have yet to achieve USI.
KW - food industry
KW - fortification
KW - goitre
KW - human diseases
KW - iodine
KW - iodized salt
KW - legislation
KW - nutrition programmes
KW - policy
KW - trace element deficiencies
KW - Nigeria
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - West Africa
KW - Africa South of Sahara
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - goiter
KW - nutrition programs
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Policy and Planning (EE120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083039845&site=ehost-live&scope=site
UR - email: dnakunyili@yahoo.com
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Indicator microorganisms and microbiological criteria.
AU - Pierson, M. D.
AU - Zink, D. L.
AU - Smoot, L. M.
A2 - Doyle, M. P.
A2 - Beuchat, L. R.
T2 - Food microbiology: fundamentals and frontiers
Y1 - 2007///
IS - Ed.3
CY - Washington; USA
PB - ASM Press
SN - 9781555814076\1555814077
AD - Pierson, M. D.: Dept. of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.\U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College ark, MD 20740, USA.
N1 - Accession Number: 20073097426. Publication Type: Book chapter. Language: English. Subject Subsets: Human Nutrition
N2 - The microbiological criteria on which HACCP-based food quality assurance programs are based are described. The authors provide an overview of the purpose of microbiological criteria in this context and discuss the definitions and establishment of such criteria used in the food industry. Sampling plans and the limits above which action should be taken are described. After a discussion of the indicators used for measuring microbiological quality, including indicator microorganisms, metabolic products and toxins, the authors conclude with a discussion of the practical application of microbial safety programs and recommend the further development of quantitative risk assessment techniques.
KW - food contamination
KW - food processing
KW - food processing quality
KW - food quality
KW - food safety
KW - HACCP
KW - microbial contamination
KW - microbiological techniques
KW - risk analysis
KW - risk reduction
KW - food chain
KW - food contaminants
KW - food sampling
KW - foodborne microbes
KW - hazard analysis critical control points
KW - indicator microorganisms
KW - quality assurance programs
KW - quality for food processing
KW - Food Composition and Quality (QQ500)
KW - Human Health and the Environment (VV500)
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073097426&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Toxicology and risk assessment of chemical migrants from food contact materials.
AU - Arvidson, K. B.
AU - Cheeseman, M. A.
AU - McDougal, A. J.
A2 - Barnes, K. A.
A2 - Sinclair, C. R.
A2 - Watson, D. H.
T2 - Chemical migration and food contact materials
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2007///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 9781845690298\184569029X
AD - Arvidson, K. B.: Office of Food Additive Safety HFS-275, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20073102916. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - A background on how the US Food and Drug Administration (FDA) performs toxicological evaluations and safety assessments for food additives is presented, including discussions on the regulatory framework for food contact materials in USA. Risk and safety assessments of food additive constituents that may have carcinogenic properties are discussed as well.
KW - carcinogens
KW - diet
KW - food additives
KW - food contamination
KW - food safety
KW - neoplasms
KW - packaging materials
KW - regulations
KW - risk assessment
KW - toxicology
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - food contaminants
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Storage and Preservation (QQ110)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073102916&site=ehost-live&scope=site
UR - email: kirk.arvidson@fda.hhs.gov\mitchell.cheeseman@fda.hhs.gov\andrew.mcdougal@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation of food contact materials in the USA.
AU - Twaroski, M. L.
AU - Batarseh, L. I.
AU - Bailey, A. B.
A2 - Barnes, K. A.
A2 - Sinclair, C. R.
A2 - Watson, D. H.
T2 - Chemical migration and food contact materials
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2007///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 9781845690298\184569029X
AD - Twaroski, M. L.: Office of Food Additive Safety HFS-275, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073102917. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Number of References: 11 ref.
N2 - Discussions on the regulatory processes in the USA with regard to indirect food additives or components of food contact articles are presented, including discussions on the authority given to the US Food and Drug Administration by previously enacted laws to assess the safety of food contact article components. The regulatory approaches for the legal approval of the use and technical review of food contact notification are discussed as well.
KW - food additives
KW - food contamination
KW - food safety
KW - law
KW - packaging materials
KW - regulations
KW - risk assessment
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - legal aspects
KW - legal principles
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Storage and Preservation (QQ110)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073102917&site=ehost-live&scope=site
UR - email: michelle.twaroski@fda.hhs.gov\Allan.Bailey@fda.hhs.gov\layla.batarshe@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Foodborne diseases.
AU - Simjee, S.
A2 - Simjee, S.
T2 - Foodborne diseases
T3 - Infectious Disease
Y1 - 2007///
CY - Totowa; USA
PB - Humana Press
SN - 9781588295187
AD - Simjee, S.: United States Food and Drug Administration, Laurel, Maryland, USA.
N1 - Accession Number: 20093081267. Publication Type: Book. Note: Infectious Disease Language: English. Number of References: many ref. Subject Subsets: Public Health; Protozoology; Human Nutrition
N2 - This book presents a broad overview of the microbial pathogens and toxins associated with foodborne illness while discussing pathogenicity, clinical epidemiology, diagnosis, and treatment. The chapters in this volume cover a wide variety of bacterial pathogens, viruses, protozoans and parasites, as well as microbial toxins, and also address alternatives to antibiotics, risk assessment, irradiation and other sanitation procedures, and molecular techniques for detecting foodborne pathogens. Additionally, pathogen control strategies are discussed. Covering essential foodborne pathogens, assessment and treatment, Foodborne Diseases is an essential reference for infectious disease specialists, microbiologists, and industrial and research-based scientists in food safety.
KW - antibiotics
KW - detection
KW - diagnosis
KW - epidemiology
KW - food hygiene
KW - foodborne diseases
KW - human diseases
KW - irradiation
KW - medical treatment
KW - parasites
KW - pathogenicity
KW - risk assessment
KW - sanitation
KW - techniques
KW - toxins
KW - Bacteria
KW - man
KW - Protozoa
KW - viruses
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - invertebrates
KW - bacterium
KW - Other Control Measures (HH700)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093081267&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Evaluating fidelity and effectiveness of interventions.
AU - Berger, L. R.
AU - Grossman, D. C.
A2 - Doll, L. S.
A2 - Bonzo, S. E.
A2 - Mercy, J. A.
A2 - Sleet, D. A.
T2 - Handbook of injury and violence prevention
Y1 - 2007///
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0387259244\9780387259246
AD - Berger, L. R.: Indian Health Service Injury Prevention Program, Albuquerque, NM 87106, USA.
N1 - Accession Number: 20083203793. Publication Type: Book chapter. Language: English. Number of References: 26 ref. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - The purpose of this chapter is to review approaches toward the evaluation of program effectiveness and fidelity. The intended audience for this chapter is primarily injury control and public health programme administrators and their staff. In this chapter, 2 specific scenarios frequently faced by programme administrators are discussed. The first is the development of an evaluation section of a funding proposal from a state government department of health to disseminate an injury prevention intervention. The second involves planning for a site visit to evaluate an injury prevention programme in a state or local health department. Both require extensive preparation and coordination of people and activities. Both require careful attention to programme implementation and evaluation strategies. It is believed that the execution of these scenarios illustrates some of the practical principles regarding the evaluation of program fidelity and effectiveness.
KW - disease prevention
KW - health policy
KW - human diseases
KW - public health
KW - trauma
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - traumas
KW - Policy and Planning (EE120)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083203793&site=ehost-live&scope=site
UR - email: bergerlaw@msn.com\navajo@u.washington.edu
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Mass medical care with scarce resources: a community planning guide.
AU - Phillips, S. J.
AU - Knebel, A.
A2 - Phillips, S. J.
A2 - Knebel, A.
T2 - Mass medical care with scarce resources: a community planning guide
T3 - AHRQ Publication No. 07-0001
Y1 - 2007///
CY - Rockville; USA
PB - Agency for Healthcare Research and Quality
AD - Phillips, S. J.: Public Health Emergency Preparedness Research Program, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20083157128. Publication Type: Book. Note: AHRQ Publication No. 07-0001 Language: English. Subject Subsets: Public Health
N2 - This planning guide looks at issues and challenges in a mass casualty event (MCE) response and preparedness issues across the spectrum of health care settings and provides recommendations for planners specific to each area. The planning guide begins with a discussion of the ethical and legal considerations and then discusses issues related to MCE planning in 3 care settings: prehospital, hospital and acute care, and alternative care sites (ACSs). This is followed by a discussion of palliative care issues, which must be integrated throughout the planning for and response to an MCE. The guide concludes with a presentation of a case study: an influenza pandemic. This guide will provide state and local planners with options to consider when planning their response to an MCE.
KW - emergencies
KW - ethics
KW - health care
KW - hospital care
KW - human diseases
KW - influenza
KW - influenza viruses
KW - law
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - flu
KW - Influenzavirus
KW - legal aspects
KW - legal principles
KW - palliative care
KW - Laws and Regulations (DD500)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083157128&site=ehost-live&scope=site
UR - http://www.ahrq.gov/research/mce/mceguide.pdf
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Packaging for foods treated by ionizing radiation.
AU - Komolprasert, V.
A2 - Han, J. H.
T2 - Packaging for nonthermal processing of food. 2005 IFT (Institute of Food Technologists) annual meeting, "Advances in Packaging Technology Required for Implementation on Novel Food Processes" and "Active Packaging for Nonthermal Processing", New Orleans, Louisiana, USA, 15-20 July 2005
Y1 - 2007///
CY - Oxford; UK
PB - Blackwell Publishing
SN - 9780813819440
AD - Komolprasert, V.: Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20073163876. Publication Type: Book chapter; Conference paper. Language: English. Number of References: many ref. Subject Subsets: Agricultural Engineering
N2 - This book chapter briefly describes: the food additive regulations pertaining to food and packaging materials in contact with food during irradiation; emerging research aimed at determining the radiolysis products formed from new packaging materials, including polymers and additives, after exposure to irradiation; and approaches to evaluate the pre-market safety assessment of new packaging materials in contact with food during irradiation.
KW - chemical composition
KW - food
KW - food additives
KW - food processing
KW - food safety
KW - food technology
KW - irradiation
KW - packaging materials
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Processing Equipment and Technology (NN600)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20073163876&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbiological quality of various medicinal herbal teas and coffee substitutes.
AU - Tournas, V. H.
AU - Katsoudas, E. J.
JO - Microbiology Insights
JF - Microbiology Insights
Y1 - 2008///
VL - 1
SP - 47
EP - 55
CY - Auckland; New Zealand
PB - Libertas Academica
SN - 1178-6361
AD - Tournas, V. H.: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20113352128. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Aromatic & Medicinal Plants; Human Nutrition; Horticultural Science; Postharvest Research; Plant Pathology
N2 - Various herbal teas including German chamomile, Chrysanthemum Vascuflow herb tea, hop, jasmine and orange flowers, sweet marjoram, spearmint and thyme leaves, and papaya-mint tea as well as coffee substitutes (Bambu instant Swiss, Teeccino chocolate-mint, and Teeccino Mediterranean Espresso) were analyzed for fungal contamination and the presence of aerobic mesophilic bacteria (APC). The results of this investigation showed that fungal counts reached levels as high as 5.8×105 colony forming units (cfu) per gram. German chamomile harbored the highest fungal contamination. The most common fungi found in herbal teas were Aspergillus niger, Penicillium spp., Eurotium rubrum, E. chevalieri, A. flavus, Fusarium spp., Alternaria alternata, and yeasts. Among the coffee substitutes, only the chocolate-mint coffee was contaminated with low numbers (<1.0×103 cfu g-1) of E. rubrum, Ulocladium spp. and Phoma spp., and with yeasts (<100-6.8×103 cfu g-1). Aerobic mesophilic bacteria were recovered from 100% of the herbal tea, chocolate-mint and Mediterranean Espresso, and from 50% of the Bambu instant Swiss coffee samples. The highest APC counts of 1.2×107 cfu g-1 were observed in spearmint leaves.
KW - coffee
KW - flowers
KW - food contamination
KW - food safety
KW - hops
KW - jasmine
KW - leaves
KW - microbial contamination
KW - tea
KW - yeasts
KW - Alternaria alternata
KW - Aspergillus flavus
KW - Aspergillus niger
KW - Bacteria
KW - Camellia sinensis
KW - Chamaemelum nobile
KW - Chrysanthemum
KW - Coffea
KW - Eurotium
KW - Fusarium
KW - Humulus lupulus
KW - Jasminum
KW - Origanum vulgare
KW - Penicillium
KW - Phoma
KW - Thymus vulgaris
KW - Ulocladium
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - bacterium
KW - prokaryotes
KW - Chamaemelum
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Eurotium
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Origanum
KW - Lamiaceae
KW - Lamiales
KW - Thymus
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - Humulus
KW - Cannabidaceae
KW - Urticales
KW - Oleaceae
KW - Scrophulariales
KW - Camellia
KW - Theaceae
KW - Theales
KW - bacterium
KW - Eurotium chevalierie
KW - Eurotium rubrum
KW - food contaminants
KW - fungus
KW - marjoram
KW - Oleales
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113352128&site=ehost-live&scope=site
UR - http://www.la-press.com/microbiological-quality-of-various-medicinal-herbal-teas-and-coffee-su-article-a1038
UR - email: valerie.tournas@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vancomycin-resistant Lactococcus lactis 1A-1 isolated from a competitive exclusion product transfers vancomycin resistance genes to Staphylococcus aureus.
AU - Wagner, R. D.
AU - Kurniasih-Rubin, D.
AU - Johnson, S. J.
JO - Open Food Science Journal
JF - Open Food Science Journal
Y1 - 2008///
VL - 2
SP - 72
EP - 76
CY - Bussum; Netherlands
PB - Bentham Open
SN - 1874-2564
AD - Wagner, R. D.: Division of Microbiology, National Center for Toxicological Research, HFT-250, 3900 NCTR Rd., Jefferson, AR 72022, USA.
N1 - Accession Number: 20093223683. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Registry Number: 1404-90-6, 1404-93-9. Subject Subsets: Human Nutrition
N2 - A vancomycin-resistant Lactococcus lactis isolate 1A-1 from a competitive exclusion (CE) product contained plasmid-encoded vanA, B, C1, and C2/3 genes. The L. lactis 1A-1 conjugatively transferred the genes to Staphylococcus aureus in vitro. CE product bacteria may be reservoirs for dissemination of vanA, B, and C genes to the human gastrointestinal microbiota.
KW - drug resistance
KW - gene transfer
KW - genes
KW - in vitro
KW - intestinal microorganisms
KW - vancomycin
KW - Lactococcus lactis
KW - Staphylococcus aureus
KW - Lactococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - bacterium
KW - gut flora
KW - intestinal micro-organisms
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093223683&site=ehost-live&scope=site
UR - http://www.bentham.org/open/tofsj/openaccess2.htm
UR - email: doug.wagner@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Emerging enteric and potentially waterborne pathogens.
AU - Cunliffe, D. A.
JO - Water Practice & Technology
JF - Water Practice & Technology
Y1 - 2008///
VL - 3
IS - 4
SP - 092
EP - 092
CY - London; UK
PB - IWA Publishing
SN - 1751-231X
AD - Cunliffe, D. A.: Public Health Service, Department of Health, PO Box 6, Rundle Mall, South Australia 5001, Australia.
N1 - Accession Number: 20093032902. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Tropical Diseases; Public Health; Protozoology
N2 - Infectious water-borne pathogens are a major cause of morbidity and mortality. A substantial proportion of water-borne disease is caused by established pathogens. However, emerging pathogens present important challenges to the water and health sectors. The last 30 to 40 years has seen the initial identification of a number of significant pathogens that can be water-borne including rotavirus, norovirus, V. cholerae 0139, Cryptosporidium, Campylobacter and Legionella. Many more are classified as emerging due to detection of increased incidence of disease or detection in areas where they were not previously established. The emergence of infectious diseases, including those that are water-borne, is caused by a number of factors such as population growth, migration, travel, new environments, climate change, improved methodology and drug resistance. Understanding these factors is an important component of establishing effective management of water resources and drinking water safety plans.
KW - climatic change
KW - drinking water
KW - drug resistance
KW - human diseases
KW - migration
KW - pathogens
KW - polluted water
KW - population growth
KW - public health
KW - water management
KW - water pollution
KW - water quality
KW - water resources
KW - waterborne diseases
KW - Campylobacter
KW - Cryptosporidium
KW - Legionella
KW - Norovirus
KW - Rotavirus
KW - Vibrio cholerae
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Caliciviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Reoviridae
KW - dsRNA viruses
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - bacterium
KW - climate change
KW - water composition and quality
KW - water resource management
KW - winter vomiting disease
KW - winter vomiting virus
KW - Water Resources (PP200)
KW - Meteorology and Climate (PP500)
KW - Pollution and Degradation (PP600)
KW - Demography (UU200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093032902&site=ehost-live&scope=site
UR - http://www.iwaponline.com/wpt/003/wpt0030092.htm
UR - email: david.cunliffe@health.sa.gov.au
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Issues when modeling benzene, toluene, and xylene exposures using a literature database.
AU - Hein, M. J.
AU - Waters, M. A.
AU - Wijngaarden, E. van
AU - Deddens, J. A.
AU - Stewart, P. A.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2008///
VL - 5
IS - 1
SP - 36
EP - 47
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Hein, M. J.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20083245028. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 71-43-2, 108-88-3, 1330-20-7. Subject Subsets: Public Health
N2 - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data.
KW - benzene
KW - exposure
KW - toluene
KW - toxicity
KW - toxicology
KW - xylene
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dimethylbenzene
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083245028&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a787378994~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessing total fungal concentrations on commercial passenger aircraft using mixed-effects modeling.
AU - McKernan, L. T.
AU - Hein, M. J.
AU - Wallingford, K. M.
AU - Burge, H.
AU - Herrick, R.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2008///
VL - 5
IS - 1
SP - 48
EP - 58
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - McKernan, L. T.: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA.
N1 - Accession Number: 20083245029. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health; Soils & Fertilizers; Medical & Veterinary Mycology
N2 - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n=12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value <0.0001) and inside the aircraft (p-value <0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak.
KW - air quality
KW - aircraft
KW - artificial ventilation
KW - microbial contamination
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083245029&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a787379685~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular epidemiological analysis and microbial source tracking of Salmonella enterica serovars in a preharvest turkey production environment.
AU - Nayak, R.
AU - Stewart-King, T.
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
Y1 - 2008///
VL - 5
IS - 2
SP - 115
EP - 126
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1535-3141
AD - Nayak, R.: National Center for Toxicological Research, Division of Microbiology, U.S. Department of Health and Human Services, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083152546. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; Veterinary Science; Poultry; Public Health
N2 - Epidemiological studies were conducted to source track and delineate horizontal transmission pathways of Salmonella serovars in a turkey production environment. Salmonella enterica serovar Heidelberg (n=111), Salmonella Senftenberg (n=14), Salmonella Muenster (n=10), unidentifiable "roughs" (n=5), Salmonella Anatum (n=3), and Salmonella Worthington (n=2) were isolated from the birds' cecal and crop contents, litter, environmental swabs, drinkers, and feed samples. These strains (n=145) were analyzed for their antimicrobial susceptibility profiles and the bacterial horizontal transmission pathways were tracked by XbaI-digested pulsed-field gel electrophoresis (PFGE) macrorestriction profiles. Nearly 79% of the strains were resistant to one or more antimicrobials, while 44% of the strains were resistant to two to six antimicrobials. Nearly 21% of the strains were susceptible to all of the antimicrobials tested. Twenty-seven distinct PFGE fingerprint profiles (90-95% similarity) were observed among 110 Salmonella Heidelberg strains (one strain was untypeable), and 13 of the 27 profiles (48%) elicited 100% similarity among the fingerprint patterns. The prevalence of Salmonella Heidelberg strains at weeks 2 (n=20), 10 (n=20), and 18 (n=70) among the sampled pens suggested cross-colonization among pens during the 20-week production cycle. Salmonella Heidelberg strains were first isolated from the birds at week 2, and identical fingerprint profiles of this serovar were subsequently isolated from birds within the same pen; birds in other pens; and litter, air, and swab samples at weeks 10 and 18, suggesting possible horizontal transmission of this serovar across the production facility during the grow-out period.
KW - antibacterial agents
KW - food contamination
KW - food production
KW - microbial contamination
KW - molecular epidemiology
KW - molecular genetics techniques
KW - poultry
KW - serovars
KW - susceptibility
KW - Salmonella enterica
KW - turkeys
KW - Meleagris
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - domesticated birds
KW - food contaminants
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152546&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/abs/10.1089/fpd.2007.0029
UR - email: Rajesh.Nayak@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational risk management of engineered nanoparticles.
AU - Schulte, P.
AU - Geraci, C.
AU - Zumwalde, R.
AU - Hoover, M.
AU - Kuempel, E.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2008///
VL - 5
IS - 4
SP - 239
EP - 249
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Schulte, P.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20083245039. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Public Health
N2 - The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring.
KW - exposure
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - occupations
KW - protective clothing
KW - safety at work
KW - toxicity
KW - work places
KW - occupational safety
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Biosensors and Biological Nanotechnology (WW900) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083245039&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a790488094~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Food microbial pathogen detection and analysis using DNA microarray technologies.
AU - Rasooly, A.
AU - Herold, K. E.
A2 - Fratamico, P. M.
T3 - Special issue on the application of "omics" technologies for food safety research.
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
Y1 - 2008///
VL - 5
IS - 4
SP - 531
EP - 550
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1535-3141
AD - Rasooly, A.: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland, USA.
N1 - Accession Number: 20083229251. Publication Type: Journal Article. Note: Special issue on the application of "omics" technologies for food safety research. Language: English. Number of References: many ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Culture-based methods used for microbial detection and identification are simple to use, relatively inexpensive, and sensitive. However, culture-based methods are too time-consuming for high-throughput testing and too tedious for analysis of samples with multiple organisms and provide little clinical information regarding the pathogen (e.g., antibiotic resistance genes, virulence factors, or strain subtype). DNA-based methods, such as polymerase chain reaction (PCR), overcome some these limitations since they are generally faster and can provide more information than culture-based methods. One limitation of traditional PCR-based methods is that they are normally limited to the analysis of a single pathogen, a small group of related pathogens, or a small number of relevant genes. Microarray technology enables a significant expansion of the capability of DNA-based methods in terms of the number of DNA sequences that can be analyzed simultaneously, enabling molecular identification and characterization of multiple pathogens and many genes in a single array assay. Microarray analysis of microbial pathogens has potential uses in research, food safety, medical, agricultural, regulatory, public health, and industrial settings. In this article, we describe the main technical elements of microarray technology and the application and potential use of DNA microarrays for food microbial analysis.
KW - DNA
KW - DNA microarrays
KW - food contamination
KW - food safety
KW - foods
KW - gene expression
KW - genes
KW - microbial contamination
KW - molecular genetics
KW - molecular genetics techniques
KW - nucleotide sequences
KW - reviews
KW - bacteria
KW - prokaryotes
KW - bacterium
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - DNA sequences
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083229251&site=ehost-live&scope=site
UR - http://www.liebertonline.com/fpd
UR - email: rasoolya@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES.
AU - Johnson-Taylor, W. L.
AU - Fisher, R. A.
AU - Hubbard, V. S.
AU - Starke-Reed, P.
AU - Eggers, P. S.
JO - International Journal of Behavioral Nutrition and Physical Activity
JF - International Journal of Behavioral Nutrition and Physical Activity
Y1 - 2008///
VL - 5
IS - 9
SP - (12 February 2008)
EP - (12 February 2008)
CY - London; UK
PB - BioMed Central Ltd
SN - 1479-5868
AD - Johnson-Taylor, W. L.: US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, Maryland, USA.
N1 - Accession Number: 20083082779. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Objectives: This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods: The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m2) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results: Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion: The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004) has been accompanied with fewer overweight people perceiving themselves as overweight.
KW - attitudes
KW - body weight
KW - ethnicity
KW - income
KW - men
KW - obesity
KW - overweight
KW - self perception
KW - sex differences
KW - underweight
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - fatness
KW - self concept
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083082779&site=ehost-live&scope=site
UR - http://www.ijbnpa.org/content/pdf/1479-5868-5-9.pdf
UR - email: wj50v@nih.gov\fisherrachel@mail.nih.gov\hubbardv@mail.nih.gov\starkep@mail.nih.gov\eggersp@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Expectations training for miners using self-contained self-rescuers in escapes from underground coal mines.
AU - Kowalski-Trakofler, K. M.
AU - Vaught, C.
AU - Brnich, M. J., Jr.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2008///
VL - 5
IS - 10
SP - 671
EP - 677
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Kowalski-Trakofler, K. M.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA.
N1 - Accession Number: 20093010272. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - National Institute for Occupational Safety and Health researchers conducted a study to investigate the human response issues related to wearing a self-contained self-rescuer (SCSR). The goal was to develop training to educate miners on what they could expect from their units during an escape. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Results identified nine key areas of concern: (1) starting the unit, (2) unit heat, (3) induction of coughing, (4) unit taste, (5) difficulty in breathing while wearing the unit, (6) quality of the air supplied, (7) nose clips, (8) goggles, and (9) the behaviour of the breathing bag. In addition, researchers reviewed the literature on human response under duress. This article describes the expectations training program, which comprises the findings of the SCSR study and what is known about the normal human response in an emergency. The authors present background on SCSRs and the SCSR switchover procedure mandated in the recent federal Mine Improvement and New Emergency Response Act of 2006, which provided the impetus for the expectations training.
KW - emergencies
KW - instruments
KW - miners
KW - occupational hazards
KW - occupational health
KW - protective clothing
KW - safety at work
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093010272&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a795446204~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A simple and rapid Hepatitis A Virus (HAV) titration assay based on antibiotic resistance of infected cells: evaluation of the HAV neutralization potency of human immune globulin preparations.
AU - Konduru, K.
AU - Virata-Theimer, M. L.
AU - Yu, M. Y. W.
AU - Kaplan, G. G.
JO - Virology Journal
JF - Virology Journal
Y1 - 2008///
VL - 5
IS - 155
SP - (18 December 2008)
EP - (18 December 2008)
CY - London; UK
PB - BioMed Central Ltd
SN - 1743-422x
AD - Konduru, K.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093141432. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 2079-00-7, 308067-57-4. Subject Subsets: Public Health
N2 - Background: Hepatitis A virus (HAV), the causative agent of acute hepatitis in humans, is an atypical Picornaviridae that grows poorly in cell culture. HAV titrations are laborious and time-consuming because the virus in general does not cause cytopathic effect and is detected by immunochemical or molecular probes. Simple HAV titration assays could be developed using currently available viral construct containing selectable markers. Results: We developed an antibiotic resistance titration assay (ARTA) based on the infection of human hepatoma cells with a wild type HAV construct containing a blasticidin (Bsd) resistance gene. Human hepatoma cells infected with the HAV-Bsd construct survived selection with 2 µg/ml of blasticidin whereas uninfected cells died within a few days. At 8 days postinfection, the color of the pH indicator phenol red in cell culture media correlated with the presence of HAV-Bsd-infected blasticidin-resistant cells: an orange-to-yellow color indicated the presence of growing cells whereas a pink-to-purple color indicated that the cells were dead. HAV-Bsd titers were determined by an endpoint dilution assay based on the color of the cell culture medium scoring orange-to-yellow wells as positive and pink-to-purple wells as negative for HAV. As a proof-of-concept, we used the ARTA to evaluate the HAV neutralization potency of two commercially available human immune globulin (IG) preparations and a WHO International Standard for anti-HAV. The three IG preparations contained comparable levels of anti-HAV antibodies that neutralized approximately 1.5 log of HAV-Bsd. Similar neutralization results were obtained in the absence of blasticidin by an endpoint dilution ELISA at 2 weeks postinfection. Conclusion: The ARTA is a simple and rapid method to determine HAV titers without using HAV-specific probes. We determined the HAV neutralization potency of human IG preparations in 8 days by ARTA compared to the 14 days required by the endpoint dilution ELISA. The ARTA reduced the labour, time, and cost of HAV titrations making it suitable for high throughput screening of sera and antivirals, determination of anti-HAV antibodies in human immune globulin preparations, and research applications that involve the routine evaluation of HAV titers.
KW - antiviral agents
KW - assays
KW - blasticidin-S
KW - drug resistance
KW - ELISA
KW - hepatitis A
KW - immune response
KW - immunoglobulins
KW - immunological techniques
KW - in vitro
KW - methodology
KW - serology
KW - techniques
KW - viral diseases
KW - Hepatitis A virus
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - enzyme linked immunosorbent assay
KW - gamma-globulins
KW - immune globulins
KW - immunity reactions
KW - immunological reactions
KW - methods
KW - serological techniques
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093141432&site=ehost-live&scope=site
UR - http://www.virologyj.com/content/5/1/155
UR - email: Krishnamurthy.konduru@fda.hhs.gov\marialuisa.virata@fda.hhs.gov\mei-ying.yu@fda.hhs.gov\gk@helix.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Non-traditional vectors for paralytic shellfish poisoning.
AU - Deeds, J. R.
AU - Landsberg, J. H.
AU - Etheridge, S. M.
AU - Pitcher, G. C.
AU - Longan, S. W.
JO - Marine Drugs
JF - Marine Drugs
Y1 - 2008///
VL - 6
IS - 2
SP - 308
EP - 348
CY - Basel; Switzerland
PB - Molecular Diversity Preservation International (MDPA)
SN - 1660-3397
AD - Deeds, J. R.: US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20723, USA.
N1 - Accession Number: 20093218858. Publication Type: Journal Article. Language: English. Number of References: 218 ref. Subject Subsets: Weeds; Medical & Veterinary Entomology; Protozoology; Human Nutrition
N2 - Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, are also produced in freshwater cyanobacteria and have been associated with calcareous red macroalgae. STXs are transferred and bioaccumulate throughout aquatic food webs, and can be vectored to terrestrial biota, including humans. Fisheries closures and human intoxications due to STXs have been documented in several non-traditional (i.e. non-filter-feeding) vectors. These include, but are not limited to, marine gastropods, both carnivorous and grazing, crustacea, and fish that acquire STXs through toxin transfer. Often due to spatial, temporal, or a species disconnection from the primary source of STXs (bloom forming dinoflagellates), monitoring and management of such non-traditional PSP vectors has been challenging. A brief literature review is provided for filter feeding (traditional) and nonfilter feeding (non-traditional) vectors of STXs with specific reference to human effects. We include several case studies pertaining to management actions to prevent PSP, as well as food poisoning incidents from STX(s) accumulation in non-traditional PSP vectors.
KW - bioaccumulation
KW - food contamination
KW - food hygiene
KW - food poisoning
KW - food safety
KW - paralytic shellfish poisoning
KW - poisoning
KW - reviews
KW - shellfish
KW - toxicity
KW - toxins
KW - algae
KW - Crustacea
KW - Dinoflagellida
KW - fishes
KW - Gastropoda
KW - plants
KW - aquatic plants
KW - aquatic organisms
KW - eukaryotes
KW - arthropods
KW - invertebrates
KW - animals
KW - Sarcomastigophora
KW - Protozoa
KW - vertebrates
KW - Chordata
KW - aquatic animals
KW - Mollusca
KW - food contaminants
KW - toxicosis
KW - Weeds and Noxious Plants (FF500)
KW - Aquatic Biology and Ecology (MM300)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Toxicology and Poisoning (Wild Animals) (YY900) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093218858&site=ehost-live&scope=site
UR - http://www.mdpi.com/1660-3397/6/2/308/pdf
UR - email: jonathan.deeds@fda.hhs.gov\jan.landsberg@myfwc.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - CDC mental health work group advances a neglected part of public health.
AU - Safran, M. A.
T3 - Behavioral and Mental Health
JO - NACCHO Exchange
JF - NACCHO Exchange
Y1 - 2008///
VL - 7
IS - 3
SP - 15
EP - 15
CY - Washington; USA
PB - National Association of County and City Health Officials
AD - Safran, M. A.: U.S. Public Health Service, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20103326300. Publication Type: Journal Article. Note: Behavioral and Mental Health Language: English. Subject Subsets: Public Health
KW - health care
KW - health promotion
KW - mental health
KW - public health
KW - public health services
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103326300&site=ehost-live&scope=site
UR - http://www.cabi.org/cabdirect/showpdf.aspx?PAN=http://www.cabi.org/cabdirect/showpdf.aspx?PAN=20103326300
UR - http://www.naccho.org
UR - email: mas9@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry.
AU - McKernan, L. T.
AU - Ruder, A. M.
AU - Petersen, M. R.
AU - Hein, M. J.
AU - Forrester, C. L.
AU - Sanderson, W. T.
AU - Ashley, D. L.
AU - Butler, M. A.
JO - Environmental Health
JF - Environmental Health
Y1 - 2008///
VL - 7
IS - 12
SP - (15 A
EP - (15 A
CY - London; UK
PB - BioMed Central Ltd
SN - 1476-069X
AD - McKernan, L. T.: Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083131996. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 127-18-4. Subject Subsets: Public Health
N2 - Background: The purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects. Methods: Eighteen women from four dry cleaning facilities in southwestern Ohio were monitored in a pilot study of workers with PCE exposure. Personal breathing zone samples were collected from each employee on two consecutive work days. Biological monitoring included a single measurement of PCE in blood and multiple measurements of pre- and post-shift PCE in exhaled breath and trichloroacetic acid (TCA) in urine. Results: Post-shift PCE in exhaled breath gradually increased throughout the work week. Statistically significant correlations were observed among the exposure indices. Decreases in PCE in exhaled breath and TCA in urine were observed after two days without exposure to PCE. A mixed-effects model identified statistically significant associations between PCE in exhaled breath and airborne PCE time weighted average (TWA) after adjusting for a random participant effect and fixed effects of time and body mass index. Conclusion: Although comprehensive, our sampling strategy was challenging to implement due to fluctuating work schedules and the number (pre- and post-shift on three consecutive days) and multiplicity (air, blood, exhaled breath, and urine) of samples collected. PCE in blood is the preferred biological index to monitor exposures, but may make recruitment difficult. PCE TWA sampling is an appropriate surrogate, although more field intensive. Repeated measures of exposure and mixed-effects modeling may be required for future studies due to high within-subject variability. Workers should be monitored over a long enough period of time to allow the use of a lag term.
KW - air pollutants
KW - air pollution
KW - air quality
KW - blood
KW - breath
KW - dry cleaning workers
KW - exposure
KW - occupational hazards
KW - occupational health
KW - tetrachloroethylene
KW - urine
KW - women
KW - Ohio
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - atmospheric pollution
KW - perchloroethylene
KW - tetrachloroethene
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083131996&site=ehost-live&scope=site
UR - http://www.ehjournal.net/content/pdf/1476-069X-7-12.pdf
UR - email: LTaylor@cdc.gov\ARuder@cdc.gov\MPetersen@cdc.gov\MHein@cdc.gov\CForrester@cdc.gov\wayne-sanderson@uiowa.edu\DAshley@cdc.gov\MButler@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - West Nile Virus neuroinvasive disease incidence in the United States, 2002-2006.
AU - Lindsey, N. P.
AU - Kuhn, S.
AU - Campbell, G. L.
AU - Hayes, E. B.
JO - Vector Borne and Zoonotic Diseases
JF - Vector Borne and Zoonotic Diseases
Y1 - 2008///
VL - 8
IS - 1
SP - 35
EP - 40
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1530-3667
AD - Lindsey, N. P.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, 1350 Rampart Road, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20083058729. Publication Type: Journal Article. Language: English. Number of References: 6 ref. Subject Subsets: Veterinary Science; Public Health; Medical & Veterinary Entomology; Veterinary Science
N2 - As the geographic range of reported human West Nile virus (WNV) disease has expanded across the United States, seasonal transmission and outbreaks have persisted over several years in many areas of the country. West Nile virus neuroinvasive disease (WNND) case reports from 2002 to 2006 were reviewed to determine which areas of the country have the highest reported cumulative incidence and whether those areas have had consistently high annual incidence. During the 5-year period examined, 9632 cases of WNND were reported nationwide. The cumulative incidence of WNND ranged from 0.2 to 32.2 per 100,000 population by state and from 0.1 to 241.2 per 100,000 population by county. States and counties with the highest cumulative incidence were primarily located in the northern Great Plains. States with consistently high annual incidence included South Dakota, North Dakota, Wyoming, New Mexico, Mississippi, Nebraska, Louisiana, and Colorado. All of these states, with the exception of New Mexico, were also among the states with the highest cumulative incidence. Counties with repeatedly high annual incidence were also primarily in the Great Plains and mid-South. The risk of WNND appears to be highest in areas where the primary WNV vectors are Culex tarsalis and Cx. quinquefasciatus mosquitoes.
KW - disease distribution
KW - disease prevalence
KW - disease transmission
KW - disease vectors
KW - epidemiology
KW - geographical variation
KW - outbreaks
KW - public health
KW - spread
KW - vector control
KW - vector-borne diseases
KW - West Nile fever
KW - zoonoses
KW - Colorado
KW - Louisiana
KW - Mississippi
KW - Nebraska
KW - New Mexico
KW - North Dakota
KW - South Dakota
KW - USA
KW - Wyoming
KW - Culex quinquefasciatus
KW - Culex tarsalis
KW - man
KW - West Nile virus
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - Delta States of USA
KW - Southern States of USA
KW - Gulf States of USA
KW - West South Central States of USA
KW - East South Central States of USA
KW - Northern Plains States of USA
KW - West North Central States of USA
KW - North Central States of USA
KW - Southwestern States of USA
KW - United States of America
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083058729&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/pdfplus/10.1089/vbz.2007.0137
UR - email: nplindsey@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Annual report on health care for children and youth in the United States: focus on injury-related emergency department utilization and expenditures.
AU - Owens, P. L.
AU - Zodet, M. W.
AU - Berdahl, T.
AU - Dougherty, D.
AU - McCormick, M. C.
AU - Simpson, L. A.
T2 - Ambulatory Pediatrics
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
Y1 - 2008///
VL - 8
IS - 4
SP - 219
EP - 240
CY - New York; USA
PB - Elsevier
SN - 1530-1567
AD - Owens, P. L.: Agency for Healthcare, Research and Quality, Department of Health and Human Services, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20083206718. Publication Type: Journal Article. Language: English. Number of References: 64 ref. Subject Subsets: Public Health
N2 - Objective. - To examine state differences in children's utilization of injury-related emergency department (ED) care across 14 states, benchmarking aggregate state estimates against national expenditure estimates for outpatient injury-related ED care. Methods. - A retrospective analysis was performed using the 2003 State Emergency Department Databases and State Inpatient Databases from the Healthcare Cost and Utilization Project and data from the Medical Expenditure Panel Survey. Pediatric ED visits with any injury International Classification of Diseases Ninth Version Clinical Modification (ICD-9-CM) diagnosis code were selected. The Barell Injury Diagnosis Matrix, ICD-MAP-90 software, and the Trauma Information Exchange Program data were used to classify injuries, produce injury severity scores, and examine utilization in trauma centers. Aggregate and state-specific descriptive analyses compared differences in patient and injury characteristics and admission status by age, severity of injury, and expected payer. Results. - Over 1.5 million or nearly one-third of ED visits were for pediatric injuries in the 14 states studied. Nationally, 5.4% of children had an injury-related ED visit, and approximately $2.3 billion was spent on outpatient injury-related ED visits in 2003. The pattern of injury-related ED visit care varied considerably by state. For example, injury-related ED visit rates ranged from 63.3 to 164.4 per 1000 children. Infants, adolescents, children from very low income communities, and children from nonmetropolitan and nonmicropolitan areas were more likely to have an injury-related ED visit than their peers. Although patient characteristics were fairly consistent across states, admission rates and expected source of payment for injury-related ED visits varied considerably by state. Hospital admission rates ranged from 1.5% to 4.4% of injury-related ED visits and expected payer estimates ranged from 37.1% to 71.0% of visits billed to private insurance, 17.9% to 47.0% billed to Medicaid, and 2.1% to 10.4% billed as uninsured. Conclusions. - This study suggests that injuries account for a significant portion of pediatric ED visits. There is substantial variation in ED use and hospital admissions for injured children across states and payers. This variation suggests that there are several opportunities for improvement in emergency care for children. To better understand the underlying reason for the variation, multivariate and hypothesis-driven research should focus on the nature and outcomes of injury-related ED care in the context of small area practice patterns and state programs, policies, and care system characteristics.
KW - children
KW - epidemiology
KW - health care
KW - health care costs
KW - health services
KW - human diseases
KW - trauma
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - traumas
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083206718&site=ehost-live&scope=site
UR - http://www.ambulatorypediatrics.org
UR - email: Pamela.Owens@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Parental perceptions of dental/oral health among children with and without special health care needs.
AU - Kenney, M. K.
AU - Kogan, M. D.
AU - Crall, J. J.
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
Y1 - 2008///
VL - 8
IS - 5
SP - 312
EP - 320
CY - New York; USA
PB - Elsevier
SN - 1530-1567
AD - Kenney, M. K.: U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Rm 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083288363. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - Objectives. - The aims of this study were to determine the prevalence of parent-reported preventive dental care and better dental health in children with special health care needs (CSHCN) and to identify parent-reported dental problems, reasons for lack of preventive dental care, and factors associated with receiving preventive care and having better perceived dental health in CSHCN. A comparison group of children without special needs (CWOSN) was included. Methods. - We analyzed the 2003 National Survey of Children's Health by using a sample of 17 001 CSHCN and a comparison group of CWOSN. Descriptive and between-group chi-square statistics were used to analyze child characteristics, parent-perceived dental problems, and reasons for lack of preventive dental care. Factors associated with receipt of preventive dental care and better reported dental health were examined using logistic regression. Results. - Approximately 80% of CSHCN and 72% of CWOSN received preventive dental care. CSHCN parents reported more dental problems and fewer described their children as having good to excellent dental health compared to CWOSN, despite greater odds of having dental coverage and receiving preventive dental care. Disparities were evident in preventive dental care and dental health based on income, education, and insurance coverage. Conclusions. - Most parents of CSHCN and CWOSN report that their children receive preventive dental care and have good to excellent dental health; however, disparities in dental health and receipt of preventive dental care exist. Accessing care coordination by using the medical/dental home model, particularly for CSHCN, may alleviate the situation in which some of the most vulnerable children are experiencing the worst dental health.
KW - asthma
KW - attitudes
KW - children
KW - children with disabilities
KW - dental health
KW - disease prevention
KW - education
KW - health care
KW - health insurance
KW - hearing impairment
KW - human diseases
KW - mental disorders
KW - parents
KW - socioeconomic status
KW - teeth
KW - tooth diseases
KW - vision disorders
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - attention deficit disorder with hyperactivity
KW - autistic disorder
KW - handicapped children
KW - mental illness
KW - psychiatric disorders
KW - United States of America
KW - visual impairments
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083288363&site=ehost-live&scope=site
UR - http://www.ambulatorypediatrics.org
UR - email: mkenney@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Increased recognition of Powassan encephalitis in the United States, 1999-2005.
AU - Hinten, S. R.
AU - Beckett, G. A.
AU - Gensheimer, K. F.
AU - Pritchard, E.
AU - Courtney, T. M.
AU - Sears, S. D.
AU - Woytowicz, J. M.
AU - Preston, D. G.
AU - Smith, R. P., Jr.
AU - Rand, P. W.
AU - Lacombe, E. H.
AU - Holman, M. S.
AU - Lubelczyk, C. B.
AU - Kelso, P. T.
AU - Beelen, A. P.
AU - Stobierski, M. G.
AU - Sotir, M. J.
AU - Wong, S.
AU - Ebel, G.
AU - Kosoy, O.
AU - Piesman, J.
AU - Campbell, G. L.
AU - Marfin, A. A.
JO - Vector Borne and Zoonotic Diseases
JF - Vector Borne and Zoonotic Diseases
Y1 - 2008///
VL - 8
IS - 6
SP - 733
EP - 740
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1530-3667
AD - Hinten, S. R.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Fort Collins, CO 80522, USA.
N1 - Accession Number: 20093013252. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Veterinary Science; Public Health; Medical & Veterinary Entomology
N2 - Powassan virus (POWV) disease is a rare human disease caused by a tick-borne encephalitis group flavivirus maintained in a transmission cycle between Ixodes cookei and other ixodid ticks and small and medium-sized mammals. During 1958-1998, only 27 POWV disease cases (mostly Powassan encephalitis) were reported from eastern Canada and the northeastern United States (average, 0.7 cases per year). During 1999-2005, nine cases (described herein) of serologically confirmed POWV disease were reported in the United States (average, 1.3 cases per year): four from Maine, two from New York, and one each from Michigan, Vermont, and Wisconsin. The Michigan and Wisconsin cases are the first ever reported from the north-central United States. Of these nine patients, 5 (56%) were men, the median age was 69 years (range: 25-91 years), and 6 (67%) had onset during May-July. All but one patient developed encephalitis with acute onset of profound muscle weakness, confusion, and other severe neurologic signs. In one case, no neurologic symptoms were present but the presence of pleocytosis, an elevated cerebrospinal fluid (CSF) protein concentration, and POWV-specific immunoglobulin M in CSF suggested neuroinvasion. All patients recovered from their acute disease, but most had long-term neurologic sequelae. Periresidential ecologic investigations were performed in three cases, including tests of local mammals and ticks for evidence of POWV infection. Woodchucks (Marmota monax), striped skunks (Mephitis mephitis), and a raccoon (Procyon lotor) collected at two of the Maine case-patients' residences had neutralizing antibody titers to POWV. I. cookei were found on woodchucks and skunks and questing in grassy areas of one of these residences; all were negative for POWV. Although POWV disease is rare, it is probably under-recognized, and it causes significant morbidity, and thus is an additional tick-borne emerging infectious disease entity. Because no vaccine or specific therapy is available, the basis of prevention is personal protection from ticks (or "tick hygiene") and reduced exposure to peridomestic wild mammals.
KW - disease vectors
KW - encephalitis
KW - human diseases
KW - tickborne diseases
KW - wild animals
KW - Canada
KW - Maine
KW - Michigan
KW - New York
KW - USA
KW - Vermont
KW - Wisconsin
KW - Ixodes cookei
KW - man
KW - Marmota monax
KW - Mephitis mephitis
KW - Powassan virus
KW - Procyon
KW - Ixodes
KW - Ixodidae
KW - Metastigmata
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Marmota
KW - Sciuridae
KW - rodents
KW - Mephitis
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Procyonidae
KW - APEC countries
KW - Commonwealth of Nations
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - New England States of USA
KW - Northeastern States of USA
KW - USA
KW - East North Central States of USA
KW - North Central States of USA
KW - Lake States of USA
KW - Middle Atlantic States of USA
KW - encephalomyelitis
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093013252&site=ehost-live&scope=site
UR - http://www.liebertonline.com/vbz
UR - email: JPiesman@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats.
AU - Xie QiangMin
AU - Wu XiMei
AU - Wu HuiMin
AU - Deng YangMei
AU - Zhang ShuiJuan
AU - Zhu JianPing
AU - Dong XinWei
JO - International Immunopharmacology
JF - International Immunopharmacology
Y1 - 2008///
VL - 8
IS - 12
SP - 1639
EP - 1645
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1567-5769
AD - Xie QiangMin: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration, Medical Science College of Zhejiang University, 388 Yuhangtang Rd. Hangzhou City, Zhejiang Province 310058, China.
N1 - Accession Number: 20083272012. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 37341-29-0, 308067-58-5, 9008-11-1, 207137-56-2. Subject Subsets: Medical & Veterinary Entomology
N2 - Clinically sublingual immunotherapy (SLIT) by using allergen extracts effectively alleviates the symptoms of allergic rhinitis and asthma. Supposed that oral administration of high-dose of allergen extracts imitates SLIT and may prevent IgE-related responses in allergic diseases, we investigated the effects of oral administration of allergen extracts from Dermatophagoides farinae (Derf) on allergen-induced inflammation and airway hyperresponsiveness (AHR) in a model of asthmatic rat. After administration to the specific Derf-sensitized rats with Derfdrop solution containing Derf1 and Derf2 extracts derived from Derf, the effects of Derfdrop on AHR, inflammatory cell accumulation, cytokine production in the bronchoalveolar lavage fluid and lung tissue, as well as serum IgE and IgG levels were investigated. Results indicated that Derfdrop not only dose-dependently prevented the AHR in response to methacholine, but also significantly reduced the serum total and allergen-specific IgE levels, all the maximal effects were achieved at dose of 5 mg/kg/d, and were as comparable as those of dexamethasone at dose of 1.0 mg/kg/d. Furthermore, oral administration of Derfdrop not only dose-dependently elevated allergen-specific serum IgG levels and reduced total and allergen-specific IgE levels, but also normalized the imbalance between the Th1 cytokine, IFN-γ and Th2 cytokine, IL-4. Finally, oral administration of Derfdrop significantly reduced Goblet cell hyperplasia and eosinophilia in the Derf-sensitized allergic rat model. These data suggest that Derfdrop effectively improves specific allergen-induced inflammation and AHR in Derf-sensitized and -challenged rats and provide with the rationale for clinical SLIT by using Derfdrop in a specific allergen-induced asthma.
KW - allergens
KW - animal models
KW - arthropod allergies
KW - asthma
KW - cell mediated immunity
KW - cytokines
KW - human diseases
KW - IgE
KW - IgG
KW - immune response
KW - immunotherapy
KW - inflammation
KW - interferon
KW - interleukin 4
KW - laboratory animals
KW - respiratory hypersensitivity
KW - T lymphocytes
KW - Dermatophagoides farinae
KW - rats
KW - Dermatophagoides
KW - Pyroglyphidae
KW - Astigmata
KW - mites
KW - Acari
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - cellular immunity
KW - immunity reactions
KW - immunological reactions
KW - reagin
KW - reaginic antibodies
KW - T cells
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083272012&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/15675769
UR - email: xieqm@zju.edu.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Early and late tuberculosis risks among close contacts in Hong Kong.
AU - Lee, M. S. N.
AU - Leung, C. C.
AU - Kam, K. M.
AU - Wong, M. Y.
AU - Leung, M. C. M.
AU - Tamn, C. M.
AU - Leung, E. C. C.
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
Y1 - 2008///
VL - 12
IS - 3
SP - 281
EP - 287
CY - Paris; France
PB - International Union Against Tuberculosis and Lung Disease (IUATLD)
SN - 1027-3719
AD - Lee, M. S. N.: Tuberculosis and Chest Service, Public Health Service Branch, Centre of Health Protection, Department of Health, Hong Kong.
N1 - Accession Number: 20083082369. Publication Type: Journal Article. Language: English. Language of Summary: Spanish; French. Number of References: 28 ref. Subject Subsets: Tropical Diseases
N2 - SETTING: Tuberculosis (TB) notification is a statutory requirement in Hong Kong, where contact investigations are performed by the Tuberculosis and Chest Service. OBJECTIVES: (1) To evaluate the risk of active TB in close contacts within 5 years, and (2) to identify risk factors associated with early and late development of active TB disease. DESIGN: The characteristics of consecutive TB cases notified from 18 January to 17 April 2000 were collected together with those of their contacts. Contacts were prospectively followed up through the territory-wide TB notification registry for 5 years for the development of disease. RESULTS: A total of 1537 index cases and 4661 close contacts were analysed. Screening found 31 (0.67%) aclive TB cases within a 3-month period, and another 58 (1.24%) cases presented subsequently. Index cases with cough or pulmonary cavities and diabetic contacts were independent risk factors of early cases (all P<0.05). Adjusted at risk index characteristics for late TB development included positive sputum smear (2.79, 95% CI 1.31-5.95) and family history of TB (4.26, 95% CI 2.01-9.03). Contact risk factors included diabetes mellitus (3.44, 95% CI 1.04-11.33) and institutionalisation (3.61, 95% CI 1.70-7.65). CONCLUSION: Considerable TB risk remains after initial contact screening. A number of possible risk factors were identified.
KW - contacts
KW - human diseases
KW - morbidity
KW - risk
KW - risk factors
KW - screening
KW - tuberculosis
KW - China
KW - Hong Kong
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Central Southern China
KW - China
KW - bacterium
KW - People's Republic of China
KW - screening tests
KW - Xianggang
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083082369&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/iuatld/ijtld
UR - email: sn_lee@dh.gov.hk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
AU - Baum, A. E.
AU - Akula, N.
AU - Cabanero, M.
AU - Cardona, I.
AU - Corona, W.
AU - Klemens, B.
AU - Schulze, T. G.
AU - Cichon, S.
AU - Rietschel, M.
AU - Nöthen, M. M.
AU - Georgi, A.
AU - Schumacher, J.
AU - Schwarz, M.
AU - Jamra, R. A.
AU - Höfels, S.
AU - Propping, P.
AU - Satagopan, J.
AU - Detera-Wadleigh, S. D.
AU - Hardy, J.
AU - McMahon, F. J.
JO - Molecular Psychiatry
JF - Molecular Psychiatry
Y1 - 2008///
VL - 13
IS - 2
SP - 197
EP - 207
CY - London; UK
PB - Nature Publishing Group
SN - 1359-4184
AD - Baum, A. E.: Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, US Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, 1A-202, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083075267. Publication Type: Journal Article. Corporate Author: USA, NIMH Genetics Initiative Bipolar Disorder Consortium Language: English. Subject Subsets: Public Health
N2 - The genetic basis of bipolar disorder has long been thought to be complex, with the potential involvement of multiple genes, but methods to analyze populations with respect to this complexity have only recently become available. We have carried out a genome-wide association study of bipolar disorder by genotyping over 550 000 single-nucleotide polymorphisms (SNPs) in two independent case-control samples of European origin. The initial association screen was performed using pooled DNA, and selected SNPs were confirmed by individual genotyping. While DNA pooling reduces power to detect genetic associations, there is a substantial cost saving and gain in efficiency. A total of 88 SNPs, representing 80 different genes, met the prior criteria for replication in both samples. Effect sizes were modest: no single SNP of large effect was detected. Of 37 SNPs selected for individual genotyping, the strongest association signal was detected at a marker within the first intron of diacylglycerol kinase eta (DGKH; P=1.5×10-8, experiment-wide P<0.01, OR=1.59). This gene encodes DGKH, a key protein in the lithium-sensitive phosphatidyl inositol pathway. This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease.
KW - bipolar disorder
KW - diacylglycerols
KW - genetic factors
KW - human diseases
KW - introns
KW - mental disorders
KW - molecular biology
KW - molecular genetics
KW - single nucleotide polymorphism
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - diglycerides
KW - manic depression
KW - mental illness
KW - psychiatric disorders
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083075267&site=ehost-live&scope=site
UR - http://www.nature.com/mp/journal/v13/n2/abs/4002012a.html
UR - email: mcmahonf@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of asthma among youth on hispanic-operated farms in the United States - 2000.
AU - Syamlal, G.
AU - Mazurek, J. M.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2008///
VL - 13
IS - 3
SP - 155
EP - 164
CY - Binghamton; USA
PB - Haworth Press Inc.
SN - 1059-924X
AD - Syamlal, G.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Mail Stop HG900.2, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093023758. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p<.05) and serious asthma attacks (1.6% versus 1.3%; p>.05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p<.05) and among youth living on livestock farms than among youth on crop farms (9.4% versus 7.4%; p<.05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations.
KW - asthma
KW - disease prevalence
KW - ethnic groups
KW - ethnicity
KW - farm workers
KW - farms
KW - Hispanics
KW - human diseases
KW - young workers
KW - youth
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - United States of America
KW - youth employment
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093023758&site=ehost-live&scope=site
UR - http://www.haworthpress.com/store/product.asp?sku=J096
UR - email: gos2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A cluster of hepatitis B infections associated with incorrect use of a capillary blood sampling device in a nursing home in the Netherlands, 2007.
AU - Götz, H. M.
AU - Schutten, M.
AU - Borsboom, G. J.
AU - Hendriks, B.
AU - Doornum, G. van
AU - Zwart, O. de
JO - Eurosurveillance
JF - Eurosurveillance
Y1 - 2008///
VL - 13
IS - 27
SP - 18918
EP - 18918
CY - Saint-Maurice; France
PB - Eurosurveillance
AD - Götz, H. M.: Division of Infectious Disease Control, Municipal Public Health Service Rotterdam Rijnmond, Rotterdam, Netherlands.
N1 - Accession Number: 20093070303. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - In July 2007, two residents of a nursing home were diagnosed with acute Hepatitis B virus infection. To identify risk factors for HBV infection a retrospective cohort study among residents was performed. Case finding included discharged diabetes patients and those receiving home care. Among 32 residents one case of chronic hepatitis B was found that could be identified by genotyping as the source patient for the acute cases. Diabetes and finger sticks were risk factors for HBV infection. Most likely the cause of transmission was a multiclix finger stick device developed for use in individual patients but used in multiple patients. Education and training in the use of new equipment and hygiene audits remain the cornerstones in infection control practices.
KW - acute infections
KW - hepatitis B
KW - human diseases
KW - nursing homes
KW - risk factors
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - severe infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093070303&site=ehost-live&scope=site
UR - http://www.eurosurveillance.org/images/dynamic/EE/V13N27/art18918.pdf
UR - email: gotzh@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changes in prevention and outbreak management of Legionnaires' disease in the Netherlands between two large outbreaks in 1999 and 2006.
AU - Sonder, G. J.
AU - Hoek, J. A. van den
AU - Bovée, L. P.
AU - Aanhane, F. E.
AU - Worp, J.
AU - Holle, M. du R. van B.
AU - Steenbergen, J. E. van
AU - Boer, J. W. den
AU - Ijzerman, E. P.
AU - Coutinho, R. A.
JO - Eurosurveillance
JF - Eurosurveillance
Y1 - 2008///
VL - 13
IS - 38
SP - 18983
EP - 18983
CY - Saint-Maurice; France
PB - Eurosurveillance
AD - Sonder, G. J.: Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, Netherlands.
N1 - Accession Number: 20093070345. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - We describe an outbreak of Legionnaires' disease in 2006 in Amsterdam, the Netherlands. Comparisons with the outbreak that took place in 1999 are made to evaluate changes in legionella prevention and outbreak management. The 2006 outbreak was caused by a wet cooling tower. Thirty-one patients were reported. The outbreak was detected two days after the first patient was admitted to hospital, and the source was eliminated five days later. The 1999 outbreak was caused by a whirlpool at a flower show, and 188 patients were reported. This outbreak was detected 14 days after the first patient was admitted to hospital, and two days later the source was traced. Since 1999, the awareness of legionellosis among physicians, the availability of a urinary antigen tests and more efficient early warning and communication systems improved the efficiency of legionellosis outbreak management. For prevention, extensive legislation with clear responsibilities has been put in place. For wet cooling towers, however, legislation regarding responsibility and supervision of maintenance needs to be improved.
KW - disease control
KW - epidemiology
KW - human diseases
KW - Legionnaires' disease
KW - outbreaks
KW - Netherlands
KW - Legionella
KW - man
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093070345&site=ehost-live&scope=site
UR - http://www.eurosurveillance.org/images/dynamic/EE/V13N38/art18983.pdf
UR - email: gsonder@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Bronchiolitis obliterans in workers exposed to flavoring chemicals.
AU - Kanwal, R.
A2 - Varkey, B.
T2 - Current Opinion in Pulmonary Medicine
T3 - Obstructive, occupational and environmental diseases.
JO - Current Opinion in Pulmonary Medicine
JF - Current Opinion in Pulmonary Medicine
Y1 - 2008///
VL - 14
IS - 2
SP - 141
EP - 146
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 1070-5287
AD - Kanwal, R.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H-2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083048982. Publication Type: Journal Article. Note: Obstructive, occupational and environmental diseases. Language: English. Number of References: 24 ref. Registry Number: 431-03-8. Subject Subsets: Public Health
N2 - Purpose of review: Medical and environmental surveys at microwave popcorn plants and flavoring production plants have revealed a risk for bronchiolitis obliterans in workers exposed to flavoring chemicals. Workers in other food industries may also be at risk. This review summarizes the available information on disease characteristics and natural history and provides information on workplace characteristics associated with disease development. Recent findings: Investigations carried out in flavoring plants in California have identified severely affected current and former workers in four plants. Affected former workers have also been identified at a plant in the Netherlands that manufactured diacetyl, a predominant chemical in butter flavorings which has been implicated as a causal agent for lung disease in microwave popcorn workers. Summary: Workers who manufacture or use flavorings can be subjected to repeated intense exposures to flavoring chemicals. Affected workers can progress to severe fixed airways obstruction in as little as 7 months. Since medical treatment is generally ineffective, early identification of affected workers and removal from further exposure, along with control of exposures to protect coworkers, are essential to minimize this hazard.
KW - diacetyl
KW - exposure
KW - flavour compounds
KW - flavourings
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - respiratory diseases
KW - reviews
KW - workers
KW - California
KW - Netherlands
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Benelux
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - Western Europe
KW - Europe
KW - bronchiolitis obliterans
KW - flavor compounds
KW - flavorings
KW - lung diseases
KW - United States of America
KW - Food Additives (QQ130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083048982&site=ehost-live&scope=site
UR - http://www.co-pulmonarymedicine.com
UR - email: rkanwal@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic variability of West Nile virus in US blood donors, 2002-2005.
AU - Grinev, A.
AU - Daniel, S.
AU - Stramer, S.
AU - Rossmann, S.
AU - Caglioti, S.
AU - Rios, M.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008///
VL - 14
IS - 3
SP - 436
EP - 444
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Grinev, A.: Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083069151. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - West Nile virus (WNV) was detected in the United States in 1999, has reoccurred every summer since, and has become endemic. Transfusion transmission was documented in 2002, and screening of blood donations for WNV began in 2003. We investigated genetic variation of WNV in human isolates obtained from specimens collected from 30 infected blood donors who tested positive for WNV RNA during 2002-2005. Complete genomic sequences of 8 isolates and structural gene sequences from 22 additional isolates were analyzed. We found some genetic diversity in isolates from different geographic regions and genetic divergence from reported sequences from epidemics in 1999-2001. Nucleotide divergence of structural genes showed a small increase from 2002 (0.18%) to 2005 (0.37%), suggesting absence of strong selective pressure and limited genetic evolution of WNV during that period. Nevertheless, WNV has continued to diverge from precursor isolates as geographic distribution of the virus has expanded.
KW - blood donors
KW - genetic variation
KW - human diseases
KW - nucleotide sequences
KW - strains
KW - West Nile fever
KW - USA
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - DNA sequences
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083069151&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: Maria.Rios@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ciprofloxacin-resistant Salmonella enterica serotype Typhimurium, China.
AU - Cui ShengHui
AU - Li JingYun
AU - Sun ZiYong
AU - Hu ChangQin
AU - Jin ShaoHong
AU - Guo YunChang
AU - Ran Lu
AU - Ma Yue
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008///
VL - 14
IS - 3
SP - 493
EP - 495
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Cui ShengHui: State Food and Drug Administration, Beijing, China.
N1 - Accession Number: 20083069163. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 85721-33-1. Subject Subsets: Public Health
N2 - We characterized 44 Salmonella enterica serotype Typhimurium isolates from Tongji Hospital outpatients in Wuhan, China, May 2002-October 2005. All 31 ciprofloxacin-resistant isolates were also resistant to ≥8 other antimicrobial drugs and carried ≥2 mutations in GyrA and 1 mutation in ParC. Class 1 integrons were identified in 37 isolates.
KW - ciprofloxacin
KW - drug resistance
KW - human diseases
KW - mutations
KW - resistance mechanisms
KW - salmonellosis
KW - strains
KW - man
KW - Salmonella typhimurium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Salmonella infections
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083069163&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: nicpbp@263.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Geographic linkage and variation in Cryptosporidium hominis.
AU - Chalmers, R. M.
AU - Hadfield, S. J.
AU - Jackson, C. J.
AU - Elwin, K.
AU - Xiao, L. H.
AU - Hunter, P.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008///
VL - 14
IS - 3
SP - 496
EP - 498
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Chalmers, R. M.: UK Cryptosporidium Reference Unit, National Public Health Service, Microbiology Swansea, Singleton Hospital, Swansea, SA2 8QA, Wales, UK.
N1 - Accession Number: 20083069164. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - UK Cryptosporidium hominis isolates have previously shown slight PCR fragment length polymorphism at multiple loci. To further investigate transmission, we conducted a case-control study and sequenced the GP60 locus from 115 isolates. Nine subtypes were identified; IbA10G2 predominated. Having a non-IbA10G2 subtype was significantly linked to recent travel outside Europe.
KW - genes
KW - geographical information systems
KW - nucleotide sequences
KW - strains
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - Cryptosporidium homins
KW - DNA sequences
KW - geographic information systems
KW - GIS
KW - United Kingdom
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083069164&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: rachel.chalmers@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serological survey for rabies in serum samples from vampire bats (Desmodus rotundus) in Botucatu region, SP, Brazil.
AU - Langoni, H.
AU - Souza, L. C.
AU - Zetun, C. B.
AU - Silva, T. C. C.
AU - Hoffmann, J. L.
AU - Silva, R. C.
JO - Journal of Venomous Animals and Toxins including Tropical Diseases
JF - Journal of Venomous Animals and Toxins including Tropical Diseases
Y1 - 2008///
VL - 14
IS - 4
SP - 651
EP - 659
CY - Botucatu; Brazil
PB - Center for the Study of Venoms and Venomous Animals CEVAP, UNESP
SN - 0104-7930
AD - Langoni, H.: Zoonosis Research Center, NUPEZO, Veterinary Medicine and Animal Husbandry School, São Paulo State University, UNESP, Botucatu, São Paulo State, Brazil.
N1 - Accession Number: 20093013685. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Rural Development; Animal Breeding; Tropical Diseases
N2 - The chiropterans constitute 25% of the world's mammal fauna. Due to the destruction of their natural ecosystem, the vampire bats have moved from nature to artificial roosts closer to man and domestic animals. This phenomenon has happened particularly in rural areas. Rabies is a viral anthropozoonosis, 100% lethal, and vampire bats (Desmodus rotundus) represent an important role in its epidemiology. D. rotundus were captured at night with mesh nets in partnership with the Botucatu defence Office and sent to the Zoonosis Diagnostic Service, at the School of Veterinary Medicine and Animal Husbandry, UNESP. Serum samples from 204 bats were analysed by enzyme-linked immunosorbent assay (ELISA) and fluorescent antibody viral neutralization test (FAVN) for rabies antibody detection. The results showed 7.4% of sera with titres higher or equal to 0.5 U for rabies antibodies, which demonstrated viral flow circulation among the studied region. Data suggest a need for constant monitoring accomplished by epidemiological and sanitary measures.
KW - antibody testing
KW - disease vectors
KW - ELISA
KW - human diseases
KW - monitoring
KW - neutralization tests
KW - rabies
KW - rural areas
KW - serological surveys
KW - seroprevalence
KW - veterinary medicine
KW - Brazil
KW - Sao Paulo
KW - Chiroptera
KW - Desmodus rotundus
KW - Rabies virus
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Desmodus
KW - Phyllostomidae
KW - Chiroptera
KW - Lyssavirus
KW - Rhabdoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - Brazil
KW - antibody detection
KW - antibody tests
KW - enzyme linked immunosorbent assay
KW - husbandry
KW - programmes
KW - seroepidemiology
KW - surveillance systems
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093013685&site=ehost-live&scope=site
UR - http://www.scielo.br/pdf/jvatitd/v14n4/08.pdf
UR - email: hlangoni@fmvz.unesp.br
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cadmium exposure in the South Korean population: implications of input assumptions for deterministic dietary assessment.
AU - Kim MeeHye
AU - Wolt, J. D.
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
Y1 - 2008///
VL - 14
IS - 4
SP - 835
EP - 850
CY - Boca Raton; USA
PB - Taylor & Francis
SN - 1080-7039
AD - Kim MeeHye: Korea Food and Drug Administration, National Institute of Toxicology Research, Seoul, Korea Republic.
N1 - Accession Number: 20083287076. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Registry Number: 7440-43-9. Subject Subsets: Human Nutrition; Tropical Diseases
N2 - Dietary exposure to Cadmium (Cd) is of increasing interest globally because of the adverse health effects of Cd arising from multiple sources. The assumptions used when undertaking deterministic assessment of Cd in global or regional diets have implications when applied to specific national cases representing local variation in food composition and consumption patterns different from global or regional norms. We have conducted deterministic dietary Cd exposure assessments for the South Korean population using a variety of schemes for point estimation. Consumption data from the Korean Nutrition Survey (2001 to 2003) and monitoring data from the Korea Food and Drug Administration were used as the basis for the exposure estimates. The average daily per capita Cd exposure was 14 µg for the South Korean population, representing about 27% of tolerable daily intake (TDI) and is similar to that reported in other countries. The hazard index (HI, the ratio of total Cd exposure to the TDI) typically ranged from 0.3 to 0.9 depending on assumptions used in deterministic estimates of dietary exposure. Even though the current exposure of the South Korean population at large is found to be safe on the basis of these estimates, consideration of high-end patterns of Cd level and consumption suggests the need for continued vigilance in dietary Cd monitoring.
KW - cadmium
KW - diet
KW - epidemiology
KW - exposure
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - South Korea
KW - Diet Studies (VV110)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083287076&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a795320687~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production.
AU - Elkins, C. A.
AU - Muñoz, M. E.
AU - Mullis, L. B.
AU - Stingley, R. L.
AU - Hart, M. E.
JO - Anaerobe
JF - Anaerobe
Y1 - 2008///
VL - 14
IS - 5
SP - 261
EP - 267
CY - London; UK
PB - Elsevier Ltd
SN - 1075-9964
AD - Elkins, C. A.: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA.
N1 - Accession Number: 20083322399. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - The inhibitory activities of 39 strains representing 20 different species of Lactobacillus toward a menstrual toxic shock syndrome (TSS) Staphylococcus aureus archetype strain MN8 were investigated. Nearly every strain (38 of 39) produced an inhibitory effect under both aerobic and anaerobic conditions when assayed on agar medium. In addition, the MN8 inhibition was conserved against at least 10 other clinical TSS S. aureus isolates and, interestingly, required actively growing cultures of Lactobacillus (verified with a two-well co-culture system in broth medium). This general uniform inhibition could be ameliorated by organic buffer (PIPES) supplied in the growth medium and, with only one exception, MRS medium adjusted with non-organic acid (HCl) failed to support growth of TSS strains at or below pH 5.5. By comparison, the vast majority of lactobacilli in this study decreased culture pH to a range of 4-5. Hydrogen peroxide production by the lactobacilli was also assessed and verified by two different methodologies revealing a broad spectrum of phenotypes that, contrary to reports touting its effectiveness, did not seem to correspond with our inhibition studies. Furthermore, resistances to peroxide by MN8, other TSS strains, and a subset of lactobacilli used in this study were nearly identical whereas the S. aureus collection was slightly more sensitive to racemic lactic acid than the lactobacilli. Collectively, these data suggest that the underlying inhibition toward Staphylococcus is generally conserved in Lactobacillus sp. and is related to a common factor in this genus involving promotion of acidic conditions.
KW - antibacterial properties
KW - human diseases
KW - pharmacodynamics
KW - phenotypes
KW - resistance mechanisms
KW - strains
KW - toxic shock syndrome
KW - Lactobacillus acidophilus
KW - man
KW - Staphylococcus aureus
KW - Lactobacillus
KW - Lactobacillaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - bactericidal properties
KW - bacterium
KW - drug action
KW - mechanism of drug action
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083322399&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9T-4THJGRT-1&_user=6686535&_coverDate=11%2F30%2F2008&_rdoc=4&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236691%232008%23999859994%23739128%23FLA%23display%23Volume)&_cdi=6691&_sort=d&_docanchor=&_ct=8&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=f6784a7851c5ff96c72429e230a07d90
UR - email: chris.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1).
AU - Donis, R. O.
AU - Smith, G. J. D.
AU - Perdue, M. L.
AU - Brown, I. H.
AU - Chen HuaLan
AU - Kawaoka, Y.
AU - Mackenzie, J.
AU - Shu YueLong
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008///
VL - 14
IS - 7
SP - e1
EP - e1
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Donis, R. O.: Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, OS, 330 Independence Ave SW, Room G640, Washington, DC 20201, USA.
N1 - Accession Number: 20083188604. Publication Type: Journal Article. Corporate Author: WHO/OIE/FAO H5N1 Evolution Working Group. Language: English. Number of References: 15 ref. Subject Subsets: Veterinary Science; Veterinary Science; Poultry; Public Health
N2 - Nucleotide sequences of the haemagglutinin (HA) gene of highly pathogenic avian influenza viruses (HPAI; H5N1) were collected from publicly available databases: GenBank National Center for Biotechnology and the Influenza Sequence Database of Los Alamos National Laboratories. The analysis only included nearly full-length HA sequences (i.e., at least 1600 nt in length). Multiple sequence alignment of 871 HA sequences was performed. The final alignment length was 1707 nt. Isolates with 100% sequence similarity (i.e., redundant sequences) were identified and removed, giving a final alignment of 859 sequences. Phylogenetic analyses were conducted. The study has identified 10 unique first-order numbered clades of the HPAI viruses (H5N1) in the Gs/GD-like lineage (clades 0-9). The group of HA genes previously designated as clade 2 showed a level of diversity that far exceeds the current definition of a clade; therefore, this group was also separated into 5 additional second-order clades (clades 2.1-2.5). Clades 2.1 (avian/human isolates from Indonesia) and 2.3 (avian/human isolates from the People's Republic of China; Hong Kong; Vietnam; Thailand; Lao People's Democratic Republic; and Malaysia) were also further delineated into third-order groups (clades 2.1.1-2.1.3 and 2.3.1-2.3.4), respectively. The primary clade defining factor appears to be spatio-temporal because most distinct clades consist of isolates within close geographic proximity to one another or from specific time periods (perhaps as a result of heightened transmission during outbreak periods). Notably, clade 2.2 comprises isolates from more widespread geographic areas (3 continents), which is likely to reflect movement of the virus through long-distance spread as a result of poultry trade or wild bird migration. The results from this study indicate that the HPAI H5N1 viruses can be grouped into several clades designated by a numbering system that can continue to be expanded as these viruses continue to evolve. By establishing this nomenclature system and guidelines for naming clades, this information can be used in the future as criteria for assigning new clades as new lineages of HPAI H5N1 variants emerge.
KW - animal diseases
KW - avian influenza
KW - avian influenza viruses
KW - epidemiology
KW - genes
KW - genetic variation
KW - geographical distribution
KW - human diseases
KW - influenza
KW - influenza viruses
KW - outbreaks
KW - poultry
KW - strains
KW - wild animals
KW - wild birds
KW - birds
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Avian influenzavirus
KW - bird flu
KW - bird grippe
KW - bird influenza
KW - clades
KW - domesticated birds
KW - flu
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - Influenzavirus
KW - phylognenetics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083188604&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid/content/14/7/e1.htm
UR - email: michael.perdue@hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Candidate new species of Kobuvirus in porcine hosts.
AU - Reuter, G.
AU - Boldizsár, Á.
AU - Kiss, I.
AU - Pankovics, P.
T2 - Emerging Infectious Diseases
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008///
VL - 14
IS - 12
SP - 1968
EP - 1970
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Reuter, G.: Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State, Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20093004692. Publication Type: Correspondence. Language: English. Number of References: 10 ref. Subject Subsets: Public Health; Veterinary Science; Veterinary Science; Pig Science
N2 - This study reports a new candidate species of kobuvirus. Faecal samples were collected in February 2007 from 15 healthy piglets (Sus scrofa domestica) <10 days of age from a farm in Ebes located in eastern Hungary. The aim of the study was to detect porcine calicivirus (norovirus and sapovirus) in domestic pigs by using reverse transcription-PCR (RT-PCR), using the generic primer pairs p289/p290 designed for the calicivirus RNA-dependent RNA polymerase gene (319 nt for norovirus or 331 nt for sapovirus). Two (13.3%) of 15 samples were positive for porcine sapoviruses; however, a consequent nonspecific, 1100-nt, strong, and single PCR product was found in all samples by agarose gel electrophoresis (data not shown). The nucleotide sequence of the 1065-nt nonspecific PCR product was determined. Genetic and amino acid similarity was found to be bovine (U-1) and human Aichi kobuvirus 3C (87 nt) and 3D (978 nt) regions in GenBank database by using BLAST (http://blast.ncbi.nlm.nih.gov/Blast.cgi). Nucleotide and amino acid identity of the 3C-3D regions were 73%-79% and 69%-70% to U-1 strain and Aichi virus, respectively. The phylogenetic tree confirmed that S-1-HUN belonged to kobuviruses and formed a distinct lineage.
KW - faeces
KW - genes
KW - new species
KW - nucleotide sequences
KW - phylogenetics
KW - piglets
KW - taxonomy
KW - Hungary
KW - Kobuvirus
KW - Norovirus
KW - pigs
KW - Sapovirus
KW - Vesivirus
KW - viruses
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Caliciviridae
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Calicivirus
KW - DNA sequences
KW - feces
KW - hogs
KW - swine
KW - systematics
KW - winter vomiting disease
KW - winter vomiting virus
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093004692&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid
UR - email: reuter.gabor@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay.
AU - Verma, A.
AU - Wagner, L.
AU - Stibitz, S.
AU - Nga Nguyen
AU - Guerengomba, F.
AU - Burns, D. L.
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2008///
VL - 15
IS - 11
SP - 1737
EP - 1741
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Verma, A.: Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093296948. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Public Health
N2 - The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These results demonstrate that care must be taken to ensure that LF preparations used in standardized cell-based assays are not altered at their N-terminal ends.
KW - anthrax
KW - cytotoxicity
KW - human diseases
KW - neutralization tests
KW - toxins
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093296948&site=ehost-live&scope=site
UR - http://cvi.asm.org/cgi/content/full/15/11/1737
UR - email: drusilla.burns@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An antibody modified automated enzyme-linked immunosorbent assay-based method for detection of staphylococcal enterotoxin.
AU - Bennett, R. W.
JO - Journal of Rapid Methods and Automation in Microbiology
JF - Journal of Rapid Methods and Automation in Microbiology
Y1 - 2008///
VL - 16
IS - 4
SP - 320
EP - 329
CY - Boston; USA
PB - Blackwell Publishing
SN - 1060-3999
AD - Bennett, R. W.: Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083328340. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - Studies were conducted with an automated enzyme-linked immunosorbent assay (ELISA)-based method (Vidas, Staph enterotoxin-II [SET-II]), exhibiting an antibody capture that had undergone modification by removal of the Fc fragment on the antibody. Raw liquid or shell eggs containing a nontoxin component with an attraction to the staphylococcal antienterotoxins were studied. Prior to ELISA testing, the eggs were homogenized and extracts collected by centrifugation. Studies showed that regardless of the ELISA-based method used that utilized the unmodified antibodies with both the Fab1+Fc fragments intact, positive (false positive) ELISA responses occurred with fertilized egg yolks and fertilized whole liquid or whole shell eggs. Conversely, when modified (Fab1) antibodies were used, the automated SET-II enzyme-linked fluorescent immunoassay was negative.
KW - analytical methods
KW - antibodies
KW - assays
KW - bacterial toxins
KW - eggs
KW - ELISA
KW - enterotoxins
KW - immunological techniques
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - serological techniques
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083328340&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jrm
UR - email: reginald.bennett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - State ranks of incident cancer burden due to overweight and obesity in the United States, 2003.
AU - Chang, S.
AU - Mâsse, L. C.
AU - Moser, R. P.
AU - Dodd, K. W.
AU - Arganaraz, F.
AU - Fuemmler, B. F.
AU - Jemal, A.
JO - Obesity
JF - Obesity
Y1 - 2008///
VL - 16
IS - 7
SP - 1636
EP - 1650
CY - Silver Spring; USA
PB - North American Association for the Study of Obesity (NAASO)
SN - 1930-7381
AD - Chang, S.: Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
N1 - Accession Number: 20083205452. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Public Health
N2 - Objective: Given links between obesity and cancer, we estimated incident cancer burden due to overweight and obesity at the state level in the United States. Methods and Procedures: Using state rankings by per capita burden of incident cancer cases diagnosed in 2003 that were related to overweight and obesity, we examined the frequency with which states ranked in the highest and lowest quintiles of weight-related burden for cancers of the postmenopausal breast, endometrium, kidney, colon, and prostate. In this study, data from the Behavioral Risk Factor Surveillance System (BRFSS), US Census, US Mortality Public Use Data Tapes, and National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program were used. Results: Western states had the lowest weight-related cancer burden for both sexes. Iowa, South Dakota, and West Virginia had the highest burden for all three types of male cancers. West Virginia is the only state that ranked in the quintile of highest weight-related burden for all four cancers considered in women. Discussion: For certain cancers, including endometrial, postmenopausal breast, and colon cancers, states with high burdens clustered in geographic regions, warranting further inquiry. Although state ranks for the total cancer burden and the prevalence of overweight and obesity correlated with state ranks for weight-related incident cancer burden, they often served poorly as its proxy. Such a finding cautions against simply targeting states with high overweight and obesity or high total burdens of cancers for which overweight and obesity are risk factors, as this approach may not reach areas of unrecognized burden.
KW - breast cancer
KW - carcinoma
KW - colon
KW - colon cancer
KW - disease prevalence
KW - endometrial cancer
KW - endometrium
KW - epidemiology
KW - human diseases
KW - kidney diseases
KW - neoplasms
KW - prostate
KW - prostate cancer
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - endometrial area
KW - kidney disorders
KW - nephropathy
KW - renal diseases
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083205452&site=ehost-live&scope=site
UR - http://www.nature.com/oby/journal/v16/n7/abs/oby2008228a.html
UR - email: ShineChang@MDAnderson.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adiposity measures and oxidative stress among police officers.
AU - Charles, L. E.
AU - Burchfiel, C. M.
AU - Violanti, J. M.
AU - Fekedulegn, D.
AU - Slaven, J. E.
AU - Browne, R. W.
AU - Hartley, T. A.
AU - Andrew, M. E.
JO - Obesity
JF - Obesity
Y1 - 2008///
VL - 16
IS - 11
SP - 2489
EP - 2497
CY - Silver Spring; USA
PB - North American Association for the Study of Obesity (NAASO)
SN - 1930-7381
AD - Charles, L. E.: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
N1 - Accession Number: 20083316671. Publication Type: Journal Article. Language: English. Registry Number: 50-81-7, 70-18-8, 9013-66-5. Subject Subsets: Human Nutrition
N2 - Our objective was to investigate associations between adiposity measures (BMI, waist circumference, waist-to-hip ratio, waist-to-height ratio, and abdominal height) and biomarkers of oxidative stress (glutathione (GSH), GSH peroxidase (GSH-Px), vitamin C, thiobarbituric acid reactive substances (TBARS), and trolox equivalent antioxidant capacity (TEAC)) among police officers. This cross-sectional study included randomly selected police officers (43 policewomen; 67 policemen) from Buffalo, New York. Adiposity measures were performed using standardized methods. Biomarkers were measured on fasting blood specimens. An oxidative stress score (OSS) was created as a composite of the biomarkers. ANOVAs were used to compare mean levels of biomarkers across tertiles of the adiposity measures. Officers were 26- to 61-years old. GSH was inversely associated with waist circumference (trend P=0.030) and waist-to-hip ratio (trend P=0.026). GSH-Px was inversely associated with BMI (trend P=0.004) and with waist-to-height ratio (trend P=0.017). No associations were observed for TEAC, TBARS, or OSS with any adiposity measure. Significant interactions were observed by physical activity status for GSH with waist circumference and waist-to-hip ratio and for vitamin C with waist circumference, waist-to-hip and waist-to-height ratios. The above associations were inversely related only among officers who reported engaging in physical activity. Inverse associations were observed for BMI and waist circumference with GSH, but only among women; the interaction with gender was significant. Larger indices of adiposity were associated with increased levels of oxidative stress and decreased levels of antioxidant defense.
KW - adipose tissue
KW - anthropometric dimensions
KW - antioxidants
KW - ascorbic acid
KW - body composition
KW - body fat
KW - body mass index
KW - glutathione
KW - glutathione peroxidase
KW - law enforcement
KW - oxidation
KW - physical activity
KW - sex differences
KW - New York
KW - USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anthropometric measurements
KW - police officers
KW - United States of America
KW - vitamin C
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083316671&site=ehost-live&scope=site
UR - http://www.nature.com/oby/journal/v16/n11/abs/oby2008395a.html
UR - email: lcharles@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Smoking in the home and children's health.
AU - Hill, S. C.
AU - Liang, L.
JO - Tobacco Control
JF - Tobacco Control
Y1 - 2008///
VL - 17
IS - 1
SP - 32
EP - 37
CY - London; UK
PB - BMJ Publishing Group
SN - 0964-4563
AD - Hill, S. C.: Center for Financing, Cost and Access Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Suite 5000, Rockville, MD 20850, USA.
N1 - Accession Number: 20083166917. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Objectives: We estimate for young children the annual excess health service use, healthcare expenditures, and disability bed days for respiratory conditions associated with exposure to smoking in the home in the United States. Methods: Health service use, healthcare expenditures and disability bed days data come from the 1999 and 2001 Medical Expenditure Panel Survey (MEPS). Reported smoking in the home comes from the linked National Health Interview Survey, from which the MEPS sample is drawn. Multivariate statistical analysis controls for potential confounding factors. The sample is 2759 children aged 0-4. Results: Smoking in the home is associated with an increase in the probability of emergency department visits for respiratory conditions by five percentage points and the probability of inpatient use for these conditions by three percentage points. There is no relation between indoor smoking by adults and either ambulatory visits or prescription drug expenditures. Overall, indoor smoking is associated with $117 in additional healthcare expenditures for respiratory conditions for each exposed child aged 0-4. Indoor smoking is also associated with an eight percentage point increase in the probability of having a bed day because of respiratory illness for children aged 1-4. Conclusions: Despite the significant progress made in tobacco control, many children are still exposed to secondhand smoke in their home. Reducing exposure to smoking in the home would probably reduce healthcare expenditures for respiratory conditions and improve children's health.
KW - children
KW - exposure
KW - health care costs
KW - health protection
KW - health services
KW - households
KW - human diseases
KW - respiratory diseases
KW - tobacco smoking
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083166917&site=ehost-live&scope=site
UR - http://tobaccocontrol.bmj.com/cgi/content/abstract/17/1/32
UR - email: lliang@ahrq.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.
AU - Zhang, M. D.
AU - Huang, W. Y.
AU - Andreotti, G.
AU - Gao YuTang
AU - Rashid, A.
AU - Chen, J. B.
AU - Sakoda, L. C.
AU - Shen MingChang
AU - Wang BingSheng
AU - Chanock, S.
AU - Hsing, A. W.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2008///
VL - 17
IS - 8
SP - 2123
EP - 2127
CY - Philadelphia; USA
PB - American Association for Cancer Research Inc.
SN - 1055-9965
AD - Zhang, M. D.: Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20083247705. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases
N2 - Biliary tract cancers, which encompass tumors of the gallbladder, extrahepatic ducts, and ampulla of Vater, are relatively rare tumors with a high fatality rate. Other than a close link with gallstones, the etiology of biliary tract cancers is poorly understood. We conducted a population-based case-control study in Shanghai, China, to examine whether genetic variants in several DNA repair genes are associated with biliary tract cancers or biliary stones. Genomic DNA from 410 patients with biliary tract cancers (236 gallbladder, 127 bile duct, and 47 ampulla of Vater), 891 patients with biliary stones, and 786 healthy subjects randomly selected from the Shanghai population were genotyped for putative functional single nucleotide polymorphisms in four DNA repair genes (MGMT, RAD23B, CCNH, and XRCC3). Of the five single nucleotide polymorphisms examined, only one (MGMT EX5-25C>T, rs12917) was associated with biliary tract cancer. Independent of gallstones, subjects carrying the CT genotype of the MGMT EX5-25C>T marker had a significantly reduced risk of gallbladder cancer [odds ratio (OR), 0.63; 95% confidence interval (95% CI), 0.41-0.97; P=0.02] and nonsignificant reduced risks of bile duct (OR, 0.61; 95% CI, 0.35-1.06) and ampulla of Vater (OR, 0.85; 95% CI, 0.39-1.87) cancers. However, this marker was not associated with biliary stones, and the other markers examined were not significantly associated with either biliary tract cancers or stones. Findings from this population-based study in Shanghai suggest that MGMT gene variants may alter susceptibility to biliary tract cancer, particularly gallbladder cancer. Confirmation in future studies, however, is required.
KW - cholelithiasis
KW - DNA repair
KW - genes
KW - genetic analysis
KW - human diseases
KW - neoplasms
KW - single nucleotide polymorphism
KW - China
KW - Shanghai
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Eastern China
KW - China
KW - biliary tract neoplasms
KW - cancers
KW - People's Republic of China
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083247705&site=ehost-live&scope=site
UR - http://cebp.aacrjournals.org/cgi/content/abstract/17/8/2123
UR - email: hsinga@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition policy in South Korea.
AU - Park HyeKyung
A2 - Huang, P. C.
A2 - Shiau, S. Y.
A2 - Huang, Y. S.
A2 - Huang, R. F. S.
A2 - Lee, M. S.
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
Y1 - 2008///
VL - 17
SP - 343
EP - 345
CY - Melbourne; Australia
PB - HEC Press
SN - 0964-7058
AD - Park HyeKyung: Korea Food and Drug Administration, Nutrition & Functional Food Headquarters, Nutrition Evaluation Team, #194 Tongil-ro, Eunpyung-gu, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20083125751. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 6 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology; Rural Development; Tropical Diseases
N2 - Since 1970s, the economic and social development in South Korea, as well as dietary pattern, has undergone various changes. Concerns for the decreased nutrition quality and physical activities among Koreans, especially young population, call for a need of a holistic approach in national food and nutrition policy. The National Health Promotion Act of 1995 included national interventions and programs to deal with nutrition-related chronic diseases and obesity prevention. A nation-wide monitoring system, which includes nutrition and health examination survey, is being built and run by the Ministry of Health and Welfare and its affiliated organizations every three years. The Korea Food and Drug Administration (KFDA) is another key agency undertaking national food and nutrition policies. The KFDA recently promulgated the national strategic plans for improving food safety and nutrition, focusing on children. Nutrition labelling policy for processed food is managed by KFDA and various education programs are developed and disseminated to enhance the awareness of nutrition labelling. The agency also makes standards and regulates foods for special dietary uses and health functional food. The Rural Development Administration (RDA) is responsible for maintaining the food composition database. Finally, the National School Lunch Program is mainly governed by the Ministry of Education and Human Resources De- velopment. The above central government agencies along with regional health centers are making efforts to promote the healthy eating habits in addition to constructing healthy environment by making laws and programs and by research and social marketing.
KW - food policy
KW - foods
KW - nutrition
KW - nutrition labeling
KW - nutrition policy
KW - nutrition programmes
KW - reviews
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - feeding programmes
KW - feeding programs
KW - food programs
KW - nutrition programs
KW - South Korea
KW - Food Economics (EE116) (New March 2000)
KW - Policy and Planning (EE120)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083125751&site=ehost-live&scope=site
UR - http://www.healthyeatingclub.org/APJCN/
UR - email: phkfda@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethnic, racial, and gender variations in health among farm operators in the United States.
AU - Alterman, T.
AU - Steege, A. L.
AU - Li Jia
AU - Petersen, M. R.
AU - Muntaner, C.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2008///
VL - 18
IS - 3
SP - 179
EP - 186
CY - New York; USA
PB - Elsevier
SN - 1047-2797
AD - Alterman, T.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health (MS-R17), 555 Ridge Road, Cincinnati, OH 45213, USA.
N1 - Accession Number: 20083098733. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Public Health
N2 - PURPOSE: The purpose of this study was to collect baseline prevalence data on the health problems faced by minority, white, and female farm operators. METHODS: An occupational health survey of farm operators was conducted by the U.S. Department of Agriculture, National Agricultural Statistics Service between February and August 2000. A stratified random sample of farm operators from 50 U.S. states based on the 1997 Census of Agriculture was selected for telephone interview. Interviews were primarily conducted using a computer assisted telephone instrument system. RESULTS: Population prevalences were calculated for 7137 farm operators. Prevalences were greatest for musculoskeletal discomfort, followed by respiratory problems, hearing loss, and hypertension. Generally, Latino and Asian American operators had lower prevalences for health problems than white non-Latino and white operators, respectively. African-American operators had greater prevalences for hypertension, and osteoarthritis, but lower prevalences for hearing loss, skin problems, heart problems, and cancer than white operators. American Indian or Alaska Native operators had higher prevalences for musculoskeletal problems, skin problems, and hypertension. CONCLUSIONS: Prevalences for the different ethnicity and race groups are not the same. Studies that combine racial and ethnic groups, or study only white and non-Latino farm operators may overestimate or underestimate the prevalence of health conditions in the entire farm operator population.
KW - African Americans
KW - Alaska Natives
KW - American indians
KW - Asians
KW - disease prevalence
KW - ethnic groups
KW - ethnicity
KW - farmers
KW - hearing impairment
KW - heart diseases
KW - human diseases
KW - hypertension
KW - men
KW - Mexican-Americans
KW - minorities
KW - neoplasms
KW - occupational health
KW - osteoarthritis
KW - respiratory diseases
KW - sex differences
KW - skin diseases
KW - surveys
KW - whites
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - coronary diseases
KW - dermatoses
KW - ethnic differences
KW - high blood pressure
KW - lung diseases
KW - musculoskeletal diseases
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098733&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10472797
UR - email: talterman@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US Food and Drug Administration's total diet study: dietary intake of perchlorate and iodine.
AU - Murray, C. W.
AU - Egan, S. K.
AU - Kim, H.
AU - Beru, N.
AU - Bolger, P. M.
JO - Journal of Exposure Science and Environmental Epidemiology
JF - Journal of Exposure Science and Environmental Epidemiology
Y1 - 2008///
VL - 18
IS - 6
SP - 571
EP - 580
CY - New York; USA
PB - Nature America, Inc.
SN - 1559-0631
AD - Murray, C. W.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-301, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083306590. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 7553-56-2. Subject Subsets: Public Health; Human Nutrition
N2 - The US Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) since 1961, which designed to monitor the US food supply for chemical contaminants, nutritional elements, and toxic elements. Recently, perchlorate was analyzed in TDS samples. Perchlorate is used as an oxidizing agent in rocket propellant, is found in other items (e.g., explosives, road flares, fireworks, and car airbags), occurs naturally in some fertilizers, and may be generated under certain climatic conditions. It has been detected in surface and groundwater and in food. Perchlorate at high (e.g., pharmacological) doses can interfere with iodide uptake into the thyroid gland, disrupting its function. The National Academy of Sciences (NAS) has identified that "the fetuses of pregnant women who might have hypothyroidism or iodide deficiency as the most sensitive population." This study reports on intake estimates of perchlorate and iodine, a precursor to iodide, using the analytical results from the TDS. Estimated average perchlorate and iodine daily intakes as well as the contribution of specific food groups to total intakes were estimated for 14 age/sex subgroups of the US population. The estimated smallest lower bound to the largest upper bound average perchlorate intakes by the 14 age/sex groups range from 0.08 to 0.39 micrograms per kilogram body weight per day (µg/kg bw/day), compared with the US Environmental Protection Agency (EPA) reference dose (RfD) of 0.7 µg/kg bw/day. Infants and children demonstrated the highest estimated intakes of perchlorate on a body weight basis. The estimated average iodine intakes by the 14 age/sex groups reveal a lower bound (ND=0) and upper bound (ND=LOD) range of average intakes from 138 to 353 µg/person/day. Estimated iodine intakes by infants 6-11 months exceed their adequate intake (AI), and intakes by children and adult age/sex groups exceed their relevant estimated average requirement (EAR).
KW - adults
KW - children
KW - diet
KW - food contamination
KW - food safety
KW - foods
KW - infants
KW - intake
KW - iodine
KW - perchlorates
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306590&site=ehost-live&scope=site
UR - http://www.nature.com/jes/journal/v18/n6/full/7500648a.html
UR - email: Clarence.Murray@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Racial/ethnic, socioeconomic, and behavioral determinants of childhood and adolescent obesity in the United States: analyzing independent and joint associations.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Dyck, P. C. van
AU - Siahpush, M.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2008///
VL - 18
IS - 9
SP - 682
EP - 695
CY - New York; USA
PB - Elsevier
SN - 1047-2797
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083281593. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition
N2 - PURPOSE: This study examines independent and joint associations between several socioeconomic, demographic, and behavioral characteristics and obesity prevalence among 46,707 children aged 10-17 years in the United States. METHODS: The 2003 National Survey of Children's Health was used to calculate obesity prevalence. Logistic regression was used to estimate odds of obesity and adjusted prevalence. RESULTS: Ethnic minority status, non-metropolitan residence, lower socioeconomic status (SES) and social capital, higher television viewing, and higher physical inactivity levels were all independently associated with higher obesity prevalence. Adjusted obesity prevalence varied by age, gender, race/ethnicity, and SES. Compared with affluent white children, the odds of obesity were 2.7, 1.9 and 3.2 times higher for the poor Hispanic, white, and black children, respectively. Hispanic, white, and black children watching television 3 hours or more per day had 1.8, 1.9, and 2.5 times higher odds of obesity than white children who watched television less than 1 hour/day, respectively. Poor children with a sedentary lifestyle had 3.7 times higher odds of obesity than their active, affluent counterparts (adjusted prevalence, 19.8% vs. 6.7%). CONCLUSIONS: Race/ethnicity, SES, and behavioral factors are independently related to childhood and adolescent obesity. Joint effects by gender, race/ethnicity, and SES indicate the potential for considerable reduction in the existing disparities in childhood obesity in the United States.
KW - adolescents
KW - behaviour
KW - blacks
KW - children
KW - disease prevalence
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - lifestyle
KW - obesity
KW - socioeconomic status
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - ethnic differences
KW - fatness
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281593&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10472797
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In silico toxicological screening of natural products.
AU - Arvidson, K. B.
AU - Valerio, L. G., Jr.
AU - Diaz, M.
AU - Chanderbhan, R. F.
JO - Toxicology Mechanisms and Methods
JF - Toxicology Mechanisms and Methods
Y1 - 2008///
VL - 18
IS - 2/3
SP - 229
EP - 242
CY - New York; USA
PB - Informa Healthcare
SN - 1537-6524
AD - Arvidson, K. B.: Division of Food Contact Notifications, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20093064695. Publication Type: Journal Article. Language: English. Number of References: 115 ref. Registry Number: 490-46-0, 62-46-4. Subject Subsets: Human Nutrition
N2 - This study closely examines six well-known naturally occurring dietary chemicals (estragole, pulegone, aristolochic acid I, lipoic acid, 1-octacosanol, and epicatechin) with known human exposure, chemical metabolism, and mechanism of action (MOA) using in silico screening methods. The goal of this study was to take into consideration the available information on these chemicals in terms of MOA and experimentally determined toxicological data, and compare them to the in silico predictive modeling results produced from a series of computational toxicology software. After these analyses, a consensus modeling prediction was formulated in light of the weight of evidence for each natural product. We believe this approach of examining the experimentally determined mechanistic data for a given chemical and comparing it to in silico generated predictions and data mining is a valid means to evaluating the utility of the computational software, either alone or in combination with each other. We find that consensus predictions appear to be more accurate than the use of only one or two software programs and our in silico results are in very good agreement with the experimental toxicity data for the natural products screened in this study.
KW - chemical analysis
KW - computer software
KW - epicatechin
KW - food analysis
KW - food safety
KW - metabolism
KW - mode of action
KW - phytochemicals
KW - screening
KW - techniques
KW - thioctic acid
KW - aristolochic acid
KW - computer programs
KW - estragole
KW - in silico
KW - lipoic acid
KW - octacosanol
KW - pulegone
KW - screening tests
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093064695&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a791540747~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrigenomics research for personalized nutrition and medicine.
AU - Kaput, J.
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
Y1 - 2008///
VL - 19
IS - 2
SP - 110
EP - 120
CY - London; UK
PB - Current Biology Ltd
SN - 0958-1669
AD - Kaput, J.: Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083168013. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Subject Subsets: Human Nutrition
N2 - Current nutritional and genetic epidemiological methods yield 'risk factors' on the basis of population studies. Risk factors, however, are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. These measures are often assumed to apply to individuals who are likely to differ in genetic make-up, lifestyle, and dietary patterns than to the individuals in the study population. Developing individual risk factors in light of the genetic diversity of human populations, the complexity of foods, culture and lifestyle, and the variety of metabolic processes that lead to health or disease is a significant challenge for personalizing dietary advice for healthy or individuals with chronic disease.
KW - genes
KW - genetic diversity
KW - genetic factors
KW - lifestyle
KW - mathematical models
KW - medicine
KW - nutrition research
KW - public health
KW - risk
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - medical sciences
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Nutrition (General) (VV100)
KW - Diet Studies (VV110)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083168013&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRV-4S62CGN-1&_user=6686535&_coverDate=04%2F30%2F2008&_rdoc=9&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236244%232008%23999809997%23687328%23FLA%23display%23Volume)&_cdi=6244&_sort=d&_docanchor=&_ct=20&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=978af3495b8ff614f3265bb526865bca
UR - email: James.Kaput@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid selective screening and determination of ephedrine alkaloids using GC-MS footnote mark.
AU - Ranieri, T. L.
AU - Ciolino, L. A.
JO - Phytochemical Analysis
JF - Phytochemical Analysis
Y1 - 2008///
VL - 19
IS - 2
SP - 127
EP - 135
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0958-0344
AD - Ranieri, T. L.: Forensic Chemistry Center, US Food and Drug Administration, 6751 Steger Dr., Cincinnati, OH 45231, USA.
N1 - Accession Number: 20083108996. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 299-42-3, 50-98-6, 134-72-5. Subject Subsets: Forestry; Horticultural Science
N2 - Ephedra (ma huang) has been widely used as an herb or herbal extract in both traditional Chinese medicine and Western world dietary supplements. The effects of Ephedra have been attributed to a series of six ephedrine alkaloids including ephedrine and pseudoephedrine. A GC-MS method for the ephedrine alkaloids is described which couples ammoniacal chloroform as the extraction solvent with a two-stage derivatisation scheme. This scheme produces the O-trimethylsilyl, N-trifluoracetyl derivatives (O-TMS, N-TFA) for the primary and secondary amine alkaloids, and the O-TMS derivatives for the tertiary amine alkaloids. Relatively clean extracts are obtained from complex matrices, and the six ephedrine alkaloids are effectively separated and identified. This approach was also evaluated for quantitative analysis, and was shown to provide quantitative results for ephedrine and pseudoephedrine, and good estimates for the four minor alkaloids. Figures of merit are presented for linearity, detection limits, precision and accuracy. We have applied this approach to the rapid screening and profiling of the ephedrine alkaloids in whole Ephedra plants, liquid plant extracts, dried powder plant extracts and a variety of Ephedra-containing dietary supplements.
KW - alkaloids
KW - analytical methods
KW - chemical composition
KW - diets
KW - ephedrine
KW - food supplements
KW - GC-MS
KW - plant composition
KW - screening
KW - Ephedra
KW - Ephedraceae
KW - Gnetopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - chemical constituents of plants
KW - gas chromatography-mass spectrometry
KW - screening tests
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Forests and Forest Trees (Biology and Ecology) (KK100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083108996&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com/journal/pca
UR - email: laura.ciolino@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Study of cryogenic procedures for preparation of food for element analysis.
AU - Cunningham, W. C.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2008///
VL - 21
IS - 1
SP - 35
EP - 44
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Cunningham, W. C.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Chemical Contaminants Branch (HFS-716), 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083017209. Publication Type: Journal Article. Language: English. Number of References: 20 ref.
N2 - Two cryogenic homogenization procedures, Teflon disk milling and stainless-steel impact milling, were studied for preparing food and dietary supplements for element analysis. The functionality of the disk mill was demonstrated for a fruit/nut/oatmeal granola. Improvement over a rotary cutter blending procedure was shown for three fast-food type foods - hamburger, fried chicken, and egg/ham/cheese English muffin. The capabilities of the two procedures to process mixtures comprised of very dissimilar components were compared. The mixtures included a commercial hard candy having a chili powder coating and a 50:50 (by mass) combination of choline tablets and echinacea root capsules. Nonhomogeneities were found by calculating relative standard deviations (RSDs) for replicate analyses (n=5) and comparing them with the random uncertainties associated with the measurements. Analytical portion masses ranged between 1 g and 45 mg. Element mass fractions were determined using instrumental neutron activation analysis.
KW - cryogenics
KW - food preparation
KW - food processing
KW - food supplements
KW - homogenization
KW - methodology
KW - milling
KW - methods
KW - Food Processing (General) (QQ100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083017209&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: william.cunningham@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Progress in developing analytical and label-based dietary supplement databases at the NIH Office of Dietary Supplements.
AU - Dwyer, J. T.
AU - Picciano, M. F.
AU - Betz, J. M.
AU - Fisher, K. D.
AU - Saldanha, L. G.
AU - Yetley, E. A.
AU - Coates, P. M.
AU - Milner, J. A.
AU - Whitted, J.
AU - Burt, V.
AU - Radimer, K.
AU - Wilger, J.
AU - Sharpless, K. E.
AU - Holden, J. M.
AU - Andrews, K.
AU - Roseland, J.
AU - Zhao, C. W.
AU - Schweitzer, A.
AU - Harnly, J.
AU - Wolf, W. R.
AU - Perry, C. R.
A2 - Pennington, J. A. T.
A2 - Stumbo, P. J.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2008///
VL - 21
SP - S83
EP - S93
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Dwyer, J. T.: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.
N1 - Accession Number: 20083017229. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 44 ref. Subject Subsets: Human Nutrition
N2 - Although an estimated 50% of adults in the United States consume dietary supplements, analytically substantiated data on their bioactive constituents are sparse. Several programs funded by the Office of Dietary Supplements (ODS) at the National Institutes of Health enhance dietary supplement database development and help to better describe the quantitative and qualitative contributions of dietary supplements to total dietary intakes. ODS, in collaboration with the United States Department of Agriculture, is developing a Dietary Supplement Ingredient Database (DSID) verified by chemical analysis. The products chosen initially for analytical verification are adult multivitamin-mineral supplements (MVMs). These products are widely used, analytical methods are available for determining key constituents, and a certified reference material is in development. Also MVMs have no standard scientific, regulatory, or marketplace definitions and have widely varying compositions, characteristics, and bioavailability. Furthermore, the extent to which actual amounts of vitamins and minerals in a product deviate from label values is not known. Ultimately, DSID will prove useful to professionals in permitting more accurate estimation of the contribution of dietary supplements to total dietary intakes of nutrients and better evaluation of the role of dietary supplements in promoting health and well-being. ODS is also collaborating with the National Center for Health Statistics to enhance the National Health and Nutrition Examination Survey dietary supplement label database. The newest ODS effort explores the feasibility and practicality of developing a database of all dietary supplement labels marketed in the US. This article describes these and supporting projects.
KW - databases
KW - food supplements
KW - nutrients
KW - nutritive value
KW - data banks
KW - nutritional value
KW - quality for nutrition
KW - Information and Documentation (CC300)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083017229&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: dwyerj1@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's adverse event reporting system.
AU - Chan-Tack, K. M.
AU - Struble, K. A.
AU - Birnkrant, D. B.
JO - AIDS Patient Care and STDs
JF - AIDS Patient Care and STDs
Y1 - 2008///
VL - 22
IS - 11
SP - 843
EP - 850
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
AD - Chan-Tack, K. M.: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration/OND, 10903 New Hampshire Avenue, Building 22, Room 6337, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20093004068. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 155213-67-5, 174484-41-4. Subject Subsets: Public Health
N2 - Tipranavir (TPV), a protease inhibitor, has box warnings for intracranial hemorrhage (ICH) and hepatotoxicity (including hepatic failure and death). A box warning is a labeling statement about serious adverse events leading to significant injury and/or death. A box warning is the most serious warning placed in the labeling of a prescription medication. As a result of the respective morbidity and mortality associated with ICH and hepatic failure, the Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) was searched for reports of these adverse events in HIV-infected patients receiving a tipranavir/ritonavir (TPV/r)-based regimen. This search comprised part of the FDA's safety analysis for traditional approval. From July 2006 to March 2007, 10 cases of ICH were identified in AERS. From June 2005 to March 2007, 12 cases of liver-associated deaths were identified. One patient experienced liver failure and fatal ICH. Most patients with these events had additional risk factors. Among patients with liver-associated deaths, 3 had HIV-RNA less than 400 copies per milliliter at the time of hepatic failure. Among 10 patients who discontinued TPV/r when hepatic failure developed, median number of days post-TPV/r to death was 23 (range, 2-69 days). Review of AERS did not identify new safety concerns regarding ICH. Among most patients with liver-associated deaths, death appears to occur soon after hepatic failure develops. If considering TPV/r, careful assessment of risk/benefit is suggested for patients at risk for ICH and hepatic failure.
KW - adverse effects
KW - antiviral agents
KW - drug toxicity
KW - haemorrhage
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - liver
KW - liver failure
KW - ritonavir
KW - tipranavir
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - bleeding
KW - hemorrhage
KW - human immunodeficiency virus infections
KW - intracranial hemorrhage
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093004068&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/pdfplus/10.1089/apc.2008.0043
UR - email: kirk.chan-tack@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women.
AU - Cook, J. A.
AU - Burke-Miller, J. K.
AU - Cohen, M. H.
AU - Cook, R. L.
AU - Vlahov, D.
AU - Wilson, T. E.
AU - Golub, E. T.
AU - Schwartz, R. M.
AU - Howard, A. A.
AU - Ponath, C.
AU - Plankey, M. W.
AU - Levine, A.
AU - Grey, D. D.
JO - AIDS
JF - AIDS
Y1 - 2008///
VL - 22
IS - 11
SP - 1355
EP - 1363
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Cook, J. A.: Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor St, 4th Floor M/C912, Chicago, IL 60612, USA.
N1 - Accession Number: 20083190195. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Background: Longitudinal associations between patterns of crack cocaine use and progression of HIV-1 disease are poorly understood, especially among women. This study explores relationships between crack use and HIV-1 disease outcomes in a multicenter cohort of infected women. Methods: Subjects were 1686 HIV-seropositive women enrolled at six US research centers in the Women's Interagency HIV Study. Approximately 80% were non-white and 29% used crack during the study period. Cox survival and random regression analysis examined biannual observations made April 1996 through September 2004. Outcome measures included death due to AIDS-related causes, CD4 cell count, HIV-1 RNA level, and newly acquired AIDS-defining illnesses. Results: Persistent crack users were over three times as likely as non-users to die from AIDS-related causes, controlling for use of HAART self-reported at 95% or higher adherence, problem drinking, age, race, income, education, illness duration, study site, and baseline virologic and immunologic indicators. Persistent crack users and intermittent users in active and abstinent phases showed greater CD4 cell loss and higher HIV-1 RNA levels controlling for the same covariates. Persistent and intermittent crack users were more likely than non-users to develop new AIDS-defining illnesses controlling for identical confounds. These results persisted when controlling for heroin use, tobacco smoking, depressive symptoms, hepatitis C virus coinfection, and injection drug use. Conclusion: Use of crack cocaine independently predicts AIDS-related mortality, immunologic and virologic markers of HIV-1 disease progression, and development of AIDS-defining illnesses among women.
KW - acquired immune deficiency syndrome
KW - CD4+ lymphocytes
KW - controlled substances
KW - crack
KW - disease course
KW - drug abuse
KW - drug users
KW - HIV-1 infections
KW - human diseases
KW - immunology
KW - mortality
KW - risk factors
KW - substance abuse
KW - viral diseases
KW - women
KW - California
KW - District of Columbia
KW - Illinois
KW - New York
KW - USA
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southern States of USA
KW - Corn Belt States of USA
KW - North Central States of USA
KW - East North Central States of USA
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - AIDS
KW - CD4+ cells
KW - crack cocaine
KW - death rate
KW - disease progression
KW - drug abusers
KW - drug use
KW - drugs (controlled substances)
KW - T4 lymphocytes
KW - United States of America
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083190195&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
UR - email: cook@ripco.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using mass media campaigns to promote voluntary counseling and HIV-testing services in Kenya.
AU - Marum, E.
AU - Morgan, G.
AU - Hightower, A.
AU - Ngare, C.
AU - Taegtmeyer, M.
JO - AIDS
JF - AIDS
Y1 - 2008///
VL - 22
IS - 15
SP - 2019
EP - 2024
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Marum, E.: US Department of Health and Human Services/Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, 1600 Clifton Road MS E-04, Atlanta, GA 3033, USA.
N1 - Accession Number: 20083259113. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Rural Development; Tropical Diseases
N2 - Background: Kenya, a country with high HIV prevalence, has seen a rapid scale-up of voluntary counseling and HIV-testing (VCT) services from three sites in 2000 to 585 by June 2005. From 2002 onwards, services were promoted by a four-phase professionally designed mass media campaign. Objective: To assess the impact of a mass media campaign on VCT services. Design: Observational data from client records. Methods: VCT client data from 131 voluntary counseling and testing sites were included. Descriptive statistics and Poisson regression were used to assess the impact of campaign phases. Results: Client records (381 160) from 131 sites were analyzed. A linear increase in new sites and an exponential increase in client utilization were observed. Regression analysis revealed that the first phase of the campaign increased attendance by 28.5% (95% confidence interval=15.9, 42.5%) and the fourth by 42.5% (95% confidence interval=28.4, 64.1%). These two phases, which directly mentioned HIV, had more impact on utilization than the second and third phases, which did not have a significant effect. Conclusion: The Kenyan experience suggests that a professional, intensive mass media campaign is likely to contribute to increases in utilization of testing. Expansion of programs for counseling and HIV testing in developing countries is likely to be facilitated by mass media promotion of these services.
KW - campaigns
KW - counselling
KW - disease control
KW - health services
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - mass media
KW - public health
KW - screening
KW - young adults
KW - youth
KW - Kenya
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - counseling
KW - human immunodeficiency virus infections
KW - news media
KW - screening tests
KW - Health Services (UU350)
KW - Communication and Mass Media (UU360)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083259113&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
UR - email: emarum@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HIV clinical trial design for antiretroviral development: moving forward.
AU - Chan-Tack, K. M.
AU - Struble, K. A.
AU - Morgensztejn, N.
AU - Murray, J. S.
AU - Gulick, R.
AU - Cheng, B.
AU - Weller, I.
AU - Miller, V.
JO - AIDS
JF - AIDS
Y1 - 2008///
VL - 22
IS - 18
SP - 2419
EP - 2427
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Chan-Tack, K. M.: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20083331191. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - The present review summarizes proceedings from the meeting that was convened on 10-11 January 2008 to discuss the current status and research challenges in designing studies in treatment-experienced and treatment-naive patients, and represents an overview of the views expressed. Overall, consensus was reached for many issues, including proposed approaches regarding studies in treatment-experienced patients. The main consensus was the need to design studies to minimize the risk of treatment-experienced patients receiving only one active drug in the subsequent regimen, which had been described as functional monotherapy. Different opinions are expressed regarding several aspects of treatment-naive studies, thereby providing opportunities for ongoing discussions in future workshops and larger public forums.
KW - antiviral agents
KW - clinical trials
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - reviews
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083331191&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
UR - email: vmiller@gwu.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs.
AU - Li, T. K.
A2 - Tsukamoto, H.
JO - Journal of Gastroenterology and Hepatology
JF - Journal of Gastroenterology and Hepatology
Y1 - 2008///
VL - 23
IS - Suppl. 1
SP - S2
EP - S8
CY - Melbourne; Australia
PB - Blackwell Publishing
SN - 0815-9319
AD - Li, T. K.: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA.
N1 - Accession Number: 20083155855. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - The aim of the present review was to: (i) highlight epidemiological and other studies that have generated important data on the harmful patterns of drinking that increase the risk for chronic diseases, including alcohol dependence, and on the mechanisms by which alcohol produces and, in some instances, may protect against damage; and (ii) discuss a conceptual basis for quantifying risk criteria for alcohol-induced chronic disease based on the quantity, frequency, and pattern of drinking. The relationship between heavy drinking and risk for adverse health conditions such as alcoholic liver disease (ALD), dementia, and alcohol dependence is well known. However, not everyone who drinks chronically develops ALD or dementia, and the major risk factors for disease development and the mechanisms by which this occurs have remained unclear. Large-scale, general population-based studies have provided the evidence by which quantifying the frequency of a pattern of high-risk drinking can be related directly to risk and the severity of alcohol dependence. Cellular and molecular biology studies have identified the major pathways of alcohol metabolism and how genetics and the environment can interact in some individuals to further increase the risk of organ damage. Extant databases should allow scientists and clinicians jointly to develop the framework for quantifying the drinking patterns that increase the risk of alcohol-induced organ pathologies, to develop clinical practice guidelines, such as those used to diagnose other common complex diseases (e.g. diabetes and hypertension), and to propose future studies for refining such guidelines. Attention must be paid to comorbid conditions such as hepatitis B and C infections, HIV, obesity, and environmental exposures other than alcohol. Developing trait and state biomarkers is critical to the process of discovery and to fulfilling the promise of personalized medicine.
KW - alcohol intake
KW - alcoholic beverages
KW - alcoholism
KW - dementia
KW - epidemiology
KW - human diseases
KW - liver
KW - liver diseases
KW - reviews
KW - risk factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alcohol consumption
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083155855&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jgh
UR - email: tkli@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The application of GMP certification system on health food production.
AU - Yang YongMing
AU - Liang Li
AU - Hu HaiXin
JO - Modern Food Science and Technology
JF - Modern Food Science and Technology
Y1 - 2008///
VL - 24
IS - 8
SP - 829
EP - 830, 821
CY - Guangzhou; China
PB - Editorial Board of Modern Food Science and Technology
SN - 1673-9078
AD - Yang YongMing: Guangdong food and drug administration center for evaluation & certification, Guangzhou 510080, China.
N1 - Accession Number: 20103028945. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 8 ref.
N2 - GMP supervision management system, a Delphi software derivative based on SQL Server 2000, provides a convenient link for users to check relevant information in their own database system supported by their servers. The system consists of eight modules incorporating the entire examination process. It is user-friendly; simple and practical with great potential for future extension. The system was tested for over three years at the Guangdong provincial food & drug supervision and management bureau and Guangdong provincial food & drug supervision and management bureau audition and certification center. Currently the system is being used by more than 190 health care product companies. This paper reviewed the application of this certification system in health food production.
KW - certification
KW - computer software
KW - food production
KW - food safety
KW - computer programs
KW - Information and Documentation (CC300)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103028945&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterization of tetracycline-resistant Citrobacter spp. from catfish.
AU - Nawaz, M.
AU - Khan, A. A.
AU - Khan, S.
AU - Sung, K.
AU - Steele, R.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008///
VL - 25
IS - 1
SP - 85
EP - 91
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Nawaz, M.: Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083017159. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 60-54-8, 64-75-5. Subject Subsets: Postharvest Research; Human Nutrition
N2 - Fifty-two tetracycline-resistant Citrobacter spp. strains were isolated from farm-raised catfish. Morphological and biochemical characteristics indicated that 38 of the 52 citrobacters were Citrobacter freundii, 7 were C. amalonaticus and 7 were C. braakii. All isolates were resistant to multiple antibiotics. Polymerase chain reaction (PCR) protocols were developed to detect the presence of 3 tetracycline-resistance genes (tetA, tetB and tetG) from Citrobacter isolates. Oligonucleotide primers specifically targeting a 967-bp region of tetB successfully amplified the PCR amplicons from 32/38 (85.0%) of C. freundii strains, 5/7 (71.0%) of C. amalonaticus and 4/7 (57%) from C. braakii. Oligonucleotide primers specific for the detection of tetA gene amplified the 417-bp PCR amplicons from 7/38 (18.0%) of tetracycline-resistant C. freundii only. The assay failed to amplify tetA genes from C. brakii or C. amalonaticus. Plasmids (2.0-16.0 kb) were isolated from 14 of the 38 strains of C. freundii. Strains of C. amalonaticus and C. brakii did not contain any plasmids. Dendrogram analysis of the SpeI pulsed field gel electrophoresis (PFGE) results identified 23 distinct macrorestriction patterns (mrps) among the 36 strains of C. freundii, 3 distinct mrps among the 7 strains of C. braakii and 4 unique mrps among the 7 strains of C. amalonaticus. Our results indicate that citrobacters from catfish could serve as reservoirs of tetracycline-resistance determinants.
KW - antibacterial agents
KW - drug resistance
KW - fish
KW - food contamination
KW - genes
KW - microbial contamination
KW - resistance mechanisms
KW - tetracycline
KW - Citrobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - achromycin
KW - bacterium
KW - food contaminants
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083017159&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WFP-4PBDPYJ-1-1&_cdi=6800&_user=10&_orig=browse&_coverDate=02%2F29%2F2008&_sk=999749998&view=c&wchp=dGLbVzW-zSkzV&_valck=1&md5=1cf6ab825aa410c115e495b1e58704ad&ie=/sdarticle.pdf
UR - email: mohamed.nawaz@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mathematical treatment of plates with colony counts outside the acceptable range.
AU - Blodgett, R. J.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008///
VL - 25
IS - 1
SP - 92
EP - 98
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Blodgett, R. J.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Room 2D-011, HFS-012, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083017160. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - The exclusion of plate counts outside of an acceptable range can bias the estimation of concentration. If these plates are too numerous to count (TNTC), then their microbes may be inhibited. If inhibition of the microbes on a plate is suspected, then its count may be best treated as a lower bound. When these lower bounds replace counts for some plates, the estimate and confidence interval must be calculated accordingly. Also, a measure of unusualness for plate counts is discussed.
KW - food contamination
KW - mathematical models
KW - microbial contamination
KW - plate count
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083017160&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WFP-4P9SND6-3-45&_cdi=6800&_user=10&_orig=browse&_coverDate=02%2F29%2F2008&_sk=999749998&view=c&wchp=dGLbVzW-zSkzV&_valck=1&md5=73672038ab2950e718256ce680a7dfc3&ie=/sdarticle.pdf
UR - email: robert.blodgett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mycotoxins in botanicals and dried fruits: a review.
AU - Trucksess, M. W.
AU - Scott, P. M.
A2 - Senyuva, H. Z.
A2 - Egmond, H. P. van
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 2
SP - 181
EP - 192
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Trucksess, M. W.: Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083092747. Publication Type: Journal Article; Conference paper. Language: English. Number of References: many ref. Subject Subsets: Weeds; Plant Pathology; Agroforestry; Postharvest Research; Aromatic & Medicinal Plants; Medical & Veterinary Mycology
N2 - Botanicals are used in many countries for medicinal and general health-promoting purposes. Numerous natural occurrences of mycotoxins in botanicals and dried fruits have been reported. Aflatoxins or ochratoxin A (OTA) have been found in botanicals such as ginseng, ginger, liquorice, turmeric, and kava-kava in the USA, Spain, Argentina, India, and some other countries, while fumonisins have been found in medicinal wild plants in South Africa and in herbal tea and medicinal plants in Turkey. Zearalenone was identified in ginseng root. Dried fruits can be contaminated with aflatoxins, OTA, kojic acid, and, occasionally, with patulin or zearalenone. One main area of concern is aflatoxins in dried figs; bright greenish yellow fluorescence under ultraviolet light is associated with aflatoxin contamination. OTA in dried vine fruits (raisins, sultanas, and currants) is another concern. There are also reports of aflatoxins in raisins and OTA in dried figs, apricots, dried plums (prunes), dates, and quince. Maximum permitted levels in the European Union include 4 µg kg-1 for total aflatoxins in dried fruit intended for direct consumption and 10 µg kg-1 for OTA in dried vine fruit. This review discusses the occurrence of mycotoxins in botanicals and dried fruits and analytical issues such as sampling, sample preparation, and methods for analysis. Fungal contamination of these products, the influence of sorting, storage, and processing, and prevention are also considered.
KW - aflatoxins
KW - analytical methods
KW - apricots
KW - dates
KW - dried fruit
KW - figs
KW - food contamination
KW - food hygiene
KW - food processing
KW - food safety
KW - food storage
KW - ginger
KW - liquorice
KW - mycotoxins
KW - ochratoxins
KW - plant pathogenic fungi
KW - plant pathogens
KW - plums
KW - quinces
KW - raisins
KW - reviews
KW - turmeric
KW - Curcuma longa
KW - Cydonia
KW - Cydonia oblonga
KW - Ficus
KW - Ficus carica
KW - fungi
KW - Glycyrrhiza
KW - Glycyrrhiza glabra
KW - Panax quinquefolius
KW - Phoenix dactylifera
KW - Prunus
KW - Prunus armeniaca
KW - Prunus domestica
KW - Zingiber
KW - Zingiber officinale
KW - Curcuma
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - Cydonia
KW - Moraceae
KW - Urticales
KW - Ficus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Glycyrrhiza
KW - Panax
KW - Araliaceae
KW - Apiales
KW - Phoenix
KW - Arecaceae
KW - Arecales
KW - Prunus
KW - Zingiber
KW - analytical techniques
KW - Araliales
KW - food contaminants
KW - fungal toxins
KW - fungus
KW - licorice
KW - phytopathogenic fungi
KW - phytopathogens
KW - plant-pathogenic fungi
KW - Field Crops (FF005) (New March 2000)
KW - Weeds and Noxious Plants (FF500)
KW - Food Storage and Preservation (QQ110)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083092747&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: mary.trucksess@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Blood manganese concentrations and intrauterine growth restriction.
AU - Vigeh, M.
AU - Yokoyama, K.
AU - Ramezanzadeh, F.
AU - Dahaghin, M.
AU - Fakhriazad, E.
AU - Seyedaghamiri, Z.
AU - Araki, S.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2008///
VL - 25
IS - 2
SP - 219
EP - 223
CY - New York; USA
PB - Elsevier
SN - 0890-6238
AD - Vigeh, M.: International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 21-6 Nagao 6chome, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20083137264. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 7439-96-5. Subject Subsets: Human Nutrition
N2 - To assess the relationship between blood concentrations of manganese (Mn) and intrauterine growth restriction (IUGR), Mn levels in the umbilical cord blood (UCB) and the mother whole blood (MWB) samples were measured in apparently healthy mothers and their newborns. Measurement was conducted by an inductively coupled plasma mass spectrometry. Manganese concentrations in MWB were significantly lower (p<0.01) in IUGR cases than in appropriate for gestational age (AGA) cases (mean±S.D.; 16.7±4.8 and 19.1±5.9 µg/l, respectively). Conversely, UCB concentrations of Mn were significantly higher (p<0.05) in IUGR newborns than AGA newborns (44.7±19.1 and 38.2±13.1 µg/l, respectively). Logistic regression analysis demonstrated significant relationships of the mother whole blood and the umbilical cord blood concentrations of Mn in IUGR cases (OR=0.868, 1.044, respectively). The study suggests that manganese concentrations in MWB and UCB might induce different effects on birth weight in healthy mothers. Because intrauterine growth restriction is a multi-factorial problem, further epidemiological and clinical studies on larger numbers of subjects are needed to confirm the findings in the present study.
KW - blood
KW - cord blood
KW - fetal development
KW - manganese
KW - neonates
KW - pregnancy
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - Mn
KW - newborn infants
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083137264&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TC0-4R8NB91-1&_user=6686535&_coverDate=02%2F29%2F2008&_rdoc=11&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235156%232008%23999749997%23682042%23FLA%23display%23Volume)&_cdi=5156&_sort=d&_docanchor=&_ct=21&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=eae97e632f7793a27d39cfa8a87f01ad
UR - email: vigeh@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of furan in heat processed foods by headspace gas chromatography/mass spectrometry and estimated adult exposure.
AU - Morehouse, K. M.
AU - Nyman, P. J.
AU - McNeal, T. P.
AU - DiNovi, M. J.
AU - Perfetti, G. A.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 3
SP - 259
EP - 264
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Morehouse, K. M.: Food and Drug Administration-CFSAN, 5100 Paint Branch Parkway, HFS-706, College Park, MD 20740, USA.
N1 - Accession Number: 20083092754. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Human Nutrition
N2 - Furan is a suspected human carcinogen that is formed in some processed foods at low ng per g levels. Recent improvements in analytical methodology and scientific instrumentation have made it possible to accurately measure the amount of furan in a wide variety of foods. Results from analysis of more than 300 processed foods are presented. Furan was found at levels ranging from non-detectable (LOD, 0.2-0.9 ng g-1) to over 100 ng g-1. Exposure estimates for several adult food types were calculated, with brewed coffee being the major source of furan in the adult diet (0.15 µg kg-1 body weight day-1). Estimates of mean exposure to furan for different subpopulations were calculated. For consumers 2 years and older, the intake is estimated to be about 0.2 µg kg-1 body weight day-1.
KW - adults
KW - analytical methods
KW - carcinogens
KW - coffee
KW - food consumption
KW - furans
KW - gas chromatography
KW - mass spectrometry
KW - processed products
KW - Coffea
KW - man
KW - Rubiaceae
KW - Rubiales
KW - Gentianales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - analytical techniques
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diet Studies (VV110)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083092754&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: kim.morehouse@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemical exposures at hazardous waste sites: experiences from the United States and Poland.
AU - Pohl, H. R.
AU - Tarkowski, S.
AU - Buczynska, A.
AU - Fay, M.
AU - Rosa, C. T. de
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
Y1 - 2008///
VL - 25
IS - 3
SP - 283
EP - 291
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1382-6689
AD - Pohl, H. R.: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20083243858. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Public Health
N2 - The U.S. Agency for Toxic Substances and Disease Registry (ATSDR) and the Polish Nofer Institute of Occupational Health collaborate on issues related to hazardous chemical exposure at or near hazardous waste sites. This paper outlines the scope of hazardous chemical exposure in the United States and in Poland and identifies priority chemicals and chemical mixtures. Special attention is paid to exposures to metals and to evaluation of the health risks associated with those exposures. Studies in the United States indicate that exposure to hazardous waste site chemicals may be associated with an increased risk of adverse developmental - specifically cardiovascular and neurodevelopmental - effects.
KW - exposure
KW - toxic substances
KW - toxicology
KW - Poland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - APEC countries
KW - North America
KW - America
KW - poisons
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083243858&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6D-4RDS1R1-1&_user=6686535&_coverDate=05%2F31%2F2008&_rdoc=2&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235028%232008%23999749996%23681061%23FLA%23display%23Volume)&_cdi=5028&_sort=d&_docanchor=&_ct=17&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=c4ccc25b98bd21de4b36335cc6727bdf
UR - email: hpohl@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Migration of fluorochemical paper additives from food-contact paper into foods and food simulants.
AU - Begley, T. H.
AU - Hsu, W.
AU - Noonan, G.
AU - Diachenko, G.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 3
SP - 384
EP - 390
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Begley, T. H.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20083092768. Publication Type: Journal Article. Language: English. Number of References: 16 ref.
N2 - Fluorochemical-treated paper was tested to determine the amount of migration that occurs into foods and food-simulating liquids and the characteristics of the migration. Migration characteristics of fluorochemicals from paper were examined in Miglyol, butter, water, vinegar, water-ethanol solutions, emulsions and pure oil containing small amounts of emulsifiers. Additionally, microwave popcorn and chocolate spread were used to investigate migration. Results indicate that fluorochemicals paper additives do migrate to food during actual package use. For example, we found that microwave popcorn contained 3.2 fluorochemical mg kg-1 popcorn after popping and butter contained 0.1 mg kg-1 after 40 days at 4°C. Tests also indicate that common food-simulating liquids for migration testing and package material evaluation might not provide an accurate indication of the amount of fluorochemical that actually migrates to food. Tests show that oil containing small amounts of an emulsifier can significantly enhance migration of a fluorochemical from paper.
KW - chemicals
KW - food
KW - food contamination
KW - food packaging
KW - migration
KW - packaging materials
KW - paper
KW - fluorochemicals
KW - food contaminants
KW - Food Storage and Preservation (QQ110)
KW - Food Chemistry (QQ600) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083092768&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: timothy.begley@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternal and fetal exposure to bisphenol A in Korea.
AU - Lee YoungJoo
AU - Ryu HeuiYoung
AU - Kim HyunKyung
AU - Min ChungSik
AU - Lee JinHee
AU - Kim EunHee
AU - Nam BongHyun
AU - Park JooHong
AU - Jung JinYoung
AU - Jang DongDeuk
AU - Park EunYoung
AU - Lee KwanHee
AU - Ma JinYoung
AU - Won HeySung
AU - Im MoonWhan
AU - Leem JongHan
AU - Hong YunChul
AU - Yoon HaeSeong
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2008///
VL - 25
IS - 4
SP - 413
EP - 419
CY - New York; USA
PB - Elsevier
SN - 0890-6238
AD - Lee YoungJoo: Human Exposure Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20083289539. Publication Type: Journal Article. Language: English. Number of References: 105 ref. Subject Subsets: Tropical Diseases
N2 - Bisphenol A (BPA) is a well-known endocrine disrupter used widely. Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy in Korea. This study purposed to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels to BPA in Korean pregnant women and their fetuses. Maternal blood and umbilical cord blood were collected from 300 subjects, and total BPA levels were measured. Blood BPA concentrations ranged from non-detectable to 66.48 µg/L in pregnant women and from non-detectable to 8.86 µg/L in umbilical cords. Serum BPA levels in most pregnant women were higher than in corresponding fetal umbilical cords and a positive correlation was found between in maternal and fetal BPA concentrations (p<0.05).
KW - blood
KW - cord blood
KW - exposure
KW - fetus
KW - mothers
KW - pregnancy
KW - toxic substances
KW - women
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - bisphenol A
KW - endocrine disruptors
KW - foetus
KW - gestation
KW - poisons
KW - South Korea
KW - Human Reproduction and Development (VV060)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083289539&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TC0-4SKK20B-1&_user=6686535&_coverDate=08%2F31%2F2008&_rdoc=6&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235156%232008%23999749995%23694454%23FLA%23display%23Volume)&_cdi=5156&_sort=d&_docanchor=&_ct=19&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=bc19e3e0bf1793624ee27bef1bf9a8ba
UR - email: hsyoon0956@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of epidemiology in microbial risk assessment.
AU - Miliotis, M.
AU - Dennis, S.
AU - Buchanan, R.
AU - Potter, M.
A2 - Yamamoto, S.
A2 - Voss, K. A.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 9
SP - 1052
EP - 1057
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Miliotis, M.: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20083271370. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 20 ref. Subject Subsets: Human Nutrition
N2 - Microbial risk assessment (MRA) is a systematic tool to evaluate the likelihood of exposure to food-borne pathogens and the resulting impact of exposure on consumer health. In addition, MRA can be used to evaluate the public health impact of intervention or control measures designed to prevent or reduce pathogens at any or all of the steps in our complex food production system. Epidemiological studies provide useful information and data for MRA. This paper discusses the use and limitations of epidemiological data in the development and validation of MRA using examples from published microbial risk assessments.
KW - disease prevalence
KW - epidemiology
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - public health
KW - risk assessment
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083271370&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: marianna.miliotis@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diffusion behaviour of additives in polypropylene in correlation with polymer properties.
AU - Begley, T. H.
AU - Brandsch, J.
AU - Limm, W.
AU - Siebert, H.
AU - Piringer, O.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 11
SP - 1409
EP - 1415
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Begley, T. H.: US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), College Park, Maryland, USA.
N1 - Accession Number: 20093004791. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 138-86-3, 9003-07-0.
N2 - The migration behaviour of polymer additives in 17 polypropylene (PP) samples is described. These samples cover the major types of PP used in food packaging. The diffusion coefficients of additives with relatively small molecular masses, Mr=136 (limonene), as well as the migration of typical antioxidants used in PP up to Mr=1178 (IRGANOX 1010), were measured at different temperatures. In addition, the diffusion data and percentages of xylene-soluble fractions were correlated. This enables a prediction of the migration behaviour of a PP sample by testing its 'isotactic index' with xylene. The results clearly indicate that PP can be subdivided, from the migration point of view, into the monophasic homopolymer (h-PP), the monophasic random copolymer (r-PP), and the heterophasic copolymer (heco-PP). The diffusion coefficients for r-PP are at least one order of magnitude higher than those of h-PP and comparable with the values for heco-PP. Upper limits for the diffusion values can be calculated based on the safety margin required by consumer protection laws.
KW - additives
KW - chemical properties
KW - diffusion
KW - limonene
KW - packaging materials
KW - plastics
KW - polymers
KW - polypropylenes
KW - adjuncts
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093004791&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: otto.piringer@fabes-online.de
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces.
AU - Zhang, K.
AU - Noonan, G. O.
AU - Begley, T. H.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2008///
VL - 25
IS - 11
SP - 1416
EP - 1423
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Zhang, K.: US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), College Park, Maryland, USA.
N1 - Accession Number: 20093004792. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 84-74-2, 91-20-3.
N2 - A gas chromatography-ion-trap tandem mass spectrometry procedure was developed for the determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in domestic and imported paper packages and food sold in US marketplaces. The procedure involved ultrasonic extraction with dichloromethane, followed by analysis with gas chromatography-ion-trap tandem mass spectrometry. Calibration curves for DIPN and DBP were achieved with concentrations ranging from 0.01 to 10 µg/ml and the corresponding r2 values were 0.9976 and 0.9956, respectively. In most of the fortified samples, the recoveries were higher than 80% with a relative standard deviation (RSD) <10%. Using this procedure, it was found that <20% of the tested domestic packages and >60% of the tested imported food packages contained both DIPN and DBP. The concentrations of DIPN and DBP ranged from 0.09 to 20 mg/kg and 0.14 to 55 mg/kg, respectively, with most of the DINP and DBP levels lower than 20 mg/kg. DIPN was not detected (<0.01 mg/kg) in 41 food samples, and DBP was only detected in 2 domestic and 4 imported food samples with concentrations ranging from <0.01 to 0.81 mg/kg.
KW - dibutyl phthalate
KW - food contamination
KW - food packaging
KW - food safety
KW - foods
KW - naphthalene
KW - packaging materials
KW - paper
KW - toxic substances
KW - 2,6-diisopropylnaphthalene
KW - food contaminants
KW - poisons
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093004792&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=102446
UR - email: kai.zhang@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New therapies from old medicines.
AU - Chen, S. T.
AU - Dou, J. H.
AU - Temple, R.
AU - Agarwal, R.
AU - Wu, K. M.
AU - Walker, S.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2008///
VL - 26
IS - 10
SP - 1077
EP - 1083
CY - New York; USA
PB - Nature Publishing Group
SN - 1087-0156
AD - Chen, S. T.: Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Silver Spring, MD 20993-0002, USA.
N1 - Accession Number: 20083264113. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - This article describes the current regulatory environment in the USA for botanical new drug development, summarizes the regulatory experiences, and delineates the scientific and regulatory issues involved.
KW - herbal drugs
KW - medicinal plants
KW - regulations
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083264113&site=ehost-live&scope=site
UR - http://www.nature.com/nbt/
UR - email: shaw.chen@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990-2006.
AU - Chang, S.
AU - Ball, R.
AU - Braun, M. M.
JO - Vaccine
JF - Vaccine
Y1 - 2008///
VL - 26
IS - 19
SP - 2428
EP - 2432
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Chang, S.: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM-222, Rockville, MD 20852, USA.
N1 - Accession Number: 20083142136. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - Generally, live-virus vaccines are contraindicated for pregnant women because of the theoretical risk of transmission of the vaccine virus to the fetus. Advisory groups recommend avoiding pregnancy in the immediate period after administration of such contraindicated vaccines (CVs) and stress benefit-to-risk evaluation for live or inactivated vaccines regarding pregnancy. Given the limited available data and theoretical risks associated particularly with live-virus vaccines, inadvertent immunization with CVs may lead to elective termination of pregnancy (ETP), despite advisory group statements that "vaccination is not ordinarily an indication to terminate the pregnancy." The Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance system managed by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC), accepts reports of adverse events after vaccination. The objectives of this review were to describe reports of ETP in VAERS and characterize the circumstances of inadvertent administration of vaccines to pregnant women among ETP reports. We reviewed VAERS reports of ETP submitted from 1990 to 2006. Reports of ETP for reasons other than vaccination during or shortly before pregnancy, such as fetal abnormalities or deaths, were excluded. Of 80 ETP reports, 62 (78%) originated from the US; 79 (99%) were reported by manufacturers. Median age of vaccinees was 26 years (range: 13-43 years; 67 reports). Seventy-three vaccinees (91%) received a single vaccine; 65 (81%) received at least one live-virus vaccine. In 48 (60%) ETP reports, vaccinees were unaware of pregnancy at time of immunization. In 15 (19%) reports, vaccinees became pregnant within 3 months of vaccination; in 13 (16%) reports, vaccinees might have been pregnant before vaccination; in 4 (5%) reports, information was missing. All 80 reports of ETP involved vaccines for which possible effects on fetal development are unknown. However, no cases of vaccine-associated congenital rubella or varicella syndromes have been reported in the medical literature. Also, these syndromes have not been reported to varicella or rubella vaccine pregnancy registries. VAERS has the limitations of passive surveillance systems. Under-reporting of ETP in VAERS could be substantial. More attention may be needed to assess the likelihood of pregnancy when administering vaccines to women with child-bearing potential, and to inform women who learn they are pregnant shortly after being immunized of current information on risks. Quantifying the frequency of ETP related to CVs and the risk (if any) to the fetus of such vaccines can help to inform policy, practice, and individual decision making. Good quality information may be obtained from controlled observational studies.
KW - abortion
KW - adverse effects
KW - disease transmission
KW - human diseases
KW - immunization
KW - pregnancy
KW - reviews
KW - risk factors
KW - vaccination
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - gestation
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083142136&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: soju.chang@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10-11, 2007.
AU - Eichelberger, M.
AU - Golding, H.
AU - Hess, M.
AU - Weir, J.
AU - Subbarao, K.
AU - Luke, C. J.
AU - Friede, M.
AU - Wood, D.
JO - Vaccine
JF - Vaccine
Y1 - 2008///
VL - 26
IS - 34
SP - 4299
EP - 4303
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Eichelberger, M.: US Food and Drug Administration, Center for Biologics Evaluation and Research Office of Vaccines Research and Review/Division of Viral Products, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083236298. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 5 ref. Subject Subsets: Veterinary Science; Poultry
N2 - The goals of the workshop were to identify gaps in our knowledge and abilities to address the unique challenges encountered in the development of vaccines intended to protect against pandemic influenza and to facilitate implementation of a global research agenda to improve efficacy assessment of pandemic influenza vaccines. This workshop included discussions on: (i) current knowledge regarding immune correlates of protection against seasonal influenza; (ii) human immune responses to avian influenza infection and vaccines for novel influenza viruses; (iii) limitations of currently available assays to evaluate vaccine immunogenicity; and (iv) potential insights from animal models for correlates of protection against avian influenza.
KW - animal models
KW - avian influenza
KW - avian influenza viruses
KW - immunization
KW - influenza
KW - Influenza viruses
KW - laboratory animals
KW - vaccination
KW - vaccine development
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Avian influenzavirus
KW - bird flu
KW - bird grippe
KW - bird influenza
KW - flu
KW - immune sensitization
KW - Influenzavirus
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083236298&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: hana.golding@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis.
AU - Derrick, S. C.
AU - Perera, L. P.
AU - Dheenadhayalan, V.
AU - Yang, A.
AU - Kolibab, K.
AU - Morris, S. L.
JO - Vaccine
JF - Vaccine
Y1 - 2008///
VL - 26
IS - 48
SP - 6092
EP - 6098
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Derrick, S. C.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083325533. Publication Type: Journal Article. Language: English. Number of References: 29 ref.
N2 - New post-exposure tuberculosis vaccination strategies are being developed to prevent disease in individuals latently infected with Mycobacterium tuberculosis. However, concerns about the potential induction of deleterious Koch-like reactions after immunization of persons with latent tuberculosis has limited progress in assessing the effectiveness of post-exposure vaccination. To evaluate the safety of immunization after M. tuberculosis infection, two mouse models were established, a drug treatment low bacterial burden model and an active disease model. Twelve different M. tuberculosis antigen preparations and vaccines (including DNA, subunit, viral vectored, and live, attenuated vaccines) were evaluated using these mouse models. In the low bacterial burden model, post-exposure vaccination did not induce significant reactivational disease and only injection of BCG evoked increases in lung inflammatory responses at 1 month after the immunizations. Additionally, although significant increases in lung inflammation were seen for animals injected with the hps65 DNA vaccine or a M. tuberculosis culture supernatant preparation, no differences in the survival periods were detected between vaccinated and non-vaccinated mice at 10 months post-immunization using the low bacterial burden model. For the active disease model, significantly more lung inflammation was observed at 1 month after administration of the hsp65 DNA vaccine but none of the antigen preparations tested increased the lung bacterial burdens at this early time point. Furthermore, vaccination of diseased mice with BCG or TB DNA vaccines did not significantly affect mortality rates compared to non-vaccinated controls at 10 months post-immunization. Overall, these data suggest that while the potential risk of inducing Koch-like reactions is low after immunization of persons with latent tuberculosis, extreme caution is still needed as post-exposure vaccines progress from pre-clinical experiments into the initial phases of clinical testing.
KW - animal models
KW - immunization
KW - laboratory animals
KW - vaccination
KW - vaccines
KW - mice
KW - Mycobacterium tuberculosis
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - immune sensitization
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083325533&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: steven.derrick@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicity of kava kava.
AU - Fu, P. P.
AU - Xia, Q. S.
AU - Guo, L.
AU - Yu, H. T.
AU - Chan, P. C.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2008///
VL - 26
IS - 1/4
SP - 89
EP - 112
CY - Washington; USA
PB - Taylor & Francis
SN - 1059-0501
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093054654. Publication Type: Journal Article. Language: English. Number of References: 91 ref. Subject Subsets: Aromatic & Medicinal Plants; Public Health; Human Nutrition
N2 - Kava, prepared from the rhizome of Piper methysticum, is a traditional beverage of various Pacific Basin countries. Kava has been introduced into the mainstream U.S. market principally as an anti-anxiety preparation. The effects of the long-term consumption of kava have not been documented adequately. Preliminary studies suggest possible serious organ system effects. The potential carcinogenicity of kava and its principal constituents are unknown. As such, kava extract was nominated for the chronic tumourigenicity bioassay conducted by the National Toxicology Program (NTP). At present, toxicological evaluation of kava extract is being conducted by the NTP. The present review discusses human exposure and metabolism of kava, reports recent findings on kava toxicity, and describes the mechanisms by which kava induces hepatotoxicity.
KW - beverages
KW - human diseases
KW - liver
KW - metabolism
KW - plant extracts
KW - reviews
KW - rhizomes
KW - toxicity
KW - man
KW - Piper methysticum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Piper
KW - Piperaceae
KW - Piperales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - drinks
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Physiology of Human Nutrition (VV120)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093054654&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=107845
UR - email: peter.fu@fda.hhs.gov\chanp@niehs.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Review of usnic acid and Usnea barbata toxicity.
AU - Guo, L.
AU - Shi, Q. A.
AU - Fang, J. L.
AU - Mei, N.
AU - Ali, A. A.
AU - Lewis, S. M.
AU - Leakey, J. E. A.
AU - Frankos, V. H.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2008///
VL - 26
IS - 1/4
SP - 317
EP - 338
CY - Washington; USA
PB - Taylor & Francis
SN - 1059-0501
AD - Guo, L.: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093054661. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Subject Subsets: Public Health; Human Nutrition
N2 - Usnic acid is a prominent secondary lichen metabolite that has been used for various purposes worldwide. Crude extracts of usnic acid or pure usnic acid have been marketed in the USA as dietary supplements to aid in weight loss. The US Food and Drug Administration (FDA) received 21 reports of liver toxicity related to the ingestion of dietary supplements that contain usnic acid. This prompted the FDA to issue a warning about one such supplement, LipoKinetix, in 2001 (http://www.cfsan.fda.gov/~dms/ds-lipo. html). Subsequently, usnic acid and Usnea barbata lichen were nominated by the National Toxicology Program (NTP) for toxicity evaluations. At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action.
KW - food supplements
KW - human diseases
KW - lichens
KW - liver
KW - reviews
KW - secondary metabolites
KW - toxicity
KW - USA
KW - man
KW - plants
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Parmeliaceae
KW - Lecanorales
KW - Lecanoromycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fungus
KW - United States of America
KW - Usnea
KW - Usnea barbata
KW - usnic acid
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093054661&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=107845
UR - email: lei.guo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Amoxicillin for postexposure inhalational anthrax in pediatrics: rationale for dosing recommendations.
AU - Alexander, J. J.
AU - Colangelo, P. M.
AU - Cooper, C. K.
AU - Roberts, R.
AU - Rodriguez, W. J.
AU - Murphy, M. D.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2008///
VL - 27
IS - 11
SP - 955
EP - 957
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Alexander, J. J.: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20083316927. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7. Subject Subsets: Public Health
N2 - We reviewed information about the safety and plasma pharmacokinetic data for amoxicillin, specifically related to its potential use for postexposure inhalational anthrax. Amoxicillin (45 mg/kg/d) given orally in 3 divided doses to pediatric patients <40 kg should yield an adequate time above the MIC for susceptible Bacillus anthracis (≤0.5 µg/mL) over most of the dosing interval (75-100%). Doses <45 mg/kg/d and dosing intervals longer than 8 hours should not be used for postexposure inhalational anthrax.
KW - amoxicillin
KW - anthrax
KW - antibacterial agents
KW - blood plasma
KW - chemoprophylaxis
KW - children
KW - dosage
KW - drug therapy
KW - human diseases
KW - pharmacokinetics
KW - safety
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - amoxycillin
KW - bacterium
KW - chemotherapy
KW - inhalation exposure
KW - plasma (blood)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083316927&site=ehost-live&scope=site
UR - http://www.pidj.com/
UR - email: william.rodriguez@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A Bayesian hierarchical model for the estimation of two incomplete surveillance data sets.
AU - Buenconsejo, J.
AU - Fish, D.
AU - Childs, J. E.
AU - Holford, T. R.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 2008///
VL - 27
IS - 17
SP - 3269
EP - 3285
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0277-6715
AD - Buenconsejo, J.: Center for Drugs, Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Bldg. 22, Rm. 3241, Silver Spring, MD 20993-0002, USA.
N1 - Accession Number: 20083208869. Publication Type: Journal Article. Language: English. Number of References: 61 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - A model-based approach to analyze two incomplete disease surveillance datasets is described. Such data typically consist of case counts, each originating from a specific geographical area. A Bayesian hierarchical model is proposed for estimating the total number of cases with disease while simultaneously adjusting for spatial variation. This approach explicitly accounts for model uncertainty and can make use of covariates. The method is applied to two surveillance datasets maintained by the Centers for Disease Control and Prevention on Rocky Mountain spotted fever (RMSF). An inference is drawn using Markov Chain Monte Carlo simulation techniques in a fully Bayesian framework. The central feature of the model is the ability to calculate and estimate the total number of cases and disease incidence for geographical regions where RMSF is endemic. The information generated by this model could significantly reduce the public health impact of RMSF and other vector-borne zoonoses, as well as other infectious or chronic diseases, by improving knowledge of the spatial distribution of disease risk of public health officials and medical practitioners. More accurate information on populations at high risk would focus attention and resources on specific areas, thereby reducing the morbidity and mortality caused by some of the preventable and treatable diseases.
KW - disease prevalence
KW - disease surveys
KW - epidemiological surveys
KW - epidemiology
KW - human diseases
KW - mathematical models
KW - public health
KW - Rocky Mountain spotted fever
KW - vector-borne diseases
KW - man
KW - Rickettsia rickettsii
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rickettsia
KW - Rickettsiaceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - disease surveillance
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083208869&site=ehost-live&scope=site
UR - email: Joan.Buenconsejo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multi-rule quality control for the age-related eye disease study.
AU - Caudill, S. P.
AU - Schleicher, R. L.
AU - Pirkle, J. L.
A2 - Davis, K. E.
A2 - O'Connor, K. S.
JO - Statistics in Medicine
JF - Statistics in Medicine
Y1 - 2008///
VL - 27
IS - 20
SP - 4094
EP - 4106
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0277-6715
AD - Caudill, S. P.: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA.
N1 - Accession Number: 20083236399. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 12 ref. Registry Number: 7440-66-6. Subject Subsets: Public Health
N2 - The Age-Related Eye Disease Study (AREDS), sponsored by the National Eye Institute, was designed to study the natural history and risk factors of age-related macular degeneration (AMD) and cataract, and to evaluate the effect of high doses of antioxidants and zinc on eye disease progression. AMD and cataract are leading causes of visual impairment and blindness in the U.S., with frequency of both diseases increasing dramatically after age 65. Participants were randomly chosen to receive antioxidant or placebo tablets. Blood was drawn annually from a subset of patients, and serum concentrations of 17 different nutritional indicators were measured. Because of the complexity of the analytical methods, and possibility of instrument error due to failure of any one of many component parts, several different instruments were used for most analytes. In addition, to assure that the measurement systems were performing adequately across a wide range of concentrations, multiple control pools were monitored with analyte concentrations at low, medium, and high concentrations. We report here the multi-rule quality control system (MRQCS) used during the later part of the trial (AREDS Phase III). This system was designed to monitor systematic error and random within- and among-run error for analytical runs using 1-3 different quality control pools per run and 1-2 measurements of each pool per run. We demonstrate the features of the MRQCS using quality control (QC) data associated with vitamin C measurements. We also provide operating characteristics to demonstrate how the MRQCS responds to increases in systematic and/or random error.
KW - antioxidants
KW - cataract
KW - disease course
KW - eye diseases
KW - food supplements
KW - human diseases
KW - macular degeneration
KW - quality controls
KW - risk factors
KW - statistical analysis
KW - zinc
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - disease progression
KW - maculopathy
KW - quality assurance
KW - statistical methods
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083236399&site=ehost-live&scope=site
UR - email: spc1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes.
AU - Duffy, P. H.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - Trotter, R. W.
AU - Hass, B. S.
AU - Latendresse, J. R.
AU - Thorn, B. T.
AU - Tobin, G.
AU - Feuers, R. J.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2008///
VL - 28
IS - 1
SP - 36
EP - 42
CY - New York; USA
PB - Elsevier
SN - 0271-5317
AD - Duffy, P. H.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083083642. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 9000-71-9. Subject Subsets: Dairy Science; Human Nutrition
N2 - The primary purpose of this study was to evaluate the effects of age and long-term dietary reduction on neoplastic diseases in rats fed the AIN-93M purified diet. Second, pathologic profiles are critical to comprehensive dietary evaluation. Male Sprague-Dawley rats assigned to 2 groups, ad libitum (AL) and dietary restricted (DR), were fed the AIN-93M (casein protein) diet free choice and reduced in amount by 31%, respectively. At 58 weeks of age, the predominant types of lesions in AL and DR rats were pituitary and skin tumors. At 114 weeks of age, the most common lesions were pituitary, adrenal gland, skin, mammary, brain, and pancreatic tumors and mononuclear cell leukemia. However, DR had no significant effect on these lesions. Primary findings demonstrate that DR significantly reduced the total number of tumors per rat and incidence of benign and primary tumors (all organs) but did not reduce the incidence of malignant tumors (all organs). Dietary restriction increased the percentage of unknown deaths. These results may explain why survival rates for AL and DR rats were not significantly different at 114 weeks (43.3 vs 57.5%, respectively). These findings differ from previous studies using NIH-31 cereal diet (Aging Clin Exp Res 2001;13:263; J Nutr 2002;132:101; Aging Clin Exp Res 2003;16(6):68; Aging Clin Exp Res 2004;16:448) where neoplastic lesions rather than nonneoplastic lesions were linked to a significant increase in survival rate among cohorts of DR-fed rats (J Nutr 2002;132:101). Factors such as diet composition and digestibility, although not independent of body weight, may have contributed to differences in rat mortality and may affect humans in a similar manner.
KW - animal models
KW - casein
KW - diets
KW - food restriction
KW - laboratory animals
KW - neoplasms
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083083642&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02715317
UR - email: peter.duffy@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nonneoplastic pathology in male Sprague-Dawley rats fed the American Institute of Nutrition-93M purified diet at ad libitum and dietary-restricted intakes.
AU - Duffy, P. H.
AU - Lewis, S. M.
AU - Mayhugh, M. A.
AU - Trotter, R. W.
AU - Hass, B. S.
AU - Thorn, B. T.
AU - Feuers, R. J.
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2008///
VL - 28
IS - 3
SP - 179
EP - 189
CY - New York; USA
PB - Elsevier
SN - 0271-5317
AD - Duffy, P. H.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083161677. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Human Nutrition
N2 - This study evaluates the effects of age and chronic dietary restriction (DR) on nonneoplastic diseases in rats that were fed the American Institute of Nutrition (AIN)-93M purified diet. Male Sprague-Dawley (SD) rats were divided into an ad libitum (AL) group and a DR group that was fed the AIN-93M diet with intake reduced by 31%. Nonneoplastic disease profiles were developed to clarify whether the AIN-93M diet fulfills long-term nutritional requirements of rats. Subsets of rats were killed at 58 and 114 weeks of age, and histopathology was performed. At 58 weeks of age, the 2 main types of nonneoplastic diseases in AL rats were liver vacuolization and cardiomyopathy. Dietary restriction reduced the severity and incidence of both lesions. At 114 weeks of age, the most common lesions in AL rats were cardiomyopathy, nephropathy, liver vacuolization, and degeneration with renal failure and genitourinary infections causing the greatest mortality. Dietary restriction reduced the incidence and severity of these lesions. Nonneoplastic diseases accounted for 28.9% and 0.0% of total mortalities in the AL and DR groups, respectively; however, there was a higher incidence of unknown deaths in the DR rats (52.6%) compared to AL rats (28.9%), which may have limited the success of DR to improve survival. Although the AIN-93M diet supported chronic rat growth, alterations in some dietary component concentrations may be required to lower body weight in chronic rodent and human studies. Factors such as diet composition and digestibility may alter nonneoplastic diseases and mortality in rats and humans in a similar fashion.
KW - age
KW - animal models
KW - cardiomyopathy
KW - diet
KW - digestibility
KW - disease incidence
KW - food restriction
KW - laboratory animals
KW - nutrient intake
KW - pathogenesis
KW - survival
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083161677&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02715317
UR - email: peter.duffy@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Practice-specific risk perceptions and self-reported food safety practices.
AU - Levy, A. S.
AU - Choinière, C. J.
AU - Fein, S. B.
JO - Risk Analysis
JF - Risk Analysis
Y1 - 2008///
VL - 28
IS - 3
SP - 749
EP - 761
CY - Boston; USA
PB - Blackwell Publishing
SN - 0272-4332
AD - Levy, A. S.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083199152. Publication Type: Journal Article. Language: English. Number of References: 37 ref.
N2 - The relationship between risk perception and risk avoidance is typically analyzed using self-reported measures. However, in domains such as driving or food handling, the validity of responses about usual behavior is threatened because people think about the situations in which they are self-aware, such as when they encounter a hazard. Indeed, researchers have often noted a divergence between what people say about their behavior and how they actually behave. Thus, in order to draw conclusions about risk perceptions and risk avoidance from survey data, it is important to identify particular cognitive elements, such as those measured by questions about risk and safety knowledge, risk perceptions, or information search behavior, which may be effective antecedents of self-reported safety behavior. It is also important to identify and correct for potential sources of bias that may exist in the data. The authors analyze the Food and Drug Administration's 1998 Food Safety Survey to determine whether there are consistent cognitive antecedents for three types of safe food practices: preparation, eating, and cooling of foods. An assessment of measurement biases shows that endogeneity of food choices affects reports of food preparation. In addition, response bias affects reports of cooling practices as evidenced by its relation to knowledge and information search, a pattern of cognitive effects unique to cooling practices. After correcting for these biases, results show that practice-specific risk perceptions are the primary cognitive antecedents of safe food behavior, which has implications for the design of effective education messages about food safety.
KW - attitudes
KW - behaviour
KW - cooling
KW - eating
KW - food hygiene
KW - food preparation
KW - food safety
KW - foods
KW - risk
KW - risk assessment
KW - surveys
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - United States of America
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083199152&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/risk
UR - email: conrad.choiniere@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol.
AU - Sahu, S. C.
AU - Garthoff, L. H.
AU - Robl, M. G.
AU - Chirtel, S. J.
AU - Ruggles, D. I.
AU - Flynn, T. J.
AU - Sobotka, T. J.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2008///
VL - 28
IS - 6
SP - 765
EP - 772
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0260-437X
AD - Sahu, S. C.: Division of Toxicology, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20093012013. Publication Type: Journal Article. Language: English. Registry Number: 51481-10-8. Subject Subsets: Human Nutrition; Medical & Veterinary Mycology
N2 - Deoxynivalenol (DON) is a mycotoxin food contaminant found in several cereal grains. The literature on the liver toxicity of DON in vivo is conflicting and does not clearly characterize its hepatotoxic effects. Cultured rat liver clone-9 cells were used as a model to assess the hepatotoxic potential of DON. The cell cultures, seeded onto 96-well plates, were treated at confluence with varying concentrations of DON (0-100 µg ml-1) for 48 h at 37°C in 5% CO2. After the treatment period, the cells were assayed for a number of hepatotoxic endpoints that included cytotoxicity, double-stranded DNA (ds-DNA) content, oxidative stress and mitochondrial function. The concentration-dependent toxicity of DON, as measured by cytotoxicity and ds-DNA content, was observed over the entire concentration range studied beginning at 0.5 µg ml-1. DON also induced a significant concentration-dependent increase in oxidative stress at DON concentrations starting at 10 µg ml-1. The mitochondrial function of the treated cells decreased with the increasing concentration of DON exposure, but it was not statistically different from that of the control value. Liver histopathology observed at 3, 24 and 72 h following a single intraperitoneal administration dose of DON (10 mg kg-1 BW) to adult male rats is consistent with early mild hepatotoxicity. The overall results of this study suggest that acute DON exposure has early mild cytotoxic effects on hepatocytes in vivo that are expressed as severe effects in rat liver clone-9 cells in vitro.
KW - animal models
KW - cell cultures
KW - cytotoxicity
KW - food contamination
KW - hepatotoxins
KW - laboratory animals
KW - liver
KW - liver diseases
KW - screening
KW - vomitoxin
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - deoxynivalenol
KW - food contaminants
KW - screening tests
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093012013&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/117922826/abstract
UR - email: saura.sahu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of allergic sensitization to indoor fungi in West Virginia.
AU - Beezhold, D. H.
AU - Green, B. J.
AU - Blachere, F. M.
AU - Schmechel, D.
AU - Weissman, D. N.
AU - Velickoff, D.
AU - Hogan, M. B.
AU - Wilson, N. W.
T3 - Symposium: Complications and treatment of allergic rhinitis in children.
JO - Allergy and Asthma Proceedings
JF - Allergy and Asthma Proceedings
Y1 - 2008///
VL - 29
IS - 1
SP - 29
EP - 34
CY - Providence; USA
PB - OceanSide Publications, Inc.
SN - 1088-5412
AD - Beezhold, D. H.: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
N1 - Accession Number: 20083215871. Publication Type: Journal Article. Note: Symposium: Complications and treatment of allergic rhinitis in children. Language: English. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Exposure to indoor fungi is of growing concern in residential and occupational environments in the United States. The purpose of this study was to determine the prevalence of sensitization to common indoor fungal species in an atopic population. We evaluated 102 patients (73 female and 29 male patients) for immunoglobulin E (IgE) reactivity to a panel of skin-prick test (SPT) reagents used for routine allergy testing. Patients also were tested for six additional fungi that are common indoor contaminants. All patients had symptoms consistent with allergic rhinitis or asthma. The presence of specific IgE against the fungal species was determined using immunoblotting. Of the 102 eligible patients, 68% had at least one positive skin test. The most prevalent positive SPTs were to dust mites, cats, vernal grass, and short ragweed. Overall, 21/102 (21%) patients with asthma or allergic rhinitis were skin test positive to at least one fungal extract. Of the patients with a positive SPT to fungi, 12/21 (58%) showed sensitivity to one or more of the newly tested species; most notably Trichoderma viride (8%), Chaetomium globosum (7%), Paecilomyces variotii (7%), and Acremonium strictum (6%). Immunoblotting revealed specific IgE against a number of protein bands belonging to these fungal species. The prevalence of fungal sensitization was common, particularly for indoor fungal contaminants that are not routinely included in SPT panels. Cross-reactivity with other fungi may partially explain our results; however, skin testing for these indoor fungi may provide useful diagnostic information.
KW - allergens
KW - allergies
KW - exposure
KW - human diseases
KW - rhinitis
KW - USA
KW - West Virginia
KW - Acremonium strictum
KW - Chaetomiaceae
KW - Chaetomium globosum
KW - fungi
KW - man
KW - Paecilomyces
KW - Paecilomyces variotii
KW - Trichoderma viride
KW - Acremonium
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Chaetomium
KW - Chaetomiaceae
KW - Sordariales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Paecilomyces
KW - Trichoderma
KW - Hypocreaceae
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - fungus
KW - Hyphomycetes
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083215871&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/ocean/aap/2008/00000029/00000001/art00005
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Method for estimating ultraviolet germicidal fluence rates in a hospital room.
AU - Schafer, M. P.
AU - Kujundzic, E.
AU - Moss, C. E.
AU - Miller, S. L.
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2008///
VL - 29
IS - 11
SP - 1042
EP - 1047
CY - Chicago; USA
PB - University of Chicago Press
SN - 0899-823X
AD - Schafer, M. P.: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-7, Cincinnati, OH 45226-1099, USA.
N1 - Accession Number: 20083292341. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Background. Upper-room air UV germicidal irradiation (UVGI) is an effective environmental control measure for mitigating the transmission of airborne infections. Many factors influence the efficacy of an upper-room air UVGI system, including the levels and distribution of radiation. The radiation levels experienced by airborne microorganisms can be estimated by measuring the fluence rate, which is the irradiance from all angles that is incident on a small region of space. Methods. The fluence rate can be estimated by use of a radiometer coupled to a planar detector. Measurements in 4 directions at a single point are taken and summed to estimate the fluence rate at that point. This measurement process is repeated at different sites in the room at a single height. Results. In the upper air of a test room, the UV fluence rate varied at least 3-fold, with the maximum rate occurring in the immediate vicinity of the fixtures containing lamps emitting UV radiation. In the area that would be occupied by the patient and/or healthcare personnel, no significant variation occurred in the UV fluence rate for a designated height. There was no significant statistical difference between measurements obtained by different individuals, by using a different alignment, or during 5 observation periods. Lamp failures were detected on multiple occasions. Conclusion. This method is simple, requires no specialized training, and permits regular monitoring of the necessary UV fluence rates needed to sustain the targeted airborne microorganisms' inactivation level. Additionally, this method allowed for the detection of changes in UV fluence rates in the upper air of the simulated hospital room.
KW - disease prevention
KW - hospitals
KW - nosocomial infections
KW - ultraviolet radiation
KW - antiinfective properties
KW - hospital infections
KW - Environmental Pest Management (HH200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083292341&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/591856
UR - email: mps3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Childhood overweight and obesity: is the gap closing the wrong way?
AU - Brunt, H.
AU - Lester, N.
AU - Davies, G.
AU - Williams, R.
JO - Journal of Public Health
JF - Journal of Public Health
Y1 - 2008///
VL - 30
IS - 2
SP - 145
EP - 152
CY - Oxford; UK
PB - Oxford University Press
SN - 1741-3842
AD - Brunt, H.: National Public Health Service for Wales, St. David's Park, Job's Well Road, Carmarthen SA31 3WY, UK.
N1 - Accession Number: 20083222578. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Obesity is a significant public health issue. Obese children have an increased risk of developing chronic adult diseases. Knowledge of socio-economic distribution trends in childhood overweight/obesity is limited. Methods: Body mass indices for 3-year-old children resident in three South Wales localities from 1995 to 2005 were derived from the National Community Child Health Database (NCCHD) and examined in relation to residence lower super output area (LSOA) Townsend Material Deprivation Score. Results: Over 11 years, 53-69% of children had height/weight measurements recorded (with little difference observed across deprivation fifths). Amalgamating the data for all 11 years showed no significant association of prevalence with LSOA socio-economic status. Annual trends varied substantially: the most deprived fifth had the lowest proportion on five, and the highest on six, occasions. Linear regression analysis suggested a greater rate of increase of overweight/obesity in children from most-deprived LSOA areas compared with those from least deprived areas (not statistically significant). Conclusions: Socio-economic difference in overweight/obesity prevalence lessened between 1995 and 2005. Despite annual variation, this apparent closing of the gap has been the result of an increase in overweight/obesity prevalence in children from the most deprived areas who, initially, had a lower prevalence compared with children from least deprived areas, but by 2005, had overtaken them.
KW - children
KW - epidemiology
KW - obesity
KW - overweight
KW - socioeconomic status
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - fatness
KW - prevalence
KW - United Kingdom
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083222578&site=ehost-live&scope=site
UR - http://jpubhealth.oxfordjournals.org/cgi/content/abstract/30/2/145
UR - email: huw.brunt@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559.
AU - Khan, S. A.
AU - Sung, K.
AU - Layton, S.
AU - Nawaz, M. S.
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2008///
VL - 31
IS - 1
SP - 27
EP - 36
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0924-8579
AD - Khan, S. A.: Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083038634. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 8063-07-8, 1404-90-6, 1404-93-9. Subject Subsets: Public Health
N2 - A clinical strain of Enterococcus faecium ATCC 51559 exhibits heteroresistance, i.e. a high level of resistance to vancomycin (minimum inhibitory concentration (MIC) >256 µg/mL) by broth dilution but sensitivity to vancomycin by Etest (MIC=1.8 µg/mL). Three variants of this strain, EF1, EF2 and EF3, exhibit high levels of resistance to vancomycin both by broth dilution and Etest assays. The four strains were used to study heteroresistance by pulsed-field gel electrophoresis (PFGE), polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequence analysis of a partial region of the van operon. Minor differences between SalI and SmaI restriction profiles of the variants and the parental strain were observed by PFGE analysis. PCR analysis confirmed the presence of the vancomycin resistance marker vanA (0.73 kb) and a larger than expected amplicon (8.2 kb vs. 6.7 kb) of the van operon in all the strains. The 8.2 kb van operon was cloned for EcoRI RFLP and sequence analysis. All of the clones exhibited distinctly different RFLP profiles when grown in the presence of kanamycin or vancomycin+kanamycin. The presence of these antibiotics during overnight growth of EF1 on plates also resulted in altered SalI PFGE profiles. Sequence analysis of the van operon clones revealed a 1.5 kb IS1251-like insertion element between the vanS and vanH genes in all the strains. Several novel point mutations in the vanR, vanS, vanH, vanA, vanX and vanY genes were also discovered. Some of these mutations were present in the parental strain only and included base substitutions T -> C, A -> G, T -> A and T -> C at nucleotide positions 4202, 4597, 4763 and 6207 of Tn1546, resulting in amino acid replacements I76 -> T and K208 -> E of vanR, S19 -> T of vanS and L64 -> P of vanH genes, respectively. We believe that these are responsible for the observed heteroresistance. The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin-resistant enterococci strains as a result of continuous exposure to antibiotics.
KW - antibacterial agents
KW - drug resistance
KW - genes
KW - kanamycin
KW - mutations
KW - nucleotide sequences
KW - resistance mechanisms
KW - vancomycin
KW - Enterococcus faecium
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - DNA sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083038634&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09248579
UR - email: saeed.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The pharmacogenomics of P-glycoprotein and its role in veterinary medicine.
AU - Martinez, M.
AU - Modric, S.
AU - Sharkey, M.
AU - Troutman, L.
AU - Walker, L.
AU - Mealey, K.
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
Y1 - 2008///
VL - 31
IS - 4
SP - 285
EP - 300
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0140-7783
AD - Martinez, M.: Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland, USA.
N1 - Accession Number: 20083302953. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Veterinary Science; World Agriculture, Economics & Rural Sociology; Veterinary Science
N2 - Despite advancements in pharmacogenetics in human medicine, the incorporation of pharmacogenetics into veterinary medicine is still in its early stages of development. To date, efforts to understand the pharmacologic impact of genetic variation in veterinary species have largely focused on genes encoding for the membrane transporter, P-glycoprotein (P-gp). The emphasis on the role of P-gp is largely because of safety concerns associated with the use of some macrocyclic lactones in dogs. Because of the body of information available on this topic, we use P-gp as a platform for understanding the importance of population diversity in veterinary medicine. The impact of P-gp on drug pharmacokinetics and pharmacodynamics is considered, along with endogenous and exogenous factors that can modulate P-gp activity. The review includes discussion of how population diversity in P-gp activity can lead to susceptibility to certain diseases or alter patient response to environmental stress or pharmaceutical intervention. In addition, phenotypic diversity also needs to be considered, as demonstrated by the impact of P-gp up-regulation and drug resistance. The aim of this review was to set the stage for further exploration into the impact of genetic and phenotypic variability on drug pharmacokinetics, disease propensity, product formulation and drug response in both companion and food-producing animals.
KW - drug resistance
KW - environmental degradation
KW - environmental impact
KW - genes
KW - genetic variation
KW - glycoproteins
KW - incorporation
KW - intervention
KW - lactones
KW - pharmacodynamics
KW - pharmacokinetics
KW - phenotypes
KW - phenotypic variation
KW - reviews
KW - safety
KW - susceptibility
KW - variation
KW - veterinary medicine
KW - animals
KW - dogs
KW - man
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Homo
KW - Hominidae
KW - Primates
KW - drug action
KW - environmental effects
KW - genetic variability
KW - genotypic variability
KW - genotypic variation
KW - mechanism of drug action
KW - P-glycoprotein
KW - phenotypic variability
KW - Pets and Companion Animals (LL070)
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Natural Resource Economics (EE115) (New March 2000)
KW - Natural Resources (General) (PP000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Professions: Practice and Service (CC700)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083302953&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jvp
UR - email: marilyn.martinez@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic diversity of Tn1546-like elements in clinical isolates of vancomycin-resistant enterococci.
AU - Sung, K. D.
AU - Khan, S. A.
AU - Nawaz, M. S.
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2008///
VL - 31
IS - 6
SP - 549
EP - 554
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0924-8579
AD - Sung, K. D.: Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083167641. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Registry Number: 1404-90-6, 1404-93-9. Subject Subsets: Public Health
N2 - We have investigated the genetic diversity of Tn1546 among 17 vancomycin-resistant enterococci (VRE) isolates of Enterococcus faecium. Most of these multidrug-resistant strains harboured plasmids of 2 kb to >300 kb in size. The vancomycin resistance marker vanA was located on both the plasmid and the chromosomal DNA. VRE isolates 18 and 22 failed to amplify the orf1-IRR and orf2-IRR but contained the orf1 and orf2. VRE3 failed to amplify the orf1, orf2, vanR and vanS, but still yielded a larger than expected (4.4 kb vs. 2.3 kb) vanSH amplicon. VRE9, 10, 21 and 22 also yielded larger (5.5 kb) vanSH amplicons; all others yielded 4.0 kb vanSH amplicons. Sequence analysis of the vanSH amplicons from VRE9, 10, 21 and 22 revealed the presence of IS1251 between the vanS and vanH genes in these isolates. The observed vanSH amplicon from VRE3 contained orf31, orf30 and orf29 of the plasmid pRUM followed by the vanHAXYZ region of Tn1546. Translocation of Tn1546 to a pRUM-like plasmid in VRE3 resulted in the loss of its orf1, orf2, vanR and vanS elements and a loss of the orf32 of pRUM, leading to a unique structural arrangement of vanA elements that is hitherto unknown.
KW - antibacterial agents
KW - drug resistance
KW - genes
KW - genetic diversity
KW - human diseases
KW - molecular genetics
KW - transposable elements
KW - vancomycin
KW - Enterococcus faecium
KW - man
KW - Enterococcus
KW - Enterococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - biochemical genetics
KW - DNA insertion elements
KW - insertion elements
KW - insertion sequences
KW - mobile genetic elements
KW - mobile sequences
KW - transposons
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083167641&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/09248579
UR - email: saeed.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Genetic susceptibility to progressive massive fibrosis in coal miners.
AU - Yucesoy, B.
AU - Johnson, V. J.
AU - Kissling, G. E.
AU - Fluharty, K.
AU - Kashon, M. L.
AU - Slaven, J.
AU - Germolec, D.
AU - Vallyathan, V.
AU - Luster, M. I.
T2 - European Respiratory Journal
JO - European Respiratory Journal
JF - European Respiratory Journal
Y1 - 2008///
VL - 31
IS - 6
SP - 1177
EP - 1182
CY - Sheffield; UK
PB - European Respiratory Society
SN - 0903-1936
AD - Yucesoy, B.: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention (CDC)/National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20083142148. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 76057-06-2, 308079-78-9. Subject Subsets: Public Health
N2 - Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development. The study population consisted of 648 underground coal miners participating in the National Coal Workers Autopsy Study, of which 304 were diagnosed with PMF. SNPs that influence the regulation of interleukin (IL)-1, IL-6, tumour necrosis factor-α, transforming growth factor-β1, vascular endothelial growth factor (VEGF), epidermal growth factor intercellular cell adhesion molecule (ICAM)-1 and matrix metalloproteinase-2 genes were determined using a 5′-nuclease real-time PCR assay. There were no significant differences in the distribution of any individual SNP or haplotype between the PMF and control groups. However, the polygenotype of VEGF +405/ICAM-1 +241/IL-6-174 (C-A-G) conferred an increased risk for PMF (odds ratio 3.4, 95% confidence interval 1.3-8.8). The present study suggests that the examined genetic variations that help regulate inflammatory and fibrotic processes are unlikely to strongly influence susceptibility to this interstitial lung disease, although the role of vascular endothelial growth factor, intercellular cell adhesion molecule-1 and interleukin-6 polymorphisms in the development of progressive massive fibrosis may require further investigation.
KW - fibrosis
KW - genes
KW - genetic analysis
KW - growth factors
KW - human diseases
KW - interleukin 1
KW - interleukin 6
KW - metalloproteinases
KW - miners
KW - occupational health
KW - single nucleotide polymorphism
KW - transforming growth factor
KW - tumour necrosis factor
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cachectin
KW - cachexin
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083142148&site=ehost-live&scope=site
UR - http://www.erj.ersjournals.com
UR - email: byucesoy@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking ≥48 g of alcohol per day.
AU - Signore, C.
AU - Aros, S.
AU - Morrow, J. D.
AU - Troendle, J.
AU - Conley, M. R.
AU - Flanigan, E. Y.
AU - Cassorla, F.
AU - Mills, J. L.
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
Y1 - 2008///
VL - 32
IS - 11
SP - 1893
EP - 1898
CY - Boston; USA
PB - Blackwell Publishing
SN - 0145-6008
AD - Signore, C.: Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083329174. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Registry Number: 11000-26-3. Subject Subsets: Public Health; Human Nutrition
N2 - Background: The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy. Methods: Pregnant women consuming ≥48 g alcohol per day (n=29) on average and pregnant women who abstained from alcohol use (n=39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2α, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1α (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine. Results: In crude analyses, there was no significant difference in 8-isoprostane F2α between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg creatinine, respectively, p=0.87). There were no significant differences between the drinking and nondrinking groups in levels of 2,3-dinor-6-keto-prostaglandin F1α (1.03 vs. 1.17 ng/mg creatinine, respectively, p=0.50), 11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng/mg creatinine, respectively, p=0.21), or the ratio of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p=0.14). Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not substantially alter the results. Conclusion: Our results show no difference in levels of urinary eicosanoid markers of oxidative stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant women who abstain. These findings speak against a role for maternal oxidative stress or systemic vasoconstriction in the pathogenesis of alcohol damage to the fetus.
KW - alcohol intake
KW - biochemical markers
KW - drinking
KW - oxidation
KW - pregnancy
KW - prostaglandins
KW - thromboxanes
KW - urine
KW - urine analysis
KW - vasoconstriction
KW - women
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - biomarkers
KW - drinking behaviour
KW - drinking habits
KW - gestation
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083329174&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/ACER
UR - email: MillsJ@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A multilevel analysis of state and regional disparities in childhood and adolescent obesity in the United States.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Dyck, P. C. van
JO - Journal of Community Health
JF - Journal of Community Health
Y1 - 2008///
VL - 33
IS - 2
SP - 90
EP - 102
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0094-5145
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083098853. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health
N2 - This study examines state- and regional disparities in obesity prevalence among 46,707 US children and adolescents aged 10-17 years before and after adjusting for individual socioeconomic and behavioral characteristics and area deprivation measures. The 2003 National Survey of Children's Health was used to calculate obesity prevalence in nine geographic regions and in the 50 states and the District of Columbia (DC). Logistic regression was used to estimate odds of obesity and adjusted prevalence. OLS regression was used to determine the amount of variance explained by income inequality, poverty, and violent crime rates. The prevalence of childhood obesity varied substantially across geographic areas, with the Southcentral regions of the US having the highest prevalence (≥18%) and the Mountain region the lowest prevalence (11.4%). Children in West Virginia, Kentucky, Texas, Tennessee, and North Carolina (adjusted prevalence >18.3%) had over twice the odds of being obese than their Utah counterparts (adjusted prevalence=10.4%). Geographic disparities in obesity were similar for male and female children. Individual characteristics such as race/ethnicity, household socioeconomic status, neighborhood social capital, television viewing, recreational computer use, and physical activity accounted for 55% of the state and 25% of the regional disparities in obesity. Area poverty rates accounted for an additional 18% of the state variance in adjusted obesity prevalence. Although individual and area level socioeconomic factors are important predictors, substantial geographic disparities in childhood and adolescent obesity remain. Prevention efforts targeting individual risk factors as well as contextual social and environmental factors may reduce geographic disparities in childhood and adolescent obesity.
KW - adolescents
KW - children
KW - disease prevalence
KW - epidemiology
KW - ethnicity
KW - lifestyle
KW - risk factors
KW - socioeconomic status
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098853&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=101596
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Independent and joint effects of socioeconomic, behavioral, and neighborhood characteristics on physical inactivity and activity levels among US children and adolescents.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Siahpush, M.
AU - Dyck, P. C. van
JO - Journal of Community Health
JF - Journal of Community Health
Y1 - 2008///
VL - 33
IS - 4
SP - 206
EP - 216
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0094-5145
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083197520. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health; Leisure, Recreation, Tourism
N2 - This study examines the independent and joint associations between several socioeconomic and behavioral characteristics and physical activity (PA) and inactivity prevalence among 68 288 US children aged 6-17 years. The 2003 National Survey of Children's Health was used to estimate PA prevalence. Multivariate logistic regression was used to estimate odds of activity and inactivity and adjusted prevalence, while least squares regression was used to model mean number of days of physical inactivity (PIA) in past month. The prevalence of PA varied substantially by socioeconomic and behavioral characteristics, with older, female, non-English speaking, and metropolitan children and those with lower socioeconomic status (SES) and neighborhood social capital having higher inactivity and lower activity levels. Children who watched television ≥3 h/day had 60% higher adjusted odds of PIA and 30% lower odds of PA than those who watched television <3 h/day. Children experiencing inadequate sleep during the entire week had 55% higher odds of PIA and 29% lower odds of PA than those who experienced ≥5 nights of adequate sleep during the week. Children whose both parents were physically inactive had 147% higher odds of PIA and 46% lower odds of PA than children whose parents were both physically active. Differentials in PIA by ethnicity, SES, television viewing, and parental inactivity were greater for younger than for older children. Subgroups such as older, female adolescents, children from socially disadvantaged households and neighborhoods, and those in metropolitan areas should be targeted for the promotion of regular physical activity and reduced television viewing time.
KW - adolescents
KW - attitudes
KW - attitudes to leisure
KW - behaviour
KW - children
KW - ethnicity
KW - health beliefs
KW - health promotion
KW - leisure activities
KW - neighbourhoods
KW - physical activity
KW - public health
KW - social classes
KW - socioeconomics
KW - television
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - ethnic differences
KW - neighborhoods
KW - socioeconomic aspects
KW - teenagers
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Sport and Recreational Activities (UU625) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083197520&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=101596
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multifactorial etiology of Kaposi's sarcoma: a hypothesis.
AU - Haverkos, H. W.
JO - Journal of Biosciences
JF - Journal of Biosciences
Y1 - 2008///
VL - 33
IS - 5
SP - 643
EP - 651
CY - Bangalore; India
PB - Indian Academy of Sciences
SN - 0250-5991
AD - Haverkos, H. W.: US Public Health Service, Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
N1 - Accession Number: 20093056730. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - This paper reviews the updated virological and epidemiological data on the aetiology of Kaposi's sarcoma (KS). Data linking Human herpesvirus 8 and Human immunodeficiency virus to KS are reported, including previous data on the link between nitrite inhalant abuse among gay men and KS. Epidemiological data of KS in Africa and among elderly men are also presented, as well as the possible role of vasoactive agents in the pathogenesis and physiopathology of KS.
KW - adverse effects
KW - aetiology
KW - cardiovascular agents
KW - complications
KW - disease prevalence
KW - drug therapy
KW - elderly
KW - epidemiology
KW - HIV infections
KW - homosexuality
KW - human diseases
KW - Human immunodeficiency viruses
KW - Kaposi's sarcoma
KW - men
KW - neoplasms
KW - nitrites
KW - viral diseases
KW - Human herpesvirus 8
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Rhadinovirus
KW - Gammaherpesvirinae
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - aged
KW - cancers
KW - causal agents
KW - chemotherapy
KW - elderly people
KW - etiology
KW - homosexuals
KW - human immunodeficiency virus infections
KW - older adults
KW - senior citizens
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093056730&site=ehost-live&scope=site
UR - http://www.ias.ac.in/jbiosci
UR - email: hhaverkos@usuhs.mil
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The need for public-health veterinarians as seen by future employers.
AU - Maccabe, A. T.
AU - Matchett, K. E.
AU - Hueston, W. D.
A2 - Levine, J. F.
A2 - Baker, H. J.
T3 - Issue Theme: Veterinary public health.
JO - Journal of Veterinary Medical Education
JF - Journal of Veterinary Medical Education
Y1 - 2008///
VL - 35
IS - 2
SP - 269
EP - 274
CY - Toronto; Canada
PB - University of Toronto Press Inc.
SN - 0748-321X
AD - Maccabe, A. T.: Centers for Disease Control and Prevention to the Food and Drug Administration, National Center for Zoonotic, Vectorborne, and Enteric Diseases (CDC/CCID/NCZVED), 1600 Clifton Rd, Mailstop C-09, Atlanta, GA 30039, USA.
N1 - Accession Number: 20083251936. Publication Type: Journal Article. Note: Issue Theme: Veterinary public health. Language: English. Number of References: 17 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - Future employers of veterinarians working in public health see a fast-growing demand. Emerging zoonotic diseases, bio-security threats, and food-safety problems all require the expertise of veterinarians with a focus on complex, global problems that span both human and animal health. The Public Health Task Force of the Association of American Veterinary Medical Colleges convened a group of stakeholders representing various branches of the US federal government, state and local governments, and professional societies to discuss their needs for public-health veterinarians. This article discusses those needs, the broader societal needs that require veterinarians with public-health expertise, and the implications of these for education programmes to train DVMs in public-health issues.
KW - animal diseases
KW - animal health
KW - education
KW - education programmes
KW - health
KW - public health
KW - veterinarians
KW - veterinary medicine
KW - zoonoses
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - educational programs
KW - veterinary surgeons
KW - vets
KW - zoonotic infections
KW - Animal Health and Hygiene (General) (LL800)
KW - Education, Extension, Information and Training (General) (CC000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Professions: Practice and Service (CC700)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083251936&site=ehost-live&scope=site
UR - http://www.jvmeonline.org
UR - email: amaccabe@comcast.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Outcomes for youth residential treatment programs using administrative data from the child welfare system: a risk-adjustment application.
AU - McMillen, J. C.
AU - Lee, B. R.
AU - Jonson-Reid, M.
JO - Administration and Policy in Mental Health and Mental Health Services Research
JF - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2008///
VL - 35
IS - 3
SP - 189
EP - 197
CY - Dordrecht; Netherlands
PB - Springer SBM
SN - 0894-587X
AD - McMillen, J. C.: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Campus Box 1196, St. Louis, MO 63130, USA.
N1 - Accession Number: 20083170850. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This study assessed whether administrative data from the public child welfare system could be used to develop risk-adjusted performance reports for residential mental health programs for adolescents. Regression methods were used with 3,759 residential treatment spells for 2,784 children and youth to determine which outcomes could be adequately risk adjusted for case mix. Expected outcomes were created for each residential program given its case mix; then, expected and achieved outcomes were compared. For most programs, achieved results did not differ significantly from expected results for individual outcomes. Overall, outcomes achieved were not impressive. Only one quarter of spells resulted in a youth being maintained in a single less restrictive setting in the year following discharge. Methodological implications of this study suggest further refinements are needed for child welfare administrative data in order to develop risk-adjusted report cards of program performance.
KW - adolescents
KW - child welfare
KW - children
KW - medical treatment
KW - mental disorders
KW - mental health
KW - welfare services
KW - youth
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - mental illness
KW - psychiatric disorders
KW - teenagers
KW - Public Services and Infrastructure (UU300)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083170850&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/h8p711h005307500/?p=0b38cbd255ef4e5f8e08cde825073d2d&pi=5
UR - email: cmcmille@wustl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quality assurance and improvement practice in mental health agencies: roles, activities, targets and contributions.
AU - McMillen, C.
AU - Zayas, L. E.
AU - Books, S.
AU - Lee, M.
JO - Administration and Policy in Mental Health and Mental Health Services Research
JF - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2008///
VL - 35
IS - 6
SP - 458
EP - 467
CY - Dordrecht; Netherlands
PB - Springer SBM
SN - 0894-587X
AD - McMillen, C.: Center for Mental Health Services Research George Warren Brown School of Social Work, Washington University in St. Louis, Washington University Campus Box 1196, One Brookings Drive, St. Louis, MO 63130, USA.
N1 - Accession Number: 20083292435. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Accompanying the rise in the number of mental health agency personnel tasked with quality assurance and improvement (QA/I) responsibilities is an increased need to understand the nature of the work these professionals undertake. Four aspects of the work of quality assurance and improvement (QA/I) professionals in mental health were explored in this qualitative study: their perceived roles, their major activities, their QA/I targets, and their contributions. In-person interviews were conducted with QA/I professionals at 16 mental health agencies. Respondents perceived their roles at varying levels of complexity, focused on different targets, and used different methods to conduct their work. Few targets of QA/I work served as indicators of high quality care. Most QA/I professionals provided concrete descriptions of how they had improved agency services, while others could describe none. Accreditation framed much of agency QA/I work, perhaps to its detriment.
KW - health care
KW - health services
KW - mental health
KW - personnel
KW - psychiatric services
KW - quality controls
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - employees
KW - quality assurance
KW - staff
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083292435&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/324j048128102037/?p=68932a289ff5410e8c883135e93def80&pi=3
UR - email: cmcmille@wustl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the rationale for concurrent use of N95 filtering facepiece respirators with loose-fitting powered air-purifying respirators during aerosol-generating medical procedures.
AU - Roberge, R. J.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2008///
VL - 36
IS - 2
SP - 135
EP - 141
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Roberge, R. J.: National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA.
N1 - Accession Number: 20083068749. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Public Health
N2 - The concurrent use of N95 filtering facepiece respirators with powered air-purifying respirators during aerosol-generating medical procedures in patients with severe respiratory pathogens has been promoted as offering additional protection against infectious agents. The purpose of this article is to examine the impact of this additional respiratory equipment upon protection and personal performance. The presumed additive protective effect of an N95 filtering facepiece respirator used concurrently with a powered air-purifying respirator has not been subjected to rigorous scientific investigation. The burden imposed by additional respiratory protective equipment should not be discounted, and the potentially minor contribution to protection may be offset by the negative impact on personal performance. Novel uses of protective equipment occasionally are spawned during crisis situations, but their generalized applicability to healthcare workers should ultimately be evidence-based.
KW - aerosols
KW - exposure
KW - health care workers
KW - health protection
KW - human diseases
KW - infectious diseases
KW - occupational hazards
KW - occupational health
KW - protective clothing
KW - respiratory diseases
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - air purifying respirators
KW - communicable diseases
KW - lung diseases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083068749&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4RY6SWC-G&_user=6686535&_coverDate=03%2F31%2F2008&_rdoc=14&_fmt=full&_orig=browse&_srch=doc-info(%23toc%236686%232008%23999639997%23681791%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=18&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=98b6d40c76352c93198f0e11cdcafffe
UR - email: dtn0@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Perceived psychosocial job stress and sleep bruxism among male and female workers.
AU - Nakata, A.
AU - Takahashi, M.
AU - Ikeda, T.
AU - Hojou, M.
AU - Araki, S.
JO - Community Dentistry and Oral Epidemiology
JF - Community Dentistry and Oral Epidemiology
Y1 - 2008///
VL - 36
IS - 3
SP - 201
EP - 209
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0301-5661
AD - Nakata, A.: Division of Applied Research and Technology, MS-C24, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083160330. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Public Health
N2 - Objective: Psychosocial job stress has been associated with sleep disturbances, but its association with sleep bruxism (SB), the stereotype movement disorder related to sleep, is not well understood. The aim of this epidemiological study was to examine the relationship between psychosocial job stress and SB. Methods: 1944 male and 736 female factory workers participated in this study (response rate 78.1%). Perceived job stress was evaluated with the Japanese version of the generic job stress questionnaire, which covered 13 job stress variables. SB was assessed by the question, 'Do you grind or clench your teeth during your sleep or has anyone in your family told you that you grind your teeth during your sleep?' Response options were 'never', 'seldom', 'sometimes' or 'often'. SB was considered present if the answer was 'sometimes' or 'often'. Results: Overall, 30.9% of males and 20.2% of females reported SB. In males, workers with low social support from supervisors [odds ratio (OR)=1.34, 95% confidence interval (CI) 1.08-1.68] or from colleagues (OR 1.47, 95% CI 1.17-1.83), and high depressive symptoms (OR 1.60, 95% CI 1.26-2.03) had a significantly increased risk of SB after controlling for confounders. By contrast, no significant association was found in females. Conclusions: We conclude that SB is weakly associated with some aspects of job stress in men but not in women among the Japanese working population.
KW - attitudes
KW - depression
KW - epidemiology
KW - factory workers
KW - human diseases
KW - occupational health
KW - personal support networks
KW - psychosocial aspects
KW - sex differences
KW - sleep
KW - work stress
KW - workers
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083160330&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/com
UR - email: nakataa-tky@umin.ac.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National Healthcare Safety Network (NHSN) Report, data summary for 2006 through 2007, issued November 2008.
AU - Edwards, J. R.
AU - Peterson, K. D.
AU - Andrus, M. L.
AU - Dudeck, M. A.
AU - Pollock, D. A.
AU - Horan, T. C.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2008///
VL - 36
IS - 9
SP - 609
EP - 626
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Edwards, J. R.: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20083292422. Publication Type: Journal Article. Corporate Author: USA, National Healthcare Safety Network Facilities Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This report is a summary of device-associated and procedure-associated module data collected and reported by hospitals participating in the National Healthcare Safety Network (NHSN) from January 2006 through December 2007 as reported to the NHSN by 24 March 2008. This report updates previously published device-associated module data from NHSN and surgical site infection rate data from the National Nosocomial Infections Surveillance system.
KW - epidemiology
KW - human diseases
KW - nosocomial infections
KW - surveillance
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - hospital infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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UR - email: jredwards@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of health care personnel needs for training in infection control: one size does not fit all.
AU - Knapp, M. B.
AU - McIntyre, R.
AU - Sinkowitz-Cochran, R. L.
AU - Pearson, M. L.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2008///
VL - 36
IS - 10
SP - 757
EP - 760
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Knapp, M. B.: Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20083329615. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - To guide development of infection control education, we conducted a pilot needs assessment to determine current infection control knowledge, identify potential gaps between knowledge and practice, and identify perceived training needs among a varied group of health care personnel. A total of 23 health care personnel from various disciplines and health care settings completed the self-administered Web-based survey. Differences in knowledge and self-identified training needs were found among disciplines. Future research may well focus on further exploring specific needs of different disciplines. These results will be used to inform topics to cover in infection control curricula for clinicians, public health professionals, and allied health personnel.
KW - disease control
KW - disease prevention
KW - health care
KW - health care workers
KW - human diseases
KW - infectious diseases
KW - public health
KW - training
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - Education and Training (CC100)
KW - Pathogen, Pest, Parasite and Weed Management (General) (HH000)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
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UR - email: rls7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Making use of electronic data: the National Healthcare Safety Network eSurveillance Initiative.
AU - Edwards, J. R.
AU - Pollock, D. A.
AU - Kupronis, B. A.
AU - Li, W. K.
AU - Tolson, J. S.
AU - Peterson, K. D.
AU - Mincey, R. B.
AU - Horan, T. C.
A2 - Olmsted, R. N.
A2 - Wright, M. O.
T3 - Informatics and infection prevention and control: are we there yet?
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2008///
VL - 36
IS - 3, Suppl. 1
SP - S21
EP - S26
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Edwards, J. R.: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20083145809. Publication Type: Journal Article. Note: Informatics and infection prevention and control: are we there yet? Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - Efforts are underway at the Centers for Disease Control and Prevention to foster greater use of electronic data stored in health care application databases for surveillance of health care-associated infections and antimicrobial use and resistance. These efforts, referred to as the National Healthcare Safety Network (NHSN) eSurveillance Initiative, focus on standards-based solutions for conveying health care data and validation processes to confirm that the data received at the Centers for Disease Control and Prevention accurately reflect the data transmitted by health care facilities. Standard vehicles for data transmission, specifically Health Level Seven standards for electronic messages and structured documents, and standard vocabularies for representing microorganisms and other information needed for surveillance, are central features of the eSurveillance Initiative. Progress to date in this initiative is reviewed, and future project plans are outlined. Enhanced interoperability between health care and public health information systems is achievable for surveillance purposes, but major challenges must be overcome to realize the full benefits sought by the eSurveillance Initiative.
KW - antiinfective agents
KW - data collection
KW - databases
KW - drug resistance
KW - drug therapy
KW - health care
KW - human diseases
KW - infection control
KW - infectious diseases
KW - nosocomial infections
KW - public health
KW - reviews
KW - surveillance
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - chemotherapy
KW - communicable diseases
KW - data banks
KW - data logging
KW - hospital infections
KW - Information and Documentation (CC300)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083145809&site=ehost-live&scope=site
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UR - email: jredwards@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An investigation of hand forces and postures for using selected mechanical pipettes.
AU - Lu, M. L.
AU - James, T.
AU - Lowe, B.
AU - Barrero, M.
AU - Kong YongKu
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008///
VL - 38
IS - 1
SP - 18
EP - 29
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Lu, M. L.: National Institute for Occupational Safety and Health, Taft Laboratories, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083084445. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Public Health
N2 - The present study evaluated thumb, hand forces, wrist, forearm and shoulder postures used for pipetting with three selected mechanical pipettes. Twelve pipette users in a large university health system participated in pipetting simulation in their own laboratories to investigate the effects of pipette type, body posture (standing/seated), sample volume (200/1000 µL) and pipetting task on the physical risk factors. The thumb and hand forces were measured with 19 FlexiforceTM sensors. Wrist and forearm postures were measured with an electrogoniometer and a torsiometer, respectively. Humeral elevation as shoulder postural stress was assessed by observations from videos recorded during pipetting simulation. The study results showed several advantages of using the non-axial pipette over the traditional axial ones. The non-axial pipette was associated with approximately 2-6 times less thumb and hand force than the traditional axial pipettes. In addition, there were approximately 20-30% reductions in ulnar deviation and 30-70% reductions in humeral elevation to operate the non-axial pipette for most of the pipetting actions. One disadvantage of using the non-axial pipette appears to be increased forearm pronation by approximately 100-150% for the entire pipetting cycle, as compared to the axial pipettes. The results of the study may provide useful information regarding design of pipettes for reducing physical risk factors associated with pipetting. Relevance to industry: This paper demonstrated hand forces and postures for common pipetting tasks with selected mechanical pipettes. The hand force and postural data for using axial and non-axial pipettes may provide key information for hand injury prevention due to pipetting in the industry.
KW - ergonomics
KW - laboratories
KW - laboratory equipment
KW - operator comfort
KW - Occidryas
KW - Nymphalidae
KW - Lepidoptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - human engineering
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083084445&site=ehost-live&scope=site
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UR - email: mlu@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of subjective responses to whole-body vibration exposure: effect of frequency content.
AU - Maeda, S.
AU - Mansfield, N. J.
AU - Shibata, N.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008///
VL - 38
IS - 5/6
SP - 509
EP - 515
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Maeda, S.: Measurement and Control of Work Environment Research Group, Japan National Institute of Occupational Safety and Health (JNIOSH), Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20083237171. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Agricultural Engineering; Public Health
N2 - The relationship between the subjective ride comfort in a vehicle seat and whole-body vibration can be modeled using frequency weightings and rms averaging as specified in ISO 2631-1. If two vibrating environments have the same frequency-weighted rms acceleration value using this method, it is assumed that the two environments would have the same degree of discomfort. In recent years, it has been found that when subjects are exposed to random whole-body vibration, even with the same frequency-weighted rms acceleration signals according to the ISO 2631-1 standard which consists of different frequency spectra will elicit different degree of comfort. From the viewpoint of this result, it is doubtful whether frequency-weighting based on ISO 2631-1 is appropriate for such vibrations. In this paper, the alternative approach which Miwa's proposed VG method modified was examined. The following conclusion was suggested: VGt value which was obtained by the alternative approach seems to be appropriate from random vibrations which have same frequency-weighted rms acceleration with different frequency components. The alternative approach based on the VG method has wider applicability but requires more research. Relevance to industry: Few researchers have demonstrated the problem of the frequency-weighting method of the ISO 2631-1 standard. This may have implications to current used ISO frequency-weighting method for evaluating the comfort on the vehicle seats. Therefore, comfortable evaluation of the vehicle seats vibration by the amount of frequency-weighted rms acceleration values obtained by the ISO 2631-1 standard takes cautions.
KW - frequency
KW - occupational health
KW - ride comfort
KW - subjective evaluation
KW - vehicles
KW - whole body vibration
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Occupational Health and Safety (VV900)
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UR - email: maedas@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extension-ladder safety: solutions and knowledge gaps.
AU - Hsiao, H.
AU - Simeonov, P.
AU - Pizatella, T.
AU - Stout, N.
AU - McDougall, V.
AU - Weeks, J.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008///
VL - 38
IS - 11/12
SP - 959
EP - 965
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Hsiao, H.: Protective Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083301506. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - Falls from ladders are the second leading cause for work-related fatalities in the US construction industry. A significant portion of these incidents occurs at building-construction-and-maintenance worksites during the use of extension ladders. This paper presents the results of a critical literature review related to: (1) risk factors associated with falls from extension ladders, (2) practical engineering solutions that may reduce fall-from-extension-ladder incidents, and (3) questions pertaining to ladder safety that remain unanswered. The review results show that the underlying causes of falls involving extension ladders include the ladder-base slipping out, ladders tipping, workers slipping while on ladders or transitioning from a ladder to a surface at height, and mechanical failures. Some engineering control measures are available in the literature; yet, significant knowledge gaps remain. The knowledge-gap analysis identified four actions needed to advance ladder-safety practice: (1) research on visual indicators to assist in setting up ladders at the correct angle, (2) developing and evaluating measures to ease the transition from a ladder to a surface at heights, (3) integrating ladder accessories into a convertible design to ease the carrying, assembling, and storing of multiple accessories, and thus to encourage safe practices, and (4) developing a graphic-oriented practical guide for safe ladder use, maintenance, and mechanical-flaw detection. Relevance to industry: This paper identified knowledge gaps associated with extension-ladder use for advancing ladder-safety interventions. The development and evaluation of ladder-safety innovations will provide the necessary feedback to ladder manufacturers and ladder-standard-setting bodies for design enhancement and will provide workers practical solutions to reduce injury risks associated with extension-ladder use.
KW - accidents
KW - construction workers
KW - falls
KW - knowledge
KW - ladders
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - building workers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
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UR - email: hxh4@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Temporary threshold shifts (TTS) of fingertip vibrotactile perception thresholds from hand-held tool vibration exposures at working surface.
AU - Maeda, S.
AU - Shibata, N.
A2 - Rakheja, S.
A2 - Dong, R. G.
T3 - Special Issue: Workplace vibration exposure characterization, assessment and ergonomic interventions, Special Issue: Workplace vibration exposure.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008///
VL - 38
IS - 9/10
SP - 693
EP - 696
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Maeda, S.: Measurement and Control of Work Environment Research Group, Japan National Institute of Occupational Safety and Health (JNIOSH), Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20083259036. Publication Type: Journal Article. Note: Special Issue: Workplace vibration exposure characterization, assessment and ergonomic interventions, Special Issue: Workplace vibration exposure. Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Objective - The effect of hand-held vibration exposure in the working surface on the temporary threshold shift (TTS) in vibrotactile perception threshold at the fingers has been studied. Method - Subjects were exposed to the hand-held tool with the exposure time of 5 min at different positions in the working surface. A controlled condition with no vibration was included. In order to obtain the TTS in the fingertip vibrotactile perception threshold, the vibrotactile perception thresholds were measured before and after the subjects were exposed to hand-transmitted vibration from the hand-held tool. Results - The results of TTS were different at different positions in the working surface, even though the hand-held tool vibration magnitudes were the same frequency-weighted rms acceleration according to the ISO 5349-1 standard. Conclusions - Even though the tool vibration magnitudes were the same, the TTS values were different in the working surface. The results suggest that the ISO 5349-1 standard needs to be revised to include other factors that many influence the risk of obtaining a vibration-induced injury, such as posture. Relevance to industry - Results from this study demonstrated the problem of the frequency-weighting method of the ISO 5349-1 standard in the working surface. Therefore, in the assembly lines or worktables of the industries, even though the tool position is in the working surface, the employees or employers must consider about the position of the tools to reduce the effect of vibration exposure for preventing the vibration injuries.
KW - exposure
KW - fingers
KW - hands
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - tools
KW - vibration
KW - workers
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - occupational safety
KW - Engineering and Equipment (General) (NN000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083259036&site=ehost-live&scope=site
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UR - email: maedas@h.jnisoh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of tool handle diameter on temporary threshold shift (TTS) of vibrotactile perception.
AU - Shibata, N.
AU - Maeda, S.
A2 - Rakheja, S.
A2 - Dong, R. G.
T3 - Special Issue: Workplace vibration exposure characterization, assessment and ergonomic interventions, Special Issue: Workplace vibration exposure.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008///
VL - 38
IS - 9/10
SP - 697
EP - 702
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Shibata, N.: Measurement and Control of Work Environment Research Group, National Institute of Occupational Safety and Health, Japan, 6-21-1, Nagao, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20083259037. Publication Type: Journal Article. Note: Special Issue: Workplace vibration exposure characterization, assessment and ergonomic interventions, Special Issue: Workplace vibration exposure. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Objective - Temporary threshold shifts (TTSs) of fingertip vibrotactile perception were measured in a laboratory study to examine the effects of handle size in combination with vibration frequency, amplitude, and frequency weighting, on human responses to hand-arm vibration (HAV). Methods - Ten healthy male subjects were exposed to two levels of HAV: 125 Hz-5.0 m/s2 and 125 Hz-20.0 m/s2 (represented as a combination of vibration frequency and rms acceleration) using two different handles (22 and 35 mm in diameter) excited with a shaker. A simplified version of method of limits were used to measure vibrotactile perception thresholds and TTSs were then calculated as the difference between fingertip vibrotactile perception thresholds measured before and after 5 min vibration exposure. Results - At 125 Hz-5.0 m/s2 vibration, the handle size significantly affected TTSs in fingertip vibrotactile perception. In contrast, the handle size did not significantly affect the TTSs at 125 Hz-2.0 m/s2 vibration. Conclusions - Our results suggest that handle size is more sensitive to the TTS in fingertip vibrotactile perception under relatively lower vibration level. From a viewpoint of risk assessment to HAV exposure, TTS after short-term exposure to HAV is indicative of HAV syndrome resulted from long-term exposure to HAV. Since the long-term effect has been the accumulation of repeated short-term effect of HAV, our results suggest that the tool handle size is recommended to be designed based on the vibration level so as to diminish TTS. Relevance to industry - Results obtained from this study show that the range of handle diameter examined in this study does not have a significant influence on TTS in vibrotactile perception. This finding gives fundamental data to the designing of hand-held power tools.
KW - diameter
KW - exposure
KW - fingers
KW - hand tools
KW - men
KW - occupational hazards
KW - occupational health
KW - risk assessment
KW - safety at work
KW - tools
KW - vibration
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - occupational safety
KW - Engineering and Equipment (General) (NN000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083259037&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V31-4R2XCDV-2&_user=6686535&_coverDate=10%2F31%2F2008&_rdoc=8&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235717%232008%23999619990%23697369%23FLA%23display%23Volume)&_cdi=5717&_sort=d&_docanchor=&_ct=23&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=f610897c62f9df4abaec7485704314a0
UR - email: maedas@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic drift of norovirus genotype GII-4 in seven consecutive epidemic seasons in Hungary.
AU - Reuter, G.
AU - Pankovics, P.
AU - Szucs, G.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2008///
VL - 42
IS - 2
SP - 135
EP - 140
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20083173134. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - Background: Noroviruses are common pathogens in human gastroenteritis outbreaks worldwide. They belong to a genetically diverse group of RNA viruses with multiple genogroups (G) and genotypes. Genotype GII-4 norovirus (Lordsdale) is the predominant agent in epidemics. Objectives: To investigate the genetic variation in GII-4 strains isolated during seven epidemic seasons in Hungary from November 2000 to June 2007. Study design: Using the prospective epidemiological surveillance of norovirus outbreaks in Hungary, GII-4 strains were selected for further genetic analysis. After phylogenetic analysis, RNA-polymerase (open reading frame 1; ORF1), capsid (ORF2) and the ORF1/ORF2 junction were analysed by RT-PCR and sequencing. Results: Three hundred and seventy-seven (76.8%) of 491 confirmed norovirus outbreaks were caused by genotype GII-4. GII-4 was the predominant genotype in six of the seven epidemic seasons. Four main GII-4 variants - epidemic point mutants - (GII-4-2000, GII-4-2002, GII-4-2004 and GII-4-2006b) were detected, with each variant predominating in two consecutive epidemic seasons. Conclusions: Genotype GII-4 was confirmed as the predominant genetic type in epidemic norovirus seasons in Hungary. Genetic drift successfully promotes the re-emergence of GII-4 variants in the population. The elevated number of norovirus outbreaks in the population predicts the emergence of new GII-4 genetic variants as part of an international epidemic.
KW - disease prevalence
KW - epidemics
KW - epidemiology
KW - gastroenteritis
KW - gastrointestinal diseases
KW - genetic analysis
KW - genetic drift
KW - genotypes
KW - human diseases
KW - molecular genetics
KW - molecular genetics techniques
KW - outbreaks
KW - viral diseases
KW - Hungary
KW - man
KW - Norovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Caliciviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - viral infections
KW - winter vomiting disease
KW - winter vomiting virus
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083173134&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/13866532
UR - email: reuter.gabor@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dietary habits in a child population in relation to caries experience.
AU - Llena, C.
AU - Forner, L.
JO - Caries Research
JF - Caries Research
Y1 - 2008///
VL - 42
IS - 5
SP - 387
EP - 393
CY - Basel; Switzerland
PB - S Karger AG
SN - 0008-6568
AD - Llena, C.: Primary Care in Dental Public Health Service, Department 9, University of Valencia, Valencia, Spain.
N1 - Accession Number: 20083293040. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 9005-25-8. Subject Subsets: Dairy Science; Human Nutrition; Public Health
N2 - Sugar consumption in Spain has remained constant at around 80 g/day since the 1970s. Although intake as sugar has fallen considerably, to around 13.5 g/person/day, the intake in processed foods has risen. Meanwhile, caries prevalence is falling or stabilizing. This situation is common in developed countries, where the impact of diet on caries has altered, probably through greater use of fluoridated products. In the Valencia region, children habitually eat sugary foods and drinks and snacks that contain starches or sugars and starches. The present study analyzed the association between caries experience, quantified as the sum of the dfs and DMFS indices, and the consumption of cariogenic foods in a population of children between the ages of 6 and 10 with low caries prevalence. A self-administered food consumption frequency questionnaire filled in by the parents was used to evaluate how often the foods on the list were consumed by the children, which was then related to their caries experience. Sweet snacks, industrial bread and soft drink consumption showed a positive association with caries while cheese and nuts showed a negative association. Logistic regression suggested that consuming sugary liquids and foods rich in semi-hydrolyzed starch increased the chances of suffering caries by 1.05 and 1.13 respectively.
KW - beverages
KW - bread
KW - cheeses
KW - children
KW - dental caries
KW - diet
KW - disease prevalence
KW - feeding habits
KW - nuts
KW - soft drinks
KW - starch
KW - sugar
KW - surveys
KW - sweets
KW - Spain
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - caries
KW - drinks
KW - eating habits
KW - teeth caries
KW - tooth decay
KW - Diet Studies (VV110)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083293040&site=ehost-live&scope=site
UR - http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=154784&Ausgabe=240002&ProduktNr=224219
UR - email: llena@uv.es
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A Legionnaires' disease outbreak: a water blaster and roof-collected rainwater systems.
AU - Simmons, G.
AU - Jury, S.
AU - Thornley, C.
AU - Harte, D.
AU - Mohiuddin, J.
AU - Taylor, M.
JO - Water Research (Oxford)
JF - Water Research (Oxford)
Y1 - 2008///
VL - 42
IS - 6/7
SP - 1449
EP - 1458
CY - Oxford; UK
PB - Elsevier
SN - 0043-1354
AD - Simmons, G.: Auckland Regional Public Health Service, Private Bag 92 605, Symonds Street, Auckland 1035, New Zealand.
N1 - Accession Number: 20083153568. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health; Soils & Fertilizers; Irrigation & Drainage
N2 - In February 2006, an outbreak of Legionnaires' disease (LD) was identified in Beachlands, a small, isolated east Auckland suburb. It was investigated through case finding, a case-control study, sampling potential sources of infection and by molecular typing (using sequence-based typing (SBT) of all Legionella pneumophila serogroup 1 (Lp1) isolates). Lp1 was isolated from the respiratory tract of one case, the roof-collected rainwater systems of five households (three associated with cases) and from a water blaster at a nearby marina. All isolates were indistinguishable, exhibiting the same SBT allele pattern. Three LD cases lived within 500 m of the water blaster (the fourth case within 1250 m) and downwind in prevailing conditions. Another domestic roof-collected rainwater supply contaminated by Lp1 (identical SBT pattern) was incidentally identified in another suburb 4 km east of Beachlands. This is the first outbreak of LD linked to roof-collected rainwater supplies and the first isolation of Legionella from these systems in New Zealand. Aerosols containing Legionella discharged to air by the marina water blaster may have infected some cases directly or may have seeded roof-collected rainwater systems. Some cases may have been exposed by contaminated bathroom showers. Roof-collected rainwater systems need appropriate design, careful cleaning and the maintenance of hot water temperatures at a minimum of 60°C to reduce the chances of Legionella multiplying. Further research into the ecology of Legionella in roof-collected rain water systems is indicated.
KW - aerosols
KW - contamination
KW - human diseases
KW - Legionnaires' disease
KW - outbreaks
KW - pollution
KW - rain
KW - water systems
KW - New Zealand
KW - Legionella pneumophila
KW - man
KW - Legionella
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - bacterium
KW - environmental pollution
KW - rainfall
KW - Water Resources (PP200)
KW - Meteorology and Climate (PP500)
KW - Pollution and Degradation (PP600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083153568&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V73-4PXDKYC-2&_pvudi=B6V73-4PYP6XR-1&_rdoc=12&_srch=doc-info(%23toc%235831%232008%23999579993%23683127%23FLA%23display%23Volume)&_user=6686535&_fmt=high&_orig=browse&_ct=51&_sort=d&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=f1183023e46109103548560949d87e14
UR - email: gregs@adhb.govt.nz\SJury@adhb.govt.nz\CraigT@adhb.govt.nz\David.harte@esr.cri.nz\JasmineM@adhb.govt.nz\michael_taylor@moh.govt.nz
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Multigenerational exposure to ethinyl estradiol affects bone geometry, but not bone mineral density in rats.
AU - Hotchkiss, C. E.
AU - Weis, C.
AU - Blaydes, B.
AU - Newbold, R.
AU - Delclos, K. B.
T2 - Bone
JO - Bone
JF - Bone
Y1 - 2008///
VL - 43
IS - 1
SP - 110
EP - 118
CY - San Diego; USA
PB - Elsevier Inc.
SN - 8756-3282
AD - Hotchkiss, C. E.: The National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20083177276. Publication Type: Journal Article. Language: English. Number of References: 89 ref. Registry Number: 50-28-2, 101-42-8. Subject Subsets: Human Nutrition
N2 - Estrogenic compounds are known to prevent bone loss in ovariectomized adult rats; however, their effects on bone in developing and reproductively-intact rats are less well-understood. In a large multigenerational experiment 0, 2, 10, or 50 ppb ethinyl estradiol (EE) in the diet was fed to intact male and female rats from conception until either weaning, postnatal day 140, or continuously for 2 years. Vertebrae (lumbar and caudal) and femurs were collected from subsets of these animals at necropsy at 48 days, 70 days, 140 days, or 2 years of age and subjected to dual-energy X-ray absorptiometry (DXA) scanning to measure bone mineral density (BMD), bone mineral content (BMC), and bone area. In addition, the length, cross-sectional area, marrow area, and cortical bone area of the femurs were measured directly in all animals at PND 140 and 2 years. Continous dietary intake of 50 ppb EE decreased body weight by 8-27%. BMD adjusted for body weight was not affected by EE, with the exception of an increase in the caudal vertebrae in males treated with 50 ppb EE. In female rats, continuous treatment with 50 ppb EE decreased length and cross-sectional area of the femur. The length of the femur was decreased in the first two generations following institution of a phytoestrogen-free diet at the initiation of the study in all animals, including controls, but returned to the original length by the third or fourth generation. The cross-sectional area of the femur also varied by generation. In conclusion, a high dose of EE throughout the lifespan resulted in decreased bone size in females, which could reduce the force required to break the bone. Furthermore, dietary changes may have epigenetic effects which persist for multiple generations.
KW - animal models
KW - body weight
KW - bone density
KW - bone formation
KW - bones
KW - estradiol
KW - femur
KW - fenuron
KW - laboratory animals
KW - spine
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bone calcification
KW - endocrine disruptors
KW - ethinyl estradiol
KW - oestradiol
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083177276&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/87563282
UR - email: chotchki@wanprc.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of (-)-Epigallocatechin gallate on the redox reactions of human hemoglobin.
AU - Jia, Y. P.
AU - Alayash, A. I.
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2008///
VL - 45
IS - 5
SP - 659
EP - 666
CY - New York; USA
PB - Elsevier
SN - 0891-5849
AD - Jia, Y. P.: Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), National Institutes of Health (NIH) Campus, 8800 Rockville Pike, Bldg. 29, Rm. 129, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093017326. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Human Nutrition
N2 - The toxicity of acellular hemoglobin (Hb)-based therapeutics has been attributed in part to the uncontrolled oxidative reactions. A variety of antioxidant strategies to ameliorate potential oxidative damage in vivo have been suggested. We have examined the effects of (-)-epigallocatechin gallate (EGCG), a green tea polyphenol compound widely regarded as a chain-breaking antioxidant, on the oxidative stability of diaspirin crosslinked Hb (DBBF) and its cytotoxic ferryl intermediate. DBBF (ferrous) was rapidly oxidized to the ferric form in the presence of EGCG relative to the normal spontaneous oxidation of this Hb. The fast elimination of ferrous Hb is probably due to the ability of EGCG to produce hydrogen peroxide (H2O2) as these reactions were almost completely reversed by the addition of catalase and superoxide dismutase to the reaction medium. EGCG, however, effectively reduced ferryl back to ferric Hb in a biphasic kinetic reaction at physiological pH. At acidic pH where the autoreduction of protonated ferryl Hb is enhanced, a monophasic reduction process of the ferryl heme is achieved. A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs.
KW - antioxidants
KW - flavanols
KW - haemoglobin
KW - lipid peroxidation
KW - oxidation
KW - polyphenols
KW - redox reactions
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - epigallocatechin gallate
KW - hemoglobin
KW - oxidation reduction reactions
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093017326&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4SKB3C2-3&_user=6686535&_coverDate=09%2F01%2F2008&_rdoc=16&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234940%232008%23999549994%23695514%23FLA%23display%23Volume)&_cdi=4940&_sort=d&_docanchor=&_ct=24&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=df1c7929aecc845d2f3a54dc22a3248e
UR - email: yiping.jia@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of caffeine and sympathomimetic alkaloids in weight loss supplements by high-performance liquid chromatography.
AU - Evans, R. L.
AU - Siitonen, P. H.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 2008///
VL - 46
IS - 1
SP - 61
EP - 67
CY - Niles; USA
PB - Preston Publications
SN - 0021-9665
AD - Evans, R. L.: National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Division of Biochemical Toxicology, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083071895. Publication Type: Journal Article. Language: English. Registry Number: 58-08-2. Subject Subsets: Human Nutrition; Plant Breeding; Horticultural Science; Public Health; Weeds; Plant Genetic Resources
N2 - Reversed-phase high-performance liquid chromatography utilizing photodiode array detection is used for the simultaneous determination of caffeine and nine alkaloids from Citrus aurantium (CA) and ephedra (EA) contained in dietary weight loss products. Since the Food and Drug Administration (FDA) ban of EA, manufacturers have substituted CA in their weight loss formulations, usually combined with high levels of caffeine. The alkaloids contained in CA have some physiological effects similar to those of the EA alkaloids and are, therefore, cause for concern. Caffeine has been shown to potentiate the toxicity of the EA alkaloids. Recently, a federal judge overturned the absolute ban and allowed marketing of low levels (<10 mg/day) of total EA alkaloids. To support an absolute ban, the FDA is now compelled to perform dose-dependent toxicology studies to determine the toxic dose(s) of EA. The toxicity of the CA compounds is largely unknown, especially in combination with caffeine. The described method enables quantitation over a wide range of product formulations. Recoveries range from 91% to 100% from a variety of fortified plant matrices.
KW - alkaloids
KW - body weight
KW - caffeine
KW - chemical composition
KW - food supplements
KW - HPLC
KW - plant composition
KW - regulations
KW - sour oranges
KW - sympathomimetics
KW - toxicity
KW - weight loss diets
KW - wild relatives
KW - Citrus
KW - Citrus aurantium
KW - Ephedra
KW - man
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Citrus
KW - Ephedraceae
KW - Gnetopsida
KW - gymnosperms
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - chemical constituents of plants
KW - high performance liquid chromatography
KW - rules
KW - Rutales
KW - Seville oranges
KW - Laws and Regulations (DD500)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Plant Composition (FF040)
KW - Weeds and Noxious Plants (FF500)
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083071895&site=ehost-live&scope=site
UR - http://www.j-chrom-sci.com/abstracts/2008/january/061-evans.html
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.
AU - Lee, I. P.
AU - Kang, B. H.
AU - Roh, J. K.
AU - Kim, J. R.
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 1
SP - 87
EP - 95
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Lee, I. P.: Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20083022811. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Human Nutrition
N2 - The Brazilian mushroom Agaricus blazei Murill has antimutagenic, antioxidant, immunostimulatory and antitumorigenic activities, and is increasingly consumed as a health food worldwide. We undertook the present study to evaluate the chronic toxicity and oncogenicity of A. blazei Murill in F344 rats. To establish a no-observed-adverse-effect level (NOAEL), four treatment groups of 100 rats each (50 males and 50 females) were fed a powder diet containing lyophilized A. blazei aqueous extract at 0, 6250, 12 500, and 25 000 ppm for up to 2 years. During this period, there was no remarkable change in mean body weight, body weight gain, hematologic or serum chemistry parameters, or absolute or relative organ weights in control or treatment groups. Mortality in male treatment groups (26%, 16%, and 30%), however, was significantly lower than in controls (48%). Histopathological studies showed no increased incidence of tumors in any treatment group, and total tumor incidence across all groups was comparable to historical data. In conclusion, an A. blazei Murill lyophilized powder diet even at 25 000 ppm (1176 mg/kg b.w./day for male rats and 1518 mg/kg b.w./day for female rats) resulted in no remarkable carcinogenic effects in F344 rats over a 2-year period. Therefore, the dietary NOAEL is 25 000 ppm.
KW - animal models
KW - carcinogenesis
KW - diets
KW - laboratory animals
KW - neoplasms
KW - oncogenicity
KW - Agaricaceae
KW - Agaricus
KW - rats
KW - Agaricaceae
KW - Agaricales
KW - Agaricomycetes
KW - Agaricomycotina
KW - Basidiomycota
KW - fungi
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Agaricus
KW - Agaricus blazei
KW - cancers
KW - fungus
KW - Crop Produce (QQ050)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083022811&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: iplee0823@aol.com
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
AU - Whittaker, P.
AU - Clarke, J. J.
AU - San, R. H. C.
AU - Betz, J. M.
AU - Seifried, H. E.
AU - Jager, L. S. de
AU - Dunkel, V. C.
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 1
SP - 168
EP - 174
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083022814. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Public Health; Aromatic & Medicinal Plants
N2 - Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both D-kawain and DL-kawain, were evaluated in L5I78Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5I78Y mouse lymphoma mutation assay with the addition of human liver S9 activation.
KW - animal models
KW - beverages
KW - extracts
KW - in vitro
KW - lymphoma
KW - mutagenicity
KW - mutational analysis
KW - neoplasms
KW - toxicity
KW - man
KW - mice
KW - Piper methysticum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - Piper
KW - Piperaceae
KW - Piperales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - cancers
KW - drinks
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083022814&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The public health approach to occupational injury research: from surveillance to prevention.
AU - Stout, N. A.
JO - Safety Science
JF - Safety Science
Y1 - 2008///
VL - 46
IS - 2
SP - 230
EP - 233
CY - Oxford; UK
PB - Elsevier
SN - 0925-7535
AD - Stout, N. A.: Division of Safety Research, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083098146. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Public Health
N2 - The National Institute for Occupational Safety and Health (NIOSH) in the US uses the public health model as the framework for occupational injury prevention research. This model is described, along with where we have made progress in this research process, and where we need to focus our efforts in the future. The specific role of surveillance in research and prevention of occupational injuries is also discussed, as well as the importance of partnership efforts to facilitate the transfer of research to practice. Suggestions are provided for stimulating a global approach to surveillance and to the transfer of research to practice.
KW - accident prevention
KW - human diseases
KW - models
KW - occupational hazards
KW - public health
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098146&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VF9-4PHSFC1-1&_user=6686535&_coverDate=02%2F29%2F2008&_rdoc=9&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236005%232008%23999539997%23679623%23FLA%23display%23Volume)&_cdi=6005&_sort=d&_docanchor=&_ct=18&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=493a9b7723d29d4ed3708bda5de2fe0f
UR - email: nas5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.
AU - Mei, N.
AU - Hu, J. X.
AU - Churchwell, M. I.
AU - Guo, L.
AU - Moore, M. M.
AU - Doerge, D. R.
AU - Chen, T.
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 2
SP - 628
EP - 636
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Mei, N.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083040911. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Human Nutrition
N2 - In addition to occupational exposures to acrylamide (AA), concerns about AA health risks for the general population have been recently raised due to the finding of AA in food. In this study, we evaluated the genotoxicity of AA and its metabolite glycidamide (GA) in L5178Y/Tk+/- mouse lymphoma cells. The cells were treated with 2-18 mM of AA or 0.125-4 mM of GA for 4 h without metabolic activation. The DNA adducts, mutant frequencies and the types of mutations for the treated cells were examined. Within the dose range tested, GA induced DNA adducts of adenine and guanine [N3-(2-carbamoyl-2-hydroxyethyl)-adenine and N7-(2-carbamoyl-2-hydroxyethyl)-guanine] in a linear dose-dependent manner. The levels of guanine adducts were consistently about 60-fold higher across the dose range than those of adenine. In contrast, no GA-derived DNA adducts were found in the cells treated with any concentrations of AA, consistent with a lack of metabolic conversion of AA to GA. However, the mutant frequency was significantly increased by AA at concentrations of 12 mM and higher. GA was mutagenic starting with the 2 mM dose, suggesting that GA is much more mutagenic than AA. The mutant frequencies were increased with increasing concentrations of AA and GA, mainly due to an increase of proportion of small colony mutants. To elucidate the underlying mutagenic mechanism, we examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for mutants induced by AA or GA. Compared to GA induced mutations, AA induced more mutants whose LOH extended to D11Mit22 and D11Mit74, an alteration of DNA larger than half of the chromosome. Statistical analysis of the mutational spectra revealed a significant difference between the types of mutations induced by AA and GA treatments (P=0.018). These results suggest that although both AA and GA generate mutations through a clastogenic mode of action in mouse lymphoma cells, GA induces mutations via a DNA adduct mechanism whereas AA induces mutations by a mechanism not involving the formation of GA adducts.
KW - acrylamides
KW - animal models
KW - cell lines
KW - genotoxicity
KW - laboratory animals
KW - lymphoma
KW - metabolites
KW - mutagenicity
KW - mutational analysis
KW - mutations
KW - neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083040911&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: nan.mei@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Active and passive smoking and depression among Japanese workers.
AU - Nakata, A.
AU - Takahashi, M.
AU - Ikeda, T.
AU - Hojou, M.
AU - Nigam, J. A.
AU - Swanson, N. G.
JO - Preventive Medicine
JF - Preventive Medicine
Y1 - 2008///
VL - 46
IS - 5
SP - 451
EP - 456
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0091-7435
AD - Nakata, A.: Division of Applied Research and Technology, MSC24, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083147168. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - Objective. To assess the relation of passive and active smoking to depressive symptoms in 1839 men and 931 women working in a suburb of Tokyo in 2002. Method. Self-reported smoking history and exposure to passive smoking (no, occasional, or regular) at work and at home. Depressive symptoms according to the Center for Epidemiologic Studies Depression Scale, with a cut-off point of 16. Results. Compared to never smokers unexposed to passive smoking, never smokers reporting regular and occasional exposure to passive smoking at work had increased depressive symptoms. The adjusted odds ratios (aORs) were 1.92 (95% confidence interval (CI) 1.14, 3.23) for regular exposure and 1.63 (95% CI 1.08, 2.47) for occasional exposure. Current smokers had significantly increased depressive symptoms (aOR ranging from 2.25 to 2.38) but former smokers had only marginal increases of depressive symptoms (aOR ranging from 1.43 to 1.55). Gender did not modify the effects of active/passive smoking on depressive symptoms. Conclusion. Passive smoking at work and current smoking appear associated with higher levels of depressive symptoms.
KW - depression
KW - exposure
KW - human diseases
KW - occupational health
KW - passive smoking
KW - risk
KW - symptoms
KW - tobacco smoking
KW - workers
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083147168&site=ehost-live&scope=site
UR - http://www.sciencedirect.co./science/journal/00917435
UR - email: cji5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice.
AU - Cho WanSeob
AU - Han BeomSeok
AU - Lee HaKyung
AU - Kim CheulKyu
AU - Nam KiTaek
AU - Park KiDae
AU - Choi Mina
AU - Kim SungJun
AU - Kim SeungHee
AU - Jeong JaYoung
AU - Jang DongDeuk
T2 - Food and Chemical Toxicology
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 5
SP - 1666
EP - 1673
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Cho WanSeob: Division of Toxicologic Pathology, Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Korea FDA, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20083085803. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - 3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400 ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400 ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400 ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400 ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400 ppm groups. A delayed total estrus cycle length was observed in the 400 ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100 ppm (18.05 mg/kg/day for males and 15.02 mg/kg/day for females).
KW - animal models
KW - food contamination
KW - food processing
KW - human diseases
KW - laboratory animals
KW - neoplasms
KW - oestrus
KW - ovaries
KW - toxicity
KW - man
KW - mice
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - cancers
KW - estrus
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083085803&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: ddjang@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A review of work schedule issues and musculoskeletal disorders with an emphasis on the healthcare sector.
AU - Caruso, C. C.
AU - Waters, T. R.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008///
VL - 46
IS - 6
SP - 523
EP - 534
CY - Kawasaki; Japan
PB - National Institute of Occupational Safety and Health
SN - 0019-8366
AD - Caruso, C. C.: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20093017819. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - Musculoskeletal disorders (MSDs) are a significant cause of morbidity in Healthcare workers. The influence of shift work and long work hours on risk for MSDs is an area that needs further exploration. The purpose of this report is to assess research progress and gaps across studies that examined the relationship between demanding work schedules and MSD outcomes. A literature search identified 23 peer-reviewed publications in the English language that examined MSDs and long work hours, shift work, extended work shifts, mandatory overtime, or weekend work. Eight studies that examined long work hours and had some controls for physical job demands reported a significant increase in one or more measures of MSDs. Fourteen studies examining shift work had incomparable methods and types of shift work, and therefore, no clear trends in findings were identified. A small number of studies examined mandatory overtime, work on weekends and days off, and less than 10 h off between shifts. Given the complexity of the work schedule research topic, relatively few studies have adequately examined the relationship of work schedules and musculoskeletal outcomes. The review discusses research gaps including methodological issues and suggests research priorities.
KW - health care workers
KW - human diseases
KW - musculoskeletal system
KW - occupational hazards
KW - occupational health
KW - research
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - skeletomuscular system
KW - studies
KW - Health Services (UU350)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093017819&site=ehost-live&scope=site
UR - http://www.jniosh.go.jp/en/indu_hel/index.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preventing household transmission of Shiga toxin-producing Escherichia coli O157 infection: promptly separating siblings might be the key.
AU - Werber, D.
AU - Mason, B. W.
AU - Evans, M. R.
AU - Salmon, R. L.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 46
IS - 8
SP - 1189
EP - 1196
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Werber, D.: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, UK.
N1 - Accession Number: 20083152318. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background. Preventing household transmission of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection is important because of the ease of interpersonal transmission and the potential disease severity. Methods. We conducted a retrospective cohort study of households associated with an outbreak of STEC O157 infection in South Wales, United Kingdom, in autumn 2005. We investigated whether characteristics of the primary case patient or the household were predictors for secondary household transmission of STEC O157 infection. Furthermore, we estimated the proportion of cases that might be prevented by isolation (e.g., hospitalization) of the primary case patient immediately after the microbiological diagnosis and the number of patients with STEC O157 who would need to be isolated to prevent 1 case of hemolytic uremic syndrome. Based on dates of symptom onset, case patients in households were classified as having primary, coprimary, or secondary infection. Secondary cases were considered to be preventable if the secondary case patient's symptoms started >1 incubation period (4 days) after the date of microbiological diagnosis of the primary case. Results. Eighty-nine (91%) of 98 eligible households were enrolled. Among 20 households (22%), 25 secondary cases were ascertained. Thirteen secondary cases (56%) occurred in siblings of the primary case patients; hemolytic uremic syndrome developed in 4 of these siblings. Presence of a sibling (risk ratio, 3.8; 95% confidence interval, 0.99-14.6) and young age (<5 years) of the primary case patient (risk ratio, 2.03; 95% confidence interval, 0.99-41.6) were independent predictors for households in which secondary cases occurred. Of the 15 secondary cases for which complete information was available, 7 (46%) might have been prevented. When restricting isolation to primary case patients who were aged <10 years and who had a sibling, we estimated the number of patients who would need to be isolated to prevent 1 case of hemolytic uremic syndrome to be 47 patients (95% confidence interval, 16-78 patients). Conclusions. Promptly separating pediatric patients with STEC O157 infection from their young siblings should be considered.
KW - bacterial diseases
KW - bacterial toxins
KW - children
KW - disease transmission
KW - epidemiology
KW - families
KW - haemolytic uraemic syndrome
KW - households
KW - human diseases
KW - intrafamilial transmission
KW - outbreaks
KW - UK
KW - Wales
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Britain
KW - E. coli
KW - hemolytic uremic syndrome
KW - Shiga toxin
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152318&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/587670
UR - email: werberd@rki.de
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States.
AU - Wu, K. M.
AU - Ghantous, H.
AU - Birnkrant, D. B.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 8
SP - 2606
EP - 2610
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Wu, K. M.: Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20083227803. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen®) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen®) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated.
KW - herbal drugs
KW - mutagenicity
KW - pharmacology
KW - plant extracts
KW - regulations
KW - reviews
KW - tea
KW - toxicity
KW - USA
KW - Camellia sinensis
KW - Camellia
KW - Theaceae
KW - Theales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - herbal medicines
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083227803&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: kueimeng.wu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in l5178Y mouse lymphoma cells.
AU - Whittaker, P.
AU - Clarke, J. J.
AU - San, R. H. C.
AU - Begley, T. H.
AU - Dunkel, V. C.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2008///
VL - 46
IS - 8
SP - 2928
EP - 2933
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083227848. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 431-03-8. Subject Subsets: Dairy Science
N2 - Diacetyl (2,3-butanedione) is a yellowish liquid that is usually mixed with other ingredients to produce butter flavor or other flavors in a variety of food products. Inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Recent findings have shown irreversible obstructive lung disease among workers not only in the microwave popcorn industry, but also in flavoring manufacture, and in chemical synthesis of diacetyl, a predominant chemical for butter flavoring. It has been reported that perfluorochemicals utilized in food packaging are migrating into foods and may be sources of oral exposure. Relatively small quantities of perfluorochemicals are used in the manufacturing of paper or paperboard that is in direct contact with food to repel oil or grease and water. Because of recent concerns about perfluorochemicals such as those found on microwave popcorn bags (e.g. Lodyne P208E®) and diacetyl in foods, we evaluated both compounds for mutagenicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Lodyne P208E® was less toxic than diacetyl and did not induce a mutagenic response. Diacetyl induced a highly mutagenic response in the L5178Y mouse lymphoma mutation assay in the presence of human liver S9 for activation. The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus.
KW - animal models
KW - butter
KW - diacetyl
KW - flavouring
KW - food contamination
KW - food packaging
KW - genes
KW - laboratory animals
KW - lymphoma
KW - mutations
KW - toxicity
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - flavoring
KW - food contaminants
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Storage and Preservation (QQ110)
KW - Food Additives (QQ130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083227848&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monitoring and removal of CO in blasting operations.
AU - Harris, M. L.
AU - Mainiero, R. J.
JO - Safety Science
JF - Safety Science
Y1 - 2008///
VL - 46
IS - 10
SP - 1393
EP - 1405
CY - Oxford; UK
PB - Elsevier
SN - 0925-7535
AD - Harris, M. L.: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, USA.
N1 - Accession Number: 20083316554. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 630-08-0. Subject Subsets: Public Health
N2 - Toxic fumes produced by detonating explosives in surface mining and construction operations pose potential hazards to workers and the public. Blasting operations produce both toxic and nontoxic gaseous products; the toxic products are mainly carbon monoxide (CO) and the oxides of nitrogen (NOx). Since 1988, there have been 17 documented incidents in the United States and Canada in which carbon monoxide (CO) is suspected to have migrated through ground strata into occupied enclosed spaces as a result of proximate trench blasting or surface mine blasting. These incidents resulted in 39 suspected or medically verified carbon monoxide poisonings as well as one fatality. At worst people may be fatally poisoned and the least to be expected is increased public objections to blasting. Local and state agencies could demand a cessation of the blasting requiring more expensive mechanical means to break the rock. This paper discusses the most feasible means of preventing CO migration, mitigating CO that has migrated, and detecting CO in an underground enclosed space and may help reduce the exposure of unsuspecting area residents to carbon monoxide and help prevent the implementation of unnecessary regulations and limitations on blasting. Single-hole shots and small-scale multiple-hole blasts were performed that indicate promising means of prevention and mitigation.
KW - carbon monoxide
KW - explosions
KW - explosive hazard
KW - health hazards
KW - monitoring
KW - removal
KW - Pennsylvania
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - surveillance systems
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083316554&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VF9-4R71KFB-1&_user=6686535&_coverDate=12%2F31%2F2008&_rdoc=2&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236005%232008%23999539989%23701244%23FLA%23display%23Volume)&_cdi=6005&_sort=d&_docanchor=&_ct=9&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=ceaff66a3c9d3c4b4edcb4d9d42a04b9
UR - email: mharris@cdc.gov\rmainiero@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antiviral therapy and outcomes in hospitalized patients with influenza.
AU - Chan-Tack, K. M.
AU - Murray, J. S.
T2 - Clinical Infectious Diseases
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 46
IS - 10
SP - 1628
EP - 1629
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Chan-Tack, K. M.: Division of Antiviral Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20083152386. Publication Type: Correspondence. Language: English. Subject Subsets: Public Health
KW - antiviral agents
KW - drug therapy
KW - human diseases
KW - influenza
KW - Influenza viruses
KW - viral diseases
KW - Maryland
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chemotherapy
KW - flu
KW - United States of America
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152386&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/587751
UR - email: kirk.chan-tack@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transmission classification model to determine place and time of infection of tuberculosis cases in an urban area.
AU - Vries, G. de
AU - Baars, H. W. M.
AU - Sebek, M. M. G. G.
AU - Hest, N. A. H. van
AU - Richardus, J. H.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2008///
VL - 46
IS - 12
SP - 3924
EP - 3930
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Vries, G. de: Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20093024586. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - We conducted a population-based study in the Rotterdam region of The Netherlands to determine the place and time of infection of tuberculosis (TB) cases using conventional epidemiological and genotyping information. In particular, we focused on the extent of misclassification if genotyping was not combined with epidemiological information. Cases were divided into those with a unique mycobacterial DNA fingerprint, a clustering fingerprint, and an unknown fingerprint. We developed transmission classification trees for each category to determine whether patients were infected in a foreign country or recently (≤2 years) or remotely (>2 years) infected in The Netherlands. Of all TB cases during the 12-year study period, 38% were infected in a foreign country, 36% resulted from recent transmission in The Netherlands, and 18% resulted from remote infection in The Netherlands, while in the remaining cases (9%) either the time or place of infection could not be determined. The conventional epidemiological data suggested that at least 29% of clustered cases were not part of recent chains of transmission. Cases with unknown fingerprints, almost all culture negative, relatively frequently had confirmed epidemiological links with a recent pulmonary TB case in The Netherlands and were more often identified by contact tracing. Our findings highlight the idea that genotyping should be combined with conventional epidemiological investigation to establish the place and time of infection of TB cases as accurately as possible. A standardized way of classifying TB into recently, remotely, and foreign-acquired disease provides indicators for surveillance and TB control program performance that can be used to decide on interventions and allocation of resources.
KW - disease surveys
KW - disease transmission
KW - DNA fingerprinting
KW - epidemiology
KW - genotypes
KW - human diseases
KW - molecular epidemiology
KW - molecular genetics techniques
KW - mycobacterial diseases
KW - respiratory diseases
KW - tuberculosis
KW - Netherlands
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - disease surveillance
KW - lung diseases
KW - mycobacterial infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093024586&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: devriesg@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Regulation of probiotic substances as ingredients in foods: premarket approval or "generally recognized as safe" notification.
AU - Mattia, A.
AU - Merker, R.
T3 - Developing probiotics as food and drugs: scientific and regulatory challenges.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 46
IS - S2
SP - S115
EP - S118
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Mattia, A.: Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-255, College Park, MD 20740, USA.
N1 - Accession Number: 20083152284. Publication Type: Journal Article. Note: Developing probiotics as food and drugs: scientific and regulatory challenges. Language: English. Subject Subsets: Public Health
N2 - This article discusses options and examples of regulations or "generally recognized as safe" determinations that are related to microorganisms in food. A balanced picture of information about the microorganism and its characteristics is needed to make conclusions about its safety.
KW - food products
KW - ingredients
KW - intestinal microorganisms
KW - probiotics
KW - regulations
KW - safety
KW - gut flora
KW - intestinal micro-organisms
KW - rules
KW - Laws and Regulations (DD500)
KW - Other Produce (QQ070)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Microbiology (General) (ZZ390)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152284&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/523329
UR - email: antonia.mattia@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - US civilian smallpox preparedness and response program, 2003.
AU - Strikas, R. A.
AU - Neff, L. J.
AU - Rotz, L.
AU - Cono, J.
AU - Knutson, D.
AU - Henderson, J.
AU - Orenstein, W. A.
T3 - Special Issue: Posteradication vaccination against smallpox.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 46
IS - S3
SP - S157
EP - S167
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Strikas, R. A.: National Vaccine Program Office, US Department of Health and Human Services, 200 Independence Ave. SW, Washington, DC 20201, USA.
N1 - Accession Number: 20083152295. Publication Type: Journal Article. Note: Special Issue: Posteradication vaccination against smallpox. Language: English. Subject Subsets: Public Health
N2 - Variola virus, the cause of smallpox disease, has been deemed a possible bioterrorism agent. Since November 2001, federal, state, and local public health partners implemented activities to prepare for a possible smallpox outbreak. The Centers for Disease Control and Prevention (CDC) produced and delivered training and educational materials for smallpox preparedness in many formats, developed detailed smallpox vaccine information statements about vaccine contraindications and vaccination site care, and established mechanisms to monitor and respond to adverse events after smallpox vaccination. The last included enhancements to the Vaccine Adverse Event Reporting System, a pregnancy registry for inadvertently vaccinated pregnant women, and a Clinician Telephone Information Line to collect reports about adverse events. The civilian responder vaccination program was conducted with rigorous safety procedures, and few historically recognized adverse events were observed. However, myocarditis and/or pericarditis was newly recognized as an adverse event caused by the New York City Board of Health vaccinia vaccine strain. This smallpox preparedness program put into place a number of measures to advance the United States' readiness for a smallpox outbreak that have assisted in preparedness for other threats.
KW - adverse effects
KW - control programmes
KW - health education
KW - health protection
KW - human diseases
KW - immunization
KW - outbreaks
KW - pregnancy
KW - public health
KW - reviews
KW - safety
KW - smallpox
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Variola virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - control programs
KW - gestation
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152295&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/524751
UR - email: Raymond.Strikas@psc.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The smallpox vaccine injury compensation program.
AU - Clark, P. T.
AU - Levin, S.
T3 - Special Issue: Posteradication vaccination against smallpox.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 46
IS - S3
SP - S179
EP - S181
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Clark, P. T.: US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, and Smallpox Vaccine Injury Compensation Program, Rockville, Maryland, USA.
N1 - Accession Number: 20083152297. Publication Type: Journal Article. Note: Special Issue: Posteradication vaccination against smallpox. Language: English. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - In January 2003, the Secretary of the US Department of Health and Human Services (DHHS) announced that certain individuals should receive smallpox vaccine or other countermeasures to be prepared to serve the civilian population in the event of a smallpox bioterrorism event. In April 2003, Congress passed and the President signed the Smallpox Emergency Personnel Protection Act of 2003. This act created the Smallpox Vaccine Injury Compensation Program to provide medical and lost employment income coverage as a payer of last resort to persons who sustain a covered medical injury as a direct result of receiving smallpox vaccination voluntarily under a DHHS-approved smallpox emergency response plan. As of September 2006, 62 persons had requested benefits, of whom 19 had been determined to be medically eligible, 27 were denied benefits, and 16 submitted the request after the legislatively defined filing deadline.
KW - adverse effects
KW - health policy
KW - health protection
KW - human diseases
KW - immunization
KW - legislation
KW - smallpox
KW - vaccination
KW - man
KW - Variola virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - adverse reactions
KW - immune sensitization
KW - Laws and Regulations (DD500)
KW - Policy and Planning (EE120)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083152297&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/524381
UR - email: TOverby@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis.
AU - Chumakov, K.
AU - Ehrenfeld, E.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008///
VL - 47
IS - 12
SP - 1587
EP - 1592
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Chumakov, K.: Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike HFM-470, Rockville, MD 20852, USA.
N1 - Accession Number: 20083325905. Publication Type: Journal Article. Language: English. Number of References: 57 ref. Subject Subsets: Public Health
N2 - Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. Although 2 excellent vaccines have proven to be highly effective in the past, neither the live-attenuated vaccine nor the currently used inactivated vaccine are optimal for use in the posteradication era. Therefore, concerted efforts are urgently needed to develop a new generation of vaccine that is risk-free and affordable and can be produced on a global scale. Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine.
KW - human diseases
KW - immunity
KW - immunization
KW - inactivated vaccines
KW - poliomyelitis
KW - vaccination
KW - vaccine development
KW - viral diseases
KW - man
KW - Poliovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - immune sensitization
KW - killed vaccines
KW - polio
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083325905&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/593310
UR - email: konstantin.chumakov@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates.
AU - Selvapandiyan, A.
AU - Duncan, R.
AU - Mendez, J.
AU - Kumar, R.
AU - Salotra, P.
AU - Cardo, L. J.
AU - Nakhasi, H. L.
JO - Transfusion
JF - Transfusion
Y1 - 2008///
VL - 48
IS - 9
SP - 1787
EP - 1798
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Selvapandiyan, A.: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 425, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083306217. Publication Type: Journal Article. Language: English. Number of References: 63 ref. Subject Subsets: Protozoology; Tropical Diseases; Public Health
N2 - BACKGROUND: Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species. STUDY DESIGN AND METHODS: The kinetoplast minicircle DNA is known to have heterogeneity in sequence and is present in many thousands of copies in Leishmania. Fluorescence-based polymerase chain reaction (PCR) was used to amplify minicircle DNA from six Leishmania species from different geographic locations. The sequences were then used to construct a phylogenetic tree. Speciation of 46 blinded parasite clinical isolates from various geographic regions was validated using the assay. RESULTS: Analysis displayed a distinct cluster for each species or strain. Forty-three of 46 isolates were correctly assigned to the same species identified by isoenzyme electrophoresis. The three untyped isolates were all either new species or samples from a unique geographic region. The minicircles of the three isolates formed new clusters in the tree analysis. Using minicircle DNA as PCR target, the sensitivity of the parasite detection in the spiked blood samples was five parasites per mL. CONCLUSION: Increased sensitivity and speciation without the need for parasite culture will be useful for diagnosis and treatment in clinical settings.
KW - analytical methods
KW - assays
KW - blood donors
KW - DNA footprinting
KW - human diseases
KW - leishmaniasis
KW - molecular genetics techniques
KW - performance tests
KW - polymerase chain reaction
KW - Maryland
KW - USA
KW - Leishmania
KW - man
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - leishmaniosis
KW - PCR
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306217&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/fulltext/119880924/HTMLSTART
UR - email: angamuthu.selvapandiyan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.
AU - Mei, N.
AU - Guo, L.
AU - Tseng, J.
AU - Dial, S. L.
AU - Liao, W.
AU - Manjanatha, M. G.
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
Y1 - 2008///
VL - 49
IS - 9
SP - 741
EP - 745
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0893-6692
AD - Mei, N.: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20093040980. Publication Type: Journal Article. Language: English. Registry Number: 9035-51-2, 70-18-8. Subject Subsets: Human Nutrition
N2 - The discovery of acrylamide (AA) in a variety of fried foods has raised public health concerns. In this study, groups of male mice were administered 500 mg/L AA in drinking water for 3 weeks, and gene expression changes were evaluated in the livers of AA-treated mice within 24 hr of the last treatment. When a two-fold cutoff value and a P-value less than 0.05 were selected, 696 genes (233 up-regulated and 463 down-regulated) were identified as differentially expressed genes in AA-treated mice when compared with the controls. Gene ontology analysis revealed that the principle pathways affected by AA were xenobiotic metabolism by cytochrome P450 (CYPs) and glutathione metabolism, suggesting that drug and/or xenobiotic metabolism is most affected by exposure. The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity.
KW - acrylamides
KW - cytochrome P-450
KW - exposure
KW - gene expression
KW - genes
KW - glutathione
KW - laboratory animals
KW - liver
KW - metabolism
KW - molecular genetics
KW - xenobiotics
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093040980&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/121411152/abstract
UR - email: nan.mei@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chikungunya epidemic outbreak in Emilia-Romagna (Italy) during summer 2007.
AU - Angelini, P.
AU - Macini, P.
AU - Finarelli, A. C.
AU - Po, C.
AU - Venturelli, C.
AU - Bellini, R.
AU - Dottori, M.
A2 - Bruschi, F.
A2 - Mancianti, F.
JO - Parassitologia (Roma)
JF - Parassitologia (Roma)
Y1 - 2008///
VL - 50
IS - 1/2
SP - 97
EP - 98
CY - Roma; Italy
PB - Lombardo Editore
SN - 0048-2951
AD - Angelini, P.: Public Health Service of Emilia-Romagna Region, V.le A. Moro, 21 - 40127 Bologna, Italy.
N1 - Accession Number: 20093029708. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 6 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - During summer 2007, an outbreak due to the local transmission of CHIKV by Aedes albopictus mosquitoes occurred in Italy, Emilia-Romagna Region, in the areas of Ravenna, Forlì-Cesena, Rimini and Bologna cities. The original outbreak developed in Castiglione di Cervia and Castiglione di Ravenna, two small villages divided by a river. The first case was recorded on 9th August and the epidemic then spread out, giving rise to smaller secondary outbreaks and further sporadic cases in the same area, for a total of 337 suspected cases, 217 of which were confirmed by blood analysis. CHIKV was isolated and characterized on both blood and mosquito samples.
KW - blood
KW - disease transmission
KW - epidemiology
KW - human diseases
KW - outbreaks
KW - summer
KW - vector-borne diseases
KW - viral diseases
KW - Italy
KW - Aedes albopictus
KW - Chikungunya virus
KW - man
KW - Aedes
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Alphavirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - Asian tiger mosquito
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093029708&site=ehost-live&scope=site
UR - http://www.parassitologia.net/
UR - email: PAngelini@regione.emilia-romagna.it
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The National study to prevent blood exposure in paramedics: exposure reporting.
AU - Boal, W. L.
AU - Leiss, J. K.
AU - Sousa, S.
AU - Lyden, J. T.
AU - Li, J.
AU - Jagger, J.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008///
VL - 51
IS - 3
SP - 213
EP - 222
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Boal, W. L.: Research Epidemiologist Surveillance Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17 Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083166610. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: This survey was conducted to provide national incidence rates and risk factors for exposure to blood among paramedics. The present analysis assesses reporting of exposures to employers. Methods: A questionnaire was mailed in 2002-2003 to a national sample of paramedics selected using a two-stage design. Information on exposure reporting was obtained on the two most recent exposures for each of five routes of exposure. Results: Forty-nine percent of all exposures to blood and 72% of needlesticks were reported to employers. The main reason for under-reporting was not considering the exposure a "significant risk." Females reported significantly more total exposures than males. Reporting of needlesticks was significantly less common among respondents who believed most needlesticks were due to circumstances under the worker's control. Reporting was non-significantly more common among workers who believed reporting exposures helps management prevent future exposures. Reporting may have been positively associated with workplace safety culture. Conclusions: This survey indicates there is need to improve the reporting of blood exposures by paramedics to their employers, and more work is needed to understand the reasons for under-reporting. Gender, safety culture, perception of risk, and other personal attitudes may all affect reporting behavior.
KW - health care workers
KW - human diseases
KW - men
KW - needlestick injuries
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - safety at work
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083166610&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/117891957/abstract?CRETRY=1&SRETRY=0
UR - email: wboal@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silicosis mortality among young adults in the United States, 1968-2004.
AU - Mazurek, J. M.
AU - Attfield, M. D.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008///
VL - 51
IS - 8
SP - 568
EP - 578
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Mazurek, J. M.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Surveillance Branch, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Mailstop HG 900.2, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083269219. Publication Type: Journal Article. Language: English. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - Background - To describe silicosis deaths in young (aged 15-44) adults in the U.S. during 1968-2004. Methods - We analyzed the National Center for Health Statistics multiple cause-of-death records. Results - Compared with silicosis decedents aged ≥45 years (n=15,643), young decedents (n=237) were more likely to have silicosis listed as the underlying cause of death (74.3% vs. 48.2%, P<0.001), to be female (9.3% vs. 2.2%, P<0.001) and black (37.1% vs. 11.7%, P<0.001). Twenty-nine young silicosis decedents had industry and occupation information available. Occupations in construction and manufacturing industries were associated with significantly elevated proportionate mortality ratios for young silicosis deaths. Conclusions - Silicosis deaths occur among young adults. Because these deaths are likely to reflect more intense and recent exposures, the follow-back investigations into the work sites where these individuals were exposed to silica should be conducted.
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupational health
KW - silica
KW - silicosis
KW - young adults
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083269219&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/119755376/abstract
UR - email: acq8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Deaths due to bloodborne infections and their sequelae among health-care workers.
AU - Luckhaupt, S. E.
AU - Calvert, G. M.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008///
VL - 51
IS - 11
SP - 812
EP - 824
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Luckhaupt, S. E.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20083324750. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: The odds of dying from bloodborne infections among health-care workers has not been well studied. Methods: Using data from the National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine the relationship between health-care employment and death from HIV, hepatitis B (HBV), hepatitis C (HCV; non-A/non-B viral hepatitis), liver cancer, and cirrhosis from 1984 to 2004. We examined the whole health-care industry and specific health-care occupations. Results: From 1984 to 2004, NOMS captured 248,550 deaths from bloodborne pathogens and their sequelae. Employment in the health-care industry was associated with increased risk of death from HIV (MOR=2.27; 95% confidence interval [CI]=2.11-2.44), HBV (MOR=1.98; CI=1.58-2.48), and cirrhosis (MOR=1.09; CI=1.04-1.15) among males, and death from HCV among both males (MOR=1.46; CI=1.22-1.75) and females (MOR=1.22; CI=1.05-1.40). Nursing was the occupation with the highest MORs among males for HIV and HBV, but female nurses were at decreased risk of dying from HIV (MOR=0.69; CI=0.57-0.83). Conclusions: Employment in the health-care industry was found to be associated with deaths from several bloodborne pathogens and their sequelae among males, but only with HCV among females from 1984 to 2004 in this exploratory study.
KW - cirrhosis
KW - health care workers
KW - hepatitis B
KW - hepatitis C
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - liver
KW - liver diseases
KW - mortality
KW - non-A, non-B hepatitis
KW - nosocomial infections
KW - nurses
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - viral diseases
KW - viral hepatitis
KW - USA
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - hospital infections
KW - human immunodeficiency virus infections
KW - liver cirrhosis
KW - United States of America
KW - viral infections
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083324750&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/120748293/abstract
UR - email: sluckhaupt@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acute pesticide poisoning among agricultural workers in the United States, 1998-2005.
AU - Calvert, G. M.
AU - Karnik, J.
AU - Mehler, L.
AU - Beckman, J.
AU - Morrissey, B.
AU - Sievert, J.
AU - Barrett, R.
AU - Lackovic, M.
AU - Mabee, L.
AU - Schwartz, A.
AU - Mitchell, Y.
AU - Moraga-McHaley, S.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008///
VL - 51
IS - 12
SP - 883
EP - 898
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0271-3586
AD - Calvert, G. M.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093010156. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Agricultural Engineering
N2 - Background: Approximately 75% of pesticide usage in the United States occurs in agriculture. As such, agricultural workers are at greater risk of pesticide exposure than non-agricultural workers. However, the magnitude, characteristics and trend of acute pesticide poisoning among agricultural workers are unknown. Methods: We identified acute pesticide poisoning cases in agricultural workers between the ages of 15 and 64 years that occurred from 1998 to 2005. The California Department of Pesticide Regulation and the SENSOR-Pesticides program provided the cases. Acute occupational pesticide poisoning incidence rates (IR) for those employed in agriculture were calculated, as were incidence rate ratios (IRR) among agricultural workers relative to non-agricultural workers. Results: Of the 3,271 cases included in the analysis, 2,334 (71%) were employed as farmworkers. The remaining cases were employed as processing/packing plant workers (12%), farmers (3%), and other miscellaneous agricultural workers (19%). The majority of cases had low severity illness (N=2,848, 87%), while 402 (12%) were of medium severity and 20 (0.6%) were of high severity. One case was fatal. Rates of illness among various agricultural worker categories were highly variable but all, except farmers, showed risk for agricultural workers greater than risk for non-agricultural workers by an order of magnitude or more. Also, the rate among female agricultural workers was almost twofold higher compared to males. Conclusion: The findings from this study suggest that acute pesticide poisoning in the agricultural industry continues to be an important problem. These findings reinforce the need for heightened efforts to better protect farmworkers from pesticide exposure.
KW - exposure
KW - pesticides
KW - safety at work
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - agricultural workers
KW - occupational safety
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093010156&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/121356741/abstract
UR - email: jac6@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Monitoring microbial populations on wide-body commercial passenger aircraft.
AU - McKernan, L. T.
AU - Wallingford, K. M.
AU - Hein, M. J.
AU - Burge, H.
AU - Rogers, C. A.
AU - Herrick, R.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2008///
VL - 52
IS - 2
SP - 139
EP - 149
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - McKernan, L. T.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083166413. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health; Leisure, Recreation, Tourism
N2 - Although exposure to bacteria has been assessed in cabin air previously, minimal numbers of samples have been collected in-flight. The purpose of this research was to comprehensively characterize bacterial concentrations in the aircraft cabin. Twelve randomly selected flights were sampled on Boeing-767 aircraft, each with a flight duration between 4.5 and 6.5 h. N-6 impactors were used to collect sequential, triplicate air samples in the front and rear of coach class during six sampling intervals throughout each flight: boarding, mid-climb, early cruise, mid-cruise, late cruise and deplaning. Comparison air samples were also collected inside and outside the airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log-transformed bacterial concentrations. A total of 513 airborne culturable bacterial samples were collected. During flight (mid-climb and cruise intervals), a model-adjusted geometric mean (GM) of 136 total colony-forming units per cubic meter of air sampled (CFU . m-3) and geometric standard deviation of 2.1 were observed. Bacterial concentrations were highest during the boarding (GM 290 CFU . m-3) and deplaning (GM 549 CFU . m-3) processes. Total bacterial concentrations observed during flight were significantly lower than GMs for boarding and deplaning (P values <0.0001-0.021) in the modeled results. Our findings highlight the fact that aerobiological concentrations can be dynamic and underscore the importance of appropriate sample size and design. The genera analysis indicates that passenger activity and high occupant density contribute to airborne bacterial generation. Overall, our research demonstrates that the bacteria recovered on observed flights were either common skin-surface organisms (primarily gram-positive cocci) or organisms common in dust and outdoor air.
KW - air
KW - air microbiology
KW - aircraft
KW - exposure
KW - Gram positive bacteria
KW - bacteria
KW - man
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Tourism and Travel (UU700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083166413&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/
UR - email: lmckernan@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biomarkers of neurotoxic shellfish poisoning.
AU - Abraham, A.
AU - Plakas, S. M.
AU - Flewelling, L. J.
AU - El-Said, K. R.
AU - Jester, E. L. E.
AU - Granade, H. R.
AU - White, K. D.
AU - Dickey, R. W.
JO - Toxicon
JF - Toxicon
Y1 - 2008///
VL - 52
IS - 2
SP - 237
EP - 245
CY - Oxford; UK
PB - Elsevier
SN - 0041-0101
AD - Abraham, A.: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA.
N1 - Accession Number: 20083257323. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) were examined for biomarkers of brevetoxin intoxication. Brevetoxins were concentrated from urine by using solid-phase extraction (SPE), and analyzed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Urine extracts were fractionated by LC, and fractions analyzed for brevetoxins by ELISA. In subsequent LC-MS/MS analyses, several brevetoxin metabolites of B-type backbone were identified, with elution profiles consistent with those of ELISA. The more abundant brevetoxin metabolites in urine were characterized structurally by LC-MS/MS. With the exception of BTX-3, brevetoxin metabolites in urine differed from those found in shellfish and in shellfish meal remnants. Proposed structures of these major urinary metabolites are methylsulfoxy BTX-3, 27-epoxy BTX-3, and reduced BTX-B5. BTX-3 was found in all specimens examined. BTX-3 concentrations in urine, as determined by LC-MS/MS, correlated well with composite toxin measurements by ELISA (r2=0.96). BTX-3 is a useful biomarker for confirmation of clinical diagnosis of NSP.
KW - biochemical markers
KW - diagnosis
KW - diagnostic techniques
KW - disease markers
KW - food poisoning
KW - human diseases
KW - poisoning
KW - shellfish
KW - toxins
KW - urine analysis
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biomarkers
KW - brevetoxin
KW - toxicosis
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083257323&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00410101
UR - email: ann.abraham@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the agricultural health study.
AU - Hines, C. J.
AU - Deddens, J. A.
AU - Jaycox, L. B.
AU - Andrews, R. N.
AU - Striley, C. A. F.
AU - Alavanja, M. C. R.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2008///
VL - 52
IS - 3
SP - 153
EP - 166
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - Hines, C. J.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-14, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083268614. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Registry Number: 133-06-2. Subject Subsets: Agricultural Engineering; Horticultural Science; Plant Pathology
N2 - Pesticide exposure assessment in the Agricultural Health Study (AHS) has relied upon two exposure metrics: lifetime exposure days and intensity-weighted lifetime exposure days, the latter incorporating an intensity score computed from a questionnaire-based algorithm. We evaluated this algorithm using actual fungicide exposure measurements from AHS private orchard applicators. Captan was selected as a marker of fungicide exposure. Seventy-four applicators from North Carolina and Iowa growing apples and/or peaches were sampled on 2 days they applied captan in 2002 and 2003. Personal air, hand rinse, 10 dermal patches, a pre-application first-morning urine and a subsequent 24-h urine sample were collected from each applicator per day. Environmental samples were analyzed for captan, and urine samples were analyzed for cis-1,2,3,6-tetrahydrophthalimide (THPI). Task and personal protective equipment information needed to compute an individual's algorithm score was also collected. Differences in analyte detection frequency were tested in a repeated logistic regression model. Mixed-effects models using maximum-likelihood estimation were employed to estimate geometric mean exposures and to evaluate the measured exposure data against the algorithm. In general, captan and THPI were detected significantly more frequently in environmental and urine samples collected from applicators who used air blast sprayers as compared to those who hand sprayed. The AHS pesticide exposure intensity algorithm, while significantly or marginally predictive of thigh and forearm captan exposure, respectively, did not predict air, hand rinse or urinary THPI exposures. The algorithm's lack of fit with some exposure measures among orchard fungicide applicators may be due in part to the assignment of equal exposure weights to air blast and hand spray application methods in the current algorithm. Some modification of the algorithm is suggested by these results.
KW - algorithms
KW - apples
KW - application methods
KW - applicators
KW - captan
KW - exposure
KW - fungicide residues
KW - fungicides
KW - mathematical models
KW - peaches
KW - Iowa
KW - North Carolina
KW - USA
KW - Malus
KW - Malus domestica
KW - Malus pumila
KW - Prunus persica
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Malus
KW - Prunus
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - Appalachian States of USA
KW - Southern States of USA
KW - South Atlantic States of USA
KW - fungistats
KW - United States of America
KW - Horticultural Crops (FF003) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Agricultural and Forestry Equipment (General) (NN400)
KW - Occupational Health and Safety (VV900)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083268614&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/
UR - email: chines@cde.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens.
AU - Rafii, F.
AU - Park, M.
AU - Bryant, A. E.
AU - Johnson, S. J.
AU - Wagner, R. D.
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
Y1 - 2008///
VL - 52
IS - 3
SP - 895
EP - 900
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0066-4804
AD - Rafii, F.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Adminstration, 3900 NCTR Dr., Jefferson, AR 72079, USA.
N1 - Accession Number: 20083098777. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 9001-86-9, 112811-59-3.
N2 - Clostridium perfringens-induced gas gangrene is mediated by potent extracellular toxins, especially alpha toxin (a phospholipase C [PLC]) and theta toxin (perfringolysin O [PFO], a thiol-activated cytolysin); and antibiotic-induced suppression of toxin synthesis is an important clinical goal. The production of PLC and PFO by a gatifloxacin-induced, fluoroquinolone-resistant mutant strain of C. perfringens, strain 10G, carrying a stable mutation in DNA gyrase was compared with that of the wild-type (WT) parent strain. Zymography (with sheep red blood cell and egg yolk overlays) and time course analysis [with hydrolysis of egg yolk lecithin and O-(4 nitrophenyl-phosphoryl)choline] demonstrated that strain 10G produced more PLC and PFO than the WT strain. Increased toxin production in strain 10G was not related either to differences in growth characteristics between the wild-type and the mutant strain or to nonsynonymous polymorphisms in PLC, PFO, or their known regulatory proteins. Increased PLC and PFO production by strain 10G was associated with increased cytotoxic activity for HT-29 human adenocarcinoma cells and with increased platelet-neutrophil aggregate formation. Four other gatifloxacin-induced gyrase mutants did not show increased toxin production, suggesting that gatifloxacin resistance was not always associated with increased toxin production in all strains of C. perfringens. This is the first report of increased toxin production in a fluoroquinolone-resistant strain of C. perfringens.
KW - animal models
KW - antibacterial agents
KW - bacterial diseases
KW - bacterial toxins
KW - cytotoxicity
KW - erythrocytes
KW - gatifloxacin
KW - human diseases
KW - in vitro
KW - laboratory animals
KW - phospholipase C
KW - Clostridium perfringens
KW - man
KW - sheep
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Ovis
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - blood red cells
KW - red blood cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098777&site=ehost-live&scope=site
UR - http://aac.asm.org/
UR - email: Fatemeh.Rafii@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004.
AU - Cutler, J. A.
AU - Sorlie, P. D.
AU - Wolz, M.
AU - Thom, T.
AU - Fields, L. E.
AU - Roccella, E. J.
JO - Hypertension (Dallas)
JF - Hypertension (Dallas)
Y1 - 2008///
VL - 52
IS - 5
SP - 818
EP - 827
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0194-911X
AD - Cutler, J. A.: National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 6701 Rockledge Dr, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093084553. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This study assesses trends in hypertension prevalence, blood pressure distributions and mean levels, and hypertension awareness, treatment, and control among US adults, age ≥18 years, between the third National Health and Nutrition Examination Survey (1988-1994) and the 1999-2004 National Health and Nutrition Examination Survey, a period of 10 years. The age-standardized prevalence rate increased from 24.4% to 28.9% (P<0.001), with the largest increases among non-Hispanic women. Depending on gender and race/ethnicity, from one fifth to four fifths of the increase could be accounted for by increasing body mass index. Among hypertensive persons, there were modest increases in awareness (P=0.04), from 68.5% to 71.8%. The rate for men increased from 61.6% to 69.3% (P=0.001), whereas the rate for women did not change significantly. Rates remained higher for women than for men, although the difference narrowed considerably. Improvements in treatment and control rates were larger: 53.1% to 61.4% and 26.1% to 35.1%, respectively (both P<0.001). The greatest increases occurred among non-Hispanic white men and non-Hispanic black persons, especially men. Mexican American persons showed improvement in treatment and control rates, but these rates remained the lowest among race/ethnic subgroups (47.4% and 24.3%, respectively). Among all of the race/ethnic groups, women continued to have somewhat better awareness, treatment, and control, except for control rates among non-Hispanic white persons, which became higher in men. Differences between non-Hispanic black and white persons in awareness, treatment, and control were small. These divergent trends may translate into disparate trends in cardiovascular disease morbidity and mortality.
KW - adults
KW - awareness
KW - blacks
KW - blood pressure
KW - body mass index
KW - cardiovascular diseases
KW - disease control
KW - disease prevalence
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - human diseases
KW - hypertension
KW - men
KW - Mexican-Americans
KW - therapy
KW - whites
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - high blood pressure
KW - therapeutics
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093084553&site=ehost-live&scope=site
UR - http://hyper.ahajournals.org/cgi/content/abstract/52/5/818
UR - email: sorliep@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A framework for the concurrent consideration of occupational hazards and obesity.
AU - Schulte, P. A.
AU - Wagner, G. R.
AU - Downes, A.
AU - Miller, D. B.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2008///
VL - 52
IS - 7
SP - 555
EP - 566
CY - Oxford; UK
PB - Oxford University Press
SN - 0003-4878
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083329232. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health; Human Nutrition
N2 - Occupational hazards and obesity can lead to extensive morbidity and mortality and put great financial burden on society. Historically, occupational hazards and obesity have been addressed as separate unrelated issues, but both are public health problems and there may be public health benefits from considering them together. This paper provides a framework for the concurrent consideration of occupational hazards and obesity. The framework consists of the following elements: (i) investigate the relationship between occupational hazards and obesity, (ii) explore the impact of occupational morbidity and mortality and obesity on workplace absence, disability, productivity and healthcare costs, (iii) assess the utility of the workplace as a venue for obesity prevention programs, (iv) promote a comprehensive approach to worker health and (v) identify and address the ethical, legal and social issues. Utilizing this framework may advance the efforts to address the major societal health problems of occupational hazards and obesity.
KW - disabilities
KW - ethics
KW - health care costs
KW - health programs
KW - health services
KW - morbidity
KW - mortality
KW - obesity
KW - occupational hazards
KW - occupational health
KW - reviews
KW - risk
KW - risk factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - fatness
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083329232&site=ehost-live&scope=site
UR - http://annhyg.oxfordjournals.org/
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Herb-drug interactions: theory versus practice.
AU - Cott, J. M.
A2 - Cott, J. M.
T2 - Molecular Nutrition & Food Research
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
Y1 - 2008///
VL - 52
IS - 7
SP - 745
EP - 809
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1613-4125
AD - Cott, J. M.: U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20083212142. Publication Type: Journal issue. Language: English. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science; Human Nutrition
N2 - A series of papers on the topic of herb-drug interactions, specifically the concept that foods and botanical agents could enhance or reduce the effects of prescribed medication, is presented.
KW - drug therapy
KW - food supplements
KW - herbal drugs
KW - nutrient drug interactions
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - herbal medicines
KW - Horticultural Crops (FF003) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Physiology of Human Nutrition (VV120)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083212142&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/109582333/home
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey results of benzene in soft drinks and other beverages by headspace gas chromatography/mass spectrometry.
AU - Nyman, P. J.
AU - Diachenko, G. W.
AU - Perfetti, G. A.
AU - McNeal, T. P.
AU - Hiatt, M. H.
AU - Morehouse, K. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 2
SP - 571
EP - 576
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Nyman, P. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-706, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083061326. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 71-43-2. Subject Subsets: Human Nutrition
N2 - Benzene, a carcinogen that can cause cancer in humans, may form at nanogram per gram levels in some beverages containing both benzoate salts and ascorbic or erythorbic acids. Through a series of reactions, a hydroxyl radical forms that can decarboxylate benzoate to form benzene. Elevated temperatures and light stimulate these reactions, while sugar and ethylenediaminetetraacetic acid (EDTA) can inhibit them. A headspace gas chromatography/mass spectrometry method for the determination of benzene in beverages was developed and validated. The method was used to conduct a survey of 199 soft drinks and other beverages. The vast majority of beverages sampled contained either no detectable benzene or levels below the U.S. Environmental Protection Agency's drinking water limit of 5 ng/g. Beverages found to contain 5 ng/g benzene or more were reformulated by the manufacturers. The amount of benzene found in the reformulated beverages ranged from none detected to 1.1 ng/g.
KW - analytical methods
KW - benzene
KW - beverage quality
KW - beverages
KW - food analysis
KW - food contamination
KW - gas chromatography
KW - mass spectrometry
KW - soft drinks
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - drinks
KW - food contaminants
KW - quality of beverage
KW - United States of America
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083061326&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: Patricia.Nyman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS.
AU - Lopez, M. I.
AU - Pettis, J. S.
AU - Smith, I. B.
AU - Chu, P. S.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 5
SP - 1553
EP - 1559
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Lopez, M. I.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083098872. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Registry Number: 56-75-7, 57-62-5, 64-72-2, 85721-33-1, 91296-86-5, 98106-17-3, 24390-14-5, 10592-13-9, 564-25-0, 93106-60-6, 114-07-8, 23110-15-8, 859-18-7, 154-21-2, 17090-79-8, 79-57-2, 57-92-1, 72-14-0, 60-54-8, 64-75-5, 1401-69-0. Subject Subsets: Human Nutrition; Sugar Industry
N2 - A multiclass method has been developed for the determination and confirmation in honey of tetracyclines (chlortetracycline, doxycycline, oxytetracycline, and tetracycline), fluoroquinolones (ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, and sarafloxacin), macrolides (tylosin), lincosamides (lincomycin), aminoglycosides (streptomycin), sulfonamides (sulfathiazole), phenicols (chloramphenicol), and fumagillin residues using liquid chromatography tandem mass spectrometry (LC-MS/MS). Erythromycin (a macrolide) and monensin (an ionophore) can be detected and confirmed but not quantitated. Honey samples (~2 g) are dissolved in 10 mL of water and centrifuged. An aliquot of the supernatant is used to determine streptomycin. The remaining supernatant is filtered through a fine-mesh nylon fabric and cleaned up by solid phase extraction. After solvent evaporation and sample reconstitution, 15 antibiotics are assayed by LC-MS/MS using electrospray ionization (ESI) in positive ion mode. Afterward, chloramphenicol is assayed using ESI in negative ion mode. The method has been validated at the low part per billion levels for most of the drugs with accuracies between 65 and 104% and coefficients of variation less than 17%. The evaluation of matrix effects caused by honey of different floral origin is presented.
KW - analytical methods
KW - antibiotics
KW - chloramphenicol
KW - chlortetracycline
KW - ciprofloxacin
KW - determination
KW - difloxacin
KW - doxycycline
KW - drug residues
KW - enrofloxacin
KW - erythromycin
KW - fluoroquinolones
KW - fumagillin
KW - honey
KW - lincomycin
KW - liquid chromatography
KW - mass spectrometry
KW - monensin
KW - oxytetracycline
KW - streptomycin
KW - sulfathiazole
KW - techniques
KW - tetracycline
KW - tylosin
KW - achromycin
KW - analytical techniques
KW - aureomycin
KW - lincocin
KW - rumensin
KW - sarafloxacin
KW - sulphathiazole
KW - terramycin
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098872&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: mayda.lopez@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Semicarbazide formation in flour and bread.
AU - Noonan, G. O.
AU - Begley, T. H.
AU - Diachenko, G. W.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 6
SP - 2064
EP - 2067
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Noonan, G. O.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083122314. Publication Type: Journal Article. Language: English. Number of References: 11 ref.
N2 - Azodicarbonamide, an approved food additive, is commonly used as a flour additive and dough conditioner in the United States and Canada. A number of researchers have clearly established a link between the use of azodicarbonamide and semicarbazide contamination in commercial bread products. However, all of these studies have primarily focused on the final baked product and have not extensively investigated the processing and conditions that affect the final semicarbazide levels. In this study, a previously developed method for measuring free semicarbazide in bread was applied to dough samples during the mixing and kneading process. Additionally, flour and bread samples were spiked with biurea or azodicarbonamide to help elucidate semicarbazide formation pathways. The results showed that semicarbazide was not formed as a byproduct of azodicarbonamide decomposition to biurea, which occurs upon the addition of water. Indeed, semicarbazide was not detected after room temperature or elevated temperature dough maturation, but only after baking. It was concluded that although azodicarbonamide is the initial starting material, semicarbazide formation in bread occurs through a stable intermediate, biurea.
KW - bread
KW - doughs
KW - flours
KW - food additives
KW - food contamination
KW - food quality
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - pastry
KW - semicarbazides
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083122314&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: gregory.noonan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry.
AU - Andersen, W. C.
AU - Turnipseed, S. B.
AU - Karbiwnyk, C. M.
AU - Clark, S. B.
AU - Madson, M. R.
AU - Gieseker, C. M.
AU - Miller, R. A.
AU - Rummel, N. G.
AU - Reimschuessel, R.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 12
SP - 4340
EP - 4347
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Andersen, W. C.: Animal Drugs Research Center and Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA.
N1 - Accession Number: 20083265353. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 108-78-1. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology; Pig Science
N2 - Pet and food animal (hogs, chicken, and fish) feeds were recently found to be contaminated with melamine (MEL). A quantitative and confirmatory method is presented to determine MEL residues in edible tissues from fish fed this contaminant. Edible tissues were extracted with acidic acetonitrile, defatted with dichloromethane, and cleaned up using mixed-mode cation exchange solid-phase extraction cartridges. Extracts were analyzed by liquid chromatography with tandem mass spectrometry with hydrophilic interaction chromatography and electrospray ionization in positive ion mode. Fish and shrimp tissues were fortified with 10-500 µg/kg (ppb) of MEL with an average recovery of 63.8% (21.5% relative standard deviation, n=121). Incurred fish tissues were generated by feeding fish up to 400 mg/kg of MEL or a combination of MEL and the related triazine cyanuric acid (CYA). MEL and CYA are known to form an insoluble complex in the kidneys, which may lead to renal failure. Fifty-five treated catfish, trout, tilapia, and salmon were analyzed after withdrawal times of 1-14 days. MEL residues were found in edible tissues from all of the fish with concentrations ranging from 0.011 to 210 mg/kg (ppm). Incurred shrimp and a survey of market seafood products were also analyzed as part of this study.
KW - analytical methods
KW - fish
KW - food contamination
KW - liquid chromatography
KW - mass spectrometry
KW - melamine
KW - seafoods
KW - shrimps
KW - toxic substances
KW - Atlantic salmon
KW - Ictalurus punctatus
KW - Oreochromis
KW - rainbow trout
KW - salmon
KW - trout
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Salmo
KW - Salmonidae
KW - Salmoniformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - diadromous fishes
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Cichlidae
KW - Perciformes
KW - Oncorhynchus
KW - analytical techniques
KW - cyanuric acid
KW - food contaminants
KW - Oncorhynchus mykiss
KW - poisons
KW - Salmo salar
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083265353&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acrylamide: a dietary carcinogen formed in vivo?
AU - Tareke, E.
AU - Lyn-Cook, B.
AU - Robinson, B.
AU - Ali, S. F.
A2 - Mottram, D. S.
A2 - Friedman, M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 15
SP - 6020
EP - 6023
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Tareke, E.: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083281175. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 31 ref. Subject Subsets: Human Nutrition
N2 - Acrylamide, a chemical formed during heating of human foods, reacts with N-terminal valine in hemoglobin (Hb) and forms stable reaction products (adducts). These adducts to N-terminal valine in Hb have been used to estimate daily intake of acrylamide. Daily intake of acrylamide estimated from Hb adduct levels was higher than daily intake estimated from dietary questionnaires, possibly indicating other sources of exposures. Therefore, in this study the possible endogenous formation of acrylamide was investigated by treating mice with FeSO4, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloric acid (MPTP), or methamphetamine (METH). Acrylamide Hb adducts were determined, and a significant increase (p<0.05) in acrylamide Hb adduct levels was observed 24 h following treatment with FeSO4 and 72 h following treatment with MPTP or METH. The results of this study show that acrylamide Hb adduct levels are increased in mice treated with compounds known to induce free radicals, thus suggesting the endogenous production of acrylamide.
KW - acrylamides
KW - animal models
KW - carcinogens
KW - food contamination
KW - laboratory animals
KW - neoplasms
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281175&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: eden.tareke@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity.
AU - Doerge, D. R.
AU - Young, J. F.
AU - Chen, J. J.
AU - DiNovi, M. J.
AU - Henry, S. H.
A2 - Mottram, D. S.
A2 - Friedman, M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 15
SP - 6031
EP - 6038
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Doerge, D. R.: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083281177. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 61 ref. Subject Subsets: Human Nutrition
N2 - The discovery of acrylamide (AA) in many common cooked starchy foods has presented significant challenges to toxicologists, food scientists, and national regulatory and public health organizations because of the potential for producing neurotoxicity and cancer. This paper reviews some of the underlying experimental bases for AA toxicity and earlier risk assessments. Then, dietary exposure modeling is used to estimate probable AA intake in the U.S. population, and physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling is used to integrate the findings of rodent neurotoxicity and cancer into estimates of risks from human AA exposure through the diet. The goal of these modeling techniques is to reduce the uncertainty inherent in extrapolating toxicological findings across species and dose by comparing common exposure biomarkers. PBPK/PD modeling estimated population-based lifetime excess cancer risks from average AA consumption in the diet in the range of 1-4×10-4; however, modeling did not support a link between dietary AA exposure and human neurotoxicity because marginal exposure ratios were 50-300 lower than in rodents. In addition, dietary exposure modeling suggests that because AA is found in so many common foods, even big changes in concentration for single foods or groups of foods would probably have a small impact on overall population-based intake and risk. These results suggest that a more holistic analysis of dietary cancer risks may be appropriate, by which potential risks from AA should be considered in conjunction with other risks and benefits from foods.
KW - acrylamides
KW - animal models
KW - diet
KW - food contamination
KW - human diseases
KW - laboratory animals
KW - neoplasms
KW - neurotoxicity
KW - pharmacodynamics
KW - pharmacokinetics
KW - reviews
KW - risk
KW - risk assessment
KW - toxicity
KW - USA
KW - man
KW - rodents
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - drug action
KW - food contaminants
KW - mechanism of drug action
KW - United States of America
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281177&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: daniel.doerge@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lead in women's and children's vitamins.
AU - Mindak, W. R.
AU - Cheng, J.
AU - Canas, B. J.
AU - Bolger, P. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 16
SP - 6892
EP - 6896
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Mindak, W. R.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration 5100 Paint Branch Parkway, Mail Stop HFS-716, College Park, MD 20740, USA.
N1 - Accession Number: 20083281213. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 7439-92-1. Subject Subsets: Human Nutrition; Public Health
N2 - A survey was conducted to determine the extent of lead (Pb) contamination in vitamins labeled for use by women and children. The Pb content of 324 multivitamin - mineral products was determined using microwave assisted nitric acid digestion and inductively coupled plasma mass spectrometry. Cryogenic grinding was used to composite soft samples such as oil filled capsules and candy-like products such as gummies and jelly beans. Estimates of Pb exposures from consumption of these products were derived for four population groups: young children (0-6 yrs), older children (7+ yrs), pregnant or lactating women, and adult women. The estimated median and maximum Pb exposures were 0.123 and 2.88 µg/day for young children, 0.356 and 1.78 µg/day for older children, 0.845 and 8.97 µg/day for pregnant and lactating women, and 0.842 and 4.92 µg/day for adult women. The overall median value for Pb exposure was 0.576 µg/day. Five samples would have provided exposures that exceeded 4 µg/day. Estimates of exposures were assessed with respect to safe/tolerable exposure levels that have been developed for the specific age and sex groups. These safe/tolerable levels are referred to as the provisional total tolerable intake levels (PTTI) and are 6, 15, 25, and 75 µg Pb/day for young children, older children, pregnant or lactating women, and adult women, respectively. Estimates of Pb exposures were below the PTTI levels for the four population groups. Median and maximum values were used instead of the mean and standard deviation because of the skewed distribution of results toward lower mass fraction and exposure.
KW - children
KW - food contamination
KW - lead
KW - vitamin supplements
KW - vitamins
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - food contaminants
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Physiology of Human Nutrition (VV120)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281213&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: william.mindak@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Residue depletion of nitrofuran drugs and their tissue-bound metabolites in channel catfish (Ictalurus punctatus) after oral dosing.
AU - Chu, P. S.
AU - Lopez, M. I.
AU - Abraham, A.
AU - El-Said, K. R.
AU - Plakas, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2008///
VL - 56
IS - 17
SP - 8030
EP - 8034
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Chu, P. S.: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083281142. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 139-91-1, 67-45-8, 59-87-0, 67-20-9. Subject Subsets: Veterinary Science; Veterinary Science
N2 - The depletion of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin and their tissue-bound metabolites [3-amino-2-oxazolidinone (AOZ), semicarbazide (SC), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), and 1-aminohydantoin (AH), respectively] were examined in the muscle of channel catfish following oral dosing (1 mg/kg body weight). Parent drugs were measurable in muscle within 2 h. Peak levels were found at 4 h for furazolidone (30.4 ng/g) and at 12 h for nitrofurazone, furaltadone, and nitrofurantoin (104, 35.2, and 9.8 ng/g respectively). Parent drugs were rapidly eliminated from muscle, and tissue concentrations fell below the limit of detection (1 ng/g) at 96 h. Peak levels of tissue-bound AMOZ and AOZ (46.8 and 33.7 ng/g respectively) were measured at 12 h, and of SC and AH (31.1 and 9.1 ng/g, respectively) at 24 h. Tissue-bound metabolites were measurable for up to 56 days postdose. These results support the use of tissue-bound metabolites as target analytes for monitoring nitrofuran drugs in channel catfish.
KW - antiinfective agents
KW - depletion
KW - drug excretion
KW - drug residues
KW - furaltadone
KW - furazolidone
KW - metabolites
KW - monitoring
KW - nitrofural
KW - nitrofurans
KW - nitrofurantoin
KW - oral administration
KW - tissue distribution
KW - Ictalurus punctatus
KW - Ictalurus
KW - Ictaluridae
KW - Siluriformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - antimicrobials
KW - nitrofurazone
KW - surveillance systems
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281142&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: pak.chu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Commercial fishing fatalities - California, Oregon, and Washington, 2000-2006.
AU - Lincoln, J.
AU - Lucas, D.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2008///
VL - 57
IS - 16
SP - 425
EP - 429
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Lincoln, J.: Alaska Pacific Regional Office, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20083147306. Publication Type: Journal Article. Language: English. Number of References: 4 ref. Subject Subsets: Public Health
N2 - This article presents an investigation conducted by the Centers for Disease Control and Prevention (CDC) to determine the commercial fishing fatalities in California, Oregon, and Washington (USA) during the 2000-2006 period. The 3 states combined had an average annual commercial fishing fatality rate of 238 deaths per 100 000 full-time equivalent (FTE) fishermen, approximately double the fishing fatality rate nationwide during the same period. CDC also determined that safety equipment (e.g., immersion suits or life rafts) had not been used adequately in these fatal events, and that the Northwest Dungeness crab fishery had the highest fatality rate of any fishery located off the coasts of California, Oregon, and Washington. To reduce fatalities among the Pacific Coast commercial fishermen at greatest risk, additional prevention measures tailoured to the Northwest Dungeness crab fishery should be considered.
KW - accidents
KW - death
KW - epidemiology
KW - fishermen
KW - fishing
KW - human diseases
KW - mortality
KW - occupational hazards
KW - safety at work
KW - California
KW - Oregon
KW - USA
KW - Washington
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Pacific Northwest States of USA
KW - death rate
KW - occupational safety
KW - United States of America
KW - Fisheries (MM110)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083147306&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Fatalities among oil and gas extraction workers - United States, 2003-2006.
AU - Mode, N. A.
AU - Conway, G. A.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2008///
VL - 57
IS - 16
SP - 429
EP - 431
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Mode, N. A.: Alaska Pacific Regional Office, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20083147307. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This article presents a retrospective analysis (by the Centers for Disease Control and Prevention) of the data obtained from the Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries (CFOI) for the period 2003-2006. Analysis showed that increases in oil and gas extraction activity were correlated with an increase in the rate of fatal occupational injuries in this industry, with an annual fatality rate of 30.5 per 100 000 workers (404 fatalities) during 2003-2006, approximately 7 times the rate for all workers (4.0 per 100 000 workers). Nearly half of all fatal injuries among these workers were attributed to highway motor vehicle crashes and workers being struck by machinery or equipment. Employers should work with existing industry groups and federal, state, and local government agencies to promote seatbelt use. In addition, researchers and public health officials should collaborate with industry groups to establish engineering and process controls that remove workers from potentially dangerous machinery while drilling and servicing oil and gas wells.
KW - adults
KW - death
KW - epidemiology
KW - human diseases
KW - industrial workers
KW - mortality
KW - occupational hazards
KW - occupational health
KW - petrochemical workers
KW - traffic accidents
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083147307&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Syncope after vaccination - United States, January 2005-July 2007.
AU - Sutherland, A.
AU - Izurieta, H.
AU - Ball, R.
AU - Braun, M. M.
AU - Miller, E. R.
AU - Broder, K. R.
AU - Slade, B. A.
AU - Iskander, J. K.
AU - Kroger, A. T.
AU - Markowitz, L. E.
AU - Huang, W. T.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2008///
VL - 57
IS - 17
SP - 457
EP - 460
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Sutherland, A.: Div of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Admin, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20083147312. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - To describe trends in occurrence of postvaccination syncope, the Centers for Disease Control and Prevention and the Food and Drug Administration analysed data from the Vaccine Adverse Event Reporting System (VAERS) for the period, 1 January 2005-31 July 2007, and compared the results with VAERS reports received during 1 January 2002-31 December 2004. Since 2005, reports to VAERS regarding postvaccination syncope have increased, primarily among females aged 11-18 years, and rarely, subsequent serious injuries have occurred. To prevent syncope-related injuries, vaccine providers should follow the ACIP recommendation to strongly consider observing patients for 15 minutes after vaccination.
KW - adverse effects
KW - disease incidence
KW - human diseases
KW - immunization
KW - vaccination
KW - vaccines
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - immune sensitization
KW - syncope
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083147312&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Silicosis-related years of potential life lost before age 65 years - United States, 1968-2005.
AU - Mazurek, J. M.
AU - Wood, J. M.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2008///
VL - 57
IS - 28
SP - 771
EP - 775
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Mazurek, J. M.: Div Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20083229160. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 7631-86-9. Subject Subsets: Public Health
N2 - This paper describes the trends in premature mortality attributed to silicosis, based on years of potential life lost before age 65 years (YPLL), in the USA, during 1968-2005. Data showed that the total annual YPLL attributed to silicosis decreased by 90.2%, from 1441 (mean per decedent: 7.7 YPLL) in 1968 to 141 (mean per decedent: 11.8) in 2005, with an annual average of 8.6 YPLL per decedent for the period. However, the proportion of YPLL attributable to young silicosis decedents increased, with an estimated 3600-7300 new silicosis cases occurring annually. Industry or occupation information was available for 148 (39.6%) of 374 decedents aged 15-64 years whose deaths were attributed to silicosis during 1985-1999. Of 46 industries reported, the greatest YPLL were in construction (263; mean per decedent: 10.1 YPLL), iron and steel foundries (131; mean per decedent: 10.9), and blast furnaces, steelworks, rolling and finishing mills (97; mean per decedent: 10.8). Among 53 occupations reported, the greatest YPLL were for miscellaneous metal and plastic processing machine operators (174; mean per decedent: 21.8 YPLL), labourers except construction (120; mean per decedent: 12), and mining machine operators (113; mean per decedent: 5.4). It is suggested that hazard surveillance, workplace-specific interventions and further silicosis prevention and elimination efforts, especially among young adults, are needed.
KW - epidemiology
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupational health
KW - occupations
KW - respiratory diseases
KW - silica
KW - silicosis
KW - trends
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - lung diseases
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083229160&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Asbestosis-related years of potential life lost before age 65 years - United States, 1968-2005.
AU - Mazurek, J. M.
AU - Wood, J. M.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2008///
VL - 57
IS - 49
SP - 1321
EP - 1325
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Mazurek, J. M.: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20093016185. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - In a review of relevant epidemiological data on asbestosis-related mortality in the USA during the period 1968-2005, it was shown that asbestosis was identified as the underlying cause of death for 9024 decedents. Of these, 1169 (13%) were aged 25-64 years, which accounted for 7267 years of potential life lost (YPLL) before age 65 years. The majority of asbestosis decedents aged 25-64 years were male (n=1125, 96.2%) and white (n=1064, 91%), which accounted for 7038 and 6470 YPLL, respectively. The YPLL attributed to asbestosis deaths increased 64%, from an average of 146.0 per year during 1968-72 to 239.6 per year during 2001-05 (regression trend, p<0.001). The YPLL varied annually, from a low of 69 (mean per decedent, 8.6) in 1973 to a high of 306 (mean per decedent, 5.9) in 1990. Industry and occupation information was available for 153 (28.8%) of the 531 decedents aged 25-64 years with asbestosis as the underlying cause of death during 1985-99. Of the 54 industries reported, the greatest YPLL were in construction (244 YPLL), ship and boat building and repairing (41 YPLL), and in the military (41 YPLL). Of the 59 occupations reported, the greatest YPLL were for insulation workers (112 YPLL), managers and administrators (43 YPLL), and plumbers/pipefitters/steamfitters (42 YPLL).
KW - asbestosis
KW - causes of death
KW - demography
KW - epidemiology
KW - human diseases
KW - industrial workers
KW - mortality
KW - occupational hazards
KW - occupational health
KW - occupations
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - United States of America
KW - Demography (UU200)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093016185&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The suicide mortality of working physicians and dentists.
AU - Petersen, M. R.
AU - Burnett, C. A.
JO - Occupational Medicine (Oxford)
JF - Occupational Medicine (Oxford)
Y1 - 2008///
VL - 58
IS - 1
SP - 25
EP - 29
CY - Oxford; UK
PB - Oxford University Press
SN - 0962-7480
AD - Petersen, M. R.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20083070111. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Some studies have shown that physicians and dentists have elevated risks of suicide, while other studies have not. Aims: Using all deaths and corresponding census data in 26 US states, we examine the suicide risk for working physicians and dentists. Methods: Death and census data for working people were obtained from 1984 through 1992. Directly age-standardized suicide rate ratios (SRRs) were calculated for white male and white female physicians and white male dentists. Results: For white female physicians, the suicide rate was elevated compared to the working US population (SRR=2.39, 95% CI=1.52-3.77). For white male physicians and dentists, the overall suicide rates were reduced (SRR=0.80, 95% CI=0.53-1.20 and 0.68, 95% CI=0.52-0.89, respectively). For older white male physicians and dentists, however, observed suicide rates were elevated. Conclusions: White female physicians have an elevated suicide rate. Only older white male physicians and dentists have elevated suicide rates, which partially explains the varied conclusions in the literature.
KW - death
KW - dentists
KW - mortality
KW - occupational health
KW - physicians
KW - suicide
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - doctors
KW - United States of America
KW - Professions: Practice and Service (CC700)
KW - Conflict (UU495) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083070111&site=ehost-live&scope=site
UR - http://occmed.oxfordjournals.org/cgi/content/abstract/58/1/25
UR - email: mrp1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An intrinsic pattern of reduced susceptibility to fluoroquinolones in pediatric isolates of Streptococcus pyogenes.
AU - Yan, S. S.
AU - Schreckenberger, P. C.
AU - Zheng, X. T.
AU - Nelson, N. A.
AU - Harrington, S. M.
AU - Tjhio, J.
AU - Fedorko, D. P.
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
Y1 - 2008///
VL - 62
IS - 2
SP - 205
EP - 209
CY - New York; USA
PB - Elsevier
SN - 0732-8893
AD - Yan, S. S.: Food and Drug Administration, DHHS, Rockville, MD 20855, USA.
N1 - Accession Number: 20093017249. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 85721-33-1, 100986-85-4, 151096-09-2. Subject Subsets: Public Health
N2 - A total of 116 clinical isolates collected in 2003 from a tertiary pediatric hospital and a primary pediatric department in Chicago, IL, were screened for reduced susceptibility to selected fluoroquinolones by disc diffusion. Correlation between reduced susceptibility and point mutations in the quinolone resistance-determining region of parC and gyrA genes was evaluated, and point mutations were compared with other reports of isolates derived from adult or mixed patient populations. Nine percent of isolates had reduced susceptibility to 1 or more of these fluoroquinolones by Etest: ciprofloxacin, levofloxacin, and moxifloxacin. A single point mutation (Ser-79) in parC seemed responsible for the reduced susceptibility. Resistant Streptococcus pyogenes isolates were compared using M/emm type, repetitive sequence-based PCR (rep-PCR), and pulsed-field gel electrophoresis (PFGE). Rep-PCR provided no more separation of strains than M/emm typing, and PFGE results with SgrAI were more discriminatory than with SmaI. The majority of these isolates were M/emm type 6. PFGE analysis using SgrAI demonstrated 2 different resistant strains among the M/emm type 6 isolates. The findings suggest that a population of S. pyogenes with an intrinsic reduced susceptibility to fluoroquinolones exists in pediatric clinical isolates. Monitoring of amino acid changes in both parC and gyrA will assist in the prediction of emergence of high-level fluoroquinolone resistance.
KW - antibacterial agents
KW - bacterial diseases
KW - children
KW - ciprofloxacin
KW - drug resistance
KW - drug susceptibility
KW - fluoroquinolones
KW - genes
KW - human diseases
KW - levofloxacin
KW - moxifloxacin
KW - mutations
KW - Illinois
KW - USA
KW - man
KW - Streptococcus pyogenes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093017249&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T60-4SRDF8J-1&_user=6686535&_coverDate=10%2F31%2F2008&_rdoc=14&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235016%232008%23999379997%23698002%23FLA%23display%23Volume)&_cdi=5016&_sort=d&_docanchor=&_ct=19&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=34488936ad7a798bd6630741e272b0bd
UR - email: dfedorko@mail.cc.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - To ban or not to ban - that is the question: the constitutionality of a moratorium on consumer drug advertising.
AU - Schwartz, M. I.
JO - Food and Drug Law Journal
JF - Food and Drug Law Journal
Y1 - 2008///
VL - 63
IS - 1
SP - 1
EP - 34
CY - Washington; USA
PB - Food and Drug Law Institute
SN - 1064-590X
AD - Schwartz, M. I.: Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20083280365. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - In September 2006, the Institute of Medicine, part of the National Academy of Sciences, released a report on drug safety, commissioned by the Food and Drug Administration, arguing that the agency be given the power to impose a two-year moratorium on direct-to-consumer (DTC) advertisements. In 2007, bills were introduced in both houses of Congress empowering the Secretary of Health and Human Services to impose moratoria on DTC advertising for certain newly approved drugs. Although these bills were not incorporated into the Food and Drug Administration Amendments Act of 2007, there remains significant support for a new-drug moratorium on Capitol Hill, and among interest groups, medical organizations, a majority of physicians and at least one presidential candidate. The United States remains one of only two countries in the Organization for Economic Cooperation and Development that allows DTC advertising of prescription drugs. As a result, there is a real possibility that a future Congress will pass, and a president will sign, legislation imposing some sort of moratorium on DTC drug advertising. This article considers whether these, or any similar bills, would be constitutionally valid under the First Amendment.
KW - advertising
KW - drugs
KW - law
KW - legislation
KW - safety
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - legal aspects
KW - legal principles
KW - medicines
KW - pharmaceuticals
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Marketing and Distribution (EE700)
KW - Communication and Mass Media (UU360)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083280365&site=ehost-live&scope=site
UR - http://www.fdli.org/pubs/Journal%20Online/jour_toc/vol63_1.html
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Clostridium difficile: from obscurity to superbug.
AU - Brazier, J. S.
T2 - British Journal of Biomedical Science
JO - British Journal of Biomedical Science
JF - British Journal of Biomedical Science
Y1 - 2008///
VL - 65
IS - 1
SP - 39
EP - 44
CY - Tunbridge Wells; UK
PB - Step Publishing Limited
SN - 0967-4845
AD - Brazier, J. S.: Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology, Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK.
N1 - Accession Number: 20083188832. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Public Health
N2 - This review article provides a brief historical account of how C. difficile was recognized as a pathogen, discusses challenges in the diagnosis of C. difficile, describes typing methods developed to understand the epidemiology of C. difficile infection, presents results of the national surveillance of C. difficile strains causing disease, and provides evidence of the association of PCR ribotype 027 with severity of C. difficile infection.
KW - bacterial diseases
KW - diagnosis
KW - epidemiology
KW - human diseases
KW - methodology
KW - reviews
KW - surveillance
KW - Clostridium difficile
KW - man
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - methods
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083188832&site=ehost-live&scope=site
UR - http://www.bjbs-online.org/
UR - email: brazier@cardiff.ac.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surrogate endpoints and emerging surrogate endpoints for risk reduction of cardiovascular disease.
AU - Rasnake, C. M.
AU - Trumbo, P. R.
AU - Heinonen, T. M.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008///
VL - 66
IS - 2
SP - 76
EP - 81
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0029-6643
AD - Rasnake, C. M.: Nutrition Programs Staff, US Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20083092071. Publication Type: Journal Article. Language: English. Number of References: 70 ref. Registry Number: 57-88-5. Subject Subsets: Human Nutrition; Public Health
N2 - This article reviews surrogate endpoints and emerging biomarkers that were discussed at the annual "Cardiovascular Biomarkers and Surrogate Endpoints" symposium cosponsored by the US Food and Drug Administration (FDA) and the Montreal Heart Institute. The FDA's Center for Food Safety and Applied Nutrition (CFSAN) uses surrogate endpoints in its scientific review of a substance/disease relationship for a health claim. CFSAN currently recognizes three validated surrogate endpoints: blood pressure, blood total cholesterol, and blood low-density lipoprotein (LDL) concentration in its review of a health claim for cardiovascular disease (CVD). Numerous potential surrogate endpoints of CVD are being evaluated as the pathophysiology of heart disease is becoming better understood. However, these emerging biomarkers need to be validated as surrogate endpoints before they are used by CFSAN in the evaluation of a CVD health claim.
KW - blood lipids
KW - blood pressure
KW - cardiovascular diseases
KW - cholesterol
KW - disease markers
KW - human diseases
KW - human nutrition research
KW - low density lipoprotein
KW - pathogenesis
KW - reviews
KW - risk factors
KW - risk reduction
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083092071&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1753-4887.2007.00010.x
UR - email: crystal.rasnake@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Challenges with using chronic disease endpoints in setting dietary reference intakes.
AU - Trumbo, P. R.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008///
VL - 66
IS - 8
SP - 459
EP - 464
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0029-6643
AD - Trumbo, P. R.: Division of Nutrition Programs and Labeling, U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20083283116. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Human Nutrition
N2 - Since 1941, the recommended dietary allowances (RDAs) in the United States have been based on the goal of maintaining health in the country's population. There has been a growing body of evidence to support the role of diet in reducing the risk of chronic diseases. For this reason, there has been recent emphasis on considering data on chronic disease endpoints for setting dietary reference intakes (DRIs). Despite this emphasis, none of the RDAs set during the DRI review were based on chronic disease risk. However, chronic disease risk was considered for determining adequate intakes and even some acceptable macronutrient distribution ranges. This article discusses the application of and challenges associated with using chronic disease endpoints in setting DRIs.
KW - diets
KW - estimation
KW - health
KW - macronutrients
KW - recommended dietary allowances
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - RDA
KW - recommended dietary intakes
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083283116&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/nure
UR - email: paula.trumbo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.
AU - Pogribny, I. P.
AU - Tryndyak, V. P.
AU - Ross, S. A.
AU - Beland, F. A.
A2 - Ross, S. A.
A2 - Dwyer, J.
A2 - Umar, A.
A2 - Kagan, J.
A2 - Verna, M.
A2 - van Bemmel, D. M.
A2 - Dunn, B. K.
T3 - Special Issue: Diet, epigenetic events, and cancer prevention.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008///
VL - 66
IS - s1
SP - S33
EP - S35
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0029-6643
AD - Pogribny, I. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083283103. Publication Type: Journal Article. Note: Special Issue: Diet, epigenetic events, and cancer prevention. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
KW - animal models
KW - deficiency
KW - liver cancer
KW - models
KW - neoplasms
KW - nutrition
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083283103&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/nure
UR - email: igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Extended-spectrum β-lactamase (ESBL)-producing enterobacteria: factors associated with infection in the community setting, Auckland, New Zealand.
AU - Moor, C. T.
AU - Roberts, S. A.
AU - Simmons, G.
AU - Briggs, S.
AU - Morris, A. J.
AU - Smith, J.
AU - Heffernan, H.
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
Y1 - 2008///
VL - 68
IS - 4
SP - 355
EP - 362
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0195-6701
AD - Moor, C. T.: Auckland Regional Public Health Service, Private Bag 92 605, Symond Street, Auckland 1035, New Zealand.
N1 - Accession Number: 20083125327. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9001-74-5. Subject Subsets: Public Health
N2 - We aimed to document the epidemiology of extended-spectrum β-lactamase (ESBL)-producing enterobacteria in the Auckland community and identify factors associated with infection using a case-control study design. ESBL-producing enterobacteria were isolated from 107 infected patients, for which demographic and clinical data were available for 98 cases (92%). Escherichia coli was the predominant organism (82%), with urine as the commonest source (97%). Compared with a control group infected with ESBL-negative enterobacteria, factors significantly associated with infection on univariate analysis were: living in a residential care home (RCH); recent admission to hospital 'M'; recent antibiotic use; older age (>75 years); presence of a urinary catheter; and a history of comorbid chronic obstructive pulmonary disease (COPD), cardiovascular disease, neurological disease or recurrent urinary tract infection. On multivariate analysis, residence in RCH and COPD remained significant associations. Pulsed-field gel electrophoresis typing of the ESBL-producing E. coli identified a common strain. We concluded that residence in RCH and a history of COPD are significant associations with ESBL-producing enterobacterial infection in the Auckland community. Several spatial clusters in RCHs and a common strain suggest point-source outbreaks. A substantial number of community cases did not live in an RCH nor had been recently hospitalised, suggesting the independent generation of ESBL-producing enterobacteria in the broader community.
KW - aetiology
KW - age
KW - bacterial diseases
KW - beta-lactamase
KW - chronic obstructive pulmonary disease
KW - disease prevalence
KW - epidemiology
KW - home care
KW - human diseases
KW - morbidity
KW - respiratory diseases
KW - risk factors
KW - New Zealand
KW - Enterobacteriaceae
KW - Escherichia coli
KW - man
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - Enterobacteriaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - causal agents
KW - E. coli
KW - etiology
KW - lung diseases
KW - penicillinase
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083125327&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01956701
UR - email: gregs@adhb.govt.nz
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Web-based reporting of the results of the 2006 Four Country Prevalence Survey of Healthcare Associated Infections.
AU - Harris, S.
AU - Morgan, M.
AU - Davies, E.
T3 - Special Edition: Surveillance of hospital acquired infection.
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
Y1 - 2008///
VL - 69
IS - 3
SP - 258
EP - 264
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0195-6701
AD - Harris, S.: Welsh Healthcare Associated Infection Programme (WHAIP), National Public Health Service, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK.
N1 - Accession Number: 20083228594. Publication Type: Journal Article. Note: Special Edition: Surveillance of hospital acquired infection. Language: English. Number of References: 7 ref. Subject Subsets: Public Health
N2 - A web-base reporting system was developed in order to feed back the results of the 2006 prevalence survey of healthcare-associated infections in a timely manner to all participating hospitals in England, Wales and Northern Ireland. The database accommodated ~75 000 records from over 250 hospitals. The reporting system was hosted on the National Health Service intranet, accessible via secure login. Users were able to access their individual Trust data via a series of predefined reports and an export facility was included to facilitate additional analysis. The reporting system was made available to participating hospitals within 12 months of completion of the survey. From the results of a user satisfaction survey, end-users responded positively to receiving feedback in this format. It serves as a useful model for the feedback of results for future prevalence surveys.
KW - data collection
KW - disease prevalence
KW - health care
KW - human diseases
KW - internet
KW - nosocomial infections
KW - England
KW - Irish Republic
KW - Northern Ireland
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - data logging
KW - Eire
KW - hospital infections
KW - United Kingdom
KW - Information and Documentation (CC300)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083228594&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01956701
UR - email: susan.harris@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of Escherichia coli O157:H7 enrichment in spiked produce samples.
AU - Grant, M. A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 1
SP - 139
EP - 145
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Grant, M. A.: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Bothell, WA 98021, USA.
N1 - Accession Number: 20083044965. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Postharvest Research
N2 - Two strains of Escherichia coli O157:H7 were spiked into six varieties of produce at approximately 0.5 CFU g-1. Samples were enriched by using the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) method and by using an experimental method incorporating acid shock. Target colonies were detectable on selective agars after 30 of 48 analyses with BAM enrichment and 48 of 48 analyses with acid enrichment. Real-time PCR screening of 24-h enrichment broths revealed the presence of the diagnostic stx1 or stx2 genes after 27 of 48 analyses with BAM enrichment and 42 of 48 analyses with acid enrichment. The efficiency of the enrichment varied with strain and type of produce spiked but overall was better with the experimental enrichment method. Modifications of both the acid enrichment and BAM enrichment methods also were tested. The acid method with a modified incubation temperature consistently yielded high rates of recovery (>108 CFU ml-1), with no instances in which target cells could not be detected. Modification of the BAM procedure did not reproducibly improve enrichment efficiency.
KW - acid treatment
KW - analytical methods
KW - culture media
KW - detection
KW - DNA sequencing
KW - enrichment
KW - food contamination
KW - food processing
KW - genes
KW - microbial contamination
KW - strains
KW - vegetables
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - E. coli
KW - food contaminants
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - vegetable crops
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044965&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: mike.grant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Potential use of DNA barcodes in regulatory science: applications of the Regulatory Fish Encyclopedia.
AU - Yancy, H. F.
AU - Zemlak, T. S.
AU - Mason, J. A.
AU - Washington, J. D.
AU - Tenge, B. J.
AU - Nguyen, N. L. T.
AU - Barnett, J. D.
AU - Savary, W. E.
AU - Hill, W. E.
AU - Moore, M. M.
AU - Fry, F. S.
AU - Randolph, S. C.
AU - Rogers, P. L.
AU - Hebert, P. D. N.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 1
SP - 210
EP - 217
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Yancy, H. F.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083044978. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9007-43-6, 9007-49-2. Subject Subsets: World Agriculture, Economics & Rural Sociology; Agricultural Biotechnology; Human Nutrition
N2 - The use of a DNA-based identification system (DNA barcoding) founded on the mitochondrial gene cytochrome c oxidase subunit I (COI) was investigated for updating the U.S. Food and Drug Administration Regulatory Fish Encyclopedia (RFE; http://www.cfsan.fda.gov/~frf/rfe0.html). The RFE is a compilation of data used to identify fish species. It was compiled to help regulators identify species substitution that could result in potential adverse health consequences or could be a source of economic fraud. For each of many aquatic species commonly sold in the United States, the RFE includes high-resolution photographs of whole fish and their marketed product forms and species-specific biochemical patterns for authenticated fish species. These patterns currently include data from isoelectric focusing studies. In this article, we describe the generation of DNA barcodes for 172 individual authenticated fish representing 72 species from 27 families contained in the RFE. These barcode sequences can be used as an additional identification resource. In a blind study, 60 unknown fish muscle samples were barcoded, and the results were compared with the RFE barcode reference library. All 60 samples were correctly identified to species based on the barcoding data. Our study indicates that DNA barcoding can be a powerful tool for species identification and has broad potential applications.
KW - cytochrome c
KW - databases
KW - DNA
KW - DNA sequencing
KW - fish
KW - genetic analysis
KW - identification
KW - labelling
KW - molecular genetics techniques
KW - oxidoreductases
KW - species
KW - techniques
KW - data banks
KW - deoxyribonucleic acid
KW - labeling
KW - labels
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - redox enzymes
KW - Information and Documentation (CC300)
KW - Marketing and Distribution (EE700)
KW - Aquatic Biology and Ecology (MM300)
KW - Aquatic Produce (QQ060)
KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044978&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: haile.yancy@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cleaning and other control and validation strategies to prevent allergen cross-contact in food-processing operations.
AU - Jackson, L. S.
AU - Al-Taher, F. M.
AU - Moorman, M.
AU - DeVries, J. W.
AU - Tippett, R.
AU - Swanson, K. M. J.
AU - Fu, T. J.
AU - Salter, R.
AU - Dunaif, G.
AU - Estes, S.
AU - Albillos, S.
AU - Gendel, S. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 2
SP - 445
EP - 458
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jackson, L. S.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20083061224. Publication Type: Journal Article. Language: English. Number of References: 61 ref.
N2 - Food allergies affect an estimated 10 to 12 million people in the United States. Some of these individuals can develop life-threatening allergic reactions when exposed to allergenic proteins. At present, the only successful method to manage food allergies is to avoid foods containing allergens. Consumers with food allergies rely on food labels to disclose the presence of allergenic ingredients. However, undeclared allergens can be inadvertently introduced into a food via cross-contact during manufacturing. Although allergen removal through cleaning of shared equipment or processing lines has been identified as one of the critical points for effective allergen control, there is little published information on the effectiveness of cleaning procedures for removing allergenic materials from processing equipment. There also is no consensus on how to validate or verify the efficacy of cleaning procedures. The objectives of this review were (i) to study the incidence and cause of allergen cross-contact, (ii) to assess the science upon which the cleaning of food contact surfaces is based, (iii) to identify best practices for cleaning allergenic foods from food contact surfaces in wet and dry manufacturing environments, and (iv) to present best practices for validating and verifying the efficacy of allergen cleaning protocols.
KW - allergens
KW - cleaning
KW - decontamination
KW - food allergies
KW - food contamination
KW - food hygiene
KW - food inspection
KW - food processing
KW - food safety
KW - foods
KW - quality controls
KW - surfaces
KW - systematic reviews
KW - food contaminants
KW - food hypersensitivity
KW - quality assurance
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083061224&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: lauren.jackson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of melamine using commercial enzyme-linked immunosorbent assay technology.
AU - Garber, E. A. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 3
SP - 590
EP - 594
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Garber, E. A. E.: Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20083098923. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Registry Number: 108-78-1. Subject Subsets: Animal Nutrition; Human Nutrition
N2 - Recent cases of adulteration with melamine have led to the need for rapid and reliable screening methods. To meet this need, commercial enzyme-linked immunosorbent assay (ELISA) test kits for the detection of triazines were evaluated. The recently released Melamine Plate kit (Abraxis, Warminster, Pa.) displayed a limit of detection of 9 ng/ml for melamine in phosphate-buffered saline (PBS) and approximately 1 µg/ml for melamine added to dog food. An atrazine ELISA test kit produced by Abraxis required 0.2 mg/ml to generate a response more than four times the standard deviation from background. In contrast, with the EnviroGard Triazine Plate kit (Strategic Diagnostics, Inc., Newark, Del.), 1.5 mg/ml melamine in PBS generated a signal only one standard deviation from background, which was insufficient to define a limit of detection. Extraction based on dilution with 105 mM sodium phosphate/75 mM NaCl/2.5% nonfat milk/0.05% Tween 20 (UD) enabled detection of fivefold less melamine in dog food than did use of the procedure recommended by the manufacturer, which entailed extraction into 60% methanol, sonication, centrifugation, filtration, and further dilution into 10% methanol/PBS. Using the Abraxis Melamine ELISA, both extraction protocols yielded identical results with a dog food sample adulterated with melamine. The recovery of melamine spiked into gravy from dog food using UD was 74%±4%. In conclusion, the recently released Abraxis ELISA for melamine proved to be a useful alternative to more cumbersome methods.
KW - adulteration
KW - contamination
KW - detection
KW - dog foods
KW - ELISA
KW - immunological techniques
KW - melamine
KW - enzyme linked immunosorbent assay
KW - serological techniques
KW - Feed Contamination, Residues and Toxicology (RR200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083098923&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: eric.garber@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modification of the submerged coil to prevent microbial carryover error in thermal death studies.
AU - Keller, S. E.
AU - Shazer, A. G.
AU - Fleischman, G. J.
AU - Chirtel, S.
AU - Anderson, N.
AU - Larkin, J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 4
SP - 775
EP - 780
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Keller, S. E.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20083125485. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - A submerged coil unit generates death rate data for foodborne pathogens through precise computer-controlled sequential sampling rather than the usual manually timed, labor-intensive single sampling associated with other approaches. Our work with Yersinia pseudotuberculosis and Listeria monocytogenes Scott A using the submerged coil unit indicated non-log-linear death rates with large degrees of tailing. Varying degrees of cell adhesion to the surface of the exit port resulted in carryover that was likely the primary cause of these non-log-linear kinetics. This carryover also resulted in erroneously high measured levels of thermal resistance for both organisms. To address the carryover problem, modifications were made to the exit port of the submerged coil unit to ensure continuous and uniform heat treatment. These modifications resulted in a 2-fold decrease in measured D-values for L. monocytogenes Scott A and a 10-fold decrease in measured D-values for Y. pseudotuberculosis. D-values measured with the modified machine for L. monocytogenes Scott A were similar to those found in the literature. Slight tailing in survival curves persisted with the modified method, particularly for Y. pseudotuberculosis. These results indicate that kinetic data for microbial death rates obtained using an unmodified submerged coil unit must be viewed with suspicion in light of the significant potential for carryover.
KW - heat resistance
KW - heat treatment
KW - mortality
KW - techniques
KW - Listeria monocytogenes
KW - Yersinia pseudotuberculosis
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - bacterium
KW - death rate
KW - heat processing
KW - submerged coil unit
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083125485&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: susanne.keller@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Factors influencing the growth of Salmonella during sprouting of naturally contaminated alfalfa seeds.
AU - Fu, T. J.
AU - Reineke, K. F.
AU - Chirtel, S.
AU - VanPelt, O. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 5
SP - 888
EP - 896
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Fu, T. J.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20083146877. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Postharvest Research; Human Nutrition; Horticultural Science
N2 - In this study, the factors that affect Salmonella growth during sprouting of naturally contaminated alfalfa seeds associated with two previous outbreaks of salmonellosis were examined. A minidrum sprouter equipped with automatic irrigation and rotation systems was built to allow sprouting to be conducted under conditions similar to those used commercially. The growth of Salmonella during sprouting in the minidrum was compared with that observed in sprouts grown in glass jars under conditions commonly used at home. The level of Salmonella increased by as much as 4 log units after 48 h of sprouting in jars but remained constant during the entire sprouting period in the minidrum. The effect of temperature and irrigation frequency on Salmonella growth was examined. Increasing the sprouting temperature from 20 to 30°C increased the Salmonella counts by as much as 2 log units on sprouts grown both in the minidrum and in the glass jars. Decreasing the irrigation frequency from every 20 min to every 2 h during sprouting in the minidrum or from every 4 h to every 24 h during sprouting in the glass jars resulted in an approximately 2-log increase in Salmonella counts. The levels of total aerobic mesophilic bacteria, coliforms, and Salmonella in spent irrigation water closely reflected those found in sprouts, confirming that monitoring of spent irrigation water is a good way to monitor pathogen levels during sprouting.
KW - food contamination
KW - lucerne
KW - microbial contamination
KW - seeds
KW - sprouting
KW - Medicago
KW - Medicago sativa
KW - Salmonella
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Medicago
KW - alfalfa
KW - bacterium
KW - food contaminants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083146877&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: tong.fu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of the U.S. Food and drug administration in the regulatory management of human listeriosis in the United States.
AU - Klontz, K. C.
AU - McCarthy, P. V.
AU - Datta, A. R.
AU - Lee, J. O.
AU - Acheson, D. W. K.
AU - Brackett, R. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 6
SP - 1277
EP - 1286
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Klontz, K. C.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
N1 - Accession Number: 20083179921. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Human Nutrition; Public Health; World Agriculture, Economics & Rural Sociology
N2 - From 1986 to 2006, the incidence of listeriosis in the United States dropped from approximately seven to three cases per million population, a reduction that most likely reflects the joint efforts of industry, government, consumers, and academia. Herein, we describe the U.S. Food and Drug Administration (FDA) strategy over the past three decades to combat listeriosis. Specifically, we discuss early actions taken to address outbreaks during the 1980s, policy decisions regarding the presence of Listeria monocytogenes in FDA-regulated foods, FDA compliance programs with L. monocytogenes components, enforcement actions to remove L. monocytogenes-contaminated products from the market (i.e., recalls) or to prevent entry of such products into the market (i.e., import detentions and refusals), research milestones, outreach and education efforts, and selected special projects. Evolving demographic trends in the United States may pose a challenge to further reduction of the incidence of listeriosis.
KW - bacterial diseases
KW - consumer protection
KW - education programmes
KW - food contamination
KW - food industry
KW - food policy
KW - food research
KW - food safety
KW - foodborne diseases
KW - foods
KW - government organizations
KW - human diseases
KW - import controls
KW - listeriosis
KW - market regulations
KW - microbial contamination
KW - outbreaks
KW - regulations
KW - USA
KW - Listeria monocytogenes
KW - man
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - consumer advocacy
KW - educational programs
KW - food contaminants
KW - listerellosis
KW - rules
KW - United States of America
KW - Research (AA500)
KW - Education and Training (CC100)
KW - Agencies and Organizations (DD100)
KW - Laws and Regulations (DD500)
KW - Food Economics (EE116) (New March 2000)
KW - Policy and Planning (EE120)
KW - International Trade (EE600)
KW - Marketing and Distribution (EE700)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083179921&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: karl.klontz@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies.
AU - Garber, E. A. E.
AU - Walker, J. L.
AU - O'Brien, T. W.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 9
SP - 1868
EP - 1874
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Garber, E. A. E.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD 20740, USA.
N1 - Accession Number: 20083281627. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Abrin is a toxic ribosome-inactivating protein present in beans of Abrus precatorius, also known as rosary peas. The possibility that abrin could be used to adulterate food has made the development of assays for the detection of abrin a priority. Rabbit-derived polyclonal antibodies and mouse monoclonal antibodies were prepared against a mixture of abrin isozymes. The specificity and cross-reactivity of the antibodies were evaluated against a challenge library of 40 grains, nuts, legumes, and foods. An enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescence (ECL)-based assay were assembled and optimized. Polyclonal (capture) and polyclonal (detection) ELISAs, polyclonal and monoclonal ELISAs, and polyclonal and monoclonal ECL assays had limits of detection (LODs) of 0.1 to 0.5 ng/ml for abrin in buffer. The LOD for abrin dissolved into juices, dairy products, soda, chocolate drink, and condiments and analyzed with the ECL assay ranged from 0.1 to 0.5 ng/ml in the analytical sample. In contrast, the LODs for the ELISAs ranged from 0.5 to 10 ng/ml in the analytical sample.
KW - adulterants
KW - antibodies
KW - beverages
KW - chemiluminescence immunoassays
KW - condiments
KW - cross reaction
KW - detection
KW - ELISA
KW - food contamination
KW - juices
KW - milk products
KW - proteins
KW - toxic substances
KW - Abrus precatorius
KW - Abrus
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - abrin
KW - dairy products
KW - drinks
KW - enzyme linked immunosorbent assay
KW - food contaminants
KW - poisons
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281627&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: eric.garber@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicity and detection of ricin and abrin in beverages.
AU - Garber, E. A. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 9
SP - 1875
EP - 1883
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Garber, E. A. E.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD 20740, USA.
N1 - Accession Number: 20083281628. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 9009-86-3, 7732-18-5. Subject Subsets: Human Nutrition
N2 - The oral and intraperitoneal (i. p.) toxicities to female BALB/c mice of ricin and abrin in phosphate-buffered saline (PBS), spring water, apple juice, and half-and-half (only oral) were examined after brief (2 h) and prolonged (11 to 13 days) storage. The ricin and abrin samples prepared in PBS had oral toxicities consistent with those previous studies, indicating oral and i. p. 50% lethal doses of >1 mg/kg of body weight and between 2 and 20 µg/kg of body weight, respectively. The toxicities of ricin and abrin in PBS were greater than those in apple juice and water. The oral toxicity of ricin and abrin in half-and-half appeared comparable to or less than that observed for the toxins in water. Spiked samples stored for a maximum of 11 days (13 for the abrin samples) at 4°C induced similar numbers of fatalities as did samples stored for only 2 h. Enzyme-linked immunosorbent assays of the samples administered by i. p. injection indicated a decrease in detectable toxin at 0.5 µg/ml.
KW - animal models
KW - apple juice
KW - beverages
KW - detection
KW - food contamination
KW - laboratory animals
KW - ricin
KW - toxic substances
KW - toxicity
KW - toxins
KW - water
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - abrin
KW - drinks
KW - food contaminants
KW - poisons
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Animal Models of Human Nutrition (VV140)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281628&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: eric.garber@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Modeling the physiological state of the inoculum and CO2 atmosphere on the lag phase and growth rate of Listeria monocytogenes.
AU - Jesús, A. J. de
AU - Whiting, R. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 9
SP - 1915
EP - 1918
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jesús, A. J. de: U.S. Food and Drug Administration, Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083281634. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 124-38-9. Subject Subsets: Human Nutrition
N2 - In previous studies, the growth of L. monocytogenes has been modeled under different CO2 headspace concentrations; however, the inoculum cells were always in the stationary phase. In this study, the growth of L. monocytogenes under different CO2 concentrations as affected by the physiological state of the cells was investigated. Exponential-growth-phase, stationary-phase, dried, and starved cells were prepared and inoculated at 5°C into brain heart infusion broths that had been preequilibrated under atmospheres of 0, 20, 40, 60, or 80% CO2 (the balance was N2). Lag-phase duration times (LDTs) and exponential growth rates were determined by enumerating cells at appropriate time intervals and by fitting the data to a three-phase linear function that has a lag period before the initiation of exponential growth. Longer LDTs were observed as the CO2 concentration increased, with no growth observed at 80% CO2. For example, the LDTs for exponential-phase, stationary-phase, starved, and dried cells were 2.21, 8.27, 9.17, and 9.67 days, respectively, under the 40% CO2 atmosphere. In general, exponential-growth-phase cells had the shortest LDT followed by starved cells and stationary-phase cells. Dried cells had the longest LDT. Exponential growth rates decreased as the CO2 concentrations increased. Once exponential growth was attained, no retained differences among the various initial physiological states of the cells for any of the atmospheres were observed in the exponential growth rates. The exponential growth rates under 0, 20, 40, 60, and 80% CO2 averaged 0.39, 0.37, 0.23, 0.23, and 0.0 log CFU/day, respectively. Dimensionless factors were calculated that describe the inhibitory action of CO2 on the LDTs and exponential growth rates for the various physiological states.
KW - carbon dioxide
KW - food contamination
KW - growth
KW - growth rate
KW - microbial contamination
KW - Listeria monocytogenes
KW - Listeria
KW - Listeriaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281634&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: antonio.dejesus@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Thermal resistance of Francisella tularensis in infant formula and fruit juices.
AU - Day, J. B.
AU - Trujillo, S.
AU - Hao, Y. Y. D.
AU - Whiting, R. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 11
SP - 2208
EP - 2212
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Day, J. B.: Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083325770. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Dairy Science; Medical & Veterinary Entomology
N2 - Francisella tularensis is a gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, little information exists on the thermal stability of this organism in food matrices. In the present study, the thermal resistance of the live vaccine strain of F. tularensis in four food products (liquid infant formula, apple juice, mango juice, and orange juice) was investigated. D-values ranged from 12 s (57.5°C) to 580 s (50°C) in infant formula with a z-value of 4.37°C. D-values in apple juice ranged from 8 s (57.5°C) to 59 s (50°C) with a z-value of 9.17°C. The live vaccine strain did not survive at temperatures above 55°C in mango juice and orange juice (>6-log inactivation). D-values at 55 to 47.5°C were 15 to 59 s in mango juice and 16 to 105 s in orange juice with z-values of 9.28 and 12.30°C, respectively. These results indicate that current pasteurization parameters used for destroying common foodborne bacterial pathogens are adequate for eliminating F. tularensis in the four foods tested. This study is the first to determine thermal inactivation of F. tularensis in specific foods and will permit comparisons with the thermal inactivation data of other more traditional foodborne pathogens.
KW - food contamination
KW - fruit juices
KW - Gram negative bacteria
KW - heat resistance
KW - infant formulae
KW - microbial contamination
KW - pasteurization
KW - tularaemia
KW - Bacteria
KW - Francisella tularensis
KW - Bacteria
KW - prokaryotes
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - bacterium
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - pasteurizing
KW - tularemia
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083325770&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: james.day@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Rapid detection of Salmonella in foods using real-time PCR.
AU - Cheng, C. M.
AU - Lin, W.
AU - Khanh Thien Van
AU - Lieuchi Phan
AU - Tran, N. N.
AU - Farmer, D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008///
VL - 71
IS - 12
SP - 2436
EP - 2441
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cheng, C. M.: U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Irvine, CA 92612, USA.
N1 - Accession Number: 20093015831. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Human Nutrition
N2 - Conventional methods for detection of Salmonella serovars in foods are generally time-consuming and labor intensive. A real-time PCR method has been developed with custom designed primers and a TaqMan probe to detect the presence of a 262-bp fragment of the Salmonella-specific invA gene. The method has been tested with a total of 384 field-isolated Salmonella serovars and non-Salmonella stock strains, as well as 420 U.S. Food and Drug Administration food samples, comprising a variety of food matrices. The method was highly specific in detecting Salmonella in spiked chili powder and shrimp samples, with a sensitivity of 0.04 CFU/g. In addition, the method is faster, more accurate, and less costly than the traditional U.S. Food and Drug Administration's Bacteriological Analytical Manual cell-culturing and the AOAC International-approved VIDAS methods to detect Salmonella in foods.
KW - detection
KW - food contamination
KW - foods
KW - genes
KW - methodology
KW - microbial contamination
KW - molecular genetics techniques
KW - polymerase chain reaction
KW - serovars
KW - shrimps
KW - Salmonella
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - methods
KW - PCR
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Diagnostic, Therapeutic and Pharmacological Biotechnology (WW700) (New June 2002)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093015831&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: chorng-ming.cheng@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment.
AU - Stefaniak, A. B.
AU - Chipera, S. J.
AU - Day, G. A.
AU - Sabey, P.
AU - Dickerson, R. M.
AU - Sbarra, D. C.
AU - Duling, M. G.
AU - Lawrence, R. B.
AU - Stanton, M. L.
AU - Scripsick, R. C.
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2008///
VL - 71
IS - 22
SP - 1468
EP - 1481
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Stefaniak, A. B.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083293898. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 µg/m3 (beryl ore grinding) to 2.1 µg/m3 (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were <20% in low-energy input operation areas (ore crushing, hydroxide product drumming) and >80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens.
KW - aerosols
KW - alloys
KW - berylliosis
KW - beryllium
KW - ceramics
KW - disease prevalence
KW - exposure
KW - immunopathology
KW - milling
KW - occupational hazards
KW - physicochemical properties
KW - respiratory diseases
KW - risk assessment
KW - risk factors
KW - work places
KW - berntrandite
KW - immunopathogenesis
KW - lung diseases
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083293898&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: AStefaniak@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Application of oligonucleotide microarray technology to toxic occupational exposures.
AU - Gwinn, M. R.
AU - Weston, A.
T2 - Journal of Toxicology and Environmental Health. Part A
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2008///
VL - 71
IS - 5/6
SP - 315
EP - 324
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Gwinn, M. R.: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083060302. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 50-32-8, 2439-01-2, 84-74-2, 121-75-5. Subject Subsets: Medical & Veterinary Entomology; Agricultural Entomology; Public Health; Plant Growth Regulators
N2 - Microarray technology has advanced toward analysis of toxic occupational exposures in biological systems. Microarray analysis is an ideal way to search for biomarkers of exposure, even if no specific gene or pathway has been identified. Analysis may now be performed on thousands of genes simultaneously, as opposed to small numbers of genes as in the past. This ability has been put to use to analyze gene expression profiles of a variety of occupational toxins in animal models to classify toxins into specific categories based on response. Analysis of normal human cell strains allows an extension of this analysis to investigate the role of interindividual variation in response to various toxins. This methodology was used to analyze four occupationally related toxins in our lab: oxythioquinox (OTQ), a quinoxaline pesticide; malathion, an organophosphate pesticide; di-n-butyl phthalate (DBP), a chemical commonly found in personal care and cosmetic items; and benzo[a]pyrene (BaP), an environmental and occupational carcinogen. The results for each exposure highlighted signaling pathways involved in response to these occupational exposures. Both pesticides showed increase in metabolic enzymes, while DBP showed alterations in genes related to fertility. BaP exposure showed alterations in two cytochrome P450s related to carcinogenicity. When used with occupational exposure information, these data may be used to augment risk assessment to make the workplace safer for a greater proportion of the workforce, including individuals susceptible to disease related to exposures.
KW - benzopyrene
KW - chinomethionat
KW - dibutyl phthalate
KW - DNA microarrays
KW - epithelium
KW - exposure
KW - malathion
KW - occupational hazards
KW - pesticides
KW - risk assessment
KW - toxic substances
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - oxythioquinox
KW - poisons
KW - quinomethionate
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083060302&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: agw8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A new chromogenic agar medium for detection of potentially virulent Yersinia enterocolitica.
AU - Weagant, S. D.
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2008///
VL - 72
IS - 2
SP - 185
EP - 190
CY - Oxford; UK
PB - Elsevier
SN - 0167-7012
AD - Weagant, S. D.: Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr. S. E., Bothell, WA 98021-4421, USA.
N1 - Accession Number: 20083074356. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Registry Number: 528-50-7. Subject Subsets: Soyabeans; Human Nutrition; Public Health
N2 - Several outbreaks of foodborne yersiniosis have been documented and this disease continues to be source of infections transmitted through foods. The selective agars most commonly used to isolate Yersinia enterocolitica in clinical, food and environmental samples, cefsulodin-irgasan-novobiocin (CIN) and MacConkey (MAC) agars, lack the ability to differentiate potentially virulent Y. enterocolitica from other Yersinia that may be present as well as some other bacterial spp. This study proposes the use of an agar medium, Y. enterocolitica chromogenic medium (YeCM), for isolation of potentially virulent Y. enterocolitica. This agar contains cellobiose as the fermentable sugar, a chromogenic substrate and selective inhibitors for suppression of colony formation by many competing bacteria. All strains of potentially virulent Yersinia of biotypes 1B, and biotypes 2-5 formed convex, red bulls-eye colonies on YeCM that were very similar to those described for CIN agar. However, Y. enterocolitica biotype 1A and other related Yersinia formed colonies that were purple/blue on YeCM while they formed typical red bulls-eye colonies on CIN agar. When a mixture of potentially virulent Y. enterocolitica biotype 1B, Y. enterocolitica biotype 1A and 5 other bacterial species was used to artificially contaminate tofu and then spread-plated on three selective agars, Y. enterocolitica biotype 1B colonies were easily distinguished from other strains on YeCM. However, Y. enterocolitica biotype 1B colonies were indistinguishable from many other colonies on CIN and only distinguishable from those of C. freundii on MAC. When colonies were picked and identified from these agars, typical colonies from YeCM were confirmed only as Y. enterocolitica biotype 1B. Typical colonies on CIN and MAC were found to belong to several competing species and biotypes.
KW - bacteriology
KW - biotypes
KW - cellobiose
KW - culture media
KW - foodborne diseases
KW - human diseases
KW - strain differences
KW - man
KW - Yersinia enterocolitica
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083074356&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T30-4R8NB61-1&_user=6686535&_coverDate=02%2F29%2F2008&_rdoc=11&_fmt=full&_orig=browse&_srch=doc-info(%23toc%234932%232008%23999279997%23678512%23FLA%23display%23Volume)&_cdi=4932&_sort=d&_docanchor=&_ct=17&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=7d86238f996925699f1aa63d79cf94d4
UR - email: steve.weagant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stability of picrotoxin during yogurt manufacture and storage.
AU - Jablonski, J. E.
AU - Jackson, L. S.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2008///
VL - 73
IS - 8
SP - T121
EP - T128
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0022-1147
AD - Jablonski, J. E.: U.S. Food and Drug Administration (FDA), Natl. Center for Food Safety & Technology (NCFST), 6502 S. Archer Rd., Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20083298859. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science
N2 - Picrotoxin is a neurotoxin found in the berries of Anamirta cocculus, a plant native to Southeast Asia. Picrotoxin has potential for being used as a biological weapon since the toxin is relatively easy to isolate and purify. Limited information exists on the stability and detection of picrotoxin added to foods before or after processing. The objective of this study was to determine the stability of picrotoxin during yogurt manufacture and storage. Direct, cup-set yogurt was produced by using methods that mimic the conditions used in full-scale production of yogurt. Milk (full-fat or low-fat) was pasteurized at 85°C for 30 min, and then cooled to 43°C. Yogurt starter culture (thermophilic culture or thermophilic+probiotic culture) and picrotoxin (200 µg/mL milk) were added. Samples of yogurt during fermentation (5 to 6 h, 43°C) and during 30 d refrigerated (4 to 6°C) storage were analyzed for pH, titratable acidity, and picrototoxin levels. Regardless of starter culture used or fat content of milk, there were no significant differences in the pH and titratable acidities of the picrotoxin-spiked yogurt and the control yogurt (no added picrotoxin) during fermentation and up to 4 wk of refrigerated storage. The color or texture of the yogurt was not affected by addition of picrotoxin. Levels of picrotoxinin and picrotin (components of picrotoxin) in yogurt, as measured by LC/MS (APCI+/SIR) did not change significantly during fermentation and storage. A separate experiment determined that addition of picrotoxin to milk before pasteurization (85°C, 30 min) did not affect picrotoxin stability. These results indicate that picrotoxin is stable in yogurt during manufacture and storage.
KW - fermentation
KW - food contamination
KW - food storage
KW - neurotoxins
KW - pasteurization
KW - pH
KW - refrigeration
KW - stability
KW - titratable acidity
KW - yoghurt
KW - Anamirta cocculus
KW - Anamirta
KW - Menispermaceae
KW - Ranunculales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - food contaminants
KW - hydrogen ion concentration
KW - joghurt
KW - pasteurizing
KW - potential of hydrogen
KW - yogurt
KW - Milk and Dairy Produce (QQ010)
KW - Food Processing (General) (QQ100)
KW - Food Storage and Preservation (QQ110)
KW - Microbial Technology in Food Processing (QQ120)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Chemistry (QQ600) (New June 2002)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083298859&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/JFDS
UR - email: joseph.jablonski@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Microbiological quality of bagged cut spinach and lettuce mixes.
AU - Valentin-Bon, I.
AU - Jacobson, A.
AU - Monday, S. R.
AU - Feng, P. C. H.
T2 - Applied and Environmental Microbiology
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2008///
VL - 74
IS - 4
SP - 1240
EP - 1242
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Valentin-Bon, I.: Division of Microbiology, United States Food and Drug Administration, HFS-711, FDA, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083057767. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - Analysis of 100 bagged lettuce and spinach samples purchased in 2007 from stores in District of Columbia, USA showed mean total bacterial counts of 7.0 log10 CFU/g and a broad range of <4 to 8.3 log10 CFU/g. Most probable numbers (MPN) of ≥11 000 coliforms/g were found in 55 samples, and generic Escherichia coli bacteria were detected in 16 samples, but no E. coli count exceeded 10 MPN/g.
KW - faecal coliforms
KW - food contamination
KW - lettuces
KW - microbial contamination
KW - spinach
KW - District of Columbia
KW - USA
KW - Escherichia coli
KW - Lactuca sativa
KW - Spinacia oleracea
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Lactuca
KW - Asteraceae
KW - Asterales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - E. coli
KW - fecal coliforms
KW - food contaminants
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083057767&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: peter.feng@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells.
AU - Woo SunWook
AU - Lee SungHee
AU - Ko GeoNil
AU - Kim YounChul
AU - Sohn DongHwan
JO - Planta Medica
JF - Planta Medica
Y1 - 2008///
VL - 74
IS - 8
SP - 834
EP - 839
CY - Stuttgart; Germany
PB - Georg Thieme Verlag
SN - 0032-0943
AD - Woo SunWook: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20083189707. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9026-43-1, 9059-22-7. Subject Subsets: Aromatic & Medicinal Plants; Agroforestry; Forestry
N2 - We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression. ISL significantly inhibited serum- or growth factor-induced HSC proliferation. The inhibition of platelet-derived growth factor (PDGF)-induced proliferation by ISL was associated with the mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-p70S6K pathways. ISL induced the expression of HO-1 in HSCs. Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1. These data suggest that HO-1 expression is responsible for the antiproliferative effect of ISL on HSCs.
KW - chalcones
KW - cytotoxicity
KW - enzymes
KW - heme oxygenase
KW - medicinal plants
KW - non-wood forest products
KW - pharmacology
KW - pigments
KW - protein kinase
KW - Dalbergia
KW - rats
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Dalbergia
KW - 1-phosphatidylinositol 3-kinase
KW - Dalbergia odorifera
KW - drug plants
KW - haem oxygenase
KW - heme oxygenase (decyclizing)
KW - medicinal herbs
KW - minor forest products
KW - non-timber forest products
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083189707&site=ehost-live&scope=site
UR - http://www.thieme-connect.com/ejournals/toc/plantamedica
UR - email: dhsohn@wonkwang.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Detection and quantification of group C rotaviruses in communal sewage.
AU - Meleg, E.
AU - Bányai, K.
AU - Martella, V.
AU - Jiang, B. M.
AU - Kocsis, B.
AU - Kisfali, P.
AU - Melegh, B.
AU - Szucs, G.
T2 - Applied and Environmental Microbiology
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2008///
VL - 74
IS - 11
SP - 3394
EP - 3399
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Meleg, E.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20083163058. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Pig Science; Soils & Fertilizers
N2 - Group C rotaviruses have been recognized as a cause of acute gastroenteritis in humans, cattle, and swine, although the true epidemiologic and clinical importance of this virus in these hosts has not yet been fully established. A real-time PCR assay based on a broadly reactive primer pair was developed and used to quantitatively determine the viral load of group C rotaviruses in environmental samples. A total of 35 raw and 35 treated sewage samples collected at the same sampling time in four Hungarian sewage treatment plants during a survey in 2005 were tested for the presence of group C rotaviruses. The overall detection rates were 91% (32 of 35) for the influent and 57% (20 of 35) for the effluent samples. Molecular characterization of the amplified partial VP6 gene revealed the cocirculation of human and animal (i.e., bovine and porcine) strains that were easily distinguishable by melting curve analysis. Human strains yielded relatively high viral loads (mean, 1.2×107; median, 6.9×105 genome equivalents per liter influent sewage) and appeared to display seasonal activity over the study period, whereas animal strains appeared to circulate throughout the year at much lower average titers (bovine strains mean, 9.9×104; median, 3.0×104; porcine strains mean, 3.9×104; median, 3.1×104 genome equivalents per liter influent sewage). Our findings suggest that monitoring of communal sewage may provide a good surrogate for investigating the epidemiology and ecology of group C rotaviruses in humans and animals.
KW - genomes
KW - microbial ecology
KW - nucleotide sequences
KW - oligonucleotides
KW - polymerase chain reaction
KW - sewage
KW - sewage effluent
KW - sewage treatment
KW - Hungary
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - DNA sequences
KW - PCR
KW - sewage treatment plants
KW - Water Resources (PP200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Wastes and Refuse (XX300)
KW - Microbial Ecology (ZZ333) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083163058&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: szucsgy@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biological enrichment of mycoplasma agents by cocultivation with permissive cell cultures.
AU - Volokhov, D. V.
AU - Kong, H. S.
AU - George, J.
AU - Anderson, C.
AU - Chizhikov, V. E.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2008///
VL - 74
IS - 17
SP - 5383
EP - 5391
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Volokhov, D. V.: U.S. Food and Drug Administration, Center for Biologies Evaluation and Research, Office of Vaccine Research and Review, Division of Viral Products, Laboratory of Methods Development, HFM-470, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20083260255. Publication Type: Journal Article. Language: English. Number of References: 68 ref. Subject Subsets: Veterinary Science; Veterinary Science; Pig Science
N2 - In this study, we describe our results on the evaluation of the ability of different permissive mammalian cell lines to support the biological enrichment of mycoplasma species known to be bacterial contaminants of cell substrates. The study showed that this approach is able to significantly improve the efficiency of mycoplasma detection based on nucleic acid testing or biochemical technologies (e.g., MycoAlert mycoplasma detection). Of 10 different cell lines (Vero, MDBK, HEK-293, Hep-G2, CV-1, EBTr, WI-38, R9ab, MDCK, and High Five) used in the study, only MDCK cell culture was found to support the efficient growth of all the tested mycoplasmas (Mycoplasma arginini, M. bovis, M. fermentans, M. gallinaceum, M. gattisepticum, M. synoviae, M. hominis, M. hyorhinis, M. orale, M. salivarium, and Acholeplasma laidlawii) known to be most frequently associated with contamination of cell substrates and cell lines in research laboratories or manufacturing facilities. The infection of MDCK cells with serial dilutions of each mycoplasma species demonstrated that these common cell line contaminants can be detected reliably after 7-day enrichment in MDCK cell culture at contamination levels of 0.05 to 0.25 CFU/ml. The High Five insect cell line was also found to be able to support the efficient growth of most mycoplasma species tested, except for M. hyorhinis strain DBS1050. However, mycoplasma growth in insect cell culture was demonstrated to be temperature dependent, and the most efficient growth was observed when the incubation temperature was increased from 28°C to between 35 and 37°C. We believe that this type of mycoplasma enrichment is one of the most promising approaches for improving the purity and safety testing of cell substrates and other cell-derived biologies and pharmaceuticals.
KW - cell cultures
KW - cell lines
KW - culture media
KW - growth
KW - Mycoplasma
KW - Mycoplasma hyorhinis
KW - Mycoplasmataceae
KW - Mycoplasmatales
KW - Mollicutes
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Mycoplasma
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083260255&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: dmitriy.volokhov@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant.
AU - Jung, C. M.
AU - Heinze, T. M.
AU - Deck, J.
AU - Strakosha, R.
AU - Sutherland, J. B.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2008///
VL - 74
IS - 19
SP - 6147
EP - 6150
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Jung, C. M.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083272968. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Soils & Fertilizers
N2 - Samples from a waste water treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter-1) disappeared in 12 days, with the appearance of a transient metabolite and two nitrosated compounds.
KW - fluoroquinolones
KW - metabolites
KW - piperazines
KW - sewage
KW - sewage treatment
KW - wastewater
KW - wastewater treatment
KW - wastewater treatment plants
KW - waste water
KW - waste water treatment
KW - waste water treatment plants
KW - waste-water treatment
KW - waste-water treatment plants
KW - Water Resources (PP200)
KW - Human Wastes and Refuse (XX300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083272968&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: john.sutherland@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antimicrobial resistance in Salmonella enterica serovar Heidelberg isolates from retail meats, including poultry, from 2002 to 2006.
AU - Zhao, S.
AU - White, D. G.
AU - Friedman, S. L.
AU - Glenn, A.
AU - Blickenstaff, K.
AU - Ayers, S. L.
AU - Abbott, J. W.
AU - Hall-Robinson, E.
AU - McDermott, P. F.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2008///
VL - 74
IS - 21
SP - 6656
EP - 6662
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083302487. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 80370-57-6, 85721-33-1, 58001-44-8, 1403-66-3, 1405-41-0, 8063-07-8, 57-92-1, 723-46-6. Subject Subsets: Poultry; Human Nutrition; Pig Science
N2 - Salmonella enterica serovar Heidelberg frequently causes food-borne illness in humans. There are few data on the prevalence, antimicrobial susceptibility, and genetic diversity of Salmonella serovar Heidelberg isolates in retail meats. We compared the prevalences of Salmonella serovar Heidelberg in a sampling of 20,295 meats, including chicken breast (n=5,075), ground turkey (n=5,044), ground beef (n=5,100), and pork chops (n=5,076), collected during 2002 to 2006. Isolates were analyzed for antimicrobial susceptibility and compared genetically using pulsed-field gel electrophoresis (PFGE) and PCR for the blaCMY gene. A total of 298 Salmonella serovar Heidelberg isolates were recovered, representing 21.6% of all Salmonella serovars from retail meats. One hundred seventy-eight (59.7%) were from ground turkey, 110 (36.9%) were from chicken breast, and 10 (3.4%) were from pork chops; none was found in ground beef. One hundred ninety-eight isolates (66.4%) were resistant to at least one compound, and 49 (16.4%) were resistant to at least five compounds. Six isolates (2.0%), all from ground turkey, were resistant to at least nine antimicrobials. The highest resistance in poultry isolates was to tetracycline (39.9%), followed by streptomycin (37.8%), sulfamethoxazole (27.7%), gentamicin (25.7%), kanamycin (21.5%), ampicillin (19.8%), amoxicillin-clavulanic acid (10.4%), and ceftiofur (9.0%). All isolates were susceptible to ceftriaxone and ciprofloxacin. All ceftiofur-resistant strains carried blaCMY. PFGE using XbaI and BlnI showed that certain clones were widely dispersed in different types of meats and meat brands from different store chains in all five sampling years. These data indicate that Salmonella serovar Heidelberg is a common serovar in retail poultry meats and includes widespread clones of multidrug-resistant strains.
KW - amoxicillin
KW - ampicillin
KW - ceftiofur
KW - chicken meat
KW - ciprofloxacin
KW - clavulanic acid
KW - drug susceptibility
KW - food contamination
KW - foodborne diseases
KW - genes
KW - genetic diversity
KW - genotypes
KW - gentamicin
KW - kanamycin
KW - multiple drug resistance
KW - poultry
KW - pulsed field electrophoresis
KW - streptomycin
KW - sulfamethoxazole
KW - turkey meat
KW - fowls
KW - Salmonella enterica
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - amoxycillin
KW - bacterium
KW - chickens
KW - co-amoxiclav
KW - domesticated birds
KW - food contaminants
KW - sulphamethoxazole
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083302487&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: patrick.mcdermott@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Responder safety and health: preparing for future disasters.
AU - Reissman, D. B.
AU - Howard, J.
A2 - Asbell, P.
T3 - Special Issue: 9/11 World Trade Center disaster, past and future.
JO - Mount Sinai Journal of Medicine
JF - Mount Sinai Journal of Medicine
Y1 - 2008///
VL - 75
IS - 2
SP - 135
EP - 141
CY - Chichester; UK
PB - John Wiley & Sons
SN - 0027-2507
AD - Reissman, D. B.: Office of the Director, National Institute for Occupational Safety and Health, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20083216131. Publication Type: Journal Article. Note: Special Issue: 9/11 World Trade Center disaster, past and future. Language: English. Number of References: 29 ref. Subject Subsets: Public Health
N2 - This article reviews lessons learned about managing the safety and health of workers who were involved in disaster response, recovery, and cleanup after the 2001 World Trade Center (WTC) disaster. The first two sections review ongoing responder health burdens and the tragic toll of this disaster from a worker safety and health perspective. The remaining sections address changes in federal infrastructure, response planning, and resources for protection of response and recovery personnel. Proper preparation includes pre-event and "just-in-time" disaster-worker training on likely hazards, organizational assets for hazard monitoring, and hands-on instruction in the use of assigned protective equipment. Good planning includes predeployment medical review to ensure "fitness for duty" and considers the following: (1) personal risk factors, (2) hazards likely to be associated with particular field locations, and (3) risks involved with assigned tasks (eg, workload and pace, work/rest cycles, available resources, and team/supervisory dynamics). Planning also should address worker health surveillance, medical monitoring, and availability of medical care (including mental health services). Disaster safety managers should anticipate likely hazards within planning scenarios and prepare asset inventories to facilitate making timely safety decisions. Disaster safety management begins immediately and provides ongoing real-time guidance to incident leadership at all levels of government. Robust standards must be met to reliably protect workers/responders. An integrated and measurable multiagency safety management function must be built into the incident command system before an incident occurs. This function delineates roles and responsibilities for rapid exposure assessments, ensuring cross-agency consistency in data interpretation, and timely, effective communication of information and control strategies. The ability to perform this safety management function should be tested and evaluated in exercise simulations and drills at multiple levels. Joint planning and exercising of the safety management plan and its function are effective ways to build interagency relationships and to be more systemic in managing logistics for safety equipment and converging personnel. Planning must include mechanisms to enable safety decisions to be implemented - such as effective and rapid scene control (site access), personnel tracking, and safety enforcement. Worker safety and health preparedness and leadership are essential for protecting workers and promoting resiliency among personnel involved in disaster response, recovery, and cleanup.
KW - disasters
KW - emergencies
KW - health hazards
KW - health protection
KW - health services
KW - occupational hazards
KW - planning
KW - reviews
KW - safety
KW - safety at work
KW - terrorism
KW - training
KW - workers
KW - New York
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Policy and Planning (EE120)
KW - Health Services (UU350)
KW - Conflict (UU495) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083216131&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/112736813/home
UR - email: DReissman@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of mold and dampness-associated respiratory morbidity in 2 schools: comparison of questionnaire survey responses to national data.
AU - Sahakian, N. M.
AU - White, S. K.
AU - Park, J. H.
AU - Cox-Ganser, J. M.
AU - Kreiss, K.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2008///
VL - 78
IS - 1
SP - 32
EP - 37
CY - Boston; USA
PB - Blackwell Publishing
SN - 0022-4391
AD - Sahakian, N. M.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083087313. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Background: Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students. Methods: School employees (n=309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Results: Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections. Conclusions: This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited.
KW - air quality
KW - asthma
KW - fatigue
KW - headaches
KW - human diseases
KW - moisture
KW - morbidity
KW - moulds
KW - occupational hazards
KW - occupational health
KW - personnel
KW - public schools
KW - respiratory diseases
KW - skin diseases
KW - students
KW - surveys
KW - USA
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - dermatoses
KW - employees
KW - lung diseases
KW - molds
KW - staff
KW - tiredness
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083087313&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1746-1561.2007.00263.x
UR - email: nsahakian@cdc.gov\swhite4@cdc.gov\jpark2@cdc.gov\jcoxganser@cdc.gov\kkreiss@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA perspective on antivirals against biothreats: communicate early and often.
AU - Roberts, R.
AU - Styrt, B.
AU - McCune, S.
A2 - Bray, M.
A2 - Neyts, J.
T3 - Special Issue: Treatment of highly pathogenic RNA viral infections.
JO - Antiviral Research
JF - Antiviral Research
Y1 - 2008///
VL - 78
IS - 1
SP - 60
EP - 63
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-3542
AD - Roberts, R.: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Counter-Terrorism and Emergency Coordination, 10903 New Hampshire Avenue, White Oak Campus, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20083126128. Publication Type: Journal Article. Note: Special Issue: Treatment of highly pathogenic RNA viral infections. Language: English. Number of References: 1 ref. Subject Subsets: Public Health
N2 - Development of antiviral products for certain highly pathogenic viruses with limited available treatments, such as viruses that may have biothreat potential, is critically important and challenging. The mission of the FDA is to protect the public health by assuring the safety, efficacy and quality of such products. Human clinical trials are critically important whenever relevant naturally occurring diseases can appropriately be studied. In selected situations when clinical studies are not ethical and field efficacy studies are not feasible, the Animal Rule (67 FR 37988, 2002) introduces the possibility of drug/biologic approval/licensure based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. This approach necessitates the development of well-delineated animal models predictive of human disease and treatment responses, and plans for adding human information if suitable circumstances arise. Efficient development of therapeutics against these agents requires collaborative efforts among industry, academia and federal agencies.
KW - antiviral agents
KW - biological warfare
KW - drug therapy
KW - human diseases
KW - pathogens
KW - terrorism
KW - viral diseases
KW - man
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083126128&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01663542
UR - email: rosemary.roberts@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative neuropathogenesis and neurovirulence of attenuated flaviviruses in nonhuman primates.
AU - Maximova, O. A.
AU - Ward, J. M.
AU - Asher, D. M.
AU - St. Claire, M.
AU - Finneyfrock, B. W.
AU - Speicher, J. M.
AU - Murphy, B. R.
AU - Pletnev, A. G.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008///
VL - 82
IS - 11
SP - 5255
EP - 5268
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Maximova, O. A.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20093228323. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Medical & Veterinary Entomology; Veterinary Science; Public Health; Veterinary Science
N2 - Based on previous preclinical evaluation in mice and monkeys, the chimeric TBEV/DEN4Δ30 virus, carrying the prM and E protein genes from a highly virulent Far Eastern strain of tick-borne encephalitis virus (TBEV) on the backbone of a nonneuroinvasive dengue type 4 virus (DEN4), has been identified as a promising live attenuated virus vaccine candidate against disease caused by TBEV. However, prior to use of this vaccine candidate in humans, its neurovirulence in nonhuman primates needed to be evaluated. In the present study, we compared the neuropathogenesis of the chimeric TBEV/DEN4Δ30 virus; Langat virus (LGTV), a former live TBEV vaccine; and yellow fever 17D virus vaccine (YF 17D) in rhesus monkeys inoculated intracerebrally. TBEV/DEN4Δ30 and YF 17D demonstrated remarkably similar spatiotemporal profiles of virus replication and virus-associated histopathology in the central nervous system (CNS) that were high in cerebral hemispheres but progressively decreased toward the spinal cord. In contrast, the neurovirulence of LGTV exhibited the reverse profile, progressing from the site of inoculation toward the cerebellum and spinal cord. Analysis of the spatiotemporal distribution of viral antigens in the CNS of monkeys revealed a prominent neurotropism associated with all three attenuated viruses. Nevertheless, TBEV/DEN4Δ30 virus exhibited higher neurovirulence in monkeys than either LGTV or YF 17D, suggesting insufficient attenuation. These results provide insight into the neuropathogenesis associated with attenuated flaviviruses that may guide the design of safe vaccines.
KW - central nervous system
KW - cerebellum
KW - chimaeras
KW - histopathology
KW - live vaccines
KW - nervous system diseases
KW - neurophysiology
KW - pathogenesis
KW - spinal cord
KW - viral replication
KW - virulence
KW - zoonoses
KW - Dengue 4 virus
KW - Flavivirus
KW - Langat virus
KW - Macaca mulatta
KW - man
KW - monkeys
KW - Primates
KW - Tick-borne encephalitis virus
KW - Dengue virus
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - attenuated vaccines
KW - brain cerebellum
KW - chimeras
KW - CNS
KW - neuropathy
KW - Tickborne encephalitis virus
KW - zoonotic infections
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Veterinary Pests, Vectors and Intermediate Hosts (LL823) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093228323&site=ehost-live&scope=site
UR - http://jvi.asm.org/
UR - email: apletnev@niaid.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification of residues outside of the receptor binding domain that influence the infectivity and tropism of porcine endogenous retrovirus.
AU - Argaw, T.
AU - Figueroa, M.
AU - Salomon, D. R.
AU - Wilson, C. A.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008///
VL - 82
IS - 15
SP - 7483
EP - 7491
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0022-538X
AD - Argaw, T.: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Building 29B, Room 5NN22, HFM 725, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093245920. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Veterinary Science; Veterinary Science; Public Health; Pig Science
N2 - Identification of determinants of human tropism of porcine endogenous retrovirus (PERV) is critical to understanding the risk of transmission of PERV to recipients of porcine xenotransplantation products. Previously, we showed that a chimeric envelope cDNA encoding the 360 N-terminal residues of the human-tropic PERV envelope class A (PERV-A) SU and the 130 C-terminal residues of the pig-tropic PERV-C SU and all of TM (PERV-A/C) showed a 100-fold decrease in infectivity titer on human cells (M. Gemeniano, O. Mpanju, D. R. Salomon, M. V. Eiden, and C. A. Wilson, Virology 346:108-117, 2006). To identify residues important for human cell infection, we performed site-directed mutagenesis on each of the nine residues, singly or in combination, that distinguish the C-terminal region of PERV-C from PERV-A. Of the nine amino acids, two single-amino-acid substitutions, Q374R and I412V, restored the infectivity of human cells to the chimeric PERV-A/C to a titer equivalent to that of PERV-A. In contrast, PERV-A/C mutant envelope Q439P resulted in undetectable infection of human cells and an approximately 1,000-fold decrease in control pig cells. Mutation of K441R rescued mutants that carried Q439P, suggesting an incompatibility between the proline residue at this position and the presence of KK in the proteolytic cleavage signal. We confirmed this incompatibility with vectors carrying PERV-A envelope mutant R462K that were also rendered noninfectious. Finally, tropism of vectors carrying PERV-C envelope mutants with only four amino acid changes in the C terminus of PERV-C envelope, NHRQ436YNRP plus K441R, was shifted to one similar to that of PERV-A. Our results show an important and previously unrecognized role for infectivity and tropism for residues at the C terminus of SU.
KW - chimaeras
KW - complementary DNA
KW - disease transmission
KW - human diseases
KW - infectivity
KW - mutagenesis
KW - xenotransplantation
KW - zoonoses
KW - man
KW - pigs
KW - Retroviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Retroviridae
KW - cDNA
KW - chimeras
KW - hogs
KW - porcine endogenous retrovirus
KW - swine
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093245920&site=ehost-live&scope=site
UR - http://jvi.asm.org/
UR - email: carolyn.wilson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of psychological stress due to assigned task on sleep architecture under the condition of repeated sleep restriction and subsequent recovery.
AU - Kubo, T.
AU - Sasaki, T.
AU - Matsumoto, S.
JO - Journal of Science of Labour
JF - Journal of Science of Labour
Y1 - 2008///
VL - 84
IS - 4
SP - 119
EP - 128
CY - Kawasaki; Japan
PB - Institute for Science of Labour
SN - 0022-443X
AD - Kubo, T.: Health Administration and Psychosocial Factor Research Group, National Institute of Occupational Safety and Health, Kiyose, Tokyo, Japan.
N1 - Accession Number: 20083313972. Publication Type: Journal Article. Language: Japanese. Language of Summary: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - The purpose of this study was to examine the impact of psychological stress on sleep architecture under the condition of sleep restriction with assigned tasks and subsequent restoration periods. Male participants (N=16; mean age; 27.3, range; 19-38 years) were required to attend a laboratory for sixteen consecutive nights for the recording of their performance under the following conditions: adaptation night (A; 23:00- 7:00), baseline night (B; 23:00- 7:00), sleep restriction night 1- 10 (SR1-SR10; 01: 00- 6: 00) and recovery night 1- 4 (R1- R4; 23: 00- 7: 00). The data of four participants were, however, excluded from the analysis because of technical failures. To expose the participants to psychological stress due to the assigned tasks, they were required to complete English transcription tasks by SR10. The participants were informed that they would not receive compensation (255 000 yen) if they could not complete the assigned tasks in time. Therefore, the psychological stress in this study was mainly due to the factors of assigned tasks. However, they received the compensation regardless of their achievement at the end of the experiment. Sleep architecture was evaluated by sleep efficiency, %S2, %SWS, %REM sleep and REM sleep latency. To reveal the impact of the psychological stress on sleep architecture, all participants were classified into completed group (N=60) and the non-completed group (N=60), according to the achievement of the tasks. Most of characteristic findings in this study were the variables of REM sleep. Results revealed a shorter REM sleep latency and a greater REM sleep (in minutes), %REM sleep in the non-completed group compared with the completed group (REM sleep latency : F1,10=5.957, P=0.035, REM sleep; F1,10=7.736, P=0.019, %REM sleep; F1,10=13.054, P=0.005, respectively). It should be noted that participants in the non-completed group had difficulty in recovering from the impact of psychological stress, and had not recovered by the fourth night of recovery sleep. In summary, the results suggested that psychological stress in this study had an impact on the expression of REM sleep.
KW - mental stress
KW - psychology
KW - sleep
KW - Japan
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - psychological factors
KW - psychological stress
KW - Human Physiology and Biochemistry (VV050)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083313972&site=ehost-live&scope=site
UR - http://www.isl.or.jp
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Vitamin D and health in the 21st century: an update. Proceedings of a conference and roundtable discussion held in Bethesda, MD, USA, 5-7 September 2007.
AU - Brannon, P. M.
AU - Yetley, E. A.
AU - Picciano, M. F.
A2 - Brannon, P. M.
A2 - Yetley, E. A.
A2 - Picciano, M. F.
T2 - American Journal of Clinical Nutrition
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2008///
VL - 88
IS - 2(S)
SP - 483S
EP - 592S
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Brannon, P. M.: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, 6100 Executive Boulevard, Room 3B01, MSC 7517, Bethesda, MD 20892-7517, USA.
N1 - Accession Number: 20083251745. Publication Type: Journal issue; Conference proceedings. Language: English. Registry Number: 7440-70-2, 7439-95-4, 1406-16-2. Subject Subsets: Human Nutrition; Public Health
N2 - We summarize the key findings, strength of the evidence, and research needs identified in the National Institutes of Health conference "Vitamin D and Health in the 21st Century: an Update," which was held in September 2007; a systematic evidence-based review; and a National Institutes of Health roundtable discussion held after the conference by scientists with relevant expertise. The evidence-based review addressed 5 questions on 25-hydroxyvitamin D [25(OH)D] and functional outcomes across the life cycle and response to exposure, bone health outcomes of supplementation, risks and benefits of sun exposure, and adverse outcomes. These questions also framed the conference and roundtable discussions. Researchers have made considerable progress in understanding the relation of 25(OH)D to bone health outcomes in the elderly and in postmenopausal women, but we know less about its impact on other stages of the life cycle and in racial and ethnic groups. Limitations of the existing data include the failure of many studies to control for important confounders [baseline 25(OH)D concentration, skin pigmentation, body mass index, compliance, etc], sparse data on key vulnerable populations (dark-skinned persons, reproducing women, infants, children, and adolescents), problems of accuracy and excessive variability in measuring 25(OH)D, lack of established relation of 25(OH)D with functional outcomes except in the elderly, and limited information on the effects of vitamin D independent of calcium, magnesium, and phosphate. Future research should determine and validate across the life cycle relevant functional outcomes for bone and other health factors as well as adverse outcomes for the biomarker of exposure, 25(OH)D, to enable assessment of the role of vitamin D status in health maintenance and disease prevention.
KW - adolescents
KW - body mass index
KW - body measurements
KW - body weight
KW - calcium
KW - children
KW - disease prevention
KW - effects
KW - elderly
KW - ethnic groups
KW - health
KW - height
KW - infants
KW - life cycle
KW - magnesium
KW - menopause
KW - pigmentation
KW - prevention
KW - research
KW - vitamin D
KW - vitamins
KW - weight
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - elderly people
KW - older adults
KW - senior citizens
KW - studies
KW - teenagers
KW - United States of America
KW - Human Nutrition (General) (VV100)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Human Physiology and Biochemistry (VV050)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083251745&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: piccianm@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Summary of roundtable discussion on vitamin D research needs.
AU - Brannon, P. M.
AU - Yetley, E. A.
AU - Bailey, R. L.
AU - Picciano, M. F.
A2 - Brannon, P. M.
A2 - Yetley, E. A.
A2 - Picciano, M. F.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2008///
VL - 88
IS - 2(S)
SP - 587S
EP - 592S
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Brannon, P. M.: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, 6100 Executive Boulevard, MSC 7517, Bethesda, MD 20892-7517, USA.
N1 - Accession Number: 20083251764. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 5 ref. Registry Number: 7440-70-2, 1406-16-2. Subject Subsets: Dairy Science; Human Nutrition; Public Health
N2 - We summarize the discussions of a roundtable following the conference "Vitamin D and Health in the 21st Century: an Update." The roundtable participants offered additional information on vitamin D research needs from a critical, impartial, and interdisciplinary perspective. Although the group recognized the progress to date, they found that the available evidence on the relation of 25-hydroxyvitamin D, dietary intake, status, functional health, and adverse outcomes has significant limitations because most studies have been short term, have failed to consider important confounders such as baseline vitamin D status and body mass index, and did not study key populations. To meet these data gaps, the roundtable identified several overarching research needs: (1) long-term, high-quality dose-response studies with relevant outcomes, including bone health, other functional outcomes (such as immune function, autoimmune disorders, and chronic disease prevention), and adverse outcomes (such as hypercalcaemia and hypercalcuria), especially in understudied population groups such as dark-skinned individuals, infants, adolescents, reproductive-aged women, and pregnant and lactating women; (2) further research to understand the relation of 25-hydroxyvitamin D threshold values to relevant functional outcomes in each life stage and in racial and ethnic groups; (3) further research to understand the metabolic partitioning, fate, and mobilization of key vitamin D metabolites at recommended and greater than recommended intakes to assess the availability of stored vitamin D, relative contributions of endogenously produced and dietary vitamin D, and impact of important confounders (such as body mass index) on vitamin D status; and (4) further research to define the maximal, long-term vitamin D intake to ensure safety for all humans.
KW - adolescents
KW - autoimmune diseases
KW - body mass index
KW - body measurements
KW - body weight
KW - calcium
KW - children
KW - diets
KW - disease prevention
KW - ethnic groups
KW - food intake
KW - health
KW - height
KW - hypercalcaemia
KW - immune response
KW - infants
KW - lactating women
KW - lactation
KW - metabolites
KW - pregnancy
KW - prevention
KW - research
KW - vitamin D
KW - vitamins
KW - weight
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - gestation
KW - hypercalcemia
KW - hypercalcinemia
KW - immunity reactions
KW - immunological reactions
KW - studies
KW - teenagers
KW - Human Nutrition (General) (VV100)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Diet Studies (VV110)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083251764&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: piccianm@od.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular characterization of medically important viruses of the genus Orthobunyavirus.
AU - Lambert, A. J.
AU - Lanciotti, R. S.
JO - Journal of General Virology
JF - Journal of General Virology
Y1 - 2008///
VL - 89
IS - 10
SP - 2580
EP - 2585
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-1317
AD - Lambert, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20083263631. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - We have characterized the full-length S segment RNA sequences of five human pathogens of the virus family Bunyaviridae, genus Orthobunyavirus. S segment sequences of Fort Sherman, Shokwe and Xingu viruses of the Bunyamwera serogroup, as well as those of Bwamba and Pongola viruses of the Bwamba serogroup, are described. S segment sequences of Bwamba and Pongola viruses represent the first nucleotide sequences characterized for viruses of the Bwamba serogroup. The described molecular and phylogenetic analyses of these and other selected viruses of the genus Orthobunyavirus reveal that a close sequence similarity is shared between the African Bwamba and the predominantly North American and European California serogroups of the genus Orthobunyavirus.
KW - human diseases
KW - nucleotide sequences
KW - phylogenetics
KW - phylogeny
KW - viral diseases
KW - Bunyamwera virus
KW - Bwamba virus
KW - man
KW - Orthobunyavirus
KW - Orthobunyavirus
KW - Bunyaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - DNA sequences
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083263631&site=ehost-live&scope=site
UR - http://vir.sgmjournals.org
UR - email: ahk7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Does participation in the Food Stamp Program increase the prevalence of obesity and health care spending?
AU - Meyerhoefer, C. D.
AU - Pylypchuk, Y.
JO - American Journal of Agricultural Economics
JF - American Journal of Agricultural Economics
Y1 - 2008///
VL - 90
IS - 2
SP - 287
EP - 305
CY - Boston; USA
PB - Blackwell Publishing
SN - 0002-9092
AD - Meyerhoefer, C. D.: U.S. Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083144085. Publication Type: Journal Article. Language: English. Number of References: 45 ref.
N2 - We use panel data techniques and information on state-level Food Stamp Program characteristics to obtain unbiased estimates of the impact of Food Stamp Program participation on weight status and health care spending among nonelderly adults. Our results suggest that program participation by women leads to a 5.9% (p=0.07) increase in their likelihood of overweight and obesity, which is smaller than previous estimates, and to higher medical expenditures. The direct effect of program participation on medical spending through higher discretionary income is significantly larger than the indirect effect through changes in weight status.
KW - adults
KW - disease prevalence
KW - expenditure
KW - food aid
KW - Food Stamp Program
KW - health care costs
KW - obesity
KW - overweight
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Food Economics (EE116) (New March 2000)
KW - Health Economics (EE118) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083144085&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/ajae
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Alkaloids and saponins in dietary supplements of blue cohosh (Caulophyllum thalictroides).
AU - Satchithanandam, S.
AU - Grundel, E.
AU - Roach, J.
AU - White, K. D.
AU - Mazzola, E.
AU - Ganzera, M.
AU - Rader, J. I.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 1
SP - 21
EP - 32
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Satchithanandam, S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD 20740, USA.
N1 - Accession Number: 20083062149. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Human Nutrition; Horticultural Science; Aromatic & Medicinal Plants
N2 - Preparations of blue cohosh (Caulophyllum thalictroides) have been used traditionally by Native Americans for medicinal purposes. Dietary supplements containing dried roots or extracts of blue cohosh rhizomes are available as dietary supplements. The safety and efficacy of these preparations have not been systematically evaluated. Recent studies indicate that ingestion of specific alkaloids in blue cohosh preparations can produce birth defects and neonatal heart failure. Blue cohosh also contains saponins, which may be responsible for uterine-stimulating effects. We determined the amounts of major alkaloids and saponins in preparations of blue cohosh by high-performance liquid chromatography (HPLC). Alkaloids and saponins were monitored with a photodiode array detector and an evaporative light-scattering detector, respectively. Profiles were compared with those of authenticated blue cohosh root extracts. Identities of the alkaloids and saponins were confirmed by HPLC/mass spectrometry and nuclear magnetic resonance spectrometry. Calculations based on the results of analyses of dietary supplements showed that maximum daily intake of alkaloids and saponins will vary with the form (e.g., root, liquid extract) and doses recommended in product labeling. Intakes may vary from <1 to 75 mg/day for alkaloids and from about 9 to 420 mg/day for saponins.
KW - alkaloids
KW - food composition
KW - food supplements
KW - medicinal plants
KW - saponins
KW - Berberidaceae
KW - Ranunculales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Berberidaceae
KW - Caulophyllum
KW - Caulophyllum thalictroides
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083062149&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: jeanne.rader@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The effect of preenrichment and selective enrichment media on recovery of Salmonella Typhi from the tropical fruit mamey.
AU - Hammack, T. S.
AU - Jacobson, A. P.
AU - Andrews, W. H.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 1
SP - 83
EP - 91
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Hammack, T. S.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Microbiology, College Park, MD 20740, USA.
N1 - Accession Number: 20083062153. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Human Nutrition; Postharvest Research
N2 - The Bacteriological Analytical Manual (BAM) Salmonella culture method did not detect Salmonella Typhi in mamey, the tropical fruit that was implicated in a 1999 typhoid outbreak. The relative effectiveness of BAM's nonselective preenrichment and selective media for the recovery of S. Typhi from mamey was examined to determine if the BAM's preenrichment/selective enrichment strategy was the cause of the method's failure with this food. The preenrichment media were lactose broth, buffered peptone water (BPW), and universal preenrichment (UP) broth. The selective enrichment media were selenite cystine (SC) broth, tetrathionate (TT) broth, and Rappaport-Vassiliadis (RV) medium. UP broth was significantly more effective (P<0.05) than either lactose broth or BPW for the recovery of 2 different S. Typhi strains from mamey. Of 120 test portions tested, 105 S. Typhi-positive test portions were recovered using UP broth, whereas only 1 S. Typhi-positive test portion was recovered using BPW, and no S. Typhi-positive test portions were recovered using lactose broth. SC and TT broths were both significantly more effective (P<0.05) than RV medium. Of 105 S. Typhi-positive test portions, SC broth recovered 80, TT broth recovered 67, and RV medium recovered 9. After the above comparison, an incomplete UP (UPI) broth formulation was found to be significantly more effective (P<0.05) than the complete formulation (UPC). Of 80 total positive test portions, UPI recovered 71, whereas UPC recovered only 48. The following UP broth formulations were compared to determine if any of the components of the UP broth formulation were inhibitory to S. Typhi: UPC, UP broth without sodium pyruvate (UPS), UP broth without ferric ammonium citrate (UPF), UP broth without MgSO4 (UPM), and UPI. It was found that none of the ingredients were inhibitory to S. Typhi and that, out of 140 total test portions, UPI and UPF, with 108 and 103 positive test portions, respectively, were significantly more effective (P<0.05) than the other UP broth formulations (82 for UPC, 74 for UPS, and 60 for UPM). Rather than being inhibitory to the growth of S. Typhi, it appears that ferric ammonium citrate enhanced the growth of competitors which suppressed the growth of S. Typhi. These results demonstrate that UPI and UPF are effective for the recovery of S. Typhi from mamey.
KW - analytical methods
KW - culture media
KW - food contamination
KW - fruits
KW - microbial contamination
KW - Pouteria sapota
KW - Salmonella typhi
KW - Pouteria
KW - Sapotaceae
KW - Ebenales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083062153&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: thomas.hammack@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Detection of ricin in food using electrochemiluminescence-based technology.
AU - Garber, E. A. E.
AU - O'Brien, T. W.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 2
SP - 376
EP - 382
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Garber, E. A. E.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Bioanalytical Chemistry, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20083114320. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Registry Number: 9009-86-3. Subject Subsets: Dairy Science
N2 - Ricin is a toxic ribosome inactivating protein (RIP-II) present in beans of the castor plant, Ricinus communis. Its potential as a biodefense threat has made the rapid, sensitive detection of ricin in food important to the U.S. Food and Drug Administration. Samples of juice, dairy products, soda, vegetables, bakery products, chocolate, and condiments were spiked with varying concentrations of ricin and analyzed using a 96-well format, electrochemiluminescence (ECL) immunoassay. Assay configurations included the use of a monoclonal capture antibody coupled with either a polyclonal or monoclonal detector antibody. The samples and detector antibodies were either added sequentially or in combination during the capture step. Using the polyclonal antibody, 0.04 ng/mL ricin was detected in analytical samples prepared from several beverages. By simultaneously incubating the sample with detector antibody, it was possible to decrease the assay time to a single 20 min incubation step with a limit of detection <10 ng/mL. Assays run according to this single incubation step exhibited a hook effect (decrease in signal at high concentrations of ricin), but because of the large signal-to-noise ratio associated with the ECL assay, the response remained above background and detectable. Thus, the ECL assay was uniquely suited for the screening of samples for ricin.
KW - analytical methods
KW - bakery products
KW - chemiluminescence immunoassays
KW - chocolate
KW - condiments
KW - food contamination
KW - fruit juices
KW - milk products
KW - ricin
KW - vegetables
KW - analytical techniques
KW - baked goods
KW - dairy products
KW - food contaminants
KW - vegetable crops
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083114320&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: Eric.Garber@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Single-laboratory validation of a method for the determination of furan in foods by using headspace gas chromatography/mass spectrometry, Part 2 - Low-moisture snack foods.
AU - Nyman, P. J.
AU - Morehouse, K. M.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
AU - Holcomb, J. R.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 2
SP - 414
EP - 421
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Nyman, P. J.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-706, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20083114312. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition
N2 - In 2004, a quantitative headspace (HS) gas chromatographic/mass spectrometric method was developed and used to determine furan in approximately 300 foods. This method was modified and validated for the determination of furan in low-moisture snack foods. The modifications include a smaller test portion size and lower HS oven temperature. The limits of detection ranged from 0.4 ng/g in graham crackers to 4.4 ng/g in pretzels. Recoveries from samples fortified at 0.5, 1, 2, and 3 times the levels of incurred furan found in the samples ranged from 96 to 102%, and HorRat values showed that the recovery data met the criteria for repeatability. The modified method was shown to be reliable for the determination of furan in foods when test portions were equilibrated for 30 min in a 60°C HS oven. The modified method was used to conduct a survey of furan in 22 low-moisture snack foods. All of the samples were found to contain furan ranging from 3.7 ng/g in graham crackers to 60 ng/g in corn chips. Results from the survey were consistent with results obtained for similar snack foods analyzed by a U.S. Food and Drug Administration field laboratory.
KW - analytical methods
KW - bakery products
KW - crackers
KW - food contamination
KW - furans
KW - GC-MS
KW - snacks
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - baked goods
KW - food contaminants
KW - gas chromatography-mass spectrometry
KW - United States of America
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083114312&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: patricia.nyman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - A rapid multiresidue method for determination of pesticides in fruits and vegetables by using acetonitrile extraction/partitioning and solid-phase extraction column cleanup.
AU - Schenck, F. J.
AU - Brown, A. N.
AU - Podhorniak, L. V.
AU - Parker, A.
AU - Reliford, M.
AU - Wong, J. W.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 2
SP - 422
EP - 438
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Schenck, F. J.: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309, USA.
N1 - Accession Number: 20083114313. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Horticultural Science; Agricultural Entomology; Postharvest Research
N2 - A modification of a rapid and inexpensive multiresidue method for determination of pesticides in fruits and vegetables (QuEChERS method) is presented. Samples were extracted by shaking with acetic acid-acetonitrile (1+99). Water was removed by liquid-liquid partitioning with magnesium sulfate and sodium acetate. The extract was subjected to a single solid-phase extraction (SPE) column cleanup, which produced a cleaner extract than did the dispersive SPE cleanup used in the original QuEChERS method. Recovery data were obtained for 316 pesticide residues, at levels ranging from 20 ppb to 1.0 ppm. Data were provided by 3 different laboratories. The modified QuEChERS method resulted in a 65% reduction in solvent usage, when compared to the traditional multiresidue methods previously used in our laboratories.
KW - analytical methods
KW - food safety
KW - fruits
KW - pesticide residues
KW - pesticides
KW - vegetables
KW - analytical techniques
KW - vegetable crops
KW - Horticultural Crops (FF003) (New March 2000)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083114313&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: Frank.Schenck@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of albendazole and its metabolites in the muscle tissue of hybrid striped and largemouth bass using liquid chromatography with fluorescence detection.
AU - Rummel, N.
AU - Shaikh, B.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 2
SP - 469
EP - 477
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Rummel, N.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd, Laurel, MD 20708, USA.
N1 - Accession Number: 20083114316. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Registry Number: 54965-21-8. Subject Subsets: Helminthology
N2 - A liquid chromatographic method was developed for the determination of albendazole and its metabolites albendazole sulfoxide, albendazole sulfone, and albendazole-2-aminosulfone from largemouth and hybrid striped bass muscle tissue with adhering skin. The muscle tissue samples were made alkaline with potassium carbonate and extracted with ethyl acetate. The extracts were further subjected to cleanup by using a series of liquid-liquid extractions. After solvent evaporation, the residue was reconstituted in mobile phase and chromatographed. The chromatography was carried out on a reversed-phase Luna C18 column, using acetonitrile-methanol buffer as the mobile phase. The analytes were detected by fluorescence with excitation and emission wavelengths of 290 and 330 nm, respectively. The average recoveries from the fortified muscle tissue of the 2 fish species for albendazole (25-100 ppb), albendazole sulfoxide (8.75-52.5 ppb), albendazole sulfone (1-10 ppb), and albendazole-2-aminosulfone (10-100 ppb) were 89, 82, 99, and 74%, respectively. The coefficient of variation for each compound was <20% in all cases. The procedure was applied to the determination of albendazole and its 3 metabolites in the muscle tissue of the 2 fish species after orally dosing them with albendazole.
KW - albendazole
KW - anthelmintics
KW - antibiotic residues
KW - drug residues
KW - fluorescence
KW - food contamination
KW - liquid chromatography
KW - metabolites
KW - muscle tissue
KW - bass
KW - Perciformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - food contaminants
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083114316&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: badaruddin.shaikh@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Single-laboratory validated method for determination of nordihydroguaiaretic acid in chaparral-containing dietary supplements.
AU - Gay, M. L.
AU - Musser, S. M.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 3
SP - 501
EP - 505
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Gay, M. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-707, 5100 Paint Branch Pkwy, College Park, MD 20770, USA.
N1 - Accession Number: 20083163111. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 500-38-9. Subject Subsets: Human Nutrition
N2 - Nordihydroguaiaretic acid (NDGA) occurs naturally in chaparral (Larrea tridentate Coville), a plant which commonly grows in the Southwest United States and has been used for medicinal purposes by Native Americans indigenous to that region. In addition to its traditional use as a tea, manufacturers of dietary supplements have marketed chaparral-containing products in a variety of formulations. Because of the hepatotoxicity of NDGA, and its occurrence in regulated products, we have developed a method for the determination of NDGA in dietary supplements and have tested this method in several dietary supplement formulations. Products were extracted with 80% methanol, filtered, and analyzed by high-performance liquid chromatography. NDGA was detected and determined with both a diode array detector and negative-ion electrospray. Fragmentation in the triple-quadrupole mass spectrometer was obtained by collisional activation of the [M-H]- ion. Collisional activation produced sufficient fragmentation to provide unambiguous identification. Lack of a stable isotope labeled internal standard has led us to compare quantitations based on UV detection with quantitations based on tandem mass spectrometry (MS/MS). Presence of NDGA was confirmed in several dietary supplement products. Quantitative results from the 2 detection methods were comparable for most products. The limit of quantitation using MS/MS was lower and fewer interferences were observed, although UV detection provided better linearity.
KW - analytical methods
KW - antioxidants
KW - determination
KW - mass spectrometry
KW - nordihydroguaiaretic acid
KW - techniques
KW - Larrea tridentata
KW - Larrea
KW - Zygophyllaceae
KW - Sapindales
KW - Geraniales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083163111&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: Martha.Gay@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of aflatoxins B1, B2, G1, and G2 and ochratoxin A in ginseng and ginger by multitoxin immunoaffinity column cleanup and liquid chromatographic quantitation: collaborative study.
AU - Trucksess, M. W.
AU - Weaver, C. M.
AU - Oles, C. J.
AU - Fry, F. S., Jr.
AU - Noonan, G. O.
AU - Betz, J. M.
AU - Rader, J. I.
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 3
SP - 511
EP - 523
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Trucksess, M. W.: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20083163113. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research; Aromatic & Medicinal Plants
N2 - The accuracy, repeatability, and reproducibility characteristics of a method using multitoxin immunoaffinity column cleanup with liquid chromatography (LC) for determination of aflatoxins (AF; sum of aflatoxins B1, B2, G1, and G2) and ochratoxin A (OTA) in powdered ginseng and ginger have been established in a collaborative study involving 13 laboratories from 7 countries. Blind duplicate samples of blank, spiked (AF and OTA added) at levels ranging from 0.25 to 16.0 µg/kg for AF and 0.25 to 8.0 µg/kg for OTA were analyzed. A naturally contaminated powdered ginger sample was also included. Test samples were extracted with methanol and 0.5% aqueous sodium hydrogen carbonate solution (700+300, v/v). The extract was centrifuged, diluted with phosphate buffer (PB), filtered, and applied to an immunoaffinity column containing antibodies specific for AF and OTA. After washing the column with water, the toxins were eluted from the column with methanol, and quantified by high-performance LC with fluorescence detection. Average recoveries of AF from ginseng and ginger ranged from 70 to 87% (at spiking levels ranging from 2 to 16 µg/kg), and of OTA, from 86 to 113% (at spiking levels ranging from 1 to 8 µg/kg). Relative standard deviations for within-laboratory repeatability (RSDr) ranged from 2.6 to 8.3% for AF, and from 2.5 to 10.7% for OTA. Relative standard deviations for between-laboratory reproducibility (RSDR) ranged from 5.7 to 28.6% for AF, and from 5.5 to 10.7% for OTA. HorRat values were ≤2 for the multi-analytes in the 2 matrixes.
KW - aflatoxins
KW - analytical methods
KW - determination
KW - food contamination
KW - food safety
KW - ginger
KW - HPLC
KW - mycotoxins
KW - ochratoxins
KW - techniques
KW - Panax ginseng
KW - Zingiber
KW - Panax
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - analytical techniques
KW - Araliales
KW - food contaminants
KW - fungal toxins
KW - high performance liquid chromatography
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083163113&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: mary.trucksess@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.
AU - Choi DongMi
AU - Park SangAeh
AU - Yoon TaeHyung
AU - Jeong HyeKyoung
AU - Pyo JaeSung
AU - Park JangHyun
AU - Kim DeukJoon
AU - Kwon SungWon
T2 - Journal of AOAC International
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 3
SP - 580
EP - 588
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Choi DongMi: Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122704, Korea Republic.
N1 - Accession Number: 20083163116. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They were isolated by preparative LC; their structures were established by mass spectrometry and nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is a sildenafil analog with a dimethylpiperazine ring substituted for the methylpiperazine group. The second analog, hydroxyvardenafil (compound B) is reported for the first time in this study. Hydroxyvardenafil's International Union of Pure and Applied Chemistry name is 2-(2-ethoxy-5-(4-(2-hydroxyethyl)-piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one. The novel vardenafil analog has a hydroxyl group added to the ethylpiperazine group.
KW - analogues
KW - analytical methods
KW - determination
KW - liquid chromatography
KW - mass spectrometry
KW - techniques
KW - analogs
KW - analytical techniques
KW - sildenafil
KW - vardenafil
KW - Pesticides and Drugs; Chemistry and Formulation (HH420) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083163116&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: swkwon@snu.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of sample preparation methods for the isolation of Salmonella from alfalfa and mung bean seeds with the Bacteriological Analytical Manual's Salmonella culture method.
AU - Jacobson, A. P.
AU - Hammack, T. S.
AU - Andrews, W. H.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008///
VL - 91
IS - 5
SP - 1083
EP - 1089
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Jacobson, A. P.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20083297634. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Subject Subsets: Human Nutrition
N2 - Five pre-enrichment methods were evaluated for effectiveness with the U.S. Food and Drug Administration's Bacteriological Analytical Manual Salmonella culture method in recovering S. Stanley, S. Poona, and S. Muenchen from artificially contaminated alfalfa seeds, and S. Saintpaul, S. Anatum, and S. Infantis from artificially contaminated mung bean seeds. The methods included: (1) Soak. - Test portions were inoculated into pre-enrichment media; (2) Rinse. - Test portions were rinsed with pre-enrichment media, and the media was decanted from the test portions; (3) Rinsed seed. - Pre-enrichment media was added to the test portions that were rinsed in the rinse method; (4) Wet blend. - Test portions were blended with the pre-enrichment media; and (5) Dry blend. - Test portions were blended prior to pre-enrichment. The methods of pre-enrichment were also evaluated for effectiveness in recovering Pantoea agglomerans from alfalfa and mung bean seeds with a modified culture method for the recovery of Enterobacteriaceae from foods. The purpose of these studies was to provide a model for the recovery of Salmonella that may occur in seeds as a natural contaminant. The relative effectiveness of the soak method was consistently superior to the rinse method in isolating the selected Salmonella serovars from both seed types. Statistically, the rinsed seed method was as effective as the soak method in all trials, except 1 of 3, with S. Muenchen and alfalfa seeds (P>0.05). The relative effectiveness of the methods in isolating P. agglomerans from alfalfa and mung bean seeds was similar to that observed with the artificially contaminated test portions. The soak method was consistently the most effective method and the rinse method was consistently the most ineffective method. The rinsed seed, wet blend, and dry blend methods were also as effective as the soak method in all 3 trials with each seed type (P>0.05).
KW - food contamination
KW - food safety
KW - lucerne
KW - methodology
KW - microbial contamination
KW - mung beans
KW - sample processing
KW - Medicago
KW - Medicago sativa
KW - Pantoea agglomerans
KW - Salmonella
KW - Salmonella Anatum
KW - Vigna radiata
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Pantoea
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Vigna
KW - Medicago
KW - alfalfa
KW - bacterium
KW - food contaminants
KW - methods
KW - preparation of samples
KW - Salmonella infantis
KW - Salmonella muenchen
KW - Salmonella poona
KW - Salmonella saintpaul
KW - Salmonella stanley
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083297634&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: andrew.jacobson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis.
AU - Boehmer, J. L.
AU - Bannerman, D. D.
AU - Shefcheck, K.
AU - Ward, J. L.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2008///
VL - 91
IS - 11
SP - 4206
EP - 4218
CY - Savoy; USA
PB - American Dairy Science Association
SN - 0022-0302
AD - Boehmer, J. L.: US Food and Drug Administration Center for Veterinary Medicine, Laurel, MD 20708, USA.
N1 - Accession Number: 20083304451. Publication Type: Journal Article. Language: English. Registry Number: 9045-23-2, 9000-71-9. Subject Subsets: Dairy Science; Veterinary Science; Veterinary Science
N2 - The objectives of the current study were to profile changes in protein composition using 2-dimensional gel electrophoresis on whey samples from a group of 8 cows before and 18 h after infection with Escherichia coli and to identify differentially expressed milk proteins by peptide sequencing using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry post source decay. Only proteins present in whey fractions of all 8 cows were sequenced to avoid reporting a protein response unique to only a subset of infected cows. Despite the overwhelming presence of casein and β-lactoglobulin, the low abundance proteins transthyretin, lactadherin, β-2-microglobulin precursor, α-1-acid glycoprotein, and complement C3 precursor could be identified in whey samples from healthy cows. Whey samples at 18 h postinfection were characterized by an abundance of serum albumin, in spots of varying mass and isoelectric point, as well as increased transthyretin and complement C3 precursor levels. Also detected at 18 h postinoculation were the antimicrobial peptides cathelicidin, indolicidin, and bactenecin 5 and 7, and the proteins β-fibrinogen, α-2-HS-glycoprotein, S100-A12, and α-1-antiproteinase. Most notable was the detection of the acute phase protein -1-acid glycoprotein in mastitic whey samples, a result not previously reported. In contrast to methods used in previous proteomic analyses of bovine milk, the methods used in the current study enabled the rapid identification of milk proteins with minimal sample preparation. Use of a larger sample size than previous analyses also allowed for more robust protein identification. Results indicate that examination of the protein profile of whey samples from cows after inoculation with E. coli could provide a rapid survey of milk protein modulation during coliform mastitis and aid in the identification of biomarkers of this disease.
KW - albumins
KW - analysis
KW - antimicrobial properties
KW - beta-lactoglobulin
KW - blood chemistry
KW - blood serum
KW - casein
KW - coliform bacteria
KW - cows
KW - detection
KW - electrophoresis
KW - globulins
KW - glycoproteins
KW - infections
KW - mass spectrometry
KW - mastitis
KW - milk
KW - milk proteins
KW - peptides
KW - proteins
KW - serum albumin
KW - surveys
KW - techniques
KW - whey
KW - cattle
KW - Escherichia
KW - Escherichia coli
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Escherichia
KW - anti-microbial properties
KW - bacterium
KW - E. coli
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Animal Physiology and Biochemistry (Excluding Nutrition) (LL600)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083304451&site=ehost-live&scope=site
UR - http://jds.fass.org/cgi/content/abstract/91/11/4206
UR - email: jamie.boehmer@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells.
AU - Lee, H. C.
AU - Kioi, M.
AU - Han, J.
AU - Puri, R. K.
AU - Goodman, J. L.
JO - Genomics (San Diego)
JF - Genomics (San Diego)
Y1 - 2008///
VL - 92
IS - 3
SP - 144
EP - 151
CY - San Diego; USA
PB - Elsevier Academic Press
SN - 0888-7543
AD - Lee, H. C.: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083249899. Publication Type: Journal Article. Language: English. Number of References: 58 ref. Subject Subsets: Medical & Veterinary Entomology; Public Health; Agricultural Biotechnology
N2 - Anaplasma phagocytophilum (Ap), the etiologic agent of the tick-borne disease human granulocytic anaplasmosis, is an obligate intracellular pathogen unique in its ability to target and replicate within neutrophils. We define and compare the spectra of host gene expression in response to Ap infection of human neutrophils and of HL-60 cells using long (70-mer)-oligonucleotide array technology. In addition to apoptosis-related genes, genes involved in signaling pathways, transcriptional regulation, immune response, host defense, cell adhesion, and cytoskeleton were modulated in neutrophils infected with Ap. Ap infection affected the same pathways in HL-60 cells but transcriptional changes occurred more slowly and in a reduced spectrum of genes. Gene expression changes detected by microarray were confirmed for randomly selected genes by QRT-PCR and Western blot studies. These studies demonstrate for the first time that the ERK pathway is activated in Ap-infected neutrophils and also define multiple pathways that are activated during intracellular Ap infection, which together serve to prolong the cell survival that is needed to allow bacterial replication and survival in neutrophils, which otherwise would rapidly apoptose.
KW - cell lines
KW - gene expression
KW - genes
KW - neutrophils
KW - Anaplasma
KW - Anaplasma phagocytophilum
KW - man
KW - Anaplasmataceae
KW - Rickettsiales
KW - Alphaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Anaplasma
KW - bacterium
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083249899&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WG1-4SXRYBS-1&_user=6686535&_coverDate=09%2F30%2F2008&_rdoc=4&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236809%232008%23999079996%23696201%23FLA%23display%23Volume)&_cdi=6809&_sort=d&_docanchor=&_ct=8&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=10a79fe9f88845ab4b1c747cd52a9a35
UR - email: jesse.goodman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Racial/ethnic minority children's use of psychiatric emergency care in California's public mental health system.
AU - Snowden, L. R.
AU - Masland, M. C.
AU - Libby, A. M.
AU - Wallace, N.
AU - Fawley, K.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2008///
VL - 98
IS - 1
SP - 118
EP - 124
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Snowden, L. R.: Center for Mental Health Services Research, School of Social Welfare, University of California, 120 Haviland Hall, Berkeley, CA 94720-7400, USA.
N1 - Accession Number: 20083066977. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - Objectives. We examined rates and intensity of crisis services use by race/ethnicity for 351174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. Methods. We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). Results. African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. Conclusions. African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits.
KW - adolescents
KW - American indians
KW - anxiety
KW - blacks
KW - children
KW - depression
KW - ethnic groups
KW - ethnicity
KW - health services
KW - Hispanics
KW - human diseases
KW - mental disorders
KW - mental health
KW - minorities
KW - psychoses
KW - whites
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - African-Americans
KW - attention deficit disorder with hyperactivity
KW - ethnic differences
KW - mental illness
KW - psychiatric disorders
KW - psychotic disorders
KW - teenagers
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083066977&site=ehost-live&scope=site
UR - email: snowden@berkeley.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multivariate analysis of state variation in breastfeeding rates in the United States.
AU - Kogan, M. D.
AU - Singh, G. K.
AU - Dee, D. L.
AU - Belanoff, C.
AU - Grummer-Strawn, L. M.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2008///
VL - 98
IS - 10
SP - 1872
EP - 1880
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Kogan, M. D.: Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083281662. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Dairy Science; Public Health
N2 - Objectives. We sought to determine the impact of sociodemographic and behavioral factors and state legislation on breastfeeding initiation (child ever fed breastmilk) and duration. Methods. We used data from a nationally representative study of children aged 6 to 71 months (N=33 121); we calculated unadjusted and adjusted state estimates for breastfeeding initiation and duration. We used logistic regression models to examine factors associated with never breastfeeding or breastfeeding less than 6 months. We conducted a multilevel analysis of state legislation's role. Results. There were wide state variations in breastfeeding initiation and duration. The western and northwestern states had the highest rates. Covariate adjustment accounted for 25% to 30% of the disparity. Multivariate analysis showed that the adjusted odds of not being breastfed were 2.5- to 5.15-times greater in southern states compared with Oregon (reference). Children in states without breastfeeding legislation had higher odds of not being breastfed. Conclusions. Sociodemographic and maternal factors do not account for most breastfeeding rate variation. The association with breastfeeding legislation should be explored and may reflect cultural norms.
KW - breast feeding
KW - children
KW - infants
KW - public health legislation
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083281662&site=ehost-live&scope=site
UR - email: mkogan@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - State-level health care access and use among children in US immigrant families.
AU - Yu, S. M.
AU - Huang, Z. J.
AU - Kogan, M. D.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2008///
VL - 98
IS - 11
SP - 1996
EP - 2003
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Yu, S. M.: Maternal and Child Health Bureau, HRSA, 5600 Fishers Lane, 18A-55, Rockville, MD 20857, USA.
N1 - Accession Number: 20083313851. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Subject Subsets: Public Health
N2 - Objectives. We examined the association between children's state of residence and their access to health care among specific types of immigrant families: foreign-born children, US-born children with 1 foreign-born parent, US-born children with both foreign-born parents, and nonimmigrant families. Methods. We analyzed data from 12400 children from the 2003 National Survey of Children's Health in the 6 states with the highest proportion of immigrants (California, Florida, Illinois, New York, New Jersey, and Texas). Results. Multivariable analyses indicated that among foreign-born children, those living in California, Illinois, and Texas were more likely to lack access to health care compared with those living in New York. Among foreign-born children with 1 or 2 US-born parents, Texas children were most likely to lack health insurance. Within nonimmigrant families, children from California, Florida, and Texas had significantly more access and use problems. Conclusions. Our findings document differential health care access and use among states for specific immigrant family types.
KW - children
KW - health care
KW - immigrants
KW - immigration
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Demography (UU200)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083313851&site=ehost-live&scope=site
UR - email: syu@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Racial/ethnic and gender differences in individual workplace injury risk trajectories: 1988-1998.
AU - Berdahl, T. A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2008///
VL - 98
IS - 12
SP - 2258
EP - 2263
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Berdahl, T. A.: Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850, USA.
N1 - Accession Number: 20093004432. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Objectives. I examined workplace injury risk over time and across racial/ethnic and gender groups to observe patterns of change and to understand how occupational characteristics and job mobility influence these changes. Methods. I used hierarchical generalized linear models to estimate individual workplace injury and illness risk over time ("trajectories") for a cohort of American workers who participated in the National Longitudinal Survey of Youth (1988-1998). Results. Significant temporal variation in injury risk was observed across racial/ethnic and gender groups. At baseline, White men had a high risk of injury relative to the other groups and experienced the greatest decline over time. Latino men demonstrated a pattern of lower injury risk across time compared with White men. Among both Latinos and non-Latino Whites, women had lower odds of injury than did men. Non-Latino Black women's injury risk was similar to Black men's and greater than that for both Latino and non-Latino White women. Occupational characteristics and job mobility partly explained these differences. Conclusions. Disparities between racial/ethnic and gender groups were dynamic and changed over time. Workplace injury risk was associated with job dimensions such as work schedule, union representation, health insurance, job hours, occupational racial segregation, and occupational environmental hazards.
KW - blacks
KW - epidemiology
KW - ethnicity
KW - Hispanics
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - risk factors
KW - safety at work
KW - sex differences
KW - trauma
KW - working hours
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - occupational safety
KW - traumas
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093004432&site=ehost-live&scope=site
UR - email: terceira.berdahl@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Structural model analysis of HIV risk behaviors among sexually active minority adolescents.
AU - Bellamy, N. D.
AU - Wang, M. Q.
AU - Matthew, R. F.
AU - Leitao, M. P.
AU - Agee, R. A.
AU - Yan, A. F.
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
Y1 - 2008///
VL - 100
IS - 8
SP - 914
EP - 924
CY - Washington; USA
PB - National Medical Association
SN - 0027-9684
AD - Bellamy, N. D.: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Prevention, Traumatic Stress and Special Programs, 1 Choke Cherry Road, Room 6-1003, Rockville, MD 20857, USA.
N1 - Accession Number: 20093082990. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health
N2 - Contents of this article are solely the responsibility of the authors and do not necessarily reflect the opinions, official policy or position of the U.S. Department of Health and Human Services, the Substance Abuse and Mental Health Services Administration or Centers for Mental Health Services and Substance Abuse Prevention. Objective: To evaluate an HIV risk profile in sexually active black and Hispanic adolescents using a structural equation model (SEM). Method: Grantees from 15 states and Washington, DC, were selected to participate in the study. Black and Hispanic adolescents (N=2,371) who completed the baseline instrument were required to have experienced vaginal, oral or anal sex in order to be included in this study. Total minority youths who self-reported as black but not Hispanic were n=1,455 and for Hispanic n=916. Results: The hypothesized model fit moderately well (CFI=0.940, TLI=0.928, RMSEA=0.039). The key significant direct effect was found (P<0.05) for higher alcohol, tobacco and other drug use related to nonuse of condoms, more sex partners and use of substances before sex. Conclusion: Current findings underscore the need to incorporate culturally sensitive strategies in developing programs for minority youth. However, given that minority group members often report greater experiences of discrimination than whites, future research in this area should also include an examination of the role of other stressors such as racial disparities and their potential cumulative impact on minority youth and their risks for alcohol, tobacco and other drug use and HIV.
KW - adolescents
KW - alcohol intake
KW - behaviour
KW - blacks
KW - children
KW - ethnic groups
KW - Hispanics
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - risk assessment
KW - risk behaviour
KW - risk factors
KW - sexual behaviour
KW - substance abuse
KW - tobacco smoking
KW - District of Columbia
KW - USA
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - behavior
KW - human immunodeficiency virus infections
KW - risk behavior
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - teenagers
KW - United States of America
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093082990&site=ehost-live&scope=site
UR - http://www.nmanet.org/images/uploads/Publications/OC914.pdf
UR - email: nikki.bellamy@samhsa.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Age-related crossover in breast cancer incidence rates between black and white ethnic groups.
AU - Anderson, W. F.
AU - Rosenberg, P. S.
AU - Menashe, I.
AU - Mitani, A.
AU - Pfeiffer, R. M.
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
Y1 - 2008///
VL - 100
IS - 24
SP - 1804
EP - 1814
CY - Cary; USA
PB - Oxford University Press
SN - 0027-8874
AD - Anderson, W. F.: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, EPS, Rm 8036, 6120 Executive Blvd, Bethesda, MD 20892-7244, USA.
N1 - Accession Number: 20093026804. Publication Type: Journal Article. Language: English. Number of References: 56 ref. Subject Subsets: Public Health
N2 - Background: Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact. Methods: To quantify this incidence rate crossover, we examined data for 440 653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided. Results: We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100 000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference=2.4, 95% confidence interval [CI]=2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference=41.8, 95% CI=41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P<.001 for difference by race). Conclusion: Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects.
KW - age differences
KW - blacks
KW - breast cancer
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - human diseases
KW - neoplasms
KW - women
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - ethnic differences
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093026804&site=ehost-live&scope=site
UR - http://jnci.oxfordjournals.org/cgi/content/full/100/24/1804
UR - email: wanderso@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contemporary identification of previously reported novel Cryptosporidium isolates reveals Cryptosporidium bovis and the cervine genotype in sheep (Ovis aries).
AU - Elwin, K.
AU - Chalmers, R. M.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2008///
VL - 102
IS - 5
SP - 1103
EP - 1105
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 0932-0113
AD - Elwin, K.: UK Cryptosporidium Reference Unit, National Public Health Service for Wales Microbiology Swansea, Singleton Hospital, Swansea, SA2 8QA, UK.
N1 - Accession Number: 20083138004. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health; Protozoology
N2 - Molecular characterisation of Cryptosporidium spp. from sheep (Ovis aries), sampled during the investigation of a waterborne outbreak of human cryptosporidiosis caused by Cryptosporidium parvum, previously established that the sheep were not the source of infection. At the time, a novel Cryptosporidium genotype was identified at the Cryptosporidium oocyst wall protein locus in 26 isolates and a further ten isolates amplified with heat shock protein primers but remained unidentified. Subsequent investigation of small subunit ribosomal DNA has revealed that 22 samples contained Cryptosporidium cervine genotype, five contained Cryptosporidium bovis and four samples contained both the cervine genotype and C. bovis.
KW - cryptosporidiosis
KW - diagnostic techniques
KW - genotypes
KW - human diseases
KW - molecular genetics techniques
KW - outbreaks
KW - Cryptosporidium
KW - Cryptosporidium parvum
KW - man
KW - sheep
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cryptosporidium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Ovis
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - Cryptosporidium bovis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083138004&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/g3x3r277u8437625/?p=cddf17ded0434373a682e317133bc751&pi=41
UR - email: Kristin.elwin@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aflatoxins contamination in spices and processed spice products commercialized in Korea.
AU - Cho SungHye
AU - Lee ChangHee
AU - Jang MiRan
AU - Son YoungWook
AU - Lee SangMok
AU - Choi InSun
AU - Kim SoHee
AU - Kim DaiByung
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008///
VL - 107
IS - 3
SP - 1283
EP - 1288
CY - Oxford; UK
PB - Elsevier
SN - 0308-8146
AD - Cho SungHye: Busan Regional Agency, Korea Food and Drug Administration, Busan 608-829, Korea Republic.
N1 - Accession Number: 20083020584. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Medical & Veterinary Mycology; Tropical Diseases
N2 - A survey for total aflatoxins (aflatoxins B1, B2, G1, and G2) was conducted on 88 spices and processed spice products commercialized in Korea. The presence of aflatoxins was determined by high-performance liquid chromatography (HPLC) with fluorescence detector using immunoaffinity column clean-up. Total aflatoxins (AFs) are detected in 12 samples (13.6% of incidence) including seven red pepper powder, two red pepper pastes (Kochujang), two curry and one ginger product. The contamination levels are 0.08-4.45 µg/kg as aflatoxin B1 and 0.08-4.66 µg/kg as AFs. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis on contaminated samples was conducted for the confirmation of detected aflatoxins. The 12 samples which showed aflatoxins by HPLC/FLD were confirmed as aflatoxins by LC-MS/MS.
KW - aflatoxins
KW - food contamination
KW - mycotoxins
KW - spices
KW - Korea Republic
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - aflatoxin B1
KW - aflatoxin B2
KW - aflatoxin G1
KW - aflatoxin G2
KW - food contaminants
KW - fungal toxins
KW - South Korea
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083020584&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03088146
UR - email: chang65@hanmail.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of multiple strains of Enterobacter sakazakii using fatty acid profiles.
AU - Hoffmann, M.
AU - Keys, C. E.
AU - Song, K. Y.
AU - Brown, E. W.
AU - Fry, F. S.
AU - Whittaker, P.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008///
VL - 107
IS - 4
SP - 1623
EP - 1628
CY - Oxford; UK
PB - Elsevier
SN - 0308-8146
AD - Hoffmann, M.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083021013. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Public Health; Human Nutrition
N2 - Fatty acid profiles are useful for identifying Gram-negative Enterobacter sakazakii strains within the family Enterobacteriaceae. The majority of cases of E. sakazakii infection have involved sepsis, meningitis, or enteritis, especially in neonates and infants. Gas chromatography with flame ionization detection (GC-FID) was utilized for the analysis of cellular fatty acid methyl esters (FAMEs). Thirty E. sakazakii strains isolated from food and environmental sources were cultured for 24 h on brain heart infusion (BHI) agar on three different days at 37°C. Whole cell FAMEs were obtained by saponification, methylation and extraction into hexane:methyl tert-butyl ether. The day to day variations for the 30 E. sakazakii strains for each fatty acid were determined. Gram-negative bacteria commonly contain combinations of straight-chain, unsaturated, hydroxyl, and cyclo fatty acids. Major fatty acids of E. sakazakii strains evaluated in this study were straight chain 12:0, 14:0, 16:0 and unsaturated 16:1, 18:1, and 17:0 ωcyclo 7-8. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by this rapid GC-FID method is highly reproducible and provides a sensitive procedure for identification of this organism. The fatty acid profile assay could be used to rapidly screen infant formula samples for E. sakazakii and reduce the time required for the current assay by up to 5 days.
KW - analytical methods
KW - bacterial diseases
KW - detection
KW - fatty acid esters
KW - fatty acids
KW - food contamination
KW - gas chromatography
KW - Gram negative bacteria
KW - human diseases
KW - ionization
KW - microbial contamination
KW - strain differences
KW - strains
KW - Bacteria
KW - Enterobacter sakazakii
KW - Bacteria
KW - prokaryotes
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - analytical techniques
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083021013&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03088146
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of headspace-SPME-GC-MS and LC-MS for the detection and quantification of coumarin, vanillin, and ethyl vanillin in vanilla extract products.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008///
VL - 107
IS - 4
SP - 1701
EP - 1709
CY - Oxford; UK
PB - Elsevier
SN - 0308-8146
AD - Jager, L. S. de: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20785, USA.
N1 - Accession Number: 20083021024. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Registry Number: 91-64-5, 121-33-5. Subject Subsets: Human Nutrition
N2 - A headspace-solid phase micro-extraction (HS-SPME) GC-MS method has been developed for the determination of coumarin, vanillin and ethyl vanillin in vanilla products. Limits of detection ranged from 1.33 to 13.2 ng mL-1. Accuracy and precision data for the method were measured and compared to those obtained using LC-ESI-MS. A survey of 24 commercially available vanilla products was completed using both techniques. No coumarin was detected in any of the samples. Examination of the GC-MS chromatograms revealed the presence of 18 other flavor related compounds in the samples. The method validation and sample analysis data using HS-SPME-GC-MS were comparable to those obtained using the LC-MS method. Because the two methods are conceptually different from one another, both methods would not be subject to the same interferences. This would allow them to be used as confirmatory methods for each other.
KW - analytical methods
KW - coumarin
KW - detection
KW - extraction
KW - GC-MS
KW - liquid chromatography
KW - mass spectrometry
KW - plant extracts
KW - plant products
KW - quantitative analysis
KW - vanillin
KW - Vanilla
KW - Orchidaceae
KW - Orchidales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - analytical techniques
KW - crop products
KW - gas chromatography-mass spectrometry
KW - Crop Produce (QQ050)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083021024&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03088146
UR - email: lowri.dejager@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Special Issue: An update on cancer in American Indians and Alaska Natives, 1999-2004.
AU - Cobb, N.
AU - Wingo, P. A.
AU - Edwards, B. K.
A2 - Cobb, N.
A2 - Wingo, P. A.
A2 - Edwards, B. K.
T2 - Cancer
JO - Cancer
JF - Cancer
Y1 - 2008///
VL - 113
IS - s5
SP - 1113
EP - 1273
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0008-543X
AD - Cobb, N.: Division of Epidemiology and Disease Prevention, Indian Health Service, 5300 Homestead NE, Albuquerque, NM 87110, USA.
N1 - Accession Number: 20083328813. Publication Type: Journal issue. Language: English. Subject Subsets: Public Health
N2 - The collection of papers in this Supplement combines cancer incidence data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results programme, enhanced by record linkages and geographic factors, to provide a comprehensive description of the cancer burden in the American Indian/Alaska Native (AI/AN) population in the USA. Cancer incidence rates among this population varied widely, sometimes more than 5-fold, by geographic region. Cancer incidence rates in AI/AN were lower than rates in non-Hispanic whites (NHW) for most cancer sites. Notable exceptions included higher rates of cancers occurring in the kidney, stomach, cervix uteri, liver, and gallbladder. Lung, colorectal and breast cancers occurred at rates higher or similar to the NHW population in Alaska and the Northern Plains, but were dramatically lower in the Southwest. Lung cancer tracks closely with the smoking rates in those regions.
KW - American Indians
KW - disease incidence
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - human diseases
KW - Inuit
KW - neoplasms
KW - surveillance
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - Eskimos
KW - ethnic differences
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083328813&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/121383359/issue
UR - email: nathaniel.cobb@ihs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged building.
AU - Park, J. H.
AU - Cox-Ganser, J. M.
AU - Kreiss, K.
AU - White, S. K.
AU - Rao, C. Y.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008///
VL - 116
IS - 1
SP - 45
EP - 50
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Park, J. H.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20083131847. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 57-87-4. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Background: Damp building-related respiratory illnesses are an important public health issue. Objective: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with postoccupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. Methods: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity ≥0.9), and ergosterol with the health outcomes using logistic regression models. Results: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR)=1.37-1.72], hydrophilic fungi (IQR-OR=1.45-2.19), and ergosterol (IQR-OR=1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR=2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR=1.54-1.55). Conclusions: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC: National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment. Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments.
KW - asthma
KW - buildings
KW - dust
KW - ergosterol
KW - exposure
KW - human diseases
KW - moulds
KW - personnel
KW - respiratory diseases
KW - USA
KW - fungi
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - lung diseases
KW - molds
KW - staff
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083131847&site=ehost-live&scope=site
UR - http://www.ehponline.org/docs/2007/10355/abstract.html
UR - email: gzp8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-κB, and Akt in normal and malignant human mesothelial cells.
AU - Pacurari, M.
AU - Yin, X. J.
AU - Zhao, J. S.
AU - Ding, M.
AU - Leonard, S. S.
AU - Shwegler-Berry, D.
AU - Ducatman, B. S.
AU - Sbarra, D.
AU - Hoover, M. D.
AU - Castranova, V.
AU - Vallyathan, V.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008///
VL - 116
IS - 9
SP - 1211
EP - 1217
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Pacurari, M.: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20083229920. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 1332-21-4, 9026-43-1. Subject Subsets: Public Health
N2 - Background: Single-wall carbon nanotubes (SWCNTs), with their unique physicochemical and mechanical properties, have many potential new applications in medicine and industry. There has been great concern subsequent to preliminary investigations of the toxicity, biopersistence, pathogenicity, and ability of SWCNTs to translocate to subpleural areas. These results compel studies of potential interactions of SWCNTs with mesothelial cells. Objective: Exposure to asbestos is the primary cause of malignant mesothelioma in 80-90% of individuals who develop the disease. Because the mesothelial cells are the primary target cells of asbestos-induced molecular changes mediated through an oxidant-linked mechanism, we used normal mesothelial and malignant mesothelial cells to investigate alterations in molecular signaling in response to a commercially manufactured SWCNT. Methods: In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species (ROS) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 (PARP-1), stimulation of extracellular signal-regulated kinase (ERKs), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor κB (NF-κB), and protein serine-threonine kinase (Akt). Results: Exposure to SWCNTs induced ROS generation, increased cell death, enhanced DNA damage and H2AX phosphorylation, and activated PARP, AP-1, NF-κB, p38, and Akt in a dose-dependent manner. These events recapitulate some of the key molecular events involved in mesothelioma development associated with asbestos exposure. Conclusions: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.
KW - apoptosis
KW - asbestos
KW - cell lines
KW - free radicals
KW - histones
KW - mesothelioma
KW - oxidative stress
KW - pentosyltransferases
KW - phosphorylation
KW - protein kinase
KW - reactive oxygen species
KW - transcription factors
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - activator protein 1
KW - carbon nanotubes
KW - DNA damage
KW - mesothelial cells
KW - mitogen-activated protein kinases
KW - NAD+ ADP-ribosyltransferase
KW - NF-kappa B
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083229920&site=ehost-live&scope=site
UR - http://www.ehponline.org/members/2008/10924/10924.html
UR - email: vav1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites.
AU - Gannavaram, S.
AU - Vedvyas, C.
AU - Debrabant, A.
T2 - Journal of Cell Science
JO - Journal of Cell Science
JF - Journal of Cell Science
Y1 - 2008///
VL - 121
IS - 1
SP - 99
EP - 109
CY - Cambridge; UK
PB - Company of Biologists Ltd
SN - 0021-9533
AD - Gannavaram, S.: Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083023256. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Protozoology; Public Health; Agricultural Biotechnology
N2 - Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the protozoan cell death pathways and the effector molecules involved in such processes remain to be identified. In this report, we describe the pro-apoptotic function of endonuclease G in trypanosomatid parasites. Similar to metazoans, trypanosome endoG showed intrinsic nuclease activity, is localized in mitochondria and is released from this organelle when cell death is triggered. Overexpression of endoG strongly promoted apoptotic cell death under oxidant or differentiation-related stress in Leishmania and, conversely, loss of endoG expression conferred robust resistance to oxidant-induced cell death in T. brucei. These data demonstrate the conservation of the pro-apoptotic endonuclease activity of endoG in these evolutionarily ancient eukaryotic organisms. Furthermore, nuclear DNA degradation by endoG upon release from mitochondria might represent a caspase-independent cell death mechanism in trypanosomatid parasites as genes encoding caspase-like proteins have not been identified in their genomes.
KW - African trypanosomiasis
KW - apoptosis
KW - enzyme activity
KW - genes
KW - human diseases
KW - leishmaniasis
KW - nucleases
KW - Leishmania
KW - Trypanosoma brucei
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Trypanosoma
KW - leishmaniosis
KW - sleeping sickness
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Genetics and Molecular Genetics (Wild Animals) (YY300) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083023256&site=ehost-live&scope=site
UR - http://jcs.biologists.org
UR - email: alain.debrabant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System.
AU - Ross, M. P.
AU - Ferguson, M.
AU - Street, D.
AU - Klontz, K.
AU - Schroeder, T.
AU - Luccioli, S.
T2 - Journal of Allergy and Clinical Immunology
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2008///
VL - 121
IS - 1
SP - 166
EP - 171
CY - New York; USA
PB - Elsevier
SN - 0091-6749
AD - Ross, M. P.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, FDA/CFSAN, HFS-014, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20083070684. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health; Human Nutrition
N2 - Background: The National Electronic Injury Surveillance System (NEISS) captures a nationally representative probability sample from hospital emergency departments (EDs) in the United States. Objective: Emergency department data from NEISS were analyzed to assess the magnitude and severity of adverse events attributable to food allergies. Methods: Emergency department events describing food-related allergic symptomatology were identified from 34 participating EDs from August 1 to September 30, 2003. Results: Extrapolation of NEISS event data predicts a total of 20,821 hospital ED visits, 2333 visits for anaphylaxis, and 520 hospitalizations caused by food allergy in the United States during the 2-month study period. The median age was 26 years; 24% of visits involved children ≤5 years old. Shellfish was the most frequently implicated food in persons ≥6 years old, whereas children ≤5 years old experienced more events from eggs, fruit, peanuts, and tree nuts. There were no reported deaths. Review of medical records found that only 19% of patients received epinephrine, and, using criteria established by a 2005 anaphylaxis symposium, 57% of likely anaphylactic events did not have an ED diagnosis of anaphylaxis. Conclusion: Analysis of NEISS data may be a useful tool for assessing the magnitude and severity of food-allergic events. A criteria-based review of medical records suggests underdiagnosis of anaphylactic events in EDs.
KW - anaphylaxis
KW - eggs
KW - food allergies
KW - fruits
KW - groundnuts
KW - human diseases
KW - shellfish
KW - surveillance
KW - USA
KW - Arachis hypogaea
KW - man
KW - Arachis
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - anaphylactic reactions
KW - anaphylactic shock
KW - food hypersensitivity
KW - peanuts
KW - United States of America
KW - Eggs and Egg Products (QQ040)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083070684&site=ehost-live&scope=site
UR - http://www.mosby.com/jaci
UR - email: Marianne.Ross@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Analytical bias of cross-reactive polyclonal antibodies for environmental immunoassays of Alternaria alternata.
AU - Schmechel, D.
AU - Green, B. J.
AU - Blachere, F. M.
AU - Janotka, E.
AU - Beezhold, D. H.
T2 - Journal of Allergy and Clinical Immunology
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2008///
VL - 121
IS - 3
SP - 763
EP - 768
CY - New York; USA
PB - Elsevier
SN - 0091-6749
AD - Schmechel, D.: Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20083107879. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Plant Pathology; Medical & Veterinary Mycology
N2 - Background: Alternaria alternata is recognized as an important aeroallergen indoors and outdoors, and exposure to the fungus has been identified as a risk factor for asthma. Two recent publications concluded that 95% to 99% of American homes contained detectable amounts of Alternaria antigens when analyzed with a polyclonal antibody (pAb)-based ELISA. Objectives: We investigated the cross-reactivity of the commercially available pAbs that were used in those studies. Methods: Reactivity to 24 fungal species commonly found in indoor environments was analyzed by inhibition ELISA by using solid-phase A. alternata antigen. The pAbs were also tested by immunoblotting and halogen immunoassay for a subgroup of fungi. Results: Spores of 7 fungi including species of Alternaria, Ulocladium, Stemphylium, Epicoccum, Drechslera, and Exserohilum strongly inhibited the binding of the pAbs when tested by ELISA. Six other fungi reacted in the ELISA at a lower level, and 11 fungal species including several Penicillium, Aspergillus, Fusarium, and Cladosporium species failed to show inhibition. The immunoblots and the halogen immunoassay staining confirmed the cross-reactivity patterns of the ELISA. Conclusion: The pAbs against A. alternata were found to cross-react broadly with related and nonrelated fungi. The prevalence data previously reported for A. alternata should be considered to be fungal-reactive rather than A. alternata-specific.
KW - allergens
KW - antibodies
KW - cross reaction
KW - fungal antigens
KW - fungal spores
KW - immunoassay
KW - Acremonium strictum
KW - Alternaria alternata
KW - Alternaria brassicae
KW - Aspergillus
KW - Cladosporium
KW - Cochliobolus lunatus
KW - Cochliobolus spicifer
KW - Drechslera
KW - Epicoccum nigrum
KW - Gibberella fujikuroi
KW - Hypocreaceae
KW - Microsphaeropsis
KW - Myrothecium verrucaria
KW - Paecilomyces variotii
KW - Penicillium chrysogenum
KW - Pleospora herbarum
KW - Pleosporaceae
KW - Ulocladium
KW - Acremonium
KW - Hypocreales
KW - Sordariomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Davidiellaceae
KW - Capnodiales
KW - Cochliobolus
KW - Epicoccum
KW - Gibberella
KW - Nectriaceae
KW - Myrothecium
KW - Paecilomyces
KW - Penicillium
KW - Pleospora
KW - Microascaceae
KW - Microascales
KW - Exserohilum
KW - Montagnulaceae
KW - Ulocladium
KW - Coelomycetes
KW - Doratomyces
KW - Doratomyces microsporus
KW - Exserohilum rostratum
KW - fungus
KW - Gibberella moniliformis
KW - Hyphomycetes
KW - Memnoniella
KW - Memnoniella echinata
KW - Microsphaeropsis olivacea
KW - Ulocladium botrytis
KW - Zygosporium
KW - Zygosporium masonii
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083107879&site=ehost-live&scope=site
UR - http://www.mosby.com/jaci
UR - email: DSchmechel@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
AU - Fein, S. B.
AU - Grummer-Strawn, L. M.
AU - Raju, T. N. K.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T2 - Pediatrics
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S25
EP - S120
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Fein, S. B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306800. Publication Type: Journal issue. Language: English. Registry Number: 7439-89-6. Subject Subsets: Dairy Science; Human Nutrition; Public Health
N2 - This supplement includes 13 papers presenting the first set of results from the Infant Feeding Practices Study II (IFPS II), which is a large-scale study of infant feeding and care practices conducted jointly by the Food and Drug Administration and the Centers for Disease Control and Prevention in the USA. The topics discussed are: study methodologies; infant feeding and feeding transitions; effect of maternity care practices on breastfeeding; employed women and breastfeeding practices; breast milk expression and associated factors; mothers' self-reported reasons for stopping breastfeeding; association of breastfeeding intensity and bottle-emptying behaviours at early infancy with excess weight/obesity at late infancy; complementary feeding practices and their association with maternal education; supplemental iron among breastfed infants; food allergies and other food-related health problems in infants; and infant sleeping arrangements and practices.
KW - behaviour
KW - bottle feeding
KW - breast feeding
KW - child care
KW - children
KW - education
KW - employed women
KW - food allergies
KW - food supplements
KW - food-related disorders
KW - human diseases
KW - human milk
KW - infant feeding
KW - infant nutrition
KW - infants
KW - iron
KW - lactating women
KW - lactation
KW - maternal behaviour
KW - methodology
KW - mothers
KW - obesity
KW - overweight
KW - sleep
KW - solid feeding
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - breast milk
KW - fatness
KW - food hypersensitivity
KW - maternal behavior
KW - methods
KW - United States of America
KW - working women
KW - Education and Training (CC100)
KW - Milk and Dairy Produce (QQ010)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Diet Studies (VV110)
KW - Physiology of Human Nutrition (VV120)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306800&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infant Feeding Practices Study II: study methods.
AU - Fein, S. B.
AU - Labiner-Wolfe, J.
AU - Shealy, K. R.
AU - Li, R.
AU - Chen, J.
AU - Grummer-Strawn, L. M.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S28
EP - S35
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Fein, S. B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306801. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 27 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - OBJECTIVE. Our goal is to describe the methods used in the Infant Feeding Practices Study II (IFPS II), a study of infant feeding and care practices throughout the first year of life. Survey topics included breastfeeding, formula and complementary feeding, infant health, breast-pump use, food allergies, sleeping arrangements, mother's employment, and child care arrangements. In addition, mothers' dietary intake was measured prenatally and postnatally. PARTICIPANTS AND METHODS. The IFPS II sample was drawn from a nationally distributed consumer opinion panel of 500000 households. All questionnaires were administered by mail, 1 prenatally and 10 postpartum. Qualifying criteria were used to achieve the sample goals of mothers of healthy term and late preterm singleton infants. In addition to the questionnaires about the infants, women were sent a diet-assessment questionnaire prenatally and at ~4 months after delivery; this questionnaire was also sent to members of a comparison group who were neither pregnant nor postpartum. RESULTS. A sample of 4902 pregnant women began the study, and ~2000 continued through their infant's first year. Response rates ranged from 63% to 87% for the different questionnaires. Compared with adult mothers of singletons from the nationally representative sample of the National Survey of Family Growth, IFPS II participants had a higher mean education level; were older; were more likely to be middle income, white, and employed; were less likely to smoke; and had fewer other children. Compared with women who participated in the National Immunization Survey who gave birth in 2004, IFPS II mothers were more likely to breastfeed and to breastfeed longer. CONCLUSIONS. The IFPS II provides a valuable database because of its large sample size, the frequency of its questionnaires, and its wide coverage of issues salient to infant feeding.
KW - age
KW - breast feeding
KW - education
KW - employment
KW - ethnic groups
KW - family size
KW - income
KW - infant feeding
KW - infants
KW - methodology
KW - mothers
KW - pregnancy
KW - questionnaires
KW - socioeconomic status
KW - tobacco smoking
KW - whites
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - gestation
KW - jobs
KW - methods
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306801&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Success of strategies for combining employment and breastfeeding.
AU - Fein, S. B.
AU - Mandal, B.
AU - Roe, B. E.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S56
EP - S62
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Fein, S. B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306805. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 37 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - OBJECTIVE. Return to work is associated with diminished breastfeeding intensity and duration. Although more mothers breastfeed after returning to work now than earlier, research has not documented the strategies that mothers use for combining paid work and breastfeeding or their effect on breastfeeding outcomes. This study examined which strategies are associated with smaller decrements in breastfeeding intensity and longer durations. PARTICIPANTS AND METHODS. We analyzed 810 mothers from the Infant Feeding Practices Study II who worked and breastfed. We used regression and censored regression models to analyze 4 strategies that mothers used to combine these 2 activities: (1) feed directly from the breast only; (2) both pump and feed directly; (3) pump only; and (4) neither pump nor breastfeed during the work day. Outcomes were the difference in percentage of milk feeds that were breast milk between the month before and after return to work and duration of breastfeeding after return to work. RESULTS. Forty-three percent of mothers pumped milk at work only; 32% fed the infant directly from the breast only. These 2 strategies, along with pumping and feeding directly, were statistically similar and superior to neither pumping nor breastfeeding during the work day for the outcome of change in breastfeeding intensity. For the outcome of breastfeeding duration, the 2 strategies that included directly feeding from the breast were associated with longer duration than pumping only, whereas the strategy of neither pumping nor breastfeeding during the work day was associated with the shortest duration. CONCLUSIONS. Feeding the infant from the breast during the work day is the most effective strategy for combining breastfeeding and work. Ways to enable direct feeding include on-site child care, telecommuting, keeping the infant at work, allowing the mother to leave work to go to the infant, and having the infant brought to the work site. Establishing ways for mothers to feed from the breast after return to work is important to meet US breastfeeding goals.
KW - breast feeding
KW - employed women
KW - infant feeding
KW - infants
KW - mothers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - working women
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306805&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of breast milk expression and associated factors.
AU - Labiner-Wolfe, J.
AU - Fein, S. B.
AU - Shealy, K. R.
AU - Wang, C.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S63
EP - S68
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Labiner-Wolfe, J.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306806. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 16 ref. Subject Subsets: Dairy Science
N2 - OBJECTIVES. Our goal was to describe the prevalence of any, occasional, and regular breast milk expression, mothers' reasons for expressing their milk, and sociodemographic factors associated with breast milk expression. PARTICIPANTS AND METHODS. Breastfeeding mothers participating in the 2005-2007 Infant Feeding Practices Study II formed the cohort for these analyses, which were conducted among those with infants in 3 age groups: 1.5 to 4.5 months (n=1564); >4.5 to 6.5 months (n=1128); and >6.5 to 9.5 months (n=914). For the analyses we used frequency and stepwise multiple logistic regression procedures. RESULTS. Eighty-five percent of breastfeeding mothers of infants in the youngest age group had successfully expressed milk at some time since their infant was born. When asked only about the previous 2-week period, 68% of the breastfeeding mothers of infants in this youngest age group had expressed milk, with 43% having done so occasionally and 25% on a regular schedule. Approximately one quarter of breastfeeding mothers of infants in the 2 older infant age groups also expressed milk on a regular schedule. The percentage of mothers expressing milk decreased with increasing infant age. Mothers expressed milk for various reasons. The most frequently cited reason was to get breast milk for someone else to feed their infant. In all 3 age groups, reporting any breast milk expression, compared with none, was positively associated with maternal employment, higher income, lack of previous breastfeeding experience, and living in the Midwest versus the West. In all 3 age groups, expressing milk on a regular schedule, compared with occasionally, was positively associated with maternal employment and the use of an electric versus manual breast pump. CONCLUSIONS. Breast milk expression is a very common practice. It is associated most strongly with maternal employment, a recognized barrier to breastfeeding.
KW - age
KW - breast feeding
KW - breast pumps
KW - employment
KW - human milk
KW - income
KW - infants
KW - lactating women
KW - lactation
KW - living conditions
KW - milk ejection
KW - mothers
KW - socioeconomic status
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - breast milk
KW - jobs
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083306806&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: judy.labiner@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infant formula-handling education and safety.
AU - Labiner-Wolfe, J.
AU - Fein, S. B.
AU - Shealy, K. R.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S85
EP - S90
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Labiner-Wolfe, J.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306809. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 13 ref. Subject Subsets: Dairy Science; Public Health
N2 - OBJECTIVES. Our goal was to assess the extent to which mothers learn about proper handling of infant formula from health professionals and package labels; mothers' beliefs about the likelihood of germs being in infant formula and the importance of following safe-use directions; whether they take measures while handling infant formula to prevent foodborne illnesses and injury to their infants; and maternal characteristics associated with unsafe infant formula-handling practices. PARTICIPANTS AND METHODS. The study cohort consisted of mothers participating in the 2005-2007 Infant Feeding Practices Study II who fed their infant formula. We conducted frequency and multiple logistic regression analyses. Sample sizes for the analyses ranged from 860 to 1533. RESULTS. The majority of formula-feeding mothers did not receive instruction on formula preparation (77%) or storage (73%) from a health professional. Thirty percent did not read some of the safe-use directions on the formula package label; an approximately equal percentage (38%) thought that both powdered (which is not sterile) and ready-to-feed (which is sterile) formula were unlikely to contain germs; and 85% believed that following safe-storage directions was very important. Among the mothers of the youngest infants analyzed, 55% did not always wash their hands with soap before preparing infant formula, 32% did not adequately wash bottle nipples between uses, 35% heated formula bottles in a microwave oven, and 6% did not always discard formula left standing for >2 hours. The prevalence of these unsafe practices was similar among mothers of older infants. No consistent pattern of maternal characteristics was associated with unsafe practices. CONCLUSIONS. Many mothers do not follow safe practices when preparing infant formula. Additional research is needed to understand why more mothers do not follow safe formula-handling recommendations.
KW - beliefs
KW - education
KW - food contamination
KW - food handling
KW - food hygiene
KW - food preparation
KW - food safety
KW - food storage
KW - infant formulae
KW - microbial contamination
KW - microorganisms
KW - milk
KW - mothers
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - micro-organisms
KW - United States of America
KW - Education and Training (CC100)
KW - Milk and Dairy Produce (QQ010)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
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UR - http://pediatrics.aappublications.org
UR - email: judy.labiner@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selected complementary feeding practices and their association with maternal education.
AU - Fein, S. B.
AU - Labiner-Wolfe, J.
AU - Scanlon, K. S.
AU - Grummer-Strawn, L. M.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S91
EP - S97
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Fein, S. B.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740, USA.
N1 - Accession Number: 20083306810. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 26 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - OBJECTIVE. As infants transition from a milk-based diet to one that includes most food groups, the timing of the transition, how infants are fed, and the quality of their diet can have important health implications. Our objective is to describe these factors for US infants. METHODS. We analyzed data from the Infant Feeding Practices Study II. Sample sizes varied for relevant questions from ~1600 to ~2400. We analyzed the prevalence of 14 feeding practices and their association with the mothers' education and also examined participants' use of commercial baby foods. RESULTS. Approximately 21% of the mothers introduced solid foods before 4 months; 7% introduced solids after 6 months. Twenty-nine percent of the mothers introduced >3 new foods per week to infants aged 5 to 10 months. Approximately 20% of the mothers fed juice before 6 months, fed cow's milk before 12 months, and fed infants <5 times per day after 5 months. Fourteen percent of the mothers chewed food for their infant. Approximately 15% of the mothers fed <1 serving daily of either a fruit or vegetable to infants aged ≥9 months, half added salt to their infant's food, and more than one third who added salt used noniodized salt. Approximately 20% fed reduced-fat cow's milk at 1 year. Almost half of the 10-month-old infants had eaten restaurant food in a restaurant in the previous week, 22% had eaten carry-out food, and 28% had eaten either type of restaurant food ≥2 times. The prevalence of 8 of the 14 unhealthful infant feeding practices we examined was inversely associated with maternal education. CONCLUSIONS. Nutrition and feeding guidance should be especially targeted to mothers with a high school education or less.
KW - education
KW - fast foods
KW - fruit
KW - infant feeding
KW - infant foods
KW - infants
KW - juices
KW - milk
KW - mothers
KW - salt
KW - solid feeding
KW - vegetables
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - baby foods
KW - United States of America
KW - vegetable crops
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Diet Studies (VV110)
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UR - http://pediatrics.aappublications.org
UR - email: sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Maternally reported food allergies and other food-related health problems in infants: characteristics and associated factors.
AU - Luccioli, S.
AU - Ross, M.
AU - Labiner-Wolfe, J.
AU - Fein, S. B.
A2 - Fein, S. B.
A2 - Grummer-Strawn, L. M.
A2 - Raju, T. N. K.
T3 - Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008///
VL - 122
SP - S105
EP - S112
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Luccioli, S.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 200, College Park, MD 20740, USA.
N1 - Accession Number: 20083306812. Publication Type: Journal Article. Note: Special Issue: Infant feeding and care practices in the United States. Results from the Infant Feeding Practices Study II. Language: English. Number of References: 40 ref. Subject Subsets: Human Nutrition; Public Health
N2 - OBJECTIVE. Our goal was to identify the frequency, demographics, and diagnostic characteristics associated with maternally reported food allergies and other food-related health problems among infants aged ≤1 year. METHODS. We analyzed data from the 2005-2007 Infant Feeding Practices Study II, a longitudinal survey of 2441 US mothers of healthy singletons from pregnancy through their infant's first year. Doctor diagnosis and symptoms-based criteria were used to identify a probable-food-allergic group from maternal reports of infant health problems with food. RESULTS. More than one fifth of the 2441 mothers reported that their infant had a food-related problem; 6% (n=143) had a probable food allergy, and 15% (n=359) had other food-related problems. Forty percent of the infants with a food-related health problem were evaluated by a doctor. Gastrointestinal symptoms were more commonly reported in early infancy compared with skin-related symptoms, which were reported in later infancy, and 27% received medical treatment for the symptoms. Characteristics associated with increased incidence of probable food allergy included family histories of food allergy and type 1 diabetes, gestational diabetes, living in rural or urban areas, being black, and being male. Among all infants with a food-related health problem, the majority experienced their first problem by 6 months of age. Foods recognized to be major allergens were most commonly reported as the source of an allergy. CONCLUSIONS. Food-related problems occurred at a high frequency in the first year of life. A better understanding of the demographics, family history, disease manifestations, and diagnoses may provide insight into public health efforts to minimize or prevent food allergies in infancy and to help differentiate food-allergic problems from nonallergic food problems in this age group.
KW - allergens
KW - blacks
KW - demography
KW - diabetes mellitus
KW - ethnic groups
KW - familial incidence
KW - food allergies
KW - food-related disorders
KW - human diseases
KW - infants
KW - medical treatment
KW - mothers
KW - sex
KW - surveys
KW - symptoms
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - food hypersensitivity
KW - gestational diabetes
KW - type 1 diabetes mellitus
KW - United States of America
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
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UR - http://pediatrics.aappublications.org
UR - email: stefano.luccioli@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protecting poultry workers from exposure to avian influenza viruses.
AU - MacMahon, K. L.
AU - Delaney, L. J.
AU - Kullman, G.
AU - Gibbins, J. D.
AU - Decker, J.
AU - Kiefer, M. J.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008///
VL - 123
IS - 3
SP - 316
EP - 322
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - MacMahon, K. L.: Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C32, 4676 Columbia Pkwy., Cincinnati, OH 45230, USA.
N1 - Accession Number: 20083125544. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science; Poultry
N2 - Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article.
KW - avian influenza
KW - avian influenza A viruses
KW - avian influenza viruses
KW - human diseases
KW - influenza viruses
KW - poultry
KW - poultry diseases
KW - public health
KW - viral diseases
KW - zoonoses
KW - fowls
KW - Influenza A virus
KW - man
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - Avian influenzavirus
KW - bird flu
KW - bird grippe
KW - bird influenza
KW - chickens
KW - domesticated birds
KW - fowl plague virus
KW - Influenzavirus
KW - viral infections
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083125544&site=ehost-live&scope=site
UR - http://www.publichealthreports.org
UR - email: KMacMahon@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimating infectious diseases incidence: validity of capture-recapture analysis and truncated models for incomplete count data.
AU - Hest, N. A. H. van
AU - Grant, A. D.
AU - Smit, F.
AU - Story, A.
AU - Richardus, J. H.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2008///
VL - 136
IS - 1
SP - 14
EP - 22
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Hest, N. A. H. van: Division of Infectious Disease Control, Municipal Public Health Service Rotterdam Area, PO Box 70032, 3000 LP, Rotterdam, Netherlands.
N1 - Accession Number: 20083044714. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Capture-recapture analysis has been used to evaluate infectious disease surveillance. Violation of the underlying assumptions can jeopardize the validity of the capture-recapture estimates and a tool is needed for cross-validation. We re-examined 19 datasets of log-linear model capture-recapture studies on infectious disease incidence using three truncated models for incomplete count data as alternative population estimators. The truncated models yield comparable estimates to independent log-linear capture-recapture models and to parsimonious log-linear models when the number of patients is limited, or the ratio between patients registered once and twice is between 0.5 and 1.5. Compared to saturated log-linear models the truncated models produce considerably lower and often more plausible estimates. We conclude that for estimating infectious disease incidence independent and parsimonious three-source log-linear capture-recapture models are preferable but truncated models can be used as a heuristic tool to identify possible failure in log-linear models, especially when saturated log-linear models are selected.
KW - disease incidence
KW - epidemiology
KW - human diseases
KW - infectious diseases
KW - linear models
KW - mathematical models
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - communicable diseases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083044714&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1585796&fulltextType=RA&fileId=S0950268807008254
UR - email: vanhestr@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence and completeness of notification of Legionnaires' disease in The Netherlands: covariate capture-recapture analysis acknowledging regional differences.
AU - Hest, N. A. H. van
AU - Hoebe, C. J. P. A.
AU - Boer, J. W. den
AU - Vermunt, J. K.
AU - Ijzerman, E. P. F.
AU - Boersma, W. G.
AU - Richardus, J. H.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2008///
VL - 136
IS - 4
SP - 540
EP - 550
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Hest, N. A. H. van: Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20083068798. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - To estimate incidence and completeness of notification of Legionnaires' disease (LD) in The Netherlands in 2000 and 2001, we performed a capture-recapture analysis using three registers: Notifications, Laboratory results and Hospital admissions. After record-linkage, 373 of the 780 LD patients identified were notified. Ascertained under-notification was 52.2%. Because of expected and observed regional differences in the incidence rate of LD, alternatively to conventional log-linear capture-recapture models, a covariate (region) capture-recapture model, not previously used for estimating infectious disease incidence, was specified and estimated 886 LD patients (95% confidence interval 827-1022). Estimated under-notification was 57.9%. Notified, ascertained and estimated average annual incidence rates of LD were 1.15, 2.42 and 2.77/100 000 inhabitants respectively, with the highest incidence in the southern region of The Netherlands. Covariate capture-recapture analysis acknowledging regional differences of LD incidence appears to reduce bias in the estimated national incidence rate.
KW - disease control
KW - epidemiology
KW - human diseases
KW - Legionnaires' disease
KW - Netherlands
KW - Legionella
KW - Legionellaceae
KW - Legionellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083068798&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1787136&fulltextType=RA&fileId=S0950268807008977
UR - email: vanhestr@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Estimating the coverage of a targeted mobile tuberculosis screening programme among illicit drug users and homeless persons with truncated models.
AU - Hest, N. A. H. van
AU - Vries, G. de
AU - Smit, F.
AU - Grant, A. D.
AU - Richardus, J. H.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2008///
VL - 136
IS - 5
SP - 628
EP - 635
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Hest, N. A. H. van: Tuberculosis Control Section, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20083097979. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Truncated models are indirect methods to estimate the size of a hidden population which, in contrast to the capture-recapture method, can be used on a single information source. We estimated the coverage of a tuberculosis screening programme among illicit drug users and homeless persons with a mobile digital X-ray unit between 1 January 2003 and 31 December 2005 in Rotterdam, The Netherlands, using truncated models. The screening programme reached about two-third of the estimated target population at least once annually. The intended coverage (at least two chest X-rays per person per year) was about 23%. We conclude that simple truncated models can be used relatively easily on available single-source routine data to estimate the size of a population of illicit drug users and homeless persons. We assumed that the most likely overall bias in this study would be overestimation and therefore the coverage of the targeted mobile tuberculosis screening programme would be higher.
KW - diagnosis
KW - drug users
KW - health care
KW - health services
KW - homeless people
KW - human diseases
KW - public health
KW - risk groups
KW - screening
KW - tuberculosis
KW - Netherlands
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - bacterium
KW - drug abusers
KW - screening tests
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083097979&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1815476&fulltextType=RA&fileId=S0950268807009235
UR - email: vanhestr@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Record-linkage and capture-recapture analysis to estimate the incidence and completeness of reporting of tuberculosis in England 1999-2002.
AU - Hest, N. A. H. van
AU - Story, A.
AU - Grant, A. D.
AU - Antoine, D.
AU - Crofts, J. P.
AU - Watson, J. M.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2008///
VL - 136
IS - 12
SP - 1606
EP - 1616
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Hest, N. A. H. van: Tuberculosis Control Section, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20083307244. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - In 1999 the Enhanced Tuberculosis Surveillance (ETS) system was introduced in the United Kingdom to strengthen surveillance of tuberculosis (TB). The aim of this study was to assess the use of record-linkage and capture-recapture methodology for estimating the completeness of TB reporting in England between 1999 and 2002. Due to the size of the TB data sources sophisticated record-linkage software was required and the proportion of false-positive cases among unlinked hospital-derived TB records was estimated through a population mixture model. This study showed that record-linkage of TB data sources and cross-validation with additional TB-related datasets improved data quality as well as case ascertainment. Since the introduction of ETS observed completeness of notification in England has increased and the results were consistent with expected levels of under-notification. Completeness of notification estimated by a log-linear capture-recapture model was highly inconsistent with prior estimates and the validity of this methodology was further examined.
KW - computer software
KW - disease prevalence
KW - epidemiology
KW - estimates
KW - estimation
KW - human diseases
KW - mathematical models
KW - mycobacterial diseases
KW - public health
KW - respiratory diseases
KW - tuberculosis
KW - England
KW - UK
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - bacterium
KW - Britain
KW - computer programs
KW - estimations
KW - lung diseases
KW - mycobacterial infections
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083307244&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=HYG
UR - email: vanhestr@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Concentrations of saxitoxin and tetrodotoxin in three species of puffers from the Indian River Lagoon, Florida, the location for multiple cases of saxitoxin puffer poisoning from 2002 to 2004.
AU - Deeds, J. R.
AU - White, K. D.
AU - Etheridge, S. M.
AU - Landsberg, J. H.
JO - Transactions of the American Fisheries Society
JF - Transactions of the American Fisheries Society
Y1 - 2008///
VL - 137
IS - 5
SP - 1317
EP - 1326
CY - Philadelphia; USA
PB - Taylor and Francis
SN - 0002-8487
AD - Deeds, J. R.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20723, USA.
N1 - Accession Number: 20123007003. Publication Type: Journal Article. Language: English. Subject Subsets: Horticultural Science; Human Nutrition
N2 - In response to multiple, unexpected cases of saxitoxin poisoning that started in January 2002, southern puffers Sphoeroides nephelus, checkered puffers S. testudineus, and bandtail puffers S. spengleri were collected from April to August 2002 from several locations in the Indian River Lagoon (IRL), Florida. Fish were analyzed for saxitoxin (STX) and tetrodotoxin (TTX) content in muscle, liver, and gonad tissues by means of the liquid chromatography-electrospray ionization-mass spectrometry method in multiple reactions monitoring mode. Spatial, species, and tissue-specific differences in toxin content and composition were found among these puffer species in the IRL. Southern puffers from the northern IRL had the highest concentrations of STX, muscle being the most contaminated tissue (1,770±159 µg/100 g tissue [mean±SD]; n=3). Southern puffers from the Banana River and central IRL had lower amounts of STX in all tissues tested. Nearly all southern puffer tissues tested had only trace amounts of TTX. Both checkered and bandtail puffers from the central and southern IRL had higher concentrations of TTX than of STX in all tissues, checkered puffer livers being the most toxic (6,075±3,283 µg/100 g tissue; n=3). For comparison, U.S. mid-Atlantic northern puffers S. maculatus (n=10) were tested and found to contain no detectable amounts of STX or TTX. This research confirms that STX and not TTX was responsible for 28 poisoning cases in southern puffers from the northern IRL between 2002 and 2004, and it describes for the first time the relative distribution of STX and TTX in U.S. East Coast puffers.
KW - bananas
KW - contamination
KW - liver
KW - monitoring
KW - muscles
KW - poisoning
KW - toxins
KW - Florida
KW - USA
KW - Musa
KW - Sphoeroides
KW - Musaceae
KW - Zingiberales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Sphoeroides
KW - Tetraodontidae
KW - Tetraodontiformes
KW - Osteichthyes
KW - fishes
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - Sphoeroides testudineus
KW - surveillance systems
KW - toxicosis
KW - United States of America
KW - Crop Produce (QQ050)
KW - Horticultural Crops (FF003) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20123007003&site=ehost-live&scope=site
UR - http://www.tandfonline.com/doi/abs/10.1577/T07-204.1
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells.
AU - Smith, J. S.
AU - Xu, Z.
AU - Byrnes, A. P.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008///
VL - 147
IS - 1
SP - 54
EP - 60
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Smith, J. S.: Division of Cellular and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083036469. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad. A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and computerized image analysis. The method is sensitive, quantitative and reproducible, with a linear range spanning two orders of magnitude. As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%.
KW - cell cultures
KW - quantitative analysis
KW - quantitative techniques
KW - Adenoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083036469&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal01660934
UR - email: JeffreyS.Smith@fda.hhs.gov\Zhili.Xu@fda.hhs.gov\Andrew.Byrnes@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for bacterial vaginosis in pregnancy to prevent preterm delivery: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 148
IS - 3
SP - 214
EP - 219
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083035863. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2001 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for bacterial vaginosis in pregnancy. Methods: The USPSTF weighed the benefits and harms of screening for bacterial vaginosis in pregnancy by identifying new evidence addressing previously identified gaps from the 2001 USPSTF recommendation. Published literature on this topic was identified by using MEDLINE, Cochrane Library databases, the Database of Abstracts of Reviews of Effects, reference lists, and consultation with experts and was systematically reviewed. When data allowed, a series of meta-analyses (using new and 2001 report data) was done to estimate the pooled effect of treatment on preterm delivery (<37 weeks, <34 weeks, or <32 weeks) and on low birthweight and preterm, premature rupture of membranes. Recommendation: Do not screen for bacterial vaginosis in pregnant women at low risk for preterm delivery. (D recommendation) Current evidence is insufficient to assess the balance of benefits and harms of screening for bacterial vaginosis in pregnant women at high risk for preterm delivery.
KW - antibacterial agents
KW - antibiotics
KW - bacterial diseases
KW - bacterial vaginitis
KW - childbirth
KW - disease prevention
KW - drug therapy
KW - guidelines
KW - human diseases
KW - pregnancy
KW - screening
KW - vagina
KW - women
KW - USA
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterial vaginosis
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - gestation
KW - premature birth
KW - recommendations
KW - screening tests
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083035863&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for chronic obstructive pulmonary disease using spirometry: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 148
IS - 7
SP - 529
EP - 534
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083085561. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - Description: New U.S. Preventive Services Task Force (USPSTF) recommendation about screening for chronic obstructive pulmonary disease (COPD) using spirometry. Methods: The USPSTF weighed the benefits (prevention of ≥1 exacerbation and improvement in respiratory-related health status measures) and harms (time and effort required by both patients and the health care system, false-positive screening tests, and adverse effects of subsequent unnecessary therapy) of COPD screening identified in the accompanying review of the evidence. The USPSTF did not consider the financial costs of spirometry testing or COPD therapies. Recommendation: Do not screen adults for COPD using spirometry. (Grade D recommendation).
KW - chronic obstructive pulmonary disease
KW - diagnostic techniques
KW - guidelines
KW - health services
KW - human diseases
KW - lung function
KW - respiratory diseases
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lung diseases
KW - recommendations
KW - screening tests
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083085561&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for chronic obstructive pulmonary disease using spirometry: summary of the evidence for the U.S. Preventive Services Task Force.
AU - Lin, K.
AU - Watkins, B.
AU - Johnson, T.
AU - Rodriguez, J. A.
AU - Barton, M. B.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 148
IS - 7
SP - 535
EP - 543
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Lin, K.: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20083085562. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Public Health
N2 - Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Fewer than half of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and diagnosis often occurs in advanced stages of the disease. Purpose: To summarize the evidence on screening for COPD using spirometry for the U.S. Preventive Services Task Force (USPSTF). Data Sources: English-language articles identified in PubMed and the Cochrane Library through January 2007, recent systematic reviews, expert suggestions, and reference lists of retrieved articles. Study Selection: Explicit inclusion and exclusion criteria were used for each of the 8 key questions on benefits and harms of screening. Eligible study types varied by question. Data Extraction: Studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: Pharmacologic treatments for COPD reduce acute exacerbations in patients with severe disease. However, severe COPD is uncommon in the general U.S. population. Spirometry has not been shown to independently increase smoking cessation rates. Potential harms from screening include false-positive results and adverse effects from subsequent unnecessary therapy. Data on the prevalence of airflow obstruction in the U.S. population were used to calculate projected outcomes from screening groups defined by age and smoking status. Limitation: No studies provide direct evidence on health outcomes associated with screening for COPD. Conclusion: Screening for COPD using spirometry is likely to identify a predominance of patients with mild to moderate airflow obstruction who would not experience additional health benefits if labeled as having COPD. Hundreds of patients would need to undergo spirometry to defer a single exacerbation.
KW - chronic obstructive pulmonary disease
KW - diagnostic techniques
KW - human diseases
KW - lung function
KW - respiratory diseases
KW - reviews
KW - screening
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - lung diseases
KW - screening tests
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083085562&site=ehost-live&scope=site
UR - email: kenneth.lin@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 148
IS - 11
SP - 846
EP - 854
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083149585. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 52 ref. Subject Subsets: Public Health
N2 - Description: Updated U.S. Preventive Services Task Force (USPSTF) recommendation about screening for type 2 diabetes mellitus in adults. Methods: To estimate the balance of benefits and harms of screening, the USPSTF updated its 2003 evidence review, adding evidence from new trials as well as updates on earlier studies. The review for this current recommendation focused on evidence that early treatment prevented long-term adverse outcomes of diabetes, including cardiovascular events, visual impairment, renal failure, and amputation. Recommendations: Screen for type 2 diabetes in asymptomatic adults with sustained blood pressure (either treated or untreated) greater than 135/80 mm Hg. (B recommendation). Current evidence is insufficient to assess the balance of benefits and harms of routine screening in asymptomatic adults with blood pressure of 135/80 mm He or lower. (I statement).
KW - diabetes mellitus
KW - disease prevention
KW - guidelines
KW - human diseases
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - recommendations
KW - screening tests
KW - type 2 diabetes mellitus
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083149585&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for asymptomatic bacteriuria in adults: U.S. Preventive Services Task Force reaffirmation recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 1
SP - 43
EP - 47
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083172199. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 8 ref. Subject Subsets: Public Health
N2 - Description: Reaffirmation of the 2004 U.S. Preventive Services Task Force recommendation statement about screening for asymptomatic bacteriuria in adults. Methods: The U.S. Preventive Services Task Force did a targeted literature search for evidence on the benefits and harms of screening for asymptomatic bacteriuria in pregnant women, nonpregnant women, and men. Recommendations: Screen for asymptomatic bacteriuria with urine culture in pregnant women at 12 to 16 weeks' gestation or at the first prenatal visit, if later. (Grade A recommendation.) Do not screen for asymptomatic bacteriuria in men and nonpregnant women. (Grade D recommendation.).
KW - bacterial diseases
KW - guidelines
KW - human diseases
KW - men
KW - pregnancy
KW - screening
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - gestation
KW - recommendations
KW - screening tests
KW - United States of America
KW - urinary tract infection
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Reproduction and Development (VV060)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083172199&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 3
SP - 185
EP - 191
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083206712. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation statement about screening for prostate cancer. Methods: The USPSTF evaluated randomized, controlled trials of the benefits of prostate cancer screening; cohort and cross-sectional studies of the psychological harms of false-positive prostate-specific antigen test results; and evidence on the natural history of prostate-specific antigen-detected prostate cancer to address previously identified gaps in the evidence from the 2002 USPSTF recommendation. Recommendations: Current evidence is insufficient to assess the balance of benefits and harms of screening for prostate cancer in men younger than age 75 years (I statement). Do not screen for prostate cancer in men age 75 years or older (Grade D recommendation).
KW - disease prevention
KW - guidelines
KW - health services
KW - human diseases
KW - men
KW - neoplasms
KW - prostate
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - recommendations
KW - screening tests
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083206712&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the U.S. Preventive Services Task Force.
AU - Lin, K.
AU - Lipsitz, R.
AU - Miller, T.
AU - Janakiraman, S.
T2 - Annals of Internal Medicine
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 3
SP - 192
EP - 199
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Lin, K.: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20083206713. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - Background: Prostate cancer is the most common nonskin cancer in men in the United States, and prostate cancer screening has increased in recent years. In 2002, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening for prostate cancer with prostate-specific antigen (PSA) testing. Purpose: To examine new evidence on benefits and harms of screening asymptomatic men for prostate cancer with PSA. Data Sources: English-language articles identified in PubMed and the Cochrane Library (search dates, January 2002 to July 2007), reference lists of retrieved articles, and expert suggestions. Study Selection: Randomized, controlled trials and meta-analyses of PSA screening and cross-sectional and cohort studies of screening harms and of the natural history of screening-detected cancer were selected to answer the following questions: Does screening for prostate cancer with PSA, as a single-threshold test or as a function of multiple tests over time, decrease morbidity or mortality? What are the magnitude and nature of harms associated with prostate cancer screening, other than overtreatment? What is the natural history of PSA-detected, nonpalpable, localized prostate cancer? Data Extraction: Studies were reviewed, abstracted, and rated for quality by using predefined U.S. Preventive Services Task Force criteria. Data Synthesis: No good-quality randomized, controlled trials of screening for prostate cancer have been completed. In 1 cross-sectional and 2 prospective cohort studies of fair to good quality, false-positive PSA screening results caused psychological adverse effects for up to 1 year after the test. The natural history of PSA-detected prostate cancer is poorly understood. Limitations: Few eligible studies were identified. Long-term adverse effects of false-positive PSA screening test results are unknown. Conclusion: Prostate-specific antigen screening is associated with psychological harms, and its potential benefits remain uncertain.
KW - disease prevalence
KW - health services
KW - human diseases
KW - men
KW - neoplasm antigens
KW - neoplasms
KW - prostate
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - prostate-specific antigen
KW - screening tests
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083206713&site=ehost-live&scope=site
UR - email: kenneth.lin@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Behavioral counseling to prevent sexually transmitted infections: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 7
SP - 491
EP - 496
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083260583. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 11 ref. Subject Subsets: Public Health
N2 - Description: New U.S. Preventive Services Task Force (USPSTF) recommendations about behavioral counseling of adolescents and adults to prevent sexually transmitted infections (STIs). Methods: The USPSTF reviewed the evidence on the benefits and harms of counseling. The review included studies evaluating behavioral counseling interventions conducted in primary settings, those judged feasible in primary care, and those to which patients might be referred from primary care. Recommendations: The USPSTF recommends high-intensity behavioral counseling for all sexually active adolescents and for adults at increased risk for STIs. (B recommendation). Current evidence is insufficient to assess the balance of benefits and harms of behavioral counseling to prevent STIs in non-sexually active adolescents and in adults not at increased risk for STIs. (I statement).
KW - adolescents
KW - behaviour
KW - children
KW - counselling
KW - disease prevention
KW - human diseases
KW - reviews
KW - sexual behaviour
KW - sexually transmitted diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - counseling
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - STDs
KW - teenagers
KW - United States of America
KW - venereal diseases
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083260583&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Primary care interventions to promote breastfeeding: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 8
SP - 560
EP - 564
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083272627. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 11 ref. Subject Subsets: Dairy Science; Human Nutrition
N2 - Description: Update of a 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on counseling to promote breastfeeding. Methods: The USPSTF evaluated the results of a systematic review, conducted by the Tufts-New England Medical Center Evidence-based Practice Center, of literature published since January 2007 on primary care-initiated, -conducted, or -referable activities to promote and support breastfeeding. Recommendation: The USPSTF recommends interventions during pregnancy and after birth to promote and support breastfeeding (Grade B recommendation).
KW - breast feeding
KW - health programs
KW - health promotion
KW - infants
KW - primary health care
KW - reviews
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - United States of America
KW - Health Services (UU350)
KW - Human Nutrition (General) (VV100)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083272627&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008///
VL - 149
IS - 9
SP - 627
EP - 637
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20083286395. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for colorectal cancer. Methods: To update its recommendation, the USPSTF commissioned 2 studies: (1) a targeted systematic evidence review on 4 selected questions relating to test characteristics and benefits and harms of screening technologies, and (2) a decision analytic modeling analysis using population modeling techniques to compare the expected health outcomes and resource requirements of available screening modalities when used in a programmatic way over time. Recommendations: The USPSTF recommends screening for colorectal cancer using fecal occult blood testing, sigmoidoscopy, or colonoscopy in adults, beginning at age 50 years and continuing until age 75 years. The risks and benefits of these screening methods vary. (A recommendation) The USPSTF recommends against routine screening for colorectal cancer in adults 76 to 85 years of age. There may be considerations that support colorectal cancer screening in an individual patient. (C recommendation). The USPSTF recommends against screening for colorectal cancer in adults older than age 85 years. (D recommendation). The USPSTF concludes that the evidence is insufficient to assess the benefits and harms of computed tomographic colonography and fecal DNA testing as screening modalities for colorectal cancer. (I statement).
KW - adults
KW - colorectal cancer
KW - computed tomography
KW - disease prevention
KW - faeces
KW - guidelines
KW - human diseases
KW - neoplasms
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - colonoscopy
KW - feces
KW - recommendations
KW - screening tests
KW - sigmoidoscopy
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083286395&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Universal virus detection by degenerate-oligonucleotide primed polymerase chain reaction of purified viral nucleic acids.
AU - Nanda, S.
AU - Jayan, G.
AU - Voulgaropoulou, F.
AU - Sierra-Honigmann, A. M.
AU - Uhlenhaut, C.
AU - McWatters, B. J. P.
AU - Patel, A.
AU - Krause, P. R.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008///
VL - 152
IS - 1/2
SP - 18
EP - 24
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Nanda, S.: Center for Biologics Evaluation and Research, Food and Drug Administration, 29A/1C16, HFM-457, 29 Lincoln Drive, Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 20083231513. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 63231-63-0. Subject Subsets: Veterinary Science; Veterinary Science; Public Health
N2 - This study describes a novel non-specific universal virus detection method that permits molecular detection of viruses in biological materials containing mixtures of cells and viruses. Samples are subjected to nuclease digestion and ultracentrifugation to separate encapsidated viral nucleic acids from cellular nucleic acids. A degenerate oligonucleotide primer PCR (DOP-PCR) that has been optimized for the non-specific amplification of virus sized genomes is then employed. Virus identification is performed by sequencing of cloned DOP-PCR products followed by sequence comparison to sequences published in GenBank. This method was used to detect a variety of DNA viruses (including HSV, VZV, SV40, AAV, and EBV) and RNA viruses (including HTLV-I, HTLV-II, influenza, and poliovirus), which were spiked into cells, constitutively expressed in cell culture, or detected in productively infected cultured cells. This novel approach was compared with a non-specific virus detection method used previously and found to be several logs more sensitive. This type of approach has potential utility in solving virus detection and discovery problems where other methods have failed.
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - Herpes simplex viruses
KW - nucleic acids
KW - polymerase chain reaction
KW - RNA
KW - adeno-associated virus
KW - Deltaretrovirus
KW - Human herpesvirus 3
KW - Human herpesvirus 4
KW - Human T-cell lymphotropic virus
KW - Poliovirus
KW - Simian virus 40
KW - Parvoviridae
KW - ssDNA viruses
KW - DNA viruses
KW - viruses
KW - Herpesviridae
KW - dsDNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - Lymphocryptovirus
KW - Gammaherpesvirinae
KW - Deltaretrovirus
KW - Enterovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Polyomavirus
KW - Polyomaviridae
KW - simian polyomaviruses
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - HTLV-BLV group
KW - Influenza virus A and B
KW - PCR
KW - ribonucleic acid
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Diagnosis of Animal Diseases (LL886) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083231513&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01660934
UR - email: philip.krause@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature.
AU - Rabin, R. L.
AU - Levinson, A. I.
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
Y1 - 2008///
VL - 153
IS - 1
SP - 19
EP - 30
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0009-9104
AD - Rabin, R. L.: Office of Vaccines Regulation and Research, Center for Biologics Evaluation and Research, US Food and Drug Administration, 29 Lincoln Drive, Building 29, Room 203A, Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 20083227510. Publication Type: Journal Article. Language: English. Number of References: 128 ref. Subject Subsets: Public Health
N2 - There has been considerable interest in defining the relationship between the expression of allergic and autoimmune diseases in populations of patients. Are patients with autoimmune disease 'protected' from developing allergic (immunoglobulin E-mediated) diseases? Does the establishment of an atopic phenotype reduce the risk of the subsequent development of autoimmune diseases? Although there are clinical studies addressing this question, methodological problems, particularly in identification of atopic subjects, limits their usefulness. Moreover, an immune-based explanation of the observed epidemiological findings has relied on a paradigm that is currently undergoing increased scrutiny and modification to include newly defined effector cell subsets and the interaction between genetic and environmental factors, such as early endotoxin or mycobacterial exposure. To address this question, we reviewed a series of clinical reports that addressed coincidence or co-prevalence of atopy with four autoimmune diseases: psoriasis, rheumatoid arthritis, multiple sclerosis and type I diabetes mellitus. We present a model whereby active T helper type 1 (Th1) inflammation may suppress the development of atopy, and atopy may suppress the severity but not necessarily the onset of autoimmunity, and then discuss our model in the context of mechanisms of adaptive immunity with particular reference to the Th1/Th2 paradigms. Because the ultimate goal is to ameliorate or cure these diseases, our discussion may help to predict or interpret unexpected consequences of novel therapeutic agents used to target autoimmune or atopic diseases.
KW - allergies
KW - atopy
KW - autoimmune diseases
KW - autoimmunity
KW - diabetes mellitus
KW - human diseases
KW - inflammation
KW - multiple sclerosis
KW - psoriasis
KW - rheumatoid arthritis
KW - T lymphocytes
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - T cells
KW - type 1 diabetes mellitus
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083227510&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/cei
UR - email: rrabin@helix.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies.
AU - Wang, W.
AU - Butler, E. N.
AU - Veguilla, V.
AU - Vassell, R.
AU - Thomas, J. T.
AU - Moos, M., Jr.
AU - Ye, Z. P.
AU - Hancock, K.
AU - Weiss, C. D.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008///
VL - 153
IS - 2
SP - 111
EP - 119
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Wang, W.: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20083282584. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Public Health
N2 - Pseudotype reporter viruses provide a safe, quantitative, and high-throughput tool for assessing antibody neutralization for many viruses, including high pathogenicity H5 and H7 influenza A strains. However, adapting this system to other influenza subtypes has been hampered by variations in the protease cleavage site of hemagglutinin (HA) that make it less susceptible to the cleavage required for infectivity. In this report several proteases, reporter vectors, and cell substrates were evaluated while optimizing pseudovirus production, and robust methods were established for sensitive and specific neutralization of pseudotypes carrying influenza H1, H3, and H5 subtype HA that correlates well with titers obtained in microneutralization assays involving replicating influenza virus These findings should facilitate broad use of HA-pseudotypes that remove the need for infectious virus in a range of applications, including neutralization assays for serological surveys of viral infection and evaluations of vaccine sera.
KW - detection
KW - influenza viruses
KW - neutralizing antibodies
KW - strains
KW - viral haemagglutinins
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Influenzavirus
KW - viral hemagglutinins
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083282584&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01660934
UR - email: carol.weiss@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Defective rotavirus particle assembly in lovastatin-treated MA104 cells.
AU - Mohan, K. V.
AU - Muller, J.
AU - Atreya, C. D.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2008///
VL - 153
IS - 12
SP - 2283
EP - 2290
CY - Wien; Austria
PB - Springer-Verlag
SN - 0304-8608
AD - Mohan, K. V.: Laboratory of Hepatitis Viruses, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093013357. Publication Type: Journal Article. Language: English. Registry Number: 57-88-5. Subject Subsets: Public Health
N2 - Rotavirus is a non-enveloped virus that depends on cellular lipids for cell entry and associates with lipid rafts during assembly. However, the effects of cellular lipids on rotavirus assembly are still not fully understood. The present study analyzes the effects of lovastatin, an inhibitor of cholesterol biosynthesis, during rotavirus infection in MA104 cells with regard to viral growth and particle assembly. Following viral infection, a 2-log relative reduction of viral titers was observed in drug-treated cells, while viral mRNA levels in infected cells remained unaltered in both groups. Furthermore, the levels of some viral proteins in drug-treated cells were elevated. The observed discordance between the viral RNA and protein levels and the decrease in infectivity titers of viral progeny in the drug-treated cells suggested that the drug affects viral assembly, the viral proteins not being properly incorporated into virions. Transmission electron microscopic (TEM) analysis revealed that in drug-treated cells there was an increase in "empty-looking" rotavirus particles devoid of an electron-dense core as compared to the normal, electron-dense particles seen in untreated infected cells. The present study thus provides visual evidence of defective rotavirus particle assembly as a result of cholesterol depletion. The findings and conclusions in this article have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination policy.
KW - cholesterol
KW - culture media
KW - human diseases
KW - infectivity
KW - lipid metabolism
KW - lipids
KW - viral proteins
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - fat metabolism
KW - lipins
KW - lovastatin
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093013357&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/f137k71808p12468/?p=97298e9a43014f4f8c8c429b1db9ec0d&pi=11
UR - email: krishna.ketha@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Optical mapping and 454 sequencing of Escherichia coli O157:H7 isolates linked to the US 2006 spinach-associated outbreak.
AU - Kotewicz, M. L.
AU - Mammel, M. K.
AU - LeClerc, J. E.
AU - Cebula, T. A.
JO - Microbiology (Reading)
JF - Microbiology (Reading)
Y1 - 2008///
VL - 154
IS - 11
SP - 3518
EP - 3528
CY - Reading; UK
PB - Society for General Microbiology
SN - 1350-0872
AD - Kotewicz, M. L.: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20083282784. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Optical maps for five representative clinical, food-borne and bovine-derived isolates from the 2006 Escherichia coli O157:H7 outbreak linked to fresh spinach in the United States showed a common set of 14 distinct chromosomal markers that define the outbreak strain. Partial 454 DNA sequencing was used to characterize the optically mapped chromosomal markers. The markers included insertions, deletions, substitutions and a simple single nucleotide polymorphism creating a BamHI site. The Shiga toxin gene profile of the spinach-associated outbreak isolates (stx1-stx2+stx2c+) correlated with prophage insertions different from those in the prototypical EDL933 and Sakai reference strains (stx1+stx2+stx2c-). The prophage occupying the yehV chromosomal position in the spinach-associated outbreak isolates was similar to the stx1+ EDL933 cryptic prophage V, but it lacked the stx1 gene. In EDL933, the stx2 genes are within prophage BP933-W at the wrbA chromosomal locus; this locus was unoccupied in the spinach outbreak isolates. Instead, the stx2 genes were found within a chimeric BP933-W-like prophage with a different integrase, inserted at the argW locus in the outbreak isolates. An extra set of Shiga toxin genes, stx2c, was found in the outbreak isolates within a prophage integrated at the sbcB locus. The optical maps of two additional clinical isolates from the outbreak showed a single, different prophage variation in each, suggesting that changes occurred in the source strain during the course of this widespread, multi-state outbreak.
KW - bacterial diseases
KW - bacterial toxins
KW - chromosome analysis
KW - chromosome substitution
KW - deletions
KW - DNA sequencing
KW - food contamination
KW - genes
KW - human diseases
KW - mapping
KW - microbial contamination
KW - outbreaks
KW - single nucleotide polymorphism
KW - spinach
KW - transposable elements
KW - Maryland
KW - USA
KW - Escherichia coli
KW - man
KW - Spinacia oleracea
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - cartography
KW - DNA insertion elements
KW - E. coli
KW - food contaminants
KW - insertion elements
KW - insertion sequences
KW - mobile genetic elements
KW - mobile sequences
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - transposons
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083282784&site=ehost-live&scope=site
UR - http://mic.sgmjournals.org
UR - email: thomas.cebula@FDA.HHS.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - High levels of physical inactivity and sedentary behaviors among us immigrant children and adolescents.
AU - Singh, G. K.
AU - Yu, S. M.
AU - Siahpush, M.
AU - Kogan, M. D.
T2 - Archives of Pediatrics & Adolescent Medicine
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
Y1 - 2008///
VL - 162
IS - 8
SP - 756
EP - 763
CY - Chicago; USA
PB - American Medical Association
SN - 1072-4710
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Ln, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20083206898. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Leisure, Recreation, Tourism; Public Health
N2 - Objective: To examine the prevalence and correlates of physical inactivity and sedentary behavior among immigrant and US-born children. Design: Cross-sectional analysis using data from the 2003 National Survey of Children's Health, a telephone survey conducted between January 29, 2003, and July 1, 2004. Setting: United States. Participants: Multivariate logistic and least squares regression models were used to analyze immigrant differentials among 68 288 children aged 6 through 17 years. Main Exposure: Ethnic-immigrant status. Main Outcome Measures: Prevalence and odds of regular physical activity, inactivity, television watching, and lack of sports participation. Results: Physical inactivity and sedentary behaviors varied widely among children in various ethnic-immigrant groups. For example, 22.5% of immigrant Hispanic children were physically inactive compared with 9.5% of US-born white children with US-born parents. Approximately 67% of immigrant Hispanic children did not participate in sports compared with 30.2% of native Asian children. Overall, immigrant children were significantly more likely to be physically inactive and less likely to participate in sports than native children; they were, however, less likely to watch television 3 or more hours per day than native children, although the nativity gap narrowed with increasing acculturation levels. Compared with native white children, the adjusted odds of physical inactivity and lack of sports participation were both 2 times higher for immigrant Hispanic children with foreign-born parents, and the odds of television watching were 1.5 and 2.3 times higher for native Hispanic and black children, respectively. Conclusions: Immigrant children in each ethnic minority group generally had higher physical inactivity and lower sports participation levels than native children. To reduce disparities, health education programs need to promote physical activity among children in immigrant families.
KW - acculturation
KW - adolescents
KW - Asians
KW - blacks
KW - children
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - immigrants
KW - minorities
KW - physical activity
KW - sport
KW - television
KW - whites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Sport and Recreational Activities (UU625) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083206898&site=ehost-live&scope=site
UR - http://www.archpediatrics.com
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Tuberculosis studies in Muscogee County, Georgia. I. Community-wide tuberculosis research.
AU - Comstock, G. W.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2008///
VL - 168
IS - 7
SP - 687
EP - 691
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Comstock, G. W.: Field Studies Branch, Division of Tuberculosis, Public Health Service, USA.
N1 - Accession Number: 20083304499. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - tuberculosis
KW - Georgia
KW - USA
KW - Mycobacterium tuberculosis
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - bacterium
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083304499&site=ehost-live&scope=site
UR - http://aje.oxfordjournals.org/cgi/reprint/168/7/687
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - U.S. military service members' perceptions of the anthrax vaccine immunization program.
AU - Pica-Branco, D.
AU - Hudak, R. P.
JO - Military Medicine
JF - Military Medicine
Y1 - 2008///
VL - 173
IS - 5
SP - 429
EP - 433
CY - Bethesda; USA
PB - Association of Military Surgeons of the US
SN - 0026-4075
AD - Pica-Branco, D.: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pediatric and Maternal Health, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20083199714. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The perceptions of the U.S. military service members regarding the Department of Defense Anthrax Vaccine Immunization Program (AVIP) were investigated in October 2004. Randomly selected active duty service members from the uniformed services assigned to a Caribbean military base who participated in the AVIP during 1998-2000 were surveyed. Their perceptions regarding ethics, effectiveness and safety of the programme were determined using a 14-item Likert scale questionnaire. The results showed that a substantial number of service members disagreed with issues regarding the ethics, safety and efficacy of the AVIP. Enhanced training and education are recommended to increase the understanding of the benefits of the AVIP.
KW - anthrax
KW - attitudes
KW - bacterial diseases
KW - ethics
KW - health programs
KW - human diseases
KW - immunization
KW - immunization programmes
KW - military personnel
KW - safety
KW - vaccination
KW - USA
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - immunization programs
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083199714&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/amsus/zmm/2008/00000173/00000005/art00016
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
AU - Xia QingSu
AU - Yan Jian
AU - Chou, M. W.
AU - Fu, P. P.
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2008///
VL - 178
IS - 2
SP - 77
EP - 82
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0378-4274
AD - Xia QingSu: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083199389. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Pyrrolizidine alkaloid-containing plants are widespread in the world and may be the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolism to exert their genotoxicity and tumorigenicity. Our mechanistic studies have determined that metabolism of the retronecine-type (riddelliine, retrorsine, and monocrotaline), heliotridine-type (lasiocarpine), and otonecine-type (clivorine) tumorigenic pyrrolizidine alkaloids in vivo and/or in vitro all generates a common set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts responsible for tumor induction. All the pyrrolizidine alkaloids studied previously are diesters with an ester linkage at the C7 and C9 positions of the necine base. In this study, we report that F344 rat liver microsomal metabolism of heliotrine, a tumorigenic monoester bearing a hydroxyl group at the C7 of the necine base, resulted in the formation of the dehydroheliotridine (DHH) metabolite. When incubations of heliotrine were carried out in the presence of calf thymus DNA, the same set of DHP-derived DNA adducts was formed. These results support that DHP-derived DNA adducts are potential common biomarkers of pyrrolizidine alkaloid exposure and tumorigenicity. For comparison, the dehydroretronecine (DHR)-derived DNA adducts formed from metabolism of riddleiine, retrorsine, monocrotaline, riddelleiine N-oxide, and retrorsine N-oxide were measured in parallel; the levels of DHP-derived DNA adduct formation were in the order: riddelliine ~ retrorsine > monocrotaline > retrorsine N-oxide ≥ riddelliine N-oxide > heliotrine.
KW - adverse effects
KW - chemical composition
KW - genotoxicity
KW - pyrrolizidine alkaloids
KW - adverse reactions
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083199389&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-4S03RFN-1&_user=6686535&_coverDate=05%2F05%2F2008&_rdoc=3&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235177%232008%23998219997%23687657%23FLA%23display%23Volume)&_cdi=5177&_sort=d&_docanchor=&_ct=11&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=16c683158bb1518831f4bf0fcf10c073
UR - email: peter.fu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways.
AU - Xu, L. X.
AU - Fang, H.
AU - Frucht, D. M.
T2 - Journal of Immunology
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2008///
VL - 180
IS - 6
SP - 4139
EP - 4147
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Xu, L. X.: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083077447. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Veterinary Science; Veterinary Science
N2 - The combination of lethal factor and its receptor-binding partner, protective Ag, is termed lethal toxin (LT) and has critical pathogenic activity during infection with Bacillus anthracis. We herein report that anthrax LT binds and enters murine neutrophils, leading to the cleavage of mitogen-activated protein kinase kinase/MEK/MAPKK 1-4 and 6, but not mitogen-activated protein kinase kinase 5 and 7. Anthrax LT treatment of neutrophils disrupts signaling to downstream MAPK targets in response to TLR stimulation. Following anthrax LT treatment, ERK family and p38 phosphorylation are nearly completely blocked, but signaling to JNK family members persists in vitro and ex vivo. In contrast to previous reports involving human neutrophils, anthrax LT treatment of murine neutrophils increases their production of superoxide in response to PMA or TLR stimulation in vitro or ex vivo. Although this enhanced superoxide production correlates with effects due to the LT-induced blockade of ERK signaling, it requires JNK signaling that remains largely intact despite the activity of anthrax LT. These findings reveal a previously unrecognized mechanism through which anthrax LT supports a critical proinflammatory response of murine neutrophils.
KW - animal models
KW - bacterial toxins
KW - laboratory animals
KW - neutrophils
KW - signal transduction
KW - Bacillus anthracis
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083077447&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: david.frucht@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism.
AU - Warfel, J. M.
AU - D'Agnillo, F.
T2 - Journal of Immunology
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2008///
VL - 180
IS - 11
SP - 7516
EP - 7524
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Warfel, J. M.: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29, Bethesda, MD 20892, USA.
N1 - Accession Number: 20083163071. Publication Type: Journal Article. Language: English. Number of References: 67 ref. Registry Number: 308079-78-9. Subject Subsets: Public Health
N2 - Impaired host defenses and vascular dysfunction are hallmarks of the late, antibiotic-refractory stages of systemic anthrax infection. Anthrax lethal toxin (LT), a key virulence factor of Bacillus anthracis, was previously shown to enhance VCAM-1 expression on primary human endothelial cells suggesting a causative link between dysregulated adhesion molecule expression and the poor immune response and vasculitis associated with anthrax. In this study, we report that LT amplification of TNF-induced VCAM-1 expression is driven transcriptionally by the cooperative activation of NF-κB and IFN regulatory factor-1 (IRF-1). LT enhancement of NF-κB phosphorylation and nuclear translocation correlated temporally with a delayed reaccumulation of IκBα, while increased induction of IRF-1 was linked to STAT1 activation. LT failed to augment TNF-induced ICAM-1 or E-selectin expression, two adhesion molecules regulated by NF-κB, but not IRF-1. These results suggest that LT can differentially modulate NF-κB target genes and highlight the importance of IRF-1 in VCAM-1 enhancement. Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which LT contributes to anthrax pathogenesis.
KW - anthrax
KW - bacterial toxins
KW - genes
KW - human diseases
KW - immune response
KW - pathogenesis
KW - phosphorylation
KW - tumour necrosis factor
KW - virulence
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - cachectin
KW - cachexin
KW - immunity reactions
KW - immunological reactions
KW - tumor necrosis factor
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083163071&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: felice.dagnillo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
AU - Mukherjee, A.
AU - Mammel, M. K.
AU - LeClerc, J. E.
AU - Cebula, T. A.
T2 - Journal of Bacteriology
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008///
VL - 190
IS - 5
SP - 1710
EP - 1717
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0021-9193
AD - Mukherjee, A.: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, US FDA (HFS-25), 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083077691. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Registry Number: 7535-00-4. Subject Subsets: Soyabeans; Human Nutrition; Horticultural Science
N2 - In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete coding sequences for enzyme IIA (EIIA)Aga/Gam, EIIBAga, EIICAga, and EIIDAga of the Aga PTS are present, E. coli O157:H7 strains normally are able to utilize Aga as a sole carbon source. The Gam PTS complex, in contrast, lacks EIICGam, and consequently, E. coli O157:H7 strains cannot utilize Gam. Phenotypic analyses of 120 independent isolates of E. coli O157:H7 from our culture collection revealed that the overwhelming majority (118/120) displayed the expected Aga+ Gam- phenotype. Yet, when 194 individual isolates, derived from a 2006 spinach-associated E. coli O157:H7 outbreak, were analyzed, all (194/194) displayed an Aga- Gam- phenotype. Comparison of aga/gam sequences from two spinach isolates with those of EDL933 and Sakai revealed a single nucleotide change (G:C->A:T) in the agaF gene in the spinach-associated isolates. The base substitution in agaF, which encodes EIIAAga/Gam of the PTS, changes a conserved glycine residue to serine (Gly91Ser). Pyrosequencing of this region showed that all spinach-associated E. coli O157:H7 isolates harbored this same G:C->A:T substitution. Notably, when agaF+ was cloned into an expression vector and transformed into six spinach isolates, all (6/6) were able to grow on Aga, thus demonstrating that the Gly91Ser substitution underlies the Aga- phenotype in these isolates.
KW - disease prevalence
KW - epidemiology
KW - food contamination
KW - food hygiene
KW - food poisoning
KW - food safety
KW - galactosamine
KW - gene expression
KW - genes
KW - microbial contamination
KW - nucleotide sequences
KW - outbreaks
KW - phenotypes
KW - poisoning
KW - spinach
KW - toxicity
KW - USA
KW - Escherichia coli
KW - Spinacia oleracea
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - DNA sequences
KW - E. coli
KW - food contaminants
KW - toxicosis
KW - United States of America
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083077691&site=ehost-live&scope=site
UR - http://jb.asm.org/
UR - email: Thomas.Cebula@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An economic analysis of the universal varicella vaccination program in the United States.
AU - Zhou, F. J.
AU - Ortega-Sanchez, I. R.
AU - Guris, D.
AU - Shefer, A.
AU - Lieu, T.
AU - Seward, J. F.
T3 - Special Issue: Varicella vaccine in the United States: a decade of prevention and the way forward.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008///
VL - 197
IS - Suppl. 2
SP - S156
EP - S164
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Zhou, F. J.: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Rd. NE, MS E-52, Atlanta, GA 30333, USA.
N1 - Accession Number: 20083268884. Publication Type: Journal Article. Note: Special Issue: Varicella vaccine in the United States: a decade of prevention and the way forward. Language: English. Subject Subsets: Public Health
N2 - Frequent varicella outbreaks with sizable impact on the US public health system have continued to occur despite the success of the country's 1-dose varicella vaccination program. The Advisory Committee on Immunization Practices recently recommended adding a routine second dose of varicella vaccine and weighed economic projections as well as public health goals in their deliberations. This decision-tree-based analysis was conducted to evaluate the economic impact of the projected 2-dose varicella vaccination program as well as the existing 1-dose program. The analysis used population-based vaccination coverage and disease incidence data to make projections for a hypothetical US birth cohort of 4,100,000 infants born in 2006. Compared with no vaccination, both the 1-dose program (societal benefit-cost ratio [BCR], 4.37) and 2-dose program (BCR, 2.73) were estimated to be cost saving from the societal perspective. Compared with the 1-dose program, the incremental second dose was not cost saving (societal incremental BCR, 0.56). The incremental cost-effectiveness ratio for the second dose was $343 per case prevented, or ~$109,000 per quality-adjusted life-year saved, and these results were sensitive to assumptions about vaccine effectiveness and prices.
KW - cost analysis
KW - costs
KW - disease prevention
KW - dosage
KW - economic analysis
KW - human diseases
KW - immunization
KW - immunization programmes
KW - infants
KW - vaccination
KW - vaccines
KW - varicella
KW - USA
KW - Human herpesvirus 3
KW - man
KW - Herpesviridae
KW - dsDNA viruses
KW - DNA viruses
KW - Varicellovirus
KW - Alphaherpesvirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chicken pox
KW - costing
KW - costings
KW - immune sensitization
KW - immunization programs
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083268884&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/522135
UR - email: faz1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The membrane form of tumor necrosis factor is sufficient to mediate partial innate immunity to Francisella tularensis live vaccine strain.
AU - Cowley, S. C.
AU - Goldberg, M. F.
AU - Ho, J. A.
AU - Elkins, K. L.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008///
VL - 198
IS - 2
SP - 284
EP - 292
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Cowley, S. C.: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA.
N1 - Accession Number: 20083269009. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 308079-78-9. Subject Subsets: Medical & Veterinary Entomology; Agricultural Biotechnology
N2 - Here we characterize Francisella tularensis live vaccine strain (LVS) infection in total tumor necrosis factor (TNF) knockout (KO) mice and in transgenic mice expressing only the membrane form of TNF (memTNF). MemTNF mice, but not TNF KO mice, survived low-dose, sublethal LVS infections. Splenic nitric oxide production was impaired in infected memTNF mice and was absent in infected TNF KO mice. Spleen cell production of interferon-γ, RANTES, and monocyte chemotactic protein-1 was elevated in TNF KO mice, compared with that in WT mice, by days 4-5 after infection, along with transiently increased numbers of CCR2+ cells, whereas memTNF mice had an intermediate phenotype. By day 6 after infection, TNF KO mice, but not memTNF mice, exhibited massive apoptosis in spleens and livers, which shortly preceded their death. Thus, memTNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice.
KW - animal models
KW - disease models
KW - immunity
KW - laboratory animals
KW - tumour necrosis factor
KW - Francisella tularensis
KW - mice
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - cachectin
KW - cachexin
KW - tumor necrosis factor
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083269009&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/589620
UR - email: siobhan.cowley@fda.hhs.gov\karen.elkins@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralizes a heterologous wild-type mumps virus associated with a large outbreak.
AU - Rubin, S. A.
AU - Qi, L.
AU - Audet, S. A.
AU - Sullivan, B.
AU - Carbone, K. M.
AU - Bellini, W. J.
AU - Rota, P. A.
AU - Sirota, L.
AU - Beeler, J.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008///
VL - 198
IS - 4
SP - 508
EP - 515
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Rubin, S. A.: Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bldg. 29A, Rm. 1A-21, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093062008. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A vaccine strains used in the countries affected by the outbreaks. This finding suggests that genotype A vaccine strains could have reduced efficacy against heterologous mumps viruses. The remote history of vaccination also suggests that waning immunity could have contributed to susceptibility. To examine these issues, we obtained consecutive serum samples from children at different intervals after vaccination and assayed the ability of these samples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type virus obtained during the mumps outbreak that occurred in the United States in 2006. Although the geometric mean neutralizing antibody titers against the genotype G virus were approximately one-half the titers measured against the vaccine strain, and although titers to both viruses decreased with time after vaccination, antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralized the outbreak-associated virus at all time points tested.
KW - children
KW - human diseases
KW - immunization
KW - mumps
KW - neutralizing antibodies
KW - outbreaks
KW - vaccination
KW - vaccines
KW - man
KW - Mumps virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093062008&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/abs/10.1086/590115
UR - email: steven.rubin@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infection.
AU - Rios, M.
AU - Daniel, S.
AU - Dayton, A. I.
AU - Wood, O.
AU - Hewlett, I. K.
AU - Epstein, J. S.
AU - Caglioti, S.
AU - Stramer, S. L.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008///
VL - 198
IS - 9
SP - 1300
EP - 1308
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Rios, M.: Laboratory of Molecular Virology-Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20093062086. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious. Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs). Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody-positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious. Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation.
KW - antibodies
KW - blood transfusion
KW - disease transmission
KW - human diseases
KW - infectivity
KW - macrophages
KW - viraemia
KW - West Nile fever
KW - man
KW - West Nile virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - viremia
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093062086&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/592277
UR - email: Maria.Rios@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - FDA toxicity databases and real-time data entry.
AU - Arvidson, K. B.
A2 - Keshava, N.
A2 - Roszell, L.
A2 - Fowler, B.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2008///
VL - 233
IS - 1
SP - 17
EP - 19
CY - Orlando; USA
PB - Elsevier Inc
SN - 0041-008X
AD - Arvidson, K. B.: Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA.
N1 - Accession Number: 20083328744. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition
N2 - Structure-searchable electronic databases are valuable new tools that are assisting the FDA in its mission to promptly and efficiently review incoming submissions for regulatory approval of new food additives and food contact substances. The Center for Food Safety and Applied Nutrition's Office of Food Additive Safety (CFSAN/OFAS), in collaboration with Leadscope, Inc., is consolidating genetic toxicity data submitted in food additive petitions from the 1960s to the present day. The Center for Drug Evaluation and Research, Office of Pharmaceutical Science's Informatics and Computational Safety Analysis Staff (CDER/OPS/ICSAS) is separately gathering similar information from their submissions. Presently, these data are distributed in various locations such as paper files, microfiche, and non-standardized toxicology memoranda. The organization of the data into a consistent, searchable format will reduce paperwork, expedite the toxicology review process, and provide valuable information to industry that is currently available only to the FDA. Furthermore, by combining chemical structures with genetic toxicity information, biologically active moieties can be identified and used to develop quantitative structure-activity relationship (QSAR) modeling and testing guidelines. Additionally, chemicals devoid of toxicity data can be compared to known structures, allowing for improved safety review through the identification and analysis of structural analogs. Four database frameworks have been created: bacterial mutagenesis, in vitro chromosome aberration, in vitro mammalian mutagenesis, and in vivo micronucleus. Controlled vocabularies for these databases have been established. The four separate genetic toxicity databases are compiled into a single, structurally-searchable database for easy accessibility of the toxicity information. Beyond the genetic toxicity databases described here, additional databases for subchronic, chronic, and teratogenicity studies have been prepared.
KW - chemical structure
KW - chromosome aberrations
KW - data processing
KW - databases
KW - food additives
KW - food safety
KW - genotoxicity
KW - in vitro
KW - information
KW - mutagenesis
KW - public agencies
KW - structure activity relationships
KW - teratogenesis
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - chromosome abnormalities
KW - data banks
KW - government agencies
KW - micronucleus
KW - United States Food and Drug Administration
KW - United States of America
KW - Information and Documentation (CC300)
KW - Agencies and Organizations (DD100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083328744&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4SWN0KF-4&_user=6686535&_coverDate=11%2F15%2F2008&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%237159%232008%23997669998%23701930%23FLA%23display%23Volume)&_cdi=7159&_sort=d&_docanchor=&_ct=28&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=8428fb36cc2ad892981d80ae185c739a
UR - email: kirk.arvidson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatitis B in a high prevalence New Zealand population: a mathematical model applied to infection control policy.
AU - Thornley, S.
AU - Bullen, C.
AU - Roberts, M.
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
Y1 - 2008///
VL - 254
IS - 3
SP - 599
EP - 603
CY - London; UK
PB - Elsevier Ltd
SN - 0022-5193
AD - Thornley, S.: Auckland Regional Public Health Service, Cornwall Complex, Floor 2, Building 15, Greenlane Clinical Centre, Private Bag 92605, Symonds Street, Auckland 1150, New Zealand.
N1 - Accession Number: 20083271416. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Background: Chronic hepatitis B (CHB) is a vaccine preventable disease of global public health importance. The prevalence of CHB in New Zealand's Tongan population is over 10%, a level consistent with endemic infection, which contrasts to the low overall New Zealand prevalence (<0.5%). Despite the introduction of infant vaccination in 1988, coverage among Tongan children is estimated to be only 53%. Aims: To estimate the population benefit of additional public health control measures besides 'business as usual' infant vaccination for hepatitis B in high prevalence populations. Methods: A mathematical model of hepatitis B virus (HBV) transmission was used to predict future CHB prevalence in the New Zealand Tongan population under different infection control strategies. Results: Prevalence of CHB is predicted to plateau at 2% in the New Zealand Tongan population if coverage remains at current levels, which are therefore insufficient to achieve long-term elimination of HBV. The critical proportion of immunisation coverage for elimination of the virus is estimated to be 73%. The effect of screening for HBV carriage and early disease management was unable to be quantified, but is likely to reduce the population burden of HBV infection and thus contribute to accelerating elimination. Conclusions and recommendations: Mathematical models are a useful tool to forecast the future burden of CHB under a range of control strategy scenarios in high prevalence populations. Serosurveillance and targeted vaccination has similarly arrested HBV transmission in time-series prevalence studies from Taiwan and Alaska. Such a policy may demonstrate similar efficacy in New Zealand ethnic groups with endemic HBV infection.
KW - control programmes
KW - disease control
KW - disease prevalence
KW - disease surveys
KW - disease transmission
KW - epidemiology
KW - hepatitis B
KW - human diseases
KW - infants
KW - mathematical models
KW - vaccination
KW - New Zealand
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - control programs
KW - disease surveillance
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083271416&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WMD-4SWN0X1-1&_user=6686535&_coverDate=10%2F07%2F2008&_rdoc=14&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236932%232008%23997459996%23697899%23FLA%23display%23Volume)&_cdi=6932&_sort=d&_docanchor=&_ct=28&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=1753023aec144b86a16258711aefee82
UR - email: sithor@woosh.co.nz
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Compton suppression spectrometry for analysis of short-lived neutron activation products in foods.
AU - Anderson, D. L.
AU - Cunningham, W. C.
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
Y1 - 2008///
VL - 276
IS - 1
SP - 23
EP - 28
CY - Dordrecht; Netherlands
PB - Springer Science + Business Media
SN - 0236-5731
AD - Anderson, D. L.: Elemental Research Branch (HFS-338), U. S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083166376. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 7553-56-2, 7775-09-9. Subject Subsets: Human Nutrition
N2 - Compton suppression spectrometry was used to analyze foods for elements with short-lived neutron activation products (half-lives of about 2 minutes to 1.5 days). Analysis conditions were optimized to provide quality assurance analyses for iodine in FDA's Total Diet Study. Iodine mass fractions (0.075 to 2.03 mg/kg) were measured in 19 of 42 foods analyzed, with limits of detection (LODs) ranging from 0.03 to 1.4 mg/kg, mostly depending on NaCl content. LODs were lowered by up to a factor of 2 for 16 elements. Suppression factors ranged from about 2 to 8 over the energy range 400 to 3200 keV.
KW - analytical methods
KW - food composition
KW - iodine
KW - sodium chlorate
KW - spectrometry
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083166376&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/n48qk23q54120702/?p=1d0b94780d2843ac90fe30e4fc6bdb64&pi=3
UR - email: david.anderson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum.
AU - Mahajan, B.
AU - Selvapandiyan, A.
AU - Gerald, N. J.
AU - Majam, V.
AU - Zheng, H.
AU - Wickramarachchi, T.
AU - Tiwari, J.
AU - Fujioka, H.
AU - Moch, J. K.
AU - Kumar, N.
AU - Aravind, L.
AU - Nakhasi, H. L.
AU - Kumar, S.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008///
VL - 283
IS - 46
SP - 31871
EP - 31883
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Mahajan, B.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-313), Rockville, MD 20852, USA.
N1 - Accession Number: 20083318054. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Protozoology; Agricultural Biotechnology
N2 - Molecules and cellular mechanisms that regulate the process of cell division in malaria parasites remain poorly understood. In this study we isolate and characterize the four Plasmodium falciparum centrins (PfCENs) and, by growth complementation studies, provide evidence for their involvement in cell division. Centrins are cytoskeleton proteins with key roles in cell division, including centrosome duplication, and possess four Ca2+-binding EF hand domains. By means of phylogenetic analysis, we were able to decipher the evolutionary history of centrins in eukaryotes with particular emphasis on the situation in apicomplexans and other alveolates. Plasmodium possesses orthologs of four distinct centrin paralogs traceable to the ancestral alveolate, including two that are unique to alveolates. By real time PCR and/or immunofluorescence, we determined the expression of PfCEN mRNA or protein in sporozoites, asexual blood forms, gametocytes, and in the oocysts developing inside mosquito mid-gut. Immunoelectron microscopy studies showed that centrin is expressed in close proximity with the nucleus of sporozoites and asexual schizonts. Furthermore, confocal and widefield microscopy using the double staining with α-tubulin and centrin antibodies strongly suggested that centrin is associated with the parasite centrosome. Following the episomal expression of the four PfCENs in a centrin knock-out Leishmania donovani parasite line that exhibited a severe growth defect, one of the PfCENs was able to partially restore Leishmania growth rate and overcome the defect in cytokinesis in such mutant cell line. To our knowledge, this study is the first characterization of a Plasmodium molecule that is involved in the process of cell division. These results provide the opportunity to further explore the role of centrins in cell division in malaria parasites and suggest novel targets to construct genetically modified, live attenuated malaria vaccines.
KW - bloodstream forms
KW - cell cycle
KW - cell division
KW - centrosomes
KW - cytoskeleton
KW - developmental stages
KW - evolution
KW - gametocytes
KW - gene expression
KW - genes
KW - growth rate
KW - messenger RNA
KW - oocysts
KW - phylogeny
KW - proteins
KW - schizonts
KW - sporozoites
KW - Leishmania donovani
KW - Plasmodium falciparum
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - centrins
KW - cytokinesis
KW - growth phase
KW - karyokinesis
KW - mRNA
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Microbial Life Cycles (ZZ396) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083318054&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of tetramethylene disulfotetramine in foods using solid-phase microextraction-gas chromatography-mass spectrometry.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2008///
VL - 1192
IS - 1
SP - 36
EP - 40
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Jager, L. S. de: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland, USA.
N1 - Accession Number: 20083134772. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition
N2 - An automated solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) method for the determination of tetramethylene disulfotetramine in foods was developed. A comparison of direct immersion (DI) and headspace (HS) extraction techniques using a 70 µm carbowax/divinylbenzene (CW/DVB) fiber is presented. The optimized DI-SPME method provided an aqueous extraction limit of detection (LOD) of 9.0 ng/g while the HS-SPME LOD was 2.7 ng/g. In both SPME modes, recovery was highly matrix dependent and quantification requires standard addition calibrations. Analysis of foods using DI-SPME encountered many obstacles including fiber fouling, low recovery and poor reproducibility. HS-SPME was successfully applied to food analysis with minimal interferences. Standard addition calibration curves for foods gave high linearity (R2>0.98), reproducibility (RSD<12%) and sensitivity with LODs ranging from 0.9 to 4.3 ng/g.
KW - analytical methods
KW - determination
KW - extraction
KW - food analysis
KW - foods
KW - gas chromatography
KW - mass spectrometry
KW - polyamines
KW - techniques
KW - toxic substances
KW - analytical techniques
KW - poisons
KW - solid phase microextraction
KW - tetramethylenedisulfotetramine
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083134772&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4S39MNV-8&_user=6686535&_coverDate=05%2F23%2F2008&_rdoc=6&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235248%232008%23988079998%23687629%23FLA%23display%23Volume)&_cdi=5248&_sort=d&_docanchor=&_ct=28&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=4d6ddba1bb1773a414fc4d57cd8a8251
UR - email: lowri.dejager@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of iodide and thiocyanate in powdered milk and infant formula by on-line enrichment ion chromatography with photodiode array detection.
AU - Niemann, R. A.
AU - Anderson, D. L.
JO - Journal of Chromatography, A
JF - Journal of Chromatography, A
Y1 - 2008///
VL - 1200
IS - 2
SP - 193
EP - 197
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V. Physical Sciences and Engineering Division
SN - 0021-9673
AD - Niemann, R. A.: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083220238. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 20461-54-5. Subject Subsets: Dairy Science; Soyabeans
N2 - Thiocyanate ranks after perchlorate as a potent inhibitor of iodide uptake by the thyroid but may be more concentrated in some food items such as milk products as to supersede perchlorate as the goitrogen of concern. A column-switching anion-exchange chromatographic method with UV spectral detection was developed to measure and confirm iodide and thiocyanate in powders of dry milk and infant formula. An aqueous solution was subjected to centrifugal ultrafiltration, the ultrafiltrate was cleaned up on a carbon solid-phase extraction column, and an aliquot was transferred to a precolumn for enrichment and subsequent injection onto an analytical column. In infant formula samples, thiocyanate was found at 2.0-5.1 mg/kg in five of seven milk-based products and was not found in the other two nor in three soy-based products tested (0.2 mg/kg LOQ); iodide was found at 0.3-1.3 mg/kg (0.04 mg/kg LOQ). In 13 dry milk samples, thiocyanate was found at 27-38 mg/kg (1 mg/kg LOQ), and iodide was found at 1.8-3.2 mg/kg (0.2 mg/kg LOQ).
KW - analytical methods
KW - chromatography
KW - contaminants
KW - contamination
KW - detection
KW - determination
KW - dried milk
KW - food safety
KW - infant formulae
KW - iodide
KW - milk composition
KW - techniques
KW - thiocyanates
KW - analytical techniques
KW - infant formula
KW - infant formulas
KW - milk constituents
KW - milk powder
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083220238&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4SM62GT-B&_user=6686535&_coverDate=07%2F25%2F2008&_rdoc=13&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235248%232008%23987999997%23693603%23FLA%23display%23Volume)&_cdi=5248&_sort=d&_docanchor=&_ct=24&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=0b05352bba67095574960f241c5d7d2b
UR - email: richard.niemann@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.
AU - Pogribny, I. P.
AU - Karpf, A. R.
AU - James, S. R.
AU - Melnyk, S.
AU - Han, T.
AU - Tryndyak, V. P.
A2 - Williams, C.
T3 - Special issue: Brains, genes and nutrition.
JO - Brain Research
JF - Brain Research
Y1 - 2008///
VL - 1237
SP - 25
EP - 34
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V, Biomedical Division
SN - 0006-8993
AD - Pogribny, I. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083312559. Publication Type: Journal Article. Note: Special issue: Brains, genes and nutrition. Language: English. Number of References: 42 ref. Registry Number: 62-49-7, 59-30-3, 63-68-3. Subject Subsets: Human Nutrition
N2 - The maintenance of the cellular epigenomic landscape, which depends on the status of the one-carbon metabolic pathway, is essential for normal central nervous system development and function. In the present study, we examined the epigenetic alterations in the brains of Fisher 344 rats induced by the long-term administration of a diet lacking of essential one-carbon nutrients, methionine, choline, and folic acid. The results demonstrated that feeding a folate/methyl-deficient diet causes global DNA hypermethylation as indicated by an increase of genomic 5-methyl-2′-deoxycytidine (5mdC) content and more importantly, by an increase of methylation within unmethylated CpG-rich DNA domains. Interestingly, these epigenetic changes were opposite to those observed in the livers of the same folate/methyl-deficient rats. The hypermethylation changes were associated with an increased protein expression of de novo DNA methyltransferase DNMT3a and methyl-CpG-binding protein 2. Additionally, the gene expression profiling identified 33 significantly up- or down-regulated genes (fold change ≥1.5 and p≤0.05) in the brains of rats fed a folate/methyl-deficient diet for 36 weeks. Interestingly, we detected an up-regulation of regulatory factor X, 3 (Rfx3) gene, a sequence-specific DNA-binding protein, that mediates the transcriptional activation of silenced by methylation genes, which may be an adaptive protective brain response to hypermethylation. Together, these data suggest that the proper maintenance of the epigenomic landscape in normal brain depends on the adequate supply of essential nutrients involved in the metabolism of methyl groups.
KW - animal models
KW - brain
KW - choline
KW - diet
KW - epigenetics
KW - folic acid
KW - gene expression profiling
KW - genomes
KW - laboratory animals
KW - methionine
KW - molecular biology
KW - molecular genetics
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochemical genetics
KW - cerebrum
KW - folacin
KW - folate
KW - Animal Models of Human Nutrition (VV140)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083312559&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4T3M6B4-5&_user=6686535&_coverDate=10%2F27%2F2008&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234841%232008%23987629999%23699096%23FLA%23display%23Volume)&_cdi=4841&_sort=d&_docanchor=&_ct=22&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=f760643d7ee536f4ec88d6fcf168404c
UR - email: igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet.
AU - Bagnyukova, T. V.
AU - Powell, C. L.
AU - Pavliv, O.
AU - Tryndyak, V. P.
AU - Pogribny, I. P.
A2 - Williams, C.
T3 - Special issue: Brains, genes and nutrition.
JO - Brain Research
JF - Brain Research
Y1 - 2008///
VL - 1237
SP - 44
EP - 51
CY - Amsterdam; Netherlands
PB - Elsevier Science Publishers B.V, Biomedical Division
SN - 0006-8993
AD - Bagnyukova, T. V.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20083312561. Publication Type: Journal Article. Note: Special issue: Brains, genes and nutrition. Language: English. Number of References: 35 ref. Registry Number: 9007-49-2, 59-30-3, 70-18-8, 63-68-3. Subject Subsets: Human Nutrition
N2 - The age-associated decline in cellular antioxidant defenses and resultant accumulation of DNA damage in central nervous system has been mechanistically implicated in the etiology and pathogenesis of neurodegenerative diseases. Neurons possess a high metabolic activity and are especially vulnerable to the long-term effects of continuous exposure to endogenous reactive oxygen species. It is well recognized that adequate availability of essential nutrients involved in cellular one-carbon metabolism is essential for normal brain development and function. Additionally, the synthesis of the primary low-molecular cellular antioxidant glutathione is inter-dependently linked to one-carbon metabolic pathway. Thus, any aberrant disruptions in one-carbon metabolism can result in potentially deleterious effects including cell death as a result of an imbalance in the cellular redox state. Hence, in the present study, we examined the long-term effects of a folate/methyl-deficient (FMD) diet on cellular antioxidant defenses and DNA damage in the rat brain. Feeding male Fisher 344 rats a FMD diet resulted in perturbations in the levels of one-carbon metabolites along with induction of oxidative stress and oxidative DNA damage in the brain. This was evidenced by a decrease in the reduced oxidized/glutathione ratio, imbalance of cellular antioxidant defense system; specifically, altered activity and expression of antioxidant enzymes Mn-containing superoxide dismutase (Mn-SOD), catalase, and glutathione peroxidase (GPX), increased accumulation of oxidative DNA lesions, 8-hydroxydeoxyguanosine (8-OH-dG) and DNA single-strand breaks, even in the presence of increased expression of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase beta (Polβ), and apoptosis in the brains of folate/methyl-deficient rats. These results indicate that chronic methyl group deficiency leads to an imbalance in cellular antioxidant defense systems, increased oxidative stress, and apoptosis. Any of these events may compromise normal central nervous system function and contribute to the development of various neurological, behavioral, and neurocognitive dysfunctions.
KW - animal models
KW - antioxidants
KW - apoptosis
KW - brain
KW - DNA
KW - folic acid
KW - glutathione
KW - laboratory animals
KW - metabolism
KW - methionine
KW - neurons
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - deoxyribonucleic acid
KW - folacin
KW - folate
KW - nerve cells
KW - neurones
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083312561&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4T3DCXT-9&_user=6686535&_coverDate=10%2F27%2F2008&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234841%232008%23987629999%23699096%23FLA%23display%23Volume)&_cdi=4841&_sort=d&_docanchor=&_ct=22&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=3313be24e61ddf8f13eba89fc0a8e92e
UR - email: tetyana.bagnyukova@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Russian medicinal plants in treatment of cancer.
AU - Spiridonov, N. A.
A2 - Watson, R. R.
A2 - Preedy, V. R.
T2 - Botanical medicine in clinical practice
Y1 - 2008///
CY - Wallingford; UK
PB - CAB International
SN - 9781845934132
AD - Spiridonov, N. A.: Center for Drug Evaluation and Research, US Food and Drug Administration (HFD-122), Building 29A, Room 3B20, 29 Lincoln Drive, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093001753. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Several dozen species of medicinal plants were reputed in Russian folk medicine to alleviate symptoms of disease and improve conditions of cancer patients. An overview of experimental and clinical data on anticancer properties of phytotherapeutics and the use of medicinal plants in Russian traditional and officinal medicine for complementary treatment of cancer patients is presented in this chapter.
KW - anticancer properties
KW - herbal drugs
KW - medicinal plants
KW - traditional medicines
KW - Russia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - anti-cancer properties
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Russian Federation
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093001753&site=ehost-live&scope=site
UR - email: nikolay.spiridonov@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Campylobacter.
AU - Acheson, D. W. K.
A2 - Schlossberg, D.
T2 - Clinical infectious disease
Y1 - 2008///
CY - Cambridge; UK
PB - Cambridge University Press
SN - 9780521871129
AD - Acheson, D. W. K.: U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093328278. Publication Type: Book chapter. Language: English. Subject Subsets: Public Health
KW - antibacterial agents
KW - bacterial diseases
KW - clinical aspects
KW - diagnosis
KW - disease prevention
KW - drug therapy
KW - epidemiology
KW - human diseases
KW - medical treatment
KW - prognosis
KW - Campylobacter
KW - man
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - clinical picture
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093328278&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Shigella.
AU - Acheson, D. W. K.
A2 - Schlossberg, D.
T2 - Clinical infectious disease
Y1 - 2008///
CY - Cambridge; UK
PB - Cambridge University Press
SN - 9780521871129
AD - Acheson, D. W. K.: U.S. Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093328205. Publication Type: Book chapter. Language: English. Subject Subsets: Public Health
KW - bacterial diseases
KW - human diseases
KW - reviews
KW - shigellosis
KW - man
KW - Shigella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093328205&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Recycled plastics for food applications: improving safety and quality.
AU - Komolprasert, V.
AU - Bailey, A.
A2 - Chiellini, E.
T2 - Environmentally compatible food packaging
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2008///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 9781845691943
AD - Komolprasert, V.: Division of Food Contact Notifications (HFS-275), Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20083242668. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Number of References: 34 ref.
N2 - This chapter focuses on recent efforts at improving the safety and quality of recycled plastics for food-contact applications in the context of the Food and Drug Administration's recent recycled plastics guidance document (2006). Specific topics discussed are as follows: plastic food packaging and the environment, the recyclability of packaging plastics, recycling processes, improving the recyclability of plastic packaging for food use, safety and quality of recycled plastics and the use of recycled plastics in the food industry.
KW - environmental protection
KW - food industry
KW - food packaging
KW - food safety
KW - guidelines
KW - legislation
KW - packaging materials
KW - plastics
KW - recycling
KW - recommendations
KW - Pollution and Degradation (PP600)
KW - Food Storage and Preservation (QQ110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083242668&site=ehost-live&scope=site
UR - email: Vanee.Komolprasert@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Assessing the human health implications of new veterinary drugs used in fish farming.
AU - Reimschuessel, R.
A2 - Lie,Ø.
T2 - Improving farmed fish quality and safety
T3 - Woodhead Publishing in Food Science, Technology and Nutrition
Y1 - 2008///
CY - Cambridge; UK
PB - Woodhead Publishing Ltd
SN - 9781845692995
AD - Reimschuessel, R.: VMD, US Food and Drug Administration (USFDA), Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20083241597. Publication Type: Book chapter. Note: Woodhead Publishing in Food Science, Technology and Nutrition Language: English. Number of References: many ref. Subject Subsets: Human Nutrition
N2 - The topics covered in this chapter include: regulation of veterinary drug use; measurement of drug residues in foods; the peculiar aspects of veterinary drug use in fishes; exposure methods for fish drugs and potential human hazards; the factors affecting drug residue levels in fish (such as temperature, salinity, dose and duration); pharmacokinetics and withdrawal times of fish drugs and the risk of fish drugs to human health.
KW - dosage
KW - drug residues
KW - environmental impact
KW - fish culture
KW - pharmacokinetics
KW - risk
KW - salinity
KW - veterinary products
KW - water temperature
KW - fishes
KW - man
KW - vertebrates
KW - Chordata
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - animal health products
KW - environmental effects
KW - fish farming
KW - pisciculture
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Aquaculture (Animals) (MM120)
KW - Aquatic Biology and Ecology (MM300)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083241597&site=ehost-live&scope=site
UR - email: rreimsch@cvm.fda.gov\renate.reimschuessel@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Using risk analysis for microbial food safety regulatory decision making.
AU - Dennis, S. B.
AU - Kause, J.
AU - Losikoff, M.
AU - Engeljohn, D. L.
AU - Buchanan, R. L.
A2 - Schaffner, D. W.
T2 - Microbial risk analysis of foods
T3 - Emerging issues in food safety
Y1 - 2008///
CY - Washington; USA
PB - ASM Press
SN - 9781555814618\1555814611
AD - Dennis, S. B.: Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-006, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083022924. Publication Type: Book chapter. Note: Emerging issues in food safety Language: English. Number of References: 39 ref. Subject Subsets: Human Nutrition
N2 - This chapter discusses the use of a risk analysis framework within a food safety context with emphasis on microbiological/biological hazards, how risk analysis has been implemented in US regulatory agencies and international organizations, and future needs to strengthen the use of risk analysis to help solve food safety issues. Case studies illustrate more specifically how microbial risk assessments have informed decision making in US regulatory agencies.
KW - food
KW - food contamination
KW - food safety
KW - microbial contamination
KW - risk
KW - risk analysis
KW - risk reduction
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083022924&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Using risk assessment principles in an emerging paradigm for controlling the microbial safety of foods.
AU - Whiting, R. C.
AU - Buchanan, R. L.
A2 - Schaffner, D. W.
T2 - Microbial risk analysis of foods
T3 - Emerging issues in food safety
Y1 - 2008///
CY - Washington; USA
PB - ASM Press
SN - 9781555814618\1555814611
AD - Whiting, R. C.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20083022927. Publication Type: Book chapter. Note: Emerging issues in food safety Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - This chapter discusses different methods of risk assessment, including Hazard Analysis Critical Control Points (HAACP), Food Safety Objective (FSO), microbiological modelling and FSO/PO paradigm. The use of risk assessment to establish food safety is illustrated.
KW - food
KW - food contamination
KW - food safety
KW - microbial contamination
KW - risk
KW - risk analysis
KW - risk reduction
KW - food contaminants
KW - HAACP
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083022927&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Rapid methods for foodborne bacterial enumeration and pathogen detection.
AU - Feng, P.
AU - Heredia, N.
A2 - Heredia, N.
A2 - Wesley, I.
A2 - Garcia, S.
T2 - Microbiologically safe foods
Y1 - 2008///
CY - Chichester; UK
PB - Wiley-Blackwell
SN - 9780470439074
AD - Feng, P.: U.S. Food and Drug Administration, DMS, HFS-516, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20123134096. Publication Type: Book chapter. Language: English. Number of References: 27 ref. Subject Subsets: Public Health; Human Nutrition
N2 - This chapter provides an overview of recent technologies and advancements made in rapid enumeration methods as it relates to the analysis of foodborne pathogens. Practical issues and logistical challenges relevant to these rapid enumeration methods in food testing are also discussed.
KW - detection
KW - enumeration
KW - food contamination
KW - food safety
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - rapid methods
KW - techniques
KW - food contaminants
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20123134096&site=ehost-live&scope=site
UR - http://onlinelibrary.wiley.com/doi/10.1002/9780470439074.ch27/pdf
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Licensing of pneumococcal conjugate vaccines for children and adults: regulatory perspective from the European medicines agency and the U.S. food and drug administration.
AU - Gruber, M. F.
AU - Pratt, D.
AU - Haase, M.
A2 - Siber, G. R.
A2 - Klugman, K. P.
A2 - Mäkelä, P. H.
T2 - Pneumococcal vaccines: the impact of conjugate vaccine
Y1 - 2008///
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 9781555814033
AD - Gruber, M. F.: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, WOC I, 360 North, Rockville, MD 20852, USA.
N1 - Accession Number: 20083093823. Publication Type: Book chapter. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - This chapter provides European Union and US regulatory perspectives for the licensure of pneumococcal conjugate vaccines indicated for the paediatric and adult populations. It is noted that clinical end point efficacy studies to demonstrate clinical benefit from second-generation pneumococcal conjugate vaccines in the prelicensure setting have become difficult to conduct, and that new regulatory approaches to guide the path to licensure for these products have been necessary.
KW - adults
KW - bacterial diseases
KW - children
KW - clinical trials
KW - conjugate vaccines
KW - EU regulations
KW - human diseases
KW - immunization
KW - licences
KW - regulations
KW - vaccination
KW - vaccine development
KW - European Union
KW - USA
KW - man
KW - Streptococcus pneumoniae
KW - Europe
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Streptococcus
KW - Streptococcaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Common Market
KW - EC
KW - EC regulations
KW - EEC
KW - European Communities
KW - European Economic Communities
KW - immune sensitization
KW - licenses
KW - licensing
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20083093823&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Hazards of dietary furan.
AU - Bolger, P. M.
AU - Tao, S. S. H.
AU - Dinovi, M.
A2 - Stadler, R. H.
A2 - Lineback, D. R.
T2 - Process-induced food toxicants: occurrence, formation, mitigation and health risks
Y1 - 2008///
CY - Chichester; UK
PB - Wiley-Blackwell
SN - 9780470430101
AD - Bolger, P. M.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20123125561. Publication Type: Book chapter. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - This chapter focuses on dietary furans, highlighting its analysis and occurrence in foods, mitigation/reduction, metabolism and toxicokinetics, toxicity to humans, and mechanism of action.
KW - chemical reactions
KW - exposure
KW - food processing
KW - food safety
KW - foods
KW - furans
KW - metabolism
KW - mode of action
KW - reviews
KW - toxic substances
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - poisons
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Chemistry (QQ600) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20123125561&site=ehost-live&scope=site
UR - http://onlinelibrary.wiley.com/doi/10.1002/9780470430101.ch2d/summary
UR - email: Mike.Bolger@fda.hhs.gov\shyyhwa.tao@fda.hhs.gov\michael.dinovi@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prophylactic and therapeutic vaccination against Hepatitis C Virus (HCV): developments and future perspectives.
AU - Major, M. E.
JO - Viruses
JF - Viruses
Y1 - 2009///
VL - 1
IS - 2
SP - 144
EP - 165
CY - Basel; Switzerland
PB - Molecular Diversity Preservation International (MDPI)
SN - 1999-4915
AD - Major, M. E.: Division of Viral Products, Center for Biologics, Food and Drug Administration, Bldg 29A/Rm 1D10, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20103252093. Publication Type: Journal Article. Language: English. Number of References: 121 ref. Subject Subsets: Public Health
N2 - Studies in patients and chimpanzees that spontaneously clear Hepatitis C Virus (HCV) have demonstrated that natural immunity to the virus is induced during primary infections and that this immunity can be cross protective. These discoveries led to optimism regarding prophylactic HCV vaccines and a number of studies in the chimpanzee model have been performed, all of which resulted in modified infections after challenge but did not always prevent persistence of the virus. Therapeutic vaccine strategies have also been pursued in an effort to reduce the costs and side effects associated with anti-viral drug treatment. This review summarizes the studies performed thus far in both patients and chimpanzees for prophylactic and therapeutic vaccination, assesses the progress made and future perspectives.
KW - hepatitis C
KW - human diseases
KW - reviews
KW - vaccination
KW - vaccines
KW - Hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103252093&site=ehost-live&scope=site
UR - http://www.mdpi.com/1999-4915/1/2/144/pdf
UR - email: marian.major@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of total arsenic and arsenic speciation in US-produced rice as a reference point for evaluating change and future trends.
AU - Heitkemper, D. T.
AU - Kubachka, K. M.
AU - Halpin, P. R.
AU - Allen, M. N.
AU - Shockey, N. V.
JO - Food Additives and Contaminants B, Surveillance
JF - Food Additives and Contaminants B, Surveillance
Y1 - 2009///
VL - 2
IS - 2
SP - 112
EP - 120
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1939-3210
AD - Heitkemper, D. T.: US Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA.
N1 - Accession Number: 20103003593. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 7440-38-2. Subject Subsets: Rice; Postharvest Research
N2 - Rice generally contains higher levels of arsenic than most terrestrial-based foods. Studies related to dietary intake of arsenic from rice must take into account arsenic speciation due to toxicity differences in arsenic species. In this study, microwave-assisted extraction with trifluoroacetic acid was used to prepare rice samples for arsenic speciation analysis by high-performance liquid chromatography-inductively coupled plasma mass spectrometry. Fifty-three samples collected directly from the fields in four major rice-producing states in 1980 and 1981 were analysed for total and speciated arsenic and the results were compared with each other and with results for several more recently collected samples from local markets. The average content of total arsenic was 210±190 ng As g-1. This study demonstrates that US rice samples with higher levels of total arsenic have higher levels of dimethylarsinic acid; however, inorganic arsenic levels, regardless of the total arsenic content, rarely exceed 150 ng As g-1 dry weight. These data are consistent with more recent findings, thus establishing trends that arsenic content in US-grown rice has been relatively constant throughout the last 30 years. To the authors' knowledge, the presented data are unique in that they provide a historical reference point for arsenic distribution in US-produced rice. These data would be invaluable for several applications including long-term arsenic exposure studies, environmental clean-up assessments, and to establish models for future trends in arsenic contribution in total diet studies.
KW - arsenic
KW - chemical speciation
KW - contaminants
KW - rice
KW - toxicity
KW - trends
KW - Oryza
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - paddy
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Chemistry (QQ600) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103003593&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/title~content=t783462596~db=all
UR - email: douglas.heitkemper@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the hydrophobic grid membrane filter for the enumeration of moulds and yeasts in naturally-contaminated foods.
AU - Tournas, V. H.
JO - Microbiology Insights
JF - Microbiology Insights
Y1 - 2009///
VL - 2
SP - 31
EP - 37
CY - Auckland; New Zealand
PB - Libertas Academica
SN - 1178-6361
AD - Tournas, V. H.: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20113352131. Publication Type: Journal Article. Language: English. Number of References: 8 ref. Subject Subsets: Medical & Veterinary Mycology
N2 - Over 240 food samples from six food groups (tree nuts, grains and grain products, dried fruits, fresh produce, fruit juice, and dairy products) were tested for levels of fungal contamination using the NEO-GRID hydrophobic grid membrane filter (HGMF) and the FDA official (BAM) method. Results showed that HGMF performed very well for all tested commodities giving yeast and mould (YM) counts similar to those of the BAM (reference) method. Statistical analysis of the data (t-test) revealed no significant differences between the two methods for all foods tested. Regression analysis showed that there was a good fit linear relationship between the two methods for most of the commodities examined. Some difficulties were encountered during counting of the colonies on HGMF since the size of the grid is very small and the number of possible colonies per plate can reach 1600.
KW - food
KW - food contamination
KW - microbial contamination
KW - moulds
KW - yeasts
KW - fungi
KW - eukaryotes
KW - food contaminants
KW - fungus
KW - molds
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113352131&site=ehost-live&scope=site
UR - http://www.la-press.com/evaluation-of-the-hydrophobic-grid-membrane-filter-for-the-enumeration-article-a1560
UR - email: valerie.tournas@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and molecular epidemiology of respiratory syncytial virus type A and B strains in childhood respiratory infections in Hungary.
AU - Pankovics, P.
AU - Szabó, H.
AU - Székely, G.
AU - Gyurkovits, K.
AU - Reuter, G.
JO - Clinical and Experimental Medical Journal
JF - Clinical and Experimental Medical Journal
Y1 - 2009///
VL - 3
IS - 1
SP - 87
EP - 97
CY - Budapest; Hungary
PB - Akadémiai Kiadó
SN - 2060-6249
AD - Pankovics, P.: Regional Laboratory of Virology ÁNTSZ, Regional Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20113060566. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - The human respiratory syncytial virus (hRSV) is one of the major causes of respiratory infection of infants and children worldwide. The molecular epidemiology of hRSV is unknown in Hungary. Aims: Our aims were the molecular detection and genetic analysis of hRSV from childhood respiratory infections in Hungary. Materials and methods: Nasopharyngeal aspirates collected from children under the age of 10 years with acute respiratory infections were provided by Pediatric Department of the Hospital for Chest Diseases in Mosdós. Samples were taken from 15 October to 15May in seasons 2005/2006 and 2006/2007. The clinical and epidemiological data were collected prospectively. The amplification of the surface fusion glycoprotein (F) and the attachment glycoprotein (G) genes of viral RNA was made by RTPCR method. PCR-products were sequenced and analyzed by phylogenetic analysis. Results: Nasopharyngeal aspirates of 104 children were examined out of which 23 (22.1%) samples - 16 males (69.6%) and 7 females (30.4%) - (first season: 1/49, 2%; second season: 22/55, 40%) contained hRSV. The hRSV infections were taking place from December toMarch. The average age was 2.1 years (1 month to 8 years). The leading symptoms were dropping nose, fever, cough and wheezing. 39.1% of the hRSV infected children had underlying diseases. Based upon the F region, 22 (96%) viruses genetically belonged to the type A and 1 (4%) was classified as type B hRSV. Based upon the G region out of the 11 type A viruses 8 (72.7%) belonged to group GA5 and 3 (27.3%) to group GA2. Viral nucleotide sequence was identical in several cases. Conclusions: To our knowledge, this is the first report on molecular detection and genetic analysis of the two types (A and B) of hRSV of children under the age of 10 with respiratory infections in Hungary. In winter and spring hRSV is an important cause of childhood respiratory infections particularly in infants, which often require hospitalization.
KW - children
KW - clinical aspects
KW - diagnosis
KW - diagnostic techniques
KW - disease incidence
KW - disease prevalence
KW - epidemiology
KW - genetic analysis
KW - human diseases
KW - molecular epidemiology
KW - molecular genetics
KW - molecular genetics techniques
KW - nucleotide sequences
KW - phylogenetics
KW - respiratory diseases
KW - symptoms
KW - Hungary
KW - Human respiratory syncytial virus
KW - man
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - clinical picture
KW - DNA sequences
KW - lung diseases
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113060566&site=ehost-live&scope=site
UR - http://www.akademiai.com/content/1343815605117080/fulltext.pdf
UR - email: pankovics.peter@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A miniaturized assay for influenza neuraminidase-inhibiting antibodies utilizing reverse genetics-derived antigens.
AU - Sandbulte, M. R.
AU - Gao, J.
AU - Straight, T. M.
AU - Eichelberger, M. C.
JO - Influenza and other Respiratory Viruses
JF - Influenza and other Respiratory Viruses
Y1 - 2009///
VL - 3
IS - 5
SP - 233
EP - 240
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1750-2640
AD - Sandbulte, M. R.: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20093253554. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Public Health
N2 - Background: Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sialic acid following incubation of NA with substrate in the presence of serum. In addition, the assay is complicated by the need to use virus of a hemagglutinin (HA) subtype novel to the host to detect NA-specific antibodies only. Objectives: Our primary objectives were to miniaturize the colorimetric NI assay to a format suitable for quantitative analysis of large numbers of samples, and validate the specificity and sensitivity of the miniaturized format with ferret and human sera. An additional aim was to use reverse genetics to construct HA-mismatched viral reagents bearing NA of recent influenza A vaccine strains and H6 HA. Results: Analysis of ferret antisera by the miniaturized assay demonstrated sensitivity and specificity comparable with the conventional assay. Similar increases in the NI titers in sera from vaccinated human volunteers were measured in miniaturized and conventional assays. Inactivated and live-attenuated vaccines increased NI titers against a given subtype at approximately the same rate. Conclusions: The reagents and miniaturized format of the TBA method described here provide a platform for practical serological monitoring of functional antibodies against NA.
KW - assays
KW - human diseases
KW - influenza
KW - Influenza viruses
KW - methodology
KW - respiratory diseases
KW - serology
KW - techniques
KW - vaccination
KW - vaccines
KW - viral diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - flu
KW - lung diseases
KW - methods
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093253554&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/irv
UR - email: matthew.sandbulte@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Special Issue: Pandemic influenza 2009.
AU - Yeskey, K.
A2 - Yeskey, K.
T2 - Disaster Medicine and Public Health Preparedness
JO - Disaster Medicine and Public Health Preparedness
JF - Disaster Medicine and Public Health Preparedness
Y1 - 2009///
VL - 3
IS - Suppl. 2
SP - S91
EP - S210
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins, Inc.,
SN - 1935-7893
AD - Yeskey, K.: Office of Preparedness and Emergency Operations, US Department of Health and Human Services, Washington, Dist. of Columbia, USA.
N1 - Accession Number: 20103244089. Publication Type: Journal issue. Language: English. Subject Subsets: Tropical Diseases; Rural Development
N2 - This supplement includes 17 articles and commentaries focusing on medical and public health response to the 2009 H1N1 influenza pandemic. The topics discussed are: observations of past influenza pandemics; H1N1 influenza outbreaks; monitoring of H1N1 vaccine doses administered; uncertainty and operational considerations in mass prophylaxis workforce planning; mitigating absenteeism in hospital workers during a pandemic; media reporting of the emergence of the 1968 influenza pandemic in Hong Kong, China, and its implications for modern-day situational awareness; ethical, legal and practical principles to guide the equitable allocation of limited resources and establishment of altered standards of care protocols during an influenza pandemic; assessment of routine annual influenza prevention and control systems in the USA; prehospital experience of the 2009 novel H1N1 outbreak in Victoria, Australia; paediatric considerations in extending and rationing care in public health emergencies; implications of the Emergency Medical Treatment and Labour Act during public health emergencies and on alternate sites of care; emergency legal preparedness among select US local governments; ethical guidelines in pandemic influenza; point-of-care testing for pandemic influenza and biothreats; and safety of health care workers responding to the pandemic.
KW - children
KW - data collection
KW - disease control
KW - disease prevention
KW - emergencies
KW - ethics
KW - health care
KW - health care workers
KW - health services
KW - human diseases
KW - immunization
KW - influenza A
KW - law
KW - legislation
KW - mass media
KW - monitoring
KW - outbreaks
KW - planning
KW - public health
KW - safety at work
KW - vaccination
KW - vaccines
KW - Australia
KW - China
KW - Hong Kong
KW - USA
KW - Victoria
KW - Influenza A virus
KW - man
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Australasia
KW - Oceania
KW - Commonwealth of Nations
KW - Developed Countries
KW - OECD Countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Central Southern China
KW - China
KW - North America
KW - America
KW - Australia
KW - data logging
KW - H1N1 subtype influenza A virus
KW - immune sensitization
KW - legal aspects
KW - legal principles
KW - news media
KW - occupational safety
KW - pandemics
KW - People's Republic of China
KW - point-of-care systems
KW - surveillance systems
KW - United States of America
KW - Xianggang
KW - Laws and Regulations (DD500)
KW - Host Resistance and Immunity (HH600)
KW - Health Services (UU350)
KW - Communication and Mass Media (UU360)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103244089&site=ehost-live&scope=site
UR - http://www.dmphp.org/content/vol3/Supplement_2/index.dtl
UR - email: kevin.yeskey@hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Implications of the emergency medical treatment and labor act (EMTALA) during public health emergencies and on alternate sites of care.
AU - Roszak, A. R.
AU - Jensen, F. R.
AU - Wild, R. E.
AU - Yeskey, K.
AU - Handrigan, M. T.
A2 - Yeskey, K.
T3 - Special Issue: Pandemic influenza 2009.
JO - Disaster Medicine and Public Health Preparedness
JF - Disaster Medicine and Public Health Preparedness
Y1 - 2009///
VL - 3
IS - Suppl. 2
SP - S172
EP - S175
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins, Inc.,
SN - 1935-7893
AD - Roszak, A. R.: US Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Senior Public Health Advisor, Emergency Care Coordination Center, Switzer Bldg Room 5217, 200 Independence Ave SW, Washington, DC 20201, USA.
N1 - Accession Number: 20103244107. Publication Type: Journal Article. Note: Special Issue: Pandemic influenza 2009. Language: English. Number of References: 29 ref. Subject Subsets: Public Health
N2 - Hospitals throughout the country are using innovative strategies to accommodate the surge of patients brought on by the novel H1N1 virus. One strategy has been to help decompress the amount of patients seeking care within emergency departments by using alternate sites of care, such as tents, parking lots, and community centers as triage, staging, and screening areas. As at any other time an individual presents on hospital property, hospitals and providers must be mindful of the requirements of the Emergency Medical Treatment and Labor Act. In this article we review the act and its implications during public health emergencies, with a particular focus on its implications on alternative sites of care.
KW - emergencies
KW - health care
KW - law
KW - medical treatment
KW - public health
KW - District of Columbia
KW - USA
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - legal aspects
KW - legal principles
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103244107&site=ehost-live&scope=site
UR - http://www.dmphp.org/cgi/content/full/3/Supplement_2/S172
UR - email: andrew.roszak@hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Breastfeeding and health outcomes.
AU - Meyers, D.
JO - Breastfeeding Medicine
JF - Breastfeeding Medicine
Y1 - 2009///
VL - 4
IS - s1
SP - S
EP - 15
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1556-8253
AD - Meyers, D.: Center for Primary Care, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20093303706. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Human Nutrition; Dairy Science
KW - breast feeding
KW - health
KW - infants
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093303706&site=ehost-live&scope=site
UR - http://www.liebertonline.com/loi/bfm
UR - email: david.meyers@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Molecular characterization of tetracycline-resistant genes and integrons from avirulent strains of Escherichia coli isolated from catfish.
AU - Nawaz, M.
AU - Khan, A. A.
AU - Khan, S.
AU - Sung, K. D.
AU - Kerdahi, K.
AU - Steele, R.
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
Y1 - 2009///
VL - 6
IS - 5
SP - 553
EP - 559
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1535-3141
AD - Nawaz, M.: Division of Microbiology, National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20093231335. Publication Type: Journal Article. Language: English. Registry Number: 60-54-8, 64-75-5. Subject Subsets: Human Nutrition
N2 - A study was undertaken to investigate the occurrence of tetracycline-resistant genes and to characterize the integrons present in Escherichia coli isolated from catfish. Sixty-three tetracycline-resistant E. coli strains were isolated from the intestinal contents of 407 farm-raised catfish. All strains were resistant to multiple antibiotics. A polymerase chain reaction (PCR) assay detected tetA in the DNA of 15 of 63 (25.0%) isolates by amplifying a PCR amplicon measuring 957 bp. Oligonucleotide primers targeting a 436-bp region of tetB successfully amplified a PCR amplicon from 47 of 63 (77.0%) isolates, indicating that tetB was predominant. Oligonucleotide primers specific for tetC amplified a 589-bp PCR amplicon from 3 of 63 (5%) isolates. Eleven (17.0%) of the isolates contained both tetA and tetB genes. Class I integrons amplified from the genomic DNA of 14 of 63 (22.0%) isolates measured 1.6 and 1.8 kb. Sequence analysis of the 1.6 kb integrons indicated the presence of three different gene cassettes: a dfrA12, conferring resistance to trimethoprim; an open reading frame, orfF, a hypothetical protein of unknown function; and aadA2, conferring resistance to aminoglycosides. Sequence analysis of the 1.8-kb integron indicated the presence of dfrA17 and aadA5. PCR assays for the detection of the six predominant virulence genes failed to amplify any genes from the genomic DNA. Pulsed-field gel electrophoresis using XbaI identified 16 distinct macro restriction patterns among the 63 isolates. The dendrogram analysis indicated that the DNA from 4 of 16 isolates had a similarity index of 90.0%. Our results indicate that the use of oxytetracycline and Romet 30 (sulfadimethoxine and ormetoprim) in farm-raised catfish may select for multiple antibiotic-resistant E. coli that could serve as a reservoir of tetracycline, trimethoprim, and aminoglycoside resistance genes.
KW - antibacterial agents
KW - antibiotics
KW - drug resistance
KW - genes
KW - nucleotide sequences
KW - resistance mechanisms
KW - tetracycline
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - achromycin
KW - bacterium
KW - catfish
KW - DNA sequences
KW - E. coli
KW - integrons
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Aquaculture (Animals) (MM120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093231335&site=ehost-live&scope=site
UR - http://www.liebertonline.com/doi/abs/10.1089/fpd.2008.0204
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Differentiation of whole bacterial cells based on high-throughput microarray chip printing and infrared microspectroscopic readout.
AU - Al-Khaldi, S. F.
AU - Mossoba, M. M.
AU - Burke, T. L.
AU - Fry, F. S.
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
Y1 - 2009///
VL - 6
IS - 8
SP - 1001
EP - 1007
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1535-3141
AD - Al-Khaldi, S. F.: Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA.
N1 - Accession Number: 20093285995. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition
N2 - Using robotic automation, a microarray printing protocol for whole bacterial cells was developed for subsequent label-free and nondestructive infrared microspectroscopic detection. Using this contact microspotting system, 24 microorganisms were printed on zinc selenide slides; these were 6 species of Listeria, 10 species of Vibrio, 2 strains of Photobacterium damselae, Yersinia enterocolitica 289, Bacillus cereus ATCC 14529, Staphylococcus aureus, ATCC 19075 (serotype 104 B), Shigella sonnei 20143, Klebsiella pneumoniae KP73, Enterobacter cloacae, Citrobacter freundii 200, and Escherichia coli. Microarrays consisting of separate spots of bacterial deposits gave consistent and reproducible infrared spectra, which were differentiated by unsupervised pattern recognition algorithms. Two multivariate analysis algorithms, principal component analysis and hierarchical cluster analysis, successfully separated most, but not all, the bacteria investigated down to the species level.
KW - DNA microarrays
KW - infrared spectroscopy
KW - molecular genetics techniques
KW - Bacillus cereus
KW - Citrobacter freundii
KW - Enterobacter cloacae
KW - Escherichia coli
KW - Listeria
KW - Photobacterium damselae
KW - Vibrio
KW - Yersinia enterocolitica
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Citrobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Enterobacter
KW - Escherichia
KW - Listeriaceae
KW - Photobacterium
KW - Vibrionaceae
KW - Vibrionales
KW - Yersinia (Bacteria)
KW - bacterium
KW - E. coli
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093285995&site=ehost-live&scope=site
UR - http://www.liebertonline.com/fpd
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Climate change and occupational safety and health: establishing a preliminary framework.
AU - Schulte, P. A.
AU - Chun, H. K.
JO - Journal of Occupational and Environmental Hygiene
JF - Journal of Occupational and Environmental Hygiene
Y1 - 2009///
VL - 6
IS - 9
SP - 542
EP - 554
CY - Abingdon; UK
PB - Taylor & Francis
SN - 1545-9624
AD - Schulte, P. A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20093199018. Publication Type: Journal Article. Language: English. Number of References: 136 ref.
N2 - The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks.
KW - climate
KW - literature reviews
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - occupational safety
KW - Meteorology and Climate (PP500)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093199018&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~db=all~content=a912624827
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative analysis of cell culture and prediction algorithms for phenotyping of genetically diverse HIV-1 strains from Cameroon.
AU - Ragupathy, V.
AU - Zhao, J. Q.
AU - Wang, X.
AU - Wood, O.
AU - Lee, S.
AU - Burda, S.
AU - Nyambi, P.
AU - Hewlett, I.
JO - AIDS Research and Therapy
JF - AIDS Research and Therapy
Y1 - 2009///
VL - 6
IS - 27
SP - (25 November 2009)
EP - (25 November 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1742-6405
AD - Ragupathy, V.: Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20103011338. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Tropical Diseases
N2 - Background: With the advent of entry inhibitors, monitoring of viral tropism in the clinical setting is important. Conventional methods are cell-based and lengthy, therefore V3 sequence based prediction algorithms are becoming increasingly attractive as monitoring tools. Here we report a comparative analysis of viral tropism of strains circulating in Cameroon where diverse and emerging variant strains are prevalent. Methods: Viruses were isolated from 17 HIV positive individuals from three cities in Cameroon. Ghost cell lines expressing either CCR5 or CXCR4 with CD4 or CD4 alone (NIH AIDS Reagent Program) were used to determine co-receptor usage. HIV replication was determined by measuring p24 antigen levels. Plasma viral load (VL) was determined using the Versant bDNA assay. Nucleotide sequencing was performed on the V3 region and sequences were edited, aligned and translated into amino acids as described in the algorithm. Bio-informatics tools based on the 11/25 and charge rule were used to predict co-receptor usage. Results: The majority of patient isolates in our study were CRF02_AG or CRF02_AG containing recombinants. Tropism of these complex viruses based on the cell culture assay was determined to be R5 in 15/17 (88.2%) patients. However, two patient isolates were dual tropic R5X4 and had drug-specific mutations. Of these two patients, one was on antiretroviral treatment with a VL of 20,899 copies/ml and the other was drug-naïve with 141,198 copies/ml. Genotype based prediction was overall in good agreement with phenotype for R5 viruses, where 93% (14/15) of results were comparable, dual tropic viruses being reported as X4 viruses by prediction. Conclusion: Our results indicate that most HIV strains in Cameroon were R5 tropic and some harbored drug-resistant mutations. V3 sequence based prediction compared well with cell based assays for R5 strains and may be useful even in settings where highly diverse strains are prevalent.
KW - algorithms
KW - antigens
KW - cell culture
KW - HIV-1 infections
KW - human diseases
KW - molecular genetics
KW - molecular genetics techniques
KW - mutations
KW - nucleotide sequences
KW - strains
KW - viral diseases
KW - viral replication
KW - Cameroon
KW - Human immunodeficiency virus 1
KW - man
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Central Africa
KW - Africa South of Sahara
KW - Africa
KW - Developing Countries
KW - Francophone Africa
KW - antigenicity
KW - biochemical genetics
KW - DNA sequences
KW - immunogens
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103011338&site=ehost-live&scope=site
UR - http://www.aidsrestherapy.com/content/6/1/27
UR - email: viswanath.ragupathy@fda.hhs.gov\Jiangqin.Zhao@fda.hhs.gov\xue.wang@fda.hhs.gov\owen.wood@fda.hhs.gov\sherwin.lee@fda.hhs.gov\Sherri.Burda@nyumc.org\Phillipe.Nyambi@nyumc.org\indira.hewlett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Medication assisted treatment in the treatment of drug abuse and dependence in HIV/AIDS infected drug users.
AU - Kresina, T. F.
AU - Bruce, R. D.
AU - McCance-Katz, E. F.
JO - Current HIV Research
JF - Current HIV Research
Y1 - 2009///
VL - 7
IS - 4
SP - 354
EP - 364
CY - Hilversum; Netherlands
PB - Bentham Science Publishers BV
SN - 1570-162X
AD - Kresina, T. F.: Division of Pharmacological Therapies, Center for Substance Abuse Treatment, SAMHSA, 1 Choke Cherry Road, Rockville, MD 20857, USA.
N1 - Accession Number: 20093206888. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviours. The intersection of the twin epidemics of HIV and drug/alcohol use results in difficult medical management issues for the health care providers and researchers who work in the expanding global HIV prevention and treatment fields. Access to care and treatment, medication adherence to multiple therapeutic regimens, and concomitant drug-drug interactions of prescribed treatments are difficult barriers for drug users to overcome without directed interventions. Injection drug users are frequently disenfranchised from medical care and suffer stigma and discrimination creating additional barriers to care and treatment for their drug abuse and dependence as well as HIV infection. In an increasing number of studies, medication assisted treatment of drug abuse and dependence has been shown to be an important HIV prevention intervention. Controlling the global transmission of HIV will require further investment in evidence-based interventions and programs to enhance access to care and treatment of individuals who abuse illicit drugs and alcohol. In this review, we present the cumulative evidence of the importance of medication assisted treatment in the prevention, care and treatment of HIV-infected individuals who also abuse drugs and alcohol.
KW - alcohol intake
KW - alcoholism
KW - drug addiction
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - injecting drug abuse
KW - injecting drug users
KW - medical treatment
KW - reviews
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alcohol consumption
KW - chemotherapy
KW - human immunodeficiency virus infections
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093206888&site=ehost-live&scope=site
UR - http://www.benthamdirect.org/pages/content.php?CHR/2009/00000007/00000004/001AB.SGM
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pathways into homelessness: recently homeless adults problems and service use before and after becoming homeless in Amsterdam.
AU - Laere, I. R. van
AU - Wit, M. A. de
AU - Klazinga, N. S.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2009///
VL - 9
IS - 3
SP - (7 January 2009)
EP - (7 January 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2458
AD - Laere, I. R. van: GGD Municipal Public Health Service, Amsterdam, Netherlands.
N1 - Accession Number: 20093043150. Publication Type: Journal Article. Language: English. Number of References: 29 ref. Registry Number: 50-36-2, 53-21-4, 5913-62-2, 5913-65-5. Subject Subsets: Public Health
N2 - Background: To improve homelessness prevention practice, we met with recently homeless adults, to explore their pathways into homelessness, problems and service use, before and after becoming homeless. Methods: Recently homeless adults (last housing lost up to two years ago and legally staying in the Netherlands) were sampled in the streets, day centres and overnight shelters in Amsterdam. In April and May 2004, students conducted interviews and collected data on demographics, self reported pathways into homelessness, social and medical problems, and service use, before and after becoming homeless. Results: among 120 recently homeless adults, (male 88%, Dutch 50%, average age 38 years, mean duration of homelessness 23 weeks), the main reported pathways into homelessness were evictions 38%, relationship problems 35%, prison 6% and other reasons 22%. Compared to the relationship group, the eviction group was slightly older (average age 39.6 versus 35.5 years; p=0.08), belonged more often to a migrant group (p=0.025), and reported more living single (p<0,001), more financial debts (p=0.009), more alcohol problems (p=0.048) and more contacts with debt control services (p=0.009). The relationship group reported more domestic conflicts (p<0.001) and tended to report more drug (cocaine) problems. Before homelessness, in the total group, contacts with any social service were 38% and with any medical service 27%. Despite these contacts they did not keep their house. During homelessness only contacts with social work and benefit agencies increased, contacts with medical services remained low. Conclusion: the recently homeless fit the overall profile of the homeless population in Amsterdam: single (Dutch) men, around 40 years, with a mix of financial debts, addiction, mental and/or physical health problems. Contacts with services were fragmented and did not prevent homelessness. For homelessness prevention, systematic and outreach social medical care before and during homelessness should be provided.
KW - addiction
KW - adults
KW - alcoholism
KW - cocaine
KW - conflict
KW - drug abuse
KW - family problems
KW - homeless people
KW - medical services
KW - mental health
KW - psychosocial aspects
KW - social services
KW - socioeconomic status
KW - Netherlands
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - drug use
KW - Public Services and Infrastructure (UU300)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093043150&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2458/9/3
UR - email: ivlaere@ggd.amsterdam.nl\MdWit@ggd.amsterdam.nl\N.S.Klazinga@amc.uva.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of seasonal patterns of Kawasaki syndrome- and rotavirus-associated hospitalizations in California and New York, 2000-2005.
AU - MacNeil, A.
AU - Holman, R. C.
AU - Yorita, K. L.
AU - Steiner, C. A.
AU - Parashar, U. D.
AU - Belay, E. D.
JO - BMC Pediatrics
JF - BMC Pediatrics
Y1 - 2009///
VL - 9
IS - 65
SP - (16 October 2009)
EP - (16 October 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2431
AD - MacNeil, A.: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20093331472. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - Background: Kawasaki Syndrome (KS) is an uncommon childhood disease with unknown etiology. It has been suggested that rotavirus infection may play a causative role in the development of KS. Methods: To examine potential temporal associations between KS and rotavirus infection, seasonal patterns of KS- and rotavirus-associated hospitalizations among children in California and New York during 2000-2005 were compared. Results: Rotavirus hospital admissions were markedly winter seasonal, with very few summer hospitalizations. KS hospitalizations occurred year-round but also peaked slightly during winter and spring. Conclusion: The strong winter seasonal pattern of rotavirus clearly differed from the year-round pattern of KS hospitalizations. While the present study cannot completely rule out rotavirus as having a role in the development of KS, other agents must be involved in the etiology of KS.
KW - diarrhoea
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - Kawasaki disease
KW - seasonal variation
KW - viral diseases
KW - California
KW - New York
KW - USA
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Middle Atlantic States of USA
KW - Northeastern States of USA
KW - diarrhea
KW - mucocutaneous lymph node syndrome
KW - scouring
KW - seasonal changes
KW - seasonal fluctuations
KW - United States of America
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093331472&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2431/9/65
UR - email: aho3@cdc.gov\rch1@cdc.gov\KYorita@cdc.gov\Claudia.Steiner@ahrq.hhs.gov\uap2@cdc.gov\ebb8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Gamma-phage lysin PlyG sequence-based synthetic peptides coupled with Qdot-nanocrystals are useful for developing detection methods for Bacillus anthracis by using its surrogates, B. anthracis-sterne and B. cereus-4342.
AU - Sainathrao, S.
AU - Mohan, K. V. K.
AU - Atreya, C.
JO - BMC Biotechnology
JF - BMC Biotechnology
Y1 - 2009///
VL - 9
IS - 67
SP - (22 July 2009)
EP - (22 July 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1472-6750
AD - Sainathrao, S.: Section of Cell biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093246114. Publication Type: Journal Article. Language: English. Number of References: 25 ref. Subject Subsets: Public Health
N2 - Background: Previous reports of site-directed deletion analysis on gamma (γ)-phage lysin protein (PlyG) have demonstrated that removal of a short amino acid sequence in the C-terminal region encompassing a 10-amino acid motif (190LKMTADFILQ199) abrogates its binding activity specific to the cell wall of Bacillus anthracis. Whether short synthetic peptides representing the10-amino acid PlyG putative binding motif flanked by surrounding N- and C-terminal residues also selectively bind to the bacterial cell wall has not been evaluated. If such peptides do demonstrate selective binding to the cell wall, they could serve as bio-probes towards developing detection technologies for B. anthracis. Furthermore, by using B. anthracis (Sterne, 34F2), an animal vaccine and B. cereus-4342, a γ-phage susceptible rare strain as surrogates of B. anthracis, development of proof-of-concepts for B. anthracis are feasible. Results: Using four different methods, we evaluated six synthetic peptides representing the putative binding motif including flanking sequences (PlyG-P1 through P6) for the bacterial cell wall binding capacity. Our analysis identified PlyG-P1, PlyG-P3 and PlyG-P5 to have binding capability to both B. anthracis (Sterne, 34F2) and B. cereus-4342. The peptides however did not bind to B. cereus-11778, B. thuringiensis, and B. cereus-10876 suggesting their specificity for B. anthracis-Sterne and B. cereus-4342. PlyG-P3 in combination with fluorescent light microscopy detected even a single bacterium in plasma spiked with the bacteria. Conclusion: Overall, these studies illustrate that the short 10-amino acid sequence 'LKMTADFILQ' in fact is a stand-alone bacterial cell wall-binding motif of PlyG. In principle, synthetic peptides PlyG-P1, PlyG-P3 and PlyG-P5, especially PlyG-P3 coupled with Qdot-nanocrystals are useful as high-sensitivity bio-probes in developing detection technologies for B. anthracis.
KW - amino acid sequences
KW - anthrax
KW - cell walls
KW - deletions
KW - diagnosis
KW - diagnostic techniques
KW - DNA binding motifs
KW - nucleotide sequences
KW - proteins
KW - synthetic peptides
KW - vaccines
KW - Bacillus anthracis
KW - Bacillus cereus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - DNA sequences
KW - protein sequences
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093246114&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1472-6750/9/67
UR - email: shilpakala.sainathrao@fda.hhs.gov\krishna.ketha@fda.hhs.gov\chintamani.atreya@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A Mycobacterium tuberculosis cluster demonstrating the use of genotyping in urban tuberculosis control.
AU - Vries, G. de
AU - Hest, R. A. H. van
AU - Burdo, C. C. A.
AU - Soolingen, D. van
AU - Richardus, J. H.
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
Y1 - 2009///
VL - 9
IS - 151
SP - (08 Se
EP - (08 Se
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2334
AD - Vries, G. de: Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20093284457. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - Background: DNA fingerprinting of Mycobacterium tuberculosis isolates offers better opportunities to study links between tuberculosis (TB) cases and can highlight relevant issues in urban TB control in low-endemic countries. Methods: A medium-sized molecular cluster of TB cases with identical DNA fingerprints was used for the development of a visual presentation of epidemiologic links between cases. Results: Of 32 cases, 17 (53%) were linked to the index case, and 11 (34%) to a secondary case. The remaining four (13%) could not be linked and were classified as possibly caused by the index patient. Of the 21 cases related to the index case, TB developed within one year of the index diagnosis in 11 patients (52%), within one to two years in four patients (19%), and within two to five years in six patients (29%). Conclusion: Cluster analysis underscored several issues for TB control in an urban setting, such as the recognition of the outbreak, the importance of reinfections, the impact of delayed diagnosis, the contribution of pub-related transmissions and its value for decision-making to extend contact investigations. Visualising cases in a cluster diagram was particularly useful in finding transmission locations and the similarities and links between patients.
KW - classification
KW - diagnosis
KW - DNA fingerprinting
KW - genotypes
KW - human diseases
KW - infections
KW - infectious diseases
KW - outbreaks
KW - reinfection
KW - tuberculosis
KW - urban areas
KW - man
KW - Mycobacterium
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterium
KW - communicable diseases
KW - delayed diagnosis
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093284457&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2334/9/151
UR - email: devriesg@ggd.rotterdam.nl\vanhestr@ggd.rotterdam.nl\burdo_c@hotmail.com\Dick.van.Soolingen@rivm.nl\j.richardus@erasmusmc.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Shelter-based convalescence for homeless adults in Amsterdam: a descriptive study.
AU - Laere, I. van
AU - Wit, M. de
AU - Klazinga, N.
JO - BMC Health Services Research
JF - BMC Health Services Research
Y1 - 2009///
VL - 9
IS - 208
SP - (18 November 2009)
EP - (18 November 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1472-6963
AD - Laere, I. van: Dr Valckenier Outreach Practice for Homeless People, GGD Municipal Public Health Service, PO Box 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20103001406. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Public Health
N2 - Background: Adequate support for homeless populations includes shelter and care to recuperate from illness and/or injury. This is a descriptive analysis of diagnoses and use of shelter-based convalescence in a cohort of homeless adults in Amsterdam. Methods: Demographics of ill homeless adults, diagnoses, referral pattern, length of stay, discharge locations, and mortality, were collected by treating physicians during outreach care provision in a shelter-based convalescence care facility in Amsterdam, from January 2001 through October 2007. Results: 629 individuals accounted for 889 admissions to the convalescence care facility. 83% were male and 53% were born in the Netherlands. The mean age was 45 years (SD 10 years). The primary physical problems were skin disorders (37%), respiratory disorders (33%), digestive disorders (24%) and musculoskeletal disorders (21%). Common chronic conditions included addictions 78%, mental health disorders 20%, HIV/AIDS 11% and liver cirrhosis 5%. Referral sources were self-referred (18%), general hospitals (21%) and drug clinics (27%). The median length of stay was 20 days. After (self)discharge, 63% went back to the previous circumstances, 10% obtained housing, and 23% went to a medical or nursing setting. By March 2008, one in seven users (n=83; 13%) were known to have died, the Standard Mortality Ratio was 7.5 (95% CI: 4.1-13.5). Over the years, fewer men were admitted, with significantly more self neglect, personality disorders and cocaine use. Lengths of stay increased significantly during the study period. Conclusion: Over the last years, the shelter-based convalescence care facility users were mainly homeless single males, around 45 years of age, with chronic problems due to substance use, mental health disorders and a frail physical condition, many of whom died a premature death. The facility has been flexible and responsive to the needs of the users and services available.
KW - adults
KW - chronic course
KW - health care
KW - health services
KW - homeless people
KW - human diseases
KW - social welfare
KW - Netherlands
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103001406&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1472-6963/9/208
UR - email: ivlaere@ggd.amsterdam.nl\mdwit@ggd.amsterdam.nl\n.s.klazinga@amc.uva.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effects of a short individually tailored counselling session for HIV prevention in gay and bisexual men receiving Hepatitis B vaccination.
AU - Wolfers, M. E. G.
AU - Wit, J. B. F. de
AU - Hospers, H. J.
AU - Richardus, J. H.
AU - Zwart, O. de
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2009///
VL - 9
IS - 255
SP - (21 July 2009)
EP - (21 July 2009)
CY - London; UK
PB - BioMed Central Ltd
SN - 1471-2458
AD - Wolfers, M. E. G.: Division of Infectious Diseases Control, Municipal Public Health Service Rotterdam Area, Rotterdam, Netherlands.
N1 - Accession Number: 20093243843. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - Background: There is currently a trend towards unsafe unprotected anal intercourse (UAI) among men who have sex with men. We evaluated a short individual counselling session on reducing UAI among gay and bisexual men. Methods: A quasi-experimental design was used to evaluate the counselling session. This session was conducted during consulting hours at four municipal health clinics during a Hepatitis B vaccination campaign. These clinics offered free vaccination to high-risk groups, such as gay and bisexual men. All gay and bisexual men attending health clinics in four cities in the Netherlands were asked to participate. Each participant in the intervention group received a fifteen-minute individual counselling based on the Theory of Planned Behaviour and Motivational Interviewing. Changes in UAI were measured over a 5-months period, using self-administered questionnaires. UAI was measured separately for receptive and insertive intercourse in steady and casual partners. These measures were combined in an index-score (range 0-8). Results: While UAI in the counselling group remained stable, it increased in the controls by 66% from 0.41 to 0.68. The results show that the intervention had a protective effect on sexual behaviour with steady partners. Intervention effects were strongest within steady relationships, especially for men whose steady-relationship status changed during the study. The intervention was well accepted among the target group. Conclusion: The fifteen-minute individually tailored counselling session was not only well accepted but also had a protective effect on risk behaviour after a follow-up of six months.
KW - acquired immune deficiency syndrome
KW - bisexuality
KW - hepatitis B
KW - HIV infections
KW - homosexuality
KW - human diseases
KW - Human immunodeficiency viruses
KW - immunization
KW - men
KW - sexual partners
KW - vaccination
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - AIDS
KW - bisexuals
KW - homosexuals
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093243843&site=ehost-live&scope=site
UR - http://www.biomedcentral.com/1471-2458/9/255
UR - email: wolfersm@ggd.rotterdam.nl\j.dewit@uu.nl\H.Hospers@psychology.Unimaas.nl\richardush@ggd.rotterdam.nl\dezwarto@ggd.rottdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Investigation into the effect of an alcohol-based hand product on infection rate in a nursing home setting.
AU - Roberts, C.
AU - Roberts, J.
AU - Roberts, R. J.
JO - Journal of Infection Prevention
JF - Journal of Infection Prevention
Y1 - 2009///
VL - 10
IS - 4
SP - 138
EP - 142
CY - London; UK
PB - Sage Publications Ltd
SN - 1757-1774
AD - Roberts, C.: North Wales Health Protection Team, National Public Health Service for Wales, Wales, UK.
N1 - Accession Number: 20093206832. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - The study assessed the impact on nursing home (NH) resident infection rates of providing staff with a personal alcohol-based hand product (ABHP) with and without training on its use. Fifteen North Wales NHs were recruited and randomly allocated into one of three groups. All monitored infection rates throughout the study period of 18 weeks (Phase I [weeks 1-9], Phase II [weeks 11-19]). NHs used liquid soap and water for hand washing throughout the study. Groups B and C introduced interventions during week ten: Group B were provided with personal ABHPs without training on use; Group C personal ABHPs with standard training from the sponsoring hand hygiene company. Infection rates between groups and pre- and post-intervention were compared. Infection rates (per 1,000 bed days) for Phase I vs. Phase II of the study were: Group A: 6.99 vs. 7.16; Group B: 6.08 vs. 3.46; and Group C: 5.04 vs. 6.78 respectively. Change in infection rates in Groups B and C pre- and post-intervention did not reach statistical significance, p=0.097 and p=0.072 respectively. Comparison of rates in non-intervention Group A with the intervention groups indicated a significantly lower rate after the intervention in Group B (p=0.035) but not Group C (p=0.765). Findings are limited due to sample size; introduction of personal ABHPs with training did not reduce infection rates. This conflicts with other studies examining education and improvement of hand hygiene compliance. However, infection rates fell in NHs not receiving training, possibly mediated through a sense of 'ownership' of the intervention.
KW - disease transmission
KW - disinfectants
KW - elderly
KW - health care workers
KW - health protection
KW - human diseases
KW - hygiene
KW - infectious diseases
KW - nursing homes
KW - training
KW - UK
KW - Wales
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - aged
KW - Britain
KW - communicable diseases
KW - elderly people
KW - older adults
KW - senior citizens
KW - United Kingdom
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093206832&site=ehost-live&scope=site
UR - http://bji.sagepub.com/
UR - email: carol.roberts@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A revised conversion factor relating respirable dust concentrations measured by 10 mm Dorr-Oliver nylon cyclones operated at 1.7 and 2.0 L min-1.
AU - Page, S. J.
AU - Volkwein, J. C.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2009///
VL - 11
IS - 3
SP - 684
EP - 689
CY - Cambridge; UK
PB - Royal Society of Chemistry
SN - 1464-0325
AD - Page, S. J.: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA.
N1 - Accession Number: 20093117094. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Accurate measurement of workplace respirable dust concentration is an essential step in eliminating lung disease in any occupational setting. In the United States (U.S.) coal mining industry, this measurement process has relied upon a personal sampler that includes a 10 mm Dorr-Oliver (DO) nylon cyclone operated at a flow rate of 2.0 L min-1 to collect a respirable dust sample. Dust concentrations measured with this sampler are multiplied by 1.38, which was empirically derived, to convert them to measurements approximating the United Kingdom British Medical Research Council (BMRC) definition of respirable dust upon which the health effects of coal mine dust are based. The International Organization for Standardization (ISO) subsequently refined the respirable dust definition and the U.S. National Institute for Occupational Safety and Health (NIOSH) 1995 Criteria for a Recommended Standard presented a conversion multiplier of 0.857 to apply to the 2.0 L min-1 DO (in addition to the 1.38 multiplier) to obtain equivalent ISO concentrations, as approximated by the 1.7 L min-1 DO. However, the conversion multiplier 0.857 was derived indirectly from a limited size distribution data set rather than a direct comparison of the DO samplers. The present analysis focuses on providing a more accurate conversion multiplier derived from direct comparisons of the 2.0 L min-1 (with 1.38 BMRC equivalency multiplier) and 1.7 L min-1 DO cyclones. A weighted linear regression analysis of this database suggests that a more accurate estimate of the conversion multiplier is 0.815.
KW - dust
KW - estimation
KW - measurement
KW - occupational hazards
KW - regression analysis
KW - respiratory diseases
KW - work places
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - lung diseases
KW - metrology
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093117094&site=ehost-live&scope=site
UR - http://www.rsc.org/jem
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a database for government-funded health/functional food research.
AU - Kim JiYeon
AU - Park JuYeon
AU - Kwon Oran
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
Y1 - 2009///
VL - 12
IS - 6
SP - 1185
EP - 1189
CY - New Rochelle; USA
PB - Mary Ann Liebert, Inc.
SN - 1096-620x
AD - Kim JiYeon: Division of Nutrition and Functional Food Standards, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20103051038. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Human Nutrition; Tropical Diseases
N2 - The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaDff) has been established by the Korea Food and Drug Administration. About 200 project reports funded by government agencies from 1993 through 2007 were retrieved, using existing government-wide online databases created by the Korea Institute Science and Technology, Evaluation and Planning and the Korea Institute of Science and Technology Information. In 2008, the database was released with information regarding individual projects and technological achievements for individual ingredients with a vision for HFF development. Overall, government-funded HFF research has primarily involved botanicals including herbs and food plants. The immune system, oxidant stress alleviation, and the cardiovascular system are the three leading health systems being investigated. With regard to the types of studies performed, the majority were in vitro studies and animal studies with limited numbers of human intervention studies. Government funds have been fragmented for many different ingredients, and this represents a major gap in HFF development. This database is most valuable for evaluating trends in government-funded HFF research. It is also useful to identify research overlaps and gaps and to help research scientists within academia and industry identify potential sources of government funding.
KW - databases
KW - food research
KW - functional foods
KW - funding
KW - nutrition research
KW - nutritive value
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - data banks
KW - nutritional value
KW - quality for nutrition
KW - South Korea
KW - Food Science and Food Products (Human) (QQ000)
KW - Research (AA500)
KW - Information and Documentation (CC300)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103051038&site=ehost-live&scope=site
UR - http://www.liebertonline.com/jmf
UR - email: orank@ewha.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viral hepatitis in a multi-ethnic neighborhood in the Netherlands: results of a community-based study in a low prevalence country.
AU - Veldhuijzen, I. K.
AU - Driel, H. F. van
AU - Vos, D.
AU - Zwart, O. de
AU - Doornum, G. J. J. van
AU - Man, R. A. de
AU - Richardus, J. H.
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
Y1 - 2009///
VL - 13
IS - 1
SP - e9
EP - e13
CY - Oxford; UK
PB - Elsevier
SN - 1201-9712
AD - Veldhuijzen, I. K.: Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20093034456. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - Objectives: The prevalence of viral hepatitis varies worldwide. Although the prevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) infection is generally low in Western countries, pockets of higher prevalence may exist in areas with large immigrant populations. The aim of this study was to obtain further information on the prevalence of viral hepatitis in a multi-ethnic area in the Netherlands. Methods: We conducted a community-based study in a multi-ethnic neighborhood in the city of Rotterdam, the Netherlands, including both native Dutch and migrant participants, who were tested for serological markers of hepatitis A, hepatitis B, and hepatitis C infection. Results: Markers for hepatitis A infection were present in 68% of participants. The prevalence of hepatitis B core antibodies (anti-HBc), a marker for previous or current infection, was 20% (58/284). Prevalence of hepatitis A and B varied by age group and ethnicity. Two respondents (0.7%) had chronic HBV infection. The prevalence of hepatitis C was 1.1% (3/271). High levels of isolated anti-HBc were found. Conclusions: We found a high prevalence of (previous) viral hepatitis infections. This confirms previous observations in ethnic subgroups from a national general population study and illustrates the high burden of viral hepatitis in areas with large immigrant populations.
KW - epidemiology
KW - ethnic groups
KW - hepatitis A
KW - hepatitis B
KW - human diseases
KW - immigrants
KW - Netherlands
KW - Hepatitis A virus
KW - Hepatitis B virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Demography (UU200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093034456&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7CPT-4T4JDPX-1&_user=6686535&_coverDate=01%2F31%2F2009&_rdoc=18&_fmt=high&_orig=browse&_srch=doc-info(%23toc%2317975%232009%23999869998%23788128%23FLA%23display%23Volume)&_cdi=17975&_sort=d&_docanchor=&_ct=31&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=e6e450caaa25bf4fdb770306f5afff10
UR - email: veldhuijzeni@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lung disease mortality in the United States: the National Longitudinal Mortality Study.
AU - Lewis, D. R.
AU - Clegg, L. X.
AU - Johnson, N. J.
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
Y1 - 2009///
VL - 13
IS - 8
SP - 1008
EP - 1014
CY - Paris; France
PB - The International Union Against Tuberculosis and Lung Disease
SN - 1027-3719
AD - Lewis, D. R.: Surveillance Research Program, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, 6116 Executive Blvd., Room 504, MSC 8316, Bethesda, MD 20892-8316, USA.
N1 - Accession Number: 20093249904. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 35 ref. Subject Subsets: Public Health
N2 - SETTING: The National Longitudinal Mortality Study (NLMS) offers the advantage of assessing mortality in a representative population of the United States. OBJECTIVE: To evaluate health disparities associated with lung cancer and chronic obstructive pulmonary disease (COPD) mortality in the United States and whether these associations are similar between these outcomes. DESIGN: The NLMS is a prospective study. Data from NLMS cohort years 1985, 1992, 1993, 1995 and 1996 were included, representing nearly 1.5 million person-years. Lung cancer and COPD mortality relative risks (RRs) from Cox regression analysis, including residential characteristics, marital status, education, health insurance and family income, were evaluated. RESULTS: By 1998, 1273 lung cancer deaths and 772 COPD deaths occurred. Lung cancer mortality rates were approximately two times higher than COPD mortality rates among race and ethnic groups. Cox regression analysis revealed that low education (RR=1.77, significant, P=0.01) and low family income (RR=1.50, significant, P=0.01) are associated with lung cancer and COPD mortality, controlling for age, race/ethnicity, sex and smoking status. CONCLUSIONS: COPD and lung cancer mortality have similar associations with health disparity indicators in the NLMS data, with some differences in the magnitude of the effect.
KW - chronic obstructive pulmonary disease
KW - education
KW - epidemiology
KW - ethnic groups
KW - household income
KW - human diseases
KW - lung cancer
KW - lungs
KW - mortality
KW - neoplasms
KW - respiratory diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - death rate
KW - lung diseases
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093249904&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/iuatld/ijtld
UR - email: lewisde@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Early assessment of the implementation of a national programme for the prevention of mother-to-child transmission of HIV in Cameroon and the effects of staff training: a survey in 70 rural health care facilities.
AU - Labhardt, N. D.
AU - Manga, E.
AU - Ndam, M.
AU - Balo, J. R.
AU - Bischoff, A.
AU - Stoll, B.
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
Y1 - 2009///
VL - 14
IS - 3
SP - 288
EP - 293
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1360-2276
AD - Labhardt, N. D.: Office of the Surgeon General Basel-Stadt, Basel-Stadt, Switzerland.
N1 - Accession Number: 20093102108. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish. Number of References: 23 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - OBJECTIVES: To assess the availability of equipment and the staff's knowledge to prevent Mother-To-Child Transmission (PMTCT) in rural healthcare facilities recently covered by the national PMTCT programme in Cameroon. METHODS: In eight districts inventories of antiviral drugs and HIV test kits were made on site, using a standardised check-list. Knowledge of HIV and PMTCT was evaluated with a multiple-choice (MC) questionnaire based on typical clinical PMTCT cases. Staff participated subsequently in a 2-day training on HIV/AIDS and the Cameroon PMTCT guidelines. Immediately after training and after 7 months, retention of knowledge was tested with the same questions but in different order and layout. RESULTS: Sixty two peripheral nurse-led clinics and the eight district hospitals were assessed. Whereas all district hospitals presented complete equipment, only six of the peripheral clinics (10%) were equipped with both complete testing materials and a full set of drugs to provide PMTCT. Thirty six peripheral facilities (58%) possessed full equipment for HIV-testing and 8 (13%) stocked all PMTCT drugs. Of 137 nurses, 102 (74%) agreed to the two knowledge tests. Fewer than 66% knew that HIV-diagnosis requires positive results in two different types of rapid tests and only 19% chose the right recommendation on infant-feeding for HIV-positive mothers. Correct answers on drug regimens in different PMTCT settings varied from 25% to 56%. All percentages of correct answers improved greatly with training (P<0.001) and retention remained high 7 months after training (P<0.001). CONCLUSIONS: Prevent Mother-To-Child Transmission programmes in settings such as rural Cameroon need to be adapted to the special needs of peripheral nurse-led clinics. Appropriate short training may considerably improve nurses' competence in PMTCT. Other important components are regular supervision and measures to guarantee supply of equipment in rural areas.
KW - antiviral agents
KW - checklists
KW - disease transmission
KW - drug therapy
KW - effects
KW - equipment
KW - guidelines
KW - health care
KW - health centres
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - maternal transmission
KW - mothers
KW - questionnaires
KW - regimens
KW - rural areas
KW - vertical transmission
KW - Cameroon
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - ACP Countries
KW - Central Africa
KW - Africa South of Sahara
KW - Africa
KW - Developing Countries
KW - Francophone Africa
KW - chemotherapy
KW - health centers
KW - human immunodeficiency virus infections
KW - mother to child transmission
KW - recommendations
KW - test kits
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093102108&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/tmi
UR - email: niklaus.labhardt@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
AU - Schulze, T. G.
AU - Detera-Wadleigh, S. D.
AU - Akula, N.
AU - Gupta, A.
AU - Kassem, L.
AU - Steele, J.
AU - Pearl, J.
AU - Strohmaier, J.
AU - Breuer, R.
AU - Schwarz, M.
AU - Propping, P.
AU - Nöthen, M. M.
AU - Cichon, S.
AU - Schumacher, J.
AU - Rietschel, M.
AU - McMahon, F. J.
JO - Molecular Psychiatry
JF - Molecular Psychiatry
Y1 - 2009///
VL - 14
IS - 5
SP - 487
EP - 491
CY - London; UK
PB - Nature Publishing Group
SN - 1359-4184
AD - Schulze, T. G.: Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Building 35, Room 1A205, 35 Convent Drive, Bethesda, MD 20892-3719, USA.
N1 - Accession Number: 20093134131. Publication Type: Journal Article. Corporate Author: USA, NIMH Genetics Initiative Bipolar Disorder Consortium Language: English. Subject Subsets: Public Health
N2 - Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD). We first reported association between BD and the ANK3 marker rs9804190 in a genome-wide association study (GWAS) of two independent samples (Baum et al., 2008). Subsequently, a meta-analysis of GWAS data based on samples from the US and the UK reported association with a different ANK3 marker, rs10994336 (Ferreira et al., 2008). The markers lie about 340 kb apart in the gene. Here, we test both markers in additional samples and characterize the contribution of each marker to BD risk. Our previously reported findings at rs9804190, which had been based on DNA pooling, were confirmed by individual genotyping in the National Institute of Mental Health (NIMH) waves 1-4 (P=0.05; odds ratio (OR)=1.24) and German (P=0.0006; OR=1.34) samples. This association was replicated in an independent US sample known as NIMH wave 5 (466 cases, 212 controls; P=0.017; OR=1.38). A random-effects meta-analysis of all three samples was significant (P=3×10-6; OR=1.32), with no heterogeneity. Individual genotyping of rs10994336 revealed a significant association in the German sample (P=0.0001; OR=1.70), and similar ORs in the NIMH 1-4 and NIMH 5 samples that were not significant at the P<0.05 level. Meta-analysis of all three samples supported an association with rs10994336 (P=1.7×10-5; OR=1.54), again with no heterogeneity. There was little linkage disequilibrium between the two markers. Further analysis suggested that each marker contributed independently to BD, with no significant marker × marker interaction. Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity.
KW - bipolar disorder
KW - genetic factors
KW - human diseases
KW - meta-analysis
KW - molecular biology
KW - molecular genetics
KW - risk factors
KW - Germany
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - APEC countries
KW - North America
KW - America
KW - biochemical genetics
KW - manic depression
KW - United States of America
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093134131&site=ehost-live&scope=site
UR - http://www.nature.com/mp/journal/v14/n5/abs/mp2008134a.html
UR - email: schulzet@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Mumps outbreak on the Island of Anglesey, North Wales, December 2008-January 2009.
AU - Roberts, C.
AU - Porter-Jones, G.
AU - Crocker, J.
AU - Hart, J.
JO - Eurosurveillance
JF - Eurosurveillance
Y1 - 2009///
VL - 14
IS - 5
SP - 19109
EP - 19109
CY - Saint-Maurice; France
PB - Eurosurveillance
AD - Roberts, C.: North Wales Health Protection Team, National Public Health Service for Wales, Mold, Flintshire, UK.
N1 - Accession Number: 20093279879. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Public Health
N2 - Twenty-three cases of clinical mumps in young people were reported in North Wales, UK over a five-week period since 27 December 2008. Twenty of the cases had received two doses of the measles, mumps, rubella vaccine and two cases had had one dose. The only vaccinated cases was a 37-year-old patient who was too old to have been offered measles, mumps, rubella vaccine as a child. Most cases appear to be mild, with no reports to date of orchitis or other complications. MMR vaccine was introduced into the childhood vaccination programme of the United Kingdom in 1988. The mumps strain currently used in the MMR vaccine is Jeryl Lynn. However, some of the older cases (over 17 years old) in this outbreak will have received MMR vaccine containing the Urabe strain which was used in the UK from 1988 to 1992. One of the 23 cases was admitted to the district general hospital where blood for serology was taken. This was reported as negative for IgM against mumps virus, but positive for IgG with no evidence of recent infection. Another case, who is a health care worker, had paired sera taken by the Occupational Health Department, which showed a rising titre of mumps antibodies and was therefore confirmed as recent mumps infection by the regional virology laboratory. Salivary swab samples of the remaining 21 cases were submitted to the reference laboratory at the Health Protection Agency Centre for Infections at Colindale. Letters were sent to the school many of the cases attend, advising that all children should ensure that they have received two doses of MMR vaccine. Letters were also sent to general practitioners in the area alerting them to the fact that cases of mumps are occurring despite complete vaccination status, and preparing them for requests for MMR vaccination.
KW - human diseases
KW - immunization
KW - infection control
KW - measles mumps rubella vaccines
KW - mumps
KW - outbreaks
KW - vaccination
KW - UK
KW - man
KW - Mumps virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - immune sensitization
KW - United Kingdom
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093279879&site=ehost-live&scope=site
UR - http://www.eurosurveillance.org/images/dynamic/EE/V14N05/art19109.pdf
UR - email: Judy.Hart@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Verocytotoxin-producing Escherichia coli O157 outbreak in Wrexham, North Wales, July 2009.
AU - Hart, J.
AU - Smith, G.
JO - Eurosurveillance
JF - Eurosurveillance
Y1 - 2009///
VL - 14
IS - 32
SP - 19300
EP - 19300
CY - Saint-Maurice; France
PB - Eurosurveillance
AD - Hart, J.: North Wales Health Protection Team, National Public Health Service for Wales, Mold, Flintshire, UK.
N1 - Accession Number: 20093286022. Publication Type: Journal Article. Language: English. Number of References: 2 ref. Subject Subsets: Public Health
N2 - An outbreak of Escherichia coli O157 involving four people in North Wales, UK was investigated. The cases involved females, aged 3, 23, 32 and 32 years. Case 1 had an onset date of 20 July 2009 and was reported to the NPHS on 22 July after a positive faecal sample result. She later developed haemolytic uraemic syndrome and thrombocytopenic purpura and was admitted to hospital on 28 July. She is currently receiving renal dialysis and ongoing plasmapheresis. Case 2 had an onset date of 21 July and was reported to the NPHS on 24 July. She is recovering at home. Cases 3 and 4 are a mother and daughter, both with onset of symptoms on 21 July. The child was admitted to hospital on 27 July with haemolytic uraemic syndrome and required dialysis for 5 days. She has been discharged. Samples were taken from mother and child at the hospital, and the results were reported to the NPHS on 30 July. All 4 cases reported eating different products from a fast food outlet in the area. Faecal samples from all the cases were confirmed as positive for E. coli O157. Laboratory typing shows all the isolates belong to phage type 2. The food outlet was visited by Environmental Health Officers from WCBC on 30 July. Several problems were identified, such as poor food handling techniques, lack of hand washing equipment, no evidence of food hygiene training for staff and no food safety management system in place. As a precaution the outlet is currently the subject of a Hygiene Emergency Prohibition Order, and is closed until further notice.
KW - epidemiology
KW - food contamination
KW - haemolytic uraemic syndrome
KW - human diseases
KW - outbreaks
KW - thrombocytopenic purpura
KW - UK
KW - Wales
KW - Escherichia coli O157
KW - man
KW - Escherichia coli
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - food contaminants
KW - hemolytic uremic syndrome
KW - United Kingdom
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093286022&site=ehost-live&scope=site
UR - http://www.eurosurveillance.org/images/dynamic/EE/V14N32/art19300.pdf
UR - email: Judy.Hart@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Viral hepatitis among men who have sex with men, epidemiology and public health consequences.
AU - Urbanus, A. T.
AU - Houdt, R. van
AU - Laar, T. J. W. van de
AU - Coutinho, R. A.
A2 - Laar, M. J. van de
T3 - Special Issue: HIV/AIDS and other sexually transmitted infections (STI) in men who have sex with men (MSM) - trends and behavioural surveillance.
JO - Eurosurveillance
JF - Eurosurveillance
Y1 - 2009///
VL - 14
IS - 47
SP - 19421
EP - 19421
CY - Saint-Maurice; France
PB - Eurosurveillance
AD - Urbanus, A. T.: Cluster Infectious Diseases, Public Health Service, Amsterdam, Netherlands.
N1 - Accession Number: 20093352309. Publication Type: Journal Article. Note: Special Issue: HIV/AIDS and other sexually transmitted infections (STI) in men who have sex with men (MSM) - trends and behavioural surveillance. Language: English. Number of References: 52 ref. Subject Subsets: Public Health
N2 - Viral hepatitis causes major disease burden worldwide, due to the chronic hepatitis sequelae: cirrhosis and primary liver cancer. Transmission of viral hepatitis is a problem not only in low-income countries, but also in high-income ones where viral hepatitis is a frequently occurring infection among men who have sex with men (MSM). Although the transmission routes of the three main hepatitis viruses, A, B and C, differ, MSM mainly acquire viral hepatitis during sexual contact. Vaccination programmes (only available for hepatitis A and B), raising awareness, and screening can be used to prevent transmission. However, despite the introduction of such methods in many high-income countries, the spread of viral hepatitis among MSM is still ongoing. This paper provides an overview of sexually acquired hepatitis A, B, and C among MSM in high-income countries, using recent insights obtained through molecular epidemiology, with the aim to raise awareness, improve vaccination coverage, and stimulate prevention programmes.
KW - epidemiology
KW - hepatitis A
KW - hepatitis B
KW - hepatitis C
KW - homosexuality
KW - human diseases
KW - men
KW - sexually transmitted diseases
KW - viral hepatitis
KW - Hepatitis A virus
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - Hepacivirus
KW - Flaviviridae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - homosexuals
KW - STDs
KW - venereal diseases
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093352309&site=ehost-live&scope=site
UR - http://www.eurosurveillance.org/images/dynamic/EE/V14N47/art19421.pdf
UR - email: aurbanus@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Contextualization of physical and sexual assault in male prisons: incidents and their aftermath.
AU - Wolff, N.
AU - Shi, J.
JO - Journal of Correctional Health Care
JF - Journal of Correctional Health Care
Y1 - 2009///
VL - 15
IS - 1
SP - 58
EP - 77
CY - London; UK
PB - Sage Publications Ltd
SN - 1078-3458
AD - Wolff, N.: Center for Mental Health Services and Criminal Justice Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
N1 - Accession Number: 20093022190. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Physical and sexual assault are part of the prison experience. Approximately 21% of male inmates are physically assaulted during a 6-month period. Sexual assault is estimated at between 2% and 5%. Although prevalence evidence is growing, less is known about circumstances surrounding and resulting from these incidents. This article presents an analysis of approximately 2,200 physical and 200 sexual victimizations reported by a random sample of 6,964 male inmates. Physical injury occurred in 40% of physical assaults and 70% of sexual assaults between inmates and in 50% of assaults perpetrated by staff. Emotional reactions to assaults were experienced by virtually all victims. Context information is vital in the development and implementation of prevention and therapeutic interventions.
KW - aggressive behaviour
KW - behaviour
KW - correctional institutions
KW - disease prevalence
KW - emotions
KW - epidemiology
KW - men
KW - prisoners
KW - reviews
KW - sexual abuse
KW - trauma
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aggressive behavior
KW - behavior
KW - traumas
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Conflict (UU495) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093022190&site=ehost-live&scope=site
UR - http://jcx.sagepub.com/cgi/content/abstract/15/1/58
UR - email: nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Are food allergen advisory statements really warnings? Variation in consumer preferences and consumption decisions.
AU - Verrill, L.
AU - Choinière, C. J.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2009///
VL - 15
IS - 2
SP - 139
EP - 151
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1045-4446
AD - Verrill, L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093201445. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology
N2 - The authors surveyed consumers for preferences on allergen advisory statements on food labels (N=1,243). They also conducted an experiment to assess how consumers use advisory statements (N=4,049) to make food consumption decisions. Results show that food allergic individuals, including caregivers to food allergic individuals, and a control group of nonallergic people preferred "Allergen Information: May Contain..." over three other statements tested. The experiment revealed measurable differences among the statements in how they are used to make food consumption decisions. Statements rated as more believable and more helpful also received higher ratings on a "likelihood of eating/serving" measure.
KW - allergens
KW - behaviour
KW - consumer behaviour
KW - consumer information
KW - consumer preferences
KW - consumer surveys
KW - decision making
KW - food allergies
KW - food consumption
KW - labelling
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - choice
KW - consumer behavior
KW - food hypersensitivity
KW - labeling
KW - labels
KW - United States of America
KW - Food Economics (EE116) (New March 2000)
KW - Consumer Economics (EE720)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093201445&site=ehost-live&scope=site
UR - email: Linda.Verrill@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The NIOSH Retrospective Pesticide Reference Database.
AU - Ruder, A. M.
AU - Butler, M. A.
AU - Sanderson, W. T.
AU - Carreón, T.
AU - Waters, M. A.
AU - Zivkovich, Z. E.
JO - Journal of Agricultural Safety and Health
JF - Journal of Agricultural Safety and Health
Y1 - 2009///
VL - 15
IS - 2
SP - 143
EP - 156
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1074-7583
AD - Ruder, A. M.: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093140595. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Agricultural Engineering; Agricultural Entomology; Medical & Veterinary Entomology; Public Health
N2 - For the National Institute for Occupational Safety and Health (NIOSH) case-control study of glioma among non-metropolitan residents, pesticide information was considered critical. Responses to open-ended questions about pesticide exposures had to be grouped for analysis. Our aim was to classify pesticide responses in biologically relevant categories. We built the NIOSH Retrospective Pesticide Reference Database (NIOSH-RPRD) on over 1000 pesticide products and chemicals, particularly those likely to be used in the upper Midwest, using multiple sources. We obtained first and last years of product registration and product pesticide ingredients and their relative weights from the U.S. Environmental Protection Agency's Pesticide Product Information System. We added fields for pesticide class (organophosphate, etc.), carcinogenicity ratings, and evidence regarding endocrine-disrupting activity. Participant data were merged with the database, allowing each product recalled by a respondent to be linked to one or more chemicals, as appropriate. Respondents named 1,347 different pesticides (or pesticide-targeted species) used on the farm, at non-farm jobs, or at home. Database usefulness was assessed by comparing numbers of responses naming actual chemicals to total responses linked to those chemicals. Sixty percent of farm pesticide, 59% of non-farm occupational, and 65% of house and garden responses named products, not chemicals. Among farm pesticide users, 182 (46%) reported using a total of 440 pesticides 1 to 40 years (mean 8.5 years) before those pesticides actually were marketed. The NIOSH-RPRD, now available to other investigators, has been a useful tool for us and other researchers to evaluate, group, and correct pesticide responses.
KW - databases
KW - glioma
KW - neoplasms
KW - nontarget effects
KW - nontarget organisms
KW - occupational hazards
KW - organophosphorus compounds
KW - pesticide residues
KW - pesticides
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - data banks
KW - non-target organisms
KW - non-target species
KW - nontarget species
KW - organic phosphorus compounds
KW - organophosphates
KW - United States of America
KW - Information and Documentation (CC300)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093140595&site=ehost-live&scope=site
UR - http://www.asabe.org/
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Leptospira spp. and Toxoplasma gondii antibodies in vampire bats (Desmodus rotundus) in Botucatu region, SP, Brazil.
AU - Zetun, C. B.
AU - Hoffmann, J. L.
AU - Silva, R. C.
AU - Souza, L. C.
AU - Langoni, H.
JO - Journal of Venomous Animals and Toxins including Tropical Diseases
JF - Journal of Venomous Animals and Toxins including Tropical Diseases
Y1 - 2009///
VL - 15
IS - 3
SP - 546
EP - 552
CY - Botucatu; Brazil
PB - Center for the Study of Venoms and Venomous Animals CEVAP, UNESP
SN - 0104-7930
AD - Zetun, C. B.: Zoonosis Research Center, NUPEZO, Veterinary Medicine and Animal Husbandry School, São Paulo State University, UNESP, Distrito de Rubião Jr, s/n, Botucatu, SP, 18618-000, Brazil.
N1 - Accession Number: 20093283420. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Veterinary Science; Protozoology; Veterinary Science; Tropical Diseases
N2 - The destruction of natural ecosystems has caused several problems to humans and other animals; herein we investigate the close relationship among vampire bats, humans and domestic animals. Toxoplasma gondii and Leptospira spp. infections are two worldwide zoonoses that provoke serious damage to animals. To determine the prevalence of bats seropositive for toxoplasmosis and leptospirosis in the Botucatu region, 204 serum samples of vampire bats (Desmodus rotundus) were tested for T. gondii antibodies by modified agglutination test (MAT-t) and for Leptospira spp. by microscopic agglutination test (MAT-l). No animal was tested positive for T. gondii while leptospiral positivity was 7.8% for Pyrogenes, Shermani and Javanica serovars, with titers varying from 100 to 1,600. Thus, it was verified that D. rotundus does not play a relevant role in toxoplasmosis epidemiology. However, these bats can be important in the maintenance of Leptospira spp. in the environment.
KW - agglutination tests
KW - domestic animals
KW - ecosystems
KW - epidemiology
KW - infections
KW - leptospirosis
KW - livestock
KW - serological surveys
KW - seroprevalence
KW - serovars
KW - toxoplasmosis
KW - wild animals
KW - world
KW - zoonoses
KW - Brazil
KW - animals
KW - Chiroptera
KW - Desmodus
KW - Desmodus rotundus
KW - Leptospira
KW - man
KW - Toxoplasma
KW - Toxoplasma gondii
KW - eukaryotes
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Phyllostomidae
KW - Chiroptera
KW - Desmodus
KW - Leptospiraceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Sarcocystidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Toxoplasma
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - bacterium
KW - seroepidemiology
KW - vampire bats
KW - worldwide
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biological Resources (Animal) (PP710)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Ecology (General) (ZZ330)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093283420&site=ehost-live&scope=site
UR - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300014&lng=en&nrm=iso&tlng=en
UR - email: hlangoni@fmvz.unesp.br
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Bovine kobuvirus in Europe.
AU - Reuter, G.
AU - Egyed, L.
T2 - Emerging Infectious Diseases
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009///
VL - 15
IS - 5
SP - 822
EP - 823
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Reuter, G.: Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary.
N1 - Accession Number: 20093360746. Publication Type: Correspondence. Language: English. Number of References: 10 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science
N2 - In February 2002, a total of 32 faecal samples were collected from cattle (Bos taurus) in a closed herd of 870 animals in central Hungary; age groups were 1-9 days (n=6), 14-17 days (n=4), 6-7 months (n=5), and 1-7.6 years (n=17). In February 2008, twenty six more samples were collected from animals <20 days of age on this farm. On the sampling days, no diarrhoea was reported. Of the 32 samples collected in 2002, two (6.25%), from 1-year-old animals, were positive for bovine Kobuvirus; however, no Kobuvirus was found in the samples from 2008. The 2 partial 3D regions (216 nt) were genetically identical. Strain kobuvirus/bovine/Aba-Z20/2002/Hungary (FJ225406) had 89%-94% nucleotide and 96%-100% amino acid identities to the 19 known Asian bovine Kobuvirus strains in GenBank. Strain Z20 had 93% and 95% nucleotide identities to U-1 in 3D/3'-UTR (862 nt) and 3'-UTR (174 nt) regions, respectively.
KW - cattle dung
KW - diarrhoea
KW - epidemiology
KW - genetics
KW - nucleotide sequences
KW - strains
KW - viral diseases
KW - Hungary
KW - cattle
KW - Kobuvirus
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - diarrhea
KW - DNA sequences
KW - scouring
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093360746&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid/content/15/5/822.htm
UR - email: reuter.gabor@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Cryptosporidium sp. rabbit genotype, a newly identified human pathogen.
AU - Chalmers, R. M.
AU - Robinson, G.
AU - Elwin, K.
AU - Hadfield, S. J.
AU - Xiao, L. H.
AU - Ryan, U.
AU - Modha, D.
AU - Mallaghan, C.
T2 - Emerging Infectious Diseases
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009///
VL - 15
IS - 5
SP - 829
EP - 830
CY - Atlanta; USA
PB - National Center for Infectious Diseases, Centers for Disease Control and Prevention
SN - 1080-6040
AD - Chalmers, R. M.: National Public Health Service for Wales, Swansea, Wales, UK.
N1 - Accession Number: 20093360750. Publication Type: Correspondence. Language: English. Number of References: 10 ref. Subject Subsets: Protozoology; Public Health
N2 - In July 2008, an outbreak caused by Cryptosporidium rabbit genotype was linked to consumption of tap water in Northamptonshire, England. On June 23 and 24, Cryptosporidium sp. oocysts were detected by operational monitoring of treated water at a surface water treatment works. Human stool samples from 34 local laboratory-identified cases of cryptosporidiosis in the affected area were sent to the UK Cryptosporidium Reference Unit for typing. Samples from 23 cases (22 primary and 1 secondary) with rabbit genotype profiles were identified by visualization of 472-, 267-, and 109-bp bands generated by digestion with SspI. All case-patients lived in the area affected by the water supply incident and had onset dates consistent with exposure by drinking water consumption or by person-to-person spread. All 23 samples were homologous to AY120901 and AY273771. Of the other 11 samples, 6 were not confirmed by IFAT or PCR, 2 were C. hominis, 1 was C. parvum, and 2 were not typeable. Six additional persons infected with Cryptosporidium sp. rabbit genotype were identified by testing 394 stool samples that were routinely submitted for typing from diarrhoeic patients in July and August from throughout the UK. All persons had onset dates inconsistent with the affected period and were from other regions of the UK. This finding may indicate a low background level of rabbit genotype cases; however, prevalence is currently unknown. The Cryptosporidium rabbit genotype has been identified as the aetiologic agent in an outbreak of diarrhoeal disease and should be considered a human pathogen.
KW - aetiology
KW - cryptosporidiosis
KW - diarrhoea
KW - disease transmission
KW - drinking water
KW - epidemiology
KW - genotypes
KW - human diseases
KW - human faeces
KW - oocysts
KW - outbreaks
KW - pathogens
KW - surface water
KW - tap water
KW - England
KW - UK
KW - Cryptosporidium
KW - Cryptosporidium parvum
KW - man
KW - Cryptosporidiidae
KW - Eucoccidiorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cryptosporidium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Great Britain
KW - UK
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Britain
KW - causal agents
KW - Cryptosporidium hominis
KW - diarrhea
KW - etiology
KW - human feces
KW - scouring
KW - United Kingdom
KW - Water Resources (PP200)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093360750&site=ehost-live&scope=site
UR - http://www.cdc.gov/eid/content/15/5/829.htm
UR - email: rachel.chalmers@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk-based process development: the food safety objective approach.
AU - Anderson, N.
JO - Resource, Engineering & Technology for a Sustainable World
JF - Resource, Engineering & Technology for a Sustainable World
Y1 - 2009///
VL - 16
IS - 1
SP - 12
EP - 13
CY - St Joseph; USA
PB - American Society of Agricultural and Biological Engineers
SN - 1076-3333
AD - Anderson, N.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, Summit Argo, Illinois, USA.
N1 - Accession Number: 20093068889. Publication Type: Journal Article. Language: English. Subject Subsets: Agricultural Engineering
N2 - The Food Safety Objective (FSO) is an output-oriented metric that designates the maximum level of a hazard tolerated in a food at the end of the food supply chain, at the moment of consumption. FSOs are used to derive performance criteria at control measures upstream in the food supply chain to achieve a target end-point level. The three categories determining whether a process will meet the desired FSO are discussed. These are: controlling initial levels, reducing levels and preventing an increase in levels. The proper way to set the FSO and the benefits of this approach are discussed.
KW - food engineering
KW - food microbiology
KW - food safety
KW - food supply
KW - HACCP
KW - risk assessment
KW - hazard analysis critical control points
KW - Laws and Regulations (DD500)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Fermentation Technology and Industrial Microbiology (WW500) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093068889&site=ehost-live&scope=site
UR - http://www.asabe.org
UR - email: nathan.anderson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Innovations to improve OSH in the informal economy: opportunities for microfinance institutions.
AU - Rinehart, R.
AU - Ocon, R.
T3 - Healthy and safe workplaces
JO - Asian-Pacific Newsletter on Occupational Health and Safety
JF - Asian-Pacific Newsletter on Occupational Health and Safety
Y1 - 2009///
VL - 16
IS - 1
SP - 18
EP - 19
CY - Helsinki; Finland
PB - Finnish Institute of Occupational Health
SN - 1237-0843
AD - Rinehart, R.: URS, Washington Division, EG&G Technical Services, U.S. National Institute for Occupational Safety and Health (NIOSH) Contractor and Adviser to the ILO Sub-Regional Office for North Africa, Cairo, Egypt.
N1 - Accession Number: 20093195885. Publication Type: Journal Article. Note: Healthy and safe workplaces Language: English. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - This paper summarizes relevant measures and strategies to address occupational health and safety issues in microfinancing institutions, as discussed in a workshop headed by ILO.
KW - health promotion
KW - health protection
KW - informal sector
KW - occupational hazards
KW - occupational health
KW - safety at work
KW - small businesses
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - occupational safety
KW - Rural Industry and Enterprises (EE350)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093195885&site=ehost-live&scope=site
UR - http://www.ttl.fi/NR/rdonlyres/8C4D76FA-53F5-4F56-B5A8-448A697FBDC3/0/AsianPacific109.pdf
UR - email: rrinehart@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk of hepatitis B for travelers: is vaccination for all travelers really necessary?
AU - Sonder, G. J. B.
AU - Rijckevorsel, G. G. C. van
AU - Hoek, A. van den
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
Y1 - 2009///
VL - 16
IS - 1
SP - 18
EP - 22
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1195-1982
AD - Sonder, G. J. B.: Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, Netherlands.
N1 - Accession Number: 20093042778. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Tropical Diseases; Leisure, Recreation, Tourism; Public Health
N2 - Objectives. Behavioral studies in travelers suggest that 33% to 76% of all travelers to hepatitis B virus (HBV)-endemic countries are at risk for HBV infection. We study the incidence and risk factors for HBV infection in travelers. Methods. Retrospective analysis of the characteristics and risk factors of all reported acute HBV patients in Amsterdam, the Netherlands, from January 1, 1992, until December 31, 2003. Results. The estimated incidence in travelers from Amsterdam to HBV-endemic countries is 4.5/100,000 travelers. Two thirds of these patients were immigrants who lived in Amsterdam and who had visited their friends and relatives in their country of origin. In 12 years, only three Dutch short-term tourists contracted HBV while traveling, all by heterosexual contacts. Conclusions. Dutch tourists who travel to HBV-endemic countries run a very low risk of contracting HBV. Vaccination of short-term Dutch tourists is not necessary. Immigrants run a higher risk irrespective of travel or duration of travel. This group should be advised vaccination.
KW - hepatitis B
KW - human diseases
KW - international trade
KW - risk factors
KW - travel medicine
KW - vaccination
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Host Resistance and Immunity (HH600)
KW - Tourism and Travel (UU700)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093042778&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jtm
UR - email: gsonder@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improving blood-borne viral diagnosis; clinical audit of the uptake of dried blood spot testing offered by a substance misuse service.
AU - Craine, N.
AU - Parry, J.
AU - O'Toole, J.
AU - D'Arcy, S.
AU - Lyons, M.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2009///
VL - 16
IS - 3
SP - 219
EP - 222
CY - Oxford; UK
PB - Blackwell Publishing
SN - 1352-0504
AD - Craine, N.: Microbiology, National Public Health Service for Wales, Ysbyty Gwynedd, Bangor LL57 2PW, Wales, UK.
N1 - Accession Number: 20093068399. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Subject Subsets: Public Health
N2 - The diagnosis of blood-borne viral infection amongst drug injectors in Wales is limited by a poor uptake of diagnostic testing; recent research suggests that dried blood spot (DBS) sample collection, rather than venepuncture, may improve diagnostic rates. We carried out an audit of the uptake of DBS testing for hepatitis C, hepatitis B and HIV amongst drug injectors attending a substance misuse service (SMS) in the first year of DBS testing being routinely offered to clients (1 May 2007 to 30 April 2008) and compared the uptake to venepuncture testing of SMS clients in the previous year. Uptake of DBS testing for hepatitis C, hepatitis B and HIV was almost six times greater than the uptake of venepuncture testing amongst clients of the SMS in the previous year. The data are consistent with the hypothesis that DBS testing can increase the uptake of blood-borne viral testing amongst current and ex-drug injectors. We accept that part of the almost sixfold increase in diagnostic testing observed in the first year of DBS testing may be due to an increase in awareness amongst drug injectors of testing opportunities and a prioritization of testing by the SMS. Nonetheless the dramatic increase in uptake demonstrates that DBS testing is acceptable to drug injectors and should be subject to more rigorous trials to evaluate its potential impact on diagnosis.
KW - diagnosis
KW - diagnostic techniques
KW - hepatitis B
KW - hepatitis C
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - injecting drug users
KW - liver diseases
KW - risk groups
KW - specimens
KW - viral diseases
KW - viral hepatitis
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - human immunodeficiency virus infections
KW - i.v. drug abusers
KW - i.v. drug users
KW - intravenous drug users
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093068399&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jvh
UR - email: noel.craine@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model.
AU - Meseda, C. A.
AU - Mayer, A. E.
AU - Kumar, A.
AU - Garcia, A. D.
AU - Campbell, J.
AU - Listrani, P.
AU - Manischewitz, J.
AU - King, L. R.
AU - Golding, H.
AU - Merchlinsky, M.
AU - Weir, J. P.
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2009///
VL - 16
IS - 9
SP - 1261
EP - 1271
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Meseda, C. A.: Laboratory of DNA Viruses, Division of Viral Products, HFM-457, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20093315280. Publication Type: Journal Article. Language: English.
N2 - The immune response elicited by LC16m8, a candidate smallpox vaccine that was developed in Japan by cold selection during serial passage of the Lister vaccine virus in primary rabbit kidney cells, was compared to Dryvax in a mouse model. LC16m8 carries a mutation resulting in the truncation of the B5 protein, an important neutralizing target of the extracellular envelope form of vaccinia virus (EV). LC16m8 elicited a broad-spectrum immunoglobulin G (IgG) response that neutralized both EV and the intracellular mature form of vaccinia virus and provoked cell-mediated immune responses, including the activation of CD4+ and CD8+ cells, similarly to Dryvax. Mice inoculated with LC16m8 had detectable but low levels of anti-B5 IgG compared to Dryvax, but both Dryvax and LC16m8 sera neutralized vaccinia virus EV in vitro. A truncated B5 protein (~8 kDa) was expressed abundantly in LC16m8-infected cells, and both murine immune sera and human vaccinia virus immunoglobulin recognized the truncated recombinant B5 protein in antigen-specific enzyme-linked immunosorbent assays. At a high-dose intranasal challenge (100 or 250 50% lethal doses), LC16m8 and Dryvax conferred similar levels of protection against vaccinia virus strain WR postvaccination. Taken together, the results extend our current understanding of the protective immune responses elicited by LC16m8 and indicate that the relative efficacy in a mouse model rivals that of previously licensed smallpox vaccines.
KW - animal models
KW - human diseases
KW - immune response
KW - laboratory animals
KW - smallpox
KW - vaccination
KW - mice
KW - Variola virus
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Orthopoxvirus
KW - Chordopoxvirinae
KW - Poxviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - immunity reactions
KW - immunological reactions
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093315280&site=ehost-live&scope=site
UR - http://cvi.asm.org/cgi/content/abstract/16/9/1261
UR - email: clement.meseda@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of the Fc gamma receptor-dependent component of neutralization measured by anthrax toxin neutralization assays.
AU - Verma, A.
AU - Ngundi, M. M.
AU - Meade, B. D.
AU - Pascalis, R. de
AU - Elkins, K. L.
AU - Burns, D. L.
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2009///
VL - 16
IS - 10
SP - 1405
EP - 1412
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Verma, A.: Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093315299. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Anthrax toxin neutralization assays are used to measure functional antibody levels elicited by anthrax vaccines in both preclinical and clinical studies. In this study, we investigated the magnitude and molecular nature of Fc gamma (Fcγ) receptor-dependent toxin neutralization observed in commonly used forms of the anthrax toxin neutralization assay. Significantly more Fcγ receptor-dependent neutralization was observed in the J774A.1 cell-based assay than in the RAW 264.7 cell-based assay, a finding that could be due to the larger numbers of Fcγ receptors that we found on J774A.1 cells by using flow cytometry. Thus, the extent to which Fcγ receptor-dependent neutralization contributes to the total neutralization measured by the assay depends on the specific cell type utilized in the assay. Using Fcγ receptor blocking monoclonal antibodies, we found that at least three murine Fcγ receptor classes, IIB, III, and IV, can contribute to Fcγ receptor-dependent neutralization. When antibodies elicited by immunization of rabbits with protective-antigen-based anthrax vaccines were analyzed, we found that the magnitude of Fcγ receptor-dependent neutralization observed in the J774A.1 cell-based assay was dependent on the concentration of protective antigen utilized in the assay. Our results suggest that the characteristics of the antibodies analyzed in the assay (e.g., species of origin, isotype, and subclass), as well as the assay design (e.g., cell type and protective antigen concentration), could significantly influence the extent to which Fcγ receptor-dependent neutralization contributes to the total neutralization measured by anthrax toxin neutralization assays. These findings should be considered when interpreting anthrax toxin neutralization assay output.
KW - anthrax
KW - bacterial toxins
KW - human diseases
KW - vaccination
KW - vaccines
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - Toxinology (VV820) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Host Resistance and Immunity (HH600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093315299&site=ehost-live&scope=site
UR - http://cvi.asm.org/cgi/content/abstract/16/10/1405
UR - email: drusilla.burns@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development and analytical validation of an immunoassay for quantifying serum anti-pertussis toxin antibodies resulting from Bordetella pertussis infection.
AU - Menzies, S. L.
AU - Kadwad, V.
AU - Pawloski, L. C.
AU - Lin, T. L.
AU - Baughman, A. L.
AU - Martin, M.
AU - Tondella, M. L. C.
AU - Meade, B. D.
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
Y1 - 2009///
VL - 16
IS - 12
SP - 1781
EP - 1788
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 1556-6811
AD - Menzies, S. L.: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA.
N1 - Accession Number: 20103002003. Publication Type: Journal Article. Corporate Author: Pertussis Assay Working Group Language: English. Registry Number: 308067-58-5. Subject Subsets: Public Health
N2 - Adequately sensitive and specific methods to diagnose pertussis in adolescents and adults are not widely available. Currently, no Food and Drug Administration-approved diagnostic assays are available for the serodiagnosis of Bordetella pertussis. Since concentrations of B. pertussis-specific antibodies tend to be high during the later phases of disease, a simple, rapid, easily transferable serodiagnostic test was developed. This article describes test development, initial evaluation of a prototype kit enzyme-linked immunosorbent assay (ELISA) in an interlaboratory collaborative study, and analytical validation. The data presented here demonstrate that the kit met all prespecified criteria for precision, linearity, and accuracy for samples with anti-pertussis toxin (PT) immunoglobulin G (IgG) antibody concentrations in the range of 50 to 150 ELISA units (EU)/ml, the range believed to be most relevant for serodiagnosis. The assay met the precision and linearity criteria for a wider range, namely, from 50 to 200 EU/ml; however, the accuracy criterion was not met at 200 EU/ml. When the newly adopted World Health Organization International Standard for pertussis antiserum (human) reference reagent was used to evaluate accuracy, the accuracy criteria were met from 50 to 200 international units/ml. In conclusion, the IgG anti-PT ELISA met all assay validation parameters within the range considered most relevant for serodiagnosis. This ELISA was developed and analytically validated as a user-friendly kit that can be used in both qualitative and quantitative formats. The technology for producing the kit is transferable to public health laboratories.
KW - antibodies
KW - bacterial diseases
KW - diagnosis
KW - diagnostic techniques
KW - ELISA
KW - human diseases
KW - IgG
KW - immunoassay
KW - pertussis
KW - Bordetella pertussis
KW - man
KW - Bordetella
KW - Alcaligenaceae
KW - Burkholderiales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - whooping cough
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103002003&site=ehost-live&scope=site
UR - http://cvi.asm.org/cgi/content/abstract/16/12/1781
UR - email: Sandra.Menzies@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the signalling and referral system for households at risk of eviction in Amsterdam.
AU - Laere, I. van
AU - Wit, M. de
AU - Klazinga, N.
JO - Health and Social Care in the Community
JF - Health and Social Care in the Community
Y1 - 2009///
VL - 17
IS - 1
SP - 1
EP - 8
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0966-0410
AD - Laere, I. van: GGD Municipal Public Health Service - Community Mental Health Department, Dr Valckenier Outreach Practice for the Homeless, PO Box 2200, Amsterdam 1000 CE, Netherlands.
N1 - Accession Number: 20093033657. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - In Amsterdam, over 1400 households are evicted each year. We describe the results of an evaluation of the functioning of the signalling and referral system, set up for households at risk of eviction, through a qualitative and quantitative study. Interviews and questionnaires completed by employees of 12 housing associations (for rent arrears) and by employees of 13 nuisance control care networks (for nuisance), were used. Data on households with rent arrears, for which a court eviction order was requested, were collected prospectively in September and October 2003, and retrospectively on households causing nuisance and/or who were known to be evicted due to nuisance in 2001-2003. Functioning of signalling, of the 'alarm' of problems underlying rent arrears and/or nuisance, was evaluated by the extent of problems that were identified by the employees. Functioning of referral was evaluated by comparing the identified problems with the assistance contacts. For 275 households with rent arrears, housing associations reported social problems in 196 (71%), of whom 94 (48%) were in contact with social assistance, and medical problems in 62 (23%) of whom 18 (29%) were in contact with medical assistance. House visits resulted in a much higher identification of problems, and were associated with a reduced eviction risk [relative risk 0.57 (95% confidence interval: 0.43-0.75)]. For 190 nuisance households, nuisance control care networks reported social problems in 103 (54%), of which 13 (13%) were in contact with social assistance, and medical problems in 155 (82%), of which 142 (92%) were in contact with medical assistance. To prevent evictions in Amsterdam, housing associations should improve their signalling role by conducting more house visits, and they should refer more households to medical assistance. Nuisance control care networks should refer more households to social assistance. Only a systematic and integrated approach can keep more households at home.
KW - correlated responses
KW - households
KW - housing
KW - social welfare
KW - statistical analysis
KW - Netherlands
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - statistical methods
KW - Housing and Settlement (UU100)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093033657&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/hsc
UR - email: ivlaere@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Serological attraction of nontoxic egg component to staphylococcal anti-enterotoxin.
AU - Bennett, R. W.
JO - Journal of Rapid Methods and Automation in Microbiology
JF - Journal of Rapid Methods and Automation in Microbiology
Y1 - 2009///
VL - 17
IS - 2
SP - 223
EP - 232
CY - Boston; USA
PB - Blackwell Publishing
SN - 1060-3999
AD - Bennett, R. W.: U.S. Food and Drug Administration, 5100 Paint Branch, Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093168576. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Human Nutrition
N2 - Raw whole liquid and dried eggs which were purported to contain staphylococcal enterotoxin were analyzed by a number of enzyme-linked immunosorbent assay (ELISA)-based methods. The initial evaluation was to establish whether the purported positive ELISA reactions were a result of toxin-anti-enterotoxin serological activity. A secondary consideration was to determine whether the putative protein occurred in the yolk and/or white portions of the eggs. A manual polyvalent detection system, manual monovalent ELISA and an automated polyvalent enzyme-linked fluorescent immunoassay were used to investigate this component in eggs. The ELISA results were instantaneous and showed strong positive reactions (false positives) with the manual and automated polyvalent systems, suggesting nonspecific binding of the egg-reactive component to one or more staphylococcal enterotoxin antibodies. Further analysis with the monovalent ELISA showed false-positive reactions when egg extracts were tested separately for enterotoxins A-E. The putative protein from fertilized eggs had caused false-positive reactions and the eggs did not contain preformed staphylococcal enterotoxin.
KW - detection
KW - egg yolk
KW - eggs
KW - ELISA
KW - enterotoxins
KW - serology
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - enzyme linked immunosorbent assay
KW - yolk
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093168576&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jrm
UR - email: reginald.bennett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Risk management of infective diseases of allograft.
AU - Liu Bin
JO - Zhongguo Jiaoxing Waike Zazhi / Orthopedic Journal of China
JF - Zhongguo Jiaoxing Waike Zazhi / Orthopedic Journal of China
Y1 - 2009///
VL - 17
IS - 15
SP - 1164
EP - 1166
CY - Tai'an City; China
PB - Orthopedic Center
SN - 1005-8478
AD - Liu Bin: Medical Devices Center, State Food and Drug Administration, Beijing 100044, China.
N1 - Accession Number: 20093233477. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 14 ref. Subject Subsets: Tropical Diseases
KW - allografts
KW - donors
KW - human diseases
KW - inactivation
KW - infectious diseases
KW - methodology
KW - reviews
KW - risk reduction
KW - China
KW - man
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - communicable diseases
KW - methods
KW - People's Republic of China
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093233477&site=ehost-live&scope=site
UR - email: sfdacmde@sina.com.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improving the environmental controls at a homeless shelter to assist in reducing the probability of airborne transmission of Mycobacterium tuberculosis: a case study.
AU - Coffey, C. C.
AU - Hudnall, J. B.
AU - Martin, S. B., Jr.
JO - Indoor and Built Environment
JF - Indoor and Built Environment
Y1 - 2009///
VL - 18
IS - 2
SP - 168
EP - 182
CY - London; UK
PB - Sage Publications Ltd
SN - 1420-326X
AD - Coffey, C. C.: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20093118874. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - This study describes a survey of environmental controls conducted by the National Institute for Occupational Safety and Health (NIOSH) at the Salvation Army Harbor Light Center homeless shelter in the City of St. Louis, Missouri. The Missouri Department of Health and Senior Services (MO DHHS) had epidemiologically linked 19 cases of active tuberculosis (TB) to the shelter. MO DHSS requested NIOSH to determine whether improvements could be made to the environmental controls to help reduce the probability of airborne transmission of TB at the shelter. NIOSH investigators conducted thorough inspections of the shelter's air-handling units (AHUs) and evaluated airflow rates. NIOSH recommended higher efficiency filters be used in the AHUs and installation of ultraviolet lights.
KW - epidemiology
KW - hospices
KW - human diseases
KW - public health
KW - tuberculosis
KW - Missouri
KW - USA
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - bacterium
KW - disease transmissions
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093118874&site=ehost-live&scope=site
UR - http://ibe.sagepub.com/
UR - email: CCoffey@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Respiratory morbidity and medical visits associated with dampness and air-conditioning in offices and homes.
AU - Sahakian, N.
AU - Park, J. H.
AU - Cox-Ganser, J.
JO - Indoor Air
JF - Indoor Air
Y1 - 2009///
VL - 19
IS - 1
SP - 58
EP - 67
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0905-6947
AD - Sahakian, N.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, United States Public Health Service, 1095 Willowdale Road, Mailstop H2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093062581. Publication Type: Journal Article. Language: English. Number of References: 47 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - We used data from 4345 adult US residents who were part of a 2004 national random mail survey to investigate associations between dampness and air-conditioning (AC) in homes and offices, and health outcomes, sick leave due to respiratory symptoms and medical visits during the past 12 months. We identified from this group 1396 office workers employed in professional, executive, administrative, managerial or administrative support occupations. Office workers reporting home dampness had an elevated prevalence of nasal symptoms [prevalence ratio (PR)=1.4, P=0.01] and constitutional symptoms (PR=1.3, P=0.01) in the previous year. Office workers reporting workplace dampness had an elevated prevalence of sick leave attributed to respiratory symptoms (PR=1.3, P=0.04) in the previous year. Office workers with home AC were more likely to have visited a medical specialist in the previous year (PR=1.3, P=0.02). We did not find any statistically significant associations between workplace AC and any of the health outcomes. We estimated an annual cost of US$1.4 billion for excess respiratory-related sick leave among office workers with workplace dampness. Our study strengthens the evidence of a relationship between dampness and health effects, and highlights the resulting economic impact.
KW - air conditioning
KW - air quality
KW - buildings
KW - costs
KW - dwellings
KW - human diseases
KW - occupational health
KW - office workers
KW - respiratory diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - costings
KW - lung diseases
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093062581&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/ina
UR - email: nsahakian@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Primary melanomas of the esophagus and anorectum: epidemiologic comparison with melanoma of the skin.
AU - Coté, T. R.
AU - Sobin, L. H.
JO - Melanoma Research
JF - Melanoma Research
Y1 - 2009///
VL - 19
IS - 1
SP - 58
EP - 60
CY - London; UK
PB - Lippincott Williams & Wilkins
SN - 0960-8931
AD - Coté, T. R.: US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093084218. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The objective of this study was to use recently available data to describe the epidemiology of melanomas of the esophagus and the anorectum in contrast to melanoma of the skin. The methods used include descriptive epidemiology using cases reported to the Surveillance Epidemiology and End Results registry, 1973-2003. All rates were age adjusted. We found 46 759 cutaneous melanomas, 170 anorectal melanomas and 20 esophageal melanomas, corresponding to age-adjusted rates of 70.1, 0.27, and 0.03 per million population, respectively. Median age of patients with melanoma of the skin was less than those with melanoma of the anorectum or esophagus (55 years vs. 71 years and 69 years, respectively). Rates of melanoma of the skin were 1.5-fold higher for men than for women (87.1 vs. 58.1 per 106); in contrast, rates of anorectal melanoma were 1.6-fold higher for women than for men (0.324 vs. 0.199 per 106). Rates of cutaneous melanoma for whites were 13-fold higher than for blacks (80.6 vs. 6.1 per 106, P<0.001), whereas the rates of anorectal melanoma were 1.7-fold higher among whites than blacks (0.273 vs. 0.173 per 106). Comparing the period 1973-1987 with 1988-2003, the rate of cutaneous melanoma increased 1.4-fold (56.0-80.1 per 106), whereas the rate of anorectal melanoma similarly increased 1.8-fold (0.182 to 0.329 per 106). In conclusion, anorectal melanomas, and especially, esophageal melanomas remain rare malignancies. This is the first report where temporal trends in anorectal melanoma are following the increased incidence of cutaneous melanomas, but it is unclear whether immunohistochemical diagnostic practices have influenced this trend. As gastrointestinal melanomas represent melanocytic transformation in the absence of sunlight, their epidemiology may provide etiologic clues to alternative or systemic transformative factors also operant in cutaneous melanoma.
KW - anus
KW - epidemiology
KW - human diseases
KW - melanoma
KW - neoplasms
KW - oesophageal diseases
KW - oesophagus
KW - rectum
KW - skin
KW - skin diseases
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - anal diseases
KW - cancers
KW - dermatoses
KW - dermis
KW - esophageal diseases
KW - esophagus
KW - rectal disease
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093084218&site=ehost-live&scope=site
UR - http://www.melanomaresearch.com/pt/re/melres/abstract.00008390-200902000-00009.htm;jsessionid=J2PMwVr8vcwq2y6s1VwMd5nP4Y6V1Lv80zWQy4zdHzpNpV4QxzX1!-1690570675!181195629!8091!-1
UR - email: timothy.cote@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for serious mental illness in the National Survey on Drug Use and Health (NSDUH).
AU - Colpe, L. J.
AU - Epstein, J. F.
AU - Barker, P. R.
AU - Gfroerer, J. C.
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2009///
VL - 19
IS - 3
SP - 210
EP - 211
CY - New York; USA
PB - Elsevier
SN - 1047-2797
AD - Colpe, L. J.: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1039, Rockville, MD 20857, USA.
N1 - Accession Number: 20093103169. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Subject Subsets: Public Health
N2 - In 2004, a separate module to estimate the lifetime and 12-month prevalence of major depressive episode (MDE) was added to the NSDUH questionnaire. To preserve space in the survey, the extra mental health and impairment scales that were not used to estimate serious mental illness (SMI) was removed. A split sample experimented was embedded within the 2004 NSDUH (USA) to measure how the removal of the extra scales would impact overall SMI estimates. Half of the adult sample (n=22 628) was administered the mental health module used in the 2003 NSDUH questionnaire and the other half (n=22 825) was administered the revised module. The results showed large differences within the 2 samples in both the K6 total score and the proportion of respondents with a K6 score above the SMI cutpoint. A full report detailing the findings of the study may be found at http://oas.samhsa.gov/nsduh/2k4MRB/2k4spd.pdf.
KW - human diseases
KW - mental disorders
KW - questionnaires
KW - screening
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - mental illness
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093103169&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/10472797
UR - email: Lisa.Colpe@SAMHSA.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Surveillance of fungal allergic sensitization using the fluorescent halogen immunoassay.
AU - Green, B. J.
AU - Tovey, E. R.
AU - Beezhold, D. H.
AU - Perzanowski, M. S.
AU - Acosta, L. M.
AU - Divjan, A. I.
AU - Chew, G. L.
JO - Journal de Mycologie Médicale
JF - Journal de Mycologie Médicale
Y1 - 2009///
VL - 19
IS - 4
SP - 253
EP - 261
CY - Paris; France
PB - Elsevier Masson
SN - 1156-5233
AD - Green, B. J.: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095, Willowdale Road, M.S. 4020, Morgantown, WV 26505-2888, USA.
N1 - Accession Number: 20103028817. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 54 ref. Subject Subsets: Public Health; Medical & Veterinary Mycology
N2 - Objective. - Conidia derived from a small number of common fungal genera are widely accepted as the etiological agents responsible for fungal allergic sensitization. The contribution of fungal conidia, spores, airborne hyphae, and subcellular fragments from other uncharacterized fungal genera remains unclear. In this proof-of-concept study, we examined the composition of mycoaerosols that atopic women were exposed and sensitized to in their own indoor environment using the fluorescent halogen immunoassay (fHIA). Patients and methods. - Mycoaerosols were collected onto mixed cellulose ester protein binding membranes (PBMs) for 30 min with volumetric air sampling pumps. The PBMs were laminated with an adhesive cover slip and indirectly immunostained with individual patient serum IgE using the fHIA. Samples were examined using confocal laser scanning microscopy and immunostained particles were expressed as a percentage of total particles. Results. - All air samples contained a broad spectrum of fungal spores, conidia, hyphae, and other fungal particulates. Airborne concentrations varied between individual study participant environments. Positively immunostained conidia belonging to moniliaceous amerospores, Cladosporium, Alternaria, and many unknown species were observed in the majority of air samples. Other fungal genera including Bipolaris, Curvularia, Pithomyces, and Stachybotrys, in addition to, ascospore genera and dematiaceous hyphal fragments released detectable allergen. Twelve percent of all fHIA haloes quantified in the analysis were directed towards fungal particles. No immunostaining was detected to conidia belonging to Epicoccum, Fusarium, and Spegazzinia species. Conclusion. - In addition to characterized fungal aeroallergens, we observed a wider composition of fungi that bound human IgE. Field surveillance studies that utilize immunodiagnostic techniques such as the fHIA will provide further insight into the diversity of fungi that function as aeroallergen sources in individual study participant environments.
KW - allergens
KW - allergies
KW - atopy
KW - conidia
KW - disease surveys
KW - fungal spores
KW - halogens
KW - human diseases
KW - hyphae
KW - immunofluorescence
KW - women
KW - Alternaria
KW - Bipolaris
KW - Cladosporium
KW - Curvularia
KW - man
KW - Pithomyces
KW - Stachybotrys
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Davidiellaceae
KW - Capnodiales
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Hypocreales
KW - Sordariomycetes
KW - disease surveillance
KW - fluorescent antibody technique
KW - fungus
KW - Hyphomycetes
KW - IFAT
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103028817&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/11565233
UR - email: Brett.Green@cdc.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Asthma and respiratory symptoms in hospital workers related to dampness and biological contaminants.
AU - Cox-Ganser, J. M.
AU - Rao, C. Y.
AU - Park, J. H.
AU - Schumpert, J. C.
AU - Kreiss, K.
JO - Indoor Air
JF - Indoor Air
Y1 - 2009///
VL - 19
IS - 4
SP - 280
EP - 290
CY - Copenhagen; Denmark
PB - Blackwell Publishing
SN - 0905-6947
AD - Cox-Ganser, J. M.: Field Studies Branch, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093219848. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Medical & Veterinary Mycology; Public Health
N2 - The National Institute for Occupational Safety and Health investigated respiratory symptoms and asthma in relation to damp indoor environments in employees of two hospitals. A cluster of six work-related asthma cases from one hospital department, whose symptoms arose during a time of significant water incursions, led us to conduct a survey of respiratory health in 1171/1834 employees working in the sentinel cases hospital and a nearby hospital without known indoor environmental concerns. We carried out observational assessment of dampness, air, chair, and floor dust sampling for biological contaminants, and investigation of exposure-response associations for about 500 participants. Many participants with post-hire onset asthma reported diagnosis dates in a period of water incursions and renovations. Post-hire asthma and work-related lower respiratory symptoms were positively associated with the dampness score. Work-related lower respiratory symptoms showed monotonically increasing odds ratios with ergosterol, a marker of fungal biomass. Other fungal and bacterial indices, particle counts, cat allergen and latex allergen were associated with respiratory symptoms. Our data imply new-onset of asthma in relation to water damage, and indicate that work-related respiratory symptoms in hospital workers may be associated with diverse biological contaminants.
KW - air quality
KW - allergens
KW - allergies
KW - asthma
KW - health care workers
KW - human diseases
KW - occupational health
KW - respiratory diseases
KW - respiratory hypersensitivity
KW - USA
KW - bacteria
KW - fungi
KW - man
KW - prokaryotes
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - lung diseases
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093219848&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/ina
UR - email: Jcoxganser@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Diabetes prevalence and risk factors among ethnic minorities.
AU - Ujcic-Voortman, J. K.
AU - Schram, M. T.
AU - Jacobs-van der Bruggen, M. A.
AU - Verhoeff, A. P.
AU - Baan, C. A.
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2009///
VL - 19
IS - 5
SP - 511
EP - 515
CY - Oxford; UK
PB - Oxford University Press
SN - 1101-1262
AD - Ujcic-Voortman, J. K.: Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, P.O. Box 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20103024786. Publication Type: Journal Article. Language: English. Subject Subsets: Rural Development; Tropical Diseases
N2 - Background: Ethnic minorities living in Western societies may have a higher prevalence of diabetes. We investigated whether the prevalence of diabetes among Turkish and Moroccan migrants differs from the indigenous urban population in the Netherlands, and whether these differences can be explained by differences in risk factors. Methods: In 2004 a general health survey, stratified by ethnicity and age, was carried out among the population of Amsterdam. The current study included 375 Turkish, 314 Moroccan and 417 Dutch individuals aged 18-70 years. Participants underwent a physical examination and a health interview. Diabetes was based on self-report, the use of anti-diabetic medicine, blood glucose levels and HbA1c. Results: The prevalence of diabetes in the Amsterdam population was significantly higher in Turkish (5.6%) and Moroccan (8.0%), compared to Dutch individuals (3.1%). These differences, which were much larger after adjustment for age, were only partly explained by the lower socioeconomic status and higher frequency of obesity among ethnic minorities. The difference between Dutch and Moroccan individuals remained significant even after adjustments for multiple risk factors. The typical age of onset of diabetes in both Turks and Moroccans is respectively one and two decades younger than in the indigenous population. Conclusion: Diabetes is more prevalent among Turkish and Moroccan migrants as compared to the indigenous population. Only part of this difference can be explained by differences in demographic and lifestyle risk factors.
KW - demography
KW - diabetes
KW - ethnic groups
KW - ethnicity
KW - health
KW - human diseases
KW - incidence
KW - indigenous people
KW - migrants
KW - minorities
KW - obesity
KW - public health
KW - risk factors
KW - socioeconomic status
KW - socioeconomics
KW - surveys
KW - urban areas
KW - urban population
KW - Morocco
KW - Netherlands
KW - Turkey
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Francophone Africa
KW - Africa
KW - Maghreb
KW - North Africa
KW - Mediterranean Region
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - West Asia
KW - Asia
KW - ethnic differences
KW - ethnic minorities
KW - fatness
KW - socioeconomic aspects
KW - Demography (UU200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Physiology and Biochemistry (VV050)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103024786&site=ehost-live&scope=site
UR - http://eurpub.oxfordjournals.org/cgi/content/abstract/19/5/511
UR - email: jujcic@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The use of viral vectors in introducing genes into agricultural animal species.
AU - Modric, T.
AU - Mergia, A.
JO - Animal Biotechnology
JF - Animal Biotechnology
Y1 - 2009///
VL - 20
IS - 4
SP - 216
EP - 230
CY - Washington; USA
PB - Taylor & Francis
SN - 1049-5398
AD - Modric, T.: Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland, USA.
N1 - Accession Number: 20093285850. Publication Type: Journal Article. Language: English. Number of References: 92 ref. Subject Subsets: Agricultural Biotechnology; Poultry; Pig Science; Animal Breeding; Medical & Veterinary Entomology
N2 - The use of viral vectors is a method for introducing foreign genes into various animal species. Vectors based on retro-, adeno-, flavi-, and parvoviruses have been used for research in animal species of agricultural importance, such as chickens, quail, swine, cows, goats, sheep, fish, crustaceans, and mollusks. Viral vectors allow for efficient transgenic integration into host genome or for transient expression of the transgenic construct in somatic tissues. Because of that, viral vectors are important tools for research and potentially other biotechnology applications such as improving animal production qualities and introducing disease resistance, thus improving food quality and safety. Other uses may include generating animal models of human diseases and using animals as bioreactors for production of therapeutic proteins. Each vector type provides a unique set of advantages and limitations, which are in some cases specific to an animal species or a method of introduction. This article discusses viral vector characteristics and potential applications in agriculturally important animal species. It discusses advantages and disadvantages of using viral vectors in genetic engineering of agricultural animals.
KW - animal models
KW - animal production
KW - biotechnology
KW - disease resistance
KW - food quality
KW - food safety
KW - gene expression
KW - gene transfer
KW - genes
KW - genetic engineering
KW - genetic vectors
KW - genetically engineered organisms
KW - genomes
KW - poultry
KW - transgenic animals
KW - Adenoviridae
KW - cattle
KW - Crustacea
KW - fishes
KW - Flavivirus
KW - fowls
KW - goats
KW - Mollusca
KW - Parvovirus
KW - pigs
KW - quails
KW - Retroviridae
KW - sheep
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - arthropods
KW - invertebrates
KW - aquatic organisms
KW - aquatic animals
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Capra
KW - Parvoviridae
KW - ssDNA viruses
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Coturnix
KW - RNA Reverse Transcribing Viruses
KW - Ovis
KW - chickens
KW - cloning vectors
KW - domesticated birds
KW - genetic manipulation
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - hogs
KW - resistance to disease
KW - swine
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093285850&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~db=all~content=a915549375
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Selenium content in representative Korean foods.
AU - Choi YounJu
AU - Kim JiYung
AU - Lee HaengShin
AU - Kim ChoIl
AU - Hwang InKyeong
AU - Park HyeKyung
AU - Oh ChangHwan
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2009///
VL - 22
IS - 2
SP - 117
EP - 122
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Choi YounJu: Korea Food and Drug Administration, The Bureau of Risk Management, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20093106935. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 7782-49-2. Subject Subsets: Tropical Diseases; Human Nutrition
N2 - This study was conducted to create a selenium database for the representative food items in Korean diet and to estimate the dietary selenium intake of Koreans. Three samples for each food item selected based on the result of the Korea National Health and Nutrition Examination Survey II (KNHANES II) were purchased in markets with a nationwide distribution channel and some local retail stores. Each pooled sample was analyzed in triplicate by ICP-MS after thorough homogenization. The rich sources of selenium were fish, shellfish and their products (0.152-0.788 µg/g), eggs (0.267 µg/g), and meats and poultry (0.043-0.324 µg/g). Vegetables and fruits contained trace amounts of selenium (trace-0.052 µg/g). The major food sources of selenium intake were grains and cereals (34%), fish and shellfish (21%) and meats and poultry (20%). The selenium intake of the Korean population was estimated by combining the selenium contents of frequently consumed foods in KNHANES II, of which the data was collected by 24-h recall method. The estimated and mean intake values reported for Koreans were 57.5 µg/person/day.
KW - cereals
KW - eggs
KW - fish
KW - fruits
KW - meat
KW - nutrient intake
KW - selenium
KW - shellfish
KW - vegetables
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - South Korea
KW - vegetable crops
KW - Diet Studies (VV110)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093106935&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: och35@semyung.ac.kr\changhwan@hanmail.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - U.S. Food and Drug Administration on modernization of the Nutrition and Supplements Facts labels.
AU - Trumbo, P.
AU - Shimakawa, T.
A2 - Champagne, C. M.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2009///
VL - 22
SP - S13
EP - S18
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Trumbo, P.: US Food and Drug Administration, 5100 Paint Branch Parkway, HFS 830, College Park, MD 20740, USA.
N1 - Accession Number: 20103021141. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - The U.S. Food and Drug Administration (FDA) issued an Advance Notice of Proposed Rulemaking (ANPRM) for obtaining public comments on modernizing the Nutrition and Supplements Facts label. Public comments to specific questions asked in the ANPRM will be considered by FDA for future rulemaking. There are numerous issues that FDA will consider during the rulemaking process, such as determining (1) which Dietary Reference Intakes (DRIs) to use for setting the Daily Values (DVs), (2) the approach for setting a single nutrient DV for adults and children over the age of 4 years, (3) which vitamins and minerals are of public health concern in the United States and therefore required to be declared in the Nutrition Facts label, (4) the definition of certain nutrients, such as total carbohydrate and fiber, (5) the labeling of trans fat, and (6) the use of International Units (IUs) for providing the amount of a vitamin. After reviewing the public comments, as well as any other new relevant information, FDA will publish a proposed rule in the Federal Register that provides the agency's proposed decisions for modernizing the Nutrition and Supplements Facts label. Publication of a final rule, along with the Code of Federal Regulations, will set forth the new regulatory requirements for the Nutrition and Supplements Facts labels.
KW - adults
KW - carbohydrates
KW - children
KW - fibre
KW - food supplements
KW - government organizations
KW - labelling
KW - minerals
KW - nutrient intake
KW - nutrition
KW - nutrition policy
KW - public health
KW - recommended dietary allowances
KW - reviews
KW - trans fatty acids
KW - vitamins
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fiber
KW - labeling
KW - labels
KW - RDA
KW - recommended dietary intakes
KW - saccharides
KW - United States of America
KW - Agencies and Organizations (DD100)
KW - Marketing and Distribution (EE700)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103021141&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: Paula.Trumbo@FDA.HHS.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The 2006-2007 Food Label and Package Survey (FLAPS): nutrition labeling, trans fat labeling.
AU - Brandt, M.
AU - Moss, J.
AU - Ferguson, M.
A2 - Champagne, C. M.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2009///
VL - 22
SP - S74
EP - S77
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Brandt, M.: Office of Nutrition, Labeling and Dietary Supplements (HFS-830), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20103021152. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 8 ref. Subject Subsets: Human Nutrition; World Agriculture, Economics & Rural Sociology
N2 - Since the 1970s, the Center for Food Safety and Applied Nutrition at the United States (US) Food and Drug Administration (FDA) has studied product labels from the US food supply through the Food Label and Package Survey (FLAPS). The sampling frame for the latest survey, FLAPS 2006-2007, was the ACNielsen Strategic Planner food sales database. As the newest addition to the Nutrition Facts label, this latest FLAPS included trans fat and was utilized to characterize the prevalence of foods reporting trans fat information. For this survey, FDA used a new probability-based sample design to draw a list of food products. Products were purchased from retail stores across the US, and label information was recorded to create the FLAPS 2006-2007 database. Results of initial data analyses show that an estimated 96.3% of FDA-regulated processed, packaged foods have nutrition labeling, with an additional 3.7% exempt from mandatory nutrition labeling requirements. FLAPS data show that 12% of products provide a nutrient content claim about the amount of trans fat on the principal display panel, with over 75% displaying "0 g trans fat." FDA will continue to analyze FLAPS data as a tracking mechanism to monitor the market response to food label regulations and to support policy, regulatory, economic, and food safety decisions.
KW - databases
KW - food analysis
KW - food composition
KW - foods
KW - labelling
KW - nutrient content
KW - nutrition information
KW - nutrition surveys
KW - trans fatty acids
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - data banks
KW - labeling
KW - labels
KW - nutritional surveys
KW - United States of America
KW - Information and Documentation (CC300)
KW - Marketing and Distribution (EE700)
KW - Food Composition and Quality (QQ500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103021152&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: mary.brandt@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of downloadable and printable posters for nutrition information of raw fruits, vegetables, and fish.
AU - Shimakawa, T.
AU - Weingaertner, D. W.
AU - Schmit, D. M.
AU - Brandt, M. M.
A2 - Champagne, C. M.
JO - Journal of Food Composition and Analysis
JF - Journal of Food Composition and Analysis
Y1 - 2009///
VL - 22
SP - S93
EP - S98
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0889-1575
AD - Shimakawa, T.: Office of Nutrition, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-830, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20103021156. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 24 ref. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - In the United States, nutrition labeling for raw fruits, vegetables, and fish is currently voluntary. In order to encourage retail stores that sell these foods to participate in the voluntary nutrition labeling program and to be compliant with the guidelines, the United States Food and Drug Administration (FDA) has developed downloadable and printable posters containing nutrition information for the 20 most frequently consumed raw fruits, vegetables, and fish in the United States. The FDA has made the posters available on its website (http://www.cfsan.fda.gov/nutinfo.html), and has urged retail stores to download and print the posters and to display them in their stores for consumers to use in making purchase decisions. In developing these posters, FDA followed the agency's guidelines for voluntary nutrition labeling. The names and nutrition labeling values for the raw fruits, vegetables and fish are based on the updated nutrition labeling regulation published in the Federal Register on August 17, 2006, which corrected the July 25, 2006 final rule. FDA issued a Constituent Update (electronic newsletter) and contacted trade associations representing retail food stores to inform them about the posters.
KW - diffusion of information
KW - fish
KW - food composition
KW - fruits
KW - government organizations
KW - labelling
KW - nutrition education
KW - nutrition information
KW - posters
KW - raw foods
KW - vegetables
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - information dissemination
KW - labeling
KW - labels
KW - United States of America
KW - vegetable crops
KW - Agencies and Organizations (DD100)
KW - Marketing and Distribution (EE700)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Composition and Quality (QQ500)
KW - Communication and Mass Media (UU360)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103021156&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/08891575
UR - email: Tomoko.Shimakawa@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic.
AU - Urbanus, A. T.
AU - Laar, T. J. van de
AU - Stolte, I. G.
AU - Schinkel, J.
AU - Heijman, T.
AU - Coutinho, R. A.
AU - Prins, M.
JO - AIDS
JF - AIDS
Y1 - 2009///
VL - 23
IS - 12
SP - F1
EP - F7
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0269-9370
AD - Urbanus, A. T.: Cluster of Infectious Diseases, Amsterdam Public Health Service, Department of Research, P.O. Box 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20093232857. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - Background: Since 2000 outbreaks of sexually transmitted hepatitis C Virus (HCV) infections have been reported among HIV-infected men who have sex with men (MSM). We studied the prevalence and determinants of HCV-infection among MSM attending a large sexually transmitted infection (STI) clinic in the Netherlands. Methods: In 2007-2008, 3125 attendees of the STI clinic Amsterdam, including 689 MSM, participated in an anonymous biannual crosssectional survey. Participants were interviewed and screened for HIV and HCV antibodies. Additionally, all anti-HCV positive and HIV-infected individuals were tested for HCV RNA. Using phylogenetic analysis, HCV strains of the STI clinic attendees were compared with those isolated from MSM with acute HCV in 2000-2007. Determinants of HCV-infection were analysed using logistic regression. Results: Two of 532 (0.4%) HIV-negative MSM and 28 of 157 (17.8%) HIV-positive MSM were infected with HCV. Over the study period, HCV prevalence among HIV-infected MSM increased (14.6%-20.9%). Seven of 28 (25.0%) HIV/HCV coinfected MSM had acute HCV infection. Only five of 28 (17.9%) HIV/HCV coinfected MSM ever injected drugs (IDU). HIV-infection, IDU, fisting and gamma hydroxy butyrate (GHB)-use were significantly associated with HCV-infection. Phylogenetic analyses revealed a high degree of MSM-specific clustering. Conclusion: We found a high and increasing HCV prevalence in HIV-infected MSM. Though not statistically significant, this trend, and the relatively large proportion of acute infections suggest ongoing transmission of HCV in HIV-positive MSM. Regardless of IDU, rough sexual techniques and use of recreational drugs were associated with HCV-infection; phylogenetic analysis supported sexual transmission. Targeted prevention, like raising awareness and routine testing, is needed to stop the further spread among HIV-infected MSM, and to prevent possible spillover to HIV-negative MSM.
KW - acute infections
KW - antibodies
KW - concurrent infections
KW - disease prevalence
KW - epidemiology
KW - hepatitis C
KW - HIV infections
KW - homosexuality
KW - human diseases
KW - Human immunodeficiency viruses
KW - injecting drug abuse
KW - men
KW - men who have sex with men
KW - phylogeny
KW - risk factors
KW - seroprevalence
KW - sexual behaviour
KW - sexual transmission
KW - sexually transmitted diseases
KW - surveys
KW - viral diseases
KW - viral hepatitis
KW - Netherlands
KW - Hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - gamma-hydroxybutyrate
KW - homosexuals
KW - human immunodeficiency virus infections
KW - i.v. drug abuse
KW - i.v. drug use
KW - severe infections
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - STDs
KW - venereal diseases
KW - venereal transmission
KW - viral infections
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Taxonomy and Evolution (ZZ380)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093232857&site=ehost-live&scope=site
UR - http://www.AIDSonline.com
UR - email: aurbanus@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The "RTR" medical response system for nuclear and radiological mass-casualty incidents: a functional TRiage-TRansport-treatment medical response model.
AU - Hrdina, C. M.
AU - Coleman, C. N.
AU - Bogucki, S.
AU - Bader, J. L.
AU - Hayhurst, R. E.
AU - Forsha, J. D.
AU - Marcozzi, D.
AU - Yeskey, K.
AU - Knebel, A. R.
JO - Prehospital and Disaster Medicine
JF - Prehospital and Disaster Medicine
Y1 - 2009///
VL - 24
IS - 3
SP - 167
EP - 178
CY - Madison; USA
PB - World Association for Disaster and Emergency Medicine
SN - 1049-023X
AD - Hrdina, C. M.: Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Hubert H. Humphrey Building, Suite 638G, 200 Independece Avenue SW, Washington, DC 20201, USA.
N1 - Accession Number: 20093302779. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Public Health
N2 - Developing a mass-casualty medical response to the detonation of an improvised nuclear device (IND) or large radiological dispersal device (RDD) requires unique advanced planning due to the potential magnitude of the event, lack of warning, and radiation hazards. In order for medical care and resources to be collocated and matched to the requirements, a [US] Federal interagency medical response-planning group has developed a conceptual approach for responding to such nuclear and radiological incidents. The "RTR" system (comprising Radiation-specific TRiage, TReatment, TRansport sites) is designed to support medical care following a nuclear incident. Its purpose is to characterize, organize, and efficiently deploy appropriate material and personnel assets as close as physically possible to various categories of victims while preserving the safety of responders. The RTR system is not a medical triage system for individual patients. After an incident is characterized and safe perimeters are established,RTR sites should be determined in real-time that are based on the extent of destruction, environmental factors, residual radiation, available infrastructure, and transportation routes. Such RTR sites are divided into three types depending on their physical/situational relationship to the incident. The RTR1 sites are near the epicenter with residual radiation and include victims with blast injuries and other major traumatic injuries including radiation exposure; RTR2 sites are situated in relationship to the plume with varying amounts of residual radiation present, with most victims being ambulatory; and RTR3 sites are collection and transport sites with minimal or no radiation present or exposure risk and a victim population with a potential variety of injuries or radiation exposures. Medical Care sites are predetermined sites at which definitive medical care is given to those in immediate need of care. They include local/regional hospitals, medical centers, other sites such as nursing homes and outpatient clinics, nationwide expert medical centers (such as cancer or burn centers), and possible alternate care facilities such as Federal Medical Stations. Assembly Centers for displaced or evacuating persons are predetermined and spontaneous sites safely outside of the perimeter of the incident, for use by those who need no immediate medical attention or only minor assistance. Decontamination requirements are important considerations for all RTR, Medical Care, and Assembly Center sites and transport vehicles. The US Department of Health and Human Services is working on a long-term project to generate a database for potential medical care sites and assembly centers so that information is immediately available should an incident occur.
KW - emergencies
KW - exposure
KW - fallout
KW - health care
KW - health services
KW - human diseases
KW - public health
KW - radiation
KW - radioactivity
KW - trauma
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - medical care
KW - radioactive fallout
KW - traumas
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Services (UU350)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093302779&site=ehost-live&scope=site
UR - http://pdm.medicine.wisc.edu/24-3%20PDFs/hrdina.pdf
UR - email: chad.hrdina@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation and rational use of Chinese patent medicines for diabetes.
AU - Zhang Li
AU - Yang XiaoHui
JO - China Journal of Traditional Chinese Medicine and Pharmacy
JF - China Journal of Traditional Chinese Medicine and Pharmacy
Y1 - 2009///
VL - 24
IS - 10
SP - 1270
EP - 1273
CY - Beijing; China
PB - Editorial Dept. of China Journal of Traditional Medicine and Pharmacy
SN - 1673-1727
AD - Zhang Li: National Center for Drug Reevaluation, State Food and Drug Administration, Beijing 100045, China.
N1 - Accession Number: 20093280515. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 8 ref. Subject Subsets: Aromatic & Medicinal Plants; Public Health
N2 - Chinese patent medicines have unique advantages in treatment of diabetes. This article provides a comprehensive review of the classification, analysis and evaluation of the post-marketed Chinese patent medicines for diabetes and proposes that pure TCM preparations and Chinese/western compound preparations should be considered differently in regards to their clinical uses. TCM symptom-complex differentiation is the common guideline for rational use of both pure TCM preparations Chinese/western compound preparations. Moreover, the Chinese/western compound preparations should be used in accordance to the indications of the western medicine contained and strictly under the physician's instruction. Education and training of rational medication usage, basic and clinical study on post-marketed medicines are important measures to control and reduce medication risk.
KW - diabetes
KW - drug therapy
KW - evaluation
KW - health education
KW - human diseases
KW - hypoglycaemic agents
KW - medical treatment
KW - reviews
KW - traditional Chinese medicine
KW - traditional Chinese medicines
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antidiabetics
KW - chemotherapy
KW - hypoglycemic agents
KW - TCM
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093280515&site=ehost-live&scope=site
UR - email: yxh0616@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The survivability of Bacillus anthracis (Sterne strain) in processed liquid eggs.
AU - Khan, S. A.
AU - Sung, K.
AU - Nawaz, M. S.
AU - Cerniglia, C. E.
AU - Tamplin, M. L.
AU - Phillips, R. W.
AU - Kelley, L. C.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009///
VL - 26
IS - 2
SP - 123
EP - 127
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Khan, S. A.: Division of Microbiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093101934. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Registry Number: 9006-50-2. Subject Subsets: Human Nutrition
N2 - In this study, we investigated the survival and inactivation kinetics of a surrogate strain of Bacillus anthracis (Sterne strain) in whole egg (WE), egg white (EW), sugared egg yolk (YSU), and salted egg yolk (YSA) at low (-20, 0, and 5°C), moderate (15, 20, 25, 30, 35, and 40°C), and high storage temperatures (45, 50, 55, and 60°C). Outgrowth of the spores was measured as lag phase duration (LPD). Replication of vegetative cells was measured in terms of growth rate (GR) and maximum population density (MPD). Spore inactivation was recorded as inactivation rate and percent reduction in viable count. In general, spore viability decreased at low and high temperatures and increased at moderate temperatures. At 0 and 5°C, a 60-100% reduction in spore viability was seen within 2-3 weeks in WE and YSU, 0-30% in YSA, and 50-100% in EW. At -20°C, however, no drop in spore titer was observed in YSU and EW but a 20% drop in titer was seen in YSA and 50% in WE within 2-3 weeks. At high temperatures, WE, EW, and YSA produced a 20-50% drop in the spore titer within 1-4 h whereas YSU showed 100% inactivation within 0.75 h. At moderate storage temperatures, as the temperature increased from 15 to 40°C, LPD decreased from 13.5 to 0.75 h and MPD reached 0.27-2.2×109 CFU/ml in YSU and WE, respectively. Markedly lower growth was observed in YSA (LPD=24-270 h, MPD=9×105 CFU/ml) and spores were inactivated completely within 1-6 h in EW. The survivability and inactivation data of B. anthracis in liquid egg products reported in this investigation will be helpful in developing risk assessment models on food biosecurity.
KW - egg albumen
KW - egg products
KW - egg yolk
KW - eggs
KW - food
KW - growth rate
KW - inactivation
KW - kinetics
KW - models
KW - risk
KW - risk assessment
KW - spores
KW - temperature
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Bacillus
KW - bacterium
KW - egg white
KW - yolk
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Eggs and Egg Products (QQ040)
KW - Food Science and Food Products (Human) (QQ000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093101934&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: saeed.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Planning a serial dilution test with multiple dilutions.
AU - Blodgett, R. J.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009///
VL - 26
IS - 4
SP - 421
EP - 424
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Blodgett, R. J.: Food and Drug Administration, Center for Applied Nutrition and Food Safety, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093163126. Publication Type: Journal Article. Language: English. Number of References: 5 ref. Subject Subsets: Human Nutrition
N2 - The dilutions used in a serial dilution test determine which concentrations it can estimate well. Two criteria help to select how many and which dilutions to use. The first criterion is a low probability of outcomes with either all growth or all non-growth tubes at the concentrations of interest. The second criterion considers how far the estimated concentration (MPN) is likely to be from the actual concentration.
KW - foods
KW - microbiology
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093163126&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: robert.blodgett@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of the microbiological safety of salad vegetables and sauces from kebab take-away restaurants in the United Kingdom.
AU - Meldrum, R. J.
AU - Little, C. L.
AU - Sagoo, S.
AU - Mithani, V.
AU - McLauchlin, J.
AU - Pinna, E. de
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009///
VL - 26
IS - 6
SP - 573
EP - 577
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Meldrum, R. J.: National Public Health Service for Wales, Microbiology Laboratory, Llandough Hospital, Penarth, Vale of Glamorgan, CF64 2XX, UK.
N1 - Accession Number: 20093211646. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Horticultural Science; Human Nutrition
N2 - The purpose of this study was to establish the microbiological safety of salad vegetables and sauces served in kebab take-away restaurants. Comparison with published microbiological guidelines revealed that 4.7% of 1213 salad vegetable samples were of unsatisfactory microbiological quality due to Escherichia coli and/or Staphylococcus aureus levels at ≥102 cfu g-1. Another 0.3% of salad samples were of unacceptable quality due to S. aureus at ≥104 cfu g-1 (2 samples) or the presence of Salmonella Kentucky (1 sample). Cucumber was the most contaminated salad vegetable with regards to unsatisfactory levels of E. coli (6.0%) or S. aureus (4.5%). Five percent of 1208 sauce samples were of unsatisfactory microbiological quality due to E. coli, S. aureus at ≥102 cfu g-1 and/or Bacillus cereus and other Bacillus spp. at ≥104 cfu g-1. A further 0.6% of sauce samples were of unacceptable quality due to Bacillus spp. (Bacillus subtilis, Bacillus pumilus, Bacillus licheniformis) at ≥105 cfu g-1 or the presence of Salmonella Agbeni (1 sample). More samples of chilli sauce (8.7%) were of unsatisfactory or unacceptable microbiological quality than any other sauce types. The results emphasize the need for good hygiene practices in kebab take-away restaurants handling these types of ready-to-eat products.
KW - contamination
KW - foods
KW - guidelines
KW - hygiene
KW - microbiology
KW - sauces
KW - vegetables
KW - Kentucky
KW - UK
KW - USA
KW - Bacillus cereus
KW - Bacillus licheniformis
KW - Bacillus pumilus
KW - Bacillus subtilis
KW - Cereus
KW - Escherichia
KW - Escherichia coli
KW - Salmonella
KW - Staphylococcus
KW - Staphylococcus aureus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Cactaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Escherichia
KW - Staphylococcaceae
KW - Staphylococcus
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East South Central States of USA
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - European Union Countries
KW - Bacillus
KW - bacterium
KW - Britain
KW - E. coli
KW - recommendations
KW - United Kingdom
KW - United States of America
KW - vegetable crops
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Microbiology (General) (ZZ390)
KW - Crop Produce (QQ050)
KW - Food Science and Food Products (Human) (QQ000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Horticultural Crops (FF003) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093211646&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: christine.little@hpa.org.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of dehydrated storage on the survival of Francisella tularensis in infant formula.
AU - Day, J. B.
AU - Nguyen, H.
AU - Sharma, S. K.
AU - Al-Khaldi, S. F.
AU - Hao, Y. Y. D.
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009///
VL - 26
IS - 8
SP - 932
EP - 935
CY - Oxford; UK
PB - Elsevier
SN - 0740-0020
AD - Day, J. B.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093348010. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health; Dairy Science; Medical & Veterinary Entomology
N2 - Francisella tularensis is a Gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are few studies on the long-term survivability of this organism in food matrices. Infant formula has previously been implicated as a vehicle for the transmission of a variety of bacterial pathogens in infants. In this study, we investigated the survival of F. tularensis in dehydrated infant formula under various storage conditions. F. tularensis was stored for up to 12 weeks in dehydrated infant formula in an ambient air, dry or nitrogen atmosphere. Viable counts of fresh F. tularensis at 12 weeks in infant formula revealed a 4.15, 3.37 and 3.72-log decrease in ambient air, dry and nitrogen atmosphere, respectively. D-values were calculated (in weeks) as 3.99, 4.68 and 4.47 in air, dry and nitrogen atmosphere, respectively.
KW - bacterial diseases
KW - contamination
KW - dehydration
KW - digestive system
KW - food
KW - foods
KW - infant formulae
KW - infants
KW - infections
KW - microbiology
KW - pathogens
KW - research
KW - transmission
KW - tularaemia
KW - Francisella
KW - Francisella tularensis
KW - man
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Francisella
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - alimentary tract
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - gastrointestinal system
KW - infant formula
KW - infant formulas
KW - studies
KW - tularemia
KW - Human Nutrition (General) (VV100)
KW - Food Science and Food Products (Human) (QQ000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093348010&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07400020
UR - email: james.day@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging.
AU - Ackerman, L. K.
AU - Noonan, G. O.
AU - Begley, T. H.
A2 - Theobald, A.
JO - Food Additives and Contaminants A
JF - Food Additives and Contaminants A
Y1 - 2009///
VL - 26
IS - 12
SP - 1611
EP - 1618
CY - Abingdon; UK
PB - Taylor & Francis
SN - 0265-203X
AD - Ackerman, L. K.: US Food and Drug Administration (USFDA), Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.
N1 - Accession Number: 20093359531. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 30 ref. Subject Subsets: Agricultural Engineering
N2 - The ambient ionization technique direct analysis in real time (DART) was characterized and evaluated for the screening of food packaging for the presence of packaging additives using a benchtop mass spectrometer (MS). Approximate optimum conditions were determined for 13 common food-packaging additives, including plasticizers, anti-oxidants, colorants, grease-proofers, and ultraviolet light stabilizers. Method sensitivity and linearity were evaluated using solutions and characterized polymer samples. Additionally, the response of a model additive (di-ethyl-hexyl-phthalate) was examined across a range of sample positions, DART, and MS conditions (temperature, voltage and helium flow). Under optimal conditions, molecular ion (M+H+) was the major ion for most additives. Additive responses were highly sensitive to sample and DART source orientation, as well as to DART flow rates, temperatures, and MS inlet voltages, respectively. DART-MS response was neither consistently linear nor quantitative in this setting, and sensitivity varied by additive. All additives studied were rapidly identified in multiple food-packaging materials by DART-MS/MS, suggesting this technique can be used to screen food packaging rapidly. However, method sensitivity and quantitation requires further study and improvement.
KW - analytical methods
KW - antioxidants
KW - evaluation
KW - food additives
KW - food colourants
KW - food packaging
KW - identification
KW - mass spectrometry
KW - optimization
KW - packaging materials
KW - phthalates
KW - plasticizers
KW - stabilizers
KW - analytical techniques
KW - food colorants
KW - phthalic acid esters
KW - Cleaning, Grading, Handling, Storage and Transport Equipment (NN460)
KW - Food Additives (QQ130)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093359531&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/title~content=t713599661~db=all
UR - email: Luke.Ackerman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Overlapping but distinct effects of genistein and ethinyl estradiol (EE2) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies.
AU - Delclos, K. B.
AU - Weis, C. C.
AU - Bucci, T. J.
AU - Olson, G.
AU - Mellick, P.
AU - Sadovova, N.
AU - Latendresse, J. R.
AU - Thorn, B.
AU - Newbold, R. R.
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2009///
VL - 27
IS - 2
SP - 117
EP - 132
CY - New York; USA
PB - Elsevier
SN - 0890-6238
AD - Delclos, K. B.: National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093114134. Publication Type: Journal Article. Language: English. Number of References: 136 ref. Registry Number: 57-63-6, 446-72-0. Subject Subsets: Human Nutrition
N2 - Genistein and ethinyl estradiol (EE2) were examined in multigenerational reproductive and chronic toxicity studies that had different treatment intervals among generations. Sprague-Dawley rats received genistein (0, 5, 100, or 500 ppm) or EE2 (0, 2, 10, or 50 ppb) in a low phytoestrogen diet. Nonneoplastic effects in females are summarized here. Genistein at 500 ppm and EE2 at 50 ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. At the high dose, anogenital distance was subtly affected by both compounds, and a reduction in litter size was evident in genistein-treated animals. Genistein at 500 ppm induced an early onset of aberrant cycles relative to controls in the chronic studies. EE2 significantly increased the incidence of uterine lesions (atypical focal hyperplasia and squamous metaplasia). These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations.
KW - animal models
KW - ethinylestradiol
KW - female animals
KW - genistein
KW - laboratory animals
KW - oestrous cycle
KW - progeny
KW - sexual development
KW - toxicity
KW - uterus
KW - vagina
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - breeding cycle
KW - estrous cycle
KW - reproductive cycle
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093114134&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TC0-4V88FN1-2&_user=6686535&_coverDate=04%2F30%2F2009&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235156%232009%23999729997%23998083%23FLA%23display%23Volume)&_cdi=5156&_sort=d&_docanchor=&_ct=18&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=59fa4fef2fa71d25f77121a2627fa773
UR - email: barry.delclos@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adverse events after anthrax vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990-2007.
AU - Niu, M. T.
AU - Ball, R.
AU - Woo, E. J.
AU - Burwen, D. R.
AU - Knippen, M.
AU - Braun, M. M.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 2
SP - 290
EP - 297
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Niu, M. T.: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Division of Epidemiology, Vaccine Safety Branch, 1401 Rockville Pike, HFM-220, Rockville, MD 20852, USA.
N1 - Accession Number: 20093090364. Publication Type: Journal Article. Corporate Author: USA, The VAERS Working Group Language: English. Number of References: 69 ref. Subject Subsets: Public Health
N2 - During the period March 1, 1998 to January 14, 2007, approximately 6 million doses of Anthrax vaccine adsorbed (AVA) vaccine were administered. As of January 16, 2007, 4753 reports of adverse events following receipt of AVA vaccination had been submitted to the Vaccine Adverse Event Reporting System (VAERS). Taken together, reports to VAERS did not definitively link any serious unexpected risk to this vaccine, and review of death and serious reports did not show a distinctive pattern indicative of a causal relationship to AVA vaccination. Continued monitoring of VAERS and analysis of potential associations between AVA vaccination and rare, serious events is warranted.
KW - adverse effects
KW - anthrax
KW - disease incidence
KW - epidemiology
KW - human diseases
KW - immunization
KW - vaccination
KW - vaccines
KW - USA
KW - Bacillus anthracis
KW - man
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterium
KW - immune sensitization
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093090364&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: manette.niu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa.
AU - Lee, C. H.
AU - Kuo, W. C.
AU - Suresh Beri
AU - Subash Kapre
AU - Joshi, J. S.
AU - Bouveret, N.
AU - Laforce, F. M.
AU - Frasch, C. E.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 5
SP - 726
EP - 732
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Lee, C. H.: Laboratory of Bacterial Polysaccharides, HFM-428, DPAP, OVRR, Center for Biologics Evaluation and Research, FDA at NIH Campus, Building 29, Room 404, 29 Lincoln Ave., Bethesda, MD 20892, USA.
N1 - Accession Number: 20093072763. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Tropical Diseases
N2 - Periodic epidemics of group A meningococcal (Mn A) meningitis continue to occur in sub-Saharan Africa. For its prevention, a Mn A polysaccharide (PS)-tetanus toxoid (TT) conjugate vaccine was developed using reductive amination of polysaccharide aldehydes and toxoid hydrazides. In mouse immunization studies, a schedule of three bi-weekly s.c. immunizations of 0.1 or 1 µg of the conjugate (PS content) without an adjuvant induced serum antibody levels of >10,000 units/mL measured by enzyme-linked immunosorbent assay (ELISA) as compared to ~100 units/mL in PS control mice. The elicited antibodies were active in bactericidal assays using either baby rabbit or human complement (titers >1500 compared to 200 for the PS control group). The synthesis process is reproducible and scalable, and has been successfully used for manufacturing a Mn A PS-TT conjugate vaccine based on a paradigm of shared manufacturing with transfer of new technology [Jodar L, LaForce FM, Ceccarini C, Aguado T, Granoff DM. Meningococcal conjugate vaccine for Africa: a model for development of new vaccine for the poorest countries. Lancet 2003, 361:1092-4]. A phase 1 clinical trial of the manufactured Men A-TT conjugate vaccine has been successfully carried out in adults in India, and a phase 2 clinical trial in young children is currently underway in Africa.
KW - animal models
KW - antibody formation
KW - clinical trials
KW - conjugate vaccines
KW - group A meningococci
KW - immune response
KW - immunization
KW - laboratory animals
KW - meningococcal disease
KW - vaccination
KW - vaccine development
KW - Africa
KW - mice
KW - Neisseria meningitidis
KW - Neisseria
KW - Neisseriaceae
KW - Neisseriales
KW - Betaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093072763&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: robert.lee@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation.
AU - Zubkova, I.
AU - Choi, Y. H.
AU - Chang, E.
AU - Pirollo, K.
AU - Uren, T.
AU - Watanabe, H.
AU - Wells, F.
AU - Kachko, A.
AU - Krawczynski, K.
AU - Major, M. E.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 19
SP - 2594
EP - 2602
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Zubkova, I.: Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29A/Rm 1D10/HFM 448, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093135927. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Agricultural Biotechnology
N2 - A prime/boost vaccine strategy that transfects antigen-presenting cells using ligand-modified immunoliposomes to efficiently deliver plasmid DNA, followed by boosting with non-replicating recombinant adenovirus was used in chimpanzees to generate HCV-specific memory T-cells. Three chimpanzees (two vaccines, one control) were immunized with immunoliposomes complexed with DNA expressing NS3-NS5B or complexed with empty vector. Animals were boosted with adenovirus expressing NS3-NS5B, or non-recombinant adenovirus (control). Using liposome delivery we were able to obtain specific HCV responses following DNA priming in the chimpanzees. This data and mouse immunization studies confirm this as a more efficient delivery system than direct intramuscular inoculations with naked DNA. Subsequent to the adenovirus boost significant increases in peripheral HCV-specific T-cell responses and intrahepatic IFN-γ and CD3 mRNA were also observed in the two vaccinated animals. Following challenge (100 CID50) both vaccinated animals showed immediate and significant control of viral replication (peak titers 3.7×104 and 9×103 IU/mL at weeks 1 and 2), which coincided with increases in HCV-specific T-cell responses. Viral kinetics in the control animal were comparable to historical controls with exponential increases in titer during the first several weeks. One vaccinated animal developed a low-level persistent infection (2×103 IU/mL) which correlated with a decrease in HCV-specific T-cell responses. Circulating virus isolated from both vaccinated animals showed ~2-fold greater nonsynonymous mutation rates compared to controls and the nonsynonymous/synonymous mutation rate ratio was indicative of positive selection. These data suggest that although T-cell vaccines can induce immune responses capable of controlling HCV, they also induce high levels of immune pressure for the potential selection of escape mutants.
KW - animal models
KW - hepatitis C
KW - human diseases
KW - immune response
KW - immunization
KW - laboratory animals
KW - mutations
KW - T lymphocytes
KW - transgenics
KW - vaccination
KW - chimpanzees
KW - Hepatitis C virus
KW - man
KW - Pan
KW - Pongidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093135927&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: marian.major@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatitis B vaccination targeted at behavioural risk groups in the Netherlands: does it work?
AU - Houdt, R. van
AU - Koedijk, F. D. H.
AU - Bruisten, S. M.
AU - Coul, E. L. M. O. de
AU - Heijnen, M. L. A.
AU - Waldhober, Q.
AU - Veldhuijzen, I. K.
AU - Richardus, J. H.
AU - Schutten, M.
AU - Doornum, G. J. J. van
AU - Man, R. A. de
AU - Hahné, S. J.
AU - Coutinho, R. A.
AU - Boot, H. J.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 27
SP - 3530
EP - 3535
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Houdt, R. van: Public Health Service, Department of Infectious Diseases, Amsterdam, Netherlands.
N1 - Accession Number: 20093179762. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Public Health
N2 - In November 2002, the Netherlands adopted a vaccination program targeted at behavioural risk groups. Between January 2003 and December 2007, 1386 patients acutely infected with HBV were reported. Reported cases declined from 326 in 2003 to 220 in 2007. Sexual intercourse was the most frequently reported mode of transmission (65%), especially among men having sex with men. Genotypes A and D remained predominant. In total, 40,600 participants were fully vaccinated, the overall compliance was 62%, and the estimated overall program coverage was 12% of the at-risk population. With more effort, more susceptibles may be reached, but the program will not be sufficient to substantially reduce HBV in the Netherlands. Therefore, universal vaccination should be considered.
KW - disease prevention
KW - disease transmission
KW - hepatitis B
KW - homosexual transmission
KW - homosexuality
KW - human diseases
KW - immunization
KW - men
KW - risk groups
KW - sexually transmitted diseases
KW - vaccination
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - homosexuals
KW - immune sensitization
KW - STDs
KW - venereal diseases
KW - Host Resistance and Immunity (HH600)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093179762&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: hein.boot@rivm.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence.
AU - Sauder, C. J.
AU - Zhang, C. X.
AU - Link, M. A.
AU - Duprex, W. P.
AU - Carbone, K. M.
AU - Rubin, S. A.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 42
SP - 5822
EP - 5829
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Sauder, C. J.: DVP/Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093288320. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Registry Number: 56-86-0, 56-87-1, 9001-67-6.
N2 - The recent global resurgence of mumps has drawn attention to the continued need for robust mumps immunization programs. Unfortunately, some vaccines derived from inadequately attenuated vaccine strains of mumps virus have caused meningitis in vaccinees, leading to withdrawal of certain vaccine strains from the market, public resistance to vaccination, or in some cases, cessation of national mumps vaccination programs. The most widely implicated mumps vaccine in cases of postvaccination meningitis is derived from the Urabe AM9 strain, which remains in use in some countries. The Urabe AM9 vaccine virus has been shown to exhibit a considerable degree of nucleotide and amino acid heterogeneity. Some studies have specifically implicated variants containing a lysine residue at amino acid position 335 in the hemagglutinin-neuraminidase (HN) protein with neurotoxicity, whereas a glutamic acid residue at this position was associated with attenuation. To test this hypothesis we generated two modified Urabe AM9 cDNA clones coding either for a lysine or a glutamic acid at position 335 in the HN gene. The two viruses were rescued by reverse genetics and characterized in vitro and in vivo. Both viruses exhibited similar growth kinetics in neuronal and non-neuronal cell lines and were of similar neurotoxicity when tested in rats, suggesting that amino acid 335 is not a crucial determinant of Urabe AM9 growth or neurovirulence.
KW - adverse effects
KW - amino acid sequences
KW - genes
KW - glutamic acid
KW - immunization
KW - in vitro
KW - laboratory animals
KW - lysine
KW - meningitis
KW - molecular genetics
KW - mumps
KW - neurons
KW - neurotoxicity
KW - pathogenesis
KW - sialidase
KW - vaccination
KW - vaccines
KW - viral haemagglutinins
KW - viral proteins
KW - virulence
KW - virulence factors
KW - Mumps virus
KW - rats
KW - Rubulavirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - biochemical genetics
KW - exo-alpha-sialidase
KW - immune sensitization
KW - nerve cells
KW - neuraminidase
KW - neurones
KW - protein sequences
KW - viral hemagglutinins
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093288320&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: christian.sauder@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses.
AU - Price, G. E.
AU - Soboleski, M. R.
AU - Lo, C. Y.
AU - Misplon, J. A.
AU - Pappas, C.
AU - Houser, K. V.
AU - Tumpey, T. M.
AU - Epstein, S. L.
JO - Vaccine
JF - Vaccine
Y1 - 2009///
VL - 27
IS - 47
SP - 6512
EP - 6521
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0264-410X
AD - Price, G. E.: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
N1 - Accession Number: 20093354387. Publication Type: Journal Article. Language: English. Number of References: 48 ref.
N2 - Immunization against conserved virus components induces broad, heterosubtypic protection against diverse influenza A viruses, providing a strategy for controlling unexpected outbreaks or pandemics until strain-matched vaccines become available. This study characterized immunization to nucleoprotein (NP) and matrix 2 (M2) by DNA priming followed by parenteral or mucosal boosting in mice and ferrets. DNA vaccination followed by boosting with antigen-matched recombinant adenovirus (rAd) or cold-adapted (ca) influenza virus provided robust protection against virulent H1N1 and H5N1 challenges. Compared to other boosts, mucosal rAd induced stronger IgA responses, more virus-specific activated T-cells in the lung, and better protection against morbidity following challenge even eight months post-boost. In ferrets, both mucosal and parenteral rAd boosting protected from lethal H5N1 challenge. These findings demonstrate potent protection by vaccination highly focused on conserved antigens and identify immune response measures in mice that differed among vaccinations and correlated with outcome.
KW - antigens
KW - disease models
KW - DNA vaccines
KW - experimental infections
KW - IgA
KW - immune response
KW - immunity
KW - immunization
KW - influenza A
KW - laboratory animals
KW - lungs
KW - matrix proteins
KW - nucleoproteins
KW - T lymphocytes
KW - vaccination
KW - ferrets
KW - Influenza A virus
KW - mice
KW - Mustela
KW - Mustelidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Muridae
KW - rodents
KW - antigenicity
KW - H1N1 subtype influenza A virus
KW - H5N1 subtype influenza A virus
KW - immune sensitization
KW - immunity reactions
KW - immunogens
KW - immunological reactions
KW - T cells
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093354387&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/0264410X
UR - email: suzanne.epstein@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quality assurance and safety of herbal dietary supplements.
AU - Fu, P. P.
AU - Chiang HsiuMei
AU - Xia, Q. S.
AU - Chen, T.
AU - Chen BaiHsiun
AU - Yin, J. J.
AU - Wen KuoChing
AU - Lin Ge
AU - Yu, H. T.
JO - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2009///
VL - 27
IS - 1/4
SP - 91
EP - 119
CY - Philadelphia; USA
PB - Taylor & Francis Group
SN - 1059-0501
AD - Fu, P. P.: National Center for Toxicological Research, Jefferson, Arkansas, USA.
N1 - Accession Number: 20103049338. Publication Type: Journal Article. Language: English. Number of References: 119 ref. Subject Subsets: Human Nutrition; Public Health; Postharvest Research; Aromatic & Medicinal Plants
N2 - Since the U.S. Congress passed the Dietary Supplement Health and Education Act (DSHEA) in 1994, use of herbal products has been growing rapidly worldwide. To ensure consumer health protection, the quality and safety of herbal plants, particularly those used for dietary supplement preparations, must be determined. To date, toxicological data on the identification of genotoxic and tumorigenic ingredients in many raw herbs and their mechanisms of action are lacking. Thus, identification of carcinogenic components in herbal plants is timely and important. In this review, the issues of quality control and safety evaluation of raw herbs and herbal dietary supplements are discussed. Two examples of tumorigenicity and mechanism of tumor induction are discussed: aristolochic acid and riddelliine, both of which have been detected in Chinese herbal plants. It is proposed that an organized effort with international participation on cancer risk assessment should be actively pursued so that the safety of commercial herbal plants and herbal dietary supplements can be ensured.
KW - adulteration
KW - carcinogens
KW - contamination
KW - food safety
KW - food supplements
KW - human diseases
KW - medicinal plants
KW - neoplasms
KW - quality controls
KW - reviews
KW - toxicology
KW - traditional Chinese medicines
KW - Ginkgo biloba
KW - Ginkgo
KW - Ginkgoaceae
KW - Ginkgoopsida
KW - gymnosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - aristolochic acid I
KW - cancers
KW - drug plants
KW - ginkgo tree
KW - maidenhair tree
KW - medicinal herbs
KW - officinal plants
KW - quality assurance
KW - riddelliine
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103049338&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=107845
UR - email: peter.fu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Biotransformation of acridine by Mycobacterium vanbaalenii.
AU - Sutherland, J. B.
AU - Heinze, T. M.
AU - Pearce, M. G.
AU - Deck, J.
AU - Williams, A. J.
AU - Freeman, J. P.
JO - Environmental Toxicology and Chemistry
JF - Environmental Toxicology and Chemistry
Y1 - 2009///
VL - 28
IS - 1
SP - 61
EP - 64
CY - Pensacola; USA
PB - Society of Environmental Toxicology and Chemistry (SETAC)
SN - 0730-7268
AD - Sutherland, J. B.: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093115628. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Human Nutrition
N2 - Cultures of Mycobacterium vanbaalenii strain PYR-1 in a liquid medium were exposed to the toxic environmental contaminant acridine (260 µM). After incubation for 7 d, the cultures were extracted with ethyl acetate. Metabolites were purified using high-performance liquid chromatography and analyzed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. Four metabolites, 9,10-dihydroacridine, 4-hydroxyacridine, acridine cis-1,2-dihydrodiol, and acridin-9(10H)-one, were identified.
KW - acridines
KW - contaminants
KW - heterocyclic nitrogen compounds
KW - pollutants
KW - transformation
KW - Mycobacterium
KW - Mycobacterium vanbaalenii
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Mycobacterium
KW - bacterium
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Biodegradation (XX700)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093115628&site=ehost-live&scope=site
UR - http://www.setac.org
UR - email: john.sutherland@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Dengue fever and dengue hemorrhagic fever.
AU - Morens, D. M.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2009///
VL - 28
IS - 7
SP - 635
EP - 636
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Morens, D. M.: CAPT, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
N1 - Accession Number: 20093227169. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Tropical Diseases; Public Health; Medical & Veterinary Entomology
N2 - This paper reviews the epidemiology, clinical picture, pathogenesis, diagnosis, treatment and prevention of dengue and dengue haemorrhagic fever/dengue shock syndrome.
KW - clinical aspects
KW - dengue
KW - dengue haemorrhagic fever
KW - dengue shock syndrome
KW - diagnosis
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - medical treatment
KW - pathogenesis
KW - reviews
KW - viral diseases
KW - Dengue virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clinical picture
KW - dengue hemorrhagic fever
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093227169&site=ehost-live&scope=site
UR - http://www.pidj.com/
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Kawasaki disease after vaccination: reports to the Vaccine Adverse Event Reporting System 1990-2007.
AU - Hua, W.
AU - Izurieta, H. S.
AU - Slade, B.
AU - Belay, E. D.
AU - Haber, P.
AU - Tiernan, R.
AU - Woo, E. J.
AU - Iskander, J.
AU - Braun, M. M.
AU - Ball, R.
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
Y1 - 2009///
VL - 28
IS - 11
SP - 943
EP - 947
CY - Hagerstown; USA
PB - Lippincott Williams & Wilkins
SN - 0891-3668
AD - Hua, W.: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 1401 Rockville Pike, Suite 2646S, HFM-222, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20093354801. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Background: Kawasaki disease (KD) is a multisystemic vasculitis primarily affecting children <5 years. A review of RotaTeq (rotavirus vaccine live) clinical trial data revealed higher, though not statistically significantly, KD rates among RotaTeq vaccines than placebo recipients. In June 2007, the RotaTeq label was revised accordingly. Objectives: To describe and assess KD reported to Vaccine Adverse Event Reporting System (VAERS) for all US licensed vaccines. Methods: We reviewed all KD reports received by VAERS from 1990 through mid-October 2007. Cases were characterized by age, gender, onset interval, and vaccine type. Proportional reporting ratio (PRR) was used to evaluate KD reporting for each vaccine compared with all others. Reporting rates were calculated using number of doses distributed as denominator. Results: Through October 14, 2007, 107 KD reports were received by VAERS: 26 were categorized as classic cases, 19 atypical, 52 possible, and 10 were noncases. Of the 97 cases, 91% were children <5 years. There was no clustering of onset intervals after day 1 postvaccination. Before the RotaTeq label revision, the KD PRR was elevated only for Pediarix (DTaP, hepB, and IPV combined) but the KD reporting rate for Pediarix (0.59/100,000 person-years) was much lower than the background incidence rate (9-19/100,000 person-years) for children <5 years in the United States. After the revision, reporting of KD for RotaTeq was stimulated but the reporting rate for RotaTeq (1.47/100,000 person-years) was still much lower than the background rate. Conclusions: Our review does not suggest an elevated KD risk for RotaTeq or other vaccines. Continued postmarketing monitoring for KD is ongoing.
KW - adverse effects
KW - bacterial diseases
KW - children
KW - clinical aspects
KW - human diseases
KW - immunization
KW - Kawasaki disease
KW - reviews
KW - risk
KW - vaccination
KW - vaccines
KW - viral diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - adverse reactions
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - clinical picture
KW - immune sensitization
KW - mucocutaneous lymph node syndrome
KW - United States of America
KW - viral infections
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093354801&site=ehost-live&scope=site
UR - http://www.pidj.com/
UR - email: wei.hua@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbial contamination of select dietary supplements.
AU - Tournas, V. H.
JO - Journal of Food Safety
JF - Journal of Food Safety
Y1 - 2009///
VL - 29
IS - 3
SP - 430
EP - 442
CY - Boston; USA
PB - Blackwell Publishing
SN - 0149-6085
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093235357. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Aromatic & Medicinal Plants; Plant Pathology; Medical & Veterinary Mycology; Human Nutrition
N2 - One hundred thirty-eight dietary supplement samples comprised of alfalfa, Circu-Care, coriander, cumin, echinacea, garlic, ginger, ginkgo, horse chestnut extract, juniper berries, licorice, psyllium, saw palmetto, St. John's wort, valerian, white willow bark, and various vitamins and minerals were obtained from local supermarkets and dietary supplement companies and analyzed for fungal contamination and the presence of aerobic mesophilic bacteria. Results indicated that the highest mold and yeast counts of 5.6×106 colony forming units (cfu) per gram product were found in alfalfa and the lowest (1.0×102 cfu/g) were present in ginger supplements. Potentially toxigenic molds were found in alfalfa, coriander, echinacea, garlic, ginkgo, juniper, licorice, psyllium and St. John's wort supplements. The most common fungi were aspergilli, followed by eurotia, penicillia and yeasts. Alternaria alternata, Fusarium, Cladosporium, Rhizopus and Phoma spp. were isolated less frequently. No molds or yeasts were found in synthetic vitamins, minerals, Circu-Care and valerian. Aerobic mesophilic bacteria were isolated from all commodities tested. The highest aerobic plate count numbers (5.2×106-3.8×107 cfu/g) were recovered from alfalfa, whereas the lowest (<100-5.5×102 cfu/g) were found in vitamins and minerals.
KW - aerobes
KW - food contamination
KW - food supplements
KW - garlic
KW - ginger
KW - liquorice
KW - lucerne
KW - medicinal plants
KW - microbial contamination
KW - mineral supplements
KW - minerals
KW - moulds
KW - toxinogenic fungi
KW - valerian
KW - vitamin supplements
KW - vitamins
KW - yeasts
KW - Aesculus hippocastanum
KW - Allium sativum
KW - Alternaria alternata
KW - Aspergillus
KW - Bacteria
KW - Cladosporium
KW - Coriandrum sativum
KW - Cuminum cyminum
KW - Echinacea
KW - Fusarium
KW - Ginkgo biloba
KW - Glycyrrhiza
KW - Hypericum perforatum
KW - Juniperus
KW - Krascheninnikovia
KW - Medicago
KW - Medicago sativa
KW - Mucoraceae
KW - Penicillium
KW - Phoma
KW - Plantago ovata
KW - Rhizopus
KW - Salix alba
KW - Serenoa repens
KW - Zingiber
KW - Zingiber officinale
KW - fungi
KW - eukaryotes
KW - Aesculus
KW - Hippocastanaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Allium
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - Alternaria
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - prokaryotes
KW - Davidiellaceae
KW - Capnodiales
KW - Coriandrum
KW - Apiaceae
KW - Apiales
KW - Cuminum
KW - Asteraceae
KW - Asterales
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Ginkgo
KW - Ginkgoaceae
KW - Ginkgoopsida
KW - gymnosperms
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - Hypericum
KW - Clusiaceae
KW - Theales
KW - Cupressaceae
KW - Pinopsida
KW - Chenopodiaceae
KW - Caryophyllales
KW - Plantago
KW - Plantaginaceae
KW - Plantaginales
KW - Scrophulariales
KW - Mucoraceae
KW - Mucorales
KW - Mucoromycotina
KW - Zygomycota
KW - Salix
KW - Salicaceae
KW - Salicales
KW - Serenoa
KW - Arecaceae
KW - Arecales
KW - Zingiberaceae
KW - Zingiberales
KW - Zingiber
KW - Medicago
KW - aerobic micro-organisms
KW - aerobic microorganisms
KW - alfalfa
KW - Araliales
KW - bacterium
KW - Coelomycetes
KW - coriander
KW - cumin
KW - drug plants
KW - food contaminants
KW - fungus
KW - ginkgo tree
KW - Hyphomycetes
KW - licorice
KW - maidenhair tree
KW - medicinal herbs
KW - molds
KW - officinal plants
KW - Crop Produce (QQ050)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Non-food/Non-feed Plant Products (SS200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093235357&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/jfs
UR - email: valerie.tournas@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Blood lead, serum homocysteine, and neurobehavioral test performance in the third National Health and Nutrition Examination Survey.
AU - Krieg, E. F., Jr.
AU - Butler, M. A.
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2009///
VL - 30
IS - 2
SP - 281
EP - 289
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0161-813X
AD - Krieg, E. F., Jr.: National Institute for Occupational Safety and Health, Atlanta, Georgia, USA.
N1 - Accession Number: 20093097429. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 68-19-9, 59-30-3, 6027-13-0, 7439-92-1. Subject Subsets: Public Health
N2 - Regression analysis was used to estimate and test for relationships between blood lead, serum folate, red blood cell folate, serum vitamin B12, serum homocysteine, and neurobehavioral test performance in adults, 20-59 years old, participating in the third National Health and Nutrition Examination Survey. The three neurobehavioral tests included in the survey were simple reaction time, symbol-digit substitution, and serial digit learning. Serum folate, red blood cell folate, and serum vitamin B12 decreased as the blood lead concentration increased. Serum homocysteine increased as the blood lead concentration increased. Serum homocysteine decreased as the serum folate and serum vitamin B12 concentrations increased. Neurobehavioral test performance was not related to the blood lead, serum folate, or serum vitamin B12 concentrations. In adults 20-39 years old, performance on the serial digit learning test improved as the serum homocysteine concentration increased. In adults 40-59 years old, neurobehavioral test performance was not related to the serum homocysteine concentration. Homocysteine may impair cognitive function by acting at N-methyl-d-aspartate receptors, and improve cognitive function by acting at N-methyl-d-aspartate or γ-aminobutyric acid receptors.
KW - blood
KW - blood serum
KW - cyanocobalamin
KW - folic acid
KW - homocysteine
KW - lead
KW - mental ability
KW - vitamin B12
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cobalamin
KW - folacin
KW - folate
KW - intelligence
KW - Physiology of Human Nutrition (VV120)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093097429&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W81-4VCNP51-3&_user=6686535&_coverDate=03%2F31%2F2009&_rdoc=16&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236641%232009%23999699997%23985055%23FLA%23display%23Volume)&_cdi=6641&_sort=d&_docanchor=&_ct=22&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=e91ee38d6cc5f1138dbb8686d4105b48
UR - email: erk3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital.
AU - Valencia, R.
AU - Arroyo, L. A.
AU - Conde, M.
AU - Aldana, J. M.
AU - Torres, M. J.
AU - Fernández-Cuenca, F.
AU - Garnacho-Montero, J.
AU - Cisneros, J. M.
AU - Ortíz, C.
AU - Pachón, J.
AU - Aznar, J.
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2009///
VL - 30
IS - 3
SP - 257
EP - 263
CY - Chicago; USA
PB - University of Chicago Press
SN - 0899-823X
AD - Valencia, R.: Preventive Medicine and Public Health Service, Virgen del Rocío Hospital, Avenida Manuel Siurot s/n, Seville 41013, Spain.
N1 - Accession Number: 20093100756. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Public Health
N2 - Objective. To describe what is, to our knowledge, the first nosocomial outbreak of infection with pan-drug-resistant (including colistin-resistant) Acinetobacter baumannii, to determine the risk factors associated with these types of infections, and to determine their clinical impact. Design. Nested case-control cohort study and a clinical-microbiological study. Setting. A 1,521-bed tertiary care university hospital in Seville, Spain. Patients. Case patients were inpatients who had a pan-drug-resistant A. baumannii isolate recovered from a clinical or surveillance sample obtained at least 48 hours after admission to an intensive care unit (ICU) during the time of the epidemic outbreak. Control patients were patients who were admitted to any of the "boxes" (ie, rooms that partition off a distinct area for a patient's bed and the equipment needed to care for the patient) of an ICU for at least 48 hours during the time of the epidemic outbreak. Results. All the clinical isolates had similar antibiotic susceptibility patterns (ie, they were resistant to all the antibiotics tested, including colistin), and, on the basis of repetitive extragenic palindromic-polymerase chain reaction, it was determined that all of them were of the same clone. The previous use of quinolones and glycopeptides and an ICU stay were associated with the acquisition of infection or colonization with pan-drug-resistant A. baumannii. To control this outbreak, we implemented the following multicomponent intervention program: the performance of environmental decontamination of the ICUs involved, an environmental survey, a revision of cleaning protocols, active surveillance for colonization with pan-drug-resistant A. baumannii, educational programs for the staff, and the display of posters that illustrate contact isolation measures and antimicrobial use recommendations. Conclusions. We were not able to identify the common source for these cases of infection, but the adopted measures have proven to be effective at controlling the outbreak.
KW - antibacterial agents
KW - antibiotics
KW - bacterial diseases
KW - cleaning
KW - colonization
KW - decontamination
KW - drug resistance
KW - drug therapy
KW - education programmes
KW - epidemics
KW - glycopeptides
KW - health education
KW - human diseases
KW - infection control
KW - intensive care units
KW - nosocomial infections
KW - outbreaks
KW - quarantine
KW - quinolones
KW - risk factors
KW - surveillance
KW - Spain
KW - Acinetobacter baumannii
KW - man
KW - Acinetobacter
KW - Moraxellaceae
KW - Pseudomonadales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developed Countries
KW - European Union Countries
KW - Mediterranean Region
KW - OECD Countries
KW - Southern Europe
KW - Europe
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - chemotherapy
KW - colistin
KW - educational programs
KW - hospital infections
KW - Education and Training (CC100)
KW - Environmental Pest Management (HH200)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
KW - Other Control Measures (HH700)
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093100756&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/595977
UR - email: raquel.valencia.sspa@juntadeandalucia.es
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prospective comparison of tuberculin skin test and QuantiFERON-TB gold in-tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting.
AU - Cummings, K. J.
AU - Smith, T. S.
AU - Shogren, E. S.
AU - Khakoo, R.
AU - Nanda, S.
AU - Bunner, L.
AU - Smithmyer, A.
AU - Soccorsi, D.
AU - Kashon, M. L.
AU - Mazurek, G. H.
AU - Friedman, L. N.
AU - Weissman, D. N.
JO - Infection Control and Hospital Epidemiology
JF - Infection Control and Hospital Epidemiology
Y1 - 2009///
VL - 30
IS - 11
SP - 1123
EP - 1126
CY - Chicago; USA
PB - University of Chicago Press
SN - 0899-823X
AD - Cummings, K. J.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093295086. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.
KW - assays
KW - diagnostic techniques
KW - health care workers
KW - human diseases
KW - latent infections
KW - skin tests
KW - tuberculin
KW - tuberculosis
KW - man
KW - Mycobacterium tuberculosis
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - intradermal tests
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093295086&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/644754
UR - email: cvx5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague-Dawley rats.
AU - Ferguson, S. A.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Flynn, K. M.
JO - Neurotoxicology and Teratology
JF - Neurotoxicology and Teratology
Y1 - 2009///
VL - 31
IS - 3
SP - 143
EP - 148
CY - New York; USA
PB - Elsevier
SN - 0892-0362
AD - Ferguson, S. A.: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093141037. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 446-72-0, 7440-23-5. Subject Subsets: Human Nutrition
N2 - Previous work in our laboratory indicated that lifelong dietary exposure to estrogen-like endocrine disrupters increased sodium solution intake in adult male and female rats. Here, we sought to discern the critical periods necessary for this alteration as well as establish the effects of lower dietary concentrations of genistein and nonylphenol. Male and female Sprague-Dawley rats (F0) consumed phytoestrogen-free chow containing 0, 5, 100, or 500 ppm genistein (~0.0, 0.4, 8.0, and 40.0 mg/kg/day) or 0, 25, 200, or 750 ppm nonylphenol (~0.0, 2.0, 16.0, and 60.0 mg/kg/day). Rats were mated within treatment groups and offspring (F1) maintained on the same diets. Mating for the F1, F2, and F3 (genistein only) was within treatment groups. At postnatal day (PND) 21, the F3 generation began to consume unadulterated phytoestrogen-free chow such that genistein exposure occurred only in utero and preweaning. The F4 generation was never directly exposed to genistein. On PNDs 65-68, intake of regular water and a 3.0% sodium chloride solution was measured for F1-F4 generations (genistein portion) or F1-F2 (nonylphenol portion). Although body weights were decreased by the highest dietary concentrations of genistein and nonylphenol, there were only minimal effects of exposure on sodium solution intake. As expected, intake was highest in female rats. With previous data, these results indicate that the dietary concentrations necessary to increase adult sodium solution intake in rats are greater than 500 ppm genistein and 750 ppm nonylphenol and such effects do not appear to increase across generations.
KW - animal models
KW - diet
KW - exposure
KW - genistein
KW - intake
KW - isoflavones
KW - laboratory animals
KW - phenols
KW - plant oestrogens
KW - sodium
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - biochanin A
KW - phytoestrogens
KW - plant estrogens
KW - Animal Models of Human Nutrition (VV140)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093141037&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9X-4VDY7YV-3&_user=6686535&_coverDate=06%2F30%2F2009&_rdoc=2&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235126%232009%23999689996%231066151%23FLA%23display%23Volume)&_cdi=5126&_sort=d&_docanchor=&_ct=9&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=59ad1fc216fd35569c45ee7872927173
UR - email: Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Searching for HAdV-52, the putative gastroenteritis-associated human adenovirus serotype in Southern Hungary.
AU - Bányai, K.
AU - Martella, V.
AU - Meleg, E.
AU - Kisfali, P.
AU - Péterfi, Z.
AU - Benkö, M.
AU - Melegh, B.
AU - Szucs, G.
JO - New Microbiologica
JF - New Microbiologica
Y1 - 2009///
VL - 32
IS - 2
SP - 185
EP - 188
CY - Pavia; Italy
PB - Edizioni Internazionali Srl
SN - 1121-7138
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20103139978. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - Human adenovirus (HAdV) serotype 52 has recently been discovered in the United States in samples from human patients with gastroenteritis of unknown etiology and is suspected to be a new human enteric pathogen. The aim of the present pilot study was to investigate whether this virus is circulating in the population of Southern Hungary by screening stool specimens collected from gastroenteritis cases and communal sewage samples in the area of Baranya County. A total of 209 diarrheic stool (124 from children and 85 from adults) and 45 influent sewage samples were screened for HAdV-52 by PCR using a primer pair specific to the gene of 12.5K protein in the E3 genomic region. The novel human adenovirus was not detected in any of the tested samples, suggesting that HAdV-52 was not circulating in the target population and the area during the study period. Since temporal and geographical fluctuations may markedly affect the epidemiology of human enteric pathogens, additional investigations are required to gain more indepth insights into the ecology of this novel adenovirus.
KW - diarrhoea
KW - faeces
KW - gastroenteritis
KW - gastrointestinal diseases
KW - human diseases
KW - polymerase chain reaction
KW - screening
KW - sewage
KW - viral diseases
KW - Hungary
KW - Human adenovirus
KW - man
KW - Mastadenovirus
KW - Adenoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - diarrhea
KW - feces
KW - Human adenovirus 52
KW - PCR
KW - scouring
KW - screening tests
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103139978&site=ehost-live&scope=site
UR - http://www.microbiologica.net/mb/pdf/2009/2/Micro2_11_Banyai.pdf
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Toxicological evaluation of an apicidin derivative, histone deacetylase inhibitor SD-2007 in mice.
AU - Kwack SeungJun
AU - Kim KyuBong
AU - Lee ByungMu
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
Y1 - 2009///
VL - 32
IS - 5
SP - 789
EP - 797
CY - Seoul; Korea Republic
PB - Pharmaceutical Society of Korea
SN - 0253-6269
AD - Kwack SeungJun: Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20093183112. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9000-86-6, 9001-78-9, 9000-97-9, 9001-60-9.
N2 - SD-2007 is a new derivative of apicidin, an anti-parasitic agent and a histone deacetylase (HDAC) inhibitor. A subacute toxicological evaluation of SD-2007 was investigated for 2 weeks in ICR mice. After oral administration of SD-2007 (0, 0.2, 1, 5 or 25 mg/mouse), the clinical signs, mortalities, body weight changes, blood biochemical parameters, absolute and relative organ weights were examined. One day after the administration of SD-2007, excretion of soft feces in 1 and 5 mg/head groups, and one male in 25 mg/mouse group developed diarrhea, but theses complications were disappeared two days after administration. No mortalities were observed in animals up to 25 mg/mouse (LD50, >25 mg/kg), but absolute and relative weights of testes were significantly lower at the highest dose group (25 mg/mouse) and serum LDH and glucose levels were elevated in male mice. In addition, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities were reduced in female mice at all dosages. These data suggest that SD- 2007 may be sex specific and be toxic to the male reproductive organ, and thus our findings require further investigation and in particular chronic toxicological investigations should be investigated.
KW - adverse effects
KW - alanine aminotransferase
KW - alkaline phosphatase
KW - animal models
KW - antiparasitic agents
KW - aspartate aminotransferase
KW - blood serum
KW - blood sugar
KW - diarrhoea
KW - enzyme activity
KW - enzyme inhibitors
KW - hydrolases
KW - laboratory animals
KW - lactate dehydrogenase
KW - testes
KW - toxicity
KW - toxicology
KW - weight
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - alkaline phosphomonoesterase
KW - apicidin
KW - blood glucose
KW - diarrhea
KW - glucose in blood
KW - glutamate pyruvate transaminase
KW - glutamic pyruvic transaminase
KW - GOT
KW - GPT
KW - histone deacetylase
KW - parasiticides
KW - scouring
KW - SD-2007
KW - testicles
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093183112&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/a2461576j35rw5nm/fulltext.pdf
UR - email: bmlee@skku.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The analgesic effect of decursinol.
AU - Seo YoungJun
AU - Kwon MinSoo
AU - Park SooHyun
AU - Sim YunBeom
AU - Choi SeungMin
AU - Huh GyungHe
AU - Lee JinKoo
AU - Suh HongWon
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
Y1 - 2009///
VL - 32
IS - 6
SP - 937
EP - 943
CY - Seoul; Korea Republic
PB - Pharmaceutical Society of Korea
SN - 0253-6269
AD - Seo YoungJun: Division of Recombinant Products, Biopharmaceutical Bureau, Korea Food and Drug Administration, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20093204255. Publication Type: Journal Article. Language: English. Registry Number: 11000-26-3. Subject Subsets: Aromatic & Medicinal Plants
N2 - Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet. In this study, we characterized the possible interaction between decursinol and aspirin or acetaminophen in the writhing test. The antinociceptive effects of decursinol were observed at an orally-administered dose of 50 mg/kg but not at 25 or 10 mg/kg. In addition, the analgesic effects of aspirin (ASA) and acetaminophen (APAP) were shown at an orally-administered dose of 200 mg/kg but not at 50 or 100 mg/kg. We examined the effects of decursinol on the ASA or APAP at sub-analgesic doses. Although the co-administration of decursinol and ASA did not show any differences at doses of 10 or 25 mg/kg and 50 or 100 mg/kg, respectively, synergistic effects between decursinol and APAP were observed in the group of decursinol (25 mg/kg) and APAP (100 mg/kg) co-administration. These results indicated that the analgesic effect of decursinol might be involved in supraspinal cyclooxygenase regulation that might be overlapped with APAP-induced analgesic mechanisms rather than systemic or peripheral prostaglandin modulation.
KW - analgesic properties
KW - coumarins
KW - dosage effects
KW - medicinal plants
KW - plant extracts
KW - prostaglandins
KW - roots
KW - Angelica gigas
KW - mice
KW - Angelica
KW - Apiaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - antinociceptive properties
KW - Araliales
KW - drug plants
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093204255&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/bu24r81461n661t8/?p=5687fb54e4ba48769b619e1ffc926871&pi=18
UR - email: hwsuh@hallym.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of membrane assisted solvent extraction, stir bar sorptive extraction, and solid phase microextraction in analysis of tetramine in food.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Journal of Separation Science
JF - Journal of Separation Science
Y1 - 2009///
VL - 32
IS - 7
SP - 1081
EP - 1086
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1615-9306
AD - Jager, L. S. de: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20093132817. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Human Nutrition
N2 - Three environmentally friendly extraction techniques, membrane assisted solvent extraction (MASE), stir bar sorptive extraction (SBSE), and headspace solid phase microextraction (HS-SPME), were compared for the direct analysis of the highly toxic rodenticide tetramine in food. The optimized MASE method was applied to seven foods fortified with tetramine and compared to previously reported SBSE and HS-SPME results. Parameters such as the standard addition linearity (MASE (0.964-0.999), SBSE (0.966-0.999), HS-SPME (0.955-0.999)), recovery (MASE (12-86%), SBSE (36-130%), HS-SPME (50-200%)), reproducibility (MASE (3.0-30%), SBSE (4.4-9.6%), HS-SPME (1-12%)), and LOD (MASE (1.6-6.4 ng/g), SBSE (0.2-2.1 ng/g), HS-SPME (0.9-4.3 ng/g)) were compared.
KW - analytical methods
KW - extraction
KW - food analysis
KW - rodenticides
KW - solvents
KW - analytical techniques
KW - headspace solid phase microextraction
KW - membrane assisted solvent extraction
KW - solid phase microextraction
KW - stir bar sorptive extraction
KW - tetramine
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093132817&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/cgi-bin/jtoc/76510662/
UR - email: lowri.dejager@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - College students' motivation to achieve and maintain a healthy weight.
AU - Furia, A. C.
AU - Lee, R. E.
AU - Strother, M. L.
AU - Huang, T. T. K.
JO - American Journal of Health Behavior
JF - American Journal of Health Behavior
Y1 - 2009///
VL - 33
IS - 3
SP - 256
EP - 263
CY - Star City; USA
PB - PNG Publications
SN - 1087-3244
AD - Furia, A. C.: Office of Special Health Issues, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093180024. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Objectives: To develop and refine a scale of motivational factors related to healthy weight achievement and maintenance and to examine differences by gender and weight status. Methods: A cross-sectional survey of 300 university students aged 18-24 years. Results: Factor analysis yielded 6 factors - Intrinsic (Cronbach's α=0.73): affective motivation, self-efficacy/interest; Extrinsic (Cronbach's α=0.68): social reward, peer pressure, lack of choice, and authority influence. Males and normal-weight students showed higher affective motivation and overall intrinsic motivation compared to females and overweight students, (P<.001). Conclusion: Intrinsic motivational factors and gender differences should be considered in developing obesity prevention interventions in this age-group.
KW - body weight
KW - college students
KW - motivation
KW - obesity
KW - overweight
KW - peer influence
KW - sex differences
KW - weight control
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - fatness
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Nutrition (General) (VV100)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093180024&site=ehost-live&scope=site
UR - http://www.ajhb.org/
UR - email: huangter@mail.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Disparities in obesity and overweight prevalence among US immigrant children and adolescents by generational status.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Yu, S. M.
JO - Journal of Community Health
JF - Journal of Community Health
Y1 - 2009///
VL - 34
IS - 4
SP - 271
EP - 281
CY - Dordrecht; Netherlands
PB - Springer
SN - 0094-5145
AD - Singh, G. K.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20093220530. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Subject Subsets: Public Health
N2 - We examined the prevalence and socio-behavioral correlates of obesity and overweight among 46,707 immigrant and US-born children and adolescents aged 10-17 years. The 2003 National Survey of Children's Health was used to estimate obesity and overweight prevalence among children in 12 immigrant groups, stratified by race/ethnicity and generational status. Logistic regression was used to examine immigrant differentials in the prevalence and odds of obesity and overweight. Obesity and overweight prevalence varied from a low of 6 and 18% for second-generation Asian immigrants to a high of 24 and 42% for native-born black children (US-born black children with US-born parents), respectively. After adjusting for age, gender, ethnicity, socioeconomic status, perceived neighborhood safety, television viewing, computer use, and physical activity, first-generation immigrant children, overall, had 26% lower odds of obesity than native-born children. Obesity and overweight prevalence was lower for immigrant black and white children than their native-born counterparts, while obesity and overweight prevalence among Hispanic children did not vary significantly by generational status. Compared with native-born white children, the adjusted odds of obesity were 64% higher for native-born blacks, 55% higher for second-generation Hispanic immigrants, and 63% lower for first-generation Asian immigrants. Adjusted immigrant differentials in overweight risks were also marked. Socioeconomic, demographic, and behavioral factors accounted for 61 and 35% of ethnic-immigrant disparities in obesity and overweight prevalence, respectively. Immigrant patterns in childhood obesity and overweight vary substantially by ethnicity and generational status. To reduce disparities, obesity prevention programs must target at-risk children of both immigrant and US-born parents.
KW - adolescents
KW - African Americans
KW - Asians
KW - behaviour
KW - blacks
KW - children
KW - disparity
KW - epidemiology
KW - ethnic groups
KW - ethnicity
KW - Hispanics
KW - human behaviour
KW - immigrants
KW - obesity
KW - overweight
KW - socioeconomic status
KW - whites
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior
KW - ethnic differences
KW - fatness
KW - human behavior
KW - teenagers
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093220530&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=101596
UR - email: gsingh@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethnic health care advisors: a good strategy to improve the access to health care and social welfare services for ethnic minorities?
AU - Hesselink, A. E.
AU - Verhoeff, A. P.
AU - Stronks, K.
JO - Journal of Community Health
JF - Journal of Community Health
Y1 - 2009///
VL - 34
IS - 5
SP - 419
EP - 429
CY - Dordrecht; Netherlands
PB - Springer
SN - 0094-5145
AD - Hesselink, A. E.: Department of Epidemiology and Health Promotion, Public Health Service Amsterdam, P.O. Box 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20093330113. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Rural Development; Tropical Diseases
N2 - Empirical studies indicate that ethnic minorities have limited access to health care and welfare services compared with the host population. To improve this access, ethnic health care (HC) advisors were introduced in four districts in Amsterdam, the Netherlands. HC advisors work for all health care and welfare services and their main task is to provide information on health care and welfare to individuals and groups and refer individuals to services. Action research was carried out over a period of 2 years to find out whether and how this function can contribute to improve access to services for ethnic minorities. Information was gathered by semi-structured interviews, analysing registration forms and reports, and attending meetings. The function's implementation and characteristics differed per district. The ethnicity of the health care advisors corresponded to the main ethnic groups in the district: Moroccan and Turkish (three districts) and sub-Sahara African and Surinamese (one district). HC advisors reached many ethnic inhabitants (n=2,224) through individual contacts. Half of them were referred to health care and welfare services. In total, 576 group classes were given. These were mostly attended by Moroccan and Turkish females. Outreach activities and office hours at popular locations appeared to be important characteristics for actually reaching ethnic minorities. Furthermore, direct contact with a well-organized back office seems to be important. HC advisors were able to reach many ethnic minorities, provide information about the health care and welfare system, and refer them to services. Besides adapting the function to the local situation, some general aspects for success can be indicated: the ethnic background of the HC advisor should correspond to the main ethnic minority groups in the district, HC advisors need to conduct outreach work, there must be a well-organized back office to refer clients to, and there needs to be enough commitment among professionals of local health and welfare services.
KW - access
KW - advisory committees
KW - ethnic groups
KW - ethnicity
KW - health care
KW - human diseases
KW - welfare services
KW - Africa South of Sahara
KW - Morocco
KW - Netherlands
KW - Suriname
KW - Turkey
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Africa
KW - Developing Countries
KW - Francophone Africa
KW - Maghreb
KW - North Africa
KW - Mediterranean Region
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - ACP Countries
KW - Caribbean Community
KW - South America
KW - America
KW - West Asia
KW - Asia
KW - ethnic differences
KW - subsaharan Africa
KW - Surinam
KW - Public Services and Infrastructure (UU300)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093330113&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/link.asp?id=101596
UR - email: ahesselink@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Discussion on role of enterprises in re-evaluation of traditional Chinese medicine injection.
AU - Li XinLing
AU - Song LiGang
AU - Liu Ying
AU - Bo YanJun
JO - China Journal of Chinese Materia Medica
JF - China Journal of Chinese Materia Medica
Y1 - 2009///
VL - 34
IS - 10
SP - 1326
EP - 1328
CY - Beijing; China
PB - Editorial Board of China Journal of Chinese Materia Medica
SN - 1001-5302
AD - Li XinLing: Center for Drug Reevaluation, State Food and Drug Administration, Beijing, 100045, China.
N1 - Accession Number: 20103054482. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 7 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - By analyzing several aspects of the problem of traditional Chinese medicine injection on basic research, quality standards, production technology and clinical application, put forward content and steps of re-evaluation of traditional Chinese medicine injection.
KW - clinical trials
KW - enterprises
KW - herbal drugs
KW - injection
KW - medicinal plants
KW - pharmacology
KW - quality standards
KW - traditional Chinese medicines
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103054482&site=ehost-live&scope=site
UR - http://www.cjcmm.com.cn
UR - email: lixinling@cdr.gov.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Retrospective study of adverse events of Polygonum multiflorum and risk control.
AU - Zhang Li
AU - Yang XiaoHui
AU - Sun ZhenXiao
AU - Qu Yi
JO - China Journal of Chinese Materia Medica
JF - China Journal of Chinese Materia Medica
Y1 - 2009///
VL - 34
IS - 13
SP - 1724
EP - 1729
CY - Beijing; China
PB - Editorial Board of China Journal of Chinese Materia Medica
SN - 1001-5302
AD - Zhang Li: Center for Drug Reevaluation, State Food and Drug Administration, Beijing 100045, China.
N1 - Accession Number: 20103054405. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 10 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - To provide a reference for rational clinical medication and review the irrational use and factors relating the adverse events of Polygonum multiflorum. The literatures on P. multiflorum published between 1978 and 2008 were reviewed and the reports on clinical use were analyzed. A total of 26 literatures were retrieved. 38 cases of adverse drug event were reported, 10 cases of allergy, 24 cases of liver damage, and 4 cases presented with other adverse events. Irrational use is common in both self-medication and doctor prescription. It is one of the main factors of adverse events. Improving clinical rational use is the most important way to control its risk.
KW - adverse effects
KW - pharmacology
KW - reviews
KW - risk assessment
KW - safety
KW - man
KW - Polygonum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Polygonaceae
KW - Polygonales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Polygonum
KW - adverse reactions
KW - Polygonum multiflorum
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103054405&site=ehost-live&scope=site
UR - http://www.cjcmm.com.cn
UR - email: yty0616@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation and consideration on safety information abroad of Polygonum multiflorum and its preparations.
AU - Zhang Li
AU - Yang XiaoHui
AU - Deng YuanYuan
JO - China Journal of Chinese Materia Medica
JF - China Journal of Chinese Materia Medica
Y1 - 2009///
VL - 34
IS - 18
SP - 2414
EP - 2418
CY - Beijing; China
PB - Editorial Board of China Journal of Chinese Materia Medica
SN - 1001-5302
AD - Zhang Li: National Center for Drug Reevaluation, State Food and Drug Administration, Beijing 100045, China.
N1 - Accession Number: 20103054340. Publication Type: Journal Article. Language: Chinese. Language of Summary: English. Number of References: 15 ref. Subject Subsets: Postharvest Research; Aromatic & Medicinal Plants
N2 - This article retrospectively analyzed the safety reports published abroad regarding Polygonum multiflorum and its preparations in terms of drug use and liver damage. The authors found that the foreign drug regulatory authorities are lack of in-depth analysis and investigation on the safety information of P. multiflorum and its preparations in the process of reporting and warning. Therefore, the authors consider the following factors are significant for scientific evaluation of traditional Chinese medicine (TCM) safety; follow-up and investigation of the information based on literature study, establishment of the safety-related information communication and feedback mechanism with foreign drug regulatory authorities and drafting of the guidelines for rational use of TCM.
KW - adverse effects
KW - herbal drugs
KW - liver failure
KW - medicinal plants
KW - pharmacology
KW - safety
KW - traditional Chinese medicines
KW - Polygonum
KW - Polygonaceae
KW - Polygonales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - adverse reactions
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Polygonum multiflorum
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Non-food/Non-feed Plant Products (SS200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103054340&site=ehost-live&scope=site
UR - http://www.cjcmm.com.cn
UR - email: yty0616@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the filtration performance of 21 N95 filtering face piece respirators after prolonged storage.
AU - Viscusi, D. J.
AU - Bergman, M.
AU - Sinkule, E.
AU - Shaffer, R. E.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2009///
VL - 37
IS - 5
SP - 381
EP - 386
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Viscusi, D. J.: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania, USA.
N1 - Accession Number: 20093164337. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: Organizations are stockpiling respirators to prepare for an influenza pandemic. To understand better the effects of prolonged storage, this investigation evaluated the filtration efficiency of 21 different models of National Institute for Occupational Safety and Health (NIOSH)-certified disposable N95 filtering face piece respirators. These respirators had been stored in their original packaging for a period of at least 6 years in research laboratories and dry warehouse facilities, ranging in temperature between 15°C and 32°C and relative humidity between 20% and 80%. Methods: Filter penetration was measured using an abbreviated version of the NIOSH respirator certification test incorporating a polydisperse sodium chloride aerosol at 85 L/min. Results: Of the 21 respirator models tested, 19 models had both average penetration results of less than 5%. Mean initial penetration values ranged from 0.39% to 5.83%, whereas mean maximum penetration values ranged from 0.95% to 5.83%. There did not appear to be any correlation between the length of storage and failure to pass the filtration test. Conclusion: Results indicate that most N95 filtering face piece respirators stored for up to 10 years at warehouse conditions will likely have expected levels of filtration performance and that the degree of filtration efficiency degradation is likely model specific.
KW - disease prevention
KW - filtration
KW - influenza
KW - influenza viruses
KW - relative humidity
KW - storage
KW - temperature
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - flu
KW - Influenzavirus
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093164337&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4VH8XXX-1&_user=10&_coverDate=06%2F30%2F2009&_rdoc=8&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236686%232009%23999629994%231130226%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=273&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=59d42c87074cc6eb4d0667e5ce645aea
UR - email: RShaffer@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Computational toxicology approaches at the US Food and Drug Administration.
AU - Yang, C. H.
AU - Valerio, L. G., Jr.
AU - Arvidson, K. B.
JO - ATLA, Alternatives to Laboratory Animals
JF - ATLA, Alternatives to Laboratory Animals
Y1 - 2009///
VL - 37
IS - 5
SP - 523
EP - 531
CY - Nottingham; UK
PB - Fund for the Replacement of Animals in Medical Experiments
SN - 0261-1929
AD - Yang, C. H.: Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20103042041. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Animal Nutrition; Veterinary Science; Veterinary Science
N2 - For over a decade, the United States Food and Drug Administration (US FDA) has been engaged in the applied research, development, and evaluation of computational toxicology methods used to support the safety evaluation of a diverse set of regulated products. The basis for evaluating computational toxicology methods is multi-factorial, including the potential for increased efficiency, reduction in the numbers of animals used, lower costs, and the need to explore emerging technologies that support the goals of the US FDA's Critical Path Initiative (e.g. to make decision support information available early in the drug review process). The US FDA's efforts have been facilitated by agency-approved data-sharing agreements between government and commercial software developers. This commentary review describes former and current scientific initiatives at the agency, in the area of computational toxicology methods. In particular, toxicology-based QSAR models, ToxML databases and knowledgebases will be addressed. Notably, many of the computational toxicology tools available are commercial products - however, several are emerging as non-commercial products, which are freely-available to the public, and which will facilitate the understanding of how these programs work and avoid the "black box" paradigm. Through productive collaborations, the US FDA Center for Drug Evaluation and Research, and the Center for Food Safety and Applied Nutrition, have worked together to evaluate, develop and apply these methods to chemical toxicity endpoints of regulatory interest.
KW - animal nutrition
KW - animal testing alternatives
KW - computer software
KW - costs
KW - databases
KW - evaluation
KW - food safety
KW - methodology
KW - models
KW - nutrition
KW - objectives
KW - risk assessment
KW - safety
KW - techniques
KW - toxicity
KW - toxicology
KW - USA
KW - animals
KW - man
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alternatives to animal testing
KW - computer programs
KW - costings
KW - data banks
KW - goals
KW - methods
KW - targets
KW - United States of America
KW - Animal Nutrition (General) (LL500)
KW - Information and Documentation (CC300)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
KW - Animal Nutrition (Production Responses) (LL520)
KW - Toxicology and Poisoning of Animals (LL950) (New March 2000)
KW - Laboratory Animal Science (LL040)
KW - Food Service (QQ700) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103042041&site=ehost-live&scope=site
UR - http://www.frame.org.uk
UR - email: chihae.yang@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of institutional practices for prevention of phlebotomy-associated percutaneous injuries in hospital settings.
AU - Knapp, M. B.
AU - Grytdal, S. P.
AU - Chiarello, L. A.
AU - Sinkowitz-Cochran, R. L.
AU - Zombeck, A.
AU - Klein, C.
AU - Warden, B.
AU - Lyden, J.
AU - Pearson, M. L.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2009///
VL - 37
IS - 6
SP - 490
EP - 494
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Knapp, M. B.: Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20093231300. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background: To reduce the incidence of phlebotomy-related percutaneous injuries (PIs), factors that contribute to these injuries must be identified. This study examined institutional phlebotomy practices, policies, perceptions, and culture to identify facilitators and barriers that appear to have the greatest impact in preventing injuries. Methods: During site visits at study hospitals, observational data were collected during the performance of phlebotomy. In addition, interviews and focus groups were conducted with hospital personnel involved in phlebotomy procedures. Results: Nine hospitals participated in the study. A total of 126 phlebotomy procedures were observed. Health care personnel chose devices with safety features for the majority of observed procedures (n=122, 97%). Recommended phlebotomy practices for handling needles after use were observed in 42% to 92% of procedures. Adherence varied by type of device, occupation, and facility PI rate. In the 23 interviews and 9 focus groups, participants identified factors that facilitated PI prevention such as the availability and use of devices with safety mechanisms, adherence to recommended safe needle-handling practices, and institutional phlebotomy training. Conclusion: The quantitative and qualitative data indicate that a wide array of factors can affect phlebotomy-related practices and perceptions. Prevention of PIs may require comprehensive, multifaceted intervention efforts to improve the safety culture and reduce PIs and exposure to bloodborne pathogens in health care facilities.
KW - disease incidence
KW - disease prevention
KW - epidemiology
KW - health care
KW - hospitals
KW - phlebotomy
KW - safety
KW - trauma
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - traumas
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093231300&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4VH8XXX-2&_user=10&_coverDate=08%2F31%2F2009&_rdoc=15&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236686%232009%23999629993%231362049%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=27&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=0bda9d0dd4d0d62e4bc95590684835e2
UR - email: rls7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preventing evictions as a potential public health intervention: characteristics and social medical risk factors of households at risk in Amsterdam.
AU - Laere, I. van
AU - Wit, M. de
AU - Klazinga, N.
JO - Scandinavian Journal of Public Health
JF - Scandinavian Journal of Public Health
Y1 - 2009///
VL - 37
IS - 7
SP - 697
EP - 705
CY - London; UK
PB - Sage Publications Ltd
SN - 1403-4948
AD - Laere, I. van: GGD Municipal Public Health Service Amsterdam, Dr Valckenier Outreach Primary Care Practice for the Homeless, PO BOX 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20093259727. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - Aims: The public health problems precipitating evictions are understudied and no systemic data have been collected. We aim to identify the magnitude of evictions and the characteristics and social medical risk factors of households at risk in Amsterdam. This will help inform policies designed to prevent eviction. Methods: In 2003, case workers of housing associations dealing with rent arrears, and case workers of nuisance control care networks, were interviewed and completed questionnaires about households at risk of eviction. Questionnaires included the processes that resulted in eviction and the characteristics and social medical problems of the households involved. Evicted households were compared with non-evicted households. Results: In Amsterdam, over recent years 1,400 evictions, or four per 1,000 dwellings, took place annually. Of 275 households with rent arrears, 132 were evicted. Of 190 nuisance households, 136 were evicted. In both groups, the largest household group were single male tenants between 25 and 44 years. For those reporting rent arrears, social problems were reported in 71%, medical problems in 23%; independent risk factors for eviction were being of Dutch origin (OR 2.38 (1.30-4.36)) and having a drug-addiction problem (OR 3.58 (0.96-13.39)). For the nuisance households, social problems were reported in 46% and medical problems in 82%, while financial difficulties were a risk factor for eviction (OR: 8.04 (1.05-61.7)). Conclusions: In Amsterdam, households at risk of eviction consisted mainly of single (Dutch) men, aged between 25 and 44 years, often with a combination of social and medical problems. Financial difficulties and drug addiction were independent risk factors for eviction. Because of the social medical problems that were prevalent, for prevention practice evictions should be considered both a socioeconomic and a public health problem. Preventing evictions deserves full attention as a potential effective public health intervention.
KW - drug addiction
KW - households
KW - public health
KW - questionnaires
KW - risk factors
KW - socioeconomic status
KW - sociology
KW - Netherlands
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - social aspects
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093259727&site=ehost-live&scope=site
UR - http://sjp.sagepub.com/archive/
UR - email: ivlaere@ggd.amsterdam.nl\laere@telfort.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009.
AU - Edwards, J. R.
AU - Peterson, K. D.
AU - Mu, Y.
AU - Banerjee, S.
AU - Allen-Bridson, K.
AU - Morrell, G.
AU - Dudeck, M. A.
AU - Pollock, D. A.
AU - Horan, T. C.
JO - AJIC - American Journal of Infection Control
JF - AJIC - American Journal of Infection Control
Y1 - 2009///
VL - 37
IS - 10
SP - 783
EP - 805
CY - St. Louis; USA
PB - Elsevier Inc.
SN - 0196-6553
AD - Edwards, J. R.: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Mailstop A-24, Atlanta, GA 30333, USA.
N1 - Accession Number: 20103002520. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This report is a summary of device-associated (DA) and procedure-associated (PA) module data collected and reported by hospitals and ambulatory surgical centers participating in the National Healthcare Safety Network (NHSN) from January 2006 through December 2008. Tables included reflect device-associated infection rates, device utilization (DU) ratios, select attributes of device-associated infections, procedure-associated infection rates, SSI rates by operative procedure type, NNIS risk index categories, and PPP rates by procedure. 1545 hospitals, located in 48 states and the District of Columbia, and 20 outpatient surgery centers had reported at least denominator data for some patient cohorts under surveillance. Comparing data to the last NHSN Report reveal several differences. All CLABSI rates exclude BSIs reported using criterion 2b or 3b. Change of composition of reporting hospitals is apparent in the nearly 3-fold increase in the number of medical/surgical ICUs. Also, there has been increased reporting of device-associated infections from inpatient wards, which is apparent in the 5-fold increase in the number of medical wards reporting CLABSI rates. In this report, several of the device-associated rates in NICUs were lower. Furthermore, though the number of device days and patient days nearly doubled in each birth-weight group, the device utilization ratios stayed essentially the same. Specific site of ventilator-associated pneumonia most frequently reported, regardless of location, was the clinical criterion (PNU1). The specific site of catheter-associated UTI was equally reported between symptomatic UTI and asymptomatic bacteriuria. Report of pooled mean PPP rates remain very low, ranging from 0% for vaginal hysterectomy to 1.41% for abdominal aortic aneurysm repair procedures. SSI rates were very similar or slightly lower compared to the previous. The characteristics of hospitals reporting to NHSN continue to evolve, including a sustained influx of smaller hospitals.
KW - bacterial diseases
KW - catheters
KW - epidemiology
KW - equipment
KW - health centres
KW - hospitals
KW - human diseases
KW - monitoring
KW - nosocomial infections
KW - patients
KW - pneumonia
KW - safety
KW - surgical operations
KW - surveillance
KW - urinary tract infections
KW - ventilators
KW - USA
KW - bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - health centers
KW - hospital infections
KW - surveillance systems
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103002520&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9M-4XWWJ6K-5&_user=10&_coverDate=12%2F31%2F2009&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236686%232009%23999629989%231577298%23FLA%23display%23Volume)&_cdi=6686&_sort=d&_docanchor=&_ct=21&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=884195933b01bef3228013ff539d299c
UR - email: JREdwards@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Venomous spiders, snakes, and scorpions in the United States.
AU - Holve, S.
A2 - Derlet, M. N.
T3 - Special Issue: The great outdoors: medical care in rural and remote environments.
JO - Pediatric Annals
JF - Pediatric Annals
Y1 - 2009///
VL - 38
IS - 4
SP - 210
EP - 217
CY - Thorofare; USA
PB - Slack Incorporated
SN - 0090-4481
AD - Holve, S.: Indian Health Service, Tuba City Regional Health Care Corporation, PO Box 600, 167 North Main Street, Tuba City, AZ 86045, USA.
N1 - Accession Number: 20093118967. Publication Type: Journal Article. Note: Special Issue: The great outdoors: medical care in rural and remote environments. Language: English. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Public Health
KW - antivenoms
KW - children
KW - disease incidence
KW - envenomation
KW - epidemiology
KW - human diseases
KW - rural areas
KW - snake bites
KW - stings
KW - venoms
KW - USA
KW - Araneae
KW - man
KW - Scorpiones
KW - snakes
KW - Arachnida
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - reptiles
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antivenins
KW - spiders
KW - United States of America
KW - venom
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Rural Health (VV550) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093118967&site=ehost-live&scope=site
UR - http://www.pediatricsupersite.com/view.aspx?rid=38464
UR - email: steve.holve@tchealth.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An investigation on characteristics of the vibration transmitted to wrist and elbow in the operation of impact wrenches.
AU - Xu, X. S.
AU - Welcome, D. E.
AU - McDowell, T. W.
AU - Warren, C.
AU - Dong, R. G.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2009///
VL - 39
IS - 1
SP - 174
EP - 184
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Xu, X. S.: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093022477. Publication Type: Journal Article. Language: English. Number of References: 33 ref. Subject Subsets: Public Health
N2 - To help assess the risk of the vibration exposure during impact wrench operation and to develop a convenient and effective method to monitor and control the exposure, this study aims to investigate the characteristics of the vibrations transmitted to the wrist and elbow in the operation and to evaluate the on-the-wrist and on-the-elbow vibration measurement methods. Six subjects participated in the experiment. Each of them used 15 impact wrenches on a simulated workstation. Tri-axial accelerations at three locations (tool handle, wrist, and elbow) and the tool effective torques were measured and used in the evaluations. Results confirm that the severity of the vibration exposure generally depends on tool and individual, and that the vibrations measured at wrist and elbow reflect the influences of both factors. This study also found that the accelerations measured at the wrist and elbow are correlated with the ISO frequency-weighted tool acceleration. The fundamental resonance of the hand-arm system in the range of 16-50 Hz is well reflected in the vibration measured at the wrist. The results also demonstrate that vibration exposure duration can be reliably detected from the wrist vibration data. Moreover, the wrist vibration is suggestively correlated with the torque of the pneumatic impact wrenches. These findings suggest that the measurement of the wrist vibration can be used as an alternative approach to perform the exposure risk assessment and to monitor and control the exposures in the operation of the impact wrenches. Relevance to Industry: Impact wrenches or nut runners with impact action are widely and intensively used in automobile manufacturing and repair, which could generate significant vibration and require forceful actions. Prolonged, intensive exposure to both vibration and forceful actions could result in hand-arm vibration syndrome and carpal tunnel syndrome. The results of this study suggest that the on-the-wrist vibration measurement is a reasonable alternative approach for quantifying and assessing the exposures, which provides a theoretical base for developing a convenient and effective method for monitoring and controlling the combined exposures. The results of this study also suggest that the on-the-wrist method can also be used at workplaces to perform screening tests of the tools with dominant vibration frequencies similar to those of the impact wrenches and to evaluate the effectiveness of the anti-vibration devices used with such tools.
KW - joints (animal)
KW - limbs
KW - occupational hazards
KW - occupational health
KW - spanners
KW - vibration
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - wrenches
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093022477&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V31-4T4HJ97-1&_user=6686535&_coverDate=01%2F31%2F2009&_rdoc=24&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235717%232009%23999609998%23799348%23FLA%23display%23Volume)&_cdi=5717&_sort=d&_docanchor=&_ct=37&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=4a31437b5d28cb1a2d779c997538a8f7
UR - email: xxu1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - External L5-S1 joint moments when lifting wire mesh screen used to prevent rock falls in underground mines.
AU - Gallagher, S.
AU - Kotowski, S.
AU - Davis, K. G.
AU - Mark, C.
AU - Compton, C. S.
AU - Huston, R. L.
AU - Connelly, J.
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2009///
VL - 39
IS - 5
SP - 828
EP - 834
CY - Oxford; UK
PB - Elsevier
SN - 0169-8141
AD - Gallagher, S.: National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA.
N1 - Accession Number: 20093243969. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Bolting large sheets of wire mesh screen (WMS) to the roof of underground mines prevents injuries due to rock falls. However, WMS can be heavy and awkward to lift and transport, and may result in significant spinal loading. Accordingly, six male subjects (mean age=45.8 years+7.5 SD) were recruited to lift WMS in a laboratory investigation of the biomechanical demands. Biomechanical modeling was used to estimate external moments about L5-S1 for sixteen lifting tasks, using two sizes of WMS. Full-size WMS involved a two-person lift, while half-size WMS involved a one-person lift. Lifts were performed under 168 cm and 213 cm vertical space. Restriction in vertical space increased the maximum L5-S1 extensor moment from 254 to 274 Nm and right lateral bending moment from 195 to 251 Nm. Lifting full sheets of screen (as opposed to half sheets) resulted in an average 33 Nm increase in L5-S1 extensor moment. The L5-S1 extensor moment was increased by an average of 44 Nm (18%) when lifting screens positioned flat on the floor compared to an upright position. Relevance to industry: Large flexible materials are commonly lifted in industrial work environments, and may involve the efforts of two or more workers. The current study examines the low back loading associated with lifting large flexible screens and presents recommendations to reduce spine loading.
KW - accidents
KW - joints (animal)
KW - mining
KW - occupational hazards
KW - occupational health
KW - physiology
KW - trauma
KW - traumas
KW - work safety
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Physiology and Biochemistry (VV050)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093243969&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V31-4VJJW5J-4&_user=10&_coverDate=09%2F30%2F2009&_rdoc=23&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235717%232009%23999609994%231420049%23FLA%23display%23Volume)&_cdi=5717&_sort=d&_docanchor=&_ct=33&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=42c1c41120573d318fb595852ce0eac5
UR - email: sfg9@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary.
AU - Reuter, G.
AU - Fodor, D.
AU - Forgách, P.
AU - Kátai, A.
AU - Szucs, G.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2009///
VL - 44
IS - 4
SP - 277
EP - 281
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Reuter, G.: Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, H-7623 Szabadság út 7, Pécs, Hungary.
N1 - Accession Number: 20093130390. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Veterinary Science; Public Health; Veterinary Science; Pig Science
N2 - Background: Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raising the possibility that HEV infection is also a zoonosis. Objectives/study design: Molecular detection and epidemiology of HEV in humans (South-East Hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by ELISA and RT-PCR. Results: Between 2001 and 2006, a total of 116 (9.6%) of 1203 human sera were positive by HEV IgM ELISA and 13 (24.5%) of 53 samples were also confirmed by RT-PCR and sequencing. Forty-two (27.3%) of 154, 11 (34.4%) of 32 and 9 (12.2%) of 74 samples were RT-PCR-positive from swine (feces: 22.7%; liver: 30.8%), roe-deer (liver) and wild boar (liver), respectively. Except for an imported infection caused by genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: 1, wild boar: 2) belong to genotype 3 HEV. Genetically identical strains were detected in human and roe-deer and in 2 other human clusters. Conclusions: HEV is an endemic agent in Hungary. Consumption of raw or undercooked meat-products is one of the possible sources of the indigenous HEV infections. Cross-species infection with genotype 3 HEV potentially involves a food-borne transmission route in Hungary.
KW - disease prevalence
KW - epidemiology
KW - genotypes
KW - hepatitis E
KW - human diseases
KW - liver
KW - liver diseases
KW - molecular epidemiology
KW - molecular genetics
KW - wild animals
KW - wild pigs
KW - zoonoses
KW - Hungary
KW - Capreolus capreolus
KW - cattle
KW - Hepatitis E virus
KW - man
KW - pigs
KW - Capreolus
KW - Cervidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Bos
KW - Bovidae
KW - Hepatitis E-like viruses
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - biochemical genetics
KW - hogs
KW - swine
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093130390&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/13866532
UR - email: reuter.gabor@baranya.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of a universal virus detection assay to identify human metapneumovirus in a hematopoietic stem cell transplant recipient with pneumonia of unknown origin.
AU - Uhlenhaut, C.
AU - Cohen, J. I.
AU - Fedorko, D.
AU - Nanda, S.
AU - Krause, P. R.
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2009///
VL - 44
IS - 4
SP - 337
EP - 339
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 1386-6532
AD - Uhlenhaut, C.: Division of Viral Products, Center for Biologics, Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892-4555, USA.
N1 - Accession Number: 20093130403. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 9007-49-2. Subject Subsets: Public Health
N2 - Background: Development of uncommon viral infections in immunocompromised transplant recipients can pose major diagnostic challenges. We present a case report of an immunocompromised patient suffering from pneumonia, for which the causative agent was not identified by routine methods. Objectives: To identify the potential cause of the pneumonia using a degenerate oligonucleotide primer (DOP)-PCR assay that is designed to detect all viruses. Study design: DOP-PCR was applied to bronchoalveolar lavage fluid from this patient. Generic PCR products were cloned and sequenced. Results: The novel universal virus assay detected human metapneumovirus in the clinical sample. The finding was confirmed by two independent metapneumovirus specific PCRs targeting different regions of the viral genome. Conclusions: The DOP-PCR was used to detect and identify the sequence of an unidentified virus. This study provides proof of concept for the use of clinically relevant specimens in this unbiased universal assay, which requires no previous viral sequence information.
KW - bone marrow cells
KW - bone marrow transplant
KW - case reports
KW - clinical aspects
KW - disease course
KW - DNA
KW - human diseases
KW - immunocompromised hosts
KW - opportunistic infections
KW - pneumonia
KW - polymerase chain reaction
KW - viral diseases
KW - man
KW - Metapneumovirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pneumovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - clinical picture
KW - deoxyribonucleic acid
KW - disease progression
KW - hematopoietic stem cell transplantation
KW - PCR
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093130403&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/13866532
UR - email: philip.krause@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Yersinia pseudotuberculosis YplA phospholipase differs in its activity, regulation and secretion from that of the Yersinia enterocolitica YplA.
AU - Meysick, K. C.
AU - Seidman, J.
AU - Falconio, J. R.
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2009///
VL - 47
IS - 1
SP - 24
EP - 32
CY - Oxford; UK
PB - Elsevier
SN - 0882-4010
AD - Meysick, K. C.: Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093198797. Publication Type: Journal Article. Language: English.
N2 - Analysis of the Yersinia pseudotuberculosis and Yersinia pestis genomes indicates that both species carry an identical copy of a gene that is predicted to encode a protein which shares 80% similarity to the Yersinia enterocolitica YplA, a secreted phospholipase that has been shown to contribute to virulence. In contrast to well tolerated production of the Y. enterocolitica YplA in Escherichia coli, Y. pseudotuberculosis YplA expression was found to be toxic; however, cell viability could be restored if the Y. pseudotuberculosis YplA was expressed in the presence of its accessory protein YplB. In vitro, Y. pseudotuberculosis YplB was shown to reduce the activity of its cognate phospholipase in a dose-dependent manner. To determine whether the Y. pseudotuberculosis and Y. enterocolitica YplAs were secreted and regulated in a similar manner, secretion and promoter activity assays were performed. Unlike the situation apparent in Y. enterocolitica, expression of the Y. pseudotuberculosis yplA gene did not appear to be controlled by the flagellar regulon, nor did the phospholipase appear to be efficiently exported through the flagellar apparatus. These results indicate that the Yersinia YplAs vary in many of their attributes despite their high degree of amino acid homology.
KW - enzymes
KW - virulence
KW - Yersinia enterocolitica
KW - Yersinia pseudotuberculosis
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - phospholipase
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093198797&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN6-4W6XVX5-2&_user=10&_coverDate=07%2F31%2F2009&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236954%232009%23999529998%231225055%23FLA%23display%23Volume)&_cdi=6954&_sort=d&_docanchor=&_ct=9&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=cda48fbf51e014b6efe16e957de843da
UR - email: karen.meysick@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract.
AU - Guo, L.
AU - Li, Q. Z.
AU - Xia, Q. S.
AU - Dial, S.
AU - Chan, P. C.
AU - Fu, P.
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
Y1 - 2009///
VL - 47
IS - 2
SP - 433
EP - 442
CY - Oxford; UK
PB - Elsevier
SN - 0278-6915
AD - Guo, L.: Division of Systems Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093082339. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 9035-51-2. Subject Subsets: Aromatic & Medicinal Plants; Crop Physiology
N2 - The association of kava product use with liver-related risks has prompted regulatory action in many countries. We studied the changes in gene expression of drug metabolizing enzymes in the livers of Fischer 344 male rats administered kava extract by gavage for 14 weeks. Analysis of 22,226 genes revealed that there were 14, 41, 110, 386, and 916 genes significantly changed in the 0.125, 0.25, 0.5, 1.0, and 2.0 g/kg treatment groups, respectively. There were 16 drug metabolizing genes altered in all three high-dose treatment groups, among which seven genes belong to cytochrome P450 isozymes. While gene expression of Cyp1a1, 1a2, 2c6, 3a1, and 3a3 increased; Cyp 2c23 and 2c40 decreased, all in a dose-dependent manner. Real-time PCR analyses of several genes verified these results. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb-drug interactions and may potentially lead to hepatotoxicity.
KW - cytochrome P-450
KW - enzymes
KW - gene expression
KW - genes
KW - liver
KW - medicinal plants
KW - medicinal properties
KW - polymerase chain reaction
KW - Alariaceae
KW - algae
KW - Ecklonia
KW - Laminariales
KW - rats
KW - plants
KW - aquatic plants
KW - aquatic organisms
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Laminariales
KW - Phaeophyta
KW - algae
KW - seaweeds
KW - Lessoniaceae
KW - drug plants
KW - Ecklonia cava
KW - medicinal herbs
KW - officinal plants
KW - PCR
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093082339&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02786915
UR - email: lei.guo@fda.hhs.gov\peter.fu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Individual susceptibility to cadmium toxicity and metallothionein gene polymorphisms: with references to current status of occupational cadmium exposure.
AU - Miura, N.
T3 - Special issue: Individual susceptibility to occupational hazard
JO - Industrial Health
JF - Industrial Health
Y1 - 2009///
VL - 47
IS - 5
SP - 487
EP - 494
CY - Kawasaki; Japan
PB - National Institute of Occupational Safety and Health
SN - 0019-8366
AD - Miura, N.: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20093320754. Publication Type: Journal Article. Note: Special issue: Individual susceptibility to occupational hazard Language: English. Number of References: 89 ref. Registry Number: 7440-43-9, 9038-94-2. Subject Subsets: Public Health
N2 - The incidence of serious poisoning caused by occupational cadmium exposure has declined over the past four decades due to improvements in the work environment. However, long-term low-level exposure to cadmium needs to be addressed. For workers in industries that handle cadmium, it is necessary to consider the daily cadmium intake from contaminated foods such as cereals and rice in addition to the occupational exposure, since workers might be exposed to higher levels of cadmium from a combination of these sources. Cadmium accumulates in the renal cortex by the long-term exposure along with increased concentrations of metallothionein, an important protein for protection from cadmium toxicity. However, some individuals have lower metallothionein levels despite increased cadmium accumulation in the kidneys. This article describes the strategy method for analyzing individual susceptibility to cadmium toxicity and genetic polymorphisms of metallothionein, with reference to the current status of occupational cadmium exposure.
KW - cadmium
KW - exposure
KW - genes
KW - genetic factors
KW - genetic polymorphism
KW - industrial wastes
KW - metallothionein
KW - occupational hazards
KW - occupational health
KW - poisoning
KW - toxicity
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - toxicosis
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093320754&site=ehost-live&scope=site
UR - http://www.jniosh.go.jp/en/indu_hel/index.html
UR - email: miuran@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Heart rate variability in occupational health - a systematic review.
AU - Togo, F.
AU - Takahashi, M.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009///
VL - 47
IS - 6
SP - 589
EP - 602
CY - Kawasaki; Japan
PB - National Institute of Occupational Safety and Health
SN - 0019-8366
AD - Togo, F.: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan.
N1 - Accession Number: 20103029639. Publication Type: Journal Article. Language: English. Number of References: 89 ref. Subject Subsets: Public Health
N2 - This systematic review evaluates and summarizes the evidence of association between work-related factors and heart rate variability (HRV) in workers. We reviewed English articles indexed in MEDLINE under the key words: work, worker, occupational, industrial, and heart rate variability. Studies were included if one or more of the dependent variables was one of the time- or frequency-domain indexes of HRV [standard deviation of all normal-to-normal (NN) intervals (SDNN), mean of the 5-min standard deviations of NN intervals calculated over several hours (SDNN index), the root mean squared differences of successive NN intervals (RMSSD), integrated spectral powers of high (HF, >0.15 Hz) and low frequency (LF, 0.04-0.15 Hz) HRV, and the LF/HF ratio] as recommended by the European Society of Cardiology and the North American Society of Pacing Electrophysiology. Physical and chemical work environments (i.e. exposure to occupational toxicants and hazardous environments), psychosocial workload (i.e. job stressors), and working time (i.e. shift work) had been examined and identified as having associations with low HF power. These findings may indicate that research into parasympathetic nervous system activity should be focused to protect cardiovascular health at work. We also propose the use of very low and ultralow frequency HRV components in autonomic research for workers' health.
KW - autonomic nervous system
KW - cardiovascular diseases
KW - exposure
KW - heart
KW - heart rate
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - shift work
KW - systematic reviews
KW - toxic substances
KW - work stress
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - parasympathetic system
KW - poisons
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103029639&site=ehost-live&scope=site
UR - http://www.jniosh.go.jp/en/indu_hel/index.html
UR - email: togo@h.jniosh.go.jp
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Resistance of Acanthamoeba cysts to disinfection in multiple contact lens solutions.
AU - Johnston, S. P.
AU - Sriram, R.
AU - Qvarnstrom, Y.
AU - Roy, S.
AU - Verani, J.
AU - Yoder, J.
AU - Lorick, S.
AU - Roberts, J.
AU - Beach, M. J.
AU - Visvesvara, G.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2009///
VL - 47
IS - 7
SP - 2040
EP - 2045
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Johnston, S. P.: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, NE, MS F-36, Atlanta, GA 30341-3724, USA.
N1 - Accession Number: 20093239729. Publication Type: Journal Article. Language: English. Number of References: 43 ref. Subject Subsets: Protozoology; Public Health
N2 - Acanthamoebae are free-living amoebae found in the environment, including soil, freshwater, brackish water, seawater, hot tubs, and Jacuzzis. Acanthamoeba species can cause keratitis, a painful vision-threatening infection of the cornea, and fatal granulomatous encephalitis in humans. More than 20 species of Acanthamoeba belonging to morphological groups I, II, and III distributed in 15 genotypes have been described. Among these, Acanthamoeba castellanii, A. polyphaga, and A. hatchetti are frequently identified as causing Acanthamoeba keratitis (AK). Improper contact lens care and contact with nonsterile water while wearing contact lenses are known risk factors for AK. During a recent multistate outbreak, AK was found to be associated with the use of Advanced Medical Optics Complete MoisturePlus multipurpose contact lens solution, which was hypothesized to have had insufficient anti-Acanthamoeba activity. As part of the investigation of that outbreak, we compared the efficacies of 11 different contact lens solutions against cysts of A. castellanii, A. polyphaga, and A. hatchetti (the isolates of all species were genotype T4), which were isolated in 2007 from specimens obtained during the outbreak investigation. The data, generated with A. castellanii, A. polyphaga, and A. hatchetti cysts, suggest that the two contact lens solutions containing hydrogen peroxide were the only solutions that showed any disinfection ability, with 0% and 66% growth, respectively, being detected with A. castellanii and 0% and 33% growth, respectively, being detected with A. polyphaga. There was no statistically significant difference in disinfection efficacy between the 11 solutions for A. hatchetti.
KW - contact lenses
KW - cysts (developmental stages)
KW - disinfection
KW - drug resistance
KW - free living amoebae
KW - human diseases
KW - keratitis
KW - outbreaks
KW - protozoal infections
KW - Acanthamoeba castellanii
KW - Acanthamoeba polyphaga
KW - man
KW - Acanthamoeba
KW - Acanthamoebidae
KW - Amoebida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Acanthamoeba hatchetti
KW - protozoal diseases
KW - Pesticide and Drug Resistance (HH410)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093239729&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: sjohnston@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Workplace violence intervention effectiveness: a systematic literature review.
AU - Wassell, J. T.
JO - Safety Science
JF - Safety Science
Y1 - 2009///
VL - 47
IS - 8
SP - 1049
EP - 1055
CY - Oxford; UK
PB - Elsevier
SN - 0925-7535
AD - Wassell, J. T.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road, M/S 1811, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093172064. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This is a systematic review of literature published since 1992, to determine the effectiveness of interventions in preventing workplace violence and to suggest interventions that need further evaluation research. The health care industry is the topic of 54% of the papers, the retail industry is the topic of 11% of the papers, and the remaining papers address the workplace in general or other situations. This finding drives the organization of this review: the first group of papers discussed in this review evaluates interventions to prevent workplace violence in the retail industry - mostly to prevent robbery and violence to retail workers. Singly or in combination, environmental designs in the retail industry, such as increased lighting to improve visibility and a limited cash-handling policy, can make workers safer, but more research is needed to overcome the barriers to implementation of environmental designs, especially in small businesses. The second group of papers in this review is about interventions to prevent violence to health care workers - mostly training and techniques of dealing with combative patients. Training health care workers to better cope with violent patients and to avoid injury is becoming standard practice, but research is needed to identify specific aspects of training and patient management programs that are most effective.
KW - aggressive behaviour
KW - behaviour
KW - health care
KW - health care workers
KW - occupational health
KW - reviews
KW - work places
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - aggressive behavior
KW - behavior
KW - Health Services (UU350)
KW - Conflict (UU495) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093172064&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VF9-4V9YNNF-2&_user=10&_coverDate=10%2F31%2F2009&_rdoc=2&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236005%232009%23999529991%231130345%23FLA%23display%23Volume)&_cdi=6005&_sort=d&_docanchor=&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=49629f4cdde9bbef81888ac981372ff4
UR - email: JWassell@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Consensus amplification and novel multiplex sequencing method for S segment species identification of 47 viruses of the Orthobunyavirus, Phlebovirus, and Nairovirus genera of the family Bunyaviridae.
AU - Lambert, A. J.
AU - Lanciotti, R. S.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2009///
VL - 47
IS - 8
SP - 2398
EP - 2404
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Lambert, A. J.: Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampart Rd., Fort Collins, CO 80521, USA.
N1 - Accession Number: 20093260793. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Registry Number: 9007-49-2, 63231-63-0. Subject Subsets: Public Health; Medical & Veterinary Entomology
N2 - A reverse transcription-PCR (RT-PCR) assay was designed, according to previously determined and newly derived genetic data, to target S genomic segments of 47 viruses, including 29 arthropod-borne human pathogens, of the family Bunyaviridae. The analytical sensitivity of the presented assay was evaluated through its application to RNAs extracted from quantitated dilutions of bunyaviruses of interest. Additionally, the assay's analytical specificity was determined through the evaluation of RNAs extracted from selected bunyaviruses and other representative arthropod-borne viruses isolated from a diverse group of host species and temporal and geographic origins. After RT-PCR amplification, DNAs amplified from bunyaviruses of interest were subjected to a novel multiplex sequencing method to confirm bunyavirus positivity and provide preliminary, species-level S segment identification. It is our goal that this assay will be used as a tool for identification and characterization of emergent arthropod-borne bunyavirus isolates of medical import as well as related viruses of the family Bunyaviridae that have not been associated with human illness.
KW - arboviruses
KW - DNA
KW - genes
KW - genomes
KW - methodology
KW - molecular genetics
KW - reverse transcriptase PCR
KW - RNA
KW - Bunyaviridae
KW - Nairovirus
KW - Phlebovirus
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Bunyaviridae
KW - arthropod-borne viruses
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - methods
KW - reverse transcriptase polymerase chain reaction
KW - ribonucleic acid
KW - RT-PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093260793&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: ahk7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of toll-like receptor assays to detect and identify microbial contaminants in biological products.
AU - Huang, L. Y.
AU - DuMontelle, J. L.
AU - Zolodz, M.
AU - Deora, A.
AU - Mozier, N. M.
AU - Golding, B.
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
Y1 - 2009///
VL - 47
IS - 11
SP - 3427
EP - 3434
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0095-1137
AD - Huang, L. Y.: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-345, Rockville, MD 20852, USA.
N1 - Accession Number: 20103021259. Publication Type: Journal Article. Language: English. Number of References: 28 ref. Subject Subsets: Public Health
N2 - Toll-like receptor (TLR)-expressing cells, for the first time, detected and identified a microbial contaminant in a product made in Escherichia coli using an old manufacturing process. It was suspected of having a microbial contaminant(s) because, although it tested negative by standard pyrogen assays, it was associated with adverse events in early clinical trials. The assay readout is the induction of NF-κB and/or cytokines in response to TLR activation. Four coded samples, labeled A to D, including a sample prepared by the older manufacturing process, were submitted. The cell lines were activated only by samples B and D. Sample D stimulated only Mono-Mac 6 and HEK-human TLR4 (hTLR4) cells and was later identified as lipopolysaccharide. Except for TLR3 cells, sample B stimulated cells bearing the different TLRs (TLRs 2, 4, 5, 7, 8, and 9) and nontransfected HEK293 cells. These data suggested that flagellin was the microbial contaminant, since TLR5, the receptor for flagellin, is known to be expressed constitutively on HEK293 cells. Moreover, purified flagellin from Salmonella enterica serovar Typhimurium behaved like sample B, stimulating HEK293 and HEK-hTLR5 cells but not HEK-hTLR3 cells, and this stimulation by flagellin and sample B was blocked by an anti-hTLR5 neutralizing antibody. Western blots showed bands positive for flagellin and sample B with the molecular sizes expected for the flagellins from S. Typhimurium and E. coli, respectively. Mass spectrometry data were consistent with the presence of flagellin in the manufacturer's sample B. Taken together, these data indicate that the microbial contaminant in sample B was flagellin and may have been associated with adverse events when the recombinant product was administered.
KW - assays
KW - biochemical receptors
KW - cell lines
KW - detection
KW - lipopolysaccharides
KW - microbial contamination
KW - recombinant proteins
KW - transcription factors
KW - Escherichia coli
KW - Salmonella Typhimurium
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - bacterium
KW - biological products
KW - E. coli
KW - flagellin
KW - NF-kappa B
KW - toll-like receptors
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103021259&site=ehost-live&scope=site
UR - http://jcm.asm.org/
UR - email: basil.golding@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Babesia infection through blood transfusions: reports received by the US food and drug administration, 1997-2007.
AU - Gubernot, D. M.
AU - Lucey, C. T.
AU - Lee, K. C.
AU - Conley, G. B.
AU - Holness, L. G.
AU - Wise, R. P.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009///
VL - 48
IS - 1
SP - 25
EP - 30
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Gubernot, D. M.: Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093014370. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology; Public Health
N2 - Background. Human babesiosis is an illness with clinical manifestations that range from asymptomatic to fatal. Although babesiosis is not nationally notifiable, the US incidence appears to be increasing. Babesia infection is a transfusion-transmissible disease. An estimated 70 cases were reported during 1979-2007; most of these cases were reported during the past decade. Methods. We queried the 3 following US Food and Drug Administration safety surveillance systems to assess trends in babesiosis reporting since 1997: fatality reports for blood donors and transfusion recipients, the Adverse Event Reporting System (which includes MedWatch), and the Biological Product Deviations Reporting system. We analyzed fatality reports for time frames, clinical presentations, and patient and donor demographic characteristics. Results. Eight of 9 deaths due to transfusion-transmitted babesiosis that were reported since 1997 occurred within the past 3 years (2005-2007). Four implicated donors and 5 patients lived in areas where Babesia infection is not endemic. Increasing numbers of Biological Product Deviations Reports were submitted to the US Food and Drug Administration over the past decade; the Adverse Event Reporting System received no reports. Conclusions. After nearly a decade with no reported death due to transfusion-transmitted babesiosis, the US Food and Drug Administration received 8 reports from November 2005 onward. The increased numbers of deaths reported and Biological Product Deviations Reports suggest an increasing incidence of transfusion-transmitted babesiosis. Physicians should consider babesiosis in the differential diagnosis in immunocompromised, febrile patients with a history of recent transfusion, even in areas where Babesia infection is not endemic. Accurate and timely reporting of babesiosis-related donor and transfusion events assists the US Food and Drug Administration in developing appropriate public health-control measures.
KW - babesiosis
KW - blood donors
KW - blood transfusion
KW - disease transmission
KW - human diseases
KW - mortality
KW - USA
KW - Babesia
KW - man
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - red water
KW - tick fever
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093014370&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/595010
UR - email: diane.gubernot@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measurement of airborne influenza virus in a hospital emergency department.
AU - Blachere, F. M.
AU - Lindsley, W. G.
AU - Pearce, T. A.
AU - Anderson, S. E.
AU - Fisher, M.
AU - Khakoo, R.
AU - Meade, B. J.
AU - Lander, O.
AU - Davis, S.
AU - Thewlis, R. E.
AU - Celik, I.
AU - Chen, B. T.
AU - Beezhold, D. H.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009///
VL - 48
IS - 4
SP - 438
EP - 440
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Blachere, F. M.: Division of Health Effects Laboratory, National Institute for Occupational Safety and Health, West Virginia University, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
N1 - Accession Number: 20093069614. Publication Type: Journal Article. Language: English. Number of References: 14 ref. Subject Subsets: Public Health
N2 - Size-fractionated aerosol particles were collected in a hospital emergency department to test for airborne influenza virus. Using real-time polymerase chain reaction, we confirmed the presence of airborne influenza virus and found that 53% of detectable influenza virus particles were within the respirable aerosol fraction. Our results provide evidence that influenza virus may spread through the airborne route.
KW - aerosols
KW - air
KW - hospitals
KW - influenza viruses
KW - microbial contamination
KW - USA
KW - West Virginia
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - United States of America
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093069614&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/596478
UR - email: FBlachere@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs.
AU - Reepmeyer, J. C.
AU - d'Avignon, D. A.
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
Y1 - 2009///
VL - 49
IS - 1
SP - 145
EP - 150
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0731-7085
AD - Reepmeyer, J. C.: US Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA.
N1 - Accession Number: 20093096741. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Two analogues of sildenafil were detected in herbal dietary supplements marketed as aphrodisiacs. Both compounds were identified as thioketone analogues of sildenafil in which the carbonyl group in the pyrimidine ring of sildenafil was substituted with a thiocarbonyl group. The first compound was identified as thiosildenafil, a compound that has recently been reported as an adulterant in health supplements. The structure of the second compound was established using LC-MS, UV spectroscopy, ESI-MSn, NMR and a hydrolytic process. A detailed study of the hydrolysis products of sildenafil, thiosildenafil, and the second unknown compound proved that the second compound, named thiomethisosildenafil, had a structure analogous to sildenafil in which the N-methylpiperazine moiety had been replaced with 2,6-dimethylpiperazine and the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom. Under the hydrolytic reaction conditions employed in this study, thioketones hydrolyze to ketones (e.g., thiosildenafil -> sildenafil), making this a valuable technique for the structure elucidation of thiosildenafil analogues. Ten herbal dietary supplements, each as a capsule dosage form, were found to contain 8-151 mg of thiomethisosildenafil per capsule, and one herbal dietary supplement was found to contain 35 mg of thiosildenafil per capsule.
KW - chemical composition
KW - herbal drugs
KW - ketones
KW - medicinal properties
KW - plant extracts
KW - herbal medicines
KW - Non-food/Non-feed Plant Products (SS200)
KW - Composition and Quality of Non-food/Non-feed Plant Products (SS230)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093096741&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/07317085
UR - email: john.reepmeyer@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nested real-time PCR for hepatitis A detection.
AU - Hu, Y.
AU - Arsov, I.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2009///
VL - 49
IS - 5
SP - 615
EP - 619
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0266-8254
AD - Hu, Y.: U.S. Food and Drug Administration, Northeast Regional Laboratory, Microbiological Sciences Branch, 158-15 Liberty Avenue, Jamaica, NY 11433, USA.
N1 - Accession Number: 20093303538. Publication Type: Journal Article. Language: English. Number of References: 18 ref. Subject Subsets: Human Nutrition; Public Health
N2 - Aims: The hepatitis A virus (HAV) is one of the most important human foodborne pathogens causing a number of worldwide outbreaks each year. The detection of HAV in food samples remains a complex issue, because commonly used detection tools, such as conventional or even real-time PCR assays, are often unable to detect HAV with sufficient sensitivity. The aims of this study were to develop highly sensitive and specific nested real-time PCR (NRT-PCR)-based method for HAV detection in food and to compare it with currently available methods. Methods and Results: By combining conventional PCR, nested PCR and real-time PCR techniques, we have developed a specific NRT-PCR assay for the detection of HAV. The procedure involves two consecutive PCRs, the first of which is performed as a conventional RT-PCR using primers specific for HAV 5′ noncoding region. The second reaction involves a real-time PCR using a nested primer pair specific for the first PCR product and a TaqMan probe. Conclusions: We have developed a novel NRT-PCR method capable of detecting as little as 0.2 PFU of HAV, which is significantly more sensitive than any other PCR technique tested in our system. Significance and Impact of the Study: NRT-PCR provides a potentially useful method for detecting HAV at extremely low levels, as frequently found in food samples, and can be potentially adopted as a regulatory method to ensure food safety.
KW - accuracy
KW - analytical methods
KW - disease prevalence
KW - epidemiology
KW - food contamination
KW - food hygiene
KW - food safety
KW - foodborne diseases
KW - hepatitis A
KW - human diseases
KW - outbreaks
KW - polymerase chain reaction
KW - Hepatitis A virus
KW - man
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - food contaminants
KW - PCR
KW - Techniques and Methodology (ZZ900)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093303538&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/lam
UR - email: yuan.hu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Quantitative estimate of the risks and benefits of possible alternative blood donor deferral strategies for men who have had sex with men.
AU - Anderson, S. A.
AU - Yang Hong
AU - Gallagher, L. M.
AU - O'Callaghan, S.
AU - Forshee, R. A.
AU - Busch, M. P.
AU - McKenna, M. T.
AU - Williams, I.
AU - Williams, A.
AU - Kuehnert, M. J.
AU - Stramer, S.
AU - Kleinman, S.
AU - Epstein, J.
AU - Dayton, A. I.
JO - Transfusion
JF - Transfusion
Y1 - 2009///
VL - 49
IS - 6
SP - 1102
EP - 1114
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Anderson, S. A.: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.
N1 - Accession Number: 20093182564. Publication Type: Journal Article. Language: English. Number of References: 59 ref. Subject Subsets: Public Health
N2 - BACKGROUND: Implementation of sensitive screening methods for human immunodeficiency virus (HIV) and hepatitis viruses prompts the question of what quantitative risks may result from altered deferral strategies for donation of blood by men who have had sex with men (MSM). STUDY DESIGN AND METHODS: Quantitative probabilistic models were developed to assess changes in the residual risk of transfusion-transmitted HIV and hepatitis B virus (HBV) associated with blood testing and quarantine release errors (QREs) in the initial year of two hypothetical policy scenarios that would allow donations from donors who have abstained from MSM behavior for at least 5 years (MSM5) or at least 1 year (MSM1). RESULTS: The MSM5 and MSM1 models, respectively, predicted annual increases in units of HIV-infected blood of 0.5% (0.03 mean additional units; 95% confidence interval [CI], 0-1) and 3.0% (0.18 mean additional units; 95% CI, 0-1) over current estimated HIV residual risk using recent, nationwide biologic product deviation reports to estimate QRE rates. These estimates are approximately 10-fold lower than estimates based on New York State QRE data from the previous decade. The models predicted smaller increases in infectious HBV donations. CONCLUSIONS: QREs remain the most significant preventable source of risk. More accurate inputs, including the percentage of MSM in the population, the percentage of MSM who have abstained from MSM activity for 1 or 5 years, the prevalence of HIV and HBV in MSM who have abstained from MSM activity for 1 or 5 years, the rate of self-deferral, and QRE rates, are required before making more precise predictions.
KW - blood donors
KW - blood transfusion
KW - hepatitis B
KW - HIV infections
KW - homosexuality
KW - human diseases
KW - Human immunodeficiency viruses
KW - men
KW - quantitative analysis
KW - risk
KW - risk assessment
KW - sexual behaviour
KW - USA
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - homosexuals
KW - human immunodeficiency virus infections
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - transfusion-transmitted virus
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093182564&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/trf
UR - email: andrew.dayton@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Methicillin-resistant Staphylococcus aureus-associated hospitalizations among the American Indian and Alaska Native population.
AU - Byrd, K. K.
AU - Holman, R. C.
AU - Bruce, M. G.
AU - Hennessy, T. W.
AU - Wenger, J. D.
AU - Bruden, D. L.
AU - Haberling, D. L.
AU - Steiner, C.
AU - Cheek, J. E.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009///
VL - 49
IS - 7
SP - 1009
EP - 1015
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Byrd, K. K.: Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention (CDC), United States Department of Health and Human Services (USDHHS), 1600 Clifton Rd NE, Mailstop G-37, Atlanta, GA 30333, USA.
N1 - Accession Number: 20093267941. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Registry Number: 61-32-5. Subject Subsets: Public Health
N2 - Background. American Indians and Alaska Natives (AI/ANs) have had documented outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) infection but, to our knowledge, no studies have examined MRSA infection among this population nationally. We describe MRSA-associated hospitalizations among the ~1.6 million AI/ANs who receive care at Indian Health Service health care facilities nationwide. Methods. We used hospital discharge data from the Indian Health Service National Patient Information Reporting System to determine the rate of MRSA-associated hospitalizations among AI/ANs who used Indian Health Service health care in 1996-2005 and in the comparison periods 1996-1998 and 2003-2005. Hospitalization rates among AI/ANs were examined by year, age group, sex, and region. MRSA-associated diagnoses were also examined. Rate comparisons were performed using Poisson regression analysis. Comparison of rates to those of the general United States population was made for 2003-2005 by means of the Nationwide Inpatient Sample. Results. Between comparison periods, the rate of MRSA-associated hospitalization increased from 4.6 to 50.6 hospitalizations per 100,000 AI/ANs (P<.01), with increases in both sexes, all age groups, and all regions. By 2005, MRSA was the causative organism for the majority (52%) of all S. aureus-associated hospitalizations. The most common associated diagnosis was skin and soft-tissue infection, which accounted for 59% of MRSA-associated diagnoses. In 2003-2005, the age-adjusted rate among AI/ANs was 58.8 hospitalizations per 100,000 persons, compared with 84.7 hospitalizations per 100,000 persons in the general US population. Conclusions. MRSA-associated hospitalizations have increased significantly among AI/ANs served by Indian Health Service health care facilities. Clinicians should have a high index of suspicion for MRSA infection in AI/ANs, especially in those with a diagnosis of skin and soft-tissue infection.
KW - American indians
KW - antibacterial agents
KW - bacterial diseases
KW - drug resistance
KW - epidemiology
KW - human diseases
KW - Inuit
KW - methicillin
KW - morbidity
KW - man
KW - Staphylococcus aureus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - Eskimos
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093267941&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/605560
UR - email: gdn8@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infectious disease hospitalizations in the United States.
AU - Christensen, K. L. Y.
AU - Holman, R. C.
AU - Steiner, C. A.
AU - Sejvar, J. J.
AU - Stoll, B. J.
AU - Schonberger, L. B.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009///
VL - 49
IS - 7
SP - 1025
EP - 1035
CY - Chicago; USA
PB - University of Chicago Press
SN - 1058-4838
AD - Christensen, K. L. Y.: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, MS A-39, Atlanta, Georgia, USA.
N1 - Accession Number: 20093267943. Publication Type: Journal Article. Language: English. Number of References: 34 ref. Subject Subsets: Public Health
N2 - Background. Infectious diseases (IDs) cause widespread morbidity and mortality. We describe the epidemiology of ID hospitalizations in the United States with use of a nationally representative database. Methods. First-listed ID hospitalizations in the United States were analyzed using the Nationwide Inpatient Sample for 1998-2006. Hospitalization rates were calculated overall for IDs and for specific ID groups. Results. An estimated 40,085,978 (standard error, 255,418) hospitalizations with a first-listed ID occurred during 1998-2006, for an age-adjusted hospitalization rate of 154.4 (95% confidence interval, 153.3-155.5) hospitalizations per 10,000 persons. The rate increased slightly over the study period (152.5 [95% confidence interval, 149.6-155.4] in 1998 vs 162.2 [95% confidence interval, 158.7-165.5] in 2006); an increase was seen for both sexes, for older patients, and for Hispanic patients. Among those aged 5-39 years, female patients had a significantly higher hospitalization rate than did male patients; male patients had higher rates among the youngest children and adults aged ≥40 years. Approximately 4.5 million hospital days and $865 billion in hospital charges were associated with primary ID hospitalizations over the study period. Lower respiratory tract infections were the most commonly listed ID (34.4%), followed by kidney, urinary tract, and bladder infections; cellulitis; and abdominal and rectal infections. Conclusions. The ID hospitalization rate increased during 1998-2006, reflecting an increase in ID hospitalizations among adults aged ≥30 years, particularly older adults. Differences in trends and patterns of ID hospitalizations were noted by sex, age group, and race. Lower respiratory tract infections accounted for the largest proportion of ID hospitalizations. Future efforts should focus on preventive measures and improving early interventions for IDs.
KW - epidemiology
KW - human diseases
KW - infections
KW - infectious diseases
KW - morbidity
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - communicable diseases
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093267943&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/605562
UR - email: KYorita@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transfusion-transmitted babesiosis in the United States: summary of a workshop.
AU - Gubernot, D. M.
AU - Nakhasi, H. L.
AU - Mied, P. A.
AU - Asher, D. M.
AU - Epstein, J. S.
AU - Kumar, S.
JO - Transfusion
JF - Transfusion
Y1 - 2009///
VL - 49
IS - 12
SP - 2759
EP - 2771
CY - Boston; USA
PB - Blackwell Publishing
SN - 0041-1132
AD - Gubernot, D. M.: Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.
N1 - Accession Number: 20103011377. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health; Protozoology; Medical & Veterinary Entomology
N2 - Infections of humans with intraerythrocytic parasites of the genus Babesia can be locally prevalent in diverse regions of the United States. Transfusion of blood and blood products collected from donors infected with Babesia may result in a serious illness that can be fatal. In September 2008, the Food and Drug Administration organized a public workshop to discuss the various aspects of transfusion-transmitted babesiosis in the United States including the possible strategies to identify and defer blood donors who may have been infected with Babesia. Discussions were also held on the biology, pathogenesis, and epidemiology of Babesia species. In this article, we summarize the scientific presentations and panel discussions that took place during the workshop.
KW - babesiosis
KW - blood donors
KW - blood transfusion
KW - disease transmission
KW - human diseases
KW - tickborne diseases
KW - USA
KW - Babesia microti
KW - man
KW - Babesia
KW - Babesiidae
KW - Piroplasmorida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - red water
KW - tick fever
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Non-drug Therapy and Prophylaxis of Humans (VV710) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103011377&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/trf
UR - email: sanjai.kumar@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
AU - Pogribny, I. P.
AU - Tryndyak, V. P.
AU - Bagnyukova, T. V.
AU - Melnyk, S.
AU - Montgomery, B.
AU - Ross, S. A.
AU - Latendresse, J. R.
AU - Rusyn, I.
AU - Beland, F. A.
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009///
VL - 51
IS - 1
SP - 176
EP - 186
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-8278
AD - Pogribny, I. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093182683. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Background/Aims: The importance of epigenetic changes in etiology and pathogenesis of disease has been increasingly recognized. However, the role of epigenetic alterations in the genesis of hepatic steatosis and cause of individual susceptibilities to this pathological state are largely unknown. Methods: Male inbred C57BL/6J and DBA/2J mice were fed a lipogenic methyl-deficient diet (MDD) that causes liver injury similar to human non-alcoholic steatohepatitis (NASH) for 6, 12, or 18 weeks, and the status of global and repetitive elements cytosine methylation, histone modifications, and expression of proteins responsible for those epigenetic modifications in livers was determined. Results: The development of hepatic steatosis in inbred C57BL/6J and DBA/2J mice was accompanied by prominent epigenetic abnormalities. This was evidenced by pronounced loss of genomic and repetitive sequences cytosine methylation, especially at major and minor satellites, accompanied by increased levels of repeat-associated transcripts, aberrant histone modifications, and alterations in expression of the maintenance DNA methyltransferase 1 (DNMT1) and de novo DNMT3A proteins in the livers of both mouse strains. However, the DBA/2J mice, which were characterized by an initially lower degree of methylation of repetitive elements and lower extent of histone H3 lysine 9 (H3K9) and H3 lysine 27 (H3K27) trimethylation in the normal livers, as compared to those in the C57BL/6J mice, developed more prominent NASH-specific pathomorphological changes. Conclusions: These results mechanistically link epigenetic alterations to the pathogenesis of hepatic steatosis and strongly suggest that differences in the cellular epigenetic status may be a predetermining factor to individual susceptibilities to hepatic steatosis.
KW - animal models
KW - fatty liver
KW - human diseases
KW - laboratory animals
KW - liver diseases
KW - pathogenesis
KW - susceptibility
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - disease susceptibility
KW - fatty liver disease
KW - fatty liver syndrome
KW - steatosis
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093182683&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7C-4W6VRT1-1&_user=10&_coverDate=07%2F31%2F2009&_rdoc=26&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236623%232009%23999489998%231164052%23FLA%23display%23Volume)&_cdi=6623&_sort=d&_docanchor=&_ct=37&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5db831569f8ab01ed8ebbcdec72621bd
UR - email: igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Frequent HCV reinfection and superinfection in a cohort of injecting drug users in Amsterdam.
AU - Laar, T. J. W. van de
AU - Molenkamp, R.
AU - Berg, C. van den
AU - Schinkel, J.
AU - Beld, M. G. H. M.
AU - Prins, M.
AU - Coutinho, R. A.
AU - Bruisten, S. M.
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009///
VL - 51
IS - 4
SP - 667
EP - 674
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-8278
AD - Laar, T. J. W. van de: Cluster of Infectious Diseases, Public Health Service, Nieuwe Achtergracht 100, 1018 WT Amsterdam, Netherlands.
N1 - Accession Number: 20093281199. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Background/Aims - This study investigates the occurrence of HCV reinfection and superinfection among HCV seroconverters participating in the Amsterdam Cohort Studies among drug users from 1985 through 2005. Methods - HCV seroconverters (n=59) were tested for HCV RNA at five different time points: the last visit before seroconversion (t=-1), the first visit after seroconversion (t=1), six months after (t=2) and one year after (t=3) seroconversion, and the last visit prior to November 2005 (t=4). If HCV RNA was present, part of the NS5B region was amplified and sequenced. Additional phylogenetic analysis and cloning was performed to establish HCV reinfection and superinfection. Results - Multiple HCV infections were detected in 23/59 (39%) seroconverters; 7 had HCV reinfections, 14 were superinfected, and 2 had reinfection followed by superinfection. At the moment of HCV reinfection, 7/9 seroconverters were HIV-negative: persistent HCV reinfection developed in both HIV-positive cases but also in 4/7 HIV-negative cases. In total, we identified 93 different HCV infections, varying from 1 to 4 infections per seroconverter. Multiple HCV infections were observed in 10/24 seroconverters with spontaneous HCV clearance (11 reinfections, 3 superinfections) and in 13/35 seroconverters without viral clearance (20 superinfections). Conclusions - HCV reinfection and superinfection are common among actively injecting drug users. This might further complicate the development of an effective HCV vaccine.
KW - behaviour
KW - hepatitis C
KW - human diseases
KW - injecting drug abuse
KW - injecting drug users
KW - risk behaviour
KW - risk factors
KW - risk groups
KW - Netherlands
KW - Hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - behavior
KW - i.v. drug abuse
KW - i.v. drug abusers
KW - i.v. drug use
KW - i.v. drug users
KW - intravenous drug users
KW - risk behavior
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093281199&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7C-4WJGDCK-2&_user=10&_coverDate=10%2F31%2F2009&_rdoc=18&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236623%232009%23999489995%231493102%23FLA%23display%23Volume)&_cdi=6623&_sort=d&_docanchor=&_ct=44&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bb39d9bec1e6e05f936a1d9646d72f59
UR - email: tvdlaar@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
AU - Fleischer, R. D.
AU - Lok, A. S. F.
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009///
VL - 51
IS - 4
SP - 787
EP - 791
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-8278
AD - Fleischer, R. D.: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20093281204. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - The development of clevudine as a treatment for hepatitis B was terminated recently because of case reports of myopathy. In each case, the onset of symptoms occurred between 8 and 13 months after the initiation of treatment. Electromyography and muscle biopsy confirmed the presence of myonecrosis. One report also found evidence of mitochondrial toxicity. The delayed onset and the finding of mitochondrial damage are reminiscent of fialuridine toxicity. Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon. These findings serve as a sober reminder of the lack of data on long-term safety of nucleos(t)ide analogs for hepatitis B, the importance of balancing benefits versus risks before initiating treatment, and the need for more stringent post-marketing surveillance for drug toxicities.
KW - adverse effects
KW - antiviral agents
KW - clinical aspects
KW - drug therapy
KW - hepatitis B
KW - human diseases
KW - muscular diseases
KW - nervous system diseases
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - adverse reactions
KW - chemotherapy
KW - clinical picture
KW - myopathy
KW - neuropathy
KW - telbivudine
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093281204&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7C-4WN83PB-1&_user=10&_coverDate=10%2F31%2F2009&_rdoc=31&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236623%232009%23999489995%231493102%23FLA%23display%23Volume)&_cdi=6623&_sort=d&_docanchor=&_ct=44&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dc335583d3f33aa420c27828bfee2dff
UR - email: aslok@umich.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Probiotic bacteria are antagonistic to Salmonella enterica and Campylobacter jejuni and influence host lymphocyte responses in human microbiota-associated immunodeficient and immunocompetent mice.
AU - Wagner, R. D.
AU - Johnson, S. J.
AU - Rubin, D. K.
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
Y1 - 2009///
VL - 53
IS - 3
SP - 377
EP - 388
CY - Weinheim; Germany
PB - WILEY-VCH Verlag GMBH & Co. KGaA
SN - 1613-4125
AD - Wagner, R. D.: Microbiology Division, HFT-250, National Center for Toxicological Research, USFDA, 3900 NCTR Rd., Jefferson, AR 72079, USA.
N1 - Accession Number: 20093103579. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Subject Subsets: Dairy Science
N2 - A defined human microbiota-associated (HMA) mouse model in BALB/c and immunodeficient Tg 26 mice was used to assess the ability of probiotic lactobacilli and bifidobacteria to enhance colonization resistance to gastrointestinal (GI) tract pathogens. Probiotic bacteria (1×108 colony forming unit (CFU)/mL) successfully excluded Campylobacter jejuni from both strains of mice 7 days after challenge. The probiotic bacteria also reduced the number of Salmonella in the large intestines of both mouse strains. The nylon wool fractionated spleen lymphocyte populations were incubated with Salmonella or C. jejuni antigens. The probiotic treatments did not affect lymphocyte proliferation to C. jejuni antigens, but significantly increased proliferation of lymphocytes to Salmonella antigens by 68 and 55%, respectively, over untreated mice. Caspase 3/7 activation was significantly reduced 33 and 38% in the T and B lymphocyte fractions, respectively, of probiotic-treated, Salmonella-challenged HMA BALB/c mice, suggesting that lymphocyte rescue from apoptosis was occurring as a result of probiotic bacteria activity. These results revealed an immunosuppressive activity by Salmonella that was inhibited by the presence of probiotic bacteria. In summary, lactobacilli and bifidobacteria competitively excluded C. jejuni from immunocompetent and immunodeficient mice and antagonized an observable Salmonella-induced immunosuppression in immunocompetent mice.
KW - animal models
KW - antibacterial properties
KW - campylobacteriosis
KW - immune competence
KW - immune response
KW - immunological deficiency
KW - intestinal microorganisms
KW - laboratory animals
KW - lactic acid bacteria
KW - lymphocytes
KW - probiotics
KW - salmonellosis
KW - Bifidobacterium
KW - Campylobacter jejuni
KW - Lactobacillus
KW - mice
KW - Salmonella enterica
KW - Bifidobacteriaceae
KW - Bifidobacteriales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - Campylobacter
KW - Campylobacteraceae
KW - Campylobacterales
KW - Epsilonproteobacteria
KW - Proteobacteria
KW - Lactobacillaceae
KW - Lactobacillales
KW - Bacilli
KW - Firmicutes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - bactericidal properties
KW - bacterium
KW - gut flora
KW - immune deficiency
KW - immunity reactions
KW - immunocompetence
KW - immunodeficiency
KW - immunological competence
KW - immunological reactions
KW - intestinal micro-organisms
KW - Salmonella infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Animal Models of Human Nutrition (VV140)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093103579&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/109582333/home
UR - email: doug.wagner@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Allergen databases and allergen semantics.
AU - Gendel, S. M.
A2 - Embry, M.
A2 - Gibson, J. E.
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
Y1 - 2009///
VL - 54
IS - 3, Suppl. 1
SP - S7
EP - S10
CY - New York; USA
PB - Elsevier
SN - 0273-2300
AD - Gendel, S. M.: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093229487. Publication Type: Journal Article; Conference paper. Language: English. Subject Subsets: Public Health; Human Nutrition
N2 - The efficacy of any specific bioinformatic analysis of the potential allergenicity of new food proteins depends directly on the nature and content of the databases that are used in the analysis. A number of different allergen-related databases have been developed, each designed to meet a different need. These databases differ in content, organization, and accessibility. These differences create barriers for users and prevent data sharing and integration. The development and application of appropriate semantic web technologies, (for example, a food allergen ontology) could help to overcome these barriers and promote the development of more advanced analytic capabilities.
KW - allergens
KW - allergies
KW - databases
KW - food allergies
KW - human diseases
KW - proteins
KW - data banks
KW - food hypersensitivity
KW - Information and Documentation (CC300)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093229487&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPT-4V3545V-1&_user=10&_coverDate=08%2F31%2F2009&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236999%232009%23999459996.8998%231320083%23FLA%23display%23Volume)&_cdi=6999&_sort=d&_docanchor=&_ct=14&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d56d768c284efb6ed118d7ec2e8c1b66
UR - email: steven.gendel@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Psychological distress and mental health treatment among persons with and without active duty military experience, Behavioral Risk Factor Surveillance System, United States, 2007.
AU - Safran, M. A.
AU - Strine, T. W.
AU - Dhingra, S. S.
AU - Berry, J. T.
AU - Manderscheid, R.
AU - Mokdad, A. H.
JO - International Journal of Public Health
JF - International Journal of Public Health
Y1 - 2009///
VL - 54
IS - suppl. 1
SP - 61
EP - 67
CY - Basel; Switzerland
PB - Birkhäuser Verlag AG
SN - 1661-8556
AD - Safran, M. A.: CAPT, U.S. Public Health Service, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop E-44, Atlanta, GA 30333, USA.
N1 - Accession Number: 20093184469. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - Objectives: To examine self-reported psychological distress (K-6 scale) and mental health treatment among persons with and without active duty U.S. military experience (ADME) currently residing in private residences in the U.S. Methods: Analysis of 2007 Behavioral Risk Factor Surveillance System data from 35 states, District of Columbia, and Puerto Rico (n=202,029 for those answering all K-6 questions, the treatment question, and the ADME question) Results: Adjusting for age, sex, race/ethnicity, and education, overall mean K-6 scores of those with and without ADME were similar (p=0.3223); however, more of those with, vs. without, ADME reported current mental health treatment (11.7% vs. 9.6%, p=0.0001). Those with ADME receiving such treatment had a higher mean K-6 score (7.7) than those without ADME receiving such treatment (6.9) (p=0.0032). Conclusions: Community-dwelling persons with ADME have similar demographically-adjusted mean K-6 psychological distress scores, but greater likelihood of recent mental health treatment, compared to those without ADME.
KW - adults
KW - behaviour
KW - human diseases
KW - mental disorders
KW - mental health
KW - military personnel
KW - risk factors
KW - surveillance
KW - District of Columbia
KW - Puerto Rico
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Developing Countries
KW - Greater Antilles
KW - Antilles
KW - Caribbean
KW - Latin America
KW - behavior
KW - mental illness
KW - Porto Rico
KW - United States of America
KW - Conflict (UU495) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093184469&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/qk727j216n358245/fulltext.pdf
UR - email: MSafran@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Yersinia pestis over time in seeded bottled water samples by cultivation on heart infusion agar.
AU - Torosian, S. D.
AU - Began, P. M.
AU - Taylor, M. A.
AU - Margolin, A.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2009///
VL - 55
IS - 9
SP - 1125
EP - 1129
CY - Ottawa; Canada
PB - National Research Council of Canada
SN - 0008-4166
AD - Torosian, S. D.: Winchester Engineering and Analytical Center, Food and Drug Administration, Winchester, MA 01890, USA.
N1 - Accession Number: 20093333506. Publication Type: Journal Article. Language: English. Language of Summary: French. Number of References: 19 ref. Registry Number: 9002-18-0. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Human Nutrition
N2 - The viable persistence of Yersinia pestis seeded in bottled spring water was evaluated by performing 2 studies that involved inoculating a total of 21 different test strains into individual 500 mL reservoirs. Approximately 2×104 CFU/mL of Y. pestis was inoculated into each reservoir and held for sampling at 26°C±1°C. In study No. 2, 9 strains (Harbin, Nepal, UNH 1A, UNH 1B, ZE94, CO92, PB6, PB6 DP, and Pexu) could no longer be recovered using a plate count assay between 79 and 138 days post-seeding; other strains (K25 lcr, O19 Ca-6, and K25 pst) could no longer be recovered between 112 and 160 days post seeding. The data generated in this study demonstrate that certain strains of Y. pestis can remain viable in bottled water for extended periods of time.
KW - agar
KW - bottled water
KW - contaminants
KW - culture media
KW - infusion
KW - springs (water)
KW - Yersinia pestis
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093333506&site=ehost-live&scope=site
UR - http://cjm.nrc.ca
UR - email: info@unhmicrolab.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Sampling and analytical variability associated with the determination of total aflatoxins and ochratoxin A in powdered ginger sold as a dietary supplement in capsules.
AU - Trucksess, M. W.
AU - Whitaker, T. B.
AU - Weaver, C. M.
AU - Slate, A.
AU - Giesbrecht, F. G.
AU - Rader, J. I.
AU - Betz, J. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2009///
VL - 57
IS - 2
SP - 321
EP - 325
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Trucksess, M. W.: U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20093070907. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Medical & Veterinary Mycology; Plant Pathology; Aromatic & Medicinal Plants; Human Nutrition; Postharvest Research
N2 - The U.S. Food and Drug Administration is studying the need to monitor dietary supplements for mycotoxins such as total aflatoxins and ochratoxin A. An effective mycotoxin-monitoring program requires knowledge of the sampling and analytical variability associated with the determination of total aflatoxins (AF) and ochratoxin A (OTA) in dietary supplements. Three lots of ginger sold as a powder in capsule form and packaged in individual bottles were analyzed for both AF and OTA. The total variability associated with measuring AF and OTA in powdered ginger was partitioned into bottle-to-bottle, within bottle, and analytical variances. The variances were estimated using a nested design. For AF and OTA, the within-bottle variance associated with the 5 g laboratory sample size was the largest component of variability accounting for about 43% and 85% of the total variance, respectively; the analytical variance accounted for about 34% and 9% of the total variability, respectively; and the bottle-to-bottle variance accounted for about 23% and 7% of the total variance, respectively. When the total variance is converted into the coefficient of variation (CV or standard deviation relative to the mean concentration), the CV is lower for AF (16.9%) than OTA (24.7%).
KW - aflatoxins
KW - analysis of variance
KW - determination
KW - food contamination
KW - food supplements
KW - ginger
KW - mycotoxins
KW - ochratoxins
KW - sampling
KW - statistical analysis
KW - variance
KW - Zingiber
KW - Zingiber officinale
KW - Zingiberaceae
KW - Zingiberales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Zingiber
KW - food contaminants
KW - fungal toxins
KW - sampling techniques
KW - statistical methods
KW - variance analysis
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093070907&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue pesticide analysis of wines by dispersive solid-phase extraction and ultrahigh-performance liquid chromatography-tandem mass spectrometry.
AU - Zhang, K.
AU - Wong, J. W.
AU - Hayward, D. G.
AU - Sheladia, P.
AU - Krynitsky, A. J.
AU - Schenck, F. J.
AU - Webster, M. G.
AU - Ammann, J. A.
AU - Ebeler, S. E.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2009///
VL - 57
IS - 10
SP - 4019
EP - 4029
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Zhang, K.: Center for Food Safety and Applied Nutrition, HFS-706, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093179963. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Registry Number: 66215-27-8. Subject Subsets: Human Nutrition; Plant Pathology
N2 - A multiresidue pesticide method is described for the determination of 72 pesticides in wines. Pesticides were extracted using acetonitrile saturated with magnesium sulfate and sodium chloride, followed by solid-phase dispersive cleanup using primary-secondary amine and graphitized carbon black sorbents. Analysis is performed by ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-MS/MS). The limits of quantitation (LOQs) for most of the pesticides ranged from 0.3 to 3.3 µg/L with the exception of cyromazine, fenhexamid, and acibenzolar S-methyl (LOQ>10 µg/L), and quantitation was determined from calibration curves of standards containing 5.0-2500 µg/L with r2>0.99. Recovery studies were performed by fortifying wine samples with the pesticides to concentrations of 10, 100, and 1000 µg/L, resulting in recoveries of >80% for most of the pesticides. Lower (<70%) and higher (>120%) recoveries were most likely from complications of pesticide lability or volatility, matrix interference, or inefficient desorption from the solid-phase sorbents. The method was used to analyze 10 wines collected from a market basket survey, and 19 different pesticides, primarily fungicides, were present at concentrations ranging from <1.0 to 1000 µg/L.
KW - cyromazine
KW - extraction
KW - food contamination
KW - fungicides
KW - liquid chromatography
KW - mass spectrometry
KW - methodology
KW - pesticide residues
KW - pesticides
KW - wines
KW - food contaminants
KW - fungistats
KW - methods
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093179963&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: jon.wong@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determining the effect of calcium cations on acrylamide formation in cooked wheat products using a model system.
AU - Levine, R. A.
AU - Ryan, S. M.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2009///
VL - 57
IS - 15
SP - 6823
EP - 6829
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Levine, R. A.: Total Diet and Pesticide Research Center, U.S. Food and Drug Administration, 11510 West 80th Street, Lenexa, KS 66214, USA.
N1 - Accession Number: 20093260906. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 7440-70-2, 10137-74-3, 7647-14-5. Subject Subsets: Postharvest Research; Wheat, Barley & Triticale Abstracts; Human Nutrition
N2 - A model system was used to cook wheat flour and water dough pieces in sealed pressure tubes under controlled pH conditions and with various additives in the recipe water to determine acrylamide (AA) formation and elimination. The potential effectiveness of calcium as CaCl2 or CaCO3 salts to reduce the formation of AA in wheat based food products was assessed. Since the divalent Ca2+ was capable of inducing significant pH reduction in the dough, and pH lowering is known to reduce AA formation, it was necessary in some cases to adjust the pH before cooking or use a pH matched control. For comparison, the effect of NaCl on AA formation was also determined. It was found that AA reduction up to 36% was obtained by adding CaCl2 to the recipe water at a 0.04 M concentration, compared to 23% for 0.04 M NaCl, and there was no reduction when CaCO3 was added to simulate a calcium enriched flour.
KW - acrylamides
KW - calcium
KW - calcium chlorate
KW - doughs
KW - pH
KW - sodium chloride
KW - wheat
KW - wheat flour
KW - Triticum
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - hydrogen ion concentration
KW - NaCl
KW - pastry
KW - potential of hydrogen
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093260906&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: robert.levine@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chemical food safety issues in the United States: past, present, and future.
AU - Jackson, L. S.
A2 - Armstrong, R. N.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2009///
VL - 57
IS - 18
SP - 8161
EP - 8170
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Jackson, L. S.: National Center for Food Safety and Technology (NCFST), U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois 60501, USA.
N1 - Accession Number: 20093314155. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 109 ref. Registry Number: 108-78-1. Subject Subsets: Human Nutrition; Animal Nutrition
N2 - Considerable advances have been made over the past century in the understanding of the chemical hazards in food and ways for assessing and managing these risks. At the turn of the 20th century, many Americans were exposed to foods adulterated with toxic compounds. In the 1920s the increasing use of insecticides led to concerns of chronic ingestion of heavy metals such as lead and arsenic from residues remaining on crops. By the 1930s, a variety of agrochemicals were commonly used, and food additives were becoming common in processed foods. During the 1940s and 1950s advances were made in toxicology, and more systematic approaches were adopted for evaluating the safety of chemical contaminants in food. Modern gas chromatography and liquid chromatography, both invented in the 1950s and 1960s, were responsible for progress in detecting, quantifying, and assessing the risk of food contaminants and adulterants. In recent decades, chemical food safety issues that have been the center of media attention include the presence of natural toxins, processing-produced toxins (e.g., acrylamide, heterocyclic aromatic amines, and furan), food allergens, heavy metals (e.g., lead, arsenic, mercury, cadmium), industrial chemicals (e.g., benzene, perchlorate), contaminants from packaging materials, and unconventional contaminants (melamine) in food and feed. Due to the global nature of the food supply and advances in analytical capabilities, chemical contaminants will continue to be an area of concern for regulatory agencies, the food industry, and consumers in the future.
KW - adulteration
KW - allergens
KW - chemicals
KW - feeds
KW - food contamination
KW - food safety
KW - gas chromatography
KW - heavy metals
KW - liquid chromatography
KW - melamine
KW - packaging materials
KW - toxins
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - feeding stuffs
KW - food contaminants
KW - United States of America
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093314155&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: Lauren.Jackson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Acrylamide formed at physiological temperature as a result of asparagine oxidation.
AU - Tareke, E.
AU - Heinze, T. M.
AU - Gamboa Costa, G. da
AU - Ali, S.
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
Y1 - 2009///
VL - 57
IS - 20
SP - 9730
EP - 9733
CY - Washington; USA
PB - American Chemical Society
SN - 0021-8561
AD - Tareke, E.: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
N1 - Accession Number: 20093337746. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Registry Number: 70-47-3.
N2 - Acrylamide is a probable human carcinogen that is neurotoxic to both humans and animals. It is known to be formed during cooking of foods at temperatures higher than 120°C. The present study demonstrates that acrylamide can also be formed at physiological conditions (37°C, pH 7.4) when asparagine is incubated in the presence of hydrogen peroxide (H2O2). The formation of acrylamide under these conditions is dependent on the incubation time and the concentration of H2O2. Thus, the results raise the question of the possible endogenous formation of acrylamide in pathological conditions that are associated with long-term oxidative stress. Further studies are therefore warranted to clarify the possible endogenous formation of acrylamide and its significance in chronic conditions that are known to be associated with oxidative stress.
KW - acrylamides
KW - asparagine
KW - carcinogens
KW - cooking
KW - formation
KW - temperature
KW - Food Processing (General) (QQ100)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093337746&site=ehost-live&scope=site
UR - http://pubs.acs.org/journals/jafcau/index.html
UR - email: edunatar@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assignment of the group A rotavirus NSP4 gene into genotypes using a hemi-nested multiplex PCR assay: a rapid and reproducible assay for strain surveillance studies.
AU - Bányai, K.
AU - Bogdán, Á.
AU - Szücs, G.
AU - Arista, S.
AU - Grazia, S. de
AU - Kang, G.
AU - Banerjee, I.
AU - Iturriza-Gómara, M.
AU - Buonavoglia, C.
AU - Martella, V.
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
Y1 - 2009///
VL - 58
IS - 3
SP - 303
EP - 311
CY - Reading; UK
PB - Society for General Microbiology
SN - 0022-2615
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20093088877. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Subject Subsets: Pig Science; Public Health; Veterinary Science; Veterinary Science
N2 - The rotavirus non-structural protein NSP4 has been implicated in a number of biological functions during the rotavirus cellular cycle and pathogenesis, and has been addressed as a target for vaccine development. The NSP4 gene has been classified into six genotypes (A-F). A semi-nested triplex PCR was developed for genotyping the major human NSP4 genotypes (A-C), which are common in human rotavirus strains but are also shared among most mammalian rotavirus strains. A total of 192 previously characterized human strains representing numerous G and P type specificities (such as G1P[8], G1P[4], G2P[4], G3P[3], G3P[8], G3P[9], G4P[6], G4P[8], G6P[4], G6P[9], G6P[14], G8P[10], G8P[14], G9P[8], G9P[11], G10P[11], G12P[6] and G12P[8]) were tested for NSP4 specificity by the collaborating laboratories. An additional 35 animal strains, including the reference laboratory strains SA11 (simian, G3P[2]), NCDV (bovine, G6P[1]), K9 and CU-1 (canine, G3P[3]), together with 31 field isolates (canine, G3P[3]; feline, G3P[9]; porcine, G2P[23], G3P[6], G4P[6], G5P[6], G5P[7], G5P[26], G5P[27], G9P[6] and G9P[7]) were also successfully NSP4-typed. Four human G3P[9] strains and one feline G3P[9] strain were found to possess an NSP4 A genotype, instead of NSP4 C, suggesting a reassortment event between heterologous strains. Routine NSP4 genotyping may help to determine the genomic constellation of rotaviruses of man and livestock, and identify interspecies transmission of heterologous strains.
KW - analytical methods
KW - genes
KW - genotypes
KW - polymerase chain reaction
KW - strains
KW - viral proteins
KW - cats
KW - man
KW - Rotavirus A
KW - Felis
KW - Felidae
KW - Fissipeda
KW - carnivores
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - Rotavirus
KW - Reoviridae
KW - dsRNA Viruses
KW - RNA Viruses
KW - viruses
KW - analytical techniques
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093088877&site=ehost-live&scope=site
UR - http://jmm.sgmjournals.org/
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Adult blood lead epidemiology and surveillance - United States, 2005-2007.
AU - Alarcon, W. A.
AU - Roscoe, R. J.
AU - Calvert, G. M.
AU - Graydon, J. R.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2009///
VL - 58
IS - 14
SP - 365
EP - 369
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 1057-5987
AD - Alarcon, W. A.: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20093130306. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 7439-92-1. Subject Subsets: Public Health
N2 - This report summarizes results of the Adult Blood Lead Epidemiology and Surveillance in USA for the period 2005-2007. An overall decline was observed in the national rates of elevated blood lead levels (BLLs) among state residents plus non-residents from 14.0 in 1994 to 7.8 in 2007. The national rate of state resident adults with BLLs ≥25 µg/dl was 7.2 per 100 000 employed adults in 2005, and 7.4 in 2006 and 2007. Industry subsectors with the highest numbers of lead-exposed workers were manufacturing of storage batteries, mining of lead and zinc ores, and painting and paper hanging. The most common non-occupational exposures were shooting firearms; remodelling, renovating, or painting; retained bullets (gunshot wounds); and eating food contaminated with lead. These findings indicate a need for increased preventive interventions to promote healthier workplaces and help move toward the Healthy People 2010 objective.
KW - adults
KW - blood
KW - epidemiology
KW - exposure
KW - industrial workers
KW - lead
KW - men
KW - miners
KW - occupational hazards
KW - occupational health
KW - painters
KW - toxic substances
KW - women
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - poisons
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093130306&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Work-related fatalities associated with tree care operations - United States, 1992-2007.
AU - Castillo, D. N.
AU - Menéndez, C. K. C.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2009///
VL - 58
IS - 15
SP - 389
EP - 393
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Castillo, D. N.: Div of Safety Research, National Institute for Occupational Safety and Health, CDC, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20093170820. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Forest Products; Public Health; Forestry
N2 - The characteristics of fatal occupational injuries (CFOI) and a case series of fatality investigations conducted by the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Healthy Fatality Assessment and Control Evaluation programme were summarized. During 1992-2007, a total of 1285 workers died while performing tree care and maintenance; 44% were trimming or pruning a tree when fatally injured. The most common causes of death were being struck by or against an object (42% of deaths), most commonly a tree or branch; falls to a lower level (34%); and electrocutions (14%). Most of the decedents (57%) worked for small establishments with 10 or fewer employees. It is suggested that employers, trade and worker associations, and policymakers should take additional steps to improve the safety of workers involved in tree care, such as providing formal training to workers and ensuring that personal protective equipment (e.g. fall protection equipment) is used properly.
KW - electrocution
KW - epidemiology
KW - forestry workers
KW - human diseases
KW - mortality
KW - occupational hazards
KW - occupational health
KW - protective clothing
KW - safety at work
KW - safety devices
KW - trauma
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - death rate
KW - occupational safety
KW - traumas
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
KW - Forestry, Forest Products and Agroforestry (General) (KK000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093170820&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/mmwr_wk.html
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pseudo-outbreak of antimony toxicity in firefighters - Florida, 2009.
AU - Kawamoto, M.
AU - Durgam, S.
AU - Eisenberg, J.
AU - Caldwell, K.
AU - Perio, M. de
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2009///
VL - 58
IS - 46
SP - 1300
EP - 1302
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Kawamoto, M.: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC, 1600 Clifton Rd., Atlanta, GA 30333, USA.
N1 - Accession Number: 20093346225. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 7440-36-0. Subject Subsets: Public Health
N2 - In October 2008, the Centers for Disease Control and Prevention (CDC) received a report from the fire chief of a fire department in Florida (fire department A) regarding an outbreak of antimony toxicity among 30 firefighters who had elevated antimony levels detected in hair samples. This report summarizes the ensuing health hazard evaluation conducted by CDC to determine the source of antimony exposure. In February 2009, CDC administered questionnaires to and collected urine samples from two groups of firefighters: 20 firefighters from fire department A who did not wear pants made from antimony-containing fabric, and 42 firefighters from fire department B (also located in Florida) who did. All 20 firefighters from fire department A and 41 (98%) from fire department B had urine antimony concentrations below or within the laboratory reference range. CDC concluded that wearing pants made from antimony-containing fabric was not associated with elevated levels of urinary antimony. Only validated methods (e.g., urine testing) should be used for the determination of antimony toxicity. Accurate and timely risk communication during suspected workplace exposures should underscore the importance of using validated tests, thereby refuting an unproven hypothesis, allaying unsubstantiated concerns, and enhancing public trust.
KW - antimony
KW - exposure
KW - fabrics
KW - fire fighters
KW - hair
KW - human diseases
KW - occupational hazards
KW - occupational health
KW - protective clothing
KW - toxic substances
KW - toxicity
KW - urine
KW - Florida
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gulf States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - South Atlantic States of USA
KW - Southeastern States of USA
KW - firemen
KW - poisons
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093346225&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/PDF/wk/mm5846.pdf
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Coal workers' pneumoconiosis-related years of potential life lost before age 65 years - United States, 1968-2006.
AU - Mazurek, J. M.
AU - Laney, A. S.
AU - Wood, J. M.
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
Y1 - 2009///
VL - 58
IS - 50
SP - 1412
EP - 1416
CY - Atlanta; USA
PB - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC)
SN - 0149-2195
AD - Mazurek, J. M.: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC, Atlanta, Georgia, USA.
N1 - Accession Number: 20103018304. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - During 1968-2006, coal workers' pneumoconiosis (CWP) was identified as the underlying cause of death for 28 912 decedents aged ≥25 years. Of these, 3983 (13.8%) were aged 25-64 years, including four (0.1%) aged 25-34 years, 40 (1.0%) aged 35-44 years, 494 (12.4%) aged 45-54 years, and 3445 (86.5%) aged 55-64 years, accounting for 22 625 years of potential life lost (YPLL; mean per decedent, 5.7). Among CWP decedents aged 25-64 years, 3954 (99.3%) were male and 3891 (97.7%) were white, accounting for 22 283 (98.5%) and 21 893 (96.8%) YPLL, respectively. The mean YPLL per decedent was greatest for the few females (11.8) and blacks (8.1). Overall, CWP deaths among US residents aged ≥25 years declined by 73%, from an average of 1106.2 per year during 1968-1972 to 300.0 per year during 2002-06 (regression trend, p<0.001). Age-adjusted death rates among residents aged 25-64 years declined by 96%, from 1.78 per million in 1968 to 0.07 in 2006. Age-adjusted death rates among residents aged ≥65 years also declined by 84%, from 6.24 per million in 1968 to 1.02 in 2006. CWP-attributable YPLL varied annually, from a high of 1768 (mean per decedent: 6.0) in 1970 to a low of 66 (mean per decedent: 5.5) in 2001. YPLL increased from 66 in 2001 to 198 in 2005, and then declined to 169 in 2006. Overall, YPLL decreased by 91%, from an average of 1484.2 per year during 1968-1972 to 153.8 per year during 2002-06 (regression trend, p<0.001). The mean YPLL per decedent increased 47%, from 5.3 per decedent during 1968-1972 to 7.8 during 2002-06 (regression trend, p<0.001). During 1968-2006, CWP deaths in Pennsylvania (n=2845; 15 420 YPLL), West Virginia (n=281; 1640 YPLL), Virginia (n=191; 1314 YPLL), Kentucky (n=209; 1273 YPLL), and Ohio (n=91; 543 YPLL) accounted for 90.8% of all decedents aged 25-64 years with CWP as the underlying cause of death and 89.2% of the total YPLL attributed to CWP.
KW - blacks
KW - coal workers
KW - elderly
KW - epidemiology
KW - human diseases
KW - men
KW - mortality
KW - occupational hazards
KW - occupational health
KW - pneumoconioses
KW - trends
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - aged
KW - death rate
KW - elderly people
KW - older adults
KW - pneumoconiosis
KW - senior citizens
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103018304&site=ehost-live&scope=site
UR - http://www.cdc.gov/mmwr/PDF/wk/mm5850.pdf
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - HLA type and immune response to Borrelia burgdorferi outer surface protein A in people in whom arthritis developed after Lyme disease vaccination.
AU - Ball, R.
AU - Shadomy, S. V.
AU - Meyer, A.
AU - Huber, B. T.
AU - Leffell, M. S.
AU - Zachary, A.
AU - Belotto, M.
AU - Hilton, E.
AU - Bryant-Genevier, M.
AU - Schriefer, M. E.
AU - Miller, F. W.
AU - Braun, M. M.
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
Y1 - 2009///
VL - 60
IS - 4
SP - 1179
EP - 1186
CY - Atlanta; USA
PB - American College of Rheumatology Educational Foundation
SN - 0004-3591
AD - Ball, R.: Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA.
N1 - Accession Number: 20093118990. Publication Type: Journal Article. Language: English. Registry Number: 308067-58-5, 50-89-5. Subject Subsets: Medical & Veterinary Entomology; Public Health
N2 - Objective: To investigate whether people with treatment-resistant Lyme arthritis-associated HLA alleles might develop arthritis as a result of an autoimmune reaction triggered by Borrelia burgdorferi outer surface protein A (OspA), the Lyme disease vaccine antigen. Methods: Patients in whom inflammatory arthritis had developed after Lyme disease vaccine (cases) were compared with 3 control groups: (1) inflammatory arthritis but not Lyme disease vaccine (arthritis controls); (2) Lyme disease vaccine but not inflammatory arthritis (vaccine controls); and (3) neither Lyme disease vaccine nor inflammatory arthritis (normal controls). HLA-DRB1 allele typing, Western blotting for Lyme antigen, and T cell reactivity testing were performed. Results: 27 cases were matched with 162 controls (54 in each control group). The odds ratios (ORs) for the presence of 1-2 treatment-resistant Lyme arthritis alleles were 0.8 (95% confidence interval (95% CI): 0.3-2.1), 1.6 (95% CI: 0.5-4.4) and 1.75 (95% CI: 0.6-5.3) in cases versus arthritis controls, vaccine controls and normal controls, respectively. There were no significant differences in the frequency of DRB1 alleles. T cell response to OspA was similar between cases and vaccine controls, as measured using the stimulation index (OR, 1.6; 95% CI: 0.5-5.1) or change in uptake of tritiated thymidine (counts per minute; OR, 0.7; 95% CI: 0.2-2.3), but cases were less likely to have IgG antibodies to OspA (OR, 0.3; 95% CI: 0.1-0.8). Cases were sampled closer to the time of vaccination (median, 3.59 vs. 5.48 years), and fewer cases had received 3 doses of vaccine (37 vs. 93%). Conclusion: Treatment-resistant Lyme arthritis alleles are not more common in people who develop arthritis after Lyme disease vaccination, and immune responses to OspA are not significantly more common in arthritis cases. These results suggest that Lyme disease vaccine is not a major factor in the development of arthritis in these cases.
KW - alleles
KW - arthritis
KW - autoimmunity
KW - bacterial diseases
KW - genes
KW - histocompatibility antigens
KW - human diseases
KW - human leukocyte antigens
KW - IgG
KW - immune response
KW - immunization
KW - Lyme disease
KW - protective antigens
KW - surface proteins
KW - T lymphocytes
KW - thymidine
KW - vaccination
KW - vaccines
KW - Borrelia burgdorferi
KW - man
KW - Borrelia
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - lyme borreliosis
KW - membrane proteins
KW - T cells
KW - Host Resistance and Immunity (HH600)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093118990&site=ehost-live&scope=site
UR - http://www3.interscience.wiley.com/journal/122290638/abstract
UR - email: Robert.Ball@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Qualified health claims for calcium and colorectal, breast, and prostate cancers: the U.S. Food and Drug Administration's evidence-based review.
AU - Kavanaugh, C. J.
AU - Trumbo, P. R.
AU - Ellwood, K. C.
JO - Nutrition and Cancer
JF - Nutrition and Cancer
Y1 - 2009///
VL - 61
IS - 2
SP - 157
EP - 164
CY - Philadelphia; USA
PB - Routledge
SN - 0163-5581
AD - Kavanaugh, C. J.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20093122713. Publication Type: Journal Article. Language: English. Number of References: 53 ref. Registry Number: 7440-70-2. Subject Subsets: Human Nutrition; Public Health
N2 - In 2003, the United States Food and Drug Administration (FDA) received a health claim petition for calcium supplements and reduced risk of colorectal, breast, and prostate cancers. Health claims characterize the relationship between a substance (food or food component) and disease (e.g., cancer or cardiovascular disease) or health-related condition (e.g., hypertension) and require premarket approval for the labeling of conventional foods and dietary supplements by the FDA. This review describes how the FDA used the evidence-based review system to evaluate the scientific evidence for these proposed health claims. FDA found no credible evidence to support health claims for calcium and a reduced risk of breast and prostate cancers. The agency did find limited evidence for the relationship between calcium intake and colorectal cancer risk.
KW - breast
KW - breast cancer
KW - calcium
KW - colon
KW - colorectal cancer
KW - human diseases
KW - mineral supplements
KW - neoplasms
KW - prostate
KW - prostate cancer
KW - reviews
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - breasts
KW - cancers
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093122713&site=ehost-live&scope=site
UR - http://www.informaworld.com/smpp/content~content=a908886084~db=all~order=page
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Characterization of Salmonella enterica isolates from infants and toddlers in Wuhan, China.
AU - Cui ShengHui
AU - Li JingYun
AU - Sun ZiYong
AU - Hu ChangQin
AU - Jin ShaoHong
AU - Li FengQin
AU - Guo YunChang
AU - Ran Lu
AU - Ma Yue
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2009///
VL - 63
IS - 1
SP - 87
EP - 94
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Cui ShengHui: The National Center for Surveillance of Antimicrobial Resistance, The State Food and Drug Administration, Beijing, China.
N1 - Accession Number: 20093034881. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 9001-74-5, 73384-59-5, 74578-69-1, 85721-33-1. Subject Subsets: Tropical Diseases
N2 - Background: Extended-spectrum cephalosporins and fluoroquinolones are important antimicrobials for treating invasive salmonellosis, and emerging resistance to these antimicrobials is of paramount concern. This study reports on the antimicrobial susceptibility and molecular characterization of Salmonella enterica isolates recovered in 2006 from 0- to 3-year-old outpatients in China. Methods: The isolates were subjected to serotyping, antimicrobial susceptibility testing, screening for β-lactamase genes, mutations in the quinolone resistance determining regions (QRDRs), qnr alleles and aac-(6′)-Ib-cr by PCR followed by DNA sequence analysis. All Salmonella Typhimurium isolates and 43 selected non-Typhimurium isolates were further characterized by PFGE to determine the genetic relatedness. Results: From 3746 paediatric outpatient stool samples, 221 (5.9%) S. enterica isolates of 29 distinct serotypes were recovered. The antimicrobial resistance profiles differed among serotypes. Ciprofloxacin-resistant isolates were concentrated in serotype Typhimurium that were resistant to at least four additional non-quinolone antimicrobials. Nineteen out of 22 ciprofloxacin-resistant Salmonella Typhimurium isolates were grouped into one PFGE cluster. Plasmid-mediated quinolone resistance determinant aac-(6′)-Ib-cr was detected in 18 S. enterica isolates and 4 isolates also carried qnr alleles. Plasmid-mediated blaCTX-M-14-like genes were found in seven ceftriaxone-resistant isolates, and two isolates also exhibited reduced susceptibility to ciprofloxacin. Conclusions: Based on these results, fluoroquinolones should not be used to treat the invasive Salmonella Typhimurium infections in this local community. The monitoring programme should stay vigilant for ceftriaxone-resistant S. enterica isolates with reduced fluoroquinolone susceptibility.
KW - alleles
KW - antibacterial agents
KW - beta-lactamase
KW - ceftriaxone
KW - ciprofloxacin
KW - drug resistance
KW - genes
KW - human diseases
KW - infants
KW - mutations
KW - quinolones
KW - serotypes
KW - Central Southern China
KW - China
KW - man
KW - Salmonella enterica
KW - Salmonella Typhimurium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - China
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - bacterium
KW - penicillinase
KW - People's Republic of China
KW - Pesticide and Drug Resistance (HH410)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093034881&site=ehost-live&scope=site
UR - http://jac.oxfordjournals.org/cgi/content/full/63/1/87
UR - email: nicpbp@263.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China.
AU - Cui ShengHui
AU - Li JingYun
AU - Hu ChangQin
AU - Jin ShaoHong
AU - Li FengQin
AU - Guo YunChang
AU - Ran Lu
AU - Ma Yue
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Y1 - 2009///
VL - 64
IS - 4
SP - 680
EP - 683
CY - Oxford; UK
PB - Oxford University Press
SN - 0305-7453
AD - Cui ShengHui: The State Food and Drug Administration, Beijing, China.
N1 - Accession Number: 20093305486. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Registry Number: 33564-30-6, 35607-66-0, 56-75-7, 85721-33-1, 18323-44-9, 114-07-8, 1403-66-3, 1405-41-0, 61-32-5. Subject Subsets: Pig Science; Veterinary Science; Veterinary Science; Tropical Diseases
N2 - Objectives: The objectives of this study were to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in livestock and related workers in four Chinese provinces and the characteristics of these isolates. Methods: Nasal swabs were collected from animals and farm workers in four Chinese provinces. MRSA isolates were recovered and characterized by PFGE, Panton-Valentine leucocidin PCR, staphylococcal chromosomal cassette (SCC) mec typing, spa typing, multilocus sequence typing, antimicrobial susceptibility testing and testing for inducible clindamycin resistance. Results: A total of 60 MRSA isolates were recovered from swine and swine workers. Two predominant multidrug resistance profiles were identified: ciprofloxacin/clindamycin/erythromycin/cefoxitin/gentamicin/tetracycline/chloramphenicol and ciprofloxacin/clindamycin/erythromycin/cefoxitin/gentamicin/tetracycline. All isolates were determined to be spa type t899, contained the group III SCCmec element and were Panton-Valentine leucocidin negative. Multilocus sequence type ST9 (n=46) was identified as the dominant sequence type. One dominant PFGE cluster and a dominant strain type were identified. Conclusions: MRSA from Chinese pigs and farm workers (ST9) differed from the European pig-associated clone (ST398) with regard to clonal type, SCCmec content and resistance profile.
KW - antibacterial agents
KW - carrier state
KW - cefoxitin
KW - chloramphenicol
KW - ciprofloxacin
KW - clindamycin
KW - drug resistance
KW - erythromycin
KW - genes
KW - gentamicin
KW - loci
KW - methicillin
KW - multiple drug resistance
KW - nose
KW - nucleotide sequences
KW - pig farmers
KW - resistance mechanisms
KW - strains
KW - China
KW - pigs
KW - Staphylococcus aureus
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - bacterium
KW - DNA sequences
KW - hogs
KW - People's Republic of China
KW - swine
KW - tetraclycline
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Pesticide and Drug Resistance (HH410)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093305486&site=ehost-live&scope=site
UR - http://jac.oxfordjournals.org/cgi/content/full/64/4/680
UR - email: nicpbp@263.net
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Preliminary evaluation of a procedure for improved detection of Shiga toxin-producing Escherichia coli in fecal specimens.
AU - Hu, J. X.
AU - Green, D.
AU - Swoveland, J.
AU - Grant, M.
AU - Boyle, D. S.
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
Y1 - 2009///
VL - 65
IS - 1
SP - 21
EP - 26
CY - New York; USA
PB - Elsevier
SN - 0732-8893
AD - Hu, J. X.: U.S. Food and Drug Administration, Bothell, WA 98021, USA.
N1 - Accession Number: 20093247938. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Culture confirmation of Shiga toxin-producing Escherichia coli (STEC) is very important for epidemiologic analysis. However, isolation of non-O157 STEC on conventional selective media such as sorbitol-MacConkey agar (SMAC) can be difficult because of heavy growth of competing bacteria and its phenotypical similarity to commensal nonpathogenic E. coli. An acid enrichment procedure was introduced in this study to facilitate detection of STEC from patients who were symptomatic. Forty-seven clinical fecal broths, which tested positive for Shiga toxin by commercial immunoassay, were processed for the isolation of STEC by both conventional and the acid enrichment methods. The acid enrichment method and conventional culture recovered STEC from 91% (43/47) and 70% (33/47) of the fecal broths, respectively. Neither method retrieved STEC in 3 specimens. Thirty-six STEC were successfully serogrouped, which included O26 (n=11), O157 (n=9), O103 (n=7), O121 (n=3), O111 (n=2 each), O28AC, O146, O76, and O undetermined (n=1 each). The analysis of STEC isolates by real-time PCR indicated that all 9 E. coli O157 contained stx2 gene alone or in combination with stx1. Non-O157 STEC more frequently contained stx1 only, and about one-third possessed stx2. The novel acid enrichment protocol greatly reduced the growth of competitor colonies on RTN and TCSMAC. The study demonstrated that incorporation of an acid enrichment procedure in clinical testing improved the isolation of STEC in fecal specimens.
KW - bacterial diseases
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - faecal examination
KW - faeces
KW - human diseases
KW - methodology
KW - shiga toxin-producing Escherichia coli
KW - toxins
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - E. coli
KW - fecal examination
KW - feces
KW - methods
KW - STEC
KW - VTEC
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093247938&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T60-4X01J1H-4&_user=10&_coverDate=09%2F30%2F2009&_rdoc=4&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235016%232009%23999349998%231414061%23FLA%23display%23Volume)&_cdi=5016&_sort=d&_docanchor=&_ct=15&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=8b93b4e49450c0f362e38f24dcdfcb1c
UR - email: jinxin.hu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Asbestosis mortality in the USA: facts and predictions.
AU - Antao, V. C. dos S.
AU - Pinheiro, G. A.
AU - Wassell, J. T.
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
Y1 - 2009///
VL - 66
IS - 5
SP - 335
EP - 338
CY - London; UK
PB - BMJ Publishing Group
SN - 1351-0711
AD - Antao, V. C. dos S.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
N1 - Accession Number: 20093134108. Publication Type: Journal Article. Language: English. Registry Number: 1332-21-4. Subject Subsets: Public Health
N2 - Mortality trends in the USA show that deaths from asbestosis are increasing, while deaths related to other pneumoconiosis are declining. An epidemiological time series study was carried out to analyse the association between asbestos consumption and asbestosis mortality trends. Modern computer-intensive local regression method was used to evaluate the relationship between asbestos consumption per capita (1900-2006) as the predictor variable and number of deaths from asbestosis (1968-2004). The predictor variable was progressively lagged by annual increments from 30 to 60 years and the goodness of fit assessed for each lag period. The model having the smallest Akaike's Information Criteria was used to derive extrapolated estimates of future mortality based on more recent asbestos consumption data. Asbestos consumption per capita reached a peak in 1951 and gradually declined until 1973, when it started to drop rapidly. In 2006, it was 0.0075 kg/person/year. There were 25 564 deaths from asbestosis over the period 1968-2004. The best-fitting model (adjusted coefficient of determination (R2)=99.7%) for 1968-2004 deaths from asbestosis used asbestos consumption per capita 48 years prior (1920-1956) and the log value of asbestos consumption per capita 43 years prior (1925-1961). This model predicts a total of 29 667 deaths (95% CI 19 629 to 39 705) to occur during 2005-2027 (an average of 1290 deaths per year). This study demonstrates a clear association between asbestos consumption and deaths from asbestosis and indicates that asbestosis deaths are not expected to decrease sharply in the next 10-15 years.
KW - asbestos
KW - asbestosis
KW - epidemiology
KW - exposure
KW - human diseases
KW - mortality
KW - pneumoconioses
KW - respiratory diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - death rate
KW - lung diseases
KW - pneumoconiosis
KW - United States of America
KW - Pollution and Degradation (PP600)
KW - Demography (UU200)
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093134108&site=ehost-live&scope=site
UR - http://oem.bmj.com/cgi/content/abstract/66/5/335
UR - email: VAntao@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Is perceived racial privilege associated with health? Findings from the Behavioral Risk Factor Surveillance System.
AU - Fujishiro, K.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2009///
VL - 68
IS - 5
SP - 840
EP - 844
CY - Oxford; UK
PB - Elsevier
SN - 0277-9536
AD - Fujishiro, K.: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation, and Field Studies, 4676 Columbia Parkway (R-17), Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093170953. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - While racial discrimination has gained increasing attention in public health research, little is known about perceived racial privilege and health. Using the Behavioral Risk Factor Surveillance System (BRFSS) data, this study explored the relationship of both perceived racial discrimination and privilege with well-being in the USA. Data were extracted from the BRFSS 2004 data set, in which 22,412 respondents in seven states and one major city provided data on perceived racial discrimination and privilege at work. Logistic regression analysis was conducted to examine the relationships of differential racial treatment to self-rated general health status and the number of physically and mentally unhealthy days. Racially stratified analyses found that perceived racial privilege was significantly associated with more days of poor physical and mental health. This relationship was consistent for Whites, but for racial minorities it appeared on only some outcome measures. Reports of being treated worse than other races in the workplace were associated with poor health for all racial groups, as had been reported in previous studies on racial discrimination. Because racial discrimination and racial privilege are both products of racism, this study's findings suggest that racism may harm all involved. Impacts of perceived racial privilege deserve more attention in the literature on racism and health.
KW - epidemiology
KW - ethnicity
KW - health care
KW - public health
KW - racial discrimination
KW - risk factors
KW - surveillance
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - ethnic differences
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093170953&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/02779536
UR - email: kfujishiro@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Inactivation of Yersinia pseudotuberculosis 197 and Francisella tularensis LVS in beverages by high pressure processing.
AU - Schlesser, J. E.
AU - Parisi, B.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 1
SP - 165
EP - 168
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Schlesser, J. E.: Food and Drug Administration, National Center for Food Safety and Technology, Moffett Campus, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20103047604. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Medical & Veterinary Entomology; Dairy Science
N2 - In 2003, the U.S. Department of Health and Human Services announced a new research program to develop technologies and strategies to prevent and minimize potential food safety and security threats. The threat of terrorist attacks against the nation's food supplies has created the need to study microorganisms not typically associated with foodborne illness. High-pressure processing has been proposed as a treatment to reduce Yersinia pestis and Francisella tularensis LVS levels in beverages. The objectives of this work were to determine the pressure resistance of Y. pseudotuberculosis 197 (surrogate for Y. pestis) and F. tularensis LVS (vaccine strain). For each bacterium, samples of ultrahigh-temperature pasteurized skim milk and pasteurized reduced-acid orange juice (pH ca. 4.2) were inoculated at a minimum level of 5 log CFU/ml. Ten-milliliter samples of the inoculated product were vacuum sealed in polyester pouches and subjected to pressures of 300 and 500 MPa for holding times ranging from 30 s to 6 min. One set of trials was performed at an initial temperature of 10°C and another at 25°C. Processed samples were immediately plated and enumerated. A pressure treatment of 300 MPa at 25°C for less than 6 min was not sufficient to achieve a 5-log reduction of Y. pseudotuberculosis 197 or F. tularensis LVS in milk. However, a pressure treatment of 500 MPa was effective at hold times as low as 30 s. Overall, F. tularensis LVS demonstrated less pressure resistance than Y. pseudotuberculosis 197. Based on these findings, a high-pressure process designed to inactivate 5 log CFU of Y. pseudotuberculosis 197 per ml and F. tularensis LVS in orange juice or milk should be set at or above 500 MPa with a hold time of 2 min or greater.
KW - decontamination
KW - food contamination
KW - food safety
KW - milk
KW - orange juice
KW - pressure treatment
KW - skim milk
KW - tularaemia
KW - UHT milk
KW - UHT treatment
KW - USA
KW - Francisella tularensis
KW - Yersinia pseudotuberculosis
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - tularemia
KW - UHT
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Crop Produce (QQ050)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103047604&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: joseph.schlesser@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Microbiological quality of ready-to-eat food served in schools in Wales, United Kingdom.
AU - Meldrum, R. J.
AU - Mannion, P. T.
AU - Garside, J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 1
SP - 197
EP - 201
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Meldrum, R. J.: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK.
N1 - Accession Number: 20103047612. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - A survey of the general microbiological quality of ready-to-eat food served in schools was undertaken across Wales, United Kingdom. Of the 2,351 samples taken, four were identified as containing unsatisfactory counts of Escherichia coli, four contained unsatisfactory counts of Staphylococcus aureus, and one contained an unacceptable count of Bacillus cereus when compared with guidelines for the microbiological quality of ready-to-eat food published by the United Kingdom Public Health Laboratory Service in 2000. No samples contained detectable levels of Salmonella, Listeria species, or Clostridium perfringens. When compared with data on the general microbiological quality of food available in Wales, the food sampled from schools was of relatively better microbiological quality.
KW - fast food restaurants
KW - food contamination
KW - human diseases
KW - listeriosis
KW - salmonellosis
KW - school meals
KW - schools
KW - UK
KW - Wales
KW - Bacillus cereus
KW - Clostridium perfringens
KW - Escherichia coli
KW - Listeria
KW - man
KW - Salmonella
KW - Staphylococcus aureus
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Clostridium
KW - Clostridiaceae
KW - Clostridiales
KW - Clostridia
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Listeriaceae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - bacterium
KW - Britain
KW - E. coli
KW - food contaminants
KW - listerellosis
KW - Salmonella infections
KW - school buildings
KW - United Kingdom
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Food Service (QQ700) (New June 2002)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103047612&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: richard.meldrum@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Increased UVA exposures and decreased cutaneous vitamin D3 levels may be responsible for the increasing incidence of melanoma.
AU - Godar, D. E.
AU - Landry, R. J.
AU - Lucas, A. D.
JO - Medical Hypotheses
JF - Medical Hypotheses
Y1 - 2009///
VL - 72
IS - 4
SP - 434
EP - 443
CY - Oxford; UK
PB - Elsevier
SN - 0306-9877
AD - Godar, D. E.: US Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Avenue (HFZ-120), Silver Spring, MD 20993-0002, USA.
N1 - Accession Number: 20093089264. Publication Type: Journal Article. Language: English. Number of References: 108 ref. Registry Number: 67-97-0. Subject Subsets: Public Health; Human Nutrition
N2 - Cutaneous malignant melanoma (CMM) has been increasing at a steady exponential rate in fair-skinned, indoor workers since before 1940. A paradox exists between indoor and outdoor workers because indoor workers get three to nine times less solar UV (290-400 nm) exposure than outdoor workers get, yet only indoor workers have an increasing incidence of CMM. Thus, another "factor(s)" is/are involved that increases the CMM risk for indoor workers. We hypothesize that one factor involves indoor exposures to UVA (321-400 nm) passing through windows, which can cause mutations and can break down vitamin D3 formed after outdoor UVB (290-320 nm) exposure, and the other factor involves low levels of cutaneous vitamin D3. After vitamin D3 forms, melanoma cells can convert it to the hormone, 1,25-dihydroxyvitamin D3, or calcitriol, which causes growth inhibition and apoptotic cell death in vitro and in vivo. We measured the outdoor and indoor solar irradiances and found indoor solar UVA irradiances represent about 25% (or 5-10 W/m2) of the outdoor irradiances and are about 60 times greater than fluorescent light irradiances. We calculated the outdoor and indoor UV contributions toward different biological endpoints by weighting the emission spectra by the action spectra: erythema, squamous cell carcinoma, melanoma (fish), and previtamin D3. Furthermore, we found production of previtamin D3 only occurs outside where there is enough UVB. We agree that intense, intermittent outdoor UV overexposures and sunburns initiate CMM; we now propose that increased UVA exposures and inadequately maintained cutaneous levels of vitamin D3 promotes CMM.
KW - cholecalciferol
KW - cutaneous melanoma
KW - exposure
KW - human diseases
KW - melanoma
KW - neoplasms
KW - risk factors
KW - skin
KW - skin diseases
KW - solar radiation
KW - ultraviolet radiation
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - dermatoses
KW - dermis
KW - sunlight
KW - ultraviolet A radiation
KW - vitamin D3
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093089264&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN2-4VDGTP3-1&_user=6686535&_coverDate=04%2F30%2F2009&_rdoc=20&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236950%232009%23999279995%23941171%23FLA%23display%23Volume)&_cdi=6950&_sort=d&_docanchor=&_ct=44&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=b5968e33f40d5c7a31009e2996b92ae4
UR - email: DEG@CDRH.FDA.GOV
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Application of deadenylase electrochemiluminescence assay for ricin to foods in a plate format.
AU - Cho, C. Y.
AU - Keener, W. K.
AU - Garber, E. A. E.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 4
SP - 903
EP - 906
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cho, C. Y.: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20103047714. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 9009-86-3. Subject Subsets: Human Nutrition
N2 - A recently developed bead-based deadenylase electrochemiluminescence assay for ricin is simple and sensitive in its ability to detect ricin, based on the catalytic activity of the toxin subunit, ricin A chain. The assay was modified to work in a 96-well plate format and evaluated by using juice samples. The plate-based assay, unlike the bead-based assay, includes wash steps that enable the removal of food particles. These steps minimize matrix effects and improve the signal-to-noise ratios and limits of detection (LOD). The LOD values for ricin in apple juice, vegetable juice, and citrate buffer by using the bead-based assay were 0.4, 1, and 0.1 µg/ml, respectively. In contrast, the LOD values for ricin by using the plate-based assay were 0.04, 0.1, and 0.04 µg/ml in apple juice, vegetable juice, and citrate buffer, respectively. The plate-based assay displayed three- to 10-fold lower LOD values than did the bead-based assay. Signal-to-noise ratios for the plate-based assay were comparable to those for the bead-based assay for ricin in citrate buffer, but 2- to 4.5-fold higher when the plate-based assay was used for analysis of juice samples.
KW - apple juice
KW - chemiluminescence immunoassays
KW - food contamination
KW - ribonucleases
KW - ricin
KW - techniques
KW - vegetable juices
KW - deadenylase
KW - food contaminants
KW - RNASE
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103047714&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: Chung.Cho@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Interlaboratory validation of a real-time PCR 24-hour rapid method for detection of Salmonella in foods.
AU - Cheng, C. M.
AU - Van, K. T.
AU - Lin, W.
AU - Ruby, R. M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 5
SP - 945
EP - 951
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Cheng, C. M.: U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Southwest, 19701 Fairchild, Irvine, CA 92612, USA.
N1 - Accession Number: 20093158013. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Poultry; Medical & Veterinary Entomology; Dairy Science; Potatoes; Horticultural Science; Human Nutrition
N2 - The efficacy of a 24-h Salmonella real-time, or quantitative, PCR (qPCR) detection method was assessed through a collaborative effort involving eight Federal and state laboratories. Eleven foods including mashed potatoes, soft cheese, chili powder, chocolate, eggs, sprouts, apple juice, fish, shrimp, ground beef, and ground chicken were tested. For each food, seven blind samples were distributed to each participant for testing. These included six samples equivalently inoculated with 1 to 5 CFU/25 g of various serotypes of Salmonella (Gaminara, Weltevreden, Heidelberg, Senftenberg, Enteritidis, Newport, Typhimurium, and Kentucky for each food) and 10 to 50 CFU/25 g of the competitor Enterobacter cloacae. The seventh sample was inoculated with 10 to 50 CFU/25 g of the competitor, E. cloacae, only. These samples were tested for Salmonella by using four methods in parallel: (i) 24-h qPCR method detecting Salmonella from modified buffered peptone water enrichment medium; (ii) 48-h qPCR method detecting Salmonella from a secondary selective enrichment broth; (iii) modified Bacteriological Analytical Manual method; and (iv) VIDAS, an immunoassay system. The results of the statistical analysis showed there was no significant (P≥0.05) difference between either of the qPCR methods and the modified Bacteriological Analytical Manual method for 10 of 11 foods. For the one exception, sprouts, detection by qPCR required 48 h. Both qPCR methods showed a detection limit of 0.08 to 0.2 CFU/g. These results provide a solid basis for using this 24-h qPCR rapid screening method to detect Salmonella in foods.
KW - apple juice
KW - beef
KW - chocolate
KW - eggs
KW - fish
KW - food contamination
KW - food microbiology
KW - methodology
KW - microbial contamination
KW - polymerase chain reaction
KW - potatoes
KW - poultry
KW - serotypes
KW - shrimps
KW - soft cheese
KW - sprouts
KW - fowls
KW - Salmonella
KW - Solanum tuberosum
KW - Decapoda
KW - Malacostraca
KW - Crustacea
KW - arthropods
KW - invertebrates
KW - animals
KW - aquatic animals
KW - aquatic organisms
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - vertebrates
KW - Chordata
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - bacterium
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - methods
KW - PCR
KW - Milk and Dairy Produce (QQ010)
KW - Meat Produce (QQ030)
KW - Eggs and Egg Products (QQ040)
KW - Crop Produce (QQ050)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093158013&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: chorng-ming.cheng@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chlorine dioxide gas from an aqueous solution: reduction of Salmonella in wounds on tomato fruit and movement to sinks in a treatment chamber.
AU - Mahovic, M.
AU - Bartz, J. A.
AU - Schneider, K. R.
AU - Tenney, J. D.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 5
SP - 952
EP - 958
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Mahovic, M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.
N1 - Accession Number: 20093158014. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Registry Number: 10049-04-4. Subject Subsets: Postharvest Research; Human Nutrition
N2 - Chlorine dioxide (ClO2) off-gassed from an aqueous solution and reacted incrementally with potassium iodide solutions (sinks). After 30 min, 45% of the initial dose was detected as chlorite ion in the sink, whereas 35% of the initial dose was still in the source. Aqueous solutions of ClO2 can be used as a source of ClO2 gas in various laboratory experiments involving treatment of fruits or vegetables. Movement from source to sink is continuous, which precludes the development of large headspace concentrations and the need for a tight chamber seal. When the source solution has dissipated, the chamber can be opened safely as there is little free ClO2 remaining in the headspace. In tests with whole, wound-inoculated tomato fruit, at both green and pink stages of ripeness, the control of Salmonella enterica serotype Typhimurium in wounds varied with the weight of gas used. The number of viable cells of Typhimurium recovered was reduced by >5 log units when ≥0.5 mg of ClO2 was applied to three pieces of fruit during a 2-h treatment.
KW - chlorine dioxide
KW - food contamination
KW - food microbiology
KW - microbial contamination
KW - tomatoes
KW - Salmonella
KW - Solanum lycopersicum
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - food contaminants
KW - Lycopersicon esculentum
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093158014&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: softbart@ufl.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a macrophage cell culture method to isolate and enrich Francisella tularensis from food matrices for subsequent detection by real-time PCR.
AU - Day, J. B.
AU - Whiting, R. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 6
SP - 1156
EP - 1164
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Day, J. B.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-712, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093186738. Publication Type: Journal Article. Language: English. Number of References: 65 ref. Subject Subsets: Human Nutrition; Medical & Veterinary Entomology
N2 - Francisella tularensis is a gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are no techniques currently available to detect this organism in specific food matrices. In this study, a macrophage cell culture system is combined with real-time PCR to identify F. tularensis in food matrices. The method utilizes a mouse macrophage cell line (RAW 264.7) as host for the isolation and intracellular replication of F. tularensis. Exposure of macrophages to F. tularensis-contaminated food matrices results in uptake and intracellular replication of the bacteria, which can be subsequently detected by real-time PCR analysis of the DNA released from infected macrophage cell lysates. Macrophage monolayers were exposed to infant formula, liquid egg whites, and lettuce contaminated with varying quantities of F. tularensis. As few as 10 CFU/ml (or CFU per gram) F. tularensis was detected in infant formula and lettuce after 5 h postinfection. As few as 10 CFU/ml F. tularensis was detected in liquid egg whites after 18 h postinfection. Intracellular F. tularensis could also be isolated on Mueller-Hinton medium from lysates of macrophages infected with the bacteria in infant formula, liquid egg whites, and lettuce for subsequent confirmatory identification. This method is the first to successfully identify F. tularensis from select food matrices.
KW - analytical methods
KW - animal models
KW - cell culture
KW - cell lines
KW - detection
KW - food contamination
KW - foodborne diseases
KW - Gram negative bacteria
KW - laboratory animals
KW - macrophages
KW - microbial contamination
KW - polymerase chain reaction
KW - tularaemia
KW - Bacteria
KW - Francisella tularensis
KW - mice
KW - Bacteria
KW - prokaryotes
KW - Francisella
KW - Francisellaceae
KW - Thiotrichales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - analytical techniques
KW - bacterium
KW - food contaminants
KW - PCR
KW - tularemia
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093186738&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: james.day@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of enrichment procedures for Shiga toxin-producing Escherichia coli in wastes from commercial swine farms.
AU - Grant, M. A.
AU - Mogler, M. A.
AU - Harris, D. L.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 9
SP - 1982
EP - 1986
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Grant, M. A.: US Food and Drug Administration, Bothell, WA 98021-4421, USA.
N1 - Accession Number: 20113048776. Publication Type: Journal Article. Language: English. Number of References: 24 ref. Subject Subsets: Human Nutrition; Pig Science
N2 - Three methods for enrichment of Shiga toxin-producing Escherichia coli (STEC) were compared using waste pit samples from swine production facilities housing 50 to 3,000 animals. The STEC gene stx2 was detected in 5 of 17 pooled samples using a U.S. Department of Agriculture (USDA) enrichment procedure, 6 of 17 samples using a U.S. Food and Drug Administration (FDA) enrichment procedure, and 8 of 17 samples using an experimental acid enrichment. All isolates were non-O157 and 5 of 6 were positive for enterotoxigenic E. coli-associated heat stable toxins a and b. The three enrichment procedures were also tested for their ability to support growth of 31 strains of STEC. The acid enrichment media supported growth of 100% of the strains, the FDA medium supported 77% of the strains, and the USDA medium supported 16% of the strains.
KW - animal wastes
KW - culture media
KW - enterotoxigenic Escherichia coli
KW - genes
KW - methodology
KW - pig housing
KW - pig manure
KW - Shiga toxin-producing Escherichia coli
KW - strains
KW - ETEC
KW - livestock wastes
KW - methods
KW - piggeries
KW - STEC
KW - sties
KW - swine housing
KW - VTEC
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Animal Wastes (XX100)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113048776&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: mike.grant@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of DNA colony hybridization and real-time PCR for detection of Vibrio parahaemolyticus and Vibrio vulnificus in postharvest-processed oysters.
AU - Jones, J. L.
AU - Noe, K. E.
AU - Byars, R.
AU - DePaola, A.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 10
SP - 2106
EP - 2109
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Jones, J. L.: U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20113049104. Publication Type: Journal Article. Language: English. Number of References: 7 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - The applicability of real-time PCR was examined for detection of vibrios from postharvest-processed (PHP) oysters to allow for a more rapid assay and higher sample throughput than currently used. During June to October 2004, 68 PHP oyster samples were collected directly from PHP firms or from retail markets across the United States. PHP oysters were examined to determine the effectiveness of treatments in the reduction of vibrio levels and to compare the analytical methods utilized. The latter is the focus of the data presented here. Each sample was analyzed for Vibrio parahaemolyticus and V. vulnificus by using a 2-dilution, three-tube most-probable-number (MPN) and a 25-g presence/absence enrichment in alkaline peptone water. Following 6-h and overnight enrichment, aliquots from each MPN tube and the 25-g sample were streaked onto selective media and tested by real-time PCR. Colonies from the selective agar were confirmed as V. parahaemolyticus or V. vulnificus by DNA colony hybridization. DNA hybridization and real-time PCR results for each MPN tube and the 25-g enrichment at both time points were analyzed individually for each organism. The methods were in agreement for 857 (95%) of 901 and for 882 (98%) of 903 tubes for detection of V. parahaemolyticus and V. vulnificus, respectively. Overall, there was 96% agreement between real-time and DNA colony hybridization. The results obtained by real-time PCR were comparable to those from DNA colony hybridization, but analysis time was significantly reduced for the detection of vibrios in PHP-treated oysters.
KW - detection
KW - DNA
KW - DNA hybridization
KW - food contamination
KW - food safety
KW - microbial contamination
KW - oysters
KW - polymerase chain reaction
KW - real time PCR
KW - USA
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - deoxyribonucleic acid
KW - food contaminants
KW - PCR
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113049104&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: Jessica.Jones@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survey of postharvest-processed oysters in the United States for levels of Vibrio vulnificus and Vibrio parahaemolyticus.
AU - DePaola, A.
AU - Jones, J. L.
AU - Noe, K. E.
AU - Byars, R. H.
AU - Bowers, J. C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 10
SP - 2110
EP - 2113
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - DePaola, A.: U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA.
N1 - Accession Number: 20113049109. Publication Type: Journal Article. Language: English. Number of References: 14 ref.
N2 - From June through October 2004, the U.S. Food and Drug Administration collected oysters (61 samples) that had been subjected to postharvest processing (PHP) methods, including mild heat treatment, freezing, and high hydrostatic pressure, from processors and retail markets in various states to determine Vibrio vulnificus and V. parahaemolyticus levels. Presence in a 25-g sample and most probable number (MPN) using standard enrichment and selective isolation procedures were utilized. Suspect colonies were isolated and identified using DNA probe colony hybridization. Neither species of vibrio was detected in 25-g portions of most samples regardless of the PHP. The lowest frequency of isolation of either pathogen (<10%) was observed with the mild heat process. Few (12 to 13%) frozen samples collected at the processor but not at retail contained >30 MPN/g of either pathogen. The mean levels of either organism in PHP oysters observed in the present study were 5 to 6 log less than in unprocessed raw Gulf Coast oysters. Of the 70 V. vulnificus isolates examined, only 5 possessed the putative virulence marker, type B 16S rRNA. Neither the thermostable direct hemolysin (tdh) nor the tdh-related hemolysin (trh) virulence gene was detected in any of the 40 V. parahaemolyticus isolates examined in the present study. These data suggest that if there is any selective advantage to pathogenic strains of V. vulnificus and V. parahaemolyticus, these differences are minimal. These results indicate that all PHP treatments greatly reduce exposure of V. vulnificus and V. parahaemolyticus to raw-oyster consumers. Consequently, these PHP oysters pose a much lower risk of illness to consumers due to these pathogens.
KW - bacterial toxins
KW - food contamination
KW - food processing
KW - food safety
KW - freezing
KW - genes
KW - haemolysins
KW - heat treatment
KW - microbial contamination
KW - oysters
KW - pressure
KW - pressure treatment
KW - seafoods
KW - virulence
KW - virulence factors
KW - USA
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Bivalvia
KW - Mollusca
KW - invertebrates
KW - animals
KW - aquatic organisms
KW - aquatic animals
KW - eukaryotes
KW - Vibrio
KW - Vibrionaceae
KW - Vibrionales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - heat processing
KW - hemolysins
KW - United States of America
KW - Aquatic Produce (QQ060)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113049109&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: angelo.depaola@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of thermal processing during yogurt production upon the detection of staphylococcal enterotoxin B.
AU - Principato, M.
AU - Boyle, T.
AU - Njoroge, J.
AU - Jones, R. L., Jr.
AU - O'Donnell, M.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 10
SP - 2212
EP - 2216
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Principato, M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20113048872. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 75-07-0, 50-21-5. Subject Subsets: Dairy Science
N2 - This research was conducted to examine the inherent properties of yogurt contaminated with staphylococcal enterotoxin B (SEB). Two types of yogurts were produced for this study. Type I yogurts were produced by adding SEB at the start of yogurt production, and type II yogurts were produced by adding SEB after the milk base had been boiled. Biochemical characteristics inherent to yogurt, including pH, lactic acid and acetaldehyde concentrations, were analyzed weekly for each batch beginning at a time just after production and throughout a storage period of at least 4 weeks. The presence of toxin during yogurt production did not result in any significant biochemical or physical changes in yogurt. However, we were unable to detect SEB toxin in type I yogurt using a commercially available enzyme-linked immunosorbent assay (ELISA). In contrast, SEB was easily detectable by our ELISA in type II yogurt samples. Higher levels of SEB were recovered from type II yogurt that had been stored for 1 week than from type II yogurt that had been stored for any other length of time. These results indicate that the biochemical characteristics of yogurt did not change significantly (relative to control yogurt) in the presence of either thermally processed SEB or native SEB. However, the ability to detect SEB by ELISA was dependent on whether the toxin had been processed.
KW - acetaldehyde
KW - chemical properties
KW - enterotoxins
KW - food contamination
KW - food safety
KW - heat treatment
KW - lactic acid
KW - microbial contamination
KW - pH
KW - yoghurt
KW - food contaminants
KW - heat processing
KW - hydrogen ion concentration
KW - joghurt
KW - lactate
KW - potential of hydrogen
KW - staphylococcal enterotoxin B
KW - yogurt
KW - Milk and Dairy Produce (QQ010)
KW - Food Processing (General) (QQ100)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Toxinology (VV820) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113048872&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: maryann.principato@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development, evaluation, and peer verification of a rapid real-time PCR method for the detection of animal material.
AU - Yancy, H. F.
AU - Washington, J. D.
AU - Callahan, L.
AU - Mason, J. A.
AU - Deaver, C. M.
AU - Farrell, D. E.
AU - Ha, T.
AU - Sespico, E.
AU - Falmlen, D.
AU - Myers, M. J.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 11
SP - 2368
EP - 2374
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Yancy, H. F.: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20113049395. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition; Poultry; Agricultural Biotechnology; Animal Nutrition; Animal Breeding; Pig Science
N2 - Four real-time PCR assays that can be used with U.S.- and European Union-rendered materials to detect three ruminant species (bovine, caprine, and ovine) and a select set of avians (chicken, goose, and turkey) were developed. This method was evaluated against stringent acceptance criteria previously developed by the U.S. Food and Drug Administration, Center for Veterinary Medicine's Office of Research. Acceptance criteria for determining success used a statistical approach requiring a 90% probability of achieving the correct response, within a 95% confidence interval. A minimum detection level of 0.1% meat and bone meal (MBM) was required, consistent with the sensitivity of the validated PCR-based method currently used by the U.S. Food and Drug Administration as an aid in enforcement of the Agency's feed ban. PCR primer specificity was determined by using a panel of DNA samples derived from 16 different animal species. The method is able to detect 0.1% rendered material in complete feed in less than 1.5 h of total assay time, a significant improvement over the current method, which requires 7 to 8 h for completion. The real-time assay for the detection of animal material passed stringent acceptance criteria for sensitivity, selectivity, and specificity. The method also passed ruggedness, real-time platform, and second analyst trials. Two external laboratories participating in a peer-verification trial demonstrated 100% specificity in identifying bovine MBM, ovine MBM, or caprine meat meal, while exhibiting a 0.6% rate of false positives. These results demonstrated that this method was capable of being used by other laboratories.
KW - detection
KW - DNA
KW - feeds
KW - meat and bone meal
KW - meat meal
KW - polymerase chain reaction
KW - poultry
KW - real time PCR
KW - cattle
KW - fowls
KW - geese
KW - goats
KW - pigs
KW - sheep
KW - turkeys
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Anser
KW - Anatidae
KW - Anseriformes
KW - Capra
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Ovis
KW - Meleagris
KW - chickens
KW - deoxyribonucleic acid
KW - domesticated birds
KW - feeding stuffs
KW - hogs
KW - PCR
KW - swine
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Feed Composition and Quality (RR300)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113049395&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: Hyancy@cvm.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Survival of hepatitis A virus in spinach during low temperature storage.
AU - Shieh, Y. C.
AU - Stewart, D. S.
AU - Laird, D. T.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009///
VL - 72
IS - 11
SP - 2390
EP - 2393
CY - Des Moines; USA
PB - International Association for Food Protection
SN - 0362-028X
AD - Shieh, Y. C.: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA.
N1 - Accession Number: 20113049043. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Horticultural Science
N2 - Spinach leaves are frequently consumed raw and have been involved with past foodborne outbreaks. In this study, we examined the survival of hepatitis A virus (HAV) on fresh spinach leaves in moisture- and gas-permeable packages that were stored at 5.4±1.2°C for up to 42 days. Different eluents including phosphate-buffered saline (PBS), pH 7.5 (with and without 2% serum), and 3% beef extract (pH 7.5 and 8) were compared for how efficiently they recovered viruses from spinach by using a simple elution procedure (<1 h). The recoveries were compared and determined by a plaque assay with FRhK-4 cells. Culture grade PBS containing 2% serum was found to be appropriate for HAV elution from spinach leaves, with an average recovery of 45%±10%. Over 4 weeks of storage at 5.4±1.2°C, HAV in spinach decreased slightly more than 1 log, with 6.75% of the original titer remaining. HAV survived under refrigerated temperatures on spinach leaves with a D-value of 28.6 days (equivalent to an inactivation rate of -0.035 log of HAV per day, r2=0.88). In comparison, HAV in PBS containing 2% serum under the same storage conditions remained constant throughout 7 weeks. The inactivation rate of -0.035 log each day for HAV on spinach leaves was possibly due to the interaction of the virus and the leaf.
KW - cold storage
KW - food contamination
KW - food storage
KW - fresh products
KW - inactivation
KW - leaves
KW - microbial contamination
KW - refrigeration
KW - spinach
KW - survival
KW - Hepatitis A virus
KW - Spinacia oleracea
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - food contaminants
KW - Horticultural Crops (FF003) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Storage and Preservation (QQ110)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113049043&site=ehost-live&scope=site
UR - http://www.foodprotection.org
UR - email: carol.shieh@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Assessment of heavy metal exposure via the intake of oriental medicines in Korea.
AU - Kim HyunKyung
AU - Yoon EunKyung
AU - Jang JungHoon
AU - Hwang MyungSil
AU - Kim JaYoung
AU - Ha JiHye
AU - Jang DongDeuk
AU - Yoo TaeMoo
AU - Park KuiLea
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2009///
VL - 72
IS - 21/22
SP - 1336
EP - 1342
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Kim HyunKyung: Risk Assessment Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20093361589. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Registry Number: 7440-43-9, 7439-92-1. Subject Subsets: Aromatic & Medicinal Plants; Tropical Diseases
N2 - Oriental medical herbs are mainly natural products that are generated by simple processes, and therefore there is the possibility of contamination with various pollutants, including heavy metals. Heavy metals produce adverse effects in humans, and the toxicities of lead (Pb) and cadmium (Cd) are well established. This study evaluated the effects of exposure to Pb and Cd via the intake of the frequent prescriptions of oriental medicines, and assessed the risk to the Korean population based on domestic data. The average daily exposures to Pb and Cd were estimated. This is the first study to evaluate exposure and risk of heavy metal intoxication through intake of oriental medicines in Korea. Despite the uncertainties and limits of the data, these results simulate realistic exposure levels.
KW - cadmium
KW - exposure
KW - heavy metals
KW - herbal drugs
KW - intake
KW - lead
KW - medicinal plants
KW - toxic substances
KW - traditional medicines
KW - Korea Republic
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - OECD Countries
KW - Threshold Countries
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - poisons
KW - South Korea
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093361589&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: parkkl@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Metabolomics approach to risk assessment: methoxyclor exposure in rats.
AU - Kim KyuBong
AU - Kim SeonHwa
AU - Um SoYoung
AU - Chung MyeonWoo
AU - Oh JiSeon
AU - Jung SeungChul
AU - Kim TaeSung
AU - Moon HyunJoo
AU - Han SoonYoung
AU - Oh HyeYoung
AU - Lee ByungMu
AU - Choi KiHwan
JO - Journal of Toxicology and Environmental Health. Part A
JF - Journal of Toxicology and Environmental Health. Part A
Y1 - 2009///
VL - 72
IS - 21/22
SP - 1352
EP - 1368
CY - Philadelphia; USA
PB - Taylor & Francis
SN - 1528-7394
AD - Kim KyuBong: National Institute of Toxicological Research, Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20093361595. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Registry Number: 72-43-5. Subject Subsets: Agricultural Entomology; Soyabeans
N2 - The primary objective of this study was to develop exposure biomarkers that "correlate with the endocrine-disrupting effects induced by methoxyclor (MTC), an organochlorine pesticide, using" urinary 1H nuclear magnetic resonance (NMR) spectral data. Exposure biomarkers play an important role in risk assessment. MTC is an environmental endocrine disruptor with estrogenic, anti-estrogenic, and anti-androgenic properties. A new approach of proton nuclear magnetic resonance (1H NMR) urinalysis using pattern recognition was proposed for exposure biomarkers of MTC in female rats. The endocrine disruptor was expected to induce estrogenic effects in a dose dependent mamer which, was confirmed by the uterotrophic assay. MTC [50, 100, or 200 m g/kg/d, orally (po) or subcutaneously (sc)] was administered to ovarectomized female Sprague-Dawley (SD) rats for 3 d consecutively and urine was collected every 24 h. The animals were sacrificed 24 h after the last dose. All animals treated orally with MTC showed a significant increase in uterine and vaginal weight at all doses. However, in the sc route, only a high dose of 200 mg MTC/kg induced a significant increase in uterine and vaginal weight 1H NMR spectroscopy revealed evident separate clustering between pre- and post-treatment groups using global metabolic profiling through principal component analysis (PCA) and partial least square (PLS) discrimination analysis (DA) after different exposure routes. With targeted profiling, the endogenous metabolites of acetate, alanine, benzoate, lactate, and glycine were selected as putative exposure biomarkers for MTC. Data suggest that the proposed putative exposure biomarkers may be useful in a risk assessment of the endocrine-disrupting effects produced by MTC.
KW - animal models
KW - insecticide residues
KW - insecticides
KW - metabolomics
KW - methoxychlor
KW - risk assessment
KW - statistical analysis
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - statistical methods
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093361595&site=ehost-live&scope=site
UR - http://taylorandfrancis.metapress.com/link.asp?id=100675
UR - email: hyokwa@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and characterization of class 1 integron resistance gene cassettes among Salmonella strains isolated from imported seafood.
AU - Khan, A. A.
AU - Ponce, E.
AU - Nawaz, M. S.
AU - Cheng, C. M.
AU - Khan, J. A.
AU - West, C. S.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2009///
VL - 75
IS - 4
SP - 1192
EP - 1196
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Khan, A. A.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093117023. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Registry Number: 57-92-1, 723-46-6, 738-70-5. Subject Subsets: Human Nutrition
N2 - A total of 210 Salmonella isolates, representing 64 different serovars, were isolated from imported seafood samples, and 55/210 isolates were found to be resistant to at least one antibiotic. Class 1 integrons from three multidrug-resistant Salmonella enterica strains (Salmonella enterica serovars Newport [strain 62], Typhimurium var. Copenhagen [strain 629], and Lansing [strain 803], originating from Hong Kong, the Philippines, and Taiwan, respectively) were characterized. Southern hybridization of plasmids isolated from these strains, using a class 1 integron probe, showed that trimethoprim-sulfamethoxazole and streptomycin resistance genes were located on a megaplasmid in strain 629. Our study indicates that imported seafood could be a reservoir for Salmonella isolates resistant to multiple antibiotics.
KW - antibiotics
KW - drug resistance
KW - food contamination
KW - genes
KW - microbial contamination
KW - plasmids
KW - salmonellosis
KW - seafoods
KW - serovars
KW - strains
KW - streptomycin
KW - sulfamethoxazole
KW - trimethoprim
KW - China
KW - Hong Kong
KW - Philippines
KW - Taiwan
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developing Countries
KW - East Asia
KW - Asia
KW - Central Southern China
KW - China
KW - ASEAN Countries
KW - South East Asia
KW - Developed Countries
KW - bacterium
KW - food contaminants
KW - Formosa
KW - People's Republic of China
KW - Salmonella infections
KW - sulphamethoxazole
KW - Xianggang
KW - Pesticide and Drug Resistance (HH410)
KW - Aquatic Produce (QQ060)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093117023&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: Ashraf.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice.
AU - Zhou Yun
AU - Peng Ling
AU - Zhang WeiDong
AU - Kong DeYun
JO - Planta Medica
JF - Planta Medica
Y1 - 2009///
VL - 75
IS - 6
SP - 568
EP - 574
CY - Stuttgart; Germany
PB - Georg Thieme Verlag
SN - 0032-0943
AD - Zhou Yun: Zhejiang Food and Drug Administration, No. 27 Wenbei Lane, Moganshan Road, Hangzhou 310012, Zhejiang Province, China.
N1 - Accession Number: 20093162361. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Three new saponins, bacopasides IX-XI (1-3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.
KW - animal models
KW - herbal drugs
KW - medicinal plants
KW - medicinal properties
KW - plant extracts
KW - saponins
KW - triterpenoid saponins
KW - Bacopa monnieri
KW - mice
KW - Bacopa
KW - Scrophulariaceae
KW - Scrophulariales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - drug plants
KW - herbal medicines
KW - medicinal herbs
KW - officinal plants
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093162361&site=ehost-live&scope=site
UR - http://www.thieme-connect.com/ejournals/toc/plantamedica
UR - email: yunzhoucn@yahoo.com.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of live Salmonella sp. cells in produce by a TaqMan-based quantitative reverse transcriptase real-time PCR targeting invA mRNA.
AU - González-Escalona, N.
AU - Hammack, T. S.
AU - Russell, M.
AU - Jacobson, A. P.
AU - Jesús, A. J. de
AU - Brown, E. W.
AU - Lampel, K. A.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2009///
VL - 75
IS - 11
SP - 3714
EP - 3720
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - González-Escalona, N.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway HFS-712, College Park, MD 20740, USA.
N1 - Accession Number: 20093205687. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Subject Subsets: Human Nutrition; Postharvest Research
N2 - Salmonella enterica contamination in foods is a significant concern for public health. When DNA detection methods are used for analysis of foods, one of the major concerns is false-positive results from the detection of dead cells. To circumvent this crucial issue, a TaqMan quantitative real-time RT-PCR (qRT-PCR) assay with an RNA internal control was developed. invA RNA standards were used to determine the detection limit of this assay as well as to determine invA mRNA levels in mid-exponential-, late-exponential-, and stationary-phase cells. This assay has a detection limit of 40 copies of invA mRNA per reaction. The levels of invA mRNA in mid-exponential-, late-exponential-, and stationary-phase S. enterica cells was approximately 1 copy per 3 CFU, 1 copy per CFU, and 4 copies per 103 CFU, respectively. Spinach, tomatoes, jalapeno peppers, and serrano peppers were artificially contaminated with four different Salmonella serovars at levels of 105 and less than 10 CFU. These foods were analyzed with qRT-PCR and with the FDA's Bacteriological Analytical Manual Salmonella culture method (W. A. Andrews and T. S. Hammack, in G. J. Jackson et al., ed., Bacteriological analytical manual online, http://www.cfsan.fda.gov/~ebam/bam-5.html, 2007). Comparable results were obtained by both methods. Only live Salmonella cells could be detected by this qRT-PCR assay, thus avoiding the dangers of false-positive results from nonviable cells. False negatives (inhibition of the PCR) were also ruled out through the use of an RNA internal control. This assay allows for the fast and accurate detection of viable Salmonella spp. in spinach, tomatoes, and in both jalapeno and serrano peppers.
KW - cells
KW - detection
KW - food contamination
KW - messenger RNA
KW - microbial contamination
KW - molecular genetics techniques
KW - pepper
KW - polymerase chain reaction
KW - spinach
KW - tomatoes
KW - Salmonella enterica
KW - Solanum lycopersicum
KW - Spinacia oleracea
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - bacterium
KW - food contaminants
KW - Lycopersicon esculentum
KW - mRNA
KW - PCR
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093205687&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: narjol.gonzalez-escalona@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Recovery efficiency and limit of detection of aerosolized Bacillus anthracis Sterne from environmental surface samples.
AU - Estill, C. F.
AU - Baron, P. A.
AU - Beard, J. K.
AU - Hein, M. J.
AU - Larsen, L. D.
AU - Rose, L.
AU - Schaefer, F. W., III
AU - Noble-Wang, J.
AU - Hodges, L.
AU - Lindquist, H. D. A.
AU - Deye, G. J.
AU - Arduino, M. J.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2009///
VL - 75
IS - 13
SP - 4297
EP - 4306
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Estill, C. F.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, MS R-14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093250397. Publication Type: Journal Article. Language: English. Number of References: 38 ref. Registry Number: 12597-69-2. Subject Subsets: Public Health
N2 - After the 2001 anthrax incidents, surface sampling techniques for biological agents were found to be inadequately validated, especially at low surface loadings. We aerosolized Bacillus anthracis Sterne spores within a chamber to achieve very low surface loading (ca. 3, 30, and 200 CFU per 100 cm2). Steel and carpet coupons seeded in the chamber were sampled with swab (103 cm2) or wipe or vacuum (929 cm2) surface sampling methods and analyzed at three laboratories. Agar settle plates (60 cm2) were the reference for determining recovery efficiency (RE). The minimum estimated surface concentrations to achieve a 95% response rate based on probit regression were 190, 15, and 44 CFU/100 cm2 for sampling steel surfaces and 40, 9.2, and 28 CFU/100 cm2 for sampling carpet surfaces with swab, wipe, and vacuum methods, respectively; however, these results should be cautiously interpreted because of high observed variability. Mean REs at the highest surface loading were 5.0%, 18%, and 3.7% on steel and 12%, 23%, and 4.7% on carpet for the swab, wipe, and vacuum methods, respectively. Precision (coefficient of variation) was poor at the lower surface concentrations but improved with increasing surface concentration. The best precision was obtained with wipe samples on carpet, achieving 38% at the highest surface concentration. The wipe sampling method detected B. anthracis at lower estimated surface concentrations and had higher RE and better precision than the other methods. These results may guide investigators to more meaningfully conduct environmental sampling, quantify contamination levels, and conduct risk assessment for humans.
KW - aerosols
KW - bacterial spores
KW - carpet
KW - detection
KW - environment
KW - sampling
KW - steel
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - sampling techniques
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093250397&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: CEstill@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Development of a cell culture method to isolate and enrich Salmonella enterica serotype enteritidis from shell eggs for subsequent detection by real-time PCR.
AU - Day, J. B.
AU - Basavanna, U.
AU - Sharma, S. K.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2009///
VL - 75
IS - 16
SP - 5321
EP - 5327
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Day, J. B.: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093257885. Publication Type: Journal Article. Language: English. Number of References: 41 ref. Registry Number: 9007-49-2. Subject Subsets: Veterinary Science; Veterinary Science
N2 - Salmonella enterica serotype Enteritidis is a major cause of nontyphoidal salmonellosis from ingestion of contaminated raw or undercooked shell eggs. Current techniques used to identify Salmonella serotype Enteritidis in eggs are extremely laborious and time-consuming. In this study, a novel eukaryotic cell culture system was combined with real-time PCR analysis to rapidly identify Salmonella serotype Enteritidis in raw shell eggs. The system was compared to the standard microbiological method of the International Organization for Standardization (Anonymous, Microbiology of food and animal feeding stuffs - horizontal method for the detection of Salmonella, 2002). The novel technique utilizes a mouse macrophage cell line (RAW 264.7) as the host for the isolation and intracellular replication of Salmonella serotype Enteritidis. Exposure of macrophages to Salmonella serotype Enteritidis-contaminated eggs results in uptake and intracellular replication of the bacterium, which can subsequently be detected by real-time PCR analysis of the DNA released after disruption of infected macrophages. Macrophage monolayers were exposed to eggs contaminated with various quantities of Salmonella serotype Enteritidis. As few as 10 CFU/ml was detected in cell lysates from infected macrophages after 10 h by real-time PCR using primer and probe sets specific for DNA segments located on the Salmonella serotype Enteritidis genes sefA and orgC. Salmonella serotype Enteritidis could also be distinguished from other non-serogroup D Salmonella serotypes by using the sefA- and orgC-specific primer and probe sets. Confirmatory identification of Salmonella serotype Enteritidis in eggs was also achieved by isolation of intracellular bacteria from lysates of infected macrophages on xylose lysine deoxycholate medium. This method identifies Salmonella serotype Enteritidis from eggs in less than 10 h compared to the more than 5 days required for the standard reference microbiological method of the International Organization for Standardization (Microbiology of food and animal feeding stuffs - horizontal method for the detection of Salmonella, 2002).
KW - cell culture
KW - cell lines
KW - detection
KW - DNA
KW - egg shell
KW - eggs
KW - methodology
KW - polymerase chain reaction
KW - techniques
KW - Maryland
KW - USA
KW - Salmonella enteritidis
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - deoxyribonucleic acid
KW - methods
KW - PCR
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000)
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093257885&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: james.day@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - β-Lactam resistance in Salmonella strains isolated from retail meats in the United States by the national antimicrobial resistance monitoring system between 2002 and 2006.
AU - Zhao, S.
AU - Blickenstaff, K.
AU - Glenn, A.
AU - Ayers, S. L.
AU - Friedman, S. L.
AU - Abbott, J. W.
AU - McDermott, P. F.
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
Y1 - 2009///
VL - 75
IS - 24
SP - 7624
EP - 7630
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0099-2240
AD - Zhao, S.: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland FDA/CVM, 8401 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20103031237. Publication Type: Journal Article. Language: English. Number of References: 36 ref. Registry Number: 26787-78-0, 34642-77-8, 61336-70-7, 69-52-3, 69-53-4, 7177-48-2, 78110-38-0, 60846-21-1, 64485-93-4, 33564-30-6, 35607-66-0, 84957-30-2, 72558-82-8, 80370-57-6, 73384-59-5, 74578-69-1, 58001-44-8, 64221-86-9, 61477-96-1, 89786-04-9. Subject Subsets: Human Nutrition
N2 - Ampicillin-resistant (Ampr) Salmonella enterica isolates (n=344) representing 32 serotypes isolated from retail meats from 2002 to 2006 were tested for susceptibility to 21 other antimicrobial agents and screened for the presence of five beta-lactamase gene families (blaCMY, blaTEM, blaSHV, blaOXA, and blaCTX-M) and class 1 integrons. Among the Ampr isolates, 66.9% were resistant to five or more antimicrobials and 4.9% were resistant to 10 or more antimicrobials. Coresistance to other β-lactams was noted for amoxicillin-clavulanic acid (55.5%), ceftiofur (50%), cefoxitin (50%), and ceftazidime (24.7%), whereas less than 5% of isolates were resistant to piperacillin-tazobactam (4.9%), cefotaxime (3.5%), ceftriaxone (2%), and aztreonam (1.2%). All isolates were susceptible to cefepime, imipenem, and cefquinome. No Salmonella producing extended-spectrum beta-lactamases was found in this study. Approximately 7% of the isolates displayed a typical multidrug-resistant (MDR)-AmpC phenotype, with resistance to ampicillin, chloramphenicol, streptomycin, sulfonamide, tetracycline, plus resistance to amoxicillin-clavulanic acid, cefoxitin, and ceftiofur and with decreased susceptibility to ceftriaxone (MIC ≥4 µg/ml). Pulsed-field gel electrophoresis results showed that several MDR clones were geographically dispersed in different types of meats throughout the five sampling years. Additionally, 50% of the isolates contained blaCMY, 47% carried blaTEM-1, and 2.6% carried both genes. Only 15% of the isolates harbored class I integrons carrying various combinations of aadA, aadB, and dfrA gene cassettes. The blaCMY, blaTEM, and class 1 integrons were transferable through conjugation and/or transformation. Our findings indicate that a varied spectrum of coresistance traits is present in AmprSalmonella strains in the meat supply of the United States, with a continued predominance of blaCMY and blaTEM genes in β-lactam-resistant isolates.
KW - amoxicillin
KW - ampicillin
KW - antibacterial agents
KW - antiinfective agents
KW - aztreonam
KW - beta-lactam antibiotics
KW - cefotaxime
KW - cefoxitin
KW - cefquinome
KW - ceftazidime
KW - ceftiofur
KW - ceftriaxone
KW - clavulanic acid
KW - drug resistance
KW - food contamination
KW - food microbiology
KW - genes
KW - imipenem
KW - meat
KW - microbial contamination
KW - molecular genetics
KW - multiple drug resistance
KW - piperacillin
KW - retail marketing
KW - tazobactam
KW - USA
KW - Salmonella
KW - Salmonella enterica
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - amoxycillin
KW - antimicrobials
KW - bacterium
KW - biochemical genetics
KW - food contaminants
KW - United States of America
KW - Pesticide and Drug Resistance (HH410)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103031237&site=ehost-live&scope=site
UR - http://aem.asm.org
UR - email: shaohua.zhao@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Cumulative exposure estimates for polychlorinated biphenyls using a job-exposure matrix.
AU - Hopf, N. B.
AU - Waters, M. A.
AU - Ruder, A. M.
JO - Chemosphere
JF - Chemosphere
Y1 - 2009///
VL - 76
IS - 2
SP - 185
EP - 193
CY - Oxford; UK
PB - Elsevier
SN - 0045-6535
AD - Hopf, N. B.: National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20093150094. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health
N2 - PCB exposure has been associated with increased risk for cancer, neurological disease, and for birth defects in children exposed in utero. Because of the long half-lives of PCB congeners, they remain a public health problem in the United States 30 years after being banned. Workers (n=3569) at an Indiana capacitor manufacturing plant were exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The purpose of this work was to develop a period-specific job-exposure matrix (JEM) for a follow-up epidemiologic study investigating the increased risks for cancer previously observed in the cohort. Methods: We used eight exposure determinants to estimate PCB exposures systematically. Work history, job description, capacitor production factors, PCB usage trends, and air sample data were used to develop the JEM in four steps: (1) all job titles (n=884) were assessed for exposure determinants, (2) jobs with similar exposure determinants were grouped, (3) for each job exposure category, exposure intensity (high-medium-low-background) and frequency (continuous-intermittent) were qualitatively rated separately for inhalation and dermal exposure, and (4) for each job exposure category, the product of intensity (based on air sampling data) and frequency (fraction of day exposed) was calculated. The JEM was then modified for two eras of different PCB exposure conditions. Results: The resulting JEM consists of inhalation and dermal exposure values for 19 job exposure categories. Conclusion: The JEM showed an exposure-response trend associated with increased brain cancer mortality in the epidemiologic study.
KW - epidemiology
KW - exposure
KW - human diseases
KW - mortality
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - polychlorinated biphenyls
KW - risk factors
KW - workers
KW - Indiana
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - cancers
KW - death rate
KW - PCBs
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093150094&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V74-4W50JWS-C&_user=6686535&_coverDate=06%2F30%2F2009&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235832%232009%23999239997%231110053%23FLA%23display%23Volume)&_cdi=5832&_sort=d&_docanchor=&_ct=20&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=fa1681c22f5787dae7c0af6855cd1bfb
UR - email: NancyBHopf@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.
AU - Loving, C. L.
AU - Khurana, T.
AU - Osorio, M.
AU - Lee, G. M.
AU - Kelly, V. K.
AU - Stibitz, S.
AU - Merkel, T. J.
JO - Infection and Immunity
JF - Infection and Immunity
Y1 - 2009///
VL - 77
IS - 1
SP - 255
EP - 265
CY - Washington; USA
PB - American Society for Microbiology (ASM)
SN - 0019-9567
AD - Loving, C. L.: Laboratory of Respiratory and Special Pathogens Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093048776. Publication Type: Journal Article. Language: English. Number of References: 65 ref.
N2 - Anthrax toxins significantly contribute to anthrax disease pathogenesis, and mechanisms by which the toxins affect host cellular responses have been identified with purified toxins. However, the contribution of anthrax toxin proteins to dissemination, disease progression, and subsequent immunity after aerosol infection with spores has not been clearly elucidated. To better understand the role of anthrax toxins in pathogenesis in vivo and to investigate the contribution of antibody to toxin proteins in protection, we completed a series of in vivo experiments using a murine aerosol challenge model and a collection of in-frame deletion mutants lacking toxin components. Our data show that after aerosol exposure to Bacillus anthracis spores, anthrax lethal toxin was required for outgrowth of bacilli in the draining lymph nodes and subsequent progression of infection beyond the lymph nodes to establish disseminated disease. After pulmonary exposure to anthrax spores, toxin expression was required for the development of protective immunity to a subsequent lethal challenge. However, immunoglobulin (immunoglobulin G) titers to toxin proteins, prior to secondary challenge, did not correlate with the protection observed upon secondary challenge with wild-type spores. A correlation was observed between survival after secondary challenge and rapid anamnestic responses directed against toxin proteins. Taken together, these studies indicate that anthrax toxins are required for dissemination of bacteria beyond the draining lymphoid tissue, leading to full virulence in the mouse aerosol challenge model, and that primary and anamnestic immune responses to toxin proteins provide protection against subsequent lethal challenge. These results provide support for the utility of the mouse aerosol challenge model for the study of inhalational anthrax.
KW - animal models
KW - anthrax
KW - bacterial spores
KW - bacterial toxins
KW - disease course
KW - disseminated infections
KW - experimental infections
KW - immune response
KW - immunopathology
KW - infectivity
KW - laboratory animals
KW - mutants
KW - pathogenesis
KW - survival
KW - virulence
KW - Bacillus anthracis
KW - mice
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterium
KW - disease progression
KW - immunity reactions
KW - immunological reactions
KW - immunopathogenesis
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093048776&site=ehost-live&scope=site
UR - http://iai.asm.org/
UR - email: merkel@cber.fda.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The Chesson strain of Plasmodium vivax in humans and different species of Aotus monkeys.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Jeffery, G. M.
AU - Williams, A.
AU - Galland, G. G.
AU - Nace, D.
AU - Williams, T.
AU - Barnwell, J. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2009///
VL - 80
IS - 1
SP - 152
EP - 159
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, US Public Health Service, 4770 Buford Highway, Chamblee, GA 30341, USA.
N1 - Accession Number: 20093071067. Publication Type: Journal Article. Language: English. Number of References: 79 ref. Subject Subsets: Tropical Diseases; Protozoology
N2 - Comparison was made between the parasitemia of Chesson strain Plasmodium vivax in humans and in splenectomized Aotus lemurinus griseimembra, A. nancymaae, A. vociferans, and A. azarae boliviensis monkeys. In the monkeys, 56.3% of the animals had maximum counts >25 000/µL and in humans 59.6% were above this peak parasitemia. In humans, it took an average of 9.3 days to reach the maximum parasite count. In monkeys with no previous infections, it took an average of 18.9 days to reach the maximum parasite count; for those with previous infections, it took an average of 15 days. Human and nonhuman primate data on this parasite suggest that splenectomized Aotus monkeys, particularly A. lemurinus griseimembra, and to a somewhat lesser extent A. vociferans, can mimic the course of Chesson malaria in humans regarding parasitemia and mosquito infection.
KW - animal models
KW - human diseases
KW - laboratory animals
KW - malaria
KW - parasitaemia
KW - USA
KW - Aotus
KW - Aotus lemurinus
KW - Aotus vociferans
KW - man
KW - Plasmodium vivax
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - Aotus
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Aotus azarae boliviensis
KW - Aotus azarai
KW - Aotus lemurinus griseimembra
KW - Aotus nancymaae
KW - parasitemia
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093071067&site=ehost-live&scope=site
UR - http://www.ajtmh.org
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Studies on the Salvador I strain of Plasmodium vivax in non-human primates and anopheline mosquitoes.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Strobert, E.
AU - Galland, G. G.
AU - Williams, A.
AU - Nace, D.
AU - Williams, T.
AU - Barnwell, J. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2009///
VL - 80
IS - 2
SP - 228
EP - 235
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Geographic Medicine and Health Promotion and Animal Resources Branches, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20093085816. Publication Type: Journal Article. Language: English. Number of References: 37 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - A review is presented on studies conducted in New World monkeys and chimpanzees with the Salvador I strain of Plasmodium vivax. This isolate has been adapted to Aotus and Saimiri (squirrel) monkeys and developed as a model for the testing of antimalarial vaccines. After the injection of 10 000 sporozoites, the median prepatent period in S. boliviensis monkeys was 21.5 days. In 103 sporozoite-induced infections in splenectomized monkeys, the median maximum parasite count ranged from 2139 to 202 368/µl, with a median maximum parasite count of 48 174/µl. Median maximum parasite counts in Aotus lemurinus griseimembra, A. nancymaae, A. azarae boliviensis, and A. vociferans monkeys were 19 902, 18 390, 21 420, and 18 210/µl, respectively and ranged from 124 to 156 000/µl. Mosquito infections were readily obtained in different species of Anopheles mosquitoes. The S. boliviensis monkey and Salvador I strain seems suitable for the testing of sporozoite and liver stage vaccines but not for blood-stage vaccines against P. vivax unless adapted further in spleen-intact Saimiri boliviensis monkeys.
KW - animal models
KW - immunization
KW - malaria
KW - reviews
KW - spleen
KW - sporozoites
KW - strains
KW - vaccination
KW - vaccine development
KW - vaccines
KW - Anopheles
KW - Aotus
KW - Aotus lemurinus
KW - Aotus vociferans
KW - chimpanzees
KW - monkeys
KW - Plasmodium vivax
KW - Primates
KW - Saimiri
KW - Saimiri boliviensis
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Pan
KW - Pongidae
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Saimiri
KW - Aotus
KW - Aotus azarae boliviensis
KW - Aotus azarai
KW - Aotus lemurinus griseimembra
KW - Aotus nancymaae
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093085816&site=ehost-live&scope=site
UR - http://www.ajtmh.org
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Plasmodium fieldi: observations on the Hackeri and ABI strains in Macaca mulatta monkeys and mosquitoes.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Warren, M.
AU - Galland, G. G.
AU - Williams, A.
AU - Barnwell, J. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2009///
VL - 80
IS - 5
SP - 739
EP - 744
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases and Scientific Resources Branch, National Center for Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20093180480. Publication Type: Journal Article. Language: English. Number of References: 44 ref. Subject Subsets: Medical & Veterinary Entomology; Protozoology
N2 - In this study, Macaca mulatta monkeys infected with the Hackeri strain of Plasmodium fieldi had maximum parasite counts ranging from 1300 to 301 320/µl. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57 189/µl (median, 15 100/µl); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350 000/µl (median=52 245/µl). Transmission through Anopheles dirus mosquitoes was obtained on 11 occasions with pre-patent periods of 9-14 days. Relapses occurred between two and eight times during a 1-year period. Thus, P. fieldi has potential for testing prophylactic and radical curative drugs.
KW - disease models
KW - disease vectors
KW - experimental infections
KW - human diseases
KW - laboratory animals
KW - malaria
KW - mosquito-borne diseases
KW - parasitaemia
KW - relapse
KW - splenectomy
KW - Anopheles dirus
KW - Macaca mulatta
KW - Plasmodium fieldi
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Macaca
KW - Cercopithecidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - parasitemia
KW - recurrence of disease
KW - relapses
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093180480&site=ehost-live&scope=site
UR - http://www.ajtmh.org
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Possible involvement of the hypothalamic pro-opiomelanocortin gene and β-endorphin expression on acute morphine withdrawal development.
AU - Seo YoungJun
AU - Kwon MinSoo
AU - Choi SeungMin
AU - Lee JinKoo
AU - Park SooHyun
AU - Jung JunSub
AU - Sim YunBeom
AU - Suh HongWon
JO - Brain Research Bulletin
JF - Brain Research Bulletin
Y1 - 2009///
VL - 80
IS - 6
SP - 359
EP - 370
CY - New York; USA
PB - Elsevier
SN - 0361-9230
AD - Seo YoungJun: Advanced Therapy Products Research Division, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20093353639. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Registry Number: 302-31-8, 57-27-2, 64-31-3. Subject Subsets: Aromatic & Medicinal Plants
N2 - We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and β-endorphin. Mice were administered morphine intracerebroventricularly (i.c.v.) either once or 5 times for 5 days (once/day). A single morphine administration significantly increased the hypothalamic POMC gene and β-endorphin expression at 2 h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and β-endorphin expression. In the immunoblot and immunohistochemical study, the increase of β-endorphin was observed in the arcuate nucleus of the hypothalamus. Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIα (pCaMK-IIα), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IκB (pIκB) were not. We also found that the expressions of c-Fos, pCaMKIIα, and pCREB were co-localized with the POMC expression. Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration. Furthermore, the pretreatment of muscimol and baclofen 10 min before morphine injection robustly attenuated the withdrawal behavior induced by a single morphine administration. These results imply that the hypothalamic POMC gene and β-endorphin expression may play an important role in the development of an acute physical dependency of morphine. In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration.
KW - animal models
KW - endorphins
KW - enzymes
KW - gene expression
KW - genes
KW - hypothalamus
KW - medicinal properties
KW - morphine
KW - plant extracts
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha
KW - phosphorylated extracellular signal-regulated protein kinase1/2
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093353639&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03619230
UR - email: hwsuh@hallym.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic diversity and zoonotic potential of human rotavirus strains, 2003-2006, Hungary.
AU - Bányai, K.
AU - Bogdán, Á.
AU - Domonkos, G.
AU - Kisfali, P.
AU - Molnár, P.
AU - Tóth, A.
AU - Melegh, B.
AU - Martella, V.
AU - Gentsch, J. R.
AU - Szucs, G.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2009///
VL - 81
IS - 2
SP - 362
EP - 370
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20093042190. Publication Type: Journal Article. Language: English. Number of References: many ref. Subject Subsets: Public Health; Pig Science
N2 - Rotavirus strain surveillance is being conducted in many countries before and after introduction of newly licensed vaccines to assess the impact of the vaccines on rotavirus strains. Here we describe a strain surveillance study in the Budapest area of Hungary (2003-2006) based on RNA profile analysis, genotyping by multiplex PCR and nucleotide sequencing. Among 1,983 G-typed rotaviruses we identified G1 (22%), G2 (4.8%), G3 (3.5%), G4 (18.5%), G6 (1.1%), G8 (<0.1%, n=1), G9 (42%), and G12 (3.4%) specificities. Information on P genotype incidence was determined for a subset of samples (n=814). In addition to the globally important strains, a variety of uncommon antigen combinations were also found, for example, P[9],G3; P[14],G6; or P[14],G8. Sequence and phylogenetic analysis of the VP7, VP4, VP6, and NSP4 genes of selected strains with uncommon antigen combinations demonstrated high similarity with certain bovine, porcine, feline, equine, and lapine rotaviruses, respectively. Continued surveillance is needed to assess the role of animal rotaviruses in human diseases.
KW - DNA sequencing
KW - genetic diversity
KW - genotypes
KW - phylogenetics
KW - strains
KW - viral antigens
KW - viral diseases
KW - zoonoses
KW - Hungary
KW - Rotavirus
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - viral infections
KW - zoonotic infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Taxonomy and Evolution (ZZ380)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093042190&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - An improved approach to identify epidemiological and phylogenetic transmission pairs of source and contact tracing of hepatitis B.
AU - Veldhuijzen, I. K.
AU - Mes, T. H. M.
AU - Mostert, M. C.
AU - Niesters, H. G. M.
AU - Pas, S. D.
AU - Voermans, J.
AU - Man, R. A. de
AU - Götz, H. M.
AU - Doornum, G. J. J. van
AU - Richardus, J. H.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2009///
VL - 81
IS - 3
SP - 425
EP - 434
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Veldhuijzen, I. K.: Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, Netherlands.
N1 - Accession Number: 20093070479. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Subject Subsets: Public Health
N2 - The transmission of infectious diseases can be traced using epidemiological and molecular information. In the current study, the congruence was assessed between sequence data of the hepatitis B virus (HBV) and epidemiological information resulting from source and contact tracing of patients seen at the Municipal Public Health Service in Rotterdam between 2002 and 2005. HBV genotypes A-G were present in 62 acute and 334 chronic HBV patients. At the sequence level, the identical sequences of members of epidemiological transmission pairs and the rarity of such pairs provided strong support for correctness of the hypothesized transmission routes. The molecular support for epidemiological transmission pairs derived from source and contact tracing was further assessed by using topological constraints in parsimony analyses in agreement with epidemiological information, and by taking the presence of polymorphic sites of HBV within patients into account. This, in principle, allows mutations in epidemiological clusters. Of 22 epidemiological clusters, six could be refuted, four clusters received support from the molecular analysis, and support for the remaining twelve clusters was ambiguous. Two of the four epidemiological pairs that received molecular support had diverged (by 3 and 15 mutations). These results show that levels of divergence cannot be used simply as an indicator of the likelihood that groups of sequences constitute transmission pairs. Instead, to confirm or refute transmission pairs, it is necessary to assess the likelihood of a common origin of HBV variants in epidemiologically defined transmission groups relative to the HBV diversity in the local community.
KW - acute infections
KW - chronic infections
KW - contact tracing
KW - disease transmission
KW - genotypes
KW - hepatitis B
KW - human diseases
KW - molecular biology
KW - molecular epidemiology
KW - phylogenetics
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - severe infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093070479&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: veldhuijzeni@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Infection of mosquitoes with Plasmodium falciparum by feeding on humans and on Aotus monkeys.
AU - Collins, W. E.
AU - Jeffery, G. M.
AU - Sullivan, J. S.
AU - Nace, D.
AU - Williams, T.
AU - Galland, G. G.
AU - Williams, A.
AU - Barnwell, J. W.
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
Y1 - 2009///
VL - 81
IS - 3
SP - 529
EP - 533
CY - Northbrook; USA
PB - American Society of Tropical Medicine and Hygiene
SN - 0002-9637
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Infectious Diseases, National Center for Vector-Borne and Enteric Diseases, and Animal Resources Branch, National Centers for Preparedness and Control of Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
N1 - Accession Number: 20093267154. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Protozoology; Public Health; Tropical Diseases; Medical & Veterinary Entomology
N2 - Of 1,004 positive lots of mosquitoes fed on 229 humans infected with Plasmodium falciparum, 46.2% had 1-10 oocysts/(+)gut, 21.2% had 10-30 oocysts/(+)gut, 22.2% had 30-100 oocysts/(+)gut, and 10.4% had >100 oocysts/(+) gut. The highest levels of infection occurred between 6 and 15 days after the peak in the asexual parasite count. Of 2,281 lots of Anopheles freeborni mosquitoes fed on splenectomized Aotus monkeys infected with the Santa Lucia strain of P. falciparum, 1,191 were infected (52.2%). The highest intensity infections ranged from 2.78 oocysts per positive gut in mosquitoes fed on Aotus vociferans to 6.08 oocysts per positive gut for those fed on A. lemurinus griseimembra to 10.4 oocysts per positive gut for those fed on A. nancymaae. The pattern of infection for mosquitoes fed on splenectomized Aotus monkeys was similar to that obtained by feeding on humans, but the intensity, based on oocyst/(+)gut, was much lower.
KW - behaviour
KW - experimental infections
KW - feeding behaviour
KW - human diseases
KW - oocysts
KW - Georgia
KW - USA
KW - Anopheles freeborni
KW - Aotus
KW - Aotus vociferans
KW - Culicidae
KW - man
KW - Plasmodium falciparum
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Homo
KW - Hominidae
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - Aotus
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Southeastern States of USA
KW - Aotus nancymaae
KW - behavior
KW - feeding behavior
KW - mosquitoes
KW - United States of America
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Behaviour (Wild Animals) (YY500) (New March 2000)
KW - Pathogens, Parasites and Infectious Diseases (Wild Animals) (YY700) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093267154&site=ehost-live&scope=site
UR - http://www.ajtmh.org
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection and characterization of group C rotavirus in Buenos Aires, Argentina, 1997-2003.
AU - Castello, A. A.
AU - Argüelles, M. H.
AU - Rota, R. P.
AU - Humphrey, C. D.
AU - Olthoff, A.
AU - Gentsch, J. R.
AU - Glass, R. I.
AU - Glikmann, G.
AU - Jiang, B. M.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2009///
VL - 81
IS - 6
SP - 1109
EP - 1116
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Castello, A. A.: Division of Viral Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20093151506. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Tropical Diseases
N2 - The role of group C rotaviruses as a cause of diarrhea was examined among children <17 years of age admitted to a Hospital in a suburban area of Buenos Aires, Argentina between 1997 and 2003. A total of 1,579 fecal samples were screened for group A (RVA) and C (RVC) rotaviruses by two in-house ELISA methods at Quilmes University (UNQ-ELISA). Samples positive, doubtful and negative by RVC specific UNQ-ELISA (n=246) were examined further for RVC by another in-house ELISA (CDC-ELISA), electron microscopy, RT-PCR, nested PCR, and Southern hybridization. Sensitivity, specificity, and predictive values for each test were determined. While the sensitivity was comparable for the nested PCR and CDC-ELISA methods (82.5%), the molecular methods were slightly more specific. Poorly preserved particles were often seen in fecal samples, suggesting that degradation of RNA could be a factor influencing the performance of molecular methods. The incidence of RVC was estimated to be 3% without apparent differences among seasons. RVC infected patients had a significantly (P<0.001) higher median age (6 years vs. 1 year) than those with RVA infection. Sequence of the RVC VP7 gene from six Argentinean strains and sequences reported previously in different countries showed high nucleotide (94.4-99.9%) sequence identities, indicating a high degree of conservation for human RVC VP7 genes among strains collected on five continents over a period of 17 years. These findings indicate that RVC is a significant cause of diarrhea and it is necessary to develop simple and sensitive serological methods for its detection.
KW - children
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - diarrhoea
KW - genes
KW - genetic analysis
KW - human diseases
KW - molecular genetics techniques
KW - nucleotide sequences
KW - viral diseases
KW - Argentina
KW - man
KW - Rotavirus A
KW - Rotavirus C
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Rotavirus
KW - Reoviridae
KW - dsRNA Viruses
KW - RNA Viruses
KW - viruses
KW - Developing Countries
KW - Latin America
KW - America
KW - South America
KW - Threshold Countries
KW - diarrhea
KW - DNA sequences
KW - scouring
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093151506&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: acastello@unq.edu.ar
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Two decades of hepatitis B infections among drug users in Amsterdam: are they still a high-risk group?
AU - Houdt, R. van
AU - Berg, C. H. S. B. van den
AU - Stolte, I. G.
AU - Bruisten, S. M.
AU - Dukers, N. H. T. M.
AU - Bakker, M.
AU - Wolthers, K. C.
AU - Prins, M.
AU - Coutinho, R. A.
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2009///
VL - 81
IS - 7
SP - 1163
EP - 1169
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Houdt, R. van: Department of Infectious Diseases, Public Health Service Amsterdam, Postbus 2200, 1000 CE Amsterdam, Netherlands.
N1 - Accession Number: 20093186903. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - In general, little is known about the incidence of hepatitis B virus (HBV) among drug users, especially among non-injecting drug users. Therefore, changes in incidence, risk factors, and circulating genotypes over time were determined among drug users in Amsterdam over an 18-year period (1985-2002). Sera of 1,268 drug users, both injecting and non-injecting, were screened for anti-HBc. HBV genotypes of the anti-HBc seroconverters were determined. Poisson regression was used to test for temporal trends in incidence and to identify risk factors for seroconversion. Of the 598 participants who were anti-HBc negative at entry, 83 seroconverted for anti-HBc. The incidence of HBV declined from 5.9/100 Person Years up to 1993 to 0/100 Person Years in 2002. Of the drug users infected acutely, both injecting and non-injecting, 88% were infected with the same genotype D, serotype ayw3 strain. Multivariate analyses revealed current injecting, age, and calendar year of visit as independent risk factors. The decline in the incidence of HBV among drug users in Amsterdam is probably caused by a decline in injecting behavior. Injecting and non-injecting drug users were infected with the same strain, indicating that drug users infect one another, regardless of their risk behavior. After 2000, no injecting drug users with an acute HBV infection were reported to the Public Health Service Amsterdam and the specific genotype D strain had disappeared. These findings suggest that drug users may no longer be a high-risk group for HBV infection in Amsterdam. However, trends in drug use need to be monitored.
KW - behaviour
KW - disease incidence
KW - disease prevalence
KW - disease transmission
KW - drug users
KW - genotypes
KW - hepatitis B
KW - human diseases
KW - injecting drug users
KW - liver
KW - liver diseases
KW - molecular epidemiology
KW - risk behaviour
KW - risk factors
KW - risk groups
KW - seroconversion
KW - seroprevalence
KW - viral diseases
KW - viral hepatitis
KW - Netherlands
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - behavior
KW - drug abusers
KW - i.v. drug abusers
KW - i.v. drug users
KW - intravenous drug users
KW - risk behavior
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093186903&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: rvhoudt@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Population-based study on the seroprevalence of parvovirus B19 in Amsterdam.
AU - Rijckevorsel, G. G. C. van
AU - Sonder, G. J. B.
AU - Loeff, M. F. S. van der
AU - Hoek, J. A. R. van den
JO - Journal of Medical Virology
JF - Journal of Medical Virology
Y1 - 2009///
VL - 81
IS - 7
SP - 1305
EP - 1309
CY - New York; USA
PB - Wiley-Liss, Inc.
SN - 0146-6615
AD - Rijckevorsel, G. G. C. van: Department of Infectious Diseases, Public Health Service Amsterdam, Nieuwe Achtergracht 100, 1018 WT, Amsterdam, Netherlands.
N1 - Accession Number: 20093186921. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Public Health
N2 - A study was undertaken to estimate the seroprevalence of parvovirus B19 infection in the general adult population of Amsterdam, The Netherlands. To our knowledge this is the first study testing parvovirus B19 in a random sample of the Dutch adult population. The study was a cross-sectional survey, and the study sample was stratified by age and ethnicity, with deliberate oversampling of minority ethnic groups. Serum samples obtained from 1,323 residents in 2004 were tested for antibodies to parvovirus B19. Basic demographic data (gender, age, country of birth, and number of children) were also available. Sixty-two percent of the participants were seropositive; corrected for the oversampling the estimated prevalence in the Amsterdam adult population was 61%. No specific predictors or risk groups for seropositivity were identified. In our urban adult study population no positive correlation with increasing neither age, nor significant differences between age groups were found. These results imply that almost 40% of the adult Amsterdam population is susceptible to infection.
KW - adults
KW - antibodies
KW - disease prevalence
KW - human diseases
KW - serological surveys
KW - seroprevalence
KW - viral diseases
KW - Netherlands
KW - man
KW - Parvovirus B19
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Parvovirus
KW - Parvoviridae
KW - ssDNA viruses
KW - DNA viruses
KW - viruses
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - seroepidemiology
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093186921&site=ehost-live&scope=site
UR - http://www.interscience.wiley.com
UR - email: gvrijckevorsel@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Lactational coumestrol exposure increases ovarian apoptosis in adult rats.
AU - Moon HyunJu
AU - Seok JiHyun
AU - Kim SoonSun
AU - Rhee GyuSeek
AU - Lee RheeDa
AU - Yang JunYoung
AU - Chae SooYeong
AU - Kim SeungHee
AU - Kim JiYoung
AU - Chung JinYong
AU - Kim JongMin
AU - Chung SooYoun
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2009///
VL - 83
IS - 6
SP - 601
EP - 608
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 0340-5761
AD - Moon HyunJu: Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul, 122-704, Korea Republic.
N1 - Accession Number: 20093187238. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 479-13-0. Subject Subsets: Aromatic & Medicinal Plants; Dairy Science
N2 - This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, and 10 mg/kg COU during the lactation period and the reproductive effects of female pups were investigated in young adults. Rats were sacrificed at postnatal days (PND) 81-84. Ovarian weights were reduced significantly at 0.1 and 1.0 mg/kg COU. The reduction in the ovarian weight occurred in parallel with an increase in the apoptosis at PND 135-140. A marked dose-dependent increase in the expressions of active caspase-3 and -7 was observed in ovarian granulosa cells. Immunostaining for active caspase-3 and the TUNEL staining of apoptotic cells were also increased in ovaries exposed to COU in a dose-dependent manner. These results suggest new sights into the effect of lactational exposure to COU on the female reproductive health.
KW - animal models
KW - apoptosis
KW - coumoestrol
KW - granulosa cells
KW - in vitro
KW - lactation
KW - ovaries
KW - plant extracts
KW - reproduction
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - caspase-3
KW - caspase-7
KW - coumestrol
KW - Non-food/Non-feed Plant Products (SS200)
KW - Human Reproduction and Development (VV060)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093187238&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/g50wmw188nh8457n/fulltext.html
UR - email: mhj1612@kfda.go.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effectiveness of an opting-out strategy for HIV testing: evaluation of 4 years of standard HIV testing in a STI clinic.
AU - Dukers-Muijrers, N. H. T. M.
AU - Niekamp, A. M.
AU - Vergoossen, M. M. H.
AU - Hoebe, C. J. P. A.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2009///
VL - 85
IS - 3
SP - 226
EP - 230
CY - London; UK
PB - BMJ Publishing Group
SN - 1368-4973
AD - Dukers-Muijrers, N. H. T. M.: Department of Infectious Diseases, South Limburg Public Health Service, PO Box 2022, 6160 HA Geleen, Netherlands.
N1 - Accession Number: 20093164317. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Objectives: A high proportion of individuals infected with HIV are unaware of the infection. They miss the opportunity for timely treatment. Our sexually transmitted infection (STI) clinic (South Limburg, The Netherlands) recognised the need to increase test rates and from 2004 routinely includes a HIV test, unless the client refuses, in each consultation. We evaluated the effectiveness of this opting-out approach for HIV testing. Methods: We used anonymised data from our STI clinic from 2003-2007 to assess trends in HIV testing and (reasons for) test refusal using multivariate analyses and interview. Laboratory registry data from the area that is served by the clinic were evaluated as well. Results: In South Limburg the number of HIV tests increased, which was mostly due to increasing STI clinic requests and antenatal screening. Of STI clinic attendees, 84% (1616/1920) were tested in 2003 and this proportion increased to 96% (3699/3836) in 2007. However, 88% (n=57/65) of men who have sex with men and 44% (191/424) of heterosexuals who refused HIV testing after 2004 were linked to higher STI/HIV risk. Our clinic now uses these findings to develop more effective and tailored HIV/STI counselling in order to further optimise HIV testing practice. Conclusions: Standard testing on HIV in a STI clinic is feasible and effective in increasing awareness of one's HIV status. It should be an essential part of STI screening in STI clinics and should be considered in other healthcare settings for specific risk groups.
KW - diagnosis
KW - heterosexuality
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - men who have sex with men
KW - screening
KW - sexual behaviour
KW - sexually transmitted diseases
KW - trends
KW - viral diseases
KW - Netherlands
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - heterosexuals
KW - human immunodeficiency virus infections
KW - screening tests
KW - sexual behavior
KW - sexual practices
KW - sexuality
KW - STDs
KW - venereal diseases
KW - viral infections
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093164317&site=ehost-live&scope=site
UR - http://sti.bmj.com/cgi/content/abstract/85/3/226
UR - email: nicole.dukers@ggdzl.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Availability of medical countermeasures for bioterrorism events: US legal and regulatory options.
AU - Maher, C.
AU - Lushniak, B. D.
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
Y1 - 2009///
VL - 85
IS - 6
SP - 669
EP - 671
CY - Basingstoke; UK
PB - Nature Publishing Group
SN - 0009-9236
AD - Maher, C.: Office of Counterterrorism and Emerging Threats, US Food and Drug Administration, US Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20093170909. Publication Type: Journal Article. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Plans for mass distribution of medical countermeasures raise challenging problems, including legal and regulatory issues. Many in the distribution chain have expressed concerns over the potential for liability when countermeasures are distributed in accordance with large-scale response plans. This is of particular concern if the medical countermeasure involved has not been approved, cleared, or licensed by the US Food and Drug Administration (FDA). This article discusses legal and regulatory options for countermeasure distribution that address liability concerns and access to unapproved countermeasures during an emergency.
KW - biological warfare
KW - emergencies
KW - human diseases
KW - law
KW - legislation
KW - medical services
KW - regulations
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - legal aspects
KW - legal principles
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Health Services (UU350)
KW - Conflict (UU495) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093170909&site=ehost-live&scope=site
UR - http://www.nature.com/clpt/journal/v85/n6/full/clpt200955a.html
UR - email: carmen.maher@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The animal rule and emerging infections: the role of clinical pharmacology in determining an effective dose.
AU - Bergman, K. L.
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
Y1 - 2009///
VL - 86
IS - 3
SP - 328
EP - 331
CY - Basingstoke; UK
PB - Nature Publishing Group
SN - 0009-9236
AD - Bergman, K. L.: Center for Drug Evaluation and Research, Office of Translational Sciences, Office of Clinical Pharmacology, US food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20093274316. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
KW - antiinfective agents
KW - dosage
KW - drug therapy
KW - efficacy
KW - emerging infectious diseases
KW - human diseases
KW - infectious diseases
KW - pharmacodynamics
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antimicrobials
KW - chemotherapy
KW - communicable diseases
KW - drug action
KW - emerging diseases
KW - emerging infections
KW - mechanism of drug action
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093274316&site=ehost-live&scope=site
UR - http://www.nature.com/clpt/journal/v86/n3/abs/clpt2009106a.html
UR - email: kimberly.bergman@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Nutrition labeling: rapid determination of total trans fats by using internal reflection infrared spectroscopy and a second derivative procedure.
AU - Mossoba, M. M.
AU - Seiler, A.
AU - Kramer, J. K. G.
AU - Milosevic, V.
AU - Milosevic, M.
AU - Azizian, H.
AU - Steinhart, H.
JO - Journal of the American Oil Chemists' Society
JF - Journal of the American Oil Chemists' Society
Y1 - 2009///
VL - 86
IS - 11
SP - 1037
EP - 1045
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 0003-021X
AD - Mossoba, M. M.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Mail Stop HFS-717, Room BE-012, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093305278. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - In 2006, the US FDA mandated the declaration of the total trans fat content on the Nutrition Fact label of foods including dietary supplements when a product contained 0.5 or more grams of trans fatty acid per serving; the minimum corresponding trans fat content is estimated to be approximately 2% of total fat. The FDA definition is based on chemical structure and includes only fatty acids with one or more isolated double bonds in the trans configuration. Several issues negatively impacted the sensitivity of the current official infrared (IR) methods, thus limited the quantitation of trans fat to 5% of total fat. To improve sensitivity and accuracy and to meet the labeling requirement, a new internal reflection IR procedure called negative second derivative is described and evaluated for the quantitation of total trans fat in the present study. The enhanced spectral features of a second derivative resolved issues that traditionally limited the sensitivity of the IR methodology. Calibration standard mixtures starting at approximately 0.5% trielaidin in the total fat (tripalmitin or triarachidin) were successfully generated and used to determine the trans fat levels for unknown test samples with trans content as low as approximately 1% of total fat. Quantitative IR data were compared to those obtained by gas chromatography and were found to be in good agreement.
KW - analytical methods
KW - fat
KW - food composition
KW - infrared spectroscopy
KW - nutrition labeling
KW - quantitative analysis
KW - quantitative techniques
KW - analytical techniques
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093305278&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/m380516344768527/?p=c27d4b51552741818c2e47a7baf81587&pi=1
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya.
AU - Mansoer, J.
AU - Scheele, S.
AU - Floyd, K.
AU - Dye, C.
AU - Sitienei, J.
AU - Williams, B.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2009///
VL - 87
IS - 3
SP - 186
EP - 192
CY - Geneva; Switzerland
PB - World Health Organization
SN - 0042-9686
AD - Mansoer, J.: US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya.
N1 - Accession Number: 20093117532. Publication Type: Journal Article. Language: English. Language of Summary: French; Spanish; Arabic. Number of References: 32 ref. Subject Subsets: Tropical Diseases; Rural Development
N2 - Objective: To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent. Methods: We estimated the smear-positive tuberculosis CDR in HIV-negative and HIV-positive adults, and in all adults in Kenya. Data on time trends in tuberculosis case notification rates and on HIV infection prevalence in adults and in tuberculosis patients were used, along with data on tuberculosis control programme performance. Findings: In 2006, the estimated smear-positive tuberculosis CDR in HIV-negative adults was 79% (95% confidence interval, CI: 64-94) and in HIV-positive adults, 57% (95% CI: 26-88), giving a weighted mean of 68% (95% CI: 49-87). The separate estimate for all smear-positive tuberculosis cases was 72% (95% CI: 53-91), giving an overall average for the three estimates of 70% (95% CI: 58-82). As the tuberculosis CDR in 1996 was 57% (95% CI: 47-67), the estimated increase by 2006 was 13 percentage points (95% CI: 6-20), or 23%. This increase was accompanied by a more than doubling of the resources devoted to tuberculosis control in Kenya, including facilities and staff. Conclusion: Using three approaches to estimate the tuberculosis CDR in a country where HIV infection is prevalent, we showed that expansion of the tuberculosis control programme in Kenya led to an increase of 23% in the CDR between 1996 and 2006. While the methods developed here can be applied in other countries with a high prevalence of HIV infection, they rely on precise data on trends in such prevalence in the general population and among tuberculosis patients.
KW - control
KW - control programmes
KW - estimation
KW - HIV infections
KW - human diseases
KW - human immunodeficiency viruses
KW - infections
KW - methodology
KW - patients
KW - sputum
KW - techniques
KW - tuberculosis
KW - Kenya
KW - man
KW - Mycobacterium tuberculosis
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Bacteria
KW - prokaryotes
KW - ACP Countries
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - East Africa
KW - Africa South of Sahara
KW - bacterium
KW - control programs
KW - human immunodeficiency virus infections
KW - methods
KW - notifications
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093117532&site=ehost-live&scope=site
UR - http://www.who.int/bulletin
UR - email: williamsbg@who.int
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims.
AU - Kim JiYeon
AU - Kwon Oran
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2009///
VL - 89
IS - 1
SP - 257
EP - 264
CY - Bethesda; USA
PB - American Society for Clinical Nutrition
SN - 0002-9165
AD - Kim JiYeon: Division of Nutrition and Functional Food Standards, Korea Food and Drug Administration, Seoul, Korea Republic.
N1 - Accession Number: 20093101651. Publication Type: Journal Article. Language: English. Number of References: 55 ref. Subject Subsets: Public Health; Horticultural Science; Human Nutrition
N2 - Background: Numerous animal and in vitro studies provided evidence for a relation between garlic intake and cancer risk reduction. Several studies also reported an inverse association in humans. However, no claims have been made about garlic intake and cancer risk reduction with respect to food labeling. Objective: The objective of this study was to evaluate the scientific evidence for garlic intake with respect to the risk of different types of cancer using the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. Design: Literature searches were conducted by using the Medline and EMBASE databases for the period 1955-2007 with search terms Allium sativum, vegetables, diet, and nutrition in combination with cancer, neoplasm, and individual cancers. The search was limited to human studies published in English and Korean. Results: With the use of the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims, 19 human studies were identified and reviewed to evaluate the strength of the evidence that supports a relation between garlic intake and reduced risk of different cancers with respect to food labeling. Conclusions: There was no credible evidence to support a relation between garlic intake and a reduced risk of gastric, breast, lung, or endometrial cancer. Very limited evidence supported a relation between garlic consumption and reduced risk of colon, prostate, esophageal, larynx, oral, ovary, or renal cell cancers.
KW - colon
KW - databases
KW - evaluation
KW - food
KW - garlic
KW - health
KW - human diseases
KW - in vitro
KW - kidneys
KW - labelling
KW - lungs
KW - neoplasms
KW - nutrition
KW - ovaries
KW - prostate
KW - research
KW - stomach
KW - vegetables
KW - Allium
KW - Allium sativum
KW - man
KW - Alliaceae
KW - Liliaceae
KW - Liliales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Allium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - cancers
KW - data banks
KW - labeling
KW - labels
KW - risks
KW - studies
KW - vegetable crops
KW - Information and Documentation (CC300)
KW - Food Science and Food Products (Human) (QQ000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Crop Produce (QQ050)
KW - Human Nutrition (General) (VV100)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093101651&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: orank@ewha.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots.
AU - Yong, L. C.
AU - Petersen, M. R.
AU - Sigurdson, A. J.
AU - Sampson, L. A.
AU - Ward, E. M.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2009///
VL - 90
IS - 5
SP - 1402
EP - 1410
CY - Bethesda; USA
PB - American Society for Nutrition
SN - 0002-9165
AD - Yong, L. C.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093356503. Publication Type: Journal Article. Language: English. Number of References: 40 ref. Registry Number: 50-81-7, 7235-40-7, 9007-49-2, 502-65-8, 1406-18-4. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science; Human Nutrition
N2 - Background: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. Objective: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. Design: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. Results: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, β-carotene, β-cryptoxanthin, and lutein-zeaxanthin from food (P<0.05). Translocation frequency was not associated with the intake of vitamin E, α-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios (95% CI) for ≥median compared with <median servings per week of high-vitamin C fruit and vegetables, citrus fruit, and green leafy vegetables were 0.61 (0.43, 0.86), 0.64 (0.46, 0.89), and 0.59 (0.43, 0.81), respectively. The strongest inverse association was observed for ≥median compared with <median combined intakes of vitamins C and E, β-carotene, β-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55). Conclusion: High combined intakes of vitamins C and E, β-carotene, β-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons.
KW - antioxidants
KW - ascorbic acid
KW - beta-carotene
KW - carotenes
KW - carotenoids
KW - citrus fruits
KW - diets
KW - DNA
KW - DNA modification
KW - estimation
KW - fluorescence
KW - food
KW - food intake
KW - fruits
KW - intake
KW - leafy vegetables
KW - lycopene
KW - nutrition
KW - phytochemicals
KW - questionnaires
KW - ratios
KW - supplements
KW - techniques
KW - terpenoids
KW - vegetables
KW - vitamin E
KW - vitamins
KW - Citrus
KW - man
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - deoxyribonucleic acid
KW - DNA damage
KW - green vegetables
KW - Rutales
KW - terpenes
KW - tetraterpenoids
KW - vegetable crops
KW - vitamin C
KW - Crop Produce (QQ050)
KW - Human Nutrition (General) (VV100)
KW - Food Science and Food Products (Human) (QQ000)
KW - Diet Studies (VV110)
KW - Plant Composition (FF040)
KW - Techniques and Methodology (ZZ900)
KW - Horticultural Crops (FF003) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093356503&site=ehost-live&scope=site
UR - http://www.ajcn.org/
UR - email: lay7@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incomplete recoveries of fumonisins present in naturally contaminated corn foods from an immunoaffinity column.
AU - Oh KeumSoon
AU - Scott, P. M.
AU - Chung SooHyun
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 2
SP - 496
EP - 501
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Oh KeumSoon: Korea Food and Drug Administration, Department of Food Safety Evaluation, Seoul 122-704, Korea Republic.
N1 - Accession Number: 20093131581. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Subject Subsets: Medical & Veterinary Mycology; Postharvest Research; Maize
N2 - Following previous observations of apparent instability of fumonisin B1 in corn starch and corn meal, immunoaffinity column (IAC) cleanup, of the type used in the analysis of commercial starch-containing corn foods for fumonisins, was investigated. Foods analyzed for naturally occurring fumonisins B1, B2, and B3 included corn flour (3 different products), corn meal, and corn flakes. In 2 series of experiments, fractions were eluted by gravity or vacuum from narrow- or wide-bore Fumonitest IACs either with 2×2 mL methanol, followed by 2 mL methanol-water (8+2, v/v), or with 2 mL methanol, then 2 mL methanol-water (8+2, v/v). The ratio (%) of fumonisin B1 concentration in the first methanol eluate to the total concentration measured from all eluates in most cases varied from 25-70%. Incomplete recoveries were also observed for fumonisins 62 and 63. It is concluded that there can be a major underestimation of naturally occurring fumonisins in methods using only methanol elution for IAC cleanup, as in AOAC INTERNATIONAL Official Method 2001.04 (accuracy of these methods had been determined only by spiking the food with fumonisins). Elution with 2×2 mL methanol-water (8+2, v/v) was chosen as a practical procedure; means of 81-98% of the total fumonisin B1 concentration were found in the first eluate, except for corn flakes and 2 experiments with corn meal.
KW - corn flour
KW - food contamination
KW - fumonisins
KW - maize
KW - maize meal
KW - methodology
KW - recovery
KW - Zea mays
KW - Zea
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - corn
KW - corn flakes
KW - cornflour
KW - food contaminants
KW - maize flour
KW - methods
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093131581&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: peter_scott@hc-sc.gc.ca
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Determination of bromine in regulated foods with a field-portable X-ray fluorescence analyzer.
AU - Anderson, D. L.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 2
SP - 502
EP - 510
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Anderson, D. L.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Chemical Contaminants Branch, HFS-716, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093131582. Publication Type: Journal Article. Language: English. Number of References: 22 ref. Registry Number: 7726-95-6. Subject Subsets: Wheat, Barley & Triticale Abstracts; Human Nutrition
N2 - A field-portable X-ray fluorescence analyzer, factory-calibrated for soil analysis, was used to measure bromine (Br) mass fractions in reference materials, flour, bakery products, malted barley, selected U.S. Food and Drug Administration Total Diet Study foods, and other food products. By using a calibration based on instrumental neutron activation analysis results for Br in reference materials, accurate quantitative results, confirmed by z-scores, could be obtained for mass fractions of about 2-55 mg/kg. These results confirmed accuracy of results (with larger uncertainties) obtained by applying a simple correction factor to the analyzer's output value. Results showed that very short analysis times (<2 min) would be needed to screen foods for Br content at regulatory levels for brominated and enriched brominated flour (24 mg/kg Br) and whole wheat flour and bakery products (36 mg/kg Br). Feasibility for determination of Br in malted barley at the regulatory level (75 mg/kg Br) was demonstrated, but quantitative results at that level could not be assured because no reference material with a suitable mass fraction was available. Br mass fractions for all foods tested were well below regulatory levels.
KW - analytical methods
KW - bakery products
KW - bromine
KW - carcinogens
KW - flours
KW - instruments
KW - malt
KW - analytical techniques
KW - baked goods
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093131582&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: david.anderson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Multiresidue analysis of 102 organophosphorus pesticides in produce at parts-per-billion levels using a modified QuEChERS method and gas chromatography with pulsed flame photometric detection.
AU - Schenck, F.
AU - Wong, J.
AU - Lu, C. S.
AU - Li, J.
AU - Holcomb, J. R.
AU - Mitchell, L. M.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 2
SP - 561
EP - 573
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Schenck, F.: U.S. Food and Drug Administration, Office of Regulatory Affairs, 60 Eighth St NE, Atlanta, GA 30309, USA.
N1 - Accession Number: 20093131589. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Human Nutrition; Postharvest Research
N2 - A multiresidue method for the analysis of organophosphorus pesticides in fresh produce at levels down to 1.0 µg/kg (ppb) has been developed using a modification of the QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure. The procedure entails extraction of pesticides from the sample with acetonitrile, salting-out with magnesium sulfate (MgSO4) and sodium chloride, and cleanup of the resulting extracts with dispersive solid-phase extraction using primary-secondary amine, graphitized carbon black, and MgSO4. Fortification studies were performed for 102 organophosphorus pesticides at 1.0, 10, and 100 ppb in 4 different pesticide-free commodities (grape, orange, spinach, and tomato). Recoveries ranged from 63-125%, with >80% being achieved for most of the pesticides tested in each commodity. The procedure was applied to the analysis of 400 produce samples collected from a cohort of children that participated in the Children's Pesticide Exposure Study and the Longitudinal Dietary Pesticide Exposure Study in which selected 24 h duplicate food items were collected throughout a 12-month period. Residues of 15 of the 102 pesticides were detected at levels ranging from <1 to 526 ppb.
KW - analytical methods
KW - extraction
KW - extracts
KW - food contamination
KW - grapes
KW - methodology
KW - oranges
KW - organophosphorus pesticides
KW - pesticide residues
KW - spinach
KW - tomatoes
KW - Citrus
KW - Solanum lycopersicum
KW - Spinacia oleracea
KW - Vitidaceae
KW - Vitis
KW - Rutaceae
KW - Sapindales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Solanum
KW - Solanaceae
KW - Solanales
KW - Spinacia
KW - Chenopodiaceae
KW - Caryophyllales
KW - Vitidaceae
KW - Rhamnales
KW - analytical techniques
KW - food contaminants
KW - Lycopersicon esculentum
KW - methods
KW - Rutales
KW - Vitaceae
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093131589&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: fschenck@live.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of a revised U.S. Food and Drug Administration method for the detection and isolation of Enterobacter sakazakii in powdered infant formula: precollaborative study.
AU - Chen, Y. I.
AU - Hammack, T. S.
AU - Song, K. Y.
AU - Lampel, K. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 3
SP - 862
EP - 872
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Chen, Y. I.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
N1 - Accession Number: 20093181088. Publication Type: Journal Article. Language: English. Number of References: 11 ref. Registry Number: 9000-71-9. Subject Subsets: Soyabeans; Human Nutrition; Dairy Science
N2 - A revised U.S. Food and Drug Administration (FDA) method for the detection and isolation of Enterobacter sakazakii in powdered infant formula was developed based on real-time PCR technology complemented by culture isolation on chromogenic agars. A validation study was conducted to compare the revised FDA method to the reference FDA method. Casein and soy powdered infant formula inoculated with morphologically typical and atypical strains of E. sakazakii were analyzed. Valid results were obtained from 360 test portions and controls and showed that the revised FDA method is significantly better (P<0.05) than the reference FDA method for the detection of typical E. sakazakii strains and the two methods are equivalent for the detection of atypical E. sakazakii strains.
KW - casein
KW - detection
KW - food contamination
KW - infant formulae
KW - methodology
KW - polymerase chain reaction
KW - soya milk
KW - strains
KW - USA
KW - Enterobacter sakazakii
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - methods
KW - PCR
KW - soy milk
KW - soyabean milk
KW - United States of America
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093181088&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: keith.lampel@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trans fat labeling and levels in U.S. foods: assessment of gas chromatographic and infrared spectroscopic techniques for regulatory compliance.
AU - Mossoba, M. M.
AU - Moss, J.
AU - Kramer, J. K. G.
A2 - Gilani, G. S.
A2 - Ratnayake, W. M. N.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 5
SP - 1284
EP - 1300
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Mossoba, M. M.: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD 20740, USA.
N1 - Accession Number: 20093349894. Publication Type: Journal Article; Conference paper. Language: English. Number of References: 97 ref. Subject Subsets: Human Nutrition
N2 - Trans fatty acids are found in a variety of foods like dairy and meat products, but the major dietary sources are products that contain commercially hydrogenated fats. There has been a renewed need for accurate analytical methods for the quantitation of total trans fat since mandatory requirements to declare the amount of trans fat present in food products and dietary supplements were issued in many countries. Official capillary GC and IR methodologies are the two most common validated methods used to identify and quantify trans fatty acids for regulatory compliance. The present article provides a comprehensive discussion of the GC and IR techniques, including the latest attenuated total reflection (ATR)-FTIR methodology called the negative second derivative ATR-FTIR procedure, which is currently being validated in an international collaborative study. The identification and quantitation of trans fatty acid isomers by GC is reviewed and an alternative GC method is proposed using two temperature programs and combining their results; this proposed method deals more effectively with the resolution of large numbers of geometric and positional monoene, diene, and triene fatty acid isomers present in ruminant fats. In addition, the different methylation procedures that affect quantitative conversion to fatty acid methyl esters are reviewed. There is also a lack of commercial chromatographic standards for many trans fatty acid isomers. This review points to potential sources of interferences in the FTIR determination that may lead to inaccurate results, particularly at low trans levels. The presence of high levels of saturated fats may lead to interferences in the FTIR spectra observed for trans triacylglycerols (TAGs). TAGs require no derivatization, but have to be melted prior to IR measurement. While GC is currently the method of choice, ATR-FTIR spectroscopy is a viable, rapid alternative, and a complementary method to GC for a more rapid determination of total trans fats for food labeling purposes.
KW - analytical methods
KW - fatty acids
KW - food composition
KW - food products
KW - gas chromatography
KW - infrared spectroscopy
KW - labelling
KW - nutrition labeling
KW - regulations
KW - reviews
KW - saturated fats
KW - trans fatty acids
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - analytical techniques
KW - labeling
KW - labels
KW - rules
KW - United States of America
KW - Laws and Regulations (DD500)
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093349894&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: magdi.mossoba@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of a hydrolytic procedure and spectrometric methods in the structure elucidation of a thiocarbonyl analogue of sildenafil detected as an adulterant in an over-the-counter herbal aphrodisiac.
AU - Reepmeyer, J. C.
AU - d'Avignon, D. A.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2009///
VL - 92
IS - 5
SP - 1336
EP - 1342
CY - Gaithersburg; USA
PB - AOAC International
SN - 1060-3271
AD - Reepmeyer, J. C.: U.S. Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA.
N1 - Accession Number: 20093349853. Publication Type: Journal Article. Language: English. Number of References: 16 ref. Subject Subsets: Aromatic & Medicinal Plants; Horticultural Science; Human Nutrition
N2 - A sildenafil-related compound was detected in an herbal dietary supplement marketed as an aphrodisiac. The compound was identified as an analogue of sildenafil in which the carbonyl group in the pyrimidine ring of sildenafil was substituted with a thiocarbonyl group, and the methyl group on the piperazine ring was substituted with a hydroxyethyl group. Based on this structure, the compound was named thiohydroxyhomosildenafil. The structure of the compound was established using HPLC/MS, UV spectrometry, electrospray ionization-MS/MS, NMR spectrometry, and a hydrolytic process. One key product of hydrolysis was 1-(2-hydroxyethyl)-piperazine; the identification of this product defined the amine portion of the compound. Another key product of hydrolysis was hydroxyhomosildenafil, generated by hydrolysis of the thiocarbonyl group to a carbonyl group (C=S -> C=O). Hydroxyhomosildenafil was detected as a minor component in the dietary supplement.
KW - adulterants
KW - adulteration
KW - analogues
KW - detection
KW - food supplements
KW - herbal drugs
KW - HPLC
KW - mass spectrometry
KW - methodology
KW - structure
KW - analogs
KW - herbal medicines
KW - high performance liquid chromatography
KW - methods
KW - sildenafil
KW - Horticultural Crops (FF003) (New March 2000)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093349853&site=ehost-live&scope=site
UR - http://www.aoac.org
UR - email: reepmeyer@gmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse.
AU - Collins, W. E.
AU - Sullivan, J. S.
AU - Nace, D.
AU - Williams, T.
AU - Williams, A.
AU - Barnwell, J. W.
JO - Journal of Parasitology
JF - Journal of Parasitology
Y1 - 2009///
VL - 95
IS - 2
SP - 349
EP - 352
CY - Lawrence; USA
PB - American Society of Parasitologists
SN - 0022-3395
AD - Collins, W. E.: Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, and Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, GA 30341, USA.
N1 - Accession Number: 20093345923. Publication Type: Journal Article. Language: English. Registry Number: 50-63-8, 54-05-7, 132-73-0. Subject Subsets: Protozoology; Medical & Veterinary Entomology
N2 - Forty-four splenectomized Aotus nancymaae monkeys were infected with 6 different strains of Plasmodium cynomolgi, 11 via trophozoites and 33 via sporozoites. Sporozoites from Anopheles dirus, Anopheles freeborni, Anopheles gambiae, Anopheles maculatus, and Anopheles stephensi resulted in prepatent periods ranging from 9 to 39 days (median of 15 days). Importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the Rossan strain following treatment with chloroquine.
KW - animal models
KW - antimalarial properties
KW - chloroquine
KW - disease transmission
KW - drug therapy
KW - laboratory animals
KW - malaria
KW - relapse
KW - sporozoites
KW - trophozoites
KW - Anopheles freeborni
KW - Anopheles gambiae
KW - Anopheles maculatus
KW - Anopheles stephensi
KW - Aotus
KW - Plasmodium cynomolgi
KW - Anopheles
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Cebidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - anti-malarial properties
KW - Aotus nancymae
KW - chemotherapy
KW - recurrence of disease
KW - relapses
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Animal and in-vitro Models for Pharmaceuticals (VV450) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093345923&site=ehost-live&scope=site
UR - http://www.journalofparasitology.org/perlserv/?request=get-abstract&doi=10.1645%2FGE-1797.1
UR - email: wec1@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Justice system involvement into young adulthood: comparison of adolescent girls in the public mental health system and in the general population.
AU - Davis, M.
AU - Fisher, W. H.
AU - Gershenson, B.
AU - Grudzinskas, A. J.
AU - Banks, S. M.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2009///
VL - 99
IS - 2
SP - 234
EP - 236
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Davis, M.: Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, USA.
N1 - Accession Number: 20093244639. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - We compared arrest onset and frequency and types of charges between a statewide cohort of adolescent girls in the public mental health system and girls of the same age in the general population to investigate important differences that could have policy or intervention implications. Girls in the public mental health system were arrested at earlier ages more frequently and were charged with more serious offenses than were girls in the general population. Our results strongly argue for cooperation between the public mental health and justice systems to provide mental health and offender rehabilitation in their shared population.
KW - adolescents
KW - behaviour
KW - children
KW - delinquent behaviour
KW - girls
KW - law
KW - legislation
KW - mental health
KW - public health
KW - young adults
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - behavior
KW - delinquency
KW - delinquent behavior
KW - legal aspects
KW - legal principles
KW - teenagers
KW - Laws and Regulations (DD500)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093244639&site=ehost-live&scope=site
UR - http://www.ajph.org/
UR - email: maryann.davis@umassmed.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Measles outbreak in South Africa, 2003-2005.
AU - McMorrow, M. L.
AU - Gabremedhin, G.
AU - Heever, J. van den
AU - Kezaala, R.
AU - Harris, B.
AU - Nandy, R.
AU - Strebel, P.
AU - Jack, A.
AU - Cairns, K. L.
JO - SAMJ - South African Medical Journal
JF - SAMJ - South African Medical Journal
Y1 - 2009///
VL - 99
IS - 5
SP - 314
EP - 319
CY - Pretoria; South Africa
PB - SAMA Health and Medical Publishing Group
SN - 0256-9574
AD - McMorrow, M. L.: Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector- Borne, and Enteric Diseases, Centers for Disease Control and Prevention and United States Public Health Service, Atlanta, Georgia, USA.
N1 - Accession Number: 20093160296. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Subject Subsets: Tropical Diseases
N2 - Objectives: Measles was virtually eliminated in South Africa following control activities in 1996-7. However, from July 2003 - November 2005, 1676 laboratory-confirmed measles cases were reported in South Africa. We investigated the outbreak's cause and the role of HIV. Design: We traced laboratory-confirmed case-patients residing in Johannesburg Metropolitan (JBM) and O.R. Tambo districts. We interviewed laboratory- or epidemiologically-confirmed case-patients or their caregivers to determine vaccination status and, in JBM, HIV status. We calculated vaccine effectiveness using the screening method. Setting: Household survey in JBM and O.R. Tambo districts Outcome measures: Vaccine effectiveness, case-fatality rate, and hospitalizations. Results: In JBM, 109 case-patients were investigated. Of the 57 case-patients eligible for immunization, 27 (47.4%) were vaccinated. Fourteen (12.8%) case-patients were HIV-infected, 46 (42.2%) were HIV-uninfected, and 49 (45.0%) had unknown HIV status. Among children aged 12-59 months, vaccine effectiveness was 85% (95% CI: 63, 94) for all children, 63% for HIV-infected, 75% for HIV-uninfected and 96% for children with unknown HIV status*. In O.R. Tambo, 157 case-patients were investigated. Among the 138 case-patients eligible for immunization, 41 (29.7%) were vaccinated. Vaccine effectiveness was 89% (95% CI: 77, 95). Conclusions: The outbreak's primary cause was failure to vaccinate enough of the population to prevent endemic measles transmission. Although vaccine effectiveness may have been lower in HIV-infected than uninfected children, population vaccine effectiveness remained high.
KW - children
KW - epidemiology
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - immunization
KW - measles
KW - outbreaks
KW - vaccination
KW - South Africa
KW - man
KW - Measles virus
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Anglophone Africa
KW - Africa
KW - Commonwealth of Nations
KW - Developing Countries
KW - Southern Africa
KW - Africa South of Sahara
KW - Threshold Countries
KW - human immunodeficiency virus infections
KW - immune sensitization
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093160296&site=ehost-live&scope=site
UR - http://www.samj.org.za/index.php/samj/article/view/2750/2349
UR - email: MMcmorrow@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Protecting home health care workers: a challenge to pandemic influenza preparedness planning.
AU - Baron, S.
AU - McPhaul, K.
AU - Phillips, S.
AU - Gershon, R.
AU - Lipscomb, J.
A2 - Tarantola, D.
T3 - Special Issue: Influenza preparedness and response.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2009///
VL - 99
SP - S301
EP - S307
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Baron, S.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093337394. Publication Type: Journal Article. Note: Special Issue: Influenza preparedness and response. Language: English. Number of References: 44 ref. Subject Subsets: Public Health
N2 - The home health care sector is a critical element in a pandemic influenza emergency response. Roughly 85% of the 1.5 million workers delivering in-home care to 7.6 million clients are low-wage paraprofessionals, mostly women, and disproportionately members of racial and ethnic minorities. Home health care workers' ability and willingness to respond during a pandemic depends on appropriate communication, training, and adequate protections, including influenza vaccination and respiratory protection. Preparedness planning should also include support for child care and transportation and help home health care workers protect their income and access to health care. We summarize findings from a national stakeholder meeting, which highlighted the need to integrate home health care employers, workers, community advocates, and labor unions into the planning process.
KW - child care
KW - children
KW - health care
KW - health care workers
KW - home care
KW - human diseases
KW - influenza
KW - Influenza viruses
KW - planning
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - flu
KW - Health Services (UU350)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093337394&site=ehost-live&scope=site
UR - http://www.ajph.org/
UR - email: SBaron@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pandemic influenza and farmworkers: the effects of employment, social, and economic factors.
AU - Steege, A. L.
AU - Baron, S.
AU - Davis, S.
AU - Torres-Kilgore, J.
AU - Sweeney, M. H.
A2 - Tarantola, D.
T3 - Special Issue: Influenza preparedness and response.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2009///
VL - 99
SP - S308
EP - S315
CY - Washington; USA
PB - American Public Health Association
SN - 0090-0036
AD - Steege, A. L.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (NIOSH/CDC), 4676 Columbia Pkwy MS R18, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093337395. Publication Type: Journal Article. Note: Special Issue: Influenza preparedness and response. Language: English. Number of References: 56 ref. Subject Subsets: Public Health
N2 - Employment, social, and economic factors have the potential to affect the magnitude of an influenza pandemic among farmworkers. Prevention efforts targeted toward livestock farmworkers, including increased access to seasonal influenza vaccine, risk reduction training, various forms of personal protection, and workplace sanitation, are needed. Crop and livestock farmworkers are at increased risk of exposure to influenza A viruses because of limited resources, substandard housing, immigration status, communication and cultural barriers, and discrimination. Recommendations were gathered from migrant clinicians, farmworker advocates, state and federal government agencies, industry stakeholders, and researchers to overcome these barriers, including surveillance of livestock farmworkers, inclusion of farmworker service organizations in planning efforts, and separation of immigration enforcement from emergency assistance.
KW - employment
KW - farm workers
KW - human diseases
KW - influenza
KW - Influenza viruses
KW - livestock farming
KW - occupational hazards
KW - social barriers
KW - socioeconomic status
KW - Ohio
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - East North Central States of USA
KW - flu
KW - jobs
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093337395&site=ehost-live&scope=site
UR - http://www.ajph.org/
UR - email: asteege@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis.
AU - Eijsden, M. van
AU - Hornstra, G.
AU - Wal, M. F. van der
AU - Bonsel, G. J.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 2009///
VL - 101
IS - 12
SP - 1761
EP - 1768
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0007-1145
AD - Eijsden, M. van: Department of Epidemiology, Documentation and Health Promotion, Public Health Service of Amsterdam, Amsterdam, Netherlands.
N1 - Accession Number: 20093204537. Publication Type: Journal Article. Language: English. Number of References: 45 ref. Registry Number: 506-32-1. Subject Subsets: Tropical Diseases; Human Nutrition; Rural Development
N2 - Ethnicity-related differences in maternal n-3 and n-6 fatty acid status may be relevant to ethnic disparities in birth outcomes observed worldwide. The present study explored differences in early pregnancy n-3 and n-6 fatty acid composition of maternal plasma phospholipids between Dutch and ethnic minority pregnant women in Amsterdam, the Netherlands, with a focus on the major functional fatty acids EPA (20:5n-3), DHA (22:6n-3), dihomo-γ-linolenic acid (DGLA; 20:3n-6) and arachidonic acid (AA; 20:4n-6). Data were derived from the Amsterdam Born Children and their Development (ABCD) cohort (inclusion January 2003 to March 2004). Compared with Dutch women (n 2443), Surinamese (n 286), Antillean (n 63), Turkish (n 167) and Moroccan (n 241) women had generally lower proportions of n-3 fatty acids (expressed as percentage of total fatty acids) but higher proportions of n-6 fatty acids (general linear model; P<0.001). Ghanaian women (n 54) had higher proportions of EPA and DHA, but generally lower proportions of n-6 fatty acids (P<0.001). Differences were most pronounced in Turkish and Ghanaian women, who, by means of a simple questionnaire, reported the lowest and highest fish consumption respectively. Adjustment for fish intake, however, hardly attenuated the differences in relative EPA, DHA, DGLA and AA concentrations between the various ethnic groups. Given the limitations of this observational study, further research into the ethnicity-related differences in maternal n-3 and n-6 fatty acid patterns is warranted, particularly to elucidate the explanatory role of fatty acid intake v. metabolic differences.
KW - arachidonic acid
KW - children
KW - composition
KW - ethnic groups
KW - ethnicity
KW - fatty acids
KW - fish
KW - fish consumption
KW - nutrition
KW - phospholipids
KW - polyenoic fatty acids
KW - pregnancy
KW - questionnaires
KW - women
KW - world
KW - Morocco
KW - Netherlands
KW - Turkey
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Developing Countries
KW - Francophone Africa
KW - Africa
KW - Maghreb
KW - North Africa
KW - Mediterranean Region
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - West Asia
KW - Asia
KW - eicosatetraenoic acid
KW - ethnic differences
KW - gestation
KW - polyunsaturated fatty acids
KW - worldwide
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Aquatic Produce (QQ060)
KW - Human Reproduction and Development (VV060)
KW - Human Nutrition (General) (VV100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093204537&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=BJN
UR - email: mveijsden@ggd.amsterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Substance use disorder among older adults in the United States in 2020.
AU - Han, B.
AU - Gfroerer, J. C.
AU - Colliver, J. D.
AU - Penne, M. A.
JO - Addiction
JF - Addiction
Y1 - 2009///
VL - 104
IS - 1
SP - 88
EP - 96
CY - Oxford; UK
PB - Blackwell Publishing
SN - 0965-2140
AD - Han, B.: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20093044021. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Public Health
N2 - Aims: This study aimed to project the number of people aged 50 years or older with substance use disorder (alcohol/illicit drug dependence or abuse) in the United States in 2020. Design: Logistic regression models were applied to estimate parameters predicting past-year substance use disorder using the 2002-06 National Survey on Drug Use and Health data. We applied these parameters to the projected US 2020 population to estimate the number of adults aged 50 or older with substance use disorder in 2020. Setting: Non-institutionalized US residences. Participants: Representative sample of the US civilian, non-institutionalized population. Measurements: Substance use disorder is classified based on criteria in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Findings: Due to the large population size and high substance use rate of the baby-boom cohort, the number of adults aged 50 or older with substance use disorder is projected to double from 2.8 million (annual average) in 2002-06 to 5.7 million in 2020. Increases are projected for all examined gender, race/ethnicity and age groups. Conclusions: Our estimates provide critical information for policymakers to allocate resources and develop prevention and treatment approaches to address future needs of the US older adult population with substance use disorder.
KW - adults
KW - age
KW - alcohol intake
KW - controlled substances
KW - drug addiction
KW - epidemiological surveys
KW - estimation
KW - ethnicity
KW - human diseases
KW - sex
KW - substance abuse
KW - trends
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - alcohol consumption
KW - drugs (controlled substances)
KW - ethnic differences
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093044021&site=ehost-live&scope=site
UR - http://www.blackwell-synergy.com/loi/add
UR - email: beth.han@samhsa.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Identification and characterization of a serine protease inhibitor of Paragonimus westermani.
AU - Hwang JinHee
AU - Lee WookGyo
AU - Na ByoungKuk
AU - Lee HyeongWoo
AU - Cho ShinHyeong
AU - Kim TongSoo
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2009///
VL - 104
IS - 3
SP - 495
EP - 501
CY - Heidelberg; Germany
PB - Springer-Verlag GmbH
SN - 0932-0113
AD - Hwang JinHee: Korea Food and Drug Administration, Seoul, 122-701, Korea Republic.
N1 - Accession Number: 20093073248. Publication Type: Journal Article. Language: English. Registry Number: 9007-49-2, 9002-04-4, 9002-07-7. Subject Subsets: Veterinary Science; Public Health; Tropical Diseases; Helminthology; Veterinary Science
N2 - Paragonimus westermani is a trematode parasite that causes pulmonary and/or extrapulmonary granulomatous disease in humans. In this study, we identified a full-length gene encoding a novel serine protease inhibitor of P. westermani (PwSERPIN) and characterized the biochemical properties of the recombinant protein. PwSERPIN had an open reading frame of 1,164 bp, which encoded 387 amino acid residues. Sequence analysis of the primary structure of PwSERPIN revealed that it had the essential structural motifs which were well conserved among the serine protease inhibitor (serpin) superfamily and had shown 16.5-29.6% sequence identities with previously reported serpins from other helminthic parasites. No signal peptide or N-glycosylation site was found in the sequence. Genomic DNA structure analysis showed that PwSERPIN comprised six exons separated by five introns. The bacterially expressed recombinant PwSERPIN effectively inhibited the activities of trypsin, thrombin, and chymotrypsin in a dose-dependent manner, but showed lower inhibitory capacity on cathepsin G and elastases. Expression of PwSERPIN was detected throughout various developmental stages of the parasite, from metacercariae to adult worms, and the transcription level gradually increased with the maturation of the parasite. PwSERPIN was identified in the soluble extract of the parasite, but not in the excretory and secretory products (ESP) and in the insoluble extract of the parasite. These results collectively suggest that the PwSERPIN is an intracellular serpin of P. westermani and that might play primary roles in regulating the activities of intracellular serine proteases of the parasite.
KW - amino acids
KW - biochemistry
KW - cathepsins
KW - characterization
KW - developmental stages
KW - DNA
KW - genes
KW - genomics
KW - granuloma
KW - helminthoses
KW - helminths
KW - human diseases
KW - infections
KW - introns
KW - lungs
KW - metacercariae
KW - molecular genetics
KW - open reading frames
KW - parasites
KW - parasitology
KW - parasitoses
KW - properties
KW - proteinase inhibitors
KW - proteinases
KW - recombinant proteins
KW - residues
KW - signal peptide
KW - thrombin
KW - trypsin
KW - man
KW - Paragonimus
KW - Paragonimus westermani
KW - Trematoda
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Paragonimidae
KW - Digenea
KW - Trematoda
KW - Platyhelminthes
KW - invertebrates
KW - Paragonimus
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - growth phase
KW - ORFs
KW - parasitic diseases
KW - parasitic infestations
KW - parasitic worms
KW - parasitosis
KW - Plagiorchiida
KW - protease inhibitors
KW - proteases
KW - signal sequence
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Pesticides and Drugs (General) (HH400)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093073248&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/f8706q6k10727214/?p=3bf6b8e8caf4456c85f32a27382c0526&pi=0
UR - email: tongsookim@inha.ac.kr
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
AU - Wang YuZhu
AU - Chen Ji
AU - Chu ShiFeng
AU - Wang YongSheng
AU - Wang XiaoYing
AU - Chen NaiHong
AU - Zhang JunTian
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
Y1 - 2009///
VL - 109
IS - 4
SP - 504
EP - 510
CY - Tokyo; Japan
PB - Japanese Pharmacological Society
SN - 1347-8613
AD - Wang YuZhu: Center for Drug Evaluation, State Food and Drug Administration, Jia 1 Fuxing Road, Haidian District, Beijing 100038, China.
N1 - Accession Number: 20093151776. Publication Type: Journal Article. Language: English. Number of References: 27 ref. Subject Subsets: Aromatic & Medicinal Plants
N2 - Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step through test and electrophysiological approach to investigate the effects of ginsenoside Rg1's primary metabolite ginsenoside Rh1 and end metabolite protopanaxatriol (Ppt) on learning and memory as well as hippocampal excitability. The behavioral study showed that both ginsenoside Rh1 and Ppt significantly ameliorated memory-impaired models induced by scopolamine in mice. Consistently, the electrophysiological work revealed that ginsenoside Rh1 and Ppt as well as their precursor ginsenoside Rg1 all increased hippocampal excitability in the dentate gyrus of anesthetized rats. These results demonstrated that both ginsenoside Rh1 and Ppt had similar but more potent actions than ginsenoside Rg1 in improving memory and hippocampal excitability, suggesting the role of ginsenoside's sugar moieties in biological activities is not as necessary as traditionally considered.
KW - animal models
KW - central nervous system
KW - hippocampus
KW - memory
KW - metabolites
KW - plant extracts
KW - mice
KW - Panax
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Araliaceae
KW - Apiales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Araliales
KW - CNS
KW - Non-food/Non-feed Plant Products (SS200)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093151776&site=ehost-live&scope=site
UR - http://jps.pharmacol.org/
UR - email: zhangjt@imm.ac.cn
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET imaging using 18F-annexin V.
AU - Zhang, X.
AU - Paule, M. G.
AU - Newport, G. D.
AU - Zou, X. J.
AU - Sadovova, N.
AU - Berridge, M. S.
AU - Apana, S. M.
AU - Hanig, J. P.
AU - Slikker, W., Jr.
AU - Wang, C.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2009///
VL - 111
IS - 2
SP - 355
EP - 361
CY - Cary; USA
PB - Oxford University Press
SN - 1096-6080
AD - Zhang, X.: Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20103035449. Publication Type: Journal Article. Language: English. Registry Number: 6740-88-1. Subject Subsets: Veterinary Science; Veterinary Science
N2 - It has been reported that suppression of N-methyl-D-aspartate (NMDA) receptor function by ketamine may trigger apoptosis of neurons when given repeatedly during the brain growth spurt period. Because microPET scans can provide in vivo molecular imaging at sufficient resolution, it has been proposed as a minimally invasive method for detecting apoptosis using the tracer 18F-labeled annexin V. In this study, the effect of ketamine on the metabolism and integrity of the rat brain were evaluated by investigating the uptake and retention of 18F-fluorodeoxyglucose (FDG) and 18F-annexin V using microPET imaging. On postnatal day (PND) 7, rat pups in the experimental group were exposed to six injections of ketamine (20 mg/kg at 2-h intervals) and control rat pups received six injections of saline. On PND 35, 37 MBq (1 mCi) of 18F-FDG or 18F-annexin V was injected into the tail vein of treated and control rats, and static microPET images were obtained over 1 (FDG) and 2 h (annexin V) following the injection. No significant difference was found in 18F-FDG uptake in the regions of interest (ROIs) in the brains of ketamine-treated rats compared with saline-treated controls. The uptake of 18F-annexin V, however, was significantly increased in the ROI of ketamine-treated rats. Additionally, the duration of annexin V tracer washout was prolonged in the ketamine-treated animals. These results demonstrate that microPET imaging is capable of distinguishing differences in retention of 18F-annexin V in different brain regions and suggests that this approach may provide a minimally invasive biomarker of neuronal apoptosis in rats.
KW - animal experiments
KW - animal models
KW - biochemical markers
KW - diagnosis
KW - diagnostic techniques
KW - disease models
KW - human diseases
KW - imagery
KW - ketamine
KW - laboratory animals
KW - neurotoxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal research
KW - biomarkers
KW - positron emission tomography
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103035449&site=ehost-live&scope=site
UR - http://toxsci.oxfordjournals.org/cgi/content/abstract/111/2/355
UR - email: cheng.wang@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma.
AU - Purdue, M. P.
AU - Lan, Q.
AU - Martinez-Maza, O.
AU - Oken, M. M.
AU - Hocking, W.
AU - Huang, W. Y.
AU - Baris, D.
AU - Conde, B.
AU - Rothman, N.
JO - Blood
JF - Blood
Y1 - 2009///
VL - 114
IS - 13
SP - 2730
EP - 2732
CY - Washington; USA
PB - American Society of Hematology
SN - 0006-4971
AD - Purdue, M. P.: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
N1 - Accession Number: 20093298541. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Prediagnostic serum concentration of soluble CD30 (sCD30), a marker for chronic B-cell stimulation, has been associated with increased risk of developing AIDS-related non-Hodgkin lymphoma (NHL) in a recent study of HIV+ patients. To investigate among healthy persons whether serum sCD30 is associated with NHL risk, we carried out a nested case-control study within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. There was a strong dose-response relationship between prediagnostic sCD30 concentration and NHL risk among 234 cases and 234 individually matched controls (odds ratio [95% confidence interval] for second, third, and fourth quartiles vs first quartile: 1.4 [0.8-2.6], 2.2 [1.2-4.1], 4.1 [2.2-7.8]; Ptrend <.001), which persisted among cases diagnosed 6 to 10 years after providing a blood sample. Given that a similar relationship has been observed among HIV+ patients, our findings suggest that chronic B-cell stimulation may be an important mechanism involved in B-cell lymphomagenesis among severely immunocompromised and healthy populations alike.
KW - acquired immune deficiency syndrome
KW - B lymphocytes
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - immune response
KW - immunological deficiency
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - AIDS
KW - B cells
KW - human immunodeficiency virus infections
KW - immune deficiency
KW - immunity reactions
KW - immunodeficiency
KW - immunological reactions
KW - on-Hodgkin's lymphoma
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093298541&site=ehost-live&scope=site
UR - http://bloodjournal.hematologylibrary.org/cgi/content/abstract/114/13/2730
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Comparison of Yersinia pestis to other closely related Yersinia species using fatty acid profiles.
AU - Whittaker, P.
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2009///
VL - 116
IS - 3
SP - 629
EP - 632
CY - Oxford; UK
PB - Elsevier
SN - 0308-8146
AD - Whittaker, P.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093180117. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology; Public Health
N2 - Capillary gas chromatography with flame ionisation detection (GC-FID) was used to determine the cellular fatty acid (CFA) profiles of six Yersinia pestis strains. The profiles were then compared with the CFA profiles of other closely related Yersinia species including: Y. pseudotuberculosis, Y. enterocolitica, Y. intermedii, Y. kristensenii and Y. frederiksenii. For GC-FID analysis, whole cell fatty acid methyl esters (FAMEs) from cells cultured on brain-heart infusion (BHI) agar at 35°C for 24 h were obtained by saponification, methylation and extraction into hexane/methyl tert-butyl ether. A data set for each Yersinia species was prepared using fatty acid profiles from five replicates prepared on different days. Major fatty acids of the 26 Yersinia strains evaluated in this study were straight-chain 12:0, 14:0, 15:0, 16:0 and unsaturated summed 16:1 ω7c/16:1 ω6c, 18:1 ω7c, and summed 14:0 3OH/16:1 iso, and 17:0 ω cyclo 7-8. The CFA profiles for Y. pestis and Y. pseudotuberculosis are similar, but there are several fatty acids, 16:1 ω5c, 16:0, 17:1 ω7c, 17:0 ω cyclo 7-8, 19:0 and summed 18:2 ω6c, 9c/18:0 ante, that differ significantly between these two species. Analysis of FAMEs from Yersinia strains grown on BHI agar by a rapid GC-FID method can provide a sensitive procedure for the identification of these organisms, and this analytical method provides a procedure for the differentiation of Y. pestis strains from closely related Yersinia species.
KW - fatty acids
KW - Yersinia enterocolitica
KW - Yersinia frederiksenii
KW - Yersinia intermedia
KW - Yersinia kristensenii
KW - Yersinia pestis
KW - Yersinia pseudotuberculosis
KW - Yersinia (Bacteria)
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093180117&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/03088146
UR - email: paul.whittaker@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational exposure to polychlorinated biphenyls and risk of breast cancer.
AU - Silver, S. R.
AU - Whelan, E. A.
AU - Deddens, J. A.
AU - Steenland, N. K.
AU - Hopf, N. B.
AU - Waters, M. A.
AU - Ruder, A. M.
AU - Prince, M. M.
AU - Yong, L. C.
AU - Hein, M. J.
AU - Ward, E. M.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009///
VL - 117
IS - 2
SP - 276
EP - 282
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Silver, S. R.: Industrywide Studies Branch, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093069919. Publication Type: Journal Article. Language: English. Number of References: 30 ref. Subject Subsets: Public Health
N2 - Background: Despite the endocrine system activity exhibited by polychlorinated biphenyls (PCBs), recent studies have shown little association between PCB exposure and breast cancer mortality. Objectives: To further evaluate the relation between PCB exposure and breast cancer risk, we studied incidence, a more sensitive end point than mortality, in an occupational cohort. Methods: We followed 5,752 women employed for at least 1 year in one of three capacitor manufacturing facilities, identifying cases from questionnaires, cancer registries, and death certificates through 1998. We collected lifestyle and reproductive information via questionnaire from participants or next of kin and used semiquantitative job-exposure matrices for inhalation and dermal exposures combined. We generated standardized incidence ratios (SIRs) and standardized rate ratios and used Cox proportional hazards regression models to evaluate potential confounders and effect modifiers. Results: Overall, the breast cancer SIR was 0.81 (95% confidence interval, 0.72-0.92; n=257), and regression modeling showed little effect of employment duration or cumulative exposure. However, for the 362 women of questionnaire-identified races other than white, we observed positive, statistically significant associations with employment duration and cumulative exposure; only smoking, birth cohort, and self- or proxy questionnaire completion had statistically significant explanatory power when added to models with exposure metrics. Conclusions: We found no overall elevation in breast cancer risk after occupational exposure to PCBs. However, the exposure-related risk elevations seen among nonwhite workers, although of limited interpretability given the small number of cases, warrant further investigation, because the usual reproductive risk factors accounted for little of the increased risk.
KW - breast cancer
KW - human diseases
KW - neoplasms
KW - occupational hazards
KW - occupational health
KW - polychlorinated biphenyls
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - PCBs
KW - United States of America
KW - Occupational Health and Safety (VV900)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093069919&site=ehost-live&scope=site
UR - http://www.ehponline.org/members/2008/11774/11774.html
UR - email: SSilver@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - A reconsideration of acute beryllium disease.
AU - Cummings, K. J.
AU - Stefaniak, A. B.
AU - Virji, M. A.
AU - Kreiss, K.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009///
VL - 117
IS - 8
SP - 1250
EP - 1256
CY - Research Triangle Park; USA
PB - Public Health Service, U.S. Department of Health and Human Services
SN - 0091-6765
AD - Cummings, K. J.: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., MS-2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093231587. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - Context: Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the pathophysiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers. Case Presentation: Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 µg/m3, and most were <10 µg/m3, lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD. Discussion: Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved. Relevance to Practice: ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD.
KW - berylliosis
KW - beryllium
KW - case reports
KW - chronic diseases
KW - clinical aspects
KW - exposure
KW - human diseases
KW - hypersensitivity
KW - occupational disorders
KW - occupational health
KW - physiopathology
KW - workers
KW - USA
KW - West Virginia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Appalachian States of USA
KW - Southern States of USA
KW - USA
KW - South Atlantic States of USA
KW - acute diseases
KW - allergic responses
KW - clinical picture
KW - hypersensitiveness
KW - pathophysiology
KW - United States of America
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Human Health and the Environment (VV500)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093231587&site=ehost-live&scope=site
UR - http://www.ehponline.org/members/2009/0800455/0800455.html
UR - email: cvx5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intravenous ribavirin-review of the FDA's emergency investigational new drug database (1997-2008) and literature review.
AU - Riner, A.
AU - Chan-Tack, K. M.
AU - Murray, J. S.
JO - Postgraduate Medicine
JF - Postgraduate Medicine
Y1 - 2009///
VL - 121
IS - 3
SP - 139
EP - 146
CY - New York; USA
PB - McGraw-Hill Companies, Inc.
SN - 0032-5481
AD - Riner, A.: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Building 22, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20093243043. Publication Type: Journal Article. Language: English. Number of References: 66 ref. Registry Number: 36791-04-5. Subject Subsets: Public Health
N2 - Intravenous (IV) ribavirin does not have US Food and Drug Administration (FDA) approval, although oral and aerosol formulations have been approved. Intravenous ribavirin can, however, be authorized for use as a result of an Emergency Investigational New Drug (EIND) application as investigational treatment for patients with serious viral infections, including emerging or rare infections for which no alternative treatment is available. This retrospective study evaluated clinical experience with IV ribavirin based on a review of the FDA's EIND database and a literature review. The main outcome measures were disease condition, clinical outcomes, and adverse events (AEs). First, the FDA's EIND database was evaluated for these variables among patients authorized to receive investigational IV ribavirin. Second, published literature on IV ribavirin was reviewed for diseases treated, reported clinical outcomes, and AEs. Adverse events reported in the literature were compared with AEs listed in approved product labeling (aerosol and oral formulations). From February 1997 to December 2008, 608 IV ribavirin EIND requests were made for 19 disease conditions. Adenovirus, respiratory syncytial virus, and parainfluenza infections comprised 84.7% of IV ribavirin EINDs. Inadequate reporting of clinical outcomes and AEs in the EIND database prevented analysis of either outcome. Data interpretation in the literature was limited by multiple factors, including retrospective design, small sample sizes, differences in reporting outcomes and AEs, lack of generalizability, and potential confounders such as concomitant medications, selection bias, and reporting bias. Reported AEs were consistent with labels of approved aerosol and oral formulations, except for lip and gingival swelling. However, estimates of frequency, severity, and causality of AEs associated with IV ribavirin could not be determined because of study limitations. Our study findings suggest that the literature is inconclusive on the potential benefit for continued use of IV ribavirin. A review of the literature and the FDA's EIND database suggests that prospective, controlled trials of IV ribavirin in patients with adenovirus, parainfluenza, or serious respiratory syncytial virus infections could be feasible.
KW - adverse effects
KW - antiviral agents
KW - drug therapy
KW - human diseases
KW - Parainfluenza viruses
KW - ribavirin
KW - viral diseases
KW - Human adenovirus
KW - Human respiratory syncytial virus
KW - man
KW - Mastadenovirus
KW - Adenoviridae
KW - dsDNA viruses
KW - DNA viruses
KW - viruses
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Paramyxovirinae
KW - adverse reactions
KW - chemotherapy
KW - tribavirin
KW - viral infections
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093243043&site=ehost-live&scope=site
UR - http://www.postgradmed.com/index.php?free=pgm_05_2009?article=2014&ex=2014
UR - email: jeffrey.murray@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Impact of a novel way to communicate information about MMR on uptake of MMR vaccine: a randomized controlled trial.
AU - Porter-Jones, G.
AU - Williams, S.
AU - Powell, C.
AU - Pusey, L.
AU - Roberts, R. J.
JO - Public Health
JF - Public Health
Y1 - 2009///
VL - 123
IS - 1
SP - 78
EP - 80
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Porter-Jones, G.: Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold CH7 1PZ, UK.
N1 - Accession Number: 20093072682. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
N2 - This article presents a randomized controlled trial carried out in Wales, UK to assess the impact on first dose measles-mumps-rubella (MMR1) vaccine uptake of issuing teddy bears wearing T-shirts displaying a website address (www.mmrmyths.com) and telephone number providing information about MMR. The results of this trial are summarized, which indicate that this novel method of promoting sources of information about MMR vaccination does not appear to have influenced MMR1 vaccine uptake.
KW - campaigns
KW - disease prevention
KW - health education
KW - human diseases
KW - immunization
KW - infants
KW - internet
KW - measles
KW - measles mumps rubella vaccines
KW - mumps
KW - randomized controlled trials
KW - rubella
KW - vaccination
KW - UK
KW - Wales
KW - man
KW - Measles virus
KW - Mumps virus
KW - Rubella virus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Morbillivirus
KW - Paramyxovirinae
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Rubulavirus
KW - Rubivirus
KW - Togaviridae
KW - positive-sense ssRNA viruses
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - German measles
KW - immune sensitization
KW - United Kingdom
KW - Information and Documentation (CC300)
KW - Host Resistance and Immunity (HH600)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093072682&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: gary.porter-jones@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Access to the medical home: new findings from the 2005-2006 National Survey of Children With Special Health Care Needs.
AU - Strickland, B. B.
AU - Singh, G. K.
AU - Kogan, M. D.
AU - Mann, M. Y.
AU - Dyck, P. C. van
AU - Newacheck, P. W.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009///
VL - 123
IS - 6
SP - e996
EP - e1004
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Strickland, B. B.: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093206266. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - OBJECTIVE. This article reports new findings from the 2005-2006 National Survey of Children with Special Health Care Needs (NS-CSHCN) regarding parental perceptions of the extent to which children with special health care needs (CSHCN) have access to a medical home. METHODS. Five criteria were analyzed to describe the extent to which CSHCN receive care characteristic of the medical home concept. Data on 40840 children included in the NS-CSHCN were used to assess the presence of a medical home, as indicated by achieving each of the 5 criteria. RESULTS. Results of the survey indicate that (1) approximately one half of CSHCN receive care that meets all 5 criteria established for a medical home; (2) access to a medical home is affected significantly by race/ethnicity, income, health insurance status, and severity of the child's condition; (3) parents of children who do have a medical home report significantly less delayed or forgone care and significantly fewer unmet needs for health care and family support services; and (4) limited improvements have occurred since success rates were first measured by using the 2001 NS-CSHCN. CONCLUSIONS. The findings suggest that, although some components of the medical home concept have been achieved for most CSHCN, care synonymous with the principles underlying the medical home is not yet in place for a significant number of CSHCN and their families.
KW - attitudes
KW - children
KW - health care
KW - health centres
KW - health services
KW - parents
KW - surveys
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - health centers
KW - United States of America
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093206266&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Active cigarette smoking, secondhand smoke exposure at work and home, and self-rated health.
AU - Nakata, A.
AU - Takahashi, M.
AU - Swanson, N. G.
AU - Ikeda, T.
AU - Hojou, M.
JO - Public Health
JF - Public Health
Y1 - 2009///
VL - 123
IS - 10
SP - 650
EP - 656
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Nakata, A.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20103026865. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - Objectives: Although active smoking has been reported to be associated with poor self-rated health (SRH), its association with secondhand smoke (SHS) is not well understood. Study design: A cross-sectional study was conducted to examine the association of active smoking and SHS exposure with SRH. Methods: A total of 2558 workers (1899 men and 689 women), aged 16-83 (mean 45) years, in 296 small and medium-sized enterprises were surveyed by means of a self-administered questionnaire. Smoking status and exposure levels to SHS (no, occasional or regular) among lifetime non-smokers were assessed separately at work and at home. SRH was assessed with the question: How would you describe your health during the past 1-year period (very poor, poor, good, very good)? SRH was dichotomized into suboptimal (poor, very poor) and optimal (good, very good). Odds ratios (ORs) with 95% confidence intervals (CIs) for reporting suboptimal vs optimal SRH according to smoking status and smoke exposure were calculated. Results: Current heavy smokers (20+ cigarettes/day) had a significantly increased suboptimal SRH than lifetime non-smokers after adjusting for sociodemographic, lifestyle, physical and occupational factors (OR 1.34, 95% CI 1.06-1.69). Similarly, lifetime non-smokers occasionally exposed to SHS at work alone had worse SRH than their unexposed counterparts (OR 1.50, 95% CI 1.02-2.11). In contrast, lifetime non-smokers exposed at home alone had no significant increase in suboptimal SRH. Conclusions: The present study indicates an increase in suboptimal SRH among current heavy smokers, and suggests that SHS exposure at work is a possible risk factor for non-smokers. Whether or not the association is causal, control of smoking at work may protect workers from developing future health conditions.
KW - cigarettes
KW - exposure
KW - medical auxiliaries
KW - men
KW - occupational health
KW - questionnaires
KW - risk factors
KW - tobacco smoking
KW - women
KW - workers
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - allied health occupations
KW - health workers
KW - Human Health and the Environment (VV500)
KW - Occupational Health and Safety (VV900)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103026865&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: cji5@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Seasonal variation in self-reported health and health-related behaviour in Dutch adolescents.
AU - Looij-Jansen, P. M. van de
AU - Wilde, E. J. de
AU - Mieloo, C. L.
AU - Donker, M. C. H.
AU - Verhulst, F. C.
JO - Public Health
JF - Public Health
Y1 - 2009///
VL - 123
IS - 10
SP - 686
EP - 688
CY - Oxford; UK
PB - Elsevier
SN - 0033-3506
AD - Looij-Jansen, P. M. van de: Youth Department, Municipal Public Health Service for Rotterdam Area, P.O. Box 70032, 3000 LP, Rotterdam, Netherlands.
N1 - Accession Number: 20103026871. Publication Type: Journal Article. Language: English. Number of References: 10 ref. Subject Subsets: Public Health
KW - adolescents
KW - children
KW - health
KW - seasonal variation
KW - Netherlands
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Benelux
KW - Developed Countries
KW - European Union Countries
KW - Kingdom of the Netherlands
KW - OECD Countries
KW - Western Europe
KW - Europe
KW - seasonal changes
KW - seasonal fluctuations
KW - teenagers
KW - Human Health and the Environment (VV500)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103026871&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00333506
UR - email: vandelooijp@ggd.rotterdam.nl
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome.
AU - Melia, E.
AU - Freeman, A. F.
AU - Shea, Y. R.
AU - Hsu, A. P.
AU - Holland, S. M.
AU - Olivier, K. N.
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
Y1 - 2009///
VL - 124
IS - 3
SP - 617
EP - 618
CY - New York; USA
PB - Elsevier
SN - 0091-6749
AD - Melia, E.: The Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
N1 - Accession Number: 20093292033. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Medical & Veterinary Mycology; Agricultural Biotechnology; Public Health
N2 - A review of nontuberculous mycobacteria (NTM) infections was conducted in a cohort of patients with hyper-IgE syndrome (HIES). Microbiology records from April 1977 to November 2007 were queried for lower respiratory tract specimen mycobacterial smear and culture results. From these, 3 groups were identified: patients with positive NTM cultures and who met the American Thoracic Society (ATS) disease criteria [NTM+/ATS(+)], patients positive for NTM but did not meet ATS criteria [NTM+/ATS(minus)], and patients negative for NTM [NTM-/ATS(-)]. ANOVA and χ2 tests were used in data analysis. It was observed that 30 of 32 HIES patients tested (17 female; aged 2-56 years, 31±14 years at the time of culture; HIES clinical score, 52-100 [79±12]) had STAT3 mutation and 9 (28%) patients grew NTM on at least 1 occasion. Of the 5 (16%) NTM+/ATM(+) patients, 3 grew Mycobacterium avium, 2 grew M. kansasii, and 3 separately grew M. massiliense, M. mucogenicum, and M. intracellulare (more than 1 species grew in 3 patients). NTM+/ATS(+) also grew 10 other potential pathogens; Aspergillus fumigatus and Pseudomonas aeruginosa were the most common. Moreover, of the 4 NTM+/ATS(-) patients, 2 grew M. avium, 1 grew M. chelonae, and 1 grew M. abscessus, while 2 patients also grew A. fumigatus, Staphylococcus aureus, and Haemophilus influenzae. NTM-/ATS(-) grew 17 other organisms with H. influenzae being the most frequent (43%). There were more female patients in the NTM+/ATS(+) group (80%, P < 0.05) than in the NTM+/ATS(-) and NTM-/ATS(-) groups (none and 57% respectively). All NTM+/ATS(+) and 3 NTM+/ATS(-) patients had at least 10° of scoliosis; 63% of NTM-/ATS(-) patients had scoliosis. No difference was found in the percent predicted FEV1 of the groups. Bronchiectasis and cysts were identified in patients with NTM. Among NTM-patients, 4 (17%) of 23 had normal lungs on CT scans, bronchiectasis was found in 10 (34%), cysts and nodules were found in 8 (35%), and alveolar infiltrates were found in 7 (30%). The prevalence of bronchiectasis and cysts was significantly different among the groups (P < 0.05). Treatment for NTM was initiated in NTM+/ATS(+) patients and all showed microbiologic and/or radiologic improvement.
KW - bacterial diseases
KW - Bronchiectasis
KW - cultures
KW - cysts (pathological)
KW - genes
KW - human diseases
KW - immunological diseases
KW - influenza
KW - mutations
KW - mycobacterial diseases
KW - mycoses
KW - nodules
KW - respiratory diseases
KW - scoliosis
KW - smears
KW - spinal diseases
KW - viral diseases
KW - Aspergillus fumigatus
KW - Haemophilus influenzae
KW - man
KW - Mycobacterium abscessus
KW - Mycobacterium avium complex
KW - Mycobacterium chelonae
KW - Mycobacterium intracellulare
KW - Mycobacterium kansasii
KW - Mycobacterium massiliense
KW - Mycobacterium mucogenicum
KW - Pseudomonas aeruginosa
KW - Staphylococcus aureus
KW - Aspergillus
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Haemophilus
KW - Pasteurellaceae
KW - Pasteurellales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Mycobacterium
KW - Mycobacteriaceae
KW - Corynebacterineae
KW - Actinomycetales
KW - Actinobacteridae
KW - Actinobacteria
KW - Pseudomonas
KW - Pseudomonadaceae
KW - Pseudomonadales
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - flu
KW - fungus
KW - hyper-IgE syndrome
KW - Hyphomycetes
KW - lung diseases
KW - mycobacterial infections
KW - STAT3
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093292033&site=ehost-live&scope=site
UR - http://www.mosby.com/jaci
UR - email: olivierk@niaid.nih.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Progress in ensuring adequate health insurance for children with special health care needs.
AU - Honberg, L. E.
AU - Kogan, M. D.
AU - Allen, D.
AU - Strickland, B. B.
AU - Newacheck, P. W.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009///
VL - 124
IS - 5
SP - 1273
EP - 1280
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Honberg, L. E.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20103001594. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Subject Subsets: Public Health
N2 - OBJECTIVE: This article reports findings from the 2005-2006 National Survey of Children With Special Health Care Needs (NS-CSHCN) regarding the extent to which CSHCN have access to public or private health insurance that meets their needs. METHODS: The HRSA Maternal and Child Health Bureau's health insurance core outcome was measured on the basis of whether a child had public or private coverage at the time of survey; continuity of coverage during the previous 12 months; and adequacy of coverage. Bivariate and multivariate statistical methods were used to assess independent predictors of respondents who met the health insurance core outcome and the impact of meeting the core outcome on measures of access and financial burden. Comparisons with a referent sample of children who did and did not have special needs and were included in the 2001 NS-CSHCN are also presented. RESULTS: A total of 62.0% of CSHCN nationally met the health insurance core outcome in 2005-2006, up from 59.6% in 2001. Disparities by ethnicity and income remain, but some have narrowed, especially for Hispanic CSHCN. Children who did not meet the health insurance core outcome were more likely to have unmet needs and their families to experience financial problems. CSHCN were more likely to be insured than children without special needs but less likely to be adequately insured. CONCLUSIONS: Results of the survey demonstrate that although a growing number of CSHCN have continuous and adequate health insurance, additional effort is needed to improve the adequacy of that insurance, particularly for children in vulnerable subpopulations.
KW - children
KW - health insurance
KW - health services
KW - statistical analysis
KW - surveys
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - statistical methods
KW - United States of America
KW - Health Economics (EE118) (New March 2000)
KW - Health Services (UU350)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Mathematics and Statistics (ZZ100)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103001594&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: lhonberg@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007.
AU - Kogan, M. D.
AU - Blumberg, S. J.
AU - Schieve, L. A.
AU - Boyle, C. A.
AU - Perrin, J. M.
AU - Ghandour, R. M.
AU - Singh, G. K.
AU - Strickland, B. B.
AU - Trevathan, E.
AU - Dyck, P. C. van
JO - Pediatrics
JF - Pediatrics
Y1 - 2009///
VL - 124
IS - 5
SP - 1395
EP - 1403
CY - Elk Grove Village; USA
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Kogan, M. D.: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA.
N1 - Accession Number: 20103001607. Publication Type: Journal Article. Language: English. Number of References: 48 ref. Subject Subsets: Public Health
N2 - OBJECTIVES: The reported increasing prevalence of autism spectrum disorder (ASD) and attendant health and family impact make monitoring of ASD prevalence a public health priority. METHODS: The prevalence of parent-reported diagnosis of ASD among US children aged 3 to 17 years was estimated from the 2007 National Survey of Children's Health (sample size: 78037). A child was considered to have ASD if a parent/guardian reported that a doctor or other health care provider had ever said that the child had ASD and that the child currently had the condition. The point-prevalence for ASD was calculated for those children meeting both criteria. We examined sociodemographic factors associated with current ASD and with a past (but not current) ASD diagnosis. The health care experiences for children in both ASD groups were explored. RESULTS: The weighted current ASD point-prevalence was 110 per 10,000. We estimate that 673,000 US children have ASD. Odds of having ASD were 4 times as large for boys than girls. Non-Hispanic (NH) black and multiracial children had lower odds of ASD than NH white children. Nearly 40% of those ever diagnosed with ASD did not currently have the condition; NH black children were more likely than NH white children to not have current ASD. Children in both ASD groups were less likely than children without ASD to receive care within a medical home. CONCLUSIONS: The observed point-prevalence is higher than previous US estimates. More inclusive survey questions, increased population awareness, and improved screening and identification by providers may partly explain this finding.
KW - autism
KW - children
KW - disease prevalence
KW - epidemiology
KW - human diseases
KW - mental disorders
KW - parents
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - mental illness
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103001607&site=ehost-live&scope=site
UR - http://pediatrics.aappublications.org
UR - email: mkogan@hrsa.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Formative research in occupational health and safety intervention for diverse, underserved worker populations: a homecare worker intervention project.
AU - Gong, F.
AU - Baron, S.
AU - Stock, L.
AU - Ayala, L.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009///
VL - 124
IS - supp. 1
SP - 84
EP - 89
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Gong, F.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy., MS R-17, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093203030. Publication Type: Journal Article. Language: English. Number of References: 17 ref. Subject Subsets: Public Health
N2 - Objective. The increasing numbers of minority, low-income, and contingent workers in the U.S. labor force present new challenges to occupational safety and health interventions. Formative research can be used to help researchers better understand target populations and identify unanticipated barriers to safety changes. The National Institute for Occupational Safety and Health initiated an intervention project to improve health and safety among homecare workers in Alameda County, California. Investigators conducted systematic formative research to gather information to guide intervention development. Methods. Various qualitative methods were used including 11 focus groups (conducted in English, Spanish, and Chinese) and 10 key informant interviews. This article focuses on two picture-based focus group activities that explored workers' views on their relationships with consumers and their perceived barriers to interventions. Results. Findings indicated cultural differences regarding workers' perceptions of their relationships with consumers. Chinese homecare workers mostly focused on respecting elders rather than initiating changes. Some English- and Spanish-speaking workers described efforts to negotiate with consumers. Results also identified workers' perceived barriers to interventions, such as consumers' resistance to changes and lack of resources. These findings played important roles in shaping the intervention materials. For example, given the lack of resources among consumers, the project tried to tap into community-level resources by collaborating with local stakeholders and developing community resource guides. Conclusion. Formative research can be a valuable step to inform the development of occupational health and safety interventions for diverse, underserved worker populations.
KW - attitudes
KW - culture
KW - low income groups
KW - occupational health
KW - safety
KW - safety at work
KW - workers
KW - California
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Pacific States of USA
KW - Western States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - occupational safety
KW - United States of America
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093203030&site=ehost-live&scope=site
UR - http://www.publichealthreports.org
UR - email: sbaron@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Efficacy of a program to prevent beryllium sensitization among new employees at a copper-beryllium alloy processing facility.
AU - Thomas, C. A.
AU - Bailey, R. L.
AU - Kent, M. S.
AU - Deubner, D. C.
AU - Kreiss, K.
AU - Schuler, C. R.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009///
VL - 124
IS - supp. 1
SP - 112
EP - 124
CY - Washington; USA
PB - Association of Schools of Public Health
SN - 0033-3549
AD - Thomas, C. A.: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, 1095 Willowdale Rd., MS-2800, Morgantown, WV 26505, USA.
N1 - Accession Number: 20093203033. Publication Type: Journal Article. Language: English. Number of References: 35 ref. Registry Number: 7440-41-7. Subject Subsets: Public Health
N2 - Objectives. In 2000, 7% of workers at a copper-beryllium facility were beryllium sensitized. Risk was associated with work near a wire annealing/pickling process. The facility then implemented a preventive program including particle migration control, respiratory and dermal protection, and process enclosure. We assessed the program's efficacy in preventing beryllium sensitization. Methods. In 2000, the facility began testing new hires (program workers) with beryllium lymphocyte proliferation tests (BeLPTs) at hire and at intervals during employment. We compared sensitization incidence rates (IRs) and prevalence rates for workers hired before the program (legacy workers) with rates for program workers, including program worker subgroups. We also examined trends in BeLPTs from a single laboratory. Results. In all, five of 43 legacy workers (IR=3.8/1,000 person-months) and three of 82 program workers (IR=1.9/1,000 person-months) were beryllium sensitized, for an incidence rate ratio (IRR) of 2.0 (95% confidence interval [CI] 0.5, 10.1). Two of 37 pre-enclosure program workers (IR=2.4/1,000 person-months) and one of 45 post-enclosure program workers (IR=1.4/1,000 person-months) were beryllium sensitized, for IRRs of 1.6 (95% CI 0.3, 11.9) and 2.8 (95% CI 0.4, 66.2), respectively, compared with legacy workers. Test for trend in prevalence rates was significant. Among 2,159 first-draw BeLPTs during 95 months, we identified seven months when high numbers of redraws were required, with one possible misclassification in this facility. Conclusions. Fewer workers became sensitized after implementation of the preventive program. However, low statistical power due to the facility's small workforce prevents a definitive conclusion about the program's efficacy. These findings have implications for other copper-beryllium facilities, where program components may merit application.
KW - beryllium
KW - occupational hazards
KW - occupational health
KW - personnel
KW - risk reduction
KW - safety at work
KW - workers
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - employees
KW - occupational safety
KW - staff
KW - United States of America
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093203033&site=ehost-live&scope=site
UR - http://www.publichealthreports.org
UR - email: Carrie.Thomas@cdc.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Effect of long chain fatty acids on Salmonella killing, superoxide and nitric oxide production by chicken macrophages.
AU - Babu, U.
AU - Wiesenfeld, P.
AU - Gaines, D.
AU - Raybourne, R. B.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009///
VL - 132
IS - 1
SP - 67
EP - 72
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Babu, U.: Immunobiology Branch, Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20093156674. Publication Type: Journal Article. Language: English. Registry Number: 10102-43-9, 9054-89-1. Subject Subsets: Poultry; Human Nutrition
N2 - The objective of this study was to investigate the effect of uptake of different commonly consumed long chain fatty acids on superoxide (O2-), nitric oxide (NO) production, and ability to kill Salmonella enterica serotype typhimurium (S. typhimurium) by chicken macrophages (HD11 cells). All the fatty acids were taken up by HD11 cells with stearic acid uptake higher than polyunsaturated fatty acids. Uptake of green fluorescent protein-labeled bacteria and the viability of HD11 cells (measured by flow cytometry) was not affected by any of the fatty acids tested. Bacterial clearance (measured by the plating of sorted viable infected cells) was significantly higher with n-3 fatty acids α-linolenic acid (ALA) and docosahexanoic acid (DHA). However, stearic acid (SA) and the n-6 fatty acid, arachidonic acid (ARA) did not influence S. typhimurium killing by HD11 cells. The improved S. typhimurium clearance by ALA and DHA was not associated with increased NO or O2- production by HD11 cells. These results suggest a role for n-3 polyunsaturated fatty acids in Salmonella clearance by chicken macrophages however in vivo studies are essential to confirm their efficacy in controlling Salmonella infection in chickens and contamination in shell eggs.
KW - long chain fatty acids
KW - macrophages
KW - nitric oxide
KW - polyenoic fatty acids
KW - poultry
KW - salmonellosis
KW - superoxide dismutase
KW - Salmonella
KW - Salmonella Typhimurium
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - bacterium
KW - domesticated birds
KW - polyunsaturated fatty acids
KW - Salmonella infections
KW - Animal Immunology (LL650) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093156674&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-4VYP8Y5-3&_user=10&_coverDate=06%2F01%2F2009&_rdoc=10&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235061%232009%23998679998%231092110%23FLA%23display%23Volume)&_cdi=5061&_sort=d&_docanchor=&_ct=11&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=91ecc68610286713b089bc849d726491
UR - email: uma.babu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Internal contamination and spoilage of harvested apples by patulin-producing and other toxigenic fungi.
AU - Tournas, V. H.
AU - Memon, S. U.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009///
VL - 133
IS - 1/2
SP - 206
EP - 209
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Tournas, V. H.: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093201207. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition; Plant Pathology; Horticultural Science; Postharvest Research
N2 - A total of 424 apple samples comprised of six varieties (Gala, Red Delicious, Golden Delicious, Fuji, Granny Smith, and Braeburn) were analyzed for internal fungal contamination. Two hundred sixteen apples were incubated intact for 2-4 weeks at room temperature. The cores of the remaining 208 apples were aseptically removed and incubated without supplemental media at room temperature for 3 weeks. After the incubation period was over, the mycological profiles of the analyzed samples were determined. Twelve per cent of the intact apples showed visible growth after 2-4 weeks of incubation at room temperature. Penicillia (including the patulin producer, Penicillium expansum) were the most frequent, found in 8% of the samples followed by Fusarium and Alternaria spp. (each found in 3% of the samples tested). The highest mould incidence was observed in the Red Delicious and Fuji and the lowest in the Granny Smith variety. A variety of microfungi including members of the toxigenic genera Alternaria, Penicillium and Fusarium were isolated from the apple cores. The predominant moulds were Alternaria, Cladosporium, Penicillium and Fusarium spp. recovered from 50, 22, 33 and 23% of the analyzed samples, respectively. Less common were Ulocladium spp., Botrytis cinerea and Aureobasidium pullulans found in less than 4% of the samples. Yeasts were found only in 2% of the samples. Apple cores from all varieties tested showed a high degree of mould contamination.
KW - apples
KW - cultivars
KW - food contamination
KW - food microbiology
KW - microbial contamination
KW - plant pathogenic fungi
KW - plant pathogens
KW - spoilage organisms
KW - Alternaria
KW - Aureobasidium pullulans
KW - Botrytis cinerea
KW - Cladosporium
KW - fungi
KW - Fusarium
KW - Malus
KW - Penicillium expansum
KW - Pleosporaceae
KW - Pleosporales
KW - Dothideomycetes
KW - Pezizomycotina
KW - Ascomycota
KW - fungi
KW - eukaryotes
KW - Aureobasidium
KW - Dothioraceae
KW - Dothideales
KW - Botrytis
KW - Sclerotiniaceae
KW - Helotiales
KW - Leotiomycetes
KW - Davidiellaceae
KW - Capnodiales
KW - Nectriaceae
KW - Hypocreales
KW - Sordariomycetes
KW - Rosaceae
KW - Rosales
KW - dicotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - Penicillium
KW - Trichocomaceae
KW - Eurotiales
KW - Eurotiomycetes
KW - cultivated varieties
KW - food contaminants
KW - fungus
KW - Hyphomycetes
KW - phytopathogenic fungi
KW - phytopathogens
KW - plant-pathogenic fungi
KW - Horticultural Crops (FF003) (New March 2000)
KW - Viral, Bacterial and Fungal Diseases of Plants (FF610) (New March 2000)
KW - Crop Produce (QQ050)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093201207&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-4WD7B1X-1&_user=10&_coverDate=07%2F31%2F2009&_rdoc=28&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235061%232009%23998669998%231250049%23FLA%23display%23Volume)&_cdi=5061&_sort=d&_docanchor=&_ct=29&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=9858f069de167579d9aa79b4ef542a99
UR - email: valerie.tournas@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Method for the isolation and detection of Enterobacter sakazakii (Cronobacter) from powdered infant formula.
AU - Lampel, K. A.
AU - Chen, Y.
A2 - Iversen, C.
A2 - Fanning, S.
T3 - Cronobacter special issue.
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009///
VL - 136
IS - 2
SP - 179
EP - 184
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0168-1605
AD - Lampel, K. A.: Division of Microbiology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.
N1 - Accession Number: 20093338257. Publication Type: Journal Article. Note: Cronobacter special issue. Language: English. Subject Subsets: Human Nutrition; Dairy Science
N2 - In the United States, there are approximately 76 million foodborne cases annually. Although the number of food-related infections caused by Enterobacter sakazakii is relatively low, the United States Food and Drug Administration in 2002 became concerned about the incidence of E. sakazakii infections related to powdered infant formula (PIF). At that time, a method to isolate this pathogen from PIF was developed and implemented in several cases. This protocol requires multiple steps and up to 7 days to complete. Recently, a new method was developed that incorporates a real-time PCR-based assay and chromogenic agars to improve isolating and detecting this pathogen in PIF. The updated protocol has undergone and successfully concluded an AOAC pre-collaborative study and is in the process of further validation for the inclusion into the FDA's Bacteriological Analytical Manual. This manuscript describes the performance evaluation of the new method.
KW - detection
KW - dried milk
KW - food contamination
KW - foodborne diseases
KW - infant formulae
KW - isolation
KW - laboratory methods
KW - polymerase chain reaction
KW - Enterobacter sakazakii
KW - Enterobacteriaceae
KW - Enterobacter
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - bacterium
KW - Cronobacter
KW - food contaminants
KW - infant formula
KW - infant formulas
KW - laboratory techniques
KW - milk powder
KW - PCR
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Milk and Dairy Produce (QQ010)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093338257&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7K-4X1SB3P-4&_user=10&_coverDate=12%2F31%2F2009&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235061%232009%23998639997%231562090%23FLA%23display%23Volume)&_cdi=5061&_sort=d&_docanchor=&_ct=17&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fcad7a2778fcffc52d3085efc671982a
UR - email: Keith.lampel@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Incidence of hepatitis C in drug injectors: the role of homelessness, opiate substitution treatment, equipment sharing, and community size.
AU - Craine, N.
AU - Hickman, M.
AU - Parry, J. V.
AU - Smith, J.
AU - Walker, A. M.
AU - Russell, D.
AU - Nix, B.
AU - May, M.
AU - McDonald, T.
AU - Lyons, M.
JO - Epidemiology and Infection
JF - Epidemiology and Infection
Y1 - 2009///
VL - 137
IS - 9
SP - 1255
EP - 1265
CY - Cambridge; UK
PB - Cambridge University Press
SN - 0950-2688
AD - Craine, N.: National Public Health Service for Wales, Health Protection Team, Ysbyty Gwynedd, Bangor LL57 2PW, Wales, UK.
N1 - Accession Number: 20093222806. Publication Type: Journal Article. Language: English. Number of References: 31 ref. Subject Subsets: Public Health
N2 - A prospective cohort study estimated the incidence of hepatitis C virus (HCV) in drug injectors in South Wales (UK). In total, 286/481 eligible seronegative individuals were followed up after approximately 12 months. Dried blood spot samples were collected and tested for anti-HCV antibody and behavioural data were collected at baseline and follow-up. HCV incidence was 5.9/100 person-years [95% confidence interval (CI) 3.4-9.5]. HCV incidence was predicted by community size [incident rate ratio (IRR) 6.6, 95% CI 2.11-20.51, P=0.001], homelessness (IRR 2.9, 95% CI 1.02-8.28, P=0.047) and sharing injecting equipment (IRR 12.7, 95% CI 1.62-99.6, P=0.015). HCV incidence was reduced in individuals in opiate substitution treatment (IRR 0.34, 95% CI 0.12-0.99, P=0.047). In order to reduce follow-up bias we used multiple imputation of missing data using switching regression; after imputation estimated HCV incidence was 8.5/100 person-years (95% CI 5.4-12.7). HCV incidence varies with community size, equipment sharing and homelessness are associated with increased HCV incidence and opiate substitution treatment may be protective against HCV.
KW - disease incidence
KW - epidemiology
KW - hepatitis C
KW - human diseases
KW - injecting drug users
KW - needle sharing
KW - UK
KW - Wales
KW - Hepatitis C virus
KW - man
KW - Hepacivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - British Isles
KW - Western Europe
KW - Europe
KW - Commonwealth of Nations
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - Great Britain
KW - UK
KW - Britain
KW - i.v. drug abusers
KW - i.v. drug users
KW - intravenous drug users
KW - United Kingdom
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093222806&site=ehost-live&scope=site
UR - http://journals.cambridge.org/action/displayJournal?jid=HYG
UR - email: noel.craine@nphs.wales.nhs.uk
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for skin cancer: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 3
SP - 188
EP - 192
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093035024. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 12 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2001 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for skin cancer. Methods: To update its recommendation, the USPSTF reviewed evidence published since 2001 on studies on screening effectiveness, the stage of detection by screening, and the accuracy of whole-body examination by primary care clinicians and self-examination by patients. Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for skin cancer by primary care clinicians or by patient skin self-examination. (I statement).
KW - disease prevention
KW - guidelines
KW - health services
KW - human diseases
KW - neoplasms
KW - screening
KW - skin diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - dermatoses
KW - recommendations
KW - screening tests
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093035024&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for skin cancer: an update of the evidence for the U.S. Preventive Services Task Force.
AU - Wolff, T.
AU - Tai, E.
AU - Miller, T.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 3
SP - 194
EP - 198
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Wolff, T.: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093035025. Publication Type: Journal Article. Language: English. Number of References: 26 ref. Subject Subsets: Public Health
N2 - Background: Skin cancer is the most commonly diagnosed cancer in the United States. The majority of skin cancer is nonmelanoma cancer, either basal cell cancer or squamous cell cancer. The incidence of both melanoma and nonmelanoma skin cancer has been increasing over the past 3 decades. In 2001, the U.S. Preventive Services Task Force (USPSTF) found insufficient evidence to recommend for or against routine screening for skin cancer by using whole-body skin examination for early detection of skin cancer. Purpose: To update the evidence of benefits and harms of screening for skin cancer in the general population. Data Sources: MEDLINE and Cochrane Library searches from 1 June 1999 to 9 August 2005 for English-language articles; recent systematic reviews; reference lists of retrieved articles; and expert suggestions. Study Selection: English-language studies were selected to answer the following key question: Does screening in asymptomatic persons with whole-body examination by a primary care clinician or by self-examination reduce morbidity and mortality from skin cancer? Randomized, controlled trials and case-control studies of screening for skin cancer were selected. One author selected English-language studies to answer the following contextual questions: Can screening with whole-body examination by primary care clinicians or by self-examination accurately detect skin cancer? Does screening with whole-body examination or by self-examination detect melanomas at an earlier stage (thinner lesions)? Data Extraction: All studies for the key question were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: No new evidence from controlled studies was found that addressed the benefit of screening for skin cancer with a whole-body examination by a physician. One article of fair quality, which reanalyzed data from a 1996 study identified for the 2001 report for the USPSTF, provides limited but insufficient evidence on the benefit of skin self-examination in the reduction of morbidity and mortality from melanoma. Limitations: Direct evidence linking skin cancer screening to improved health outcomes is lacking. Information is limited on the accuracy of screening by physicians or patients using real patients and lesions. Conclusion: The limited evidence prevents accurate estimation of the benefits of screening for skin cancer in the general primary care population.
KW - disease prevention
KW - guidelines
KW - human diseases
KW - melanoma
KW - neoplasms
KW - screening
KW - skin diseases
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - cancers
KW - dermatoses
KW - recommendations
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093035025&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 6
SP - 396
EP - 404
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093076827. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 12 ref. Registry Number: 50-78-2. Subject Subsets: Public Health
N2 - Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation about the use of aspirin for the prevention of coronary heart disease. Methods: Review of the literature since 2002, focusing on new evidence on the benefits and harms of aspirin for the primary prevention of cardiovascular disease, including myocardial infarction and stroke. The new evidence was reviewed and synthesized according to sex. Recommendations: Encourage men age 45 to 79 years to use aspirin when the potential benefit of a reduction in myocardial infarctions outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Encourage women age 55 to 79 years to use aspirin when the potential benefit of a reduction in ischemic strokes outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Evidence is insufficient to assess the balance of benefits and harms of aspirin for cardiovascular disease prevention in men and women 80 years or older. (I statement) Do not encourage aspirin use for cardiovascular disease prevention in women younger than 55 years and in men younger than 45 years. (D recommendation).
KW - adverse effects
KW - age differences
KW - analgesics
KW - aspirin
KW - cardiovascular diseases
KW - chemoprophylaxis
KW - disease prevention
KW - guidelines
KW - haemorrhage
KW - human diseases
KW - myocardial infarction
KW - reviews
KW - safety
KW - sex differences
KW - stroke
KW - systematic reviews
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - acetylsalicylic acid
KW - adverse reactions
KW - bleeding
KW - heart attack
KW - hemorrhage
KW - pain killers
KW - recommendations
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093076827&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force.
AU - Wolff, T.
AU - Miller, T.
AU - Ko, S.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 6
SP - 405
EP - 410
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Wolff, T.: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093076828. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Registry Number: 50-78-2. Subject Subsets: Public Health
N2 - Background: Coronary heart disease and cerebrovascular disease are leading causes of death in the United States. In 2002, the U.S. Preventive Services Task Force (USPSTF) strongly recommended that clinicians discuss aspirin with adults who are at increased risk for coronary heart disease. Purpose: To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death. Data Sources: MEDLINE and Cochrane Library (search dates, 1 January 2001 to 28 August 2008), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. Study Selection: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD? Does aspirin increase gastrointestinal bleeding or hemorrhagic strokes? Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: New evidence from 1 good-quality RCT, 1 good-quality meta-analysis, and 2 fair-quality subanalyses of RCTs demonstrates that aspirin use reduces the number of CVD events in patients without known CVD. Men in these studies experienced fewer myocardial infarctions and women experienced fewer ischemic strokes. Aspirin does not seem to affect CVD mortality or all-cause mortality in either men or women. The use of aspirin for primary prevention increases the risk for major bleeding events, primarily gastrointestinal bleeding events, in both men and women. Men have an increased risk for hemorrhagic strokes with aspirin use. A new RCT and meta-analysis suggest that the risk for hemorrhagic strokes in women is not statistically significantly increased. Limitations: New evidence on aspirin for the primary prevention of CVD is limited. The dose of aspirin used in the RCTs varied, which prevented the estimation of the most appropriate dose for primary prevention. Several of the RCTs were conducted within populations of health professionals, which potentially limits generalizability. Conclusion: Aspirin reduces the risk for myocardial infarction in men and strokes in women. Aspirin use increases the risk for serious bleeding events.
KW - adverse effects
KW - analgesics
KW - aspirin
KW - cardiovascular diseases
KW - chemoprophylaxis
KW - disease prevention
KW - haemorrhage
KW - human diseases
KW - meta-analysis
KW - mortality
KW - myocardial infarction
KW - randomized controlled trials
KW - reviews
KW - risk
KW - safety
KW - sex differences
KW - stroke
KW - systematic reviews
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - acetylsalicylic acid
KW - adverse reactions
KW - bleeding
KW - death rate
KW - heart attack
KW - hemorrhage
KW - pain killers
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Pharmacology (VV730) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093076828&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Counseling and interventions to prevent tobacco use and tobacco-caused disease in adults and pregnant women: U.S. Preventive Services Task Force reaffirmation recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 8
SP - 551
EP - 555
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093112074. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 7 ref. Subject Subsets: Public Health
N2 - Description: Reaffirmation of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation on counseling to prevent tobacco use. Methods: The USPSTF reviewed new evidence in the U.S. Public Health Service's 2008 clinical practice guideline and determined that the net benefits of tobacco cessation interventions in adults and pregnant women remain well established. Recommendations: Ask all adults about tobacco use and provide tobacco cessation interventions for those who use tobacco products. Ask all pregnant women about tobacco use and provide augmented, pregnancy-tailored counseling for those who smoke.
KW - adults
KW - behaviour modification
KW - guidelines
KW - health hazards
KW - health promotion
KW - individual counseling
KW - pregnancy
KW - smoking cessation
KW - tobacco smoking
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - behavior modification
KW - gestation
KW - recommendations
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093112074&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 9
SP - 626
EP - 631
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093126674. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 23 ref. Registry Number: 59-30-3. Subject Subsets: Public Health; Human Nutrition
N2 - Description: In 1996, the U.S. Preventive Services Task Force (USPSTF) recommended that all women planning or capable of pregnancy take a multivitamin supplement containing folic acid for the prevention of neural tube defects. This recommendation is an update of the 1996 USPSTF recommendation. Methods: The USPSTF reviewed the evidence on folic acid supplementation in women of childbearing age published since the 1996 USPSTF recommendation. The USPSTF did not review the evidence on folic acid food fortification, counseling to increase dietary intake, or screening for neural tube defects. Recommendation: The USPSTF recommends that all women planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid. (Grade A recommendation).
KW - congenital abnormalities
KW - control programmes
KW - disease prevention
KW - folic acid
KW - guidelines
KW - health care
KW - human diseases
KW - neonates
KW - neural tube defects
KW - pregnancy
KW - public health
KW - reviews
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - control programs
KW - folacin
KW - folate
KW - gestation
KW - newborn infants
KW - recommendations
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093126674&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force.
AU - Wolff, T.
AU - Witkop, C. T.
AU - Miller, T.
AU - Syed, S. B.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 9
SP - 632
EP - 639
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Wolff, T.: U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093126675. Publication Type: Journal Article. Language: English. Number of References: 13 ref. Registry Number: 59-30-3. Subject Subsets: Public Health; Human Nutrition
N2 - Background: Neural tube defects (NTDs) are among the most common birth defects in the United States. In 1996, the U.S. Preventive Services Task Force (USPSTF) recommended that all women planning a pregnancy or capable of conception take a supplement containing folic acid to reduce the risk for NTDs. Purpose: To search for new evidence published since 1996 on the benefits and harms of folic acid supplementation for women of childbearing age to prevent neural tube defects in offspring, to inform an updated USPSTF recommendation. Data Sources: MEDLINE and Cochrane Central Register of Controlled Trials searches from January 1995 through December 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. Study Selection: English-language randomized, controlled trials; cohort studies; case-control studies; systematic reviews; and meta-analyses were selected if they provided information on the benefits and harms of folic acid supplementation in women of childbearing age to reduce NTDs in offspring. Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: Four observational studies reported benefit of reduction of risk for NTDs associated with folic acid-containing supplements. Differences in study type and methods prevent the calculation of a summary of the reduction in risk. The one included study on harms reported that the association of twinning with folic acid intake disappeared after adjustment for in vitro fertilization and underreporting of folic acid intake. Limitations: The evidence on dose was limited. No evidence was found on the potential harm of masking vitamin B12 deficiency in women of childbearing age. The search focused on the association of NTDs with supplementation only and therefore does not provide a comprehensive review of the effects of folic acid on all possible outcomes or of the effects of dietary intake of folic acid. Conclusion: New observational evidence supports previous evidence from a randomized, controlled trial that folic acid-containing supplements reduce the risk for NTD-affected pregnancies. The association of folic acid use with twin gestation may be confounded by fertility interventions.
KW - congenital abnormalities
KW - control programmes
KW - disease prevention
KW - folic acid
KW - guidelines
KW - health care
KW - human diseases
KW - neonates
KW - neural tube defects
KW - pregnancy
KW - public health
KW - reviews
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - birth defects
KW - congenital malformations
KW - control programs
KW - folacin
KW - folate
KW - gestation
KW - newborn infants
KW - recommendations
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093126675&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for syphilis infection in pregnancy: U.S. Preventive Services Task Force reaffirmation recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 10
SP - 705
EP - 709
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093147656. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 5 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2004 U.S. Preventive Services Task Force statement about screening for syphilis in pregnancy. Methods: The U.S. Preventive Services Task Force did a targeted literature search for evidence on the benefits of screening, the harms of screening, and the harms of treatment of syphilis with penicillin during pregnancy. Recommendation: Screen all pregnant women for syphilis infection. (Grade A recommendation.).
KW - antibacterial agents
KW - antibiotics
KW - drug therapy
KW - guidelines
KW - human diseases
KW - penicillins
KW - pregnancy
KW - screening
KW - syphilis
KW - women
KW - USA
KW - man
KW - Treponema pallidum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Treponema
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chemotherapy
KW - gestation
KW - recommendations
KW - screening tests
KW - United States of America
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Reproduction and Development (VV060)
KW - Human Sexual and Reproductive Health (VV065) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093147656&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for syphilis infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement.
AU - Wolff, T.
AU - Shelton, E.
AU - Sessions, C.
AU - Miller, T.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 10
SP - 710
EP - 716
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Wolff, T.: U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093147657. Publication Type: Journal Article. Language: English. Number of References: 15 ref. Subject Subsets: Public Health
N2 - Background: In 2004, the U.S. Preventive Services Task Force strongly recommended that clinicians screen all pregnant women for syphilis infection. Purpose: To update the evidence on screening pregnant women for syphilis infection. Data Sources: MEDLINE searches from 1 January 2003 through 31 July 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. Study Selection: English-language studies were selected to answer the following 2 questions: Does screening for syphilis in pregnancy reduce the prevalence of congenital syphilis in neonates? Are there harms of screening for syphilis or harms of treatment with penicillin in pregnancy to women or neonates? Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; and ecologic studies were selected for the potential benefits question. Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; case-control studies; and large case series were selected for the potential harms question. Data Extraction: Information on the study design, selection criteria, demographic characteristics, and clinical outcomes was extracted from each study. Data Synthesis: One study on benefits evaluated the effect before and after the implementation of a universal syphilis screening program for pregnant women and found reductions in rates of congenital syphilis. Two studies on screening accuracy for syphilis reported false-positive rates of less than 1%. One study that used a large insurance claims database reported an incidence of anaphylaxis after oral penicillin of 0.1 per 10000 dispensings. In a study from Hungary, oral penicillin in pregnancy was not associated with orofacial clefts. Limitations: This was a targeted literature search and could have missed small studies on the benefits and harms of screening for syphilis in pregnancy. We did not review evidence on interventions to improve rates of prenatal screening. Conclusion: New evidence from a study of universal screening supports previous evidence on the effectiveness of screening for syphilis in pregnancy to prevent congenital syphilis. Harms include testing and follow-up for false-positive test results and adverse effects from penicillin treatment.
KW - antibacterial agents
KW - antibiotics
KW - congenital infection
KW - disease prevention
KW - drug therapy
KW - fetus
KW - guidelines
KW - human diseases
KW - penicillins
KW - pregnancy
KW - screening
KW - syphilis
KW - women
KW - USA
KW - man
KW - Treponema pallidum
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Treponema
KW - Spirochaetaceae
KW - Spirochaetales
KW - Spirochaetes
KW - Bacteria
KW - prokaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - bacterium
KW - chemotherapy
KW - foetus
KW - gestation
KW - prenatal infection
KW - recommendations
KW - screening tests
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093147657&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for hepatitis B virus infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement.
AU - Lin, K.
AU - Vickery, J.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 150
IS - 12
SP - 874
EP - 876
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Lin, K.: Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20093175265. Publication Type: Journal Article. Language: English. Number of References: 9 ref. Subject Subsets: Public Health
N2 - Background: Screening for hepatitis B virus (HBV) infection in pregnant women to identify newborns who will require prophylaxis against perinatal infection is a well-established, evidence-based standard of current medical practice. In 2004, the U.S. Preventive Services Task Force (USPSTF) recommended universal screening of pregnant women for HBV infection at the first prenatal visit. Purpose: To search for large, high-quality studies related to hepatitis B screening in pregnancy that have been published since the 2004 USPSTF recommendation. Data Sources: English-language studies indexed in PubMed and the Cochrane Database of Systematic Reviews and published between 1 January 2001 and 5 March 2008. Study Selection: For benefits of screening and newborn prophylaxis, we included systematic reviews; meta-analyses; and randomized, controlled trials. For harms of screening, we included systematic reviews; meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases. Abstracts and full articles were independently reviewed for inclusion by both reviewers. Data Extraction: Data on the benefits of screening, including benefits of hepatitis B immune globulin and hepatitis B vaccine prophylaxis of newborns of hepatitis B surface antigen-positive mothers, were extracted by 1 reviewer. Data Synthesis: No new studies met inclusion criteria. A 2006 systematic review of randomized, controlled trials found that newborn prophylaxis reduced perinatal transmission of HBV infection; all relevant trials were published in 1996 or earlier. Limitation: The focused search strategy, which was restricted to English-language articles, may have missed some smaller studies or new research published in languages other than English. Conclusion: No new evidence was found on the benefits or harms of screening for HBV infection in pregnant women. Previously published randomized trials support the 2004 USPSTF recommendation for screening.
KW - disease prevention
KW - disease transmission
KW - guidelines
KW - hepatitis B
KW - human diseases
KW - immunization
KW - mothers
KW - neonates
KW - pregnancy
KW - prenatal screening
KW - prophylaxis
KW - risk reduction
KW - vaccination
KW - vaccines
KW - viral antigens
KW - women
KW - USA
KW - Hepatitis B virus
KW - man
KW - Hepadnaviridae
KW - DNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - antenatal screening
KW - gestation
KW - Hepatitis B surface antigens
KW - immune sensitization
KW - newborn infants
KW - recommendations
KW - United States of America
KW - Host Resistance and Immunity (HH600)
KW - Human Reproduction and Development (VV060)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093175265&site=ehost-live&scope=site
UR - email: Kenneth.Lin@ahrq.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force Recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 151
IS - 7
SP - 474
EP - 482
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093291064. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 40 ref. Registry Number: 9007-41-4, 6027-13-0. Subject Subsets: Public Health
N2 - Description: New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. Methods: Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers of CHD risk: high-sensitivity C-reactive protein, ankle-brachial index, leukocyte count, fasting blood glucose, periodontal disease, carotid intima-media thickness, coronary artery calcification score on electron-beam computed tomography, homocysteine, and lipoprotein(a). The reviews followed a hierarchical approach aimed at determining which factors could practically and definitively reassign persons assessed as intermediate-risk according to their Framingham score to either a high-risk or low-risk strata, and thereby improve outcomes by means of aggressive risk-factor modification in those newly assigned to the high-risk stratum. Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of using the nontraditional risk factors studied to screen asymptomatic men and women with no history of CHD to prevent CHD events. (I statement).
KW - arteries
KW - atherosclerosis
KW - blood pressure
KW - blood sugar
KW - C-reactive protein
KW - guidelines
KW - heart diseases
KW - homocysteine
KW - human diseases
KW - leukocyte count
KW - lipoproteins
KW - periodontal diseases
KW - reviews
KW - risk assessment
KW - risk factors
KW - screening
KW - systematic reviews
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - arteriosclerosis
KW - blood glucose
KW - cell count
KW - coronary diseases
KW - glucose in blood
KW - recommendations
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093291064&site=ehost-live&scope=site
UR - http://www.annals.org/
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009///
VL - 151
IS - 10
SP - 716
EP - 726
CY - Philadelphia; USA
PB - American College of Physicians
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
N1 - Accession Number: 20093333283. Publication Type: Journal Article. Corporate Author: USA, U. S. Preventive Services Task Force Language: English. Number of References: 32 ref. Subject Subsets: Public Health
N2 - Description: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for breast cancer in the general population. Methods: The USPSTF examined the evidence on the efficacy of 5 screening modalities in reducing mortality from breast cancer: film mammography, clinical breast examination, breast self-examination, digital mammography, and magnetic resonance imaging in order to update the 2002 recommendation. To accomplish this update, the USPSTF commissioned 2 studies: (1) a targeted systematic evidence review of 6 selected questions relating to benefits and harms of screening, and (2) a decision analysis that used population modeling techniques to compare the expected health outcomes and resource requirements of starting and ending mammography screening at different ages and using annual versus biennial screening intervals. Recommendations: The USPSTF recommends against routine screening mammography in women aged 40 to 49 years. The decision to start regular, biennial screening mammography before the age of 50 years should be an individual one and take into account patient context, including the patient's values regarding specific benefits and harms. (Grade C recommendation) The USPSTF recommends biennial screening mammography for women between the ages of 50 and 74 years. (Grade B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the additional benefits and harms of screening mammography in women 75 years or older. (I statement) The USPSTF concludes that the current evidence is insufficient to assess the additional benefits and harms of clinical breast examination beyond screening mammography in women 40 years or older. (I statement) The USPSTF recommends against clinicians teaching women how to perform breast self-examination. (Grade D recommendation) The USPSTF concludes that the current evidence is insufficient to assess additional benefits and harms of either digital mammography or magnetic resonance imaging instead of film mammography as screening modalities for breast cancer. (I statement).
KW - age
KW - breast
KW - breast cancer
KW - clinical examination
KW - guidelines
KW - human diseases
KW - magnetic resonance imaging
KW - mammography
KW - neoplasms
KW - radiography
KW - reviews
KW - screening
KW - self care
KW - systematic reviews
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - breasts
KW - cancers
KW - recommendations
KW - screening tests
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093333283&site=ehost-live&scope=site
UR - http://www.annals.org/
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Isolation and characterization of a new mosquito flavivirus, Quang Binh virus, from Vietnam.
AU - Crabtree, M. B.
AU - Nga, P. T.
AU - Miller, B. R.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2009///
VL - 154
IS - 5
SP - 857
EP - 860
CY - Wien; Austria
PB - Springer-Wien
SN - 0304-8608
AD - Crabtree, M. B.: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 3150 Rampart Road, Fort Collins, CO 80521, USA.
N1 - Accession Number: 20093140052. Publication Type: Journal Article. Language: English. Subject Subsets: Tropical Diseases; Medical & Veterinary Entomology
N2 - In recent years, a number of flaviviruses that replicate only in an arthropod host have been discovered and characterized. We describe here the isolation and characterization of a new mosquito-only flavivirus in this group. The virus was isolated from Culex tritaeniorhyncus mosquitoes collected in Vietnam in 2002 and was found to be genetically different from mosquito flaviviruses described previously. We propose the isolate be named Quang Binh virus.
KW - characterization
KW - hosts
KW - isolation
KW - mosquito-borne diseases
KW - new host records
KW - viral diseases
KW - Vietnam
KW - Culex tritaeniorhynchus
KW - Flavivirus
KW - Culex
KW - Culicidae
KW - Diptera
KW - insects
KW - Hexapoda
KW - arthropods
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - APEC countries
KW - ASEAN Countries
KW - Developing Countries
KW - Indochina
KW - South East Asia
KW - Asia
KW - Viet Nam
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Public Health Pests, Vectors and Intermediate Hosts (VV230) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093140052&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/q106074114084411/?p=f80240ff5b0a441c9f3579c54a43178d&pi=13
UR - email: mcrabtree@cdc.gov\meb3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Detection of Aichi virus shedding in a child with enteric and extraintestinal symptoms in Hungary.
AU - Reuter, G.
AU - Boldizsár, Á.
AU - Papp, G.
AU - Pankovics, P.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2009///
VL - 154
IS - 9
SP - 1529
EP - 1532
CY - Wien; Austria
PB - Springer-Wien
SN - 0304-8608
AD - Reuter, G.: Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, 7623 Pecs, Hungary.
N1 - Accession Number: 20093271460. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - Aichi virus, genus Kobuvirus, family Picornaviridae, has been proposed as a causative agent of gastroenteritis in human. Although high seroprevalence has been detected, it has been identified in only a few cases. We report detection of Aichi virus in Hungary. A total of 65 stool samples were tested retrospectively, collected from children with diarrhea, by reverse transcription-polymerase chain reaction. One (1.5%) sample from a 3-year-old girl was positive. Besides diarrhea, fever, purulent conjunctivitis and respiratory symptoms were also present at the same time with virus shedding. The genotype A virus, Kobuvirus/human/Szigetvar-HUN298/2000/Hungary (FJ225407), has 96% nucleotide identity to Aichi virus.
KW - case reports
KW - children
KW - clinical aspects
KW - diagnosis
KW - gastroenteritis
KW - reverse transcriptase PCR
KW - viral diseases
KW - Hungary
KW - Aichi virus
KW - man
KW - Kobuvirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - clinical picture
KW - reverse transcriptase polymerase chain reaction
KW - RT-PCR
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093271460&site=ehost-live&scope=site
UR - http://springerlink.metapress.com/content/l384523854r1746n/?p=4725f2f32bba479a88fe0ea7922428f5&pi=18
UR - email: reuter.gabor@ddr.antsz.hu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of different RT enzyme standards for quantitation of retroviruses using the single-tube fluorescent product-enhanced reverse transcriptase assay.
AU - Ma, Y. K.
AU - Khan, A. S.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2009///
VL - 157
IS - 2
SP - 133
EP - 140
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Ma, Y. K.: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics, Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093136899. Publication Type: Journal Article. Language: English. Number of References: 21 ref. Registry Number: 9068-38-6. Subject Subsets: Public Health
N2 - PCR-based reverse transcriptase (RT) assays are highly sensitive for broad detection of retroviruses. These assays are currently used for demonstrating the absence of retroviral contamination in vaccines and can also be applied to clinical and laboratory research to investigate low-virus replication. A single-tube fluorescent product-enhanced reverse transcriptase assay (STF-PERT) has been published that was highly sensitive for retrovirus detection (<10 virions), with enhanced reproducibility and increased efficiency [Sears, J.F., Khan, A.S., 2003. Single-tube fluorescent product-enhanced reverse transcriptase assay with AmpliWax (STF-PERT) for retrovirus quantitation. J. Virol. Meth. 108, 139-142]. In this report, the step-by-step setup and performance of the STF-PERT assay is described and sensitivity, reproducibility and specificity of the assay reported using three different RTs as standards: avian myeloblastosis virus (AMV) RT, murine leukemia virus (MMLV) RT, and human immunodeficiency virus type 1 (HIV-1) RT. Evaluation of virus stocks showed about 1-2 logs difference in RT detection and retrovirus quantitation with the different RT enzyme standards; in general, virus determination using HIV-1 RT was comparable to using the relevant virus RT.
KW - bioassays
KW - detection
KW - reverse transcriptase
KW - reverse transcriptase PCR
KW - Maryland
KW - USA
KW - Avian myeloblastosis virus
KW - Human immunodeficiency virus 1
KW - Murine leukemia virus
KW - Retroviridae
KW - Alpharetrovirus
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - human immunodeficiency viruses
KW - Lentivirus
KW - Orthoretrovirinae
KW - Gammaretrovirus
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Human immunodeficiency virus type 1
KW - reverse transcriptase polymerase chain reaction
KW - RT-PCR
KW - United States of America
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093136899&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01660934
UR - email: arifa.khan@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - High-throughput real-time PCR for early detection and quantitation of arenavirus Tacaribe.
AU - Grajkowska, L. T.
AU - Pedras-Vasconcelos, J. A.
AU - Sauder, C.
AU - Verthelyi, D.
AU - Puig, M.
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2009///
VL - 159
IS - 2
SP - 239
EP - 243
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0166-0934
AD - Grajkowska, L. T.: Division of Therapeutic Proteins, Office of Biotechnology Products, CDER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093186197. Publication Type: Journal Article. Language: English. Number of References: 20 ref. Registry Number: 63231-63-0. Subject Subsets: Public Health
N2 - Arenaviruses merit significant attention both as causative agents of endemic hemorrhagic fevers and as model systems to study the immune response to acute and persistent viral infections. Development of highly sensitive quantitative screening methods to detect arenavirus is critical for early diagnosis of patients, to screen the rodent population in endemic areas, and as a research tool to confirm effective tissue clearance during the development of anti-viral strategies. This study describes a novel sensitive and reproducible method to quantify prototypic new world arenavirus Tacaribe RNA in cell cultures and tissues using a real-time TaqMan PCR-based detection system. The method has a sensitivity of 100 RNA copies per 200 ng of total RNA, making it 2 logs more sensitive than the currently utilized TCID50 method, and a linear range from 102 to 109 copies/reaction. The qRT-PCR method is high-throughput and screening can be achieved in <2 h allowing for diagnosis of infected patients before the onset of symptoms. This new method is a powerful tool to screen populations for infection and monitor the clearance achieved by available therapies, and serves as a model diagnostic tool for other arenaviruses.
KW - cell cultures
KW - detection
KW - diagnosis
KW - diagnostic techniques
KW - human diseases
KW - polymerase chain reaction
KW - RNA
KW - viral diseases
KW - Maryland
KW - USA
KW - Arenavirus
KW - man
KW - Arenaviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - PCR
KW - ribonucleic acid
KW - United States of America
KW - viral infections
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093186197&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/01660934
UR - email: Daniela.verthelyi@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Radon exposure and mortality among white and American Indian uranium miners: an update of the Colorado Plateau cohort.
AU - Schubauer-Berigan, M. K.
AU - Daniels, R. D.
AU - Pinkerton, L. E.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009///
VL - 169
IS - 6
SP - 718
EP - 730
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Schubauer-Berigan, M. K.: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop R15, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093117246. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 10043-92-2. Subject Subsets: Public Health
N2 - Studies of uranium miners on the US Colorado Plateau have identified associations between exposure to radon progeny and risk of lung cancer. This study added 15 years of mortality follow-up for the 4,137 miners (primarily white or American Indian) in the Colorado Plateau cohort. The cohort experienced 209 new lung cancer deaths. For white miners, the standardized mortality ratio for lung cancer compared with the regional population was 3.99 (95% confidence interval: 3.43, 4.62) for the period 1991-2005. For American Indian miners, the lung cancer standardized mortality ratio was 3.27 (95% confidence interval: 2.19, 4.73). These standardized mortality ratios have not declined substantially since the 1980s. Internally standardized rate ratios by radon exposure category over the entire follow-up period are similar to those based on earlier follow-up, although estimates within smoking categories demonstrated improved precision. The apparent interaction between radon and smoking in causing lung cancer remains submultiplicative but greater than additive. Mortality rates from silicosis remain highly elevated in the cohort. Elevated mortality rates were observed from interstitial pulmonary fibrosis, multiple myeloma, and non-Hodgkin lymphoma. Significant trends were observed with increased radon exposure in silicosis and pulmonary fibrosis mortality and in the incidence of diabetes-related end-stage renal disease among white miners.
KW - American Indians
KW - disease prevalence
KW - epidemiology
KW - exposure
KW - fibrosis
KW - follow up
KW - human diseases
KW - incidence
KW - indigenous people
KW - kidney diseases
KW - kidneys
KW - lung cancer
KW - lungs
KW - lymphoma
KW - miners
KW - mortality
KW - myeloma
KW - neoplasms
KW - non-Hodgkin's lymphoma
KW - occupational disorders
KW - progeny
KW - radon
KW - silicosis
KW - Colorado
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Great Plains States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - Mountain States of USA
KW - Western States of USA
KW - cancers
KW - death rate
KW - kidney disorders
KW - mortality rates
KW - multiple myeloma
KW - nephropathy
KW - renal diseases
KW - United States of America
KW - Human Health and the Environment (VV500)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Health Services (UU350)
KW - Demography (UU200)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093117246&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: zcg3@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Use of nonsteroidal antiinflammatory agents and incidence of ovarian cancer in 2 large prospective cohorts.
AU - Pinheiro, S. P.
AU - Tworoger, S. S.
AU - Cramer, D. W.
AU - Rosner, B. A.
AU - Hankinson, S. E.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009///
VL - 169
IS - 11
SP - 1378
EP - 1387
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Pinheiro, S. P.: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Room 2471, Silver Spring, MD 20993, USA.
N1 - Accession Number: 20093167779. Publication Type: Journal Article. Language: English. Number of References: 52 ref. Registry Number: 103-90-2, 50-78-2. Subject Subsets: Public Health
N2 - Epidemiologic data on the association between nonsteroidal antiinflammatory drugs (NSAIDs) and ovarian cancer risk have been inconsistent. The authors prospectively examined the association between regular use of aspirin and nonaspirin NSAIDs and ovarian cancer incidence among 197,486 participants of the Nurses' Health Study (NHS) and the Nurses' Health Study-II (NHS-II) over 24 and 16 years of follow-up, respectively. Information on aspirin was initially assessed in 1980 (NHS) and 1989 (NHS-II) and on nonaspirin NSAIDs and acetaminophen in 1990 (NHS) and 1989 (NHS-II) and updated throughout follow-up. The authors used Cox proportional hazards models adjusting for ovarian cancer risk factors. A total of 666 confirmed cases of epithelial ovarian cancer were identified over 2,790,986 person-years of follow-up. The hazard ratios associated with regular use of aspirin, nonaspirin NSAIDs, and acetaminophen were 1.11 (95% confidence interval (CI): 0.92, 1.33), 0.81 (95% CI: 0.64, 1.01), and 1.14 (95% CI: 0.92, 1.43), respectively. The authors did not observe a dose-response relation with increased frequency or duration of regular use of any of these medications and ovarian cancer incidence. The results did not differ substantially by tumor histology. In this large prospective study, the authors found no compelling evidence to support an association between regular use of aspirin, nonaspirin NSAIDs, or acetaminophen and ovarian cancer incidence.
KW - acetaminophen
KW - antiinflammatory agents
KW - aspirin
KW - disease prevalence
KW - epidemiology
KW - follow up
KW - hazards
KW - health services
KW - histology
KW - incidence
KW - neoplasms
KW - non-steroidal antiinflammatory agents
KW - risk factors
KW - surveys
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - acetylsalicylic acid
KW - cancers
KW - NSAIDS
KW - paracetamol
KW - Pesticides and Drugs (General) (HH400)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Health Economics (EE118) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093167779&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: spinheir@hsph.harvard.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupation as socioeconomic status or environmental exposure? A survey of practice among population-based cardiovascular studies in the United States.
AU - MacDonald, L. A.
AU - Cohen, A.
AU - Baron, S.
AU - Burchfiel, C. M.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009///
VL - 169
IS - 12
SP - 1411
EP - 1421
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - MacDonald, L. A.: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati, OH 45226-1998, USA.
N1 - Accession Number: 20093189909. Publication Type: Journal Article. Language: English. Number of References: 129 ref. Subject Subsets: Public Health
N2 - Decisions about how occupation is used in epidemiologic research can affect conclusions about the importance of socioeconomic and environmental factors in explaining disparities for outcomes such as cardiovascular disease. A review of practices in the collection and use of occupational data was conducted among population-based cardiovascular studies in the United States. Studies were identified for review from the National Heart, Lung, and Blood Institute website and the biomedical database, Computer Retrieval of Information on Scientific Projects, by use of selected criteria. Data collection instruments and study publications were retrieved and reviewed for 30 of 33 studies (91%). Most of the studies (83%) collected at least descriptive occupational data, and more than half (60%) collected data on workplace hazards. The reviewed studies produced 80 publications in which occupational data were used in analyses, most often as an indicator of socioeconomic status. Authors rarely acknowledged known conceptual and empirical links among socioeconomic status, employment stability, and working conditions. Underutilization of data on workplace conditions was found. Existing data could be used more effectively to examine the contribution of work-related social and environmental conditions to the development of modifiable cardiovascular disease through multiple pathways.
KW - cardiovascular diseases
KW - cardiovascular system
KW - collections
KW - data collection
KW - environment
KW - environmental factors
KW - environmental health
KW - epidemiology
KW - exposure
KW - hazards
KW - heart
KW - human diseases
KW - lungs
KW - public health
KW - publications
KW - socioeconomic status
KW - socioeconomics
KW - surveys
KW - work places
KW - working conditions
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - circulatory system
KW - data logging
KW - practices
KW - socioeconomic aspects
KW - United States of America
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Health and the Environment (VV500)
KW - Health Services (UU350)
KW - Social Psychology and Social Anthropology (UU485) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Social Sciences (General) (UU000)
KW - Human Health and Hygiene (General) (VV000) (Revised June 2002) [formerly Human Health and Hygiene (General)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093189909&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: lmacdonald@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Exposure to farm crops, livestock, and farm tasks and risk of glioma: the Upper Midwest Health Study.
AU - Ruder, A. M.
AU - Carreón, T.
AU - Butler, M. A.
AU - Calvert, G. M.
AU - Davis-King, K. E.
AU - Waters, M. A.
AU - Schulte, P. A.
AU - Mandel, J. S.
AU - Morton, R. F.
AU - Reding, D. J.
AU - Rosenman, K. D.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009///
VL - 169
IS - 12
SP - 1479
EP - 1491
CY - Cary; USA
PB - Oxford University Press
SN - 0002-9262
AD - Ruder, A. M.: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-16, Cincinnati, OH 45226, USA.
N1 - Accession Number: 20093189916. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Public Health; Pig Science; Animal Breeding; Horticultural Science; Veterinary Science; Soyabeans
N2 - Some studies of brain cancer have found an excess risk for farmers. The National Institute for Occupational Safety and Health previously found no increased glioma risk for ever (vs. never) being exposed to pesticides on a farm among 798 cases and 1,175 population-based controls (adult (ages 18-80 years) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin). For this analysis (1995-1998), 288 cases and 474 controls (or their proxies) who had lived on farms at age 18 years or after were asked about exposure to crops, livestock, and farm tasks. Logistic regression was used to calculate odds ratios adjusted for age, age group, sex, state, and education. Never immediately washing up (adjusted odds ratio (OR)=3.08, 95% confidence interval (CI): 1.78, 5.34) or changing clothes (OR=2.84, 95% CI: 1.04, 7.78) after applying pesticides was associated with increased glioma risk. Living on a farm on which corn, oats, soybeans, or hogs were raised was associated with decreased risk (corn - OR=0.37, 95% CI: 0.20, 0.69; oats - OR=0.63, 95% CI: 0.40, 1.00; soybeans - OR=0.69, 95% CI: 0.48, 0.98; hogs - OR=0.63, 95% CI: 0.43, 0.93). Negative associations may be due to chance or a "healthy farmer" effect. Farmers' increased risk of glioma may be due to work practices, other activities, or an inverse association with allergies (reported by other investigators).
KW - allergies
KW - brain
KW - clothing
KW - education
KW - epidemiology
KW - exposure
KW - farmers
KW - farms
KW - human diseases
KW - livestock
KW - neoplasms
KW - oats
KW - pesticide residues
KW - pesticides
KW - safety
KW - safety at work
KW - soyabeans
KW - Iowa
KW - Michigan
KW - Minnesota
KW - USA
KW - Wisconsin
KW - Avena sativa
KW - Glycine (Fabaceae)
KW - man
KW - pigs
KW - Avena
KW - Poaceae
KW - Cyperales
KW - monocotyledons
KW - angiosperms
KW - Spermatophyta
KW - plants
KW - eukaryotes
KW - Papilionoideae
KW - Fabaceae
KW - Fabales
KW - dicotyledons
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Artiodactyla
KW - Corn Belt States of USA
KW - North Central States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - West North Central States of USA
KW - East North Central States of USA
KW - Lake States of USA
KW - apparel
KW - cancers
KW - cerebrum
KW - clothes
KW - hogs
KW - occupational safety
KW - soybeans
KW - swine
KW - United States of America
KW - Animal Immunology (LL650) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Education, Extension, Information and Training (General) (CC000)
KW - Human Health and the Environment (VV500)
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Occupational Health and Safety (VV900)
KW - Horticultural Crops (FF003) (New March 2000)
KW - Field Crops (FF005) (New March 2000)
KW - Meat Producing Animals (LL120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093189916&site=ehost-live&scope=site
UR - http://aje.oupjournals.org/
UR - email: amr2@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Educational preferences and outcomes from suicide prevention training in the Veterans Health Administration: one-year follow-up with healthcare employees in Upstate New York.
AU - Matthieu, M. M.
AU - Chen, Y. F.
AU - Schohn, M.
AU - Lantinga, L. J.
AU - Knox, K. L.
JO - Military Medicine
JF - Military Medicine
Y1 - 2009///
VL - 174
IS - 11
SP - 1123
EP - 1131
CY - Bethesda; USA
PB - Association of Military Surgeons of the US
SN - 0026-4075
AD - Matthieu, M. M.: Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, One Brookings Drive, Campus Box 1196, St. Louis, MO 63130, USA.
N1 - Accession Number: 20093346865. Publication Type: Journal Article. Language: English. Subject Subsets: Public Health
N2 - This study identifies training outcomes and educational preferences of employees who work within the Veterans Health Administration (VHA). Using a longitudinal pre- postsurvey design, 71 employees from one geographic region of VHA healthcare facilities participated in an evaluation of a brief standardized gatekeeper program and a needs assessment on training preferences for suicide and suicide prevention. Results indicate significant differences in knowledge and self-efficacy from pre to post (p<0.001), although only self-efficacy remained significant at 1 year follow-up, (M=3.01; SD=0.87) as compared to pretraining (M=2.50, SD=1.05) (t=-5.64, p<0.001). At post-training, 90% of the participants were willing to learn more about suicide, with 88% willing to spend more than 1 hour in future training activities on more advanced topics. This training program can increase the knowledge and abilities of VHA staff to engage, identify, and refer veterans at risk for suicide to appropriate care.
KW - abnormal behaviour
KW - behaviour
KW - behaviour disorders
KW - disease prevention
KW - health education
KW - human diseases
KW - mental disorders
KW - suicide
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - abnormal behavior
KW - behavior
KW - behavior disorders
KW - deviant behaviour
KW - mental illness
KW - United States of America
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093346865&site=ehost-live&scope=site
UR - http://www.ingentaconnect.com/content/amsus/zmm/2009/00000174/00000011/art00014
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis.
AU - Selvapandiyan, A.
AU - Dey, R.
AU - Nylen, S.
AU - Duncan, R.
AU - Sacks, D.
AU - Nakhasi, H. L.
JO - Journal of Immunology
JF - Journal of Immunology
Y1 - 2009///
VL - 183
IS - 3
SP - 1813
EP - 1820
CY - Bethesda; USA
PB - American Association of Immunologists
SN - 0022-1767
AD - Selvapandiyan, A.: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093256433. Publication Type: Journal Article. Language: English. Number of References: 42 ref. Subject Subsets: Veterinary Science; Protozoology
N2 - No vaccine is currently available for visceral leishmaniasis (VL) caused by Leishmania donovani. This study addresses whether a live attenuated centrin gene-deleted L. donovani (LdCen1-/-) parasite can persist and be both safe and protective in animals. LdCen1-/- has a defect in amastigote replication both in vitro and ex vivo in human macrophages. Safety was shown by the lack of parasites in spleen and liver in susceptible BALB/c mice, immune compromised SCID mice, and human VL model hamsters 10 wk after infection. Mice immunized with LdCen1-/- showed early clearance of virulent parasite challenge not seen in mice immunized with heat killed parasites. Upon virulent challenge, the immunized mice displayed in the CD4+ T cell population a significant increase of single and multiple cytokine (IFN-γ, IL-2, and TNF) producing cells and IFN-γ/IL10 ratio. Immunized mice also showed increased IgG2a immunoglobulins and NO production in macrophages. These features indicated a protective Th1-type immune response. The Th1 response correlated with a significantly reduced parasite burden in the spleen and no parasites in the liver compared with naive mice 10 wk post challenge. Protection was observed, when challenged even after 16 wk post immunization, signifying a sustained immunity. Protection by immunization with attenuated parasites was also seen in hamsters. Immunization with LdCen1-/- also cross-protected mice against infection with L. braziliensis that causes mucocutaneous leishmaniasis. Results indicate that LdCen1-/- can be a safe and effective vaccine candidate against VL as well as mucocutaneous leishmaniasis causing parasites.
KW - CD4+ lymphocytes
KW - immune response
KW - immunity
KW - immunization
KW - live vaccines
KW - liver
KW - post kala azar dermal leishmaniasis
KW - spleen
KW - vaccination
KW - Leishmania donovani
KW - mice
KW - Leishmania
KW - Trypanosomatidae
KW - Kinetoplastida
KW - Sarcomastigophora
KW - Protozoa
KW - invertebrates
KW - animals
KW - eukaryotes
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - attenuated vaccines
KW - CD4+ cells
KW - immune sensitization
KW - immunity reactions
KW - immunological reactions
KW - T4 lymphocytes
KW - Host Resistance and Immunity (HH600)
KW - Animal Immunology (LL650) (New March 2000)
KW - Protozoan, Helminth, Mollusc and Arthropod Parasites of Animals (LL822) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093256433&site=ehost-live&scope=site
UR - http://www.jimmunol.org/
UR - email: hira.nakhasi@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.
AU - Scheri, R. C.
AU - Lee JunGa
AU - Barofsky, D. F.
AU - Curtis, L. R.
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009///
VL - 191
IS - 1
SP - 20
EP - 25
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0378-4274
AD - Scheri, R. C.: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093335677. Publication Type: Journal Article. Language: English. Registry Number: 143-50-0, 57-88-5.
N2 - Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B type I (SR-BI) of the sinusoidal surface. A variety of tissues express scavenger receptor class B type II (SR-BII) and this protein was identified as a splice variant from the SR-BI gene. Although the function of SR-BII has not been elucidated it may play a role in CH homeostasis and trafficking distinctly different than SR-BI. Western blotting demonstrated that a single dose of CD promoted subcellular distribution of SR-BII to murine hepatic microsomes about 2.2-fold when compared to controls without effect on liver crude membrane SR-BII content. This was consistent with increased vesicular CH trafficking. Relative quantification of hepatic cytosolic proteins in a fraction that sequestered [14C]CH by mass spectrometry (MS) indicated no role for cytosolic CH binding proteins in CD altered CH homeostasis. Western blotting verified no effect of CD on liver fatty acid-binding protein (L-FABP) in cytosol. MS detected a statistically significant increase in myosin-9, which was also consistent with increased vesicular trafficking.
KW - animal experiments
KW - animal models
KW - cell structure
KW - chlordecone
KW - cholesterol
KW - cytosol
KW - disease models
KW - human diseases
KW - laboratory animals
KW - lipid metabolism
KW - liver
KW - liver cells
KW - liver diseases
KW - organochlorine pesticides
KW - mice
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - animal research
KW - fat metabolism
KW - hepatocytes
KW - hepatotoxicity
KW - organic chlorine pesticides
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093335677&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-4WYDN0R-2&_user=10&_coverDate=12%2F01%2F2009&_rdoc=6&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235177%232009%23998089998%231553249%23FLA%23display%23Volume)&_cdi=5177&_sort=d&_docanchor=&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=749cacb0835a5dae9d6f6d416e8b6aca
UR - email: larry.curtis@oregonstate.edu
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection.
AU - Reed, J. L.
AU - Welliver, T. P.
AU - Sims, G. P.
AU - McKinney, L.
AU - Velozo, L.
AU - Avendano, L.
AU - Hintz, K.
AU - Luma, J.
AU - Coyle, A. J.
AU - Welliver, R. C., Sr.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009///
VL - 199
IS - 8
SP - 1128
EP - 1138
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Reed, J. L.: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
N1 - Accession Number: 20093119139. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Subject Subsets: Public Health
N2 - Antiviral antibody production during respiratory syncytial virus (RSV) infection in infants is poorly understood. To characterize local B lymphocyte responses, lung tissue and secretions from infants with RSV bronchiolitis were analyzed for innate B cell-stimulating factors and antiviral antibodies. In lung tissues of infants with fatal RSV bronchiolitis, CD20+ lymphocytes and IgM-positive, IgG-positive, and IgA-positive plasma cells were prominent but CD4+ T lymphocytes were not. Type I interferon-induced proteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), were colocalized in infected epithelium. In nasopharyngeal secretions from infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were detected at presentation and correlated with BAFF and APRIL levels. Expression of APRIL and antiviral antibodies of IgA and IgM but not IgG isotype predicted better oxygen saturation. We conclude that B lymphocyte-stimulating factors derived from infected epithelium are primary determinants of the mucosal antibody response in infant RSV bronchiolitis.
KW - antibodies
KW - B lymphocytes
KW - bronchiolitis
KW - human diseases
KW - immune response
KW - natural immunity
KW - plasma cells
KW - T lymphocytes
KW - viral diseases
KW - USA
KW - Human respiratory syncytial virus
KW - man
KW - Pneumovirus
KW - Paramyxoviridae
KW - Mononegavirales
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - Pneumovirinae
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - B cells
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - United States of America
KW - viral infections
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093119139&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/597386
UR - email: jennifer.reed@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of the pathogenesis of decreasing CD4+ T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy.
AU - Nies-Kraske, E.
AU - Schacker, T. W.
AU - Condoluci, D.
AU - Orenstein, J.
AU - Brenchley, J.
AU - Fox, C.
AU - Daucher, M.
AU - Dewar, R.
AU - Urban, E.
AU - Hill, B.
AU - Guenaga, J.
AU - Hoover, S.
AU - Maldarelli, F.
AU - Hallahan, C. W.
AU - Horn, J.
AU - Kottilil, S.
AU - Chun, T. W.
AU - Folino, M.
AU - Palmer, S.
AU - Wiegand, A.
AU - O'Shea, M. A.
AU - Metcalf, J. A.
AU - Douek, D. C.
AU - Coffin, J.
AU - Haase, A.
AU - Fauci, A. S. (et al)
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009///
VL - 199
IS - 11
SP - 1648
EP - 1656
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Nies-Kraske, E.: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093160129. Publication Type: Journal Article. Language: English. Number of References: 50 ref. Registry Number: 69655-05-6, 147127-20-6. Subject Subsets: Public Health
N2 - Most human immunodeficiency virus (HIV)-infected individuals experience increases in peripheral CD4+ T cell counts with suppressive antiretroviral therapy (ART) that achieves plasma HIV RNA levels that are less than the limit of detection. However, some individuals experience decreasing CD4+ T cell counts despite suppression of plasma viremia. We evaluated 4 patients with a history of CD4+ T cell decline despite successfully suppressive ART, from a median of 719 cells/mm3 (range, 360-1141 cells/mm3) to 227 cells/mm3 (range, 174-311 cells/mm3) over a period of 18-24 months; 3 of the patients were receiving tenofovir and didanosine, which may have contributed to this decrease. There was no evidence of HIV replication, nor of antiretroviral drug resistance in the blood or lymphoid tissue, or increased proliferation or decreased thymic production of naive CD4+ T cells. All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells.
KW - antiviral agents
KW - CD4+ lymphocytes
KW - didanosine
KW - drug therapy
KW - HIV infections
KW - human diseases
KW - Human immunodeficiency viruses
KW - immune response
KW - pathogenesis
KW - T lymphocytes
KW - tenofovir
KW - man
KW - Lentivirus
KW - Orthoretrovirinae
KW - Retroviridae
KW - RNA Reverse Transcribing Viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antiretroviral therapy
KW - CD4+ cells
KW - chemotherapy
KW - dideoxyinosine
KW - human immunodeficiency virus infections
KW - immunity reactions
KW - immunological reactions
KW - T cells
KW - T4 lymphocytes
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093160129&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/598980
UR - email: dybulmr@state.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Occupational factors and risk of preterm birth in nurses.
AU - Lawson, C. C.
AU - Whelan, E. A.
AU - Hibert, E. N.
AU - Grajewski, B.
AU - Spiegelman, D.
AU - Rich-Edwards, J. W.
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
Y1 - 2009///
VL - 200
IS - 1
SP - 51.e1
EP - 51.e8
CY - St Louis; USA
PB - Mosby Inc.
SN - 0002-9378
AD - Lawson, C. C.: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA.
N1 - Accession Number: 20093027327. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - Objective: We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II. Study Design: Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity. Results: Part-time work (≤20 hours a week) was associated with a lower risk of preterm birth [RR, 0.7; 95% confidence interval [CI], 0.6-0.9]. Working nights was associated only with early preterm birth (<32 weeks of gestation) (RR, 3.0; 95% CI, 1.4-6.2). Although based on only 11 exposed preterm cases, self-reported exposure to sterilizing agents was associated with an increased risk (RR, 1.9; 95% CI, 1.1-3.4). Conclusion: These data suggest that night work may be related to early but not late preterm birth, whereas physically demanding work did not strongly predict risk.
KW - human diseases
KW - nurses
KW - occupational health
KW - pregnancy
KW - pregnancy complications
KW - risk assessment
KW - risk factors
KW - women
KW - USA
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - gestation
KW - United States of America
KW - Human Reproduction and Development (VV060)
KW - Occupational Health and Safety (VV900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093027327&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9P-4TT715N-8&_user=6686535&_coverDate=01%2F31%2F2009&_rdoc=14&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236688%232009%23997999998%23799364%23FLA%23display%23Volume)&_cdi=6688&_sort=d&_docanchor=&_ct=47&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=0644df5f8732d17f4e7bd89cb1743765
UR - email: clawson@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Trends in the epidemiology of human G1P[8] rotaviruses: a Hungarian study.
AU - Bányai, K.
AU - Gentsch, J. R.
AU - Martella, V.
AU - Bogdán, Á.
AU - Havasi, V.
AU - Kisfali, P.
AU - Szabó, A.
AU - Mihály, I.
AU - Molnár, P.
AU - Melegh, B.
AU - Szücs, G.
T3 - Special Issue: Global rotavirus surveillance: Preparing for the introduction of rotavirus vaccines.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009///
VL - 200
IS - s1
SP - S222
EP - S227
CY - Chicago; USA
PB - University of Chicago Press
SN - 0022-1899
AD - Bányai, K.: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary.
N1 - Accession Number: 20093315536. Publication Type: Journal Article. Note: Special Issue: Global rotavirus surveillance: Preparing for the introduction of rotavirus vaccines. Language: English. Number of References: 19 ref. Subject Subsets: Public Health
N2 - Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents.
KW - antigens
KW - children
KW - diarrhoea
KW - disease incidence
KW - disease prevalence
KW - disease surveys
KW - epidemiological surveys
KW - epidemiology
KW - gastrointestinal diseases
KW - genotypes
KW - human diseases
KW - viral diseases
KW - Hungary
KW - man
KW - Rotavirus
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Reoviridae
KW - dsRNA viruses
KW - RNA viruses
KW - viruses
KW - Central Europe
KW - Europe
KW - Developed Countries
KW - European Union Countries
KW - OECD Countries
KW - antigenicity
KW - diarrhea
KW - disease surveillance
KW - immunogens
KW - scouring
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093315536&site=ehost-live&scope=site
UR - http://www.journals.uchicago.edu/doi/full/10.1086/605052
UR - email: bkrota@hotmail.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water.
AU - Bowyer, J. F.
AU - Latendresse, J. R.
AU - Delongchamp, R. R.
AU - Warbritton, A. R.
AU - Thomas, M.
AU - Divine, B.
AU - Doerge, D. R.
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
Y1 - 2009///
VL - 240
IS - 3
SP - 401
EP - 411
CY - Orlando; USA
PB - Elsevier Inc
SN - 0041-008X
AD - Bowyer, J. F.: US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093315479. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - A study was undertaken to determine whether alterations in the gene expression or overt histological signs of neurotoxicity in selected regions of the forebrain might occur from acrylamide exposure via drinking water. Gene expression at the mRNA level was evaluated by cDNA array and/or RT-PCR analysis in the striatum, substantia nigra and parietal cortex of rat after a 2-week acrylamide exposure. The highest dose tested (maximally tolerated) of approximately 44 mg/kg/day resulted in a significant decreased body weight, sluggishness, and locomotor activity reduction. These physiological effects were not accompanied by prominent changes in gene expression in the forebrain. All the expression changes seen in the 1200 genes that were evaluated in the three brain regions were ≤1.5-fold, and most not significant. Very few, if any, statistically significant changes were seen in mRNA levels of the more than 50 genes directly related to the cholinergic, noradrenergic, GABAergic or glutamatergic neurotransmitter systems in the striatum, substantia nigra or parietal cortex. All the expression changes observed in genes related to dopaminergic function were less than 1.5-fold and not statistically significant and the 5HT1b receptor was the only serotonin-related gene affected. Therefore, gene expression changes were few and modest in basal ganglia and sensory cortex at a time when the behavioral manifestations of acrylamide toxicity had become prominent. No histological evidence of axonal, dendritic or neuronal cell body damage was found in the forebrain due to the acrylamide exposure. As well, microglial activation was not present. These findings are consistent with the absence of expression changes in genes related to changes in neuroinflammation or neurotoxicity. Over all, these data suggest that oral ingestion of acrylamide in drinking water or food, even at maximally tolerable levels, induced neither marked changes in gene expression nor neurotoxicity in the motor and somatosensory areas of the central nervous system.
KW - acrylamides
KW - animal models
KW - brain
KW - central nervous system
KW - cerebral cortex
KW - correlation
KW - gene expression
KW - histopathology
KW - inflammation
KW - laboratory animals
KW - neurotoxicity
KW - statistical analysis
KW - toxicity
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cerebrum
KW - CNS
KW - statistical methods
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093315479&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4WXSJXG-3&_user=10&_coverDate=11%2F01%2F2009&_rdoc=11&_fmt=high&_orig=browse&_srch=doc-info(%23toc%237159%232009%23997599996%231528602%23FLA%23display%23Volume)&_cdi=7159&_sort=d&_docanchor=&_ct=15&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=14d5350f29b062f39a8d30f8cd0ea533
UR - email: john.bowyer@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Analytical capabilities of anticoincidence INAA for biological materials.
AU - Anderson, D. L.
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
Y1 - 2009///
VL - 282
IS - 1
SP - 75
EP - 79
CY - Dordrecht; Netherlands
PB - Springer
SN - 0236-5731
AD - Anderson, D. L.: Chemical Contaminants Branch (HFS-716), Office of Regulatory Science, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093343945. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 7440-38-2, 7726-95-6, 9004-34-6, 7439-97-6, 7782-49-2. Subject Subsets: Human Nutrition
N2 - Sensitivities and limits of detection (LODs) for 39 elements were determined for cellulose filters, foods, and biological reference materials by anticoincidence instrumental neutron activation analysis. Compton background reduction improved many LODs by about a factor of 2, but increased LODs for elements whose radioisotopes decay with cascading γ-rays. As and Hg analyses were aided by reduction of Br and Se photopeak intensities, respectively. LODs of 0.03-0.8 µg/kg were achieved for 16 elements in cellulose filters. Typical biological material and food LODs were higher by factors of about 10-600.
KW - arsenic
KW - bromine
KW - cellulose
KW - filters
KW - foods
KW - mercury
KW - neutron activation analysis
KW - selenium
KW - trace elements
KW - microelements
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Human Toxicology and Poisoning (VV810) (New March 2000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093343945&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/bxk862n5n7221705/?p=6963b48e653948a7842eec90e89b247a&pi=16
UR - email: david.anderson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Screening of foods and related products for toxic elements with a portable X-ray tube analyzer.
AU - Anderson, D. L.
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
Y1 - 2009///
VL - 282
IS - 2
SP - 415
EP - 418
CY - Dordrecht; Netherlands
PB - Springer
SN - 0236-5731
AD - Anderson, D. L.: Chemical Contaminants Branch (HFS-716), Office of Regulatory Science, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.
N1 - Accession Number: 20093358584. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 7440-38-2, 7440-47-3, 7440-50-8, 7439-92-1. Subject Subsets: Human Nutrition
N2 - Capabilities of a portable X-ray tube-based analyzer were evaluated for screening foods, thin films, and ceramic glazes for toxic elements. A beverage spiked with Cr, Cu, and As and cocoa powder spiked with As and Pb could easily be distinguished from unadulterated products when analyzed through their original container walls. With calibration, results for thin films and ceramic glazes yielded accurate Pb results. Limits of detection (LODs) were 0.2-15 and 15 µg cm-2, respectively, for Pb and Cd in thin films and about 2 µg cm-2 for Pb in glazes. With analysis times of 0.5-1 min, sensitivities and LODs were superior to those obtained with radioisotopic X-ray fluorescence analysis.
KW - adulterants
KW - adulteration
KW - arsenic
KW - beverages
KW - chromium
KW - cocoa products
KW - copper
KW - food contamination
KW - foods
KW - lead
KW - methodology
KW - drinks
KW - food contaminants
KW - methods
KW - Crop Produce (QQ050)
KW - Other Produce (QQ070)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093358584&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/x8707815n8037530/?p=2f25265b1051497da86bcde6871e054a&pi=17
UR - email: david.anderson@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Evaluation of food emergency response laboratories' capability for 210Po analysis using proficiency test material with verifiable traceability.
AU - Wu, Z. Y.
AU - Lin, Z. C.
AU - Mackill, P.
AU - Wei, C.
AU - Noonan, J.
AU - Cherniack, J.
AU - Gillis-Landrum, D.
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
Y1 - 2009///
VL - 282
IS - 3
SP - 971
EP - 977
CY - Dordrecht; Netherlands
PB - Springer
SN - 0236-5731
AD - Wu, Z. Y.: Winchester Engineering and Analytical Center, Food and Drug Administration, 109 Holton Street, Winchester, MA 01890, USA.
N1 - Accession Number: 20103019158. Publication Type: Journal Article; Conference paper. Language: English. Registry Number: 7440-08-6, 7732-18-5. Subject Subsets: World Agriculture, Economics & Rural Sociology; Human Nutrition
N2 - Measurement capability and data comparability are essential for emergency response when analytical data from cooperative laboratories are used for risk assessment and post incident decision making. In this study, the current capability of food emergency response laboratories for the analysis of 210Po in water was evaluated using a proficiency test scheme in compliance with ISO-43 and ILAC G13 guidelines, which comprises a test sample preparation and verification protocol and an insightful statistical data evaluation. The results of performance evaluations on relative bias, value trueness, precision, false positive detection, minimum detection limit, and limit of quantification, are presented.
KW - emergencies
KW - emergency feeding
KW - food aid
KW - laboratories
KW - methodology
KW - polonium
KW - risk assessment
KW - traceability
KW - water
KW - methods
KW - Food Economics (EE116) (New March 2000)
KW - Food Science and Food Products (Human) (QQ000)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103019158&site=ehost-live&scope=site
UR - http://www.springerlink.com/content/6x377655235u1181/?p=82951a4564f4418795f8912fa9b3d336&pi=53
UR - email: zhongyu.wu@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Anthrax lethal toxin enhances IκB kinase activation and differentially regulates pro-inflammatory genes in human endothelium.
AU - Warfel, J. M.
AU - D'Agnillo, F.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009///
VL - 284
IS - 38
SP - 25761
EP - 25771
CY - Bethesda; USA
PB - American Society for Biochemistry and Molecular Biology Inc
SN - 0021-9258
AD - Warfel, J. M.: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Dr., Bldg. 29, Rm. 129, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093291980. Publication Type: Journal Article. Language: English. Number of References: 71 ref. Subject Subsets: Veterinary Science; Veterinary Science; Public Health
N2 - Anthrax lethal toxin (LT) was previously shown to enhance transcriptional activity of NF-κB in tumor necrosis factor-α-activated primary human endothelial cells. Here we show that this LT-mediated increase in NF-κB activation is associated with the enhanced degradation of the inhibitory proteins IκBα and IκBβ but not IκBε. Moreover, this was accompanied by enhanced activation of the IκB kinase complex (IKK), which is responsible for targeting IκB proteins for degradation. Importantly, LT enhancement of IκBα degradation was completely blocked by a selective IKKβ inhibitor, whereas IκBβ degradation was attenuated, suggesting a mechanistic link. Consistent with the above data, LT-cotreated cells show elevated phosphorylation of two IKK substrates, IκBα and p65, both of which were blocked by incubation with the IKKβ inhibitor. Consistent with NF-κB activation, LT increased transcription of the NF-κB regulated gene CD40. Conversely, LT inhibited transcription of another NF-κB-regulated gene, CCL2. This inhibition was linked to the LT-mediated suppression of another CCL2-regulating transcription factor, AP-1 (activator protein-1). These data suggest that LT-mediated enhancement of NF-κB is IKK-dependent, but importantly, the net effect of LT on the transcription of proinflammatory genes is driven by the cumulative effect of LT on the particular set of transcription factors that regulate a given promoter. Together, these findings provide new mechanistic insight on how LT may disrupt the host response to anthrax.
KW - anthrax
KW - bacterial toxins
KW - endothelium
KW - human diseases
KW - inflammation
KW - kinases
KW - molecular biology
KW - transcription factors
KW - Bacillus anthracis
KW - Bacillus (Bacteria)
KW - Bacillaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - Bacteria
KW - prokaryotes
KW - anthrax toxin
KW - bacterium
KW - NF-kappa B
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Toxinology (VV820) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093291980&site=ehost-live&scope=site
UR - http://www.jbc.org/
UR - email: felice.dagnillo@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years.
AU - Kopecko, D. J.
AU - Sieber, H.
AU - Ures, J. A.
AU - Fürer, A.
AU - Schlup, J.
AU - Knof, U.
AU - Collioud, A.
AU - Xu, D. Q.
AU - Colburn, K.
AU - Dietrich, G.
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
Y1 - 2009///
VL - 299
IS - 4
SP - 233
EP - 246
CY - Jena; Germany
PB - Elsevier GmbH
SN - 1438-4221
AD - Kopecko, D. J.: Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, HFM440, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093111923. Publication Type: Journal Article. Language: English. Number of References: 39 ref. Subject Subsets: Public Health
N2 - The attenuated live bacterial vaccine strain Salmonella enterica Serovar Typhi Ty21a is the main constituent of Vivotif, the only licensed oral vaccine against typhoid fever. The strain was developed in the 1970s by chemical mutagenesis. In the course of this mutagenesis, a number of mutations were introduced into the vaccine strain. Characterisation of the vaccine strain during development as well as release of master- and working seed lots (MSL and WSL) and commercial batches is based on phenotypic assays assessing microbiological and biochemical characteristics of Ty21a. In the current study, we have analysed by DNA sequencing the specific mutations originally correlated with the attenuation of strain Ty21a. These data demonstrate the stability of these mutations for MSLs and WSLs of Ty21a produced between 1980 and 2005. Finally, we have confirmed the correlation of these genetic mutations with the expected phenotypic attenuations for the seed lots used in vaccine manufacture over 25 years.
KW - DNA sequencing
KW - genetic analysis
KW - genetic stability
KW - live vaccines
KW - mutations
KW - strains
KW - typhoid
KW - vaccines
KW - Salmonella Typhi
KW - Salmonella enterica subsp. enterica
KW - Salmonella enterica
KW - Salmonella
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - attenuated vaccines
KW - bacterium
KW - nucleotide sequence analysis
KW - nucleotide sequencing
KW - Host Resistance and Immunity (HH600)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093111923&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/14384221
UR - email: guido.h.dietrich@gskbio.com
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza.
AU - Birnkrant, D.
AU - Cox, E.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009///
VL - 361
IS - 23
SP - 2204
EP - 2207
CY - Waltham; USA
PB - Massachusetts Medical Society
SN - 0028-4793
AD - Birnkrant, D.: Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
N1 - Accession Number: 20093340902. Publication Type: Journal Article. Language: English. Number of References: 3 ref. Subject Subsets: Public Health
N2 - On 23 October 2009, Food and Drug Administration Commissioner Margaret Hamburg issued an Emergency Use Authorization (EUA) for peramivir for the treatment of the 2009 H1N1 influenza. This paper briefly discusses the legal basis of this authorization and outlines the criteria for issuing EUAs. It is stressed that health care providers need to recognize that this drug is an unapproved drug authorized for use only because of and during the 2009 H1N1 influenza public health emergency.
KW - antiviral agents
KW - drug therapy
KW - emergencies
KW - health policy
KW - human diseases
KW - influenza A
KW - new drugs
KW - outbreaks
KW - public health
KW - public health legislation
KW - Influenza A virus
KW - man
KW - Influenzavirus A
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - chemotherapy
KW - H1N1 subtype Influenza A virus
KW - peramivir
KW - Health Economics (EE118) (New March 2000)
KW - Policy and Planning (EE120)
KW - Pesticides and Drugs; Control (HH405) (New March 2000)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093340902&site=ehost-live&scope=site
UR - http://www.nejm.org/
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression.
AU - Kulka, M.
AU - Calvo, M. S.
AU - Ngo, D. T.
AU - Wales, S. Q.
AU - Goswami, B. B.
JO - Virology
JF - Virology
Y1 - 2009///
VL - 388
IS - 1
SP - 169
EP - 184
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Kulka, M.: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.
N1 - Accession Number: 20093134550. Publication Type: Journal Article. Language: English. Number of References: many ref. Registry Number: 9008-11-1. Subject Subsets: Public Health
N2 - The latent, constitutively expressed protein RNase L is activated in coxsackievirus and HAV strain 18f infected FRhK-4 cells. Endogenous oligoadenylate synthetase (OAS) from uninfected and virus infected cell extracts synthesizes active forms of the triphosphorylated 2-5A oligomer (the only known activator of RNase L) in vitro and endogenous 2-5A is detected in infected cell extracts. However, only the largest OAS isoform, OAS3, is readily detected throughout the time course of infection. While IFNβ treatment results in an increase in the level of all three OAS isoforms in FRhK-4 cells, IFNβ pretreatment does not affect the temporal onset or enhancement of RNase L activity nor inhibit virus replication. Our results indicate that CVB1 and HAV/18f activate the 2-5OAS/RNase L pathway in FRhK-4 cells during permissive infection through endogenous levels of OAS, but contrary to that reported for some picornaviruses, CVB1 and HAV/18f replication is insensitive to this activated antiviral pathway.
KW - biochemical pathways
KW - cell lines
KW - in vitro
KW - interferon
KW - ribonucleases
KW - strains
KW - viral diseases
KW - viral replication
KW - Maryland
KW - USA
KW - Hepatitis A virus
KW - Hepatovirus
KW - Picornaviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - South Atlantic States of USA
KW - Southern States of USA
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - metabolic pathways
KW - RNASE
KW - United States of America
KW - viral infections
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093134550&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXR-4W3SNDR-1&_user=6686535&_coverDate=05%2F25%2F2009&_rdoc=20&_fmt=high&_orig=browse&_srch=doc-info(%23toc%237165%232009%23996119998%231024408%23FLA%23display%23Volume)&_cdi=7165&_sort=d&_docanchor=&_ct=25&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=4fcd3bddfd00d2e68e0432bd84f348e1
UR - email: michael.kulka@fda.hhs.gov\mona.calvo@fda.hhs.gov\diana.ngo@fda.hhs.gov\samantha.wales@fda.hhs.gov\biswendu.goswami@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Changes of the receptor-binding properties of influenza B virus B/Victoria/504/2000 during adaptation in chicken eggs.
AU - Lugovtsev, V. Y.
AU - Smith, D. F.
AU - Weir, J. P.
JO - Virology
JF - Virology
Y1 - 2009///
VL - 394
IS - 2
SP - 218
EP - 226
CY - San Diego; USA
PB - Elsevier Inc.
SN - 0042-6822
AD - Lugovtsev, V. Y.: Laboratory of Respiratory Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bldg. 29A, Room 2B17, Bethesda, MD 20892, USA.
N1 - Accession Number: 20093335829. Publication Type: Journal Article. Language: English. Subject Subsets: Human Nutrition
N2 - Selection of high-growth virus variants of strain B/Victoria/504/2000 by serial passage in eggs resulted in three amino acid substitutions, G141E, R162M, and D196Y, in the vicinity of the receptor-binding pocket of viral hemagglutinin. Virus variants containing the identified amino acid substitutions, individually or in various combinations, were constructed using reverse genetics and analyzed for their receptor-binding properties using glycan microarray platform. Three different patterns of virus binding were revealed. A low-growth virus variant, corresponding to the original egg-derived virus B/Victoria/504/2000 prior to acquisition of amino acid changes G141E, R162M, and D196Y, had a clear preference for the oligosaccharide chains terminated with α2-6-linked sialic acid with very weak binding of the glycans terminated with α2-3-linked sialic acid. Amino acid substitutions R162M and D196Y had similar effects, resulting in viruses that bound with high efficiency almost all terminally sialylated glycans represented on the array regardless of the type of glycosidic linkage. In contrast, substitution of G141E alone, or in combinations with the other two amino acid substitutions, significantly restricted virus glycan-binding capabilities. All virus variants possessing this substitution lost the ability to bind glycans with α2-6 glycosidic linkage as well as most of the glycans with α2-3 glycosidic linkage. Linear penta- and heptasaccharide chains represented at the non-reducing end by α2-3 sialylated Type-II motif (LacNAc) were the only structures bound with high affinity by the virus variants with G141E substitution. In all cases when the effects on virus binding of individual amino acid substitutions differed, the effect of R162M was subordinate to the effect of either G141E or D196Y.
KW - adaptation
KW - amino acids
KW - binding
KW - eggs
KW - influenza B
KW - influenza viruses
KW - sialic acids
KW - Orthomyxoviridae
KW - negative-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Influenzavirus
KW - Eggs and Egg Products (QQ040)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093335829&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXR-4X8BP5T-1&_user=10&_coverDate=11%2F25%2F2009&_rdoc=7&_fmt=high&_orig=browse&_srch=doc-info(%23toc%237165%232009%23996059997%231560136%23FLA%23display%23Volume)&_cdi=7165&_sort=d&_docanchor=&_ct=18&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a68abbb3819610d834c1e86f3aed23cf
UR - email: vladimir.lugovtsev@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Stir bar sorptive extraction-gas chromatography-mass spectrometry analysis of tetramethylene disulfotetramine in food: method development and comparison to solid-phase microextraction.
AU - Jager, L. S. de
AU - Perfetti, G. A.
AU - Diachenko, G. W.
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2009///
VL - 635
IS - 2
SP - 162
EP - 166
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0003-2670
AD - Jager, L. S. de: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
N1 - Accession Number: 20093057598. Publication Type: Journal Article. Language: English. Number of References: 12 ref. Subject Subsets: Human Nutrition
N2 - A stir bar sorptive extraction-gas chromatography-mass spectrometry (SBSE-GC-MS) method for the determination of tetramethylene disulfotetramine is presented. The limits of detection (LOD) of the optimized method was 0.2 ng g-1 for extractions from water and 0.3-2.1 ng g-1 for extractions from foods. Recovery was highly matrix dependent (36-130%) and quantification required standard addition calibrations. Standard addition calibration lines had high linearity (R2>0.97) and replicate extractions had good reproducibility (R.S.D.=4.4-9.8%). A comparison of the SBSE method and a previously developed headspace (HS)-solid-phase microextraction (SPME) method was performed. Generally, SBSE provided higher sensitivity with decreased analysis time.
KW - detection
KW - food
KW - food composition
KW - GC-MS
KW - quantitative analysis
KW - quantitative techniques
KW - gas chromatography-mass spectrometry
KW - tetramethylene disulfotetramine
KW - Food Composition and Quality (QQ500)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093057598&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF4-4VB5K3C-3&_user=6686535&_coverDate=03%2F09%2F2009&_rdoc=6&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235216%232009%23993649997%23909057%23FLA%23display%23Volume)&_cdi=5216&_sort=d&_docanchor=&_ct=16&_acct=C000066028&_version=1&_urlVersion=0&_userid=6686535&md5=cddc4f02b79211045e6599a12fdb226f
UR - email: lowri.dejager@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.
AU - Pogribny, I. P.
AU - Shpyleva, S. I.
AU - Muskhelishvili, L.
AU - Bagnyukova, T. V.
AU - James, S. J.
AU - Beland, F. A.
JO - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis
Y1 - 2009///
VL - 669
IS - 1/2
SP - 56
EP - 62
CY - Amsterdam; Netherlands
PB - Elsevier
SN - 0027-5107
AD - Pogribny, I. P.: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
N1 - Accession Number: 20093315072. Publication Type: Journal Article. Language: English. Number of References: 49 ref. Registry Number: 9007-49-2. Subject Subsets: Human Nutrition
N2 - Currently, cancer is recognized as a disease provoked by both genetic and epigenetic events. However, the significance of early genetic and epigenetic alterations with respect to carcinogenic process in general and to liver carcinogenesis in particular remains unexplored. A lack of knowledge regarding how specific alterations during early preneoplasia may be mechanistically related to tumor formation creates a major gap in understanding the role of these genetic and epigenetic abnormalities in carcinogenesis. In the present study we investigated the contribution of DNA damage and epigenetic alterations to liver carcinogenesis induced by a methyl-deficient diet. Feeding Fisher 344 rats a methyl-deficient diet for 9 weeks resulted in DNA damage and aberrant DNA methylation. This was evidenced by an early up-regulation of the base excision DNA repair genes, accumulation of 8-oxodeoxyguanosine and 3′OH-end strand breaks in DNA, pronounced global loss of DNA methylation, and hypermethylation of CpG islands in the livers of methyl-deficient rats. These abnormalities were completely restored in the livers of rats exposed to methyl-deficiency for 9 weeks after removal of the methyl-deficient diet and re-feeding a methyl-sufficient diet. However, when rats were fed a methyl-deficient diet for 18 week and then given a methyl-sufficient diet, only DNA lesions were repaired. The methyl-sufficient diet failed to restore completely the altered DNA methylation status and prevent the progression of liver carcinogenesis. These results suggest that stable alterations in DNA methylation are a factor that promotes the progression of liver carcinogenesis. Additionally, the results indicate that epigenetic changes may be more reliable markers than DNA lesions of the carcinogenic process and carcinogen exposure.
KW - animal diseases
KW - carcinogenesis
KW - carcinoma
KW - diet
KW - disease course
KW - DNA
KW - human diseases
KW - laboratory animals
KW - liver
KW - liver cancer
KW - liver diseases
KW - methylation
KW - neoplasms
KW - rats
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - cancers
KW - deoxyribonucleic acid
KW - disease progression
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Nutrition Related Disorders and Therapeutic Nutrition (VV130)
KW - Animal Models of Human Nutrition (VV140)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093315072&site=ehost-live&scope=site
UR - http://www.sciencedirect.com/science/journal/00275107
UR - email: igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Genotypic and phenotypic assessment of hyaluronidase among type strains of a select group of staphylococcal species.
AU - Hart, M. E.
AU - Hart, M. J.
AU - Roop, A. J.
JO - International Journal of Microbiology
JF - International Journal of Microbiology
Y1 - 2009///
VL - 2009
SP - Article ID 614371
EP - Article ID 614371
CY - New York; USA
PB - Hindawi Publishing Corporation
SN - 1687-918X
AD - Hart, M. E.: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.
N1 - Accession Number: 20103212376. Publication Type: Journal Article. Language: English. Number of References: 32 ref. Registry Number: 9007-49-2, 9004-61-9, 37288-34-9. Subject Subsets: Public Health
N2 - Hyaluronidases degrade hyaluronic acid, a major polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. The purpose of the present study was to determine the prevalence of hyaluronidase among clinical strains of Staphylococcus aureus and among other Staphylococcus species. Spent media and chromosomal DNA were assessed for hyaluronidase activity and the absence or presence of a hyaluronidase gene (hysA) by Southern analysis, respectively. All S. aureus strains examined exhibited at least one hybridizing band (half of the strains exhibited two or more hybridizing bands) when probed for hysA and all but three of these strains produced hyaluronidase. In contrast, none of the type strains of 19 other species exhibited either hyaluronidase activity or hybridizing bands when probed for hysA. These data support the hypothesis that among members of the Staphylococcus genus only strains of S. aureus possess the enzyme hyaluronidase. This would suggest that hyaluronidase represents yet another potential virulence factor employed by S. aureus to cause disease and may represent a diagnostically important characteristic for distinguishing S. aureus from other members of this genus.
KW - disease prevalence
KW - DNA
KW - enzyme activity
KW - enzymes
KW - epidemiology
KW - genes
KW - genotypes
KW - Gram negative bacteria
KW - Gram positive bacteria
KW - human diseases
KW - hyaluronic acid
KW - hyaluronidase
KW - phenotypes
KW - virulence factors
KW - Bacteria
KW - man
KW - Staphylococcus aureus
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Staphylococcus
KW - Staphylococcaceae
KW - Bacillales
KW - Bacilli
KW - Firmicutes
KW - bacterium
KW - deoxyribonucleic acid
KW - Gram-negative bacteria
KW - Gram-positive bacteria
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103212376&site=ehost-live&scope=site
UR - http://www.hindawi.com/journals/ijmb/2009/614371.html
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Monensin.
AU - Friedlander, L. G.
AU - Sanders, P.
T2 - FAO JECFA Monographs
JO - FAO JECFA Monographs
JF - FAO JECFA Monographs
Y1 - 2009///
IS - 6
CY - Rome; Italy
PB - Food and Agriculture Organization of the United Nations (FAO)
SN - 1817-7077
AD - Friedlander, L. G.: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20093131765. Publication Type: Bulletin article; Conference paper. Language: English. Number of References: many ref. Registry Number: 17090-79-8. Subject Subsets: Veterinary Science; Pig Science; Poultry
N2 - This monograph focuses on residue evaluations of monensin. It provides information on identity of substance, residues in food and their evaluation, metabolism studies (rats, cattle, chickens, dogs, horses, pigs and sheep), tissue residue depletion studies, methods of residue analysis, a final appraisal of the study results, and recommendations on maximum residue limits.
KW - analytical methods
KW - animal models
KW - chemical structure
KW - chemistry
KW - drug metabolism
KW - drug residues
KW - food contamination
KW - food safety
KW - guidelines
KW - laboratory animals
KW - methodology
KW - monensin
KW - monographs
KW - pharmacokinetics
KW - poultry
KW - quality controls
KW - tissue distribution
KW - veterinary products
KW - cattle
KW - dogs
KW - fowls
KW - horses
KW - pigs
KW - rats
KW - sheep
KW - Bos
KW - Bovidae
KW - ruminants
KW - Artiodactyla
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Canis
KW - Canidae
KW - Fissipeda
KW - carnivores
KW - Gallus gallus
KW - Gallus
KW - Phasianidae
KW - Galliformes
KW - birds
KW - Equus
KW - Equidae
KW - Perissodactyla
KW - Sus scrofa
KW - Sus
KW - Suidae
KW - Suiformes
KW - Muridae
KW - rodents
KW - Ovis
KW - analytical techniques
KW - animal health products
KW - chickens
KW - domesticated birds
KW - food contaminants
KW - hogs
KW - methods
KW - quality assurance
KW - recommendations
KW - rumensin
KW - swine
KW - Pesticide and Drug Residues and Ecotoxicology (HH430) (New March 2000)
KW - Veterinary Pharmacology and Anaesthesiology (LL882) (New March 2000)
KW - Meat Produce (QQ030)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Techniques and Methodology (ZZ900)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093131765&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Reporting of systematic reviews of micronutrients and health: a critical appraisal.
T2 - Technical Reviews - Agency for Healthcare Research and Quality
T3 - Nutrition Research Series, Vol. 3
JO - Technical Reviews - Agency for Healthcare Research and Quality
JF - Technical Reviews - Agency for Healthcare Research and Quality
Y1 - 2009///
IS - 17.3
CY - Rockville; USA
PB - Department of Health & Human Services, Public Health Service, National Institutes of Health, National Institute of Mental Health
AD - Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850, USA.
N1 - Accession Number: 20113336503. Publication Type: Bulletin. Note: Nutrition Research Series, Vol. 3 Language: English. Number of References: 183 ref. Subject Subsets: Human Nutrition
N2 - Background: The quality of nutrition-related systematic reviews (SR) is an unstudied but important factor affecting their usefulness. Objective: To evaluate reporting quality of published SRs and identify areas for improvement. Design: Descriptive and exploratory analyses of reporting quality (7 nutrition items and 28 SR reporting items) of all English-language SRs published through July 2007 linking micronutrients and health outcomes in humans. Factors that may to be associated with the reporting quality were also evaluated. Results: We found 141 eligible SRs of 21 micronutrients. Ninety SRs that included only interventional studies met a higher proportion of our reporting criteria (median: 62 percent, interquartile range (IQR): 51 percent, 72 percent) than 31 SRs with only observational studies (median: 53 percent, IQR: 47 percent, 60 percent) or 20 SRs with both study designs (median: 47 percent, IQR: 39 percent, 52 percent) (P<0.001). SRs published after consensus reporting standards (since 2003) met a higher proportion of the reporting criteria than earlier SRs (median: 59 percent versus 50 percent, P=0.01); however, the reporting of nutrition variables remained unchanged (median: 38 percent versus 33 percent, P=0.7). The least-reported nutrition criteria were baseline nutrient exposures (28 percent) and impacts of the measurement errors from nutrition exposures (24 percent). Only 58 SRs (41 percent) used quality scales or checklists to assess the methodological quality of the primary studies included. Conclusions: The reporting quality of SRs has improved 3 years after publication of SR reporting standards (since 2003), but the reporting of nutrition variables has not. Improved adherence to consensus methods and reporting standards should improve the utility of nutrition SRs.
KW - health
KW - literature reviews
KW - nutrition
KW - quality
KW - reviews
KW - standards
KW - systematic reviews
KW - trace elements
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - microelements
KW - Human Nutrition (General) (VV100)
KW - Physiology of Human Nutrition (VV120)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20113336503&site=ehost-live&scope=site
UR - http://www.ahrq.gov/downloads/pub/evidence/pdf/nutrition/nutrtp3.pdf
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens.
AU - Crill, W. D.
AU - Hughes, H. R.
AU - Delorey, M. J.
AU - Chang, G. J. J.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009///
IS - April
SP - e4991
EP - e4991
CY - San Francisco; USA
PB - Public Library of Sciences (PLoS)
SN - 1932-6203
AD - Crill, W. D.: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Service, Fort Collins, Colorado, USA.
N1 - Accession Number: 20103247715. Publication Type: Journal Article. Language: English. Number of References: 69 ref. Subject Subsets: Public Health; Medical & Veterinary Entomology; Tropical Diseases
N2 - Dengue virus (DENV) is a serious mosquito-borne pathogen causing significant global disease burden, either as classic dengue fever (DF) or in its most severe manifestation dengue hemorrhagic fever (DHF). Nearly half of the world's population is at risk of dengue disease and there are estimated to be millions of infections annually; a situation which will continue to worsen with increasing expansion of the mosquito vectors and epidemic DF/DHF. Currently there are no available licensed vaccines or antivirals for dengue, although significant effort has been directed toward the development of safe and efficacious dengue vaccines for over 30 years. Promising vaccine candidates are in development and testing phases, but a better understanding of immune responses to DENV infection and vaccination is needed. Humoral immune responses to DENV infection are complex and may exacerbate pathogenicity, yet are essential for immune protection. In this report, we develop DENV-2 envelope (E) protein epitope-specific antigens and measure immunoglobulin responses to three distinct epitopes in DENV-2 infected human serum samples. Immunoglobulin responses to DENV-2 infection exhibited significant levels of individual variation. Antibody populations targeting broadly cross-reactive epitopes centered on the fusion peptide in structural domain II were large, highly variable, and greater in primary than in secondary DENV-2 infected sera. E protein domain III cross-reactive immunoglobulin populations were similarly variable and much larger in IgM than in IgG. DENV-2 specific domain III IgG formed a very small proportion of the antibody response yet was significantly correlated with DENV-2 neutralization, suggesting that the highly protective IgG recognizing this epitope in murine studies plays a role in humans as well. This report begins to tease apart complex humoral immune responses to DENV infection and is thus important for improving our understanding of dengue disease and immunological correlates of protection, relevant to DENV vaccine development and testing.
KW - dengue
KW - epitopes
KW - human diseases
KW - viral antigens
KW - viral proteins
KW - Dengue virus
KW - man
KW - Flavivirus
KW - Flaviviridae
KW - positive-sense ssRNA viruses
KW - ssRNA viruses
KW - RNA viruses
KW - viruses
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - antigenic determinants
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Human Immunology and Allergology (VV055) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103247715&site=ehost-live&scope=site
UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0004991
UR - email: wcrill@cdc.gov
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
T1 - Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.
AU - Oakley, M. S.
AU - Majam, V.
AU - Mahajan, B.
AU - Gerald, N.
AU - Anantharaman, V.
AU - Ward, J. M.
AU - Faucette, L. J.
AU - McCutchan, T. F.
AU - Zheng, H.
AU - Terabe, M.
AU - Berzofsky, J. A.
AU - Aravind, L.
AU - Kumar, S.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009///
IS - August
SP - e6793
EP - e6793
CY - San Francisco; USA
PB - Public Library of Sciences (PLoS)
SN - 1932-6203
AD - Oakley, M. S.: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, Maryland, USA.
N1 - Accession Number: 20103266493. Publication Type: Journal Article. Language: English. Number of References: 62 ref. Subject Subsets: Protozoology
N2 - An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has been useful in predicting the functional classes of genes involved and pathways altered during the course of disease. To further understand the contribution of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules - CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM. We find that CD14 plays a predominant role in the induction of ECM and regulation of parasite density; deletion of the CD14 gene not only prevented the onset of disease in a majority of susceptible mice (only 21% of CD14-deficient compared to 80% of wildtype mice developed ECM, p<0.0004) but also had an ameliorating effect on parasitemia (a 2 fold reduction during the cerebral phase). Furthermore, deletion of the galectin-3 gene in susceptible C57BL/6 mice resulted in partial protection from ECM (47% of galectin-3-deficient versus 93% of wildtype mice developed ECM, p<0.0073). Subsequent adherence assays suggest that galectin-3 induced pathogenesis of ECM is not mediated by the recognition and binding of galectin-3 to P. berghei ANKA parasites. A previous study of ECM has demonstrated that brain infiltrating T cells are strongly activated and are CD44+CD62L- differentiated memory T cells [1]. We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4+ and CD8+ T cells accumulated in the brain vasculature is approximately equal.
KW - animal models
KW - antigens
KW - cerebral malaria
KW - disease models
KW - experimental infection
KW - genes
KW - laboratory animals
KW - pathogenesis
KW - pathogenicity
KW - T lymphocytes
KW - mice
KW - Plasmodium berghei
KW - Muridae
KW - rodents
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodium
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - antigenicity
KW - CD14 antigens
KW - experimental transmission
KW - galectin 3
KW - immunogens
KW - T cells
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
KW - Animal Models of Human Diseases (VV400) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20103266493&site=ehost-live&scope=site
UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006793
UR - email: sanjai.kumar@fda.hhs.gov
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Web-based public health information dissemination and evaluation.
AU - Siegel, E. R.
AU - Wood, F. B.
AU - Scott, J. C.
AU - Royall, J.
A2 - Detels, R.
A2 - Beaglehole, R.
A2 - Lansing, M. A.
A2 - Gulliford, M.
T2 - Oxford textbook of public health, Volume 2: the methods of public health
Y1 - 2009///
IS - Ed.5
CY - Oxford; UK
PB - Oxford University Press
SN - 9780199579440
AD - Siegel, E. R.: Health Information Programs Development, US National Library of Medicine, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
N1 - Accession Number: 20093342137. Publication Type: Book chapter. Language: English. Number of References: 46 ref. Subject Subsets: Protozoology; Public Health; Tropical Diseases
N2 - This chapter focuses on the current status of what is called Web-based health information dissemination. The chapter highlights the proliferation of Web sites for public health organizations and institutions of all types that has occurred in recent years. The chapter next addresses the dramatic potential of Web-based applications for Emergency Preparedness and Disaster Management for all countries, whether high-, middle-, or low-income. This includes the use of Web-based networks of satellites, sensors, data mining, and analytics. The chapter presents two case studies on emergency preparedness: Wireless Information System for Emergency Responders (WISER); and Central American Network for Disaster Health Information (CANDHI). The chapter then discusses a major Web-based health application in low-income countries - the Health InterNetwork Access to Research Initiative (HINARI); and provides an update on the Multinational Initiative on Malaria (MIM) and its use of Web-based dissemination of scientific research. Finally, the chapter presents a multidimensional approach to Web evaluation that includes methods to determine: (1) How well the Web sites are meeting customer or citizen needs; and (2) what design, content, functionality, and performance improvements may be needed to better meet user needs. The Web will continue to grow as an important part of the public health information infrastructure in many countries. The key role of the Web can exacerbate the digital divide, to the extent access and use are more heavily concentrated in urbanized and higher income areas. On the other hand, the Web can help improve access to public health information much more broadly than was possible in the pre-Web era. Given the growing role of the Web in public and consumer health, a robust approach to Web evaluation is important.
KW - disasters
KW - human diseases
KW - information systems
KW - internet
KW - malaria
KW - public health
KW - remote sensing
KW - man
KW - Plasmodium
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - Plasmodiidae
KW - Haemospororida
KW - Apicomplexa
KW - Protozoa
KW - invertebrates
KW - emergency preparedness
KW - web sites
KW - Information and Documentation (CC300)
KW - Protozoan, Helminth and Arthropod Parasites of Humans (VV220) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093342137&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - People with disabilities.
AU - Lollar, D.
A2 - Detels, R.
A2 - Beaglehole, R.
A2 - Lansang, M. A.
A2 - Gulliford, M.
T2 - Oxford textbook of public health, Volume 3: the practice of public health
Y1 - 2009///
IS - Ed.5
CY - Oxford; UK
PB - Oxford University Press
SN - 9780199579457
AD - Lollar, D.: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, United States Department of Health and Human Services, Atlanta, Georgia, USA.
N1 - Accession Number: 20093342104. Publication Type: Book chapter. Language: English. Number of References: many ref. Subject Subsets: Public Health; Tropical Diseases
N2 - Disability is traditionally associated with morbidity and mortality as the negative public health outcomes. Primary prevention activities addressing birth defects, developmental disabilities, injuries, and chronic illnesses associated with disabling conditions are seminal to public health. There are, however, always going to be people in the population who fall through the primary prevention net and live with disabling conditions. Public health is beginning to acknowledge the potential role it plays in promoting the health and well-being of this population. This chapter addresses the emerging field of public health and disability. The essential public health functions of assessment, policy development, and assurance are outlined for this population across countries and age groups. The World Health Organization's International Classification of Functioning, Disability and Health provides the framework for the conceptual and scientific issues. Clarifying definitions of 'disability' for purposes of public health surveillance and epidemiology, as well as research, are major emphases, including child disability measurement and caregiving or carers. Policy development emerges from the national and international conventions and activities, including the recently adopted UN Convention on the Rights of People with Disabilities, and supports the notion that the public health and disability communities have mutual responsibility for improving the health and well-being of this population. Assurance begins by asserting the relationship between poverty and disability, and includes discussion on interventions such as clinical preventive services, along with community-based rehabilitation activities. Finally, the chapter outlines directions for public health and disability to develop more fully. Recommendations are made for improving communication, cooperation, and coordination of activities between the public health and disability communities. Curricula are coming available for the education and training of public health professionals in disability. Use of these curricula is strongly encouraged so that people with disabilities are included in public health science, programmes, and policy activities.
KW - careproviders
KW - case definitions
KW - children with disabilities
KW - disabilities
KW - disease prevention
KW - epidemiology
KW - health education
KW - health policy
KW - human diseases
KW - medical research
KW - people with disabilities
KW - poverty
KW - public health
KW - public health services
KW - reviews
KW - surveillance
KW - WHO
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - clinical case definitions
KW - disabled people
KW - disabled persons
KW - handicapped children
KW - handicapped people
KW - handicapped persons
KW - World Health Organization
KW - Health Economics (EE118) (New March 2000)
KW - Policy and Planning (EE120)
KW - Income and Poverty (EE950)
KW - Health Services (UU350)
KW - Non-communicable Human Diseases and Injuries (VV600)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093342104&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - The role of the federal government in supporting state newborn screening programs.
AU - Lloyd-Puryear, M. A.
AU - Therrell, B. L.
AU - Mann, M. Y.
AU - Eckman, J. R.
AU - Telfair, J.
A2 - Baily, M. A.
A2 - Murray, T. H.
T2 - Ethics and newborn genetic screening: new technologies, new challenges
Y1 - 2009///
CY - Baltimore; USA
PB - Johns Hopkins University Press
SN - 9780801891519\0801891515
AD - Lloyd-Puryear, M. A.: Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland, USA.
N1 - Accession Number: 20093357543. Publication Type: Book chapter. Language: English. Number of References: 39 ref. Subject Subsets: Public Health; World Agriculture, Economics & Rural Sociology
N2 - This chapter describes the ways in which the federal government has engaged in the process of translating research into improvements in states' population-based newborn screening programs. In order to provide a clear description, four examples are provided specifically those concerning the research for phenylketonuria, newborn screening for sickle cell disease, use of a newborn screening task force and other federal advisory groups in policy development, and program evaluation as a part of quality assurance and continuous improvement. Future roles for the federal government in expanding and improving newborn screening activities are also presented.
KW - development programmes
KW - federal government
KW - genetic analysis
KW - genetic disorders
KW - human diseases
KW - hyperphenylalaninaemia
KW - neonates
KW - phenylketonuria
KW - screening
KW - sickle cell anaemia
KW - man
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - development programs
KW - genetic defects
KW - hereditary defects
KW - hyperphenylalaninemia
KW - newborn infants
KW - newborn screening
KW - Phenylalanine hydroxylase deficiency
KW - screening tests
KW - sickle cell anemia
KW - Agencies and Organizations (DD100)
KW - Policy and Planning (EE120)
KW - Human Genetics and Molecular Medicine (VV080) (New June 2002)
KW - Non-communicable Human Diseases and Injuries (VV600)
KW - Diagnosis of Human Disease (VV720) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093357543&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Antimicrobial resistance in food-borne pathogens.
AU - White, D. G.
AU - McDermott, P. F.
A2 - Jaykus, L. A.
A2 - Wang, H. H.
A2 - Schlesinger, L. S.
T2 - Food-borne microbes: shaping the host ecosystem
Y1 - 2009///
CY - Washington; USA
PB - ASM Press
SN - 9781555814052
AD - White, D. G.: Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA.
N1 - Accession Number: 20093138966. Publication Type: Book chapter. Language: English. Number of References: 221 ref. Subject Subsets: Human Nutrition; Public Health
N2 - This chapter focuses on the occurrence of antimicrobial-resistant phenotypes among selected food-borne bacteria, with an emphasis on isolates recovered from foods of animal origin and the potential public health consequences. Current risk assessment and risk management strategies to mitigate the spread of antimicrobial-resistant foodborne bacteria are also discussed.
KW - antibacterial agents
KW - bacterial diseases
KW - drug resistance
KW - food contamination
KW - foodborne diseases
KW - human diseases
KW - microbial contamination
KW - phenotypes
KW - risk assessment
KW - Bacteria
KW - man
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - food contaminants
KW - Pesticide and Drug Resistance (HH410)
KW - Food Contamination, Residues and Toxicology (QQ200)
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093138966&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Regulation of genetically engineered animals containing heritable recombinant DNA constructs.
AU - Rudenko, L.
T2 - Regulation of genetically engineered animals containing heritable recombinant DNA constructs
T3 - Guidance for Industry No. 187
Y1 - 2009///
CY - Rockville; USA
PB - Center for Veterinary Medicine
AD - Rudenko, L.: Animal Biotechnology Staff, Center for Veterinary Medicine (HFV-100), Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA.
N1 - Accession Number: 20093114618. Publication Type: Book. Note: Guidance for Industry No. 187 Language: English. Registry Number: 9007-49-2. Subject Subsets: Agricultural Biotechnology; Animal Breeding
N2 - The US Food and Drug Administration's current thinking on the topic of transgenic animals with heritable recombinant DNA constructs is presented. Issues such as investigational use of genetically engineered (GE) animals, food use of GE animals, new animal drug application requirements, molecular characterization of GE animal lineage and phenotypic characterization of GE animals, are discussed as well.
KW - DNA
KW - drug development
KW - food safety
KW - genetically engineered organisms
KW - molecular genetics
KW - transgenic animals
KW - USA
KW - APEC countries
KW - Developed Countries
KW - North America
KW - America
KW - OECD Countries
KW - biochemical genetics
KW - deoxyribonucleic acid
KW - genetically engineered animals
KW - genetically modified animals
KW - genetically modified organisms
KW - GEOs
KW - GMOs
KW - United States of America
KW - Genetic Engineering, Gene Transfer and Transgenics (WW100) (New June 2002)
KW - Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000)
KW - General Molecular Biology (ZZ360) (Discontinued March 2000)
KW - Animal Genetics and Breeding (LL240) (New March 2000)
KW - Food Contamination, Residues and Toxicology (QQ200)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093114618&site=ehost-live&scope=site
UR - http://www.fda.gov/cvm/GEAnimals.htm
DP - EBSCOhost
DB - lhh
ER -
TY - GEN
T1 - Escherichia coli: enteric and extraintestinal infections.
AU - Lorenz, B. D.
AU - Donnenberg, M. S.
A2 - Fratamico, P. M.
A2 - Smith, J. L.
A2 - Brogden, K. A.
T2 - Sequelae and long-term consequences of infectious diseases
Y1 - 2009///
CY - Washington; USA
PB - ASM Press
SN - 1555814301\9781555814304
AD - Lorenz, B. D.: Center for Drug Evaluation Research, Division of Anti-Infective and Ophthalmology Products, U.S. Food and Drug Administration, Silver Spring, MD 20933, USA.
N1 - Accession Number: 20093226339. Publication Type: Book chapter. Language: English. Number of References: 203 ref. Subject Subsets: Public Health
N2 - This chapter discusses the 6 different Escherichia coli pathotypes together with their distinct epidemiological patterns, virulence factors, and clinical presentation. The long-term consequences associated with E. coli, including meningitis, recurrent urinary tract infections, persistent diarrhoea, irritable bowel syndrome, inflammatory bowel disease and reactive arthritis, are described. The prevention, treatment and control of E. coli infections are also presented.
KW - arthritis
KW - bacterial diseases
KW - bacterial meningitis
KW - clinical aspects
KW - complications
KW - diarrhoea
KW - disease control
KW - disease course
KW - disease prevention
KW - epidemiology
KW - human diseases
KW - irritable colon
KW - pathotypes
KW - therapy
KW - urinary tract infections
KW - virulence
KW - Escherichia coli
KW - man
KW - Escherichia
KW - Enterobacteriaceae
KW - Enterobacteriales
KW - Gammaproteobacteria
KW - Proteobacteria
KW - Bacteria
KW - prokaryotes
KW - Homo
KW - Hominidae
KW - Primates
KW - mammals
KW - vertebrates
KW - Chordata
KW - animals
KW - eukaryotes
KW - bacterial infections
KW - bacterioses
KW - bacterium
KW - clinical picture
KW - diarrhea
KW - disease progression
KW - E. coli
KW - IBS
KW - inflammatory bowel disease
KW - irritable bowel syndrome
KW - scouring
KW - spastic colon
KW - therapeutics
KW - Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
KW - Biochemistry and Physiology of Microorganisms (ZZ394) (New March 2000)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lhh&AN=20093226339&site=ehost-live&scope=site
DP - EBSCOhost
DB - lhh
ER -
TY - JOUR
ID - 107375243
T1 - CDRH summary report. FDA summarizes radiation therapy device problems.
AU - Kaczmarek RV
Y1 - 1996///Spring1996
N1 - Accession Number: 107375243. Language: English. Entry Date: 19960701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9206619.
KW - Radiotherapy -- Equipment and Supplies
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 69
EP - 70
JO - Radiation Therapist
JF - Radiation Therapist
JA - RADIAT THERAPIST
VL - 5
IS - 1
CY - Alburquerque, New Mexico
PB - American Society of Radiologic Technologists
SN - 1084-1911
AD - FDA's Center for Devices and Radiological Health
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107375243&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107022481
T1 - Who are we to say?
AU - Einterz EM
Y1 - 1996/03//Mar/Apr96
N1 - Accession Number: 107022481. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe. NLM UID: 0414011.
KW - Health Beliefs
KW - Culture
KW - Socioeconomic Factors
SP - 20
EP - 21
JO - World Health
JF - World Health
JA - WORLD HEALTH
VL - 49
IS - 2
PB - World Health Organization
SN - 0043-8502
AD - District Medical Officer, District Hospital and Public Health Service, District of Kolofata, Hôpital de District de Kolofata, B.P. 111, Mora, Extrême-Nord, Cameroon
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107022481&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1996-04511-002
AN - 1996-04511-002
AU - Hardaway, Ernest
AU - Wence, Fran
AU - Bingaman, David
AU - Selvik, Rick
T1 - The employee assistance program: Help for court managers and employees in the changing workplace.
JF - Federal Probation
JO - Federal Probation
JA - Fed Probat
Y1 - 1996/03//
VL - 60
IS - 1
SP - 60
EP - 66
CY - US
PB - Administrative Office of the United States Courts
SN - 0014-9128
SN - 1555-0303
N1 - Accession Number: 1996-04511-002. Partial author list: First Author & Affiliation: Hardaway, Ernest; Div of Federal Occupational Health, Region V, Public Health service, Chicago, IL, US. Release Date: 19960101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Job Performance; Management Training. Minor Descriptor: Legal Personnel; Management Personnel. Classification: Personnel Management & Selection & Training (3620); Forensic Psychology & Legal Issues (4200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 7. Issue Publication Date: Mar, 1996.
AB - Discusses employee problems and job performance, reviews the courts' use of the Employee Assistance Program (EAP) during fiscal year 1995, explains the steps for managers to refer employees to the EAP, and describes training and education available through the EAP. The purpose of EAP training is to develop employee and supervisor awareness and understanding of the EAP and to demonstrate how the EAP benefits both the employee and the organization by furthering better job performance, better employee relations, and a better work environment. The EAP also plays a key role in the prevention of workplace violence and in the development of a practical, comprehensive response to volatile and traumatic incidents. It is suggested that court managers make more use of the EAP by calling for management consultation on workplace issues and referring employees with job performance problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - training & role in referring employees to EAPs
KW - employee problems & job performance
KW - court managers
KW - 1996
KW - Employee Assistance Programs
KW - Job Performance
KW - Management Training
KW - Legal Personnel
KW - Management Personnel
KW - 1996
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - YETLEY, ELIZABETH A.
AU - RADER, JEANNE I.
T1 - The Challenge of Regulating Health Claims and Food Fortification.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996/03/02/Mar96 Supplement
M3 - Article
SP - 765S
EP - 772S
SN - 00223166
AB - The Food and Drug Administration has several options that will assist the Public Health Ser vice in implementing its September 1992 recommen dation that all women of childbearing age consume 0.4 mg of folie acid daily to reduce their risk of having a pregnancy affected with a neural tube defect. The FDA can authorize the use of a health claim on labels and in the labeling of foods that characterizes the relationship between a nutrient and a health-related condition. For tification of cereal-grain products with folie acid is a second option that has the potential for reaching most women of childbearing age without requiring them to change their food selection patterns. Consideration of these options has been intertwined with rapid develop ments in the scientific database that is the foundation of the health claim, by conflicting opinions regarding the effectiveness for women in the target population of FDA's proposed level of cereal-grain fortification, by lack of systematic safety data regarding the impact of fortification on persons in the general population and by changes in the regulatory environment in which the agency acts. J. Nutr. 126: 765S-772S, 1996. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - folic acid
KW - fortification
KW - health claims
KW - neural tube defects
KW - public policy
N1 - Accession Number: 89382815; YETLEY, ELIZABETH A. 1; RADER, JEANNE I. 2; Affiliations: 1: Office of Special Nutritionab, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204; 2: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204; Issue Info: Mar96 Supplement, p765S; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: fortification; Author-Supplied Keyword: health claims; Author-Supplied Keyword: neural tube defects; Author-Supplied Keyword: public policy; Number of Pages: 8p; Document Type: Article; Language: Spanish
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SHANK, FRED R.
AU - CARSON, KAREN
AU - GLINSMANH, WALTER H.
T1 - Putting Things in Perspective: Building on Our Experience.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996/03/02/Mar96 Supplement
M3 - Article
SP - 781S
EP - 787S
SN - 00223166
AB - The science and policy underlying food labeling and food fortification have evolved over the past 30 years to a point where dietary guidance and nutrition labeling now provide consumers with highly sophisticated, very specific information about links be tween diet and health. The focus was once on preven tion of nutrient deficiency diseases, but today it is on reducing the risk of chronic diseases and health-re lated conditions. The Nutrition Labeling and Education Act of 1990, with its provisions for authorization of health claims on food labels, has provided a gateway through which a broader realm of nutrition and health information can be made available to consumers. How ever, the interpretation and implementation of the health claim provisions must evolve, based on a strong foundation of supporting science, so that industry may more readily make health information available to con sumers in a form that is easily understood and effec tively used in making their dietary choices. We must develop a database to support claims of beneficial ef fects of food components. We must be assured that the beneficial effects are not outweighed by safety con cerns. And we must develop an environment that is conducive to conducting the research to develop these data. This can only be accomplished through the col laborative efforts of industry, academia, consumers and public health agencies. J. Nutr. 126: 7818- 787S, 1996. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - folic acid
KW - food fortification
KW - food labeling
KW - health claims
N1 - Accession Number: 89382817; SHANK, FRED R. 1,2; CARSON, KAREN 1; GLINSMANH, WALTER H. 1; Affiliations: 1: Food and Drug Administration, U.S. Department of Health and Human Services, Washington, DC 20204; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204; Issue Info: Mar96 Supplement, p781S; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: food fortification; Author-Supplied Keyword: food labeling; Author-Supplied Keyword: health claims; Number of Pages: 7p; Document Type: Article; Language: Spanish
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Singh, GopaI K.
AU - Yu, Stella M.
T1 - US Childhood Mortality, 1950 through 1993: Trends and Socioeconomic Differentials.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/04//
VL - 86
IS - 4
M3 - Article
SP - 505
EP - 512
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined trends and differentials in US childhood mortality from 1950 through 1993 according to sex, race/ethnicity, education, family income, and cause of death. Methods. Log-linear, multiple regression, and Cox proportional hazards regression models were applied to the data from the National Vital Statistics System, the National Longitudinal Mortality Study; and the Area Resource File. Results. Substantial declines in US childhood mortality have occurred in the past 4 decades, primarily due to decreases in mortality from unintentional injuries, cancer, pneumonia and influenza, and congenital anomalies. The overall declining trend, however, has been dampened by a twofold to threefold increase in the suicide and homicide rates among children since 1968. Male, Black, American Indian, Hawaiian, and Puerto Rican children and those in the lower socioeconomic strata were at an increased risk of death. conclusions. Increasing trends in mortality from violence, firearm injuries, and human immunodeficiency virus / acquired immunodeficiency syndrome pose a major obstacle to continued declines in US childhood mortality. Reducing socioeconomic disparities and improving access to and use of health care may bring about further declines in overall and injury-related childhood mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Child mortality -- Statistics
KW - Mortality
KW - Statistics
KW - Medical statistics
KW - Medical care
KW - Child health services
KW - United States
N1 - Accession Number: 9605102313; Singh, GopaI K. 1; Yu, Stella M. 2; Affiliations: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md.; 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; Issue Info: Apr96, Vol. 86 Issue 4, p505; Subject Term: Child mortality -- Statistics; Subject Term: Mortality; Subject Term: Statistics; Subject Term: Medical statistics; Subject Term: Medical care; Subject Term: Child health services; Subject: United States; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Trends and Differentials in Adolescent and Young Adult Mortality in the United States, 1950 through 1993.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/04//
VL - 86
IS - 4
M3 - Article
SP - 560
EP - 564
PB - American Public Health Association
SN - 00900036
AB - Using data from the National Vital Statistics System and the National Longitudinal Mortality Study, this study examined mortality trends and differentials from 1950 through 1993 among US adolescents and young adults according to sex, race! ethnicity, education, family income, marital status, and cause of death. No appreciable reduction in youth mortality has occurred, especially among men. Declines in youth mortality from accidents have been nearly offset by increases in death rates from homicide, suicide, and firearm injuries. American Indians, Blacks. males, and those with least education and income were at increased risk of both overall and injury-specific youth mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical statistics
KW - Mortality -- Statistics
KW - Teenagers
KW - Death -- Causes -- Statistics
KW - Vital statistics
N1 - Accession Number: 9605102338; Singh, Gopal K. 1; Yu, Stella M. 2; Affiliations: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md.; 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockviile, Md.; Issue Info: Apr96, Vol. 86 Issue 4, p560; Subject Term: Medical statistics; Subject Term: Mortality -- Statistics; Subject Term: Teenagers; Subject Term: Death -- Causes -- Statistics; Subject Term: Vital statistics; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107926063
T1 - 'The First Step in Diabetes Meal Planning': A Case Presentation.
AU - Broussard, Brenda
Y1 - 1996/04//
N1 - Accession Number: 107926063. Language: English. Entry Date: 20140103. Revision Date: 20150712. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913432.
KW - Diabetes Mellitus -- Diet Therapy
KW - Diabetic Diet -- Education
KW - Diabetic Patients -- Education
KW - Adult
KW - Female
KW - Food Guide Pyramid
KW - Menu Planning -- Education
KW - Patient Centered Care
KW - Nurse-Patient Relations
SP - 103
EP - 105
JO - Diabetes Spectrum
JF - Diabetes Spectrum
JA - DIABETES SPECTRUM
VL - 9
IS - 2
CY - Alexandria, Virginia
PB - American Diabetes Association
SN - 1040-9165
AD - Nutrition consultant, Indian Health Service Diabetes Program, Albuquerque, NM
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Ellenberg, S
T1 - The use of data monitoring committees in clinical trials
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1996/04//Apr-Jun 1996
VL - 30
IS - 2
M3 - Article
SP - 553
EP - 557
SN - 00928615
AB - This paper provides an overview of the role of data monitoring committees in ensuring patient safety and validity and scientific merit of the trial. This more formalized data monitoring approach tends to be used only in trials where there is a lot at stake. Use of data monitoring committees at the National Institute of Health and results of a workshop held on the subject are discussed.
KW - ASSOCIATIONS, institutions, etc
KW - Data
KW - Drug information
KW - Monitoring
N1 - Accession Number: ISTA3101619; Ellenberg, S 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: Apr-Jun 1996, Vol. 30 Issue 2, p553; Note: Update Code: 3100; Subject Term: ASSOCIATIONS, institutions, etc; Author-Supplied Keyword: Data; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Monitoring; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 107387699
T1 - International perspective. Rebuilding in Rwanda: about nurses and nursing.
AU - Lambert MI
Y1 - 1996/04//1996 Apr
N1 - Accession Number: 107387699. Language: English. Entry Date: 19961101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9500156.
KW - Health Care Delivery -- Rwanda
KW - Nursing Practice -- Rwanda
KW - Rwanda
SP - 84
EP - 86
JO - Home Health Focus
JF - Home Health Focus
JA - HOME HEALTH FOCUS
VL - 2
IS - 11
CY - New York, New York
PB - Elsevier Science
SN - 1075-2188
AD - U.S. Public Health Service, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107380089
T1 - Databases -- their use in developing clinical practice guidelines and estimating the cost impact of guideline implementation.
AU - Edinger S
AU - McCormick KA
Y1 - 1996/04//1996 Apr
N1 - Accession Number: 107380089. Language: English. Entry Date: 19960901. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Computer/Information Science; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 9202024.
KW - Cost Benefit Analysis
KW - Practice Guidelines -- Standards
KW - Reference Databases, Health
KW - Outcomes Research
KW - United States Agency for Healthcare Research and Quality
SP - 52
EP - 60
JO - Journal of AHIMA
JF - Journal of AHIMA
JA - J AHIMA
VL - 67
IS - 4
CY - Chicago, Illinois
PB - American Health Information Management Association
SN - 1060-5487
AD - US Public Health Service, Agency for Health Care Policy and Research, Center for Information Technology, Rockville, MD
U2 - PMID: 10155782.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107391179
T1 - FDA update.
AU - Merkatz RB
Y1 - 1996/04//1996 Apr
N1 - Accession Number: 107391179. Language: English. Entry Date: 19961201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978.
KW - United States Food and Drug Administration
KW - Women's Health
KW - Mammography
KW - Sex Factors
KW - Clinical Trials
KW - Obesity -- Drug Therapy
KW - Acquired Immunodeficiency Syndrome -- Drug Therapy
KW - Skin Care
KW - Emollients
KW - Contraceptives, Oral
KW - Breast Self-Examination
KW - Dietary Fats
KW - Osteoporosis
KW - Calcium -- Therapeutic Use
SP - 97
EP - 101
JO - Journal of Women's Health
JF - Journal of Women's Health
JA - J WOMENS HEALTH
VL - 5
IS - 2
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1059-7115
AD - Office of Women's Health, Food and Drug Administration, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107379703
T1 - Workplace homicide: industries and occupations at high risk.
AU - Jenkins EL
Y1 - 1996/04//1996 Apr-Jun
N1 - Accession Number: 107379703. Language: English. Entry Date: 19960801. Revision Date: 20150711. Publication Type: Journal Article; research; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Homicide -- Epidemiology
KW - Work Environment
KW - Occupational-Related Injuries
KW - United States
KW - National Institute for Occupational Safety and Health
KW - Age Factors
KW - Occupations and Professions
KW - Industry
KW - Epidemiological Research
KW - Descriptive Statistics
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 219
EP - 225
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 11
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Homicide is to blame for 20 workplace deaths each week. Although no single intervention strategy will be appropriate in all situations, the author points out that interventions cannot be designed without knowledge of the demographic characteristics of victims and the distribution of workplace violence across industries and occupations. Such data are presented by gender, age, race, geographic distribution, method of homicide, and industry and occupation.
SN - 0885-114X
AD - National Institute for Occupational Safety and Health, HHH Building, Room 317-B, 200 Independence Ave, SW, Washington, DC 20201
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Qi Zheng
T1 - Risk Assessment of Nongenotoxic Carcinogens Based upon Cell Proliferation/Death Rates in Rodents.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1996/04//
VL - 16
IS - 2
M3 - Article
SP - 221
EP - 225
SN - 02724332
AB - Increased cell proliferation increases the opportunity for transformations of normal cells to malignant cells via intermediate cells. Nongenotoxic cytotoxic carcinogens that increase cell proliferation rates to replace necrotic cells are likely to have a threshold dose for cytotoxicity below which necrosis and hence, carcinogenesis do not occur. Thus, low dose cancer risk estimates based upon nonthreshold, linear extrapolation are inappropriate for this situation. However, a threshold dose is questionable if a nongenotoxic carcinogen acts via a cell receptor. Also, a nongenotoxic carcinogen that increases the cell proliferation rate, via the cell division rate and/or cell removal rate by apoptosis, by augmenting an existing endogenous mechanism is not likely to have a threshold dose. Whether or not a threshold dose exists for nongenotoxic carcinogens, it is of interest to study the relationship between lifetime rumor incidence and the cell proliferation rate. The Moolgavkar-Venzon-Knudson biologically based stochastic two-stage clonal expansion model is used to describe a carcinogenic process. Because the variability in cell proliferation rates among animals often makes it impossible to detect changes of less than 20% in the rate, it is shown that small changes in the cell proliferation rate, that may be obscured by the background noise in rates, can produce large changes in the lifetime tumor incidence as calculated from the Moolgavkar-Venzon-Knudson model. That is, dose response curves for cell proliferation and tumor incidence do not necessarily mimic each other. This makes the use of no observed effect levels (NOELs) for cell proliferation rates often inadmissible for establishing acceptable daily intakes (ADIs) of nongenotoxic carcinogens. In those cases where low dose linearity is not likely, a potential alternative to a NOEL is a benchmark dose corresponding to a small increase in the cell proliferation rate, e.g., 1%, to which appropriate safety (uncertainty) factors can be applied to arrive at an ADI. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Risk assessment
KW - Rodents
KW - Carcinogenicity
KW - Cell proliferation
KW - Mortality -- Statistics
KW - cell proliferation
KW - Moolgavkar-Venzon-Knudson model.
N1 - Accession Number: 11945359; Gaylor, David W. 1; Qi Zheng 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.; Issue Info: Apr96, Vol. 16 Issue 2, p221; Thesaurus Term: Carcinogens; Thesaurus Term: Risk assessment; Thesaurus Term: Rodents; Thesaurus Term: Carcinogenicity; Subject Term: Cell proliferation; Subject Term: Mortality -- Statistics; Author-Supplied Keyword: cell proliferation; Author-Supplied Keyword: Moolgavkar-Venzon-Knudson model.; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107328810
T1 - Reported complications of silicone gel breast implants: an epidemiologic review.
AU - Silverman BG
AU - Brown SL
AU - Bright RA
AU - Kaczmarek RG
AU - Arrowsmith-Lowe JB
AU - Kessler DA
Y1 - 1996/04/15/
N1 - Accession Number: 107328810. Language: English. Entry Date: 19970701. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Breast Implants -- Adverse Effects
KW - Silicones -- Adverse Effects
KW - Female
KW - Risk Factors
KW - United States
SP - 744
EP - 756
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 124
IS - 8
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 0003-4819
AD - Center for Devices and Radiological Health, HFZ-541, US Food and Drug Administration, 1350 Piccard Dr, Rockville, MD 20850
U2 - PMID: 8633836.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Weibel, Robert E.
AU - Benor, David E.
T1 - Reporting Vaccine-Associated Paralytic Poliomyelitis: Concordance between the CDC and the National Vaccine Injury Compensation Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/05//
VL - 86
IS - 5
M3 - Article
SP - 734
EP - 734
PB - American Public Health Association
SN - 00900036
AB - This paper compares cases of paralytic poliomyelitis reported to the systems operated by the National Vaccine Injury Compensation Program and the Centers for Disease Control and Prevention (CDC) for reporting of adverse events associated with vaccination. Of the 118 cases of vaccine-associated paralytic poliomyelitis determined by either system, 18 were reported initially only to the compensation program, 50 only to the CDC, and 50 to both. The annual incidence of vaccine-associated paralytic poliomyelitis determined from data from both systems varied from 6 to 13 cases (mean = 9.1) a year, with an increase of 1.4 cases a year when initial reports only to the compensation program are included. Thus, the compensation program provides important supplemental incidence data. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Communicable diseases -- Prevention
KW - Immunization
KW - Public health
KW - Poliomyelitis vaccine
KW - Polio -- Prevention
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 9606201951; Weibel, Robert E. 1; Benor, David E. 2; Affiliations: 1: National Vaccine Injury Compensation Program, Health Resources and Services Administration, Rockville, Md; 2: Office, General Counsel, US Department of Health and Human Services, Rockville, Md; Issue Info: May96, Vol. 86 Issue 5, p734; Thesaurus Term: Vaccination; Thesaurus Term: Communicable diseases -- Prevention; Thesaurus Term: Immunization; Thesaurus Term: Public health; Subject Term: Poliomyelitis vaccine; Subject Term: Polio -- Prevention; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morrow-Howell, Nancy
AU - Chadiha, Letha A.
AU - Proctor, Enola K.
AU - Hourd-Bryant, Maggie
AU - Dore, Peter
T1 - RACIAL DIFFERENCES IN DISCHARGE PLANNING.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1996/05//
VL - 21
IS - 2
M3 - Article
SP - 131
EP - 131
PB - Oxford University Press / USA
SN - 03607283
AB - Given previously reported findings of racial differences in elderly people's use of posthospital care, this article focuses on discharge planning processes as explanations of differential service utilization. We studied the discharge plans for 369 African American and white elderly patients and examined options pursued for posthospital care by social workers, patients, and families for evidence of racial differences. We also looked for racial differences in ruling out nursing home care for reasons of patient and family preference. Discharge planning with African American patients and family members involved less pursuit of nursing home care and more pursuit of formal services in the home than planning with white patients and families. Implications for practice and future research are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health & Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISCRIMINATION in medical care
KW - RACE discrimination
KW - HEALTH facilities -- Discharge planning
KW - AFRICAN Americans
KW - OLDER people
KW - NURSING home care
KW - African Americans
KW - discharge planning
KW - elderly people
KW - posthospital care
KW - racial differences
N1 - Accession Number: 9604261374; Morrow-Howell, Nancy 1; Email Address: nancymh@gwbssw.whstl.edu; Chadiha, Letha A. 2; Proctor, Enola K. 3,4; Hourd-Bryant, Maggie; Dore, Peter; Source Information: May1996, Vol. 21 Issue 2, p131; Subject: DISCRIMINATION in medical care; Subject: RACE discrimination; Subject: HEALTH facilities -- Discharge planning; Subject: AFRICAN Americans; Subject: OLDER people; Subject: NURSING home care; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: posthospital care; Author-Supplied Keyword: racial differences; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6076
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107383119
T1 - Gram-negative bacteremia in open-heart surgery patients traced to probable tap-water contamination of pressure-monitoring equipment.
AU - Rudnick JR
AU - Beck-Sague CM
AU - Anderson RL
AU - Schable B
AU - Miller JM
AU - Jarvis WR
Y1 - 1996/05//1996 May
N1 - Accession Number: 107383119. Language: English. Entry Date: 19961001. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Gram-Negative Bacterial Infections
KW - Bacteremia
KW - Coronary Artery Bypass
KW - Cross Infection -- Epidemiology
KW - Hospitals
KW - Monitoring, Direct Pressure -- Equipment and Supplies
KW - Equipment Contamination
KW - Infection Control -- Methods
KW - Epidemiological Research
KW - Gram-Negative Bacteria
KW - Prospective Studies
KW - Case Control Studies
KW - Disease Outbreaks
KW - Centers for Disease Control and Prevention (U.S.)
KW - Data Analysis Software
KW - Odds Ratio
KW - Confidence Intervals
KW - Fisher's Exact Test
KW - Adult
KW - Middle Age
KW - Aged
KW - Inpatients
KW - Male
KW - Female
KW - Human
SP - 281
EP - 285
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 17
IS - 5
PB - Cambridge University Press
AB - OBJECTIVE: To determine the cause(s) of an outbreak of gram-negative bacteremia (GNB) in openheart-surgery (OHS) patients at hospital A. DESIGN: Case-control and cohort studies and an environmental survey. RESULTS: Nine patients developed GNB with Enterobacter cloacae (6), Pseudomonas aeruginosa (5), Klebsiella pneumoniae (3), Serratia marcescens (2), or Klebsiella oxytoca (1) following OHS; five of nine patients had polymicrobial bacteremia. When the GNB patients were compared with randomly selected OHS patients, having had the first procedure of the day (8 of 9 versus 12 of 27, P=.02), longer cardiopulmonary bypass (median, 122 versus 83 minutes, P=.01) or cross-clamp times (median, 75 versus 42 minutes, P=.008), intraoperative dopamine infusion (9 of 9 versus 15 of 27, P=.01), or exposure to scrub nurse 6 (6 of 9 versus 4 of 27, P=.001) were identified as risk factors. When stratified by length of the procedure, only being the first procedure of the day and exposure to scrub nurse 6 remained significant. First procedures used pressure-monitoring equipment that was assembled before surgery and left open and uncovered overnight in the operating room, whereas other procedures used pressure-monitoring equipment assembled immediately before the procedure. At night, operating rooms were cleaned by maintenance personnel who used a disinfectant-water solution sprayed through a hose connected to an automatic diluting system. Observation of the use of this hose documented that this solution could have contacted and entered uncovered pressure-monitoring equipment left in the operating room. Water samples from the hose revealed no disinfectant, but grew P aeruginosa. The outbreak was terminated by setting up pressure-monitoring equipment immediately before the procedure and discontinuing use of the hose-disinfectant system. CONCLUSIONS: This outbreak most likely resulted from contamination of uncovered preassembled pressure-monitoring equipment by water from a malfunctioning spray disinfectant device. Pressure-monitoring equipment should be assembled immediately before use and protected from possible environmental contamination.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia
U2 - PMID: 8727616.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Franzblau, Alfred
AU - Rock, Cheryl L.
AU - Werner, Robert A.
AU - Albers, James W.
AU - Kelly, Matthew P.
AU - Johnston, Elizabeth C.
T1 - The Relationship of Vitamin B6 Status to Median Nerve Function and Carpal Tunnel Syndrome Among Active Industrial Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/05//
M3 - Article
SP - 485
EP - 491
SN - 00961736
AB - Case reports and small case series suggest that vitamin B6 deficiency is an important etiologic factor in carpal tunnel syndrome (CTS). This hypothesis has never been examined in a randomly selected study population, particularly among active workers. We examined 125 randomly selected active workers from two industrial plants. Each worker completed a self-administered symptom questionnaire and underwent electrodiagnostic testing of the median and ulnar sensory nerves. Laboratory biochemical analyses of vitamin B6 status were also performed using the erythrocyte glutamic pyruvic transaminase assay, and quantification of plasma pyridoxal-5' phosphate. Measurements of vitamin B6 status were unrelated to self-reported symptoms potentially consistent with CTS, electrophysiologically determined median or ulnar nerve function, and CTS defined on the basis of self-reported symptoms and electrophysiologic measurements. These results suggest that CTS among active industrial workers is unrelated to vitamin B6 status. Furthermore, in our opinion, empiric prescription of vitamin B6 to patients with CTS is unwarranted and potentially hazardous. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379605; Franzblau, Alfred 1; Rock, Cheryl L. 1; Werner, Robert A. 1; Albers, James W. 1; Kelly, Matthew P. 1; Johnston, Elizabeth C. 1; Source Information: May1996, p485; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4285
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Shaddock, J.G.
AU - Chou, M.W.
AU - Casciano, D.A.
T1 - Effects of age and caloric restriction on cell proliferation in hepatocyte cultures from control and hepatectomized Fischer 344 rats.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 1996/05//
VL - 11
IS - 3
M3 - Article
SP - 281
EP - 284
PB - Oxford University Press / USA
SN - 02678357
AB - The effects of age and caloric restriction on cell proliferation, measured as scheduled DNA synthesis (SDS), were evaluated in primary hepatocyte cultures from control and partially hepatectomized (PH) young to old ad libitum (AL) and caloric-restricted (CR) male Fischer 344 (F344) rats. We reported significant age- or CR-related decreases in SDS in control cultures. PH-induced cultures exhibited significant increases in SDS compared with their control counterparts. Hepatocytes from PH-induced old CR diet-fed animals exhibited significant increases in SDS compared with cultures from control old CR, PH-induced young CR and PH-induced old AL animals. Alternatively, SDS rates for PH-induced young CR animals were significantly lower at 48 h and higher at 72 h than the rates we reported for cultures from PH-induced young AL F344 rats. These data suggest that CR decreases and preserves the proliferative capacity in hepatocytes from young animals and may permit animals to respond more efficiently with induced compensatory cellular replication in old age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hydrogen-ion concentration
KW - Cell division (Biology)
KW - Liver cells
KW - Cell proliferation
KW - Low-calorie diet
KW - Rats as laboratory animals
KW - DNA synthesis
N1 - Accession Number: 79237795; Shaddock, J.G. 1; Chou, M.W. 2; Casciano, D.A. 1,3; Affiliations: 1: Divisions of Genetic Toxicology, National Center for Toxicological Research Jefferson, AR 72079; 2: Divisions of Nutritional Toxicology, National Center for Toxicological Research Jefferson, AR 72079; 3: University of Arkansa for Medical Sciences, Departments of Biochemistry and Molecular Biology and Toxicology Little Rock, AR 72205, USA; Issue Info: May1996, Vol. 11 Issue 3, p281; Thesaurus Term: Hydrogen-ion concentration; Thesaurus Term: Cell division (Biology); Subject Term: Liver cells; Subject Term: Cell proliferation; Subject Term: Low-calorie diet; Subject Term: Rats as laboratory animals; Subject Term: DNA synthesis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107352963
T1 - Tuberculosis surveillance using death certificate data, New York City, 1992.
AU - Washko RM
AU - Frieden TR
Y1 - 1996/05//May/Jun96
N1 - Accession Number: 107352963. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Tuberculosis, Pulmonary -- Mortality
KW - Disease Surveillance -- Methods
KW - Record Review
KW - Documentation
KW - New York
KW - Registries, Disease
KW - Tuberculosis, Pulmonary -- Epidemiology
KW - Chi Square Test
KW - Fisher's Exact Test
KW - Confidence Intervals
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 251
EP - 255
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 111
IS - 3
PB - Sage Publications Inc.
AB - OBJECTIVE. To determine the accuracy and frequency of reporting tuberculosis as either the contributing or underlying cause of death on death certificates in New York City during 1992. METHODS. Death certificates from 1992 that listed tuberculosis were matched with the New York City tuberculosis registry. For those persons who had tuberculosis listed as a cause of death, but who were not listed in the registry, medical records were reviewed. The frequency of reporting tuberculosis on death certificates in patients who died with active tuberculosis was evaluated in the second part of this study. Death certificates of patients with active tuberculosis (persons who died within six months of starting anti-tuberculosis medications) in 1992 were reviewed. RESULTS. Tuberculosis was listed on 635 death certificates; 377 (59%) were confirmed cases based on registry data. Reviews of medical records were possible for 230 (89%) of the remaining 258 patients and confirmed only two additional tuberculosis cases. Of 310 persons who died with active tuberculosis in 1992 (second part of the study), only 104 (34%) had tuberculosis listed on their death certificates. CONCLUSIONS. In New York City, a diagnosis of tuberculosis on death certificates is an inaccurate measure of tuberculosis burden.
SN - 0033-3549
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Clinical Investigations Branch, Room H-009, Morgantown, WV 26505; e-mail rmw8@niords1.em.cdc.gov
U2 - PMID: 8643817.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105853006
T1 - The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina.
AU - Sullivan EA
AU - Kamb ML
AU - Jones JL
AU - Meyer P
AU - Philen RM
AU - Falk H
AU - Sinks T
Y1 - 1996/05/13/
N1 - Accession Number: 105853006. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Eosinophilia-Myalgia Syndrome -- Chemically Induced
KW - Eosinophilia-Myalgia Syndrome -- Mortality
KW - Eosinophilia-Myalgia Syndrome -- Pathology
KW - Drug Contamination
KW - Female
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Tryptophan -- Adverse Effects
KW - Human
SP - 973
EP - 979
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 156
IS - 9
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Ga, USA.
U2 - PMID: 8624177.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Moore, S. R.;
T1 - Importance of public health in the next century
CT - Importance of public health in the next century
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 1996/05/15/
VL - 53
IS - May 15
SP - 1200
EP - 1203
SN - 10792082
AD - Office of the Surgeon General, Public Hlth. Serv., Rockville, MD 20857, USA
N1 - Accession Number: 33-11581; Language: English; References: 1; Publication Type: Letters; Journal Coden: AHSPEK; Section Heading: Pharmacy Practice; Sociology, Economics and Ethics; Abstract Author: Elvira deC. Weiss
N2 - The important role of public health in the new order of health care delivery is discussed, including the pharmacists' role in public health services. The various activities of pharmacists in primary and secondary prevention, and the steps in implementing a public health pharmacy service are also described.
KW - Pharmacists--role--public health;
KW - Public health--pharmacists--role;
KW - Pharmacy services--public health--pharmacists role;
KW - Health care--pharmacists--role;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Doll, Lynda S.
AU - Beeker, Carolyn
T1 - MALE BISEXUAL BEHAVIOR AND MY RISK IN THE UNITED STATES: SYNTHESIS OF RESEARCH WITH IMPLICATIONS FOR BEHAVIORAL INTERVENTIONS.
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 1996/06//
VL - 8
IS - 3
M3 - Article
SP - 205
EP - 225
SN - 08999546
AB - The article reports on the result of the study on the relationship between HIV risk and male bisexual behavior in the U.S. According to the authors, male bisexuality presents the greatest HIV risk in the context of male prostitution, intravenous drug abuse, sexual identity exploration and culturally specific gender roles and norms. The complex patterns of bisexual behavior could not be easily described. Among the 2,020 interviewed men with AIDS 17 percent of them claimed to have sexual contact with both men and women in the last five years. The study shows that 12 percent of bisexual men are more likely to have used injecting drugs than homosexual men.
KW - AIDS (Disease)
KW - HIV infections
KW - HIV-positive bisexual men
KW - HIV-positive men
KW - Bisexual men
KW - Bisexuality
KW - Intravenous drug abusers
KW - Prostitution
KW - United States
N1 - Accession Number: 19720693; Doll, Lynda S. 1; Beeker, Carolyn 1; Affiliations: 1: HIV, STD, & Tuberculosis Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Public Health Service,Department of Health and Human Services, Atlanta,GA.; Issue Info: Jun1996, Vol. 8 Issue 3, p205; Thesaurus Term: AIDS (Disease); Subject Term: HIV infections; Subject Term: HIV-positive bisexual men; Subject Term: HIV-positive men; Subject Term: Bisexual men; Subject Term: Bisexuality; Subject Term: Intravenous drug abusers; Subject Term: Prostitution; Subject: United States; Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107336399
T1 - Male bisexual behavior and HIV risk in the United States: synthesis of research with implications for behavioral interventions.
AU - Doll LS
AU - Beeker C
Y1 - 1996/06//
N1 - Accession Number: 107336399. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9002873.
KW - Bisexuality
KW - Men
KW - HIV Infections -- Transmission
KW - Risk Taking Behavior
KW - Male
KW - Risk Factors
KW - Sexual Partners
KW - Gender Identity
KW - Gender Role
KW - Ethnic Groups
KW - Substance Abuse, Intravenous
KW - HIV Infections -- Prevention and Control
KW - Behavioral Changes
KW - HIV Education
KW - Female
KW - Prostitution
KW - Adolescence
KW - Adult
SP - 205
EP - 225
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
JA - AIDS EDUC PREV
VL - 8
IS - 3
CY - New York, New York
PB - Guilford Publications Inc.
AB - This paper reviews recent literature on male bisexuality and HIV risk and suggests new directions for intervention and research in the United States. AIDS case reports and behavioral studies based on convenience samples suggest that behaviorally bisexual men use condoms inconsistently with male and female partners, seldom disclose their bisexuality to their female partners, and are more likely than exclusively homosexual men to report multiple HIV risk behaviors. Male bisexuality may present greatest HIV risk in the context of (a) male prostitution, (b) injecting drug use, (c) sexual identity exploration, and (d) culturally specific gender roles and norms such as those that may characterize some African American and Hispanic communities in the United States. We review individual and community level interventions to reach men within these four contexts as well as the larger population of bisexual men. We also suggest a heuristic model to encourage additional research examining multiple dimensions of bisexual behavior and HIV risk.
SN - 0899-9546
AD - HIV, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA
U2 - PMID: 8806950.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107277429
T1 - SAFE questions: overcoming barriers to the detection of domestic violence.
AU - Neufeld B
Y1 - 1996/06//6/1/1996
N1 - Accession Number: 107277429. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Domestic Violence -- Diagnosis
KW - Domestic Violence -- Epidemiology
KW - Physician Attitudes
KW - Domestic Violence -- Symptoms
KW - Domestic Violence -- Therapy
SP - 2575
EP - 2580
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 53
IS - 8
CY - Skokie, Illinois
PB - American Academy of Family Physicians
AB - Although domestic violence is an important public health problem in this country, several barriers tend to hinder its detection by physicians. Physicians may lack knowledge about the subject, harbor attitudes that hinder detection or lack the necessary skills to address patients who are victims of domestic violence. The SAFE questions--which address the areas of safety, abuse, friends' and family's knowledge and emergency plans--can be used to identify affected patients. In addition, these questions provide the physician with a logical framework for counseling and intervention.
SN - 0002-838X
AD - San Xavier Health Center, Indian Health Service, 7900 SJ Stock Rd, Tucson, AZ 85746
U2 - PMID: 8644571.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Adverse Pregnancy Outcomes: Differences Between US- and Foreign-Born Women in Major US Racial and Ethnic Groups.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Article
SP - 837
EP - 837
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined whether there were significant differentials between US-born and foreign-born women in risks of infant mortality, low birthweight, and preterm birth and whether these differentials, if they existed, varied across major US racial/ethnic groups. Methods. Multivariate logistic regression was applied to national linked birth/infant death records for 1985 through 1987 to estimate overall and ethnic-specific maternal nativity effects on pregnancy outcomes. Results. Substantial maternal nativity differences in risks of infant mortality and low birthweight were found, with the magnitude of the nativity effect varying significantly across racial/ethnic groups. Overall, foreign-born status was associated with 7% and 20% lower risks of low birthweight and infant mortality, respectively. However, the reduced risk of adverse pregnancy outcome associated with immigrant status tended to be substantially larger for Blacks, Cubans, Mexicans, and Chinese than for other ethnic groups. Conclusions. Maternal nativity status, along with ethnicity, may serve as an important axis of differentiation in birth outcome studies. Further research needs to be conducted to assess the effects of behavioral, cultural, and psychosocial factors in explaining the nativity differentials observed here. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Labor complications (Obstetrics)
KW - Infant mortality
KW - Low birth weight
KW - Premature labor
KW - Women
KW - United States
N1 - Accession Number: 9607016047; Singh, Gopal K. 1; Yu, Stella M. 2; Affiliations: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md; 2: Bureau of Maternal and Child Health, Health Resources and Services Administration, Rockvillle, Md; Issue Info: Jun96, Vol. 86 Issue 6, p837; Subject Term: Labor complications (Obstetrics); Subject Term: Infant mortality; Subject Term: Low birth weight; Subject Term: Premature labor; Subject Term: Women; Subject: United States; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hall, H. Irene
AU - Haugh, Gilbert S.
AU - Price-Green, Patricia A.
AU - Dhara, V. Ramana
AU - Kaye, Wendy E.
T1 - Risk Factors for Hazardous Substance Releases that Result in Injuries and Evacuations: Data From 9 States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Article
SP - 855
EP - 855
PB - American Public Health Association
SN - 00900036
AB - This study was undertaken to determine risk factors associated: with hazardous substance releases (at fixed facilities or during transport) that have public health consequences. Data from nine states with surveillance systems for such releases and their consequences were analyzed. Risk factors were determined for releases resulting in (1) injuries or (2) evacuations. Both outcomes were more likely to occur as a result of facility releases (odds ratio [OR] = 1.89,95% confidence interval (CI] = 1.44, 2.47 for injuries; OR = 3.29, 95% CI = 2.28, 4.74, for evacuations). Releases of ammonia, chlorine, and acids resulted in injuries and evacuations more frequently than releases of other substances. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Health risk assessment
KW - Wounds & injuries
KW - Public health
KW - United States
N1 - Accession Number: 9607016062; Hall, H. Irene 1; Haugh, Gilbert S. 2; Price-Green, Patricia A. 1; Dhara, V. Ramana 1; Kaye, Wendy E. 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Ga; 2: The Orkand Corp, Atlanta; Issue Info: Jun96, Vol. 86 Issue 6, p855; Thesaurus Term: Hazardous substances; Thesaurus Term: Health risk assessment; Thesaurus Term: Wounds & injuries; Thesaurus Term: Public health; Subject: United States; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Bright, Roselie A.
AU - Moore Jr., Roscoe M.
T1 - Estimating the prevalence of women with breast implants.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Letter
SP - 891
EP - 891
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "The Estimated Frequency of Cosmetic Breast Augmentation Among U.S. Women, 1963 Through 1988," by M. B. Terry, M. L. Skovron and E. Sonnenschein in the 1995 issue of the "American Journal of Public Health," including a response from the authors.
KW - Letters to the editor
KW - Augmentation mammaplasty
N1 - Accession Number: 19893510; Bright, Roselie A. 1; Moore Jr., Roscoe M. 2; Affiliations: 1: Office of Surveillance and Biometrics, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Md; 2: Office of International Affairs, US Department of Health and Human Services, Rockville, Md; Issue Info: Jun96, Vol. 86 Issue 6, p891; Subject Term: Letters to the editor; Subject Term: Augmentation mammaplasty; Number of Pages: 3/4p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sundaresan, P. R.
AU - Kaup, Susan M.
AU - Wiesenfeld, Paddy W.
AU - Chirtel, Stuart J.
AU - Hight, Susan C.
AU - Rader, Jeanne I.
T1 - Interactions in indices of vitamin A, zinc and copper status when these nutrients are fed to rats at adequate and increased levels.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 1996/06//
VL - 75
IS - 6
M3 - Article
SP - 915
EP - 928
SN - 00071145
AB - The purpose of the present study was to determine the effects of feeding nutritionally adequate and increased levels of vitamin A (retinyl acetate at 1·4, 34·4, and 206·4 mg/kg diet) in combination with adequate or increased Zn (12 and 240 mg/kg) and Cu (5 and 50mg/kg) on serum and tissue concentrations of retinol and retinyl palmitate and on indices of Cu and Zn status in female Sprague–Dawley rats, and to measure interactive effects of such nutrient imbalances. Rats fed on diets containing 34·4 and 206·4 mg vitamin A/kg had higher feed intakes and relative Liver weights than those fed on diets containing 1.4mg vitamin A/kg. An interaction between dietary Cu and Zn and an independent effect of vitamin A affected serum ceruloplasmin oxidase (EC 1.16.3.1) activity. Rats fed on high Zn, adequate-Cu diets (240 and 5 mg Zn and Cu/kg respectively) had lower serum ceruloplasmin oxidase levels than rats fed on adequate-Zn, adequate-Cu diets (12 and 5 mg Zn and Cu/kg respectively). This effect was not observed in rats fed on high-Zn, high-Cu diets (240 and 50mg Zn and Cu/kg respectively). Alterations in dietary levels of Cu and vitamin A independently affected haemoglobin levels. Serum cholesterol concentration was affected by interactions between Zn and vitamin A and Cu and vitamin A. Levels of retinol and retinyl palmitate in liver and kidney were significantly higher in rats fed on diets with increased dietary vitamin A than in those fed on diets with adequate vitamin A. Three-way interactions among Cu, Zn, and vitamin A affected levels of retinol in serum and liver. Two-way interactions between Cu and vitamin A affected liver retinyl palmitate and the sum of liver retinol + retinyl palmitate. An independent effect of dietary Zn on these variables was also observed. Interactions between Cu and vitamin A affected levels of Cu in liver and kidney, while Fe and Zn in kidney were affected by interactions between Cu and Zn. This study demonstrates that differing interactions among variables of vitamin A metabolism and mineral status occur with higher dietary levels of vitamin A, Zn and Cu in the rat [ABSTRACT FROM PUBLISHER]
AB - Copyright of British Journal of Nutrition is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Copper
KW - Nutrient interactions
KW - Vitamin A
KW - Zinc
N1 - Accession Number: 56701534; Sundaresan, P. R. 1; Kaup, Susan M. 1; Wiesenfeld, Paddy W. 1; Chirtel, Stuart J. 2; Hight, Susan C. 3; Rader, Jeanne I. 4; Affiliations: 1: Office of Special Nutritionals, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; 2: Office of Scientific Analysis and Support Center for Food Safety and Applied Nutrition, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; 3: Office of Plant and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; 4: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; Issue Info: Jun1996, Vol. 75 Issue 6, p915; Author-Supplied Keyword: Copper; Author-Supplied Keyword: Nutrient interactions; Author-Supplied Keyword: Vitamin A; Author-Supplied Keyword: Zinc; Number of Pages: 14p; Document Type: Article
L3 - 10.1079/BJN19960197
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Driskell, W. J.
AU - Hill, Jr., R. H.
AU - Shealy, D. B.
AU - Hull, R. D.
AU - Hines, C. J.
T1 - Identification of a Major Human Urinary Metabolite of Alachlor by LC-MS/MS.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1996/06//
VL - 56
IS - 6
M3 - Article
SP - 853
EP - 859
SN - 00074861
AB - The article discusses the study that identifies a major human urinary metabolite of alachlor, a preemergence herbicide commonly used on soybeans, by LC-MS/MS. According to sources, alachlor metabolites have been identified in monkey urine and found to be mainly thioethers, while human alachlor exposure has commonly been estimated by quantifying the hydrolysis product, 2,6-diethylaniline (DEA), of alachlor metabolites in urine. Based from the study, a major human metabolite of alachor was identified, known as alachlor mercapturate. The researchers also developed a method to measure alachlor mercapturate in urine, and compared levels of the metabolite to levels of DEA, which is the hydrolysis product of alachlor metabolites, in urine samples from people exposed to alachlor.
KW - Alachlor
KW - Herbicides
KW - Metabolites
KW - Biological products
KW - Chemical ecology
KW - Hydrolysis
KW - Diethylaniline
KW - Urinalysis
KW - Monkeys as laboratory animals
N1 - Accession Number: 15730210; Driskell, W. J. 1; Hill, Jr., R. H. 1; Shealy, D. B. 1; Hull, R. D. 2; Hines, C. J. 2; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA; 2: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Cincinnati, Ohio 45242, USA; Issue Info: Jun96, Vol. 56 Issue 6, p853; Thesaurus Term: Alachlor; Thesaurus Term: Herbicides; Thesaurus Term: Metabolites; Thesaurus Term: Biological products; Thesaurus Term: Chemical ecology; Thesaurus Term: Hydrolysis; Subject Term: Diethylaniline; Subject Term: Urinalysis; Subject Term: Monkeys as laboratory animals; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 07p; Illustrations: 2 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104790107
T1 - Powerful hands: making the most of graduate medical education.
AU - Mullan, F
Y1 - 1996///Summer1996
N1 - Accession Number: 104790107. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Education, Medical -- Economics
KW - Medicare -- Administration
KW - Training Support, Financial
KW - Physicians
KW - United States
SP - 250
EP - 253
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 15
IS - 2
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
SN - 0278-2715
AD - U.S. Department of Health and Human Services, Health Resources and Services Administration, USA.
U2 - PMID: 8690381.
DO - 10.1377/hlthaff.15.2.250
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ore, Timothy
AU - Casini, Virgil
T1 - Electrical Fatalities Among U.S. Construction Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/06//
M3 - Article
SP - 587
EP - 592
SN - 00961736
AB - Over 2000 electrocution deaths were identified among U.S. construction workers from 1980 to 1991, with the highest mean annual crude mortality rate (2.5 per 100,000 people), and second highest mean age-adjusted rate (2.7 per 100,000 people) of all industries. Although the crude fatality rates showed a downward trend, construction workers are still about four times more likely to be electrocuted at work than are workers in all industries combined. Nearly 40% of the 5083 fatal electrocutions in all industries combined occurred in construction, and 80% were associated with industrial wiring, appliances, and transmission lines. Electrocutions ranked as the second leading cause of death among construction workers, accounting for an average of 15% of traumatic deaths in the industry from 1980 to 1991. The study indicates that the workers most at risk of electrical injury are male, young, nonwhite, and electricians, structural metal workers, and laborers. The most likely time of injury is 11 a.m. to 3 p.m. from June to August. Focusing prevention on these populations and characteristics through better methods of worker and supervisor electrical safety training, use of adequate protective clothing, and compliance with established procedures could minimize the average annual loss of 168 U.S. construction workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379585; Ore, Timothy 1; Casini, Virgil 1; Source Information: Jun1996, p587; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3440
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Wilt, Jeffrey L.
AU - Banks, Daniel E.
AU - Weissman, David N.
AU - Parker, John E.
AU - Vallyathan, Val
AU - Castranova, Vincent
AU - Dedhia, Harakh V.
AU - Stulken, Edward
AU - Ma, Joseph K.H.
AU - Ma, Jane Y.C.
AU - Cruzzaval, Jose
AU - Shumaker, Jennifer
AU - Childress, Charles P.
AU - Lapp, N. LeRoy
T1 - Reduction of Lung Dust Burden in Pneumoconiosis by Whole-Lung Lavage.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/06//
M3 - Article
SP - 619
EP - 624
SN - 00961736
AB - Pneumoconioses are characterized as irreversible, progressive respiratory diseases. No effective therapy exists to prevent progression of these diseases. Whole-lung lavage (WLL) might limit the rate of disease progression through the removal of dust, inflammatory cells, and cytokines. We performed WLL on a 54-year-old underground miner employed as a motorman and roof bolter and a 55-year-old driller at a surface coal mine. Both demonstrated normal lung function and chest radiographs showing ILO profusion category 2 nodular interstitial changes. From Subject 1, we recovered 5.24 x 108 cells (90% macrophages) from the right lung and 3.45 x 108 cells (94% macrophages) from the left lung. WLL removed 1.82 g of mineral dust (non-coal) on the right and 1.64 g on the left. From Subject 2, we recovered 7.49 x 108 cells (46% macrophages) from the right and 9.78 x 108 cells (69% macrophages) from the left lung. WLL removed 0.40 g of mineral dust on the right and 0.53 g on the left. Proinflammatory cytokines, growth factors, and cellular enzymes were also recovered. In cases of pneumoconiosis, WLL is capable of removing relatively large quantities of dust, cells, and soluble materials from the lungs. Only long-term follow-ups of individuals with progressive dust-induced disease who receive WLL therapy in the context of a clinical trial will provide information regarding the importance of removing mineral dust and inflammatory cells from the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379590; Wilt, Jeffrey L. 1; Banks, Daniel E. 1; Weissman, David N. 1; Parker, John E. 1; Vallyathan, Val 1; Castranova, Vincent 1; Dedhia, Harakh V. 1; Stulken, Edward 1; Ma, Joseph K.H. 1; Ma, Jane Y.C. 1; Cruzzaval, Jose 1; Shumaker, Jennifer 1; Childress, Charles P. 1; Lapp, N. LeRoy 1; Source Information: Jun1996, p619; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3980
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Gaylort, David W.
AU - Chen, James J.
T1 - A Simple Upper Limit for the Sum of the Risks of the Components in a Mixture.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1996/06//
VL - 16
IS - 3
M3 - Article
SP - 395
EP - 398
SN - 02724332
AB - Natural or manufactured products may contain mixtures of carcinogens and the human environment certainly contains mixtures of carcinogens. Various authors have shown that the total risk of a mixture can be approximated by the sum of the risks of the individual components under a variety of conditions at low doses. Under these conditions, summing the individual estimated upper bound risks, as currently often done, is too conservative because it is unlikely that all risks for a mixture are at their maximum levels simultaneously. In the absence of synergism, a simple procedure is proposed for estimating a more appropriate upper bound of the additive risks for a mixture of carcinogens. These simple limits also apply to noncancer endpoints when the risks of the components are approximately additive. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Human ecology
KW - Natural products
KW - Manufactures
KW - Risk
KW - Guidelines
N1 - Accession Number: 11839250; Gaylort, David W. 1; Chen, James J. 1; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.; Issue Info: Jun96, Vol. 16 Issue 3, p395; Thesaurus Term: Carcinogens; Thesaurus Term: Human ecology; Thesaurus Term: Natural products; Subject Term: Manufactures; Subject Term: Risk; Subject Term: Guidelines; NAICS/Industry Codes: 339999 All Other Miscellaneous Manufacturing; NAICS/Industry Codes: 339990 All other miscellaneous manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter, Clark D.
T1 - Trust in Numbers: The Pursuit of Objectivity in Science and Public Life (Book).
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1996/06//
VL - 16
IS - 3
M3 - Book Review
SP - 440
EP - 441
SN - 02724332
AB - Reviews the book "Trust in Numbers: The Pursuit of Objectivity in Science and Public Life," by Thomas M. Porter
KW - Science
KW - Nonfiction
KW - Porter, Thomas M.
KW - Trust in Numbers (Book)
N1 - Accession Number: 11839257; Porter, Clark D. 1; Affiliations: 1: Center of Food Safety and Applied Nutrition, Department of Health and Human Service, FDA, 200 C Street S.W., HFS-308, Washington, D.C. 20204.; Issue Info: Jun96, Vol. 16 Issue 3, p440; Subject Term: Science; Subject Term: Nonfiction; Reviews & Products: Trust in Numbers (Book); People: Porter, Thomas M.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105856052
T1 - Medical shortage designation. A federal intervention that works.
AU - Arrindell ER
AU - Ruck JM
Y1 - 1996/06//
N1 - Accession Number: 105856052. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0410504.
KW - Health Services Accessibility -- Trends
KW - Medically Underserved Area
KW - Primary Health Care -- Manpower
KW - United States
SP - 537
EP - 538
JO - Western Journal of Medicine
JF - Western Journal of Medicine
JA - WEST J MED
VL - 164
IS - 6
PB - BMJ Publishing Group
SN - 0093-0415
AD - Division of Shortage Designation, Bureau of Primary Health Care, Health Resources and Services Administration, Bethesda, Maryland 20814, USA.
U2 - PMID: 8764639.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1996-05369-002
AN - 1996-05369-002
AU - Doll, Lynda S.
AU - Beeker, Carolyn
T1 - Male bisexual behavior and HIV risk in the United States: Synthesis of research with implications for behavioral interventions.
JF - AIDS Education and Prevention
JO - AIDS Education and Prevention
Y1 - 1996/06//
VL - 8
IS - 3
SP - 205
EP - 225
CY - US
PB - Guilford Publications
SN - 0899-9546
N1 - Accession Number: 1996-05369-002. PMID: 8806950 Partial author list: First Author & Affiliation: Doll, Lynda S.; US Dept of Health & Human Services, Public Health Service, Ctrs for Disease Control & Prevention, Atlanta, GA, US. Release Date: 19960101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Bisexuality; HIV; Human Males; Risk Taking. Minor Descriptor: Gender Identity; Intravenous Drug Usage; Prostitution; Racial and Ethnic Differences; Sex Roles. Classification: Immunological Disorders (3291). Population: Human (10); Male (30). Methodology: Literature Review. Page Count: 21. Issue Publication Date: Jun, 1996.
AB - Reviews literature on male bisexuality and HIV risk and suggests new directions for intervention and research in the US. AIDS case reports and behavioral studies based on convenience samples suggest that behaviorally bisexual men use condoms inconsistently with male and female partners, seldom disclose their bisexuality to their female partners, and are more likely than exclusively homosexual men to report multiple HIV risk behaviors. Male bisexuality may present greatest HIV risk in the context of (1) male prostitution, (2) injecting drug use, (3) sexual identity exploration, and (4) culturally specific gender roles and norms such as those that may characterize some African American and Hispanic communities in the US. Individual and community level interventions are reviewed to reach men within these 4 contexts as well as the larger population of bisexual men. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - male prostitution & injecting drug use & sexual identity & culturally specific gender norms & roles
KW - risk for HIV
KW - bisexual males
KW - individual & community intervention implications
KW - 1996
KW - At Risk Populations
KW - Bisexuality
KW - HIV
KW - Human Males
KW - Risk Taking
KW - Gender Identity
KW - Intravenous Drug Usage
KW - Prostitution
KW - Racial and Ethnic Differences
KW - Sex Roles
KW - 1996
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17620-058
AN - 2004-17620-058
AU - Hurrell, Joseph J. Jr.
T1 - Job stress: A complex yet timely subject.
JF - Contemporary Psychology
JO - Contemporary Psychology
Y1 - 1996/06//
VL - 41
IS - 6
SP - 613
EP - 614
CY - US
PB - American Psychological Association
SN - 0010-7549
N1 - Accession Number: 2004-17620-058. Other Journal Title: PsycCRITIQUES. Partial author list: First Author & Affiliation: Hurrell, Joseph J. Jr.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20040927. Correction Date: 20170130. Publication Type: Electronic Collection (0500). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Occupational Stress. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Reviewed Item: Crandall, Rick (Ed); Perrewe, Pamela L. (Ed). Occupational Stress: A Handbook=Philadelphia: Taylor & Francis, 1995. 307 pp; 1995. References Available: Y. Page Count: 2. Issue Publication Date: Jun, 1996.
AB - Occupational Stress: A Handbook (Crandall and Perrewe; see record [rid]1995-97235-000[/rid]) offers the reader a valuable guide to understanding the increasingly important and complex topic of occupational stress. The book is divided into five parts dealing with job stress theory, model testing, moderators of the stress-health relationship, burnout, and job stress interventions. Each part contains chapters by noted job stress researchers and, by and large, the chapters are well written. In summary, I believe that the reader will find this book to be interesting and useful. It should be of particular value to empirical researchers seeking a compendium of current knowledge regarding the constructs, theories, and methods of job stress research. The book is likely, however, to disappoint the practitioner seeking definitive solutions to the increasingly important and costly problem of job stress. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - job stress
KW - occupational stress
KW - 1996
KW - Occupational Stress
KW - 1996
U2 - Crandall, Rick (Ed); Perrewe, Pamela L. (Ed). (1995); Occupational Stress: A Handbook; Philadelphia: Taylor & Francis, 1995. 307 pp; 1-56032-367-1.
DO - 10.1037/002989
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DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Harkins, R D
T1 - Uses of laboratory data in anti infective drug approval processes
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1996/07//Jul-Sep 1996
VL - 30
IS - 3
M3 - Article
SP - 811
EP - 813
SN - 00928615
AB - Laboratory data represents a largely unused body of data in the drug approval process. Such data, when properly collected and used, can provide invaluable insights into drug efficacy and safety in subgroups of the target population. The Statistical Evaluation and Research Branch's use of these data for these two purposes uncovered several problems. These include the lack of standard nomenclature and terminology, properly established reference intervals, and documented auditing methods plus doubts about the validity of data due to lack of proof of good laboratory practices (GLP). There were errors in computerization of data that adversely affected evaluation and interpretation of these data.
KW - AUTOMATIC data collection systems
KW - Drug information
KW - Laboratories
KW - Pharmacy
N1 - Accession Number: ISTA3102757; Harkins, R D 1; Affiliations: 1 : US Food and Drug Administration, Rockville, MD; Source Info: Jul-Sep 1996, Vol. 30 Issue 3, p811; Note: Update Code: 3100; Subject Term: AUTOMATIC data collection systems; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Laboratories; Author-Supplied Keyword: Pharmacy; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
AU - Amandus, H. E.
AU - Zahm, D.
AU - Friedmann, R.
AU - Ruback, R. B.
AU - Block, C.
AU - Weiss, J.
AU - Rogan, D.
AU - Holmes, W.
AU - Bynum, T.
AU - Hoffman, D.
AU - McManus, R.
AU - Malcan, J.
AU - Wellford, C.
AU - Kessler, D.
T1 - Employee Injuries and Convenience Store Robberies in Selected Metropolitan Areas.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/07//
M3 - Article
SP - 714
EP - 720
SN - 00961736
AB - The number of robberies and robbery-related injuries to employees in convenience stores (C-stores) during 1992 or 1993 were estimated for selected metropolitan areas around Miami and Tampa, Florida; Atlanta, Georgia; Chicago, Illinois; Baltimore, Maryland; Boston, Massachusetts; Detroit, Michigan; Pittsburgh and Philadelphia, Pennsylvania; Charleston, Columbia, Greenville, and Spartanburg, South Carolina; and Arlington, Chesterfield, and Henrico counties, Virginia. Of the 1835 C-store robberies that occurred during 1992 or 1993 in all selected areas (excluding Atlanta and Chicago), there were 12 homicides of C-store employees; 219 nonfatal injuries of C-store employees; 1071 robberies in which there were no injuries but a weapon was used, displayed, or implied toward a C-store employee; and 132 robberies in which there was no injury and no weapon used, but an employee was struck, pushed, or shoved. Corresponding figures for the 238 robberies that occurred in Chicago during January to June 1993, and for which victim employment status was unknown (customer or employee) were three homicides, 53 nonfatal injuries, 120 attacks in which a weapon was used but there was no injury, and 57 attacks in which a person was struck, pushed, or shoved but there was no injury. The proportion of robberies that resulted in a homicide or injury to an employee varied among selected areas from .03 to .25. The proportion of homicides and injuries to an employee was .14 or higher for target areas in Baltimore (.24), Detroit (.25), and Virginia (.14); the proportion to an employee or customer was .24 in Chicago. The conclusions from these data are that the risk of employee injury in C-store robberies was high in selected metropolitan areas. This underscores the need for effective robbery prevention programs to reduce injury. In addition, further research is needed to determine the effectiveness of present prevention programs in the C-store industry and the application of these programs to other retail industries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379572; Amandus, H. E. 1; Zahm, D. 1; Friedmann, R. 1; Ruback, R. B. 1; Block, C. 1; Weiss, J. 1; Rogan, D. 1; Holmes, W. 1; Bynum, T. 1; Hoffman, D. 1; McManus, R. 1; Malcan, J. 1; Wellford, C. 1; Kessler, D. 1; Source Information: Jul1996, p714; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4278
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107382145
T1 - Mycology III: mycology and indoor air quality.
AU - Hung L
Y1 - 1996/07//1996 Jul
N1 - Accession Number: 107382145. Language: English. Entry Date: 19960901. Revision Date: 20150819. Publication Type: Journal Article; CEU; glossary; pictorial; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0250641.
KW - Fungi
KW - Air Pollution, Indoor
KW - Education, Continuing (Credit)
KW - Mycoses
KW - Fungi -- Adverse Effects
KW - Microbiological Techniques
SP - 454
EP - 461
JO - Laboratory Medicine
JF - Laboratory Medicine
JA - LAB MED
VL - 27
IS - 7
PB - Oxford University Press / USA
AB - Fungi are widespread in our environment. During the past decade, concern has increased about the quality of air at home, in workplaces, and in public buildings. Although fungi should not grow indoors owing to potential health problems, many cases of fungal contamination in indoor environments exist. Outdoor fungal propagules enter homes and buildings through doors; windows; heating, ventilation, and air-conditioning systems; and the clothing and footwear of occupants. Fungal spores, metabolites, and mycotoxins have affected the health of some individuals. The laboratorian should be aware of fungal contamination in indoor environments. This is the final article in a three-part series on mycology. Other articles discussed poisonous mushrooms and mycotic opportunists in the immunocompromised patient. Following this series, readers should be able to identify the eight general mushroom poison types and their various characteristics, identify common mycotic opportunists, and understand the investigation and control of fungal contamination in indoor environments.
SN - 0007-5027
AD - US Public Health Service, Division of Federal Occupational Health, 3535 Market St, Room 1310, Philadelphia, PA 19104, e-mail: Lhung@phsphi.ssw.dhhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107382149
T1 - Should laboratories test for toxin A-negative, toxin B-positive Clostridium difficile?
AU - Altaie SS
AU - Penque PH
AU - Mookherjee S
AU - Evans DT
Y1 - 1996/07//1996 Jul
N1 - Accession Number: 107382149. Language: English. Entry Date: 19960901. Revision Date: 20150819. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0250641.
KW - Clostridium Difficile
KW - Bacterial Toxins -- Analysis
KW - Diagnostic Errors
KW - Prevalence
KW - Immunoassay
KW - Feces -- Analysis
KW - Diagnosis, Laboratory
KW - In Vitro Studies
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Human
SP - 468
EP - 471
JO - Laboratory Medicine
JF - Laboratory Medicine
JA - LAB MED
VL - 27
IS - 7
PB - Oxford University Press / USA
AB - We evaluated 300 stool specimens from patients suspected of having Clostridium difficile-associated diarrhea to determine the prevalence of toxin A-negative, toxin B-positive C difficile isolates. Each specimen was cultured anaerobically on selective media using the heat-shock method and screened for C difficile toxins by two enzyme immunoassays -- one that uses an anti-toxin A monoclonal antibody and one that uses a mixture of an anti-toxin A and an anti-toxin B monoclonal. The C difficile strains isolated from specimens were retested for production of toxin B by a tissue culture assay and for production of toxin A by a second toxin A immunoassay. Thirty-two specimens were positive and 234 specimens were negative for an assays. Thirty-four specimens had discrepant results. After discrepancy analysis, all of the isolated difficile strains were determined to be either nontoxigenic (producing neither of the toxins) or toxigenic (producing both toxins). These data indicate that the prevalence of toxin A-negative, toxin B-positive strains of C difficile is not of concern in routine diagnostic testing for C difficile toxins in our study population.
SN - 0007-5027
AD - Center for Drug Evaluation and Research, Division of Anti-infective Drug Products, Attn: Document Control Room, 5600 Fishers Lane, HFD-520, Rockville, MD 20857, e-mail: altaies@cder.fda.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Koch, Walter H.
AU - Henrikson, Erik N.
AU - Cebula, Thomas A.
T1 - Molecular analyses of Salmonella hisG428 ochre revertants for rapid characterization of mutational specificity.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 1996/07//
VL - 11
IS - 4
M3 - Article
SP - 341
EP - 348
PB - Oxford University Press / USA
SN - 02678357
AB - The Salmonella typhimurium tester strains TA104 and TA102 were developed primarily to aid in the detection of oxidative mutagens and other agents that react preferentially with AT base pairs. Reversion to prototrophy of strains harboring the hisG428 ochre allele can occur by (i) any of seven single base substitutions or (ii) several tandem double base substitutions at the ochre codon, (iii) in-frame deletions removing all or part of the ochre codon or (iv) mutations at several distinct tRNA extragenic suppressor loci. We have used allele-specific oligonucleotide probes and DNA sequence analysis to characterize 625 revertants of strain TA104 (hisG428, rfa, ΔuvrB/pKM101) arising spontaneously or after treatment with methyl methanesulfonate, glyoxal, streptonigrin or angelicin with UVA radiation. The reversion profiles obtained from these analyses distinguished readily each of the mutagentreated populations from one another and from spontaneously derived revertants. Both GC and AT base pairspecific revertants were observed. Molecular analyses of S.typhimurium hisG428 revertants permitted rapid assessment of base pair substitution specificity of mutagens, especially the detection of AT base pair substitutions not recovered in strains carrying the complementary hisG46 allele. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutagens
KW - Molecular microbiology
KW - Salmonella typhimurium
KW - Alleles
KW - Methyl methanesulfonate
KW - Nucleotide sequence
KW - Nucleic acid probes
N1 - Accession Number: 79237806; Koch, Walter H.; Henrikson, Erik N.; Cebula, Thomas A. 1; Affiliations: 1: Food and Drug Administration Center for Food Safety and Applied Nutrition, Molecular Biology Branch 200 C St SW (HFS-237). Washington, DC 20204, USA; Issue Info: Jul1996, Vol. 11 Issue 4, p341; Thesaurus Term: Mutagens; Thesaurus Term: Molecular microbiology; Subject Term: Salmonella typhimurium; Subject Term: Alleles; Subject Term: Methyl methanesulfonate; Subject Term: Nucleotide sequence; Subject Term: Nucleic acid probes; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107352625
T1 - Interpretation and use of occupational exposure limits for chronic disease agents.
AU - Hewett P
Y1 - 1996/07//1996 Jul-Sep
N1 - Accession Number: 107352625. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Occupational Diseases
KW - Occupational Exposure
KW - Chronic Disease
KW - Health Education
KW - Models, Statistical
KW - Occupational Diseases -- Epidemiology
KW - Occupational Diseases -- Prevention and Control
KW - Occupational Health
KW - Risk Assessment
KW - Risk Management
SP - 561
EP - 590
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 11
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - This article discusses occupational exposure limits for chronic disease agents both as a product of occupational exposure risk assessment and as an essential component of occupational exposure risk management.
SN - 0885-114X
AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Environmental Investigations Branch, 1095 Willowdale Road, Morgantown, WV 26505-2888
U2 - PMID: 8887385.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107383098
T1 - Predict and prevent pressure ulcers.
AU - Kamerow DB
Y1 - 1996/07//1996 Jul
N1 - Accession Number: 107383098. Language: English. Entry Date: 19960901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; USA. NLM UID: 8608563.
KW - Pressure Ulcer -- Prevention and Control
KW - Practice Guidelines
SP - 63
EP - 64
JO - Provider
JF - Provider
JA - PROVIDER
VL - 22
IS - 7
CY - Washington, District of Columbia
PB - American Health Care Association
SN - 0888-0352
AD - Office of the Forum for Quality and Effectiveness in Health Care, Agency for Health Care Policy and Research, Public Health Service, U.S. Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288379
T1 - Local research: needed guidance for the Indian Health Services's urban mission... Trauma among American Indians in an urban county.
AU - Nolan LJ
AU - Freeman WL
AU - D'Angelo AJ
Y1 - 1996/07//Jul/Aug96
N1 - Accession Number: 107288379. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Native Americans -- Washington
KW - Health Services Needs and Demand
KW - Urban Health -- Washington
KW - Health Services, Indigenous -- Administration
KW - Washington
KW - Trauma -- Ethnology
SP - 320
EP - 320
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 111
IS - 4
PB - Sage Publications Inc.
SN - 0033-3549
AD - Indian Health Service
U2 - PMID: 8711097.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288377
T1 - Trauma among American Indians in an urban county.
AU - Sugarman JR
AU - Grossman DC
Y1 - 1996/07//Jul/Aug96
N1 - Accession Number: 107288377. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by Grant No. R49/CCR002570 from the Centers for Disease Control and Prevention. NLM UID: 9716844.
KW - Trauma -- Ethnology
KW - Native Americans
KW - Urban Health
KW - Trauma -- Epidemiology
KW - Epidemiological Research
KW - Retrospective Design
KW - Record Review
KW - Incidence
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Chi Square Test
KW - Logistic Regression
KW - Odds Ratio
KW - Statistical Significance
KW - Trauma Centers
KW - Hospitalization
KW - Alcoholic Intoxication
KW - Age Factors
KW - Assault and Battery
KW - Wounds, Stab
KW - Homelessness
KW - Washington
KW - Adult
KW - Middle Age
KW - Inpatients
KW - Male
KW - Female
KW - Funding Source
KW - Human
SP - 321
EP - 327
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 111
IS - 4
PB - Sage Publications Inc.
AB - Objective. To describe severe injury among American Indians in a large metropolitan county given that most previous studies of the high Indian injury morbidity and mortality rates have been conducted primarily in rural areas. Methods. A retrospective analysis of a hospital trauma registry was conducted for the years 1986-92 at the Harborview Medical Center, the only Level I trauma center in King County, Washington, a metropolitan county with the seventh largest number of urban American Indians in the United States. Results. Of 14,851 King County residents included in the registry, 593 (4%) were classified as American Indian. With King County whites as the reference, the age standardized incidence ratio for inclusion of American Indians in the registry was 4.4 (95% confidence interval 4.1, 4.8). The standardized incidence ratios and proportional incidence ratios showed significant differences in mechanism and whether it was intentional or unintentional among Indians compared with whites. Hospitalizations for stab wounds, bites, and other blunt trauma were all significantly more frequent among Indians. Trauma admissions among Indians were disproportionately associated with assaults. A high proportion (72.3%) of American Indians tested had blood alcohol levels exceeding 0.1%. Conclusion. Urban American Indians experience high rates of trauma, differing from those among whites. Efforts to reduce injury in urban areas should include collaboration with representative urban American Indian organizations.
SN - 0033-3549
AD - Research from: Division of Research Evaluation, and Epidemiology, Portland Area Indian Health Service, Seattle, WA 98133-9075; e-mail: sugarman@u.washington.edu
U2 - PMID: 8711098.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Data Quality of the Drug Abuse Warning Network.
AU - Roberts, Charles DeWitt
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1996/08//
VL - 22
IS - 3
SP - 389
EP - 401
SN - 00952990
N1 - Accession Number: 9610294244; Author: Roberts, Charles DeWitt: 1 email: CROBERTS@SAMHSA.GOV. ; Author Affiliation: 1 Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Suite 618, Rockwall II, Rockville, Maryland 20857.; No. of Pages: 13; Language: English; Publication Type: Article; Update Code: 20050912
N2 - The purpose of this article was to assess the quality of data collected by the Drug Abuse Warning Network (DAWN), which reports drug abuse emergency department visits. The results of quality assurance studies at 36 sites were reviewed and interpreted. Data collection procedures are not consistent among hospitals and, along with personnel, regularly change within a hospital. Trained investigators reabstracted DAWN report forms at 24 sites and determined that only 57.4% of the cases that met DAWN case definition criteria had been reported; one of five cases had been reported at one site. The technique used in 11 (47.8%) of 23 hospitals to screen for potential DAWN cases detected only 36% of the cases found when all medical charts are examined. The investigators found discrepancies between reported and actual cases in 81.3% of the report forms reabstracted, with an average of 2.3 errors per form. Information as to the drug(s) involved was incorrect in 36.3% of the forms. Due to underreporting of drug abuse emergency department visits and poor quality data in DAWN report forms, DAWN estimates of drug activity must be viewed with caution. Furthermore, estimation of trends is risky, due to differences between emergency departments as to reporting systems and changes over time. ABSTRACT FROM AUTHOR
KW - *DRUG abuse
KW - *SUBSTANCE abuse
KW - *ALCOHOLISM
KW - *DRUG use testing
KW - VICTIMLESS crimes
KW - DRUGGED driving
KW - Alcohol abuse
KW - DAWN
KW - Emergency department
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107381815
T1 - Legislation. US Food and Drug Administration proposes federal regulation of labeling of latex-containing medical devices.
AU - Kedas AM
AU - Dillard S
AU - Tomazic V
Y1 - 1996/08//1996 Aug
N1 - Accession Number: 107381815. Language: English. Entry Date: 19960901. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 0372403.
KW - Product Labeling -- Legislation and Jurisprudence
KW - United States Food and Drug Administration
KW - Latex
KW - Surgical Equipment and Supplies
KW - Legislation
KW - Consumer Product Safety
KW - Hypersensitivity -- Prevention and Control
KW - United States
SP - 290
EP - 292
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 64
IS - 2
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - US Food and Drug Administration, Rockville, Md
U2 - PMID: 8853787.
DO - 10.1016/S0001-2092(06)63158-X
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hoekstra, Edward J.
AU - Kiefer, Max
AU - Tepper, Allison
T1 - Monitoring of Exposure to Benomyl in Nursery Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/08//
M3 - Article
SP - 775
EP - 781
SN - 00961736
AB - We compared urinary levels of the metabolite methyl-5-hydroxy-2-benzimidazole carbamate (5-HBC) among nursery workers exposed to the fungicide benomyl (specifically Benlate 50 DF® [DuPont, Wilmington, DE]) and workers not exposed to benomyl. Environmental exposures were quantitated from gloves, body patches, and air samples collected with area and personal monitors. The median concentration of 5-HBC in the urine of benomyl-exposed workers was 23.8 µmol of 5-HBC per mole of creatinine. No 5-HBC was detected in the reference group. Industrial hygiene results and biological monitoring findings indicate that use of Benlate 50 DF® in the ornamental industry can lead to absorption of the active ingredient, benomyl. Weighing, mixing, and application activities involved the highest exposures. Dermal contact appeared to be the primary route of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379548; Hoekstra, Edward J. 1; Kiefer, Max 1; Tepper, Allison 1; Source Information: Aug1996, p775; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4192
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107380694
T1 - Guide to medical devices. How to report medical-device problems.
AU - Reynolds CT
Y1 - 1996/08//
N1 - Accession Number: 107380694. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety -- Legislation and Jurisprudence
KW - Mandatory Reporting
KW - Government Regulations
KW - United States Food and Drug Administration
KW - Legislation -- United States
KW - United States
SP - 24u
EP - v
JO - Nursing
JF - Nursing
JA - NURSING
VL - 26
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105854944
T1 - Monitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess.
AU - Ward EM
AU - Sabbioni G
AU - DeBord DG
AU - Teass AW
AU - Brown KK
AU - Talaska GG
AU - Roberts DR
AU - Ruder AM
AU - Streicher RP
Y1 - 1996/08/07/
N1 - Accession Number: 105854944. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089.
KW - Air Pollution, Indoor -- Adverse Effects
KW - Air -- Analysis
KW - Amines -- Analysis
KW - Bladder Neoplasms -- Epidemiology
KW - Carcinogens -- Analysis
KW - Environmental Monitoring -- Methods
KW - Occupational Exposure -- Adverse Effects
KW - Amines -- Adverse Effects
KW - Amines -- Urine
KW - Bladder Neoplasms -- Chemically Induced
KW - Carcinogens -- Adverse Effects
KW - Incidence
KW - Industry
KW - Rubber
SP - 1046
EP - 1052
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
JA - J NATL CANCER INST
VL - 88
IS - 15
PB - Oxford University Press / USA
SN - 0027-8874
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
U2 - PMID: 8683635.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Burnett, Carol A.
AU - Boeniger, Mark F.
AU - Johnson, Jeffrey
T1 - Neurodegenerative Diseases: Occupational Occurrence and Potential Risk Factors, 1982 through 1991.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/09//
VL - 86
IS - 9
M3 - Article
SP - 1281
EP - 1288
PB - American Public Health Association
SN - 00900036
AB - Objectives. To identify potential occupational risk factors, this study examined the occupational occurrence of various neurodegenerative diseases. Methods. Death certificates from 27 states in the National Occupational Mortality Surveillance System were evaluated for 1982 to 1991. Proportionate mortality ratios were calculated by occupation for presenile dementia, Alzheimer's disease, Parkinson's disease, and motor neuron disease. Results. Excess mortality was observed for all four categories in the following occupational categories: teachers; medical personnel; machinists and machine operators; scientists; writers/designers/entertainers; and support and clerical workers. Clusters of three neurodegenerative diseases were also found in occupations involving pesticides, solvents, and electromagnetic fields and in legal, library, social, and religious work. Early death from motor neuron disease was found for firefighters, janitors, military personnel, teachers, excavation machine operators, and veterinarians, among others. Conclusions. Neurodegenerative disease occurs more frequently in some occupations than in others, and this distribution, which may indicate occupational risk factors, should be further investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Occupational diseases
KW - Neurodegeneration
KW - RISK factors
KW - Presenile dementia
KW - Alzheimer's disease
KW - Parkinson's disease
KW - Motor neuron diseases
N1 - Accession Number: 9610020120; Schulte, Paul A. 1; Burnett, Carol A. 2; Boeniger, Mark F. 2; Johnson, Jeffrey 3; Affiliations: 1: Education and Information Division, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 3: Department of Health Policy and Management, Johns Hopkins University, Baltimore, Md.; Issue Info: Sep96, Vol. 86 Issue 9, p1281; Thesaurus Term: Diseases; Thesaurus Term: Occupational diseases; Subject Term: Neurodegeneration; Subject Term: RISK factors; Subject Term: Presenile dementia; Subject Term: Alzheimer's disease; Subject Term: Parkinson's disease; Subject Term: Motor neuron diseases; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 6845
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107353826
T1 - Neurodegenerative diseases: occupational occurrence and potential risk factors, 1982 through 1991.
AU - Schulte PA
AU - Burnett CA
AU - Boeniger MF
AU - Johnson J
Y1 - 1996/09//
N1 - Accession Number: 107353826. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Alzheimer's Disease -- Mortality
KW - Dementia, Presenile -- Mortality
KW - Parkinson Disease -- Mortality
KW - Occupational Health
KW - Alzheimer's Disease -- Epidemiology
KW - Blacks
KW - Whites
KW - Comparative Studies
KW - Record Review
KW - Dementia, Presenile -- Epidemiology
KW - Neuromuscular Diseases -- Epidemiology
KW - Parkinson Disease -- Epidemiology
KW - Risk Factors
KW - Sex Factors
KW - United States
KW - Confidence Intervals
KW - Mantel-Haenszel Test
KW - Chi Square Test
KW - Neuromuscular Diseases -- Mortality
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Human
SP - 1281
EP - 1288
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 86
IS - 9
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: To identify potential occupational risk factors, this study examined the occupational occurrence of various neurodegenerative diseases. METHODS: Death certificates from 27 states in the National Occupational Mortality Surveillance System were evaluated for 1982 to 1991. Proportionate mortality ratios were calculated by occupation for presenile dementia, Alzheimer's disease, Parkinson's disease, and motor neuron disease. RESULTS: Excess mortality was observed for all four categories in the following occupational categories: teachers; medical personnel; machinists and machine operators; scientists; writers/designers/entertainers; and support and clerical workers. Clusters of three neurodegenerative diseases were also found in occupations involving pesticides, solvents, and electromagnetic fields and in legal, library, social, and religious work. Early death from motor neuron disease was found for firefighters, janitors, military personnel, teachers, excavation machine operators, and veterinarians, among others. CONCLUSIONS: Neurodegenerative disease occurs more frequently in some occupations than in others, and this distribution, which may indicate occupational risk factors, should be further investigated.
SN - 0090-0036
AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
U2 - PMID: 8806381.
DO - 10.2105/AJPH.86.9.1281
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107353826&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107251962
T1 - Applying standardized electromagnetic compatibility testing methods for evaluating radiofrequency interference with ventilators.
AU - Casamento JP
AU - Ruggera PS
AU - Casamento, J P
AU - Ruggera, P S
Y1 - 1996/09//1996 Sep-Oct
N1 - Accession Number: 107251962. Language: English. Entry Date: 19980401. Revision Date: 20161117. Publication Type: journal article; tables/charts; tracings. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Ventilators, Mechanical
KW - Equipment Failure
KW - Radio
KW - Electromagnetic Fields
KW - Data Analysis Software
KW - Product Evaluation
SP - 418
EP - 425
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 30
IS - 5
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - FDA scientists identify the modulation that interferes most with the ventilator and determine the degree of RF susceptibility.
SN - 0899-8205
AD - FDA/CDRH, Rockville, MD 20857, USA
AD - Electrical Engineer, Center for Devices and Radiological Health, Mail Stop HFZ-133, 12721 Twinbrook Parkway, Rockville, MD 20857
U2 - PMID: 8909703.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107251962&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107209255
T1 - Developmental risk factors for childhood pedestrian injuries.
AU - Schieber RA
AU - Thompson NJ
Y1 - 1996/09//
N1 - Accession Number: 107209255. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Child Safety
KW - Walking -- Adverse Effects -- In Infancy and Childhood
KW - Child Development
KW - Accidents, Traffic -- Prevention and Control -- In Infancy and Childhood
KW - Child Behavior
KW - Perception -- In Infancy and Childhood
KW - Infant
KW - Child, Preschool
KW - Child
SP - 228
EP - 236
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 2
IS - 3
PB - BMJ Publishing Group
SN - 1353-8047
AD - National Center for Injury Prevention and Control, Centers for Disease Control and Prevention (CDC), US Public Health Service, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 9346096.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107337507
T1 - Dental caries, restoration and tooth conditions in US adults, 1988-1991... selected findings from the Third National Health and Nutrition Examination Survey.
AU - Brown LJ
AU - Winn DM
AU - White BA
Y1 - 1996/09//
N1 - Accession Number: 107337507. Language: English. Entry Date: 19970901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060.
KW - Dental Caries -- Epidemiology -- United States
KW - Tooth Diseases -- Epidemiology -- United States
KW - Crowns -- Evaluation
KW - Dentures -- Evaluation
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Female
KW - Male
KW - Sex Factors
KW - Race Factors
KW - Ethnic Groups
KW - Hispanics
KW - Age Factors
KW - Epidemiological Research
KW - Interrater Reliability
KW - Surveys
KW - Probability Sample
KW - Clinical Assessment Tools
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Control (Research)
KW - Prevalence
KW - Summated Rating Scaling
KW - Prospective Studies
KW - P-Value
KW - United States
KW - Human
SP - 1315
EP - 1325
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 127
IS - 9
CY - Chicago, Illinois
PB - American Dental Association
AB - This article provides estimates of dental caries experience and selected restorative and tooth conditions among U.S. adults, obtained from Phase 1 (1988-1991) of the Third National Health and Nutrition Examination Survey. Between 1988 and 1991, 94 percent of adults in the United States showed evidence of past or present coronal caries. Based on the data collected, the authors estimate that about 40.5 percent, or 61.6 million, dentate adults had at least one tooth or tooth space that could potentially benefit from professional treatment. Minimally, it is estimated that 135.6 million tooth or tooth spaces among U.S. adults may benefit from professional treatment. These estimates supplement information available from the DMF index to provide a broader profile of the impact of dental caries on permanent tooth of U.S. adults.
SN - 0002-8177
AD - Division of Epidemiology and Oral Disease Prevention, National Institute of Dental Research, National Institutes of Health, US Public Health Service, Bethesda, MD
U2 - PMID: 8854607.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107337507&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107323311
T1 - CDRH summary report. FDA summarizes radiation therapy device problems.
AU - Kaczmarek RV
Y1 - 1996///Fall1996
N1 - Accession Number: 107323311. Language: English. Entry Date: 19970501. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9206619.
KW - Radiotherapy -- Equipment and Supplies
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 143
EP - 144
JO - Radiation Therapist
JF - Radiation Therapist
JA - RADIAT THERAPIST
VL - 5
IS - 2
CY - Alburquerque, New Mexico
PB - American Society of Radiologic Technologists
SN - 1084-1911
AD - FDA's Center for Devices and Radiological Health
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miller, Kim S.
AU - Hennessy, Michael
AU - Wendell, Deborah A.
AU - Webber, Mayris P.
AU - Schoenbaum, Ellie E.
T1 - BEHAVIORAL RISKS FOR HIV INFECTION ASSOCIATED WITH HIV-TESTING DECISIONS.
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 1996/10//
VL - 8
IS - 5
M3 - Article
SP - 394
EP - 402
SN - 08999546
AB - The article focuses on the behavioral risks for HIV infection associated with HIV-testing decisions. It also uses two-stage regression methods to identify sexual behavior risk factors for the infection which is associated with the decision to accept the test. As part of a clinic-based research program on HIV/AIDS in New York City, adolescent and adult women were offered HIV testing. The authors of the article have concluded that voluntary HIV testing can identify women with behavioral risks of the infection, and that voluntary testing may be effective in targeting persons at high risk.
KW - AIDS (Disease)
KW - Communicable diseases
KW - Diseases
KW - HIV infections -- Risk factors
KW - RISK factors
KW - Diagnosis
KW - Human sexuality
KW - Medical research
KW - New York (N.Y.)
KW - New York (State)
N1 - Accession Number: 19720701; Miller, Kim S. 1; Hennessy, Michael 2; Wendell, Deborah A. 3; Webber, Mayris P. 4; Schoenbaum, Ellie E. 4; Affiliations: 1: Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA; 2: Division of STD Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA; 3: Louisiana Office of Public Health, New Orleans, LA; 4: Montefiore Medical Center, Albert Einstein College of Medicine, Epidemiology and Social Medicine, Bronx, NY; Issue Info: Oct1996, Vol. 8 Issue 5, p394; Thesaurus Term: AIDS (Disease); Thesaurus Term: Communicable diseases; Thesaurus Term: Diseases; Subject Term: HIV infections -- Risk factors; Subject Term: RISK factors; Subject Term: Diagnosis; Subject Term: Human sexuality; Subject Term: Medical research; Subject: New York (N.Y.); Subject: New York (State); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107327009
T1 - Comparative sporicidal effect of liquid chemical germicides on three medical devices contaminated with spores of Bacillus subtilis.
AU - Sagripanti J
AU - Bonifacino A
Y1 - 1996/10//1996 Oct
N1 - Accession Number: 107327009. Language: English. Entry Date: 19970601. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Product Evaluation
KW - Sterilization and Disinfection -- Methods
KW - Equipment Contamination -- Prevention and Control
KW - Quantitative Studies
KW - Bacillus
KW - Dental Equipment
KW - Catheters
KW - Comparative Studies
KW - Phenols
KW - Glutaraldehyde
KW - Hydrogen Peroxide
KW - Formaldehyde
KW - Sodium Hypochlorite
KW - Human
SP - 364
EP - 371
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 24
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - Background: The relatively limited variety of surfaces and geometries challenged in current sporicidal testing reduces the predictive value of these analyses when extrapolated to the wide variety of medical devices. The unknown spore load being challenged and the qualitative nature (growth/no growth) of those tests further prevent precise comparison among liquid chemical disinfectants. Hence, the relative activity of different chemical substances has not been clearly established, hindering selection of the best agent for each clinical situation. Methods: A micromethod was developed to assess sporicidal activity against Bacillus subtilis spores deposited on three different medical devices: carbon-steel dental burs, silicone-rubber medical catheters, and titanium-alloy dental abutment screws. The spore load on each device and the recovery after three analytical steps were quantitatively assessed with spores radiolabeled with carbon 14 methionine. Results: The killing of 2 to 7 x 10(6) spores loaded on three different devices and exposed to glutaraldehyde, formaldehyde, copper ascorbate, hydrogen peroxide, peracetic acid, sodium hypochlorite, or phenol for 30 minutes at 20 degrees C ranged from a 10(3)-fold decrease for 10% hydrogen peroxide to zero decrease for 5% phenol. Our results suggest that the nature of the surface being challenged may affect the sporicidal activity of some chemical agents. Conclusion: The quantitative data presented allow comparison of the sporicidal effect of different liquid chemical agents. These findings may help prevent an overestimation of sporicidal activity and possible transmission of pathogens from the surface of improperly decontaminated medical devices.
SN - 0196-6553
AD - Molecular Biology Branch, Center for Devices and Radiological Health, Food and Drug Administration, 5600 Fishers Ln, Rockville, MD 20857
U2 - PMID: 8902111.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107327009&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Fairweather, W R
T1 - Integrated safety analysis: statistical issues in the assessment of safety in clinical trials
JO - Drug Information Journal
JF - Drug Information Journal
Y1 - 1996/10//Oct-Dec 1996
VL - 30
IS - 4
M3 - Article
SP - 875
EP - 879
SN - 00928615
AB - The emphasis in this essay is on statistical issues in the assessment of safety, and in particular, in putting these issues in context. The present status and future goals for the assessment of safety are considered. This can only be understood in the context of the medical, biological, and economic setting of the future. Drug information in the year 2015 is discussed.
KW - Drug information
KW - Future
KW - Pharmacy
KW - Statistics
N1 - Accession Number: ISTA3200255; Fairweather, W R 1; Affiliations: 1 : Food and Drug Administration, Rockville, MD; Source Info: Oct-Dec 1996, Vol. 30 Issue 4, p875; Note: Update Code: 3200; Author-Supplied Keyword: Drug information; Author-Supplied Keyword: Future; Author-Supplied Keyword: Pharmacy; Author-Supplied Keyword: Statistics; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - lih
ER -
TY - JOUR
ID - 107306847
T1 - Epidemiology of work-related musculoskeletal disorders.
AU - Hales TR
AU - Bernard BP
Y1 - 1996/10//1996 Oct
N1 - Accession Number: 107306847. Language: English. Entry Date: 19970101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0254463.
KW - Musculoskeletal Diseases -- Epidemiology
KW - Occupational-Related Injuries -- Epidemiology
KW - Causal Attribution
KW - Incidence
KW - Prevalence
KW - Cumulative Trauma Disorders
KW - Low Back Pain
KW - Occupations and Professions
KW - Industry
KW - Risk Factors
KW - Arm
KW - Neck Injuries
KW - Neck
KW - Shoulder
KW - Occupational Exposure
KW - Elbow
KW - Tendinopathy
KW - Carpal Tunnel Syndrome
KW - Hand
KW - Wrist
KW - Stress, Psychological
KW - Work Environment
SP - 679
EP - 709
JO - Orthopedic Clinics of North America
JF - Orthopedic Clinics of North America
JA - ORTHOP CLIN NORTH AM
VL - 27
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0030-5898
AD - Medical Section, Hazard Evaluations and Technical Assistance Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio
U2 - PMID: 8823390.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107225684
T1 - Stress management in work settings: a critical review of the health effects.
AU - Murphy LR
Y1 - 1996/11//1996 Nov-Dec
N1 - Accession Number: 107225684. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 8701680.
KW - Stress Management
KW - Stress, Occupational -- Therapy
KW - Treatment Outcomes
KW - Stress, Occupational -- Complications
KW - Relaxation
KW - Biofeedback
KW - Meditation
KW - Cognitive Therapy
KW - Combined Modality Therapy
KW - Stress, Occupational -- Physiopathology
KW - Stress, Occupational -- Psychosocial Factors
SP - 112
EP - 135
JO - American Journal of Health Promotion
JF - American Journal of Health Promotion
JA - AM J HEALTH PROMOT
VL - 11
IS - 2
PB - Sage Publications Inc.
AB - Purpose. To review critically the research literature on the health effects of worksite stressmanagement interventions. Search Methods. Stress-management interventions were defined as techniques that are designed to help employees modify their appraisal of stressful situations or deal more effectively with the symptoms of stress. Stress-management studies that were worksite based, assessed a health outcome, and were published in the peer-reviewed literature were included in this review. The main search method was the one described in the lead article to this special issue of the journal, but supplementary sources included prior reviews of the research literature and expert contacts. Sixty-four studies met the criteria for inclusion in this review. Summary of Findings. A variety of stress-management techniques was used in worksite studies, including muscle relaxation, meditation, biofeedback, cognitive-behavioral skills, and combinations of these techniques. The most common techniques used were muscle relaxation, cognitivebehavioral skills, and combinations of two or more techniques. Outcome measures to evaluate the success of stress interventions included physiologic and psychologic measurements, somatic complaints, and job-related measures. Nearly three-fourths of the studies offered the training to all workers and did not specifically recruit high-stress employees. Over half the studies were randomized control trials, but only 30% conducted posttraining follow-up evaluations. The effectiveness of stress interventions varied according to the health-outcome measure used; some techniques were more effective for psychologic outcomes (e.g., cognitive-behavioral skills), whereas others were more effective for physiologic outcomes (e. g., muscle relaxation). Biofeedback was the Least frequent technique used in work settings and also seemed to be the least effective technique. Meditation produced the most consistent results across outcome measures but was used in only six studies. In general, studies using a combination of techniques (e.g., muscle relaxation plus cognitivebehavioral skills) seemed to be more effective across outcome measures than single techniques. Conclusions. The large number of different stress-management techniques coupled with the wide range of health outcome measures used in stress intervention studies makes it difficult to draw firm conclusions about the efficacy of each technique and each outcome. Also, the quality of the methodology varied substantially among studies. Nevertheless, the most positive results across the various health outcomes were obtained with a combination of two or more techniques. None of the stress interventions was consistently effective in producing effects on job/organization-relevant outcomes, such as absenteeism or job satisfaction. To produce changes on these types of measures, stress interventions will need to alter or modify the sources of stress in the work environment. It can be said that stress management in work settings can be effective in enhancing worker physical and psychologic health, but the choice of which stress-management technique to use should be based on the specific health outcomes that are targeted for change.
SN - 0890-1171
AD - National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, OH 45226
U2 - PMID: 10163598.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107144910
T1 - A clinical guide to using DMPA...depot medroxyprogesterone acetate
AU - Attico NB
AU - Billy MJ
Y1 - 1996/11//1996 Nov
N1 - Accession Number: 107144910. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8002229.
KW - Medroxyprogesterone
KW - Medroxyprogesterone -- Adverse Effects
KW - Female
SP - 53
EP - 67
JO - Family Practice Recertification
JF - Family Practice Recertification
JA - FAM PRACT RECERTIF
VL - 18
IS - 11
CY - Plainsboro, New Jersey
PB - Intellisphere, LLC
AB - Depot medroxyprogesterone acetate (DMPA) is becoming one of the more popular contraceptive agents in clinical use in the United States today. It is effective, safe, and relatively inexpensive when compared with other methods. Side effects include menstrual changes such as breakthrough bleeding and amenorrhea, weight gain, and androgenic effects. To avoid loss of bone density, supplemental calcium is recommended while the patient is using DMPA. Return to fertility is unpredictable but usually occurs within 9-12 months after stopping the drug. Counseling patients about the drug's actions and side effects will help assure compliance-and thus avoid unwanted pregnancies.
SN - 0163-6642
AD - Director, Maternal Child Health Program, Phoenix Area Indian Health Service, Phoenix, AZ
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Malkin, Robert
AU - Kiefer, Max
AU - Tolos, William
T1 - 1-Hydroxypyrene Levels In Coal-Handling Workers at a Coke Oven.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/11//
M3 - Article
SP - 1141
EP - 1144
SN - 00961736
AB - An environmental and medical survey was conducted at the coal-handling area of a coke oven, where workers came in contact with coal-tar sludge. The purpose of the study was to determine if skin contact with coal-tar sludge was an important route of exposure to pyrene because workers were observed to have substantial contact with the sludge. Environmental monitoring revealed minimal airborne exposure to pyrene, a byproduct of the coke distillation process; only one personal breathing zone sample detected pyrene, and at a level of 0.001 mg/m3. However, the mean preshift urinary 1-hydroxypyrene concentration was 1.00 µmol/mol creatinine (range, 0.16 to 2.96 µmol/mol creatinine) and the mean postshift level was 1.7 µmol/mol creatinine (range, 0.24 to 4.85 µmol/mol creatinine) (P < 0.01). These levels probably reflect absorption as a result of skin exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379500; Malkin, Robert 1; Kiefer, Max 1; Tolos, William 1; Source Information: Nov1996, p1141; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2893
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rouse, David A.
AU - DeVito, Joseph A.
AU - Zhongming Li
AU - Byer, Heather
AU - Morris, Sheldon L.
T1 - Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis-, effects on catalase- peroxidase activities and isoniazid resistance.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1996/11//
VL - 22
IS - 3
M3 - Article
SP - 583
EP - 592
PB - Wiley-Blackwell
SN - 0950382X
AB - Recent studies examining the molecular mechanisms of isoniazid (INH) resistance in Mycobacterium tuberculosis have demonstrated that a significant percentage of drug-resistant strains are mutated in the katG gene which encodes a catalase--peroxidase, and the majority of these alterations are missense mutations which result in the substitution of a single amino acid. In previous reports, residues which may be critical for enzymatic activity and the drug-resistant phenotype have been identified by evaluating INH-resistant clinical isolates and in vitro mutants. In this study, site-directed mutagenesis techniques were utilized to alter the wild-type katG gene from M. tuberculosis at 13 of these codons. The effects of these mutations were determined using complementation assays in katG -defective, INH-resistant strains of Mycobacterium smegmatis and Mycobacterium bovis BCG. This mutational analysis revealed that point mutations in the katG gene at nine of the 13 codons can cause drug resistance, and that enzymatic activity and resistance to INH are inversely related. In addition, mutations in the mycobacterial catalase--peroxidase which reduce catalase activity also decrease peroxidase activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbial mutation
KW - Drug resistance in microorganisms
KW - Isoniazid
KW - Mycobacterium tuberculosis
KW - Mutagenesis
KW - Mycobacterium
N1 - Accession Number: 21302212; Rouse, David A. 1; Email Address: DavidR3648@aol.com; DeVito, Joseph A. 1; Zhongming Li 1; Byer, Heather 1; Morris, Sheldon L. 1; Affiliations: 1: Laboratory of Mycobacteria, Center for Biologics Evaluation and Research. US Food and Drug Administration. Building 29, Room 406 (HFM-431), 8800 Rockville Pike, Bethesda, Maryland 20892, USA; Issue Info: Nov1996, Vol. 22 Issue 3, p583; Thesaurus Term: Microbial mutation; Subject Term: Drug resistance in microorganisms; Subject Term: Isoniazid; Subject Term: Mycobacterium tuberculosis; Subject Term: Mutagenesis; Subject Term: Mycobacterium; Number of Pages: 10p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107288529
T1 - Drowning in Alaskan waters.
AU - Lincoln JM
AU - Perkins R
AU - Melton F
AU - Conway GA
Y1 - 1996/11//Nov/Dec96
N1 - Accession Number: 107288529. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Drowning -- Epidemiology -- Alaska
KW - Drowning -- Prevention and Control
KW - Drowning -- Ethnology
KW - Epidemiological Research
KW - Record Review
KW - Vital Statistics
KW - Incidence
KW - Descriptive Statistics
KW - Alaska
KW - Native Americans
KW - Risk Factors
KW - Sex Factors
KW - Age Factors
KW - Occupational Hazards
KW - Alcoholic Intoxication
KW - Rural Health
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 531
EP - 535
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 111
IS - 6
PB - Sage Publications Inc.
AB - Objective. To enumerate drowning fatalities in Alaska in order to identify risk factors and areas for intervention. Methods. Information from death certificates, state troopers' reports, and medical examiner reports were abstracted and analyzed. Rates were calculated using 1990 census figures as denominator data. Results. There were 542 drowning fatalities in Alaska for the years 1988 to 1992. The 20-29 age group had the highest frequency and rate of drownings. The incidence rate for the state was 20 drownings per 100,000 population per year, almost 10 times higher than the overall U.S. rate of 2.11 per 100,000 per year. Incidence rates were highest among adolescent males (10-19), young adult males (20-29), Alaska Natives, and rural residents. Alaska Native males, ages 30-39 averaged 159 drownings per 100,000 per year, the highest drowning rates in the state. Conclusions. Drowning is a major public health concern in Alaska. People who fish commercially and young Native males are groups at high risk for drowning. Intervention efforts should be concentrated on these two populations.
SN - 0033-3549
AD - Alaska Field Station, Division of Safety Research, National Institute for Occupational Safety and Health
U2 - PMID: 8955701.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288529&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107338659
T1 - Codex alimentarius... First International Conference on East-West Perspectives on Functional Foods. Singapore, September 26-29, 1995.
AU - Pothisiri P
AU - Kongchuntuk H
Y1 - 1996/11/02/Nov96 Part 2
N1 - Accession Number: 107338659. Language: English. Entry Date: 19971001. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Food -- Standards
SP - S149
EP - 51
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 54
IS - 11
PB - Oxford University Press / USA
SN - 0029-6643
AD - Secretary-General of the Food and Drug Administration, Ministry of Public Health, Nonthaburi 11000, Thailand
U2 - PMID: 9110593.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107338659&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107338666
T1 - Regulatory aspects of functional foods in Nigeria... First International Conference on East-West Perspectives on Functional Foods. Singapore, September 26-29, 1995.
AU - Osuide GE
Y1 - 1996/11/02/Nov96 Part 2
N1 - Accession Number: 107338666. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Food -- Legislation and Jurisprudence -- Nigeria
KW - Nigeria
SP - S167
EP - S167
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 54
IS - 11
PB - Oxford University Press / USA
SN - 0029-6643
AD - National Agency for Food and Drug Administration and Control (NAFDAC) of Nigeria
U2 - PMID: 9110597.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107338666&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107338670
T1 - The prospect for functional foods in Thailand... First International Conference on East-West Perspectives on Functional Foods. Singapore, September 26-29, 1995.
AU - Pothisiri P
AU - Kongchuntuk H
Y1 - 1996/11/02/Nov96 Part 2
N1 - Accession Number: 107338670. Language: English. Entry Date: 19971001. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Food
KW - Health Promotion
KW - Consumer Product Safety
KW - Thailand
SP - S172
EP - 3
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 54
IS - 11
PB - Oxford University Press / USA
SN - 0029-6643
AD - Food and Drug Administration, Ministry of Public Health, Nonthanuri 11000, Thailand
U2 - PMID: 9110600.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107338670&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Goldman, S. A.;
T1 - Drug-induced psychiatric disease
CT - Drug-induced psychiatric disease
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1996/12/01/
VL - 31
IS - Dec
SP - PI
EP - 56
AD - MEDWATCH, HF-2, Food and Drug Administration, 5600 Fishers Lane, Room 9-57, Rockville, MD 20857, USA
N1 - Accession Number: 33-13379; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Toxicity
N2 - Psychiatric symptomatology that is secondary to the use of drugs, particularly non-psychiatric agents, is a well-known clinical phenomenon. Delirium, delusions, hallucinations and depression are among the psychiatric manifestations that have been reported in association with non-psychiatric drugs. The recognition of drug-induced psychiatric illness is very important, given the extent and severity of the symptomatology that can develop. Awareness of which drugs are most likely to produce specific psychiatric manifestations is crucial to the diagnosis and management of drug-induced psychiatric disease. Learning objectives: 1. Describe specific drug-induced psychiatric symptomatology. 2. Understand the diagnostic/management process utilized in the case of a patient with possible drug-induced psychiatric illness. 3. List clinically significant psychiatric symptomatology associated with the use of certain non-psychiatric drugs. Self-assessment questions: True or False: 1. Depressed mood by itself is a psychotic symptom. 2. If psychiatric symptomatology believed to be secondary to a drug does not resolve immediately (within 24 hours) after the suspected drug is stopped, the symptomatology could not have been due to the drug. 3. Drugs are one of the most common causes of delirium. Answers: 1. F; 2 F; 3. T.
KW - ASHP meeting abstracts--drug induced mental disorders;
KW - Toxicity--drugs--mental disorders;
KW - Mental disorders--drugs--toxicity;
KW - Delirium--drugs--toxicity;
KW - Delusions--drugs--toxicity;
KW - Hallucinations--drugs--toxicity;
KW - Depression--drugs--toxicity;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=33-13379&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - George, E. Olusegun
AU - Kodell, Ralph L.
T1 - Tests of Independence, Treatment Heterogeneity, and Dose-Related Trend With Exchangeable Binary Data.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1996/12//
VL - 91
IS - 436
M3 - Article
SP - 1602
EP - 1610
SN - 01621459
AB - Existing methods of testing for treatment effects for clustered binary data include the beta-binomial, quasilikelihood, and GEE Procedures. All of these methods revolve around the mean response and the second-order correlation. However, these two parameters alone do not fully determine the effect of treatment. This article develops nonparametric likelihood ratio procedures to test for independence, heterogeneity, and dose-related trend in dose-response studies revolving exchangeable binary data. The hypotheses of independence, heterogeneity, and trend are expressed in terms of joint probabilities of similar responses among cluster mates. Constrained maximum likelihood estimates of these probabilities are computed and used to construct test statistics. Unlike the test statistics for independence and heterogeneity, the asymptotic distribution of the likelihood ratio test for trend as not exactly a chi-square. However, an upper bound of its p value is obtained by using a chi-squared distribution. A set of clustered binary data from the Shell Toxicology Laboratory, on the developmental effect of a chemical agent on banded Dutch rabbits, is used to illustrate the various test procedures. The same dataset is used to compare the proposed trend test with some existing trend tests, such as those based on a beta-binomial model, generalized estimating equations, and survey sampling methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORRELATION (Statistics)
KW - PROBABILITY theory
KW - ESTIMATION theory
KW - SAMPLING (Statistics)
KW - BINARY system (Mathematics)
KW - SAMPLE size (Statistics)
KW - Adjusted Cochran--Armitage test
KW - Beta-binomial models
KW - Developmental toxicity data
KW - Effective sample size
KW - Generalized score test
KW - Likelihood ratio tests
KW - Variance inflation factor
N1 - Accession Number: 9702145899; George, E. Olusegun 1; Kodell, Ralph L. 2; Affiliations: 1: Professor, Department of Mathematical Sciences, University of Memphis, Memphis, TN 38152; 2: Acting Director, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079; Issue Info: Dec96, Vol. 91 Issue 436, p1602; Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: PROBABILITY theory; Thesaurus Term: ESTIMATION theory; Thesaurus Term: SAMPLING (Statistics); Subject Term: BINARY system (Mathematics); Subject Term: SAMPLE size (Statistics); Author-Supplied Keyword: Adjusted Cochran--Armitage test; Author-Supplied Keyword: Beta-binomial models; Author-Supplied Keyword: Developmental toxicity data; Author-Supplied Keyword: Effective sample size; Author-Supplied Keyword: Generalized score test; Author-Supplied Keyword: Likelihood ratio tests; Author-Supplied Keyword: Variance inflation factor; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 7098
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107097951
T1 - Developing the National Institute for Occupational Safety and Health's cancer control demonstration projects for farm populations.
AU - Connally LB
AU - Schulte PA
AU - Alderfer RJ
AU - Goldenhar LM
AU - Calvert GM
AU - Davis-King KE
AU - Sanderson WT
Y1 - 1996/12/02/Dec1996 Supplement 4
N1 - Accession Number: 107097951. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; editorial. Supplement Title: Dec1996 Supplement 4. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8508122.
KW - Neoplasms -- Prevention and Control
KW - Farmworkers
KW - National Institute for Occupational Safety and Health
KW - Program Development
SP - 258
EP - 264
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 12
IS - S4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Although farmers experience lower overall cancer rates than the U.S. population, they are at increased risk for cancers of certain sites, such as brain, stomach, lymphatic and hematopoietic, lip, prostate, and skin. Little research has been done to determine the extent to which farmers and their families use cancer control services or hozo their utilization behaviors and cancer survival rates compare to those of nonfarmers in the United States. In 1989, recognizing the occupational uniqueness of farm populations and the limited cancer-related information about them, Congress mandated that the National Institute for Occupational Safety and Health (NIOSH) develop a program to promote cancer control among farming populations. Eight institutions were funded through cooperative agreements to collaborate with NIOSH and each other to develop the demonstration research and intervention projects. The projects are aimed at identifying barriers that prevent farmers, farmworkers, and their families from accessing the fill range of cancer control services, and then implementing interventions to mitigate those barriers. This paper illustrates some of the conceptual and methodological issues NIOSH researchers and their collaborators faced while developing the cancer control program.
SN - 0890-765X
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy., Mailstop R42, Cincinnati, OH 45226
U2 - PMID: 10162856.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107097951&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107097983
T1 - Ensuring the dissemination of cancer control demonstration projects for farmers.
AU - Marconi KM
Y1 - 1996/12/02/Dec1996 Supplement 4
N1 - Accession Number: 107097983. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Dec1996 Supplement 4. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8508122.
KW - Neoplasms -- Prevention and Control
KW - Farmworkers
KW - National Institute for Occupational Safety and Health
KW - Research
SP - 349
EP - 353
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 12
IS - S4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The successful dissemination of the Cancer Control Demonstration Projects for Farmers depends not only on the effectiveness of the grants funded under this program but also on factors external to the grants. In this article, three health-related external factors are examined: the cancers amenable to prevention and control, intervention methodologies, and the organization of rural health care. Changes between 1989 and 1996 in each of these factors and the effects of these changes on the dissemination of grantee findings to public health and medical practitioners are described. Suggestions are offered on actions that the National Institutes for Occupational Safety and Health can undertake to increase the likelihood of adoption of grantee findings.
SN - 0890-765X
AD - Office of Science and Epidemiology, Bureau of Health Resources Development, Health Resources and Services Administration, 7A-07 Parklawn Bldg., 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 10162866.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107097983&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gfroerer, Joseph C.
AU - Greenblatt, Janet C.
AU - Wright, Douglas A.
T1 - Substance Use in the US College-Age Population: Differences According to Educational Status and Living Arrangement.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/01//
VL - 87
IS - 1
M3 - Article
SP - 62
EP - 65
PB - American Public Health Association
SN - 00900036
AB - Objectives. Substance use in the college-age population is an important public health and educational concern. This study compared rates of use among college students and non students, including high school dropouts. from a single data source representative of the nation. Methods. Rates of use were estimated from the combined National Household Surveys on Drug Abuse from 1991 to 1993. Logistic regression models were used to test the effects of educational status and living arrangement. Results. Educational status and living arrangement were found to be. significant predictors of substance use. Rates of illicit drug and cigarette use were highest among high school dropouts, while current and heavy alcohol use were highest among college students. who did not live with their parents. Conclusions. Substantial variation in substance use patterns Within the college-age population suggests that overall rates of use for young adults should not be used to characterize specific subgroups of young adults. These data from a single source will thus help planners more clearly distinguish the service needs of the diverse subgroups within this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Substance abuse
KW - College students -- Attitudes
KW - School dropouts
KW - Drinking of alcoholic beverages
KW - Young adults -- Alcohol use -- United States
KW - Drug overdose
KW - Regression analysis
KW - United States
N1 - Accession Number: 9702240098; Gfroerer, Joseph C. 1; Greenblatt, Janet C. 1; Wright, Douglas A. 1; Affiliations: 1: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md.; Issue Info: Jan1997, Vol. 87 Issue 1, p62; Subject Term: Substance abuse; Subject Term: College students -- Attitudes; Subject Term: School dropouts; Subject Term: Drinking of alcoholic beverages; Subject Term: Young adults -- Alcohol use -- United States; Subject Term: Drug overdose; Subject Term: Regression analysis; Subject: United States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3417
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107354161
T1 - Substance use in the US college-age population: differences according to educational status and living arrangement.
AU - Gfroerer JC
AU - Greenblatt JC
AU - Wright DA
Y1 - 1997/01//
N1 - Accession Number: 107354161. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Educational Status
KW - Substance Abuse
KW - Students, College
KW - Student Dropouts
KW - Residence Characteristics
KW - United States
KW - Comparative Studies
KW - Multiple Logistic Regression
KW - Surveys
KW - Interviews
KW - Multi-Stage Cluster
KW - Questionnaires
KW - Data Analysis Software
KW - Odds Ratio
KW - Confidence Intervals
KW - Adolescence
KW - Adult
KW - Human
SP - 62
EP - 65
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 87
IS - 1
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: Substance use in the college-age population is an important public health and educational concern. This study compared rates of use among college students and nonstudents, including high school dropouts, from a single data source representative of the nation. METHODS: Rates of use were estimated from the combined National Household Surveys on Drug Abuse from 1991 to 1993. Logistic regression models were used to test the effects of educational status and living arrangement. RESULTS: Educational status and living arrangement were found to be significant predictors of substance use. Rates of illicit drug and cigarette use were highest among high school dropouts, while current and heavy alcohol use were highest among college students who did not live with their parents. CONCLUSIONS: Substantial variation in substance use patterns within the college-age population suggests that overall rates of use for young adults should not be used to characterize specific subgroups of young adults. These data from a single source will thus help planners more clearly distinguish the service needs of the diverse subgroups within this population.
SN - 0090-0036
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16C-06, Rockville, MD 20857
U2 - PMID: 9065228.
DO - 10.2105/AJPH.87.1.62
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107354161&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2011-24938-047
AN - 2011-24938-047
AU - Murphy, Lawrence R.
ED - Rogers, Wendy A.
ED - Rogers, Wendy A., (Ed)
T1 - Psychological distress in relation to employee age and job tenure.
T2 - Designing for an aging population: Ten years of human factors/ergonomics research.
Y1 - 1997///
SP - 213
EP - 215
CY - Santa Monica, CA, US
PB - Human Factors and Ergonomics Society
SN - 0-945289-08-1
SN - 978-0-945289-08-1
AD - Murphy, Lawrence R., Applied Psychology and Ergonomics Branch, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, US, 45226
N1 - Accession Number: 2011-24938-047. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; Applied Psychology and Ergonomics Branch, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, US. Release Date: 20121008. Correction Date: 20160616. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-945289-08-1, Paperback; 978-0-945289-08-1, Paperback. Language: English. Major Descriptor: Age Differences; Career Development; Occupational Stress; Occupational Tenure; Socialization. Minor Descriptor: Distress; Organizational Climate. Classification: Gerontology (2860); Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Interview. References Available: Y. Page Count: 3.
AB - The present study examined psychological distress among workers at various stages of career development, with special reference to the first year of job tenure, the organizational socialization period. Measures of psychological and physical health, as well as demographic data, were obtained from 3,151 employed persons who participated in a national health interview survey conducted by the Census Bureau in 1978. Analysis of covariance was performed in which employee age and job tenure were predictor variables, and gender, marital status, educational level, and number of physical health conditions entered as covariates. The results indicated that distress was highest among workers with less than 6 months tenure, and distress levels decreased progressively with longer tenure. Employee age moderated these effects, however, in that older workers with less than 6 months tenure reported higher levels of distress than younger workers with similar tenure. Older workers also showed a delayed decrease in psychological distress with longer tenure than younger workers. The results identify organizational socialization as a critical period with respect to employee mental health. Little empirical research has examined the relationship between job stress and stage of career development. The substantial amount research devoted to job stress and career development have developed largely as independent endeavors. For example, job stress studies typically treat age and tenure (i.e. career stage) as nuisance variables whose influence on health outcome variables is controlled statistically. Likewise, career development studies typically do not include a health outcome variable, preferring instead to focus on performance, withdrawal behaviors, job satisfaction. Consequently, there has been little cross-fertilization of ideas and theories in these areas. The few studies which examined job stress across career stage have reported provocative findings. There is evidence that work conditions which are perceived as stressful, and the strategies used to cope with stress, differ among older and younger workers. Also, levels of psychological distress appear to differ by age; older workers generally report lower distress than younger workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychological distress
KW - career development
KW - job tenure
KW - organizational socialization
KW - employee mental health
KW - job stress
KW - age differences
KW - 1997
KW - Age Differences
KW - Career Development
KW - Occupational Stress
KW - Occupational Tenure
KW - Socialization
KW - Distress
KW - Organizational Climate
KW - 1997
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-24938-047&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1997-08820-025
AN - 1997-08820-025
AU - Blumenthal, Susan J.
AU - Wood, Susan I.
ED - Gallant, Sheryle J.
ED - Keita, Gwendolyn Puryear
ED - Royak-Schaler, Reneé
ED - Gallant, Sheryle J., (Ed)
ED - Keita, Gwendolyn Puryear, (Ed)
ED - Royak-Schaler, Reneé, (Ed)
T1 - Women's health care: Federal initiatives, policies, and directions.
T2 - Health care for women: Psychological, social, and behavioral influences.
Y1 - 1997///
SP - 2
EP - 10
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-422-0
N1 - Accession Number: 1997-08820-025. Partial author list: First Author & Affiliation: Blumenthal, Susan J.; US Public Health Service, Office on Women's Health, Washington, DC, US. Release Date: 19970101. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-422-0, Paperback. Language: English. Major Descriptor: Health; Health Care Services; Human Females; Legislative Processes; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 9.
AB - In this chapter, the authors provide a brief historical perspective on the focus on women's health in the United States. They begin with the early struggle to give women control over their reproduction and then discuss the legislation passed to include women in clinical research studies, the Women's Health Equity Act of 1990, and the more recent legislative proposals and programs on breast and cervical cancer, contraception and infertility, and violence against women. They also discuss some of the mechanisms put into place to ensure continued attention to women's health in the future. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women's health care
KW - women's health
KW - federal initiatives
KW - federal policies
KW - legislation
KW - future directions
KW - 1997
KW - Health
KW - Health Care Services
KW - Human Females
KW - Legislative Processes
KW - Health Care Policy
KW - 1997
DO - 10.1037/10235-025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-08820-025&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 1997-08429-018
AN - 1997-08429-018
AU - Carey, Mary Ann
ED - Winiarski, Mark G.
ED - Winiarski, Mark G., (Ed)
T1 - Qualitative approaches to evaluation.
T2 - HIV mental health for the 21st century.
Y1 - 1997///
SP - 291
EP - 304
CY - New York, NY, US
PB - New York University Press
SN - 0-8147-9312-6
SN - 0-8147-9311-8
N1 - Accession Number: 1997-08429-018. Partial author list: First Author & Affiliation: Carey, Mary Ann; US Public Health Service, Substance Abuse and Mental Health Services Administration, Ctr for Mental Health Services, Rockville, MD, US. Release Date: 19970101. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8147-9312-6, Hardcover; 0-8147-9311-8, Paperback. Language: English. Major Descriptor: HIV; Mental Health Program Evaluation. Classification: Health & Mental Health Services (3370). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 14.
AB - This chapter provides basic information regarding methods and issues related to conducting qualitative program evaluations, with an emphasis on HIV-related issues. The differences between qualitative and quantitative program evaluations are discussed, with emphasis upon the advantages the qualitative methods. The advantages of qualitative methods noted include their utility in exploring new topics, replicating work with new populations, and developing hypotheses. The strengths of combining both approaches are also discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - qualitative evaluation of HIV related mental health programs
KW - 1997
KW - HIV
KW - Mental Health Program Evaluation
KW - 1997
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-08429-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107317146
T1 - Infusion pump adverse events: experience from medical device reports.
AU - Brown SL
AU - Morrison AE
AU - Parmentier CM
AU - Woo EK
AU - Vishnuvajjala RL
Y1 - 1997/01//1997 Jan-Feb
N1 - Accession Number: 107317146. Language: English. Entry Date: 19970401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8804311.
KW - Infusion Pumps -- Adverse Effects
KW - Mandatory Reporting
KW - United States Food and Drug Administration
KW - Equipment Failure
KW - Infusion Pumps, Implantable -- Adverse Effects
KW - Human
SP - 41
EP - 49
JO - Journal of Intravenous Nursing
JF - Journal of Intravenous Nursing
JA - J INTRAVENOUS NURS
VL - 20
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Infusion pumps are used in the hospital setting, nursing home, and increasingly, in the home. Medical Device Reports to the Food and Drug Administration of adverse events during the use of infusion pumps for a 10-year period are described. Examples of cases reported to the Food and Drug Administration are provided. The problems reported by medical facilities (hospitals, medical centers, hospital pharmacies, or nursing homes) are compared with those that occur in the home or reported by home health care agencies. Overall, there were no differences in the types of adverse events reported by medical facilities when compared with reports from home health care agencies. However, there were differences in the location of use of some of the infusion pumps studied, which could reflect the trend toward home care over the past decade.
SN - 0896-5846
AD - Epidemiology Branch, Center for Devices and Radiological Health, Rockville, Maryland
U2 - PMID: 9060364.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107317146&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288547
T1 - The complicated task of monitoring vaccine safety... including commentary by Freeman P.
AU - Ellenberg SS
AU - Chen RT
Y1 - 1997/01//Jan/Feb97
N1 - Accession Number: 107288547. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; commentary; pictorial. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Vaccines -- Adverse Effects
KW - Drug Approval
KW - Voluntary Reporting -- Methods
KW - Vaccines -- Standards
KW - Drug Monitoring -- Methods
KW - Pertussis Vaccine -- Adverse Effects
KW - Vaccines -- Legislation and Jurisprudence -- United States
KW - United States
KW - Government Programs
KW - Sudden Infant Death -- Etiology
KW - United States Food and Drug Administration -- Standards
SP - 10
EP - 21
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 112
IS - 1
PB - Sage Publications Inc.
AB - VACCINATION IS AN ESSENTIAL component of modern public health programs and is among our most cost-effective medical interventions. Yet despite vaccines' clear effectiveness in reducing risks of diseases that previously attacked large proportions of the population, caused many deaths, and left many people with permanent disabilities, current vaccination policies are not without controversy. Vaccines, like all other pharmaceutical products, are not entirely risk-free; while most known side effects are minor and self-limited, some vaccines have been associated with very rare but serious adverse effects. Because such rare effects are often not evident until vaccines come into widespread use, the Federal government maintains ongoing surveillance programs to monitor vaccine safety. The interpretation of data from such programs is complex and is associated with substantial uncertainty. A continual effort to monitor these data effectively and to develop more precise ways of assessing risks of vaccines is necessary to ensure public confidence in immunization programs.
SN - 0033-3549
AD - Director, Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA
U2 - PMID: 9018282.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288547&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288553
T1 - Cost of hospitalizations associated with sickle cell disease in the United States.
AU - Davis H
AU - Moore RM Jr.
AU - Gergen PJ
Y1 - 1997/01//Jan/Feb97
N1 - Accession Number: 107288553. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Anemia, Sickle Cell -- Economics
KW - Health Facility Costs
KW - Anemia, Sickle Cell -- Epidemiology
KW - Health Services Research
KW - Record Review
KW - Epidemiological Research
KW - Insurance, Health, Reimbursement
KW - Descriptive Statistics
KW - Hospitalization
KW - Economic Aspects of Illness
KW - Length of Stay
KW - Cost Savings
KW - Research Support
KW - Infant, Newborn
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Human
SP - 40
EP - 43
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 112
IS - 1
PB - Sage Publications Inc.
AB - Objective. This study estimated the number and cost of hospitalizations associated with sickle cell disease in the United States. Methods. To estimate the number of hospitalizations per year in the United States of people with sickle cell disease, the authors used data for the years 1989 through 1993 from national hospital discharge surveys conducted by the National Center for Health Statistics. The author's derived cost estimates using data from a 1992 national hospital discharge survey conducted by the Agency for Health Care Policy and Research and a 1992 survey of physicians conducted by the American Medical Association. Results. During the years 1989 through 1993, there were on aver-age an estimated 75,000 hospitalizations per year of children and adults with sickle cell disease. The average direct cost per hospitalization (in 1996 dollars) was estimated at $6300, for a total direct cost of $475 million per year. In 66% of hospital discharge records, government programs were listed as the expected principal source of payment. Conclusions. The cost of hospitalizations associated with sickle cell disease is substantial. Because government programs pay most of this cost, further government-funded research to develop interventions that prevent complications of the disease has great potential for cost savings as well as for reducing the suffering of those afflicted with this painful genetic disorder. These national cost estimates contribute to an understanding of the impact of sickle cell disease and should be useful in establishing research priorities.
SN - 0033-3549
AD - Office of Epidemiology and Biostatics, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Room 15-B-18, HFD-733, Rockville MD 20857; e-mail: davisha@cder.fda.gov
U2 - PMID: 9018287.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288553&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288564
T1 - Geographic differences in mortality of young children with sickle cell disease in the United States.
AU - Davis H
AU - Gergen PJ
AU - Moore RM Jr.
Y1 - 1997/01//Jan/Feb97
N1 - Accession Number: 107288564. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Anemia, Sickle Cell -- Mortality -- In Infancy and Childhood
KW - Geographic Factors
KW - Health Services Accessibility
KW - Epidemiological Research
KW - Record Review
KW - Vital Statistics
KW - Child Mortality
KW - Prevalence
KW - Relative Risk
KW - Fisher's Exact Test
KW - P-Value
KW - Odds Ratio
KW - Probability
KW - Risk Factors
KW - Blacks
KW - Quality of Health Care
KW - United States
KW - Florida
KW - Pennsylvania
KW - Maryland
KW - Infant
KW - Child, Preschool
KW - Male
KW - Female
KW - Human
SP - 52
EP - 58
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 112
IS - 1
PB - Sage Publications Inc.
AB - Objectives. Because geographic differences in health care have been found for many diseases, including those affecting children, there are probably geographic differences in the health care of young children with sickle cell disease. Consequently, survival of young children with sickle cell disease might differ among geographic areas. This study's objective was to identify areas in the United States where young children with sickle cell disease are at especially high and low risk of dying. Methods. Using U.S. death certificate data from 1968 through 1992, the authors calculated the mortality rates of 1- through 4-year-old black children with sickle cell disease for states, counties, and cities. Deaths from trauma, congenital anomalies, and perinatal conditions were excluded. Results. From 1968 through 1980 and from 1981 through 1992, 1- through 4-year-old black children with sickle cell disease in Florida had a markedly higher risk of dying, and those in Pennsylvania had a markedly lower risk of dying, than the average 1- through 4-year-old black child with the disease in the United States. From 1981 through 1992, 1- through 4-year-old black children with sickle cell disease in Maryland had the lowest mortality rate in the nation. During the same time period, 1- through 4-year-old black children with sickle cell disease in five counties in Florida were at especially high risk, while in Baltimore no young black children with the disease died. These geographic differences in mortality of black children with sickle cell disease greatly exceeded geographic differences in mortality of black children without the disease. Conclusions. Marked differences exist across the United States in mortality of young black children with sickle cell disease. To improve survival for children with the disease in high mortality areas, evaluations should be made of the accessibility and quality of medical care, and of parents' health care seeking behavior and compliance with antibiotic prophylaxis. In addition, efforts should be made to understand and duplicate the success of treatment programs in low mortality areas.
SN - 0033-3549
AD - Office of Epidemiology and Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Room 15-B-18, HFD-733, Rockville, MD 20857; e-mail: davisha@cder.fda.gov
U2 - PMID: 9018289.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288564&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107253665
T1 - Privatizing public mental health and substance abuse services: issues, opportunities, and challenges.
AU - Chalk M
Y1 - 1997///1997 Winter
N1 - Accession Number: 107253665. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Health Services Administration; Nursing; Peer Reviewed; USA. NLM UID: 9306156.
KW - Private Sector
KW - Mental Health Services
KW - Substance Abuse -- Therapy
KW - Managed Care Programs
KW - Economic Aspects of Illness
KW - Quality Improvement
KW - Organizational Objectives
KW - Accountability
KW - Consumer Participation
SP - 55
EP - 64
JO - Quality Management in Health Care
JF - Quality Management in Health Care
JA - QUAL MANAGE HEALTH CARE
VL - 5
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1063-8628
AD - Director, Office of Managed Care, Center for Substance Abuse and Treatment, Substance Abuse and Mental Health Service Administration, US Department of Health and Human Services in Rockville, MD
U2 - PMID: 10166213.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107253665&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2007-10510-001
AN - 2007-10510-001
AU - Dixon, Lisa
T1 - On co-occurring addictive and mental disorders.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 1997/01//
VL - 67
IS - 1
SP - 158
EP - 158
CY - US
PB - American Orthopsychiatric Association, Inc.
SN - 0002-9432
SN - 1939-0025
N1 - Accession Number: 2007-10510-001. PMID: 9034032 Partial author list: First Author & Affiliation: Dixon, Lisa; Center for Mental Health Services Research, University of Maryland School of Medicine, Baltimore, MD, US. Other Publishers: Educational Publishing Foundation; Wiley-Blackwell Publishing Ltd. Release Date: 20070716. Correction Date: 20160908. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Addiction; Comorbidity; Mental Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Page Count: 1. Issue Publication Date: Jan, 1997. Copyright Statement: American Orthopsychiatric Association, Inc. 1997.
AB - Notes that the special section on co-occurring addictive and mental disorders (COAMD) is an outstanding addition to the literature on this topic. Subjects covered include a history of the fragmented management of mental health and substance abuse research and services at both federal and state levels, a first-person account of a struggle to recover from co-occurring mental and addictive disorders, and analyses of time of onset of disorders. As research on the burdens and benefits of family caregiving moves forward, as research on the effectiveness of family psychosocial interventions becomes more compelling, and further, as we begin to understand more of the genetic, environmental, and social risk factors for substance abuse and mental disorders, it is essential that we do not ignore consideration of the family in future research on persons with co-occurring addictive and mental disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - comorbidity
KW - addiction
KW - mental disorders
KW - 1997
KW - Addiction
KW - Comorbidity
KW - Mental Disorders
KW - 1997
DO - 10.1037/h0085076
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10510-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1998-00027-001
AN - 1998-00027-001
AU - Simons-Morton, Bruce G.
AU - Cummings, Sharon Snider
T1 - Evaluation of a local designated driver and responsible server program to prevent drinking and driving.
JF - Journal of Drug Education
JO - Journal of Drug Education
JA - J Drug Educ
Y1 - 1997///
VL - 27
IS - 4
SP - 321
EP - 333
CY - US
PB - Baywood Publishing
SN - 0047-2379
SN - 1541-4159
N1 - Accession Number: 1998-00027-001. Partial author list: First Author & Affiliation: Simons-Morton, Bruce G.; National Insts of Health, Public Health Service, Bethesda, MD, US. Other Publishers: Sage Publications. Release Date: 19980401. Correction Date: 20150126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Driving Under the Influence; Prevention; Program Evaluation. Minor Descriptor: Drivers; Service Personnel. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 13. Issue Publication Date: 1997.
AB - To evaluate the impact of a designated driver and responsible server program in Houston, the authors assessed server training courses, observed and interviewed 55 servers and patrons at 5 establishments participating in the program, and reviewed the distribution of vouchers awarded for a safe ride home by taxi. The training course for alcoholic beverage servers produced significant improvements in the participants' perceptions about their role in preventing drunk driving. In 5 participating establishments 15.6% of servers wore buttons announcing the establishment's participation in the program; immediately after retraining 26.6% wore the buttons. Of the eligible patrons in these establishments 6.6% actually participated in the designated driver program. The program provided an average of 0.7 safe ride home vouchers per establishment per month. In 1 additional establishment an experiment was conducted in which servers always announced the designated driver program to patrons, but no increase in the prevalence of designated drivers occurred. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evaluation of designated driver & responsible server program
KW - drinking & driving
KW - bar patrons & personnel
KW - 1997
KW - Driving Under the Influence
KW - Prevention
KW - Program Evaluation
KW - Drivers
KW - Service Personnel
KW - 1997
DO - 10.2190/2RJA-22Y1-R15T-ULM8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1998-00027-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Schulte, P. A.
T1 - Molecular Epidemiology of Occupational and Environmental Lung Disease.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 1997/01/02/1997 Inhaled Particles VIII
VL - 41
M3 - Article
SP - 1
EP - 6
SN - 00034878
AB - The article presents a study that investigates the molecular epidemiology of the environmental and occupational lung diseases in the U.S. It features the biomarkers used by researchers to determine susceptibility and the correlation of exposure to occupational hazards and lung diseases. Moreover, the benefits of using biological molecular biomarkers are also mentioned.
KW - RESEARCH
KW - Molecular epidemiology
KW - Biochemical markers
KW - Occupational hazards
KW - Lung diseases
KW - Public health -- United States
N1 - Accession Number: 90325926; Schulte, P. A. 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati, OH 45226, U.S.A.; Issue Info: 1997 Inhaled Particles VIII, Vol. 41, p1; Thesaurus Term: RESEARCH; Thesaurus Term: Molecular epidemiology; Thesaurus Term: Biochemical markers; Thesaurus Term: Occupational hazards; Subject Term: Lung diseases; Subject Term: Public health -- United States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kuempel, E. D.
AU - O'Flaherty, E. J.
AU - Stayner, L. T.
AU - Attfield, M. D.
AU - Green, F. H. Y.
AU - Vallyathan, V.
T1 - Relationships Between Lung Dust Burden, Pathology and Lifetime Exposure in an Autopsy Study of U.S. Coal Miners.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 1997/01/02/1997 Inhaled Particles VIII
VL - 41
M3 - Article
SP - 384
EP - 389
SN - 00034878
AB - The article discusses the association of lung dust burden, pathology and lifetime exposure in an autopsy study of coal miners in the U.S. The correlations between radiographical and pathological evidence of coal workers' pneumoconiosis and lung dust burden have been described in previous studies. The estimates of miners' lifetime cumulative exposures to respirable coal mine dust have been included in the present study.
KW - Mine dusts
KW - Coal mines & mining
KW - Lungs -- Dust diseases
KW - Coal miners
KW - United States
N1 - Accession Number: 90325979; Kuempel, E. D. 1,2; O'Flaherty, E. J. 2; Stayner, L. T. 1; Attfield, M. D. 3; Green, F. H. Y. 4; Vallyathan, V. 3; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Education and Information Division 4676 Columbia Parkway, MS C32, Cincinnati, OH 45226; 2: University of Cincinnati, Department of Environmental Health Cincinnati, OH; 3: NIOSH, Division of Respiratory Disease Studies , Morgantown, West Virginia, U.S.A.; 4: University of Calgary, Department of Pathology, Calgary Alberta, Canada; Issue Info: 1997 Inhaled Particles VIII, Vol. 41, p384; Thesaurus Term: Mine dusts; Thesaurus Term: Coal mines & mining; Subject Term: Lungs -- Dust diseases; Subject Term: Coal miners; Subject: United States; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Liu, X.
AU - Keane, M. J.
AU - Ong, T.
AU - Antonini, J. M.
AU - Wallace, W. E.
T1 - Respirable Quartz Loss of an Adsorbed Pulmonary Surfactant In Vitro and Expression of Cytotoxicity or Genotoxicity.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 1997/01/02/1997 Inhaled Particles VIII
VL - 41
M3 - Article
SP - 415
EP - 419
SN - 00034878
AB - The article presents a study on the respirable quartz loss of an adsorbed pulmonary surfactant in vitro and expression of cytotoxicity or genotoxicity. It notes the use of surfactant dipalmitoyl phosphatidylcholine (DPPC) in aqueous dispersion which absorbs onto the surface of respirable sized quartz particles and suppresses membranolytic activity. It examines the in vitro toxicity of pulmonary macrophage by DPPC-coated quartz dust. It also looks on use of fluorescence-label substituted DPPC.
KW - Surface active agents
KW - Genetic toxicology
KW - Pulmonary surfactant
KW - Quartz
KW - Dipalmitoyl lecithin
KW - Aqueous solutions
KW - Macrophages
N1 - Accession Number: 90325986; Liu, X. 1; Keane, M. J. 1; Ong, T. 1; Antonini, J. M. 2; Wallace, W. E. 1; Affiliations: 1: National Institute for Occupational Safety and Health 1196 Willowdale Road, Morgantown, WV 26505, U.S.A.; 2: Harvard School of Public Health Boston, MA, U.S.A.; Issue Info: 1997 Inhaled Particles VIII, Vol. 41, p415; Thesaurus Term: Surface active agents; Thesaurus Term: Genetic toxicology; Subject Term: Pulmonary surfactant; Subject Term: Quartz; Subject Term: Dipalmitoyl lecithin; Subject Term: Aqueous solutions; Subject Term: Macrophages; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107251150
T1 - The evolving health care system: the role of the health resources and services administration... proceedings of selected lectures delivered on November 2, 1996 at the Association of Schools of Allied Health Professions Summit on the Evolving Health Care Systems on Allied Health Education in Charleston, South Carolina.
AU - Sumaya CV
Y1 - 1997///1997 Winter
N1 - Accession Number: 107251150. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0361603.
KW - Government Agencies -- United States
KW - Role
KW - Health Care Delivery -- Trends -- United States
KW - Allied Health Professions
KW - United States Department of Health and Human Services
KW - Medically Underserved
KW - Allied Health Professions -- Manpower -- United States
KW - United States
SP - 17
EP - 19
JO - Journal of Allied Health
JF - Journal of Allied Health
JA - J ALLIED HEALTH
VL - 26
IS - 1
CY - Washington, District of Columbia
PB - American Society of Allied Health Professionals
SN - 0090-7421
AD - Health Resources and Services Administration
U2 - PMID: 9136057.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107251150&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107265598
T1 - The legal and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco.
AU - Kessler DA
AU - Barnett PS
AU - Witt A
AU - Zeller MR
AU - Mande JR
AU - Schultz WB
AU - Kessler, D A
AU - Barnett, P S
AU - Witt, A
AU - Zeller, M R
AU - Mande, J R
AU - Schultz, W B
Y1 - 1997/02/05/
N1 - Accession Number: 107265598. Language: English. Entry Date: 19980601. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Nicotine -- Pharmacodynamics
KW - Tobacco
KW - Industry -- Legislation and Jurisprudence
KW - Legislation, Drug
KW - Smoking
KW - United States Food and Drug Administration
KW - United States
KW - Health Policy
KW - Tobacco, Smokeless
KW - Substance Use Disorders -- Prevention and Control
SP - 405
EP - 409
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 277
IS - 5
CY - Chicago, Illinois
PB - American Medical Association
AB - On August 28, 1996, the US Food and Drug Administration (FDA) asserted jurisdiction over cigarettes and smokeless tobacco under the Federal Food, Drug, and Cosmetic Act. Under this Act, a product is a "drug" or "device" subject to FDA jurisdiction if it is "intended to affect the structure or any function of the body." The FDA determined that nicotine in cigarettes and smokeless tobacco does "affect the structure or any function of the body" because nicotine causes addiction and other pharmacological effects. The FDA then determined that these pharmacological effects are "intended" because (1) a scientific consensus has emerged that nicotine is addictive; (2) recent studies have shown that most consumers use cigarettes and smokeless tobacco for pharmacological purposes, including satisfying their addiction to nicotine; and (3) newly disclosed evidence from the tobacco manufacturers has revealed that the manufacturers know that nicotine causes pharmacological effects, including addiction, and design their products to provide pharmacologically active doses of nicotine. The FDA thus concluded that cigarettes and smokeless tobacco are subject to FDA jurisdiction because they contain a "drug," nicotine, and a "device" for delivering this drug to the body.
SN - 0098-7484
AD - US Food and Drug Administration, US Department of Health and Human Services, Rockville, Md. 20857, USA
AD - US Food and Drug Administration, 5600 Fishers Ln. 14-71 PKLN, Rockville, MD 20857
U2 - PMID: 9010173.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107265598&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107191216
T1 - Measurement of radiofrequency electromagnetic fields in and around ambulances.
AU - Boivin WS
AU - Boyd SM
AU - Coletta JA
AU - Neunaber LM
AU - Boivin, W S
AU - Boyd, S M
AU - Coletta, J A
AU - Neunaber, L M
Y1 - 1997/03//1997 Mar-Apr
N1 - Accession Number: 107191216. Language: English. Entry Date: 19990601. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Electromagnetic Fields
KW - Ambulances
KW - Equipment Reliability
KW - Wireless Communications
KW - Data Analysis, Statistical
KW - Electromagnetic Fields -- Evaluation
KW - Human
SP - 145
EP - 154
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 31
IS - 2
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - Electromagnetic interference (EMI) with medical devices can threaten patient safety. More information is needed regarding circumstances in health care environments in which electromagnetic (EM) field strengths are expected to be high, such as emergency/transport. In ambulances medical devices and communications equipment must function properly in close proximity. This study characterized EM fields in and around ambulances under realistic conditions. Two types of ambulances were surveyed: the advanced life support (ALS) unit and the basic life support (BLS) unit. The surveys were conducted on-site using the ambulance mobile radio as the primary source of EM energy. Broadband field-strength measurements were collected at various locations in and around the ambulance to map interior and exterior EM field distributions. Nine ambulances were surveyed. In addition to the transmitter power and frequency, the field strengths measured were shown to be dependent upon the shielding provided by the ambulance roof and proximity of the measurement probe to the antenna. Field-strength measurements frequently exceeded the 3 V/m standard immunity level for devices set by the IEC Standard 601-1-2. The results indicate that the ambulance environment presents a considerable challenge to medical devices specifically used for emergency medical care. In order to assure their proper operation, medical devices used for transport emergency care must be able to withstand exposure to EM field strengths comparable to those reported in this study.
SN - 0899-8205
AD - U.S. Food and Drug Administration, Winchester Engineering and Analytical Center, MA 01890, USA
U2 - PMID: 9099436.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107191216&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - RODGERS, KATHLEEN
AU - KLYKKEN, PAAL
AU - JACOBS, JOSHUA
AU - FRONDOZA, CARMELITA
AU - TOMAZIC, VESNA
AU - ZELIKOFF, JUDITH
T1 - Immunotoxicity of Medical Devices1.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1997/03//
VL - 36
IS - 1
M3 - Article
SP - 1
EP - 3
PB - Oxford University Press / USA
SN - 02720590
AB - Determination of the ability of a medical device to interact with the immune system currently involves assessment of the immuno-genic potential and biocompatibility of the device or an extract of the device. However, implants are often in the body for extended periods of time and/or are placed by a surgical procedure that in and of itself will generate an acute inflammatory response. This symposium discussed studies that have been performed to evaluate the immunogenicity of various devices consisting of several different compositions (i.e., silicone, metals, and latex) in contact with different anatomical sites, the ability of a device to modulate an inflammatory response generated by a surgical procedure or trauma, and the response of the body to a material left in place for extended periods of time. This symposium brought together scientists from many different disciplines to begin to identify and fill in the gaps in this area. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibody formation
KW - Immunotoxicology
KW - Immune system
KW - Antigen presentation
KW - Inflammation
N1 - Accession Number: 82413044; RODGERS, KATHLEEN 1; KLYKKEN, PAAL 2; JACOBS, JOSHUA 3; FRONDOZA, CARMELITA 4; TOMAZIC, VESNA 5; ZELIKOFF, JUDITH 6; Affiliations: 1: Livingston Research Center, University of Southern California School of Medicine 1321 North Mission Road, Los Angeles, California 90033; 2: † Dow Corning Corporation Midland, Michigan 48686; 3: Department of Orthopedic Surgery, Rush Medical College, Rush Arthritis and Orthopedic Institute Chicago, Illinois 60612; 4: Johns Hopkins Orthopedics, Good Samaritan Hospital 5601 Loch Raven Boulevard G-1, Baltimore, Maryland 21239; 5: Center for Medical Devices, Food and Drug Administration Rockville, Maryland 20857; 6: New York University Medical Center, Nelson Institute of Environmental Medicine Long Meadow Road, Tuxedo, New York 10987; Issue Info: 1997, Vol. 36 Issue 1, p1; Thesaurus Term: Antibody formation; Subject Term: Immunotoxicology; Subject Term: Immune system; Subject Term: Antigen presentation; Subject Term: Inflammation; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107344603
T1 - Considerations in presenting, interpreting, and reviewing research findings.
AU - Niemcrynk SJ
AU - Glascoff DW
Y1 - 1997/03//1997 Mar
N1 - Accession Number: 107344603. Language: English. Entry Date: 19971101. Revision Date: 20150818. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9111439.
KW - Writing for Publication
KW - Education, Continuing (Credit)
SP - 41
EP - 47
JO - Journal of Transplant Coordination
JF - Journal of Transplant Coordination
JA - J TRANSPLANT COORD
VL - 7
IS - 1
CY - Boulder, Colorado
PB - InnerDoorway Health Media
AB - By disseminating reports of well-conducted research in peer-reviewed journals, investigators regularly provide valuable information and insights to other professionals. Prospective authors of such reports should be aware that submitted manuscripts undergo considerable scrutiny and analysis by reviewers and editors as part of the publication cycle and, later, by readers for whom the information is intended. Therefore, when a researcher becomes an author, he or she should attempt to be as complete as possible in meeting the needs of those audiences. In this article, we discuss problems often found in research reports submitted to peer-reviewed journals so that investigators may improve the quality of their manuscripts.
SN - 0905-9199
AD - Health Resources and Services Administration, Bureau of Health Resources Development, Office of Science and Epidemiology, Resources Analysis Branch, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ruijin Yao
AU - Burr, Donald H.
AU - Guerry, Patricia
T1 - CheY-mediated modulation of Campylobacter jejuni virulence.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 1997/03//
VL - 23
IS - 5
M3 - Article
SP - 1021
EP - 1031
PB - Wiley-Blackwell
SN - 0950382X
AB - Four motile, non-adherent and non-Invasive mutants of Campylobacter jejuni 81-176 generated by a site-specific insertional mutagenesis scheme were characterized at the molecular level and all contained a duplication of the same region of the chromosome. When this region was cloned from wild-type 81-176 and transferred into 81-176 on a shuttle plasmid, the same non-invasive phenotype as the original mutants was observed, suggesting that the region contained a repressor of adherence and invasion. The smallest piece of DNA identified which was capable of repressing adherence and invasion was a 0.8 kb fragment encoding the cheY gene of C. jejuni . To confirm further that CheY was responsible for the observed non-adherent and non-invasive phenotypes, the cheY gene was inserted into the aryfsulfatase gene of 81- 176 to generate a strain with two chromosomal copies of CheY . This diploid strain displayed the same nonadherent and non-invasive phenotype as the original mutants. Insertional inactivation of the cheY gene in 81-176 resulted in an approx. threefold increase in adherence and invasion in vitro , but this strain was unable to colonize or cause disease in animals. The diploid cheY strain, although able to colonize mice, was attenuated in a ferret disease model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter jejuni
KW - GENETICS
KW - Mutagenesis
KW - Phenotype
KW - Gene silencing
KW - Plasmids
KW - DNA
N1 - Accession Number: 21318395; Ruijin Yao 1; Burr, Donald H. 1,2; Guerry, Patricia 1; Email Address: guerry_p@mail2.nmri.nnmc.navy.mil; Affiliations: 1: Enteric Diseases Program, Naval Medical Research Institute Annex, 12300 Washington Avenue, Rockville, Bethesda, Maryland 20852, USA; 2: The Food and Drug Administration, Washington, DC, USA; Issue Info: Mar1997, Vol. 23 Issue 5, p1021; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: GENETICS; Subject Term: Mutagenesis; Subject Term: Phenotype; Subject Term: Gene silencing; Subject Term: Plasmids; Subject Term: DNA; Number of Pages: 11p; Illustrations: 6 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107334941
T1 - Advanced nursing practice with the Indian health service.
AU - Phillips RK
Y1 - 1997/03//1997 Mar
N1 - Accession Number: 107334941. Language: English. Entry Date: 19970901. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9100939.
KW - Advanced Nursing Practice
KW - Native Americans
KW - United States Public Health Service
KW - Cultural Diversity
KW - Maternal-Child Health
SP - 36
EP - 39
JO - Nurse Practitioner Forum
JF - Nurse Practitioner Forum
JA - NURSE PRACT FORUM
VL - 8
IS - 1
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Work with the US Indian Health Service is an exciting and rewarding experience. It allows family nurse practitioners the opportunity to use a wide range of skills and to develop true family and community involvement. Copyright (C) 1997 by W.B. Saunders Company
SN - 1045-5485
AD - Santa Clara Health Center, Santa Fe Service Unit, US Indian Health Service, Espanola, NM
U2 - PMID: 9239002.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107334941&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107350597
T1 - Management. Safety in the Alaskan wilderness.
AU - Carter GW
Y1 - 1997/03//
N1 - Accession Number: 107350597. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; anecdote. Journal Subset: Consumer Health; USA. NLM UID: 7610574.
KW - United States Public Health Service
KW - Occupational Hazards -- Alaska
KW - Alaska
KW - Air Travel
SP - 22
EP - 81
JO - Occupational Health & Safety
JF - Occupational Health & Safety
JA - OCCUP HEALTH SAF
VL - 66
IS - 3
CY - Chatsworth, California
PB - 1105 Media, Inc.
SN - 0362-4064
AD - United States Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107340540
T1 - Special section on homelessness. Creating integrated service systems for homeless persons with mental illness: the ACCESS program.
AU - Randolph F
AU - Blasinsky M
AU - Leginski W
AU - Parker LB
AU - Goldman HH
Y1 - 1997/03//
N1 - Accession Number: 107340540. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Community Networks -- Administration
KW - Health Care Delivery -- Administration
KW - Homeless Persons
KW - Mental Disorders -- Complications
KW - Mental Disorders -- Rehabilitation
KW - Mental Health Services -- Administration
KW - Social Welfare
KW - Health Care Delivery -- Methods
KW - Financial Support
KW - Interinstitutional Relations
KW - Multidisciplinary Care Team -- Administration
KW - Program Evaluation -- Methods
KW - United States
KW - Adult
SP - 369
EP - 373
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 48
IS - 3
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - The Access to Community Care and Effective Services and Supports (ACCESS) demonstration program was initiated in 1993 by the U.S. Department of Health and Human Services as part of a national agenda to end homelessness among persons with serious mental illness. Demonstration projects have been established in nine states to develop integrated systems of care for this population. This paper provides an overview of the ACCESS program and presents definitions of services integration and systems integration. Evaluating the effectiveness of integration strategies is a critical aspect of the program. The authors describe the evaluation design and the integration strategies being evaluated and summarize findings from a formative evaluation of the project's first two years. The evaluation revealed several problems that were addressed by providing technical assistance to the states. States were helped to articulate a broader mission of addressing system-level barriers, develop an expanded plan, strengthen the authority of interagency councils, involve leaders at the state and agency levels, and develop joint funding strategies.
SN - 1075-2730
AD - Center for Mental Health Services, 5600 Fishers Lane, Room 11C-05, Rockville, MD 20857
U2 - PMID: 9057240.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107340540&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107323364
T1 - CDRH summary report. FDA summarizes radiation therapy device problems.
AU - Kaczmarek RV
Y1 - 1997///Spring1997
N1 - Accession Number: 107323364. Language: English. Entry Date: 19970501. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9206619.
KW - Radiotherapy -- Equipment and Supplies
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 65
EP - 65
JO - Radiation Therapist
JF - Radiation Therapist
JA - RADIAT THERAPIST
VL - 6
IS - 1
CY - Alburquerque, New Mexico
PB - American Society of Radiologic Technologists
SN - 1084-1911
AD - FDA's Center for Devices and Radiological Health
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105824588
T1 - An in vitro evaluation of condoms as barriers to a small virus.
AU - Lytle CD
AU - Routson LB
AU - Seaborn GB
AU - Dixon LG
AU - Bushar HF
AU - Cyr WH
Y1 - 1997/03//
N1 - Accession Number: 105824588. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7705941.
KW - Condoms
KW - Viruses -- Physiology
KW - Permeability
SP - 161
EP - 164
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 24
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20857, USA.
U2 - PMID: 9132983.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105824588&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Wagner, J. Christopher
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Asbestos-Related Cancer and the Amphibole Hypothesis 1. The First Documentation of the Association.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/04//
VL - 87
IS - 4
M3 - Letter
SP - 687
EP - 688
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor in response to an annotation and a paper about asbestos-related cancer and the amphibole hypothesis and a response by L. T. Stayner, D. A. Dankovic and R. A. Lemen are presented.
KW - Asbestos
KW - Letters to the editor
KW - Cancer
KW - Amphiboles
KW - Heat resistant materials
N1 - Accession Number: 20709638; Wagner, J. Christopher 1; Stayner, Leslie T. 2; Dankovic, David A. 2; Lemen, Richard A.; Affiliations: 1: FRCPath, FFOM; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Apr97, Vol. 87 Issue 4, p687; Thesaurus Term: Asbestos; Subject Term: Letters to the editor; Subject Term: Cancer; Subject Term: Amphiboles; Subject Term: Heat resistant materials; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Mossman, Brooke T.
AU - Gee, J. Bernard L.
AU - Cullen, Mark R.
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Asbestos-Related Cancer and the Amphibole Hypothesis 4. The Hypothesis Is Still Supported by Scientists and Scientific Data.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/04//
VL - 87
IS - 4
M3 - Letter
SP - 689
EP - 691
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Annotation: The Amphibole Hypothesis of Asbestos-Related Cancer--Gone But Not Forgotten," by M. R. Cullen in the 1996 issue.
KW - Asbestos
KW - Letters to the editor
N1 - Accession Number: 20709648; Mossman, Brooke T. 1; Gee, J. Bernard L. 2; Cullen, Mark R. 3; Stayner, Leslie T. 4; Dankovic, David A. 4; Lemen, Richard A.; Affiliations: 1: University of Vermont College of Medicine, Burlington; 2: Yale University School of Medicine, New Haven, Conn.; 3: School of Medicine, Yale University, New Haven, Conn.; 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Apr97, Vol. 87 Issue 4, p689; Thesaurus Term: Asbestos; Subject Term: Letters to the editor; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grant, Katharyn A.
T1 - Shrawan Kumar and Anil Mital (eds): Electromyography in ergonomics.
JO - Human Factors & Ergonomics in Manufacturing
JF - Human Factors & Ergonomics in Manufacturing
Y1 - 1997///Spring1997
VL - c7
IS - 2
M3 - Book Review
SP - 155
EP - 156
SN - 10908471
AB - Reviews the book "Electromyography in Ergonomics," edited by Shrawan Kumar and Anil Mital.
KW - Electromyography
KW - Nonfiction
KW - Kumar, Shrawan
KW - Mital, Anil
KW - Electromyography in Ergonomics (Book)
N1 - Accession Number: 13361239; Grant, Katharyn A. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, OH; Issue Info: Spring1997, Vol. c7 Issue 2, p155; Subject Term: Electromyography; Subject Term: Nonfiction; Reviews & Products: Electromyography in Ergonomics (Book); People: Kumar, Shrawan; People: Mital, Anil; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107326844
T1 - Guest editorial. Nurses should take action to avoid occupational latex allergy.
AU - Petsonk EL
Y1 - 1997/04//1997 Apr
N1 - Accession Number: 107326844. Language: English. Entry Date: 19970601. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7605913.
KW - Latex Hypersensitivity -- Prevention and Control
KW - Occupational Exposure -- Prevention and Control
SP - 91
EP - 92
JO - JEN: Journal of Emergency Nursing
JF - JEN: Journal of Emergency Nursing
JA - J EMERG NURS
VL - 23
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 0099-1767
AD - Clinical Section, Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
U2 - PMID: 9216274.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107326844&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Kamerow, Douglas B.
T1 - Before and After Guidelines.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1997/04//
VL - 44
IS - 4
M3 - Editorial
SP - 344
EP - 346
SN - 00943509
AB - The author argues that the health care sector should pay attention to what happens before and after clinical practice guidelines. He cites the various factors that have contributed to the growth of guidelines in the U.S. and these include the increase in health care costs and the variation in the delivery of health care services by region and medical specialty. He mentioned that the U.S. Agency for Health Care Policy and Research has stopped developing guidelines.
KW - PHYSICIAN practice patterns
KW - GUIDELINES
KW - MEDICAL care
KW - MEDICAL care costs
KW - UNITED States. Agency for Health Care Policy & Research
KW - UNITED States
N1 - Accession Number: 9709251698; Kamerow, Douglas B. 1; Source Information: Apr1997, Vol. 44 Issue 4, p344; Subject: PHYSICIAN practice patterns; Subject: GUIDELINES; Subject: MEDICAL care; Subject: MEDICAL care costs; Subject: UNITED States. Agency for Health Care Policy & Research; Geographic Terms: UNITED States; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Andrews Jr., John S.
T1 - Public Health Issues in Risk Assessment Related to Environmental Hazards.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/04//
M3 - Article
SP - 366
EP - 366
SN - 00961736
N1 - Accession Number: 113379388; Andrews Jr., John S. 1; Source Information: Apr1997, p366; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 98
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107235448
T1 - A nurse practitioner-managed after-hours clinic for a native American reservation.
AU - Berry RA
Y1 - 1997/04//
N1 - Accession Number: 107235448. Language: English. Entry Date: 19980101. Revision Date: 20150819. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8916634.
KW - Nurse-Managed Centers -- Wyoming
KW - Native Americans -- Wyoming
KW - Nurse Practitioners
KW - Wyoming
KW - Health Care Costs
KW - Government Agencies
KW - Cost Savings
SP - 165
EP - 170
JO - Journal of the American Academy of Nurse Practitioners
JF - Journal of the American Academy of Nurse Practitioners
JA - J AM ACAD NURSE PRACT
VL - 9
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The Indian Health Service implemented a plan for an after-hours clinic which has been providing services since May 1991 on the Wind River Indian Reservation in Wyoming. Integral to the plan for the after-hours clinic was the family nurse practitioner as primary care provider. The after-hours clinic expands the health care services of the clinic by 3 hours on weekdays and 8 hours on Sundays. The role of the nurse practitioner as a primary care provider was introduced to the Wind River Service Unit, along with an after-hours clinic operation. Since the inception of the after-hours clinic, behavioral health and dental services and a women's clinic have been added.
SN - 1041-2972
AD - United States Public Health Service Commissioned Corps, Indian Health Service, Wind River Service Unit, PO Box 128, Fort Washakie, WY 82514
U2 - PMID: 9274236.
DO - j.1745-7599.1997.tb01229.x10.1111/j.1745-7599.1997.tb01301.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107320228
T1 - Device errors. Infusion pump mishap.
AU - Parmentier C
Y1 - 1997/04//
N1 - Accession Number: 107320228. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Infusion Pumps -- Adverse Effects
KW - Equipment Failure -- Adverse Effects
KW - Equipment Safety
KW - Medication Errors
KW - Incident Reports
SP - 26
EP - 26
JO - Nursing
JF - Nursing
JA - NURSING
VL - 27
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9171646.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107320228&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105820300
T1 - Chaparral-associated hepatotoxicity.
AU - Sheikh NM
AU - Philen RM
AU - Love LA
Y1 - 1997/04/28/
N1 - Accession Number: 105820300. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Hepatitis -- Etiology
KW - Plants, Medicinal
KW - Adult
KW - Cholestasis -- Chemically Induced
KW - Disease Progression
KW - Female
KW - Hepatic Encephalopathy -- Chemically Induced
KW - Hepatitis -- Blood
KW - Hepatitis -- Complications
KW - Liver Cirrhosis -- Chemically Induced
KW - Male
KW - Middle Age
SP - 913
EP - 919
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 157
IS - 8
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA.
U2 - PMID: 9129552.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105820300&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Robertson, Leon S.
AU - Maloney, Angela
T1 - Motor Vehicle Rollover and Static Stability: An Exposure Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/05//
VL - 87
IS - 5
M3 - Article
SP - 839
EP - 839
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined vehicle rollovers in terms of site-specific exposure and speeds of vehicles of varying stability. Methods. Fifty-one rollover sites in two states were visited at the same time of day and day of week as the rollover. A sample of vehicles moving in the same direction as the rollover were observed, and vehicle-specific data were obtained from identification numbers. Results. Low stability, exacerbated by the addition of passengers, increased the risk of rollover. Speed was not correlated with stability and is not a confounder. Conclusions. Rollovers could be substantially reduced if motor vehicles were manufactured with a static stability of 1.2 or greater. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Motor vehicles
KW - Public health
KW - Transportation accidents
KW - Human services
KW - Accidents
N1 - Accession Number: 9707170148; Robertson, Leon S. 1,2; Maloney, Angela 3; Affiliations: 1: Department of Epidemiology and Public Health, Yale University, New Haven, Conn.; 2: Nanlee Research, New Haven, Conn.; 3: Indian Health Service, Tuba City, Ariz.; Issue Info: May97, Vol. 87 Issue 5, p839; Thesaurus Term: Motor vehicles; Thesaurus Term: Public health; Subject Term: Transportation accidents; Subject Term: Human services; Subject Term: Accidents; NAICS/Industry Codes: 415190 Recreational and other motor vehicles merchant wholesalers; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 1852
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Amandus, H. E.
AU - Hendricks, S. A.
AU - Zahm, D.
AU - Friedmann, R.
AU - Block, C.
AU - Wellford, C.
AU - Brensilber, D.
AU - Bynum, T.
AU - McManus, R.
AU - Malcan, J.
AU - Weiss, J. C.
AU - Kessler, D.
T1 - Convenience Store Robberies in Selected Metropolitan Areas.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/05//
M3 - Article
SP - 442
EP - 447
SN - 00961736
AB - Circumstances of injury were abstracted from police reports for 1835 convenience store robberies that occurred during 1992 or 1993 in selected metropolitan areas of seven eastern states. Subset analyses were performed using the data (758 robberies) from four states with relatively complete risk factor information. The purpose of this study was to estimate the risk of injury in a robbery situation for various risk factors. The overall risk of employee robbery-related injury could not be estimated because the probability of robbery is unknown. Of the 1835 robberies, 59% of the total robberies occurred at nighttime (9 p.m. to 3 a.m.), 47% occurred in stores previously robbed in the study period, 63% involved the use of a firearm, and 12% were associated with an injury to at least one employee. In the subset analysis of 758 robberies in four states, the employee probability of injury in a robbery was lower with firearm use compared with no weapon or use of a blunt instrument, and the probability of severe injury (defined as death, or an injury necessitating a trip to a hospital) was lower with a firearm compared with the use of a blunt instrument. However, all five fatalities were firearm-related. Other factors that were associated with a lower probability of employee injury included robbery occurrence in stores that had been robbed multiple times, compared with stores robbed only once; having 1 to 999 dollars stolen, compared with having no money stolen; and the presence of a customer(s) in the store at the time of the robbery. The employee risk of injury was not significantly different between one- (0.106) and multiple-employee (0.111) stores. Similarly, the employee risk of severe injury was not significantly different between one- (0.029) and multiple-employee stores (0.022). We conclude that there are several potential risk factors for employee injury in convenience store robberies, some of which are amenable to interventions. Further research on these factors and their relationship to employee injury is indicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379298; Amandus, H. E. 1; Hendricks, S. A. 1; Zahm, D. 1; Friedmann, R. 1; Block, C. 1; Wellford, C. 1; Brensilber, D. 1; Bynum, T. 1; McManus, R. 1; Malcan, J. 1; Weiss, J. C. 1; Kessler, D. 1; Source Information: May1997, p442; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3672
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107301024
T1 - Downsizing the physician workforce.
AU - McClendon BJ
AU - Politzer RM
AU - Christian E
AU - Fernandez ES
Y1 - 1997/05//May/Jun97
N1 - Accession Number: 107301024. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Physicians -- Manpower
KW - Health Services Needs and Demand
KW - Specialties, Medical -- Manpower
KW - Data Analysis -- Methods
KW - American Medical Association
KW - Health Services Research
KW - Descriptive Statistics
KW - Confidence Intervals
KW - Managed Care Programs
KW - Health Maintenance Organizations
KW - Education, Medical
KW - Human
SP - 231
EP - 239
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 112
IS - 3
PB - Sage Publications Inc.
AB - Objective. To estimate the need for downsizing the physician workforce in a changing health care environment. Methods. First, assuming that 1993 physician-to-population ratios would be maintained, the authors derived downsizing estimates by determining the annual growth in the supply of specialists necessary to maintain these ratios (sum of losses from death and retirement plus increase necessary to parallel population growth) and compared them with an estimate of the number of new physicians being produced (average annual number of board certificates issued between 1990 and 1994). Then, assuming that workforce needs would change in a system increasingly dominated by managed care, the authors estimated specialty-specific downsizing needs for a managed care-dominated environment using data from several sources. Results. To maintain the 1993 199.6 active physicians per 100,000 population ratio, 14,644 new physicians would be needed each year. Given that an average of 20,655 physicians were certified each year between 1990 and 1994, at least 601 1 fewer new physicians were needed annually to maintain 1993 levels. To maintain the 132.2 ratio of active non-primary care physicians per 100,000 population, the system needed to produce 9698 non-primary care physicians per year, because an average of 14,527 new non-primary care physicians entered the workforce between 1990 and 1994, downsizing by 4829, or 33%, was needed. To maintain the 66.8 active primary care physicians per 100,000 population ratio, 4946 new primary care physicians were needed per year since primary care averaged 6 128 new certifications per year, a downsizing of 1 182, or 20%, was indicated. Only family practice, neurosurgery, otolaryngology, and urology did not require downsizing. Seventeen medical and hospital-based specialties, including 7 of 10 internal medicine subspecialties, needed downsizing by at least 40%. Less downsizing in general was needed in the surgical specialties and in psychiatry. A managed care dominated-system would call for greater downsizing in most of the non-primary care specialties. Conclusion. These data support the need for downsizing the nation's physician supply, especially in the internal medicine subspecialties and hospital support specialties and to a lesser extent among surgeons and primary care physicians.
SN - 0033-3549
AD - Bureau of Health Professions, Health Resources and Services Administration, Rockville, MD
U2 - PMID: 9160058.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107301024&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - The larger threat of infectious diseases.
AU - Pinner, Robert W.
JO - Society
JF - Society
Y1 - 1997/05//May/Jun97
VL - 34
IS - 4
SP - 42
EP - 43
SN - 01472011
N1 - Accession Number: 9706042656; Author: Pinner, Robert W.: 1 ; Author Affiliation: 1 Special assistant for surveillance, Office of the Director of the National Center for Infectious Diseases, Public Health Service of the Department of Health and Human Services; No. of Pages: 2; Language: English; Publication Type: Article; Update Code: 20050621
N2 - Presents a response to a criticism of an article that reports trends in infectious disease mortality in the U.S. which appeared in a 1996 issue of the "Journal of the American Medical Association." Reason for choosing mortality as the outcome measure of the study; Events that exemplify the volatility of infectious diseases, reinforcing the importance of public health preparedness; Stance regarding the critics' observation that HIV/AIDS and the aging population contributed to these trends.
KW - *COMMUNICABLE diseases
KW - *MORTALITY
KW - *HIV infections
KW - *AIDS (Disease)
KW - *PUBLIC health
KW - TRENDS
KW - OUTCOME assessment (Medical care)
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107271966
T1 - Asbestosis and silicosis.
AU - Wagner GR
Y1 - 1997/05/03/
N1 - Accession Number: 107271966. Language: English. Entry Date: 19980701. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Pneumoconiosis
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Diseases
KW - Risk Factors
KW - Pneumoconiosis -- Radiography
KW - Pneumoconiosis -- Therapy
KW - Lung Neoplasms
KW - Mesothelioma
KW - Asbestos -- Adverse Effects
KW - Disease Surveillance
KW - Pneumoconiosis -- Etiology
SP - 1311
EP - 1315
JO - Lancet
JF - Lancet
JA - LANCET
VL - 349 North American Edition
IS - 9061
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505
U2 - PMID: 9142077.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107271966&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107238212
T1 - Counseling the pregnant worker.
AU - Ebner J
Y1 - 1997/05/05/1997 May 5
N1 - Accession Number: 107238212. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Nursing; USA. NLM UID: 9421079.
KW - Occupational Health Nursing
KW - Women, Working -- In Pregnancy
KW - Pregnancy
KW - Female
SP - 15
EP - 15
JO - Nursing Spectrum -- Washington DC & Baltimore Edition
JF - Nursing Spectrum -- Washington DC & Baltimore Edition
JA - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL - 7
IS - 9
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1098-9153
AD - Public Health Service, New Carrollton, MD
U2 - PMID: 9431230.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107238212&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107332253
T1 - Commentary. Never lose heart?
AU - Harrison P
Y1 - 1997/06//1997 Jun
N1 - Accession Number: 107332253. Language: English. Entry Date: 19970801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8403379.
KW - Home Nursing, Professional -- Trends
KW - Nursing Care
KW - Home Health Agencies -- Administration
SP - 448
EP - 448
JO - Home Healthcare Nurse
JF - Home Healthcare Nurse
JA - HOME HEALTHC NURSE
VL - 15
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0884-741X
AD - Washington County Public Health Service, Hudson Falls, New York
U2 - PMID: 9223995.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107332253&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104794769
T1 - Another look at emergency room overcrowding: accessibility of the health services and quality of care.
AU - Lombrail, P
AU - Vitoux-Brot, C
AU - Bourrillon, A
AU - Brodin, M
AU - De Pouvourville, G
Y1 - 1997/06//1997 Jun
N1 - Accession Number: 104794769. Language: English. Entry Date: 20110610. Revision Date: 20161117. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9434628.
KW - Emergency Service -- Utilization
KW - Health Services Accessibility
KW - Hospitals, Pediatric -- Standards
KW - Hospitals, Pediatric -- Utilization
KW - Quality Assurance
KW - Child, Preschool
KW - Female
KW - Human
KW - Infant
KW - Insurance Coverage
KW - Insurance, Health
KW - Logistic Regression
KW - Male
KW - Multivariate Analysis
KW - Odds Ratio
KW - France
KW - Socioeconomic Factors
KW - Immunization -- Utilization
SP - 225
EP - 235
JO - International Journal for Quality in Health Care
JF - International Journal for Quality in Health Care
JA - INT J QUAL HEALTH CARE
VL - 9
IS - 3
PB - Oxford University Press / USA
AB - Purpose: To describe both the social characteristics and the health needs of the medical users of a pediatric hospital Emergency Room with special emphasis on frequent use.Study Selection: Observational study on health services utilization and health care needs of young children consulting at a teaching hospital's Emergency Room.Data Sources: Mother interview and medical record review.Results Of Data Synthesis: Children from underprivileged strata are more often high Emergency Room users. Their preventive needs are satisfied but adequate follow-up of their medical problems is more often lacking.Conclusion: To understand why some achievable benefits are not achieved it is necessary to evaluate the varying performance of health services according to the social origin of the users.
SN - 1353-4505
AD - Public Health Service, Robert Debré Hospital, Paris, France.
U2 - PMID: 9209921.
DO - intqhc/9.3.225
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107234430
T1 - Contraceptive choices -- you can help.
AU - Schnare S
AU - Matsuda KJ
Y1 - 1997/06//1997 Jun
N1 - Accession Number: 107234430. Language: English. Entry Date: 19980101. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9012341.
KW - Contraception
KW - Contraceptive Agents
KW - Contraceptive Devices
KW - Product Evaluation
KW - Sexual Counseling -- In Adolescence
KW - Contraceptives, Oral
KW - Intrauterine Devices
KW - Breast Feeding
KW - Postnatal Period
KW - Menopause
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Pregnancy
KW - Male
KW - Female
SP - 11
EP - 19
JO - Office Nurse
JF - Office Nurse
JA - OFFICE NURSE
VL - 10
IS - 6
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
AB - Helping patients choose the right birth control method requires a familiarity with current options and current research.
SN - 0893-6595
AD - U.S. Department of Health and Human Services' Public Health Service, Seattle
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107234430&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107338958
T1 - Clip & file. Dx-ray... clostridial myonecrosis (gas gangrene)
AU - Carlucci GJ
Y1 - 1997/06//1997 Jun
N1 - Accession Number: 107338958. Language: English. Entry Date: 19971001. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8403486.
KW - Gas Gangrene -- Diagnosis
KW - Amputation Stumps
KW - Amputees
KW - Below-Knee Amputation
KW - Gas Gangrene -- Therapy
KW - Middle Age
KW - Male
SP - 151
EP - 152
JO - Physician Assistant
JF - Physician Assistant
JA - PHYSICIAN ASSIST
VL - 21
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 8750-7544
AD - Indian Health Service, Department of Emergency Medicine, Crownpoint, New Mexico
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hitch, W.L.
AU - Eberhard, M.L.
AU - Lammie, P.J.
T1 - Investigation of the influence of maternal infection with Wuchereria bancrofti on the humoral and cellular responses of neonates to filarial antigens.
JO - Annals of Tropical Medicine & Parasitology
JF - Annals of Tropical Medicine & Parasitology
Y1 - 1997/07//
VL - 91
IS - 5
M3 - Article
SP - 461
PB - Taylor & Francis Ltd
SN - 00034983
AB - Epidemiological data indicate that maternal filarial infection might be associated with increased susceptibility to filarial infection in offspring. To examine the influence of maternal infection on development of antifilarial immunity in neonates, paired cord and maternal sera and mononuclear cells were collected in an area where Wuchereria bancrofti infection is endemic. Anti-filarial humoral responses (IgG, IgM and IgE), non-parasite-specific humoral responses (total IgE), proliferation induced by filarial antigen and production of cytokines (interleukin-2, interleukin-4 and interferon-g) were all monitored. Few cord serum samples had detectable antifilarial IgM or IgE and neither these responses nor total IgE levels differed as a function of maternal infection status. Of cord-blood mononuclear cells assayed, a relatively small proportion exhibited reactivity to filarial antigens. Based on these limited responses to filarial antigens, few neonates display evidence of in-utero sensitization to filarial antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Medicine & Parasitology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Filariasis
KW - Maternal-fetal exchange
KW - Newborn infants
N1 - Accession Number: 7620646; Hitch, W.L. 1; Eberhard, M.L. 2; Lammie, P.J. 2; Email Address: pjll@cdc.gov; Affiliations: 1: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, U.S.A.; 2: Division of Parasitic Diseases, National Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, U.S.A.; Issue Info: Jul1997, Vol. 91 Issue 5, p461; Thesaurus Term: DISEASES; Subject Term: Filariasis; Subject Term: Maternal-fetal exchange; Subject Term: Newborn infants; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/00034989760824
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107191204
T1 - In vitro testing of pacemakers for digital cellular phone electromagnetic interference.
AU - Ruggera PS
AU - Witters DM
AU - Bassen HI
AU - Ruggera, P S
AU - Witters, D M
AU - Bassen, H I
Y1 - 1997/07//1997 Jul-Aug
N1 - Accession Number: 107191204. Language: English. Entry Date: 19990601. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Wireless Communications
KW - Pacemaker, Artificial
KW - Electromagnetic Fields
KW - In Vitro Studies
KW - Data Analysis, Statistical
KW - Human
SP - 358
EP - 371
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 31
IS - 4
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
SN - 0899-8205
AD - Center for Devices and Radiological Health, Rockville, MD 20852, USA
AD - Food and Drug Administration HFZ-133, Center for Devices and Radiological Health, 12721 Twinbrook Parkway, Rockville, MD 20852
U2 - PMID: 9262836.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104795263
T1 - Covering mental health and substance abuse services.
AU - Buck, J A
AU - Umland, B
Y1 - 1997/07//Jul/Aug1997
N1 - Accession Number: 104795263. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Insurance Coverage -- Trends
KW - Insurance, Health -- Trends
KW - Mental Health Services -- Economics
KW - Forecasting
KW - Insurance, Health -- Legislation and Jurisprudence
KW - Health Maintenance Organizations -- Legislation and Jurisprudence
KW - Health Maintenance Organizations -- Trends
KW - Insurance Coverage -- Legislation and Jurisprudence
KW - Mental Disorders -- Economics
KW - Mental Disorders -- Rehabilitation
KW - Mental Health Services -- Legislation and Jurisprudence
KW - Social Welfare -- Economics
KW - Substance Use Disorders -- Economics
KW - Substance Use Disorders -- Rehabilitation
KW - United States
SP - 120
EP - 126
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 16
IS - 4
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
SN - 0278-2715
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA.
U2 - PMID: 9248155.
DO - 10.1377/hlthaff.16.4.120
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104795263&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104795265
T1 - Characteristics and growth of managed behavioral health care firms.
AU - Kihlstrom, L C
Y1 - 1997/07//Jul/Aug1997
N1 - Accession Number: 104795265. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Behavior Therapy -- Economics
KW - Insurance, Health -- Trends
KW - Managed Care Programs -- Administration
KW - Mental Health Services -- Economics
KW - Behavior Therapy -- Trends
KW - Cost Control -- Trends
KW - Forecasting
KW - Insurance, Health -- Economics
KW - Managed Care Programs -- Economics
KW - Managed Care Programs -- Trends
KW - Mental Disorders -- Economics
KW - Mental Disorders -- Rehabilitation
KW - Social Welfare -- Economics
KW - Substance Use Disorders -- Economics
KW - Substance Use Disorders -- Rehabilitation
KW - United States
SP - 127
EP - 130
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 16
IS - 4
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
SN - 0278-2715
AD - Center for Mental Health Services Research, University of California, Berkeley, USA.
U2 - PMID: 9248156.
DO - 10.1377/hlthaff.16.4.127
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104795265&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - DRUG USE DURING PREGNANCY.
AU - Hutchins, Ellen
JO - Journal of Drug Issues
JF - Journal of Drug Issues
Y1 - 1997///Summer97
VL - 27
IS - 3
SP - 463
EP - 485
SN - 00220426
N1 - Accession Number: 9710102078; Author: Hutchins, Ellen: 1 ; Author Affiliation: 1 Health care administrator, Department of Health and Human Services Maternal and Child Health Bureau, Rockville, Maryland; No. of Pages: 23; Language: English; Publication Type: Article; Update Code: 20060215
N2 - Prevention and intervention services for pregnant, drug-using women have often developed prior to gaining empirical data on the antecedents of prenatal drug use. These data are important to address some of the underlying factors of drug use during pregnancy. A review of the literature indentified at least six categories of psychosocial risk factors that have been investigated as relevant to drug use among women, including pregnant women. These factors include: (1) history of childhood sexual abuse, (2) family history of alcohol or drug problems, (3) male partner's alcohol or drug use, (4) current depression, (5) social support, and (6) homelessness or transiency. An examination of these psychosocial risk factors indicates that the existing literature on these factors in drug use is limited by a lack of methodological rigor, resulting in large variations in prevalence rates due to factors such as definition. This paper summarizes the existing literature and methodological issues regarding the relation between psychosocial risk factors and drug use among women, including pregnant women. It also discusses some of the limitations and issues in assessing prenatal drug use with a particular focus on self-report and urine toxicologies. ABSTRACT FROM AUTHOR
KW - *PREGNANT women
KW - *ALCOHOLISM
KW - *DRUG abuse
KW - DRUG use
KW - PSYCHOSOCIAL factors
KW - CHILD sexual abuse
KW - SOCIAL support
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=9710102078&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107346931
T1 - Multirooted anomalies in the primary dentition of Native Americans.
AU - Winkler MP
AU - Ahmad R
Y1 - 1997/07//
N1 - Accession Number: 107346931. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060.
KW - Tooth Abnormalities
KW - Dentition, Primary -- Abnormalities
KW - Tooth Root -- Abnormalities -- In Infancy and Childhood
KW - Native Americans
KW - Cuspid -- Abnormalities
KW - Molar -- Abnormalities
KW - Child, Preschool
KW - Female
KW - Male
SP - 1009
EP - 1011
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 128
IS - 7
CY - Chicago, Illinois
PB - American Dental Association
AB - The dental literature contains a small number of reports of primary multirooted anomalies and even fewer reports on the clinical significance of these findings. When conducting routine clinical examinations, the authors found multirooted anomalies in three Native American children. The anomalies included a primary bifurcated maxillary left canine, a primary three-rooted mandibular right first molar and bilateral primary three-rooted mandibular first and second molars. The clinical significance of these types of anomalies is discussed.
SN - 0002-8177
AD - Indian Health Service, S.I.P.I. Dental Clinic, P.O. Box 67830, Albuquerque, N.M. 87193
U2 - PMID: 9231606.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107346931&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107331519
T1 - Device errors. Disposable devices: time for a change.
AU - Parmentier C
AU - Webb C
Y1 - 1997/07//
N1 - Accession Number: 107331519. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety
KW - Disposable Equipment
KW - Product Labeling
KW - Time Factors
SP - 30
EP - 30
JO - Nursing
JF - Nursing
JA - NURSING
VL - 27
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107331519&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107185350
T1 - Intake of nutrients related to cardiovascular disease risk among three groups of American Indians: the Strong Heart Dietary Study.
AU - Zephier EM
AU - Ballew C
AU - Mokdad A
AU - Mendlein J
AU - Smith C
AU - Yeh JL
AU - Lee E
AU - Welty TK
AU - Howard B
AU - Zephier, E M
AU - Ballew, C
AU - Mokdad, A
AU - Mendlein, J
AU - Smith, C
AU - Yeh, J L
AU - Lee, E
AU - Welty, T K
AU - Howard, B
Y1 - 1997/07//1997 Jul-Aug
N1 - Accession Number: 107185350. Language: English. Entry Date: 19990501. Revision Date: 20161127. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Indian Health Service, Office of Planning and Legislation. NLM UID: 0322116.
KW - Native Americans
KW - Food Habits
KW - Cardiovascular Risk Factors
KW - Funding Source
KW - Arizona
KW - Oklahoma
KW - South Dakota
KW - North Dakota
KW - Cross Sectional Studies
KW - Diet Records
KW - Research Subject Recruitment
KW - Interviews
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Human
SP - 508
EP - 515
JO - Preventive Medicine
JF - Preventive Medicine
JA - PREV MED
VL - 26
IS - 4
CY - Burlington, Massachusetts
PB - Academic Press Inc.
AB - Background: Although diet is implicated in the elevated rate of cardiovascular disease among some American Indian tribes, the dietary intakes of these individuals have not been described. The Strong Heart Dietary Study compared diets of 10 tribes in Arizona, Oklahoma, and the Dakotas to examine the possible contribution of diet to cardiovascular and other chronic diseases.Methods: During 1988-1991, 892 people responded to a 24 hr diet recall questionnaire. Nutrient intake by study area, sex, and age group were compared by analysis of variance, and intakes were compared with nutrient intakes reported by participants in Phase 1 of the Third National Health and Nutrition Examination Survey and with dietary recommendations of the National Research Council, the American Heart Association, and the Healthy People 2000 objectives.Results: The intake of energy and nutrients varied significantly by sex and age. Men consumed more energy, macronutrients, and sodium than did women (P < or = 0.001). Women's diets were denser in carbohydrate, beta-carotene, vitamin C, and vitamin E than were men's diets (P < or = 0.001). Younger participants consumed more energy, macronutrients, vitamin E, and sodium than did older participants (P < or = 0.001). Older participants had diets denser in protein and beta-carotene than did younger participants (P < or = 0.001). Energy intake did not differ significantly by study area, but men in Arizona consumed more energy from carbohydrate and less energy from total fat than did men elsewhere (P < or = 0.01). Men and women in Arizona consumed more cholesterol and fiber than did other participants (P < or = 0.01) and less of the antioxidant vitamins (P < or = 0.01). Participants in the Strong Heart Diet Study reported diets higher in fats and cholesterol than did participants in Phase 1 of the Third National Health and Nutrition Examination Survey. Few Strong Heart participants achieved dietary recommendations for the reduction of risk of chronic disease.Conclusions: Area differences in nutrient intake were observed, but most participants consumed diets associated with increased risk of heart disease and other chronic diseases. Women and older participants in general reported healthier nutrient intakes. Dietary intervention programs should educate American Indians about dietary modifications to reduce the risk of cardiovascular and other nutrition-related disorders.
SN - 0091-7435
AD - Indian Health Service, Aberdeen Area Office, South Dakota 57401, USA
AD - Indian Health Service, Aberdeen Area Office, 115 4th Avenue Se, Aberdeen, South Dakota 57401
U2 - PMID: 9245673.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107185350&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107253041
T1 - Use of National Practitioner Data Bank disclosure information for decision making.
AU - Oshel RE
AU - Chen VT
AU - Cohen RL
AU - Lynch BS
Y1 - 1997///1997 Summer
N1 - Accession Number: 107253041. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Health Services Administration; Nursing; Peer Reviewed; USA. NLM UID: 9306156.
KW - National Practitioner Data Bank
KW - Staff Privileges
KW - Licensure
KW - Personnel Selection
KW - Surveys
KW - Interviews
KW - Prospective Studies
KW - Questionnaires
KW - Human
SP - 34
EP - 42
JO - Quality Management in Health Care
JF - Quality Management in Health Care
JA - QUAL MANAGE HEALTH CARE
VL - 5
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1063-8628
AD - Senior Analyst and Research Director, Division of Quality Assurance, Bureau of Health Professions, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD
U2 - PMID: 10169783.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107253041&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107255808
T1 - Comparative sensitivity of 13 species of pathogenic bacteria to seven chemical germicides.
AU - Sagripanti J
AU - Eklund CA
AU - Trost PA
AU - Jinnenman KC
AU - Abeyta C Jr.
AU - Kaysner CA
AU - Hill WE
Y1 - 1997/08//1997 Aug
N1 - Accession Number: 107255808. Language: English. Entry Date: 19980501. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Disinfectants
KW - Bacteria
KW - Cross Infection -- Prevention and Control
KW - Microbiological Techniques
KW - In Vitro Studies
KW - Descriptive Statistics
KW - Data Analysis Software
KW - Survival
KW - Human
SP - 335
EP - 339
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 25
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: The relative resistance of diverse human bacterial pathogens to commonly used germicidal agents has not been established. METHODS: We measured by titration the survival of thirteen different bacteria after exposure to glutaraldehyde, formaldehyde, hydrogen peroxide, peracetic acid, cupric ascorbate, sodium hypochlorite, or phenol. RESULTS: Our comparative experiments allowed classification of the organisms' survival into four groups: (a) Pseudomonas aeruginosa and Staphylococcus aureus showed the most resistance, (b) Clostridium perfringens, Salmonella typhimurium, Staphylococcus epidermidis, and Escherichia coli O157:H7 showed intermediate resistance, (c) Listeria monocytogenes, Shigella sonnei, and Vibrio parahaemolyticus survived some treatments with chemical agents only in the presence of protecting protein (serum albumin), and (d) Vibrio cholerae, Vibrio vulnificus, Bacillus cereus, and Yersinia enterocolitica did not survive any of the treatments applied. CONCLUSION: We found species that more frequently survived exposure to germicidal agents were also those most commonly reported in association with hospital infections. Our findings suggest that resistance to disinfectants may be more important than pathogenicity in determining the relative prominence of an organism as an agent responsible for nosocomial infections.
SN - 0196-6553
AD - Molecular Biology Branch, Center for Devices and Radiological Health, Food and Drug Administration, 5600 Fishers Ln, Rockville, MD 20857
U2 - PMID: 9276546.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Davis, Harold
AU - Schoendorf, Kenneth C.
AU - Gergen, Peter J.
AU - Moore Jr., Roscoe M.
T1 - National trends in mortality of children with sickle cell disease, 1968 through 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/08//
VL - 87
IS - 8
M3 - Article
SP - 1317
EP - 1322
PB - American Public Health Association
SN - 00900036
AB - The article presents a study which describes national trends in mortality of children with sickle cell disease and the settings in which death occurred in the United States. Deaths were included that had any cause coded for sickle cell disease. A preliminary analysis compared the and observed number of deaths from trauma, congenital anomalies, and perinatal conditions, assuming that African American children with sickle cell disease had the same mortality rate from these causes as children without the disease. The analysis suggested that children with sickle cell diseases who died of these causes often did not have sickle cell disease listed on their death certificates. For that reason, and to focus on deaths due to sickle cell disease, researchers excluded deaths having an underlying cause coded as trauma or any cause coded as congenital anomaly or perinatal condition. Since the mid-1960s, young children with sickle cell disease have been known to have an increased risk of severe bacterial diseases, especially those resulting from S. pneumoniae.
KW - Bacterial diseases
KW - Sickle cell anemia
KW - Juvenile diseases
KW - Death
KW - African American children
KW - Perinatology
N1 - Accession Number: 9709302465; Davis, Harold 1; Schoendorf, Kenneth C. 2; Gergen, Peter J.; Moore Jr., Roscoe M. 3; Affiliations: 1: Food Drug Administration, Rockville, MD.; 2: Infant and Child Health Studies Branch, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md.; 3: Office International and Refugee Health, Office of the Secretary, US Department of Health and Human Services, Rockville, MD.; Issue Info: Aug1997, Vol. 87 Issue 8, p1317; Thesaurus Term: Bacterial diseases; Subject Term: Sickle cell anemia; Subject Term: Juvenile diseases; Subject Term: Death; Subject Term: African American children; Subject Term: Perinatology; Number of Pages: 6p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 4822
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Whelan, Elizabeth A.
AU - Piacitelli, Greg M.
AU - Gerwel, Barbara
AU - Schnorr, Teresa M.
AU - Mueller, Charles A.
AU - Gittleman, Janie
AU - Matte, Thomas D.
T1 - Elevated blood lead levels in children of construction workers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/08//
VL - 87
IS - 8
M3 - Article
SP - 1352
EP - 1358
PB - American Public Health Association
SN - 00900036
AB - The article presents a study which examined whether children of lead-exposed construction workers had higher blood lead levels than neighborhood control children. The objective of the current study was to examine an additional population at high risk for pediatric, lead poisoning, the young children of lead-exposed construction workers. Personal interviews were conducted with the adult who had primary responsibility for child care in the household to obtain information about the household. Interviews were also conducted with each worker to obtain specific information about job characteristics and work practices. Venous blood samples were collected from all children. Who had not yet reached their sixth birthday. Samples of dust, loose paint chips, and water at exposed and control homes were collected for determination of lead concentrations. It was found that among exposed families, the child's blood lead levels were significantly correlated with dust lead levels at most sampling locations in the home and automobile, but correlations between child's blood lead and environmental measures were not found for control families.
KW - Lead in the body
KW - Construction workers
KW - Blood analysis
KW - Lead poisoning in children
KW - Child care
KW - Job descriptions
N1 - Accession Number: 9709302473; Whelan, Elizabeth A. 1,2; Piacitelli, Greg M. 1,2; Gerwel, Barbara 3; Schnorr, Teresa M. 1,2; Mueller, Charles A. 1,2; Gittleman, Janie 1,2; Matte, Thomas D. 4; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health.; 2: Centers for Disease Control and Prevention, Cincinnati, Ohio.; 3: Occupational Disease and Injury Service, New Jersey State Department of Health and Senior Services, Trenton, NJ.; 4: Environmental and Occupational Health Sciences Institute, Piscataway, NJ.; Issue Info: Aug1997, Vol. 87 Issue 8, p1352; Subject Term: Lead in the body; Subject Term: Construction workers; Subject Term: Blood analysis; Subject Term: Lead poisoning in children; Subject Term: Child care; Subject Term: Job descriptions; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3583
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107275983
T1 - National trends in the mortality of children with sickle cell disease, 1968 through 1992.
AU - Davis H
AU - Schoendorf KC
AU - Gergen PJ
AU - Moore RM Jr.
Y1 - 1997/08//
N1 - Accession Number: 107275983. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Anemia, Sickle Cell -- Mortality -- In Infancy and Childhood
KW - Child Mortality -- Trends
KW - Blacks
KW - Record Review
KW - Descriptive Statistics
KW - Databases
KW - Anemia, Sickle Cell -- Epidemiology
KW - Infant
KW - Child, Preschool
KW - Child
KW - Male
KW - Female
KW - Human
SP - 1317
EP - 1322
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 87
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This paper describes national trends in mortality of children with sickle cell disease and the settings in which death occurred. METHODS: United States death certificate data from 1968 through 1992 were used to calculate mortality rates of Black children with sickle cell disease 1 to 14 years old. Deaths from trauma, congenital anomalies, and perinatal conditions were excluded. RESULTS: Between 1968 and 1992, mortality rates of Black children with sickle cell disease decreased 41% for 1- to 4-year-olds, 47% for 5- to 9-year-olds, and 53% for 10- to 14-year-olds. During 1986 through 1992, children who died before hospital admission accounted for 41% of deaths among 1- to 4-year-olds, 27% among 5- to 9-year-olds, and 12% among 10- to 14-year-olds. CONCLUSIONS: Survival of Black children with sickle cell disease has improved markedly since 1968. A substantial proportion of deaths continue to occur prior to hospital admission. Trends in sickle cell mortality can be monitored inexpensively with death-certificate data.
SN - 0090-0036
AD - Office of International and Refugee Health, Office of the Secretary, US Department of Health and Human Services, Rockville, MD
U2 - PMID: 9279267.
DO - 10.2105/AJPH.87.8.1317
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107275983&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107276009
T1 - Elevated blood lead levels in children of construction workers.
AU - Whelan EA
AU - Piacitelli GM
AU - Gerwel B
AU - Schnorr TM
AU - Mueller CA
AU - Gittleman J
AU - Matte TD
Y1 - 1997/08//
N1 - Accession Number: 107276009. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Occupational Exposure -- Adverse Effects
KW - Occupations and Professions
KW - Lead Poisoning -- In Infancy and Childhood
KW - New Jersey
KW - Data Analysis, Statistical
KW - Hematologic Tests
KW - Interviews
KW - Sampling Methods
KW - Infant
KW - Child, Preschool
KW - Child
KW - Human
SP - 1352
EP - 1355
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 87
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study examined whether children of lead-exposed construction workers had higher blood lead levels than neighborhood control children. METHODS: Twenty-nine construction workers were identified from the New Jersey Adult Blood Lead Epidemiology and Surveillance (ABLES) registry. Eighteen control families were referred by workers. Venous blood samples were collected from 50 children (31 exposed, 19 control subjects) under age 6. RESULTS: Twenty-six percent of workers children had blood lead levels at or over the Centers for Disease Control and Prevention action level of 0.48 mumol/L (10 micrograms/dL), compared with 5% of control children (unadjusted odds ratio = 6.1; 95% confidence interval = 0.9, 147.2). CONCLUSIONS: Children of construction workers may be at risk for excessive lead exposure. Health care providers should assess parental occupation as a possible pathway for lead exposure of young children.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, R-15, Cincinnati, OH 45226
U2 - PMID: 9279275.
DO - 10.2105/AJPH.87.8.1352
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107276009&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107276014
T1 - The underreporting of deaths of American Indian children in California, 1979 through 1993.
AU - Epstein M
AU - Moreno R
AU - Bacchetti P
Y1 - 1997/08//
N1 - Accession Number: 107276014. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Child Mortality -- California
KW - Native Americans -- In Infancy and Childhood -- California
KW - Infant Mortality -- California
KW - California
KW - Record Review
KW - Infant Mortality -- Trends -- California
KW - Race Factors -- Classification
KW - Data Analysis, Statistical
KW - Infant
KW - Child, Preschool
KW - Child
KW - Human
SP - 1363
EP - 1366
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 87
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study linked birth and death certificates to determine misclassification of deaths of American Indian children in California. METHODS: Birth records for 1979 to 1993 were matched with mortality records through a computerized system. RESULTS: The number of deaths to American Indians was estimated to be three to four times greater than that reported on death certificates. Children in urban counties and those who died before 1987 were more likely to be misclassified. CONCLUSIONS: California death certificates identify less than one third of the deaths among American Indian children. Adjusting for racial misclassification provides a more accurate accounting of child mortality among American Indians.
SN - 0090-0036
AD - Indian Health Service, Sacramento, Calif
U2 - PMID: 9279278.
DO - 10.2105/AJPH.87.8.1363
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107276014&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kisner, Suzanne M.
AU - Pratt, Stephanie G.
T1 - Occupational Fatalities Among Older Workers in the United States: 1980-1991.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/08//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - Workers aged 65 and older had a workplace fatality rate 2.6 times that of workers aged 16 to 64 for 1980 through 1991 (14.1 per 100,000 vs 5.4), according to National Traumatic Occupational Fatalities (NTOF) data. The highest rates were in mining, agriculture, and construction. Compared with younger workers, older men were at an elevated risk for fatalities caused by machines, and older women for fatal falls and homicide. Prevention efforts should focus on older workers in agricultural settings, as well as those at increased risk of workplace falls or violence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635163; Kisner, Suzanne M. 1; Pratt, Stephanie G. 1; Source Information: Aug1997, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4717
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107239779
T1 - Guest column. Those codes! Avoiding errors with MDR reports.
AU - Weick-Brady M
Y1 - 1997/08//1997 Aug
N1 - Accession Number: 107239779. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7810150.
KW - Mandatory Reporting
KW - Equipment Safety
KW - Product Surveillance
KW - Coding
KW - Incident Reports
KW - United States Food and Drug Administration
SP - 101
EP - 102
JO - Same-Day Surgery
JF - Same-Day Surgery
JA - SAME DAY SURG
VL - 21
IS - 8
CY - Atlanta, Georgia
PB - AHC Media LLC
SN - 0190-5066
AD - Center for Devices and Radiological Health, Office of Surveillance and Biometrics, US Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105361929
T1 - The importance of analytical procedures in regulatory control.
AU - Layloff T
Y1 - 1997/08//
N1 - Accession Number: 105361929. Language: English. Entry Date: 20090703. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8710745.
KW - Drugs -- Analysis
KW - Quality Assurance
KW - Drug and Narcotic Control -- Methods
KW - Information Resources
KW - United States Food and Drug Administration
KW - World Health Organization
SP - 128
EP - 130
JO - WHO Drug Information
JF - WHO Drug Information
JA - WHO DRUG INF
VL - 11
IS - 3
PB - World Health Organization
SN - 1010-9609
AD - Division of Drug Analysis, United States Food and Drug Administration, St Louis, MO, USA
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DB - rzh
ER -
TY - JOUR
AU - Braddee, Richard W.
AU - Myers, John R.
T1 - Logging-Type Fatalities in the U.S. Production Agriculture Industry, 1980-1992.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 1997/08/09/
VL - 4
IS - 3/4
M3 - Article
SP - 373
EP - 375
SN - 1059924X
AB - Logging activities such as felling trees for firewood and clearing farm land of trees, are conducted by many farmers throughout the country. According to the National Institute for Occupational Safety and Health (NIOSH), National Traumatic Occupational Fatalities (NTOF) surveillance system, these logging-type practices resulted in 173 work-related “struck by falling object” deaths to farmers during the years 1980 through 1992, which represent 46− of all struck-by-falling-object deaths in the agricultural production industry during this 13-year time period. The majority of these deaths occurred in the midwestern (41−) and southern (46−) regions of the United States. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76040723; Braddee, Richard W. 1; Myers, John R. 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA; Issue Info: Aug1997, Vol. 4 Issue 3/4, p373; Number of Pages: 3p; Document Type: Article
L3 - 10.1300/J096v04n03_22
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ER -
TY - JOUR
ID - 105820406
T1 - Glucocorticoidlike activity of megestrol. A summary of Food and Drug Administration experience and a review of the literature.
AU - Mann M
AU - Koller E
AU - Murgo A
AU - Malozowski S
AU - Bacsanyi J
AU - Leinung M
Y1 - 1997/08/11/
N1 - Accession Number: 105820406. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Antineoplastic Agents, Hormonal -- Adverse Effects
KW - Appetite Stimulating Agents -- Adverse Effects
KW - Glucocorticoids -- Adverse Effects
KW - Megestrol -- Adverse Effects
KW - Adrenal Insufficiency -- Chemically Induced
KW - Cushing's Syndrome -- Chemically Induced
KW - Diabetes Mellitus -- Chemically Induced
KW - United States Food and Drug Administration
KW - United States
SP - 1651
EP - 1656
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 157
IS - 15
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Md, USA.
U2 - PMID: 9250225.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105976080
T1 - Personal watercraft-related injuries. A growing public health concern.
AU - Branche CM
AU - Conn JM
AU - Annest JL
AU - Branche, C M
AU - Conn, J M
AU - Annest, J L
Y1 - 1997/08/27/
N1 - Accession Number: 105976080. Language: English. Entry Date: 20080215. Revision Date: 20161112. Publication Type: journal article; research. Commentary: Barach P, Baum E. Personal watercraft-related injuries. (JAMA) 2/11/98; 279 (6): 433-434. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Accidents
KW - Recreation
KW - Water
KW - Wounds and Injuries -- Epidemiology
KW - Adolescence
KW - Adult
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Male
KW - Middle Age
KW - Ships
KW - United States
KW - Human
SP - 663
EP - 665
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 278
IS - 8
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: An increase in the recreational use of personal watercraft (PWC) raises concern about an increase in associated injuries on a national level.Objective: To estimate the relative frequency, types of injury, and demographic features of persons injured while using PWC in the United States.Design: Case series.Setting: Emergency department (ED) visits to hospitals participating a national probability sample.Participants: All persons treated for PWC-related injury from January 1,1990, through December 31, 1995.Results: An estimated 32954 persons (95% confidence interval [CI], 22919-42989) with PWC-related injuries were treated in US hospital EDs, of which 3.5% were hospitalized. Personal watercraft-related injuries have increased significantly from an estimated 2860 in 1990 to more than 12000 in 1995. During this period, the number of PWC in operation increased 3-fold from approximately 241500 in 1990 to an estimated 760000 in 1995. The most prevalent diagnoses were lacerations, contusions, and fractures.Main Outcome Measures: The estimated number and percentage of patients treated in EDs for PWC-related injuries, by year, age, sex, and the number and rate per 1000 of PWC in operation by year.Conclusions: Since 1990, there has been at least a 4-fold increase in injuries associated with an increase in the recreational use of PWC. The rate of ED-treated injuries related to PWC was about 8.5 times higher (95% CI, 8.2-8.8; 1992 data) than the rate of those from motorboats. Specific training and adult supervision is recommended for minors using PWC. Furthermore, medical practitioners should encourage personal flotation device use and other protection for their patients who are known water enthusiasts.
SN - 0098-7484
AD - National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Ga 30341-3724, USA
U2 - PMID: 9272899.
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DB - rzh
ER -
TY - JOUR
AU - Hassett, Seth
AU - Austin, Michael J.
T1 - Service Integration: Something Old and Something New (Book).
JO - Administration in Social Work
JF - Administration in Social Work
Y1 - 1997/09//
VL - 21
IS - 3/4
M3 - Book Review
SP - 9
EP - 29
SN - 03643107
AB - The authors trace the definition and challenges of "service integration," variously known over time as "collaboration," "coordination," "human services integration," and "one-stop shopping." While the common use of service integration terminology currently may seem to indicate a consensus in favor of a broad systemic reform, motivations and expectations for service integration differ significantly among different players in the service system. The authors conclude that service integration cannot be defined by a particular service model or outcome, but instead should be conceived of as an ongoing reform process. This process, when well-designed and implemented with long-term vision, can reduce duplication, strengthen communities, and improve client outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Administration in Social Work is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN services
KW - SOCIAL change
KW - SHOPPING
KW - SOCIAL integration
N1 - Accession Number: 6766; Hassett, Seth 1; Austin, Michael J. 2; Affiliations: 1: Public Health Analyst, Center for Mental Health Services, Substance Abuse and Mental Health Administration, Washington, DC; 2: Professor, School of Social Welfare, University of California at Berkeley, Berkeley, CA 94720; Issue Info: 1997, Vol. 21 Issue 3/4, p9; Thesaurus Term: HUMAN services; Thesaurus Term: SOCIAL change; Thesaurus Term: SHOPPING; Subject Term: SOCIAL integration; Number of Pages: 21p; Document Type: Book Review
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ER -
TY - JOUR
AU - Peipins, Lucy A.
AU - Burnett, Carol
AU - Alterman, Toni
AU - Lalich, Nina
T1 - Mortality patterns among female nurses: A 27-state study, 1984 through 1990.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/09//
VL - 87
IS - 9
M3 - Article
SP - 1539
EP - 1543
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the mortality experience of 50 000 nurses using the National Occupational Mortality Surveillance database of death certificates. Methods. Proportionate mortality ratios adjusted by race (White, Black, or other) and 5-year age groups were calculated for selected causes of death among female nurses vs all workers and white-collar workers. Results. Excess deaths among nurses less than 65 years of age were seen in both comparison groups for viral hepatitis, cancer of the nasal cavities, accidental falls, suicide, and drug-related deaths. Among nurses 65 years old or older, deaths due to chronic myeloid leukemia were in excess. Proportionate mortality ratios for breast and colon cancers, diabetes, and heart disease varied by occupational comparison group. Conclusions. These findings confirm results of previous studies and identify new associations. Redoubled efforts are called for in overcoming obstacles to reducing workplace hazards. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Mortality
KW - Nurses
KW - Death certificates
KW - Chronic myeloid leukemia
KW - Women
N1 - Accession Number: 9710250218; Peipins, Lucy A. 1; Burnett, Carol 2; Alterman, Toni 2; Lalich, Nina 2; Affiliations: 1: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Ga.; 2: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Sep97, Vol. 87 Issue 9, p1539; Thesaurus Term: DISEASES; Subject Term: Mortality; Subject Term: Nurses; Subject Term: Death certificates; Subject Term: Chronic myeloid leukemia; Subject Term: Women; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3879
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ER -
TY - JOUR
AU - Redd, John T.
AU - Susser, Ezra
T1 - Controlling tuberculosis in an urban emergency department: A rapid decision instrument for patient isolation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/09//
VL - 87
IS - 9
M3 - Article
SP - 1543
EP - 1547
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined whether data routinely available in emergency departments could be used to improve isolation decisions for tuberculosis patients. Methods. In a large emergency department in New York City, we compared the exposure histories of tuberculosis culture-positive and culture-negative patients and used these data to develop a rapid decision instrument to predict culture-positive tuberculosis. The screen used only data that are routinely available to emergency physicians. Results. The method had high sensitivity (.96) and moderate specificity (.54). Conclusions. The method is easily adaptable for a broad range of settings and illustrates the potential benefits of applying basic epidemiologic methods in a clinical setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Isolation (Hospital care)
KW - Tuberculosis patients
KW - Hospital emergency services
KW - New York (N.Y.)
KW - New York (State)
N1 - Accession Number: 9710250219; Redd, John T. 1,2; Susser, Ezra 3; Affiliations: 1: Indian Health Service, Department of Medicine, Northern Navajo Medical Center, Shiprock, NM; 2: Columbia University College of Physicians and Surgeons, New York; 3: Division of Epidemiology and Community Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute/Columbia University New York, NY; Issue Info: Sep97, Vol. 87 Issue 9, p1543; Subject Term: Isolation (Hospital care); Subject Term: Tuberculosis patients; Subject Term: Hospital emergency services; Subject: New York (N.Y.); Subject: New York (State); Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3690
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DB - eih
ER -
TY - JOUR
ID - 107192561
T1 - Systemic allergic reaction following ingestion of undeclared peanut flour in a peanut-sensitive woman.
AU - McKenna C
AU - Klontz KC
Y1 - 1997/09//1997 Sep
N1 - Accession Number: 107192561. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9503580.
KW - Food Hypersensitivity
KW - Nuts
KW - Adult
KW - Female
SP - 234
EP - 236
JO - Annals of Allergy, Asthma & Immunology
JF - Annals of Allergy, Asthma & Immunology
JA - ANN ALLERGY ASTHMA IMMUNOL
VL - 79
IS - 3
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: Although peanuts and peanut butter are well recognized as food allergens, few reports describe allergic reactions associated with eating peanut flour. OBJECTIVE: To describe an allergic reaction that occurred in a peanut-sensitive woman who ate undeclared peanut flour that was part of a flavor ingredient contained in a dry soup mixture, and to estimate the amount of peanut protein the patient ingested. METHODS: The patient was interviewed, medical records from her emergency room visit were reviewed, and the manufacturer of the soup mix was investigated to ascertain the proportion of the soup mix constituted by the undeclared peanut flour. RESULTS: Minutes after ingesting the soup, a 33-year-old woman experienced a systemic allergic reaction. She was treated successfully in the emergency room with intravenous fluids, corticosteroids, and diphenhydramine. Investigation of the soup manufacturer revealed that undeclared peanut flour was a component of a flavoring ingredient in the soup. Based on the concentration of peanut flour in the flavoring, we estimated the patient ate approximately 45 mg of peanut protein. CONCLUSIONS: Inadvertent ingestion of peanut flour by peanut-sensitive individuals may lead to systemic allergic reactions.
SN - 1081-1206
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St, SW, Washington, DC 20204
U2 - PMID: 9305230.
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ER -
TY - JOUR
AU - Bolon, Brad
AU - Bucci, Thomas J.
AU - Warbritton, Alan R.
AU - Chen, James J.
AU - Mattison, Donald R.
AU - Heindel, Jerrold J.
T1 - Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1997/09//
VL - 39
IS - 1
M3 - Article
SP - 1
EP - 10
PB - Oxford University Press / USA
SN - 02720590
AB - Ovaries from National Toxicology Program Reproductive Assessment by Continuous Breeding (RACB) bioassays were used to directly compare differential ovarian follicle counts and reproductive performance for 15 chemicals. Ovaries of 10 animals per group from 16 studies in CD-1 mice and 1 study each in C3H and C57BL/6 mice were sectioned serially at 6 μm. Counts of small, growing, and antral follicles were obtained in every 10th section. For all follicle types, younger mice had more follicles than older mice, and CD-1 mice had more follicles than age-matched animals from either inbred strain. The in-life portion of the RACB protocols demonstrated that 9 of 15 chemicals altered reproductive outcome in one or both sexes of mice, with six agents affecting females (R. E. Morrissey et al., 1989, Furuiam. Appl Toxicol 13, 747–777). Three of six female toxicants [ 2,2-bis(bromoethyl)-1,3-Propanediol, BPD; ethylene glycol monomethyl ether, EGME; methoxyacetic acid, MAA] significantly decreased counts of small and/or growing follicles by 33 to 92% In CD-1 mice; EGME also reduced follicle counts in the other strains. Follicle counts were decreased in progeny of animals treated with EGME or its active metabolite, MAA. For BPD, reductions in follicle numbers were proportional to dose. In CD-1 mice, female toxicants di-N-hexyl phthalate, propantheline bromide, and tricresyl phosphate reduced reproductive performance but not follicle numbers. Counts were not affected by toxicants for which the susceptible sex could not be determined (bisphenol A, ethylene glycol, oxalic acid). Altered follicle counts without apparent reproductive impairment occurred in CD-1 mice at lower doses of BPD but were not observed for nontoxic chemicals. These data suggest that differential follicle counts (1) are a quantifiable endpoint of ovarian injury in conventional bioassays, and (2) in some instances, may provide a more sensitive indicator of female reproductive toxicity than fertility. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological assay
KW - Toxicology
KW - Follicle-stimulating hormone
KW - Mice as laboratory animals
KW - Bromides
N1 - Accession Number: 82413025; Bolon, Brad 1; Bucci, Thomas J. 1; Warbritton, Alan R. 1; Chen, James J. 2; Mattison, Donald R. 2; Heindel, Jerrold J. 3; Affiliations: 1: Pathology Associates International (an SAIC Company) Jefferson, Arkansas 72079; 2: † Biometry and Risk Assessment Division, National Center for Toxicological Research Jefferson, Arkansas 72079; 3: ‡ Developmental and Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709; Issue Info: 1997, Vol. 39 Issue 1, p1; Thesaurus Term: Biological assay; Thesaurus Term: Toxicology; Subject Term: Follicle-stimulating hormone; Subject Term: Mice as laboratory animals; Subject Term: Bromides; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Ore, Timothy
AU - Stout, Nancy A.
T1 - Risk Differences in Fatal Occupational Injuries Among Construction Laborers in the United States, 1980-1992.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/09//
M3 - Article
SP - 832
EP - 843
SN - 00961736
AB - Over 3700 occupational fatalities among all US construction laborers 16 years of age and older during 1980-1992 were analyzed from death certificates to identify differences in mortality rates, higher risk groups, and leading causes of death to be targeted for prevention and monitored over time. Female laborers had an average fatality rate (17.4 deaths/100,000 workers) similar to that for all male construction workers (17.3 deaths/100,000 workers), and ten times higher than for all female construction workers. On average, nonwhite laborers had 27% greater mortality than white laborers. Women were at a higher risk (10.8 deaths/100,000 workers) for motor vehicle injury than were men (6.1 deaths/100,000 workers). The smallest percentage annual decline in cause-specific mortality rates was from motor vehicle for construction laborers (0.1 %) and all construction workers (1.4%). Environmental-related fatality rates for laborers rose an average of 0.8% annually. The average years of potential life lost (to age 65) ranged from 27.4 years from explosion to 34.3 years from electrocution. Prevention measures aimed at addressing the highest risk areas, along with research needs, are discussed. With over a quarter of construction fatalities occurring among laborers, occupational injury research on laborers should become a priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379237; Ore, Timothy 1; Stout, Nancy A. 1; Source Information: Sep1997, p832; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 6863
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DB - hch
ER -
TY - JOUR
AU - Layne, Larry A.
AU - Landen, Deborah D.
T1 - A Descriptive Analysis of Nonfatal Occupational Injuries to Older Workers, Using a National Probability Sample of Hospital Emergency Departments.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/09//
M3 - Article
SP - 855
EP - 865
SN - 00961736
AB - An estimated 136,985 nonfatal, work-related injuries to workers 55 years of age and older were presented for treatment in hospital emergency departments across the United States during 1993. Men accounted for 63.7% of the injuries and had an injury rate of 1.06 per 100 workers, compared with a rate of 0.76 among women. Among the oldest workers (65+ years), injuries were more likely to be fractures or dislocations, to result from falls on the same level, or to involve hospitalization. The services industry had the largest number of injuries (31.9%), whereas the highest injury rate occurred in the agriculture/forestry/fishing industry (1.50 per 100 workers). The types of injuries most frequently requiring hospitalization were fractures or dislocations that resulted from a fall. Because older workers' employment demographics and injury patterns differ from the remainder of the labor force, interventions need to be developed which are specific to the workplace for this older working population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379240; Layne, Larry A. 1; Landen, Deborah D. 1; Source Information: Sep1997, p855; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 7524
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ER -
TY - JOUR
AU - Silliman, Nancy Paul
T1 - Hierarchical Selection Models With Applications in Meta-Analysis.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1997/09//
VL - 92
IS - 439
M3 - Article
SP - 926
EP - 936
SN - 01621459
AB - Hierarchical selection models arc introduced and shown to be useful in meta-analysis. These models combine the use of hierarchical models, allowing investigation of variability both within and between studies, and weight functions, allowing modeling of nonrandomly selected studies. Markov chain Monte Carlo (MCMC) methods are used to estimate the hierarchical selection model. This is first illustrated for known weight functions, and then extended to allow for estimation of unknown weight functions. To investigate sensitivity of results to unobserved studies directly, which is shown to be different from modeling bias in the selection of observed studies, the hierarchical selection model is used in con unction with data augmentation. Again, MCMC methods may be used to estimate the model. This is illustrated for an unknown weight function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL models
KW - SIMULATION methods & models
KW - MARKOV processes
KW - MATHEMATICAL optimization
KW - META-analysis
KW - PSYCHOMETRICS
KW - Data augmentation
KW - Hierarchical model
KW - Monte Carlo
KW - Selection bias
KW - Weight function.
N1 - Accession Number: 9710132397; Silliman, Nancy Paul 1; Affiliations: 1: Mathematical statistician, Division of Biometrics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD.; Issue Info: Sep97, Vol. 92 Issue 439, p926; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: SIMULATION methods & models; Thesaurus Term: MARKOV processes; Thesaurus Term: MATHEMATICAL optimization; Subject Term: META-analysis; Subject Term: PSYCHOMETRICS; Author-Supplied Keyword: Data augmentation; Author-Supplied Keyword: Hierarchical model; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: Selection bias; Author-Supplied Keyword: Weight function.; Number of Pages: 11p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wassell, James T.
T1 - Probability and Information: An Integrated Approach.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 1997/09//
VL - 92
IS - 439
M3 - Book Review
SP - 1225
EP - 1225
SN - 01621459
AB - Reviews the book "Probability and Information: An Integrated Approach," by David Applebaum.
KW - PROBABILITY theory
KW - NONFICTION
KW - APPLEBAUM, David
KW - PROBABILITY & Information: An Integrated Approach (Book)
N1 - Accession Number: 9710132521; Wassell, James T. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention.; Issue Info: Sep97, Vol. 92 Issue 439, p1225; Thesaurus Term: PROBABILITY theory; Subject Term: NONFICTION; Reviews & Products: PROBABILITY & Information: An Integrated Approach (Book); People: APPLEBAUM, David; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Stayner, Leslie
AU - Smith, Randall
AU - Bailer, John
AU - Gilbert, Stephen
AU - Steenland, Kyle
AU - Dement, John
AU - Brown, David
AU - Lemen, Richard
T1 - Exposure-response analysis or risk of respiratory disease associated with occupational exposure to chrysotile asbestos.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 1997/09//
VL - 54
IS - 9
M3 - Article
SP - 646
EP - 652
SN - 13510711
AB - Objectives: To evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos. Methods: Data were used from a recent update of a cohort mortality study of workers in a South Carolina textile factory. Alternative exposure-response models were evaluated with Poisson regression. A model designed to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach that accounts for competing causes of death. Results: A highly significant exposure-response relation was found for both lung cancer and asbestosis. The exposure-response relation for lung cancer seemed to be linear on a multiplicative scale, which is consistent with previous analyses of lung cancer and exposure to asbestos. In contrast, the exposure-response relation for asbestosis seemed to be nonlinear on a multiplicative scale in this analysis. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis. The excess lifetime risk for white men exposed for 45 years at the recently revised OSHA standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer, and 2/1000 for asbestosis. Conclusions: This study confirms the findings from previous investigations of a strong exposure-response relation between exposure to chrysotile asbestos and mortality from lung cancer, and asbestosis. The risk estimates for lung cancer derived from this analysis are higher than those derived from other populations exposed to chrysotile asbestos. Possible reasons for this discrepancy are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Risk assessment
KW - Threshold limit values (Industrial toxicology)
KW - Asbestos -- Health aspects
KW - Lungs -- Cancer -- Patients
KW - chrysotile asbestos
KW - epidemiology
KW - risk assessment
N1 - Accession Number: 8002977; Stayner, Leslie 1; Smith, Randall 1; Bailer, John 1,2; Gilbert, Stephen 1; Steenland, Kyle 1; Dement, John 3; Brown, David 4; Lemen, Richard 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio 45226, USA; 2: Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA; 3: Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA; 4: National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA; Issue Info: Sep1997, Vol. 54 Issue 9, p646; Thesaurus Term: Epidemiology; Thesaurus Term: Risk assessment; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Asbestos -- Health aspects; Subject Term: Lungs -- Cancer -- Patients; Author-Supplied Keyword: chrysotile asbestos; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: risk assessment; Number of Pages: 7p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1136/oem.54.9.646
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107346716
T1 - Palliative medicine and HIV/AIDS.
AU - O'Neill JF
AU - Alexander CS
Y1 - 1997/09//1997 Sep
N1 - Accession Number: 107346716. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - Palliative Care
KW - HIV Infections
KW - Acquired Immunodeficiency Syndrome
KW - HIV-Infected Patients
KW - Pain -- Therapy
KW - Suicide, Assisted
SP - 607
EP - 615
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 24
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0095-4543
AD - AIDS Program Office, Health Resources and Services Administration, US Public Health Service, Rockville
U2 - PMID: 9271695.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107346719
T1 - The clinical management of children perinatally exposed to HIV.
AU - Rodriguez EM
AU - Diaz C
AU - Fowler MG
Y1 - 1997/09//1997 Sep
N1 - Accession Number: 107346719. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - HIV Infections -- In Infancy and Childhood
KW - Acquired Immunodeficiency Syndrome -- In Infancy and Childhood
KW - Disease Transmission, Vertical
KW - Risk Factors
KW - HIV Infections -- Etiology -- In Infancy and Childhood
KW - Zidovudine -- Therapeutic Use -- In Pregnancy
KW - Fetus -- Drug Effects
KW - Disease Progression
KW - Neurologic Manifestations -- In Infancy and Childhood
KW - Patient Care
KW - Antiviral Agents -- Therapeutic Use -- In Infancy and Childhood
KW - Antibiotic Prophylaxis -- In Infancy and Childhood
KW - HIV Infections -- Drug Therapy -- In Infancy and Childhood
KW - Pneumonia, Pneumocystis -- Drug Therapy -- In Infancy and Childhood
KW - Fetus
KW - Infant, Newborn
KW - Pregnancy
KW - Female
SP - 643
EP - 666
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 24
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0095-4543
AD - Bureau for Health Resources and Development, Health Resources and Services Administration, Rockville, Maryland
U2 - PMID: 9271697.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107346721
T1 - Primary care of the HIV-seropositive chemically dependent patient.
AU - O'Neill JF
Y1 - 1997/09//1997 Sep
N1 - Accession Number: 107346721. Language: English. Entry Date: 19971101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - HIV Infections
KW - Substance Abusers
KW - Substance Abuse -- Complications
KW - Substance Abuse -- Therapy
KW - HIV Infections -- Therapy
SP - 667
EP - 676
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 24
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0095-4543
AD - HIV/AIDS Bureau, Health Resources and Services Administration, US Public Health Service, Rockville
U2 - PMID: 9271698.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107160083
T1 - Profile of raw milk consumers in California.
AU - Headrick ML
AU - Timbo B
AU - Klontz KC
AU - Werner SB
Y1 - 1997/09//Sep/Oct97
N1 - Accession Number: 107160083. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Milk -- Utilization
KW - Consumers
KW - Food Habits
KW - Epidemiological Research
KW - Descriptive Research
KW - Prevalence
KW - Surveys
KW - Self Report
KW - Telephone
KW - Random Sample
KW - Descriptive Statistics
KW - P-Value
KW - Food Contamination
KW - Risk Taking Behavior
KW - Hispanics
KW - Age Factors
KW - Sex Factors
KW - Socioeconomic Factors
KW - Educational Status
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 418
EP - 422
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 112
IS - 5
PB - Sage Publications Inc.
AB - Objectives. The authors sought to deter-mine the prevalence of raw milk consumption in California--the largest producer of certified raw milk in the United States-and to describe the demographic and behavioral characteristics of raw milk consumers in that state. Methods. The authors analyzed responses to questions on the 1994 California Behavioral Risk Factor Surveillance System Survey that asked respondents about whether they drank raw milk, the amount consumed, the reason for drinking raw milk, and where raw milk was most often obtained. Results. Among 3999 survey respondents, 3.2% reported drinking raw milk in the previous year, Raw milk drinkers were more likely than nondrinkers to be younger than age 40, male, and Hispanic and to have less than a high school education. Conclusions. Raw milk continues to be consumed by some residents of California despite the documented hazards associated with this dietary practice.
SN - 0033-3549
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC
U2 - PMID: 9323394.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107172476
T1 - Hearing loss from combined exposures among petroleum refinery workers.
AU - Morata TC
AU - Engel T
AU - Durao A
AU - Costa TRS
AU - Krieg EF
AU - Dunn DE
AU - Lozano MA
Y1 - 1997/09//
N1 - Accession Number: 107172476. Language: English. Entry Date: 19990301. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Continental Europe; Europe; Peer Reviewed. Grant Information: ECOPETROL, PAHO, the Ministry of Health of Colombia and the United States National Institute for Occupational Safety and Health. NLM UID: 0342230.
KW - Hearing Loss, Noise-Induced
KW - Occupational Exposure
KW - Funding Source
KW - Comparative Studies
KW - South America
KW - Industry
KW - Solvents
KW - Male
KW - Audiometry, Pure-Tone
KW - Questionnaires
KW - Acoustic Impedance Tests
KW - Analysis of Variance
KW - Univariate Statistics
KW - Fisher's Exact Test
KW - Logistic Regression
KW - Multivariate Analysis of Variance
KW - Human
SP - 141
EP - 149
JO - Scandinavian Audiology
JF - Scandinavian Audiology
JA - SCAND AUDIOL
VL - 26
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Workers from a refinery (n = 438) were interviewed, had their hearing tested and had their exposures to noise and solvents assessed. Measurements suggested that most exposures to noise and solvents were within exposure limits recommended by international agencies; however, the prevalence for hearing loss within the exposed groups ranged from 42 to 50%, significantly exceeding the 15-30% prevalence observed for unexposed groups. The adjusted odds ratio estimates for hearing loss were 2.4 times greater for groups from aromatics and paraffins (95% CI 1.0-5.7), 3 times greater for the maintenance group (95% CI 1.3-6.9) and 1.8 times greater for the group from shipping (95% CI 0.6-4.9), when compared to unexposed workers from the warehouse and health clinic. The results of acoustic reflex decay tests suggest a retrocochlear or central auditory pathway involvement in the losses observed in certain job categories. These findings indicate that factors in addition to noise ought to be considered when investigating and preventing occupational hearing loss.
SN - 0105-0397
AD - National Institute for Occupational Safety and Health, Biacoustics and Occupational Vibration Section, Division of Biomedical and Behavioral Science, Cincinnati, Ohio. E-mail: thais.morata@niwl.se
U2 - PMID: 9309809.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105819637
T1 - Home collection and non-blood-based methods of testing for the human immunodeficiency virus.
AU - Goetsch R
AU - Minor JR
AU - Piscitelli SC
Y1 - 1997/10//1997 Oct 1
N1 - Accession Number: 105819637. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Antigens, Viral -- Analysis
KW - HIV Infections -- Diagnosis
KW - Human Immunodeficiency Virus -- Immunology
KW - Reagent Kits, Diagnostic
KW - Antigens, Viral -- Urine
KW - Blotting, Western
KW - Enzyme-Linked Immunosorbent Assay
KW - HIV Infections -- Immunology
KW - HIV Infections -- Urine
KW - Saliva
SP - 2232
EP - 2235
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 54
IS - 19
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Division of Pharmacovigilance and Epidemiology, Food and Drug Administration, Rockville, MD, USA.
U2 - PMID: 9331447.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Todd, Joan Ferlo
AU - Ruhl, Constance E.
AU - Gross, Thomas P.
T1 - Injury and death associated with hospital bed side-rails: Reports to the US Food and Drug Administration from 1985 to 1995.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/10//
VL - 87
IS - 10
M3 - Article
SP - 1675
EP - 1675
PB - American Public Health Association
SN - 00900036
AB - Objectives. Hospital bed side-rails, while intended for patient protection, can contribute to injury and death. Reports to the Food and Drug Administration (FDA) of hospital bed side-rail entrapment have increased. In this paper entrapment cases are reviewed and the population potentially at risk identified. Methods. FDA's database was searched for events involving hospital beds from January 1985 to August 1995 and entrapment cases were identified. Results. Of 111 entrapments, 65% were associated with death and 23% with injury. Conclusions. Advanced age, female sex, low body weight, and cognitive impairment may be associated with increased risk. Preventive measures are detailed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Wounds & injuries
KW - Health risk assessment
KW - Hospital beds
KW - Hospital patients
KW - Death
KW - Hospitals -- Furniture, equipment, etc.
KW - United States. Food & Drug Administration
N1 - Accession Number: 9711170417; Todd, Joan Ferlo 1; Ruhl, Constance E. 1; Gross, Thomas P. 1; Affiliations: 1: Center for Radiological Devices and Health, US Food and Drug Administration, Rockville, Md.; Issue Info: Oct97, Vol. 87 Issue 10, p1675; Thesaurus Term: Wounds & injuries; Thesaurus Term: Health risk assessment; Subject Term: Hospital beds; Subject Term: Hospital patients; Subject Term: Death; Subject Term: Hospitals -- Furniture, equipment, etc. ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 1540
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107349067
T1 - Device errors. Heating devices: how to avoid burns.
AU - Todd JF
Y1 - 1997/10//
N1 - Accession Number: 107349067. Language: English. Entry Date: 19971201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Burns -- Prevention and Control
KW - Equipment Safety
KW - Heat-Cold Application -- Adverse Effects
SP - 83
EP - 83
JO - Nursing
JF - Nursing
JA - NURSING
VL - 27
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD
U2 - PMID: 9355519.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107251636
T1 - Comparison of actual and recommended ENT endoscope disinfection practices, by geographical regions in the United States.
AU - Baker K
AU - McCullagh L
Y1 - 1997///1997 Fall
N1 - Accession Number: 107251636. Language: English. Entry Date: 19980401. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9206573.
KW - Endoscopes
KW - Sterilization and Disinfection
KW - United States
KW - Comparative Studies
KW - Otorhinolaryngology and Head-Neck Nursing
KW - Random Sample
KW - Surveys
KW - Demography
KW - AORN -- Standards
KW - Sterilization and Disinfection -- Standards
KW - Disinfectants
KW - Human
SP - 14
EP - 17
JO - ORL-Head & Neck Nursing
JF - ORL-Head & Neck Nursing
JA - ORL HEAD NECK NURS
VL - 15
IS - 4
CY - New Smyrna Beach, Florida
PB - Society of Otorhinolaryngology & Head-Neck Nurses
AB - Endoscopy of the aerodigestive tract, a commonly performed procedure in ENT practice, is not without risk of disease transmission. Review of the nursing literature reveals concern regarding endoscopy of the GI tract, but little has been published regarding disease transmission from ENT endoscopy. The ENT nursing literature does not offer specific practice guidelines for high level disinfection (HLD) of ENT endoscopes. This lack of practice guidelines and recognized confusion regarding clinical practice led to the need for a national survey of ENT nurses to examine what reprocessing practices are being performed. Questionnaires were sent to 150 nurse members of the Society of Otorhinolaryngology-Head and Neck Nurses (SOHN) to gather information about actual endoscope cleaning practices and whether there were any regional differences. Eighty completed forms were returned. The results were tabulated and compared to the AORN recommended method of achieving HLD by glutaraldehyde soak. Results indicate SOHN nurses use a variety of methods to clean and disinfect endoscopes; some nurses use methods not recommended for HLD; results do not demonstrate a universal understanding of the requirements to achieve HLD; regional differences were not obvious; and SOHN nurses may benefit from use of a professionally endorsed disinfection protocol.
SN - 1064-3842
AD - Nurse Consultant, ENT Devices Branch, Office of Device Evaluation, Food and Drug Administration
U2 - PMID: 9429508.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Canady, Richard A.
AU - Hanley, Jack E.
AU - Susten, Allan S.
T1 - ATSDR Science Panel on the Bioavailability of Mercury in Soils: Lessons Learned.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1997/10//
VL - 17
IS - 5
M3 - Article
SP - 527
EP - 532
SN - 02724332
AB - On the basis of discussion and analysis during and following an ATSDR science panel on the bioavailability of mercury in soils, it is apparent that the default assumption of 100% relative bioavailability for mercury-contaminated soils is excessively conservative. However, current knowledge does not allow the development of default assumptionsor guidelines for determining relative bioavailability of mercury insoils. Until such default assumptions or guidelines can be developed, site-specific assays of bioavailability, preferably using either animal bioassays or validated in vitro techniques, may provide the bestapproach for estimating soil-mercury bioavailability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mercury in soils
KW - Bioavailability
KW - Soil testing
KW - Soil composition
KW - Soil pollution
KW - Biochemistry
KW - Animal bioassay
KW - ATSDR.
KW - Mercury
KW - Risk assessment
KW - Science panel
KW - Soil contamination
KW - soil ingestion
KW - Soil science
KW - Toxic substanceexposure
N1 - Accession Number: 8114865; Canady, Richard A. 1; Hanley, Jack E. 1; Susten, Allan S. 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia.; Issue Info: Oct97, Vol. 17 Issue 5, p527; Thesaurus Term: Mercury in soils; Thesaurus Term: Bioavailability; Thesaurus Term: Soil testing; Thesaurus Term: Soil composition; Thesaurus Term: Soil pollution; Subject Term: Biochemistry; Author-Supplied Keyword: Animal bioassay; Author-Supplied Keyword: ATSDR.; Author-Supplied Keyword: Mercury; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Science panel; Author-Supplied Keyword: Soil contamination; Author-Supplied Keyword: soil ingestion; Author-Supplied Keyword: Soil science; Author-Supplied Keyword: Toxic substanceexposure; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zheng, Qi
T1 - A Unified Approach to a Class of Stochastic Carcinogenesis Models.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1997/10//
VL - 17
IS - 5
M3 - Article
SP - 617
EP - 624
SN - 02724332
AB - Survival and hazard functions play a pivotal role in carcinogenesis modeling. This paper provides a unified approach to computing these two quantities by classifying a large class of carcinogenesis models from a computational point of view, and prescribes specific computational recipes according to this classification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Carcinogenicity
KW - Mathematical models
KW - Cancer research
KW - Stochastic processes
KW - Mathematical analysis
KW - Differential equasion
KW - differential equation.
KW - hazard function
KW - Mathematical model
KW - Risk assessment
KW - Stochastic carcinogenesis model
KW - Survival function
N1 - Accession Number: 8114864; Zheng, Qi 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079.; Issue Info: Oct97, Vol. 17 Issue 5, p617; Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogenicity; Thesaurus Term: Mathematical models; Subject Term: Cancer research; Subject Term: Stochastic processes; Subject Term: Mathematical analysis; Author-Supplied Keyword: Differential equasion; Author-Supplied Keyword: differential equation.; Author-Supplied Keyword: hazard function; Author-Supplied Keyword: Mathematical model; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Stochastic carcinogenesis model; Author-Supplied Keyword: Survival function; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105824693
T1 - Liquid cold storage of platelets: a revitalized possible alternative for limiting bacterial contamination of platelet products.
AU - Vostal JG
AU - Mondoro TH
Y1 - 1997/10//1997 Oct
N1 - Accession Number: 105824693. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8709027.
KW - Blood Platelets -- Microbiology
KW - Blood Preservation -- Methods
KW - Cryopreservation -- Methods
KW - Animals
KW - Blood Component Transfusion
KW - Drug Contamination
KW - Platelet Activation
SP - 286
EP - 295
JO - Transfusion Medicine Reviews
JF - Transfusion Medicine Reviews
JA - TRANSFUS MED REV
VL - 11
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0887-7963
AD - Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
U2 - PMID: 9345710.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1997-05609-011
AN - 1997-05609-011
AU - Athey, Jean L.
AU - O'Malley, Patricia
AU - Henderson, Deborah P.
AU - Ball, Jane W.
T1 - Emergency medical services for children: Beyond lights and sirens.
JF - Professional Psychology: Research and Practice
JO - Professional Psychology: Research and Practice
JA - Prof Psychol Res Pr
Y1 - 1997/10//
VL - 28
IS - 5
SP - 464
EP - 470
CY - US
PB - American Psychological Association
SN - 0735-7028
SN - 1939-1323
N1 - Accession Number: 1997-05609-011. Other Journal Title: Professional Psychology. Partial author list: First Author & Affiliation: Athey, Jean L.; US Public Health Service, Dept of Health & Human Services, Medical Services for Children Program, Rockville, MD, US. Release Date: 19980401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emergency Services; Medical Treatment (General); Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 7. Issue Publication Date: Oct, 1997. Publication History: Accepted Date: Apr 30, 1997; Revised Date: Dec 18, 1996; First Submitted Date: Jan 31, 1996. Copyright Statement: Public Domain
AB - This article describes the history of emergency medical services for children and identifies important mental health issues. It discusses the roles of psychologists in such services, including intervening with children and their families during times of crisis, helping others who are providing the physical care of children to mitigate rather than exacerbate children's emotional distress, and attending to the emotional needs of health care providers who treat children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health treatment issues in emergency medical services
KW - children
KW - 1997
KW - Emergency Services
KW - Medical Treatment (General)
KW - Mental Health Services
KW - 1997
DO - 10.1037/0735-7028.28.5.464
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1997-05609-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - LaBorde, James B.
AU - Terry, Ketti K.
AU - Howard, Paul C.
AU - Chen, James J.
AU - Collins, Thomas F. X.
AU - Shackelford, Mary E.
AU - Hansen, Deborah K.
T1 - Lack of Embryotoxicity of Fumonisin B1 in New Zealand White Rabbits.
JO - Fundamental & Applied Toxicology
JF - Fundamental & Applied Toxicology
Y1 - 1997/11//
VL - 40
IS - 1
M3 - Article
SP - 120
EP - 128
PB - Oxford University Press / USA
SN - 02720590
AB - Fumonisin B (FB1) is one of a number of mycotoxins produced by fungi, especially Fusarium sp. As a contaminant of many maizederived products, this toxin is associated with a variety of animal diseases, including esophageal cancer and possibly neural tube defects in humans. We have investigated the embryotoxic potential of this compound in New Zealand White rabbits. Animals were dosed by gavage daily on GD 3–19 with purilied FB1 at 0.10, 0.50, or 1.00 mg/kg/day. Maternal lethality occurred at the 0.50 and 1.00 mg/kg/day doses. When examined on GD 29, there were no differences in maternal body weight, maternal weight gain, maternal organ weights, number of nonlive iinplantations, and number of malformations. Fetal weight was decreased at 0.50 and 1.00 mg/kg/day (13 and 16%, respectively); this was true for male and female pups. Fetal liver and kidney weights were also decreased at these doses. Analysis of embryonic sphinganine to sphingosine ratios demonstrated no differences between control and treated embryos on GD 20, although these ratios were increased in maternal urine, serum, and kidney when compared to control animals. These data suggest that FB1 did not cross the placenta and that the observed decreased fetal weight was probably the result of maternal toxicity, rather than any developmental toxicity produced by FB1. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Fundamental & Applied Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 82502625; LaBorde, James B. 1; Terry, Ketti K. 1; Howard, Paul C. 2; Chen, James J. 3; Collins, Thomas F. X. 4; Shackelford, Mary E. 4; Hansen, Deborah K. 1; Affiliations: 1: Division of Reproductive and Developmental Toxicology Jefferson, Arkansas 72079-9502; 2: † Division of Biochemical Toxicology Jefferson, Arkansas 72079-9502; 3: ‡ Division of Biometry and Risk Assessment National Center for Toxicological Research, Food and Drug Administration, Department of Health and Human Services Jefferson, Arkansas 72079-9502; 4: § Center for Food Safety and Applied Nutrition 8301 Muirkirk Road, HFS-507, Food and Drug Administration, Laurel, Maryland 20708; Issue Info: 1997, Vol. 40 Issue 1, p120; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107243586
T1 - Pre-eruptive intracoronal lesion of a mandibular first molar.
AU - Kunz GT
Y1 - 1997/11//1997 Nov-Dec
N1 - Accession Number: 107243586. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7610466.
KW - Tooth Abnormalities -- Diagnosis
KW - Molar
KW - Female
KW - Child
KW - Endodontics
SP - 574
EP - 579
JO - General Dentistry
JF - General Dentistry
JA - GEN DENT
VL - 45
IS - 6
CY - Chicago, Illinois
PB - Academy of General Dentistry
SN - 0363-6771
AD - Tucson Area Indian Health Service, Tuscon, Arizona
U2 - PMID: 9663086.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107243586&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107238154
T1 - Human error and patient-controlled analgesia pumps.
AU - Brown SL
AU - Bogner MS
AU - Parmentier CM
AU - Taylor JB
Y1 - 1997/11//1997 Nov-Dec
N1 - Accession Number: 107238154. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8804311.
KW - Infusion Pumps -- Adverse Effects
KW - Patient-Controlled Analgesia -- Equipment and Supplies
KW - Medication Errors
KW - Equipment Design
KW - Product Labeling
KW - United States Food and Drug Administration
KW - Mandatory Reporting
KW - Overdose -- Etiology
KW - Equipment Safety
KW - Equipment Failure
SP - 311
EP - 316
JO - Journal of Intravenous Nursing
JF - Journal of Intravenous Nursing
JA - J INTRAVENOUS NURS
VL - 20
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Contrary to the prevailing attitude that error is a source of blame and punishment, errors can be an opportunity to discover a problem and institute activities to correct the problem to reduce the likelihood of recurrence. Often the source of error may be the system in which it occurred, not the person associated with it. Error in any domain, including healthcare, is difficult to identify and address because persons are reluctant to report errors for fear of self-incrimination. The discipline of human factors addresses issues related to human performance including use error. Human factors analysis provides insight into the etiology of use errors and how they can be reduced. Patient-controlled analgesia (PCA) pumps were developed to allow the patient or care-giver more control over pain relief. The PCA pumps can be programmed to deliver pain medication on a continuous basis, intermittently, or as a bolus. Selected adverse incidents involving PCA pumps that were due to use error and reported to the U.S. Food and Drug Administration are described. Finally, implications of those findings and the potential for reducing use error by applying considerations of the discipline of human factors are discussed.
SN - 0896-5846
AD - Senior Research Scientist Officer, Center for Devices and Radiological Health
U2 - PMID: 9423393.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107238154&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Abrons, Henry L.
AU - Petersen, Martin R.
AU - Sanderson, Wayne T.
AU - Engelberg, Alan L.
AU - Harber, Philip
T1 - Chest Radiography in Portland Cement Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/11//
M3 - Article
SP - 1047
EP - 1054
SN - 00961736
AB - To investigate the prevalence of pneumoconiosis in Portland cement workers, a controlled cross-sectional survey was conducted. Chest radiographs of approximately 2640 Portland cement workers showed prevalence rates of about 1 to for rounded and for irregular small opacities and about 2% for pleural abnormalities. After age and smoking adjustment, the overall prevalences were still significantly elevated over controls, but when examined separately by smoking status, the significant increases were confined to smokers. Although statistically significant, the prevalences were only elevated about 1% in cement workers, compared with controls. A statistically significant relationship with exposure was found for pleural abnormalities but not for rounded or irregular small opacities. Thus a weak association exists between pulmonary radiographic abnormalities and employment in US Portland cement plants, and there appears to be a dose-response relationship between exposure and pleural abnormalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113380066; Abrons, Henry L. 1; Petersen, Martin R. 1; Sanderson, Wayne T. 1; Engelberg, Alan L. 1; Harber, Philip 1; Source Information: Nov1997, p1047; Number of Pages: 8p; Document Type: Article; Full Text Word Count: 5015
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107254467
T1 - A creative approach to documenting patient education.
AU - Begay TLR
Y1 - 1997/11//
N1 - Accession Number: 107254467. Language: English. Entry Date: 19980401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0225602.
KW - Patient Education
KW - Technology, Medical
KW - Documentation
KW - Clinical Laboratories, Hospital -- Administration
SP - 34
EP - 38
JO - MLO: Medical Laboratory Observer
JF - MLO: Medical Laboratory Observer
JA - MLO
VL - 29
IS - 11
CY - Sarasota, Florida
PB - NP Communications, LLC
AB - Learn how one imaginative medical technologist met the challenge of documenting patient education efforts for JCAHO accreditation by providing patients with important information along with a few laughs.
SN - 0580-7247
AD - Medical Technologist, U.S. Public Health Service, Navaho Area Indian Health Service, Fort Defiance Service Unit, Fort Defiance, Nev
U2 - PMID: 10174096.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107254467&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107234489
T1 - Device errors. Removing catheters: managing freezes and fractures.
AU - Blum D
Y1 - 1997/11//
N1 - Accession Number: 107234489. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Catheters, Vascular -- Adverse Effects
KW - Catheter Removal -- Nursing
KW - Equipment Failure
SP - 32
EP - 32
JO - Nursing
JF - Nursing
JA - NURSING
VL - 27
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Managing freezes and fractures.
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 9397825.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107234489&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107266473
T1 - Rupture of silicone-gel breast implants: causes, sequelae, and diagnosis.
AU - Brown SL
AU - Silverman BG
AU - Berg WA
Y1 - 1997/11/22/
N1 - Accession Number: 107266473. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; pictorial; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Breast Implants
KW - Silicones
KW - Prosthesis Failure
KW - Breast Implants -- Adverse Effects
KW - Diagnostic Imaging
SP - 1531
EP - 1537
JO - Lancet
JF - Lancet
JA - LANCET
VL - 350 North American Edition
IS - 9090
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, US Food and Drug Administration, 1350 Piccard Dr., HFZ-541, Rockville, MD 20850
U2 - PMID: 9388410.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266473&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Levine, A. Joan
AU - Sieber, Karl
AU - Schulte, Paul
AU - Aziz, Dave
T1 - Incidence of Tuberculosis Infection among New York State Prison Employees.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/12//
VL - 87
IS - 12
M3 - Article
SP - 2012
EP - 2014
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined tuberculosis skin test conversions among 24 487 New York State prison employees in 1992. Methods. Conversions were analyzed by prison and by job category. Results. The conversion rate was 1.9%. Employees in prisons with low and high numbers of prisoner cases had odds ratios for conversion of 1.67 (95% confidence interval [CI] = 1.27, 2.19) and 2.20 (95% CI = 1.69, 2.87), respectively, relative to employees in prisons with no prisoner cases. In prisons with cases, guards and medical personnel had odds ratios of 1.64 (95% CI = 1.11, 2.43) and 2.39 (95% CI = 1.40, 4.08), respectively, relative to employees with little prisoner contact. Conclusions. In 1992, approximately one third of new infections among New York State prison employees were due to occupational exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Epidemics
KW - Public health
KW - Prisons -- Officials & employees
KW - New York (State)
N1 - Accession Number: 66038; Steenland, Kyle 1; Levine, A. Joan 2; Sieber, Karl 1; Schulte, Paul 1; Aziz, Dave 3; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: University of Southern California School of Medicine, Los Angeles; 3: New York State Department of Correctional Services, Albany; Issue Info: Dec1997, Vol. 87 Issue 12, p2012; Thesaurus Term: Tuberculosis; Thesaurus Term: Epidemics; Thesaurus Term: Public health; Subject Term: Prisons -- Officials & employees; Subject: New York (State); NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 1766
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Clarke, M. B.;
T1 - Accountability in pharmacy care
CT - Accountability in pharmacy care
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1997/12/01/
VL - 32
IS - Dec
SP - PI
EP - 34
AD - United States Department of Health and Human Services, OIG, 330 Independence Avenue, Southwest, Washington, DC 20201, USA Internet: mclarke@os.dhhs.gov
N1 - Accession Number: 34-12250; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Sociology, Economics and Ethics
N2 - The importance of increasing accountability for the delivery of pharmaceutical care is discussed. A recent government survey of HMOs indicated that managed care organizations conduct minimal oversight of pharmaceutical benefit management companies with which they have contracted. Payers, including the Medicare and Medicaid programs, will need to pay increased attention to overseeing performance to ensure quality services. There is a continued need to develop a framework of standards and measures that can be used to assess the quality of pharmacy services and programs. Learning objectives: 1. Describe two issues raised by Federal agencies concerning quality and accountability in pharmacy care. 2. List the major concern identified by HMOs in working with pharmacy benefit management companies. 3. Describe current efforts by the pharmacy profession and accreditation organizations for measuring and assessing the quality of pharmacy services. Self-assessment questions: True or False: 1. Federal agencies have expressed concern over bias and conflict of interest due to business relationships between pharmacy benefit management companies and pharmaceutical manufacturers. 2. HMOs are most concerned about the adequacy of their own oversight. 3. Private accreditation standards currently provide adequate measurement of quality in pharmacy programs. Answers: 1. T; 2. F; 3. F.
KW - ASHP meeting abstracts--Medicaid, Medicare;
KW - Economics--Medicare--pharmacy benefits;
KW - Economics--Medicaid--pharmacy benefits;
KW - Pharmacy, institutional--reimbursement--Medicaid, Medicare;
KW - Costs--pharmacy services--reimbursement;
KW - Administration--pharmacy services--reimbursement;
KW - Reimbursement--pharmacy services--Medicaid, Medicare;
KW - Pharmacy services--reimbursement--Medicaid, Medicare;
KW - Health benefit programs--Medicare--pharmacy benefits;
KW - Health benefit programs--Medicaid--pharmacy benefits;
KW - Health maintenance organizations--pharmacy services--Medicaid, Medicare;
KW - Quality assurance--pharmacy services--Medicaid, Medicare;
KW - Pharmacy benefit management companies--services--Medicaid, Medicare;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12250&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - McGinnis, T. J.;
T1 - Alternative medicines, the demand, the law and research
CT - Alternative medicines, the demand, the law and research
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1997/12/01/
VL - 32
IS - Dec
SP - PI
EP - -5
AD - Food and Drug Administration, 5600 Fishers Lane, Room 15A-08, Rockville, MD 20857, USA
N1 - Accession Number: 34-12744; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics; Legislation, Laws and Regulations
N2 - No abstract available.
KW - ASHP meeting abstracts--alternative medicine;
KW - Alternative medicine--laws--research;
KW - Laws--alternative medicine;
KW - Research--alternative medicine;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=34-12744&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Frazier, B. M.;
T1 - Preparing for a Food and Drug Administration audit
CT - Preparing for a Food and Drug Administration audit
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1997/12/01/
VL - 32
IS - Dec
SP - PI
EP - 38
AD - Food and Drug Administration, P.O. Box 25730, Raleigh, NC 27611, USA
N1 - Accession Number: 34-12738; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Legislation, Laws and Regulations; Institutional Pharmacy Practice
N2 - This case study will describe federal regulations that influence the procurement and dispensation of pharmaceuticals used in clinical research and how these regulations are incorporated into a Food and Drug Administration (FDA) audit. As clinical research involving pharmaceuticals expands, it is imperative that pharmacists understand and follow FDA Good Clinical Practices. Learning objectives: 1. Describe the mission of the Bioresearch Monitoring Program. 2. Describe the federal regulations that influence the procurement and dispensation of pharmaceuticals used in clinical research. 3. Describe the required record keeping for clinical investigations. Self-assessment questions: True or False: 1. Drug accountability records and records of receipt and disposition of test articles must be retained for at least 2 years after the date of termination or discontinuance of the relevant IND, or at least 2 years after the date of approval of the relevant new drug application. 2. It is a federal regulation that the pharmacy department obtain a copy of the signed informed consent prior to dispensing. 3. When the test article is distributed from the pharmacy department, the investigator is not responsible at all for ensuring that adequate records are maintained. Answers: 1. T; 2. F; 3. F.
KW - Management Case Studies--meeting presentations;
KW - ASHP meeting abstracts--FDA audits;
KW - Clinical studies--drugs, investigational--FDA audits;
KW - Drugs, investigational--clinical studies--FDA audits;
KW - Pharmacy services--drugs, investigational--FDA audits;
KW - Administration--hospital pharmacy--FDA audits;
KW - Pharmacy, institutional, hospital--administration--FDA audits;
KW - Audits--Food and Drug Administration--hospital pharmacy;
KW - Food and Drug Administration (U.S.)--audits--hospital pharmacy;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107209098
T1 - Occupational injury deaths of 16 and 17 year olds in the US: trends and comparisons with older workers.
AU - Castillo DN
AU - Malit BD
Y1 - 1997/12//
N1 - Accession Number: 107209098. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Occupational-Related Injuries -- Mortality -- In Adolescence
KW - Occupational-Related Injuries -- Mortality -- United States
KW - Adult
KW - United States
KW - Comparative Studies
KW - Epidemiological Research
KW - Secondary Analysis
KW - Occupational-Related Injuries -- Mortality -- In Adulthood
KW - Accidents, Occupational -- Prevention and Control
KW - Adolescence
KW - Male
KW - Female
KW - Human
SP - 277
EP - 281
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 3
IS - 4
PB - BMJ Publishing Group
AB - OBJECTIVE: To examine patterns of occupational injury deaths of 16 and 17 year olds in the United States for the three year period 1990-2, examine trends since the 1980s, and compare fatality rates with those of older workers. METHODS: Occupational injury deaths were analyzed using the death certificate based National Traumatic Occupational Fatalities (NTOF) surveillance system. Fatality rates were calculated using estimates of full time equivalent (FTE) workers based on data from the Current Population Survey, a monthly household survey. RESULTS: There were 111 deaths of 16 and 17 year olds for the years 1990-2. The average yearly rate was 3.5 deaths/100,000 FTE. The leading causes of death were motor vehicle related, homicide, and machinery related. All causes occupational injury fatality rates for 16 and 17 year olds were lower than for adults for 1990-2. Rates for the leading causes of death (motor vehicle related, homicide, and machinery related) were comparable or slightly higher than the rates for young and middle aged adult workers. Although rates decreased dramatically from 1980 to 1983, the decreasing trend attenuated in later years. CONCLUSIONS: Comparisons of youth fatality rates to those of adult workers should address differences in patterns of employment, most importantly hours of work. Comparisons to narrow age groupings of adults is preferable to a single category of all workers 18 years and older. Increasing compliance with federal child labor regulations could help reduce work related deaths of youth. Other measures are needed, however, as there are many work hazards, including those associated with homicides, that are not addressed by United States federal child labor law regulations.
SN - 1353-8047
AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS P-180, Morgantown, WV 26505
U2 - PMID: 9493624.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107209098&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tubbs, Randy L.
T1 - Medical Surveillance of HAZMAT Response Fire Figthers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/12//
M3 - Article
SP - 1135
EP - 1135
SN - 00961736
N1 - Accession Number: 113380038; Tubbs, Randy L. 1; Source Information: Dec1997, p1135; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 400
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107241199
T1 - Prevention of sexual intercourse for teen women aged 12 to 14.
AU - Postrado LT
AU - Weiss FL
AU - Nicholson HJ
Y1 - 1997///1997 Winter
N1 - Accession Number: 107241199. Language: English. Entry Date: 19980201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 9710452.
KW - Coitus -- In Adolescence
KW - Adolescence
KW - Pregnancy
KW - Female
SP - 10
EP - 12
JO - Prevention Researcher
JF - Prevention Researcher
JA - PREV RESEARCHER
VL - 4
IS - 1
CY - Eugene, Oregon
PB - Prevention Researcher
SN - 1086-4385
AD - Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, Baltimore
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bailer, A. J.
AU - Stayner, L. T.
AU - Smith, R. J.
AU - Kuempel, E. D.
AU - Prince, M. M.
T1 - Estimating Benchmark Concentrations and Other Noncancer Endpoints in Epidemiology Studies.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1997/12//
VL - 17
IS - 6
M3 - Article
SP - 771
EP - 780
SN - 02724332
AB - Methods for evaluating the hazards associated with noncancer responses with epidemiologic data are considered. The methods for noncancer risk assessment have largely been developed for experimental data, and are not always suitable for the more complex structure of epidemiologic data. In epidemiology, the measurement of the response and the exposure is often either continuous or dichotomous. For a continuous noncancer response modeled with multiple regression, a variety of endpoints may be examined: (1) the concentration associated with absoluteor relative decrements in response; (2) a threshold concentration associated with no change in response; and (3) the concentration associated with a particular added risk of impairment. For a dichotomous noncancer response modeled with logistic regression, concentrations associated with specified added/extra risk or with a threshold responsesmay be estimated. No-observed-effect concentrations may also be estimated for categorizations of exposures for both continuous and dichotomous responses but these may depend on the arbitrary categories chosen. Respiratory function in miners exposed to coal dust is used to illustrate these methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology -- Research
KW - Risk assessment
KW - EPIDEMIOLOGY
KW - HEALTH
KW - Cancer
KW - Cancer -- Risk factors
KW - Miners
KW - Respiratory diseases
KW - added risk
KW - Benchmark concentration
KW - Disease control
KW - Epidemiology
KW - FEV1.
KW - logistic regression
KW - Multiple regression
KW - Noncancer endpoint
KW - Threshold
N1 - Accession Number: 8114881; Bailer, A. J. 1,2; Stayner, L. T. 2; Smith, R. J. 2; Kuempel, E. D. 2; Prince, M. M. 2; Affiliations: 1: Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056-1641; 2: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226; Issue Info: Dec97, Vol. 17 Issue 6, p771; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: Risk assessment; Thesaurus Term: EPIDEMIOLOGY; Thesaurus Term: HEALTH; Subject Term: Cancer; Subject Term: Cancer -- Risk factors; Subject Term: Miners; Subject Term: Respiratory diseases; Author-Supplied Keyword: added risk; Author-Supplied Keyword: Benchmark concentration; Author-Supplied Keyword: Disease control; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: FEV1.; Author-Supplied Keyword: logistic regression; Author-Supplied Keyword: Multiple regression; Author-Supplied Keyword: Noncancer endpoint; Author-Supplied Keyword: Threshold; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schnare, Sharon
AU - Matsuda, Karen J.
AU - Moore, Amy Slugg
T1 - Today's contraceptive choices.
JO - RN
JF - RN
Y1 - 1997/12//
VL - 60
IS - 12
M3 - Article
SP - 30
EP - 101
SN - 00337021
AB - Presents information on contraceptive choices for the 1990s, and how their should be introduced to patients. How to introduce contraceptives to teenagers; Topics to cover with your patient when discussing contraceptives; Detailed information on the contraceptive choices; Advantages and disadvantages of various contraceptives.
KW - CONTRACEPTIVES
N1 - Accession Number: 9712192717; Schnare, Sharon 1; Matsuda, Karen J. 2; Moore, Amy Slugg; Source Information: Dec97, Vol. 60 Issue 12, p30; Subject: CONTRACEPTIVES; Number of Pages: 9p; Illustrations: 2 Color Photographs, 1 Chart; Document Type: Article; Full Text Word Count: 4182
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hasse, Seth
AU - Austin, Michael J.
T1 - Service Integration.
JO - Administration in Social Work
JF - Administration in Social Work
Y1 - 1997/12/04/
VL - 21
IS - 3/4
M3 - Article
SP - 9
EP - 29
SN - 03643107
AB - The authors trace the definition and challenges of “service integration,” variously known over time as “collaboration,” “coordination,” “human services integration,” and “one-stop shopping.” While the common use of service integration terminology currently may seem to indicate a consensus in favor of a broad systemic reform, motivations and expectations for service integration differ significantly among different players in the service system. The authors conclude that service integration cannot be defined by a particular service model or outcome, but instead should be conceived of as an ongoing reform process. This process, when well-designed and implemented with long-term vision, can reduce duplication, strengthen communities, and improve client outcomes. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Administration in Social Work is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75934496; Hasse, Seth 1; Austin, Michael J. 2; Affiliations: 1: Center for Mental Health Services, Substance Abuse and Mental Health Administration, Washington, DC, USA; 2: School of Social Welfare, University of California at Berkeley, Berkeley, CA, 94720, USA; Issue Info: Dec1997, Vol. 21 Issue 3/4, p9; Number of Pages: 21p; Document Type: Article
L3 - 10.1300/J147v21n03_02
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DP - EBSCOhost
DB - buh
ER -
TY - Gen
ID - 9999-01227-000
AN - 9999-01227-000
AU - Goldenhar, Linda M.
AU - Swanson, Naomi G.
AU - Hurrell, Joseph J. Jr.
AU - Ruder, Avima
AU - Deddens, James
T1 - Job Stressor Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1998///
AD - Goldenhar, Linda M., National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS-R16, Cincinnati, Ohio, United States, 45226
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-01227-000. Partial author list: First Author & Affiliation: Goldenhar, Linda M.; National Institute for Occupational Safety and Health, Cincinnati, Ohio, United States. Release Date: 20110912. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: Responses were provided using a variety of scales, including 4-point scales (e.g., strongly disagree to strongly agree), 5-point scales (e.g., never to always; strongly dissatisfied to strongly satisfied), summated scales (e.g., number of hours a day exposed to a hazardous condition), and 2-point scales (no-yes).. Language: English. Constructs: Job Stress; Job Satisfaction; Classification: Organizational, Occupational, and Career Development (7000); Physical Health/Illness Related Assessment (7300). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Interview
AB - Purpose: The purpose of the Job Stressor Questionnaire was to assess female construction workers' level of job satisfaction and psychological and physical health.
AB - Description: The Job Stressor Questionnaire (L. M. Goldenhar et al, 1998) was designed to assess female construction workers' level of job satisfaction and psychological and physical health. Sources for the individual test items included the NIOSH Job Stress Questionnaire (for questions measuring job control, job demands, job certainty, job satisfaction, responsibility, skill underuse, and social support), the NIOSH Management Commitment to Safety Scale, the Northwestern National Life Insurance Company Survey on Workplace Violence (for questions concerning physical health outcomes, sexual harassment, and discrimination), and the Profile of Mood States (to measure psychological symptoms). In addition, officials at the Laborers' International Union of North America provided lists of task-based exposures, and questions were developed to address these identified exposures. Questions about the amount and type of training received and the issue of having to constantly prove themselves were also included. The questionnaire was pretested with male and female construction workers, and a few minor wording changes were made on the basis of the results of the pretest. Then, female laborers were chosen as the study population. Items in the test were responded to using a variety of scales, including 4-point scales (e.g., strongly disagree to strongly agree), 5-point scales (e.g., never to always; strongly dissatisfied to strongly satisfied), summated scales (e.g., number of hours a day exposed to a hazardous condition), and 2-point scales (no-yes). For the most part, the items designed to measure specific constructs loaded on the expected factors. Alphas are provided for the following scales: supervisor-coworker support = .86, safety climate = .87, job certainty = .73, control = .72, harassment and discrimination = .75, job demands = .66, and training = .69. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Female Construction Workers
KW - Job Stressors
KW - Psychological Symptoms
KW - Physical Symptoms
KW - Job Satisfaction
KW - Internal Consistency
KW - Test Validity
KW - Questionnaire Development
U5 - Job Stressor Questionnaire [Test Development]Stressors and adverse outcomes for female construction workers. (AN: 1997-42744-002 from PsycINFO) Goldenhar, Linda M.; Swanson, Naomi G.; Hurrell, Joseph J. Jr.; Ruder, Avima; Deddens, James; Jan, 1998. Source: Journal of Occupational Health Psychology. 3(1), Educational Publishing Foundation, US; Jan, 1998; Administration: Interview Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: US; Sample: Male and Female Union Construction Workers Keywords: Female Construction Workers; Job Stressors; Psychological Symptoms; Physical Symptoms; Job Satisfaction; Internal Consistency; Test Validity; Questionnaire Development; Subjects: Blue Collar Workers; Employee Attitudes; Job Characteristics; Job Satisfaction; Nontraditional Careers; Occupational Stress; Physical Disorders; Psychiatric Symptoms; Telephone Surveys; Test Construction; Test Reliability; Test Validity; Working Women;
DO - 10.1037/t01227-000
L3 - Full; Full text; 999901227_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-18487-000
AN - 9999-18487-000
AU - Gong, Fang
AU - Xu, Jun
AU - Fujishiro, Kaori
AU - Takeuchi, David T.
T1 - Acculturative Stress Scale--Adapted
JF - PsycTESTS
JO - PsycTESTS
Y1 - 1998///
AD - Gong, Fang, Ball State University, Department of Sociology, Muncie, Indiana, United States, 47306
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-18487-000. Partial author list: First Author & Affiliation: Gong, Fang; Ball State University, Department of Sociology, Muncie, Indiana, United States. Release Date: 20130513. Correction Date: 20151109. Instrument Type: Rating Scale. Test Location: Appendix C, Page 1626. Test Format: Item responses range from Yes or No.. Language: English. Constructs: Acculturative Stress; Classification: Culture, Racial, and Ethnic Identity (5700). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300).
AB - Purpose: The Acculturative Stress Scale - Mexican American Prevalence and Services Survey assess stress related to culture change for immigrants.
AB - Description: Acculturative Stress Scale--Adapted (Fong et al., 2011) measures stress among immigrants related to culture change. This scale consists of 9 items adapted from the Mexican American Prevalence and Services Survey (MAPSS; Vega et al., 1998). Respondents must answer yes or no to the items regarding stress related to culture change (e.g. Do you feel guilty for leaving family or friends in your country of origin?). Following previous research (Gee et al., 2007), these nine items were summed to gauge the total level of acculturative stress experienced by individuals (KR-20= 0.60). Interaction terms were created between acculturative stress and human agency variables to test a stress-buffering hypothesis. Using Asian and Latino adults for the sample, the data suggests while acculturative stress increased psychological distress and the onset of recent depressive disorders, its effects were significantly or marginally weaker for individuals with multiple strong reasons for migration than those without clear reasons. The analysis did not yield significant interactions effects in predicting 12-month any anxiety disorders. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Acculturative Stress Scale--Adapted
KW - Immigration
U5 - Acculturative Stress Scale--Adapted [Test Development]A life course perspective on migration and mental health among Asian immigrants: The role of human agency. (AN: 2011-26416-008 from PsycINFO) Gong, Fang; Xu, Jun; Fujishiro, Kaori; Takeuchi, David T.; Dec, 2011. Source: Social Science & Medicine. 73(11), Elsevier Science, Netherlands; Dec, 2011; Age Group: Adulthood (18 yrs & older); Population: Human; Sample: Asian Immigrants; Latinos; Location: United States Keywords: Acculturative Stress Scale--Adapted; Immigration; Subjects: Acculturation; Adult Attitudes; Immigration; Rating Scales; Social Stress;
DO - 10.1037/t18487-000
L3 - Full; Full text; 999918487_full_001.pdf
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UR - fgong@bsu.edu
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 107245223
T1 - Commentary. Make a difference -- be a part of change.
AU - Harrison PL
Y1 - 1998/01//1998 Jan
N1 - Accession Number: 107245223. Language: English. Entry Date: 19980301. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8403379.
KW - Nursing as a Profession -- Trends
KW - Home Nursing, Professional -- Trends
SP - 64
EP - 64
JO - Home Healthcare Nurse
JF - Home Healthcare Nurse
JA - HOME HEALTHC NURSE
VL - 16
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0884-741X
AD - Washington County Public Health Service, Hudson Falls, New York
U2 - PMID: 9469076.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107239646
T1 - Device errors. Electronic fetal monitoring: are you monitoring mother or fetus?
AU - Swayze SC
Y1 - 1998/01//
N1 - Accession Number: 107239646. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Fetal Monitoring, Electronic -- Nursing
KW - Heart Rate, Fetal -- Evaluation
SP - 20
EP - 20
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Are you monitoring mother or fetus?
SN - 0360-4039
AD - Center for Radiological and Device Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9451211.
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DP - EBSCOhost
DB - rzh
ER -
TY - CASE
AU - Mileson, Beth E.
AU - Chambers, Janice E.
AU - Chen, W. L.
AU - Dettbarn, Wolf
AU - Ehrich, Marion
AU - Eldefrawi, Amira T.
AU - Gaylor, David W.
AU - Hamernik, Karen
AU - Hodgson, Ernest
AU - Karczmar, Alexander G.
AU - Padilla, Stephanie
AU - Pope, Carey N.
AU - Richardson, Ruby J.
AU - Saunders, Donald R.
AU - Sheets, Larry P.
AU - Sultatos, Lester G.
AU - Wallace, Kendall B.
T1 - Common Mechanism of Toxicity: A Case Study of Organophosphorus Pesticides.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1998/01//
VL - 41
IS - 1
M3 - Case Study
SP - 8
EP - 20
PB - Oxford University Press / USA
SN - 10966080
AB - The Food Quality Protection Act of 1996 (FQPA) requires the EPA to consider “available information concerning the cumulative effects of such residues and other substances that have a common mechanism of toxicity … in establishing, modifying, leaving in effect, or revoking a tolerance for a pesticide chemical residue.” This directive raises a number of scientific questions to be answered before the FQPA can be implemented. Among these questions is: What constitutes a common mechanism of toxicity? The ILSI Risk Science Institute (RSI) convened a group of experts to examine this and other scientific questions using the organophosphorus (OP) pesticides as the case study. OP pesticides share some characteristics attributed to compounds that act by a common mechanism, but produce a variety of clinical signs of toxicity not identical for all OP pesticides. The Working Group generated a testable hypothesis, anticholinesterase OP pesticides act by a common mechanism of toxicity, and generated alternative hypotheses that, if true, would cause rejection of the initial hypothesis and provide criteria for subgrouping OP compounds. Some of the alternate hypotheses were rejected outright and the rest were not supported by adequate data. The Working Group concluded that OP pesticides act by a common mechanism of toxicity if they inhibit acetylcholinesterase by phosphorylation and elicit any spectrum of cholinergic effects. An approach similar to that developed for OP pesticides could be used to determine if other classes or groups of pesticides that share structural and toxico-logical characteristics act by a common mechanism of toxicity or by distinct mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pesticides -- Toxicology
KW - Organophosphorus pesticides
KW - Food -- Quality -- Law & legislation
KW - United States. Environmental Protection Agency
N1 - Accession Number: 83181060; Mileson, Beth E. 1; Chambers, Janice E. 2; Chen, W. L. 3; Dettbarn, Wolf 4; Ehrich, Marion 5; Eldefrawi, Amira T. 6; Gaylor, David W. 7; Hamernik, Karen 8; Hodgson, Ernest 9; Karczmar, Alexander G. 10; Padilla, Stephanie 11; Pope, Carey N. 12; Richardson, Ruby J. 13; Saunders, Donald R. 14; Sheets, Larry P. 15; Sultatos, Lester G. 16; Wallace, Kendall B. 17; Affiliations: 1: ILSI Risk Science Institute; 2: Mississippi State University; 3: DowElanco; 4: Vanderbilt University; 5: VA-MD Regional College of Veterinary Medicine; 6: University of Maryland School of Medicine; 7: National Center for Toxicological Research FDA; 8: U.S. Environmental Protection Agency, OPP; 9: North Carolina State University; 10: Hines VA Hospital & Loyola University Medical Center; 11: U.S. Environmental Protection Agency, NHEERL; 12: Northeast Louisiana University; 13: University of Michigan; 14: Technology Services Group; 15: Department of Toxicology, Bayer Corporation; 16: UMD New Jersey Medical School; 17: University of Minnesota School of Medicine; Issue Info: 1998, Vol. 41 Issue 1, p8; Thesaurus Term: Pesticides -- Toxicology; Thesaurus Term: Organophosphorus pesticides; Subject Term: Food -- Quality -- Law & legislation ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 13p; Document Type: Case Study
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bwire, R.
AU - Slootman, E. J. H.
AU - Verhave, J. P.
AU - Bruins, J.
AU - Docters van Leeuwen, W. M.
T1 - Malaria anticircumsporozoite antibodies in dutch soldiers returning from sub-saharan africa.
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
Y1 - 1998/01//
VL - 3
IS - 1
M3 - Article
SP - 66
EP - 69
SN - 13602276
AB - One hundred and twenty-five Dutch servicemen returning from central Africa after a short deployment were enrolled in a study aimed at assessing the effectiveness of malaria prevention measures. None of the persons developed an episode of clinically overt malaria during or after deployment, and no antibodies against blood stages of Plasmodium falciparum could be found. However, antibodies against the circumsporozoite protein (CS) of P. falciparum were demonstrable in 14 persons (11.2% of the study population) by an ELISA test using the recombinant CS-antigen R32tet32, while one person only was positive in an IFA test based on schizonts of P. fieldi as antigen. We concluded that the anti-CS-positive servicemen were probably bitten by mosquitoes carrying P. falciparum parasites while the IFA-positive person was possibly infected by P. vivax , P. ovale or P. malariae parasites. There was no significant association between the different antimalaria preventive measures and the development of anti-CS antibodies. Therefore mefloquine prophylaxis as the single most widely used preventive measure in this group of servicemen was possibly a major contributing factor in averting development of overt malaria.. [ABSTRACT FROM AUTHOR]
AB - Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA -- Prevention
KW - MILITARY personnel
KW - NETHERLANDS
KW - antibodies
KW - circumsporozoite protein
KW - P. falciparum
KW - P. fieldi
KW - P. malariae
KW - P. ovale
KW - P. vivax
N1 - Accession Number: 5089239; Bwire, R. 1; Slootman, E. J. H. 1,2; Verhave, J. P. 3; Bruins, J. 2; Docters van Leeuwen, W. M. 4; Source Information: Jan1998, Vol. 3 Issue 1, p66; Subject: MALARIA -- Prevention; Subject: MILITARY personnel; Geographic Terms: NETHERLANDS; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: circumsporozoite protein; Author-Supplied Keyword: P. falciparum; Author-Supplied Keyword: P. fieldi; Author-Supplied Keyword: P. malariae; Author-Supplied Keyword: P. ovale; Author-Supplied Keyword: P. vivax; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1046/j.1365-3156.1998.00165.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Robert, B. Nussenblatt
AU - bron, Anthony
AU - Chambers, Wiley
AU - James, P. McCulley
AU - Pericoi, Marc
AU - John, L. Ubels
AU - Henry, F. Edelhauser
T1 - Ophthalmologic Perspectives on Eye Irritation Testing.
JO - Journal of Toxicology -- Cutaneous & Ocular Toxicology
JF - Journal of Toxicology -- Cutaneous & Ocular Toxicology
Y1 - 1998/01/02/
VL - 17
IS - 2/3
M3 - Article
SP - 103
EP - 109
SN - 07313829
N1 - Accession Number: 78466773; Robert, B. Nussenblatt 1; bron, Anthony 2; Chambers, Wiley 3; James, P. McCulley 4; Pericoi, Marc 5; John, L. Ubels 6; Henry, F. Edelhauser 7; Affiliations: 1: National Eye Institute National Institutes of Health, Bethesda, Maryland; 2: Nuffield Laboratory of Ophthalmology Oxford, United Kingdom; 3: U.S. Food and Drug Administration, Washington, D.C.; 4: University of Texas Southwestern Medical School Dallas, Texas; 5: Peritesco Paris, France; 6: Calvin College Grand Rapids, Michigan; 7: Emory University Atlanta, Georgia; Issue Info: 1998, Vol. 17 Issue 2/3, p103; Number of Pages: 7p; Document Type: Article
L3 - 10.3109/15569529809049311
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104797298
T1 - Effect of orifice-area reduction on flow characteristics during injection through spinal needles.
AU - Myers, M R
AU - Malinauskas, R A
Y1 - 1998/02//
N1 - Accession Number: 104797298. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0370524.
KW - Anesthesia, Spinal -- Equipment and Supplies
KW - Anesthetics -- Administration and Dosage
KW - Needles
KW - Computer Simulation
KW - Drug Administration Schedule
KW - Rheology
SP - 151
EP - 156
JO - Anaesthesia
JF - Anaesthesia
JA - ANAESTHESIA
VL - 53
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0003-2409
AD - Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD 20852, USA.
U2 - PMID: 9534638.
DO - 10.1046/j.1365-2044.1998.00286.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104797298&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Ellenberg, S. S.;
T1 - Commentary on surrogate endpoints in AIDS drug development: current status, by Christy Chuang-Stein and Ralph DeMasi
CT - Commentary on surrogate endpoints in AIDS drug development: current status, by Christy Chuang-Stein and Ralph DeMasi
JO - Drug Information Journal (USA)
JF - Drug Information Journal (USA)
Y1 - 1998/02/01/
VL - 32
IS - Feb
SP - 449
EP - 452
SN - 00928615
AD - Division of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM-210, Rockville, MD 20852-1448, USA
N1 - Accession Number: 36-01722; Language: English; References: 20; Journal Coden: DGIJB9; Section Heading: Methodology; Sociology, Economics and Ethics; Abstract Author: Ellen Katz Neumann
N2 - A commentary on a discussion of the search for surrogate markers in the evaluation of drugs being developed for the treatment of acquired immunodeficiency syndrome (AIDS) and the appropriateness of this strategy is presented.
KW - Acquired immunodeficiency syndrome--antiretroviral agents--surrogate endpoints;
KW - Antiretroviral agents--acquired immunodeficiency syndrome--surrogate endpoints;
KW - Methodology--acquired immunodeficiency syndrome--surrogate endpoints;
KW - Product development--antiretroviral agents--surrogate endpoints;
KW - Research--antiretroviral agents--surrogate endpoints;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=36-01722&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107264606
T1 - A conceptual model of occupational health nursing: the Resource Model.
AU - Slagle MW
AU - Sun SM
AU - Mathis MG
Y1 - 1998/03//1998 Mar
N1 - Accession Number: 107264606. Language: English. Entry Date: 19980601. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669.
KW - Occupational Health Nursing
KW - Nursing Models, Theoretical
KW - Nursing Role
KW - Scope of Nursing Practice
KW - Consumers
KW - Work Environment
KW - Social Networks
KW - Job Description
KW - Philosophy, Nursing
KW - Safety
KW - Nursing Process
KW - Occupational Health Services
SP - 121
EP - 126
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 46
IS - 3
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - Conceptual models provide an important framework for the development and implementation of a successful occupational health program. The Resource Model incorporates the varied resources available from the worksite, community, and professional realms. Although the domain of the client focuses on the workplace, the concept of 'client' may include individuals in the workplace, as well as workers' families, the worksite organization, and the local community. Using a collaborative team process, the occupational health nurse is a leader and coordinator maximizing resources for the most appropriate and realistic health and safety program.
SN - 0891-0162
AD - U.S. Public Health Service, Federal Occupational Health, Seattle, WA
U2 - PMID: 9582728.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107264606&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rosenstock, Linda
AU - Olenec, Christopher
AU - Wagner, Gregory R.
T1 - The National Occupational Research Agenda: A Model of Broad Stakeholder Input into Priority Setting.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/03//
VL - 88
IS - 3
M3 - Article
SP - 353
EP - 356
PB - American Public Health Association
SN - 00900036
AB - Objectives. No single organization has the resources necessary to conduct occupational safety and health research to adequately serve the needs of workers in the United Stales. The National Institute for Occupational Safety and Health (NIOSH) undertook the task of setting research priorities in response to a broadly perceived need to systematically address those topics most pressing and most likely to yield gains to workers and to the nation. Methods. NIOSH and its public and private partners used a consensus-building process to set priorities for the next decade for occupational safety and health research the National Occupational Research Agenda. Results. The process resulted in the identification of 21 research priorities grouped into 3 categories: disease and injury, work environment and workforce, and research tools and approaches. Conclusions. Although the field of occupational safety and health is often contentious and adversarial, these research priorities reflect a remarkable degree of concurrence among a broad range of stakeholders who provided input into a clearly defined and open process. (Am J Public Health. 1998;88:353-356) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 453209; Rosenstock, Linda 1; Olenec, Christopher 1; Wagner, Gregory R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Washington, DC; Issue Info: Mar98, Vol. 88 Issue 3, p353; Thesaurus Term: Industrial hygiene ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article; Full Text Word Count: 2265
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107277629
T1 - Public health policy forum. The National Occupational Research Agenda: a model of broad stakeholder input into priority setting.
AU - Rosenstock L
AU - Olenec C
AU - Wagner GR
Y1 - 1998/03//
N1 - Accession Number: 107277629. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; algorithm; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Research Priorities
KW - Occupational Safety
KW - National Institute for Occupational Safety and Health
SP - 353
EP - 356
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 3
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: No single organization has the resources necessary to conduct occupational safety and health research to adequately serve the needs of workers in the United States. The National Institute for Occupational Safety and Health (NIOSH) undertook the task of setting research priorities in response to a broadly perceived need to systematically address those topics most pressing and most likely to yield gains to workers and to the nation. METHODS: NIOSH and its public and private partners used a consensus-building process to set priorities for the next decade for occupational safety and health research--the National Occupational Research Agenda. RESULTS: The process resulted in the identification of 21 research priorities grouped into 3 categories: disease and injury, work environment and workforce, and research tools and approaches. CONCLUSIONS: Although the field of occupational safety and health is often contentious and adversarial, these research priorities reflect a remarkable degree of concurrence among a broad range of stakeholders who provided input into a clearly defined and open process.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, 200 Independence Ave, SW, Washington, DC 20201
U2 - PMID: 9518963.
DO - 10.2105/AJPH.88.3.353
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rosa, Roger R.
AU - Bonnet, Michael H.
AU - Cole, Libby L.
AU - Rosa, R R
AU - Bonnet, M H
AU - Cole, L L
T1 - Work schedule and task factors in upper-extremity fatigue.
JO - Human Factors
JF - Human Factors
Y1 - 1998/03//
VL - 40
IS - 1
M3 - journal article
SP - 150
EP - 158
SN - 00187208
AB - We tested the combined effects of work schedule and task factors on upper-extremity fatigue in the laboratory during 8-h and 12-h shift schedules. Participants performed a simulated manual assembly task at three repetition rates and three torque loads and self-adjusted their work cycle duration to maintain fatigue at moderate levels. Work cycle durations decreased with increases in both load level and repetition rate. Fatigue was observed more quickly with increasing time on shifts and during night shifts compared with day shifts. Work schedule effects were most apparent at lighter workloads, with minimal differences at higher workloads. The highest fatigue levels were observed during 12-h night shifts, with similar levels reached by the end of both the week of 8-h night shifts and the week of 12-h day shifts. Overall durations were 20%-30% shorter than in previous short-term studies, which was likely a result of the more realistic work schedules used in this study. Results from this study could be applied to the design of work-rest schedules for manual tasks involving the upper extremities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Working hours
KW - Fatigue
N1 - Accession Number: 549627; Rosa, Roger R.; Bonnet, Michael H.; Cole, Libby L.; Rosa, R R 1; Bonnet, M H; Cole, L L; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226, USA; Issue Info: Mar1998, Vol. 40 Issue 1, p150; Subject Term: Working hours; Subject Term: Fatigue; Number of Pages: 9p; Illustrations: 1 Chart, 10 Graphs; Document Type: journal article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Lechter, Karen
AU - Weintraub, Michael
AU - Bowen, Debra
T1 - Comprehension Testing for OTC Drug Labels: Goals, Methods, Target Population, and Testing Environment.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1998///Spring98
VL - 17
IS - 1
M3 - Article
SP - 86
EP - 96
PB - American Marketing Association
SN - 07439156
AB - Drug products may be switched from precription (Rx) to over-the-counter (OTC) status if labeling can be written that ensures that the label information is comprehensible to ordinary consumers, including persons with low literacy ability, under normal conditions of purchase and use. The Food and Drug Administration has been working with sponsors to develop methods to test consumer comprehension of proposed OTC product labels. The authors discuss several conceptual and operational elements of comprehension testing, focusing on the goals, methods, appropriate target audience, and testing environment. The authors also examine areas in need of further research and debate. As more complex products are considered for OTC status, it is even more important to ensure that OTC labels are comprehensible. As understanding and the validity of methods to evaluate consumer comprehension improve, so should the quality of labels offered to consumers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Consumers
KW - Nonprescription drugs
KW - Labels
KW - Health products
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 701306; Morris, Louis A. 1; Lechter, Karen 2; Weintraub, Michael 2; Bowen, Debra 2; Affiliations: 1: Senior Vice President of PRR Inc.; 2: Division of Drug Marketing, Advertising and Communications (HFD-40) and the Office of Drug Evaluation V (HFD-500), Food and Drug Administration (FDA).; Issue Info: Spring98, Vol. 17 Issue 1, p86; Thesaurus Term: Consumers; Subject Term: Nonprescription drugs; Subject Term: Labels; Subject Term: Health products; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 107160554
T1 - News from the field. Healthy People 2010.
AU - Yu SM
Y1 - 1998/03//
N1 - Accession Number: 107160554. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. NLM UID: 9715672.
KW - United States Department of Health and Human Services -- Standards
KW - Organizational Objectives
KW - Maternal-Child Health
KW - Health Policy
KW - Child Mortality
KW - Infant Mortality
KW - Maternal Mortality
KW - Maternal Health Services
KW - Obstetric Care
KW - Substance Abuse, Perinatal
KW - Neural Tube Defects
KW - Breast Feeding
KW - Health Screening
KW - Genetic Screening
KW - Infant, Newborn
KW - Pregnancy
KW - Female
KW - Fetus
SP - 63
EP - 66
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 2
IS - 1
CY - ,
PB - Springer Science & Business Media B.V.
AB - In the year 2000, the U.S. Department of Health and Human Services will release Healthy People 2010, the third set of health-promotion and disease-prevention objectives for the nation. One of the focus areas within these objectives is maternal and infant health. This focus area comprises objectives addressing maternal health status and risk factors; infant health status, risk factors, and outcomes; and the use of essential health services by pregnant women, infants, and women of childbearing age. The objectives in this focus area were developed by a multidisciplinary, interagency working group coordinated by the Maternal and Child Health Bureau. The workgroup proposed 39 objectives in 12 clusters. This article presents these objectives and their associated baseline data and targets for the year 2010. Members of the MCH community are encouraged to review and comment on these objectives during the public comment period.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Division of Science, Education and Analysis, Parklawn Building, Room 18A-55, 5600 Fishers Lane, Rockville, Maryland 20857. E-mail: syu@hrsa.dhhs.gov
U2 - PMID: 10728261.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yu, Stella M.
T1 - Healthy People 2010.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1998/03//
VL - 2
IS - 1
M3 - Article
SP - 63
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - In the year 2000, the U.S. Department of Health and Human Services will release Healthy People 2010 , the third set of health-promotion and disease-prevention objectives for the nation. One of the focus areas within these objectives is maternal and infant health. This focus area comprises objectives addressing maternal health status and risk factors; infant health status, risk factors, and outcomes; and the use of essential health services by pregnant women, infants, and women of childbearing age. The objectives in this focus area were developed by a multidisciplinary, interagency working group coordinated by the Maternal and Child Health Bureau. The workgroup proposed 39 objectives in 12 clusters. This article presents these objectives and their associated baseline data and targets for the year 2010. Members of the MCH community are encouraged to review and comment on these objectives during the public comment period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - PREGNANT women
KW - INFANT health services
KW - UNITED States. Dept. of Health & Human Services
KW - UNITED States
KW - breastfeeding
KW - child health
KW - health policy
KW - infant mortality
KW - low birthweight
KW - Maternal and infant health
KW - prenatal care
N1 - Accession Number: 11307750; Yu, Stella M. 1,2; Email Address: syu@hrsa.dhhs.gov; Source Information: Mar1998, Vol. 2 Issue 1, p63; Subject: HEALTH promotion; Subject: PREGNANT women; Subject: INFANT health services; Subject: UNITED States. Dept. of Health & Human Services; Geographic Terms: UNITED States; Author-Supplied Keyword: breastfeeding; Author-Supplied Keyword: child health; Author-Supplied Keyword: health policy; Author-Supplied Keyword: infant mortality; Author-Supplied Keyword: low birthweight; Author-Supplied Keyword: Maternal and infant health; Author-Supplied Keyword: prenatal care; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107251924
T1 - Device errors. Implanted pacemakers... avoiding electromagnetic interference... cellular phone use.
AU - Dwyer D
Y1 - 1998/03//
N1 - Accession Number: 107251924. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Pacemaker, Artificial
KW - Electromagnetic Fields
KW - Telephone
KW - Wireless Communications
KW - Equipment Failure
SP - 70
EP - 70
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107204470
T1 - Risky business: challenges in vaccine risk communication.
AU - Ball LK
AU - Evans G
AU - Bostrom A
Y1 - 1998/03//Mar98 Part 1 of 2
N1 - Accession Number: 107204470. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Mar98 Part 1 of 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Vaccines -- Adverse Effects
KW - Communication
KW - Immunization -- Adverse Effects
KW - Risk Assessment
SP - 453
EP - 458
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 101
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM #475, 1401 Rockville Pike, Rockville, MD 20852
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107284869
T1 - Nursing as a road to public policy.
AU - Ford-Roegner PA
Y1 - 1998/03//1998 Mar
N1 - Accession Number: 107284869. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9431621.
KW - Careers in Nursing
KW - Career Mobility
KW - Politics
KW - Public Policy
SP - 47
EP - 50
JO - Seminars for Nurse Managers
JF - Seminars for Nurse Managers
JA - SEMIN NURSE MANAGERS
VL - 6
IS - 1
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Nursing provides a versatile base for broader career possibilities. This Presidential appointee in the Clinton Administration describes her path from nursing to public policy maker. Copyright (c) 1998 by W.B. Saunders Company
SN - 1066-3851
AD - US Department of Health and Human Services, Atlanta Federal Center, 61 Forsyth St SW, Atlanta, GA 30303
U2 - PMID: 9801656.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107296357
T1 - Energy, macronutrient, and food intakes in relation to energy compensation in consumers who drink different types of milk.
AU - Lee HHC
AU - Gerrior SA
AU - Smith JA
Y1 - 1998/04//
N1 - Accession Number: 107296357. Language: English. Entry Date: 19981101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Dietary Fats -- Administration and Dosage
KW - Milk
KW - Energy Intake
KW - Diet
KW - Surveys
KW - Comparative Studies
KW - Sampling Methods
KW - Data Analysis Software
KW - T-Tests
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Human
SP - 616
EP - 623
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 67
IS - 4
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - To examine whether total fat intake is actually lower in reduced-fat (low-fat and skim) milk drinkers and whether reduced-fat-milk drinkers compensate for energy intake we compared the intakes of foods, energy, and energy-yielding nutrients in reduced-fat-milk drinkers and whole milk drinkers by using the US Department of Agriculture's 1989-1991 nationwide food intake database, the Continuing Survey of Food Intakes by Individuals. This database represents a national stratified sample population of 15 128 individuals. Of the survey population, approximately one-third consumed whole milk, one-third consumed low-fat milk, one-tenth consumed skim milk, and one-tenth consumed mixed types of milk. The data provided the following information: 1) total fat intake of reduced-fat-milk drinkers is significantly (P < or = 0.05) lower than that of whole milk drinkers; 2) in general, males but not females compensate for energy by increasing their carbohydrate intake; 3) reduced-fat-milk drinkers consume more fruit and vegetables (P < or = 0.05) and less red meat and sweets (P < or = 0.05) than whole milk drinkers; 4) through their reduction in total fat intake, several age groups of skim milk drinkers have achieved the US dietary goal for fat intake, ie, < or = 30% of energy intake from fat; 5) teenagers compensate for energy intake the least of all age groups; and 6) with advancing age, fewer people drink milk and fewer drink whole milk. The data indicate significant sex differences in energy compensation, that reduced-fat-milk drinkers consume significantly (P < or = 0.05) less fat than whole milk drinkers, and that the US dietary goal for fat intake may be practically achieved by consuming reduced-fat foods such as skim milk and limiting intakes of high-fat foods such as red meat.
SN - 0002-9165
AD - The Center for Food Safety and Applied Nutrition, Food and Drug Administration and Human Nutrition Information Service, US Department of Agriculture, Washington, DC. E-mail: hcl@vm.cfsan.fda.gov
U2 - PMID: 9537608.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fintor, Lou
AU - Brown, Martin
AU - Fischer, Ruth
AU - Suleiman, Orhan
AU - Garlinghouse, Carol
AU - Camburn, James
AU - Frazier, Emma
AU - Houn, Florence
T1 - The Impact of Mammography Quality Improvement Legislation in Michigan: Implications for the National Mammography Quality Standards Act.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/04//
VL - 88
IS - 4
M3 - Article
SP - 667
EP - 671
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the impact of state legislation on mammography quality and access in Michigan. Methods. The impact of state legislation was analyzed with respect to utilization, numbers of machines and facilities, and image quality. Results. The legislation had a positive effect on image quality improvement, had no impact on utilization by women aged 50 years and above, and resulted in few facility closures. Conclusions. Michigan's legislative intervention appears to have had a positive effect on efforts to improve mammography quality assurance with implications for other federal and state efforts to achieve quality assurance in health care delivery. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mammograms
KW - Breast exams
KW - Breast cancer
KW - Medical laws & legislation
KW - Medical care
KW - Michigan
N1 - Accession Number: 1138009; Fintor, Lou; Brown, Martin; Fischer, Ruth 1; Suleiman, Orhan 1; Garlinghouse, Carol 2; Camburn, James 3; Frazier, Emma; Houn, Florence 1; Affiliations: 1: Division of Mammography Quality and Radiation Programs. Food and Drug Administration, Rockville, Md.; 2: Center for Health Promotion and Chronic Disease Prevention, Michigan Department of Community Health Lansing; 3: Bureau of Health Systems, Michigan Department of Consumer and Industry Services, Lansing; Issue Info: Apr98, Vol. 88 Issue 4, p667; Subject Term: Mammograms; Subject Term: Breast exams; Subject Term: Breast cancer; Subject Term: Medical laws & legislation; Subject Term: Medical care; Subject: Michigan; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 2799
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107266486
T1 - From the Food and Drug Administration. FDA Public Health Advisory: low molecular-weight heparin and spinal/epidural anesthesia or spinal puncture.
AU - Lumpkin MM
Y1 - 1998/04//1998 Apr-Jun
N1 - Accession Number: 107266486. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Hematoma, Epidural -- Chemically Induced
KW - Heparin -- Adverse Effects
KW - Anesthesia, Spinal -- Adverse Effects
KW - Anesthesia, Epidural -- Adverse Effects
KW - United States Food and Drug Administration
KW - Hematoma, Epidural
KW - Aged
KW - Female
SP - 56
EP - 57
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 4
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857
U2 - PMID: 9855967.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107275803
T1 - Consistency in maintaining contact with HIV-related service providers: an analysis of the AIDS Cost and Services Utilization Study (ACSUS)
AU - Niemcryk SJ
AU - Bedros A
AU - Marconi KM
AU - O'Neill JF
Y1 - 1998/04//
N1 - Accession Number: 107275803. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7600747.
KW - HIV-Infected Patients
KW - Health Resource Utilization
KW - Prospective Studies
KW - Surveys
KW - Independent Variable
KW - Dependent Variable
KW - Stratified Random Sample
KW - Questionnaires
KW - Interviews
KW - Multivariate Analysis
KW - Summated Rating Scaling
KW - Logistic Regression
KW - Odds Ratio
KW - Socioeconomic Factors
KW - Health Status
KW - Support Groups
KW - Emergency Care -- Utilization
KW - Hospitalization
KW - Outpatient Service
KW - Dental Care for Chronically Ill
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Drug Rehabilitation Programs
KW - Substance Abuse, Intravenous
KW - Gay Men
KW - Heterosexuality
KW - Human
SP - 137
EP - 152
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 23
IS - 2
CY - ,
PB - Springer Science & Business Media B.V.
AB - Patients (n = 1949) infected with HIV were recruited for the AIDS Cost & Service Utilization Survey (ACSUS) from ten U.S. cities and administered face to face interviews at three month intervals over an 18 month period from. The interview was designed to obtain information at each wave of data collection on the use of the following services: ambulatory care, hospitalization, emergency room use, support groups/counseling, drug and alcohol treatment, and dental care. Patients were found to be highly consistent in their patterns of utilization across time, regardless of the service in question. Of the patients who reported using an emergency room (ER) at Time 1, 52% also reported using an ER during the next three months later at Time 2. Of those who reported having been hospitalized during the Time I reporting period, almost 58% reported a hospitalization again at Time 2. Next, use of a service at Time 6 (n = 1404, 72.2%) was regressed onto whether the person received the service at Time 2 and the personal, financial, and medical variables, Except for dental services, utilization of a service one year in the past (Time 2) was the strongest predictor of Time 6 use. The findings indicated that the one factor consistently related to service use within this sample is a factor (as opposed to education, race, or even insurance) that is amenable to intervention: previous use of that service. The individuals studied established patterns of service utilization that are of reasonably long duration once they began use of a service. This continuity of care becomes more critical as the initiation of treatments begins with the diagnosis of HIV rather than AIDS. Findings suggest that HIV outreach efforts be targeted to increasing early use of medical and behavioral services in ambulatory care settings.
SN - 0094-5145
AD - Chief, Epidemiology and Data Analysis Branch, Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane (7A-07), Rockville, MD 20857
U2 - PMID: 9591205.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107275803&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107266051
T1 - Device errors. Safeguarding cardiac guide wires... avoid breakage.
AU - Michaloski C
Y1 - 1998/04//
N1 - Accession Number: 107266051. Language: English. Entry Date: 19980601. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Angioplasty, Transluminal, Percutaneous Coronary -- Adverse Effects
KW - Angioplasty, Transluminal, Percutaneous Coronary -- Equipment and Supplies
KW - Equipment Failure
SP - 22
EP - 22
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Epidemiologist, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9601375.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107266051&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107285674
T1 - Scheduled intermittent hospitalization for psychiatric patients.
AU - Dilonardo JD
AU - Connelly CE
AU - Gurel L
AU - Seifert RF
AU - Kendrick K
AU - Deutsch SI
Y1 - 1998/04//1998 Apr
N1 - Accession Number: 107285674. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Rosenberg Self-Esteem Scale; Personal Adjustment and Role Skills Scale (PAL-C); Brief Psychiatric Rating Scale (BPRS); Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L). Grant Information: Health Services Research and Development grants 87-021 and 90-904 from the Department of Veterans Affairs. NLM UID: 9502838.
KW - Appointments and Schedules
KW - Hospitals, Veterans -- Utilization
KW - Mental Disorders -- Therapy
KW - Patient Care Plans -- Standards
KW - Hospitalization
KW - Center for Epidemiological Studies Depression Scale
KW - Scales
KW - Psychological Tests
KW - Rosenberg Self Esteem Scale
KW - Chi Square Test
KW - Psychiatric Emergencies
KW - Hospitals, Veterans -- Standards
KW - Prospective Studies
KW - Patient Compliance
KW - Mental Disorders -- Psychosocial Factors
KW - Length of Stay
KW - Readmission
KW - Patient Satisfaction
KW - Funding Source
KW - Treatment Outcomes
KW - Social Adjustment
KW - Self Concept
KW - Regression
KW - Psychiatric Units -- Utilization
KW - P-Value
KW - DSM
KW - Experimental Studies
KW - United States
KW - Power Analysis
KW - Coefficient Alpha
KW - Random Assignment
KW - Clinical Trials
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Human
SP - 504
EP - 509
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 49
IS - 4
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: The effect of scheduled intermittent hospitalization on the hospital utilization, community adjustment, and self-esteem of persons with serious and persistent mental illness was examined in an experimental study. METHODS: Fifty-seven male veterans, aged 65 or younger, with a primary axis I psychiatric diagnosis who were frequent utilizers of inpatient care over the previous two years were randomly assigned to two groups. Patients in the experimental group were prescheduled for four hospital admissions, each lasting nine to 11 days, per year for two years. Patients in the control group had traditional access to hospital care. Psychiatric bed days, community adjustment, and self-esteem were assessed during and after the intervention. RESULTS: No differences between the groups on demographic or clinical variables were detected at study entry. The experimental group showed improvement in self-esteem, affect, and complaints of physical symptoms at one year. No statistically significant differences between groups were found in hospital utilization, financial management, substance abuse, or psychological well-being at one year. CONCLUSIONS: Scheduled intermittent hospitalization may be an appropriate and promising alternative to traditional care for revolving-door patients. This intervention could maintain patients at a higher level of wellness than traditional care and reduce the recurrence of the crises that precipitate hospitalization.
SN - 1075-2730
AD - Center for Substance Abuse Treatment, Rockville, Maryland
U2 - PMID: 9550241.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107285674&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Egeland, Grace M.
AU - Perham-Hester, Katherine A.
AU - Gessner, Bradford D.
AU - Ingle, Diane
AU - Berner, James E.
AU - Middaugh, John P.
T1 - Fetal Alcohol Syndrome in Alaska, 1977 through 1992: An administrative Prevalence Derived from Multiple Data Sources.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/05//
VL - 88
IS - 5
M3 - Article
SP - 781
EP - 786
PB - American Public Health Association
SN - 00900036
AB - Objectives. The prevalence and characteristics of fetal alcohol syndrome cases and the usefulness of various data sources in surveillance were examined in Alaska to guide prevention and future surveillance efforts. Methods. Sixteen data sources in Alaska were used to identify children with fetal alcohol syndrome. Medical charts were reviewed to verify cases, and records were reviewed to provide descriptive data. Results. Fetal alcohol syndrome rates varied markedly by birth year and race, with the highest prevalence (4.1 per 1000 live births) found among Alaska Natives born between 1985 and 1988. Screening and referral programs to diagnostic clinics identified 70% of `all recorded eases. The intervention program for children 0 to 3 years of age detected 29% of age-appropriate cases, and Medicaid data identified 11% of all cases; birth certificates detected only 9% of the age-appropriate cases. Conclusions. Our findings indicate a high prevalence of fetal alcohol syndrome in Alaska and illustrate that reliance on any one data source would lead to underestimates of the extent of fetal alcohol syndrome in a population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fetal alcohol syndrome
KW - Juvenile diseases
KW - Medical screening
KW - Medical referral
KW - Alaska
N1 - Accession Number: 923636; Egeland, Grace M. 1; Perham-Hester, Katherine A. 2; Gessner, Bradford D. 2; Ingle, Diane 2; Berner, James E. 3; Middaugh, John P. 2; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, and the Division of Public Health, Alaska Department of Health and Social Services, Anchorage.; 2: Division of Public Health, Alaska Department of Health and Social Services; 3: Indian Health Service, Alaska Area Native Health Service, Anchorage; Issue Info: May98, Vol. 88 Issue 5, p781; Subject Term: Fetal alcohol syndrome; Subject Term: Juvenile diseases; Subject Term: Medical screening; Subject Term: Medical referral; Subject: Alaska; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 5215
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gaston, Marilyn H.
AU - Barrett, Sharon E.
AU - Johnson, Tamara Lewis
AU - Epstein, Leonard G.
T1 - HEALTH CARE NEEDS OF MEDICALLY UNDESERVED WOMEN OF COLOR: The Role of the Bureau of Primary Health Care.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1998/05//
VL - 23
IS - 2
M3 - Article
SP - 86
EP - 95
PB - Oxford University Press / USA
SN - 03607283
AB - This article focuses on the role of Bureau of Primary Health Care (BPHC), Office of Minority and Women's Health (OMWH), and their legislative mission to enhance the health status of underserved and vulnerable women and their children; to briefly review some of the background data on the medically underserved and the particular status of women of color within that population; to identify a series of questions to help frame the policy dialogue for developing services to medically underserved women of color; and to invite dialogue, feedback, and participation with social workers around a number of these key questions and issues that can help guide our collective vision and health care initiatives for the medically underserved over the next several years. One of the most significant problems for underserved populations is their inability to obtain health care services in the marketplace. The major disparities in health care that pervade the lives of medically underserved women of color, their families, and communities have plagued the United States and all health care professions for decades. Medically underserved women need the human services professions to assist in removing fundamental barriers that restrict their ability to maintain their health, the health of their families, and their communities. Part of that responsibility rests with BPHC and OMWH.
KW - WOMEN -- United States
KW - MEDICAL care
KW - MEDICALLY underserved areas
KW - PUBLIC health
KW - WOMEN of color
KW - UNITED States
KW - accessibility of services
KW - HEALTH AND HUMAN RESOURCES
KW - health care utilization
KW - racial differences women
N1 - Accession Number: 590881; Gaston, Marilyn H. 1,2; Barrett, Sharon E. 3; Johnson, Tamara Lewis 4; Epstein, Leonard G. 5; Source Information: May1998, Vol. 23 Issue 2, p86; Subject: WOMEN -- United States; Subject: MEDICAL care; Subject: MEDICALLY underserved areas; Subject: PUBLIC health; Subject: WOMEN of color; Geographic Terms: UNITED States; Author-Supplied Keyword: accessibility of services; Author-Supplied Keyword: HEALTH AND HUMAN RESOURCES; Author-Supplied Keyword: health care utilization; Author-Supplied Keyword: racial differences women; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6908
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107282859
T1 - Health care needs of medically underserved women of color: the role of the Bureau of Primary Health Care.
AU - Gaston MH
AU - Barrett SE
AU - Johnson TL
AU - Epstein LG
Y1 - 1998/05//
N1 - Accession Number: 107282859. Language: English. Entry Date: 20050425. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 7611528.
KW - Poverty
KW - Women
KW - Minority Groups
KW - Government Agencies
KW - Health Services Accessibility
KW - Health Status
KW - Primary Health Care
KW - Collaboration
KW - Conceptual Framework
KW - Cultural Competence
KW - Female
SP - 86
EP - 95
JO - Health & Social Work
JF - Health & Social Work
JA - HEALTH SOC WORK
VL - 23
IS - 2
PB - Oxford University Press / USA
AB - The Bureau of Primary Health Care (BPHC) was developed to increase access to comprehensive primary and preventive health care and to improve the health status of medically underserved populations. Approximately 43 million Americans fall into this category, and the majority are poor, female, young, and uninsured. Under the Public Health Services Act, BPHC does not provide direct services, but rather assists local communities in identifying populations at risk of poor health outcomes and helps these communities through various programs. One of the newest initiatives of BPHC is the Office of Minority and Women's Health, developed with a mission to help reduce the disparities in the health status of women of racial and ethnic minority populations. This article outlines these disparities and discusses proposals for reducing them.
SN - 0360-7283
AD - Associate Administrator for Primary Health Care, Health Resources and Services Administration, Bureau of Primary Health Care (BPHC)
U2 - PMID: 9598391.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107282859&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107159607
T1 - HIV Healthcare delivery and managed care: applications and implications from the Special Projects of National Significance program.
AU - Gamliel S
AU - Singer B
AU - Marconi K
Y1 - 1998/05//
N1 - Accession Number: 107159607. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128.
KW - Home Health Care -- Trends
KW - HIV Infections -- Therapy
KW - Managed Care Programs -- Trends
KW - Health Care Reform
KW - Grants
SP - 101
EP - 109
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 17
IS - 1
PB - Taylor & Francis Ltd
SN - 0162-1424
AD - Health Resources and Services Administration for Special Projects of National Significance, Rockville, Maryland
U2 - PMID: 10338805.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107159607&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaylor, D.
T1 - Safety assessment with hormetic effects.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 1998/05//
VL - 17
IS - 5
M3 - Article
SP - 251
EP - 253
PB - Sage Publications, Ltd.
SN - 09603271
AB - Discusses the safety of a nonessential chemical. Safety assessment; Disease incidence rates at selected doses for five human subpopulations; Beneficial doses relative to the reference dose for typical hormetic effects.
KW - Chemicals
KW - Hormesis
N1 - Accession Number: 4664258; Gaylor, D. 1; Affiliations: 1: Food and Drug Administration, National Center for Toxicological Research; Issue Info: 1998, Vol. 17 Issue 5, p251; Subject Term: Chemicals; Subject Term: Hormesis; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Manderscheid, Ronald W.
AU - Manderscheid, R W
T1 - From many into one: addressing the crisis of quality in managed behavioral health care at the millennium.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 1998/05//
VL - 25
IS - 2
M3 - journal article
SP - 233
EP - 237
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - Emphasizes the need to include outcomes other than price into managed mental health care contracts in the United States. Argument that critical resources of care will be eroded from mental health service delivery if price is the sole measure of quality; Need to develop practice guidelines and outcome measures in various sectors of the mental health care industry.
KW - MANAGED mental health care
KW - UNITED States
N1 - Accession Number: 560812; Manderscheid, Ronald W.; Manderscheid, R W 1; Source Information: May98, Vol. 25 Issue 2, p233; Subject: MANAGED mental health care; Geographic Terms: UNITED States; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107281855
T1 - Perspectives in practice. Olestra: a new food additive.
AU - Prince DM
AU - Welschenbach MA
Y1 - 1998/05//
N1 - Accession Number: 107281855. Language: English. Entry Date: 19980901. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Olestra
KW - United States Food and Drug Administration
KW - Fat Substitutes -- Adverse Effects
SP - 565
EP - 569
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 98
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Office of the Commissioner, Office of Special Investigations, HF-5, Room 15-44, US Food and Drug Administration, 5600 Fishers Ln, Rockville, MD 20857
U2 - PMID: 9597030.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107281855&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107278647
T1 - FDA public health notice. Potential hypersensitivity reactions to chlorhexidine-impregnated medical devices.
AU - Burlington B
Y1 - 1998/05//1998 May
N1 - Accession Number: 107278647. Language: English. Entry Date: 19980901. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8912029.
KW - Chlorhexidine -- Adverse Effects
KW - Hypersensitivity
KW - Equipment and Supplies -- Adverse Effects
KW - United States Food and Drug Administration
KW - Anaphylaxis -- Etiology
KW - Catheters, Vascular
KW - Bandages and Dressings
KW - Mandatory Reporting
SP - 84
EP - 88
JO - Ostomy Wound Management
JF - Ostomy Wound Management
JA - OSTOMY WOUND MANAGE
VL - 44
IS - 5
CY - Malvern, Pennsylvania
PB - HMP Communications
SN - 0889-5899
AD - Director, Center for Devices and Radiological Health
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288736
T1 - Should the Vaccine Injury Compensation Program be expanded to cover adults?
AU - Lloyd-Puryear MA
AU - Ball LK
AU - Benor D
Y1 - 1998/05//May/Jun98
N1 - Accession Number: 107288736. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Vaccines -- Adverse Effects -- In Adulthood
KW - Liability, Legal
KW - Government Programs
KW - Immunization Programs
KW - Influenza Vaccine -- In Adulthood
KW - Pneumococcal Vaccine -- In Adulthood
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
SP - 236
EP - 242
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 113
IS - 3
PB - Sage Publications Inc.
AB - In 1996, the National Vaccine Advisory Committee (NVAC) asked for a review of the pros and cons of including adult influenza and pneumococcal vaccines in the Vaccine Injury Compensation Program (VICP). The authors, as staff to the subcommittees charged with undertaking this assessment, looked at the following questions: (a) Would inclusion in VICP of these two vaccines, used primarily for adults, increase adult vaccination levels? (b) Is this Federal involvement warranted based on the liability burden for these vaccines? (c) Does the risk of adverse events following vaccinations warrant inclusion of these vaccines? (d) Is there a consensus among stakeholders favoring their inclusion? To address these questions, the authors reviewed information on adult vaccines, including data on lawsuits filed and reports of injuries, and sought input from interested groups. They found no evidence that the use of influenza and pneumococcal vaccines would increase if they were included in VICP. They found a low liability burden for these vaccines, that serious adverse events were rare, and that no consensus existed among stakeholders. After considering the staff report, NVAC chose, in 1996, not to advise the Department of Health and Human Services to include adult vaccines in VICP.
SN - 0033-3549
AD - Division of Vaccine Injury Compensation, Bureau of Health Professions, US Health Resources and Services Administration (HRSA)
U2 - PMID: 9633868.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288736&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107288763
T1 - The use of infrared ear thermometers in pediatric and family practice offices.
AU - Silverman BG
AU - Daley WR
AU - Rubin JD
Y1 - 1998/05//May/Jun98
N1 - Accession Number: 107288763. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Thermometers -- Utilization
KW - Practitioner's Office
KW - Thermometers -- Standards
KW - Descriptive Research
KW - Random Sample
KW - Questionnaires
KW - Telephone
KW - Data Analysis Software
KW - Chi Square Test
KW - Physician Attitudes
KW - Age Factors
KW - Infant, Newborn
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Human
SP - 268
EP - 272
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 113
IS - 3
PB - Sage Publications Inc.
AB - Objective. To describe the use of infrared (IR) ear thermometers in pediatric and family practice offices. Methods. The authors mailed a questionnaire to 350 randomly selected members of the American Academy of Pediatrics and to 355 randomly selected members of the American Academy of Family Physicians. Results. Of respondents in clinical practice, 78% had used IR ear thermometers at least once in the past; 65% of pediatricians and 64% of family practice physicians were current users. Seventeen percent of pediatric offices and 18% of family practice offices that had used IR ear thermometers had discontinued use, most citing inaccuracy or lack of staff trust in the device. Pediatric offices were less likely than family practice offices to use the device in well neonates and sick neonates and more likely to use it in sick children. Advantages cited included rapid readings, ease of use, and accuracy. Seventy-five percent of current users reported at least one problem, including low readings and lack of staff trust. Conclusions. IR ear thermometers are widely used in pediatric and family practice offices. Some offices limit use of these devices to older children and adults, and most of the offices surveyed report using other devices as a check on the accuracy of IR thermometers. Statements by professional organizations that provide user guidelines and establish appropriate age cutoffs would be helpful.
SN - 0033-3549
AD - FDA, Center for Devices and Radiological Health, HFZ-541, 1350 Piccard Dr., Rockville, MD 20850; e-mail: bgs@cdrh.fda.gov
U2 - PMID: 9633875.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107288763&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Nightingale, S. L.;
T1 - Advertising prescription-only drugs: 1
CT - Advertising prescription-only drugs: 1
JO - Lancet (England)
JF - Lancet (England)
Y1 - 1998/05/23/
VL - 351
IS - May 23
SP - 1582
SN - 00237507
AD - Dept. of Health and Human Services, Public Health Service, FDA, Rockville, MD 20857, USA
N1 - Accession Number: 35-13913; Language: English; References: 2; Publication Type: Letters; Journal Coden: LANCAO; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and EthicsInformation Processing and Literature; Abstract Author: Ramune T. Dailide
N2 - Information about the regulation of direct-to-consumer (DTC) advertising of prescription drugs by the U.S. Food and Drug Administration (FDA) is very briefly presented, and 2 World Wide Web citations for additional FDA information for manufacturers about DTC advertising are provided.
KW - Food and Drug Administration (U.S.)--regulations--direct to consumer advertising;
KW - Regulations--Food and Drug Administration--direct to consumer advertising;
KW - Advertising--prescription drugs--FDA regulations;
KW - Prescriptions--advertising--direct to consumer;
KW - World Wide Web--Food and Drug Administration--direct to consumer advertising;
KW - Internet--Food and Drug Administration--direct to consumer advertising;
KW - Computers--Food and Drug Administration--direct to consumer advertising;
KW - Industry, pharmaceutical--advertising--FDA regulations;
KW - Marketing--prescription drugs--direct to consumer advertising;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hollingdale, M.R.
AU - McCormick, C.J.
AU - Heal, K.G.
AU - Taylor-Robinson, A.W.
AU - Reeve, P.
AU - Boykins, R.
AU - Kazura, J.W.
T1 - Biology of malarial liver stages: implications for vaccine design.
JO - Annals of Tropical Medicine & Parasitology
JF - Annals of Tropical Medicine & Parasitology
Y1 - 1998/06//
VL - 92
IS - 4
M3 - Article
SP - 411
PB - Taylor & Francis Ltd
SN - 00034983
AB - The molecular events controlling sporozoite invasion and exo-erythrocytic (EE) development within hepatocytes are largely not understood, and EE parasites are probably better defined immunologically than biologically. The observation that the Plasmodium falciparum sporozoite antigen TRAP (thrombospondinrelated anonymous protein) contains multiple adhesive domains that recognize endothelial and hepatocyte receptors indicates that, like leucocyte passage across capillaries, sporozoite invasion probably involves a co-ordinated interaction between sporozoite and hepatic molecules. The parallel with leucocyte extravasation is strengthened by the finding that TRAP contains a functional, integrin-like, I domain. EE parasites are an important target of immunity elicited by irradiated sporozoites, and much current effort is focused on developing malaria vaccines targeting EE parasites. Only one EE-specific antigen, liver-stage antigen 1 (LSA-1), is known to be expressed during EE development and may contribute to protective immunity elicited by irradiated P. falciparum sporozoites. In a study in Papua New Guinea, resistance to P. falciparum infection correlated with CD8+ T-cell interferon-gamma responses to an LSA-1 epitope that contains an HLA A11-restricted sequence. Since A11 is 40% frequent in this population it is reasonable to suggest that, as with B53 responses to LSA-1 in The Gambia, P. falciparum has driven genetic selection of certain HLA haplotypes, as proposed by Haldane nearly 50 years ago. LSA-1 is thus an important vaccine candidate, and is being expressed in bacterial and phage vectors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Medicine & Parasitology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Apicomplexa
KW - Liver cells
KW - Molecules
KW - Proteins
N1 - Accession Number: 7620671; Hollingdale, M.R. 1; Email Address: m.r.hollingdale@leeds.ac.uk; McCormick, C.J. 1; Heal, K.G. 1; Taylor-Robinson, A.W. 1; Reeve, P. 2; Boykins, R. 2; Kazura, J.W. 3; Affiliations: 1: School of Biology, University of Leeds, Leeds LS2 9JT, U.K.; 2: Centers for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20853, U.S.A.; 3: Division of Geographic Medicine, Case Western Reserve University, Cleveland, OH 44106, U.S.A.; Issue Info: Jun1998, Vol. 92 Issue 4, p411; Thesaurus Term: Apicomplexa; Subject Term: Liver cells; Subject Term: Molecules; Subject Term: Proteins; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/00034989859393
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=7620671&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Quinn, J.;
AU - Panasethaned, K.;
AU - O'Brien, P.;
AU - Subramaniam, V.;
AU - Binghay, M. C.;
T1 - Washington Metropolitan Society of Hospital Pharmacists initiative: use of communications technology
CT - Washington Metropolitan Society of Hospital Pharmacists initiative: use of communications technology
JO - ASHP Annual Meeting
JF - ASHP Annual Meeting
Y1 - 1998/06/01/
VL - 55
IS - Jun
SP - ASC
EP - C-3
AD - Food and Drug Administration Center for Drug Evaluation and Research, Office of Information Technology, 5600 Fishers Lane, Room 8B-45, HFD-72, Rockville, MD 20857, USA Internet: quinnj@cder.fda.gov
N1 - Accession Number: 35-05330; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice
N2 - The Washington Metropolitan Society of Hospital Pharmacists (WMSHP) has embarked on an initial strategy identifying opportunities to increase communication with its membership. The initiative describes new programs using the World Wide Web, desktop publishing, and use of electronic mailing for communication with members. Member satisfaction was measured from results of membership accessing the WMSHP web site, membership seminar participation, survey questionnaires, and use of e-mail for responses. This initiative seeks to implement efficient ways to enable busy pharmacist practitioners to use technology in their institutions to communicate with WMSHP as part of its educational and professional objectives. Limitations in the use of communication technology were also studied.
KW - ASHP meeting abstracts--Washington Metropolitan Society of Hospital Pharmacists;
KW - Organizations--Washington Metropolitan Society of Hospital Pharmacists--membership communication;
KW - Administration--Washington Metropolitan Society of Hospital Pharmacists--membership communication;
KW - Washington Metropolitan Society of Hospital Pharmacists--membership--communication;
KW - Membership--Washington Metropolitan Society of Hospital Pharmacists--communication;
KW - Communication--Washington Metropolitan Society of Hospital Pharmacists--membership;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107284982
T1 - Type 2 diabetes in people of color.
AU - Hosey G
AU - Gordon S
AU - Levine A
Y1 - 1998/06//1998 Jun
N1 - Accession Number: 107284982. Language: English. Entry Date: 19981001. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9100939.
KW - Diabetes Mellitus, Type 2
KW - Blacks
KW - Native Americans
KW - Hispanics
KW - Race Factors
KW - Diabetes Mellitus, Type 2 -- Epidemiology
KW - Cultural Competence
KW - Risk Factors
KW - Diabetes Education
KW - Nurse Practitioners
KW - Transcultural Nursing
SP - 108
EP - 114
JO - Nurse Practitioner Forum
JF - Nurse Practitioner Forum
JA - NURSE PRACT FORUM
VL - 9
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Type 2 diabetes is a major public health concern for people of color throughout the United States. The prevalence of type 2 diabetes among African-Americans, Hispanics and American Indian/Alaskan Natives is from two to six times greater than that of the US non-Hispanic white population. Rates of end-stage renal disease, amputations, and diabetic retinopathy are also significantly higher. The medical risk factors of familial history, insulin resistance, obesity, history of gestational diabetes, impaired glucose tolerance, and physical inactivity are the same for all populations. The disproportionate impact of diabetes in people of color may be because of an interaction of genetic risk factors and environmental factors. Recognizing the impact of culture in disease management and self-care practices can improve diabetes care. This is a US government work. There are no restrictions on its use.
SN - 1045-5485
AD - Diabetes Consultant, Portland Area Indian Health Service Diabetes Program, Bellingham, WA
U2 - PMID: 9752126.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107275322
T1 - Device errors. Enteral feeding tubes.
AU - Reid M
Y1 - 1998/06//
N1 - Accession Number: 107275322. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Feeding Tubes -- Nursing
KW - Feeding Tubes -- Adverse Effects
KW - Aged
KW - Male
KW - Inpatients
SP - 25
EP - 25
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Check carefully to avoid misconnecting these devices.
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9668786.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fein, Sara B.
AU - Roe, Brian
T1 - The Effect of Work Status on Initiation and Duration of Breast-Feeding.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/07//
VL - 88
IS - 7
M3 - Article
SP - 1042
EP - 1042
PB - American Public Health Association
SN - 00900036
AB - Objectives. In this study, longitudinal data are used to examine the effect of work status on breast-feeding initiation and duration. Methods. Mothers from a mail panel completed questionnaires during late pregnancy and 10 times in the infant's first year. Mother's work status was categorized for initiation by hours she expected, before delivery, to work and for duration by hours she worked at month 3. Covariates were demographics; parity; medical, delivery, and hospital experiences; social support; embarrassment; and health promotion. Results. Expecting to work part-time neither decreased nor increased the probability of breast-feeding relative to expecting not to work (odds ratios [ORs] = .83 and .89, P > .50), but expecting to work full-time decreased the probability of breast-feeding (OR = .47, P < .01). Working full-time at 3 months postpartum decreased breast-feeding duration by an average of 8.6 weeks (P < .001) relative to not working, but part-time work of 4 or fewer hours per day did not affect duration, and part-time work of more than 4 hours per day decreased duration less than full-time work. Conclusion. Part-time work is an effective strategy to help mothers combine breast-feeding and employment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Breastfeeding (Humans)
KW - Working mothers
KW - Infant nutrition
KW - Mother & infant
KW - Women employees
N1 - Accession Number: 817316; Fein, Sara B. 1; Email Address: sbf@cfsan.fda.gov; Roe, Brian 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC; Issue Info: Jul98, Vol. 88 Issue 7, p1042; Subject Term: Breastfeeding (Humans); Subject Term: Working mothers; Subject Term: Infant nutrition; Subject Term: Mother & infant; Subject Term: Women employees; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 4072
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107277837
T1 - Editorial: are you certain? -- uncertainty, health, and safety in contemporary work.
AU - Hurrell JJ Jr.
Y1 - 1998/07//
N1 - Accession Number: 107277837. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Occupational Health
KW - Employment Status -- Psychosocial Factors
KW - Uncertainty
KW - Downsizing, Organizational
KW - Stress, Occupational
KW - Work Environment -- Psychosocial Factors
KW - Job Security
SP - 1012
EP - 1013
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 7
CY - Washington, District of Columbia
PB - American Public Health Association
SN - 0090-0036
AD - Division of Surveillance, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 9663142.
DO - 10.2105/AJPH.88.7.1012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107277837&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107277852
T1 - The effect of work status on initiation and duration of breast-feeding.
AU - Fein SB
AU - Roe B
Y1 - 1998/07//
N1 - Accession Number: 107277852. Language: English. Entry Date: 19980801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Employment Status
KW - Breast Feeding
KW - Maternal Attitudes
KW - Prospective Studies
KW - Questionnaires
KW - Mail
KW - Data Analysis Software
KW - Odds Ratio
KW - Logistic Regression
KW - Descriptive Statistics
KW - Chi Square Test
KW - P-Value
KW - Time Factors
KW - Part Time Employment
KW - Parity
KW - Family and Medical Leave
KW - T-Tests
KW - Pregnancy
KW - Female
KW - Human
SP - 1042
EP - 1046
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 7
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: In this study, longitudinal data are used to examine the effect of work status on breast-feeding initiation and duration. METHODS: Mothers from a mail panel completed questionnaires during late pregnancy and 10 times in the infant's first year. Mother's work status was categorized for initiation by hours she expected, before delivery, to work and for duration by hours she worked at month 3. Covariates were demographics; parity; medical, delivery, and hospital experiences; social support; embarrassment; and health promotion. RESULTS: Expecting to work part-time neither decreased nor increased the probability of breast-feeding relative to expecting not to work (odds ratios [ORs] = .83 and .89, P > .50), but expecting to work full-time decreased the probability of breast-feeding (OR = .47, P < .01). Working full-time at 3 months postpartum decreased breast-feeding duration by an average of 8.6 weeks (P < .001) relative to not working, but part-time work of 4 or fewer hours per day did not affect duration, and part-time work of more than 4 hours per day decreased duration less than full-time work. CONCLUSION: Part-time work is an effective strategy to help mothers combine breast-feeding and employment.
SN - 0090-0036
AD - Center for Food Safety and Applied Nutrition, HFS-727, 200 C St SW, Washington, DC 20204. E-mail: sbf@cfsan.fda.gov
U2 - PMID: 9663151.
DO - 10.2105/AJPH.88.7.1042
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107281820
T1 - From the Food and Drug Administration. MedWatch program... first in a series of regular articles.
AU - White GG
Y1 - 1998/07//1998 Jul-Sep
N1 - Accession Number: 107281820. Language: English. Entry Date: 19980901. Revision Date: 20150711. Publication Type: Journal Article; forms; tables/charts; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Voluntary Reporting
KW - Drugs -- Adverse Effects
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 100
EP - 103
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 4
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - MedWatch, Food and Drug Administration, Room 1765, HF-2, 5600 Fishers La., Rockville, MD 20857
U2 - PMID: 9855977.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107281820&site=ehost-live&scope=site
UR - Related websites: www.fda.gov/
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107300317
T1 - Consumers' ability to perform tasks using nutrition labels.
AU - Levy AS
AU - Fein SB
Y1 - 1998/07//Jul/Aug98
N1 - Accession Number: 107300317. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. NLM UID: 0246004.
KW - Nutrition
KW - Food Labeling
KW - Consumers
KW - Knowledge -- Evaluation
KW - Experimental Studies
KW - Interviews
KW - Regression
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 210
EP - 217
JO - Journal of Nutrition Education
JF - Journal of Nutrition Education
JA - J NUTR EDUC
VL - 30
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0022-3182
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107280993
T1 - Device errors. Infant skin temperature probes: follow these safety tips for use.
AU - Woo EK
Y1 - 1998/07//
N1 - Accession Number: 107280993. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Body Temperature Determination -- Equipment and Supplies -- In Infancy and Childhood
KW - Burns -- Prevention and Control -- In Infancy and Childhood
KW - Skin
KW - Equipment Safety
KW - Infant, Newborn
SP - 31
EP - 31
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9687673.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shields, Peter G.
AU - Ambrosone, Christine B.
T1 - Smoking and Breast Cncer.
JO - Scientific American Presents
JF - Scientific American Presents
Y1 - 1998/07//
M3 - Article
SP - 86
EP - 89
PB - Scientific American
SN - 15240223
AB - The article focuses on the link between smoking and breast cancer. Researchers believe that one important and preventable risk factor for breast cancer is cigarette smoking. New studies suggest that roughly half of all women are particularly sensitive to the carcinogens found in tobacco and so have a higher risk of breast cancer if they smoke cigarettes. Such women have a slow-acting form of a liver enzyme that normally detoxifies carcinogens. Because these women's "detox" enzymes act more slowly than the enzymes of other women, the carcinogens in tobacco last longer in their bodies, allowing the substances more time to cause cancer. INSET: Lung Cancer: Why Women's Risks Are Higher.
KW - BREAST cancer
KW - SMOKING
KW - CIGARETTE smokers
KW - CARCINOGENS
KW - CANCER in women
KW - WOMEN -- Health
N1 - Accession Number: 20921316; Shields, Peter G. 1; Ambrosone, Christine B. 2; Affiliations: 1: Chief of the Molecular Epidemiology Section in the Laboratory of Human Carcinogenesis at the National Cancer Institute; 2: Research epidemiologist in the Division of Molecular Epidemiology at the Food and Drug Administration's National Center for Toxicological Research in Jefferson, Ark; Issue Info: 1998, p86; Subject Term: BREAST cancer; Subject Term: SMOKING; Subject Term: CIGARETTE smokers; Subject Term: CARCINOGENS; Subject Term: CANCER in women; Subject Term: WOMEN -- Health; Number of Pages: 4p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 2774
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gutman, Steven
AU - Richter, Kimber
AU - Alpert, Susan
AU - Gutman, S
AU - Richter, K
AU - Alpert, S
T1 - Update on FDA regulation of in vitro diagnostic devices.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1998/07/08/
VL - 280
IS - 2
M3 - journal article
SP - 190
EP - 192
SN - 00987484
AB - Provides an update on the United States Food & Drug Administration's (FDA) regulation of in vitro diagnostic devices (IVD). Establishment of the FDA's regulation of diagnostic devices under the Medical Device Amendments of 1976; The goal of device reviews; How IVDs are subject to specific labeling regulations; How the FDA established regulations for good manufacturing practices of diagnostic devices in 1987.
KW - MEDICAL equipment -- Government policy
KW - UNITED States. Food & Drug Administration
KW - CONSTITUTIONAL amendments
KW - DIAGNOSTIC equipment industry
KW - UNITED States
N1 - Accession Number: 805098; Gutman, Steven; Richter, Kimber; Alpert, Susan; Gutman, S 1; Richter, K; Alpert, S; Source Information: 7/8/98, Vol. 280 Issue 2, p190; Subject: MEDICAL equipment -- Government policy; Subject: UNITED States. Food & Drug Administration; Subject: CONSTITUTIONAL amendments; Subject: DIAGNOSTIC equipment industry; Geographic Terms: UNITED States; Number of Pages: 3p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107170323
T1 - Iron and zinc interactions in humans...Zinc for child health. Proceedings of a symposium held in Baltimore, Maryland, November 17-19, 1996
AU - Whittaker P
Y1 - 1998/08//
N1 - Accession Number: 107170323. Language: English. Entry Date: 19990101. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Iron -- Metabolism
KW - Zinc -- Metabolism
KW - Absorption
KW - Food, Fortified
KW - Iron -- Administration and Dosage
KW - Zinc -- Administration and Dosage
SP - 442S
EP - 6S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 68
IS - 2
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - Iron deficiency is the most common nutritional deficiency in the world; zinc deficiency is associated with poor growth and development and impaired immune response. Several Third World countries are taking measures to increase the dietary intake of iron and zinc with fortification of foods or dietary supplements. Several studies showed that high iron concentrations can negatively affect zinc absorption in adults when these trace minerals are given in solution. However, when iron and zinc are given in a meal, this effect is not observed. Solomons (J Nutr 1986;116:927-35) postulated that the total amount of ionic species affects the absorption of zinc and that a total dose of >25 mg Fe may produce a measurable effect on zinc absorption. This could occur if iron supplements are taken with a meal, and iron experts recommend that iron supplements be taken between meals. Recent studies using stable isotopes showed that fortifying foods with iron at current fortification amounts has no adverse effect on zinc absorption. There are 5 zinc salts listed as generally recommended as safe (GRAS) by the US Food and Drug Administration for food fortification. From 1970 to 1987, the total amount of zinc salts used in food continually increased, with zinc oxide and zinc sulfate showing the largest increases. Twelve iron sources are listed as GRAS; elemental iron has become the source of choice because it is less expensive to produce and has fewer organoleptic problems. Use of ferrous fumarate is also increasing. Copyright (c) 1998 American Society for Clinical Nutrition
SN - 0002-9165
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C St,SW Washington, DC 20204; e-mail: pvw@cfsan.fda.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Headrick, Marci L.
AU - Korangy, Shahin
AU - Bean, Nancy H.
AU - Angulo, Frederick J.
AU - Altekruse, Sean F.
AU - Potter, Morris E.
AU - Klontz, Karl C.
T1 - The Epidemiology of Raw Milk--Associated Foodborne Disease Outbreaks Reported in the United States, 1973 Through 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/08//
VL - 88
IS - 8
M3 - Article
SP - 1219
EP - 1221
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study describes the epidemiology of raw milk-associated outbreaks reported to the Centers for Disease Control and Prevention from 1973 through 1992. Methods. Surveillance data for each reported raw milk-associated outbreak were reviewed. A national survey was conducted to determine the legal status of intrastate raw milk sales for the period 1973 through 1995. Results. Forty-six raw milk-associated outbreaks were reported during the study period; 40 outbreaks (87%) occurred in states where the intrastate sale of raw milk was legal. Conclusions. Consumption of raw milk remains a preventable cause of foodborne disease outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Milk
KW - Communicable diseases -- Transmission
KW - Epidemiology
KW - Foodborne diseases
KW - Raw milk
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 936471; Headrick, Marci L. 1; Korangy, Shahin 1; Bean, Nancy H. 2; Angulo, Frederick J. 2; Altekruse, Sean F. 3; Potter, Morris E. 2; Klontz, Karl C. 1; Affiliations: 1: Epidemiology Branch, Center for Food Safety and Applied Nutrition, Washington, DC; 2: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Atlanta, Ga; 3: Food and Drug Administration liaison to the National Center for Infectious Diseases; Issue Info: Aug1998, Vol. 88 Issue 8, p1219; Thesaurus Term: Milk; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Epidemiology; Thesaurus Term: Foodborne diseases; Subject Term: Raw milk ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 3p; Illustrations: 1 Chart, 1 Map; Document Type: Article; Full Text Word Count: 1869
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107303566
T1 - The epidemiology of raw milk-associated foodborne disease outbreaks reported in the United States, 1973 through 1992.
AU - Headrick ML
AU - Korangy S
AU - Bean NH
AU - Angulo FJ
AU - Altekruse SF
AU - Potter ME
AU - Klontz KC
Y1 - 1998/08//
N1 - Accession Number: 107303566. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Milk -- Adverse Effects
KW - Disease Outbreaks -- Epidemiology
KW - Food Microbiology
KW - Food Contamination -- Epidemiology
KW - United States
KW - Epidemiological Research
KW - Disease Surveillance
KW - Descriptive Research
KW - Descriptive Statistics
KW - Disease Outbreaks -- Prevention and Control
KW - Milk -- Legislation and Jurisprudence -- United States
KW - Government Regulations
KW - Human
SP - 1219
EP - 1221
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study describes the epidemiology of raw milk-associated outbreaks reported to the Centers for Disease Control and Prevention from 1973 through 1992. METHODS: Surveillance data for each reported raw milk-associated outbreak were reviewed. A national survey was conducted to determine the legal status of intrastate raw milk sales for the period 1973 through 1995. RESULTS: Forty-six raw milk-associated outbreaks were reported during the study period; 40 outbreaks (87%) occurred in states where the intrastate sale of raw milk was legal. CONCLUSIONS: Consumption of raw milk remains a preventable cause of foodborne disease outbreaks.
SN - 0090-0036
AD - Epidemiology Branch, Center for Food Safety and Applied Nutrition, Washington, DC
U2 - PMID: 9702153.
DO - 10.2105/AJPH.88.8.1219
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107303566&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Turturro, A.
AU - Hass, B.
AU - Hart, R.W.
T1 - Hormesis – Implications for risk assessment caloric intake (body weight) as an exemplar.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 1998/08//
VL - 17
IS - 8
M3 - Article
SP - 454
EP - 459
PB - Sage Publications, Ltd.
SN - 09603271
AB - Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter into risk assessments for toxicants. Based on the work with caloric intake, one could: (a) define a biomarker for hormetic effect; (b) integrate specific information on when in the animals lifespan the parameter is active to influence parameters such as survival; (c) evaluate component effects of the overall hormetic response; and (d) address the consequences of a non-monotonic relationship between the hormetic parameter and endpoints critical for risk assessment. These impacts on risk assessments have been characterized for chronic tests, but are also true for short-term tests. A priority is the characterization of the dose-response curves for hormetic parameters. This quantification will be critical in utilizing them in risk assessment. With this information, one could better quantitatively address the changes one expects to result from the hormetic parameter, and limit the uncertainty and variability which occurs in toxicity testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Nutrition
KW - Health
KW - Hormesis
KW - bioassay
KW - body weight
KW - caloric intake
KW - dietary control
KW - hormesis
KW - Non-monotonic
N1 - Accession Number: 4664061; Turturro, A. 1; Hass, B. 2; Hart, R.W. 3; Affiliations: 1: National Center for Toxicological Research, Division of Biometry and Risk Assessment, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA; 2: National Center for Toxicological Research, Division of Genetic Toxicology, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA; 3: National Center for Toxicological Research, Office of the Director, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA; Issue Info: 1998, Vol. 17 Issue 8, p454; Thesaurus Term: Risk assessment; Thesaurus Term: Nutrition; Thesaurus Term: Health; Subject Term: Hormesis; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: body weight; Author-Supplied Keyword: caloric intake; Author-Supplied Keyword: dietary control; Author-Supplied Keyword: hormesis; Author-Supplied Keyword: Non-monotonic; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rith-Najarian, Stephen
AU - Branchaud, Charmaine
AU - Beaulieu, Oran
AU - Gohdes, Dorothy
AU - Simonson, Gregg
AU - Mazze, Roger
T1 - Reducing Lower-Extremity Amputations Due to Diabetes.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1998/08//
VL - 47
IS - 2
M3 - Article
SP - 127
EP - 132
SN - 00943509
AB - BACKGROUND. While Lower-extremity amputation (LEA) is a frequent complication of diabetes, effective strategies for the prevention of LEA in primary care settings have not been extensively studied. METHODS. This prospective study of American Indians with diabetes in a rural primary care clinic was divided into three periods: the standard care period (1986 to 1989), during which patients received foot care at the discretion of the primary care provider; the public health period (1990 to 1993), during which patients were screened for foot problems and high-risk individuals received foot care education and protective footwear; and the Staged Diabetes Management (SDM) period (1994 to 1996), during which comprehensive guidelines for diabetic foot management were adapted by the primary care clinicians to their practices and were systematically implemented. RESULTS. A total of 639 individuals contributed 4322 diabetic person-years during the three periods of observation. Patient sex distribution, mean age, and mean duration of diabetes were similar in the three periods. The average annual LEA incidence was 29/1000 diabetic person-years for the standard care period (n=42), 21/1000 for the public health period (n=33), and 15/1000 for the SDM period (n=20), an overall 48% reduction (P = .016). Overall, the incidence of a first amputation declined from 21/1000 to 6/1000 (P < .001). CONCLUSIONS. The customization and systematic implementation of practice guidelines by local primary care providers was associated with improved diabetic foot care outcomes. SDM has relevance to primary care organizations seeking to improve outcomes for patients with diabetes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPUTATION
KW - DIABETES -- Complications
KW - PRIMARY care (Medicine)
KW - NATIVE Americans
KW - SEX distribution (Demography)
KW - MEDICAL care
KW - amputation
KW - Diabetes
KW - Indians
KW - Indians, North American
KW - lower extremity
KW - North American
KW - primary care
N1 - Accession Number: 996875; Rith-Najarian, Stephen 1; Email Address: srithnajarian@nchs.com; Branchaud, Charmaine 2; Beaulieu, Oran; Gohdes, Dorothy 3; Simonson, Gregg 4; Mazze, Roger 4; Source Information: Aug1998, Vol. 47 Issue 2, p127; Subject: AMPUTATION; Subject: DIABETES -- Complications; Subject: PRIMARY care (Medicine); Subject: NATIVE Americans; Subject: SEX distribution (Demography); Subject: MEDICAL care; Author-Supplied Keyword: amputation; Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: Indians; Author-Supplied Keyword: Indians, North American; Author-Supplied Keyword: lower extremity; Author-Supplied Keyword: North American; Author-Supplied Keyword: primary care; Number of Pages: 6p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107301918
T1 - Health service applications. Tuberculosis transmission in a high school choir.
AU - Washko R
AU - Robinson E
AU - Fehrs LJ
AU - Frieden TR
Y1 - 1998/08//
N1 - Accession Number: 107301918. Language: English. Entry Date: 19981201. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0376370.
KW - Tuberculosis, Pulmonary -- Transmission
KW - Tuberculosis, Pulmonary -- Epidemiology -- New York
KW - Disease Outbreaks -- New York
KW - Students, High School
KW - Epidemiological Research
KW - Environmental Exposure
KW - Singing
KW - Questionnaires
KW - Tuberculin Test
KW - Microbial Culture and Sensitivity Tests
KW - Vaccine Failure
KW - Data Analysis, Statistical
KW - Immigrants
KW - Sex Factors
KW - Race Factors
KW - Age Factors
KW - Male
KW - Female
KW - Asians
KW - Blacks
KW - Whites
KW - Hispanics
KW - Adolescence
KW - Schools, Secondary -- New York
KW - New York
SP - 256
EP - 259
JO - Journal of School Health
JF - Journal of School Health
JA - J SCH HEALTH
VL - 68
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0022-4391
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Clinical Investigations Branch, 1095 Willowdale Road, Room H-009, Morgantown, WV 26505; e-mail: RMW8@CDC.GOV
U2 - PMID: 9720000.
DO - 10.1111/j.1746-1561.1998.tb06351.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107157019
T1 - Observations from the CDC. Women and work: highlights of NIOSH research.
AU - Tisdale JA
AU - Sofge CW
Y1 - 1998/08//
N1 - Accession Number: 107157019. Language: English. Entry Date: 19990101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9208978.
KW - Occupational Health
KW - Women's Health
KW - United States
KW - National Institute for Occupational Safety and Health
KW - Work Environment
KW - Research -- Trends
KW - Female -- United States
SP - 651
EP - 654
JO - Journal of Women's Health
JF - Journal of Women's Health
JA - J WOMENS HEALTH
VL - 7
IS - 6
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1059-7115
AD - National Institute for Occupational Safety and Health, 200 Independence Avenue, SW, 715-H, Washington, DC 20201
U2 - PMID: 9718533.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107157019&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tisdale, Julie A.
AU - Sofge, Christine W.
T1 - Women and Work: Highlights of NIOSH Research.
JO - Journal of Women's Health
JF - Journal of Women's Health
Y1 - 1998/08//
VL - 7
IS - 6
M3 - Article
SP - 651
PB - Mary Ann Liebert, Inc.
SN - 10597115
AB - The article focuses on the works of the National Institute for Occupational Safety and Health (NIOSH) in the U.S. NIOSH is a part of the Centers for Disease Control and Prevention, and is the federal agency responsible for conducting research and making recommendations for the prevention of work-related disease and injury. NIOSH is mandated by Congress to "assure safe and healthful working conditions for working men and women." It is important to understand and appreciate the connection between human health and workplace hazards. Although often overlooked, the workplace can have a profound impact on a worker's health, ranging from cancer in factory workers to carpal tunnel syndrome in computer users. Although NIOSH research and prevention efforts protect all workers, the Institute recognizes that women often face unique risks such as chemical and physical exposures that affect pregnancy or the menstrual cycle or hazards encountered using equipment designed for male workers of larger stature. In addition to protecting workingwomen, studying workers can improve the health of the general population.
KW - NATIONAL Institute for Occupational Safety & Health
KW - INDUSTRIAL safety
KW - INDUSTRIAL hygiene
KW - WORK environment
KW - EMPLOYEE health promotion
KW - UNITED States
N1 - Accession Number: 5878879; Tisdale, Julie A. 1; Sofge, Christine W.; Source Information: Aug98, Vol. 7 Issue 6, p651; Subject: NATIONAL Institute for Occupational Safety & Health; Subject: INDUSTRIAL safety; Subject: INDUSTRIAL hygiene; Subject: WORK environment; Subject: EMPLOYEE health promotion; Geographic Terms: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107282002
T1 - Device errors. Biliblanket phototherapy light.
AU - Woo EK
Y1 - 1998/08//
N1 - Accession Number: 107282002. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Hyperbilirubinemia -- Therapy
KW - Jaundice, Neonatal -- Therapy
KW - Phototherapy -- Equipment and Supplies -- In Infancy and Childhood
KW - Equipment Safety
KW - Patient Safety
KW - Infant, Newborn
KW - Inpatients
SP - 79
EP - 79
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9739265.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107282002&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107174089
T1 - New investigators. Effects of contracting and local markets on costs of public mental health services in California.
AU - Libby AM
AU - Wallace NT
Y1 - 1998/08//
N1 - Accession Number: 107174089. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Herfindahl-Hirschman Index (HHI). Grant Information: Supported by training grant 5-T32-MH18828 from the National Institute of Mental Health, and NIMH grant P50-MH43694 to the Center for Mental Health Services Research in Berkeley, California. NLM UID: 9502838.
KW - Contract Services -- Economics
KW - Mental Health Services -- Economics
KW - Research Instruments
KW - California
KW - Cost Savings
KW - Costs and Cost Analysis
KW - Managed Care Programs -- Economics
KW - P-Value
KW - Regression
KW - Funding Source
KW - Human
SP - 1067
EP - 1071
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 49
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: This study examined the factors that determine whether mental health services provided under contracts with private providers are more cost-efficient than services provided directly by public mental health agencies. METHODS: Data on service costs for 1993 were obtained from the California Department of Mental Health cost reporting and data collection system and from a survey of local mental health departments. Ordinary least-squares regression was used to estimate the effect of contracting, local market conditions, and contracting procedures on unit costs of seven core mental health services: psychiatric inpatient care, rehabilitative day service, intensive day service, individual therapy, medication management, crisis intervention, and case management. RESULTS: Contracts with private providers significantly reduced costs for six core mental health services, but not for inpatient care. However, the extent of savings was affected by local market conditions, including the concentration of providers in an area, the provider organization's size, and the scope of services that the provider offered, as well as by contracting procedures-whether there was a formal contract review process and whether prices were negotiated with the majority of providers. CONCLUSIONS: The amount of cost savings that can be achieved from contracting with private providers is influenced by several factors, including competitive conditions in local markets. In some areas, direct provision of services by public mental health agencies may cost less. Contracting is a complex process that cannot be viewed as a panacea for improving cost-efficiency.
SN - 1075-2730
AD - Center for Mental Health Services Research, University of California, Berkeley, 2020 Milvia Street, Suite 405, Room 5610, Berkeley, CA 94720-5610. E-mail: amlibby@socrates.berkeley.edu
U2 - PMID: 9712214.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107162966
T1 - Universal newborn hearing screening: a national goal.
AU - Strickland B
AU - McPherson M
Y1 - 1998/08//
N1 - Accession Number: 107162966. Language: English. Entry Date: 19990201. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8413380.
KW - Hearing Screening -- Trends -- In Infancy and Childhood
KW - Neonatal Assessment -- Trends
KW - Program Implementation
KW - Infant, Newborn
KW - Education, Continuing (Credit)
KW - Program Development
KW - Community Role
SP - 301
EP - 316
JO - Seminars in Hearing
JF - Seminars in Hearing
JA - SEMIN HEAR
VL - 19
IS - 3
CY - New York, New York
PB - Thieme Medical Publishing Inc.
SN - 0734-0451
AD - Division of Services for Children with Special Health Care Needs, Maternal and Child Health Bureau, Room 18-A-020 Parklawn Bldg, 5600 Fishers Lane, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107217608
T1 - A novel source of carbon monoxide poisoning: explosives used in construction.
AU - Deitchman S
AU - Decker J
AU - Santis L
Y1 - 1998/09//1998 Sep
N1 - Accession Number: 107217608. Language: English. Entry Date: 19991001. Revision Date: 20150818. Publication Type: Journal Article; case study. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646.
KW - Carbon Monoxide Poisoning -- Etiology
KW - Occupational Diseases
KW - Accidents, Occupational -- Prevention and Control
KW - Air Pollutants, Occupational
KW - Adult
KW - Male
SP - 381
EP - 384
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
JA - ANN EMERG MED
VL - 32
IS - 3 part 1
CY - New York, New York
PB - Elsevier Science
SN - 0196-0644
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Rd NE D40, Atlanta, GA 30333; e-mail: sed2@cdc.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Liao, W.
AU - Chiu, K.
AU - Mabuni, C.
AU - Soliman, M.
T1 - Analysis of Sennosides A and B from Dieter's Tea by HPLC-Diode Array Spectrophotometry and Negative Ion Electrospray Mass Spectrometry.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1998/09//
VL - 61
IS - 3
M3 - Article
SP - 317
EP - 324
SN - 00074861
AB - The article focuses on the study concerning the use of high performance liquid chromatography (HPLC)-diode array spectrophotometry and negative ion electrospray mass spectrometry (LC/MS) for the analysis of sennosides A and B from dieters' tea in Los Angeles, California. The combination of HPLC and LC/MS provides unambiguous fingerprint information for chemical structural confirmation of the compounds. Analysis of the results indicates that determination of sennosides was made by electrospray ionization mass spectrometry in the negative mode. The method is also valuable for the analysis of other sennoside compounds including C, D and F, and their derivatives.
KW - Toxicity testing
KW - Spectrometry
KW - Liquid chromatography
KW - Food -- Toxicology
KW - High performance liquid chromatography
KW - Electrospray ionization mass spectrometry
KW - Spectrophotometry
KW - Chemical structure
KW - Los Angeles (Calif.)
KW - California
N1 - Accession Number: 15730847; Liao, W. 1; Chiu, K. 2; Mabuni, C. 1; Soliman, M. 1; Affiliations: 1: California Department of Health Services, Division of Food, Drug and Radiation Safety, Food and Drug Laboratory Branch, 1521 West Pico Boulevard, Los Angeles, CA 90015, USA; 2: U.S. Food and Drug Administration, Los Angeles District Laboratory, Los Angeles, CA 90015, USA; Issue Info: Sep98, Vol. 61 Issue 3, p317; Thesaurus Term: Toxicity testing; Thesaurus Term: Spectrometry; Thesaurus Term: Liquid chromatography; Thesaurus Term: Food -- Toxicology; Subject Term: High performance liquid chromatography; Subject Term: Electrospray ionization mass spectrometry; Subject Term: Spectrophotometry; Subject Term: Chemical structure; Subject: Los Angeles (Calif.); Subject: California; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107180516
T1 - Molecular epidemiology of epithelial tumors.
AU - Ambrosone C
AU - Thompson P
Y1 - 1998/09//1998 Sep
N1 - Accession Number: 107180516. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007265.
KW - Neoplasms -- Etiology
KW - Risk Factors
SP - 467
EP - 474
JO - Current Opinion in Oncology
JF - Current Opinion in Oncology
JA - CURR OPIN ONCOL
VL - 10
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1040-8746
AD - Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079
U2 - PMID: 9800119.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107180516&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107155507
T1 - Eliminating health disparities for vulnerable populations through health education interventions within health services programs.
AU - Montes JH
AU - Johnston LL
Y1 - 1998/09//1998 Sep-Oct
N1 - Accession Number: 107155507. Language: English. Entry Date: 19990101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137.
KW - Health Education
KW - Vulnerability
KW - Health Services
KW - United States Department of Health and Human Services
KW - Primary Health Care
KW - School Health
KW - Acquired Immunodeficiency Syndrome
KW - Education, Non-Traditional
KW - Cultural Competence
SP - S6
EP - 9
JO - Journal of Health Education
JF - Journal of Health Education
JA - J HEALTH EDUC
VL - 29
IS - 5
CY - Reston, Virginia
PB - American Alliance for Health, Physical Education, Recreation & Dance
SN - 1055-6699
AD - Director, Division of Associates, Dental, and Public health Professions, Bureau of Health Professions, Health Resources and Services Administration (HRSA), Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107155511
T1 - Evaluating the elimination of disparities: issues and approaches to health status and outcomes assessment.
AU - Wells BL
AU - Conviser R
Y1 - 1998/09//1998 Sep-Oct
N1 - Accession Number: 107155511. Language: English. Entry Date: 19990101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137.
KW - Health Status
KW - Primary Health Care
KW - Outcomes Research
KW - United States Department of Health and Human Services
KW - Acquired Immunodeficiency Syndrome
KW - Medically Underserved
KW - United States
SP - S16
EP - 22
JO - Journal of Health Education
JF - Journal of Health Education
JA - J HEALTH EDUC
VL - 29
IS - 5
CY - Reston, Virginia
PB - American Alliance for Health, Physical Education, Recreation & Dance
AB - Most HRSA evaluation activities are funded through the 1-percent evaluation set aside authority, and these evaluations receive the most scrutiny within the agency. Agency, bureau, and program strategic plans, as well as Department of Health and Human Services (DHHS) priorities, provide the framework for planning and establishing funding priorities for evaluation studies. Studies that measure the extent to which HRSA is eliminating disparities, through measuring health outcomes and status, are typically viewed as crucial. Nonetheless, as integral as these studies are, several challenges preclude easy assessment of health outcomes. Several approaches used by the Bureau of Primary Health Care and the HIV/AIDS Bureau to address these challenges are presented. These approaches include developing uniform data sets that cross program boundaries; using existing data sources that allow inferences to be drawn about the impact that HRSA programs are having on health outcomes; conducting national surveys of populations served by HRSA programs; and conducting targeted evaluation studies at a small number of grantee locations to draw inferences from these studies about more general program impacts.
SN - 1055-6699
AD - Director of Evaluation, Bureau of Primary Health Care, Health Resources and Services Administration (HRSA), Bethesda, MD 20814
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107155517
T1 - Reducing health disparities through cultural competence.
AU - Denboba DL
AU - Bragdon JL
AU - Epstein LG
AU - Garthright K
AU - Goldman TM
Y1 - 1998/09//1998 Sep-Oct
N1 - Accession Number: 107155517. Language: English. Entry Date: 19990101. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137.
KW - Cultural Competence
KW - Health
KW - Government Regulations
KW - United States Department of Health and Human Services
SP - S47
EP - 53
JO - Journal of Health Education
JF - Journal of Health Education
JA - J HEALTH EDUC
VL - 29
IS - 5
CY - Reston, Virginia
PB - American Alliance for Health, Physical Education, Recreation & Dance
AB - Activities relating to 'cultural diversity' and 'cultural competence' have gained a greater audience with the increase in culturally diverse populations in the United States. In the area of health care, issues range from managing and preparing a more diverse workforce to eliminate disparities in health outcomes to ensuring access and utilization of services by culturally diverse communities. Cultural competence is inextricably tied to quality of care and is a cross-cutting issue affecting all service delivery systems and providers, including health educators. Health educators need to have an awareness of their own cultural values and beliefs with recognition for how they influence attitudes and behaviors (Randall-David, 1989). In addition, agencies and organizations should assess their cross-cultural strengths and weakness in terms of policies, procedures, practice, and structure. Respect for cultural values, traditions, and customs affects the willingness and ability of both individuals and organizations to develop interventions and services that affirm and reflect the value of different cultures. The extent to which interventions and services successfully affirm and reflect these values determines the appropriateness, acceptability, accessibility, and utilization of services (Epstein, 1998).
SN - 1055-6699
AD - Public Health Analyst, Division of Services for Children with Special Health Needs, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107155517&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107155519
T1 - Reducing health disparities: ideas for resource development and technical assistance.
AU - Johnston LL
AU - Denboba DL
AU - Honberg L
Y1 - 1998/09//1998 Sep-Oct
N1 - Accession Number: 107155519. Language: English. Entry Date: 19990101. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9102137.
KW - Cultural Competence
KW - Health Education
KW - Government Agencies
KW - Information Resources
KW - Pamphlets
KW - Violence -- Prevention and Control
KW - Child Safety
KW - Medically Underserved
SP - S54
EP - 8
JO - Journal of Health Education
JF - Journal of Health Education
JA - J HEALTH EDUC
VL - 29
IS - 5
CY - Reston, Virginia
PB - American Alliance for Health, Physical Education, Recreation & Dance
AB - Health professionals concerned about promoting health education activities, concepts, positive behaviors, and community involvement are constantly looking for new and better ways to demonstrate the success of their programs; communicate their messages; and reinforce the mission of public health, which is defined as fufilling society's interest in assuring conditions in which people can be healthy (Institute of Medicine, 1988). This ongoing search for new resources for education, training, and/or technical assistance is an integral component of building capacity at the community level and strengthening the ability of health professionals to provide health information. Health information in this article is being defined as the content of communications based on data derived from systemic and scientific methods as they relate to health issues, policies, program, service, and other aspects of individual and public health, which can be used for informing various populations and in planning health education activities (Report of the 1990 Joint Committee on Health Education Terminology). An excellent example of building such capacity for health professionals is through the Journal of Health Education's Community Learning Ideas and Procedures (CLIPS) Column, which promotes ideas and procedures related to models that guide health educators as they work in program planning, interventions, resource development, community organization, and marketing. This article provides a CLIPS approach to resource development, technical assistance, and training as it describes the ways the Health Resources and Services Administration (HRSA) mobilizes its efforts and builds health infrastructure in order to assure comprehensive quality health care for underserved and vulnerable populations.
SN - 1055-6699
AD - Health Education Manager, Office of Communications, Office of the Administrator, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107155519&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107183654
T1 - Causes, costs, and estimates of rabies postexposure prophylaxis treatments in the United States.
AU - Krebs JW
AU - Long-Marin SC
AU - Childs JE
Y1 - 1998/09//1998 Sep
N1 - Accession Number: 107183654. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Rabies
KW - Postexposure Follow-Up -- Economics
KW - Rabies -- Epidemiology
KW - United States
KW - Animals
SP - 56
EP - 62
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 4
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - Public Health Scientist, Epidemiology Section, Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (United States Public Health Service), Atlanta, GA
U2 - PMID: 10187067.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107183654&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107287947
T1 - Device errors. Pulse oximeters.
AU - Gallauresi BA
Y1 - 1998/09//
N1 - Accession Number: 107287947. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Pulse Oximetry -- Nursing
KW - Taping and Strapping -- Adverse Effects
KW - Peripheral Circulation
KW - Tissue Perfusion
KW - Finger Injuries
KW - Nursing Assessment
KW - Aged
KW - Female
KW - Inpatients
SP - 31
EP - 31
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9775878.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107287947&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Cellular Phone Interference Testing of Implantable Cardiac Defibrillators In Vitro.
AU - Bassen, Howard I.
AU - Moore, Hans J.
AU - Ruggera, Paul S.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1998/09//
VL - 21
IS - 9
SP - 1709
EP - 1715
SN - 01478389
N1 - Accession Number: 17434053; Author: Bassen, Howard I.: 1 Author: Moore, Hans J.: 2 Author: Ruggera, Paul S.: 1 ; Author Affiliation: 1 Center for Devices and Radiological Health, Rockville, Maryland: 2 George Washington University Medical Center, Washington, DC; No. of Pages: 7; Language: English; Publication Type: Article; Update Code: 20050627
N2 - An in vitro study was undertaken to investigate the potential for cellular telephones to interfere with representative models of presently used ICDs. Digital cellular phones (DCPs) generate strong, amplitude modulated fields with pulse repetition rates near the physiological range sensed by the ICD as an arrhythmia. DCPs with Time Division Multiple Access (TDMA) pulsed amplitude modulation caused the most pronounced effect—high voltage firing or inhibition of pacing output of the ICDs. This electromagnetic interference (EMI) occurred only when the phones were within 2.3–5.8 cm of the ICD pulse generator that was submerged 0.5 cm in 0.18% saline. ICD performance always reverted to baseline when the cellular phones were removed from the immediate proximity of the ICD. Three models of ICDs were subjected to EMI susceptibility testing using two types of digital phones and one analog cellular phone, each operating at their respective maximum output power. EMI was observed in varying degrees from all DCPs. Inhibition of pacer output occurred in one ICD, and high voltage firing occurred in the two other ICDs, when a TDMA-11 Hz DCP was placed within 2.3 cm of the ICD. For the ICD that was most sensitive to delivering unintended therapy, inhibition followed by firing occurred at distances up to 5.8 cm. When a TDMA-50 Hz phone was placed at the minimum test distance of 2.3 cm, inhibition followed by firing was observed in one of the ICDs. EMI occurred most frequently when the lower portion of the monopole antenna of the cellular phone was placed over the ICD header. ABSTRACT FROM AUTHOR
KW - *IMPLANTABLE cardioverter-defibrillators
KW - *ARRHYTHMIA
KW - *HEART diseases
KW - *CARDIOGRAPHY
KW - *CARDIAC pacing
KW - CELL phones
KW - ELECTROMAGNETIC interference
KW - HIGH voltages
KW - cellular phone
KW - compatibility
KW - electromagnetic
KW - EMC
KW - interference
KW - pacemaker
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=17434053&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107187106
T1 - Cellular phone interference testing of implantable cardiac defibrillators in vitro.
AU - Bassen HI
AU - Moore HJ
AU - Ruggera PS
Y1 - 1998/09//
N1 - Accession Number: 107187106. Language: English. Entry Date: 20081219. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7803944.
KW - Wireless Communications
KW - Defibrillators, Implantable
KW - Equipment Failure
KW - Electromagnetic Fields -- Adverse Effects
KW - Electrocardiography
KW - In Vitro Studies
KW - Human
SP - 1709
EP - 1715
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
JA - PACING CLIN ELECTROPHYSIOL
VL - 21
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - An in vitro study was undertaken to investigate the potential for cellular telephones to interfere with representative models of presently used ICDs. Digital cellular phones (DCPs) generate strong, amplitude modulated fields with pulse repetition rates near the physiological range sensed by the ICD as an arrhythmia. DCPs with Time Division Multiple Access (TDMA) pulsed amplitude modulation caused the most pronounced effect--high voltage firing or inhibition of pacing output of the ICDs. This electromagnetic interference (EMI) occurred only when the phones were within 2.3-5.8 cm of the ICD pulse generator that was submerged 0.5 cm in 0.18% saline. ICD performance always reverted to baseline when the cellular phones were removed from the immediate proximity of the ICD. Three models of ICDs were subjected to EMI susceptibility testing using two types of digital phones and one analog cellular phone, each operating at their respective maximum output power. EMI was observed in varying degrees from all DCPs. Inhibition of pacer output occurred in one ICD, and high voltage firing occurred in the two other ICDs, when a TDMA-11 Hz DCP was placed within 2.3 cm of the ICD. For the ICD that was most sensitive to delivering unintended therapy, inhibition followed by firing occurred at distances up to 5.8 cm. When a TDMA-50 Hz phone was placed at the minimum test distance of 2.3 cm, inhibition followed by firing was observed in one of the ICDs. EMI occurred most frequently when the lower portion of the monopole antenna of the cellular phone was placed over the ICD header.
SN - 0147-8389
AD - Center for Devices and Radiological Health, Rockville, Maryland
U2 - PMID: 9744432.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107187106&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107212277
T1 - Surveillance of injuries...Mortality due to unintentional injuries in the Netherlands
AU - Halperin W
AU - Horan JM
Y1 - 1998/09//Sep/Oct98
N1 - Accession Number: 107212277. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Wounds and Injuries -- Epidemiology
KW - Disease Surveillance -- Methods
KW - Public Health
KW - Netherlands
KW - Wounds and Injuries -- Prevention and Control
KW - Data Collection Methods
SP - 424
EP - 426
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 113
IS - 5
PB - Sage Publications Inc.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226; e-mail wehl@cdc.gov
U2 - PMID: 9769767.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107212277&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 1999-10748-001
AN - 1999-10748-001
AU - Kvigne, Valborg L.
AU - Bad Heart Bull, Loretta
AU - Welty, Thomas K.
AU - Leonardson, Gary R.
AU - Lacina, Loralei
T1 - Relationship of prenatal alcohol use with maternal and prenatal factors in American Indian women.
JF - Biodemography and Social Biology
JO - Biodemography and Social Biology
JA - Biodemography Soc Biol
Y1 - 1998///Fal-Win 1998
VL - 45
IS - 3-4
SP - 214
EP - 222
CY - US
PB - Society for the Study of Social Biology
SN - 1948-5565
SN - 1948-5573
N1 - Accession Number: 1999-10748-001. Other Journal Title: Eugenics Quarterly. Partial author list: First Author & Affiliation: Kvigne, Valborg L.; Aberdeen Area Indian Health Service, Public Health Service Indian Hosp, Rapid City, SD, US. Release Date: 19990501. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; American Indians; Pregnancy; Prenatal Exposure; Psychosocial Factors. Minor Descriptor: At Risk Populations; Demographic Characteristics. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 9. Issue Publication Date: Fal-Win 1998.
AB - Examined the maternal, demographic and prenatal factors associated with alcohol use as part of a study to validate a self-administered substance use screening questionnaire (SAQ) for assessment of prenatal alcohol use in Northern Plains Indian women. Ss were 177 American Indian women who completed the SAQ while waiting to see their primary health provider. Within this group, 44% of Ss did not drink during pregnancy while 56% did consume alcohol during this period. Results indicate that Ss who drank during pregnancy were more likely to be single, have less education and were less likely to have access to transportation than women who did not drink. Also, these Ss' consumed more alcohol more frequently before pregnancy than did women who drank before but not during pregnancy. Compared to women who did not drink during pregnancy, women who drank during pregnancy were more likely to smoke cigarettes and use illicit drugs, to have parents who drank, to feel they drank the same or more than other pregnant women, or to have experience more relationship breakups and physical and emotional abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal & prenatal demographic & other factors in prenatal alcohol usage
KW - American Indian females who drank before &/vs during pregnancy
KW - 1998
KW - Alcohol Drinking Patterns
KW - American Indians
KW - Pregnancy
KW - Prenatal Exposure
KW - Psychosocial Factors
KW - At Risk Populations
KW - Demographic Characteristics
KW - 1998
DO - 10.1080/19485565.1998.9988974
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1999-10748-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Vanyushin, Boris F.
AU - Lopatina, Nadezhda G.
AU - Wise, Carolyn K.
AU - Fullerton, Floyd R.
AU - Poirier, Lionel A.
T1 - Butylated hydroxytoluene modulates DNA methylation in rats.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1998/09/15/Sep98 Part 2
VL - 256
IS - 3
M3 - Article
SP - 518
EP - 527
SN - 00142956
AB - The major observation of this investigation is that a single intraperitoneal injection of butylated hydroxytoluene (BHT, 60 mg/kg body mass) results within a few hours in a strong increase in nuclear DNA(cytosine-5)-methyl transferase (methyl transferase) activity in the liver, kidneys, heart, spleen, brain and lungs of male rats. In most organs, the rise in methyl transferase activity is observed as early as 4 h after BHT injection, it reaches a maximum at 8 h and then, except for lungs and brain, gradually decreases to its initial level at 16 h. At the maximum induction times, the methyl transferase activity in liver, kidney and spleen increases by about 16-, 3- and 5-fold, respectively. A second BHT injection at 96 h results in a secondary rise in hepatic methyl transferase activity. Isoelectric focusing electrophoresis of control rat liver nuclear extracts showed methyl transferase activity in the pI 4.7 and 7.4 protein fractions. Both fractions methylate calf thymus DNA better than they do Drosophila melanogaster DNA. In similar extracts from BHT-treated rats, the methyl transferase activity is found in three protein fractions with pI values equal to 4.0, 6.2 and 9.5, respectively. Most of the methyl transferase fractions from the livers of BHT-treated rats methylate the completely unmethylated D. melanogaster DNA better than they do calf thymus DNA. Thus, BHT induces methyl transferase activity that preferably provides de novo DNA methylation. BHT injection had no significant effect on the hepatic contents of S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy) and AdoMet/AdoHcy ratios. While BHT injection did not alter the 5-methyldeoxycytidine content in liver DNA, it did appear to alter such content in other organs. BHT appears to cause the reversible changes in the methylation status of an internal cytosine residue in some CCGG sites of the rat liver cytosine DNA-methyl transferase gene. BHT induces also hypomethylation of the renal methyl... [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - CELL differentiation
KW - MESSENGER RNA
KW - METHYLATION
KW - 5-methyldeoxycytidine.
KW - Butylated hydroxytoluene
KW - cancer
KW - DNA methyl transferase
KW - DNA methylation
N1 - Accession Number: 5276956; Vanyushin, Boris F. 1; Lopatina, Nadezhda G. 2; Wise, Carolyn K. 2; Fullerton, Floyd R. 2; Poirier, Lionel A. 2; Source Information: Sep98 Part 2, Vol. 256 Issue 3, p518; Subject: DNA; Subject: CELL differentiation; Subject: MESSENGER RNA; Subject: METHYLATION; Author-Supplied Keyword: 5-methyldeoxycytidine.; Author-Supplied Keyword: Butylated hydroxytoluene; Author-Supplied Keyword: cancer; Author-Supplied Keyword: DNA methyl transferase; Author-Supplied Keyword: DNA methylation; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 2 Charts, 10 Graphs; Document Type: Article
L3 - 10.1046/j.1432-1327.1998.2560518.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107290205
T1 - Brief report. Contamination of botanical dietary supplements by Digitalis lanata.
AU - Slifman NR
AU - Obermeyer WR
AU - Aloi BK
AU - Musser SM
AU - Correll WA Jr.
AU - Cichowicz SM
AU - Betz JM
AU - Love LA
Y1 - 1998/09/17/
N1 - Accession Number: 107290205. Language: English. Entry Date: 19981001. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Dietary Supplementation -- Adverse Effects
KW - Digitalis Glycosides -- Poisoning
KW - Plants, Toxic
KW - Plant Poisoning
KW - Consumer Product Safety
KW - Chromatography
KW - Plants, Medicinal -- Administration and Dosage
KW - Digitalis Glycosides -- Pharmacodynamics
KW - Female
KW - Adult
KW - Middle Age
KW - Food Contamination
KW - United States Food and Drug Administration
SP - 806
EP - 811
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 339
IS - 12
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Clinical Research and Review Staff, Office of Special Nutritionals, Division of Natural Products, Office of Plant and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC
U2 - PMID: 9738088.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107290205&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107303755
T1 - Targeting the underserved for breast and cervical cancer screening: the utility of ecological analysis using the National Health Interview Survey.
AU - Wells BL
AU - Horm JW
Y1 - 1998/10//
N1 - Accession Number: 107303755. Language: English. Entry Date: 19981201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Health Resource Utilization
KW - Medically Underserved
KW - Research Methodology -- Evaluation
KW - Cancer Screening
KW - Ecological Research
KW - Survey Research
KW - Independent Variable
KW - Cervical Smears
KW - Data Analysis Software
KW - Logistic Regression
KW - Linear Regression
KW - Odds Ratio
KW - Confidence Intervals
KW - Breast Neoplasms -- Prevention and Control
KW - Cervix Neoplasms -- Prevention and Control
KW - Sampling Methods
KW - Mammography
KW - Poverty
KW - Educational Status
KW - Hispanics
KW - Women's Health
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Human
SP - 1484
EP - 1489
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 10
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study tested the utility of ecological variables created from the National Health Interview Survey (NHIS) for strategic targeting of health services for the underserved. METHODS: Ecological variables were created using the 1989-1991 survey years of the NHIS public use data files. Segments, the NHIS secondary sampling units, permit computation of secondary sampling characteristics by percentage Black, percentage Hispanic, percentage below poverty, percentage unemployed, median education, median income, median age, and percentage residing in the United States for 5 years or less. These variables were analyzed with the NHIS Health Promotion and Disease Prevention 1990 supplement reporting mammogram, clinical breast examination, and Pap test use. RESULTS: Median education of areas was inversely related to never having mammograms. Areas with a high proportion (70%-100%) of Hispanic respondents also were more likely not to have mammograms. Women residing in areas with moderate or high proportions of Hispanic respondents were more likely never to have clinical breast examinations and Pap tests, as were those in areas with low income, poverty, and respondents who had resided in the United States 5 years or less. CONCLUSIONS: The new methodology of constructing ecological variables using the NHIS demonstrates an application that may help identify underserved areas or areas with underutilized services. More studies using this methodology are warranted.
SN - 0090-0036
AD - Office of Data, Evaluation, Analysis, and Research, Bureau of Primary Health Care, Health Resources and Services Administration, 4350 East West Highway, Room 7-3A2, Bethesda, MD 20814
U2 - PMID: 9772849.
DO - 10.2105/AJPH.88.10.1484
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stevenson, Mark R.
AU - Wallace, L. J. David
AU - Harrison, James
AU - Jerry Moller
AU - Smith, Richard J.
T1 - At risk in two worlds: Injury mortality among Indigenous people in the US and Australia, 1990-92.
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 1998/10//
VL - 22
IS - 6
M3 - Article
SP - 641
SN - 13260200
AB - This paper outlines the commonalties and unique differences in injury experience among the Indigenous people in the United States and Australia. Injury mortality rates among Indigenous people in the United States and Australia are approximately 2–3 times greater than rates for the non-Indigenous population in each country. Motor vehicle-related injuries accounted for one-third of the injury deaths for Native Americans and Australian Aboriginals. Suicide accounted for more deaths in Native Americans (15.5 per 100,000) than it did for Australian Aboriginals (11.1 per 100,000), whereas the injury death rate in Australian Aboriginals due to poisoning was almost twice that of Native Americans. Culturally appropriate interventions tailored to specific local settings and problems will be necessary to reduce injury mortality among Indigenous people. [ABSTRACT FROM AUTHOR]
AB - Copyright of Australian & New Zealand Journal of Public Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDIGENOUS peoples
KW - WOUNDS & injuries
KW - MORTALITY
KW - TRAFFIC accidents
KW - SUICIDE
KW - POISONING
KW - DEATH -- Causes
KW - ETHNIC groups
KW - UNITED States
KW - AUSTRALIA
N1 - Accession Number: 1484632; Stevenson, Mark R. 1,2; Wallace, L. J. David 2; Harrison, James 3; Jerry Moller 3; Smith, Richard J. 4; Affiliations: 1: Department of Epidemiology and Biostatistics, School of Public Health, Curtin University of Technology, Western Australia; 2: National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, United States; 3: AIHW — National Injury Surveillance Unit, Flinders University of South Australia; 4: Indian Health Service, United States; Issue Info: Oct98, Vol. 22 Issue 6, p641; Subject Term: INDIGENOUS peoples; Subject Term: WOUNDS & injuries; Subject Term: MORTALITY; Subject Term: TRAFFIC accidents; Subject Term: SUICIDE; Subject Term: POISONING; Subject Term: DEATH -- Causes; Subject Term: ETHNIC groups; Subject: UNITED States; Subject: AUSTRALIA; Number of Pages: 4p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107299700
T1 - From the Food and Drug Administration. Reports of anesthesia-related adverse events.
AU - Graham A
Y1 - 1998/10//1998 Oct-Dec
N1 - Accession Number: 107299700. Language: English. Entry Date: 19981201. Revision Date: 20150820. Publication Type: Journal Article; case study. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Equipment Failure
KW - Anesthesia Equipment and Supplies
KW - Voluntary Reporting
KW - United States Food and Drug Administration
SP - 139
EP - 145
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 4
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - US FDA, Center for Devices and Radiological Health, Rockville, MD
U2 - PMID: 9855986.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107294224
T1 - Device errors. Sharps containers.
AU - Morrison A
Y1 - 1998/10//
N1 - Accession Number: 107294224. Language: English. Entry Date: 19981101. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Sharps Disposal
KW - Needlestick Injuries -- Prevention and Control
SP - 73
EP - 73
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Take these steps to avoid getting stuck.
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 9801595.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ramaiah, Shashi K.
AU - Bucci, Thomas J.
AU - Warbritton, Alan
AU - Soni, Madhusudan G.
AU - Mehendale, Harihara M.
T1 - Temporal Changes in Tissue Repair Permit Survival of Diet-Restricted Rats from an Acute Lethal Dose of Thioacetamide.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1998/10//
VL - 45
IS - 2
M3 - Article
SP - 233
EP - 241
SN - 10966080
AB - Although, diet restriction (DR) has been shown to substantially increase longevity while reducing or delaying the onset of agerelated diseases, little is known about the mechanisms underlying the beneficial effects of DR on acute toxic outcomes. An earlier study (S. K. Ramaiah et al., 1998, Toxicol. Appl. Pharmacol. 150, 12–21) revealed that a 35% DR compared to ad libitum (AL) feeding leads to a substantial increase in liver injury of thioacetamide (TA) at a low dose (50 mg/kg, ip). Higher liver injury was accompanied by enhanced survival. A prompt and enhanced tissue repair response in DR rats at the low dose (sixfold higher liver injury) occurred, whereas at equitoxic doses (50 mg/kg in DR and 600 mg/kg in AL rats) tissue repair in AL rats was substantially diminished and delayed. The extent of liver injury did not appear to be closely related to the extent of stimulated tissue repair response. The purpose of the present study was to investigate the time course (0–120 h) of liver injury and liver tissue repair at the high dose (600 mg TA/kg, ip, lethal in AL rats) in AL and DR rats. Male Sprague-Dawley rats (225–275 g) were 35% diet restricted compared to their AL cohorts for 21 days and on day 22 they received a single dose of TA (600 mg/kg, ip). Liver injury was assessed by plasma ALT and by histopathological examination of liver sections. Tissue repair was assessed by [3H]thymidine incorporation into hepatonuclear DNA and proliferating cell nuclear antigen (PCNA) immunohistochemistry during 0–120 h after TA injection. In AL-fed rats hepatic necrosis was evident at 12 h, peaked at 60 h, and persisted thereafter until mortality (3 to 6 days). Peak liver injury was approximately twofold higher in DR rats compared to that seen in AL rats. Hepatic necrosis was evident at 36 h, peaked at 48 h, persisted until 96 h, and returned to normal by 120 h. Light microscopy of liver sections revealed progression of hepatic injury in AL rats whereas injury regressed completely leading to recovery of DR rats by 120 h. Progression of injury led to 90% mortality in AL rats vs 30% mortality in DR group. In the surviving AL rats, S-phase DNA synthesis was evident at 60 h, peaked at 72 h, and declined to base level by 120 h, whereas in DR rats S-phase DNA synthesis was evident at 36 h and was consistently higher until 96 h reaching control levels by 120 h. PCNA studies showed a corresponding increase in cells in S and M phase in the AL and DR groups. DR resulted in abolition of the delay in tissue repair associated with the lethal dose of TA in ad libitum rats. Temporal changes and higher tissue repair response in DR rats (earlier and prolonged) are the conduits that allow a significant number of diet restricted rats to escape lethal consequence. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 83181343; Ramaiah, Shashi K. 1,2; Bucci, Thomas J. 2; Warbritton, Alan 2; Soni, Madhusudan G. 1,2; Mehendale, Harihara M. 1,2; Affiliations: 1: Division of Toxicology and Louisiana Institute of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University Monroe, Louisiana 71209-0470; 2: Pathology Associates, Inc., National Center for Toxicological Research Jefferson, Arkansas 72079; Issue Info: 1998, Vol. 45 Issue 2, p233; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107156911
T1 - US Food and Drug Administration: adverse event reporting.
AU - Graham AA
Y1 - 1998/11//1998 Nov
N1 - Accession Number: 107156911. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9109511.
KW - Mandatory Reporting
KW - Anesthesia Equipment and Supplies
KW - United States Food and Drug Administration
KW - Equipment Failure
KW - Ventilators, Mechanical
KW - Laryngeal Masks
KW - Anesthesia Equipment and Supplies -- Adverse Effects
SP - 135
EP - 138
JO - CRNA: the Clinical Forum for Nurse Anesthetists
JF - CRNA: the Clinical Forum for Nurse Anesthetists
JA - CRNA
VL - 9
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - This article reviews adverse event reports associated with anesthesia devices submitted to the US Food and Drug Administration during the period of August 15, 1896 to August 15, 1998. Cardiovascular, general surgical, and plastic surgical devices are the most frequently reported devices. Deaths are most frequently associated with cardiovascular, general hospital, and gastrourological devices. The most frequently reported failures associated with ventilators are failures of audio or visual alarm systems. This is a US government work. There are no restrictions on its use.
SN - 1048-2687
AD - US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD
U2 - PMID: 9866488.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107158723
T1 - Myositis and myopathies.
AU - Miller FA
Y1 - 1998/11//1998 Nov
N1 - Accession Number: 107158723. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9000851.
KW - Muscular Diseases
SP - 499
EP - 561
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
JA - CURR OPIN RHEUMATOL
VL - 10
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1040-8711
AD - Center for Biologics Evaluation and Research, FDA, Laboratory of Molecular and Developmental Immunology, Building 29B, Room 2G11, HFM-521, Bethesda, MD, 20892
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miller, A. J.
AU - Eblen, B. S.
AU - Oser, A.
AU - Burkhardt, W.
T1 - Application and evaluation of male-specific bacteriophage as a process integrity or faecal contamination indicator in a pork slaughterhouse environment.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 1998/11//
VL - 85
IS - 5
M3 - Article
SP - 898
EP - 904
PB - Wiley-Blackwell
SN - 13645072
AB - A male-specific bacteriophage plaque assay was evaluated as a faecal contamination or process integrity indicator for aspects of the pork slaughter process. Over 400 samples were tested including: sponge swabs from animal hauling trailer floors and dressed carcass surfaces; faecal material; water from slaughter sites; and water from each stage of wastewater treatment. Bacteriophage were observed in wastewater, trailers, slaughter process water and swine faeces. No bacteriophage were observed on dressed carcasses. Numbers of phage plaque-forming units per gram or millilitre showed greater variation and were usually lower than standard indicators, including total coliform or Escherichia coli counts. Among the applications studied, male-specific bacteriophage appear to be best suited for process control verification for wastewater treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteriophages
KW - Microbial contamination
KW - Slaughtering & slaughterhouses
N1 - Accession Number: 5277778; Miller, A. J. 1; Eblen, B. S. 1; Oser, A. 2; Burkhardt, W. 3; Affiliations: 1: Microbial Food Safety Research Unit, Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA,; 2: Hatfield Meats, Inc., Hatfield, PA, and; 3: U.S. Public Health Service, U.S. Food & Drug Administration, AL, USA; Issue Info: Nov98, Vol. 85 Issue 5, p898; Thesaurus Term: Bacteriophages; Thesaurus Term: Microbial contamination; Thesaurus Term: Slaughtering & slaughterhouses; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Margaret E. K. Kraeling
AU - Gunda Reddy
AU - Robert L. Bronaugh
T1 - Percutaneous absorption of trinitrobenzene: animal models for human skin.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 1998/11//Nov/Dec1998
VL - 18
IS - 6
M3 - Article
SP - 387
EP - 392
SN - 0260437X
AB - The percutaneous absorption of 1,3,5-trinitrobenzene (TNB) was studied in viable skin from hairless guinea pigs (HGP), Fischer 344 rats and humans. Skin was dermatomed and assembled in flow-through diffusion cells followed by TNB application in either an acetone or a water vehicle. Skin absorption was expressed as the percentage of applied dose absorbed into skin and receptor fluid within 24 h. Rapid absorption of TNB by rodent skin was obtained with both vehicles. For HGP skin, TNB absorption was 72.7 ± 5.5% in the acetone vehicle and 82.3 ± 4.5% in the water vehicle. For rat skin, TNB absorption was 61.0 ± 4.1% (acetone) and 66.5 ± 4.1% (water). Absorption of TNB from acetone was significantly reduced (38.0 ± 11.0%, P = 0.0118) in human skin, but absorption from water remained high (75.5 ± 10.8%). Little TNB remained in skin when a thin (200 μm) dermatome section was used (HGP and human skin). A thicker dermatome section was required (350 μm) with haired rat skin, and 13–21% of the absorbed radioactivity remained in the skin at 24 h. Rodent skin did not simulate satisfactorily the barrier properties of human skin when TNB absorption was reduced by application in a volatile solvent. Copyright © 1998 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Caviidae
KW - Benzene
KW - Skin absorption
KW - Packed towers (Chemical engineering)
N1 - Accession Number: 18468068; Margaret E. K. Kraeling 1; Gunda Reddy 2; Robert L. Bronaugh 1; Affiliations: 1: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA; 2: of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA, A1 , US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD 21010, USA; Issue Info: Nov/Dec1998, Vol. 18 Issue 6, p387; Thesaurus Term: Caviidae; Thesaurus Term: Benzene; Subject Term: Skin absorption; Subject Term: Packed towers (Chemical engineering); NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107221797
T1 - Final-year-of-life pacemaker recipients.
AU - Hefflin BJ
Y1 - 1998/11//11/ 1/1998
N1 - Accession Number: 107221797. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062.
KW - Activities of Daily Living
KW - Pacemaker, Artificial -- Adverse Effects
KW - Pacemaker, Artificial -- Psychosocial Factors
KW - Patient Selection
KW - Chi Square Test
KW - Analysis of Variance
KW - Mortality
KW - Cross Sectional Studies
KW - Geriatric Assessment
KW - Disease Surveillance
KW - Quality of Life
KW - Retrospective Design
KW - Risk Factors
KW - Survival Analysis
KW - United States
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 1396
EP - 1400
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND: Older persons who have initial cardiac pacemakers implanted during their final year of life have not been characterized as a group, which makes it difficult to evaluate the suitability of some of their health services utilizations. OBJECTIVE: To help determine how prudently pacemakers are used in this group, we assessed its pacemaker candidates from the perspective of health and ability to perform physical activities of daily living. DESIGN: A retrospective, population-based, cross-sectional study. SETTING: The 1993 National Mortality Followback Survey. PARTICIPANTS: An estimated 1,647,955 persons aged 65 years or older who died in the US in 1993. MEASUREMENTS: Demographic and cause-of-death frequencies obtained by analyzing age, sex, race, and underlying cause-of-death variables in the survey. For persons who had initial pacemakers implanted during their last year of life, we determined the percent of persons, within 10-year age groups, who had no difficulty at any time during their final year of life performing 11 specific physical activities of daily living (e.g., climbing stairs, preparing meals, bathing). These data were obtained from negative responses to questions that asked if the decedents, at any time during their last year of life, had difficulty performing the specific activities. RESULTS: Of the estimated 78,941 persons aged 65 years or older with a pacemaker who died in the US in 1993, 14,158 (18%) had their first pacemaker implanted during their last year of life. Estimated median survival of the final-year-of-life recipients of pacemakers after pacemaker implantation was 5 months. Compared with the general older population that died in 1993, the final-year-of-life recipients of pacemakers group had higher percentages of persons who died of acute disorders (49% vs 19%) and who lived alone in a private home (47% vs 20%), and a lower percentage of persons with Alzheimer's disease (1% vs 7%). The age-stratified means of the percentages of final-year-of-life recipients of pacemakers who had no difficulty performing each physical activity of daily living were all greater than 50. CONCLUSION: Our results suggest that older persons who had initial pacemakers implanted during their final year of life and who died in 1993 were not terminally ill, inactive pacemaker candidates, in general, but relatively independent, physically functional candidates who frequently died abruptly. The physical, mental, and life expectancy factors recommended for consideration by expert guidelines for the implantation of cardiac pacemakers were generally applied to persons in this subgroup.
SN - 0002-8614
AD - Food and Drug Administration, HFZ-541, 1350 Piccard Dr., Rockville, MD 20850
U2 - PMID: 9809761.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Parsons, Barbara L.
AU - Heflich, Robert H.
T1 - Detection of a mouse H-ras codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 1998/11//
VL - 13
IS - 6
M3 - Article
SP - 581
EP - 588
PB - Oxford University Press / USA
SN - 02678357
AB - A modified allele-specific competitive blocker PCR (ACB-PCR) has been developed as an approach for genotypic selection, the detection of a rare mutant allele based solely upon its altered nucleotide sequence. ACB-PCR genotypic selection operates through the preferential PCR amplification of mutant DNA using a primer that has more mismatches to the wild-type allele than the mutant allele. In addition, a blocker-primer with a 3′-terminal dideoxynucleotide and more mismatches to the mutant allele than the wild-type allele is incorporated to reduce the background and increase sensitivity. Using ACB-PCR, the CAA→AAA base substitution at codon 61 of the mouse H-ras gene was detected regularly at mutant fractions of 10−5. To accurately quantify the occurrence of this particular mutation, an internal amplification standard (AS) DNA was constructed. The H-ras and AS DNAs were subject to the same genotypic selection but were amplified using different upstream primers to give PCR products that can be distinguished by size. Defined mixtures of mutant and wild-type AS DNAs were used to study the effects of various components of the ACB-PCR. The concentration of dNTPs, blocker primer and Perfect Match® Polymerase Enhancer, as well as the choice of thermostable DNA polymerase and annealing temperature were examined. Conditions were identified for the concurrent detection of the CAA→AAA mutation in the H-ras and AS DNAs. Using the identified conditions, approximately equal signals were obtained from equivalent amounts of the two DNA templates over a wide range of mutant fractions (1 in 10 to 1 in 105). This ACB-PCR method can be used for any application where it is necessary to quantify relatively small mutant fractions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Genetic code
KW - Mice as laboratory animals
KW - Ras oncogenes
KW - Alleles
KW - Polymerase chain reaction
KW - Nucleotide sequence
N1 - Accession Number: 79238010; Parsons, Barbara L.; Heflich, Robert H. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, HFT-120, National Center for Toxicological Research 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Nov1998, Vol. 13 Issue 6, p581; Thesaurus Term: Mutation (Biology); Subject Term: Genetic code; Subject Term: Mice as laboratory animals; Subject Term: Ras oncogenes; Subject Term: Alleles; Subject Term: Polymerase chain reaction; Subject Term: Nucleotide sequence; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107157170
T1 - The intrauterine device: dispelling the myths.
AU - Kimble-Haas SL
Y1 - 1998/11//1998 Nov
N1 - Accession Number: 107157170. Language: English. Entry Date: 19990101. Revision Date: 20150819. Publication Type: Journal Article; consumer/patient teaching materials; pictorial; protocol; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7603663.
KW - Intrauterine Devices
KW - Gynecologic Care
KW - Intrauterine Devices -- History
KW - Intrauterine Devices -- Contraindications
KW - Intrauterine Devices -- Adverse Effects
KW - Patient Education
KW - Patient Selection
KW - Female
SP - 58
EP - 69
JO - Nurse Practitioner
JF - Nurse Practitioner
JA - NURSE PRACT
VL - 23
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The worldwide popularity and usage of intrauterine devices (IUDs) plummeted in the 1970s, when grim reports of septic abortions and pelvic inflammatory disease were published. Although the Dalkon Shield ultimately was determined to be the culprit for these problems, the reputation of all IUDs was damaged, and their popularity spiraled downward. The stigma continues, despite the proven safety and efficacy of newer IUDs, particularly the ParaGard T 380A and the Progestasert, which are now the only two IUDs approved for use in the United States. This article will review how the IUD works and will focus on dispelling the misconceptions surrounding its use. Rigid patient-selection guidelines and strict aseptic insertion techniques can provide safe, long-term, cost-effective, and highly efficacious contraception for monogamous women. Practitioners who follow these guidelines should not fear prescribing IUDs as a contraceptive device in the appropriate female population.
SN - 0361-1817
AD - Family Nurse Practitioner, Public Health Service Indian Hospital, Outpatient Clinic, Pine Ridge, SD
U2 - PMID: 9834505.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107156993
T1 - Device errors. Percutaneous sheath introducer...precautions to avoid air embolisms
AU - Liu CK
Y1 - 1998/11//
N1 - Accession Number: 107156993. Language: English. Entry Date: 19990101. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Vascular Access Devices -- Nursing
KW - Catheterization, Central Venous -- Adverse Effects
KW - Embolism, Air -- Prevention and Control
KW - Pulmonary Artery Catheters
KW - Equipment Design
KW - Adult
KW - Male
KW - Inpatients
SP - 84
EP - 84
JO - Nursing
JF - Nursing
JA - NURSING
VL - 28
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Take these precautions to avoid air embolism.
SN - 0360-4039
AD - Center for Devices and Radiological Health Food and Drug Adm Administration, Rockville, Md
U2 - PMID: 9856046.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107102587
T1 - Silicone gel breast implant adverse event reports to the Food and Drug Administration, 1984-1995.
AU - Brown SL
AU - Parmentier CM
AU - Woo EK
AU - Vishnuvajjala RL
AU - Headrick ML
Y1 - 1998/11//Nov/Dec98
N1 - Accession Number: 107102587. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Breast Implants -- Adverse Effects
KW - Silicones -- Adverse Effects
KW - Mandatory Reporting -- Evaluation
KW - Voluntary Reporting -- Evaluation
KW - Evaluation Research
KW - Comparative Studies
KW - Record Review
KW - Data Analysis Software
KW - Death Certificates
KW - Mortality
KW - United States Food and Drug Administration
KW - Foreign-Body Reaction -- Symptoms
KW - Registries, Disease
KW - Foreign-Body Reaction -- Classification
KW - Breast Neoplasms -- Mortality
KW - Autoimmune Diseases -- Mortality
KW - Female
KW - Human
SP - 535
EP - 543
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 113
IS - 6
PB - Sage Publications Inc.
AB - OBJECTIVES: To characterize the adverse event reports on silicone gel breast implants (SGBIs), including death reports, submitted to the Food and Drug Administration (FDA) from 1984 through 1995 and to analyze changes in the type and complexity of reports following extensive media coverage of breast implants. METHODS: The authors analyzed mandatory and voluntary reports from the adverse events reporting system for medical devices at the FDA. RESULTS: In 1988, adverse event reports related to SGBIs accounted for 2.4% of the 14,473 mandatory reports entered into the FDA database on medical devices. In 1992, SGBI-related reports accounted for 30.3% of the total 66,476 mandatory reports of adverse events. The most frequently reported adverse event in 1988, before the widespread publicity on breast implants, was implant burst or rupture. In contrast, in 1992 the most frequently reported event was reaction, a term used to describe a range of adverse effects. CONCLUSIONS: The numbers of mandatory and voluntary reports of SGBI-related adverse events increased exponentially, as did the complexity of the reports, following publicity over the lack of safety data on breast implants and a short voluntary moratorium on their sale. A significant proportion of reports lacked information on specific medical symptoms or diagnoses.
SN - 0033-3549
AD - Senior Research Scientist, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, HFZ-541, Rockville, MD 20850. E-mail: syb@cdrh.fda.gov
U2 - PMID: 9847926.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2012-10351-002
AN - 2012-10351-002
AU - Rosenheck, Robert
AU - Morrissey, Joseph
AU - Lam, Julie
AU - Calloway, Michael
AU - Johnsen, Matthew
AU - Goldman, Howard
AU - Randolph, Frances
AU - Blasinsky, Margaret
AU - Fontana, Alan
AU - Calsyn, Robert
AU - Teague, Gregory
T1 - Service system integration, access to services, and housing outcomes in a program for homeless persons with severe mental illness.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 1998/11//
VL - 88
IS - 11
SP - 1610
EP - 1615
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Rosenheck, Robert, VA Medical Center, West Haven, CT, US, 06516
N1 - Accession Number: 2012-10351-002. PMID: 9807525 Partial author list: First Author & Affiliation: Rosenheck, Robert; Department of Veterans Affairs, Northeast Program Evaluation Center, West Haven, CT, US. Release Date: 20130325. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Homeless Mentally Ill; Mental Disorders. Minor Descriptor: Community Services; Housing. Classification: Psychological Disorders (3210); Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Empirical Study; Followup Study; Interview; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 1998. Publication History: Accepted Date: Mar 11, 1998.
AB - Objectives: This study evaluated the hypothesis that greater integration and coordination between agencies within service systems is associated with greater accessibility of services and improved client housing outcomes. Methods: As part of the Access to Community Care and Effective Services and Supports program, data were obtained on baseline client characteristics, service use, and 3-month and 12-month outcomes from 1832 clients seen at 18 sites during the first year of program operation. Data on interorganizational relationships were obtained from structured interviews with key informants from relevant organizations in each community (n = 32-82 at each site). Results: Complete follow-up data were obtained from 1340 clients (73%). After control for baseline characteristics, service system integration was associated with superior housing outcomes at 12 months, and this relationship was mediated through greater access to housing agencies. Conclusions: Service system integration is related to improved access to housing services and better housing outcomes among homeless people with mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service system integration
KW - housing outcomes
KW - homeless persons
KW - severe mental illness
KW - 1998
KW - Homeless Mentally Ill
KW - Mental Disorders
KW - Community Services
KW - Housing
KW - 1998
U1 - Sponsor: US Department of Health and Human Services, Public Health Service, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: Interagency Agreement AM9512200A. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, Northeast Program Evaluation Center, US. Recipients: No recipient indicated
U1 - Sponsor: Center for Mental Health Services/ROW Sciences Inc.. Recipients: No recipient indicated
U1 - Sponsor: ROW Sciences Inc./Cecil G. Sheps Center for Health Services Research at University of North Carolina at Chapel Hill. Recipients: No recipient indicated
DO - 10.2105/AJPH.88.11.1610
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2012-10351-002&site=ehost-live&scope=site
UR - robert.rosenheck@yale.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107186767
T1 - Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers.
AU - Calvert GM
AU - Mueller CA
AU - Fajen JM
AU - Chrislip DW
AU - Russo J
AU - Briggle T
AU - Fleming LE
AU - Suruda AJ
AU - Steenland K
Y1 - 1998/12//
N1 - Accession Number: 107186767. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: University of Pennsylvania Smell Identification Test (UPSIT); Neurobehavioral Evaluation System (NES); Santa Ana Dexterity Test. NLM UID: 1254074.
KW - Occupational Diseases
KW - Occupational Exposure
KW - Pesticides -- Adverse Effects
KW - Nervous System Diseases -- Chemically Induced
KW - Case Control Studies
KW - Prospective Studies
KW - Questionnaires
KW - Neuropsychological Tests
KW - T-Tests
KW - Chi Square Test
KW - Fisher's Exact Test
KW - Multiple Linear Regression
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Sulfates -- Adverse Effects
KW - Hydrocarbons, Brominated -- Adverse Effects
KW - Neurologic Examination
KW - P-Value
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Human
SP - 1774
EP - 1780
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 88
IS - 12
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study assessed the health effects associated with occupational exposure to methyl bromide and sulfuryl fluoride among structural fumigation workers. METHODS: A cross-sectional study of 123 structural fumigation workers and 120 referents in south Florida was conducted. Nerve conduction, vibration, neurobehavioral, visual, olfactory, and renal function testing was included. RESULTS: The median lifetime duration of methyl bromide and sulfuryl fluoride exposure among workers was 1.20 years and 2.85 years, respectively. Sulfuryl fluoride exposure over the year preceding examination was associated with significantly reduced performance on the Pattern Memory Test and on olfactory testing. In addition, fumigation workers had significantly reduced performance on the Santa Ana Dexterity Test of the dominant hand and a nonsignificantly higher prevalence of carpal tunnel syndrome than did the referents. CONCLUSIONS: Occupational sulfuryl fluoride exposures may be associated with subclinical effects on the central nervous system, including effects on olfactory and some cognitive functions. However, no widespread pattern of cognitive deficits was observed. The peripheral nerve effects were likely caused by ergonomic stresses experienced by the fumigation workers.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-21, Cincinnati, OH 45226. E-mail: jac6@cdc.gov
U2 - PMID: 9842373.
DO - 10.2105/AJPH.88.12.1774
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lehman, Anthony F.
AD - Center for Mental Health Services Research, U MD
T1 - The Role of Mental Health Service Research in Promoting Effective Treatment for Adults with Schizophrenia
JO - Journal of Mental Health Policy and Economics
JF - Journal of Mental Health Policy and Economics
Y1 - 1998/12//
VL - 1
IS - 4
SP - 199
EP - 204
SN - 10914358
N1 - Accession Number: 0627401; Keywords: Health; Rehabilitation; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200211
N2 - The aim of the study is to illustrate this potential, data on the efficacy of treatment for schizophrenia are reviewed. The treatments reviewed include pharmacotherapies, psychological interventions, family interventions, vocational rehabilitation and assertive community treatment and case management. Using treatment recommendations based upon outcome data about these treatments and the results of a large survey of usual care for schizophrenia from the Schizophrenia Patient Outcomes Research Team (PORT) project, examples of current deficiencies in the usual treatment of adult mental disorders and relevant questions that need to be addressed by mental health services research are identified.
KW - Analysis of Health Care Markets I11
L3 - http://www.icmpe.org/test1/journal/journal.htm
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0627401&site=ehost-live&scope=site
UR - http://www.icmpe.org/test1/journal/journal.htm
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Spisak, Shelly
AU - Holt, Katrina
AU - Mayer, Rochelle
AU - Rossetti, John
T1 - Improving Children's Access to Oral Health Services: The Oral Health Initiative.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1998/12//
VL - 2
IS - 4
M3 - Article
SP - 261
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Although major improvements have been made in oral health during the 20th century, many children in minority groups, from families with low-income, and with special health care needs still do not receive the oral health services that they need. To address the problem, the Health Resources and Services Administration (HRSA), working with the Health Care Financing Administration (HCFA), has launched the Oral Health Initiative. The initiative seeks to strengthen oral health service-delivery systems, enhance collaboration among federal agencies, and provide states with the resources needed to improve the oral health of hard-to-reach children. HRSA's activities include enhancing programs, services, and training, such as expanding the number of direct-service dental programs; establishing or enhancing graduate training programs in pediatric and general dentistry and in dental public health; and funding training programs in dentistry to train dental public health leaders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD health services
KW - ORAL medicine
KW - CHILDREN -- Health
KW - UNITED States
KW - access to care
KW - dental disease
KW - Health Resources and Services Administration
KW - managed care
KW - Medicaid, Children's Health Insurance Program (CHIP)
KW - National Maternal and Child Oral Health Resource Center
KW - oral health
KW - Oral Health Initiative
N1 - Accession Number: 11307774; Spisak, Shelly 1; Holt, Katrina 1; Mayer, Rochelle 1; Rossetti, John 2; Source Information: Dec1998, Vol. 2 Issue 4, p261; Subject: CHILD health services; Subject: ORAL medicine; Subject: CHILDREN -- Health; Geographic Terms: UNITED States; Author-Supplied Keyword: access to care; Author-Supplied Keyword: dental disease; Author-Supplied Keyword: Health Resources and Services Administration; Author-Supplied Keyword: managed care; Author-Supplied Keyword: Medicaid, Children's Health Insurance Program (CHIP); Author-Supplied Keyword: National Maternal and Child Oral Health Resource Center; Author-Supplied Keyword: oral health; Author-Supplied Keyword: Oral Health Initiative; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
AU - Hewett, Paul
T1 - Comments on Relating to Tornero-Velez et al: Compliance Versus Risk in Assessing Occupational Exposures.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1998/12//
VL - 18
IS - 6
M3 - Letter
SP - 665
EP - 667
SN - 02724332
AB - Presents a letter to the editor related to risk assessment, published in December 1998 issue of the journal "Risk Analysis."
KW - Risk assessment
KW - Letters to the editor
N1 - Accession Number: 15106372; Hewett, Paul 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Environmental Investigations Branch, 1095 Willowdale Road, Morgantown, WV 26505-2888; Issue Info: Dec98, Vol. 18 Issue 6, p665; Thesaurus Term: Risk assessment; Subject Term: Letters to the editor; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gray, George M.
AU - Allen, Jon C.
AU - Burmaster, David E.
AU - Gage, Stuart H.
AU - Hammitt, James K.
AU - Kaplan, Stanley
AU - Keeney, Ralph L.
AU - Morse, Joseph G.
AU - North, D. Warner
AU - Nyrop, Jan P.
AU - Stahevitch, Alma
AU - Wiliams, Richard
T1 - Principles for Conduct of Pest Risk Analyses: Report of an Expert Workshop.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1998/12//
VL - 18
IS - 6
M3 - Article
SP - 773
EP - 780
SN - 02724332
AB - The North American Free Trade Agreement (NAFTA) and the General Agreement on Tariffs and Trade (GATT) have focused attention on risk assessment of potential insect, weed, and animal pests and diseases of livestock. These risks have traditionally been addressed through quarantine protocols ranging from limits on the geographical areas from which a product may originate, postharvest disinfestation procedures like fumigation, and inspections at points of export and import, to outright bans. To ensure that plant and animal protection measures are not used as nontariff trade barriers, GATT and NAFTA require pest risk analysis (PRA) to support quarantine decisions. The increased emphasis on PRA has spurred multiple efforts at the national and international level to design frameworks for the conduct of these analyses. As approaches to pest risk analysis proliferate, and the importance of the analyses grows, concerns have arisen about the scientific and technical conduct of pest risk analysis. In January of 1997, the Harvard Center for Risk Analysis (HCRA) held an invitation-only workshop in Washington, D.C. to bring experts in risk analysis and pest characterization together to develop general principles for pest risk analysis. Workshop participants examined current frameworks for PRA, discussed strengths and weaknesses of the approaches, and formulated principles, based on years of experience with risk analysis in other setting and knowledge of the issues specific to analysis of pests. The principles developed highlight the both the similarities of pest risk analysis to other forms of risk analysis, and its unique attributes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agriculture
KW - Livestock
KW - Quarantine
KW - Risk assessment
KW - Pests -- Control
KW - Fumigation
KW - Diseases
KW - Disease control
KW - Expert workshop
KW - Pest control
KW - Pest risk
KW - Pest risk analysis
KW - phytosanitary
KW - Phytosanitation
KW - quarantine.
KW - Risk analysis
N1 - Accession Number: 8114977; Gray, George M. 1; Email Address: ggray@hsph.harvard.edu; Allen, Jon C. 2; Burmaster, David E. 3; Gage, Stuart H. 4; Hammitt, James K. 5; Kaplan, Stanley 6; Keeney, Ralph L. 7; Morse, Joseph G. 8; North, D. Warner 9; Nyrop, Jan P. 10; Stahevitch, Alma 11; Wiliams, Richard 12; Affiliations: 1: Harvard Center for Risk Analysis, Harvard School of Public Health, 718 Huntington Ave., Boston, Massachusens 02115; 2: Department of Entomology and Nematology, University of Florida; 3: Alceon Corp.; 4: Department of Entomology, Michigan State University; 5: Department of Health Policy and Management, Harvard School of Public Health; 6: Bayesian Systems Inc.; 7: University of Southern California; 8: Center for Exotic Pest Research and Department of Entomology, University of California at Riverside; 9: Decision Focus, Inc.; 10: Department of Entomology, Cornell University; 11: Plant Health Risk Assessment Unit, Agriculture Canada; 12: Certer for Food Safety and Applied Nutrition, Economics Branch, U.S. Food and Drug Administration; Issue Info: Dec98, Vol. 18 Issue 6, p773; Thesaurus Term: Agriculture; Thesaurus Term: Livestock; Thesaurus Term: Quarantine; Thesaurus Term: Risk assessment; Thesaurus Term: Pests -- Control; Thesaurus Term: Fumigation; Thesaurus Term: Diseases; Author-Supplied Keyword: Disease control; Author-Supplied Keyword: Expert workshop; Author-Supplied Keyword: Pest control; Author-Supplied Keyword: Pest risk; Author-Supplied Keyword: Pest risk analysis; Author-Supplied Keyword: phytosanitary; Author-Supplied Keyword: Phytosanitation; Author-Supplied Keyword: quarantine.; Author-Supplied Keyword: Risk analysis; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2015-41750-046
AN - 2015-41750-046
AU - Meredith, John M.
AU - Moffatt, Christopher A.
AU - Auger, Anthony P.
AU - Snyder, Gretchen L.
AU - Greengard, Paul
AU - Blaustein, Jeffrey D.
T1 - Mating-related stimulation induces phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in progestin receptor-containing areas in the female rat brain.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 1998/12//
VL - 18
IS - 23
SP - 10189
EP - 10195
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Blaustein, Jeffrey D., Center for Neuroendocrine Studies, University of Massachusetts, Tobin Hall, Box 37720, Amherst, MA, US, 01003
N1 - Accession Number: 2015-41750-046. PMID: 9822772 Partial author list: First Author & Affiliation: Meredith, John M.; Division of Neurotoxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR, US. Release Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Meredith, John M. Major Descriptor: Brain; Cyclic Adenosine Monophosphate; Dopamine; Neural Receptors; Phosphorylation. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 1998. Publication History: Accepted Date: Sep 16, 1998; Revised Date: Sep 10, 1998; First Submitted Date: Jul 10, 1998. Copyright Statement: Society for Neuroscience. 1998.
AB - Vaginal–cervical stimulation induces a number of physiological and behavioral events, including the facilitation of mating behavior. Although the facilitation of one component of mating behavior, lordosis, by vaginal–cervical stimulation does not require the presence of progesterone, it appears to be mediated by neural progestin receptors. Abundant evidence suggests that dopamine may play a role in the neural circuitry activated by vaginal–cervical stimulation, including the mating-induced release of dopamine in progestin receptor-containing areas of the brain, changes in the activational state of progestin receptors because of dopamine D₁ receptor stimulation, facilitation of lordosis by D₁ receptor stimulation in estradiol-primed rats via progesterone-independent events, and D₁ agonist-induced neuronal responses in progestin receptor-containing areas and cells. We tested the hypothesis that vaginal–cervical stimulation induces phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32; Mr = 32,000), a protein phosphorylated predominantly in response to the stimulation of D₁ receptors. At 9 d after ovariectomy, female rats were injected subcutaneously with a behaviorally effective dose of estradiol benzoate. At 48 hr later they received vaginal–cervical or control (perineal) stimulation, and they were perfused 1 hr later. Vaginal–cervical stimulation increased the number of cells expressing pDARPP-32 immunoreactivity by 92% in the medial preoptic nucleus, 134% in the caudal ventromedial hypothalamic nucleus, 123% in the posterodorsal medial amygdala, and 103% in the bed nucleus of the stria terminalis. These results suggest that some of the neuronal effects of vaginal– cervical stimulation, and perhaps other social or environmental stimuli, are mediated by phosphorylation of DARPP-32, perhaps via stimulation of D₁ receptors, within progestin receptor-containing areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vaginal–cervical stimulation
KW - cervical stimulation
KW - dopamine
KW - estradiol
KW - progestin receptors
KW - phosphorylation
KW - DARPP-32
KW - 1998
KW - Brain
KW - Cyclic Adenosine Monophosphate
KW - Dopamine
KW - Neural Receptors
KW - Phosphorylation
KW - Rats
KW - 1998
U1 - Sponsor: National Institutes of Health, US. Grant: MH10650. Recipients: Meredith, John M.
U1 - Sponsor: National Institutes of Health, US. Grant: HD08181. Recipients: Moffatt, Christopher A.
U1 - Sponsor: National Institutes of Health, US. Grant: MH11392. Recipients: Auger, Anthony P.
U1 - Sponsor: National Institutes of Health, US. Grant: MH 40899; DA 10044. Recipients: Greengard, Paul
U1 - Sponsor: National Institutes of Health, US. Grant: MH01312; NS19327. Recipients: Blaustein, Jeffrey D.
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Flynn, Michael R.
AU - Gatano, Betty L.
AU - McKernan, John L.
AU - Dunn, Kevin H.
AU - Blazicko, Brian A.
AU - Carlton, Gary N.
T1 - Modeling Breathing-Zone Concentrations of Airborne Contaminants Generated During Compressed Air Spray Painting.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 1999/01//
VL - 43
IS - 1
M3 - Article
SP - 67
EP - 76
SN - 00034878
AB - This paper presents a mathematical model to predict breathing-zone concentrations of airborne contaminants generated during compressed air spray painting in cross-flow ventilated booths. The model focuses on characterizing the generation and transport of overspray mist. It extends previous work on conventional spray guns to include exposures generated by HVLP guns. Dimensional analysis and scale model wind-tunnel studies are employed using non-volatile oils, instead of paint, to produce empirical equations for estimating exposure to total mass. Results indicate that a dimensionless breathing zone concentration is a nonlinear function of the ratio of momentum flux of air from the spray gun to the momentum flux of air passing through the projected area of the workers body. The orientation of the spraying operation within the booth is also very significant. The exposure model requires an estimate of the contaminant generation rate, which is approximated by a simple impactor model. The results represent an initial step in the construction of more realistic models capable of predicting exposure as a mathematical function of the governing parameters. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Atomization
KW - MATHEMATICAL models
KW - Mining engineering
KW - Cross-flow (Aerodynamics)
KW - Coating processes
KW - Air compressors
KW - Compressed air
KW - Industrial painting
KW - Consumption (Economics)
KW - Mathematical physics
KW - dimensional analysis
KW - exposure modeling
KW - spray-painting
KW - transfer efficiency
KW - ventilation
N1 - Accession Number: 44400010; Flynn, Michael R. 1; Gatano, Betty L. 2; McKernan, John L. 3; Dunn, Kevin H. 3; Blazicko, Brian A. 4; Carlton, Gary N. 4; Affiliations: 1: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599-7400, U.S.A.; 2: Department of Environment and Natural Resources, PO Box 27687, Raleigh, NC 16500, U.S.A.; 3: National Institute of Occupational Safety and Health, 4676 Columbia Parkway, M/S R5, Cincinnati, OH 45226, U.S.A.; 4: United States Air Force Armstrong Laboratory, Industrial Hygiene Branch, Brooks Air Force Base, San Antonio, TX 78235, U.S.A.; Issue Info: Jan1999, Vol. 43 Issue 1, p67; Thesaurus Term: Atomization; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: Mining engineering; Subject Term: Cross-flow (Aerodynamics); Subject Term: Coating processes; Subject Term: Air compressors; Subject Term: Compressed air; Subject Term: Industrial painting; Subject Term: Consumption (Economics); Subject Term: Mathematical physics; Author-Supplied Keyword: dimensional analysis; Author-Supplied Keyword: exposure modeling; Author-Supplied Keyword: spray-painting; Author-Supplied Keyword: transfer efficiency; Author-Supplied Keyword: ventilation; NAICS/Industry Codes: 333910 Pump and compressor manufacturing; NAICS/Industry Codes: 333912 Air and Gas Compressor Manufacturing; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 238320 Painting and Wall Covering Contractors; NAICS/Industry Codes: 325510 Paint and Coating Manufacturing; Number of Pages: 10p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107181436
T1 - Nursing centers and health promotion: a Federal vantage point.
AU - Clear JB
AU - Starbecker MM
AU - Kelly DW
Y1 - 1999/01//
N1 - Accession Number: 107181436. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 7809641.
KW - Community Health Nursing
KW - Health Promotion
KW - Health Education
KW - Health Services Accessibility
KW - Nursing Practice
KW - Community-Institutional Relations
KW - Healthy People 2000
KW - Cultural Competence
SP - 1
EP - 14
JO - Family & Community Health
JF - Family & Community Health
JA - FAM COMMUNITY HEALTH
VL - 21
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - For more than 50 years, the Division of Nursing has supported innovative initiatives to improve nursing practice, increase the knowledge and skills of nursing personnel, enhance their effectiveness in the delivery of health care across health care settings, and increase the number of qualified professional nurses. Nursing centers are funded through Special Project Grants and Contracts authorized under section 820 (b) of the Public Health Service Act. The grants are targeted to establish or expand nursing centers for the purpose of demonstrating methods to improve access to primary health care in medically underserved communities. Nursing centers provide faculty, staff, and students with unique opportunities to plan, implement, and evaluate nursing services, including primary health care and health promotion services that draw on the health promotion knowledge and skills integrated throughout didactic and clinical courses. Each project demonstrates the relationship of nursing center services to Healthy People 2000 objectives. The scope of services available through nursing centers addresses diverse needs of diverse populations across the entire life span. This article describes the success of nursing centers as models of population-based, nurse practice arrangements in communities where faculty and staff provide students with opportunities to incorporate such concepts as health promotion, public health, community, and advanced practice in preparation for expanded roles in meeting unmet health care needs outside of hospitals. Copyright (c) 1999 by Aspen Publishers, Inc.
SN - 0160-6379
AD - US Public Health Service, Division of Medicine, Health Resources and Services Administration, US Dept of Health and Human Services, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, John E.
AU - Wilson, Ronald
AU - Doll, Lynda
AU - Jones, T. Stephen
AU - Barker, Peggy
T1 - Condom Use and HIV Risk Behaviors Among U.S. Adults: Data from a National Survey.
JO - Family Planning Perspectives
JF - Family Planning Perspectives
Y1 - 1999/01//Jan/Feb99
VL - 31
IS - 1
M3 - Article
SP - 24
EP - 28
PB - Guttmacher Institute, Inc.
SN - 00147354
AB - Context: How much condom use among U.S. adults varies by type of partner or by risk behavior is unclear. Knowledge of such differentials would aid in evaluating the progress being made toward goals for levels of condom use as part of the Healthy People 2000 initiative. Methods: Data were analyzed from the 1996 National Household Survey of Drug Abuse, an annual household-based probability sample of the noninstitutionalized population aged 12 and older that measures the use of illicit drugs, alcohol and tobacco. The personal behaviors module included 25 questions covering sexual activity in the past year, frequency of condom use in the past year, circumstances of the last sexual encounter and HIV testing. Results: Sixty-two percent of adults reported using a condom at last intercourse outside of an ongoing relationship, while only 19% reported using condoms when the most recent intercourse occurred within a steady relationship. Within ongoing relationships, condom use was highest among respondents who were younger, black, of lower income and from large metropolitan areas. Forty percent of unmarried adults used a condom at last sex, compared with the health objective of 50% for the year 2000. Forty percent of injecting drug users used condoms at last intercourse, compared with the 60% condom use objective for high-risk individuals. Significantly, persons at increased risk for HIV because of their sexual behavior or drug use were not more likely to use condoms than were persons not at increased risk; only 22% used condoms during last intercourse within an ongoing relationship. Conclusions: Substantial progress has been made toward national goals for increasing condom use. The rates of condom use by individuals at high risk of HIV need to be increased, however, particularly condom use with a steady partner. [ABSTRACT FROM AUTHOR]
AB - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONDOMS
KW - ADULTS
KW - HIV (Viruses)
KW - RISK-taking (Psychology)
KW - SEXUAL intercourse
KW - UNITED States
N1 - Accession Number: 1657105; Anderson, John E. 1; Wilson, Ronald; Doll, Lynda 2; Jones, T. Stephen 3; Barker, Peggy 4; Source Information: Jan/Feb99, Vol. 31 Issue 1, p24; Subject: CONDOMS; Subject: ADULTS; Subject: HIV (Viruses); Subject: RISK-taking (Psychology); Subject: SEXUAL intercourse; Geographic Terms: UNITED States; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 5705
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107172323
T1 - Nursing and the uniformed services: an overview of the U.S. Public Health Service.
AU - Mazzella RB
Y1 - 1999/01//1999 Jan
N1 - Accession Number: 107172323. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 0163356.
KW - National Health Service Corps
KW - Advanced Nursing Practice
KW - Goals and Objectives
KW - Nurse Practitioners
KW - Personnel Recruitment
KW - Medically Underserved Area
KW - United States Public Health Service
KW - Male
KW - Female
SP - 47
EP - 49
JO - Imprint (00193062)
JF - Imprint (00193062)
JA - IMPRINT
VL - 46
IS - 1
CY - Brooklyn, New York
PB - National Student Nurses Association
SN - 0019-3062
AD - U.S. Public Health Service, Washington, DC
U2 - PMID: 10214156.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107172323&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - THES
ID - 109874327
T1 - Instructional methods for neuroscience in nurse anesthesia graduate programs: a survey of educational programs.
AU - Sanchez MR
Y1 - 1999/01//
N1 - Accession Number: 109874327. Language: English. Entry Date: 20010504. Revision Date: 20150923. Publication Type: Masters Thesis; research.
KW - Neurosciences -- Education
KW - Education, Nurse Anesthesia
KW - Curriculum
KW - Descriptive Research
KW - Surveys
KW - Content Validity
KW - Reliability
KW - Descriptive Statistics
KW - Human
SP - 91 p
EP - 91 p
JO - Instructional Methods for Neuroscience in Nurse Anesthesia Graduate Programs: A Survey of Educational Programs
JF - Instructional Methods for Neuroscience in Nurse Anesthesia Graduate Programs: A Survey of Educational Programs
PB - Uniformed Services University of the Health Sciences
AB - Advanced neuroscience instruction is a requirement for certification as a nurse anesthetist. The importance of learning neuroscience for the nurse anesthetist is reflected through the required hours determined by the Council of Accreditation of Nurse Anesthesia Educational Programs. Thirty percent of the certification examination relates to neuroscience. There are currently no studies in the literature describing instructional methods in neuroscience for nurse anesthesia programs. This study provides a descriptive analysis on how neuroscience is taught in accredited nurse anesthesia programs. A survey consisting of 29 questions regarding neuroscience course curriculum was mailed to the nurse anesthesia programs (n=83) accredited by the Council on Accreditation. Supporting evidence for content validity and reliability was obtained prior to the mailing. A total of 54 programs (64%) responded to the survey. The majority of the programs (51%) teach a specific course in neuroscience. The mean number of semester hours was (3.6 hours). The mean hours spent in lecture was 5 hours per week. The mean hours spent in the laboratory was 1 hour. Variability existed in the methods used for instruction. Textbooks were used on the average 33 % of the time teaching neuroscience. Lectures were used on the average 47 % of the time to teach neuroscience. Computer-aided instruction was used approximately 1% of the time to teach neuroscience. Clinical experience accounted for 10% of the instruction time to teach neuroscience. Laboratory time accounted for 1% and 'other' for 2% of the time.
AV - Order Info: 1399536
M1 - MSN
AD - United States Public Health Service Nurse Corps
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109874327&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107182713
T1 - An evaluation of the incidence of work-related asthma in the United States.
AU - Henneberger PK
AU - Kreiss K
AU - Rosenman KD
AU - Reilly MJ
AU - Chang Y
AU - Geidenberger CA
Y1 - 1999/01//1999 Jan-Mar
N1 - Accession Number: 107182713. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Asthma -- Epidemiology -- United States
KW - Occupational Diseases -- Epidemiology -- United States
KW - Epidemiological Research
KW - Michigan
KW - Data Analysis, Statistical
KW - Data Analysis Software
KW - P-Value
KW - United States
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Human
SP - 1
EP - 8
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 5
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The objective of the study was to estimate the incidences of physician-diagnosed cases of work-related asthma (WRA) in Michigan and the entire United States. The statewide surveillance system for WRA in Michigan receives reports primarily from three sources: physicians, hospital discharge data, and worker's compensation claims. Knowledge of the overlap in reports from these sources was used in conjunction with capture-recapture methods to estimate the total number of diagnosed cases of WRA, and incidence rates were calculated using the estimated number of civilian employees in Michigan as the population at risk. For the entire United States, the product of a national incidence rate for asthma among adults and estimates of the proportion that is work-related was used. A total of 933 cases of WRA were reported to the Michigan surveillance program during 1988-1995, of which 904 were reported by at least one of the three main sources and equaled an average incidence of 27 cases/10(6)/year. This estimate was less than the range of estimates 58 to 204 cases/10(6)/year in Michigan arrived at using the capture-recapture methods. The national estimates of WRA ranged from 63 to 441 cases/10(6)/year. The authors' indirect estimates are closer to estimates from Canada, Sweden, and Finland than most existing direct estimates in the United States, but probably still underestimates the magnitude of WRA incidence because of the limitations of physician recognition of the work-relatedness of asthma among adults.
SN - 1077-3525
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 10092740.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107182713&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107182721
T1 - Education and practice. Surveillance and occupational health.
AU - Fine LJ
Y1 - 1999/01//1999 Jan-Mar
N1 - Accession Number: 107182721. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Disease Surveillance
KW - Occupational Diseases -- Epidemiology
KW - Occupational-Related Injuries -- Epidemiology
KW - Occupational Hazards -- Epidemiology
KW - Occupational Exposure -- Epidemiology
SP - 26
EP - 29
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 5
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This report explains the basics of two important uses of surveillance data: determining the magnitude of a specific occupational health or injury problem and examining temporal trends to determine whether the problem is increasing or decreasing. Types of data available for the purpose and some of their strengths and weaknesses are described. The utility of surveillance data is illustrated with examples from surveillance of acute injuries, musculoskeletal disorders, lead overexposures, and hazard surveillance data sets. Increasingly, surveillance systems may be used to evaluate the effectiveness of interventions. Surveillance is most important in times of rapid change in the economy and when resources for prevention may be limited. Both conditions are common in the world today.
SN - 1077-3525
AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
U2 - PMID: 10092744.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107189244
T1 - 1998 ASHT Presidential address. The truth is not negotiable: we can make a difference.
AU - Bell-Krotoski J
Y1 - 1999/01//1999 Jan-Mar
N1 - Accession Number: 107189244. Language: English. Entry Date: 19990501. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8806591.
KW - Specialties, Allied Health
KW - Hand Injuries -- Rehabilitation
SP - 3
EP - 6
JO - Journal of Hand Therapy
JF - Journal of Hand Therapy
JA - J HAND THER
VL - 12
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0894-1130
AD - Chief, Hand and Occupational Therapy, Rehabilitation Research Dept, United States Public Health Service, Gillis W Long Hansen's Disease Center, Carville, LA 70721
U2 - PMID: 10192629.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107189244&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - Keynote Address.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 225S
EP - 226S
SN - 00223166
N1 - Accession Number: 96710957; Woodcock, Janet 1; Affiliations: 1: Center for Drugs, Food and Drug Administration, Rockville, Maryland 20852; Issue Info: Jan99, Vol. 129 Issue 1, p225S; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mann, Marianne
T1 - Approved Pharmacologic Interventions for Wasting: An Overview and Lessons Learned.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 303S
EP - 305S
SN - 00223166
N1 - Accession Number: 96710986; Mann, Marianne 1; Affiliations: 1: Division of Reproductive and Urologic Drug Products, Food and Drug Administration, Rockville, MD 20857; Issue Info: Jan99, Vol. 129 Issue 1, p303S; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Senior, John R.
AU - Maroni, Bradley J.
T1 - Working Group Session Report: Chronic Renal and Gastrointestinal Disease.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 313S
EP - 314S
SN - 00223166
N1 - Accession Number: 96710994; Senior, John R. 1; Maroni, Bradley J. 2; Affiliations: 1: Gastrointestinal Division, Food and Drug Administration, Rockville, Maryland 20857; 2: Renal Division, Emory University, Atlanta, Georgia 30322; Issue Info: Jan99, Vol. 129 Issue 1, p313S; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107188777
T1 - The epidemiology and control of communicable diseases (in the outpatient setting)
AU - Willy ME
Y1 - 1999/01//1999 Jan-Feb
N1 - Accession Number: 107188777. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9706704.
KW - Communicable Diseases -- Epidemiology
KW - Communicable Diseases -- Prevention and Control
KW - Child
KW - Antibiotic Prophylaxis
KW - Postexposure Follow-Up
KW - Primary Health Care
KW - Community-Acquired Infections -- Prevention and Control
KW - Disease Transmission -- Prevention and Control -- In Infancy and Childhood
KW - Chickenpox -- Prevention and Control
KW - Measles -- Prevention and Control
KW - Tuberculosis, Pulmonary -- Prevention and Control
KW - Mycobacterium Tuberculosis
KW - Hepatitis B -- Prevention and Control
KW - HIV Infections -- Prevention and Control
KW - Bloodborne Pathogens
SP - 82
EP - 92
JO - Lippincott's Primary Care Practice
JF - Lippincott's Primary Care Practice
JA - LIPPINCOTTS PRIM CARE PRACT
VL - 3
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1088-5471
AD - Center for Drug Evaluation and Research, Food and Drug Administration, MSP HFD733, 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 10214208.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107164425
T1 - Device safety. Collagen hemostasis devices.
AU - Gallauresi BA
Y1 - 1999/01//
N1 - Accession Number: 107164425. Language: English. Entry Date: 19990201. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Hemostatic Techniques -- Equipment and Supplies
KW - Hemostatic Techniques -- Adverse Effects
KW - Equipment Safety
KW - Hematoma -- Etiology
KW - Nursing Assessment
KW - Monitoring, Physiologic
KW - Femoral Artery
KW - Aged
KW - Male
SP - 31
EP - 31
JO - Nursing
JF - Nursing
JA - NURSING
VL - 29
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health Food and Drug Administration, Rockville, Md
U2 - PMID: 9987294.
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DP - EBSCOhost
DB - rzh
ER -
TY - THES
ID - 109874338
T1 - Suicide in the U.S. federal prison system: a study of high-risk variables.
AU - Frickey RC
Y1 - 1999/01//
N1 - Accession Number: 109874338. Language: English. Entry Date: 20010504. Revision Date: 20150923. Publication Type: Masters Thesis; research.
KW - Suicide
KW - Prisoners
KW - Risk Factors
KW - Correctional Facilities
KW - Conceptual Framework
KW - Suicide -- Psychosocial Factors
KW - Record Review
KW - Human
SP - 47 p
EP - 47 p
JO - Suicide in the U.S. Federal Prison System: A Study of High-risk Variables
JF - Suicide in the U.S. Federal Prison System: A Study of High-risk Variables
PB - Uniformed Services University of the Health Sciences
AB - This study examined the relationship between demographic traits of inmates in U.S. Federal prisons, and the commission of suicide from the time period 1993-97. A comparison was made to previous studies of two earlier 5-year periods. A stress adaptation model of nursing care was adopted for the purpose of providing a conceptual framework for the study, and the primary method of data collection employed was a chart review. Data surrounding the event of suicide was extracted from 61 inmate records, representing 100% of all suicides occurring during the five-year period of the study. Data was examined through the use of a tool used in previous research called the 'psychological autopsy'. The results of the study were found to be similar to those of previous studies, and were demonstrated in an updated inmate profile which delineates common risk factors for suicide in this correctional setting. Results of this study confirm the effectiveness of suicide prevention programs in place within the Federal Bureau of Prisons. Recommendations for the future included the increased utilization of mid-level practitioners to identify inmates at high risk for suicide, a critical look at the physical environment in which the suicides take place, and the continuation of an on-going, systematic approach to the problem of inmate suicide in the correctional setting.
AV - Order Info: 1699509
M1 - MSN
AD - United States Public Health Service Nurse Corps
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Garry, V.F.
AU - Burroughs, B.
AU - Tarone, R.
AU - Kesner, J.S.
T1 - Herbicides and adjuvants: an evolving view.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/01//
VL - 15
IS - 1/2
M3 - Article
SP - 159
EP - 167
PB - Sage Publications, Ltd.
SN - 07482337
AB - The present report examines the in vitro genotoxicity (micronucleus assay) of herbicides and adjuvants and reports on an in vivo human study on potential endocrine effects of pesticides, including herbicides. Adjuvants are used in conjunction with 2,4-dichlorophenoxy acetic acid (2,4-D) and other herbicides. Earlier pesticide applier survey results (n=709) show that 59% of the applicators used adjuvants, and the majority of this group used paraffinic oils and/or surfactant mixtures. As a beginning effort to explore the role of adjuvants and herbicides in hormonally based reproductive effects, a prospective, controlled study was performed to analyze blood specimens from three different exposure groups (applicators using herbicides only; applicators using both herbicides and insecticides; and applicators using fumigants in addition to herbicides and insecticides; and a control group composed of other agricultural workers including organic farmers). The applicators and controls were age- and smoking-matched. Study subjects (n=78) were tested before, during, and after completion of pesticide application season for the effects of pesticide products on hormone levels in the bloodstream. Of the applicator exposure groups examined, only the herbicide group showed significant endocrinologic differences from controls. Free testosterone levels were significantly elevated in post-season measurements (p=0.032), and follicle-stimulating hormone (FSH) was significantly decreased at the height of the season (p=0.016) and in the post-season (p=0.010) as compared to controls. These endocrinologic findings are discussed in terms of their possible relationship to potential endocrine effects of herbicides, herbicide contaminants, and adjuvants. In vitro genotoxicity examination compared four different commercially available surfactant mixtures with 12 different commercial herbicide products, including six different chlorophenoxy herbicides. Only one herbicide yielded a significant dose–response curve. All four adjuvants showed positive dose–response effects. These preliminary data suggest that adjuvants are not inert but are toxicologically active components added to herbicide mixtures. Whether adjuvant toxicant effects are additive or are independent of herbicide effects is poorly understood. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Herbicides
KW - Genetic toxicology
KW - Pesticides
KW - Immunological adjuvants
KW - adjuvants
KW - herbicides
KW - hormone analysis
KW - human study
KW - Micronucleus assay
N1 - Accession Number: 4745647; Garry, V.F. 1; Burroughs, B. 1; Tarone, R. 2; Kesner, J.S. 3; Affiliations: 1: University of Minnesota, Environmental Medicine and Pathology Program, Minneapolis, Minnesota; 2: National Cancer Institute, Epidemiology and Biostatistics Program, Bethesda, Maryland; 3: National Institute for Occupational Safety and Health, Experimental Toxicology Branch, Cincinnati, Ohio; Issue Info: 1999, Vol. 15 Issue 1/2, p159; Thesaurus Term: Herbicides; Thesaurus Term: Genetic toxicology; Thesaurus Term: Pesticides; Subject Term: Immunological adjuvants; Author-Supplied Keyword: adjuvants; Author-Supplied Keyword: herbicides; Author-Supplied Keyword: hormone analysis; Author-Supplied Keyword: human study; Author-Supplied Keyword: Micronucleus assay; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1998-11938-001
AN - 1998-11938-001
AU - Clear, Janet B.
AU - Starbecker, Marcia Marlow
AU - Kelly, David W.
T1 - Nursing centers and health promotion: A federal vantage point.
JF - Family & Community Health: The Journal of Health Promotion & Maintenance
JO - Family & Community Health: The Journal of Health Promotion & Maintenance
JA - Fam Community Health
Y1 - 1999/01//
VL - 21
IS - 4
SP - 1
EP - 14
CY - US
PB - Lippincott Williams & Wilkins
SN - 0160-6379
SN - 1550-5057
N1 - Accession Number: 1998-11938-001. Partial author list: First Author & Affiliation: Clear, Janet B.; US Public Health Service, Div of Medicine, US. Release Date: 19990201. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Health Promotion; Nursing; Public Health Services. Minor Descriptor: Community Health. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 14. Issue Publication Date: Jan, 1999.
AB - Nursing centers provide faculty, staff, and students with unique opportunities to plan, implement, and evaluate nursing services, including primary health care and health promotion services that draw on the health promotion knowledge and skills integrated throughout didactic and clinical courses. Each project demonstrates the relationship of nursing center services to Healthy People 2000 objectives. The scope of services available through nursing centers addresses diverse needs of diverse populations across the entire life span. This article describes the success of nursing centers as models of population-based, nurse practice arrangements in communities where faculty and staff provide students with opportunities to incorporate such concepts as health promotion, public health, community, and advanced practice in preparation for expanded roles in meeting unmet health care needs outside of hospitals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - federal nursing centers & community health promotion
KW - 1999
KW - Community Services
KW - Health Promotion
KW - Nursing
KW - Public Health Services
KW - Community Health
KW - 1999
DO - 10.1097/00003727-199901000-00003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1998-11938-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1999-11582-005
AN - 1999-11582-005
AU - Martinelli, Angela Maria
T1 - Testing a model of avoiding environmental tobacco smoke in young adults.
JF - IMAGE: Journal of Nursing Scholarship
JO - IMAGE: Journal of Nursing Scholarship
JA - Image J Nurs Sch
Y1 - 1999///
VL - 31
IS - 3
SP - 237
EP - 242
CY - United Kingdom
PB - Blackwell Publishing
SN - 0743-5150
N1 - Accession Number: 1999-11582-005. PMID: 10528453 Other Journal Title: Journal of Nursing Scholarship. Partial author list: First Author & Affiliation: Martinelli, Angela Maria; US Public Health Service, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20000101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Environmental Stress; Health Behavior; Human Sex Differences; Self-Efficacy; Social Environments. Minor Descriptor: College Students; Passive Smoking; Social Influences. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study. Page Count: 6. Issue Publication Date: 1999.
AB - Examined contributing factors for college students avoiding environmental tobacco smoke (ETS), and tested an explanatory model. Ss in the 1995 study were 136 volunteer non-smoking college students (aged 18–25 yrs) from a mid-Atlantic private US university, drawn from a sample of 241 smokers and non-smokers. Administered tests included the General Self-Efficacy Scale, the Health Promotion Lifestyle Profile, and the ETS Avoidance Scale. Regression analyses showed that 26% of variance in avoiding ETS was accountable to gender, self-efficacy possession, ETS-avoidance efficacy, and not residing with smokers. Performing other healthy behaviors was the most significant factor. It is concluded that enhancing self-efficacy and encouraging healthy lifestyle behaviors may be an important means to promote the avoidance of ETS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender & self efficacy & situational influences & health behaviors
KW - avoidance of environmental tobacco smoke exposure
KW - college students
KW - 1999
KW - Environmental Stress
KW - Health Behavior
KW - Human Sex Differences
KW - Self-Efficacy
KW - Social Environments
KW - College Students
KW - Passive Smoking
KW - Social Influences
KW - 1999
DO - 10.1111/j.1547-5069.1999.tb00487.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1999-11582-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1999-01444-008
AN - 1999-01444-008
AU - Kolbe, Lloyd J.
AU - Talley, Ronda C.
AU - Short, Rick Jay
T1 - Integrating education, health and social services for young people: Current status and future directions.
T3 - Integrating education, health, and social services for young people
JF - Journal of Educational & Psychological Consultation
JO - Journal of Educational & Psychological Consultation
JA - J Educ Psychol Consult
Y1 - 1999///
VL - 10
IS - 3
SP - 297
EP - 313
CY - US
PB - Lawrence Erlbaum
SN - 1047-4412
SN - 1532-768X
N1 - Accession Number: 1999-01444-008. Partial author list: First Author & Affiliation: Kolbe, Lloyd J.; US Public Health Service, Ctrs for Disease Control & Prevention, Div of Adolescent & School Health, Atlanta, GA, US. Other Publishers: Taylor & Francis. Release Date: 20000201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Education; Government Policy Making; Health Care Services; Integrated Services; Social Services. Minor Descriptor: Student Personnel Services. Classification: Community & Social Services (3373). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 17. Issue Publication Date: 1999.
AB - Highlights some recent national developments and resources and presents 6 means that can be used to improve the integration of education, health, and social services for young people. The 6 means to improve service integration include: (1) theory, (2) support, (3) evaluation, (4) indicators, (5) training, and (6) infrastructure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - national developments & resources & means to improve integration of education & health & social services for young people
KW - 1999
KW - Education
KW - Government Policy Making
KW - Health Care Services
KW - Integrated Services
KW - Social Services
KW - Student Personnel Services
KW - 1999
DO - 10.1207/s1532768xjepc1003_8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=1999-01444-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Szücs, G
AU - Új, M
AU - Mihály, I
AU - Deák
T1 - Burden of human rotavirus-associated hospitalizations in three geographic regions of Hungary.
JO - Acta Paediatrica. Supplement
JF - Acta Paediatrica. Supplement
Y1 - 1999/01/02/Jan99 Supplement 426
VL - 88
IS - s426
M3 - Article
SP - 61
EP - 65
SN - 08035326
AB - Data on hospital admissions and laboratory reports were used to estimate the number of hospitalizations of children aged 14 y or less in three geographic regions of Hungary due to group A rotavirus infection. Between January 1993 and December 1996, 9182 hospitalizations for gastroenteritis occurred, of which 1946 (21%) were associated with rotavirus infection. Most (90%) ofthe rotavirus detections were among children aged 4 y or less. By extrapolation, an estimated 5000 rotavirus-related hospitalizations (8.4/1000 children aged 4 y or less/y) occurred in Hungary during the study period. Marked seasonality of rotavirus infections was observed, with a peak of incidence from December to February. Rotaviruses with 'long' RNA electropherotypes predominated each year, but in 1995/1996 20% of electropherotypes in the Budapest area were 'short'. Effective surveillance is required for all children hospitalized for diarrhoea as part of a rotavirus immunization program in Hungary. □ Age group, burden, electropherotypes, Hungaiy, region, rotavirus, season [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Paediatrica. Supplement is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - HOSPITAL care
KW - INFECTION in children
KW - DIARRHEA in children
KW - IMMUNIZATION of children
KW - HUNGARY
N1 - Accession Number: 63460707; Szücs, G 1; Új, M 1; Mihály, I 2; Deák 3; Source Information: Jan99 Supplement 426, Vol. 88 Issue s426, p61; Subject: ROTAVIRUSES; Subject: HOSPITAL care; Subject: INFECTION in children; Subject: DIARRHEA in children; Subject: IMMUNIZATION of children; Geographic Terms: HUNGARY; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1651-2227.1999.tb14328.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=63460707&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107079080
T1 - The National Organ and Tissue Donation Initiative: working together to save lives.
AU - Thurm K
Y1 - 1999/01/04/
N1 - Accession Number: 107079080. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9703530.
KW - Organ Procurement
KW - Emergency Medical Services
SP - 369
EP - 370
JO - Prehospital Emergency Care
JF - Prehospital Emergency Care
JA - PREHOSPITAL EMERG CARE
VL - 3
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1090-3127
AD - US Department of Health and Human Services, Washington, DC
U2 - PMID: 10534044.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107079080&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107003000
T1 - Therapeutic selection during an emergency response.
AU - Montello MJ
AU - Ames T
Y1 - 1999/02//1999 Feb 1
N1 - Accession Number: 107003000. Language: English. Entry Date: 20010302. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Disasters
KW - Drug Therapy
KW - Pharmacists
KW - Drugs, Prescription -- Administration and Dosage
KW - Emergency Care
KW - Patient Assessment
SP - 236
EP - 240
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 56
IS - 3
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Deputy-Chief Pharmacy Officer, Disaster Medical Assistance Team-1, U.S. Public Health Service, Bethesda, MD
U2 - PMID: 10030508.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107003000&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ambrosone, Christine B.
AU - Coles, Brian F.
AU - Freudenheim, Jo L.
AU - Shields, Peter G.
T1 - Glutathione-S-transferase (GSTM1) Genetic Polymorphisms Do Not Affect Human Breast Cancer Risk, Regardless of Dietary Antioxidants.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/02//
VL - 129
IS - 2
M3 - Article
SP - 565S
EP - 568S
SN - 00223166
AB - Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of a-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - antioxidants
KW - breast neoplasms
KW - epidemiology/molecular
KW - glutathione-S-transferase
KW - oxidative stress
N1 - Accession Number: 96711791; Ambrosone, Christine B. 1; Coles, Brian F. 1; Freudenheim, Jo L. 2; Shields, Peter G. 3; Affiliations: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079; 2: Department of Social & Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214; 3: Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892; Issue Info: Feb99, Vol. 129 Issue 2, p565S; Author-Supplied Keyword: antioxidants; Author-Supplied Keyword: breast neoplasms; Author-Supplied Keyword: epidemiology/molecular; Author-Supplied Keyword: glutathione-S-transferase; Author-Supplied Keyword: oxidative stress; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
T1 - LETTERS TO THE EDITOR.
AU - Jacobson, Elizabeth D.
AU - Shein, Mitchell J.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 1999/02//
VL - 22
IS - 2
SP - 400
EP - 401
SN - 01478389
N1 - Accession Number: 17124042; Author: Jacobson, Elizabeth D.: 1 Author: Shein, Mitchell J.: 2 ; Author Affiliation: 1 Deputy Director for Science Center for Devices and Radiological Health: 2 FDA Expert, Clinical Cardiac Pacing Center for Devices and Radiological Health; No. of Pages: 2; Language: English; Publication Type: Letter; Update Code: 20050525
N2 - Presents a letters to the editor about cardiac pacemakers and defibrillator operation by electromagnetic fields.
KW - *CARDIAC pacemakers
KW - LETTERS to the editor
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=17124042&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107179053
T1 - Evaluation of the revised NIOSH lifting equation: a cross-sectional epidemiologic study...including commentary by Andersson GBJ
AU - Waters TR
AU - Baron SL
AU - Piacitelli LA
AU - Anderson VP
AU - Skov T
AU - Haring-Sweeney M
AU - Wall DK
AU - Fine LJ
Y1 - 1999/02/15/1999 Feb 15
N1 - Accession Number: 107179053. Language: English. Entry Date: 19990401. Revision Date: 20150711. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7610646.
KW - Lifting
KW - Low Back Pain -- Epidemiology
KW - Instrument Validation
KW - Cross Sectional Studies
KW - Epidemiological Research
KW - National Institute for Occupational Safety and Health
KW - Observational Methods
KW - Interviews
KW - Repeated Measures
KW - Risk Assessment
KW - Questionnaires
KW - Logistic Regression
KW - Odds Ratio
KW - Data Analysis, Computer Assisted
KW - Factor Analysis
KW - Descriptive Statistics
KW - P-Value
KW - Confidence Intervals
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 386
EP - 395
JO - Spine (03622436)
JF - Spine (03622436)
JA - SPINE
VL - 24
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - STUDY DESIGN: A cross-sectional study of the 1-year prevalence of low back pain was conducted in workers employed in manual lifting jobs. OBJECTIVES: To provide epidemiologic data to determine the correlation between the prevalence of low back pain and exposure to manual lifting stressors, measured with the lifting index component of the revised lifting equation from the National Institute for Occupational Safety and Health (NIOSH). SUMMARY OF BACKGROUND DATA: The NIOSH lifting equation has been proposed as a practical, yet valid tool for assessing the risks of low back pain caused by manual lifting. To date, however, there have been few studies in which the effectiveness of the equation to identify jobs with elevated rates of low back pain has been evaluated. METHODS: Fifty jobs from four industrial sites were evaluated with the NIOSH lifting equation. A symptom and occupational history questionnaire was administered to 204 people employed in lifting jobs and 80 people employed in nonlifting jobs. Regression analysis was used to determine whether there was a correlation between the lifting index and reported low back pain. RESULTS: As the lifting index increased from 1.0 to 3.0, the odds of low back pain increased, with a peak and statistically significant odds ratio occurring in the 2 < lifting index < or = 3 category (odds ratio = 2.45). For jobs with a lifting index higher than 3.0, however, the odds ratio was lower (odds ratio = 1.45). CONCLUSIONS: Although low back pain is a common disorder, the lifting index appears be a useful indicator for determining the risk of low back pain caused by manual lifting. Copyright (c) 1999, Lippincott-Raven Publishers. Reprinted from Spine by permission.
SN - 0362-2436
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio
U2 - PMID: 10065524.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107179053&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Misbin, R. I.;
T1 - Troglitazone-associated hepatic failure
CT - Troglitazone-associated hepatic failure
JO - Annals of Internal Medicine (USA)
JF - Annals of Internal Medicine (USA)
Y1 - 1999/02/16/
VL - 130
IS - Feb 16
SP - 330
SN - 00034819
AD - U.S. Food and Drug Administration, Rockville, MD, 20857 USA
N1 - Accession Number: 37-00073; Language: English; Trade Name: Rezulin; Generic Name: Troglitazone; Chemical Name: Troglitazone--97322-87-7 Troglitazone--97322-87-7; References: 5; Publication Type: Letters; Journal Coden: AIMEAS; Human Indicator: Yes; Section Heading: Toxicity; Drug EvaluationsLegislation, Laws and Regulations; Abstract Author: Ramune T. Dailide
N2 - The monitoring of alanine aminotransferase serum levels to prevent liver failure in patients with diabetes mellitus receiving troglitazone (Rezulin) and labeling changes by the manufacturer of troglitazone regarding the monitoring of this agent following the reporting of 24 cases of troglitazone-associated liver failure are discussed.
KW - Troglitazone--toxicity-;
KW - Antidiabetic agents--troglitazone--toxicity monitoring;
KW - Diabetes mellitus--troglitazone--toxicity monitoring;
KW - Liver failure--troglitazone--toxicity;
KW - Toxicity--troglitazone--monitoring;
KW - Labeling--troglitazone--toxicity monitoring;
KW - Industry, pharmaceutical--troglitazone--labeling;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Will, Julie C.
AU - Denny, Clark
AU - Serdula, Mary
AU - Muneta, Ben
T1 - Trends in Body Weight Among American Indians: Findings From a Telephone Survey, 1985 Through 1996.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/03//
VL - 89
IS - 3
M3 - Article
SP - 395
EP - 398
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study compared trends in body mass index for American Indian men and women across selected regions of the United States. Methods. Self-reported data were collected from the Behavioral Risk Factor Surveillance System. Results. Among women in the Dakotas, New Mexico and Arizona. and Washington and Oregon, average adjusted body mass index increased significantly by 0.1 to 0.2 units per year. Among men in Alaska and the Dakotas, average adjusted body mass index also increased significantly by 0.1 to 0.2 units each year. Conclusions. Because of rapid increases in average body mass index, some American indian populations could be burdened by an increased incidence of chronic disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Body mass index
KW - Native Americans
KW - Telephone surveys
KW - Body weight
KW - Chronic diseases
KW - United States
N1 - Accession Number: 1606381; Will, Julie C. 1; Email Address: jxw6@cdc.gov; Denny, Clark 1; Serdula, Mary 1; Muneta, Ben 2; Affiliations: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga.; 2: Epidemiology Program, Headquarters West, Indian Health Service, Albuquerque, NM; Issue Info: Mar1999, Vol. 89 Issue 3, p395; Subject Term: Body mass index; Subject Term: Native Americans; Subject Term: Telephone surveys; Subject Term: Body weight; Subject Term: Chronic diseases; Subject: United States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107188080
T1 - Irrigation with antimicrobial agents for the treatment of periodontitis -- is it effective?
AU - Gustke CJ
Y1 - 1999/03//1999 Mar-Apr
N1 - Accession Number: 107188080. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7610466.
KW - Periodontitis -- Drug Therapy
KW - Therapeutic Irrigation
KW - Iodine -- Therapeutic Use
KW - Chlorhexidine -- Therapeutic Use
KW - Literature Review
KW - Outcome Assessment
KW - Education, Continuing (Credit)
SP - 164
EP - 170
JO - General Dentistry
JF - General Dentistry
JA - GEN DENT
VL - 47
IS - 2
CY - Chicago, Illinois
PB - Academy of General Dentistry
SN - 0363-6771
AD - Navajo Area Indian Health Service, Gallup Indian Medical Center-Dental Clinic, 516 East Nizhoni Blvd., Gallup, NM 87301
U2 - PMID: 10687493.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107188080&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107189318
T1 - Commentary. Listen to the messages within your agency.
AU - Harrison PL
Y1 - 1999/03//1999 Mar
N1 - Accession Number: 107189318. Language: English. Entry Date: 19990501. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8403379.
KW - Home Health Agencies -- Administration
KW - Communication
SP - 200
EP - 200
JO - Home Healthcare Nurse
JF - Home Healthcare Nurse
JA - HOME HEALTHC NURSE
VL - 17
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0884-741X
AD - Washington County Public Health Service, Hudson Falls, New York
U2 - PMID: 10362967.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107189318&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107204496
T1 - Herpesvirus vaccines: development, controversies, and applications.
AU - Krause PR
AU - Straus SE
Y1 - 1999/03//1999 Mar
N1 - Accession Number: 107204496. Language: English. Entry Date: 19990801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8804508.
KW - Herpesvirus Infections -- Prevention and Control
KW - Viral Vaccines -- Immunology
KW - Herpesviruses -- Immunology
KW - Herpesvirus Infections -- Classification
SP - 61
EP - 81
JO - Infectious Disease Clinics
JF - Infectious Disease Clinics
JA - INFECT DIS CLIN NORTH AM
VL - 13
IS - 1
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Herpesviruses present difficult challenges in vaccine development because of their ability to evade immune clearance. Data and recommendations regarding the live-attenuated varicella vaccine are discussed. Approaches to developing vaccines to prevent herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV)-associated illnesses also are considered. Copyright (c) 1999 by W.B. Saunders Company
SN - 0891-5520
AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, Maryland
U2 - PMID: 10198792.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107204496&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dixon, Lisa
AD - Center for Mental Health Services Research, U MD
T1 - Providing Services to Families of Persons with Schizophrenia: Present and Future
JO - Journal of Mental Health Policy and Economics
JF - Journal of Mental Health Policy and Economics
Y1 - 1999/03//
VL - 2
IS - 1
SP - 3
EP - 8
SN - 10914358
N1 - Accession Number: 0627403; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200211
N2 - The important role of families and other caregivers in the lives of adults with schizophrenia is well documented. Persons with schizophrenia frequently live with their families of origin, and the vast majority have regular family contact. Families of persons with schizophrenia have also been demonstrated to have significant needs. Families most frequently cite the need for education and support in helping them to cope with their family member's illness. Further, numerous studies have documented the benefits of interventions designed to meet the needs of family members. This paper identifies critical issues and challenges in the provision of services to families of persons with schizophrenia and other serious and persistent mental illnesses.
KW - Analysis of Health Care Markets I11
L3 - http://www.icmpe.org/test1/journal/journal.htm
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0627403&site=ehost-live&scope=site
UR - http://www.icmpe.org/test1/journal/journal.htm
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Roe, Brian
AU - Levy, Alan S.
AU - Derby, Brenda M.
T1 - The Impact of Health Claims on Consumer Search and Product Evaluation Outcomes: Results from FDA Experimental Data.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1999///Spring99
VL - 18
IS - 1
M3 - Article
SP - 89
EP - 105
PB - American Marketing Association
SN - 07439156
AB - The authors report results of a mall-intercept study regarding the effects of health claims on consumer information search and processing behavior. Results suggest that the presence of health and nutrient-content claims on food packages induces respondents to truncate information search to the front panel of packages. Respondents who either truncate information search or view claims provide more positive summary judgments of products and give greater weight to the information mentioned in claims than to the information available in the Nutrition Facts panel. The presence of a claim also is associated with a halo effect (rating the product higher on other health attributes not mentioned in the claim) and, for one of the three products tested, a magic-bullet effect (attributing inappropriate health benefits to the product). The authors discuss the policy implications of these results for Food and Drug Administration health claim regulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Consumers
KW - Consumer behavior
KW - Food
KW - Drugs
KW - Packaging
KW - Health
KW - Health behavior
KW - Nutrition
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 1932040; Roe, Brian 1; Levy, Alan S. 2; Derby, Brenda M. 3; Affiliations: 1: Assistant Professor, Department of Agricultural Environment and Development Economics Ohio State University; 2: Chief Consumer Studies Branch, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; 3: Statistician. Consumer Studies Branch, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; Issue Info: Spring99, Vol. 18 Issue 1, p89; Thesaurus Term: Consumers; Thesaurus Term: Consumer behavior; Subject Term: Food; Subject Term: Drugs; Subject Term: Packaging; Subject Term: Health; Subject Term: Health behavior; Subject Term: Nutrition; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 17p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 107206619
T1 - Injury among cavers: results of a preliminary national survey.
AU - Ashford DA
AU - Knutson RS
AU - Sacks JJ
Y1 - 1999/03//1999 Mar
N1 - Accession Number: 107206619. Language: English. Entry Date: 19990801. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Continental Europe; Europe; Peer Reviewed. NLM UID: 0376337.
KW - Athletic Injuries -- Epidemiology
KW - Questionnaires
KW - Injury Pattern
KW - Sports Organizations
KW - Risk Factors
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 71
EP - 73
JO - Journal of Sports Medicine & Physical Fitness
JF - Journal of Sports Medicine & Physical Fitness
JA - J SPORTS MED PHYS FITNESS
VL - 39
IS - 1
PB - Edizioni Minerva Medica
AB - BACKGROUND: To estimate the frequency of and risk factors for caving-associated injuries. METHODS: A standardized questionnaire covering demographics, caving exposure, and injury history was distributed to all members of the National Speleological Society by inclusion in the monthly newsletter. RESULTS: Of 9,532 members sent a questionnaire, 301 responded (3.2%). Respondents had an average of 18 years of caving experience, and 37% had sustained one or more injuries while caving. Hypothermia was the most frequent injury, followed by fractures, animal bites, and concussions. The rate of injury was about 1 per 1,990 hours in a cave. Injury rates for females were about twice those of males; older persons and those with more than 5 years of caving experience seemed to have lower injury rates. CONCLUSIONS: Many caving injuries appear potentially preventable. Proper technique for safe climbing should be a part of exploration training. There is a need for proper belaying or rappelling for even short ascents or descents. Helmet use should be stressed, as should adequate protection from hypothermia.
SN - 0022-4707
AD - Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), US Department of Health and Human Services, US Public Health Service, Atlanta, GA
U2 - PMID: 10230173.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107198422
T1 - Clip & file. Dx-ray.
AU - Carlucci GJ
AU - Watkins DJ
Y1 - 1999/03//1999 Mar
N1 - Accession Number: 107198422. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8403486.
KW - Mercury -- Adverse Effects
KW - Substance Abuse, Intravenous -- Complications
KW - Diagnosis, Differential
KW - Radiography, Thoracic
KW - Adult
KW - Male
SP - 69
EP - 70
JO - Physician Assistant
JF - Physician Assistant
JA - PHYSICIAN ASSIST
VL - 23
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 8750-7544
AD - Department of Outpatient and Emergency Medicine, Indian Health Service Hospital, Crownpoint, NM
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schmued, Larry
AU - Slikker, William
AU - Clausing, Peter
AU - Bowyer, John
T1 - d-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/03//
VL - 48
IS - 1
M3 - Article
SP - 100
EP - 106
PB - Oxford University Press / USA
SN - 10966080
AB - d-Fenfluramine is a potent serotonin (5-HT) reuptake inhibitor/releaser and, until its recent recall, was prescribed as an anoretic agent. This study demonstrates that 10 mg/kg d-fenfluramine ip, when administered to rats in a warm (27°C) environment, produces neuronal degeneration within select brain regions. Degeneration was detected and localized using a recently developed flourescent marker of neuronal degeneration, Fluoro-Jade. The most extensive cortical damage was in the anterior cingulate region. In the medial thalamus, degeneration was frequently seen within the intralaminar nuclei, and somewhat less frequently observed within the paraventricular nucleus, the mediodorsal nucleus, and the gelatinosis nucleus. Cerebellar damage occurred primarily in medial Purkinje cells and occasionally in granule cells or basket cells. Degeneration was not observed in either saline-injected control animals or in rats given even higher doses of 25 mg/k d-fenfluramine but kept in a cooler environment (23°C). The degeneration was clearly most prominent in animals with body temperatures of 41° to 42°C, but this degeneration was not seen in animals given saline that became extremely hyperthermic in a 37°C environment. Behavioral signs such as tremors, myoclonus, rigidity, and splayed legs were seen in all animals with extensive neurodegeneration. The areas damaged by d-fenfluramine when hyperthermia occurs, could play a role in the expression of the serotonin syndrome. Elevated extracellular 5-HT levels alone are probably not sufficient for neurotoxicity, and additional factors such as hyperthermia, regional specificity of 5-HT receptor subtypes, blood flow, and or neuronal networks may be involved. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fenfluramine
KW - Serotonin uptake inhibitors
KW - Purkinje cells
KW - Neurons
KW - Fever
KW - anoretic
KW - anterior cingulate cortex
KW - dexfenfluramine
KW - Fluoro-Jade
KW - intralaminar thalamus
KW - neuronal degeneration
KW - neurotoxicity
N1 - Accession Number: 44405730; Schmued, Larry 1; Slikker, William 1; Clausing, Peter 1,2; Bowyer, John 1; Email Address: jbowyer@nctr.fda.gov; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; 2: Scantox Biological Laboratories, 4623 Lille, Skensved, Denmark; Issue Info: Mar1999, Vol. 48 Issue 1, p100; Subject Term: Fenfluramine; Subject Term: Serotonin uptake inhibitors; Subject Term: Purkinje cells; Subject Term: Neurons; Subject Term: Fever; Author-Supplied Keyword: anoretic; Author-Supplied Keyword: anterior cingulate cortex; Author-Supplied Keyword: dexfenfluramine; Author-Supplied Keyword: Fluoro-Jade; Author-Supplied Keyword: intralaminar thalamus; Author-Supplied Keyword: neuronal degeneration; Author-Supplied Keyword: neurotoxicity; Number of Pages: 7p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Temple, Robert
AU - Temple, R
T1 - Meta-analysis and epidemiologic studies in drug development and postmarketing surveillance.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/03/03/
VL - 281
IS - 9
M3 - journal article
SP - 841
EP - 844
SN - 00987484
AB - Offers commentary on the potential value of methods of discovery of adverse consequences of drug use as well as the beneficial effects of drugs through epidemiologic methods and meta-analyses. Reference to study in the same issue by Berlin and Colditz.
KW - CLINICAL drug trials
KW - META-analysis
KW - MEDICAL research
KW - CLINICAL pharmacology
N1 - Accession Number: 1591316; Temple, Robert; Temple, R 1; Source Information: 3/3/99, Vol. 281 Issue 9, p841; Subject: CLINICAL drug trials; Subject: META-analysis; Subject: MEDICAL research; Subject: CLINICAL pharmacology; Number of Pages: 4p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107185469
T1 - Xenotransplantation: the potential and the challenges.
AU - Bloom ET
AU - Moulton AD
AU - McCoy J
AU - Chapman LE
AU - Patterson AP
Y1 - 1999/04//1999 Apr
N1 - Accession Number: 107185469. Language: English. Entry Date: 19990501. Revision Date: 20150818. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8207799.
KW - Xenografts
KW - Graft Rejection -- Immunology
KW - Graft Rejection -- Prevention and Control
KW - Communicable Diseases -- Transmission
KW - Xenografts -- Adverse Effects
KW - Zoonoses -- Transmission
KW - Organ Transplantation
KW - Animals
KW - Clinical Trials
KW - Xenografts -- Ethical Issues
KW - Public Policy
KW - Public Health
KW - Resource Databases
KW - Registries, Organ
SP - 76
EP - 83
JO - Critical Care Nurse
JF - Critical Care Nurse
JA - CRIT CARE NURSE
VL - 19
IS - 2
CY - Alisa Veijo, California
PB - American Association of Critical-Care Nurses
AB - One potential approach to solving the organ donor shortage is xenotransplantation, or use of donor organs and tissues from nonhuman donors. Biological and societal difficulties raised, progress of clinical trials, ethical issues, and evolving policy are all examined.
SN - 0279-5442
AD - Chief of the Laboratory of Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Bethesda, Md
U2 - PMID: 10401305.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107208696
T1 - Ergonomic exposure assessment: an application of the PATH systematic observation method to retail workers...Postures, Activities, Tools, and Handling (PATH) measurement method
AU - Pan CS
AU - Gardner LI
AU - Landsittel DP
AU - Hendricks SA
AU - Chiou SS
AU - Punnett L
Y1 - 1999/04//1999 Apr-Jun
N1 - Accession Number: 107208696. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Postures, Activities, Tools, and Handling (PATH) Measurement Method. NLM UID: 9505217.
KW - Back Injuries -- Prevention and Control
KW - Risk Assessment -- Methods
KW - Ergonomics
KW - Occupational Diseases -- Prevention and Control
KW - Research Instruments
KW - Risk Factors
KW - Protective Devices
KW - Biomechanics
KW - Posture
KW - West Virginia
KW - Interrater Reliability
KW - Kappa Statistic
KW - Chi Square Test
KW - Fisher's Exact Test
KW - Descriptive Statistics
KW - Human
SP - 79
EP - 87
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 5
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study examined biomechanical stressor variables (physical work exposures) in relation to job title, gender, and back-belt status in 134 retail store workers. The principal concerns were to quantitatively describe physical work exposures and to determine the degrees to which these quantitative variables correlated with job title and with the use of back belts. An additional objective was to assess the inter-rater reliability of the observation method. The systematic observation method employed was based on a modification of the PATH (Postures, Activities, Tools, and Handling) measurement method. Chi-square analysis indicated that the frequencies of bent or twisted postures followed the pattern of unloaders > stockers > department managers. For weight handled per lift, lower, or carry, the pattern was unloaders > department managers > stockers. The mean lifting frequencies per hour were 35.9 for department managers, 48.8 for stockers, and 137.4 for unloaders. Back-belt-wearing percentages were higher for unloaders (63%) compared with stockers (48%) and department managers (25%). Back-belt-wearing workers had higher levels of biomechanical stressor variables, including arm position, twisting, weight handled, and number of lifts per hour. Kappa statistics ranged from 0.5 to 0.63, a level of adequate or good reliability beyond chance. The method employed in this study is applicable in studies that require only fairly crude distinctions among biomechanical stressor variables. Nevertheless, this level of distinction may be sufficient when implementing intervention studies and control strategies for many material-handling-intensive jobs.
SN - 1077-3525
AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 10330506.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107188301
T1 - The human factors implications of peritoneal dialysis: cycler overfill incident reports.
AU - Reid MH
AU - Sawyer D
Y1 - 1999/04//1999 Apr-Jun
N1 - Accession Number: 107188301. Language: English. Entry Date: 19990501. Revision Date: 20150820. Publication Type: Journal Article; case study. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Peritoneal Dialysis -- Adverse Effects
KW - Peritoneal Dialysis -- Nursing
KW - Equipment Safety
KW - Equipment Design
KW - Infant
KW - Aged
SP - 68
EP - 71
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 5
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - US Food and Drug Administration, 1350 Piccard Dr, Room 300PP, HFZ-520, Rockville, MD 20857
U2 - PMID: 10514631.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107195256
T1 - Evaluation of endoscope sheaths as viral barriers.
AU - Baker KH
AU - Chaput MP
AU - Clavet CR
AU - Varney GW
AU - To TM
AU - Lytle CD
Y1 - 1999/04//
N1 - Accession Number: 107195256. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8607378.
KW - Sterilization and Disinfection -- Methods
KW - Endoscopes
KW - Equipment Contamination -- Prevention and Control
KW - Laryngoscopy -- Equipment and Supplies
KW - Evaluation Research
KW - Human
SP - 636
EP - 639
JO - Laryngoscope
JF - Laryngoscope
JA - LARYNGOSCOPE
VL - 109
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0023-852X
AD - Center for Devices and Radiological Health, Food and Drug Administration, 9200 Corporate Boulevard, Rockville, MD 20852. E-mail: khb@cdrh.fda.gov
U2 - PMID: 10201755.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106992866
T1 - CMHS report: building coalitions between mental health and aging.
AU - Arons BS
Y1 - 1999/04//1999 Apr
N1 - Accession Number: 106992866. Language: English. Entry Date: 20010126. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9014543.
KW - Mental Health Services -- In Old Age -- United States
KW - Aging -- Psychosocial Factors -- United States
KW - United States
KW - Aged
SP - 63
EP - 63
JO - Psychiatric Times
JF - Psychiatric Times
JA - PSYCHIATR TIMES
VL - 16
IS - 4
CY - Norwalk, Connecticut
PB - UBM Medica
SN - 0893-2905
AD - Director, Center for Mental Health Services, U.S. Department of Health and Human Services Substance Abuse and Mental Health Services Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hansen, Deborah K.
AU - LaBorde, James B.
AU - Wall, Kelly S.
AU - Holson, R. Robert
AU - Young, John F.
T1 - Pharmacokinetic considerations of dexamethasone-induced developmental toxicity in rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/04//
VL - 48
IS - 2
M3 - Article
SP - 230
EP - 239
PB - Oxford University Press / USA
SN - 10966080
AB - Dexamethasone (DEX) has been shown to elicit growth stunting and cleft palate in rat fetuses. This investigation characterized DEX dosimetry as various pharmacokinetic parameters and evaluated their impact on developmental toxicity endpoints. DEX pharmacokinetics was evaluated as a single dose on either gestation day (GD) 9 or 14, as well as on GD 14 after multiple daily dosing from GD 9 to GD 14. An additional set of pregnant rats was dosed with DEX on GD 9 through GD 14,m pharmacokinetic evaluation was conducted on GD 14 through GD 16, and teratological evaluation was conducted following sacrifice on GD 20. For all pharmacokinetic evaluations, a subcutaneous (sc) injection of 0.8 mg DEX/kg body weight together with 50 μCi 3H-DEX was administered to Sprague-Dawley rats. Blood, urine, and feces were collected for 24 or 48 h. At GD 20 sacrifice, maternal tissues as well as fetal brain and liver samples were collected as part of the laparotomy. All samples were assayed using scintillation spectrometry. DEX pharmacokinetic parameters remained similar whether dosing occurred early (GD 9) or late (GD 14) in organogenesis, or dosing occurred on multiple sequential days (GD 9-14). DEX produced maternal and fetal weight loss, fetal lethality, and cleft palate. DEX α-half-life was positively correlated with the percentage of implants affected [(number of non-live + number with cleft palate)/number of implants]/litter. Neither the area under the concentration-time curve (AUC), the maximum maternal plasma concentration (Cmax), nor the terminal phase β-half-life correlated with any fetal outcome parameters. The correlation between the percentage of the litter that was affected and half-life was improved if AUC was added in a stepwise multiple regression. These data suggest that the length of time that DEX is present in the maternal plasma at a sufficiently high concentration (i.e., slower tissue distribution of DEX) appears to be important in determining the risk of an adverse outcome in the offspring. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dexamethasone
KW - Pharmacokinetics
KW - Cleft palate
KW - Fetus -- Abnormalities
KW - Pregnancy
N1 - Accession Number: 44405745; Hansen, Deborah K. 1; LaBorde, James B. 1; Wall, Kelly S. 2; Holson, R. Robert 1,3; Young, John F. 4; Affiliations: 1: Division of Genetic and Reproductive Toxicology, Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502; 2: Pathology Associates International, 3900 NCTR Drive, Jefferson, Arkansas 72079; 3: Psychology Department, New Mexico Tech, Socorro, NM 87111; 4: Division of Biometry and Risk Assessment, Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502; Issue Info: Apr1999, Vol. 48 Issue 2, p230; Thesaurus Term: Dexamethasone; Subject Term: Pharmacokinetics; Subject Term: Cleft palate; Subject Term: Fetus -- Abnormalities; Subject Term: Pregnancy; Number of Pages: 10p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2011-11023-008
AN - 2011-11023-008
AU - Asthana, Sanjay
AU - Raffaele, Kathleen C.
AU - Greig, Nigel H.
AU - Schapiro, Mark B.
AU - Blackman, Marc R.
AU - Soncrant, Timothy T.
T1 - Neuroendocrine responses to intravenous infusion of physostigmine in patients with Alzheimer disease.
JF - Alzheimer Disease and Associated Disorders
JO - Alzheimer Disease and Associated Disorders
JA - Alzheimer Dis Assoc Disord
Y1 - 1999/04//Apr-Jun, 1999
VL - 13
IS - 2
SP - 102
EP - 108
CY - US
PB - Lippincott Williams & Wilkins
SN - 0893-0341
AD - Asthana, Sanjay, GRECC, VA Puget Sound Health Care System, American Lake Division, (182 B), Tacoma, WA, US, 98493
N1 - Accession Number: 2011-11023-008. PMID: 10372954 Partial author list: First Author & Affiliation: Asthana, Sanjay; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20110919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual meeting of the American Geriatrics Society, Nov, 1993, New Orleans, LA, US. Conference Note: Preliminary results of this study were presented at the aforementioned conference. Major Descriptor: Alzheimer's Disease; Drug Therapy; Hormones; Memory; Physostigmine. Minor Descriptor: Drug Dosages; Hypothalamic Pituitary Adrenal Axis; Intravenous Injections; Neuroendocrinology. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Mini Mental State Examination. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr-Jun, 1999. Publication History: Accepted Date: Aug 17, 1998; Revised Date: Feb 19, 1998; First Submitted Date: Apr 8, 1997. Copyright Statement: Lippincott Williams & Wilkins, Inc. 1999.
AB - We have reported that physostigmine, a reversible cholinesterase inhibitor, enhances verbal memory in patients with Alzheimer disease (AD). To elucidate the mechanism of cognition enhancement, plasma hormones were measured during high-dose acute and low-dose chronic steady-state intravenous infusions of physostigmine in nine subjects with AD. High-dose hormone responses were measured during and for 24 h after the infusion of physostigmine 1-1.5 mg over 45-60 min. Chronic responses were measured during continuous intravenous infusions of physostigmine at doses (0.5-25 mg/day) that escalated over 2 weeks, and then during 1 week infusion of the dose that optimized cognition (2-12 mg/day) or placebo administered in a randomized, double-blind, crossover design. A replicable improvement in verbal memory was found in five subjects. High-dose physostigmine infusion that produced noxious side effects resulted in significant elevation above baseline in plasma levels of adrenocorticotrophic hormone (ACTH) (p = 0.0001), Cortisol (p = 0.0001), and β-endorphin (p = 0.0001). Chronic physostigmine administration, in the absence of adverse effects, produced no significant elevation in ACTH (p = 0.08), Cortisol (p = 0.70), or β-endorphin (p = 0.82). These results indicate that high-dose physostigmine activates the hypothalamic-pituitary-adrenal (HPA) axis, likely representing a 'stress response.' In contrast, cognition-enhancing doses do not produce a peripheral corticosteroid response. Thus, physostigmine-induced memory improvement is independent of the activation of the HPA axis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug therapy
KW - memory enhancement
KW - physostigmine
KW - cholinesterase inhibitors
KW - Alzheimer's disease
KW - intravenous infusion
KW - drug dosages
KW - neuroendocrine responses
KW - hormones
KW - hypothalamic pituitary adrenal axis
KW - 1999
KW - Alzheimer's Disease
KW - Drug Therapy
KW - Hormones
KW - Memory
KW - Physostigmine
KW - Drug Dosages
KW - Hypothalamic Pituitary Adrenal Axis
KW - Intravenous Injections
KW - Neuroendocrinology
KW - 1999
DO - 10.1097/00002093-199904000-00008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-11023-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 1999-10953-007
AN - 1999-10953-007
AU - Bad Heart Bull, Loretta
AU - Kvigne, Valborg L.
AU - Leonardson, Gary R.
AU - Lacina, Loralei
AU - Welty, Thomas K.
T1 - Validation of a self-administered questionnaire to screen for prenatal alcohol use in northern plains Indian women.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 1999/04//
VL - 16
IS - 3
SP - 240
EP - 243
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
N1 - Accession Number: 1999-10953-007. Partial author list: First Author & Affiliation: Bad Heart Bull, Loretta; Aberdeen Area Indian Health Service, PHS Indian Hosp, Rapid City, SD, US. Release Date: 19990501. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Pregnancy; Prenatal Exposure; Screening Tests; Test Validity. Minor Descriptor: American Indians; Drug Abuse. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. Page Count: 4. Issue Publication Date: Apr, 1999.
AB - Validated a self-administered questionnaire (SAQ) designed to identify women who had consumed alcohol or who may be at risk of drinking during pregnancy as well as determining the quantity and frequency of alcohol and other substance use just before and during pregnancy. Ss were 208 prenatal patients (aged 15–44 yrs). Of the 208 patients, 85% were American Indian and 15% were Caucasian or African American carrying an American Indian baby. The validation included 3 components: a review of the SAQ responses by a public health nurse, a structured patient interview with the research nurse and medical record abstraction postpartum. Results show that compared with the extensive interview and medical record data, the SAQ is sensitive (76%) and specific (92.8%) in detecting pregnant women who had consumed alcohol during pregnancy and is therefore a useful screening tool for alcohol use in this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - validation of self-administered screening test
KW - detection of alcohol or other substance abuse before or during pregnancy
KW - 1999
KW - Alcohol Drinking Patterns
KW - Pregnancy
KW - Prenatal Exposure
KW - Screening Tests
KW - Test Validity
KW - American Indians
KW - Drug Abuse
KW - 1999
DO - 10.1016/S0749-3797(98)00158-5
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107212810
T1 - Unusual distributions of body fat in AIDS patients: a review of adverse events reported to the Food and Drug Administration.
AU - Mann M
AU - Piazza-Hepp T
AU - Koller E
AU - Struble K
AU - Murray J
Y1 - 1999/05//
N1 - Accession Number: 107212810. Language: English. Entry Date: 19990901. Revision Date: 20150818. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - Adipose Tissue Distribution
KW - AIDS Patients
KW - Antiviral Agents -- Adverse Effects
KW - Protease Inhibitors -- Adverse Effects
KW - United States Food and Drug Administration
KW - Databases
KW - Voluntary Reporting
KW - Drug Evaluation
KW - Adult
KW - Middle Age
KW - Male
KW - Female
SP - 287
EP - 295
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 13
IS - 5
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 10356808.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107212810&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107198100
T1 - MedWatch: a valuable resource in medical reporting.
AU - Baxter SS
Y1 - 1999/05//1999 May-Jun
N1 - Accession Number: 107198100. Language: English. Entry Date: 19990701. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9516730.
KW - Product Surveillance
KW - Equipment Safety
KW - Voluntary Reporting
KW - United States Food and Drug Administration
SP - 51
EP - 53
JO - AIRMED
JF - AIRMED
JA - AIRMED
VL - 5
IS - 3
CY - New York, New York
PB - Elsevier Science
AB - The FDA medical products reporting program has much to offer air medical professionals -- and vice versa.
SN - 1079-6134
AD - Food and Drug Administration, Nashville, Tenn
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roe, Brian
AU - Whittington, Leslie A.
AU - Fein, Sara Beck
AU - Teisl, Mario F.
T1 - IS THERE COMPETITION BETWEEN BREAST-FEEDING AND MATERNAL EMPLOYMENT?
JO - Demography
JF - Demography
Y1 - 1999/05//
VL - 36
IS - 2
M3 - Article
SP - 157
EP - 171
SN - 00703370
AB - This article examines the relationship between maternal employment and breastfeeding responsibilities of mothers using the 1993-1994 data from the U.S. Food and Drug Administration's Infant Feeding Practices Study. The perceived competition between work and family is a topic of considerable current policy interest. One area of incompatibility for women is the balance between market work and breast-feeding. Researchers estimate a set of simultaneous models of maternal employment and infant-feeding decisions suggested by the competing demands of the two activities. The duration of maternal work leave is positively related to the duration of breast-feeding. The intensity of a woman's market work is negatively related to the intensity of her breast-feeding activity. The opportunity cost of breast-feeding reflects it's impact on the length of leave from work and on the intensity of work upon return to the job. They use data from the prenatal intake survey and some or all of the postpartum surveys to determine the intensity of breast-feeding and work-leave behaviors at specific infant ages.
KW - WORKING mothers
KW - DEMOGRAPHIC surveys
KW - BREASTFEEDING (Humans)
KW - MOTHER & infant
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 2427520; Roe, Brian 1; Whittington, Leslie A. 2; Fein, Sara Beck 3; Email Address: sfein@bangatc.fda.gov; Teisl, Mario F. 4; Affiliations: 1: Ohio State University, Department of Agricultural Economics.; 2: Georgetown Public Policy Institute, Georgetown University.; 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-727, 200 C Street, SW, Washington, DC 20204.; 4: Department of Resource Economics and Policy, University of Maine.; Issue Info: May99, Vol. 36 Issue 2, p157; Thesaurus Term: WORKING mothers; Thesaurus Term: DEMOGRAPHIC surveys; Subject Term: BREASTFEEDING (Humans); Subject Term: MOTHER & infant; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 15p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107212494
T1 - One-year audiologic monitoring of individuals exposed to the 1995 Oklahoma City bombing.
AU - Van Campen LE
AU - Dennis JM
AU - Hanlin RCR
AU - King SB
AU - Velderman AM
Y1 - 1999/05//
N1 - Accession Number: 107212494. Language: English. Entry Date: 19990901. Revision Date: 20150819. Publication Type: Journal Article; questionnaire/scale; research; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Section of Audiology, Department of Otorhinolaryngology, University of Oklahoma School of Medicine; The Hough Ear Institute; and The Oklahoma City Clinic. NLM UID: 9114646.
KW - Disasters -- Oklahoma
KW - Blast Injuries -- Diagnosis
KW - Hearing Loss, Noise-Induced -- Diagnosis
KW - Funding Source
KW - Oklahoma
KW - Audiometry
KW - Questionnaires
KW - Prospective Studies
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Diagnosis, Ear
KW - Case Control Studies
KW - Descriptive Statistics
KW - Inferential Statistics
KW - Analysis of Variance
KW - Fisher's Exact Test
KW - Female
KW - Tympanic Membrane -- Injuries
KW - Tinnitus
KW - Human
SP - 231
EP - 247
JO - Journal of the American Academy of Audiology
JF - Journal of the American Academy of Audiology
JA - J AM ACAD AUDIOL
VL - 10
IS - 5
CY - Reston, Virginia
PB - American Academy of Audiology
SN - 1050-0545
AD - Centers for Disease Control and Prevention, National Institute of Occupational Safety and Health, Bioacoustics and Occupational Vibration Section, Cincinnati, OH
U2 - PMID: 10331616.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107193127
T1 - Device safety. Labor and delivery beds.
AU - Swayze SC
Y1 - 1999/05//
N1 - Accession Number: 107193127. Language: English. Entry Date: 19990601. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Beds and Mattresses
KW - Accidental Falls -- Prevention and Control -- In Infancy and Childhood
KW - Equipment Safety
KW - Obstetric Nursing
KW - Infant, Newborn
KW - Inpatients
SP - 74
EP - 74
JO - Nursing
JF - Nursing
JA - NURSING
VL - 29
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Keeping newborns safe from falls.
SN - 0360-4039
AD - Center for Devices and Radiologic Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 10358629.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107147339
T1 - HRSA's Models That Work Program: implications for improving access to primary health care.
AU - Crump RL
AU - Gaston MH
AU - Fergerson G
Y1 - 1999/05//May/Jun99
N1 - Accession Number: 107147339. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Health Services Accessibility -- Administration
KW - Primary Health Care -- Administration
KW - Interinstitutional Relations
KW - Government Agencies
KW - Community Programs
KW - Medically Underserved
KW - Health Care Delivery
KW - Program Evaluation
KW - Organizations, Nonprofit
KW - Community-Institutional Relations
KW - Community Health Services -- Administration
SP - 218
EP - 224
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 114
IS - 3
PB - Sage Publications Inc.
AB - The main objective of the Models That Work Campaign (MTW) is improving access to health care for vulnerable and underserved populations. A collaboration between the Bureau of Primary Health Care (BPHC) at the Health Resources and Services Administration (HRSA) and 39 cosponsors--among them national associations, state and federal agencies, community-based organizations, foundations, and businesses--this initiative gives recognition and visibility to innovative and effective service delivery models. Models are selected based on a set of criteria that includes delivery of high quality primary care services, community participation, integration of health and social services, quantifiable outcomes, and replicability. Winners of the competition are showcased nationally and hired to provide training to other communities, to document and publish their strategies, and to provide onsite technical assistance on request.
SN - 0033-3549
AD - Bureau of Primary Health Care, HRSA, 4350 East West Highway, 9th Fl., Bethesda, MD 20814. E-mail address: rcrump@hrsa.gov
U2 - PMID: 10476990.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goering, Peter L.
AU - Aposhian, H. Vasken
AU - Mass, Marc J.
AU - Cebrián, Mariano
AU - Beck, Barbara D.
AU - Waalkes, Michael P.
T1 - Forum. The enigma of arsenic carcinogenesis: role of metabolism.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/05//
VL - 49
IS - 1
M3 - Article
SP - 5
EP - 14
PB - Oxford University Press / USA
SN - 10966080
AB - Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic is associated with tumors of the lung, skin, bladder, and liver. While it is known to be a human carcinogen, carcinogenesis in laboratory animals by this metalloid has never been convincingly demonstrated. Therefore, no animal models exist for studying molecular mechanisms of arsenic carcinogenesis. The apparent human sensitivity, combined with our incomplete understanding about mechanisms of carcinogenic action, create important public health concerns and challenges in risk assessment, which could be met by understanding the role of metabolism in arsenic toxicity and carcinogenesis. This symposium summary covers three critical major areas involving arsenic metabolism: its biodiversity, the role of arsenic metabolism in molecular mechanisms of carcinogenesis, and the impact of arsenic metabolism on human risk assessment. In mammals, arsenic is metabolized to mono- and dimethylated species by methyltransferase enzymes in reactions that require S-adenosyl-methionine (SAM) as the methyl donating cofactor. A remarkable species diversity in arsenic methyltransferase activity may account for the wide variability in sensitivity of humans and animals to arsenic toxicity. Arsenic interferes with DNA methyltransferases, resulting in inactivation of tumor suppressor genes through DNA hypermethylation. Other studies suggest that arsenic-induced malignant transformation is linked to DNA hypomethylation subsequent to depletion of SAM, which results in aberrant gene activation, including oncogenes. Urinary profiles of arsenic metabolites may be a valuable tool for assessing human susceptibility to arsenic carcinogenesis. While controversial, the idea that unique arsenic metabolic properties may explain the apparent non-linear threshold response for arsenic carcinogenesis in humans. In order to address these outstanding issues, further efforts are required to identify an appropriate animal model to elucidate carcinogenic mechanisms of action, and to define dose-response relationships. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Arsenic
KW - Carcinogenicity
KW - Carcinogens
KW - Mammals
KW - Methyltransferases
N1 - Accession Number: 44405750; Goering, Peter L. 1; Email Address: plg@cdrh.fda.gov; Aposhian, H. Vasken 2; Mass, Marc J. 3; Cebrián, Mariano 4; Beck, Barbara D. 5; Waalkes, Michael P. 6; Affiliations: 1: Division of Life Sciences, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland; 2: Department of Molecular and Cellular Biology, and Center for Toxicology, The University of Arizona, Tucson, Arizona; 3: Biochemistry and Pathobiology Branch, Environmental Carcinogenesis Division, National Health and Environmental Effects Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina; 4: Sección de Toxicología Ambiental, CINVESTAV, Mexico, DF; 5: Gradient Corporation, Cambridge, Massachusetts; 6: Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Issue Info: May1999, Vol. 49 Issue 1, p5; Thesaurus Term: Arsenic; Thesaurus Term: Carcinogenicity; Thesaurus Term: Carcinogens; Thesaurus Term: Mammals; Subject Term: Methyltransferases; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 10p; Illustrations: 3 Diagrams, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107226161
T1 - Testing optimum viewing conditions for mammographic image displays...Proceedings of the 16th Symposium for Computer Applications in Radiology. 'PACS: Performance Improvement in Radiology.' Houston, TX, May 6-9, 1999
AU - Waynant RW
AU - Chakrabarti K
AU - Kaczmarek RA
AU - Dagenais I
Y1 - 1999/05/02/May1999 Supplement
N1 - Accession Number: 107226161. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: May1999 Supplement. Journal Subset: Allied Health; Biomedical; Computer/Information Science; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9100529.
KW - Data Display
KW - Lighting
KW - Mammography
KW - Radiography -- Equipment and Supplies
SP - 209
EP - 210
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
JA - J DIGIT IMAGING
VL - 12
CY - ,
PB - Springer Science & Business Media B.V.
AB - The viewbox luminance and viewing room light level are important parameters in a medical film display, but these parameters have not had much attention. Spatial variations and too much room illumination can mask real signal or create the false perception of a signal. This presentation looks at how scotopic light sources and dark-adapted radiologists may identify more real diseases. Copyright (c) 1999 by W.B. Saunders Company
SN - 0897-1889
AD - Food and Drug Administration, Center for Devices and Radiological Health, HFZ-134, 12725 Twinbrook Parkway, Rockville, MD 20857
U2 - PMID: 10342217.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107222950
T1 - Working together in adult community mental health services: exploring inter-professional role relations.
AU - Peck E
AU - Norman IJ
Y1 - 1999/06//
N1 - Accession Number: 107222950. Language: English. Entry Date: 19991101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9212352.
KW - Community Mental Health Services
KW - Interprofessional Relations
KW - Mental Health Personnel
KW - Professional Role
KW - Attitude of Health Personnel
KW - Collaboration
KW - Multidisciplinary Care Team -- Utilization
KW - Psychiatry
KW - Psychiatric Nursing
KW - Psychology
KW - Social Work
KW - Nursing Role
KW - Occupational Therapy
KW - Team Building
SP - 231
EP - 242
JO - Journal of Mental Health
JF - Journal of Mental Health
JA - J MENT HEALTH
VL - 8
IS - 3
CY - Oxfordshire,
PB - Routledge
AB - This is the second of two papers in this issue of JMH that draws upon an initiative by the Centre for Mental Health Services Development (CMHSD) to examine problems of inter-professional working in adult community mental health services. These problems were examined within a series of facilitated group meetings that focused on the community mental health team (CMHT), so establishing an inter-disciplinary dialogue between mental health professionals. This paper reports professionals' perceptions of their own and other mental health disciplines which help to explain why professionals working within multi-professional teams often experience problems in establishing and sustaining inter-professional collaboration. These problems were related mainly to differences in culture between professional groups and to the different values held by group members. These differences originate in professional training and are maintained subsequently by socialisation. The procedure through which inter-professional perceptions were explored emerged as a potentially valuable approach to identifying inter-professional conflict and promoting understanding of professional roles.
SN - 0963-8237
AD - Center for Mental Health Services Development, King's College London, Friars House, 157-68 Blackfriars Road, London SE1 8EZ, UK
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107217182
T1 - Commentary. Federal role in nutrition education, research, and food assistance for women and their families.
AU - Mark S
AU - Krause C
Y1 - 1999/06//
N1 - Accession Number: 107217182. Language: English. Entry Date: 19991001. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Women's Health
KW - Government Programs
KW - Nutrition Education
KW - Female
KW - United States
KW - Nutrition Policy -- United States
KW - Life Style
KW - Diet
KW - Food Services
KW - Information Resources
SP - 671
EP - 672
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 99
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Office on Women's Health, US Public Health Service, US Department of Health and Human Services, 200 Independence Ave SW, Room 728F, Washington, DC 20201
U2 - PMID: 10361527.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - West, R. Webster
AU - Kodell, Ralph L.
T1 - A Comparison of Methods of Benchmark-Dose Estimation for Continuous Response Data.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1999/06//
VL - 19
IS - 3
M3 - Article
SP - 453
EP - 459
SN - 02724332
AB - Methods of quantitative risk assessment for toxic responses that aremeasured on a continuous scale are not well established. Although risk-assessment procedures that attempt to utilize the quantitative information in such data have been proposed, there is no general agreement that these procedures are appreciably more efficient than common quantal dose-response procedures that operate on dichotomized continuous data. This paper points out an equivalence between the dose-response models of the nonquantal approach of Kodell and West(1) and a quantal probit procedure, and provides results from a Monte Carlo simulation study to compare coverage probabilities of statisticallower confidence limits on dose corresponding to specified additional risk based on applying the two procedures to continuous data from adose-response experiment. The nonquantal approach is shown to be superior, in terms of both statistical validity and statistical efficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Methodology
KW - Estimation theory
KW - Monte Carlo method
KW - Probability theory
KW - Risk management in business
KW - Efficiency
KW - non quantal
KW - probit
KW - Procedural difference
KW - quantal.
KW - Quantitative risk assessment
N1 - Accession Number: 8115006; West, R. Webster 1; Kodell, Ralph L. 2; Affiliations: 1: Department of Statistics, University of South Carolina, Columbia, South Carolina 29208; 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jun99, Vol. 19 Issue 3, p453; Thesaurus Term: Risk assessment; Subject Term: Methodology; Subject Term: Estimation theory; Subject Term: Monte Carlo method; Subject Term: Probability theory; Subject Term: Risk management in business; Author-Supplied Keyword: Efficiency; Author-Supplied Keyword: non quantal; Author-Supplied Keyword: probit; Author-Supplied Keyword: Procedural difference; Author-Supplied Keyword: quantal.; Author-Supplied Keyword: Quantitative risk assessment; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - DeGeorge, Joseph J.
AU - Meyers, Laraine L.
AU - Takahashi, Michihito
AU - Contrera, Joseph F.
T1 - Forum. The duration of non-rodent toxicity studies for pharmaceuticals.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/06//
VL - 49
IS - 2
M3 - Proceeding
SP - 143
EP - 155
PB - Oxford University Press / USA
SN - 10966080
AB - At the present time, there are no uniform standards for the duration of non-rodent chronic toxicity studies. The European Union (EU) requires a 6-month non-rodent study. In Japan, a 6-month study is sufficient for most, but not all, compounds. The U.S. Food and Drug Administration (FDA) maintains its standard duration of 12 months for non-rodents, with 6-month studies accepted for some clinical indications on a case-by-case basis. To achieve harmonization on the duration of non-rodent toxicity studies, each member regulatory region (EU, U.S., and Japan) of the International Conference on Harmonization (ICH) collected non-rodent studies with significant new toxicological findings that had occurred after 6 months. An ICH expert working group was organized that included representatives from the regulatory authorities of each ICH region, to jointly review all available case studies for the purpose of arriving at a consensus on the best duration time for non-rodent toxicity studies. Eighteen case studies were identified and evaluated (16 original cases plus 2 additional FDA cases); most of the toxicities identified fell into the following categories: (1) toxicities identified at 6 months; (2) toxicities observed at 12 months, which were absent or considered isolated and not noteworthy findings at 6 months; (3) drug-related deaths or morbidity that occurred between 6 and 12 months, with a pattern of toxicity that permitted the interpolation of findings to an intermediate interval between 6 and 12 months; and (4) to a shift in the dose response for toxicity with increasing duration of drug exposure. Of the 18 cases evaluated, 11 supported a study-duration of 9-12 months, 4 supported a duration of 12 months, and the 3 remaining cases indicated that a 6-month study would be adequate. The working group concluded that there was sufficient evidence to support a harmonized 9-month duration for non-rodent toxicity studies, which would be applicable for most categories of pharmaceuticals. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chronic toxicity testing
KW - Animal experimentation
KW - Conferences & conventions
KW - Clinical drug trials
KW - Japan
KW - United States
KW - harmonization of international standards
KW - harmonization of international standards.
KW - non-rodent toxicity studies
KW - European Union
KW - United States. Food & Drug Administration
N1 - Accession Number: 44405765; DeGeorge, Joseph J. 1; Meyers, Laraine L. 1; Takahashi, Michihito 2; Contrera, Joseph F. 3; Email Address: contrerajf@cder.fda.gov; Affiliations: 1: FDA Center for Drug Evaluation and Research, Office of Review Management, Rockville, Maryland; 2: National Institute of Health Sciences, Tokyo, Japan; 3: FDA Center for Drug Evaluation and Research, Office of Testing and Research, Rockville, Maryland; Issue Info: Jun1999, Vol. 49 Issue 2, p143; Thesaurus Term: Chronic toxicity testing; Thesaurus Term: Animal experimentation; Subject Term: Conferences & conventions; Subject Term: Clinical drug trials; Subject: Japan; Subject: United States; Author-Supplied Keyword: harmonization of international standards; Author-Supplied Keyword: harmonization of international standards.; Author-Supplied Keyword: non-rodent toxicity studies ; Company/Entity: European Union ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Illustrations: 5 Charts; Document Type: Proceeding
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Kodell, Ralph L.
T1 - Dose-response trend tests for tumorigenesis, adjusted for body weight.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/06//
VL - 49
IS - 2
M3 - Article
SP - 318
EP - 323
PB - Oxford University Press / USA
SN - 10966080
AB - Several studies have demonstrated a relationship between rodent body weight and tumor incidence for some tissue/organ sites. It is not uncommon for a chemical tested for carcinogenicity to also affect body weight. In such cases, comparisons of tumor incidence may be biased by body-weight differences across dose groups. A simple procedure was investigated for reducing this bias. This procedure divides the animals into a few groups based on body weight. Body weight at 12 months was used, before the appearance of a tumor was likely to affect body weight. Statistics for dose-response trend tests are calculated within body weight strata and pooled to obtain an overall dose-response trend test. This procedure is analogous to that currently used, of stratifying animals, based on their age at the time of removal from a study. Age stratification is used to account for differences in animal age across dose groups, which can affect comparisons of tumor incidence. Several examples were investigated where the high-dose group had reduced body weights and associated reductions in tumor incidence. When the data were analyzed by body-weight strata, some positive dose-response trend in tumor incidence was a real effect, in addition to a body weight reduction. These examples indicate that it is important to consider the effects of body weight changes as low as 10%, and perhaps below, that were caused by chemicals in 2-year bioassays for carcinogenesis. The simple procedure of analyzing tumor incidence within body-weight strata can reduce the bias introduced by weight differences across dose groups. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Carcinogenicity
KW - Toxicology -- Dose-response relationship
KW - Body weight
KW - Tumors
KW - body weight
KW - dose-response
KW - doxylamine succinate
KW - doxylamine succinate.
KW - o-nitroanisole
KW - p-nitrobenzoic acid
KW - trend test
KW - tumorigenesis
N1 - Accession Number: 44405784; Gaylor, David W. 1; Email Address: dgaylor@nctr.fda.gov; Kodell, Ralph L. 1; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Jun1999, Vol. 49 Issue 2, p318; Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogenicity; Thesaurus Term: Toxicology -- Dose-response relationship; Subject Term: Body weight; Subject Term: Tumors; Author-Supplied Keyword: body weight; Author-Supplied Keyword: dose-response; Author-Supplied Keyword: doxylamine succinate; Author-Supplied Keyword: doxylamine succinate.; Author-Supplied Keyword: o-nitroanisole; Author-Supplied Keyword: p-nitrobenzoic acid; Author-Supplied Keyword: trend test; Author-Supplied Keyword: tumorigenesis; Number of Pages: 6p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107212186
T1 - Surveillance of work-related asthma in selected U.S. states using surveillance guidelines for state health departments -- California, Massachusetts, Michigan, and New Jersey, 1993-1995 [corrected] [published erratum appears in MMWR MORB MORTAL WKLY REP 1999 Sep 24; 48(37): 833].
AU - Jajosky RAR
AU - Harrison R
AU - Reinisch F
AU - Flattery J
AU - Chan J
AU - Tumpowsky C
AU - Davis L
AU - Reilly MJ
AU - Rosenman KD
AU - Kalinowski D
AU - Stanbury M
AU - Schill DP
AU - Wood J
Y1 - 1999/06/26/06/25/1999 Supplement SS-3
N1 - Accession Number: 107212186. Corporate Author: US Department of Health and Human Services. Centers for Disease Control and Prevention. Language: English. Entry Date: 19990901. Revision Date: 20151019. Publication Type: Journal Article; algorithm; statistics; tables/charts. Supplement Title: 06/25/1999 Supplement SS-3. Journal Subset: Biomedical; Public Health; USA. NLM UID: 7802429.
KW - Occupational Diseases -- Epidemiology
KW - Asthma -- Epidemiology
KW - Asthma -- Etiology
KW - Disease Surveillance
KW - California
KW - Massachusetts
KW - Michigan
KW - New Jersey
KW - Public Health
SP - 1
EP - 20
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
JA - MMWR MORB MORTAL WKLY REP
VL - 48
IS - 24
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - Problem/Condition: Cases of work-related asthma (WRA) are sentinel health events that indicate the need for preventive intervention. WRA includes new-onset asthma caused by workplace exposure to sensitizers or irritants and preexisting asthma exacerbated by workplace exposures. Reporting Period: This report reviews cases of WRA identified by state health departments from January 1, 1993, through December 31, 1995, as well as follow-up investigations of cases and associated workplaces conducted through June 30, 1998. Description of the Systems: State-based surveillance and intervention programs for WRA are conducted in California, Massachusetts, Michigan, and New Jersey as part of the Sentinel Event Notification Systems for Occupational Risks (SENSOR) cooperative agreement program, initiated by CDC's National Institute for Occupational Safety and Health (NIOSH). Results: From 1993 through 1995, a total of 1,101 cases of WRA were identified by SENSOR surveillance staff members in California, Massachusetts, Michigan, and New Jersey. Of these 1,101 cases, 19.1% were classified as work-aggravated asthma, and 80.9% were classified as new-onset asthma. Objective evidence substantiating asthma work-relatedness was documented in the medical records of 3.4% of WRA cases identified in the two states (Michigan and New Jersey) where medical records are routinely reviewed for this information. Indoor air pollutants, dusts, cleaning materials, lubricants (e.g., metalworking fluids), and diisocyanates were among the most frequently reported causes of WRA. In addition, a well-recognized cause of occupational asthma - natural rubber latex - was identified in a new setting, the health-care industry. The most common industries associated with WRA cases included transportation equipment manufacturing (19.3%), health services (14.2%), and educational services (8.7%). Air sampling for agents known to induce occupational asthma was performed in Michigan for comparison with established federal time-weighted average exposure limits. Sixteen (13.4%) of 119 workplaces tested had airborne concentrations exceeding NIOSH recommended exposure limits (RELs); 11 (9.1%) of 121 workplaces had concentrations exceeding permissible exposure limits (PELs) of the Michigan Occupational Safety and Health Act (MIOSHA) program.* Interpretation: The surveillance data findings confirm well-recognized causes of asthma and have identified new putative causes (e.g., cleaning materials and metal-working fluids). Because the surveillance program depends on physicians' recognizing asthma work-relatedness and reporting diagnosed cases, the data are considered an underestimate of the magnitude of the WRA problem. The data also indicate that physicians are not commonly performing objective physiologic tests to substantiate a WRA diagnosis. Workplace findings suggest a need to evaluate existing exposure standards for specific agents known to induce occupational asthma (e.g., diisocyanates). Case-based surveillance can help improve the recognition, control, and prevention of WRA. The SENSOR model also provides a mechanism for workers and physicians to request workplace investigations aimed at primary prevention for other workers. Public Health Action: NIOSH and state health department representatives are working to establish a long-term agenda for state-based surveillance of work-related conditions and hazards. The results from the SENSOR WRA programs described in this report support inclusion of WRA as a priority condition warranting surveillance at the state level.
SN - 0149-2195
AD - National Institute for Occupational Safety and Health, CDC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107209869
T1 - Retrieving and using computerized patient visit data.
AU - Zelonis JI
Y1 - 1999/07//1999 Jul-Aug
N1 - Accession Number: 107209869. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Nursing; USA.
KW - Electronic Health Records
KW - Ambulatory Care Nursing
KW - Information Retrieval
KW - Native Americans
KW - Data Collection
SP - 8
EP - 10
JO - AAACN Viewpoint
JF - AAACN Viewpoint
JA - AAACN VIEWPOINT
VL - 21
IS - 4
CY - Pitman, New Jersey
PB - American Academy of Ambulatory Care Nursing
AD - Billings Area Indian Health Service, Billings, MT; e-mail: zelonis@imt.net
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Stayner, Leslie
T1 - Protecting Public Health in the Face of Uncertain Risks: The Example of Diesel Exhaust.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/07//
VL - 89
IS - 7
M3 - Editorial
SP - 991
EP - 993
PB - American Public Health Association
SN - 00900036
AB - The article examines the challenges being faced by U.S. regulatory agencies of performing risk assessments for occupational and environmental exposures to diesel exhaust. The severe burden posed by formal risk assessments, required for setting occupational and environmental health standards have caused delays in the development of effective standards. The problem associated with the issue prompted some environmentalists to question the utility of risk assessments for addressing current public health problems.
KW - Health risk assessment
KW - Environmental risk assessment
KW - Diesel motor exhaust gas
KW - Public health -- United States
KW - United States
N1 - Accession Number: 2009949; Stayner, Leslie 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jul99, Vol. 89 Issue 7, p991; Thesaurus Term: Health risk assessment; Thesaurus Term: Environmental risk assessment; Thesaurus Term: Diesel motor exhaust gas; Subject Term: Public health -- United States; Subject: United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - How-Ran Guo
AU - Tanaka, Shiro
AU - Halperin, William E.
AU - Cameron, Lorraine L.
T1 - Back Pain Prevalence in US Industry and Estimates of Lost Workdays.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/07//
VL - 89
IS - 7
M3 - Article
SP - 1029
EP - 1035
PB - American Public Health Association
SN - 00900036
AB - Objectives. Back pain is the most common reason for filing workers' compensation claims and often causes lost workdays. Data from the 1988 National Health Interview Survey were analyzed to identify high-risk industries and to estimate the prevalence of work-related back pain and number of workdays lost. Methods. Analyses included 30074 respondents who worked during the 12 months before the interview. A case patient was defined as a respondent who had back pain every day for a week or more during that period. Result. The prevalence of lost-workday back pain was 4.6%, and individuals with work-related cases lost 101. .8 million workdays owing to back pain. Male and female case patients lost about the same number of work-days. Industries in high-risk categories were also identified for future research and interventions, including those seldom studied. Conclusions. This study provides statistically reliable national estimates of the prevalence of back pain among workers and the enormous effect of this condition on American industry in terms of lost workdays. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Backache
KW - Working hours
KW - Absenteeism (Labor)
KW - Sick leave -- United States
KW - United States
N1 - Accession Number: 2009959; How-Ran Guo 1,2; Email Address: hrguo@mail.ncku.edu.tw; Tanaka, Shiro 1; Halperin, William E. 1; Cameron, Lorraine L. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan; Issue Info: Jul99, Vol. 89 Issue 7, p1029; Thesaurus Term: Occupational diseases; Subject Term: Backache; Subject Term: Working hours; Subject Term: Absenteeism (Labor); Subject Term: Sick leave -- United States; Subject: United States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107145761
T1 - Protecting public health in the face of uncertain risks: the example of diesel exhaust.
AU - Stayner L
Y1 - 1999/07//
N1 - Accession Number: 107145761. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Public Health
KW - Risk Assessment
KW - Occupational Exposure
KW - United States Occupational Safety and Health Administration -- Standards
KW - United States Environmental Protection Agency -- Standards
KW - Air Pollutants, Occupational -- Adverse Effects
SP - 991
EP - 993
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 89
IS - 7
CY - Washington, District of Columbia
PB - American Public Health Association
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio
U2 - PMID: 10394303.
DO - 10.2105/AJPH.89.7.991
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107145790
T1 - Back pain prevalence in US industry and estimates of lost workdays.
AU - Guo H
AU - Tanaka S
AU - Halperin WE
AU - Cameron LL
Y1 - 1999/07//
N1 - Accession Number: 107145790. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Back Pain -- Epidemiology
KW - Industry -- Economics
KW - Worker's Compensation -- Economics
KW - Sick Leave -- Economics
KW - Surveys
KW - Probability Sample
KW - Epidemiological Research
KW - Interviews
KW - Data Analysis Software
KW - Occupational Diseases -- Economics
KW - Risk Factors
KW - Industry -- Classification
KW - Economic Aspects of Illness
KW - Male
KW - Female
KW - Human
SP - 1029
EP - 1035
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 89
IS - 7
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: Back pain is the most common reason for filing workers' compensation claims and often causes lost workdays. Data from the 1988 National Health Interview Survey were analyzed to identify high-risk industries and to estimate the prevalence of work-related back pain and number of workdays lost. METHODS: Analyses included 30074 respondents who worked during the 12 months before the interview. A case patient was defined as a respondent who had back pain every day for a week or more during that period. RESULTS: The prevalence of lost-workday back pain was 4.6%, and individuals with work-related cases lost 101.8 million workdays owing to back pain. Male and female case patients lost about the same number of workdays. Industries in high-risk categories were also identified for future research and intervention, including those seldom studied. CONCLUSIONS: This study provides statistically reliable national estimates of the prevalence of back pain among workers and the enormous effect of this condition on American industry in terms of lost workdays.
SN - 0090-0036
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
U2 - PMID: 10394311.
DO - 10.2105/AJPH.89.7.1029
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Duydu, Y.
AU - Süzen, S.
AU - Erdem, N.
AU - Uysal, H.
AU - Vural, N.
T1 - Validation of Hippuric Acid as a Biomarker of Toluene Exposure.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1999/07//
VL - 63
IS - 1
M3 - Article
SP - 1
EP - 8
SN - 00074861
AB - The article presents a study that investigates the relation between hippuric acid excretion and toluene exposure in low concentrations. Hippuric Acid has one of the most studied metabolites that showed toluene exposure. However, urinary hippuric acid was determined using M. Ogata's High Performance Liquid Chromatography method. The study was performed in collaboration with the National Institute of Occupational Safety and Health, and they measured the breathing zone concentrations of toluene. Moreover, the National Institute makes a routine health inspection in plants where toluene is used.
KW - Toluene
KW - Absorption
KW - Industrial hygiene
KW - Industrial safety
KW - Plants
KW - Urine
KW - Hippuric acid
KW - High performance liquid chromatography
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 15731021; Duydu, Y. 1; Süzen, S. 1; Erdem, N. 2; Uysal, H. 2; Vural, N. 1; Affiliations: 1: University of Ankara, Faculty of Pharmacy, Department of Toxicology, 06100, Tandoğan, Ankara, Turkey; 2: The National Institute of Occupational Safety and Health, Etimesgut, Ankara, Turkey; Issue Info: Jul99, Vol. 63 Issue 1, p1; Thesaurus Term: Toluene; Thesaurus Term: Absorption; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Plants; Subject Term: Urine; Subject Term: Hippuric acid; Subject Term: High performance liquid chromatography ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 8p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107215662
T1 - From the Food and Drug Administration. Nurses play a pivotal role in adverse event problem identification.
AU - Rich S
Y1 - 1999/07//1999 Jul-Sep
N1 - Accession Number: 107215662. Language: English. Entry Date: 19991001. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Consumer Product Safety
KW - Equipment Safety
KW - Nursing Role
KW - Problem Identification
KW - Mandatory Reporting
KW - Voluntary Reporting
KW - United States Food and Drug Administration
SP - 110
EP - 112
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 5
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Food and Drug Administration, 1350 Piccard Dr, HFZ 520, Rockville, MD 20850
U2 - PMID: 10514642.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 89522596
T1 - Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin.
AU - Herman, Eugene H.
AU - Jun Zhang
AU - Lipshultz, Steven E.
AU - Rifai, Nader
AU - Chadwick, Douglas
AU - Kazuyo Takeda
AU - Zu-Xi Yu
AU - Ferrans, Victor J.
AU - Herman, E H
AU - Zhang, J
AU - Lipshultz, S E
AU - Rifai, N
AU - Chadwick, D
AU - Takeda, K
AU - Yu, Z X
AU - Ferrans, V J
Y1 - 1999/07//7/1/1999
N1 - Accession Number: 89522596. Language: English. Entry Date: 19991001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Wide Range Achievement Test (WRAT). NLM UID: 8309333.
KW - Doxorubicin
KW - Drug Monitoring -- Methods
KW - Myocardial Diseases -- Chemically Induced
KW - Antineoplastic Agents
KW - Myocardial Diseases -- Blood
KW - Troponin -- Blood
KW - Rats
KW - Chronic Disease
KW - Sensitivity and Specificity
KW - Nonparametric Statistics
KW - Myocardial Diseases -- Pathology
KW - Male
KW - Immunohistochemistry
KW - Animals
KW - Severity of Illness Indices
SP - 2237
EP - 2243
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 17
IS - 7
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: To investigate, over a wide range of cumulative doxorubicin doses, the feasibility of using serum concentrations of cardiac troponin-T (cTnT) as a biomarker for doxorubicin-induced myocardial damage.Materials and Methods: Groups of spontaneously hypertensive rats (SHR) were given 1 mg/kg doxorubicin weekly for 2 to 12 weeks. Cardiomyopathy scores were assessed according to the method of Billingham and serum levels of cTnT were quantified by a noncompetitive immunoassay. Myocardial localization of cTnT was studied by immunohistochemical staining and confocal microscopy.Results: Increases in serum levels of cTnT (0.03 to 0.05 ng/mL) and myocardial lesions (cardiomyopathy scores of 1 or 1.5) were found in one out of five and two out of five SHR given 2 and 4 mg/kg doxorubicin, respectively. All animals given 6 mg/kg or more of doxorubicin had increases in serum cTnT and myocardial lesions. The average cTnT levels and the cardiomyopathy scores correlated with the cumulative dose of doxorubicin (0.13 v 0.4 ng/mL cTnT and scores of 1.4 v 3.0 in SHR given 6 and 12 mg/kg doxorubicin, respectively). Decreased staining for cTnT was observed in cardiac tissue from SHR receiving cumulative doses that caused only minimal histologic alterations (scores of 1 to 1.5). Staining for cTnT decreased simultaneously with increases in the severity of the cardiomyopathy scores.Conclusion: cTnT is released from doxorubicin-damaged myocytes. Measurements of serum levels of this protein seem to provide a sensitive means for assessing the early cardiotoxicity of doxorubicin.
SN - 0732-183X
AD - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD
AD - Division of Pediatric Cardiology, University of Rochester Medical Center, Rochester, NY
AD - Department of Laboratory Medicine, Boston Childrens Hospital and Harvard Medical School, Boston, MA
AD - Pathology Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
AD - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD 20708, USA
U2 - PMID: 10561281.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107045099
T1 - PCR-RFLP analysis of the coagulase gene of Staphylococcus aureus: application to the differentiation of epidemic and sporadic methicillin-resistant strains.
AU - Hookey JV
AU - Edwards V
AU - Cookson BD
AU - Richardson JF
Y1 - 1999/07//1999 Jul
N1 - Accession Number: 107045099. Language: English. Entry Date: 20010817. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8007166.
KW - Polymerase Chain Reaction -- Methods
KW - Staphylococcus Aureus
KW - Methicillin Resistance
KW - Cross Infection -- Prevention and Control
KW - Microbiological Techniques
KW - Staphylococcus Aureus -- Classification
KW - In Vitro Studies
KW - Human
SP - 205
EP - 212
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
JA - J HOSP INFECT
VL - 42
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Preventing cross-infection with epidemic strains of methicillin-resistant Staphylococcus aureus (MRSA) requires effective control measures. These call for simple, rapid, discriminatory and reproducible methods for typing this pathogen. In this study 140 isolates/strains from 105 hospitals in England and Wales, representing 72 diverse phage types, were analysed by bacteriophage typing and PCR coagulase (coa) gene restriction fragment length polymorphism (RFLP). Isolates gave a coa gene PCR product that was either 660 base pairs (bp), 603 bp or 547 pb in size. The PCR products were digested with Alu I and Cfo I, and the fragments separated by gel electrophoresis. Eight coa gene RFLP patterns, numbered 1 to 8, were observed. Pattern 3 was most common (N = 25 isolates), followed by patterns 2 and 5 (18 isolates each), pattern 1 (14 isolates), pattern 4 (11 isolates), pattern 7 (10 isolates), pattern 8 (eight isolates) and pattern 6 (six isolates). Isolates of the same phage type often gave different coa gene RFLP patterns, and the patterns within the epidemic types EMRSA-03, EMRSA-15 and EMRSA-16 were heterogeneous. Thus, representatives of EMRSA-03 were subtyped to coa RFLP patterns 1 and 2, those of EMRSA-05 to coa RFLP patterns 1, 2, 7 and 8, and those for EMRSA-16 to coa RFLP patterns 2, 3, 4, 5 and 6. The range of patterns within single phage types of S. aureus could help to discriminate between isolates/strains, and in a hierarchical approach coa gene RFLP could occupy an intermediate position between phage typing and pulsed-field gel electrophoresis (PFGE). Copyright © 1999 The Hospital Infection Society
SN - 0195-6701
AD - Molecular Biology Unit, Virus Reference Laboratory, Central Public Health Service, Colindale, London NW9 5HT, UK
U2 - PMID: 10439993.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107045103
T1 - The efficacy of three common hospital liquid germicides to inactivate Cryptosporidium parvum oocysts.
AU - Wilson JA
AU - Margolin AB
Y1 - 1999/07//1999 Jul
N1 - Accession Number: 107045103. Language: English. Entry Date: 20010817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8007166.
KW - Cryptosporidium
KW - Disinfectants
KW - Sterilization and Disinfection -- Methods
KW - Phenols
KW - Povidone-Iodine
KW - Glutaraldehyde
KW - Culture Media
KW - Human
SP - 231
EP - 237
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
JA - J HOSP INFECT
VL - 42
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - We evaluated three commonly used hospital disinfectants against three concentrations of Cryptosporidium parvum oocysts (1.5 x 10(6), 1.5 x 10(5), 1.5 x 10(4)). A 10% phenol product, a 10% povidone-iodine product and a 2.5% glutaraldehyde product were tested against Cryptosporidium parvum oocysts without organic load. In-vitro excystation was used to determine viability and a cell culture assay was used to determine infectivity of germicide-treated oocysts. A 2.5% glutaraldehyde product was the most effective in halting excystation of sporozoites and infection in cell monolayers. However, this occurred only at the longest exposure time of 10 h and with the lowest concentration of oocysts (1.5 x 10(4)). The 10% phenol product and the 10% povidone-iodine product also decreased excystation, but were unable to halt infection. Although the ability of C. parvum to with-stand chemical treatment is well known, the ability of oocysts to remain viable and infectious after a 10 h treatment in glutaraldehyde is cause for concern. Endoscopic equipment that may come into contact with these organisms cannot be immersed into glutaraldehyde for this length of time due to its corrosive nature. Thus, the results of this research are cause for concern in hospital disinfection units. Copyright © 1999 The Hospital Infection Society
SN - 0195-6701
AD - United States Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St, Winchester, MA 01890
U2 - PMID: 10439996.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107211204
T1 - Radiographic trends of dental offices and dental schools.
AU - Suleiman OH
AU - Spelic DC
AU - Conway B
AU - Hart JC
AU - Boyce PR
AU - Antonsen RG JR.
Y1 - 1999/07//
N1 - Accession Number: 107211204. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: 1995-1996 Dental School Survey; 1993 Nationwide Evaluation of X-ray Trends (NEXT) Survey. NLM UID: 7503060.
KW - Radiography, Dental -- Trends
KW - Research Instruments
KW - Radiation Dosage
KW - Schools, Dental -- Trends
KW - Absorptiometry, Photon
KW - Practitioner's Office
KW - Comparative Studies
KW - Surveys
KW - Random Sample
KW - Bias (Research)
KW - Descriptive Statistics
KW - United States Food and Drug Administration
KW - United States
KW - Human
SP - 1104
EP - 1110
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 130
IS - 7
CY - Chicago, Illinois
PB - American Dental Association
AB - BACKGROUND: A survey of private practice facilities in the United States that perform dental radiography was conducted in 1993 and repeated in dental schools in 1995-1996. METHODS: Both surveys were conducted as part of the Nationwide Evaluation of X-ray Trends, or NEXT, survey program. A representative sample of dental facilities from each participating state were surveyed, and data on patient radiation exposure, radiographic technique, film-image quality, film-processing quality and darkroom fog were collected. RESULTS: The authors found that dental schools use E-speed film more frequently than do private practice facilities. The use of E-speed film and better film processing by dental schools resulted in lower patient radiation exposures without sacrificing image quality. The authors also found that dental school darkrooms had lower ambient fog levels than did those of private practice facilities. CONCLUSIONS: The distribution for the 1993 NEXT survey facilities was greater than that observed for dental schools for radiation exposure, film-processing quality and darkroom fog. Dental schools, in general, had better film quality and lower radiation exposures than did private practice facilities. PRACTICE IMPLICATIONS: Facilities need to emphasize better quality processing and the use of E-speed film to reduce patient exposure and improve image quality.
SN - 0002-8177
AD - Radiation Programs, Division of Mammography Quality and Radiation Programs, U.S. Department of Health and Human Services, Public Health Service, U.S. Food and Drug Administration, 1350 Picard Drive, HFZ-240, Rockville, MD 20850
U2 - PMID: 10422407.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107211204&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107205025
T1 - Device safety. Don't make a splash.
AU - Dillard SF
Y1 - 1999/07//
N1 - Accession Number: 107205025. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Disinfectants -- Adverse Effects
KW - Occupational Exposure -- Prevention and Control
KW - Occupational Safety
KW - Protective Devices
KW - Corneal Diseases -- Chemically Induced
SP - 74
EP - 74
JO - Nursing
JF - Nursing
JA - NURSING
VL - 29
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Avoid injuries from liquid chemical disinfectants.
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 10446583.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107205025&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107212914
T1 - Young workers.
AU - Castillo DN
AU - Davis L
AU - Wegman DH
Y1 - 1999/07//1999 Jul-Sep
N1 - Accession Number: 107212914. Language: English. Entry Date: 19990901. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Child Welfare
KW - Occupational Health
KW - Employment -- In Adolescence -- United States
KW - United States
KW - Occupational Diseases -- Epidemiology -- United States
KW - Occupational Diseases -- Prevention and Control
KW - Child
KW - Adolescence
KW - Health Promotion
KW - Health Status
KW - Accidents, Occupational -- Prevention and Control
SP - 519
EP - 536
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 14
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Until recently, today's occupational safety and health experts have paid little attention to safety and health concerns of working youth. Yet with millions of children and adolescents employed each year, young workers are indeed a special population at risk deserving special attention. Occupational safety and health professionals have critical knowledge and skills to contribute to researching special issues for young workers and promoting safe and healthful work for youth. Unique opportunities for intervention hold the potential for new and rewarding partnerships with, for example, pediatricians and adolescent health specialists, child labor regulators, child injury prevention professionals, maternal and child health professionals, educators, and community leaders. Lessons learned in targeting young workers can have important implications for reaching other special populations that have not been well addressed through conventional approaches to occupational safety and health.
SN - 0885-114X
AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS P-180, Morgantown, WV 26505
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107212914&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107082726
T1 - Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use...including commentary by Rosenberg IN
AU - Lewis CJ
AU - Crane NT
AU - Wilson DB
AU - Yetley EA
Y1 - 1999/08//
N1 - Accession Number: 107082726. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Nutritional Assessment
KW - Folic Acid
KW - Food, Fortified
KW - Biological Availability
KW - Dietary Reference Intakes
KW - Databases
KW - Community Living
KW - Food Intake
KW - United States Department of Agriculture
KW - Centers for Disease Control and Prevention (U.S.)
KW - Government Regulations
KW - Recipes
KW - Measurement Issues and Assessments
KW - Survey Research
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Diet
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Male
KW - Female
KW - Human
SP - 198
EP - 198
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 70
IS - 2
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - BACKGROUND: There is a critical need to estimate dietary folate intakes for nutrition monitoring and food safety evaluations, but available intake data are seriously limited by several factors. OBJECTIVE: Our objective was to update 2 national food consumption surveys to reflect folate intakes as a result of the recently initiated food fortification program and to correct folate intakes for the apparently higher bioavailability of synthetic folic acid (SFA; ie, folate added to foods or from dietary supplements) than of naturally occurring folate so as to express intakes as dietary folate equivalents. DESIGN: It was not possible to chemically analyze foods, so adjustments were made to food-composition data by using information about food ingredients and characteristics. Total folate intakes were estimated for several sex and age groups by using the modified data coupled with dietary supplement use. RESULTS: Within the limitations of the data, our findings suggested that 67-95% of the population met or surpassed the new estimated average requirement, depending on the sex and age group and survey. Nonetheless, some subgroups had estimated intakes below these standards. Estimated SFA intakes suggested that approximately 15-25% of children aged 1-8 y, depending on the survey, had intakes above the newly established tolerable upper intake level. We estimated that 68-87% of females of childbearing age had SFA intakes below the recommended intake of 400 microgram/d, depending on the age group and survey. CONCLUSION: There is a need to explore ways to improve folate intakes in targeted subgroups, including females of childbearing age, while not putting other population groups at risk of excessive intakes. Copyright (c) 1999 American Society for Clinical Nutrition
SN - 0002-9165
AD - Food and Drug Administration, HFS-451, 200 C St, SW, Washington, DC 20204; email clewis1@bangate.fda.gov
U2 - PMID: 10426695.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107082726&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107078817
T1 - Closing editorial. Telehomecare: is it in your future?
AU - Puskin DS
Y1 - 1999/08//1999 Aug
N1 - Accession Number: 107078817. Language: English. Entry Date: 20000101. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Nursing; USA. NLM UID: 8301759.
KW - Telemedicine -- Trends
KW - Home Health Care -- Trends
KW - Technology, Medical -- Utilization
KW - Health Care Delivery -- Trends
KW - Health Services Accessibility
SP - 64
EP - 64
JO - Caring
JF - Caring
JA - CARING
VL - 18
IS - 8
CY - Washington, District of Columbia
PB - National Association for Home Care
SN - 0738-467X
AD - Director, Office for the Advancement of Telehealth, Health Resources and Services Administration, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107078817&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104718091
T1 - Trends in hospitalizations associated with gastroenteritis among adults in the United States, 1979-1995.
AU - Mounts, A W
AU - Holman, R C
AU - Clarke, M J
AU - Bresee, J S
AU - Glass, R I
Y1 - 1999/08//08/01/1999
N1 - Accession Number: 104718091. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Diarrhea -- Epidemiology
KW - Gastroenteritis -- Epidemiology
KW - Hospitalization -- Trends
KW - Adult
KW - Demography
KW - Aged
KW - Diarrhea -- Ethnology
KW - Diarrhea -- Etiology
KW - Female
KW - Gastroenteritis -- Ethnology
KW - Gastroenteritis -- Etiology
KW - Surveys
KW - Hospitalization -- Statistics and Numerical Data
KW - Human
KW - Male
KW - Middle Age
KW - Retrospective Design
KW - Seasons
KW - United States
SP - 1
EP - 8
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 123
IS - 1
PB - Cambridge University Press
AB - Gastroenteritis (GE) is among the most common illnesses of humans but the burden of disease, its epidemiology, and the distribution of pathogens in adults have not been fully examined. This information is needed to plan prevention strategies particularly for high-risk groups. This study is a retrospective analysis of data from the National Hospital Discharge Survey for the years 1979 through 1995 which describes the disease burden and epidemiology of hospitalizations associated with GE among adults in the United States. Diarrhoea was listed as a diagnosis on an average of 452,000 hospital discharges per year representing 1.5% of all hospitalizations among adults. The annual number of GE hospitalizations has decreased by 20% from approximately 500,000 in 1979 to 400,000 in 1995. The aetiology of 78% of cases coded as GE was undetermined. Until the aetiology of disease can be better established, specific strategies for prevention cannot be developed.
SN - 0950-2688
AD - Epidemic Intelligence Service, Epidemiology, Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Dept. of Health and Human Services, Atlanta, GA 30333, USA.
U2 - PMID: 10487635.
DO - 10.1017/S0950268899002587
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104718091&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107078587
T1 - A pseudoepidemic of postoperative scleritis due to misdiagnosis.
AU - Burwen DR
AU - Margo CE
AU - McNeil MM
AU - Brown JM
AU - Tapelband G
AU - Jenkins RB
AU - Jarvis WR
Y1 - 1999/08//1999 Aug
N1 - Accession Number: 107078587. Language: English. Entry Date: 20000101. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Surgical Wound Infection -- Diagnosis
KW - Disease Outbreaks
KW - Cataract Extraction -- Adverse Effects
KW - Pseudoinfections
KW - Diagnostic Errors
KW - Epidemiological Research
KW - Disease Surveillance
KW - Data Analysis Software
KW - Fisher's Exact Test
KW - Kruskal-Wallis Test
KW - Microbial Culture and Sensitivity Tests
KW - Relative Risk
KW - P-Value
KW - Retrospective Design
KW - Sclera
KW - Risk Factors
KW - Surgical Wound -- Standards
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Inpatients
KW - Human
SP - 539
EP - 542
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 20
IS - 8
PB - Cambridge University Press
AB - OBJECTIVE: To describe a pseudoepidemic of infectious scleritis following eye surgery. METHODS: Retrospective cohort study with selected procedural and laboratory investigations. RESULTS: Twenty-one patients with postoperative scleritis were identified during a 2-month outbreak. Neither an infectious etiology nor a causative pre-, intra-, or postoperative exposure was found. The clinical findings, when carefully reviewed, were consistent with poor surgical-wound closure. CONCLUSIONS: The art of clinical diagnosis involves the subjective interpretation of clinical history, physical findings, and laboratory results. A repeated error in the interpretation of clinical findings can simulate an outbreak of disease. Clinicians may be reluctant to concede misdiagnosis.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 10466553.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107078587&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107213160
T1 - Who was John Howard?
AU - Lasure EA
Y1 - 1999/08//1999 Aug
N1 - Accession Number: 107213160. Language: English. Entry Date: 19990901. Revision Date: 20150818. Publication Type: Journal Article; biography; CEU; exam questions; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8200911.
KW - Philanthropy -- History
KW - Correctional Facilities -- History
KW - Mentally Ill Offenders
KW - Patient Advocacy -- History
KW - England
KW - Social Change -- History
KW - Education, Continuing (Credit)
KW - Howard J
SP - 43
EP - 49
JO - Journal of Psychosocial Nursing & Mental Health Services
JF - Journal of Psychosocial Nursing & Mental Health Services
JA - J PSYCHOSOC NURS MENT HEALTH SERV
VL - 37
IS - 8
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - John Howard was an 18th-century English philanthropist who made significant contributions in prison reform. Despite personal tragedy and an oppositional social climate, he became an early promoter of humane treatment for prisoners. Other reformers followed John Howard, making valuable contributions, but many challenges remain in the management of forensic hospitals and prison systems. Howard's legacy is not only the modernization of prison structures and programs, but also the work of numerous worldwide societies and associations that provide services for communities and prisoners.
SN - 0279-3695
AD - Commander, US Public Health Service, Washington, DC
U2 - PMID: 10461276.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107213160&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107078562
T1 - An explanatory model of variables influencing health promotion behaviors in smoking and nonsmoking college students.
AU - Martinelli AM
Y1 - 1999/08//
N1 - Accession Number: 107078562. Language: English. Entry Date: 20000101. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: ETS-Avoidance Scale; Self Efficacy Scale; Health-Promoting Lifestyle Profile (HPLP) (Walker et al); Multidimensional Health Locus of Control Scale (LOC) (Wallston et al). NLM UID: 8501498.
KW - Health Promotion
KW - Health Behavior
KW - Students, College -- Psychosocial Factors
KW - Smoking -- Psychosocial Factors
KW - Pender Health Promotion Model
KW - Multidimensional Health Locus of Control Scales
KW - Validation Studies
KW - Path Analysis
KW - Convenience Sample
KW - Questionnaires
KW - Self Report
KW - Descriptive Statistics
KW - Summated Rating Scaling
KW - Coefficient Alpha
KW - Construct Validity
KW - Discriminant Validity
KW - Self-Efficacy
KW - Locus of Control
KW - Health Status
KW - Sex Factors
KW - Correlation Coefficient
KW - Regression
KW - P-Value
KW - Adolescence
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 263
EP - 269
JO - Public Health Nursing
JF - Public Health Nursing
JA - PUBLIC HEALTH NURS
VL - 16
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - College students can establish healthy lifestyle practices that can have lifelong implications. Many students, however, continue to engage in risky behaviors such as active and passive smoking. The purpose of this study was to test an explanatory model of variables which can influence health promotion behaviors in smoking and nonsmoking college students. Pender's Health Promotion Model provided the framework for the study. Health promotion behaviors were found to be most effective when students: had an increased self-efficacy, avoided environmental tobacco smoke (ETS), perceived themselves as healthy, were female, and had a powerful external and internal health locus of control. College students may benefit from health promotion interventions designed to influence the avoidance of ETS and alter perceptions of self-efficacy, control of health, and health status. Such interventions may result in a decrease in both active and passive smoking.
SN - 0737-1209
AD - Division of Nursing, Parklawn Building, Room 9-36, 5600 Fishers Lane, Rockville, MD 20857. E-mail: amartinelli@hrsa.gov
U2 - PMID: 10499015.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107078562&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Temple, Robert
AU - Temple, R
T1 - Are surrogate markers adequate to assess cardiovascular disease drugs?
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/08/25/
VL - 282
IS - 8
M3 - journal article
SP - 790
EP - 795
SN - 00987484
AB - Focuses on the use of surrogate end points as a basis for reaching conclusions about the benefit of its therapeutic use in cardiovascular disease. Defining surrogate end points; Regulatory status of end points; Risk of reliance on a surrogate.
KW - CARDIOVASCULAR diseases -- Treatment
KW - CARDIOVASCULAR system
KW - BLOOD circulation
KW - HEART diseases -- Treatment
N1 - Accession Number: 2182203; Temple, Robert; Temple, R 1; Source Information: 8/25/99, Vol. 282 Issue 8, p790; Subject: CARDIOVASCULAR diseases -- Treatment; Subject: CARDIOVASCULAR system; Subject: BLOOD circulation; Subject: HEART diseases -- Treatment; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: journal article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=2182203&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107080840
T1 - American Indian and Alaska native trends in behavioral health, 1990-1996.
AU - Taylor TL
AU - Denny CH
AU - Freeman WL
Y1 - 1999/09//Sep/Oct99
N1 - Accession Number: 107080840. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9602338.
KW - Health Behavior -- Trends
KW - Native Americans
KW - Cluster Sample
KW - Chi Square Test
KW - Secondary Analysis
KW - Linear Regression
KW - Data Analysis, Statistical
KW - Data Analysis Software
KW - Educational Status
KW - Comparative Studies
KW - Whites
KW - Smoking -- Trends
KW - Weight Control -- Trends
KW - Diabetes Mellitus -- Trends
KW - Alcohol Drinking -- Trends
KW - Car Safety Devices -- Utilization
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 345
EP - 351
JO - American Journal of Health Behavior
JF - American Journal of Health Behavior
JA - AM J HEALTH BEHAV
VL - 23
IS - 5
CY - Oak Ridge, North Carolina
PB - PNG Publications
AB - Objectives: To analyze and evaluate American Indian trends in behavioral risk for the period 1990 to 1996. Methods: Data on 5 health behaviors were drawn from the 1990-1996 Behavioral Risk Factor Surveillance System (BRFSS) representing the 34 states covered by the Indian Health Service. Time trends were analyzed with the use of linear regression. Results: Diabetes increased among Indian men. The average annual percentage-point increase in diabetes awareness among Indian men was 0.4 (p<.05). Conclusions: Greater attention needs to be focused on Indian health-risk behaviors, especially diabetes awareness, as well as the surveillance of related behaviors such as overweight, physical activity, and diet. States should be encouraged and provided resources to improve BRFSS Indian samples.
SN - 1087-3244
AD - Alcoholism and Substance Abuse Program, Indian Health Service, 5300 Homestead Road NE, Albuquerque, NM 87110; e-mail: Timothy.Taylor@mail.ihs.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107080840&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107224100
T1 - Reliability and validity of the self-assessment of occupational functioning.
AU - Henry AD
AU - Baron KB
AU - Mouradian L
AU - Curtin C
Y1 - 1999/09//Sep/Oct1999
N1 - Accession Number: 107224100. Language: English. Entry Date: 19991101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Self-Perception Profile; Self-Assessment of Occupational Functioning (SAOF) (Baron and Curtin). Grant Information: Supported, in part, by a grant to Sargent College of Allied Health Professions, Boston University, from the US Department of Health and Human Services, Division of Maternal and Child Health Services. NLM UID: 7705978.
KW - Functional Assessment
KW - Instrument Validation
KW - Adaptation, Occupational -- Evaluation
KW - Self Assessment
KW - Analysis of Covariance
KW - Self Report
KW - Checklists
KW - Kappa Statistic
KW - Intraclass Correlation Coefficient
KW - Test-Retest Reliability
KW - Coefficient Alpha
KW - Internal Consistency
KW - Discriminant Analysis
KW - T-Tests
KW - P-Value
KW - Spearman's Rank Correlation Coefficient
KW - Students, College
KW - Mental Disorders
KW - Prospective Studies
KW - Funding Source
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 482
EP - 488
JO - American Journal of Occupational Therapy
JF - American Journal of Occupational Therapy
JA - AM J OCCUP THER
VL - 53
IS - 5
CY - Bethesda, Maryland
PB - American Occupational Therapy Association
AB - OBJECTIVE: Two studies examined the reliability and validity of the Self-Assessment of Occupational Functioning (SAOF), a 23-item self-assessment of perceptions of strengths, and weaknesses relative to occupational functioning, grounded in the Model of Human Occupation. METHOD: The first study examined the test-retest reliability of the SAOF, and involved 37 college students without disabilities who completed the SAOF twice. The second study, which involved 39 young persons hospitalized with psychiatric disorders, examined internal consistency reliability of the SAOF, and examined correlations between SAOF scores and composite scores on the Self-Perception Profile, a widely used measure of perceived competence. In addition, data from both studies were combined to examine the ability of the SAOF to discriminate between the college students without disabilities and the young persons with psychiatric disorders. RESULTS: Kappa and intraclass correlation coefficients (ICCs) were used to examine test-retest reliability and Cronbach's alpha was used to examine internal consistency. Acceptable levels of test-retest (ICCs) and internal consistency (Cronbach's alpha) reliability were found for the subscale and total scores of the SAOF. However, test-retest reliability (kappa) was lower than desirable for many of the individual SAOF items. The young persons with psychiatric disorders had lower item, subscale, and total scores on the SAOF than did the college students without disabilities. In addition, a discriminant analysis predicting group membership (college students without disability vs. young persons with psychiatric disorder) correctly classified 76.6% of the participants based on the four subscale scores of the SAOF. CONCLUSION: The SAOF has the potential to be a reliable and valid clinical assessment; however, additional research is needed.
SN - 0272-9490
AD - Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655
U2 - PMID: 10500856.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107224100&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schenck, F. J.
AU - Howard-King, V.
T1 - Rapid Solid Phase Extraction Cleanup for Pesticide Residues in Fresh Fruits and Vegetables.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1999/09//
VL - 63
IS - 3
M3 - Article
SP - 277
EP - 281
SN - 00074861
AB - The article presents a study that demonstrated a rapid solid phase extraction (SPE) cleanup for Luke extracts through tandem graphitized carbon black and anion exchange SPE columns. Pesticide stock standard solutions and mixed organochlorine pesticide and organophosphorus pesticide were prepared in acetone and mixing stock standard solutions, respectively. Gas chromatography (GC) performed with a HP-5890 Series II were injected with Luke extracts that had been subjected to SPE cleanup and standards in acetone. Data collected showed that SPE method will create an excellent rapid cleanup for Luke extracts, prolonging the life of capillary GC columns while reducing the effect of sample matrix enhancement.
KW - Solid phase extraction
KW - Pesticide residues in food
KW - Gas chromatography
KW - Acetone
KW - Pesticides -- Environmental aspects
KW - Organochlorine compounds
KW - Organophosphorus compounds
KW - Extracts
KW - Anions
N1 - Accession Number: 15731066; Schenck, F. J. 1; Howard-King, V. 1; Affiliations: 1: Baltimore District Laboratory, United States Food and Drug Administration, 900 Madison Avenue, Baltimore, MD 21201, USA; Issue Info: Sep99, Vol. 63 Issue 3, p277; Thesaurus Term: Solid phase extraction; Thesaurus Term: Pesticide residues in food; Thesaurus Term: Gas chromatography; Thesaurus Term: Acetone; Thesaurus Term: Pesticides -- Environmental aspects; Subject Term: Organochlorine compounds; Subject Term: Organophosphorus compounds; Subject Term: Extracts; Subject Term: Anions; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schenck, F. J.
AU - Howard-King, V.
T1 - Rapid Solid Phase Extraction Cleanup for Pesticide Residues in Fresh Fruits and Vegetables.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 1999/09//
VL - 63
IS - 3
M3 - Article
SP - 277
EP - 281
SN - 00074861
AB - The article presents a study that demonstrated a rapid solid phase extraction (SPE) cleanup for Luke extracts through tandem graphitized carbon black and anion exchange SPE columns. Pesticide stock standard solutions and mixed organochlorine pesticide and organophosphorus pesticide were prepared in acetone and mixing stock standard solutions, respectively. Gas chromatography (GC) performed with a HP-5890 Series II were injected with Luke extracts that had been subjected to SPE cleanup and standards in acetone. Data collected showed that SPE method will create an excellent rapid cleanup for Luke extracts, prolonging the life of capillary GC columns while reducing the effect of sample matrix enhancement.
KW - Organochlorine compounds
KW - Solid phase extraction
KW - Pesticide residues in food
KW - Organophosphorus compounds
KW - Gas chromatography
KW - Acetone
KW - Pesticides -- Environmental aspects
KW - Extracts
KW - Anions
N1 - Accession Number: 15731066; Schenck, F. J. 1; Howard-King, V. 1; Affiliations: 1 : Baltimore District Laboratory, United States Food and Drug Administration, 900 Madison Avenue, Baltimore, MD 21201, USA; Source Info: Sep99, Vol. 63 Issue 3, p277; Thesaurus Term: Organochlorine compounds; Thesaurus Term: Solid phase extraction; Thesaurus Term: Pesticide residues in food; Thesaurus Term: Organophosphorus compounds; Thesaurus Term: Gas chromatography; Thesaurus Term: Acetone; Thesaurus Term: Pesticides -- Environmental aspects; Subject Term: Extracts; Subject Term: Anions; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
ID - 107228999
T1 - Keynote address: 47th annual convention.
AU - Mazzella RB
Y1 - 1999/09//1999 Sep-Oct
N1 - Accession Number: 107228999. Language: English. Entry Date: 19991201. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 0163356.
KW - Congresses and Conferences
KW - National Student Nurses Association
SP - 75
EP - 77
JO - Imprint (00193062)
JF - Imprint (00193062)
JA - IMPRINT
VL - 46
IS - 4
CY - Brooklyn, New York
PB - National Student Nurses Association
SN - 0019-3062
AD - US Public Health Service, Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fleming, Michael F.
AU - Manwell, Linda Baier
AU - Kraus, Mark
AU - Isaacson, Harry J.
AU - Kahn, Ruth
AU - Stauffacher, Ellyn A.
T1 - Who teaches residents about the prevention and treatment of substance use disorders?
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1999/09//
VL - 48
IS - 9
M3 - Article
SP - 725
EP - 729
SN - 00943509
AB - BACKGROUND. Studies indicate that physicians are poorly prepared to identify and treat tobacco, alcohol, and drug use disorders. Several faculty development programs have been created to increase the number of residency teaching faculty with expertise in this area. There is limited information, however, on those who currently teach residents about these problems and whether there is a need for additional faculty development programs. METHODS. We conducted a 2-stage national survey of faculty who teach residents about substance use problems. First, residency directors from 7 specialties (family medicine, psychiatry, internal medicine, pediatrics, obstetrics and gynecology, emergency medicine, and osteopathy) responded to a mailed questionnaire asking them to identify faculty who teach residents about substance use disorders. Second, those identified were contacted and asked to participate in a telephone interview. RESULTS. Of 1293 faculty identified by the residency directors, 769 participated in a research interview. Most of these teachers were full-time physician faculty, men, white, and based in departments of family medicine or psychiatry. Teaching was primarily conducted in hospitals, general outpatient clinics, and classrooms rather than alcohol and drug treatment programs. Less than 10% of the faculty performed clinical work in alcohol and drug treatment programs, and only 19% were certified addiction specialists. The respondents reported a definite need for additional development programs for themselves and other residency teaching faculty. CONCLUSIONS. We suggest a modest increase in the number of faculty who teach residents about substance abuse disorders, and the creation of additional faculty development programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Treatment
KW - PHYSICIANS
KW - MEDICAL personnel
KW - FAMILY medicine
KW - PATHOLOGICAL psychology
KW - PERSONALITY disorders
KW - Faculty
KW - medical
KW - schools
KW - schools, medical
KW - substance use disorders
N1 - Accession Number: 2356211; Fleming, Michael F. 1; Email Address: mfleming@fammed.wisc.edu; Manwell, Linda Baier 1; Kraus, Mark 2; Isaacson, Harry J. 3; Kahn, Ruth 4; Stauffacher, Ellyn A. 1; Source Information: Sep1999, Vol. 48 Issue 9, p725; Subject: DRUG abuse -- Treatment; Subject: PHYSICIANS; Subject: MEDICAL personnel; Subject: FAMILY medicine; Subject: PATHOLOGICAL psychology; Subject: PERSONALITY disorders; Author-Supplied Keyword: Faculty; Author-Supplied Keyword: medical; Author-Supplied Keyword: schools; Author-Supplied Keyword: schools, medical; Author-Supplied Keyword: substance use disorders; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Teisl, Mario F.
AU - Levy, Alan S.
AU - Derby, Brenda M.
T1 - The Effects of Education and Information Source on Consumer Awareness of Diet-Disease Relationships.
JO - Journal of Public Policy & Marketing
JF - Journal of Public Policy & Marketing
Y1 - 1999///Fall99
VL - 18
IS - 2
M3 - Article
SP - 197
EP - 207
PB - American Marketing Association
SN - 07439156
AB - Information about diet--disease relationships provided by the news media is associated with increases in consumer awareness of these relationships. However, consumer awareness levels have declined during time periods when nutrient information increasingly was provided in food advertising. People with higher (lower) education levels were more (less) aware of diet--disease relationships. In general, the authors do not find strong evidence that media- or firm-provided information decreases the difference in awareness between more and less educated persons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Policy & Marketing is the property of American Marketing Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Consumers
KW - Mass media
KW - Education
KW - Diet
KW - Health
KW - Food
KW - Nutrition
KW - Food habits
KW - Diseases -- Risk factors
N1 - Accession Number: 2595270; Teisl, Mario F. 1; Levy, Alan S. 2; Derby, Brenda M. 3; Affiliations: 1: Assistant professor, Department of Resource Economics and Policy, University of Maine; 2: Chief, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; 3: Statistician, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; Issue Info: Fall99, Vol. 18 Issue 2, p197; Thesaurus Term: Consumers; Thesaurus Term: Mass media; Thesaurus Term: Education; Subject Term: Diet; Subject Term: Health; Subject Term: Food; Subject Term: Nutrition; Subject Term: Food habits; Subject Term: Diseases -- Risk factors; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Vulule, J. M.
AU - Beach, R. F.
AU - Atieli, F. K.
AU - Mcallister, J. C.
AU - Brogdon, W. G.
AU - Roberts, J. M.
AU - Mwangi, R. W.
AU - Hawley, W. A.
T1 - Elevated oxidase and esterase levels associated with permethrin tolerance in Anopheles gambiae from Kenyan villages using permethrin-impregnated nets.
JO - Medical & Veterinary Entomology
JF - Medical & Veterinary Entomology
Y1 - 1999/09//
VL - 13
IS - 3
M3 - Article
SP - 239
EP - 244
PB - Wiley-Blackwell
SN - 0269283X
AB - SummaryThe permethrin tolerance (PT) of a population of the mosquito Anopheles gambiae (Diptera: Culicidae) increased following the introduction of permethrin-impregnated nets for malaria control in certain villages near Kisumu, western Kenya. Using a biochemical test that indirectly measures oxidases associated with permethrin resistance, we found that this population had higher oxidase levels than a comparison population from villages without impregnated nets. Mosquitoes from a colony of An. gambiae selected for PT, the RSP (reduced susceptibility to permethrin) strain, were exposed to permethrin with or without the oxidase inhibitor piperonyl butoxide (PB). Significantly higher mortality rates occurred when permethrin was synergized by PB, presumably by suppression of oxidases responsible for PT. An unselected (UNS) colony of An. gambiae that was more susceptible than RSP in a permethrin-susceptibility bioassay (i.e. LT50 22 min for UNS, vs. 42 min for RSP) was compared with the RSP colony for levels of oxidases and esterases. The levels of both enzymes were very significantly higher in the RSP strain (P < 0.0001). We speculate that use of impregnated nets selected for higher oxidase and esterase levels in An. gambiae to metabolize permethrin acquired from the nets. Both oxidase and esterase mechanisms could confer cross-resistance to other pyrethroids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical & Veterinary Entomology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pests -- Control
KW - Anopheles
KW - Oxidases
KW - Esterases
KW - Malaria -- Prevention
KW - Kenya
KW - Anopheles gambiae
KW - bednets
KW - bioassays
KW - biochemical assays
KW - esterases
KW - insecticide tolerance
KW - permethrin
N1 - Accession Number: 5168467; Vulule, J. M. 1; Beach, R. F. 2; Atieli, F. K. 1; Mcallister, J. C. 2; Brogdon, W. G. 2; Roberts, J. M. 2; Mwangi, R. W. 3; Hawley, W. A. 2; Affiliations: 1: Vector Biology and Control Research Centre (Kenya Medical Research Institute), PO Box 1578, Kisumu, Kenya,; 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health & Human Services, Atlanta, GA, U.S.A, and; 3: Department of Zoology, University of Nairobi, Kenya; Issue Info: Sep99, Vol. 13 Issue 3, p239; Thesaurus Term: Pests -- Control; Subject Term: Anopheles; Subject Term: Oxidases; Subject Term: Esterases; Subject Term: Malaria -- Prevention; Subject: Kenya; Author-Supplied Keyword: Anopheles gambiae; Author-Supplied Keyword: bednets; Author-Supplied Keyword: bioassays; Author-Supplied Keyword: biochemical assays; Author-Supplied Keyword: esterases; Author-Supplied Keyword: insecticide tolerance; Author-Supplied Keyword: permethrin; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; Number of Pages: 7p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2915.1999.00177.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107215101
T1 - Device safety. Clamping down on circumcision.
AU - Swayze S
Y1 - 1999/09//
N1 - Accession Number: 107215101. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Circumcision -- Adverse Effects
KW - Surgical Instruments -- Adverse Effects -- In Infancy and Childhood
KW - Equipment Safety
KW - Tears and Lacerations -- Etiology -- In Infancy and Childhood
KW - Infant, Newborn
KW - Male
SP - 73
EP - 73
JO - Nursing
JF - Nursing
JA - NURSING
VL - 29
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 10540626.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Antonini, James M.
AU - Charron, Tina G.
AU - Roberts, Jenny R.
AU - Lai, Jean
AU - Blake, Terri L.
AU - Rogers, Rick A.
T1 - Application of laser scanning confocal microscopy in the analysis of particle-induced pulmonary fibrosis.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 1999/09//
VL - 51
IS - 1
M3 - Article
SP - 126
EP - 134
PB - Oxford University Press / USA
SN - 10966080
AB - Laser scanning confocal microscopy (LSCM) allows us to simultaneously quantitate the degree of lung fibrosis and distinguish various pathological lesions of intact lung tissue. Lucifer Yellow has been shown an ideal fluorescent stain to examine the connective tissue matrix components of embedded lung tissue with LSCM. We evaluated the use of LSCM in quantitating lung fibrosis and compared this procedure with the more traditional method of assessing fibrosis by measuring hydroxyproline, a biochemical assay of collagen. CD/VAF rats were intratracheally dosed with silica (highly fibrogenic), Fe2O3 (non-fibrogenic), and saline (vehicle control) at a high dose of 10-mg/100 g body weight. At 60 days post-instillation, the left lung was dissolved in 6 M HCl and assayed for hydroxyproline. Silica induced increases of 58% and 94% in hydroxyproline content over the Fe2O3 and control groups, respectively. The right lung lobes were fixed, sectioned into blocks, dehydrated, stained with Lucifer Yellow (0.1 mg/ml), and embedded in Spurr plastic. Using LSCM and ImageSpace software, the tissue areas of ten random scans from ten blocks of tissue for each of the three groups were measured, and three-dimensional reconstructions of random areas of lung were generated. The silica group showed increases of 57% and 60% in the lung areas stained by Lucifer Yellow over the Fe2O3 and control groups, respectively. Regression analysis of hydroxyproline vs. lung tissue area demonstrated a significant positive correlation (p<0.05) with a correlation coefficient of 0.91. Histological analysis of right lung tissue revealed a marked degree of granulomatous interstitial pneumonitis for the silica group, which was absent in the Fe2O3 and control groups. No significant differences (p<0.05) in hydroxyproline content and measured tissue area were observed between the Fe2O3 and control groups. LSCM, and its associated advanced image analysis and three-dimensional capabilities, is an alternative method to both quickly quantitate and examine fibrotic lung disease without physical disruption of the tissue specimen. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Confocal microscopy
KW - Fibrosis
KW - Lungs
KW - Pulmonary fibrosis
KW - Silica
KW - confocal microscopy
KW - hydroxyproline
KW - hydroxyproline.
KW - Lucifer Yellow
KW - lung fibrosis
KW - silica
N1 - Accession Number: 44405814; Antonini, James M. 1; Email Address: jga6@cdc.gov; Charron, Tina G. 1; Roberts, Jenny R. 2; Lai, Jean 2; Blake, Terri L. 1; Rogers, Rick A. 2; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 2: Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115; Issue Info: Sep1999, Vol. 51 Issue 1, p126; Thesaurus Term: WOUNDS & injuries; Subject Term: Confocal microscopy; Subject Term: Fibrosis; Subject Term: Lungs; Subject Term: Pulmonary fibrosis; Subject Term: Silica; Author-Supplied Keyword: confocal microscopy; Author-Supplied Keyword: hydroxyproline; Author-Supplied Keyword: hydroxyproline.; Author-Supplied Keyword: Lucifer Yellow; Author-Supplied Keyword: lung fibrosis; Author-Supplied Keyword: silica; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 9p; Illustrations: 1 Color Photograph, 4 Black and White Photographs, 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 1999-11883-003
AN - 1999-11883-003
AU - Taylor, Timothy L.
AU - Denny, Clark H.
AU - Freeman, William L.
T1 - American Indian and Alaska native trends in behavioral health, 1990–1996.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 1999/09//Sep-Oct, 1999
VL - 23
IS - 5
SP - 345
EP - 351
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
N1 - Accession Number: 1999-11883-003. Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Taylor, Timothy L.; Indian Health Service, Alcoholism & Substance Abuse Program, Albuquerque, NM, US. Release Date: 19991201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Health Behavior; Risk Assessment. Classification: Personality Psychology (3100). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study. Page Count: 7. Issue Publication Date: Sep-Oct, 1999.
AB - Analyzed and evaluated American Indian trends in behavioral risk for the period 1990–1996. 7,037 adults (aged 18–60+ yrs) participated in this study. Data on 5 health behaviors were drawn from the 1990–1996 Behavioral Risk Factor Surveillance System (BRFSS) representing the 34 states covered by the Indian Health Service. Time trends were analyzed with the use of linear regression. Diabetes increased among Indian men. The average annual percentage-point increase in diabetes awareness among Indian men was 0.4. Greater attention needs to be focused on Indian health-risk behaviors, especially diabetes awareness, as well as the surveillance of related behaviors such as overweight, physical activity, and diet. It is concluded that states should be encouraged and provided resources to improve BRFSS Indian samples. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trends in health behavioral risk
KW - 18–60+ yr old American Indians & Alaska natives
KW - 1999
KW - Alaska Natives
KW - American Indians
KW - Health Behavior
KW - Risk Assessment
KW - 1999
DO - 10.5993/AJHB.23.5.3
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2014-10391-002
AN - 2014-10391-002
AU - Jones, John G.
T1 - Mental health intervention in the aftermath of a mass casualty disaster.
JF - Traumatology
JO - Traumatology
JA - Traumatology (Tallahass Fla)
Y1 - 1999/09//
VL - 5
IS - 3
CY - US
PB - Academy of Traumatology
SN - 1534-7656
SN - 1085-9373
AD - Jones, John G., Indian Health Service, Fort Peck Service Unit, Wolf Point, MT, US
N1 - Accession Number: 2014-10391-002. Other Journal Title: Traumatology: An International Journal. Partial author list: First Author & Affiliation: Jones, John G.; Indian Health Service, Fort Peck Service Unit, Wolf Point, MT, US. Other Publishers: Educational Publishing Foundation; Green Cross Project; Sage Publications. Release Date: 20150427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Disasters; Intervention; Mental Health. Minor Descriptor: Art Therapy; Group Psychotherapy; Psychotherapy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. References Available: Y. Issue Publication Date: Sep, 1999.
AB - The purpose of this paper is to share ideas and techniques employed in an effort to provide mental health intervention following a mass casualty disaster. The information presented in this paper comes primarily from work done with the survivors of the bombing of the federal office building in Oklahoma City, OK, on April 19, 1995. One hundred sixty-nine people died and over 500 were injured at 9:02 of that day. Each of these individuals had families, loved ones, friends, fishing buddies, and multiple acquaintances, and the ripples of trauma generated by this powerful blast were felt nation wide and around the world. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health intervention
KW - mass casualty disaster
KW - individual therapy
KW - group therapy
KW - art therapy
KW - traditional healing
KW - 1999
KW - Death and Dying
KW - Disasters
KW - Intervention
KW - Mental Health
KW - Art Therapy
KW - Group Psychotherapy
KW - Psychotherapy
KW - 1999
DO - 10.1177/153476569900500302
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UR - jjones@bilb2.billings.ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107220057
T1 - Framework for program evaluation in public health.
AU - Milstein RL
AU - Wetterhall S
Y1 - 1999/09/18/9/17/1999 Supplement RR-11
N1 - Accession Number: 107220057. Language: English. Entry Date: 19991101. Revision Date: 20151019. Publication Type: Journal Article; algorithm; CEU; exam questions; tables/charts. Supplement Title: 9/17/1999 Supplement RR-11. Journal Subset: Biomedical; Public Health; USA. NLM UID: 7802429.
KW - Public Health
KW - Program Evaluation -- Methods
KW - Conceptual Framework
KW - Education, Continuing (Credit)
SP - 1
EP - 8
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
JA - MMWR MORB MORTAL WKLY REP
VL - 48
IS - 36
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - Effective program evaluation is a systematic way to improve and account for public health actions by involving procedures that are useful, feasible, ethical, and accurate. The framework guides public health professionals in their use of program evaluation. It is a practical, nonprescriptive tool, designed to summarize and organize essential elements of program evaluation. The framework comprises steps in program evaluation practice and standards for effective program evaluation. Adhering to the steps and standards of this framework will allow an understanding of each program's context and will improve how pro-gram evaluations are conceived and conducted. Furthermore, the framework encourages an approach to evaluation that is integrated with routine program operations. The emphasis is on practical, ongoing evaluation strategies that involve all program stakeholders, not just evaluation experts. Understanding and applying the elements of this framework can be a driving force for planning effective public health strategies, improving existing programs, and demonstrating the results of resource investments.
SN - 0149-2195
AD - US Department of Health and Human Services. Centers for Disease Control and Prevention
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107147590
T1 - Coffee, alcohol, and the liver.
AU - Sharp DS
AU - Everhart JE
AU - Benowitz NL
Y1 - 1999/10//1999 Oct
N1 - Accession Number: 107147590. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013.
KW - Coffee
KW - Alcohol Abuse -- Complications
KW - Liver Diseases -- Etiology
KW - Caffeine -- Blood
KW - Liver Cirrhosis, Alcoholic
KW - Gamma-Glutamyltransferase -- Blood
KW - Alanine Aminotransferase -- Blood
KW - Clinical Trials
KW - Sex Factors
KW - Male
KW - Female
SP - 391
EP - 393
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 9
IS - 7
CY - New York, New York
PB - Elsevier Science
SN - 1047-2797
AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Biostatistics Branch, 1095 Willowdale Rd MS4020, Morgantown, WV 26505
U2 - PMID: 10501405.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Satterthwaite, Peter
AU - Pritchard, Kathy
AU - Floyd, Diane
AU - Law, Bonnie
T1 - A case-control study of Yersinia enterocolitica infections in Auckland.
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 1999/10//
VL - 23
IS - 5
M3 - Article
SP - 482
EP - 486
SN - 13260200
AB - The article discusses a research study, which identifies major risk factors for Yersinia enterocoIitica (YE) and identifies measures to reduce YE infections in Auckland, New Zealand. This study has compared people who have recently had YE infections with randomly selected controls for socio-demographic factors and the exposures to environmental, dietary and food handling practices. The significant exposures found in this study explain most of the increased risk for obtaining YE illness. This study has confirmed the results of other studies that pork is more commonly eaten by people who have YE infections. The lower rate of consumption among cases of cured or treated meats such as bacon and smailgoods suggests that these forms of meat preparation may decontaminate meats contaminated with YE. YE is very heat sensitive and can be inhibited by 5-10% sodium chloride. The results of this study suggest potential ways in which YE may be entering the human food chain. Some specific investigations are recommended to enable practical interventions to prevent YE infections.
KW - YERSINIA enterocolitica infections
KW - PORK
KW - FOOD habits
KW - FOOD handling
KW - AUCKLAND (N.Z.)
KW - NEW Zealand
N1 - Accession Number: 2622356; Satterthwaite, Peter 1; Email Address: peter.satterthwaite@bigfoot.com; Pritchard, Kathy 1; Floyd, Diane 1; Law, Bonnie 2; Affiliations: 1: Auckland Public Health Service, New Zealand.; 2: Department of Statistics, Auckland University, New Zealand.; Issue Info: Oct99, Vol. 23 Issue 5, p482; Subject Term: YERSINIA enterocolitica infections; Subject Term: PORK; Subject Term: FOOD habits; Subject Term: FOOD handling; Subject: AUCKLAND (N.Z.); Subject: NEW Zealand; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; NAICS/Industry Codes: 311612 Meat Processed from Carcasses; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107230019
T1 - From the Food and Drug Administration. Important drug information: immune globulin intravenous (human)
AU - Epstein JS
AU - Gaines A
AU - Kapit R
AU - Pierce R
AU - Potter R
AU - Varricchio F
Y1 - 1999/10//1999 Oct-Dec
N1 - Accession Number: 107230019. Language: English. Entry Date: 19991201. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Immunoglobulins, Intravenous -- Adverse Effects
KW - Kidney Failure, Acute -- Chemically Induced
KW - Sucrose -- Adverse Effects
KW - Pharmaceutical Additives -- Adverse Effects
KW - Kidney Failure, Acute -- Prevention and Control
SP - 139
EP - 140
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 5
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 10661146.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107230019&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107138798
T1 - Cancer screening among community health center women: eliminating the gaps.
AU - Regan J
AU - Lefkowitz B
AU - Gaston MH
Y1 - 1999/10//
N1 - Accession Number: 107138798. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 7802876.
KW - Cancer Screening -- Utilization
KW - Community Health Centers
KW - Female
KW - Cervical Smears
KW - Mammography
KW - Breast Examination
KW - Adult
KW - Middle Age
KW - Ethnic Groups
KW - Socioeconomic Factors
KW - Surveys
KW - Questionnaires
KW - Interviews
KW - Data Analysis Software
KW - Human
SP - 45
EP - 52
JO - Journal of Ambulatory Care Management
JF - Journal of Ambulatory Care Management
JA - J AMBULATORY CARE MANAGE
VL - 22
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: The elimination of health status gaps among minority and low income populations is part of the mission of community health centers (CHCs). Cervical and breast cancer incidence and mortality are related to both minority and socioeconomic status, and CHCs are in a unique position, by virtue of their target population, to effect positive outcomes through screening and early detection. Methods: Completed in 1995, the survey described in this article included questions from the 1992 NHIS Cancer Supplement, which collected information on the utilization of cancer-screening services, including Pap smear testing, mammography, and clinical breast examination. Results: CHCs are providing access to Pap smear testing, mammography, and clinical breast examination for women who are at an increased risk for morbidity and mortality associated with cancers of the cervix and breast. A higher proportion of CHC women of most racial and ethnic groups and women below poverty level are up to date on cancer screening than comparison groups. In most cases, CHIC women meet or exceed the Healthy People 2000 objectives for the nation. Copyright © 2000 by Aspen Publishers, Inc.
SN - 0148-9917
AD - Deputy Director, Office of Data, Evaluation, Analysis and Research, Bureau of Primary Health Care, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, Maryland
U2 - PMID: 11184888.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107138798&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107229324
T1 - Child health policy. Children with special health-care needs: access to care.
AU - Forsman I
A2 - Velsor-Friedrich B
A2 - Ferguson SL
Y1 - 1999/10//1999 Oct
N1 - Accession Number: 107229324. Language: English. Entry Date: 19991201. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8607529.
KW - Child, Disabled
KW - Health Services Accessibility -- In Infancy and Childhood
KW - Child Health Services
KW - Child
KW - Health Policy -- United States
KW - Government Agencies -- United States
KW - United States
KW - Child Health
KW - Continuity of Patient Care -- In Infancy and Childhood
KW - Family Centered Care
SP - 336
EP - 338
JO - Journal of Pediatric Nursing
JF - Journal of Pediatric Nursing
JA - J PEDIATR NURS
VL - 14
IS - 5
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0882-5963
AD - Nurse Consultant, Division of Services for Children with Special Health Care Needs, Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18A18, Rockville, MD 20857
U2 - PMID: 10554447.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107089918
T1 - Infant formula preparation, handling, and related practices in the United States.
AU - Fein SB
AU - Falci CD
Y1 - 1999/10//
N1 - Accession Number: 107089918. Language: English. Entry Date: 20000201. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Infant Formula
KW - Food Handling
KW - Mothers
KW - Infant Feeding
KW - Infant
KW - Adult
KW - Logistic Regression
KW - Prospective Studies
KW - United States
KW - Female
KW - Questionnaires
KW - Mothers -- Education
KW - Infant Formula -- Education
KW - Human
SP - 1234
EP - 1240
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 99
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-727, 200 C St SW, Washington, DC 20204
U2 - PMID: 10524388.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107089918&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107090485
T1 - Taking issue. How well are we evaluating system change?
AU - Leginski W
AU - Randolph F
AU - Rog DJ
Y1 - 1999/10//
N1 - Accession Number: 107090485. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Mental Health Services -- Standards
KW - Psychiatry
KW - United States
SP - 1257
EP - 1257
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 50
IS - 10
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Center for Mental Health Services, Rockville, MD
U2 - PMID: 10506291.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107090485&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - de Rosa, C.T.
AU - Brown, D.
AU - Dhara, R.
AU - Garrett, W.
AU - Hansen, H.
AU - Holler, J.
AU - Jones, D.
AU - Jordan-Izaguirre, D.
AU - O'conner, R.
AU - Pohl, H.
AU - Xintaras, C.
T1 - Dioxin and dioxin-like compounds in soil, Part I: ATSDR policy guideline.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/10//
VL - 15
IS - 6
M3 - Article
SP - 552
EP - 557
PB - Sage Publications, Ltd.
SN - 07482337
KW - dioxin
KW - human exposure
KW - risk assessment
KW - SOIL LEVELS
KW - TCDD
KW - TEQs
N1 - Accession Number: 2596482; de Rosa, C.T. 1; Brown, D. 1; Dhara, R. 1; Garrett, W. 1; Hansen, H. 1; Holler, J. 1; Jones, D. 1; Jordan-Izaguirre, D. 1; O'conner, R. 1; Pohl, H. 1; Xintaras, C. 1; Affiliations: 1: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia; Issue Info: 1999, Vol. 15 Issue 6, p552; Author-Supplied Keyword: dioxin; Author-Supplied Keyword: human exposure; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: SOIL LEVELS; Author-Supplied Keyword: TCDD; Author-Supplied Keyword: TEQs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107149819
T1 - Review: high-dose inhaled corticosteroids increase the risk for some systemic adverse effects in asthma...commentary on Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy. A systematic review and meta-analysis. ARCH INTERN MED 1999 May 10;159:941-55
AU - Honig PK
Y1 - 1999/11//1999 Nov-Dec
N1 - Accession Number: 107149819. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Adrenal Cortex Hormones -- Administration and Dosage
KW - Adrenal Cortex Hormones -- Adverse Effects
KW - Asthma -- Drug Therapy
KW - Administration, Inhalation
KW - Systematic Review
KW - Meta Analysis
KW - Clinical Trials
KW - Cross Sectional Studies
KW - Prospective Studies
KW - Adrenal Glands -- Drug Effects
KW - Growth -- Drug Effects
KW - Bone Density -- Drug Effects
KW - Eye Diseases
KW - Contusions and Abrasions
KW - Dose-Response Relationship, Drug
KW - Data Analysis, Statistical
KW - Child
KW - Adult
SP - 78
EP - 78
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 131
IS - 3
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - U.S. Food and Drug Administration, Rockville, Maryland
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107149819&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Partin, Melissa R.
AU - Rith-Najarian, Stephen J.
AU - Slater, Jonathan S.
AU - Korn, Jane E.
AU - Cobb, Nathaniel
AU - Soler, John T.
T1 - Improving Cancer Incidence Estimates for American Indians in Minnesota.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/11//
VL - 89
IS - 11
M3 - Article
SP - 1673
EP - 1677
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of this study was to estimate cancer incidence for American Indians in Minnesota. Methods. Indian Health Service enrollment data were linked to the Minnesota tumor registry to identify cancers among American Indians in Minnesota. Incidence rates for the 5 most common cancers in this population, estimated after the linkage, were compared with rates estimated before the linkage and with rates for the total population of Minnesota. Results. The linkage identified 302 cancer cases not previously identified as occurring among American Indians in Minnesota. Postlinkage estimates suggested that incidence rates for prostate and colorectal cancer are similar to those for the total population of Minnesota, but that rates of lung and cervical cancer are significantly higher. Breast cancer rates are slightly lower than those for the total population of Minnesota but more than twice as high as previous estimates for American Indians. Conclusions. The postlinkage estimates suggest different priorities for cancer education, prevention, and control than might be assumed from either prelinkage estimates or previously published data, and underscore the importance offing accurate and specific data for setting these priorities. (Am J Public Health. 1999;89:1673-1677) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health
KW - Cancer
KW - Indigenous peoples of the Americas
KW - Minnesota
KW - United States
N1 - Accession Number: 2456250; Partin, Melissa R. 1,2; Email Address: melissa.partin@med.va.gov; Rith-Najarian, Stephen J. 3; Slater, Jonathan S. 1; Korn, Jane E. 1; Cobb, Nathaniel 4; Soler, John T. 1; Affiliations: 1: Minnesota Department of Health, Minneapolis; 2: Minneapolis VA Medical Center; 3: Indian Health Service, Albuquerque, NM.; 4: Indian Health Service, Bemidji, Minn.; Issue Info: Nov99, Vol. 89 Issue 11, p1673; Thesaurus Term: Health; Subject Term: Cancer; Subject Term: Indigenous peoples of the Americas; Subject: Minnesota; Subject: United States; Number of Pages: 5p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article; Full Text Word Count: 4291
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107091485
T1 - Information management. Satellite videoconferencing for healthcare workers: audience characteristics and the importance of continuing education credits.
AU - Chen I
AU - Eckhardt JN
AU - Sinkowitz-Cochran RL
AU - Jarvis WR
Y1 - 1999/11//1999 Nov
N1 - Accession Number: 107091485. Language: English. Entry Date: 20000301. Revision Date: 20150818. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Teleconferencing -- Evaluation
KW - Education, Continuing
KW - Attitude of Health Personnel
KW - Evaluation Research
KW - Convenience Sample
KW - Surveys
KW - Attitude Measures
KW - Telephone
KW - Descriptive Research
KW - Drug Resistance, Microbial -- Education
KW - Antibiotics
KW - Drug Utilization -- Education
KW - Health Personnel
KW - Human
SP - 778
EP - 780
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 20
IS - 11
PB - Cambridge University Press
AB - To assess the opinions of healthcare workers (HCWs) about a satellite videoconference as a means of earning continuing education credit, a telephone survey was conducted in September 1998, 1 month after a live interactive satellite videoconference on antimicrobial use and resistance. There were 180 registered sites in 45 states surveyed, representing 1,589 viewers: 764 nurses (48.1%), 201 physicians (12.6%), and 624 other HCWs (39.3%). Continuing education credit was requested by 51% of nurses, 31% of physicians, and 27% of all other HCWs. Although preferred learning formats varied, 70% of respondents said it was important to offer continuing education credit. Furthermore, 31% of the respondents stated that the videoconference influenced institutional strategies. We concluded that satellite videoconferences are a method to reach audiences around the world efficiently and effectively, provide the latest information, facilitate interaction, and meet some of the demand for continuing education credit for HCWs.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 10580632.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107091485&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107088346
T1 - Safety and regulatory issues in anabolic agents' use and development...Proceedings from A.S.P.E.N.'s 23rd Clinical Congress Research Workshop, January 31, 1999, San Diego, California
AU - Malozowski S
AU - Malozowski, S
AU - Koller, E
A2 - Koller E
Y1 - 1999/11//
N1 - Accession Number: 107088346. Language: English. Entry Date: 20000201. Revision Date: 20170223. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7804134.
KW - Growth Substances -- Adverse Effects
KW - Growth Substances -- Therapeutic Use
KW - Legislation, Drug
SP - S214
EP - 5
JO - JPEN Journal of Parenteral & Enteral Nutrition
JF - JPEN Journal of Parenteral & Enteral Nutrition
JA - JPEN J PARENTER ENTERAL NUTR
VL - 23
IS - 6
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 0148-6071
AD - Division of Endocrine and Metabolic Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20857, USA
AD - Division of Endocrine and Metabolic Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 10571458.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107088346&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107152997
T1 - Alaska's model program for surveillance and prevention of occupational injury deaths.
AU - Conway GA
AU - Lincoln JM
AU - Husberg BJ
AU - Manwaring JC
AU - Klatt ML
AU - Thomas TK
Y1 - 1999/11//Nov/Dec99
N1 - Accession Number: 107152997. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Occupational-Related Injuries -- Prevention and Control -- Alaska
KW - Disease Surveillance -- Methods
KW - Program Development -- Methods
KW - Occupational-Related Injuries -- Trends -- Alaska
KW - Alaska
KW - Occupational-Related Injuries -- Epidemiology
KW - National Institute for Occupational Safety and Health
KW - Interinstitutional Relations
KW - Public Health Administration
KW - Collaboration
KW - Case Studies
SP - 550
EP - 558
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 114
IS - 6
PB - Sage Publications Inc.
AB - The National Institute for Occupational Safety and Health (NIOSH) established its Alaska Field Station in Anchorage in 1991 after identifying Alaska as the highest-risk state for traumatic worker fatalities. Since then, the Field Station, working in collaboration with other agencies, organizations, and individuals, has established a program for occupational injury surveillance in Alaska and formed interagency working groups to address the risk factors leading to occupational death and injury in the state. Collaborative efforts have contributed to reducing crash rates and mortality in Alaska's rapidly expanding helicopter logging industry and have played an important supportive role in the substantial progress made in reducing the mortality rate in Alaska's commercial fishing industry (historically Alaska's and America's most dangerous industry). Alaska experienced a 46% overall decline in work-related acute traumatic injury deaths from 1991 to 1998, a 64% decline in commercial fishing deaths, and a very sharp decline in helicopter logging-related deaths. Extending this regional approach to other parts of the country and applying these strategies to the entire spectrum of occupational injury and disease hazards could have a broad effect on reducing occupational injuries.
SN - 0033-3549
AD - Chief, NIOSH Alaska Field Station, Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4230 University Drive, Suite 310, Anchorage, AK 99508. E-mail: gocl@cdc.gov
U2 - PMID: 10670623.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107153001
T1 - Chronicles. A forgotten enemy: PHS's fight against the 1918 influenza pandemic.
AU - Gernhart G
Y1 - 1999/11//Nov/Dec99
N1 - Accession Number: 107153001. Language: English. Entry Date: 20001201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Influenza -- History
KW - Public Health Administration -- History
KW - Disease Outbreaks
KW - War -- History
KW - History of Medicine
KW - Influenza -- Prevention and Control
SP - 559
EP - 561
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 114
IS - 6
PB - Sage Publications Inc.
SN - 0033-3549
AD - Historian, Office of the Public Health Service Historian
U2 - PMID: 10670624.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Shalala, Donna E.
T1 - The 1997-1998 Fedele F. and Iris M. Fauri Memorial Lecture.
JO - Research on Social Work Practice
JF - Research on Social Work Practice
Y1 - 1999/11//
VL - 9
IS - 6
M3 - Speech
SP - 708
EP - 715
SN - 10497315
AB - The article presents the text of the lecture given by Donna E. Shalala, U.S. Secretary for Health and Human Services, at the Power Center for Performing Arts at the University of Michigan, Ann Arbor, Michigan, on September 18, 1997, about the legacy of researchers Fedele F. and Iris Fauri. As the former chancellor of the University of Wisconsin, there is one story about Fedele that Shalala particularly cherish. Apparently, Fedele sometimes joked that salary raises for faculty should be based, at least in small part, on how many children the particular faculty member had to support. Fedele spent so much of his life giving a voice in Washington to the powerless and training a powerful generation of social workers--a profession that will next year celebrate its centennial. The legacy of Fedele and Iris Fauri continues in the scholarly work of institution's faculty-and in the commitment of its graduates to rewrite the fate of poor children. Shalala said that despite her training as an academic and her deep respect for cutting-edge research and scholarship, this will not be a lecture that surveys the latest theories about child welfare and child development.
KW - SHALALA, Donna E., 1941-
KW - UNITED States. Dept. of Health & Human Services
KW - CHILDREN -- United States
KW - FAURI, Fedele
KW - UNIVERSITY of Michigan
KW - ANN Arbor (Mich.)
KW - MICHIGAN
KW - UNITED States
N1 - Accession Number: 2413017; Shalala, Donna E. 1; Source Information: Nov99, Vol. 9 Issue 6, p708; Subject: SHALALA, Donna E., 1941-; Subject: UNITED States. Dept. of Health & Human Services; Subject: CHILDREN -- United States; Subject: FAURI, Fedele; Subject: UNIVERSITY of Michigan; Geographic Terms: ANN Arbor (Mich.); MICHIGAN; UNITED States; Number of Pages: 8p; Document Type: Speech; Full Text Word Count: 3827
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Ostrowski, S.R.
AU - Wilbur, S.
AU - Chou, C-H.S.J.
AU - Pohl, H.R.
AU - Stevens, Y-W.
AU - Allred, P.M.
AU - Roney, N.
AU - Fay, M.
AU - Tylenda, C.A.
T1 - Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/11//
VL - 15
IS - 7
M3 - Article
SP - 602
EP - 644
PB - Sage Publications, Ltd.
SN - 07482337
AB - In support of Superfund re-authorization legislation, the Division of Toxicology of the Agency for Toxic Substances and Disease Registry (ATSDR) prepared a chemical-specific consultation document for Congress that identified those chemicals with carcinogenic, neurological, or developmental adverse effects having a latency period longer than 6 years. The review was limited to the top 50 substances listed on ATSDR's 1997 Priority List of Hazardous Substances (Priority List). Among the top 50 chemicals, a review of the technical literature indicated that 38 (76%) were classified as “reasonably anticipated,” “possibly,” or “probably” capable of causing cancer in humans, based either on human and animal data. Eight chemicals (16%) had well-established cancer latency periods in humans of 6 years or more following exposure. Three substances (6%)—arsenic, creosote, and benzidine—had data indicating latency periods longer than 6 years. The technical literature review likewise confirmed the potential for neurological and developmental effects with a latency of 6 years. Twenty-seven (54%) of the top 50 substances caused acute and/or chronic neurotoxic effects; a number of these also caused neurological effects that persisted beyond 6 years (or the equivalent in animal studies) such as: behavioral problems, neurological deficiencies, reduced psychomotor development, cognitive deficiencies, and reduced IQ. Twenty-eight substances (56%) caused adverse developmental effects in offspring of exposed individuals or animals including increased fetal and infant mortality, decreased birth weights and litter sizes, and growth delays. Latency periods for related chemicals are expected to be similar due to structural and toxicological similarities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Carcinogenesis
KW - Vinyl chloride
KW - Physiology
N1 - Accession Number: 4745658; Ostrowski, S.R. 1; Wilbur, S. 1; Chou, C-H.S.J. 1; Pohl, H.R. 1; Stevens, Y-W. 1; Allred, P.M. 1; Roney, N. 1; Fay, M. 1; Tylenda, C.A. 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia; Issue Info: 1999, Vol. 15 Issue 7, p602; Thesaurus Term: Hazardous substances; Thesaurus Term: Carcinogenesis; Thesaurus Term: Vinyl chloride; Thesaurus Term: Physiology; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 43p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2014-34674-016
AN - 2014-34674-016
AU - Turturro, Angelo
AU - Witt, William W.
AU - Lewis, Sherry
AU - Hass, Bruce S.
AU - Lipman, Ruth D.
AU - Hart, Ronald W.
T1 - Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program.
JF - The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences
JO - The Journals of Gerontology: Series A: Biological Sciences and Medical Sciences
JA - J Gerontol A Biol Sci Med Sci
Y1 - 1999/11//
VL - 54
IS - 11
SP - B492
EP - B501
CY - United Kingdom
PB - Oxford University Press
SN - 1079-5006
SN - 1758-535X
AD - Turturro, Angelo, Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2014-34674-016. PMID: 10619312 Other Journal Title: Journal of Gerontology. Partial author list: First Author & Affiliation: Turturro, Angelo; Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, US. Other Publishers: Gerontological Society of America. Release Date: 20160912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Biological Markers; Intervention; Life Span. Minor Descriptor: Aging; Mice; Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Page Count: 10. Issue Publication Date: Nov, 1999. Publication History: Accepted Date: Jun 28, 1999; First Submitted Date: Jun 1, 1999. Copyright Statement: The Gerontological Society of America. 1999.
AB - The collaborative Interagency Agreement between the National Center for Toxicological Research (NCTR) and the National Institute on Aging (NIA) was aimed at identifying and validating a panel of biomarkers of aging in rodents in order to rapidly test the efficacy and safety of interventions designed to slow aging. Another aim was to provide a basis for developing biomarkers of aging in humans, using the assumption that biomarkers that were useful across different genotypes and species were sensitive to fundamental processes that would extrapolate to humans. Caloric restriction (CR), the only intervention that consistently extends both mean and maximal life span in a variety of species, was used to provide a model with extended life span. C57BI/6NNia, DBA/2JNia, B6D2F1, and B6C3F1 mice and Brown Norway (BN/RijNia), Fischer (F344/NNia) and Fischer × Brown Norway hybrid (F344 × BN F1) rats were bred and maintained on study. NCTR generated data from over 60,000 individually housed animals of the seven different genotypes and both sexes, approximately half ad libitum (AL) fed, the remainder CR. Approximately half the animals were shipped to offsite NIA investigators internationally, with the majority of the remainder maintained at NCTR until they died. The collaboration supplied a choice of healthy, long-lived rodent models to investigators, while allowing for the development of some of the most definitive information on life span, food consumption, and growth characteristics in these genotypes under diverse feeding paradigms. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developing biomarkers
KW - life span
KW - growth characteristics
KW - mice
KW - 1999
KW - Biological Markers
KW - Intervention
KW - Life Span
KW - Aging
KW - Mice
KW - Rats
KW - 1999
DO - 10.1093/gerona/54.11.B492
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-34674-016&site=ehost-live&scope=site
UR - aturturro@nctrJda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Eisenberg, John M.
AU - Eisenberg, J M
T1 - Ten lessons for evidence-based technology assessment.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/11/17/
VL - 282
IS - 19
M3 - journal article
SP - 1865
EP - 1869
SN - 00987484
AB - Suggests guidelines for the assessment of technological advances in the medical field. Need for innovation and flexibility in these assessments; Roles of research and cost; Importance of frequent re-evaulation of quickly changing technology.
KW - MEDICAL innovations
KW - TECHNOLOGY
KW - MEDICAL technology
KW - TECHNOLOGICAL innovations
KW - ALTERNATIVE medicine
KW - COMMUNICATION
KW - FEDERAL government
KW - INTERNATIONAL relations
KW - QUALITY assurance
KW - RISK assessment
KW - EVIDENCE-based medicine
N1 - Accession Number: 2485891; Eisenberg, John M.; Eisenberg, J M 1; Source Information: 11/17/99, Vol. 282 Issue 19, p1865; Subject: MEDICAL innovations; Subject: TECHNOLOGY; Subject: MEDICAL technology; Subject: TECHNOLOGICAL innovations; Subject: ALTERNATIVE medicine; Subject: COMMUNICATION; Subject: FEDERAL government; Subject: INTERNATIONAL relations; Subject: QUALITY assurance; Subject: RISK assessment; Subject: EVIDENCE-based medicine; Number of Pages: 5p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107101733
T1 - Vancomycin use in pediatric neurosurgery patients.
AU - Shah SS
AU - Sinkowitz-Cochran RL
AU - Keyserling HL
AU - Jarvis WR
Y1 - 1999/12//1999 Dec
N1 - Accession Number: 107101733. Language: English. Entry Date: 20000401. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Vancomycin -- Therapeutic Use -- In Infancy and Childhood
KW - Neurosurgery -- In Infancy and Childhood
KW - Vancomycin -- Standards -- In Infancy and Childhood
KW - Vancomycin Resistance
KW - Drug Utilization
KW - Descriptive Research
KW - Cross Sectional Studies
KW - Record Review
KW - Power Analysis
KW - Descriptive Statistics
KW - Data Analysis Software
KW - Random Sample
KW - Academic Medical Centers
KW - Hospitals, Pediatric
KW - Practice Guidelines
KW - Antibiotic Prophylaxis
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Inpatients
KW - Male
KW - Female
KW - Human
SP - 482
EP - 487
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 27
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: The objective of this article is to describe a pediatric neurosurgery patient population receiving vancomycin and examine the indications for and appropriateness of vancomycin use. METHODS: A cross-sectional study was performed on the pediatric neurosurgery patients at Egleston Children's Hospital who received vancomycin from January 1 through December 31, 1996. Vancomycin use was compared with the Centers for Disease Control and Prevention Hospital Infection Control Practices Advisory Committee recommendations for vancomycin use. RESULTS: Thirty patients received 115 doses of vancomycin. The median patient age was 8.0 years, and 17 (56.7%) were male. Vancomycin was used for prophylaxis in 28 (93.3%) patients and empiric therapy in 3 (10.0%) patients; one patient received vancomycin for surgical prophylaxis followed by empiric therapy for suspected meningitis. Vancomycin prophylaxis was initiated after the incision in 6 (21.4%) patients and was continued as prophylaxis for more than one dose in 26 (92.9%) patients. CONCLUSIONS: Vancomycin was used primarily as surgical prophylaxis in pediatric neurosurgery patients, and use was not consistent with the Hospital Infection Control Practices Advisory Committee recommendations. These data suggest that for certain subpopulations, such as pediatric neurosurgery patients, there is a need for more specialized recommendations. Furthermore, prudent vancomycin use is warranted to successfully decrease the risk of further emergence of vancomycin resistance. Because vancomycin use may be prevalent in this population, assessment of vancomycin use in pediatric neurosurgery patients followed by establishment of vancomycin clinical guidelines may help improve the appropriateness of vancomycin use in this population.
SN - 0196-6553
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 10586151.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107101733&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Burke, L. B.;
T1 - Advertising and marketing of drugs: what companies can and can't do
CT - Advertising and marketing of drugs: what companies can and can't do
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1999/12/01/
VL - 34
IS - Dec
SP - PI
EP - 17
AD - Division of Drug Advertising, Marketing and Communication, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 36-13071; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics
N2 - Abstract not available.
KW - ASHP meeting abstracts--pharmaceutical industry, drug marketing;
KW - Advertising--drugs--pharmaceutical industry;
KW - Marketing--drugs--pharmaceutical industry;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Lillie, R.;
T1 - Need for postmarketing drug surveillance
CT - Need for postmarketing drug surveillance
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 1999/12/01/
VL - 34
IS - Dec
SP - PI
EP - 16
AD - Office of Postmarketing Drug Risk Assessment, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA
N1 - Accession Number: 36-13109; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics
N2 - Abstract not available.
KW - ASHP meeting abstracts--postmarketing surveillance;
KW - Postmarketing surveillance--overview;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 107226451
T1 - Testing a model of avoiding environmental tobacco smoke in young adults.
AU - Martinelli AM
Y1 - 1999/12//
N1 - Accession Number: 107226451. Language: English. Entry Date: 19991201. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Health-Promoting Lifestyle Profile (HPLP) (Walker et al); General Self-Efficacy Scale (Sherer et al); ETS Avoidance Scale. NLM UID: 8400753.
KW - Passive Smoking
KW - Nursing Models, Theoretical
KW - Theory Validation
KW - Health Behavior
KW - United States
KW - Pender Health Promotion Model
KW - Convenience Sample
KW - Colleges and Universities -- United States
KW - Students, College
KW - Descriptive Statistics
KW - Regression
KW - Validation Studies
KW - Sex Factors
KW - Self-Efficacy
KW - Scales
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 237
EP - 242
JO - Image: Journal of Nursing Scholarship
JF - Image: Journal of Nursing Scholarship
JA - IMAGE J NURS SCHOLARSH
VL - 31
IS - 3
CY - Indianapolis, Indiana
PB - Sigma Theta Tau International
AB - PURPOSE: To test an explanatory model of gender, self-efficacy, situational influences, and other health-promoting behaviors on the avoidance of environmental tobacco smoke (ETS) in young adults. ETS is a cause of lung cancer, pulmonary disease, and cardiovascular disease. Although young adults are at increased risk for ETS exposure, there are few behavioral studies of ETS exposure and no reported studies of ETS exposure in young adults. Although college students are often exposed to ETS, the college environment offers a setting in which the opportunities for change are substantial. DESIGN: Model-testing. Data are reported on a convenience sample of 136 nonsmoking 18- to 25-year old students in one mid-atlantic U.S. university. This sample of nonsmokers was drawn from a larger sample of 241 smokers and nonsmokers in 1995. Model constructs were based on Pender's health promotion model (HPM). METHODS: The General Self-efficacy Scale, Health Promotion Lifestyle Profile, and ETS Avoidance Scale were used along with items measuring ETS-avoidance efficacy and Living with Smoke. Path analysis was used to test the model. FINDINGS: The trimmed explanatory model showed that 26% of the variance in avoiding ETS was accounted for by gender, having self-efficacy, and ETS-avoidance efficacy, not living with people who smoke, and performing other healthy behaviors. Being female and general self-efficacy indirectly influenced ETS avoidance through their effects on related health promoting behaviors. CONCLUSIONS: The explanatory model of ETS avoidance can provide useful information for the development of interventions to prevent exposure to passive smoke. Given the occurrence of ETS exposure in young adults, longitudinal research using this explanatory model is yielding promising results. Enhancing the self-efficacy of young adults and encouraging healthy lifestyle behaviors may be an important factor in their avoidance of ETS.
SN - 0743-5150
AD - Division of Nursing Parklawn Building, Room 9-36, 5600 Fishers Lane, Rockville, MD 20857. E-mail: amartinelli@hrsa.gov
U2 - PMID: 10528453.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Aoki, I.
AU - Itoh, S.
AU - Yokota, S.
AU - Tanaka, S.‐I.
AU - Ishii, N.
AU - Okuda, K.
AU - Minami, M.
AU - Klinman, D. M.
T1 - Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.
JO - Immunology
JF - Immunology
Y1 - 1999/12//
VL - 98
IS - 4
M3 - Article
SP - 519
EP - 524
SN - 00192805
AB - Summary This work examines the contribution of mast cells to the synergistic enhancement of the T helper 2 (Th2) immune response elicited following simultaneous oral and subcutaneous (s.c.) immunization. The s.c. route induced a Th1‐biased immune response, characterized by increased interferon‐γ (IFN‐γ) and immunoglobulin G2a (IgG2a) antibody production. In contrast, oral immunization stimulated a primarily Th2‐type response in which interleukin‐4 (IL‐4) and IgG1 antibody production were dominant. Simultaneous immunization also triggered a Th2‐biased response, the magnitude of which exceeded the additive effects of s.c. and oral immunization alone by greater than threefold. To analyse whether mast cells in gut‐associated lymphoid tissue contributed to this synergistic response, mast cell‐deficient mice WBB6F1 ‐w/wv were studied. Whereas the primary response following simultaneously antigen administration was reduced only twofold in these animals compared with wild type controls WBB6F1 ‐ +/+ (suggesting that mast cells were not needed to initiate Th2 immunity), reconstitution with bone‐marrow‐derived mast cells from WBB6F1 ‐+/+ mice resulted in a superoptimal response (suggesting that mast cells contribute to the magnitude and perpetuation of these Th2‐biased responses). [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAST cells
KW - IMMUNE response
KW - T cells
KW - IMMUNIZATION
N1 - Accession Number: 5605297; Aoki, I. 1; Itoh, S. 2; Yokota, S. 2; Tanaka, S.‐I. 3; Ishii, N. 4; Okuda, K. 5; Minami, M. 6; Klinman, D. M. 7; Source Information: Dec99, Vol. 98 Issue 4, p519; Subject: MAST cells; Subject: IMMUNE response; Subject: T cells; Subject: IMMUNIZATION; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2567.1999.00878.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107084850
T1 - CE update -- regulations and accreditation III. New directions in the FDA regulation of In vitro diagnostic devices.
AU - Gutman S
AU - Richter K
Y1 - 1999/12//1999 Dec
N1 - Accession Number: 107084850. Language: English. Entry Date: 20000201. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 0250641.
KW - Reagent Kits, Diagnostic -- Legislation and Jurisprudence
KW - Government Regulations
KW - Education, Continuing (Credit)
KW - United States Food and Drug Administration
SP - 782
EP - 786
JO - Laboratory Medicine
JF - Laboratory Medicine
JA - LAB MED
VL - 30
IS - 12
PB - Oxford University Press / USA
AB - Since 1976, the Food and Drug Administration has been involved actively in the regulation of in vitro diagnostic devices. Regulation involves a series of premarket and postmarket controls designed to assure that tests meet minimum thresholds of performance and are labeled properly. The review program for medical devices recently has undergone a variety of changes to produce more effective use of its regulatory tools.
SN - 0007-5027
AD - Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, HFZ-440, 2098 Gaither Rd, Rockville, MD 20852; e-mail: sig@cdrh.fda.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Alexander, Greg R.
AU - Kogan, Michael D.
AU - Himes, John H.
T1 - 1994–1996 U.S. Singleton Birth Weight Percentiles for Gestational Age by Race, Hispanic Origin, and Gender.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1999/12//
VL - 3
IS - 4
M3 - Article
SP - 225
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives: Establishing and comparing race, ethnic, and gender-specific birth weight percentiles for gestational age is requisite for investigating the determinants of variations in fetal growth. In this study, we calculate percentiles of birth weight for gestational age for the total 1994–1996 U.S. population and contrast these percentiles by racial/ethnic and gender groups. Methods: Single live births to U.S. resident mothers were selected from the 1994–1996 U.S. Natality Files. After exclusions, 5,973,440 non-Hispanic Whites, 1,393,908 non-Hispanic African Americans, 1,683,333 Hispanics, 80,187 Native Americans, and 510,021 other racial/ethnic groups were used to calculate distribution percentiles of birth weight for each gestational age for which there were at least 50 cases to calculate the 50th percentile and 100 cases to calculate the 10th percentile. Results: Fetal growth patterns among the four U.S. racial/ethnic groups varied markedly and, across the gestational age range, there was considerable oscillation in the relative ranking of any one group's birth weight percentile value in comparison to the others. Males had relatively higher birth weight percentile values than females. The proportion of infants with a birth weight value less than 1994–1996 U.S. population's 10th percentile value of birth weight for their corresponding gestational age was 7.87 for non-Hispanic Whites, 15.43 for non-Hispanic African Americans, 9.30 for Hispanics, and 8.81 for Native Americans. Conclusions: While the factors underlying trends and population subgroup differences in fetal growth are unclear, nutrition, smoking habits, health status, and maternal morbidity are possible precursors for part of the variations in patterns of fetal growth. As prenatal care has been touted as a means to reduce the risk of fetal growth restriction at term, assuring the availability and accessibility of comprehensive prenatal care services is viewed as an essential corollary in the effort to improve fetal growth patterns in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIRTH weight
KW - GESTATIONAL age
KW - FETAL development
KW - ETHNIC groups
KW - UNITED States
KW - Birth weight
KW - ethnicity, Hispanic
KW - fetal growth restriction
KW - gender, race
KW - gestational age
KW - large-for-gestational age
KW - small-for-gestational age
N1 - Accession Number: 11307806; Alexander, Greg R. 1; Email Address: greg.alexander@uab.edu; Kogan, Michael D. 2; Himes, John H. 3; Source Information: Dec1999, Vol. 3 Issue 4, p225; Subject: BIRTH weight; Subject: GESTATIONAL age; Subject: FETAL development; Subject: ETHNIC groups; Geographic Terms: UNITED States; Author-Supplied Keyword: Birth weight; Author-Supplied Keyword: ethnicity, Hispanic; Author-Supplied Keyword: fetal growth restriction; Author-Supplied Keyword: gender, race; Author-Supplied Keyword: gestational age; Author-Supplied Keyword: large-for-gestational age; Author-Supplied Keyword: small-for-gestational age; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107169856
T1 - Gambling behaviors of American Indian and non-Indian adolescents.
AU - Zitzow D
Y1 - 1999///1999 Winter
N1 - Accession Number: 107169856. Language: English. Entry Date: 19990301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 9710452.
KW - Gambling -- In Adolescence
KW - Native Americans -- In Adolescence
KW - Descriptive Statistics
KW - Survey Research
KW - Convenience Sample
KW - Comparative Studies
KW - Adolescence
KW - Male
KW - Female
KW - Human
SP - 10
EP - 12
JO - Prevention Researcher
JF - Prevention Researcher
JA - PREV RESEARCHER
VL - 6
IS - 1
CY - Eugene, Oregon
PB - Prevention Researcher
SN - 1086-4385
AD - Clinical Psychologist, Indian Health Service and Northern Plains American Indian
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jing-Shiang Hwang
AU - Chen, James J.
T1 - An Evaluation of Risk Estimation Procedures for Mixtures of Carcinogens.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 1999/12//
VL - 19
IS - 6
M3 - Article
SP - 1071
EP - 1076
SN - 02724332
AB - The estimation of health risks from exposure to a mixture of chemical carcinogens is generally based on the combination of information from several available single compound studies. The current practice of directly summing the upper bound risk estimates of individual carcinogenic components as an upper bound on the total risk of a mixture is known to be generally too conservative. Gaylor and Chen (1996, Risk Analysis) proposed a simple procedure to compute an upper bound on the total risk using only the upper confidence limits and central risk estimates of individual carcinogens. The Gaylor-Chen procedure was derived based on an underlying assumption of the normality for the distributions of individual risk estimates. In this paper we evaluated the Gaylor-Chen approach in terms of the coverage probability. The performance of the Gaylor-Chen approach in terms the coverage of the upper confidence limits on the true risks of individual carcinogens. In general, if the coverage probabilities for the individual carcinogens are all approximately equal to the nominal level, then the Gaylor-Chen approach should perform well. However, the Gaylor-Chen approach can be conservative or anti-conservative if some or all individual upper confidence limit estimates are conservative or anti-conservative. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Health
KW - Health risk assessment
N1 - Accession Number: 11648192; Jing-Shiang Hwang 1; Chen, James J. 2; Affiliations: 1: Institute of Statistical Science Academia Sinica, Taiwan; 2: Division of Biometry and Risk Assessment National Center for Toxicological Research, U.S. Food and Drug Administration, Arkansas; Issue Info: Dec99, Vol. 19 Issue 6, p1071; Thesaurus Term: Carcinogens; Thesaurus Term: Health; Thesaurus Term: Health risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fay, M.
AU - Donohue, J.M.
AU - de Rosa, C.
T1 - Atsdr Evaluation of Health Effects of Chemicals. Vi. Di(2-Ethylhexyl)phthalate.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/12//
VL - 15
IS - 8
M3 - Article
SP - 651
EP - 746
PB - Sage Publications, Ltd.
SN - 07482337
AB - Di(2-ethylhexyl)phthalate (also known as DEHP, bis(2-ethylhexyl)phthalate, or BEHP; CAS Registry Number 117-81-7) is a widely-used plasticizer. It is found in numerous plastic articles, such as paints, inks, floor tiles, upholstery, shower curtains, footwear, plastic bags, food-packaging materials, toys, and medical tubing. Not surprisingly, DEHP appears at many waste sites. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals that are of greatest public health concern at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priority List (NPL) sites. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of ATSDR's profile for DEHP (ATSDR, 1993) into the mainstream scientific literature. An extensive listing of human and animal health effects, organized by route, duration, and endpoint, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, at the behest of Congress and therefore the citizenry, prepares these profiles to inform the public about site contaminants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Phthalate esters
KW - Toxicology
KW - Public health
KW - Plastics
KW - ATSDR
KW - BEHP
KW - Bis(2-ethylhexyl)phthalate
KW - CAS 117-81-7
KW - DEHP
KW - Di(2-ethylhexyl)phthalate
KW - environmental fate
KW - exposure
KW - Health effects
KW - review
KW - toxicokinetics
N1 - Accession Number: 4745629; Fay, M. 1; Donohue, J.M. 2; de Rosa, C. 1; Affiliations: 1: U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Georgia; 2: U.S. Environmental Protection Agency, Office of Water, Washington, D.C.; Issue Info: 1999, Vol. 15 Issue 8, p651; Thesaurus Term: Phthalate esters; Thesaurus Term: Toxicology; Thesaurus Term: Public health; Thesaurus Term: Plastics; Author-Supplied Keyword: ATSDR; Author-Supplied Keyword: BEHP; Author-Supplied Keyword: Bis(2-ethylhexyl)phthalate; Author-Supplied Keyword: CAS 117-81-7; Author-Supplied Keyword: DEHP; Author-Supplied Keyword: Di(2-ethylhexyl)phthalate; Author-Supplied Keyword: environmental fate; Author-Supplied Keyword: exposure; Author-Supplied Keyword: Health effects; Author-Supplied Keyword: review; Author-Supplied Keyword: toxicokinetics; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 326198 All other plastic product manufacturing; NAICS/Industry Codes: 326121 Unlaminated Plastics Profile Shape Manufacturing; NAICS/Industry Codes: 325211 Plastics Material and Resin Manufacturing; NAICS/Industry Codes: 424610 Plastics Materials and Basic Forms and Shapes Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 96p; Illustrations: 1 Black and White Photograph, 13 Diagrams, 14 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Tegafur/Uracil + Calcium Folinate in Colorectal Cancer: Double Modulation of Fluorouracil.
AU - Hoff, P.M.
AU - Lassere, Y.
AU - Pazdur, R.
JO - Drugs
JF - Drugs
Y1 - 1999/12/04/Dec1999 Supplement 3
VL - 58
IS - 6
SP - 77
EP - 83
SN - 00126667
N1 - Accession Number: 9593660; Author: Hoff, P.M.: 1 Author: Lassere, Y.: 1 Author: Pazdur, R.: 2 ; Author Affiliation: 1 Department of Gastrointestinal Medical Oncology and Digestive Diseases, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA: 2 Food and Drug Administration, Division of Oncology Drug Products, Rockville, Maryland, USA; No. of Pages: 7; Language: English; Publication Type: Article; Update Code: 20030425
N2 - The oral chemotherapeutic agent tegafur/uracil (UFT) is the first of a new class of anticancer drugs called dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines. Tegafur/uracil combines uracil with the fluorouracil prodrug tegafur in a 4:1 molar ratio. Uracil competitively inhibits the degradation of fluorouracil, which results in the concentration of fluorouracil remaining at sustained levels in both plasma and tumour. Tegafur/uracil has been commercially available in Japan since 1983 and examined extensively in various tumours. Trials conducted in the US have focused on the combination of tegafur/uracil plus calcium folinate (calcium leucovorin) [ORZEL]. Several phase I and II trials have evaluated the maximum tolerated dose, pharmacokinetics, efficacy, and safety of this combination in the treatment of colorectal cancer. Results have shown that tegafur/uracil at 300 mg/m/day in divided doses given every 8 hours for 28 days provides prolonged exposure to fluorouracil. Furthermore, tegafur/uracil + calcium folinate is well tolerated, with dose-limiting toxicity manifesting as diarrhoea. Compared with intravenous fluorouracil plus folinic acid (leucovorin) regimens, tegafur/uracil + calcium folinate has similar efficacy with less toxicity and is more convenient because it is an oral regimen. Early studies have also shown potential cost savings because of fewer complications. ABSTRACT FROM AUTHOR
KW - *COLON cancer
KW - *DRUG therapy
KW - *ANTINEOPLASTIC agents
KW - URACIL
KW - ORAL medication
KW - Antineoplastics, therapeutic use
KW - Colorectal cancer, treatment
KW - Folinic acid, therapeutic use
KW - Maximum tolerated dose
KW - Oral
KW - Reviews on treatment
KW - Tegafur/uracil, pharmacodynamics
KW - Tegafur/uracil, pharmacokinetics
KW - Tegafur/uracil, therapeutic use
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 107086092
T1 - Internet purchase of prescription drugs: buyer beware.
AU - Henney JE
AU - Shuren JE
AU - Nightingale SL
AU - McGinnis TJ
Y1 - 1999/12/07/
N1 - Accession Number: 107086092. Language: English. Entry Date: 20000201. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - World Wide Web
KW - Drugs, Prescription -- Economics
KW - Economics, Pharmaceutical
KW - Safety
SP - 861
EP - 862
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 131
IS - 11
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 0003-4819
AD - U.S. Food and Drug Administration, Office of the Commissioner, Rockville, MD 20857
U2 - PMID: 10610633.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107086092&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - Gen
ID - 9999-21373-000
AN - 9999-21373-000
AU - Chiou, Shiow-yi
AU - Bhattacharya, Amit
AU - Succop, Paul A.
T1 - Perceived Sense of Slip Rating Scale
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2000///
AD - Chiou, Shiow-yi, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia, United States, 26505
AV - Commercial: No; Permissions: Contact Corresponding Author; Fee: No. Test Items: No
N1 - Accession Number: 9999-21373-000. Acronyms: PSOS. Partial author list: First Author & Affiliation: Chiou, Shiow-yi; National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia, United States. Release Date: 20160314. Correction Date: 20160411. Instrument Type: Rating Scale. Test Location: Table 2, Page 495. Test Format: The Perceived Sense of Slip Rating Scale contains 4 items rated on a 5-point scale.. Language: English. Constructs: Occupational Safety Attitudes; Slip Risk Perception; Classification: Organizational, Occupational, and Career Development (7000). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The Perceived Sense of Slip Rating Scale assesses potential slip hazards in the workplace.
AB - Description: The Perceived Sense of Slip Rating Scale (PSOS; Chiou, Bhattacharya & Succop, 2000) was developed to assess potential slip hazards in the workplace. The PSOS consists of four simple questions. A sample item is, 'How much did you feel yourself slip (i.e., loss of foot traction)?'. Responses to all four items are measured on a 5-point scale, from 'a little' to 'a lot'. A high score implies a high subjective perception of slip and loss of balance. In a study conducted with a sample of industrial workers, the scale was administered, following postural stability tests, to determine PSOS during task performance. The reproducibility of the PSOS scale was tested using baseline data. A repeated measure analysis of variance (ANOVA) was performed to determine the within-subject effects of visit and task on PSOS score. The results showed that no learning trend developed with repeated testing on different days, and that only different tasks were associated with the PSOS scores. The coefficients of variations of the PSOS score among the four different visits ranged from 4.3 to 10%. Workers were able to perceive likely slips due to the change in job-task and surface slipperiness, and this was reflected in their PSOS rating; subjects always slipped when the PSOS rated by the subjects was beyond the ‘‘ceiling’’ value of 4.5. Findings suggest that the PSOS can be used for identifying tasks and workplace areas with potential for slips. Overall, the PSOS is reproducible, easy to use, and can predict postural instability. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Perceived Sense of Slip Rating Scale
KW - Postural Stability
KW - Predictive Validity
KW - Slippery Surfaces
KW - Test Development
KW - Test Reproducibility
KW - Industrial Workers
U5 - Perceived Sense of Slip Rating Scale (PSOS) [Test Development]Evaluation of workers' perceived sense of slip and effect of prior knowledge of slipperiness during task performance on slippery surfaces. (AN: 2016-01194-001 from PsycINFO) Chiou, Shiow-yi; Bhattacharya, Amit; Succop, Paul A.; Oct, 2014. Source: American Industrial Hygiene Association Journal. 61(4), Taylor & Francis, United Kingdom; Oct, 2014; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: United States; Sample: Industrial Workers Keywords: Perceived Sense of Slip Rating Scale; Postural Stability; Predictive Validity; Slippery Surfaces; Test Development; Test Reproducibility; Industrial Workers; Subjects: Blue Collar Workers; Employee Attitudes; Falls; Hazards; Occupational Safety; Organizational and Occupational Measures; Risk Perception; Test Construction; Test Reliability; Test Validity;
DO - 10.1037/t21373-000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-21373-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - pst
ER -
TY - THES
ID - 109875531
T1 - Changes in weight experienced by female inmates in the Federal Bureau of Prisons.
AU - Massie JA
Y1 - 2000/01//
N1 - Accession Number: 109875531. Language: English. Entry Date: 20020830. Revision Date: 20150923. Publication Type: Masters Thesis; research.
KW - Prisoners
KW - Body Mass Index
KW - Weight Control
KW - Retrospective Design
KW - Record Review
KW - T-Tests
KW - Comparative Studies
KW - Female
KW - Human
SP - 91 p
EP - 91 p
JO - Changes in Weight Experienced by Female Inmates in the Federal Bureau of Prisons
JF - Changes in Weight Experienced by Female Inmates in the Federal Bureau of Prisons
PB - Uniformed Services University of the Health Sciences
AB - Weight change among Federal Bureau of Prisons (BOP) female inmates over a three-year period and the length of incarceration. Data were obtained from retrospective record reviews and body mass indexes (BMI) were used to evaluate weight changes. The sample had a statistically significant mean BMI increase over the study period (t=2.05, p=0.04) and for the period of incarceration (t=2.91, p=0.004). In-custody inmates had a significant mean BMI increase (t=2.05, p=0.05) while out-custody inmates had a non-significant mean BMI increase (t=0.90, p=.38). Independent t-tests comparing BMI changes by custody level were not significant (t=0.96, p=0.34). Inmates with shorter sentences (<100 months) had a non-significant decrease in mean BMI (t=0.04, p=0.97) while inmates with longer sentences (>/= 100 months) had a significant increase in mean BMI (t=2.52, p=0.02). Independent t-tests comparing BMI changes by sentence length was not significant for the study period (t=1.13, p=0.26) but was significant for the period of incarceration (t=2.06, p=0.05). Demographic data were collected and trends among inmates by age and ethnicity were compared to trends among the general public.
AV - Order Info: Graduate and Nursing Dissertations at http://pac.lrc.usuhs.mil/
M1 - MSN
AD - United States Public Health Service Nurse Corp
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DP - EBSCOhost
DB - rzh
ER -
TY - THES
ID - 109875521
T1 - A comparison of diabetes management in a federal prison with the National Standards of Care published by the ADA in 1998.
AU - Giroux VA
Y1 - 2000/01//
N1 - Accession Number: 109875521. Language: English. Entry Date: 20020830. Revision Date: 20150923. Publication Type: Masters Thesis; research. Instrumentation: Diabetes Quality Assurance Checklist (DQA).
KW - Diabetes Mellitus -- Therapy
KW - American Diabetes Association -- Standards
KW - Prisoners
KW - Disease Management
KW - Record Review
KW - Descriptive Research
KW - Checklists
KW - Cardiovascular Risk Factors -- Evaluation
KW - Diabetic Patients
KW - Patient Compliance
KW - Human
SP - 59 p
EP - 59 p
JO - Comparison of Diabetes Management in a Federal Prison With the National Standards of Care Published by the Ada in 1998
JF - Comparison of Diabetes Management in a Federal Prison With the National Standards of Care Published by the Ada in 1998
PB - Uniformed Services University of the Health Sciences
AB - Diabetes Mellitus (DM) affects 16 million Americans, or 6.2% of the population, and costs the U.S. $120 billion annually. Specifically, within the Federal Bureau of Prisons (FBOP), DM affects 5.7% of the total inmate population. It is associated with significant morbidity and mortality. It is the leading cause of blindness, non-traumatic lower extremity amputations, and end-stage renal disease. Results of the Diabetes Control and Complications Trial have shown that intensive treatment can significantly reduce the debilitating and costly long-term complications associated with the disease. Managing a chronic illness such as DM can best be accomplished by following nationally recognized standards of care such as those published by the American Diabetes Association (ADA). The purpose of this study was to describe the medical management for inmates diagnosed with DM within the FBOP, and compare this to the national standards of care published by the ADA in 1998. To measure adherence to the ADA standards, this descriptive quantitative study utilized the Diabetes Quality Assurance (DQA) Checklist to perform a chart review in a federal prison outpatient clinic. The DQA Checklist major categories include referrals, blood glucose evaluation, diet and exercise, foot care, cardiovascular risk factors, and laboratory tests. Cardiovascular risk factor assessment, cholesterol and triglyceride measurement, nutrition assessment, opthalmology and ECG referrals were at greater than 87% adherence. However, the degree of adherence was significantly lower in the areas of glycohemoglobin measurement, documented foot exam, HDL and LDL cholesterol measurement.
AV - Order Info: Graduate and Nursing Dissertations at http://pac.lrc.usuhs.mil/
M1 - MSN
AD - United States Public Health Service Nurse Corp
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2004-12701-068
AN - 2004-12701-068
AU - Murphy, Lawrence R.
ED - Kazdin, Alan E.
ED - Kazdin, Alan E., (Ed)
T1 - Employee assistance programs.
T2 - Encyclopedia of Psychology, Vol. 3.
Y1 - 2000///
SP - 182
EP - 183
CY - Washington, DC, US; New York, NY, US
PB - American Psychological Association
PB - Oxford University Press
SN - 1-55798-652-5
N1 - Accession Number: 2004-12701-068. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20040101. Correction Date: 20151221. Publication Type: Encyclopedia (0300). Format Covered: Print. Document Type: Encyclopedia Entry. Book Type: Reference Book. ISBN: 1-55798-652-5, Hardcover. Language: English. Major Descriptor: Employee Assistance Programs. Classification: Personnel Management & Selection & Training (3620). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 2.
AB - This entry includes the following topics: history of employee assistance programs; central practices and services; structure of employee assistance programs; key assumptions and theories; effectiveness of employee assistance programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employee assistance programs
KW - 2000
KW - Employee Assistance Programs
KW - 2000
DO - 10.1037/10518-068
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12701-068&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107101603
T1 - Concise communications. Vancomycin use in pediatric hematology-oncology patients.
AU - Hopkins HA
AU - Sinkowitz-Cochran RL
AU - Rudin BA
AU - Keyserling HL
AU - Jarvis WR
Y1 - 2000/01//2000 Jan
N1 - Accession Number: 107101603. Language: English. Entry Date: 20000401. Revision Date: 20150818. Publication Type: Journal Article; practice guidelines; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Vancomycin -- Therapeutic Use -- In Infancy and Childhood
KW - Vancomycin -- Standards -- In Infancy and Childhood
KW - Oncologic Care -- In Infancy and Childhood
KW - Vancomycin Resistance
KW - Drug Utilization
KW - Cross Sectional Studies
KW - Random Sample
KW - Record Review
KW - Data Analysis Software
KW - Power Analysis
KW - Practice Guidelines
KW - Oncology Care Units
KW - Hematology
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Inpatients
KW - Male
KW - Female
KW - Human
SP - 48
EP - 50
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 21
IS - 1
PB - Cambridge University Press
AB - Across-sectional study was performed of pediatric hematology-oncology patients who received vancomycin; use was compared to the Centers for Disease Control and Prevention (CDC) recommendations for vancomycin use. Thirty-seven patients received 308 doses of vancomycin. AR patients initially received vancomycin as empirical therapy; 100% of this use was not consistent with the CDC recommendations.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333
U2 - PMID: 10656357.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107101603&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107109808
T1 - From the Food and Drug Administration. Pulmonary artery rupture: serious complication associated with pulmonary artery catheters.
AU - Liu C
AU - Webb CC
Y1 - 2000/01//2000 Jan-Mar
N1 - Accession Number: 107109808. Language: English. Entry Date: 20000501. Revision Date: 20150820. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Pulmonary Artery Catheters -- Adverse Effects
KW - Pulmonary Artery -- Injuries
KW - Rupture -- Etiology
KW - Rupture -- Prevention and Control
KW - Catheter Care, Vascular
KW - Risk Factors
KW - Equipment Safety
KW - Product Surveillance
KW - Rupture -- Mortality
KW - Aged, 80 and Over
KW - Female
KW - Age Factors
KW - Sex Factors
KW - Male
KW - Aged
SP - 19
EP - 26
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 6
IS - 1
CY - New York, New York
PB - Elsevier Science
AB - An analysis of the Manufacturer and User Facility Device Experience database of the Food and Drug Administration was conducted to identify adverse event reports associated with pulmonary artery catheter use between 1993 and 1999. Of 714 adverse event reports, there were 48 deaths of which 42 (88%) were related to pulmonary artery rupture. A further analysis of risk factors was conducted and found 'postmenopausal female' was a most significant finding. Further study is recommended to establish a causal relationship.
SN - 1075-4210
AD - Food and Drug Administration, Center for Devices and Radiologic Health, Office of Surveillance and Biometrics, 1350 Piccard Dr, HFZ 520, Rockville, MD 20850
U2 - PMID: 10642409.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107109808&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106989353
T1 - Measuring neighborhood and school environments: perceptual and aggregate approaches.
AU - Hadley-Ives E
AU - Stiffman AR
AU - Elze D
AU - Johnson SD
AU - Dore P
Y1 - 2000/01//
N1 - Accession Number: 106989353. Language: English. Entry Date: 20010112. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Family Satisfaction Scale (Hudson); Diagnostic Interview Schedule (DIS) (Robins et al); Diagnostic Interview Schedule for Children-Revised (DISC-R) (Schafer et al). Grant Information: Funded by the National Institute of Mental Health (#5R24MH50857). NLM UID: 9890976.
KW - Environment
KW - Community Programs
KW - Mental Health -- In Adolescence
KW - Descriptive Statistics
KW - Multiple Regression
KW - Scales
KW - Focus Groups
KW - DSM
KW - Interviews
KW - Coefficient Alpha
KW - Internal Consistency
KW - T-Tests
KW - P-Value
KW - Analysis of Variance
KW - Pearson's Correlation Coefficient
KW - Attitude Measures
KW - Adolescence
KW - Male
KW - Female
KW - Funding Source
KW - Human
SP - 1
EP - 28
JO - Journal of Human Behavior in the Social Environment
JF - Journal of Human Behavior in the Social Environment
JA - J HUM BEHAV SOC ENVIRON
VL - 3
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This paper describes scales measuring perceptions of neighborhood and school quality. The scales are short and easy to administer, and easily understood by respondents. The measure of neighborhood quality (the NegNeb) has high reliability (alpha = .81), correlates with census data, shows sensitivity to change in neighborhood quality, and discriminates among urban neighborhoods. The measure of school quality (the NegEd) correlates to an index of aggregate school problems. Theories posit that the impact of environment on mental health is determined by perception of that environment. A regression model controlling for family and other characteristics showed that perception of neighborhood (as measured by the NegNeb) contributed unique variance to adolescent mental health. Perception of school did not. However, a second regression model showed that perception of school environment contributed unique variance to peer misbehavior, which was the largest predictor of mental health problems in the first equation. In each regression model aggregate measures of neighborhood and school quality contributed less to the model than did perceived measures. Because adolescents' perceptions of their neighborhood and school environments are clearly linked to their mental health and peer environment, researchers interested in effects of neighborhood and school environment should use subjects' perceptions to conceptualize and measure these realities.
SN - 1091-1359
AD - George Warren Brown School of Social Work, Center for Mental Health Services Research, Washington University, One Brookings Drive, Campus Box 1093, St Louis, MO 63130
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107097136
T1 - Challenges in electronic importing of health data.
AU - Burwen DR
AU - Seawright MF
Y1 - 2000/01//
N1 - Accession Number: 107097136. Language: English. Entry Date: 20000301. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Databases, Health
KW - Database Management Software -- Evaluation
KW - Electronic Data Interchange
KW - Tuberculosis -- Epidemiology
KW - Occupational Health
KW - Evaluation Research
KW - Product Evaluation
KW - Descriptive Statistics
KW - Interviews
KW - Questionnaires
KW - Scales
KW - Centers for Disease Control and Prevention (U.S.)
KW - Public Health
KW - Human
SP - 87
EP - 94
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 6
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - Medical Epidemiologist, Division of Tuberculosis Elimination, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia
U2 - PMID: 10724698.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107097136&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107097326
T1 - Food sources of added sweeteners in the diets of Americans.
AU - Guthrie JF
AU - Morton JF
Y1 - 2000/01//
N1 - Accession Number: 107097326. Language: English. Entry Date: 20000301. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Beverages
KW - Food
KW - Sweetening Agents
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Carbonated Beverages
KW - Education, Continuing (Credit)
KW - United States
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Aged
KW - Middle Age
KW - Dietary Carbohydrates -- Administration and Dosage
KW - Dairy Products
KW - Cereals
KW - Human
SP - 43
EP - 51
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 100
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Consumer Science Specialist, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC
U2 - PMID: 10646004.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107097326&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2000-16452-023
AN - 2000-16452-023
AU - Hebert, Meleik A.
AU - O'Callaghan, James P.
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Protein phosphorylation cascades associated with methamphetamine-induced glial activation.
T2 - Neurobiological mechanisms of drugs of abuse: Cocaine, ibogaine, and substituted amphetamines.
T3 - Annals of the New York Academy of Sciences; Vol 914
Y1 - 2000///
VL - 914
SP - 238
EP - 262
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-279-7
SN - 1-57331-280-0
N1 - Accession Number: 2000-16452-023. Partial author list: First Author & Affiliation: Hebert, Meleik A.; Dept of Health & Human Services, Public Health Service, Ctrs for Disease Control & Prevention, Morgantown, WV, US. Release Date: 20001213. Correction Date: 20150713. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-279-7, Hardcover; 1-57331-280-0, Paperback. Language: English. Major Descriptor: Brain Damage; Methamphetamine; Neurochemistry; Phosphorylases; Proteins. Minor Descriptor: Neurotoxins; Phosphorylation. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. Page Count: 25.
AB - Examined the relative contribution of mitogen-activated protein kinase- and Janus kinase-signaling components to reactive gliosis as measured by induction of glial-fibrillary acidic protein (GFAP), following chemical-induced neural damage. At different time points following methamphetamine (METH) administration, female C57BL/6J mice were sacrificed by focused microwave irradiation, a technique that preserves steady-state phosphorylation. Striatal (target) and nontarget (hippocampus) homogenates were assayed for METH-induced changes in markers of dopamine (DA) neuron integrity and differences in the levels of activated phosphoproteins. GFAP upregulation occurred as early as 6 hrs, reaching a 3-fold induction 48 hrs following METH exposure. Neurotoxicant-induced reductions in striatal levels of DA and tyrosine hydroxylase paralleled the temporal profile of GFAP induction. Specific signaling events were found to occur with a time course suggestive of their involvement in the gliotic response. The toxicant-induced activation of these growth-associated signaling cascades suggests that these pathways could be obligatory for the triggering and/or persistence of reactive gliosis and may therefore serve as potential targets for modulation of glial response to neural damage. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - protein phosphorylation cascades associated with methamphetamine-induced glial activation following chemical-induced neural damage
KW - female mice
KW - 2000
KW - Brain Damage
KW - Methamphetamine
KW - Neurochemistry
KW - Phosphorylases
KW - Proteins
KW - Neurotoxins
KW - Phosphorylation
KW - 2000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2000-16452-023&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Tripi, Paul A.
AU - Modlin, Sheryl
AU - Sorenson, W.G.
AU - Dearborn, Dorr G.
T1 - Acute pulmonary haemorrhage in an infant during induction of general anaesthesia.
JO - Paediatric Anaesthesia
JF - Paediatric Anaesthesia
Y1 - 2000/01//
VL - 10
IS - 1
M3 - Article
SP - 92
EP - 94
SN - 11555645
AB - SummaryPulmonary haemorrhage is a rare, life-threatening complication of anaesthesia. This report describes the anaesthetic management of an infant who developed laryngospasm and pulmonary haemorrhage during general anaesthesia. The infant was subsequently found to have prior exposure to a fungus, Stachybotrys chartarum, which produces mycotoxins that may have produced capillary fragility in the infant's rapidly growing lungs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric Anaesthesia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRIC anesthesia
KW - HEMORRHAGIC diseases in children
KW - LUNG diseases
KW - anaesthesia
KW - laryngospasm
KW - Pulmonary haemorrhage
KW - Stachybotrys chartarum
N1 - Accession Number: 6083165; Tripi, Paul A. 1; Modlin, Sheryl 1; Sorenson, W.G. 2; Dearborn, Dorr G. 3; Source Information: Jan2000, Vol. 10 Issue 1, p92; Subject: PEDIATRIC anesthesia; Subject: HEMORRHAGIC diseases in children; Subject: LUNG diseases; Author-Supplied Keyword: anaesthesia; Author-Supplied Keyword: laryngospasm; Author-Supplied Keyword: Pulmonary haemorrhage; Author-Supplied Keyword: Stachybotrys chartarum; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1460-9592.2000.00452.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=6083165&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107024472
T1 - Chronicles. Diethylene glycol deaths in Haiti.
AU - Junod SW
Y1 - 2000/01//Jan/Feb2000
N1 - Accession Number: 107024472. Language: English. Entry Date: 20010518. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Ethylene Glycols -- Poisoning -- In Infancy and Childhood
KW - Poisoning -- In Infancy and Childhood -- Haiti
KW - Disease Outbreaks -- Prevention and Control
KW - Kidney Failure, Acute -- Mortality -- In Infancy and Childhood
KW - Renal Insufficiency -- Chemically Induced -- In Infancy and Childhood
KW - Haiti
KW - Disease Surveillance
KW - Centers for Disease Control and Prevention (U.S.)
KW - Ethylene Glycols -- History
KW - International Relations
KW - Politics
KW - Public Health
KW - Pharmaceutical Additives -- Adverse Effects
KW - Infant
KW - Child, Preschool
SP - 78
EP - 86
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 115
IS - 1
PB - Sage Publications Inc.
SN - 0033-3549
AD - Historian, US Food and Drug Administration
U2 - PMID: 10968588.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107024472&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107110484
T1 - A policy maker's glimpse of the road ahead: telerehabilitation in the 21st century.
AU - Puskin DS
AU - Urka MA
Y1 - 2000///2000 Winter
N1 - Accession Number: 107110484. Language: English. Entry Date: 20000501. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9515174.
KW - Telemedicine -- Trends
KW - Rehabilitation -- Trends
KW - Aged
KW - United States
SP - 70
EP - 74
JO - Topics in Spinal Cord Injury Rehabilitation
JF - Topics in Spinal Cord Injury Rehabilitation
JA - TOP SPINAL CORD INJ REHABIL
VL - 5
IS - 3
CY - St. Louis, Missouri
PB - Thomas Land Publishers Incorporated
SN - 1082-0744
AD - Director, Office for the Advancement of Telehealth, Health Resources and Services Administration, US Department of Health and Human Services, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107110484&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-25203-013
AN - 2009-25203-013
AU - Rashid, M. Mushfiqur
T1 - Comparisons of rank-based methods and normal theory methods for unbalanced one-way repeated measures data.
JF - Journal of the Italian Statistical Society
JO - Journal of the Italian Statistical Society
JA - Stat Methods Appt
Y1 - 2000/01//
VL - 9
IS - 1-3
SP - 199
EP - 218
CY - Germany
PB - Springer
SN - 1618-2510
AD - Rashid, M. Mushfiqur, Division of Biometrics II, Office Biostatistics, CDER Food and Drug Administration, HFD-715, Room 9B07, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2009-25203-013. Other Journal Title: Statistical Methods and Applications. Partial author list: First Author & Affiliation: Rashid, M. Mushfiqur; Food and Drug Administration, Rockville, MD, US. Release Date: 20100920. Correction Date: 20101025. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Analysis of Covariance; Methodology; Repeated Measures. Minor Descriptor: Maximum Likelihood; Rank Order Correlation. Classification: Statistics & Mathematics (2240). Population: Human (10). Methodology: Empirical Study; Mathematical Model; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Jan, 2000.
AB - In this article, rank-based methods are developed for analyzing unbalanced one-way repeated measures data. It is assumed that errors within each subject are exchangeable random variables. R-estimates of the treatment effects are obtained by minimizing a piecewise linear function. Rank-based methods are developed for testing the equality of the treatment effects. An unbalanced data set is analyzed for illustrative purposes. The relative efficiency of the R-estimates and maximum likelihood estimates is discussed. A small scale simulation study, comparing powers and sizes of the rank-based tests and normal theory tests (e.g., Wald and F), is presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rank based methods
KW - normal theory methods
KW - unbalanced one-way repeated measures data
KW - maximum likelihood
KW - 2000
KW - Analysis of Covariance
KW - Methodology
KW - Repeated Measures
KW - Maximum Likelihood
KW - Rank Order Correlation
KW - 2000
DO - 10.1007/BF03178966
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-25203-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Castranova, Vincent
T1 - From Coal Mine Dust To Quartz: Mechanisms of Pulmonary Pathogenicity.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 7
EP - 14
SN - 08958378
AB - Exposure to coal mine dust or crystalline silica can result in the initiation and progression of interstitial lung disease. Pathogenesis is the consequence of damage to lung cells and resulting lung scarring associated with activation of fibrotic processes. This review presents the radiologic and histologic characteristics of simple and complicated coal workers’ pneumoconiosis (CWP) as well as pathological indices of acute and chronic silicosis. This presentation also reviews the results of in vitro, animal, and human investigations that elucidate mechanisms involved in the development of these pneumoconioses. Results support the involvement of four basic mechanisms in the etiology of CWP and silicosis:1. Direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring.2. Activation of oxidant production by pulmonary phagocytes, such as alveolar macrophages. When oxidant production exceeds antioxidant defenses, lipid peroxidation and protein nitrosation occur, resulting in tissue injury and consequent scarring.3. Activation of mediator release from alveolar macrophages and alveolar epithelial cells. Chemokines recruit polymorphonuclear leukocytes and macrophages from the pulmonary capillaries into the air spaces. Once within the air spaces, these leukocytes are activated by proinflammatory cytokines to produce reactive species, which increase oxidant injury and lung scarring.4. Secretion of growth factors from alveolar macrophages and alveolar epithelial cells. Release of such mediators stimulates fibroblast proliferation and induces fibrosis. In conclusion, results of in vitro and animal studies have provided the basis for proposing mechanisms that may lead to the initiation and progression of CWP and silicosis. Data obtained from exposed workers has lent support to these proposals. The mechanistic understanding obtained for the development of CWP and silicosis should be useful in elucidating the possible pathogenicity of other inhaled particles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mineral dusts
KW - Virulence (Microbiology)
KW - Air pollutants
KW - Fossil fuels
KW - Oxide minerals
N1 - Accession Number: 121039260; Castranova, Vincent 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: 2000 Supplement 3, Vol. 12, p7; Thesaurus Term: Mineral dusts; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Air pollutants; Thesaurus Term: Fossil fuels; Subject Term: Oxide minerals; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/08958378.2000.11463226
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=121039260&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vallyathan, Val
AU - Ding, Min
AU - Shi, Xianglin
AU - Castranova, Vincent
T1 - Molecular Activation of Activator Protein-1 In Silica and Asbestos-Induced Carcinogenesis.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 353
EP - 357
SN - 08958378
AB - Occupational exposures to asbestos and crystalline silica have been implicated in causing lung cancer and other pulmonary diseases in humans. Despite intensive research during the last decade on pulmonary carcinogenesis induced by these minerals, the exact molecular mechanisms involved in carcinogenesis are still unknown. Chronic inflammation and enhanced production of reactive oxygen species (ROS) generated by these particulates have been implicated in the development of tumors. In an attempt to understand the molecular basis of carcinogenesis induced by these particles, we investigated the potential activation of activator protein-1 (AP-1) by crocidolite and freshly fractured or aged crystalline silica in a JB6 P+cell line stably transfected with AP-1-luciferase reporter plasmid (in vitro) and in AP-1-luciferase reporter transgenic mice (in vivo). This transcription factor governs the expression of target genes that are involved in encoding cytokines, chemokines, growth factors, cell adhesion molecules, and acute-phase proteins that regulate inflammation, cell proliferation, and apoptosis. Results of our studies suggest that asbestos and silica activate AP-1 through generation of ROS. In in vitro studies, crocidolite asbestos caused a dose- and time-dependent AP-1 activation in JB6+ cells, which persisted for at least 72 h. In transgenic mice exposed to crocidolite asbestos, AP-1 activation increased significantly by 10-fold in lung tissue and 22-fold in bronchial tissue. This induction of AP-1 activation by crocidolite appears to be mediated through the influence of mitogen-activated protein kinase (MAPK) family members, specifically extracellular signal-regulating protein kinase, ERK 1, and ERK 2 (data not presented). Similarly, freshly fractured silica caused an 8-fold increase in AP-1 activation in JB6 P+cells and 22-fold increase in transgenic mice. The activation of AP-1 by freshly fractured silica was mediated through ERK1, ERK2, and p38 kinase. Activation of AP-1 by asbestos or silica was inhibited in both in vitro and in vivo systems by aspirin, which exhibits OH radical scavenging properties. It is proposed from these studies that asbestos and crystalline silica may promote carcinogenesis through specific mechanistic pathways stimulated by ROS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silicon compounds
KW - Carcinogenesis
KW - Genetic toxicology
KW - AP-1 transcription factor
KW - Heat resistant materials
N1 - Accession Number: 121039279; Vallyathan, Val 1; Ding, Min 1; Shi, Xianglin 1; Castranova, Vincent 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: 2000 Supplement 3, Vol. 12, p353; Thesaurus Term: Silicon compounds; Thesaurus Term: Carcinogenesis; Thesaurus Term: Genetic toxicology; Subject Term: AP-1 transcription factor; Subject Term: Heat resistant materials; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/08958378.2000.11463245
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=121039279&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kuempel, Eileen D.
AU - Tran, Chi-Lang
AU - O’Flaherty, Ellen J.
AU - Stayner, Leslie T.
AU - Smith, Randall J.
AU - Dankovic, David A.
AU - Bailer, John A.
T1 - Evaluation of Particle Clearance and Retention Kinetics in the Lungs of U.S. Coal Miners.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 397
EP - 402
SN - 08958378
AB - Rodent studies are frequently used to assess risk in humans, yet it is not known whether the overloading of lung clearance, as observed in rodents, occurs in humans, or whether overloading is related to particle-related lung diseases in humans. The objective of this study is to develop a biologically based mathematical model to describe the retention and clearance of respirable coal mine dust in the lungs of humans. A human dosimetric lung model was developed that includes alveolar, interstitial, and hilar lymph-node compartments. The model describes the particle mass transfer kinetics among these compartments and clearance via the tracheobronchi. The model was calibrated using data in U.S. coal miners, including individual working lifetime exposure histories and lung and lymph-node particle burdens. The model fit to the human data was evaluated using a least-squared error criterion. The end-of-life lung dust burdens of all coal miners in this study were substantially greater than expected from a simple, linear first-order model with effective clearance, yet their lung and lymph-node dust burdens were lower than expected from the rodent-based overload model, particularly at higher exposures. The best fitting model included a predominant first-order interstitial compartment, in which the particles are essentially sequestered (with very slow clearance to the lymph nodes), and a first-order alveolar clearance compartment with either no dose-dependent decline (overloading) or much less than expected from the rodent studies. These findings are consistent with the findings from magnetopneumography studies of clearance in retired miners and from studies of particle retention patterns in rodents and primates. This human dosimetric lung model is useful for evaluating the kinetic differences of particle retention in humans and rodents, and for evaluating the lung closes in humans given different exposure scenarios. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Coal dust
KW - Coal miners -- United States
KW - Coal miners
KW - Lung diseases -- Patients
KW - Lymph nodes
N1 - Accession Number: 121039285; Kuempel, Eileen D. 1; Tran, Chi-Lang 2; O’Flaherty, Ellen J. 3; Stayner, Leslie T. 1; Smith, Randall J. 1; Dankovic, David A. 1; Bailer, John A. 1,4; Affiliations: 1: National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, Ohio, USA; 2: Institute for Occupational Medicine, Edinburgh, Scotland, United Kingdom; 3: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA; 4: Miami University, Oxford, Ohio, USA; Issue Info: 2000 Supplement 3, Vol. 12, p397; Thesaurus Term: DISEASES; Thesaurus Term: Coal dust; Subject Term: Coal miners -- United States; Subject Term: Coal miners; Subject Term: Lung diseases -- Patients; Subject Term: Lymph nodes; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/08958378.2000.11463251
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Goering, Peter L.
AU - Fisher, Benjamin R.
AU - Noren, Bradley T.
AU - Papaconstantinou, Andriana
AU - Rojko, Jennifer L.
AU - Marler, Ronald J.
T1 - Mercury induces regional and cell-specific stress protein expression in rat kidney.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/02//
VL - 53
IS - 2
M3 - Article
SP - 447
EP - 457
PB - Oxford University Press / USA
SN - 10966080
AB - Cells respond to physiologic stress by enhancing the expression of specific stress proteins. Heat-shock proteins (hsps) and glucose-regulated proteins (grps) are members of a large superfamily of proteins collectively referred to as stress proteins. This particular stress-protein response has evolved as a cellular strategy to protect, repair, and chaperone other essential cellular proteins. The objective of this study was to evaluate the differential expression of four hsps in the renal cortex and medulla during experimental nephrotoxic injury using HgCl2. Male Sprague-Dawley rats received single injections of HgCl2 (0.25, 0.5, or 1 mg Hg/kg, iv). At 4, 8, 16, or 24 h after exposure, kidneys were removed and processed for histopathologic, immunoblot, and immunohistochemical analyses. Nephrosis was characterized as minimal or mild (cytoplasmic condensation, tubular epithelial degeneration, single cell necrosis) at the lower exposures, and progressed to moderate or severe (nuclear pyknosis, necrotic foci, sloughing of the epithelial casts into tubular lumens) at the highest exposures. Western blots of renal proteins were probed with monoclonal antibodies specific for hsps. In whole kidney, Hg(II) induced a time- and dose-related accumulation of hsp72 and grp94. Accumulation of hsp72 was predominantly localized in the cortex and not medulla, while grp94 accumulated primarily in the medulla but not cortex. The high, constitutive expression of hsp73 did not change as a result of Hg(II) exposure, and it was equally localized in cortex and medulla. Hsp90 was not detected in kidneys of control or Hg-treated rats. Since hsp72 has been shown involved in cellular repair and recovery, and since Hg(II) damage occurs primarily in cortex, we investigated the cell-specific expression of this hsp. Hsp72 accumulated primarily in undamaged proximal convoluted-tubule epithelia. These results demonstrate that expression of specific stress proteins in rat kidney exhibits regional heterogeneity in response to Hg(II) exposure, and a positive correlation exists between accumulation of some stress proteins and acute renal cell injury. While the role of accumulation of hsps and other stress proteins in vivo prior to or concurrent with nephrotoxicity remains to be completely understood, these stress proteins may be part of a cellular defense response to nephrotoxicants. Conversely, renal tubular epithelial cells that do not or are unable to express stress proteins, such as hsp72, may be more susceptible to nephrotoxicity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mercury
KW - Heat shock proteins
KW - Glucose
KW - Kidney diseases
KW - Monoclonal antibodies
KW - acute renal injury
KW - glucose-regulated proteins
KW - grp94
KW - heat-shock proteins
KW - hsp72
KW - immunohistochemistry
KW - immunohistochemistry.
KW - kidney
KW - mercury
KW - stress proteins
N1 - Accession Number: 44405903; Goering, Peter L. 1; Email Address: plg@cdrh.fda.gov; Fisher, Benjamin R. 1; Noren, Bradley T. 2; Papaconstantinou, Andriana 1; Rojko, Jennifer L. 2; Marler, Ronald J. 3; Affiliations: 1: Health Sciences Branch, Division of Life Sciences, Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20857; 2: Pathology Associates International, Frederick, Maryland 21701; 3: Covance Laboratories, Vienna, Virginia 22182; Issue Info: Feb2000, Vol. 53 Issue 2, p447; Thesaurus Term: Mercury; Subject Term: Heat shock proteins; Subject Term: Glucose; Subject Term: Kidney diseases; Subject Term: Monoclonal antibodies; Author-Supplied Keyword: acute renal injury; Author-Supplied Keyword: glucose-regulated proteins; Author-Supplied Keyword: grp94; Author-Supplied Keyword: heat-shock proteins; Author-Supplied Keyword: hsp72; Author-Supplied Keyword: immunohistochemistry; Author-Supplied Keyword: immunohistochemistry.; Author-Supplied Keyword: kidney; Author-Supplied Keyword: mercury; Author-Supplied Keyword: stress proteins; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 11p; Illustrations: 6 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2007-17617-001
AN - 2007-17617-001
AU - Wasem, Cathy
AU - Puskin, Dena
T1 - High-tech with the human touch: Using telehealth to reach America's children.
JF - Professional Psychology: Research and Practice
JO - Professional Psychology: Research and Practice
JA - Prof Psychol Res Pr
Y1 - 2000/02//
VL - 31
IS - 1
SP - 3
EP - 4
CY - US
PB - American Psychological Association
SN - 0735-7028
SN - 1939-1323
N1 - Accession Number: 2007-17617-001. Other Journal Title: Professional Psychology. Partial author list: First Author & Affiliation: Wasem, Cathy; Telemedicine/Telehealth Programs, Health Resources and Services Administration, U.S. Department of Health and Human Services, US. Release Date: 20071112. Correction Date: 20160915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Telemedicine. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Page Count: 2. Issue Publication Date: Feb, 2000. Copyright Statement: Public Domain
AB - [Correction Notice: An erratum for this article was reported in Vol 31(2) of Professional Psychology: Research and Practice (see record [rid]2007-17403-001[/rid]). On page 4, the last sentence of text incorrectly reads, 'For additional telehealth project, policy, legal, and funding information, visit OAT's web site at http://www.telehealth.hrsa.gov.' The correct web site address is http://telehealth.hrsa.gov.] In the past decade, we have seen new telecommunication and information technologies used to provide health services, health professional and consumer education, and public health and administrative services. The application of these tools to health care, commonly referred to as telehealth, provides an unprecedented opportunity, as we embark on a new millennium, to take services to those in need-to 'carry the water to the desert.' Telehealth provides both a means to increase access, and to reengineer the processes of care, enhancing the equality and effectiveness of health services. This article illustrates how telehealth has helped children and youth in various health care settings. Many of these projects have been initiated with federal funds from OAT or other federal agencies. Some of the projects use technologies that require special phone lines and expensive equipment ranging from $15,000 to $50,000; others run over regular phone lines and use equipment costing between $500 to $1,000. Psychologists are involved in many of these projects as initiators of services, as members of multidisciplinary teams, and as researchers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - telehealth
KW - health care settings
KW - children and youth
KW - 2000
KW - Health Care Services
KW - Telemedicine
KW - 2000
DO - 10.1037/0735-7028.31.1.3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17617-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2000-13299-004
AN - 2000-13299-004
AU - Zhuang, Ziqing
AU - Stobbe, Terrence J.
AU - Collins, James W.
AU - Hsiao, Hongwei
AU - Hobbs, Gerald R.
T1 - Psychophysical assessment of assistive devices for transferring patients/residents.
JF - Applied Ergonomics
JO - Applied Ergonomics
JA - Appl Ergon
Y1 - 2000/02//
VL - 31
IS - 1
SP - 35
EP - 44
CY - Netherlands
PB - Elsevier Science
SN - 0003-6870
N1 - Accession Number: 2000-13299-004. PMID: 10709750 Partial author list: First Author & Affiliation: Zhuang, Ziqing; US Dept of Health & Human Services, Public Health Service, Ctr for Disease Control & Prevention, NIOSH, Morgantown, WV, US. Release Date: 20000301. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Nursing Homes; Physiological Stress; Psychological Stress; Technology. Minor Descriptor: Nonprofessional Personnel. Classification: Engineering & Environmental Psychology (4000); Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 10. Issue Publication Date: Feb, 2000.
AB - Investigated the effects of resident-transferring methods on the psychophysical stress to nursing assistants performing the transferring task and identified transfer methods that could reduce this psychophysical stress. Nine nursing assistants and 2 elderly residents participated. A psychophysical stress assessment was performed on 9 battery-powered lifts, a sliding board, a walking belt, and a baseline manual method for transferring nursing home patients/residents from a bed to a chair. Results indicated that the psychophysical stresses on nursing assistants were significantly lower when performing resident transfers with some of the assistive devices than when performing transfers with the baseline manual transfer method. The nursing assistants generally preferred the basket-sling lift and stand-up lift to other methods. The residents' comfort and security ratings indicated the comfort and security with most of the assistive devices were greater than or equal to the baseline manual method. Most of the comments of the nursing assistants and residents on the assistive devices were favorable. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - basket-sling vs stand-up vs overhead lift vs walking belt vs sliding board vs baseline manual resident-transferring methods
KW - psychophysical stress
KW - nursing home assistants & volunteers
KW - 2000
KW - Human Factors Engineering
KW - Nursing Homes
KW - Physiological Stress
KW - Psychological Stress
KW - Technology
KW - Nonprofessional Personnel
KW - 2000
DO - 10.1016/S0003-6870(99)00023-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2000-13299-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chin, Marshall H.
AU - Auerbach, Steven B.
AU - Cook, Sandy
AU - Harrison, James F.
AU - Koppert, Julie
AU - Lei Jin
AU - Thiel, Fay
AU - Karrison, Theodore G.
AU - Harrand, Anita G.
AU - Schaefer, Cynthia T.
AU - Takashima, Herbert T.
AU - Egbert, Nancy
AU - Sin-Ching Chiu
AU - McNabb, Wylie L.
T1 - Quality of Diabetes Care in Community Health Centers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/03//
VL - 90
IS - 3
M3 - Article
SP - 431
EP - 434
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study assessed the quality of diabetes care in community health centers. Methods. In 55 midwestern community health centers, we reviewed the charts of 2865 diabetic adults for American Diabetes Association measures of quality. Results. On average, 70% of the patients in each community health center had measurements of glycosylated hemoglobin, 26% had dilated eye examinations, 66% had diet intervention, and 51% received foot care. The average glycosylated hemoglobin value per community health center was 8.6%. Practice guidelines were independently associated with higher quality of care. Conclusions. Rates of adherence to process measures of quality were relatively low among community health centers, compared with the targets established by the American Diabetes Association. (Am d Public Health. 2000;90:431-434) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical care -- Quality control
KW - Diabetes
KW - Medical centers
KW - Community health services
KW - American Diabetes Association
N1 - Accession Number: 2856541; Chin, Marshall H. 1; Email Address: mchin@medicine.bsd.uchicago.edu; Auerbach, Steven B. 2; Cook, Sandy 1; Harrison, James F. 3; Koppert, Julie 4; Lei Jin 1; Thiel, Fay 4; Karrison, Theodore G. 1; Harrand, Anita G. 5; Schaefer, Cynthia T. 6; Takashima, Herbert T. 2; Egbert, Nancy 2; Sin-Ching Chiu 7; McNabb, Wylie L. 1; Affiliations: 1: Departments of Medicine and Health Studies, Diabetes Research and Training Center, University of Chicago, Ill.; 2: Health Resources and Services Administration Field Offices, New York, NY; Kansas City, Mo; and Chicago, Ill.; 3: North Woods Community Health Center, Minong, Wis.; 4: MidWest Clinicians' Network, Inc, Kenton, Ohio, and Okemos, Mich.; 5: Hamilton Family Medical Center, Flint, Mich.; 6: ECHO Health Center, Evansville, Ind.; 7: Family Medical Center, Temperance, Mich.; Issue Info: Mar2000, Vol. 90 Issue 3, p431; Subject Term: Medical care -- Quality control; Subject Term: Diabetes; Subject Term: Medical centers; Subject Term: Community health services ; Company/Entity: American Diabetes Association DUNS Number: 784510570; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article; Full Text Word Count: 2814
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107111737
T1 - Assessment of the infraspinatus spinal stretch reflex in the normal, athletic, and multidirectionally unstable shoulder.
AU - Auge WK II
AU - Morrison DS
Y1 - 2000/03//Mar/Apr2000
N1 - Accession Number: 107111737. Language: English. Entry Date: 20000601. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7609541.
KW - Reflex, Stretch
KW - Glenohumeral Joint
KW - Joint Instability
KW - Neuromuscular Control
KW - Female
KW - Comparative Studies
KW - Dynamometry
KW - Electric Stimulation
KW - Torque
KW - Rotation
KW - Electromyography
KW - Motor Neurons
KW - Analysis of Variance
KW - Descriptive Statistics
KW - Adolescence
KW - Adult
KW - Reproducibility of Results
KW - Validity
KW - Human
SP - 206
EP - 213
JO - American Journal of Sports Medicine
JF - American Journal of Sports Medicine
JA - AM J SPORTS MED
VL - 28
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - To examine neural aspects of motor control in the glenohumeral joint, this study evaluates utilization of an innate spinal segmental pathway, the spinal stretch reflex, as an investigational tool that reflects neural circuitry. The purpose of this study was to determine if this reflex could be evoked from the infraspinatus muscle, if the testing apparatus and protocol for elicitation were reliable, and if the reflex response varies between groups of subjects and therefore could be useful clinically. These reflex characteristics were evaluated in the infraspinatus muscle, since rotator cuff muscle activity in subjects with glenohumeral instability exhibits differences in electromyographic activity and coordination patterns, implicating its role in dynamic stability. Normal shoulders were compared with athletic shoulders and shoulders with multidirectional instability. The spinal stretch reflex was elicited in a controlled and reliable manner. Shoulders with multidirectional instability exhibited a more-prominent spinal stretch reflex response than normal shoulders, whereas athletic shoulders exhibited a more-quiescent spinal stretch reflex response. As the spinal stretch reflex probably plays a role in motor control, variation in this reflex profile may reflect some differences in development that contribute to the variable expression of dynamic glenohumeral stability. This study suggests that the spinal stretch reflex profile may be a useful clinical tool to assist in discriminating between the normal and pathologic state. This information may also be useful in the evaluation of new treatment approaches exploiting spinal cord plasticity and spinal stretch reflex mutability through neuromuscular training.
SN - 0363-5465
AD - Public Health Service, United States Dept of Health and Human Services, Santa Fe, New Mexico
U2 - PMID: 10750997.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moody, J. D.
AU - Heinze, T. M.
AU - Hansen Jr., E. B.
AU - Cerniglia, C. E.
T1 - Metabolism of the ethanolamine-type antihistamine diphenhydramine (Benadryl)TM by the fungus Cunninghamella elegans.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2000/03//
VL - 53
IS - 3
M3 - Article
SP - 310
EP - 315
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Two strains of the filamentous fungus Cunninghamella elegans (ATCC 9245 and ATCC 36112) were grown in Sabouraud dextrose broth and screened for the ability to metabolize the ethanolamine-type antihistamine diphenhydramine. Based on the amount of parent drug recovered after 7 days incubation, both C. elegans strains metabolized approximately 74% of the diphenhydramine, 58% of this being identified as organic extractable metabolites. The organic extractable metabolites were isolated by reversed-phase high-performance liquid chromatography and identified by analyzing their mass and nuclear magnetic resonance spectra. Desorption chemical ionization mass spectrometry (DCIMS) with deuterated ammonia was used to differentiate possible isobaric diphenhydramine metabolites and to probe the mechanisms of ion formation under ammonia DCIMS conditions. C. elegans transformed diphenhydramine by demethylation, oxidation, and N-acetylation. The major metabolites observed were diphenhydramine-N-oxide (3%), N-desmethyldiphenhydramine (30%), N-acetyldidesmethyldiphenhydramine (13%), and N-acetyl-N-desmethyldiphenhydramine (12%). These compounds are known mammalian metabolites of diphenhydramine and may be useful for further toxicological studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungi
KW - Amines
KW - Metabolites
KW - Ammonia
KW - Mammals
KW - Antihistamines
KW - Caenorhabditis elegans
N1 - Accession Number: 15680477; Moody, J. D. 1; Heinze, T. M. 2; Hansen Jr., E. B. 2; Cerniglia, C. E. 1; Email Address: CCerniglia@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Ar 72079-9502, USA; 2: Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA; Issue Info: Mar2000, Vol. 53 Issue 3, p310; Thesaurus Term: Fungi; Thesaurus Term: Amines; Thesaurus Term: Metabolites; Thesaurus Term: Ammonia; Thesaurus Term: Mammals; Subject Term: Antihistamines; Subject Term: Caenorhabditis elegans; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nigg, H. N.
AU - Elliott, P. M.
AU - Brock, J. W.
AU - Sampson, E. J.
AU - Szanyi, D. N.
AU - Weems, K.
AU - Chandler, W.
AU - Reynolds, R.
AU - Walker, T.
T1 - Organochlorine Compounds in Florida Feral Pigs (Sus scofa).
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 2000/03//
VL - 64
IS - 3
M3 - Article
SP - 347
EP - 353
PB - Springer Science & Business Media B.V.
SN - 00074861
AB - This article presents information related to presence of organochlorine compounds in Florida Feral pigs. Before traps were installed, feral pigs were habituated to whole corn by stringing the bait down a selected woods trail over a nine mile transect. In a simultaneous operation, pigs were bled with an 18 gauge needle and 15 ml plastic syringe from the jugular vein, inoculated with RB-5 1 vaccine, tagged on one ear, notched on the other ear, and ticks were collected. About 50% of male and female swine had hexachlorobenzene in their blood plasma. This compound is used as a fungicide in grain and appears in the environment as a manufacturing byproduct.
KW - Feral swine
KW - Hexachlorobenzene
KW - Fungicides
KW - Organochlorine compounds
KW - Jugular vein
KW - Serum
N1 - Accession Number: 15247279; Nigg, H. N. 1; Elliott, P. M. 2; Brock, J. W. 3; Sampson, E. J. 3; Szanyi, D. N. 4; Weems, K. 4; Chandler, W. 4; Reynolds, R. 4; Walker, T. 4; Affiliations: 1: University of Florida, Institute of Food and Agricultural Sciences, Citrus Research and Education Center, 700 Experiment Station Road, Lake Alfred, FL 33850, USA; 2: Southwest Florida Water Management District, 170 Century Boulevard, Bartow, FL 33830-7700, USA; 3: Division of Environmental Health Laboratory Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30341-3727, USA; 4: USDA, APHIS, Veterinary Services, 7022 NW 10th Place, Gainesville, FL 32605, USA; Issue Info: Mar2000, Vol. 64 Issue 3, p347; Thesaurus Term: Feral swine; Thesaurus Term: Hexachlorobenzene; Thesaurus Term: Fungicides; Subject Term: Organochlorine compounds; Subject Term: Jugular vein; Subject Term: Serum; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10. 1007/s001280000006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106949253
T1 - A practical guide for the management of geriatric incontinence.
AU - Attico NB
AU - Woo JJ
AU - Dekker AH
Y1 - 2000/03//2000 Mar
N1 - Accession Number: 106949253. Language: English. Entry Date: 20020816. Revision Date: 20150711. Publication Type: Journal Article; algorithm; consumer/patient teaching materials; exam questions; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8002229.
KW - Urinary Incontinence -- Prevention and Control -- In Old Age
KW - Urinary Incontinence -- Etiology -- In Old Age
KW - Urinary Incontinence -- Drug Therapy -- In Old Age
KW - Urinary Incontinence -- Diagnosis -- In Old Age
KW - Patient Education
KW - Aged
KW - Aged, 80 and Over
SP - 22
EP - 38
JO - Family Practice Recertification
JF - Family Practice Recertification
JA - FAM PRACT RECERTIF
VL - 22
IS - 3
CY - Plainsboro, New Jersey
PB - Intellisphere, LLC
AB - Urinary incontinence is a significant health problem for many older adults. It predisposes them to medical problems such as rashes, skin infections, pressure sores, and urinary tract infections. Psychological complications include lowered self-esteem, isolation, a reduced quality of life, and depression. Most affected persons do not seek help, primarily because of embarrassment or the mistaken belief that the condition cannot be treated. Physicians must ask older patients direct questions about incontinence and let them know that it can be successfully treated. Transient incontinence often resolves once the underlying condition is treated. Established incontinence can be managed with behavioral therapy, pharmacotherapy, or surgery.
SN - 0163-6642
AD - Director, Maternal Child Health Program, Phoenix Area Indian Health Service, Phoenix, AZ
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thurston, Norman K.
AU - Libby, Anne M.
T1 - Taxes and Physicians' Use of Ancillary Health Labor.
JO - Journal of Human Resources
JF - Journal of Human Resources
Y1 - 2000///Spring2000
VL - 35
IS - 2
M3 - Article
SP - 259
EP - 278
PB - University of Wisconsin Press
SN - 0022166X
AB - Recent papers have examined the effect of taxes on the labor supply of high income individuals and on the demand for employee labor; entrepreneurs' decisions to hire workers are seen to be quite sensitive to changes in marginal tax rates. However, little is known about the applicability of these findings to physician services. The authors posit a straightforward model of physician utility-maximization, where physician-employers jointly choose own work effort and other labor inputs. There is no theoretical prediction about the sign or magnitude of the cross-price effects of changes in physicians' tax rates on their choice of ancillary labor inputs. The authors estimate the impact of taxation of physician income on both the extensive and intensive margins using state-level variation in marginal income tax rates to identify the effects. They also examine the sensitivity of total and per worker compensation to variation in marginal tax rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Human Resources is the property of University of Wisconsin Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAXATION
KW - LABOR supply
KW - LABOR market
KW - SUPPLY & demand
KW - EMPLOYMENT (Economic theory)
KW - LABOR economics
KW - TAX rates & tables
KW - EMPLOYEE selection
KW - PERSONNEL management
KW - EMPLOYEE screening
N1 - Accession Number: 3277753; Thurston, Norman K. 1; Email Address: nkt@byu.edu; Libby, Anne M. 2; Affiliations: 1: Brigham Young University, Provo, Utah; 2: Center for Mental Health Services Research, University of California, Berkeley; Issue Info: Spring2000, Vol. 35 Issue 2, p259; Thesaurus Term: TAXATION; Thesaurus Term: LABOR supply; Thesaurus Term: LABOR market; Thesaurus Term: SUPPLY & demand; Thesaurus Term: EMPLOYMENT (Economic theory); Thesaurus Term: LABOR economics; Thesaurus Term: TAX rates & tables; Thesaurus Term: EMPLOYEE selection; Thesaurus Term: PERSONNEL management; Thesaurus Term: EMPLOYEE screening; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 921130 Public Finance Activities; Number of Pages: 20p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Schwartz, Rachel M.
AU - Muri, Janet H.
AU - Overpeck, Mary D.
AU - Pezzullo, John C.
AU - Kogan, Michael D.
T1 - Use of High-Technology Care Among Women with High-Risk Pregnancies in the United States.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2000/03//
VL - 4
IS - 1
M3 - Article
SP - 7
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objective: Infant mortality has been reduced dramatically with the development of perinatal regionalized high-technology care. Our objective was to assess use of high technology care among women with high-risk pregnancies in the urban and rural United States. Methods: The 1988 National Maternal and Infant Health Survey was linked to the 1988 American Hospital Association survey of all obstetrical hospitals. Hospitals were classified into five levels of care based on services and staffing. Women were classified as having high-risk pregnancies using two definitions: (1) gestational age <34 weeks and birthweight <1500 g (High Risk I) and (2) the first definition or an antenatal high-risk medical diagnoses (High Risk II). Analyses assessed the proportion of high-risk women delivering in appropriate locations in the rural and urban United States and explored how personal characteristics, insurance status, and use and source of prenatal care influenced where high-risk women delivered. Results: 71.2% of High Risk I and 55.9% of High Risk II women delivered in a high-technology facility (Level IIA or III). Fifty percent of HRI rural women delivered in tertiary high-technology hospitals and 39% of HRII rural women delivered in a high-technology hospital. High-risk urban women were two to three times more likely to deliver in a high-technology facility compared to their rural counterparts. The multivariate analysis showed that Black high-risk women were more likely to deliver in a high-technology setting and that receipt of prenatal care in a private setting lowered the odds of delivering in a high-technology setting when other factors were controlled. Conclusions: In an era where regionalized perinatal care was not threatened by managed care, a large proportion of high-risk women received care in less than optimal settings. Rural high-risk women delivered in high-technology hospitals less often than their urban counterparts. The multivariate analyses implied that the potential barriers to care may be more important among those considered more socially advantaged, who may be more at the mercy of managed care. The current reimbursement environment, which discourages referral to specialists and high-technology care, could result in less access today. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERNAL health services
KW - LOW birth weight
KW - PREMATURE labor
KW - INFANT mortality
KW - MEDICAL care -- United States
KW - UNITED States
KW - access
KW - high risk care
KW - levels of care
KW - low birth weight
KW - perinatal regionalization
KW - prematurely
N1 - Accession Number: 11307818; Schwartz, Rachel M. 1; Email Address: rmschwartz@aol.com; Muri, Janet H. 1; Overpeck, Mary D. 2; Pezzullo, John C. 3; Kogan, Michael D. 4; Source Information: Mar2000, Vol. 4 Issue 1, p7; Subject: MATERNAL health services; Subject: LOW birth weight; Subject: PREMATURE labor; Subject: INFANT mortality; Subject: MEDICAL care -- United States; Geographic Terms: UNITED States; Author-Supplied Keyword: access; Author-Supplied Keyword: high risk care; Author-Supplied Keyword: levels of care; Author-Supplied Keyword: low birth weight; Author-Supplied Keyword: perinatal regionalization; Author-Supplied Keyword: prematurely; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Duffy, Sarah Q.
AU - Ruseski, Jane E.
AU - Cavanaugh, Sean
AU - Duffy, S Q
AU - Ruseski, J E
AU - Cavanaugh, S
T1 - Graduate medical education costs in nonacademic health center teaching hospitals: evidence from Maryland.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03//
VL - 57
IS - 1
M3 - journal article
SP - 3
EP - 23
SN - 10775587
AB - As managed care has grown, much concern has been expressed about the potential plight of the nation's 125 academic health centers (AHCs). Less concern has focused on non-AHC teaching hospitals, although most studies of graduate medical education (GME) costs include these hospitals in their estimates. While most studies have found that costs increase positively with various measures of "teaching intensity," some have concluded that hospitals with smaller programs have costs that are the same or less than comparable nonteaching hospitals. However, few studies have tested whether AHCs' cost structures are sufficiently similar to those of other hospitals to reliably include them in the same estimation. This article tests that assumption for Maryland hospitals, finds it violated, and presents results for non-AHC teaching hospitals. The results reveal that, at least in Maryland, even small teaching programs add to hospital costs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEACHING hospitals
KW - MEDICAL centers
KW - MEDICINE -- Study & teaching (Graduate)
KW - COST
KW - MARYLAND
KW - UNITED States
N1 - Accession Number: 2861098; Duffy, Sarah Q.; Ruseski, Jane E.; Cavanaugh, Sean; Duffy, S Q 1; Ruseski, J E; Cavanaugh, S; Source Information: Mar2000, Vol. 57 Issue 1, p3; Subject: TEACHING hospitals; Subject: MEDICAL centers; Subject: MEDICINE -- Study & teaching (Graduate); Subject: COST; Geographic Terms: MARYLAND; UNITED States; Number of Pages: 21p; Document Type: journal article; Full Text Word Count: 9595
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107102024
T1 - Device safety. Pacing your patients.
AU - Dwyer D
Y1 - 2000/03//
N1 - Accession Number: 107102024. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Failure
KW - Cardiac Pacing, Artificial
KW - Pacemaker, Artificial -- Adverse Effects
SP - 82
EP - 82
JO - Nursing
JF - Nursing
JA - NURSING
VL - 30
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 11000828.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107102024&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107010057
T1 - FDA requirements for mandatory pediatric trials.
AU - Robie-Suh KM
Y1 - 2000/03//
N1 - Accession Number: 107010057. Language: English. Entry Date: 20010330. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 100939532.
KW - Drug Labeling -- Legislation and Jurisprudence -- United States
KW - Drugs -- Therapeutic Use -- In Infancy and Childhood
KW - Clinical Trials
KW - Education, Continuing (Credit)
KW - United States
KW - Child
KW - United States Food and Drug Administration
KW - Government Regulations
KW - Drugs, Off-Label -- Therapeutic Use -- In Infancy and Childhood
KW - Legislation, Drug -- United States
SP - 37
EP - 68
JO - Research Practitioner
JF - Research Practitioner
JA - RES PRACT
VL - 1
IS - 2
CY - Boston, Massachusetts
PB - CenterWatch
AB - The unique requirements of children in regard to the drug development process have been neglected over the years. Pediatricians have had to extrapolate information derived from adults when prescribing the vast majority of medications to their patients. Several regulatory actions in the 1990s attempt to refocus attention on this problem and to encourage pharmaceutical manufacturers to develop their drugs with specific pediatric labeling indications as a goal. This paper will review these regulatory advances and the rationale for their implementation.
SN - 1528-0330
AD - Medical Officer, Division of Gastrointestinal & Coagulation Drug Products, Center for Drug Evaluation & Research, Food and Drug Administration
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107010057&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107010059
T1 - Qualifications and procedures for pediatric exclusivity.
AU - Lumpkin M
Y1 - 2000/03//
N1 - Accession Number: 107010059. Language: English. Entry Date: 20010330. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 100939532.
KW - United States Food and Drug Administration -- Legislation and Jurisprudence -- United States
KW - Drug Labeling
KW - Drugs -- Therapeutic Use -- In Infancy and Childhood
KW - Education, Continuing (Credit)
KW - Child
KW - Government Regulations
KW - United States
KW - Pharmaceutical Companies
KW - Clinical Trials -- In Infancy and Childhood
SP - 41
EP - 68
JO - Research Practitioner
JF - Research Practitioner
JA - RES PRACT
VL - 1
IS - 2
CY - Boston, Massachusetts
PB - CenterWatch
AB - The Food and Drug Administration Modernization Act (FDAMA) of 1997 and the Pediatric Final Rule of 1998 have placed certain incentives and requirements on drug manufacturers to attend to issues of use of their drugs in children. This will require, among other things, studies in children. In return, exclusivity rights may be granted to a company for effectively obtaining pediatric specific labeling indications. The details of and rationale far these exclusivity rights are the focus of this paper.
SN - 1528-0330
AD - Deputy Center Director for Review Management, Center for Drug Evaluation and Research, Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106892681
T1 - Access to oral health care services remains challenging.
AU - Anderson JR
Y1 - 2000///2000 Spring
N1 - Accession Number: 106892681. Language: English. Entry Date: 20020118. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA.
KW - Dental Care -- Trends -- United States
KW - Health Services Accessibility -- Trends -- United States
KW - United States
KW - Rural Health Services -- Trends
SP - 2
EP - 3
JO - Rural Clinician Quarterly
JF - Rural Clinician Quarterly
JA - RURAL CLINICIAN Q
VL - 10
IS - 2
CY - Buffalo, New York
PB - National Rural Health Association
AD - Chief Dental Officer, Division of Community and Migrant Health, Bureau of Primary Health Care, Health Resources and Services Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Blair, Robert M.
AU - Hong Fang
AU - Branham, William S.
AU - Hass, Bruce S.
AU - Dial, Stacey L.
AU - Moland, Carrie L.
AU - Weida Tong
AU - Leming Shi
AU - Perkins, Roger
AU - Sheehan, Daniel M.
T1 - The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/03//
VL - 54
IS - 1
M3 - Article
SP - 138
EP - 153
PB - Oxford University Press / USA
SN - 10966080
AB - We have utilized a validated (standardized) estrogen receptor (ER) competitive-binding assay to determine the ER affinity for a large, structurally diverse group of chemicals. Uteri from ovariectomized Sprague-Dawley rats were the ER source for the competitive-binding assay. Initially, test chemicals were screened at high concentrations to determine whether a chemical competed with [3H]-estradiol for the ER. Test chemicals that exhibited affinity for the ER in the first tier were subsequently assayed using a wide range of concentrations to characterize the binding curve and to determine each chemical's IC50 and relative binding affinity (RBA) values. Overall, we assayed 188 chemicals, covering a 1 × 106-fold range of RBAs from several different chemical or use categories, including steroidal estrogens, synthetic estrogens, antiestrogens, other miscellaneous steroids, alkylphenols, diphenyl derivatives, organochlorines, pesticides, alkylhydroxybenzoate preservatives (parabens), phthalates, benzophenone compounds, and a number of other miscellaneous chemicals. Of the 188 chemicals tested, 100 bound to the ER while 88 were non-binders. Included in the 100 chemicals that bound to the ER were 4-benzyloxyphenol, 2,4-dihydroxybenzophenone, and 2,2′-methylenebis(4-chlorophenol), compounds that have not been shown previously to bind the ER. It was also evident that certain structural features, such as an overall ring structure, were important for ER binding. The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Phthalate esters
KW - Pesticides
KW - Estrogen receptors
KW - Ovariectomy
KW - Protein binding
KW - alkylphenols
KW - antiestrogens
KW - estrogen receptor competitive-binding assay
KW - estrogens
KW - organochlorines
KW - parabens
KW - pesticides
KW - phthalates
KW - relative binding affinity
N1 - Accession Number: 44405934; Blair, Robert M. 1; Email Address: rblair@nctr.fda.gov; Hong Fang 1; Branham, William S. 1; Hass, Bruce S. 1; Dial, Stacey L. 1; Moland, Carrie L. 1; Weida Tong 2; Leming Shi 2; Perkins, Roger 2; Sheehan, Daniel M. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; 2: R.O.W. Sciences, Jefferson, Arkansas 72079; Issue Info: Mar2000, Vol. 54 Issue 1, p138; Thesaurus Term: Phthalate esters; Thesaurus Term: Pesticides; Subject Term: Estrogen receptors; Subject Term: Ovariectomy; Subject Term: Protein binding; Author-Supplied Keyword: alkylphenols; Author-Supplied Keyword: antiestrogens; Author-Supplied Keyword: estrogen receptor competitive-binding assay; Author-Supplied Keyword: estrogens; Author-Supplied Keyword: organochlorines; Author-Supplied Keyword: parabens; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: phthalates; Author-Supplied Keyword: relative binding affinity; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 16p; Illustrations: 13 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107128390
T1 - Keynote address...proceedings from the first annual meeting held in Washington, DC in September 1999 on 'Women and Medicare'
AU - Jones WK
Y1 - 2000/03//2000 Mar-Apr
N1 - Accession Number: 107128390. Language: English. Entry Date: 20000901. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Health Status
KW - Women's Health
KW - United States Department of Health and Human Services -- Administration
KW - Female
KW - Aged
KW - United States
KW - Organizational Objectives
KW - Information Services
KW - Health Promotion
SP - 86
EP - 89
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 10
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Deputy Assistant Secretary for Health, US Department of Health and Human Services
U2 - PMID: 10777289.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Monheit, Alan C.
AU - Vistnes, Jessica Primoff
T1 - Race/Ethnicity and Health Insurance Status: 1987 and 1996.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 11
EP - 35
SN - 10775587
AB - Health insurance confers important private and social benefits. Disparities in coverage among the population remain an important public policy issue. The authors focus on the health insurance status of white, black, and Hispanic Americans in both 1987 and 1996 and identify gaps in minority health care coverage relative to white Americans. They also investigate the access of workers in these groups to employment-based health insurance. Identified are factors underlying changes in the insurance status of workers during the past decade in terms of changes in population characteristics and structural shifts underlying the demand for and supply of health insurance. The authors find that while coverage has declined for workers in most racial/ethnic groups, the experience of Hispanic males appears to be unique in that changes in their characteristics as well as structural shifts account for their decline in employment-related coverage. Structural shifts dominated the changes in coverage rates for other groups. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926031; Monheit, Alan C. 1; Vistnes, Jessica Primoff 1; Source Information: Supplement 1, Vol. 57 Issue S1, p11; Number of Pages: 25p; Document Type: Article; Full Text Word Count: 9713
L3 - 10.1177/107755870005700102
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Weinick, Robin M.
AU - Zuvekas, Samuel H.
AU - Cohen, Joel W.
T1 - Racial and Ethnic Differences in Access to and Use of Health Care Services, 1977 to 1996.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 36
EP - 54
SN - 10775587
AB - This article focuses on racial and ethnic disparities in health care, describing both absolute differences and relative changes in access to care and the use of health services among whites, blacks, and Hispanics over the past two decades. Using data from a series of three nationally representative medical expenditure surveys, the authors present descriptive statistics on disparities in access and use between minorities and whites over time. They also use multivariate analyses to isolate the extent to which health insurance and income explain those disparities. The authors find that disparities increased between 1977 and 1996, particularly for Hispanic Americans. Results also show that approximately one half to three quarters of the disparities observed in 1996 would remain even if racial and ethnic disparities in income and health insurance coverage were eliminated. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926032; Weinick, Robin M. 1; Zuvekas, Samuel H. 1; Cohen, Joel W. 1; Source Information: Supplement 1, Vol. 57 Issue S1, p36; Number of Pages: 19p; Document Type: Article; Full Text Word Count: 7176
L3 - 10.1177/107755870005700103
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Brach, Cindy
AU - Fraserirector, Irene
T1 - Can Cultural Competency Reduce Racial and Ethnic Health Disparities? A Review and Conceptual Model.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 181
EP - 217
SN - 10775587
AB - This article develops a conceptual model of cultural competency’s potential to reduce racial and ethnic health disparities, using the cultural competency and disparities literature to lay the foundation for the model and inform assessments of its validity. The authors identify nine major cultural competency techniques: interpreter services, recruitment and retention policies, training, coordinating with traditional healers, use of community health workers, culturally competent health promotion, including family/community members, immersion into another culture, and administrative and organizational accommodations. The conceptual model shows how these techniques could theoretically improve the ability of health systems and their clinicians to deliver appropriate services to diverse populations, thereby improving outcomes and reducing disparities. The authors conclude that while there is substantial research evidence to suggest that cultural competency should in fact work, health systems have little evidence about which cultural competency techniques are effective and less evidence on when and how to implement them properly. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926038; Brach, Cindy 1; Fraserirector, Irene 1; Source Information: Supplement 1, Vol. 57 Issue S1, p181; Number of Pages: 37p; Document Type: Article; Full Text Word Count: 15610
L3 - 10.1177/107755870005700109
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107112389
T1 - Extended Services. Mental health: medication and symptom management.
AU - Moore MJ
Y1 - 2000/04//2000 Apr
N1 - Accession Number: 107112389. Language: English. Entry Date: 20000601. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9500156.
KW - Psychiatric Home Care
KW - Home Nursing, Professional
KW - World Wide Web
KW - Information Resources
KW - Case Mix
KW - Outcome Assessment Information Set
SP - 84
EP - 84
JO - Home Health Focus
JF - Home Health Focus
JA - HOME HEALTH FOCUS
VL - 6
IS - 11
CY - New York, New York
PB - Elsevier Science
SN - 1075-2188
AD - Senior Public Health Nurse, Olmsted County Public Health Service, Rochester, MN
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Black, L.E.
AU - Green, J.D.
AU - Rener, J.
AU - Dayan, A.
AU - Cavagnaro, J.A.
AU - Spindler, P.
AU - Bussiere, J.L.
AU - Bouchard, P.
AU - Inoue, T.
AU - Thomas, P.T.
AU - Essayan, D.M.
AU - Gillett, N.A.
AU - Hart, T.K.
AU - Hastings, K.
AU - House, R.V.
AU - Latta, D.
AU - Liminga, U.
AU - Treacy, G.
AU - Wierda, D.
T1 - Safety evaluation of immunomodulatory biopharmaceuticals: can we improve the predictive value of preclinical studies?
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 205
EP - 207
PB - Sage Publications, Ltd.
SN - 09603271
AB - Presents information about a conference on safety evaluation. Introduction of immunomodulators for diseases of the immune system; Discussion on ways to improve the predictive value of preclinical studies; Topics addressed by papers presented at the conference.
KW - Accident prevention -- Congresses
KW - Immunological adjuvants
KW - Immunologic diseases
N1 - Accession Number: 4664532; Black, L.E. 1; Green, J.D. 2; Rener, J. 3; Dayan, A. 3; Cavagnaro, J.A. 4; Spindler, P. 5; Bussiere, J.L. 6; Bouchard, P. 7; Inoue, T. 8; Thomas, P.T. 3; Essayan, D.M. 1; Gillett, N.A. 9; Hart, T.K. 10; Hastings, K. 11; House, R.V. 3; Latta, D. 12; Liminga, U. 13; Treacy, G. 14; Wierda, D. 15; Affiliations: 1: Center for Biologics Evaluation and Research; 2: Biogen, Inc.; 3: Covance Laboratories; 4: Access BIO; 5: Novo Nordisk A/S Agency; 6: Immunex, Inc.; 7: Genetics Institute; 8: National Institute of Health Sciences, Japan; 9: Sierra Biomedical, Inc.; 10: SmithKline Beecham; 11: Center for Drug Education and Research; 12: Wyeth Ayerst Research; 13: Medical Products Agency, Sweden; 14: CentoCor, Inc.; 15: Lilly Research Laboratories; Issue Info: Apr2000, Vol. 19 Issue 4, p205; Subject Term: Accident prevention -- Congresses; Subject Term: Immunological adjuvants; Subject Term: Immunologic diseases; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Essayan, D.M.
T1 - Clinical trial design for immunomodulatory biologics.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 255
EP - 256
PB - Sage Publications, Ltd.
SN - 09603271
AB - Presents a study on biologic therapeutics. Clinical development of studies on biologic therapeutics; Clinical trial design of immunomodulatory biologics; Safety concerns of immunomodulatory biologics.
KW - Biologicals
KW - Therapeutics
KW - Biologics
KW - clinical trial
KW - Immunomodulatory
KW - pharmacodynamics
KW - pharmacokinetics
KW - preclinical
N1 - Accession Number: 4664533; Essayan, D.M. 1; Affiliations: 1: U.S. Food and Drug Administration, Division of Clinical Trial Design and Analysis, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, HFM-579, 1401 Rockville Pike, Rockville, Maryland 20852-1448, USA; Issue Info: Apr2000, Vol. 19 Issue 4, p255; Thesaurus Term: Biologicals; Subject Term: Therapeutics; Author-Supplied Keyword: Biologics; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: Immunomodulatory; Author-Supplied Keyword: pharmacodynamics; Author-Supplied Keyword: pharmacokinetics; Author-Supplied Keyword: preclinical; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hastings, K.L.
T1 - Assessment of immunosuppressant drug carcinogenicity: standard and alternative animal models.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 261
EP - 265
PB - Sage Publications, Ltd.
SN - 09603271
AB - Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this would mean that rodent carcinogenicity bioassays would be performed under most circumstances. Immunosuppressant drugs have presented unique challenges with respect to the issue of carcinogenicity bioassays. The pharmacological activity of therapeutic immunosuppressants is thought to make them highly likely to act as promoters/cocarcinogens, even in the absence of genotoxic activity. Thus, it is assumed that this class of drug would represent a carcinogenic hazard in the absence of confirmatory standard rodent bioassay data. In addition, rodents typically have been sensitive to the pharmacological/toxicological effects of immunosuppressants. It has proven to be difficult, therefore, to conduct life-time bioassays at doses reasonably equivalent to those that would be used clinically. For this and other reasons, alternative models might be more appropriate for risk assessment with this class of drugs. Human & Experimental Toxicology (2000) 19, 261–265. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity testing
KW - Biological assay
KW - Rodents
KW - Immunosuppressive agents
KW - Homografts
KW - Alternative models
KW - carcinogenicity
KW - Immunosuppressants
N1 - Accession Number: 4664534; Hastings, K.L. 1; Affiliations: 1: US Food and Drug Administration, Division of Special Pathogen and Immunologic Drug Products, Center for Drug Evaluation and Research, Rockville, Maryland 20857, USA; Issue Info: Apr2000, Vol. 19 Issue 4, p261; Thesaurus Term: Carcinogenicity testing; Thesaurus Term: Biological assay; Thesaurus Term: Rodents; Subject Term: Immunosuppressive agents; Subject Term: Homografts; Author-Supplied Keyword: Alternative models; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: Immunosuppressants; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107125993
T1 - Women's health and the environment: innovations in science and policy.
AU - Haynes SG
AU - Lynch GS
AU - Biegel R
AU - Malliou E
AU - Rudick J
AU - Sassaman AP
Y1 - 2000/04//
N1 - Accession Number: 107125993. Language: English. Entry Date: 20000801. Revision Date: 20150711. Publication Type: Journal Article; practice guidelines; review; tables/charts; website. Journal Subset: Biomedical; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 100888719.
KW - Environmental Exposure -- Adverse Effects -- United States
KW - Health Policy -- Legislation and Jurisprudence -- United States
KW - Health Policy -- Trends -- United States
KW - Science
KW - Women's Health
KW - United States
KW - Female
KW - Practice Guidelines
KW - Environmental Exposure -- Legislation and Jurisprudence
KW - Organizations -- Standards
KW - Government Programs -- United States
SP - 245
EP - 273
JO - Journal of Women's Health & Gender-Based Medicine
JF - Journal of Women's Health & Gender-Based Medicine
JA - J WOMENS HEALTH GENDER BASED MED
VL - 9
IS - 3
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - Current scientific findings indicate that environmental factors affect women's health. Specifically, evidence has accumulated on the effects of the environment on reproductive health, cancer, injury, respiratory problems, autoimmune diseases, and other health problems. To review the current state of the science and policies related to women's health and the environment, the Federal Interagency Working Group on Women's Health and the Environment of the Department of Health and Human Services and the Society for Women's Health Research jointly sponsored a conference in 1998 entitled Women's Health and the Environment: Innovations in Science and Policy. The aim of the conference was to provide a forum for scientists to share recent findings, promising avenues of research, methodological barriers, and data gaps about women's susceptibility to environmental agents. The conference generated 22 recommendations for policy, 17 recommendations for communication and training, and 48 recommendations for research to be considered by the federal government. The purpose of this review is to bring to the attention of the scientific community and policymakers the breadth of the women's health implications associated with environmental factors by highlighting key research findings presented at the conference. This review summarizes the current status of science in women's health, it describes relevant activities by the federal government, and it suggests recommendations for future research and policy initiatives in the context of women's health and the environment.
SN - 1524-6094
AD - Assistant Director for Science, Office on Women's Health, US Public Health Service, US Dept of Health and Human Services, Room 712-E, Hubert H. Humphrey Bldg., 200 Independence Ave, SW, Washington, DC 20201
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaylor, D.W.
AU - Kodell, R.L.
T1 - Percentiles of the Product of Uncertainty Factors for Establishing Probabilistic Reference Doses.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2000/04//
VL - 20
IS - 2
M3 - Article
SP - 245
EP - 250
PB - Wiley-Blackwell
SN - 02724332
AB - Exposure guidelines for potentially toxic substances are often based on a reference dose (RfD) that is determined by dividing a no-observed-adverse-effect-level (NOAEL), lowest-observed-adverse-effect-level (LOAEL), or benchmark dose (BD) corresponding to a low level of risk, by a product of uncertainty factors. The uncertainty factors for animal to human extrapolation, variable sensitivities among humans, extrapolation from measured subchronic effects to unknown results for chronic exposures, and extrapolation from a LOAEL to a NOAEL can be thought of as random variables that vary from chemical to chemical. Selected databases are examined that provide distributions across chemicals of inter- and intraspecies effects, ratios of LOAELs to NOAELs, and differences in acute and chronic effects, to illustrate the determination of percentiles for uncertainty factors. The distributions of uncertainty factors tend to be approximately lognormally distributed. The logarithm of the product of independent uncertainty factors is approximately distributed as the sum of normally distributed variables, making it possible to estimate percentiles for the product. Hence, the size of the products of uncertainty factors can be selected to provide adequate safety for a large percentage (e.g., approximately 95%) of RfDs. For the databases used to describe the distributions of uncertainty factors, using values of 10 appear to be reasonable and conservative. For the databases examined the following simple ‘Rule of 3s’ is suggested that exceeds the estimated 95th percentile of the product of uncertainty factors: If only a single uncertainty factor is required use 33, for any two uncertainty factors use 3 × 33 ≈ 100, for any three uncertainty factors use a combined factor of 3 × 100 =: 300, and if all four uncertainty factors are needed use a total factor of 3 × 300 = 900. If near the 99th percentile is desired use another factor of 3. An additional factor may be needed for inadequate data or a modifying factor for other uncertainties (e.g., different routes of exposure) not covered above. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisons
KW - Uncertainty
KW - Probability theory
KW - probabilistic reference dose
KW - Uncertainty factors
N1 - Accession Number: 6632485; Gaylor, D.W. 1; Kodell, R.L. 1; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR.; Issue Info: Apr2000, Vol. 20 Issue 2, p245; Thesaurus Term: Poisons; Subject Term: Uncertainty; Subject Term: Probability theory; Author-Supplied Keyword: probabilistic reference dose; Author-Supplied Keyword: Uncertainty factors; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Qiao, G. L.
AU - Chang, S. K.
AU - Brooks, J. D.
AU - Riviere, J. E.
T1 - Biotransformation and Toxicokinetics. Dermatotoxicokinetic Modeling of p-Nitrophenol and Its Conjugation Metabolite in Swine following Topical and Intravenous Administration.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/04//
VL - 54
IS - 2
M3 - Article
SP - 284
EP - 294
PB - Oxford University Press / USA
SN - 10966080
AB - The development of a dermatotoxicokinetic (dTK) model for p-nitrophenol (PNP), a common metabolite from a variety of compounds and a biomarker of organophosphate (OP) insecticide exposure, may facilitate the kinetic modeling and risk assessment strategy for its parent compounds. In order to quantify and then clarify in vivo-in vitro correlation of PNP disposition, multicompartment kinetic models were formulated. Female weanling pigs were dosed with [14C]PNP intravenously (150 μg in ethanol, n = 4) or topically onto non-occluded abdominal skin (300 μg/7.5cm2 in ethanol, n = 4). PNP and p-nitrophenyl-β-D-glucuronide (PNP-G) profiles were determined in plasma and urine in addition to total 14C quantitation in many other samples. Disposition parameters (rate constants, Ftop, T1/2, T1/2Ka, AUC, Vss, Clp, MAT, and MRT) and the simulated chemical mass-time profiles on the dosed skin surface and in the local, systemic, and excretory compartments were also determined. Total recoveries of 97.17 ± 4.18% and 99.80 ± 2.41% were obtained from topical and intravenous experiments, respectively. Ninety-six hours after topical and intravenous application, 70.92 ± 9.72% and 98.65 ± 2.43% of the dose were excreted via urine, and 0.55 ± 0.16% and 0.51 ± 0.10% via the fecal route, respectively. Peak excretion rate and time were also determined. It was suggested by experimental observation and modeling that urinary 14C excretion correlates with the systemic tissue depletion profile well and may be used as a biomarker of PNP exposure. This study also supports the strategy of using urinary PNP as a biomonitoring tool for OP pesticide exposure, although some precautions have to be taken. The strategy used in this study will be useful in comprehensive dTK modeling in dermal risk assessment and transdermal drug delivery. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dermatotoxicology
KW - Biochemical markers
KW - Cholinesterase reactivators
KW - Pesticides -- Toxicology
KW - Nitrophenols
KW - metabolism
KW - p-nitrophenol (PNP)
KW - pig
KW - skin absorption
KW - toxicokinetics
N1 - Accession Number: 44405937; Qiao, G. L. 1; Email Address: gaq1@cdc.gov; Chang, S. K. 2; Brooks, J. D. 3; Riviere, J. E. 3; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), CDC, Morgantown, West Virginia 26505; 2: Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, Republic of China; 3: Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, Raleigh, North Carolina 27606; Issue Info: Apr2000, Vol. 54 Issue 2, p284; Thesaurus Term: Dermatotoxicology; Thesaurus Term: Biochemical markers; Thesaurus Term: Cholinesterase reactivators; Thesaurus Term: Pesticides -- Toxicology; Subject Term: Nitrophenols; Author-Supplied Keyword: metabolism; Author-Supplied Keyword: p-nitrophenol (PNP); Author-Supplied Keyword: pig; Author-Supplied Keyword: skin absorption; Author-Supplied Keyword: toxicokinetics; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 11p; Illustrations: 1 Diagram, 4 Charts, 10 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105849344
T1 - Food and Drug Administration's proposed approach to regulation of hematopoietic stem/progenitor cell products for therapeutic use.
AU - Harvath L
Y1 - 2000/04//2000 Apr
N1 - Accession Number: 105849344. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8709027.
KW - Hematopoietic Stem Cell Transplantation -- Adverse Effects
KW - Hematopoietic Stem Cells
KW - Legislation, Medical
KW - United States Food and Drug Administration
KW - Fetal Blood
KW - Therapeutics
KW - United States
SP - 104
EP - 111
JO - Transfusion Medicine Reviews
JF - Transfusion Medicine Reviews
JA - TRANSFUS MED REV
VL - 14
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 0887-7963
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
U2 - PMID: 10782496.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107135838
T1 - Acute onset of decreased vision and hearing traced to hemodialysis treatment with aged dialyzers.
AU - Hutter JC
AU - Kuehnert MJ
AU - Wallis RR
AU - Lucas AD
AU - Sen S
AU - Jarvis WR
AU - Hutter, J C
AU - Kuehnert, M J
AU - Wallis, R R
AU - Lucas, A D
AU - Sen, S
AU - Jarvis, W R
Y1 - 2000/04/26/
N1 - Accession Number: 107135838. Language: English. Entry Date: 20001001. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Hemodialysis -- Adverse Effects
KW - Dialysis Equipment and Supplies
KW - Neurologic Manifestations
KW - Retrospective Design
KW - Prospective Studies
KW - Hearing Disorders
KW - Vision Disorders
KW - Headache
KW - Conjunctivitis
KW - Human
SP - 2128
EP - 2134
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 283
IS - 16
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: A recent event in which 7 patients at 1 hospital developed decreased vision and hearing, conjunctivitis, headache, and other severe neurologic symptoms 7 to 24 hours after hemodialysis drew attention to the issue of the long-term integrity of dialysis machines and materials.Objective: To determine the cause of the adverse reactions that occurred during this event.Design, Patients, and Setting: Retrospective cohort study of all 9 patients who received hemodialysis at hospital A on September 18, 1996, the day of the outbreak. A case-patient was defined as any hospital A patient with acute onset of decreased vision and hearing and conjunctivitis after dialysis on that day. Non-case-patients were all others who underwent dialysis at hospital A on that day but did not develop adverse reactions. In an attempt to reproduce the conditions of the event, cellulose acetate dialysis membranes of various ages were retrieved from other sources and tested for physical and chemical degradation, and degradation products were identified, characterized, and injected intravenously into rabbits.Main Outcome Measures: Clinical signs and symptoms, time to resolution of symptoms, mortality, and dialyzer type and age, for case- vs non-case-patients.Results: Seven of the 9 patients met the case definition. In addition to diminished vision and hearing, conjunctivitis, and headache, some case-patients had blood leak alarm activation (n=6), confusion/lethargy (n=5), corneal opacification (n=4), cardiac arrest (n=2), or other neurologic signs and symptoms. One case-patient died during hospitalization after the event; 5 of 7 case-patients died within 13 months. Resolution of signs and symptoms varied but persisted more than 3 years or until death in 3 of the 6 patients who survived hospitalization. All case-patients but no non-case-patients were exposed to 11.5-year-old cellulose acetate dialyzers (all of these dialyzers were discarded by the hospital before our investigation). Laboratory investigation of field-retrieved 0- to 13.6-year-old dialyzers of similar type indicated significant chemical degradation in the older membranes. In vivo injection of extracts of membrane degradation products produced iritis and hemorrhages in rabbits' eyes.Conclusions: Severe patient injury was associated with exposure to aged cellulose acetate membranes of dialyzers, allowing cellulose acetate degradation products to enter the blood. Clinicians should be aware that aged cellulose acetate membranes may cause severe adverse reactions.
SN - 0098-7484
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852, USA
AD - Center for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Pkwy, HFZ-150, Rockville, MD 20852 (jch@cdrh.fda.gov)
U2 - PMID: 10791505.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107031864
T1 - Industrial responses to constrained OSHA regulation.
AU - Pedersen DH
Y1 - 2000/05//2000 May-Jun
N1 - Accession Number: 107031864. Language: English. Entry Date: 20010622. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100939625.
KW - United States Occupational Safety and Health Administration -- Standards
KW - Industry
KW - Surveys
KW - Occupational Health Services
KW - Comparative Studies
KW - Correlation Coefficient
KW - Descriptive Statistics
KW - Occupational Safety
KW - Human
SP - 381
EP - 387
JO - AIHAJ
JF - AIHAJ
JA - AIHAJ
VL - 61
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - As part of the effort to reduce the size and economic impact of the federal establishment, congressional conservatives are proposing legislation to restrict the regulatory activity of the Occupational Safety and Health Administration (OSHA). These proposals push OSHA toward a purely consultative role, at a corresponding cost in direct regulatory capability. The Clinton administration's reinvention of government initiative is also moving OSHA toward a consultative role based on a strategy of cooperative compliance or industry self-regulation with a strong coercive foundation. Since both camps appear to agree that self-regulation can assure a safe and healthy workplace, the remaining debate concerns the extent to which coercive regulation is still needed. National survey data on the industrial provision of occupational safety and health services in the manufacturing sector were used to measure changes in industrial safety and health activity between 1972-74 and 1981-83. In conjunction with data on OSHA command-and-control regulatory activity from 1972 to 1979, these data permitted an examination of the relationship between command-and-control regulatory activities and changes in industrial behavior that could be regarded as a form of self-regulation. This analysis showed that coercive regulation by OSHA in the 1970s was significantly related to industry self-regulation efforts, although the relationship varied by industrial facility employment size and type of regulatory coercion. These results indicate that coercive regulation should be retained as an industrial incentive in any self-regulation policy paradigm. The results also provide evidence that OSHA regulatory policy should be based on anticipated differences in industrial response to various coercive measures.
SN - 1529-8663
AD - Health Related Energy Research Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health (MS R-44) 4676 Columbia Parkway, Cincinnati, Ohio 45226
U2 - PMID: 10885888.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107030538
T1 - Effectiveness of food fortification in the United States: the case of Pellagra.
AU - Park YK
AU - Sempos CT
AU - Barton CN
AU - Vanderveen JE
AU - Yetley EA
Y1 - 2000/05//
N1 - Accession Number: 107030538. Language: English. Entry Date: 20010615. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Food, Fortified -- Legislation and Jurisprudence -- United States
KW - Pellagra -- Prevention and Control
KW - Niacin -- Deficiency
KW - Health Policy -- Evaluation
KW - Pellagra -- Epidemiology
KW - Evaluation Research
KW - Comparative Studies
KW - Vital Statistics
KW - Mortality
KW - Economics
KW - Data Analysis Software
KW - Correlation Coefficient
KW - Multiple Regression
KW - Correlational Studies
KW - Morbidity
KW - P-Value
KW - Deficiency Diseases
KW - Pellagra -- Mortality
KW - Income
KW - Socioeconomic Factors
KW - Southeastern United States
KW - Sex Factors
KW - Race Factors
KW - Food Supply
KW - United States
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 727
EP - 738
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 90
IS - 5
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We evaluated the possible role of niacin fortification of the US food supply and other concurrent influences in eliminating the nutritional deficiency disease pellagra. METHODS: We traced chronological changes in pellagra mortality and morbidity and compared them with the development of federal regulations, state laws, and other national activities pertaining to the fortification of cereal-grain products with niacin and other B vitamins. We also compared these changes with other concurrent changes that would have affected pellagra mortality or morbidity. RESULTS: The results show the difficulty of evaluating the effectiveness of a single public health initiative such as food fortification without controlled experimental trials. Nonetheless, the results provide support for the belief that food fortification played a significant role in the elimination of pellagra in the United States. CONCLUSIONS: Food fortification that is designed to restore amounts of nutrients lost through grain milling was an effective tool in preventing pellagra, a classical nutritional deficiency disease, during the 1930s and 1940s, when food availability and variety were considerably less than are currently found in the United States.
SN - 0090-0036
AD - Food and Drug Administration, Office of Nutritional Products, Labeling, and Dietary Supplements, 200 C St SW, HFS-832, Washington, DC 20204. E-mail: ypark@cfsan.fda.gov
U2 - PMID: 10800421.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Proctor, Enola K.
AU - Morrow-Howell, Nancy
AU - Hong Li
AU - Dore, Peter
T1 - ADEQUACY OF HOME CARE AND HOSPITAL READMISSION FOR ELDERLY CONGESTIVE HEART FAILURE PATIENTS.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 2000/05//
VL - 25
IS - 2
M3 - Article
SP - 87
PB - Oxford University Press / USA
SN - 03607283
AB - Readmission to acute care facilities is a frequent and costly problem among older adults with congestive heart failure (CHF). The study reported in this article tested the hypothesis that adequate home care, operationalized as patient-perceived adequacy of formal and informal assistance, is associated with lower readmission to acute care facilities. The study followed 253 elderly (age 65 and older) Medicare patients discharged to their homes after hospitalization for CHF, through structured telephone interviews at two, six, 10, and 14 weeks postdischarge. Study findings point to the importance of home care in reducing the high risk of readmission among elderly patients. The findings raise implications for practice, policy and research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health & Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER people -- Home care
KW - CONGESTIVE heart failure
KW - OLDER people
KW - MEDICAL care for the aged
KW - CARING
KW - HEALTH facilities -- Discharge planning
KW - congestive heart failure
KW - discharge planning
KW - elderly people
KW - home care
KW - readmission
N1 - Accession Number: 3151393; Proctor, Enola K. 1; Email Address: ekp@gwbmail.wustl.edu; Morrow-Howell, Nancy 2; Hong Li 3; Dore, Peter 4; Source Information: May2000, Vol. 25 Issue 2, p87; Subject: OLDER people -- Home care; Subject: CONGESTIVE heart failure; Subject: OLDER people; Subject: MEDICAL care for the aged; Subject: CARING; Subject: HEALTH facilities -- Discharge planning; Author-Supplied Keyword: congestive heart failure; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: home care; Author-Supplied Keyword: readmission; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6249
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hnizdo, E.
AU - Murray, J.
AU - Davison, A.
T1 - Correlation between autopsy findings for chronic obstructive airways disease and in-life disability in South African gold miners.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2000/05//
VL - 73
IS - 4
M3 - Article
SP - 235
EP - 244
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Objectives: In South Africa chronic obstructive airway disease (COAD), which could be due to working in a dusty atmosphere in scheduled mines or works, is a compensatable disease. Miners are compensated for in-life respiratory disability and for findings at autopsy of COAD, which includes emphysema, bronchitis assessed by mucus gland hyperplasia in the main bronchus, and bronchiolitis assessed by goblet cell metaplasia. The question arises as to whether the autopsy findings correlate with in-life impairment. The objectives of the study were: (1) to determine whether autopsy COAD outcomes relate to lung function and to respiratory symptoms and signs; and (2) to quantify the individual contributions of emphysema, bronchiolitis and bronchitis to lung function impairment. Methods: On 724 gold miners, pathological findings of COAD – emphysema, bronchitis and bronchiolitis – were related to lung function measurements and respiratory symptoms and signs observed within 5 years prior to death. Results: Emphysema diagnosed at autopsy was the main determinant of airflow impairment. The emphysema score categories 0–5, 5–35, 35–65 and >65 were associated with decreased forced expiratory volume in 1 s, expressed as percentage predicted (FEV1%) as follows: 78.8%, 66.2%, 52.0% and 46.0%, respectively. The score was also associated with increasing frequency of dyspnoea. After adjustment for emphysema, the bronchitis and bronchiolitis were not related to significant lung function loss, and in subjects without emphysema, the presence of moderate or marked bronchitis was associated with a mild impairment only. Bronchitis at autopsy was associated with increased frequency of rhonchi, sputum and cough, whereas bronchiolitis was associated with increased sputum only. Silicosis found at autopsy was associated with some obstructive and restrictive lung function impairment. Tobacco smoking was associated with all the COAD outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Respiratory diseases
KW - Airway (Medicine)
KW - Autopsy
KW - Bronchitis
KW - Obstructive lung diseases
KW - South Africa
KW - Bronchiolitis
KW - Clinico-pathological correlations
KW - Emphysema
KW - Lung function
KW - Silica dust
N1 - Accession Number: 16132772; Hnizdo, E. 1,2,3; Email Address: EXH6@cdc.gov; Murray, J. 2,3; Davison, A. 2,3; Affiliations: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2800 Morgantown, WV 26505-2845, USA; 2: National Centre for Occupational Health, Johannesburg, South Africa; 3: Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa; Issue Info: May2000, Vol. 73 Issue 4, p235; Subject Term: Respiratory diseases; Subject Term: Airway (Medicine); Subject Term: Autopsy; Subject Term: Bronchitis; Subject Term: Obstructive lung diseases; Subject: South Africa; Author-Supplied Keyword: Bronchiolitis; Author-Supplied Keyword: Clinico-pathological correlations; Author-Supplied Keyword: Emphysema; Author-Supplied Keyword: Lung function; Author-Supplied Keyword: Silica dust; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Galvin, Deborah M.
AU - Galvin, D M
T1 - Workplace managed care: collaboration for substance abuse prevention.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 2000/05//
VL - 27
IS - 2
M3 - journal article
SP - 125
EP - 130
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - This article describes the history, purpose, and overall methodology of the Workplace Managed Care (WMC) study sponsored by the Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention (CSAP). This study was initiated to discern best practices for workplaces and managed care organizations integrating their substance abuse prevention and early intervention programs, strategies, and activities for employees and their families. CSAP funded nine WMC grants to study their retrospective and prospective data. Results of the WMC study suggested the addition of substance abuse prevention material to existing workplace health promotion offerings that resulted in improved substance abuse attitudes without jeopardizing existing health promotion programs. Stress management programming was successful at improving substance abuse attitudes indirectly. This study provides a platform for multidisciplinary research in workplace and managed care settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Behavioral Health Services & Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - SUBSTANCE abuse -- Prevention
KW - EMPLOYEE health promotion
KW - UNITED States
N1 - Accession Number: 3064017; Galvin, Deborah M.; Galvin, D M 1; Source Information: May2000, Vol. 27 Issue 2, p125; Subject: SUBSTANCE abuse; Subject: SUBSTANCE abuse -- Prevention; Subject: EMPLOYEE health promotion; Geographic Terms: UNITED States; Number of Pages: 6p; Document Type: journal article; Full Text Word Count: 3514
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106583494
T1 - Detection of Norwalk-like virus in shellfish implicated in illness.
AU - Shieh YC
AU - Monroe SS
AU - Fankhauser RL
AU - Langlois GW
AU - Burkhardt W III
AU - Baric RS
Y1 - 2000/05//5/1/2000
N1 - Accession Number: 106583494. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - RNA Virus Infections -- Diagnosis
KW - Food Contamination
KW - Disease Outbreaks
KW - Gastroenteritis -- Epidemiology
KW - Gastroenteritis -- Etiology
KW - Shellfish
KW - Polymerase Chain Reaction
SP - S360
EP - 6
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 181
IS - 5
PB - Oxford University Press / USA
AB - In the 1990s, Norwalk-like viruses (NLVs) were identified in patient specimens as the primary pathogen associated with shellfish-borne gastroenteritis in the United States. Identification of these viruses from implicated shellfish has been difficult due to inefficient recovery of viruses, natural polymerase chain reaction (PCR) inhibitors in shellfish, and low virus contamination. Recent improvements to the method of detecting NLVs in shellfish include enhanced processing of virus and shellfish samples, application of nested PCR and nucleotide sequencing, and increased knowledge of NLV genetic diversity. Using a newly developed and sensitive method, an NLV G2 strain was identified in 2 oyster samples implicated in a 1998 California outbreak involving 171 cases. NLV capsid primers demonstrated a greater specificity of PCR detection than did polymerase primers. The 175-base viral capsid nucleotide sequences derived from oysters were 100% identical to those derived from a patient stool sample. This finding supports the epidemiologic associations indicating that contaminated Copyright © 2000 The University of Chicago
SN - 0022-1899
AD - US Food and Drug Administration Gulf Coast Seafood Laboratory, PO Box 158, Dauphin Island, AL 36528; yshieh@cfsan.fda.gov
U2 - PMID: 10804149.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106583494&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107114155
T1 - Device safety. Protecting your patient's eyes.
AU - Woo EK
Y1 - 2000/05//
N1 - Accession Number: 107114155. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Keratitis -- Chemically Induced
KW - Contact Lenses
KW - Solutions -- Adverse Effects
SP - 81
EP - 81
JO - Nursing
JF - Nursing
JA - NURSING
VL - 30
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 10855206.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bowyer, John F.
AU - Newport, Glenn D.
AU - Slikker Jr., William
AU - Gough, Bobby
AU - Ferguson, Sherry A.
AU - Tor-Agbidye, John
T1 - An Evaluation of l-Ephedrine Neurotoxicity with Respect to Hyperthermia and Caudate/Putamen Microdialysate Levels of Ephedrine, Dopamine, Serotonin, and Glutamate.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/05//
VL - 55
IS - 1
M3 - Article
SP - 133
EP - 142
PB - Oxford University Press / USA
SN - 10966080
AB - l-Ephedrine is an active ingredient in several herbal formulations with a mechanism of action similar to amphetamine and methamphetamine. However, its potential to damage dopaminergic terminals in the caudate/putamen (CPu) has yet to be fully evaluated. The studies here used in vivo brain microdialysis experiments to determine the systemic doses and extracellular brain levels of l-ephedrine necessary to produce similar increases in CPu extracellular dopamine and marked hyperthermia that were previously shown necessary for amphetamine-induced neurotoxicity in male Sprague-Dawley rats. At an environmental temperature of 23°C, a single 40 mg/kg intraperitoneal (ip) dose of l-ephedrine produced marked hyperthermia (≥ 40°C), peak microdialysate ephedrine levels of 7.3 ± 1.2 μM, and a 20-fold increase in microdialysate dopamine levels. Twenty-five mg/kg produced a lesser degree of hyperthermia, peak microdialysate ephedrine levels of 2.6 ± 0.4 μM, and a 10-fold increase in dopamine levels. Three doses of 40 mg/kg given at 3-h intervals or 4 doses of 25 mg/kg l-ephedrine given at 2-h intervals were compared with 4 doses of 5 mg/kg d-amphetamine given at 2-h intervals. Multiple doses of either ephedrine or amphetamine caused severe hyperthermia (≥ 41.3°C) but striatal tissue levels of dopamine 7 days after dosing were reduced only 25% or less by ephedrine compared to the 75% reductions produced by amphetamine. The increases in CPu microdialysate levels of serotonin produced by either 4 × 25 mg/kg l-ephedrine or 4 × 5 mg/kg d-amphetamine did not significantly differ, but elevation of dopamine levels by d-amphetamine were over 2-fold times the level caused by l-ephedrine. Microdialysate glutamate levels were elevated to the same extent by either 25 mg/kg l-ephedrine or 4 × 5 mg/kg d-amphetamine. l-Ephedrine may not be as neurotoxic to dopaminergic terminals as d-amphetamine, because non-lethal doses of l-ephedrine do not sufficiently increase the CPu dopamine levels within nerve terminals or the extracellular space to those necessary for a more pronounced long-term dopamine depletion. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Ephedrine
KW - Neurotoxicology
KW - Herbal medicine
KW - Dopaminergic neurons
KW - Dopamine
KW - Serotonin
KW - Fever
KW - Drugs
KW - dopamine
KW - ephedrine
KW - microdialysis
KW - neurotoxicity
KW - serotonin
KW - striatum
N1 - Accession Number: 44405970; Bowyer, John F. 1; Email Address: jbowyer@nctr.fda.gov; Newport, Glenn D. 1; Slikker Jr., William 1; Gough, Bobby 1; Ferguson, Sherry A. 1; Tor-Agbidye, John 1; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: May2000, Vol. 55 Issue 1, p133; Thesaurus Term: TOXICOLOGY; Subject Term: Ephedrine; Subject Term: Neurotoxicology; Subject Term: Herbal medicine; Subject Term: Dopaminergic neurons; Subject Term: Dopamine; Subject Term: Serotonin; Subject Term: Fever; Subject Term: Drugs; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: ephedrine; Author-Supplied Keyword: microdialysis; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: serotonin; Author-Supplied Keyword: striatum; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Illustrations: 4 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107120638
T1 - Viewpoint. Let's get down to business.
AU - Mazzella CB
Y1 - 2000/06//
N1 - Accession Number: 107120638. Language: English. Entry Date: 20000701. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Health Care Delivery
KW - Business
KW - Nursing Care
SP - 9
EP - 9
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 100
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Assistant Surgeon General and Chief Nurse Officer, US Public Health Service, Rockville, MD
U2 - PMID: 10892319.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107001560
T1 - Four earplugs in search of a rating system.
AU - Franks JR
AU - Murphy WJ
AU - Johnson JL
AU - Harris DA
Y1 - 2000/06//2000 Jun
N1 - Accession Number: 107001560. Language: English. Entry Date: 20010223. Revision Date: 20150820. Publication Type: Journal Article; equations & formulas; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Interagency Agreement between U.S. EPA and NIOSH (75090527). NLM UID: 8005585.
KW - Ear Protective Devices -- Evaluation
KW - Noise
KW - Occupational Exposure -- Prevention and Control
KW - Auditory Threshold
KW - Funding Source
KW - Ear Protective Devices -- Standards
KW - Product Evaluation
KW - Equipment Design
KW - Audiometry
KW - Descriptive Statistics
KW - Human
SP - 218
EP - 226
JO - Ear & Hearing (01960202)
JF - Ear & Hearing (01960202)
JA - EAR HEAR
VL - 21
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: The performance of four insert earplugs was evaluated by determining the Noise Reduction Rating (NRR) and the Subject-Fit Noise Reduction Rating [NRR(SF)]. The NRR and NRR(SF) were calculated from real-ear attenuation at threshold (REAT) data collected using the experimenter-fit protocol described in the now-rescinded ANSI S3.19-1974 (American National Standards Institute, 1974) and the subject-fit protocol of the recently revised ANSI S12.6-1997 (American National Standards Institute, 1997) standards for REAT measurement. DESIGN: A comparison of the experimenter-fit and subject-fit REAT performance was conducted using four pools of subjects, one pool per protector. Each device was tested with at least 20 subjects, the minimum size necessary to estimate the NRR(SF) for an earplug. The REAT was measured with third-octave narrowband noise stimuli for center frequencies at 0.125, 0.25,0.5, 1, 2, 3.15, 4, 6.3, and 8 kHz. The REAT means and standard deviations were compared with the manufacturer data. RESULTS: This study showed that the NRR(SF) is typically lower than the NRR and that the NRR(SF) is not well-predicted by the NRR derating schemes recommended by the National Institute for Occupational Safety and Health and required by the Occupational Safety and Health Administration. CONCLUSION: The difference between the present NRR on hearing protector labels and the NRR(SF) is sufficiently large and unpredictable enough to render the application of derating schemes meaningless even though these schemes attempt to account for the difference between the laboratory and real-world outcomes. The only way to provide a protector noise rating that is predictive of a real-world outcome is to retest the protector according to the subject-fit method of ANSI S12.6-1997 (American National Standards Institute, 1997).
SN - 0196-0202
AD - Chief, Hearing Loss Prevention Section, National Institute for Occupational Safety and Health, Mail-Stop C-27, 4676 Columbia Pkwy, Cincinnati, OH 45226-1998
U2 - PMID: 10890730.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Razzaghi, Mehdi
AU - Kodell, Ralph
T1 - Dose-response modeling for developmental neurotoxicity data.
JO - Environmental & Ecological Statistics
JF - Environmental & Ecological Statistics
Y1 - 2000/06//
VL - 7
IS - 2
M3 - Article
SP - 191
EP - 203
PB - Springer Science & Business Media B.V.
SN - 13528505
AB - The fact that maternal exposures to some chemicals during pregnancy can adversely affect the structure and function of the nervous system in the offspring is well established. Government agencies have for a long time been concerned with regulation of developmental neurotoxicants and safe perinatal exposures. However, despite this concern, current guidelines provide only broad and nonspecific recommendations and lack clear directions for a model based approach to risk estimation. In this paper we propose a dose-response model for the nonquantal data obtained from developmental neurotoxicological experiments. To account for the critical issue of the correlation among responses from pups in the same litter, the so called intralitter correlation, a hierarchical distributional structure is used to derive the underlying unconditional distribution of responses. The maximum likelihood method is used to estimate model parameters and the covariance matrix of the estimates is derived. An example is used to illustrate the results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Ecological Statistics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Toxicology
KW - Experimental toxicology
KW - Chemicals -- Physiological effect
KW - Neurotoxicology
KW - Pregnancy complications
KW - Nervous system
KW - intralitter correlation
KW - maximum likelihood
KW - neurotoxic effect
KW - nonquantal data
N1 - Accession Number: 16866721; Razzaghi, Mehdi 1; Email Address: razzaghi@bloomu.edu; Kodell, Ralph 2; Affiliations: 1: Bloomsburg University, PA, USA and NCTR, FDA; 2: National Center for Toxicological Research (NCTR) US Food and Drug Administration (FDA) Jefferson, AR, USA; Issue Info: Jun2000, Vol. 7 Issue 2, p191; Thesaurus Term: DISEASES; Thesaurus Term: Toxicology; Thesaurus Term: Experimental toxicology; Thesaurus Term: Chemicals -- Physiological effect; Subject Term: Neurotoxicology; Subject Term: Pregnancy complications; Subject Term: Nervous system; Author-Supplied Keyword: intralitter correlation; Author-Supplied Keyword: maximum likelihood; Author-Supplied Keyword: neurotoxic effect; Author-Supplied Keyword: nonquantal data; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104722262
T1 - Vibrio gastroenteritis in the US Gulf of Mexico region: the role of raw oysters.
AU - Altekruse, S F
AU - Bishop, R D
AU - Baldy, L M
AU - Thompson, S G
AU - Wilson, S A
AU - Ray, B J
AU - Griffin, P M
Y1 - 2000/06//2000 Jun
N1 - Accession Number: 104722262. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Food Contamination
KW - Gastroenteritis
KW - Mollusca
KW - Shellfish
KW - Vibrio Infections -- Epidemiology
KW - Adult
KW - Animals
KW - Education
KW - Female
KW - Gastroenteritis -- Etiology
KW - Gastroenteritis -- Pathology
KW - Male
KW - Risk Factors
KW - Seasons
KW - Southeastern United States
KW - Vibrio Infections -- Etiology
KW - Vibrio Infections -- Pathology
SP - 489
EP - 495
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 124
IS - 3
PB - Cambridge University Press
AB - We examined clinical and epidemiological features of 575 laboratory-confirmed cases of vibrio gastroenteritis in Alabama, Florida, Louisiana, and Texas from 1988 to 1997 (the US Gulf of Mexico Regional Vibrio Surveillance System). Illnesses occurred year round, with peaks in spring and autumn. Illnesses lasted a median of 7 days and included fever in half of patients and bloody stools in 25% of patients with relevant information. Seventy-two percent of patients reported no underlying illnesses. In the week before onset, 236 (53%) of 445 patients for whom data were available ate raw oysters, generally at a restaurant or bar. Educational efforts should address the risk of vibrio gastroenteritis for raw oyster consumers, including healthy individuals. Further studies should examine environmental conditions affecting vibrio counts on seafood and processing technologies to enhance the safety of raw oysters.
SN - 0950-2688
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA.
U2 - PMID: 10982073.
DO - 10.1017/S0950268899003714
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Turturro, A.
AU - Hass, B.S.
AU - Hart, R.W.
T1 - Response to the commentaries on “Does caloric restriction induce hormesis?”.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/06//
VL - 19
IS - 6
M3 - Article
SP - 355
EP - 359
PB - Sage Publications, Ltd.
SN - 09603271
AB - Responds to a comment on the role of caloric restriction in hormesis. Concerns raised about the concept of malnutrition; Inconsistencies in the definitions of the components of hormesis; Limitations of the Gompertzian analysis.
KW - Low-calorie diet
KW - Hormesis
N1 - Accession Number: 4664186; Turturro, A. 1; Hass, B.S. 2; Hart, R.W. 3; Affiliations: 1: Food and Drug Administration, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079 (NCTR) USA; 2: NCTR, Division of Genetic and Reproductive Toxicology; 3: NCTR, Office of the Director; Issue Info: Jun2000, Vol. 19 Issue 6, p355; Subject Term: Low-calorie diet; Subject Term: Hormesis; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cohen, Steven B.
T1 - Guest editor's preface.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/06//
VL - 26
IS - 2
M3 - Article
SP - 79
EP - 81
PB - IOS Press
SN - 07479662
AB - Introduces a series of articles on medical care surveys in the U.S.
KW - MEDICAL care surveys
KW - HEALTH surveys -- United States
N1 - Accession Number: 4832979; Cohen, Steven B. 1; Affiliations: 1: Acting Director, Center for Cost and Financing Studies Director, Division of Statistical Research and Methods Agency for Healthcare Research and Quality 2101 East Jefferson Street, Suite 500 Rockville, MD 20852 USA; Issue Info: 2000, Vol. 26 Issue 2, p79; Subject Term: MEDICAL care surveys; Subject Term: HEALTH surveys -- United States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Cohen, Steven B.
AU - Machlin, Steven R.
T1 - Survey attrition considerations in the Medical Expenditure Panel Survey.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/06//
VL - 26
IS - 2
M3 - Article
SP - 83
EP - 98
PB - IOS Press
SN - 07479662
AB - In panel designs with multiple waves of data collection, the overall survey response rate is a multiplicative function of the wave specific response rates. The 1996 Medical Expenditure Panel Survey (MEPS) Household Component follows this model to acquire data on health care use, expenditures, insurance coverage and sources of payment that cover two consecutive calendar years. An overlapping panel design was implemented, where data covering the second year of a panel are combined with data from the first year of a new panel. This study identifies the characteristics that distinguish survey participants across waves of the survey from those that only participate in initial rounds and then discontinue their survey participation. The results provide insights regarding the efficacy of the MEPS nonresponse adjustment strategies by comparing the survey estimates from the second year of the longitudinal panel with those from a new panel for the same time period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPONSE rates
KW - HEALTH insurance
KW - HEALTH surveys
KW - MEDICAL care costs
KW - MEDICAL care use
N1 - Accession Number: 4832983; Cohen, Steven B. 1; Machlin, Steven R. 1; Affiliations: 1: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 2101 E. Jefferson Street, Suite 500, Rockville, MD 20852, USA; Issue Info: 2000, Vol. 26 Issue 2, p83; Thesaurus Term: RESPONSE rates; Thesaurus Term: HEALTH insurance; Subject Term: HEALTH surveys; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care use; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Cohen, Steven B.
AU - Yu, William W.
T1 - The impact of alternative sample allocation schemes on the precision of survey estimates derived from the National Medical Expenditure Panel Survey.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/06//
VL - 26
IS - 2
M3 - Article
SP - 111
EP - 128
PB - IOS Press
SN - 07479662
AB - The 1996 Medical Expenditure Panel Survey - Household Component (MEPS-HC) was designed as a continuous on-going survey to permit annual estimates of health care utilization, expenditures, insurance coverage and sources of payment for the U.S. civilian noninstitutionalized population. Selected as a nationally representative subsample from the National Health Interview Survey, it is characterized by a multi-stage area probability design with an oversample of households with Hispanics and blacks. The 1996 MEPS sample consists of 195 primary sampling units (PSUs) which contained 10,597 responding NHIS households. In this paper, the precision of survey estimates derived from a 195 PSU design is compared with precision results for alternative sample allocation schemes that preserve the number of sample respondents and the over-sampling of minorities, while varying the number of PSUs and segments. The results provide insights on the impact of alternative sample allocation schemes on the precision of national health care estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - MEDICAL care surveys
KW - MEDICAL care costs
KW - HEALTH surveys -- United States
KW - MEDICAL care use
KW - UNITED States
N1 - Accession Number: 4832981; Cohen, Steven B. 1; Yu, William W. 1; Affiliations: 1: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 2101 E. Jefferson St., Suite 500, Rockville, MD 20852, USA; Issue Info: 2000, Vol. 26 Issue 2, p111; Thesaurus Term: MEDICAL care; Subject Term: MEDICAL care surveys; Subject Term: MEDICAL care costs; Subject Term: HEALTH surveys -- United States; Subject Term: MEDICAL care use; Subject Term: UNITED States; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Winglee, Marianne
AU - Valliant, Richard
AU - Brick, J. Michael
AU - Machlin, Steven
T1 - Probability matching of medical events.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/06//
VL - 26
IS - 2
M3 - Article
SP - 129
EP - 140
PB - IOS Press
SN - 07479662
AB - This paper discusses the methods of probability record linkage and error estimation for the Medical Expenditure Panel Survey (MEPS). MEPS collects medical expenditure data from both household respondents and their medical providers. The medical events reported by the two sources are subject to reporting differences and probability linkage methods are used to determine if pairs of medical events belong to the same entities. Match weights are assigned to pairs of events based on the likelihood of being a match, and a decision made to declare pairs as matches or nonmatches. The linkage errors include false matches (false positive) when pairs selected are not true matches, and false nonmatches (false negative) when true pairs are omitted. This study used three approaches: manual reviews, cumulative weight curves, and simulation approaches to provide estimates of linkage errors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - MEDICAL record linkage
KW - ERRORS
KW - MEDICAL care costs
KW - MEDICAL care surveys
N1 - Accession Number: 4832980; Winglee, Marianne 1; Valliant, Richard 1; Brick, J. Michael 1; Machlin, Steven 2; Affiliations: 1: Westat Inc., 1650 Research Boulevard, Rockville, MD 20850, USA; 2: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 2101 E. Jefferson Street, Suite 500 Rockville, MD 20852, USA; Issue Info: 2000, Vol. 26 Issue 2, p129; Thesaurus Term: PROBABILITY theory; Subject Term: MEDICAL record linkage; Subject Term: ERRORS; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care surveys; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Machlin, Steven R.
AU - Cohen, Joel W.
AU - Thorpe, Joshua M.
T1 - Measuring inpatient care use in the United States: A comparison across five federal data sources.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/06//
VL - 26
IS - 2
M3 - Article
SP - 141
EP - 151
PB - IOS Press
SN - 07479662
AB - Despite declines in recent years, inpatient care remains the largest component of national medical expenditures. The U.S. Department of Health and Human Services currently sponsors five data collection efforts that can be used to estimate the utilization of inpatient hospital care in the United States. Through a comparison of 1996 inpatient utilization estimates, this paper describes important methodological considerations when using the different data sources for measuring inpatient use. Our results show that surveys with similar target populations and methodologies produced similar estimates. In particular, estimates for the household based surveys (NHIS and MEPS-HC) were comparable while those for the hospital discharge surveys (NHDS and HCUP-NIS) were comparable. Hospital discharge surveys produced substantially higher estimates of total discharges than household surveys, which is partly attributable to differences in target populations. Also, data from the MCBS suggest that underreporting may be another explanation for lower estimates from the household surveys. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - INPATIENT care
KW - HOSPITAL care
KW - MEDICAL care surveys
KW - UNITED States
KW - benchmarking
KW - data collection
KW - HCUP
KW - healthcare surveys
KW - Hospital utilization
KW - MCBS
KW - MEPS
KW - NHDS
KW - NHIS
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 4832978; Machlin, Steven R. 1; Cohen, Joel W. 1; Thorpe, Joshua M. 1; Affiliations: 1: Agency for Healthcare Research and Quality, Executive Office Center, Suite 500, 2101 E. Jefferson Street, Rockville, MD 20852, USA; Issue Info: 2000, Vol. 26 Issue 2, p141; Thesaurus Term: MEDICAL care; Subject Term: INPATIENT care; Subject Term: HOSPITAL care; Subject Term: MEDICAL care surveys; Subject: UNITED States; Author-Supplied Keyword: benchmarking; Author-Supplied Keyword: data collection; Author-Supplied Keyword: HCUP; Author-Supplied Keyword: healthcare surveys; Author-Supplied Keyword: Hospital utilization; Author-Supplied Keyword: MCBS; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: NHDS; Author-Supplied Keyword: NHIS ; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106907826
T1 - The stages of pain processing across the adult lifespan [corrected] [published erratum appears in J PAIN 2000 Fall; 1(3): 243].
AU - Riley JL III
AU - Wade JB
AU - Robinson ME
AU - Price DD
Y1 - 2000///2000 Summer
N1 - Accession Number: 106907826. Language: English. Entry Date: 20020315. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Psychosocial Pain Inventory. NLM UID: 100898657.
KW - Chronic Pain -- Psychosocial Factors
KW - Models, Theoretical
KW - Clinical Assessment Tools
KW - Age Factors
KW - Visual Analog Scaling
KW - Scales
KW - Pain Measurement
KW - Analysis of Covariance
KW - LISREL
KW - Chi Square Test
KW - One-Way Analysis of Variance
KW - Two-Way Analysis of Variance
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Male
KW - Human
SP - 162
EP - 170
JO - Journal of Pain
JF - Journal of Pain
JA - J PAIN
VL - 1
IS - 2
PB - Churchill Livingstone, Inc.
AB - The purpose of this study was is to examine age-related differences in a 4-stage model of the processing of chronic pain. This study used data collected from 1585 chronic pain patients that were divided into 3 age cohorts: younger adults 18-44 years old (n = 895), middle-aged adults 45-64 years old (n = 538), older adults 65-85 years old (n = 159). Using an analyasis of covariate analysis (ANCOVA) model, mean differences across the age cohort were found on the third (emotional distress) and fourth (pain behavior) stages of the pain processing model. The older adult group reported less emotional response to pain and less pain behavior than the younger or middle-aged groups. Age cohort differences in the linear relationship between stages were tested using structural equation modeling. The middle-aged group showed the highest association between their emotional responses to pain and pain behaviors, and the older group showed the least association. No differences in magnitude or association were found for the 2 initial stages of pain processing (usual pain intensity or pain unpleasantness). These differences are likely to be a function of differences in life circumstances, attitudes and beliefs about pain and/or aging, and age cohort-related differences in the methods used for coping with chronic pain.
SN - 1526-5900
AD - Division of Public Health Service, College of Dentistry, JHM Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610; Jriley@dental.ufl.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Risk Factors Associated With Anabolic-Androgenic Steroid Use Among Adolescents.
AU - Bahrke, M.S.
AU - Yesalis, C.E.
AU - Kopstein, A.N.
AU - Stephens, J.A.
JO - Sports Medicine
JF - Sports Medicine
Y1 - 2000/06//
VL - 29
IS - 6
SP - 397
EP - 405
SN - 01121642
N1 - Accession Number: 9593783; Author: Bahrke, M.S.: 1 Author: Yesalis, C.E.: 2 Author: Kopstein, A.N.: 3 Author: Stephens, J.A.: 2 ; Author Affiliation: 1 Human Kinetics, Champaign, Illinois, USA: 2 Pennsylvania State University, University Park, Pennsylvania, USA: 3 Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20030425
N2 - To identify risk factors associated with anabolic-androgenic steroid (AAS) use among adolescents, computerised and manual literature searches were performed and the resultant local, state, national and international reports of illicit AAS use by adolescents that referenced risk factors were reviewed. Results indicate that adolescent AAS users are significantly more likely to be males and to use other illicit drugs, alcohol and tobacco. Student athletes are also more likely than non-athletes to use AAS, and football players, wrestlers, weightlifters and bodybuilders have significantly higher prevalence rates than students not engaged in these activities. Currently, only a partial profile can be created to characterise the adolescent AAS user. Further research will be needed before associations can be made with a reasonable degree of confidence regarding risk factors such as athletic participation, ethnicity, socioeconomic status and educational level. More importantly, to improve prevention and intervention strategies, a better understanding of the process involved in initiating AAS use is needed, including vulnerability factors, age of initiation and the use of other illicit drugs. ABSTRACT FROM AUTHOR
KW - *ANABOLIC steroids
KW - *TEENAGERS
KW - Adolescents
KW - Anabolic steroids, abuse
KW - Hormonal steroids, abuse
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Flynn, Katherine M.
AU - Ferguson, Sherry A.
AU - Delclos, K. Barry
AU - Newbold, Retha R.
T1 - Effects of Genistein Exposure on Sexually Dimorphic Behaviors in Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/06//
VL - 55
IS - 2
M3 - Article
SP - 311
EP - 319
PB - Oxford University Press / USA
SN - 10966080
AB - The phytoestrogen genistein, the principal isoflavone in soybeans, has adverse effects on animal reproduction. As adult physiology and behavior are sensitive to perturbation by developmental estrogens, exposure to genistein during development may produce behavioral alterations as well. Pregnant rats were fed soy-free diets containing 0, 25, 250, or 1250 ppm genistein (approximately 0, 2, 20, or 100 mg/kg/day) beginning on gestational day 7, and offspring continued on these diets through postnatal day (PND) 77. Male and female offspring were assessed for levels of sexually dimorphic behaviors: open field activity, play behavior, running wheel activity, and consumption of saccharin- and sodium chloride-flavored solutions. Consumption of the salt solution was affected by genistein, with animals in the 1250-ppm group drinking significantly more than controls; consumption of plain water was unaffected. Genistein treatment also significantly affected play behavior; although no treated group was significantly different from controls, and the effect was not sexually dimorphic. Running wheel activity and saccharin solution consumption showed significant sex differences, but no effects of genistein treatment. Gestational duration, total and live pups per litter, and total and live litter sex ratios were not significantly affected by genistein. However, average weight per live pup at birth and offspring body weights from PND 42–77 were significantly decreased in the 1250-ppm group. Body weight and food intake for the dams were also significantly decreased in the 1250-ppm group. These results indicate that developmental genistein treatment, at levels that decrease maternal and offspring body weight, causes subtle alterations in some sexually dimorphic behaviors. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dimorphism in animals
KW - Endocrine disruptors
KW - Phytoestrogens
KW - Rats
KW - Estrogen
KW - Isoflavones
KW - chronic exposure
KW - endocrine disruptor
KW - estrogen
KW - isoflavone
KW - nutrition
KW - phytoestrogen
N1 - Accession Number: 44611681; Flynn, Katherine M. 1; Email Address: kflynn@nctr.fda.gov; Ferguson, Sherry A. 1; Delclos, K. Barry 2; Newbold, Retha R. 3; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; 3: Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: Jun2000, Vol. 55 Issue 2, p311; Thesaurus Term: Dimorphism in animals; Thesaurus Term: Endocrine disruptors; Subject Term: Phytoestrogens; Subject Term: Rats; Subject Term: Estrogen; Subject Term: Isoflavones; Author-Supplied Keyword: chronic exposure; Author-Supplied Keyword: endocrine disruptor; Author-Supplied Keyword: estrogen; Author-Supplied Keyword: isoflavone; Author-Supplied Keyword: nutrition; Author-Supplied Keyword: phytoestrogen; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Woolhiser, Michael R.
AU - Munson, Albert E.
AU - Meade, Jean
T1 - Immunological Responses of Mice following Administration of Natural Rubber Latex Proteins by Different Routes of Exposure.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/06//
VL - 55
IS - 2
M3 - Article
SP - 343
EP - 351
PB - Oxford University Press / USA
SN - 10966080
AB - Although the prevalence of IgE-mediated latex allergy has increased over the past decade, the circumstances which culminate in sensitization remain uncertain. The objective of these studies was to evaluate the role which sensitization route plays in the development of latex allergy using murine models representative of potential exposure routes by which health care workers (topical and respiratory) and spina bifida patients (subcutaneous) may be sensitized. BALB/c mice administered latex proteins by the subcutaneous, topical, intranasal, or intratracheal routes exhibited dose-responsive elevations in total IgE. In vitro splenocyte stimulation initially demonstrated specificity of the murine immune response to latex proteins. Subsequently, immunoblot analysis was used to compare latex-specific IgE production amongst sensitization routes. Immunoblots of IgE from subcutaneously sensitized mice demonstrated recognition of latex proteins with molecular weights near 14 kDa and 27 kDa. These protein sizes are consistent with the molecular weights of major latex allergens (Hev b 1 and Hev b 3), to which high percentages of spina bifida patients develop antibodies. Mice sensitized by intratracheal or topical administration exhibited combined IgE recognition of latex proteins near 14 kDa, 35 kDa, and 92 kDa. These molecular weights are similar to other latex allergens (Hev b 6, Hev b 2, and Hev b 4) commonly recognized by IgE of health care workers. Mice sensitized to latex proteins by topical, intranasal, or intratracheal exposures exhibited bronchoconstriction as evaluated by whole body plethysmography following respiratory challenge with latex proteins. Subcutaneously sensitized mice were unresponsive. These differences in latex-specific IgE immunoblot profiles and altered pulmonary function amongst the four different sensitization routes suggest that exposure routes leading to sensitization may play a role in determining the primary allergen(s), and the clinical manifestation of the allergic responses. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Mice
KW - Latex allergy
KW - Bronchoconstrictor agents
KW - Plethysmography
KW - allergy
KW - bronchoconstriction
KW - Hev B
KW - IgE
KW - latex
KW - mouse
KW - NRL
KW - PENH
KW - plethysmography
KW - respiratory
KW - topical
N1 - Accession Number: 44611707; Woolhiser, Michael R. 1,2; Munson, Albert E. 1; Meade, Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 2: Department of Pharmacology & Toxicology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298; Issue Info: Jun2000, Vol. 55 Issue 2, p343; Thesaurus Term: Immune response; Thesaurus Term: Mice; Subject Term: Latex allergy; Subject Term: Bronchoconstrictor agents; Subject Term: Plethysmography; Author-Supplied Keyword: allergy; Author-Supplied Keyword: bronchoconstriction; Author-Supplied Keyword: Hev B; Author-Supplied Keyword: IgE; Author-Supplied Keyword: latex; Author-Supplied Keyword: mouse; Author-Supplied Keyword: NRL; Author-Supplied Keyword: PENH; Author-Supplied Keyword: plethysmography; Author-Supplied Keyword: respiratory; Author-Supplied Keyword: topical; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kodell, Ralph L.
AU - Lin, Karl K.
AU - Thorn, Brett T.
AU - Chen, James J.
T1 - Bioassays of Shortened Duration for Drugs: Statistical Implications.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/06//
VL - 55
IS - 2
M3 - Article
SP - 415
EP - 432
PB - Oxford University Press / USA
SN - 10966080
AB - Declining survival rates in rodent carcinogenesis bioassays have raised a concern that continuing the practice of terminating such studies at 24 months could result in too few live animals at termination for adequate pathological evaluation. One option for ensuring sufficient numbers of animals at the terminal sacrifice is to shorten the duration of the bioassay, but this approach is accompanied by a reduction in statistical power for detecting carcinogenic potential. The present study was conducted to evaluate the loss of power associated with early termination. Data from drug studies in rats were used to formulate biologically based dose-response models of carcinogenesis using the 2-stage clonal expansion model as a context. These dose-response models, which were chosen to represent 6 variations of the initiation-promotion-completion cancer model, were employed to generate a large number of representative bioassay data sets using Monte Carlo simulation techniques. For a variety of tumor dose-response trends, tumor lethality, and competing risk-survival rates, the power of age-adjusted statistical tests to assess the significance of carcinogenic potential was evaluated at 18 and 21 months, and compared to the power at the normal 24-month stopping time. The results showed that stopping at 18 months would reduce power to an unacceptable level for all 6 submodels of the 2-stage clonal expansion model, with the pure-promoter and pure-completer models being most adversely affected. For the 21-month stopping time, the results showed that, unless pure promotion can be ruled out a priori as a potential carcinogenic mode of action, the loss of power is too great to warrant early stopping. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological assay
KW - Carcinogenesis
KW - Genetic toxicology
KW - TOXICOLOGY
KW - Dose-response relationship (Biochemistry)
KW - Drugs
KW - Monte Carlo method
KW - chronic
KW - dose-response
KW - Food and Drug Administration (FDA)
KW - Monte Carlo
KW - MVK model
KW - power
KW - survival
KW - trend
N1 - Accession Number: 44611698; Kodell, Ralph L. 1; Email Address: rkodell@nctr.fda.gov; Lin, Karl K. 2; Thorn, Brett T. 3; Chen, James J. 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; 2: Division of Biometrics II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857; 3: R.O.W. Sciences, Inc., National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jun2000, Vol. 55 Issue 2, p415; Thesaurus Term: Biological assay; Thesaurus Term: Carcinogenesis; Thesaurus Term: Genetic toxicology; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Dose-response relationship (Biochemistry); Subject Term: Drugs; Subject Term: Monte Carlo method; Author-Supplied Keyword: chronic; Author-Supplied Keyword: dose-response; Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: MVK model; Author-Supplied Keyword: power; Author-Supplied Keyword: survival; Author-Supplied Keyword: trend; Number of Pages: 18p; Illustrations: 9 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2001-00305-008
AN - 2001-00305-008
AU - Riley, Joseph L. III
AU - Wade, James B.
AU - Robinson, Michael E.
AU - Price, Donald D.
T1 - The stages of pain processing across the adult lifespan.
JF - The Journal of Pain
JO - The Journal of Pain
JA - J Pain
Y1 - 2000///Sum 2000
VL - 1
IS - 2
SP - 162
EP - 170
CY - Netherlands
PB - Elsevier Science
SN - 1526-5900
N1 - Accession Number: 2001-00305-008. Partial author list: First Author & Affiliation: Riley, Joseph L. III; Virginia Commonwealth U, Coll of Denistry, Div of Public Health Service & Research, Richmond, VA, US. Release Date: 20010425. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Chronic Pain; Pain Perception. Minor Descriptor: Models. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study. References Available: Y. Page Count: 9. Issue Publication Date: Sum 2000.
AB - Examined age-related differences in a 4-stage model of the processing of chronic pain. This study used data collected from 1,585 chronic pain patients that were divided into 3 age cohorts: younger adults 18–44 years old, middle-aged adults 45–64 years old, older adults 65–85 years old. Using an analysis of covariate analysis model, mean differences across the age cohort were found on the 3rd (emotional distress) and 4th (pain behavior) stages of the pain processing model. The older adult group reported less emotional response to pain and less pain behavior than the younger or middle-aged groups. Age cohort differences in the linear relationship between stages were tested using structural equation modeling. The middle-aged group showed the highest association between their emotional responses to pain and pain behaviors, and the older group showed the least association. No differences in magnitude or association were found for the 2 initial stages of pain processing (usual pain intensity or pain unpleasantness). A correction concerning this article appears in Vol (3) of Journal of Pain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - age
KW - 4 stage model chronic pain processing
KW - 18–85 yr olds
KW - 2000
KW - Age Differences
KW - Chronic Pain
KW - Pain Perception
KW - Models
KW - 2000
DO - 10.1016/S1526-5900(00)90101-9
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107000957
T1 - Making medical devices safer.
AU - Kingsley P
AU - Sawyer D
AU - Carstensen P
Y1 - 2000/06/12/2000 Jun 12
N1 - Accession Number: 107000957. Language: English. Entry Date: 20010223. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Nursing; USA. NLM UID: 9892047.
KW - Consumer Product Safety
KW - Product Surveillance
SP - 6
EP - 7
JO - Nursing Spectrum -- New England Edition
JF - Nursing Spectrum -- New England Edition
JA - NURS SPECTRUM (N ENGL)
VL - 4
IS - 12
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
AD - Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107129687
T1 - Work related deaths in West Virginia: targeting research and prevention efforts.
AU - Higgins DN
AU - Helmkamp JC
AU - Williams JM
AU - King ME
Y1 - 2000/07//2000 Jul
N1 - Accession Number: 107129687. Language: English. Entry Date: 20000901. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Grant Information: Supported by Cooperative Aggreement U60/CCU312914-02 from the Centers for Disease Control and Prevention (CDC). NLM UID: 8608669.
KW - Occupational-Related Injuries -- Mortality -- West Virginia
KW - Occupational-Related Injuries -- Prevention and Control
KW - Disease Surveillance
KW - Mortality -- Etiology
KW - Occupational Safety
KW - Funding Source
KW - West Virginia
KW - Epidemiological Research
KW - Occupational Health Nursing
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
SP - 331
EP - 337
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 48
IS - 7
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - The primary goal of the Fatality Assessment and Control Evaluation (FACE) research program is to prevent work related deaths by identifying work situations causing high risk for fatal injury, formulating prevention strategies, and disseminating information to those who can intervene in the workplace. The National Institute for Occupational Safety and Health has cooperative agreements with 15 states to conduct fatality research using the FACE protocol. From the West Virginia FACE data for the 18 month period from July 1996 to December 1997, it was revealed that West Virginia has the fifth highest rate for work related death in the nation. Eighty-three workers died during the period and four external causes-motor vehicle crashes, machine related, falls, and struck by falling objects-accounted for nearly two thirds of these deaths. Occupational health nurses work in the FACE research program as field investigators and principal investigators. Other occupational and environmental health nurses are in a vital position to disseminate FACE research findings.
SN - 0891-0162
AD - Safety and Occupational Health Specialist, Trauma Investigations Section, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 11261182.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Huba, G.J.
AU - Melchior, Lisa A.
AU - Woods, Elizabeth R.
AU - Panter, A.T.
AU - Feudo, Rudy
AU - Schneir, Arlene
AU - Trevithick, Lee
AU - Wright, Eric
AU - Martinez, Ramon
AU - Sturdevant, Marsha
AU - Remafedi, Gary
AU - Greenberg, Brian
AU - Tierney, Steven
AU - Wallace, Michael
AU - Goodman, Elizabeth
AU - Tenner, Adam
AU - Marconi, Katherine
AU - Brady, Russell E.
AU - Singer, Barney
T1 - Service Use Patterns of Youth with, and at High Risk for, HIV: A Care Typology.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2000/07//
VL - 14
IS - 7
M3 - Article
SP - 359
EP - 379
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - This paper uses confirmatory structural equation models to develop and test a theoretical model for understanding the service utilization history of 4679 youth who received services from 10 national HIV/AIDS demonstration models of youth-appropriate and youth-attractive services funded by the Special Projects of National Significance (SPNS) Program, HIV/AIDS Bureau, Health Resources and Services Administration. Although the projects differ from one another in the areas of emphasis in their service models, each is targeted to youth at high risk for HIV, or those youth who have already contracted HIV. Collectively, the projects represent a comprehensive adoelscent HIV service model. This paper examines the characteristics of the services provided to young people ranging from outreach to intensive participation in medical treatment. Major typologies of service utilization are derived empirically through exploratory factor and cluster analysis methods. Confirmatory structural equation modeling methods are used to refine the exploratory results using a derivation and replication strategy and methods of statistical estimation appropriate for non-normally distributed service utilization indicators. The model hypothesizes that youth enter the service system through a general construct of connectedness to a comprehensive service model and through service-specific methods, primarily of outreach or emergency services. Estimates are made of the degree to which a comprehensive service model drives the services as opposed to specific service entry points. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - Youth -- United States
KW - United States
N1 - Accession Number: 3422208; Huba, G.J. 1; Melchior, Lisa A. 1; Woods, Elizabeth R. 2; Panter, A.T. 3; Feudo, Rudy 4; Schneir, Arlene 5; Trevithick, Lee 6; Wright, Eric 7; Martinez, Ramon 8; Sturdevant, Marsha 9; Remafedi, Gary 10; Greenberg, Brian 11; Tierney, Steven 12; Wallace, Michael 13; Goodman, Elizabeth 2; Tenner, Adam 6; Marconi, Katherine 14; Brady, Russell E. 14; Singer, Barney 14; Affiliations: 1: The Measurement Group, Culver City, California; 2: Children's Hospital of Boston, Boston, Massachusetts; 3: University of North Carolina, Chapel Hill; 4: Greater Bridgeport Adolescent Pregnancy Project, Bridgeport, Connecticut; 5: Children's Hospital Los Angeles, Los Angeles, California; 6: YouthCare, Seattle, Washington; 7: Indiana University Purdue University Indianapolis, Indiana; 8: Bay Area Young Positives, San Francisco, California; 9: University of Alabama, Birmingham; 10: University of Minnesota Youth and AIDS Project, Minneapolis; 11: Walden House, San Francisco, California; 12: Health Initiatives for Youth, San Francisco, California; 13: Indiana State Department of Health, Indianapolis, Indiana; 14: Health Resources and Services Administration, Rockville, Maryland; Issue Info: Jul2000, Vol. 14 Issue 7, p359; Subject Term: HIV-positive persons -- Medical care; Subject Term: Youth -- United States; Subject: United States; Number of Pages: 21p; Illustrations: 1 Diagram, 9 Charts, 1 Graph; Document Type: Article
L3 - 10.1089/108729100413239
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Marcus, Marvin
AU - Freed, James R.
AU - Coulter, Ian D.
AU - Der-Martirosian, Claudia
AU - William Cunningham
AU - Andersen, Ronald
AU - Garcia, Isabel
AU - Schneider, Donald A.
AU - Maas, William R.
AU - Bozzette, Samuel A.
AU - Shapiro, Martin F.
T1 - Perceived Unmet Need for Oral Treatment Among a National Population of HIV-Positive Medical Patients: Social and Clinical Correlates.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/07//
VL - 90
IS - 7
M3 - Article
SP - 1059
EP - 1063
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examines social. behavioral, and clinical correlates of perceived unmet need for oral health care for people with HIV infection. Methods. Baseline in-person interviews with 2864 individuals were conducted with the HIV Cost and Services Utilization Study cohort, a nationally representative probability sample of HIV-infected persons in medical care. Bivariate and logistic regression analyses were conducted, with unmet need in the last 6 months as the dependent variable and demographic, social, behavioral, and disease characteristics as independent variables. Results. We estimate that 19.3% of HIV-infected medical patients (n = 44550) had a perceived unmet need for dental care in the last 6 months. The odds of having unmet dental needs were highest for those on Medicaid in states without dental benefits (odds ratio [OR]=2.21), for others with no dental insurance (OR=2.26), for those with incomes under $5000 (OR=2.20), and for those with less than a high school education (OR=1.83). Low CD4 count was not significant. Conclusions. Perceived unmet need was related more to social and economic factors than to stage of infection. An expansion of dental benefits for those on Medicaid might reduce unmet need for dental care. (Am J Public Health. 2000;90:1059-1063) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Demography
KW - HIV infections
KW - Medical care
KW - Patients
KW - Medicare
KW - Interpersonal relations
N1 - Accession Number: 3270044; Marcus, Marvin 1,2; Email Address: mamarcus@ucla.edu; Freed, James R. 1; Coulter, Ian D. 1,3; Der-Martirosian, Claudia 1; William Cunningham 4; Andersen, Ronald 5; Garcia, Isabel 6; Schneider, Donald A. 7; Maas, William R. 8; Bozzette, Samuel A. 3,9; Shapiro, Martin F. 3,4; Affiliations: 1: School of Dentistry, University of California at Los Angeles.; 2: Chair, HCSUS Oral Health Team.; 3: RAND, Santa Monica, Calif.; 4: School of Medicine, University of California at Los Angeles.; 5: School of Public Health, University of California at Los Angeles.; 6: National Institute of Dental and Craniofacial Research, Bethesda, Md.; 7: Health Care Financing Administration, Baltimore, Md.; 8: Agency for Healthcare Research and Quality, Atlanta, Ga.; 9: School of Medicine, University of California at San Diego.; Issue Info: Jul2000, Vol. 90 Issue 7, p1059; Thesaurus Term: Demography; Subject Term: HIV infections; Subject Term: Medical care; Subject Term: Patients; Subject Term: Medicare; Subject Term: Interpersonal relations; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Pengfei Gao
AU - Chen, Bean T.
AU - Hearl, Frank J.
AU - McCawley, Michael A.
AU - Schwerha, Diana J.
AU - Odencrantz, John
AU - Weihong Chen
AU - Jingqiong Chen
AU - Soderholm, Sidney C.
T1 - Estimating Factors to Convert Chinese ‘Total Dust’ Measurements to ACGIH Respirable Concentrations in Metal Mines and Pottery Industries.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2000/07//
VL - 44
IS - 4
M3 - Article
SP - 251
EP - 257
SN - 00034878
AB - Historical data on the dust exposures of Chinese workers in metal mines (iron/copper, tin, tungsten) and pottery industries are being used in an ongoing joint Chinese/United States epidemiological study to investigate the exposure–response relationship for the development of silicosis, lung cancer, and other diseases. The historical data include ‘total dust’ concentrations determined by a Chinese method. Information about particle size distribution and the chemical and mineralogical content of airborne particles is generally not available. In addition, the historical Chinese sampling strategy is different from a typical American eight-hour time-weighted average (TWA) sampling strategy, because the Chinese samples were collected for approximately 15 minutes during production so the sample could be compared to their maximum allowable concentration (MAC) standard. Therefore, in order to assess American respirable dust exposure standards in light of the Chinese experience, factors are needed to convert historical Chinese total dust concentrations to respirable dust concentrations. As a part of the joint study to estimate the conversion factors, airborne dust samples were collected in 20 metal mines and 9 pottery factories in China during 1988 and 1989 using three different samplers: 10mm nylon cyclones, multi-stage ‘cassette’ impactors, and the traditional Chinese total dust samplers. More than 100 samples were collected and analysed for each of the three samplers. The study yielded two different estimates of the conversion factor from the Chinese total dust concentrations (measured during production processes) to respirable dust concentrations. The multivariate analysis of variance (MANOVA) reveals that, with a fixed sampling/analysis method, conversion factors were not statistically different among the different job titles within each industry. It also indicates that conversion factors among the industries were not statistically different. However, the two estimates consistently showed that conversion factors were the lowest in the pottery industry. Average conversion factors were then calculated for each of the estimates across the industries studied. A pooled mean conversion factor, 0.25±0.04, was then derived for all the job titles and industries. Respirable dust levels were estimated from the historical ‘total dust’ concentrations collected between 1952 and 1992 by adopting the American standard. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial toxicology
KW - Effect of environment on human beings
KW - Mines & mineral resources
KW - Epidemiology -- Research
KW - Pottery industry
KW - Silicosis
KW - Lungs -- Cancer
KW - Multivariate analysis
KW - Dust -- Environmental aspects
KW - ACGIH definition
KW - conversion factor
KW - copper
KW - exposure estimates
KW - iron
KW - metal mines
KW - mining dust
KW - pottery
KW - respirable dust
KW - tin
KW - tungsten
N1 - Accession Number: 44400063; Pengfei Gao 1; Email Address: pcg9@cdc.gov; Chen, Bean T. 1; Hearl, Frank J. 1; McCawley, Michael A. 1; Schwerha, Diana J. 1; Odencrantz, John 1; Weihong Chen 2; Jingqiong Chen 2; Soderholm, Sidney C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Department of Labor Health and Occupational Diseases, Tongji Medical University,13 Hangkong Road, Wuhan, Hubei, People's Republic of China; Issue Info: Jul2000, Vol. 44 Issue 4, p251; Thesaurus Term: Industrial toxicology; Thesaurus Term: Effect of environment on human beings; Thesaurus Term: Mines & mineral resources; Thesaurus Term: Epidemiology -- Research; Subject Term: Pottery industry; Subject Term: Silicosis; Subject Term: Lungs -- Cancer; Subject Term: Multivariate analysis; Subject Term: Dust -- Environmental aspects; Author-Supplied Keyword: ACGIH definition; Author-Supplied Keyword: conversion factor; Author-Supplied Keyword: copper; Author-Supplied Keyword: exposure estimates; Author-Supplied Keyword: iron; Author-Supplied Keyword: metal mines; Author-Supplied Keyword: mining dust; Author-Supplied Keyword: pottery; Author-Supplied Keyword: respirable dust; Author-Supplied Keyword: tin; Author-Supplied Keyword: tungsten; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 442298 All other home furnishings stores; NAICS/Industry Codes: 414310 China, glassware, crockery and pottery merchant wholesalers; NAICS/Industry Codes: 327110 Pottery, Ceramics, and Plumbing Fixture Manufacturing; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Devers, Kelly J.
AU - Frankel, Richard M.
T1 - Study Design in Qualitative Research—2: Sampling and Data Collection Strategies.
JO - Education for Health: Change in Learning & Practice (Taylor & Francis Ltd)
JF - Education for Health: Change in Learning & Practice (Taylor & Francis Ltd)
Y1 - 2000/07//
VL - 13
IS - 2
M3 - Article
SP - 263
EP - 271
PB - Taylor & Francis Ltd
SN - 13576283
AB - In two prior papers in our series on qualitative research [Frankel & Devers (2000a, 2000b) Qualitative research: a consumer's guide, Education for Health, 13, 113-123; Frankel & Devers (2000) Study design in qualitative research-1: developing research questions and assessing research needs, Education for Health, 13, 251-261], we examine two critical issues in qualitative research design: sampling, including identifying and negotiating access to research sites and subjects, and data collection and management. We describe these two key steps in the qualitative research design process, discuss challenges that often emerge when pursuing these steps, and provide guidelines for addressing them. Qualitative research most often uses "purposive," rather than random, sampling strategies. A good understanding of these sampling strategies and why they are used is central to designing a credible qualitative study. In addition, given the real-world context in which most qualitative research is carried out, identifying and negotiating access to research sites and subjects are critical parts of the process. We also provide suggestions for developing and maintaining productive and mutually satisfying research relationships with sites and subjects. Finally, data collection and management are often neglected subjects in qualitative research. We offer practical advice on how to collect and manage qualitative data, including factors to consider when deciding how structured the data collection process should be, the pros and cons of audio- and/or videotaping compared with note-taking, and tips for writing up field notes and document management. A forthcoming, final paper in the series will focus on qualitative data analysis and the publication of qualitative research results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Education for Health: Change in Learning & Practice (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITATIVE research
KW - COMPUTERS in research
N1 - Accession Number: 3635418; Devers, Kelly J. 1; Frankel, Richard M. 2; Source Information: Jul2000, Vol. 13 Issue 2, p263; Subject: QUALITATIVE research; Subject: COMPUTERS in research; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 3715
L3 - 10.1080/13576280050074543
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Verthelyi, D.
AU - Klinman, D. M.
T1 - Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo.
JO - Immunology
JF - Immunology
Y1 - 2000/07//
VL - 100
IS - 3
M3 - Article
SP - 384
EP - 390
SN - 00192805
AB - Summary This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-α (TNF-α) or interferon-γ (IFN-γ) in vivo. Simultaneous assessment of serum hormone levels and cytokine-secreting cell activity throughout the menstrual cycle showed that the number of peripheral blood mononuclear cells (PBMC) able to secrete IL-4 in response to stimulation correlated significantly (P < 0·0001) with oestrogen levels and fluctuated with the menstrual cycle in pre-menopausal women. The activity of IFN-γ-secreting cells, on the other hand, varied as a function of serum DHEA-S levels in pre-menopausal women (P < 0·0001). Similarly, the number of cells secreting IFN-γ in men correlated with serum DHEA-S levels (P < 0·001). In contrast, post-menopausal women had fewer cells actively secreting cytokines and the activity of these cells did not correlate with sex hormone levels. These results suggest that sex hormones may modulate cytokine production in vivo and contribute to gender-related differences in normal and pathological immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX hormones
KW - SERUM
KW - ESTROGEN
KW - PROGESTERONE
KW - DEHYDROEPIANDROSTERONE
N1 - Accession Number: 5464891; Verthelyi, D. 1; Klinman, D. M. 1; Source Information: Jul2000, Vol. 100 Issue 3, p384; Subject: SEX hormones; Subject: SERUM; Subject: ESTROGEN; Subject: PROGESTERONE; Subject: DEHYDROEPIANDROSTERONE; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107144149
T1 - From the Food and Drug Administration. Recall of Clinipad sterile products used in prepackaged procedure kits and trays.
AU - Feigel DW Jr.
Y1 - 2000/07//2000 Jul-Sep
N1 - Accession Number: 107144149. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Product Recall
KW - Surgical Equipment and Supplies
KW - Equipment Contamination
SP - 101
EP - 102
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 6
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Director, Center for Devices and Radiological Health, Food and Drug Administration, Rockville
U2 - PMID: 10891849.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 89449714
T1 - Activity of thalidomide in AIDS-related Kaposi's sarcoma.
AU - Little, Richard F.
AU - Wyvill, Kathleen M.
AU - Pluda, James M.
AU - Welles, Lauri
AU - Marshall, Vickie
AU - Figg, William D.
AU - Newcomb, Fonda M.
AU - Tosato, Giovanna
AU - Feigal, Ellen
AU - Steinberg, Seth M.
AU - Whitby, Denise
AU - Goedert, James J.
AU - Yarchoan, Robert
AU - Little, R F
AU - Wyvill, K M
AU - Pluda, J M
AU - Welles, L
AU - Marshall, V
AU - Figg, W D
AU - Newcomb, F M
Y1 - 2000/07//7/1/2000
N1 - Accession Number: 89449714. Language: English. Entry Date: 20001001. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Acquired Immunodeficiency Syndrome -- Complications
KW - Anti-HIV Agents -- Therapeutic Use
KW - Sarcoma, Kaposi's -- Drug Therapy
KW - Thalidomide -- Therapeutic Use
KW - Male
KW - Anti-HIV Agents -- Adverse Effects
KW - Human
KW - Thalidomide -- Administration and Dosage
KW - Administration, Oral
KW - Anti-HIV Agents -- Administration and Dosage
KW - Adult
KW - Disease Progression
KW - Sarcoma, Kaposi's -- Pathology
KW - Sarcoma, Kaposi's -- Complications
KW - Thalidomide -- Adverse Effects
KW - Middle Age
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 2593
EP - 2602
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 18
IS - 13
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: To assess the toxicity and activity of oral thalidomide in Kaposi's sarcoma (KS) in a phase II dose-escalation study.Patients and Methods: Human immunodeficiency virus (HIV)-seropositive patients with biopsy-confirmed KS that progressed over the 2 months before enrollment received an initial dose of 200 mg/d of oral thalidomide in a phase II study. The dose was increased to a maximum of 1,000 mg/d for up to 1 year. Anti-HIV therapy was maintained during the study period. Toxicity, tumor response, immunologic and angiogenic factors, and virologic parameters were assessed.Results: Twenty patients aged 29 to 49 years with a median CD4 count of 246 cells/mm(3) (range, 14 to 646 cells/mm(3)) were enrolled. All patients were assessable for toxicity, and 17 for response. Drowsiness in nine and depression in seven patients were the most frequent toxicities observed. Eight (47%; 95% confidence interval [CI], 23% to 72%) of the 17 assessable patients achieved a partial response, and an additional two patients had stable disease. Based on all 20 patients treated, the response rate was 40% (95% CI, 19% to 64%). The median thalidomide dose at the time of response was 500 mg/d (range, 400 to 1,000 mg/d). The median duration of drug treatment was 6.3 months, and the median time to progression was 7.3 months.Conclusion: Oral thalidomide was tolerated in this population at doses up to 1,000 mg/d for as long as 12 months and was found to induce clinically meaningful anti-KS responses in a sizable subset of the patients. Additional studies of this agent in KS are warranted.
SN - 0732-183X
AD - HIV and AIDS Malignancy Branch, Medicine Branch, National Cancer Institute
AD - Biostatistics and Data Management Section, Division of Clinical Sciences, National Cancer Institute
AD - Division of Cancer Treatment and Diagnosis, National Cancer Institute
AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
AD - Division of Hematologic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda
AD - Science Applications International Corporation, Frederick, MD
AD - HIV and AIDS Malignancy Branch, Medicine Branch, and Biostatistics and Data Management Section, Division of Clinical Sciences, Frederick, MD, USA
U2 - PMID: 10893291.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107125860
T1 - Device safety. Warming up to safe infusions.
AU - Morrison A
Y1 - 2000/07//
N1 - Accession Number: 107125860. Language: English. Entry Date: 20100108. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Blood Transfusion
KW - Warming Techniques -- Adverse Effects
KW - Embolism, Air -- Etiology
KW - Blood
KW - Gases
SP - 78
EP - 78
JO - Nursing
JF - Nursing
JA - NURSING
VL - 30
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 10983109.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, Geoffrey W.
AU - Constable, Peter D.
AU - Eppley, Robert M.
AU - Tumbleson, Mike E.
AU - Gumprecht, Laura A.
AU - Haschek-Hock, Wanda M.
T1 - Purified Fumonisin B1 Decreases Cardiovascular Function but Does Not Alter Pulmonary Capillary Permeability in Swine.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/07//
VL - 56
IS - 1
M3 - Article
SP - 240
EP - 249
PB - Oxford University Press / USA
SN - 10966080
AB - Fumonisins are mycotoxins produced by Fusarium verticillioides, which induce acute pulmonary edema in swine. We previously reported that ingestion of fumonisin-containing culture material decreases cardiovascular function in swine (1996,a,b; Fundam. Appl. Toxicol. 31, 169–172; 33, 140–148; 1999, Am. J Vet. Res. 60, 1291–1300). The main purpose of this study was to confirm that fumonisin B1 was responsible for the observed cardiovascular changes. Treated pigs (n = 6) were given daily intravenous injections of purified fumonisin B1 at 1 mg/kg for 4 days, while controls (n = 6) were injected with equal volumes of saline. On day 5, pigs were anesthetized with butorphanol-chloralose and instrumented for hemodynamic studies. Terminally, bronchoalveolar lavage was performed on each pig to determine the relative permeability index of the pulmonary endothelium. Fumonisin B1-treated pigs had marked decreases in the maximal rate of change of left ventricular pressure (dP/dtmax), mean aortic pressure, cardiac output, and arterial pO2, accompanied by increases in mean pulmonary artery pressure, oxygen extraction ratio, and blood hemoglobin concentration. Plasma and left ventricular sphingosine and sphinganine concentrations were markedly increased in treated pigs at day 5; however, there was no difference in the relative permeability index between groups. Serum cholesterol concentrations and activities of hepatic-derived enzymes were increased, and hepatocyte apoptosis and mitoses were present in the livers of fumonisin-treated pigs. In the lungs of treated pigs, there was proteinaceous edema and membranous accumulations in capillary endothelial cells. These results indicate that cardiovascular function is altered by fumonisin B1, and that fumonisin-induced pulmonary edema is caused by left-sided heart failure and not by altered endothelial permeability. Because of the potential for contamination of human foodstuffs by fumonisins, the cardiovascular toxicity of these compounds must be taken into consideration. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycotoxins
KW - Permeability
KW - Swine -- Diseases
KW - Fumonisins
KW - Fusarium
KW - Pulmonary edema
KW - Lung diseases
KW - Heart failure
KW - cardiovascular
KW - fumonisin
KW - heart failure
KW - pulmonary edema
KW - swine
N1 - Accession Number: 44611714; Smith, Geoffrey W. 1,2; Email Address: gw-smith@uiuc.edu; Constable, Peter D. 1,2; Eppley, Robert M. 3; Tumbleson, Mike E. 4; Gumprecht, Laura A. 2; Haschek-Hock, Wanda M. 2; Affiliations: 1: Departments of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 2: Departments of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland 20708; 4: Departments of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; Issue Info: Jul2000, Vol. 56 Issue 1, p240; Thesaurus Term: Mycotoxins; Thesaurus Term: Permeability; Thesaurus Term: Swine -- Diseases; Subject Term: Fumonisins; Subject Term: Fusarium; Subject Term: Pulmonary edema; Subject Term: Lung diseases; Subject Term: Heart failure; Author-Supplied Keyword: cardiovascular; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: heart failure; Author-Supplied Keyword: pulmonary edema; Author-Supplied Keyword: swine; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lucas, Anne D.
AU - Tomazic-Jezic, Vesna J.
T1 - MODIFICATION OF THE LOWRY METHOD FOR ANALYSIS OF SOLUBLE LATEX PROTEINS.
JO - Toxicology Methods
JF - Toxicology Methods
Y1 - 2000/07//
VL - 10
IS - 3
M3 - Article
SP - 165
EP - 179
PB - Taylor & Francis Ltd
SN - 10517235
AB - Proteins from natura lrubber latex (NRL) can cause local and systemic reactions in people who are allergic to it. Reducing the total protein in NRL products to minimize the allergenic potential requires methods of accurately estimating the amount of protein. Previous work in this laboratory and others has indicated that, of the colorimetric assays, a modified Lowry method performs best. The American Society for Testing Materials (ASTM) has adopted the modified Lowry method for analysis of soluble NRL proteins.This method, although the best currently available, lacks sufficient reproducibility and sensitivity. In anattempt to improve the method, we address in this article the importance of various extraction conditions and additional approaches to eliminate interfering substances that may cause the false-positive values in the test. Depending on the chemical composition of the accelerants added during manufacturing processes, different means may be employed to remove or to account for the presence of these small organic molecules. The best general way to remove these chemical compounds is the partitioning of the latex extracts with ethyl acetate followed by acid precipitation. Although there is no one perfect method for all NRL proteins and products, the data presented here indicate that changes in the standard protocol of the Lowry method may result in more reproducible and reliable results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - PROTEINS
KW - ALLERGY
KW - Allergens
KW - LOWRY METHOD
KW - Natural rubber latex proteins
KW - protein quantitation
N1 - Accession Number: 3847652; Lucas, Anne D. 1; Tomazic-Jezic, Vesna J. 1; Source Information: Jul2000, Vol. 10 Issue 3, p165; Subject: LATEX; Subject: PROTEINS; Subject: ALLERGY; Author-Supplied Keyword: Allergens; Author-Supplied Keyword: LOWRY METHOD; Author-Supplied Keyword: Natural rubber latex proteins; Author-Supplied Keyword: protein quantitation; Number of Pages: 15p; Illustrations: 6 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10517230050121589
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Snawder, J.E.
AU - Savage Jr, R. E.
T1 - CHARACTERIZATION OF CYTOCHROME P450-DEPENDENT AND GLUTATHIONE TRANSFERASE ACTIVITIES IN SV40-IMMORTALIZED UROEPITHELIAL CELL LINES: POSSIBLE ROLE IN TRANSFORMATION AND TUMOR FORMATION.
JO - Toxicology Methods
JF - Toxicology Methods
Y1 - 2000/07//
VL - 10
IS - 3
M3 - Article
SP - 195
EP - 201
PB - Taylor & Francis Ltd
SN - 10517235
AB - An in vitro/in vivo transformation system has been developed as a model for bladder tumorigenesis. SV40-immortalized human uroepithelial cells are exposed to putative carcinogens and then implanted into athymic nude mice to testfortumorigenesis.Studieswith4-aminobiphenyl(4-ABP)demonstratedthat one cell line, SV-HUC-PC, was sensitive to chemical-induced transformation and another line, SV-HUC-BC, was refractory.Weare currently testing this system as a model to identify occupational carcinogens and develop biomarkers of exposure and effects of exposure. As part of this study, we examined P450- dependent metabolism, glutathione transferase, and the effects of chemicals on deoxyribonucleic acid(DNA)synthesisandrepair inSV-HUC-PC andSV-HUCBC. Activities for CYP1A1/1A2, CYP3A, and CYP2B1/2B2 were estimated by determining o -dealkylation of ethoxy-, benzoxy-, and pentoxy-resorufin, respectively. Coumarin hydroxylase and p -nitrophenol hydroxylase were used to estimate CYP2A and CYP2E1, respectively. SV-HUC-PC microsomes had fivefold greaterCYP1A1/1A2activityandtwofoldhigherCYP3AactivitythanSV-HUCBC. CYP2B1/2B2 and CYP2A activities and glutathione transferase were not different between the two cell lines. DNA synthesis and repair, by BrdU incorporation, was not different between the two lines when N-methyl-N-nitroN-nitrosoguanidine (MNNG) or other reactive metabolites were tested; however, SV-HUC-PC was more sensitive to n -nitrosodimethylamine, 4-ABP, and 4,4-methylene bis (2-chloroaniline) (MOCA). The data demonstrate that, while these cells have retained form-specific P450 activities, SV-HUC-PC has greater CYP1A1/1A2 and CYP3A activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - GLUTATHIONE transferase
KW - CELL lines
KW - Glutathione transferase
N1 - Accession Number: 3847650; Snawder, J.E. 1; Savage Jr, R. E. 1; Source Information: Jul2000, Vol. 10 Issue 3, p195; Subject: CYTOCHROME P-450; Subject: GLUTATHIONE transferase; Subject: CELL lines; Author-Supplied Keyword: Glutathione transferase; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/10517230050121606
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107136521
T1 - Quality and outcomes of care for older women with chronic disease.
AU - Clancy CM
AU - Bierman AS
AU - Maroney CL
Y1 - 2000/07//2000 Jul-Aug
N1 - Accession Number: 107136521. Language: English. Entry Date: 20001001. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Outcomes (Health Care)
KW - Quality of Health Care -- In Old Age
KW - Gerontologic Care
KW - Chronic Disease -- In Old Age
KW - Women's Health Services -- In Old Age
KW - Aged
KW - Female
SP - 178
EP - 191
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 10
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 10899665.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107007133
T1 - Oral montelukast was better than inhaled salmeterol for reducing exercise-induced bronchoconstriction in adults with asthma...commentary on Edelman JM, Turpin JA, Bronsky EA et al., for the Exercise Study Group. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction: a randomized, double-blind trial. ANN INTERN MED 2000 Jan 18;132:97-104
AU - Honig PK
Y1 - 2000/07/04/
N1 - Accession Number: 107007133. Language: English. Entry Date: 20010316. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Montelukast -- Administration and Dosage
KW - Salmeterol -- Administration and Dosage
KW - Asthma, Exercise-Induced -- Prevention and Control
KW - Asthma, Exercise-Induced -- Physiopathology
KW - Clinical Trials
KW - Random Assignment
KW - Administration, Oral
KW - Administration, Inhalation
KW - Descriptive Statistics
KW - P-Value
KW - Forced Expiratory Volume
KW - Treatment Outcomes
KW - Age Factors
KW - Sex Factors
KW - Male
KW - Female
KW - Adolescence
KW - Adult
KW - Middle Age
KW - United States
SP - 3
EP - 3
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 133
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Food and Drug Administration, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107018900
T1 - Trends in twin birth outcomes and prenatal care utilization in the United States, 1981-1997.
AU - Kogan MD
AU - Alexander GR
AU - Kotelchuck M
AU - MacDorman MF
AU - Buekens P
AU - Martin JA
AU - Papiernik E
AU - Kogan, M D
AU - Alexander, G R
AU - Kotelchuck, M
AU - MacDorman, M F
AU - Buekens, P
AU - Martin, J A
AU - Papiernik, E
Y1 - 2000/07/19/
N1 - Accession Number: 107018900. Language: English. Entry Date: 20010427. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: MCJ-9040//PHS HHS/United States. NLM UID: 7501160.
KW - Pregnancy Outcomes -- Trends -- United States
KW - Twins
KW - Prenatal Care -- Utilization -- United States
KW - United States
KW - Odds Ratio
KW - Confidence Intervals
KW - Infant, Newborn
KW - Pregnancy
KW - Female
KW - Funding Source
KW - Human
SP - 335
EP - 341
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 284
IS - 3
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Multiple births account for an increasing percentage of all low-birth-weight infants, preterm births, and infant mortality in the United States. Since 1981, the percentage of women with multiple births who received intensive prenatal care (defined as a high number of visits, exceeding the recommendation of the American College of Obstetricians and Gynecologists by approximately 1 SD beyond the mean number of visits for women initiating care within each trimester) has increased significantly.Objectives: To explore the hypothesis that more aggressive management of twin-birth pregnancies may be associated with changes in birth outcomes in this population.Design, Setting, and Subjects: Cross-sectional and trend analysis of data from the National Center for Health Statistics' birth and infant death records for all twin births occurring in the United States between 1981 and 1997, excluding those with missing or inconsistent data.Main Outcome Measures: Trends in preterm birth, low birth weight, preterm and term small-for-gestational-age (SGA) births, and infant mortality, by level of prenatal care utilization.Results: The preterm birth rate for twins increased from 40.9% in 1981 to 55.0% in 1997. The percentage of low-birth-weight infants increased from 51.0% to 54.0%. The preterm SGA rate also increased from 11.9% to 14.1%, while the term SGA rate decreased from 30.7% to 20.5%. For women with intensive prenatal care utilization, the preterm birth rate increased from 35.1% to 55.8%, compared with an increase from 50.6% to 59.2% among women with only adequate use. Twin preterm deliveries involving either induction or first cesarean delivery also increased from 21.9% to 27.3% between 1989-1991 and 1995-1997. The twin infant mortality rate for women with intensive prenatal care use declined between 1983 and 1996 and remained lower than the overall twin infant mortality rate.Conclusions: An apparent increase in medical interventions in the management of twins may result in the seeming incongruity of more prenatal care and more preterm births; however, these data suggest that women with intensive prenatal care utilization also have a lower infant mortality rate. JAMA. 2000;283:335-341
SN - 0098-7484
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Ln, Room 18A-55, Rockville, MD 20857, USA
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Ln, Room 18A-55, Rockville, MD 20857; mkogan@hrsa.gov
U2 - PMID: 10891965.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Koller, Elizabeth
AU - Mann, Marianne
AU - Malozowski, Saul
AU - Bacsanyi, Janos
AU - Gibert, Cynthia
T1 - Aseptic Necrosis in HIV Seropositive Patients: A Possible Etiologic Role for Megestrol Acetate.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2000/08//
VL - 14
IS - 8
M3 - Article
SP - 405
EP - 410
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - The association between pharmacologic doses of corticosteroids and the development of aseptic bone necrosis has been well documented. Recent reports have described the corticosteroid activity of megestrol acetate. A retrospective review of adverse events reported to the U.S. Food and Drug Administration identified three human immunodeficiency virus (HIV) seropositive patients who developed avascular necrosis of the femoral head during treatment with megestrol acetate. All were males, ages 34, 36, and 55 years, and were on therapy for 6, 1.5, and 18 months, respectively, when symptoms of aseptic necrosis occurred in the absence of antecedent trauma. Megestrol acetate doses were 640, 320, and 600–1200 mg/d, respectively. Two patients had no history of corticosteroid use whereas the third had taken an undisclosed dose and duration of corticosteroids concurrent with pentamidine administration. Notably, despite the predominant use of megestrol in women for hormone sensitive malignancies, none of the reports of aseptic necrosis occurred in this population. Megestrol acetate may be associated with the development of avascular necrosis via its glucocorticoid-like effects. Cachectic acquired immunodeficiency syndrome (AIDS) patients may have additional risk factors that predispose them to aseptic necrosis when receiving megestrol acetate. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - HIV infections -- Complications
KW - Bones -- Necrosis
KW - HIV-positive persons
KW - Adrenocortical hormones
KW - Drugs -- Side effects
N1 - Accession Number: 3535187; Koller, Elizabeth 1; Mann, Marianne 1; Malozowski, Saul 1; Bacsanyi, Janos 1; Gibert, Cynthia 2; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 2: Department of Infectious Disease, Veteran's Administration Medical Center, Washington, D.C.; Issue Info: Aug2000, Vol. 14 Issue 8, p405; Thesaurus Term: DISEASES; Subject Term: HIV infections -- Complications; Subject Term: Bones -- Necrosis; Subject Term: HIV-positive persons; Subject Term: Adrenocortical hormones; Subject Term: Drugs -- Side effects; Number of Pages: 6p; Illustrations: 4 Black and White Photographs, 1 Chart; Document Type: Article
L3 - 10.1089/108729100416614
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DB - eih
ER -
TY - JOUR
ID - 106987844
T1 - Aseptic necrosis in HIV seropositive patients: a possible etiologic role for megestrol acetate.
AU - Koller E
AU - Mann M
AU - Malozowski S
AU - Bacsanyi J
AU - Gibert C
Y1 - 2000/08//
N1 - Accession Number: 106987844. Language: English. Entry Date: 20010105. Revision Date: 20150818. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - AIDS Patients
KW - Osteonecrosis -- Etiology
KW - Megestrol -- Adverse Effects
KW - Femur -- Pathology
KW - Adrenal Cortex Hormones -- Adverse Effects
KW - Magnetic Resonance Imaging
KW - Osteonecrosis -- Diagnosis
KW - Hip -- Radiography
KW - Adult
KW - Middle Age
KW - Male
SP - 405
EP - 410
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 14
IS - 8
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Parklawn Bldg, Room 14B04, HFD 510, 5600 Fishers Lane, Rockville, MD 20857; Kollere@cder.fda.gov
U2 - PMID: 10977969.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107048769
T1 - FDA perspective. Protecting consumers by safeguarding animal health.
AU - Sundlof SF
Y1 - 2000/08//8/1/2000
N1 - Accession Number: 107048769. Language: English. Entry Date: 20010831. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Food Supply -- Standards
KW - United States Food and Drug Administration -- Standards
KW - Veterinary Medicine
KW - United States
KW - Animals
SP - 659
EP - 660
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 62
IS - 3
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Food and Drug Administration, Rockville, MD
U2 - PMID: 10950218.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - WHALEY, DAVID A.
AU - ATTFIELD, MICHAEL D.
AU - BEDILLION, ERIK J.
AU - WALTER, KENNETH M.
AU - QUILONG YI
T1 - Regression method to estimate provisional TLV/WEEL-equivalents for non-carcinogens.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2000/08//
VL - 44
IS - 5
M3 - Article
SP - 361
EP - 374
SN - 00034878
AB - There is a huge and changing number of chemicals in commerce for which workplace exposure criteria have not been assigned. Assigning an exposure criterion by an expert committee is resource-intensive—not soon available for the large majority of chemicals in current use. In the absence of assigned criteria, we have provided a regression method to estimate a first-screen estimate of a ‘TLV/WEEL-equivalent’ inhalation time-weighted average exposure criterion for a pure chemical (or chemical group) from a measure of a non-stochastic toxic exposure to elicit a chronic or sub-chronic health effect, known as a lowest observable adverse effect level (LOAEL) or a (highest) no observable adverse effect level (NOAEL). Results are presented for six data sets for which both a threshold limit value (TLV) or workplace environmental exposure level (WEEL) exposure criterion is presently assigned, and a LOAEL or NOAEL measure of toxic health effect was available from the United States Environmental Protection Agency Integrated Risk Information System data base. The results can be applied as a first estimate of exposure to substances for which no TLV or WEEL (TLV/WEEL) exists, and also serve as a mechanism for identifying substances for potential re-evaluation of their exposure limit, based on their relative position about the prediction models. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemicals -- Safety measures
KW - Industrial safety
KW - Hazardous substances -- Risk assessment
KW - Health risk assessment
KW - United States
KW - exposure criterion
KW - exposure limits
KW - regression
KW - TLV
KW - toxicity estimates
KW - WEEL
KW - United States. Environmental Protection Agency
N1 - Accession Number: 44400075; WHALEY, DAVID A. 1; Email Address: dwhaley2@wvu.edu; ATTFIELD, MICHAEL D. 2; BEDILLION, ERIK J. 3; WALTER, KENNETH M. 4; QUILONG YI 5; Affiliations: 1: Department of Industrial Management Systems Engineering, West Virginia University, P.O. Box 6070, Morgantown, WV 26506, USA; 2: National Institute of Occupational Safety and Health (NIOSH), CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA; 3: GE Power Systems, 2690 Balltown Road, Bldg. 600, Schenectady, NY 12309, USA; 4: OO-ALC/EMC, 7274 Wardleigh Road., Hill AFB, UT 84056-5137, USA; 5: University of Toronto, Biostatistics Division, Department of Public Health Sciences, Faculty of Medicine, 12 Queens Park Crescent, Toronto, Ontario, Canada M5S 1A8; Issue Info: Aug2000, Vol. 44 Issue 5, p361; Thesaurus Term: Chemicals -- Safety measures; Thesaurus Term: Industrial safety; Thesaurus Term: Hazardous substances -- Risk assessment; Thesaurus Term: Health risk assessment; Subject: United States; Author-Supplied Keyword: exposure criterion; Author-Supplied Keyword: exposure limits; Author-Supplied Keyword: regression; Author-Supplied Keyword: TLV; Author-Supplied Keyword: toxicity estimates; Author-Supplied Keyword: WEEL ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 14p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moyer, Ernest S.
AU - Bergman, M. S.
T1 - Electrostatic N-95 Respirator Filter Media Efficiency Degradation Resulting from Intermittent Sodium Chloride Aerosol Exposure.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/08//
VL - 15
IS - 8
M3 - Article
SP - 600
EP - 608
PB - Taylor & Francis Ltd
SN - 1047322X
AB - The effects of intermittently loading small masses of sodium chloride aerosol on the filtration efficiency of N-95 filtering facepiece respirators was investigated. The National Institute for Occupational Safety and Health (NIOSH) certifies that N-95 respirators must provide at least 95 percent filtration efficiency against a sodium chloride aerosol challenge as per the respirator certification (42 CFR 84) test criteria. N-95 respirators are specified for protection against solid and water-based particulates (i.e., non-oil aerosols). New N-95 respirators from three different manufacturers were loaded with 5±1 mg of sodium chloride aerosol one day a week, over a period of weeks. Aerosol loading and penetration measurements were performed using the TSI 8130 Filter Tester. Respirators were stored uncovered on an office desktop outside the laboratory. To investigate environmental and temporal effects of filters being stored without sodium chloride exposure, control respirators were stored on the desk for various lengths of time before being initiated into weekly testing. For all manufacturers' respirators, the controls showed similar initial penetrations on their day of initiation (day zero) to those of the study samples on day zero. As the controls were tested weekly, they showed similar degradation rates to those of the study samples. Results show that some of the manufacturers' models had penetrations of greater than 5 percent when intermittently exposed to sodium chloride aerosol. It is concluded that intermittent, low-level sodium chloride aerosol loading of N-95 respirators has a degrading effect on filter efficiency. This reduction in filter efficiency was not accompanied by a significant increase in breathing resistance that would signal the user that the filter needs to be replaced. Furthermore, it was noted that the effect of room storage time prior to initial exposure was much less significant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Breathing apparatus
KW - Filter efficiency
KW - FILTER EFFICIENCY DEGRADATION
KW - Filters
KW - Respirators
KW - Sodium chloride aerosol
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 4052778; Moyer, Ernest S. 1; Bergman, M. S. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia; Issue Info: Aug2000, Vol. 15 Issue 8, p600; Thesaurus Term: Aerosols (Sprays); Subject Term: Breathing apparatus; Author-Supplied Keyword: Filter efficiency; Author-Supplied Keyword: FILTER EFFICIENCY DEGRADATION; Author-Supplied Keyword: Filters; Author-Supplied Keyword: Respirators; Author-Supplied Keyword: Sodium chloride aerosol ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 9p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1080/10473220050075608
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martin Jr, Stephen B.
AU - Moyer, Ernest S.
T1 - Electrostatic Respirator Filter Media: Filter Efficiency and Most Penetrating Particle Size Effects.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/08//
VL - 15
IS - 8
M3 - Article
SP - 609
EP - 617
PB - Taylor & Francis Ltd
SN - 1047322X
AB - New electrostatic filter media has been developed for use in 42 CFR 84 negative pressure particulate respirator filters. This respirator filter media was not available for evaluation prior to the change from 30 CFR 11 to 42 CFR 84. Thus, characterization of this filter media is warranted. In this study, the new 42 CFR 84 electrostatic respirator filters were investigated with respect to filter penetration and most penetrating particle size. Three different models of N95 filters, along with one model each of the N99, R95, and P100 class filters were used in this study. First, three of each filter were loaded with a sodium chloride (NaCl) aerosol, and three of each filter were loaded with a dioctyl phthalate (DOP) aerosol to obtain normal background penetration results for each filter. Then, two new filters of each type were dipped in isopropanol for 15 seconds and allowed to dry. This isopropanol dip should reduce or eliminate any electrostatic charge on the fibers of each filter, as reported in the technical literature. These dipped filters, along with controls of each filter type, were tested on a TSI 8160 filter tester to determine the most penetrating particle size. These same filters were then tested against a NaCl aerosol to get final penetration values. Electret filters rely heavily on their electrostatic charge to provide adequate filter efficiencies, and correlations between penetration and a filter’s electrostatic characteristics are found in the technical literature. In all six of the filter models tested, filter penetration values increased considerably and the most penetrating particle size noticeably shifted toward larger particles. These results are important in better understanding how these new filter materials perform under various conditions, and they indicate the need for additional research to define environmental conditions that may affect electrostatic filter efficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Filters & filtration
KW - Breathing apparatus
KW - Electrostatic
KW - Filter efficiency
KW - Filters
KW - MOST PENETRATING PARTICLE SIZE
KW - Respirators
N1 - Accession Number: 4052777; Martin Jr, Stephen B. 1; Moyer, Ernest S. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Aug2000, Vol. 15 Issue 8, p609; Thesaurus Term: Filters & filtration; Subject Term: Breathing apparatus; Author-Supplied Keyword: Electrostatic; Author-Supplied Keyword: Filter efficiency; Author-Supplied Keyword: Filters; Author-Supplied Keyword: MOST PENETRATING PARTICLE SIZE; Author-Supplied Keyword: Respirators; Number of Pages: 9p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/10473220050075617
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hrinczenko, Borys W.
AU - Alayash, Abdu I.
AU - Wink, David A.
AU - Gladwin, Mark T.
AU - Rodgers, Griffin P.
AU - Schechter, Alan N.
T1 - Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2000/08//
VL - 110
IS - 2
M3 - Article
SP - 412
EP - 419
SN - 00071048
AB - A mechanism has been proposed in which nitric oxide (NO) may bind to cysteine β93 and be transported by haemoglobin from the lungs to the tissues and modify vascular tone. In addition, it has been reported that treatment of sickle cell anaemia blood with 80 p.p.m. NO gas in air shifts the oxygen affinity, as measured by P50 to the left. We exposed normal and sickle cell anaemia blood to 80 p.p.m. NO in air for 1 h in vitro and found no change in P50 of either normal or sickle cell blood. In addition, we exposed normal and sickle cell blood in buffer to aqueous NO (NO gas dissolved in buffer) at varying concentrations and found that the induced left shift in P50 correlates strongly and linearly with methaemoglobin formation. We also treated normal and sickle cell blood with other nitric oxide donors, such as sodium 2-(N,N-diethylamino)-diazenolate-2-oxide (DEANO), S-nitrosocysteine (CysNO) and sodium trioxodinitrate (OXINO, or Angeli's salt). In all cases, we found a dose-dependent increase in methaemoglobin that was strongly correlated with the dose-dependent P50 reduction. Our data do not support the report that low NO concentrations can selectively increase the oxygen affinity of sickle cell blood without affecting methaemoglobin levels significantly. NO, however, may have benefit in sickle cell disease by other mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITRIC oxide
KW - ERYTHROCYTES
KW - OXYGEN -- Physiological transport
KW - SICKLE cell anemia
KW - PHYSIOLOGY
KW - haemoglobin
KW - methaemoglobin
KW - nitric oxide
KW - oxygen affinity
KW - sickle cell anaemia
N1 - Accession Number: 5604678; Hrinczenko, Borys W. 1; Alayash, Abdu I. 2; Wink, David A. 3; Gladwin, Mark T. 4; Rodgers, Griffin P. 5; Schechter, Alan N. 1; Source Information: Aug2000, Vol. 110 Issue 2, p412; Subject: NITRIC oxide; Subject: ERYTHROCYTES; Subject: OXYGEN -- Physiological transport; Subject: SICKLE cell anemia; Subject: PHYSIOLOGY; Author-Supplied Keyword: haemoglobin; Author-Supplied Keyword: methaemoglobin; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: oxygen affinity; Author-Supplied Keyword: sickle cell anaemia; Number of Pages: 8p; Illustrations: 4 Graphs; Document Type: Article; Full Text Word Count: 5906
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Larsen, Ulla
AU - Yan, Sharon
T1 - DOES FEMALE CIRCUMCISION AFFECT INFERTILITY AND FERTILITY? A STUDY OF THE CENTRAL AFRICAN REPUBLIC, COTE D'IVOIRE, AND TANZANIA.
JO - Demography
JF - Demography
Y1 - 2000/08//
VL - 37
IS - 3
M3 - Article
SP - 313
EP - 321
SN - 00703370
AB - The article examines the effect of female circumcision on fertility and infertility in women in Africa. The main finding of this analysis is that female circumcision is not associated with increased infertility nor with reduced fertility in the Central African Republic, Côte d'Ivoire, and Tanzania. Specifically, the relative odds of infertility and the relative odds of having a child do not differ between uncircumcised and circumcised women, regardless of their age at circumcision, when the confounding effects of socioeconomic, demographic and cultural characteristics are taken into account. Comparing the fertility of circumcised and uncircumcised women yields suggestive, but far from conclusive, information about the health effects of circumcision. One does not know what the fertility of circumcised women would have been, had they not been circumcised. Suppose that women who strongly prefer large families are those who are circumcised. They may have more children than uncircumcised women, but still may have fewer than if they had not been circumcised.
KW - FEMALE genital mutilation
KW - HUMAN fertility
KW - INFIBULATION
KW - CHILDLESSNESS
KW - CENTRAL African Republic
KW - TANZANIA
KW - COTE d'Ivoire
N1 - Accession Number: 3589669; Larsen, Ulla 1; Email Address: Ullarsen@hasph.harvard.edu; Yan, Sharon 2; Affiliations: 1: Department of Population and International Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115; 2: Center for Drug Evaluation and Research, Food and Drug Administration.; Issue Info: Aug2000, Vol. 37 Issue 3, p313; Subject Term: FEMALE genital mutilation; Subject Term: HUMAN fertility; Subject Term: INFIBULATION; Subject Term: CHILDLESSNESS; Subject: CENTRAL African Republic; Subject: TANZANIA; Subject: COTE d'Ivoire; Number of Pages: 9p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107145936
T1 - A National Institute for Occupational Safety and Health ALERT sent to hospitals and the intentions of hospital decision makers to advocate for latex allergy control measures.
AU - Maxfield A
AU - Lewis J
AU - Lachenmayr S
AU - Tisdale J
AU - Lum M
Y1 - 2000/08//
N1 - Accession Number: 107145936. Language: English. Entry Date: 20001101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Europe; Health Promotion/Education; Peer Reviewed; UK & Ireland. NLM UID: 8608459.
KW - Occupational Safety
KW - Latex Hypersensitivity -- Prevention and Control
KW - Nursing Administration
KW - Hospital Policies
KW - Occupational Exposure -- Prevention and Control
KW - Organizational Change
KW - Government Publications
KW - Random Sample
KW - Control Group
KW - Attitude to Change
KW - Interviews
KW - Logistic Regression
KW - Summated Rating Scaling
KW - Chi Square Test
KW - Factorial Design
KW - Change Theory
KW - National Institute for Occupational Safety and Health
KW - Human
SP - 463
EP - 467
JO - Health Education Research
JF - Health Education Research
JA - HEALTH EDUC RES
VL - 15
IS - 4
PB - Oxford University Press / USA
AB - This study evaluated a National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Alert concerning the risk and prevention of latex allergy among health care workers. It has been estimated that 8-12% of health care workers are sensitized to latex. NIOSH Alerts are publications that are intended to educate stakeholders about risks in the workplace; this Alert contained four recommendations for administrative control measures that hospital decision makers could adopt to reduce the risk of latex allergy to employees. The Alert was mailed to a random selection of Directors of Infection Control and Directors of Nursing in hospitals in the US. A random sample of these targeted recipients and a control group were surveyed by telephone (N = 298). Although nearly all of the respondents were concerned about latex allergy (96%), those reporting having seen the Alert were significantly more likely to report an intention to advocate for one or more of the control measures.
SN - 0268-1153
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, HHH Bldg, 200 Independence Ave SW, Washington, DC 20201
U2 - PMID: 11066463.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hayes, Benjamin B.
AU - Afshari, Aliakbar
AU - Millecchia, Lyndell
AU - Willard, Patsy A.
AU - Povoski, Stephen P.
AU - Meade, B. Jean
T1 - Evaluation of Percutaneous Penetration of Natural Rubber Latex Proteins.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/08//
VL - 56
IS - 2
M3 - Article
SP - 262
EP - 270
PB - Oxford University Press / USA
SN - 10966080
AB - Latex allergy is recognized worldwide as a serious health risk. To date, exposure assessment and intervention strategies have focused primarily on respiratory protection; this work evaluates the potential role of dermal protein penetration in the development of latex allergy. In vitro penetration models using flow-through diffusion cells and both human surgical specimens and hairless guinea pig skin (CrL: IAF/HA) demonstrated iodinated latex proteins (ammoniated and non-ammoniated) penetrating into and through both intact and abraded skin. Although less than 1% penetration was observed with intact skin, up to 23% of latex proteins applied to abraded skin were recovered from receptor fluid within 24 h of exposure. Phosphoimaging of the concentrated effluent revealed proteins ranging in size from 3 to 26 kDa. Using a 3H2O penetration assay to evaluate barrier integrity, the amount of latex protein penetration was found to positively correlate with the degree of dermabrasion. Immunohistochemistry of the skin localized latex proteins in the Langerhans cell-rich epidermis and in the dermis. Both in vitro penetration studies and immunohistochemistry supported the use of hairless guinea pig skin as a surrogate for human skin in evaluating latex protein penetration. In studies performed in vivo, 35% of hairless guinea pigs topically exposed to latex proteins (100 μg) 5 days per week for 3 months demonstrated elevations in latex-specific IgG1. The implication for these data is that the skin is not only a plausible route for latex sensitization but can be a major exposure route when the integument has been compromised. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Latex allergy
KW - Proteins
KW - Immunoglobulin G
KW - Immunohistochemistry
KW - Guinea pigs as laboratory animals
KW - dermal latex sensitization
KW - dermal protein penetration
KW - flow through diffusion cells
KW - hairless guinea pig dermal penetration model
KW - immunohistochemistry
KW - latex allergy
KW - latex specific IgG1
N1 - Accession Number: 44406003; Hayes, Benjamin B. 1; Afshari, Aliakbar 1; Millecchia, Lyndell 1; Willard, Patsy A. 1; Povoski, Stephen P. 2; Meade, B. Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, MS 4020, 1095 Willowdale Road, Morgantown, West Virginia 26505; 2: Department of Surgery, West Virginia University, Morgantown, West Virginia; Issue Info: Aug2000, Vol. 56 Issue 2, p262; Subject Term: Latex allergy; Subject Term: Proteins; Subject Term: Immunoglobulin G; Subject Term: Immunohistochemistry; Subject Term: Guinea pigs as laboratory animals; Author-Supplied Keyword: dermal latex sensitization; Author-Supplied Keyword: dermal protein penetration; Author-Supplied Keyword: flow through diffusion cells; Author-Supplied Keyword: hairless guinea pig dermal penetration model; Author-Supplied Keyword: immunohistochemistry; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: latex specific IgG1; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 2 Color Photographs, 1 Black and White Photograph, 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Papaconstantinou, Andriana D.
AU - Umbreit, Thomas H.
AU - Fisher, Benjamin R.
AU - Goering, Peter L.
AU - Lappas, Nicholas T.
AU - Brown, Ken M.
T1 - Bisphenol A-Induced Increase in Uterine Weight and Alterations in Uterine Morphology in Ovariectomized B6C3F1 Mice: Role of the Estrogen Receptor.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/08//
VL - 56
IS - 2
M3 - Article
SP - 332
EP - 339
PB - Oxford University Press / USA
SN - 10966080
AB - The ability of the environmental xenoestrogen bisphenol A (BPA) to increase uterine wet weight in the rodent remains controversial, and few studies have previously examined the effects of BPA on uterine morphology. Furthermore, it is not known whether BPA-induced uterotrophic effects are, similarly to β-estradiol (E2), mediated through the estrogen receptor (ER). In this study, we compared the effects of BPA on uterine wet weight and morphology to those of E2 in the B6C3F1 ovariectomized mouse. To examine whether these effects were mediated through the ER, the antiestrogen ICI 182,780 (ICI) was co-administered with BPA or E2. We report that subcutaneous administration of BPA at doses between 0.8 and 8 mg/day over 4 days significantly increased mean uterine wet weights above those of vehicle (corn oil)-treated mice. The uterine weight data suggest that BPA acts as a partial agonist with an EC50 of 0.72 mg/day compared to 19.4 ng/day for E2. BPA (2 mg/day) and E2 (40 ng/day) induced a significant increase in luminal epithelial height and in the thickness of both the stromal and myometrial layers of the uterus. The effects of 40 ng E2/day on all endpoints studied were reversed by 20 μg ICI/day. ICI at 200, but not 20 μg/day, was able to reverse the BPA (2 mg/day)-induced increase in both uterine wet weight and luminal epithelial height. ICI alone at 200 μg/day stimulated an increase in thickness of both the stroma and myometrium and did not reverse the effects of BPA (2 mg/day) on these layers. These results suggest that the BPA-induced increase in uterine wet weight and in luminal epithelial height in the ovariectomized B6C3F1 mouse are mediated by the ER. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Xenoestrogens
KW - Bisphenol A
KW - Cervix uteri
KW - Estradiol
KW - Myometrium
KW - Mice as laboratory animals
KW - β-estradiol (E2)
KW - β-estradiol E2)
KW - 780 (ICI)
KW - B6C3F1 mouse
KW - bisphenol A (BPA)
KW - estrogen receptor (ER)
KW - ICI 182
KW - ICI 182;780 (ICI)
KW - luminal epithelium
KW - myometrium
KW - stroma
KW - uterine weight
KW - uterotrophic effects
N1 - Accession Number: 44405995; Papaconstantinou, Andriana D. 1; Umbreit, Thomas H. 2; Fisher, Benjamin R. 2; Goering, Peter L.; Lappas, Nicholas T. 3; Brown, Ken M. 1; Email Address: kmb@gwu.edu; Affiliations: 1: Department of Biological Sciences, George Washington University, Washington, DC 20052; 2: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, 20857; 3: Department of Forensic Sciences, George Washington University, Washington, DC 20052; Issue Info: Aug2000, Vol. 56 Issue 2, p332; Thesaurus Term: Xenoestrogens; Subject Term: Bisphenol A; Subject Term: Cervix uteri; Subject Term: Estradiol; Subject Term: Myometrium; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: β-estradiol (E2); Author-Supplied Keyword: β-estradiol E2); Author-Supplied Keyword: 780 (ICI); Author-Supplied Keyword: B6C3F1 mouse; Author-Supplied Keyword: bisphenol A (BPA); Author-Supplied Keyword: estrogen receptor (ER); Author-Supplied Keyword: ICI 182; Author-Supplied Keyword: ICI 182;780 (ICI); Author-Supplied Keyword: luminal epithelium; Author-Supplied Keyword: myometrium; Author-Supplied Keyword: stroma; Author-Supplied Keyword: uterine weight; Author-Supplied Keyword: uterotrophic effects; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-04284-007
AN - 2002-04284-007
AU - Ponce, Rafael A.
AU - Bartell, Scott M.
AU - Wong, Eva Y.
AU - LaFlamme, Denise
AU - Carrington, Clark
AU - Lee, Robert C.
AU - Patrick, Donald L.
AU - Faustman, Elaine M.
AU - Bolger, Michael
T1 - Use of Quality-Adjusted Life Year Weights with Dose-Response Models for Public Health Decisions: A Case Study of the Risks and Benefits of Fish Consumption.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2000/08//
VL - 20
IS - 4
SP - 529
EP - 542
CY - United Kingdom
PB - Blackwell Publishing
SN - 0272-4332
SN - 1539-6924
AD - Ponce, Rafael A., University of Washington, Department of Environmental Health, 4225 Roosevelt Way NE #300, Seattle, WA, US, 98105-6099
N1 - Accession Number: 2002-04284-007. PMID: 11051076 Partial author list: First Author & Affiliation: Ponce, Rafael A.; Department of Environmental Health, University of Washington, Seattle, WA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Public Health; Risk Management; Risk Assessment. Minor Descriptor: Fishes; Food; Myocardial Infarctions. Classification: Research Methods & Experimental Design (2260); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Aug, 2000.
AB - Risks associated with toxicants in food are often controlled by exposure reduction. A quantitative method for risk-benefit analysis is presented that allows for consideration of diverse health endpoints that differ in their impact using dose-response modeling weighted by quality-adjusted life years saved. To demonstrate the usefulness of this method, the risks and benefits of fish consumption are evaluated using a single health risk and health benefit endpoint. Benefits are defined as the decrease in myocardial infarction mortality resulting from fish consumption, and risks are defined as the increase in neurodevelopmental delay resulting from prenatal methylmercury exposure. Fish consumption rates are based on information from Washington State. It is demonstrated that across a range of fish methylmercury concentrations (0-1 ppm) and intake levels, individuals would have to weight the neurodevelopmental effects 6 times more or 250 times less than the myocardial infarction benefits in order to be ambivalent about whether or not to consume fish. These methods can be generalized to evaluate the merits of other public health and risk management programs that involve trade-offs between risks and benefits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality adjusted life year weights
KW - dose response models
KW - public health
KW - fish consumption
KW - risk analysis
KW - myocardial infarctions
KW - 2000
KW - Public Health
KW - Risk Management
KW - Risk Assessment
KW - Fishes
KW - Food
KW - Myocardial Infarctions
KW - 2000
DO - 10.1111/0272-4332.204050
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UR - ORCID: 0000-0002-3085-6403
UR - ORCID: 0000-0001-7797-2906
UR -
UR - rponce@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Jaycox, Larry B.
AU - Olsen, Larry D.
T1 - Determination of Total Sulfur Compounds and Benzothiazole in Asphalt Fume Samples by Gas Chromatography with Sulfur Chemiluminescence Detection.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/09//
VL - 15
IS - 9
M3 - Article
SP - 695
EP - 704
PB - Taylor & Francis Ltd
SN - 1047322X
AB - As part of a collaborative project between the National Institute for Occupational Safety and Health and the Federal Highway Administration to evaluate asphalt pavers' exposures to asphalt fume and their potential health effects, a method was developed for the determination of total sulfur compounds and benzothiazole in asphalt fume samples. Asphalt fume samples were collected from asphalt mixtures with and without the addition of ground-up rubber tires. The asphalt fume samples were collected with sampling trains that consisted of a Teflon membrane filter and an XAD-2 adsorbent tube. Filter and sampling tube media were extracted with hexane and subsequently analyzed by gas chromatography with a sulfur chemiluminescence detector. Separation was achieved with a 100 percent dimethyl polysiloxane fused silica column. Typical calibration curves had linear correlation coefficients of 0.99 or better with a relative standard deviation (RSD) of 5 percent. Benzothiazole desorption efficiency (DE) determined using spiked sampling tubes ranged from 96.5 percent at 5.0 μg to 89.4 percent at 40 μg with RSD values from 0.9 to 4.0 percent. Benzothiazole storage recovery determined using sampling tubes spiked at 20 μg and refrigerated for 30 days at 4°C was 89.8 percent when corrected for the DE with an RSD of 1.1 percent. The limit of detection for the method determined using spiked sampling tubes was 0.30 μg. Quantitation for total sulfur compounds and benzothiazole was against benzothiazole standards in hexane. Because of detector selectivity, sample preparation consisted of a simple hexane extraction even when samples had a high background due to hydrocarbon overload. Detector sensitivity provided quantitation in the sub-microgram region. Because of the sample preparation step and because benzothiazole was determined during the same analysis run, this method is straightforward and analytically efficient. The method has been used to analyze asphalt fume samples collected at several asphalt paving and roof operations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sulfur compounds
KW - Asphalt pavements
KW - Benzothiazine
KW - ANALYTICAL METHODS DEVELOPMENT
KW - Asphalt fume
KW - benzothiazole
KW - Chemiluminescence
KW - Construction
KW - GAS CHROMATOGRAPHY
KW - ORGANIC SULFUR-CONTAINING COMPOUNDS
N1 - Accession Number: 3969715; Jaycox, Larry B. 1; Olsen, Larry D. 1; Affiliations: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Sep2000, Vol. 15 Issue 9, p695; Thesaurus Term: Sulfur compounds; Thesaurus Term: Asphalt pavements; Subject Term: Benzothiazine; Author-Supplied Keyword: ANALYTICAL METHODS DEVELOPMENT; Author-Supplied Keyword: Asphalt fume; Author-Supplied Keyword: benzothiazole; Author-Supplied Keyword: Chemiluminescence; Author-Supplied Keyword: Construction; Author-Supplied Keyword: GAS CHROMATOGRAPHY; Author-Supplied Keyword: ORGANIC SULFUR-CONTAINING COMPOUNDS; NAICS/Industry Codes: 324121 Asphalt Paving Mixture and Block Manufacturing; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10473220050110112
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Patterns and Costs for Hypertension Treatment in the United States: Clinical, Lifestyle and Socioeconomic Predictors from the 1987 National Medical Expenditures Survey.
AU - Huttin, C.
AU - Moeller, J.F.
AU - Stafford, R.S.
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
Y1 - 2000/09//
VL - 20
IS - 3
SP - 181
EP - 195
SN - 11732563
N1 - Accession Number: 9523113; Author: Huttin, C.: 1 Author: Moeller, J.F.: 2 Author: Stafford, R.S.: 3 ; Author Affiliation: 1 Faculty of Economics, Business Department, University of Paris X, Paris, France: 2 Agency for Healthcare Research and Quality, Center for Cost and Financing Studies, Rockville, Maryland, USA: 3 Partners/Massachusetts General Hospital, Institute for Health Policy, Boston, Massachusetts, USA; No. of Pages: 15; Language: English; Publication Type: Article; Update Code: 20030416
N2 - Objective: To estimate the impact of clinical and non-clinical predictors of patterns of medication use and expenditures for the treatment of hypertension in the USA. Data Sources: The 1987 National Medical Expenditures Survey was used to identify 6398 individuals with hypertension over the age of 18 years. Pharmacological treatment was identified through patient self-reports of antihypertensive medications. Study Design: This retrospective, cross-sectional study used a multivariate two-stage decision model to estimate the demand for antihypertensive medications conditional on receipt of at least one antihypertensive prescription drug. Results: Women and the elderly were more likely to obtain medications and had greater expenditures on antihypertensive medications. Privately insured patients were 59% (if non-elderly) or 163% (if elderly with Medicare) more likely to receive drug therapy than uninsured patients. Patients with only Medicaid coverage were 126% more likely to receive drug therapy than uninsured patients. Compared with patients characterised as lower risk-takers, very high and high risk-takers were 38% and 24% less likely to be on drug therapy, respectively. Black, non-Hispanics were 30% more likely to be on drug therapy than White, non-Hispanics, but had lower annual expenditures on antihypertensive drugs. Severely overweight individuals [bodymass index (BMI) >30] were 62% more likely than patients with a BMI <27 to be on drug therapy and also had higher drug expenditures. Conclusions: Insurance had a more striking effect on access to antihypertensive drug therapy than on patterns of drug use or expenditures. Race/ethnicity and patient attitudes towards risk were important determinants of access to antihypertensive drug therapies, as well as patterns of drug use and expenditures. ABSTRACT FROM AUTHOR
KW - *HYPERTENSION
KW - *ANTIHYPERTENSIVE agents
KW - *MEDICAL care costs
KW - TREATMENT
KW - UNITED States
KW - Antihypertensives, therapeutic use
KW - Cost analysis
KW - Health services accessibility
KW - Hypertension, treatment
KW - Pharmacoeconomics
KW - Reimbursement
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - RITH-NAJARIAN, STEPHEN
AU - GOHDES, DOROTHY
AU - MCGRATH, NICOLE M.
AU - CURRAN, BRONWYN A.
T1 - Preventing Amputations Among Patients With Diabetes on Dialysis.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2000/09//
VL - 23
IS - 9
M3 - Article
SP - 1445
EP - 1446
SN - 01495992
N1 - Accession Number: 96717261; RITH-NAJARIAN, STEPHEN 1; Email Address: srithnajarian@nchs.com; GOHDES, DOROTHY; MCGRATH, NICOLE M. 2; Email Address: nicole@nhl.co.nz; CURRAN, BRONWYN A. 2; Source Information: Sep2000, Vol. 23 Issue 9, p1445; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107148291
T1 - Use of accelerometers as an ergonomic assessment method for arm acceleration -- a large-scale field trial.
AU - Estill CF
AU - MacDonald LA
AU - Wenzl TB
AU - Petersen MR
Y1 - 2000/09//
N1 - Accession Number: 107148291. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; forms; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Visual Analog Scaling. NLM UID: 0373220.
KW - Accelerometry
KW - Instrument Validation
KW - Arm
KW - Stress, Physiological -- Evaluation
KW - Biomechanics
KW - Occupational-Related Injuries
KW - Musculoskeletal System -- Pathology
KW - Ergonomics
KW - Mathematics
KW - Convenience Sample
KW - T-Tests
KW - One-Way Analysis of Variance
KW - Visual Analog Scaling
KW - Scales
KW - Descriptive Statistics
KW - Data Analysis Software
KW - Job Characteristics
KW - United States
KW - Human
SP - 1430
EP - 1445
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 43
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway -- R5, Cincinnati, Ohio 45226; clf4@cdc.gov
U2 - PMID: 11014762.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107148291&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Denovan, L. A.
AU - Lu, C.
AU - Hines, C. J.
AU - Fenske, R. A.
T1 - Saliva biomonitoring of atrazine exposure among herbicide applicators.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2000/09//
VL - 73
IS - 7
M3 - Article
SP - 457
EP - 462
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - A field study was conducted in which saliva samples were collected from a cohort of herbicide applicators during the pre-emergent spray season in Ohio in 1996. Atrazine concentrations were detected in human saliva samples using an enzyme-linked immunosorbent assay (ELISA) method. Trend due to atrazine exposure and subsequent elimination in the body were evidenced by the temporal pattern of decreasing atrazine concentrations in saliva over time. Median salivary concentrations of atrazine on non-spray days were significantly lower than on spray days for each sampling time (Mann-Whitney U–Wilcoxon rank sum test, P < 0.01). Within spray days, median salivary atrazine concentrations were significantly higher on days atrazine was sprayed than on days herbicides other than atrazine were sprayed for each sampling time (Mann-Whitney U–Wilcoxon rank sum test, P=0.02 for 4–6 p.m. samples, P=0.04 for bedtime samples, P=0.03 for next-morning samples). Median salivary atrazine concentrations on days atrazine was sprayed were higher than the median concentration for the corresponding sampling time on non-spray days and on days when other herbicides were sprayed. Salivary concentration of atrazine is a plausible indicator of those days in which atrazine spraying was likely to have occurred. Salivary concentrations of atrazine not only reflect exposures resulting from spraying atrazine, but also exposures from other field activities where applicators may come in contact with atrazine. The results of this study confirmed data from animal experiments that atrazine is able to cross the cell membranes of salivary glands, and can be measured in human saliva with high sensitivity. The sampling method itself is convenient and easy to use in the field, with a high compliance rate, and analytical procedures are rapid and inexpensive. It is, therefore, concluded that saliva sampling of atrazine exposure among herbicide applicators is a feasible biomonitoring method. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Herbicides
KW - Cell membranes
KW - Pesticides
KW - Saliva
KW - Enzyme-linked immunosorbent assay
KW - Enzymes
KW - Atrazine
KW - Biomonitoring
KW - Herbicide
KW - Pesticide exposure
N1 - Accession Number: 16129402; Denovan, L. A. 1; Lu, C. 1; Email Address: calu@u.washington.edu; Hines, C. J. 2; Fenske, R. A. 1; Affiliations: 1: Box 357234, Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195-7234, USA.; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; Issue Info: Sep2000, Vol. 73 Issue 7, p457; Thesaurus Term: Herbicides; Thesaurus Term: Cell membranes; Thesaurus Term: Pesticides; Subject Term: Saliva; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Enzymes; Author-Supplied Keyword: Atrazine; Author-Supplied Keyword: Biomonitoring; Author-Supplied Keyword: Herbicide; Author-Supplied Keyword: Pesticide exposure; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107007629
T1 - Continuing education meets the learning organization: the challenge of a systems approach to patient safety.
AU - Eisenberg JM
Y1 - 2000/09//
N1 - Accession Number: 107007629. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. NLM UID: 8805847.
KW - Education, Medical, Continuing
KW - Patient Safety
KW - Treatment Errors -- Prevention and Control
KW - Health Care Delivery
KW - Physicians
KW - Systems Theory
KW - Systems Design
KW - United States Agency for Healthcare Research and Quality
KW - Physician's Role
KW - Organizational Change
KW - Behavioral Changes
KW - Continuing Education Providers
KW - Learning Methods
KW - Program Development
KW - Quality Improvement
SP - 197
EP - 207
JO - Journal of Continuing Education in the Health Professions
JF - Journal of Continuing Education in the Health Professions
JA - J CONTIN EDUC HEALTH PROF
VL - 20
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Since the release of the report of the Institute of Medicine on medical errors and patient safety in November 1999, health policy makers and health care leaders in several nations have sought solutions that will improve the safety of health care. This attention to patient safety has highlighted the importance of a learning approach and a systems approach to quality measurement and improvement. Balanced with the need for public disclosure of performance, confidential reporting with, feedback is one of the prime ways that nations such as the United States, Canada, the United Kingdom, and Australia have approached this challenge. In the United States, the Quality Interagency Coordination Task Force has convened federal agencies that are involved in health care quality improvement for a coordinated initiative. Based on an investment in a strong research foundation in health care quality measurement and improvement, there are eight key lessons for continuing education if it is to parlay the interest in patient safety into enhanced continuing education and quality improvement in learning health care systems. The themes for these lessons are (1) informatics for information, (2) guidelines as learning tools, (3) learning from opinion leaders, (4) learning from the patient, (5) decision support systems, (6) the team learning together, (7) learning organizations, and (8) just-in-time and point-of-care delivery.
SN - 0894-1912
AD - Director, Agency for Healthcare Research and Quality, US Department of Health and Human Services, 2101 East Jefferson Ave, Rockville, MD 20852
U2 - PMID: 11201059.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mukamel, Dana B.
AU - Dick, Andrew
AU - Spector, William D.
T1 - Specification issues in measurement of quality of medical care using risk adjusted outcomes.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2000/09//
VL - 26
IS - 3/4
M3 - Article
SP - 267
EP - 280
PB - IOS Press
SN - 07479662
AB - Governments and private organizations have recently begun publishing "report cards" that compare quality of hospitals, physicians and health care plans. Often these reports include quality measures based on risk adjusted health outcomes of the patients treated by each health care provider. The use of these measures is, however, controversial due to concerns about their accuracy. To-date, concerns focused on the risk adjustment methodology and small sample sizes. We raise an additional issue related to the definition of quality measures as either the difference between observed and predicted outcome rates or the ratio between these rates. A theoretical analysis of the properties of the two measures is presented. Monte Carlo simulations quantify the effects identified in the theoretical analysis. We show that the two risk adjusted outcome measures of quality may lead to different conclusions about relative quality among providers. Which measure should be used depends on the underlying relationship between patient risks and quality of care in determining health outcomes. For the case replicating the HCFA hospital mortality statistics, the percent of true outliers identified by the incorrect measure ranges from 64% to 78%. The issue raised in this manuscript is relevant to areas other than health care, where performance is measured based on outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - STATISTICS
KW - HOSPITALS
KW - PUBLIC health
KW - HEALTH planning
KW - MORTALITY
KW - quality assessment
KW - quality measurement
KW - Quality of care
KW - quality report cards
KW - risk-adjusted outcomes
N1 - Accession Number: 5561569; Mukamel, Dana B. 1; Email Address: Dana_Mukamel@urmc.rochester.edu; Dick, Andrew 1; Spector, William D. 2; Affiliations: 1: Department of Community and Preventive Medicine, University of Rochester, Rochester, NY, USA; 2: Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD, USA; Issue Info: 2000, Vol. 26 Issue 3/4, p267; Thesaurus Term: MEDICAL care; Thesaurus Term: STATISTICS; Thesaurus Term: HOSPITALS; Subject Term: PUBLIC health; Subject Term: HEALTH planning; Subject Term: MORTALITY; Author-Supplied Keyword: quality assessment; Author-Supplied Keyword: quality measurement; Author-Supplied Keyword: Quality of care; Author-Supplied Keyword: quality report cards; Author-Supplied Keyword: risk-adjusted outcomes; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Chernew, Michael E.
AU - Encinosa, William E.
AU - Hirth, Richard A.
T1 - Optimal health insurance: the case of observable, severe illness.
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2000/09//
VL - 19
IS - 5
M3 - Article
SP - 585
EP - 609
SN - 01676296
AB - We explore optimal cost-sharing provisions for insurance contracts when individuals have observable, severe diseases with a discrete number of medically appropriate treatment options. Variation in preferences for alternative treatments is unobserved by the insurer and non-contractible. Interest in such situations is increasingly common, exemplified by disease cane-out programs and shared decision-making (SDM) tools. We demonstrate that optimal insurance charges a copay to patients choosing the high-cost treatment and provides consumers of the low-cost treatment a cash payment. A simulation of the effect of such a policy, based on prostate cancer, indicates a substantial reduction in moral hazard. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE
KW - HEALTH insurance
KW - THERAPEUTICS
KW - CONTRACTS
KW - COST
KW - INSURANCE companies
KW - PAYMENT
KW - PERSONS
KW - Health insurance
KW - Moral hazard
KW - Treatment-specific copayments
N1 - Accession Number: 11945410; Chernew, Michael E. 1; Email Address: mchernew@sph.umich.edu; Encinosa, William E. 2; Hirth, Richard A. 3; Source Information: Sep2000, Vol. 19 Issue 5, p585; Subject: INSURANCE; Subject: HEALTH insurance; Subject: THERAPEUTICS; Subject: CONTRACTS; Subject: COST; Subject: INSURANCE companies; Subject: PAYMENT; Subject: PERSONS; Author-Supplied Keyword: Health insurance; Author-Supplied Keyword: Moral hazard; Author-Supplied Keyword: Treatment-specific copayments; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107027096
T1 - Perspectives in practice. Status of nutrition labeling, health claims, and nutrient content claims for processed foods: 1997 Food Label and Package Survey.
AU - Brecher SJ
AU - Bender MM
AU - Wilkening VL
AU - McCabe NM
AU - Anderson EM
Y1 - 2000/09//
N1 - Accession Number: 107027096. Language: English. Entry Date: 20010601. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Food Labeling -- United States
KW - Survey Research
KW - United States
KW - United States Food and Drug Administration
KW - Food Labeling -- Legislation and Jurisprudence -- United States
KW - Nutrients -- Analysis
KW - Health Food
KW - Consumer Health Information
KW - Dietitians
KW - Human
SP - 1057
EP - 1062
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 100
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Nutritionist, Food and Drug Administration, Center for Food Safety and Applied Nutrition/Office of Nutritional Products, Labeling and Dietary Supplements, 200 C St, SW, Washington, DC 20204
U2 - PMID: 11019354.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107058613
T1 - FDA guidance for IV catheter market clearance.
AU - Scott W
Y1 - 2000///2000 Fall
N1 - Accession Number: 107058613. Language: English. Entry Date: 20011012. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9604388.
KW - Catheters, Vascular
KW - Product Development
KW - United States Food and Drug Administration
KW - Product Labeling
SP - 18
EP - 19
JO - Journal of Vascular Access Devices
JF - Journal of Vascular Access Devices
JA - J VASC ACCESS DEVICES
VL - 5
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1083-0081
AD - Director, Health Promotion Officer, FDA Center for Devices & Radiological Health, Office of Health & Industry Programs, Division of Device User Programs & Systems Analysis, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107135589
T1 - Device safety. Sending the wrong signals...electrical current that may interfere with the minute ventilation sensor
AU - Dwyer D
Y1 - 2000/09//
N1 - Accession Number: 107135589. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Cardiac Pacing, Artificial
KW - Equipment Safety
KW - Pacemaker, Artificial -- Adverse Effects
KW - Electricity
SP - 69
EP - 69
JO - Nursing
JF - Nursing
JA - NURSING
VL - 30
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health Food and Drug Administration, Rockville, Md
U2 - PMID: 11022549.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107148037
T1 - Nurse salaries in Washington DC and nationally.
AU - Charles JP
AU - Piper S
AU - Mailey SK
AU - Davis P
AU - Baigis J
Y1 - 2000/09//Sep/Oct2000
N1 - Accession Number: 107148037. Language: English. Entry Date: 20001201. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8404213.
KW - Salaries and Fringe Benefits -- District of Columbia
KW - Nurses
KW - Mail
KW - Survey Research
KW - Sampling Methods
KW - District of Columbia
KW - United States
KW - Descriptive Statistics
KW - Educational Status
KW - Health Facilities
KW - Salaries and Fringe Benefits -- United States
KW - Human
SP - 243
EP - 249
JO - Nursing Economic$
JF - Nursing Economic$
JA - NURS ECON
VL - 18
IS - 5
CY - Pitman, New Jersey
PB - Jannetti Publications, Inc.
AB - The District of Columbia is overstaffed compared to the rest of the nation. The authors determined that a local area direct data collection was needed to examine nurse supply and salaries in the District of Columbia. An 11-item tool was developed by the DC Consortium and mailed to 187 employers of nurses in July of 1997. This sample included hospitals, long-term care facilities, home health agencies. The initial response rate was only 34%, however telephone and direct followup raised this to 81%. The ranges of salaries for several categories of nurses including nurse assistants, LPNs, and both basic and advanced practice nurses were tracked. Expected salary advances were also estimated according to institutional responses. 'Across DC facilities higher salaries and wider salary ranges exist for those with higher skill levels and advanced preparation.' 'Demand for skilled RNs in hospitals will increase by 36% by the year 2020.'
SN - 0746-1739
AD - Project Manager, Walcoff Technologies, Agency for Healthcare Research and Quality, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Caner, C.
AU - Hernandez, R. J.
AU - Pascall, M. A.
T1 - Effect of high-pressure processing on the permeance of selected high-barrier laminated films.
JO - Packaging Technology & Science
JF - Packaging Technology & Science
Y1 - 2000/09//
VL - 13
IS - 5
M3 - Article
SP - 183
EP - 195
SN - 08943214
AB - This study investigated the effects of high pressure processing (HPP) on the barrier properties of eight multilayer films. Pouches made from these films were filled with distilled water, sealed and then pressure processed at 600 and 800 MPa for 5, 10 and 20 min at 45°C. Controls were similarly prepared but exposed to atmospheric pressure. After processing, all pouches were dried and their oxygen, carbon dioxide and water vapour permeance determined. Films used in this study were PET/SiOx /LDPE, PET/Al2O3/LDPE, PET/PVDC/nylon/HDPE/PE, PE/nylon/EVOH/PE, PE/nylon/PE, metallized-PET/EVA/LLDPE, PP/nylon/PP and PET/PVDC/EVA. Results showed that metallized PET was most severely affected by HPP, as its permeance values for oxygen, carbon dioxide and water increased as much as 150%. Copyright © 2000 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Packaging Technology & Science is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64197863; Caner, C. 1; Hernandez, R. J. 1; Pascall, M. A. 2; Affiliations: 1: School of Packaging, Michigan State University, East Lansing, MI 48824, USA; 2: National Center for Food Safety and Technology (NCFST)/Food and Drug Administration (FDA), 6502 South Archer Rd., Summit-Argo, IL 60501, USA; Issue Info: Sep2000, Vol. 13 Issue 5, p183; Number of Pages: 13p; Document Type: Article
L3 - 10.1002/1099-1522(200009)13:5<183::AID-PTS514>3.0.CO;2-U
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107023360
T1 - CDRH summary report. FDA summarizes radiation therapy device problems.
AU - Kaczmarek RV
Y1 - 2000///Fall2000
N1 - Accession Number: 107023360. Language: English. Entry Date: 20010518. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9206619.
KW - Radiotherapy -- Equipment and Supplies
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 208
EP - 208
JO - Radiation Therapist
JF - Radiation Therapist
JA - RADIAT THERAPIST
VL - 9
IS - 2
CY - Alburquerque, New Mexico
PB - American Society of Radiologic Technologists
SN - 1084-1911
AD - FDA's Center for Devices and Radiological Health
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thompson, Karol L.
AU - Rosenzweig, Barry A.
AU - Tsong, Yi
AU - Sistare, Frank D.
T1 - Evaluation of in Vitro Reporter Gene Induction Assays for Use in a Rapid Prescreen for Compound Selection to Test Specificity in the Tg.AC Mouse Short-Term Carcinogenicity Assay.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/09//
VL - 57
IS - 1
M3 - Article
SP - 43
EP - 53
PB - Oxford University Press / USA
SN - 10966080
AB - Under ICH guidelines, short-term carcinogenicity assays such as the Tg.AC assay are allowed alternatives for one species in the 2-year rodent bioassay. The Tg.AC transgenic mouse, which carries the v-Ha-ras oncogene under control of the ζ-globin promoter, develops skin papillomas in response to dermal application of carcinogens and tumor promoters. The appropriate specificity of the Tg.AC model for testing pharmaceuticals has not been systematically evaluated. The selection of candidate test compounds among noncarcinogenic pharmaceuticals would be aided by a high-throughput in vitro prescreen correlative of activity in the in vivo Tg.AC assay. Here we describe the development of a prescreen based on correct response to 24 compounds tested previously in Tg.AC mice. The in vitro prescreens, chosen to reflect molecular pathways possibly involved in Tg.AC papilloma formation, consisted of a ζ-globin promoter-luciferase construct stably expressed in K562 cells (Zeta-Luc) and three of the stress-response element–chloramphenicol acetyltransferase (CAT) fusion constructs stably expressed in HepG2 cells that are part of the CAT-Tox (L)iver assay. The stress response elements chosen were the c-fos promoter, the gadd153 promoter, and p53 response element repeats. Of the four assays, the gadd153-CAT assay showed the strongest concordance with activity in the Tg.AC assay, correctly classifying 78% of Tg.AC positive and 83% of Tg.AC negative compounds. The correlation was further improved by adding the Zeta-Luc assay as a second-stage screen. These cell-based assays will be used in a novel approach to selecting candidate compounds that challenge the specificity of the Tg.AC assay toward pharmaceuticals. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity testing
KW - Biological assay
KW - Transgenic mice
KW - Oncogenes
KW - Chloramphenicol
KW - Acetyltransferases
KW - c-fos
KW - gadd153
KW - HepG2
KW - in vitro assay
KW - K562
KW - p53
KW - stress response genes
KW - Tg.AC
KW - zeta-globin
N1 - Accession Number: 44406019; Thompson, Karol L. 1; Rosenzweig, Barry A. 1; Tsong, Yi 2; Sistare, Frank D. 1; Email Address: sistare@cder.fda.gov; Affiliations: 1: Division of Applied Pharmacology Research, OTR/OPS, Food & Drug Administration, Laurel, Maryland 20708; 2: Office of Biostatistics, ORM, Center for Drug Evaluation and Research, Food & Drug Administration, Laurel, Maryland 20708; Issue Info: Sep2000, Vol. 57 Issue 1, p43; Thesaurus Term: Carcinogenicity testing; Thesaurus Term: Biological assay; Subject Term: Transgenic mice; Subject Term: Oncogenes; Subject Term: Chloramphenicol; Subject Term: Acetyltransferases; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: gadd153; Author-Supplied Keyword: HepG2; Author-Supplied Keyword: in vitro assay; Author-Supplied Keyword: K562; Author-Supplied Keyword: p53; Author-Supplied Keyword: stress response genes; Author-Supplied Keyword: Tg.AC; Author-Supplied Keyword: zeta-globin; Number of Pages: 11p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xu, Zengjun
AU - Chang, Louis W.
AU - Slikker Jr., William
AU - Ali, Syed F.
AU - Rountree, Robert L.
AU - Scallet, Andrew C.
T1 - A Dose-Response Study of Ibogaine-Induced Neuropathology in the Rat Cerebellum.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/09//
VL - 57
IS - 1
M3 - Article
SP - 95
EP - 101
PB - Oxford University Press / USA
SN - 10966080
AB - Ibogaine (IBO) is an indole alkaloid from the West African shrub, Tabernanthe iboga. It is structurally related to harmaline, and both these compounds are rigid analogs of melatonin. IBO has both psychoactive and stimulant properties. In single-blind trials with humans, it ameliorated withdrawal symptoms and interrupted the addiction process. However, IBO also produced neurodegeneration of Purkinje cells and gliosis of Bergmann astrocytes in the cerebella of rats given even a single dose (100 mg/kg, ip). Here, we treated rats (n = 6 per group) with either a single ip injection of saline or with 25 mg/kg, 50 mg/kg, 75 mg/kg, or 100 mg/kg of IBO. As biomarkers of cerebellar neurotoxicity, we specifically labeled degenerating neurons and axons with silver, astrocytes with antisera to glial fibrillary acidic protein (GFAP), and Purkinje neurons with antisera to calbindin. All rats of the 100-mg/kg group showed the same pattern of cerebellar damage previously described: multiple bands of degenerating Purkinje neurons. All rats of the 75-mg/ kg group had neurodegeneration similar to the 100-mg/kg group, but the bands appeared to be narrower. Only 2 of 6 rats that received 50 mg/kg were affected; despite few degenerating neuronal perikarya, cerebella from these rats did contain patches of astrocytosis similar to those observed with 75 or 100 mg/kg IBO. These observations affirm the usefulness of GFAP immunohistochemistry as a sensitive biomarker of neurotoxicity. None of the sections from the 25-mg/kg rats, however stained, were distinguishable from saline controls, indicating that this dose level may be considered as a no-observable-adverse-effect level (NOAEL). [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ibogaine
KW - Indole
KW - Alkaloids
KW - Tabernanthe iboga
KW - Purkinje cells
KW - Cerebellum
KW - Neurodegeneration
KW - Bergmann astrocyte
KW - calbindin
KW - cerebellum
KW - GFAP
KW - ibogaine
KW - neurodegeneration
KW - NOAEL
KW - Purkinje neuron
N1 - Accession Number: 44406014; Xu, Zengjun 1; Chang, Louis W. 1,2; Slikker Jr., William 2,3; Ali, Syed F. 2,3; Rountree, Robert L. 3; Scallet, Andrew C. 2,3; Email Address: ascallet@nctr.fda.gov; Affiliations: 1: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; 2: Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; 3: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Sep2000, Vol. 57 Issue 1, p95; Subject Term: Ibogaine; Subject Term: Indole; Subject Term: Alkaloids; Subject Term: Tabernanthe iboga; Subject Term: Purkinje cells; Subject Term: Cerebellum; Subject Term: Neurodegeneration; Author-Supplied Keyword: Bergmann astrocyte; Author-Supplied Keyword: calbindin; Author-Supplied Keyword: cerebellum; Author-Supplied Keyword: GFAP; Author-Supplied Keyword: ibogaine; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: NOAEL; Author-Supplied Keyword: Purkinje neuron; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shvedova, A.A.
AU - Kisin, E.
AU - Kisin, J.
AU - Castranova, V.
AU - Kommineni, C.
T1 - Elevated oxidative stress in skin of B6C3F1 mice affects dermal exposure to metal working fluid.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2000/09//
VL - 16
IS - 7/8
M3 - Article
SP - 267
EP - 276
PB - Sage Publications, Ltd.
SN - 07482337
AB - Metal working fluids (MWFs) are widely used in industry for metal cutting, drilling, shaping, lubricating, and milling. Potential for dermal exposure to MWFs exists for a large number of men and women via aerosols and splashing during the machining operations. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we showed that dermal exposure of female and male B6C3F1 mice to 5% MWFs for 3 months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWF also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate the interaction between oxidative stress in the skin and topical application of MWF. Oxidative stress in skin of B6C3F1 mice of both sexes was generated by intradermal injection of the hydrogen peroxide (H[sub 2]O[sub 2])-producing enzyme, glucose oxidase with polyethylene glycol (GOD+PEG). In mice given GOD+PEG, topical treatment with MWF (200 μl, 30%, for 1, 3, or 7 days) resulted in a mixed inflammatory cell response, accumulation of peroxidative products, and reduction of GSH content in the skin. Such changes were not observed with MWF treatment alone. These data indicate that oxidative stress can enhance dermal inflammation caused by occupational exposure to MWF. Toxicology and Industrial Health (2000) 16, 267–276. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Stress (Physiology)
KW - Industrial hygiene
KW - Health
KW - Skin -- Inflammation
KW - Metalwork
KW - Oxidases
KW - glucose oxidase
KW - GSH
KW - inflammation
KW - Metal working fluid
KW - oxidative stress
KW - skin
N1 - Accession Number: 6398495; Shvedova, A.A. 1; Kisin, E. 1; Kisin, J. 1; Castranova, V. 1; Kommineni, C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia 26505; Issue Info: 2000, Vol. 16 Issue 7/8, p267; Thesaurus Term: Stress (Physiology); Thesaurus Term: Industrial hygiene; Thesaurus Term: Health; Subject Term: Skin -- Inflammation; Subject Term: Metalwork; Subject Term: Oxidases; Author-Supplied Keyword: glucose oxidase; Author-Supplied Keyword: GSH; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: Metal working fluid; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: skin; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-06295-006
AN - 2002-06295-006
AU - Zuvekas, Samuel H.
AU - Hill, Steven C.
T1 - Income and employment among homeless people: The role of mental health, health and substance abuse.
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2000/09//
VL - 3
IS - 3
SP - 153
EP - 163
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Zuvekas, Samuel H., Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, 2101 East Jefferson Street, Ste. 500, Rockville, MD, US, 20852
N1 - Accession Number: 2002-06295-006. PMID: 11967451 Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, Rockville, MD, US. Release Date: 20021106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Employment Status; Health; Homeless; Mental Health. Minor Descriptor: Government Programs; Income (Economic). Classification: Psychological & Physical Disorders (3200); Social Structure & Organization (2910). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 2000.
AB - Investigated the characteristics of homeless people impede them in the labor market and in government program participation, paying particular attention to their mental and physical health, as well as their drug and alcohol problems. Data are from a survey of the homeless population in Alameda County, California (1991-1993). The sample is 471 homeless adults randomly selected from area shelters and meal providers, who were reinterviewed approximately 6 mo later, regardless of domiciliary status. While a surprising large number of homeless work, few homeless persons are able to generate significant earnings from employment alone. Physical health problems that limit work or daily activities, in particular, are barriers to employment. Drug and alcohol abuse and dependence are positively associated with lower work level but are negatively related to higher work level. Program participation is quite low relative to eligibility. Those with physical health problems are substantially more likely than those with mental health problems to be in the more generous disability programs. Substance use disorders are also a barrier to participation in disability programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - income
KW - employment
KW - homeless adults
KW - mental health
KW - health
KW - substance abuse
KW - government programs
KW - 2000
KW - Drug Abuse
KW - Employment Status
KW - Health
KW - Homeless
KW - Mental Health
KW - Government Programs
KW - Income (Economic)
KW - 2000
DO - 10.1002/mhp.94
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-06295-006&site=ehost-live&scope=site
UR - SZuvekas@AHRQ.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Burns, Ilene T.
AU - Jimmerman, Richard Kent
T1 - Haemophilus Influenzae Type B Disease, Vaccines, and Care of Exposed Individuals.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S7
EP - S14
PB - Frontline Medical Communications
SN - 00943509
AB - Before effective vaccines became available, aporoximately 1 in every 200 children aged younger than 5 years had invasive Haemophilus infiuenzae type b (Hib) disease. Hib was the most common cause cf bacterial meningitis and other invasive Dacterial diseases in this age group. Rapid diagnosis and treatment are essential for Hib meningitis, because the mortality rate is 2% to 5%, even with antibiotic treatment-usually a third-generator cephalosporin, such as cefotaxime or ceftriaxone. Because of the use of Hib vaccines, the incidence of invasive H influenzae disease in children younger thar 5 years old declined by 97% between 1987 and 1997. Recent data indicate that the conjugate Hib vaccines given in infancy can be used interchangeably. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAEMOPHILUS influenzae
KW - BACTERIAL diseases
KW - MENINGITIS in children
KW - INFLUENZA -- Vaccination
KW - VACCINATION of infants
KW - CEFOTAXIME
KW - PEDIATRIC diagnosis
KW - PEDIATRIC therapy
KW - Haemophilus influenzae
KW - Haemophilus vaccines
KW - Haemophilus.
KW - Hoemophilus influenzae
KW - maningitis
KW - meningitis, Haemophilus
N1 - Accession Number: 3842252; Burns, Ilene T.; Jimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu; Source Information: Sep2000 Vaccines, Vol. 49 Issue 9, pS7; Subject: HAEMOPHILUS influenzae; Subject: BACTERIAL diseases; Subject: MENINGITIS in children; Subject: INFLUENZA -- Vaccination; Subject: VACCINATION of infants; Subject: CEFOTAXIME; Subject: PEDIATRIC diagnosis; Subject: PEDIATRIC therapy; Author-Supplied Keyword: Haemophilus influenzae; Author-Supplied Keyword: Haemophilus vaccines; Author-Supplied Keyword: Haemophilus.; Author-Supplied Keyword: Hoemophilus influenzae; Author-Supplied Keyword: maningitis; Author-Supplied Keyword: meningitis, Haemophilus; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Zimmerman, Richard Kent
AU - Burns, Ilene T.
T1 - Child Vaccination, Part 1: Routine Vaccines.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S22
EP - S33
PB - Frontline Medical Communications
SN - 00943509
AB - Despite the success of the national childhood vaccination program in the United States in decreasing mortality due to vaccine-preventable diseases, vaccination rates remain suboptimal. Contributing factors include the failure to appreciate the hazards of vaccine-preventable diseases, concerns about adverse reactions associated with vaccine administration, and missed opportunities to administer vaccines. The 2 major types of indications for vaccinating children are age and presence of a medical condition that increases the risk of a vaccine-preventable disease. Hepatitis B virus (HBV) infection becomes chronic in 90% of those infected as infants, and 25% of those so infected will die of related chronic liver disease as adults. Routine infant vaccination against hepatitis B has been recommended since 1991. Approximately 69% of infants who develop portussis require hospitalization. Acelluar pertussis vaccines have been licensed for use in infancy. Starting in 2000, the all-inactivated poliovirus vaccine (IPV) schedule is recommended. IPV should eliminate vaccine-associated paralytic poliomyelitis Pneumococcal conjugate vaccine was licensed in 2000 for routine use on a schedule of 2,4, 6, and 12 to 15 months. The first dose of measles-mumps-rubella vaccine is now recommended at age 12 to 15 months, simultaneous with varicella vaccine administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION of children
KW - IMMUNIZATION of children
KW - MORTALITY
KW - COMMUNICABLE diseases -- Prevention
KW - HEPATITIS B
KW - MMR vaccine
KW - VIRAL vaccines
KW - VACCINATION of infants
KW - measles vaccine
KW - pertussis vaccine
KW - pneumococcal conjugate vaccine [non-MESHI]
KW - poliovirus vaccine
KW - Vaccination
KW - varicella vaccine [non-MESH]
KW - viral hepatitis vaccines
N1 - Accession Number: 3842254; Zimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu*1; Burns, Ilene T.; Source Information: Sep2000 Vaccines, Vol. 49 Issue 9, pS22; Subject: VACCINATION of children; Subject: IMMUNIZATION of children; Subject: MORTALITY; Subject: COMMUNICABLE diseases -- Prevention; Subject: HEPATITIS B; Subject: MMR vaccine; Subject: VIRAL vaccines; Subject: VACCINATION of infants; Author-Supplied Keyword: measles vaccine; Author-Supplied Keyword: pertussis vaccine; Author-Supplied Keyword: pneumococcal conjugate vaccine [non-MESHI]; Author-Supplied Keyword: poliovirus vaccine; Author-Supplied Keyword: Vaccination; Author-Supplied Keyword: varicella vaccine [non-MESH]; Author-Supplied Keyword: viral hepatitis vaccines; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Zimmerman, Richard Kent
AU - Burns, Ilene T.
T1 - Child Vaccination, Part 2.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S34
EP - S40
PB - Frontline Medical Communications
SN - 00943509
AB - The 1996, the Advisory Committee on immunization Practices (ACIP), the American Academy of Family Physicians (AAFP), the American Academy of Pediatrics (AAP), and the American Medical Association recommended a well-child office visit at age 11 to 12 years to check vaccination Status. Vaccination status should be assessed for varicella, hepatitis B. the second dose of measles-mumps-rubella (MMR) vaccine, and tetanus-diptheria (Td) toxoid if not giver in the past 5 years. Adolescent patterns should be screened for high-risk conditions indicating the need for influenza, pneumococcal, or hepatitis A vaccines. The Accelerated immunization Schedule and Minimal Interval Table should be consulted for children who are behind schedule. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - VACCINATION of children
KW - MMR vaccine
KW - INFLUENZA -- Vaccination
KW - VIRAL vaccines
KW - AMERICAN Medical Association
KW - AMERICAN Academy of Family Physicians
KW - hepatitis B vaccines
KW - influenza vaccine
KW - measles
KW - measles, mumps, rubella vaccine [non-MESH]
KW - mumps
KW - pneumococcal polysaccharide vaccine [non- MESH]
KW - pneumococcal polysaccharide vaccine [non-MESH]
KW - rubella vaccine [non-MESH]
KW - Vaccination
KW - varicella vaccine [non-MESH]
KW - varicella vaccine [non-MESH].
N1 - Accession Number: 3842255; Zimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu; Burns, Ilene T.; Source Information: Sep2000 Vaccines, Vol. 49 Issue 9, pS34; Subject: IMMUNIZATION; Subject: VACCINATION of children; Subject: MMR vaccine; Subject: INFLUENZA -- Vaccination; Subject: VIRAL vaccines; Subject: AMERICAN Medical Association; Subject: AMERICAN Academy of Family Physicians; Author-Supplied Keyword: hepatitis B vaccines; Author-Supplied Keyword: influenza vaccine; Author-Supplied Keyword: measles; Author-Supplied Keyword: measles, mumps, rubella vaccine [non-MESH]; Author-Supplied Keyword: mumps; Author-Supplied Keyword: pneumococcal polysaccharide vaccine [non- MESH]; Author-Supplied Keyword: pneumococcal polysaccharide vaccine [non-MESH]; Author-Supplied Keyword: rubella vaccine [non-MESH]; Author-Supplied Keyword: Vaccination; Author-Supplied Keyword: varicella vaccine [non-MESH]; Author-Supplied Keyword: varicella vaccine [non-MESH].; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Miller, Margaret Ann
T1 - Historical Perspective on the Regulation of Antimicrobial Residues in Food in the United States.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 8
EP - 10
PB - Co-Action Publishing
SN - 0891060X
AB - Presents the historical perspective on the regulation of antimicrobial residues in food in the United States. Entities of veterinary drug regulation; Assessment of food safety; Evaluation of antimicrobial residues.
KW - Food handling
KW - Veterinary drug residues
KW - United States
N1 - Accession Number: 4229993; Miller, Margaret Ann 1; Affiliations: 1: From the Office of Women's Health, US Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; Issue Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p8; Thesaurus Term: Food handling; Subject Term: Veterinary drug residues; Subject: United States; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/08910600050216066
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bartholomew, Mary J.
T1 - Microbiological Safety of Drug Residues in Food — Workshop Objectives.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 13
EP - 14
PB - Co-Action Publishing
SN - 0891060X
AB - Presents workshop on microbiological safety of drug residues in food by Center for Veterinary Medicine. Goal of the workshop; Significance of microbiological endpoints; Experiences of microbiologists.
KW - MICROBIOLOGY
KW - Conferences & conventions
KW - Veterinary drug residues
KW - Food
KW - CONGRESSES
N1 - Accession Number: 4229991; Bartholomew, Mary J. 1; Affiliations: 1: From the Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p13; Thesaurus Term: MICROBIOLOGY; Subject Term: Conferences & conventions; Subject Term: Veterinary drug residues; Subject Term: Food; Subject Term: CONGRESSES; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 2p; Document Type: Article
L3 - 10.1080/08910600050216084
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4229991&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cerniglia, Carl E.
T1 - The JECFA and Alternate Approaches for Determining ADIs for Antimicrobial Residues.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 30
EP - 34
PB - Co-Action Publishing
SN - 0891060X
AB - Focuses on the FAO/WHO Joint Expert Committee on Food Additives (JECFA) and its approaches in determining acceptable daily intake (ADI) for antimicrobial residues. Tasks of JECFA; Types of antimicrobial studies for ADI establishment; Effect of the veterinary drug residue on the human intestinal microflora.
KW - MICROBIOLOGY
KW - Committees
KW - Veterinary drug residues
KW - Gastrointestinal system
KW - ADVERSE MICROBIOLOGICAL EFFECTS
KW - Drug residues
KW - Intestinal microflora
KW - JECFA
KW - VETERINARY ANTIMICROBIALS
N1 - Accession Number: 4229999; Cerniglia, Carl E. 1; Affiliations: 1: From the National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p30; Thesaurus Term: MICROBIOLOGY; Subject Term: Committees; Subject Term: Veterinary drug residues; Subject Term: Gastrointestinal system; Author-Supplied Keyword: ADVERSE MICROBIOLOGICAL EFFECTS; Author-Supplied Keyword: Drug residues; Author-Supplied Keyword: Intestinal microflora; Author-Supplied Keyword: JECFA; Author-Supplied Keyword: VETERINARY ANTIMICROBIALS; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/08910600050216138
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4229999&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fernández, A. Haydée
T1 - FDA Proposal for Establishing Microbiological Acceptable Daily Intakes for Antimicrobial Residues.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 42
EP - 44
PB - Co-Action Publishing
SN - 0891060X
AB - Focuses on the establishment of a threshold acceptable daily intake (ADI) for antimicrobial residues by the United States Food and Drug Administration. Basis of ADI threshold; Impact of the residues on the intestinal microflora; Conditions for an antimicrobial drug.
KW - Anti-infective agents
KW - Veterinary drug residues
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 4229996; Fernández, A. Haydée 1; Affiliations: 1: From the Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p42; Thesaurus Term: Anti-infective agents; Subject Term: Veterinary drug residues; Subject: United States ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1080/08910600050216165
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4229996&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106993253
T1 - Postlicensure safety surveillance for varicella vaccine.
AU - Wise RP
AU - Salive ME
AU - Braun MM
AU - Mootrey GT
AU - Seward JF
AU - Rider LG
AU - Krause PR
AU - Wise, R P
AU - Salive, M E
AU - Braun, M M
AU - Mootrey, G T
AU - Seward, J F
AU - Rider, L G
AU - Krause, P R
Y1 - 2000/09/13/
N1 - Accession Number: 106993253. Language: English. Entry Date: 20010126. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Chickenpox Vaccine -- Adverse Effects
KW - Chickenpox -- Prevention and Control
KW - Case Studies
KW - Human
SP - 1271
EP - 1279
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 284
IS - 10
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Since its licensure in 1995, the extensive use of varicella vaccine and close surveillance of the associated anecdotal reports of suspected adverse effects provide the opportunity to detect potential risks not observed before licensure because of the relatively small sample size and other limitations of clinical trials.Objectives: To detect potential hazards, including rare events, associated with varicella vaccine, and to assess case reports for clinical and epidemiological implications.Design and Setting: Postlicensure case-series study of suspected vaccine adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) from March 17, 1995, through July 25, 1998.Main Outcome Measures: Numbers of reported adverse events, proportions, and reporting rates (reports per 100,000 doses distributed).Results: VAERS received 6574 case reports of adverse events in recipients of varicella vaccine, a rate of 67.5 reports per 100,000 doses sold. Approximately 4% of reports described serious adverse events, including 14 deaths. The most frequently reported adverse events were rashes, possible vaccine failures, and injection site reactions. Misinterpretation of varicella serology after vaccination appeared to account for 17% of reports of possible vaccine failures. Among 251 patients with herpes zoster, 14 had the vaccine strain of varicella zoster virus (VZV), while 12 had the wild-type virus. None of 30 anaphylaxis cases was fatal. An immunodeficient patient with pneumonia had the vaccine strain of VZV in a lung biopsy. Pregnant women occasionally received varicella vaccine through confusion with varicella zoster immunoglobulin. Although the role of varicella vaccine remained unproven in most serious adverse event reports, there were a few positive rechallenge reports and consistency of many cases with syndromes recognized as complications of natural varicella.Conclusion: Most of the reported adverse events associated with varicella vaccine are minor, and serious risks appear to be rare. We could not confirm a vaccine etiology for most of the reported serious events; several will require further study to clarify whether varicella vaccine plays a role. Education is needed to ensure appropriate use of varicella serologic assays and to eliminate confusion between varicella vaccine and varicella zoster immunoglobulin. JAMA. 2000;284:1271-1279
SN - 0098-7484
AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, FDA CBER HFM-225, Rockville, MD 20852-1448, USA
AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 10979114.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106989292
T1 - Who receives Ryan White CARE Act Services? A demographic comparison of CARE Act clients and the general AIDS population.
AU - Ashman JJ
AU - Marconi KM
AU - McKinney MM
AU - O'Neill JF
Y1 - 2000/10//
N1 - Accession Number: 106989292. Language: English. Entry Date: 20010112. Revision Date: 20150818. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - Medically Uninsured -- United States
KW - Financing, Government -- United States
KW - Acquired Immunodeficiency Syndrome
KW - Health Resource Utilization -- United States
KW - United States
KW - Grants
KW - Acquired Immunodeficiency Syndrome -- Epidemiology
KW - Geographic Factors
KW - Chi Square Test
KW - Sex Factors
KW - Race Factors
KW - Descriptive Statistics
KW - Centers for Disease Control and Prevention (U.S.)
KW - Record Review
KW - Descriptive Research
KW - Convenience Sample
KW - Male
KW - Female
KW - Human
SP - 561
EP - 565
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 14
IS - 10
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
AD - HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 7A-07, Rockville, MD 20857; Jashman@hrsa.gov
U2 - PMID: 11054941.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cecala, Andrew B.
AU - Timko, Robert J.
AU - Thimons, Edward D.
T1 - Methods to Lower the Dust Exposure of Bag Machine Operators and Bag Stackers.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/10//
VL - 15
IS - 10
M3 - Article
SP - 751
EP - 765
PB - Taylor & Francis Ltd
SN - 1047322X
AB - This article reviews various dust control technologies developed over the years at the Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH) to provide various options and alternatives to lower bag machine operators' and bag stackers' dust exposures. Dust exposure records for the past 20 years show that bag machine operators and bag stackers normally have the highest respirable dust exposures of workers at mineral processing plants. A substantial amount of research has been performed over the years to minimize the dust exposure to these workers and the intent is to present all this information together in one article. Most of the research describes engineering controls that were adapted to existing facilities to reduce the dust generated during bag filling, bag conveying, and bag stacking. In some cases, a single technique succeeded in lowering respirable dust concentrations for all three processes, thus reducing the dust exposure to both the bag machine operator and the bag stacker. In other cases, a technique was developed to specifically reduce the dust exposure of one process or the other.This research also reviews various controls for secondary dust exposure, including general ventilation requirements to mill buildings, the effects of background dust sources, and personal work practices. This information is presented to help industrial hygienists, plant managers, engineers, and workers lower the dust exposure of bag machine operators and bag stackers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dust control
KW - Health
KW - Silica
KW - Pennsylvania
KW - Pittsburgh (Pa.)
KW - United States
KW - BAG OPERATOR
KW - BAG STACKER
KW - Dust exposure
KW - Mineral processing
KW - Respirable dust
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 3961938; Cecala, Andrew B. 1; Timko, Robert J. 1; Thimons, Edward D. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; Issue Info: Oct2000, Vol. 15 Issue 10, p751; Thesaurus Term: Dust control; Thesaurus Term: Health; Subject Term: Silica; Subject: Pennsylvania; Subject: Pittsburgh (Pa.); Subject: United States; Author-Supplied Keyword: BAG OPERATOR; Author-Supplied Keyword: BAG STACKER; Author-Supplied Keyword: Dust exposure; Author-Supplied Keyword: Mineral processing; Author-Supplied Keyword: Respirable dust ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 15p; Illustrations: 2 Black and White Photographs, 4 Diagrams, 3 Charts, 10 Graphs; Document Type: Article
L3 - 10.1080/10473220050129392
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DB - eih
ER -
TY - JOUR
AU - Ma, J.Y.C.
AU - Barger, M.W.
AU - Kriech, A.J.
AU - Castranova, V.
T1 - Effects of asphalt fume condensate exposure on acute pulmonary responses.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2000/10//
VL - 74
IS - 8
M3 - Article
SP - 452
EP - 459
PB - Springer Science & Business Media B.V.
SN - 03405761
AB - Objective: The present study was carried out to characterize the effects of in vitro exposure to paving asphalt fume condensate (AFC) on alveolar macrophage (AM) functions and to monitor acute pulmonary responses to in vivo AFC exposure in rats. Methods: For in vitro studies, rat primary AM cultures were incubated with various concentrations of AFC for 24 h at 37°C. AM-conditioned medium was collected and assayed for lactate dehydrogenase (LDH) as a marker of cytotoxicity. Tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) production were assayed in AM-conditioned medium to monitor AM function. The effect of AFC on chemiluminescence (CL) generated by resting AM or AM in response to zymosan or PMA stimulation was also determined as a marker of AM activity. For in vivo studies, rats received either (1) a single intratracheal (IT) instillation of saline, or 0.1 mg or 0.5 mg AFC and were killed 1 or 3 days later; or (2) IT instillation of saline, or 0.1, 0.5, or 2 mg AFC for three consecutive days and were killed the following day. Differential counts of cells harvested by bronchoalveolar lavage were measured to monitor inflammation. Acellular LDH and protein content in the first lavage fluid were measured to monitor damage. CL generation, TNF-α and IL-1 production by AM were assayed to monitor AM function. Results: In vitro AFC exposure at <200 µg/ml did not induce cytotoxicity, oxidant generation, or IL-1 production by AM, but it did cause a small but significant increase in TNF-α release from AM. In vitro exposure of AM to AFC resulted in a significant decline of CL in response to zymosan or PMA stimulation. The in vivo studies showed that AFC exposure did not induce significant neutrophil infiltration or alter LDH or protein content in acellular lavage samples. Macrophages obtained from AFC-exposed rats did not show significant differences in oxidant production or cytokine secretion at rest or in response to LPS in comparison with control macrophages. Conclusions: These results suggest that: (1) in vitro AFC exposure did not adversely affect cell viability or induce the release of high levels of inflammatory cytokines or oxidants; and (2) exposure of rats to AFC did not cause acute pulmonary inflammation or injury, and did not significantly alter AM functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Asphalt
KW - Macrophages
KW - Adult respiratory distress syndrome
KW - Rats
KW - Tumor necrosis factor
KW - Chemiluminescence
KW - Alveolar macrophage
KW - Asphalt fume condensate
KW - Lung injury
KW - Paving asphalt
KW - Pulmonary inflammation
N1 - Accession Number: 15731725; Ma, J.Y.C. 1; Email Address: jym1@cdc.gov; Barger, M.W. 1; Kriech, A.J. 2; Castranova, V. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, USA; 2: Heritage Research Group, Indianapolis, Indiana 46231, USA; Issue Info: Oct2000, Vol. 74 Issue 8, p452; Thesaurus Term: Air pollution; Thesaurus Term: Asphalt; Subject Term: Macrophages; Subject Term: Adult respiratory distress syndrome; Subject Term: Rats; Subject Term: Tumor necrosis factor; Subject Term: Chemiluminescence; Author-Supplied Keyword: Alveolar macrophage; Author-Supplied Keyword: Asphalt fume condensate; Author-Supplied Keyword: Lung injury; Author-Supplied Keyword: Paving asphalt; Author-Supplied Keyword: Pulmonary inflammation; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/s002040000145
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ER -
TY - JOUR
ID - 107003790
T1 - Asthma-like symptoms in wood product plant workers exposed to methylene diphenyl diisocyanate.
AU - Petsonk EL
AU - Wang ML
AU - Lewis DM
AU - Siegel PD
AU - Husberg BJ
Y1 - 2000/10//
N1 - Accession Number: 107003790. Language: English. Entry Date: 20010302. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Institute for Occupational Safety and Health. NLM UID: 0231335.
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Diseases -- Etiology
KW - Asthma -- Etiology
KW - Organic Chemicals -- Adverse Effects
KW - Occupational Health
KW - Work Environment
KW - Spirometry
KW - Forced Expiratory Volume
KW - Prevalence
KW - Skin Tests
KW - Questionnaires
KW - Data Analysis Software
KW - Odds Ratio
KW - Confidence Intervals
KW - Chi Square Test
KW - T-Tests
KW - Logistic Regression
KW - Funding Source
KW - Human
SP - 1183
EP - 1193
JO - CHEST
JF - CHEST
JA - CHEST
VL - 118
IS - 4
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - BACKGROUND: Diisocyanates, a group of highly reactive chemicals, have frequently been associated with occupational asthma. We evaluated respiratory health in workers at a new wood products manufacturing plant that uses methylene diphenyl diisocyanate (MDI), and was designed and operated with a goal of minimizing worker exposures. METHODS: Health surveys using standardized respiratory questionnaires were done prior to the initial use of diisocyanates in the plant, and semiannually thereafter for a period of 2 years. Other testing included occupational and work practice histories, serial peak flow measurements, spirometry, methacholine challenge, and measurement of specific IgE antibodies to MDI-albumin conjugate. RESULTS: Of 214 plant employees who participated in at least one health survey, a follow-up survey was also available from 178 employees (83%). New-onset asthma-like symptoms (NAS) were reported by 15 of 56 workers (27%) in areas with the highest potential for exposures to liquid MDI monomer and prepolymer, vs 0 of 43 workers in the lowest potential exposure areas (p = 0.001). In the areas with high potential exposure, NAS developed in 47% of workers who had noted MDI skin staining, vs 19% without skin stains (p = 0.07). Working around and cleaning up liquid MDI represented a significant risk for asthma-like symptoms in both current smokers and nonsmokers; work with finished wood products did not. Asthma-like symptoms were associated with variable airflow limitation (odds ratio [OR], 5.0; confidence interval [CI], 1.4 to 18.7) and specific IgE to MDI-albumin (OR, 3.2; CI, 1.1 to 9.0), but not with skin prick tests to common aeroallergens (OR, 1.1; CI, 0.5 to 2.7). CONCLUSIONS: During the first 2 years of operation, in a plant designed and operated to control exposure to diisocyanates, the development of asthma-like symptoms was reported in a relatively high proportion of the employees who worked with liquid MDI. To prevent asthma symptoms among workers, careful control of respiratory tract exposures associated with liquid MDI is important, especially during cleanup activities. Strict limitation of skin contact with diisocyanates may also be necessary.
SN - 0012-3692
AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505-2888
U2 - PMID: 11035694.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Petsonk, Edward L.
AU - Mei Lin Wang, Edward L.
AU - Lewis, Daniel M.
AU - Siegel, Paul D.
AU - Husberg, Bradley J.
T1 - Asthma-Like Symptoms in Wood Product Plant Workers Exposed to Methylene Diphenyl Diisocyanate.
JO - CHEST
JF - CHEST
Y1 - 2000/10//
VL - 118
IS - 4
M3 - Article
SP - 1183
PB - American College of Chest Physicians
SN - 00123692
AB - Background: Diisocyanates, a group of highly reactive chemicals, have frequently been associated with occupational asthma. We evaluated respiratory health in workers at a new wood products manufacturing plant that uses methylene diphenyl diisocyanate (MDI), and was designed and operated with a goal of minimizing worker exposures. Methods: Health surveys using standardized respiratory questionnaires were done prior to the initial use of diisocyanates in the plant, and semiannually thereafter for a period of 2 years. Other testing included occupational and work practice histories, serial peak flow measurements, spirometry, methacholine challenge, and measurement of specific IgE antibodies to MDI-albumin conjugate. Results: Of 214 plant employees who participated in at least one health survey, a follow-up survey was also available from 178 employees (83%). New-onset asthma-like symptoms (NAS) were reported by 15 of 56 workers (27%) in areas with the highest potential for exposures to liquid MDI monomer and prepolymer, vs 0 of 43 workers in the lowest potential exposure areas (p = 0.001). In the areas with high potential exposure, NAS developed in 47% of workers who had noted MDI skin staining, vs 19% without skin stains (p = 0.07). Working around and cleaning up liquid MDI represented a significant risk for asthma-like symptoms in both current smokers and nonsmokers; work with finished wood products did not. Asthma-like symptoms were associated with variable airflow limitation (odds ratio [OR], 5.0; confidence interval ICI], 1.4 to 18.7) and specific IgE to MDI-albumin (OR, 3.2; CI, 1.1 to 9.0), but not with skin prick tests to common aeroallergens (OR, 1.1; CI, 0.5 to 2.7). Conclusions: During the first 2 years of operation, in a plant designed and operated to control exposure to diisocyanates, the development of asthma-like symptoms was reported in a relatively high proportion of the employees who worked with liquid MDI. To prevent asthma symptoms among workers, careful control of respiratory tract exposures associated with liquid MDI is important, especially during cleanup activities. Strict limitation of skin contact with diisocyanates may also be necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL diseases
KW - LUNG diseases
KW - ISOCYANATES
KW - ASTHMA
N1 - Accession Number: 11005011; Petsonk, Edward L. 1; Mei Lin Wang, Edward L. 1; Lewis, Daniel M. 2; Siegel, Paul D. 2; Husberg, Bradley J. 1; Source Information: Oct2000, Vol. 118 Issue 4, p1183; Subject: OCCUPATIONAL diseases; Subject: LUNG diseases; Subject: ISOCYANATES; Subject: ASTHMA; Number of Pages: 11p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Lawn, S. D.
AU - Rudolph, D.
AU - Wiktor, S.
AU - Coulibaly, D.
AU - Ackah, A.
AU - Lal, R. B.
T1 - Tuberculosis (TB) and HIV infection are independently associated with elevated serum concentrations of tumour necrosis factor receptor type 1 and β2-microglobulin, respectively.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2000/10//
VL - 122
IS - 1
M3 - Article
SP - 79
EP - 84
SN - 00099104
AB - The aim of this study was to identify immune markers that are independently associated with HIV infection or TB in vivo. Using commercially available assays, we measured concentrations of five immune markers in sera from 175 out-patients attending medical clinics in Cote D'Ivoire and Ghana, West Africa. Patients were categorized into groups with TB only (TB+HIV-, n = 55), TB and HIV co-infection (TB+HIV+, n = 50), HIV infection only (TB-HIV+, n = 35), or neither infection (TB-HIV-, n = 35). TB+HIV+ and TB-HIV+ groups were matched for blood CD4+ lymphocyte count. Mean ± s.d. concentrations of β2-microglobulin were similarly increased in both the TB-HIV+ (5·3 ± 2·1 μg/ml, P < 0·0001) and the TB+HIV+ (5·0 ± 1·5 μg/ml, P < 0·0001) groups compared with the TB-HIV- group (2·2 ± 1·8 μg/ml), but were only slightly increased in the TB+HIV- group (3·2 ± 1·8 μg/ml, P = 0·01). In contrast, mean serum concentrations of soluble tumour necrosis factor receptor type I (sTNF-RI) were similarly elevated in the TB+HIV- (1873 ± 799 pg/ml, P < 0·0001) and TB+HIV+ (1797 ± 571 pg/ml, P < 0·0001) groups compared with uninfected subjects (906 ± 613 pg/ml), but there was only a small increase in sTNF-RI in the TB-HIV+ group (1231 ± 165 pg/ml, P = 0·03). Both TB and HIV infection were associated with substantial elevation of serum concentrations of soluble CD8, soluble CD54, and sTNF-R type II. Analysis of additional samples from groups of TB+HIV- and TB+HIV+ patients receiving anti-TB treatment... [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - TUBERCULOSIS
KW - HIV infections
KW - SERUM
KW - GLOBULINS
KW - β
KW - HIV
KW - immune activation markers
KW - TNF receptors
KW - tuberculosis
N1 - Accession Number: 5465881; Lawn, S. D. 1; Rudolph, D. 1; Wiktor, S. 2; Coulibaly, D. 2; Ackah, A. 2; Lal, R. B. 1; Source Information: Oct2000, Vol. 122 Issue 1, p79; Subject: TUMOR necrosis factor; Subject: TUBERCULOSIS; Subject: HIV infections; Subject: SERUM; Subject: GLOBULINS; Author-Supplied Keyword: β; Author-Supplied Keyword: HIV; Author-Supplied Keyword: immune activation markers; Author-Supplied Keyword: TNF receptors; Author-Supplied Keyword: tuberculosis; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2249.2000.01341.x
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DB - hch
ER -
TY - JOUR
ID - 89447228
T1 - Phase I assessment of the pharmacokinetics, metabolism, and safety of emitefur in patients with refractory solid tumors.
AU - Nemunaitis, J.
AU - Eager, R.
AU - Twaddell, T.
AU - Corey, A.
AU - Sekar, K.
AU - Tkaczuk, K.
AU - Thompson, J.
AU - Hoff, P. M.
AU - Pazdur, R.
Y1 - 2000/10//10/1/2000
N1 - Accession Number: 89447228. Language: English. Entry Date: 20010202. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Profile of Mood States (POMS); Defining Issues Test (DIT) (Rest). NLM UID: 8309333.
KW - Neoplasms -- Metabolism
KW - Antineoplastic Agents -- Adverse Effects
KW - Fluorouracil -- Pharmacokinetics
KW - Fluorouracil -- Analogs and Derivatives
KW - Fluorouracil -- Adverse Effects
KW - Neoplasms -- Drug Therapy
KW - Antineoplastic Agents -- Pharmacokinetics
KW - Dose-Response Relationship, Drug
KW - Male
KW - Adult
KW - Antineoplastic Agents -- Therapeutic Use
KW - Aged
KW - Fluorouracil -- Therapeutic Use
KW - Human
KW - Middle Age
KW - Female
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 3423
EP - 3434
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 18
IS - 19
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: To determine the toxicities, dose-limiting toxicities (DLT), maximum-tolerated dose, and pharmacokinetic profile of emitefur (BOF-A2) in patients with advanced solid tumors.Methods: This was a phase I dose-escalating trial in which cohorts of patients received BOF-A2 (cohort 1, 300 mg/m(2) orally [PO] tid; cohort 2, 200 mg/m(2) PO tid; cohort 3, 200 mg/m(2) bid; and cohort 4, 250 mg/m(2) bid) for 14 consecutive days followed by 1 week of rest (cycle 1). Pharmacokinetics, toxicity, and tumor response were monitored.Results: Nineteen patients received 110 cycles (three patients in cohort 1, three patients in cohort 2, 10 patients in cohort 3, and three patients in cohort 4). DLT (grade 3 stomatitis, diarrhea, leukopenia) was observed in cohorts 1, 2, and 4. Pharmacokinetics indicated that prolonged systemic expression of fluorouracil (5-FU) is maintained after administration of BOF-A2 at a dose of 200 mg bid for 14 days. The mean steady-state concentration of plasma 5-FU was > or = 24 ng/mL, which was 184-fold greater than the minimum effective cytotoxic concentration in vitro. Lack of variation of 5-FU trough levels within a day at steady-state indicates suppression of circadian variation. One patient in cohort 3 achieved a partial response and five patients maintained stable disease in excess of 6 months.Conclusion: BOF-A2 at a dose of 200 mg PO bid for 14 days followed by 7 days of rest is well tolerated. Prolonged exposure to 5-FU above the predicted preclinical minimum effective concentration is maintained, without evidence of circadian variation. Furthermore, evidence of antitumor activity is suggested.
SN - 0732-183X
AD - US Oncology
AD - Sammons Cancer Center, Baylor University Medical Center
AD - Mary Crowley Medical Research Center, Dallas
AD - M.D. Anderson Cancer Center, Houston, TX
AD - Otsuka America Pharmaceutical, Inc., Palo Alto, CA
AD - Otsuka America Pharmaceutical, Inc.
AD - United States Food and Drug Administration, Division of Oncology Drug Products, Rockville
AD - University of Maryland Greenbaum Cancer Center, Baltimore, MD
AD - University of Washington Medical Center, Seattle, WA
U2 - PMID: 11013283.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107032433
T1 - The promises and reality of cosmetics.
AU - Bradbard L
Y1 - 2000/10//2000 Oct
N1 - Accession Number: 107032433. Language: English. Entry Date: 20010622. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 100960576.
KW - Cosmetics
KW - Hypersensitivity
KW - Skin Care
KW - Safety
SP - 32
EP - 34
JO - Sickbay Today
JF - Sickbay Today
JA - SICKBAY TODAY
CY - Melvile, New York
PB - Sickbay Health Media
AB - Cosmetics can't work miracles, but they can help keep your skin clean and looking moist and soft. They also can temporarily close pores, plump up skin to make it appear smoother, and give you a rosy glow or blush.
AD - Staff Member, US Food and Drug Administration
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DB - rzh
ER -
TY - JOUR
ID - 89431085
T1 - Phase I study of preoperative oral uracil and tegafur plus leucovorin and radiation therapy in rectal cancer.
AU - Hoff, Paulo M.
AU - Janjan, Nora
AU - Saad, Everardo D.
AU - Skibber, John
AU - Crane, Christopher
AU - Lassere, Yvonne
AU - Cleary, Karen R.
AU - Benner, Steve
AU - Randolph, Jacqueline
AU - Abbruzzese, James L.
AU - Pazdur, Richard
AU - Hoff, P M
AU - Janjan, N
AU - Saad, E D
AU - Skibber, J
AU - Crane, C
AU - Lassere, Y
AU - Cleary, K R
AU - Benner, S
AU - Randolph, J
Y1 - 2000/10/15/
N1 - Accession Number: 89431085. Language: English. Entry Date: 20010216. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Antineoplastic Agents, Combined -- Adverse Effects
KW - Rectal Neoplasms -- Therapy
KW - Heterocyclic Compounds -- Administration and Dosage
KW - Leucovorin -- Adverse Effects
KW - Drug Administration Schedule
KW - Rectal Neoplasms -- Drug Therapy
KW - Surgery, Operative
KW - Leucovorin -- Administration and Dosage
KW - Fluorouracil -- Administration and Dosage
KW - Adult
KW - Fluorouracil -- Adverse Effects
KW - Rectal Neoplasms -- Radiotherapy
KW - Heterocyclic Compounds -- Adverse Effects
KW - Administration, Oral
KW - Female
KW - Male
KW - Combined Modality Therapy
KW - Preoperative Care
KW - Postoperative Care
KW - Rectal Neoplasms -- Surgery
KW - Middle Age
KW - Aged
KW - Human
KW - Antineoplastic Agents, Combined -- Administration and Dosage
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 3529
EP - 3534
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 18
IS - 20
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: Preoperative combined-modality therapy for rectal cancer may allow for sphincter preservation, while decreasing recurrence rates and improving the overall prognosis. Oral chemotherapy with uracil and tegafur (UFT) plus leucovorin (LV) may reduce costs and complications associated with protracted infusions of fluorouracil. Our goal was to evaluate the safety of UFT plus LV combined with preoperative radiation and determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of UFT plus LV in this setting.Patients and Methods: Patients with tumor-node-metastasis stage II or III rectal cancer received escalating doses of UFT (starting at 250mg/m(2)/d, with 50-mg/m(2)/d increments between consecutive cohorts) and fixed doses of LV (90 mg/d). The UFT and LV combination was given 5 days per week concurrently with a 5-week course of preoperative radiation totaling 45 Gy (1.8 Gy/fraction). Surgery was performed 4 to 6 weeks after radiation and was followed by four 35-day cycles of fixed doses of UFT and LV (28 days of therapy each cycle).Results: Fifteen patients were treated, and 13 received the full preoperative chemotherapy. All planned radiation was delivered successfully. The MTD of UFT with radiation was 350 mg/m(2)/d with 90 mg/d of LV. Diarrhea was the DLT. Sphincter-preserving surgery was performed in 12 of 14 patients. One patient had progressive disease before surgery. Pathologic evaluation of 14 resected specimens showed a complete response in three cases.Conclusion: Preoperative chemoradiation with oral UFT plus LV is feasible and well tolerated and should be further investigated.
SN - 0732-183X
AD - Departments of Gastrointestinal Medical Oncology and Digestive Diseases, Radiation Oncology, Surgical Oncology, and Pathology, The University of Texas M. D.
AD - Anderson Cancer Center, Houston, TX
AD - Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ
AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
AD - Departments of Gastrointestinal Medical Oncology and Digestive Diseases, Radiation Oncology, Surgical Oncology, and Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
U2 - PMID: 11032595.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Eisenberg, John M.
AU - Power, Elaine J.
AU - Eisenberg, J M
AU - Power, E J
T1 - Transforming insurance coverage into quality health care: voltage drops from potential to delivered quality.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2000/10/25/
VL - 284
IS - 16
M3 - journal article
SP - 2100
EP - 2107
SN - 00987484
AB - Although the US health care system is often touted as one of the best in the world, disparities exist in quality of care received by different populations, in different regions, and across different institutions and clinicians. Initiatives to provide access to health insurance have been a major policy tool to ensure that Americans receive high-quality health care. However, availability of insurance coverage does not automatically lead to high-quality care. This article explores points of vulnerability in the US health care system at which the potential to achieve high-quality care can be lost: (1) access to insurance coverage; (2) enrollment in available insurance plans; (3) access to covered services, clinicians, and health care institutions; (4) choice of plans, clinicians, and health care institutions; (5) access to a consistent source of primary care; (6) access to referral services; and (7) delivery of high-quality health care services. Ensuring high-quality health care requires that each of these "voltage drops" be recognized and addressed. JAMA. 2000;284:2100-2107. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- United States
KW - HEALTH insurance -- United States
KW - NEEDS assessment (Medical care)
KW - QUALITY control
KW - UNITED States
N1 - Accession Number: 3689159; Eisenberg, John M.; Power, Elaine J.; Eisenberg, J M 1; Power, E J; Source Information: 10/25/2000, Vol. 284 Issue 16, p2100; Subject: MEDICAL care -- United States; Subject: HEALTH insurance -- United States; Subject: NEEDS assessment (Medical care); Subject: QUALITY control; Geographic Terms: UNITED States; Number of Pages: 8p; Illustrations: 1 Diagram; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107010253
T1 - Hormone replacement therapy was associated with increased venous thromboembolism and deep venous thrombosis...commentary on Grady D, Wenger NK, Herrington D, et al., for the Heart and Estrogen/progestin Replacement Study Research Group. Postmenopausal hormone therapy increases risk for venous thromboembolic disease: the Heart and Estrogen/progestin Replacement Study. ANN INTERN MED 2000 May 2;132:689-96
AU - Atkins D
AU - Miller J
Y1 - 2000/11//2000 Nov-Dec
N1 - Accession Number: 107010253. Language: English. Entry Date: 20010330. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Hormone Replacement Therapy -- Adverse Effects
KW - Estrogens -- Adverse Effects
KW - Medroxyprogesterone -- Adverse Effects
KW - Venous Thrombosis -- Chemically Induced
KW - Thromboembolism -- Chemically Induced
KW - Venous Thromboembolism
KW - Coronary Disease -- Complications
KW - Double-Blind Studies
KW - Prospective Studies
KW - Treatment Outcomes
KW - Pulmonary Embolism -- Chemically Induced
KW - Confidence Intervals
KW - Risk Factors
KW - Age Factors
KW - Sex Factors
KW - Adult
KW - Middle Age
KW - Aged
KW - Female
KW - Outpatients
KW - United States
SP - 106
EP - 106
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 133
IS - 3
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Agency for Healthcare Research and Quality, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Morrow-Howell, N. L.
AU - Proctor, E. K.
AU - Rubin, E. H.
AU - Li, H.
AU - Thompson, S.
T1 - Service needs of depressed older adults following acute psychiatric care.
JO - Aging & Mental Health
JF - Aging & Mental Health
Y1 - 2000/11//
VL - 4
IS - 4
M3 - Article
SP - 330
EP - 338
PB - Routledge
SN - 13607863
AB - Older persons with mental disorder need mental health services, but the extent to which they have service needs in other domains (medical, functional and psychosocial) is not established, although these needs may compromise the attainment of psychiatric outcomes. This study focuses on 169 older adults hospitalized for depression and documents their post-acute service needs in four domains: psychiatric, medical, functional and psychosocial. Seventy-five per cent of these psychiatric patients had medical conditions that required treatment. Eighty-four per cent needed assistance with routine activities. Nearly two-thirds (67%) were experiencing one or more psychosocial or environmental problems that warranted intervention. The mean number of service needs was 6.5 (SD=1.5). Fifty-seven per cent had needs in all four domains. Older adults admitted to acute care for depression have high levels of service needs stemming from multiple domains: psychiatric, medical, functional and psychosocial. We extend the biopsychosocial model, largely used to address the origins of psychopathology, to conceptualize the multiple domains of service that older adults with mental disorder need. This biopsychosocial model suggests that needs in each domain should be identified and addressed if desired psychiatric outcomes are to be attained. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aging & Mental Health is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health services
KW - DEPRESSED persons
KW - UNITED States
N1 - Accession Number: 4176421; Morrow-Howell, N. L. 1; Proctor, E. K. 1; Rubin, E. H. 2; Li, H. 3; Thompson, S. 4; Source Information: Nov2000, Vol. 4 Issue 4, p330; Subject: MENTAL health services; Subject: DEPRESSED persons; Geographic Terms: UNITED States; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6074
L3 - 10.1080/13607860020010484
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107005470
T1 - Service needs of depressed older adults following acute psychiatric care.
AU - Morrow-Howell NL
AU - Proctor EK
AU - Rubin EH
AU - Li H
AU - Thompson S
Y1 - 2000/11//
N1 - Accession Number: 107005470. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: OARS Multidimensional Functional Assessment Questionnaire (OMFAQ); Mini-Mental Status Examination (MMSE) (Folstein et al); Chronic Illness Rating Scale-Geriatric (CIRS-G). Grant Information: Supported by the Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St Louis through an award from the National Institute of Mental Health (#1R01MH56208). NLM UID: 9705773.
KW - After Care -- In Old Age
KW - Health Services for the Aged
KW - Geriatric Functional Assessment
KW - Mental Disorders -- Rehabilitation -- In Old Age
KW - OARS Multidimensional Functional Assessment Questionnaire
KW - Descriptive Statistics
KW - Needs Assessment
KW - Interviews
KW - Scales
KW - Psychiatric Patients
KW - Aged, Hospitalized
KW - Funding Source
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 330
EP - 338
JO - Aging & Mental Health
JF - Aging & Mental Health
JA - AGING MENT HEALTH
VL - 4
IS - 4
CY - Oxfordshire,
PB - Routledge
AB - Older persons with mental disorder need mental health services, but the extent to which they have service needs in other domains (medical, functional and psychosocial) is not established, although these needs may compromise the attainment of psychiatric outcomes. This study focuses on 169 older adults hospitalized for depression and documents their post-acute service needs in four domains: psychiatric, medical, functional and psychosocial. Seventy-five per cent of these psychiatric patients had medical conditions that required treatment. Eighty-four per cent needed assistance with routine activities. Nearly two-thirds (67%) were experiencing one or more psychosocial or environmental problems that warranted intervention. The mean number of service needs was 6.5 (SD=1.5). Fifty-seven per cent had needs in all four domains. Older adults admitted to acute care for depression have high levels of service needs stemming from multiple domains: psychiatric, medical, functional and psychosocial. We extend the biopsychosocial model, largely used to address the origins of psychopathology, to conceptualize the multiple domains of service that older adults with mental disorder need. This biopsychosocial model suggests that needs in each domain should be identified and addressed if desired psychiatric outcomes are to be attained.
SN - 1360-7863
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Campus Box 1196, Washington University, St Louis, Missouri 63130. E-mail: nancymh@gwbmail.wustl.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107069317
T1 - Racial/ethnic differences in children's access to care.
AU - Weinick RM
AU - Krauss NA
Y1 - 2000/11//
N1 - Accession Number: 107069317. Language: English. Entry Date: 20011123. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Health Services Accessibility -- Evaluation -- In Infancy and Childhood
KW - Race Factors
KW - Child Health Services
KW - Exploratory Research
KW - Surveys
KW - Descriptive Statistics
KW - Logistic Regression
KW - Odds Ratio
KW - P-Value
KW - Insurance, Health
KW - Socioeconomic Factors
KW - Whites
KW - Blacks
KW - Hispanics
KW - Asians
KW - Health Policy
KW - Infant, Newborn
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Male
KW - Female
KW - Human
SP - 1771
EP - 1774
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 90
IS - 11
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study explored reasons for racial and ethnic differences in children's usual sources of care. METHODS: Data from the 1996 Medical Expenditure Panel Survey were examined by means of logistic regression techniques. RESULTS: Black and Hispanic children were substantially less likely than White children to have a usual source of care. These differences persisted after control for health insurance and socioeconomic status. Control for language ability, however, eliminated differences between Hispanic and White children. CONCLUSIONS: Results suggest that the marked Hispanic disadvantage in children's access to care noted in earlier studies may be related to language ability.
SN - 0090-0036
AD - Center for Primary Care Research, Agency for Healthcare Research and Quality, 2101 E Jefferson St, Rockville, MD 20852 (rweinick@ahrq.gov)
U2 - PMID: 11076248.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Racial/Ethnic Differences in Children's Access to Care.
AU - Weinick, Robin M.
AU - Krauss, Nancy A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/11//
VL - 90
IS - 11
SP - 1771
EP - 1774
SN - 00900036
N1 - Accession Number: 3738283; Author: Weinick, Robin M.: 1 email: rweinick@ahrq.gov. Author: Krauss, Nancy A.: 1 ; Author Affiliation: 1 Agency for Healthcare Research and Quality, Rockville, Md.; No. of Pages: 4; Language: English; Publication Type: Article; Update Code: 20060612
N2 - Objectives. This study explored reasons for racial and ethnic differences in children's usual sources of care. Methods. Data from the 1996 Medical Expenditure Panel Survey were examined by means of logistic regression techniques. Results. Black and Hispanic children were substantially less likely than White children to have a usual source of care. These differences persisted after control for health insurance and socioeconomic status. Control for language ability, however, eliminated differences between Hispanic and White children. Conclusions. Results suggest that the marked Hispanic disadvantage in children's access to care noted in earlier studies may be related to language ability. (Am d Public Health. 2000;90: 1771-1774) ABSTRACT FROM AUTHOR
KW - RACIAL differences
KW - ETHNICITY
KW - CHILD care
KW - SURVEYS
KW - LOGISTIC regression analysis
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - BROUWER, DERK H.
AU - BOENIGER, MARK F.
AU - HEMMEN, JOOP VAN
T1 - Hand Wash and Manual Skin Wipes.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2000/11//
VL - 44
IS - 7
M3 - Article
SP - 501
EP - 510
SN - 00034878
AB - Hand wash and skin wipes are major techniques that have been used for dermal exposure sampling. Both techniques remove chemicals either deposited on or transferred to the skin contaminant layer by a combination of chemical and mechanical actions. The paper overviews identified methods and techniques, with emphasis on sampling parameters and sampling efficiency. It is concluded that identified sampling protocols, including sampling techniques, deviate at possible key issues, which hampers comparisons of study results. It is recommended to conduct sampling efficiency studies prior to field sampling, under conditions that are quite similar to conditions of exposure regarding exposure process, levels of skin loading, and time of residence of the compound on the skin. Harmonization of sampling protocols will be a first step in creating a database for better understanding the influence of sampling parameters on the performance of removal techniques to assess dermal exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pollutants
KW - Physiology
KW - Contamination (Technology)
KW - Hand washing
KW - Chemicals
KW - Hygiene
KW - Databases
KW - Dermatology
KW - Skin care
KW - pesticides
KW - skin exposure
KW - washing
KW - wiping
N1 - Accession Number: 45226792; BROUWER, DERK H. 1; Email Address: brouwer@voeding.tno.nl; BOENIGER, MARK F. 2; HEMMEN, JOOP VAN 1; Affiliations: 1: TNO Nutrition and Food Research, Department of Chemical Exposure Assessment, P.O. Box 360, 3700 AJ Zeist, The Netherlands.; 2: National Institute of Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Mail Stop R-14, Cincinnati, OH, USA.; Issue Info: Nov2000, Vol. 44 Issue 7, p501; Thesaurus Term: Pollutants; Thesaurus Term: Physiology; Thesaurus Term: Contamination (Technology); Subject Term: Hand washing; Subject Term: Chemicals; Subject Term: Hygiene; Subject Term: Databases; Subject Term: Dermatology; Subject Term: Skin care; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: skin exposure; Author-Supplied Keyword: washing; Author-Supplied Keyword: wiping; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 10p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Sietmann, Rabea
AU - Hammer, Elke
AU - Moody, Joanna
AU - Cerniglia, Carl E.
AU - Schauer, Frieder
T1 - Hydroxylation of biphenyl by the yeast Trichosporon mucoides.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2000/11//
VL - 174
IS - 5
M3 - Article
SP - 353
EP - 361
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - Hydroxylation of biphenyl by the dibenzofuran-degrading yeast Trichosporon mucoides SBUG 801 was studied. Glucose-grown cells degraded 40% of the biphenyl added within the first 24 h of incubation. The first step in the biotransformation pathway was the monohydroxylation of the biaryl compound to produce 2-, 3-, and 4-hydroxybiphenyl. Further oxidation produced seven dihydroxylated intermediates; the second hydroxyl group was added either on the aromatic ring already hydroxylated or on the second ring. Of all metabolites, 2,5-dihydroxybiphenyl accumulated in the supernatant in the highest concentration. The initial hydroxylation favors the 4-position to produce 4-hydroxybiphenyl, which is subsequently hydroxylated to form 3,4-dihydroxybiphenyl. When biphenyl was replaced as a substrate by 4-hydroxybiphenyl, further hydroxylation of the intermediate 3,4-dihydroxybiphenyl resulted in 3,4,4′-trihydroxybiphenyl. Incubation of T. mucoides with biphenyl and 18O2 indicated a monooxygenase-catalyzed reaction in the oxidation of biphenyl. The hydroxylation was inhibited by 1-aminobenzotriazole and metyrapone, known cytochrome P450 inhibitors. These results are very similar to those observed in the biotransformation of biphenyl in mammals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biphenyl compounds
KW - Cytochrome P-450
KW - Microorganisms
KW - Microbiology
KW - Hydroxylation
KW - Yeast
KW - Microbiological research
KW - Cytochrome P450
KW - Trichosporon
KW - Trichosporon Cytochrome P450
N1 - Accession Number: 15731313; Sietmann, Rabea 1; Email Address: sietmann@microbio1.biologie.uni-greifswald.de; Hammer, Elke 1; Moody, Joanna 2; Cerniglia, Carl E. 2; Schauer, Frieder 1; Affiliations: 1: Institut für Mikrobiologie und Molekularbiologie, Ernst-Moritz-Arndt-Universität, F.-L.-Jahn-Strasse 15, 17489 Greifswald, Germany; 2: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AK 720792, USA; Issue Info: Nov2000, Vol. 174 Issue 5, p353; Thesaurus Term: Biphenyl compounds; Thesaurus Term: Cytochrome P-450; Thesaurus Term: Microorganisms; Thesaurus Term: Microbiology; Subject Term: Hydroxylation; Subject Term: Yeast; Subject Term: Microbiological research; Author-Supplied Keyword: Cytochrome P450; Author-Supplied Keyword: Trichosporon; Author-Supplied Keyword: Trichosporon Cytochrome P450; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s002030000219
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DB - eih
ER -
TY - JOUR
AU - Antonini, James M.
AU - Yang, Hui-Min
AU - Ma, Jane Y. C.
AU - Roberts, Jenny R.
AU - Barger, Mark W.
AU - Butterworth, Leon
AU - Charron, Tina G.
AU - Castranova, Vince
T1 - Subschronic Silica Exposure Enhances Respiratory Defense Mechanisms and the Pulmonary Clearance of Listeria Monocytogenes in Rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/11//
VL - 12
IS - 11
M3 - Article
SP - 1017
EP - 1036
SN - 08958378
AB - Both Listeria monocytogenes infection and silica exposure have been shown to significantly alter immune responses. In this study, we evaluated the effect of preexposure to silica on lung defense mechanisms using a rat pulmonary L. monocytogenes infection model. Male Sprague-Dawley rats were instilled intratracheally with saline (vehicle control) or silica using either an acute treatment regimen (5 mg/kg; 3 days) or a subchronic treatment protocol (80 mg/kg; 35 days). At 3 or 35 days after silica instillation, the rats were inoculated intratracheally with either ~5000 or 500,000 L. monocytogenes. At 3, 5, and 7 days postinfection, the left lung was removed, homogenized, and cultured on brain heart infusion agar at 37°C. The numbers of viable L. monocytogenes were counted after an overnight incubation. Bronchoalveolar lavage (BAL) was performed on the right lungs, and BAL cell differentials, acellular lactate dehydrogenase (LDH) activity and albumin content were determined. Alveolar macrophage (AM) chemiluminescence (CL) and phagocytosis were assessed as a measure of macrophage function. Lung-associated lymph nodes were removed, and lymphocytes were recovered and differentiated. Preexposure to silica significantly increased the pulmonary clearance of L. monocytogenes as compared to saline controls. Exposure to silica caused significant increases in BAL neutrophils, LDH and albumin, and lymph-nodal T cells and natural killer (NK) cells in infected and noninfected rats. CL and phagocytosis were also elevated in silica-treated rats. In summary, the results demonstrated that exposure of rats to silica enhanced pulmonary immune responses, as evidenced by increases in neutrophils, NK cells, T lymphocytes, and macrophage activation. These elevations in pulmonary immune response are likely responsible for the increase in pulmonary clearance of L. monocytogenes observed with preexposure to silica. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silica
KW - Respiratory infections
N1 - Accession Number: 3859726; Antonini, James M. 1; Yang, Hui-Min 1; Ma, Jane Y. C. 1; Roberts, Jenny R. 1; Barger, Mark W. 1; Butterworth, Leon 1; Charron, Tina G. 1; Castranova, Vince 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Nov2000, Vol. 12 Issue 11, p1017; Subject Term: Silica; Subject Term: Respiratory infections; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 20p; Illustrations: 2 Black and White Photographs, 2 Charts, 10 Graphs; Document Type: Article
L3 - 10.1080/08958370050164635
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Marlene R.
AU - McNamara, Robert L.
AU - Segal, Jodi B.
AU - Kim, Nina
AU - Robinson, Karen A.
AU - Goodman, Steven N.
AU - Powe, Neil R.
AU - Bass, Eric B.
T1 - Efficacy of Agents for Pharmacologic Conversion of Atrial Fibrillation and Subsequent Maintenance of Sinus Rhythm.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/11//
VL - 49
IS - 11
M3 - Article
SP - 1033
EP - 1046
PB - Frontline Medical Communications
SN - 00943509
AB - CONTEXT Physicians have little evidentiary guidance for pharmacologic agent selection for atrial fibrillation (AF). OBJECTIVE To assess antiarrhythmic agent efficacy for AF conversion and subsequent maintenance of sinus rhythm (MSR). DATA SOURCE We searched the clinical trial database of the Cochrane Collaboration and MEDLINE encompassing literature from 1948 to May 1998. STUDY SELECTION We selected 36 (28%) articles eligible as randomized trials of nonpost-operative AF conversion or MSR in adults. DATA EXTRACTION Study quality; rates of conversion, MSR, and adverse events were extracted. DATA SYNTHESIS Compared with control treatment (placebo, verapamil, diltiazem, or digoxin), the odds ratio (OR) for conversion was greatest for ibutilide/dofetilide (OR=29.1; 95% confidence interval [CI], 9.8-86.1) and flecainide (OR=24.7; 95% CI, 9.0-68.3). Less strong but conclusive evidence existed for propafenone (OR=4.6; 95% CI, 2.6-8.2). Quinidine (OR=2.9; 95% CI, 1.2-7.0) had moderate evidence of efficacy for conversion. Disopyramide (OR=7.0; 95% CI, 0.3-153.0) and amiodarone (OR=5.7; 95% CI, 1.0-33.4) had suggestive evidence of efficacy. Sotalol (OR=0.4; 95% CI, 0.0-3.0) had suggestive evidence of negative efficacy. For MSR, strong evidence of efficacy existed for quinidine (OR=4.1; 95% CI, 2.545.7), disopyramide (OR=3.4; CI, 1.6-7.1), flecainide (OR=3.1; 95 % CI, 1.5-6.2), propafenone (OR=3.7; 95% CI, 2.4-5.7), and sotalol (OR=7.1; 95% CI, 3.8-13.4). The only amiodarone data, from comparison with disopyramide, provided moderate evidence of efficacy for MSR. No trial evaluated procainamide. Direct agent comparisons and adverse event data were limited. CONCLUSIONS Although multiple antiarrhythmic agents had strong evidence of efficacy compared with control treatment for MSR, ibutilide/dofetilide and flecainide had particularly strong evidence of efficacy compared with control treatment for AF conversion. There is sparse and inconclusive evidence on direct agent comparisons and adverse event rates. Obtaining information regarding these relative efficacies should be a research priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATRIAL fibrillation
KW - ATRIAL arrhythmias
KW - PROPAFENONE
KW - MYOCARDIAL depressants
KW - DISOPYRAMIDE
KW - QUINIDINE
KW - anti-arrhythmia agents
KW - Atrial fibrillation
KW - clinical trials
KW - meta-analysis
KW - randomized controlled trials
N1 - Accession Number: 3842268; Miller, Marlene R. 1,2,3; Email Address: mmiller@ahrq.gov; McNamara, Robert L. 4,5; Segal, Jodi B. 6; Kim, Nina 7; Robinson, Karen A. 7; Goodman, Steven N. 8; Powe, Neil R. 5,6; Bass, Eric B. 6; Source Information: Nov2000, Vol. 49 Issue 11, p1033; Subject: ATRIAL fibrillation; Subject: ATRIAL arrhythmias; Subject: PROPAFENONE; Subject: MYOCARDIAL depressants; Subject: DISOPYRAMIDE; Subject: QUINIDINE; Author-Supplied Keyword: anti-arrhythmia agents; Author-Supplied Keyword: Atrial fibrillation; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: meta-analysis; Author-Supplied Keyword: randomized controlled trials; Number of Pages: 14p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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ER -
TY - JOUR
AU - Zimmerman, M. L.
AU - Friedman, S. L.
T1 - Identification of Rodent Filth Exhibits.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2000/11//Nov/Dec2000
VL - 65
IS - 8
M3 - Article
SP - 1391
EP - 1394
SN - 00221147
AB - Three main types of rodent filth (rodent excreta pellets, gnawing, and nesting material) are described and identification procedures are listed. Suspect excreta pellets that may be encountered in foods from various animals are described in detail and presented in a dichotomous key for comparison and identification. The physical features associated with the excreta pellets (color, shape, size, weight, surface, and matrix composition) are listed for the insects and animals found in the key. Rodent gnawing and rodent nesting materials are defined and the importance of the paired incisor marks, scalloping along edges and the appearance of the building materials are described. The importance of urine, rodent excreta, hairs and/or parasites when defining nesting material, are discussed, along with the key elements used to recognize the gnawing direction by the rodents. Historical data on rodents and health/safety concerns when handling rodent filth exhibits are addressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Rodents
KW - Mammals
KW - Parasites
KW - Identification
KW - Exhibitions
KW - Urine
KW - excreta
KW - gnawing
KW - identification
KW - nesting material
KW - rodent
N1 - Accession Number: 28546318; Zimmerman, M. L. 1; Email Address: mzimmerm@ora.fda.gov; Friedman, S. L. 2; Affiliations: 1: U.S. Food & Drug Admin., 900 Madison Ave., Baltimore, MD 21201, U.S.A.; 2: U.S. Food & Drug Admin., Center for Veterinary Medicine; Issue Info: Nov/Dec2000, Vol. 65 Issue 8, p1391; Thesaurus Term: Rodents; Thesaurus Term: Mammals; Thesaurus Term: Parasites; Subject Term: Identification; Subject Term: Exhibitions; Subject Term: Urine; Author-Supplied Keyword: excreta; Author-Supplied Keyword: gnawing; Author-Supplied Keyword: identification; Author-Supplied Keyword: nesting material; Author-Supplied Keyword: rodent; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
ID - 107149695
T1 - Device safety. Handling adverse event reports...Center for Devices and Radiological Health (CDRH)
AU - Rich S
Y1 - 2000/11//
N1 - Accession Number: 107149695. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - United States Food and Drug Administration
KW - Equipment Safety
KW - Incident Reports
SP - 78
EP - 78
JO - Nursing
JF - Nursing
JA - NURSING
VL - 30
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant and Branch Chief, Center for Devices and Radiological Health, Food and Drug Administrtation, Rockville, Md
U2 - PMID: 11111664.
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TY - JOUR
AU - Toraason, Mark
AU - Sussman, Gordon
AU - Biagini, Raymond
AU - Meade, Jean
AU - Beezhold, Donald
AU - Germolec, Dori
T1 - Latex Allergy in the Workplace.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/11//
VL - 58
IS - 1
M3 - Article
SP - 5
EP - 14
PB - Oxford University Press / USA
SN - 10966080
AB - While less than 1% of the general population is sensitized to latex, the U.S. Occupational Safety and Health Administration estimates that 8–12% of health-care workers are sensitized. The major source of workplace exposure is powdered natural rubber latex (NRL) gloves. NRL is harvested from Hevea brasiliensis trees and ammoniated to prevent coagulation resulting in the hydrolysis of the latex proteins. Prior to use in manufacturing, the latex is formulated by the addition of multiple chemicals. Thus, human exposure is to a mixture of residual chemicals and hydrolyzed latex peptides. Clinical manifestations include irritant contact dermatitis, allergic contact dermatitis (type IV), and type I immediate hypersensitivity response. Type I (IgE-mediated) NRL allergy includes contact urticaria, systemic urticaria, angioedema, rhinitis, conjunctivitis, bronchospasm, and anaphylaxis. Taking an accurate history, including questions on atopic status, food allergy, and possible reactions to latex devices makes diagnosis of type-I latex allergy possible. To confirm a diagnosis, either in vivo skin prick testing (SPT) or in vitro assays for latex-specific IgE are performed. While the SPT is regarded as a primary confirmatory test for IgE-mediated disease, the absence of a U.S. Food and Drug Administration-licensed Hevea brasiliensis latex extract has restricted its use in diagnosis. Serological tests have, therefore, become critically important as alternative diagnostic tests. Three manufacturers currently have FDA clearance for in vitro tests, to detect NRL-specific IgE. The commercially available assays may disagree on the antibody status of an individual serum, which may be due to the assay`s detecting anti-NRL IgEs to different allergenic NRL proteins. Sensitized individuals produce specific IgE antibody to at least 10 potent Hevea allergens, Hev b 1–Hev b 10, each of which differs in its structure, size, and net charge. The relative content and ratios of Hevs in the final allergen preparation most probably could effect diagnostic accuracy. The Hev proteins have been cloned and expressed as recombinant proteins. Sequencing demonstrates both unique epitopes and sequences commonly found in other plant proteins. Sequence homology helps to explain the cross reactivity to a variety of foods experienced by latex allergic individuals. The development of recombinant allergens provides reagents that should improve the diagnostic accuracy of tests for latex allergy. Although clinical and exposure data have been gathered on the factors affecting response in latex-allergic individuals, less is known regarding the development of sensitization. Coupled with in vitro dermal penetration studies, murine models have been established to investigate the route of exposure in the development of latex sensitization. Time-course and dose-response studies have shown subcutaneous, intratracheal, or topical administrations of non-ammoniated latex proteins to induce IgE production. Both in vitro penetration and in vivo studies highlight the importance of skin condition in the development of latex allergy, with enhanced penetration and earlier onset of IgE production seen with experimentally abraded skin. The diagnosis of latex allergy is complicated by these variables, which in turn hinder the development of intervention strategies. Further epidemiological assessment is needed to more explicitly define the scope, trends, and demographics of latex allergy. Diagnostic accuracy can be improved through greater knowledge of proteins involved in the development of latex allergy, and better documentation of the presently available diagnostic tests. In vivo and in vitro models can elucidate mechanisms of sensitization and provide an understanding of the role of the exposure route in latex allergy-associated diseases. Together, these efforts can lead to intervention strategies for reducing latex allergy in the workplace. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Latex allergy
KW - Work environment
KW - Rubber
KW - Contact dermatitis
KW - United States
KW - contact dermatitis
KW - hypersensitivity
KW - latex allergy
KW - natural rubber latex (NRL)
KW - United States. Food & Drug Administration
N1 - Accession Number: 44611738; Toraason, Mark 1; Email Address: mtorasson@cdc.gov; Sussman, Gordon 2; Biagini, Raymond 1; Meade, Jean 3; Beezhold, Donald 4; Germolec, Dori 5; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226; 2: University of Toronto, Ontario, Canada M4V1R2; 3: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 4: Guthrie Research Institute, Sayre, Pennsylvania 18840; 5: National Institute for Environmental Health Science, Research Triangle Park, North Carolina 27709; Issue Info: Nov2000, Vol. 58 Issue 1, p5; Subject Term: Latex allergy; Subject Term: Work environment; Subject Term: Rubber; Subject Term: Contact dermatitis; Subject: United States; Author-Supplied Keyword: contact dermatitis; Author-Supplied Keyword: hypersensitivity; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: natural rubber latex (NRL) ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; Number of Pages: 10p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
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ER -
TY - JOUR
AU - Zhong, B. Z.
AU - Siegel, P. D.
T1 - Induction of Micronuclei following Exposure to Methylene Di-phenyl Diisocyanate: Potential Genotoxic Metabolites.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/11//
VL - 58
IS - 1
M3 - Article
SP - 102
EP - 108
PB - Oxford University Press / USA
SN - 10966080
AB - Methylene di-phenyl diisocyanate (MDI) is used to make polyurethane products. The predominant occupational disease attributed to diisocyanates, including MDI, is asthma; however, the potential for genotoxicity has also been of concern. Diisocyanates are very reactive compounds that can undergo nonenzymatic hydrolysis to form methylenedianiline (MDA), or react under physiological conditions with primary amines to form ureas and/or with thiols to form labile thiol acid esters. MDA is a carcinogen in animals and a suspected carcinogen in humans. Brown Norway rats (BNR) were exposed to either 7 or 113 mg/m3 MDI aerosol for 1 h/week ×3 weeks and sacrificed 1 week later. Micronuclei (MN) formation was assessed from bone marrow polychromatic erythrocytes (PCE). A dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MN-PCEs) was noted. In vitro exposure of Chinese hamster lung fibroblasts (V79) to MDA or MDI-thiol conjugates, but not to MDI, significantly increased the frequency of MN. MDI-thiol conjugate-exposed cell cultures did not have detectable levels of MDA. A significant increase in the number of V79 cells in metaphase, as well as the number of cells with precipitants within both the cytoplasm and nuclei, were noted in MDI-glutathione-exposed cultures. The results of this study indicate that MDI aerosol exposure can cause MN formation through either the hydrolysis of MDI to MDA or possibly the formation of thiol conjugates. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Metabolites
KW - Carbenes (Methylene compounds)
KW - Nucleolus
KW - Mice as laboratory animals
KW - Cells
KW - Brown Norway rats
KW - metabolites
KW - methylene di-phenyl diisocyanate
KW - micronucleus
KW - V79 cells
N1 - Accession Number: 44611755; Zhong, B. Z. 1; Siegel, P. D. 1; Email Address: pds3@cdc.gov; Affiliations: 1: Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888; Issue Info: Nov2000, Vol. 58 Issue 1, p102; Thesaurus Term: Toxicology; Thesaurus Term: Metabolites; Thesaurus Term: Carbenes (Methylene compounds); Subject Term: Nucleolus; Subject Term: Mice as laboratory animals; Subject Term: Cells; Author-Supplied Keyword: Brown Norway rats; Author-Supplied Keyword: metabolites; Author-Supplied Keyword: methylene di-phenyl diisocyanate; Author-Supplied Keyword: micronucleus; Author-Supplied Keyword: V79 cells; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - McNamara, Peggy
AU - Caldwell, Blake
AU - Fraser, Irene
AU - De La Mare, Jan
AU - Arent, Jill
T1 - Quality Improvement: New Contributions from the Field of Health Services Research.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 5
EP - 8
SN - 10775587
N1 - Accession Number: 54898118; McNamara, Peggy 1; Caldwell, Blake 2; Fraser, Irene 1; De La Mare, Jan 1; Arent, Jill 3; Source Information: Supplement 2, Vol. 57 Issue S2, p5; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 1443
L3 - 10.1177/107755870005700201
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ER -
TY - JOUR
AU - Scanlon, Dennis P.
AU - Rolph, Elizabeth
AU - Darby, Charles
AU - Doty, Hilary E.
T1 - Are Managed Care Plans Organizing for Quality?
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 9
EP - 32
SN - 10775587
AB - This article examines the degree to which managed care organizations (MCOs) are reorganizing to take responsibility for the quality of care and service they provide. Specifically, factors prompting plans to focus on quality improvement (QI) and how they may be building the capacity to improve quality are considered. The authors’ analysis is based on executive interviews with the plan medical directors, QI directors, and chief executive officers (CEOs) in a sample of 24 health plans. The overall response rate was 58.3 percent (medical director = 62.5 percent, QI director = 79.2 percent, CEO = 33.3 percent). The authors queried respondents about (1) perceived drivers and obstacles to the development of an effective QI program, (2) plan organizational structure for QI, and (3) technical capacities for data collection, management, and performance measurement. The results suggest that MCOs are responding to outside pressures to engage in QI. They are reorganizing their management structures and more slowly and tentatively are building technical capacity for QI. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898119; Scanlon, Dennis P. 1; Rolph, Elizabeth 2; Darby, Charles 3; Doty, Hilary E. 1; Source Information: Supplement 2, Vol. 57 Issue S2, p9; Number of Pages: 24p; Document Type: Article; Full Text Word Count: 9032
L3 - 10.1177/107755870005700202
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DB - hch
ER -
TY - JOUR
AU - Fraser, Irene
AU - McNamara, Peggy
T1 - Employers: Quality Takers or Quality Makers?
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 33
EP - 52
SN - 10775587
AB - This article provides a synthesis of past research to help understand the extent to which employers are using their considerable market power to drive health care quality. Are employers quality takers or quality makers? The literature provides some clues about aspects of quality employers are attempting to influence, strategies they are pursuing to influence quality, and their impact. Some employers are interested in some indicators of quality and are incorporating them in a variety of different purchasing strategies. The indicators most frequently used by employers, however, probably are not the ones that clinical experts and policy makers would select as most reflective of clinical quality. It appears that employers as a group are becoming more informed quality takers but are not yet quality makers—with the exception of a few well-resourced outliers. Recent events provide mixed signals about whether the future employer role in influencing quality will diminish, stall, or flourish. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898120; Fraser, Irene 1; McNamara, Peggy 1; Source Information: Supplement 2, Vol. 57 Issue S2, p33; Number of Pages: 20p; Document Type: Article; Full Text Word Count: 8372
L3 - 10.1177/107755870005700203
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ER -
TY - JOUR
AU - Brach, Cindy
AU - Sanches, Linda
AU - Young, Donald
AU - Rodgers, James
AU - Harvey, Holly
AU - McLemore, Thomas
AU - Fraser, Irene
T1 - Wrestling with Typology: Penetrating the “Black Box” of Managed Care by Focusing on Health Care System Characteristics.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 93
EP - 115
SN - 10775587
AB - The health care system has undergone a fundamental transformation undermining the usefulness of the typology of the health maintenance organization, the independent practice association, the preferred provider organization, and so forth. The authors present a new approach to studying the health care system. In matrix form, they have identified a set of organizational and delivery characteristics with the potential to influence outcomes of interest, such as access to services, quality, health status and functioning, and cost. The matrix groups the characteristics by domain—financial features, structure, care delivery and management policies, and products—and by key roles in the health care system—sponsor, plan, provider intermediary organization, and direct services provider. The matrix is a tool for researchers, administrators, clinicians, data collectors, regulators, and other policy makers. It suggests a new set of players to be studied, emphasizes the relationships among the players, and provides a checklist of independent, control, and interactive variables to be included in analyses. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898123; Brach, Cindy 1; Sanches, Linda 2; Young, Donald 3; Rodgers, James 4; Harvey, Holly 2; McLemore, Thomas 5; Fraser, Irene 1; Source Information: Supplement 2, Vol. 57 Issue S2, p93; Number of Pages: 23p; Document Type: Article; Full Text Word Count: 7966
L3 - 10.1177/107755870005700206
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ER -
TY - JOUR
ID - 106999955
T1 - Healthy People 2010.
AU - Kyler P
AU - Merryman MB
Y1 - 2000/11/06/2000 Nov 6
N1 - Accession Number: 106999955. Language: English. Entry Date: 20010223. Revision Date: 20150820. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Allied Health; USA. NLM UID: 9602488.
KW - Healthy People 2010
KW - Education, Continuing (Credit)
KW - Health Promotion
KW - International Classification of Functioning, Disability, and Health
KW - Occupational Therapy
KW - Adjustment Disorders
KW - Clinical Assessment Tools
SP - CE1
EP - 6
JO - OT Practice
JF - OT Practice
JA - OT PRACT
VL - 5
IS - 22
CY - Bethesda, Maryland
PB - American Occupational Therapy Association
SN - 1084-4902
AD - Public Health Analyst, Genetic Services Branch, Maternal and Child Health Bureau, Washington, DC
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DB - rzh
ER -
TY - JOUR
AU - G. J. Huba
AU - Lisa A. Meichior
AU - A. T. Panter
AU - Lee Trevithick
AU - Elizabeth R. Woods
AU - Eric Wright
AU - Rudy Feudo
AU - Steven Tierney
AU - Arlene Schneir
AU - Adam Tenner
AU - Gary Remafedi
AU - Brian Greenberg
AU - Marsha Sturdevant
AU - Elizabeth Goodman
AU - Antigone Hodgins
AU - Michael Wallace
AU - Russell E. Brady
AU - Barney Singer
T1 - RISK FACTORS AND CHARACTERISTICS OF YOUTH LWING WITH, OR AT HIGH RISK FOR, HIV.
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
Y1 - 2000/12//
VL - 12
IS - 6
M3 - Article
SP - 557
EP - 575
SN - 08999546
AB - The article focuses on a study that examined various risky sex and drug-use behaviors associated with increased opportunity of HIV exposure, including sex with males. Three interrelated areas of HIV risk behavior and characteristics of youth have been consistently identified as key vulnerabilities and predictors of HIV serostatus: risky sexual behavior, substance abuse, and personal resources. Analyses were based on 8,196 clients who were part of the national evaluation database and who had complete data for all model predictors. The investigation revealed that a basic set of intake information obtained during brief encounters with high-risk adolescents and young adults may provide very valuable leads about that person's HIV status and risk. This information can assist with efficient and accurate triage to needed medical and psychosocial services and may help guide decisions by health care providers about appropriate intervention and programming for the client. The sample considered in this study, 8,196 youth, was unique in that it describes a nonrandom group of very high-risk individuals who have received an outreach contact through the different mechanisms that predisposed them to that type of contact.
KW - HIV infections
KW - Young adults -- Sexual behavior
KW - Drug abuse
KW - Medical care
KW - Sex customs
KW - Substance abuse
N1 - Accession Number: 18671178; G. J. Huba 1; Lisa A. Meichior 1; A. T. Panter 2,3; Lee Trevithick 4; Elizabeth R. Woods 5; Eric Wright 6; Rudy Feudo 7; Steven Tierney 8; Arlene Schneir 9; Adam Tenner 4; Gary Remafedi 10; Brian Greenberg 11; Marsha Sturdevant 12; Elizabeth Goodman 5; Antigone Hodgins 13; Michael Wallace 14; Russell E. Brady 15; Barney Singer 15; Affiliations: 1: Measurement Group, Culver City, CA.; 2: University of North Carolina Chapel Hill.; 3: Senior Consultant, Measurement Group.; 4: YouthCare, Seattle, WA.; 5: Children's Hospital, Boston.; 6: Indiana University—Purdue University, Indianapolis.; 7: Greater Bridgeport Adolescent Pregnancy Project, Bridgeport, CT.; 8: Health Initiatives for Youth, San Francisco.; 9: Children's Hospital, Los Angeles.; 10: University of Minnesota Youth and AIDS Projects, Minneapolis.; 11: Walden House, San Francisco.; 12: University of Alabama, Birmingham.; 13: Bay Area Young Positives, San Francisco.; 14: Indiana State Department of Health, Indianapolis.; 15: Health Resources and Services Administration, Rockville, MD.; Issue Info: Dec2000, Vol. 12 Issue 6, p557; Subject Term: HIV infections; Subject Term: Young adults -- Sexual behavior; Subject Term: Drug abuse; Subject Term: Medical care; Subject Term: Sex customs; Subject Term: Substance abuse; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107050408
T1 - FDA perspective. Online information for health care professionals.
AU - Rados WM
Y1 - 2000/12//12/1/2000
N1 - Accession Number: 107050408. Language: English. Entry Date: 20010907. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Health Information
KW - Information Resources
KW - World Wide Web
SP - 2528
EP - 2530
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 62
IS - 11
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Food and Drug Administration, Rockville, MD
U2 - PMID: 11130236.
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UR - Related websites: http://www.fda.gov/cder/drug/default.htm; http://www.fda.gov/oc/oha/default.htm; http://www.fda.gov/cder/cancer/tour.htm; http://vm/cfsan.fda.gov/~dms/cos-toc.html; http://www.fda.gov/cder/pediatric/index/htm; http://www.fda.gov/cber/products.htm; http://www.fda.gov/cdrh/index/html; http://vm.cfsan.fda.gov/list.html~dms/cost-toc.html
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107006844
T1 - Status of infection surveillance and control programs in the United States, 1992-1996.
AU - Nguyêñ GT
AU - Proctor SE
AU - Sinkowitz-Cochran RL
AU - Garrett DO
AU - Jarvis WR
Y1 - 2000/12//2000 Dec
N1 - Accession Number: 107006844. Corporate Author: Association for Professionals in Infection Control and Epidemiology, Inc.. Language: English. Entry Date: 20010316. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Disease Surveillance -- Trends -- United States
KW - Infection Control -- Utilization -- United States
KW - Survey Research
KW - Surveys
KW - Questionnaires
KW - Convenience Sample
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Cross Infection -- Prevention and Control
KW - Infection Preventionists
KW - United States
KW - Health Facility Administration
KW - Epidemiology
KW - Human
SP - 392
EP - 400
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 28
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: Nosocomial infections have been recognized as a source of morbidity and mortality throughout the world for several decades. In the United States, an estimated 2.1 million nosocomial infections occur annually in acute care hospitals alone. Infection surveillance and control programs (ISCPs) play a vital role in addressing this problem, but no national studies have described the status and composition of these programs since the 1970s. METHODS: In January 1997, a voluntary survey was sent by mail to members of the Association for Professionals in Infection Control and Epidemiology, Inc. Only one response per facility was requested. The survey asked for information for the years 1992 to 1996 (study period), and questions pertained to characteristics of the health care facility in which the respondent worked, characteristics of the ISCP and its personnel, and the overall level of administration support for infection control activities. RESULTS: Completed questionnaires were received from personnel at 187 health care facilities located in 40 states and the District of Columbia. The majority (76.5%) of responding facilities were nongovernment owned, and 57.2% were classified as general acute care facilities. The number of licensed beds at these facilities remained stable throughout the study period, but all other measures of facility size and activity (eg, number of patient days and number of nurses) decreased by as much as 28.9%. In 1992, ISCPs were most likely to be organizationally located in the Nursing Department, but by 1996, many had been transferred to departments of Medical Records, Quality Assurance, or Risk Management. Throughout the course of the study period, the number of facilities performing surveillance for health care-associated infections in outpatient settings increased by 44.0%, from 100 to 144. In 1996, only 47.6% of facilities had a hospital epidemiologist (HE), and HEs devoted a median of 15% or less of their time to infection control activities. For the most part, HEs were trained in infectious diseases, and few had certification in infection control. Infection control professionals (ICPs) were much more common than were HEs (ICPs were reported at 97.9% of respondents' facilities in 1996), and they spent the majority (80% in 1996) of their time on infection control activities. During the course of the study period, increasing numbers of facilities had ICPs who had certification in infection control. Furthermore, most respondents did not report a change over time in the level of administration support for infection control activities. CONCLUSIONS: Health care delivery has changed dramatically during the past 20 years. This study presents an updated description of ISCPs in the United States. Our results illustrate several changing parameters, such as departmental shifts and increased outpatient surveillance, that reflect adjustments in health care priorities during the study period. As the transformation of the health care system continues, continued evaluation of the status of ISCPs on a national level will be necessary. Diligent monitoring, proactive measures, and collaboration between infection control organizations and government agencies will be vital for the prevention and control of health care-associated infections in the future.
SN - 0196-6553
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, Atlanta
U2 - PMID: 11114608.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - METHNER, M. M.
AU - BOWMAN, J. D.
T1 - Hazard Surveillance for Industrial Magnetic Fields: I. Walkthrough Survey of Ambient Fields and Sources.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2000/12//
VL - 44
IS - 8
M3 - Article
SP - 603
EP - 614
SN - 00034878
AB - A walkthrough survey method was developed for measuring ambient magnetic fields (MFs) in industrial facilities as the first stage in hazard surveillance. This survey was designed to measure the mean and peak MF magnitudes at extremely low frequencies (ELFs), so that factories could be ranked by MF levels and prioritized for subsequent personal exposure monitoring. Sixty-two facilities from 13 Standard Industrial Classifications (SICs) with the highest monthly electric power usage were surveyed. To measure ambient MFs, a structured walkthrough survey with a special emphasis on workstations was conducted with an EMDEX-II meter in continuous operation, while MF sources were noted. The broadband MF data (40-800 Hz) for each facility were summarized with the geometric mean (GM) and the average of the five highest readings (Hi-5). The range of the GM magnetic field magnitude was 0.04-1.61 μT, where the maximum was measured at a steel mill operating large electric furnaces. Maximum values for specific sources were highly variable across and within facilities (Hi-5 range: 1.0-530 μT). Chemical and Allied Products (SIC 28) and Primary Metal Products (SIC 33) had facilities with GM and Hi-5 magnetic fields greater than any of the other industrial categories. However, the SIC categories were found to be poor predictors of the ambient MF in this sample of factories. A weak relationship was found between the facility-specific monthly electric power consumption and the GM magnetic field magnitude, but confidence limits were too broad to make meaningful exposure predictions from electric power data. Overall, 89% of the GMs were at or below 0.4 μT, consistent with most other studies that collected industrial MF exposure data. The walkthrough survey is a practical way of measuring ambient MFs in a large number of workplaces, and should be evaluated with personal measurements as a screening method for hazard surveillance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnetic fields
KW - CLASSIFICATION
KW - Electric power consumption
KW - Occupational diseases
KW - Industries
KW - Surveys
KW - Steel mills
KW - Electric furnaces
KW - Data
KW - Work environment
KW - ELF
KW - EMDEX
KW - EMF
KW - extremely low frequency
N1 - Accession Number: 45226802; METHNER, M. M. 1; Email Address: mmm5@cdc.gov; BOWMAN, J. D. 1; Affiliations: 1: National Institute for Occupational Safety and Health (Mail Stop R-19), 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; Issue Info: Dec2000, Vol. 44 Issue 8, p603; Thesaurus Term: Magnetic fields; Thesaurus Term: CLASSIFICATION; Thesaurus Term: Electric power consumption; Thesaurus Term: Occupational diseases; Subject Term: Industries; Subject Term: Surveys; Subject Term: Steel mills; Subject Term: Electric furnaces; Subject Term: Data; Subject Term: Work environment; Author-Supplied Keyword: ELF; Author-Supplied Keyword: EMDEX; Author-Supplied Keyword: EMF; Author-Supplied Keyword: extremely low frequency; NAICS/Industry Codes: 333416 Heating equipment and commercial refrigeration equipment manufacturing; NAICS/Industry Codes: 416120 Plumbing, heating and air-conditioning equipment and supplies merchant wholesalers; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 236210 Industrial Building Construction; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BOWMAN, J. D.
AU - METHNER, M. M.
T1 - Hazard Surveillance for Industrial Magnetic Fields: II. Field Characteristics from Waveform Measurements.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2000/12//
VL - 44
IS - 8
M3 - Article
SP - 615
EP - 633
SN - 00034878
AB - Magnetic field characteristics have been surveyed systematically in six factories with the Multiwave® II waveform capture instrument. These six facilities manufactured plastics, pharmaceuticals, cement, liquid air products, aluminum parts, and aluminum-framed filters. The study goals were to survey the physical characteristics of magnetic fields that may be related to biological effects under various interaction mechanisms and to relate those characteristics to the field's sources. From 59 waveform measurements at worker locations near sources, we calculated the extremely low frequency (ELF) and static field magnitudes, their frequency characteristics, and spatial characteristics of the 60 Hz component. The RMS vector magnitude of the ELF magnetic field (the usual exposure metric in most studies) had medians ranging from 0.53 to 12.83 μT in the six factories. The static magnetic field magnitudes had medians of 24.2-46.2 μT, which is well below the geomagnetic reference field of 55.0 μT because of shielding from steel structures. The maximum static field was 128.6 μT near a DC motor. The frequency spectra of the most common fields is dominated by 60 Hz, and has a median total harmonic distortion equal to 14.8%. The most common higher frequencies are the third, fifth, and second harmonics of 60 Hz. However, magnetic fields in these workplaces had many other 60 Hz harmonics and non-harmonic frequencies due particularly to electric motors and computer monitors. The 60 Hz component magnetic fields have elliptical polarization with median axial ratio of 25.4%. The average proportion of the 60 Hz component parallel to the static field vector was 51.5±3.0%, which indicates a significant trend towards perpendicular orientation between these two field components. In this survey of only six factories, the Multiwave® II measurements documented a wide diversity of complex magnetic field characteristics and non-sinusoidal waveforms. Although these characteristics are important to the various mechanisms postulated to explain biological effects, they are overlooked by the popular exposure assessment methods which only measure the ELF magnitude. Therefore, spot measurements with the Multiwave® II or similar waveform capture instruments are necessary for a complete magnetic field exposure assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnetic fields
KW - Factories
KW - Geomagnetism
KW - Spectrum analysis
KW - Industrial surveys
KW - Cathode ray oscillographs
KW - Harmonics (Electric waves)
KW - Polarization (Electricity)
KW - Electric motors
KW - cancer
KW - ELF
KW - EMF
KW - exposure assessment
KW - extremely low frequency
KW - neurodegenerative diseases
KW - waveform
N1 - Accession Number: 45226803; BOWMAN, J. D. 1; Email Address: jdb0@cdc.gov; METHNER, M. M. 1; Affiliations: 1: National Institute for Occupational Safety and Health (Mail Stop C-27), 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; Issue Info: Dec2000, Vol. 44 Issue 8, p615; Thesaurus Term: Magnetic fields; Thesaurus Term: Factories; Thesaurus Term: Geomagnetism; Thesaurus Term: Spectrum analysis; Subject Term: Industrial surveys; Subject Term: Cathode ray oscillographs; Subject Term: Harmonics (Electric waves); Subject Term: Polarization (Electricity); Subject Term: Electric motors; Author-Supplied Keyword: cancer; Author-Supplied Keyword: ELF; Author-Supplied Keyword: EMF; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: extremely low frequency; Author-Supplied Keyword: neurodegenerative diseases; Author-Supplied Keyword: waveform; NAICS/Industry Codes: 335312 Motor and Generator Manufacturing; Number of Pages: 19p; Document Type: Article
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ER -
TY - JOUR
AU - Boundy, Maryanne
AU - Leith, David
AU - Hands, David
AU - Gressel, Michael
AU - Burroughs, G. Edward
T1 - Performance of Industrial Mist Collectors Over Time.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/12//
VL - 15
IS - 12
M3 - Article
SP - 928
EP - 935
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Effective, economical control of metalworking fluid mists at the source is important, because exposure to these mists may cause adverse health effects. This study investigated performance changes over time for industrial collectors that removed metalworking fluid mist in the laboratory and in a transmission plant. Aerosizers were used to measure the efficiency of each stage in several multistage collectors as a function of mist droplet diameter, for up to one year of continuous operation. Metal-mesh, first-stage filters operated at low pressure drops and were effective at removing droplets larger than 3 to 5 Θ m in diameter. Some second-stage filters worked better than others. Both ''65 percent'' and ''95 percent'' cartridge filters failed after only a few weeks; their efficiencies decreased substantially over that time. Pocket filters and cylindrical cartridges used as second-stage filters also decreased in efficiency for submicron droplets. Whereas filters for solid particles load continuously to form a dust cake that increases efficiency, mist filters form no cake and load only to the point where collection equals drainage. As a mist filter loads, the interstitial gas velocity increases, so that efficiency decreases for small droplets that collect by diffusion. Although a third-stage 95 percent DOP filter showed important decreases in efficiency over time for submicron droplets, third-stage HEPA filters operated with efficiencies that consistently approached 100 percent for droplets of all sizes, even after one year of operation. These results suggest that the performance of second-stage filters can be improved if they can be made to drain collected liquid more effectively. For high efficiency, mist collectors should use a HEPA filter as a final stage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metalworking industries
KW - Oil mist lubrication
KW - Metalworking fluids
KW - MIST COLLECTORS
KW - Oil mist
N1 - Accession Number: 4176653; Boundy, Maryanne 1; Leith, David 1; Hands, David 2; Gressel, Michael 3; Burroughs, G. Edward 3; Affiliations: 1: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina; 2: Occupational and Environmental Health Sciences, Ford Motor Company, Dearborn, Michigan; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Dec2000, Vol. 15 Issue 12, p928; Subject Term: Metalworking industries; Subject Term: Oil mist lubrication; Author-Supplied Keyword: Metalworking fluids; Author-Supplied Keyword: MIST COLLECTORS; Author-Supplied Keyword: Oil mist; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/104732200750051166
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lorberau, Charles D.
AU - Pride, J Eannelle L.
T1 - A Laboratory Comparison of Two Media for Use in the Assessment of Dermal Exposure to Pesticides.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/12//
VL - 15
IS - 12
M3 - Article
SP - 946
EP - 950
PB - Taylor & Francis Ltd
SN - 1047322X
AB - In a laboratory study, gauze pads and Empore1 filters were compared for their ability to assess the dermal exposure of two insecticides (chlorpyrifos and diazinon) and five herbicides (atrazine, alachlor, metolachlor, cyanazine, and 2,4-D ethylhexyl ester). The analytes, when analyzed by gas chromatography with flame ionization detection, were found to have a linear dynamic range to at least 250 Θ g/mL. While a number of different solvents were examined for the desorption of the analytes, methanol was found to be the best solvent for the recovery of all the analytes from 16-ply gauze pads, while 20 percent ethyl acetate in hexane was the preferred solvent for the styrene divinylbenzeneimpregnated Empore filters. Limits of detection (LODs) for the analytes were comparable for both media. For Empore filters, the LODs were 50 Θ g/sample for atrazine, alachlor, chlorpyrifos, diazinon, and 2,4-D ethylhexy ester, with 30 Θ g/ sample for metolachlor, and 80 Θ g/sample for cyanazine. For gauze pads, the LODs were 40 Θ g/sample for metolachlor, 50 Θ g/sample for alachlor, diazinon, and 2,4-D ethylhexy ester, 60 Θ g/sample for atrazine and chlorpyrifos, and 80 Θ g/sample for cyanazine. Both gauze pads and Empore filters gave quantitative recovery for all analytes except chlorpyrifos and 2,4-D ethylhexyl ester under ambient conditions (18[sup o]C, 70% relative humidity) for up to 30 days; these analytes required refrigeration for that period to reach over 90 percent recovery. To assess the effect of environmental conditions on the recovery of the analytes, samples of each media were spiked at about 125 Θ g per analyte/sample (except cyanazine which was spiked at 190 Θ g) and challenged for 8 hr under high (80%) and low (20%) humidity and high (40[sup o]C) and low (5[sup o]C) temperature conditions in an environmental chamber. While the Empore samples gave quantitative recovery after being challenged, recovery from the gauze pads was affected by environmental conditions, especially high temperature. Recovery from gauze pads was below 30 percent for some analytes under high temperature/high humidity conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlorpyrifos
KW - Diazinon
KW - DERMAL SAMPLING
KW - EMPORE
KW - PESTICIDES
N1 - Accession Number: 4176651; Lorberau, Charles D. 1; Pride, J Eannelle L. 2; Affiliations: 1: Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Project IMHOTEP, Stillman College, Tuscaloosa, Alabama; Issue Info: Dec2000, Vol. 15 Issue 12, p946; Thesaurus Term: Chlorpyrifos; Thesaurus Term: Diazinon; Author-Supplied Keyword: DERMAL SAMPLING; Author-Supplied Keyword: EMPORE; Author-Supplied Keyword: PESTICIDES; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/104732200750051184
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107022543
T1 - Parents as partners in the medical home: part 4: a family-professional partnership.....medical home assures continuity of care
AU - McPherson M
AU - Weissman G
AU - Strickland B
Y1 - 2000/12//
N1 - Accession Number: 107022543. Language: English. Entry Date: 20010511. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 7702637.
KW - Pediatric Care
KW - Special Populations -- In Infancy and Childhood
KW - Continuity of Patient Care -- In Infancy and Childhood
KW - Primary Health Care -- In Infancy and Childhood
KW - Developmental Disabilities
KW - Child, Disabled
KW - Child Behavior Disorders
KW - Professional-Family Relations
KW - Affective Disorders -- In Infancy and Childhood
KW - Physician's Role
KW - Information Resources
KW - World Wide Web
KW - Parents of Disabled Children
KW - Child
SP - 102
EP - 105
JO - Exceptional Parent
JF - Exceptional Parent
JA - EXCEPTIONAL PARENT
VL - 30
IS - 12
CY - Johnstown, Pennsylvania
PB - EP World, Inc.
SN - 0046-9157
AD - Director, Division of Services for Children with Special Healthcare Needs, Maternal and Child Health Bureau (MCHB), Health Resources and Services Administration, US Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107069888
T1 - Steering a steady course in an era of compulsory treatment: taking mental health nursing into the millennium.
AU - Howell V
AU - Norman I
Y1 - 2000/12//
N1 - Accession Number: 107069888. Language: English. Entry Date: 20011123. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9212352.
KW - Psychiatric Nursing -- Trends
KW - Mental Health Services
KW - Health Policy
KW - Nursing Role
KW - Nursing Practice
KW - National Health Programs
KW - Public Opinion
KW - Safety
KW - Control (Psychology)
KW - Community Mental Health Services
KW - Mental Health Personnel -- Psychosocial Factors
KW - Nurse Attitudes
KW - Psychiatric Nursing -- Ethical Issues
KW - Stress, Occupational
KW - Nurse-Patient Relations
KW - Political Participation
SP - 605
EP - 616
JO - Journal of Mental Health
JF - Journal of Mental Health
JA - J MENT HEALTH
VL - 9
IS - 6
CY - Oxfordshire,
PB - Routledge
AB - Serious concern about public safety underpins development of mental health services that will inevitably lead to a more explicit policing role for mental health nurses in particular. Many mental health nurses are understandably concerned about this trend, however, we argue that their pessimism is unfounded. For the first time in a generation the current national strategy for mental health services is accompanied by an investment programme which, whatever its deficits, marks an attempt to ensure that previous deficits are made good. Further, evidence from other countries where compulsory treatment has been introduced would suggest that the success or failure of such measures is related to whether or not they are integrated into effective, comprehensive and adequately funded systems of mental health care. This paper discusses steps that mental health nurses might take to ensure that they maintain a role whose primary purpose continues to be the care of the individual patient (service user) even within a health care system oriented increasingly towards social control.
SN - 0963-8237
AD - Center for Mental Health Services Development in Wales, The Business School, University of Glamorgan, Treforest, Pontypridd, CF37 1DL, UK. E-mail: hjonesst@glam.ac.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Selden, Thomas M.
AU - Moeller, John F.
T1 - Estimates of the Tax Subsidy for Employment-Related Health Insurance.
JO - National Tax Journal
JF - National Tax Journal
Y1 - 2000/12//Dec2000 Part 1
VL - 53
IS - 4
M3 - Article
SP - 877
EP - 887
PB - National Tax Association
SN - 00280283
AB - This paper uses the MEDSIM health care microsimulation model developed by researchers at the Agency for Healthcare Research and Quality to compute the magnitude and distribution of the tax subsidy for employment-related health insurance premiums. We also present estimates of the revenue gain that would be associated with a variety of caps on the amount of contributions that can be excluded from the tax base. [ABSTRACT FROM AUTHOR]
AB - Copyright of National Tax Journal is the property of National Tax Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAYROLL tax
KW - CORPORATE taxes
KW - TAXATION
KW - HEALTH insurance premiums
KW - STATISTICAL matching
N1 - Accession Number: 3974454; Selden, Thomas M. 1; Moeller, John F. 1; Affiliations: 1: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD 20852; Issue Info: Dec2000 Part 1, Vol. 53 Issue 4, p877; Thesaurus Term: PAYROLL tax; Thesaurus Term: CORPORATE taxes; Thesaurus Term: TAXATION; Subject Term: HEALTH insurance premiums; Subject Term: STATISTICAL matching; NAICS/Industry Codes: 921130 Public Finance Activities; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 5385
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 107012210
T1 - Occupatinal skin diseases.
AU - Lushniak BD
Y1 - 2000/12//2000 Dec
N1 - Accession Number: 107012210. Language: English. Entry Date: 20010406. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - Occupational Diseases
KW - Skin Diseases
KW - Skin Diseases -- Etiology
KW - Dermatitis, Contact -- Diagnosis
KW - Dermatitis, Contact -- Etiology
KW - Dermatitis, Contact -- Therapy
KW - Skin Diseases, Infectious
KW - Urticaria -- Etiology
KW - Urticaria -- Therapy
KW - Urticaria -- Diagnosis
KW - Skin Diseases -- Diagnosis
KW - Skin Diseases -- Therapy
KW - Skin Neoplasms
SP - 895
EP - 915
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 27
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Primary care physicians will likely see a wide variety of occupational skin diseases in their practices, including allergic contact dermatitis, irritant contact dermatitis, contact urticaria, a variety of infectious diseases, and skin cancers. The ideal role of a medical practitioner involved in occupational dermatology is not only to diagnose and treat patients, but also to determine the cause of the occupational skin disease and to make recommendations for its prevention. Making the diagnosis and offering treatment, determining the cause, and recommending measures can be difficult undertakings. Copyright © 2000 by W.B. Saunders Company
SN - 0095-4543
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, US Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-12, Cincinnati, OH 45226
U2 - PMID: 11072293.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107012210&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107099076
T1 - Preventing fraud and abuse...Healthcare Integrity and Protection Data Bank (HIPDB)
AU - Chen V
Y1 - 2000/12//2000 Dec-Jan
N1 - Accession Number: 107099076. Language: English. Entry Date: 20000401. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Allied Health; USA. NLM UID: 9216135.
KW - Fraud -- Prevention and Control
KW - Health Services Misuse
KW - Resource Databases, Health
KW - Information Resources
SP - 34
EP - 34
JO - Rehab Management: The Interdisciplinary Journal of Rehabilitation
JF - Rehab Management: The Interdisciplinary Journal of Rehabilitation
JA - REHAB MANAGE
VL - 13
IS - 1
CY - Overland Park, Kansas
PB - Allied Media LLC
SN - 0899-6237
AD - Health Services Chief Professional Officer, Health Resources and Services Administration
U2 - PMID: 10847993.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107099076&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Slikker Jr., William
AU - Beck, Barbara D.
AU - Cory-Slechta, Deborah A.
AU - Paule, Merle G.
AU - Anger, W. Kent
AU - Bellinger, David
T1 - Cognitive Tests: Interpretation for Neurotoxicity? (Workshop Summary).
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2000/12//
VL - 58
IS - 2
M3 - Article
SP - 222
EP - 234
PB - Oxford University Press / USA
SN - 10966080
AB - The appropriate use and interpretation of cognitive tests presents important challenges to the toxicologist and to the risk assessor. For example, intelligence cannot be measured directly; rather intelligence is quantified indirectly by scoring responses (i.e., behaviors) to specific situations (problems). This workshop, “Cognitive Tests: Interpretation for Neurotoxicity?” provided an overview on the types of cognitive tests available and described approaches by which the validity of such tests can be assessed. Unlike many tools available to the toxicologist, cognitive tests have a particular advantage. Being noninvasive and species-neutral, the same test can be performed in different mammalian species. This enhances one's ability to assess the validity of test results. Criteria for test validity include comparable responses across species as well as similar disruption by the same neurotoxicant across species. Test batteries, such as the Operant Test Battery, have indicated remarkable similarity between monkeys and children with respect to performance of certain tasks involving, for example, short-term memory. Still, there is a need for caution in interpretation of such tests. In particular, cognitive tests, especially when performed in humans, are subject to confounding by a range of factors, including age, gender, and, in particular, education. Moreover, the ability of such tests to reflect intelligence must be considered. Certain aspects of intelligence, such as the ability to plan or carry out specific tasks, are not well reflected by many of the standard tests of cognition. Nonetheless, although still under development, cognitive tests do hold promise for reliably predicting neurotoxicity in humans. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicologists
KW - Mammals
KW - Neurotoxicology
KW - Short-term memory
KW - Cognitive ability
KW - behavioral neurotoxicology
KW - cognitive tests
KW - metals
KW - neurobehavioral test battery
KW - solvents
N1 - Accession Number: 44611766; Slikker Jr., William 1; Beck, Barbara D. 2; Email Address: bbeck@gradientcorp.com; Cory-Slechta, Deborah A. 3; Paule, Merle G. 4; Anger, W. Kent 5; Bellinger, David 6; Affiliations: 1: National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, Arkansas 72079; 2: Gradient Corporation, 238 Main Street, Cambridge, Massachusetts 02142; 3: Department of Environmental Medicine, Box EHSC, University of Rochester Medical School, Rochester, New York 14642; 4: Behavioral Toxicology Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079-9502; 5: Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland, Oregon 97201; 6: Children's Hospital, Neuroepidemiology Unit, 300 Longwood Avenue, Carnegie 208, Boston, Massachusetts 02115; Issue Info: Dec2000, Vol. 58 Issue 2, p222; Thesaurus Term: Toxicologists; Thesaurus Term: Mammals; Subject Term: Neurotoxicology; Subject Term: Short-term memory; Subject Term: Cognitive ability; Author-Supplied Keyword: behavioral neurotoxicology; Author-Supplied Keyword: cognitive tests; Author-Supplied Keyword: metals; Author-Supplied Keyword: neurobehavioral test battery; Author-Supplied Keyword: solvents; Number of Pages: 13p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-06296-007
AN - 2002-06296-007
AU - Zuvekas, Samuel H.
T1 - Assessing state parity legislation.
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2000/12//
VL - 3
IS - 4
SP - 215
EP - 217
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Zuvekas, Samuel H., Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, 2101 E. Jefferson St.-Suite 500, Rockville, MD, US, 20852
N1 - Accession Number: 2002-06296-007. PMID: 11967458 Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, Rockville, MD, US. Release Date: 20021113. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Client Attitudes; Health Insurance; Laws; Mental Disorders. Minor Descriptor: Mental Health Services. Classification: Health & Mental Health Treatment & Prevention (3300). References Available: Y. Page Count: 3. Issue Publication Date: Dec, 2000.
AB - Notes that temptation is great, but premature, to conclude from the R. Sturm study (see record [rid]2002-06296-006[/rid]) that parity mandates had no effect on access and insurance coverage for the mentally ill. The study lacks statistical power for those directly covered by the mandates, and it is unlikely adequate power exists for those only indirectly affected. The inclusion of the uninsured, Medicaid enrollees, and privately covered individuals not subject to the mandates, and the imprecise outcome measures, increase the likelihood that other factors dominate parity. The timing of implementation in some states is also problematic. But Sturm asks the right questions and future waves of the Healthcare for Communities survey and other data will be better able to address them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state parity legislation
KW - changes in health insurance
KW - perceived access to care
KW - individuals with mental illness
KW - 2000
KW - Client Attitudes
KW - Health Insurance
KW - Laws
KW - Mental Disorders
KW - Mental Health Services
KW - 2000
DO - 10.1002/mhp.101
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-06296-007&site=ehost-live&scope=site
UR - szuvekas@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-06836-001
AN - 2001-06836-001
AU - Smith, Ron
T1 - Substance abuse treatment outcomes: Treatment practice and policy implications.
JF - Journal of Psychopathology and Behavioral Assessment
JO - Journal of Psychopathology and Behavioral Assessment
JA - J Psychopathol Behav Assess
Y1 - 2000/12//
VL - 22
IS - 4
SP - 299
EP - 307
CY - US
PB - Plenum Publishing Corp.
SN - 0882-2689
SN - 1573-3505
N1 - Accession Number: 2001-06836-001. Other Journal Title: Journal of Behavioral Assessment. Partial author list: First Author & Affiliation: Smith, Ron; US Dept of Health & Human Services (HHS), Ctr for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Office of Evaluation, Scientific Analysis, & Synthesis, Rockville, MD, US. Other Publishers: Springer. Release Date: 20010530. Correction Date: 20130422. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Health Care Psychology; Treatment Outcomes. Classification: Drug & Alcohol Rehabilitation (3383). Methodology: Literature Review. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2000.
AB - Provides a brief overview of the National Treatment Improvement Evaluation Study and briefly summarizes the other research papers included in this issue, all of which exemplify practice and policy issues in the substance abuse treatment field and bolster approaches applied to address these issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - evaluation
KW - services research
KW - National Improvement Evaluation Study
KW - treatment outcomes
KW - 2000
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Psychology
KW - Treatment Outcomes
KW - 2000
DO - 10.1023/A:1007637106156
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-06836-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-08600-003
AN - 2002-08600-003
AU - del Vecchio, Paolo
AU - Fricks, Larry
AU - Johnson, J. Rock
T1 - Issues of daily living for persons with mental illness.
JF - Psychiatric Rehabilitation Skills
JO - Psychiatric Rehabilitation Skills
Y1 - 2000///Win 2000
VL - 4
IS - 3
SP - 410
EP - 423
CY - United Kingdom
PB - Taylor & Francis
SN - 1097-3435
AD - del Vecchio, Paolo, Ctr for Mental Health Services, 5600 Fishers Lane, Room 17-C-02, Rockville, MD, US, 20857
N1 - Accession Number: 2002-08600-003. Other Journal Title: American Journal of Psychiatric Rehabilitation. Partial author list: First Author & Affiliation: del Vecchio, Paolo; Ctr for Mental Health Services, Washington, DC, US. Release Date: 20030303. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activities of Daily Living; Mental Disorders; Well Being. Minor Descriptor: Poverty; Consequence. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: Win 2000.
AB - Discusses difficulties that challenge the well being and daily living of persons with mental illness, including poverty and subsistence issues. People who experience mental illness are challenged not only by their illness, but also by the social consequences, which follow or even exacerbate their illness. The impact of poverty, homelessness, inadequate and unsafe housing, low quality or no physical health care, and lack of or interrupted education and unemployment on the lives of mental health consumers/survivors is incalculable. These social consequences are the 'side effects' which are seen to result from an inadequate system of care for persons with mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental illness
KW - social consequences
KW - daily living challenges
KW - poverty
KW - well being
KW - 2000
KW - Activities of Daily Living
KW - Mental Disorders
KW - Well Being
KW - Poverty
KW - Consequence
KW - 2000
DO - 10.1080/10973430008408631
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-08600-003&site=ehost-live&scope=site
UR - pdelvecc@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106993526
T1 - A prospective study of back belts for prevention of back pain and injury.
AU - Wassell JT
AU - Gardner LI
AU - Landsittel DP
AU - Johnston JJ
AU - Johnston JM
AU - Wassell, J T
AU - Gardner, L I
AU - Landsittel, D P
AU - Johnston, J J
AU - Johnston, J M
Y1 - 2000/12/06/
N1 - Accession Number: 106993526. Language: English. Entry Date: 20010126. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Orthoses -- Utilization
KW - Low Back Pain -- Prevention and Control
KW - Back Injuries -- Prevention and Control
KW - Organizational Policies
KW - Occupational-Related Injuries -- Prevention and Control
KW - Prospective Studies
KW - Regression
KW - Confidence Intervals
KW - Odds Ratio
KW - Relative Risk
KW - Worker's Compensation
KW - Self Report
KW - Adult
KW - Middle Age
KW - Male
KW - Female
KW - Human
SP - 2727
EP - 2732
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 284
IS - 21
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Despite scientific uncertainties about effectiveness, wearing back belts in the hopes of preventing costly and disabling low back injury in employees is becoming common in the workplace.Objective: To evaluate the effectiveness of using back belts in reducing back injury claims and low back pain.Design and Setting: Prospective cohort study. From April 1996 through April 1998, we identified material-handling employees in 160 new retail merchandise stores (89 required back belt use; 71 had voluntary back belt use) in 30 states (from New Hampshire to Michigan in the north and from Florida to Texas in the south); data collection ended December 1998, median follow-up was 6(1/2) months.Participants: A referred sample of 13,873 material handling employees provided 9377 baseline interviews and 6311 (67%) follow-up interviews; 206 (1.4%) refused baseline interview.Main Outcome Measures: Incidence rate of material-handling back injury workers' compensation claims and 6-month incidence rate of self-reported low back pain.Results: Neither frequent back belt use nor a belt-requirement store policy was significantly associated with back injury claim rates or self-reported back pain. Rate ratios comparing back injury claims of those who reported wearing back belts usually every day and once or twice a week vs those who reported wearing belts never or once or twice a month were 1.22 (95% confidence interval [CI], 0.87-1.70) and 0.95 (95% CI, 0.56-1.59), respectively. The respective odds ratios for low back pain incidence were 0.97 (95% CI, 0.83-1.13) and 0.92 (95% CI, 0.73-1.16).Conclusions: In the largest prospective cohort study of back belt use, adjusted for multiple individual risk factors, neither frequent back belt use nor a store policy that required belt use was associated with reduced incidence of back injury claims or low back pain. JAMA. 2000;284:2727-2732.
SN - 0098-7484
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Rd, Morgantown, WV 26505, USA
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morganton, WV
U2 - PMID: 11105177.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106993526&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107003757
T1 - A search for sex differences in response to analgesia.
AU - Averbuch M
AU - Katzper M
Y1 - 2000/12/11/
N1 - Accession Number: 107003757. Language: English. Entry Date: 20010302. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Supplement Title: 12/11/2000-12/25/2000. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Analgesia
KW - Pain Threshold
KW - Sex Factors
KW - Antiinflammatory Agents, Non-Steroidal -- Administration and Dosage
KW - Tooth Extraction
KW - Meta Analysis
KW - Questionnaires
KW - Data Analysis Software
KW - Chi Square Test
KW - Analysis of Variance
KW - T-Tests
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Female
KW - Male
KW - Education, Continuing (Credit)
KW - Human
SP - 3424
EP - 3509
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 160
IS - 22
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 11112235.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kapley, Atya
AU - Lampel, Keith
AU - Purohit, Hemant J.
T1 - Thermocycling steps and optimization of multiplex PCR.
JO - Biotechnology Letters
JF - Biotechnology Letters
Y1 - 2000/12/15/
VL - 22
IS - 24
M3 - Article
SP - 1913
EP - 1918
SN - 01415492
AB - Multiplex PCR (M-PCR), a method that detects more than two target loci in a single reaction, relies on the variables which influence single template specific PCR. We describe here the role of temperature cycles in ensuring the efficiency of detection. We have designed a multi-step protocol, which uses gradients between the temperature steps. This has facilitated the target specific annealing in the developed M-PCR. We have examined various thermocycling steps and optimized the M-PCR protocol using 105 to 101 cells of Escherichia coli, Salmonella typhi, and Vibrio cholera as template in a single reaction. The sensitivity of the detection observed was 102 cells of each pathogen used in the study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology Letters is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Pathogenic microorganisms
KW - Escherichia coli
KW - Polymerase chain reaction
KW - Vibrio infections
KW - Cells
KW - enteropathogens
KW - multi-step PCR
KW - multiplex PCR
KW - thermocycling steps
N1 - Accession Number: 15607674; Kapley, Atya 1; Lampel, Keith 2; Purohit, Hemant J. 1; Email Address: hemantdrd@hotmail.com; Affiliations: 1: National Environmental Engineering Research Institute, Nagpur 440 020, India.; 2: Food and Drug Administration, 200 C Street, Washington, DC 20204, USA.; Issue Info: Dec2000, Vol. 22 Issue 24, p1913; Thesaurus Term: Salmonella; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Escherichia coli; Subject Term: Polymerase chain reaction; Subject Term: Vibrio infections; Subject Term: Cells; Author-Supplied Keyword: enteropathogens; Author-Supplied Keyword: multi-step PCR; Author-Supplied Keyword: multiplex PCR; Author-Supplied Keyword: thermocycling steps; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huffman, L. J.
AU - Judy, D. J.
AU - Rao, K. M. K.
AU - Frazer, D. G.
AU - Goldsmith, W. T.
T1 - LUNG RESPONSES TO HYPOTHYROIDISM, HYPERTHYROIDISM, AND LIPOPOLYSACCHARIDE CHALLENGE IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2000/12/15/
VL - 61
IS - 7
M3 - Article
SP - 623
EP - 639
SN - 15287394
AB - The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on some factors involved in lung injury under basal conditions (air exposure) and during an inflammatory response induced by inhalation exposure to lipopolysaccharide (LPS; 100 µg/ml; 3 h) in adult rats. Thyroid status was altered by thyroidectomy or thyroxine injections for 15 d. Hyperthyroidism alone caused a greater degree of lung cell damage, an increase in the permeability of the alveolar–capillary barrier, a rise in the total number of phagocytic cells obtained by bronchoalveolar lavage (BAL), and enhanced nitric oxide (NO) release by phagocytic cells relative to that in euthyroid control animals. Hypothyroidism alone was associated with opposite effects. Exposure of animals to LPS produced inflammatory responses, which included significant increases in lung cell damage, permeability of the alveolar–capillary barrier, number of phagocytic cells obtained by BAL, and NO production by the phagocytic cells. In general, hyperthyroidism enhanced the effects of LPS, while hypothyroidism reduced LPS-induced responses. These results suggest that thyroid status alone can affect some of the factors involved in lung injury and also modulate some of the inflammatory effects of LPS. Hyperthyroidism tends to enhance lung injury, while hypothyroidism seems to reduce lung injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSIOLOGY
KW - Thyroid diseases
KW - Lungs
N1 - Accession Number: 4148647; Huffman, L. J. 1; Judy, D. J. 2; Rao, K. M. K. 2; Frazer, D. G. 1; Goldsmith, W. T. 2; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, and Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: 2000, Vol. 61 Issue 7, p623; Thesaurus Term: PHYSIOLOGY; Subject Term: Thyroid diseases; Subject Term: Lungs; Number of Pages: 17p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/00984100050194135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4148647&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reasor, Mark J.
AU - Antonini, James M.
T1 - PULMONARY RESPONSES TO SINGLE VERSUS MULTIPLE INTRATRACHEAL INSTILLATIONS OF SILICA IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2000/12/31/
VL - 62
IS - 1
M3 - Article
SP - 9
EP - 21
SN - 15287394
AB - The pulmonary toxicity of particles is often studied using a single intratracheal instillation of the material. It was hypothesized that smaller multiple intratracheal administrations of silica would result in differences in pulmonary responses as compared to a single large intratracheal administration. In the first of a series of experiments, the pulmonary responses in male F344 rats to a single intratracheal instillation of crystalline silica (5 mg/100 g body weight) given on d 0 were compared with those resulting from 5 consecutive daily intratracheal administrations of the dust (1 mg/100 g body weight/d) with the initial dose given on d 0. Controls received saline intratracheally. In the second experiment, the dose was reduced to 1 mg/100 g body weight for the single-dose protocol and 0.2 mg/100 g body weight/d for 5 consecutive days for the multiple-dose protocol. In both experiments, responses were assessed on d 14. In the third experiment, the doses were the same as the first experiment, but the responses were assessed on d 28. The indices of toxicity were cellular differentials recovered by bronchoalveolar lavage, which is an index of inflammation, and the level of albumin in the bronchoalveolar lavage fluid, a measure of damage to the capillary–epithelial barrier. At the higher dose of silica, similar levels of inflammation and lung damage were evident in both dosing protocols. Less severe responses occurred at the lower dose. The comparative pattern between the single and multiple dosing protocols was similar in all three experiments. Since only minor differences were noted in the pulmonary responses when the responses to the single- and multiple-dose protocols were compared, data indicate that the multiple-dose protocol does not offer any advantages over the single-dose protocol. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pulmonary toxicology
KW - Silica
KW - Rats as laboratory animals
N1 - Accession Number: 4783522; Reasor, Mark J. 1; Antonini, James M. 2; Affiliations: 1: Department of Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown, West Virginia, USA; 2: National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA; Issue Info: 2001, Vol. 62 Issue 1, p9; Subject Term: Pulmonary toxicology; Subject Term: Silica; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/00984100050201631
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107030342
T1 - Respiratory protection as a function of respirator fitting characteristics and fit-test accuracy.
AU - Campbell DL
AU - Coffey CC
AU - Lenhart SW
Y1 - 2001/01//2001 Jan-Feb
N1 - Accession Number: 107030342. Language: English. Entry Date: 20010615. Revision Date: 20150711. Publication Type: Journal Article; algorithm; pictorial; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100939625.
KW - Respiratory Protective Devices -- Evaluation
KW - Occupational Safety -- Standards
KW - Product Evaluation
KW - Models, Theoretical
KW - Equipment Maintenance
KW - Measurement Error
KW - Measurement Issues and Assessments
KW - Predictive Value of Tests
SP - 36
EP - 44
JO - AIHAJ
JF - AIHAJ
JA - AIHAJ
VL - 62
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The fitting characteristics of particulate respirators are no longer assessed in the National Institute for Occupational Safety and Health respirator certification program. It is important for respirator program administrators to understand the implications of that change and the additional burden it may impose. To address that issue, a typical respirator fit-testing program is analyzed using a mathematical model that describes the effectiveness of a fit-testing program as a function of the fitting characteristics of the respirator and the accuracy of the fit-testing method. The model is used to estimate (1) the respirator assignment error, the percentage of respirator wearers mistakenly assigned an ill-fitting respirator; (2) the number of fit-test trials necessary to qualify a group of workers for respirator use; and (3) the number of workers who will fail the fit-test with any candidate respirator model and thereby fail to qualify for respirator use. Using data from previous studies, the model predicts respirator assignment errors ranging from 0 to 20%, depending on the fitting characteristics of the respirator models selected and the fit-testing method used. This analysis indicates that when respirators do not necessarily have good fitting characteristics, respirator program administrators should exercise increased care in the selection of respirator models and increased care in fit-testing. Also presented are ways to assess the fitting characteristics of candidate respirator models by monitoring the first-time fit-testing results. The model demonstrates that significant public health and economic benefits can result when only respirators having good fitting characteristics are purchased and respirators are assigned to workers using highly accurate fit-testing methods.
SN - 1529-8663
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888
U2 - PMID: 11258866.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fox, Sarah A.
AU - Stein, Judith A.
AU - Sockloskie, Robert J.
AU - Ory, Marcia G.
T1 - Targeted Mailed Materials and the Medicare Beneficiary: Increasing Mammogram Screening Among the Elderly.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/01//
VL - 91
IS - 1
M3 - Article
SP - 55
EP - 61
PB - American Public Health Association
SN - 00900036
AB - Conclusions. A targeted low-cost mailed intervention can help increase screening rates among elderly minority women. The Health Care Financing Administration should promote its benefits aggressively if it expects to reach its target--elderly beneficiaries. (Am J Public Health. 2001;91:55-61) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Mammograms
KW - Cancer in women
KW - Breast cancer
KW - Medicare
KW - Medical screening
N1 - Accession Number: 3932822; Fox, Sarah A. 1,2; Email Address: sarah_fox@rand.org; Stein, Judith A. 3; Sockloskie, Robert J.; Ory, Marcia G. 4; Affiliations: 1: RAND, Santa Monica, Calif.; 2: Department of Medicine, School of Medicine, University of California, Los Angeles; 3: Department of Psychology, University of California, Los Angeles; 4: National Institute on Aging, US Department of Health and Human Services, Bethesda, Md.; Issue Info: Jan2001, Vol. 91 Issue 1, p55; Thesaurus Term: Health risk assessment; Subject Term: Mammograms; Subject Term: Cancer in women; Subject Term: Breast cancer; Subject Term: Medicare; Subject Term: Medical screening; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 7p; Document Type: Article
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ER -
TY - JOUR
AU - Pappas, Gregory
AU - Akhtar, Taslim
AU - Gergen, Peter J.
AU - Hadden, Wilbur C.
AU - Khan, Abdul Qayyum
T1 - Health Status of the Pakistani Population: A Health Profile and Comparison With the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/01//
VL - 91
IS - 1
M3 - Article
SP - 93
EP - 98
PB - American Public Health Association
SN - 00900036
AB - Conclusions. There are major inequalities in health within Pakistan and between Pakistan and the United States. Standardized national health examination survey methodology can be used to monitor health status and plan health transition policy in developing countries. (Am J Public Health. 2001 ;91: 93-98) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Public health
KW - Population
KW - Pakistanis
KW - Americans
KW - Pakistan
KW - United States
N1 - Accession Number: 3933056; Pappas, Gregory 1; Akhtar, Taslim 2; Gergen, Peter J. 3; Hadden, Wilbur C. 4; Email Address: wch2@cdc.gov; Khan, Abdul Qayyum 5; Affiliations: 1: Office of the Assistant Secretary for Health, Washington, DC; 2: Khyber Medical College, Peshawar, Pakistan; 3: Agency for Healthcare Research and Quality, Rockville, Md.; 4: National Center for Health Statistics, Centers for Disease Control and Prevention Hyattsville, Md.; 5: Pakistan Medical Research Council, Islamabad; Issue Info: Jan2001, Vol. 91 Issue 1, p93; Thesaurus Term: HEALTH; Thesaurus Term: Public health; Thesaurus Term: Population; Subject Term: Pakistanis; Subject Term: Americans; Subject: Pakistan; Subject: United States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - England, Ellen
AU - Key-Schwartz, Rosa
AU - Lesage, Jacques
AU - Carlton, Gary
AU - Streicher, Robert
AU - Song, Ruiguang
T1 - Erratum to "Comparison of Sampling Methods for Monomer and Polyisocyanates of 1,6-Hexamethylene Diisocyanate During Spray Finishing Operations" [Appl Occup Env Hyg 15(6):472-478].
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/01//
VL - 16
IS - 1
M3 - Correction notice
SP - 1
EP - 1
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Presents an erratum of the article 'Comparison of Sampling Methods for Monomer and Polyisocyanates of 1,6-Hexamethylene Diisocyanate During Spray Finishing Operations.'
KW - Monomers
KW - Analytical chemistry
N1 - Accession Number: 4230204; England, Ellen 1; Key-Schwartz, Rosa 2; Lesage, Jacques 3; Carlton, Gary 1; Streicher, Robert 2; Song, Ruiguang 2; Affiliations: 1: Institute for Environment, Safety and Occupational Health Risk Analysis, Brooks Air Force Base, Texas; 2: Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Institut de Recherche en Santé et en Sécuritédu Travail du Québec (IRSST) Montreal Quebec, Canada; Issue Info: Jan2001, Vol. 16 Issue 1, p1; Thesaurus Term: Monomers; Thesaurus Term: Analytical chemistry; Number of Pages: 1p; Illustrations: 1 Chart, 1 Graph; Document Type: Correction notice
L3 - 10.1080/104732201456069
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
AU - Berger, Vance
AU - Ivanova, Anastasia
AD - US Food and Drug Administration
AD - U NC
A2 - Millard, Steven P.
A2 - Krause, Andreas
T1 - Permutation Tests for Phase III Clinical Trials
T2 - Applied statistics in the pharmaceutical industry: With case studies using S-Plus
PB - Heidelberg and New York:
PB - Springer
Y1 - 2001///
SP - 349
EP - 374
N1 - Accession Number: 0659351; Reviewed Book ISBN: 3-387-98814-9; ; Publication Type: Collective Volume Article; Update Code: 200309
KW - Analysis of Health Care Markets I11
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 107007892
T1 - Applying the Diabetes Quality Improvement Project indicators in the Indian Health Service primary care setting.
AU - Acton KJ
AU - Shields R
AU - Rith-Najarian S
AU - Tolbert B
AU - Kelly J
AU - Moore K
AU - Valdez L
AU - Skipper B
AU - Gohdes D
Y1 - 2001/01//
N1 - Accession Number: 107007892. Language: English. Entry Date: 20010316. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975.
KW - Quality Improvement
KW - Clinical Indicators
KW - Primary Health Care -- Evaluation
KW - Health Services, Indigenous -- Evaluation
KW - Diabetes Mellitus -- Therapy
KW - Native Americans
KW - Random Sample
KW - Confidence Intervals
KW - Record Review
KW - Mantel-Haenszel Test
KW - Chi Square Test
KW - P-Value
KW - Hemoglobin A, Glycosylated -- Analysis
KW - Blood Pressure Determination
KW - Prospective Studies
KW - Human
SP - 22
EP - 26
JO - Diabetes Care
JF - Diabetes Care
JA - DIABETES CARE
VL - 24
IS - 1
CY - Alexandria, Virginia
PB - American Diabetes Association
AB - OBJECTIVE: With publication of the Diabetes Quality Improvement Project (DQIP) measures, the Indian Health Service National Diabetes Program applied the DQIP format to its IHS Diabetes Care and Outcomes Audit for comparison and benchmarks. RESEARCH DESIGN AND METHODS: Since 1986 the IHS Diabetes Care and Outcomes Audit has been conducted by medical record review in >75% of IHS and tribal facilities. Each year systematic random sample of charts is drawn from local diabetes registries. Chart reviews are conducted by, trained professionals according to standard definitions and instructions. Abstracted data are entered into a microcomputer-based epidemiologic software package. Local, regional, and national rates are constructed for each item. During the period 1995-1997, 150 facilities submitted data for compilation, representing participation from all 12 IHS administrative regions. The IHS Diabetes Care and Outcomes Audit collected virtually all of the DQIP measures, with the exception of LDL cholesterol (which was added to the record review in 1998). RESULTS: In 1995, 1996, and 1997, a total of 9,557, 9,985, and 9,626 individuals, respectively, were included in the total IHS audit sample. The reviews for 1995, 1996, and 1997 revealed that of all subjects: 55, 65, and 80%, respectively, had more than one HbA1c test during the year (P < 0.001); 42, 38, and 34%, respectively; had a high-risk HbA1c (>9.5%) (P < 0.001); 83, 81, and 84%, respectively, were tested for macroproteinuria (P < 0.11) and 16, 17, and 23%, respectively were tested for microproteinuria (P < 0.001); total cholesterol was assessed in 80, 81, and 85%, respectively (P < 0.001), and corresponding proportions of those with values <5.17 mmol/l were 48, 50, and 52%, respectively; triglyceride values were measured for 75,75, and 80%, respectively (P < 0.001), and the corresponding median triglyceride levels were 199, 198, and 193 mg/dl, respectively (P < 0.001); the proportion of clients with a blood pressure <140/90 mmHg was 64, 64, and 66%, respectively (P < 0.05); 55, 56, and 55%, respectively, had a dilated eye exam (P < 0.053); and the proportion of clients who had a comprehensive foot exam were 59, 59, and 61%, respectively (P < 0.05). CONCLUSIONS: The DQIP accountability and quality improvement measures could be easily applied to the IHS Diabetes Care and Outcomes Audit, and the process can prove to be practical. However, data alone are not sufficient to effect change. Use of the measures to ensure that the quality of care improves must also be stressed, because measuring alone will not guarantee such improvement.
SN - 0149-5992
AD - Indian Health Service National Diabetes Program, Albuquerque, New Mexico
U2 - PMID: 11194234.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2008-17779-006
AN - 2008-17779-006
AU - Hurrell, Joseph J. Jr.
ED - Perrewé, Pamela L.
ED - Ganster, Daniel C.
ED - Perrewé, Pamela L., (Ed)
ED - Ganster, Daniel C., (Ed)
T1 - Psychosocial factors and musculoskeletal disorders.
T2 - Exploring theoretical mechanisms and perspectives.
T3 - Research in occupational stress and well being; Vol 1; ISSN: 1479-3555 (Print)
Y1 - 2001///
VL - 1
SP - 233
EP - 256
CY - US
PB - Elsevier Science/JAI Press
SN - 1479-3555
SN - 0-7623-0846-X
SN - 978-0-7623-0846-0
N1 - Accession Number: 2008-17779-006. Partial author list: First Author & Affiliation: Hurrell, Joseph J. Jr.; Science, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, US. Release Date: 20090706. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-0846-X, Hardcover; 978-0-7623-0846-0, Hardcover. Language: English. Major Descriptor: Musculoskeletal Disorders; Psychosocial Factors. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24.
AB - The term musculoskeletal disorders (MSDs) refers to conditions that involve the nerves, tendons, muscles and supporting structures of the body. Such disorders represent a tremendous occupational health problem in the United States. According to Bureau of Labor Statistics data (National Academy of Sciences, 2001), nearly 1 million people each year report that they take time away from work to treat and recover from musculoskeletal pain or loss of function due to overexertion or repetitive motion. In 1999, musculoskeletal-related injuries accounted for fully 34.2% of all new injuries and illnesses, involving days away from work, to employees in the U.S. private sector. (Bureau of Labor Statistics, 1999). In addition to the human suffering caused by these disorders, the estimated workers' compensation costs associated with lost work days resulting from these disorders range from $13 (NIOSH, 1996) to $20 billion (AFL-CIO, 1997), annually. How workplace conditions precipitate MSDs is not currently understood (see Kumar, 2001). However, a substantial body of epidemiologic research provides clear evidence of an association between certain work-related physical factors (e.g. force, repetition and static posture) and MSDs; especially when there are high levels of exposure and when there is exposure to more than one physical factor (see Bernard, 1997; National Academy of Sciences, 2001). 'Psychosocial factors' have also been acknowledged as playing an important role in the etiology of these disorders (see Bernard, 1997; National Academy of Sciences, 2001). This chapter will examine research evidence linking psychosocial factors (particularly work-related psychosocial factors) to MSDs of the upper extremities and back. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial factors
KW - musculoskeletal disorders
KW - 2001
KW - Musculoskeletal Disorders
KW - Psychosocial Factors
KW - 2001
DO - 10.1016/S1479-3555(01)01014-9
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107012469
T1 - Concise communications. Invasive aspergillosis outbreak on a hematology-oncology ward.
AU - Burwen DR
AU - Lasker BA
AU - Rao N
AU - Durry E
AU - Padhye AA
AU - Jarvis WR
Y1 - 2001/01//2001 Jan
N1 - Accession Number: 107012469. Language: English. Entry Date: 20010406. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8804099.
KW - Aspergillosis -- Epidemiology
KW - Disease Outbreaks
KW - Aspergillosis -- Etiology
KW - Cross Infection
KW - Epidemiological Research
KW - Disease Surveillance
KW - Aspergillosis -- Blood
KW - Fisher's Exact Test
KW - Kruskal-Wallis Test
KW - DNA Probes
KW - Electrophoresis
KW - Relative Risk
KW - Oncology Care Units
KW - Pennsylvania
KW - Risk Factors
KW - Neutropenia -- Complications
KW - Inpatients
KW - Human
SP - 45
EP - 48
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 22
IS - 1
PB - Cambridge University Press
AB - An outbreak of invasive aspergillosis occurred in a community hospital in temporal association with construction activity. Epidemiological investigation showed that patients who are at highest risk comprise a small group and are readily identifiable. Clinicians should strive to protect these patients, following guidelines published by the Centers for Disease Control and Prevention.
SN - 0899-823X
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, Atlanta, GA
U2 - PMID: 11198023.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Clarke, Robert W.
T1 - STRAIN-RELATED DIFFERENCES OF NONSPECIFIC RESPIRATORY DEFENSE MECHANISMS IN RATS USING A PULMONARY INFECTIVITY MODEL.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2001/01//
VL - 13
IS - 1
M3 - Article
SP - 85
EP - 102
SN - 08958378
AB - A number of animal studies have assessed pulmonary host defense mechanisms by inoculating the lungs with the bacterial agent, Listeria monocytogenes. Most studies use only a single strain of the animal to be tested; however, strain-related differences in responsiveness to pulmonary toxicants have been well documented. It was the goal of this current investigation to measure the pulmonary defense responses of two different strains of rats in a lung infectivity model. Fischer 344 (F344) and Sprague-Dawley (SD) rats were instilled intratracheally with 5 × 10[sup 3] or 5 × 10[sup 5] L. monocytogenes, and the effect on mortality, lung injury and inflammation, pulmonary bacterial clearance, and alveolar macrophage (AM) function was determined at 3, 5, and 7 days after bacteria treatment. Pulmonary inoculation with the higher (5 × 10[sup 5] L. monocytogenes ) dose proved to be highly pneumotoxic to the F344 rats as evidenced by an increase in mortality and more severe lung injury and inflammation when compared with the SD rats. After intratracheal instillation with the lower (5 × 10[sup 3] L. monocytogenes ) dose, pulmonary bacterial clearance was slowed and an increase in pulmonary responsiveness was observed for the F344 rats as compared to the SD rats. Specifically, the total number of neutrophils recovered from the lungs and tumor necrosis factor-α secreted by AMs were elevated for the F344 group throughout the 7 days, while cellular chemiluminescence, an index of reactive oxygen species production, and lung albumin and lactate dehydrogenase, indicators of injury, were increased at 3 and 5 days after bacterial instillation. This study demonstrated that respiratory defense function was compromised in F344 rats as evidenced by elevated mortality, slowed pulmonary bacterial clearance, and altered AM function. F344 rats may then represent a sensitive model for the examination of respiratory defense mechanisms after bacterial challenge. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Defense reaction (Physiology)
KW - Pulmonary toxicology
N1 - Accession Number: 4050865; Antonini, James M. 1; Roberts, Jenny R. 1; Clarke, Robert W. 2; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA; Issue Info: Jan2001, Vol. 13 Issue 1, p85; Subject Term: Defense reaction (Physiology); Subject Term: Pulmonary toxicology; Number of Pages: 18p; Illustrations: 4 Black and White Photographs, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1080/089583701459083
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schwetz, Bernard A.
T1 - Toxicology at the Food and Drug Administration: New Century, New Challenges.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2001/01//
VL - 20
IS - 1
M3 - Article
SP - 3
EP - 8
PB - Taylor & Francis Ltd
SN - 10915818
AB - Comments on the future needs of expertise within the field of toxicology. Emphasis on environmental and consumer safety issues; Role of toxicology in the development of safety products and wholesome foods; Importance of toxicological data for setting occupational standards.
KW - Toxicology
KW - Commercial products -- Testing -- Environmental aspects
N1 - Accession Number: 4318738; Schwetz, Bernard A. 1; Affiliations: 1: Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Jan2001, Vol. 20 Issue 1, p3; Thesaurus Term: Toxicology; Subject Term: Commercial products -- Testing -- Environmental aspects; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1080/109158101750103297
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107011137
T1 - From the Food and Drug Administration. Defibrillators: past, present, and problems.
AU - Gallauresi BA
Y1 - 2001/01//2001 Jan-Mar
N1 - Accession Number: 107011137. Language: English. Entry Date: 20010330. Revision Date: 20150820. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Defibrillators
KW - Defibrillators -- History
KW - Defibrillators -- Adverse Effects
KW - United States Food and Drug Administration
KW - Product Surveillance
SP - 23
EP - 25
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 7
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Nurse Consultant, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Product Evaluation Branch II, Food and Drug Administration, 1350 Piccard Dr, Rockville, MD 20850. E-mail: bxg@cdrh.fda.gov
U2 - PMID: 11174767.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
AU - Miller, G. Edward
AU - Moeller, John
AD - Agency for Healthcare Research and Quality
AD - Agency for Healthcare Research and Quality
A2 - Farquhar, Irina
A2 - Summers, Kent
A2 - Sorkin, Alan
T1 - Outpatient Prescription Drug Prices and Insurance Coverage: An Analysis by Therapeutic Drug Class and User Characteristics from the 1996 Medical Expenditure Panel Survey
T2 - Investing in health: The social and economic benefits of health care innovation
PB - Research in Human Capital and Development, vol. 14.
PB - Amsterdam; New York and London:
PB - Elsevier Science, JAI
Y1 - 2001///
SP - 23
EP - 57
N1 - Accession Number: 0650817; Reviewed Book ISBN: 0-7623-0697-1; Keywords: Drug; Drugs; Insurance; Outpatient; Prescription; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200307
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Analysis of Health Care Markets I11
KW - Chemicals; Rubber; Drugs; Biotechnology L65
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 89462189
T1 - Measuring the incremental cost of clinical cancer research.
AU - Goldman, Dana P.
AU - Schoenbaum, Michael L.
AU - Potosky, Arnold L.
AU - Weeks, Jane C.
AU - Berry, Sandra H.
AU - Escarce, Jose J.
AU - Weidmer, Beverly A.
AU - Kilgore, Meredith L.
AU - Wagle, Nikhil
AU - Adams, John L.
AU - Figlin, Robert A.
AU - Lewis, Joy H.
AU - Cohen, Joel
AU - Kaplan, Richard
AU - McCabe, Mary
AU - Goldman, D P
AU - Schoenbaum, M L
AU - Potosky, A L
AU - Weeks, J C
AU - Berry, S H
Y1 - 2001/01//1/1/2001
N1 - Accession Number: 89462189. Language: English. Entry Date: 20010413. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins); Ways of Coping Questionnaire (WCQ) (Folkman et al). NLM UID: 8309333.
KW - Health and Welfare Planning
KW - Insurance Coverage
KW - Neoplasms -- Economics
KW - Insurance, Health
KW - Clinical Trials -- Economics
KW - Health Care Costs
KW - Health Services Accessibility
KW - Retrospective Design
KW - United States
KW - Human
KW - Study Design
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Scales
KW - Ways of Coping Questionnaire
SP - 105
EP - 110
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 1
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: To summarize evidence on the costs of treating patients in clinical trials and to describe the Cost of Cancer Treatment Study, an ongoing effort to produce generalizable estimates of the incremental costs of government-sponsored cancer trials.Methods: A retrospective study of costs will be conducted with 1,500 cancer patients recruited from a randomly selected sample of institutions in the United States. Patients accrued to either phase II or phase III National Cancer Institute-sponsored clinical trials during a 15-month period will be asked to participate in a study of their health care utilization (n = 750). Costs will be measured approximately 1 year after their trial enrollment from a combination of billing records, medical records, and an in-person survey questionnaire. Similar data will be collected for a comparable group of cancer patients not in trials (n = 750) to provide an estimate of the incremental cost.Results: Evidence suggests insurers limit access to trials because of cost concerns. Public and private efforts are underway to change these policies, but their permanent status is unclear. Previous studies found that treatment costs in clinical trials are similar to costs of standard therapy. However, it is difficult to generalize from these studies because of the unique practice settings, insufficient sample sizes, and the exclusion of potentially important costs.Conclusion: Denials of coverage for treatment in a clinical trial limit patient access to trials and could impede clinical research. Preliminary estimates suggest changes to these policies would not be expensive, but these results are not generalizable. The Cost of Cancer Treatment Study is an ongoing effort to provide generalizable estimates of the incremental treatment cost of phase II and phase III cancer trials. The results should be of great interest to insurers and the research community as they consider permanent ways to finance cancer trials.
SN - 0732-183X
AD - RAND, Santa Monica, CA
AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD
AD - Division of Cancer, Treatment, and Diagnosis, National Cancer Institute, Bethesda, MD
AD - Office of Education and Special Initiatives, National Cancer Institute, Bethesda, MD
AD - Dana-Farber Cancer Institute, Boston, MA
AD - Johnson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD
AD - RAND, Santa Monica, CA 90407-2138, USA
U2 - PMID: 11134202.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roe, Brian
AU - Teisl, Mario F.
AU - Levy, Alan S.
AU - Boyle, Kevin
AU - Messonnier, Mark L.
AU - Riggs, T. Lynn
AU - Herrmann, Melissa J.
AU - Newman, Felicia M.
T1 - Consumers' Assessment of the Food Safety Problem for Meals Prepared at Home and Reactions to Food Safety Labeling.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2001/01//
VL - 6
IS - 4
M3 - Article
SP - 9
SN - 10454446
AB - Public awareness and concern regarding foodborne illnesses have increased rapidly over the past decade. This increased concern may cause consumers to avoid certain stores, products or brands, particularly following a publicized incidence of foodborne illness or a large recall. Many firms have undertaken costly efforts to improve the safety of their products yet find communicating such improvements difficult because of potential alarmist responses by consumers to food safety issues. To identify if differences in food safety risks can be effectively and credibly communicated, we conducted eight focus groups. This article summarizes these focus groups and reports how consumers frame the issues surrounding the food safety problem and how consumers react to label-based communications of food safety characteristics. We find consumers have broad, moderate food safety concerns, a wide but spotty understanding of foodborne illness prevention and consequences, and a healthy skepticism concerning food safety claims. We identify two forms of labeling that show promise with regard to consumer acceptance and credibility in communicating brand-level and package-level differences in the risk of foodborne illness and discuss implications for consumer valuation of such differences. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Food Products Marketing is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD industry
KW - CONSUMER behavior
KW - BUSINESS enterprises
KW - AGRICULTURAL processing industries
KW - AGRICULTURAL industries
KW - FOOD handling
KW - FOODBORNE diseases
KW - COMMUNICABLE diseases
KW - FOOD pathogens
KW - focus group
KW - Food safety
KW - labeling
KW - risk communication
N1 - Accession Number: 27644684; Roe, Brian 1; Teisl, Mario F. 2; Levy, Alan S. 3; Boyle, Kevin 4; Messonnier, Mark L. 5; Riggs, T. Lynn 6; Herrmann, Melissa J. 7; Newman, Felicia M. 8; Affiliations: 1: Assistant Professor, Ohio State University, Room 225, 2120 Fyffe Road, Columbus, OH 43210.; 2: Assistant Professor, University of Maine, 200 Winslow Hall, Orono, ME 04469-5782.; 3: Consumer Studies Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 200 C Street, SW, Washington, DC 20205.; 4: Libra Professor of Environmental Economics, University of Maine, 200 Winslow Hall, Orono, ME 04469-5782.; 5: Chief, Prevention Effectiveness Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.; 6: Economist, Prevention Effectiveness Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333.; 7: Vice President of Social Science Research, International Communications Research, 605 West State Street, Media, PA 19063-2620.; 8: Focus Group Moderator, Newman Marketing Research, 11 Stony Brook Blvd., Newtown Square, PA 19073.; Issue Info: 2001, Vol. 6 Issue 4, p9; Thesaurus Term: FOOD industry; Thesaurus Term: CONSUMER behavior; Thesaurus Term: BUSINESS enterprises; Thesaurus Term: AGRICULTURAL processing industries; Thesaurus Term: AGRICULTURAL industries; Subject Term: FOOD handling; Subject Term: FOODBORNE diseases; Subject Term: COMMUNICABLE diseases; Subject Term: FOOD pathogens; Author-Supplied Keyword: focus group; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: labeling; Author-Supplied Keyword: risk communication; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Encinosa, William
T1 - The economics of regulatory mandates on the HMO market.
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2001/01//
VL - 20
IS - 1
M3 - Article
SP - 85
EP - 107
SN - 01676296
AB - Recently proposed HMO regulations have involved mandates of two forms: (1) minimum quality standards, and (2) mandated increases in access to speciality care. I show that piecemeal regulation, which uses only one of either mandate (1) or (2), may decrease welfare for all HMO consumers. Under full regulation using both (1) and (2), if the minimum standard is set too low, say, due to political bargaining, a floor-to-ceiling effect occurs. This involves HMOs setting quality at the minimum standard, even when their quality would be above the standard in an unregulated market. Finally, I show how premiums may either increase or decrease under a mandate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH maintenance organizations
KW - MANDATES (Territories)
KW - QUALITY standards
KW - CONSUMERS
KW - MARKETS
KW - MEDICAL care
KW - Adverse selection
KW - Health insurance regulation
KW - Minimum standards
N1 - Accession Number: 11943617; Encinosa, William 1; Email Address: wencinos@ahrq.gov; Source Information: Jan2001, Vol. 20 Issue 1, p85; Subject: HEALTH maintenance organizations; Subject: MANDATES (Territories); Subject: QUALITY standards; Subject: CONSUMERS; Subject: MARKETS; Subject: MEDICAL care; Author-Supplied Keyword: Adverse selection; Author-Supplied Keyword: Health insurance regulation; Author-Supplied Keyword: Minimum standards; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107054285
T1 - The impact of health status on work, symptoms, and functional outcomes in severe mental illness.
AU - Dixon L
AU - Goldberg R
AU - Lehman A
AU - McNary S
Y1 - 2001/01//
N1 - Accession Number: 107054285. Language: English. Entry Date: 20010928. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF 36); Lehman Quality of Life (QOL); Positive and Negative Symptom Scale (PANSS) (Kay et al). NLM UID: 0375402.
KW - Mental Disorders, Chronic -- Complications
KW - Attitude to Illness
KW - Consumer Satisfaction
KW - Health Status
KW - Scales
KW - Self Report
KW - Clinical Trials
KW - Regression
KW - Comorbidity
KW - Semi-Structured Interview
KW - Kappa Statistic
KW - Videorecording
KW - Descriptive Statistics
KW - Chi Square Test
KW - P-Value
KW - Power Analysis
KW - Odds Ratio
KW - Adult
KW - Human
SP - 17
EP - 23
JO - Journal of Nervous & Mental Disease
JF - Journal of Nervous & Mental Disease
JA - J NERV MENT DIS
VL - 189
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - This study evaluated the relationships between self-ratings of physical role functioning and general health, two components of the MOS SF-36, and a variety of demographic, quality of life, clinical, functional, and attitudinal variables in a cohort of adults living with severe and persistent mental illness (SPMI). We hypothesized that poorer self-perceptions of physical functioning and general health would be significantly related to more severe symptoms and poorer functioning and quality of life. Study subjects were 218 adults with SPMI enrolled in a randomized controlled trial comparing two vocational interventions for persons who were unemployed. Hierarchical regression analysis was used to determine whether psychiatric symptoms, poorer self-perceptions of role limitations due to physical health problems and overall general health independently contributed to more severe symptoms and poorer functioning and quality of life. Psychiatric symptoms were inversely related to size of social network and satisfaction with safety. Increased role limitations were associated with reduced medication compliance, general life satisfaction, and satisfaction with health, daily activities, and safety. Reduced general health was significantly associated with reduced work motivation, self-esteem, current inability to work, self-report of functioning, and almost all subjective life satisfaction domains. Within this group of people with severe mental illness, psychiatric symptoms were minimally associated with outcomes. Physical role limitations contributed more, and an integrated global measure of overall health perception was most important. If we are to help persons with severe mental illness maximize their quality of life and functioning, our clinical interventions should employ an approach that appreciates and recognizes the importance of the patients' experience of a holistic and integrated experience of health.
SN - 0022-3018
AD - University of Maryland, Center for Mental Health Services Research, 701 West Pratt Street, Room 476, Baltimore, Maryland 21201
U2 - PMID: 11206660.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107030874
T1 - Factors predicting orofacial pain patient satisfaction with improvement.
AU - Riley JL III
AU - Myers CD
AU - Robinson ME
AU - Bulcourf B
AU - Gremillion HA
Y1 - 2001///Winter2001
N1 - Accession Number: 107030874. Language: English. Entry Date: 20010615. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Beck Depression Inventory (BDI); Multidimensional Pain Inventory (MPI); State-Trait Anxiety Inventory (STAI) (Spielberger); Coping Strategies Questionnaire-Revised (CSQ-R); Short Form 36 Health Survey (SF-36)-Physical Functioning Subscale. Grant Information: Partially supported by NIH grants DE-07283 and 1P20DE12396-01. NLM UID: 9418507.
KW - Patient Satisfaction -- Evaluation
KW - Chronic Pain -- Therapy
KW - Coping Strategies Questionnaire
KW - Prospective Studies
KW - Pretest-Posttest Design
KW - Academic Medical Centers
KW - Florida
KW - Male
KW - Female
KW - Adult
KW - Middle Age
KW - Aged
KW - Pain Clinics
KW - Self Report
KW - McGill Pain Questionnaire
KW - Questionnaires
KW - Psychological Tests
KW - State-Trait Anxiety Inventory
KW - Clinical Assessment Tools
KW - Telephone
KW - Structured Interview
KW - Data Analysis Software
KW - Regression
KW - Dependent Variable
KW - Statistical Significance
KW - Descriptive Statistics
KW - Severity of Illness Indices
KW - Funding Source
KW - Human
SP - 29
EP - 35
JO - Journal of Orofacial Pain
JF - Journal of Orofacial Pain
JA - J OROFACIAL PAIN
VL - 15
IS - 1
CY - Hanover Park, Illinois
PB - Quintessence Publishing Company Inc.
AB - Aims: To determine psychosocial predictors of patients' ratings of satisfaction with improvement and subjective pain relief. This study also examined the underlying components of patient satisfaction with improvement, as assessed at follow-up. Methods: The sample consisted of 107 chronic orofacial pain patients evaluated at a university-based orofacial pain clinic and referred for treatment with individualized treatment plans. Pain and psychosocial functioning were assessed with standard, reliable, validated self-report instruments administered at the initial evaluation. Follow-up data were collected via a telephone-administered structured interview 8 months after the initial evaluation. Regression methodology was used to determine prediction models for satisfaction with improvement and subjective pain relief. Patient ratings of the quality of the caregiver communication were used as a control variable in all analyses. Results: Quality of caregiver communication predicted approximately 10 to 14% of the variance in outcomes in all models. Greater initial use of cognitive coping strategies and reduced depression predicted higher ratings of satisfaction with improvement and increased pain relief. When concurrent relationships among variables at the follow-up were examined, greater subjective pain relief since the evaluation, lower current pain, and higher ratings of overall mood were significant predictors of patient satisfaction with improvement. Conclusion: This study is one of the first to report that the use of certain cognitive coping strategies is associated with positive outcome for patients suffering from orofacial pain. These findings underscore the importance of individual differences on behavioral and psychosocial parameters in the prediction of patients' subjective evaluation of treatment outcome.
SN - 1064-6655
AD - Assistant Professor, Division of Public Health Service and Research, College of Dentistry, PO Box 100404 HSC, University of Florida, Gainesville, FL 32610-0404; jriley@dental.ufl.edu
U2 - PMID: 11889645.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Parascandola, John L.
AU - Parascandola, J L
T1 - Alice Catherine Evans (1881-1975).
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 2001/01//
VL - 22
IS - 1
M3 - journal article
SP - 105
EP - 111
SN - 01975897
AB - Presents an obituary for Alice Catherine Evans, microbiologist who played a crucial role in the recognition of the disease brucellosis.
KW - Animals
KW - Microbiology -- History
KW - Brucellosis
KW - History
KW - United States
KW - Evans, Alice Catherine, 1881-1975
N1 - Accession Number: 9167335; Parascandola, John L. 1; Parascandola, J L 2; Affiliations: 1: Public Health Service Historian, U.S. Public Health Service, 5600 Fishers Lane, Room 18-23, Rockville, Maryland 20857; 2: U.S. Public Health Service, 5600 Fishers Lane, Room 18-23, Rockville, Maryland 20857, USA; Issue Info: 2001, Vol. 22 Issue 1, p105; Thesaurus Term: Animals; Subject Term: Microbiology -- History; Subject Term: Brucellosis; Subject Term: History; Subject: United States; People: Evans, Alice Catherine, 1881-1975; Number of Pages: 7p; Document Type: journal article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106891684
T1 - Asthma outcomes at an inner-city school-based health center.
AU - Lurie N
AU - Bauer EJ
AU - Brady C
Y1 - 2001/01//
N1 - Accession Number: 106891684. Language: English. Entry Date: 20020118. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Instrumentation: Family Asthma Survey. Grant Information: Allina Foundation. NLM UID: 0376370.
KW - Asthma -- Therapy -- In Infancy and Childhood
KW - School Health Services
KW - Community Health Centers
KW - Outcomes (Health Care)
KW - Funding Source
KW - Evaluation Research
KW - Prospective Studies
KW - Cross Sectional Studies
KW - Pretest-Posttest Design
KW - Surveys
KW - Interviews
KW - Parents
KW - Physicians
KW - Questionnaires
KW - Research Instruments
KW - Treatment Outcomes
KW - Students, Elementary
KW - Health Screening
KW - Patient Care Plans
KW - Asthma -- Education
KW - Patient Education
KW - Medication Compliance
KW - Severity of Illness
KW - Health Resource Utilization
KW - Hospitalization
KW - Emergency Service -- Utilization
KW - Absenteeism
KW - Home Environment
KW - Insurance, Health
KW - Chi Square Test
KW - T-Tests
KW - Multivariate Statistics
KW - Logistic Regression
KW - P-Value
KW - Socioeconomic Factors
KW - Schools, Elementary
KW - Poverty Areas
KW - Age Factors
KW - Race Factors
KW - Child
KW - Blacks
KW - Hispanics
KW - Native Americans
KW - Whites
KW - Asians
KW - Minnesota
KW - Human
SP - 9
EP - 16
JO - Journal of School Health
JF - Journal of School Health
JA - J SCH HEALTH
VL - 71
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Childhood asthma has reached near-epidemic levels in the US cities. Innovative strategies to identify children with asthma and prevent asthma morbidity are needed. This study measured asthma outcomes after initiation of an inner-city elementary school health center with a schoolwide focus on asthma detection and treatment. The site was an inner-city elementary school in Minneapolis, Minn. The study design incorporated a pre and post comparison with a longitudinal cohort of children (n = 67) and a cross-sectional cohort of children before (n = 156) and after (n = 114) the intervention. Hospitalization rates for asthma decreased 75% to 80% over the study period. Outpatient visits for care in the absence of asthma symptoms doubled (p < .01), and the percentage of students seeing a specialist for asthma increased (p < .01). Use of peak flow meters, use of asthma care plans, and use of inhalers also improved (p < .01). While no change occurred in school absenteeism, parents reported that their children had less awakening with asthma and that asthma was less disruptive to family plans. This schoolwide intervention that included identification of children with asthma, education, family support, and clinical care using an elementary school health center was effective in improving asthma outcomes for children.
SN - 0022-4391
AD - Principal Deputy Assistant Secretary for Health, US Department of Health and Human Services, 200 Independence Ave., SW, Room 716-G, Washington, DC 20201. E-mail: nlurie@osophs.dhhs.gov
U2 - PMID: 11221541.
DO - 10.1111/j.1746-1561.2001.tb06481.x
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DP - EBSCOhost
DB - rzh
ER -
TY -
AU - Ashery, Rebecca Sagar1
T1 - The Utilization of Technology in Graduate Schools of Social Work.
JO - Journal of Technology in Human Services
JF - Journal of Technology in Human Services
J1 - Journal of Technology in Human Services
PY - 2001/01//
Y1 - 2001/01//
VL - 18
IS - 1/2
CP - 1/2
M3 - Article
SP - 5
SN - 15228835
AB - Fifteen faculty from graduate schools of social work and staff from three social work organizations were interviewed by telephone for this qualitative study to describe utilization of technology. Schools were engaged in technology activities that ranged from basic to special technology projects. For the most part there was unevenness in the use of technology within each school and between schools. A number of themes emerged. Eleven recommendations are given to help schools to become leaders in the field of social work and technology. [ABSTRACT FROM PUBLISHER]
KW - Educational technology
KW - Social services
KW - Universities & colleges -- Graduate work
KW - High technology industries -- Employees
KW - Universities & colleges -- Faculty
KW - Junior colleges -- Faculty
KW - College teachers
KW - Nonprofit organizations
KW - School social work
KW - schools of social work
KW - Technology utilization
N1 - Accession Number: 27644462; Authors: Ashery, Rebecca Sagar 1; Affiliations: 1: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention; Subject: Social services; Subject: Universities & colleges -- Graduate work; Subject: High technology industries -- Employees; Subject: Educational technology; Subject: Universities & colleges -- Faculty; Subject: Junior colleges -- Faculty; Subject: College teachers; Subject: Nonprofit organizations; Subject: School social work; Author-Supplied Keyword: schools of social work; Author-Supplied Keyword: Technology utilization; Number of Pages: 14p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 106998172
T1 - Device safety. Safeguarding contrast media injections.
AU - Gallauresi BA
Y1 - 2001/01//
N1 - Accession Number: 106998172. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Contrast Media -- Administration and Dosage
KW - Phlebography -- Equipment and Supplies
KW - Syringes
KW - Embolism, Air -- Etiology
KW - Equipment Safety
KW - Middle Age
KW - Male
KW - Outpatients
SP - 24
EP - 24
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 11216238.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107048956
T1 - Crystalline silica exposure and lung cancer mortality in diatomaceous earth industry workers: a quantitative risk assessment.
AU - Rice FL
AU - Park R
AU - Stayner L
AU - Smith R
AU - Gilbert S
AU - Checkoway H
Y1 - 2001/01//
N1 - Accession Number: 107048956. Language: English. Entry Date: 20010831. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Silicon Compounds -- Adverse Effects
KW - Minerals -- Adverse Effects
KW - Occupational Exposure -- Adverse Effects
KW - Industry
KW - Lung Neoplasms -- Mortality
KW - Lung Neoplasms -- Epidemiology
KW - Male
KW - Whites
KW - California
KW - Cox Proportional Hazards Model
KW - Confidence Intervals
KW - United States Occupational Safety and Health Administration -- Standards
KW - Statistical Significance
KW - Time Factors
KW - Hispanics
KW - Retrospective Design
KW - Linear Regression
KW - Descriptive Statistics
KW - Record Review
KW - Data Analysis Software
KW - Incidence
KW - Epidemiological Research
KW - Relative Risk
KW - Prevalence
KW - Confounding
KW - Risk Assessment
KW - Human
SP - 38
EP - 45
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 58
IS - 1
PB - BMJ Publishing Group
AB - OBJECTIVE: To use various exposure-response models to estimate the risk of mortality from lung cancer due to occupational exposure to respirable crystalline silica dust. METHODS: Data from a cohort mortality study of 2342 white male California diatomaceous earth mining and processing workers exposed to crystalline silica dust (mainly cristobalite) were reanalyzed with Poisson regression and Cox's proportional hazards models. Internal and external adjustments were used to control for potential confounding from the effects of time since first observation, calendar time, age, and Hispanic ethnicity. Cubic smoothing spline models were used to assess the fit of the models. Exposures were lagged by 10 years. Evaluations of the fit of the models were performed by comparing their deviances. Lifetime risks of lung cancer were estimated up to age 85 with an actuarial approach that accounted for competing causes of death. RESULTS: Exposure to respirable crystalline silica dust was a significant predictor (p<0.05) in nearly all of the models evaluated and the linear relative rate model with a 10 year exposure lag seemed to give the best fit in the Poisson regression analysis. For those who died of lung cancer the linear relative rate model predicted rate ratios for mortality from lung cancer of about 1.6 for the mean cumulative exposure to respirable silica compared with no exposure. The excess lifetime risk (to age 85) of mortality from lung cancer for white men exposed for 45 years and with a 10 year lag period at the current Occupational Safety and Health Administration (OSHA) standard of about 0.05 mg/m(3) for respirable cristobalite dust is 19/1000 (95% confidence interval (95% CI) 5/1000 to 46/1000). CONCLUSIONS: There was a significant risk of mortality from lung cancer that increased with cumulative exposure to respirable crystalline silica dust. The predicted number of deaths from lung cancer suggests that current occupational health standards may not be adequately protecting workers from the risk of lung cancer.
SN - 1351-0711
AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998. E-mail: frice@cdc.gov
U2 - PMID: 11119633.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107019894
T1 - How I do it: presenting a poster.
AU - Baker KH
Y1 - 2001///2001 Winter
N1 - Accession Number: 107019894. Language: English. Entry Date: 20010504. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9206573.
KW - Posters
KW - Public Speaking
SP - 18
EP - 19
JO - ORL-Head & Neck Nursing
JF - ORL-Head & Neck Nursing
JA - ORL HEAD NECK NURS
VL - 19
IS - 1
CY - New Smyrna Beach, Florida
PB - Society of Otorhinolaryngology & Head-Neck Nurses
SN - 1064-3842
AD - Nurse Consultant for the Ear, Nose and Throat Devices Branch, Office of Device Evaluation, Center for Devices and Radiological Health, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
AU - Kaye, Kelleen
AD - US Department of Health and Human Services
A2 - Wu, Lawrence L.
A2 - Wolfe, Barbara
T1 - Differences in Nonmarital Childbearing across States
T2 - Out of wedlock: Causes and consequences of nonmarital fertility
PB - New York:
PB - Russell Sage Foundation
Y1 - 2001///
SP - 49
EP - 76
N1 - Accession Number: 0675046; Reviewed Book ISBN: 0-87154-982-4; Keywords: Childbearing; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200402
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Fertility; Family Planning; Child Care; Children; Youth J13
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0675046&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106922310
T1 - From the Surgeon General. DHHS blueprint for action on breastfeeding.
AU - Satcher DS
Y1 - 2001/01//Jan/Feb2001
N1 - Accession Number: 106922310. Language: English. Entry Date: 20020510. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Public Health Administration
KW - Breast Feeding
KW - Health Promotion
KW - Health and Welfare Planning
KW - Health Policy
KW - United States Department of Health and Human Services -- Standards
KW - Infant
KW - Female
KW - Practice Guidelines
KW - Support, Psychosocial
KW - Attitude to Health
SP - 72
EP - 73
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 116
IS - 1
PB - Sage Publications Inc.
SN - 0033-3549
AD - US Public Health Service, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-66, Rockville, MD 20857
U2 - PMID: 11571412.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106903891
T1 - Financial disclosure by investigators in clinical research regulated by FDA.
AU - Gross MC
Y1 - 2001/01//
N1 - Accession Number: 106903891. Language: English. Entry Date: 20020301. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 100939532.
KW - Research Personnel -- Ethical Issues
KW - Truth Disclosure -- Ethical Issues
KW - Research Ethics
KW - Clinical Trials -- Economics
KW - Clinical Trials -- Ethical Issues
KW - Conflict of Interest -- Ethical Issues
KW - Education, Continuing (Credit)
KW - United States Food and Drug Administration
KW - Government Regulations
KW - Pharmaceutical Companies
KW - Bias (Research)
KW - United States
SP - 11
EP - 43
JO - Research Practitioner
JF - Research Practitioner
JA - RES PRACT
VL - 2
IS - 1
CY - Boston, Massachusetts
PB - CenterWatch
AB - Regulations require that marketing applications for drug, biologic, and device products submitted on or after 2 February 1999 include either certification that no financial arrangements identified in the rule have been made with any clinical investigator or disclosure of the specific financial arrangements. The purpose of the regulations to make FDA aware of payment arrangements between commercial sponsors and investigators that could lead to inadvertent bias in the clinical trial process. This article is an overview of the rule and of the draft guidance, which was issued on 26 October 1999.
SN - 1528-0330
AD - Office of the Commissioner, Office of International and Constituent Relations, Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MacGregor, James T.
AU - Collins, Jerry M.
AU - Sugiyama, Yuichi
AU - Tyson, Charles A.
AU - Dean, Jack
AU - Smith, Lewis
AU - Andersen, Melvin
AU - Curren, Rodger D.
AU - Houston, J. Brian
AU - Kadlubar, Fred F.
AU - Kedderis, Gregory L.
AU - Krishnan, Kannan
AU - Li, Albert P.
AU - Parchment, Ralph E.
AU - Thummel, Kenneth
AU - Tomaszewski, Joseph E.
AU - Ulrich, Roger
AU - Vickers, Alison E. M.
AU - Wrighton, Steven A.
T1 - In Vitro Human Tissue Models in Risk Assessment: Report of a Consensus-Building Workshop.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/01//
VL - 59
IS - 1
M3 - Article
SP - 17
EP - 36
PB - Oxford University Press / USA
SN - 10966080
AB - Advances in the technology of human cell and tissue culture and the increasing availability of human tissue for laboratory studies have led to the increased use of in vitro human tissue models in toxicology and pharmacodynamics studies and in quantitative modeling of metabolism, pharmacokinetic behavior, and transport. In recognition of the potential importance of such models in toxicological risk assessment, the Society of Toxicology sponsored a workshop to evaluate the current status of human cell and tissue models and to develop consensus recommendations on the use of such models to improve the scientific basis of risk assessment. This report summarizes the evaluation by invited experts and workshop attendees of the current status of such models for prediction of human metabolism and identification of drug-drug interactions, prediction of human toxicities, and quantitative modeling of pharmacokinetic and pharmaco-toxicodynamic behavior. Consensus recommendations for the application and improvement of current models are presented. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Risk assessment
KW - Cells
KW - Tissues
KW - Drugs -- Physiological effect
KW - hepatocytes
KW - human tissues
KW - in vitro cell models
KW - pharmacologically based pharmacokinetic (PBPK) modeling
KW - risk assessment
N1 - Accession Number: 44406051; MacGregor, James T. 1; Email Address: macgregorj@cder.fda.gov; Collins, Jerry M. 1; Sugiyama, Yuichi 2; Tyson, Charles A. 3; Dean, Jack 4; Smith, Lewis 5; Andersen, Melvin 6; Curren, Rodger D. 7; Houston, J. Brian 8; Kadlubar, Fred F. 9; Kedderis, Gregory L. 10; Krishnan, Kannan 11; Li, Albert P. 12; Parchment, Ralph E. 13; Thummel, Kenneth 14; Tomaszewski, Joseph E. 15; Ulrich, Roger 16; Vickers, Alison E. M. 17; Wrighton, Steven A. 18; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 2: Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; 3: SRI International, Menlo Park, California; 4: Sanofi Synthelabo, Inc., Malvern, Pennsylvania; 5: Zeneca Pharmaceuticals, Alderly Park, UK; 6: Colorado State University, Center for Environmental Toxicology and Technology, Fort Collins, Colorado; 7: Institute for in Vitro Sciences, Gaithersburg, Maryland; 8: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK; 9: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas; 10: Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina; 11: Université de Montréal, Santé Environnementale et Santé au Travail, Montréal, Québec, Canada; 12: In vitro Technologies, Inc., Baltimore, Maryland; 13: Karmanos Cancer Institute, Wayne State University, Detroit, Michigan; 14: University of Washington, Department of Pharmaceutics, Seattle, Washington; 15: National Cancer Institute, Toxicology and Pharmacology Branch, Rockville, Maryland; 16: Abbott Laboratories, Abbott Park, Illinois; 17: Novartis Institute for Biomedical Research, Department of Preclinical Safety, East Hanover, New Jersey; 18: Eli Lilly & Company, Indianapolis, Indiana; Issue Info: Jan2001, Vol. 59 Issue 1, p17; Thesaurus Term: Toxicology; Thesaurus Term: Risk assessment; Subject Term: Cells; Subject Term: Tissues; Subject Term: Drugs -- Physiological effect; Author-Supplied Keyword: hepatocytes; Author-Supplied Keyword: human tissues; Author-Supplied Keyword: in vitro cell models; Author-Supplied Keyword: pharmacologically based pharmacokinetic (PBPK) modeling; Author-Supplied Keyword: risk assessment; Number of Pages: 20p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huang, Shu-Hai
AU - Hubbs, Ann F.
AU - Stanley, Charles F.
AU - Vallyathan, Val
AU - Schnabel, Peter C.
AU - Rojanasakul, Yongyut
AU - Ma, Joseph K. H.
AU - Banks, Daniel E.
AU - Weissman, David N.
T1 - Immunoglobulin Responses to Experimental Silicosis.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/01//
VL - 59
IS - 1
M3 - Article
SP - 108
EP - 117
PB - Oxford University Press / USA
SN - 10966080
AB - Silicosis is a crippling fibrotic lung disease induced by inhalation of crystalline silica. One feature of silicosis is systemic and pulmonary immune dysfunction characterized in part by elevations in serum and bronchoalveolar lavage (BAL) immunoglobulins. A major specific aim of the current report was to demonstrate that an experimental model of silicosis previously well characterized for the development of pulmonary inflammation and fibrosis would also exhibit increased levels of serum and BAL IgG and IgM similar to those of human silicosis. We also sought to document the anatomic compartments responsible for these immunoglobulin responses. To address these specific aims, we compared levels of IgG and IgM in serum and BAL from rats with experimental silicosis induced by inhalation of silica with levels of these immunoglobulins in titanium dioxide (TiO2)- and sham (air)-exposed controls. The ability of mononuclear cell populations from lung, lung-associated lymph node, and spleen to produce IgG and IgM ex vivo were also compared. We found that experimental silicosis was associated with elevated IgG and IgM levels in blood and BAL relative to the control groups. Our findings also suggested that draining lung-associated lymph nodes (LALN) were the most important sites for increased IgG and IgM production in experimental silicosis, with lungs contributing to a lesser degree. Increased production in the LALN appeared related to marked expansion in total numbers, but not relative proportion, of B lymphocytes. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silicosis
KW - Lung diseases
KW - Fibrosis
KW - Serum
KW - Bronchoalveolar lavage
KW - Immunoglobulins
KW - B cells
KW - bronchoalveolar lavage
KW - IgG
KW - IgM
KW - lymphocyte
KW - quartz
KW - rat
KW - silicosis
KW - titanium dioxide
N1 - Accession Number: 44406057; Huang, Shu-Hai 1; Hubbs, Ann F. 2; Stanley, Charles F. 1; Vallyathan, Val 2; Schnabel, Peter C. 1; Rojanasakul, Yongyut 1; Ma, Joseph K. H. 1; Banks, Daniel E. 1; Weissman, David N. 2; Email Address: dqw4@cdc.gov; Affiliations: 1: West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Analytical Services Branch, 1095 Willowdale Road, Morgantown, West Virginia 26505; Issue Info: Jan2001, Vol. 59 Issue 1, p108; Subject Term: Silicosis; Subject Term: Lung diseases; Subject Term: Fibrosis; Subject Term: Serum; Subject Term: Bronchoalveolar lavage; Subject Term: Immunoglobulins; Subject Term: B cells; Author-Supplied Keyword: bronchoalveolar lavage; Author-Supplied Keyword: IgG; Author-Supplied Keyword: IgM; Author-Supplied Keyword: lymphocyte; Author-Supplied Keyword: quartz; Author-Supplied Keyword: rat; Author-Supplied Keyword: silicosis; Author-Supplied Keyword: titanium dioxide; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rier, Sherry E.
AU - Turner, Wayman E.
AU - Martin, Dan C.
AU - Morris, Richard
AU - Lucier, George W.
AU - Clark, George C.
T1 - Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/01//
VL - 59
IS - 1
M3 - Article
SP - 147
EP - 159
PB - Oxford University Press / USA
SN - 10966080
AB - Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with a dose-dependent increase in the incidence and severity of endometriosis in the rhesus monkey. Dioxin-like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor. This study demonstrates that the serum levels of TCDD and specific dioxin-like PHAH congeners were increased in TCDD-treated animals with endometriosis 13 years after the TCDD exposure. Nine TCDD-exposed and 6 unexposed female rhesus monkeys were evaluated for serum content of relevant compounds and for endometriosis by surgical laparoscopy. Additional studies were done on 4 animals that died 7 to 11 years after exposure to TCDD and 4 lead-treated animals with no history of PHAH treatment. For TCDD-exposed and unexposed animals, TCDD exposure correlated with an increased serum TCDD concentration. Furthermore, TCDD exposure and an elevated serum TCDD concentration were associated with increased serum levels of triglycerides, 1,2,3,6,7,8-hexachlorodibenzofuran, 3,3′,4,4′-tetrachlorobiphenyl (TCB) and 3,3′4,4′,5-pentachlorobiphenyl (PnCB). Importantly, the animals with elevated serum levels of 3,3′,4,4′-TCB, 3,3′,4,4′,5-PnCB and an increased total serum TEQ had a high prevalence of endometriosis, and the severity of disease correlated with the serum concentration of 3,3,',4,4′-TCB. Increased serum concentrations of coplanar PCBs were also present in lead-treated animals. Implications of these findings for human health and the prevalence of endometriosis in humans will be discussed. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hydrocarbons
KW - Tetrachlorodibenzodioxin
KW - Environmental toxicology
KW - Dioxins
KW - Endometriosis
KW - Rhesus monkey
KW - Laparoscopy
KW - Chemicals
KW - dioxin
KW - dioxin-like chemicals
KW - endometriosis
KW - environmental toxicants
KW - PCB
KW - rhesus monkey
KW - TCDD
N1 - Accession Number: 44406068; Rier, Sherry E. 1; Email Address: sherry.rier@mcmail.vanderbilt.edu; Turner, Wayman E. 2; Martin, Dan C. 3; Morris, Richard 4; Lucier, George W. 4; Clark, George C. 4; Affiliations: 1: Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756; 2: Centers for Disease Control, U.S. Public Health Service, Atlanta, Georgia 30341; 3: Department of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee 38103; 4: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709; Issue Info: Jan2001, Vol. 59 Issue 1, p147; Thesaurus Term: Hydrocarbons; Thesaurus Term: Tetrachlorodibenzodioxin; Thesaurus Term: Environmental toxicology; Thesaurus Term: Dioxins; Subject Term: Endometriosis; Subject Term: Rhesus monkey; Subject Term: Laparoscopy; Subject Term: Chemicals; Author-Supplied Keyword: dioxin; Author-Supplied Keyword: dioxin-like chemicals; Author-Supplied Keyword: endometriosis; Author-Supplied Keyword: environmental toxicants; Author-Supplied Keyword: PCB; Author-Supplied Keyword: rhesus monkey; Author-Supplied Keyword: TCDD; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 13p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107065788
T1 - 100% access and 0 health disparities: changing the health paradigm for rural women in the 21st century...Bridging Rural Women's Health into the New Millennium
AU - Gaston MH
Y1 - 2001/01//2001 Jan-Feb
N1 - Accession Number: 107065788. Language: English. Entry Date: 20011109. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Women's Health
KW - Rural Health
KW - Rural Health Services
KW - Health Services Accessibility
KW - United States
KW - Maternal-Child Health
KW - Health Status
KW - Female
SP - 7
EP - 16
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 11
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Associate Administrator for Primary Health Care, Health Resources and Services Administration, Bureau of Primary Health Care HRSA, US Dept of Health & Human Services, Bethesda, MD
U2 - PMID: 11166592.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107065788&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2001-03415-001
AN - 2001-03415-001
AU - Randall, Leslie L.
AU - Krogh, Christopher
AU - Welty, Thomas K.
AU - Willinger, Marian
AU - Iyasu, Solomon
T1 - The Aberdeen Indian Health Service Infant Mortality Study: Design, methodology, and implementation.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 2001///
VL - 10
IS - 1
SP - 1
EP - 20
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
AD - Randall, Leslie L., 5300 Homestead Rd., NE, Albuquerque, NM, US, 87110
N1 - Accession Number: 2001-03415-001. PMID: 11484150 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Randall, Leslie L.; Indian Health Service Headquarters West, National Programs, Albuquerque, NM, US. Release Date: 20011010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Etiology; Experimental Design; Models; Mortality Rate. Minor Descriptor: Death and Dying. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Methodology: Empirical Study; Longitudinal Study; Prospective Study. References Available: Y. Page Count: 20. Issue Publication Date: 2001.
AB - Of all Indian Health Service areas, the Aberdeen Area has consistently had the highest infant mortality rate. Among some tribes in this area the rate has exceeded 30/1000 live birth and half the infant deaths have been attributed to Sudden Infant Death Syndrome, a rate 4 to 5 times higher than the national average. Multiple organizations collaborated to investigate these high rates with the goals of refining the ascertainment of the causes of death, improving cause-specific infant mortality rates and identifying factors contributing to the high rates. 10 of the 19 tribes or tribal communities, representing 66% of the area population, participated in a 4-yr prospective case-control study of infants who died after discharge from the hospital. From December 1, 1992 until November 30, 1996, 72 infant deaths were investigated. This report describes the study methods and the model employed for involving the community and multiple agencies to study the problem of infant mortality among Northern Plains Indians. Data gathered during the investigations are being analyzed and will be published at a later date. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Northern Plains American Indians
KW - infant mortality
KW - epidemiology
KW - experimental design
KW - methodology
KW - models
KW - death and dying
KW - 2001
KW - American Indians
KW - Etiology
KW - Experimental Design
KW - Models
KW - Mortality Rate
KW - Death and Dying
KW - 2001
DO - 10.5820/aian.1001.2001.1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-03415-001&site=ehost-live&scope=site
UR - Leslie.Randall@mail.his.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-03764-005
AN - 2011-03764-005
AU - Weir, Jerry P.
T1 - Infection of human NT2 cells and differentiated NT-neurons with herpes simplex virus and replication-incompetent herpes simplex virus vectors.
JF - Journal of Neurovirology
JO - Journal of Neurovirology
JA - J Neurovirol
Y1 - 2001/01//
VL - 7
IS - 1
SP - 43
EP - 51
CY - United Kingdom
PB - Taylor & Francis
SN - 1355-0284
SN - 1538-2443
AD - Weir, Jerry P., Division of Viral Products, HEM-457, Center for Biologics Evaluation and Research, 1401 Rock ville Pike, Rock ville, MD, US, 20852
N1 - Accession Number: 2011-03764-005. PMID: 11519481 Partial author list: First Author & Affiliation: Weir, Jerry P.; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, US. Other Publishers: Informa Healthcare; Springer. Release Date: 20110704. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Herpes Simplex; Infectious Disorders; Neurons. Minor Descriptor: Genes. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2001. Publication History: Accepted Date: Sep 14, 2000; Revised Date: Aug 17, 2000; First Submitted Date: May 30, 2000. Copyright Statement: Taylor & Francis Ltd. 2001.
AB - The human embryonal carcinoma cell line NT2 differentiates irreversibly into postmitotic neuron-like cells following treatment with retinoic acid. These differentiated NT-neurons resemble central nervous system(CNS) neurons and are characterized by development of dendrites and axons and the expression of neuron-specific markers. Because of their unique biological characteristics, NT-neurons were investigated for their utility as a system for studying the replication of herpes simplex virus (HSV) in the neuron and for evaluating characteristics of HSV vectors designed for gene delivery to the neuron. Virus replication in differentiated NT-neurons was significantly reduced and delayed relative to replication in undifferentiated NT2 cells. Replication of thymidine-kinase (tk) deficient HSV was further impaired in NT-neurons, reflecting the behavior of tk-negative virus in primary neurons in vitro and ganglia in vivo. Furthermore, replication-incompetent HSV vectors were capable of infecting NT-neurons, expressing a foreign gene, and persisting in a recoverable state for at least 2 weeks following delivery.These results suggest that differentiated NT-neurons can provide a continuous source of human, post-mitotic neurons-like cells for the study of HSV biology and HSV vector development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - herpes simplex virus infection
KW - neurons
KW - herpes simplex virus vectors
KW - genes
KW - 2001
KW - Herpes Simplex
KW - Infectious Disorders
KW - Neurons
KW - Genes
KW - 2001
DO - 10.1080/135502801300069656
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-03764-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-09568-006
AN - 2001-09568-006
AU - MacNeil Horton, Arthur Jr.
AU - Roberts, Charles
T1 - Demographic effects on the Trail Making Test in narcotic/other opiate abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001///
VL - 111
IS - 1-2
SP - 101
EP - 107
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - MacNeil Horton, Arthur Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, 5600 Fishers Lane, Suite 840, Rockville, MD, US, 20857
N1 - Accession Number: 2001-09568-006. Partial author list: First Author & Affiliation: MacNeil Horton, Arthur Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020313. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Educational Attainment Level; Human Sex Differences; Neuropsychological Assessment; Racial and Ethnic Differences. Minor Descriptor: Drug Abuse; Drug Rehabilitation. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: 2001.
AB - Examined the effects of demographic characteristics on scores attained on the Trail Making Test (R. M. Reitan, 1955, TMT) by narcotic and other opiate abusers in drug abuse treatment programs. 191 drug rehabilitation attendees (aged 18–44+ yrs) completed both Parts A and B of the TMT. Examined variables included gender, ethnicity, age, and education. Results show that age and education level were significantly related to TMT Parts A and B, and ethnicity was statistically significant for Part B of the TMT. It is concluded that demographic effects on the TMT are moderate. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Trail Making Test
KW - narcotics abuse
KW - opiate abuse
KW - drug rehabilitation
KW - gender differences
KW - ethnic differences
KW - age differences
KW - educational attainment level
KW - 2001
KW - Age Differences
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Neuropsychological Assessment
KW - Racial and Ethnic Differences
KW - Drug Abuse
KW - Drug Rehabilitation
KW - 2001
DO - 10.3109/00207450108986555
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09568-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-09568-008
AN - 2001-09568-008
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Derived Trail Making Test indices in a sample of substance abusers: Demographic effects.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001///
VL - 111
IS - 1-2
SP - 123
EP - 132
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, 5600 Fishers Lane, Suite 840, Rockville, MD, US, 20857
N1 - Accession Number: 2001-09568-008. PMID: 11913334 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020313. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Educational Attainment Level; Human Sex Differences; Neuropsychological Assessment; Racial and Ethnic Differences. Minor Descriptor: Age Differences; Drug Abuse; Drug Rehabilitation; Test Interpretation. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: 2001.
AB - Derived indices on the Trail Making Test (TMT), a test often used to screen for cognitive impairments, were examined in a sample of substance abusers in drug abuse treatment programs. A mixed race sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991 through 1993 within 96 programs in 11 cities in the US. Data were analyzed to determine the effects of demographic variables on derived indices created by adding, subtracting, multiplying, and dividing parts A and B of the TMT in this large treatment sample of substance abusers. The variables of sex, age, ethnicity, and education were statistically significant for selected derived indices of the TMT. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Trail Making Test
KW - drug abuse
KW - drug rehabilitation
KW - gender differences
KW - ethnic differences
KW - age differences
KW - educational attainment level
KW - test interpretation
KW - demographics
KW - 2001
KW - Demographic Characteristics
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Neuropsychological Assessment
KW - Racial and Ethnic Differences
KW - Age Differences
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Test Interpretation
KW - 2001
DO - 10.3109/00207450108986557
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09568-008&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-14291-002
AN - 2001-14291-002
AU - Badia, Xavier
AU - Herdman, Michael
T1 - The importance of health-related quality-of-life data in determining the value of drug therapy.
JF - Clinical Therapeutics: The International Peer-Reviewed Journal of Drug Therapy
JO - Clinical Therapeutics: The International Peer-Reviewed Journal of Drug Therapy
JA - Clin Ther
Y1 - 2001/01//
VL - 23
IS - 1
SP - 168
EP - 175
CY - Netherlands
PB - Elsevier Science
SN - 0149-2918
N1 - Accession Number: 2001-14291-002. PMID: 11219476 Partial author list: First Author & Affiliation: Badia, Xavier; Hospital de Santa Creu, Clinical Epidemiology & Public Health Service, Health Care Outcomes Research Unit, Barcelona, Spain. Release Date: 20010411. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Quality of Life; Treatment Effectiveness Evaluation. Classification: Clinical Psychopharmacology (3340). References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2001.
AB - Discusses the factors that affect the relative importance of health-related quality of life (HRQOL) data in determining the value of drug therapy. It is argued that the relative importance of HRQOL data depends on the type of condition and the type of treatment. In chronic conditions, HRQOL may be considered a primary measure of efficacy. In acute conditions, HRQOL is not likely to be a primary efficacy measure, although excluding HRQOL measures may lead to an underestimation of treatment effects. Measures of HRQOL are also likely to be important in the assessment of palliative treatments and, to some extent, preventive treatments (primarily in the measurement of adverse effects). HRQOL measures will be less important in the assessment of curative treatments because these types of treatment are most relevant in acute conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - factors affecting the importance of health related quality of life data in determining value of drug therapy
KW - 2001
KW - Drug Therapy
KW - Quality of Life
KW - Treatment Effectiveness Evaluation
KW - 2001
DO - 10.1016/S0149-2918(01)80039-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-14291-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107011853
T1 - On-demand use of ß2-agonists led to better asthma control than did regular use in moderate-to-severe asthma...commentary on Richter B, Bender R, Berger M. Effects of on-demand ß2-agonist inhalation in moderate-to-severe asthma. A randomized controlled trial. J INTERN MED 2000 Jun;247:657-66
AU - Honig PK
Y1 - 2001/01/02/
N1 - Accession Number: 107011853. Language: English. Entry Date: 20010406. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Asthma -- Drug Therapy
KW - Adrenergic Beta-Agonists -- Administration and Dosage
KW - Administration, Inhalation
KW - Clinical Trials
KW - Prospective Studies
KW - Crossover Design
KW - Random Assignment
KW - Adrenal Cortex Hormones -- Therapeutic Use
KW - Albuterol -- Therapeutic Use
KW - Treatment Outcomes
KW - Respiratory Function Tests
KW - P-Value
KW - Female
KW - Male
KW - Middle Age
KW - Outpatients
KW - Outpatient Service
KW - Germany
SP - 17
EP - 17
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 134
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Food and Drug Administration, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106910918
T1 - A national treatment plan to improve substance abuse treatment: addictions health policy in action.
AU - Barry CT
Y1 - 2001/01/02/
N1 - Accession Number: 106910918. Language: English. Entry Date: 20020329. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9616159.
KW - Substance Use Rehabilitation Programs
KW - Health Policy
KW - Substance Abuse -- Organizations
KW - Substance Abuse -- Prevention and Control
KW - Health and Welfare Planning
KW - United States
SP - 75
EP - 82
JO - Journal of Addictions Nursing (Taylor & Francis Ltd)
JF - Journal of Addictions Nursing (Taylor & Francis Ltd)
JA - J ADDICT NURS (TAYLOR & FRANCIS LTD)
VL - 13
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1088-4602
AD - Center for Mental Health Services, US Department of Health and Human Services, Rockville, Maryland
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106910918&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Weindruch, Richard
AU - Keenan, Kevin P.
AU - Carney, John M.
AU - Fernandes, Gabriel
AU - Feuers, Ritchie J.
AU - Floyd, Robert A.
AU - Halter, Jeffrey B.
AU - Ramsey, Jon J.
AU - Richardson, Arlan
AU - Roth, George S.
AU - Spindler, Stephen R.
T1 - Caloric Restriction Mimetics.
JO - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Y1 - 2001/01/02/
VL - 56
IS - suppl_1
M3 - Article
SP - 20
EP - 33
SN - 10795006
AB - Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being tested in nonhuman primates. One way to apply these findings to human health is to identify and test agents that may mimic critical actions of CR. Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics exist. It was recommended that studies on oxidative stress should emphasize mitochondrial function and to test the efficacy of nitrone and other antioxidants in mimicking CR's effects. Studies should also focus on the long-term effects of compounds known to lower circulating glucose and insulin concentrations or to increase insulin sensitivity. Also, four other developing areas were identified: intermediary metabolism, response to infection, stress responses, and source of dietary fat. These areas are important because either they hold promise for the discovery of new mimetics or they need to be explored prior to initiation of CR trials in humans. Other recommendations were that transgenic approaches and adult-onset CR should be emphasized in future studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journals of Gerontology Series A: Biological Sciences & Medical Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - RODENTS as laboratory animals
KW - GLUCOSE -- Physiological effect
KW - OXIDATIVE stress
KW - INSULIN resistance
N1 - Accession Number: 80090448; Weindruch, Richard 1,2,3,4,5,6,7,8,9,10,11; Keenan, Kevin P. 1,2,3,4,5,6,7,8,9,10,11; Carney, John M. 1,2,3,4,5,6,7,8,9,10,11; Fernandes, Gabriel 1,2,3,4,5,6,7,8,9,10,11; Feuers, Ritchie J. 1,2,3,4,5,6,7,8,9,10,11; Floyd, Robert A. 1,2,3,4,5,6,7,8,9,10,11; Halter, Jeffrey B. 1,2,3,4,5,6,7,8,9,10,11; Ramsey, Jon J. 1,2,3,4,5,6,7,8,9,10,11; Richardson, Arlan 1,2,3,4,5,6,7,8,9,10,11; Roth, George S. 1,2,3,4,5,6,7,8,9,10,11; Spindler, Stephen R. 1,2,3,4,5,6,7,8,9,10,11; Source Information: 2001, Vol. 56 Issue suppl_1, p20; Subject: LOW-calorie diet; Subject: RODENTS as laboratory animals; Subject: GLUCOSE -- Physiological effect; Subject: OXIDATIVE stress; Subject: INSULIN resistance; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Poehlman, Eric T.
AU - Turturro, Angelo
AU - Bodkin, Noni
AU - Cefalu, William
AU - Heymsfield, Steve
AU - Holloszy, John
AU - Kemnitz, Joseph
T1 - Caloric Restriction Mimetics.
JO - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Y1 - 2001/01/02/
VL - 56
IS - suppl_1
M3 - Article
SP - 45
EP - 54
SN - 10795006
AB - As the only paradigm that has consistently increased life span and inhibited the onset and/or progression of disease, dietary restriction has multiple effects on a variety of organ systems. In this brief review, the goal of the panel was to attempt to understand the role of changes in physical activity and body composition as possible modulators of the life span in experimental animals and humans. We focus on whether changes in exercise behavior and body composition produce similar changes as those found in dietary restriction and whether these changes can be used to either replace or enhance the beneficial effects of dietary restriction. The complexity of the two stimuli is emphasized in our report, with suggestions offered on how to better interpret existing research. Our panel briefly examines evidence in experimental animals and humans about the specific contributions of each of these factors to altering life span and age-related pathologies. We also discuss additional animal studies and/or human intervention studies that could be performed to clarify these issues. Finally, we provide suggested avenues for future research in this area of changes in physical activity and body composition as dietary restriction mimetics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journals of Gerontology Series A: Biological Sciences & Medical Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet -- Physiological aspects
KW - LIFE spans (Biology)
KW - DISEASE progression
KW - HUMAN body composition
KW - PATHOLOGY
N1 - Accession Number: 80090450; Poehlman, Eric T. 1,2,3,4,5,6; Turturro, Angelo 1,2,3,4,5,6; Bodkin, Noni 1,2,3,4,5,6; Cefalu, William 1,2,3,4,5,6; Heymsfield, Steve 1,2,3,4,5,6; Holloszy, John 1,2,3,4,5,6; Kemnitz, Joseph 1,2,3,4,5,6; Source Information: 2001, Vol. 56 Issue suppl_1, p45; Subject: LOW-calorie diet -- Physiological aspects; Subject: LIFE spans (Biology); Subject: DISEASE progression; Subject: HUMAN body composition; Subject: PATHOLOGY; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107019881
T1 - Energy for a new millennium -- regulatory perspectives...Defining energy for a new millennium, Washington, DC, April 4-5, 2000
AU - Yetley EA
Y1 - 2001/01/02/Jan2001 Part 2
N1 - Accession Number: 107019881. Language: English. Entry Date: 20010504. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Dietary Supplementation -- Legislation and Jurisprudence
KW - Energy Intake
KW - Food Labeling -- Legislation and Jurisprudence
KW - Anemia, Iron Deficiency
KW - Food
KW - Nutrition
SP - S33
EP - 4
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 59
IS - 1
PB - Oxford University Press / USA
SN - 0029-6643
AD - Lead Scientist, Nutrition, Center for Food Safety and Applied Nutrition, Food & Drug Administration, Washington, DC 20204
U2 - PMID: 11255803.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mcclain, R. Michael
AU - Keller, Douglas
AU - Casciano, Dan
AU - Fu, Peter
AU - Macdonald, James
AU - Popp, James
AU - Sagartz, John
T1 - Neonatal Mouse Model: Review of Methods and Results.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2001/01/02/Jan2001 Supplement
VL - 29
IS - 1S
M3 - Article
SP - 128
EP - 137
SN - 01926233
AB - The neonatal mouse model, in various forms, has been used experimentally since 1959 and a large number of chemicals have been tested. The neonatal model is known to be very sensitive for the detection of carcinogens that operate via a genotoxic mode of action. In contrast, it is known not to respond to chemicals that act via epigenetic mechanisms, commonly observed in the two-year carcinogenicity studies. As such, the model has a high sensitivity and specifi city in its response. Dose selection for the neonatal model is based on the maximum tolerated or feasible dose. Traditionally, compounds have been tested via the IP route of administration in this model. In some cases, this has limited the amount of material that can be administered because of the low dosing volumes (10 to 20 μL) that can be administered IP. For the ILSI project, the neonatal model was adapted for oral administration, which has the advantages of being the same route for which most pharmaceuticals are administered. In addition, a 10-fold increase in the volume of administration (100 to 200 μL) and the ability to dose drugs in suspension, permits much higher doses to be used as compared to the IP route of administration. The spontaneous tumors in the neonatal model occurred mainly in the liver of male mice and lung of male and female mice with a few tumors observed in the Harderian gland. The positive control, DEN produced a robust, uniform, and reproducible tumor response with the target organs essentially limited to liver and lung. A total of 13 compounds out of the 21 ILSI ACT compounds were evaluated in the neonatal model involving 18 studies with duplicate studies for some compounds. The genotoxic carcinogens including those used as positive controls were clearly positive (cyclophosphamide, diethylnitrosamine, 6-nitrochrysene). The non-genotoxicrodent carcinogens were clearly negative (chlorpromazine, sulfi soxazole, sulfamethoxazole, clofi brate, DEHP, haloperidol, metaproteranol, and phenobarbital). The non-genotoxic human carcinogen (cyclosporin) was clearly negative. The two other human carcinogens phenacetin and DES were negative and interestingly estradiol was negative in one of the two oral studies, but was clearly positive in the other. Considering the mode of action for three of the human carcinogens (DES, cyclosporin and phenacetin), which were negative in this model, the mode of action in humans is likely to be epigenetic. Overall, for the 3 clearly genotoxic chemicals, all were positive. For the 9 clearly non-genotoxic chemicals, all 9 were negative. The two human carcinogens for which genotoxicity may or may not play a role (DES and phenacetin) were negative and estradiol was positive in 1 of the two oral studies. Overall, the extensive database for compounds tested in the neonatal mouse model would support its use as an alternative model for the assessment of the carcinogenic potential of a chemical. The model responds to chemicals that act via a genotoxic mode of action that represent a greater concern for human cancer risk. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - 52-weeks
KW - alternatives
KW - bioassay
KW - carcinogenicity
KW - Neonatal mouse
KW - short-term
KW - testing
N1 - Accession Number: 54381053; Mcclain, R. Michael 1; Keller, Douglas 2; Casciano, Dan 2; Fu, Peter 2; Macdonald, James 2; Popp, James 2; Sagartz, John 2; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Sanofi-Synthelabo Research, Schering-Plough Research Institute, DuPont Pharmaceuticals Company, Monsanto Life Sciences, michaelmcclain@msn.com; 2: National Center for Toxicological Research, Food and Drug Administration, Sanofi-Synthelabo Research, Schering-Plough Research Institute, DuPont Pharmaceuticals Company, Monsanto Life Sciences; Issue Info: Jan2001 Supplement, Vol. 29 Issue 1S, p128; Author-Supplied Keyword: 52-weeks; Author-Supplied Keyword: alternatives; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: Neonatal mouse; Author-Supplied Keyword: short-term; Author-Supplied Keyword: testing; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6732
L3 - 10.1080/019262301753178537
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
ID - 89368257
T1 - Conflicting phase II efficacy data for Doxil.
AU - Frykman, Gregory
AU - Williams, Grant
AU - Pazdur, Richard
AU - Gordon, Alan N.
AU - Frykman, G
AU - Williams, G
AU - Pazdur, R
Y1 - 2001/01/15/
N1 - Accession Number: 89368257. Language: English. Entry Date: 20010525. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Ovarian Neoplasms -- Drug Therapy
KW - Antineoplastic Agents -- Therapeutic Use
KW - Doxorubicin -- Therapeutic Use
KW - Clinical Trials
KW - United States
KW - United States Food and Drug Administration
KW - Female
KW - Drug Approval
SP - 596
EP - 597
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 2
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, MD
AD - Texas Oncology, Dallas, TX
U2 - PMID: 11208859.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - London, A. S.
AU - Fleishman, J. A.
AU - Goldman, D. P.
AU - McCaffrey, D. F.
AU - Bozzette, S. A.
AU - Shapiro, M. F.
AU - Leibowitz, A. A.
T1 - Use of unpaid and paid home care services among people with HIV infection in the USA.
JO - AIDS Care
JF - AIDS Care
Y1 - 2001/02//
VL - 13
IS - 1
M3 - Article
SP - 99
EP - 121
PB - Routledge
SN - 09540121
AB - This paper examines utilization of paid and unpaid home health care using data from a nationally representative sample of HIV-positive persons receiving medical care in early 1996 (N = 2,864). Overall, 21.0% used any home care, 12.2% used paid care and 13.6% used unpaid care. Most (70.0%) users of home care received care from only one type of provider. Substantially more hours of unpaid than paid care were used. We also found evidence of a strong association between type of service used and type of care provider: 62.4% of persons who used nursing services only received paid care only; conversely, 55.5% of persons who used personal care services only received care only from unpaid caregivers. Use of home care overall was concentrated among persons with AIDS: 39.5% of persons with AIDS received any home health care, compared to 9.5% of those at earlier disease stages. In addition to having an AIDS diagnosis, logistic regression analyses indicated that other need variables significantly increased utilization; a higher number of HIV-related symptoms, lower physical functioning, less energy, a diagnosis of CMV and a recent hospitalization each independently increased the odds of overall home care utilization. Sociodemographic variables had generally weak relationships with overall home care utilization. Among users of home care, non-need variables had more influence on use of paid than unpaid care. Both paid and unpaid home health care is a key component of community-based systems of care for people with HIV infection. The results presented in this paper are the first nationally representative estimates of home care utilization by persons with HIV/AIDS and are discussed with reference to policy and future research. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - MEDICAL care -- United States
KW - HOME care services
KW - UNITED States
N1 - Accession Number: 3998534; London, A. S. 1; Fleishman, J. A. 2; Goldman, D. P. 3; McCaffrey, D. F. 3; Bozzette, S. A. 4; Shapiro, M. F. 5; Leibowitz, A. A. 6; Source Information: Feb2001, Vol. 13 Issue 1, p99; Subject: HIV-positive persons; Subject: MEDICAL care -- United States; Subject: HOME care services; Geographic Terms: UNITED States; Number of Pages: 23p; Illustrations: 8 Charts; Document Type: Article; Full Text Word Count: 12724
L3 - 10.1080/09540120020018215
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Satcher, David
T1 - Why We Need an International Agreement on Tobacco Control.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/02//
VL - 91
IS - 2
M3 - Editorial
SP - 191
EP - 193
PB - American Public Health Association
SN - 00900036
AB - This article addresses the need for an international agreement on tobacco control. The percentage of deaths worldwide that is attributable to tobacco use is projected to increase from 6 percent in 1990 to 12.3 percent in 2020. Cigarette smuggling provides consumers with products at below-market prices, making the action a public health problem as well as a law enforcement problem. Tobacco manufacturers adapt their advertising practices for developing countries, often across borders. Data and data analysis are important tools in communicating the nature and scope of the tobacco problem to policymakers and the public and in monitoring progress in controlling use of tobacco.
KW - Public health
KW - Tobacco -- Law & legislation
KW - Treaties
KW - Mortality -- Statistics
KW - Smuggling
KW - Law enforcement
KW - Advertising -- Tobacco
KW - Developing countries
N1 - Accession Number: 4034923; Satcher, David 1; Affiliations: 1: Surgeon General and Assistant Secretary for Health, US Public Health Service, US Department of Health and Human Services; Issue Info: Feb2001, Vol. 91 Issue 2, p191; Thesaurus Term: Public health; Subject Term: Tobacco -- Law & legislation; Subject Term: Treaties; Subject Term: Mortality -- Statistics; Subject Term: Smuggling; Subject Term: Law enforcement; Subject Term: Advertising -- Tobacco; Subject Term: Developing countries; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Rust, George
AU - Curtin, Thomas
AU - Gaston, Marilyn Hughes
AU - Vinicor, Frank
AU - Chin, Marshall H.
AU - Auerbach, Steven B.
AU - Cook, Sandy
AU - Harrison, James
AU - Koppert, Julie
AU - Lei Jin
AU - Thiel, Fay
AU - Karrison, Theodore G.
AU - Harrand, Anita
AU - Schaefer, Cynthia T.
AU - Takashima, Herbert T.
AU - Egbert, Nancy
AU - Sin-Ching Chiu
AU - McNabb, Wylie
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/02//
VL - 91
IS - 2
M3 - Letter
SP - 318
EP - 320
PB - American Public Health Association
SN - 00900036
AB - Two letters to the editor are presented in response to the article "Quality of Diabetes Care in Community Health Centers," by M. H. Chin and others in the 2000 issue.
KW - Public health
KW - Letters to the editor
KW - Diabetes
KW - Medical care -- Quality control
KW - Community health services
N1 - Accession Number: 4035102; Rust, George 1; Email Address: rustg@msm.edu; Curtin, Thomas 2; Gaston, Marilyn Hughes 3; Email Address: mgastom@hrsa.gov; Vinicor, Frank 4; Chin, Marshall H. 5,6; Email Address: mchin@medicine.bsd.uchicago.edu; Auerbach, Steven B. 7; Cook, Sandy 5,6; Harrison, James 8; Koppert, Julie 9; Lei Jin 5,6; Thiel, Fay 10; Karrison, Theodore G. 5,6; Harrand, Anita 11; Schaefer, Cynthia T. 12; Takashima, Herbert T. 13; Egbert, Nancy 14; Sin-Ching Chiu 15; McNabb, Wylie 5,6; Affiliations: 1: National Center for Primary Care, Morehouse School of Medicine, Atlanta, Ga.; 2: National Association of Community Health Centers, Washington, DC; 3: Bureau of Primary Health Care, Health Resources and Services Administration, Bethesda, Md.; 4: Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Ga.; 5: Department of Medicine, Diabetes Research and Training Center, University of Chicago, Chicago, Ill.; 6: Department of Health Studies, Diabetes Research and Training Center, University of Chicago, Chicago, Ill.; 7: Health Resources and Services Administration, New York, NY; 8: North Woods Community Health Center, Minong, Wis.; 9: MidWest Clinicians' Network, Inc., Kenton, Ohio; 10: MidWest Clinicians' Network, Inc., Okomos, Mich.; 11: Hamilton Family Medical Center, Flint, Mich.; 12: ECHO Health Center, Louisville, Ind.; 13: Health Resources and Services Administration, Kansas City, Mo.; 14: Health Resources and Services Administration, Chicago, Ill.; 15: Family Medical Center, Temperance, Mich.; Issue Info: Feb2001, Vol. 91 Issue 2, p318; Thesaurus Term: Public health; Subject Term: Letters to the editor; Subject Term: Diabetes; Subject Term: Medical care -- Quality control; Subject Term: Community health services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107063773
T1 - The epidemiology of hospitalization of elderly Americans for septicemia or bacteremia in 1991-1998: application of Medicare claims data.
AU - Baine WB
AU - Yu W
AU - Summe JP
Y1 - 2001/02//2001 Feb
N1 - Accession Number: 107063773. Language: English. Entry Date: 20011026. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013.
KW - Sepsis -- Epidemiology -- In Old Age
KW - Hospitalization -- Economics -- In Old Age
KW - Medicare
KW - Gerontologic Care
KW - Sepsis -- Economics -- In Old Age
KW - Epidemiological Research
KW - Surveys
KW - Record Review
KW - Costs and Cost Analysis
KW - Mortality
KW - Pearson's Correlation Coefficient
KW - P-Value
KW - Descriptive Statistics
KW - Incidence
KW - Descriptive Research
KW - Bacteremia -- Epidemiology -- In Old Age
KW - Health Facility Costs
KW - United States Centers for Medicare and Medicaid Services
KW - Sepsis -- Trends -- In Old Age
KW - Escherichia Coli Infections -- In Old Age
KW - Staphylococcal Infections -- In Old Age
KW - Sex Factors
KW - Race Factors
KW - Length of Stay
KW - Aged
KW - Aged, 80 and Over
KW - Inpatients
KW - Male
KW - Female
KW - Human
SP - 118
EP - 126
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 11
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: To describe the epidemiology of hospitalization of elderly Americans for septicemia or bacteremia. METHODS: Medicare claims data for discharges from 1991 through 1998 were used to study 75,920 hospitalizations with the principal diagnosis of septicemia or bacteremia in patients aged 65 years or older. RESULTS: 'Unspecified septicemia' was the commonest principal diagnosis, followed by septicemia due to Escherichia coli or staphylococci. From 1991 through 1997, annual discharges for 'unspecified septicemia' increased 108%, and those for pneumococcal septicemia increased 310%. Decreases in reported septicemia were seen after increases in the proportion of beneficiaries in Medicare health maintenance organizations. Discharge rates for septicemia principal diagnoses increased steeply with age. Age-specific discharge rates were usually highest for black men and lowest for white women. Exceptions included septicemia due to E. coli, with white men at low risk, and pneumococcal septicemia, without significant differences between races or sexes. The case-fatality rate in hospital ranged from 4.2% with 'bacteremia' and 6.9% with E. coli septicemia to 22.2% with 'septicemia due to gram-negative organism, unspecified,' and 26.8% with 'unspecified septicemia.' Staphylococcal septicemia, septicemia due to pseudomonas, and septicemia due to anaerobes were the costliest common principal diagnoses in terms of the mean duration of hospital stay. CONCLUSIONS: Unexplained sharp increases were reported in hospitalization for septicemia or bacteremia in elderly Americans. Marked variation by race and sex were evident in discharge rates with these principal diagnoses. Prognosis and average cost of treatment also differed substantially among common rubrics. Further investigation of individual diagnoses should concentrate on explaining secular trends, exploring the basis for variation by race and sex, and elucidating risk factors for poor clinical outcomes.
SN - 1047-2797
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, 6010 Executive Boulevard, Rockville, MD 20852-3813
U2 - PMID: 11164128.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Boiano, James M.
AU - Hull, R. Delon
T1 - Development of a National Occupational Exposure Survey and Database Associated with NIOSH Hazard Surveillance Initiatives.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 128
EP - 134
PB - Taylor & Francis Ltd
SN - 1047322X
AB - NIOSH pioneered hazard surveillance in the workplace by designing and conducting the 1972 to 1974 National Occupational Hazard Survey (NOHS), the 1981 to 1983 National Occupational Exposure Survey (NOES), and the 1984 to 1989 National Occupational Health Survey of Mining (NOHSM). The databases developed from these three on-site surveys represent unique resources for associating potential chemical, physical and biological agents with industries and occupational groups. The data have been a primary source of information for NIOSH, regulatory agencies, health professionals, researchers, and labor organizations in establishing priorities for prevention strategies that include medical and engineering interventions, development of occupational standards, and the identification of research needs. Recognizing that the data from these surveys are becoming dated, a multidisciplinary team comprising members from various NIOSH research divisions was established to develop a hazard surveillance strategy for the Institute, including options for a national hazard surveillance survey and database. The proposed new hazard survey builds on lessons learned from the previous surveys, seeks opportunities to incorporate existing data from other sources, expands the scope of industries and hazards, and takes advantage of advances in data gathering, processing and dissemination technology. This article presents current considerations and recommendations for a new hazard survey and database. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Databases
KW - EXPOSURE DATABASES
KW - OCCUPATIONAL HAZARD SURVEILLANCE
N1 - Accession Number: 4230191; Boiano, James M. 1; Hull, R. Delon 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Feb2001, Vol. 16 Issue 2, p128; Thesaurus Term: Industrial hygiene; Subject Term: Databases; Author-Supplied Keyword: EXPOSURE DATABASES; Author-Supplied Keyword: OCCUPATIONAL HAZARD SURVEILLANCE; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/104732201460217
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hewett, Paul
T1 - Misinterpretation and Misuse of Exposure Limits.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 251
EP - 256
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Users of occupational exposure limits (OELs) often fail to distinguish between the complementary processes of risk assessment and exposure (risk) management. The former refers to those activities that lead to the selection of a reasonably protective exposure limit and often includes an analysis of exposure databases and an evaluation of group-based risk. The latter focuses on individual risk, and refers to those actions required of employers to ensure that each employee is unlikely to incur harm to health. This presentation focuses on how this failure to distinguish leads to misinterpretation and misuse of OELs. A typical OEL definition consists of at least three components: a concentration, an averaging time, and a target (usually the individual worker). OELs are occasionally improperly applied, resulting in a reduction of the expected level of protection. For example, sampling strategies proposed by the American Industrial Hygiene Association (AIHA) and Comité Européen de Normalisation (CEN) permit workers to be aggregated into exposure groups. Under certain circumstances this practice can leave some workers unevaluated and unprotected. Protection is also reduced when the averaging time is extended from a single shift to multiple shifts. Frequently, OELs are misinterpreted as upper limits to exposures averaged over weeks, months, or even years, rather than a single shift. Much of this confusion can be traced to the desire of some to reconcile research (epidemiology) sampling strategies with compliance sampling strategies. But the two have fundamentally different goals and objectives. Others are simply attracted to alternative OEL interpretations that permit frequent overexposures (i.e., measurements that exceed the OEL), thus making compliance easier. Given the current limitations of industrial hygiene and occupational epidemiology, and the general unwillingness of employers to routinely collect exposure data, OELs should continue to be defined as upper limits for single shift exposures. The current OEL model, which permits the use of proximate risk management goals to realize long-range objectives, should be retained. There are, however, valid reasons for augmenting this model to include criteria for evaluating compliance with long-range objectives. The augmented OEL model would be applicable to future new and revised OELs. The author suggests that OEL setting organizations consider harmonizing definitions and statistical interpretations for bothexisting and new OELs, thus minimizing future misinterpretation and misuse. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Threshold limit values (Industrial toxicology)
KW - Industrial hygiene
KW - Epidemiology
N1 - Accession Number: 4230169; Hewett, Paul 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Feb2001, Vol. 16 Issue 2, p251; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Industrial hygiene; Thesaurus Term: Epidemiology; Number of Pages: 6p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1080/104732201460415
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Risi, Dave
AU - Dobbin, Denny
AU - Zaebst, Dennis
AU - Tischer, Martin
T1 - Workshop on Harmonization of Serving Multiple Needs with Occupational Exposure Databases, Session II.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 304
EP - 308
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Highlights the workshop, 'Harmonization of Serving Multiple Needs with Occupational Exposure Databases (Session II)' in London, England. Goal of the workshop to determine users and the use of occupational exposure database; Identification of key parameters for exposure databases; List of guide areas identified by the workshop.
KW - Industrial toxicology
KW - Databases -- Congresses
KW - England
KW - London (England)
N1 - Accession Number: 4230160; Risi, Dave 1; Dobbin, Denny 2; Zaebst, Dennis 3; Tischer, Martin 4; Affiliations: 1: Atrion International, Inc., Reston, Virginia; 2: ACGIH Computer Committee, Chapel Hill, North Carolina; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 4: Federal Institute of Occupational Safety and Health, Dortmund, Germany; Issue Info: Feb2001, Vol. 16 Issue 2, p304; Thesaurus Term: Industrial toxicology; Subject Term: Databases -- Congresses; Subject: England; Subject: London (England); Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/104732201460505
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tickner, John
AU - Armstrong, Thomas W.
AU - Bloom, Thomas F.
T1 - Workshop on Harmonization of Serving Future Needs with Occupational Exposure Databases—Inhalation Modeling, Session IIIA.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 309
EP - 314
PB - Taylor & Francis Ltd
SN - 1047322X
AB - This workshop was one of several that took place at the International Symposium on Occupational Exposure Databases and Their Application for the Next Millennium held in London from November 1–3, 1999. About 30 delegates participated in the workshop. The agenda for the discussions was provided by a white paper prepared by the organizers. The workshop produced a conceptual outline for a general-purpose prediction model for inhalation exposure, and constructed a list of important input variables for successful model development. Evaluation of prototype models was discussed in some detail, and the workshop concluded with suggestions for taking forward the ideas discussed and maintaining the momentum and interest generated during the symposium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial toxicology
KW - Databases -- Congresses
KW - England
KW - London (England)
N1 - Accession Number: 4230158; Tickner, John 1; Armstrong, Thomas W. 2; Bloom, Thomas F. 3; Affiliations: 1: Health and Safety Executive, United Kingdom; 2: ExxonMobil Biomedical Sciences, Inc; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Feb2001, Vol. 16 Issue 2, p309; Thesaurus Term: Industrial toxicology; Subject Term: Databases -- Congresses; Subject: England; Subject: London (England); Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/104732201460514
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Abell, Martin T.
AU - Woebkenberg, Mary Lynn
AU - Armstrong, Thomas W.
AU - Stenzel, Mark
T1 - Research Recommendations of the NORA Exposure Assessment Methods Team.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 331
EP - 333
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Focuses on research recommendations of the National Occupational Research Agenda, a framework to guide occupational safety by the exposure assessment methods (EAM) team in the United States. Aims of the EAM team; Concept of exposure assessment.
KW - Industrial hygiene
KW - Industrial safety
KW - United States
N1 - Accession Number: 4230153; Abell, Martin T. 1; Woebkenberg, Mary Lynn 1; Armstrong, Thomas W. 2; Stenzel, Mark 3; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey; 3: Occidental Chemical Corporation, Dallas, Texas; Issue Info: Feb2001, Vol. 16 Issue 2, p331; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Subject: United States; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/104732201460569
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106987520
T1 - Federal efforts to improve quality of care: the Quality Interagency Coordination Task Force (QuIC)
AU - Eisenberg JM
AU - Foster NE
AU - Meyer G
AU - Holland H
Y1 - 2001/02//2001 Feb
N1 - Accession Number: 106987520. Language: English. Entry Date: 20021213. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9315239.
KW - National Health Programs
KW - Health Care Delivery
KW - Quality Improvement
KW - Public Policy
KW - Government Agencies
KW - Goals and Objectives
KW - Practice Guidelines
KW - Diabetes Mellitus -- Therapy
KW - Depression -- Diagnosis
KW - Depression -- Therapy
KW - Work Environment
KW - Patient Safety
KW - Consumer Health Information
KW - Mandatory Reporting
KW - Professional Practice, Evidence-Based
KW - United States Department of Veterans Affairs
KW - United States Centers for Medicare and Medicaid Services
KW - Interinstitutional Relations
KW - United States
SP - 93
EP - 100
JO - Joint Commission Journal on Quality Improvement
JF - Joint Commission Journal on Quality Improvement
JA - JOINT COMM J QUAL IMPROV
VL - 27
IS - 2
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1070-3241
AD - Director, Agency for Healthcare Research and Quality, 2101 E Jefferson St, Rockville, MD 20852; jeisenbe@ahrq.gov
U2 - PMID: 11221014.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Kodell, Ralph L.
T1 - Dose-Response Trend Tests for Tumorigenesis Adjusted for Differences in Survival and Body Weight across Doses.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/02//
VL - 59
IS - 2
M3 - Article
SP - 219
EP - 225
PB - Oxford University Press / USA
SN - 10966080
AB - A relationship between rodent body weight and tumor incidence for some tissue/organ sites has been demonstrated in many studies. It is not uncommon for a chemical tested for carcinogenicity to also affect body weight due to toxicity and/or food consumption. In such cases, comparisons of tumor incidence may be biased by body weight differences across dose groups. A simple procedure was investigated for reducing this bias. This procedure divides the animals into a few groups on the basis of body weight. Body weight at 12 months was used, before the appearance of a tumor was likely to affect body weight. Statistics for dose-response trend tests are calculated within body weight strata and pooled to obtain an overall dose-response trend test. This procedure is analogous to stratifying animals on the basis of age at the time of removal from a study to account for differences in ages of animals across dose groups that can affect comparisons of tumor incidence. In this paper, differences in survival times of animals were adjusted by the Poly-3 technique used by the National Toxicology Program. This technique does not require the assignment of cause of death. Several examples from rodent chronic bioassays were investigated, where the high dose group had reduced body weights and associated reductions in tumor incidence. When we analyzed the data by body weight strata, some positive dose-response trends for tumor incidence were demonstrated. In one case, the body weight adjusted analysis indicated that a negative dose-response trend in tumor incidence was a real effect in addition to a body weight reduction. These examples indicate that it is important to consider the effects of body weight changes as low as 10%, and perhaps less, as possibly being caused by chemicals in 2-year bioassays for carcinogenesis. The simple procedure of analyzing tumor incidence within body weight strata can reduce the bias introduced by body weight differences across dose groups. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity
KW - Food consumption
KW - Carcinogenesis
KW - Animals
KW - Body weight
KW - Tumors
KW - body weight
KW - dose response
KW - Poly-3
KW - trend test
KW - tumorigenesis
N1 - Accession Number: 44406076; Gaylor, David W. 1; Email Address: dgaylor@sciences.com; Kodell, Ralph L. 1; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Feb2001, Vol. 59 Issue 2, p219; Thesaurus Term: Carcinogenicity; Thesaurus Term: Food consumption; Thesaurus Term: Carcinogenesis; Thesaurus Term: Animals; Subject Term: Body weight; Subject Term: Tumors; Author-Supplied Keyword: body weight; Author-Supplied Keyword: dose response; Author-Supplied Keyword: Poly-3; Author-Supplied Keyword: trend test; Author-Supplied Keyword: tumorigenesis; Number of Pages: 7p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2001-14399-003
AN - 2001-14399-003
AU - Wysowski, Diane K.
AU - Pitts, Marilyn
AU - Beitz, Julie
T1 - Depression and suicide in patients treated with isotretinoin.
JF - The New England Journal of Medicine
JO - The New England Journal of Medicine
JA - N Engl J Med
Y1 - 2001/02//
VL - 344
IS - 6
SP - 460
EP - 460
CY - US
PB - Massachusetts Medical Society
SN - 0028-4793
SN - 1533-4406
N1 - Accession Number: 2001-14399-003. PMID: 11221610 Other Journal Title: Boston Medical & Surgical Journal. Partial author list: First Author & Affiliation: Wysowski, Diane K.; Food and Drug Administration, Rockville, MD, US. Release Date: 20010221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Drugs; Major Depression; Side Effects (Drug); Skin Disorders; Suicide. Minor Descriptor: Attempted Suicide; Drug Therapy; Suicidal Ideation. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 1. Issue Publication Date: Feb, 2001.
AB - Briefly discusses reports received by the Food and Drug Administration of 431 cases of depression, suicidal ideation, suicide attempts, or suicide in US patients treated with isotretinoin, which is indicated for the treatment of severe nodular acne. Physicians should request that patients and their parents report promptly any changes in behavior that might be symptomatic of depression so that patients may be evaluated for appropriate treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - isotretinoin & depression & suicidal ideation & suicide attempts or suicide
KW - patients with severe nodular acne
KW - 2001
KW - Drugs
KW - Major Depression
KW - Side Effects (Drug)
KW - Skin Disorders
KW - Suicide
KW - Attempted Suicide
KW - Drug Therapy
KW - Suicidal Ideation
KW - 2001
DO - 10.1056/NEJM200102083440616
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107076375
T1 - Perspectives in leadership. Opportunity knocks -- will you listen?
AU - Sparber A
Y1 - 2001/02/05/2001 Feb 5
N1 - Accession Number: 107076375. Language: English. Entry Date: 20011214. Revision Date: 20150711. Publication Type: Journal Article; interview. Journal Subset: Nursing; USA. NLM UID: 9421079.
KW - Nursing Leaders
KW - Alternative Therapies
SP - 10
EP - 11
JO - Nursing Spectrum -- Washington DC & Baltimore Edition
JF - Nursing Spectrum -- Washington DC & Baltimore Edition
JA - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL - 11
IS - 3
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1098-9153
AD - Captain, US Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Young, John F.
AU - Gough, Bobby J.
AU - Suber, Robert L.
AU - Gaylor, David W.
T1 - CORRELATION OF BLOOD CHOLINESTERASE LEVELS WITH TOXICITY OF SARIN IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2001/02/09/
VL - 62
IS - 3
M3 - Article
SP - 161
EP - 174
SN - 15287394
AB - The dose-mortality response curve for sarin when administered to pregnant rats is extremely steep. The pregnant animal either died during the treatment or survived with no observable fetal toxicity. Animals that died displayed many symptoms characteristic of anticholinesterase toxicity. The present study was conducted to determine whether the maternal deaths, clinical observations, and/or weight loss could be correlated with baseline blood cholinesterase levels in individual animals. Cholinesterase levels (plasma and erythrocyte) were obtained prior to, during, and following treatment of nonpregnant rats by gavage with 380 µg/kg/d sarin for 10 d. After the first dose, there was a drop in the plasma cholinesterase levels, which then remained low throughout the dosing period. There was a statistically significant correlation between body weight loss and plasma cholinesterase levels of the sarin dosed animals. The surviving animals also had lower plasma cholinesterase levels and lower body weights, both of which recovered on the cessation of dosing. The erythrocyte cholinesterase levels were not different between treated and nontreated rats. Neither plasma or erythrocyte baseline cholinesterase levels nor relative or absolute cholinesterase decline values could be used as predictors of mortality from sarin administration in rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sarin
KW - Toxicology
KW - Rats as laboratory animals
KW - Cholinesterases
N1 - Accession Number: 4783477; Young, John F. 1; Gough, Bobby J. 1; Suber, Robert L. 2; Gaylor, David W. 1; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA; 2: Bowman Gray Technical Center, RJR Nabisco, Inc., Winston-Salem, North Carolina, USA; Issue Info: 2001, Vol. 62 Issue 3, p161; Thesaurus Term: Sarin; Thesaurus Term: Toxicology; Subject Term: Rats as laboratory animals; Subject Term: Cholinesterases; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/009841001458280
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107020545
T1 - Impact of added rest breaks on the productivity and well being of workers.
AU - Dababneh AJ
AU - Swanson N
AU - Shell RL
Y1 - 2001/02/10/2001 Feb 10
N1 - Accession Number: 107020545. Language: English. Entry Date: 20010504. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Productivity
KW - Personnel Staffing and Scheduling
KW - Comfort
KW - Psychological Well-Being
KW - Stress, Occupational
KW - Workload Measurement
KW - Stress, Physiological -- Evaluation
KW - Stress, Psychological -- Evaluation
KW - Videorecording
KW - Time Factors
KW - One-Way Analysis of Variance
KW - Repeated Measures
KW - T-Tests
KW - Questionnaires
KW - Two-Way Analysis of Variance
KW - Employee Attitudes -- Evaluation
KW - Descriptive Statistics
KW - Affect -- Evaluation
KW - Human
SP - 164
EP - 174
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 44
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, C24, Cincinnati, OH 45226-1998; awwad@ti.com
U2 - PMID: 11209875.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
ID - 89254805
T1 - Gemcitabine and cisplatin for advanced, metastatic bladder cancer.
AU - Cohen, Martin H.
AU - Rothmann, Mark
AU - von der Maase, Hans
AU - Hayden, Anna Marie
AU - Cohen, M H
AU - Rothmann, M
Y1 - 2001/02/15/
N1 - Accession Number: 89254805. Language: English. Entry Date: 20010622. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Deoxycytidine -- Therapeutic Use
KW - Cisplatin -- Therapeutic Use
KW - Carcinoma, Transitional Cell -- Drug Therapy
KW - Antineoplastic Agents, Combined -- Urine
KW - Bladder Neoplasms -- Drug Therapy
KW - Vinblastine -- Therapeutic Use
KW - Human
KW - Neoplasm Metastasis
KW - Deoxycytidine
KW - Doxorubicin -- Therapeutic Use
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Methotrexate -- Therapeutic Use
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 1229
EP - 1231
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 4
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - United States Food and Drug Administration, Rockville, MD
AD - Aarhus University Hospital, Aarhus, Denmark
AD - Eli Lilly and Company, Indianapolis, IN
U2 - PMID: 11181690.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107050740
T1 - Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use.
AU - Koehler KM
AU - Baumgartner RN
AU - Garry PJ
AU - Allen RH
AU - Stabler SP
AU - Rimm EB
Y1 - 2001/03//
N1 - Accession Number: 107050740. Language: English. Entry Date: 20010907. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Health Habits and History Questionnaire (HHHQ). Grant Information: Supported in part by research grants AG02049, AG10149, AG09834, and NCRR-GCRC M01RR00997 from the National Institutes of Health. NLM UID: 0376027.
KW - Folic Acid -- Administration and Dosage
KW - Homocysteine -- Blood
KW - Alcohol Drinking
KW - Dietary Supplementation
KW - Clinical Assessment Tools
KW - Diet
KW - Vascular Diseases -- Etiology
KW - Dose-Response Relationship, Drug
KW - Linear Regression
KW - Interviews
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Chi Square Test
KW - Multiple Linear Regression
KW - Spearman's Rank Correlation Coefficient
KW - Questionnaires
KW - Aged
KW - Female
KW - Male
KW - Funding Source
KW - Human
SP - 628
EP - 637
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 73
IS - 3
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - BACKGROUND: The serum total homocysteine concentration (tHcy), an indicator of folate status and a possible risk factor for vascular disease, is elevated with impaired renal function and poor vitamin B-12 status, which are common in the elderly. OBJECTIVE: Our objective was to determine the association between tHcy, folate intake, alcohol consumption, and other lifestyle factors in elderly persons. DESIGN: This cross-sectional study used linear regression to model changes in tHcy. Subjects were 278 men and women aged 66-94 y studied in 1993. RESULTS: Total folate intake was negatively associated with tHcy in models adjusted for age, sex, serum creatinine, and serum albumin. We found an interaction between food folate intake and supplement use. Food folate intake had an inverse dose-response relation with tHcy that was limited to nonusers of supplements. Predicted tHcy was 1.5 micromol/L lower in users of supplements containing folate and vitamin B-12 than in nonusers and was independent of food folate intake. We found a positive dose-response relation of coffee and tea intake with tHcy, a positive association for alcohol intake of > or = 60 drinks/mo compared with low intake, and an interaction of alcohol use with folate intake and supplement use. Compared with alcohol users, nonusers had higher predicted tHcy and a lower inverse dose-response relation of food folate intake with tHcy. CONCLUSIONS: The inverse association between folate intake and tHcy was strongest among nonusers of supplements and among alcohol drinkers. Identifying modifiable factors related to tHcy, a possible risk factor for vascular disease, is especially important in elderly persons. Copyright © 2001 American Society for Clinical Nutrition
SN - 0002-9165
AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-728, 200 C Street SW, Washington, DC 20204. E-mail: kathleen.koehler@cfsan.fda.gov
U2 - PMID: 11237942.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Holman, Robert C.
AU - Curns, Aaron T.
AU - Kaufman, Stephen F.
AU - Cheek, James E.
AU - Pinner, Robert W.
AU - Schonberer, Lawrence B.
T1 - Trends in Infectious Disease Hospitalizations Among American Indians and Alaska Natives.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/03//
VL - 91
IS - 3
M3 - Article
SP - 425
EP - 431
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study sought to describe trends in hospitalizations associated with infectious diseases among American Indians and Alaska Natives. Methods. Infectious disease hospitalizations and rates among American Indians and Alaska Natives from 1980 through 1994 were examined via Indian Health Service hospital discharge data and compared with published trends for the general US population. Results. Annual hospitalization rates for infectious diseases among American Indians and Alaska Natives decreased by 31.0% between 1980 and 1994. Infectious disease hospitalizations accounted for 16.3% of all hospitalizations in 1980 and 21.2% in 1994, an increase of 30.1%. In 1994, the age-adjusted infectious disease hospitalization rate for American Indians and Alaska Natives was 1863 per 100000 population, approximately 21% greater than that for the general US population. Conclusions. Hospitalization trends for infectious diseases show that there has been improvement in the health stares of American Indians and Alaska Natives but also indicate that this population has a higher infectious disease burden than the general US population. (Am J Public Health. 2001;91:425-431) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - POPULATION
KW - Hospital care
KW - Native Americans
KW - United States
N1 - Accession Number: 4147467; Holman, Robert C. 1; Curns, Aaron T. 1; Kaufman, Stephen F. 2; Cheek, James E. 3; Pinner, Robert W. 4; Schonberer, Lawrence B. 1; Affiliations: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga.; 2: Indian Health Service, Rockville, Md.; 3: Epidemiology Program, Office of Public Health, Indian Health Service, Albuquerque, NM.; 4: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga.; Issue Info: Mar2001, Vol. 91 Issue 3, p425; Thesaurus Term: Communicable diseases; Thesaurus Term: POPULATION; Subject Term: Hospital care; Subject Term: Native Americans; Subject: United States; Number of Pages: 7p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107030035
T1 - Measurement of radiated electromagnetic field levels before and after a changeover to energy-efficient lighting.
AU - Kerr LN
AU - Boivin WS
AU - Boyd SM
AU - Coletta JN
AU - Kerr, L N
AU - Boivin, W S
AU - Boyd, S M
AU - Coletta, J N
Y1 - 2001/03//2001 Mar-Apr
N1 - Accession Number: 107030035. Language: English. Entry Date: 20010615. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Electromagnetic Fields
KW - Lighting -- Equipment and Supplies
KW - Equipment Failure
KW - Radio Waves
KW - In Vitro Studies
KW - Human
SP - 104
EP - 109
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 35
IS - 2
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - An energy-efficient lighting retrofit at the Food and Drug Administration (FDA) Winchester Engineering and Analytical Center (WEAC) presented the opportunity to measure the electromagnetic (EM) environments in several rooms before and after changing the fluorescent lighting systems and to compare the changes in EM fields with the proposed standard EM immunity levels. Three rooms, representing the types of work areas in the laboratory, were selected and measured before and after the lighting changeover. Electric and magnetic field measurements were taken in the extremely low frequency (ELF), very low frequency (VLF), and radio frequency (RF) ranges of the EM spectrum. In 2 rooms, ELF electric fields were reduced and VLF and RF electric fields were increased as a result of the changeover to high-frequency fixtures. A third room received low-frequency, energy-efficient fixtures during this changeover, and this change resulted in only a slight increase of the ELF electric fields. The ELF magnetic fields were greatly reduced in 2 but only slightly reduced in the third room. No significant change was seen in VLF or RF magnetic fields for any of these rooms. Some field-strength measurements exceeded the proposed immunity levels recommended in the draft International Electrotechnical Commission standard IEC 60601-1-2 (rev. 2). The data show that increasing the separation distance from the fluorescent light fixtures greatly reduces the field-strength levels, limiting the potential for EM interference.
SN - 0899-8205
AD - US Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St, Winchester, MA 01890, USA
AD - US Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St, Winchester, MA 01890; lkerr@ora.fda.gov
U2 - PMID: 11383307.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clark, H. Westley
T1 - Residential Substance Abuse Treatment for Pregnant and Postpartum Women and Their Children: Treatment and Policy Implications.
JO - Child Welfare
JF - Child Welfare
Y1 - 2001/03//Mar/Apr2001
VL - 80
IS - 2
M3 - Article
SP - 179
EP - 198
PB - Child Welfare League of America
SN - 00094021
AB - In FY 1993 and FY 1995, the federal government awarded 27 five-year grants that supported 35 residential treatment projects for substance-abusing pregnant and postpartum women and their children. These projects provided comprehensive culturally and gender-specific treatment. Preliminary aggregated data collected in a national cross-site evaluation of 24 of these projects are encouraging with respect to infant mortality and morbidity, treatment retention and completion rates, and behavioral changes in the participating mothers at six months postdischarge. Local evaluations reflect other benefits of treatment. Cost data are expected to demonstrate the efficiencies and benefits of these projects compared to no treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Child Welfare is the property of Child Welfare League of America and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANT women -- Services for
KW - SUBSTANCE abuse -- Treatment
KW - FAMILY services
KW - WOMEN -- Services for
KW - INFANT mortality
KW - SOCIAL services
KW - COMMUNITY-based social services
KW - HUMAN services
KW - UNITED States
N1 - Accession Number: 4273528; Clark, H. Westley 1; Source Information: Mar/Apr2001, Vol. 80 Issue 2, p179; Subject: SUBSTANCE abuse; Subject: PREGNANT women -- Services for; Subject: SUBSTANCE abuse -- Treatment; Subject: FAMILY services; Subject: WOMEN -- Services for; Subject: INFANT mortality; Subject: SOCIAL services; Subject: COMMUNITY-based social services; Subject: HUMAN services; Geographic Terms: UNITED States; Number of Pages: 20p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5641
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106920934
T1 - Residential substance abuse treatment for pregnant and postpartum women and their children: treatment and policy implications.
AU - Clark HW
Y1 - 2001/03//Mar/Apr2001
N1 - Accession Number: 106920934. Language: English. Entry Date: 20020503. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0372735.
KW - Prenatal Care
KW - Postnatal Care
KW - Substance Abuse, Perinatal -- Rehabilitation
KW - Maternal Health Services
KW - Residential Care
KW - Program Evaluation
KW - Cultural Sensitivity
KW - Treatment Outcomes -- Evaluation
KW - Residential Care -- Economics
KW - Grants
KW - Public Policy
KW - United States
KW - Pregnancy Outcomes -- Evaluation
KW - Adult
KW - Pregnancy
KW - Female
SP - 179
EP - 198
JO - Child Welfare
JF - Child Welfare
JA - CHILD WELFARE
VL - 80
IS - 2
CY - Washington, District of Columbia
PB - Child Welfare League of America
SN - 0009-4021
AD - Director, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD
U2 - PMID: 11291900.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Succop, P.
AU - Clark, S.
AU - Tseng, C.-Y.
AU - Bornschein, R.
AU - Chen, M.
T1 - Evaluation of Public Housing Lead Risk Assessment Data.
JO - Environmental Geochemistry & Health
JF - Environmental Geochemistry & Health
Y1 - 2001/03//
VL - 23
IS - 1
M3 - Article
SP - 1
EP - 15
PB - Springer Science & Business Media B.V.
SN - 02694042
AB - A unique data set from lead risk assessments performed on 67 public housing developments from across the United States was made available for analyzes. The data set includes results of lead analysis from 5906 dust wipes and from 1222 soil samples. A total of 487 dwelling units in these developments, as well as associated common areas, were sampled, all by the same team of inspectors. The number of dwelling units within a development that were sampled reflected the guidelines then in force, the 1990 Interim HUD Guidelines, rather than those specified in the 1995 Guidelines. Median dust lead loadings for floors, 151 μg m-2 (14 μg ft-2), and window sills, 936 μg m-2 (87 μg ft-2), were much less than former HUD limits of 1076 μg m-2 (100 μg ft-2) and 5380 μg m-2 (500 μg ft-2), respectively and are only about one-third of the recently established limits of 431 μg m-2 (40 μg ft-2) and 2690 μg m-2 (250 μg ft-2). In contrast, the median lead loading for window troughs, 8560 μg m-2 (795 μg ft-2), was almost identical to the HUD clearance limit of 8610 μg m-2 (800 μg ft-2). There was a strong positive correlation between floor and window trough lead loading values for samples from the same dwelling units and those from common areas of the housing developments. Door threshold samples, which may reflect conditions exterior to the dwelling unit, were collected from 53 dwelling units. Median lead loading levels of these samples were more than ten times higher than those in floor samples from the same dwelling units, were about the same as window sill samples and about one-half of levels in window trough samples. Composite sample results, simulated by averaging results from four samples within a dwelling unit, revealed that in order to have the same rate of excedence of standards, the composite standards would have to be reduced, for example, from the single sample value of 1076 μg m-2 (100 μg ft-2) to 527 μg m-2 (49 μg ft-2) for floor samples and from the single sample value of 8610 μg m-2 (800 μg ft-2) to 5160 μg m-2 (479 μg ft-2) for window troughs. For this public housing data set, the portion of the units in developments containing more than 225 units which exceeded the established limit for window samples was the same when using either the full data set or a random one-half of the data set. This suggests that, for this data set, the number of dwelling units sampled was excessive . Thus, the required increase in the number of dwelling units to be sampled specified in the 1995 Guidelines for developments with more than 225 dwelling units, may not have been necessary if this data set is representative of public housing developments in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Geochemistry & Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dust
KW - Soils
KW - Public housing
KW - Evaluation
KW - Real estate development
KW - United States
KW - housing
KW - lead dust
KW - lead poisoning
KW - public housing
KW - risk assessment
KW - soil lead
N1 - Accession Number: 16935616; Succop, P. 1; Clark, S. 1; Tseng, C.-Y. 2; Bornschein, R. 1; Chen, M. 1; Affiliations: 1: Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH, USA.; 2: National Institute for Occupational Safety and Health, Cincinnati, OH, USA.; Issue Info: Mar2001, Vol. 23 Issue 1, p1; Thesaurus Term: Dust; Thesaurus Term: Soils; Subject Term: Public housing; Subject Term: Evaluation; Subject Term: Real estate development; Subject: United States; Author-Supplied Keyword: housing; Author-Supplied Keyword: lead dust; Author-Supplied Keyword: lead poisoning; Author-Supplied Keyword: public housing; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: soil lead; NAICS/Industry Codes: 531112 Lessors of social housing projects; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Humphreys, Susie H.
AU - Carrington, Clark
AU - Bolger, Michael
T1 - A quantitative risk assessment for fumonisins B[sub 1] and B[sub 2] in US corn.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2001/03//
VL - 18
IS - 3
M3 - Article
SP - 211
EP - 220
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Quantitative risk analysis permits modifying risk estimates with changes in variables such as exposure. This analysis for exposure to the mycotoxin fumonisin describes the magnitude of adverse effects, variability in the population and uncertainty of models as a range of possible outcomes. The most sensitive adverse response in rats, nephrotoxic lesions, was used for the dose-response analysis. Dietary intake of corn products was estimated from a 3-day consumption survey. Levels of corn in each product were estimated by standard methods. Fumonisin levels in corn products were estimated from Food and Drug Administration (FDA) surveillance data and distributions of fumonisin consumption were modelled for each eater in the survey population. Uncertainty for predictions made from each model and uncertainty resulting from model selection were described. Results of the dose-response and exposure analyses were assimilated in a two-dimensional Monte-Carlo simulation. Distributions representing variability and uncertainty were iteratively selected to form an array of estimates of the risk. On the basis of this analysis, current dietary levels of fumonisin would not result in renal lesions even at upper levels of exposure. To avoid toxicity at much higher doses, limiting corn intake would be more effective than would limiting the level of fumonisin in corn. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Fumonisins
KW - Corn products
KW - Monte Carlo method
KW - United States
KW - Exposure assessment
KW - Monte Carlo simulation
KW - Mycotoxins
KW - NEPHROTOXICITY
N1 - Accession Number: 4273364; Humphreys, Susie H. 1; Carrington, Clark 1; Bolger, Michael 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; Issue Info: Mar2001, Vol. 18 Issue 3, p211; Thesaurus Term: Risk assessment; Subject Term: Fumonisins; Subject Term: Corn products; Subject Term: Monte Carlo method; Subject: United States; Author-Supplied Keyword: Exposure assessment; Author-Supplied Keyword: Monte Carlo simulation; Author-Supplied Keyword: Mycotoxins; Author-Supplied Keyword: NEPHROTOXICITY; NAICS/Industry Codes: 311221 Wet Corn Milling; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1080/02652030010021486
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kodell, R. L.
AU - Young, J. F.
AU - Delongchamp, R. R.
AU - Turturro, A.
AU - Chen, J. J.
AU - Gaylor, D. W.
AU - Howard, P. C.
AU - Zheng, Q.
T1 - A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B[sub 1] in the diet.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2001/03//
VL - 18
IS - 3
M3 - Article
SP - 237
EP - 253
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Data from the National Toxicology Program's carcinogenesis study of fumonisin B[sub 1] in B6C3F[sub 1] mice, conducted at the National Center for Toxicological Research, were used to fit the Moolgavkar-Venzon-Knudson (MVK) two-stage, clonal-expansion model of carcinogenesis. In addition to tumour data from the conventional 2-year bioassay, the study included data on tissue weights, cell proliferation, cell death, and sphingolipid metabolism in primary target organs. The model was used to predict 2-year liver tumour rates in female and male mice based on differences among dose groups in the effect of fumonisin B[sub 1] on the growth of normal tissue and on the proliferation of preneoplastic cells as a compensatory response to sphinganine-induced cell death. Fumonisin B[sub 1] was assumed to be non-genotoxic, i.e. the model did not include any effect of fumonisin B[sub 1] on either of the two mutation rates of the MVK model. The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B[sub 1] in females. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Liver tumors
KW - Fumonisins
KW - Precancerous conditions
KW - COMPENSATORY PROLIFERATION
KW - MVK MODEL
KW - Non-genotoxic
KW - Sphingolipid metabolism
N1 - Accession Number: 4273360; Kodell, R. L. 1; Young, J. F. 1; Delongchamp, R. R. 1; Turturro, A. 1; Chen, J. J. 1; Gaylor, D. W. 1; Howard, P. C. 1; Zheng, Q. 1; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Mar2001, Vol. 18 Issue 3, p237; Subject Term: Liver tumors; Subject Term: Fumonisins; Subject Term: Precancerous conditions; Author-Supplied Keyword: COMPENSATORY PROLIFERATION; Author-Supplied Keyword: MVK MODEL; Author-Supplied Keyword: Non-genotoxic; Author-Supplied Keyword: Sphingolipid metabolism; Number of Pages: 17p; Illustrations: 2 Diagrams, 12 Graphs; Document Type: Article
L3 - 10.1080/02652030010021972
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TY - JOUR
AU - Henneberger, Paul K.
AU - Cumro, Debra
AU - Deubner, David D.
AU - Kent, Michael S.
AU - McCawley, Michael
AU - Kreiss, Kathleen
T1 - Beryllium sensitization and disease among long-term and short-term workers in a beryllium ceramics plant.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2001/03//
VL - 74
IS - 3
M3 - Article
SP - 167
EP - 176
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Objective: Workers at a beryllium ceramics plant were tested for beryllium sensitization and disease in 1998 to determine whether the plant-wide prevalence of sensitization and disease had declined since the last screening in 1992; an elevated prevalence was associated with specific processes or with high exposures; exposure-response relationships differed for long-term workers hired before the last plant-wide screening and short-term workers hired since then. Methods: Current workers were asked to complete a questionnaire and to provide blood for the beryllium lymphocyte proliferation test (BeLPT). Those with an abnormal BeLPT were classified as sensitized, and were offered clinical evaluation for beryllium disease. Task- and time-specific measurements of airborne beryllium were combined with individual work histories to compute mean, cumulative, and peak beryllium exposures for each worker. Results: The 151 participants represented 90% of 167 eligible workers. Fifteen (9.9% of 151) had an abnormal BeLPT and were split between long-term workers (8/77=10.4%) and short-term workers (7/74=9.5%). Beryllium disease was detected in 9.1% (7/77) of long-term workers but in only 1.4% (1/74) of short-term workers (P=0.06), for an overall prevalence of 5.3% (8/151). These prevalences were similar to those observed in the earlier survey. The prevalence of sensitization was elevated in 1992 among machinists, and was still elevated in 1998 among long-term workers (7/40=18%) but not among short-term workers (2/36=6%) with machining experience. The prevalence of sensitization was also elevated in both groups of workers for the processes of lapping, forming, firing, and packaging. The data suggested a positive relationship between peak beryllium exposure and sensitization for long-term workers and between mean, cumulative, and peak exposure and sensitization for short-term workers, although these findings were not statistically significant. Long-term workers with either a high peak exposure or work experience in forming were more likely to have an abnormal BeLPT (8/51=16%) than the other long-term workers (0/26, P=0.05). All seven sensitized short-term workers either had high mean beryllium exposure or had worked longest in forming or machining (7/55=13% versus 0/19, P=0.18). Conclusions: A plant-wide decline in beryllium exposures between the 1992 and 1998 surveys was not matched by a decline in the prevalence of sensitization and disease. Similar to findings from other studies, beryllium sensitization/disease was associated with specific processes and elevated exposures. The contrast in disease prevalence between long-term and short-term workers suggests that beryllium sensitization can occur after a short period of exposure, but beryllium disease usually requires a longer latency and/or period of exposure. The findings from this study motivated interventions to more aggressively protect and test workers, and new research into skin exposure as a route of sensitization and the contribution of individual susceptibility. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Industrial hygiene
KW - Diagnosis
KW - Blood
KW - Ceramics
KW - Medical research
KW - Beryllium disease
KW - Beryllium lymphocyte proliferation test
KW - Epidemiology
KW - Exposure-response
KW - Surveillance
N1 - Accession Number: 16129443; Henneberger, Paul K. 1; Email Address: pkh0@cdc.gov; Cumro, Debra 1; Deubner, David D. 2; Kent, Michael S. 2; McCawley, Michael 1; Kreiss, Kathleen 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M/S H-2800, Morgantown, WV 26505, USA.; 2: Brush Wellman, Incorporated, Elmore, Ohio, USA.; Issue Info: Mar2001, Vol. 74 Issue 3, p167; Thesaurus Term: Beryllium; Thesaurus Term: Industrial hygiene; Subject Term: Diagnosis; Subject Term: Blood; Subject Term: Ceramics; Subject Term: Medical research; Author-Supplied Keyword: Beryllium disease; Author-Supplied Keyword: Beryllium lymphocyte proliferation test; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Exposure-response; Author-Supplied Keyword: Surveillance; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 327110 Pottery, Ceramics, and Plumbing Fixture Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Drake, Pamela L.
AU - Rojas, Maritza
AU - Reh, Christopher M.
AU - Mueller, Charles A.
AU - Jenkins, F. Michael
T1 - Occupational exposure to airborne mercury during gold mining operations near El Callao, Venezuela.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2001/03//
VL - 74
IS - 3
M3 - Article
SP - 206
EP - 212
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Objective: The National Institute for Occupational Safety and Health (NIOSH) recently conducted a cross–sectional study during gold mining operations near El Callao, Venezuela. The purpose of the study was to assess mercury exposures and mercury-related microdamage to the kidneys. The study consisted of concurrent occupational hygiene and biological monitoring, and an examination of the processing techniques employed at the different mining facilities. Mercury was used in these facilities to remove gold by forming a mercury-gold amalgam. The gold was purified either by heating the amalgam in the open with a propane torch or by using a small retort. Methods: Thirty-eight workers participated in this study. Some participants were employed by a large mining company, while others were considered “informal miners” (self-employed). Mercury exposure was monitored by sampling air from the workers' breathing zones. These full-shift air samples were used to calculate time-weighted average (TWA) mercury exposure concentrations. A questionnaire was administered and a spot urine sample was collected. Each urine sample was analyzed for mercury, creatinine, and N-acetyl-ß-d-glucosaminidase (NAG). Results: The range for the 8-h TWA airborne mercury exposure concentrations was 0.1 to 6,315 μg/m3, with a mean of 183 μg/m3. Twenty percent of the TWA airborne mercury exposure measurements were above the NIOSH recommended exposure limit (REL) of 50 μg/m3, and 26% exceeded the American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value (TLV) of 25 μg/m3. The mean urine mercury concentration was 101 μg/g creatinine (μg/g-Cr), and the data ranged from 2.5 to 912 μg/g-Cr. Forty–two percent of the study participants had urine mercury concentrations that exceeded the ACGIH biological exposure index (BEI) of 35 μg/g-Cr. Urinary NAG excretion is considered a biological marker of preclinical, nonspecific microdamage to the kidney's proximal tubule cells. The mean urine NAG concentration was 3.6 International Units/g-Cr (IU/g-Cr) with a range of 0.5 to 11.5 IU/g-Cr. Three workers had urine NAG levels in excess of the reference values. Correlation analyses found statistically significant correlations between airborne mercury exposure and urine mercury level (P=0.01), and between urine mercury level and urine NAG excretion (P=0.01). In addition, the airborne mercury exposure data and urine mercury data were segregated by job tasks. A Wilcoxon rank sum test revealed significant correlations between tasks and mercury exposure (P=0.03), and between tasks and urine mercury level (P=0.02). Conclusions: The tasks with the highest mean airborne mercury exposures were “burning the mercury-gold amalgam” and “gold refining/smelting”. Recommendations were provided for improving the retort design to better contain mercury, for ventilation in the gold shops, and for medical surveillance and educational programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Industrial hygiene
KW - Health education
KW - Urinary organs
KW - Allied health personnel
KW - Public health personnel
KW - Gold mining
KW - Mercury
KW - NAG
KW - Occupational exposure
N1 - Accession Number: 16129441; Drake, Pamela L. 1; Email Address: pcd8@cdc.gov; Rojas, Maritza 2; Reh, Christopher M. 3; Mueller, Charles A. 4; Jenkins, F. Michael 1; Affiliations: 1: National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315E. Montgomery, Spokane, WA 99207, USA.; 2: Center for Toxicological Investigations (CITUC) University of Carabobo, Valencia, Venezuela.; 3: National Institute for Occupational Safety and Health, Hazard Evaluation and Technical Assistance Branch, Cincinnati, Ohio, USA.; 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; Issue Info: Mar2001, Vol. 74 Issue 3, p206; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial hygiene; Subject Term: Health education; Subject Term: Urinary organs; Subject Term: Allied health personnel; Subject Term: Public health personnel; Author-Supplied Keyword: Gold mining; Author-Supplied Keyword: Mercury; Author-Supplied Keyword: NAG; Author-Supplied Keyword: Occupational exposure; Number of Pages: 7p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Nelson, B. K.
AU - Snyder, D. L.
AU - Shaw, P. B.
T1 - Developmental Toxicity Interactions of Methanol and Radiofrequency Radiation or 2-Methoxyethanol in Rats.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2001/03//
VL - 20
IS - 2
M3 - Article
SP - 89
EP - 100
PB - Taylor & Francis Ltd
SN - 10915818
AB - This research was undertaken to determine potential interactions among chemical and physical agents. Radiofrequency (RF) radiation is used in numerous workplaces, and many workers are concurrently exposed to RF radiation and various chemicals. The developmental toxicity of RF radiation is associated with the degree and duration of hyperthermia induced by the exposure. Previous animal research indicates that hyperthermia induced by an elevation in ambient temperature can potentiate the toxicity and teratogenicity of some chemical agents. We previously demonstrated that combined exposure to RF radiation (10 MHz) and the industrial solvent, 2-methoxyethanol (2ME), enhanced teratogenicity in rats. Interactions were noted at even the lowest levels of 2ME tested, but only at hyperthermic levels of RF radiation. The purpose of the present research is to investigate if the interactive effects noted for RF radiation and 2ME are unique to these agents, or if similar interactions might be seen with other chemicals. Because methanol is widely used as a solvent as well as fuel additive, and, at high levels, is teratogenic in animals, we selected methanol as a chemical to address generalizability. Based on the literature and our pilot studies, 0, 2, or 3 g/kg methanol (twice, at 6-hour intervals) were administered on gestation day 9 or 13 to groups of 10 Sprague-Dawley rats. Dams treated on day 9 were given methanol and exposed to RF radiation sufficient to maintain colonic temperature at 41 ° C for 60 minutes (or sham). Those treated on day 13 were given methanol plus either 0 or 100 mg/kg 2ME. Because we observed that methanol produced hypothermia, some groups were given the initial dose of methanol concurrently with the RF or 2ME, and others were given the first dose of methanol 1.5 hours prior to RF or 2ME. Dams were sacrificed on gestation day 20, and the fetuses were examined for external malformations. The results indicate that RF radiation or methanol on day 9 increased the incidence of resorbed fetuses, but no interactive effects were observed. The resorptions were highest in groups given the experimental treatments 1.5 hours apart. The higher dose of methanol also reduced fetal weights. Administration of 2ME or methanol on day 13 increased the rate of malformations, and there was evidence of a positive interaction between 2ME and methanol. Fetal weights were reduced by 2ME and methanol alone, but no interaction was observed. Also, separation of the dosing with the teratogens did not affect the results. These results point out that interactions in developmental toxicology, such as those of RF radiation, 2ME, and methanol that we have studied, are complex, and such interactions cannot be fully understood or predicted without more research. It is important that combined exposure effects be considered when developing both physical agent and chemical agent exposure guidelines and intervention strategies. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radiation -- Physiological effect
KW - Methanol
KW - Toxicology
KW - Toxicological interactions
KW - Developmental toxicology
KW - Exposure standards
KW - Glycol ethers
KW - Hyperthermia
KW - INDUSTRIAL SOLVENTS
KW - INTERVENTION STRATEGIES
KW - RF RADIATION
KW - Synergism
N1 - Accession Number: 4437935; Nelson, B. K. 1; Snyder, D. L. 1; Shaw, P. B. 1; Affiliations: 1: National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Mar2001, Vol. 20 Issue 2, p89; Thesaurus Term: Radiation -- Physiological effect; Thesaurus Term: Methanol; Thesaurus Term: Toxicology; Subject Term: Toxicological interactions; Subject Term: Developmental toxicology; Author-Supplied Keyword: Exposure standards; Author-Supplied Keyword: Glycol ethers; Author-Supplied Keyword: Hyperthermia; Author-Supplied Keyword: INDUSTRIAL SOLVENTS; Author-Supplied Keyword: INTERVENTION STRATEGIES; Author-Supplied Keyword: RF RADIATION; Author-Supplied Keyword: Synergism; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/10915810151115218
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 89394416
T1 - Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog.
AU - Royce, Melanie E.
AU - Hoff, Paulo M.
AU - Dumas, Pamela
AU - Lassere, Yvonne
AU - Lee, J. Jack
AU - Coyle, John
AU - Ducharme, Murray P.
AU - De Jager, Robert
AU - Pazdur, Richard
AU - Royce, M E
AU - Hoff, P M
AU - Dumas, P
AU - Lassere, Y
AU - Lee, J J
AU - Coyle, J
AU - Ducharme, M P
AU - De Jager, R
AU - Pazdur, R
Y1 - 2001/03//3/1/2001
N1 - Accession Number: 89394416. Language: English. Entry Date: 20010622. Revision Date: 20161120. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Profile of Mood States (POMS); Longitudinal Interval Follow-Up Evaluation (LIFE). NLM UID: 8309333.
KW - Antineoplastic Agents -- Adverse Effects
KW - Camptothecin -- Adverse Effects
KW - Neoplasms -- Drug Therapy
KW - Dose-Response Relationship, Drug
KW - Aged
KW - Adult
KW - Male
KW - Antineoplastic Agents -- Pharmacokinetics
KW - Camptothecin -- Administration and Dosage
KW - Infusions, Intravenous
KW - Human
KW - Thrombocytopenia -- Chemically Induced
KW - Female
KW - Middle Age
KW - Agranulocytosis -- Chemically Induced
KW - Camptothecin -- Pharmacokinetics
KW - Antineoplastic Agents -- Administration and Dosage
KW - Camptothecin -- Analogs and Derivatives
KW - Clinical Trials
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 1493
EP - 1500
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 5
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - Purpose: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and recommended phase II dose of Exatecan mesylate (DX-8951f) when administered as a 24-hour continuous infusion every 3 weeks to patients with solid tumors.Patients and Methods: Twenty-two patients with advanced solid tumors, all previously treated, and with performance status < or = 2, were entered. The starting dose of DX-8951f was 0.15 mg/m(2); the dose was escalated according to the modified continual reassessment method. The drug was administered until disease progression or until unacceptable toxic effects occurred.Results: Seven dose escalations were completed, and a total of 53 courses were delivered (median, two courses; range, one to eight courses) during the study. At doses 1.2 mg/m(2) and lower, toxicities were mostly grade 1, primarily hematologic. In the initial cohort of three patients treated at 2.4 mg/m(2), grade 2 hematologic toxicity was observed. Of the six additional patients entered at 2.4 mg/m(2), three had grade 3 or 4 granulocytopenia. At doses higher than 2.4 mg/m(2), DLT granulocytopenia was observed. Nonhematologic toxicities, including nausea, vomiting, diarrhea, fatigue, and alopecia, were mild to moderate. Neither complete nor partial responses were observed, but four patients had stable disease. The PK profile of DX-8951f seemed linear at the doses administered. The plasma clearance, total volume of distribution, and terminal elimination half-life were approximately 3 L/h, 40 L, and 14 hours, respectively.Conclusion: The DLT of this DX-8951f schedule was granulocytopenia for minimally pretreated patients, and both granulocytopenia and thrombocytopenia for heavily pretreated patients. The MTD for both minimally and heavily pretreated patients was 2.4 mg/m(2). DX-8951f seems to have a linear PK profile on the basis of single-dose administration. The recommended phase II dose with this schedule is 2.4 mg/m(2) for minimally pretreated patients. A lower dose should be used for heavily pretreated patients.
SN - 0732-183X
AD - University of Texas M.D. Anderson Cancer Center, Houston, TX
AD - Daiichi Pharmaceutical Corporation, Montvale, NJ
AD - Phoenix International Life Sciences, Montreal, Canada
AD - United States Food and Drug Administration, Rockville, MD
AD - University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
U2 - PMID: 11230496.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Machlin, Steven R.
AU - Valluzzi, Janet L.
AU - Chevarley, Frances M.
AU - Thorpe, Joshua M.
T1 - Measuring ambulatory health care use in the United States: A comparison of 1996 estimates across four federal surveys.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2001/03//
VL - 27
IS - 1/2
M3 - Article
SP - 57
EP - 69
PB - IOS Press
SN - 07479662
AB - The US Department of Health and Human Services currently sponsors a number of national surveys that have different primary objectives and methodologies, but all can be used in different ways to produce general estimates of the use of ambulatory care in the United States. Among these surveys are the Medical Expenditure Panel Survey (MEPS), National Health Interview Survey (NHIS), National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS). Through a comparison of 1996 survey estimates, this paper describes important methodological considerations when using these different data sources for measuring ambulatory use. This paper complements a previous article comparing estimates of hospital inpatient utilization across several federal data sources. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - SOCIAL sciences -- Methodology
KW - OUTPATIENT medical care
KW - INPATIENT care
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 8565309; Machlin, Steven R. 1; Email Address: smachlin@ahrq.gov; Valluzzi, Janet L. 1; Chevarley, Frances M. 1; Thorpe, Joshua M. 2; Affiliations: 1: Agency for Healthcare Research and Quality (AHRQ), Rockville, MD 20852, USA; 2: University of North Carolina, Chapel Hill, USA; Issue Info: 2001, Vol. 27 Issue 1/2, p57; Subject Term: HEALTH surveys; Subject Term: SOCIAL sciences -- Methodology; Subject Term: OUTPATIENT medical care; Subject Term: INPATIENT care ; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Thomas, Kathleen C.
AU - Snowden, Lonnie R.
AD - Cecil G Sheps Center for Heath Services Research, U NC
AD - Center for Mental Health Services Research, U CA, Berkeley
T1 - Minority Response to Health Insurance Coverage for Mental Health Services
JO - Journal of Mental Health Policy and Economics
JF - Journal of Mental Health Policy and Economics
Y1 - 2001/03//
VL - 4
IS - 1
SP - 35
EP - 41
SN - 10914358
N1 - Accession Number: 0627455; Keywords: Health Insurance; Health; Insurance; Outpatient; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200211
N2 - The present study sought to determine if public insurance is as effective in promoting outpatient mental health treatment as private coverage for ethnic minority groups.
KW - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination J15
KW - Analysis of Health Care Markets I11
KW - Insurance; Insurance Companies; Actuarial Studies G22
L3 - http://www.icmpe.org/test1/journal/journal.htm
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UR - http://www.icmpe.org/test1/journal/journal.htm
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 107011903
T1 - Device safety. Central venous catheters and cardiac tamponade.
AU - Blum DY
Y1 - 2001/03//
N1 - Accession Number: 107011903. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Central Venous Catheters -- Adverse Effects -- In Infancy and Childhood
KW - Cardiac Tamponade -- Etiology -- In Infancy and Childhood
KW - Infant, Newborn
KW - Inpatients
SP - 30
EP - 30
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Senior Nurse Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
U2 - PMID: 11288546.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106889634
T1 - Theme 1. Disaster coordination and management: summary and action plans...5th Asia-Pacific Conference on Disaster Medicine
AU - der Heide EA
AU - Lafond R
AU - Fertel N
AU - Fisher JM
AU - Hampton D
AU - Lederman B
AU - Posner Z
AU - Preobrajensky VN
AU - Rebonato M
AU - Riboni V
AU - Rodriguez D
AU - Shih C
AU - Yamamoto Y
Y1 - 2001/03//03/01/2001
N1 - Accession Number: 106889634. Language: English. Entry Date: 20020104. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8918173.
KW - Disaster Planning
KW - Emergency Medicine
SP - 22
EP - 25
JO - Prehospital & Disaster Medicine
JF - Prehospital & Disaster Medicine
JA - PREHOSPITAL DISASTER MED
VL - 16
IS - 1
PB - Cambridge University Press
AB - INTRODUCTION: Disaster is a collective responsibility requiring coordinated response from all parts of society. This theme focused on coordination and management issues in a diverse range of scenarios. METHODS: Details of the methods used are provided in the preceding paper. The chairs moderated all presentations and produced a summary that was presented to an assembly of all of the delegates. Although the main points developed in Themes 1 and 4 were different from each other (as reported in the Results section), their implementation was similar. Therefore, the chairs of both groups presided over one workshop that resulted in the generation of a set of Action Plans that then were reported to the collective group of all delegates. RESULTS: The main points developed during the presentations and discussions included: (1) the need for evidence-based assessments and planning, (2) the need for a shift in focus to health-sector readiness, (3) empowerment of survivors, (4) provision of relief for the caregivers, (5) address the incentives and disincentives to attain readiness, (6) engage in joint preparation, response, and training, (7) focus on prevention and mitigation of the damage from events, and (8) improve media relations. There exists a need for institutionalization of processes for learning from experiences obtained from disasters. DISCUSSION: Action plans presented include: (1) creation of an Information and Data Clearinghouse on Disaster Management, (2) identification of incentives and disincentives for readiness and develop strategies and interventions, and (3) act on lessons learned from evidence-based research and practical experience. CONCLUSIONS: There is an urgent need to proactively establish coordination and management procedures in advance of any crisis. A number of important insights for improvement in coordination and management during disasters emerged.
SN - 1049-023X
AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Washington, DC
U2 - PMID: 11367933.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jason, J.
AU - Inge, K. L.
T1 - Modulation of CD8 and CD3 by HIV or HIV Antigens.
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
Y1 - 2001/03//
VL - 53
IS - 3
M3 - Article
SP - 259
EP - 267
SN - 03009475
AB - To investigate whether human immunodeficiency virus (HIV)-1 and HIV-1 antigens modulate surface and cytoplasmic CD8 or CD3, as well as CD4, we used cell permeabilization reagents, surface/cytoplasmic fluorescent staining, multiparameter flow cytometric techniques and an in vitro culture system in which relatively few lymphocytes are actively infected with HIV. Human peripheral blood lymphocytes were: not stimulated, not stimulated but HIV-inoculated, phytohaemagglutinin (PHA)-stimulated, PHA/HIV-inoculated (PHA/HIV), or placed into media with soluble gp120, Rev or Nef. HIV inoculation and Nef had striking modulatory effects on CD8. The cytoplasmic CD8 median fluorescent intensity (MFI) of positive lymphocytes was lower for cells in unstimulated/HIV-infected cultures than unstimulated cultures (44 versus 62% of ex vivo value, P = 0.032) and lower for cells in PHA/HIV cultures than in PHA cultures (56 versus 100% of ex vivo, P = 0.041). The surface CD8 MFI values for Nef were significantly lower than the ex vivo value (75% of ex vivo, P = 0.006). At days 2–7 of culture, Rev was associated with slight reductions in surface CD4 MFI (58% of ex vivo versus 78% of ex vivo for unstimulated cultures, P = 0.047) and greater effects on cytoplasmic CD3 MFI (131 versus 179% of ex vivo for unstimulated cultures, P = 0.035), and surface CD8 MFI (70% of ex vivo, P = 0.006 versus ex vivo value). The globality of Rev's effects suggests these are related to a shared processing pathway, i.e. not due to direct interaction with CD3, CD4 and CD8; the effects of HIV inoculation and Nef on CD8 expression appear to be more CD8 specific. Because CD8 is essential for cytotoxic T-cell function, its down-modulation could inhibit this activity, including anti-HIV cytotoxicity. Given the critical roles of CD3 and CD8 in T-lymphocyte signal transduction and antigen responsiveness, the effects of HIV, Rev and Nef on these molecules have clinically significant implications concerning the pathogenesis and treatment of HIV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CD antigens
KW - HIV (Viruses)
KW - CYTOPLASM
KW - LYMPHOCYTES
N1 - Accession Number: 5509052; Jason, J. 1; Inge, K. L. 1; Source Information: Mar2001, Vol. 53 Issue 3, p259; Subject: CD antigens; Subject: HIV (Viruses); Subject: CYTOPLASM; Subject: LYMPHOCYTES; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-3083.2001.00871.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Tor-Agbidye, John
AU - Yamamoto, Bryan
AU - Bowyer, John F.
T1 - Seizure Activity and Hyperthermia Potentiate the Increases in Dopamine and Serotonin Extracellular Levels in the Amygdala during Exposure to d-Amphetamine.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/03//
VL - 60
IS - 1
M3 - Article
SP - 103
EP - 111
PB - Oxford University Press / USA
SN - 10966080
AB - Behavioral stereotypy, hyperthermia, and convulsive activity produced by exposure to multiple doses of d-amphetamine (AMPH) were related to changes in the extracellular levels of dopamine and serotonin (5-HT) in the amygdala, using the technique of microdialysis in awake and freely moving rats. Hyperactivity and stereotypy, as well as increases in microdialysis dopamine levels ranging from 100–300% of pre-AMPH basal microdialysate levels (BL), occurred during exposure to 3 doses of 2.5 mg/kg (3 × 2.5 mg/kg) AMPH. Three doses of 5 mg/kg produced a more intense stereotypic behavior as well as hyperthermia, and resulted in large increases in the peak dopamine levels (700% BL) while 5-HT levels were increased to a lesser extent (300% BL). The highest doses tested of 3 × 15 mg/kg produced convulsive activity, seizures, intense stereotypy and hyperthermia with peak microdialysate dopamine (1300% BL) and 5-HT levels (1800% BL) that were 2-fold and 6-fold greater, respectively, than those at the 3 × 5-mg/kg doses. Microdialysate glutamate levels were not changed by AMPH exposure. Rats that did not become hyperthermic when dosed with 15 mg/kg AMPH in a cold environment (10°C) exhibited some hyperactivity and stereotypic behavior, but not overt convulsive behavior. Dopamine and 5-HT levels in these rats were significantly reduced by about 75% and 60%, respectively, compared to the room-temperature group. Inclusion of 2 μM tetrodotoxin (TTX) in the microdialysis buffer significantly reduced the 15-mg/kg AMPH-induced increases in dopamine by 30% and the increase in 5-HT levels by 70% at room temperature. These results indicate that a smaller portion of the dopamine release evoked by doses of AMPH that induce seizure activity is neuronal impulse-dependent while the majority of 5-HT released is impulse-dependent. Irrespective of impulse activity, the hyperthermia alone markedly potentiated dopamine release but had a lesser effect on 5-HT release. Thus, there are differences in the regulation of dopamine and serotonin release in the amygdala from high doses of AMPH, which are known to produce neurotoxicity. Further studies are necessary to determine the impact of these differences in release on AMPH neurotoxicity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Amphetamines
KW - Fever
KW - Dopamine
KW - Serotonin
KW - Amygdaloid body
KW - Brain microdialysis
KW - amphetamine
KW - amygdala
KW - dopamine
KW - neurotoxicity
KW - seizures
KW - serotonin
N1 - Accession Number: 44406106; Tor-Agbidye, John 1; Yamamoto, Bryan 2; Bowyer, John F. 1; Email Address: jbowyer@nctr.fda.gov; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; 2: Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio 44106; Issue Info: Mar2001, Vol. 60 Issue 1, p103; Thesaurus Term: Amphetamines; Subject Term: Fever; Subject Term: Dopamine; Subject Term: Serotonin; Subject Term: Amygdaloid body; Subject Term: Brain microdialysis; Author-Supplied Keyword: amphetamine; Author-Supplied Keyword: amygdala; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: seizures; Author-Supplied Keyword: serotonin; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Faroon, Obaid M
AU - Keith, Sam
AU - Jones, Dennis
AU - de Rosa, Christopher
T1 - Carcinogenic effects of polychlorinated biphenyls.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/03//
VL - 17
IS - 2
M3 - Article
SP - 41
EP - 62
PB - Sage Publications, Ltd.
SN - 07482337
AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of an important section of the Toxicological profile for polychlorinated biphenyls [ATSDR. 2000: Toxicological profile for polychlorinated biphenyls. Atlanta, GA: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry.] into the scientific literature. This article focuses on the carcinogenic effects of this group of synthetic organic chemicals (polychlorinated biphenyls) in humans and animals. Information on other health effects, toxicokinetics, mechanisms of toxicity, biomarkers, interactions, chemical and physical properties, potential for human exposure, and regulations and advisories is detailed in the profile. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biphenyl compounds
KW - Cancer
KW - Biliary tract cancer
KW - BREAST CANCER
KW - CANCER
KW - Congener
KW - Liver cancer
KW - MIXTURES
KW - Non-Hodgkin's lymphoma
KW - PCBS
KW - Skin cancer
N1 - Accession Number: 6943009; Faroon, Obaid M 1; Keith, Sam 1; Jones, Dennis 1; de Rosa, Christopher 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA; Issue Info: 2001, Vol. 17 Issue 2, p41; Thesaurus Term: Biphenyl compounds; Subject Term: Cancer; Author-Supplied Keyword: Biliary tract cancer; Author-Supplied Keyword: BREAST CANCER; Author-Supplied Keyword: CANCER; Author-Supplied Keyword: Congener; Author-Supplied Keyword: Liver cancer; Author-Supplied Keyword: MIXTURES; Author-Supplied Keyword: Non-Hodgkin's lymphoma; Author-Supplied Keyword: PCBS; Author-Supplied Keyword: Skin cancer; Number of Pages: 22p; Document Type: Article
L3 - 10.1191/0748233701th098oa
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Darby, Charles
T1 - Commentary.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2001/03/02/Supplement 1
VL - 58
IS - S1
M3 - Article
SP - 67
EP - 69
SN - 10775587
N1 - Accession Number: 54898134; Darby, Charles 1; Source Information: Supplement 1, Vol. 58 Issue S1, p67; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1192
L3 - 10.1177/107755870105800108
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Schwetz, Bernard A.
AU - Schwetz, B A
T1 - From the Food and Drug Administration.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2001/03/07/
VL - 285
IS - 9
M3 - journal article
SP - 1146
EP - 1146
SN - 00987484
AB - Presents medical news briefs from the United States Food and Drug Administration. Development of a revised informed consent form and medication guide to strengthen protection for patients who use isotretinoin (Accutane); Approval of an indication for letrozole as a first-line treatment for post-menopausal women with hormone receptor-positive or breast cancer; Approval of mesalamine rectal suppositories; Others.
KW - UNITED States. Food & Drug Administration
KW - ISOTRETINOIN
KW - BREAST cancer -- Treatment
KW - SUPPOSITORIES
KW - ANTINEOPLASTIC agents -- Therapeutic use
KW - HETEROCYCLIC compounds -- Therapeutic use
KW - ORGANIC compounds -- Therapeutic use
KW - BREAST tumors
KW - CLINICAL trials
KW - DERMATOLOGIC agents
KW - INFORMATION services
KW - NONSTEROIDAL anti-inflammatory agents
KW - ULCERATIVE colitis
KW - RELATIVE risk (Medicine)
KW - MESALAMINE
KW - UNITED States
N1 - Accession Number: 4166011; Schwetz, Bernard A.; Schwetz, B A 1; Source Information: 3/7/2001, Vol. 285 Issue 9, p1146; Subject: UNITED States. Food & Drug Administration; Subject: ISOTRETINOIN; Subject: BREAST cancer -- Treatment; Subject: SUPPOSITORIES; Subject: ANTINEOPLASTIC agents -- Therapeutic use; Subject: HETEROCYCLIC compounds -- Therapeutic use; Subject: ORGANIC compounds -- Therapeutic use; Subject: BREAST tumors; Subject: CLINICAL trials; Subject: DERMATOLOGIC agents; Subject: INFORMATION services; Subject: NONSTEROIDAL anti-inflammatory agents; Subject: ULCERATIVE colitis; Subject: RELATIVE risk (Medicine); Subject: MESALAMINE; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106968166
T1 - Histamine poisoning associated with eating tuna burgers.
AU - Becker K
AU - Southwick K
AU - Reardon J
AU - Berg R
AU - MacCormack JN
AU - Becker, K
AU - Southwick, K
AU - Reardon, J
AU - Berg, R
AU - MacCormack, J N
Y1 - 2001/03/14/
N1 - Accession Number: 106968166. Language: English. Entry Date: 20021011. Revision Date: 20161112. Publication Type: journal article; CEU; research; tables/charts. Commentary: Su M, Nelson L S. Histamine poisoning from seafood. (JAMA) 6/21/2001; 285 (23): 2977-2978. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Food Contamination
KW - Histamine -- Poisoning
KW - Food Poisoning -- Epidemiology
KW - Fish -- Poisoning
KW - Food Services
KW - North Carolina
KW - Food Poisoning -- Risk Factors
KW - Food Microbiology
KW - Food Handling
KW - Record Review
KW - United States Food and Drug Administration
KW - Food Poisoning -- Prevention and Control
KW - Disease Outbreaks
KW - Food Preservation
KW - Education, Continuing (Credit)
KW - Human
SP - 1327
EP - 1374
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 285
IS - 10
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Histamine poisoning occurs when persons ingest fish in which bacteria have converted histidine to histamine, a process that usually can be controlled by storage at low temperatures. From 1994 to 1997, North Carolina averaged 2 cases annually; however, from July 1998 to February 1999, a total of 22 cases of histamine fish poisoning were reported.Objectives: To examine the increase in histamine case reports, identify risk factors for poisoning, and develop recommendations for prevention.Design and Setting: Case series evaluated in North Carolina from July 1998 to February 1999.Subjects: Reported case-patients with 2 of the following symptoms within 2 hours of eating tuna: rash, facial flushing, vomiting, diarrhea, dyspnea, a tight feeling in the throat, headache, or a metallic or peppery taste in the mouth.Results: Twenty cases occurred during 5 outbreaks, and there were 2 single occurrences. Of the 22 persons affected, 19 (86%) sought emergency medical care. All case-patients ate tuna: 18 ate tuna burgers, 2 ate salad containing tuna, and 2 ate filets. Tuna samples (available from 3 outbreaks) had histamine levels above the Food and Drug Administration regulatory level of 50 ppm (levels were between 213 and 3245 ppm). In 19 cases, the tuna used to prepare burgers or salads was frozen and thawed more than once before serving. Violations of recommended temperature controls were identified in 2 of the 5 restaurants, accounting for 14 (64%) cases.Conclusions: Tuna burgers, a relatively new menu item in restaurants, were associated with an increase in histamine poisoning cases in North Carolina. Tuna ground for burgers can be susceptible to both temperature fluctuations and bacterial contamination.
SN - 0098-7484
AD - Office of International and Refugee Health, US Department of Health and Human Services, 5600 Fishers Ln, Parklawn Bldg, Room 18-105, Rockville, MD 20857, USA
AD - Centers for Disease Control and Prevention, Raleigh, NC; kbecker@osophis.dhhs.gov
U2 - PMID: 11255388.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hines, Cynthia J.
AU - Deddens, James A.
AU - Tucker, Samuel P.
AU - Hornung, Richard W.
T1 - Distributions and determinants of pre-emergent herbicide exposures among custom applicators.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2001/04//
VL - 45
IS - 3
M3 - Article
SP - 227
EP - 239
SN - 00034878
AB - Custom applicators intensively apply herbicides to corn and soybean fields each spring. The primary objective of this study was to characterize the exposure distributions of the herbicides alachlor, atrazine, 2,4-D 2-ethylhexyl ester (2,4-D EH), and metolachlor among a group of applicators during the spring pre-emergent spray season. A secondary objective was to evaluate determinants of exposure and to estimate within- and between-worker variance components. Fifteen applicators were sampled using a systematic design that included spray and non-spray days and multiple measurements (five to seven) on each applicator. Air, patch, and handwash samples were collected on 89 applicator-days. Applicator-days were classified into three categories: target herbicide sprayed, non-target herbicide sprayed, and no herbicide sprayed. Mixed-model regression analysis was used. For all exposure metrics, adjusted mean herbicide exposures were significantly higher on days when target herbicides were sprayed as compared to non-spray days. For 2,4-D EH only, adjusted mean exposures on non-target herbicide spray days were significantly higher than on non-spray days. Wearing gloves significantly reduced adjusted mean hand exposure for all herbicides (4–20 fold) and adjusted mean thigh exposure for three herbicides (8–53 fold) on days the herbicides were sprayed; however, wearing gloves significantly increased adjusted mean atrazine hand and thigh exposures (9 and 7 fold, respectively) on days that non-atrazine herbicides were sprayed. Few of the other covariates were consistent determinants of exposure. For all exposure metrics, the within-worker variability (GSDW 2.1–5.6) was greater than the between-worker variability (GSDB 1.2–2.7). [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Herbicides
KW - Alachlor
KW - Atrazine
KW - Hazardous substances
KW - Occupational hazards
KW - Industrial hygiene
KW - Metolachlor
KW - Ethylhexyl acrylate
KW - Regression analysis
KW - 2
KW - 2;4-D
KW - 4-D
KW - alachlor
KW - atrazine
KW - determinants of exposure
KW - exposure assessment
KW - metolachlor
KW - mixed-models
KW - variance components
N1 - Accession Number: 44400121; Hines, Cynthia J. 1; Email Address: cjh8@cdc.gov; Deddens, James A. 1,2; Tucker, Samuel P. 1; Hornung, Richard W. 3; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; 2: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221, USA; 3: Institute for Health Policy and Health Services Research, University of Cincinnati, Cincinnati, OH 45267, USA; Issue Info: Apr2001, Vol. 45 Issue 3, p227; Thesaurus Term: Herbicides; Thesaurus Term: Alachlor; Thesaurus Term: Atrazine; Thesaurus Term: Hazardous substances; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial hygiene; Subject Term: Metolachlor; Subject Term: Ethylhexyl acrylate; Subject Term: Regression analysis; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2;4-D; Author-Supplied Keyword: 4-D; Author-Supplied Keyword: alachlor; Author-Supplied Keyword: atrazine; Author-Supplied Keyword: determinants of exposure; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: metolachlor; Author-Supplied Keyword: mixed-models; Author-Supplied Keyword: variance components; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 13p; Illustrations: 10 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106705248
T1 - Disaster prevention: lessons learned from the Titanic.
AU - Battles JB
Y1 - 2001/04//2001 Apr
N1 - Accession Number: 106705248. Language: English. Entry Date: 20040220. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9302033.
KW - Disasters -- Analysis
KW - Root Cause Analysis
KW - Ships
KW - Treatment Errors -- Prevention and Control
SP - 150
EP - 153
JO - Baylor University Medical Center Proceedings
JF - Baylor University Medical Center Proceedings
JA - BAYLOR UNIV MED CENT PROC
VL - 14
IS - 2
CY - Dallas, Texas
PB - Baylor University Medical Center
SN - 0899-8280
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 2101 E Jefferson Street Suite 502, Rockville, MD 20852; jbattles@ahrq.gov
U2 - PMID: 16369606.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Neriishi, K.
AU - Nakashima, E.
AU - Delongchamp, R. R.
T1 - Persistent subclinical inflammation among A-bomb survivors.
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
Y1 - 2001/04//
VL - 77
IS - 4
M3 - Article
SP - 475
EP - 482
PB - Taylor & Francis Ltd
SN - 09553002
AB - Purpose: To investigate the associations between inflammation tests and radiation dose in A-bomb survivors. Subjects and methods: Subjects were A-bomb survivors who underwent inflammation tests of leukocyte counts, neutrophil counts, erythrocyte sedimentation rate, corrected erythrocyte sedimentation rate, α-1 globulin, α-2 globulin and sialic acid between 1988 and 1992. Associations with radiation dose (DS86) were analyzed by regression analysis and heterogeneity among inflammatory diseases, anaemia at examination, or history of cancer was also tested. Results: The associations with radiation dose were statistically significant for leukocyte counts (71.0mm[sup -3] Gy[sup -1], p=0.015), erythrocyte sedimentation rate (1.58mm h[sup -1] Gy[sup -1], p=0.0001), corrected erythrocyte sedimentation rate (1.14 mm h[sup -1] Gy[sup -1], p=0.0001), α-1 globulin (0.0057 g dl[sup -1] Gy[sup -1], p=0.0001), α-2 globulin (0.0128 g dl[sup -1] Gy[sup -1], p=0.0001), and sialic acid (1.2711 mg dl[sup -1] Gy[sup -1], p=0.0001) but not for neutrophil counts (29.9mm[sup -3] Gy[sup -1], p=0.17). Heterogeneity was not statistically significant. Among inflammatory diseases, associations were the strongest for chronic thyroiditis and chronic liver diseases. Conclusions: This study suggests statistically significant association between inflammation in A-bomb survivors and radiation dose of during 1988-1992. The association might contribute, as an epigenetic and/or bystander effect, to development of several radiation-induced disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Radiation Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATOMIC bomb
KW - INFLAMMATION
KW - RADIATION carcinogenesis
KW - JAPAN
N1 - Accession Number: 5171945; Neriishi, K. 1; Nakashima, E. 2; Delongchamp, R. R. 3; Source Information: Apr2001, Vol. 77 Issue 4, p475; Subject: ATOMIC bomb; Subject: INFLAMMATION; Subject: RADIATION carcinogenesis; Geographic Terms: JAPAN; Number of Pages: 8p; Illustrations: 5 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/09553000010024911
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107075831
T1 - From the Food and Drug Administration. Medical device adverse events and the temporary invasive cardiac pacemaker.
AU - Dwyer D
Y1 - 2001/04//2001 Apr-Jun
N1 - Accession Number: 107075831. Language: English. Entry Date: 20011214. Revision Date: 20150820. Publication Type: Journal Article; case study; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Mandatory Reporting
KW - Pacemaker, Artificial -- Adverse Effects
KW - United States Food and Drug Administration
KW - Nursing Role
KW - Pacemaker, Artificial -- Utilization
KW - World Wide Web
KW - Information Resources
SP - 70
EP - 73
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 7
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Nurse Consultant, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr, Rockville, MD 20850. E-mail: ded@cdrh.fda.gov
U2 - PMID: 11313630.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106987600
T1 - Adapting the HCUP QIs for hospital use: the experience in New York State...Healthcare Cost and Utilization Project
AU - Jiang HJ
AU - Ciccone K
AU - Urlaub CJ
AU - Boyd D
AU - Meeks G
AU - Horton L
Y1 - 2001/04//2001 Apr
N1 - Accession Number: 106987600. Language: English. Entry Date: 20021213. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9315239.
KW - Clinical Indicators
KW - Quality of Health Care
KW - Hospitals -- New York
KW - Benchmarking
KW - United States Agency for Healthcare Research and Quality
KW - Quality Improvement
KW - Productivity
KW - Outcomes (Health Care)
KW - Health Resource Utilization
KW - Health Services Accessibility
KW - Software
KW - Risk Assessment
KW - Data Collection
KW - Reports
KW - International Classification of Diseases
KW - Health Care Costs
KW - Multiinstitutional Systems
KW - New York
KW - Inpatients
SP - 200
EP - 215
JO - Joint Commission Journal on Quality Improvement
JF - Joint Commission Journal on Quality Improvement
JA - JOINT COMM J QUAL IMPROV
VL - 27
IS - 4
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1070-3241
AD - Social Scientist, Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 11293837.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Castelo, M. M.
AU - Jackson, L. S.
AU - Hanna, M. A.
AU - Reynolds, B. H.
AU - Bullerman, L. B.
T1 - Loss of Fuminosin B1 in Extruded and Baked Corn-Based Foods with Sugars.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2001/04//
VL - 66
IS - 3
M3 - Article
SP - 416
EP - 421
SN - 00221147
AB - The objective of this work was to determine the effect of added sugars on fumonisin B1 (F1) levels in baked corn muffins and extruded corn grits. Muffins containing added glucose had significantly lower F1 levels than muffins with sucrose, fructose, or no added sugar. Extrusion cooking of the grits resulted in significant (p<0.05) reductions of FB1 in all treatments relative to unextruded controls, but use of glucose resulted in greater reductions of FB1 (45.3 to 71%) than did the use of fructose (29.5 to 53%) or sucrose (19.2 to 39%). When extrusion conditions were optimized, 92.1% loss of FB1 was found when grits were extruded with glucose. Adding glucose to thermally processed food can result in a substantial reduction in FB1 levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Corn
KW - Sugars
KW - Fumonisins
KW - Glucose
KW - Baked products
KW - Fructose
KW - Sucrose
KW - corn
KW - extrusion
KW - fumonisin
KW - glucose
N1 - Accession Number: 28655987; Castelo, M. M. 1; Jackson, L. S. 2; Hanna, M. A. 3; Reynolds, B. H. 4; Bullerman, L. B. 5; Email Address: lbullerman1@unl.edu; Affiliations: 1: Lopez Foods, Inc., 9500 NW 4th St., Oklahoma City, Okla.; 2: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Ill.; 3: Deparment of Biological System Engineering, University of Nebraska-Lincoln, Lincoln, Ne.; 4: National Center for Food Safety and Technology, Illinois Institute of Technology, Summit-Argo, Ill.; 5: Dept. of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Ne.; Issue Info: Apr2001, Vol. 66 Issue 3, p416; Thesaurus Term: Corn; Subject Term: Sugars; Subject Term: Fumonisins; Subject Term: Glucose; Subject Term: Baked products; Subject Term: Fructose; Subject Term: Sucrose; Author-Supplied Keyword: corn; Author-Supplied Keyword: extrusion; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: glucose; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 445291 Baked Goods Stores; NAICS/Industry Codes: 311821 Cookie and Cracker Manufacturing; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 311813 Frozen Cakes, Pies, and Other Pastries Manufacturing; NAICS/Industry Codes: 311812 Commercial Bakeries; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111150 Corn Farming; Number of Pages: 6p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106950445
T1 - What does evidence mean? Can the law and medicine be reconciled?
AU - Eisenberg JM
Y1 - 2001/04//
N1 - Accession Number: 106950445. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; legal case. Commentary: Mello MM, Brennan TA. Demystifying the law/science disconnect. (J HEALTH POLIT POLICY LAW) Apr2001; 26 (2): 429-438. Journal Subset: Health Services Administration; Peer Reviewed; USA. Legal Case: Daubert v. Merrell Dow Pharmaceuticals (509 U.S. 579, 113 S. Ct. 2786 [1993]); Kumho Tire Co. v. Carmichael (131 F.3d 1433 [11th Cir. 1997], reversed, 526 U.S. 137 [1999]). NLM UID: 7609331.
KW - Medical Practice, Evidence-Based -- Legislation and Jurisprudence -- United States
KW - Decision Making, Clinical -- Methods
KW - Legal Procedure -- Standards
KW - Health Care Delivery -- Legislation and Jurisprudence -- United States
KW - Evidence, Legal -- Utilization
KW - United States
KW - Physician Attitudes
KW - Education, Medical
KW - United States Agency for Healthcare Research and Quality
KW - Research, Medical -- Standards
KW - Evidence, Legal -- Classification
KW - Health Policy
SP - 369
EP - 381
JO - Journal of Health Politics, Policy & Law
JF - Journal of Health Politics, Policy & Law
JA - J HEALTH POLIT POLICY LAW
VL - 26
IS - 2
CY - Durham, North Carolina
PB - Duke University Press
SN - 0361-6878
AD - Agency for Healthcare Research and Quality
U2 - PMID: 11330084.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106952050
T1 - Leukemia mortality among radiation-exposed workers.
AU - Schubauer-Berigan MK
AU - Wenzl TB
Y1 - 2001/04//2001 Apr-Jun
N1 - Accession Number: 106952050. Language: English. Entry Date: 20020823. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Occupational Exposure
KW - Leukemia -- Mortality
KW - Radiation Injuries
KW - Radiation, Ionizing -- Adverse Effects
KW - Epidemiological Research
SP - 271
EP - 287
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 16
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - The qualitative leukemogenicity of ionizing radiation was firmly established by studies of medical workers and patients exposed to high radiation levels in the mid-1900s. Quantitative relationships were evaluated through extensive studies of atomic bomb survivors and patients who received therapeutic radiation, for whom the duration of exposure was brief. Although many studies have been conducted of nuclear workers and others exposed occupationally, uncertainty remains about quantitative aspects of the leukemia-radiation exposure relation for low dose-rate, fractionated exposures. Some studies have shown dose-related increases in leukemia risks for certain nuclear workers in the U.S. and Europe, although these findings are inconsistent across populations. Despite limitations in low-dose epidemiology, well-designed studies among nuclear workers should inform some controversial aspects of the relation between ionizing radiation exposure and leukemia risk.
SN - 0885-114X
AD - Health-Related Energy Research Branch, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, MS-R44, Cincinnati, OH 45226
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107044360
T1 - Skills workshop. Diagnosis and management of stable angina in women.
AU - Gonsalves SG
A2 - Hines SE
Y1 - 2001/04//
N1 - Accession Number: 107044360. Language: English. Entry Date: 20010817. Revision Date: 20150820. Publication Type: Journal Article; tables/charts; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 100886269.
KW - Angina, Stable -- Drug Therapy
KW - Angina, Stable -- Diagnosis
KW - Diagnosis, Differential
KW - Checklists
KW - World Wide Web
KW - Information Resources
KW - Electrocardiography
KW - Hematologic Tests
KW - Angina, Stable -- Therapy
KW - Sex Factors
KW - Hormone Replacement Therapy
KW - Chest Pain -- Diagnosis
KW - Female
SP - 13
EP - 22
JO - Patient Care for the Nurse Practitioner
JF - Patient Care for the Nurse Practitioner
JA - PATIENT CARE NURSE PRACT
VL - 4
IS - 4
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
SN - 1524-4083
AD - Family Nurse Practitioner, Public Health Service, Division of Immigration Health Services, INS Medical Facility, New York, NY
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Luster, Michael I.
T1 - Ozone-Induced Mucous Cell Metaplasia.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/04//
VL - 60
IS - 2
M3 - Article
SP - 193
EP - 193
PB - Oxford University Press / USA
SN - 10966080
AB - The article highlighted in this issue is “Endotoxin Enhancement of Ozone-Induced Mucous Cell Metaplasia Is Neutrophil-Dependent in Rat Nasal Epithelium,” by James G. Wagner, Steven J. Van Dyken, Jon A. Hotchkiss, and Jack R. Harkema (pp. 338–347). [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endotoxins
KW - Ozone -- Physiological effect
KW - Metaplasia
KW - Neutrophils
KW - Epithelium
KW - Rats as laboratory animals
N1 - Accession Number: 44406115; Luster, Michael I. 1; Email Address: mluster@cdc.gov; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Issue Info: Apr2001, Vol. 60 Issue 2, p193; Thesaurus Term: Endotoxins; Thesaurus Term: Ozone -- Physiological effect; Thesaurus Term: Metaplasia; Subject Term: Neutrophils; Subject Term: Epithelium; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - O'Brien, Michelle L.
AU - Twaroski, Timothy P.
AU - Cunningham, Michael L.
AU - Glauert, Howard P.
AU - Spear, Brett T.
T1 - Effects of Peroxisome Proliferators on Antioxidant Enzymes and Antioxidant Vitamins in Rats and Hamsters.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/04//
VL - 60
IS - 2
M3 - Article
SP - 271
EP - 278
PB - Oxford University Press / USA
SN - 10966080
AB - Peroxisome proliferators (PPs) cause hepatomegaly, peroxisome proliferation, and hepatocarcinogenesis in rats and mice, whereas hamsters are less responsive to PPs. PPs increase the activities of enzymes involved in peroxisomal β-oxidation and ω-hydroxylation of fatty acids, which has been hypothesized to result in oxidative stress. The hypothesis of this study was that differential modulation of antioxidant enzymes and vitamins might account for differences in species susceptibility to PPs. Accordingly, we measured the activities of DT-diaphorase and superoxide dismutase (SOD) and the hepatic content of ascorbic acid and α-tocopherol in male Sprague-Dawley rats and Syrian hamsters fed 2 doses of 3 known peroxisome proliferators (dibutyl phthalate [DBP], gemfibrozil, and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) for 6, 34, or 90 days. In untreated animals, the activity of DT-diaphorase was much higher in hamsters than in rats, but the control levels of SOD, ascorbic acid and α-tocopherol were similar. In rats and hamsters treated with Wy-14,643, we observed decreases in α-tocopherol content and total SOD activity. DT-diaphorase was decreased in activity following Wy-14,643 treatment in rats at all time points and doses, but only sporadically affected in hamsters. Rats and hamsters treated with DBP demonstrated increased SOD activity at 6 days; however, in the rat, DBP decreased SOD activity at 90 days and α-tocopherol content was decreased throughout. In gemfibrozil treated rats and hamsters, a decrease in α-tocopherol content and an increase in DT-diaphorase activity were observed. In either species, no consistent trend was observed in total ascorbic acid content after treatment with any of the PPs. In conclusion, these data suggest that both rats and hamsters are compromised in antioxidant capabilities following PP treatment and additional hypotheses for species susceptibility should be considered. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Dibutyl phthalate
KW - Peroxisomes
KW - Superoxide dismutase
KW - Vitamin E
KW - Vitamin C
KW - α-tocopherol
KW - α-tocopherol
KW - 643
KW - ascorbic acid
KW - dibutyl phthalate
KW - DT-diaphorase
KW - gemfibrozil
KW - peroxisome proliferator (PP)
KW - Sprague-Dawley rat
KW - superoxide dismutase
KW - Syrian hamster
KW - Wy-14
KW - Wy-14,643
N1 - Accession Number: 44406121; O'Brien, Michelle L. 1,2; Twaroski, Timothy P. 1,3; Cunningham, Michael L. 4; Glauert, Howard P. 1,5; Spear, Brett T. 6; Email Address: bspear@pop.uky.edu; Affiliations: 1: Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536; 2: U.S. Food and Drug Administration/CFSAN/OPA/ DHEE, 200 "C" St. SW, HFS-225, Washington, DC 20204; 3: U.S. Food and Drug Administration/CFSAN/OPA/DPP, 200 "C" St. SW, HFS-207, Washington, DC 20204; 4: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 5: Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536; 6: Department of Microbiology and Immunology and Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky 40536; Issue Info: Apr2001, Vol. 60 Issue 2, p271; Thesaurus Term: Carcinogenesis; Thesaurus Term: Dibutyl phthalate; Subject Term: Peroxisomes; Subject Term: Superoxide dismutase; Subject Term: Vitamin E; Subject Term: Vitamin C; Author-Supplied Keyword: α-tocopherol; Author-Supplied Keyword: α-tocopherol; Author-Supplied Keyword: 643; Author-Supplied Keyword: ascorbic acid; Author-Supplied Keyword: dibutyl phthalate; Author-Supplied Keyword: DT-diaphorase; Author-Supplied Keyword: gemfibrozil; Author-Supplied Keyword: peroxisome proliferator (PP); Author-Supplied Keyword: Sprague-Dawley rat; Author-Supplied Keyword: superoxide dismutase; Author-Supplied Keyword: Syrian hamster; Author-Supplied Keyword: Wy-14; Author-Supplied Keyword: Wy-14,643; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simeonova, Petia P.
AU - Shiyi Wang
AU - Kashon, Michael L.
AU - Kommineni, Choudari
AU - Crecelius, Eric
AU - Luster, Michael I.
T1 - Quantitative Relationship between Arsenic Exposure and AP-1 Activity in Mouse Urinary Bladder Epithelium.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/04//
VL - 60
IS - 2
M3 - Article
SP - 279
EP - 284
PB - Oxford University Press / USA
SN - 10966080
AB - Because of the potential of arsenic for causing cancer in humans, and of the fact of widespread environmental and occupational exposure, deriving acceptable human-limit values has been of major concern to industry as well as to regulatory agencies. Based upon epidemiological evidence and mechanistic studies, it has been argued that a non-linear dose-response model at low-level exposures is more appropriate for calculating risk than the more commonly employed linear-response models. In the present studies, dose-response relationships and recovery studies employing a cancer precursor marker, i.e., activating protein (AP)-1 DNA-binding activity, were examined in bladders of mice exposed to arsenic in drinking water and compared to histopathological changes and arsenic tissue levels in the same tissue. While AP-1 is a functionally pleomorphic transcription factor regulating diverse gene activities, numerous studies have indicated that activation of the MAP kinase pathway and subsequently increased AP-1 binding activities, is a precursor for arsenic-induced cancers of internal organs as well as the skin. We observed previously that within 8 weeks of exposure AP-1 activation occurs in urinary bladder tissue of mice exposed to arsenic in the drinking water. In the present studies, C57BL/6 mice were exposed to sodium arsenite at various concentrations in the drinking water for 8 consecutive weeks. Minimal but observable AP-1 activity occurred in bladder tissue at exposure levels below which histopathological changes or arsenic tissue accumulation was detected. Marked AP-1 DNA-binding activity only occurred at exposure levels of sodium arsenite above 20 μg/ml, where histopathological changes and accumulation of arsenic in the urinary bladder epithelium occurred. Although the experimental design did not allow statistical modeling of the entire dose-response curve, the general shape of the dose-response curve is not inconsistent with the previously proposed hypothesis that arsenic-induced cancer follows a non-linear dose-response model. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases -- Causes & theories of causation
KW - Arsenic -- Physiological effect
KW - Environmentally induced diseases
KW - Occupational diseases
KW - Cancer -- Risk factors
KW - arsenic
KW - cancer
KW - cancer causes
KW - EPA levels
KW - mechanism
KW - mechanism.
KW - risk assessment
N1 - Accession Number: 44406122; Simeonova, Petia P. 1; Shiyi Wang 1; Kashon, Michael L. 2; Kommineni, Choudari 3; Crecelius, Eric 4; Luster, Michael I. 1; Email Address: mluster@cdc.gov; Affiliations: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown West Virginia 26505-2888; 2: Biostatistics Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown West Virginia 26505-2888; 3: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown West Virginia 26505-2888; 4: Battelle Marine Sciences Laboratory, 1529 West Sequim Bay Road, Sequim, Washington 98382-9099; Issue Info: Apr2001, Vol. 60 Issue 2, p279; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Arsenic -- Physiological effect; Thesaurus Term: Environmentally induced diseases; Thesaurus Term: Occupational diseases; Subject Term: Cancer -- Risk factors; Author-Supplied Keyword: arsenic; Author-Supplied Keyword: cancer; Author-Supplied Keyword: cancer causes; Author-Supplied Keyword: EPA levels; Author-Supplied Keyword: mechanism; Author-Supplied Keyword: mechanism.; Author-Supplied Keyword: risk assessment; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mathur, Sheerin
AU - Constable, Peter D.
AU - Eppley, Robert M.
AU - Tumbleson, Mike E.
AU - Smith, Geoffrey W.
AU - Tranquilli, William J.
AU - Morin, Dawn E.
AU - Haschek, Wanda M.
T1 - Fumonisin B1 Increases Serum Sphinganine Concentration but Does Not Alter Serum Sphingosine Concentration or Induce Cardiovascular Changes in Milk-Fed Calves.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/04//
VL - 60
IS - 2
M3 - Article
SP - 379
EP - 384
PB - Oxford University Press / USA
SN - 10966080
AB - Fumonisin B1 is the most toxic and commonly occurring form of a group of mycotoxins that alter sphingolipid biosynthesis and induce leukoencephalomalacia in horses and pulmonary edema in pigs. Purified fumonisin B1 (1 mg/kg, iv, daily) increased serum sphinganine and sphingosine concentrations and decreased cardiovascular function in pigs within 5 days. We therefore examined whether the same dosage schedule of fumonisin B1 produced a similar effect in calves. Ten milk-fed male Holstein calves were instrumented to obtain blood and cardiovascular measurements. Treated calves (n = 5) were administered purified fumonisin B1 at 1 mg/kg, iv, daily for 7 days and controls (n = 5) were administered 10 ml 0.9% NaCl, iv, daily. Each calf was euthanized on day 7. In treated calves, serum sphinganine concentration increased from day 3 onward (day 7, 0.237 ± 0.388 μmol/l; baseline, 0.010 ± 0.007 μmol/l; mean ± SD), whereas, serum sphingosine concentration was unchanged (day 7, 0.044 ± 0.065 μmol/l; baseline, 0.021 ± 0.025 μmol/l). Heart rate, cardiac output, stroke volume, mean arterial pressure, mean pulmonary artery pressure, pulmonary artery wedge pressure, central venous pressure, plasma volume, base-apex electrocardiogram, arterial Po2, and systemic oxygen delivery were unchanged in treated and control calves. Fumonisin-treated calves developed metabolic acidosis (arterial blood pH, 7.27 ± 0.11; base excess, –9.1 ± 7.6 mEq/l), but all survived for 7 days. We conclude that calves are more resistant to fumonisin B1 cardiovascular toxicity than pigs. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fumonisins
KW - Sphingosine
KW - Sphingolipids
KW - Cardiovascular toxicology
KW - Acidosis
KW - cardiovascular toxicity
KW - fumonisin
KW - metabolic acidosis
KW - sphinganine
KW - sphingolipid
KW - sphingosine
N1 - Accession Number: 44406133; Mathur, Sheerin 1; Constable, Peter D. 1; Email Address: p-constable@uiuc.edu; Eppley, Robert M. 2; Tumbleson, Mike E. 3; Smith, Geoffrey W. 1; Tranquilli, William J. 1; Morin, Dawn E. 1; Haschek, Wanda M. 4; Affiliations: 1: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 2: U.S. Food and Drug Administration, Washington, DC; 3: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 4: Department of Veterinary Pathology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; Issue Info: Apr2001, Vol. 60 Issue 2, p379; Subject Term: Fumonisins; Subject Term: Sphingosine; Subject Term: Sphingolipids; Subject Term: Cardiovascular toxicology; Subject Term: Acidosis; Author-Supplied Keyword: cardiovascular toxicity; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: metabolic acidosis; Author-Supplied Keyword: sphinganine; Author-Supplied Keyword: sphingolipid; Author-Supplied Keyword: sphingosine; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mathur, Sheerin
AU - Constable, Peter D.
AU - Eppley, Robert M.
AU - Waggoner, Amy L.
AU - Tumbleson, Mike E.
AU - Haschek, Wanda M.
T1 - Fumonisin B1 Is Hepatotoxic and Nephrotoxic in Milk-Fed Calves.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/04//
VL - 60
IS - 2
M3 - Article
SP - 385
EP - 396
PB - Oxford University Press / USA
SN - 10966080
AB - Fumonisins are a group of mycotoxins that alter sphingolipid biosynthesis and induce leukoencephalomalacia in horses and pulmonary edema in pigs. Experimental administration of fumonisin induces hepatotoxicity in all species, including cattle, as well as nephrotoxicity in rats, rabbits, and sheep. We investigated the hepatotoxicity and nephrotoxicity of fumonisin B1 to calves. Ten milk-fed male Holstein calves aged 7 to 14 days were instrumented to obtain blood and urine. Treated calves (n = 5) were administered fumonisin B1 at 1 mg/kg, iv, daily and controls (n = 5) 10 ml 0.9% NaCl, iv, daily until euthanized on day 7. Fumonisin B1-treated calves were lethargic and had decreased appetite from day 4 onward, serum biochemical evidence of severe liver and bile duct injury, and impaired hepatic function. Treated calves also had biochemical evidence of renal injury that functionally involved the proximal convoluted tubules. Sphinganine and sphingosine concentrations in liver, kidney, lung, heart, and skeletal muscle were increased in treated calves. Sphinganine, but not sphingosine, concentration was increased in brains of treated calves. In fumonisin B1-treated calves, hepatic lesions were characterized by disorganized hepatic cords, varying severity of hepatocyte apoptosis, hepatocyte proliferation, and proliferation of bile ductular cells. Renal lesions in treated calves consisted of vacuolar change, apoptosis, karyomegaly, and proliferation of proximal renal tubular cells, as well as dilation of proximal renal tubules, which contained cellular debris and protein. This is the first report of fumonisin B1-induced renal injury and organ sphingolipid alterations in cattle. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fumonisins
KW - Sphingosine
KW - Sphingolipids
KW - Hepatotoxicology
KW - Cholesterol
KW - Nephrotoxicology
KW - cholesterol
KW - fumonisin
KW - hepatotoxicity
KW - nephrotoxicity
KW - proximal renal tubules
KW - sphinganine
KW - sphingolipid
KW - sphingosine
N1 - Accession Number: 44406134; Mathur, Sheerin 1; Constable, Peter D. 1; Email Address: p-constable@uiuc.edu; Eppley, Robert M. 2; Waggoner, Amy L. 3; Tumbleson, Mike E. 4; Haschek, Wanda M. 5; Affiliations: 1: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 2: U.S. Food and Drug Administration, Washington, DC; 3: Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 4: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802; 5: Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802 v; Issue Info: Apr2001, Vol. 60 Issue 2, p385; Subject Term: Fumonisins; Subject Term: Sphingosine; Subject Term: Sphingolipids; Subject Term: Hepatotoxicology; Subject Term: Cholesterol; Subject Term: Nephrotoxicology; Author-Supplied Keyword: cholesterol; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: nephrotoxicity; Author-Supplied Keyword: proximal renal tubules; Author-Supplied Keyword: sphinganine; Author-Supplied Keyword: sphingolipid; Author-Supplied Keyword: sphingosine; Number of Pages: 12p; Illustrations: 2 Black and White Photographs, 2 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-01642-003
AN - 2002-01642-003
AU - Rhoades, Jeffrey A.
AU - Altman, Barbara M.
T1 - Personal characteristics and contextual factors associated with residential expenditures for individuals with mental retardation.
JF - Mental Retardation
JO - Mental Retardation
JA - Ment Retard
Y1 - 2001/04//
VL - 39
IS - 2
SP - 114
EP - 129
CY - US
PB - American Assn on Mental Retardation
SN - 0047-6765
N1 - Accession Number: 2002-01642-003. PMID: 11340961 Other Journal Title: Intellectual and Developmental Disabilities. Partial author list: First Author & Affiliation: Rhoades, Jeffrey A.; Agency for Healthcare Research & Quality, Rockville, MD, US. Other Publishers: American Association on Intellectual and Developmental Disabilities. Release Date: 20020703. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Long Term Care; Organizational Characteristics; Residential Care Institutions. Minor Descriptor: Client Characteristics; Communities; Data Collection; Facility Environment; Organizations; Intellectual Development Disorder. Classification: Nursing Homes & Residential Care (3377); Mental Retardation (3256). References Available: Y. Page Count: 16. Issue Publication Date: Apr, 2001.
AB - Attempts to demonstrate the need for and usefulness to the current planning process of data collected for individuals residing in facilities for people with mental retardation at the person-level rather than data collected at the organizational level. The authors believe that using data collected at the organizational level to try to solve the kinds of problems facing states today limits the possible solutions to the forms of organizations already in place. Focusing instead on the types of persons for whom services need to be developed allows for more flexibility to ask questions outside the limits that organizational structures impose. A multivariate analysis was done to determine the relative importance of facility, resident, and community characteristics to expenditures. Facility factors associated with higher expenditures included ownership, facility size, facility services, and location. Individuals with a greater number of activity of daily living limitations, developmental disabilities, and more severe levels of mental retardation had higher expenses. Findings could improve the understanding of the costs of long-term residential care, assisting us to economically and effectively bring this population into the community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - data collection
KW - mental retardation
KW - residential care services
KW - organizations
KW - facility
KW - resident
KW - & community characteristics
KW - expenditures
KW - disability limitations
KW - costs of long-term care
KW - 2001
KW - Costs and Cost Analysis
KW - Long Term Care
KW - Organizational Characteristics
KW - Residential Care Institutions
KW - Client Characteristics
KW - Communities
KW - Data Collection
KW - Facility Environment
KW - Organizations
KW - Intellectual Development Disorder
KW - 2001
DO - 10.1352/0047-6765(2001)039<0114:PCACFA>2.0.CO;2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-01642-003&site=ehost-live&scope=site
UR - jrhoades@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106911439
T1 - Perspectives in leadership. Opportunity knocks -- will you listen?
AU - Sparber A
Y1 - 2001/04/02/2001 Apr 2 New Jersey Ed
N1 - Accession Number: 106911439. Language: English. Entry Date: 20020329. Revision Date: 20150711. Publication Type: Journal Article; interview. Supplement Title: 2001 Apr 2 New Jersey Ed. Journal Subset: Nursing; USA. NLM UID: 9892044.
KW - Nursing Leaders -- United States
KW - United States
SP - NJ4
EP - NJ4
JO - Nursing Spectrum -- New York & New Jersey Edition
JF - Nursing Spectrum -- New York & New Jersey Edition
JA - NURS SPECTRUM (NY NJ)
VL - 13A
IS - 7
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1081-3101
AD - Captain, US Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
ID - 106970005
T1 - Statins and fracture risk.
AU - Hennessy S
AU - Strom BL
AU - Hennessy, S
AU - Strom, B L
Y1 - 2001/04/11/
N1 - Accession Number: 106970005. Language: English. Entry Date: 20021018. Revision Date: 20161112. Publication Type: commentary; editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Statins -- Therapeutic Use
KW - Fractures -- Risk Factors
KW - Fractures -- Epidemiology
KW - Bone Density
KW - Fractures -- Prevention and Control
SP - 1888
EP - 1889
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 285
IS - 14
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 11308404.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106970005&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107053486
T1 - Preventing falls from roofs: a critical review.
AU - Hsiao H
AU - Simeonov P
Y1 - 2001/04/15/2001 Apr 15
N1 - Accession Number: 107053486. Language: English. Entry Date: 20010921. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Accidental Falls -- Prevention and Control
KW - Occupational-Related Injuries -- Prevention and Control
KW - Industry
KW - Accidental Falls -- Etiology
KW - Balance, Postural
KW - Biomechanics
KW - Environment
KW - Workload
KW - Vision
KW - Fatigue
KW - Job Experience
KW - Protective Devices
KW - Depth Perception
KW - Sensory Stimulation
KW - Age Factors
KW - Occupational Safety -- Legislation and Jurisprudence
KW - United States Occupational Safety and Health Administration -- Legislation and Jurisprudence
KW - Accidental Falls -- Legislation and Jurisprudence
SP - 537
EP - 561
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 44
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505. E-mail: hhsiao@cdc.gov
U2 - PMID: 11345496.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107076901
T1 - Occupational safety and health training on the Internet: developing quality instruction.
AU - Loos G
AU - Diether JW
Y1 - 2001/05//2001 May
N1 - Accession Number: 107076901. Language: English. Entry Date: 20011214. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669.
KW - Internet
KW - Occupational Safety -- Education
KW - Occupational Health -- Education
KW - Self Directed Learning
KW - United States
KW - Teaching Methods
SP - 231
EP - 234
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 49
IS - 5
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - Training via the Internet (e-training) for adults must be based on the following principles: (1) learning is an active process wherein the learner constructs knowledge rather than acquires it and (2) instruction is a process of supporting this construction rather than communicating knowledge. Etraining can successfully accommodate such features using available technologies.Because e-training is self directed, it is uniquely adaptable to learners with different learning styles, interests, and cultural beliefs. E-training also affords flexible pacing, which is ideal for instruction aimed at both new and experienced workers.As the predicted global economy becomes reality, qualified OSH personnel will be needed on a global scale. To meet new and evolving needs worldwide, professionals must have access to information and training regardless of location. E-training is the most promising approach to meeting this demand.Currently, occupational safety and health e-training does not fulfill its potential. Most training programs do not encourage higher level cognition, critical thinking, or transfer of knowledge. Therefore, training effectiveness research is needed to improve the state of e-training.
SN - 0891-0162
AD - Training and Educational Systems Branch, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH
U2 - PMID: 11760305.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107076901&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107046162
T1 - Review: herbal preparations may improve FEV1 and symptoms in asthma...commentary on Huntley A, Ernst E. Herbal medicines for asthma: a systematic review. THORAX 2000 Nov;55:925-9
AU - Honig PK
Y1 - 2001/05//2001 May-Jun
N1 - Accession Number: 107046162. Language: English. Entry Date: 20010824. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Asthma -- Therapy
KW - Plants, Medicinal -- Therapeutic Use
KW - Medicine, Herbal
KW - Systematic Review
KW - Clinical Trials
KW - Treatment Outcomes
KW - Respiratory Function Tests
KW - Symptoms
KW - Drugs, Chinese Herbal
KW - Medicine, Oriental Traditional
KW - Medicine, Ayurvedic
SP - 96
EP - 96
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 134
IS - 3
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Food and Drug Administration, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wetter, Donald Clark
AU - Daniell, William Edward
AU - Treser, Charles David
T1 - Hospital Preparedness for Victims of Chemical or Biological Terrorism.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/05//
VL - 91
IS - 5
M3 - Article
SP - 710
EP - 716
PB - American Public Health Association
SN - 00900036
AB - Conclusions. Hospital emergency departments generally are not prepared in an organized fashion to treat victims of chemical or biological terrorism. The planned federal efforts to improve domestic preparedness will require substantial additional resources at the local level to be truly effective. (Am J Public Health. 2001;91:710-716) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bioterrorism
KW - Chemical warfare
KW - Hospital emergency services
KW - Preparedness
KW - Medical emergencies
KW - Hospitals
N1 - Accession Number: 5151770; Wetter, Donald Clark 1; Email Address: dwetter@hrsa.gov; Daniell, William Edward 2; Treser, Charles David 2; Affiliations: 1: Office of Emergency Preparedness US Public Health Service Region II, New York, NY; 2: Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle; Issue Info: May2001, Vol. 91 Issue 5, p710; Thesaurus Term: Bioterrorism; Thesaurus Term: Chemical warfare; Subject Term: Hospital emergency services; Subject Term: Preparedness; Subject Term: Medical emergencies; Subject Term: Hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 6285
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106942642
T1 - Hospital preparedness for victims of chemical or biological terrorism.
AU - Wetter DC
AU - Daniell WE
AU - Treser CD
Y1 - 2001/05//
N1 - Accession Number: 106942642. Language: English. Entry Date: 20020726. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Sidel VW, Cohen HW, Gould RM. Good intentions and the road to bioterrorism preparedness. (AM J PUBLIC HEALTH) May2001; 91 (5): 716-718; Henretig F. Biological and chemical terrorism defense: a view from the 'front lines' of public health. (AM J PUBLIC HEALTH) May2001; 91 (5): 718-720; Cone DC. [Commentary on] Hospital preparedness for victims of chemical or biological terrorism. (ANN EMERG MED) 2002 Aug; 40 (2): 267-268. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by the US Public Health Service Office of Emergency Preparedness. NLM UID: 1254074.
KW - Terrorism -- Prevention and Control
KW - Biological Warfare -- Prevention and Control
KW - Health Facility Administration -- Northwestern United States
KW - Emergency Service -- Evaluation -- Northwestern United States
KW - Disaster Planning -- Evaluation
KW - Funding Source
KW - Health Services Research
KW - Surveys
KW - Questionnaires
KW - Northwestern United States
KW - Cross Sectional Studies
KW - Chi Square Test
KW - Fisher's Exact Test
KW - Relative Risk
KW - Confidence Intervals
KW - Data Analysis Software
KW - Antidotes
KW - Protective Clothing
KW - Respiratory Protective Devices
KW - Descriptive Statistics
KW - Patient Isolation
KW - Human
SP - 710
EP - 716
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 91
IS - 5
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study examined hospital preparedness for incidents involving chemical or biological weapons. METHODS: By using a questionnaire survey of 224 hospital emergency departments in 4 northwestern states, we examined administrative plans, training, physical resources, and representative medication inventories. RESULTS: Responses were received from 186 emergency departments (83%). Fewer than 20% of respondent hospitals had plans for biological or chemical weapons incidents. About half (45%) had an indoor or outdoor decontamination unit with isolated ventilation, shower, and water containment systems, but only 12% had 1 or more self-contained breathing apparatuses or supplied air-line respirators. Only 6% had the minimum recommended physical resources for a hypothetical sarin incident. Of the hospitals providing quantitative answers about medication inventories, 64% reported sufficient ciprofloxacin or doxycycline for 50 hypothetical anthrax victims, and only 29% reported sufficient atropine for 50 hypothetical sarin victims (none had enough pralidoxime). CONCLUSIONS: Hospital emergency departments generally are not prepared in an organized fashion to treat victims of chemical or biological terrorism. The planned federal efforts to improve domestic preparedness will require substantial additional resources at the local level to be truly effective.
SN - 0090-0036
AD - Office of Emergency Preparedness, US Public Health Service Region II, 26 Federal Plaza, Room 3835, New York, NY 10278 (dwetter@hrsa.gov)
U2 - PMID: 11344876.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hines, Cynthia J.
AU - Deddens, James A.
T1 - Determinants of chlorpyrifos exposures and urinary 3,5,6-trichloro-2-pyridinol levels among termiticide applicators.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2001/05//
VL - 45
IS - 4
M3 - Article
SP - 309
EP - 321
SN - 00034878
AB - The exposures and work activities of 41 applicators in North Carolina using chlorpyrifos-containing termiticides were characterized. Personal air and urine samples were collected on multiple days within one week. Detailed information about chemical use, tasks, personal protective equipment and hygiene was recorded. During the 202 applicator-days monitored, 415 treatment jobs were performed. Full-shift chlorpyrifos exposures ranged from <0.048 to 110 μg/m3 (N=184), with a geometric mean (GM) of 10 μg/m3. Urinary 3,5,6-trichloro-2-pyridinol (TCP) levels ranged from 9.42 to 1960 μg/g creatinine (N=271) and varied significantly by day of the week (GM range: 169–262 μg/g creatinine). Predictive models for chlorpyrifos air exposure and urinary TCP levels were developed using mixed-effects stepwise linear regression. Determinants of airborne chlorpyrifos exposure included minutes chlorpyrifos applied and enclosed crawl space treated (yes/no). Determinants of TCP levels (depending on the model) included day-of-the-week, the chlorpyrifos air concentration one and two days before urine collection, minutes of chlorpyrifos applied one and two days before urine collection, enclosed crawl space treated (yes/no), and commercial structure treated (time-weighted). Within- and between-worker variablity was similar for airborne chlorpyrifos; however, for TCP, between-worker variability exceeded within-worker variability by six times. The elimination half-life of TCP (26.9 h) and possibly the short sampling interval (one week) may explain the low TCP within-worker variability. Applicators' weekly mean ln(TCP levels) and weekly mean ln(chlorpyrifos air concentrations) were highly and positively linearly correlated (r2=0.73, P<0.0001). In summary, mixed-effects models were successfully constructed to predict airborne chlorpyrifos exposure and urinary TCP levels. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cholinesterase-inhibiting insecticides
KW - Chlorpyrifos
KW - Pesticide applicators (Persons)
KW - Agricultural chemicals -- Physiological effect
KW - Chemicals -- Physiological effect
KW - Protective clothing
KW - Industrial safety
KW - Organophosphorus compounds
KW - Crawl spaces
KW - North Carolina
KW - 3
KW - 3;5;6-trichloro-2-pyridinol
KW - 5
KW - 6-trichloro-2-pyridinol
KW - chlorpyrifos
KW - exposure determinants
KW - mixed models
KW - pesticide
KW - variance components
N1 - Accession Number: 44400131; Hines, Cynthia J. 1; Email Address: chines@cdc.gov; Deddens, James A. 1,2; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; 2: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221, USA; Issue Info: May2001, Vol. 45 Issue 4, p309; Thesaurus Term: Cholinesterase-inhibiting insecticides; Thesaurus Term: Chlorpyrifos; Thesaurus Term: Pesticide applicators (Persons); Thesaurus Term: Agricultural chemicals -- Physiological effect; Thesaurus Term: Chemicals -- Physiological effect; Thesaurus Term: Protective clothing; Thesaurus Term: Industrial safety; Subject Term: Organophosphorus compounds; Subject Term: Crawl spaces; Subject: North Carolina; Author-Supplied Keyword: 3; Author-Supplied Keyword: 3;5;6-trichloro-2-pyridinol; Author-Supplied Keyword: 5; Author-Supplied Keyword: 6-trichloro-2-pyridinol; Author-Supplied Keyword: chlorpyrifos; Author-Supplied Keyword: exposure determinants; Author-Supplied Keyword: mixed models; Author-Supplied Keyword: pesticide; Author-Supplied Keyword: variance components; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 13p; Illustrations: 7 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McCawley, Michael A.
AU - Kent, Michael S.
AU - Berakis, Michael T.
T1 - Ultrafine Beryllium Number Concentration as a Possible Metric for Chronic Beryllium Disease Risk.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/05//
VL - 16
IS - 5
M3 - Article
SP - 631
EP - 638
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Beryllium is a lightweight metal which causes a chronic granulomatous lung disease among workers who become sensitized to it. Recent research has shown a persistence of the disease despite efforts at control with mean exposures below the Occupational Safety and Health Administration (OSHA) occupational exposure limit of 2 μg/m[sup 3]. Results of our current research confirm a previous finding in certain plants that particle number concentrations are higher in areas where historical estimate of risk showed a high risk of disease despite relatively lower mass concentrations. By providing side-by-side measurements of both particle number and mass, this research adds support to the proposal that particle number rather than particle mass may be more reflective of target organ dose and subsequently a more appropriate measure of exposure for chronic beryllium disease. Our evidence also shows that particle mass exposure measurements and particle number exposure measurements were not correlated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Chronic granulomatous disease
KW - Lung diseases
KW - United States
KW - BERYLLIUM SENSITIZATION
KW - Chronic beryllium disease
KW - Lung deposition
KW - Occupational exposure
KW - PARTICLE SIZE
KW - ULTRAFINE AEROSOL
N1 - Accession Number: 5171730; McCawley, Michael A. 1; Kent, Michael S. 2; Berakis, Michael T. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Brush Wellman, Inc., Elmore, Ohio; Issue Info: May2001, Vol. 16 Issue 5, p631; Thesaurus Term: Beryllium; Subject Term: Chronic granulomatous disease; Subject Term: Lung diseases; Subject: United States; Author-Supplied Keyword: BERYLLIUM SENSITIZATION; Author-Supplied Keyword: Chronic beryllium disease; Author-Supplied Keyword: Lung deposition; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: PARTICLE SIZE; Author-Supplied Keyword: ULTRAFINE AEROSOL; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 8p; Illustrations: 1 Chart, 13 Graphs; Document Type: Article
L3 - 10.1080/104732201750169778
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106936638
T1 - The cells of asthma.
AU - Rieves D
Y1 - 2001/05//
N1 - Accession Number: 106936638. Language: English. Entry Date: 20020705. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: St. George's Respiratory Questionnaire (SGRQ). NLM UID: 0231335.
KW - Asthma -- Physiopathology
KW - Eosinophilia
KW - Questionnaires
SP - 1299
EP - 1300
JO - CHEST
JF - CHEST
JA - CHEST
VL - 119
IS - 5
CY - Glenview, Illinois
PB - American College of Chest Physicians
SN - 0012-3692
AD - Medical Officer, Center for Biologics Evaluation and Research, US Food and Drug Administration
U2 - PMID: 11348929.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106811547
T1 - Sensation seeking needs among 8th and 11th graders: characteristics associated with cigarette and marijuana use.
AU - Kopstein AN
AU - Crum RM
AU - Celentano DD
AU - Martin SS
Y1 - 2001/05//
N1 - Accession Number: 106811547. Language: English. Entry Date: 20030228. Revision Date: 20150711. Publication Type: Journal Article; questionnaire/scale; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: University of Delaware Contract Funds, two Federal CSAP Coalition grants and a Scientist Development Award for Clinicians from the National Institute on Alcohol Abuse and Alcoholism. NLM UID: 7513587.
KW - Risk Taking Behavior -- In Adolescence
KW - Smoking -- In Adolescence
KW - Cannabis -- Administration and Dosage -- In Adolescence
KW - Descriptive Statistics
KW - Scales
KW - Univariate Statistics
KW - Multiple Regression
KW - Goodness of Fit Chi Square Test
KW - P-Value
KW - Pearson's Correlation Coefficient
KW - Data Analysis, Statistical
KW - Data Analysis Software
KW - Odds Ratio
KW - Confidence Intervals
KW - Sex Factors
KW - Adolescence
KW - Male
KW - Female
KW - Funding Source
KW - Human
SP - 195
EP - 203
JO - Drug & Alcohol Dependence
JF - Drug & Alcohol Dependence
JA - DRUG ALCOHOL DEPENDENCE
VL - 62
IS - 3
PB - Elsevier Science
AB - This cross-sectional school-based study explored the relationship between adolescent use of cigarettes and marijuana and the sensation seeking personality factors of (1) Disinhibition and (2) Thrill and Adventure Seeking. The study population included a representative sample of both male and female 8th and 11th graders in the state of Delaware. Analytic methods utilized included correlational analysis and multivariate logistic regression. In the multivariate logistic regression models, the Disinhibition personality factor accounted for cigarette and marijuana using behaviors with odds ratios ranging between 2 and 3. Thrill and Adventure Seeking was not a significant explanatory variable in any of the final multivariate models. Potential confounders (age, gender and race) were considered in all analyses. Of all the two-way interactions assessed, none was significant. The findings from this study utilizing a large general community sample indicate that sensation seeking needs are a potential risk factor for adolescent substance use.
SN - 0376-8716
AD - Division of Population Surveys, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Room 16-105, 5600 Fishers, Lane, Rockville, MD 20857
U2 - PMID: 11295324.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bacon, David J.
AU - Szymanski, Christine M.
AU - Burr, Don H.
AU - Silver, Richard P.
AU - Alm, Richard A.
AU - Guerry, Patricia
T1 - A phase-variable capsule is involved in virulence of Campylobacter jejuni 81-176.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2001/05//
VL - 40
IS - 3
M3 - Article
SP - 769
EP - 777
PB - Wiley-Blackwell
SN - 0950382X
AB - Campylobacter jejuni strain 81-176 (HS36, 23) synthesizes two distinct glycan structures, as visualized by immunoblotting of proteinase K-digested whole-cell preparations. A site-specific insertional mutant in the kpsM gene results in loss of expression of a high-molecular-weight (HMW) glycan (apparent Mr 26 kDa to > 85 kDa) and increased resolution of a second ladder-like glycan (apparent Mr 26–50 kDa). The kpsM mutant of 81-176 is no longer typeable in either HS23 or HS36 antisera, indicating that the HMW glycan structure is the serodeterminant of HS23 and HS36. Both the kpsM-dependent HMW glycan and the kpsM-independent ladder-like structure appear to be capsular in nature, as both are attached to phospholipid rather than lipid A. Additionally, the 81-176 kpsM gene can complement a deletion in Escherichia coli kpsM, allowing the expression of an α2,8 polysialic acid capsule in E. coli. Loss of the HMW glycan in 81-176 kpsM also increases the surface hydrophobicity and serum sensitivity of the bacterium. The kpsM mutant is also significantly reduced in invasion of INT407 cells and reduced in virulence in a ferret diarrhoeal disease model. The expression of the kpsM-dependent capsule undergoes phase variation at a high frequency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter jejuni
KW - Virulence (Microbiology)
KW - Genetics
N1 - Accession Number: 4537954; Bacon, David J. 1; Szymanski, Christine M. 1; Burr, Don H. 2; Silver, Richard P. 3; Alm, Richard A. 4; Guerry, Patricia 1; Affiliations: 1: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.; 2: Food and Drug Administration, Laurel, MD, USA.; 3: Department of Microbiology, University of Rochester, Rochester, NY, USA.; 4: Astra Zeneca Boston, Waltham, MA, USA.; Issue Info: May2001, Vol. 40 Issue 3, p769; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Genetics; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2958.2001.02431.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107026440
T1 - Device safety. Eyeing the perils of LASIK surgery.
AU - Woo E
Y1 - 2001/05//
N1 - Accession Number: 107026440. Language: English. Entry Date: 20050817. Revision Date: 20150711. Publication Type: Journal Article; brief item; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Laser Therapy -- Adverse Effects
KW - Surgery, Eye -- Adverse Effects
KW - Postoperative Complications
KW - Consumer Health Information
KW - United States Food and Drug Administration
SP - 28
EP - 28
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107057028
T1 - An assessment of thimerosal use in childhood vaccines.
AU - Ball LK
AU - Ball R
AU - Pratt RD
Y1 - 2001/05//
N1 - Accession Number: 107057028. Language: English. Entry Date: 20011005. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Vaccines -- In Infancy and Childhood
KW - Mercury
KW - Risk Assessment
KW - Child
KW - Hypersensitivity
SP - 1147
EP - 1154
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 107
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - Background. On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from the Food and Drug Administration that is presented here. Methods. The risk assessment consisted of hazard identification, dose-response assessment, exposure assessment, and risk characterization. The literature was reviewed to identify known toxicity of thimerosal, ethylmercury (a metabolite of thimerosal) and methylmercury (a similar organic mercury compound) and to determine the doses at which toxicity occurs. Maximal potential exposure to mercury from vaccines was calculated for children at 6 months old and 2 years, under the US childhood immunization schedule, and compared with the limits for mercury exposure developed by the Environmental Protection Agency (EPA), the Agency for Toxic Substance and Disease Registry, the Food and Drug Administration, and the World Health Organization. Results. Delayed-type hypersensitivity reactions from thimerosal exposure are well-recognized. Identified acute toxicity from inadvertent high-dose exposure to thimerosal includes neurotoxicity and nephrotoxicity. Limited data on toxicity from low-dose exposures to ethylmercury are available, but toxicity may be similar to that of methylmercury. Chronic, low-dose methylmercury exposure may cause subtle neurologic abnormalities. Depending on the immunization schedule, vaccine formulation, and infant weight, cumulative exposure of infants to mercury from thimerosal during the first 6 months of life may exceed EPA guidelines. Conclusion. Our review revealed no evidence of harm caused by doses of thimerosal in vaccines, except for local hypersensitivity reactions. However, some infants may be exposed to cumulative levels of mercury during the first 6 months of life that exceed EPA recommendations. Exposure of infants to mercury in vaccines can be reduced or eliminated by using products formulated without thimerosal as a preservative.
SN - 0031-4005
AD - Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Food and Drug Administration, Rockville, Maryland
U2 - PMID: 11331700.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Feinian Chen
AU - Bollen, Kenneth A.
AU - Paxton, Pamela
AU - Curran, Patrick J.
AU - Kirby, James B.
T1 - Improper Solutions in Structural Equation Models.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 2001/05//
VL - 29
IS - 4
M3 - Article
SP - 468
SN - 00491241
AB - In this article, the authors examine the most common type of improper solutions: zero or negative error variances. They address the causes of, consequences of, and strategies to handle these issues. Several hypotheses are evaluated using Monte Carlo simulation models, including two structural equation models with several misspecifications of each model. Results suggested several unique findings. First, increasing numbers of omitted paths in the measurement model were associated with decreasing numbers of improper solutions. Second, bias in the parameter estimates was higher in samples with improper solutions than in samples including only proper solutions. Third, investigation of the consequences of using constrained estimates in the presence of improper solutions indicated that inequality constraints helped some samples achieve convergence. Finally, the use of confidence intervals as well as four other proposed tests yielded similar results when testing whether the error variance was greater than or equal to zero. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methods & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIOLOGY -- Statistical methods
KW - STATISTICAL hypothesis testing
KW - ESTIMATION theory
KW - SAMPLING (Statistics)
KW - SIMULATION methods & models
KW - MONTE Carlo method
KW - SOCIAL sciences -- Methodology
N1 - Accession Number: 4352631; Feinian Chen 1; Bollen, Kenneth A. 1; Paxton, Pamela 2; Curran, Patrick J. 1; Kirby, James B. 3; Source Information: May2001, Vol. 29 Issue 4, p468; Subject: SOCIOLOGY -- Statistical methods; Subject: STATISTICAL hypothesis testing; Subject: ESTIMATION theory; Subject: SAMPLING (Statistics); Subject: SIMULATION methods & models; Subject: MONTE Carlo method; Subject: SOCIAL sciences -- Methodology; Number of Pages: 41p; Illustrations: 2 Diagrams, 7 Graphs; Document Type: Article; Full Text Word Count: 13236
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Dragan, Yvonne P.
AU - Bidlack, Wayne R.
AU - Cohen, Samuel M.
AU - Goldsworthy, Thomas L.
AU - Hard, Gordon C.
AU - Howard, Paul C.
AU - Riley, Ronald T.
AU - Voss, Kenneth A.
T1 - Implications of Apoptosis for Toxicity, Carcinogenicity, and Risk Assessment: Fumonisin B1 as an Example.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/05//
VL - 61
IS - 1
M3 - Article
SP - 6
EP - 17
PB - Oxford University Press / USA
SN - 10966080
AB - The rates of cell proliferation and cell loss in conjunction with the differentiation status of a tissue are among the many factors contributing to carcinogenesis. Nongenotoxic (non-DNA reactive) chemicals may affect this balance by increasing proliferation through direct mitogenesis or through a regenerative response following loss of cells through cytotoxic (oncotic) or apoptotic necrosis. In a recent NTP study in Fischer rats and B6C3F1 mice, the mycotoxin fumonisin B1 caused renal carcinomas in male rats and liver cancer in female mice. In an earlier study in male BD-IX rats, fumonisin B1 caused hepatic toxicity and hepatocellular carcinomas. An early effect of fumonisin B1 exposure in these target organs is apoptosis. However, there is also some evidence of oncotic necrosis following fumonisin B1 administration, especially in the liver. Induction of apoptosis may be a consequence of ceramide synthase inhibition and disruption of sphingolipid metabolism by fumonisin B1. Fumonisin B1 is not genotoxic in bacterial mutagenesis screens or in the rat liver unscheduled DNA-synthesis assay. Fumonisin B1 may be the first example of an apparently nongenotoxic (non-DNA reactive) agent producing tumors through a mode of action involving apoptotic necrosis, atrophy, and consequent regeneration. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Cell proliferation
KW - Tissues
KW - Liver -- Cancer
KW - Fumonisins
KW - Ceramides
KW - Metabolism
KW - apoptosis
KW - carcinogenesis
KW - fumonisin
KW - kidney cancer
KW - liver cancer
KW - mycotoxins
KW - regeneration
N1 - Accession Number: 44406153; Dragan, Yvonne P. 1; Bidlack, Wayne R. 2; Cohen, Samuel M. 3; Email Address: scohen@unmc.edu; Goldsworthy, Thomas L. 4; Hard, Gordon C. 5; Howard, Paul C. 6; Riley, Ronald T. 7; Voss, Kenneth A. 7; Affiliations: 1: Ohio State University, James Cancer Center, 1148 James CHRI, 300 W. 10th Avenue, Columbus, Ohio 43210-1240; 2: California State Polytechnic University-Pomona, College of Agriculture, 3801 W. Temple Avenue, Pomona, California 91768; 3: University of Nebraska Medical Center, Department of Pathology and Microbiology, 983135 Nebraska Medical Center, Omaha, Nebraska 68198-3135; 4: Integrated Laboratory Systems, Inc., Health Science Division, P.O. Box 13501, Research Triangle Park, North Carolina 27709; 5: American Health Foundation, One Dana Road, Valhalla, New York 10595; 6: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Drive, Jefferson, Arkansas 72079-9502; 7: USDA, Toxicology and Mycotoxin Research Unit, P.O. Box 5677, Athens, Georgia 30604-5677; Issue Info: May2001, Vol. 61 Issue 1, p6; Thesaurus Term: Carcinogenesis; Subject Term: Cell proliferation; Subject Term: Tissues; Subject Term: Liver -- Cancer; Subject Term: Fumonisins; Subject Term: Ceramides; Subject Term: Metabolism; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: kidney cancer; Author-Supplied Keyword: liver cancer; Author-Supplied Keyword: mycotoxins; Author-Supplied Keyword: regeneration; Number of Pages: 12p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hubbs, A. F.
AU - Minhas, N. S.
AU - Jones, W.
AU - Greskevitch, M.
AU - Battelli, L. A.
AU - Porter, D. W.
AU - Goldsmith, W. T.
AU - Frazer, D.
AU - Landsittel, D. P.
AU - Ma, J. Y. C.
AU - Barger, M.
AU - Hill, K.
AU - Schwegler-Berry, D.
AU - Robinson, V. A.
AU - Castranova, V.
T1 - Comparative Pulmonary Toxicity of 6 Abrasive Blasting Agents.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/05//
VL - 61
IS - 1
M3 - Article
SP - 135
EP - 143
PB - Oxford University Press / USA
SN - 10966080
AB - Inhalation of silica dust is associated with pulmonary fibrosis. Therefore, substitute abrasive materials have been suggested for use in abrasive blasting operations. To date, toxicological evaluation of most substitute abrasives has been incomplete. Therefore, the objective of this study was to compare the pulmonary toxicity of a set of substitute abrasives (garnet, staurolite, coal slag, specular hematite, and treated sand) to that of blasting sand. Rats were exposed to blasting sand or an abrasive substitute by intratracheal instillation and pulmonary responses to exposure were monitored 4 weeks postexposure. Pulmonary damage was monitored as lactate dehydrogenase (LDH) in the acellular lavage fluid. Pulmonary inflammation was evaluated from the yield of polymorphonuclear leukocytes (PMN) obtained by bronchoalveolar lavage. The activity of alveolar macrophages was determined by measuring zymosan-stimulated chemiluminescence. Blasting sand caused lung damage and showed histologic evidence for inflammation and fibrosis. Garnet, staurolite, and treated sand exhibited toxicity and inflammation that were similar to blasting sand, while coal slag caused greater pulmonary damage and inflammation than blasting sand. In contrast, specular hematite did not significantly elevate LDH or PMN levels and did not stimulate macrophage activity 4 weeks postexposure. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silica dust
KW - Occupational hazards
KW - Toxicology
KW - Pulmonary fibrosis
KW - Lactate dehydrogenase
KW - Chemiluminescence
KW - Inflammation
KW - coal slag
KW - fibrosis
KW - fibrosis.
KW - garnet
KW - inflammation
KW - iron oxide
KW - lung
KW - quartz
KW - sand
KW - silica
KW - specular hematite
KW - staurolite
N1 - Accession Number: 44406147; Hubbs, A. F. 1; Email Address: afh0@cdc.gov; Minhas, N. S. 1; Jones, W. 2; Greskevitch, M. 2; Battelli, L. A. 1; Porter, D. W. 1; Goldsmith, W. T. 1; Frazer, D. 1; Landsittel, D. P. 1; Ma, J. Y. C. 1; Barger, M. 1; Hill, K. 1; Schwegler-Berry, D. 1; Robinson, V. A. 1; Castranova, V. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505; 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505; Issue Info: May2001, Vol. 61 Issue 1, p135; Thesaurus Term: Silica dust; Thesaurus Term: Occupational hazards; Thesaurus Term: Toxicology; Subject Term: Pulmonary fibrosis; Subject Term: Lactate dehydrogenase; Subject Term: Chemiluminescence; Subject Term: Inflammation; Author-Supplied Keyword: coal slag; Author-Supplied Keyword: fibrosis; Author-Supplied Keyword: fibrosis.; Author-Supplied Keyword: garnet; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: iron oxide; Author-Supplied Keyword: lung; Author-Supplied Keyword: quartz; Author-Supplied Keyword: sand; Author-Supplied Keyword: silica; Author-Supplied Keyword: specular hematite; Author-Supplied Keyword: staurolite; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 1 Chart, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boucher, Philip E.
AU - Yang, Mei-Shin
AU - Stibitz, Scott
T1 - Mutational analysis of the high-affinity BvgA binding site in the fha promoter of Bordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2001/05/15/
VL - 40
IS - 4
M3 - Article
SP - 991
EP - 999
PB - Wiley-Blackwell
SN - 0950382X
AB - In order to define a consensus binding sequence for the response regulator BvgA, we have undertaken a systematic analysis of contributions made by each nucleotide within the heptad half-sites that are present in an inverted orientation at the promoter for the fha operon. Using in vitro binding assays, we examined the full complement of 21 single point mutations symmetrically arranged in this heptad repeat. Both gel shift and nitrocellulose filter-binding assays provided evidence that nucleotides at positions 3 (thymidine), 4 (cytosine) and 7 (adenine) in the binding heptad contribute substantially to sequence-specific recognition by BvgA. Furthermore, a T to A conversion at position 6 reduced binding. Selected binding site mutations were introduced into a modified fha promoter and examined for their effects on BvgA activation of promoter activity in vivo. Only those substitutions most severely affecting binding in vitro affected promoter activity in vivo. The in vivo effects of substitutions that had a significant effect on binding in vitro but did not severely affect in vivo promoter activity under standard culture conditions could be detected in vivo either in combination with additional substitutions or from their effect on the sensitivity of the mutant promoters to modulation by magnesium sulphate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Binding sites (Biochemistry)
KW - Proteins
KW - Nucleotide sequence
KW - Genetic regulation
KW - Bordetella pertussis
N1 - Accession Number: 5170078; Boucher, Philip E.; Yang, Mei-Shin 1; Stibitz, Scott 1; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.; Issue Info: May2001, Vol. 40 Issue 4, p991; Thesaurus Term: Binding sites (Biochemistry); Subject Term: Proteins; Subject Term: Nucleotide sequence; Subject Term: Genetic regulation; Subject Term: Bordetella pertussis; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2958.2001.02442.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Craft, Edwin M.
AU - Mulvey, Kevin P.
T1 - Addressing Lesbian, Gay, Bisexual, and Transgender Issues From the Inside: One Federal Agency's Approach.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/06//
VL - 91
IS - 6
M3 - Article
SP - 889
EP - 891
PB - American Public Health Association
SN - 00900036
AB - SAMHSA works in partnership with states, communities, and private organizations to address the needs of people with substance abuse and mental illnesses as well as the community risk factors that contribute to these illnesses. As part of its efforts to address the unique needs of special populations, SAMHSA has reached out to the lesbian, gay, bisexual, and transgender (LGBT) community. SAMHSA and its centers (Center for Substance Abuse Treatment, Center for Substance Abuse Prevention, and Center for Mental Health Services) have made a concerted effort, through both policy and programs, to develop services responsive to this community. (Am J Public Health. 2001;91:889-891) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical care -- United States
KW - LGBT community health services
KW - Government agencies
KW - Medically underserved areas
KW - Substance abuse
KW - United States
KW - United States. Substance Abuse & Mental Health Services Administration
N1 - Accession Number: 4528242; Craft, Edwin M. 1; Email Address: ecraft@samhsa.gov; Mulvey, Kevin P. 1; Affiliations: 1: Substance Abuse and Mental Health Services Administration, and the US Department of Health and Human Services, Rockville, Md.; Issue Info: Jun2001, Vol. 91 Issue 6, p889; Subject Term: Medical care -- United States; Subject Term: LGBT community health services; Subject Term: Government agencies; Subject Term: Medically underserved areas; Subject Term: Substance abuse; Subject: United States ; Company/Entity: United States. Substance Abuse & Mental Health Services Administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2054
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106950178
T1 - Addressing lesbian, gay, bisexual, and transgender issues from the inside: one federal agency's approach.
AU - Craft EM
AU - Mulvey KP
Y1 - 2001/06//
N1 - Accession Number: 106950178. Language: English. Entry Date: 20020816. Revision Date: 20150711. Publication Type: Journal Article; practice guidelines; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Government Agencies
KW - Organizational Objectives
KW - Homosexuality -- Legislation and Jurisprudence -- United States
KW - Health Services Accessibility -- Standards
KW - Health Policy
KW - United States
KW - Lesbians
KW - Gay Men
KW - Bisexuals
KW - Transsexualism
KW - Substance Use Disorders -- Therapy
KW - Research Priorities
KW - Mental Disorders -- Therapy
KW - Male
KW - Female
SP - 889
EP - 891
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 91
IS - 6
CY - Washington, District of Columbia
PB - American Public Health Association
AB - The mission of the Substance Abuse and Mental Health Services Administration (SAMHSA) is to protect and serve underserved and vulnerable populations. Congress established SAMHSA under Public Law 102-321 on October 1, 1992, to strengthen the nation's health care capacity to provide prevention, diagnosis, and treatment services for substance abuse and mental illnesses. SAMHSA works in partnership with states, communities, and private organizations to address the needs of people with substance abuse and mental illnesses as well as the community risk factors that contribute to these illnesses. As part of its efforts to address the unique needs of special populations, SAMHSA has reached out to the lesbian, gay, bisexual, and transgender (LGBT) community. SAMHSA and its centers (Center for Substance Abuse Treatment, Center for Substance Abuse Prevention, and Center for Mental Health Services) have made a concerted effort, through both policy and programs, to develop services responsive to this community.
SN - 0090-0036
AD - Center for Substance Abuse Treatment, Rockwall II, Suite 840, 5600 Fisher Ln, Rockville, MD 20857 (ecraft@samhsa.gov)
U2 - PMID: 11392928.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Boeniger, Mark F.
AU - Lummus, Zana L.
AU - Biagini, Raymond E.
AU - Bernstein, David I.
AU - Swanson, Mark C.
AU - Reed, Charles
AU - Massoudi, Mehran
T1 - Exposure to Protein Aeroallergens in Egg Processing Facilities.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/06//
VL - 16
IS - 6
M3 - Article
SP - 660
EP - 670
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Proteinaceous materials in the air can be highly allergenic and result in a range of immunologically mediated respiratory effects, including asthma. We report on the largest evaluation of exposure to date of airborne egg protein concentrations in an egg breaking and processing plant that had cases of occupational asthma. Personal air samples for egg protein were analyzed in duplicate on each PTFE filter using two analytical methods: (1) a commercial assay for non-specific total protein, and (2) indirect competitive inhibition assay using an ELISA method to quantify specific egg protein components. The highest concentrations were found in the egg washing room (mean exposure 644 μg/m[sup 3]) and breaking room (255 μg/m[sup 3]), which were also the areas where the risk of being sensitized was the greatest. There was excellent quantitative agreement between the airborne concentrations of total protein and sum of the specific protein antigens (ovalbumin, ovomucoid, and lysozyme). The correlation coefficient of the log-transformed data from the two methods was 0.88 (p < 0.0001). Size-selective sampling also indicated that most of the aerosol was capable of reaching the small airways. The methods described can be utilized to evaluate employee exposure to egg proteins. Exposure documentation, coupled with recommended exposure reduction strategies, could facilitate prevention of future employee sensitization and allergic respiratory responses by identifying high-exposure jobs and evaluating control measures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - DISEASES
KW - Asthma
KW - Egg products industry
KW - Employees
KW - Allergy
KW - Occupational asthma
KW - Occupational exposure
KW - Protein
KW - Sensitization
N1 - Accession Number: 4485612; Boeniger, Mark F. 1; Lummus, Zana L. 2; Biagini, Raymond E. 1; Bernstein, David I. 2; Swanson, Mark C. 3; Reed, Charles 3; Massoudi, Mehran 4; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: University of Cincinnati Allergy Lab, Cincinnati, Ohio; 3: Mayo Clinic, Rochester,Minnesota; 4: Centers for Disease Control and Prevention, Atlanta, Georgia; Issue Info: Jun2001, Vol. 16 Issue 6, p660; Thesaurus Term: Allergens; Thesaurus Term: DISEASES; Thesaurus Term: Asthma; Subject Term: Egg products industry; Subject Term: Employees; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Occupational asthma; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: Protein; Author-Supplied Keyword: Sensitization; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/104732201750175861
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tucker, Samuel P.
AU - Reynolds, John M.
AU - Wickman, Don C.
AU - Hines, Cynthia J.
AU - Perkins, James B.
T1 - Development of Sampling and Analytical Methods for Concerted Determination of Commonly Used Chloroacetanilide, Chlorotriazine, and 2,4-D Herbicides in Hand-Wash, Dermal-Patch, and Air Samples.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/06//
VL - 16
IS - 6
M3 - Article
SP - 698
EP - 707
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Sampling and analytical methods were developed for commonly used chloroacetanilide, chlorotriazine, and 2,4- D herbicides in hand washes, on dermal patches, and in air. Eight herbicides selected for study were alachlor, atrazine, cyanazine, 2,4-dichlorophenoxyacetic acid (2,4-D), metolachlor, simazine, and two esters of 2,4-D, the 2-butoxyethyl ester (2,4-D, BE) and the 2-ethylhexyl ester (2,4-D, EH). The hand-wash method consisted of shaking the worker'shand in 150 mL of isopropanol in a polyethylene bag for 30 seconds. The dermal-patch method entailed attaching a 10-cm × 10-cm × 0.6-cm polyurethane foam (PUF) patch to the worker for exposure; recovery of the herbicides was achieved by extraction with 40 mL of isopropanol. The air method involved sampling with an OVS-2 tube (which contained an 11-mm quartz fiber filter and two beds of XAD-2 resin) and recovery with 2 mL of 10:90 methanol:methyl t-butyl ether. Analysis of each of the three sample types was performed by gas chromatography with an electron-capture detector. Diazomethane in solution was employed to convert 2,4-D as the free acid to the methyl ester in each of the three methods for ease of gas chromatography. Silicic acid was added to sample solutions to quench excess diazomethane. Limits of detection for all eight herbicides were matrix-dependent and, generally, less than 1 microgram per sample for each matrix. Sampling and analytical methods met NIOSH evaluation criteria for all herbicides in hand-wash samples, for seven herbicides in air samples (all herbicides except cyanazine), and for six herbicides in dermal-patch samples (all herbicides except cyanazine and 2,4-D). Speciation of 2,4-D esters and simultaneous determination of 2,4-D acid were possible without losses of the esters or of other herbicides (acetanilides and triazines) being determined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Herbicides
KW - Dichlorophenoxyacetic acid
KW - Health
KW - Acetanilide
KW - Triazines
KW - Employees
KW - 24D ACID
KW - 24D ESTERS
KW - AIR SAMPLES
KW - Chloroacetanilides
KW - Chlorotriazines
KW - DERMAL PATCHES
KW - GAS CHROMATOGRAPHY
KW - HAND WASHES
N1 - Accession Number: 4485619; Tucker, Samuel P. 1; Reynolds, John M. 2; Wickman, Don C. 2; Hines, Cynthia J. 1; Perkins, James B. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: DataChem Laboratories, Inc., Salt Lake City, Utah; Issue Info: Jun2001, Vol. 16 Issue 6, p698; Thesaurus Term: Herbicides; Thesaurus Term: Dichlorophenoxyacetic acid; Thesaurus Term: Health; Subject Term: Acetanilide; Subject Term: Triazines; Subject Term: Employees; Author-Supplied Keyword: 24D ACID; Author-Supplied Keyword: 24D ESTERS; Author-Supplied Keyword: AIR SAMPLES; Author-Supplied Keyword: Chloroacetanilides; Author-Supplied Keyword: Chlorotriazines; Author-Supplied Keyword: DERMAL PATCHES; Author-Supplied Keyword: GAS CHROMATOGRAPHY; Author-Supplied Keyword: HAND WASHES; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/104732201750175942
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107054844
T1 - Changing physician behavior.
AU - Bauchner H
AU - Simpson L
AU - Chessare J
Y1 - 2001/06//
N1 - Accession Number: 107054844. Language: English. Entry Date: 20010928. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0372434.
KW - Physicians
KW - Decision Making, Clinical
KW - Quality of Health Care
KW - Role Change
KW - United Kingdom
KW - Models, Theoretical
SP - 459
EP - 462
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
JA - ARCH DIS CHILD
VL - 84
IS - 6
PB - BMJ Publishing Group
SN - 0003-9888
AD - Adolescent Health Scholar-in-Residence, Agency for Healthcare Research and Quality, 6010 Executive Blvd, Suite 201, Rockville, MD 20852. E-mail: hbauchne@ahrq.gov
U2 - PMID: 11369556.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clements, C.
AU - Ball, L.K.
AU - Ball, R.
AU - Pratt, R.
T1 - Thiomersal in Vaccines: Is Removal Warranted?
JO - Drug Safety
JF - Drug Safety
Y1 - 2001/06//
VL - 24
IS - 8
M3 - Article
SP - 567
EP - 574
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - The mercury-based vaccine preservative thiomersal has come under scrutiny in recent months because of its presence in certain vaccines that provide the foundation of childhood immunisation schedules. Over the past decade new vaccines have been added to the recommended childhood schedule, and the relatively smaller bodyweight of infants has led to concern that the cumulative exposure of mercury from infant vaccines may exceed certain guidelines for the human consumption of mercury. In the US, government agencies and professional societies have recently recommended that thiomersal be removed altogether from vaccines. Some involved in developing vaccine policy feel that the evidence to support these safety concerns has not risen to the level required for such a response. This apparent divergence of opinion has left healthcare professionals and the public with uncertainty about the potential health effects from low level exposure to thiomersal as well as the necessity of removing thiomersal from vaccines. At present, scientific investigation has not found conclusive evidence of harm from thiomersal in vaccines. As a precautionary measure, efforts are under way to remove or replace thiomersal from vaccines and providers should anticipate the availability of more vaccine products that are thiomersal-free over the coming years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccines
KW - Mercury -- Therapeutic use
KW - Preservation of materials
KW - Children
KW - Thiomersal, adverse reactions
KW - Vaccines, adverse reactions
N1 - Accession Number: 4731272; Clements, C. 1; Ball, L.K. 2; Ball, R. 2; Pratt, R. 2; Affiliations: 1: Department of Vaccines and Biologicals, World Health Organization, Geneva, Switzerland; 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Jun2001, Vol. 24 Issue 8, p567; Subject Term: Vaccines; Subject Term: Mercury -- Therapeutic use; Subject Term: Preservation of materials; Author-Supplied Keyword: Children; Author-Supplied Keyword: Thiomersal, adverse reactions; Author-Supplied Keyword: Vaccines, adverse reactions; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Meyer, Joette M.
AU - Silliman, Nancy P.
AU - Dixon, Cheryl A.
AU - Siepman, Nancy Y.
AU - Sugg, Jennifer E.
AU - Hopkins, Robert J.
T1 - Helicobacter pylori and Early Duodenal Ulcer Status Post-Treatment: a Review.
JO - Helicobacter
JF - Helicobacter
Y1 - 2001/06//
VL - 6
IS - 2
M3 - Article
SP - 84
EP - 92
PB - Wiley-Blackwell
SN - 10834389
AB - Abstract Background. Data submitted to the FDA were reviewed to analyze the relationship between Helicobacter pylori infection and the incidence of early duodenal ulcers, within 6 weeks, following treatment. Materials and Methods. Retrospective analyzes were performed on data from three H. pylori development programs submitted to the FDA: ranitidine-bismuth-citrate (RBC), lansoprazole (L) and omeprazole (O). Efficacy assessments for the RBC, L and O programs were made at end of a 4-week treatment period, 4–6 weeks following the end of a 14-day treatment period, and 4 weeks following the end of a 4-week treatment period, respectively. Results. Overall, there was a 15%, 21% and 23% decrease in the number of patients in the RBC, L and O programs, respectively, with ulcers among H. pylori cleared/eradicated patients post-treatment compared with patients with persistent infection. Among patients who did not have cleared/eradicated H. pylori in the RBC and O programs, where antisecretory agents were continued beyond the antimicrobial treatment period, the number of ulcers was lower in the antisecretory plus antimicrobial subgroups compared with the antimicrobial alone subgroups (37% vs. 46% for RBC and 33% vs. 42% for O). Among patients with cleared/eradicated H. pylori, the number of patients with ulcers in the antimicrobial alone subgroups and antisecretory plus antimicrobial subgroups were similar within each program. Antimicrobials alone had significantly lower rates of ulcers among patients with cleared/eradicated H. pylori as compared with patients without clearance/eradication. Conclusions. The early incidence of duodenal ulcers is significantly decreased in patients with H. pylori clearance/eradication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Helicobacter is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Helicobacter pylori infections
KW - Omeprazole
KW - Ulcers
KW - clinical trials
KW - eradication
KW - lansoprazole
KW - omeprazole
KW - ranitidine-bismuth-citrate
N1 - Accession Number: 4616885; Meyer, Joette M. 1; Silliman, Nancy P. 1; Dixon, Cheryl A. 1; Siepman, Nancy Y. 2; Sugg, Jennifer E. 3; Hopkins, Robert J. 1; Affiliations: 1: Food and Drug Administration, Division of Special Pathogen and Immunologic Drug Products, Rockville, MD;; 2: TAP Pharmaceutical Products Inc., Lake Forest, IL; and; 3: AstraZeneca L.P., Wayne, PA, USA; Issue Info: Jun2001, Vol. 6 Issue 2, p84; Thesaurus Term: Anti-infective agents; Subject Term: Helicobacter pylori infections; Subject Term: Omeprazole; Subject Term: Ulcers; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: eradication; Author-Supplied Keyword: lansoprazole; Author-Supplied Keyword: omeprazole; Author-Supplied Keyword: ranitidine-bismuth-citrate; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1523-5378.2001.00013.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4616885&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Umehara, H
AU - Umehara, Hisanori
AU - Goda, Seiji
AU - Imai, Toshio
AU - Nagano, Yutaka
AU - Minami, Yasuhiro
AU - Tanaka, Yoshiya
AU - Okazaki, Toshiro
AU - Bloom, Eda T
AU - Domae, Naochika
T1 - Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.
JO - Immunology & Cell Biology
JF - Immunology & Cell Biology
Y1 - 2001/06//
VL - 79
IS - 3
M3 - Article
SP - 298
EP - 302
PB - Nature Publishing Group
SN - 08189641
AB - Summary A newly identified CX3C-chemokine, fractalkine, expressed on activated endothelial cells plays an important role in leucocyte adhesion and migration. Co-immobilized fractalkine with fibronectin or intercellular adhesion molecule-1 enhanced adhesion of THP-1 cells, which express the fractalkine receptor (CX3CR1), compared with that observed for each alone. That adherence was fractalkine-dependent and was confirmed in blocking studies. However, soluble fractalkine induced little chemotaxis in THP-1 cells in comparison to monocyte chemotactic protein-1 (MCP-1), which induced a strong chemotactic response. Moreover, the membrane form of fractalkine expressed on ECV304 cells reduced MCP-1 mediated chemotaxis of THP-1 cells. These results indicate that fractalkine may function as an adhesion molecule between monocytes and endothelial cells rather than as a chemotactic factor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology & Cell Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMOKINES
KW - CELL adhesion molecules
KW - CHEMOTAXIS
KW - INTEGRINS
KW - CELL lines
KW - cell adhesion
KW - endothelial cells
KW - fractalkine
KW - integrin
KW - THP-1 cells
N1 - Accession Number: 4564692; Umehara, H; Umehara, Hisanori 1; Goda, Seiji 1; Imai, Toshio 2; Nagano, Yutaka 1; Minami, Yasuhiro 3; Tanaka, Yoshiya 4; Okazaki, Toshiro 5; Bloom, Eda T 6; Domae, Naochika 1; Source Information: Jun2001, Vol. 79 Issue 3, p298; Subject: CHEMOKINES; Subject: CELL adhesion molecules; Subject: CHEMOTAXIS; Subject: INTEGRINS; Subject: CELL lines; Author-Supplied Keyword: cell adhesion; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: fractalkine; Author-Supplied Keyword: integrin; Author-Supplied Keyword: THP-1 cells; Number of Pages: 5p; Document Type: Article
L3 - 10.1046/j.1440-1711.2001.01004.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Vistnes, Jessica P.
AU - Cooper, Philip F.
AU - Vistnes, Gregory S.
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality
AD - Charles River Associates
T1 - Employer Contribution Methods and Health Insurance Premiums: Does Managed Competition Work?
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2001/06//
VL - 1
IS - 2
SP - 159
EP - 187
SN - 13896563
N1 - Accession Number: 0808235; Keywords: Health Insurance; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200512
N2 - We derive a two-stage model in which health plans first compete to be selected by employers and subsequently compete to be chosen by employees. We identify the key determinants of competition and show that increasing competition at one stage often comes at the expense of competition at the other stage. Many economists and policymakers have argued that in order to increase competition among health plans, employers should offer multiple plans and structure premium contributions to make employees more price sensitive. While our theoretical model shows that following this policy prescription may not actually lead to lower premiums, our empirical analysis provides some support for this recommendation. We also find that if employers instead pay the full premium, premiums increase when they offer additional plans. These results have important implications for both employers and policymakers.
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
L3 - http://link.springer.com/journal/volumesAndIssues/10754
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UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106945534
T1 - Trends and outcomes in the hospitalization of older Americans for cardiac conduction disorders or arrhythmias, 1991-1998.
AU - Baine WB
AU - Yu W
AU - Weis KA
Y1 - 2001/06//
N1 - Accession Number: 106945534. Language: English. Entry Date: 20020802. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062.
KW - Aged, Hospitalized -- United States
KW - Arrhythmia -- In Old Age
KW - Hospitalization -- Trends
KW - Outcomes (Health Care) -- In Old Age
KW - United States
KW - Aged
KW - Epidemiological Research
KW - Resource Databases
KW - Female
KW - Male
KW - Patient Discharge
KW - Record Review
KW - Health Facility Costs
KW - Incidence
KW - Descriptive Statistics
KW - Sex Factors
KW - Race Factors
KW - Whites
KW - Blacks
KW - Human
SP - 763
EP - 770
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
VL - 49
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVE: To identify epidemiological trends and measure outcomes in elderly patients hospitalized for cardiac conduction disorders or arrhythmias. DESIGN: Review of the standard 5% samples of the Medicare Provider Analysis and Review Files to characterize 144,512 discharges from 1991 through 1998 in which the principal diagnosis was a conduction disorder or arrhythmia, using the corresponding Enrollment Databases for denominator data. SETTING: Short-stay hospitals in the United States. PARTICIPANTS: Medicare beneficiaries age 65 and older in the standard 5% sample. MEASUREMENTS: Diagnosis-specific trends and rates; discharges by year; cumulative age-, race-, and sex-specific discharge rates; mean length of stay in hospital and in intensive care; mean Medicare reimbursement to the hospital; case-fatality rate in hospital; discharge destinations of patients discharged alive. RESULTS: Annual hospitalizations for sinoatrial node dysfunction, atrial flutter, atrial fibrillation, or ventricular fibrillation increased more rapidly than did the elderly Medicare beneficiary population. Hospitalizations with a principal diagnosis of ventricular extrasystoles or asystole showed steep secular declines. Discharge rates for sinoatrial node dysfunction, a group of rhythms with a nonsinus pacemaker, atrial fibrillation, Mobitz I, or complete atrioventricular block all increased steeply and continuously with patient age. In contrast, discharge rates for atrial flutter or ventricular tachycardia or fibrillation peaked among 75- to 84-year-old patients. White men were at uniquely high risk of hospitalization for atrial flutter or ventricular tachycardia or fibrillation, and, among the white majority, men had higher discharge rates than women for nine of the 11 commonest rubrics. Whites, particularly white women, had the highest discharge rates for atrial fibrillation. Blacks, especially black women, were at disproportionate risk for hospitalization for the group of nonsinus pacemaker rhythms. Diagnosis-specific mean resource costs were strongly correlated with each other and with mean Medicare reimbursement but not with case-fatality rate. CONCLUSION: Medicare claims data demonstrated striking differences among and within diagnoses of heart blocks or arrhythmias in terms of the populations at greatest risk for hospitalization. This variation should be explored further to generate and test hypotheses about differential causation or delivery of care.
SN - 0002-8614
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, 6010 Executive Blvd, Rockville, MD 20852-3813
U2 - PMID: 11454115.
DO - 10.1046/j.1532-5415.2001.49153.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Berg, Cynthia J.
AU - Wilcox, Lynne S.
AU - Philip J. d'Almada, Lynne S.
T1 - The Prevalence of Socioeconomic and Behavioral Characteristics and their Impact on Very Low Birth Weight in Black and White Infants in Georgia.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2001/06//
VL - 5
IS - 2
M3 - Article
SP - 75
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives: We examined possible reasons for the disparity in the rate of very low birth weight (VLBW) delivery (<1500 g) in the United States between black women and white women. Methods: Using data from a population-based, case–control study of very low birth weight infants, we compared the prevalence of sociodemographic and behavioral characteristics between black and white mothers of normal birth weight infants; the difference in these characteristics between case and control mothers; and, using logistic regression, calculated odds ratios for VLBW for black versus white infants, adjusting for these characteristics. Results: Although black women were disadvantaged on every variable examined, they did not report more behavioral risk factors. Among white women, several traditional risk factors were associated with VLBW, while among black women, only marital status, cigarette smoking, and vitamin nonuse were associated with VLBW delivery. Controlling for the socioeconomic and behavioral factors reduced the odds ratio for VLBW delivery among black mothers from 3.7 to 3.3. Conclusions: Racial disparity in socioeconomic status may be greater than our current ability to adjust for it in epidemiologic studies. The fact that traditional risk factors were not associated with VLBW delivery in black women may be due to the very high prevalence of these risk factors among black women or to different or additional risks or stresses experienced by black women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW birth weight
KW - BLACK women
KW - WHITE women
KW - WOMEN -- United States
KW - UNITED States
KW - Georgia
KW - infant
KW - low birth weight
KW - poverty
KW - race
KW - socioeconomic status
N1 - Accession Number: 11307862; Berg, Cynthia J. 1; Email Address: cjb3@cdc.gov; Wilcox, Lynne S. 1; Philip J. d'Almada, Lynne S. 2; Source Information: Jun2001, Vol. 5 Issue 2, p75; Subject: LOW birth weight; Subject: BLACK women; Subject: WHITE women; Subject: WOMEN -- United States; Geographic Terms: UNITED States; Author-Supplied Keyword: Georgia; Author-Supplied Keyword: infant; Author-Supplied Keyword: low birth weight; Author-Supplied Keyword: poverty; Author-Supplied Keyword: race; Author-Supplied Keyword: socioeconomic status; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107060847
T1 - Inequality in America: the contribution of health centers in reducing and eliminating disparities in access to care.
AU - Politzer RM
AU - Yoon J
AU - Shi L
AU - Hughes RG
AU - Regan J
AU - Gaston MH
AU - Politzer, R M
AU - Yoon, J
AU - Shi, L
AU - Hughes, R G
AU - Regan, J
AU - Gaston, M H
Y1 - 2001/06//
N1 - Accession Number: 107060847. Language: English. Entry Date: 20011019. Revision Date: 20170223. Publication Type: journal article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9506850.
KW - Health Services Accessibility
KW - Community Health Services
KW - Health Status
KW - Primary Health Care -- Administration
KW - Quality of Health Care
KW - Poverty
SP - 234
EP - 248
JO - Medical Care Research & Review
JF - Medical Care Research & Review
JA - MED CARE RES REV
VL - 58
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Reducing and eliminating health status disparities by providing access to appropriate health care is a goal of the nation's health care delivery system. This article reviews the literature that demonstrates a relationship between access to appropriate health care and reductions in health status disparities. Using comprehensive site-level data, patient surveys, and medical record reviews, the authors present an evaluation of the ability of health centers to provide such access. Access to a regular and usual source of care alone can mitigate health status disparities. The safety net health center network has reduced racial/ethnic, income, and insurance status disparities in access to primary care and important preventive screening procedures. In addition, the network has reduced low birth weight disparities for African American infants. Evidence suggests that health centers are successful in reducing and eliminating health access disparities by establishing themselves as their patients' usual and regular source of care. This relationship portends well for reducing and eliminating health status disparities.
SN - 1077-5587
AD - Johns Hopkins School of Hygiene and Public Health, USA
AD - Bureau of Primary Health Care, Health Resources and Services Administration, Department of Health and Human Services
U2 - PMID: 11398647.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107060847&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
ID - 107060881
T1 - A new era in opioid dependency treatment. Recent law allows qualified physicians to provide care in office setting.
AU - Clark HW
AU - Clark, H W
Y1 - 2001/06//
N1 - Accession Number: 107060881. Language: English. Entry Date: 20011019. Revision Date: 20161118. Publication Type: editorial; editorial; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0401147.
KW - Substance Use Rehabilitation Programs
KW - Substance Abuse -- Rehabilitation
KW - Recovery
KW - Information Resources
SP - 15
EP - 25
JO - Postgraduate Medicine
JF - Postgraduate Medicine
JA - POSTGRAD MED
VL - 109
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0032-5481
AD - Director, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall 11, Suite 615, 5600 Fishers Ln, Rockville, MD 20857. E-mail: wclark@samhsa.gov
U2 - PMID: 11424343.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107060881&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Haseman, Joseph K.
AU - Bailer, A. John
AU - Kodell, Ralph L.
AU - Morris, Richard
AU - Portier, Ken
T1 - Statistical Issues in the Analysis of Low-Dose Endocrine Disruptor Data.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/06//
VL - 61
IS - 2
M3 - Article
SP - 201
EP - 210
PB - Oxford University Press / USA
SN - 10966080
AB - The National Institute of Environmental Health Sciences (NIEHS) and the U.S. Environmental Protection Agency (U.S. EPA) recently cosponsored the Endocrine Disruptors Low-Dose Peer Review. The purpose of this meeting was to examine data supporting the presence or absence of low-dose effects of endocrine disruptors in specific studies and then to evaluate the likelihood and significance of these and/or other potential low-dose effects for humans. All invited speakers agreed to provide their raw data in advance of the meeting to a Statistics Subpanel, which was asked to reevaluate the authors' experimental design, data analysis, and interpretation of experimental results. The purpose of this statistical reevaluation was to provide an independent assessment of the experimental design and data analysis used in each of the studies and to identify key statistical issues relevant to the evaluation and interpretation of the data. This paper presents a summary of the Statistics Subpanel's evaluation. Specific examples are presented to illustrate problems that arose in the experimental design and data analysis of certain studies. The statistical principles and issues that are discussed in this paper are not unique to endocrine disruptor studies and should provide important guidelines regarding appropriate experimental design and statistical analysis for other types of laboratory investigations. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endocrine disruptors
KW - Estrogen receptors
KW - United States
KW - National Institute of Environmental Health Sciences
KW - United States. Environmental Protection Agency
N1 - Accession Number: 44406160; Haseman, Joseph K. 1; Email Address: haseman@niehs.nih.gov; Bailer, A. John 2; Kodell, Ralph L. 3; Morris, Richard 4; Portier, Ken 5; Affiliations: 1: Biostatistics Branch, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709; 2: Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056-1641; 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079; 4: Analytical Sciences, Inc., Durham, North Carolina 27713; 5: Department of Statistics, University of Florida, Gainesville, Florida 32611-0339; Issue Info: Jun2001, Vol. 61 Issue 2, p201; Thesaurus Term: Endocrine disruptors; Subject Term: Estrogen receptors; Subject: United States ; Company/Entity: National Institute of Environmental Health Sciences ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 10p; Illustrations: 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Joseph, Pius
AU - Muchnok, Timothy K.
AU - Klishis, Michelle L.
AU - Roberts, Jenny R.
AU - Antonini, James M.
AU - Whong, Wen-Zong
AU - Ong, Tong-man
T1 - Cadmium-Induced Cell Transformation and Tumorigenesis Are Associated with Transcriptional Activation of c-fos, c-jun, and c-myc Proto-Oncogenes: Role of Cellular Calcium and Reactive Oxygen Species.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/06//
VL - 61
IS - 2
M3 - Article
SP - 295
EP - 303
PB - Oxford University Press / USA
SN - 10966080
AB - The molecular mechanisms of carcinogenesis by cadmium were studied using BALB/c-3T3 cell transformation and nude mouse tumorigenesis models. BALB/c-3T3 cells transformed with cadmium chloride were subcutaneously injected into nude mice to develop tumors and the cell lines derived from these tumors were used in the present study. The proto-oncogenes c-fos and c-jun were overexpressed in 100% (10 out of 10) of the cell lines, while a statistically significant overexpression of c-myc was observed in 40% (4 out of 10) of the cell lines. Analysis of tumor cells stained with fluorescent dyes specific for reactive oxygen species revealed that these cells possessed markedly higher levels of superoxide anion and hydrogen peroxide compared with the nontransformed cells. Similarly, the intracellular calcium level was higher in the tumor cells compared with the nontransformed cells. Overexpression of the proto-oncogenes in these cells was blocked by treating the cells with superoxide dismutase, catalase, and 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetra acetoxy methyl ester (BAPTA/AM), which are scavengers of superoxide anion, hydrogen peroxide, and calcium, respectively. This confirmed that the overexpression of the proto-oncogenes in the tumor cells required elevated intracellular levels of reactive oxygen species and calcium. In addition to the scavengers of reactive oxygen species and calcium, inhibitors specific for transcription (actinomycin D), protein kinase C (RO-31-8220), and MAP kinase (PD 98059) also blocked the cadmium-induced overexpression of the proto-oncogenes in the tumor cells. Exposure of the nontransformed BALB/c-3T3 cells to 20 μM cadmium chloride for 1 h caused elevated intracellular levels of superoxide anion, hydrogen peroxide, and calcium, with corresponding increases in the expression levels of c-fos, c-jun, and c-myc. As in the case of the tumor cells, treating the nontransformed cells with the various modulators prior to their exposure to cadmium chloride resulted in inhibition in the expression of the proto-oncogenes. Based on these data, we conclude that the cadmium-induced overexpression of cellular proto-oncogenes is mediated by the elevation of intracellular levels of superoxide anion, hydrogen peroxide, and calcium. Further, the cadmium-induced overexpression of the proto-oncogenes is dependent on transcriptional activation as well as on pathways involving protein kinase C and MAP kinase. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cadmium
KW - Carcinogenesis
KW - Calcium
KW - Cell transformation
KW - Gene expression
KW - Active oxygen
KW - cadmium
KW - calcium
KW - carcinogenesis
KW - cell transformation
KW - gene expression
KW - immediate early response genes
KW - reactive oxygen species
N1 - Accession Number: 44406168; Joseph, Pius 1; Email Address: pcj5@cdc.gov; Muchnok, Timothy K. 1; Klishis, Michelle L. 1; Roberts, Jenny R. 2; Antonini, James M. 2; Whong, Wen-Zong 1; Ong, Tong-man 1; Affiliations: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Jun2001, Vol. 61 Issue 2, p295; Thesaurus Term: Cadmium; Thesaurus Term: Carcinogenesis; Thesaurus Term: Calcium; Subject Term: Cell transformation; Subject Term: Gene expression; Subject Term: Active oxygen; Author-Supplied Keyword: cadmium; Author-Supplied Keyword: calcium; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: cell transformation; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: immediate early response genes; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 9p; Illustrations: 4 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jensen, E
AU - Egan, S K
AU - Canady, R A
AU - Bolger, P M
T1 - Dietary exposures to persistent organic pollutants.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 157
EP - 162
PB - Sage Publications, Ltd.
SN - 07482337
AB - As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Applied Nutrition (CFSAN) is primarily interested in POPs as humans may be exposed to these compounds through food. Examples of POPs found in food include dioxins, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers, and some pesticide chemicals. This overview discusses various sources of data that CFSAN has used to estimate dietary exposure to POPs, and provides an example of a recent calculation of an estimate for dietary exposure for consumers in the USA to dioxins in the food supply. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Toxicology
KW - Persistent pollutants
KW - Risk assessment
KW - Dietary exposure assessment
KW - Persistent organic pollutants
N1 - Accession Number: 8974017; Jensen, E 1; Egan, S K 1; Canady, R A 1; Bolger, P M 1; Affiliations: 1: US Food and Drug Administration, HFS-355, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA; Issue Info: 2001, Vol. 17 Issue 5-10, p157; Thesaurus Term: Food -- Toxicology; Thesaurus Term: Persistent pollutants; Thesaurus Term: Risk assessment; Author-Supplied Keyword: Dietary exposure assessment; Author-Supplied Keyword: Persistent organic pollutants; Number of Pages: 6p; Document Type: Article
L3 - 10.1191/0748233701th104oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8974017&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Carrington, Clark D
AU - Bolger, P Michael
T1 - Methods for projecting long-term dietary exposure from short-term survey data for environmental contaminants.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 176
EP - 179
PB - Sage Publications, Ltd.
SN - 07482337
AB - Public health risk assessments often involve dietary exposures over long periods of time. However, most information about dietary consumption habits comes from short-term surveys that are conducted for periods of three days or less. When employed for characterizing long-term exposures, short-term surveys are likely to underestimate the number of persons consuming a particular food, while overestimating the amount consumed by each individual. Direct application of short-term data is particularly misleading for foods that are consumed infrequently. If a more accurate population estimate for chronic dietary intake is needed for a risk assessment, then two general techniques may be considered. The first method is simpler, while the second is more accurate. Both methods require information about the size of the population consuming the food over the long-term period. The simpler fractional adjustment method reduces consumption across the entire distribution by the ratio of consumer population sizes. Since this method will tend to underestimate high-end exposures and overestimate low-end exposures, it is most useful as a quick bounding exercise. Since short-term surveys are better at characterizing the behavior of frequent consumers, a second method employs an exponential function to reduce the low end of the population distribution by a greater amount than the high end. If available, additional information may be used to select the parameter values for the exponential adjustment. Otherwise, an uncertainty range may be used for the parameter values. Since the frequency-based method is more complex, it is most valuable when used as part of a chronic exposure simulation. Examples of both methods are given for the estimation of chronic wine consumption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Toxicology
KW - Pollutants
KW - Health risk assessment
KW - Public health
KW - CHRONIC DIETARY ASSESSMENT
N1 - Accession Number: 8974015; Carrington, Clark D 1; Bolger, P Michael 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: 2001, Vol. 17 Issue 5-10, p176; Thesaurus Term: Food -- Toxicology; Thesaurus Term: Pollutants; Thesaurus Term: Health risk assessment; Thesaurus Term: Public health; Author-Supplied Keyword: CHRONIC DIETARY ASSESSMENT; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
L3 - 10.1191/0748233701th109oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8974015&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wallingford, Kenneth M
AU - Snyder, Erin M
T1 - Occupational exposures during the World Trade Center disaster response.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 247
EP - 253
PB - Sage Publications, Ltd.
SN - 07482337
AB - Upon the request of the New York City Department of Health, the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health (NIOSH) monitored occupational exposures among emergency response workers during the rescue and recovery activities at the World Trade Center disaster site from September 18 through 4 October 2001. During this period, over 1200 bulk and air samples were collected to estimate or characterize workers' occupational exposures. Samples were collected and analyzed for asbestos, carbon monoxide (CO), chlorodifluoromethane (Freon[sup ®] 22), diesel exhaust, hydrogen sulfide, inorganic acids, mercury and other metals, polynuclear aromatic hydrocarbons, respirable particulate not otherwise regulated (PNOR), respirable crystalline silica, total PNOR, and volatile organic compounds. Exposures to most of these potential hazards did not exceed NIOSH Recommended Exposure Limits or Occupational Safety and Health Administration Permissible Exposure Limits. However, one torch cutter was overexposed to cadmium and another worker (and possibly three others) was overexposed to CO. The elevated cadmium and CO levels were the result of workers using oxy-acetylene cutting torches and gasoline-powered cutting saws. Recommendations were made to ensure adequate ventilation and worker understanding when using these tools and, where possible, to substitute rechargeable, battery-powered cutting saws for gasoline-powered ones. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestos
KW - Cadmium
KW - Carbon monoxide
KW - Industrial toxicology
KW - September 11 Terrorist Attacks, 2001
KW - CADMIUM
KW - Occupational exposure
KW - World Trade Center
N1 - Accession Number: 8974029; Wallingford, Kenneth M 1; Snyder, Erin M 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-11), Cincinnati, Ohio 45226, USA; Issue Info: 2001, Vol. 17 Issue 5-10, p247; Thesaurus Term: Asbestos; Thesaurus Term: Cadmium; Thesaurus Term: Carbon monoxide; Thesaurus Term: Industrial toxicology; Subject Term: September 11 Terrorist Attacks, 2001; Author-Supplied Keyword: CADMIUM; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: World Trade Center; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1191/0748233701th112oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8974029&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2001-01638-006
AN - 2001-01638-006
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Sex, ethnicity, age and education effects on the Trail Making test in a sample of cocaine abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/06//
VL - 108
IS - 3-4
SP - 281
EP - 290
CY - US
PB - Gordon & Breach Science Publishers, Inc.
SN - 0020-7454
SN - 1563-5279
N1 - Accession Number: 2001-01638-006. PMID: 11699194 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Informa Healthcare; Taylor & Francis. Release Date: 20010801. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Drug Abuse; Neuropsychological Assessment. Minor Descriptor: Age Differences; Cocaine; Drug Rehabilitation; Education; Human Sex Differences; Racial and Ethnic Differences. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Jun, 2001.
AB - Examined sex, ethnicity, age, and education effects on the Trail Making test (TMT)) in a sample of 5,619 male and 2,902 cocaine/crack abusing patients (mean age 32.6 yrs) enrolled in a national sample of treatment programs. This study involved secondary analysis of data collected as part of the Drug Abuse Treatment Outcome Study from 1991–1993. ANOVA statistical procedures were used to calculate the percentage of variances accounted for by selected demographic variables such as sex and ethnicity. Separate analyses were run for both parts A and B of the TMT. The results show that the variables of sex, age, ethnicity, and education were significant for both parts A and B of the TMT. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex
KW - ethnicity
KW - age
KW - education
KW - Trail Making test
KW - cocaine abuse
KW - crack abuse
KW - treatment programs
KW - 2001
KW - Demographic Characteristics
KW - Drug Abuse
KW - Neuropsychological Assessment
KW - Age Differences
KW - Cocaine
KW - Drug Rehabilitation
KW - Education
KW - Human Sex Differences
KW - Racial and Ethnic Differences
KW - 2001
DO - 10.3109/00207450108986518
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-01638-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-17950-001
AN - 2001-17950-001
AU - MacDonald, L. A.
AU - Karasek, R. A.
AU - Punnett, L.
AU - Scharf, T.
T1 - Covariation between workplace physical and psychosocial stressors: Evidence and implications for occupational health research and prevention.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2001/06//
VL - 44
IS - 7
SP - 696
EP - 718
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
N1 - Accession Number: 2001-17950-001. PMID: 11437204 Partial author list: First Author & Affiliation: MacDonald, L. A.; US Dept of Health & Human Services, Public Health Service, Ctrs for Disease Control & Prevention, National Inst for Occupational Safety & Health, Cincinnati, OH, US. Release Date: 20010606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blue Collar Workers; Occupational Stress; Physiological Stress; Psychological Stress; White Collar Workers. Minor Descriptor: Epidemiology; Human Factors Engineering; Job Characteristics; Working Conditions; Occupational Health. Classification: Human Factors Engineering (4010); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 23. Issue Publication Date: Jun, 2001.
AB - Examined the relationship between physical and psychosocial workplace stressors among 410 blue- (mean age 39.7 yrs) and white-collar (mean age 41.5 yrs) workers employed full-time within a mass production manufacturing environment. Physical stressors were assessed from questionnaire and accelerometry. Psychosocial stressors were assessed from questionnaire. Pearson and Spearman correlation coefficients were computed. An exploratory factor analysis procedure identified possible common factors linking specific physical and psychosocial stressors. Moderate to high correlations between some physical and psychosocial stressors showed evidence of covariation both across and within groups. Covariation was strongest among blue-collar production and low-status office workers. Factor analysis results showed considerable shared variance between some physical and psychosocial stressors, such as repetition and job control, suggesting that these disparate stressors manifest from common work organization factors that govern the structure of work. While recognizing the conceptual differences between physical and psychosocial stressors, these results call attention to the strong empirical relationships that can exist between some stressors in the workplace setting. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ergonomics
KW - psychosocial stressors
KW - physical stressors
KW - covariation
KW - work environment
KW - occupational health
KW - epidemiology
KW - blue-collar workers
KW - white-collar workers
KW - 2001
KW - Blue Collar Workers
KW - Occupational Stress
KW - Physiological Stress
KW - Psychological Stress
KW - White Collar Workers
KW - Epidemiology
KW - Human Factors Engineering
KW - Job Characteristics
KW - Working Conditions
KW - Occupational Health
KW - 2001
DO - 10.1080/00140130110041121
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-17950-001&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-3967-534X
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107073971
T1 - Congestive heart failure associated with itraconazole.
AU - Ahmad SR
AU - Singer SJ
AU - Leissa BG
Y1 - 2001/06/02/
N1 - Accession Number: 107073971. Language: English. Entry Date: 20011207. Revision Date: 20150711. Publication Type: Journal Article; case study; letter; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Itraconazole -- Adverse Effects
KW - Heart Failure -- Chemically Induced
KW - Onychomycosis -- Drug Therapy
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Male
SP - 1766
EP - 1767
JO - Lancet
JF - Lancet
JA - LANCET
VL - 357 North American Edition
IS - 9270
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - Office of Postmarketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, HFD-430, Room 15B-08, 5600 Fishers Lane, Rockville, MD 20857. E-mail: ahmads@cder.fda.gov
U2 - PMID: 11403818.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107073971&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106597506
T1 - Healthcare 'to go' from the VNA of Staten Island.
AU - Belsito LJ
Y1 - 2001/06/04/2001 Jun 4
N1 - Accession Number: 106597506. Language: English. Entry Date: 20050325. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Nursing; USA. NLM UID: 9892044.
KW - Community Health Nursing -- New York
KW - Mobile Health Units -- New York
KW - Preventive Health Care -- New York
KW - New York
SP - 4p
EP - 4p
JO - Nursing Spectrum -- New York & New Jersey Edition
JF - Nursing Spectrum -- New York & New Jersey Edition
JA - NURS SPECTRUM (NY NJ)
VL - 13A
IS - 11
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1081-3101
AD - Public Health Service Commissioned Corps, Division of Immigration and Naturalization, Jamaica, NY
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106597506&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107059167
T1 - Covariation between workplace physical and psychosocial stressors: evidence and implications for occupational health research and prevention.
AU - MacDonald LA
AU - Karasek RA
AU - Punnett L
AU - Scharf T
Y1 - 2001/06/10/
N1 - Accession Number: 107059167. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Stress, Occupational
KW - Stress, Physiological
KW - Stress, Psychological
KW - Industry
KW - Blue Collar Workers
KW - Questionnaires
KW - Accelerometry
KW - Workload Measurement
KW - Job Characteristics
KW - Epidemiological Research
KW - Male
KW - Female
KW - Descriptive Statistics
KW - Adult
KW - Middle Age
KW - Psychological Tests
KW - Coefficient Alpha
KW - Internal Consistency
KW - Wilcoxon Rank Sum Test
KW - Pearson's Correlation Coefficient
KW - Spearman's Rank Correlation Coefficient
KW - Factor Analysis
KW - Data Analysis Software
KW - Peer Pressure -- Evaluation
KW - Human
SP - 696
EP - 718
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 44
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-15, Cincinnati, OH 45226-1998; LMacDonald@cdc.gov
U2 - PMID: 11437204.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107059167&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106959379
T1 - Epidemiologic trends in the hospitalization of elderly Medicare patients for pneumonia, 1991-1998.
AU - Baine WB
AU - Yu W
AU - Summe JP
Y1 - 2001/07//
N1 - Accession Number: 106959379. Language: English. Entry Date: 20020913. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Hospitalization -- Trends -- In Old Age
KW - Medicare -- Trends
KW - Pneumonia -- Epidemiology -- In Old Age
KW - Pneumonia -- Therapy -- In Old Age
KW - Epidemiological Research
KW - Descriptive Research
KW - Descriptive Statistics
KW - International Classification of Diseases
KW - P-Value
KW - Age Factors
KW - Sex Factors
KW - Pneumonia, Aspiration -- Epidemiology -- In Old Age
KW - Pneumonia -- Diagnosis
KW - Insurance, Health, Reimbursement
KW - Blacks
KW - Whites
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 1121
EP - 1123
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 91
IS - 7
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study determined hospitalization rates of elderly Americans for pneumonia from 1991 through 1998. METHODS: Epidemiologic data were described for 273,143 pneumonia hospitalizations. RESULTS: Annual hospitalizations for aspiration pneumonia increased by 93.5%. Pneumonia hospitalization rates increased steeply with age, especially among men. Black men were at highest risk for aspiration, unspecified, Klebsiella, 'other gram-negative,' and staphylococcal pneumonia; White men had the highest Haemophilus and pneumococcal pneumonia rates. Among women, Blacks predominated in aspiration and Klebsiella pneumonia; Whites had the highest Haemophilus and bronchopneumonia rates. CONCLUSIONS: An epidemic of hospitalization for aspiration pneumonia smoldered over 8 years. Significant disparities existed in hospitalization risks by race, sex, and principal diagnosis.
SN - 0090-0036
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, 6010 Executive Blvd, Rockville, MD 20852-3813 (wbaine@ahrq.gov)
U2 - PMID: 11441742.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106959379&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bartley, David L.
T1 - Definition and Assessment of Sampling and Analytical Accuracy.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2001/07//
VL - 45
IS - 5
M3 - Article
SP - 357
EP - 364
SN - 00034878
AB - Two independent definitions for quantifying measurement accuracy and two limiting schemes for their assessment are examined in this paper. Gauss' mean square error MSE is compared to the symmetric-range accuracy A, describing the range of measurements about a measurand. Both measures of accuracy account for systematic error (bias) and imprecision so as to quantify the closeness of estimates to the actual values being measured. Remarkably, it is found that the accuracy functions are closely equivalent for most method applications. Furthermore, details are presented on how to compute confidence limits on measurement accuracy so as to account for error in method evaluation. The confidence limits are qualitatively different in the case that the method undergoes extensive initial evaluation in comparison to a continual re-evaluation at each method application. To this end the statistical theories of tolerance as well as more familiar types of confidence intervals are applied. Published by Elsevier Science Ltd on behalf of British Occupational Hygiene Society. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Sampling (Statistics)
KW - Sample variance
KW - Confidence intervals
KW - Statistical bias
KW - Error rates
KW - Error analysis (Mathematics)
KW - Data corruption
KW - Statistical tolerance regions
KW - accuracy
KW - confidence
KW - performance
KW - tolerance
KW - uncertainty
N1 - Accession Number: 45226824; Bartley, David L. 1; Email Address: dbartley@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; Issue Info: Jul2001, Vol. 45 Issue 5, p357; Thesaurus Term: Industrial hygiene; Subject Term: Sampling (Statistics); Subject Term: Sample variance; Subject Term: Confidence intervals; Subject Term: Statistical bias; Subject Term: Error rates; Subject Term: Error analysis (Mathematics); Subject Term: Data corruption; Subject Term: Statistical tolerance regions; Author-Supplied Keyword: accuracy; Author-Supplied Keyword: confidence; Author-Supplied Keyword: performance; Author-Supplied Keyword: tolerance; Author-Supplied Keyword: uncertainty; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tucker, Geoffrey T.
AU - Houston, J. Brian
AU - Huang, Shiew-Mei
T1 - Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus.
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
Y1 - 2001/07//
VL - 52
IS - 1
M3 - Article
SP - 107
EP - 117
SN - 03065251
AB - Summarizes the outcomes of a drug development conference held in Basel, Switzerland in November 2000 which attempted to develop a consensus on the conduct of in vitro and in vivo studies of metabolic and transport interactions. Complexities and standardization of in vitro studies; Priorities for transporter research; In vitro predictive model; Regulatory requirements for the evaluation of drug-drug interactions.
KW - DRUG development
KW - DRUG metabolism
KW - CONFERENCES & conventions
KW - SWITZERLAND
KW - BASEL (Switzerland)
N1 - Accession Number: 4821212; Tucker, Geoffrey T. 1; Houston, J. Brian 2; Huang, Shiew-Mei 3; Source Information: Jul2001, Vol. 52 Issue 1, p107; Subject: DRUG development; Subject: DRUG metabolism; Subject: CONFERENCES & conventions; Geographic Terms: SWITZERLAND; BASEL (Switzerland); Number of Pages: 11p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article; Full Text Word Count: 6805
L3 - 10.1046/j.0306-5251.2001.Temp.1441.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=4821212&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Matheson, J. M.
AU - Lange, R. W.
AU - Lemus, R.
AU - Karol, M. H.
AU - Luster, M. I.
T1 - Importance of inflammatory and immune components in a mouse model of airway reactivity to toluene diisocyanate (TDI).
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2001/07//
VL - 31
IS - 7
M3 - Article
SP - 1067
EP - 1076
PB - Wiley-Blackwell
SN - 09547894
AB - Background Nearly 9 million individuals are exposed to agents in the workplace associated with asthma, and isocyanates represent the most common cause of occupationally induced asthma. Objectives Nonetheless, the immunological mechanisms responsible for isocyanate-induced asthma are not clear. A murine model for toluene diisocyanate (TDI) asthma is described and employed to examine inflammatory and immune components that may be involved in the disease. Methods Groups (n = 6) of C57BL/6J and athymic mice were sensitized by subcutaneous injection (20 µl on day 1, 5 µl on days 4 and 11), and 7 days later challenged by inhalation (100 p.p.b., days 20, 22 and 24) with TDI. Twenty-four hours following the last challenge the tracheae and lungs were examined for histological changes as well as for the expression of Th1, Th2 and pro-inflammatory cytokines. Mice were also examined for airway reactivity to methacholine challenge and for specific and total IgE and IgG antibodies. Results TDI sensitization resulted in increased reactivity to methacholine challenge as well as a significant inflammatory response in the trachea and nares of wild-type mice, but not in the athymic mice nor in the lungs of the C57BL/6J mice. Airway inflammation was characterized by inflammatory cell influx, goblet cell metaplasia and epithelial damage. Histological changes in the trachea were accompanied by increased mRNA expression of interleukin (IL)-4, tumour necrosis factor α, lymphotoxin β, lymphotactin and Rantes, as well as TDI-specific IgG antibodies and elevated levels of total IgE. IgE-specific antibodies were not detected with this exposure regimen but were produced when the TDI concentrations were increased. Conclusions These studies provide a unique murine model for occupational asthma that generates both inflammatory and immune mediators similar to those occurring in TDI-induced asthma in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Allergy
KW - Isocyanates
KW - Respiratory allergy
KW - Airway hypersensitivity
KW - occupational asthma
KW - Toluene diisocyanate
N1 - Accession Number: 4821243; Matheson, J. M. 1; Lange, R. W. 2; Lemus, R. 3; Karol, M. H. 3; Luster, M. I. 1; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia,; 2: Pathology and Toxicology, 3M Pharmaceuticals, St Paul, Minnesota,; 3: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Issue Info: Jul2001, Vol. 31 Issue 7, p1067; Thesaurus Term: Asthma; Thesaurus Term: Allergy; Subject Term: Isocyanates; Subject Term: Respiratory allergy; Author-Supplied Keyword: Airway hypersensitivity; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: Toluene diisocyanate; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1046/j.1365-2222.2001.01125.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=4821243&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106952323
T1 - The impact of age, gender, and race on the relationship between depression and self-rated health in community-dwelling older adults: a longitudinal study.
AU - Han B
Y1 - 2001/07//
N1 - Accession Number: 106952323. Language: English. Entry Date: 20020823. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). NLM UID: 8000128.
KW - Depression -- Epidemiology -- In Old Age
KW - Health Status -- In Old Age
KW - Age Factors
KW - Sex Factors
KW - Race Factors
KW - Prospective Studies
KW - Self Report
KW - Blacks
KW - Whites
KW - Geriatric Functional Assessment
KW - Center for Epidemiological Studies Depression Scale
KW - Neuropsychological Tests
KW - Descriptive Statistics
KW - Multiple Logistic Regression
KW - Data Analysis, Statistical
KW - Data Analysis Software
KW - Odds Ratio
KW - Confidence Intervals
KW - P-Value
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 27
EP - 43
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 20
IS - 3
PB - Taylor & Francis Ltd
AB - Objective: To examine whether the prediction of baseline depression for subsequent changes in self-rated health is consistent across different age cohorts, gender, and racial groups.Data Sources and Study Setting: A total of 6,714 participants who were 65 years old or older and took part in both the first and the second wave of Assets and Health Dynamics among the Oldest-Old (AHEAD) national survey of community-dwelling older adults were examined.Study Design: A two-year prospective cohort study.Principle Findings: Baseline depression was an independent risk factor, which not only decreased the odds of having substantial improvement in self-rated health but also increased the possibility of having substantial decline in self-rated health in older men and women, and in Blacks and Whites of all age groups.Conclusions: Early prevention and treatment of depression among community-dwelling older adults may not only reduce their health decline but also promote their health.
SN - 0162-1424
AD - Special Populations Research Branch, Division of Programs for Special Populations, Bureau of Primary Health Care, Health Resources and Service Administration, 4350 East-West Highway, Room 9-3A1, Bethesda, MD 20814; bhan@hrsa.gov
U2 - PMID: 12018684.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106952323&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106952338
T1 - Overexertion injuries in home health care workers and the need for ergonomics.
AU - Galinsky T
AU - Waters T
AU - Malit B
Y1 - 2001/07//
N1 - Accession Number: 106952338. Language: English. Entry Date: 20020823. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128.
KW - Home Health Care -- Adverse Effects
KW - Cumulative Trauma Disorders -- Epidemiology
KW - Cumulative Trauma Disorders -- Prevention and Control
KW - Ergonomics -- Trends
KW - Lifting -- Adverse Effects
KW - Occupational-Related Injuries -- Prevention and Control
KW - Occupational-Related Injuries -- Epidemiology
KW - Back Injuries -- Prevention and Control
KW - Lifting and Transfer Equipment
SP - 57
EP - 73
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 20
IS - 3
PB - Taylor & Francis Ltd
AB - Home health care workers have high rates of back injuries and other musculoskeletal problems. This article addresses issues surrounding work-related overexertion injuries in home health care workers, including summaries of relevant research on workers in home settings as well as in traditional health care settings such as hospitals and nursing homes. The main work factors associated with these injuries are forceful exertions and awkward postures during patient- care tasks, especially while lifting and moving patients. Ergonomics-the design of work tasks to best accommodate natural human capabilities-is the most promising approach for preventing injuries, and for enhancing the comfort and safety of workers and patients.
SN - 0162-1424
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop C-24, Cincinnati, OH 45226; tgallinsky@cdc.gov
U2 - PMID: 12018686.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106952338&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106903769
T1 - From the Food and Drug Administration. Cardiac perforation and tamponade: the deadly duo of central venous catheters.
AU - Yoder D
Y1 - 2001/07//2001 Jul-Sep
N1 - Accession Number: 106903769. Language: English. Entry Date: 20020301. Revision Date: 20150820. Publication Type: Journal Article; case study; statistics; tables/charts; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Central Venous Catheters -- Adverse Effects
KW - Cardiac Tamponade
KW - Heart Injuries
KW - World Wide Web
KW - Voluntary Reporting
KW - United States Food and Drug Administration
KW - Cardiac Tamponade -- Mortality
KW - Cardiac Tamponade -- Diagnosis
KW - Cardiac Tamponade -- Prevention and Control
KW - Cardiac Tamponade -- Therapy
KW - Cardiac Tamponade -- Symptoms
KW - Heart Injuries -- Mortality
KW - Heart Injuries -- Diagnosis
KW - Heart Injuries -- Prevention and Control
KW - Heart Injuries -- Therapy
KW - Heart Injuries -- Symptoms
KW - Infant, Newborn
KW - Child, Preschool
KW - Adult
SP - 108
EP - 112
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 7
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Nurse Consultant, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr, Rockville, MD 20850. E-mail: dyb@cdrh.fda.gov
U2 - PMID: 11477392.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106903769&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Encinosa, William
T1 - A comment on Neudeck and Podczeck's "adverse selection and regulation in health insurance markets".
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2001/07//
VL - 20
IS - 4
M3 - Article
SP - 667
EP - 673
SN - 01676296
AB - Using the Grossman equilibrium concept, Neudeck and Podczeck [Journal of Health Economics 15 (1996) 387] show that imposing a minimum standard on a perfectly competitive insurance market can result in anti-competitive effects: decreased welfare with some insurers earning positive profits. However, the Grossman concept precludes an insurer from offering two separating, cross-subsidizing health plans. When an insurer can offer multiple plans (as under both the Nash and Miyazaki-Wilson equilibrium concepts), I show that minimum standards result in a doubleton equilibrium, never allow positive total profits, and increase welfare. This is of interest since in 1997 more than half of establishments in the U.S. offering choice of multiple plans did so through a single insurer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - EQUILIBRIUM (Economics)
KW - DELEGATED legislation
KW - WELFARE economics
KW - PROFIT
KW - UNITED States
KW - Adverse selection
KW - Health insurance minimum standards
KW - Regulation
N1 - Accession Number: 11948060; Encinosa, William 1; Email Address: wencinos@ahrq.gov; Source Information: Jul2001, Vol. 20 Issue 4, p667; Subject: HEALTH insurance; Subject: EQUILIBRIUM (Economics); Subject: DELEGATED legislation; Subject: WELFARE economics; Subject: PROFIT; Geographic Terms: UNITED States; Author-Supplied Keyword: Adverse selection; Author-Supplied Keyword: Health insurance minimum standards; Author-Supplied Keyword: Regulation; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 107043191
T1 - Device safety. Preventing problems from tampon use.
AU - Swayze SC
Y1 - 2001/07//
N1 - Accession Number: 107043191. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Tampons -- Adverse Effects
KW - Toxic Shock Syndrome
KW - Patient Education
SP - 28
EP - 28
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107043191&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107059252
T1 - Evidence-based practices for services to families of people with psychiatric disabilities.
AU - Dixon L
AU - McFarlane WR
AU - Lefley H
AU - Lucksted A
AU - Cohen M
AU - Falloon I
AU - Mueser K
AU - Miklowitz D
AU - Solomon P
AU - Sondheimer D
Y1 - 2001/07//
N1 - Accession Number: 107059252. Language: English. Entry Date: 20011012. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Professional Practice, Evidence-Based -- Methods
KW - Family -- Psychosocial Factors
KW - Health Education
KW - Mental Disorders -- Therapy
KW - Mental Health Services -- Standards
KW - Health Education -- Standards
KW - Mental Disorders -- Psychosocial Factors
KW - United States
SP - 903
EP - 910
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 52
IS - 7
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Family psychoeducation is an evidence-based practice that has been shown to reduce relapse rates and facilitate recovery of persons who have mental illness. A core set of characteristics of effective family psychoeducation programs has been developed, including the provision of emotional support, education, resources during periods of crisis, and problem-solving skills. Unfortunately, the use of family psychoeducation in routine practice has been limited. Barriers at the level of the consumer and his or her family members, the clinician and the administrator, and the mental health authority reflect the existence of attitudinal, knowledge-based, practical, and systemic obstacles to implementation. Family psychoeducation dissemination efforts that have been successful to date have built consensus at all levels, including among consumers and their family members; have provided ample training, technical assistance, and supervision to clinical staff; and have maintained a long-term perspective.
SN - 1075-2730
AD - Center for Mental Health Services Research, University of Maryland School of Medicine, Baltimore, MD
U2 - PMID: 11433107.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107059252&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106976537
T1 - An analysis of physician antitrust exemption legislation: adjusting the balance of power.
AU - Hellinger FJ
AU - Young GJ
AU - Hellinger, F J
AU - Young, G J
A2 - Gostin LO
A2 - Cole HM
Y1 - 2001/07/04/
N1 - Accession Number: 106976537. Language: English. Entry Date: 20021108. Revision Date: 20161112. Publication Type: journal article. Commentary: Foreman S, Emmons D, Wozniak G. Economic consequences of collective bargaining by physicians. (JAMA) 10/17/2001; 286 (15): 1837-1839. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Managed Care Programs
KW - Antitrust -- Legislation and Jurisprudence -- United States
KW - Physicians -- Legislation and Jurisprudence -- United States
KW - Collective Bargaining -- Legislation and Jurisprudence
KW - Joint Ventures
KW - United States
KW - Professional Practice
KW - Economic Competition
SP - 83
EP - 88
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 286
IS - 1
CY - Chicago, Illinois
PB - American Medical Association
AB - Current antitrust law restricts physicians from joining together to collectively negotiate. However, such activities may be approved by state laws under the so-called state action immunity doctrine and by federal legislation under an explicit antitrust exemption. In 1999, Texas became the first state to pass physician antitrust exemption legislation allowing physicians, under certain defined circumstances, to collectively negotiate fees with health plans. Last year, similar legislation was introduced in the US Congress, in 18 state legislatures, and in the District of Columbia. This legislation was passed only in the District of Columbia where its implementation was blocked by the city's financial control board. Nonetheless, legislation permitting physicians to collectively negotiate fees with managed care plans has been introduced in 10 state legislatures this year, and there is continued interest in introducing similar legislation in the US Congress. This analysis examines the basic features of this legislation and its potential impact on the balance of power between physicians and managed care plans.
SN - 0098-7484
AD - Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Suite 605, 2101 E Jefferson St, Rockville, MD 20852, USA
AD - Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Suite 605, 2101 E Jefferson St, Rockville, MD 20852; fhelling@ahrq.gov
U2 - PMID: 11434831.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106976537&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
ID - 89130208
T1 - Developing drugs to decrease the toxicity of chemotherapy.
AU - Williams, Grant
AU - Cortazar, Patricia
AU - Pazdur, Richard
AU - Batist, Gerald
AU - Welles, Lauri
AU - Williams, G
AU - Cortazar, P
AU - Pazdur, R
Y1 - 2001/07/15/
N1 - Accession Number: 89130208. Language: English. Entry Date: 20020111. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Antineoplastic Agents -- Adverse Effects
KW - Drugs, Investigational
KW - Antineoplastic Agents -- Administration and Dosage
KW - Breast Neoplasms -- Drug Therapy
KW - Doxorubicin -- Administration and Dosage
KW - Heart -- Drug Effects
KW - Membranes, Artificial
KW - Heterocyclic Compounds -- Therapeutic Use
KW - Doxorubicin -- Adverse Effects
KW - Clinical Trials
SP - 3439
EP - 3441
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 14
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - United States Food and Drug Administration, Rockville, MD
AD - Jewish General Hospital, McGill University, Montreal, Canada
AD - Elan Pharmaceuticals, Princeton, NJ
U2 - PMID: 11454894.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=89130208&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Crespo, Carlos J.
AU - Smit, Ellen
AU - Carter-Pokras, Olivia
AU - Andersen, Ross
T1 - Acculturation and Leisure-Time Physical Inactivity in Mexican American Adults: Results From NHANES III, 1988-1994.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/08//
VL - 91
IS - 8
M3 - Article
SP - 1254
EP - 1257
PB - American Public Health Association
SN - 00900036
AB - Conclusions. Acculturation seems to be positively associated with participation in leisure-time physical activity. (Am J Public Health. 2001;91:1254-1257) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Acculturation
KW - Leisure
KW - Hypokinesia
KW - Mexican Americans
KW - National health services
KW - Health surveys -- United States
KW - United States
N1 - Accession Number: 4905216; Crespo, Carlos J. 1; Email Address: ccrespo@buffalo.edu; Smit, Ellen; Carter-Pokras, Olivia 2; Andersen, Ross 3; Affiliations: 1: School of Medicine and Biomedical Sciences, State University of New York, Buffalo; 2: Office of Minority Health, US Department of Health and Human Services, Washington, DC; 3: School of Medicine, Johns Hopkins University, Baltimore; Issue Info: Aug2001, Vol. 91 Issue 8, p1254; Thesaurus Term: Public health; Subject Term: Acculturation; Subject Term: Leisure; Subject Term: Hypokinesia; Subject Term: Mexican Americans; Subject Term: National health services; Subject Term: Health surveys -- United States; Subject: United States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 2418
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cha, C.-J.
T1 - Biological production of optically active muconolactones by Rhodococcus rhodochrous.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2001/08//
VL - 56
IS - 3/4
M3 - Article
SP - 453
EP - 457
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Optically active (-)-3-methylmuconolactone was biologically produced using a mutant strain of Rhodococcus rhodochrous N75 that is capable of metabolizing 4-methylcatechol via a modified ortho-cleavage pathway. The mutant strain (CJ30) was prepared by mutagenesis using N-methyl-N'-nitro-N-nitrosoguanidine and found to be blocked in the degradation of 3-methylmuconolactone. Cells of the mutant CJ30, which had been previously grown on yeast extract and induced with p-toluate, transformed p-toluate (11.5 mM) to optically active (-)-3-methylmuconolactone with a yield of 53%. The structure of 3-methylmuconolactone was confirmed by NMR spectroscopy and mass spectrometry. Cell-free extracts of R. rhodochrous N75 also transformed a range of 4-alkylcatechols, such as 4-ethylcatechol, 4-iso-propylcatechol, and 4-tert-butylcatechol, to the corresponding 4-alkyl-substituted muconolactones. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Organic cyclic compounds
KW - Methyl ether
KW - Lactones
KW - Guaiacol
KW - Guanidine
N1 - Accession Number: 15680840; Cha, C.-J. 1,2; Email Address: ccha@nctr.fda.gov; Affiliations: 1: Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK; 2: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Aug2001, Vol. 56 Issue 3/4, p453; Thesaurus Term: Organic cyclic compounds; Thesaurus Term: Methyl ether; Subject Term: Lactones; Subject Term: Guaiacol; Subject Term: Guanidine; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1007/s002530100668
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parshikov, I. A.
AU - Heinze, T. M.
AU - Moody, J. D.
AU - Freeman, J. P.
AU - Williams, A. J.
AU - Sutherland, J. B.
T1 - The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2001/08//
VL - 56
IS - 3/4
M3 - Article
SP - 474
EP - 447
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - The metabolism of the fluoroquinolone drugs ciprofloxacin and norfloxacin by Pestalotiopsis guepini strain P-8 was investigated. Cultures were grown at 28 °C in sucrose/peptone broth for 18 days after dosing with ciprofloxacin (300 µM) or norfloxacin (313 µM). Four major metabolites were produced from each drug; and these were purified by high-performance liquid chromatography and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Ciprofloxacin metabolites included N-acetylciprofloxacin (52.0%), desethylene-N-acetylciprofloxacin (9.2%), N-formylciprofloxacin (4.2%), and 7-amino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (2.3%). Norfloxacin metabolites included N-acetylnorfloxacin (55.4%), desethylene-N-acetylnorfloxacin (8.8%), N-formylnorfloxacin (3.6%), and 7-amino-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (2.1%). N-Formylciprofloxacin and the four transformation products from norfloxacin are all known to be mammalian metabolites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungi
KW - Parasitic plants
KW - Quinolone antibacterial agents
KW - Ciprofloxacin
KW - Norfloxacin
N1 - Accession Number: 15680862; Parshikov, I. A. 1; Heinze, T. M. 2; Moody, J. D. 1; Freeman, J. P. 2; Williams, A. J. 1; Sutherland, J. B. 1; Email Address: jsutherland@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; 2: Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Aug2001, Vol. 56 Issue 3/4, p474; Thesaurus Term: Fungi; Thesaurus Term: Parasitic plants; Thesaurus Term: Quinolone antibacterial agents; Subject Term: Ciprofloxacin; Subject Term: Norfloxacin; Number of Pages: 4p; Illustrations: 2 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s002530100672
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15680862&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Duydu, Y.
AU - Süzen, H. S.
AU - Aydin, A.
AU - Cander, O.
AU - Uysal, H.
AU - Işimer, A.
AU - Vural, N.
T1 - Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers.
JO - Archives of Environmental Contamination & Toxicology
JF - Archives of Environmental Contamination & Toxicology
Y1 - 2001/08//
VL - 41
IS - 2
M3 - Article
SP - 241
EP - 246
PB - Springer Science & Business Media B.V.
SN - 00904341
AB - Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lead -- Toxicology
KW - Environmental toxicology
KW - Sister chromatid exchange
KW - Lymphocytes
KW - Employees
KW - Battery industry
N1 - Accession Number: 15668770; Duydu, Y. 1; Email Address: duydu@pharmacy.ankara.edu.tr; Süzen, H. S. 1; Aydin, A. 2; Cander, O. 3; Uysal, H. 3; Işimer, A. 2; Vural, N. 1; Affiliations: 1: University of Ankara, Faculty of Pharmacy, Department of Toxicology, 06100, Tandogan, Ankara, Turkey; 2: Gülhane Military Medical Academy, Department of Pharmaceutical Toxicology, Ankara, Turkey; 3: The National Institute of Occupational Safety and Health, Etimesgut, Ankara, Turkey; Issue Info: Aug2001, Vol. 41 Issue 2, p241; Thesaurus Term: Lead -- Toxicology; Thesaurus Term: Environmental toxicology; Subject Term: Sister chromatid exchange; Subject Term: Lymphocytes; Subject Term: Employees; Subject Term: Battery industry; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 335910 Battery manufacturing; NAICS/Industry Codes: 335911 Storage Battery Manufacturing; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/s002440010244
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Riviere, Jim E.
AU - Qiao, Guilin
AU - Baynes, Ronald E.
AU - Brooks, James D.
AU - Mumtaz, Moiz
T1 - Mixture component effects on the in vitro dermal absorption of pentachlorophenol.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2001/08//
VL - 75
IS - 6
M3 - Article
SP - 329
EP - 334
PB - Springer Science & Business Media B.V.
SN - 03405761
AB - Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal risk assessment process, would be greatly improved by the elucidation and characterization of these interactions. Pentachlorophenol (PCP), a compound known to penetrate the skin readily, was used as a marker compound to examine mixture component effects using in vitro porcine skin models. PCP was administered in ethanol or in a 40% ethanol/60% water mixture or a 40% ethanol/60% water mixture containing either the rubefacient methyl nicotinate (MNA) or the surfactant sodium lauryl sulfate (SLS), or both MNA and SLS. Experiments were also conducted with 14C-labelled 3,3',4,4'-tetrachlorobiphenyl (TCB) and 3,3',4,4',5-pentachlorobiphenyl (PCB). Maximal PCP absorption was 14.12% of the applied dose from the mixture containing SLS, MNA, ethanol and water. However, when PCP was administered in ethanol only, absorption was only 1.12% of the applied dose. There were also qualitative differences among the absorption profiles for the different PCP mixtures. In contrast with the PCP results, absorption of TCB or PCB was negligible in perfused porcine skin, with only 0.14% of the applied TCB dose and 0.05% of the applied PCB dose being maximally absorbed. The low absorption levels for the PCB congeners precluded the identification of mixture component effects. These results suggest that dermal absorption estimates from a single chemical exposure may not reflect absorption seen after exposure as a chemical mixture and that absorption of both TCB and PCB are minimal in this model system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Alcohol
KW - Biphenyl compounds
KW - Polychlorinated biphenyls
KW - Dermatotoxicology
KW - Cutaneous manifestations of general diseases
KW - Basal cell nevus syndrome
KW - Absorption
KW - Dermal
KW - Mixtures
KW - Pentachlorophenol
KW - Polychlorinated biphenyl
N1 - Accession Number: 15731824; Riviere, Jim E. 1; Email Address: Jim_Riviere@NCSU.EDU; Qiao, Guilin 1,2; Baynes, Ronald E. 1; Brooks, James D. 1; Mumtaz, Moiz 3; Affiliations: 1: Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606, USA; 2: EAB/HELD, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA; 3: Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA, USA; Issue Info: Aug2001, Vol. 75 Issue 6, p329; Thesaurus Term: Risk assessment; Thesaurus Term: Alcohol; Thesaurus Term: Biphenyl compounds; Thesaurus Term: Polychlorinated biphenyls; Thesaurus Term: Dermatotoxicology; Subject Term: Cutaneous manifestations of general diseases; Subject Term: Basal cell nevus syndrome; Author-Supplied Keyword: Absorption; Author-Supplied Keyword: Dermal; Author-Supplied Keyword: Mixtures; Author-Supplied Keyword: Pentachlorophenol; Author-Supplied Keyword: Polychlorinated biphenyl; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/s002040100242
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jinneman, Karen C.
AU - Hill, Walter E.
T1 - Listeria monocytogenes Lineage Group Classification by MAMA-PCR of the Listeriolysin Gene.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 2001/08//
VL - 43
IS - 2
M3 - Article
SP - 129
EP - 133
PB - Springer Science & Business Media B.V.
SN - 03438651
AB - Nucleotide sequence differences within several virulence genes, including the listeriolysin O (hly) gene, are associated with three evolutionary lineage groups of Listeria monocytogenes. Because the ability of L. monocytogenes to cause disease may vary by evolutionary lineage group, rapid discrimination among the three lineage types may be important for estimating pathogenic potential. A Mismatch Amplification Mutation Assay (MAMA) was developed and used to rapidly screen and characterize L. monocytogenes isolates with regard to lineage type. A standard PCR amplified a 446-bp region within the hly gene with all three L. monocytogenes lineage genotypes. MAMA primers to four different sites within this region of the hly gene were designed to amplify under the same PCR conditions and generated amplicons, the size of which depended on the isolate genotype. Ninety-seven L. monocytogenes isolates were screened. All isolates, except ATCC 19116, could be classified by MAMA PCR as one of the three hly genotypes. Overall, 56, 36, and 4 of the 97 isolates tested were type 1, 2, or 3 respectively. Among the 26 patient isolates, 85%, 15%, and 0% were type 1, 2, or 3 respectively; for the 60 food isolates, 54% were type 1, 43% were type 2, and 3% were type 3. The combination of these MAMA PCR analyses provides a rapid method to screen and categorize L. monocytogenes isolates because of conserved nucleotide differences within the hly gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Current Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Nucleotide sequence
KW - Listeria monocytogenes
KW - Genes
KW - Nucleotides -- Analysis
KW - Nucleic acids -- Analysis
N1 - Accession Number: 15312225; Jinneman, Karen C. 1; Hill, Walter E. 1; Affiliations: 1: Seafood Products Research Center, Pacific Regional Laboratory-Northwest, Food and Drug Administration, 22201 23rd Dr. SE,, Bothell, WA 98021-4421, USA.; Issue Info: Aug2001, Vol. 43 Issue 2, p129; Thesaurus Term: Mutation (Biology); Subject Term: Nucleotide sequence; Subject Term: Listeria monocytogenes; Subject Term: Genes; Subject Term: Nucleotides -- Analysis; Subject Term: Nucleic acids -- Analysis; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/s002840010274
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107073495
T1 - Implantable middle ear hearing devices: a regulatory perspective.
AU - Baker KH
Y1 - 2001/08//2001 Aug
N1 - Accession Number: 107073495. Language: English. Entry Date: 20020503. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 8406451.
KW - Ear, Middle
KW - Prostheses and Implants -- Standards
KW - Hearing Aids -- Trends
KW - Government Regulations
KW - United States Food and Drug Administration
KW - Clinical Trials
KW - Product Evaluation
SP - 36
EP - 37
JO - Hearing Journal
JF - Hearing Journal
JA - HEAR J
VL - 54
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0745-7472
AD - Nurse Consultant, Ear, Nose and Throat Devices Branch, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Toraason, Mark
AU - Hayden, Charles
AU - Marlow, Dave
AU - Rinehart, Richard
AU - Mathias, Patty
AU - Werren, Dwight
AU - DeBord, D. Gayle
AU - Reid, Thomas M.
T1 - DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2001/08//
VL - 74
IS - 6
M3 - Article
SP - 396
EP - 404
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Objective: To determine the potential for asphalt fume exposure to increase DNA damage, we conducted a cross-sectional study of roofers involved in the application of roofing asphalt. Methods: DNA strand breaks and the ratio of 8-hydroxydeoxyguanosine (8-OHdG) to 2-deoxyguanosine (dG) were measured in peripheral blood leukocytes of roofers. In addition, urinary excretion of 8-OHdG and 8-epi-prostaglandin F2α (8-epi-PGF) was also measured. The study population consisted of 26 roofers exposed to roofing asphalt and 15 construction workers not exposed to asphalt during the past 5 years. A subset of asphalt roofers (n=19) was exposed to coal-tar pitch dust (coal tar) during removal of existing roofs prior to applying hot asphalt. Personal air monitoring was performed for one work-week to measure exposure to total particulates, benzene-soluble fraction of total particulates, and polycyclic aromatic compounds (PACs). Urinary 1-OH-pyrene levels were measured as an internal biomarker of PAC exposure. Results: Full-shift breathing zone measurements for total particulates, benzene-solubles and PACs were significantly higher for coal-tar exposed workers than for roofers not exposed to coal tar. Similarly, urinary 1-OH-pyrene levels were higher in coal-tar exposed roofers than roofers not exposed to coal tar. Total particulates or benzene-soluble fractions were not associated with urinary 1-OH-pyrene, but PAC exposure was highly correlated with urinary 1-OH-pyrene. When stratified by 1-OH-pyrene excretion, DNA strand breaks increased in a dose-dependent manner, and leukocyte 8-OHdG/dG decreased in a dose-dependent manner. Significant changes in DNA damage appeared to be linked to PACs from coal-tar exposure, although asphalt fume alone was associated with a small but significant increase in urinary 1-OH-pyrene and DNA strand breaks. Conclusions: Results are consistent with previous reports that asphalt or coal-tar exposure can cause DNA damage. Urinary 8-epi-PGF remained relatively constant during the week for virtually all subjects, regardless of exposure indicating that neither asphalt nor coal-tar exposure induces an overt oxidative stress. A small, but statistically significant increase in 8OHdG was evident in end-of-week urine samples compared with start-of-week urine samples in roofers exposed to coal-tar. The increase in urinary 8OHdG coupled with the decrease in leukocyte 8-OHdG/dG, suggests that coal-tar exposure induces protective or repair mechanisms that result in reduced levels of steady-state oxidative-DNA damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt
KW - Polycyclic aromatic compounds
KW - DNA
KW - Genes
KW - Pyrene (Chemical)
KW - Leucocytes
KW - Construction workers
KW - 1-OH Pyrene
KW - 8-Epi-prostaglandin2α
KW - 8-Epi-prostaglandin2α
KW - 8-Hydroxydeoxyguanosine
KW - Asphalt fume
KW - Coal-tar pitch
KW - DNA strand breaks
KW - Oxidative DNA damage
N1 - Accession Number: 16129476; Toraason, Mark 1; Hayden, Charles 1; Marlow, Dave 1; Rinehart, Richard 2; Mathias, Patty 1; Werren, Dwight 1; DeBord, D. Gayle 1; Reid, Thomas M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; 2: Harvard School of Public Health, Boston, MA, USA.; Issue Info: Aug2001, Vol. 74 Issue 6, p396; Thesaurus Term: Asphalt; Thesaurus Term: Polycyclic aromatic compounds; Subject Term: DNA; Subject Term: Genes; Subject Term: Pyrene (Chemical); Subject Term: Leucocytes; Subject Term: Construction workers; Author-Supplied Keyword: 1-OH Pyrene; Author-Supplied Keyword: 8-Epi-prostaglandin2α; Author-Supplied Keyword: 8-Epi-prostaglandin2α; Author-Supplied Keyword: 8-Hydroxydeoxyguanosine; Author-Supplied Keyword: Asphalt fume; Author-Supplied Keyword: Coal-tar pitch; Author-Supplied Keyword: DNA strand breaks; Author-Supplied Keyword: Oxidative DNA damage; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fisher, William H.
AU - Barreira, Paul J.
AU - Lincoln, Alisa K.
AU - Simon, Lorna J.
AU - White, Andrew W.
AU - Roy-Bujnowski, Kristen
AU - Sudders, Marylou
AU - Fisher, W H
AU - Barreira, P J
AU - Lincoln, A K
AU - Simon, L J
AU - White, A W
AU - Roy-Bujnowski, K
AU - Sudders, M
T1 - Insurance status and length of stay for involuntarily hospitalized patients.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 2001/08//
VL - 28
IS - 3
M3 - journal article
SP - 334
EP - 346
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - General and private psychiatric hospitals are becoming increasingly common as sites for involuntary hospitalization. Unlike the public facilities that these settings are supplanting, these hospitals must pay strict attention to issues associated with reimbursement, insurance status, and managed care. This article examines the effects of insurance status on length of stay for involuntarily hospitalized patients in general and private hospitals in Massachusetts. Using a two-stage sampling procedure, data on episodes of involuntary hospitalization were gathered and assessed using multiple regression. The primary effect was found between patients with Medicare, who had the longest stays, and individuals who were uninsured, who had the shortest. The data raise concerns that warrant closer scrutiny on the part of administrators and clinicians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Behavioral Health Services & Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LENGTH of stay in hospitals
KW - HEALTH insurance
KW - MENTAL health services
KW - MASSACHUSETTS
KW - UNITED States
N1 - Accession Number: 4981703; Fisher, William H.; Barreira, Paul J.; Lincoln, Alisa K.; Simon, Lorna J.; White, Andrew W.; Roy-Bujnowski, Kristen; Sudders, Marylou; Fisher, W H 1; Barreira, P J; Lincoln, A K; Simon, L J; White, A W; Roy-Bujnowski, K; Sudders, M; Source Information: Aug2001, Vol. 28 Issue 3, p334; Subject: LENGTH of stay in hospitals; Subject: HEALTH insurance; Subject: MENTAL health services; Geographic Terms: MASSACHUSETTS; UNITED States; Number of Pages: 13p; Illustrations: 1 Graph; Document Type: journal article; Full Text Word Count: 6813
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=4981703&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2001-18501-005
AN - 2001-18501-005
AU - Roberts, Charles
AU - Macneill Horton, Arthur Jr.
T1 - Using the Trail Making Test to screen for cognitive impairment in a drug abuse treatment sample.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/08//
VL - 109
IS - 3-4
SP - 273
EP - 280
CY - US
PB - Gordon & Breach Science Publishers, Inc.
SN - 0020-7454
SN - 1563-5279
N1 - Accession Number: 2001-18501-005. PMID: 11699333 Partial author list: First Author & Affiliation: Roberts, Charles; Ctr for Substance Abuse Treatment, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Other Publishers: Informa Healthcare; Taylor & Francis. Release Date: 20010919. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Drug Abuse; Neuropsychological Assessment; Screening; Treatment. Minor Descriptor: Cognitive Impairment. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2001.
AB - The Trail Making Test (TMT) is a brief paper and pencil neuropsychological test often used for screening for cognitive impairment. The value of the TMT is examined in a sample of 5,619 males and 2,902 females (average age 32.6 yrs) was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study, a naturalistic, prospective cohort study that collected data from 1991–1993 in 96 programs in 11 cities in the US. Data were analyzed to determine the effects of specific drugs of abuse on parts A and B of the TMT in this large sample of patients in drug abuse treatment programs. Most Ss, regardless of type of drug abused, on TMT parts A and B appeared to fall within normal limits relative to commonly accepted cutoff scores. These results suggest that the TMT parts A and B would have great value as screening measures for cognitive impairment in a drug abuse treatment population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognitive screening
KW - Trail Making Test
KW - drug abuse
KW - drug abuse treatment
KW - cognitive impairment
KW - 2001
KW - Cognitive Ability
KW - Drug Abuse
KW - Neuropsychological Assessment
KW - Screening
KW - Treatment
KW - Cognitive Impairment
KW - 2001
DO - 10.3109/00207450108986538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-18501-005&site=ehost-live&scope=site
UR - croberts@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-18501-006
AN - 2001-18501-006
AU - Macneill Horton, Arthur Jr.
AU - Roberts, Charles
T1 - Demographic effects on the Trail Making Test in alcohol abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/08//
VL - 109
IS - 3-4
SP - 281
EP - 287
CY - US
PB - Gordon & Breach Science Publishers, Inc.
SN - 0020-7454
SN - 1563-5279
N1 - Accession Number: 2001-18501-006. Partial author list: First Author & Affiliation: Macneill Horton, Arthur Jr.; Ctr for Substance Abuse Treatment, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Other Publishers: Informa Healthcare; Taylor & Francis. Release Date: 20010919. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Demographic Characteristics; Neuropsychological Assessment; Treatment. Minor Descriptor: Age Differences; Educational Attainment Level; Human Sex Differences; Racial and Ethnic Differences. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2001.
AB - Demographic effects on the Trail Making Test (TMT), a test often used for screening for cognitive impairment, are examined in a sample of alcohol abusers (aged 18–44+ yrs) in drug abuse treatment programs. A sample was drawn from electronic files of data from the Drug Abuse Treatment outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991–1993 in 96 programs in 11 cities in the US. The number of alcohol abuser's scores available for analysis was 1000. Data were analyzed to determine the effects of gender, ethnicity, age and education variables on the 2 parts of the TMT in this large treatment sample of alcohol abusers. The variables of age, ethnicity and education were statistically significant for both parts A and B of the TMT. R-Square values for overall models were quite weak suggesting that demographic effects on the TMT, while clearly present, account for relatively little overall variance in terms of alcohol abuser's TMT performance. These results are consistent with earlier research using a more heterogenous drug abuse treatment sample. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol
KW - substance abuse treatment
KW - Trail Making Test
KW - demographic effects
KW - sex
KW - age
KW - ethnicity
KW - education
KW - 2001
KW - Alcohol Abuse
KW - Demographic Characteristics
KW - Neuropsychological Assessment
KW - Treatment
KW - Age Differences
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Racial and Ethnic Differences
KW - 2001
DO - 10.3109/00207450108986539
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-18501-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 107072304
T1 - Failure to report ethical approval in child health research: review of published papers.
AU - Bauchner H
AU - Sharfstein J
Y1 - 2001/08/11/
N1 - Accession Number: 107072304. Language: English. Entry Date: 20011130. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Institutional National Research Service Award and Faculty Development Program Grant to Department of Pediatrics, Boston University School of Medicine. NLM UID: 101090866.
KW - Research Ethics
KW - Consent (Research)
KW - Research Subjects -- In Infancy and Childhood
KW - Literature Review
KW - Serial Publications
KW - Publishing
KW - Child Welfare
KW - Child
KW - Child, Preschool
KW - Institutional Review
KW - Funding Source
KW - Human
SP - 318
EP - 319
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
JA - BMJ
VL - 323
IS - 7308
PB - BMJ Publishing Group
SN - 0959-8146
AD - Agency for Healthcare Research and Quality, Rockville, MD 20852
U2 - PMID: 11498489.
DO - 10.1136/bmj.323.7308.318
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107072304&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106981068
T1 - Liver enzyme monitoring in patients treated with troglitazone.
AU - Graham DJ
AU - Drinkard CR
AU - Shatin D
AU - Tsong Y
AU - Burgess MJ
AU - Graham, D J
AU - Drinkard, C R
AU - Shatin, D
AU - Tsong, Y
AU - Burgess, M J
Y1 - 2001/08/15/
N1 - Accession Number: 106981068. Language: English. Entry Date: 20021122. Revision Date: 20161112. Publication Type: journal article; CEU; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: FD-U-000149/FD/FDA HHS/United States. NLM UID: 7501160.
KW - Drug Monitoring
KW - Troglitazone -- Adverse Effects
KW - Liver Failure -- Chemically Induced
KW - Liver Failure -- Prevention and Control
KW - United States Food and Drug Administration
KW - Liver Function Tests -- Utilization
KW - Risk Management
KW - Drug Labeling
KW - Liver Failure -- Risk Factors
KW - Data Analysis, Statistical
KW - Aminotransferases -- Blood
KW - Education, Continuing (Credit)
KW - Funding Source
KW - Human
SP - 831
EP - 864
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 286
IS - 7
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Soon after initial marketing in March 1997, troglitazone, the first thiazolidinedione antidiabetic agent, was found to cause life-threatening acute liver failure. The drug was removed from the market in March 2000.Objective: To evaluate the effect of US Food and Drug Administration (FDA) risk management efforts, including repeated labeling changes and "Dear Healthcare Professional" letters, on periodic liver enzyme monitoring of patients taking troglitazone.Design, Setting, and Participants: Claims data from a large, multistate managed care organization were used to establish 4 cohorts of patients (N = 7603) with at least 90 days of health plan enrollment before first troglitazone prescription during 4 consecutive periods spanning April 1997 to September 1999 and representing 4 progressively stringent liver monitoring recommendations.Main Outcome Measures: Percentage of eligible troglitazone users in each cohort with baseline, monthly (for up to 6 months of continuous use), and complete (baseline and monthly) enzyme monitoring, based on computerized records of laboratory claims.Results: Baseline testing increased from 15% before any FDA monitoring recommendations (cohort 1) to 44.6% following 4 separate FDA interventions (cohort 4; P<.001). In cohort 4, 33.4% of users had follow-up testing after 1 month of therapy, falling to 13% after 5 months of continuous use. In all cohorts, less than 5% received all recommended liver enzyme tests by the third month of continuous use.Conclusions: The FDA risk management efforts did not achieve meaningful or sustained improvement in liver enzyme testing. Evaluation of the impact of regulatory actions is needed before such actions can be regarded as effective or sufficient.
SN - 0098-7484
AD - Office of Postmarketing Drug Risk Assessment, US Food and Drug Administration, 5600 Fishers Ln, HFD-400, Room 15B-32, Rockville, MD 20857, USA
AD - Office of Postmarketing Drug Risk Assessment, US Food and Drug Administration, 5600 Fishers Ln, HFD-400, Room 15B-32, Rockville, MD 20857; grahamd@cder.fda.gov
U2 - PMID: 11497537.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106981068&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106923846
T1 - The effect of wearing a back belt on spine kinematics during asymmetric lifting of large and small boxes.
AU - Giorcelli RJ
AU - Hughes RE
AU - Wassell JT
AU - Hsiao H
Y1 - 2001/08/15/2001 Aug 15
N1 - Accession Number: 106923846. Language: English. Entry Date: 20020517. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7610646.
KW - Orthoses
KW - Spine
KW - Biomechanics
KW - Lifting
KW - Kinematics
KW - Crossover Design
KW - Motion Analysis Systems
KW - Male
KW - Female
KW - Flexion
KW - Hip
KW - Knee
KW - Torso
KW - Rotation
KW - Extension
KW - Adolescence
KW - Adult
KW - Descriptive Statistics
KW - Body Weights and Measures
KW - Electrocardiography
KW - Random Assignment
KW - Wilcoxon Signed Rank Test
KW - Confidence Intervals
KW - Human
SP - 1794
EP - 1798
JO - Spine (03622436)
JF - Spine (03622436)
JA - SPINE
VL - 26
IS - 16
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - STUDY DESIGN: A crossover design was used to evaluate kinematic measurements collected with an infrared-based motion measurement system. OBJECTIVES: To evaluate belt effects on spine kinematics during asymmetric lifting of large and small boxes and to test for carryover effects between trials from belts. SUMMARY OF BACKGROUND DATA: Conflicting evidence in the literature exists regarding whether belts are beneficial or detrimental to manual material handlers. Studies have not examined belt effects when lifting different sized boxes, nor carryover effects from belts. METHODS: Twenty-eight subjects with manual-handling experience (17 male and 11 female) were randomly assigned to lift either a large or small box (weighing 9.4 kg), from a sagittally symmetric origin at pallet height to a 79 cm height, 60 degrees to the right. Spine flexion, lateral bending and twisting, hip and knee flexion, and angular velocity measurements of the torso with respect to the pelvis were collected for each of three lifting periods, 50 lifts each at 3 lifts per minute, with 18-minute breaks between periods. RESULTS: Belts significantly reduced maximum spine flexion, spine flexion and extension angular velocities, and torso left lateral bending angular velocity, and increased hip and knee flexion, regardless of box size. When lifting large boxes, belts significantly reduced torso right lateral bending and torso left twisting. No significant differential carryover effects were detected from belts. CONCLUSIONS: Subjects with belts lifted more slowly and used more of a squat-lift technique, regardless of box size. Belts reduced more torso motions while lifting large boxes.
SN - 0362-2436
AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 11493853.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106923846&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106603656
T1 - Looking for jobs in all the right places.
AU - Belsito LJ
Y1 - 2001/08/27/2001 Aug 27
N1 - Accession Number: 106603656. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article; anecdote; pictorial. Journal Subset: Nursing; USA. NLM UID: 9892044.
KW - Careers in Nursing
SP - 4p
EP - 4p
JO - Nursing Spectrum -- New York & New Jersey Edition
JF - Nursing Spectrum -- New York & New Jersey Edition
JA - NURS SPECTRUM (NY NJ)
VL - 13A
IS - 17
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1081-3101
AD - United States Public Health Service
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106603656&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106925698
T1 - The role of Stachybotrys mycotoxins in building-related illness.
AU - Page EH
AU - Trout DB
Y1 - 2001/09//2001 Sep-Oct
N1 - Accession Number: 106925698. Language: English. Entry Date: 20020524. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100939625.
KW - Fungi -- Poisoning
KW - Sick Building Syndrome
KW - Literature Review
KW - Medline
KW - Mycoses
KW - National Institute for Occupational Safety and Health
KW - Reference Databases
SP - 644
EP - 648
JO - AIHAJ
JF - AIHAJ
JA - AIHAJ
VL - 62
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Recently there has been increased attention among both the public and health professionals regarding the potential role of mycotoxins, primarily from fungi of the genus Stachybotrys, as etiologic agents related to illness among persons exposed in the indoor (nonindustrial) environment. Recommendations for the remediation of buildings are being made based in part on reported health effects believed to be due to mycotoxins. A search of NIOSHTIC (a literature database maintained by the National Institute for Occupational Safety and Health) and MEDLINE (from 1965 to present) for literature related to fungi, mycotoxins, and the indoor environment was conducted. References from relevant articles also were reviewed. This strategy yielded a total of 13 articles. Important issues concerning exposure assessment and case definitions are inadequately addressed in the literature reviewed, making it difficult to implicate mycotoxins as a cause of building-related illness. The literature review indicates that currently there is inadequate evidence supporting a causal relationship between symptoms or illness among building occupants and exposure to mycotoxins. Research involving the identification and isolation of specific fungal toxins in the environment and in humans is needed before a more definitive link between health outcomes and mycotoxins can be made.
SN - 1529-8663
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-10, Cincinnati, OH 45226-1998; edp7@cdc.gov
U2 - PMID: 11669391.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106925698&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106901170
T1 - The effects of use and simulated reuse on percutaneous transluminal coronary angioplasty balloons and catheters.
AU - Brown SA
AU - Merritt K
AU - Woods TO
AU - Hitchins VM
AU - Brown, S A
AU - Merritt, K
AU - Woods, T O
AU - Hitchins, V M
Y1 - 2001/09//2001 Sep-Oct
N1 - Accession Number: 106901170. Language: English. Entry Date: 20020215. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Angioplasty, Transluminal, Percutaneous Coronary -- Equipment and Supplies
KW - Equipment Reuse
KW - Disposable Equipment
KW - Equipment Reliability
KW - In Vitro Studies
KW - T-Tests
KW - Paired T-Tests
KW - Human
SP - 312
EP - 322
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 35
IS - 5
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - A series of studies was undertaken to determine the effects of single patient use and simulated reuse on percutaneous transluminal coronary angioplasty (PTCA) balloon catheters. Catheters were retrieved from Walter Reed Army Medical Center and were low-level disinfected and cleaned at the US Food and Drug Administration. They were then tested for balloon compliance, and the results were compared against the manufacturer's specifications. Selected groups of catheters were subjected to EO-resterilization and a simulated reuse protocol. The results demonstrated that the effects of use and EO-resterilization is model specific. Furthermore, some balloons demonstrated a time-dependent behavior while others recovered from the effects of simulated reuse by compliance testing at high pressure. Testing for the slipperiness of the catheters after repeated EO-resterilization also demonstrated that changes were model specific.
SN - 0899-8205
AD - Division of Mechanics and Materials Science, HFZ-150, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, Rockville, MD 20850, USA
AD - Division of Mechanics and Materials Science, HFZ-150, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, Rockville, MD 20850
U2 - PMID: 11668948.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106901170&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692564
T1 - How the US Food and Drug Administration defines and detects adverse drug events.
AU - Trontell AE
Y1 - 2001/09//2001 Sep
N1 - Accession Number: 106692564. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: National Institute of Child Health and Human Development, the US Food and Drug Administration, the Agency for Healthcare Research and Quality, and the United States Pharmacopeia. NLM UID: 0372621.
KW - Adverse Drug Event -- Evaluation -- In Infancy and Childhood
KW - Reports -- Standards
KW - United States Food and Drug Administration -- Standards
KW - Adolescence
KW - Child
KW - Descriptive Statistics
KW - Drug Labeling
KW - Funding Source
KW - Human
SP - 641
EP - 649
JO - Current Therapeutic Research
JF - Current Therapeutic Research
JA - CURR THER RES
VL - 62
IS - 9
CY - New York, New York
PB - Elsevier Science
AB - Background: Examination of pediatric adverse drug events (ADEs) requires an understanding of the US Food and Drug Administration's (FDA's) regulatory definitions of ADEs and methods for their assessment.Objective: The aim of this paper was to characterize the tools used by the FDA to define ADEs.Methods: FDA regulations and ADE reporting databases and resources were examined, including the Adverse Event Reporting System (AERS), drug-use profile, population databases, and active surveillance systems.Results: The US Code of Federal Regulations defines ADEs and degrees of seriousness of ADEs for regulatory reporting purposes. Drug manufacturers must report certain ADEs to the FDA, whereas health care professionals and consumers may report such events voluntarily using the MedWatch program. All reported ADEs constitute the FDA's AERS, which is used along with other postmarketing surveillance components to determine drug safety signals. AERS detects rare ADEs well and inexpensively, but underreporting and the variable quality of reports can limit its usefulness. AERS is best used in conjunction with other data resources, such as active surveillance systems, information on the volume and patterns of medication use, disease-specific background incidence rates, and population databases that can link outcomes with drug exposures.Conclusions: The FDA uses a network of data resources to supplement detection of ADEs via AERS. These data resources can be used to amplify, validate, and quantify ADE signals and then compare them to their expected background occurrence in the population. Use of additional databases and perspectives will improve the ability to detect ADEs in all settings, including the pediatric population, and to monitor risk management efforts to curtail the occurrence of known ADEs.
SN - 0011-393X
AD - Office of Post-Marketing Drug Risk Assessment, Division of Drug Risk Evaluation 1, HFD-430, Parklawn Room 15B-08, US Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; trontella@cder.fda.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106692564&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692570
T1 - Some US Food and Drug Administration perspectives on data mining for pediatric safety assessment.
AU - O'Neill RT
AU - Szarfman A
Y1 - 2001/09//2001 Sep
N1 - Accession Number: 106692570. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372621.
KW - Adverse Drug Event -- Epidemiology -- In Infancy and Childhood
KW - Data Mining
KW - United States Food and Drug Administration
KW - Adolescence
KW - Child
KW - Child Safety
KW - Child, Preschool
KW - Infant
KW - Infant, Newborn
KW - Prescriptions, Drug -- Trends
SP - 650
EP - 663
JO - Current Therapeutic Research
JF - Current Therapeutic Research
JA - CURR THER RES
VL - 62
IS - 9
CY - New York, New York
PB - Elsevier Science
AB - Background: The US Food and Drug Administration's (FDA's) large spontaneous reporting database contains>110,000 voluntary reports of adverse drug events (ADEs) observed during postmarketing pediatric practice and submitted to the FDA by manufacturers, health care providers, or consumers. These reports may provide evidence about known or unknown harm associated with single or combination drug treatments in pediatric patients. We recently implemented new Bayesian data mining tools to evaluate>2 million reports stored in this database to help systematically identify safety signals that appear with unexpectedly high frequency.Objective: The purpose of this paper was to describe the current status of the application of Bayesian data mining tools to screen pediatric reports of ADEs submitted spontaneously to the FDA.Methods: We applied DuMouchel's empirical Bayesian data mining algorithms to the FDA's spontaneous reporting database. These methods circumvent the lack of exposure denominators in passive surveillance data. The first method implemented, the Gamma-Poisson Shrinkage model (GPS) computer program, detects higher-than-expected associations between drugs and adverse events. The method currently being used, the updated GPS program implemented in a software program called MGPS, adjusts for the multiplicity of drugs and events per record in the data reported after October 1997 and generalizes to multiple combinations of drugs and events (eg, triples, quadruples) that occur together in reports with unexpectedly high frequency. MGPS also identifies how much these unusually frequent itemsets can be explained by pairwise associations. For this article, we used the MGPS program to analyze pairwise, higher-than-expected associations between drugs and adverse events in pediatric reports.Results: We illustrate the potential of the data mining techniques to improve the early detection and analysis of new adverse events involving unusually frequent drug-event pairs in pediatric reports and to verify the significance of known ADEs.Conclusions: New data mining techniques help skilled safety evaluators and epidemiologists at the FDA analyze reports of pediatric ADEs submitted to the FDA spontaneously. These tools are not intended to replace current pharmacovigilance techniques but to enhance them. In the near future, these techniques should facilitate our study of potential drug interactions, a serious problem for pediatric patients requiring complicated medication regimens.
SN - 0011-393X
AD - Director, Office of Biostatistics, Center for Drug Evaluation and Research, US Food and Drug Administration, 9201 Corporate Boulevard, HFD-104, Rockville, MD 20850; oneill@cder.fda.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106692570&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ding, Linna
AU - Shevach, Ethan M.
T1 - Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen.
JO - Immunology
JF - Immunology
Y1 - 2001/09//
VL - 104
IS - 1
M3 - Article
SP - 28
EP - 36
SN - 00192805
AB - SummaryThymic shared antigen-1 (TSA-1) is a member of the Ly-6 family of glycosyl-phosphatidylinositol (GPI)-linked proteins. While it has been proposed that TSA-1 may play a role in thymic development, a physiological ligand for this antigen has not been identified. Here we report that a monoclonal antibody (mAb) to TSA-1, generated by immunizing a hamster with CD40 ligand (CD40L)-activated B cells, interferes with the function of FcγRIIB on splenic B cells and the B-cell lymphoma cell line, M12, by binding to TSA on the same cells. The interaction of anti-TSA with FcγRIIB resulted in an inhibition of the ability of the FcγRIIB to cross-link and/or aggregate soluble anti-CD3 or soluble anti-Cβ T-cell receptor (TCR), leading to an inhibition of induction of expression of CD25 and CD69, interleukin (IL)-2 production and proliferation of naive T cells. Cross-blocking studies with mAbs strongly suggested that a physical association exists between TSA-1 and the FcγRIIB on the surface of activated B cells and favour the view that a functional intermolecular association exists between these two distinct membrane antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - FC receptors
KW - IMMUNE complexes
KW - B cells
N1 - Accession Number: 5212914; Ding, Linna 1; Shevach, Ethan M. 2; Source Information: Sep2001, Vol. 104 Issue 1, p28; Subject: MONOCLONAL antibodies; Subject: FC receptors; Subject: IMMUNE complexes; Subject: B cells; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2567.2001.01275.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5212914&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106934864
T1 - Designing employer health benefits for a heterogeneous workforce: risk adjustment and its alternatives.
AU - Encinosa WE
AU - Selden TM
Y1 - 2001///Fall2001
N1 - Accession Number: 106934864. Language: English. Entry Date: 20020628. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Salaries and Fringe Benefits -- Economics
KW - Health Services Purchasing
KW - Managed Care Programs -- Economics
KW - Risk Assessment -- Utilization
KW - Consumer Participation -- Economics
KW - United States
SP - 270
EP - 279
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 38
IS - 3
PB - Sage Publications Inc.
AB - Many health economists recommend that employers provide employees with a risk-adjusted choice among competing health insurance plans. However, formal risk adjustment is rarely if ever used by employers. This paper examines a range of health benefit design options available to employers, focusing attention not only on risk adjustment but also on its alternatives. We argue that while formal risk adjustment is rare, employers commonly use strategies that accomplish some of the same objectives at less cost.
SN - 0046-9580
AD - Economist, Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, 2101 East Jefferson St., Rockville, MD 20852
U2 - PMID: 11761354.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106934864&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106934873
T1 - Location, race, and hospital care for AIDS patients: an analysis of 10 states.
AU - Hellinger FJ
AU - Fleishman JA
Y1 - 2001///Fall2001
N1 - Accession Number: 106934873. Language: English. Entry Date: 20020628. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Acquired Immunodeficiency Syndrome -- Epidemiology -- United States
KW - Hospitalization
KW - Hospital Mortality
KW - Hospitals, Community -- Utilization
KW - United States
KW - Health Resource Allocation
KW - Utilization Review
KW - Length of Stay
KW - Ethnic Groups
KW - Comparative Studies
KW - Adult
KW - Male
KW - Female
KW - Whites
KW - Blacks
KW - Hispanics
KW - Comorbidity
KW - AIDS-Related Opportunistic Infections -- Epidemiology
KW - Logistic Regression
KW - Record Review
KW - Retrospective Design
KW - Descriptive Statistics
KW - Odds Ratio
KW - Confidence Intervals
KW - Severity of Illness
KW - Human
SP - 319
EP - 330
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 38
IS - 3
PB - Sage Publications Inc.
AB - This study is the first statewide comparison of hospital utilization and inpatient mortality rates for people with acquired immune deficiency syndrome (AIDS). Data from 120,772 hospital discharge abstracts for all AIDS-related admissions in 10 states (California, Colorado, Florida, Iowa, Kansas, Maryland, New Jersey, New York, Pennsylvania, and South Carolina) in 1996 were combined with data on the number and the racial and ethnic characteristics of all people living with AIDS (PLWAs) in each state. These data were used to derive population-based estimates of the use of hospital services per PLWA and of inpatient mortality rates in each state. Multivariate analyses examined sources of variation in inpatient length of stay and inpatient mortality. The primary finding of this study is that hospital utilization rates and inpatient mortality rates for people with AIDS vary substantially across states and among racial and ethnic groups within states even after adjusting for severity of illness. Blacks and Hispanics had longer hospital stays and were more likely to die in the hospital than whites. State-level policies, such as home and community-based waiver programs and enhanced HIV reimbursement rates, significantly affected hospital use.
SN - 0046-9580
AD - Economist, Agency for Healthcare Research and Quality (AHRQ), 2101 East Jefferson St., Suite 605, Rockville, MD 20852
U2 - PMID: 11761360.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106934873&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Blumberg, Linda J.
AU - Nichols, Len M.
AU - Banthin, Jessica S.
AD - Urban Institute
AD - Center for Studying Health System Change
AD - Agency for Healthcare Research and Quality
T1 - Worker Decisions to Purchase Health Insurance
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2001/09//September-December 2001
VL - 1
IS - 3-4
SP - 305
EP - 325
SN - 13896563
N1 - Accession Number: 0808242; Keywords: Elasticities; Expenditure; Health Insurance; Health; Households; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200512
N2 - Studying worker health insurance choices is usually limited by the absence of price data for workers who decline their employer's offer. This paper uses a new Medical Expenditure Panel Survey file which links household and employer survey respondents, supplying data for both employer insurance takers and decliners. We test for whether out-of-pocket or total premium better explains worker behavior, estimate price elasticities with observed prices and with imputed prices, and test for worker sorting among jobs with and without health insurance. We find that out-of-pocket price dominates, that there is some upward bias from estimating elasticities with imputed premiums rather than observed premiums, and that workers do sort among jobs but this does not affect elasticity estimates appreciably. Like earlier studies with less representative worker samples, we find worker price elasticity of demand to be quite low. This suggests that any premium subsidies must be large to elicit much change in worker take-up behavior.
KW - Consumer Economics: Empirical Analysis D12
KW - Household Saving; Personal Finance D14
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
L3 - http://link.springer.com/journal/volumesAndIssues/10754
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0808242&site=ehost-live&scope=site
UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Nakano, M.
AU - Kodama, Y.
AU - Ohtaki, K.
AU - Itoh, M.
AU - Delongchamp, R.
AU - Awa, A. A.
AU - Nakamura, N.
T1 - Detection of stable chromosome aberrations by FISH in A-bomb survivors: comparison with previous solid Giemsa staining data on the same 230 individuals.
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
Y1 - 2001/09//
VL - 77
IS - 9
M3 - Article
SP - 971
EP - 977
PB - Taylor & Francis Ltd
SN - 09553002
AB - Purpose: To evaluate the relative abilities of the solid Giemsa staining (conventional) and fluorescence in situ hybridization (FISH) methods in the detection of stable chromosome aberrations in the peripheral blood lymphocytes of A-bomb survivors. Materials and methods: Lymphocytes from a total of 230 A-bomb survivors for whom prior chromosome aberration data had been obtained by the conventional method were recently examined afresh using FISH in which chromosomes 1, 2 and 4 were painted with composite probes. Results: It was found that the early use of the solid Giemsa staining method had allowed the detection of translocations with a mean frequency of 73% of the value for the genome-equivalent translocation frequency (F[sub G] ) that was now obtained using FISH. The disparity may at least in part be due to the reciprocal exchange of seemingly identical amount of chromosome material; such exchanges can escape detection by the conventional method but can be readily identified using FISH. Conclusion: It has previously been established that the conventional method can detect about 20% of radiation-induced translocations as abnormal monocentric chromosomes. Present results indicate that an additional 50% can be detected if proper karyotyping is conducted and the remaining 30% are not likely to be detected unless FISH or banding methods are used. Thus, solid Giemsa staining accompanied by karyotyping may not be quite as unsuitable as is generally assumed for retrospective biodosimetry analyses, which deal mainly with stable aberrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Radiation Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAINS & staining (Microscopy)
KW - CHROMOSOMES
KW - LYMPHOCYTES
KW - RADIATION
N1 - Accession Number: 5254363; Nakano, M. 1; Kodama, Y. 1; Ohtaki, K. 1; Itoh, M. 1; Delongchamp, R. 2; Awa, A. A. 1; Nakamura, N. 1; Source Information: Sep2001, Vol. 77 Issue 9, p971; Subject: STAINS & staining (Microscopy); Subject: CHROMOSOMES; Subject: LYMPHOCYTES; Subject: RADIATION; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/09553000110050065
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5254363&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Turner, Barbara J.
AU - Fleishman, John A.
AU - Wenger, Neil
AU - London, Andrew S.
AU - Burnam, M. Audrey
AU - Shapiro, Martin F.
AU - Bing, Eric G.
AU - Stein, Michael D.
AU - Longshore, Douglas
AU - Bozzette, Samuel A.
AU - Turner, B J
AU - Fleishman, J A
AU - Wenger, N
AU - London, A S
AU - Burnam, M A
AU - Shapiro, M F
AU - Bing, E G
AU - Stein, M D
AU - Longshore, D
AU - Bozzette, S A
T1 - Effects of drug abuse and mental disorders on use and type of antiretroviral therapy in HIV-infected persons.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2001/09//
VL - 16
IS - 9
M3 - journal article
SP - 625
EP - 633
SN - 08848734
AB - Objective: To distinguish the effects of drug abuse, mental disorders, and problem drinking on antiretroviral therapy (ART) and highly active ART (HAART) use.Design: Prospective population-based probability sample of 2,267 (representing 213,308) HIV-infected persons in care in the United States in early 1996.Measurements: Self-reported ART from first (January 1997-July 1997) to second (August 1997-January 1998) follow-up interviews. Drug abuse/dependence, severity of abuse, alcohol use, and probable mental disorders assessed in the first follow-up interview. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) estimated from weighted models for 1) receipt of any ART, and 2) receipt of HAART among those on ART.Results: Of our study population, ART was reported by 90% and HAART by 61%. Over one third had a probable mental disorder and nearly half had abused any drugs, but drug dependence (9%) or severe abuse (10%) was infrequent. Any ART was less likely for persons with dysthymia (AOR, 0.74; CI, 0.58 to 0.95) but only before adjustment for drug abuse. After full adjustment with mental health and drug abuse variables, any ART was less likely for drug dependence (AOR, 0.58; CI, 0.34 to 0.97), severe drug abuse (AOR, 0.52; CI, 0.32 to 0.87), and HIV risk from injection drug use (AOR, 0.55; CI, 0.39 to 0.79). Among drug users on ART, only mental health treatment was associated with HAART (AOR, 1.57; CI, 1.11 to 2.08).Conclusions: Drug abuse-related factors were greater barriers to ART use in this national sample than mental disorders but once on ART, these factors were unrelated to type of therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - MENTAL illness
KW - HIV-positive persons -- Medical care
KW - anti-HIV agents
KW - HIV infections
KW - mental disorders
KW - substance abuse, intravenous drug abuse
KW - substance-related disorders
N1 - Accession Number: 5528152; Turner, Barbara J. 1; Fleishman, John A. 1; Wenger, Neil 1; London, Andrew S. 1; Burnam, M. Audrey 1; Shapiro, Martin F. 1; Bing, Eric G. 1; Stein, Michael D. 1; Longshore, Douglas 1; Bozzette, Samuel A. 1; Turner, B J 2; Fleishman, J A; Wenger, N; London, A S; Burnam, M A; Shapiro, M F; Bing, E G; Stein, M D; Longshore, D; Bozzette, S A; Source Information: Sep2001, Vol. 16 Issue 9, p625; Subject: DRUG abuse; Subject: MENTAL illness; Subject: HIV-positive persons -- Medical care; Author-Supplied Keyword: anti-HIV agents; Author-Supplied Keyword: HIV infections; Author-Supplied Keyword: mental disorders; Author-Supplied Keyword: substance abuse, intravenous drug abuse; Author-Supplied Keyword: substance-related disorders; Number of Pages: 9p; Document Type: journal article
L3 - 10.1046/j.1525-1497.2001.016009625.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5528152&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106790920
T1 - Does a healthy health care workplace produce higher-quality care?
AU - Eisenberg JM
AU - Bowman CC
AU - Foster NE
Y1 - 2001/09//2001 Sep
N1 - Accession Number: 106790920. Language: English. Entry Date: 20030103. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9315239.
KW - Health Facility Environment
KW - Occupational Health
KW - Quality of Health Care
KW - Government Agencies
KW - Congresses and Conferences
KW - Interior Design and Furnishings
KW - Organizational Culture
KW - Personnel Staffing and Scheduling
KW - Personnel, Health Facility
KW - Job Satisfaction
KW - Professional Practice, Evidence-Based
KW - Health Facility Administration
SP - 444
EP - 457
JO - Joint Commission Journal on Quality Improvement
JF - Joint Commission Journal on Quality Improvement
JA - JOINT COMM J QUAL IMPROV
VL - 27
IS - 9
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1070-3241
AD - Director, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 2101 E. Jefferson St, Suite 600, Rockville, MD 20852; JEisenberg@ahrq.gov
U2 - PMID: 11556254.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106790920&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106790905
T1 - The forgotten component of the quality triad: can we still learn something from 'structure'?
AU - Meyer GS
AU - Massagli MP
Y1 - 2001/09//2001 Sep
N1 - Accession Number: 106790905. Language: English. Entry Date: 20030103. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9315239.
KW - Health Care Delivery
KW - Organizational Structure
KW - Quality Assessment
KW - Health Facility Environment
KW - Organizational Culture
KW - Job Satisfaction
KW - Process Assessment (Health Care)
KW - Outcomes (Health Care)
KW - Research
SP - 484
EP - 493
JO - Joint Commission Journal on Quality Improvement
JF - Joint Commission Journal on Quality Improvement
JA - JOINT COMM J QUAL IMPROV
VL - 27
IS - 9
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1070-3241
AD - Director, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 6011 Executive Boulevard, Suite 200, Rockville, MD 20852; gmeyer@ahrq.gov
U2 - PMID: 11556257.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106790905&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shearer, Steven
AU - Toedt, Michael
T1 - Family Physicians' Observations of Their Practice, Well Being, and Health Care in the United States.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2001/09//
VL - 50
IS - 9
M3 - Article
SP - 751
EP - 756
PB - Frontline Medical Communications
SN - 00943509
AB - OBJECTIVE: Our goal was to characterize how family physicians perceive recent changes in the health care system and how content they are with various factors. STUDY DESIGN: We performed a cross-sectional mailed survey. POPULATION: The survey was completed by a random sample of 361 family physicians practicing in the United States. OUTCOMES MEASURED: The survey evaluated attitudes about corporate managed care, health care reform, career satisfaction, compensation, personal life satisfaction, workload stress, personal well-being, and residency training. RESULTS: Relative to survey data gathered in 1996, fewer family physicians in our survey reported that they were satisfied with their careers (59% vs 82%); fewer were satisfied with their compensation (55% vs 65%); and fewer would again choose family practice as their specialty (66% vs 75%). Thirty-one percent worried that they were "burning out," as physicians, and 48% reported that they had experienced more stress-related symptoms in the past year. Only 7% agreed that corporate managed care is the best way to provide the health care America needs at a cost society can afford, but only 36% unequivocally endorsed the concept of a national health plan. Forty-two percent of the respondents reported that they had witnessed bad patient outcomes they perceived to be attributable to managed care business processes. CONCLUSIONS: The morale and career satisfaction of family physicians seems to have eroded in recent years, and discontent is common. As a group, family physicians are unhappy with the current health care system and quite unified about certain specific reforms, yet they are far from such consensus about more sweeping reform. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAMILY medicine
KW - PHYSICIANS (General practice)
KW - FAMILIES -- Health
KW - MEDICAL care
KW - JOB satisfaction
KW - ATTITUDE (Psychology)
KW - HEALTH care reform
KW - UNITED States
KW - attitudes about managed care [non-MESH]
KW - Career satisfaction [non-MESH]
KW - health care reform
KW - physician well being [non-MESH]
KW - physician well-being [non-MESH]
N1 - Accession Number: 5372399; Shearer, Steven 1; Email Address: steves@helix.org; Toedt, Michael 2; Source Information: Sep2001, Vol. 50 Issue 9, p751; Subject: FAMILY medicine; Subject: PHYSICIANS (General practice); Subject: FAMILIES -- Health; Subject: MEDICAL care; Subject: JOB satisfaction; Subject: ATTITUDE (Psychology); Subject: HEALTH care reform; Geographic Terms: UNITED States; Author-Supplied Keyword: attitudes about managed care [non-MESH]; Author-Supplied Keyword: Career satisfaction [non-MESH]; Author-Supplied Keyword: health care reform; Author-Supplied Keyword: physician well being [non-MESH]; Author-Supplied Keyword: physician well-being [non-MESH]; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5372399&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 104725638
T1 - HIV / AIDS in the age of palliative care. Foreword.
AU - O'Neill, J
AU - Higginson, I J
Y1 - 2001/09//
N1 - Accession Number: 104725638. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879.
KW - Acquired Immunodeficiency Syndrome -- Therapy
KW - Palliative Care -- Trends
KW - Great Britain
KW - United States
SP - 429
EP - 429
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
JA - J R SOC MED
VL - 94
IS - 9
PB - Sage Publications, Ltd.
SN - 0141-0768
AD - HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, USA.
U2 - PMID: 11535741.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104725638&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 104725644
T1 - Access to palliative care in the USA: why emphasize vulnerable populations?
AU - O'Neill, J
AU - Marconi, K
Y1 - 2001/09//
N1 - Accession Number: 104725644. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879.
KW - Ethnic Groups
KW - Health Services Accessibility -- Administration
KW - Minority Groups
KW - Palliative Care
KW - Primary Health Care -- Administration
KW - Health Services Accessibility -- Economics
KW - Health Services Accessibility -- Standards
KW - Medically Uninsured
KW - Palliative Care -- Standards
KW - Primary Health Care -- Standards
KW - Socioeconomic Factors
KW - United States
KW - United States Public Health Service -- Economics
SP - 452
EP - 457
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
JA - J R SOC MED
VL - 94
IS - 9
PB - Sage Publications, Ltd.
SN - 0141-0768
AD - HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 7-13, Rockville, MD 20857, USA.
U2 - PMID: 11535747.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104725644&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107055744
T1 - Device safety. Alarming monitor error...wasn't turned on
AU - Gallauresi B
Y1 - 2001/09//
N1 - Accession Number: 107055744. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Electrocardiography
KW - Monitoring, Physiologic -- Nursing
KW - Arrhythmia
SP - 31
EP - 31
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107055744&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106891886
T1 - CDRH summary report. FDA summarizes radiation therapy device problems.
AU - Kaczmarek R
Y1 - 2001///Fall2001
N1 - Accession Number: 106891886. Language: English. Entry Date: 20020118. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9206619.
KW - Brachytherapy -- Equipment and Supplies
KW - Equipment Failure
KW - United States Food and Drug Administration
SP - 158
EP - 158
JO - Radiation Therapist
JF - Radiation Therapist
JA - RADIAT THERAPIST
VL - 10
IS - 2
CY - Alburquerque, New Mexico
PB - American Society of Radiologic Technologists
SN - 1084-1911
AD - Food and Drug Administration Center for Devices and Radiological Health
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106891886&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106903071
T1 - Depressive disorder, dysthymia, and risk of stroke: thirteen-year follow-up from the Baltimore epidemiologic catchment area study.
AU - Larson SL
AU - Owens PL
AU - Ford D
AU - Eaton W
AU - Larson, S L
AU - Owens, P L
AU - Ford, D
AU - Eaton, W
Y1 - 2001/09//2001 Sep
N1 - Accession Number: 106903071. Language: English. Entry Date: 20020222. Revision Date: 20161126. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: MH 47447/MH/NIMH NIH HHS/United States. NLM UID: 0235266.
KW - Stroke -- Epidemiology
KW - Depression -- Epidemiology
KW - Dysthymic Disorder -- Epidemiology
KW - Stroke -- Risk Factors
KW - Prevalence
KW - Prospective Studies
KW - Logistic Regression
KW - Multiple Logistic Regression
KW - Confidence Intervals
KW - Relative Risk
KW - Adult
KW - Middle Age
KW - Aged
KW - Female
KW - Male
KW - Funding Source
KW - Human
SP - 1979
EP - 1983
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 32
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background and Purpose: This study examined depressive disorder as a risk factor for incident stroke in a prospective, population-based design.Methods: The Baltimore Epidemiologic Catchment Area Study is a prospective 13-year follow-up of a probability sample of household residents from Baltimore, Md. Depressive disorder was measured with the diagnostic interview schedule, and stroke was assessed by questions from the health interview survey or by documentation on a death certificate.Results: During the 13-year follow-up of 1703 individuals, 66 strokes were reported and 29 strokes were identified by death certificate search. Individuals with a history of depressive disorder were 2.6 times more likely to report stroke than those without this disorder after controlling for heart disease, hypertension, diabetes, and current and previous use of tobacco. Medications used in the treatment of depressive disorder at baseline did not alter this finding. A history of dysthymia demonstrated a similar relationship to stroke, although the estimate was not statistically significant.Conclusions: Depressive disorder is a risk factor for stroke that appears to be independent of traditional cardiovascular risk factors. Further research on mechanisms for the association and the impact of treatment for depressive disorder on subsequent stroke is needed.
SN - 0039-2499
AD - Johns Hopkins University Bloomberg School of Public Health, School of Medicine, Baltimore, Md, USA
AD - Agency for Healthcare Research and Quality (AHRQ), 2101 E Jefferson #500, Rockville, MD 20852. E-mail: sllarson@jhsph.edu
U2 - PMID: 11546884.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Walker, Lisa M.
AU - York, J. Lyndal
AU - Imam, Syed Z.
AU - Ali, Syed F.
AU - Muldrew, Kenneth L.
AU - Mayeux, Philip R.
T1 - Oxidative Stress and Reactive Nitrogen Species Generation during Renal Ischemia.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/09//
VL - 63
IS - 1
M3 - Article
SP - 143
EP - 148
PB - Oxford University Press / USA
SN - 10966080
AB - Previous evidence suggests that both oxygen radicals and nitric oxide (NO) are important mediators of injury during renal ischemia-reperfusion (I-R) injury. However, the generation of reactive nitrogen species (RNS) has not been evaluated in this model at early time points. The purpose of these studies was to examine the development of oxidant stress and the formation of RNS during I-R injury. Male Sprague-Dawley rats were anesthetized and subjected to 40 min of bilateral renal ischemia followed by 0, 3, or 6 h of reperfusion. Control animals received a sham operation. Plasma urea nitrogen and creatinine levels were monitored as markers of renal injury. Glutathione (GSH) oxidation and 4-hydroxynonenal (4-HNE)-protein adducts were used as markers of oxidant stress. 3-Nitrotyrosine (3-NT) was used as a biomarker of RNS formation. Significant increases in plasma creatinine concentrations and urea nitrogen levels were found following both 3 and 6 h of reperfusion. Increases in GSH oxidation, 4-HNE-protein adduct levels, and 3-NT levels were observed following 40 min of ischemia with no reperfusion. Since these results suggested RNS generation during the 40 min of ischemia, a time course of RNS generation following 0, 5, 10, 20, and 40 min of ischemia was evaluated. Significant increases in 3-NT generation was detected as early as 10 min of ischemia and rose to values nearly 10-fold higher than Control at 40 min of ischemia. No additional increase was observed following reperfusion. The data clearly demonstrate that oxidative stress and RNS generation occur in the kidney during ischemia. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitric oxide
KW - Active oxygen
KW - Rats as laboratory animals
KW - Ischemia
KW - Creatinine
KW - 3-nitrotyrosine
KW - 4-hydroxynonenal
KW - acute renal failure
KW - glutathione
KW - peroxynitrite
KW - renal ischemia
KW - superoxide
N1 - Accession Number: 44406199; Walker, Lisa M. 1; York, J. Lyndal 2; Imam, Syed Z. 3; Ali, Syed F. 1,2,3; Muldrew, Kenneth L. 1; Mayeux, Philip R. 1; Email Address: mayeuxphilipr@uams.edu; Affiliations: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; 2: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079; Issue Info: Sep2001, Vol. 63 Issue 1, p143; Thesaurus Term: Nitric oxide; Subject Term: Active oxygen; Subject Term: Rats as laboratory animals; Subject Term: Ischemia; Subject Term: Creatinine; Author-Supplied Keyword: 3-nitrotyrosine; Author-Supplied Keyword: 4-hydroxynonenal; Author-Supplied Keyword: acute renal failure; Author-Supplied Keyword: glutathione; Author-Supplied Keyword: peroxynitrite; Author-Supplied Keyword: renal ischemia; Author-Supplied Keyword: superoxide; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2001-09530-004
AN - 2001-09530-004
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Demographic effects on the Trail Making Test in marijuana abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/09//
VL - 110
IS - 3-4
SP - 173
EP - 180
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2001-09530-004. PMID: 11912867 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020130. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Marijuana; Neuropsychological Assessment. Minor Descriptor: Age Differences; Educational Attainment Level; Human Sex Differences; Racial and Ethnic Differences. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2001.
AB - Examined a sample of marijuana abusers' performance on a measure of cognitive impairment, the Trail Making Test (TMT), and assessed the relative influences of Ss' gender, ethnicity, age, and education level. Data on 259 marijuana abusers were drawn from the electronic files of the Drug Abuse Treatment Outcome Study (DATOS), a naturalistic, national, prospective cohort study of adults in drug abuse treatment programs. Age and education level were found to be statistically significant for both TMT parts A and B. Ethnicity was statistically significant for part B and showed a tendency toward significance for part A. Gender was not significant for either part. R-square values for overall models suggest that ethnicity, education level, and age have combined effects that account for only a low degree of variance in Ss' TMT performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marijuana abusers
KW - Trail Making Test
KW - gender
KW - ethnicity
KW - age
KW - education level
KW - drug abuse treatment
KW - 2001
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Marijuana
KW - Neuropsychological Assessment
KW - Age Differences
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Racial and Ethnic Differences
KW - 2001
DO - 10.3109/00207450108986544
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09530-004&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-09530-005
AN - 2001-09530-005
AU - Roberts, Charles
AU - Horton, Arthur MacNeill Jr.
T1 - Demographic effects on the Trail Making Test in amphetamine abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/09//
VL - 110
IS - 3-4
SP - 181
EP - 187
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, 20857
N1 - Accession Number: 2001-09530-005. PMID: 11912868 Partial author list: First Author & Affiliation: Roberts, Charles; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020130. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amphetamine; Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Neuropsychological Assessment. Minor Descriptor: Age Differences; Educational Attainment Level; Human Sex Differences; Racial and Ethnic Differences. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2001.
AB - Examined the relative influences of gender, ethnicity, age, and education level on a sample of amphetamine abusers in treatment on the Trail Making Test (TMT), a measure often used for cognitive impairment screening. Data on 185 Ss were drawn from the electronic files of the Drug Abuse Treatment Outcome Study (DATOS), a naturalistic, national, prospective cohort study of adults in drug abuse treatment programs. Results show that no demographic variables were statistically significant for either parts A or B of the TMT. It is noted that part B for education showed a trend toward statistical significance, but this may be a chance finding. R-square values for overall models were also negligible, suggesting that demographic effects on the TMT account for a very small degree of overall variance in terms of Ss' TMT performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - amphetamine abusers
KW - Trail Making Test
KW - gender
KW - ethnicity
KW - age
KW - education level
KW - drug abuse treatment
KW - 2001
KW - Amphetamine
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Neuropsychological Assessment
KW - Age Differences
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Racial and Ethnic Differences
KW - 2001
DO - 10.3109/00207450108986545
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09530-005&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-09530-006
AN - 2001-09530-006
AU - Roberts, Charles
AU - Horton, Arthur MacNeill Jr.
T1 - Demographic effects on the Trail Making Test in sedatives abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2001/09//
VL - 110
IS - 3-4
SP - 189
EP - 195
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, 20857
N1 - Accession Number: 2001-09530-006. PMID: 11912869 Partial author list: First Author & Affiliation: Roberts, Charles; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020130. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Neuropsychological Assessment; Sedatives. Minor Descriptor: Age Differences; Educational Attainment Level; Human Sex Differences; Racial and Ethnic Differences. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2001.
AB - Examined a sample of sedatives abusers on a neuropsychological measure often used for neuropsychological screening of cognitive impairment, the Trail Making Test (TMT), and to determine the relative influence of the variables of gender, ethnicity, age, and education level. Data were gathered from 72 patients enrolled in the Drug Abuse Treatment Outcome Study (DATOS), a naturalistic, national, prospective cohort study of adults in drug abuse treatment programs. Results show that none of the demographic variables, when considered singly, were statistically significantly related to TMT parts A and B. R-Square values for overall models were low, suggesting that ethnicity, education level, and age have combined effects on the TMT that account for very little variance in terms of the Ss' TMT performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marijuana abusers
KW - Trail Making Test
KW - gender
KW - ethnicity
KW - age
KW - education level
KW - drug abuse treatment
KW - 2001
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Neuropsychological Assessment
KW - Sedatives
KW - Age Differences
KW - Educational Attainment Level
KW - Human Sex Differences
KW - Racial and Ethnic Differences
KW - 2001
DO - 10.3109/00207450108986546
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09530-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Schreiber, G.B.
AU - Sanchez, A.M.
AU - Garratty, G.
AU - Nass, C.C.
AU - Tu, Y.
AU - Busch, M.P.
AU - Williams, A.E.
T1 - Mammalian Brain Consumption by U.S. Blood Donors: Brains Today, Deferred Tomorrow?
JO - Transfusion
JF - Transfusion
Y1 - 2001/09/02/Sep2001 Supplement 1
VL - 41
M3 - Article
SP - 35S
EP - 35S
SN - 00411132
AB - Background: The theoretical concern that new variant CJD could be transmitted by eating an infected animal's brain raises the possibility of mammalian brain consumption becoming a deferral criterion. No information concerning the brain consumption habits of donors exists. Methods: Findings from a 1998 anonymous mail survey of 92,581 US blood donors from eight geographically diverse blood centers were assessed using weighted chi-square and descriptive analysis. Results: Approximately 52,650 donors (57%) responded to the survey. Mammalian brains were ever consumed by 6.4% of donors, with a 3.6 fold regional variability in brain eating among the blood centers (ranging from 3.8% to 13.7%). Types of brains donors reported consuming included: cow (3.6%), hog (1.7%), sheep (1.0%), squirrel (0.3%), goat (0.2%), monkey (0.1%) and rabbit (<0.1%). Brain eating was highest among older (age 55+, 11%), foreign born (17%), male (8%), Asian (14%) and Hispanic (12%) donors. Among Asians, Chinese donors were the most likely to consume brains (15% US born; 28% foreign born), and among Hispanics, Mexicans had the highest rates of brain consumption (11% US born; 33% foreign born). Most brain consumers ate only one type of brain (84%) and reported a lifetime consumption of <5 times (62%). However, 1.4% of brain consumers did report eating brains >100 times in their lives. Squirrel and goat brain eaters were the most likely to report a lifetime consumption of >100 times (3% for each group). Conclusions: If mammalian brain consumption became a deferral criterion, regional impacts on donor deferral could be considerable. With the relationship between bovine spongiform encephalopathy from contaminated human food and new-variant Creutzfeldt-Jacob disease any deferral would probably be based on consumption of cow or sheep brains, 4.3% of donors. Thus, it is possible that more donors would be lost from this restriction than from the deferrals associated with residence in the UK (an estimated 2.2%). [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD donors -- Diseases
KW - CREUTZFELDT-Jakob disease -- Transmission
KW - UNITED States
N1 - Accession Number: 11257926; Schreiber, G.B. 1; Sanchez, A.M. 1; Garratty, G. 2; Nass, C.C. 3; Tu, Y. 1; Busch, M.P. 4; Williams, A.E. 5; Source Information: Sep2001 Supplement 1, Vol. 41, p35S; Subject: BLOOD donors -- Diseases; Subject: CREUTZFELDT-Jakob disease -- Transmission; Geographic Terms: UNITED States; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106983362
T1 - Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community.
AU - Groom AV
AU - Wolsey DH
AU - Naimi TS
AU - Smith K
AU - Johnson S
AU - Boxrud D
AU - Moore KA
AU - Cheek JE
AU - Groom, A V
AU - Wolsey, D H
AU - Naimi, T S
AU - Smith, K
AU - Johnson, S
AU - Boxrud, D
AU - Moore, K A
AU - Cheek, J E
Y1 - 2001/09/12/
N1 - Accession Number: 106983362. Language: English. Entry Date: 20021129. Revision Date: 20161112. Publication Type: journal article; CEU; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: U50/CCU511190//PHS HHS/United States. NLM UID: 7501160.
KW - Methicillin Resistance
KW - Staphylococcal Infections -- Epidemiology
KW - Rural Areas
KW - Community-Acquired Infections
KW - Record Review
KW - Retrospective Design
KW - Staphylococcus Aureus -- Drug Effects
KW - Native Americans
KW - United States
KW - Staphylococcal Infections -- Microbiology
KW - Staphylococcal Infections -- Drug Therapy
KW - Fisher's Exact Test
KW - Chi Square Test
KW - Kruskal-Wallis Test
KW - Confidence Intervals
KW - Relative Risk
KW - Staphylococcal Infections -- Risk Factors
KW - Education, Continuing (Credit)
KW - Funding Source
KW - Human
SP - 1201
EP - 1250
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 286
IS - 10
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Until recently, methicillin-resistant Staphylococcus aureus (MRSA) infections have been acquired primarily in nosocomial settings. Four recent deaths due to MRSA infection in previously healthy children in the Midwest suggest that serious MRSA infections can be acquired in the community in rural as well as urban locations.Objectives: To document the occurrence of community-acquired MRSA infections and evaluate risk factors for community-acquired MRSA infection compared with methicillin-susceptible S aureus (MSSA) infection.Design: Retrospective cohort study with medical record review.Setting: Indian Health Service facility in a rural midwestern American Indian community.Patients: Patients whose medical records indicated laboratory-confirmed S aureus infection diagnosed during 1997.Main Outcome Measures: Proportion of MRSA infections classified as community acquired based on standardized criteria; risk factors for community-acquired MRSA infection compared with those for community-acquired MSSA infection; and relatedness of MRSA strains, determined by pulsed-field gel electrophoresis (PFGE).Results: Of 112 S aureus isolates, 62 (55%) were MRSA and 50 (45%) were MSSA. Forty-six (74%) of the 62 MRSA infections were classified as community acquired. Risk factors for community-acquired MRSA infections were not significantly different from those for community-acquired MSSA. Pulsed-field gel electrophoresis subtyping indicated that 34 (89%) of 38 community-acquired MRSA isolates were clonally related and distinct from nosocomial MRSA isolates found in the region.Conclusions: Community-acquired MRSA may have replaced community-acquired MSSA as the dominant strain in this community. Antimicrobial susceptibility patterns and PFGE subtyping support the finding that MRSA is circulating beyond nosocomial settings in this and possibly other rural US communities.
SN - 0098-7484
AD - Indian Health Service National Epidemiology Program, 5300 Homestead Rd NE, Albuquerque, NM 87110, USA
AD - National Epidemiology Program, Indian Health Service Headquarters, Albuquerque, NM
U2 - PMID: 11559265.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106983362&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106943226
T1 - RN appointed to White House Commission on Complementary Medicine.
AU - Sparber A
Y1 - 2001/09/24/2001 Sep 24
N1 - Accession Number: 106943226. Language: English. Entry Date: 20020726. Revision Date: 20150711. Publication Type: Journal Article; interview. Journal Subset: Nursing; USA. NLM UID: 9892046.
KW - Alternative Therapies
KW - Nursing Leaders
SP - 43
EP - 43
JO - Nursing Spectrum -- Illinois & Indiana Edition
JF - Nursing Spectrum -- Illinois & Indiana Edition
JA - NURS SPECTRUM (CHICAGO ILLINOIS INDIANA)
VL - 14
IS - 19
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
AD - Captain, US Public Health Service, Psychiatric Consultation Liaison Nurse, Author, and Investigator of CAM, National Institutes of Health Clinical Center, Nursing Department, Bethesda, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106903800
T1 - Telemedicine: follow the money.
AU - Puskin DS
Y1 - 2001/09/30/2001 Sep 30
N1 - Accession Number: 106903800. Language: English. Entry Date: 20020301. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9806525.
KW - Telehealth -- Economics
KW - Telehealth -- Legislation and Jurisprudence -- United States
KW - Insurance, Health, Reimbursement -- Legislation and Jurisprudence -- United States
KW - Medicare
KW - Budgets -- Legislation and Jurisprudence -- United States
KW - United States Centers for Medicare and Medicaid Services
KW - Government Regulations
KW - Health Services Accessibility
KW - Current Procedural Terminology
KW - Remote Consultation
KW - Reimbursement Mechanisms
KW - Home Health Care
KW - Telenursing
KW - United States
SP - 13p
EP - 13p
JO - Online Journal of Issues in Nursing
JF - Online Journal of Issues in Nursing
JA - ONLINE J ISSUES NURS
VL - 6
IS - 3
CY - Silver Spring, Maryland
PB - American Nurses Association
AB - Until the late 1990s,e private and public third-party payers generally did not have explicit policies to pay for telehealth services. The Balanced Budget Act of 1997 signaled a significant change in Medicare payment policies opening the door for telemedicine reimbursement. This article traces the development of current Medicare telemedicine payment policies, beginning with the BBA of 1997 and including current medicare payment legislation. Issues related to telemedicine payment by both Medicare and other third party payers are presented; implication for the future, and the role of the nursing community are discussed. © 2001 Online Journal of Issues in Nursing. Article published September 30, 2001
SN - 1091-3734
AD - Director, Office for the Advancement of Telehealth, US Health Resources and Services Administration (HRSA)
U2 - PMID: 11936941.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106903800&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106903799
T1 - Health information privacy protection: crisis or common sense?
AU - Kumekawa JK
Y1 - 2001/09/30/2001 Sep 30
N1 - Accession Number: 106903799. Language: English. Entry Date: 20020301. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9806525.
KW - Telehealth
KW - Patient Record Systems
KW - Medical Records -- Legislation and Jurisprudence -- United States
KW - Privacy and Confidentiality -- Legislation and Jurisprudence -- United States
KW - Health Insurance Portability and Accountability Act
KW - Government Regulations
KW - Access to Information
KW - Organizational Compliance
KW - Data Security
KW - Risk Management
KW - Internet
KW - United States
SP - 14p
EP - 14p
JO - Online Journal of Issues in Nursing
JF - Online Journal of Issues in Nursing
JA - ONLINE J ISSUES NURS
VL - 6
IS - 3
CY - Silver Spring, Maryland
PB - American Nurses Association
AB - Concerns about the protection of personally identifiable information are not unique to the health care industry; however, consumers view their medical records as more 'private' than other information, such as financial data, because involuntary disclosure can affect jobs or health insurance status. This paper briefly touches upon new sweeping federal privacy standards mandated under the Health Insurance Portability and Accountability Act of 1996 (HIPAA). The article outlines who and what is covered under the new rules, considers how practitioners can approach compliance with common sense, addresses concerns related to risk management, discusses consumer health privacy issues, and notes the difficulty of evaluating these rules and regulations. The article also looks at some unique privacy issues facing telemedicine and telehealth practitioners. © 2001 Online Journal of Issues in Nursing. Article published September 30, 2001
SN - 1091-3734
AD - Director of Policy, Office for the Advancement of Telehealth (OAT), Department of Health and Human Services' Health Resources and Services Administration
U2 - PMID: 11936942.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106903799&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Milberg, John
AU - Sharma, Rupa
AU - Scott, Floretta
AU - Conviser, Richard
AU - Marconi, Katherine
AU - Parham, Deborah
T1 - Factors Associated with Delays in Accessing HIV Primary Care in Rural Arkansas.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2001/10//
VL - 15
IS - 10
M3 - Article
SP - 527
EP - 532
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - While debate continues at what stage of human immunodeficiency virus (HIV) disease to begin combination antiretroviral therapy, a number of clinical and public health benefits are linked to early entry into primary care soon after first testing HIV positive. However, HIV-infected patients continue to test late and delay entry into care. We used routinely collected demographic and clinical information to examine which factors are associated with delays in seeking care in a predominantly rural, economically poor area of Arkansas. The study population is 75% African American and male and 70% lack health insurance; nearly one fourth were referred from prison. At diagnosis, two thirds of the population had CD4 counts below 500 cells per microliter. Days from initial HIV diagnosis to entry into care declined from a median of 178 in 1994 to 24 in 1998. In 1998, 75% of the population entered into primary care within 2 months of diagnosis. However, CD4 counts at HIV diagnosis also declined in this period, from a median of 427 in 1995 to 208 cells per microliter in 1998. More recent year of diagnosis was associated with a shorter delay in seeking care; males, and individuals lacking health insurance took significantly longer to enter into care than females and those with insurance, respectively. Our univariate finding of extensive delays in seeking care in the prison population did not hold in the multivariate analysis. We found significant delays in time to initial HIV diagnosis, and further considerable delays in males and those lacking health insurance in the time taken to enter into primary care. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - HIV infections
KW - Primary health care
KW - Arkansas
KW - United States
N1 - Accession Number: 5523192; Milberg, John 1; Sharma, Rupa 2; Scott, Floretta 3; Conviser, Richard 1; Marconi, Katherine 1; Parham, Deborah 1; Affiliations: 1: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland; 2: Arkansas Department of Health, Little Rock, Arkansas; 3: Jefferson Comprehensive Care System, Inc., Pine Bluff, Arkansas; Issue Info: Oct2001, Vol. 15 Issue 10, p527; Subject Term: HIV-positive persons -- Medical care; Subject Term: HIV infections; Subject Term: Primary health care; Subject: Arkansas; Subject: United States; Number of Pages: 6p; Document Type: Article
L3 - 10.1089/108729101753205694
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=5523192&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106893811
T1 - Factors associated with delays in accessing HIV primary care in rural Arkansas.
AU - Milberg J
AU - Sharma R
AU - Scott F
AU - Conviser R
AU - Marconi K
AU - Parham D
Y1 - 2001/10//
N1 - Accession Number: 106893811. Language: English. Entry Date: 20020125. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - Health Services Accessibility -- Arkansas
KW - HIV Infections -- Arkansas
KW - Treatment Delay -- Arkansas
KW - Arkansas
KW - CD4 Lymphocyte Count
KW - Descriptive Statistics
KW - Descriptive Research
KW - Time Factors
KW - Record Review
KW - Databases
KW - AIDS Serodiagnosis
KW - Univariate Statistics
KW - Multivariate Analysis
KW - Socioeconomic Factors
KW - Convenience Sample
KW - Wilcoxon Signed Rank Test
KW - Male
KW - Female
KW - Human
SP - 527
EP - 532
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 15
IS - 10
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
AD - Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, Parklawn Bldg, Room 7-90, 5600 Fishers Lane, Rockville, MD 20857; jmilberg@hrsa.gov
U2 - PMID: 11689140.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106532207
T1 - Retrospective analysis of mortalities associated with medication errors.
AU - Phillips J
AU - Beam S
AU - Brinker A
AU - Holquist C
AU - Honig P
AU - Lee LY
AU - Pamer C
Y1 - 2001/10//2001 Oct 1
N1 - Accession Number: 106532207. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Medication Errors -- Mortality
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Child
KW - Convenience Sample
KW - Databases
KW - Descriptive Research
KW - Descriptive Statistics
KW - Drugs, Prescription
KW - Female
KW - Male
KW - Medication Errors -- Classification
KW - Medication Errors -- Etiology
KW - Middle Age
KW - Record Review
KW - Reports
KW - Retrospective Design
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 1835
EP - 1841
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 58
IS - 19
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - The types, causes, contributing factors, and patient demographics of fatal medication errors were reviewed. Case reports of medication errors from hospitals, ambulatory care settings, and patients' homes that were entered in FDA's Adverse Event Reporting System during 1993-98 were the source of information on fatal medication errors. Each report was classified using predefined criteria and a taxonomy developed by the National Coordinating Council for Medication Error Reporting and Prevention. The types, causes, contributing factors, and patient demographics were identified, and the causality of each case was assessed to prevent future fatalities. The data indicated 5,366 medication error reports. Fifty-nine reports were excluded and classified as duplicate reports or intentional overdoses. Of the remaining medication error reports, 68.2% resulted in serious patient outcomes and 9.8% were fatal. Of the 469 fatal medication error reports, 48.6% occurred in patients over 60 years. The most common types of errors resulting in patient death involved administering an improper dose (40.9%), administering the wrong drug (16%), and using the wrong route of administration (9.5%). The most common causes of errors were performance and knowledge deficits (44%) and communication errors (15.8%). Fatal medication errors accounted for approximately 10% of medication errors reported to FDA and were most frequently the result of improper dosing of the intended drug and administration of an incorrect drug. A review of case reports of medication errors from 1993 to 1998 yielded information on the most frequent causes of and contributing factors involved in fatal medication errors.
SN - 1079-2082
AD - Associate Director, Office of Post-Marketing Drug Risk Assessment, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, HFD-400 Room 15B03, 5600 Fishers Lane, Rockville, MD 20857; phillipsj@cder.fda.gov
U2 - PMID: 11596700.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Bunyavanich, Supinda
AU - Walkup, Ruth B.
T1 - US Public Health Leaders Shift Toward a New Paradigm of Global Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/10//
VL - 91
IS - 10
M3 - Editorial
SP - 1556
EP - 1558
PB - American Public Health Association
SN - 00900036
AB - The authors provides information on research which determined the theoretical and practical associations of international health leaders in government, nongovernmental, professional, multilateral and academic organizations. The research held discussions about the concepts fundamental to globalization of health and the difference between international and global health approaches. They also addressed ethical concerns about health disparities and national sovereignty from academics, the World Bank advisor, the Institute of Medicine advisor and health association representatives.
KW - World health
KW - Public health research
KW - Globalization
KW - Health disparities
KW - Medical ethics
KW - Institute of Medicine (U.S.)
N1 - Accession Number: 5270394; Bunyavanich, Supinda 1; Walkup, Ruth B. 1; Email Address: rwalkup@osophs.dhhs.gov; Affiliations: 1: Office of International and Refugee Health, US Department of Health and Human Services, Rockville, Md.; Issue Info: Oct2001, Vol. 91 Issue 10, p1556; Thesaurus Term: World health; Thesaurus Term: Public health research; Subject Term: Globalization; Subject Term: Health disparities; Subject Term: Medical ethics ; Company/Entity: Institute of Medicine (U.S.); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 2090
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HONG LI
AU - QIONGYU CHEN
AU - SHIEN LI
AU - WU YAO
AU - LINGHONG LI
AU - XIANGLIN SHI
AU - LIYING WANG
AU - CASTRANOVA, VINCE
AU - VALLYATHAN, VAL
AU - ERNST, ERIK
AU - CHEN CHEN
T1 - Effect of Cr(VI) Exposure on Sperm Quality: Human and Animal Studies.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2001/10//
VL - 45
IS - 7
M3 - Article
SP - 505
EP - 511
SN - 00034878
AB - The semen status of male workers occupationally exposed to hexavalent chromium(VI) was investigated. Sperm counts from exposed workers were 47.05±2.13×106/ml and those from control group 88.96±3.40×106/ml. Sperm motility decreased from 81.92±0.41% for the control group to 69.71±0.93% for the exposed workers. The levels of zinc, lactate dehydrogenase (LDH), and lactate dehydrogenase C4 isoenzyme (LDH-x) in seminal plasma for the exposed workers were 1.48±0.07 μmol/ml, 1.05±0.02×103 U, and 0.47±0.01×103 U, respectively, which were significantly lower than those of 5.72±0.15 μmol/ml, 1.49±0.02×103 U, and 0.78±0.15×103 U for the control group, respectively. Follicle stimulating hormone (FSH) (7.34±0.34×10−3 IU/ml) in serum from the exposed workers was significantly higher than that (2.41±0.08×10−3 IU/ml) from the control group. On the other hand, there were no significant differences in semen volume, semen liquefaction time, luteinizing hormone (LH) level in serum, and Cr concentration in both serum and seminal plasma between the exposed workers and the control group. Feeding Cr(VI) to rats significantly reduced the epididymal sperm counts from 87.40±3.85×106/g epididymis in control group to 21.40±1.20×106/g epididymis at a CrO3 dose of 10 mg/kg body weight and to 17.48±1.04×106/g epididymis at a CrO3 dose of 20 mg/kg body weight. Exposure of rats to Cr(VI) also significantly increased the sperm abnormality from 2.75±0.06% in the control group to 6.68±0.32% in the exposed group at a CrO3 dose of 10 mg/kg body and to 7.6±0.15% at a CrO3 dose of 20 mg/kg body weight. In exposed rats, there was visible disruption in germ cell arrangement near the walls of the seminiferous tubules. The diameters of seminiferous tubules in exposed rats were smaller. These results suggest that occupational exposure to chromium(VI) leads to alteration of semen status and may affect the reproductive success of exposed workers. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Industrial hygiene
KW - Spermatozoa
KW - Luteinizing hormone
KW - Exocrine glands -- Secretions
KW - Weight gain
KW - animals
KW - Cr(V) exposure
KW - humans
KW - reproductive toxicology
KW - sperm quality
N1 - Accession Number: 44593372; HONG LI 1; QIONGYU CHEN 1; SHIEN LI 1; WU YAO 1; LINGHONG LI 1; XIANGLIN SHI 2; Email Address: xas0@cdc.gov; LIYING WANG 2; CASTRANOVA, VINCE 2; VALLYATHAN, VAL 2; ERNST, ERIK 3; CHEN CHEN 1; Affiliations: 1: Department of Occupational Health, College of Public Health, Henan Medical University, Zhengzhou, Henan 450052, People's Republic of China; 2: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown WV 26505, USA; 3: Center of Reproductive Toxicology, University of Aarhust, DK-8000 Aarhus C, Denmark; Issue Info: Oct2001, Vol. 45 Issue 7, p505; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Subject Term: Spermatozoa; Subject Term: Luteinizing hormone; Subject Term: Exocrine glands -- Secretions; Subject Term: Weight gain; Author-Supplied Keyword: animals; Author-Supplied Keyword: Cr(V) exposure; Author-Supplied Keyword: humans; Author-Supplied Keyword: reproductive toxicology; Author-Supplied Keyword: sperm quality; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 107880015
T1 - Key Components of Care for Women With Gestational Diabetes.
AU - Reader, Diane
AU - Sipe, Melanie
Y1 - 2001///Fall2001
N1 - Accession Number: 107880015. Language: English. Entry Date: 20140122. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913432.
KW - Diabetes Mellitus, Gestational -- Diet Therapy
KW - Diabetic Diet -- In Pregnancy
KW - Diabetes Education -- In Pregnancy
KW - Glycemic Control
KW - Female
KW - Pregnancy
KW - Blood Glucose Self-Monitoring
KW - Dietary Carbohydrates
KW - Energy Intake
KW - Weight Gain
KW - Snacks
KW - Office Visits
KW - Postnatal Care
KW - Practice Guidelines
KW - Dietitians
SP - 188
EP - 191
JO - Diabetes Spectrum
JF - Diabetes Spectrum
JA - DIABETES SPECTRUM
VL - 14
IS - 4
CY - Alexandria, Virginia
PB - American Diabetes Association
SN - 1040-9165
AD - Manager, health professional education, International Diabetes Center, Minneapolis, Minn.
AD - Diabetes dietitian, Claremore Diabetes Program of the Indian Health Service, Claremore, Okla.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107880015&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106966734
T1 - The structure of self-rated health among community-dwelling older adults with stroke.
AU - Han B
AU - Small BJ
AU - Haley WE
Y1 - 2001/10//
N1 - Accession Number: 106966734. Language: English. Entry Date: 20021011. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8000128.
KW - Depression -- Epidemiology -- In Old Age
KW - Stroke Patients -- Psychosocial Factors -- In Old Age
KW - Health Status -- In Old Age
KW - Cross Sectional Studies
KW - LISREL
KW - Self Report
KW - Community Living -- In Old Age
KW - Geriatric Functional Assessment
KW - Center for Epidemiological Studies Depression Scale
KW - Neuropsychological Tests
KW - Data Analysis, Statistical
KW - Data Analysis Software
KW - Chi Square Test
KW - P-Value
KW - Descriptive Statistics
KW - Aged
KW - Human
SP - 1
EP - 15
JO - Home Health Care Services Quarterly
JF - Home Health Care Services Quarterly
JA - HOME HEALTH CARE SERV Q
VL - 20
IS - 4
PB - Taylor & Francis Ltd
AB - OBJECTIVE: To examine whether depressive symptomatology is a third fundamental component of the structure of self-rated health, in addition to two other components (physical disease and functional disability) among community-dwelling older adults with stroke. DATA SOURCES AND STUDY SETTING: A total of 591 community-dwelling older adults with stroke were identified from the 1993 Asset and Health Dynamics among the Oldest-Old (AHEAD) national survey of community-dwelling older adults. STUDY DESIGN: A cross-sectional study. Structural equation modeling was applied to compare a widely used two-factor model of self-rated health with a model adding depression as a third possible factor. PRINCIPLE FINDINGS: The hypothesized three-factor model explained additional 21% more variance of self-rated health of older adults with stroke (R2 = 79%, NNFI = 0.95, CFI = 0.96, RMSEA = 0.04) as compared with the two-factor biomedical model (R2 = 58%, NNFI = 0.95, CFI = 0.98, RMSEA = 0.05). The three-factor model was statistically different from the two-factor model. CONCLUSIONS: Greater attention should be given to the theoretical structure of self-rated health of older adults with stroke, particularly, the significant impact of depression on their self-rated health.
SN - 0162-1424
AD - Special Populations Research Branch, Division of Programs for Special Populations, Bureau of Primary Health Care, Health Resources and Services Administration, 4350 East-West Highway, Room 9-3 A1, Bethesda, MD 20814; bhan@hrsa.agov
U2 - PMID: 12068964.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106849454
T1 - Pharmacokinetic-pharmacodynamic modeling of rivastigmine, a cholinesterase inhibitor, in patients with Alzheimer's disease.
AU - Gobburu JVS
AU - Tammara V
AU - Lesko L
AU - Jhee SS
AU - Sramek JJ
AU - Cutler NR
AU - Yuan R
Y1 - 2001/10//
N1 - Accession Number: 106849454. Language: English. Entry Date: 20030711. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mini-Mental Status Examination (MMSE) (Folstein et al). NLM UID: 0366372.
KW - Alzheimer's Disease -- Drug Therapy
KW - Cholinesterase Inhibitors -- Therapeutic Use
KW - Acetylcholine -- Drug Effects
KW - Aged, 80 and Over
KW - Biological Availability
KW - Cerebrospinal Fluid -- Drug Effects
KW - Chi Square Test
KW - Chromatography, Gas
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Middle Age
KW - Post Hoc Analysis
KW - Psychological Tests
KW - Mass Spectrometry
KW - Human
SP - 1082
EP - 1090
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 41
IS - 10
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Rivastigmine is a cholinersterase inhibitor approved recently for the treatment of Alzheimer's disease (AD). The objective of this study is to characterize the pharmacokinetics-pharmacodynamics of rivastigmine in patients with AD. Eighteen AD patients received doses ranging from 1 to 6 mg bid for about 11 weeks. Rivastigmine and its active (major) metabolite (ZNS 114-666, also called NAP 226-90), plasma, and cerebrospinal fluid (CSF) concentrations were determined together with the AChE activity and computerized neuropsychological test battery (CNTB) scores. Nonlinear mixed-effects modeling of pharmacokinetic and pharmacodynamic data was conducted using NONMEM. Rivastigmine and its metabolite exhibited dose-disproportional pharmacokinetics. The apparent clearance and volume of distribution (plasma) of rivastigmine were estimated to be 120 L/h and 236 L, respectively. The relative bioavailability at the 6 mg dose was about 140%. The metabolite had a clearance of about 100 L/h and a volume of distribution of 256 L. The kinetics of the parent and metabolite in CSF showed an equilibration half-life of about 0.2 and 0.5 hours, respectively. The metabolite levels in CSF correlated very well with the acetylcholinesterase inhibition, with a ZNS 114-666 concentration of about 5.4 microg/L required for half-maximal inhibition of acetylcholinesterase activity. No statistically significant correlation of the CNTB scores with enzyme inhibition, parent or metabolite concentration (plasma/CSF), or rivastigmine dose could be established. The PK-PD model presented in this study can provide valuable information to optimize the drug development of rivastigmine and other related compounds and also in rationalizing dosing recommendations.
SN - 0091-2700
AD - Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland
U2 - PMID: 11583476.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106935127
T1 - Health disparities among older women: identifying opportunities to improve quality of care and functional health outcomes.
AU - Bierman AS
AU - Clancy CM
Y1 - 2001///2001 Fall
N1 - Accession Number: 106935127. Language: English. Entry Date: 20020628. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503064.
KW - Chronic Disease -- Epidemiology
KW - Health Services for the Aged -- Standards
KW - Quality Assurance
KW - Preventive Health Care -- Standards
KW - Female
KW - Economic Aspects of Illness
KW - Health Policy
KW - United States
KW - Aging
KW - Minority Groups
KW - Socioeconomic Factors
KW - Aged
KW - Conceptual Framework
SP - 155
EP - 188
JO - Journal of the American Medical Women's Association
JF - Journal of the American Medical Women's Association
JA - J AM MED WOMENS ASSOC
VL - 56
IS - 4
CY - Reston, Virginia
PB - American Medical Women's Association
AB - Older women experience a high burden of chronic illness, disability, and comorbidity, and this burden is highest among socioeconomically disadvantaged and minority women. The consequences of a mismatch between the organization, delivery, and financing of health care for older women and their actual needs fall disproportionately on low-income and minority women. New sources of data, such as the Medicare Health Outcomes Survey, a new quality measure for Medicare+Choice plans, will provide valuable information to practitioners about the health and functioning of older women in general and about socioeconomically disadvantaged and minority women in particular. This information can be used to develop and implement interventions to improve the quality and outcomes of care for vulnerable subgroups of older women. There is cause for optimism that by improving the quality of clinical preventive services and the management of common chronic conditions and geriatric syndromes it will be possible to improve functional health outcomes, prevent or postpone disability, and extend active life expectancy for all older women while making progress toward eliminating health disparities among the most disadvantaged.
SN - 0098-8421
AD - Senior Research Physician, Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 11759783.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106935127&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106935154
T1 - Federal report. Office of Women's Health, Food and Drug Administration: future directions for women's health.
AU - Wood SF
Y1 - 2001///2001 Fall
N1 - Accession Number: 106935154. Language: English. Entry Date: 20020628. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503064.
KW - Women's Health
KW - Women's Rights -- Trends -- United States
KW - United States Food and Drug Administration
KW - Clinical Trials
KW - Female
KW - Leadership
KW - Organizational Policies
KW - United States
SP - 197
EP - 198
JO - Journal of the American Medical Women's Association
JF - Journal of the American Medical Women's Association
JA - J AM MED WOMENS ASSOC
VL - 56
IS - 4
CY - Reston, Virginia
PB - American Medical Women's Association
AB - The Office of Women's Health serves as an advocate for women's health throughout the Food and Drug Administration (FDA). Through and policies, the Office supports research in gender-related issues in the regulation and use of drugs, devices, biologics, and foods; initiates outreach and disseminates health information to women; provides leadership in increasing the number of women and appropriate data analysis in all phases of clinical trials; and promotes women's health in FDA actions. This article summarizes current activities and future directions in women's health at the FDA.
SN - 0098-8421
AD - Director, Office of Women's Health, Food and Drug Administration
U2 - PMID: 11759792.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Overpeck, Md
AU - Brenner, Ra
AU - Cosgrove, C
AU - Trumble, Ac
AU - Kochanek, K
AU - MacDorman, M
T1 - Risk factors associated with national underascertainment of unexpected infant deaths.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2001/10//
VL - 15
IS - 4
M3 - Article
SP - A25
EP - A25
SN - 02695022
AB - Examines the risk factors associated with the underascertainment of abuse-related infant deaths in the United States. National estimates of unexpected infant deaths; Implication of unexpected infant deaths for the assignment of the cause of death; Efforts for prevention of infant abuse and unqualified causes of death.
KW - INFANT mortality
KW - PREVENTION of child abuse
KW - SUDDEN infant death syndrome
KW - UNITED States
N1 - Accession Number: 5396164; Overpeck, Md; Brenner, Ra 1; Cosgrove, C 1; Trumble, Ac 1; Kochanek, K 1; MacDorman, M 1; Source Information: Oct2001, Vol. 15 Issue 4, pA25; Subject: INFANT mortality; Subject: PREVENTION of child abuse; Subject: SUDDEN infant death syndrome; Geographic Terms: UNITED States; Number of Pages: 1p; Document Type: Article
L3 - 10.1046/j.1365-3016.2001.00381-77.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Park, Ch
AU - Overpeck, Md
AU - Kogan, Md
T1 - Black-white differences in health care utilization among children with frequent ear infections.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2001/10//
VL - 15
IS - 4
M3 - Article
SP - A25
EP - A26
SN - 02695022
AB - Examines the differences in the health care utilization between black and white children with frequent ear infections in the United States. Absence of difference on the prevalence of ear infection between white and black children; Delayed health care among black children; Percentage of ear surgeries between black and white children.
KW - MEDICAL care -- United States
KW - EAR -- Infections
KW - BLACK children
KW - WHITE children
KW - UNITED States
N1 - Accession Number: 5396162; Park, Ch; Overpeck, Md 1; Kogan, Md 1; Source Information: Oct2001, Vol. 15 Issue 4, pA25; Subject: MEDICAL care -- United States; Subject: EAR -- Infections; Subject: BLACK children; Subject: WHITE children; Geographic Terms: UNITED States; Number of Pages: 2p; Document Type: Article
L3 - 10.1046/j.1365-3016.2001.00381-79.x
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DB - hch
ER -
TY - JOUR
ID - 106896248
T1 - Improving parent knowledge about antibiotics: a video intervention.
AU - Bauchner H
AU - Osganian S
AU - Smith K
AU - Triant R
Y1 - 2001/10//
N1 - Accession Number: 106896248. Language: English. Entry Date: 20020201. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Funded by Grant #5 R44 AI40815-03 from the National Institutes of Allergy and Infectious Disease. NLM UID: 0376422.
KW - Parents -- Education
KW - Videorecording
KW - Clinical Trials
KW - Research Subject Recruitment
KW - Descriptive Statistics
KW - Questionnaires
KW - Summated Rating Scaling
KW - Chi Square Test
KW - Analysis of Covariance
KW - Health Knowledge -- Evaluation
KW - Health Beliefs -- Evaluation
KW - Adult
KW - Funding Source
KW - Human
SP - 845
EP - 850
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 108
IS - 4
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - Objective. To determine whether an educational video could improve parent knowledge, beliefs, and behaviors about the appropriate use of oral antibiotics. Study Design. A randomized, controlled trial was conducted in an urban primary care clinic and a suburban pediatric practice. Parents were randomly assigned to the intervention or control groups. Parents in the intervention group were asked to view a 20-minute video, specifically developed for this project, over a 2-month period, and given a brochure about antibiotics. Parent knowledge, beliefs, and behaviors were assessed at the time of enrollment and then by telephone 2 months later. Results. A total of 193 (94%) of 206 parents completed the study. The groups were equivalent with respect to all important baseline characteristics. No differences were found for adjusted posttest means between the intervention and control groups for knowledge, beliefs, or behavior. For example, the intervention group scored 8.04 on the knowledge questionnaire (11 true-false questions), compared with 7.82 for the control group. Subgroup analysis, based on site of enrollment, indicated that families in the intervention group from the primary care urban clinic improved their knowledge score (6.03 to 6.92) and were more likely to report that there were problems with children receiving too many antibiotics (intervention 67% vs control 34%). Conclusion. Overall, this video had only a modest effect on parent knowledge, beliefs, and self-reported behaviors regarding oral antibiotics. We believe that any campaign promoting the judicious use of oral antibiotics must use a multifaceted approach and target both parents and physicians.
SN - 0031-4005
AD - Child and Adolescent Scholar is Residence, Agency for Healthcare Research and Quality, 6010 Executive Blvd, Suite 201, Rockville, MD 20852. E-mail: howard.bauchner@bmc.org
U2 - PMID: 11581434.
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DB - rzh
ER -
TY - JOUR
AU - Papaconstantinou, Andriana D.
AU - Fisher, Benjamin R.
AU - Umbreit, Thomas H.
AU - Goering, Peter L.
AU - Lappas, Nicholas T.
AU - Brown, Ken M.
T1 - Effects of β-Estradiol and Bisphenol A on Heat Shock Protein Levels and Localization in the Mouse Uterus Are Antagonized by the Antiestrogen ICI 182,780.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/10//
VL - 63
IS - 2
M3 - Article
SP - 173
EP - 180
PB - Oxford University Press / USA
SN - 10966080
AB - Bisphenol A (BPA) exhibits many estrogen-like effects in the rodent uterus, but not all of these can be attenuated by antiestrogens. This suggests the involvement of alternate pathways of BPA action that do not involve the estrogen receptor (ER). An examination of the in vivo effects of BPA on uterine gene expression and protein levels should contribute to an understanding of its mechanism of action. In this study we examined the dose-related effects of BPA on levels of a suite of heat shock proteins (hsps) and on the localization of hsp90α, a chaperone of the ER, in uteri of ovariectomized B6C3F1 mice and compared these effects with those of β-estradiol (E2). The antiestrogen ICI 182,780 (ICI) was co-administered with BPA or E2 in order to examine the potential role of the ER. BPA, although less potent than E2, increased hsp90α and grp94 to similar levels, but was much less effective than E2 in increasing levels of hsp72. Treatment with 100 mg BPA/kg/day or 2 μg E2/kg/day increased hsp90α to 300% of control levels and altered its tissue expression pattern. In uteri of corn oil (control)-treated mice, hsp90α predominantly localized in the cytoplasm and nuclei of epithelial cells. Upon treatment with BPA or E2 there was increased intensity of staining in the stroma and myometrium, and in the epithelium hsp90α was localized almost exclusively in the cytoplasm. The effects of BPA or E2 on hsp levels and hsp90α localization were attenuated by ICI. These results suggest an involvement of the ER in BPA- and E2-induced increases in uterine levels of hsp90α, grp94, and hsp72, and localization of hsp90α. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytoplasm
KW - Bisphenol A
KW - Estrogen
KW - Rats as laboratory animals
KW - Proteins
KW - Heat shock proteins
KW - β-estradiol (E2)
KW - β-estradiol (E2)
KW - B6C3F1 mouse
KW - bisphenol A (BPA)
KW - estrogen receptor (ER)
KW - heat shock proteins
KW - hsp90α localization
KW - hsp90α localization
KW - ICI 182,780 (ICI)
KW - ICI 182;780 (ICI)
KW - uterus
N1 - Accession Number: 44406205; Papaconstantinou, Andriana D. 1; Fisher, Benjamin R. 2,3; Umbreit, Thomas H. 2; Goering, Peter L. 2; Lappas, Nicholas T. 4; Brown, Ken M. 1; Email Address: kmb@gwu.edu; Affiliations: 1: Department of Biological Sciences, George Washington University, Washington, D.C. 20052; 2: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20857; 3: Covance Laboratories, 9200 Leesburg Pike, Vienna, VA 22182; 4: Forensic Sciences Department, George Washington University, Washington, D.C. 20052; Issue Info: Oct2001, Vol. 63 Issue 2, p173; Thesaurus Term: Cytoplasm; Subject Term: Bisphenol A; Subject Term: Estrogen; Subject Term: Rats as laboratory animals; Subject Term: Proteins; Subject Term: Heat shock proteins; Author-Supplied Keyword: β-estradiol (E2); Author-Supplied Keyword: β-estradiol (E2); Author-Supplied Keyword: B6C3F1 mouse; Author-Supplied Keyword: bisphenol A (BPA); Author-Supplied Keyword: estrogen receptor (ER); Author-Supplied Keyword: heat shock proteins; Author-Supplied Keyword: hsp90α localization; Author-Supplied Keyword: hsp90α localization; Author-Supplied Keyword: ICI 182,780 (ICI); Author-Supplied Keyword: ICI 182;780 (ICI); Author-Supplied Keyword: uterus; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Color Photograph, 2 Diagrams, 3 Graphs; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Yazal, Jamal El
AU - Rao, Shashidhar N.
AU - Mehl, Adrea
AU - Slikker Jr., William
T1 - Prediction of Organophosphorus Acetylcholinesterase Inhibition Using Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Methods.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2001/10//
VL - 63
IS - 2
M3 - Article
SP - 223
EP - 232
PB - Oxford University Press / USA
SN - 10966080
AB - Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. In this light, molecular modeling studies were performed on a collection of organophosphorous acetylcholinesterase inhibitors by the combined use of conformational analysis and 3D-QSAR methods to rationalize their inhibitory potencies against the enzyme. The Catalyst program was used to identify the structural features in the group of 8 inhibitors whose IC50 values ranged from 0.34 nM to 1.2 μM. The 3-D pharmacophore models are characterized by at least one hydrogen bond acceptor site and 2–3 hydrophobic sites and demonstrate very good correlation between the predicted and experimental IC50 values. Our models can be useful in screening databases of organophosphorous compounds for their neurotoxicity potential via the inhibition of acetylcholinesterase. Also, the pharmacophores offer an additional means of designing AChE inhibitors as potential therapeutic agents for central nervous system diseases. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Neurotoxicology
KW - Organophosphorus compounds
KW - Acetylcholinesterase
KW - Enzymes
KW - Neurotransmitters
KW - Acetylcholine
KW - Catalysts
KW - 3-D pharmacophore
KW - conformation
KW - hydrogen bond acceptor
KW - hydrophobic
KW - hypothesis
KW - insecticides
N1 - Accession Number: 44406211; Yazal, Jamal El 1; Rao, Shashidhar N. 2; Mehl, Adrea 2; Slikker Jr., William 1; Email Address: wslikker@nctr.fda.gov; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, Arkansas, 72079; 2: Molecular Simulations, Inc., 9685 Scranton Road, San Diego, California 92121; Issue Info: Oct2001, Vol. 63 Issue 2, p223; Subject Term: Neurotoxicology; Subject Term: Organophosphorus compounds; Subject Term: Acetylcholinesterase; Subject Term: Enzymes; Subject Term: Neurotransmitters; Subject Term: Acetylcholine; Subject Term: Catalysts; Author-Supplied Keyword: 3-D pharmacophore; Author-Supplied Keyword: conformation; Author-Supplied Keyword: hydrogen bond acceptor; Author-Supplied Keyword: hydrophobic; Author-Supplied Keyword: hypothesis; Author-Supplied Keyword: insecticides; Number of Pages: 10p; Illustrations: 5 Color Photographs, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106976694
T1 - The isolation of antibiotic-resistant salmonella from retail ground meats.
AU - White DG
AU - Zhao S
AU - Sudler R
AU - Ayers S
AU - Friedman S
AU - Chen S
AU - McDermott PF
AU - McDermott S
AU - Wagner DD
AU - Meng J
Y1 - 2001/10/18/
N1 - Accession Number: 106976694. Language: English. Entry Date: 20021108. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by a grant from the Maryland Agricultural Experimental Station. NLM UID: 0255562.
KW - Salmonella
KW - Meat
KW - Drug Resistance, Microbial
KW - Funding Source
KW - District of Columbia
KW - Human
SP - 1147
EP - 1154
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 345
IS - 16
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Division of Animal and Food Microbiology Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD
U2 - PMID: 11642230.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106943596
T1 - The threat is real. Are you prepared for a terrorist attack?
AU - Stopford BM
Y1 - 2001/10/22/2001 Oct 22
N1 - Accession Number: 106943596. Language: English. Entry Date: 20020726. Revision Date: 20150711. Publication Type: Journal Article; brief item. Note: Published in multiple journals. Journal Subset: Nursing; USA. NLM UID: 9892046.
KW - Disaster Planning
KW - Terrorism
SP - 5
EP - 5
JO - Nursing Spectrum -- Illinois & Indiana Edition
JF - Nursing Spectrum -- Illinois & Indiana Edition
JA - NURS SPECTRUM (CHICAGO ILLINOIS INDIANA)
VL - 14
IS - 21
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
AD - Clinical Supervisor, Chief Nurse, US Public Health Service, Central US National Medical Response Team: Weapons of Mass Destruction
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106811298
T1 - Monitoring the safety net: data challenges for emergency departments.
AU - Weinick RM
AU - Burstin H
Y1 - 2001/11//
N1 - Accession Number: 106811298. Language: English. Entry Date: 20030228. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Emergency Service Information Systems
KW - Health Services Accessibility
KW - Quality Assessment
KW - Data Collection
SP - 1019
EP - 1021
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 8
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1069-6563
AD - Center for Primary Care Research, Agency for Healthcare Research and Quality, Rockville, MD; rweinick@ahrq.gov
U2 - PMID: 11691661.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109874770
T1 - The Surgeon General's call to action to promote sexual health and responsible sexual behavior.
AU - Satcher D
Y1 - 2001/11//2001 Nov-Dec
N1 - Accession Number: 109874770. Language: English. Entry Date: 20020517. Revision Date: 20151008. Publication Type: Journal Article; review. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 101090650.
KW - Sexual Health
KW - Sexuality
KW - Health Promotion
KW - Public Health
KW - Conceptual Framework
KW - Healthy People 2010
KW - Sexually Transmitted Diseases -- Epidemiology
KW - HIV Infections -- Epidemiology
KW - Sexual Abuse -- Epidemiology
KW - Pregnancy, Unplanned
KW - Pregnancy in Adolescence
KW - Abortion, Induced -- Trends
KW - Risk Factors
KW - Health Services Accessibility
KW - Contraception -- Utilization
KW - Community Programs
KW - School Health Services
KW - Sex Education
KW - Social Welfare
KW - Male
KW - Female
KW - Adolescence
KW - Adult
KW - Blacks
KW - Whites
KW - Hispanics
KW - United States
SP - 356
EP - 368
JO - American Journal of Health Education
JF - American Journal of Health Education
JA - AM J HEALTH EDUC
VL - 32
IS - 6
CY - Oxfordshire,
PB - Routledge
AB - I am introducing the Surgeon General's Call to Action to Promote Sexual Health and Responsible Sexual Behavior because we, as a nation, must address the significant public health challenges regarding the sexual health of our citizens. In recognition of these challenges, promoting responsible sexual behavior is included among the Surgeon General's public health priorities and is also one of the Healthy People 2010 Ten Leading Health Indicators for the Nation. Although it is important to acknowledge the many positive aspects of sexuality, we also need to understand that there are undesirable consequences as well-alarmingly high levels of sexually transmitted disease and HIV/AIDS infection, unintended pregnancy, abortion, sexual dysfunction, and sexual violence. These challenges can be met, but first we must find common ground and reach consensus on some important problems and their possible solutions. It is necessary to appreciate what sexual health is, that it is connected with both physical and mental health, and that it is important throughout the entire life span, not just the reproductive years. It is also important to recognize the responsibilities that individuals and communities have in protecting sexual health. The responsibility of well-informed adults as educators and role models for their children cannot be overstated. Issues around sexuality can be difficult to discuss-because they are personal and because there is great diversity in how they are perceived and approached. Yet, they greatly impact public health and, thus, it is time to begin that discussion and, to that end, this Surgeon General's Call to Action is offered as a framework. During its development we received a wide range of input and have identified several areas of common ground. A major responsibility of the Surgeon General is to provide the best available science based information to the American people to assist in protecting and advancing the health and safety of our nation. This report represents another effort to meet that responsibility.
SN - 1932-5037
AD - Assistant Secretary for Health and Human Services, United States Department of Health and Human Services
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DB - rzh
ER -
TY - JOUR
AU - Yu, Stella M.
AU - Alexander, Greg R.
AU - Schwalberg, Renee
AU - Kogan, Michael D.
T1 - Prenatal Care Use Among Selected Asian American Groups.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/11//
VL - 91
IS - 11
M3 - Article
SP - 1865
EP - 1868
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the predictors of 3 patterns of prenatal care use (no care, late initiation of care, and inadequate use after early initiation) for 4 Asian American ethnic groups in the United States. Methods. Single live births to US resident mothers of Chinese, Japanese, Korean, and Vietnamese ancestry (n = 273604) were selected from the 1992-1996 US natality files. Logistic regression was used to analyze the effects of maternal characteristics on the 3 use measures. Results. Korean Americans and Vietnamese Americans had the lowest levels of prenatal care use. Young or single motherhood, high parity for age, and low educational attainment were the main risk factors for low use. Conclusions. Considerable variability exists in prenatal care use among Asian American ethnic groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Prenatal care
KW - Obstetrics
KW - Preconception care
KW - Prenatal diagnosis
KW - Preventive health services
KW - Logistic regression analysis
KW - Immigrants -- United States
KW - United States
N1 - Accession Number: 5461040; Yu, Stella M. 1; Email Address: syu@hrsa.gov; Alexander, Greg R. 2; Schwalberg, Renee 3; Kogan, Michael D. 1; Affiliations: 1: Maternal and Child Health Bureau, Office of Data and Information Management, Rockville, Md.; 2: Department of Maternal and Child Health, School of Public Health, University of Alabama, Birmingham; 3: Maternal and Child Health Information Resource Center, Washington, DC; Issue Info: Nov2001, Vol. 91 Issue 11, p1865; Subject Term: Prenatal care; Subject Term: Obstetrics; Subject Term: Preconception care; Subject Term: Prenatal diagnosis; Subject Term: Preventive health services; Subject Term: Logistic regression analysis; Subject Term: Immigrants -- United States; Subject: United States; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 3568
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DB - eih
ER -
TY - JOUR
ID - 106980838
T1 - Prenatal care use among selected Asian American groups.
AU - Yu SM
AU - Alexander GR
AU - Schwalberg R
AU - Kogan MD
Y1 - 2001/11//
N1 - Accession Number: 106980838. Language: English. Entry Date: 20021122. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: R-GINDEX. NLM UID: 1254074.
KW - Prenatal Care -- Utilization
KW - Asians -- Psychosocial Factors
KW - Health Resource Utilization
KW - Ethnic Groups
KW - Chinese
KW - Japanese
KW - Koreans
KW - Vietnamese
KW - United States
KW - Pregnancy
KW - Female
KW - Vital Statistics
KW - Clinical Assessment Tools
KW - Chi Square Test
KW - Logistic Regression
KW - P-Value
KW - Odds Ratio
KW - Confidence Intervals
KW - Age Factors
KW - Marital Status
KW - Parity
KW - Educational Status
KW - Comparative Studies
KW - Adolescence
KW - Adult
KW - Human
SP - 1865
EP - 1868
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 91
IS - 11
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study examined the predictors of 3 patterns of prenatal care use (no care, late initiation of care, and inadequate use after early initiation) for 4 Asian American ethnic groups in the United States. METHODS: Single live births to US resident mothers of Chinese, Japanese, Korean, and Vietnamese ancestry (n = 273 604) were selected from the 1992-1996 US natality files. Logistic regression was used to analyze the effects of maternal characteristics on the 3 use measures. RESULTS: Korean Americans and Vietnamese Americans had the lowest levels of prenatal care use. Young or single motherhood, high parity for age, and low educational attainment were the main risk factors for low use. CONCLUSIONS: Considerable variability exists in prenatal care use among Asian American ethnic groups.
SN - 0090-0036
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18A-55, Rockville, MD 20857 (syu@hrsa.gov)
U2 - PMID: 11684617.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - ZHUANG, Z.
AU - HEARL, F. J.
AU - ODENCRANTZ, J.
AU - CHEN, W.
AU - CHEN, B. T.
AU - CHEN, J. Q.
AU - MCCAWLEY, M. A.
AU - GAO, P.
AU - SODERHOLM, S. C.
T1 - Estimating historical respirable crystalline silica exposures for Chinese pottery workers and iron/copper, tin, and tungsten miners.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2001/11//
VL - 45
IS - 8
M3 - Article
SP - 631
EP - 642
SN - 00034878
AB - Collaborative studies of Chinese workers, using over four decades of dust monitoring data, are being conducted by the National Institute for Occupational Safety and Health (NIOSH) and Tongji Medical University in China. The goal of these projects is to establish exposure–response relationships for the development of diseases such as silicosis or lung cancer in cohorts of pottery and mine workers. It is necessary to convert Chinese dust measurements to respirable silica measurements in order to make results from the Chinese data comparable to other results in the literature. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Universities & colleges
KW - Lungs -- Dust diseases
KW - Cancer
KW - China
KW - crystalline silica content
KW - exposure estimates
KW - mining dust
KW - respirable crystalline silica exposure
KW - silicosis
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 44594229; ZHUANG, Z. 1; Email Address: zaz3@cdc.gov; HEARL, F. J. 1; ODENCRANTZ, J. 1; CHEN, W. 2; CHEN, B. T. 1; CHEN, J. Q. 2; MCCAWLEY, M. A. 1; GAO, P. 1; SODERHOLM, S. C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Department of Labor Health and Occupational Diseases, Tongji Medical University,1 3 Hangkong Road, Wuhan, Hubei, People's Republic of China; Issue Info: Nov2001, Vol. 45 Issue 8, p631; Thesaurus Term: Occupational diseases; Subject Term: Universities & colleges; Subject Term: Lungs -- Dust diseases; Subject Term: Cancer; Subject: China; Author-Supplied Keyword: crystalline silica content; Author-Supplied Keyword: exposure estimates; Author-Supplied Keyword: mining dust; Author-Supplied Keyword: respirable crystalline silica exposure; Author-Supplied Keyword: silicosis ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 12p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rafii, F.
AU - Hehman, G.
AU - Lunsford, P.
T1 - Purification and characterization of an enzyme from Mycobacterium sp. Pyr-1, with nitroreductase activity and an N-terminal sequence similar to lipoamide dehydrogenase.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2001/11//
VL - 176
IS - 5
M3 - Article
SP - 381
EP - 385
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - Mycobacterium sp. Pyr-1 produces an enzyme with nitroreductase activity that reduces 1-nitropyrene and 4-nitrobenzoic acid to the corresponding aromatic amines. This enzyme was constitutive and required NADH; and its activity was enhanced by FAD. It was inhibited by antimycin A, dicumarol, and o-iodosobenzoic acid; and it was inactivated by ammonium sulfate precipitation. After purification to homogeneity, the protein produced a single band on native and SDS-polyacrylamide gels and had a single amino-terminal sequence. The N-terminal amino acid sequence was identical to the corresponding sequences of the lipoamide dehydrogenases of M. leprae, M. tuberculosis and Corynebacterium glutamicum. The amino-terminal sequence was also similar to lipoamide dehydrogenases from M. smegmatis and several other bacteria. The amino acid sequence of an internal peptide (12 of 13 amino acids) was nearly identical to the corresponding sequences of lipoamide dehydrogenases from M. leprae and M. tuberculosis and was similar to those of C. glutamicum, Streptomyces coelicolor and S. seoulensis. The data show that a unique lipoamide dehydrogenase in Mycobacterium sp. Pyr-1, which differs from classic (Type I) bacterial nitroreductases, reduces aromatic nitro compounds to aromatic amines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ammonium sulfate
KW - Bacteriology
KW - Mycobacterium
KW - Enzymes
KW - Amino acids
KW - Nitro compounds
KW - ADEPT
KW - Lipoamide dehydrogenase
KW - Nitroreductase
N1 - Accession Number: 15731442; Rafii, F. 1; Email Address: frafii@nctr.fda.gov; Hehman, G. 1; Lunsford, P. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson AR 72079, USA; Issue Info: Nov2001, Vol. 176 Issue 5, p381; Thesaurus Term: Ammonium sulfate; Thesaurus Term: Bacteriology; Subject Term: Mycobacterium; Subject Term: Enzymes; Subject Term: Amino acids; Subject Term: Nitro compounds; Author-Supplied Keyword: ADEPT; Author-Supplied Keyword: Lipoamide dehydrogenase; Author-Supplied Keyword: Nitroreductase; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/s002030100337
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15731442&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106932749
T1 - The effect of repeated ethylene oxide sterilization on the mechanical strength of synthetic absorbable sutures.
AU - Woods TO
AU - Brown SA
AU - Merritt K
AU - McNamee SG
AU - Hitchins VM
AU - Woods, T O
AU - Brown, S A
AU - Merritt, K
AU - McNamee, S G
AU - Hitchins, V M
Y1 - 2001/11//2001 Nov-Dec
N1 - Accession Number: 106932749. Language: English. Entry Date: 20020621. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Sutures
KW - Ethylene Oxide
KW - Sterilization and Disinfection
KW - Disposable Equipment
KW - Tensile Strength
KW - T-Tests
KW - Human
SP - 391
EP - 394
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 35
IS - 6
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - The purpose of this study was to determine the effect of repeated ethylene oxide sterilization using a standard clinical protocol on sutures, a type of medical device labeled for single use and reported to be reprocessed for use after being opened but not used. Four types of commonly used synthetic absorbable sutures were subjected to 1 and 2 ethylene oxide resterilization cycles. Knot tensile strength was determined for new sutures and for sutures that had been subjected to 1 and 2 ethylene oxide resterilization cycles. As has been found with other types of single-use devices, no general conclusions can be made for absorbable sutures. The strengths of different types of sutures increased, decreased, or stayed the same after repeated sterilization. In addition, the inner packages of some sutures were not intact after reprocessing, possibly exposing the sutures to increased humidity, which can produce degradation leading to loss of strength both immediately and after additional shelf aging and degraded performance after clinical use.
SN - 0899-8205
AD - Division of Mechanics & Materials Science, HFZ-150, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, Rockville, MD 20850, USA
AD - Division of Mechanics & Materials Science, HFZ-150, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, Rockville, MD 20850
U2 - PMID: 11765698.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106932749&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692613
T1 - Growth as a biological marker of inhaled corticosteroid activity.
AU - Malozowski S
AU - Purucker M
Y1 - 2001/11//2001 Nov
N1 - Accession Number: 106692613. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372621.
KW - Administration, Inhalation -- In Infancy and Childhood
KW - Adrenal Cortex Hormones -- Administration and Dosage -- In Infancy and Childhood
KW - Asthma -- Drug Therapy -- In Infancy and Childhood
KW - Biological Markers
KW - Child Development
KW - Adolescence
KW - Adrenal Cortex Hormones -- Adverse Effects
KW - Child
KW - Drug Labeling
KW - Medication Compliance
SP - 796
EP - 802
JO - Current Therapeutic Research
JF - Current Therapeutic Research
JA - CURR THER RES
VL - 62
IS - 11
CY - New York, New York
PB - Elsevier Science
AB - Background: Inhaled corticosteroids (ICSs) are among the standard therapies used to control symptoms of asthma. Current evidence shows that these agents are available systemically and have the capability of negatively affecting growth when administered to children at labeled doses. However, the impact of growth cannot be predicted by most conventional measures of hypothalamic-pituitary-adrenal axis function. Target organs such as bone are likely involved in this effect.Objective: The purpose of this paper was to review the evidence for systemic adverse effects of ICSs in children, particularly with regard to growth.Results: Results of well-designed 1-year studies comparing ICSs with non-ICS standard care have demonstrated that ICSs administered at recommended doses are capable of causing a mean decrease in growth velocity of approximately 1 cm/year (range, 0.5 to 1.8 cm/year) in prepubertal asthmatic children.Conclusions: Children treated with these products should be monitored regularly with stadiometric measurements of growth velocity and titrated individually to the lowest dose that effectively controls their symptoms. It is important for practitioners to recognize the potential systemic impact of these highly effective products in pediatric patients.
SN - 0011-393X
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692614
T1 - Molecular profiling of cancer and drug-induced toxicity using new proteomic technologies.
AU - Ardekani AM
AU - Herman EH
AU - Sistare FD
AU - Liotta LA
AU - Petricoin EF III
Y1 - 2001/11//2001 Nov
N1 - Accession Number: 106692614. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372621.
KW - Biological Markers
KW - Drug Toxicity -- Familial and Genetic
KW - Neoplasms -- Familial and Genetic
KW - Child
KW - Proteins -- Analysis
KW - Mass Spectrometry
SP - 803
EP - 819
JO - Current Therapeutic Research
JF - Current Therapeutic Research
JA - CURR THER RES
VL - 62
IS - 11
CY - New York, New York
PB - Elsevier Science
AB - Background: Completion of the mapping of the human genome has brought the field of research in biological sciences into a new dawn of discovery. Within this postgenomics era in science, proteomic technologies are positioned to play a major role in discovery of new biomarkers for early detection of diseases and drug-induced toxicity, new molecular targets for therapy, and new end points for therapeutic efficacy and toxicity.Objective: Development of patient-specific targeted therapeutics with reduced toxicity and increased efficacy using cells or sera from patients with disease.Methods: New proteomic technologies such as laser capture microscopy are providing rapid, easy access to the purified, diseased human cells from tissue specimens that previously has not been possible. Due to limited availability of patient material, highly sensitive mass spectrometric techniques such as surface-enhanced laser desorption ionization time-of-flight (SELDI-TOF) are used to complement 2-dimensional gel electrophoresis for multiparametric protein characterization.Results: The use of high-throughput SELDI-TOF protein pattern generation techniques should prove valuable for new molecular classification of human tumors, disease stages, and drug-induced toxicity. The use of newly developed high-density protein arrays, antibody arrays, and small molecular arrays in conjunction with laser capture microscopy could have a substantial impact on proteomic profiling of human tumors and human tissues affected in response to drug treatments. SELDI-TOF and laser capture microscopy technologies in conjunction with new bioinformatic software will be powerful tools in the near future for identifying protein fingerprints in cells or sera of patients to predict the outcomes of therapies for any diagnosed disease.Conclusions: The application of all new proteomic technologies should enhance our efforts in designing rational drug therapy strategies that are based on an individual patient's molecular profiling of cellular proteins in the disease state and can identify proteomic fingerprints associated with drug-induced toxicity directly in sera samples. This should provide us with the detailed knowledge necessary to develop novel therapeutics for the treatment of diseases and/or detection of diseases and toxicity at an early stage.
SN - 0011-393X
AD - FDA-NCI Clinical Proteomics Program, Division of Therapeutic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106692614&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692616
T1 - Using identical behavioral tasks in children, monkeys, and rats to study the effects of drugs.
AU - Paule MG
Y1 - 2001/11//2001 Nov
N1 - Accession Number: 106692616. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: NCTR Operant Test Battery (OTB). NLM UID: 0372621.
KW - Child Behavior -- Drug Effects
KW - Drug Evaluation -- In Infancy and Childhood
KW - Animal Studies
KW - Child
KW - Primates
KW - Rats
KW - Research Instruments
SP - 820
EP - 833
JO - Current Therapeutic Research
JF - Current Therapeutic Research
JA - CURR THER RES
VL - 62
IS - 11
CY - New York, New York
PB - Elsevier Science
AB - Background: The need to use animal models to predict the effects of drugs on the nervous system has led to the development of automated systems for the assessment of specific behaviors--identical in both humans and laboratory animals--that represent aspects of specific cognitive processes. At the National Center for Toxicological Research (NCTR), a battery of operant behavioral tasks (the NCTR Operant Test Battery, or OTB) has been developed to model specific behaviors associated with motivation, color and position discrimination, time estimation, short-term memory and attention, and learning.Objectives: The goals of this paper were to describe interspecies similarities in specific behaviors designed to model a variety of cognitive functions and to argue for the use of such behaviors in risk assessments (preclinical studies), monitoring treatment efficacy, and postmarket surveillance.Methods: The literature search was primarily limited to automated systems that are useful in rodents, monkeys, and children.Results: Maintenance of task continuity across species allows for the determination of interspecies similarities in brain function and aids in the extrapolation of data from animals to humans. Comparative data indicate, for example, that the OTB performance of well-trained monkeys is generally indistinguishable from that of children. The demonstration that human OTB performance correlates significantly with intelligence (IQ scores) highlights the relevance of these measures. Results of comparative drug studies indicate that monkeys are good predictors of drug effects in humans. Recent studies have shown that rodent performance in some of these complex tasks is also similar to that of monkeys and children, and that for some drugs, responses are similar to those for monkeys and, presumably, humans.Conclusions: Tools such as the NCTR OTB may provide the opportunity for extensive interspecies comparisons of cognitive processes and provide the means for studying the effects of psychoactive agents by use of relevant end points in a variety of animal models. Such approaches may provide laboratory animal data that could predict adverse drug events in humans, as defined by disturbances in aspects of complex brain function. Likewise, use of similar instruments in the clinic, even in the pediatric setting, could provide longitudinal data--in the same patients--on treatment efficacy and toxicity during clinical trials and postmarket surveillance.
SN - 0011-393X
AD - Head, Behavioral Toxicology Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502; mpaule@nctr.fda.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Scott, Walter Louis
AU - Collier, Paul
T1 - The Vessel Dilator for Central Venous Catheter Placement: Forerunner for Success or Vascular Misadventure?
JO - Journal of Intensive Care Medicine (Wiley-Blackwell)
JF - Journal of Intensive Care Medicine (Wiley-Blackwell)
Y1 - 2001/11//Nov/Dec2001
VL - 16
IS - 6
M3 - Article
SP - 263
EP - 269
SN - 08850666
AB - During placement of a central venous catheter (CVC), the vessel dilator and/or combination dilator/sheath-introducer are recognized as potential causative agents in numerous traumatic complications that may be erroneously ascribed to the catheter, placement needle, or guidewire. A review of the literature and device-user survey are offered in support of the need for additional training in safe dilator use, as well as the need to address device labeling and device design. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Intensive Care Medicine (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAVENOUS catheterization
KW - TRAUMATISM -- Complications
N1 - Accession Number: 5395871; Scott, Walter Louis 1; Collier, Paul 2; Source Information: Nov/Dec2001, Vol. 16 Issue 6, p263; Subject: INTRAVENOUS catheterization; Subject: TRAUMATISM -- Complications; Number of Pages: 7p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1046/j.1525-1489.2001.00263.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106917719
T1 - Clinical practice. Dental device-associated problems: an analysis of FDA postmarket surveillance data.
AU - Fuller J
AU - Parmentier C
Y1 - 2001/11//
N1 - Accession Number: 106917719. Language: English. Entry Date: 20020426. Revision Date: 20150711. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060.
KW - Patient Safety
KW - Dental Equipment -- Adverse Effects
KW - Evaluation Research
KW - Mandatory Reporting
KW - Voluntary Reporting
KW - Descriptive Statistics
KW - Epidemiological Research
KW - United States Food and Drug Administration
KW - United States
KW - Dentists
KW - Databases
KW - Human
SP - 1540
EP - 1548
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 132
IS - 11
CY - Chicago, Illinois
PB - American Dental Association
AB - BACKGROUND: The authors provide an analysis of dental device adverse event reports collected through the U.S. Food and Drug Administration's, or FDA's, mandatory and voluntary reporting programs between Aug. 1, 1996, and June 30, 1999. METHODS: This study includes an analysis of the total number of dental device adverse events reported during the study period and uses descriptive statistics to depict reporters' occupations, types of adverse events (deaths, injuries, malfunctions), device categories, device problems and patient problems. RESULTS: A total of 272,241 device reports were received during the 35-month study period, 28,555 (10.5 percent) of which involved dental devices. Within these reports, two deaths (0.007 percent), 18,406 injuries (64.4 percent) and 9,942 device malfunctions (34.8 percent) were reported. The most commonly reported dental devices were endosseous implants, which represented more than 90 percent of all dental device reports. Most reports (84.1 percent) provided the reporter's occupation, and the most frequently cited occupation was dentist (76.3 percent), followed by dental assistant (4.2 percent). CONCLUSIONS: Dentists and dental staff members are a vital link in the FDA's adverse event reporting system and are encouraged to report device problems to the FDA MedWatch program.
SN - 0002-8177
AD - Director, Regulatory Review Officer, Division of Post-Market Surveillance, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 1350 Piccard Drive, Room 300, HFZ-520, Rockville, MD 20850. E-mail: jyf@cdrh.fda.gov
U2 - PMID: 11806067.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106946565
T1 - Research and professional briefs. Assessing women's perceived benefits, barriers, and stage of change for meeting milk product consumption recommendations.
AU - Gulliver P
AU - Horwath CC
Y1 - 2001/11//2001 Nov
N1 - Accession Number: 106946565. Language: English. Entry Date: 20020809. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Funded by the New Zealand Dairy Board. NLM UID: 7503061.
KW - Women
KW - Attitude to Health
KW - Calcium, Dietary -- Administration and Dosage
KW - Dairy Products
KW - Health Behavior
KW - Behavioral Changes
KW - Questionnaires
KW - Adult
KW - Middle Age
KW - Aged
KW - New Zealand
KW - Factor Analysis
KW - Coefficient Alpha
KW - Descriptive Statistics
KW - Multivariate Analysis of Variance
KW - Female
KW - Survey Research
KW - Milk
KW - Algorithms
KW - Body Weight
KW - Osteoporosis -- Prevention and Control
KW - Funding Source
KW - Human
SP - 1354
EP - 1357
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 101
IS - 11
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Research Fellow, Center for Mental Health Services Department, King's College, London, England
U2 - PMID: 11716318.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106946565&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106935055
T1 - Multiplex PCR for detection of Enterobacteriaceae in blood.
AU - Sen K
AU - Asher DM
Y1 - 2001/11//
N1 - Accession Number: 106935055. Language: English. Entry Date: 20020628. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Polymerase Chain Reaction -- Methods
KW - Blood -- Microbiology
KW - Klebsiella
KW - Serratia
KW - Enterobacteriaceae
KW - Sensitivity and Specificity
KW - Education, Continuing (Credit)
KW - Human
SP - 1356
EP - 1364
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 41
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 11724978.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sen, Keya
AU - Asher, David M.
T1 - Multiplex PCR for detection of Enterobacteriaceae in blood.
JO - Transfusion
JF - Transfusion
Y1 - 2001/11//
VL - 41
IS - 11
M3 - Article
SP - 1356
EP - 1364
SN - 00411132
AB - Describes a multiplex polymerase chain reaction assay that can detect enterobacteriaceae in blood. Four types of bacterial species used in the study; Advantages of 16S rRNA gene to detect bacterial contamination; Potential of the assay to detect very small numbers of bacteria.
KW - POLYMERASE chain reaction
KW - ENTEROBACTERIACEAE
KW - BLOOD collection
N1 - Accession Number: 10918067; Sen, Keya 1; Asher, David M. 1; Source Information: Nov2001, Vol. 41 Issue 11, p1356; Subject: POLYMERASE chain reaction; Subject: ENTEROBACTERIACEAE; Subject: BLOOD collection; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 3 Charts, 10 Graphs; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2002-12151-007
AN - 2002-12151-007
AU - Buck, Jeffrey A.
T1 - Managed mental health care in Medicaid: Does the solution match the problem?
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2001/11//
VL - 29
IS - 2
SP - 177
EP - 180
CY - Germany
PB - Springer
SN - 0894-587X
AD - Buck, Jeffrey A., CMHS/SAMHSA, 5600 Fishers Lane, 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2002-12151-007. PMID: 11939752 Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; Ctr for Mental Health Services, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Release Date: 20020313. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Utilization; Managed Care; Medicaid; Mental Health Services. Minor Descriptor: Drug Abuse. Classification: Health & Mental Health Services (3370). Population: Human (10); Outpatient (60). Location: US. Methodology: Meta Analysis. References Available: Y. Page Count: 4. Issue Publication Date: Nov, 2001.
AB - A recent Inspector General report presented the views of Medicaid officials in seven states with Medicaid managed mental health programs. In all seven states, the officials said that their primary reason for converting to managed mental health care was 'to reduce skyrocketing mental health costs.' This study examined the validity of this claim through a secondary analysis of Medicaid program statistics for mental health and substance abuse treatment services. Results indicate that increases in enrollment and user rates contributed strongly to aggregate expenditure increases. It was therefore concluded that increases in spending due to enrollment increases are outside of the control managed care organizations. Increases resulting from increased access are not, but any restrictions in this area would run counter to other managed care goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - managed mental health care
KW - substance abuse treatment services
KW - Medicaid
KW - enrollment
KW - costs
KW - 2001
KW - Health Care Costs
KW - Health Care Utilization
KW - Managed Care
KW - Medicaid
KW - Mental Health Services
KW - Drug Abuse
KW - 2001
DO - 10.1023/A:1014344832307
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UR - jbuck@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106605524
T1 - The threat is real. Are you prepared for a terrorist attack?
AU - Stopford BM
Y1 - 2001/11/05/2001 Nov 5
N1 - Accession Number: 106605524. Language: English. Entry Date: 20050415. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Nursing; USA. NLM UID: 9892044.
KW - Disaster Planning
KW - Terrorism
SP - 3p
EP - 3p
JO - Nursing Spectrum -- New York & New Jersey Edition
JF - Nursing Spectrum -- New York & New Jersey Edition
JA - NURS SPECTRUM (NY NJ)
VL - 13A
IS - 22
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1081-3101
AD - Clinical Supervisor and Chief Nurse, US Public Health Service, Central US National Medical Response Team: Weapons of Mass Destruction
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thiriet, Nathalie
AU - Jouvert, Peggy
AU - Gobaille, Serge
AU - Solov'Eva, Olga
AU - Gough, Bobby
AU - Aunis, Dominique
AU - Ali, Syed
AU - Zwiller, Jean
T1 - C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain.
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
Y1 - 2001/11/15/
VL - 14
IS - 10
M3 - Article
SP - 1702
EP - 1708
SN - 0953816X
AB - Abstract The neuropeptide C-type natriuretic peptide (CNP) is the primary biologically active natriuretic peptide in brain. Using in situ hybridization, the present report demonstrates that CNP regulates egr-1, c-fos and junB immediate early gene expression in rat brain. In the frontal cortex, CNP induced immediate early gene expression whereas it inhibited dose-dependently the cocaine-induced early gene expression in the dopaminergic projection fields nucleus accumbens and caudate–putamen. CNP may produce its effect directly on dopaminergic neurons because we found that its receptor, guanylyl cyclase GC-B, was expressed in the mesencephalon where dopaminergic neurons originate, as well as in their projection fields. The inhibition by CNP of the early gene expression elicited by cocaine in the caudate–putamen is correlated with a CNP-evoked decrease in cocaine-induced rise in extracellular dopamine, measured by in vivo microdialysis experiments. The significance of the inhibition of cocaine-induced dopamine release and early gene induction by the endogenous peptide CNP is demonstrated by data indicating that CNP reduced the cocaine-induced spontaneous locomotor activation. By inhibiting dopaminergic neuronal activity, CNP represents a potential negative regulator of related behavioural effects of cocaine. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROPEPTIDES
KW - NATRIURESIS
KW - GENE expression
KW - c-fos
KW - egr-1
KW - Extracellular dopamine
KW - guanylyl cyclase
KW - junB
N1 - Accession Number: 5661646; Thiriet, Nathalie 1; Jouvert, Peggy 1; Gobaille, Serge 2; Solov'Eva, Olga 3; Gough, Bobby 4; Aunis, Dominique 1; Ali, Syed 4; Zwiller, Jean 1; Source Information: Nov2001, Vol. 14 Issue 10, p1702; Subject: NEUROPEPTIDES; Subject: NATRIURESIS; Subject: GENE expression; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: egr-1; Author-Supplied Keyword: Extracellular dopamine; Author-Supplied Keyword: guanylyl cyclase; Author-Supplied Keyword: junB; Number of Pages: 7p; Document Type: Article
L3 - 10.1046/j.0953-816X.2001.01791.x
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DP - EBSCOhost
DB - hch
ER -
TY - GEN
ID - 89254884
T1 - Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor.
AU - Peters, G. J.
AU - van Groeningen, C. J.
AU - Giaccone, G.
AU - White Jr, Robert M.
Y1 - 2001/11/15/
N1 - Accession Number: 89254884. Language: English. Entry Date: 20020906. Revision Date: 20161120. Publication Type: commentary. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Fluorouracil -- Pharmacokinetics
KW - Antimetabolites, Antineoplastic -- Pharmacokinetics
KW - Oxidoreductases -- Antagonists and Inhibitors
KW - Oxidoreductases
KW - Chemistry, Pharmaceutical
KW - Prodrugs -- Pharmacodynamics
KW - Time
KW - Pyridines -- Pharmacokinetics
KW - Heterocyclic Compounds -- Pharmacokinetics
KW - Drug Combinations
SP - 4267
EP - 4269
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 19
IS - 22
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - Vrije Universiteit Medical Center, Amsterdam, Netherlands
AD - Food and Drug Administration, Rockville, MD
U2 - PMID: 11709571.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McCormick, Marie C.
AU - Deal, Lisa W.
AU - Devaney, Barbara L.
AU - Chu, Dexter
AU - Moreno, Lorenzo
AU - Raykovich, Karen T.
T1 - The Impact on Clients of a Community-Based Infant Mortality Reduction Program: The National Healthy Start Program Survey of Postpartum Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/12//
VL - 91
IS - 12
M3 - Article
SP - 1975
EP - 1977
PB - American Public Health Association
SN - 00900036
AB - Objectives: This study assessed the effect of the national Healthy Start Program on its clients. Methods: We used a cross-sectional survey of a sample from Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) rosters of women less than 6 months postpartum who were residents of Healthy Start Program areas. Results: Healthy Start clients revealed higher sociodemographic risk, but not behavioral risk, for adverse pregnancy outcome than other area residents. They did not differ from other residents in receipt of services except for a greater likelihood of receiving case management, using birth control at the time of the interview, and rating their prenatal care more highly. Conclusions: The Healthy Start Program succeeded in enrolling women at high risk. It had little effect on the immediately concluded pregnancy, but it might influence future outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Birth control
KW - Health promotion
KW - Infant mortality
KW - Child mortality
KW - Medical care
N1 - Accession Number: 5582731; McCormick, Marie C. 1; Email Address: mmccormi@hsph.harvard.edu; Deal, Lisa W. 1,2; Devaney, Barbara L. 3; Chu, Dexter 3; Moreno, Lorenzo 3; Raykovich, Karen T. 4; Affiliations: 1: Department of Maternal and Child Health, Harvard School of Public Health, Boston, Mass.; 2: David and Lucile Packard Foundation, Los Altos, Calif.; 3: Mathematica Policy Research Inc, Princeton, NJ; 4: Office of Program Evaluation and Legislation, Health Resources and Services Administration, Rockville, Md.; Issue Info: Dec2001, Vol. 91 Issue 12, p1975; Thesaurus Term: Public health; Thesaurus Term: Birth control; Subject Term: Health promotion; Subject Term: Infant mortality; Subject Term: Child mortality; Subject Term: Medical care; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2682
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jason, J.
AU - Archibald, L. K.
AU - Nwanyanwu, O. C.
AU - Bell, M.
AU - Jensen, R. J.
AU - Gunter, E.
AU - Buchanan, I.
AU - Larned, J.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Jarvis, W. R.
T1 - The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2001/12//
VL - 126
IS - 3
M3 - Article
SP - 466
EP - 473
SN - 00099104
AB - Worldwide, over 40% of children have iron deficiency anaemia, frequently associated with infections. Certain cytokines are involved in both immune activation/response to infection and iron transport/metabolism. We therefore assessed the relations among iron deficiency, cytokine production and lymphocyte activation markers in 142 hospitalized Malawian children. We examined peripheral blood lymphocyte antigens/cytokine production using four- colour flow cytometry and serum transferrin receptor (TfR) levels, an inverse measure of iron status unaffected by acute illness or infection, with an enzyme-linked immunosorbent assay. Wilcoxon rank sum tests and logistic regression analyses (LRA) were performed. Iron deficiency (TfR ≥ 10 μg/ml) versus TfR < 10 μg/ml, was associated with higher percentages of lymphocytes producing: (a) induced or spontaneous IL-6 (medians: induced, 15·9% for iron-deficient children versus 8·8% for iron-replete children, P = 0·002; spontaneous, 24·4% versus 13·0%, P < 0·001) and (b) induced IFN-γ (medians:18·4% versus 12·4%, P = 0·006). The percentages of CD8+ T cells spontaneously producing IL-6 and of all lymphocytes producing induced TNF-α and IFN-γ in the same cell had the strongest relationships to iron deficiency (b = + 0·0211, P = 0·005 and b = + 0·1158, P = 0·012, respectively, LRA) and were also positively related to the co-expression of the T cell activation markers HLA DR and CD38. Severe iron deficiency (TfR ≥ 30 μg/ml) was associated with the percentage of lymphocytes producing induced IL-4 (medians: 0·5% versus 1·6%, P < 0·010). The cytokine patterns associated with iron deficiency in our study would preserve iron stores but also preferentially retain the activation capabilities of T cells, albeit not necessarily other immune cells, until a critical level of iron depletion is reached. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - IRON
KW - LYMPHOCYTE transformation
KW - CYTOKINES
KW - HEALTH
KW - IMMUNOLOGY
KW - MALAWI
KW - cytokines
KW - IL-4
KW - IL-6
KW - iron deficiency
KW - lymphocyte activation
KW - transferrin receptor
N1 - Accession Number: 5569666; Jason, J. 1; Archibald, L. K. 2; Nwanyanwu, O. C. 3; Bell, M. 2; Jensen, R. J. 4; Gunter, E. 4; Buchanan, I. 1; Larned, J. 1; Kazembe, P. N. 5; Dobbie, H. 5; Jarvis, W. R. 2; Source Information: Dec2001, Vol. 126 Issue 3, p466; Subject: CHILDREN -- Health; Subject: IRON; Subject: LYMPHOCYTE transformation; Subject: CYTOKINES; Subject: HEALTH; Subject: IMMUNOLOGY; Geographic Terms: MALAWI; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: IL-4; Author-Supplied Keyword: IL-6; Author-Supplied Keyword: iron deficiency; Author-Supplied Keyword: lymphocyte activation; Author-Supplied Keyword: transferrin receptor; Number of Pages: 8p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2249.2001.01707.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106943443
T1 - Non-fatal animal related injuries to youth occurring on farms in the United States, 1998.
AU - Hendricks KJ
AU - Adekoya N
Y1 - 2001/12//
N1 - Accession Number: 106943443. Language: English. Entry Date: 20020726. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Accidents, Occupational -- Epidemiology -- In Adolescence
KW - Accidents, Home -- Epidemiology -- In Adolescence
KW - Agriculture -- In Adolescence -- United States
KW - Animals -- In Adolescence -- United States
KW - United States
KW - Adolescence
KW - Adolescent Health
KW - Child
KW - Descriptive Statistics
KW - Male
KW - Female
KW - Horses
KW - Cattle
KW - Adult
KW - Confidence Intervals
KW - Injury Pattern
KW - Interviews
KW - Stratified Random Sample
KW - Human
SP - 307
EP - 311
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
PB - BMJ Publishing Group
AB - OBJECTIVE: To provide data on the magnitude and patterns of animal related on-farm injuries to youth in the United States. DATA SOURCE: A survey of 26,000 farm households conducted for the National Institute for Occupational Safety and Health by the United States Department of Agriculture in 1998. SUBJECTS: Youth younger than 20 years of age. RESULTS: There were an estimated 6,438 animal related on-farm injuries to youth in 1998. 70% occurred to farm residents; 69% were work related. Males accounted for 64% and approximately 41% occurred to those younger than 10; 37% involved horses and 31% cattle. Most horse related injuries occurred to females and a majority of the cattle related injuries were to males. Additionally, most of the cattle related injuries were work related, while horse related injuries were mainly nonwork. CONCLUSIONS: One out of every five youth injuries occurring on farms in the United States is animal related. These animal related injuries were due to both work and non-work related exposures. The large number of horse and cattle related injuries highlights a need for intervention strategies based on the injury circumstances common to these animals.
SN - 1353-8047
AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 1808, Morgantown, WV 26505; khendricks@cdc.gov
U2 - PMID: 11770657.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106948441
T1 - Factors associated with use of preventive dental and health services among U.S. adolescents.
AU - Yu SM
AU - Bellamy HA
AU - Schwalberg RH
AU - Drum MA
Y1 - 2001/12//2001 Dec
N1 - Accession Number: 106948441. Language: English. Entry Date: 20020816. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 9102136.
KW - Dental Health Services -- Utilization -- In Adolescence
KW - Preventive Health Care -- Utilization -- In Adolescence
KW - Adolescent Health Services -- Utilization
KW - Adolescence
KW - Child
KW - Adult
KW - Prospective Studies
KW - Female
KW - Male
KW - Sex Factors
KW - Middle Age
KW - Parents
KW - Educational Status
KW - Income
KW - Health Services Accessibility -- In Adolescence
KW - Ethnic Groups
KW - Insurance, Health
KW - Socioeconomic Factors
KW - United States
KW - Self Report
KW - Cluster Sample
KW - Interviews
KW - Questionnaires
KW - Regression
KW - Odds Ratio
KW - Confidence Intervals
KW - Human
SP - 395
EP - 405
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
JA - J ADOLESC HEALTH
VL - 29
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: To examine adolescents' use of preventive medical and dental services and its relationship to demographic characteristics and other variables reflecting access to and need for care. METHODS: Self- and parent-reported data from a sample of 5644 adolescents aged 11 to 21 years from the National Longitudinal Study of Adolescent Health (Add Health). Variables studied include the influence of both the adolescents' demographic and socioeconomic characteristics (age, race/ethnicity, place of birth, acculturation, insurance status, and perception of health), as well as those of their parents (race/ethnicity, income, level of education, place of birth) on their lifetime use and use within the past year of medical and dental services. Bivariate and logistic regression analyses were conducted using SAS and SUDAAN. RESULTS: Approximately 32% of respondents had not had a physical examination in the year before the survey, and the same percentage had not had a dental examination. Approximately 2% reported never having had either a physical or a dental examination. Logistic regression reveals that lack of insurance, low family income, and low parental education level are significantly associated with the lack of preventive medical care. Lack of an annual dental visit was associated with male gender; black, Hispanic, or mixed race/ethnicity; and lack of insurance. Never having had a dental visit was the only dependent variable found to be associated with place of birth. CONCLUSIONS: Health insurance and family income are most consistently related to adolescents' use of preventive medical and dental care. However, the relationship between lack of dental care and place of birth emphasizes the need to improve access to dental services for immigrant teens. These findings are particularly relevant as states design systems of care for adolescents under the State Children's Health Insurance Program.
SN - 1054-139X
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18A-55, Rockville, MD 20857
U2 - PMID: 11728889.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Precision Grip Force Control of Older and Younger Adults, Revisited.
AU - Lowe, Brian D.
JO - Journal of Occupational Rehabilitation
JF - Journal of Occupational Rehabilitation
Y1 - 2001/12//
VL - 11
IS - 4
SP - 267
EP - 279
SN - 10530487
N1 - Accession Number: 15605284; Author: Lowe, Brian D.: 1 email: blowe@cdc.gov. ; Author Affiliation: 1 National Institute for Occupational Safety and Health, Cincinnati, Ohio; No. of Pages: 13; Language: English; Publication Type: Article; Update Code: 20050111
N2 - This study revisited the hypothesis that older adults lose some ability to efficiently control precision grip force. A previous study demonstrated such a decrement in older adults' performance in a vertical lift and support maneuver. This study employed a similar paradigm in which dynamic forces were applied with a simulated hand tool while measuring grip force and force applied with the tool. Measures of grip force control reflected subjects' modulation of grip force in parallel with force transmitted with the tool and their scaling of the ratio of grip to applied force. Nine older (>65 years) and 9 younger (<65 years) subjects' grip force control measures were compared with emphasis on recruiting active older individuals for whom upper extremity usage was high in their daily life. No statistically significant age effects were found in either force control measure, suggesting a smaller age-related decrement than reported in a previous study. ABSTRACT FROM AUTHOR
KW - *GRIP strength
KW - *MUSCLE strength
KW - TOOLS
KW - FORCE & energy
KW - WORK
KW - coordination
KW - force control
KW - precision grip
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106925374
T1 - Precision grip force control of older and younger adults, revisited.
AU - Lowe BD
Y1 - 2001/12//
N1 - Accession Number: 106925374. Language: English. Entry Date: 20020524. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Grant Information: National Institute on Aging training grant (Grant #22314815A). NLM UID: 9202814.
KW - Grip Strength
KW - Fingers
KW - Grip Strength -- Evaluation
KW - Age Factors
KW - Comparative Studies
KW - Regression
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Male
KW - Funding Source
KW - Human
SP - 267
EP - 279
JO - Journal of Occupational Rehabilitation
JF - Journal of Occupational Rehabilitation
JA - J OCCUP REHABIL
VL - 11
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - This study revisited the hypothesis that older adults lose some ability to efficiently control precision grip force. A previous study demonstrated such a decrement in older adults' performance in a vertical lift and support maneuver. This study employed a similar paradigm in which dynamic forces were applied with a simulated hand tool while measuring grip force and force applied with the tool. Measures of grip force control reflected subjects' modulation of grip force in parallel with force transmitted with the tool and their scaling of the ratio of grip to applied force. Nine older (> 65 years) and 9 younger (< 65 years) subjects' grip force control measures were compared with emphasis on recruiting active older individuals for whom upper extremity usage was high in their daily life. No statistically significant age effects were found in either force control measure, suggesting a smaller age-related decrement than reported in a previous study.
SN - 1053-0487
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226. E-mail: blowe@cdc.gov
U2 - PMID: 11826727.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106895909
T1 - Device safety. Using denture cleansers safely.
AU - Fuller J
Y1 - 2001/12//
N1 - Accession Number: 106895909. Language: English. Entry Date: 20020201. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Dentifrices -- Poisoning
KW - Dentures
KW - Patient Education
SP - 22
EP - 22
JO - Nursing
JF - Nursing
JA - NURSING
VL - 31
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Director, Regulatory Review Office, Center for Devices and Radiological Health Food and Drug Administration, Rockville, Md
U2 - PMID: 11921710.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Caron, A.
AU - Mayer, J.-C.
AU - Menu, P.
AU - Alayash, A.
AU - Marie, P.-Y.
AU - Vigneron, C.
T1 - Measurement of blood volume after haemodilution with haemoglobin-based oxygen carriers by a radiolabelled-albumin method.
JO - Transfusion Medicine
JF - Transfusion Medicine
Y1 - 2001/12//
VL - 11
IS - 6
M3 - Article
SP - 433
EP - 442
SN - 09587578
AB - . Recent studies have shown that the use of haemoglobin-based oxygen-carrying solutions (HBOCs) for perioperative haemodilution could significantly reduce the need for packed red blood cells in clinical practice. Though the effects of HBOCs on plasma volume have been characterized in experimental models of volume resuscitation from hypovolaemic shock, little is known about their action in normovolaemic haemodilution conditions. We therefore applied a radiolabelled serumalbumin method to determine blood volume after haemodilution with crosslinked or conjugated haemoglobin, in comparison with a reference solution of hydroxyethyl starch (HES). Three groups of New Zealand white rabbits were studied (n = 7 each group) subjected to moderate exchange transfusion with low molecular weight HES, bis(3,5-dibromosalicyl)fumarate crosslinked haemoglobin (αα-Hb), or dextran-conjugated haemoglobin (Hb-Dex-BTC). HES induced no changes in heart rate and blood pressure. The amplitude and duration of blood pressure increase and bradycardia were similar in both haemoglobin groups. A significant contraction of blood volume (12%) was observed 60 min after haemodilution with αα-Hb, compared to HES and Hb-Dex-BTC. At the same time point, a decrease in absolute haemoglobin (plasma haemoglobin × plasma volume) was also noted. This study suggests that in haemodilution conditions, the specific oncotic properties and circulating persistence of crosslinked and conjugated haemoglobin solutions affect the pattern of blood volume distribution differently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODILUTION
KW - BLOOD volume
KW - HEMOGLOBIN
KW - blood substitute
KW - blood volume
KW - Haemodilution
KW - haemoglobin-based oxygen carriers
N1 - Accession Number: 5721347; Caron, A. 1; Mayer, J.-C. 2; Menu, P. 1; Alayash, A. 3; Marie, P.-Y. 2; Vigneron, C. 1,4; Source Information: Dec2001, Vol. 11 Issue 6, p433; Subject: HEMODILUTION; Subject: BLOOD volume; Subject: HEMOGLOBIN; Author-Supplied Keyword: blood substitute; Author-Supplied Keyword: blood volume; Author-Supplied Keyword: Haemodilution; Author-Supplied Keyword: haemoglobin-based oxygen carriers; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1046/j.1365-3148.2001.00337.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2002-13822-010
AN - 2002-13822-010
AU - Holmstedt-Mark, Barbara J.
AU - Smolinsky, Frank T.
AU - Bradshaw, Dana
T1 - The psychosocial aspect of the anthrax vaccine: 'The Dover experience.'
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2001/12//
VL - 166
IS - 12,Suppl 2
SP - 36
EP - 40
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Holmstedt-Mark, Barbara J., Dover Air Force Base, 436th Public Affairs, DE, US, 19902
N1 - Accession Number: 2002-13822-010. Partial author list: First Author & Affiliation: Holmstedt-Mark, Barbara J.; Dover Air Force Base, 436th ADOS, Dover Air Force Base, DE, US. Release Date: 20020807. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Operational Impact of Psychological Casualties from Weapons of Mass Destruction (WMD), Jul, 2000, Uniformed Services U of Health Sciences, Armed Forces Radiobiology Research Inst, Bethesda, MD, US. Major Descriptor: Drug Therapy; Immunization; Military Personnel; Side Effects (Treatment); Treatment Refusal. Minor Descriptor: Gossip; Health Care Services; Mass Media; Medical Personnel; Therapeutic Processes; Trust (Social Behavior). Classification: Health & Mental Health Services (3370); Military Psychology (3800). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 5. Issue Publication Date: Dec, 2001.
AB - This paper focuses on the Department of Defense (DoD) Anthrax Vaccination Implementation Program (AVIP) at Dover Air Force Base. The authors relate the effects of an organized 'anthrax-no' group in using the Internet and the media to launch an intense rumor campaign against the DoD AVIP, which led to mistrust of and lack of confidence in senior leaders and the medical community. For many Airmen, the fear of the vaccine took precedent over the threat of the disease. The paper gives the history of the Dover AVIP, how the media campaign and rumor mill began running high against the anthrax vaccine, the role of the Vaccine Adverse Event Reporting System, the development of trust problems between the flying and medical communities, how military personnel began to combat the rumors, and lessons learned. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - anthrax vaccine
KW - media
KW - rumors
KW - Department of Defense
KW - military personnel
KW - medical community
KW - Dover Air Force Base
KW - trust
KW - medical program
KW - anthrax-no campaign
KW - 2001
KW - Drug Therapy
KW - Immunization
KW - Military Personnel
KW - Side Effects (Treatment)
KW - Treatment Refusal
KW - Gossip
KW - Health Care Services
KW - Mass Media
KW - Medical Personnel
KW - Therapeutic Processes
KW - Trust (Social Behavior)
KW - 2001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-13822-010&site=ehost-live&scope=site
UR - barbara.holmstedt-mark@dover.af.mil
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-03296-003
AN - 2003-03296-003
AU - Evelyn, B.
AU - Toigo, T.
AU - Banks, D.
AU - Pohl, D.
AU - Gray, K.
AU - Robins, B.
AU - Ernat, J.
T1 - Participation of Racial/Ethnic Groups in Clinical Trials and Race-Related Labeling: A Review of New Molecular Entities Approved 1995-1999.
JF - Journal of the National Medical Association
JO - Journal of the National Medical Association
JA - J Natl Med Assoc
Y1 - 2001/12//
VL - 93
IS - 12
SP - 18S
EP - 24S
CY - US
PB - National Medical Assn
SN - 0027-9684
SN - 1943-4693
AD - Evelyn, B., U.S. Food and Drug Administration, Rockville, MD, US, 20857
N1 - Accession Number: 2003-03296-003. PMID: 11798060 Partial author list: First Author & Affiliation: Evelyn, B.; Office of Special Health Issues, Office of the Commissioner, U.S. Food and Drug Administration, Rockville, MD, US. Other Publishers: Elsevier Science. Release Date: 20040217. Correction Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Subjects; Experimentation; Participation; Racial and Ethnic Groups; Racial and Ethnic Differences. Minor Descriptor: Blacks; Latinos/Latinas. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Location: US. Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2001.
AB - This study reviews racial and ethnic group participation in clinical trials and race-related labeling for new molecular entities approved during a 5-yr. period by the Food and Drug Administration (FDA). This was a retrospective review of FDA medical officers' reviews of clinical trial protocols and product labeling for 185 new molecular entities (NME's). Enrollment data were obtained from the reviews and tabulated according to race/ethnicity. This study quantifies the participation of racial/ethnic groups in clinical trials by year and therapeutic category, and also categorizes labeling based on race/ethnicity effects. African Americans participated in trials to the greatest extent, but their participation steadily declined from 12% in 1995 to 6% in 1999. In all cases, Hispanic participants appear to be far below their representation in the population. Some differences for all racial and ethnic groups are seen when comparisons from year-to-year or among drug classes are made. Labeling for 45% of the products contained some statement about race, although in only 8% were differences related to race described. Fifty percent (50%) of the effects were pharmacokinetic, 39% were efficacy, and 11% were safety. One product label recommended a change in dosage based on racial differences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical trial participation
KW - race-related labeling
KW - product labeling
KW - racial group participation
KW - ethnic group participation
KW - clincal protocols
KW - African Americans participation
KW - Hispanic participants
KW - 2001
KW - Experimental Subjects
KW - Experimentation
KW - Participation
KW - Racial and Ethnic Groups
KW - Racial and Ethnic Differences
KW - Blacks
KW - Latinos/Latinas
KW - 2001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-03296-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2001-09685-001
AN - 2001-09685-001
AU - Zhan, Chunliu
AU - Sangl, Judith
AU - Bierman, Arlene S.
AU - Miller, Marlene R.
AU - Friedman, Bruce
AU - Wickizer, Steve W.
AU - Meyer, Gregg S.
T1 - Potentially inappropriate medication use in the community-dwelling elderly: Findings from the 1996 Medical Expenditure Panel Survey.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2001/12//
VL - 286
IS - 22
SP - 2823
EP - 2829
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
AD - Zhan, Chunliu, Agency for Healthcare Research & Quality, Ctr for Quality Improvement & Patient Safety, 6011 Executive Blvd, Ste 200, Rockville, MD, US, 20852
N1 - Accession Number: 2001-09685-001. PMID: 11735757 Partial author list: First Author & Affiliation: Zhan, Chunliu; Agency for Healthcare Research & Quality, Rockville, MD, US. Release Date: 20011219. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Gerontological Society of America Annual Meeting, Nov, 2000, Washington, DC, US. Conference Note: This work was presented in part at the aforementioned conference. Major Descriptor: Drug Usage; Drugs; Risk Factors; Taxonomies; Trends. Minor Descriptor: Geriatrics. Classification: Gerontology (2860); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2001.
AB - Reports latest estimates from the 1996 Medical Expenditure Panel Survey of potentially inappropriate medication use among the community-dwelling elderly population. The sample included 2,455 Ss aged 65 years or older, representing 32,294,810 elderly US patients. The 1997 Beers criteria (M. H. Beers, 1997) were the basis for this analysis. Because of controversy surrounding the Beers criteria (J. Gurwitz, 1994), the authors convened an expert panel to identify a subset of these drugs that should be avoided, as well as to identify any clinical indications for use of the listed drugs as of 1996. In 1996, approximately 6.9 million community-dwelling elderly Ss (21.3%) received at least 1 of the 33 potentially inappropriate medications listed in the 1997 Beers criteria. Even if one uses the conservative expert panel categorization and evaluates the 11 drugs that should always be avoided by elderly patients, almost 1 million elderly Ss (2.6%) received at least 1 inappropriate medication. Some inappropriate medication use decreased from 1987-96, consistent with findings of A. Blazer et al (2000). Elderly patients are more likely to be in poor health than the general population and use more medications, both factors associated with increased risk of inappropriate medication use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence of potentially inappropriate medication use
KW - criteria
KW - risk factors
KW - trends
KW - community dwelling elderly
KW - 2001
KW - Drug Usage
KW - Drugs
KW - Risk Factors
KW - Taxonomies
KW - Trends
KW - Geriatrics
KW - 2001
DO - 10.1001/jama.286.22.2823
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2001-09685-001&site=ehost-live&scope=site
UR - czhan@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Harlan Jr., William R.
T1 - Editorial.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Editorial
SP - 1
EP - 4
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - Editorial. Focuses on the developments in alternative medicine from Korea and the United States. Information on acupuncture; Efforts to address the practice of traditional and Western approaches to medical practice; Popularity of evidence-based medicine as a result of the public interest in complementary and alternative medicine.
KW - ALTERNATIVE medicine
KW - MEDICINE -- Practice
KW - ACUPUNCTURE
KW - EVIDENCE-based medicine
N1 - Accession Number: 5921195; Harlan Jr., William R. 1; Source Information: Dec2001 Supplement 1, Vol. 7 Issue 6, p1; Subject: ALTERNATIVE medicine; Subject: MEDICINE -- Practice; Subject: ACUPUNCTURE; Subject: EVIDENCE-based medicine; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1089/107555301753393715
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5921195&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Harlan Jr., William R.
T1 - Research on Complementary and Alternative Medicine Using Randomized Controlled Trials.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Article
SP - 45
EP - 52
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - In 1998, the National Institutes of Health (NIH) formed the National Center for Complementary and Alternative Medicine (NCCAM) from what had formerly been the Office of Alternative Medicine. This presentation opens with a brief discussion on the history of the NIH and the development of CAM at the NIH before moving on to the work of the NCCAM. The NCCAM is moving toward an integration of CAM therapies into conventional medicine, when there is evidence for the value of CAM. One of twenty-five institutes or centers at the NIH, the NCCAM looks at evidence-based medicine and public health. In this context, "public health" means educating the public about its health. The NCCAM supports training to conduct research and plays an important role in disseminating information to the public and to health providers about what works and what is safe. This evolves into the concept of evidence-based medical and public-health practices, that is, making decisions on the basis of evidence from scientifically rigorous studies that are sufficiently large to provide a confident estimate of biologically and medically important benefits and risks. In the hierarchy of generating scientific evidence, randomized controlled trials are considered the "gold standard." The NCCAM entertains proposals for studies that come spontaneously from investigators, or, upon identifying an existing need that is not being met by the investigative community, the NCCAM can initiate a request for proposals. Every proposal is subjected to a rigorous application and review process. Another possible step in the assessment of the evidence from clinical trials is to do a systematic analysis of several studies to bring together all the information that is available. Systematic reviews of smaller studies that individually might have an insufficient sample size can assist in making treatment decisions, but, importantly, they can lead the NCCAM in the development of future, definitive studies. Training to conduct research is especially important to CAM. This presentation outlines several approaches the NCCAM has to training (see http://nccam.nih.gov). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Alternative & Complementary Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - CLINICAL trials
KW - PUBLIC health administration
N1 - Accession Number: 5921205; Harlan Jr., William R. 1; Source Information: Dec2001 Supplement 1, Vol. 7 Issue 6, p45; Subject: ALTERNATIVE medicine; Subject: CLINICAL trials; Subject: PUBLIC health administration; Number of Pages: 8p; Document Type: Article
L3 - 10.1089/107555301753393805
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5921205&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Harlan Jr., William R.
T1 - New Opportunities and Proven Approaches in Complementary and Alternative Medicine Research at the National Institutes of Health.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Article
SP - 53
EP - 59
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - This presentation describes some of the issues that arise when applying the clinical-trial approach of conventional medicine to complementary and alternative medicine (CAM) modalities. Conventional medicine has been making the evolution to using an evidence base and to making recommendations only when the evidence is strong. The National Center for Complementary Medicine (NCCAM), one of twenty-five Institutes or Centers of the National Institutes of Health (NIH), is working to hold CAM to the same high standards, not by rejecting previous CAM research, but by building on that strong evidence base of what works and what is safe. The process for conventional drug and device development follows an orderly process of preclinical studies (usually on animals), phase I, phase II, and phase III studies (with the large human clinical trial phase taking place in phase III). Today, the randomized controlled trial is recognized as providing the highest level of scientific evidence. This conventional medicine approach to development is now being used to develop complementary and alternative therapies. For instance, the discovery and development of Taxol (Bristol-Meyers Squibb, New York, NY), an extract from the bark of the Pacific yew tree that is now a widely used chemotherapeutic agent, followed the conventional pathway to approval and marketing. But for most CAM products, the pathway is not so straightforward. Most CAM therapies are traditional therapies or new products that are already available to the public. Most of what is known about these therapies is of an anecdotal nature. There has been little isolation of the active principals from the crude product and there has usually been no preclinical testing. This presentation details various approaches and programs that address how to plan and conduct a rigorous clinical trial of a CAM product. And, while it takes a good deal of persistence and a strong focus on what are the critical principals in a trial, I conclude that it is possible to apply randomized controlled trials to most of the CAM modalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Alternative & Complementary Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - CLINICAL trials
KW - DRUG development
N1 - Accession Number: 5921204; Harlan Jr., William R. 1; Source Information: Dec2001 Supplement 1, Vol. 7 Issue 6, p53; Subject: ALTERNATIVE medicine; Subject: CLINICAL trials; Subject: DRUG development; Number of Pages: 7p; Document Type: Article
L3 - 10.1089/107555301753393814
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=5921204&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106985038
T1 - Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey.
AU - Zhan C
AU - Sangl J
AU - Bierman AS
AU - Miller MR
AU - Friedman B
AU - Wickizer SW
AU - Meyer GS
AU - Zhan, C
AU - Sangl, J
AU - Bierman, A S
AU - Miller, M R
AU - Friedman, B
AU - Wickizer, S W
AU - Meyer, G S
Y1 - 2001/12/12/
N1 - Accession Number: 106985038. Language: English. Entry Date: 20021206. Revision Date: 20161112. Publication Type: journal article; CEU; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Drug Utilization -- In Old Age
KW - Drugs, Prescription -- Contraindications -- In Old Age
KW - Drug Utilization -- Trends
KW - Drugs, Prescription -- Adverse Effects
KW - Geriatrics
KW - Confidence Intervals
KW - Expert Clinicians
KW - Aged
KW - Aged, 80 and Over
KW - Community Living -- In Old Age
KW - Surveys
KW - United States
KW - Interviews
KW - Analysis of Variance
KW - Logistic Regression
KW - Education, Continuing (Credit)
KW - Human
SP - 2823
EP - 2884
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 286
IS - 22
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Inappropriate medication use is a major patient safety concern, especially for the elderly population. Using explicit criteria, prior studies have found that 23.5% and 17.5% of the US community-dwelling elderly population used at least 1 of 20 potentially inappropriate medications in 1987 and 1992, respectively.Objectives: To determine the prevalence of potentially inappropriate medication use in community-dwelling elderly persons in 1996, to assess trends over 10 years, categorize inappropriate medication use according to explicit criteria, and to examine risk factors for inappropriate medication use.Design, Setting, and Participants: Respondents aged 65 years or older (n = 2455) to the 1996 Medical Expenditure Panel Survey, a nationally representative survey of the US noninstitutionalized population were included. A 7-member expert panel was convened to categorize inappropriate medications.Main Outcome Measure: Prevalence of use of 33 potentially inappropriate medications.Results: In 1996, 21.3% (95% confidence interval [CI], 19.5%-23.1%) of community-dwelling elderly patients in the United States received at least 1 of 33 potentially inappropriate medications. Using the expert panel's classifications, about 2.6% of elderly patients (95% CI, 2.0%-3.2%) used at least 1 of the 11 medications that should always be avoided by elderly patients; 9.1% (95% CI, 7.9%-10.3%) used at least 1 of the 8 that would rarely be appropriate; and 13.3% (95% CI, 11.7%-14.9%) used at least 1 of the 14 medications that have some indications but are often misused. Use of some inappropriate medications declined between 1987 and 1996. Persons with poor health and more prescriptions had a significantly higher risk of inappropriate medication use.Conclusions: Overall inappropriate medication use in elderly patients remains a serious problem. Despite challenges in using explicit criteria for assessing inappropriate medications for elderly patients, such criteria can be applied to population-based surveys to identify opportunities to improve quality of care and patient safety. Enhancements of existing data sources to include dosage, duration, and indication may augment national improvement and monitoring efforts.
SN - 0098-7484
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 6011 Executive Blvd, Suite 200, Rockville, MD 20852, USA
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 6011 Executive Blvd, Suite 200, Rockville, MD 20852; czhan@ahrq.gov
U2 - PMID: 11735757.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106985038&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106888655
T1 - Ergonomic job design to accommodate and prevent musculoskeletal disabilities.
AU - Waters TR
AU - MacDonald LA
Y1 - 2001/12/31/
N1 - Accession Number: 106888655. Language: English. Entry Date: 20031128. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8917250.
KW - Cumulative Trauma Disorders -- Prevention and Control
KW - Ergonomics
KW - Musculoskeletal Diseases -- Prevention and Control
KW - Occupational Diseases -- Prevention and Control
SP - 88
EP - 93
JO - Assistive Technology
JF - Assistive Technology
JA - ASSIST TECHNOL
VL - 13
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Work-related musculoskeletal disorders (MSDs) account for a major portion of the cost of work-related injury and illness in the United States. Many of these injuries and illnesses lead to temporary or permanent disability. It is generally accepted that the incidence of MSDs increases when the demands of the job exceed the capabilities of the worker. As the workforce ages and physical capabilities decline, it is anticipated that many more Americans will request disability-related leave resulting from musculoskeletal disorders because they are unable to meet the demands of the job. To prevent these disabilities and to accommodate a wider range of people in the workforce, physical job demands may have to be reduced so that a larger portion of the population will be capable of working. Providing engineering controls or alternative work arrangements allows for accommodation of workers with a wide range of capabilities and can assist in rehabilitation and early return to work following injury.
SN - 1040-0435
AD - Chief, Human Factors and Ergonomics Research Section, National Institute for Occupational Safety and Health, 4676 Columbia Parkway (MS C-24), Cincinnati, OH 45226
U2 - PMID: 12530836.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106888655&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106982168
T1 - Identification of children with special health care needs: a cornerstone to achieving Healthy People 2010.
AU - McPherson M
AU - Honberg L
Y1 - 2002/01//2002 Jan-Feb
N1 - Accession Number: 106982168. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Healthy People 2010
KW - Special Populations
KW - Child, Disabled
KW - Health Services Needs and Demand
KW - Community Health Services
SP - 22
EP - 23
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 2
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1530-1567
AD - Division of Services for Children With Special Health Needs, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md
U2 - PMID: 11888433.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106982168&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106541876
T1 - Effectiveness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamide in an i.v. admixture area.
AU - Connor TH
AU - Anderson RW
AU - Sessink PJ
AU - Spivey SM
Y1 - 2002/01//1/1/2002
N1 - Accession Number: 106541876. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part, Carmel Pharma, Inc., Shelton, CT. NLM UID: 9503023.
KW - Occupational Exposure -- Prevention and Control
KW - Cyclophosphamide
KW - Ifosfamide
KW - Drug Compounding -- Equipment and Supplies
KW - Occupational Health
KW - Occupational Safety
KW - Infusions, Intravenous
KW - Southwestern United States
KW - Ambulatory Care
KW - Cancer Care Facilities
KW - Pharmacy Service
KW - Pharmacy Technicians -- Education
KW - Comparative Studies
KW - Prospective Studies
KW - Pretest-Posttest Design
KW - Chromatography, High Pressure Liquid
KW - Descriptive Statistics
KW - Funding Source
KW - Human
SP - 68
EP - 72
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 59
IS - 1
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Senior Service Fellow, Robert A Taft Laboratories, National Institute for Occupational Safety and Health (MS-C23), 4676 Columbia Parkway, Cincinnati, OH 45226; twc6@cdc.gov
U2 - PMID: 11813470.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106541876&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106910309
T1 - Risk factors for Helicobacter pylori resistance in the United States: the Surveillance of H. pylori Antimicrobial Resistance Partnership (SHARP) Study, 1993-1999.
AU - Meyer JM
AU - Silliman NP
AU - Wang W
AU - Siepman NY
AU - Sugg JE
AU - Morris D
AU - Zhang J
AU - Bhattacharyya H
AU - King EC
AU - Hopkins RJ
Y1 - 2002/01//1/1/2002
N1 - Accession Number: 106910309. Language: English. Entry Date: 20020322. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Drug Resistance, Microbial
KW - Helicobacter Infections -- Microbiology
KW - Helicobacter Pylori -- Drug Effects
KW - Risk Factors
KW - Patient Education
KW - Meta Analysis
KW - Confidence Intervals
KW - Odds Ratio
KW - Univariate Statistics
KW - Data Analysis Software
KW - Human
SP - 13
EP - I39
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 136
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 0003-4819
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Division of Pharmaceutical Evaluation III (HFD-880), 9201 Corporate Blvd, Room S-402, Rockville, MD 20850
U2 - PMID: 11777360.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106910309&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106932783
T1 - Effects of different disinfection and sterilization methods on tensile strength of materials used for single-use devices.
AU - Brown SA
AU - Merritt K
AU - Woods TO
AU - McNamee SG
AU - Hitchins VM
AU - Brown, Stanley A
AU - Merritt, Katharine
AU - Woods, Terry O
AU - McNamee, Scott G
AU - Hitchins, Victoria M
Y1 - 2002/01//2002 Jan-Feb
N1 - Accession Number: 106932783. Language: English. Entry Date: 20020621. Revision Date: 20161117. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Tensile Strength
KW - Disposable Equipment
KW - Sterilization and Disinfection
KW - Chlorine
KW - Ethylene Oxide
KW - Comparative Studies
KW - Human
SP - 23
EP - 27
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 36
IS - 1
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - Driven by economic and time constraints, some medical centers and third parties are resterilizing single-use devices (SUDs) for reuse. The steam autoclave is quick, but most plastics used in SUDs cannot survive the temperature. Thus, a number of new methods of cleaning, disinfecting, and sterilizing these complex devices are being introduced on the market. The present study investigated the effects of a range of methods on the tensile strength of latex rubber, silicone elastomer, 2 different formulations of polyurethane, nylon, and high-density polyethylene (HDPE) specimens. The methods used were sodium hypochlorite bleach (Clorox), peracetic acid + hydrogen peroxide (Steris), formaldehyde gas (Chemiclave), low-temperature peracetic acid and gas plasma (Plazlyte), and low-temperature hydrogen peroxide gas plasma (Sterrad). The results showed that silicone elastomer was minimally affected, whereas the strengths of nylon, polyethylene, and latex were reduced by some of the methods. Depending on the formulation, the strength of polyurethane either increased or decreased. The data demonstrated that disinfection and sterilization can affect the tensile strength of certain materials used in medical devices.
SN - 0899-8205
AD - Division of Mechanics and Materials Science, U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, HFZ-150, Rockville, Md. 20850, USA
AD - Division of Mechanics and Materials Science, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd, HFZ-150, Rockville, MD 20850
U2 - PMID: 11831098.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106932783&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2002-17543-003
AN - 2002-17543-003
AU - Onaivi, Emmanuel S.
AU - Ali, Syed F.
AU - Chirwa, Sanika S.
AU - Zwiller, Jean
AU - Thiriet, Nathalie
AU - Akinshola, B. Emmanuel
AU - Ishiguro, Hiroki
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Ibogaine signals addiction genes and methamphetamine alteration of long-term potentiation.
T2 - Cellular and molecular mechanisms of drugs of abuse II: Cocaine, substituted amphetamines, GHB, and opiates.
T3 - Annals of the New York Academy of Sciences; Vol 965
Y1 - 2002///
VL - 965
SP - 28
EP - 46
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-408-0
SN - 1-57331-409-9
AD - Onaivi, Emmanuel S., Department of Biology, William Paterson University, 300 Pompton Road, Wayne, NJ, US, 07470
N1 - Accession Number: 2002-17543-003. Partial author list: First Author & Affiliation: Onaivi, Emmanuel S.; Department of Biology, William Paterson University, Wayne, NJ, US. Release Date: 20041227. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-408-0, Hardcover; 1-57331-409-9, Paperback. Language: English. Conference Information: Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, 18th, Aug, 2001, Tortes de Manantiales, Mar del Plata, Argentina. Conference Note: This volume comprises the proceedings of the satellite meeting, entitled "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, GHB, Ibogaine, and Substituted Amphetamines" of the aforementioned conference. Major Descriptor: Alkaloids; Drug Addiction; Genes; Methamphetamine; Neural Receptors. Minor Descriptor: Animal Models; Postactivation Potentials; Long-term Potentiation. Classification: Psychopharmacology (2580). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 19.
AB - The mapping of the human genetic code will enable us to identify potential gene products involved in human addictions and diseases that have hereditary components. Thus, large-scale, parallel gene-expression studies, made possible by advances in microarray technologies, have shown insights into the connection between specific genes, or sets of genes, and human diseases. The compulsive use of addictive substances despite adverse consequences continues to affect society, and the science underlying these addictions in general is intensively studied. Pharmacological treatment of drug and alcohol addiction has largely been disappointing, and new therapeutic targets and hypotheses are needed. As the usefulness of the pharmacotherapy of addiction has been limited, an emerging potential, yet controversial, therapeutic agent is the natural alkaloid ibogaine. We have continued to investigate programs of gene expression and the putative signaling molecules used by psychostimulants such as amphetamine in in vivo and in vitro models. Our work and that of others reveal that complex but defined signal transduction pathways are associated with psychostimulant administration and that there is broad-spectrum regulation of these signals by ibogaine. We report that the actions of methamphetamine were similar to those of cocaine, including the propensity to alter long-term potentiation (LTP) in the hippocampus of the rat brain. This action suggests that there may be a 'threshold' beyond which the excessive brain stimulation that probably occurs with compulsive psychostimulant use results in the occlusion of LTP. The influence of ibogaine on immediate early genes (IEGs) and other candidate genes possibly regulated by psychostimulants and other abused substances requires further evaluation in compulsive use, reward, relapse, tolerance, craving and withdrawal reactions. It is therefore tempting to suggest that ibogaine signals addiction gene products. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ibogaine
KW - drug addiction genes
KW - methamphetamine alteration
KW - long-term potentiation
KW - animal model
KW - 2002
KW - Alkaloids
KW - Drug Addiction
KW - Genes
KW - Methamphetamine
KW - Neural Receptors
KW - Animal Models
KW - Postactivation Potentials
KW - Long-term Potentiation
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-17543-003&site=ehost-live&scope=site
UR - OnaiviE@WPUNJ.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2002-17543-008
AN - 2002-17543-008
AU - Baumann, Michael H.
AU - Phillips, Jennifer M.
AU - Ayestas, Mario A.
AU - Ali, Syed F.
AU - Rice, Kenner C.
AU - Rothman, Richard B.
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence.
T2 - Cellular and molecular mechanisms of drugs of abuse II: Cocaine, substituted amphetamines, GHB, and opiates.
T3 - Annals of the New York Academy of Sciences; Vol 965
Y1 - 2002///
VL - 965
SP - 92
EP - 108
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-408-0
SN - 1-57331-409-9
AD - Baumann, Michael H., Clinical Psychopharmacology Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD, US, 21224
N1 - Accession Number: 2002-17543-008. Partial author list: First Author & Affiliation: Baumann, Michael H.; Clinical Psychopharmacology Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD, US. Release Date: 20041227. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-408-0, Hardcover; 1-57331-409-9, Paperback. Language: English. Conference Information: Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, 18th, Aug, 2001, Tortes de Manantiales, Mar del Plata, Argentina. Conference Note: This volume comprises the proceedings of the satellite meeting, entitled "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, GHB, Ibogaine, and Substituted Amphetamines" of the aforementioned conference. Major Descriptor: Drug Dependency; Methamphetamine; Neurobiology; Rats. Minor Descriptor: Drug Therapy. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17.
AB - Methamphetamine (METH) abuse is a growing health problem, and no treatments for METH dependence have been identified. The powerful addictive properties of METH are mediated by release of dopamine (DA) from nerve terminals in mesolimbic reward pathways. METH stimulates DA release by acting as a substrate for DA transporter (DAT) proteins, thereby triggering efflux of DA from cells into the synapse. We have shown that blocking DAT activity with high-affinity DA uptake inhibitors, like GBR12909, can substantially reduce METH-evoked DA release in vitro, suggesting GBR12909 may have potential as a pharmacotherapy for METH dependence. The purpose of the present study was to examine the neurobiological effects of a long-acting oil-soluble preparation of GBR12909 (1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, or GBR-decanoate). Male rats received GBR-decanoate (480 mg/kg, i.m.) or its oil vehicle, and were tested using a variety of methods one and two weeks later. Ex vivo autoradiography showed that GBR-decanoate decreases DAT binding in DA-rich brain regions. In vivo microdialysis in the nucleus accumbens revealed that GBR-decanoate elevates baseline levels of extracellular DA and antagonizes the ability of METH to evoke DA release. The dopaminergic effects of GBR-decanoate were sustained, lasting for at least two weeks. Rats pretreated with GBR-decanoate displayed enhanced locomotor responses to novelty at one week, but not two weeks, postinjection. Administration of the D2/D3 receptor agonist quinpirole (10 and 100 μg/kg, s.c.) decreased locomotor activity and suppressed plasma prolactin levels; quinpirole-induced responses were not altered by GBR-decanoate. Thus, GBR-decanoate is able to elevate basal synaptic DA levels and block METH-evoked DA release in a persistent manner, without significant perturbation of DA receptor function. The findings suggest that GBR-decanoate, or similar long-acting agents, should be evaluated further as potential treatment adjuncts in the management of METH addiction in humans. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - GBR12909 decanoate
KW - long-acting medication
KW - methamphetamine dependence
KW - neurobiological effects
KW - rats
KW - 2002
KW - Drug Dependency
KW - Methamphetamine
KW - Neurobiology
KW - Rats
KW - Drug Therapy
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-17543-008&site=ehost-live&scope=site
UR - mbaumann@intra.nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2002-17543-010
AN - 2002-17543-010
AU - Itzhak, Yoffes
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Behavioral consequences of methamphetamine-induced neurotoxicity in mice: Relevance to the psychopathology of methamphetamine addiction.
T2 - Cellular and molecular mechanisms of drugs of abuse II: Cocaine, substituted amphetamines, GHB, and opiates.
T3 - Annals of the New York Academy of Sciences; Vol 965
Y1 - 2002///
VL - 965
SP - 127
EP - 135
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-408-0
SN - 1-57331-409-9
AD - Itzhak, Yoffes, Department of Psychiatry & Behavioral Sciences, University of Miami School of Medicine, 1011 NW 15th Street, Gautier Building, Room 503, Miami, FL, US, 33136
N1 - Accession Number: 2002-17543-010. Partial author list: First Author & Affiliation: Itzhak, Yoffes; Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, FL, US. Release Date: 20041227. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-408-0, Hardcover; 1-57331-409-9, Paperback. Language: English. Conference Information: Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, 18th, Aug, 2001, Tortes de Manantiales, Mar del Plata, Argentina. Conference Note: This volume comprises the proceedings of the satellite meeting, entitled "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, GHB, Ibogaine, and Substituted Amphetamines" of the aforementioned conference. Major Descriptor: Animal Models; Drug Addiction; Methamphetamine; Neurotoxicity; Rewards. Minor Descriptor: Mice; Psychopathology; Stimulation; Consequence. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9.
AB - Methamphetamine (METH) is a major drug of abuse in the United States. A high dose of METH given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (DA), and DA-transporter (DAT) binding sites in the striatum. In human METH-abusers, a marked decrease of the DAT in the caudate putamen was observed. Despite intensive investigations of the mechanism associated with METH-induced neurotoxicity, the behavioral consequences of this phenomenon are not clear. We used the mouse model of METH-induced neurotoxicity to investigate the response of the animals to the psychomotor-stimulating effect of METH and the rewarding effect of the drug. Mice pre-exposed to a neurotoxic dose of METH developed a marked sensitization to the psychomotor-stimulating effect of METH, which lasted for more than two months. The rewarding effect of METH was determined by the conditioned place preference (CPP) paradigm. Mice pre-exposed to the neurotoxic dose of METH showed reduced sensitivity to the rewarding effect of METH compared with control animals. While CPP was maintained for three months in the control group, the conditioned response in the METH pre-exposed animals lasted only a few days. These findings indicate that METH neurotoxicity is associated with opposing and long-lasting behavioral outcomes: (a) sensitization to the psychomotor-stimulating effect of the drug and (b) desensitization to the rewarding properties of the drug. These consequences may be relevant to the psychopathology of METH abuse. Sensitization is pertinent to compulsive drug-seeking behavior that is accompanied by desensitization to the rewarding effect of METH. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methamphetamine
KW - behavioral consequences
KW - neurotoxicity
KW - rewarding properties
KW - psychopathology
KW - mouse models
KW - addiction
KW - mice
KW - psychomotor-stimulation
KW - 2002
KW - Animal Models
KW - Drug Addiction
KW - Methamphetamine
KW - Neurotoxicity
KW - Rewards
KW - Mice
KW - Psychopathology
KW - Stimulation
KW - Consequence
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-17543-010&site=ehost-live&scope=site
UR - yitzhak@med.miami.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2002-17543-030
AN - 2002-17543-030
AU - Meyer, Jerrold S.
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Serotonergic neurotoxicity of MDMA (Ecstasy) in the developing rat brain.
T2 - Cellular and molecular mechanisms of drugs of abuse II: Cocaine, substituted amphetamines, GHB, and opiates.
T3 - Annals of the New York Academy of Sciences; Vol 965
Y1 - 2002///
VL - 965
SP - 373
EP - 380
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-408-0
SN - 1-57331-409-9
AD - Meyer, Jerrold S., Department of Psychology, University of Massachusetts, Tobin Hall, Amherst, MA, US, 01003
N1 - Accession Number: 2002-17543-030. Partial author list: First Author & Affiliation: Meyer, Jerrold S.; Department of Psychology, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA, US. Release Date: 20041227. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-408-0, Hardcover; 1-57331-409-9, Paperback. Language: English. Conference Information: Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, 18th, Aug, 2001, Tortes de Manantiales, Mar del Plata, Argentina. Conference Note: This volume comprises the proceedings of the satellite meeting, entitled "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, GHB, Ibogaine, and Substituted Amphetamines" of the aforementioned conference. Major Descriptor: Hyperthermia; Methylenedioxymethamphetamine; Neonatal Period; Neurotoxicity; Serotonin. Minor Descriptor: Brain; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8.
AB - The abused drug 3,4-methylenedioxymethamphetamine (MDMA) damages fine serotonergic fibers and nerve terminals in adult organisms; however, developing animals seem less susceptible to this effect. One proposed hypothesis is that neonates are less sensitive to MDMA neurotoxicity because they fail to show drug-induced hyperthermia. We tested this hypothesis by producing hyperthermia in neonatal rats for 2 hours after each of twice-daily MDMA (10 mg/kg sc) or saline injections given over the period from postnatal day (PD) 1 to 4. Other drug-treated and control litters were maintained at normothermic temperatures after injection. Differential core body temperatures were achieved by placing pups (without the dam) in humidified, thermostatically controlled incubators. Temperatures were monitored with a thermocouple probe at 30-minute intervals. Pups subsequently remained undisturbed until sacrifice at PD 25 and PD 60 for assessment of serotonergic damage by measuring 5-HT transporter (SERT) binding in the hippocampus and neocortex as well as 5-HT and 5-HIAA concentrations (PD 25 only). Neonatal MDMA exposure led to significant reductions in both SERT binding and 5-HT levels in the hippocampus at PD 25, independent of body temperature during treatment. Hippocampal SERT binding increased between PD 25 and PD 60 in both the MDMA and saline groups, but the MDMA-related deficit remained unchanged. Interestingly, the neocortex showed no effect of MDMA at PD 25, but SERT binding was significantly reduced at PD 60. Thus, MDMA can exert serotonergic neurotoxicity in developing animals in the absence of elevated body temperature. Hippocampal serotonergic innervation is damaged early, whereas neocortical effects emerge at a later time. Furthermore, the tendency for serotonergic recovery may be less after neonatal MDMA exposure than exposure of adult animals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serotonergic neurotoxicity
KW - 3
KW - 4-methylenedioxymethamphetamine
KW - ecstasy
KW - MDMA
KW - hyperthermia
KW - neonates
KW - rats
KW - brain
KW - 2002
KW - Hyperthermia
KW - Methylenedioxymethamphetamine
KW - Neonatal Period
KW - Neurotoxicity
KW - Serotonin
KW - Brain
KW - Rats
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-17543-030&site=ehost-live&scope=site
UR - jmeyer@psych.umass.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2002-17543-034
AN - 2002-17543-034
AU - Itzhak, Yossef
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Ali, Syed F., (Ed)
T1 - Repeated administration of gamma-hydroxybutyric acid (GHB) to mice: Assessment of the sedative and rewarding effects of GHB.
T2 - Cellular and molecular mechanisms of drugs of abuse II: Cocaine, substituted amphetamines, GHB, and opiates.
T3 - Annals of the New York Academy of Sciences; Vol 965
Y1 - 2002///
VL - 965
SP - 451
EP - 460
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-408-0
SN - 1-57331-409-9
AD - Itzhak, Yossef, Department of Psychiatry & Behavioral Sciences, University of Miami School of Medicine, 1011 NW 15 Street, Gautier Bldg. Room 503, Miami, FL, US, 33136
N1 - Accession Number: 2002-17543-034. Partial author list: First Author & Affiliation: Itzhak, Yossef; Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, FL, US. Release Date: 20041227. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-408-0, Hardcover; 1-57331-409-9, Paperback. Language: English. Conference Information: Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, 18th, Aug, 2001, Tortes de Manantiales, Mar del Plata, Argentina. Conference Note: This volume comprises the proceedings of the satellite meeting, entitled "Cellular and Molecular Mechanisms of Drugs of Abuse: Cocaine, GHB, Ibogaine, and Substituted Amphetamines" of the aforementioned conference. Major Descriptor: Acids; Drug Administration Methods; Physiological Correlates. Minor Descriptor: Mice; Rewards; Sedatives. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10.
AB - Because of the sedative/hypnotic and euphoric effects of gammahydroxybutyric acid (GHB), the recreational use of the drug has increased significantly. In the current study we investigated the sedative and rewarding effects of GHB in Swiss Webster mice. Although the acute administration of GHB (200 mg/kg) caused marked hypolocomotion, repeated administration of the drug for 6 or 14 days produced tolerance to this effect. In addition, the administration of GHB 300 mg/kg to naive mice caused catalepsy, which dissipated in mice pre-exposed to GHB (200 mg/kg). Consequently, after repeated treatment with GHB, tolerance developed to both the hypolocomotion and cataleptic effects of the drug. The administration of GHB or its precursor gammabutyrolactone for 14 days increased the striatal content of dopamine. The sedative effects of GHB may be due to hypodopaminergic activity from inhibition of dopamine release and a subsequent increase in the intraneuronal dopamine level. The rewarding effect of GHB was assessed in the conditioned place preference paradigm. Mice treated repeatedly with 250 mg/kg for 7 days developed conditioned preference for the GHB-paired compartment of the cage, suggesting that the GHB cue is rewarding. The development of tolerance to the sedative effects of GHB coupled with the rewarding properties of the drug support the abuse potential of GHB. Further studies are necessary to determine the mechanism underlying the development of tolerance to GHB and the rewarding effect of the drug. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - repeated administration
KW - sedative effects
KW - rewarding effects
KW - gammahydroxybutyric acid
KW - mice
KW - 2002
KW - Acids
KW - Drug Administration Methods
KW - Physiological Correlates
KW - Mice
KW - Rewards
KW - Sedatives
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-17543-034&site=ehost-live&scope=site
UR - yitzhak@med.miami.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
AU - Tarullo, Louisa B.
AD - US Department of Health and Human Services
A2 - Young, Mary Eming
T1 - Effective Early Childhood Programs: The U.S. Head Start Experience
T2 - From early child development to human development: Investing in our children's future
PB - Washington, D.C.:
PB - World Bank
Y1 - 2002///
SP - 219
EP - 232
N1 - Accession Number: 0739045; Reviewed Book ISBN: 0-8213-5050-1; Keywords: Childhood; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200408
KW - Analysis of Education I21
KW - Education: Government Policy I28
KW - Fertility; Family Planning; Child Care; Children; Youth J13
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0739045&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Calvin, Linda
AU - Foster, William
AU - Solorzano, Luis
AU - Mooney, J. Daniel
AU - Flores, Luis
AU - Barrios, Veronica
AD - Econ Research Services, US Department of Agriculture
AD - Pontifical Catholic U
AD - US Food and Drug Administration
AD - Guatemalan Berry Commission and High-Level Commission for Food Safety
AD - Integral Program for Agricultural and Environmental Protection, Guatemala
AD - Secretariat of Agriculture, Livestock, and Rural Development, Mexico
A2 - Krissoff, Barry
A2 - Bohman, Mary
A2 - Caswell, Julie A.
T1 - Response to a Food Safety Problem in Produce: A Case Study of a Cyclosporiasis Outbreak
T2 - Global food trade and consumer demand for quality
PB - New York; Dordrecht and London:
PB - Kluwer Academic/Plenum
Y1 - 2002///
SP - 101
EP - 127
N1 - Accession Number: 0768515; Reviewed Book ISBN: 0-306-46754-2; Keywords: Food; Safety; Geographic Descriptors: Latin America; U.S.; Geographic Region: Latin America and the Caribbean; Northern America; Publication Type: Collective Volume Article; Update Code: 200504
KW - Consumer Protection D18
KW - Consumer Protection D18
KW - Economic Development: Agriculture; Natural Resources; Energy; Environment; Other Primary Products O13
KW - International Linkages to Development; Role of International Organizations O19
KW - Agricultural Markets and Marketing; Cooperatives; Agribusiness Q13
KW - Agriculture in International Trade Q17
KW - Agricultural Policy; Food Policy Q18
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0768515&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
ID - 2008-16869-001
AN - 2008-16869-001
AU - Murphy, Lawrence R.
ED - Perrewé, Pamela L.
ED - Ganster, Daniel C.
ED - Perrewé, Pamela L., (Ed)
ED - Ganster, Daniel C., (Ed)
T1 - Job stress research at NIOSH: 1972-2002.
T2 - Historical and current perspectives on stress and health.
T3 - Research in occupational stress and well being; Vol 2; ISSN: 1479-3555 (Print)
Y1 - 2002///
VL - 2
SP - 1
EP - 55
CY - US
PB - Elsevier Science/JAI Press
SN - 1479-3555
SN - 0-7623-0970-9
SN - 978-0-7623-0970-2
N1 - Accession Number: 2008-16869-001. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; Research Psychologist, Division of Applied Science and Technology, National Institute for Occupational Safety and Health (NIOSH), US. Release Date: 20090817. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-0970-9, Hardcover; 978-0-7623-0970-2, Hardcover. Language: English. Major Descriptor: Experimentation; Occupational Stress. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 55.
AB - This chapter presents an overview of job stress research at the National Institute for Occupational Safety and Health (NIOSH) from its inception in 1972 through current and proposed research in 2002. During this 30- year period, NIOSH funded a wide range of job stress projects and a detailed account of each is not possible in a single chapter. In some cases, the research will be discussed in great depth, especially if the work was unique to NIOSH (e.g. mass psychogenic illness) or was large in magnitude (e.g. Job Demands and Worker Health study). In many other cases, however, the research will be mentioned briefly and citations provided. Since many of the early reports referenced in this chapter are long out of print, the chapter makes liberal use of 'Text Boxes' that contain sections of narrative text from NIOSH reports. The inclusion of such narrative text will provide the reader with a more authentic 'feel' for the research than would a summary statement. The chapter does not include NIOSH research in the areas of ergonomics, musculoskeletal disorders, or indoor air pollution, although psychosocial factors and job stress were elements of many studies in these areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job stress research
KW - 2002
KW - Experimentation
KW - Occupational Stress
KW - 2002
DO - 10.1016/S1479-3555(02)02001-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16869-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Sistare, Frank D.
AU - Thompson, Karol L.
AU - Honchel, Ronald
AU - DeGeorge, Joseph
T1 - Evaluation of the Tg.AC Transgenic Mouse Assay for Testing the Human Carcinogenic Potential of Pharmaceuticals—Practical Pointers, Mechanistic Clues, and New Questions.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2002/01//
VL - 21
IS - 1
M3 - Article
SP - 65
EP - 79
PB - Taylor & Francis Ltd
SN - 10915818
AB - Transgenic mouse strains with genetic alterations known to play a role in the multistage process of carcinogenesis are being used increasingly as models for evaluating the human carcinogenic potential of chemicals and pharmaceuticals. The Tg.AC transgenic mouse is one of the strains currently being used in such alternative short-term carcinogenicity testing protocols. This review is focused on recent data from studies designed to evaluate this model's ability to discriminate carcinogens from noncarcinogens. Details relating to protocol design that can significantly impact study outcome are described. Data relating to mechanisms of chemical tumor induction in the Tg.AC model are reviewed, and questions have been formulated to encourage research to further guide appropriate future applications of this model. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transgenic animals
KW - Carcinogenesis
KW - Drugs
KW - ALTERNATIVE BIOASSAY
KW - Carcinogens
KW - Skin carcinogenesis
KW - TG.AC TRANSGENIC MOUSE
KW - Tumor promotion
KW - V-HA RAS GENE
N1 - Accession Number: 6356109; Sistare, Frank D. 1; Thompson, Karol L. 1; Honchel, Ronald 1; DeGeorge, Joseph 1; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administraton, Laurel, Maryland, USA; Issue Info: Jan2002, Vol. 21 Issue 1, p65; Thesaurus Term: Transgenic animals; Thesaurus Term: Carcinogenesis; Thesaurus Term: Drugs; Author-Supplied Keyword: ALTERNATIVE BIOASSAY; Author-Supplied Keyword: Carcinogens; Author-Supplied Keyword: Skin carcinogenesis; Author-Supplied Keyword: TG.AC TRANSGENIC MOUSE; Author-Supplied Keyword: Tumor promotion; Author-Supplied Keyword: V-HA RAS GENE; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/10915810252826028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=6356109&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106927396
T1 - From the Food and Drug Administration. Caregiver grief: taking care of ourselves and our patients.
AU - Rich S
Y1 - 2002/01//2002 Jan-Mar
N1 - Accession Number: 106927396. Language: English. Entry Date: 20020531. Revision Date: 20150820. Publication Type: Journal Article; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Death
KW - Nurses -- Psychosocial Factors
KW - Family -- Psychosocial Factors
KW - Bereavement
KW - Grief
KW - Death, Sudden
KW - Death Counseling
KW - Professional-Patient Relations
KW - Information Resources
SP - 24
EP - 28
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 8
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Product Evaluation Branch II, Food and Drug Administration,l 1350 Piccard Dr, Rockville, MD 20850. E-mail: ser@cdrh.fda.gov
U2 - PMID: 11793009.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Friedman, Bernard
AD - Agency for Healthcare Research and Quality
T1 - The Use of Expensive Health Technologies in the Era of Managed Care: The Remarkable Case of Neonatal Intensive Care
JO - Journal of Health Politics, Policy and Law
JF - Journal of Health Politics, Policy and Law
Y1 - 2002///Special Issue
VL - 27
IS - 3
SP - 441
EP - 464
SN - 03616878
N1 - Accession Number: 0728599 Partial authors List; ; Keywords: Health; Managed Care; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200405
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://jhppl.dukejournals.org/content/by/year
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UR - http://jhppl.dukejournals.org/content/by/year
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 104727671
T1 - Regulatory and drug development issues related to female sexual dysfunction.
AU - Allen, Susan S
Y1 - 2002/01//
N1 - Accession Number: 104727671. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. NLM UID: 7502387.
KW - Drug Therapy -- Methods
KW - Drug and Narcotic Control
KW - Psychosexual Disorders -- Drug Therapy
KW - Clinical Trials
KW - Female
KW - Questionnaires
KW - United States
KW - United States Food and Drug Administration
SP - 11
EP - 16
JO - Journal of Sex & Marital Therapy
JF - Journal of Sex & Marital Therapy
JA - J SEX MARITAL THER
VL - 28
IS - 1
CY - Oxfordshire,
PB - Routledge
SN - 0092-623X
AD - Division of Reproductive and Urologic Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Washington, D.C., USA. allensu@cder.fda.gov
U2 - PMID: 11898693.
DO - 10.1080/00926230252851159
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Okayama, A.
AU - Stuver, S. O.
AU - Tabor, E.
AU - Tachibana, N.
AU - Kohara, M.
AU - Mueller, N. E.
AU - Tsubouchi, H.
T1 - Incident hepatitis C virus infection in a community-based population in Japan.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2002/01//
VL - 9
IS - 1
M3 - Article
SP - 43
EP - 51
SN - 13520504
AB - Hepatitis C virus (HCV) is an important cause of liver disease throughout the world. However, the natural history and pathogenesis of this infection is still not completely understood. The aim of this study was to characterize the evolution of incident, asymptomatic HCV infection in a community-based population in Japan. The Miyazaki Cohort Study is a prospective study of adult residents in two villages, one of which has a very high prevalence of HCV. Nine hundred and seventy-three people from this village were enrolled in the cohort between 1984 and 1995, with antibodies to HCV (anti-HCV) found in 23%. During subsequent visits to annual health screens, new HCV seroconverters were identified among susceptible individuals, and their sequential samples were tested for anti-HCV, HCV-RNA, and HCV core antigen. Fourteen participants (six males, eight females) acquired anti-HCV during the first 11 years of study follow-up, at an incidence rate of 362 per 100 000 person-years. Detectable HCV-RNA and high anti-HCV titres (> 1:2048) were observed for more than 5 years following seroconversion in 80% (8/10) of seroconverters with sufficient information, indicating the development of persistent infection in these subjects. Three (37.5%) of the eight sero converters with persistent infection had fairly consistent, albeit mild, alanine aminotransferase elevations (30–130 IU/L) during the study. Anti-HCV seroconversions occurred at a very high rate in this community-based population in Japan, in which this infection is endemic. Persistence also developed at a high frequency among the cases of newly acquired infection, although the associated liver enzyme abnormalities were mild. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - LIVER diseases
KW - JAPAN
KW - cohort study
KW - hepatitis C virus
KW - incidence
KW - seroepidemiologic methods
N1 - Accession Number: 5820818; Okayama, A. 1; Stuver, S. O. 2; Tabor, E. 3; Tachibana, N. 1; Kohara, M. 4; Mueller, N. E. 2; Tsubouchi, H. 1; Source Information: Jan2002, Vol. 9 Issue 1, p43; Subject: HEPATITIS C virus; Subject: LIVER diseases; Geographic Terms: JAPAN; Author-Supplied Keyword: cohort study; Author-Supplied Keyword: hepatitis C virus; Author-Supplied Keyword: incidence; Author-Supplied Keyword: seroepidemiologic methods; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2893.2002.00331.x
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DP - EBSCOhost
DB - hch
ER -
TY - CHAP
AU - Bailar, John C., III
AU - Bailar, A. John
AD - U Chicago
AD - Miami U and National Institute for Occupational Safety and Health
A2 - McCally, Michael
T1 - The Science of Risk Assessment
T2 - Life support: The environment and human health
PB - Cambridge and London:
PB - MIT Press
Y1 - 2002///
SP - 231
EP - 238
N1 - Accession Number: 0734663; Reviewed Book ISBN: 0-262-13414-4; 0-262-63257-8; Keywords: Risk Assessment; Risk; Publication Type: Collective Volume Article; Update Code: 200407
KW - Criteria for Decision-Making under Risk and Uncertainty D81
KW - Valuation of Environmental Effects Q51
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Reilly, Thomas
AD - US Agency for Healthcare Research and Quality
A2 - Smith, Peter
T1 - Providing Performance Information for Consumers: Experience from the United States
T2 - Measuring up: Improving health system performance in OECD countries
PB - Paris and Washington, D.C.:
PB - Organisation for Economic Co-operation and Development
Y1 - 2002///
SP - 97
EP - 116
N1 - Accession Number: 0758698 Partial authors List; ; Reviewed Book ISBN: 92-64-19676-5; ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200501
KW - National Government Expenditures and Health H51
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
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DP - EBSCOhost
DB - ecn
ER -
TY - NEWS
AU - Ferguson, Sherry A.
T1 - Effects on brain and behavior caused by developmental exposure to endocrine disrupters with estrogenic effects
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2002/01//
VL - 24
IS - 1
M3 - Editorial
SP - 1
SN - 08920362
KW - Behavior
KW - Brain
KW - Development
KW - Endocrine disrupter
KW - Estrogen
N1 - Accession Number: 7751570; Ferguson, Sherry A. 1; Email Address: sferguson@nctr.fda.gov; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA; Issue Info: Jan2002, Vol. 24 Issue 1, p1; Author-Supplied Keyword: Behavior; Author-Supplied Keyword: Brain; Author-Supplied Keyword: Development; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: Estrogen; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106902171
T1 - Device safety. Problems after vacuum-assisted childbirth.
AU - Dwyer D
AU - Swayze S
Y1 - 2002/01//
N1 - Accession Number: 106902171. Language: English. Entry Date: 20050817. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Vacuum Extraction, Obstetrical -- Adverse Effects -- In Infancy and Childhood
KW - Birth Injuries
KW - Hematoma -- Etiology -- In Infancy and Childhood
KW - Cerebral Hemorrhage -- Etiology -- In Infancy and Childhood
KW - Infant, Newborn
SP - 74
EP - 74
JO - Nursing
JF - Nursing
JA - NURSING
VL - 32
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health Food and Drug Administration, Rockville, Md
U2 - PMID: 12929681.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106955532
T1 - Exposure to crystalline silica, silicosis, and lung disease other than cancer in diatomaceous earth industry workers: a quantitative risk assessment.
AU - Park R
AU - Rice F
AU - Stayner L
AU - Smith R
AU - Gilbert S
AU - Checkoway H
Y1 - 2002/01//
N1 - Accession Number: 106955532. Language: English. Entry Date: 20020830. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Lung Diseases -- Mortality
KW - Occupational Diseases -- Mortality
KW - Occupational Exposure
KW - Pneumoconiosis -- Etiology
KW - Air Pollution -- Adverse Effects
KW - California
KW - Industry
KW - Models, Statistical
KW - Risk Assessment
KW - Risk Factors
KW - Retrospective Design
KW - Prospective Studies
KW - Regression
KW - Data Analysis Software
KW - Epidemiological Research
KW - Odds Ratio
KW - Confounding
KW - Human
SP - 36
EP - 43
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 59
IS - 1
PB - BMJ Publishing Group
AB - OBJECTIVES: To estimate excess lifetime risk of (a) mortality from lung disease other than cancer (LDOC), and, (b) onset of radiographic silicosis, arising from occupational exposure to respirable crystalline silica dust. METHODS: Data from a cohort of California diatomaceous earth mining and processing workers exposed to crystalline silica dust (mainly as cristobalite) were reanalyzed with Poisson regression methods with internal and external adjustments for potential confounding by calendar time, age, smoking, Hispanic ethnicity, and time since first observation. Model fit was evaluated by comparing deviances and fitting cubic spline models. Lifetime risks of death from LDOC and radiographic silicosis were estimated up to age 85 with an actuarial approach accounting for competing causes of death. RESULTS: For deaths due to LDOC, a linear relative rate model gave the best fit in Poisson regression analyses. At the mean cumulative exposure of LDOC cases to silica, after adjustment for smoking, the estimated rate ratio was 4.2 (p<0.0001); at the maximum cumulative exposure of cases, the rate ratio was 18.4. The excess lifetime risk for white men exposed to respirable cristobalite dust for 45 years at the current permissible exposure limit (PEL; about 0.05 mg/m(3)) of the Occupational Safety and Health Administration was 54/1000 (95% confidence interval (95% CI) 17 to 150). For 70 incident cases of radiographic silicosis largely manifest before the end of employment, the best fit was also the linear relative rate model, predicting a rate ratio of 25.6 for silicosis at the mean cumulative exposure of the cases (p<0.0001). The excess lifetime risk for silicosis at the current PEL was 75/1000. CONCLUSION: Current occupational health standards for crystalline silica permit risks of lung disease other than cancer far in excess of what is usually considered acceptable by the Occupational Safety and Health Administration (a lifetime risk of less than one in a thousand deaths).
SN - 1351-0711
AD - US Dept of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-15, Cincinnati, OH 45226-1998; rhp9@cdc.gov
U2 - PMID: 11836467.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106980254
T1 - Substance abuse in the workplace: epidemiology, effects, and industry response.
AU - Bush DM
AU - Autry JH III
Y1 - 2002/01//2002 Jan-Mar
N1 - Accession Number: 106980254. Language: English. Entry Date: 20021122. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Substance Abuse -- United States
KW - Work Environment
KW - United States
KW - Surveys
KW - Substance Abuse -- Epidemiology
KW - Program Evaluation
KW - Substance Abuse Detection
KW - Government Programs
KW - Productivity
KW - Government Agencies
KW - Americans with Disabilities Act
SP - 13
EP - 25
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 17
IS - 1
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - The Substance Abuse and Mental Health Services Administration's National Household Survey on Drug Abuse (NHSDA) reveals self-reported information on illicit drug and alcohol use among full-time, part-time, and unemployed U.S. workers, including information on workplace policies, workers' health, productivity, absenteeism, job turnover rates, accidents, and injuries. Selected statistics from 1985, 1993, and 1999 NHSDAs are reviewed in this chapter, with focus on the effectiveness and outcomes of a comprehensive Drug-Free Workplace Program, including industry and employee response and the effects of a drug testing program.
SN - 0885-114X
AD - Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockwall II, Suite 815, Rockville, MD 20857
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hediger, Mary L.
AU - Overpeck, Mary D.
AU - Ruan, W. June
AU - Troendle, James F.
T1 - Birthweight and gestational age effects on motor and social development.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2002/01//
VL - 16
IS - 1
M3 - Article
SP - 33
EP - 46
SN - 02695022
AB - Summary The number of children at risk for delays in motor and social development (MSD) associated with preterm delivery and low birthweight is increasing, but such children are generally not seen as being in need of evaluation. The objective of these analyses was to determine whether there are independent effects of birthweight and gestational age on MSD and the magnitude of effects. Subjects were a representative sample of 4621 US-born singleton children, aged 2–47 months, examined in the third National Health and Nutrition Examination Survey (1988–94). MSD was assessed using an age-appropriate scale. Birthweight and gestational age were taken from birth certificates. Mexican–American and ‘other’ race/ethnicity (other than non-Hispanic white, non-Hispanic black or Mexican–American), low parental education level, older maternal age, higher birth order, low birthweight (LBW, <2500 g) and preterm delivery (<37 weeks) were all found to be associated with significant (P < 0.01) delays in MSD. Three per cent of the infants and children were preterm LBW and 2.2% term LBW (<2500 g, 37–44 weeks). Adjusting for socio-demographic factors, preterm LBW children had lower MSD scores (-1.5 ± 0.3 points, P < 0.0001) through early childhood, as did term LBW children (-0.8 ± 0.4 points, P < 0.03). For females, LBW was the most important perinatal predictor of a lowered score (-0.9 ± 0.3 points compared with normal birthweight, P < 0.04). For males, scores were additionally decreased by –0.1 ± 0.03 points/week (P = 0.001) of early delivery. LBW children had less muscle mass, but adjusting for muscularity did not diminish the effects of birth size on MSD. LBW status and preterm delivery are associated independently with small, but measurable, delays in MSD through early childhood and should be considered along with other known risk factors for development delays in determining the need for developmental... [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD development
KW - BIRTH weight
KW - GESTATIONAL age
N1 - Accession Number: 7287200; Hediger, Mary L. 1; Overpeck, Mary D. 1,2; Ruan, W. June 1; Troendle, James F. 1; Source Information: Jan2002, Vol. 16 Issue 1, p33; Subject: CHILD development; Subject: BIRTH weight; Subject: GESTATIONAL age; Number of Pages: 14p; Document Type: Article
L3 - 10.1046/j.1365-3016.2002.00393.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=7287200&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Tabacova, Sonia A.
AU - Kimmel, Carole A.
T1 - Atenolol: pharmacokinetic/dynamic aspects of comparative developmental toxicity☆ ☆ The views expressed in this paper are those of the authors, and do not necessarily represent the views or policies of the US Environmental Protection Agency or the Food, and Drug Administration.
PB - Springer Science & Business Media B.V.
AB - OBJECTIVE: This paper examines risk factors for twin preterm birth in 1981-82 and 1996-97 in the United States in order to see if they have changed over time. METHODS: We studied all U.S. twin births for the years examined (N = 346, 567). Since the gestational age distributions for twins differs from singletons, the risk of preterm birth was examined at <33, 33-34, and 35-36 weeks. Logistic regression was used to examine the contributions of sociodemographic and obstetric factors at each period. RESULTS: While the <33 week twin preterm rate rose 7% from 1981-82 to 1996-97, the 33-34-week rate rose 31%, and the 35-36-week rate rose 51%. Women with less education, teenagers, unmarried women, primiparas, and blacks were more likely to deliver preterm across all three preterm birth levels. However, the effect of these low socioeconomic status markers diminished over the study period. Additionally, the odds of preterm birth among blacks increased with earlier gestational ages. Women who had intensive prenatal care utilization as compared with less than adequate utilization were more likely to deliver preterm (35-36 weeks) in 1996-97 (odds ratio (OR) = 2.05) compared with 1981-82 (OR = 1.44). Smaller increases were noted for <33 and 33-34 weeks. CONCLUSIONS: Obstetric factors appear to be playing a greater role in the rise of twin preterm births at 35-36 weeks gestation. Temporal sociodemographic changes do not explain the rise in the preterm rate. Changing clinical practices may be having unintended consequences on the public health goals of reducing preterm and low birthweight rates in the United States.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857. E-mail: mkogan@hrsa.gov
U2 - PMID: 11926251.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kogan, Michael D.
AU - Alexander, Greg R.
AU - Kotelchuck, Milton
AU - MacDorman, Marian F.
AU - Buekens, Pierre
AU - Papiernik, Emile
T1 - A Comparison of Risk Factors for Twin Preterm Birth in the United States Between 1981–82 and 1996–97.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2002/03//
VL - 6
IS - 1
M3 - Article
SP - 29
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objective : This paper examines risk factors for twin preterm birth in 1981–82 and 1996–97 in the United States in order to see if they have changed over time. Methods : We studied all U.S. twin births for the years examined (N = 346,567). Since the gestational age distributions for twins differs from singletons, the risk of preterm birth was examined at <33, 33–34, and 35–36 weeks. Logistic regression was used to examine the contributions of sociodemographic and obstetric factors at each period. Results : While the <33 week twin preterm rate rose 7% from 1981–82 to 1996–97, the 33–34-week rate rose 31%, and the 35–36-week rate rose 51%. Women with less education, teenagers, unmarried women, primiparas, and blacks were more likely to deliver preterm across all three preterm birth levels. However, the effect of these low socioeconomic status markers diminished over the study period. Additionally, the odds of preterm birth among blacks increased with earlier gestational ages. Women who had intensive prenatal care utilization as compared with less than adequate utilization were more likely to deliver preterm (35–36 weeks) in 1996–97 (odds ratio (OR) = 2.05) compared with 1981–82 (OR = 1.44). Smaller increases were noted for <33 and 33–34 weeks. Conclusions : Obstetric factors appear to be playing a greater role in the rise of twin preterm births at 35–36 weeks gestation. Temporal sociodemographic changes do not explain the rise in the preterm rate. Changing clinical practices may be having unintended consequences on the public health goals of reducing preterm and low birthweight rates in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTETRICS
KW - TWINS
KW - BIRTH weight
KW - PUBLIC health
KW - UNITED States
KW - obstetric practices
KW - preterm birth
KW - racial disparities
KW - twins
KW - United States
N1 - Accession Number: 11307887; Kogan, Michael D. 1; Email Address: mkogan@hrsa.gov; Alexander, Greg R. 2; Kotelchuck, Milton 3; MacDorman, Marian F. 4; Buekens, Pierre 5; Papiernik, Emile 2,6; Source Information: Mar2002, Vol. 6 Issue 1, p29; Subject: OBSTETRICS; Subject: TWINS; Subject: BIRTH weight; Subject: PUBLIC health; Geographic Terms: UNITED States; Author-Supplied Keyword: obstetric practices; Author-Supplied Keyword: preterm birth; Author-Supplied Keyword: racial disparities; Author-Supplied Keyword: twins; Author-Supplied Keyword: United States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Ge, Beilei
AU - Zhao, Shaohua
AU - Hall, Robert
AU - Meng, Jianghong
T1 - A PCR–ELISA for detecting Shiga toxin-producing Escherichia coli
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2002/03//
VL - 4
IS - 3
M3 - Article
SP - 285
SN - 12864579
AB - A sensitive and specific PCR–ELISA was developed to detect Escherichia coli O157:H7 and other Shiga toxin-producing E. coli (STEC) in food. The assay was based on the incorporation of digoxigenin-labeled dUTP and a biotin-labeled primer specific for Shiga toxin genes during PCR amplification. The labeled PCR products were bound to streptavidin-coated wells of a microtiter plate and detected by an ELISA. The specificity of the PCR was determined using 39 bacterial strains, including STEC, enteropathogenic E. coli, E. coli K12, and Salmonella. All of the STEC strains were positive, and non-STEC organisms were negative. The ELISA detecting system was able to increase the sensitivity of the PCR assay by up to 100-fold, compared with a conventional gel electrophoresis. The detection limit of the PCR–ELISA was 0.1–10 CFU dependent upon STEC serotypes, and genotypes of Shiga toxins. With the aid of a simple DNA extraction system, PrepMan, the PCR–ELISA was able to detect ca. 105 CFU of STEC per gram of ground beef without any culture enrichment. The entire procedure took about 6 h. Because of its microtiter plate format, PCR–ELISA is particularly suitable for large-scale screening and compatible with future automation. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial toxins
KW - Polymerase chain reaction
KW - Enzyme-linked immunosorbent assay
KW - ELISA
KW - PCR
KW - Shiga toxin-producing E. coli
N1 - Accession Number: 7770941; Ge, Beilei 1; Zhao, Shaohua 1; Hall, Robert 2; Meng, Jianghong 1; Email Address: jm332@umail.umd.edu; Affiliations: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW Washington, DC 20204, USA; Issue Info: Mar2002, Vol. 4 Issue 3, p285; Thesaurus Term: Bacterial toxins; Subject Term: Polymerase chain reaction; Subject Term: Enzyme-linked immunosorbent assay; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Shiga toxin-producing E. coli; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tao Chen
AU - Harrington-Brock, Karen
AU - Moore, Martha M.
T1 - Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK+/–-3.7.2C mouse lymphoma cells.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2002/03//
VL - 17
IS - 2
M3 - Article
SP - 105
EP - 109
PB - Oxford University Press / USA
SN - 02678357
AB - N-ethyl-N-nitrosourea (ENU) is a potent monofunctional ethylating agent that has been found to be mutagenic in a wide variety of organisms from viruses to mammalian germ cells. To elucidate the mutagenicity of ENU at the Tk+/– locus of mouse lymphoma cells and to confirm the ability of the mouse lymphoma assay (MLA) to detect both point mutations and large DNA alterations, Tk+/– L5178Y cells were exposed to different doses of ENU. Treatment of the cells with ENU resulted in a linear dose response with mutant frequencies of up to 16-fold over control. Evaluation of mutant clone size showed that 36% of the 100 μg/ml ENU-induced clones (66% in control) were small colony mutants and 64% (34% in control) were large colony mutants. DNA isolated from mutants in the control culture and the 100 μg/ml ENU treatment group was analyzed for loss of heterozygosity (LOH) using allele-specific PCR. The majority of the small colony mutants, both ENU-treated (97%) and spontaneous (91%), lost the Tk1b allele. The percentage of allele loss in ENU-induced large colony mutants was distinctly different from that of the control. Twenty-three percent of ENU-induced large colony mutants lost their Tk1b alleles, whereas 73% of the large colony mutants from the control culture lost the allele (P < 0.001). Overall, 50% of the Tk mutants from the 100 μg/ml ENU-treated cultures (86% in control) showed LOH. Our data indicate that ENU is a potent mutagen in mouse lymphoma cells and that 100 μg/ml ENU induces equal numbers of point mutations and chromosomal mutations. This study serves to verify that the MLA detects both point mutations and chromosomal mutations. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutagenicity testing
KW - Locus (Genetics)
KW - Mutagenesis
KW - DNA
KW - Chromosomes
KW - Mice as laboratory animals
N1 - Accession Number: 44404292; Tao Chen; Harrington-Brock, Karen; Moore, Martha M. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Issue Info: Mar2002, Vol. 17 Issue 2, p105; Thesaurus Term: Mutagenicity testing; Thesaurus Term: Locus (Genetics); Subject Term: Mutagenesis; Subject Term: DNA; Subject Term: Chromosomes; Subject Term: Mice as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Suzanne M.
T1 - A role for p53 in the frequency and mechanism of mutation
JO - Mutation Research/Reviews in Mutation Research
JF - Mutation Research/Reviews in Mutation Research
Y1 - 2002/03//
VL - 511
IS - 1
M3 - Article
SP - 45
SN - 13835742
AB - The tumor suppressor protein, p53, is often referred to as the guardian of the genome. When p53 function is impaired, its ability to preserve genomic integrity is compromised. This may result in an increase in mutation on both a molecular and chromosomal level and contribute to the progression to a malignant phenotype. In order to study the effect of p53 function on the acquisition of mutation, in vitro and in vivo models have been developed in which both the frequency and mechanism of mutation can be analyzed. In human lymphoblastoid cells in which p53 function was impaired, both the spontaneous and induced mutant frequency increased at the autosomal thymidine kinase (TK) locus. The mutant frequency increased to a greater extent in cell lines in which p53 harbored a point mutation than in those lines in which a “null” mutation had been introduced by molecular targeting or by viral degradation indicating a possible “gain-of-function” associated with the mutant protein. Further, molecular analysis revealed that the loss of p53 function was associated with a greater tendency towards loss-of-heterozygosity (LOH) within the TK gene that was due to non-homologous recombination than that found in wild-type cells. Most data obtained from the in vivo models uses the LacI reporter gene that does not efficiently detect mutation that results in LOH. However, studies that have examined the effect of p53 status on mutation in the adenine phosphoribosyl transferase (APRT) gene in transgenic mice also suggest that loss of p53 function results in an increase in mutation resulting from non-homologous recombination. The results of these studies provide clear and convincing evidence that p53 plays a role in modulating the mutant frequency and the mechanism of mutation. In addition, the types of mutation that occur within the p53 gene are also of importance in determining the mutant frequency and the pathways leading to mutation. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Reviews in Mutation Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - p53 antioncogene
KW - Loss-of-function
KW - Mutant p53
KW - p53
KW - p53 knockout
N1 - Accession Number: 7770677; Morris, Suzanne M. 1; Email Address: smorris@nctr.fda.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Mar2002, Vol. 511 Issue 1, p45; Thesaurus Term: Mutation (Biology); Subject Term: p53 antioncogene; Author-Supplied Keyword: Loss-of-function; Author-Supplied Keyword: Mutant p53; Author-Supplied Keyword: p53; Author-Supplied Keyword: p53 knockout; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Popke, E.J.
AU - Patton, R.
AU - Newport, G.D.
AU - Rushing, L.G.
AU - Fogle, C.M.
AU - Allen, R.R.
AU - Pearson, E.C.
AU - Hammond, T.G.
AU - Paule, M.G.
T1 - Assessing the potential toxicity of MK-801 and remacemide:: Chronic exposure in juvenile rhesus monkeys
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2002/03//
VL - 24
IS - 2
M3 - Article
SP - 193
SN - 08920362
AB - The present experiment examined the effects of chronic exposure to either 0.1 or 1.0 mg/kg MK-801 [a selective N-methyl-d-aspartate (NMDA) receptor antagonist] or 20.0 or 50.0 mg/kg remacemide (an NMDA receptor antagonist which also blocks fast sodium channels) in juvenile rhesus monkeys. Endpoints were monitored to provide a general index of subjects'' health and included measures of clinical chemistry, hematology, ophthalmology, spontaneous home-cage behavior, and peak drug plasma levels. In general, both drugs were well tolerated and produced no treatment-related effects during 2 years of dosing and assessment. Periodic plasma drug level determinations provided limited evidence that both compounds may induce their own metabolism. The present results contrast sharply with previously reported effects of long-lasting impairments in the acquisition of incremental learning and in the development of color and position discrimination in these same subjects. These observations highlight the importance of collecting a broad range of toxicology data, including tests of cognitive function, to make comprehensive assessments of new drug safety. In the present case, the less obvious effects of these drugs on cognition defined the toxicologic response. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Methyl aspartate
KW - Sodium channels
KW - Clinical chemistry
KW - Hematology
KW - Fast sodium channels
KW - Home-cage behavior
KW - MK-801
KW - N-Methyl-d-aspartate (NMDA)
KW - Ophthalmology
KW - Remacemide
KW - Rhesus monkeys
N1 - Accession Number: 7779700; Popke, E.J. 1; Patton, R. 2; Newport, G.D. 1; Rushing, L.G. 3; Fogle, C.M. 1; Allen, R.R. 4; Pearson, E.C. 5; Hammond, T.G. 5; Paule, M.G. 1; Email Address: mpaule@nctr.fda.gov; Affiliations: 1: Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Road, Jefferson, AR 72079-950, USA; 2: Charles River Laboratories, P.O. Box 26, 3900 NCTR Road, Jefferson AR, USA; 3: Division of Chemistry, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR, USA; 4: Peak Statistical Services, 5691 Northwood Drive, Evergreen, CO, USA; 5: Safety Assessment, AstraZeneca, Bakewell Road, Loughborough-Leics LE11 5RH, Loughborough, England, UK; Issue Info: Mar2002, Vol. 24 Issue 2, p193; Subject Term: Methyl aspartate; Subject Term: Sodium channels; Subject Term: Clinical chemistry; Subject Term: Hematology; Author-Supplied Keyword: Fast sodium channels; Author-Supplied Keyword: Home-cage behavior; Author-Supplied Keyword: MK-801; Author-Supplied Keyword: N-Methyl-d-aspartate (NMDA); Author-Supplied Keyword: Ophthalmology; Author-Supplied Keyword: Remacemide; Author-Supplied Keyword: Rhesus monkeys; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Temple, John G.
AU - Miller, Diane B.
AU - Barthalmus, George T.
T1 - Differential vulnerability of snake species to MPTP:: A behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia)
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2002/03//
VL - 24
IS - 2
M3 - Article
SP - 227
SN - 08920362
AB - The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behavioral and biochemical effects of MPTP were assessed in the black ratsnake Elaphe o. obsoleta and the banded watersnake Nerodia f. fasciata—species that display contrasting behavioral sensitivities to dopaminergic antagonists and to amphibian toxins. We report that MPTP induces depletion of norepinephrine and serotonin in fore, mid and hindbrain regions and depletion of dopamine in fore and midbrain regions in E.o. obsoleta. MPTP also induced a marked reduction in righting ability in E.o. obsoleta. In N.f. fasciata, norepinephrine and dopamine were depleted by MPTP in all three brain regions and serotonin was only significantly reduced in the forebrain. In contrast to E.o. obsoleta, N.f. fasciata demonstrated no behavioral disorders. This study demonstrates a behavioral and biochemical sensitivity to MPTP in E.o. obsoleta that differs from that in N.f. fasciata. The differential sensitivities to monoaminergic modulation may be related to the contrasting diets of these species. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Reptiles
KW - Methylphenyltetrahydropyridine
KW - Dopamine
KW - Serotonin
KW - Motor control
KW - MPTP
KW - Reptile
N1 - Accession Number: 7779703; Temple, John G. 1; Email Address: jtemple@mwc.edu; Miller, Diane B. 2; Barthalmus, George T. 3; Affiliations: 1: Department of Biological Sciences, Mary Washington College, Fredericksburg, VA 22401, USA; 2: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; 3: Department of Zoology, North Carolina State University, Raleigh, NC 27695-7617, USA; Issue Info: Mar2002, Vol. 24 Issue 2, p227; Thesaurus Term: Reptiles; Subject Term: Methylphenyltetrahydropyridine; Subject Term: Dopamine; Subject Term: Serotonin; Author-Supplied Keyword: Motor control; Author-Supplied Keyword: MPTP; Author-Supplied Keyword: Reptile; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morata, Thais C.
T1 - Interaction between Noise and Asphyxiants: A Concern for Toxicology and Occupational Health.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/03//
VL - 66
IS - 1
M3 - Article
SP - 1
EP - 3
PB - Oxford University Press / USA
SN - 10966080
AB - The article highlighted in this issue is “Potentiation of Noise-Induced Hearing Loss by Low Concentrations of Hydrogen Cyanide in Rats” by Laurence D. Fechter, Guang-Di Chen, and David L. Johnson (pp. 131–138). [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Periodicals -- Articles
KW - Noise-induced deafness
KW - Hydrocyanic acid
KW - Rats as laboratory animals
KW - Fechter, Laurence D.
KW - Johnson, David L.
KW - Guang-Di Chen
N1 - Accession Number: 44406250; Morata, Thais C. 1; Email Address: tmorata@cdc.gov; Affiliations: 1: Hearing Loss Prevention Section, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, C27, 4676 Columbia Parkway, Cincinnati, Ohio 45226; Issue Info: Mar2002, Vol. 66 Issue 1, p1; Subject Term: Periodicals -- Articles; Subject Term: Noise-induced deafness; Subject Term: Hydrocyanic acid; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; People: Fechter, Laurence D.; People: Johnson, David L.; People: Guang-Di Chen; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Djuric, Zora
AU - Lewis, Sherry M.
AU - Lu, Ming H.
AU - Mayhugh, Martha
AU - Naegeli, Lilian
AU - Ning Tang
AU - Hart, Ronald W.
T1 - Effect of Varying Caloric Restriction Levels on Female Rat Growth and 5-Hydroxymethyl-2′-deoxyuridine in DNA.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/03//
VL - 66
IS - 1
M3 - Article
SP - 125
EP - 130
PB - Oxford University Press / USA
SN - 10966080
AB - Caloric restriction has previously been shown to decrease levels of oxidative stress in rats. In this study, we examined the effects of 5 different caloric intake levels on one type of oxidative DNA damage in rat mammary gland, blood, and liver. Animals were fed modified AIN-93G diets to accommodate 10, 20, 30, or 40% calorie restriction (CR), relative to ad libitum (AL) consumption. The intakes of fat, protein, vitamins, and minerals thus remained constant, but total carbohydrate intake decreased. Body weights of the animals at 20 weeks reflected the degree of restriction, but in the first 10 weeks, weight gain in the 10% CR group was not reduced relative to animals fed ad libitum. Levels of 5-hydroxymethyl-2′-deoxyuridine increased with time in mammary gland and nucleated blood cells regardless of CR level, indicating an effect of animal age, despite the fact that the animals were only 7 months old after the 20-week dietary study. In liver, however, there was a trend towards decreased DNA damage levels with time. The effect of diet on levels of 5-hydroxymethyl-2′-deoxyuridine was not statistically significant, indicating no protective effect of restricted dietary carbohydrate. This dietary study differed from previous work in that the modified AIN-93G dietary formulation contains relatively higher levels of fat and vitamins K, E, and B12, and it has certain added trace minerals. This data raises the question of whether the previously reported effects of calorie restriction on preventing oxidative stress in mammary gland are dependent on the type of dietary formulation used. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA damage
KW - Low-calorie diet
KW - Oxidative stress
KW - Aging
KW - Rats as laboratory animals
KW - 5-hydroxymethyl-2′-deoxyuridine
KW - 5-hydroxymethyl-2'-deoxyuridine
KW - aging
KW - caloric restriction
KW - female rats
KW - oxidative stress
N1 - Accession Number: 44406263; Djuric, Zora 1; Email Address: djuricz@karmanos.org; Lewis, Sherry M. 2; Lu, Ming H. 2; Mayhugh, Martha 2; Naegeli, Lilian 1; Ning Tang 2; Hart, Ronald W. 2; Affiliations: 1: Barbara Ann Karmanos Cancer Institute, Wayne State University, 100 E. Warren, Detroit, Michigan 48118; 2: National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Mar2002, Vol. 66 Issue 1, p125; Thesaurus Term: DNA damage; Subject Term: Low-calorie diet; Subject Term: Oxidative stress; Subject Term: Aging; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: 5-hydroxymethyl-2′-deoxyuridine; Author-Supplied Keyword: 5-hydroxymethyl-2'-deoxyuridine; Author-Supplied Keyword: aging; Author-Supplied Keyword: caloric restriction; Author-Supplied Keyword: female rats; Author-Supplied Keyword: oxidative stress; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-02768-004
AN - 2002-02768-004
AU - Kirby, James B.
T1 - The influence of parental separation on smoking initiation in adolescents.
JF - Journal of Health and Social Behavior
JO - Journal of Health and Social Behavior
JA - J Health Soc Behav
Y1 - 2002/03//
VL - 43
IS - 1
SP - 56
EP - 71
CY - US
PB - American Sociological Assn
SN - 0022-1465
SN - 2150-6000
AD - Kirby, James B., Agency for Healthcare Research & Quality, 2101 E. Jefferson St., Suite 500, Rockville, MD, US, 20852
N1 - Accession Number: 2002-02768-004. PMID: 11949197 Other Journal Title: Journal of Health & Human Behavior. Partial author list: First Author & Affiliation: Kirby, James B.; Agency for Healthcare Research & Quality, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20020515. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Divorce; Tobacco Smoking. Minor Descriptor: Depression (Emotion); Distress; Self-Esteem. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 16. Issue Publication Date: Mar, 2002.
AB - Examined the influence of parental separation on smoking initiation using a large representative sample of adolescents interviewed at 2 points in time. Data were taken from waves 1 and 2 (approximately 1 yr after the 1st interview) of the National Longitudinal Study of Adolescent Health. Ss were a subset of 3,403 adolescents in the 7th-12th grades who lived with 2 parents at wave 1 (and thus, were at risk of experiencing a parental divorce or separation) and who were non-smokers at wave 1. Ss completed measures of smoking initiation, parental separation, parent-child closeness, maternal supervision, number of smoking friends, depressed mood, self-esteem, and rebelliousness. It was hypothesized that parental separation would increase the likelihood of smoking initiation by increasing psychological distress, depressed mood, and rebelliousness, and by decreasing self esteem. Findings indicate that parental separation increases the likelihood that adolescents will start smoking. It is suggested that parental separation has this effect in part by raising depressive symptoms and rebelliousness in adolescents. Despite the significance of these indirect effects, it is concluded that the bulk of the effect of parental separation on smoking initiation is direct. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental separation
KW - smoking initiation
KW - psychological distress
KW - depressed mood
KW - rebelliousness
KW - self esteem
KW - adolescents
KW - 2002
KW - Adolescent Development
KW - Divorce
KW - Tobacco Smoking
KW - Depression (Emotion)
KW - Distress
KW - Self-Esteem
KW - 2002
DO - 10.2307/3090245
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-02768-004&site=ehost-live&scope=site
UR - jkirby@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - KOICHI HONMA
AU - VAL VALLYATHAN
T1 - Rheumatoid Pneumoconiosis: A Comparative Study of Autopsy Cases between Japan and North America.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/03/02/2002 Supplement
VL - 46
M3 - Article
SP - 265
EP - 267
SN - 00034878
AB - In order to elucidate the prevalence of rheumatoid pneumoconiosis (RP), an extensive review was conducted of pathological specimens from a large series of autopsy cases both in Japan and the USA (National institute for Occupational Safety and Health). Twenty-two cases were pathologically identified as having RP among 2450 autopsied coal workers with pneumoconiosis in the USA (0.89%) and its prevalence was comparable with that of Japanese RP cases (n = 9) among 1217 pneumoconiotics (0.74%). RP consisted of two subtypes, Caplan type and silicotic type. All Japanese cases were of the silicotic type (0.82%). In the USA 14 were of Caplan type (0.37%) and 8 silicotic (1.5%). Although RP is an uncommon disease, silicotics are relatively more prone to develop RP compared with other types of pneumoconiotics. The incidence of tuberculosis was significantly higher (9.1%) among RP cases than the non-rheumatoid population (1.5%) only in the US cases (P < 0.01). [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - pneumoconiosis
KW - rheumatoid arthritis
KW - rheumatoid nodule
KW - silicosis
N1 - Accession Number: 109118866; KOICHI HONMA 1; Email Address: honma@dokkyomed.ac.jp; VAL VALLYATHAN 2; Affiliations: 1: Department of Pathology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 3210293, Japan; 2: Pathology and Physiology Section, National Institute for Occupational Safety and Health, Willowdale Road 1095, Morgantown, WV 26505, USA; Issue Info: 2002 Supplement, Vol. 46, p265; Author-Supplied Keyword: pneumoconiosis; Author-Supplied Keyword: rheumatoid arthritis; Author-Supplied Keyword: rheumatoid nodule; Author-Supplied Keyword: silicosis; Number of Pages: 3p; Document Type: Article
L3 - 10.1093/annhyg/mef704
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MAYNARD, A. D.
AU - ZIMMER, A. T.
T1 - Evaluation of Grinding Aerosols in Terms of Alveolar Dose: the Significance of Using Mass, Surface Area and Number Metrics.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/03/02/2002 Supplement
VL - 46
M3 - Article
SP - 315
EP - 319
SN - 00034878
AB - Aerosols generated by mechanical means are generally assumed to have low particle number and surface area concentrations compared with mass concentration. As a result, they have received little attention in the current debate over the use of number- and surface area-based metrics for low-solubility particles. However, it is plausible that some high-energy mechanical processes found in workplaces may lead to the generation of fine aerosols that are characterized by high number and surface area concentrations. A preliminary investigation has been carried out into the aerosol generated during high-speed grinding to investigate the generation of fine particles from mechanical processes. Aerosol size distribution measurements between 5 nm and 20 ìm were made during grinding on steel, aluminum, polytetrafluoroethylene, granite, ceramic tile and hardwood. Distributions were weighted by alveolar deposition probability to provide an indication of potential dose against metrics of number, surface area and volume. In all cases, the number-weighted size distributions showed most particles to lie in the ultrafine particle range (diameter <100 nm). Surface area-weighted distributions show substrates susceptible to thermal aerosol formation to be dominated by ultrafine particles. Weighting measurements by particle volume led to distributions dominated by particles >1 ìm, although aluminum, hardwood and steel all show substantial volume-fractions in the ultrafine region. There was evidence that the grinding tool contributed to the measured ultrafine aerosol fraction. Further work is required to isolate particle sources during similar operations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - exposure metrics
KW - grinding
KW - ultrafine aerosol
N1 - Accession Number: 109118879; MAYNARD, A. D. 1; ZIMMER, A. T. 1; Affiliations: 1: National Institute of Occupational Safety and Health, Cincinnati, OH, USA; Issue Info: 2002 Supplement, Vol. 46, p315; Author-Supplied Keyword: exposure metrics; Author-Supplied Keyword: grinding; Author-Supplied Keyword: ultrafine aerosol; Number of Pages: 5p; Document Type: Article
L3 - 10.1093/annhyg/mef654
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DB - eih
ER -
TY - JOUR
AU - KUEMPEL, E. D.
AU - TRAN, C. L.
T1 - Comparison of Human Lung Dosimetry Models: Implications for Risk Assessment.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/03/02/2002 Supplement
VL - 46
M3 - Article
SP - 337
EP - 341
SN - 00034878
AB - In this study we have compared several human lung dosimetry models and predicted particle burdens in the lungs and lymph nodes of humans with working lifetime exposures to airborne particulates. The focus of this study was the clearance and retention of poorly soluble particles in the alveolar (gas exchange) region of the lungs. The models evaluated include those developed for exposure to radioactive particles and coal mine dust and a rat-based overload model extrapolated to humans. Results show that the predicted mean particle burden in the lungs varies by as much as two orders of magnitude among the different models. These findings indicate that risk estimates for particle-related lung diseases in humans could differ considerably depending on the choice of lung dosimetry model. Further evaluation is needed to investigate which kinetic model features best predict human lung particle burdens over a range of particle sizes, types and exposure levels and to investigate issues of variability and uncertainty. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - dosimetry models
KW - lung burden
KW - particles
KW - risk assessment
KW - toxicokinetics
N1 - Accession Number: 109118885; KUEMPEL, E. D. 1; Email Address: ekuempel@cdc.gov; TRAN, C. L. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Risk Evaluation Branch, 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226-1998, USA; 2: Institute of Occupational Medicine, 8 Roxburgh Place, Edinburgh EH8 9SU, UK; Issue Info: 2002 Supplement, Vol. 46, p337; Author-Supplied Keyword: dosimetry models; Author-Supplied Keyword: lung burden; Author-Supplied Keyword: particles; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: toxicokinetics; Number of Pages: 5p; Document Type: Article
L3 - 10.1093/annhyg/mef665
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MAYNARD, A. D.
AU - MAYNARD, R. L.
T1 - Ambient Aerosol Exposure-Response as a Function of Particulate Surface Area: Reinterpretation of Historical Data Using Numerical Modelling.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/03/02/2002 Supplement
VL - 46
M3 - Article
SP - 444
EP - 449
SN - 00034878
AB - It has been hypothesized that the curvilinear response between British Smoke (BS) and excess mortality in London between 1958 and 1972 may be attributable to a linear response with respect to particulate number or surface area concentration. A numerical model has been developed and used to derive relationships between aerosol number, surface area and mass concentration under idealized environmental conditions. Modelling demonstrates that for a constant aerosol generation rate and rapid mixing, generalized functions can be derived that describe particle number versus mass concentration, and surface area versus mass concentration. The results indicate that the epidemiology data do not support a linear association between particle number concentration and mortality rate. However, a transformation between BS and particulate surface area is presented that leads to a linear association between aerosol surface area concentration and mortality rate. A critical mass concentration is defined, below which aerosol surface area varies linearly with mass. Above the critical mass concentration, numerical modelling supports the hypothesis that aerosol surface area is a more appropriate indicator of health effects associated with exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - aerosol surface area
KW - environmental exposure
KW - exposure metrics
KW - numerical modelling
N1 - Accession Number: 109118912; MAYNARD, A. D. 1; Email Address: amaynard@cdc.gov; MAYNARD, R. L. 2; Affiliations: 1: National Institute of Occupational Safety and Health, Cincinnati, OH, USA; 2: Department of Health, London, UK; Issue Info: 2002 Supplement, Vol. 46, p444; Author-Supplied Keyword: aerosol surface area; Author-Supplied Keyword: environmental exposure; Author-Supplied Keyword: exposure metrics; Author-Supplied Keyword: numerical modelling; Number of Pages: 6p; Document Type: Article
L3 - 10.1093/annhyg/mef715
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DB - eih
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chang, Cheng-Nan
AU - Wu, Yuh-Shen
AU - Lu, Shin-Chung
AU - Pi-Cheng Fu, Peter
AU - Chang, Shyh-Chyi
AU - Cheng, Chii-Dong
AU - Yuen, Win-Hsiao
T1 - Concentration of atmospheric particulates during a dust storm period in central Taiwan, Taichung
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2002/03/15/
VL - 287
IS - 1/2
M3 - Article
SP - 141
SN - 00489697
AB - In this study we monitored concentrations of particles in central Taiwan using PS-1 (GPS1 PUF Sampler) and Model 310 Universal Air Sampler™ (UASTM) from 02/23/2001 to 03/12/2001 at two sampling sites. During this period, an Asian dust storm moved across central Taiwan from 3/3 to 3/6. The total ambient air particle concentrations during the dust storm period were than compared with previous data from this region. In general, the average total suspended particulate (TSP) concentration order was during dust storm period>after dust storm period>non-dust storm period at both HKITT (traffic) and THUC (rural) sampling sites. The ratio of PM2.5/PM10 was 60% before and after the dust storm period. However, this ratio was decreased to less than 50% during the dust storm. This demonstrates that the coarse particulate concentrations (PM2.5–10) increased during the dust storm period. In contrast the increase of ambient air particles concentrations after the Taiwan Chi-Chi Earthquake were mainly due to fine particles (PM2.5). And, the increased of ambient air particles concentrations after dust storm period were mainly coarse particle (PM2.5–10) concentrations in central Taiwan. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Air quality
KW - Dust-storm
KW - Fugitive dust
KW - Particulate matter
KW - PM2.5–10
KW - PM2.5
KW - Total suspended particulate
N1 - Accession Number: 7753557; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw; Chang, Cheng-Nan 2; Wu, Yuh-Shen 1; Lu, Shin-Chung 1; Pi-Cheng Fu, Peter 3; Chang, Shyh-Chyi 2; Cheng, Chii-Dong 2; Yuen, Win-Hsiao 4; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang Institute of Technology, Sha-Lu, Taichung 433, Taiwan, ROC; 2: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan, ROC; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AK 72079, USA; 4: Department of Chemical Engineering, Hsiuping Institute of Technology, Taichung 412, Taiwan, ROC; Issue Info: Mar2002, Vol. 287 Issue 1/2, p141; Thesaurus Term: Air pollution; Thesaurus Term: Air quality; Author-Supplied Keyword: Dust-storm; Author-Supplied Keyword: Fugitive dust; Author-Supplied Keyword: Particulate matter; Author-Supplied Keyword: PM2.5–10; Author-Supplied Keyword: PM2.5; Author-Supplied Keyword: Total suspended particulate; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106963327
T1 - Aseptic meningitis associated with rofecoxib.
AU - Bonnel RA
AU - Villalba ML
AU - Karwoski CB
AU - Beitz J
Y1 - 2002/03/25/
N1 - Accession Number: 106963327. Language: English. Entry Date: 20020927. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Cox-2 Inhibitors -- Adverse Effects
KW - Meningitis -- Etiology
KW - Cox-2 Inhibitors -- Therapeutic Use
KW - Adult
KW - Aged
KW - Female
KW - Male
SP - 713
EP - 715
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 162
IS - 6
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Office of Postmarketing Drug Risk Assessment, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Ln, Room 15B-23, HFD-430, Rockville, MD 20857; bonnelr@cder.fda.gov
U2 - PMID: 11911727.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - SMUTZ, W. P.
AU - DONG, R. G.
AU - HAN, B.
AU - SCHOPPER, A. W.
AU - WELCOME, D. E.
AU - KASHON, M. L.
T1 - A Method for Reducing Adaptor Misalignment when Testing Gloves Using ISO 10819.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/04//
VL - 46
IS - 3
M3 - Article
SP - 309
EP - 315
SN - 00034878
AB - Objectives: International standard ISO 10819 was established in order to quantify the vibration attenuation characteristics of anti-vibration gloves. One problem that exists with the standard is possible misalignment of the palm adaptor that is placed underneath the test glove. If the adaptor becomes misaligned, the measured glove transmissibility will be lower than the actual value. A tri-axial accelerometer was installed in the adaptor and was used as the basis for providing visual feedback of the adaptor alignment to the test subjects. The objective of this study was to test the hypothesis that adaptor misalignment could be reduced by providing feedback to the test subjects. Methods: Eight male volunteers (mean age 24.8 yr) were used in the study. Each subject performed two sets of tests: the standard ISO 10819 glove test and the modified version. Three different anti-vibration gloves were tested. Glove transmissibility and adaptor misalignment were calculated for each glove. A three-way analysis of variance was used to analyze the results. Results: A comparison of the two testing methods showed that the modified glove testing method did reduce misalignment significantly, which, in turn, resulted in an increase in the measured glove transmissibility. Conclusions: The proposed method greatly improved the standard deviation of transmissibility and made the test results more consistent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Experimental design
KW - Industrial hygiene
KW - Industrial safety
KW - Work clothes
KW - Hypothesis
KW - Regression analysis
KW - Gloves
KW - Vibration (Mechanics)
KW - glove testing
KW - vibration
KW - vibration exposure
KW - International Organization for Standardization
N1 - Accession Number: 45225917; SMUTZ, W. P. 1; Email Address: wsmutz@cdc.gov; DONG, R. G. 1; HAN, B. 1; SCHOPPER, A. W. 1; WELCOME, D. E. 1; KASHON, M. L. 1; Affiliations: 1: Engineering and Control Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.; Issue Info: Apr2002, Vol. 46 Issue 3, p309; Thesaurus Term: Experimental design; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Subject Term: Work clothes; Subject Term: Hypothesis; Subject Term: Regression analysis; Subject Term: Gloves; Subject Term: Vibration (Mechanics); Author-Supplied Keyword: glove testing; Author-Supplied Keyword: vibration; Author-Supplied Keyword: vibration exposure ; Company/Entity: International Organization for Standardization; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 448199 All other clothing stores; NAICS/Industry Codes: 812332 Industrial Launderers; NAICS/Industry Codes: 315249 Women's and girls' cut and sew clothing manufacturing; NAICS/Industry Codes: 315220 Men's and Boys' Cut and Sew Apparel Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Biagini, R. E.
AU - Murphy, D. M.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - Striley, C. A. F.
AU - MacKenzie, B. A.
T1 - Development of Multiplexed Fluorescence Microbead Covalent Assays (FMCAs) for Pesticide Biomonitoring.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 2002/04//
VL - 68
IS - 4
M3 - Article
SP - 470
EP - 477
PB - Springer Science & Business Media B.V.
SN - 00074861
AB - This article focuses on the development of multiplexed fluorescence microbead covalent assays. Atrazine and metolachlor are widely used herbicides in the U.S. for pre-emergence control of broad-leaf weeds. Quantitative analyses for urinary excreted pesticides or pesticide metabolites are classically performed by instrumental analysis after separation from a urine matrix, This procedure is costly, time consuming, labor intensive and requires the acquisition of high capital expenditure equipment and highly trained personnel, although it is usually highly specific.
KW - Pesticides
KW - Assaying
KW - Gardening
KW - Biological monitoring
KW - Urine
KW - Body fluids
N1 - Accession Number: 15245404; Biagini, R. E. 1; Murphy, D. M. 1; Sammons, D. L. 1; Smith, J. P. 1; Striley, C. A. F. 1; MacKenzie, B. A. 1; Affiliations: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: Apr2002, Vol. 68 Issue 4, p470; Thesaurus Term: Pesticides; Thesaurus Term: Assaying; Thesaurus Term: Gardening; Thesaurus Term: Biological monitoring; Subject Term: Urine; Subject Term: Body fluids; NAICS/Industry Codes: 561730 Landscaping Services; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/S001128-001-0278-5
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DB - eih
ER -
TY - JOUR
AU - Sutherland, M. F.
AU - Drew, A.
AU - Rolland, J. M.
AU - Slater, J. E.
AU - Suphioglu, C.
AU - O'Hehir, R. E.
T1 - Specific monoclonal antibodies and human immunoglobulin E show that Hev b 5 is an abundant allergen in high protein powdered latex gloves.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2002/04//
VL - 32
IS - 4
M3 - Article
SP - 583
EP - 589
PB - Wiley-Blackwell
SN - 09547894
AB - Summary Background Hev b 5 is a major latex allergen recognized predominantly by latex-allergic health care workers (HCWs). Recombinant Hev b 5 (rHev b 5) was previously expressed as a fusion protein with maltose binding protein (MBP), itself an immunogenic molecule; therefore non-fusion rHev b 5 is desirable. Moreover, standardized immunological assays for the detection of Hev b 5 are currently lacking and may have important implications for both allergen avoidance and diagnosis in latex allergy. Objectives To generate and use Hev b 5-specific mAbs to determine the relative abundance of Hev b 5 in different latex extracts, correlating this with the IgE reactivity of latex-allergic HCWs and to produce non-fusion rHev b 5. Methods For the production of mAbs, mice were immunized with rHev b 5/MBP fusion protein and mAbs selected with rHev b 5/MBP but not MBP reactivity. The mAb reactivity was compared with polyclonal IgE from latex-allergic HCWs using direct and inhibition ELISA and immunoblot assays. Recombinant Hev b 5 was expressed and purified in the pPROEX-HTa bacterial expression system. Results Four Hev b 5-specific mAbs were produced. Immunoblotting and ELISA using the mAbs indicate abundant Hev b 5 in high protein powdered latex glove extracts as compared with crude latex sap extracts. High quality surgical gloves with no detectable protein have no detectable Hev b 5. Inhibition ELISAs using serum IgE from latex-allergic HCWs and Hev b 5-specific mAbs gave strong correlation. Non-fusion recombinant Hev b 5 was successfully expressed and purified, showing reactivity with both the Hev b 5-specific mAbs and serum IgE of latex-allergic HCWs. Conclusion Hev b 5-specific mAbs and human IgE from latex-allergic HCWs demonstrate the greater content of Hev b 5 in high protein powdered glove extracts. This may explain the observed higher frequency of sensitization to this allergen in HCWs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Latex
KW - Monoclonal antibodies
KW - Hev b 5
KW - latex allergy
KW - latex gloves
KW - monoclonal antibodies
KW - recombinant proteins
N1 - Accession Number: 6542280; Sutherland, M. F. 1,2; Drew, A. 1,2; Rolland, J. M. 2,3; Slater, J. E. 4; Suphioglu, C. 1,2; O'Hehir, R. E. 1,2; Affiliations: 1: Allergy, Asthma and Clinical Immunology, and; 2: Co-operative Research Centre for Asthma, Sydney, Australia; and the; 3: Pathology and Immunology, The Alfred Hospital and Monash University, Victoria,; 4: Laboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA; Issue Info: Apr2002, Vol. 32 Issue 4, p583; Thesaurus Term: Allergy; Subject Term: Latex; Subject Term: Monoclonal antibodies; Author-Supplied Keyword: Hev b 5; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: latex gloves; Author-Supplied Keyword: monoclonal antibodies; Author-Supplied Keyword: recombinant proteins; Number of Pages: 0p; Illustrations: 5 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.0954-7894.2002.01355.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PETTIFORD, J. N
AU - JASON, J
AU - NWANYANWU, O. C
AU - ARCHIBALD, L. K
AU - KAZEMBE, P. N
AU - DOBBIE, H
AU - JARVIS, W. R
T1 - Age-related differences in cell-specific cytokine production by acutely ill Malawian patients*.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2002/04//
VL - 128
IS - 1
M3 - Article
SP - 110
EP - 117
SN - 00099104
AB - SUMMARY Age-related changes in human cell-specific cytokine responses to acute illness have not been well examined. We therefore evaluated age-related differences in T, B and natural killer (NK) peripheral blood lymphocyte cytokine responses of 309 acutely ill hospitalized people in Malawi, Africa, <1 month–61 years of age. We used four-colour flow cytometry and performed Wilcoxon rank sum and Kruskal–Wallis tests, Pearson (r p ) and Spearman (r s ) correlations, and linear and logistic regression analyses to control for human immunodeficiency virus infection (HIV) status, the percentages of lymphocytes expressing CD4, and the nature of the acute infection. The percentages of CD8- and CD8+ T cells producing induced IL-8 decreased with age (r s = -0·44 and -0·53). The percentages of T cells producing TNF-α were higher, and the percentages producing IL-10 were lower, in those ≥13 than those <13 years old (medians: 17·7 versus 10·5 and 1·4 versus 3·0, respectively). The percentages of CD8- T cells producing IFN-γ were higher and stable in those ≥1 year old compared to infants (medians: 23·5 versus 10·4); the percentages of NK producing IFN-γ were higher post-infancy and then declined to relatively low levels with increasing age. The percentages of T cells producing IL-2 were highest in those 5–<31 years old (median 5·6) and lowest in those ≥31 years old (median 1·9). The ratios of the percentages of T cells producing IL-4 to those producing IL-8 and to those producing IL-10 both increased with age. These data suggest that innate immunity, represented by NK IFN-γ production, dominates in early life. A number of shifts occur after infancy and before adolescence, including a proinflammatory shift from IL-8 to TNF-γ and a type 2 shift from IL-10 to IL-4 dominance. These findings suggest... [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - DISEASES
KW - LYMPHOCYTES -- Aging
KW - IMMUNOLOGY
KW - age
KW - cytokine balance
KW - IFN-γ IL-8 immunosenescence T lymphocytes
N1 - Accession Number: 6573761; PETTIFORD, J. N 1; JASON, J 1; NWANYANWU, O. C 2; ARCHIBALD, L. K 3; KAZEMBE, P. N 4; DOBBIE, H 4; JARVIS, W. R 3; Source Information: Apr2002, Vol. 128 Issue 1, p110; Subject: CYTOKINES; Subject: DISEASES; Subject: LYMPHOCYTES -- Aging; Subject: IMMUNOLOGY; Author-Supplied Keyword: age; Author-Supplied Keyword: cytokine balance; Author-Supplied Keyword: IFN-γ IL-8 immunosenescence T lymphocytes; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1365-2249.2002.01813.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Szarfman, A.
AU - Machado, S.G.
AU - O'Neill, R.T.
T1 - Use of Screening Algorithms and Computer Systems to Efficiently Signal Higher-Than-Expected Combinations of Drugs and Events in the US FDA's Spontaneous Reports Database.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/04//
VL - 25
IS - 6
M3 - Article
SP - 381
EP - 392
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Since 1998, the US Food and Drug Administration (FDA) has been exploring new automated and rapid Bayesian data mining techniques. These techniques have been used to systematically screen the FDA's huge MedWatch database of voluntary reports of adverse drug events for possible events of concern. The data mining method currently being used is the Multi-Item Gamma Poisson Shrinker (MGPS) program that replaced the Gamma Poisson Shrinker (GPS) program we originally used with the legacy database. The MGPS algorithm, the technical aspects of which are summarised in this paper, computes signal scores for pairs, and for higher-order (e.g. triplet, quadruplet) combinations of drugs and events that are significantly more frequent than their pair-wise associations would predict. MGPS generates consistent, redundant, and replicable signals while minimising random patterns. Signals are generated without using external exposure data, adverse event background information, or medical information on adverse drug reactions. The MGPS interface streamlines multiple input-output processes that previously had been manually integrated. The system, however, cannot distinguish between already-known associations and new associations, so the reviewers must filter these events. In addition to detecting possible serious single-drug adverse event problems, MGPS is currently being evaluated to detect possible synergistic interactions between drugs (drug interactions) and adverse events (syndromes), and to detect differences among subgroups defined by gender and by age, such as paediatrics and geriatrics. In the current data, only 3.4% of all 1.2 million drug-event pairs ever reported (with frequencies ≥1) generate signals [lower 95% confidence interval limit of the adjusted ratios of the observed counts over expected (O/E) counts (denoted EB05) of ≥2]. The total frequency count that contributed to signals comprised 23% (2.4 million) of the total number, 10.4 million of drug-event pairs reported, greatly facilitating a more focused follow-up and evaluation. The algorithm provides an objective, systematic view of the data alerting reviewers to critically important, new safety signals. The study of signals detected by current methods, signals stored in the Center for Drug Evaluation and Research's Monitoring Adverse Reports Tracking System, and the signals regarding cerivastatin, a cholesterol-lowering drug voluntarily withdrawn from the market in August 2001, exemplify the potential of data mining to improve early signal detection. The operating characteristics of data mining in detecting early safety signals, exemplified by studying a drug recently well characterised by large clinical trials confirms our experience that the signals generated by data mining have high enough specificity to deserve further investigation. The application of these tools may ultimately improve usage recommendations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs
KW - Data mining
KW - Bayesian analysis
KW - United States
KW - Adverse reaction monitoring
KW - Electronic information services
N1 - Accession Number: 6911734; Szarfman, A. 1; Machado, S.G. 1; O'Neill, R.T. 1; Affiliations: 1: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Apr2002, Vol. 25 Issue 6, p381; Thesaurus Term: Drugs; Subject Term: Data mining; Subject Term: Bayesian analysis; Subject: United States; Author-Supplied Keyword: Adverse reaction monitoring; Author-Supplied Keyword: Electronic information services; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Palmai, M.
AU - Buchanan, R. L.
T1 - Growth of Listeria monocytogenes during germination of alfalfa sprouts
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/04//
VL - 19
IS - 2/3
M3 - Article
SP - 195
SN - 07400020
AB - A large number of micro-organisms are able to proliferate on sprouts. The microflora may occasionally contain pathogenic bacteria that can be a source of outbreaks. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic microorganisms
KW - Sprouts
N1 - Accession Number: 7923072; Palmai, M. 1; Buchanan, R. L. 2; Affiliations: 1: Campden and Chorleywood Food Industry Development Institute, Hungary; 2: US Food and Drug Administration, Center for Food Safety and Nutrition, FSI, 200 C Street, SW, Washington, DC, 20204, USA; Issue Info: Apr2002, Vol. 19 Issue 2/3, p195; Thesaurus Term: Pathogenic microorganisms; Subject Term: Sprouts; Number of Pages: 6p; Document Type: Article
L3 - 10.1006/fmic.2001.0470
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106972307
T1 - Policy and politics. Minority health disparities: AHRQ efforts to address inequities in care.
AU - Stryer D
AU - Clancy C
AU - Simpson L
Y1 - 2002/04//
N1 - Accession Number: 106972307. Language: English. Entry Date: 20021025. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 100890609.
KW - Minority Groups
KW - Health Status
KW - Health Services Accessibility
KW - Socioeconomic Factors
KW - Quality of Health Care
KW - Health Services Research
KW - Health Care Delivery
KW - United States Agency for Healthcare Research and Quality
KW - Medically Underserved
KW - Health and Welfare Planning
SP - 125
EP - 129
JO - Health Promotion Practice
JF - Health Promotion Practice
JA - HEALTH PROMOT PRACT
VL - 3
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1524-8399
AD - Physician Researcher, Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106920947
T1 - The Medicaid managed care grievance process: new protections for beneficiaries.
AU - Brady TS
AU - Hutchison S
Y1 - 2002/04//
N1 - Accession Number: 106920947. Language: English. Entry Date: 20020503. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 8215859.
KW - Medicare
KW - Patient Rights
KW - United States
SP - 46
EP - 51
JO - hfm (Healthcare Financial Management)
JF - hfm (Healthcare Financial Management)
JA - HEALTHC FINANC MANAGE
VL - 56
IS - 4
CY - Westchester, Illinois
PB - Healthcare Financial Management Association
AB - The Centers for Medicare and Medicaid Services (CMS) recently proposed regulations to enhance protection of the rights of Medicaid managed care enrollees to appeal decisions made by their managed care plans. The regulations would require both internal and external beneficiary grievance processes that could have a significant effect on managed care organizations with multiple lines of business operating in several states. Managed care organizations may find it worthwhile to develop a standard grievance process that meets Medicaid and Medicare requirements and can be used by enrollees in commercial plans. In addition to saving money and reducing confusion, a well-structured internal grievance process for all product lines would be useful as part of a quality-improvement initiative. Data from grievances may provide information that can help healthcare providers update medical protocols.
SN - 0735-0732
AD - Office of Inspector General, US Department of Health and Human Services, San Francisco,California
U2 - PMID: 11963598.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wasserman, Donald E.
AU - Hudock, Stephen D.
AU - Wasserman, Jack F.
AU - Mullinix, Logan
AU - Wurzelbacher, Steven J.
AU - Siegfried, Karl V.
T1 - Hand–arm vibration in a group of hand-operated grinding tools.
JO - Human Factors & Ergonomics in Manufacturing
JF - Human Factors & Ergonomics in Manufacturing
Y1 - 2002///Spring2002
VL - 12
IS - 2
M3 - Article
SP - 211
EP - 226
SN - 10908471
AB - Vibration acceleration was triaxially and basicentrically measured, and digital-audio-tape-recorded with each axis separately evaluated using both the ANSI S3.34 and ACGIH hand-arm vibration (HAV) guidelines, for two pairs of pneumatic handheld grinders commonly used in metal fabrication operations including shipyards. Each tool pair consisted of a new and used grinder of the same model, performing the same simulated grinding tasks using new small grinding wheels, carbide burrs, wire brushes, and flap wheels. The results of this limited study showed, primarily, that the HAV standards were not exceeded, but there was a consistent tendency for the acceleration levels to increase between new and used tools, ranging from 11% to 66% on the Z-axis, 13% to 66% on the Y-axis, 44% to 58% on the X-axis, when tasks involved using grinding wheels and carbide burrs (hard implements). The results were mixed when using disposable wire brushes and flap wheels (softer implements). The overall results suggest the need for and implementation of a regular tool vibration monitoring and maintenance program as a primary element to help maintain tool acceleration levels to a minimum. © 2002 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors & Ergonomics in Manufacturing is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ergonomics
KW - Vibration (Mechanics)
KW - Grinding machines
KW - Oscillations
KW - Tools
N1 - Accession Number: 13361391; Wasserman, Donald E. 1; Hudock, Stephen D. 2; Wasserman, Jack F. 1; Mullinix, Logan 1; Wurzelbacher, Steven J. 2; Siegfried, Karl V. 3; Affiliations: 1: Institute for the Study of Human Vibration, University of Tennessee Engineering School, Knoxville, TN 37996-2030, U.S.A.; 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, U.S.A.; 3: MEMIC Safety Services, Portland, ME 04104, U.S.A.; Issue Info: Spring2002, Vol. 12 Issue 2, p211; Subject Term: Ergonomics; Subject Term: Vibration (Mechanics); Subject Term: Grinding machines; Subject Term: Oscillations; Subject Term: Tools; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; Number of Pages: 16p; Illustrations: 2 Black and White Photographs, 3 Diagrams, 8 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/hfm.10009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Ye, Jianping
AU - Ma, Jane
AU - Barger, Mark
AU - Robinson, Victor A.
AU - Ramsey, Dawn
AU - McLaurin, Jeff
AU - Khan, Amir
AU - Landsittel, Douglas
AU - Teass, Alexander
AU - Castranova, Vincent
T1 - TIME COURSE OF PULMONARY RESPONSE OF RATS TO INHALATION OF CRYSTALLINE SILICA: NF-κB ACTIVATION, INFLAMMATION, CYTOKINE PRODUCTION, AND DAMAGE.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2002/04//
VL - 14
IS - 4
M3 - Article
SP - 349
EP - 367
SN - 08958378
AB - In vitro studies suggest that silica-induced lung disease may be linked to processes regulated by nuclear factor-κB (NF-κB) activation, but this has not been examined in vivo. Rats were exposed to a silica aerosol of 15 mg/m[sup 3] (6 h/day, 5 days/wk) for 116 days, and bronchoalveolar lavage (BAL) was conducted at various times during the exposure. Silica-induced pulmonary inflammation and damage were determined by measuring BAL cell differentials and first BAL fluid lactate dehydrogenase (LDH) activity and serum albumin concentrations, respectively. NF-κB activation and production of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) by BAL cells were also measured. The results demonstrate that NF-κB activation occurred after 5 days exposure, and continued to increase thereafter. BAL cell production of IL-1 and TNF-α had increased incrementally by 10 and 30 days of exposure, respectively. This elevation continued through 79 days of exposure before further increasing at 116 days of exposure. Pulmonary inflammation and damage in silica-exposed rats were also significantly elevated at 5 days of exposure, further increased at a slow rate through 41 days of exposure, and dramatically increased thereafter. Taken together, the results indicate that the initial molecular response of NF-κB activation in BAL cells occurs in response to low levels of silica deposition in the lung and increases more rapidly versus exposure duration than silica-induced pulmonary inflammation, cellular damage, and cytokine production by BAL cells. This suggests that NF-κB activation in BAL cells may play an important role in the initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lung diseases
KW - Inflammation
KW - Bronchoalveolar lavage
N1 - Accession Number: 6476276; Porter, Dale W. 1; Ye, Jianping 1; Ma, Jane 1; Barger, Mark 1; Robinson, Victor A. 1; Ramsey, Dawn 2; McLaurin, Jeff 2; Khan, Amir 2; Landsittel, Douglas 1; Teass, Alexander 2; Castranova, Vincent 1; Affiliations: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA; 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio, USA; Issue Info: Apr2002, Vol. 14 Issue 4, p349; Subject Term: Lung diseases; Subject Term: Inflammation; Subject Term: Bronchoalveolar lavage; Number of Pages: 19p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/08958370252870998
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106945857
T1 - From the Food and Drug Administration. MedSun: user facility reporting for the new millennium.
AU - Rich S
Y1 - 2002/04//2002 Apr-Jun
N1 - Accession Number: 106945857. Language: English. Entry Date: 20020809. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Product Surveillance
KW - United States Food and Drug Administration
KW - Product Surveillance -- History
KW - Voluntary Reporting
KW - Mandatory Reporting
KW - United States
SP - 57
EP - 58
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 8
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Supervisory Nurse Consultant, Center for Devices and Radiological Health, Food and Drug Administration; ser@cdrh.fda.gov
U2 - PMID: 12000910.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106926147
T1 - The development and role of predictive instruments in acute coronary events: improving diagnosis and management.
AU - Stryer DB
Y1 - 2002/04//
N1 - Accession Number: 106926147. Language: English. Entry Date: 20020531. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8703516.
KW - Myocardial Infarction -- Diagnosis
KW - Angina, Unstable -- Diagnosis
KW - Decision Support Systems, Clinical
KW - Triage
KW - Decision Making, Clinical
KW - Emergency Care
KW - Diagnostic Reasoning
KW - Quality Improvement
KW - Instrument Construction
KW - Instrument Validation
KW - Clinical Trials
SP - 1
EP - 8
JO - Journal of Cardiovascular Nursing
JF - Journal of Cardiovascular Nursing
JA - J CARDIOVASC NURS
VL - 16
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The diagnosis and management of acute myocardial infarction and unstable angina pectoris are frequent challenges for emergency department staff. Strategies must quickly and accurately identify all patients requiring admission, monitoring, and reperfusion therapy to maximize outcomes without overdiagnosing. The Acute Cardiac Ischemia Time-Insensitive Predictive Instrument and the Thrombolytic Predictive Instrument are two decision-support tools designed to address this need. The instruments have been shown to improve some measures of the appropriateness of and time to emergency department triage. Prospective trials will be completed soon that will examine their effects on morbidity and mortality. Copyright © 2002 by Aspen Publishers, Inc.
SN - 0889-4655
AD - Physician Researcher, Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 11958440.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106974715
T1 - A public health approach to the needs of children affected by terrorism.
AU - Baker DR
Y1 - 2002///2002 Spring
N1 - Accession Number: 106974715. Language: English. Entry Date: 20021101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503064.
KW - Terrorism
KW - Public Health
KW - Stress Disorders, Post-Traumatic -- Etiology
KW - Child Welfare
KW - Child, Preschool
KW - Child
KW - Child Health Services
KW - Substance Abuse -- Prevention and Control
KW - Mental Disorders -- Prevention and Control
SP - 117
EP - 118
JO - Journal of the American Medical Women's Association
JF - Journal of the American Medical Women's Association
JA - J AM MED WOMENS ASSOC
VL - 57
IS - 2
CY - Reston, Virginia
PB - American Medical Women's Association
AB - The devastating terrorist incidents of Pan Am Flight 103, the Oklahoma City bombing, the bombings of the embassies in Kenya and Tanzania, and the World Trade Center attack of September 11, 2001, have forever changed America. These terrorist acts have deeply shaken the sense of safety, security, and well-being of our surviving children and families. These terrorist acts may also have increased the public health risks of substance abuse and mental illness for our children. The Substance Abuse and Mental Health Services Administration is responsible for strengthening prevention and treatment of substance abuse and mental illness in children and families. America's children may exhibit a wide range of emotional, physical, and psychological reactions following natural and man-made disasters. Largescale disasters witnessed by children all underscore the need for a broad mental health and substance abuse public health approach. This approach is critical for our children's well-being.
SN - 0098-8421
AD - Senior Public Health Analyst, Substance Abuse and Mental Health Services Administration, Rockville, MD
U2 - PMID: 11991421.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106974715&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brown, S. Lori
AU - Pennello, Gene
T1 - Replacement Surgery and Silicone Gel Breast Implant Rupture: Self-Report by Women after Mammoplasty.
JO - Journal of Women's Health & Gender-Based Medicine
JF - Journal of Women's Health & Gender-Based Medicine
Y1 - 2002/04//
VL - 11
IS - 3
M3 - Article
SP - 255
EP - 264
PB - Mary Ann Liebert, Inc.
SN - 15246094
AB - Background: This study examined the prevalence of revision surgery in which silicone gel breast implants were either removed (explanted) or replaced in a cohort of women from Birmingham, Alabama. The main reason leading up to the surgery and the prevalence of ruptured implants reported after explantation are described. Methods: Data were collected from telephone interviews with 907 women previously identified in a larger cohort study of women with breast implants. Women who reported breast surgeries subsequent to their index mammoplasty were asked to consent to retrieval of the surgical records describing the surgery. Results: Surgery in which a silicone gel breast implant was removed or replaced was reported by 33% of the 907 women in this cohort. The most common reason for surgery was problems with the implant that affected the breast (103 of 303 surgeries). Of the 303 women reporting surgery, 145 (48%) reported knowing after a surgery that an implant was ruptured when it was removed, and 171 (56%) reported knowing that an implant was ruptured or leaking. Overall, 16% of the 907 women reported knowing that either of their implants was ruptured after any surgery. At least one surgical record was retrieved for 165 (54%) of the 303 women reporting surgery. Among these women, the rupture rate was 69 of 165 (42%) according to the surgical record and 85 of 165 (51.5%) according to self-reports, a statistically significant difference (p = 0.008 from McNemar's test). The mean time from implantation to surgery was 11.5 years among women reporting surgery and estimated at 21.4 years for all women. Conclusions: A third of the women in this cohort underwent additional surgery after the initial mammoplasty, and nearly half who underwent surgery reported that their implants were found to be ruptured when removed. Women considering silicone gel breast implants should be informed of the risk of additional surgeries and of the potential risk of breast implant rupture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health & Gender-Based Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST implants
KW - MAMMAPLASTY
KW - SURGERY
KW - ARTIFICIAL implants
KW - SILICONES in surgery
KW - PLASTIC surgery
N1 - Accession Number: 6590432; Brown, S. Lori 1; Pennello, Gene 2; Source Information: Apr2002, Vol. 11 Issue 3, p255; Subject: BREAST implants; Subject: MAMMAPLASTY; Subject: SURGERY; Subject: ARTIFICIAL implants; Subject: SILICONES in surgery; Subject: PLASTIC surgery; Number of Pages: 10p; Document Type: Article
L3 - 10.1089/152460902753668457
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=6590432&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106985839
T1 - Replacement surgery and silicone gel breast implant rupture: self-report by women after mammoplasty.
AU - Brown SL
AU - Pennello G
Y1 - 2002/04//
N1 - Accession Number: 106985839. Language: English. Entry Date: 20021213. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 100888719.
KW - Silicones
KW - Postoperative Complications
KW - Breast Implants
KW - Reoperation
KW - Female
KW - Alabama
KW - Middle Age
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Epidemiological Research
KW - Telephone
KW - Interviews
KW - Record Review
KW - Self Report
KW - Statistical Significance
KW - McNemar's Test
KW - Descriptive Statistics
KW - Prospective Studies
KW - Mail
KW - Questionnaires
KW - Research Subject Recruitment
KW - Kaplan-Meier Estimator
KW - Human
SP - 255
EP - 264
JO - Journal of Women's Health & Gender-Based Medicine
JF - Journal of Women's Health & Gender-Based Medicine
JA - J WOMENS HEALTH GENDER BASED MED
VL - 11
IS - 3
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - BACKGROUND: This study examined the prevalence of revision surgery in which silicone gel breast implants were either removed (explanted) or replaced in a cohort of women from Birmingham, Alabama. The main reason leading up to the surgery and the prevalence of ruptured implants reported after explantation are described. METHODS: Data were collected from telephone interviews with 907 women previously identified in a larger cohort study of women with breast implants. Women who reported breast surgeries subsequent to their index mammoplasty were asked to consent to retrieval of the surgical records describing the surgery. RESULTS: Surgery in which a silicone gel breast implant was removed or replaced was reported by 33% of the 907 women in this cohort. The most common reason for surgery was problems with the implant that affected the breast (103 of 303 surgeries). Of the 303 women reporting surgery, 145 (48%) reported knowing after a surgery that an implant was ruptured when it was removed, and 171 (56%) reported knowing that an implant was ruptured or leaking. Overall, 16% of the 907 women reported knowing that either of their implants was ruptured after any surgery. At least one surgical record was retrieved for 165 (54%) of the 303 women reporting surgery. Among these women, the rupture rate was 69 of 165 (42%) according to the surgical record and 85 of 165 (51.5%) according to self-reports, a statistically significant difference (p = 0.008 from McNemar's test). The mean time from implantation to surgery was 11.5 years among women reporting surgery and estimated at 21.4 years for all women. CONCLUSIONS: A third of the women in this cohort underwent additional surgery after the initial mammoplasty, and nearly half who underwent surgery reported that their implants were found to be ruptured when removed. Women considering silicone gel breast implants should be informed of the risk of additional surgeries and of the potential risk of breast implant rupture.
SN - 1524-6094
AD - Epidemiology Branch, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr, HFZ-51, Rockville, MD 20850
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Darnton-Hill, Ian
AU - Nalubola, Ritu
T1 - Fortification strategies to meet micronutrient needs: sucesses and failures.
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
Y1 - 2002/04//
VL - 61
IS - 2
M3 - Article
SP - 231
EP - 241
SN - 00296651
AB - Food fortification is likely to have played an important role in the current nutritional health and well-being of populations in industrialized countries. Starting in the early part of the 20th century, fortification was used to target specific health conditions: goitre with iodized salt; rickets with vitamin D-fortified milk; beriberi, pellagra and anaemia with B-vitamins and Fe-enriched cereals; more recently, in the USA, risk of pregnancy affected by neural-tube defects with folic acid-fortified cereals. A relative lack of appropriate centrally-processed food vehicles, less-developed commercial markets and relatively low consumer awareness and demand, means it has taken about another 50 years for fortification to be seen as a viable option for the less-developed countries. The present paper reviews selected fortification initiatives in developing countries to identify different factors that contributed to their successful implementation, as well as the challenges that continually threaten the future of the se programmes. Ultimately, the long-term sustainability of fortification programmes is ensured when consumers are willing and able to bear the additional cost of fortified foods. There has been an enormous increase in fortification programmes over the last couple of decades in developing countries. Considerable progress has been made in reducing vitamin A and I deficiencies, although less so with Fe, even as Zn and folic acid deficiencies are emerging as important public health problems. Food fortification based on sound principles and supported by clear policies and regulations can play an increasingly large role in this progress towards prevention and control of micronutrient malnutrition. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Proceedings of the Nutrition Society is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 56766121; Darnton-Hill, Ian 1; Nalubola, Ritu 2; Affiliations: 1: World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland; 2: US Food and Drug Administration, Washington, DC, USA; Issue Info: Apr2002, Vol. 61 Issue 2, p231; Number of Pages: 11p; Document Type: Article
L3 - 10.1079/PNS2002150
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hope, B. K.
AU - Baker, A. R.
AU - Edel, E. D.
AU - Hogue, A. T.
AU - Schlosser, W. D.
AU - Whiting, R.
AU - McDowell, R. M.
AU - Morales, R. A.
T1 - An Overview of the Salmonella Enteritidis Risk Assessment for Shell Eggs and Egg Products.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2002/04//
VL - 22
IS - 2
M3 - Article
SP - 203
EP - 218
PB - Wiley-Blackwell
SN - 02724332
AB - This article summarizes a quantitative microbial risk assessment designed to characterize the public health impact of consumption of shell eggs and egg products contaminated with Salmonella Enteritidis (SE). This risk assessment's objectives were to: (1) establish the baseline risk of foodborne illness from SE, (2) identify and evaluate potential risk mitigation strategies, and (3) identify data gaps related to future research efforts. The risk assessment model has five modules. The Egg Production module estimates the number of eggs produced that are SE-contaminated. Shell Egg Processing, Egg Products Processing, and Preparation & Consumption modules estimate the increase or decrease in the numbers of SE organisms in eggs or egg products as they pass through storage, transportation, processing, and preparation. A Public Health Outcomes module then calculates the incidence of illnesses and four clinical outcomes, as well as the cases of reactive arthritis associated with SE infection following consumption. The baseline model estimates an average production of 2.3 million SE-contaminated shell eggs/year of the estimated 69 billion produced annually and predicts an average of 661,633, human illnesses per year from consumption of these eggs. The model estimates ≈ 94% of these cases recover without medical care, 5% visit a physician, an additional 0.5% are hospitalized, and 0.05% result in death. The contribution of SE from commercially pasteurized egg products was estimated to be negligible. Five mitigation scenarios were selected for comparison of their individual and combined effects on the number of human illnesses. Results suggest that mitigation in only one segment of the farm-to-table continuum will be less effective than several applied in different segments. Key data gaps and areas for future research include the epidemiology of SE on farms, the bacteriology of SE in eggs, human behavior in food handling and preparation, and human... [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Public health
KW - Salmonella
KW - Diseases
KW - Consumption (Economics)
KW - Salmonella enteritidis
KW - human health
KW - Microbial risk assessment
KW - Probabilistic assessment
KW - shell eggs
N1 - Accession Number: 6650501; Hope, B. K. 1; Email Address: hope.bruce@deq.state.or.us; Baker, A. R. 1; Edel, E. D. 2; Hogue, A. T. 1; Schlosser, W. D. 3; Whiting, R. 4; McDowell, R. M. 5; Morales, R. A. 6; Affiliations: 1: U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, DC; 2: U.S. Department of Agriculture, Food Safety and Inspection Service, Ft. Collins, CO; 3: U.S. Department of Agriculture, Food Safety and Inspection Service, College Station, TX; 4: Food and Drug Administration, Center for Food Safety and Nutrition (CFSAN), Washington, DC; 5: U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Riverdale, MD; 6: Research Triangle Institute, Research Triangle Park, NC; Issue Info: Apr2002, Vol. 22 Issue 2, p203; Thesaurus Term: Risk assessment; Thesaurus Term: Public health; Thesaurus Term: Salmonella; Thesaurus Term: Diseases; Subject Term: Consumption (Economics); Subject Term: Salmonella enteritidis; Author-Supplied Keyword: human health; Author-Supplied Keyword: Microbial risk assessment; Author-Supplied Keyword: Probabilistic assessment; Author-Supplied Keyword: shell eggs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frasch, H. Frederick
T1 - A Random Walk Model of Skin Permeation.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2002/04//
VL - 22
IS - 2
M3 - Article
SP - 265
EP - 276
PB - Wiley-Blackwell
SN - 02724332
AB - A new mathematical model for permeability of chemicals in aqueous vehicle through skin is presented. The rationale for this model is to represent diffusion by its fundamental molecular mechanism, i.e., random thermal motion. Diffusion is modeled as a two-dimensional random walk through the biphasic (lipid and corneocyte) stratum corneum (SC). This approach permits calculations of diffusion phenomena in a morphologically realistic SC structure. Two concepts are key in the application of the model to the prediction of steady-state skin permeability coefficients: "effective diffusivity" and "effective path length," meaning the diffusivity and thickness of a homogeneous membrane having identical permeation properties as the stratum corneum. Algebraic expressions for these two variables are developed as functions of the molecular weight and octanol-water partition coefficient of the diffusing substance. Combining these with expressions for membrane-vehicle partition coefficient and permeability of the aqueous epidermis enables the calculation of steady-state skin permeability coefficients. The resulting four-parameter algebraic model was regressed against the "Flynn data base" with excellent results (R2 = 0.84; SE = 0.0076; F = 154; N = 94). The model provides insight into the contributions of stratum corneum diffusivity and effective path lengths to overall skin permeability and may prove useful in the prediction of non-steady-state diffusion phenomena. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mathematical models
KW - Permeability
KW - Diffusion
KW - Chemicals
KW - Algebra
N1 - Accession Number: 6650497; Frasch, H. Frederick 1; Email Address: hbf9@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 USA; Issue Info: Apr2002, Vol. 22 Issue 2, p265; Thesaurus Term: Mathematical models; Thesaurus Term: Permeability; Thesaurus Term: Diffusion; Subject Term: Chemicals; Subject Term: Algebra; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gadd, Samantha L.
AU - Hobbs, Gerry
AU - Miller, Michael R.
T1 - Acetaminophen-Induced Proliferation of Estrogen-Responsive Breast Cancer Cells Is Associated with Increases in c-myc RNA Expression and NF-κB Activity.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/04//
VL - 66
IS - 2
M3 - Article
SP - 233
EP - 243
PB - Oxford University Press / USA
SN - 10966080
AB - Studies reported here tested the hypothesis that acetaminophen stimulates proliferation of E2-responsive cells by inducing expression of E2-regulated genes. Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21CIP1/WAF1, and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells. Acetaminophen and E2 increased c-myc RNA levels in MCF-7 cells, consistent with a mitogenic activity of these compounds in MCF-7 cells. However, the magnitude and time course of acetaminophen and E2 induction of c-myc differed. Neither acetaminophen nor E2 induced c-myc in MDA-MB-231 cells, whereas E2, but not acetaminophen, weakly induced c-myc expression in Ishikawa cells. Furthermore, in these 3 cell types, the expression patterns of the other genes differed dramatically in response to acetaminophen and to E2, indicating that acetaminophen does not activate ER as a transcription factor in the same manner as does E2. Additionally, gel shift assays demonstrated that in MCF-7 cells, acetaminophen increased NF-κB activity ∼40% and did not alter AP-1 activity, whereas E2 increased AP-1 activity ∼50% and did not increase NF-B activity. These studies indicate that acetaminophen effects on gene expression and cell proliferation depend more on cell type/context than on the presence of ER. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acetaminophen
KW - Breast cancer
KW - Mitogens
KW - Gene expression
KW - Cell proliferation
KW - acetaminophen
KW - c-myc gene
KW - cell cycle
KW - estrogen receptor
KW - NF-κB
KW - NF-κB
N1 - Accession Number: 44406276; Gadd, Samantha L. 1; Hobbs, Gerry 2; Miller, Michael R. 1,3; Email Address: mmiller@hsc.wvu.edu; Affiliations: 1: Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, West Virginia; 2: Department of Community Medicine, West Virginia University, Morgantown, West Virginia; 3: National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia; Issue Info: Apr2002, Vol. 66 Issue 2, p233; Subject Term: Acetaminophen; Subject Term: Breast cancer; Subject Term: Mitogens; Subject Term: Gene expression; Subject Term: Cell proliferation; Author-Supplied Keyword: acetaminophen; Author-Supplied Keyword: c-myc gene; Author-Supplied Keyword: cell cycle; Author-Supplied Keyword: estrogen receptor; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: NF-κB; Number of Pages: 11p; Illustrations: 5 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-13838-004
AN - 2002-13838-004
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Derived Trail Making Test indices in a sample of marijuana abusers: Demographic effects.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2002/04//
VL - 112
IS - 4
SP - 429
EP - 438
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2002-13838-004. PMID: 12325396 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20020807. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Assessment; Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Marijuana. Minor Descriptor: Index (Testing). Classification: Neuropsychological Assessment (2225); Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 2002.
AB - Derived indices on the Trail Making Test (TMT), a test often used for screening for cognitive impairment, were examined in a sample of marijuana abusers in drug abuse treatment programs. A mixed-race sample of 259 Ss (aged 18 yrs and over) was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991 to 1993 in 96 programs in 11 cities in the US. Data were analyzed to determine the effects of demographic variables on derived indices created by adding, subtracting, multiplying, and dividing Parts A and B of the TMT in this large treatment sample of marijuana abusers. The variables of age, ethnicity, and education were statistically significant for the total (A+B), and interaction (A×B/100) derived indices of the TMT. The difference score (B-A) was significant only for ethnicity and the ratio score (B/A) was not significant for any demographic variable. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Derived Trail Making Test indices
KW - cognitive impairment
KW - marijuana abusers
KW - treatment program
KW - demographic effects
KW - 2002
KW - Cognitive Assessment
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Marijuana
KW - Index (Testing)
KW - 2002
DO - 10.1080/00207450290025563
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UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Meier, Kristen L.
T1 - Reporting results from studies evaluating diagnostic tests
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
Y1 - 2002/04/15/
VL - 24
IS - 8
M3 - Article
SP - 60
SN - 01964399
AB - Evaluating a new diagnostic test requires careful planning. It involves choosing the appropriate comparative procedure, patients, specimens, and individuals performing the tests. The type of study design used to evaluate a new test has a direct impact on how the study results can be reported. This article describes some statistically appropriate and inappropriate practices for reporting results from different studies evaluating qualitative diagnostic tests. Special attention is given to describing a practice called discrepant resolution and its associated problems. [Copyright &y& Elsevier]
AB - Copyright of Clinical Microbiology Newsletter is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diagnosis
KW - Medical research -- Evaluation
N1 - Accession Number: 7822816; Meier, Kristen L. 1; Affiliations: 1: Center for Devices and Radiological Health, Food and Drug Administration, USA; Issue Info: Apr2002, Vol. 24 Issue 8, p60; Subject Term: Diagnosis; Subject Term: Medical research -- Evaluation; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106972388
T1 - Effects of posture on dynamic back loading during a cable lifting task.
AU - Gallagher S
AU - Marras WS
AU - Davis KG
AU - Kovacs K
Y1 - 2002/04/15/
N1 - Accession Number: 106972388. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Spine -- Physiology
KW - Lifting
KW - Posture
KW - Comparative Studies
KW - Male
KW - Industry
KW - Kinematics
KW - Torso
KW - Electromyography
KW - Muscle Contraction
KW - Two-Way Analysis of Variance
KW - Adult
KW - Descriptive Statistics
KW - Mathematics
KW - Body Weights and Measures
KW - Models, Biological
KW - Biomechanics
KW - Biophysical Instruments
KW - Goniometry
KW - Shear
KW - Human
SP - 380
EP - 398
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 45
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA 15236-0070; sfg9@cdc.gov
U2 - PMID: 12028722.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gao, Pengfei
AU - Chen, Bean T.
AU - Baron, Paul A.
AU - Soderholm, Sidney C.
T1 - A Numerical Study of the Performance of an Aerosol Sampler with a Curved, Blunt, Multi-Orificed Inlet.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2002/05//
VL - 36
IS - 5
M3 - Article
SP - 540
EP - 553
SN - 02786826
AB - The purpose of this study was to numerically simulate the performance of an aerosol sampler with a curved, blunt, multi-orificed inlet in order to understand the sampling characteristics of the first prototype of the button personal inhalable aerosol sampler ("button sampler"). Because the button sampler inlet design is too complicated to apply a three-dimensional model, an axisymmetric two-dimensional model was created to be similar in geometry and to simulate the major features of the airflow through the sampler when facing the wind. Particle trajectories were calculated in a variety of wind velocities and were categorized into 5 groups based on their interactions with the curved surface of the sampling plane. Empirical sampling efficiencies of the button sampler for 3 particle sizes were used to adjust the calculated sampling efficiencies in an attempt to improve the accuracy of the two-dimensional axisymmetric model in accounting for interactions between particles and the surface of the inlet of the button sampler. Sampling efficiencies for other particle sizes were then predicted. The results showed that sampling efficiency decreased with increasing particle size up to approximately 40 μm and then remained virtually unchanged at about 35% up to 100 μm. Although the efficiencies were lower than the American Conference of Governmental Industrial Hygienists' (ACGIH) inhalability curve for larger particles, the pattern of the predicted sampling efficiency was quite similar to the ACGIH inhalability curve. Sampling efficiencies for liquid aerosol particles larger than 15 μm were predicted to be noticeably lower than those for solid particles. The results also showed that the multi-orificed curved surface played an important role in establishing a pressure drop with desired flow alignment inside the sampler, thus greatly reducing the wind effect and significantly improving the uniformity of particle deposition on the filter. The less uniform deposition found at high wind velocity can be improved by increasing the sampling flow rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Air flow
KW - Inlets
N1 - Accession Number: 6510882; Gao, Pengfei 1; Chen, Bean T. 1; Baron, Paul A. 2; Soderholm, Sidney C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2002, Vol. 36 Issue 5, p540; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Air flow; Thesaurus Term: Inlets; Number of Pages: 14p; Illustrations: 16 Diagrams, 8 Graphs; Document Type: Article
L3 - 10.1080/02786820252883784
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baron, Paul A.
AU - Bennett, James S.
T1 - Calculation of Leakage and Particle Loss in Filter Cassettes.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2002/05//
VL - 36
IS - 5
M3 - Article
SP - 632
EP - 641
SN - 02786826
AB - Experimental evidence of aerosol bypass leakage around the filter in plastic filter cassettes prompted an investigation using computational fluid dynamics to explain particle penetration through the leak. Axi-symmetric models of a cassette with several leak dimensions were constructed. The models predicted that submicrometer particles penetrated the leak, but that larger particles impacted on the filter surface. Experimental data from another study clearly indicated that larger solid particles were being lost from the surface of the filter during sampling. When particle bounce was invoked as an explanation for this loss of sampled solid particles, the theoretical loss from the filter in cassettes with large leaks exhibited characteristics similar to the experimental data. For small leaks, the mass loss behavior appeared to be more complex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Filters & filtration
KW - Fluid dynamics
N1 - Accession Number: 6510891; Baron, Paul A. 1; Bennett, James S. 1; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2002, Vol. 36 Issue 5, p632; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Filters & filtration; Subject Term: Fluid dynamics; Number of Pages: 10p; Illustrations: 9 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/02786820252883865
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Estill, Cheryl Fairfield
AU - Watkins, Daniel S.
AU - Hall, Ronald M.
AU - O'Brien, Dennis M.
AU - Shulman, Stanley A.
T1 - The Impact of Maintenance and Design for Ventilation Systems.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 344
EP - 351
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Ventilation systems need to be designed to include access for cleaning and preventive maintenance. Without such access, the exhaust volume will deteriorate. Because of access difficulties and the many demands on their time, plant managers are sometimes errant in performing proper preventive maintenance. Three surveys measuring workers' exposures to methylene chloride were conducted at the same furniture stripping facility. A new ventilation system was installed for the first survey, resulting in an exhaust volume of 2900 cfm and worker exposure to methylene chloride of 59 ppm (geometric mean). Immediately after the first survey, the gasoline-powered fan was replaced by a smaller capacity electrically powered fan. Deterioration in the ventilation system was seen after seven years. Problems included clogged slots, paint chips and sawdust deposits in plenums, and a loose and frayed fan belt. The second survey indicated a reduction in exhaust volume to 1060 cfm and increased worker exposure to 330 ppm. With the smaller capacity fan still in place, the system was otherwise upgraded to allow for easier access and maintenance was performed. The third survey showed that the ventilation system performance was better (exhaust volume improved to 2080 cfm)and the worker exposures were reduced to 73 ppm. This study shows the benefits of designing for preventive maintenance and the necessity of keeping the ventilation systems clean. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ventilation -- Design & construction
KW - Cleaning
KW - United States
KW - DIP TANK
KW - ENGINEERING
KW - FURNITURE STRIPPING
KW - METHYLENE CHLORIDE
KW - occupation
KW - SIC 7641
KW - Small business
KW - Ventilation
N1 - Accession Number: 6472396; Estill, Cheryl Fairfield 1; Watkins, Daniel S. 1; Hall, Ronald M. 1; O'Brien, Dennis M. 1; Shulman, Stanley A. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2002, Vol. 17 Issue 5, p344; Subject Term: Ventilation -- Design & construction; Subject Term: Cleaning; Subject: United States; Author-Supplied Keyword: DIP TANK; Author-Supplied Keyword: ENGINEERING; Author-Supplied Keyword: FURNITURE STRIPPING; Author-Supplied Keyword: METHYLENE CHLORIDE; Author-Supplied Keyword: occupation; Author-Supplied Keyword: SIC 7641; Author-Supplied Keyword: Small business; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 561720 Janitorial Services; Number of Pages: 8p; Illustrations: 4 Black and White Photographs, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10473220252864941
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Earnest, G. Scott
T1 - A Control Technology Evaluation of State-of-the-Art, Perchloroethylene Dry-Cleaning Machines.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 352
EP - 359
PB - Taylor & Francis Ltd
SN - 1047322X
AB - NIOSH researchers evaluated the ability of fifthgeneration dry-cleaning machines to control occupational exposure to perchloroethylene (PERC). Use of these machines is mandated in some countries; however, less than 1 percent of all U.S. shops have them. A study was conducted at a U.S. dry-cleaning shop where two fifth-generation machines were used. Both machines had a refrigerated condenser as a primary control and a carbon adsorber as a secondary control to recover PERC vapors during the dry cycle. These machines were designed to lower the PERC concentration in the cylinder at the end of the dry cycle to below 290 ppm. A single-beam infrared photometer continuously monitors the PERC concentration in the machine cylinder, and a door interlock prevents opening until the concentration is below 290 ppm. Personal breathing zone air samples were measured for the machine operator and presser. The operator had time-weighted average (TWA) PERC exposures that were less than 2 ppm. Highest exposures occurred during loading and unloading the machine and when performing routine machine maintenance. All presser samples were below the limit of detection. Real-time video exposure monitoring showed that the operator had peak exposures near 160 ppm during loading and unloading the machine (below the OSHA maximum of 300 ppm). This exposure (160 ppm) is an order of magnitude lower than exposures with more traditional machines that are widely used in the United States. The evaluated machines were very effective at reducing TWA PERC exposures as well as peak exposures that occur during machine loading and unloading. State-of-the-art dry-cleaning machines equipped with refrigerated condensers, carbon adsorbers, drum monitors, and door interlocks can provide substantially better protection than more traditional machines that are widely used in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tetrachloroethylene
KW - Industrial hygiene
KW - Dry cleaning machines
KW - United States
KW - Dry cleaning
KW - Engineering controls
KW - Exposure reduction
KW - PERCHLOROETHYLENE
KW - Technical feasibility
KW - Vapor recovery
N1 - Accession Number: 6472395; Earnest, G. Scott 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio; Issue Info: May2002, Vol. 17 Issue 5, p352; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Industrial hygiene; Subject Term: Dry cleaning machines; Subject: United States; Author-Supplied Keyword: Dry cleaning; Author-Supplied Keyword: Engineering controls; Author-Supplied Keyword: Exposure reduction; Author-Supplied Keyword: PERCHLOROETHYLENE; Author-Supplied Keyword: Technical feasibility; Author-Supplied Keyword: Vapor recovery; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 333310 Commercial and service industry machinery manufacturing; NAICS/Industry Codes: 417920 Service establishment machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333318 Other Commercial and Service Industry Machinery Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10473220252864950
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Klingner, Thomas D.
AU - Boeniger, Mark F.
T1 - A Critique of Assumptions About Selecting Chemical-Resistant Gloves: A Case for Workplace Evaluation of Glove Efficacy.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 360
EP - 367
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Wearing chemical-resistant gloves and clothing is the primary method used to prevent skin exposure to toxic chemicals in the workplace. The process for selecting gloves is usually based on manufacturers' laboratory-generated chemical permeation data. However, such data may not reflect conditions in the workplace where many variables are encountered (e.g., elevated temperature, flexing, pressure, and product variation between suppliers). Thus, the reliance on this selection process is questionable. Variables that may influence the performance of chemical-resistant gloves are identified and discussed. Passive dermal monitoring is recommended to evaluate glove performance under actual-use conditions and can bridge the gap between laboratory data and real-world performance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Gloves
KW - Design
KW - United States
KW - Chemical protection
KW - CHEMICAL-RESISTANT GLOVES
KW - GLOVE PERFORMANCE
KW - Occupational
KW - Skin protection
N1 - Accession Number: 6472406; Klingner, Thomas D. 1; Boeniger, Mark F. 2; Affiliations: 1: Colormetric Laboratories, Inc., Des Plaines, Illinois; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2002, Vol. 17 Issue 5, p360; Thesaurus Term: Hazardous substances; Subject Term: Gloves; Subject Term: Design; Subject: United States; Author-Supplied Keyword: Chemical protection; Author-Supplied Keyword: CHEMICAL-RESISTANT GLOVES; Author-Supplied Keyword: GLOVE PERFORMANCE; Author-Supplied Keyword: Occupational; Author-Supplied Keyword: Skin protection; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1080/10473220252864969
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boeniger, Mark F.
AU - Klingner, Thomas D.
T1 - In-Use Testing and Interpretation of Chemical-Resistant Glove Performance.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 368
EP - 378
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Issuing gloves to workers is the most common approach to protecting against skin contact with hazardous chemicals. Typically, glove materials are selected and duration of wear is estimated based on comparisons of laboratory test data. Those who select the glove materials often fail to verify their selections by testing the glove during actual use. This failure poses a common but potentially serious hazard to workers. Although methods are available for assessing permeation rates during actual use, such testing is unlikely without acceptable exposure guidance criteria for decision making. This document reviews methods for testing glove performance during actual use and suggests an approach for estimating acceptable exposure guidance criteria for evaluation of chemicals that are systemically absorbed. It is the authors' opinion that as of now an approach to estimating exposure criteria for chemical irritants and sensitizers may not be feasible. With available data resources, acceptable glove exposure criteria could be generated for use in assessing the risk of using specific gloves for handling many compounds in occupational settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Gloves
KW - Skin
KW - Design
KW - CHEMICAL-RESISTANT
KW - DOCUMENTATION
KW - DURATION OF USE
KW - Evaluation
KW - GLOVE PERFORMANCE
KW - Occupational
KW - PERMEATION RESISTANCE
N1 - Accession Number: 6472405; Boeniger, Mark F. 1; Klingner, Thomas D. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: CLI Inc., Des Plaines, Illinois; Issue Info: May2002, Vol. 17 Issue 5, p368; Thesaurus Term: Hazardous substances; Subject Term: Gloves; Subject Term: Skin; Subject Term: Design; Author-Supplied Keyword: CHEMICAL-RESISTANT; Author-Supplied Keyword: DOCUMENTATION; Author-Supplied Keyword: DURATION OF USE; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: GLOVE PERFORMANCE; Author-Supplied Keyword: Occupational; Author-Supplied Keyword: PERMEATION RESISTANCE; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/10473220252864978
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huber, Wolfgang W.
AU - Prustomersky, Sonja
AU - Delbanco, Evert
AU - Uhl, Maria
AU - Scharf, Gerlinde
AU - Turesky, Robert J.
AU - Thier, Ricarda
AU - Schulte-Hermann, Rolf
T1 - Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2002/05//
VL - 76
IS - 4
M3 - Article
SP - 209
EP - 217
PB - Springer Science & Business Media B.V.
SN - 03405761
AB - The coffee components kahweol and cafestol (K/C) have been reported to protect the colon and other organs of the rat against the formation of DNA adducts by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and aflatoxin B1. PhIP is a cooked-food mutagen to which significant human exposure and a role in colon cancer etiology are attributed, and, interestingly, such cancers appear to develop at a lower rate in consumers of coffees with high amounts of K/C. Earlier studies in rodent liver have shown that a key role in the chemopreventive effect of K/C is likely to be due to the potential of these compounds to induce the detoxification of xenobiotics by glutathione transferase (GST) and to enhance the synthesis of the corresponding co-factor glutathione. However, mutagens like PhIP may also be detoxified by UDP-glucuronosyl transferase (UDPGT) for which data are lacking regarding a potential effect of K/C. Therefore, in the present study, we investigated the effect of K/C on UDPGT and, concomitantly, we studied overall GST and the pattern of individual GST classes, particularly GST-θ, which was not included in earlier experiments. In addition, we analyzed the organ-dependence of these potentially chemopreventive effects. K/C was fed to male F344 rats at 0.122% in the chow for 10 days. Enzyme activities in liver, kidney, lung, colon, salivary gland, pancreas, testis, heart and spleen were quantified using five characteristic substrates and the hepatic protein pattern of GST classes α, µ, and π was studied with affinity chromatography/HPLC. Our study showed that K/C is not only capable of increasing overall GST and GST classes α, µ, and π but also of enhancing UDGPT and GST-θ. All investigated K/C effects were strongest in liver and kidney, and some response was seen in lung and colon but none in the other organs. In summary, our results show that K/C treatment leads to a wide spectrum of increases in phase II detoxification enzymes. Notably, these effects occurred preferentially in the well perfused organs liver and kidney, which may thus not only contribute to local protection but also to anti-carcinogenesis in distant, less stimulated organs such as the colon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enzymology
KW - Glucuronosyltransferase
KW - Glycosyltransferases
KW - Glutathione transferase
KW - Preventive medicine
KW - Biochemistry
KW - Chemoprevention
KW - Coffee
KW - Glutathione-S-transferase
KW - Organ specificity
KW - Rat
KW - UDP-glucuronosyl transferase
N1 - Accession Number: 15731910; Huber, Wolfgang W. 1; Email Address: wolfgang.huber@univie.ac.at; Prustomersky, Sonja 1; Delbanco, Evert 2,3; Uhl, Maria 1; Scharf, Gerlinde 1; Turesky, Robert J. 4,5; Thier, Ricarda 2,6; Schulte-Hermann, Rolf 1; Affiliations: 1: Institut für Krebsforschung, University of Vienna, Borschkegasse, 8A, 1090 Vienna, Austria; 2: Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystraße 67, 44139 Dortmund, Germany; 3: Henkel KgaA, VTB-Biologie/Produktsicherheit, Abteilung Toxikologie, 40191 Düsseldorf, Germany; 4: Nestlé Research Centre, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland; 5: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; 6: Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Queensland, 4072, Australia; Issue Info: May2002, Vol. 76 Issue 4, p209; Thesaurus Term: Enzymology; Subject Term: Glucuronosyltransferase; Subject Term: Glycosyltransferases; Subject Term: Glutathione transferase; Subject Term: Preventive medicine; Subject Term: Biochemistry; Author-Supplied Keyword: Chemoprevention; Author-Supplied Keyword: Coffee; Author-Supplied Keyword: Glutathione-S-transferase; Author-Supplied Keyword: Organ specificity; Author-Supplied Keyword: Rat; Author-Supplied Keyword: UDP-glucuronosyl transferase; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s00204-002-0322-1
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ahmad, Syed R.
AU - Kortepeter, Cindy
AU - Brinker, Allen
AU - Min Chen
AU - Beitz, Julie
T1 - Renal Failure Associated with the Use of Celecoxib and Rofecoxib.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/05//
VL - 25
IS - 7
M3 - Article
SP - 537
EP - 544
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Objective: Celecoxib and rofecoxib are two relatively new nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively inhibit the cyclo-oxygenase-2 (COX-2) isoenzyme at therapeutic concentrations. The nephrotoxic potential of selective COX-2 inhibitors has not been clearly established. This study was conducted in order to understand the association between acute renal failure and the two COX-2 inhibitors celecoxib and rofecoxib. Methods: A search was performed in the US Food and Drug Administration's (FDA) Adverse Event Reporting System (AERS) to identify cases of renal failure submitted to the FDA. A MEDLINE search of the English language literature was also performed to identify published cases of renal failure associated with celecoxib and rofecoxib. Results: One hundred twenty-two and 142 domestic US cases of celecoxib and rofecoxib-associated renal failure, respectively, were identified in the AERS database. The literature search identified 19 cases of acute renal impairment in association with celecoxib and rofecoxib. In addition, drug regulatory authorities in the UK, Canada, and Australia have received about 50 reports of renal failure with celecoxib and rofecoxib. Descriptive statistics of the AERS cases have been summarised in this report. Conclusions: Data from AERS and published case reports suggest that use of both these drugs is associated with renal effects similar to that of conventional nonselective NSAIDs. Physicians should be aware that serious or life-threatening renal failure has been reported in patients with normal or impaired renal function after short-term therapy with celecoxib and rofecoxib. Patients at greatest risk for renal injury are those with pre-existing renal impairment, heart failure, liver dysfunction, those taking diuretics and/or ACE inhibitors, and the elderly. Kidney function should be monitored closely for any signs of potential renal injuries soon after initiating treatment with these agents, especially in high-risk populations. In addition, healthcare practitioners should adequately warn patients of the signs and symptoms of serious renal toxicity, and of the need for them to see their physician promptly if they occur. Celecoxib and rofecoxib are not recommended for use in patients with advanced renal disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nonsteroidal anti-inflammatory agents
KW - Celecoxib
KW - Cyclooxygenase 2 -- Inhibitors
KW - Kidney diseases
KW - Drugs -- Side effects
N1 - Accession Number: 16597547; Ahmad, Syed R. 1; Kortepeter, Cindy 1; Brinker, Allen 1; Min Chen 1; Beitz, Julie 1; Affiliations: 1: Division of Drug Risk Evaluation, Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Issue Info: May2002, Vol. 25 Issue 7, p537; Subject Term: Nonsteroidal anti-inflammatory agents; Subject Term: Celecoxib; Subject Term: Cyclooxygenase 2 -- Inhibitors; Subject Term: Kidney diseases; Subject Term: Drugs -- Side effects; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Toraason, Mark
AU - Hayden, Charles
AU - Marlow, Dave
AU - Rinehart, Richard
AU - Mathias, Patty
AU - Werren, Dwight
AU - deBord, Gayle D.
AU - Reid, Thomas M.
T1 - DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2002/05//
VL - 75
IS - 4
M3 - Erratum
SP - 279
EP - 279
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Presents a correction to the article " DNA strand breaks, oxidative damage, and 1-OH pyrene in roofers with coal-tar pitch dust and/or asphalt fume exposure," previously published in the periodical.
KW - Periodicals
KW - Human exposure
KW - PGME
KW - Toxicokinetics
KW - Urine
N1 - Accession Number: 16129538; Toraason, Mark 1; Hayden, Charles 1; Marlow, Dave 1; Rinehart, Richard 2; Mathias, Patty 1; Werren, Dwight 1; deBord, Gayle D. 1; Reid, Thomas M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; 2: Harvard School of Public Health, Boston, Massachusetts, USA.; Issue Info: May2002, Vol. 75 Issue 4, p279; Subject Term: Periodicals; Author-Supplied Keyword: Human exposure; Author-Supplied Keyword: PGME; Author-Supplied Keyword: Toxicokinetics; Author-Supplied Keyword: Urine; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 451212 News Dealers and Newsstands; Number of Pages: 1p; Document Type: Erratum
L3 - 10.1007/s00420-002-0321-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Crawford, Lester
AU - Crawford, Lester M Jr
T1 - From the Food and Drug Administration.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2002/05//5/1/2002
VL - 287
IS - 17
M3 - journal article
SP - 2203
EP - 2203
SN - 00987484
AB - Reports several news briefs related to the United States Food and Drug Administration (FDA). Conduction of a workshop by the FDA and the Plasma Protein Therapeutics Association entitled 'Comparability Studies for Human Plasma-Derived Therapeutics'; Approval of SIR-Spheres by the FDA for the treatment of unresectable metastatic liver tumors; Creation of a new television series for physicians and other health care professionals, called 'FDA Patient Safety News'; Others.
KW - UNITED States. Food & Drug Administration
KW - PLASMA Protein Therapeutics Association (Organization)
KW - LIVER tumors -- Treatment
KW - TELEVISION programs
N1 - Accession Number: 6589433; Crawford, Lester; Crawford, Lester M Jr 1; Source Information: 5/1/2002, Vol. 287 Issue 17, p2203; Subject: UNITED States. Food & Drug Administration; Subject: PLASMA Protein Therapeutics Association (Organization); Subject: LIVER tumors -- Treatment; Subject: TELEVISION programs; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 6589433
T1 - From the Food and Drug Administration.
AU - Crawford, Lester
AU - Crawford, Lester M Jr
Y1 - 2002/05//5/1/2002
N1 - Accession Number: 6589433. Language: English. Entry Date: 20021213. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Frenchay Dysarthria Assessment (FDA). NLM UID: 7501160.
KW - Biological Products -- Therapeutic Use
KW - Blood Proteins -- Therapeutic Use
KW - Radioisotopes -- Administration and Dosage
KW - Latex
KW - Databases
KW - Radiopharmaceuticals -- Administration and Dosage
KW - Clinical Trials
KW - Liver Neoplasms -- Radiotherapy
KW - Equipment and Supplies -- Adverse Effects
KW - United States
KW - United States Food and Drug Administration
KW - Equipment Safety
KW - Prostheses and Implants
KW - Clinical Assessment Tools
SP - 2203
EP - 2203
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 287
IS - 17
CY - Chicago, Illinois
PB - American Medical Association
AB - Reports several news briefs related to the United States Food and Drug Administration (FDA). Conduction of a workshop by the FDA and the Plasma Protein Therapeutics Association entitled 'Comparability Studies for Human Plasma-Derived Therapeutics'; Approval of SIR-Spheres by the FDA for the treatment of unresectable metastatic liver tumors; Creation of a new television series for physicians and other health care professionals, called 'FDA Patient Safety News'; Others.
SN - 0098-7484
AD - US Food and Drug Administration, USA
U2 - PMID: 11980508.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
ID - 106987295
T1 - Safety of newly approved drugs: implications for prescribing.
AU - Temple RJ
AU - Himmel MH
AU - Temple, Robert J
AU - Himmel, Martin H
Y1 - 2002/05//5/1/2002
N1 - Accession Number: 106987295. Language: English. Entry Date: 20021213. Revision Date: 20161112. Publication Type: commentary; commentary; editorial. Original Study: Lasser KE, Allen PD, Woolhandler SJ, Himmelstein DU, Wolfe SM, Bohr DH, et al. Timing of new black box warnings and withdrawals for prescription medications. (JAMA) 5/1/2002; 287 (17): 2215-2296. Commentary: Skylstad KA. Pharmacy journal club. [Commentary on] Safety of newly approved drugs: implications for prescribing [Letter]. (ADV PHARM) 2002 Fall; 1 (1): 69-70. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Adverse Drug Event
KW - Drug Labeling
KW - Drugs, Prescription -- Adverse Effects
KW - United States Food and Drug Administration
KW - Drug Approval
KW - United States
KW - Adverse Drug Event -- Prevention and Control
SP - 2273
EP - 2275
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 287
IS - 17
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Center for Drug Evaluation and Research Policy, Food and Drug Administration, 5600 Fishers Ln, HFD-101, Rockville, MD 20857; temple@cder.fda.gov
U2 - PMID: 11980528.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822619
T1 - Development of innovative teaching materials: clinical pharmacology problem-solving (CPPS) units: comparison with patient-oriented problem-solving units and problem-based learning--a 10-year review.
AU - Lathers CM
AU - Smith CM
Y1 - 2002/05//
N1 - Accession Number: 105822619. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Pharmacy and Pharmacology -- Education
KW - Problem-Based Learning
KW - Teaching
KW - Anticonvulsants
KW - Education, Medical
KW - Education, Pharmacy
KW - Eye Diseases
KW - Geriatrics -- Education
KW - Glaucoma
KW - Netherlands
KW - Osteopathy -- Education
KW - Patients
KW - Program Evaluation
KW - United States
SP - 477
EP - 491
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The First Teaching Clinic in Clinical Pharmacology, sponsored by the American College of Clinical Pharmacology in September 1992, was designed for the preparation and development of new clinical pharmacology problem-solving (CPPS) units. CPPS units are case histories that illustrate pertinent principles in clinical pharmacology. Each unit consists of the following sections: introduction, learning objectives, pretest, four clinical pharmacology scenarios, posttest, answers to pre- and posttest questions, and selected references. The clinical pharmacology content of the CPPS units place greater emphasis on clinical information, drug selection, and risk/benefit analyses, and thus they complement the basic pharmacology presented in the patient-oriented problem-solving (POPS) units. In general, the CPPS units are intended for use by students more advanced in clinical pharmacology than first- and second-year medical students. The CPPS unit 'Clinical Pharmacology of Antiepileptic Drug Use: Clinical Pearls about the Perils of Patty' was developed for use by third- and fourth-year medical students doing rotations in neurology or clinical pharmacology; advanced pharmacy students; residents in neurology, pediatrics, internal medicine, and family practice; fellows in clinical pharmacology, and those taking the board examination in clinical pharmacology. The CPPS unit titled 'Geriatric Clinical Psychopharmacology' was written for third- and fourth-year medical students; residents in psychiatry, family practice, and internal medicine;fellows in clinical pharmacology; and those studying for boards in clinical pharmacology. The CPPS unit 'Anisocoria and Glaucoma' was written for more advanced students of clinical pharmacology. The CPPS unit titled 'Antiepileptic Drugs' was intended for second-year medical students. The second teaching clinic was held in November 1993 and focused on the development and editing of the CPPS units and their evaluations by faculty and students from academic centers. Evaluations by faculty and students have been overwhelmingly positive. Requests to use the CPPS units in various clinical pharmacology teaching programs were received from numerous schools within the United States and from abroad. The third teaching clinic in September 1995 included a follow-up focused on the uses of drug information databases in case problem exercises. These examples are presented to demonstrate the variety of educational activities the American College of Clinical Pharmacology is sponsoring to fulfill its strategic initiative dedicated to offer innovative teaching programs and to develop new teaching materials in clinical pharmacology. Collectively, all of the teaching clinics, symposia, and workshop efforts, sponsored by the various academic professional societies alone or together over the past decade, are necessary if new and innovative teaching materials in the field of basic science and in the fields of pharmacology and clinical pharmacology are to be continuously developed to keep pace with the new, rapidly changing developments in medicine to provide the best treatment for patients in the 21st century.
SN - 0091-2700
AD - U.S. Food and Drug Administration, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Rockville, Maryland 20855, USA.
U2 - PMID: 12017342.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106984502
T1 - Association of language spoken at home with health and school issues among Asian American adolescents.
AU - Yu SM
AU - Huang ZJ
AU - Schwalberg RH
AU - Overpeck MD
AU - Kogan MD
Y1 - 2002/05//
N1 - Accession Number: 106984502. Language: English. Entry Date: 20021206. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0376370.
KW - Asians -- In Adolescence
KW - Immigrants -- In Adolescence
KW - Multilingualism
KW - Risk Taking Behavior -- In Adolescence
KW - Health Behavior -- In Adolescence
KW - School Health -- In Adolescence
KW - Secondary Analysis
KW - Cross Sectional Studies
KW - Surveys
KW - Record Review
KW - Questionnaires
KW - Home Environment
KW - Student Satisfaction
KW - Interpersonal Relations
KW - Parent-Child Relations
KW - Family Characteristics
KW - Educational Status
KW - Multiple Logistic Regression
KW - Bivariate Statistics
KW - Multivariate Statistics
KW - Descriptive Statistics
KW - Chi Square Test
KW - P-Value
KW - Odds Ratio
KW - Confidence Intervals
KW - Data Analysis Software
KW - Age Factors
KW - Sex Factors
KW - Male
KW - Female
KW - Child
KW - Adolescence
KW - United States
KW - Human
SP - 192
EP - 198
JO - Journal of School Health
JF - Journal of School Health
JA - J SCH HEALTH
VL - 72
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The study examined the association of language spoken at home with the school and health risks and behaviors of Asian American adolescents. Using the United States component of the 1997-1998 World Health Organization Study of Health Behavior in School Children, bivariate and multiple logistic regression analyses were conducted of records for Asian children to explore the relationship between language spoken at home and outcome variables regarding health behaviors, psychosocial and school risk factors, and parental factors. Compared to those who usually speak English at home, adolescents who usually speak another language, or who speak two languages equally, face a greater risk for health risk factors, psychosocial and school risk factors, and parental risk factors. Not speaking English at home was associated with higher health risks, including not wearing seat belts and bicycle helmets; higher psychosocial and school risk factors, including feeling that they do not belong at school, difficulty making new friends, and lacking confidence; and higher parental risks, including reporting that parents were not ready to help them or willing to talk to teachers. Adolescents less acculturated to the United States experience a variety of physical and psychosocial risks. School-based interventions such as early identification and outreach, needs assessment, and counseling and support services should be provided to immigrant students and their families.
SN - 0022-4391
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18-41, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 12109174.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Hyung Sik
AU - Shin, Jae-Ho
AU - Moon, Hyun Ju
AU - Kang, Il Hyun
AU - Kim, Tae Sung
AU - Kim, In Young
AU - Seok, Ji-Hyun
AU - Pyo, Myoung-Yun
AU - Han, Soon Young
T1 - Comparative estrogenic effects of p-nonylphenol by 3-day uterotrophic assay and female pubertal onset assay
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2002/05//
VL - 16
IS - 3
M3 - Article
SP - 259
SN - 08906238
AB - Nonylphenol (NP) is widely used as a component of detergents, paints, pesticides, and many other formulated products. Several studies have demonstrated that NP is estrogenic in fish, avian, and mammalian cells. NP also competitively inhibits the binding of 17β-estradiol (E2) to the estrogen receptor (ER). However, there are relatively few in vivo data related to this issue in mammals. The aim of this study was to investigate the estrogenic activity of NP in animal models. We performed a 3-day uterotrophic assay using immature female rats for comparison with other endpoints of Tier I screening including vaginal opening (VO) in prepubertal intact female rats. For the uterotrophic assay, diethylstilbestrol (DES) (0.2 and 1.0 μg/kg) and p-NP (10, 25, 50, 100, and 200 mg/kg) were administered subcutaneously to immature Sprague–Dawley female rats for 3 consecutive days (postnatal days (PND) 20, 21, and 22). For the female pubertal onset assay, DES (0.2, 1.0, and 5.0 μg/kg) and p-NP (10, 50, and 100 mg/kg) were administered daily by oral gavage from 21 days of age for 20 days. In the uterotrophic assay, statistically significant increases in uterine wet weight were observed at doses of 100 and 200 mg/kg p-NP. DES (0.2 and 1.0 μg/kg) also significantly increased uterine weight compared to the vehicle control. In the female pubertal onset assay, the age of VO was advanced following oral exposure to DES (1.0 and 5.0 μg/kg) and p-NP (50 and 100 mg/kg). Estrous cyclicity was monitored in prepubertal rats from the day of VO to the day of necropsy. Irregular estrous cycles were observed in the groups treated with DES (5.0 μg/kg) and p-NP (50 and 100 mg/kg). High-dose DES (5.0 μg/kg) produced a persistent estrus state, whereas p-NP (50 and 100 mg/kg) increased the number of days in diestrus. Serum thyroxine (T4) concentrations were decreased in a dose-dependent manner by DES and p-NP treatment. A significant decrease in serum T4 level was observed at high-dose DES (5.0 μg/kg) and p-NP (100 mg/kg). Serum TSH level was significantly increased by DES (5.0 μg/kg) treatment. Statistically significant decreases in ovarian weight were observed in female rats treated with DES (5.0 μg/kg) and p-NP (100 mg/kg). Our data demonstrate that p-NP can accelerate the onset of puberty and alter estrous cyclicity in prepubertal female rats at oral doses lower than the subcutaneous doses typically used in the uterotrophic assay. We therefore suggest that the female pubertal onset assay may be used as a sensitive testing method to detect environmental agents with weak estrogenic activity, but requires further research. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nonylphenol
KW - Estrogen receptors
KW - Diethylstilbestrol
KW - Estrous cyclicity
KW - Female pubertal onset assay
KW - p-Nonylphenol
KW - Uterotrophic assay
KW - Vaginal opening
N1 - Accession Number: 7846180; Kim, Hyung Sik 1; Shin, Jae-Ho 1; Moon, Hyun Ju 1; Kang, Il Hyun 1; Kim, Tae Sung 1; Kim, In Young 1; Seok, Ji-Hyun 1; Pyo, Myoung-Yun 2; Han, Soon Young 1; Email Address: soonyoungh@kfda.go.kr; Affiliations: 1: Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, South Korea; 2: College of Pharmacy, Sookmyung Women’s University, Chungpa-dong-2ka, Yongsan-ku, Seoul, South Korea; Issue Info: May2002, Vol. 16 Issue 3, p259; Subject Term: Nonylphenol; Subject Term: Estrogen receptors; Author-Supplied Keyword: Diethylstilbestrol; Author-Supplied Keyword: Estrous cyclicity; Author-Supplied Keyword: Female pubertal onset assay; Author-Supplied Keyword: p-Nonylphenol; Author-Supplied Keyword: Uterotrophic assay; Author-Supplied Keyword: Vaginal opening; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hyung Sik Kim
AU - Jae-Ho Shin
AU - Hyun Ju Moon
AU - Tae Sung Kim
AU - Il Hyun Kang
AU - Ji-Hyun Seok
AU - In Young Kim
AU - Kui Lea Park
AU - Soon Young Han
T1 - Evaluation of the 20-Day Pubertal Female Assay in Sprague-Dawley Rats Treated with DES, Tamoxifen, Testosterone, and Flutamide.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/05//
VL - 67
IS - 1
M3 - Article
SP - 52
EP - 62
PB - Oxford University Press / USA
SN - 10966080
AB - The Endocrine Disrupter Screening and Testing Advisory Committee (EDSTAC) has recommended the rodent pubertal female assay as a Tier I test to detect potential endocrine disrupters (EDs). This assay is designed to screen estrogenic activity in immature rats exposed to chemicals during sexual maturation. The aim of this study was to evaluate whether this assay can detect the EDs with effects brought about through various mechanisms. Immature Sprague-Dawley female rats (21 days of age) were dosed daily for 20 days by oral gavage (DES, tamoxifen, and flutamide) or sc injection (testosterone). The mean age at vaginal opening (VO) was 32.3 ± 0.5 days in control rats. Although VO was unaffected by DES at doses of 0.2 and 1.0 μg/kg, a high dose of DES (5.0 μg/kg) significantly advanced the age at VO to 24 days. Both tamoxifen (50 and 200 μg/kg) and flutamide (25 mg/kg) also significantly accelerated VO to 27.8 ± 0.5, 25.1 ± 0.1, and 26.1 ± 0.1, respectively. However, testosterone dose-dependently delayed VO (exposure to 1.0 mg/kg extended VO to 37.3 ± 0.8 days, and VO did not occur in 2 of 10 animals by the time of necropsy at 41 days of age). Estrous cyclicity was monitored in rats from VO to necropsy. Irregular cycles were observed in the groups treated with DES (5.0 μg/kg), tamoxifen (200 μg/kg), testosterone (1.0 mg/kg), and flutamide (25 mg/kg). High dose of DES showed a persistent estrus state throughout the entire observation period. In addition, the number of days in diestrus was increased by tamoxifen (200 μg/kg) and flutamide (25 mg/kg) treatments. Significant decreases in ovarian weight were observed in 5.0 μg/kg DES (64% of control), 25 mg/kg flutamide (76% of control), and 200 μg/kg tamoxifen (47% of control). Testosterone also significantly decreased the ovarian weights in all treatment groups. Uterine weights were also decreased significantly at high doses of tamoxifen (200 μg/kg, 39% of control) or testosterone (1.0 mg/kg, 47% of control). In hormone analysis, tamoxifen significantly increased serum E2 levels at 50 μg/kg. The mean serum levels of TSH were significantly increased in tamoxifen (10 and 50 μg/kg), testosterone (0.2 mg/kg), and flutamide (1.0 and 25 mg/kg) treatment groups compared with the control. However, serum T4 levels were significantly reduced by testosterone. Furthermore, serum T3 levels were significantly increased in DES, tamoxifen (10 and 50 μg/kg), testosterone (1.0 mg/kg), and flutamide (1.0 and 5 mg/kg). Our data demonstrate that the rodent pubertal female assay is useful for identifying potential EDs having not only estrogenic/antiestrogenic but also androgenic/antiandrogenic activities. However, further validation study is necessary to identify chemicals that operate through other action mechanisms, including steroid biosynthesis inhibitors and thyroid inhibitors. Moreover, additional data on other compounds with weak endocrine disrupting activity will be required to further characterize the sensitivity of the female pubertal assay. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endocrine disruptors
KW - Estrogen
KW - Tamoxifen
KW - Puberty
KW - Flutamide
KW - Ovaries
KW - Testosterone
KW - Rats as laboratory animals
KW - DES
KW - endocrine disrupters
KW - estrous cyclicity
KW - female pubertal assay
KW - flutamide
KW - hormone analysis
KW - tamoxifen
KW - testosterone
KW - vaginal opening
N1 - Accession Number: 44406302; Hyung Sik Kim 1; Jae-Ho Shin 1; Hyun Ju Moon 1; Tae Sung Kim 1; Il Hyun Kang 1; Ji-Hyun Seok 1; In Young Kim 1; Kui Lea Park 1; Soon Young Han 1; Email Address: soonyoungh@kfda.go.kr; Affiliations: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong Eunpyung-gu, Seoul 122-704, Korea; Issue Info: May2002, Vol. 67 Issue 1, p52; Thesaurus Term: Endocrine disruptors; Subject Term: Estrogen; Subject Term: Tamoxifen; Subject Term: Puberty; Subject Term: Flutamide; Subject Term: Ovaries; Subject Term: Testosterone; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: DES; Author-Supplied Keyword: endocrine disrupters; Author-Supplied Keyword: estrous cyclicity; Author-Supplied Keyword: female pubertal assay; Author-Supplied Keyword: flutamide; Author-Supplied Keyword: hormone analysis; Author-Supplied Keyword: tamoxifen; Author-Supplied Keyword: testosterone; Author-Supplied Keyword: vaginal opening; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chu, Chia-Chium
AU - Wu, Yuh-Shen
AU - Fu, Peter Pi-Cheng
T1 - Emission characters of particulate concentrations and dry deposition studies for incense burning at a Taiwanese temple.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2002/05//
VL - 18
IS - 4
M3 - Article
SP - 183
EP - 190
PB - Sage Publications, Ltd.
SN - 07482337
AB - Suspended particulate concentrations were measured at the Tzu Yun Yen temple in the Taichung region of Taiwan. The temple performs traditional incense burning. A universal sampler and a micro-orifice uniform deposited impactor (MOUDI) sampler with a dry deposition plate were used to measure the particulate concentrations. The results show that the average PM[sub 2.5]/PM[sub 10] ratio was 74% during the incense burning period at this temple. In addition, the average suspended particulate (PM[sub 10]) element concentration of anthropogenic element Zn (495 ng/m[sup 3]) was higher than the other anthropogenic elements (Pb, Mn, Ni, and Cd). Furthermore, the average mass size distribution was bimodal with major peaks occurring at 0.32-0.56 μm and 5.6-10 μm during the incense burning period. The dry deposition velocities of Cd used fine particulates (PM[sub 2.5]) and suspended particulate (PM[sub 10]) mode were 1.86 and 0.99 cm/s in this study, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Zinc
KW - Lead
KW - Nickel
KW - Cadmium
KW - Incense
KW - Temples
KW - DRY DEPOSITION VELOCITIES
KW - INCENSE
KW - METAL ELEMENT
KW - PARTICULATE MATTER
KW - SIZE DISTRIBUTION
KW - TEMPLE
N1 - Accession Number: 10832578; Fang, Guor-Cheng 1; Chu, Chia-Chium 2; Wu, Yuh-Shen 1; Fu, Peter Pi-Cheng 3; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan; 2: The chief of Intensive Care Unit, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; Issue Info: 2002, Vol. 18 Issue 4, p183; Thesaurus Term: Zinc; Thesaurus Term: Lead; Thesaurus Term: Nickel; Thesaurus Term: Cadmium; Subject Term: Incense; Subject Term: Temples; Author-Supplied Keyword: DRY DEPOSITION VELOCITIES; Author-Supplied Keyword: INCENSE; Author-Supplied Keyword: METAL ELEMENT; Author-Supplied Keyword: PARTICULATE MATTER; Author-Supplied Keyword: SIZE DISTRIBUTION; Author-Supplied Keyword: TEMPLE; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 813110 Religious Organizations; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 8p; Document Type: Article
L3 - 10.1191/0748233702th140oa
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brennan, Michael J.
AU - Delogu, Giovanni
T1 - The PE multigene family: a ‘molecular mantra’ for mycobacteria
JO - Trends in Microbiology
JF - Trends in Microbiology
Y1 - 2002/05//
VL - 10
IS - 5
M3 - Article
SP - 246
SN - 0966842X
AB - The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Trends in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacteria
KW - Antigens
KW - Bacterial genetics
KW - Mycobacterium tuberculosis
N1 - Accession Number: 7792493; Brennan, Michael J. 1; Email Address: Brennan@cber.fda.gov; Delogu, Giovanni 2; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29 Room 502, 29 Lincoln Drive, Bethesda, MD 20892, USA.; 2: Dept of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy.; Issue Info: May2002, Vol. 10 Issue 5, p246; Thesaurus Term: Mycobacteria; Thesaurus Term: Antigens; Thesaurus Term: Bacterial genetics; Subject Term: Mycobacterium tuberculosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-01398-001
AN - 2002-01398-001
AU - Ward, Kenneth D.
AU - Vander Weg, Mark W.
AU - Kovach, Kristen Wood
AU - Klesges, Robert C.
AU - DeBon, Margaret W.
AU - Haddock, C. Keith
AU - Talcott, G. Wayne
AU - Lando, Harry A.
T1 - Ethnic and gender differences in smoking and smoking cessation in a population of young adult Air Force recruits.
JF - American Journal of Health Promotion
JO - American Journal of Health Promotion
JA - Am J Health Promot
Y1 - 2002/05//May-Jun, 2002
VL - 16
IS - 5
SP - 259
EP - 266
CY - US
PB - American Journal of Health Promotion
SN - 0890-1171
SN - 2168-6602
AD - Ward, Kenneth D., U Memphis Ctr for Community Health, 5050 Poplar Avenue, Suite 1800, Memphis, TN, US, 38157
N1 - Accession Number: 2002-01398-001. PMID: 12053437 Partial author list: First Author & Affiliation: Ward, Kenneth D.; U Ctr for Community Health, Memphis, TN, US. Other Publishers: Sage Publications. Release Date: 20020619. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Sex Differences; Nicotine; Racial and Ethnic Differences; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Military Personnel. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. Page Count: 8. Issue Publication Date: May-Jun, 2002.
AB - Examined gender and ethnic differences in smoking and smoking cessation in a population of young adult military recruits. A self-administered survey of demographics, tobacco use, and other health risk behaviors was administered at the start of basic military training. All recruits who entered the U. S. Air Force between September 1995 and September 1996 participated in this study (aged 17-35). Recruits completed a written 53-item behavioral risk questionnaire. Measures examined in the present study included smoking status; demographics; smoking history; and nicotine dependence. These findings document important gender and ethnic differences in cigarette smoking among military recruits. Whites and Native Anucans were more likely to smoke, less likely to quit, and more nicotine-dependent than other ethnic groups. Across gender/ethnicity groups, smoking rates were especially high among while women, with nearly one-third smoking daily until entry into basic training. Gender differences were not observed in cessation rates, but Hispanics were more likely than other ethnic groups to have quit smoking. The results highlight the need to develop efftctive cessation interventions for this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking
KW - ethnicity
KW - gender differences
KW - nicotine dependence
KW - military
KW - cessation
KW - 2002
KW - Human Sex Differences
KW - Nicotine
KW - Racial and Ethnic Differences
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Military Personnel
KW - 2002
DO - 10.4278/0890-1171-16.5.259
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-13234-011
AN - 2002-13234-011
AU - Hennessy, Kevin D.
AU - Green-Hennessy, Sharon
AU - Hijjazi, Kamal
T1 - State variations in complaint rates to protection and advocacy systems.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2002/05//
VL - 53
IS - 5
SP - 535
EP - 535
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2002-13234-011. PMID: 11986499 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Hennessy, Kevin D.; US Dept of Health & Human Services, Washington, DC, US. Release Date: 20020605. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Abuse Reporting; Civil Rights; Mental Disorders; Residential Care Institutions; Statistics. Minor Descriptor: Health Care Services. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Location: US. Methodology: Empirical Study. Page Count: 1. Issue Publication Date: May, 2002.
AB - Using US Census Bureau data to generate population-based estimates, the authors investigated the variability of abuse, neglect, and civil rights violation complaints of persons with mental illness who lice in institutions. Analyses indicates that nationwide, state protection and advocacy systems received an average of 9.03 complaints per 100,000 residents. Additional data is reported. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental illness
KW - residential care institutions
KW - abuse
KW - neglect
KW - civil rights violations
KW - statistics
KW - US
KW - 2002
KW - Abuse Reporting
KW - Civil Rights
KW - Mental Disorders
KW - Residential Care Institutions
KW - Statistics
KW - Health Care Services
KW - 2002
DO - 10.1176/appi.ps.53.5.535
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-13234-011&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3484-2663
UR -
UR - kevin.hennessy@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Homola, Jiřı
AU - Dostálek, Jakub
AU - Chen, Shengfu
AU - Rasooly, Avraham
AU - Jiang, Shaoyi
AU - Yee, Sinclair S.
T1 - Spectral surface plasmon resonance biosensor for detection of staphylococcal enterotoxin B in milk
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2002/05/05/
VL - 75
IS - 1/2
M3 - Article
SP - 61
SN - 01681605
AB - This work evaluates a newly developed wavelength modulation-based SPR biosensor for the detection of staphylococcal enterotoxin B (SEB) in milk. Two modes of operation of the SPR biosensor are described: direct detection of SEB and sandwich assay. In the sandwich assay detection mode, secondary antibodies are bound to the already captured toxin to amplify sensor response. Samples including SEB in buffer and SEB in milk were analyzed in this work. The SPR biosensor has been shown to be capable of directly detecting concentrations of SEB in buffer as low as 5 ng/ml. In sandwich detection mode, the lowest detection limit was determined to be 0.5 ng/ml for both buffer and milk samples. The reported wavelength modulation-based SPR sensor provides a generic platform which can be tailored for detection of various foodborne pathogens and agents for food analysis and testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIOLOGY
KW - Staphylococcal diseases
KW - Biosensors
KW - Milk
KW - Biosensor
KW - Staphylococcal enterotoxin B
KW - Surface plasmon resonance
N1 - Accession Number: 7765677; Homola, Jiřı 1; Email Address: homola@ee.washington.edu; Dostálek, Jakub 1; Chen, Shengfu 2; Rasooly, Avraham 3; Jiang, Shaoyi 2; Yee, Sinclair S. 1; Affiliations: 1: Department of Electrical Engineering, University of Washington, Box 352500 Seattle, WA, 98195, USA; 2: Department of Chemical Engineering, University of Washington, Seattle, WA, 98195-1750, USA; 3: US Food and Drug Administration, Division of Microbiological Studies, 200 C St. SW. HFS 515, Washington, DC, 20204, USA; Issue Info: May2002, Vol. 75 Issue 1/2, p61; Thesaurus Term: MICROBIOLOGY; Subject Term: Staphylococcal diseases; Subject Term: Biosensors; Subject Term: Milk; Author-Supplied Keyword: Biosensor; Author-Supplied Keyword: Staphylococcal enterotoxin B; Author-Supplied Keyword: Surface plasmon resonance; Number of Pages: 9p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Cha, Chang-Jun
AU - Cerniglia, Carl E.
T1 - Purification and characterization of an erythromycin esterase from an erythromycin-resistant Pseudomonas sp.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002/05/07/
VL - 210
IS - 2
M3 - Article
SP - 239
SN - 03781097
AB - An erythromycin esterase (molecular mass 51 200 Da) was purified from Pseudomonas sp. GD100, which was isolated from a salmon hatchery sediment sample from Washington State. The pI of the protein was 4.5–4.8. The enzyme was inhibited by 1 mM mercuric acid, and had the substrate specificity for structurally related 14-membered macrolides, which decreased in the order of oleandomycin, erythromycin A and erythromycin A enol ether. The activity for erythromycin A varied with temperature, but the effect of pH was minimal at pH 6.0–9.0. The half-life of the enzyme was estimated to be 8.9 h at 35°C and 0.23 h at 55°C, and the activation energy of the catalytic reaction of erythromycin A was estimated at 16.2 kJ mol−1. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aquaculture
KW - Erythromycin
KW - Erythromycin A
KW - Erythromycin A enol ether
KW - Mercuric chloride
KW - Oleandomycin
N1 - Accession Number: 7813997; Kim, Yong-Hak 1; Cha, Chang-Jun 1; Cerniglia, Carl E.; Email Address: ccerniglia@nctr.fda.gov]; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA; Issue Info: May2002, Vol. 210 Issue 2, p239; Thesaurus Term: Aquaculture; Subject Term: Erythromycin; Author-Supplied Keyword: Erythromycin A; Author-Supplied Keyword: Erythromycin A enol ether; Author-Supplied Keyword: Mercuric chloride; Author-Supplied Keyword: Oleandomycin; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rao, K. Murali Krishna
AU - Meighan, Terence
AU - Bowman, Linda
T1 - ROLE OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN THE PRODUCTION OF INFLAMMATORY MEDIATORS: DIFFERENCES BETWEEN PRIMARY RAT ALVEOLAR MACROPHAGES AND MACROPHAGE CELL LINES.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/05/21/
VL - 65
IS - 10
M3 - Article
SP - 757
EP - 768
SN - 15287394
AB - Stimulation of macrophages has been shown to activate all three families of mitogen activated protein kinases (MAPKs). However, variable results are reported in the literature with respect to the particular kinases activated with any given stimulus. In this study, the role of activation of MAPKs was examined in the production of inflammatory mediators by measuring the phosphorylation of the kinases and their ability to phosphorylate specific substrates in rat primary alveolar macrophages, a rat alveolar macrophage cell line (NR8383), and two mouse monocytic cell lines (RAW 264.7 and J774A.1). In the three cell lines examined, all three families of MAPKs were activated upon stimulation with either lipopolysaccharide (LPS) or LPS plus interferon-γ; in contrast, only ERK1/2 was activated in primary rat alveolar macrophages upon stimulation with LPS. Inhibition of ERK1/2 activation by the MEK inhibitor PD98059 abrogated nitric oxide and tumor necrosis factor-α (TNF-α) production in primary rat alveolar macrophages, but the p38 inhibitor SB203580 had no effect on the production of these two inflammatory mediators. These observations indicate that MAPK activation is cell specific and explain some of the conflicting results reported in the literature. These studies emphasize the need to exercise caution in extrapolating data from cell lines to primary cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enzyme activation
KW - Inflammation -- Mediators
KW - Mitogens
N1 - Accession Number: 6677478; Rao, K. Murali Krishna 1; Meighan, Terence 1; Bowman, Linda 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: 2002, Vol. 65 Issue 10, p757; Thesaurus Term: Enzyme activation; Subject Term: Inflammation -- Mediators; Subject Term: Mitogens; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/00984100290071027
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Kenney, Richard T.
AU - Regina Rabinovich, N.
AU - Pichyangkul, Sathit
AU - Price, Virginia L.
AU - Engers, Howard D.
T1 - 2nd meeting on novel adjuvants currently in/close to human clinical testing: World Health Organization—Organization Mondiale de la Sante´ Fondation Me´rieux, Annecy, France, 5–7 June 2000
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/22/
VL - 20
IS - 17/18
M3 - Proceeding
SP - 2155
SN - 0264410X
KW - Human clinical trials
KW - Novel adjuvants
KW - Preclinical testing
KW - Review
KW - Vaccine
N1 - Accession Number: 7803576; Kenney, Richard T. 1; Regina Rabinovich, N. 2; Pichyangkul, Sathit 3; Price, Virginia L. 4; Engers, Howard D. 4; Email Address: engersh@who.ch; Affiliations: 1: US Food and Drug Administration/CBER, Bethesda, MD, USA; 2: Malaria Vaccine Initiative/PATH, Rockville, MD, USA; 3: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; 4: UNDP/World Bank, WHO Special Programme of Research and Training in Tropical Diseases, Avenue Appia 20, CH-1211, Geneva 27, Switzerland; Issue Info: May2002, Vol. 20 Issue 17/18, p2155; Author-Supplied Keyword: Human clinical trials; Author-Supplied Keyword: Novel adjuvants; Author-Supplied Keyword: Preclinical testing; Author-Supplied Keyword: Review; Author-Supplied Keyword: Vaccine; Number of Pages: 9p; Document Type: Proceeding
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ER -
TY - JOUR
AU - Barbour, E.K.
AU - Abdelnour, A.
AU - Jirjis, F.
AU - Faroon, O.
AU - Farran, M.T.
T1 - Evaluation of 12 stabilizers in a developed attenuated Salmonella Enteritidis vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/22/
VL - 20
IS - 17/18
M3 - Article
SP - 2249
SN - 0264410X
AB - The development of a stable live attenuated Salmonella Enteritidis (SE) vaccine, resisting heat stress during transportation and storage in unequipped tropical and subtropical zones of the world, is highly recommended. Twelve stabilizers were individually supplemented into a 9 ml volume of sterile distilled water resulting in concentrations of 1, 2, 3, 4 and 5%. A volume of 1 ml of attenuated live SE vaccine is added over the 9 ml of each concentration of the stabilizers. The differently stabilized SE vaccines were stressed at 55 °C for 48 h. The lowest percent reductions in SE cell viability by specified level of each stabilizer in ascending order were: 22.3% by 2% skim milk, 55.1% by 5% bovine serum albumin (BSA), 59.2% by 4% sorbitol, 74.4% by 3% maltose, 75% by 2% honey, 91.3% by 3% histidine, 96.9% by 1% heparin, 97.5% by 4% dextrose, 97.9% by 5% lactose, 99.4% by 5% sucrose, 99.5% by 2% gelatin, and 100% by 1–5% glycerol. In narrowing the concentration levels of skim milk to include 1.00, 1.25, 1.50, 1.75, 2.00, 2.25, 2.50, 2.75, and 3.00%, the 2.50% was the optimum level resulting in minimal percent reduction in SE cell viability of 18.9% after exposure to the defined heat stress. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella enteritidis
KW - Bacterial vaccines
KW - Live vaccine
KW - Salmonella Enteritidis
KW - Stabilizers
N1 - Accession Number: 7803589; Barbour, E.K. 1; Email Address: eb01@aub.edu.lb; Abdelnour, A. 2; Jirjis, F. 3; Faroon, O. 4; Farran, M.T. 1; Affiliations: 1: Department of Animal Science, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon; 2: Department of Animal Science, Faculty of Agricultural Sciences, The Holy Spirit University, Kaslik, Lebanon; 3: Intervet Inc., Millsboro, DE, USA; 4: United States Public Health Service, Centers for Disease Control, Atlanta, GA, USA; Issue Info: May2002, Vol. 20 Issue 17/18, p2249; Subject Term: Salmonella enteritidis; Subject Term: Bacterial vaccines; Author-Supplied Keyword: Live vaccine; Author-Supplied Keyword: Salmonella Enteritidis; Author-Supplied Keyword: Stabilizers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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ER -
TY - JOUR
AU - McKinzie, Page B.
AU - Parsons, Barbara L.
T1 - Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2002/05/27/
VL - 517
IS - 1/2
M3 - Article
SP - 209
SN - 13835718
AB - Allele-specific competitive blocker PCR (ACB-PCR) is a sensitive allele-specific amplification method in which preferential amplification of the mutant allele occurs by using a primer that has more mismatches to the wild-type allele than to the mutant allele (mutant-specific primer, MSP). Additionally, a non-extendable primer with more mismatches to the mutant allele than to the wild-type allele (blocker primer, BP) competes with the MSP for binding to the wild-type allele, thereby reducing background amplification from the wild-type allele. ACB-PCR primer design is largely dependent upon the basepair substitution being measured, making it unclear if this method is broadly applicable. In an earlier study, an H-ras codon 61 CAA→AAA mutation had been detected by ACB-PCR at a sensitivity of 10−5. In this study, ACB-PCR was applied to two human K-ras codon 12 mutations: GGT→GTT and GGT→GAT . The method was optimized by systematically altering the concentrations of Perfect Match PCR Enhancer, MSP, BP, and dNTPs. For each mutation, mutant fractions as low as 10−5 were detected, indicating that this assay can be used on a variety of base substitution mutations. In addition, the results suggest that the 3′-terminal mismatches between the MSP and wild-type allele may be used to predict the ACB-PCR conditions that will be appropriate for the detection of other base substitution mutations. The range of concentrations for each of these components is narrow, making this method relatively easy to apply to additional mutational targets. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Polymerase chain reaction
KW - Alleles
KW - ACB-PCR
KW - Allele-specific amplification
KW - Basepair substitution
KW - K-ras
KW - Mutation detection
N1 - Accession Number: 7814704; McKinzie, Page B.; Email Address: pmckinzie@nctr.fda.gov; Parsons, Barbara L. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, HFT-120, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA; Issue Info: May2002, Vol. 517 Issue 1/2, p209; Thesaurus Term: Mutation (Biology); Subject Term: Polymerase chain reaction; Subject Term: Alleles; Author-Supplied Keyword: ACB-PCR; Author-Supplied Keyword: Allele-specific amplification; Author-Supplied Keyword: Basepair substitution; Author-Supplied Keyword: K-ras; Author-Supplied Keyword: Mutation detection; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wheeler, John S.
AU - Chou, Selene
T1 - Considerations and procedures in the derivation of ATSDR minimal risk levels
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/31/5/31/2002 Supplement
VL - 20
M3 - Article
SP - S51
SN - 0264410X
AB - Minimal risk levels (MRLs) are health-based guidance values derived for individual substances by conducting a thorough review of the literature, identifying appropriate target organs of response, and identifying a dose level where a no adverse effect or the lowest adverse effect level is seen. This level is then evaluated for uncertainty in the data base and for other extenuating factors and subsequently adjusted with uncertainty or modifying factors. The resulting calculation yields the MRL that is defined as an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure. Typically, MRLs are derived for different durations of exposure (acute, intermediate, chronic) and for different routes of exposure (oral, inhalation). The MRLs serve as useful reference values in evaluating human health from exposure to substances found at hazardous waste sites. Because of numerous requests of various programs, recent work has focused on expanding the applicability of MRLs to other situations and routes of exposure (dermal, food supply, intramuscular) beyond the traditional oral and inhalation exposure routes at waste sites. Results of work, in conjunction with the Agency for Toxic Substances and Disease Registry’s computational toxicology laboratory, shows that the use of computational methods, such as physiologically based pharmacokinetic modeling, may allow the MRL process to be adapted to unique durations and routes of exposure such as intramuscular injections. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Reference values (Medicine)
KW - Uncertainty
KW - Minimal risk level
KW - Reference dose
KW - Uncertainty factor
N1 - Accession Number: 7820538; Wheeler, John S.; Email Address: jzw1@cdc.gov; Chou, Selene 1; Affiliations: 1: US Department of Health and Human Services Public Health Services, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Atlanta, GA, USA; Issue Info: 5/31/2002 Supplement, Vol. 20, pS51; Subject Term: Reference values (Medicine); Subject Term: Uncertainty; Author-Supplied Keyword: Minimal risk level; Author-Supplied Keyword: Reference dose; Author-Supplied Keyword: Uncertainty factor; Number of Pages: 0p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McCANLIES, ERIN
AU - LANDSITTEL, DOUGLAS P.
AU - YUCESOY, BERRAN
AU - VALLYATHAN, VAL
AU - LUSTER, MICHAEL L.
AU - SHARP, DAN S.
T1 - Significance of Genetic Information in Risk Assessment and Individual Classification Using Silicosis as a Case Model.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/06//
VL - 46
IS - 4
M3 - Article
SP - 375
EP - 381
SN - 00034878
AB - Over the last decade the role of genetic data in epidemiological research has expanded considerably. We recently published a case–control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1α (IL-1α), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor α (TNFα) as risk factors associated with silicosis, a fibrotic lung disease. In contrast, this report uses data generated from these studies to illustrate the utility of genetic information for the purposes of risk assessment and clinical prediction. Specifically, this study will address how, given a known exposure, genetic information affects the characterization of risk groups. Relative operating characteristic (ROC) curves were then used to determine the impact of genetic information on individual classification. Logistic regression modeling procedures were used to estimate the predicted probability of developing silicosis. This probability was then used to construct predicted risk deciles, first for a model with occupational exposure only and then for a model containing occupational exposure and genetic main effects and interactions. Results indicate that the exposure-only model effectively captures an increasing relationship between predicted risk deciles and prevalence of observed silicosis cases. Individuals comprising the highest risk decile were almost four times as likely to have silicosis as opposed to the lowest risk decile. The addition of genetic data, however, substantially improved characterization of risk categories; the proportion of cases in the highest risk decile was almost eight times that in the lowest risk decile. However, the ROC curve and classification analysis demonstrated that the addition of genetic main effects and interactions did not significantly impact on prediction of the individual’s case status. These results indicate that genetic information plays a valuable role in effectively characterizing risk groups and mechanisms of disease operating in a substantial proportion of the population. However, in the case of fibrotic lung disease caused by silica exposure, information about the presence or absence of the minor variants of IL-1α, IL-1RA and TNFα is unlikely to be a useful tool for individual classification. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Epidemiology
KW - Biometry
KW - Toxicology
KW - Silicosis
KW - Interleukins
KW - Lung diseases
KW - epidemiology
KW - genetics
KW - occupational safety and health
KW - risk assessment
KW - silicosis
N1 - Accession Number: 44400175; McCANLIES, ERIN 1; Email Address: eim4@cdc.gov; LANDSITTEL, DOUGLAS P. 1; YUCESOY, BERRAN 2,3; VALLYATHAN, VAL 4; LUSTER, MICHAEL L. 2; SHARP, DAN S. 1; Affiliations: 1: Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; 3: Ankara University, School of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey; 4: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Jun2002, Vol. 46 Issue 4, p375; Thesaurus Term: Risk assessment; Thesaurus Term: Epidemiology; Thesaurus Term: Biometry; Thesaurus Term: Toxicology; Subject Term: Silicosis; Subject Term: Interleukins; Subject Term: Lung diseases; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: genetics; Author-Supplied Keyword: occupational safety and health; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: silicosis; Number of Pages: 7p; Document Type: Article
L3 - 10.1093/annhyg/mef055
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ER -
TY - JOUR
AU - Birch, M. Eileen
T1 - Occupational Monitoring of Particulate Diesel Exhaust by NIOSH Method 5040.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 400
EP - 405
PB - Taylor & Francis Ltd
SN - 1047322X
AB - NMAM 5040 is a particulate carbon method based on a thermal-optical analysis technique. The method was evaluated and published as a method for monitoring occupational exposures to particulate diesel exhaust, but it is applicable to particulate carbon aerosols in general, and has been routinely used in both occupational and environmental settings. Both organic and elemental carbon are determined, but EC is a more selective measure of workplace diesel exposure. In previous studies, good agreement between TC results obtained by different methods has been achieved, but the OC-EC results for different methods have been quite variable. Although a reference material is not currently available to test the accuracy of different methods, previous studies indicate that purely thermal methods are subject to positive bias from organic materials that char. Charring and inadequate removal of refractory OC components during the nonoxidative mode (typically 550°C in nitrogen) likely explain the positive bias of thermal methods, as well as the large variability across methods. These interferences may be negligible in some cases (e.g., samples from mines), but they present significant biases in others (e.g., urban air samples, samples containing wood or cigarette smokes). Good intefiaboratory agreement was obtained in a round robin comparison between six laboratories that used NMAM 5040, which was not the case with purely thermal methods. Good agreement has also been seen in smaller-scale comparisons conducted for quality assurance purposes. Until a suitable reference material becomes available, such comparisons are recommended as part of a laboratory's QA procedures. At present, five commercial laboratories (4 in the United States and 1 in Canada) perform the 5040 analysis, and over 40 instruments are in use globally for environmental and occupational monitoring. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel motor exhaust gas
KW - Air pollution
KW - Industrial hygiene
KW - Health
N1 - Accession Number: 6632312; Birch, M. Eileen 1; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Mailstop R-7, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.; Issue Info: Jun2002, Vol. 17 Issue 6, p400; Thesaurus Term: Diesel motor exhaust gas; Thesaurus Term: Air pollution; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/10473220290035390
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DB - eih
ER -
TY - JOUR
AU - Daniels, William
AU - Miller, Aubrey
T1 - I-BEAM—An Innovative Building Air Quality Software Tool.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 406
EP - 408
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Features the Indoor Air Quality Building Education and Assessment Model, a software for managing indoor air quality problems in buildings. Key features and specifications; Availability information; Key industrial applications.
KW - Industrial hygiene
KW - Air quality management -- Software
N1 - Accession Number: 6632311; Daniels, William 1; Miller, Aubrey; Affiliations: 1: U.S. Public Health Service Region VIII, 1961 Stout Street, Denver, CO 80294-3538; Issue Info: Jun2002, Vol. 17 Issue 6, p406; Thesaurus Term: Industrial hygiene; Subject Term: Air quality management -- Software; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10473220290035408
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TY - JOUR
AU - Gao, Pengfei
AU - Martin, Jennifer
T1 - Volatile Metabolites Produced by Three Strains of Stachybotrys chartarum Cultivated on Rice and Gypsum Board.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 430
EP - 436
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Stachybotrys chartarum (atra) is a toxigenic fungus frequently found in water-damaged buildings. Although microbial volatile organic compounds (MVOCs) produced by Aspergillus, Penicillium, and other fungi have been investigated extensively, little information exists on what MVOCs can be produced by S. chartarum. In this study, three strains of S. chartarum isolated from water-damaged residential homes in Cleveland, Ohio, were cultivated on rice and gypsum board. Air samples were collected after one, two, three, four, and six weeks of cultivation using Tenax TA tubes. Unique MVOCs were determined and other alcohols, ketones, and terpenes were also investigated using gas chromatography/mass spectrometry after thermal desorption from the sampling tube. Four unique MVOCs, 1-butanol, 3-methyl-1-butanol, 3-methyl-2-butanol, and thujopsene, were detected on rice cultures, and only one of them (1-butanol) was detected on gypsum board cultures. For a given strain, volatiles were considerably different with different cultivation media. Concentration profiles of the volatile compounds varied among compounds; however,each compound exhibited corresponding concentration trends between the strains. In comparison with our previous studies of five Aspergillus species on gypsum board under the same experimental conditions, fewer unique MVOCs were produced by S. chartarum, and they were quite different. It thus may be possible to use marker-unique MVOCs as a fingerprint to distinguish fungi in indoor environments once enough information becomes available. Our findings also indicate that volatiles produced by S. chartarum may represent a relatively small fraction of the total volatiles present in problem buildings where Aspergillus spp., Penicillium spp., and other fungi usually coexist. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metabolites
KW - Industrial hygiene
KW - Stachybotrys
KW - Cultures
KW - Fungi
KW - Stachybotrys atra
KW - Stachybotrys chartarum
KW - UNIQUE MVOCS
KW - VOLATILE METABOLITES
KW - WATER-DAMAGED BUILDINGS
N1 - Accession Number: 6632306; Gao, Pengfei 1; Martin, Jennifer 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Jun2002, Vol. 17 Issue 6, p430; Thesaurus Term: Metabolites; Thesaurus Term: Industrial hygiene; Subject Term: Stachybotrys; Author-Supplied Keyword: Cultures; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Stachybotrys atra; Author-Supplied Keyword: Stachybotrys chartarum; Author-Supplied Keyword: UNIQUE MVOCS; Author-Supplied Keyword: VOLATILE METABOLITES; Author-Supplied Keyword: WATER-DAMAGED BUILDINGS; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/10473220290035462
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SAXENA, R. K
AU - WEISSMAN, D
AU - SAXENA, Q. B
AU - SIMPSON, J
AU - LEWIS, D. M
T1 - Kinetics of changes in lymphocyte sub-populations in mouse lungs after intrapulmonary infection with M. bovis (Bacillus Calmette-Guerin) and identity of cells responsible for IFNγ responses.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2002/06//
VL - 128
IS - 3
M3 - Article
SP - 405
EP - 410
SN - 00099104
AB - SUMMARY Gamma interferon (IFNγ) plays a key role in host defense against pulmonary mycobacterial infections. A variety of lymphocyte subsets may participate in producing pulmonary IFNγ responses, but their relative contributions after mycobacterial infection have not been clearly elucidated. To address this question, C57Bl/6 female mice were infected by intrapulmonary instillation of 2·5 × 104 BCG (Mycobacterium bovis Bacillus Calmette-Guerin). Lymphocyte populations in lung interstitium were examined at different time points after the infection. BCG load in lungs peaked between 4 and 6 weeks post-infection and declined to very low levels by the 12th week of infection. Recovery of lung interstitial lymphocytes doubled by 4–6 weeks after infection and declined thereafter. Flow cytometric analysis of the lung-derived lymphocytes revealed that about 5% of the these cells made IFNγ in control mice, and this baseline IFNγ production involved T (CD3+ NK1.1- ), NK (CD3- NK1.1+ ) and NKT (CD3+ NK1.1+ ) cells. As the BCG lung infection peaked, the total number of CD3+ T cells in the lungs increased threefold at 5–6 weeks post-infection. There was a marked increase (sixfold) in the number of T cells secreting IFNγ 5–6 weeks post-infection. Some increase was also noted in the NKT cells making IFNγ, but the numbers of NK cells making IFNγ in BCG-infected lungs remained unaltered. Our results suggest that whereas NK and NKT cells contribute to baseline IFNγ secretion in control lungs, expansion in the IFNγ-producing T-cell population was essentially responsible for the augmented response seen in lungs of BCG-infected mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - MYCOBACTERIAL diseases
KW - LYMPHOCYTES
KW - BCG infection
KW - host
KW - Interferon-gamma
KW - mice
KW - resistance models
KW - T cells
N1 - Accession Number: 6814290; SAXENA, R. K 1; WEISSMAN, D 2; SAXENA, Q. B 3; SIMPSON, J 2; LEWIS, D. M 3; Source Information: Jun2002, Vol. 128 Issue 3, p405; Subject: INTERFERONS; Subject: MYCOBACTERIAL diseases; Subject: LYMPHOCYTES; Author-Supplied Keyword: BCG infection; Author-Supplied Keyword: host; Author-Supplied Keyword: Interferon-gamma; Author-Supplied Keyword: mice; Author-Supplied Keyword: resistance models; Author-Supplied Keyword: T cells; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2249.2002.01839.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Norton, Susan B.
AU - Cormier, Susan M.
AU - Smith, Marc
AU - Jones, R. Christian
AU - Schubauer-Berigan, Mary
T1 - PREDICTING LEVELS OF STRESS FROM BIOLOGICAL ASSESSMENT DATA: EMPIRICAL MODELS FROM THE EASTERN CORN BELT PLAINS, OHIO, USA.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2002/06//
VL - 21
IS - 6
M3 - Article
SP - 1168
EP - 1175
SN - 07307268
AB - Interest is increasing in using biological community data to provide information on the specific types of anthropogenic influences impacting streams. We built empirical models that predict the level of six different types of stress with fish and benthic macroinvertebrate data as explanatory variables. Significant models were found for six stressor factors: stream corridor structure; siltation; total suspended solids (TSS), biochemical oxygen demand (BOD), and iron (Fe); chemical oxygen demand (COD) and BOD; zinc (Zn) and lead (Pb); and nitrate and nitrite (NOx) and phosphorus (P). Model R² values were lowest for the siltation factor and highest for TSS, BOD, and Fe. Model R² values increased when spatial relationships were incorporated into the model. The models generally performed well when applied to a random subset of the data. Performance was more mixed when models were applied to data collected from a previous time period, perhaps because of a change in the spatial structure of these systems. These models may provide a useful indication of the levels of different stresses impacting stream reaches in the Eastern Corn Belt Plains ecoregion of Ohio, USA. More generally, the models provide additional evidence that biological communities can serve as useful indicators of the types of anthropogenic stress impacting aquatic systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biotic communities
KW - Rivers
KW - Chemical oxygen demand
KW - Effect of human beings on fishes
KW - Water pollution
KW - Fish
KW - Macroinvertebrates
KW - Multivariate regression
KW - Spatial autocorrelation
KW - Streams
N1 - Accession Number: 22126073; Norton, Susan B. 1; Email Address: norton.susan@epa.gov; Cormier, Susan M. 2; Smith, Marc 3; Jones, R. Christian 4; Schubauer-Berigan, Mary 5; Affiliations: 1: U.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460; 2: U.S. Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, Ohio 45268; 3: Ohio Environmental Protection Agency, Ecological Assessment Section, Groveport, Ohio 43125, USA; 4: George Mason University, Department of Environmental Science and Policy, Fairfax, Virginia 22030, USA; 5: National Institute for Occupational Safety and Health, Department of Health and Human Services, Cincinnati, Ohio 45213, USA; Issue Info: Jun2002, Vol. 21 Issue 6, p1168; Thesaurus Term: Biotic communities; Thesaurus Term: Rivers; Thesaurus Term: Chemical oxygen demand; Thesaurus Term: Effect of human beings on fishes; Thesaurus Term: Water pollution; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Macroinvertebrates; Author-Supplied Keyword: Multivariate regression; Author-Supplied Keyword: Spatial autocorrelation; Author-Supplied Keyword: Streams; Number of Pages: 8p; Illustrations: 11 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Litton, Charles D.
T1 - The use of light scattering and ion chamber responses for the detection of fires in diesel contaminated atmospheres
JO - Fire Safety Journal
JF - Fire Safety Journal
Y1 - 2002/06//
VL - 37
IS - 4
M3 - Article
SP - 409
SN - 03797112
AB - Experiments were conducted to determine the optical scattering properties of diesel particulate matter (DPM) and various combustion aerosols from both flaming and smoldering combustion sources at discrete angles of 15° and 30° in the forward direction and at a light source wavelength of 635 nm using a simple light scattering module. In addition to the scattering data, simultaneous measurements were made of the total aerosol mass concentration; light extinction at an average wavelength of 546 nm; and the response of a common bipolar ion chamber typical of residential smoke detectors modified to allow the aerosols to flow through the chamber. The results of these experiments indicate, for DPM and combustion aerosols, the intensities per unit mass concentration depend not only upon whether the aerosol is DPM or combustion aerosol but also upon the type of combustion aerosol. The results also indicate that the ion chamber responses are greatest for DPM, followed by the response to flaming combustion aerosols (FCA) and lowest for smoldering combustion aerosols (SCA). For light scattering, the greatest intensities are found for SCA, followed by the intensities from FCA, and lowest for DPM. This report describes the experiments, their results, and the use of these results to develop design criteria for early warning fire sensors capable of the rapid and reliable detection of fires in atmospheres that may or may not be contaminated by the products produced from diesel engines. [Copyright &y& Elsevier]
AB - Copyright of Fire Safety Journal is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Light -- Scattering
KW - Ionization chambers
N1 - Accession Number: 8800069; Litton, Charles D. 1; Email Address: chl3@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Center, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Jun2002, Vol. 37 Issue 4, p409; Subject Term: Light -- Scattering; Subject Term: Ionization chambers; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104728828
T1 - Translating research into practice: the future ahead.
AU - Farquhar, Cynthia M
AU - Stryer, Daniel
AU - Slutsky, Jean
Y1 - 2002/06//
N1 - Accession Number: 104728828. Language: English. Entry Date: 20110610. Revision Date: 20161117. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9434628.
KW - Medical Practice, Evidence-Based
KW - Health Services Research -- Methods
KW - Research Support
KW - Financing, Government
KW - Forecasting
KW - Health Services Research -- Economics
KW - Human
KW - Pilot Studies
KW - Practice Guidelines
KW - Quality Assurance
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 233
EP - 249
JO - International Journal for Quality in Health Care
JF - International Journal for Quality in Health Care
JA - INT J QUAL HEALTH CARE
VL - 14
IS - 3
PB - Oxford University Press / USA
AB - Objective: To summarize and analyze the focus and methodologies of the Translating Research into Practice (TRIP) projects funded in 1999-2000 by the US Agency for Healthcare Research and Quality (AHRQ).Data Sources and Study Design: An analysis of the successful applications for the TRIP I and II requests for applications in 1999 and 2000 was produced from the data collected.Data Collection: The following items were abstracted from each of the successful applications: provider focus, patient population, vulnerable populations, methodologies, interventions for change, outcomes measured, and conceptual framework used.Principal Findings: AHRQ funded 27 TRIP grants in 1999 and 2000. A wide variety of health care providers, settings, and patients were the target of the grants. The most common study design was a randomized controlled trial. The most common TRIP interventions were educational and the most common frameworks were either adult learning theory or organizational theory. More than half of the projects planned to use information technology and half the projects had a focus on reducing errors.Conclusions: The TRIP projects encompass a broad range of providers, environments, patients, and interventions. The field of applied research and quality improvements should be considerably enhanced by these research projects.
SN - 1353-4505
AD - Center for Practice Technology Assessment, Agency for Healthcare Research and Quality, Rockville, MD, USA. c.farquhar@auckland.ac.nz
U2 - PMID: 12108534.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822627
T1 - Clinical pharmacology of antimicrobial use in humans and animals.
AU - Lathers CM
Y1 - 2002/06//
N1 - Accession Number: 105822627. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Antibiotics -- Therapeutic Use
KW - Animals
KW - Antibiotics -- Pharmacokinetics
KW - Drug Design
KW - Drug Resistance, Microbial
KW - Ecosystem
KW - Food Microbiology
KW - Intestines -- Microbiology
KW - Public Health
KW - Safety
KW - Water Microbiology
SP - 587
EP - 600
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Veterinary public health is a frontier in the fight against human disease, charged to control and eradicate zoonotic diseases that are naturally transmitted between vertebrate animals and man. Currently there is a need for clinical pharmacologists and all health care givers to limit the development of bacterial resistance in humans to contain the increased health care expenditures related to morbidity and mortality associated with the use of antimicrobials. The development of resistance predates the use of antibiotics and will always be a problem to the successful treatment of patients. Ongoing discussion debates the extent to which antibiotic use in animals contributes to the development of antibiotic resistance in humans. The veterinary use ofantibiotics as antimicrobial growth promoters is thought to influence the prevalence of resistance in animal bacteria and to be a risk factor for the emergence of antibiotic resistance in human pathogens. Transfer of antibiotic resistant bacteria from animals to humans may occur via contact, including occupational exposure and via the food chain. Resistance genes may transferfrom bacteria of animals to human pathogens in the intestinal flora of humans. Prevention of the development of resistance in humans necessitates good animal husbandry and hygienic measures to prevent cross contamination and a decrease in the use of antibiotics. Appropriate use of antibiotics for food animals will preserve the long-term efficacy of existing antibiotics, support animal health and welfare, and limit the risk of transfer of antibiotic resistance to humans. Investigators must also develop new antimicrobial agents. Poole (J Pharmacy Pharmacol 2001;53:283) recommends targeting the three predominate mechanisms of development of resistance by antimicrobials (i.e., antibiotic inactivation, target site modification, and altered uptake via restricted entry and/or enhanced efflux) to specifically complement the development of novel agents with novel bacterial targets. Bacterial resistance and its selection may be evaluated by comparing the relationship to antibiotic pharmacokinetic (PK) values obtained from serum concentrations and organism MICs (minimum inhibitory concentrations; concentration-dependent killing) to reveal culture and sensitivity tests in patients. Pharmacodynamic (PD) models may be developed to identify factors associated with the probability that bacterial resistance will develop. Thomas et al (Antimicrobial Agents Chemotherapy 1998;42:521) used this combined approach of PK/PD and MICs to examine data retrospectively. The role of clinical pharmacology is to work with PK/PD models such as these to determine the best use of antibiotics in humans to minimize the development of resistance. The role of any regulatory body responsible for the protection of the public health and food safety for consumers is to assess risk and to then communicate and manage the risk. Scientific uncertainty must be interpreted to propose sound policy options. The conversion of sound science into an appropriate regulatory policy to protect the public health is most important.
SN - 0091-2700
AD - Center of Veterinary Medicine, US Food and Drug Administration, Rockville, MD 20855, USA.
U2 - PMID: 12043947.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822633
T1 - A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals.
AU - Martinez MN
AU - Amidon GL
Y1 - 2002/06//
N1 - Accession Number: 105822633. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Intestinal Absorption
KW - Pharmacokinetics
KW - Proteins
KW - Biological Availability
KW - Carrier Proteins -- Physiology
KW - Diffusion
KW - Food
KW - Glycoproteins -- Physiology
KW - Lipid Metabolism, Inborn Errors
KW - Solubility
SP - 620
EP - 643
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - This article provides an overview of the patient-specific and drug-specific variables that can affect drug absorption following oral product administration. The oral absorption of any chemical entity reflects a complex spectrum of events. Factors influencing product bioavailability include drug solubility, permeability, and the rate of in vivo dissolution. In this regard, the Biopharmaceutics Classification System has proven to be an important tool for predicting compounds likely to be associated with bioavailability problems. It also helps in identifying those factors that may alter the rate and extent of drug absorption. Product bioavailability can also be markedly influenced by patient attributes such as the integrity of the gastrointestinal tract, physiological status, site of drug absorption, membrane transporters, presystemic drug metabolism (intrinsic variables), and extrinsic variables such as the effect of food or concomitant medication. Through an awareness of a drug's physicochemical properties and the physiological processes affecting drug absorption, the skilled pharmaceutical scientist can develop formulations that will maximize product availability. By appreciating the potential impact of patient physiological status, phenotype, age, gender, and lifestyle, dosing regimens can be tailored to better meet the needs of the individual patient.
SN - 0091-2700
AD - Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20855, USA.
U2 - PMID: 12043951.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - INTEGRATING CULTURAL VARIABLES INTO DRUG ABUSE PREVENTION AND TREATMENT WITH RACIAL/ETHNIC MINORITIES.
AU - Castro, Felipe González
AU - Alarcón, Eduardo Hernández
JO - Journal of Drug Issues
JF - Journal of Drug Issues
Y1 - 2002///Summer2002
VL - 32
IS - 3
SP - 783
EP - 810
SN - 00220426
N1 - Accession Number: 7511607; Author: Castro, Felipe González: 1 Author: Alarcón, Eduardo Hernández: 2 ; Author Affiliation: 1 Professor of Clinical Psychology, Department of Psychology, Arizona State University: 2 Division of State and Community Systems Development, Center for Substance Abuse Prevention; No. of Pages: 28; Language: English; Publication Type: Article; Update Code: 20060606
N2 - A set of variables, identified as “cultural variables,” is introduced as important descriptors of the life experiences of people from the major ethnic/racial minority groups in the United States. It is stated that most contemporary models for prevention and treatment of substance abuse are “culturally blind” to the effects of these cultural variables on the risk of substance abuse among racial/ethnic minority people. Accordingly, a viable strategy for culturally relevant research and program design is to integrate these cultural variables into extant models to create culturally rich models for research as well as for the development of prevention and treatment programs. The use of “model programs” is discussed in regard to the competing aims of maintaining program fidelity while also making cultural adaptations to these model programs to make them more culturally relevant. Strategies and recommendations are presented for integrating cultural variables into prevention and treatment programs that purport to serve racial/ethnic minority people. ABSTRACT FROM AUTHOR
KW - *DRUG abuse -- Prevention
KW - *DRUG abuse -- Treatment
KW - *SUBSTANCE abuse -- Treatment
KW - RACIAL minorities
KW - ETHNICITY
KW - CULTURE
KW - RESEARCH
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Gray, Bradley M.
AU - Selden, Thomas M.
T1 - ADVERSE SELECTION AND THE CAPPED PREMIUM SUBSIDY IN THE FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM.
JO - Journal of Risk & Insurance
JF - Journal of Risk & Insurance
Y1 - 2002/06//
VL - 69
IS - 2
M3 - Article
SP - 209
EP - 224
PB - Wiley-Blackwell
SN - 00224367
AB - This article examines the relationship between adverse selection and the capped premium subsidy in the Federal Employees Health Benefit Program (FEHBP). Understanding this relationship is important, not only because the FEHBP is the largest employer-sponsored health program in the United States, but also because it has been proposed as a market-based model for the reform of both Medicare and the market for nongroup private coverage. We present a theoretical model of the FEHBP that we then test using enrollee data. In particular, we exploit the natural experiment that arises from variation in the premium subsidy cap across Metropolitan Statistical Areas (MSAs). Although the nominal subsidy cap is constant across MSAs, its real value varies greatly across MSAs with different price levels. The empirical analysis herein supports the contention that the premium subsidy in the FEHBP helps reduce adverse selection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Risk & Insurance is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE
KW - MEDICARE fraud
KW - INSURANCE premiums
KW - PUBLIC health -- United States
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 6719939; Gray, Bradley M. 1; Selden, Thomas M. 2; Affiliations: 1: Institute for Government and Public Affairs and School of Public Health/Division of Health Policy and Administration, University of Illinois at Chicago.; 2: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality.; Issue Info: Jun2002, Vol. 69 Issue 2, p209; Thesaurus Term: MEDICARE; Thesaurus Term: MEDICARE fraud; Thesaurus Term: INSURANCE premiums; Subject Term: PUBLIC health -- United States; Subject Term: MEDICAL policy; Subject: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 16p; Illustrations: 5 Diagrams, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - DE VEAU, I. F
AU - PEDERSOLI, W
AU - CULLISON, R
AU - BAKER, J
T1 - Pharmacokinetics of phenylbutazone in beef steers.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2002/06//
VL - 25
IS - 3
M3 - Article
SP - 195
EP - 200
SN - 01407783
AB - De Veau, I. F., Pedersoli, W., Cullison R., Baker J. Pharmacokinetics of phenylbutazone in beef steers. J. vet. Pharmacol. Therap. 25, 195–200. Phenylbutazone was administered intravenously to a group of 11 beef steers at a dosage of 6 mg/kg of body weight. Whole plasma and protein-free plasma were analyzed for phenylbutazone residues. Pharmacokinetic parameters of total and free phenylbutazone in plasma were calculated using a noncompartmental method. In regards to whole plasma data, the mean volume of distribution at steady state (V ss ), was 140 mL/kg body weight, with a mean (±SEM) terminal elimination half-life (t 1/2 ) of 34 ± 9 h. The mean clearance was 3.2 mL/h/kg body weight. The V ss , as determined from the protein-free plasma fraction, was 54093 mL/kg body weight. This larger V ss of free phenylbutazone compared with total plasma phenylbutazone was attributed to a high degree of plasma protein binding, as well as the greater penetration of free phenylbutazone into tissues. The mean t 1/2 of free phenylbutazone was 35 ± 12 h. This similarity to the t 1/2 estimated from total plasma phenylbutazone data is attributed to an equilibrium between free and plasma phenylbutazone during the terminal elimination phase. The pharmacokinetic parameters of free and total plasma phenylbutazone in beef steers are statistically similar to those previously reported for lactating dairy cows. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-inflammatory agents
KW - VETERINARY drugs
KW - PHARMACOKINETICS
KW - VETERINARY pharmacology
N1 - Accession Number: 6871934; DE VEAU, I. F 1,2; PEDERSOLI, W 3; CULLISON, R 3; BAKER, J 4; Source Information: Jun2002, Vol. 25 Issue 3, p195; Subject: ANTI-inflammatory agents; Subject: VETERINARY drugs; Subject: PHARMACOKINETICS; Subject: VETERINARY pharmacology; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2885.2002.00406.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - MARTINEZ, M
AU - LANGSTON, C
AU - MARTIN, T
AU - CONNER, D
T1 - Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2002/06//
VL - 25
IS - 3
M3 - Article
SP - 201
EP - 220
SN - 01407783
AB - Martinez M., Langston C., Martin T., Conner D. Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective. J. vet. Pharmacol. Therap. 25, 201–220. The Generic Animal Drug Patent Term Restoration Act (GADPTRA) enacted in 1988 provided the same benefits to animal drug products that were granted to human generic products. It has been over 13 years since the GADPTRA was enacted, and veterinary drug sponsors and regulators have gained enormous insight and experience into some of the unique challenges associated with the determination of product bioequivalence for veterinary dosage forms. Moreover, advances in information and technology have opened both new issues that must be addressed and new mechanisms for demonstrating product bioequivalence. While many aspects of the existing Center for Veterinary Medicine Bioequivalence Guidance continue to provide invaluable guidance to the animal drug industry, there are also aspects of this guidance that are being called into question. Therefore, during the 2001 annual meeting of the American Academy of Veterinary Pharmacology and Therapeutics, participants were asked to address issues and concerns associated with the evaluation of veterinary product bioequivalence. This manuscript provides a summary of the concerns and discussions that transpired. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY drugs
KW - VETERINARY pharmacology
N1 - Accession Number: 6871933; MARTINEZ, M 1; LANGSTON, C 2; MARTIN, T 3; CONNER, D 4; Source Information: Jun2002, Vol. 25 Issue 3, p201; Subject: VETERINARY drugs; Subject: VETERINARY pharmacology; Number of Pages: 20p; Document Type: Article
L3 - 10.1046/j.1365-2885.2002.00407.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=6871933&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106964589
T1 - Factors associated with smoking cessation among U.S. pregnant women.
AU - Yu SM
AU - Park CH
AU - Schwalberg RH
Y1 - 2002/06//
N1 - Accession Number: 106964589. Language: English. Entry Date: 20021004. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. NLM UID: 9715672.
KW - Smoking Cessation -- In Pregnancy
KW - Smoking -- In Pregnancy
KW - Health Behavior -- Evaluation -- In Pregnancy
KW - Surveys
KW - Cross Sectional Studies
KW - Female
KW - Pregnancy
KW - Adult
KW - Middle Age
KW - Interviews
KW - United States
KW - Data Analysis Software
KW - Logistic Regression
KW - Odds Ratio
KW - Confidence Intervals
KW - P-Value
KW - Descriptive Statistics
KW - Hispanics
KW - Race Factors
KW - Age Factors
KW - Educational Status
KW - Time Factors
KW - Human
SP - 89
EP - 97
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 6
IS - 2
CY - ,
PB - Springer Science & Business Media B.V.
AB - OBJECTIVES: This study examines smoking and smoking cessation behaviors among U.S. pregnant women and seeks to identify the sociodemographic correlates of smoking cessation in pregnancy. METHODS: The 1998 NHIS Pregnancy and Smoking supplement was analyzed, including 5288 U.S. women (weighted to represent 13,714,358 women) who gave birth to a liveborn infant in the past 5 years. Four categories of smoking behavior were analyzed: nonsmoking at last pregnancy, persistent smoking throughout pregnancy, attempting unsuccessfully to quit during pregnancy, and successfully quitting during pregnancy. Logistic regression was used to isolate risk factors for each of the smoking behaviors and to examine factors associated with attempted and successful cessation. RESULTS: The women most likely to attempt to quit smoking in pregnancy were Hispanic women (OR = 3.09) and women who have smoked for less than 10 years (OR = 2.75 for women aged 18-24.) In general, for the groups at highest risk of smoking at the start of pregnancy, the odds of being a persistent smoker were higher than the odds of being an unsuccessful quitter, which in turn were higher than the odds of quitting successfully. The factors associated with attempts to quit included Hispanic ethnicity, higher education, above-poverty income, and shorter duration of smoking, while the combined effect of age and smoking duration was the only one significantly associated with successful quitting. In every age group, longer smoking duration was associated with lower likelihood of attempting to quit as well as successful quitting. CONCLUSIONS: The factors most strongly associated with attempts to quit smoking were Hispanic ethnicity and the combined effect of age and smoking duration. Future smoking cessation and relapse prevention programs should be developed, taking into consideration the critical factors of age, ethnicity, income, geography, and addiction.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, 18-41, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 12092985.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106964589&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yu, Stella M.
AU - Park, Christina H.
AU - Schwalberg, Renee H.
T1 - Factors Associated with Smoking Cessation Among U.S. Pregnant Women.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2002/06//
VL - 6
IS - 2
M3 - Article
SP - 89
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives : This study examines smoking and smoking cessation behaviors among U.S. pregnant women and seeks to identify the sociodemographic correlates of smoking cessation in pregnancy. Methods : The 1998 NHIS Pregnancy and Smoking supplement was analyzed, including 5288 U.S. women (weighted to represent 13,714,358 women) who gave birth to a live-born infant in the past 5 years. Four categories of smoking behavior were analyzed: nonsmoking at last pregnancy, persistent smoking throughout pregnancy, attempting unsuccessfully to quit during pregnancy, and successfully quitting during pregnancy. Logistic regression was used to isolate risk factors for each of the smoking behaviors and to examine factors associated with attempted and successful cessation. Results : The women most likely to attempt to quit smoking in pregnancy were Hispanic women (OR = 3.09) and women who have smoked for less than 10 years (OR = 2.75 for women aged 18–24.) In general, for the groups at highest risk of smoking at the start of pregnancy, the odds of being a persistent smoker were higher than the odds of being an unsuccessful quitter, which in turn were higher than the odds of quitting successfully. The factors associated with attempts to quit included Hispanic ethnicity, higher education, above-poverty income, and shorter duration of smoking, while the combined effect of age and smoking duration was the only one significantly associated with successful quitting. In every age group, longer smoking duration was associated with lower likelihood of attempting to quit as well as successful quitting. Conclusions : The factors most strongly associated with attempts to quit smoking were Hispanic ethnicity and the combined effect of age and smoking duration. Future smoking cessation and relapse prevention programs should be developed, taking into consideration the critical factors of age, ethnicity, income, geography, and addiction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING cessation
KW - PREGNANCY
KW - ETHNICITY
KW - HEALTH education
KW - MATERNAL age
KW - education
KW - ethnicity
KW - maternal age
KW - pregnancy
KW - smoking cessation
N1 - Accession Number: 11307896; Yu, Stella M. 1,2; Email Address: syu@hrsa.gov; Park, Christina H. 3; Schwalberg, Renee H. 3; Source Information: Jun2002, Vol. 6 Issue 2, p89; Subject: SMOKING cessation; Subject: PREGNANCY; Subject: ETHNICITY; Subject: HEALTH education; Subject: MATERNAL age; Author-Supplied Keyword: education; Author-Supplied Keyword: ethnicity; Author-Supplied Keyword: maternal age; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: smoking cessation; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106940589
T1 - Device safety. Don't answer that cell phone!
AU - Marders J
AU - Witters D
Y1 - 2002/06//
N1 - Accession Number: 106940589. Language: English. Entry Date: 20020719. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Wireless Communications
KW - Equipment Safety
KW - Electromagnetic Fields -- Adverse Effects
KW - Equipment Failure
SP - 87
EP - 87
JO - Nursing
JF - Nursing
JA - NURSING
VL - 32
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Food and Drug Administration, Rockville, Md
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106940589&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106942351
T1 - Cancer survivorship research among ethnic minority and medically underserved groups.
AU - Aziz NM
AU - Rowland JH
Y1 - 2002/06//
N1 - Accession Number: 106942351. Language: English. Entry Date: 20050817. Revision Date: 20150819. Publication Type: Journal Article; research; systematic review. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 7809033.
KW - Cancer Survivors
KW - Minority Groups
KW - Medically Underserved
KW - Race Factors
KW - Quality of Life
KW - Quality of Health Care
KW - Research
KW - Outcomes (Health Care)
KW - Support, Psychosocial
KW - Male
KW - Female
KW - Human
SP - 789
EP - 801
JO - Oncology Nursing Forum
JF - Oncology Nursing Forum
JA - ONCOL NURS FORUM
VL - 29
IS - 5
CY - Pittsburgh, Pennsylvania
PB - Oncology Nursing Society
AB - PURPOSE/OBJECTIVES: To review the current state of knowledge about the impact of cancer on ethnoculturally diverse and medically underserved survivors. DATA SOURCES: MEDLINE, CancerLit, and Psychlit searches from 1966-present were conducted to locate articles about survivorship outcomes among minority and underserved populations. DATA SYNTHESIS: 65 articles were identified and grouped into one of four content areas: physiologic; psychosocial; health services, patterns of care, and quality of care; and health-promoting behaviors and lifestyles. CONCLUSIONS: Despite limited information, researchers found a consistent theme: the need to recognize and address the socioeconomic and cultural variables that affect adaptation to and survival from cancer among diverse groups of survivors. IMPLICATIONS FOR NURSING: The researchers found specific variations in risk for, response to, and recovery from cancer that provide direction for changes in nursing practice that may reduce the burden of cancer in these often vulnerable populations.
SN - 0190-535X
AD - Program Director, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD
U2 - PMID: 12058154.
DO - 10.1188/02.ONF.789-801
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106942351&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taylor, Michael D.
AU - Roberts, Jenny R.
AU - Hubbs, Ann F.
AU - Reasor, Mark J.
AU - Antonini, James M.
T1 - Quantitative Image Analysis of Drug-Induced Lung Fibrosis Using Laser Scanning Confocal Microscopy.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/06//
VL - 67
IS - 2
M3 - Article
SP - 295
EP - 302
PB - Oxford University Press / USA
SN - 10966080
AB - Pulmonary fibrosis is a serious lung disorder that in certain cases may be difficult to quantify. It was our objective to evaluate the use of laser scanning confocal microscopy (LSCM) in quantifying fibrosis after exposure to amiodarone (AD) and bleomycin (BLM), two commonly used therapeutic drugs known to cause debilitating lung fibrosis in humans. Male F344 rats were intratracheally dosed with AD (6.25 mg/kg on days 0 and 2), BLM (0.25 and 1.0 mg/kg on day 0), or their respective vehicle controls. The right lung was assayed for hydroxyproline, a biochemical measure of collagen, at day 21 for the BLM groups and day 28 for the AD groups. The left lung was fixed, sectioned into blocks, dehydrated, stained with Lucifer yellow (LY, 0.1 mg/ml), and embedded in Spurr resin. The area of lung tissue stained by LY was quantified by LSCM. A fibrotic response in the AD and BLM groups was confirmed by histopathological assessment and a significant increase (p < 0.05) in total right lung hydroxyproline above control values. The area of connective tissue stained by LY of the two drug-treated groups appeared as bright linear bands in the alveolar septae and was significantly increased (p < 0.05) as measured by image analysis when compared with their respective controls. LSCM, with its advanced image analysis system, is an alternate method to quantify fibrotic lung disease. LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Pulmonary fibrosis
KW - Amiodarone
KW - Bleomycin
KW - Confocal microscopy
KW - amiodarone
KW - bleomycin
KW - fibrosis
KW - laser scanning confocal microscopy
KW - Lucifer yellow
KW - three-dimensional reconstruction
N1 - Accession Number: 44406327; Taylor, Michael D. 1,2; Roberts, Jenny R. 2; Hubbs, Ann F. 2; Reasor, Mark J. 1; Antonini, James M. 2; Email Address: jga6@cdc.gov; Affiliations: 1: Department of Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Issue Info: Jun2002, Vol. 67 Issue 2, p295; Thesaurus Term: Toxicology; Subject Term: Pulmonary fibrosis; Subject Term: Amiodarone; Subject Term: Bleomycin; Subject Term: Confocal microscopy; Author-Supplied Keyword: amiodarone; Author-Supplied Keyword: bleomycin; Author-Supplied Keyword: fibrosis; Author-Supplied Keyword: laser scanning confocal microscopy; Author-Supplied Keyword: Lucifer yellow; Author-Supplied Keyword: three-dimensional reconstruction; Number of Pages: 8p; Illustrations: 4 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-08338-008
AN - 2002-08338-008
AU - Clancy, Carolyn M.
AU - Lawrence, William
T1 - Is outcomes research on cancer ready for prime time?
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2002/06//
VL - 40
IS - Suppl6
SP - III-92
EP - III-100
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Clancy, Carolyn M., Ctr for Outcomes & Effectiveness Research, Agency for Healthcare Research & Quality, 6010 Executive Boulevard, Rockville, MD, US, 20852
N1 - Accession Number: 2002-08338-008. Partial author list: First Author & Affiliation: Clancy, Carolyn M.; Agency for Healthcare Research & Quality, Ctr for Outcomes & Effectiveness Research, Rockville, MD, US. Release Date: 20030602. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health Care Services; Neoplasms; Treatment Outcomes. Classification: Cancer (3293). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Jun, 2002.
AB - Provides a brief overview of lessons learned from the first decade of outcomes research sponsored by the Agency for Healthcare Research and Quality that will inform suggested directions for future directions for cancer outcomes research. Topics discussed include the following: challenging clinical dogma, improved measures of outcome, new approaches for establishing research priorities, uptake of research findings, critical knowledge gaps, need for continued methodologic advances, implications of lessons learned for cancer outcomes research, cancer care should be patient centered, hypothesis generation and refinement, improved practice and outcomes, case management interventions, substrate for quality measures, and future challenges and opportunities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cancer outcomes research
KW - healthcare research
KW - quality
KW - 2002
KW - Experimentation
KW - Health Care Services
KW - Neoplasms
KW - Treatment Outcomes
KW - 2002
DO - 10.1097/00005650-200206001-00014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-08338-008&site=ehost-live&scope=site
UR - cclancy@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106979059
T1 - Reducing childhood pedestrian injuries.
AU - Schieber RA
AU - Vegega ME
Y1 - 2002/06/02/Jun2002 Supplement 1
N1 - Accession Number: 106979059. Language: English. Entry Date: 20021115. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Supplement Title: Jun2002 Supplement 1. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Wounds and Injuries -- Prevention and Control -- In Infancy and Childhood
KW - Accidents, Traffic -- Prevention and Control -- In Infancy and Childhood
KW - Child Safety
KW - Congresses and Conferences
KW - Child
SP - i1
EP - 10
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 8
PB - BMJ Publishing Group
SN - 1353-8047
AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Injury Prevention and Control
U2 - PMID: 12118694.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106979059&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Barger, Mark
AU - Robinson, Victor A.
AU - Leonard, Stephen S.
AU - Landsittel, Douglas
AU - Castranova, Vincent
T1 - Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat
JO - Toxicology
JF - Toxicology
Y1 - 2002/06/14/
VL - 175
IS - 1-3
M3 - Article
SP - 63
SN - 0300483X
AB - Most previous studies of silica toxicity have used relatively high exposure doses of silica. In this study, male rats received by intratracheal instillation either vehicle, aged or freshly fractured silica at a dose of either 5 μg/rat once a week for 12 weeks (total dose=60 μg) or 20 μg/rat once a week for 12 weeks (total dose=240 μg). One week after the last exposure, bronchoalveolar lavage (BAL) was conducted and markers of pulmonary inflammation, alveolar macrophage (AM) activation and pulmonary damage were examined. For rats exposed to a total of 60 μg silica, both aged and freshly fractured silica increased polymorphonuclear leukocytes (PMN) yield and AM activation above control to a similar degree, but no evidence of pulmonary damage, as measured by BAL fluid lactate dehydrogenase activity or albumin concentration, was detected. For rats exposed to 240 μg silica, aged or freshly fractured silica increased PMN yield and AM activation above control. However, zymosan-stimulated and l-NAME sensitive AM chemiluminescence was greater for rats exposed to freshly fractured silica compared to aged silica. Exposure to 240 μg aged or freshly fractured silica also resulted in pulmonary damage, but the extent of this damage did not differ between the two types of silica. The results suggest that exposure of rats to silica levels far lower than those previously examined can cause pulmonary inflammation. In addition, exposure to freshly fractured silica causes greater generation of reactive oxygen species from AM, measured as AM chemiluminescence, in comparison to aged silica, but there is an apparent threshold below which this difference does not occur. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silica
KW - Chemiluminescence
KW - Inflammation
N1 - Accession Number: 7817315; Porter, Dale W.; Email Address: dporter@cdc.gov; Barger, Mark 1; Robinson, Victor A. 1; Leonard, Stephen S. 1; Landsittel, Douglas 1; Castranova, Vincent 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505, USA; Issue Info: Jun2002, Vol. 175 Issue 1-3, p63; Subject Term: Silica; Subject Term: Chemiluminescence; Author-Supplied Keyword: Inflammation; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 9p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=7817315&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106538791
T1 - 2001 anthrax crisis in Washington, D.C.: clinic for persons exposed to contaminated mail.
AU - Haffer AST
AU - Rogers JR
AU - Montello MJ
AU - Frank EC
AU - Ostroff C
Y1 - 2002/06/15/
N1 - Accession Number: 106538791. Language: English. Entry Date: 20081219. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Anthrax -- Diagnosis -- District of Columbia
KW - Anthrax -- Prevention and Control -- District of Columbia
KW - Antibiotic Prophylaxis -- District of Columbia
KW - Biological Warfare -- District of Columbia
KW - Mail -- District of Columbia
KW - Disaster Planning -- District of Columbia
KW - Ambulatory Care -- District of Columbia
KW - District of Columbia
KW - Multidisciplinary Care Team
KW - Anthrax -- Symptoms
KW - Patient Education
KW - Anthrax -- Drug Therapy
KW - Hospitals
SP - 1189
EP - 1192
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 59
IS - 12
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - An anthrax prophylaxis clinic is described. In October 2001, four workers from the U.S. Postal Service's Brentwood facility in Washington, D.C., were hospitalized with inhalational anthrax; many others may have been exposed to anthrax spores. U.S. Public Health Service (USPHS) teams were deployed to establish an anthrax prophylaxis clinic that would provide education and medication to workers and people who visited the mail facility. The temporary clinic was set up at D.C. General Hospital and was staffed primarily by health care professionals from USPHS. The protocol at the clinic involved three major phases. Phase 1 consisted of gathering information from the patient and distributing educational materials. Phase 2 involved presentations by a physician and a pharmacist concerning anthrax, followed by a question-and-answer session. In phase 3, a pharmacist selected the most appropriate prophylactic agent, dispensed the medication, counseled the patient, and referred patients with flu-like symptoms or skin lesions to a physician. Two floor plans were used to maximize the number of patients seen per hour without jeopardizing patient care. The clinic operated 14 hours a day for 14 days. The 136-member health care team included 52 pharmacists, and medication was dispensed to more than 18,000 patients. The clinic may serve as a model for pharmacists and other professionals in designing and implementing disaster plans. A multidisciplinary team established and operated a clinic to treat persons who may have been exposed to anthrax through contaminated mail.
SN - 1079-2082
AD - Division of Drug Marketing, Advertising, and Communications, HFD-042, Food and Drug Administration, 5600 Fishers Lane, Room 17B-17, Rockville, MD 20852; haffera@cder.fda.gov
U2 - PMID: 12073860.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106538791&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106538793
T1 - 2001 anthrax crisis in Washington, D.C.: pharmacists' role in screening patients and selecting prophylaxis.
AU - Montello MJ
AU - Ostroff C
AU - Frank EC
AU - Haffer AST
AU - Rogres JR
Y1 - 2002/06/15/
N1 - Accession Number: 106538793. Language: English. Entry Date: 20081219. Revision Date: 20150711. Publication Type: Journal Article; forms. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Biological Warfare -- District of Columbia
KW - Anthrax -- District of Columbia
KW - Mail -- District of Columbia
KW - Antibiotic Prophylaxis -- District of Columbia
KW - Patient Selection -- Methods -- District of Columbia
KW - Decision Making, Clinical -- Methods -- District of Columbia
KW - Pharmacists -- District of Columbia
KW - Professional Role -- District of Columbia
KW - District of Columbia
KW - Algorithms
KW - Ambulatory Care
KW - Anthrax -- Drug Therapy
KW - Documentation
KW - Drug Hypersensitivity
KW - Pregnancy
KW - Lactation
KW - Female
SP - 1193
EP - 1199
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 59
IS - 12
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - Pharmacists' development and use of a worksheet facilitating their rapid selection of patient-appropriate prophylactic antimicrobials in an anthrax clinic is described. A clinic housed at D.C. General Hospital, in Washington, D.C., treated most of the people--many of them postal workers--who may have been exposed to anthrax in that city during the 2001 anthrax crisis. A form was needed to assist pharmacists in the rapid selection of prophylactic antimicrobials and in patient education and counseling. A team of pharmacists collaborated on the development of a form tailored to the clinical and logistical needs of the operation. The questions on the form were based largely on the two antianthrax agents most likely to be used, ciprofloxacin and doxycycline, and were designed to identify the circumstances that would most frequently require a medication change or a modification of patient education. Yes-or-no check boxes allowed pertinent data to be captured most efficiently. A positive response to any question triggered a personal interview and assessment by a pharmacist. A treatment algorithm was also developed to ensure consistent pharmacist selection of agents in the face of potentially changing policies and staff. The worksheet questions sought to establish treatment objectives, document allergies and concomitant therapies, and identify patients who were pregnant or lactating. Pharmacists developed a patient-screening worksheet that helped determine their choice of treatment for people who may have been exposed to anthrax in Washington, D.C., during the 2001 anthrax crisis.
SN - 1079-2082
AD - Chief Professional Officer-Pharmacy, PHS-1 Disaster Medical Assistance Team, U.S. Public Health Service, 6130 Executive Boulevard, Executive Plaza North, Room 6118, Rockville, MD 20852; montellom@ctep.nci.nih.gov
U2 - PMID: 12073861.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106985284
T1 - Accuracy and precision of two in-shoe pressure measurement systems.
AU - Hsiao H
AU - Guan J
AU - Weatherly M
Y1 - 2002/06/20/2002 Jun 20
N1 - Accession Number: 106985284. Language: English. Entry Date: 20021206. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Equipment Reliability
KW - Pressure -- Evaluation
KW - Shoes
KW - Biophysical Instruments
KW - Equipment Design
KW - Reliability and Validity
KW - Descriptive Statistics
KW - Calibration
KW - Time Factors
KW - Stress, Mechanical
KW - Analysis of Variance
KW - Confidence Intervals
KW - Human
SP - 537
EP - 555
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 45
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The recent rapid adoption of insole pressure measurement systems for clinical and ergonomic evaluations of human gait has necessitated a comprehensive understanding of the accuracy and precision of such systems. Five bench experiments were performed to examine the Pedar and F-Scan in-shoe pressure measurement systems. The insoles examined were the Pedar Y-sized right insole and the F-scan insole trimmed to the size and shape of a Pedar Y-sized insole. Data were sampled at 50 Hz at different levels of applied pressure, calibration procedure, duration of pressure application, insole age of use and experiment day or week. The system accuracy was determined by the per cent error of measurement, the system precision by the 95% tolerance interval of the per cent error. The results show that system accuracy and precision varied among levels of applied pressure, calibration procedure, duration of pressure application and insole age of use. The Pedar system showed the greatest accuracy and precision when the insole was new and measurements were taken (1) after a system calibration as specified by the manufacturer, (2) in the 50 - 500 kPa pressure range and (3) within a few seconds after pressure was applied. Under this condition, the measurement error was in the range -0.6 to 2.7%, and the magnitude (upper bound minus lower bound) of the 95% tolerance intervals was from 13.5 to 18.7%. Measuring less than 35 kPa with the Pedar system is not recommended. To ensure the accuracy and precision of the F-Scan system, users are recommended to estimate the range of the applied pressure and then choose a similar pressure level for calibration. Under this condition, the measurement error was in the range 1.3 - 5.8% and the magnitude (upper bound minus lower bound) of the 95% tolerance intervals was estimated to be in the range 1.1 - 14.8%. When the calibration pressure was outside this range of applied pressure, the per cent errors were considerably higher, ranging from -26.3 to 33.9%.
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505; hhsiao@cdc.gov
U2 - PMID: 12167198.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zamorano, P.
AU - Taboga, O.
AU - Domınguez, M.
AU - Romera, A.
AU - Puntel, M.
AU - Tami, C.
AU - Mongini, C.
AU - Waldner, C.
AU - Palma, E.
AU - Sadir, A.
T1 - BHV-1 DNA vaccination: effect of the adjuvant RN-205 on the modulation of the immune response in mice
JO - Vaccine
JF - Vaccine
Y1 - 2002/06/21/
VL - 20
IS - 21/22
M3 - Article
SP - 2656
SN - 0264410X
AB - It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccharide from gram-negative bacteria) as an adjuvant and analyzed the humoral and cellular specific immune responses elicited by DNA vaccines based on the bovine herpesvirus-1 (BHV-1) glycoprotein D (gD). The comparison of the antibody response induced in mice by a mixture of the three different versions of DNA gD (membrane-anchored, secreted and cytosolic) formulated with or without RN-205 showed that the immunomodulator did not affect the total specific humoral response. The cellular immune response induced in mice immunized with vaccines plus RN-205 was higher than that obtained in mice vaccinated without RN-205, not only in the indexes of proliferation tests but in the number of IL-4 and γIFN secreting cells. When total spleen cells were marked with specific monoclonal antibodies against surface markers, a significant increase in the macrophage population of all the groups receiving RN-205 was observed. CD8 and CD4 positive cells were also increased but to a lesser extent. Our results indicate that the incorporation of RN-205 into DNA vaccines induces an increase of the cellular specific immune response in mice. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - DNA vaccines
KW - Adjuvant
KW - Glycoprotein D
N1 - Accession Number: 7811941; Zamorano, P. 1,2; Email Address: pzamorano@cicv.inta.gov.ar; Taboga, O. 1; Domınguez, M. 1; Romera, A. 1; Puntel, M. 1; Tami, C. 1,3; Mongini, C. 4; Waldner, C. 4; Palma, E. 1,2; Sadir, A. 1,2; Affiliations: 1: Centro de Investigación en Ciencias Veterinarias y Agronómicas, INTA, CC25, (1712) Castelar, Serrano 669, Buenos Aires, Argentina; 2: CONICET, Bethesda, MD 20852, USA; 3: Center for Biological Evaluation and Research, Food and Drug Administration, Buenos Aires, Argentina; 4: Centro de Estudios Farmacológicos y Botánicos (CEFYBO, CONICET), Rivaoavia 1917, Buenos Aires, Argentina; Issue Info: Jun2002, Vol. 20 Issue 21/22, p2656; Thesaurus Term: Immune response; Subject Term: DNA vaccines; Author-Supplied Keyword: Adjuvant; Author-Supplied Keyword: Glycoprotein D; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - McGarrity, Lynda J.
AU - Morris, Suzanne M.
AU - Heflich, Robert H.
T1 - Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2002/06/27/
VL - 518
IS - 1
M3 - Article
SP - 55
SN - 13835718
AB - A novel approach was developed for rapidly estimating the frequency of specific mutations in genetically engineered Chinese hamster ovary (CHO) cells. We designed double-transgenic CHO cell lines that contain a transgene consisting of the sequence coding for green fluorescent protein under the control of a tetracycline (Tet) responsive promoter and a second transgene coding for the constitutively expressed Tet repressor. Cultures of these CHO cells were treated with γ-radiation, N-methyl-N-nitrosourea or methyl methanesulfonate, and the fluorescence of individual cells from both control and treated cultures was measured by flow cytometry. The treatments increased the number of highly fluorescent cells, those with presumed mutations in the Tet-repressor gene. Mutant cells from γ-radiation-exposed cultures were isolated by fluorescence-activated cell sorting, cultured, and individual clones expanded. A PCR-based analysis indicated that the highly fluorescent expanded cells had lost the transgene coding for the Tet repressor, suggesting that the system mainly detects large genetic alterations. A similar approach may be useful for making high-throughput in vivo models for mutation detection. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Green fluorescent protein
KW - Transgenic mice
KW - Cell lines
KW - γ
KW - -Radiation
KW - Fluorescence activated cell sorting
KW - Green fluorescent protein (GFP)
KW - Tetracycline (Tet) repressor
N1 - Accession Number: 7824290; Dobrovolsky, Vasily N.; Email Address: vdobrovolsky@nctr.fda.gov; McGarrity, Lynda J. 1; Morris, Suzanne M. 1; Heflich, Robert H. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-120, 72079 Jefferson, AR, USA; Issue Info: Jun2002, Vol. 518 Issue 1, p55; Thesaurus Term: Mutation (Biology); Subject Term: Green fluorescent protein; Subject Term: Transgenic mice; Subject Term: Cell lines; Author-Supplied Keyword: γ; Author-Supplied Keyword: -Radiation; Author-Supplied Keyword: Fluorescence activated cell sorting; Author-Supplied Keyword: Green fluorescent protein (GFP); Author-Supplied Keyword: Tetracycline (Tet) repressor; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106949843
T1 - Correspondence from abroad. A visit with the revered Dukuns of Indonesia: a nurse with an interest in alternative medicine meets a family of traditional healers.
AU - Gaines P
Y1 - 2002/07//
N1 - Accession Number: 106949843. Language: English. Entry Date: 20020816. Revision Date: 20150711. Publication Type: Journal Article; anecdote; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Medicine, Oriental Traditional -- Indonesia
KW - Indonesia
SP - 69
EP - 75
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 102
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Infection Control Officer and Employee Health Nurse, Indian Health Service, Elko, NV
U2 - PMID: 12394062.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Berg, AO;
AU - US Preventive Serv;
AU - Allan, JD;
AU - Frame, PS;
AU - Woolf, SH;
AU - et al;
T1 - Screening for depression: Recommendations and rationale
CT - Screening for depression: Recommendations and rationale
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 2002/07/01/
VL - 102
IS - Jul
SP - 77
EP - 61
SN - 0002936X
AD - Chair US Prevent Serv Task Force, Agcy Healthcare Res & Qual, 6010 Execut Blvd,Suite 300, Rockville, MD 20852, USA datkins@ahrq.gov
N1 - Accession Number: 39-15673; Language: English; References: 13; Journal Coden: AJNUAK; Section Heading: Pharmacology; Sociology, Economics and Ethics
N2 - This article presents the current guidelines set out by the U.S. Preventive Services Task Force with respect to screening for depression, and the scientific evidence supporting these recommendations.
KW - Depression--overview;
KW - Diagnosis--depression;
KW - Protocols--depression;
KW - Epidemiology--depression;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 106953207
T1 - Health effects associated with medical glove use.
AU - Dillard SF
AU - Hefflin B
AU - Kaczmarek RG
AU - Petsonk EL
AU - Gross TP
Y1 - 2002/07//
N1 - Accession Number: 106953207. Language: English. Entry Date: 20020830. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 0372403.
KW - Latex Hypersensitivity
KW - Gloves -- Adverse Effects
KW - United States Food and Drug Administration
KW - Product Surveillance
KW - Voluntary Reporting
KW - Mandatory Reporting
KW - Retrospective Design
KW - Databases
KW - Data Analysis Software
KW - Chi Square Test
KW - Health Personnel
KW - Male
KW - Female
KW - Human
SP - 88
EP - 96
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 76
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Adverse reactions to medical gloves represent an important public health issue. Accordingly, there is increasing interest in understanding the information reported to the US Food and Drug Administration (FDA) describing health effects associated with the use of medical gloves. This article provides a retrospective analysis and summary of health effects associated with medical glove use reported to the FDA. The FDA's medical device adverse event databases were searched via computer using keywords to identify reports of reactions associated with any type of medical glove. Demographic and clinical information abstracted from these reports was used to perform frequency and trend analyses. The reported medical glove-related events, including the noted trends in reporting, suggest the need for further study and continued monitoring of such reports.
SN - 0001-2092
AD - Senior Scientist, US Food and Drug Administration, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Rockville, Md
U2 - PMID: 12134403.
DO - 10.1016/S0001-2092(06)61098-3
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Khan, A. A.
AU - Nawaz, M. S.
AU - Khan, S. A.
AU - Steele, R.
T1 - Detection and characterization of erythromycin-resistant methylase genes in Gram-positive bacteria isolated from poultry litter.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2002/07//
VL - 59
IS - 2/3
M3 - Article
SP - 377
EP - 381
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - The epidemiology of four erythromycin-resistant methylase (erm) genes, ermA, ermB, ermC and msrA, was determined in erythromycin-resistant staphylococci, enterococci and streptococci isolated from poultry litter. All isolates were resistant to multiple antibiotics. Southern hybridization indicated that 4 of the 20 staphylococci contained the ermC gene on plasmids: on a 2.2 kb plasmid in Staphylococcus hominis and S. sciuri, on a 6.0 kb plasmid in S. xylosus, and on a 7.0 kb plasmid in S. lentus. In 16 of the 20 staphylococci, the ermA gene was harbored exclusively on the chromosome, as a double chromosomal insert on 8.0 and 6.2 kb EcoRI fragments. None of the staphylococci harbored the msrA gene. Dot-blot analysis indicated that all enterococci and streptococci hybridized with a biotinylated ermB gene probe. Southern hybridization indicated that only 2 of the 19 erythromycin-resistant enterococci contained the ermB gene on plasmids. The gene was localized on 4.0 kb and 5.9 kb plasmids, respectively, in two Enterococcus faecium isolates. Results from our studies indicate that the patterns of occurrence of erm genes, the sizes of the plasmids and the copy numbers of the inserts were different from the existing information on the presence of erm genes in clinical strains of Staphylococcus spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Erythromycin
KW - Methyltransferases
KW - Genes
KW - Staphylococcus
KW - Enterococcus
KW - Streptococcus
KW - Plasmids
KW - Chromosomes
N1 - Accession Number: 15681189; Khan, A. A. 1; Nawaz, M. S. 1; Email Address: mnawaz@nctr.fda.gov; Khan, S. A. 1; Steele, R. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Jul2002, Vol. 59 Issue 2/3, p377; Subject Term: Erythromycin; Subject Term: Methyltransferases; Subject Term: Genes; Subject Term: Staphylococcus; Subject Term: Enterococcus; Subject Term: Streptococcus; Subject Term: Plasmids; Subject Term: Chromosomes; Number of Pages: 5p; Illustrations: 4 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1007/s00253-002-1013-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Armstrong, Tina N.
AU - Reimschuessel, Renate
AU - Bradley, Brian P.
T1 - DNA damage, histologial changes and DNA repair in larval Japanese medaka (Oryzias latipes) exposed to ultraviolet-B radiation
JO - Aquatic Toxicology
JF - Aquatic Toxicology
Y1 - 2002/07//
VL - 58
IS - 1/2
M3 - Article
SP - 1
SN - 0166445X
AB - Cyclobutane dimer formation, photorepair capability and histological damage were compared among four differently pigmented strains of larval Japanese medaka (Oryzias latipes) to determine whether pigmentation modifies the level of UV-B radiation (290–320 nm) inducible damage in these fish. One-day post-hatch medaka were exposed to one of several UV-B fluence rates with or without photoreactivating light for 5 days for 7 h per day. Their DNA was extracted for analysis by ELISA for cyclobutane pyrimidine dimers or the larvae were processed for histological examination. At the higher UV-B fluence rates tested, wild-type melanophore-containing medaka formed significantly more dimers than at least one of the other strains tested. Wild-type medaka also showed significantly less photorepair capability than the white melanophore-lacking medaka. The wild-type larvae had significantly more necrosis than the orange–red melanophore-lacking larvae at the lower UV-B fluence rate tested and at the higher fluence rate used, the wild-type medaka also exhibited significantly more necrosis than the white melanophore-lacking larvae. Of the 19 medaka observed with cellular hyperplasia, six were wild-type. These six individual larvae showed the greatest degree of cellular hyperplasia. Cellular hyperplasia appeared to be greatest at the lowest UV-B fluence rate used. The presence of melanophores in the wild-type medaka may have contributed to an increased level of tissue damage in this strain when compared to the other strains. [Copyright &y& Elsevier]
AB - Copyright of Aquatic Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Larvae
KW - DNA
KW - Cyclobutadiene
KW - Hyperplasia
KW - Japan
KW - Cyclobutane pyrimidine dimer
KW - Fish
KW - Necrosis
KW - Photoreactivation
KW - UV-B
N1 - Accession Number: 7792834; Armstrong, Tina N. 1; Email Address: ta@bbl-inc.com; Reimschuessel, Renate 2; Email Address: rreimsch@cvm.fda.gov; Bradley, Brian P. 3; Email Address: bbradley@umbc.edu; Affiliations: 1: BBL Sciences, 326 First Street, Suite 200, Annapolis, MD 21403-2678, USA; 2: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA; 3: Department of Biological Sciences, University of Maryland (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA; Issue Info: Jul2002, Vol. 58 Issue 1/2, p1; Thesaurus Term: Larvae; Subject Term: DNA; Subject Term: Cyclobutadiene; Subject Term: Hyperplasia; Subject: Japan; Author-Supplied Keyword: Cyclobutane pyrimidine dimer; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Necrosis; Author-Supplied Keyword: Photoreactivation; Author-Supplied Keyword: UV-B; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hur, Hor-Gil
AU - Beger, Richard D.
AU - Heinze, Thomas M.
AU - Lay Jr., Jackson O.
AU - Freeman, James P.
AU - Dore, Joel
AU - Rafii, Fatemeh
T1 - Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2002/07//
VL - 178
IS - 1
M3 - Article
SP - 8
EP - 12
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - Colonic bacteria were screened for bacteria involved in the conversion of phytoestrogens. A gram-positive anaerobic bacterium, strain HGH 136, capable of conversion of the isoflavonoid daidzein, was isolated and identified as a Clostridium sp. The bacterium cleaved the C-ring of daidzein to produce O-demethylangolensin (O-Dma). This compound was identified by comparison of the HPLC retention time and UV spectrum of the metabolite with chemically synthesized O-Dma. The identity of the metabolite was confirmed by liquid chromatography-mass spectrometry and NMR using synthetic O-Dma as a standard. The bacterium incubated with synthetic dihydrodaidzein also produced O-Dma. After 3 days of incubation, 28% of added daidzein and 12% of added dihydrodaidzein were converted to O-Dma. This is the first study in which an anaerobic bacterium involved in the ring cleavage of daidzein to produce O-Dma has been identified. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anaerobic bacteria
KW - Plant hormones
KW - Phytoestrogens
KW - High performance liquid chromatography
KW - Estrogen
KW - High pressure (Science)
KW - C-ring fission
KW - Daidzein
KW - Isoflavonoids
N1 - Accession Number: 15731527; Hur, Hor-Gil 1,2; Beger, Richard D. 3; Heinze, Thomas M. 3; Lay Jr., Jackson O. 3; Freeman, James P. 3; Dore, Joel 4; Rafii, Fatemeh 2; Email Address: Frafii@nctr.fda.gov; Affiliations: 1: School of Agricultural Biotechnology, Seoul National University, Suwon, Korea; 2: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA; 3: Division of Chemistry, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA; 4: INRA, Jouy-en-Josas, France; Issue Info: Jul2002, Vol. 178 Issue 1, p8; Thesaurus Term: Anaerobic bacteria; Thesaurus Term: Plant hormones; Subject Term: Phytoestrogens; Subject Term: High performance liquid chromatography; Subject Term: Estrogen; Subject Term: High pressure (Science); Author-Supplied Keyword: C-ring fission; Author-Supplied Keyword: Daidzein; Author-Supplied Keyword: Isoflavonoids; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/s00203-002-0414-6
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106707754
T1 - Shared border, shared challenges.
AU - Clancy CM
Y1 - 2002/07//2002 Jul
N1 - Accession Number: 106707754. Language: English. Entry Date: 20040227. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Ruelas E. Health care research and improvement. Health care quality improvement in Mexico: challenges, opportunities, and progress. (BAYLOR UNIV MED CENT PROC) 2002 Jul; 15 (3): 319-322. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9302033.
KW - Quality Improvement
KW - Quality of Health Care -- Mexico
KW - Government Agencies
KW - Mexico
KW - Private Sector
KW - Public Sector
SP - 322
EP - 323
JO - Baylor University Medical Center Proceedings
JF - Baylor University Medical Center Proceedings
JA - BAYLOR UNIV MED CENT PROC
VL - 15
IS - 3
CY - Dallas, Texas
PB - Baylor University Medical Center
SN - 0899-8280
AD - Acting Director, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 16333455.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106794684
T1 - A preoperative smoking intervention decreased postoperative complications in elective knee or hip replacement.
AU - Murray EW
Y1 - 2002/07//
N1 - Accession Number: 106794684. Language: English. Entry Date: 20030103. Revision Date: 20150820. Publication Type: Journal Article; abstract; commentary; tables/charts. Original Study: Møller AM, Villebro N, Pedersen T, Tønnesen H. Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial. (LANCET) 1/12/2002; 359 (9301): 114-117. Journal Subset: Core Nursing; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9815947.
KW - Postoperative Complications -- Prevention and Control
KW - Smoking -- Complications
KW - Smoking -- Prevention and Control
KW - Clinical Trials
KW - Arthroplasty, Replacement -- History
KW - Arthroplasty, Replacement, Knee
KW - Denmark
KW - Smoking Cessation
KW - Preoperative Period
SP - 84
EP - 84
JO - Evidence Based Nursing
JF - Evidence Based Nursing
JA - EVID BASED NURS
VL - 5
IS - 3
PB - BMJ Publishing Group
AB - QUESTION: Does a preoperative smoking intervention reduce postoperative morbidity and mortality in patients having elective knee or hip replacement?DesignRandomised (allocation concealed)*, blinded (outcome assessor), controlled trial with follow up to discharge.Setting3 university affiliated hospitals in Copenhagen, Denmark.Patients120 patients who were scheduled for primary elective hip or knee replacement and were daily smokers. Patients with a weekly alcohol intake > 35 units were excluded. 108 patients (90%) were included in the analysis (median age 65 y, 57% women).InterventionAt 6-8 weeks before surgery, 60 patients were allocated to the smoking intervention and were offered a weekly meeting with the project nurse. At the first meeting, a Fagerstom test was done to estimate the patient's nicotine dependence. Jest results and patient preference were used to devise a personalised nicotine substitution schedule. Patients were strongly encouraged to stop smoking, but had the option to reduce tobacco consumption by >/= 50%. Smoking status was monitored, and nicotine substitution products were provided free of charge. At subsequent meetings, tobacco consumption was recorded and patients were given advice about smoking cessation or reduction, benefits and side effects, and management of withdrawal symptoms and weight gain. 60 patients were allocated to usual care (little or no information or counselling on smoking).Main outcome measurePostoperative complications (death or postoperative morbidity requiring treatment within 4 wks after surgery).Main resultsAnalysis was by intention to treat. No patients died before discharge. Rates of any postoperative complication and of wound related complications were lower in the smoking intervention group than in the usual care group (table).ConclusionsA preoperative smoking intervention was more effective than usual care for reducing rates of any postoperative complication and wound related complications in patients having elective knee or hip replacement. No deaths occurred before discharge.*Information provided by author.
SN - 1367-6539
AD - Captain, US Public Health Service, Senior Health Policy Analyst, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 12123268.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106794684&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Al-Humadi, Nabil H.
AU - Siegel, Paul D.
AU - Lewis, Daniel M.
AU - Barger, Mark W.
AU - Ma, Jane Y. C.
AU - Weissman, David N.
AU - Ma, Joseph K. H.
T1 - THE EFFECT OF DIESEL EXHAUST PARTICLES (DEP) AND CARBON BLACK (CB) ON THIOL CHANGES IN PULMONARY OVALBUMIN ALLERGIC SENSITIZED BROWN NORWAY RATS.
JO - Experimental Lung Research
JF - Experimental Lung Research
Y1 - 2002/07//
VL - 28
IS - 5
M3 - Article
SP - 333
EP - 349
PB - Taylor & Francis Ltd
SN - 01902148
AB - Brown Norway rats were exposed by intratracheal instillation of saline, carbon black (CB), or diesel exhaust particles (DEP) (5 mg/kg) on day 1, followed by exposure to ovalbumin (OVA, 90 mg/m[sup 3] ) or saline for 30 minutes on days 1, 8, 15, and 29. Animals were sacrificed on day 30. The DEP, CB, or OVA exposure alone did not result in abnormal levels of inflammatory cells, lactate dehydrogenase (LDH), or total protein in the lavage fluid. In combined OVA-DEP or OVA-CB exposure, however, these markers were significantly increased. The adjuvant effect of CB and DEP on OVA sensitization was evidenced by the marked increases in serum OVA-specific IgG (5.6-fold) and IgE (3.5-4 fold) levels, and the increase in interleukin-4 (IL-4) mRNA levels in lung tissue. The OVA exposure markedly reduced glutathione (GSH) levels in both cell types. In combined DEP-OVA exposure, the level of GSH in lymphocytes was further decreased, indicating a possible interactive effect between DEP and OVA exposures. These results show that both DEP and CB augmented OVA-induced allergic sensitization, and that particle composition of DEP may not be a critical factor for the adjuvant effect. OVA exposure causes significant depletion of intracellular GSH in lymphocytes, which may play a key role in OVA-mediated immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Lung Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIESEL motor exhaust gas
KW - CARBON compounds
KW - ALLERGY
KW - GLUTATHIONE
KW - Diesel exhaust particles
KW - Immunoglobulin
KW - Interleukin-4
KW - OVALBUMIN
KW - THIOLS
N1 - Accession Number: 6885998; Al-Humadi, Nabil H. 1; Siegel, Paul D. 2; Lewis, Daniel M. 2; Barger, Mark W. 2; Ma, Jane Y. C. 2; Weissman, David N. 2; Ma, Joseph K. H. 3; Source Information: Jul2002, Vol. 28 Issue 5, p333; Subject: DIESEL motor exhaust gas; Subject: CARBON compounds; Subject: ALLERGY; Subject: GLUTATHIONE; Author-Supplied Keyword: Diesel exhaust particles; Author-Supplied Keyword: Immunoglobulin; Author-Supplied Keyword: Interleukin-4; Author-Supplied Keyword: OVALBUMIN; Author-Supplied Keyword: THIOLS; Number of Pages: 17p; Document Type: Article
L3 - 10.1080/01902140290091976
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Dean-Ross, Deborah
AU - Moody, Joanna
AU - Cerniglia, C.E.
T1 - Utilization of mixtures of polycyclic aromatic hydrocarbons by bacteria isolated from contaminated sediment
JO - FEMS Microbiology Ecology
JF - FEMS Microbiology Ecology
Y1 - 2002/07//
VL - 41
IS - 1
M3 - Article
SP - 1
SN - 01686496
AB - The ability of sediment bacteria to utilize polycyclic aromatic hydrocarbons (PAHs) when present as components of mixtures was investigated. One strain, identified as Mycobacterium flavescens, could utilize fluoranthene in the presence of pyrene, although utilization of pyrene was slower in the presence of fluoranthene than in its absence. The second strain, a Rhodococcus species, could utilize fluoranthene in the presence of anthracene, although the presence of fluoranthene slowed the rate of utilization of anthracene. Cometabolism of fluoranthene in these strains was confirmed by the isolation of metabolites of fluoranthene and by kinetic analysis of the rate of utilization of the growth substrate in the presence of fluoranthene. In both strains, metabolism of fluoranthene occurred on the fused ring of the fluoranthene molecule, producing 9-fluorenone-1-carboxylic acid. In the Rhodococcus sp., a second metabolite, a-(carboxymethylene)fluorene-1-carboxylic acid, was identified, indicating that this strain has the capacity to metabolize fluoranthene via ortho as well as meta cleavage. The presence of PAHs in a mixture produces interactive effects which can either increase or decrease the rate of utilization of individual PAHs, results which need to be taken into account when estimating rates of degradation in contaminated environments. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Ecology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteria
KW - Polycyclic aromatic hydrocarbons
KW - Biodegradation
KW - Anthracene
KW - Bioremediation
KW - Cometabolism
KW - Fluoranthene
KW - Mixture
KW - Phenanthrene
KW - Polycyclic aromatic hydrocarbon
KW - Pyrene
KW - Sediment
N1 - Accession Number: 7831224; Dean-Ross, Deborah 1; Email Address: ross@ipfw.edu; Moody, Joanna 2; Cerniglia, C.E. 2; Affiliations: 1: Department of Biology, Indiana University-Purdue University, Fort Wayne, IN 46805-1499, USA; 2: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Jul2002, Vol. 41 Issue 1, p1; Thesaurus Term: Bacteria; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Biodegradation; Author-Supplied Keyword: Anthracene; Author-Supplied Keyword: Bioremediation; Author-Supplied Keyword: Cometabolism; Author-Supplied Keyword: Fluoranthene; Author-Supplied Keyword: Mixture; Author-Supplied Keyword: Phenanthrene; Author-Supplied Keyword: Polycyclic aromatic hydrocarbon; Author-Supplied Keyword: Pyrene; Author-Supplied Keyword: Sediment; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106963817
T1 - From the Food and Drug Administration. Better health care with quality medical devices: FDA on the cutting edge of device technology.
AU - Rich S
Y1 - 2002/07//2002 Jul-Sep
N1 - Accession Number: 106963817. Language: English. Entry Date: 20021004. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 9506955.
KW - Technology, Medical -- Trends
KW - United States Food and Drug Administration
KW - Consumer Product Safety
SP - 89
EP - 90
JO - International Journal of Trauma Nursing
JF - International Journal of Trauma Nursing
JA - INT J TRAUMA NURS
VL - 8
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1075-4210
AD - Supervisory Nurse Consultant, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Product Evaluation Branch II, Food and Drug Adminstration, 1350 Piccard Dr, Rockville, MD 20850; ser@cdrh.fda.gov
U2 - PMID: 12094161.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822641
T1 - Advanced science education in the regulatory arena: the Center for Drug Evaluation and Research Experience at the Food and Drug Administration.
AU - Ajayi FO
AU - Wilcox DF
AU - Uhl K
AU - Quinn J
Y1 - 2002/07//
N1 - Accession Number: 105822641. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Biological Science Disciplines -- Education
KW - Biological Science Disciplines -- Legislation and Jurisprudence
KW - Education, Continuing -- Administration
KW - Research
KW - United States Food and Drug Administration -- Administration
KW - Drug Evaluation
KW - Models, Educational
KW - United States
SP - 711
EP - 717
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 7
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - A challenge faced by the Center for Drug Evaluation and Research (CDER) in effectively carrying out its mission requires it to integrate the disciplines of science, medicine, law, and public policy. One way to do that is by ensuring a highly trained multidisciplinary staff. The CDER has been able to meet this requirement by identifying the core competencies needed to accomplish its mission. The use of a competency-based training model in the planning, development, and delivery of its advanced scientific education program allows CDER staff to maintain current knowledge as well as prepare for future scientific education needs. The CDER educational model could be readily adapted to meet the educational needs of other organizations.
SN - 0091-2700
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
U2 - PMID: 12092738.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822642
T1 - Educational issues in clinical pharmacology: who are our audiences and what are their specialized needs? One specialized need: 'understanding the role of veterinary medicine in public health'.
AU - Lathers CM
Y1 - 2002/07//
N1 - Accession Number: 105822642. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Antiinfective Agents -- Therapeutic Use
KW - Drugs -- Therapeutic Use
KW - Pharmacy and Pharmacology -- Education
KW - Public Health
KW - Animals
KW - Antiinfective Agents -- Adverse Effects
KW - Ceftriaxone -- Therapeutic Use
KW - Drug Resistance, Microbial
KW - Drugs -- Adverse Effects
KW - Education, Pharmacy
KW - Forecasting
KW - Models, Educational
KW - Public Policy
KW - Risk Assessment -- Legislation and Jurisprudence
KW - Salmonella Infections -- Drug Therapy
KW - United States
KW - Zoonoses -- Drug Therapy
SP - 718
EP - 730
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 7
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - When considering educational issues and the need to update the curriculum for clinical pharmacologists for the new millennium, a number of questions must be raised. Who are our audiences? What are the specialized needs? This educational article identifies the audience, which includes those with diverse degrees such as MDs, PhDs, PharmDs, RNs, DVMs, and other non-MD prescribers working in academia, industry, clinical research organizations, and government in multifaceted disciplines requiring a knowledge base of physiology, pharmacology, biochemistry, anatomy, microbiology, pathology, medicine, and the drug development process of preclinical and clinical studies complete with protocols, pharmacokinetics, and statistics. One specialized current educational issue for clinical pharmacologists to understand is the impact of animal therapeutic and subtherapeutic use of antimicrobials on antibiotic use in human medicine.
SN - 0091-2700
AD - Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20855, USA.
U2 - PMID: 12092739.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Park, Jae Hyun
AU - Park, Seung Hee
AU - Kim, Hyung Soo
AU - Oh, Hye Young
T1 - A nonradioisotopic endpoint for measurement of lymph node cell proliferation in a murine allergic contact dermatitis model, using bromodeoxyuridine immunohistochemistry
JO - Journal of Pharmacological & Toxicological Methods
JF - Journal of Pharmacological & Toxicological Methods
Y1 - 2002/07//
VL - 48
IS - 1
M3 - Article
SP - 53
SN - 10568719
AB - Introduction: The murine local lymph node assay (LLNA) was developed as an alternative to guinea pig models for the assessment of the xenobiotic contact sensitization potential. However, it would be advantageous to have an alternative endpoint to the usual radioisotopic-dependent measures. In the present study, we investigated the development of a nonradioisotopic endpoint for LLNA using immunohistochemistry. Methods: Female Balb/c mice were treated by the topical application of strong sensitizers, 2,4-dinitrochlorobenzene (DNCB) and toluene diisocyanate (TDI), and a strong irritant, sodium lauryl sulfate (SLS), on the dorsum of both ears once daily for three consecutive days. The proliferation of cells in the auricular lymph node and ears was analyzed by means of the labeling index (LI) of bromodeoxyuridine (BrdU) incorporation into cells. Results: Skin reactions, consisting of increased ear thickness and the presence of inflammatory cell infiltrates, were observed in mice treated with DNCB and TDI. The cell number and the weight of the lymph nodes in the mice treated with the allergens, DNCB and TDI, were increased compared to vehicle control. We observed an increase in the areas of the B220+ cells in the lymph nodes of mice treated with allergens, as determined by immunohistochemistry. There was an increase in the percentage of B220+ cells in mice treated with DNCB and TDI compared to the vehicle control, but not in those treated with SLS. Because we observed an increase in the percentage of B cells in the allergen-treated group, we measured the stimulation index (SI) in the cortex and medulla (C+M) of the lymph node. The SI values of the C+M in the lymph nodes of the mice treated with DNCB and TDI were increased more than threefold compared with that of the control. However, the SI of the C+M in the lymph nodes of the mice exposed to 25% SLS was not significantly increased compared to the vehicle control, although the lymph node weight of the SLS group was significantly increased. Discussion: In Balb/c mice, BrdU immunohistochemistry showed its potential use for the identification and differentiation of chemicals with the capacity to induce irritation and sensitization. The results suggest that the measurement of the SI in the cortex and medulla of the lymph node using BrdU immunohistochemistry could provide a useful method to screen irritants and allergens. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmacological & Toxicological Methods is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Immunohistochemistry
KW - 2,4-dinitrochlorobenzene (DNCB)
KW - 4:1 acetone/olive oil (AOO)
KW - Allergen
KW - BrdU immunohistochemistry
KW - bromodeoxyuridine (BrdU)
KW - Cortex
KW - cortex and medulla (C+M)
KW - DNCB
KW - Irritant
KW - labeling index (LI)
KW - LLNA
KW - local lymph node assay (LLNA)
KW - Medulla
KW - Methods
KW - SLS
KW - sodium lauryl sulfate (SLS)
KW - stimulation index (SI)
KW - TDI
KW - toluene diisocyanate (TDI)
N1 - Accession Number: 9712740; Lee, Jong Kwon; Email Address: jkleest@kfda.go.kr; Park, Jae Hyun 1; Park, Seung Hee 1; Kim, Hyung Soo 1; Oh, Hye Young 1; Affiliations: 1: Division of Immunotoxicology, Department of Toxicology, Korea Food and Drug Administration, National Institute of Toxicology Research, Seoul 122-704, South Korea; Issue Info: Jul2002, Vol. 48 Issue 1, p53; Thesaurus Term: Allergens; Subject Term: Immunohistochemistry; Author-Supplied Keyword: 2,4-dinitrochlorobenzene (DNCB); Author-Supplied Keyword: 4:1 acetone/olive oil (AOO); Author-Supplied Keyword: Allergen; Author-Supplied Keyword: BrdU immunohistochemistry; Author-Supplied Keyword: bromodeoxyuridine (BrdU); Author-Supplied Keyword: Cortex; Author-Supplied Keyword: cortex and medulla (C+M); Author-Supplied Keyword: DNCB; Author-Supplied Keyword: Irritant; Author-Supplied Keyword: labeling index (LI); Author-Supplied Keyword: LLNA; Author-Supplied Keyword: local lymph node assay (LLNA); Author-Supplied Keyword: Medulla; Author-Supplied Keyword: Methods; Author-Supplied Keyword: SLS; Author-Supplied Keyword: sodium lauryl sulfate (SLS); Author-Supplied Keyword: stimulation index (SI); Author-Supplied Keyword: TDI; Author-Supplied Keyword: toluene diisocyanate (TDI); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S1056-8719(03)00021-2
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Junod, Suzanne White
T1 - Perspectives on the Pill: An Essay Review.
JO - Journal of the History of Medicine & Allied Sciences
JF - Journal of the History of Medicine & Allied Sciences
Y1 - 2002/07//
VL - 57
IS - 3
M3 - Book Review
SP - 333
EP - 339
SN - 00225045
AB - Reviews four books on the history of birth control in the United States. Donald T. Critchlow's 'Intended Consequences: Birth Control, Abortion, and the Federal Government in Modern America' (1999) discusses federal government policy on birth control and abortion before and after the pill, including racial and religious divisions. Andrea Tone's 'Devices and Desires: A History of Contraceptives in America' (2001) traces the consumer's views of birth control before and after the pill's release as a birth control device in 1960, including a history of contraceptives in America since the 1873 Comstock Act defined contraceptives as obscene. Elizabeth Siegel Watkins's 'On the Pill: A Social History of Oral Contraceptives, 1950-1970' (1998) concentrates on the safety of the pill. Lara V. Marks's 'Sexual Chemistry: A History of the Contraceptive Pill' (2001) documents the early development of the pill, detailing how the wild Mexican yam paved the way for the pill and the effect of the pill on women's life choices.
KW - NONFICTION
KW - WOMEN
KW - ORAL contraceptives
KW - BIRTH control
KW - LITERATURE reviews
KW - CRITCHLOW, Donald T., 1948-
KW - MARKS, Lara V.
KW - TONE, Andrea
KW - INTENDED Consequences: Birth Control, Abortion & the Federal Government in Modern America (Book)
KW - SEXUAL Chemistry: A History of the Contraceptive Pill (Book)
KW - DEVICES & Desires: A History of Contraceptives in America (Book)
N1 - Accession Number: 44549182; Junod, Suzanne White 1; Email Address: sjunod@ora.fda.gov; Affiliations: 1 : Historian for the U.S. Food and Drug Administration, FDA History Office, HFC-24, Room 13-51, Rockville; Source Info: Jul2002, Vol. 57 Issue 3, p333; Note: Note.; Historical Period: 1950 to 1999; Subject Term: NONFICTION; Subject Term: WOMEN; Subject Term: ORAL contraceptives; Subject Term: BIRTH control; Subject Term: LITERATURE reviews; Number of Pages: 7p; Document Type: Book Review
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Klinman, Dennis M.
AU - Takeshita, Fumihiko
AU - Gursel, Ihsan
AU - Leifer, Cynthia
AU - Ishii, Ken J.
AU - Verthelyi, Daniela
AU - Gursel, Mayda
T1 - CpG DNA: recognition by and activation of monocytes
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2002/07//
VL - 4
IS - 9
M3 - Article
SP - 897
SN - 12864579
AB - Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune response characterized by the activation of Ig- and cytokine-secreting cells. Synthetic oligonucleotides (ODNs) containing CpG motifs mimic this activity, triggering monocytes to proliferate, secrete and/or differentiate. Analysis of hundreds of novel ODNs led to the identification of two structurally distinct classes of CpG motif that differentially activate human monocytes. ODNs of the “K”-type interact with Toll-like receptor 9 and induce monocytes to proliferate and secrete IL-6. In contrast, “D”-type ODNs trigger monocytes to differentiate into mature dendritic cells. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Monocytes
KW - Activation
KW - CpG DNA
N1 - Accession Number: 7839864; Klinman, Dennis M.; Email Address: klinman@cber.fda.gov; Takeshita, Fumihiko 1; Gursel, Ihsan 1; Leifer, Cynthia 1; Ishii, Ken J. 1; Verthelyi, Daniela 1; Gursel, Mayda 1; Affiliations: 1: Retroviral Immunology Section, Center for Biologics Evaluation and Research, FDA, Bldg 29A Rm 3 D 10, Bethesda, MD 20892, USA; Issue Info: Jul2002, Vol. 4 Issue 9, p897; Thesaurus Term: Immune response; Subject Term: Monocytes; Author-Supplied Keyword: Activation; Author-Supplied Keyword: CpG DNA; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106977458
T1 - Of specialty interest: a review of research strategies for clinicians.
AU - Baker K
Y1 - 2002///2002 Summer
N1 - Accession Number: 106977458. Language: English. Entry Date: 20021115. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Granger BB. Research strategies for clinicians. (CRIT CARE NURS CLIN NORTH AM) 2001 Dec; 13 (4): 605-615. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9206573.
KW - Clinical Nursing Research
KW - Nursing Practice, Evidence-Based
KW - Research Question
KW - Data Collection
KW - Brainstorming
KW - Motivation
KW - Multidisciplinary Care Team
KW - Research Personnel
KW - Otorhinolaryngology and Head-Neck Nursing
KW - Research Methodology
SP - 23
EP - 24
JO - ORL-Head & Neck Nursing
JF - ORL-Head & Neck Nursing
JA - ORL HEAD NECK NURS
VL - 20
IS - 3
CY - New Smyrna Beach, Florida
PB - Society of Otorhinolaryngology & Head-Neck Nurses
AB - A simple, straightforward approach to clinical research may be a catalyst to stimulate research in the field of otorhinolaryngology (ORL) nursing. Sometimes the greatest difficulty lies in knowing how to get started. A brief, random questionnaire distributed at the 2001 Annual Congress of the Society of Otorhinolaryngology and Head-Neck Nurses revealed that many ORL nurses are not currently active in a research project but are intrigued by the concept. Barriers identified by survey participants included: knowing how to get started, no prior experience, no peer support, the need for a research mentor, and knowing what issues should be researched. This journal article review examines and demystifies the research process. This is a positive, motivating, and practical approach to research. Read on and share your thoughts with the editorial staff!
SN - 1064-3842
AD - Nurse Consultant, ENT Devices Branch, Food and Drug Administration, Bethesda, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106828084
T1 - Prevalence of safer needle devices and factors associated with their adoption: results of a national hospital survey.
AU - Sinclair RC
AU - Maxfield A
AU - Marks EL
AU - Thompson DR
AU - Gershon RRM
Y1 - 2002/07//Jul/Aug2002
N1 - Accession Number: 106828084. Language: English. Entry Date: 20030502. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Needlestick Injuries -- Prevention and Control
KW - Equipment Safety -- Standards
KW - Occupational Exposure -- Prevention and Control
KW - Protective Devices -- Utilization
KW - Diffusion of Innovation
KW - Infection Control -- Standards
KW - Occupational Safety -- Standards
KW - Syringes -- Standards
KW - Surveys
KW - United States
KW - Random Sample
KW - Interviews
KW - Attitude of Health Personnel
KW - Secondary Analysis
KW - Practice Guidelines
KW - Organizational Compliance
KW - Scales
KW - Correlation Coefficient
KW - Multiple Regression
KW - Logistic Regression
KW - United States Occupational Safety and Health Administration
KW - Blood Specimen Collection -- Equipment and Supplies
KW - Infusions, Intravenous -- Equipment and Supplies
KW - Needles -- Standards
KW - Bloodborne Pathogens -- Transmission
KW - Information Resources
KW - Protective Devices -- Economics
KW - Cross Infection -- Prevention and Control
KW - Human
SP - 340
EP - 349
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 117
IS - 4
PB - Sage Publications Inc.
AB - OBJECTIVES: In this study, we collected and analyzed the first data available on the extent of the adoption of safer needle devices (engineered sharps injury protections [ESIPs]) by U.S. hospitals and on the degree to which selected factors influence the use of this technology. METHODS: We gathered data via a telephone survey of a random sample of 494 U.S. hospitals from November 1999 through February 2000. RESULTS: Although 83% of the sample reported some ESIP adoption, adoption was inconsistent across types of devices. All of the appropriate units in 52% of the facilities had adopted needleless intravenous delivery systems, but the hospitals used other types of ESIPs less often. A respondent's perception that the cost of ESIPs would not be a problem for the hospital was the best predictor of adoption of ESIPs in the facility, explaining 8% of the variance. Other predictors of adoption included the size of the hospital and the presence or absence of state legislative activity on the needlestick issue. CONCLUSIONS: Smaller hospitals may require special encouragement and assistance from outside sources to adopt expensive risk-reduction innovations such as ESIPs. Although use of ESIPs is the mandated and preferred way to protect workers from needlesticks, complete adoption of this technology will depend on the support of the social systems in which it is used and the people who use it.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy., Cincinnati, OH 45226; rsinclair@cdc.gov
U2 - PMID: 12477915.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106828084&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106802297
T1 - Reducing disparities through culturally competent health care: an analysis of the business case.
AU - Brach C
AU - Fraser I
Y1 - 2002///Summer2002
N1 - Accession Number: 106802297. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Health Services Administration; Nursing; Peer Reviewed; USA. NLM UID: 9306156.
KW - Primary Health Care
KW - Cultural Diversity
KW - Cultural Sensitivity
KW - Minority Groups
KW - Cost Benefit Analysis
KW - United States
SP - 15
EP - 28
JO - Quality Management in Health Care
JF - Quality Management in Health Care
JA - QUAL MANAGE HEALTH CARE
VL - 10
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1063-8628
AD - Health Policy Researcher, Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 12938253.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106802297&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Haberny, Kathleen A.
AU - Paule, Merle G.
AU - Scallet, Andrew C.
AU - Sistare, Frank D.
AU - Lester, David S.
AU - Hanig, Joseph P.
AU - Slikker Jr., William
T1 - Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/07//
VL - 68
IS - 1
M3 - Article
SP - 9
EP - 17
PB - Oxford University Press / USA
SN - 10966080
AB - The NMDA receptor has been widely investigated in recent years as a target for the pharmacological management of seizures, pain and a variety of neurological disorders. Its role in normal central nervous system (CNS) activity and development, as well as in the development of CNS abnormalities and neurodegeneration has also been of interest. The NMDA receptor is one of three pharmacologically distinct subtypes of ionotropic receptor channels that are sensitive to the endogenous excitatory amino acid, L-glutamate. The ontogeny of the NMDA receptor, a multiple tetrameric and heteromeric channel complex with at least six known subunits, is controlled by three gene families and varies in developmental profile with species and regional brain area. NMDA receptors play a role in excitatory synaptic transmission, in the activity-dependent synaptic plasticity underlying learning and memory, and in pre- and postnatal CNS development, including brain cell differentiation, axonal growth and degeneration of unused neurons. The results of recent studies suggest that sustained alteration of NMDA receptor activation during critical periods of development may have deleterious effects on normal CNS development and function. Neonatal rats administered the NMDA receptor antagonists 2-amino-5-phosphonovalerate (AP5) and MK-801 during the first two weeks of life develop abnormal axonal arborization in the retinal connections to the superior colliculus, interfering with normal visual responses. Results from monkey studies suggest that chronic developmental exposure to high doses of a NMDA antagonist, remacemide, has pronounced and long-lasting effects on learning. Recent findings indicate that if NMDA receptors are blocked during a specific period in neonatal life (first two weeks postnatally in the rat), massive apoptotic neurodegeneration results, due not to excitotoxic overstimulation of neurons but to deprivation of stimulation. These observations require further laboratory evidence and support in order to establish their relevance to drug-induced human neurodevelopmental concerns. It is necessary to investigate the relevance of these findings in other animal species in addition to the rat, most notably, nonhuman primates, where neuronal cytoarchitecture and development are significantly different than the rodent but more like the human. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Apoptosis
KW - Methyl aspartate
KW - Central nervous system
KW - Spasms
KW - Neural stimulation
KW - apoptosis
KW - brain cell differentiation
KW - CNS development
KW - N-methyl-D-aspartate
KW - NMDA receptor
KW - synaptic plasticity
N1 - Accession Number: 44626774; Haberny, Kathleen A. 1; Paule, Merle G. 2; Scallet, Andrew C. 2; Sistare, Frank D. 1; Lester, David S. 1; Hanig, Joseph P. 1; Slikker Jr., William 2; Email Address: wslikker@nctr.fda.gov; Affiliations: 1: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857; 2: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079; Issue Info: Jul2002, Vol. 68 Issue 1, p9; Thesaurus Term: Apoptosis; Subject Term: Methyl aspartate; Subject Term: Central nervous system; Subject Term: Spasms; Subject Term: Neural stimulation; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: brain cell differentiation; Author-Supplied Keyword: CNS development; Author-Supplied Keyword: N-methyl-D-aspartate; Author-Supplied Keyword: NMDA receptor; Author-Supplied Keyword: synaptic plasticity; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shvedova, Anna A.
AU - Kisin, Elena
AU - Murray, Ashley
AU - Smith, Charlotte
AU - Castranova, Vincent
AU - Kommineni, Choudari
T1 - Enhanced oxidative stress in the skin of vitamin E deficient mice exposed to semisynthetic metal working fluids
JO - Toxicology
JF - Toxicology
Y1 - 2002/07//
VL - 176
IS - 1/2
M3 - Article
SP - 135
SN - 0300483X
AB - Metal working fluids (MWFs) are widely used in industry for metal cutting, drilling, shaping, lubricating, and milling. Many occupational health concerns have arisen for workers exposed to MWFs. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we have shown that dermal exposure of female and male B6C3F1 mice to 5% MWFs for 3 months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWFs also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate whether preexisting oxidative stress in the skin exacerbated mast cell influx after MWFs treatment. Oxidative stress in the skin of B6C3F1 mice was generated by dietary vitamin E deprivation. Mice were given vitamin E deficient (5–10 IV/kg of vitamin E) or basal (50 IV/kg of vitamin E) diets for 34 weeks. Topical treatment with MWFs (100 μl, 30%) started after 18 weeks of alimentary vitamin E deprivation. Histology of the skin after 16 weeks of exposure to MWFs revealed a 53% increase in mast cell accumulation in vitamin E deficient diets compared to mice given a vitamin E sufficient diet. Total antioxidant reserve in skin of vitamin E deprived mice treated with MWFs was decreased by 66% as compared to those mice given a vitamin E sufficient diet. GSH and protein thiols in the dermis of vitamin E deprived mice exposed to MWFs were also decreased 39 and 42%, respectively, as compared to mice given basal diet. This study clearly delineates the role of oxidative stress in enhancing mast cell accumulation caused by topical exposure to MWFs. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vitamin E
KW - Skin -- Inflammation
KW - GSH
KW - Metal working fluids
KW - Oxidative stress
KW - skin (Inflammation)
N1 - Accession Number: 7821774; Shvedova, Anna A.; Kisin, Elena 1; Murray, Ashley 1; Smith, Charlotte 1; Castranova, Vincent 1; Kommineni, Choudari 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mail Stop 2015, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Jul2002, Vol. 176 Issue 1/2, p135; Subject Term: Vitamin E; Subject Term: Skin -- Inflammation; Author-Supplied Keyword: GSH; Author-Supplied Keyword: Metal working fluids; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: skin (Inflammation); Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106975570
T1 - Healthy People 2010 -- leading health indicators for women.
AU - Maiese DR
Y1 - 2002/07//Jul/Aug2002
N1 - Accession Number: 106975570. Language: English. Entry Date: 20021108. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Women's Health
KW - Attitude to Health
KW - Health Behavior
KW - Health Status Indicators
KW - Healthy People 2010
KW - Clinical Indicators
KW - Age Factors
KW - Sex Factors
KW - United States
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Female
SP - 155
EP - 164
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 12
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Office of Women's Health, Health Resources and Services Administration, US Dept of Health and Human Services, Rockville, MD
U2 - PMID: 12093580.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106975570&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2015-50164-029
AN - 2015-50164-029
AU - Zhang, Xia
AU - Cui, Shu-Sen
AU - Wallace, Amy E.
AU - Hannesson, Darren K.
AU - Schmued, Larry C.
AU - Saucier, Deborah M.
AU - Honer, William G.
AU - Corcoran, Michael E.
T1 - Relations between brain pathology and temporal lobe epilepsy.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2002/07//
VL - 22
IS - 14
SP - 6052
EP - 6061
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Zhang, Xia, Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, A114 Medical Research Building, 103 Wiggins Road, Saskatoon, SK, Canada, S7N 5E4
N1 - Accession Number: 2015-50164-029. Partial author list: First Author & Affiliation: Zhang, Xia; Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada. Release Date: 20151228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Zhang, Xia. Major Descriptor: Epilepsy; Hippocampus; Temporal Lobe. Minor Descriptor: Brain; Neurons; Rats; Seizures. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2002. Publication History: Accepted Date: Apr 25, 2002; First Submitted Date: Apr 9, 2002. Copyright Statement: Society for Neuroscience. 2002.
AB - Temporal lobe epilepsy, the most common type of epilepsy in adult humans, is characterized clinically by the progressive development of spontaneous recurrent seizures of temporal lobe origin and pathologically by hippocampal neuronal loss and mossy fiber sprouting. In this study, we sought to test the prominent hypothesis that neuronal loss and mossy fiber sprouting play a critical role in the genesis and progression of temporal lobe epilepsy. Rats receiving a single kainic acid injection experienced a single sustained episode of epileptic status with massive neuronal loss and mossy fiber sprouting, whereas rats receiving triple kainic acid injections experienced two priming episodes and one sustained episode of epileptic status with no detectable neuronal loss and mossy fiber sprouting. Early in the process of chronic seizure development, primed rats that failed to show detectable neuronal loss and mossy fiber sprouting exhibited a starting date and a frequency of spontaneous recurrent seizures similar to those of nonprimed rats that showed massive neuronal loss and mossy fiber sprouting. However, nonprimed rats displayed significantly prolonged episodes of spontaneous recurrent seizures over the whole process of chronic seizure development and more frequent severe seizures later in the process. Similar results were observed in both Fischer-344 and Wistar rats as well as in the rat pilocarpine preparation of temporal lobe epilepsy. These results fail to reveal a relation between neuronal loss–mossy fiber sprouting and the genesis of temporal lobe epilepsy but suggest that neuronal loss, mossy fiber sprouting, or both contribute to the intensification of chronic seizures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mossy fiber sprouting
KW - neuronal loss
KW - epilepsy/ physiopathology
KW - kainic acid
KW - hippocampal/physiopathology
KW - temporal lobe epilepsy
KW - 2002
KW - Epilepsy
KW - Hippocampus
KW - Temporal Lobe
KW - Brain
KW - Neurons
KW - Rats
KW - Seizures
KW - 2002
U1 - Sponsor: Canadian Institutes of Health Research, Canada. Recipients: Zhang, Xia; Honer, William G.; Corcoran, Michael E.
U1 - Sponsor: Health Services Utilization and Research Commission (HSURC) of Saskatchewan, Canada. Recipients: Zhang, Xia
U1 - Sponsor: HSURC, Canada. Other Details: Postdoctoral fellowship. Recipients: Cui, Shu-Sen
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-50164-029&site=ehost-live&scope=site
UR - michael.corcoran@usask.ca
UR - zhangxia@duke.usask.ca
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106982595
T1 - The importance of outcomes research in pediatric emergency medicine.
AU - Clancy CM
AU - Dougherty D
AU - Walker E
Y1 - 2002/07/02/2002 Jul-Aug Suppl
N1 - Accession Number: 106982595. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2002 Jul-Aug Suppl. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Emergency Care -- In Infancy and Childhood
KW - Outcomes Research
KW - Emergency Service -- Utilization
KW - Outcomes (Health Care)
KW - Research Priorities
KW - Child
KW - Adolescence
SP - 293
EP - 300
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 2
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - Applying the methods and tools of outcomes research, 'evaluation of the impact of health care on the health outcomes or 'end results' of patients and populations,' to the clinical domain of emergency services for children offers an important strategic opportunity for addressing the questions that confront all health care services: What works? For which patients? At what cost? From whose perspective? Although the important questions to address are extensive, much of the intersection between emergency services and outcomes research remains unexplored. Important challenges for researchers intrigued by the opportunities at this intersection of fields include: 1) clear definition of the scope of emergency services; 2) consideration of the appropriate end-point of emergency services-the entire episode of illness and/or services provided within the emergency setting; 3) selection and development of measures that incorporate children's and families' perspectives; and 4) a clear focus on linking research findings with strategies for improving outcomes and informed decision making. This essay will provide an overview of accomplishments and challenges from the field of outcomes research, suggest important opportunities for applying existing methods to emergency medical services for children, and identify potential career paths for current and future investigators.
SN - 1530-1567
AD - Agency for Healthcare Research and Quality, US Department of Health and Human Services, 2101 East Jefferson St, Rockville, MD 20852; ddougher@ahrq.gov
U2 - PMID: 12135403.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106982595&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106982620
T1 - Patient/parent assessment of the quality of care.
AU - Darby C
Y1 - 2002/07/02/2002 Jul-Aug Suppl
N1 - Accession Number: 106982620. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2002 Jul-Aug Suppl. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Quality of Health Care -- Evaluation
KW - Patient Satisfaction
KW - Professional-Patient Relations
KW - Self Report
KW - Emergency Service
KW - Emergency Care -- Psychosocial Factors -- In Infancy and Childhood
KW - Child
SP - 345
EP - 348
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 2
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - Providing patient-centered care is an accepted goal in medicine today. Focusing on the patient has drawn attention to the importance of the interpersonal aspects of care, such as communication between the health care provider and patient, or in the case of health care for children, the parent and child. Patients or parents may be the best or only source of information for assessing the personal aspects of care. In research on children, parents generally report on and evaluate the care. Assessing the interpersonal aspects of care has traditionally been referred to as the measurement of patient satisfaction. The varying expectations of patients and the presence of a ceiling effect on the measures often confound the use of patient satisfaction measures for evaluating the quality of care. One trend is to ask respondents to report on the interpersonal aspects of care, rather than to respond about their level of satisfaction. Studies on the assessment of the interpersonal aspects of health care in emergency departments for children are not plentiful. However, research provides some insight into ways in which emergency departments might improve interpersonal aspects of care for children. These include providing a clear picture to patients and parents of what to expect regarding the length of time they will have to wait, taking a caring approach with children and their parents, and explaining clearly to parents what they need to do to care for the child after discharge.
SN - 1530-1567
AD - Agency for Healthcare Research and Quality, Executive Blvd, Suite 200, Rockville, MD 20852; cdarby@ahrq.gov
U2 - PMID: 12135410.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106982620&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 119411659
T1 - From the Food and Drug Administration.
AU - Crawford, Lester M Jr
Y1 - 2002/07/03/
N1 - Accession Number: 119411659. Language: English. Entry Date: 20030103. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Medicine, Herbal
KW - Hypertension, Pulmonary -- Drug Therapy
KW - Vasodilator Agents -- Therapeutic Use
KW - Drug Interactions
KW - Epoprostenol -- Therapeutic Use
KW - United States Food and Drug Administration -- Standards
KW - Industry -- Standards
KW - Advertising -- Standards
KW - United States
KW - Policy Making
KW - Epoprostenol -- Analogs and Derivatives
SP - 36
EP - 36
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 288
IS - 1
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - US Food and Drug Administration, USA
U2 - PMID: 12090852.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=119411659&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kojima, Yoshitsugu
AU - Xin, Ke-Qin
AU - Ooki, Takaaki
AU - Hamajima, Kenji
AU - Oikawa, Tomohiro
AU - Shinoda, Kaori
AU - Ozaki, Tomomi
AU - Hoshino, Yuka
AU - Jounai, Nao
AU - Nakazawa, Masatoshi
AU - Klinman, Dennis
AU - Okuda, Kenji
T1 - Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2002/07/26/
VL - 20
IS - 23/24
M3 - Article
SP - 2857
SN - 0264410X
AB - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs trigger an immune response characterized by the activation of B cells, NK cells and monocytes/macrophages. Based on evidence that the immunogenicity of DNA vaccines can be augmented by the addition of CpG motifs, 5–20 additional CpG motifs were cloned into a pUC-derived plasmid. Treating bone-marrow derived dendritic cells (BM-DCs) with CpG-enriched plasmids in vitro boosted their expressions of MHC class II molecules, the CD40 and CD86 activation markers. Co-administering the CpG-enriched plasmids with a DNA vaccine encoding the envelope glycoprotein of HIV to BALB/c mice significantly increased HIV-specific cell mediated and humoral immunity. A significant boost was observed when the CpG plasmid was administered either 2 or 4 days after DNA vaccination. Plasmids containing 20 CpG copies were the most effective immune enhancers both in vitro and in vivo. These results suggest that plasmids containing multiple CpG motifs may improve the immunogenicity of DNA vaccines. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA vaccines
KW - Dendritic cells
KW - CpG motif
KW - DNA vaccine
KW - HIV
N1 - Accession Number: 7844293; Kojima, Yoshitsugu 1; Xin, Ke-Qin 1; Ooki, Takaaki 1; Hamajima, Kenji 1; Oikawa, Tomohiro 1; Shinoda, Kaori 1; Ozaki, Tomomi 1; Hoshino, Yuka 1; Jounai, Nao 1; Nakazawa, Masatoshi 2; Klinman, Dennis 3; Okuda, Kenji 1; Email Address: kokuda@med.yokohama-cu.ac.jp; Affiliations: 1: Department of Bacteriology, University School of Medicine, Yokohama City, Yokohama 236-0004, Japan; 2: Department of Parasitology, University School of Medicine, Yokohama City, Yokohama 236-0004, Japan; 3: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Jul2002, Vol. 20 Issue 23/24, p2857; Subject Term: DNA vaccines; Subject Term: Dendritic cells; Author-Supplied Keyword: CpG motif; Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: HIV; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106538800
T1 - FDA's role in responding to drug shortages.
AU - Jensen V
AU - Kimzey LM
AU - Goldberger MJ
Y1 - 2002/08//8/1/2002
N1 - Accession Number: 106538800. Language: English. Entry Date: 20081219. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - United States Food and Drug Administration
KW - Drugs, Prescription
KW - Health Services Accessibility
KW - United States
SP - 1423
EP - 1425
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 59
IS - 15
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Drug Shortage Project Manager, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 12166041.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106538800&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Berg, AO;
AU - Preventive Services Task Force;
AU - Allan, JD;
AU - Frame, PS;
AU - Woolf, SH;
AU - et al;
T1 - Screening for bacterial vaginosis in pregnancy: Recommendations and rationale
CT - Screening for bacterial vaginosis in pregnancy: Recommendations and rationale
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 2002/08/01/
VL - 102
IS - Aug
SP - 91
EP - 93
SN - 0002936X
AD - Reprints: Care of Atkins D, Agcy Healthcare Res & Qual, 6010 Execut Blvd,Suite 300, Rockville, MD 20852, USA uspstf@ahrq.gov
AD - Univ Washington, Dept Family Med, Seattle, WA 98195, USA
N1 - Accession Number: 39-16919; Language: English; References: 5; Journal Coden: AJNUAK; Human Indicator: Yes; Section Heading: Pharmacology; ToxicityDrug Evaluations
N2 - The guidelines issued by the U.S. Preventive Services Task Force (USPSTF) for routinely screening high-risk pregnant women for bacterial vaginosis (BV) are presented as well as the epidemiology and clinical consequences of BV, the accuracy and reliability of the screening tests used in most studies, the effectiveness of antibiotic treatment of bacterial vaginosis and the potential adverse effects of screening and treatment for BV.
KW - Guidelines--vaginosis;
KW - Pregnancy--vaginosis;
KW - Tests--vaginosis;
KW - Epidemiology--vaginosis;
KW - Antibiotics--vaginosis;
KW - Toxicity--antibiotics;
KW - Vaginosis--guidelines;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=39-16919&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Blondel, Béatrice
AU - Kogan, Michael D.
AU - Alexander, Greg R.
AU - Dattani, Nirupa
AU - Kramer, Michael S.
AU - Macfarlane, Alison
AU - Shi Wu Wen
T1 - The Impact of the Increasing Number of Multiple Births on the Rates of Preterm Birth and Low Birthweight: An International Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2002/08//
VL - 92
IS - 8
M3 - Article
SP - 1323
EP - 1330
PB - American Public Health Association
SN - 00900036
AB - Objectives. We studied the effects of twins and triplets on perinatal health indicators in the overall population in the 1980s and 1990s in Canada, England and Wales, France, and the United States. Methods. Data were derived mostly from live birth registration. We used rates, relative risks, and population attributable risks for twins and triplets separately. Results. In each country, the increase in multiple births, and the increase in preterm delivery among multiple births, contributed almost equally to the rise in or stabilization of the overall rates of preterm delivery. Twins contributed a much larger proportion of the preterm deliveries and low-birthweight newborns than did triplets. Conclusions. Twins have a major population-based impact on the trends of perinatal health indicators. (Am J Public Health. 2002;92:1323-1330) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Multiple birth
KW - Twins
KW - Triplets
KW - Premature labor
KW - Low birth weight
N1 - Accession Number: 7069762; Blondel, Béatrice 1; Email Address: blondel@vif.inserm.Fr; Kogan, Michael D. 2; Alexander, Greg R. 3; Dattani, Nirupa 4; Kramer, Michael S. 5,6; Macfarlane, Alison 7; Shi Wu Wen 8; Affiliations: 1: Epidemiological Research Unit on Perinatal Health and Women's Health, National Institute for Health and Medical Resarch, Villejuif, France; 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; 3: Department of Maternal and Child Health, University of Alabama, Birmingham; 4: Office for National Statistics, London, England; 5: Department of Pediatrics, McGill University, Montreal, Quebec; 6: Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec; 7: National Perinatal Epidemiology Unit, Oxford, England; 8: Bureau of Reproductive and Child Health, Centre for Healthy Human Development, Ottawa, Ontario; Issue Info: Aug2002, Vol. 92 Issue 8, p1323; Subject Term: Multiple birth; Subject Term: Twins; Subject Term: Triplets; Subject Term: Premature labor; Subject Term: Low birth weight; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article; Full Text Word Count: 6027
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Carnethon, Mercedes R.
AU - Palaniappan, Latha P.
AU - Burchfiel, Cecil M.
AU - Brancati, Frederick L.
AU - Fortmann, Stephen P.
T1 - Serum Insulin, Obesity, and the Incidence of Type 2 Diabetes in Black and White Adults.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2002/08//
VL - 25
IS - 8
M3 - Article
SP - 1358
EP - 1364
SN - 01495992
AB - OBJECTIVE -- In this study, we tested the hypothesis that fasting serum insulin is higher in nonobese black adults than in white adults and that high fasting insulin predicts type 2 diabetes equally well in both groups. RESEARCH DESIGN AND METHODS -- At the baseline examination (1987-1989) of the Atherosclerosis Risk in Communities Study, fasting insulin and BMI were measured in 13,416 black and white men and women without diabetes. Participants were examined at years 3, 6, and 9 for incident diabetes based on fasting glucose and American Diabetes Association criteria. RESULTS -- Fasting insulin was 19.7 pmol/l higher among nonobese (BM1 <30 kg/m²) black women compared with white women (race and obesity interaction term, P < 0.01). There were no differences among men. Among nonobese women, the relative risk for developing diabetes was similar between racial groups: 1.4 (95% CI 1.2-1.5) and 1.3 (1.2-1.4) per 60 pmol/l increase in insulin (P < 0.01) for black and white women, respectively (interaction term, P = 0.6). Findings were similar among men. Adjusting for established risk factors did not attenuate this association. CONCLUSIONS -- Nonobese black women have higher fasting insulin levels than nonobese white women, and fasting insulin is an equally strong predictor of diabetes in both groups. These results suggest one mechanism to explain the excess incidence of diabetes in nonobese black women but do not explain the excess among black men. Future research should evaluate additional factors: genetic, environmental, or the combination of both, which might explain higher fasting insulin among black women when compared with white women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - INSULIN -- Pathophysiology
KW - SERUM
KW - FASTING -- Physiological aspects
N1 - Accession Number: 7122572; Carnethon, Mercedes R. 1; Palaniappan, Latha P. 1; Burchfiel, Cecil M. 2; Brancati, Frederick L. 3; Fortmann, Stephen P. 1; Source Information: Aug2002, Vol. 25 Issue 8, p1358; Subject: DIABETES; Subject: INSULIN -- Pathophysiology; Subject: SERUM; Subject: FASTING -- Physiological aspects; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 4594
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DB - hch
ER -
TY - JOUR
AU - Ravishankar, Sadhana
AU - Fleischman, Gregory J.
AU - Balasubramaniam, V. M.
T1 - The inactivation of Escherichia coli O157:H7 during pulsed electric field (PEF) treatment in a static chamber
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/08//
VL - 19
IS - 4
M3 - Article
SP - 351
SN - 07400020
AB - The inactivation of Escherichia coli O157:H7 by pulsed electric field (PEF) processing as a function of electric field strength (15–30 kV cm−1), pulse number (1–20), temperature (5–65°C) and pH (3·5 and 6·8) was studied using a commercially available pulser, a static chamber and gellan gum gel as a suspension medium. The custom-designed static chamber achieved near-isothermal treatment conditions while eliminating flow field effects. Gellan gum gel was used to suspend the bacteria for treatment. It allowed uniform distribution of bacteria and neither inhibited nor promoted bacterial growth. The combination of equipment design and experimental protocol allowed the contribution of electrical (PEF) and thermal energy to be measured separately. In water-based gel, a maximum of 3 log reductions were achieved by PEF energy. Greater inactivation was observed at a treatment temperature of 55°C, but the additional inactivation was attributable entirely to thermal energy. Microbial injury was also observed at this temperature. At 60°C and above, complete inactivation was achieved, but this was attributable entirely to thermal energy. In water-based gellan gum gel adjusted to pH 3·5, again a 3 log reduction was achieved by PEF. In gel made from freshly squeezed apple juice naturally having the same pH, however, a maximum of 1·5 log reduction was observed. Published by Elsevier Science Ltd. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli O157:H7
KW - Electric fields
N1 - Accession Number: 8508316; Ravishankar, Sadhana 1; Fleischman, Gregory J. 2; Balasubramaniam, V. M. 1; Affiliations: 1: The National Center for Food Safety and Technology, Illinois Institute of Technology, Moffett Campus, 6502 South Archer Road, Summit-Argo, Ilinois, 60501, USA; 2: Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Ilinois, 60501, USA; Issue Info: Aug2002, Vol. 19 Issue 4, p351; Subject Term: Escherichia coli O157:H7; Subject Term: Electric fields; Number of Pages: 11p; Document Type: Article
L3 - 10.1006/fmic.2002.0484
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105822653
T1 - Risk assessment in regulatory policy making for human and veterinary public health.
AU - Lathers CM
Y1 - 2002/08//
N1 - Accession Number: 105822653. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Policy Making
KW - Public Health -- Methods
KW - Public Health -- Standards
KW - Animals
KW - Antibiotics -- Administration and Dosage
KW - Antibiotics -- Adverse Effects
KW - Antibiotics -- Pharmacodynamics
KW - Antibiotics -- Supply and Distribution
KW - Drug Administration
KW - Drug Resistance, Microbial
KW - Drugs -- Adverse Effects
KW - Drugs -- Pharmacodynamics
KW - Drugs
KW - Food Contamination -- Prevention and Control
KW - Food Handling -- Standards
KW - Risk Assessment
SP - 846
EP - 866
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 8
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Risk assessment is the method of systematically identifying and assessing factors that influence the probability and consequences of a negative event occurring. One responsibility of veterinary medicine is to protect animal and human health. Food animal production uses antibiotics to enhance production. Regulators evaluate new production technology to ensure animal safety and safe, edible products and to make public policy decisions by assessing risks/benefits. The U.S. Food and Drug Administration, Center for Veterinary Medicine's (CVM's) first risk assessment addressed the potential human health impact of campylobacter effects associated with the use of fluoroquinolines in food-producing animals. CVM used the Monte Carlo method to estimate risk byprobability distributions that reflect the uncertainty and variability in the data used for the assessment. Enterococci faecium is a species more likely to be resistant to antibiotics of last resort. Effective control of multidrug-resistant enterococci will requirea better understanding of the transfer of E. faeciumfrom animals to humans and the interaction between E. faecium, the hospital environment, and humans; prudent antibiotic use; better contact isolation in hospitals; and better surveillance. CVM will model these factors in a second, more complex risk assessment designed to examine the indirect transfer of resistance from animals to humans. Use of risk assessments allows researchers, the industry, regulatory authorities, and educators to make better policy decisions regarding antimicrobial use in food animals and humans and the development of resistance. Today the question of whether the use of antimicrobials for growth enhancement infood animals should or should not be terminated for the benefit of human health remains unresolved.
SN - 0091-2700
AD - Center for Veterinary Medicine, US Food and Drug Administration, Rockville, Maryland 20855, USA.
U2 - PMID: 12162467.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106830663
T1 - Practicing palliative care in resource-poor settings.
AU - O'Neill JF
AU - Romaguera R
AU - Parham D
AU - Marconi K
Y1 - 2002/08//
N1 - Accession Number: 106830663. Language: English. Entry Date: 20030509. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8605836.
KW - HIV Infections
KW - Palliative Care
KW - Hospice Care
KW - Health Services Accessibility
KW - Medically Underserved
KW - Medically Underserved Area
KW - Palliative Care -- Organizations
KW - Family Centered Care
KW - HIV Infections -- South Africa
KW - Hospice Care -- South Africa
KW - United States Department of Health and Human Services
KW - United States
KW - South Africa
SP - 148
EP - 151
JO - Journal of Pain & Symptom Management
JF - Journal of Pain & Symptom Management
JA - J PAIN SYMPTOM MANAGE
VL - 24
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 0885-3924
AD - United States Department of Health and Human Services, Health Resources and Services Administration, Washington, DC
U2 - PMID: 12231132.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Archer, Sujata L.
AU - Greenlund, Kurt J.
AU - Casper, Michele L.
AU - Rith-Najarian, Stephen
AU - Croft, Janet B.
T1 - Associations of Community-based Health Education Programs with Food Habits and Cardiovascular Disease Risk Factors Among Native Americans with Diabetes: The Inter-Tribal Heart Project, 1992 to 1994
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2002/08//
VL - 102
IS - 8
M3 - Article
SP - 1132
EP - 1135
SN - 00028223
N1 - Accession Number: 19668931; Archer, Sujata L. 1; Greenlund, Kurt J. 2; Casper, Michele L. 2; Rith-Najarian, Stephen 3; Croft, Janet B. 2; Affiliations: 1: S. L. Archer is a research assistant professor in the Department of Preventive Medicine, Northwestern University Medical School, Chicago, III, USA; 2: K. J. Greenlund, M. L. Casper, and J. B. Croft are epidemiologists with the Cardiovascular Health Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga. USA; 3: S. Rith-Najarian is a diabetes consultant with the Bemidji Indian Health Service, Bemidji Area Office, Bemidji, Minn. USA.; Issue Info: Aug2002, Vol. 102 Issue 8, p1132; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S0002-8223(02)90251-8
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DB - eih
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Hubbs, Ann F.
AU - Robinson, Victor A.
AU - Battelli, Lori A.
AU - Greskevitch, Mark
AU - Barger, Mark
AU - Landsittel, Douglas
AU - Jones, William
AU - Castranova, Vincent
T1 - COMPARATIVE PULMONARY TOXICITY OF BLASTING SAND AND FIVE SUBSTITUTE ABRASIVE BLASTING AGENTS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/08//
VL - 65
IS - 16
M3 - Article
SP - 1121
EP - 1140
SN - 15287394
AB - Blasting sand is used for abrasive blasting, but its inhalation is associated with pulmonary inflammation and fibrosis. Consequently, safer substitute materials for blasting sand are needed. In a previous study from this laboratory, the comparative pulmonary toxicity of five abrasive blasting substitutes and blasting sand was reported. In this study, the pulmonary toxicity of blasting sand was compared to five additional abrasive blasting substitutes: steel grit, copper slag, nickel slag, crushed glass, and olivine. Exposed rats received by intratracheal instillation 10 mg of respirable-size particles of blasting sand or an abrasive blasting substitute, while controls were instilled with vehicle. Pulmonary inflammation, damage, and fibrosis were examined 28 d postexposure. Pulmonary inflammation was monitored by determining bronchoalveolar lavage polymorphonuclear cell counts and alveolar macrophage activation by chemiluminescence. Pulmonary damage was assessed by acellular bronchoalveolar (BAL) fluid serum albumin concentrations and lactate dehydrogenase activities. Histological examination of lung tissue samples was made to assess the severity and distribution of pulmonary fibrosis, alveolitis, and alveolar epithelial cell hypertrophy and hyperplasia. In comparison to blasting sand, olivine exposed rats had higher levels of pulmonary inflammation and damage with a similar level of fibrosis. Steel grit-exposed rats had lower levels of pulmonary inflammation and damage, and did not develop fibrosis. However, steel grit-exposed rats had a level of epithelial cell hypertrophy and hyperplasia similar to blasting sand. The other abrasive blasting substitutes gave a mixed profile of toxicity. The data demonstrate that steel grit produced less acute pulmonary toxicity than blasting sand or any of the other abrasive blasting substitutes. Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sand
KW - Copper
KW - Nickel
KW - Steel
KW - Glass
N1 - Accession Number: 7008843; Porter, Dale W. 1; Hubbs, Ann F. 1; Robinson, Victor A. 1; Battelli, Lori A. 1; Greskevitch, Mark 2; Barger, Mark 1; Landsittel, Douglas 1; Jones, William 2; Castranova, Vincent 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: 2002, Vol. 65 Issue 16, p1121; Thesaurus Term: Sand; Thesaurus Term: Copper; Thesaurus Term: Nickel; Subject Term: Steel; Subject Term: Glass; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; NAICS/Industry Codes: 416340 Paint, glass and wallpaper merchant wholesalers; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 238150 Glass and Glazing Contractors; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 484232 Dry bulk materials trucking, long distance; NAICS/Industry Codes: 484222 Dry bulk materials trucking, local; NAICS/Industry Codes: 423320 Brick, Stone, and Related Construction Material Merchant Wholesalers; NAICS/Industry Codes: 416390 Other specialty-line building supplies merchant wholesalers; NAICS/Industry Codes: 212321 Construction Sand and Gravel Mining; NAICS/Industry Codes: 331221 Rolled Steel Shape Manufacturing; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 20p; Document Type: Article
L3 - 10.1080/152873902760125363
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Hubbs, Ann F.
AU - Robinson, Victor A.
AU - Battelli, Lori A.
AU - Greskevitch, Mark
AU - Barger, Mark
AU - Landsittel, Douglas
AU - Jones, William
AU - Castranova, Vincent
T1 - COMPARATIVE PULMONARY TOXICITY OF BLASTING SAND AND FIVE SUBSTITUTE ABRASIVE BLASTING AGENTS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/08//
VL - 65
IS - 16
M3 - Article
SP - 1121
EP - 1140
SN - 15287394
AB - Blasting sand is used for abrasive blasting, but its inhalation is associated with pulmonary inflammation and fibrosis. Consequently, safer substitute materials for blasting sand are needed. In a previous study from this laboratory, the comparative pulmonary toxicity of five abrasive blasting substitutes and blasting sand was reported. In this study, the pulmonary toxicity of blasting sand was compared to five additional abrasive blasting substitutes: steel grit, copper slag, nickel slag, crushed glass, and olivine. Exposed rats received by intratracheal instillation 10 mg of respirable-size particles of blasting sand or an abrasive blasting substitute, while controls were instilled with vehicle. Pulmonary inflammation, damage, and fibrosis were examined 28 d postexposure. Pulmonary inflammation was monitored by determining bronchoalveolar lavage polymorphonuclear cell counts and alveolar macrophage activation by chemiluminescence. Pulmonary damage was assessed by acellular bronchoalveolar (BAL) fluid serum albumin concentrations and lactate dehydrogenase activities. Histological examination of lung tissue samples was made to assess the severity and distribution of pulmonary fibrosis, alveolitis, and alveolar epithelial cell hypertrophy and hyperplasia. In comparison to blasting sand, olivine exposed rats had higher levels of pulmonary inflammation and damage with a similar level of fibrosis. Steel grit-exposed rats had lower levels of pulmonary inflammation and damage, and did not develop fibrosis. However, steel grit-exposed rats had a level of epithelial cell hypertrophy and hyperplasia similar to blasting sand. The other abrasive blasting substitutes gave a mixed profile of toxicity. The data demonstrate that steel grit produced less acute pulmonary toxicity than blasting sand or any of the other abrasive blasting substitutes. Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAND
KW - STEEL
KW - COPPER
KW - NICKEL
KW - GLASS
N1 - Accession Number: 7008843; Porter, Dale W. 1; Hubbs, Ann F. 1; Robinson, Victor A. 1; Battelli, Lori A. 1; Greskevitch, Mark 2; Barger, Mark 1; Landsittel, Douglas 1; Jones, William 2; Castranova, Vincent 1; Source Information: 2002, Vol. 65 Issue 16, p1121; Subject: SAND; Subject: STEEL; Subject: COPPER; Subject: NICKEL; Subject: GLASS; Number of Pages: 20p; Document Type: Article
L3 - 10.1080/152873902760125363
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106817795
T1 - Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.
AU - Kreiss K
AU - Gomaa A
AU - Kullman G
AU - Fedan K
AU - Simoes EJ
AU - Enright PL
Y1 - 2002/08//8/1/2002
N1 - Accession Number: 106817795. Language: English. Entry Date: 20030328. Revision Date: 20150711. Publication Type: Journal Article; case study; research; tables/charts. Commentary: Schlachter EN. Popcorn worker's lung. (N ENGL J MED) 8/1/2002; 347 (5): 360-361. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Bronchiolitis -- Chemically Induced
KW - Flavoring Agents -- Adverse Effects
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Adult
KW - Bronchiolitis -- Epidemiology
KW - Bronchiolitis -- Physiopathology
KW - Chi Square Test
KW - Chronic Disease
KW - Female
KW - Fisher's Exact Test
KW - Flavoring Agents -- Analysis
KW - Forced Expiratory Volume
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Pearson's Correlation Coefficient
KW - Prevalence
KW - Questionnaires
KW - Spirometry
KW - Surveys
KW - T-Tests
KW - Human
SP - 330
EP - 338
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 347
IS - 5
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, H2800, 1095 Willowdale Rd., Morgantown, WV 26505; kkreiss@cdc.gov
U2 - PMID: 12151470.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106964813
T1 - The Agency for Healthcare Research and Quality (AHRQ) responds to emerging threats of bioterrorism.
AU - Phillips S
AU - Dillard C
AU - Burstin H
Y1 - 2002/08//
N1 - Accession Number: 106964813. Language: English. Entry Date: 20021004. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 100901316.
KW - Bioterrorism
KW - Disaster Planning
KW - Health Services Research
KW - United States Agency for Healthcare Research and Quality -- United States
KW - Health Care Delivery
KW - Public Health
KW - United States Department of Health and Human Services -- United States
KW - United States
SP - 212
EP - 216
JO - Policy, Politics & Nursing Practice
JF - Policy, Politics & Nursing Practice
JA - POLICY POLIT NURS PRACT
VL - 3
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - The Agency for Healthcare Research and Quality (AHRQ) is a lead partner with the Department of Health and Human Services in addressing the issues of the health care system's preparedness in the event of a bioterrorist event. There is a critical need for the science of health services research and systems research to inform preparedness to achieve maximal system responsiveness and reinforce effective linkages between the health care system and the public health infrastructure. As AHRQ expands research in bioterrorism preparedness, nurse clinicians and nurse investigators are needed to bring the expertise to studies of the health care environments. There is an opportunity to address long-ignored systems and operations issues with collateral and shared benefits to the health care system. The bioterrorism preparedness research can reinvigorate our capacity to rebuild and restore a system responsive to future rare and catastrophic events as well as confront the current challenges of our systems of care.
SN - 1527-1544
AD - Senior Nurse Scholar, Center for Primary Care Research, Agency for Healthcare Research and Quality, US Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106983118
T1 - Overview of the ACCESS program...Access to Community Care and Effective Services and Supports
AU - Randolph F
AU - Blasinsky M
AU - Morrissey JP
AU - Rosenheck RA
AU - Cocozza J
AU - Goldman HH
Y1 - 2002/08//
N1 - Accession Number: 106983118. Corporate Author: ACCESS National Evaluation Team. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Community Mental Health Services -- Administration
KW - Health Services Accessibility
KW - Homeless Persons -- Psychosocial Factors
KW - Mental Disorders -- Therapy
KW - Community Mental Health Services -- Standards
KW - Health Care Delivery, Integrated
KW - United States
KW - Mental Disorders -- Psychosocial Factors
KW - Quality of Life
KW - Program Evaluation
SP - 945
EP - 948
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 53
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - The authors provide an overview of the ACCESS program (Access to Community Care and Effective Services and Supports), which evaluated the integration of service systems and its impact on outcomes for homeless persons with severe mental illness. The ACCESS program provided funds and technical assistance to nine community sites to implement strategies for system change that would promote systems integration. These experimental sites, along with nine comparison sites, also received funds to support outreach and assertive community treatment for 100 clients a year for four years at each site. Data on the implementation of system change strategies were collected from 1994 to 1998 during annual visits to the sites. Data on changes in systems integration were obtained from interviews with key informants from relevant organizations in each community. Client outcome data were obtained at program entry and three and 12 months later from 7,055 program participants across the four annual client cohorts at all sites. Detailed findings from the ACCESS evaluation are presented in two accompanying articles, and overall conclusions are offered in a fourth article.
SN - 1075-2730
AD - Acting Chief, Homeless Programs Branch, Center for Mental Health Services, 5600 Fishers Lane, Room 11C-05, Rockville, Maryland 20857; frandolp@samhsa.gov
U2 - PMID: 12161667.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106983118&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106983131
T1 - Lessons from the evaluation of the ACCESS program...Access to Community Care and Effective Services
AU - Goldman HH
AU - Morrissey JP
AU - Rosenheck RA
AU - Cocozza J
AU - Blasinsky M
AU - Randolph F
Y1 - 2002/08//
N1 - Accession Number: 106983131. Corporate Author: ACCESS National Evaluation Team. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Community Mental Health Services -- Administration
KW - Health Care Delivery, Integrated
KW - Health Services Accessibility
KW - Homeless Persons -- Psychosocial Factors
KW - Mental Disorders -- Therapy
KW - Health Policy
KW - Program Evaluation
KW - Organizational Culture
KW - United States
SP - 967
EP - 969
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 53
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - The authors summarize the main findings of the ACCESS (Access to Community Care and Effective Services) program and offer lessons for policy makers. Data from studies at the site level and the client level, which were presented in the two previous articles in this issue of Psychiatric Services, are summarized and synthesized with the authors' collective experience with the ACCESS program. The results of the evaluation suggest that although service systems integration can be improved, targeted efforts to implement strategies for integration do not produce better client outcomes. Efforts to integrate service systems can be supported by their effects on some organizational relationships within the mental health service system but not by their widespread effects across human services or their direct effects on clients.
SN - 1075-2730
AD - Department of Psychiatry and the Center for Mental Health Services Research, University of Maryland School of Medicine, 685 Baltimore Street, MSTF Building, Room 300, Baltimore, Maryland 21201; hh.goldman@verizon.net
U2 - PMID: 12161670.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106983131&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Al-Humadi, Nabil H.
AU - Lewis, Daniel M.
AU - Barger, Mark W.
AU - Siegel, Paul D.
AU - Ma, Joseph K. H.
AU - Ma, Jane Y. C.
T1 - Dose-dependent thiol and immune responses to ovalbumin challenge in Brown Norway rats.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2002/08//
VL - 18
IS - 7
M3 - Article
SP - 343
EP - 352
PB - Sage Publications, Ltd.
SN - 07482337
AB - Dose-dependent specific antibody production, antigen-dependent pulmonary inflammation, and thiol changes in the lung and associated lymph nodes were examined in a Brown Norway rat model of pulmonary sensitization. Cysteine (CYSH), glutathione (GSH), and markers of inflammation in bronchoalveolar lavage fluid (BALF) were measured following ovalbumin (OVA) inhalation challenge. Alveolar macrophages (AM) and pulmonary-associated lymph node cells (LNC) were isolated and intracellular CYSH and GSH assessed. OVA-specific IgE and IgG antibodies were quantified from sera. A dose-dependent biphasic response was noted with respect to OVA-specific IgE. OVA-specific IgG concentrations were maximal at 68 mg (OVA)/m[sup 3]. OVA challenge to sensitized rats induced increases in BALF albumin, total protein, lactate dehydrogenase, CYSH and GSH that were independent of serum antibody concentrations. AM thiols were modestly elevated at low OVA challenge doses, but sharply reduced at the higher OVA challenge doses. In contrast, both thiols were dose dependently elevated in BALF. CYSH, but not GSH, was elevated in LNC of OVA challenged rats. In summary, antigen exposure caused a dose-dependent alteration of inflammatory, thiol and immune parameters in OVA sensitized and challenged rats. Changes in thiol levels did not correlate with antibody responses. While the results of the present study do not support a functional role for thiols in the immune response, it is important to note the dose-dependent dramatic alteration seen in thiols following sensitization and challenge. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - PHYSIOLOGY
KW - Allergy treatment
KW - Thiols -- Therapeutic use
KW - Macrophages
KW - Immunoglobulins
KW - Lymph nodes
KW - ALVEOLAR MACROPHAGE
KW - IMMUNOGLOBULINS
KW - OVALBUMIN
KW - PARATHYMIC AND TRACHEAL LYMPH NODES
KW - THIOLS
N1 - Accession Number: 12376816; Al-Humadi, Nabil H. 1,2; Lewis, Daniel M. 1; Barger, Mark W. 1; Siegel, Paul D. 1; Email Address: pds3@cdc.gov; Ma, Joseph K. H. 2; Ma, Jane Y. C. 1; Affiliations: 1: HELD, National Institute for Occupational Safety and Health, ASB, L4218, 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Issue Info: 2002, Vol. 18 Issue 7, p343; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: PHYSIOLOGY; Subject Term: Allergy treatment; Subject Term: Thiols -- Therapeutic use; Subject Term: Macrophages; Subject Term: Immunoglobulins; Subject Term: Lymph nodes; Author-Supplied Keyword: ALVEOLAR MACROPHAGE; Author-Supplied Keyword: IMMUNOGLOBULINS; Author-Supplied Keyword: OVALBUMIN; Author-Supplied Keyword: PARATHYMIC AND TRACHEAL LYMPH NODES; Author-Supplied Keyword: THIOLS; Number of Pages: 10p; Illustrations: 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Seek Rhee, Gyu
AU - Hee Kim, So
AU - Sun Kim, Soon
AU - Hee Sohn, Kyung
AU - Jun Kwack, Seung
AU - Ho Kim, Byung
AU - Lea Park, Kui
T1 - Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2002/08//
VL - 16
IS - 4
M3 - Article
SP - 443
SN - 08872333
AB - Epoxidized soy bean oil (ESBO) and phthalate esters have been used as a plasticizer in polyvinyl chloride products. In this study, the embryotoxicity of ESBO and phthalate esters, namely, diethyl hexyl phthalate (DEHP), butylbenzyl phthalate (BBP) and dibutyl phthalate (DBP) was evaluated using short-term in vitro battery system, such as the whole embryo, midbrain and limb bud culture systems. Whole embryos at gestation day 9.5 were cultured for 48 h and the morphological scoring was measured. The cytotoxic effect and differentiation for mid-brain (MB) and limb bud (LB) cell were assessed by 50% inhibition concentration (IC50) with neutral red uptake and hematoxylin-stained foci (MB) or Alcian Blue staining (LB), respectively. In the whole embryo culture assay, ESBO (83, 250 and 750 μg/ml) exerted no toxic effect on growth and development of the embryo, whereas phthalate esters (1, 10, 100 μg/ml for DEHP, 10, 100, 1000 μg/ml for BBP and DBP) inhibited growth and development dose dependently. In mid-brain and limb bud culture, the IC50 of differentiation and cytotoxicity in BBP was 412.24 and 231. 76 μg/ml for mid-brain, and 40.13 and 182.38 μg/ml for limb bud, respectively. The IC50 of differentiation and cytotoxicity in DBP was 27.47 and 44.53 μg/ml for mid-brain, and 21.21 and 25.54 μg/ml for limb bud cells, respectively. The lower IC50 in both cells was obtained from DBP when compared to BBP. From these results, limb bud cells responded more sensitively to BBP and DBP than mid-brain cells. The IC50 of limb bud cell differentiation and cytotoxicity in DBP is 1.9 and 7.1 less than that of BBP. However, any alteration in cytotoxicity and differentiation was observed with ESBO treatment. These studies suggested that ESBO is not embryotoxic; however, DEHP, BBP and DBP exhibit embryotoxic potential at high concentration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Soybean
KW - Phthalate esters
KW - BBP
KW - butylbenzyl phthalate
KW - DBP
KW - DEHP
KW - dibutyl phthalate
KW - diethyl hexyl phthalate
KW - DPBS
KW - Dulbecco's phosphate buffered saline
KW - epoxidized soy bean oil
KW - ESBO
KW - LB
KW - limb bud
KW - MB
KW - mid-brain
N1 - Accession Number: 7837517; Seek Rhee, Gyu 1; Hee Kim, So 1; Sun Kim, Soon 1; Hee Sohn, Kyung 1; Jun Kwack, Seung 1; Ho Kim, Byung 1; Lea Park, Kui; Email Address: parkkl@kfda.go.kr; Affiliations: 1: Division of Reproductive and Developmental Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration,Seoul, 122-704,South Korea; Issue Info: Aug2002, Vol. 16 Issue 4, p443; Thesaurus Term: Soybean; Thesaurus Term: Phthalate esters; Author-Supplied Keyword: BBP; Author-Supplied Keyword: butylbenzyl phthalate; Author-Supplied Keyword: DBP; Author-Supplied Keyword: DEHP; Author-Supplied Keyword: dibutyl phthalate; Author-Supplied Keyword: diethyl hexyl phthalate; Author-Supplied Keyword: DPBS; Author-Supplied Keyword: Dulbecco's phosphate buffered saline; Author-Supplied Keyword: epoxidized soy bean oil; Author-Supplied Keyword: ESBO; Author-Supplied Keyword: LB; Author-Supplied Keyword: limb bud; Author-Supplied Keyword: MB; Author-Supplied Keyword: mid-brain; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 111110 Soybean Farming; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=7837517&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-18082-001
AN - 2002-18082-001
AU - Conviser, R.
AU - Pounds, M. B.
T1 - Background for the studies on ancillary services and primary care use.
T3 - Evaluating the contribution of ancillary services in improving access to primary care in the United States under the Ryan White CARE Act
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2002/08//
VL - 14
IS - Suppl,1
SP - S7
EP - S14
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Conviser, R., US Dept of Health & Human Services, Health Resources & Services Administration, HIV/AIDS Bureau, Office of Science & Epidmeiology, 5600 Fishers Lane, Room 7C-07, Rockville, MD, US, 20857
N1 - Accession Number: 2002-18082-001. Partial author list: First Author & Affiliation: Conviser, R.; US Dept of Health & Human Services, Health Resources & Services Administration, HIV/AIDS Bureau, Office of Science & Epidemiology, Rockville, MD, US. Release Date: 20020925. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Health Care Delivery; HIV. Classification: Community & Social Services (3373). Population: Human (10). Location: US. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2002.
AB - Provides background to the eight studies featured in this special supplement to AIDS Care. The eight studies examine retrospectively ancillary (support) services data collected after 1996 in six HIV epicenters, three smaller hard-hit cities and several states. These varied delivery settings serve racial and ethnic minority populations, men who have sex with men, injection drug users, women and mothers. The studies use a range of analytic approaches to understand whether receipt of certain enabling services correlated with early entry into and retention in care. Ancillary services (support services such as case management, housing, food, transportation, mental health and substance abuse treatment) are used by local HIV medical and community-based organizations in facilitative strategies directed to populations that have difficulty entering or staying in HIV primary care. Understanding the contribution of ancillary services to timely entry into and consistent use of primary care, including the expanding range of HIV therapeutics, is important to service delivery system planners and resource allocation decision-makers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ancillary services
KW - HIV primary care
KW - minority populations
KW - 2002
KW - Community Services
KW - Health Care Delivery
KW - HIV
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-18082-001&site=ehost-live&scope=site
UR - Rconviser@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-15775-001
AN - 2002-15775-001
AU - Dorfman, Sharon L.
AU - Smith, Shelagh A.
T1 - Preventive mental health and substance abuse programs and services in managed care.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2002/08//
VL - 29
IS - 3
SP - 233
EP - 258
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Smith, Shelagh A., Substance Abuse & Mental Health Services Administration, Ctr for Mental Health Services, Organization & Financing Office, 5600 Fishers Lane, Room 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2002-15775-001. PMID: 12216370 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Dorfman, Sharon L. Other Publishers: Springer. Release Date: 20020904. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse Prevention; Managed Care; Primary Mental Health Prevention. Classification: Health & Mental Health Services (3370). Methodology: Literature Review. References Available: Y. Page Count: 26. Issue Publication Date: Aug, 2002.
AB - Notes that if effective preventive behavioral health services were available to the millions of Americans enrolled in managed care organizations, the public health impact could be significant. This project sought to summarize published research-based information about effective preventive interventions for mental health and substance use (tobacco, alcohol, and other drugs) shown or likely to have no negative cost impact. Fifty-four studies satisfied seven screening criteria. Their findings demonstrated that preventive behavioral health interventions appropriate for managed care settings have been evaluated and have been shown to be effective. Some produced cost savings or offset costs. Six preventive behavioral health interventions are therefore recommended for managed care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention programs
KW - mental health programs
KW - substance abuse programs
KW - managed care services
KW - 2002
KW - Drug Abuse Prevention
KW - Managed Care
KW - Primary Mental Health Prevention
KW - 2002
DO - 10.1097/00075484-200208000-00001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-15775-001&site=ehost-live&scope=site
UR - ssmith@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-18742-004
AN - 2002-18742-004
AU - Carrington, Clark D.
AU - Bolger, Michael P.
T1 - An Exposure Assessment for Methylmercury from Seafood for Consumers in the United States.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2002/08//
VL - 22
IS - 4
SP - 689
EP - 699
CY - United Kingdom
PB - Blackwell Publishing
SN - 0272-4332
SN - 1539-6924
AD - Carrington, Clark D., Division of Risk Assessment, Office of Plants and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC, US, 20204
N1 - Accession Number: 2002-18742-004. PMID: 12224743 Partial author list: First Author & Affiliation: Carrington, Clark D.; Division of Risk Assessment, Office of Plants and Dairy Foods and Beverages, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Food Intake; Mercury (Metal); Toxicity. Classification: Consumer Psychology (3900). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug, 2002.
AB - An exposure model was developed to relate seafood consumption to levels of methylmercury in blood and hair in the U.S. population, and two subpopulations defined as children aged 2-5 and women aged 18-45. Seafood consumption was initially modeled using short-term U.S.-consumption surveys that recorded the amount of fish eaten per meal. Since longer exposure periods include more eaters with a lower daily mean intake, the consumption distribution was adjusted by broadening the distribution to include more eaters and reducing the distribution mean to keep total population intake constant. The distribution of mercury levels in other species was based on reported mean levels, with the frequency of consumption of each species based on market share. The shape distribution for the given mean was based on the range of variation encountered among shark, tuna, and swordfish. These distributions were integrated with a simulation that estimated average daily intake over a 360-day period, with 10,000 simulated individuals and 1,000 uncertainty iterations. These results were then compared to the recent National Health and Nutrition Examination Survey (NHANES) that tabulated blood and hair mercury levels in a cross-section of the U.S. population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methylmercury
KW - seafood consumption
KW - 2002
KW - Food Intake
KW - Mercury (Metal)
KW - Toxicity
KW - 2002
DO - 10.1111/0272-4332.00061
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-18742-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-15578-004
AN - 2002-15578-004
AU - Randolph, Frances
AU - Blasinsky, Margaret
AU - Morrissey, Joseph P.
AU - Rosenheck, Robert A.
AU - Cocozza, Joseph
AU - Goldman, Howard H.
T1 - Overview of the ACCESS program.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2002/08//
VL - 53
IS - 8
SP - 945
EP - 948
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2002-15578-004. PMID: 12161667 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Randolph, Frances; Ctr for Mental Health Services, Homeless Programs Branch, Rockville, MD, US. Institutional Authors: ACCESS National Evaluation Team. Release Date: 20020904. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Health Care Delivery; Homeless Mentally Ill; Integrated Services; Mental Health Services. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Methodology: Empirical Study. References Available: Y. Page Count: 4. Issue Publication Date: Aug, 2002.
AB - Provides an overview of the ACCESS program (Access to Community Care and Effective Services and Supports), which evaluated the integration of service systems and its impact on outcomes for homeless persons with severe mental illness. The ACCESS program provided funds and technical assistance to 9 community sites to implement strategies for system change that would promote systems integration. These experimental sites, along with 9 comparison sites, also received funds to support outreach and assertive community treatment for 100 clients a year for 4 yrs at each site. Data on the implementation of system change strategies were collected from 1994 to 1998 during annual visits to the sites. Data on changes in systems integration were obtained from interviews with key informants from relevant organizations in each community. Client outcome data were obtained at program entry and 3 and 12 mo later from 7,055 program participants across the 4 annual client cohorts at all sites. Detailed findings from the ACCESS evaluation are presented in 2 articles, (see records [rid]2002-15578-005[/rid] and [rid]2002-15578-006[/rid]) and overall conclusions are offered in a 4th (see record [rid]2002-15578-007[/rid]) article. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ACCESS program
KW - Access to Community Care and Effective Services and Supports
KW - service systems integration
KW - homeless persons
KW - severe mental illness
KW - 2002
KW - Community Services
KW - Health Care Delivery
KW - Homeless Mentally Ill
KW - Integrated Services
KW - Mental Health Services
KW - 2002
DO - 10.1176/appi.ps.53.8.945
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-15578-004&site=ehost-live&scope=site
UR - frandolp@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-04401-006
AN - 2002-04401-006
AU - Roberts, Charles
AU - MacNeill Horton, Arthur Jr.
T1 - Derived trail making test indices in a sample of sedative abusers: Demographic effects.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2002/08//
VL - 112
IS - 8
SP - 985
EP - 994
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - MacNeill Horton, Arthur Jr., Substance Abuse & Mental Health Admin, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2002-04401-006. PMID: 12448838 Partial author list: First Author & Affiliation: Roberts, Charles; Substance Abuse & Mental Health Admin, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20021002. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Demographic Characteristics; Drug Abuse; Sedatives. Minor Descriptor: Drug Rehabilitation. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Prospective Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 2002.
AB - Derived indices on the Trail Making test (TMT), a test often used to screen for cognitive impairment, were examined in a sample of 72 sedative abusers in drug abuse treatment programs. A mixed race sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the US. Data were analyzed to determine the effects of demographic variables on derived indices created by adding, subtracting, multiplying, and dividing parts A and B of the TMT in this large treatment sample of substance abusers. The variables of sex, age, ethnicity, and education were not statistically significant for selected derived indices of the TMT. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - derived indices
KW - drug abuse treatment programs
KW - cognitive impairment
KW - sedative abusers
KW - trail making
KW - demographic effects
KW - 2002
KW - Cognitive Ability
KW - Demographic Characteristics
KW - Drug Abuse
KW - Sedatives
KW - Drug Rehabilitation
KW - 2002
DO - 10.1080/00207450290025987
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-04401-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Parham, D.
AU - Conviser, R.
T1 - A brief history of the Ryan White CARE Act in the USA and its implications for other countries.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002/08/02/Aug2002 Supplement 1
VL - 14
M3 - Editorial
SP - S3
EP - S6
PB - Routledge
SN - 09540121
AB - Editorial. Presents a brief history of the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act, an act that provides funds to areas hit by HIV/AIDS epidemic in the U.S. Provisions of CARE act; CARE programs; Public AIDS care.
KW - MEDICAL laws & legislation
KW - AIDS (Disease)
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 7175425; Parham, D. 1; Conviser, R. 1; Source Information: Aug2002 Supplement 1, Vol. 14, pS3; Subject: MEDICAL laws & legislation; Subject: AIDS (Disease); Subject: PUBLIC health -- United States; Geographic Terms: UNITED States; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1080/09540120220149920
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=7175425&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106805825
T1 - Retinal repair risks.
AU - Woo E
Y1 - 2002/08/12/2002 Aug 12
N1 - Accession Number: 106805825. Language: English. Entry Date: 20030214. Revision Date: 20150711. Publication Type: Journal Article; brief item. Note: Published in multiple journals. Journal Subset: Nursing; USA. NLM UID: 9892046.
KW - Retina -- Surgery
KW - Nitrous Oxide -- Adverse Effects
KW - Postoperative Complications -- Prevention and Control
KW - Blindness
KW - Prostatectomy
KW - Surgical Patients
KW - Male
SP - 21
EP - 21
JO - Nursing Spectrum -- Illinois & Indiana Edition
JF - Nursing Spectrum -- Illinois & Indiana Edition
JA - NURS SPECTRUM (CHICAGO ILLINOIS INDIANA)
VL - 15
IS - 16
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106625207
T1 - Retinal repair risks.
AU - Woo E
Y1 - 2002/08/12/2002 Aug 12
N1 - Accession Number: 106625207. Language: English. Entry Date: 20050506. Revision Date: 20150711. Publication Type: Journal Article. Note: Published in multiple journals. Journal Subset: Nursing; USA. NLM UID: 9892044.
KW - Blindness
KW - Nitric Oxide -- Adverse Effects
KW - Postoperative Complications -- Prevention and Control
KW - Retina -- Surgery
KW - Male
KW - Prostatectomy
KW - Surgical Patients
SP - 2p
EP - 2p
JO - Nursing Spectrum -- New York & New Jersey Edition
JF - Nursing Spectrum -- New York & New Jersey Edition
JA - NURS SPECTRUM (NY NJ)
VL - 14A
IS - 16
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1081-3101
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106805650
T1 - Retinal repair risks.
AU - Woo E
Y1 - 2002/08/12/2002 Aug 12
N1 - Accession Number: 106805650. Language: English. Entry Date: 20030214. Revision Date: 20150711. Publication Type: Journal Article; brief item. Note: Published in multiple journals. Journal Subset: Nursing; USA. NLM UID: 9892045.
KW - Retina -- Surgery
KW - Nitrous Oxide -- Adverse Effects
KW - Postoperative Complications -- Prevention and Control
KW - Blindness
KW - Surgical Patients
KW - Prostatectomy
KW - Male
SP - 14
EP - 14
JO - Nursing Spectrum -- Philadelphia Tri -- State Edition
JF - Nursing Spectrum -- Philadelphia Tri -- State Edition
JA - NURS SPECTRUM (PHILADELPHIA TRI STATE)
VL - 11
IS - 16
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1074-858X
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 119411706
T1 - From the Food and Drug Administration.
AU - Crawford, Lester M Jr
Y1 - 2002/08/14/
N1 - Accession Number: 119411706. Language: English. Entry Date: 20030103. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Xenografts -- Standards
KW - Gastrointestinal Agents -- Therapeutic Use
KW - Drug Approval
KW - Pyridines -- Therapeutic Use
KW - Xenografts -- Legislation and Jurisprudence
KW - Practice Guidelines
KW - Animals
KW - Blood Transfusion -- Mortality
KW - Research Support
KW - United States Food and Drug Administration
KW - United States
KW - Financing, Organized
SP - 688
EP - 688
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 288
IS - 6
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of the Commissioner, US Food and Drug Administration, Rockville, MD 20857, USA
U2 - PMID: 12169049.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kang, Ju-Hee
AU - Jeong, Wonhyung
AU - Park, Younjoo
AU - Lee, Sung Yong
AU - Chung, Myeon Woo
AU - Lim, Hwa-Kyung
AU - Park, In-Sook
AU - Choi, Ki Hwan
AU - Chung, Soo Youn
AU - Kim, Dong Seop
AU - Park, Chang-Shin
AU - Hwang, Onyou
AU - Kim, Joo-il
T1 - Aroclor 1254-induced cytotoxicity in catecholaminergic CATH.a cells related to the inhibition of NO production
JO - Toxicology
JF - Toxicology
Y1 - 2002/08/15/
VL - 177
IS - 2/3
M3 - Article
SP - 157
SN - 0300483X
AB - The neuronal nitric oxide synthase (nNOS) specific inhibitor, 7-nitroindazole (7-NI), and the nitric oxide (NO) donor (S-nitroso-N-acetylpenicillarnine, SNAP) were used to study the role of NO in polychlorinated biphenyl (PCB: Aroclor 1254)-induced cytotoxicity in the immortalized dopaminergic cell line (CATH.a cells), derived from the central nervous system of mice. Treatment of the dopaminergic cells with various concentrations of Aroclor 1254 (0.5–10 μg/ml), a commercial PCB mixture, showed significant cytotoxicity as evaluated by lactate dehydrogenase (LDH) release and assessment of cell viability, depending on the concentration used. We also observed that Aroclor 1254 treatment reduced the level of nNOS expression. Furthermore, the cytotoxicity of Aroclor 1254 was augmented by 10 μM of 7-NI, which alone did not produce cytotoxicity, while it was protected by treatment with SNAP. Depending on the concentrations of Aroclor 1254 used, intracellular dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations were significantly decreased. Therefore, these results suggest that PCBs have the potential for dopaminergic neurotoxicity, which may be related with the PCBs-mediated alteration of NO production originating from nNOS at least in part. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitric oxide
KW - Polychlorinated biphenyls
KW - Antineoplastic agents
KW - Dopaminergic neurons
KW - CATH.a
KW - Dopamine
KW - Neurotoxicity
N1 - Accession Number: 7851205; Kang, Ju-Hee 1; Jeong, Wonhyung 1; Park, Younjoo 1; Lee, Sung Yong 1; Chung, Myeon Woo 1; Lim, Hwa-Kyung 1; Park, In-Sook 1; Choi, Ki Hwan 1; Chung, Soo Youn 1; Kim, Dong Seop 1; Park, Chang-Shin 2; Hwang, Onyou 3; Kim, Joo-il 1; Email Address: jikim@kfda.go.kr; Affiliations: 1: Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyung-Gu, Seoul 122-704, South Korea; 2: Department of Pharmacology, College of Medicine, Inha University, Inchon 402-751, South Korea; 3: Department of Biochemistry, University of Ulsan College of Medicine, Seoul, South Korea; Issue Info: Aug2002, Vol. 177 Issue 2/3, p157; Thesaurus Term: Nitric oxide; Thesaurus Term: Polychlorinated biphenyls; Subject Term: Antineoplastic agents; Subject Term: Dopaminergic neurons; Author-Supplied Keyword: CATH.a; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Neurotoxicity; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parshikov, Igor A.
AU - Moody, Joanna D.
AU - Heinze, Thomas M.
AU - Freeman, James P.
AU - Williams, Anna J.
AU - Sutherland, John B.
T1 - Transformation of cinoxacin by Beauveria bassiana
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002/08/27/
VL - 214
IS - 1
M3 - Article
SP - 133
SN - 03781097
AB - The ability of the fungus Beauveria bassiana ATCC 7159 to transform the antibacterial agent cinoxacin was investigated. Cultures in sucrose–peptone broth were dosed with cinoxacin, grown for 20 days, and then extracted with ethyl acetate. Two metabolites were detected and purified by high-performance liquid chromatography. The major metabolite was identified by mass and proton nuclear magnetic resonance spectra as 1-ethyl-1,4-dihydro-3-(hydroxymethyl)[1,3]dioxolo[4,5-g]cinnolin-4-one and the minor metabolite was identified as 1-ethyl-1,4-dihydro-6,7-dihydroxy-3-(hydroxymethyl)cinnolin-4-one. B. bassiana also reduced quinoline-3-carboxylic acid to 3-(hydroxymethyl)quinoline. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial transformation
KW - Cinoxacin
KW - Antibacterial agent
KW - Beauveria bassiana
KW - Biotransformation
N1 - Accession Number: 7865533; Parshikov, Igor A. 1; Moody, Joanna D. 1; Heinze, Thomas M. 1; Freeman, James P. 1; Williams, Anna J. 1; Sutherland, John B.; Email Address: jsutherland@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA; Issue Info: Aug2002, Vol. 214 Issue 1, p133; Subject Term: Bacterial transformation; Subject Term: Cinoxacin; Author-Supplied Keyword: Antibacterial agent; Author-Supplied Keyword: Beauveria bassiana; Author-Supplied Keyword: Biotransformation; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MA, J. Y. C.
AU - Yang, H.-M.
AU - Barger, M. W.
AU - Siegel, P. D.
AU - Zhong, B.-Z.
AU - Kriech, A. J.
AU - Castranova, V.
T1 - ALTERATION OF PULMONARY CYTOCHROME P-450 SYSTEM: EFFECTS OF ASPHALT FUME CONDENSATE EXPOSURE.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/08/30/
VL - 65
IS - 17
M3 - Article
SP - 1247
EP - 1260
SN - 15287394
AB - Exposure to asphalt fumes is a health concern due to the presence of polycyclic aromatic compounds (PACs) in asphalt. Bioactivation of many PACs requires metabolism by the cytochrome P-450 (P-450) system. The objective of this study was to evaluate the effects of exposure of rats to asphalt fume condensate (AFC), collected at the top of a paving asphalt storage tank, on the pulmonary microsomal P-450 system and to determine the genotoxic effects of such exposure. Male Sprague-Dawley rats were intratracheally instilled with saline or with 0.45, 2.22, or 8.88 mg/kg AFC for 3 consecutive days and sacrificed the following day. Lung microsomes were isolated by differential centrifugation of lung homogenates. Microsomal protein level, NADPH cytochrome c reductase activity, and the activities and protein levels of cytochrome P-450 isozymes CYP1A1 and CYP2B1 were monitored to assess the effects of AFC exposure on pulmonary P-450. The activities of CYP2B1 and CYP1A1 were determined by monitoring xenobiotic metabolism of 7-pentoxyresorufin and 7-ethoxyresorufin, respectively. CYP2B1 and CYP1A1 levels were determined by immunochemical analysis. Micronucleus (MN) formation in bone-marrow polychromatic erythrocytes (PCEs) was determined to assess the genotoxic effects of AFC exposure. The results showed that exposure of rats to AFC did not significantly affect total cytochrome P-450 content or cytochrome c reductase activity in the lung. CYP2B1 levels and enzyme activity were not significantly affected by AFC exposure. In contrast, CYP1A1 levels and activity were significantly increased in microsomes isolated from AFC-exposed lungs. Increased MN formation was observed only in high-dose AFC-exposed bone marrow PCEs. These results demonstrate that AFC exposure induced CYP1A1 activity and increased the enzyme levels of CYP1A1 in lung microsomes, suggesting that AFC exposure may alter metabolism of PACs by the cytochrome P-450 system in the lung. Alteration of cytochrome P-450 metabolism of PACs may contribute to the AFC-induced genotoxic effects demonstrated as MN formation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt
KW - Cytochrome P-450
N1 - Accession Number: 7008831; MA, J. Y. C. 1; Yang, H.-M. 1; Barger, M. W. 1; Siegel, P. D. 1; Zhong, B.-Z. 1; Kriech, A. J. 2; Castranova, V. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Heritage Research Group, Indianapolis, Indiana, USA; Issue Info: 2002, Vol. 65 Issue 17, p1247; Thesaurus Term: Asphalt; Thesaurus Term: Cytochrome P-450; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pizarro, Fernando
AU - Olivares, Manuel
AU - Hertrampf, Eva
AU - Mazariegos, Dora I.
AU - Arredondo, Miguel
AU - Letelier, Angélica
AU - Gidi, Virginia
T1 - Iron bis-glycine chelate competes for the nonheme-iron absorption pathway.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2002/09//
VL - 76
IS - 3
M3 - Article
SP - 577
EP - 581
SN - 00029165
AB - Background: The enterocytic absorption pathway of the food fortificant iron bis-glycine chelate has been the subject of controversy because it is not clear whether that substance uses the classic nonheme-iron absorption pathway or a pathway similar to that of heme absorption. Objective: The objective was to study the absorption pathway of iron bis-glycine chelate in human subjects. Design: Eighty-five healthy adult women were selected to participate in 1 of 6 iron-absorption studies. Study A involved the measurement of the dose-response curve of the absorption of ferrous sulfate (through a nonheme-iron absorption pathway); study B involved the competition of iron bis-glycine chelate with ferrous sulfate for the nonheme-iron absorption pathway; study C involved the measurement of the dose-response curve of hemeiron absorption; study D involved the competition of iron bisglycine chelate with hemoglobin for the heme-iron absorption pathway; and studies E and F were the same as studies A and B, except that the iron bis-glycine chelate was encapsulated in enteric gelatin capsules so that it would not be processed in the stomach. Results: Iron from the bis-glycine chelate competed with ferrous sulfate for the nonheme-iron absorption pathway. Iron from the bis-glycine chelate also competed with ferrous sulfate for absorption when liberated directly into the intestinal lumen. Iron from the bis-glycine chelate did not compete with heme iron for the heme-iron absorption pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - NUTRITION
KW - Absorption (Physiology)
KW - Intestinal absorption
KW - Nutrition research
KW - Iron in the body
KW - Bioavailability
KW - Iron -- Bioavailability
KW - Women
KW - ferrous bis-glycine
KW - iron absorption
KW - iron amino acid chelate
KW - Iron bioavailability
KW - iron fortification
KW - iron status
N1 - Accession Number: 94188854; Pizarro, Fernando 1; Olivares, Manuel 1; Hertrampf, Eva 1; Mazariegos, Dora I. 1; Arredondo, Miguel 1; Letelier, Angélica 1; Gidi, Virginia 2; Affiliations: 1: Institute of Nutrition and Food Technology, the University of Chile, Santiago; 2: US Department of Health and Human Services, Washington, DC; Issue Info: Sep2002, Vol. 76 Issue 3, p577; Thesaurus Term: RESEARCH; Thesaurus Term: NUTRITION; Subject Term: Absorption (Physiology); Subject Term: Intestinal absorption; Subject Term: Nutrition research; Subject Term: Iron in the body; Subject Term: Bioavailability; Subject Term: Iron -- Bioavailability; Subject Term: Women; Author-Supplied Keyword: ferrous bis-glycine; Author-Supplied Keyword: iron absorption; Author-Supplied Keyword: iron amino acid chelate; Author-Supplied Keyword: Iron bioavailability; Author-Supplied Keyword: iron fortification; Author-Supplied Keyword: iron status; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Trujillo, Michael H.
AU - Harris, Curtis
T1 - Indigenous Health: Fulfilling Our Obligation to Future Generations.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2002/09//
VL - 92
IS - 9
M3 - Editorial
SP - 1390
EP - 1390
PB - American Public Health Association
SN - 00900036
AB - The author reflects on issues related to the health of indigenous people. According to the author, indigenous people are demanding attention to the many pressing public health concerns that threaten their communities. He states that a global commitment to resources and program support is needed to effectively address the health problems faced by indigenous people.
KW - HEALTH
KW - Public health
KW - Indigenous peoples
KW - Ethnic groups
KW - Medical care
N1 - Accession Number: 7285749; Trujillo, Michael H. 1; Harris, Curtis 2; Affiliations: 1: Director, Indian Health Service; 2: Harlem Health Promotion Center, Columbia University; Issue Info: Sep2002, Vol. 92 Issue 9, p1390; Thesaurus Term: HEALTH; Thesaurus Term: Public health; Subject Term: Indigenous peoples; Subject Term: Ethnic groups; Subject Term: Medical care; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2/3p; Document Type: Editorial; Full Text Word Count: 572
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mendell, Mark J.
AU - Fisk, William J.
AU - Kreiss, Kathleen
AU - Levin, Hal
AU - Alexander, Darryl
AU - Cain, William S.
AU - Girman, John R.
AU - Hines, Cynthia J.
AU - Jensen, Paul A.
AU - Milton, Donald K.
AU - Rexroat, Larry P.
AU - Willingford, Kenneth M.
T1 - Improving the Health of Workers in Indoor Environments: Priority Research Needs for a National Occupational Research Agenda.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2002/09//
VL - 92
IS - 9
M3 - Article
SP - 1430
EP - 1440
PB - American Public Health Association
SN - 00900036
AB - Indoor nonindustrial work environments were designated a priority research area through the nationwide stakeholder process that created the National Occupational Research Agenda. A multidisciplinary research team used member consensus and quantitative estimates, with extensive external review, to develop a specific research agenda. The team outlined the following priority research topics: building-influenced communicable respiratory infections, building-related asthma/allergic diseases, and nonspecific building-related symptoms; indoor environmental science; and methods for increasing implementation of healthful building practices. Available data surest that improving building environments may result in health benefits for more than 15 million of the 89 million US indoor workers, with estimated economic benefits of $5 to $75 billion annually. Research on these topics, requiring new collaborations and resources, offers enormous potential health and economic returns. (Am J Public Health. 2002;92:1430-1440) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Occupational diseases
KW - Industrial hygiene
KW - Industrial safety
KW - Work-related injuries
KW - Work environment
KW - Accident prevention
N1 - Accession Number: 7285804; Mendell, Mark J. 1; Email Address: mjmendell@ibi.gov; Fisk, William J. 1; Kreiss, Kathleen 2; Levin, Hal 3; Alexander, Darryl 4; Cain, William S. 5; Girman, John R. 6; Hines, Cynthia J. 7; Jensen, Paul A. 2; Milton, Donald K. 8; Rexroat, Larry P. 9; Willingford, Kenneth M. 7; Affiliations: 1: Lawrence Berkeley National Laboratory, Berkeley, Calif.; 2: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies; 3: Building Ecology Research Group, San Diego, Calif.; 4: American Federation of Teachers, Washington, DC; 5: Department of Surgery, University of California San Diego, School of Medicine; 6: US Environmental Protection Agency, Indoor Environment Division Washington DC; 7: National Institute for Occupational Safety and Health, Division of Surveillace, Hazard Evaluations and Field Studies; 8: Department of Environmental Health, Harvard University School of Public Health, Boston, Mass.; 9: US General Services Administration, Public Building Service, Creater Southwest Region Fort Worth Tex.; Issue Info: Sep2002, Vol. 92 Issue 9, p1430; Thesaurus Term: RESEARCH; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Subject Term: Industrial safety; Subject Term: Work-related injuries; Subject Term: Work environment; Subject Term: Accident prevention; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 10125
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106863421
T1 - Public health matters. Improving the health of workers in indoor environments: priority research needs for a national occupational research agenda.
AU - Mendell MJ
AU - Fisk WJ
AU - Kreiss K
AU - Levin H
AU - Alexander D
AU - Cain WS
AU - Girman JR
AU - Hines CJ
AU - Jensen PA
AU - Milton DK
AU - Rexroat LP
AU - Wallingford KM
Y1 - 2002/09//
N1 - Accession Number: 106863421. Language: English. Entry Date: 20030905. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Occupational Health
KW - Work Environment
KW - Research Priorities
KW - Environmental Health
KW - Needs Assessment
KW - Occupational Exposure -- Prevention and Control
KW - Occupational Diseases -- Epidemiology
KW - Air Pollution, Indoor -- Adverse Effects
KW - National Institute for Occupational Safety and Health
KW - Research, Interdisciplinary
KW - Occupational Exposure -- Economics
KW - Morbidity
KW - Mortality
KW - Prevalence
KW - Costs and Cost Analysis
KW - Severity of Illness
KW - Descriptive Statistics
KW - Respiratory Tract Infections -- Epidemiology
KW - Asthma -- Epidemiology
KW - Sick Building Syndrome -- Epidemiology
KW - Communicable Diseases -- Epidemiology
KW - Passive Smoking
KW - Facility Design and Construction
KW - Occupational Diseases -- Prevention and Control
KW - Ventilation
KW - Human
SP - 1430
EP - 1440
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 92
IS - 9
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Indoor nonindustrial work environments were designated a priority research area through the nationwide stakeholder process that created the National Occupational Research Agenda. A multidisciplinary research team used member consensus and quantitative estimates, with extensive external review, to develop a specific research agenda. The team outlined the following priority research topics: building-influenced communicable respiratory infections, building-related asthma/allergic diseases, and nonspecific building-related symptoms; indoor environmental science; and methods for increasing implementation of healthful building practices. Available data suggest that improving building environments may result in health benefits for more than 15 million of the 89 million US indoor workers, with estimated economic benefits of $5 to $75 billion annually. Research on these topics, requiring new collaborations and resources, offers enormous potential health and economic returns.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio
U2 - PMID: 12197969.
DO - 10.2105/AJPH.92.9.1430
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106863454
T1 - Trends in diabetes prevalence among American Indian and Alaska Native children, adolescents, and young adults [corrected] [published erratum appears in AM J PUBLIC HEALTH 2002 Nov;92(11):1709].
AU - Acton KJ
AU - Burrows NR
AU - Moore K
AU - Querec L
AU - Geiss LS
AU - Engelgau MM
Y1 - 2002/09//
N1 - Accession Number: 106863454. Language: English. Entry Date: 20030905. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Native Americans
KW - Diabetes Mellitus, Type 2 -- Ethnology
KW - Diabetes Mellitus, Type 2 -- Trends
KW - Diabetes Mellitus, Type 2 -- Epidemiology -- United States
KW - Epidemiological Research
KW - Prevalence
KW - United States
KW - Health Services, Indigenous
KW - Outpatients
KW - Child
KW - Adolescence
KW - Adult
KW - International Classification of Diseases
KW - Sensitivity and Specificity
KW - Census
KW - Male
KW - Female
KW - Descriptive Statistics
KW - Sex Factors
KW - Trend Studies
KW - Human
SP - 1485
EP - 1490
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 92
IS - 9
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: This study determined trends in diabetes prevalence among young American Indians and Alaska Natives. METHODS: American Indian and Alaska Native children (< 15 years), adolescents (15-19 years), and young adults (20-34 years) with diabetes were identified from the Indian Health Service (IHS) outpatient database. The population living within IHS contract health service delivery areas was determined from census data. RESULTS: From 1990 to 1998, the total number of young American Indians and Alaska Natives with diagnosed diabetes increased by 71% (4534 to 7736); prevalence increased by 46% (6.4 per 1000 to 9.3 per 1000 population). Increases in prevalence were greater among adolescents and among young men. CONCLUSIONS: Diabetes should be considered a major public health problem among young American Indians and Alaska Natives.
SN - 0090-0036
AD - Indian Health Service, Rockville, Md
U2 - PMID: 12197981.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yoon, Sun-Ok
AU - Hirata, Rosario D. C.
AU - da Silva, Ana C. R.
AU - Nguyen, Nga Y.
AU - Hirata, Mario H.
T1 - Cloning and expression of soluble recombinant protein comprising the extracellular domain of the human type I interferon receptor 2c subunit (IFNAR-2c) in E. coli.
JO - Biotechnology Letters
JF - Biotechnology Letters
Y1 - 2002/09//
VL - 24
IS - 17
M3 - Article
SP - 1443
EP - 1448
SN - 01415492
AB - An optimized procedure was developed for production of the extracellular domain encoding amino acids 1–243 of the human type I interferon receptor 2c subunit (IFNAR-2c) as a fusion protein with glutathione S-transferase (GST-IFNAR2cEC) in E. coli to obtain active, soluble protein. Induction of protein expression at 37 °C resulted in a formation of inclusion body. Co-expression with bacterial chaperones, GroEL and GroES, failed to support the folding of GST-IFNAR2cEc under IPTG induction at 37 °C. Expression induced at 25 °C decreased the inclusion body formation up to 62% and cell disruption by a French press provided higher recovery of the recombinant protein than cell disruption by sonication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology Letters is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Recombinant proteins
KW - Antineoplastic agents
KW - Glutathione
KW - Chemical modification of proteins
KW - Molecular cloning
KW - Microorganisms -- Disintegration
KW - chaperones
KW - recombinant soluble protein
KW - type I interferon receptor 2c subunit
N1 - Accession Number: 15608268; Yoon, Sun-Ok 1; Hirata, Rosario D. C. 1; da Silva, Ana C. R. 2; Nguyen, Nga Y. 3; Hirata, Mario H. 1; Email Address: mhhirata@usp.br; Affiliations: 1: Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Science, Institute of Chemistry, University of São Paulo, S&altilde;o Paulo, SP 05508-900, Brazil.; 2: Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-900, Brazil.; 3: Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.; Issue Info: Sep2002, Vol. 24 Issue 17, p1443; Thesaurus Term: Escherichia coli; Subject Term: Recombinant proteins; Subject Term: Antineoplastic agents; Subject Term: Glutathione; Subject Term: Chemical modification of proteins; Subject Term: Molecular cloning; Subject Term: Microorganisms -- Disintegration; Author-Supplied Keyword: chaperones; Author-Supplied Keyword: recombinant soluble protein; Author-Supplied Keyword: type I interferon receptor 2c subunit; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Uhl, K.
AU - Kennedy, D.L.
AU - Kweder, S.L.
T1 - Risk Management Strategies in the Physicians' Desk Reference Product Labels for Pregnancy Category X Drugs.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/09//
VL - 25
IS - 12
M3 - Article
SP - 885
EP - 892
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Background: Drugs that carry a concern for teratogenicity are often classified as pregnancy category X in the drug label and contraindicated for use during pregnancy. Many drug labels can be found in the Physicians' Desk Reference (PDR), a widely used source of drug information by American clinicians and patients. Objective: To review product labelling in the electronic PDR for the pregnancy category X products for pregnancy prevention risk management components in labelling. Methods: The electronic version of the 2001 and 2002 PDR was searched for ‘pregnancy category X’ products using the full text search feature. All product labels identified were retrieved and reviewed for trade name, generic name, manufacturer and indication. Product labels were manually searched for any pregnancy prevention risk management strategies included in labelling. Those labels that had specific pregnancy prevention risk management strategies were further evaluated. Results: One hundred and seventeen pregnancy category X products were obtained from 2249 products searched in the 2001 PDR database and 124 pregnancy category X products were obtained from the 2150 products in the 2002 PDR database. All pregnancy category X products identified were drug products. The label/package insert for each drug was reviewed to identify risk management strategies for pregnancy prevention. The majority of the labels include as the sole risk management strategy either a black box warning and/or a contraindication for use in women who are or may become pregnant. Only 13 drugs contained specific pregnancy prevention risk management strategies in the label directing the clinician and/or patient, e.g. frequency of pregnancy testing, number and type of contraception methods. Two drugs, bexarotene capsules and gel, were only included in the 2001 PDR. Three drugs, isotretinoin, acitretin, and thalidomide, have formal pregnancy prevention risk management programmes. Conclusion: This study demonstrates the varied risk management approaches in labelling for pregnancy prevention for pregnancy category X drugs. There is a need for consistency in the classification of pregnancy category X products and the pregnancy prevention risk management strategies utilised in the labelling for them. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk management in business
KW - Labels -- Law & legislation
KW - Pregnancy
KW - Labelling
N1 - Accession Number: 7377845; Uhl, K. 1; Kennedy, D.L. 1; Kweder, S.L. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, Maryland, USA; Issue Info: Sep2002, Vol. 25 Issue 12, p885; Subject Term: Risk management in business; Subject Term: Labels -- Law & legislation; Subject Term: Pregnancy; Author-Supplied Keyword: Labelling; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kodell, Ralph L.
AU - Kang, Seung-Ho
AU - Chen, James J.
T1 - Statistical models of health risk due to microbial contamination of foods.
JO - Environmental & Ecological Statistics
JF - Environmental & Ecological Statistics
Y1 - 2002/09//
VL - 9
IS - 3
M3 - Article
SP - 259
EP - 271
PB - Springer Science & Business Media B.V.
SN - 13528505
AB - Between 6 million and 33 million cases of food-related illness are estimated to occur in the United States each year, with about 5000 episodes resulting in death. Growing concerns about the safety of food prompted the National Food Safety Initiative of 1997, the goal of which is to reduce the incidence of illness caused by food-borne pathogens. A key component of the food safety initiative is the improvement of farm-to-table risk assessment capabilities, including the development of improved dose-response models for estimating risk. When sufficient data are available, allowable contamination levels of specific micro-organisms in food are established using dose-response models to predict risk at very low doses based on experimental data at much higher doses. This necessitates having reliable models for setting allowable exposures to food-borne pathogens. While only limited data on relatively few micro-organisms that occur in food are available at present for dose-response modeling and risk estimation, still none of the two-parameter models proposed so far, including the popular Beta-Poisson (BP) model, appears to be completely satisfactory for describing and fitting all of the present data (Holcomb et al., 1999). The Weibull–Gamma (WG) model is the only three-parameter model that has been proposed to date. In this paper, new competitive three-parameter models are derived, using a formulation that can be parameterized to represent statistical variation with respect to the dose of micro-organism received by the host and the host’s susceptibility to infection. Parameters of the models are estimated using the maximum likelihood method. Experimental data on several common microbial contaminants in food are used to illustrate the methodology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Ecological Statistics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Safety
KW - Food
KW - Food handling
KW - Pathogenic microorganisms
KW - Diseases
KW - Statistics
KW - Risk management in business
KW - Quantitative research
KW - Estimates
KW - dose-response
KW - food safety initiative
KW - food-borne pathogen
KW - host susceptibility
KW - low-dose extrapolation
KW - risk assessment
N1 - Accession Number: 16866783; Kodell, Ralph L. 1; Kang, Seung-Ho 2; Chen, James J. 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, U.S.A.; 2: Department of Statistics, Ewha Womans University, 11-1, DaeHyun-Dong, SeoDaeMun-Gu, Seoul, Korea 120–750; Issue Info: Sep2002, Vol. 9 Issue 3, p259; Thesaurus Term: Safety; Thesaurus Term: Food; Thesaurus Term: Food handling; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Diseases; Subject Term: Statistics; Subject Term: Risk management in business; Subject Term: Quantitative research; Subject Term: Estimates; Author-Supplied Keyword: dose-response; Author-Supplied Keyword: food safety initiative; Author-Supplied Keyword: food-borne pathogen; Author-Supplied Keyword: host susceptibility; Author-Supplied Keyword: low-dose extrapolation; Author-Supplied Keyword: risk assessment; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Guor-Cheng Fang
AU - Cheng-Nan Chang
AU - Wu, Yuh-Shen
AU - Peter Pi-Cheng Fu
AU - Shyh-Chyi Chang
AU - I-Lin Yang
AU - Chang-Ju Yang
T1 - Characteristic study of particulates and metallic elements at an urban sampling site in Taichung, central Taiwan.
JO - International Journal of Environment & Pollution
JF - International Journal of Environment & Pollution
Y1 - 2002/09//
VL - 18
IS - 3
M3 - Article
SP - 1
EP - 1
SN - 09574352
AB - Focuses on characteristic study of particulates and metallic elements at an urban sampling site in Taichung, Taiwan. Statistics on suspended particulate concentrations at the urban sampling sites; Sources of emission of various elements at the sampling site.
KW - Metallic oxides
KW - Radioactive aerosols
KW - Taiwan
N1 - Accession Number: 10906321; Guor-Cheng Fang 1; Cheng-Nan Chang 2; Wu, Yuh-Shen 1; Peter Pi-Cheng Fu 3; Shyh-Chyi Chang 2; I-Lin Yang 2; Chang-Ju Yang 4; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang Institute of Technology, Sha-Lu, Taichung 433, Taiwan; 2: Department of Environmental Sciences, Tunghai University Taichung 407, Taiwan; 3: Division of Biochemical Toxicology National Center for Toxicological Research Jefferson, Arkansas 72079, USA; 4: Department of Computer Science and Information Engineering, Hungkuang Institute of Technology, Sha-Lu, Taichung 433, Taiwan.; Issue Info: 2002, Vol. 18 Issue 3, p1; Thesaurus Term: Metallic oxides; Thesaurus Term: Radioactive aerosols; Subject: Taiwan; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106813273
T1 - A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture.
AU - Hallman M
AU - Sennerby L
AU - Lundgren S
Y1 - 2002/09//Sep/Oct2002
N1 - Accession Number: 106813273. Language: English. Entry Date: 20030307. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Hjalmar Svensson Foundation, the Wielhelm and Martina Lundgren Foundation and Geistlich Pharmaceutical. NLM UID: 8611905.
KW - Dental Implants
KW - Biocompatible Materials -- Therapeutic Use
KW - Alveolar Process -- Surgery
KW - Maxilla -- Surgery
KW - Bone Transplantation -- Methods
KW - Wound Healing
KW - Maxillary Sinus -- Surgery
KW - Prostheses and Implants
KW - Male
KW - Female
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Titanium
KW - Autografts
KW - Allografts
KW - Cattle
KW - Outcomes Research
KW - Prospective Studies
KW - Patient Classification
KW - Evaluation Research
KW - Funding Source
KW - Human
SP - 635
EP - 643
JO - International Journal of Oral & Maxillofacial Implants
JF - International Journal of Oral & Maxillofacial Implants
JA - INT J ORAL MAXILLOFAC IMPLANTS
VL - 17
IS - 5
CY - Hanover Park, Illinois
PB - Quintessence Publishing Company Inc.
AB - PURPOSE: This study was designed to clinically and histologically evaluate the integration of titanium implants in different grafting materials used for maxillary sinus augmentation procedures. MATERIALS AND METHODS: A total of 21 patients and 36 maxillary sinuses were augmented with (1) autogenous particulated bone from the mandibular ramus, (2) bovine hydroxyapatite (BH) with membrane coverage, or (3) an 80/20 mixture of BH and autogenous bone. The grafts were allowed to heal for 6 to 9 months prior to placement of microimplants for histology and standard implants for prosthetic rehabilitation. After another 6 months of healing, when abutments were connected, the microimplants were retrieved for histologic and morphometric analyses. The outcome of the standard implants was clinically evaluated after 1 year of loading. RESULTS: The mean bone-implant contact was 34.6 +/- 9.5%, 54.3 +/- 33.1%, and 31.6 +/- 19.1% for autogenous bone, mixture of 20% autogenous bone/80% BH, and 100% BH, respectively. The corresponding values for the bone area parameter were 37.7 +/- 31.3%, 39.9 +/- 8%, and 41.7 +/- 26.6%. The BH area was found to be 12.3 +/- 8.5% and 11.8 +/- 3.6% for 20% autogenous bone/80% BH and 100% BH, respectively. There were no statistically significant differences for any parameter between any of the groups. After 1 year of loading, 6 of the 33 implants placed in autogenous bone grafts, 2 of the 35 implants placed in the BH/autogenous bone mixture, and 2 of 43 implants placed in BH were lost. There were no statistically significant differences between any of the groups. DISCUSSION: The histomorphometric analysis showed no differences between the 3 groups, indicating that autogenous bone graft can be substituted with bovine hydroxyapatite to 80% or 100% when used for maxillary sinus floor augmentation. The effect of adding autogenous bone remains unclear but may allow for a reduction of the healing time. CONCLUSION: The results from this clinical and histologic study indicate that similar short-term results can be expected when using autogenous bone, BH, or a mixture of them for maxillary sinus floor augmentation and delayed placement of dental implants.
SN - 0882-2786
AD - Clinic for Oral Maxillofacial Surgery, Public Health Service, Gavle Hospital, SE 80187 Gavie, Sweden, mats.hallman@lg.se
U2 - PMID: 12381063.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106798938
T1 - COPD vs. CHF: use history & physical exam clues to differentiate & treat two significant medical emergencies.
AU - Upchurch J
Y1 - 2002/09//2002 Sep
N1 - Accession Number: 106798938. Language: English. Entry Date: 20030124. Revision Date: 20150820. Publication Type: Journal Article; case study; CEU; exam questions; glossary; pictorial; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 8102138.
KW - Heart Failure -- Diagnosis
KW - Pulmonary Disease, Chronic Obstructive -- Diagnosis
KW - Prehospital Care
KW - Education, Continuing (Credit)
KW - Heart Failure -- Physiopathology
KW - Heart Failure -- Symptoms
KW - Heart Failure -- Drug Therapy
KW - Pulmonary Disease, Chronic Obstructive -- Physiopathology
KW - Pulmonary Disease, Chronic Obstructive -- Symptoms
KW - Pulmonary Disease, Chronic Obstructive -- Drug Therapy
KW - Hemodynamics
KW - Respiratory Circulation
KW - Patient Assessment
KW - Patient History Taking
KW - Physical Examination
KW - Diagnosis, Differential
KW - Oxygen Therapy
KW - Nitroglycerin -- Administration and Dosage
KW - Morphine -- Administration and Dosage
KW - Furosemide -- Administration and Dosage
KW - Bronchodilator Agents -- Therapeutic Use
KW - Ipratropium -- Therapeutic Use
KW - Female
KW - Aged
KW - Outpatients
SP - 82
EP - 91
JO - JEMS: Journal of Emergency Medical Services
JF - JEMS: Journal of Emergency Medical Services
JA - JEMS
VL - 27
IS - 9
CY - ,
PB - Elsevier Public Safety
SN - 0197-2510
AD - Indian Health Service, Crow Indian Reservation, Montana
U2 - PMID: 12209071.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105822665
T1 - Evaluation of highly bound drugs: interspecies, intersubject, and related comparisons.
AU - Collins JM
AU - Klecker RW Jr
Y1 - 2002/09//
N1 - Accession Number: 105822665. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Drugs -- Metabolism
KW - Animals
KW - Anticonvulsants -- Metabolism
KW - Blood Proteins -- Metabolism
KW - Dapsone -- Metabolism
KW - Dialysis
KW - Dogs
KW - Immunity
KW - Rats
KW - Valproic Acid -- Metabolism
KW - Animal Studies
SP - 971
EP - 975
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 42
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Free (unbound) drug is generally the pharmacologically relevant parameter for drug exposure. Thus, comparisons among species, among individuals, and in other situations such as cell culture or drug metabolism experiments in vitro should be based on free drug. Although the traditional focus has been on the absolute value for free drug, the applications for the data in this study are primarily comparative. Therefore, the authors evaluated direct dialysis of one plasma sample versus another. At equilibrium, the total concentration of valproate in human plasma was 3-fold higher than in rat plasma. The total concentration of monoacetyl dapsone was 10-fold higher in human plasma than in rat plasma and 18-fold higher in human plasma than in dog plasma. These results confirm predictions derived from conventional dialysis of each plasma sample separately versus buffer. These data can be interpreted directly, without interspecies correction factors for binding, especially for the most important cases--drugs that are highly protein-bound.
SN - 0091-2700
AD - Laboratory of Clinical Pharmacology, Food and Drug Administration, Rockville, Maryland 20857, USA.
U2 - PMID: 12211222.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chen, Frederick M.
AU - Hickner, John
AU - Fink, Kenneth S.
AU - Galliher, James M.
AU - Burstin, Helen
T1 - On the front lines: Family physicians' preparedness for bioterrorism.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2002/09//
VL - 51
IS - 9
M3 - Article
SP - 745
EP - 750
PB - Frontline Medical Communications
SN - 00943509
AB - OBJECTIVE The events of September 11, 2001, and the nation's recent experience with anthrax assaults made bioterrorism preparedness a national priority. Because primary care physicians are among the sentinel responders to bioterrorist attacks, we sought to determine family physicians beliefs about their preparedness for such an attack. STUDY DESIGN In October 2001 we conducted a national survey of 976 family physicians randomly selected from the American Academy of Family Physicians' active membership directory. POPULATION 614 (63%) family physicians responded to the survey. OUTCOMES MEASURED Physicians' self-reported ability to "know what to do as a doctor in the event of a suspected bioterrorist attack, recognize signs and symptoms of an illness due to bioterrorism, and know where to call to report a suspected bioterrorist attack." RESLUTS Ninety-five percent of physicians agreed that a bioterrorist attack is a real threat within the United States. However. only 27% of family physicians believed that the US health care system could respond effectively to a bioterrorist attack; fewer ( 17%) thought that their local medical communities could respond effectively. Twenty-six per-cent of physicians reported that they would know what to do as a doctor in the event of a bioterrorist attack. Only 18% had previous training in bioterrorism preparedness. In a multivariate analysis, physicians' reported that preparedness for a bioterrorist attack was significantly associated with previous bioterrorism preparedness training (OR 3.9 [95% CI 2.4-6.3]) and knowing how to obtain information in the event of a bioterrorist attack (OR 6.4 [95% CI 3.9-10.6]). CONCLUSIONS Only one quarter of family physicians felt prepared to respond to a bioterrorist event. However, training in bioterrorism preparedness as significantly associated with physicians' perceived ability to respond effectively to an attack. Primary care physician need more training in bioterrorism pre-paredness and easy access to public health and medical information in the event of a bioterrorist attack. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTERRORISM
KW - PHYSICIANS (General practice)
KW - PREPAREDNESS
KW - FAMILY medicine
KW - PRIMARY care (Medicine)
KW - Bioterrorism
KW - disease outbreaks
KW - disease outbreaks.
KW - primary care
KW - public health
N1 - Accession Number: 7466592; Chen, Frederick M. 1; Hickner, John 2; Email Address: John.Hickner@ht.msu.edu; Fink, Kenneth S. 1; Galliher, James M. 2; Burstin, Helen 1; Source Information: Sep2002, Vol. 51 Issue 9, p745; Subject: BIOTERRORISM; Subject: PHYSICIANS (General practice); Subject: PREPAREDNESS; Subject: FAMILY medicine; Subject: PRIMARY care (Medicine); Author-Supplied Keyword: Bioterrorism; Author-Supplied Keyword: disease outbreaks; Author-Supplied Keyword: disease outbreaks.; Author-Supplied Keyword: primary care; Author-Supplied Keyword: public health; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106710458
T1 - Disability services and college students with psychiatric disabilities.
AU - Megivern D
Y1 - 2002/09//
N1 - Accession Number: 106710458. Language: English. Entry Date: 20040312. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 101132991.
KW - Students, Disabled
KW - Student Health Services -- Utilization
KW - Mental Disorders
KW - Mental Health Services -- Utilization
KW - Students, College
KW - Female
KW - Male
KW - Adolescence
KW - Adult
KW - Semi-Structured Interview
KW - Interview Guides
KW - Descriptive Statistics
KW - Content Analysis
KW - Chi Square Test
KW - T-Tests
KW - Logistic Regression
KW - Academic Performance
KW - Odds Ratio
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Health Services Accessibility
KW - Human
SP - 25
EP - 41
JO - Journal of Social Work in Disability & Rehabilitation
JF - Journal of Social Work in Disability & Rehabilitation
JA - J SOC WORK DISABIL REHABIL
VL - 1
IS - 3
PB - Taylor & Francis Ltd
AB - Weiner (1999) has suggested that the process of accepting a disability and its associated limitations is often protracted for students with psychiatric disabilities, thus leaving many students unable to fully participate in services or in the design of academic accommodations. This research examines the relationship between psychiatric disability identity and use of academic accommodation services for 57 undergraduates with psychiatric impairments who are experiencing problems in their academic functioning. Willingness to utilize services was related to students' identification as having a psychiatric disability. Social work interventions are needed to support students in accepting psychiatric disabilities while concurrently crafting necessary accommodations.
SN - 1536-710X
AD - Center for Mental Health Services Research, Washington University, St Louis
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - LESER, MAUREEN S.
AU - YANOVSKI, SUSAN Z.
AU - YANOVSKI, JACK A.
T1 - A Low-Fat Intake and Greater Activity Level are Associated With Lower Weight Regain 3 Years After Completing a Very–Low-Calorie Diet
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2002/09//
VL - 102
IS - 9
M3 - Article
SP - 1252
EP - 1256
SN - 00028223
AB - Objective To examine the roles of diet, exercise, and lifestyle factors in determining long-term weight regain after weight loss with a very–low-calorie diet (VLCD).Subjects Twenty-seven of 38 women who lost weight with a VLCD.Design Graduates of a weight loss intervention study returned for follow-up 3 years after program completion. Percentage of initial weight loss that was regained was correlated with subjects’ fat intake (assessed via 7-day food records and a Diet Habit Survey), energy intake (assessed via 7-day food records), activity level and lifestyle factors (assessed via questionnaires) that are supportive of weight loss maintenance.Statistical analyses performed Regression analysis was used to assess the relationship of weight regain with fat intake, activity level, and energy intake. Contingency table analysis was used to assess the association between weight regain and lifestyle factors.Results Subjects followed experienced a -20.7 kg±9.2 kg (-19.2%±7%) (mean±standard deviation) weight change during the original VLCD program and a 13.9 kg±11.3 kg (76.6%±52.1%) weight change 3 years post-VLCD. Fat intake, assessed by a 7-day food diary, was positively correlated with weight regain at 3 years (r=0.66, P=.0004). Less weight regain was also seen with a lower percent fat intake as reflected by a higher Diet Habit Survey score (r=-0.55, P=.004). Women with the lowest tertile of reported fat intake (<25% of energy) from the Diet Habit Survey regained the least amount of weight (P=.05). Activity level was negatively correlated with weight regain (r=-0.53, P=.005). After correction for multiple comparisons, there was no association between total energy intake and weight regain. Lifestyle factors were also not associated with weight regain.Applications/conclusions Identifying strategies to maintain weight loss is crucial because of the negative health effects and increasing prevalence of obesity. For women who have lost weight on a VLCD, limiting dietary fat intake and maintaining physical activity are both important factors for the prevention of weight regain. To promote better weight loss outcomes, registered dietitians should help clients who have lost weight limit their fat intake to less than 30% of energy and encourage high activity levels. J Am Diet Assoc. 2002;102:1252–1256. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Dietetic Association is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Low-fat diet
KW - Exercise
KW - Lifestyles
KW - Weight loss
KW - Diet
N1 - Accession Number: 19668961; LESER, MAUREEN S. 1; YANOVSKI, SUSAN Z. 2; YANOVSKI, JACK A. 3; Affiliations: 1: M.S. Leser is a Clinical research dietitian with the National Institutes of Health Clinical Center Nutrition Department, Bethesda, Md, USA; 2: S.Z. Yanovski is Director of the Obesity and Eating Disorders Program, Division of Digestive Diseases and Nutrition, National Institute of Diabetes, Digestive Disease, and Kidney Disease, Bethesda, Md, USA; 3: J.A. Yanovski is Chief of the Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child and Human Development, Bethesda, Md, J. Yanovski and M. Leser are commissioned Officers in the US Public Health Service, USA; Issue Info: Sep2002, Vol. 102 Issue 9, p1252; Subject Term: Low-fat diet; Subject Term: Exercise; Subject Term: Lifestyles; Subject Term: Weight loss; Subject Term: Diet; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0002-8223(02)90277-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19668961&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106982643
T1 - Depressive symptoms and self-rated health in community-dwelling older adults: a longitudinal study.
AU - Han B
Y1 - 2002/09//
N1 - Accession Number: 106982643. Language: English. Entry Date: 20021129. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). NLM UID: 7503062.
KW - Depression -- In Old Age
KW - Health Status -- In Old Age
KW - Aged -- Psychosocial Factors
KW - Geriatric Assessment
KW - Prospective Studies
KW - Center for Epidemiological Studies Depression Scale
KW - Surveys
KW - Research Instruments
KW - Clinical Assessment Tools
KW - Odds Ratio
KW - Confidence Intervals
KW - Self Assessment -- In Old Age
KW - Community Living -- In Old Age
KW - Chi Square Test
KW - T-Tests
KW - Multivariate Analysis of Variance
KW - Repeated Measures
KW - Logistic Regression
KW - Symptoms -- In Old Age
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Human
SP - 1549
EP - 1556
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
VL - 50
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVES: To test whether baseline depressive symptoms in older adults increase the risk of subsequent decline in self-rated health and decrease the likelihood of subsequent improvement in self-rated health. DESIGN: A 2-year prospective cohort study. SETTING: Six thousand seven hundred fourteen community-dwelling older persons who completed the first and second wave of the Asset and Health Dynamics among the Oldest-Old Survey in the United States. PARTICIPANTS: Community-dwelling older people in the United States. MEASUREMENTS: Baseline depressive symptoms were measured using a short-form of the Center for Epidemiological Studies Depression Scale. Self-rated health was measured using a single item of global health rating. RESULTS: After adjustment for covariates, a high burden of depressive symptoms at baseline was predictive of greater decline in self-rated health (odds ratio (OR) for decline in those with high burden of depressive symptoms vs those without = 1.47, 95% confidence interval (CI) = 1.26-1.70). Likewise, high burden of depressive symptoms at baseline predicted less improvement in self-rated health (OR for improvement in those with high burden of depressive symptoms vs those without = 0.57, 95% CI = 0.50-0.65). CONCLUSIONS: Depressive symptomatology is an independent risk factor for subsequent changes in self-rated health in older adults. Thus, early prevention and intervention of depressive symptoms in community-dwelling older adults might be critical to promote and maintain their self-rated health.
SN - 0002-8614
AD - Bureau of Primary Health Care, Health Resources and Services Administration, U.S. Department of Health and Human Services, Bethesda, Maryland; bhan@hrsa.gov
U2 - PMID: 12383153.
DO - 10.1046/j.1532-5415.2002.50411.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106546793
T1 - Hand motor recovery after stroke: a transcranial magnetic stimulation mapping study of motor output areas and their relation to functional status.
AU - Bastings EP
AU - Greenberg JP
AU - Good DC
Y1 - 2002/09//
N1 - Accession Number: 106546793. Language: English. Entry Date: 20051202. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Frenchay Arm Test; Medical Research Council scale (MRC); Demeurisse Motricity Index. Grant Information: National Institutes of Health/National Institute of Child Health and Human Development (1P01HD35955-01A1). NLM UID: 100892086.
KW - Stroke -- Rehabilitation
KW - Frontal Lobe -- Physiopathology
KW - Functional Status
KW - Magnet Therapy
KW - Adult
KW - Aged
KW - Brain Mapping
KW - Stroke -- Physiopathology
KW - Clinical Assessment Tools
KW - Comparative Studies
KW - Convenience Sample
KW - Descriptive Statistics
KW - Dominance, Cerebral
KW - Evoked Potentials, Motor
KW - Female
KW - Functional Assessment
KW - Funding Source
KW - Hand
KW - Magnetic Resonance Imaging
KW - Male
KW - Mann-Whitney U Test
KW - Middle Age
KW - Motor Skills
KW - North Carolina
KW - Outcome Assessment
KW - P-Value
KW - Rehabilitation Centers
KW - Rehabilitation Patients
KW - Spearman's Rank Correlation Coefficient
KW - Stroke Patients
KW - Tomography, X-Ray Computed
KW - Treatment Outcomes
KW - Wilcoxon Rank Sum Test
KW - Human
SP - 275
EP - 282
JO - Neurorehabilitation & Neural Repair
JF - Neurorehabilitation & Neural Repair
JA - NEUROREHABIL NEURAL REPAIR
VL - 16
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - The respective contributions of the stroke and undamagedhemispheres to motor recovery after stroke remainscontroversial. The aim of this article is to evaluate therelationship between location and size of cortical motorareas and outcome after stroke. Twelve controls and 12stroke patients were studied. Hand cortical motor outputareas were determined using transcranial magneticstimulation. Motor-evoked potentials were recordedsimultaneously from both hands. Functional motor abilitieswere evaluated using well-validated measures.Surface area, weighted surface area, and center of gravityof motor output areas were calculated. Different pat-ternsof motor output areas to the paretic hand wereobserved; there was no motor output from the strokehemisphere in patients with poor outcome, contrasting tolarge motor output area in the stroke hemisphere inpatients with good outcome, regardless of infarct size orlocation. A significant correlation was found betweenmeasures of motor outcome in the stroke-affected upperextremity and both the surface area and weight of thecentral motor output area in the stroke hemisphere. Noipsilateral motor response was obtained after stimulationof either hemisphere. These data support an associationbetween preservation of cortical motor output area to theparetic hand in the stroke hemisphere and good motoroutcome.
SN - 1545-9683
AD - Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration
U2 - PMID: 12234089.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106966421
T1 - Device safety. Monitoring temporary pacemaker connections.
AU - Dwyer D
Y1 - 2002/09//
N1 - Accession Number: 106966421. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Pacemaker, Artificial
KW - Inventories
KW - Equipment Safety
KW - Electrodes, Implanted
KW - Equipment Design
SP - 76
EP - 76
JO - Nursing
JF - Nursing
JA - NURSING
VL - 32
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Utility Assessments of Opioid Treatment for Chronic Pain.
AU - Schmier, Jordana K.
AU - Palmer, Cynthia S.
AU - Flood, Emuella M.
AU - Gourlay, Geoffrey
JO - Pain Medicine
JF - Pain Medicine
Y1 - 2002/09//
VL - 3
IS - 3
SP - 218
EP - 230
SN - 15262375
N1 - Accession Number: 7532925; Author: Schmier, Jordana K.: 1 Author: Palmer, Cynthia S.: 2 Author: Flood, Emuella M.: 3 Author: Gourlay, Geoffrey: 4 ; Author Affiliation: 1 Exponent, Inc., Alexandria, Virginia;: 2 Agency for Healthcare Research and Quality, Rockville, Maryland;: 3 MEDTAP International Inc., Bethesda, Maryland; and: 4 Pain Management Unit, Flinders Medical Centre, South Australia; No. of Pages: 13; Language: English; Publication Type: Article; Update Code: 20021016
N2 - Abstract Objective. The primary study objective was to assess preferences for pain treatment outcomes among patients with cancer and noncancer chronic pain. A secondary objective was to assess their quality of life. Methods. Patients with cancer or noncancer chronic pain completed an interview using a computer to estimate utilities, or preference ratings, for health states related to pain treatment. The interview was devised using conjoint analysis methodology. Health states were characterized by four attributes (effectiveness of pain control, side effects, side effect severity, and opioid route of administration) and their levels, and each was assumed to last for a 14-day period. Participants also completed health-related quality of life and demographic questionnaires. Results. Mean preference ratings for participants with noncancer chronic pain (N = 96) ranged from a high of 0.87 (well-controlled pain with no side effects) to a low of 0.18 (poorly controlled pain with severe mood changes/alterations, severe respiratory depression, or severe vomiting). Mean preference ratings for participants with cancer pain (N = 25) were similar and ranged from a high of 0.89 (well-controlled pain with no side effects) to a low of 0.19 (poorly controlled pain with severe respiratory depression or severe vomiting). Results confirmed previous findings that chronic pain has a severe, multidimensional impact on patients, and that the quality of life of persons with chronic pain is among the lowest observed for any medical condition. Conclusions. This study provides a valuable assessment, from the patient's perspective, of the balance between treatment tolerability and manifestation of disease symptoms. Heightened awareness of patients' preferences for treatment outcomes may lead to improved selection of treatments, better adherence, and ultimate treatment success. ABSTRACT FROM AUTHOR
KW - *CHRONIC pain -- Treatment
KW - CANCER pain -- Treatment
KW - chronic cancer pain
KW - chronic noncancer pain
KW - Opioids
KW - Patient preference
KW - Quality of Life
KW - Utilities
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106793404
T1 - Principles of preventive care.
AU - Atkins D
Y1 - 2002/09//2002 Sep
N1 - Accession Number: 106793404. Language: English. Entry Date: 20030103. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - Preventive Health Care
KW - Medical Practice, Evidence-Based
SP - 475
EP - 486
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 29
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Growing interest in preventive care has contributed to a steady increase in the delivery of immunizations, common screening tests, and other preventive interventions. Clinicians today continue to face challenges in developing an office-based approach to prevention that is both evidence-based and practical. In this review, we explore how clinicians can find recommendations that are up-to-date and evidence-based, understand reasons for conflicting recommendations, and identify other issues that may affect the appropriateness of specific recommendations for one's practice. Copyright © 2002 by W.B. Saunders Company
SN - 0095-4543
AD - Agency for Health Care Research and Quality Center for Practice and Technology Assessment, 6010 Executive Blvd, Suite 300, Rockville, MD 20852; datkins@ahrq.gov
U2 - PMID: 12529891.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106793404&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106830342
T1 - Research and dissemination needs for ergonomics in agriculture.
AU - Estill CF
AU - Baron S
AU - Steege AL
Y1 - 2002/09//Sep/Oct2002
N1 - Accession Number: 106830342. Language: English. Entry Date: 20030509. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Agriculture
KW - Occupational-Related Injuries -- Prevention and Control
KW - Ergonomics
KW - Diffusion of Innovation
KW - Occupational Health
KW - Research Priorities
KW - Farmworkers
KW - Attitude to Health
KW - Cost Benefit Analysis
KW - National Institute for Occupational Safety and Health
KW - Risk Factors
KW - United States
KW - Musculoskeletal Diseases -- Prevention and Control
KW - Musculoskeletal Diseases -- Epidemiology
KW - Health Beliefs -- Ethnology
KW - Brainstorming
KW - Disease Surveillance
SP - 440
EP - 445
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 117
IS - 5
PB - Sage Publications Inc.
AB - In 1998, the National Institute for Occupational Safety and Health convened a conference of researchers interested in the ergonomics of agricultural workers. Participants included 20 representatives from universities, state governments, private agricultural and insurance companies, migrant worker organizations, agricultural industry organizations, and the Agricultural Extension Service. The attendees divided into three groups and brainstormed about research ideas and dissemination methods related to ergonomics for farm workers. The groups separately reported that interventions, cost-benefit analyses, and cultural belief systems were the main topics that needed to be researched to reduce physical risk factors for musculoskeletal disorders. The participants also presented ideas for disseminating information to farm owners and workers.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH; clf4@cdc.gov
U2 - PMID: 12500960.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Grubbs, Joseph W.
AD - US Department of Health and Human Services
T1 - Participation and Change: Using Large Group Intervention Methods to Inform Reflective Practice in a Community of Public Organizations
JO - Public Organization Review
JF - Public Organization Review
Y1 - 2002/09//
VL - 2
IS - 3
SP - 285
EP - 303
SN - 15667170
N1 - Accession Number: 0983615; Publication Type: Journal Article; Update Code: 200807
N2 - Public leaders face increasing pressure to build effective organizational communities. However, the purposive-rational foundation of knowledge in existing theory fails to inform the reflective practice necessary for this level of change. This article contrasts the prevailing viewpoint with the notion of changing organizations, an approach rooted in critical theory in which large group intervention methods are employed to foster participation and emancipatory change across organizational communities. The article features a case study involving a local government grant-making agency to show how participants engaged in reflective practice as a way of patterning community-wide change.
KW - Public Administration; Public Sector Accounting and Audits H83
L3 - http://link.springer.com/journal/volumesAndIssues/11115
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UR - http://link.springer.com/journal/volumesAndIssues/11115
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Loncek, Barry
AU - Banks, Steven
AU - Way, Bruce
AU - Bonaparte, Ernest
T1 - An empirical model of therapeutic process for psychiatric emergency room clients with dual disorders.
JO - Social Work Research
JF - Social Work Research
Y1 - 2002/09//
VL - 26
IS - 3
M3 - Article
SP - 132
PB - Oxford University Press / USA
SN - 10705309
AB - Many individuals with dual disorders of mental illness and substance abuse enter the mental health system through psychiatric emergency rooms (PERs), but may resist treatment and not follow through with referrals to services. This study examined the impact of therapeutic process on referral outcome. Raters used the Vanderbilt Psychotherapeutic Process Scales and Working Alliance inventory to evaluate audiotapes and transcripts of 39 PER sessions. Outcome was successful if clients attended all referral appointment. The authors found that therapist warmth and friendliness had a positive association with working alliance, which, in turn, was associated with successful referral Paradoxically, there was a negative relationship between warmth and friendliness and success. Analysis demonstrated that for a given level of warmth and friendliness, there must be u correspondingly higher level of working alliance to be associated with success. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Work Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - PSYCHOTHERAPIST & patient
KW - MENTALLY ill -- Care
KW - HOSPITAL emergency services
KW - PATIENT participation
KW - PSYCHIATRY
KW - MENTAL illness
KW - dual disorders
KW - mental illness psychiatric emergency rooms
KW - substance abuse
KW - therapeutic process.
N1 - Accession Number: 7460470; Loncek, Barry 1; Email Address: loneck@albany.edu; Banks, Steven 2; Way, Bruce 3; Bonaparte, Ernest 4; Source Information: Sep2002, Vol. 26 Issue 3, p132; Subject: MENTAL health; Subject: PSYCHOTHERAPIST & patient; Subject: MENTALLY ill -- Care; Subject: HOSPITAL emergency services; Subject: PATIENT participation; Subject: PSYCHIATRY; Subject: MENTAL illness; Author-Supplied Keyword: dual disorders; Author-Supplied Keyword: mental illness psychiatric emergency rooms; Author-Supplied Keyword: substance abuse; Author-Supplied Keyword: therapeutic process.; Number of Pages: 13p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Dugyala, Raviprakash R.
AU - Claggett, Thomas W.
AU - Kimmel, Gary L.
AU - Kimmel, Carole A.
T1 - HSP90α, HSP90β, and p53 Expression following in Vitro Hyperthermia Exposure in Gestation Day 10 Rat Embryos.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/09//
VL - 69
IS - 1
M3 - Article
SP - 183
EP - 190
PB - Oxford University Press / USA
SN - 10966080
AB - The studies presented here are aimed at understanding the expression of p53, HSP90α, and HSP90β in gestation day (GD) 10 CD rat embryos. GD 10 rat embryos were exposed in vitro to 37°C or 42°C for 15 min, then cultured at 37°C for 0.5, 1, 3, or 5 h. Immunohistochemistry was performed on formalin-fixed, paraffin embedded, sectioned embryos for p53, HSP90α, or HSP90β expression. p53 expression was minimal in control embryos but was induced with heat exposure. Maximum expression of p53 was observed in rostral tissues, e.g., the optic vesicle, rostral neuroepithelium, and mature (rostral) somites 3 and 5 h after heat exposure. Expression of p53 in the caudal region, such as in mid and caudal neuroepithelium, immature (caudal) somites, and presomitic mesoderm, was moderate compared to rostral areas. No p53 expression was observed in the heart under any condition. The rostral-caudal gradient of p53 expression was not observed for HSP90α expression. HSP90α was induced in heat-exposed embryos beginning at 1 h, predominantly in neural tube and optic vesicle. Moderate but increased expression was observed in the somites of heat-exposed embryos at 3 and 5 h. Expression of p53 was primarily nuclear while HSP90α expression was mostly cytoplasmic. No clear association was observed between heat-induced HSP90α and p53 expression. HSP90β was expressed extensively in control and heat-exposed embryos. Results indicate that heat induces p53 and HSP90α expression, but not HSP90β expression, and that HSP90α induction is not likely to be involved in p53 regulation in mammalian embryos. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Embryology
KW - Mammals
KW - Rats as laboratory animals
KW - Immunohistochemistry
KW - Mesoderm
KW - developmental toxicity
KW - HSP90
KW - hyperthermia
KW - p53
KW - rat embryo culture
N1 - Accession Number: 44406383; Dugyala, Raviprakash R. 1; Claggett, Thomas W. 1; Kimmel, Gary L. 2,3; Kimmel, Carole A. 2,3; Email Address: kimmel.carole@epa.gov; Affiliations: 1: Pathology Associates, a Charles River Company, Frederick, Maryland 21701; 2: National Center for Environmental Assessment, Office of Research and Development, U. S. Environmental Protection Agency, Washington, D.C. 20460; 3: Health Sciences Branch, Life Sciences Division, Office of Science and Technology, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland 20857; Issue Info: Sep2002, Vol. 69 Issue 1, p183; Thesaurus Term: Embryology; Thesaurus Term: Mammals; Subject Term: Rats as laboratory animals; Subject Term: Immunohistochemistry; Subject Term: Mesoderm; Author-Supplied Keyword: developmental toxicity; Author-Supplied Keyword: HSP90; Author-Supplied Keyword: hyperthermia; Author-Supplied Keyword: p53; Author-Supplied Keyword: rat embryo culture; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 5 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106809099
T1 - NAT screening of blood and plasma donations: evolution of technology and regulatory policy.
AU - Tabor E
AU - Epstein JS
Y1 - 2002/09//
N1 - Accession Number: 106809099. Language: English. Entry Date: 20030221. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Nucleic Acid Amplification Techniques
KW - Blood Transfusion
KW - Health Screening -- Methods
KW - Hepatitis -- Prevention and Control
KW - HIV Infections -- Prevention and Control
KW - Blood Donors
KW - Blood Transfusion -- Adverse Effects
KW - Hepatitis -- Transmission
KW - Parvovirus Infections -- Transmission
KW - Parvovirus Infections -- Prevention and Control
SP - 1230
EP - 1237
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 42
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Office of Blood Research and Review, HFM-300, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448; tabor@cber.fda.gov
U2 - PMID: 12430684.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tabor, Edward
AU - Epstein, Jay S.
T1 - NAT screening of blood and plasma donations: evolution of technology and regulatory policy.
JO - Transfusion
JF - Transfusion
Y1 - 2002/09//
VL - 42
IS - 9
M3 - Article
SP - 1230
EP - 1237
SN - 00411132
AB - Discusses the implementation of NAT screening of blood plasma and plasma donations in the United States by the US Food and Drug Administration. NAT screening for hepatitis C virus; HIV-1 screening; Detection of parvovirus B19 an hepatitis A virus in whole blood donations; Residual risk for HCV, HIV-1, HBV after screening blood or plasma; Donor screening versus in-process control testing.
KW - BLOOD plasma
KW - HEPATITIS C virus
KW - CLINICAL chemistry
KW - UNITED States
N1 - Accession Number: 10785618; Tabor, Edward 1; Epstein, Jay S. 1; Source Information: Sep2002, Vol. 42 Issue 9, p1230; Subject: BLOOD plasma; Subject: HEPATITIS C virus; Subject: CLINICAL chemistry; Geographic Terms: UNITED States; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 2004-17118-001
AN - 2004-17118-001
AU - Snowden, Lonnie R.
AU - Pingitore, David
T1 - Frequency and Scope of Mental Health Service Delivery to African Americans in Primary Care.
JF - Mental Health Services Research
JO - Mental Health Services Research
JA - Ment Health Serv Res
Y1 - 2002/09//
VL - 4
IS - 3
SP - 123
EP - 130
CY - Germany
PB - Springer
SN - 1522-3434
SN - 1573-6636
AD - Snowden, Lonnie R., Center for Mental Health Services Research, University of California, 2020 Milvia Street, Suite 405, Berkeley, CA, US, 94720
N1 - Accession Number: 2004-17118-001. PMID: 12385565 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, University of California, Berkeley, CA, US. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blacks; Health Care Delivery; Mental Health Services; Primary Health Care; Racial and Ethnic Differences. Minor Descriptor: Health Service Needs; Quality of Care. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2002.
AB - This study examines whether African Americans with mental health complaints visit primary care physicians more than psychiatrists, and whether they demonstrate this preference more than do Whites. It addresses also whether when presenting with mental health concerns, African Americans and Whites receive a comparable range of interventions, including psychotropic medications. National estimates using the National Ambulatory Medical Care Surveys conducted in 1995 and 1996 confirmed the first hypothesis: African American did make more mental health-related office visits to primary care physicians than did psychiatrists and they did so more than Whites. Mental health interventions on behalf of African Americans and Whites proved to be similar, except that African Americans were less likely to be provided a psychotropic medication. Because African Americans are especially likely to receive outpatient mental health services from primary care physicians, the lower quality of mental health care occurring in primary care disproportionately affects African Americans. Fewer African American visits resulted in prescribing psychotropic medications, and this corroborated findings by other researchers. More research is needed to understand this disparity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health service delivery
KW - African Americans
KW - primary care
KW - ethnic differences
KW - outpatient care
KW - quality of mental health care
KW - 2002
KW - Blacks
KW - Health Care Delivery
KW - Mental Health Services
KW - Primary Health Care
KW - Racial and Ethnic Differences
KW - Health Service Needs
KW - Quality of Care
KW - 2002
DO - 10.1023/A:1019709728333
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17118-001&site=ehost-live&scope=site
UR - snowden@uclink4.berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17118-003
AN - 2004-17118-003
AU - Pingitore, David P.
AU - Scheffler, Richard M.
AU - Schwalm, Douglas
AU - Zarin, Deborah A.
AU - West, Joyce C.
T1 - Variation in Routine Psychiatric Workload: The Role of Financing Source, Managed Care Participation, and Mental Health Workforce Competition.
JF - Mental Health Services Research
JO - Mental Health Services Research
JA - Ment Health Serv Res
Y1 - 2002/09//
VL - 4
IS - 3
SP - 141
EP - 150
CY - Germany
PB - Springer
SN - 1522-3434
SN - 1573-6636
AD - Pingitore, David P., Center for Mental Health Services Research, 2020 Milvia Street, Berkeley, CA, US, 94720
N1 - Accession Number: 2004-17118-003. PMID: 12385567 Partial author list: First Author & Affiliation: Pingitore, David P.; Center for Mental Health Services Research, University of California, Berkeley, CA, US. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Managed Care; Mental Health Services; Psychiatrists; Work Load. Minor Descriptor: Mental Health Personnel Supply. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2002.
AB - This study was conducted to examine the association between psychiatrists' demographic characteristics, payment source, and managed care participation and psychiatrists' practice workload, and between the supply of other mental health providers in a psychiatrist's county of practice and psychiatrists' practice workload. Data from the 1996 American Psychiatric Association National Survey of Psychiatric Practice were merged with national countywide measures of mental health workforce and environmental data from the 1996 Area Resource File. In comparison to male psychiatrists, female psychiatrists treat fewer patients per week, provide less total hours of weekly patient care, and obtain fewer new monthly referrals. An increase in psychiatrists' managed care participation was associated with only minor increases in the number of patients per week, weekly time spent in clinical care, and number of new monthly referrals. The supply of other mental health providers was not associated with variation in practice workload. Once psychiatrists participate in managed care plans, an increase in their participation rate does not significantly expand clinical practice workload. The supply of other mental health providers was not significantly associated with variation in psychiatrists' workload, which suggests that substitution effects may not be evident with this aspect of psychiatric practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric workload
KW - financing source
KW - managed care participation
KW - mental health workforce competition
KW - psychiatrists
KW - demographic characteristics
KW - 2002
KW - Demographic Characteristics
KW - Managed Care
KW - Mental Health Services
KW - Psychiatrists
KW - Work Load
KW - Mental Health Personnel Supply
KW - 2002
DO - 10.1023/A:1019759029241
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17118-003&site=ehost-live&scope=site
UR - dpingitore@igc.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-06893-007
AN - 2002-06893-007
AU - Huie, Stephanie A. Bond
AU - Hummer, Robert A.
AU - Rogers, Richard G.
T1 - Individual and contextual risks of death among race and ethnic groups in the United States.
JF - Journal of Health and Social Behavior
JO - Journal of Health and Social Behavior
JA - J Health Soc Behav
Y1 - 2002/09//
VL - 43
IS - 3
SP - 359
EP - 381
CY - US
PB - American Sociological Assn
SN - 0022-1465
SN - 2150-6000
AD - Huie, Stephanie A. Bond, Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, 2101 East Jefferson Street, Suite 500, Rockville, MD, US, 20852
N1 - Accession Number: 2002-06893-007. Other Journal Title: Journal of Health & Human Behavior. Partial author list: First Author & Affiliation: Huie, Stephanie A. Bond; Agency for Healthcare Research & Quality, Ctr for Cost & Financing Studies, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20030108. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Contextual Associations; Death and Dying; Individual Differences; Psychosocial Factors; Racial and Ethnic Differences. Minor Descriptor: Blacks; Mortality Rate; Neighborhoods; Whites; Latinos/Latinas. Classification: Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 23. Issue Publication Date: Sep, 2002.
AB - An emerging area of social science research focuses on individual-level and contextual-level determinants of Black-White adult mortality differentials in the US. However, no research on adult mortality differentials has distinguished multiple Hispanic subgroups and explored the role of nativity at both the individual and contextual levels for small geographic areas. Using the 1986-1997 National Health Interview Survey-National Death Index linked file, the authors examined the effects of individual and contextual factors on Black-White and multiple Hispanic subgroup (Mexican Americans, Puerto Ricans, and 'other' Hispanic) differentials in adult mortality (adults aged 18-64 yrs). In addition, they used a new, innovative geographic area--the very small area--as their contextual unit of analysis. They found that excess mortality risks for all race-ethnic groups considered are associated with not only individual characteristics, but also neighborhood characteristics. In addition, percent foreign born in a neighborhood is protective of Hispanic subgroup mortality for Puerto Rican, Mexican American, and 'other' Hispanic adults in the 45-64 age category. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adult mortality
KW - individual risks
KW - contextual risks
KW - death & dying
KW - racial & ethnic differences
KW - psychosocial factors
KW - neighborhood characteristics
KW - Blacks vs Whites vs Hispanics
KW - US
KW - 2002
KW - Contextual Associations
KW - Death and Dying
KW - Individual Differences
KW - Psychosocial Factors
KW - Racial and Ethnic Differences
KW - Blacks
KW - Mortality Rate
KW - Neighborhoods
KW - Whites
KW - Latinos/Latinas
KW - 2002
DO - 10.2307/3090209
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-06893-007&site=ehost-live&scope=site
UR - shuie@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-18300-002
AN - 2002-18300-002
AU - Hennessy, Kevin D.
AU - Green-Hennessy, Sharon
AU - Buck, Jeffrey A.
AU - Miller, Kay
T1 - Use of psychotropic drugs by mentally ill Medicaid beneficiaries.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2002/09//
VL - 53
IS - 9
SP - 1070
EP - 1070
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Hennessy, Kevin D.
N1 - Accession Number: 2002-18300-002. PMID: 12221302 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Hennessy, Kevin D.; US Dept of Health & Human Services, Washington, DC, US. Release Date: 20021016. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Drug Therapy; Medicaid; Neuroleptic Drugs; Schizophrenia. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. Page Count: 1. Issue Publication Date: Sep, 2002.
AB - Presents data on the use of psychotropic drugs by persons diagnosed with schizophrenia or an affective disorder and enrolled in Medicaid programs in 1995 in 1 of 10 US states. The authors used data from the State Medicaid Research Files of the Center for Medicare and Medicaid Services. The analysis only included adults aged 21-64 yrs. Across 10 states, a total of 185,791 Medicaid enrollees used some type of mental health or substance abuse treatment service. Antipsychotics were used by 84% of those with schizophrenia, while 70% of those with an affective disorder used an antidepressant. The authors state that future research could productively examine prescribing patterns and use of psychotropic drugs by individuals with specific mental disorders and how such use is related to the desired outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotropic drugs
KW - schizophrenia
KW - affective disorder
KW - Medicaid
KW - 2002
KW - Affective Disorders
KW - Drug Therapy
KW - Medicaid
KW - Neuroleptic Drugs
KW - Schizophrenia
KW - 2002
DO - 10.1176/appi.ps.53.9.1070
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-18300-002&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3484-2663
UR -
UR - kevin.hennessy@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-18917-004
AN - 2002-18917-004
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Derived Trail Making Test indices in a sample of narcotic/other opiate abusers: Demographic effects.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2002/09//
VL - 112
IS - 9
SP - 1075
EP - 1084
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2002-18917-004. PMID: 12487096 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20021023. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Demographic Characteristics; Drug Abuse; Neuropsychological Assessment. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2002.
AB - Derived indices on the Trail Making Test (TMT), a test often used to screen for cognitive impairment, were examined in a sample of 191 narcotic/other opiate abusers (mean age 32.6 yrs) in drug abuse treatment programs. A mixed race sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the US. Data were analyzed to determine the effects of demographic variables on derived indices created by adding, subtracting, multiplying, and dividing parts A and B of the TMT in this large treatment sample of substance abusers. The variables of age, ethnicity, and education were statistically significant for the total score (A + B) and interaction score (A×B/100) derived indices of the TMT. In addition, the difference score (B - A) was statistically significant for education. The ratio score (B/A) was not significant for any demographic variable. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Trail Making Test
KW - narcotic & opiate abusers
KW - drug abuse treatment programs
KW - derived indices
KW - demographic effects
KW - cognitive impairment
KW - 2002
KW - Cognitive Ability
KW - Demographic Characteristics
KW - Drug Abuse
KW - Neuropsychological Assessment
KW - 2002
DO - 10.1080/00207450290026067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-18917-004&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-18548-005
AN - 2002-18548-005
AU - Han, Beth
T1 - Depressive symptoms and self-rated health in community-dwelling older adults: A longitudinal study.
JF - Journal of the American Geriatrics Society
JO - Journal of the American Geriatrics Society
JA - J Am Geriatr Soc
Y1 - 2002/09//
VL - 50
IS - 9
SP - 1549
EP - 1556
CY - United Kingdom
PB - Blackwell Publishing
SN - 0002-8614
SN - 1532-5415
AD - Han, Beth, #215 4949 Battery Lane, Bethesda, MD, US, 20814
N1 - Accession Number: 2002-18548-005. PMID: 12383153 Partial author list: First Author & Affiliation: Han, Beth; US Dept of Health & Human Services, Health Resources & Services Administration, Bureau of Primary Health Care, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20030414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Ability Level; Health; Major Depression; Symptoms. Minor Descriptor: Demographic Characteristics; Geriatrics; Physical Disorders. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2002.
AB - Examined the relationship between baseline depressive symptoms and subsequent changes in self-rated health of elderly individuals during a 2-yr period. 6,714 community-dwelling individuals (aged 65-85+ yrs) completed surveys regarding self-rated health, functional disability, depression, and sociodemographic variables at baseline and at 2-yr follow-up. Results show that a high burden of depressive symptoms at baseline was predictive of greater decline in self-rated health. Activities of daily living, instrumental activities of daily living impairments, functional disability, and medical conditions deteriorated significantly. High depressive symptoms at baseline predicted less improvement in self-rated health. It is concluded that depressive symptomatology is an independent risk factor for subsequent changes in self-rated health in older adults. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - symptoms
KW - self-rated health
KW - elderly
KW - functional disability
KW - sociodemographic characteristics
KW - medical conditions
KW - 2002
KW - Ability Level
KW - Health
KW - Major Depression
KW - Symptoms
KW - Demographic Characteristics
KW - Geriatrics
KW - Physical Disorders
KW - 2002
DO - 10.1046/j.1532-5415.2002.50411.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-18548-005&site=ehost-live&scope=site
UR - bhan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106825995
T1 - Sentinel human health indicators: to evaluate the health status of vulnerable communities.
AU - Hicks HE
AU - De Rosa CT
Y1 - 2002/09/02/2002 Sep-Oct Suppl 1
N1 - Accession Number: 106825995. Language: English. Entry Date: 20030425. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2002 Sep-Oct Suppl 1. Journal Subset: Biomedical; Canada; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health. NLM UID: 0372714.
KW - Health Status Indicators
KW - Community Assessment -- Great Lakes Region
KW - Water Pollution -- Adverse Effects -- Great Lakes Region
KW - Water Pollution -- Legislation and Jurisprudence -- United States
KW - Environmental Exposure -- Great Lakes Region
KW - Environmental Monitoring -- Great Lakes Region
KW - Great Lakes Region
KW - United States
KW - Canada
KW - Environmental Pollutants
KW - Registries, Disease
KW - Food Contamination
KW - Research Priorities
KW - Risk Factors
KW - Hazardous Materials
KW - Prenatal Exposure Delayed Effects
KW - Infant, Newborn
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Aged, 80 and Over
KW - Male
KW - Female
KW - Fetus
SP - S57
EP - 61
JO - Canadian Journal of Public Health
JF - Canadian Journal of Public Health
JA - CAN J PUBLIC HEALTH
VL - 93
IS - S1
CY - Ottawa, Ontario
PB - Canadian Public Health Association
AB - The presence of toxic substances in the Great Lakes (GL) basin continues to be a significant concern. In the United States, some 70,000 commercial and industrial compounds are now in use. More than 30,000 are produced or used in the Great Lakes ecosystem. These substances include organochlorines (e.g., polychlorinated biphenyls (PCBs), dioxins, furans, dieldrin, etc.), heavy metals such as methylmercury, and alkylated lead, and polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene). The IJC has identified 42 locations in the GL basin of the United States and Canada as Areas of Concern (AOCs) because of high concentrations of these toxic substances. In 1990 the U.S. Congress amended the Great Lakes Critical Programs Act to create The Agency for Toxic Substances and Disease Registry (ATSDR) Great Lakes Human Health Effects Research Program (GLHHERP) to begin to address these issues. This program characterizes exposures to contaminants via consumption of GL fish and investigates the potential for short- and long-term adverse health effects. This paper reviews the GLHHERP program and indicators established to monitor and address the risks posed by these substances to vulnerable populations in the Great Lakes ecosystem.
SN - 0008-4263
AD - US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road NE, M/S E-29, Atlanta, GA 30329-4029; heh2@cdc.gov
U2 - PMID: 12425177.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106825995&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106792803
T1 - Reentry into clinical practice: challenges and strategies.
AU - Mark S
AU - Gupta J
AU - Mark, Saralyn
AU - Gupta, Jhumka
Y1 - 2002/09/04/
N1 - Accession Number: 106792803. Language: English. Entry Date: 20030103. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Job Re-Entry
KW - Medical Practice
KW - Physicians
KW - Family and Medical Leave
KW - Job Satisfaction
KW - Job Re-Entry -- Methods
KW - Needs Assessment
KW - Physicians -- Psychosocial Factors
KW - Clinical Competence
KW - Job Change
SP - 1091
EP - 1096
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 288
IS - 9
CY - Chicago, Illinois
PB - American Medical Association
AB - Women and men who reenter clinical practice after a period of clinical inactivity often face personal, professional, and institutional obstacles. Although many associations and academic medical institutions realize the critical importance of retaining and promoting highly qualified individuals, it is equally important for health care professionals to have the opportunity to return to a successful professional career following extended clinical inactivity. Here we provide a review of factors that may contribute to clinical inactivity, discuss challenges associated with the reentry process, describe current reentry efforts, and propose recommendations for future directions.
SN - 0098-7484
AD - Office on Women's Health, US Department of Health and Human Services, 200 Independence Ave SW, Room 730B, Washington, DC 20201, USA
AD - Office on Women's Health, US Department of Health and Human Services, 200 Independence Ave SW, Room 730B, Washington, DC 20201; smark@osophs.dhhs.gov
U2 - PMID: 12204077.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106792803&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Hyung Sik
AU - Han, Soon Young
AU - Kim, Tae Sung
AU - Kwack, Seung Jun
AU - Lee, Rhee Da
AU - Kim, In Young
AU - Seok, Ji-Hyun
AU - Lee, Byung Mu
AU - Yoo, Sun Dong
AU - Park, Kui Lea
T1 - No androgenic/anti-androgenic effects of bisphenol-A in Hershberger assay using immature castrated rats
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2002/09/05/
VL - 135
IS - 1/2
M3 - Article
SP - 111
SN - 03784274
AB - Several studies have demonstrated that bisphenol A (BPA) exhibited weak estrogenic activity in the 3-day uterotrophic assay using ovariectomized (OVX) and immature rats (Toxicol. Lett. 115 (2000) 231; Regul. Toxicol. Pharmacol. 32 (2000) 118; J. Toxicol. Sci. 26 (2001) 111) and BPA also possessed anti-androgenic activity in in vitro yeast based assays (J. Endocrinol. 158 (1998) 327). To investigate anti-androgenic effects of BPA. a rodent Hershberger assay was carried out using immature Sprague–Dawley male rats. An androgen agonist, testosterone (0.4 mg/kg per day), was administered for 7 consecutive days by subcutaneous (s.c.) injection as a positive control. Additionally, a pure androgen antagonist, flutamide (1, 5. 10 mg/kg per day. oral) was co-administered with testosterone (0.4 mg/kg per day s.c.). BPA was also administered orally with or without testosterone (0.4 mg/kg per day, s.c.) for 7 consecutive days. In the testosterone treated groups, glans penis, seminal vesicles, ventral prostate, and levator ani plus bulbocavernosus muscles (LABC) weights were significantly increased compared with control. However. flulamide dose-dependently inhibited the testosterone-induced re-growth of seminal vesicles, ventral prostate, and LABC, with a significant decrease at flutamide 1.0 mg/kg and above (P<0.05). Serum LH levels were also significantly increased (5 mg/kg and above, P<0.05), but no changes in serum testosterone levels. In contrast, BPA had no effects on the re-growth of seminal vesicles, ventral prostate and LABC induced by testosterone, and no significant differences were observed in serum LH and testosterone levels. In summary, the Hershberger assay could be a sensitive method for detecting androgenic or anti-androgenic chemicals, but BPA did not exhibit any androgenic or anti-androgenic activities in Hershberger assay. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Monomers
KW - Flutamide
KW - Bisphenol A
KW - Hershberger assay
KW - Testosterone
KW - Uterotrophic assay
N1 - Accession Number: 7877196; Kim, Hyung Sik 1; Han, Soon Young 1; Kim, Tae Sung 1; Kwack, Seung Jun 1; Lee, Rhee Da 1; Kim, In Young 1; Seok, Ji-Hyun 1; Lee, Byung Mu 2; Yoo, Sun Dong 2; Park, Kui Lea 1; Email Address: parkkl@kfda.go.kr; Affiliations: 1: Reproductive and Developmental Toxicology Division, Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, 122-704 Seoul, South Korea; 2: College of Pharmacy, Sungkyunkwan University, Kyunggi-do, 440-746 Suwon, South Korea; Issue Info: Sep2002, Vol. 135 Issue 1/2, p111; Thesaurus Term: Monomers; Subject Term: Flutamide; Author-Supplied Keyword: Bisphenol A; Author-Supplied Keyword: Hershberger assay; Author-Supplied Keyword: Testosterone; Author-Supplied Keyword: Uterotrophic assay; Number of Pages: 13p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=7877196&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baylor, Norman W.
AU - Egan, William
AU - Richman, Paul
T1 - Corrigendum to “Aluminum salts in vaccines—US perspective” [Vaccine 20 (Suppl. 2) (2002) S18–S23]
JO - Vaccine
JF - Vaccine
Y1 - 2002/09/10/
VL - 20
IS - 27/28
M3 - Correction notice
SP - 3428
SN - 0264410X
N1 - Accession Number: 7867648; Baylor, Norman W.; Email Address: baylor@cber.fda.gov; Egan, William 1; Richman, Paul 1; Affiliations: 1: Food and Drug Administration, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Bethesda, MD, USA; Issue Info: Sep2002, Vol. 20 Issue 27/28, p3428; Number of Pages: 1p; Document Type: Correction notice
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 119411741
T1 - From the Food and Drug Administration.
AU - Crawford, Lester M Jr
Y1 - 2002/09/11/
N1 - Accession Number: 119411741. Language: English. Entry Date: 20030103. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Indoles -- Therapeutic Use
KW - Organoplatinum Compounds -- Therapeutic Use
KW - Antineoplastic Agents -- Therapeutic Use
KW - Serotonin Agonists -- Therapeutic Use
KW - Inflammatory Bowel Diseases -- Drug Therapy
KW - Gastrointestinal Agents -- Therapeutic Use
KW - Needlestick Injuries -- Epidemiology
KW - Colorectal Neoplasms -- Drug Therapy
KW - Inflammatory Bowel Diseases -- Complications
KW - Female
KW - United States
KW - Constipation -- Complications
KW - United States Food and Drug Administration
KW - Male
SP - 1225
EP - 1225
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 288
IS - 10
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Deputy Commissioner, US Food and Drug Administration, Rockville, MD 20857, USA
U2 - PMID: 12215114.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106825606
T1 - Hantavirus pulmonary syndrome: a zebra worth knowing.
AU - Graziano KL
AU - Tempest B
Y1 - 2002/09/15/
N1 - Accession Number: 106825606. Language: English. Entry Date: 20030425. Revision Date: 20150711. Publication Type: Journal Article; CEU; diagnostic images; exam questions; pictorial. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Hantavirus Infections
KW - Education, Continuing (Credit)
KW - Hantavirus Infections -- Diagnosis
KW - Hantavirus Infections -- Epidemiology
KW - Hantavirus Infections -- Physiopathology
KW - Hantavirus Infections -- Symptoms
KW - Hantavirus Infections -- Transmission
KW - Patient Education
SP - 1015
EP - 1020
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 66
IS - 6
CY - Skokie, Illinois
PB - American Academy of Family Physicians
AB - Hantavirus pulmonary syndrome (HPS) is a severe cardiopulmonary illness most often caused by the Sin Nombre virus, which is transmitted to humans by inhalation of aerosolized particles of rodent excreta or direct rodent contact. Although HPS is more common in the western United States, cases have been identified in 31 states. The illness begins as a nonspecific febrile prodrome, sharing many of its initial symptoms with other more common viral infections. Patients then quickly develop noncardiogenic pulmonary edema, respiratory failure, and shock. Characteristic laboratory findings include thrombocytopenia, a left-shifted leukocytosis, hemoconcentration, and presence of immunoblasts. The overall case fatality rate of HPS is approximately 40 percent. Diagnosis is confirmed by serologic identification of IgM and IgG antibodies to Sin Nombre virus. There is no specific therapy, but early recognition of HPS during the prodromal phase can expedite initiating cardiopulmonary support in an intensive care unit, which is associated with improved survival rates. Prevention of HPS involves avoiding contact with rodents and rodent habitats.
SN - 0002-838X
AD - Tuba City Indian Medical Center, Navajo Area Indian Health Service, P.O. Box 600, Tuba City, AZ 86045; docgratz@yahoo.com
U2 - PMID: 12358213.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106817975
T1 - Assessing the use of activated protein C in the treatment of severe sepsis.
AU - Siegel JP
AU - Siegel, Jay P
Y1 - 2002/09/26/
N1 - Accession Number: 106817975. Language: English. Entry Date: 20030328. Revision Date: 20161128. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Blood Proteins -- Therapeutic Use
KW - Recombinant Proteins -- Therapeutic Use
KW - Sepsis -- Drug Therapy
KW - Apache
KW - Blood Proteins -- Adverse Effects
KW - Clinical Trials
KW - Comorbidity
KW - Drug Approval
KW - Hemorrhage -- Chemically Induced
KW - Recombinant Proteins -- Adverse Effects
KW - Sepsis -- Classification
KW - Sepsis -- Mortality
KW - United States
KW - United States Food and Drug Administration
SP - 1030
EP - 1034
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 347
IS - 13
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Center for Biologics Evaluation and Research, Rockville, MD 20852, USA
AD - Center for Biologics Evaluation and Research, Rockville, MD 20852
U2 - PMID: 12324563.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Qiao, G. L.
AU - Riviere, J. E.
T1 - SYSTEMIC UPTAKE AND CUTANEOUS DISPOSITION OF PENTACHLOROPHENOL IN A SEQUENTIAL EXPOSURE SCENARIO: EFFECTS OF SKIN PREEXPOSURE TO BENZO[a]PYRENE.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/09/30/
VL - 65
IS - 18
M3 - Article
SP - 1307
EP - 1331
SN - 15287394
AB - Characterizing interactions caused by sequential skin exposures to various environmental toxicants can be critical for a meaningful risk assessment. To assess sequential chemical exposure effect on chemical cutaneous disposition and systemic uptake of a toxicant, [[sup 14]C]pentachlorophenol (PCP) was topically administered in three porcine skin models (in vivo, ex vivo, and in vitro) at 40 µg/cm[sup 2] with or without skin preexposure to benzo[a]pyrene (BaP), a known human carcinogen and cutaneous cytochrome P-450 (CYP450) inducer. In the mass balance studies, BaP skin preexposure was found to enhance [sup 14]C absorption in all three models with detectable in vivo effect during the first several days. Total 8-h absorption was tripled by skin preexposure to BaP in the ex vivo (1.1 to 3.2%) and in vitro (0.20 to 0.66%) systems. As seen in the extended in vivo studies, total absorption was 50–57% regardless of exposure conditions, suggesting the prolonged observation period may conceal existing impact of potentially modified disposition processes, such as cutaneous metabolism, on systemic absorption. Skin preexposure to the skin CYP450 inducer BaP largely changed label penetration depth and distribution pattern in cutaneous tissues and decreased [sup 14]C concentration in skin and fat. Additionally, BaP preexposure altered [sup 14]C systemic tissue disposition, suggesting that altered cutaneous PCP disposition may eventually change the toxicity profile (cutaneous vs. systemic risk). The preliminary tissue distribution and systemic absorption data suggested that skin preexposure to BaP may considerably modify cutaneous biotransformation rate and thus deserves further investigation. The dermal model-dependent impacts of expected skin biotransformation manipulation by preexposure to chemicals such as BaP on cutaneous disposition and systemic uptake of environmental toxicants such as PCP need to be considered in risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pentachlorophenol
KW - Skin
N1 - Accession Number: 7253284; Qiao, G. L. 1; Riviere, J. E. 2; Affiliations: 1: Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina, USA; Issue Info: 2002, Vol. 65 Issue 18, p1307; Thesaurus Term: Pentachlorophenol; Subject Term: Skin; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 25p; Document Type: Article
L3 - 10.1080/00984100290071577
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Coffey, Christopher C.
AU - Lawrence, Robert B.
AU - Zhuang, Ziqing
AU - Campbell, Donald L.
AU - Jensen, Paul A.
AU - Myers, Warren R.
T1 - Comparison of Five Methods for Fit-Testing N95 Filtering-Facepiece Respirators.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/10//
VL - 17
IS - 10
M3 - Article
SP - 723
EP - 730
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Five fit-testing methods (Bitrex, ambient aerosol condensation nuclei counter using the TSI PortaCount Plus, saccharin, modified ambient aerosol condensation nuclei counter using the TSI PortaCount Plus with the N95-Companion, and generated aerosol using corn oil) were evaluated for their ability to identify poorly fitting N95 filtering-facepiece respirators. Eighteen models of NIOSH-certified, N95 filtering-facepiece respirators were tested by a panel of 25 subjects using each fit-testing method. The penetration of the corn oil and the ambient aerosols through the filter media of each respirator was measured in order to adjust the corresponding generated and ambient aerosol overall fit factors, reflecting only face-seal leakage. Fit-testing results were compared to 5th percentiles of simulated workplace protection factors. Beta errors (the chance of passing a fit-test in error) ranged from 3 percent to 11 percent. Alpha errors (the chance of failing a fit-test in error) ranged from 51 percent to 84 percent. The ambient aerosol using the TSI PortaCount Plus and the generated aerosol methods identified poorly fitting respirators better than the saccharin, the Companion, and Bitrex methods. These errors rates should be considered when selecting a fit-testing method for fitting N95 filtering-facepieces. When both types of errors were combined as an assignment error, the ambient aerosol method using the TSI PortaCount Plus had the lowest percentage of wearers being assigned a poor-fitting respirator. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Protective clothing
KW - Breathing apparatus
KW - FILTERING-FACEPIECE RESPIRATOR
KW - FIT-TEST
KW - SIMULATED WORKPLACE PROTECTION FACTOR
N1 - Accession Number: 7392657; Coffey, Christopher C. 1; Lawrence, Robert B. 1; Zhuang, Ziqing 2; Campbell, Donald L. 1; Jensen, Paul A. 1; Myers, Warren R. 3; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; 3: College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia; Issue Info: Oct2002, Vol. 17 Issue 10, p723; Thesaurus Term: Protective clothing; Subject Term: Breathing apparatus; Author-Supplied Keyword: FILTERING-FACEPIECE RESPIRATOR; Author-Supplied Keyword: FIT-TEST; Author-Supplied Keyword: SIMULATED WORKPLACE PROTECTION FACTOR; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10473220290107002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - J. Finlay, W. J.
AU - Logan, N. A.
AU - Sutherland, A. D.
T1 - Bacillus cereus emetic toxin production in relation to dissolved oxygen tension and sporulation
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/10//
VL - 19
IS - 5
M3 - Article
SP - 423
SN - 07400020
AB - Seven emetic toxin-producing strains of Bacillus cereus were examined for growth, sporulation and toxin production in skim milk medium in shaken and unshaken batch cultures under aerobic, microaerobic and anaerobic atmospheres. High levels of toxin production were detected in aerobic and microaerobic cultures. Static cultures yielded 90% less toxin than equivalent shaken cultures. Emetic toxin production was detected in aerobic and microaerobic cultures when bacterial counts reached > 6·0 log10 cfu ml−1, which also coincided with spore production. However, no correlation was found between spore count and toxin production (R2= 0·032). In anaerobic culture, production of emetic toxin was undetectable and the dissolved oxygen tension in the growth medium fell below 125±46 ppm within 6 h of inoculation. In aerobic culture, most toxin was produced between 16 and 22 h of incubation, when the dissolved oxygen tension had decreased to 60−70 ppm. Therefore, while O2-dependent respiration is fundamentally required for production of the emetic toxin, most toxin production occurs when little free oxygen is available. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxins
KW - Bacillus cereus
N1 - Accession Number: 8516161; J. Finlay, W. J. 1; Logan, N. A.; Sutherland, A. D.; Affiliations: 1: Current address: Centre for Biologics Evaluation and Research, US Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland, 20892, USA; Issue Info: Oct2002, Vol. 19 Issue 5, p423; Thesaurus Term: Toxins; Subject Term: Bacillus cereus; Number of Pages: 8p; Document Type: Article
L3 - 10.1006/fmic.2002.0504
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - J. Finlay, W. J.
AU - Logan, N. A.
AU - Sutherland, A. D.
T1 - Bacillus cereus emetic toxin production in cooked rice
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/10//
VL - 19
IS - 5
M3 - Article
SP - 431
SN - 07400020
AB - Three mesophilic strains of Bacillus cereus known to produce emetic toxin were used to model germination, growth and emetic toxin production in boiled rice cultures at incubation temperatures ranging from 8°C to 30°C. Minimum temperatures for germination and growth in boiled rice were found to be 15°C for all strains. Toxin production at 15°C was found to be significantly greater (P<0·01; reciprocal toxin titre of 373±124) than at 20°C and 30°C (reciprocal toxin titres 112±37 and 123±41, respectively). Toxin production became detectable after 48 h incubation at 15°C, with a maximum titre reached by 96 h. At 20°C and 30°C, toxin production was detected at 24 h incubation, with a maximum titre reached by 72 h. Toxin production at 15°C was detectable at lower bacterial counts (6·2 log10 cfu g−1), than with incubation at 20°C and 30°C (>7·0 log10 cfu g−1). In this study, the lower temperature limit for germination and growth on solid laboratory medium was found to be 12°C for all strains, i.e. 3°C lower than that observed in boiled rice. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxins
KW - Rice
KW - Bacillus cereus
N1 - Accession Number: 8516162; J. Finlay, W. J. 1,2; Logan, N. A. 1; Sutherland, A. D. 1; Affiliations: 1: School of Biological and Biomedical Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow, G4 OBA, Scotland, UK; 2: Current address: Centre for Biologics Evaluation and Research, US Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland, 20892, USA; Issue Info: Oct2002, Vol. 19 Issue 5, p431; Thesaurus Term: Toxins; Thesaurus Term: Rice; Subject Term: Bacillus cereus; NAICS/Industry Codes: 111160 Rice Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 9p; Document Type: Article
L3 - 10.1006/fmic.2002.0505
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=8516162&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stryer, Daniel B.
AU - Weinick, Robin M.
AU - Clancy, Carolyn M.
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality
AD - Center for Primary Care Research, Agency for Healthcare Research and Quality
AD - Agency for Healthcare Research and Quality
T1 - Reducing Racial and Ethnic Disparities in Health Care
JO - Health Services Research
JF - Health Services Research
Y1 - 2002/10//
VL - 37
IS - 5
SP - xv
EP - xxvi
SN - 00179124
N1 - Accession Number: 0668988; Keywords: Health Care; Health; Racial; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200312
KW - Analysis of Health Care Markets I11
KW - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination J15
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Hill, Steven C.
AU - Wooldridge, Judith
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality
AD - Mathematica Policy Research, Inc, Princeton
T1 - Plan Characteristics and SSI Enrollees' Access to and Quality of Care in Four TennCare MCOs
JO - Health Services Research
JF - Health Services Research
Y1 - 2002/10//
VL - 37
IS - 5
SP - 1197
EP - 1220
SN - 00179124
N1 - Accession Number: 0668992; Keywords: SSI; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200312
N2 - We compared enrollee reports of access and quality across the four MCOs using regression methods, and we use case study methods to assess whether patterns both within and across MCOs are consistent with the hypotheses. Plan networks, financial incentives, utilization management methods, and state requirements are important areas for further study, and, in the meantime, ongoing monitoring of SSI enrollees in each MCO may be important for detecting problems and successes.
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106729462
T1 - Work-related exacerbation of asthma.
AU - Henneberger PK
AU - Hoffman CD
AU - Magid DJ
AU - Lyons EE
Y1 - 2002/10//2002 Oct-Dec
N1 - Accession Number: 106729462. Language: English. Entry Date: 20040430. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Asthma
KW - Industry
KW - Occupational Exposure
KW - Work Environment
KW - Adult
KW - Chi Square Test
KW - Colorado
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Female
KW - Fisher's Exact Test
KW - Health Maintenance Organizations
KW - Interviews
KW - Mail
KW - Male
KW - Mantel-Haenszel Test
KW - Odds Ratio
KW - Prevalence
KW - Questionnaires
KW - Self Report
KW - T-Tests
KW - Telephone
KW - Wilcoxon Rank Sum Test
KW - Human
SP - 291
EP - 296
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 8
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Adults with asthma who had been enrolled in an HMO for at least a year were requested to complete a questionnaire about their health status. Approximately 25% of the 1,461 participants responded positively to 'Does your current work environment make your asthma worse?' and were classified as having workplace exacerbation of asthma. Those with workplace exacerbation were more likely to have never attended college, be current or former smokers, have a history of other respiratory diseases, have missed work or usual activities at least one day in the past for weeks, and report their asthma was moderate, severe, or very severe. Percentages with workplace exacerbation of asthma were highest for mining and construction (36%), wholesale and retail trade (33%), and public administration (33%), and lowest for educational services (22%), finance, insurance, and real estate (22%), and non-medical and non-educational services (18%). Future studies are needed for objective validation of self-reported workplace exacerbation, and to follow subjects prospectively to clarify the temporal sequence of workplace exacerbation and asthma severity, and how other respiratory conditions and smoking might contribute to work-related worsening of asthma.
SN - 1077-3525
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; pkh0@cdc.gov
U2 - PMID: 12412844.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106609464
T1 - Feasibility issues in reproductive biomonitoring of female flight attendants and teachers.
AU - Whelan EA
AU - Grajewski B
AU - Wood E
AU - Kwan L
AU - Nguyen M
AU - Schnorr TM
AU - Knecht EA
AU - Kesner JS
Y1 - 2002/10//
N1 - Accession Number: 106609464. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by an Interagency Agreement with the Federal Aviation Administration. NLM UID: 9504688.
KW - Air Travel
KW - Environmental Monitoring
KW - Occupations and Professions
KW - Reproductive Health -- Evaluation
KW - Women's Health
KW - Adult
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Diaries
KW - Female
KW - Interviews
KW - Menstrual Cycle
KW - P-Value
KW - Paired T-Tests
KW - Questionnaires
KW - Saliva -- Analysis
KW - Self Report
KW - Sleep
KW - Teachers
KW - Urinalysis
KW - Funding Source
KW - Human
SP - 947
EP - 955
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 44
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Flight attendants (FAs) may be at risk of adverse reproductive outcomes. We investigated the feasibility of biomonitoring studies in this mobile workforce. Forty-five female FAs and 26 female teachers (referents) collected daily urine and saliva samples for one menstrual cycle, provided daily diary data for approximately three months, and wore a wrist monitor to measure sleep disruption. A transport system enabled FAs to store samples while traveling. Overall, participation rates were low (37%) but of those recruited, over 90% of FAs and teachers completed the biomonitoring cycle. Data collection and sample integrity were not diminished by travel. Study methods resulted in good compliance and high quality data. It is possible to conduct studies of menstrual cycle function, sleep disruption, and circadian rhythm disruption in a mobile workforce potentially exposed to reproductive hazards.
SN - 1076-2752
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226; Ewhelan@cdc.gov
U2 - PMID: 12391774.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106609464&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106793436
T1 - Risk factors for Burkholderia cepacia complex colonization and infection among patients with cystic fibrosis.
AU - Walsh NM
AU - Casano AA
AU - Manangan LP
AU - Sinkowitz-Cochran RL
AU - Jarvis WR
Y1 - 2002/10//2002 Oct
N1 - Accession Number: 106793436. Language: English. Entry Date: 20030103. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0375410.
KW - Cystic Fibrosis -- Complications
KW - Burkholderia Infections -- Etiology
KW - Risk Factors
KW - Case Control Studies
KW - Questionnaires
KW - Data Analysis Software
KW - Fisher's Exact Test
KW - Chi Square Test
KW - Odds Ratio
KW - Confidence Intervals
KW - Convenience Sample
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
KW - Adult
KW - Male
KW - Female
KW - Human
SP - 512
EP - 517
JO - Journal of Pediatrics
JF - Journal of Pediatrics
JA - J PEDIATR
VL - 141
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0022-3476
AD - Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, Atlanta, Georgia
U2 - PMID: 12378190.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - LORD, ALEXANDRA M.
T1 - Contagious Divides: Epidemics and Race in San Francisco's Chinatown.
JO - Journal of the History of Medicine & Allied Sciences
JF - Journal of the History of Medicine & Allied Sciences
Y1 - 2002/10//
VL - 57
IS - 4
M3 - Book Review
SP - 505
EP - 506
SN - 00225045
AB - Reviewed: Contagious Divides: Epidemics and Race in San Francisco's Chinatown. Shah, Nayan.
KW - EPIDEMICS
KW - NONFICTION
KW - RACE relations
KW - PUBLIC health
KW - LIVING conditions
KW - CHINESE Americans
KW - CHINATOWNS
KW - SAN Francisco (Calif.)
KW - Shah, Nayan
KW - SHAH, Nayah
KW - CONTAGIOUS Divides: Epidemics & Race in San Francisco's Chinatown (Book)
N1 - Accession Number: 44626898; LORD, ALEXANDRA M. 1; Affiliations: 1 : Office of the Public Health Service Historian, U.S. Public Health Service, 18-23 Parklawn Building, 5600 Fishers Lane, Rockville, Maryland 20857; Source Info: Oct2002, Vol. 57 Issue 4, p505; Note: Publication Information: Berkeley: U. of California Pr., 2001. 384 pp.; Historical Period: 1875 to 1939; Subject Term: EPIDEMICS; Subject Term: NONFICTION; Subject Term: RACE relations; Subject Term: PUBLIC health; Subject Term: LIVING conditions; Subject Term: CHINESE Americans; Subject Term: CHINATOWNS; Subject: SAN Francisco (Calif.); Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Hirsh, Joseph
T1 - Trends in the Development of Voluntary Health Insurance in the United States.
JO - Southwestern Social Science Quarterly
JF - Southwestern Social Science Quarterly
Y1 - 1940/12//
VL - 21
IS - 3
M3 - Article
SP - 246
EP - 260
SN - 02761742
AB - This article discusses trends in the development of voluntary health insurance in the U.S. Despite the fact that this an account of events rather than issues, it seems desirable, at the very outset, to define what is meant by the term voluntary health insurance. As generally used, it refers to those plans in which groups of persons make periodic payments into a pooled fund for themselves, and frequently for their dependents, which is utilized in their behalf for medical services when needed. Several plans came into existence as a result of numerous and complex causes. While their essential framework can be traced far back into early Roman history, a rather good case can be made for the argument that the die was really cast when man exchanged status for contract, when the world was emerging from feudalism. The end of feudalism brought with it the end of personal responsibility, where it existed, of the overlord for those bound to him. Great shifts of population took place; new occupations replaced old ones.
KW - HEALTH insurance
KW - MEDICAL care
KW - HEALTH care reform
KW - MEDICAL policy
KW - HEALTH planning
KW - UNITED States
N1 - Accession Number: 16706671; Hirsh, Joseph 1; Affiliation: 1: United States Public Health Service.; Source Info: Dec1940, Vol. 21 Issue 3, p246; Subject Term: HEALTH insurance; Subject Term: MEDICAL care; Subject Term: HEALTH care reform; Subject Term: MEDICAL policy; Subject Term: HEALTH planning; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kahmann, Winifred C.
T1 - DEMAND URGENT FOR OCCUPATIONAL THERAPISTS.
JO - Journal of Exceptional Children
JF - Journal of Exceptional Children
Y1 - 1944/04//
VL - 10
IS - 7
M3 - Article
SP - 188
EP - 188
SN - 08875405
AB - The article reports on the demand for occupational therapists (OT) in hospitals. Expansion of the occupational therapy program in army hospitals to develop a fast recovery for patients. A definite classification has been established for the occupational therapist under the Medical Branch of Civil Service. OT has a challenging and fascinating job and one will not be bored with the job.
KW - OCCUPATIONAL therapists
KW - OCCUPATIONAL therapy
KW - HOSPITALS
KW - HEALTH promotion
KW - UNITED States
KW - UNITED States. Army
N1 - Accession Number: 20898951; Kahmann, Winifred C. 1; Affiliation: 1: Superintendent, Occupational Therapy, Office of the Surgeon General of the Army, War Dept., Washington, D. C.; Source Info: Apr1944, Vol. 10 Issue 7, p188; Subject Term: OCCUPATIONAL therapists; Subject Term: OCCUPATIONAL therapy; Subject Term: HOSPITALS; Subject Term: HEALTH promotion; Subject Term: UNITED States; Company/Entity: UNITED States. Army; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 621340 Offices of Physical, Occupational and Speech Therapists, and Audiologists; NAICS/Industry Codes: 928110 National Security; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Carter Jr., Jerry W.
T1 - CRITICAL EVALUATION OF NONDIRECTIVE THERAPY: Co-Editor's Introduction.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1948/07//
VL - 4
IS - 3
M3 - Proceeding
SP - 225
EP - 226
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article informs that at the annual meeting of the Editorial Board of the Journal of Clinical Psychology last September, the members present reported a growing concern among psychologists over some of the trends implied in the theory and practice of nondirective therapy. This concern related principally to the responsibilities of the counselor to the client, inter-professional relations, training responsibilities, qualifications of non-directive counselors, and several theoretical issues.
KW - CLIENT-centered psychotherapy
KW - CONFERENCES & conventions
KW - COUNSELOR & client
KW - THERAPEUTICS
KW - INTERPERSONAL relations
KW - CLINICAL psychology
N1 - Accession Number: 15795602; Carter Jr., Jerry W. 1; Affiliation: 1: United Stales Public Health Service.; Source Info: Jul1948, Vol. 4 Issue 3, p225; Subject Term: CLIENT-centered psychotherapy; Subject Term: CONFERENCES & conventions; Subject Term: COUNSELOR & client; Subject Term: THERAPEUTICS; Subject Term: INTERPERSONAL relations; Subject Term: CLINICAL psychology; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 2p; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carter Jr., Jerry W.
T1 - THE COMMUNITY SERVICES PROGRAM OF THE NATIONAL INSTITUTE OF MENTAL HEALTH, U. S. PUBLIC HEALTH SERVICE.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1950/04//
VL - 6
IS - 2
M3 - Article
SP - 112
EP - 117
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article reports on the community services program of the national institute of mental health, U. S. public health service. Following World War II, congressional hearings revealed that various mental and emotional disorders and inadequacies accounted for the rejection or discharge of 2,000,000 men by the armed services. It was found that more than half of the patients hospitalized in the United States on any given day--some 600,000--were mental patients, and that about 8,000,000 individuals in the country were suffering from some mental disorder. No adequate programs for the prevention and early treatment of mental illness existed anywhere in the country. A National Advisory Mental Health Council consisting of leading scientific and medical authorities is provided for in the National Mental Health Act. This body advises the Surgeon General on such matters as policy, the distribution of grant funds, personnel standards, and other problems relating to the program.
KW - MENTALLY ill -- Care
KW - MENTAL health
KW - NATIONAL health services
KW - HUMAN services
KW - PUBLIC health
KW - MENTALLY ill
KW - UNITED States
N1 - Accession Number: 15828812; Carter Jr., Jerry W. 1; Affiliation: 1: Chief Clinical Psychologist, Community Services Branch, National institute of Mental Health, U. S. Public Health Service.; Source Info: Apr1950, Vol. 6 Issue 2, p112; Subject Term: MENTALLY ill -- Care; Subject Term: MENTAL health; Subject Term: NATIONAL health services; Subject Term: HUMAN services; Subject Term: PUBLIC health; Subject Term: MENTALLY ill; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kotkov, Benjamin
AU - Murawski, Benjamin
T1 - A RORSCHACH STUDY OF THE PERSONALITY STRUCTURE OF OBESE WOMEN.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1952/10//
VL - 8
IS - 4
M3 - Article
SP - 391
EP - 396
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article cites the study to approach the adult female obese personality through the use of the Rorschach test. The authors' plan is (1) to determine if there are reliable and differentiating Rorschach quantitative indices which characterize the personality structure of obese women as contrasted with women within the ideal weight range, (2) to determine the degree in which these differentiating indices are present, and (3) to attempt to reconstruct a pattern of psychic-economic distribution of personality energy typical of the personality structure of obese women. Later papers will treat nuclear conflicts and crucial relationships in the personality of obese women as reflected in other projective techniques.
KW - MAN-woman relationships
KW - PERSONALITY
KW - PSYCHOLOGICAL tests
KW - DISTRIBUTION (Economic theory)
KW - PERSONALITY tests
KW - RORSCHACH Test
N1 - Accession Number: 15845237; Kotkov, Benjamin 1 Murawski, Benjamin 2; Affiliation: 1: U. S. Public Health Service. 2: Boston VA Mental Hygiene Unit.; Source Info: Oct1952, Vol. 8 Issue 4, p391; Subject Term: MAN-woman relationships; Subject Term: PERSONALITY; Subject Term: PSYCHOLOGICAL tests; Subject Term: DISTRIBUTION (Economic theory); Subject Term: PERSONALITY tests; Subject Term: RORSCHACH Test; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bailey, Pearce
T1 - Relationship and Research and Education in a National Program for Handicapped Children.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1954/04//
VL - 20
IS - 7
M3 - Article
SP - 289
EP - 293
SN - 00144029
AB - The article discusses the relationship between research on neurological and sensory disorders and education of exceptional children. The growth of services for the exceptional child has been paralleled by the growth of research devoted to the prevention, diagnosis and treatment of the disorders which demand the services. The aim is to eliminate blindness, deafness, cerebral palsy, epilepsy and other disorders which create the exceptional child. Scientists are attempting to find the biological basis for functions such as perception, learning and memory. Research, education and rehabilitation may have an opportunity to work together.
KW - EXCEPTIONAL children
KW - SPECIAL education
KW - MEDICAL research
KW - DISABILITY evaluation
KW - DIAGNOSIS
KW - MEDICAL rehabilitation
KW - SENSORY disorders in children
KW - PERCEPTUAL disorders
KW - COGNITIVE learning
N1 - Accession Number: 19788665; Bailey, Pearce 1; Affiliation: 1: Director of the National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, US Department of Health; Source Info: Apr1954, Vol. 20 Issue 7, p289; Subject Term: EXCEPTIONAL children; Subject Term: SPECIAL education; Subject Term: MEDICAL research; Subject Term: DISABILITY evaluation; Subject Term: DIAGNOSIS; Subject Term: MEDICAL rehabilitation; Subject Term: SENSORY disorders in children; Subject Term: PERCEPTUAL disorders; Subject Term: COGNITIVE learning; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Terrill Jr., James G.
T1 - Some Public Health Aspects of Radioactive Wastes.
JO - Bulletin of the Atomic Scientists
JF - Bulletin of the Atomic Scientists
Y1 - 1958/01//
VL - 14
IS - 1
M3 - Article
SP - 44
EP - 45
PB - Bulletin of the Atomic Scientists
SN - 00963402
N1 - Accession Number: 21385885; Terrill Jr., James G. 1; Affiliation: 1: Chief, Radiological Health Program, Bureau of State Services, Public Health Service; Source Info: Jan1958, Vol. 14 Issue 1, p44; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Monroe, Jack J.
AU - Hill, Harris E.
T1 - THE HILL-MONROE INVESTORY FOR PREDICTING ACCEPTATBILITY FOR PSYCHOTHERAPY IN THE INSTITUTIONALIZED NARCOTIC ADDICT.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1958/01//
VL - 14
IS - 1
M3 - Article
SP - 31
EP - 36
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article cites a study, which attempts to develop a self-administering inventory for selecting the individuals among a drug-addict population who are most acceptable for psychotherapy. The article also includes normative data based on a large number of subjects and presents correlations between the scale and other variables. Validity generalization tests of the predictive efficiency of the 46-item scale were then made on a group of 136 subjects. Differences were found between the two groups in responses to items designed to measure sensitivity to pain, kind and degree of hostility and aggression, as well as between items concerning preferred drug effects.
KW - DRUG addicts
KW - INVENTORIES
KW - PSYCHOTHERAPY
KW - PSYCHIATRY
KW - DRUGS -- Physiological effect
KW - MENTAL health counseling
N1 - Accession Number: 15847127; Monroe, Jack J. 1 Hill, Harris E. 1; Affiliation: 1: U. S. Public Health Service Hospital, Lexinton, Ky.; Source Info: Jan1958, Vol. 14 Issue 1, p31; Subject Term: DRUG addicts; Subject Term: INVENTORIES; Subject Term: PSYCHOTHERAPY; Subject Term: PSYCHIATRY; Subject Term: DRUGS -- Physiological effect; Subject Term: MENTAL health counseling; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosen, Albert
AU - Hales, William M.
AU - Peek, Roland M.
T1 - COMPARABILITY OF MMPI CARD AND BOOKLET FORMS FOR PSYCHIATRIC PATIENTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1958/10//
VL - 14
IS - 4
M3 - Article
SP - 387
EP - 388
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents information on the comparability of Minnesota Multiphasic Personality Inventory card and booklet forms for psychiatric patients. A random sample of 75 patients in the psychiatry service of a Virginia General Medical and Surgical Hospital was administered the booklet form of the MMPI. Another essentially random sample of 250 patients from the same service was administered the MMPI card form. When the two samples were compared on each scale mean and variance, no significant differences were found. MMPI scores obtained from either the card or booklet form may in general be treated as alternate forms in the type of population sampled in this study.
KW - MINNESOTA Multiphasic Personality Inventory
KW - PSYCHOTHERAPY patients
KW - PERSONALITY tests
KW - PSYCHIATRY
KW - BOOKLET Category Test
KW - VIRGINIA
N1 - Accession Number: 15845815; Rosen, Albert 1 Hales, William M. 2 Peek, Roland M. 3; Affiliation: 1: Slate College of Washington. 2: U. S. Public Health Service. 3: Hastings (Minn.) State Hospital.; Source Info: Oct1958, Vol. 14 Issue 4, p387; Subject Term: MINNESOTA Multiphasic Personality Inventory; Subject Term: PSYCHOTHERAPY patients; Subject Term: PERSONALITY tests; Subject Term: PSYCHIATRY; Subject Term: BOOKLET Category Test; Subject Term: VIRGINIA; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Richard Q.
T1 - RELATIONS BETWEEN BEHAVIOR MANIFESTATIONS IN THE HUMAN NEONATE.
JO - Child Development
JF - Child Development
Y1 - 1960/09//
VL - 31
IS - 3
M3 - Article
SP - 463
EP - 477
PB - Wiley-Blackwell
SN - 00093920
N1 - Accession Number: 16288998; Bell, Richard Q. 1; Affiliation: 1: Laboratory of Psychology, National Institute of Mental Health, National Institute of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland; Source Info: Sep1960, Vol. 31 Issue 3, p463; Number of Pages: 15p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Suster, E.
AU - Kirsanow, Eugene M.
T1 - Hyperreactivity to Endotoxin in Mice Infected with Mycobacteria. Induction and Elicitation of the Reactions.
JO - Immunology
JF - Immunology
Y1 - 1961/10//
VL - 4
IS - 4
M3 - Article
SP - 354
EP - 365
PB - Wiley-Blackwell
SN - 00192805
AB - In the mouse, the parenteral injection of whole mycobacteria, cord factor or mycobacterial cell walls induces a 100 to 500,000 fold decrease in the acute i/v LD50 of endotoxic lipopolysaccharide (LPS) of Gram-negative organisms. Non-specific hyperreactivity of this kind is more easily induced by infection with living mycobacteria than by injection of dead organisms, and more easily when these are injected intravenously than intraperitoneally; but BCG and other strains of low virulence are as effective as fully virulent strains such as H37RV or Vallée. The hyperreactivity reaches a maximum at 7–9 days and persists for at least 3 weeks. All of four strains of mice tested behaved similarly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - IMMUNE response
KW - MYCOBACTERIA
KW - BACTERIAL toxins
KW - ANTIGEN-antibody reactions
KW - MICE as carriers of disease
KW - IMMUNOLOGY
N1 - Accession Number: 12534120; Suster, E. 1,2 Kirsanow, Eugene M. 1,2; Affiliation: 1: Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida, U.S.A. 2: National Institute of Allergy and Infectious Diseases, National Institute of Health, United States Public Health Service; Source Info: Oct61, Vol. 4 Issue 4, p354; Subject Term: ENDOTOXINS; Subject Term: IMMUNE response; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL toxins; Subject Term: ANTIGEN-antibody reactions; Subject Term: MICE as carriers of disease; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolkon, George H.
AU - Haefner, Don P.
T1 - CHANGE IN EGO STRENGTH OF IMPROVED AND UNIMPROVED PSYCHIATRIC PATIENTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1961/10//
VL - 17
IS - 4
M3 - Article
SP - 352
EP - 355
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study, which investigates the change in ego strength of improved and unimproved psychiatric patients during rehabilitation. The general hypothesis of this study is that the personality variable of ego strength is a concomitant of overt behavior, changing as behavior is modified. The specific research prediction is that psychiatric patients, who show behavioral improvement as evidenced by discharge from the hospital, manifest greater increments in ego strength than patients who do not evidence such behavioral improvement.
KW - EGO (Psychology)
KW - EGOISM
KW - PSYCHOTHERAPY patients
KW - MENTALLY ill
KW - PSYCHOANALYSIS
KW - REHABILITATION
KW - ADJUSTMENT (Psychology)
N1 - Accession Number: 15843926; Wolkon, George H. 1 Haefner, Don P. 2; Affiliation: 1: Boston University. 2: United States Public Health Service.; Source Info: Oct1961, Vol. 17 Issue 4, p352; Subject Term: EGO (Psychology); Subject Term: EGOISM; Subject Term: PSYCHOTHERAPY patients; Subject Term: MENTALLY ill; Subject Term: PSYCHOANALYSIS; Subject Term: REHABILITATION; Subject Term: ADJUSTMENT (Psychology); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hilmar, Norman A.
T1 - Patients' Views of Medicine Practice.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1962///Spring1962
VL - 3
IS - 1
M3 - Book Review
SP - 52
EP - 53
SN - 00959006
AB - Reviews the book "Patients' Views of Medicine Practice," by Eliot Friedson.
KW - MEDICINE -- Practice
KW - NONFICTION
KW - FRIEDSON, Eliot
KW - PATIENTS' Views of Medicine Practice (Book)
N1 - Accession Number: 15176999; Hilmar, Norman A. 1; Affiliation: 1: United States Public Health Service; Source Info: Spring1962, Vol. 3 Issue 1, p52; Subject Term: MEDICINE -- Practice; Subject Term: NONFICTION; Reviews & Products: PATIENTS' Views of Medicine Practice (Book); People: FRIEDSON, Eliot; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lefcourt, Herbert M.
T1 - CLINICAL CORRELATES OF DOGMATISM.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1962/07//
VL - 18
IS - 3
M3 - Article
SP - 327
EP - 328
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study that investigates the clinical validity of the dogmatism construct as applied to the classification of clinical cases regarding readiness for therapy. The study lends support for the validity of the dogmatism construct by extending the construct's use through clinical diagnostic categories that rely on similar dimensions as dogmatism. It informs that dogmatism is inversely related to learning, though in this study. The study was concerned with judged potential for learning rather than actual learning per se.
KW - DOGMATISM
KW - ATTITUDE (Psychology)
KW - PERSONALITY
KW - LEARNING
KW - PREPAREDNESS
KW - RIGIDITY (Psychology)
N1 - Accession Number: 15846814; Lefcourt, Herbert M. 1; Affiliation: 1: U. S. Public Health Service Hospital, Lexington, Kentucky.; Source Info: Jul1962, Vol. 18 Issue 3, p327; Subject Term: DOGMATISM; Subject Term: ATTITUDE (Psychology); Subject Term: PERSONALITY; Subject Term: LEARNING; Subject Term: PREPAREDNESS; Subject Term: RIGIDITY (Psychology); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brewster, Agnes W.
AU - Allen, Scott I.
AU - Kramer, Lucy M.
T1 - EXPERIENCE WITH A PREPAID DRUG BENEFIT.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1963///Spring1963
VL - 4
IS - 1
M3 - Article
SP - 14
EP - 22
SN - 00959006
AB - In the health insurance movement, the provision of drugs has been one of the medical needs least well met. One prepaid medical care plan has pioneered in an effort to meet this need, and its precise experience is reported in this paper. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Human Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH maintenance organizations
KW - HEALTH insurance
KW - HEALTH planning
KW - MEDICAL care
KW - PUBLIC health
KW - HEALTH facilities
N1 - Accession Number: 15177614; Brewster, Agnes W. 1 Allen, Scott I. 2 Kramer, Lucy M. 2; Affiliation: 1: Chief, Health Economics Branch, Div. of Community Health Services, Public Health Service, U.S. Dept. of Health, Education, and Welfare, Washington 25, D.C. 2: Health Economics Branch, Div. of Community Health Services, Public Health Service, Washington, D.C.; Source Info: Spring1963, Vol. 4 Issue 1, p14; Subject Term: HEALTH maintenance organizations; Subject Term: HEALTH insurance; Subject Term: HEALTH planning; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: HEALTH facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robbins, Paul R.
T1 - Level of anxiety, interference proneness, and defensive reactions to fear-arousing information.
JO - Journal of Personality
JF - Journal of Personality
Y1 - 1963/06//
VL - 31
IS - 2
M3 - Article
SP - 163
PB - Wiley-Blackwell
SN - 00223506
N1 - Accession Number: 8933160; Robbins, Paul R. 1; Affiliation: 1: Behavioral Science Section, Public Health Service.; Source Info: Jun63, Vol. 31 Issue 2, p163; Number of Pages: 16p; Document Type: Article
L3 - 10.1111/1467-6494.ep8933160
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DB - aph
ER -
TY - JOUR
AU - Hamburger, R. N.
AU - Pious, D. A.
AU - Mills, S. E.
T1 - Antigenic Specificities Acquired from the Growth Medium by Cells in Tissue Culture.
JO - Immunology
JF - Immunology
Y1 - 1963/09//
VL - 6
IS - 5
M3 - Article
SP - 439
EP - 449
PB - Wiley-Blackwell
SN - 00192805
AB - Studies employing quantitative complement fixation have shown that HeLa and other mammalian cells grown in tissue culture adsorb serum protein components from the growth medium, The serum proteins are not completely removed by vigorous washing, Upon injection of extensively washed cells with rabbits the bound serum proteins give rise to specific antibodies delectable by gel diffusion and complement fixation. With horse serum in the growth medium one of the cell-bound components was identified as horse γ globulin. Evidence was obtained that specific antibodies to bound serum antigens can contribute to complement-dependent kill of the cells in vitro. These observations suggest one possible mechanism for the acquisition of antigenic relationships by diverse cell lines grown in tissue culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLULAR growth
KW - TISSUE culture
KW - CELL lines
KW - IMMUNOGLOBULINS
KW - BLOOD proteins
KW - ANTIGENS
KW - RABBITS as laboratory animals
KW - IMMUNODIFFUSION
N1 - Accession Number: 12800322; Hamburger, R. N. 1 Pious, D. A. 2 Mills, S. E. 3; Affiliation: 1: National Institute of Neurological Diseases and Blindness, U.S. Public Health Service. 2: Division of General Medical Sciences, U.S. Public Health. 3: Biology Department, University of California, San Diego, La Jolla, California.; Source Info: Sep63, Vol. 6 Issue 5, p439; Subject Term: CELLULAR growth; Subject Term: TISSUE culture; Subject Term: CELL lines; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD proteins; Subject Term: ANTIGENS; Subject Term: RABBITS as laboratory animals; Subject Term: IMMUNODIFFUSION; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 11p; Document Type: Article
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ER -
TY - JOUR
AU - Nickols, John
AU - Nickols, Marcia
T1 - BRIEF FORMS OF THE WISC FOR RESEARCH.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1963/10//
VL - 19
IS - 4
M3 - Article
SP - 425
EP - 425
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article presents a study which investigates whether intelligence quotient (IQ) is divided from digit span, picture completion and information arithmetic scale and has comparable expediency with the Wechsler Intelligence Scale for Children (WISC). For the study 74 children were considered for the psychological test. The study depicted that arithmetic, information, picture completion and digit span have expediency in estimating the WISC Full Scale IQ.
KW - WECHSLER Intelligence Scale for Children
KW - CHILDREN -- Intelligence testing
KW - PSYCHOLOGY -- Methodology
KW - INTELLIGENCE levels
KW - PSYCHOLOGICAL tests
KW - INTELLIGENCE tests
N1 - Accession Number: 16763527; Nickols, John 1,2 Nickols, Marcia 1; Affiliation: 1: Arlington County Schools, Arlington, Va. 2: U. S. Public Health Service Outpatient Clinic, Washington, D. C.; Source Info: Oct1963, Vol. 19 Issue 4, p425; Subject Term: WECHSLER Intelligence Scale for Children; Subject Term: CHILDREN -- Intelligence testing; Subject Term: PSYCHOLOGY -- Methodology; Subject Term: INTELLIGENCE levels; Subject Term: PSYCHOLOGICAL tests; Subject Term: INTELLIGENCE tests; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colberg, J. E.
AU - Ddray, S.
T1 - Localization by Immunofluorescence of Gamma-Globulin Allotypes in Lymph Node Cells of Homozygous and Heterozygous Rabbits.
JO - Immunology
JF - Immunology
Y1 - 1964/05//
VL - 7
IS - 3
M3 - Article
SP - 273
EP - 290
PB - Wiley-Blackwell
SN - 00192805
AB - The cellular production of two rabbit γ-globulin allotypic specificities, A4 and A5, determined by allelic genes was investigated by the fluorescent antibody method. The 7S γ-globulin fractions of precipitating antisera were conjugated to fluorescein isothiocyanate and to lissamine rhodamine B sulphonyl chloride. Frozen sections of lymph nodes from eighteen rabbits, A4-A4 and A5-A5 homozygotes and A4-A5 heterozygotes, were studied after exposure to the fluorescent antibody conjugates. The conjugates, each specific for antigenic determinants of 7S γ-globulin, reacted specifically with the cytoplasm of plasma cells and intrinsic cells of the germinal centres. The rabbit anti-A4 conjugate reacted only with lymph node cells of A4-A4 and A4-A5 rabbits; the rabbit anti-A5 conjugates reacted only with cells of A5-A5 and A4-A5 rabbits; the horse anti-rabbit γ-globulin conjugates reacted with cells of all three genotypes. By a variety of techniques, identical cellular localization of the two allotypes, A4 and A5, was found in the A4-A5 heterozygotes. Less than 1 per cent of the cells in any heterozygous lymph node section contained one allotype without the other. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - GAMMA globulins
KW - BLOOD proteins
KW - RABBITS
KW - LYMPH nodes
KW - IMMUNE system
N1 - Accession Number: 13274303; Colberg, J. E. 1 Ddray, S. 2; Affiliation: 1: Department of Surgery, Univesity Hospital, Cleveland 6, Ohio, U.S.A. 2: Department of Health, Education and Welfare, Public Health Service, National Institute of Health Institute of Allergy and Infectious Diseases, Laboratory of Immunology, Bethesda, Maryland, U.S.A.; Source Info: May64, Vol. 7 Issue 3, p273; Subject Term: CELL proliferation; Subject Term: GAMMA globulins; Subject Term: BLOOD proteins; Subject Term: RABBITS; Subject Term: LYMPH nodes; Subject Term: IMMUNE system; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112930 Fur-Bearing Animal and Rabbit Production; Number of Pages: 20p; Document Type: Article
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ER -
TY - JOUR
AU - Sanders, Barkev S.
T1 - COMPLETENESS AND RELIABILITY OF DIAGNOSES IN THERAPEUTIC PRACTICE.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1964///Summer/Fall1964
VL - 5
IS - 2/3
M3 - Article
SP - 84
EP - 94
SN - 00959006
AB - Because individuals who see a doctor are self-selected; because doctors vary in their diagnostic competence, and this variation is not random with reference to various segments of the population; because both patient and doctor are primarily interested in relieving the patient, not assessing his general health, many persons have undiagnosed conditions. Incorrect diagnosis and tests occur even when objective clinical procedures are used. These are among the factors causing the low validity of the morbidity survey as a measure of prevalence of disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Human Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSICIANS
KW - DIAGNOSIS
KW - HEALTH
KW - SYMPTOMS
KW - DISEASES
KW - HEALTH surveys
N1 - Accession Number: 15177682; Sanders, Barkev S. 1; Affiliation: 1: Research Consultant, Division of Community Health Services, Public Health Service, U. S. Department of Health, Education, and Welfare, Washington, D. C.; Source Info: Summer/Fall1964, Vol. 5 Issue 2/3, p84; Subject Term: PHYSICIANS; Subject Term: DIAGNOSIS; Subject Term: HEALTH; Subject Term: SYMPTOMS; Subject Term: DISEASES; Subject Term: HEALTH surveys; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 11p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Loring, William C.
T1 - RESIDENTIAL ENVIRONMENT: NEXUS OF PERSONAL INTERACTIONS AND HEALTHFUL DEVELOPMENT.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1964///Winter1964
VL - 5
IS - 4
M3 - Article
SP - 166
EP - 169
SN - 00959006
AB - The article focuses on the physical aspects of a residential environment's relation to social interaction which affects individual well-being. Health-related social processes, such as socialization of the young or adjustment of the aged, may be hindered or facilitated by the physical arrangements affecting interaction in the family, friend-family and peer groups. What sociologists call the socialization-process produces a person's ability, expectations, values and habits for successful or deviant social life. The social interactions necessary in that process are crucial to that aspect of an individual's well-being which is social, rather than physical or mental, in its etiology. Accordingly, a physical residential environment affords social well-being, when it is one in which the primary groups vital to an individual's socialization and development are able to carry out their functions effectively. This frames a researchable hypothesis with which to join in the health practitioner's search for criteria to guide his work.
KW - SOCIAL interaction
KW - OLDER people -- Health
KW - WELL-being
KW - SOCIALIZATION
KW - DISEASES -- Causes & theories of causation
KW - SOCIAL psychology
N1 - Accession Number: 15177028; Loring, William C. 1; Affiliation: 1: Division of Environmental Engineering and Food Protection, U. S. Public Health Service, Washington, D. C.; Source Info: Winter1964, Vol. 5 Issue 4, p166; Subject Term: SOCIAL interaction; Subject Term: OLDER people -- Health; Subject Term: WELL-being; Subject Term: SOCIALIZATION; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: SOCIAL psychology; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bigman, Stanley K.
T1 - OCCUPATIONAL HEALTH AND SOCIAL RESEARCH (Book).
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1964///Winter1964
VL - 5
IS - 4
M3 - Article
SP - 170
EP - 176
SN - 00959006
AB - The article discusses some of the social factors in the etiology, control and prevention of occupational illnesses, some recent trends in the field of occupational health and some of the current research in the Division of Occupational Health of the Public Health Service. The social etiology of these diseases is self-evident. That is, an illness comes about because a particular occupation has developed around the exploitation of the discovered properties of parts of the non-human environment of occupational illnesses. Some of the cases of occupational illness is discussed. In each of the cases it is apparent that the disease was a product of the ecosystem as a whole, occurring when a particular development of technology and a particular kind of social organization brought one segment of the population into contact with a harmful part of the physical environment and vanishing when a change in the social organization changed the technology and broke the contact. Occupational health has been concerned principally with physical illnesses, resulting from contact with harmful components of the physical environment among manual workers.
KW - INDUSTRIAL hygiene
KW - SOCIAL factors
KW - ENVIRONMENTAL health
KW - DISEASES -- Causes & theories of causation
KW - INDUSTRIAL management
KW - PUBLIC health
N1 - Accession Number: 15177029; Bigman, Stanley K. 1; Affiliation: 1: Chief, Social Studies Section, Division of Occupational Health, U. S. Public Health Service, Washington, D. C.; Source Info: Winter1964, Vol. 5 Issue 4, p170; Subject Term: INDUSTRIAL hygiene; Subject Term: SOCIAL factors; Subject Term: ENVIRONMENTAL health; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: INDUSTRIAL management; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alderman, Michael H.
T1 - Why We Need Medicare.
JO - New Republic
JF - New Republic
Y1 - 1964/12/26/
VL - 151
IS - 26
M3 - Article
SP - 17
EP - 20
SN - 00286583
AB - Calls for the U.S. government to recognize medical care for the aged as a national obligation as of 1964. Results of the vague and permissive guidelines established by Congress; Provisions of the Social Security Act of 1960; Weaknesses produced by the state implementation of medical care programs under the Act; Examples of exclusions and limitations that curtail the value of private insurance; Objections of the American Medical Association to Medicare.
KW - MEDICAL care -- United States
KW - MEDICAL care for the aged
KW - SOCIAL security -- Law & legislation
KW - MEDICARE
KW - HEALTH insurance -- United States
KW - UNITED States
N1 - Accession Number: 10013939; Alderman, Michael H. 1; Affiliation: 1: US Public Health Service, National Institutes of Health, Bethesda, Maryland; Source Info: 12/26/64, Vol. 151 Issue 26, p17; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care for the aged; Subject Term: SOCIAL security -- Law & legislation; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Surwillo, Walter W.
AU - Quilter, Reginald E.
T1 - THE RELATION OF FREQUENCY OF SPONTANEOUS SKIN POTENTIAL RESPONSES TO VIGILANCE AND TO AGE.
JO - Psychophysiology
JF - Psychophysiology
Y1 - 1965/01//
VL - 1
IS - 3
M3 - Article
SP - 272
EP - 276
SN - 00485772
AB - Skin potential (Tarchanoff effect) was recorded in 132 healthy males, aged 22 to 85 years. while they performed an hour-long watchkeeping task. Vigilance level, as measured by S's detection or failure to detect certain critical stimuli, proved to be related to frequency of spontaneous skin potential responses (SPRs) in an interval immediately preceding the stimulus. Low vigilance was associated with fewer spontaneous SPRs per unit of time than high vigilance. This relationship did not appear to be the result of a correlation of the physiological and behavioral variables with time or with age. Old persons evinced a smaller number of spontaneous SPRs in a standard time interval than young persons. Lacey and Lacey's hypothesis that autonomic "labiles," or Ss who show a large number of spontaneous autonomic responses, have shorter reaction times than autonomic "stabiles" was confirmed. A related hypothesis. in which number of erroneous motor responses was the dependent variable. was not substantiated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GALVANIC skin response
KW - VIGILANCE (Psychology)
KW - SIGNAL detection (Psychology)
KW - CONDITIONED response
KW - MALES
KW - BEHAVIORISM (Psychology)
KW - AGE
KW - Aging.
KW - Autonomic
KW - Skin Potential
KW - Spontaneous SPR
KW - Tarchanoff effect
KW - Vigilance
KW - Watchkeeping
N1 - Accession Number: 11044659; Surwillo, Walter W. 1 Quilter, Reginald E. 1; Affiliation: 1: National Institutes of Health, U. S. Public Health Service, Bethesda, Maryland.; Source Info: Jan1965, Vol. 1 Issue 3, p272; Subject Term: GALVANIC skin response; Subject Term: VIGILANCE (Psychology); Subject Term: SIGNAL detection (Psychology); Subject Term: CONDITIONED response; Subject Term: MALES; Subject Term: BEHAVIORISM (Psychology); Subject Term: AGE; Author-Supplied Keyword: Aging.; Author-Supplied Keyword: Autonomic; Author-Supplied Keyword: Skin Potential; Author-Supplied Keyword: Spontaneous SPR; Author-Supplied Keyword: Tarchanoff effect; Author-Supplied Keyword: Vigilance; Author-Supplied Keyword: Watchkeeping; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Palmer, C. Mervin
T1 - Phytoplankton Periodicity in a Newfoundland Pond.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1965/03//
VL - 1
IS - 1
M3 - Article
SP - 39
EP - 40
SN - 00223646
AB - In 1954 a boiler-scale problem developed in a power plant at Argentia, Newfoundland. It was suggested that the algae in the water supply coming from Clarks pond might be partly responsible. After a visit to Argentia to determine the effectiveness of a diatomite filter which had been suggested to remove the algae from the water supply, weekly samples were analyzed microscopically for over 4 years because of early evidence of a periodicity among the dominant algae. Clarks pond is approximately 2800 feet long and 1200 feet wide at its greater dimensions and has a maximum capacity of almost 100 million gallons. The water is relatively clean, with a turbidity of 10 mg/l and is very corrosive being O[sub2]-saturated. The outstanding feature of the phytoplankton in Clarks pond is the reappearance each year of an essentially similar succession of the algal pulses.
KW - PHYTOPLANKTON
KW - PONDS
KW - ALGAE
KW - POWER plants
KW - ARGENTIA (N.L.)
KW - NEWFOUNDLAND & Labrador
KW - CANADA
N1 - Accession Number: 11628494; Palmer, C. Mervin 1; Affiliation: 1: U. S. Department of Health, Education, and Welf- are, Public Health Service. Robert A. Taft Sanitary Engineering Center, Cincinnati, Ohio.; Source Info: Mar1965, Vol. 1 Issue 1, p39; Subject Term: PHYTOPLANKTON; Subject Term: PONDS; Subject Term: ALGAE; Subject Term: POWER plants; Subject Term: ARGENTIA (N.L.); Subject Term: NEWFOUNDLAND & Labrador; Subject Term: CANADA; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112519 Other Aquaculture; NAICS/Industry Codes: 237130 Power and Communication Line and Related Structures Construction; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nichols, John
T1 - SELF-IMAGE RATINGS OF NORMAL AND DISTURBED SUBJECTS.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1966///Spring1966
VL - 7
IS - 1
M3 - Article
SP - 28
EP - 36
SN - 00959006
AB - Since man tends to seek an awareness of his own significance through his inter- action with others, he is challenged inadvertantly to achieve a sense of self-en- hancement or individuality without resorting to excessive self-deceit, self-exhaltation or self-depreciation. It seemed consistent with this perspective that 75 non-psychiatric adults obtained higher mean scores on the self-administered Self-Image Rating Scale than 40 schizophrenics, whose ratings suggested the assimilation of self-images denoting real or imagined social isolation. High scores could be used to suggest attitudes about the self or others which appear well regulated by subjective experiences of oneself as a social being. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Human Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SELF-perception
KW - PEOPLE with disabilities
KW - MENTAL disabilities
KW - PSYCHIATRIC errors
KW - SOCIAL isolation
KW - SOCIAL psychology
N1 - Accession Number: 14229916; Nichols, John 1; Affiliation: 1: Mental Health Service, U. S. Public Health Service Outpatient Clinic, Washington, D. C.; Source Info: Spring1966, Vol. 7 Issue 1, p28; Subject Term: SELF-perception; Subject Term: PEOPLE with disabilities; Subject Term: MENTAL disabilities; Subject Term: PSYCHIATRIC errors; Subject Term: SOCIAL isolation; Subject Term: SOCIAL psychology; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ochota, Leszek
T1 - What Is the Clinical Evidence?
JO - New Republic
JF - New Republic
Y1 - 1966/05/14/
VL - 154
IS - 20
M3 - Article
SP - 21
EP - 22
SN - 00286583
AB - Explores the clinical evidence for the mechanism of action of the hallucinogenic drug lysergic acid diethylamide or LSD. Stages of action of LSD in a human being; Implications of the psychotic reactions to LSD; Clinical indications for the administration of LSD; Adverse reactions from hallucinogens; Dangers of the self-administration of LSD.
KW - LSD (Drug)
KW - HALLUCINOGENIC drugs
KW - PSYCHIATRIC drugs
KW - PSYCHOSES
KW - CLINICAL indications
N1 - Accession Number: 10508546; Ochota, Leszek 1; Affiliation: 1: Food and Drug Administration; Source Info: 5/14/66, Vol. 154 Issue 20, p21; Subject Term: LSD (Drug); Subject Term: HALLUCINOGENIC drugs; Subject Term: PSYCHIATRIC drugs; Subject Term: PSYCHOSES; Subject Term: CLINICAL indications; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, J.
AU - Frei, J. V.
AU - Cohen, J. J.
AU - Rose, B.
AU - Richter, M.
T1 - Basement Membrane Specific Antisera Produced to Solubilized Tissue Fractions.
JO - Immunology
JF - Immunology
Y1 - 1966/08//
VL - 11
IS - 2
M3 - Article
SP - 155
EP - 162
PB - Wiley-Blackwell
SN - 00192805
AB - Attempts were made to produce antisera to solubilized tissue fractions rich in basement membranes and reticulin. Murine tissue fractions solubilized with sodium hydroxide elicited precipitating antibodies upon injection into rabbits. Although no nephrotoxic effect was observed upon injecting the rabbit antisera into mice, the antisera were fixed to the glomerular basement membrane, and not elsewhere, within 5 minutes of injection and remained fixed for at least 3 weeks. Specificity studies suggested that in addition to unique antigens, reticulin and epithelial basement membranes share a common antigen which is responsible for the similar in vitro immunofluorescence produced by antisera to tissue fractions rich in one or the other of these components. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BASAL lamina
KW - IMMUNE serums
KW - TISSUES
KW - SODIUM hydroxide
KW - IMMUNOGLOBULINS
KW - RABBITS as laboratory animals
KW - ANTIGENS
N1 - Accession Number: 13284172; Myers, J. 1 Frei, J. V. 2 Cohen, J. J. 3,4 Rose, B. 3,4 Richter, M. 5; Affiliation: 1: United States Public Health Service Special Research Fellow. 2: Research Associate, National Cancer Institute of Canada. 3: Division of Immunochemistry and Allergy, Royal Victoria, Hospital, Canada. 4: Department of Pathology, McGill University, Montreal, Quebec, Canada. 5: Medical Research Associate, Medical Research Council, Canada.; Source Info: Aug66, Vol. 11 Issue 2, p155; Subject Term: BASAL lamina; Subject Term: IMMUNE serums; Subject Term: TISSUES; Subject Term: SODIUM hydroxide; Subject Term: IMMUNOGLOBULINS; Subject Term: RABBITS as laboratory animals; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325181 Alkali and chlorine manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mergenhagen, S. E.
AU - Notkins, A. L.
AU - Evans, R. T.
T1 - Passive Haemagglutination for Estimation of Early and Late Anti-Human γ-Globulin Antibodies.
JO - Immunology
JF - Immunology
Y1 - 1966/09//
VL - 11
IS - 3
M3 - Article
SP - 223
EP - 228
PB - Wiley-Blackwell
SN - 00192805
AB - The influence of various concentrations of human y-globulin (HGG) employed to sensitize tanned sheep erythrocytes on haemagglutination titres with various early and late mouse and rabbit antisera to HGG has been studied. The concentration of HGG employed to sensitize tanned erythrocytes which gives the highest haemagglutination titres with early, mercaptoethanol- sensitive antibodies was not optimal for obtaining highest haemagglutination titres with late, mercaptoethanol-insensitive antibodies. Similar results were obtained with heavy and light sucrose gradient ultracentrifugation fractions of a late and early rabbit antiserum. These findings may account for past discrepancies and should be considered when employing the haemagglutination test to detect early and late antibodies.
KW - GAMMA globulins
KW - IMMUNOGLOBULINS
KW - AGGLUTINATION of blood
KW - IMMUNE serums
KW - ERYTHROCYTES
KW - ANTIGEN-antibody reactions
N1 - Accession Number: 14578238; Mergenhagen, S. E. Notkins, A. L. 1 Evans, R. T. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, .National Institute of Dental Research, Bethesda, Maryland 20014; Source Info: Sep66, Vol. 11 Issue 3, p223; Subject Term: GAMMA globulins; Subject Term: IMMUNOGLOBULINS; Subject Term: AGGLUTINATION of blood; Subject Term: IMMUNE serums; Subject Term: ERYTHROCYTES; Subject Term: ANTIGEN-antibody reactions; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linn, Erwin L.
T1 - SOCIAL MEANINGS OF DENTAL APPEARANCE.
JO - Journal of Health & Human Behavior
JF - Journal of Health & Human Behavior
Y1 - 1966///Winter1966
VL - 7
IS - 4
M3 - Article
SP - 289
EP - 295
SN - 00959006
AB - In a nation-wide survey about dental care and attitudes, questions were asked about the importance of dental appearance. At the end of the interviews, interviewers rated visibly mining or stained teeth. They judged also if any self-conscious behavior about dental appearance had occurred during the interview. Findings indicate high public awareness that dental appearance may be important, but kinds of social situations and characteristics of participants were obviously qualifications of attitudes. Attitudes were not qualified by respondents' social background or status. Their dental appearance and whether or not they were self-conscious during the interview were so qualified. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Human Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - ATTITUDES toward health
KW - TEETH abnormalities
KW - AWARENESS
KW - SOCIAL status
KW - SOCIAL psychology
N1 - Accession Number: 14238124; Linn, Erwin L. 1; Affiliation: 1: Education & Facilities Branch, Div. of Dental Health, U.S. Public Health Service, 14th Avenue & Lake St., San Francisco, Calif.; Source Info: Winter1966, Vol. 7 Issue 4, p289; Subject Term: DENTAL care; Subject Term: ATTITUDES toward health; Subject Term: TEETH abnormalities; Subject Term: AWARENESS; Subject Term: SOCIAL status; Subject Term: SOCIAL psychology; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nickols, John
T1 - RORSCHACH Z SCORES ON OUTPATIENTS.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1967/01//
VL - 23
IS - 1
M3 - Article
SP - 111
EP - 114
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - This article discusses Rorschach Z scores on outpatients. Forty Ss were observed. The mean age for 20 children was 9.9 ± 3.0. These cases included 13 adjustment reactions, 1 phobic reaction, 3 children who presented behavior problems and 3 who were considered to be severely disturbed. The mean age for 20 adults was 39 ± 13. Psychiatric diagnoses included 2 borderline psychoses, 3 schizoid and 1 paranoid personalities, 1 involutional and 7 anxiety reactions, and 4 obsessive-compulsive and 1 hysteric neuroses. One case was essentially normal.
KW - BEHAVIOR disorders in children
KW - DIAGNOSIS
KW - BEHAVIOR
KW - PSYCHIATRIC diagnosis
KW - SYMPTOMS
KW - PERSONALITY
N1 - Accession Number: 15844571; Nickols, John 1; Affiliation: 1: Mental Health Service, U. S. Public Health Service Outpatient Clinic, Washington, D.C.; Source Info: Jan1967, Vol. 23 Issue 1, p111; Subject Term: BEHAVIOR disorders in children; Subject Term: DIAGNOSIS; Subject Term: BEHAVIOR; Subject Term: PSYCHIATRIC diagnosis; Subject Term: SYMPTOMS; Subject Term: PERSONALITY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Reynolds, Michael D.
AU - Draine, Bruce
AU - Greenly, John
AU - Garland, David
AU - Pyenson, Lewis
AU - Schwartz, Richard A.
AU - Davison, Gerald C.
T1 - Correspondence.
JO - New Republic
JF - New Republic
Y1 - 1967/02/18/
VL - 156
IS - 7
M3 - Letter
SP - 34
EP - 36
SN - 00286583
AB - Presents letters to the editor referencing articles and topics discussed in previous issues. "Sorry 'Bout That," which asked for statistics on Vietnam war casualties; "Who's Fit to Be Free," which demonstrated difficulties that arise when non-psychotic criminals are handled as though they were mentally ill; Comparison of the Supersonic Transport boom intensities with those generated by U.S. Air Force aircraft during the supersonic overflights of various cities.
KW - LETTERS to the editor
KW - WAR casualties -- Statistics
KW - MENTALLY ill
KW - CRIMINALS
KW - SUPERSONIC transport planes
N1 - Accession Number: 12033695; Reynolds, Michael D. Draine, Bruce 1 Greenly, John 1 Garland, David 1 Pyenson, Lewis 1 Schwartz, Richard A. 2 Davison, Gerald C. 3; Affiliation: 1: Swarthmore College 2: Assistant Chief of Psychiatry, US Public Health Service Hospital, Staten Island, NY 3: State University of New York, Stony Brook, NY; Source Info: 2/18/67, Vol. 156 Issue 7, p34; Subject Term: LETTERS to the editor; Subject Term: WAR casualties -- Statistics; Subject Term: MENTALLY ill; Subject Term: CRIMINALS; Subject Term: SUPERSONIC transport planes; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hom, George L.
T1 - Short-Term Retention as a Function of Associative Strength and Retention Intervals.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1967/09//
VL - 34
IS - 1
M3 - Article
SP - 27
EP - 30
SN - 00144029
AB - The effects of association strength, retention intervals, and repetition of task on paired-associate acquisition by retardates were studied. 30 retardates with an MA range of 5.6 to 9.8 were divided randomly into 3 groups of 10 subjects each, corresponding to each of the retention intervals-zero seconds, 2 seconds, and 4 seconds delay of recall. 12 paired-associate pictures representing high, medium, and low association value were presented randomly to each subject. After each presentation, subjects were required to recall the response picture associated with each stimulus picture. The results showed that associative strength and retention intervals have a significant effect on mentally retarded children's retentive process. This study suggests that the factor of immediate feedback and the use of meaningful materials should play an important role in the educational curriculum and the teaching method with exceptional children. [ABSTRACT FROM AUTHOR]
AB - Copyright of Exceptional Children is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN with mental disabilities
KW - EXCEPTIONAL children
KW - MEMORY
KW - PSYCHOLOGY of learning
KW - COGNITIVE development
KW - CURRICULA (Courses of study)
KW - TEACHING methods
KW - DEVELOPMENTALLY disabled
KW - DEVELOPMENTAL disabilities
N1 - Accession Number: 19692894; Hom, George L. 1; Affiliation: 1: US Public Health Service Fellow, Department of Special Education, School of Education, University of Oregon, Eugene; Source Info: Sep1967, Vol. 34 Issue 1, p27; Subject Term: CHILDREN with mental disabilities; Subject Term: EXCEPTIONAL children; Subject Term: MEMORY; Subject Term: PSYCHOLOGY of learning; Subject Term: COGNITIVE development; Subject Term: CURRICULA (Courses of study); Subject Term: TEACHING methods; Subject Term: DEVELOPMENTALLY disabled; Subject Term: DEVELOPMENTAL disabilities; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nickols, John
T1 - EFFECTS OF GROUP PROJECTIVE TESTING ON RORSCHACH SCORES.
JO - Journal of Clinical Psychology
JF - Journal of Clinical Psychology
Y1 - 1967/10//
VL - 23
IS - 4
M3 - Article
SP - 497
EP - 497
PB - John Wiley & Sons, Inc.
SN - 00219762
AB - The article cites a study which attempts to determine whether self-administered projective tests could be used in mass screening situations without significantly altering the distribution of scores to be obtained during subsequent use of the individualized Rorschach test method. Self-administered tests included two Ancillary Projective (AP) Methods and a Group Rorschach (GR). The AP Method of Content requires participant to write down the one thing of which each of five unstructured pictures reminds him most. Wechsler Adult Intelligence Scale scores seemed to be a necessary matching variable, since they correlated significantly with all Rorschach scores studied.
KW - RORSCHACH Test
KW - PROJECTIVE techniques
KW - PICTURES
KW - WECHSLER Adult Intelligence Scale
KW - INTELLIGENCE tests
KW - PSYCHOLOGY
N1 - Accession Number: 15866037; Nickols, John 1; Affiliation: 1: Mental Health Services, U. S. Public Health Service Outpatient Clinic, Washington, D. C.; Source Info: Oct1967, Vol. 23 Issue 4, p497; Subject Term: RORSCHACH Test; Subject Term: PROJECTIVE techniques; Subject Term: PICTURES; Subject Term: WECHSLER Adult Intelligence Scale; Subject Term: INTELLIGENCE tests; Subject Term: PSYCHOLOGY; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowen, W. J.
AU - Evans Jr., T. C.
T1 - The Binding of ATP to Myosins B and A.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1968/09//
VL - 5
IS - 4
M3 - Article
SP - 507
EP - 512
PB - Wiley-Blackwell
SN - 00142956
AB - Values for binding of ATP and ADP to myosin B and ATP to myosin A were determined from mixtures of these nucleotides and proteins by use of rapid filtration to separate bound and unbound nucleotides and by use of an ATP-regenerating system (ereatine phosphatecreatine phosphokinase). Calculation of the binding curves of ATP to 105 g of myosin B by the mass law binding expression using two sets of binding sites, n1 and n2, and with binding constants, k1=40 × 103 and k2=1.5 × 103 1/mole, respectively, yielded a curve of good fit to the experimentally determined points when n1=0.4 and n2=1.2 moles per l05 g. Similar calculation of data from binding of ATP to myosin A fielded a curve of best fit when n1=0.5 and n2=3.0 per 105 g with k1=5,500 and k2=550 1/mole. At 1 mM ATP, myosin A bound 50% more than myosin B. ADP at 1 mM appeared to saturate myosin B about 97%. The amounts of ADP bound to myosin B fitted a curve with one value of n which equaled 0.36. Multiplication of 105 g by the factors required to convert the above n values to integers fields combining weights of 250,000 and 200,000 for myosin B and myosin A. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphate
KW - MYOSIN
KW - NUCLEOTIDES
KW - PROTEINS
KW - BIOCHEMISTRY
KW - CREATINE
N1 - Accession Number: 12791312; Bowen, W. J. 1,2 Evans Jr., T. C. 1,3; Affiliation: 1: National Institute of Arthritis and Metabolic Diseases National Institutes of Health, Public Health Service U.S. Department of Health, Education and Welfare Bethesda, Maryland 2: Bldg. 4, Room B1-06 Lab. Biophysical Chemistry National Institutes of Health, National Institute of Artritis and Metabolic Diseases, Bethesda, Maryland 20014, U.S.A. 3: Mayo Clinic, Rochester, Minnesota, 55901, U.S.A.; Source Info: 1968, Vol. 5 Issue 4, p507; Subject Term: ADENOSINE triphosphate; Subject Term: MYOSIN; Subject Term: NUCLEOTIDES; Subject Term: PROTEINS; Subject Term: BIOCHEMISTRY; Subject Term: CREATINE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Natkin, Eugene
AU - Van Hassel, Henry J.
AU - Steiner, James C.
T1 - The Comparative Merits of Silver Cones and Gutta Percha in the treatment of Fine Canals of Molar Teeth.
JO - Journal of the British Endodontic Society
JF - Journal of the British Endodontic Society
Y1 - 1969/10//Oct-Dec1969
VL - 3
IS - 4
M3 - Article
SP - 59
EP - 61
SN - 00070653
AB - Looks into the advantages of the use of gutta percha for obturation of the fine canals of molar teeth. Ability of gutta percha to adequately obturate an irregularly shaped canal; Detection of failures of gutta percha cases; Comparison of the effectiveness of gutta percha with a silver cone in obturating fine canals.
KW - FILLINGS (Dentistry)
KW - GUTTA-percha
KW - TEETH
KW - CYCLIZED rubber
KW - DENTAL pulp cavity
KW - OPERATIVE dentistry
N1 - Accession Number: 17610438; Natkin, Eugene 1 Van Hassel, Henry J. 2,3 Steiner, James C. 3; Affiliation: 1: Associate Professor and Chairman, Department of Endodontics, University of Washington, School of Dentistry, Seattle 2: Associate Chief, Dental Service for Research Federal Health Programmes Service, U.S. Public Health Service Hospital, Seattle 3: Assistant Professor, Department of Endodontics, University of Washington School of Dentistry; Source Info: Oct-Dec1969, Vol. 3 Issue 4, p59; Subject Term: FILLINGS (Dentistry); Subject Term: GUTTA-percha; Subject Term: TEETH; Subject Term: CYCLIZED rubber; Subject Term: DENTAL pulp cavity; Subject Term: OPERATIVE dentistry; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
T1 - The Immune Response in the Hamster II. STUDIES ON IgM.
JO - Immunology
JF - Immunology
Y1 - 1970/02//
VL - 18
IS - 2
M3 - Article
SP - 223
EP - 236
PB - Wiley-Blackwell
SN - 00192805
AB - Hamster IgM has been isolated and characterized. The protein possessed unique antigenic determinants but also shared common determinants with the 7Sγ1- and 7Sγ2-globulin classes. These shared determinants were present on the F(ab')2 and Fab fragments of 7Sγ2-globulin. The rapidly sedimenting (S20,w = 20.7) IgM was dissociated into slowly sedimenting (≈ 7S) units after reduction and alkylation. Specific antibody formation in the IgM and IgG (7Sγ1-globulin) classes appeared at similar times after immunization with protein antigens, although IgM antibody was only detectable for a short period. After immunization with antigen in Freund's adjuvant, the serum concentration of IgM increased and remained at an elevated level even after disappearance of antibody to the immunizing antigen. Injection of adjuvant alone also increased the concentration of serum IgM, particularly after intraperitoneal administration of Freund's incomplete adjuvant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN M
KW - IMMUNE response
KW - ANTIGENIC determinants
KW - HAMSTERS
KW - IMMUNOGLOBULINS
KW - IMMUNOLOGICAL adjuvants
N1 - Accession Number: 13358132; Coe, J.E. 1; Affiliation: 1: United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Feb70, Vol. 18 Issue 2, p223; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNE response; Subject Term: ANTIGENIC determinants; Subject Term: HAMSTERS; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOLOGICAL adjuvants; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Francis, T. C.
AU - Oppenheim, J. J.
T1 - IMPAIRED LYMPHOCYTE STIMULATION BY SOME STREPTOCOCCAL ANTIGENS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS AND RHEUMATIC HEART DISEASE.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1970/04//
VL - 6
IS - 4
M3 - Article
SP - 573
EP - 586
PB - Wiley-Blackwell
SN - 00099104
AB - The effects of pathogenic and non-pathogenic streptococci, streptococcal cell wall products, and phytohaemagglutinin on human peripheral leucocyte cultures from four groups were studied. These groups were; (1) normals, (2) patients with aphthous stomatitis, (3) patients with Behçet's disease, and (4) patients with rheumatic heart disease. The degree of lymphocyte stimulation by these materials was measured by uptake of [3H]thymidine into DNA in vitro. In normals, patients with aphthous stomatitis, and Behçet's disease, the human pathogenic group A streptococci produced significantly greater stimulation of DNA synthesis than did the less pathogenic non-haemolytic streptococci. Lymphocytes from patients with aphthous stomatitis showed significantly less stimulation of DNA synthesis than comparable normal controls when exposed to heat-killed Streptococcal 2A, organisms which have been implicated in the disease. Human pathogenic strains of group A streptococci which have been implicated in rheumatic heart disease stimulated. significantly less in vitro proliferation of lymphocytes froth patients with rheumatic heart disease than of those from a comparable group of normal controls. This hypo-responsiveness persisted when the patients' lymphocytes were cultured in normal human serum. The chronically ill Behçet's patients' lymphocytes did not differ significantly from normal. These observations indicate a deficiency of the cellular response of certain patients to antigens from organisms thought to be aetiologically related to their disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - STREPTOCOCCUS
KW - STOMATITIS
KW - ORAL diseases
KW - CARDIOLOGY
KW - BLOOD plasma
KW - LEUCOCYTES
N1 - Accession Number: 14587216; Francis, T. C. 1 Oppenheim, J. J. 1; Affiliation: 1: Oral Medicine and Surgery Branch, and Cell Biology Section, United States Department of Health, Education and Welfare, Public Health Service, National Institute of Dental Research, Bethesda, Maryland.; Source Info: Apr70, Vol. 6 Issue 4, p573; Subject Term: LYMPHOCYTES; Subject Term: STREPTOCOCCUS; Subject Term: STOMATITIS; Subject Term: ORAL diseases; Subject Term: CARDIOLOGY; Subject Term: BLOOD plasma; Subject Term: LEUCOCYTES; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Damm, Vernon J.
T1 - Creativity and Intelligence: Research Implications for Equal Emphasis in High School.
JO - Exceptional Children
JF - Exceptional Children
Y1 - 1970/04//
VL - 36
IS - 8
M3 - Article
SP - 565
EP - 569
SN - 00144029
AB - The possible relationships among creativity, intelligence, and self actualization were examined in 208 high school students to determine whether or not consistent self actualization scores existed for subjects high in the first two variables. Students high in both creativity and intelligence had significantly higher scores in self actualization than those obtained by students high in either creativity or intelligence. No significant difference in self actualization was found between students high in creativity only and those high in intelligence only. The results were interpreted as indicating that educational systems should stress both intellectual and creative abilities to achieve the highest level of psychological well being in students. [ABSTRACT FROM AUTHOR]
AB - Copyright of Exceptional Children is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CREATIVE ability
KW - INTELLECT
KW - SELF-actualization (Psychology)
KW - HIGH school students -- Attitudes
KW - HIGH school students
KW - HIGH schools
KW - EDUCATION
KW - EDUCATION -- Research
KW - EDUCATIONAL surveys
N1 - Accession Number: 19708404; Damm, Vernon J. 1; Affiliation: 1: Project Director, US Public Health Service Grant for Curriculum Development, School of Nursing, University of Portland, Oregon; Source Info: Apr1970, Vol. 36 Issue 8, p565; Subject Term: CREATIVE ability; Subject Term: INTELLECT; Subject Term: SELF-actualization (Psychology); Subject Term: HIGH school students -- Attitudes; Subject Term: HIGH school students; Subject Term: HIGH schools; Subject Term: EDUCATION; Subject Term: EDUCATION -- Research; Subject Term: EDUCATIONAL surveys; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
AU - Peel, L. F.
T1 - Antibody Production in the Bullfrog (Rana catesbeiana .
JO - Immunology
JF - Immunology
Y1 - 1970/10//
VL - 19
IS - 4
M3 - Article
SP - 539
EP - 550
PB - Wiley-Blackwell
SN - 00192805
AB - Serum antibody was found by radioimmunoelectrophoresis (RIEP) in thirty-one of thirty-five bullfrogs (BF) immunized with one of four protein antigens. Rabbit γ globulin (RGG) and hen egg albumin were the best antigens, whereas human serum albumin and bovine serum albumin induced a less consistent immune response. Although a IgM to IgG sequence of antibody production usually was detected with RGG as antigen, a similar sequence was infrequent with the other antigens and the initial response was usually a IgG antibody. IgM antibody was detected in the serum for a prolonged interval (>100 days) and precipitating quantities of IgG antibody were found more than 1 year after antigen inoculation. As measured by haemagglutination, the IgM antibody was routinely inactivated by mercaptoethanol (ME) treatment and IgG antibody was frequently inactivated by ME, although it still had antigen binding capacity by RIEP. IgG hemagglutinins, which were resistant to ME treatment, were found in some sera obtained from BF after booster injections of antigen. Immunoelectrophoretic examination of normal or immune BF sera revealed a prominent precipitin line of slow γ-mobility which did not bind 131I-labelled antigen but did bind 59Fe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - BULLFROG
KW - ANTIGENS
KW - PRECIPITIN reaction
KW - IMMUNITY
KW - ADMINISTRATION of drugs
N1 - Accession Number: 13360207; Coe, J.E. 1 Peel, L. F. 1; Affiliation: 1: United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Oct70, Vol. 19 Issue 4, p539; Subject Term: IMMUNOGLOBULINS; Subject Term: BULLFROG; Subject Term: ANTIGENS; Subject Term: PRECIPITIN reaction; Subject Term: IMMUNITY; Subject Term: ADMINISTRATION of drugs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Summerlin, William T.
AU - Charlton, Ellen
AU - Karasek, Marvin
T1 - TRANSPLANTATION OF ORGAN CULTURES OF ADULT HUMAN SKIN.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1970/11//
VL - 55
IS - 5
M3 - Article
SP - 310
EP - 316
SN - 0022202X
AB - Under standard tissue culture growth conditions, both split-thickness and full-thickness skin explants remain viable for up to 6 weeks in organ culture. During this period the epidermis becomes thin, and the basement membrane thickens. The content of elastin in the dermis decreases. Epiboly is complete by the 2nd to the 4th week in culture. When transplanted to a full-thickness wound site the epidermal architecture returns to normal. Dermal elastin is, however, not resynthesized. No evidence for an abnormal growth of cells in either the dermis or the epidermis has been detected in follow-up studies of the grafted skin over a one and one-half year interval. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - ORGAN culture
KW - SKIN
KW - EPIDERMIS
KW - CELLULAR growth
KW - ELASTIN
KW - BASAL lamina
N1 - Accession Number: 12260178; Summerlin, William T. 1,2 Charlton, Ellen 2 Karasek, Marvin 2; Affiliation: 1: Teaching and Training Fellow, U. S. Public Health Service, Grant AM 53108 2: Department of Dermatology, Stanford University School of Medicine, Stanford, California, 94305; Source Info: Nov70, Vol. 55 Issue 5, p310; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: ORGAN culture; Subject Term: SKIN; Subject Term: EPIDERMIS; Subject Term: CELLULAR growth; Subject Term: ELASTIN; Subject Term: BASAL lamina; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260178
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, Choong W.
AU - Giles, Albert L.
AU - Carson, Theophilus R.
T1 - INDUCTION OF DELAYED HYPERSENSITIVITY IN GUINEA PIGS BY AFLATOXINS, OTHER COUMARINS AND FURAZOLIUM.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1970/12//
VL - 55
IS - 6
M3 - Article
SP - 396
EP - 403
SN - 0022202X
AB - Aflatoxins B1, B2, G1 and G2, highly toxic mycological metabolic products occurring as food contaminants, were capable in minute quantities of causing delayed hypersensitivity in guinea pigs. Structurally related compounds, sterigmatocystin (a mycotoxin), coumarin, 8-methoxypsoralen and furazolium chloride were also equally or more active in causing delayed hypersensitivity in guinea pigs. Animals which were strongly sensitized to aflatoxin B1 showed cross-reactivity to other aflatoxins (B2, G1 and G2), sterigmatocystin, coumarins, 8-methoxypsoralen, furans and commerical perfumes. Less strongly immunized animals, on the other hand, showed differential cross-reactivity in that other aflatoxins produced frank erythema whereas closely related compounds were more moderate in action. None of these immunized animals showed any circulating antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - GUINEA pigs
KW - AFLATOXINS
KW - COUMARINS
KW - MYCOTOXINS
KW - PERFUMES
N1 - Accession Number: 12260504; Chung, Choong W. 1 Giles, Albert L. 1 Carson, Theophilus R. 1; Affiliation: 1: Division of Toxicology, Bureau of Foods and Pesticides, Food and Drug Administration, U.S. Department of Health, Education and Welfare, Washington, D.C. 20204.; Source Info: Dec70, Vol. 55 Issue 6, p396; Subject Term: ALLERGY; Subject Term: GUINEA pigs; Subject Term: AFLATOXINS; Subject Term: COUMARINS; Subject Term: MYCOTOXINS; Subject Term: PERFUMES; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12260504
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jacqueline J.
AU - Burke, Allyn D.
T1 - The effectiveness of the Charters', scrub and roll methods of toothbrushing by professionals in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1970/12//
VL - 78
IS - 7
M3 - Article
SP - 459
EP - 463
SN - 0029845X
AB - The effectiveness of the Charters' , scrub, and roll methods of toothbrushing by professional dental personnel in removing plaque was studied in 60 United States Army recruits. An interaction between method of brushing and brusher was found, indicating that no one method was clearly most effective in removing plaque. One brusher removed significantly more plaque with the Charters' method than with the roll method, whereas the other brusher obtained a significantly greater reduction in plaque with the scrub method than with either the Charters' or the roll methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL plaque
KW - DENTAL deposits
KW - DENTAL personnel -- United States
KW - MEDICAL personnel
KW - UNITED States
N1 - Accession Number: 16615062; Frandsen, Asger M. 1 Barbano, Joseph P. 2 Suomi, John D. 2 Chang, Jacqueline J. 2 Burke, Allyn D. 3; Affiliation: 1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark 2: Division of Dental Health, Bureau of Health Professions Education and Manpower Training, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland 3: U.S. Army Dental Corps, Fort Ord, California, U.S.A; Source Info: 1970, Vol. 78 Issue 7, p459; Subject Term: DENTAL plaque; Subject Term: DENTAL deposits; Subject Term: DENTAL personnel -- United States; Subject Term: MEDICAL personnel; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawson, C. L.
AU - Slagle, James R.
AU - Farrell, Carl D.
T1 - Experiments in Automatic Learning for a Multipurpose Heuristic Program.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 91
EP - 99
SN - 00010782
AB - An automatic learning capability has been developed and implemented for use with the MULTIPLE (MULTIpurpose Program that LEarns) heuristic tree-searching program, which is presently being applied to resolution theorem-proving in predicate calculus. MULTIPLE's proving program (PP) uses two evaluation functions to guide its search for a proof of whether or not a particular goal is achievable. Thirteen general features of predicate calculus clauses were created for use in the automatic learning of better evaluation functions for PP. A multiple regression program was used to produce optimal coefficients for linear polynomial functions in terms of the features. Also, automatic data-handling routines were written for passing data between the learning program and the proving program, and for analyzing and summarizing results. Data was generally collected for learning (regression analysis) from the experience of PP. A number of experiments were performed to test the effectiveness and generality of the learning program. Results showed that the learning produced dramatic improvements in the solutions to problems which were in the same domain as those used for collecting learning data. Learning was also shown to generalize successfully to domains other than those used for data collection. Another experiment demonstrated that the learning program could simultaneously improve performance on problems in a specific domain and on problems in a variety of domains. Some variations of the learning program were also tested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER programming
KW - CALCULUS -- Software
KW - MATHEMATICAL analysis
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - MULTIVARIATE analysis
KW - adaptive
KW - artificial intelligence
KW - automatic learning
KW - heuristic
KW - learning
KW - LISP
KW - multiple regression
KW - problem-solving
KW - resolution
KW - self-modifying
KW - theorem-providing
KW - tree-searching
N1 - Accession Number: 5221545; Lawson, C. L. Slagle, James R. 1 Farrell, Carl D. 2; Affiliation: 1: Stanford Artificial Intelligence Project, Stanford University, Stanford, California. 2: Division of Computer Research and Technology, National Institutes of Health, Public Health Service.; Source Info: Feb1971, Vol. 14 Issue 2, p91; Subject Term: COMPUTER programming; Subject Term: CALCULUS -- Software; Subject Term: MATHEMATICAL analysis; Subject Term: REGRESSION analysis; Subject Term: MATHEMATICAL statistics; Subject Term: MULTIVARIATE analysis; Author-Supplied Keyword: adaptive; Author-Supplied Keyword: artificial intelligence; Author-Supplied Keyword: automatic learning; Author-Supplied Keyword: heuristic; Author-Supplied Keyword: learning; Author-Supplied Keyword: LISP; Author-Supplied Keyword: multiple regression; Author-Supplied Keyword: problem-solving; Author-Supplied Keyword: resolution; Author-Supplied Keyword: self-modifying; Author-Supplied Keyword: theorem-providing; Author-Supplied Keyword: tree-searching; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 9p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slagle, James R.
AU - Lee, Richard C. T.
T1 - Application of Game Tree Searching Techniques to Sequential Pattern Recognition.
JO - Communications of the ACM
JF - Communications of the ACM
Y1 - 1971/02//
VL - 14
IS - 2
M3 - Article
SP - 103
EP - 110
SN - 00010782
AB - A sequential pattern recognition (SPR) procedure does not test all the features of a pattern at once. Instead, it selects a feature to be tested. After receiving the result of that test, the procedure either classifies the unknown pattern or selects another feature to be tasted, etc. Medical diagnosis is an example of SPR. In this paper the authors suggest that SPR be viewed as a one-person game played against nature (chance). Virtually all the powerful techniques developed for searching two-person, strictly competitive game trees can easily be incorporated either directly or by analogy into SPR procedures. In particular, one can incorporate the "miniaverage backing-up procedure" and the "gamma procedure," which are the analogues of the minimax backing-up procedure and the alpha-beta procedure," respectively. Some computer simulated experiments in character recognition ore presented. The results indicate that the approach is promising. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications of the ACM is the property of Association for Computing Machinery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRONIC data processing
KW - COMPUTER software
KW - COMPUTERS in education
KW - COMPUTER programming
KW - INTEGRAL equations
KW - SEQUENTIAL processing (Computer science)
KW - branch-and-bound approach
KW - dynamic programming
KW - game against nature
KW - game tree searching
KW - gamma procedure
KW - miniaverage backing-up procedure
KW - optimal solution
KW - sequential pattern recognition
N1 - Accession Number: 5221547; Slagle, James R. 1 Lee, Richard C. T. 1; Affiliation: 1: Department of health, Education and Welfare, Division of Computer Research and Technology, Public Health Service. National Institutes of Health, Bethesda, Maryland.; Source Info: Feb1971, Vol. 14 Issue 2, p103; Subject Term: ELECTRONIC data processing; Subject Term: COMPUTER software; Subject Term: COMPUTERS in education; Subject Term: COMPUTER programming; Subject Term: INTEGRAL equations; Subject Term: SEQUENTIAL processing (Computer science); Author-Supplied Keyword: branch-and-bound approach; Author-Supplied Keyword: dynamic programming; Author-Supplied Keyword: game against nature; Author-Supplied Keyword: game tree searching; Author-Supplied Keyword: gamma procedure; Author-Supplied Keyword: miniaverage backing-up procedure; Author-Supplied Keyword: optimal solution; Author-Supplied Keyword: sequential pattern recognition; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 541519 Other Computer Related Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; Number of Pages: 8p; Illustrations: 13 Diagrams; Document Type: Article
L3 - 10.1145/362515.362562
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J. B.
T1 - The Immune Response in the Hamster III. SELECTIVE INDUCTION OF CONCOMITANT ANTIBODY FORMATION AND UNRESPONSIVENESS IN THE 7Sγ1- AND 7Sγ2-GLOBULINS WITH SOLUBLE HEN EGG ALBUMIN.
JO - Immunology
JF - Immunology
Y1 - 1971/08//
VL - 21
IS - 2
M3 - Article
SP - 175
EP - 191
PB - Wiley-Blackwell
SN - 00192805
AB - Synthesis of antibody to hen egg albumin (HEA) was restricted to one of the 7S immunoglobulins (7Sγ1:globulin) when hamsters were inoculated with soluble HEA (HEA-saline). This selective induction occurred regardless of the amount of HEA-saline injected (0.001–5·0 mg) or the route of inoculation. In contrast, HEA in Freund's adjuvants induced synthesis of anti-HEA in both the 7Sγ1 - and 7Sγ2 -globulins, even when as little as 0.1 μg of HEA was used. Repeated inoculations of hamsters with HEA-saline increased or maintained 7Sγ1 antibody, but did not induce anti-HEA synthesis in the 7Sγ2 -globulins. The results of cell transfer experiments indicated that cells from HEA-saline treated hamsters were primed to synthesize 7Sγ1 anti-HEA and were specifically unresponsive for 7Sγ2 anti-HEA synthesis. Selective induction of antibody production and unresponsiveness, concomitantly, within different immunoglobulin classes suggests that different antibody induction mechanisms are utilized by these two immunoglobulin classes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINS
KW - IMMUNOGLOBULINS
KW - HAMSTERS
KW - IMMUNE response
KW - ANTIGENS
N1 - Accession Number: 13480522; Coe, J. B. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Aug71, Vol. 21 Issue 2, p175; Subject Term: ALBUMINS; Subject Term: IMMUNOGLOBULINS; Subject Term: HAMSTERS; Subject Term: IMMUNE response; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wegesa, P.
AU - Sulzer, A.J.
AU - Van Orden, Avis
T1 - A Slide Antigen in the Indirect Fluorescent Antibody Test for Trichinella spiralis .
JO - Immunology
JF - Immunology
Y1 - 1971/11//
VL - 21
IS - 5
M3 - Article
SP - 805
EP - 808
PB - Wiley-Blackwell
SN - 00192805
AB - A stable cuticular slide antigen was prepared for use in the indirect fluorescent antibody (IFA) test for trichinosis. Cuticles of Trichinella spiralis larvae, prepared by pepsin digestion, were embedded in Tissue-Tek OCT embedding medium, frozen, and sections made and mounted on slides. After storage at -70° for 2 days to allow the antigen sections to become firmly affixed to the slides, they may be used to perform the IFA test for trichinosis. This method is less timeconsuming, due to the elimination of centrifugation steps, than the antigen presently in use for the trichinosis IFA test, and should be applicable to other IFA procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - FLUORESCENT antibody technique
KW - IMMUNOGLOBULINS
KW - TRICHINELLA spiralis
KW - PEPSIN
KW - LARVAE
N1 - Accession Number: 14050297; Wegesa, P. 1 Sulzer, A.J. 2 Van Orden, Avis 2; Affiliation: 1: East African Institute of Malaria and Vector-Borne Diseases, Amani, Tanzania 2: Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, Georgia 30333, U.S.A.; Source Info: Nov71, Vol. 21 Issue 5, p805; Subject Term: ANTIGENS; Subject Term: FLUORESCENT antibody technique; Subject Term: IMMUNOGLOBULINS; Subject Term: TRICHINELLA spiralis; Subject Term: PEPSIN; Subject Term: LARVAE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J. E.
T1 - Studies on IgA of the Guinea-Pig.
JO - Immunology
JF - Immunology
Y1 - 1972/03//
VL - 22
IS - 3
M3 - Article
SP - 333
EP - 345
PB - Wiley-Blackwell
SN - 00192805
AB - The secretory immunoglobulin of the guinea-pig, IgA, was antigenically unique when compared with the 7Sγ1-, 7Sγ2- and γM-globulins, although it did share Fab determinants in common with the 7S&gamma2 globulin. Specific antigen binding capacity was detected in serum IgA after sequential oral and parenteral sensitization with purified protein antigens. IgA was prominent in saliva and succus entericus; in colostrum its concentration was 4–8 times that in normal serum. IgA in serum and secretory fluids sedimented at similar rates (≈12S), although colostral IgA contained an additional ≈16S population. Serum and secretory IgA appeared antigenically identical, however, serum IgA was especially sensitive to mild reductive procedures and became ≈7S after treatment. Serum IgA migrated as a β-protein on electrophoresis and was faster than IgA of colostrum. Antisera to IgA were produced by a procedure which involved simple precipitation of secretory IgA with an antiserum containing antibodies to common determinants of guinea-pig Ig. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - IMMUNOGLOBULINS
KW - PROTEINS
KW - SPUTUM
KW - COLOSTRUM
KW - IMMUNE serums
N1 - Accession Number: 14514637; Coe, J. E. 1; Affiliation: 1: U.S. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Mar72, Vol. 22 Issue 3, p333; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEINS; Subject Term: SPUTUM; Subject Term: COLOSTRUM; Subject Term: IMMUNE serums; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chandler Jr., Francis W.
AU - Kaufmann, Arnold F.
AU - Kuhn III, U. S. G.
T1 - THE HISTOPATHOLOGY OF EXPERIMENTAL PINTA IN THE CHIMPANZEE.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1972/03//
VL - 58
IS - 3
M3 - Article
SP - 103
EP - 108
SN - 0022202X
AB - Pinta lesions in various stages of development from experimentally infected chimpanzees were subjected to histopathologic examination. Both early lesions and lesions of long duration were strikingly similar to the corresponding lesions in man. However, observed differences in the chimpanzee lesions included the demonstration of Treponema carateum in the upper dermis, a location in which they are rarely found in man. The endstage of chimpanzee pinta was hyperpigmentation or normal pigmentation of the affected area as opposed to irreversible hypopigmentation more commonly seen in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PINTA
KW - CHIMPANZEES
KW - PRECANCEROUS conditions
KW - PATHOLOGICAL histology
KW - TREPONEMA
KW - PIGMENTATION disorders
N1 - Accession Number: 12538894; Chandler Jr., Francis W. 1 Kaufmann, Arnold F. 2 Kuhn III, U. S. G. 1; Affiliation: 1: Venereal Disease Research Laboratory, Venereal Disease Program, State and Community Services Division, Center for Disease Control, Health Services, and Mental Health Administration, Public Health Service, U.S. Department of Health, Atlanta, GA 30333 2: Chief Bacterial Zooneses Section, Bacterial Diseases Branch, Epidemiology Program, CDC, HSMHA, PHS, HEW.; Source Info: Mar72, Vol. 58 Issue 3, p103; Subject Term: PINTA; Subject Term: CHIMPANZEES; Subject Term: PRECANCEROUS conditions; Subject Term: PATHOLOGICAL histology; Subject Term: TREPONEMA; Subject Term: PIGMENTATION disorders; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12538894
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peters, C. J.
AU - Johnson, K. M.
T1 - SERUM IMMUNOGLOBULIN LEVELS IN AUSTRALIA ANTIGEN POSITIVE AND AUSTRALIA ANTIGEN NEGATIVE HEPATITIS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1972/07//
VL - 11
IS - 3
M3 - Article
SP - 381
EP - 391
PB - Wiley-Blackwell
SN - 00099104
AB - Ig levels were determined by radial immunodiffusion in uncomplicated cases of acute hepatitis with or without Australia antigenaemia. Initial sera from Australia antigen negative cases showed a striking elevation in IgM levels when compared to Australia antigen positive cases (6.5 versus 1.9 mg/ml). None of twenty-four Australia antigen positive cases exceeded 3 mg/ml IgM, and only 3/58 Australia antigen negative cases exhibited values below 3 mg/ml. initial sera from Australia antigen positive and Australia antigen negative subjects did not differ in concentration of IgG, IgA, or IgD. Serial determinations of IgG revealed a transient fall in patients with Australia antigen positive hepatitis, and a rise in Australia antigen negative cases. Asymptomatic, Australia antigen positive, Guaymi Indian subjects were compared to matched Australia antigen negative controls from the same indigenous group and no differences in the concentration of IgG, IgM, IgA or IgD were found, although elevations of IgG and IgM were common in both groups. No evidence of abnormal proteins was found when sera were tested by cellulose acetate electrophoresis or by immunoelectrophoresis versus immunoglobulin-specific anti- sera. Ultracentrifugal analysis failed to detect `7S' IgM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNODIFFUSION
KW - ANTIGENS
KW - IMMUNOGLOBULIN G
KW - ANTIGEN-antibody reactions
KW - IMMUNOELECTROPHORESIS
KW - ELECTROPHORESIS
N1 - Accession Number: 14545001; Peters, C. J. 1 Johnson, K. M. 1; Affiliation: 1: U.S. Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Middle America Research Unit, Box 2011, Balboa Heights, Canal Zone, Central America.; Source Info: Jul72, Vol. 11 Issue 3, p381; Subject Term: IMMUNODIFFUSION; Subject Term: ANTIGENS; Subject Term: IMMUNOGLOBULIN G; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOELECTROPHORESIS; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
T1 - Immune Response in the Turtle (Chrysemys picta ).
JO - Immunology
JF - Immunology
Y1 - 1972/07//
VL - 23
IS - 1
M3 - Article
SP - 45
EP - 52
PB - Wiley-Blackwell
SN - 00192805
AB - The immune response of painted turtles (Chrysemys picta) to four purified protein antigens was evaluated by radioimmunoelectrophoresis. Specific antibody production was consistently detected and antigen binding was related to four immunoglobulin (Ig) precipitin lines (called Igl, 2, 3, 4) in turtle serum. Antibody activity was detected first in the Ig1 or Ig2 and then later in the course of immunization in Ig3 and Ig4. Igl was about 19S in size, was not detectable after reduction and alkylation, and was the only Ig absent from turtle lymph. Ig3 and Ig4 were about 7S in size and Ig2 appeared slightly heavier by sucrose density gradient and Sephadex G-200 analysis. Haemagglutinins produced after primary inoculation were routinely sensitive to mild reduction and alkylation although antigen-binding capacity was still detectable. However, mercaptoethanol-resistant haemagglutinins were found in sera from turtles after booster injections of antigen. The electrophoretically slowest gamma globulin in turtle serum did not develop specific antigen binding capacity, but did bind Fe59 and presumably represents a transferrin-like protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - IMMUNOLOGY
KW - CHRYSEMYS
KW - TURTLES
KW - ANTIGEN-antibody reactions
KW - IMMUNOGLOBULINS
KW - HEMAGGLUTININ
N1 - Accession Number: 13378221; Coe, J.E. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840, U.S.A.; Source Info: Jul72, Vol. 23 Issue 1, p45; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: CHRYSEMYS; Subject Term: TURTLES; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNOGLOBULINS; Subject Term: HEMAGGLUTININ; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Frandsen, Asger M.
AU - Barbano, Joseph P.
AU - Suomi, John D.
AU - Chang, Jaqueline J.
AU - Houston, Robert
T1 - A comparison of the effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/07//
VL - 80
IS - 4
M3 - Article
SP - 267
EP - 271
SN - 0029845X
AB - The effectiveness of the CHARTERS', scrub, and roll methods of toothbrushing in removing plaque was studied in 182 college students. At an initial screening examination, plaque was assessed using the gingival index. These plaque scores were used to divide the group into those with poor and those with good oral cleanliness. Within each of the two groups, the subjects were randomly assigned to a toothbrushing method and to one of three instructors. Then the participants had their teeth cleaned and were asked to abstain from toothbrushing for one week. After this period of plaque accumulation the participants were again scored for plaque. The test subjects were carefully instructed in the particular tooth-brushing method they were to use and the controls were asked to resume their usual methods. One week later the participants were again examined for plaque. An interaction between toothbrushing method and instructor was found indicating that the effectiveness of a particular method depended in pan on. the instructor. Nevertheless, the CHARTERS' and scrub methods of brushing appeared to be more effective in removing plaque. Generally, subjects with cleaner teeth prior to the stu achieved grater plaque reductions than those with initially poor oral cleanliness. All methods of bruching were relatively ineffective in removing proximal plaque. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOOTHBRUSHES
KW - DENTAL plaque
KW - ORAL hygiene products
KW - DENTAL deposits
KW - GINGIVAL fluid
KW - DENTAL care
N1 - Accession Number: 13235069; Frandsen, Asger M. 1 Barbano, Joseph P. 2 Suomi, John D. 2 Chang, Jaqueline J. 2 Houston, Robert 3; Affiliation: 1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark. 2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland and San Francisco, California. 3: Department ot Health, Oregon State University, Corvallis, Oregon, U.S.A.; Source Info: 1972, Vol. 80 Issue 4, p267; Subject Term: TOOTHBRUSHES; Subject Term: DENTAL plaque; Subject Term: ORAL hygiene products; Subject Term: DENTAL deposits; Subject Term: GINGIVAL fluid; Subject Term: DENTAL care; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 339994 Broom, Brush, and Mop Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frandsen, A. M
AU - MacClendon, B. J.
AU - Chang, J. J.
AU - Creighton, W. E.
T1 - The effect of oral rinsing with sodium fluoride on the gingiva of children.
JO - Scandinavian Journal of Dental Research
JF - Scandinavian Journal of Dental Research
Y1 - 1972/09//
VL - 80
IS - 5
M3 - Article
SP - 445
EP - 448
SN - 0029845X
AB - The effect of a weekly mouthrinsing with a 0.2 % sodium fluoride solution on the gingiva of children was investigated using a double-blind technique. One hundred and twenty-seven Grade 2 children (6-7 years old) and 126 Grade 6 children (12-13 years old) of Negro and Caucasian background formed the study groups. In each age group, fluoride and placebo subgroups were formed which were balanced as to sex, race and number. Assessments were made for the presence of gingival inflammation, plaque and calculus on six selected permanent teeth. The results indicated that in neither age group was the degree of gingivitis influenced by the fluoride mouthrinse. Further, no differences between the two age groups in degree of gingivitis and amount of plaque were noted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Dental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUMS
KW - PERIODONTIUM
KW - SODIUM fluoride
KW - FLUORIDES
KW - CHILDREN
KW - MOUTH
KW - PERIODONTICS
N1 - Accession Number: 13238240; Frandsen, A. M 1 MacClendon, B. J. 2,3 Chang, J. J. 2,3 Creighton, W. E. 4; Affiliation: 1: Department of Periodontology, Royal Dental College, Copenhagen, Denmark 2: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland, U.S.A. 3: Division of Dental Health, Bureau of Health Manpower Education, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and WelfareSan Francisco, California, U.S.A. 4: Division of Public Health, Multnomah County, Oregon, U.S A.; Source Info: 1972, Vol. 80 Issue 5, p445; Subject Term: GUMS; Subject Term: PERIODONTIUM; Subject Term: SODIUM fluoride; Subject Term: FLUORIDES; Subject Term: CHILDREN; Subject Term: MOUTH; Subject Term: PERIODONTICS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Millar, David B.
AU - Grafius, Melba A.
AU - Palmer, David A.
AU - Millar, Geraldine
T1 - Enzymatically Active Half-Monomers of Acetyleholiesterase.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1973/08/15/
VL - 37
IS - 3
M3 - Article
SP - 425
EP - 433
PB - Wiley-Blackwell
SN - 00142956
AB - An enzymatically active 7.4-S species of acetylcholinesterase has been isolated which has a molecular weight of 134000 ± 6%. It apparently has its origin in a Triton-X-100-mediated cleavage of higher polymers of acetylcholinesterase but not from cleavage of purified 10.8-S enzyme. The half-monomer has a Km for acetylthiocholine almost twice that of 10.8-S enzyme but the K1 for eserine is the same. The subunit molecular weight of the 7.4-S enzyme, as determined by sodium dodecylsulfate gel electrophoresis, is about 65000 indicating the enzyme to be a dimer. The enzyme is maximally heat stable in 0.1 M ammonium sulfate. Under certain conditions we observe a speed dependency of the sedimentation coefficient. These properties may make the half-monomer a useful model for studying the kinetics and subunit interactions in acetylcholinesterase. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETYLCHOLINESTERASE
KW - CHOLINESTERASES
KW - ENZYMES
KW - PROTEINS
KW - POLYMERS
KW - MONOMERS
N1 - Accession Number: 13656713; Millar, David B. 1 Grafius, Melba A. 1 Palmer, David A. 1 Millar, Geraldine 2; Affiliation: 1: Laboratory of Physical Biochemistry, National Naval Medical Center, Bethesda, Maryland 2: Bureau of Drugs, Food and Drug Administration, Rocksville, Maryland; Source Info: 1973, Vol. 37 Issue 3, p425; Subject Term: ACETYLCHOLINESTERASE; Subject Term: CHOLINESTERASES; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: POLYMERS; Subject Term: MONOMERS; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barmes, David E.
AU - Cohen, Lois K.
T1 - Current status of WHO/DDH International Collaborative Study of Dental Manpower in Relation to Oral Health Status.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1974/04//
VL - 2
IS - 2
M3 - Article
SP - 37
EP - 39
SN - 03015661
AB - The International Collaborative Study of Dental Manpower Systems in Relation to Oral Health Status is being performed by the World Health Organization in collaboration with the United States Department of Health, Education and Welfare, and is funded under a contract from that Department. Data collection comprising clinical, attitudinal and behavioral material was completed in Australia, Norway, New Zealand and the Federal Republic of Germany in 1973. The data collection for 1974 in Japan and Bulgaria remains to be performed. An analysis of the contributions of various manpower and system factors in relation to the effectiveness and efficiency of oral health care delivery should be complete in the first half of 1975. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - WORLD health
KW - HEALTH surveys
KW - NORWAY
KW - AUSTRALIA
KW - dental health survey
KW - dental manpower
KW - epidemiology
KW - oral
KW - WORLD Health Organization
N1 - Accession Number: 17139089; Barmes, David E. 1 Cohen, Lois K. 2; Affiliation: 1: Dental Unit, World Health Organization, Geneva, Switzerland. 2: Division of Dentistry, Bureau of Health Resources Development, Health Resources Administration, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland, U. S. A.; Source Info: Apr1974, Vol. 2 Issue 2, p37; Subject Term: DENTAL care; Subject Term: WORLD health; Subject Term: HEALTH surveys; Subject Term: NORWAY; Subject Term: AUSTRALIA; Author-Supplied Keyword: dental health survey; Author-Supplied Keyword: dental manpower; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: oral; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1600-0528.ep17139089
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robertstad, Gordon W.
AU - Bennett, Betty
AU - Ajello, Libefo
T1 - Isolation of Microsporum Distortum from a Dog in the Southwestern United States.
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
Y1 - 1974/06//
VL - 1
IS - 3
M3 - Article
SP - 117
EP - 119
SN - 03036987
AB - Microsporum distortum from a mixed-breed dog residing in Tularosa, New Mexico, was isolated. Efforts to establish an association between this infected dog and New World monkeys, and to demonstrate that the organism is indigenous in the animal population of the Southwest U.S.A. were unsuccessful. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cutaneous Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROSPORUM
KW - DOGS
KW - MONKEYS
KW - ANIMALS -- Population biology
KW - DOG breeds
KW - SOUTHWESTERN States
N1 - Accession Number: 11793559; Robertstad, Gordon W. 1 Bennett, Betty 1 Ajello, Libefo 2; Affiliation: 1: Department of Biological Sciences, University of Texas a EL Paso. El Paso. Texas. 2: Centre for Disease Control. Health Services and Mental Health Administration. Public Health Service. U.S. Department of Health. Education and Welfare. Atlanta, Georgia, U.S.A.; Source Info: 1974, Vol. 1 Issue 3, p117; Subject Term: MICROSPORUM; Subject Term: DOGS; Subject Term: MONKEYS; Subject Term: ANIMALS -- Population biology; Subject Term: DOG breeds; Subject Term: SOUTHWESTERN States; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Markenson, J. A.
AU - Daniels, C. A.
AU - Notikins, A. L.
AU - Hoofnagle, J. H.
AU - Gerety, J.
AU - Barker, L. F.
T1 - THE INTERACTION OF RHEUMATOID FACTOR WITH HEPATITIS B SURFACE ANTIGEN-ANTIBODY COMPLEXES.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/02//
VL - 19
IS - 2
M3 - Article
SP - 209
EP - 217
PB - Wiley-Blackwell
SN - 00099104
AB - A solid phase radioimmunoassay was developed in which the hepatitis B surface antigen was adsorbed to the surface of plastic beads. When the antigen-coated beads were incubated with human !gG antibody against hepatitis B surface antigen, immune complexes were formed on the solid phase surface. 1gM rheumatoid factor was found to hind to the hepatitis B surface antigen-antibody complexes but not to the antigen or the lgG antibody alone. Since both hepatitis B surface antigen-antibody complexes and rheumatoid factor are commonly present in type B viral hepatitis, it is suggested that rheumatoid factor may play a rote in the pathogenesis of this viral disease in man. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOIMMUNOASSAY
KW - HEPATITIS B
KW - IMMUNE complexes
KW - IMMUNOGLOBULIN G
KW - RHEUMATOID arthritis
KW - VIRAL hepatitis
N1 - Accession Number: 15945465; Markenson, J. A. 1 Daniels, C. A. 2 Notikins, A. L. 3 Hoofnagle, J. H. 4 Gerety, J. 4 Barker, L. F. 4; Affiliation: 1: Department of Medicine, Cornell University Medical College, New York, New York 10021, U.S.A. 2: Department of Pathology, Duke University Medical Center, Durham, North Carolina. 3: Laboratory of Oral medicine, National Institute of Health, Bethesda, Maryland. 4: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Feb1975, Vol. 19 Issue 2, p209; Subject Term: RADIOIMMUNOASSAY; Subject Term: HEPATITIS B; Subject Term: IMMUNE complexes; Subject Term: IMMUNOGLOBULIN G; Subject Term: RHEUMATOID arthritis; Subject Term: VIRAL hepatitis; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyer, T.J.
AU - Azuma, I.
AU - Ribi, A.
T1 - Biologically Active Components from Mycobacterial Cell Walls.
JO - Immunology
JF - Immunology
Y1 - 1975/02//
VL - 28
IS - 2
M3 - Article
SP - 219
EP - 229
PB - Wiley-Blackwell
SN - 00192805
AB - The efficacy of various fractions of mycobacterial cell walls in producing experimental allergic encephalomyelitis (EAE) has been evaluated. BCG (Bacillus- Calmette-Guérin) cell walls were effective in producing EAE in all animals at dose levels as low as 40 μg. Study of subfractions of these cell walls revealed the following: (1) wax D was active, but required larger doses than BCG cell walls; (2) the chloroform-methanol-soluble (CMS) portion of wax D and P3 (a mycolic acid-trehalose ester contained therein) were inactive; (3) the chloroform-methanol- insoluble (CMI) portion of wax D was active; (4) exhaustively delipidated cell wall skeletons of BCG, Nocardia asteroides, Mycobacterium smegmatis, Corynebacterium diphtheriae and M. konsasii were active; (5) two water-soluble adjuvants prepared from mycobacteria were active. These results suggest that the mycobacterial structure responsible for EAE adjuvanticity is present in the organic solvent-insoluble cell wall skeleton framework. The activity of wax D may be due to the presence of cell-wall skeleton constituents which are found in varying quantity in most wax D preparations. Wax D components soluble in a solution of chloroforrn:methanol (diluted 2:1 v/v) do not produce EAE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGIC encephalomyelitis
KW - MYCOBACTERIA
KW - BACTERIAL cell walls
KW - BCG vaccination
KW - AUTOIMMUNE diseases
KW - GUINEA pigs
KW - IMMUNIZATION
N1 - Accession Number: 13370882; Meyer, T.J. 1 Azuma, I. 1 Ribi, A. 1; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National lnstitutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Feb75, Vol. 28 Issue 2, p219; Subject Term: ALLERGIC encephalomyelitis; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL cell walls; Subject Term: BCG vaccination; Subject Term: AUTOIMMUNE diseases; Subject Term: GUINEA pigs; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, Choong W.
AU - Carson, Theophilus R.
T1 - SENSITIZATION POTENTIALS AND IMMUNOLOGIC SPECIFICITIES OF NEOMYCINS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/03//
VL - 64
IS - 3
M3 - Article
SP - 158
EP - 164
SN - 0022202X
AB - The use of sensitization indices for expressing allergenic skin reactions in guinea pigs is described. The method is convenient for comparing allergens and cross-reacting substances and permits the use of both irritating and nonirritating challenge concentrations of allergens. It also permits determination of both optimal reading time and challenge concentrations for each experiment. By this technique commercial neomycin complex, neamine (neomycin A), neomycin B, neomycin C, and streptomycin were found to be allergenic in guinea pigs via intradermal (Id) and foot-pad (fp) immunizations. The immunizing emulsion consisted of an allergen and an adjuvant containing Mycobacterium butyricum (MB) or Mycobacterium tuberculosis H37Ra (Ra). The adjuvant MB was as effective as Ra by the id route, hut inferior to Ra by the fp route. The cross-reactivity of neomycin C was generally greater than neomycin B in guinea pigs sensitized to neamin, neomycin B, neomycin C, or streptomycin. In guinea pigs sensitized to neomycin complex by repeated immunizations, neomycins A. B, and C were effective elicitors of skin reactions, whereas the N -acetylated derivatives of the components failed to cause reactions. This finding is interpreted to mean that the amino groups of the amino-glycosides are the coupling sites to host proteins in the processes of sensitization and elicitation of skin reactions in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUINEA pigs as laboratory animals
KW - NEOMYCIN
KW - ANTIBACTERIAL agents
KW - ANTIBIOTICS
KW - ALLERGENS
KW - STREPTOMYCIN
N1 - Accession Number: 12533314; Chung, Choong W. 1 Carson, Theophilus R. 1; Affiliation: 1: Division of Toxicology, Food and Drug Administration, U. S. Department of Health, Education, and Welfare, Washington, D. C.; Source Info: Mar1975, Vol. 64 Issue 3, p158; Subject Term: GUINEA pigs as laboratory animals; Subject Term: NEOMYCIN; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTIBIOTICS; Subject Term: ALLERGENS; Subject Term: STREPTOMYCIN; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12533314
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Copeland, Edmund S.
AU - Grenan, Marie M.
AU - Yang, George C.
T1 - AN IN VITRO AND IN VIVO INVESTIGATION OF THE PHOTOTOXIC EFFECT AND ITS AMELIORATION WITH RADIOPROTECTIVE COMPOUNDS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1975/05//
VL - 64
IS - 5
M3 - Article
SP - 349
EP - 356
SN - 0022202X
AB - Electron spin resonance spectroscopy has been used to demonstrate that the phototoxic antimalarial drug, 6,8-dichloro-2-phenyl-α-2-piperidinylquinolinemethanol (WR 7930), when irradiated with long-wave ultraviolet (UV) light (A > 320 nm) while held in a glassy matrix at 73°K, enters a triplet state and releases hydrogen atoms in its environment. The steady-state concentration of triplet WR 7930 molecules and of hydrogen atoms is reduced 2 to 3 times when mercaptoethylamine (MEA) is also present in the UV-irradiated glass. Organosulfur radicals form on MEA while hydrogen atoms and triplet-state molecules are reduced in number. Hydrogen atoms and triplet WR 7930 molecules are considered as mediators of the phototoxicity of the antimalarial drug. Thus, hydrogen atom scavanging and chemical quenching of the triplet state are possible mechanisms by which protection against phototoxic effects could be gained. Protection is demonstrated in mice receiving 20 mg per kg WR 7930 intraperitoneally and exposed to long-wave UV for 20 hr when the radioprotective aminothiol-forming compound, 2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate (WR 2721), is administered at 400 mg per kg immediately before irradiation. When no protective drug is administered concurrently, WR 7930 administration results in intense erythema, edema, and eventual necrosis of ear tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION-protective agents
KW - SPECTRUM analysis
KW - THEORY of wave motion
KW - RESONANCE
KW - ATOMS
KW - HYDROGEN
N1 - Accession Number: 12512287; Copeland, Edmund S. 1 Grenan, Marie M. Yang, George C. 2; Affiliation: 1: Division of Biochemistry, Walter Reed Army Institute of Research, Washington, D. C. 2: Division of Chemistry and Physics, Food and Drug Administration, Washington, D. C.; Source Info: May75, Vol. 64 Issue 5, p349; Subject Term: RADIATION-protective agents; Subject Term: SPECTRUM analysis; Subject Term: THEORY of wave motion; Subject Term: RESONANCE; Subject Term: ATOMS; Subject Term: HYDROGEN; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12512287
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daugharty, H.
AU - Gogel, R.
T1 - RESPONSE IN GUINEA-PIGS TO INOCULATION WITH MIXTURES OF HEPATITIS B ANTIGEN AND ANTIBODY AT VARIABLE RATIOS.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1975/06//
VL - 20
IS - 3
M3 - Article
SP - 537
EP - 548
PB - Wiley-Blackwell
SN - 00099104
AB - Equivalence proportions of hepatitis B (HB) antigen (Ag) and antibody (Ab) positive plasmas were determined by liquid-phase radioimmunoassay (RIA). Variable proportions of HB Ab preincubated with HB Ag resulted in HB Ag:Ab ratios ranging from greater than to less than unity. Pairs of guinea-pigs were immunized intramuscularly with these mixtures and bled at approximately 3-week intervals. Sera were tested by RIA for presence of HB Ag and Ab. Animal, injected with a four-fold equivalence excess of HB Ab did not respond with Ab to HB Ag. Only at an equivalence ratio (1:1) for HB:Ag did one of two animals demonstrate a stable and consistent immune response. This began it the 11th week after inoculation. The earliest immune response detected in both guinea-pigs of a pair was when HB Ag was given at a four-fold equivalence excess over the Ab. This response was noted as early as 5 weeks. Quantitatively, the immune responses correlated very well with the HB Ag dose, i.e. higher Ag: Ab ratios resulted in greater anti-HB responses. Very low levels of antigenaemia were evidenced by test specimens inhibiting the precipitation of 125-labelled HB in RIA and these levels persisted for 4½ months. Ant igenaemia was noted only for those animals which received mixtures of lower ratios of Ag : Ab as inoculum. Excess Ab caused immunological suppression rather than the enhancement that might be expected to occur with Ag : Ah complexes alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B
KW - IMMUNE response
KW - IMMUNOLOGY
KW - RADIOIMMUNOASSAY
KW - BLOOD plasma
KW - LIVER diseases
N1 - Accession Number: 15951193; Daugharty, H. 1 Gogel, R. 1; Affiliation: 1: Viral Immunology Branch, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, Georgia, U.S.A.; Source Info: Jun1975, Vol. 20 Issue 3, p537; Subject Term: HEPATITIS B; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: RADIOIMMUNOASSAY; Subject Term: BLOOD plasma; Subject Term: LIVER diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilms, Heinz G.
AU - Moss, C. Eugene
T1 - A Bookshelf on Radiological Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1975/11//
VL - 65
IS - 11
M3 - Article
SP - 1231
EP - 1237
PB - American Public Health Association
SN - 00900036
AB - The article presents a bookshelf on radiological health, which attempts to list, categorize, and present details on the many varied sources of information available to personnel's working in the field. It concentrates on those sources published or revised after 1965. It also attempts to restrict the number of sources to those more associated with public health aspects. The bookshelf is fractioned into four main sections, including textbooks, current literature, training and educational materials, and other sources. Each one of these sections is further stratified into additional details.
KW - LIBRARY materials
KW - INFORMATION resources
KW - ARCHIVAL materials
KW - PUBLISHERS & publishing
KW - HANDBOOKS, vade-mecums, etc.
KW - TEXTBOOKS
KW - MEDICAL radiology
KW - RADIOLOGY
KW - PUBLIC health
N1 - Accession Number: 5659934; Wilms, Heinz G. 1 Moss, C. Eugene 1; Affiliation: 1: Food and Drug Administration, U.S. Department of Health, Education, and Welfare, Rockville, Maryland 20852; Source Info: Nov75, Vol. 65 Issue 11, p1231; Subject Term: LIBRARY materials; Subject Term: INFORMATION resources; Subject Term: ARCHIVAL materials; Subject Term: PUBLISHERS & publishing; Subject Term: HANDBOOKS, vade-mecums, etc.; Subject Term: TEXTBOOKS; Subject Term: MEDICAL radiology; Subject Term: RADIOLOGY; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 511190 Other publishers; NAICS/Industry Codes: 511130 Book Publishers; NAICS/Industry Codes: 511199 All Other Publishers; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 323119 Other printing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lechnyr, Ronald J.
T1 - Learn from the Teachers.
JO - Social Work
JF - Social Work
Y1 - 1976/01//
VL - 21
IS - 1
M3 - Article
SP - 75
PB - Oxford University Press / USA
SN - 00378046
AB - The article presents a commentary on the changes in education recommended by the Council of Social Work Education and how they will affect the social work profession. It provides reason for the willingness of administrators of agencies to keep salaries low and growth of master's degree programs in social work. It also focuses on the development of a social work practice and the conversion of master's degrees into doctoral degrees on a retroactive basis. The rapid growth of master's degree programs in social work is outstripped only by the rapid growth of BSW programs. Though this will encourage the hiring of BSWs, even in public welfare agencies, it is also probable that these BSWs will be hired at various levels, since employers are essentially not familiar with the variety of training programs and specializations within the field of social work. As a result the more highly trained people will be forced into other areas of practice or unemployment. It is doubtful that most employers would be willing to pay the salary demanded by doctoral degree holders who want to enter the practice field.
KW - SOCIAL services
KW - SOCIAL work education
KW - INCOME
KW - WAGES
KW - OCCUPATIONAL training
KW - HUMAN services
KW - PUBLIC welfare
N1 - Accession Number: 5267637; Lechnyr, Ronald J. 1; Affiliation: 1: Chief, Mental Health Service, U. S. Public Health Service, Gallup Indian Medical Center, Gallup, N. M..; Source Info: Jan76, Vol. 21 Issue 1, p75; Subject Term: SOCIAL services; Subject Term: SOCIAL work education; Subject Term: INCOME; Subject Term: WAGES; Subject Term: OCCUPATIONAL training; Subject Term: HUMAN services; Subject Term: PUBLIC welfare; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bakers, Lawrence D.
AU - Yert, Louise W.
AU - Chase, Mary C.
AU - Dale, Edwin
T1 - Evaluation of a 'Do-It-Yourself' Pregnancy Test.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/02//
VL - 66
IS - 2
M3 - Article
SP - 166
PB - American Public Health Association
SN - 00900036
AB - The article presents information on the evaluation of the Ova II Preliminary Screening Test for pregnancy. It was evaluated by comparing the result with standard laboratory tests for urinary chorionic gonadotrophin. The test is performed to determine both its theoretical and use effectiveness. Theoretical effectiveness was defined as the accuracy of the test when performed by professional laboratory personnel according to the manufacturer's instructions. In contrast , use effectiveness was as the accuracy of the product when performed by the untrained consumer. Participants were admitted to Grady Memorial Hospital for a suction curettage outpatient abortion, and employees of the U.S. Center for Disease Control who at the time of the pregnancy test believed themselves not pregnant.
KW - PREGNANCY
KW - DIAGNOSIS
KW - GONADOTROPIN
KW - WOMEN -- Health
KW - BIRTH control
KW - WOMEN employees
KW - PUBLIC health
KW - VACUUM curettage
KW - UNITED States
N1 - Accession Number: 5666029; Bakers, Lawrence D. 1,2 Yert, Louise W. 1,2 Chase, Mary C. 1,2 Dale, Edwin 1,2; Affiliation: 1: Department of Health, Education and Welfare, Public Health Service, Center for Disease Control, Bureau of Epidemiology 2: Department of Gynecology and Obstetries Emory University School of Medicine, Atlanta, GA.; Source Info: Feb1976, Vol. 66 Issue 2, p166; Subject Term: PREGNANCY; Subject Term: DIAGNOSIS; Subject Term: GONADOTROPIN; Subject Term: WOMEN -- Health; Subject Term: BIRTH control; Subject Term: WOMEN employees; Subject Term: PUBLIC health; Subject Term: VACUUM curettage; Subject Term: UNITED States; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marzulli, Francis N.
AU - Maibach, Howard I.
T1 - Contact allergy: Predictive testing in man.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1976/02//
VL - 2
IS - 1
M3 - Article
SP - 1
EP - 17
SN - 01051873
AB - Predictive tests are of value in forecasting the response of a population to a sensitizer; diagnostic testing is used to determine what substances may actually be producing dermatologic problems. Skin sensitization predictive and diagnostic data for the eleven most frequently encountered skin sensitizers in Western Europe, Canada and the United States are reviewed. These compounds include two drugs (benzocaine and neomycin), two cosmetic ingredients (p-phenylenediamine and balsam of Peru), four preservatives (formaldehyde, ethylenediamine, parabens and mercurials) and three ingredients of wearing apparel (nickel, chromium and thiram). Many of the data were collected by the North American Contact Dermatitis Group and the International Contact Dermatitis Research Group on tests with 1,200 and 4,825 dermatologic patients, respectively; the remainder were obtained by individual investigators with smaller groups of subjects. The data obtained by various investigators are discussed in relation to the factors which affect the extent and degree of sensitization which they can cause. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - DERMATOLOGY
KW - ALLERGY
KW - SKIN
KW - CUTANEOUS manifestations of general diseases
KW - SKIN tests
KW - allergens
KW - dermatology
KW - hypersensitivity
KW - patch tests
KW - predictive testing
KW - skin
KW - skin manifestations
KW - skin tests.
N1 - Accession Number: 12191392; Marzulli, Francis N. 1 Maibach, Howard I. 2; Affiliation: 1: Division of Toxicology, Food and Drug Administration, Washington, U.S.A. 2: Department of Dermatology, University of California Medical Center, San Francisco, California, U.S.A.; Source Info: 1976, Vol. 2 Issue 1, p1; Subject Term: ALLERGENS; Subject Term: DERMATOLOGY; Subject Term: ALLERGY; Subject Term: SKIN; Subject Term: CUTANEOUS manifestations of general diseases; Subject Term: SKIN tests; Author-Supplied Keyword: allergens; Author-Supplied Keyword: dermatology; Author-Supplied Keyword: hypersensitivity; Author-Supplied Keyword: patch tests; Author-Supplied Keyword: predictive testing; Author-Supplied Keyword: skin; Author-Supplied Keyword: skin manifestations; Author-Supplied Keyword: skin tests.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 17p; Document Type: Article
L3 - 10.1111/1600-0536.ep12191392
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Abdellah, Faye G.
T1 - Nurse Practitioners and Nursing Practice.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/03//
VL - 66
IS - 3
M3 - Editorial
SP - 245
PB - American Public Health Association
SN - 00900036
AB - The article reflects on the expanded role of nurse practitioners in the health care delivery system in the U.S. The author contends that the role of professional nurses is expanding to include broader functions in the realm of nursing practice which sometimes overlap the responsibilities of the physicians. She comments on the doubtless innovative changes in the systems of nursing education and stresses the significance of nurses in achieving improved health care for all Americans.
KW - NURSING service administration
KW - NURSING -- Law & legislation
KW - NURSE practitioners
KW - NURSES -- United States
KW - MEDICAL care -- United States
KW - UNITED States
N1 - Accession Number: 5672457; Abdellah, Faye G. 1,2,3; Affiliation: 1: Assistant Surgeon General, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852. 2: Chief Nurse Officer, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852. 3: Director, Office of Nursing Home Affairs, U. S. Public Health Service, Department of Health, Education, and Welfare, Rockville, MD 20852.; Source Info: Mar1976, Vol. 66 Issue 3, p245; Subject Term: NURSING service administration; Subject Term: NURSING -- Law & legislation; Subject Term: NURSE practitioners; Subject Term: NURSES -- United States; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chopra, Joginder G.
T1 - Current Regulatory Status of Foods For Special Dietary Uses.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/04//
VL - 66
IS - 4
M3 - Article
SP - 351
PB - American Public Health Association
SN - 00900036
AB - The Food and Drug Administration has redefined foods for "special dietary use". Such foods must now: (1) Supply a special dietary need that exists by reason of a physical or physiological condition, such as convalescence, a pregnancy, lactation, or by reason of a specific disease or disorder; (2) Supply a vitamin, mineral, or other dietary property to supplement diet by increasing total dietary intake; (3) Meet a special nutritional need as the sole item of the diet. The stricter definition of this category of food means that the conventional foods with added nutrients or food for which nutritional claims are made or nutritional information provided will no longer be considered as foods for special dietary uses, although they must conform to standard nutritional labeling requirements. The new regulation establishes a clearly delineated position within which the consumer, industry, and FDA can deal with special dietary foods without the past confusion as to what belonged in this category. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD law & legislation
KW - FOOD labeling
KW - DIETARY supplements
KW - FOOD additives
KW - PANTOTHENIC acid
KW - BREASTFEEDING (Humans)
KW - DIET therapy
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 5666149; Chopra, Joginder G. 1; Affiliation: 1: Special Assistant for Medical Affairs, Office of Nutrition and Consumer Sciences, Bureau of Foods, Food and Drug Administration.; Source Info: Apr1976, Vol. 66 Issue 4, p351; Subject Term: FOOD law & legislation; Subject Term: FOOD labeling; Subject Term: DIETARY supplements; Subject Term: FOOD additives; Subject Term: PANTOTHENIC acid; Subject Term: BREASTFEEDING (Humans); Subject Term: DIET therapy; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levine, Richard J.
AU - Moore Jr., Roscoe M.
AU - McLaren, Gordon D.
AU - Barthel, William F.
AU - Landrigan, Philip J.
T1 - Occupational Lead Poisoning, Animal Deaths, and Environmental Contamination at a Scrap Smelter.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1976/06//
VL - 66
IS - 6
M3 - Article
SP - 548
PB - American Public Health Association
SN - 00900036
AB - Occupational lead poisoning and environmental contamination were evaluated at a lead scrap smelter. Thirty of 37 employees (81 percent) had blood lead levels of ≥ 8O μg/100ml, indicating unacceptable absorption, and 35 had free erythrocyte protoporphyrin (FEP) levels >60 μg/100ml rbc, indicating toxicity of lead on heme metabolism in red blood cells; eight current and previous employees had been hospitalized with lead colic, and another with encephalopathy. Levels of lead in surface soil(1,800 ppm) and vegetation (20,000 ppm) at the smelter were high and decreased with distance. Animals on nearby pasture had died, and lead levels in the blood, milk, and hair of large and small animals were elevated. Adults living within 100 meters of the smelter had higher blood and hair lead levels than controls, who lived at greater distances, but there was no evidence in them of lead toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAD poisoning
KW - EMPLOYEES
KW - POLLUTANTS
KW - ERYTHROCYTES
KW - LEAD -- Toxicology
KW - HEPATIC encephalopathy
KW - PUBLIC health
KW - AUTOMOBILE batteries
KW - UNITED States
N1 - Accession Number: 5666080; Levine, Richard J. 1 Moore Jr., Roscoe M. 1 McLaren, Gordon D. 1 Barthel, William F. 1 Landrigan, Philip J. 1; Affiliation: 1: Bureau of Epidemiology and Bureau of Laboratories, U.S. Dept. of Health, Education, and Welfare, Public Health Service, Center for Disease Control, Atlanta, GA.; Source Info: Jun76, Vol. 66 Issue 6, p548; Subject Term: LEAD poisoning; Subject Term: EMPLOYEES; Subject Term: POLLUTANTS; Subject Term: ERYTHROCYTES; Subject Term: LEAD -- Toxicology; Subject Term: HEPATIC encephalopathy; Subject Term: PUBLIC health; Subject Term: AUTOMOBILE batteries; Subject Term: UNITED States; NAICS/Industry Codes: 441310 Automotive Parts and Accessories Stores; NAICS/Industry Codes: 415290 Other new motor vehicle parts and accessories merchant wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coe, J.E.
AU - Leong, D.
AU - Portis, J.L.
AU - Thomas, L.A.
T1 - Immune response in the garter snake (Thamnophis ordinoidesJournal of Nursing Administration (1976) March-April. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Advanced Nursing is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - NURSING research
KW - ACTION research in nursing
KW - CARE of the sick
KW - FORUMS (Discussion & debate)
KW - LOUISIANA
KW - UNITED States
N1 - Accession Number: 14276639; Gortner, Susan R. 1 Bloch, Doris 1 Phillips, Thomas P. 1; Affiliation: 1: Nursing Research Branch, Division of Nursing, Bureau of Health Manpower, Health Resources Administration, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.; Source Info: Nov76, Vol. 1 Issue 6, p507; Subject Term: MEDICAL care; Subject Term: NURSING research; Subject Term: ACTION research in nursing; Subject Term: CARE of the sick; Subject Term: FORUMS (Discussion & debate); Subject Term: LOUISIANA; Subject Term: UNITED States; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/1365-2648.ep14276639
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marzulli, Francis N.
AU - Maibach, Howard J.
T1 - Effects of vehicles and elicitation concentration in contact dermatitis testing I. Experimental contact sensitization in humans.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1976/12//
VL - 2
IS - 6
M3 - Article
SP - 325
EP - 329
SN - 01051873
AB - A study was made to evaluate the effects of vehicle and challenge concentration on response of human subjects to potential allergens. In the vehicle studies the modified Draize Lest was used to test the response of subjects to cinnamic aldehyde and to costus oil, administered at two skin sites, in petrolatum and in 95 % ethyl alcohol. In two tests of costus oil, alcohol proved to be more effective in eliciting a response than petrolatum; on the other hand, in one test with cinnamic aldehyde. no difference in result was obtained with these two vehicles. In the concentration studies, subjects known to be sensitive to the test substance were tested by the A1® test with costus nit (three concentrations), chloracetamide (four concentrations), or thimerosal (three concentrations): petrolatum was used as the vehicle in each case. Results of the vehicle test showed no compelling reason for the selection of one vehicle rather than another. Results of the concentration tests indicated that concentration does have an effect on the intensity and frequency of reactions to potential allergens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIAL sensitivity tests
KW - SKIN -- Inflammation
KW - ALLERGENS
KW - ALDEHYDES
KW - ALCOHOL
KW - SKIN tests
KW - Cosmetic ingredients
KW - elicitation concentration
KW - human experimental work
KW - vehicle effect.
N1 - Accession Number: 12156510; Marzulli, Francis N. 1 Maibach, Howard J. 2; Affiliation: 1: Division of Toxicology, Food and Drug Administration, Washington, D.C. 2: Department of Dermatology, University of California, Medical Center, San Francisco, California, U.S.A.; Source Info: 1976, Vol. 2 Issue 6, p325; Subject Term: MICROBIAL sensitivity tests; Subject Term: SKIN -- Inflammation; Subject Term: ALLERGENS; Subject Term: ALDEHYDES; Subject Term: ALCOHOL; Subject Term: SKIN tests; Author-Supplied Keyword: Cosmetic ingredients; Author-Supplied Keyword: elicitation concentration; Author-Supplied Keyword: human experimental work; Author-Supplied Keyword: vehicle effect.; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1600-0536.ep12156510
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hsu, C. C. S.
AU - Marti, G. E.
AU - Mittal, K. K.
T1 - Antisera against leukaemia-associated antigens on human lymphocytes.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/03//
VL - 27
IS - 3
M3 - Article
SP - 487
EP - 496
PB - Wiley-Blackwell
SN - 00099104
AB - Antisera were raised in rabbits against leukaemic lymphosarcoma (LSL) cells which carried surface markers of both thymus-derived T lymphocytes (T cells) and bone marrow-derived B lymphocytes (B cells). After absorption with leucocytes, erythrocytes and serum proteins from normal individuals, the antisera demonstrated significant complement-dependent cytotoxicity against leukaemic cells from patients with acute lymphoblastic leukaemia (ALL) (9/11), LSL (7/9) and chronic lymphocytic leukaemia (CLL) (9/12), with an antibody titre of 1:64 or greater. The antisera did not react with: (a) blood lymphocytes from clinically healthy individuals (0/23), patients with non-lymphoproliferative disorders (0/8) and normal umbilical cords (0/3), (h) normal lymphocytes stimulated by pokeweed mitogen (0/7), allogeneic lymphocytes (0/3), fetuin (0/1), purified protein derivative (PPD) (0/2), and candida antigen (0/1); (c) normal marrow cells (0/3), (d) normal thymocytes (0/2) and (e) leukaemic cells from patients with acute mycloblastic (AML) (0/10) and chronic granulocytic leukaemia (CGL) (0/3), However, the antisera did react with lymphoblastoid cells from continuous B-cell lines derived from an AML patient and from a non-leukaemic individual and, to a lesser extent, with lymphocytes from patients with infectious mononucleosis. The antisera also reacted with lymphocytes from chronically infected tonsils. Cytotoxicity of the antisera against lymphoblastoid and tonsillar cells was inhibited by ALL and CLL cell-lysates; and, conversely, cytotoxicity against ALL cells was inhibited by the lymphoblastoid cell extract. In contrast, a cell lysate or extract from normal lymphocytes did not inhibit cytotoxicity toward lymphoblastoid, tonsillar or ALL cells. Cytotoxicity of the antisera was neutralized by a goat anti-rabbit IgG (GAR IgG). These results suggest that the antisera contained antibodies reactive with antigens possibly common to neoplastic lymphocytes, tonsillar cells, lymphoblastoid cells and some blood lymphocytes from patients with infectious mononucleosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE serums
KW - ANTIGENS
KW - LYMPHOCYTES
KW - RABBITS
KW - HODGKIN'S disease
KW - PROTEINS
N1 - Accession Number: 15945769; Hsu, C. C. S. 1,2 Marti, G. E. 1,2 Mittal, K. K. 1,2; Affiliation: 1: Samuel J. Sackett Research Laboratories, Infectious Disease-Hypersensitivity Section, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois. 2: Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Mar1977, Vol. 27 Issue 3, p487; Subject Term: IMMUNE serums; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: RABBITS; Subject Term: HODGKIN'S disease; Subject Term: PROTEINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112930 Fur-Bearing Animal and Rabbit Production; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fésüs, L.
AU - Csaba, B.
AU - Muszbek, L.
T1 - Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1977/03//
VL - 27
IS - 3
M3 - Article
SP - 512
EP - 515
PB - Wiley-Blackwell
SN - 00099104
AB - Platelet-activating factor (PAF) generated by an IgE-mediated reaction in the peritoneal cavity of rats was partially purified by adsorption to diatomaceous earth. It aggregated rat platelets and, as a consequence, activated Hageman factor in in vitro, as well as in in vivo, conditions. The haemostatic alterations induced by PAF showed similarity to those observed in the early phase of rat anaphylaxis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelets
KW - RATS
KW - ADSORPTION
KW - ANAPHYLAXIS
KW - DIATOMACEOUS earth
KW - PLATELET activating factor
N1 - Accession Number: 15946303; Fésüs, L. 1 Csaba, B. 1 Muszbek, L. 2,3; Affiliation: 1: National Institute of Arthritis, Metabolism and Digestive Diseases 2: National Institute of Health, Public Health Service U.S. 3: Department of Health, Education and Welfare, Bethesda, Maryland, U.S.A.; Source Info: Mar1977, Vol. 27 Issue 3, p512; Subject Term: BLOOD platelets; Subject Term: RATS; Subject Term: ADSORPTION; Subject Term: ANAPHYLAXIS; Subject Term: DIATOMACEOUS earth; Subject Term: PLATELET activating factor; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gershwin, M.E.
AU - Merchant, B.
AU - Steinberg, A.D.
T1 - The effects of synthetic polymeric agents on immune responses of nude mice.
JO - Immunology
JF - Immunology
Y1 - 1977/03//
VL - 32
IS - 3
M3 - Article
SP - 327
PB - Wiley-Blackwell
SN - 00192805
AB - Investigates the influence of synthetic polymeric agents on the immune responsiveness of congenitally athymic nude mice by determining the effects of in vivo treatment with polynucleotides and polymeric haptenated antigens on splenic theta-bearing cells. Cell responses to thymic dependent and thymic independent antigens; Absence of acquisition of improved T-cell function in nude mice.
KW - IMMUNE response
KW - NUDE mouse
KW - POLYMERS
KW - NUCLEIC acids
N1 - Accession Number: 11161102; Gershwin, M.E. 1,2 Merchant, B. 1,2 Steinberg, A.D. 1,2; Affiliation: 1: Department of Medicine, University of California at Davis 2: Immunology Branch, Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration and the Arthritis and Rheumatism Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Maryland; Source Info: Mar77, Vol. 32 Issue 3, p327; Subject Term: IMMUNE response; Subject Term: NUDE mouse; Subject Term: POLYMERS; Subject Term: NUCLEIC acids; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perez, Maryln K.
T1 - Food and drug administration statement of problem.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 727
EP - 730
SN - 00984108
N1 - Accession Number: 75456792; Perez, Maryln K. 1; Affiliation: 1: Bureau of Foods, Food and Drug Administration, Washington, D.C.; Source Info: Mar1977, Vol. 2 Issue 4, p727; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/15287397709529475
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mercer, H. D.
AU - Baggot, J. D.
AU - Sams, R. A.
T1 - Application of pharmacokinetic methods to the drug residue profile.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/03//
VL - 2
IS - 4
M3 - Article
SP - 787
EP - 801
SN - 00984108
AB - A pharmacokinetic approach to the delineation of a drug residue profile in food‐producing animals has been presented. It is recognized that the determination of a drug withdrawal period is one of the costly developmental procedures in drug development for food animals; thus it is believed that in the early developmental phases, a thorough pharmacokinetic characterization of a drug in the target species would greatly facilitate the design and quality of studies conducted in the later phases of new drug development. It is suggested that drugs that are intended for use in food animals can be characterized kinetically in less costly studies, the results of which might be used to determine the feasibility of developing a drug that might cause serious residue problems. It is also suggested that the pharmacokinetic modeling of a drug in the target animal may provide an essential data base for calculating dosage rates and intervals that directly relate to the efficacy aspects of drug development. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456796; Mercer, H. D. 1 Baggot, J. D. 2 Sams, R. A. 3; Affiliation: 1: Division of Veterinary Medical Research, Bureau of Veterinary Medicine, Food and Drug Administration, Beltsville, Maryland, 20705 2: School of Veterinary Studies, Murdock University, Murdock, West Australia 3: College of Veterinary Medicine, Department of Veterinary Physiology and Pharmacology, Ohio State University, Columbus, Ohio; Source Info: Mar1977, Vol. 2 Issue 4, p787; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/15287397709529479
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greif, Martin
AU - Howard I. Maibach
T1 - United States cosmetic ingredient labeling.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1977/04//
VL - 3
IS - 2
M3 - Article
SP - 94
EP - 97
SN - 01051873
AB - United states federal regulations require ingredient listing on cosmetics labeled after November 30, 1976. Standardized ingredient nomenclature from a reference text will be utilized to minimize confusion which might arise if various synonyms for chemical names were used. This new information on cosmetics labeling will assist physicians in the diagnosis of cosmetic-related dermatoses. It should facilitate the patch testing procedure by enabling the dermatologist to focus attention on suspect ingredients early in the evaluation. Once the identify of offending ingredients in a cosmetic has been determined for a particular patient, the individual will have the opportunity to avoid those ingredients and related ingredients in future purchases of cosmetics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COSMETICS
KW - SKIN diseases -- Diagnosis
KW - PERSONAL beauty
KW - DERMATOLOGISTS
KW - FEDERAL regulation
KW - LABELING
KW - UNITED States
KW - Cosmetic allergy
KW - cosmetic ingredients
KW - cosmetics
KW - cosmetics.
KW - dermatitis
KW - ingredients disclosure
N1 - Accession Number: 11929233; Greif, Martin 1 Howard I. Maibach 2; Affiliation: 1: Division of Cosmetics Technology, Food and Drug Administration, Washington, D.C., USA. 2: Department of Dermatology, University of California Medical Center, San Francisco, California, USA.; Source Info: 1977, Vol. 3 Issue 2, p94; Subject Term: COSMETICS; Subject Term: SKIN diseases -- Diagnosis; Subject Term: PERSONAL beauty; Subject Term: DERMATOLOGISTS; Subject Term: FEDERAL regulation; Subject Term: LABELING; Subject Term: UNITED States; Author-Supplied Keyword: Cosmetic allergy; Author-Supplied Keyword: cosmetic ingredients; Author-Supplied Keyword: cosmetics; Author-Supplied Keyword: cosmetics.; Author-Supplied Keyword: dermatitis; Author-Supplied Keyword: ingredients disclosure; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1600-0536.ep11929233
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, Choong W.
AU - Giles Jr., Albert L.
T1 - SENSITIZATION POTENTIALS OF METHYL, ETHYL, AND n -BUTYL METHACRYLATES AND MUTUAL CROSS-SENSITIVITY IN GUINEA PIGS.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/04//
VL - 68
IS - 4
M3 - Article
SP - 187
EP - 190
SN - 0022202X
AB - Guinea pigs could be strongly sensitized to methyl, ethyl, and n-butyl methacrylates in ethanol or olive oil by the topical route, or in saline by the intradermal route. For elicitation of skin reactions, topical challenge with the compounds in olive oil or intradermal challenge with saline as the solvent was necessary. Topical challenge with the methacrylates in ethanol failed to elicit any allergic skin reactions because of their volatility. All sensitized animals responded strongly not only to the inducing methacrylate but also to the other methacrylates, showing that mutual cross-sensitivity had occurred. Since methyl methacrylate has been reported to be a potent sensitizer in humans, the guinea-pig model described here may be useful for screening products before marketing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYL methacrylate
KW - SENSITIVITY (Personality trait)
KW - GUINEA pigs as laboratory animals
KW - ALCOHOL
KW - OLIVE oil
KW - SKIN
KW - ALLERGY
N1 - Accession Number: 12492663; Chung, Choong W. 1 Giles Jr., Albert L. 2; Affiliation: 1: Division of Toxicology, Food and Drug Administration, U. S.. 2: Department of Health, Education, and Welfare, Washington, D. C., U.S.A..; Source Info: Apr77, Vol. 68 Issue 4, p187; Subject Term: METHYL methacrylate; Subject Term: SENSITIVITY (Personality trait); Subject Term: GUINEA pigs as laboratory animals; Subject Term: ALCOHOL; Subject Term: OLIVE oil; Subject Term: SKIN; Subject Term: ALLERGY; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12492663
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levin, Marvin P.
AU - Grower, Marvin F.
AU - Cutright, Duane E.
AU - Getter, Lee
T1 - The effects of length of surgery on healing of full and partial thickness flaps.
JO - Journal of Oral Pathology
JF - Journal of Oral Pathology
Y1 - 1977/05//
VL - 6
IS - 3
M3 - Article
SP - 152
EP - 160
SN - 03009777
AB - Partial and full thickness flaps which were made in the facial gingiva of 10 dogs were reflected for 15 or 90 min. Specimens were examined histologically and biochemically from 3 to 28 days after initial surgery. The results indicate that flaps reflected for 15 min exhibited faster epithelial closure than those reflected for 90 min. Partial thickness flaps reflected for both 15 and 90 min showed less inflammation than full thickness flaps at 3 and 7 days post surgery and healed faster in respect to epithelial closure, mesenchymal healing, and. bone regeneration. Biochemical analysis of the collagen concentration of the tissue flaps revealed similar collagen content in full and partial thickness flaps reflected for 15 min; however, the collagen concentration of partial thickness flaps opened for 90 min was higher than that in full thickness flaps. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASTIC surgery
KW - SURGICAL flaps
KW - COLLAGEN
KW - GUMS
KW - EPITHELIAL cells
KW - BONE regeneration
N1 - Accession Number: 14869023; Levin, Marvin P. 1 Grower, Marvin F. 1 Cutright, Duane E. 1 Getter, Lee 2; Affiliation: 1: U. S. Army Institute of Dental Research, Walter Reed Army Medical Center, Washington. 2: Office of the Surgeon General, The Pentagon, Washington, D.C. 20310, U. S. A.; Source Info: 1977, Vol. 6 Issue 3, p152; Subject Term: PLASTIC surgery; Subject Term: SURGICAL flaps; Subject Term: COLLAGEN; Subject Term: GUMS; Subject Term: EPITHELIAL cells; Subject Term: BONE regeneration; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/1600-0714.ep14869023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Highman, B.
AU - Gaines, T. B.
AU - Schumacher, H. J.
T1 - Retarded development of fetal renal alkaline phosphatase in mice given 2,4,5‐trichlorophenoxyacetic acid.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1007
EP - 1018
SN - 00984108
AB - Histologic study of the fetal offspring of maternal mice given 2,4,5‐trichlorophenoxy‐acetic acid (2,4,5‐T) suggested that the previously reported fetal “cystic kidneys” were due to a retardation in fetal renal development and downgrowth of the renal papilla into the pelvis. To determine a possible retardation in renal alkaline phosphatase or functional development, maternal mice received by gavage 60–120 mg/kg, 2,4,5‐T on days 6–14 of pregnancy. At necropsy on day 17, the fetal kidneys were excised and fixed 24 hr in cold 65% ethanol. Paraffin sections stained by Gomori's method revealed alkaline phosphatase mainly in tubules in the inner renal cortex. Fetal kidneys showing diminished or no alkaline phosphatase were designated subnormal. There was a statistically significant greater incidence of subnormal fetal kidneys in the 2,4,5‐T‐treated mice than in the untreated controls. In three experiments, some mice were also sacrificed on day 18, and the incidence of subnormal fetal kidneys was significantly lower than on day 17. This retardation in renal alkaline phosphatase development indicates a retardation in renal functional development and indirectly supports the view that 2,4,5‐T also retards the morphological development of the fetal kidney and is not a renal teratogen in mice. It also illustrates that selected histochemical studies may be helpful in a teratologic investigation. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456843; Highman, B. 1,2 Gaines, T. B. 3 Schumacher, H. J. 3; Affiliation: 1: Department of Pathology, University of Arkansas, Medical Sciences, Little Rock 2: Division of Pathology Services, National Center for Toxicological Research, Jefferson, Arkansas, 72079 3: National Center for Toxicological Research, Jefferson, Arkansas; Source Info: May1977, Vol. 2 Issue 5, p1007; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287397709529499
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Freudenthal, Ralph I.
AU - Kerchner, Gail A.
AU - Persing, Ronald L.
AU - Baumel, Irwin
AU - Baron, Ronald L.
T1 - Subacute toxicity of ethylenebisisothiocyanate sulfide in the laboratory rat.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1067
EP - 1078
SN - 00984108
AB - Ethylenebisisothiocyanate sulfide (EBIS) was administered in the diet to groups of rats at 0, 1, 10, 100, and 1,000 ppm for up to 90 days. The rats receiving EBIS at 1,000 ppm demonstrated a toxic response within 8–14 days, reflected as a reversible paralysis of the hind legs. If left on the 1,000 ppm diet, the animals soon died. When removed from the diet, the animals recovered, only to become atoxic on further dietary exposure at the high level. No histologic lesion could be identified in either H&E‐ or luxol fast blue‐stained sections of brain, spinal cord, or peripheral nerves from the paralyzed animals. The ability to reverse the paralysis by removing the animals from the test diet coupled with the lack of histologically observable lesions suggests a biochemical (reversible) rather than somatic lesion. Ingestion of 1,000 ppm EBIS for 7 days resulted in measurable changes in thyroid function. Total serum thyroxine levels were markedly decreased, as was iodide uptake by the thyroid. Ingestion of EBIS at dietary levels of 100, 10, 1, and 0 ppm for 90 days produced no observable adverse effect. Growth, as seen by body weight increases, diet consumption, and thyroid function, was normal. No EBIS‐related lesions were detected during the histopathologic evaluation of major tissues and organs taken from rats fed 100 ppm EBIS or control diets. In this 90 day dietary study with EBIS, no effects were noted at a level of 100 ppm in the diet, equivalent to an average intake ranging from 67 mg/kg body weight at week 1 to 31 mg/kg body weight at week 12. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456848; Freudenthal, Ralph I. 1 Kerchner, Gail A. 2 Persing, Ronald L. 2 Baumel, Irwin 3,4 Baron, Ronald L. 5; Affiliation: 1: Battelle, Columbus Laboratories, 505 King Avenue, Columbus, Ohio, 43201 2: Battelle, Columbus Laboratories, Columbus, Ohio 3: U.S. Environmental Protection Agency, Washington, D.C. 4: National Institute for Occupational Safety and Health, Rockville, Maryland, 20852 5: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; Source Info: May1977, Vol. 2 Issue 5, p1067; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287397709529504
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haley, Thomas J.
T1 - Maleic hydrazide: Should the Delaney amendment apply to its use?
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1085
EP - 1094
SN - 00984108
AB - The chemistry, metabolism, toxicology, mutagenicity, and carcinogenicity of maleic hydrazide have been reviewed. There is little doubt that this chemical is a mutagen and a carcinogen in cell cultures and animals, but no evidence is available on human carcinogenicity regardless of population exposure in manufacturing, agriculture, and the food chain (i.e., potato chips). An epidemiology survey should be conducted to ascertain possible human carcinogenicity in these populations. A long‐term ingestion experiment should be conducted in several animal species to establish whether maleic hydrazide is carcinogenic by this route. Biotransformation studies should be undertaken along with pharmacokinetic studies to obtain a better understanding of the chemical's metabolism and excretion. Such investigations would firmly establish whether the tolerance for maleic hydrazide should remain or whether the use of the compound should be banned under the Delaney Amendment. [ABSTRACT FROM PUBLISHER]
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N1 - Accession Number: 75456850; Haley, Thomas J. 1; Affiliation: 1: Department of Health, Education and Welfare, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, 72079; Source Info: May1977, Vol. 2 Issue 5, p1085; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397709529506
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, James E.
AU - Cranmer, Morris F.
AU - Peoples, Anita J.
T1 - Effects of diphenylhydantoin and chloroquine on monkey liver microsomal mixed‐function oxidases.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1193
EP - 1199
SN - 00984108
AB - Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed‐function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed‐function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456861; Davis, James E. 1 Cranmer, Morris F. 2 Peoples, Anita J. 3; Affiliation: 1: Field Studies Section, Health Effects Research Laboratory, Environmental Protection Agency, Post Office Box 219, Wenatchee, Washington, 98801 2: National Center for Toxicological Research, Jefferson, Arkansas 3: Department of Epidemiology, School of Medicine, University of Miami, Miami, Florida; Source Info: May1977, Vol. 2 Issue 5, p1193; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15287397709529517
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sobotka, Thomas J.
AU - Brodie, Robert E.
AU - Spaid, Stephen L.
T1 - Tartrazine and the developing nervous system of rats.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1977/05//
VL - 2
IS - 5
M3 - Article
SP - 1211
EP - 1220
SN - 00984108
AB - Rat dams were exposed to the artificial food color tartrazine (FD&C Yellow no. 5) at dietary levels of 0, 1, and 2% during gestation and lactation. The experimental offspring were continued on the same diets for approximately 3 months after weaning. No adverse physical or behavioral effects were noted in the dams. Fetal development and postnatal viability of the offspring were also normal. The only effect on postnatal development of the central nervous system (CNS) was a small transient change in neuromotor clinging ability of female offspring. The limited effect of tartrazine on the CNS was further evidenced by the facts that (1) the neurobehavioral profiles of the experimental weanlings revealed no significant abnormalities, and (2) morphochemical analysis of brain tissue, as well as brain weights, revealed no abnormalities. Tartrazine did appear to exert more general signs of toxicity in the off spring‐namely, depressed body weight, an apparent reduction in thymus weight, and a slight elevation of red blood cells and hemoglobin. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75456863; Sobotka, Thomas J. 1 Brodie, Robert E. 2 Spaid, Stephen L. 2; Affiliation: 1: Division of Toxicology, Food and Drug Administration, Department of Health, Education, and Welfare, 200 C Street, S.W., Washington, D.C., 20204 2: Division of Toxicology, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C.; Source Info: May1977, Vol. 2 Issue 5, p1211; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397709529519
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moo-Penn, Winston F.
AU - Schmidt, Robert M.
AU - Jue, Danny L.
AU - Bechtel, Katherine C.
AU - Wright, Jane M.
AU - Horne III, McDonald K.
AU - Haycraft, Gordon L.
AU - Roth Jr., Eugene F.
AU - Nagel, Ronald L.
T1 - Hemoglobin S Travis: a Sickling Hemoglobin with Two Amino Acid Substitutions [β6(A3)Glutamic Acid → Valine and β142(H2O)Alanine → Valine].
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1977/08//8/1/77
VL - 77
IS - 3
M3 - Article
SP - 561
EP - 566
PB - Wiley-Blackwell
SN - 00142956
AB - Hb S Travis is a previously undescribed sickling hemoglobin with two amino acid substitutions in the β chain: β6 Glu→Val and β142 Ala→Val. The β6 Glu→Val mutation imparts to Hb S Travis the characteristic properties of sickling hemoglobin, namely its association with erythrocyte sickling, the insolubility of the hemoglobin in the reduced form, and a minimum gelling concentration value identical to Hb S. Unlike Hb S, Hb S Travis exhibits an increased oxygen affinity and a decreased affinity for 2,3-bisphosphoglycerate and inositol hexakisphosphate. In addition, the variant hemoglobin's tendency to autoxidize and its mechanical precipitability suggest that there are conformational differences between Hb S and Hb S Travis. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - AMINO acids
KW - ERYTHROCYTES
KW - BLOOD proteins
KW - GELATION
KW - INOSITOL
N1 - Accession Number: 13746195; Moo-Penn, Winston F. 1 Schmidt, Robert M. 1 Jue, Danny L. 1 Bechtel, Katherine C. 1 Wright, Jane M. 1 Horne III, McDonald K. 2 Haycraft, Gordon L. 2 Roth Jr., Eugene F. 3 Nagel, Ronald L. 3; Affiliation: 1: Hematology Division, Center for Disease Control, Public Health Service, Department of Health, Education, and Welfare, Georgia 2: David Grant Medical Center, Travis Air Force Base, California 3: Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, New York; Source Info: 8/1/77, Vol. 77 Issue 3, p561; Subject Term: HEMOGLOBIN; Subject Term: AMINO acids; Subject Term: ERYTHROCYTES; Subject Term: BLOOD proteins; Subject Term: GELATION; Subject Term: INOSITOL; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baer, Harold
AU - Hooton, Michael L.
AU - Dawson, Charles R.
AU - Lerner, D. I.
T1 - THE INDUCTION OF IMMUNE TOLERANCE IN DELAYED CONTACT SENSITIVITY BY THE USE OF CHEMICALLY RELATED SUBSTANCES OF LOW IMMUNOGENICITY.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/08//
VL - 69
IS - 2
M3 - Article
SP - 215
EP - 218
SN - 0022202X
AB - Immune tolerance in delayed contact sensitivity to pentadecylcatechol can be induced by a series of derivatives substituted in the 6 position of the ring. Some of these derivatives have the property of being very poor sensitizers and having very low dermal toxicity. Thus, sensitization and tolerance have different biologic mechanisms and are associated with different properties of these chemicals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGICAL tolerance
KW - CONTACT dermatitis
KW - CATECHOL
KW - IMMUNE system
KW - TOLERATION
KW - CHEMICALS
N1 - Accession Number: 12506329; Baer, Harold 1,2 Hooton, Michael L. 1,2 Dawson, Charles R. 1,2 Lerner, D. I. 1,2; Affiliation: 1: Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland. 2: Department of Chemistry, Columbia University, New York, New York, U. S. A.; Source Info: Aug77, Vol. 69 Issue 2, p215; Subject Term: IMMUNOLOGICAL tolerance; Subject Term: CONTACT dermatitis; Subject Term: CATECHOL; Subject Term: IMMUNE system; Subject Term: TOLERATION; Subject Term: CHEMICALS; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12506329
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fusillo, Alice E.
AU - Beloian, Arletta M.
T1 - Consumer Nutrition Knowledge and Self Reported Food Shopping Behavior.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/09//
VL - 67
IS - 9
M3 - Article
SP - 846
PB - American Public Health Association
SN - 00900036
AB - In 1975 a national sample of consumers was questioned about their knowledge of nutrition, beliefs about food, and their shopping behavior. Findings indicate a particular need for education related to facts about iron, thiamin, riboflavin, and vitamins A and D. Consumers with low knowledge tended to have less education, lower income, and less prestigious occupations. Of these variables, educational achievement level had the strongest association to low nutrition knowledge. Using an index based on the three socioeconomic variables, low knowledge was more often present among the male and older shoppers, with age having the stronger association. Association of the three indices of nutrition knowledge, food beliefs, and reported shopping behavior were found to be positive and linear. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMERS
KW - NUTRITION -- Study & teaching
KW - CONSUMER behavior
KW - GROCERY shopping
KW - FOOD consumption
KW - ACADEMIC achievement
KW - SOCIOECONOMICS
KW - SOCIAL surveys
KW - UNITED States
N1 - Accession Number: 5666997; Fusillo, Alice E. 1 Beloian, Arletta M. 1; Affiliation: 1: Division of Consumer Studies, Food and Drug Administration; Source Info: Sep77, Vol. 67 Issue 9, p846; Subject Term: CONSUMERS; Subject Term: NUTRITION -- Study & teaching; Subject Term: CONSUMER behavior; Subject Term: GROCERY shopping; Subject Term: FOOD consumption; Subject Term: ACADEMIC achievement; Subject Term: SOCIOECONOMICS; Subject Term: SOCIAL surveys; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horwitz, Marcus A.
AU - Pollard, Robert A.
AU - Merson, Michael H.
AU - Martin, Stanley M.
T1 - A Large Outbreak of Foodborne Salmonellosis On the Navajo Nation Indian Reservation, Epidemiology and Secondary Transmission.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1977/11//
VL - 67
IS - 11
M3 - Article
SP - 1071
PB - American Public Health Association
SN - 00900036
AB - In September 1974, the largest outbreak of foodbome salmonellosis ever reported to the Center for Disease Control—affecting an estimated 3,400 persons -occurred on the Navajo Nation Indian Reservation. The responsible agent was Salmonella newport and the vehicle of transmission was potato salad served to an estimated 11,000 persons at a free barbecue. The cooked ingredients of the potato salad had been stored for up to 16 hours at improper holding temperatures. The magnitude of the outbreak allowed us to study secondary transmission by calculating the rates of diarrheal illness during the 2 weeks following the outbreak in persons who did not attend the barbecue and by examining the results of stool cultures obtained after the outbreak. We found no secondary transmission. We conclude that a health official should monitor food preparation and service at large social gatherings and that person-to-person transmission of salmonellosis probably does not normally occur even in settings considered highly conducive to cross-infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA food poisoning
KW - FOOD poisoning
KW - FOODBORNE diseases
KW - SALMONELLA diseases
KW - EPIDEMICS
KW - PUBLIC health
KW - DIARRHEA
KW - COOKING (Potatoes)
KW - FOOD service
KW - TRANSMISSION
N1 - Accession Number: 5662347; Horwitz, Marcus A. 1 Pollard, Robert A. 1 Merson, Michael H. 1 Martin, Stanley M. 1; Affiliation: 1: Bacterial Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, GA 30333; Source Info: Nov77, Vol. 67 Issue 11, p1071; Subject Term: SALMONELLA food poisoning; Subject Term: FOOD poisoning; Subject Term: FOODBORNE diseases; Subject Term: SALMONELLA diseases; Subject Term: EPIDEMICS; Subject Term: PUBLIC health; Subject Term: DIARRHEA; Subject Term: COOKING (Potatoes); Subject Term: FOOD service; Subject Term: TRANSMISSION; NAICS/Industry Codes: 722330 Mobile Food Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Langner, A.
AU - Wolska, H.
AU - Marzulli, F. N.
AU - Jablonska, S.
AU - Jarzabek-Chorzelska, M.
AU - Glinski, W.
AU - Pawinska, M.
T1 - DERMAL TOXICITY OF 8-METHOXYPSORALEN ADMINISTERED (BY GAVAGE) TO HAIRLESS MICE IRRADIATED WITH LONG-WAVE ULTRAVIOLET LIGHT.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1977/11//
VL - 69
IS - 5
M3 - Article
SP - 451
EP - 457
SN - 0022202X
AB - Hairless mice were administered various amounts of 8-methoxypsoralen (8-MOP) by gavage, followed by irradiation with ultraviolet light (UVA) two or more times per week for periods ranging from 1 to 12 months. The minimum phototoxic dose was 20 mg/kg body weight by this route of administration and potential for serious organ toxicity in long-term exposures was investigated. No histologic features of cutaneous malignancy were encountered under test conditions which produced prolonged phototoxicity, deep ulceration, cicatrization, and other deformities. Repeated daily gavage doses of 20 mg psoralen/kg body weight in conjunction with twice weekly irradiation for 10 min with EVA elicited an erythematous phototoxic reaction, but did not give rise to subsequent skin lesions. 8-MOP in repeated daily gavage doses of 30 mg and 40 mg/kg body weight combined with twice weekly UVA irradiation for 10 min caused severe burning with subsequent scarring, but did not induce malignant tumors in experiments lasting 8 months. No organ toxicity was seen except for toxic liver changes when severe cutaneous burn and pronounced ulcerations were produced. Limited immunologic studies disclosed no abnormalities in this sytem. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - CUTANEOUS glands
KW - SKIN diseases
KW - MICE as laboratory animals
KW - IRRADIATION
KW - RADIATION
N1 - Accession Number: 12511300; Langner, A. 1,2 Wolska, H. 1,2 Marzulli, F. N. 1,2 Jablonska, S. 1,2 Jarzabek-Chorzelska, M. 1,2 Glinski, W. 1,2 Pawinska, M. 1,2; Affiliation: 1: Department of Dermatology, Warsaw Medical School, Warsaw, Poland. 2: Toxicology Division, Food and Drug Administration, Washington, D.C., U.S.A. (F.N.M.).; Source Info: Nov77, Vol. 69 Issue 5, p451; Subject Term: ULTRAVIOLET radiation; Subject Term: CUTANEOUS glands; Subject Term: SKIN diseases; Subject Term: MICE as laboratory animals; Subject Term: IRRADIATION; Subject Term: RADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1523-1747.ep12511300
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Overpeck, James G.
AU - Colson, Sylvia H.
AU - Hohmann, John R.
AU - Applestine, Marshall S.
AU - Reilly, Joseph F.
T1 - Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 785
EP - 803
SN - 00984108
AB - Radioimmunoassay (RIA) data on concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters have been collated from the literature. Few reports include data for both sexes, for age groups, or for more than one species. In selecting references for inclusion in the tables, efforts were made to choose data only from RIA procedures that were adequately validated. A number of similarities can be found by reviewing the tables. Levels of estradiol appear somewhat similar for humans, chimpanzees, and rhesus monkeys of both sexes. Among the notable differences are the levels of estradiol and progesterone in primates and rodents, the apparently high level of aldosterone in mice, and the patterns of progesterone secretion in mice and rats. All values in the tables have been converted to picograms for easy comparison between steroids and species. Data for humans are fairly complete, but there is a significant lack of information for several other species. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196189; Overpeck, James G. 1 Colson, Sylvia H. 2 Hohmann, John R. 2 Applestine, Marshall S. 2 Reilly, Joseph F. 2; Affiliation: 1: Division of Drug Biology, Bureau of Drugs, Food and Drug Administration, HFD‐412, Washington, D.C., 20204 2: Division of Drug Biology, Bureau of Drugs, Food and Drug Administration, Washington, D.C.; Source Info: Jan1978, Vol. 4 Issue 5/6, p785; Number of Pages: 19p; Document Type: Article
L3 - 10.1080/15287397809529700
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ong, Tong‐man
AU - Slade, Barbara
T1 - Mutagenicity and mutagenic specificity of metronidazole and niridazole in neurospora crassa.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1978/01/02/
VL - 4
IS - 5/6
M3 - Article
SP - 815
EP - 824
SN - 00984108
AB - Mutagenicity and mutagenic specificity of niridazole and metronidazole, two chemotherapeutic agents used in the treatment of human parasitic diseases, were studied with the ad‐3 test system of Neurospora crassa. The results show that neither compound is mutagenic in resting conidia. In growing vegetative cells, however, both compounds are mutagenic in N. crassa. Genetic analysis of the mutants indicated that niridazole induces predominantly base‐pair substitution mutations. None of the niridazole‐induced mutants resulted from multilocus deletions. The spectra of genetic alterations induced by metronidazole are similar to those induced by the mono‐functional alkylating agents ethyleneimine (El), ethylmethanesulfonate (EMS), and ICR‐177. It is therefore suggested that the mechanism of mutation induction by metronidazole in Neurospora is similar to that of monofunctional alkylating agents. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76196191; Ong, Tong‐man 1,2 Slade, Barbara 1; Affiliation: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 2: National Institute for Occupational Safety and Health, ALOSH, Morgantown, West Virginia, 26505; Source Info: Jan1978, Vol. 4 Issue 5/6, p815; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287397809529702
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leong, D.
AU - Coe, J.E.
T1 - Metabolism of homologous and heterologous serum proteins in garter snakes ( Thamnophis ordinoides ).
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 931
EP - 937
PB - Wiley-Blackwell
SN - 00192805
AB - The half life (T½) of serum immunoglobulin (Ig) and albumin from snakes and mammals were determined in both garter snakes (Thamnophis ordinoides) and mice (Mus musculus). Metabolism of serum proteins in snakes was similar to mammalian protein metabolism in that homologous serum albumin had shorter T½ (16 days) than IgG (38 days). Also, reptilian and mammalian serum proteins had a relatively longer T½ when injected into closely related species. Thus mammalian serum Ig (rabbit gamma globulin (RGG)) had a shorter T½ (6.3 days) in snake than did homologous snake IgG (38 days), whereas in mice, RGG had a longer T½ (3.8 days) than snake Ig (0.9 days). Differences between metabolism of homologous and heterologous albumins were apparent only in snakes in which the T½. of homologous albumin was approximately 8-fold greater than mammalian albumin. These results indicate that metabolism of both Ig and albumin in snakes is regulated by specific receptors whereas albumin receptors have been difficult to demonstrate in mammals. The results of this study suggest that one of the factors determining the metabolism of a protein is its foreignness to the host perhaps because of receptor cross reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD proteins
KW - GARTER snakes
KW - THAMNOPHIS ordinoides
KW - IMMUNOGLOBULINS
KW - PROTEIN metabolism
KW - MAMMALS
KW - SERUM
KW - ALBUMINS
N1 - Accession Number: 13930713; Leong, D. 1 Coe, J.E. 1; Affiliation: 1: Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Moutain Laboratory, Hamilton, Montana, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p931; Subject Term: BLOOD proteins; Subject Term: GARTER snakes; Subject Term: THAMNOPHIS ordinoides; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEIN metabolism; Subject Term: MAMMALS; Subject Term: SERUM; Subject Term: ALBUMINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Johannesen, Lynne
AU - Inman, J.K.
AU - Merchant, B.
T1 - Specificity of murine delayed-type hypersensitivity to conjugates of large or small haptens on protein carriers bearing lipid groups.
JO - Immunology
JF - Immunology
Y1 - 1978/05//
VL - 34
IS - 5
M3 - Article
SP - 947
EP - 954
PB - Wiley-Blackwell
SN - 00192805
AB - Delayed-type hypersensitivity (DH) in the mouse was provoked with different haptencarrier complexes mixed with the cationic, surfaceactive lipid, dimethyl dioctadecyl ammonium bromide (DDA). DH was measured as footpad swelling.Conjugates of bovine serum albumin (BSA) with the small haptens dinitrophenyl (DNP), 'arsonate'(ARS) and 'sulphonate' (SULPH) served to generate strong DH reactions towards the homologous antigen. Insertion of a tripeptide spacer between the hapten and carrier resulted in lower DH reactivity. Optimal dosages and optimal time intervals between sensitization and DH elicitation were determined for the enlarged hapten-carrier complexes. Cyclophosphamide (CY) treatment, before priming with complexes mixed with DDA, caused a 5-6 day delay in the expression of DH but failed to evoke enhanced DH for any of the antigens tested. A broad array of cross reactions between small and enlarged hapten-carrier complexes showed a relative lack of specificity in these DH responses. The results are compared with others reported in the literature and are explained mainly by the effects of electrostatically bound lipid groups of DDA in the sensitizing conjugates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DELAYED hypersensitivity
KW - MICE
KW - SERUM albumin
KW - HAPTENS
KW - ANTIGENS
KW - CARRIER proteins
KW - BROMIDES
N1 - Accession Number: 13932691; Snippe, H. 1 Johannesen, Lynne 1 Inman, J.K. 1 Merchant, B. 1; Affiliation: 1: Division and Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: May78, Vol. 34 Issue 5, p947; Subject Term: DELAYED hypersensitivity; Subject Term: MICE; Subject Term: SERUM albumin; Subject Term: HAPTENS; Subject Term: ANTIGENS; Subject Term: CARRIER proteins; Subject Term: BROMIDES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eiermann, Heinz J.
T1 - Cosmetic regulatory activities in the United States: past, present and future.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1978/06//
VL - 4
IS - 3
M3 - Article
SP - 157
EP - 164
SN - 01051873
AB - To protect consumers from unsafe or deceptively labeled cosmetics, the Food and Drug Administration promulgates regulations, conducts factory inspections. investigates marketed products, evaluates consumer complaints, maintains registries of voluntarily submitted formulation and advent reaction information, and carries out analytical, microbiological and toxicological studies. There has been a significant shift in program priorities from surveillance activities to scientific research and the determination of systemic hazards to health. Major scientific efforts involve studies to determine the dermal toxicity of cosmetics, develop methods for predicting the efficacy of preservatives, and answer questions about the skin penetration and carcinogenicity of nitrosodiethanolamine. A further issue of concern is the carcinogenic hazard of hair dyes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COSMETICS
KW - CONSUMERS
KW - COSTUME
KW - STRUGGLE
KW - UNITED States
KW - Contact dermatitis
KW - cosmetic
KW - hair dyes
KW - mascaras
KW - nitrosoamines
KW - regulatory.
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 12214119; Eiermann, Heinz J. 1; Affiliation: 1: Division of Cosmetics Technology, Bureau of Foods, Food and Drug Administration, Washington, D.C., USA.; Source Info: 1978, Vol. 4 Issue 3, p157; Subject Term: COSMETICS; Subject Term: CONSUMERS; Subject Term: COSTUME; Subject Term: STRUGGLE; Subject Term: UNITED States; Author-Supplied Keyword: Contact dermatitis; Author-Supplied Keyword: cosmetic; Author-Supplied Keyword: hair dyes; Author-Supplied Keyword: mascaras; Author-Supplied Keyword: nitrosoamines; Author-Supplied Keyword: regulatory.; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 448199 All other clothing stores; NAICS/Industry Codes: 448190 Other Clothing Stores; NAICS/Industry Codes: 315280 Other Cut and Sew Apparel Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1600-0536.ep12214119
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Merchant, B.
AU - Johannessen, L.
AU - Inman, J. K.
T1 - Effects of cyclophosphamide on the in vivo response of outbred athymic (nude) mice to a thymus-independent antigen (DNP-AGG-Ficoll).
JO - Immunology
JF - Immunology
Y1 - 1978/12//
VL - 35
IS - 6
M3 - Article
SP - 1009
EP - 1015
PB - Wiley-Blackwell
SN - 00192805
AB - Both nude mice (nu/nu) and their heterozygous littermates (nu/+) were injected with a single IP dose of 300 mg cyclophosphamide (CY)/kg. CY is a known immunosuppressive agent, which affects primarily B lymphocytes. Immunization with the thymus independent antigen DNP-AGG59- Ficoll after CY treatment disclosed that restoration of the primary direct PFC response occurred more rapidly in nude mice than in nu/+ mice. However in these same experiments, the primary indirect PFC response, recovered earlier in nu/+ mice than in nude mice. After CY treatment, secondary indirect PFC responses were delayed in both nude and nu/+ mice, but the greatest effect was seen in nude mice. The data suggest that the presence of T cells has little if any influence on the recovery capacity of those B cells which are destined to become direct PFC. However the recovery of B cells which are destined to produce indirect PFC responses is facilitated by the presence of T cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOTHERAPY
KW - THYMUS
KW - ANTIGENS
KW - FICOLL
KW - LYMPHOCYTES
KW - B cells
KW - T cells
KW - ANTIGEN presenting cells
N1 - Accession Number: 15789199; Snippe, H. 1,2 Merchant, B. 1,2 Johannessen, L. 1,2 Inman, J. K. 1,2; Affiliation: 1: Division of Blood and Blood Products, Bureau of Biologies, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20014 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014; Source Info: Dec78, Vol. 35 Issue 6, p1009; Subject Term: IMMUNIZATION; Subject Term: IMMUNOTHERAPY; Subject Term: THYMUS; Subject Term: ANTIGENS; Subject Term: FICOLL; Subject Term: LYMPHOCYTES; Subject Term: B cells; Subject Term: T cells; Subject Term: ANTIGEN presenting cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Halperin, Jerome A.
T1 - Effects of Written Drug Information on Patient Knowledge and Compliance: A Literature Review.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/01//
VL - 69
IS - 1
M3 - Article
SP - 47
PB - American Public Health Association
SN - 00900036
AB - Abstract: The prospect of patient-oriented prescription drug labeling has focused increased attention on the effectiveness of written information for the consumer. Studies which have evaluated the effects of written prescription drug information in a patient population are reviewed. Several studies indicate that written information can be effective in improving patient compliance with regimens for antibiotic therapy. However, for drugs used on a long-term basis, written information as a sole intervention has not been shown to be sufficient for improving patient compliance. Patient knowledge of less commonly known information, such as precautions, side effects, or special directions is frequently improved by written information. Listing a drug's side effects has not been shown to increase the reported experience of side effects; however, one study suggests that patients may be more willing to report side effects to a health professional if they are listed in the written information. The trend for recent studies has been to focus on the "milieu" in which written information is provided or to systematically vary structural features of the information in order to improve the quality of drug communications. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Side effects
KW - DRUGS -- Physiological effect
KW - PATIENT compliance
KW - HEALTH behavior
KW - ANTI-infective agents
KW - ANTIBACTERIAL agents
KW - ANTIBIOTICS
KW - PROSPECTING -- Costs
KW - DISEASES -- Causes & theories of causation
KW - REPORTING
N1 - Accession Number: 6007861; Morris, Louis A. 1 Halperin, Jerome A. 2; Affiliation: 1: Technical Information Specialist (Social Sciences), Bureau of Drugs, HFD-107, Food and Drug Administration, Rockville, MD 20857. 2: Deputy Associate Director, Bureau of Drugs, FDA.; Source Info: Jan1979, Vol. 69 Issue 1, p47; Subject Term: DRUGS -- Side effects; Subject Term: DRUGS -- Physiological effect; Subject Term: PATIENT compliance; Subject Term: HEALTH behavior; Subject Term: ANTI-infective agents; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTIBIOTICS; Subject Term: PROSPECTING -- Costs; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: REPORTING; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pitha, Josef
AU - Kociolek, Karol
AU - Caron, Marc G.
T1 - Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1979/02/15/
VL - 94
IS - 1
M3 - Article
SP - 11
EP - 18
PB - Wiley-Blackwell
SN - 00142956
AB - Residues of Triton X-100 [C8H17-C6H4-(O-CH2-CH2)9-10-O-] were bound by ether bonds to inulin, dextran, amylose, and cellulose-yielding compounds containing 10- 30, 5, 19 and 6% (w/w) of Triton X-100 residue respectively. The water-soluble inulin derivative was studied in detail. This compound was fractionated on the basis of molecular weight by gel chromatography and on the basis of degree of substitution by adsorption to polystyrene resin. Even the residues of Triton X-100 which were bound to a single inulin macromolecule were able to form a micelle; in addition to these monomolecular micelles the inulin derivative was able to form polymolecular micelles as well. The inulin derivative was effective in solubilizing proteins and phospholipids from membranes of human erythrocytes and liberated reverse transcriptase activity from the membrane-enveloped virions of murine leukemia. The Triton X-100 inulin derivative abolished binding of the ³H-labelled antagonist dihydroalprenolol to solubilized preparations of β-adrenergic receptors from frog erythrocytes in a dose-related manner similar to the inactivation produced by Triton X-100, while digitonin, a detergent containing a bulkier hydrophobic group, did not cause inactivation. On the basis of its Triton X-100 content, the inulin derivative was found to be less detrimental to the growth of murine erythroleukemic cells in vitro than Triton X-100 alone when short (2-4 h) exposures were used, but this difference disappeared at longer (1-3 day) exposures. Results thus suggest that the increase in size of the hydrophilic part of the detergent brings about moderation in those effects of the detergent which are dependent on the rate of diffusion, while the solubilizing and inactivating effects of the detergent were not changed. It is probably the size of the hydrophobic part which is important in protein-inactivating properties of the detergent. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - CARBOHYDRATES
KW - LEUKEMIA
KW - CLEANING compounds
KW - PROTEINS
KW - CANCER
KW - LABELING
N1 - Accession Number: 13605068; Pitha, Josef 1 Kociolek, Karol 2 Caron, Marc G. 3; Affiliation: 1: Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland. 2: Baltimore City Hospitals, Baltimore, Maryland. 3: Department of Medicine, Duke University Medical Center, Durham, North Carolina.; Source Info: 2/15/79, Vol. 94 Issue 1, p11; Subject Term: POLYSACCHARIDES; Subject Term: CARBOHYDRATES; Subject Term: LEUKEMIA; Subject Term: CLEANING compounds; Subject Term: PROTEINS; Subject Term: CANCER; Subject Term: LABELING; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Middaugh, John P.
T1 - Side Effects of Diptheria-Tetanus Toxoid in Adults .
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/03//
VL - 69
IS - 3
M3 - Article
SP - 246
PB - American Public Health Association
SN - 00900036
AB - Abstract: During a mass diphtheria-tetanus immunization campaign in November 1975, more than 220,000 doses of diphtheria-tetanus toxoid, adult type were administered to adults throughout Alaska. In Anchorage, where more than 87,000 doses were given, a survey was conducted to determine the frequency of side effects. Postcard questionnaires were mailed to 2,000 randomly selected Anchorage residents: 467 questionnaires were returned by the post office as undeliverable, and 697 questionnaires were completed and returned. A follow-up survey was done of a random sample of the 836 non-responders. Of those responding, 57.8 per cent reported at least one reaction to the toxoids. The most frequent side effects were sore arm (42.7 per cent), swelling at the site of injection (34.8 per cent), and itching (24.2 per cent). Serious side effects occurred less frequently--swelling of the arm below the elbow (1.1 per cent) and abscess or infection (0.7 per cent). Of those vaccinated, 0.5 per cent saw a physician. There were no statistically significant differences in reaction rates by age group, except for sore arms. The jet injector produced more arm swelling at the site of injection, hives, and itching. More women than men reported adverse reactions, especially sore arm, swelling at the site of injection, and itching. Fear of adverse side effects should not preclude mass vaccination of adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETANUS
KW - DIPHTHERIA -- Vaccination
KW - CORYNEBACTERIUM diseases
KW - IMMUNIZATION
KW - DRUGS -- Side effects
KW - QUESTIONNAIRES
KW - SURVEYS
KW - ALASKA
KW - UNITED States
N1 - Accession Number: 6005908; Middaugh, John P. 1; Affiliation: 1: Field Services Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, DHEW, Atlanta GA 30333; Source Info: Mar1979, Vol. 69 Issue 3, p246; Subject Term: TETANUS; Subject Term: DIPHTHERIA -- Vaccination; Subject Term: CORYNEBACTERIUM diseases; Subject Term: IMMUNIZATION; Subject Term: DRUGS -- Side effects; Subject Term: QUESTIONNAIRES; Subject Term: SURVEYS; Subject Term: ALASKA; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colligan, Michael J.
AU - Murphy, Lawrence R.
T1 - Mass psychogenic illness in organizations: An overview.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1979/06//
VL - 52
IS - 2
M3 - Article
SP - 77
EP - 90
PB - Wiley-Blackwell
SN - 03058107
AB - Published and unpublished reports of mass psychogenic illness, defined as the collective occurrence of physical symptoms and related beliefs among two or more persons in the absence of an identifiable pathogen, are reviewed with particular emphasis on organizational occurrences. A number of factors (e.g. boredom, sex-role identification, interpersonal conflict, physical stress) are identified as potential precipitating conditions, and the contagion of symptoms is discussed in terms of the convergence-contagion dichotomy in collective behaviour suggested by Milgram & Toch (1969). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL illness
KW - MENTAL fatigue
KW - CONFLICT (Psychology)
KW - SOCIAL psychology
KW - INTERPERSONAL conflict
KW - COLLECTIVE behavior
N1 - Accession Number: 6293742; Colligan, Michael J. 1 Murphy, Lawrence R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, US Department of Health, Education and Welfare.; Source Info: Jun79, Vol. 52 Issue 2, p77; Subject Term: MENTAL illness; Subject Term: MENTAL fatigue; Subject Term: CONFLICT (Psychology); Subject Term: SOCIAL psychology; Subject Term: INTERPERSONAL conflict; Subject Term: COLLECTIVE behavior; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wardlaw, A. C.
AU - Parton, R.
AU - Bergman, R. K.
AU - Munoz, J. J.
T1 - Loss of adjuvanticity in rats for the hyperacute form of allergic encephalomyelitis and for reaginic antibody production in mice of a phenotypic variant of Bordetella pertussis .
JO - Immunology
JF - Immunology
Y1 - 1979/07//
VL - 37
IS - 3
M3 - Article
SP - 539
EP - 545
PB - Wiley-Blackwell
SN - 00192805
AB - The adjuvanticity of a phenotypic (C-mode) variant of B. pertussis, known to be deficient in certain immunological and physiopathological properties, was compared to that of the normal (X-mode) strain. The X-mode vaccine was a potent adjuvant for induction of hyperacute experimental allergic encephalomyelitis to guinea-pig spinal cord in Lewis rats whereas C-mode vaccine was inactive. X-mode vaccine was also highly active in the induction of reaginic (both IgE and IgG1) antibodies to ovalbumin in mice while C-mode vaccine caused only a transitory increase in the IgE level. These data support the view that an adjuvant component of B. pertussis, which is probably identical with the histamine-sensitizing and leukocytosis promoting factor, is much diminished in C-mode cells while the lipopolysaccharide adjuvant remains unchanged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGICAL adjuvants
KW - BIOLOGICAL response modifiers
KW - PREVENTIVE medicine
KW - IMMUNOGLOBULINS
KW - BORDETELLA pertussis
KW - ALLERGIC encephalomyelitis
KW - AUTOIMMUNE diseases
N1 - Accession Number: 13988628; Wardlaw, A. C. 1 Parton, R. 1 Bergman, R. K. 2 Munoz, J. J. 1; Affiliation: 1: Microbiology Department, Glasgow University, Glasgow 2: United States Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A.; Source Info: Jul79, Vol. 37 Issue 3, p539; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: BIOLOGICAL response modifiers; Subject Term: PREVENTIVE medicine; Subject Term: IMMUNOGLOBULINS; Subject Term: BORDETELLA pertussis; Subject Term: ALLERGIC encephalomyelitis; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daugharty, H.
AU - Kelley, K.
AU - Moore, C.
AU - Hersh, T.
T1 - Autoimmune implications of immune complexes in clinical variants of hepatitis B.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1979/08//
VL - 37
IS - 2
M3 - Article
SP - 213
EP - 220
PB - Wiley-Blackwell
SN - 00099104
AB - Immune complexes (IC) were investigated in sera from 208 individuals with various clinical types of viral hepatitis diagnosed by clinical and laboratory criteria, including liver biopsy. Immune complexes were assessed by platelet aggregation (P1 A) and by radioimmunoassay (RIA). The data were related to autoimmune phenomena (especially rheumatoid factors) and to the role that the IgM class to hepatitis B (HB) antibody might have in IC formation. Although the highest frequency of PI A was in the few sera from patients with cirrhosis or hepatoma, the next highest was in sera from acute hepatitis patients (71%), and the lowest in sera from chronic active (57%) and chronic persistent (46%) hepatitis patients. A proportional number of patients with IC's were positive for hepatitis B surface antigen (HBs). A parallel prevalence was noted between PI A and autoantibodies, with anti-Ig's being found more frequently in sera from acute hepatitis and chronic active hepatitis patients. The relationship between RIA results for complexes and RIA results for anti-IgG was inverse, as though anti-IgG interfered with IC reactivity by RIA. Anti-lgM pre-incubated with sera increased the amount of PI A in sera from patients with acute hepatitis as well as in those from patients with chronic persistent hepatitis, suggesting a more frequent IgM involvement in IC's in these diseases than in chronic active hepatitis. Whereas liver cell damage in acute and active hepatitis may reflect elevated autoantibodies, the IgM class of HBs antibody may be involved in acute as well as chronic persistent hepatitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B
KW - AUTOIMMUNE diseases
KW - IMMUNE complexes
KW - RADIOIMMUNOASSAY
KW - CHRONIC active hepatitis
KW - AUTOANTIBODIES
N1 - Accession Number: 16434598; Daugharty, H. 1 Kelley, K. 1 Moore, C. 2 Hersh, T. 2; Affiliation: 1: Diagnostic Products Evaluation Branch, Biological Products Division, Bureau of Laboratories, Center for Disease Control, Public Health Service, US Department of Health, Education and Welfare, Atlanta. 2: Department of Gastroenterology, Emory University Clinic and Emory University School of Medicine,Atlanta, Georgia 30322, USA.; Source Info: Aug1979, Vol. 37 Issue 2, p213; Subject Term: HEPATITIS B; Subject Term: AUTOIMMUNE diseases; Subject Term: IMMUNE complexes; Subject Term: RADIOIMMUNOASSAY; Subject Term: CHRONIC active hepatitis; Subject Term: AUTOANTIBODIES; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Halperin, William
AU - Weiss, William I.
AU - Altman, Ronald
AU - Diamond, Michael A.
AU - Black, Kenneth J.
AU - Laci, Alfred W.
AU - Black, Henry C.
AU - Goldfield, Martin
T1 - A Comparison of the Intradermal and Subcutaneous Routes of Influenza Vaccination with A/New Jersey/76 (Swine Flu) and A/Victoria/75: Report of a Study and Review of the Literature.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1979/12//
VL - 69
IS - 12
M3 - Article
SP - 1247
EP - 1251
PB - American Public Health Association
SN - 00900036
AB - Abstract: A trial of influenza vaccination, with use of bivalent split virus vaccine (A/New Jersey/76 and A/ Victoria/75), was conducted to compare the immunogenicity and reactions when vaccine was given by the subcutaneous and intradermal routes. Volunteers 18 to 24 years old were randomized into equal groups, one group receiving 0.1 ml of vaccine intradermally and the other receiving 0.5 ml subcutaneously. For the A/ Victoria vaccine, the immunogenicity of the intra dermal route seemed superior; for A/New Jersey vaccine, the routes were equivalent. Adverse reactions were minimal and equivalent for both groups. In times of vaccine shortage, the intradermal route is considered to stretch vaccine supplies. Field trials of new influenza vaccines should include evaluation of the immunogenicity of and adverse reactions caused by the same vaccine given by different routes in varied dosages. (Am J Public Health 69:1247-1250, 1979.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases
KW - CLINICAL trials
KW - PUBLIC health
KW - INFLUENZA -- Vaccination
KW - IMMUNOLOGY
N1 - Accession Number: 5981594; Halperin, William 1 Weiss, William I. 2 Altman, Ronald 3 Diamond, Michael A. 4,5 Black, Kenneth J. 4,5 Laci, Alfred W. 4,5 Black, Henry C. 4,5 Goldfield, Martin 4,5; Affiliation: 1: Medical Officer, National Institute for Occupational Safety and Health, CDC, Cincinnati, OH. 2: Chief, Allergy Section, Department of Medicine, St. Barnabas Medical Center. 3: New Jersey State Department of Health, P.O. Box 1540, Trenton, NJ 08625. 4: St. Barnabas Medical Center, Livington, NJ. 5: Division of Laboratories and Epidemiology, New Jersey State Department of Health.; Source Info: Dec1979, Vol. 69 Issue 12, p1247; Subject Term: COMMUNICABLE diseases; Subject Term: CLINICAL trials; Subject Term: PUBLIC health; Subject Term: INFLUENZA -- Vaccination; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eiermann, Heinz J.
T1 - Regulatory issues concerning AETT and 6-MC.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1980/01/02/
VL - 6
IS - 2
M3 - Article
SP - 120
EP - 122
SN - 01051873
AB - Acetylethyltetramethyltetralin, a widely used synthetic fragrance material, was found to cause neurotoxic effects in animals. 6-Methylcoumarin, another fragrance material, was determined to be a photocontact allergen. Insufficient information on their usage, consumer exposure and likely hazard to human health under conditions of use impair regulatory decisions. FDA's ability to protect consumers against a health hazard is greatly influenced by the availability of such data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ODORS
KW - HEALTH
KW - DISEASES
KW - CONSUMERS
KW - PHOTOSENSITIVITY disorders
KW - ALLERGENS
KW - 6-MC
KW - 6-methylcoumarin
KW - Acetylethyltetramethyltetralin
KW - AETT
KW - fragrance material
KW - regulatory.
N1 - Accession Number: 12190310; Eiermann, Heinz J. 1; Affiliation: 1: Division of Cosmetics Technology, Bureau of Foods, Food and Drug Administration, Washington, D.C., U.S.A.; Source Info: 1980, Vol. 6 Issue 2, p120; Subject Term: ODORS; Subject Term: HEALTH; Subject Term: DISEASES; Subject Term: CONSUMERS; Subject Term: PHOTOSENSITIVITY disorders; Subject Term: ALLERGENS; Author-Supplied Keyword: 6-MC; Author-Supplied Keyword: 6-methylcoumarin; Author-Supplied Keyword: Acetylethyltetramethyltetralin; Author-Supplied Keyword: AETT; Author-Supplied Keyword: fragrance material; Author-Supplied Keyword: regulatory.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1600-0536.ep12190310
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marzulli, Francis N.
AU - Maibach, Howard I.
T1 - Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1980/01/02/
VL - 6
IS - 2
M3 - Article
SP - 131
EP - 133
SN - 01051873
AB - Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was shown to be a more effective vehicle than petrolatum, when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk-benefit judgments is discussed briefly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - ODORS
KW - VEHICLES
KW - FATS & oils
KW - TRANSFER factor (Immunology)
KW - PETROLATUM
KW - Contact sensitization
KW - dose-response effects
KW - fragrance ingredients
KW - human predictive tests
KW - vehicles.
N1 - Accession Number: 12190332; Marzulli, Francis N. 1 Maibach, Howard I. 2; Affiliation: 1: Food and Drug Administration, Washington, D.C. 2: San Francisco Medical Center, Department of Dermatology, San Francisco, CA, U.S.A.; Source Info: 1980, Vol. 6 Issue 2, p131; Subject Term: CONTACT dermatitis; Subject Term: ODORS; Subject Term: VEHICLES; Subject Term: FATS & oils; Subject Term: TRANSFER factor (Immunology); Subject Term: PETROLATUM; Author-Supplied Keyword: Contact sensitization; Author-Supplied Keyword: dose-response effects; Author-Supplied Keyword: fragrance ingredients; Author-Supplied Keyword: human predictive tests; Author-Supplied Keyword: vehicles.; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; NAICS/Industry Codes: 324190 Other petroleum and coal product manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1600-0536.ep12190332
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Willers, J. M. N.
AU - Inman, J. K.
AU - Merchant, B.
T1 - The specificity of antibody formation in mice following immunization with hapten-carrier complexes mixed with the surfactant, dimethyl dioctadecyl ammonium bromide.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 361
EP - 366
PB - Wiley-Blackwell
SN - 00192805
AB - Mice were immunized i.e. with various enlarged haptens conjugated to bovine serum albumin and mixed with the cationic, surface active lipid, dimethyl dioctadecyl ammonium bromide (DDA). This immunization generated delayed-type hypersensitivity (DH) in these mice without detectable concomitant antibody formation. The DH was measured as footpad swelling. However, both direct and indirect hapten-specific PFC could be detected in peripheral lymph nodes and in spleens 4 days after a challenge injection. Although the adjuvant, DDA, promotes a strong cross-reactivity in DH between heterologous hapten--carrier complexes, the antibody-forming cells produced 4 days after challenge showed relatively high specificity for the immunizing hapten. This indicates only weak cross-reactivity at the anti-body-forming cell level co-existent with high cross-reactivity in DH expression to the same hapten-carrier complexes. These results are consistent with the possibility that B-cell receptors may be capable of expressing a greater degree of hapten specificity than T-cell receptors. It is tentatively concluded that Thelper cells participating in antibody formation may represent a subset of the T cells involved in DH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - IMMUNOGLOBULINS
KW - HAPTENS
KW - SURFACE active agents
KW - SERUM albumin
KW - MICE as laboratory animals
N1 - Accession Number: 13520411; Snippe, H. 1 Willers, J. M. N. 1 Inman, J. K. 2 Merchant, B. 3; Affiliation: 1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands. 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health. 3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p361; Subject Term: IMMUNIZATION; Subject Term: IMMUNOGLOBULINS; Subject Term: HAPTENS; Subject Term: SURFACE active agents; Subject Term: SERUM albumin; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Johannesen, L.
AU - Lizzio, Elaine
AU - Merchant, B.
T1 - Variable expression of delayed hypersensitivity in different mouse strains using dimethyl dioctadecyl ammonium bromide as an adjuvant.
JO - Immunology
JF - Immunology
Y1 - 1980/03//
VL - 39
IS - 3
M3 - Article
SP - 399
EP - 405
PB - Wiley-Blackwell
SN - 00192805
AB - Delayed-type hypersensitivity measured as footpad swelling was studied in a large number of inbred mouse strains. A conjugate of bovine serum albumin (BSA) with the small 2.4-dinitrophenyl (DNP) hapten served to generate strong reactions, specific for the DNP group. Delayed hypersensitivity was produced with the DNP-BSA complex mixed with the cationic, surface active lipid. dimethyl dioctadecyl ammonium bromide (DDA). Great variation was observed in delayed hypersensitivity among different mouse strains. For convenience, the mice were classified into five groups, notably: non-, low, moderate, good and high responders. The highest responding animals were HALB/cJ mice, the lowest were PJJN and outbred nu/nu mice. No correlation was observed between 1-1-2 type and the intensity of the elicited reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - SERUM albumin
KW - DINITROBENZENES
KW - HAPTENS
KW - IMMUNOLOGY
KW - MICE as laboratory animals
N1 - Accession Number: 13520532; Snippe, H. 1 Johannesen, L. 1 Lizzio, Elaine 1 Merchant, B. 1; Affiliation: 1: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration. Bethesda, Maryland, U.S.A.; Source Info: Mar1980, Vol. 39 Issue 3, p399; Subject Term: ALLERGY; Subject Term: SERUM albumin; Subject Term: DINITROBENZENES; Subject Term: HAPTENS; Subject Term: IMMUNOLOGY; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Meecham, William C.
AU - Shaw, Neil
AU - Frerichs, Ralph R.
AU - Coulson, Anne Hersey
AU - Stenvig, Thomas E.
AU - Brosseau, James D.
AU - Bader, Max
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/05//
VL - 70
IS - 5
M3 - Letter
SP - 543
PB - American Public Health Association
SN - 00900036
AB - Several letters to the editor are presented in response to articles in previous issues including one on "Los Angeles Airport Noise and Mortality: Faulty Analysis and Public Policy," "Diabetes Among the Three Affiliated Tribes: Correlation with Degree of Indian Inheritance," in the December 1979 issue, and another one on the intradermal and subcutaneous routes of influenza vaccination.
KW - LETTERS to the editor
KW - AIRPORT noise
KW - DIABETES
KW - INFLUENZA
KW - VACCINATION
N1 - Accession Number: 4954578; Meecham, William C. 1 Shaw, Neil Frerichs, Ralph R. 2 Coulson, Anne Hersey 3 Stenvig, Thomas E. 4 Brosseau, James D. 5 Bader, Max; Affiliation: 1: Professor, Mechanics and Structures Department, University of California, Los Angeles School of Engineering & Applied Science Los Angeles, CA 90024 2: Assistant Professor, Division of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90024 3: Research Epidemiologist, Division of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90024 4: Deputy Chief, Area Nursing Branch, Aberdeen Area Indian Health Service, Federal Building, Aberdeen, SD S7401 5: Associate Professor, Dept. of Community Medicine, University of North Dakota, Grand Forks, ND 58201; Source Info: May80, Vol. 70 Issue 5, p543; Subject Term: LETTERS to the editor; Subject Term: AIRPORT noise; Subject Term: DIABETES; Subject Term: INFLUENZA; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenstein, David I.
AU - Joseph, Lireka P.
AU - MacKenzie, Leslie J.
AU - Wyden, Ron
T1 - Professional Encroachment: A Comparison of the Emergence of Denturists in Canada and Oregon.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/06//
VL - 70
IS - 6
M3 - Article
SP - 614
PB - American Public Health Association
SN - 00900036
AB - In 1978, supporters of denturism in Oregon succeeded in passing an initiative which allows denturists to provide dentures directly to the public. The steps which led to the referendum included three unsuccessful attempts to have the state legislature enact a law legalizing denturism, After capturing broad-based consumer support, the issue was placed on the ballot and passed by an overwhelming margin. Both the denturists and the dentists in Oregon adopted strategies similar to those used in Canada over 20 years ago when the issue was raised in a number of provinces. As was the case in Canada, the denturists prevailed. Denturists stressed the price differential and the issue of freedom of choice. Dentists stressed health and safety issues. The public perceived the dentists' campaign as negative and self-serving. This perception may have contributed to the election results. In order to avoid this tarnished image, dentists must anticipate the public's needs, and formulate strategies to meet such needs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTURES
KW - DENTAL care
KW - DENTISTS
KW - CANADIAN provinces
KW - LEGISLATIVE bodies
KW - LEGISLATION
KW - OREGON
KW - CANADA
KW - UNITED States
N1 - Accession Number: 4954760; Rosenstein, David I. 1 Joseph, Lireka P. 2 MacKenzie, Leslie J. 3 Wyden, Ron 4; Affiliation: 1: Associate Professor and Chairman, Department of Public Health Dentistry, School of Dentistry, University of Oregon, Health Sciences Center, 611 S.W. Campus Drive, Portland, OR 97201 2: Medical Radiation Specialist, Food and Drug Administration, DHEW 3: Assistant Professor, Department of Public Health Dentistry 4: Co-Director, Oregon Gray Panthers; Source Info: Jun80, Vol. 70 Issue 6, p614; Subject Term: DENTURES; Subject Term: DENTAL care; Subject Term: DENTISTS; Subject Term: CANADIAN provinces; Subject Term: LEGISLATIVE bodies; Subject Term: LEGISLATION; Subject Term: OREGON; Subject Term: CANADA; Subject Term: UNITED States; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 921120 Legislative Bodies; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sacks, Jeffrey J.
AU - Krushat, Mark
AU - Newman, Jeffrey
T1 - Reliability of the Health Hazard Appraisal.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1980/07//
VL - 70
IS - 7
M3 - Article
SP - 730
PB - American Public Health Association
SN - 00900036
AB - Abstract: As part of a controlled clinical trial of Health Hazard Appraisal's (HHA) efficacy in stimulating risk reduction, the reliability of the HHA questionnaire was evaluated. Of 203 subjects, only 30 (15 per ¢) had no contradictions when comparing the responses of the follow-up with baseline questionnaire. Overall, there was an average of 1.6 contradictions per subject. Failure to control for reliability may account for apparent reduction of risk reported in previous studies of HHA. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - RELIABILITY (Personality trait)
KW - PUBLIC health
KW - PREVENTIVE medicine
KW - CLINICAL medicine -- Research
KW - STATISTICAL reliability
KW - MEDICAL research
KW - CLINICAL trials
KW - MEDICAL care
N1 - Accession Number: 4954406; Sacks, Jeffrey J. 1 Krushat, Mark 2 Newman, Jeffrey 3; Affiliation: 1: Public Health Service Hospital, San Francisco. 2: Biostatistician, Research Coordination Branch. 3: Chairman, Department of Preventive Medicine.; Source Info: Jul1980, Vol. 70 Issue 7, p730; Subject Term: HEALTH risk assessment; Subject Term: RELIABILITY (Personality trait); Subject Term: PUBLIC health; Subject Term: PREVENTIVE medicine; Subject Term: CLINICAL medicine -- Research; Subject Term: STATISTICAL reliability; Subject Term: MEDICAL research; Subject Term: CLINICAL trials; Subject Term: MEDICAL care; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olenchock, S. A.
AU - Mull, J. C.
AU - Major, P. C.
T1 - Complement activation by commercial allergen extracts of cereal grains.
JO - Clinical Allergy: Journal of the British Allergy Society
JF - Clinical Allergy: Journal of the British Allergy Society
Y1 - 1980/07//
VL - 10
IS - 4
M3 - Article
SP - 395
EP - 404
PB - Wiley-Blackwell
SN - 00099090
N1 - Accession Number: 16471629; Olenchock, S. A. 1,2 Mull, J. C. 1,2 Major, P. C. 1,2; Affiliation: 1: Immunology Section, Division of Respriratory Disease Studies, NIOSH, Morgantown, West Virginia, U.S.A. 2: National Institute for Occupational Safety and Health; Source Info: Jul1980, Vol. 10 Issue 4, p395; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blanchard, Evelyn Lance
AU - Barsh, Russel Lawrence
T1 - What is best for tribal children? a response to Fischler.
JO - Social Work
JF - Social Work
Y1 - 1980/09//
VL - 25
IS - 5
M3 - Article
SP - 350
EP - 357
PB - Oxford University Press / USA
SN - 00378046
AB - The passage of the Indian Child Welfare Act has caused great concern and misunderstanding among social workers. The authors discuss American Indian child-rearing practices and their implications for social work and clarify some of the most frequently misunderstood provision of the act. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE American children -- Legal status, laws, etc.
KW - SOCIAL workers
KW - CHILD rearing
KW - SOCIAL work with children
KW - CHILD welfare
KW - UNITED States
N1 - Accession Number: 5268881; Blanchard, Evelyn Lance 1,2 Barsh, Russel Lawrence 3; Affiliation: 1: Secretary, Association of American Indian and Alaska Native Social Workers. 2: Community Development Specialist, Indian Health Service, Portland, Oregon. 3: Associate Professor of Business, Government, and Society, Graduate School of Business Administration, University of Washington, Seattle.; Source Info: Sep80, Vol. 25 Issue 5, p350; Subject Term: NATIVE American children -- Legal status, laws, etc.; Subject Term: SOCIAL workers; Subject Term: CHILD rearing; Subject Term: SOCIAL work with children; Subject Term: CHILD welfare; Subject Term: UNITED States; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenstein, David I.
AU - Cogan, Gerald L.
AU - Joseph, Lireka P.
T1 - Network capitation practices: a new concept.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1980/10//
VL - 8
IS - 7
M3 - Article
SP - 351
EP - 354
SN - 03015661
AB - The percentage of consumers in the U. S. covered by dental insurance has increased dramatically over the last 10 years. As dental insurance grows, it is becoming increasingly important to examine the context of dental care payment systems. At present, almost all insurance programs are geared toward the fee-for-service system, which reimburses dentists a fixed sum for each type of procedure. The exceptions to lee-for-service dental insurance plans are few. A capitation program for dental care, which reimburses dentists a fixed amount per enrolled patient regardless of services rendered, offers many advantages for both consumers and providers and should be available as an option. Network capitation represents a new approach to the payment of dental care. A network capitation program is being developed in the United States and will use an approach involving two contracts, one which will be used with an insurance company, and the second with a network of private practitioners. The insurance company will supply dental practices with dental patients and funds on a capitation basis. Patients will be given the choice of fee-for-service or capitation. Network capitation allows fee-for-service solo or group practitioners to incorporate capitation patients into their practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL insurance
KW - DENTAL care
KW - CONSUMERS
KW - CAPITATION fees (Medical care)
KW - DENTISTRY
KW - UNITED States
KW - dental insurance
KW - health economy.
N1 - Accession Number: 12096108; Rosenstein, David I. 1 Cogan, Gerald L. 2 Joseph, Lireka P. 3; Affiliation: 1: Department of Public Health Dentistry, School of Dentistry, University of Oregon Health Sciences Center, Washington, D. C., U. S. A.. 2: Dental Registry Inc., Portland, Oregon, Washington, D. C. U. S. A.. 3: Food and Drug Administration Public Health Service, Department of Health and Human Services, Washington, D. C., U. S. A..; Source Info: Oct1980, Vol. 8 Issue 7, p351; Subject Term: DENTAL insurance; Subject Term: DENTAL care; Subject Term: CONSUMERS; Subject Term: CAPITATION fees (Medical care); Subject Term: DENTISTRY; Subject Term: UNITED States; Author-Supplied Keyword: dental insurance; Author-Supplied Keyword: health economy.; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1600-0528.ep12096108
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maibach, H. I.
AU - Akerson, J. M.
AU - Marzulli, F. N.
AU - Wenninger, J.
AU - Greif, M.
AU - Hjorth, N.
AU - Andersen, K. E.
AU - Wilkinson, D. S.
T1 - Test concentrations and vehicles for dermatological testing of cosmetic ingredients.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1980/10//
VL - 6
IS - 6
M3 - Article
SP - 369
EP - 404
SN - 01051873
AB - In the past, identification of the ingredients responsible for cosmetic allergic reactions was hampered by the difficulty of obtaining ingredient information for individual marketed cosmetic products, as of December 1980. Although some cosmetic companies provided ingredient information for their products, most required that an individual letter be written for each product. Since 1978, the U.S. regulations have required that all ingredients, except components of flavours and fragrances be declared on cosmetic product labels.
KW - COSMETICS
KW - ALLERGY
KW - COSMETICS industry -- Law & legislation
KW - TRADE regulation
KW - LABELING
KW - UNITED States
N1 - Accession Number: 17276622; Maibach, H. I. 1 Akerson, J. M. 2 Marzulli, F. N. 2 Wenninger, J. 2 Greif, M. 2 Hjorth, N. 3 Andersen, K. E. 3 Wilkinson, D. S. 4; Affiliation: 1: University of California Hospital, San Francisco, California 94143 U.S.A. 2: Food and Drug Administration, Division of Cosmetics Technology, Washington D. C. 20204 U.S.A. 3: Gentofte Hospital, 2900 Hellerup, Denmark 4: Wycombe General Hospital, High Wycombe, Bucks., England; Source Info: 1980, Vol. 6 Issue 6, p369; Subject Term: COSMETICS; Subject Term: ALLERGY; Subject Term: COSMETICS industry -- Law & legislation; Subject Term: TRADE regulation; Subject Term: LABELING; Subject Term: UNITED States; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 36p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Manders, David
AU - Harris, Patricia Roberts
T1 - Correspondence.
JO - New Republic
JF - New Republic
Y1 - 1980/10/18/
VL - 183
IS - 16
M3 - Letter
SP - 3
EP - 40
SN - 00286583
AB - Presents letters to the editor referencing articles and topics discussed in previous issues. Criticism of the review by Herbert Gintis of the book "Inequality in an Age of Decline" in the September 6 issue; Arguments given by Patricia Roberts Harris, U.S. Secretary of Health and Human Services to defend herself against statements about her published in the September 27 issue; Comments on the nomination of Ronald Reagan for the presidential elections.
KW - LETTERS to the editor
KW - PRESIDENTIAL candidates
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
KW - GINTIS, Herbert
KW - HARRIS, Patricia, 1924-1985
KW - REAGAN, Ronald, 1911-2004
KW - INEQUALITY in an Age of Decline (Book)
N1 - Accession Number: 11106403; Manders, David Harris, Patricia Roberts 1; Affiliation: 1: Secretary of Health and Human Services Washington, DC; Source Info: 10/18/80, Vol. 183 Issue 16, p3; Subject Term: LETTERS to the editor; Subject Term: PRESIDENTIAL candidates; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services; Reviews & Products: INEQUALITY in an Age of Decline (Book); NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: GINTIS, Herbert; People: HARRIS, Patricia, 1924-1985; People: REAGAN, Ronald, 1911-2004; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schmitt, Neal
AU - Colligan, Michael J.
AU - Fitzgerald, Michael
T1 - Unexplained physical symptoms in eight organizations: Individual and organizational analysis.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1980/12//
VL - 53
IS - 4
M3 - Article
SP - 305
EP - 317
PB - Wiley-Blackwell
SN - 03058107
AB - Data collected from 826 people in eight American organizations concerning mass reports of symptoms and various possible indicants of stress were subjected to correlational and regression analyses. In addition, using the argument that illness was actually an organizational phenomenon, company means of 41 predictor variables were correlated with company means on the symptoms variable. The three sets of analyses indicate that reported symptoms are related to work pressure, employee income, family disharmony and dissatisfaction with company personnel practices. Limitations of the data collection effort are noted and recommendations for future investigations are made. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - STRESS (Psychology)
KW - INDUSTRIAL psychology
KW - WORK -- Psychological aspects
KW - CORRELATION (Statistics)
KW - REGRESSION analysis
KW - INCOME
N1 - Accession Number: 4618974; Schmitt, Neal 1 Colligan, Michael J. 2 Fitzgerald, Michael 1; Affiliation: 1: Michigan State University 2: National Institute for Occupational Safety and Health; Source Info: Dec80, Vol. 53 Issue 4, p305; Subject Term: JOB stress; Subject Term: STRESS (Psychology); Subject Term: INDUSTRIAL psychology; Subject Term: WORK -- Psychological aspects; Subject Term: CORRELATION (Statistics); Subject Term: REGRESSION analysis; Subject Term: INCOME; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kingon, Robert J.
AU - Wiesner, Paul J.
T1 - Premarital Syphilis Screening: Weighing the Benefits.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/02//
VL - 71
IS - 2
M3 - Article
SP - 160
EP - 162
PB - American Public Health Association
SN - 00900036
AB - This article discusses issues regarding the mandatory premarital syphilis screening in the U.S. State health authorities are deliberating on whether to retain, repeal or modify requirements for the premarital law. The main argument of most proponents of repeal deals with the lack of cost effectiveness of premarital screening and suggests the consideration of more effective syphilis control activities. However, in making an informed decision, the state policymaker should consider the benefits of a premarital serologic tests which include the detection and prevention of early syphilis and detection of latent disease and prevention of complications.
KW - PREMARITAL examinations
KW - SYPHILIS -- Diagnosis
KW - MEDICAL screening
KW - COST analysis
KW - DIAGNOSTIC services
KW - UNITED States
N1 - Accession Number: 4948005; Kingon, Robert J. 1 Wiesner, Paul J. 2; Affiliation: 1: Chief, Program Development Section, VD Control Division, BSS, CDC, Atlanta 2: Director, Venereal Disease Control Division, Bureau of State Services, Center for Disease Control, U.S. Department of Health & Human Services, Public Health Service, Atlanta, GA 30333; Source Info: Feb1981, Vol. 71 Issue 2, p160; Subject Term: PREMARITAL examinations; Subject Term: SYPHILIS -- Diagnosis; Subject Term: MEDICAL screening; Subject Term: COST analysis; Subject Term: DIAGNOSTIC services; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraemer, Kenneth H.
AU - Waters, Haywood L.
AU - Cohen, Lawrence F.
AU - Popescu, Nicolae C.
AU - Amsbaugh, Suzanne C.
AU - DiPaolo, Joseph A.
AU - Glaubiger, Daniel
AU - Ellingson, Owen L.
AU - Tarone, Robert E.
T1 - Effects of 8-Methoxypsoralen and Ultraviolet Radiation on Human Lymphoid Cells in Vitro .
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/02//
VL - 76
IS - 2
M3 - Article
SP - 80
EP - 87
SN - 0022202X
AB - Oral 8-methoxypsoralen (8-MOP) plus high-intensity long-wavelength ultraviolet radiation (UV-A) is used clinically to induce remissions of psoriasis and mycosis fungoides, Leukocytes in 8-MOP containing blood receive UV-A exposure when circulating through the dermis during therapy. The present study utilizes an in vitro assay system to permit quantitation and correlation of multiple biological and physical alterations in human lymphoid cells induced by 8-MOP plus UV-A treatment. Additive inhibition of lymphoid cell DNA synthesis by 8-MOP (0.01 to 1 μg/ml) plus UV-A (1,000 to 29,000 J/m²) was accompanied by a synergistic potentiation of cell killing in the therapeutic exposure range. Reduction in tritiated thymidine (³HTdR) incorporation to 65-70% of control value was associated with normal survival; while ³HTdR incorporation of less than 50% of control induced by any 8-MOP plus UV-A combination tested was associated with less than 10% survival, 8-MOP-DNA-cross-links were detected by the alkaline elution assay only when ³HTdR incorporation was reduced to less than 50% of control. The relative number of crosslinks increased proportionately with further 8-MOP plus UV-A-induced reduction in ³HTdR incorporation. 8-MOP plus UV-A induced at most approximately a 2-fold increase in sister chromatid exchanges (SCE) per chromosome in lymphocytes or lymphoblastoid cells, Increasing 8-MOP plus UV-A exposure resulted in marked toxicity with few cells progressing to second division metaphases and no further increase in SCE's per chromosome, Addition of 13-cis retinoic acid (1μg/ml) to the lymphoblastoid cells prior to 8-MOP plus UV-A treatment did not significantly alter the ³HTdR incorporation or cell survival. These studies dermonstrate that in vitro exposure of human lymphoid cells to therapeutic levels of 8-MOP and UV-A may decrease cellular DNA synthesis, produce DNA 8-MOP interstrand cross-links, reduce cell viability and induce small increases in sister chromosome exchanges. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOID tissue
KW - ULTRAVIOLET radiation
KW - LEUCOCYTES
KW - DNA
KW - MYCOSIS fungoides
KW - LYMPHOPROLIFERATIVE disorders
N1 - Accession Number: 12525352; Kraemer, Kenneth H. 1 Waters, Haywood L. 1 Cohen, Lawrence F. 2 Popescu, Nicolae C. 3 Amsbaugh, Suzanne C. 3 DiPaolo, Joseph A. 3 Glaubiger, Daniel 2 Ellingson, Owen L. 4 Tarone, Robert E. 5; Affiliation: 1: Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland. 2: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. 3: Laboratory of Biology, National Cancer Institute, Bethesda, Maryland. 4: Electrooptics Branch, Division of Electronic Products, Bureau of Radiologic Health, Food and Drug Administration, Rockville, Maryland, U.S.A. 5: Biometry Branch, National Cancer Institute, Bethesda, Maryland.; Source Info: Feb81, Vol. 76 Issue 2, p80; Subject Term: LYMPHOID tissue; Subject Term: ULTRAVIOLET radiation; Subject Term: LEUCOCYTES; Subject Term: DNA; Subject Term: MYCOSIS fungoides; Subject Term: LYMPHOPROLIFERATIVE disorders; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525352
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bronaugh, Robert L.
AU - Congdon, Elaine R.
AU - Scheuplein, Robert J.
T1 - The Effect of Cosmetic Vehicles on the Penetration of N -Nitrosodiethanolamine Through Excised Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/02//
VL - 76
IS - 2
M3 - Article
SP - 94
EP - 96
SN - 0022202X
AB - Cosmetic products are frequently applied to the skin by a large number of people, but some contain compounds that are potentially toxic, if absorption through the skin is sufficient. The percutaneous absorption of N-nitrosodiethanolamine (NDELA), an impurity in many cosmetic products, has been evaluated in diffusion cells using excised human skin. The nitrosamine was applied to the skin in vehicles with different solubility properties. The permeability constants for water (5.5 × 10-6 cm hr-1) and propylene glycol (3.2 × 10-6 cm hr-1) were small and similar. In isopropyl myristate, the permeability constant increased approximately 250-fold to 1.1 × 10-3 cm hr-1. The NDELA membrane:vehicle partition coefficients were determined using trypsin-treated stratum corneum as the membrane. These coefficients were 1.8 and 1.0, respectively, for water and propylene glycol and 230 for isopropyl myristate. The permeability of NDELA through skin is apparently increased greatly when applied from sufficiently lipoidal formulations; this is primarily due to the favorable partition coefficients for NDELA from such formulations. The amount of NDELA penetrating the skin from 3 types of cosmetic products was calculated based on their different conditions of use. Products applied over large areas of the body that remain on the skin for long periods of time (i.e., sun tanning lotion) will result in the greatest absorption of NDELA if all other factors are equal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COSMETICS
KW - SKIN care
KW - PERMEABILITY
KW - NITROSOAMINES
KW - CELLS
KW - ABSORPTION
N1 - Accession Number: 12525384; Bronaugh, Robert L. 1 Congdon, Elaine R. 1 Scheuplein, Robert J. 1; Affiliation: 1: Division of Toxicology, Food and Drug Administration, Washington, D. C., USA.; Source Info: Feb81, Vol. 76 Issue 2, p94; Subject Term: COSMETICS; Subject Term: SKIN care; Subject Term: PERMEABILITY; Subject Term: NITROSOAMINES; Subject Term: CELLS; Subject Term: ABSORPTION; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12525384
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pearson, D. J.
AU - Green, F. H. Y.
AU - Mentnech, Sharon M.
T1 - Soluble and particulate activators of complement and granulomatous pulmonary reactions.
JO - Clinical Allergy: Journal of the British Allergy Society
JF - Clinical Allergy: Journal of the British Allergy Society
Y1 - 1981/03//
VL - 11
IS - 2
M3 - Article
SP - 111
EP - 119
PB - Wiley-Blackwell
SN - 00099090
N1 - Accession Number: 16222628; Pearson, D. J. 1,2 Green, F. H. Y. 2 Mentnech, Sharon M. 2; Affiliation: 1: Department of Medicine, University Hospital of South Manchester, Manchester M20, 8LR 2: Immunology and Pathology Sections, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. U.S.A.; Source Info: Mar1981, Vol. 11 Issue 2, p111; Number of Pages: 9p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Temkin-Greener, Helena
AU - Kunitz, Stephen J.
AU - Broudy, David
AU - Haffner, Marlene
T1 - Surgical Fertility Regulation among Women on the Navajo Indian Reservation, 1972-1978.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/04//
VL - 71
IS - 4
M3 - Article
SP - 403
EP - 407
PB - American Public Health Association
SN - 00900036
AB - Abstract: Changes in the rates of induced abortions, bilateral tubal ligations, and hysterectomies on the Navajo Indian Reservation have been examined for the years 1972-1978. While the incidence of abortions and tubal sterilizations is still considerably lower among Navajo women than among the total United States population of women, it has risen, especially among those in the prime of the reproductive cycle, i.e., ages 20-34. The rate of hysterectomy has not changed substantially. Regression analyses performed on the data indicate that the utilization of surgery for fertility regulation in women on the Navajo Reservation, unlike other surgical procedures, is not affected by access to hospitals which provide surgery. Rather measures of involvement in the wage work economy are of primary importance. Those areas of the Reservation having the highest levels of such involvement exhibit the highest rates of such surgery. (Am J Public Health 1981: 71:403-407.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GYNECOLOGIC surgery
KW - NAVAJO (North American people)
KW - ABORTION
KW - HYSTERECTOMY
KW - STERILIZATION of women
KW - NAVAJO Indian Reservation
N1 - Accession Number: 4954759; Temkin-Greener, Helena 1 Kunitz, Stephen J. 1 Broudy, David 2 Haffner, Marlene 2; Affiliation: 1: Department of Preventive, Family, and Rehabilitation Medicine, Box 644, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642 2: Navajo Area Indian Health Service, Window Rock, AZ; Source Info: Apr1981, Vol. 71 Issue 4, p403; Subject Term: GYNECOLOGIC surgery; Subject Term: NAVAJO (North American people); Subject Term: ABORTION; Subject Term: HYSTERECTOMY; Subject Term: STERILIZATION of women; Subject Term: NAVAJO Indian Reservation; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaminski, Rose
AU - Brockert, John
AU - Sestito, John
AU - Frazier, Todd
T1 - Occupational Information on Death Certificates: A Survey of State Practices.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/05//
VL - 71
IS - 5
M3 - Article
SP - 525
EP - 526
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national survey was conducted in 1979 to determine the extent to which state and local vital registration offices coded and stored occupational information reported on death certificates. This survey found that 11 states routinely code occupation, seven routinely code, industry and six have coded occupation and/or industry on a limited basis. Stale and federal cooperation is needed to facilitate increased of mortality data for environmental and occupational health research. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL surveys
KW - PERSONAL information management
KW - OCCUPATIONS
KW - DEATH certificates
KW - INDUSTRIAL hygiene
N1 - Accession Number: 4949353; Kaminski, Rose 1 Brockert, John 2,3 Sestito, John 1,2 Frazier, Todd 1,2; Affiliation: 1: Robert Taft Laboratories, NIOSH, 4676 Columbia Park-way, Cincinnati, OH 45226 2: National Institute for Occupational Safety and Health, American Association for Vital Records and Public Health Statistics 3: Utah State Health Department; Source Info: May81, Vol. 71 Issue 5, p525; Subject Term: INDUSTRIAL surveys; Subject Term: PERSONAL information management; Subject Term: OCCUPATIONS; Subject Term: DEATH certificates; Subject Term: INDUSTRIAL hygiene; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andersen, F. Alan
AU - Landry, Robert J.
T1 - Optical Radiation Measurements and Instrumentation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1981/07//
VL - 77
IS - 1
M3 - Article
SP - 8
EP - 12
SN - 0022202X
AB - Accurate measurement of optical radiation is required when sources of optical radiation are used in biological research. Such measurement of broad-band noncoherent optical radiations usually must be performed by a highly trained specialist using sophisticated, complex, and expensive instruments. Presentation of the results of such measurement requires correct use of quantities and units with which many biological researchers are unfamiliar. The measurement process, quantities, units, measurement systems and instruments, and uncertainties associated with optical radiation measurements are reviewed in this paper. A conventional technique for evaluating the potential hazards associated with broad-band sources of optical radiation and a spectroradiometer developed to measure spectral quantities is described. A new prototype ultraviolet radiation hazard monitor which has recently been developed is also presented. This new instrument utilizes a spectrograph and a spectral weighting mechanical mask and provides a direct reading of the effective irradiance for wavelengths less than 315 nm. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPTICAL radiometry
KW - BIOLOGICAL research
KW - SPECTRORADIOMETER
KW - RADIATION measurements
KW - RADIOMETERS
KW - RADIOLOGY
N1 - Accession Number: 12479190; Andersen, F. Alan 1 Landry, Robert J. 1; Affiliation: 1: Bureau of Radiological Health, Food and Drug Administration, Rockville, Maryland, U.S.A.; Source Info: Jul81, Vol. 77 Issue 1, p8; Subject Term: OPTICAL radiometry; Subject Term: BIOLOGICAL research; Subject Term: SPECTRORADIOMETER; Subject Term: RADIATION measurements; Subject Term: RADIOMETERS; Subject Term: RADIOLOGY; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12479190
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Landrigan, Philip J.
AU - Gross, Richard L.
T1 - Chemical Wastes--Illegal Hazards and Legal Remedies.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1981/09//
VL - 71
IS - 9
M3 - Editorial
SP - 985
EP - 987
PB - American Public Health Association
SN - 00900036
AB - The author reflects on the health hazards caused by toxic wastes disposed of by chemical manufacturers. Some of these substances are carcinogens, neurotoxins and compounds capable of causing reproductive impairment. He suggested remedies of reducing occupational exposures to chemical wastes and controlling contamination of ground and surface waters.
KW - HAZARDOUS wastes
KW - CHEMICAL industry
KW - PUBLIC health
KW - CARCINOGENS
N1 - Accession Number: 4949601; Landrigan, Philip J. 1 Gross, Richard L. 2; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies 2: Division of Criteria Documents and Standards Development National Institute for Occupational Safety and Health; Source Info: Sep81, Vol. 71 Issue 9, p985; Subject Term: HAZARDOUS wastes; Subject Term: CHEMICAL industry; Subject Term: PUBLIC health; Subject Term: CARCINOGENS; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Christensen-Szalanski, Jay J. J.
AU - Diehr, Paula H.
AU - Wood, Robert W.
AU - Tompkins, Richard K.
T1 - Phased Trial of a Proven Algorithm At a New Primary Care Clinic.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/01//
VL - 72
IS - 1
M3 - Article
SP - 16
PB - American Public Health Association
SN - 00900036
AB - A previous study showed that a clinical algorithm for respiratory illnesses consisting of a checklist, a set of instructions (logic), and computer audit/feedback, could reduce costs significantly while maintaining a high quality of care. The results of this study show that the algorithm system, developed and validated at one primary care clinic can be successfully imported to another primary care clinic. In the present study, the algorithm system significantly improved the completeness of the medical records reduced the use of medical tests by 20 per cent-75 per cent and reduced non-provider costs by 36 per cent per patient visit. This study also shows that all three components of the algorithm system appear to he necessary to achieve these improvements and maintain a high quality of medical care. These results suggest that a wider use of the algorithm system for minor acute medical problems is both feasible and useful in providing high-quality cost-effective care that is audilable. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL protocols
KW - RESEARCH
KW - MEDICAL informatics
KW - COST control
KW - PRIMARY care (Medicine)
KW - MEDICAL records
KW - MEDICAL care
KW - COMPUTERIZED auditing
KW - PATIENTS
KW - CARING
KW - ALGORITHMS
KW - COST effectiveness
N1 - Accession Number: 4949267; Christensen-Szalanski, Jay J. J. 1 Diehr, Paula H. 2 Wood, Robert W. 3 Tompkins, Richard K. 4; Affiliation: 1: Department of Health Services Research, United States Public Health Service Hospital, Seattle, Washington, University of Washington, Seattle. 2: Department of Health Services, School of Public Health and Community Medicine, University of Washington, Seattle 3: Department of Biostatistics, School of Public Health and Community Medicine, , University of Washington, Seattle. 4: Department of Medicine, School of Medicine, University of Washington, Seattle.; Source Info: Jan1982, Vol. 72 Issue 1, p16; Subject Term: MEDICAL protocols; Subject Term: RESEARCH; Subject Term: MEDICAL informatics; Subject Term: COST control; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL records; Subject Term: MEDICAL care; Subject Term: COMPUTERIZED auditing; Subject Term: PATIENTS; Subject Term: CARING; Subject Term: ALGORITHMS; Subject Term: COST effectiveness; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Landrigan, Philip J.
T1 - Recent advances in assessment of workplace exposure—epidemiologic linkage of medical and environmental data.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 499
EP - 513
SN - 03601226
AB - The toxicity to man of environmental agents is most accurately assessed when quantitative data are available on both exposure (dose) and response. Worker populations are of unique importance in the study of toxic effects because they are relatively well defined, easily traced, and more heavily exposed to toxic chemical and physical agents than are members of the general community. The union of epidemiology, industrial hygiene, and occupational medicine has made possible the sophisticated study of acute, subacute, and chronic dose‐response relationships in worker populations. This report describes the application of epidemiology to evaluations of workers exposed to methyl alcohol vapor (acute toxicity), ozone (subacute), and lead and ionizing radiation (chronic). The derivation of accurate dose‐response data provides a rational basis for the establishment of exposure standards. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490499; Landrigan, Philip J. 1; Affiliation: 1: Director. Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health; Source Info: Jan1982, Vol. 17 Issue 4, p499; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/10934528209375051
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beland, Frederick A.
AU - Kadlubar, F. Frank
AU - Swenson, D. Harold
T1 - Mechanistic approaches to biochemical toxicology.
JO - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
JF - Journal of Environmental Science & Health, Part A: Environmental Science & Engineering
Y1 - 1982/01/04/
VL - 17
IS - 4
M3 - Article
SP - 581
EP - 588
SN - 03601226
AB - Mechanistic approaches to the study of toxicology should allow for better assessment of human health risks. Five general research areas are outlined. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Environmental Science & Health, Part A: Environmental Science & Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75490508; Beland, Frederick A. 1 Kadlubar, F. Frank 1 Swenson, D. Harold 1,2; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas, 72079 2: Genetic Toxicology Unit, The Upjohn Company, Kalamazoo, Michigan; Source Info: Jan1982, Vol. 17 Issue 4, p581; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10934528209375060
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Van Houte, A. J.
AU - Janssen, A.
AU - Lizzio, Elaine F.
AU - Willers, J. M. N.
AU - Merchant, B.
T1 - Characterization of immunogenic properties of haptenated liposomal model membranes in mice VII. SYNERGISTIC RESPONSES TO HAPTENATED LIPOSOMES AND HAPTENATED THYMUS-DEPENDENT ANTIGENS IN CBA/N MICE.
JO - Immunology
JF - Immunology
Y1 - 1982/04//4/1/82
VL - 45
IS - 4
M3 - Article
SP - 613
EP - 620
PB - Wiley-Blackwell
SN - 00192805
AB - CBA/N mice have an X-linked S-cell defect which prevents them from responding to non- mitogenic thymus-independent (T1-2) antigens such as haptenated Ficoll. The CBA/N mice do, however, respond to another group of thymus-independent (TI-2) antigens among which are haptenated liposomes. The F1 male progeny of CBA/N female mice express the same characteristics. Hapten-specific plaque-forming cell (PFC) responses to haptenated proteins (thymus-dependent, TD, antigens) by CSA/N mice and CBA/N × C3H/HeN F1 male mice can be blocked by concomitant exposure to TI-2 antigens bearing the same hapten. Simultaneous exposure to haptenated liposomes (TI- I antigen) and TD antigens, however, results in a synergistic response to the hapten if the antigens share common epitopes. The tripeptide-enlarged hapten dinitrophenyl-β-alanylgly- cylglycine (J), conjugated to phosphatidyl-ethanol- amine (PE) and incorporated into liposomal model membranes, was used throughout the experiments. In F1 male mice the moderate responses to TD antigens could be restored to values equivalent to those seen in F1 female mice. This adjuvant effect of haptenated liposomes is hapten-specific, time-dependent, and restricted to certain structural forms of the liposomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - ANTIGENS
KW - THYMUS
KW - FICOLL
KW - LIPOSOMES
KW - DINITROBENZENES
N1 - Accession Number: 14004385; Snippe, H. 1 Van Houte, A. J. 1 Janssen, A. 1 Lizzio, Elaine F. 2 Willers, J. M. N. 1 Merchant, B. 2; Affiliation: 1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands. 2: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: 4/1/82, Vol. 45 Issue 4, p613; Subject Term: MICE; Subject Term: ANTIGENS; Subject Term: THYMUS; Subject Term: FICOLL; Subject Term: LIPOSOMES; Subject Term: DINITROBENZENES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bienia, Richard A.
AU - VanderDecker, John D.
AU - Bienia, Baroline H.
T1 - Cuban Refugee Health Care: Response of the American Health Care System to the Unexpected Arrival of 125,000 Immigrants.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/06//
VL - 72
IS - 6
M3 - Article
SP - 594
EP - 596
PB - American Public Health Association
SN - 00900036
AB - During the spring of 1980, over 120,000 Cuban refugees emigrated to the United States. Their rapid, unexpected arrival overwhelmed existing health care facilities in south Florida. Government-operated screening centers capable of handling large patient loads were established. Health screening involved a brief history and physical examination and a search for active tuberculosis and venereal disease. Thousands of refugees were processed rapidly and released to waiting relatives and sponsors. Many others, who for social or psychological reasons could not be released, were transferred to holding centers in various parts of the country. US Public Health Service physicians were faced with difficulties whose basic cause could be traced to the boredom of camp life and stresses due to uncertainty regarding the future. Acting out and compliance problems with medical aftermaths were common. About 3,000 refugees remain in custody today. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REFUGEES
KW - IMMIGRANTS
KW - MEDICAL care
KW - HEALTH facilities
KW - PHYSICIANS
KW - LUNG diseases
KW - SEXUALLY transmitted diseases
KW - TUBERCULOSIS
KW - MENTAL fatigue
KW - HUMAN RESOURCES AND SOCIETY
N1 - Accession Number: 4949826; Bienia, Richard A. 1 VanderDecker, John D. 2,3 Bienia, Baroline H. 4; Affiliation: 1: Director, Primary Care Medicine Residency, Department of Medicine, Eastern Virginia Medical School, 600 Gresham Drive, Norfolk, VA 23501. 2: Chief of Medicine, Public Health Service Hospital 3: Associate Professor, Department of Medicine 4: Director, Health Education and Training, PHS Hospital; Source Info: Jun82, Vol. 72 Issue 6, p594; Subject Term: REFUGEES; Subject Term: IMMIGRANTS; Subject Term: MEDICAL care; Subject Term: HEALTH facilities; Subject Term: PHYSICIANS; Subject Term: LUNG diseases; Subject Term: SEXUALLY transmitted diseases; Subject Term: TUBERCULOSIS; Subject Term: MENTAL fatigue; Author-Supplied Keyword: HUMAN RESOURCES AND SOCIETY; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ribi, E.
AU - Granger, D. L.
AU - Milner, K. C.
AU - Yamamoto, K.
AU - Strain, S. M.
AU - Parker, R.
AU - Smith, R. W.
AU - Brehmer, W.
AU - Azuma, I.
T1 - Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.
JO - Immunology
JF - Immunology
Y1 - 1982/06//
VL - 46
IS - 2
M3 - Article
SP - 297
EP - 305
PB - Wiley-Blackwell
SN - 00192805
AB - Factors contributing to protection against experimental tuberculosis have been studied with refined and well characterized fractions from mycobacteria and with certain unrelated antigens. Mice were vaccinated intravenously with various combinations of materials presented on minute oil droplets in saline emulsion and were later challenged by aerosol. The minimal composition of an effective vaccine was P3 (a trehalose mycolate similar to cord factor) plus an antigen, which could be tuberculoprotein, or a low-molecular-weight tuberculin-active peptide, or unrelated antigen such as bovine serum albumin or bacterial endotoxin. Development of a hypersensitivity granuloma in the lungs appeared to be essential to protection in this laboratory model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIA
KW - TUBERCULOSIS
KW - ANTIGENS
KW - TUBERCULIN
KW - GRANULOMA
KW - IMMUNOLOGY
N1 - Accession Number: 13991040; Ribi, E. 1 Granger, D. L. 1 Milner, K. C. 1 Yamamoto, K. 2 Strain, S. M. 3 Parker, R. 3 Smith, R. W. 1 Brehmer, W. 4 Azuma, I. 2; Affiliation: 1: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana, U.S.A 2: Institute of Immunological Science, Hokkaido University, Sapporo, Japan 3: Hamilton Biochemical Research Laboratory 4: Robert Koch Institute, Federal Health Office, 1000 Berlin 65, Germany; Source Info: Jun82, Vol. 46 Issue 2, p297; Subject Term: MYCOBACTERIA; Subject Term: TUBERCULOSIS; Subject Term: ANTIGENS; Subject Term: TUBERCULIN; Subject Term: GRANULOMA; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Littleton Jr., Preston A.
T1 - Toward a Theory of the Dental Care Market: A Critique.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/07//
VL - 72
IS - 7
M3 - Article
SP - 676
EP - 678
PB - American Public Health Association
SN - 00900036
AB - The primary contribution of Lipscomb and Douglass's1 interesting paper is to expand economists' traditionally narrow view of dentistry and the other health professions by identifying and attempting to incorporate important characteristics of the professions into a theoretical account of the dental care market. Four issues that the authors either identify or will encounter in the empirical testing of their model are addressed in this discussion. These are: I) the costs and benefits associated with both governmental regulation of the profession and self-imposed codes of professional conduct; 2) the dynamics of the ‘recent graduate-established dentist’ dichotomy; 3) the organizational hierarchy of the profession and its relative importance in controlling the dental care market; and 4) data limitations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Research
KW - DENTISTRY
KW - DENTAL care
KW - MEDICAL personnel
KW - PROFESSIONALISM
KW - MEDICINE
KW - HEALTH maintenance organization medical offices
KW - ORGANIZATIONAL structure
KW - CORE competencies
N1 - Accession Number: 4950397; Littleton Jr., Preston A. 1; Affiliation: 1: Dental Consultant, Office of the Chief Dental Officer, Office of the Assistant Secretary of Health, US Public Health Service, DHHS, Washington, DC; Source Info: Jul1982, Vol. 72 Issue 7, p676; Subject Term: MEDICAL care -- Research; Subject Term: DENTISTRY; Subject Term: DENTAL care; Subject Term: MEDICAL personnel; Subject Term: PROFESSIONALISM; Subject Term: MEDICINE; Subject Term: HEALTH maintenance organization medical offices; Subject Term: ORGANIZATIONAL structure; Subject Term: CORE competencies; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Attico, N. Burton
AU - Dales, Loring
AU - Chin, James
AU - Mann, Jonathan M.
AU - Montes, Jean
AU - Kenney, Michael L.
AU - MacLeod, Gordon K.
AU - Christopher Maxwell
AU - Rosenblum, Marcus M.
AU - Cotler, Miriam Piven
AU - Mumford, Emily
AU - Woods, Nancy F.
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/08//
VL - 72
IS - 8
M3 - Letter
SP - 855
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Public Health Implications of Rubella Antibody Levels in California," by L.G. Dales and J. Chin in the 1982 issue.
KW - LETTERS to the editor
KW - RUBELLA -- Vaccination
N1 - Accession Number: 4949517; Attico, N. Burton 1 Dales, Loring 2 Chin, James 2 Mann, Jonathan M. 3 Montes, Jean 3 Kenney, Michael L. MacLeod, Gordon K. 4 Christopher Maxwell 5 Rosenblum, Marcus M. Cotler, Miriam Piven 6 Mumford, Emily 7 Woods, Nancy F. 8; Affiliation: 1: Area Maternal Health Consultant, DHHS/PHS/HSA, Phoenix Area Indian Health Service, Phoenix, AZ 85016-5981. 2: Infectious Disease Section, California State Department of Health Services, 2151 Berkeley Way, Berkeley, CA 94704. 3: Assistant Director, Health Promotion-Disease Prevention, Health Services Division, State of New Mexico, Santa Fe, NM 87503. 4: Professor and Chairman, Department of Health Services Administration, University of Pittsburg, Graduate School of Public Health, Pittsburgh, PA 15261. 5: Director, Respiratory Therapy, Commnunity Genera! Osteopathic Hospital, Harrisburg, PA 17105. 6: Doctoral student, Health Services, UCLA Instructor, CSUN. 7: Professor of Psychiatry and Preventive Medicine, University of Colorado, HeaIth Sciences Center, Denver, CO 80262. 8: Associate Professor, Dept. of Psychological Nursing, School of Nursing, University of Washington, Seattle, WA 98195.; Source Info: Aug1982, Vol. 72 Issue 8, p855; Subject Term: LETTERS to the editor; Subject Term: RUBELLA -- Vaccination; Number of Pages: 5p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsokos, G. C.
AU - Rook, A. H.
AU - Djeu, Julie Y.
AU - Balow, J. E.
T1 - Natural killer cells and interferon responses in patients with systemic lupus erythematosus.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/08//
VL - 49
IS - 2
M3 - Article
SP - 239
EP - 245
PB - Wiley-Blackwell
SN - 00099104
AB - Natural killer (NK) cell activity was studied in 23 patients with systemic lupus erythematosus (SLE), The overall NK activity was lower in patients with SLE than in normal female individuals. Patients with clinically active SLE disease had slightly lower NK activity than the patients with inactive disease. Other clinical parameters as well as treatment status did not correlate with NK activity. Interferon (IFN) enhanced the NK activity of normal individuals and of 11 SLE patients, while it did not enhance in the remaining 12 patients. The patients whose NK activity was enhanced by β/IFN had significantly higher initial activity than those who did not respond to β/IFN. Furthermore, peripheral mononuclear cells (MNC) from IFN responders produced γ-IFN after stimulation with concanavalin A (Con A) in titres comparable to those of normals. In contrast, peripheral MNC from β-IFN non-responders failed to produce significant titres of γ-IFN after stimulation with Con A. These results indicate that certain patients with SLE have low NK activity, which is generally paralleled by an inability to respond to exogenous β-IFN and by blunted production of γ-IFN after stimulation with Con A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - SYSTEMIC lupus erythematosus
KW - INTERFERONS
KW - COLLAGEN diseases
KW - IMMUNOCOMPETENT cells
KW - AUTOIMMUNE diseases
N1 - Accession Number: 16252893; Tsokos, G. C. 1 Rook, A. H. 1 Djeu, Julie Y. 1 Balow, J. E. 1; Affiliation: 1: Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health and Division of Virology, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, USA.; Source Info: Aug1982, Vol. 49 Issue 2, p239; Subject Term: KILLER cells; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: INTERFERONS; Subject Term: COLLAGEN diseases; Subject Term: IMMUNOCOMPETENT cells; Subject Term: AUTOIMMUNE diseases; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bullock, W. E.
AU - Watson, Susan
AU - Nelson, K. E.
AU - Schauf, Victoria
AU - Makonkawkeyoon, S.
AU - Jacobson, R. R.
T1 - Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1982/10//
VL - 50
IS - 1
M3 - Article
SP - 105
EP - 114
PB - Wiley-Blackwell
SN - 00099104
AB - The capacity of peripheral blood mononuclear (PBM) cells from patients with leprosy to generate immunoglobulin-secreting cells in response to pokeweed mitogen (PWM) was evaluated by a reverse haemolytic plaque forming cell (PFC) assay. The PFC responses of PBM cells from patients with lepromatous (Lpr) leprosy were significantly higher (P<001) than those of PBM cells from normal controls and patients with tuberculoid leprosy. Co-culture of T lymphocytes from normal donors with PBM cells from Lpr patients reduced the PFC response of these cells to the normal range. T4+-helper lymphocytes from Lpr donors did not induce supranormal responses to PWM by normal PBM cells enriched for B lymphocytes. T8+-suppressor lymphocytes from normal donors greatly reduced the response of cultures containing normal allogeneic B cells plus T4+ cells. Conversely, when T8+ cells from Lpr donors were co-cultured with normal B cells plus T4+ cells, they failed to suppress the response to PWM. En summary, these studies have demonstrated abnormally high PWM-stimulated PFC responses by B lymphocytes from patients with Lpr leprosy. This aberration, in turn, is associated with a loss of regulatory function by T8+-suppressor cells in Lpr patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response -- Regulation
KW - LYMPHOCYTES
KW - LEPROSY
KW - MYCOBACTERIAL diseases
KW - LEUCOCYTES
KW - T cells
N1 - Accession Number: 16062881; Bullock, W. E. 1,2,3,4 Watson, Susan 1,2,3,4 Nelson, K. E. 1,2,3,4 Schauf, Victoria 1,2,3,4 Makonkawkeyoon, S. 1,2,3,4 Jacobson, R. R. 1,2,3,4; Affiliation: 1: Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. 2: Departments of Preventive Medicine and Pediatrics, University of Illinois School of Medicine. Chicago, Illinois. 3: Chiang Mai University, Chiang Mai, Thailand. 4: The United States Public Health Service Hospital, Carville, Louisiana.; Source Info: Oct1982, Vol. 50 Issue 1, p105; Subject Term: IMMUNE response -- Regulation; Subject Term: LYMPHOCYTES; Subject Term: LEPROSY; Subject Term: MYCOBACTERIAL diseases; Subject Term: LEUCOCYTES; Subject Term: T cells; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaplan, Jonathan E.
AU - Feldman, Roger
AU - Campbell, Douglas S.
AU - Lookasaugh, Cindy
AU - Gary, G. William
T1 - The Frequency of a Norwalk-Like Pattern Of Illness in Outbreaks of Acute Gastroenteritis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1982/12//
VL - 72
IS - 12
M3 - Article
SP - 1329
PB - American Public Health Association
SN - 00900036
AB - Abstract: Records of 642 outbreaks of acute gastroenteritis were reviewed to determine the proportion of outbreaks that were clinically and epidemiologically consistent with Norwalk-like virus infection. Using as our criteria stool cultures negative for bacterial pathogens. mean (or median) duration of illness 12-60 hours, vomiting in is ≥ 50 per ¢ of cases, and, if known, mean (or median) incubation period of 24-48 hours, we found that 23 per ¢ of waterborne outbreaks. 4 per ¢ of foodborne outbreaks, and 67 per ¢, 60 per ¢, and 28 per ¢ of outbreaks in nursing homes, in summer camps, and on cruise ships. respectively, satisfied the criteria for Norwalk-like pattern. Of 54 outbreaks that satisfied the criteria for Norwalk-like pattern, 14 were investigated for virus etiology. Ten of these (71 per ¢) yielded serologic evidence of Norwalk-like virus infection. Norwalk-like viruses are probably an important cause of outbreaks of acute gastroenteritis, investigation for Norwalk virus antibody in outbreaks that are clinically and epidemiologically consistent with Norwalk-like virus infection ix likely to yield diagnostically useful results. (Am J Public Health 1982; 72: 1329-1332.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS
KW - VIRAL gastroenteritis
KW - VIRUS diseases
KW - PATHOGENIC microorganisms
KW - PUBLIC health
KW - NURSING care facilities
KW - HEALTH facilities
KW - OLDER people
KW - DISEASES -- Causes & theories of causation
KW - EPIDEMIOLOGY
N1 - Accession Number: 4948804; Kaplan, Jonathan E. 1 Feldman, Roger 1 Campbell, Douglas S. 1 Lookasaugh, Cindy 1 Gary, G. William 1; Affiliation: 1: Viral and Bacterial Diseases Divisions (Atlanta, GA) and the Viral Enteritis and Hepatitis Division (Phoenix, AZ), Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services; Office of Public Health, New York State Department of Health, Albany, NY and the Pinellas County Health Department, St. Petersburg, FL; Source Info: Dec1982, Vol. 72 Issue 12, p1329; Subject Term: GASTROENTERITIS; Subject Term: VIRAL gastroenteritis; Subject Term: VIRUS diseases; Subject Term: PATHOGENIC microorganisms; Subject Term: PUBLIC health; Subject Term: NURSING care facilities; Subject Term: HEALTH facilities; Subject Term: OLDER people; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: EPIDEMIOLOGY; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Green, Lawrence W.
AU - Wilson, Ronald W.
AU - Bauer, Katherine G.
T1 - Data Requirements to Measure Progress on the Objectives for the Nation in Health Promotion and Disease Prevention.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1983/01//
VL - 73
IS - 1
M3 - Article
SP - 18
EP - 24
PB - American Public Health Association
SN - 00900036
AB - The Reagan Administration has adopted the policy guidelines developed over the previous few years in the disease prevention and health promotion initiative of the Carter Administration. Broad national consensus had been sought in the formulation of 226 measurable objectives for the decade. We classify the prevention objectives according to their position in an implied causal chain: 1) improved programs, 2) increased public and professional awareness, 3) reduced risk factors, and 4) improved health status. Prior to 1980, the data systems and periodic surveys sponsored by federal agencies and national organizations covered only four of the 42 objectives in the public and professional awareness category, whereas at least half of the objectives in each of the other three categories were covered by available national data sources, mostly federal. Sample surveys are needed to measure the majority of the currently unmeasured objectives in all four categories. Private and state health interview surveys are needed to supplement the federal capacity, especially in the face of federal cutbacks in survey capacity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL policy
KW - PRESIDENTS
KW - GOVERNMENT agencies
KW - HEALTH promotion
KW - PREVENTIVE medicine
KW - HEALTH status indicators
KW - MEDICAL care
KW - RISK perception
KW - HEALTH surveys
KW - PREVENTIVE health services
KW - UNITED States
KW - REAGAN, Ronald, 1911-2004
N1 - Accession Number: 4949136; Green, Lawrence W. 1 Wilson, Ronald W. 2 Bauer, Katherine G. 1; Affiliation: 1: Office of Health Information, Health Promotion, Physical Fitness and Sports Medicine, US Department of Health and Human Services, Washington, DC 2: National Center for Health Statistics, Office of the Assistant Secretary for Health, US Department of Health and Human Services, Washington, DC; Source Info: Jan1983, Vol. 73 Issue 1, p18; Subject Term: MEDICAL policy; Subject Term: PRESIDENTS; Subject Term: GOVERNMENT agencies; Subject Term: HEALTH promotion; Subject Term: PREVENTIVE medicine; Subject Term: HEALTH status indicators; Subject Term: MEDICAL care; Subject Term: RISK perception; Subject Term: HEALTH surveys; Subject Term: PREVENTIVE health services; Subject Term: UNITED States; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: REAGAN, Ronald, 1911-2004; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harkiss, G. D.
AU - Brown, D. L.
AU - Smith, D. J.
AU - Nagington, J.
T1 - Antibody moieties within circulating immune complexes in heart transplant recipients.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1983/01//
VL - 51
IS - 1
M3 - Article
SP - 21
EP - 28
PB - Wiley-Blackwell
SN - 00099104
AB - Circulating immune complexes were isolated from the sera of cardiac allograft recipients by bovine conglutinin/anti-conglutinin co-precipitation, or by gel filtration and protein A-Sepharose affinity chromatography. The antibody moieties within these isolated immune complexes were tested for specificity against heterologous anti-thymocyte globulins by solid phase radioimmunoassay, and bacterial and viral antigens by indirect immunofluorescence. The results showed that in addition to possessing specific antiequine anti-thymocyte globulin antibodies, immune complexes also contained crossreacting antibodies to rabbit anti-thymocyte globulin and vice versa, despite the patients only having received antibody of one species. Similarly, antibodies directed against bacteria or viruses (cytomegalovirus. Herpes simplex virus, Epstein-Barr virus) were found within immune complexes obtained during overt infection, but also where infection was not detected. These results demonstrate the heterogeneous nature of immune complexes in heart transplant sera, and suggest that various stimuli, including ATG therapy, infection and possibly polyclonal B cell activation, may be involved in their generation in cardiac transplantation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - HOMOGRAFTS
KW - TRANSPLANTATION of organs, tissues, etc.
KW - BONE-grafting
KW - ANTIGENS
KW - SERUM
N1 - Accession Number: 16026862; Harkiss, G. D. 1 Brown, D. L. 1 Smith, D. J. 2 Nagington, J. 2; Affiliation: 1: Department of Clinical Immunology, Addenbrooke's Hospital, Cambridge, UK. 2: Public Health Service Laboratory, Addenbrooke's Hospital, Cambridge, UK.; Source Info: Jan1983, Vol. 51 Issue 1, p21; Subject Term: IMMUNOGLOBULINS; Subject Term: HOMOGRAFTS; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: BONE-grafting; Subject Term: ANTIGENS; Subject Term: SERUM; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tanaka, Shiro
AU - Lucas, James B.
T1 - Dermatitis in paperhangers.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1984/01//
VL - 10
IS - 1
M3 - Article
SP - 54
EP - 55
SN - 01051873
AB - Occupational allergic contact dermatitis from chloracetamide in glue was previously reported among housepainters who hang wallpaper using the glue containing this chemical as a biocide. Many kinds of biocidal chemicals are added to paints and wallpaper paste to prevent fouling and mildew formation. A defoaming agent may also be added. Since the general populace hang wallpaper only sporadically, it may not reach a sufficient degree of exposure to cause any dermatological problem. However, full-time paperhangers have continuous exposure to the paste and it's chemical additives which may cause allergic contact dermatitis.
KW - OCCUPATIONAL dermatitis
KW - HOUSE painters
KW - PAPERHANGERS
KW - ADHESIVES
KW - WALLPAPER
KW - SKIN -- Inflammation
KW - CONTACT dermatitis
N1 - Accession Number: 12216978; Tanaka, Shiro 1 Lucas, James B. 2; Affiliation: 1: Division of Surveillance, Hazard Evaluation & Field Studies, National Institute for Occupational Safety and Health Centers for Disease Control, Cincinnati, Ohio 45226, USA. 2: Health Effects Research Laboratory, US Environmental Protection Agency, Cincinnati, Ohio, USA.; Source Info: 1984, Vol. 10 Issue 1, p54; Subject Term: OCCUPATIONAL dermatitis; Subject Term: HOUSE painters; Subject Term: PAPERHANGERS; Subject Term: ADHESIVES; Subject Term: WALLPAPER; Subject Term: SKIN -- Inflammation; Subject Term: CONTACT dermatitis; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325520 Adhesive Manufacturing; NAICS/Industry Codes: 322220 Paper Bag and Coated and Treated Paper Manufacturing; NAICS/Industry Codes: 238320 Painting and Wall Covering Contractors; NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; NAICS/Industry Codes: 444120 Paint and Wallpaper Stores; NAICS/Industry Codes: 416340 Paint, glass and wallpaper merchant wholesalers; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0536.ep12216978
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warshawsky, David
AU - Bingham, Eula
AU - Niemeier, Richard W.
T1 - The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 191
EP - 209
SN - 00984108
AB - An isolated perfused New Zealand rabbit lung preparation was used to investigate the effects of a cocarcinogen, ferric oxide (Fe 2 O 3 ), on the metabolism of benzo[a]pyrene (BaP), a ubiquitous potent carcinogen that has been associated with the increased incidence of human bronchiogenic carcinoma in occupational and urban settings. [ 14 C]‐BaP was administered intratracheally to an isolated perfused lung (IPL) preparation with and without Fe 2 O 3 after intraperitoneal pretreatment of the whole animal with BaP or intratracheal pretreatment of the whole animal with Fe 2 O 3 and/or BaP. BaP and its metabolites were isolated from serial blood samples up to 180 min after administration of [ 14 C]BaP to the IPL. BaP and its metabolites were also isolated from lung tissue, washout fluid, macrophage, and trachea bronchi at the end of the perfusion at 180 min. Patterns of BaP metabolites were determined by chromatographic techniques and liquid scintillation counting. Fe 2 O 3 pretreatment to the whole animal or administration of Fe 2 O 3 to the IPL altered BaP metabolism by the perfused lung. Fe 2 O 3 pretreatment to the whole animal resulted in an increase in the total rate of appearance of metabolites of BaP in the blood (ng/g lung·h), while Fe 2 O 3 administration to the IPL resulted in a decrease in the total rate of appearance of BaP metabolites in the blood and inhibited the effect of pretreatment. Administration of Fe 2 O 3 with BaP to the IPL with or without Fe 2 O 3 pretreatment to the whole animal, or BaP administration to the IPL preceded by Fe 2 O 3 pretreatment to the whole animal, enhanced dihydrodiol formation and depressed formation of water‐soluble metabolites. Since dihydrodiol formation is considered to be the active pathway of BaP metabolism, these data suggest that pulmonary exposure to a known cocarcinogen, Fe 2 O 3 , in the presence of BaP results in increased production of dihydrodiols of BaP, which may be further metabolized to the ultimate carcinogenic form(s) of BaP. Therefore, Fe 2 O 3 can enhance the metabolic activation of BaP by the lung, as well as act as a carrier for penetration and retention of BaP in the lung. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457034; Warshawsky, David 1 Bingham, Eula 2 Niemeier, Richard W. 3; Affiliation: 1: University of Cincinnati, Medical Center, Department of Environmental Health, Kettering Laboratory, Cincinnati, Ohio, 45267 2: University of Cincinnati, Medical Center, Department of Environmental Health, Kettering Laboratory, Cincinnati, Ohio 3: National Institute of Occupational Safety and Health, Cincinnati, Ohio; Source Info: Jan1984, Vol. 14 Issue 2/3, p191; Number of Pages: 19p; Document Type: Article
L3 - 10.1080/15287398409530573
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chou, Ming W.
AU - Fu, Peter P.
T1 - Stereoselective metabolism of 8‐and 9‐fluorobenzo[a]pyrene by rat liver microsomes: Absolute configurations of trans ‐dihydrodiol metabolites.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 211
EP - 223
SN - 00984108
AB - Rat liver microsomal metabolism of 8‐fluorobenzo[a]pyrene (8‐fluoro‐BaP) generated 3‐hydroxy‐8‐fluora‐BaP, 8‐fluoro‐BaP trans‐4,5‐dihydrodiol, and 8‐fluoro‐BaP, 3,6‐quinone as major products. A minor metabolite of 8‐fluoro‐BaP was tentatively assigned as 8‐fluoro‐BaP 9,10‐dihydrodiol. Metabolism of 9‐fluorobenzo[a] pyrene (9‐fluoro‐BaP) gave 3‐hydroxy‐9‐fluoro‐BaP, 9‐fluoro‐BaP trans‐4,5‐dihydrodiol, 9‐fluoro‐BaP trans‐7,8‐dihydrodiol, and 9‐fluoro‐BaP 3,6‐quinone. All three dihydrodiol metabolites were optically active. Comparison of the circular dichroism spectra of BaP 4R,5R‐dihydrodiol, 6‐bromo‐BaP 7R,8R‐dihydrodiol, and 6‐fluoro‐BaP 7R,8R‐dihydrodiol with those of the respective dihydrodiol metabolites allowed assignments of an R,R absolute configuration to the major enantiomers of the three dihydrodiol metabolites. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457035; Chou, Ming W. 1 Fu, Peter P. 1; Affiliation: 1: Carcinogenesis Research Division, National Center for Toxicological Research, Jefferson, Arkansas; Source Info: Jan1984, Vol. 14 Issue 2/3, p211; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/15287398409530574
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Russo, J. M.
AU - Anger, W. K.
AU - Setzer, J. V.
AU - Brightwell, W. S.
T1 - Neurobehavioral assessment of chronic low‐level methyl bromide exposure in the rabbit.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/02/
VL - 14
IS - 2/3
M3 - Article
SP - 247
EP - 255
SN - 00984108
AB - The research reported here was intended to identify the concentration at which methyl bromide begins to produce neurotoxic effects in the rabbit, a species known to be sensitive to this compound. Rabbits were exposed via inhalation to 27 ppm methyl bromide over a period of 8 mo for a total exposure duration of 900 h. Biweekly neuro‐behavioral tests, consisting of the latency rates of the ulnar and sciatic nerves and the amplitude of the eyeblink reflex of the orbicularis oculi muscle, failed to uncover any untoward consequences of the exposures. The rabbits gained weight and otherwise appeared to be healthy. In contrast to reports available in the literature, these findings suggest that long‐term exposures to methyl bromide, in the present concentration range, are tolerated by this species. Also detailed in this report is the course of recovery of a separate group of rabbits previously given subchronic exposures to 65 ppm methyl bromide. These animals developed severe neuromuscular losses and had impaired blink reflexes and body weights. The symptoms partially subsided within 6–8 wk after removal from the exposures, suggesting that recovery from a nonfatal but seriously debilitating exposure is possible. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457038; Russo, J. M. 1 Anger, W. K. 2 Setzer, J. V. 2 Brightwell, W. S. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, 4676 Columbia Parkway, Cincinnati, Ohio, 45226 2: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, Ohio; Source Info: Jan1984, Vol. 14 Issue 2/3, p247; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15287398409530577
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vallyathan, V.
AU - Robinson, V.
AU - Reasor, M.
AU - Stettler, L.
AU - Bernstein, R.
T1 - Comparative in vitro cytotoxicity of volcanic ashes from Mount St. Helens, El Chichon, and Galunggung.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 641
EP - 654
SN - 00984108
AB - Dry sedimented volcanic ash samples from each of three widely separated volcanoes of the “Circum Pacific” region have been subjected to mineralogic analysis and in vitro tests for cytotoxicity. The ash samples from the three different volcanoes varied in particle size, surface area, and concentration of silica. Total crystalline silica in the respirable fraction of ashes was 1.5% (Mount St. Helens, Moses Lake); 1.36% (Galunggung, Bandung‐1); 1.95% (Gallunggung, Bandung‐2); and 1.72% (El Chichon, Tuxtia). Hemolysis as an index of cytotoxicity was measured by in vitro tests on sheep blood erythrocytes and indicated wide differences in hemolytic activity among ash samples. Alveolar macrophage cytosolic (lactate dehydrogenase) and lysosomal (β‐glucuronidase and β‐N‐acetyl glucosaminidase) enzymes were measured as an index of cellular integrity following dust exposure. Hemolysis and release of enzymes from alveolar macrophages were greater with volcanic ash from Galunggung (Bandung‐1) and El Chichon (Tuxtia) than the other ashes. Although crystalline silica induced an effect similar to volcanic ash from Galunggung (Bandung‐1) on the release of enzymes from alveolar macrophages, the hemolytic potency of silica was much greater. Light and electron microscopic observations of dust‐exposed alveolar macrophages indicated that the ash particles were readily phagocytized. These results indicate that volcanic ash is moderately cytotoxic and that exposure may lead to overt reactions and the exacerbation of preexisitng chronic inflammatory processes. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457096; Vallyathan, V. 1 Robinson, V. 2 Reasor, M. 3 Stettler, L. 4 Bernstein, R. 5; Affiliation: 1: Pathology Section, NIOSH, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: West Virginia University, Morgantown, West Virginia 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio 5: Centers for Disease Control, Atlanta, Georgia; Source Info: Jan1984, Vol. 14 Issue 5/6, p641; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/15287398409530614
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rabovsky, Jean
AU - Petersen, Martin R.
AU - Lewis, Trent R.
AU - Marion, Karl J.
AU - Groseclose, Robert D.
T1 - Chronic inhalation of diesel exhaust and coal dust: Effect of age and exposure on selected enzyme activities associated with microsomal cytochrome p‐450 in rat lung and liver.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 655
EP - 666
SN - 00984108
AB - Male Fisher‐344 rats were exposed by inhaltion to low levels of diesel exhaust and coal dust, alone or in combination, or to filtered air, 7 h/d, 5 d/wk for 24 mo. Cyto‐chrome P‐450‐associated benzo[a]pyrene hydroxylase and 7‐ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 mo. Age‐related changes in enzyme activities were observed, but they were not altered by the exposures. When the data were adjusted for age, only one difference was observed. Lung benzo[a]pyrene hydroxylase activity in rats exposed to diesel exhaust and coal dust in combination was lower than that in animals exposed to coal dust alone (2.8 versus 4.4 pmol/min·mg protein). Neither value, however, differed significantly from the filtered‐air controls, and no differences were observed in the other lung and liver activities. The data suggest exposure of the rats to diesel exhaust and/or coal dust had little or no effect on the selected lung and liver cytochrome P‐450 activities under the conditions of the experiment. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457097; Rabovsky, Jean 1 Petersen, Martin R. 2 Lewis, Trent R. 2 Marion, Karl J. 2 Groseclose, Robert D. 2; Affiliation: 1: National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Jan1984, Vol. 14 Issue 5/6, p655; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287398409530615
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Groce, Donald F.
AU - Kimbrough, Renate D.
T1 - Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1984/01/03/
VL - 14
IS - 5/6
M3 - Article
SP - 695
EP - 706
SN - 00984108
AB - Firemaster FF‐1, a polybrominated biphenyl (PBB) mixture, was dissolved in corn oil and given as a dose of 200 mg/kg body weight to Sherman rats on d 7 and 14 of pregnancy. Control rats received equivalent doses of corn oil alone. Selected pups and all dams were killed 1 mo after pups were weaned. A total of 50 male and 50 female offspring per group were followed until they were 2 yr old. The livers of offspring killed at the ages of 2 mo and 2 yr had PBB levels of 2.4 (SD 1.2) and 0.8 (SD 0.65) mg/kg for females and 3.0 (SD 1.6) and 0.6 (SD 0.37) mg/kg for males, respectively. The incidence of hepatocellular carcinomas was 3/51 (5.9%) and 4/41 (9.6%) after 2 yr in females and males, respectively. Hepatocellular carcinomas were not observed among the controls. Neoplastic (hyperplastic) nodules of the liver were present in 9/51 (17.6%) and 2/41 (4.9%) of exposed females and males, respectively, whereas only 2/48 (4.2%) of control females and no control males had neoplastic (hyperplastic) nodules. Body weights were lower in PBB‐exposed rats at ages 1, 6, 12, and 24 mo. Survival rates from birth to weaning were lower in PBB‐exposed pups (89%) than in controls (98%). Mortality was two times higher in PBB‐exposed males (64%) than in control males (32%) after 2 yr. Transplacental PBB exposure and exposure through milk resulted in PBB body burdens in the offspring still measurable at the end of their lifespan. These offspring had increased mortality rates and lower body weights than controls, and they developed hepatocellular carcinomas. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457100; Groce, Donald F. 1 Kimbrough, Renate D. 2; Affiliation: 1: Clinical Chemistry Division, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 2: Office of the Director, Center for Environmental Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, 30333; Source Info: Jan1984, Vol. 14 Issue 5/6, p695; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15287398409530618
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Olins, Nancy J.
T1 - Utility of Drug Leaflets for Elderly Consumers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/02//
VL - 74
IS - 2
M3 - Article
SP - 157
EP - 158
PB - American Public Health Association
SN - 00900036
AB - A mail survey of 1,650 elderly consumers evaluated prescription drug leaflets for antihypertensives, tranquilizers, and arthritis medicines. Of those who said they received the leaflet, 95 per cent read it, 76 per cent kept it, and 56 per cent discussed it with another person. Respondents taking antihypertensive medicine were more apt to keep the leaflet and say they learned new information from it. Those taking tranquilizers were less likely to say the leaflet made them feel better about using the drug. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOPOEIAS
KW - TRANQUILIZING drugs
KW - SOCIAL science research
KW - ANTIHYPERTENSIVE agents
KW - CARDIOVASCULAR agents
KW - UNITED States
N1 - Accession Number: 4953199; Morris, Louis A. 1 Olins, Nancy J. 2; Affiliation: 1: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857 2: American Association of Retired Persons Pharmacy Service; Source Info: Feb1984, Vol. 74 Issue 2, p157; Subject Term: PHARMACOPOEIAS; Subject Term: TRANQUILIZING drugs; Subject Term: SOCIAL science research; Subject Term: ANTIHYPERTENSIVE agents; Subject Term: CARDIOVASCULAR agents; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murphy, Lawrence R.
T1 - Occupational stress management: A review and appraisal.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1984/03//
VL - 57
IS - 1
M3 - Article
SP - 1
EP - 15
PB - Wiley-Blackwell
SN - 03058107
AB - Published and unpublished studies evaluating the merits of occupational stress management are reviewed. Worksite stress management studies are compared along dimensions of type of work group, programme orientation and format, stress management methods, non-specific effects, and long-term maintenance of skills and benefits. Although studies differ widely on these dimensions and too few studies have been conducted to state unequivocally general conclusions, worksite stress management programmes appear to offer promise for helping workers cope with stress and exert greater control over physiological and psychological systems which are reactive to stressors. Troublesome issues in this young research area are noted and future research needs are enumerated. Finally, the advantages and potential disadvantages of worksite stress management programmes are described. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB stress
KW - STRESS management
KW - ORGANIZATIONAL structure
KW - TEAMS in the workplace
KW - MENTAL health
KW - PSYCHOLOGY
N1 - Accession Number: 4618455; Murphy, Lawrence R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Source Info: Mar1984, Vol. 57 Issue 1, p1; Subject Term: JOB stress; Subject Term: STRESS management; Subject Term: ORGANIZATIONAL structure; Subject Term: TEAMS in the workplace; Subject Term: MENTAL health; Subject Term: PSYCHOLOGY; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Ringen, Knut
T1 - Notification of Workers at High Risk An Emerging Public Health Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/05//
VL - 74
IS - 5
M3 - Article
SP - 485
EP - 491
PB - American Public Health Association
SN - 00900036
AB - During the last two decades, an increasing number of epidemiologic studies have found cohorts of workers to be at high risk or work-related chronic diseases, especially cancers. These studies frequently have led to the broad recognition of occupational hazards and eventually to the prevention of exposures to such hazards. Generally, however, the individual cohort members found to be at high risk have not been notified of study results, and programs of medical intervention or of palliative services directed at these individual workers have not been developed. Recently, the issue of whether or not workers have a right to be notified more directly about know health hazards to which they may have been exposed has emerged as a major, unresolved question in public health policy. Issues of concern include the criteria that should guide notifications; whom, when, and how to notify; and who should pay for notification and follow-up services. This commentary discusses the scientific, ethical, economic, and institutional aspects of worker notification, and describes three new demonstration projects that have provided notification and intervention for workers at high risk of bladder, colon, and lung cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL hazards
KW - OCCUPATIONAL health services
KW - PUBLIC health
KW - MEDICAL policy
KW - MEDICAL care
N1 - Accession Number: 4958846; Schulte, Paul A. 1 Ringen, Knut 2; Affiliation: 1: Epidemiologist, Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226 2: National Cancer Institute, Division of Resources, Center and Community Activities, Bethesda, MD; Source Info: May84, Vol. 74 Issue 5, p485; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL hazards; Subject Term: OCCUPATIONAL health services; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: MEDICAL care; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snippe, H.
AU - Van Houte, A. J.
AU - Inman, J. K.
AU - Lizzio, Elaine F.
AU - Merchant, B.
T1 - Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.
JO - Immunology
JF - Immunology
Y1 - 1984/05//
VL - 52
IS - 1
M3 - Article
SP - 87
EP - 96
PB - Wiley-Blackwell
SN - 00192805
AB - CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N × C3H/HeN F1 male > CBA/N female > CBA/N · C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTENS
KW - B cells
KW - ANTIGENS
KW - IMMUNE response
KW - THYMUS
KW - CELL populations
KW - MICE
N1 - Accession Number: 13506619; Snippe, H. 1 Van Houte, A. J. 1 Inman, J. K. 2 Lizzio, Elaine F. 3 Merchant, B. 3; Affiliation: 1: Department of Immunology, Laboratory of Microbiology, State University of Utrecht, The Netherlands 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, U.S.A. 3: Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: May84, Vol. 52 Issue 1, p87; Subject Term: HAPTENS; Subject Term: B cells; Subject Term: ANTIGENS; Subject Term: IMMUNE response; Subject Term: THYMUS; Subject Term: CELL populations; Subject Term: MICE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bronaugh, Robert L.
AU - Congdon, Elaine R.
T1 - Percutaneous Absorption of Hair Dyes: Correlation with Partition Coefficients.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1984/08//
VL - 83
IS - 2
M3 - Article
SP - 124
EP - 127
SN - 0022202X
AB - A homologous series of hair dyes was selected for percutaneous absorption studies with excised human skin. The permeability constants obtained for the dyes were compared with octanol/water and skin membrane/ water partition coefficients. The compounds examined were: p -phenylenediamine, o -phenylenediamine, 2-ni- tro-p -phenylenediamine, 2-amino-4-nitrophenol, 4- chloro-m -phenylenediamine, and 4-amino-2-nitro- phenol. Skin absorption of the dyes was observed when they were applied in an aqueous solution. With one exception, the octanol/water partition coefficients were in the same rank order as the permeability constants. The determination of the partitioning of the hair dyes between water and either stratum corneum or epidermis was more complex. Preliminary stratum corneum/water partition studies resulted in values that were in the reverse order of skin permeation. When binding of the compounds to components of the membrane was saturated, the partition values more closely duplicated the rank order of permeability of the dyes. Prediction of percutaneous absorption of substances based on their partition coefficients may he confounded if these compounds are capable of binding to skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN absorption
KW - HAIR -- Dyeing & bleaching
KW - HAIR care products
KW - PARTITION coefficient (Chemistry)
KW - SOLUTION (Chemistry)
KW - PERMEABILITY
KW - SKIN
N1 - Accession Number: 12263302; Bronaugh, Robert L. 1 Congdon, Elaine R. 1; Affiliation: 1: Dermal and Ocular Toxicology Branch, Food and Drug Administration, Washington, D. C., U.S.A.; Source Info: Aug84, Vol. 83 Issue 2, p124; Subject Term: SKIN absorption; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: HAIR care products; Subject Term: PARTITION coefficient (Chemistry); Subject Term: SOLUTION (Chemistry); Subject Term: PERMEABILITY; Subject Term: SKIN; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1523-1747.ep12263302
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor, Philip R.
AU - Lawrence, Charles E.
AU - Ho-Ling Hwang
AU - Paulson, Albert S.
T1 - Polychlorinated Biphenyls: Influence on Birthweight and Gestation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/10//
VL - 74
IS - 10
M3 - Article
SP - 1153
EP - 1154
PB - American Public Health Association
SN - 00900036
AB - Abstract: Fifty-one infants born to women employed at two capacitor manufacturing facilities with a history of high exposure to polychlorinated biphenyls (PCBs) had a mean birthweight of 153 grams < that of 337 infants born to women who had worked in low-exposure areas (90 per ¢ confidence interval, -286 to -20 g): mean gestational age was 6.6 days shorter in the high-exposure infants (90 per ¢ CI, -10.3 to -2.9 days). After adjusting for gestational age. the difference in birthweight was markedly reduced. indicating that the observed reduction in birthweight was due mainly to shortening of gestational age in the high-exposure group. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCHLORINATED biphenyls
KW - BIRTH weight
KW - INFANTS -- Care
KW - GESTATIONAL age
KW - MOTHER & infant
KW - PREGNANCY
KW - CHILDBIRTH
KW - INFANTS
KW - INFANT health services
N1 - Accession Number: 4956365; Taylor, Philip R. 1,2 Lawrence, Charles E. 1 Ho-Ling Hwang 1,3 Paulson, Albert S. 1,3; Affiliation: 1: Director, Statistical and Computer Science Laboratory, New York State Department of Health, Center for Laboratories and Research, Empire State Plaza, Rm C323, Albany, NY 12201 2: National Institute for Occupational Safety and Health, Center for Disease Control and Harvard School of Public Health 3: Rensselaer Polytechnic Institute, Troy, NY; Source Info: Oct84, Vol. 74 Issue 10, p1153; Subject Term: POLYCHLORINATED biphenyls; Subject Term: BIRTH weight; Subject Term: INFANTS -- Care; Subject Term: GESTATIONAL age; Subject Term: MOTHER & infant; Subject Term: PREGNANCY; Subject Term: CHILDBIRTH; Subject Term: INFANTS; Subject Term: INFANT health services; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Grossman, Ruth
AU - Barkdoll, Gerald L.
AU - Gordon, Evelyn
AU - Soviero, Carmin
T1 - A Survey of Patient Sources of Prescription Drug Information.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1984/10//
VL - 74
IS - 10
M3 - Article
SP - 1161
EP - 1162
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national telephone survey of 1,104 adults who had recently obtained a new prescription was undertaken to determine the nature and amount of drug information obtained. Sixty percent stated that physicians provided directions for use information with the pharmacy reported as about half as active. Only 3 to 6 per ¢ said they asked the physician or pharmacist for information, However, one in six respondents said they looked up the prescription in a drug reference book such as the Physicians Desk Reference. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRESCRIPTION of drugs
KW - MEDICAL care surveys
KW - MEDICINE
KW - MEDICAL care
KW - PHARMACEUTICAL services
KW - DRUGS
KW - PHYSICIANS
KW - PHARMACISTS
KW - REFERENCE books
N1 - Accession Number: 4956413; Morris, Louis A. 1 Grossman, Ruth 1 Barkdoll, Gerald L. 1 Gordon, Evelyn 1 Soviero, Carmin 1; Affiliation: 1: Food and Drug Administration, Rockville, MD; Source Info: Oct84, Vol. 74 Issue 10, p1161; Subject Term: PRESCRIPTION of drugs; Subject Term: MEDICAL care surveys; Subject Term: MEDICINE; Subject Term: MEDICAL care; Subject Term: PHARMACEUTICAL services; Subject Term: DRUGS; Subject Term: PHYSICIANS; Subject Term: PHARMACISTS; Subject Term: REFERENCE books; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robinson, C. J. Goter
AU - Abraham, A. A.
AU - Balaza, T.
T1 - Induction of anti-nuclear antibodies by mercuric chloride in mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1984/11//
VL - 58
IS - 2
M3 - Article
SP - 300
EP - 306
PB - Wiley-Blackwell
SN - 00099104
AB - Mercuric chloride (HgCl2) was administered parentetally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4, Inbred A/J male mice were resistant to the induction of ANA by HgCl2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MERCURIC chloride
KW - MICE as laboratory animals
KW - CHLORIDES
KW - MERCURY compounds
KW - LABORATORY animals
KW - anti-nuclear
KW - antibodies
KW - mercuric chloride.
N1 - Accession Number: 16437359; Robinson, C. J. Goter 1,2 Abraham, A. A. 3 Balaza, T. 1,2; Affiliation: 1: Division of Drug Biology, Center for Drug, George Washington University Medical Center, Washington, DC, USA. 2: Biologics, Food and Drug Administration, George Washington University Medical Center, Washington, DC, USA. 3: Department of Pathology, George Washington University Medical Center, Washington, DC, USA.; Source Info: Nov1984, Vol. 58 Issue 2, p300; Subject Term: IMMUNOGLOBULINS; Subject Term: MERCURIC chloride; Subject Term: MICE as laboratory animals; Subject Term: CHLORIDES; Subject Term: MERCURY compounds; Subject Term: LABORATORY animals; Author-Supplied Keyword: anti-nuclear; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: mercuric chloride.; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Robert L.
T1 - Vehicular Carbon Monoxide Screening: Identification in a Cross-Cultural Setting of a Substantial Public Health Risk Factor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/01//
VL - 75
IS - 1
M3 - Article
SP - 85
EP - 86
PB - American Public Health Association
SN - 00900036
AB - Abstract: A community program of screening and education for prevention of vehicular carbon monoxide (CO) poisoning among a high-risk population in a cross-cultural setting is presented. The program was developed after two infant deaths in separate incidents of vehicular CO poisoning. The results of the screening show l8.6 per ¢ of vehicles exceeding the Environmental Protection Agency eight-hour standard for CO exposure, and 2.6 per ¢ exceeding the one-hour standard. Extension of such programs to other high-risk populations is recommended. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON monoxide -- Physiological effect
KW - ENVIRONMENTAL protection -- Standards
KW - ENVIRONMENTAL protection -- Research
KW - DISEASES -- Risk factors
KW - ENVIRONMENTAL policy
KW - ENVIRONMENTAL law
KW - PUBLIC health
KW - ENVIRONMENTAL sciences
KW - CROSS-cultural studies
N1 - Accession Number: 4949545; Williams, Robert L. 1; Affiliation: 1: Navajo Area, Indian Health Service, US Public Health Service, PHS Indian Hospital, Crownpoint, NM 87313.; Source Info: Jan1985, Vol. 75 Issue 1, p85; Subject Term: CARBON monoxide -- Physiological effect; Subject Term: ENVIRONMENTAL protection -- Standards; Subject Term: ENVIRONMENTAL protection -- Research; Subject Term: DISEASES -- Risk factors; Subject Term: ENVIRONMENTAL policy; Subject Term: ENVIRONMENTAL law; Subject Term: PUBLIC health; Subject Term: ENVIRONMENTAL sciences; Subject Term: CROSS-cultural studies; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wallace, W. E.
AU - Vallyathan, V.
AU - Keane, M. J.
AU - Robinson, V.
T1 - In vitro biologic toxicity of native and surface‐modified silica and kaolin.
JO - Journal of Toxicology & Environmental Health
JF - Journal of Toxicology & Environmental Health
Y1 - 1985/01/02/
VL - 16
IS - 3/4
M3 - Article
SP - 415
EP - 424
SN - 00984108
AB - An in vitro study of the biologic responses of surface‐modified and native silica and kaolin was made to provide comparative information on the supression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (LDH), and lysosomal enzymes β‐N‐acetylglucosaminidase (β‐NAG) and β‐glucuronidase (β‐GLUC) and sheep blood‐cell hemolysis were monitored as indicators of cell membrane damage and cytotoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (DPL) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Toxicology & Environmental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75457199; Wallace, W. E. 1 Vallyathan, V. 2 Keane, M. J. 2 Robinson, V. 2; Affiliation: 1: NIOSH, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Jan1985, Vol. 16 Issue 3/4, p415; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287398509530751
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bergeisen, Gershon H.
AU - Hinds, M. Ward
AU - Skaggs, Joseph W.
T1 - A Waterborne Outbreak of Hepatitis A in Meade County, Kentucky.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/02//
VL - 75
IS - 2
M3 - Article
SP - 161
EP - 164
PB - American Public Health Association
SN - 00900036
AB - Abstract: In November 1982. Meade County. Kentucky health officials noted a sudden increase in the incidence of hepatitis A. Using a standardized interview of 73 cases (68 serologically confirmed), and 85 controls (all negative for antibody to hepatitis A virus), the most important risk factor identified was household use of untreated water from a single spring. A dose-response relationship was found for consumption of unboiled spring water, Water samples taken from the spring during the outbreak were contaminated with fecal coliforms. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A
KW - DISEASES -- Risk factors
KW - WATER pollution
KW - CONTAMINATION of drinking water
KW - BACTERIAL pollution of water
KW - KENTUCKY
N1 - Accession Number: 4949444; Bergeisen, Gershon H. 1 Hinds, M. Ward 2 Skaggs, Joseph W. 2; Affiliation: 1: Indian Health Service, Bemidji, MN 2: Department for Health Services, Cabinet for Human Resources, Commonwealth of Kentucky, 275 E. Main Street, Frankfort, KY 40621; Source Info: Feb1985, Vol. 75 Issue 2, p161; Subject Term: HEPATITIS A; Subject Term: DISEASES -- Risk factors; Subject Term: WATER pollution; Subject Term: CONTAMINATION of drinking water; Subject Term: BACTERIAL pollution of water; Subject Term: KENTUCKY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hinds, M. Ward
AU - Skaggs, Joseph W.
AU - Bergeisen, Gershon H.
T1 - Benefit-Cost Analysis of Active Surveillance of Primary Care Physicians for Hepatitis A.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/02//
VL - 75
IS - 2
M3 - Article
SP - 176
EP - 177
PB - American Public Health Association
SN - 00900036
AB - Abstract: We identified two random samples of 216 primary care physicians each. In one sample, we made weekly telephone contact for active hepatitis A (HA) surveillance; in the other, we made no such contact (passive surveillance). Appropriate county hearth departments were notified whenever we identified a HA case by active surveillance. Active surveillance was associated with a 2.8-fold increase in reported HA cases compared to passive surveillance. The estimated benefit: cost ratio active/passive surveillance was 2.5:1. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY care (Medicine)
KW - COST effectiveness
KW - HEPATITIS A
KW - COUNTY health services
KW - COMMUNITY health services
KW - PUBLIC health
N1 - Accession Number: 4949456; Hinds, M. Ward 1 Skaggs, Joseph W. 1 Bergeisen, Gershon H. 1,2; Affiliation: 1: Division for Epidemiology, Kentucky Department for Health Services 2: Indian Health Service, Bemidji, Minnesota; Source Info: Feb1985, Vol. 75 Issue 2, p176; Subject Term: PRIMARY care (Medicine); Subject Term: COST effectiveness; Subject Term: HEPATITIS A; Subject Term: COUNTY health services; Subject Term: COMMUNITY health services; Subject Term: PUBLIC health; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Audet, Michael F.
AU - Johnson, David W.
T1 - Credentialing of Diagnostic X-ray Technologists: A question of Public Health Impact.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/03//
VL - 75
IS - 3
M3 - Article
SP - 270
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper presents estimates of t11,2 number of diagnostic x-ray examinations performed in the United States. the population dose delivered, the percentage of that dose contributed by credentialed and noncredentialed operators, and one measure of performance: collimation of the x-ray beam. An estimated 82 per ¢ of medical x-ray examination:, are performed by voluntarily certified (ARRT or ARCRT) operators. These procedures contribute 90 per ¢ of the radiation dose to the population. Data from the Nationwide Evaluation of X-Ray Trends (NEXT) program indicate that certified operators collimate the x-ray beam somewhat better than noncertified for chest examinations. They also indicate in it difference,; in collimation practices may be attributed to the type of facility as well as to the credentials of the operators. One third of the medical x-ray machines are in states presently requiring licensure of operators. It appears from these estimates that instituting operator licensure in the remaining states may reduce population dose by a maximum of one or two per ¢. (Am J Public Health 1985:75:270-274.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOSCOPIC diagnosis
KW - RADIOLOGIC technologists
KW - RADIOLOGISTS
KW - RADIATION dosimetry
KW - X-ray equipment
KW - MEDICAL personnel -- Licenses
KW - RADIOLOGY
KW - MEDICAL care
KW - RADIOSCOPIC diagnostic equipment industry
KW - UNITED States
N1 - Accession Number: 4948565; Audet, Michael F. 1 Johnson, David W. 1; Affiliation: 1: Center for Device and Radiological Health, US Food and Drug Administration.; Source Info: Mar1985, Vol. 75 Issue 3, p270; Subject Term: RADIOSCOPIC diagnosis; Subject Term: RADIOLOGIC technologists; Subject Term: RADIOLOGISTS; Subject Term: RADIATION dosimetry; Subject Term: X-ray equipment; Subject Term: MEDICAL personnel -- Licenses; Subject Term: RADIOLOGY; Subject Term: MEDICAL care; Subject Term: RADIOSCOPIC diagnostic equipment industry; Subject Term: UNITED States; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volodin, V.
AU - Souchkevitch, G.
AU - Racoveanu, N.
AU - Bergmann, H.
AU - Busemann-Sokole, E.
AU - Delaloye, B.
AU - Dermentzoglou, F.
AU - Georgescu, G.
AU - Herrera, N.
AU - Jasinski, W.
AU - Kasatkin, Y.
AU - Paras, P.
AU - Mould, R.
T1 - World health organisation inter-laboratory comparison study in 12 countries on quality performance of nuclear medicine imaging devices.
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
Y1 - 1985/03//
VL - 10
IS - 5/6
M3 - Article
SP - 193
EP - 197
SN - 03406997
N1 - Accession Number: 71142908; Volodin, V. 1 Souchkevitch, G. 2 Racoveanu, N. 2 Bergmann, H. 3 Busemann-Sokole, E. 4 Delaloye, B. 5 Dermentzoglou, F. 6 Georgescu, G. 7 Herrera, N. 8 Jasinski, W. 9 Kasatkin, Y. 10 Paras, P. 11 Mould, R. 12; Affiliation: 1: Institute of Medical Radiology AMS, Obninsk USSR 2: WHO, Geneva Switzerland 3: Abteilung für Nuklearmedizin 2, Medizinische Universitätsklinik, Vienna Austria 4: University of Amsterdam, The Netherlands 5: Centre Hospitalier Universitaire Vaudois, Lausanne Switzerland 6: Saint Savas Hospital, Athens Greece 7: Institut de Medicina Fizica, Bucharest Romania 8: Danbury Hospital, Danbury USA 9: Post-graduate Medical School, Warsaw Poland 10: Central Institute for Education of Post-graduate Physicians, Moscow USSR 11: National Center for Devices and Radiological Health, USA 12: Westminster Hospital, London UK; Source Info: Mar1985, Vol. 10 Issue 5/6, p193; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/BF00254460
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hurrell Jr., Joseph J.
T1 - Machine-paced work and the Type A behavior pattern.
JO - Journal of Occupational Psychology
JF - Journal of Occupational Psychology
Y1 - 1985/03//
VL - 58
IS - 1
M3 - Article
SP - 15
EP - 25
PB - Wiley-Blackwell
SN - 03058107
AB - This article examines the moderating effects of the Type A behaviour pattern on the relationship between paced work and psychological (mood) disturbance. The study was part of a broader survey investigation seeking to characterize job stress and health relationships among postal workers engaged in machine-paced letter-sorting operations Data from 2803 paced letter sorters and 2715 non-paced Postal Service employees were analysed in a behaviour pattern × pacing × sex (2 × 2 × 2) design. Paced work was found to have a significant effect on mood state. However, no evidence of a Type A moderating effect was found. Results of the study for males but not females were consistent with Sales' (1969) theory that the Type A person possesses personality traits that predispose self-selection into stressful jobs. It was suggested that future studies of the relationships between pacing and the Type A pattern include multiple measures of the behaviour predisposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STRESS (Psychology)
KW - BEHAVIOR
KW - JOB stress
KW - GENDER
KW - INDUSTRIAL psychology
KW - HUMAN behavior
N1 - Accession Number: 4615974; Hurrell Jr., Joseph J. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati.; Source Info: Mar1985, Vol. 58 Issue 1, p15; Subject Term: STRESS (Psychology); Subject Term: BEHAVIOR; Subject Term: JOB stress; Subject Term: GENDER; Subject Term: INDUSTRIAL psychology; Subject Term: HUMAN behavior; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Santaiti, Ben J.
T1 - The Federal Budget Process.
JO - Nursing Economic$
JF - Nursing Economic$
Y1 - 1985/03//Mar/Apr85
VL - 3
IS - 2
M3 - Article
SP - 103
EP - 108
PB - Jannetti Publications, Inc.
SN - 07461739
AB - The article focuses on the need and the development of Federal budget process. When the economic health of the U.S. began to decline a few years ago, increasing attention was focused on the federal budget and the congressional appropriations process. Today, there are three major congressional entities involved in the Federal budget process that ultimately provide cash for disbursements for the numerous government programs. These three entities are legislative spending authorizations, congressional spending resolutions, and appropriations. This article deals mainly with the appropriations part of the process.
KW - BUDGET process
KW - PUBLIC finance
KW - MEDICAL care
KW - DISBURSEMENTS
KW - UNITED States -- Appropriations & expenditures
KW - UNITED States
N1 - Accession Number: 12133062; Santaiti, Ben J. 1; Affiliation: 1: Financial Management Officer, Bureau of Health Professions, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD.; Source Info: Mar/Apr85, Vol. 3 Issue 2, p103; Subject Term: BUDGET process; Subject Term: PUBLIC finance; Subject Term: MEDICAL care; Subject Term: DISBURSEMENTS; Subject Term: UNITED States -- Appropriations & expenditures; Subject Term: UNITED States; NAICS/Industry Codes: 921130 Public Finance Activities; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horan, John M.
AU - Kurt, Thomas L.
AU - Landrigan, Philip J.
AU - Melius, James M.
AU - Singal, Michael
T1 - Neurologic Dysfunction From Exposure to 2-t-Butylazo-2-Hydroxy-5-Methylhexane (BHMH): A New Occupational Neuropathy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/05//
VL - 75
IS - 5
M3 - Article
SP - 513
EP - 517
PB - American Public Health Association
SN - 00900036
AB - Seven cases of subacute central and peripheral neurologic dysfunction developed in 18 workers employed in the manufacture of reinforced plastic bathtubs. Cases were characterized by weight loss, dizziness, paresthesias, muscle weakness, incontinence, memory loss, and loss of peripheral, color, and night vision. Neuropathies began distally, involved both sensory and motor function, and were associated with prolonged sensory latency, muscle fibrillation, and reduced numbers of functioning motor units. One patient developed posterior lenticular cataracts. Story improvement occurred on removal from exposure, but residual neuropathies persisted for as long as two year. Epidemiologic investigation disclosed that the first case developed approximately two weeks after introduction of it new plastic foaming agent. 2-t-butylazo-2hydroxy-5-methylhexane (BHMH). All cases occurred in workers exposed directly to BHMH. No new cases developed after use of BHMH was discontinued. A survey of the firm which produced BHMH and of 68 user firms found two additional clusters of mild neuropathy which may have been caused by BHMH. BHMH was withdrawn from distribution following discovery of these cases. Subsequently. BHMH has been shown in rats to be a potent neurotoxin. Adequate premarket testing could have averted this outbreak. (Am J Public Health 1985, 75:513-517.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROPATHY
KW - NERVOUS system -- Diseases
KW - NEUROLOGIC manifestations of general diseases
KW - INDUSTRIAL workers
KW - INDUSTRIAL safety
KW - EMPLOYEE health promotion
KW - ALIPHATIC compounds
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 4949303; Horan, John M. 1 Kurt, Thomas L. 2 Landrigan, Philip J. 1 Melius, James M. 1 Singal, Michael 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Acid Studies, National Institute for Occupational Safety and Health, Cincinnati. 2: Department of Internal Medicine, University of Tens Health Science Center and North Central Texas Poison Center, Parkland Memorial Hospital, Dallas.; Source Info: May85, Vol. 75 Issue 5, p513; Subject Term: NEUROPATHY; Subject Term: NERVOUS system -- Diseases; Subject Term: NEUROLOGIC manifestations of general diseases; Subject Term: INDUSTRIAL workers; Subject Term: INDUSTRIAL safety; Subject Term: EMPLOYEE health promotion; Subject Term: ALIPHATIC compounds; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Budnick, Lawrence D.
AU - Ross, David A.
T1 - Bathtub-Related Drownings in the United States, 1979-81.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/06//
VL - 75
IS - 6
M3 - Article
SP - 630
EP - 633
PB - American Public Health Association
SN - 00900036
AB - We analyzed National Center for Health Statistics data on drownings in bathtubs and Consumer Product Safety Commission data on bathtub-related injuries for the years 1979-80 and 1979-81, respectively. Seven hundred ten persons drowned in bathtubs in 1979 and 1980, for a crude mortality rate of 1.6 per million persons per year. Although there was an excess of deaths in the spring, there was no important seasonal trend. Mortality rates in the Pacific and Mountain states were higher than in other states. Persons at the extremes of age were al greatest risk of death, with mortality rates of 5-6 per million per year, Black males aged 20-64 years had substantially elevated mortality rates compared to White males. The prevalence of personal risk indicators varied with age, with a frequent history of being left unattended among children less than 5 years old, a frequent history of seizures among persons 5-39 years old, and frequent history of alcohol or drug use among persons 40-59 years old, and frequent evidence of having fallen among those at least 60 years old. Bathtubs are potentially dangerous, and the prevention of drownings in them can be approached through a combination of passive and active strategies. (Am J Public Health 1985: 75:630-633.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DROWNING
KW - ACCIDENTS
KW - DEATH -- Causes
KW - BATHTUBS
KW - PRODUCT safety
KW - GOVERNMENT agencies
KW - UNITED States
KW - U.S. Consumer Product Safety Commission
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4949373; Budnick, Lawrence D. 1 Ross, David A. 1; Affiliation: 1: Special Studies Branch, Chronic Diseases Division, Center for Environmental Health, Center for Disease Control, Public Health Services, US Department of Health and Human Services, Atlanta, Georgia 30333.; Source Info: Jun85, Vol. 75 Issue 6, p630; Subject Term: DROWNING; Subject Term: ACCIDENTS; Subject Term: DEATH -- Causes; Subject Term: BATHTUBS; Subject Term: PRODUCT safety; Subject Term: GOVERNMENT agencies; Subject Term: UNITED States; Company/Entity: U.S. Consumer Product Safety Commission Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 238390 Other Building Finishing Contractors; NAICS/Industry Codes: 416120 Plumbing, heating and air-conditioning equipment and supplies merchant wholesalers; NAICS/Industry Codes: 326191 Plastics Plumbing Fixture Manufacturing; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cafferata, Gail Lee
T1 - The Elderly's Private Insurance Coverage of Nursing Home Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/06//
VL - 75
IS - 6
M3 - Article
SP - 655
EP - 656
PB - American Public Health Association
SN - 00900036
AB - About 40 per cent of Medicare beneficiaries had private insurance coverage of skilled nursing facilities (SNF) in 1977. Data from the 1977 National Medical Care Expenditure Survey show that among such persons, about 85 per cent had full coverage of Medicare's Part A copayments for days 21-100 but only 15.7 per cent had maximum coverage of at least 365 days of care or a benefit of $100.000 or more. The most comprehensive benefits are found among persons with middle or high incomes: more generous first-dollar coverage is found in the North Central and South regions, and more generous maximums in the West. (Am d Public Health 1985; 75:655-656.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE
KW - HEALTH insurance
KW - MEDICARE beneficiaries
KW - OLDER people -- Care
KW - NURSING care facilities
KW - HEALTH facilities
KW - NURSING home care
KW - LONG-term care of the sick
KW - UNITED States
N1 - Accession Number: 4949393; Cafferata, Gail Lee 1; Affiliation: 1: Sociologist, National Center for Health Services Research and Health Care Technology Assessment (NCHRS), US Department of Health and Human Services, 5600 Fishers Lane 3-50, Rockville, MD 20857.; Source Info: Jun85, Vol. 75 Issue 6, p655; Subject Term: MEDICARE; Subject Term: HEALTH insurance; Subject Term: MEDICARE beneficiaries; Subject Term: OLDER people -- Care; Subject Term: NURSING care facilities; Subject Term: HEALTH facilities; Subject Term: NURSING home care; Subject Term: LONG-term care of the sick; Subject Term: UNITED States; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Broido, Michelle S.
AU - James, Thomas L.
AU - Zon, Gerald
AU - Keepers, Joe W.
T1 - Investigation of the solution structure of a DNA octamer [d(GGAATTCC)]2 using two-dimenstional nuclear Overhauser enhancement spectroscopy.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/07//7/1/85
VL - 150
IS - 1
M3 - Article
SP - 117
EP - 128
PB - Wiley-Blackwell
SN - 00142956
AB - Proton two-dimensional nuclear Overhauser enhancement (2D NOE) spectra in the pure absorption phase were obtained at 500 MHz for [d(GGAATTCC)]2 in aqueous solution at a series of mixing times. The experimental data were analyzed by comparison with theoretical spectra calculated using the complete 70 × 70 relaxation matrix including all proton dipole-dipole interactions and spin diffusion [Keepers, J. W. & James, T. L. (1984) J. Magn. Resort. 57, 404–426]. The theoretical spectra at each mixing time were calculated using two structures: a standard B-form DNA structure and an energy-minimized structure based on the similarity of the six internal residues of the title octamer with those of the dodecamer [d(CGCGAATTCGCG)]2, for which the crystal structure has been determined. Neither the standard B-form nor the energy-minimized structure will yield theoretical 2D NOE spectra which accurately reproduce all peak intensities in the experimental spectra. However, many features of the experimental spectra can be represented by both the B-form and the energy-minimized structure. Sequence-dependent structural characteristics are manifest in the 2D NOE spectra, in particular at the purine-pyrimidine junction as noted previously in the crystal structure. On the whole, the energy-minimized structure appears to yield theoretical 2D NOE spectra which mimic many, if not all, aspects of the experimental spectra. All 2D NOE data were consistent with nanosecond correction times as implied by proton spin-lattice relaxation time measurements. But better fits of some of the 2D NOE data using small variations in an effective isotropic correlation time suggest that there may be some local variations in mobility within the octamer duplex structure in solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA synthesis
KW - SPIN-lattice relaxation
KW - NUCLEAR magnetic resonance
KW - DIPOLE moments
KW - PHOTON echoes
KW - PURINES
KW - PYRIMIDINES
N1 - Accession Number: 13871945; Broido, Michelle S. 1 James, Thomas L. 2 Zon, Gerald 3 Keepers, Joe W. 4; Affiliation: 1: Department of Chemistry, Hunter College and Graduate Center of the City University of New York 2: Departments of Pharmaceutical Chemistry and Radiology, Schools of Pharmacy and Medicine, University of California, San Francisco 3: National Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland 4: Department of Chemistry, Rutgers University, New Brunswick, New Jersey; Source Info: 7/1/85, Vol. 150 Issue 1, p117; Subject Term: DNA synthesis; Subject Term: SPIN-lattice relaxation; Subject Term: NUCLEAR magnetic resonance; Subject Term: DIPOLE moments; Subject Term: PHOTON echoes; Subject Term: PURINES; Subject Term: PYRIMIDINES; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Attico, N. Burton
AU - Smith III, Richard J.
AU - FitzPatrick, Michael B.
AU - Keneally, Michael
AU - Friedman, Michael A.
T1 - Auto Seat Belts: Good Prenatal, Postpartum, and Infant Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/08//
VL - 75
IS - 8
M3 - Letter
SP - 892
EP - 893
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article on the use of seat belts by pregnant women to reduce serious injuries and death.
KW - LETTERS to the editor
KW - AUTOMOBILE seat belts
N1 - Accession Number: 21096259; Attico, N. Burton 1 Smith III, Richard J. 1 FitzPatrick, Michael B. 1 Keneally, Michael 1 Friedman, Michael A. 1; Affiliation: 1: Phoenix Area Indian Health Service, 3738 No. Sixteenth Street, Suite #A, Phoenix, AZ; Source Info: Aug1985, Vol. 75 Issue 8, p892; Subject Term: LETTERS to the editor; Subject Term: AUTOMOBILE seat belts; NAICS/Industry Codes: 316998 All Other Leather Good and Allied Product Manufacturing; NAICS/Industry Codes: 326220 Rubber and Plastics Hoses and Belting Manufacturing; NAICS/Industry Codes: 336360 Motor Vehicle Seating and Interior Trim Manufacturing; NAICS/Industry Codes: 415290 Other new motor vehicle parts and accessories merchant wholesalers; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Grimes, David A.
AU - Peterson, Herbert B.
T1 - On Risks, Costs of Sterilization.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/10//
VL - 75
IS - 10
M3 - Letter
SP - 1230
EP - 1230
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Comparative Risks and Costs of Male and Female Sterilization," by Gregory L. Smith and George P. Taylor.
KW - LETTERS to the editor
KW - STERILIZATION (Disinfection)
N1 - Accession Number: 21096150; Grimes, David A. 1 Peterson, Herbert B. 1; Affiliation: 1: DHHS, Public Health Service, Centers for Disease Control, Atlanta, GA 30333; Source Info: Oct85, Vol. 75 Issue 10, p1230; Subject Term: LETTERS to the editor; Subject Term: STERILIZATION (Disinfection); Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jamin, Nadege
AU - James, Thomas L.
AU - Zon, Gerald
T1 - Two-dimensional nuclear Overhauser enhancement investigation of the solution structure and dynamics of the DNA octamer [d(GGTATACC)]2.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1985/10//10/1/85
VL - 152
IS - 1
M3 - Article
SP - 157
EP - 166
PB - Wiley-Blackwell
SN - 00142956
AB - The resonances of nearly all 70 of the non-exchangeable protons of the duplex [d(GGTATACC)]2 in aqueous solution are assigned by proton two-dimensional nuclear Overhauser enhancement (2D NOE) spectra obtained in pure absorption phase at 500 MHz. Experimental and theoretical 2D NOE spectra are compared at each mixing time (100, 175, 250 and 400 ms) using two B-DNA structures: a standard B-form and an energy-minimized form. The GG and CC ends of the octamer duplex are well represented by the regular B-DNA structure. But large discrepancies from these models are observed for the ‘TATA’ box. All 2D NOE data are consistent with nanosecond correlation times, as indicated by non-selective proton spin-lattice relaxation times, but small variations in the correlation time are observed, suggesting that there are some local differences in mobility within the octamer duplex structure in solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVERHAUSER effect (Nuclear physics)
KW - SPIN-lattice relaxation
KW - NUCLEAR magnetic resonance
KW - DNA
KW - PROTONS
KW - OLIGONUCLEOTIDES
N1 - Accession Number: 13873484; Jamin, Nadege 1 James, Thomas L. 1 Zon, Gerald 2; Affiliation: 1: Departments of Pharmaceutical Chemistry and Radiology, Schools of Pharmacy and Medicine, University of California, San Francisco 2: Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland; Source Info: 10/1/85, Vol. 152 Issue 1, p157; Subject Term: OVERHAUSER effect (Nuclear physics); Subject Term: SPIN-lattice relaxation; Subject Term: NUCLEAR magnetic resonance; Subject Term: DNA; Subject Term: PROTONS; Subject Term: OLIGONUCLEOTIDES; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schaeffer, Morris
T1 - William H. Park (1863-1939): His Laboratory and His Legacy.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1985/11//
VL - 75
IS - 11
M3 - Article
SP - 1296
EP - 1302
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the works of U.S. bacteriologist William H. Park during the 19th and early 20th centuries. Park's interest in the high infant mortality rate from the consumption of heavily contaminated milk turned him into the leading authority in the development of methods for the bacterial control of milk supplies. He was also known for being among the first to recognize the existence of healthy carriers of microbial agents. He urged New York financier Jeremiah Milbank to support the establishment of the International Committee for the Study of Infantile Paralysis in 1928.
KW - BACTERIOLOGISTS
KW - INFANT mortality
KW - COMMUNICABLE diseases -- Transmission
KW - POLIO
KW - UNITED States
KW - PARK, William H.
N1 - Accession Number: 4947440; Schaeffer, Morris 1; Affiliation: 1: Center for Drugs and Biologics, Food and Drug Administration; Source Info: Nov85, Vol. 75 Issue 11, p1296; Subject Term: BACTERIOLOGISTS; Subject Term: INFANT mortality; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: POLIO; Subject Term: UNITED States; People: PARK, William H.; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nutting, Paul A.
AU - Connor, Eileen M.
T1 - Community-oriented Primary Care: An Examination of the US Experience.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/03//
VL - 76
IS - 3
M3 - Article
SP - 279
EP - 281
PB - American Public Health Association
SN - 00900036
AB - Abstract: Community-oriented primary care (COPC) represents a specific variation on the general primary care model. Seven case studies from vastly different health care settings were examined and this report describes the diversity of expression of the principles of COPC observed. The results suggest that COPC is not limited to publicly funded programs, but can find expression in the private sector as well. The organization of financing and the lack of feasible quantitative tools hinder the full development of the model. (Am J Public Health 1986; 76:279-281.) INSET: Expanded Nurse Training Program Includes Home Health Care. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY health care
KW - COMMUNITY health services -- Finance
KW - HEALTH promotion
KW - HEALTH care intervention (Social services)
KW - MEDICAL care
KW - MEDICAL cooperation
KW - PRIMARY care (Medicine)
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 4729011; Nutting, Paul A. 1 Connor, Eileen M. 2; Affiliation: 1: Director, Office of Primary Care Studies, Health Resources and Services Administration, Room 1325, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857 2: Professional Associate, Institute of Medicine; Source Info: Mar86, Vol. 76 Issue 3, p279; Subject Term: PRIMARY health care; Subject Term: COMMUNITY health services -- Finance; Subject Term: HEALTH promotion; Subject Term: HEALTH care intervention (Social services); Subject Term: MEDICAL care; Subject Term: MEDICAL cooperation; Subject Term: PRIMARY care (Medicine); Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Rorert
T1 - Prevalence of Hepatitis A Virus Antibody among Navajo School Children.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/03//
VL - 76
IS - 3
M3 - Article
SP - 282
EP - 283
PB - American Public Health Association
SN - 00900036
AB - Abstract: Previous studies of the prevalence of immunity to hepatitis A (anti-HAV) in the United States have used urban settings or institutions for the mentally handicapped. In a rural setting among normal children, a serologic investigation of prevalence of anti-HAV was conducted in a boarding school adjacent to the Navajo reservation. The results show rates of anti-HAV that are the highest reported at the ages tested in any subpopulation in the United States, comparable only with those in developing countries. (Am J Public Health 1986; 76:282-283.) INSET: Irradiated What?. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - IMMUNITY
KW - NAVAJO children
KW - DIAGNOSTIC microbiology
KW - SCHOOL children -- Health
KW - ENTEROVIRUSES
KW - CHILDREN
KW - PUBLIC health
KW - NEW Southwest (U.S.)
KW - UNITED States
N1 - Accession Number: 4729057; Williams, Rorert 1; Affiliation: 1: Indian Health Service, PHS Indian Hospital, CrownPoint NM 87313; Source Info: Mar86, Vol. 76 Issue 3, p282; Subject Term: HEPATITIS A virus; Subject Term: IMMUNITY; Subject Term: NAVAJO children; Subject Term: DIAGNOSTIC microbiology; Subject Term: SCHOOL children -- Health; Subject Term: ENTEROVIRUSES; Subject Term: CHILDREN; Subject Term: PUBLIC health; Subject Term: NEW Southwest (U.S.); Subject Term: UNITED States; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coulehan, John L.
AU - Lerner, Guy
AU - Helzlsouer, Kathy
AU - Welty, Thomas K.
AU - McLaughlin, James
T1 - Acute Myocardial Infarction among Navajo Indians, 1976-83.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/04//
VL - 76
IS - 4
M3 - Article
SP - 412
EP - 414
PB - American Public Health Association
SN - 00900036
AB - Abstract: We found that from 1976 through 1983 the incidence of acute myocardial infarction (AMI) diagnosed among Navajo Indians remained low (0.5 per 1,000 persons age 30 years or more), although the incidence in women appears to be climbing. Navajo AMI patients are more likely to be hypertensive and diabetic than age- and sex-matched patients with gallbladder disease. Twenty-four per ¢ die within one month of AMI. (Am J Public Health 1986; 76:412-414.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOCARDIAL infarction
KW - NAVAJO (North American people)
KW - PATIENTS
KW - HYPERTENSION
KW - DIABETICS
KW - GALLBLADDER -- Diseases
KW - PUBLIC health
KW - CORONARY heart disease
KW - NATIVE Americans
N1 - Accession Number: 4686295; Coulehan, John L. 1 Lerner, Guy 1 Helzlsouer, Kathy 1 Welty, Thomas K. 2 McLaughlin, James 2; Affiliation: 1: Department of Community Medicine, M-200 Seaife Hall, University of Pittsburgh School of Medicine Pittsburgh, PA 15261. 2: US Indian Health Service, Navajo Area.; Source Info: Apr1986, Vol. 76 Issue 4, p412; Subject Term: MYOCARDIAL infarction; Subject Term: NAVAJO (North American people); Subject Term: PATIENTS; Subject Term: HYPERTENSION; Subject Term: DIABETICS; Subject Term: GALLBLADDER -- Diseases; Subject Term: PUBLIC health; Subject Term: CORONARY heart disease; Subject Term: NATIVE Americans; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Mary F.
T1 - Discussion: Design and analysis of plaque and gingivitis clinical trials.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1986/05//
VL - 13
IS - 5
M3 - Article
SP - 407
EP - 409
SN - 03036979
AB - The article discusses the design and analysis of plaque and gingivitis clinical trials. The rationale for a proposed design or analytic approach does not properly take into account the over-riding features of the disease or condition under study. A properly designed trial will have a high probability of detecting a good treatment and at the same time, will have a low risk of showing a treatment effective that really is not. The statistical test applied to data from the completed study have adequate power to detect a clinically meaningful difference between the test and placebo groups at some specified significance level.
KW - GINGIVITIS
KW - DENTAL plaque
KW - CLINICAL trials
KW - PROBABILITY theory
KW - STATISTICS
KW - SAMPLE size (Statistics)
N1 - Accession Number: 13602690; Johnson, Mary F. 1; Affiliation: 1: Division of Biometrics, Center for Drugs and Biologics, U.S. Food and Drug Administration, Rockville, MD, USA.; Source Info: May1986, Vol. 13 Issue 5, p407; Subject Term: GINGIVITIS; Subject Term: DENTAL plaque; Subject Term: CLINICAL trials; Subject Term: PROBABILITY theory; Subject Term: STATISTICS; Subject Term: SAMPLE size (Statistics); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1600-051X.ep13602690
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Neill, Robert T .
T1 - Discussion: Considerations in the design and analysis of clinical trials in periodontitis.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1986/05//
VL - 13
IS - 5
M3 - Article
SP - 529
EP - 530
SN - 03036979
AB - The article discusses the design and analysis of clinical trials in periodontitis. There are many areas of chronic disease evaluation where episodic type of events occurs and where one must decide on the measurement and characterization of the disease process and the changes gone through, similar to the discussion of the patterns of destructive periodontal diseases. The major problem is in concluding that a treatment is effective when it is not because of the unreliability, where the assumption has been made that the experimental units are statistically independent when, in fact, they are non-independent.
KW - PERIODONTITIS
KW - CLINICAL trials
KW - CHRONIC diseases
KW - MEDICAL experimentation on humans
KW - PERIODONTAL disease
KW - ORAL hygiene
N1 - Accession Number: 13603769; O'Neill, Robert T . 1; Affiliation: 1: Division of Biometrics, Center for Drugs and Biologicals, Food and Drug Administration, Rockville, MD, USA; Source Info: May1986, Vol. 13 Issue 5, p529; Subject Term: PERIODONTITIS; Subject Term: CLINICAL trials; Subject Term: CHRONIC diseases; Subject Term: MEDICAL experimentation on humans; Subject Term: PERIODONTAL disease; Subject Term: ORAL hygiene; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-051X.ep13603769
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McNelis, Peter J.
T1 - The Military Family: Dynamics and Treatment (Book ).
JO - Social Work
JF - Social Work
Y1 - 1986/05//May/Jun86
VL - 31
IS - 3
M3 - Book Review
SP - 228
EP - 228
PB - Oxford University Press / USA
SN - 00378046
AB - Reviews the book "The Military Family: Dynamics and Treatment," edited by Florence W. Kaslow and Richard I. Ridenour.
KW - FAMILIES of military personnel
KW - NONFICTION
KW - KASLOW, Florence W.
KW - RIDENOUR, Richard I.
KW - MILITARY Family, The (Book)
N1 - Accession Number: 5271532; McNelis, Peter J. 1; Affiliation: 1: U.S. Army-Medical Service Corps. Office of the Surgeon General.; Source Info: May/Jun86, Vol. 31 Issue 3, p228; Subject Term: FAMILIES of military personnel; Subject Term: NONFICTION; Reviews & Products: MILITARY Family, The (Book); People: KASLOW, Florence W.; People: RIDENOUR, Richard I.; Number of Pages: 1/3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rabin, Jack
AU - Keefe, Kathleen
AU - Burton, Michael
T1 - Enhancing Services for Sexual-Minority Clients: A Community Mental Health Approach.
JO - Social Work
JF - Social Work
Y1 - 1986/07//Jul/Aug86
VL - 31
IS - 4
M3 - Article
SP - 294
EP - 298
PB - Oxford University Press / USA
SN - 00378046
AB - The article describes the efforts of the community mental health services to improve services for gay people in San Francisco, California. Sexual-minority clients are reluctant to reveal their homosexuality because they fear discrimination and hostility from health care providers. Indeed, those who have been open about their sexual orientation have often encountered difficulties with health practitioners. The article describes an approach used by a community mental health district to assess its current services for sexual-minority clients, develop recommendations for more appropriate staffing and staff development, and implement a plan of community outreach and professional training. The needs assessment showed that many staff members informally evaluated needs by observing how many clients from a particular ethnic, social, or age group were already using services. The needs assessment, however, revealed some prevailing staff attitudes. Generally, staff seemed reluctant to answer questions or discuss issues related to sexuality.
KW - MENTAL health
KW - GAY people
KW - HOMOSEXUALITY
KW - COMMUNITY health services
KW - HUMAN sexuality
KW - MEDICAL care
N1 - Accession Number: 5281925; Rabin, Jack 1 Keefe, Kathleen Burton, Michael 2; Affiliation: 1: Assistant Clinical Director, Community Mental Health Services, San Francisco, California. 2: Psychiatrist, Oceanview/Merced/lngleside/Parkside Family Center, Community Mental Health Services, San Francisco, California.; Source Info: Jul/Aug86, Vol. 31 Issue 4, p294; Subject Term: MENTAL health; Subject Term: GAY people; Subject Term: HOMOSEXUALITY; Subject Term: COMMUNITY health services; Subject Term: HUMAN sexuality; Subject Term: MEDICAL care; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Sundin, David S.
AU - Pedersen, David H.
AU - Frazier, Todd M.
T1 - Occupational Hazard and Health Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/09//
VL - 76
IS - 9
M3 - Editorial
SP - 1083
EP - 1084
PB - American Public Health Association
SN - 00900036
AB - The author reflects on the many methodological problems encountered in the development of surveillance systems for occupational hazards and illnesses. The goal of a surveillance system must include both hazard and disease surveillance components. However, its development is usually hampered by difficulties with identifying a particular exposure agent. Moreover, the Standard Industrial Classification coding scheme used was not designed to classify industries on the basis of common exposures.
KW - PUBLIC health surveillance
KW - INDUSTRIAL safety
KW - SECURITY systems
KW - OCCUPATIONAL diseases
KW - OCCUPATIONAL hazards
KW - INDUSTRIAL hygiene
KW - EMPLOYEE health promotion
N1 - Accession Number: 4685530; Sundin, David S. 1 Pedersen, David H. 1 Frazier, Todd M. 1; Affiliation: 1: National Institute for Occupational Safety and Health.; Source Info: Sep86, Vol. 76 Issue 9, p1083; Subject Term: PUBLIC health surveillance; Subject Term: INDUSTRIAL safety; Subject Term: SECURITY systems; Subject Term: OCCUPATIONAL diseases; Subject Term: OCCUPATIONAL hazards; Subject Term: INDUSTRIAL hygiene; Subject Term: EMPLOYEE health promotion; NAICS/Industry Codes: 561621 Security Systems Services (except Locksmiths); Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bronaugh, Robert L.
AU - Weingarten, Daniel P.
AU - Lowe, Nicholas J.
T1 - Differential Rates of Percutaneous Absorption Through the Eczematous and Normal Skin of the Monkey.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1986/10//
VL - 87
IS - 4
M3 - Article
SP - 451
EP - 453
SN - 0022202X
AB - A monkey (Macaca fascicularis ), diagnosed as having eczematous dermatitis on the basis of histopathology of a skin biopsy, was used to study the percutaneous absorption of 2 anti-inflammatory steroids. Absorption was measured through involved and uninvolved skin by using in vitro diffusion cell techniques. Hydrocortisone (0.5%) and triamcinolone acetonide (0.1%) were applied to the skin in a petrolatum vehicle. After application for 24 h, the permeation of hydrocortisone was approximately doubled (from 2.6 to 5.5% of the applied dose) when diseased skin was used. The absorption of triamcinolone acetonide was enhanced through the eczematous skin during the initial 12 h. At 24 h, however, no significant difference in total absorption was obtained. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - SKIN -- Inflammation
KW - ECZEMA
KW - PATHOLOGICAL histology
KW - BIOPSY
KW - SKIN tests
N1 - Accession Number: 12455487; Bronaugh, Robert L. 1 Weingarten, Daniel P. 2 Lowe, Nicholas J. 2; Affiliation: 1: Division of Toxicology, Food and Drug Administration, Washington, D. C. 2: Division of Dermatology, Department of Medicine, School of Medicine, University of California, Los Angeles, California, U.S.A.; Source Info: Oct86, Vol. 87 Issue 4, p451; Subject Term: CONTACT dermatitis; Subject Term: SKIN -- Inflammation; Subject Term: ECZEMA; Subject Term: PATHOLOGICAL histology; Subject Term: BIOPSY; Subject Term: SKIN tests; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/1523-1747.ep12455487
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seligman, Paul J.
AU - Halperin, WiIliam E.
AU - Mullan, Robert J.
AU - Frazier, Todd M.
T1 - Occupational Lead Poisoning in Ohio: Surveillance Using Workers' Compensation Data.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/11//
VL - 76
IS - 11
M3 - Article
SP - 1299
EP - 1302
PB - American Public Health Association
SN - 00900036
AB - Abstract: To determine the utility of workers' compensation (WC) data in a system for the surveillance of occupational lead poisoning, we reviewed workers' compensation claims for lead poisoning in Ohio. For the period 1979 through 1983, 92 (81 per ¢) of the 114 claims attributed to lead met our case definition of lead poisoning. The likelihood that a company had a case of lead poisoning was strongly correlated with the number of claims against the company. Thirty companies accounted for the 92 cases; two companies accounted for 49 per ¢ of these. Inspection by the Occupational Safety and Health Administration (OSHA) occurred at 14 of these companies, all of which were cited for violations of the OSHA lead standard. Comparison of the Standard Industrial Classification (SIC) codes for the 14 companies inspected by OSHA with the 15 companies not inspected by OSHA revealed that OSHA inspected battery manufacturers, non-ferrous foundries, secondary smelters, and primary lead smelters, but not bridge painters, manufacturers of electronic components, mechanical power transmission equipment, pumps, and paints, nor a sheriff's office where firing range slugs were remelted to make new bullets. Neither the number of cases of lead poisoning at a company nor the size of a company was related to the likelihood of being inspected by OSHA. Claims for WC appear to be a useful adjunct to an occupational lead poisoning surveillance system; their usefulness should be compared to that of other systems such as laboratory reports of elevated blood lead levels in adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORKERS' compensation
KW - INDUSTRIAL toxicology
KW - COMPENSATION management
KW - HEALTH services administration
KW - HEALTH planning
KW - INDUSTRIAL safety
KW - INDUSTRIAL policy
KW - OHIO
KW - UNITED States. Occupational Safety & Health Administration
N1 - Accession Number: 4686803; Seligman, Paul J. 1 Halperin, WiIliam E. 1 Mullan, Robert J. 1 Frazier, Todd M. 1; Affiliation: 1: Industry-Wide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Services, National Institute for Occupational Safety and Health, NIOSH R-10, 4676, Columbia Parkway, Cincinnati, OH 45226.; Source Info: Nov86, Vol. 76 Issue 11, p1299; Subject Term: WORKERS' compensation; Subject Term: INDUSTRIAL toxicology; Subject Term: COMPENSATION management; Subject Term: HEALTH services administration; Subject Term: HEALTH planning; Subject Term: INDUSTRIAL safety; Subject Term: INDUSTRIAL policy; Subject Term: OHIO; Company/Entity: UNITED States. Occupational Safety & Health Administration; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Louis A.
AU - Klimberg, Ronald
T1 - A Survey of Aspirin Use and Reye's Syndrome Awareness among Parents.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1986/12//
VL - 76
IS - 12
M3 - Article
SP - 1422
EP - 1424
PB - American Public Health Association
SN - 00900036
AB - Abstract: A national telephone survey of 1,155 parents of children 19 years of age and younger solicited patterns of medication use during episodes of childhood flu and chicken pox. During the previous two years, 6 per ¢ of the parents whose children had chicken pox and 16 per ¢ of parents whose children had flu administered aspirin. Approximately 12 per ¢ of the total sample said they would give their child aspirin if their child were to get the flu or chicken pox today. About half (53 per ¢) were aware of the contraindication against aspirin use and 40 per ¢ could spontaneously recall the name Reye's Syndrome (RS). When measured by a recognition test, 84 per ¢ of the sample said they had heard of RS. People who continued to believe that aspirin was an appropriate medication were more likely to have treated older children The RS contraindication for aspirin should be emphasized for teenagers in future public informational programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - CHICKENPOX
KW - ASPIRIN
KW - REYE'S syndrome
KW - ANALGESICS
KW - NONSTEROIDAL anti-inflammatory agents
KW - JUVENILE diseases
KW - CHILD care
KW - MEDICAL care
N1 - Accession Number: 4693190; Morris, Louis A. 1 Klimberg, Ronald 1; Affiliation: 1: Food and Drug Administration, Rockville; Source Info: Dec1986, Vol. 76 Issue 12, p1422; Subject Term: INFLUENZA; Subject Term: CHICKENPOX; Subject Term: ASPIRIN; Subject Term: REYE'S syndrome; Subject Term: ANALGESICS; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: JUVENILE diseases; Subject Term: CHILD care; Subject Term: MEDICAL care; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Ehrenberg, Richard L.
AU - Singal, Mitchell
T1 - Investigation of Occupational Cancer Clusters: Theory and Practice.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/01//
VL - 77
IS - 1
M3 - Article
SP - 52
EP - 56
PB - American Public Health Association
SN - 00900036
AB - Abstract: Local and federal government agencies are often asked to investigate apparent clusters of cancer in communities or workplaces. Often these investigations cannot ulitize the methods that have been developed for evaluation of disease clusters because the clusters are too small, and the populations to he studied and the periods of time to be covered are determined in an a posteriori manner. Still, government investigators are called upon to render un official opinion of the apparent clusters. Application of a theoretical approach to cluster analysis must give way to a more pragmatic approach. A review of 61 investigations of apparent clusters conducted by the National Institute for Occupational Safety and Health (NIOSH) during the period 1978-84 showed that most of the clusters contained five or fewer cases and had no plausible occupational etiology. Despite the few clusters that were identified, these investigations generally provided a service to workers and employers who were concerned about occupational cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLUSTER analysis (Statistics)
KW - CANCER
KW - OCCUPATIONAL diseases
KW - TUMORS
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - PUBLIC health
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 4949059; Schulte, Paul A. 1 Ehrenberg, Richard L. 1 Singal, Mitchell 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati; Source Info: Jan1987, Vol. 77 Issue 1, p52; Subject Term: CLUSTER analysis (Statistics); Subject Term: CANCER; Subject Term: OCCUPATIONAL diseases; Subject Term: TUMORS; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schwartz, Robert A.
AU - Mathias, C. G. Toby
AU - Miller, Claramae H.
AU - Rojas-Corona, Rogelio
AU - Lambert, W. Clark
T1 - Granulomatous reaction to purple tattoo pigment.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1987/04//
VL - 16
IS - 4
M3 - Article
SP - 198
EP - 202
SN - 01051873
AB - An acute dermatitis overlying an immunologic granuloma was noted at the site of purple "dye" injection in a man with multiple multicolored tattoos. The skin reaction was observed 3 weeks after the injection, which proved to contain manganese, the usual metallic salt used for purple colored tattoos. Atomic absorption spectrometry showed a large amount of manganese in the biopsy specimen. Neither the dermatitis nor an immunologic granuloma could be reproduced with manganese salts or the alleged tattoo pigment. In addition, his peripheral blood lymphocytes were shown to he normal both in subset distribution and in their function, but these cells did not respond by blastogenesis to dilutions of the alleged pigment or to 2 manganese salts tested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - SKIN -- Inflammation
KW - TATTOOING
KW - GRANULOMA
KW - LYMPHOCYTES
KW - SKIN -- Biopsy
KW - Immunologic granuloma
KW - manganese.
KW - purple pigment
KW - tattoo
N1 - Accession Number: 12147182; Schwartz, Robert A. 1 Mathias, C. G. Toby 2,3 Miller, Claramae H. 4 Rojas-Corona, Rogelio 5 Lambert, W. Clark 1; Affiliation: 1: Dermatology, UMDNJ-New Jersey Medical School, Newark, NJ, USA. 2: Department of Dermatology, University of California Medical Center, San Francisco. 3: National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA. 4: Pathology, UC Davis School of Medicine, Davis, CA. 5: Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.; Source Info: Apr87, Vol. 16 Issue 4, p198; Subject Term: CONTACT dermatitis; Subject Term: SKIN -- Inflammation; Subject Term: TATTOOING; Subject Term: GRANULOMA; Subject Term: LYMPHOCYTES; Subject Term: SKIN -- Biopsy; Author-Supplied Keyword: Immunologic granuloma; Author-Supplied Keyword: manganese.; Author-Supplied Keyword: purple pigment; Author-Supplied Keyword: tattoo; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1600-0536.ep12147182
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MILLER, HENRY I.
T1 - The Case for Qualifying "Case by Case".
JO - Science
JF - Science
Y1 - 1987/04/10/
VL - 236
IS - 4798
M3 - Article
SP - 133
EP - 133
SN - 00368075
N1 - Accession Number: 87461349; MILLER, HENRY I. 1; Affiliation: 1: Special Assistant to the Commissioner, Food and Drug Administration, Rockville, MD 20857; Source Info: 4/10/1987, Vol. 236 Issue 4798, p133; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graves, Edmund J.
AU - Moien, Mary
T1 - Hospitalizations for AIDS, United States, 1984-85.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/06//
VL - 77
IS - 6
M3 - Article
SP - 729
EP - 730
PB - American Public Health Association
SN - 00900036
AB - Abstract: Data from the National Hospital Discharge Survey on hospitalizations for acquired immunodeficiency syndrome (AIDS) were analyzed for 1984-85. During 1984, an estimated 10,000 discharges from short-stay hospitals had a diagnosis of AIDS. In 1985, this figure more than doubled to 23,000. Ninety-seven percent of all AIDS discharges were male and 85 per ¢ were between the ages of 25 and 44[sub +] Hospitalizations For AIDS accounted for 510,000 days of hospital care and lusted an average of 15.6 days each (Am J Public Health 1987:77:729-730.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITALS -- Admission & discharge
KW - LENGTH of stay in hospitals
KW - AIDS (Disease)
KW - HOSPITAL records -- United States
KW - IMMUNOLOGICAL deficiency syndromes
KW - DIAGNOSIS
KW - HOSPITAL administration
KW - PUBLIC hospitals
KW - HEALTH services administration
KW - MEDICAL research
KW - UNITED States
N1 - Accession Number: 4951456; Graves, Edmund J. 1 Moien, Mary 1; Affiliation: 1: National Center for Health Statistics, US Department of Health and Human Services.; Source Info: Jun87, Vol. 77 Issue 6, p729; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: LENGTH of stay in hospitals; Subject Term: AIDS (Disease); Subject Term: HOSPITAL records -- United States; Subject Term: IMMUNOLOGICAL deficiency syndromes; Subject Term: DIAGNOSIS; Subject Term: HOSPITAL administration; Subject Term: PUBLIC hospitals; Subject Term: HEALTH services administration; Subject Term: MEDICAL research; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Richards, Thomas B.
AU - Gamble, John F.
AU - Castellan, Robert M.
AU - Mathias, C. G. Toby
T1 - Knuckle pads in live-chicken hangers.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1987/07//
VL - 17
IS - 1
M3 - Article
SP - 13
EP - 16
SN - 01051873
AB - A study of live-chicken hangers in a poultry processing plant demonstrated a high prevalence of callosities over the knuckels (knuckle pads) of both hands. Knuckle pads were observed in 56% (23/41) of live-chicken hanger, but in no (0/41) workers from other departments (p>0.001). The probable cause was the repeated striking and sliding of the knuckles against metal shackles in which live birds were being placed. Additional medical and ergonomic evaluation would be worthwhile to confirm the probable cause, to determine whether associated tissue disorders are present in the digits of chicken hanger who develop knuckle pads and to suggest preventive measures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHICKENS -- Diseases
KW - POULTRY -- Processing
KW - SKIN diseases
KW - TISSUES
KW - BIOENGINEERING
KW - BIRDS
KW - Callosities
KW - calluses
KW - knuckle pads
KW - occupation
KW - poultry processing
KW - skin disease ergonomics.
N1 - Accession Number: 12055900; Richards, Thomas B. 1,2 Gamble, John F. 1,2 Castellan, Robert M. 1,2 Mathias, C. G. Toby 1,2; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA; Source Info: Jul87, Vol. 17 Issue 1, p13; Subject Term: CHICKENS -- Diseases; Subject Term: POULTRY -- Processing; Subject Term: SKIN diseases; Subject Term: TISSUES; Subject Term: BIOENGINEERING; Subject Term: BIRDS; Author-Supplied Keyword: Callosities; Author-Supplied Keyword: calluses; Author-Supplied Keyword: knuckle pads; Author-Supplied Keyword: occupation; Author-Supplied Keyword: poultry processing; Author-Supplied Keyword: skin disease ergonomics.; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 112310 Chicken Egg Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1600-0536.ep12055900
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - FOX, CECIL H.
T1 - Public Health Service Revitalization.
JO - Science
JF - Science
Y1 - 1987/07/17/
VL - 237
IS - 4812
M3 - Article
SP - 235
EP - 235
SN - 00368075
N1 - Accession Number: 87436241; FOX, CECIL H. 1; Affiliation: 1: U.S. Public Health Service, Bethesda, MD 20205; Source Info: 7/17/1987, Vol. 237 Issue 4812, p235; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Muldoon, Joann T.
AU - Wintekmeyer, Laverne A.
AU - Eure, John A.
AU - Fuortes, Lawrence
AU - Merchant, James A.
AU - van Lier, Stephanie F.
AU - Richards, Thomas B.
T1 - Occupational Disease Surveillance Data Sources, 1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/08//
VL - 77
IS - 8
M3 - Article
SP - 1006
EP - 1008
PB - American Public Health Association
SN - 00900036
AB - Abstract: Health department epidemiologists in 50 states. New York City, and the District of Columbia were surveyed in 1985 about seven potential data sources for occupational disease surveillance. Reported sources of occupational disease data were: automated workers' compensation claims (63 per ¢ of the 52 respondents): provider reports (62 per ¢): death certificates with occupation or industry (60 per ¢): cancer registries with occupational histories (3.5 per ¢): birth certificates with parent's occupation (27 per ¢): non-cancer disease registries (13 per ¢): and hospital or insurance records (8 per ¢). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL diseases
KW - OCCUPATIONAL health services
KW - INDUSTRIAL hygiene
KW - WORK-related injuries
KW - WORKERS' compensation
KW - CANCER
KW - EPIDEMIOLOGY
KW - WORK environment
KW - HEALTH promotion
KW - UNITED States
N1 - Accession Number: 4949768; Muldoon, Joann T. 1 Wintekmeyer, Laverne A. 1 Eure, John A. 1 Fuortes, Lawrence 2 Merchant, James A. 2 van Lier, Stephanie F. 2 Richards, Thomas B. 3; Affiliation: 1: Division of Disease Preventium and Health Promotion, Iowa Department of Public Health, Lucas Building, Des Moines, IA. 2: Department of Preventive Medicine and Environmental Health, University of Iowa 3: Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health; Source Info: Aug1987, Vol. 77 Issue 8, p1006; Subject Term: OCCUPATIONAL diseases; Subject Term: OCCUPATIONAL health services; Subject Term: INDUSTRIAL hygiene; Subject Term: WORK-related injuries; Subject Term: WORKERS' compensation; Subject Term: CANCER; Subject Term: EPIDEMIOLOGY; Subject Term: WORK environment; Subject Term: HEALTH promotion; Subject Term: UNITED States; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - IWAMOTO, YUKIHIDE
AU - ROBEY, FRANK A.
AU - GRAF, JEANNETTE
AU - SASAKI, MAKOTO
AU - KLEINMAN, HYNDA K.
AU - YAMADA, YOSHIHIKO
AU - MARTIN, GEORGE R.
T1 - YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimenal Metastasis Formation.
JO - Science
JF - Science
Y1 - 1987/11/20/
VL - 238
IS - 4830
M3 - Article
SP - 1132
EP - 1134
SN - 00368075
AB - The invasion of tumor cells through basement membranes is a critical step in the formation of metastases. The binding of the malignant cells to laminin in the basement membranes allows their attachent and activates their invasiveness. Recently a synthetic nonapeptide from the B1 chain sequence oflaminin was identified as a major site for cell binding. A pentapeptide within the nonapeptide sequence was found to reduce the formation of lung colonies in mice injected with melanoma cells and also to inhibit the invasiveness of the cells in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 87477684; IWAMOTO, YUKIHIDE 1 ROBEY, FRANK A. 2 GRAF, JEANNETTE 1 SASAKI, MAKOTO 1 KLEINMAN, HYNDA K. 1 YAMADA, YOSHIHIKO 1 MARTIN, GEORGE R. 1; Affiliation: 1: Laboratory of Developmental Biology and Anomalies, National Institute of Drug Research, National Institutes of Health, Bethesda, MD 20892 2: Bureau of Biologics, Food and Drug Administration, Bethesda, MD 20892; Source Info: 11/20/1987, Vol. 238 Issue 4830, p1132; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Harold
AU - Honchar, Patricia A.
AU - Suarez, Lucina
T1 - Fatal Occupational Injuries of Women, Texas 1975-84.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1987/12//
VL - 77
IS - 12
M3 - Article
SP - 1524
EP - 1527
PB - American Public Health Association
SN - 00900036
AB - Abstract: A review of Texas death certificates for 1975-84 identified 348 cases of fatal occupational injuries of civilian females. Homicides accounted for 53 per ¢ and motor vehicle-related injuries accounted for 26 per ¢ of the deaths. Injuries from firearms caused 70 per ¢ of the homicides, One hundred thirty-three deaths occurred to women employed in the retail trade industry: of these, 77 per ¢ resulted from homicide. Women workers in gasoline service stations, food-bakery-and-dairy stores, and eating-and-drinking places had especially high risks of homicide. Texas female heavy-truck drivers had the highest fatal-injury rate, with motor-vehicle-related injuries causing 89 per ¢ of their deaths. These results indicate that effective strategies to prevent fatal occupational injuries of Texas women will need to address the problems of workplace violence and the hazards posed by motor vehicles. {Am J Public Health 1987: 77:1524-1527.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEATH -- Causes
KW - STATISTICS
KW - WOMEN employees
KW - WOMEN
KW - WOUNDS & injuries
KW - WORK-related injuries
KW - INDUSTRIAL safety
KW - OCCUPATIONAL diseases
KW - MORTALITY -- Statistics
KW - DEATH (Biology)
KW - TEXAS
N1 - Accession Number: 4949575; Davis, Harold 1 Honchar, Patricia A. 2 Suarez, Lucina 3; Affiliation: 1: Office of Epidemiology and Biostatistics, Food and Drug Administration, 5600 Fishers Lane, HFN-733, Rockville, MD 20857 2: National Institute for Occupational Safety and Health, CDC 3: Bureau of Epidemiology, Texas Department of Health, Austin; Source Info: Dec1987, Vol. 77 Issue 12, p1524; Subject Term: DEATH -- Causes; Subject Term: STATISTICS; Subject Term: WOMEN employees; Subject Term: WOMEN; Subject Term: WOUNDS & injuries; Subject Term: WORK-related injuries; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL diseases; Subject Term: MORTALITY -- Statistics; Subject Term: DEATH (Biology); Subject Term: TEXAS; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Lois K.
AU - Bailit, Howard L.
AU - Barmes, David E.
T1 - INTERNATIONAL COLLABORATIVE STUDY OF ORAL HEALTH OUTCOMES.
JO - International Sociology
JF - International Sociology
Y1 - 1987/12//
VL - 2
IS - 4
M3 - Article
SP - 419
EP - 426
SN - 02685809
AB - Building upon the completed WHO International Collaborative Study of Dental Manpower Systems in Relation to Oral Health Status (ICS-I), a project which extended from 1972-1983 and was operational in ten industrialised countries, the new five-year cross-national study of oral health outcomes (ICS-Il) is described. The new project includes some of the industrialised countries having participated in ICS-I plus some new ones, as well as a limited number of middle-income developing countries (Egypt, India and Uruguay).Information on the relative contribution of environmental, personal life-style and the care systems will be analysed in relation to oral health status and the costs of care. Results are expected to yield refinements in strategies for improving oral health. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Sociology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - DENTISTRY
KW - ORAL hygiene
KW - INTERNATIONAL cooperation
KW - DEVELOPING countries
N1 - Accession Number: 11498808; Cohen, Lois K. 1 Bailit, Howard L. 2 Barmes, David E. 3; Affiliation: 1: Assistant Director for International Health and Chief Planning, Evaluation and Communications, National Institute of Dental Research, National Institute of Health, U.S. Public Health Service 2: Vice-President for Health Research and Policy, Aetna Life and Casualty, Hartford, Connecticut, USA 3: Oral Health, World Health Organization, 1211 Geneva 27, Switzerland; Source Info: Dec87, Vol. 2 Issue 4, p419; Subject Term: DENTAL care; Subject Term: DENTISTRY; Subject Term: ORAL hygiene; Subject Term: INTERNATIONAL cooperation; Subject Term: DEVELOPING countries; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kinney, Janet S.
AU - Gross, Thomas P.
AU - Porter, Craig C.
AU - Rogers, Martha F.
AU - Schonberger, Lawrence B.
AU - Hurwitz, Eugene S.
T1 - Hemolytic-Uremic Syndrome: A Population-based Study in Washington, DC and Baltimore, Maryland.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/01//
VL - 78
IS - 1
M3 - Article
SP - 64
EP - 65
PB - American Public Health Association
SN - 00900036
AB - Abstract: A population-based study of hemolytic-uremic syndrome (HUS) revealed that 20 child residents of Washington, DC and Baltimore, Maryland were hospitalized with HUS from January 1979 through September 1983. The number of cases peaked during the summer and fall; none occurred during the winter. Incidence of hospitalized cases was higher in Whites and girls than in Blacks or boys, and the average annual incidence was 1.08 cases/100,000 children < 5 year old. This study demonstrates that HUS is not unique to the West Coast, as previously suggested. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOLYTIC-uremic syndrome
KW - JUVENILE diseases
KW - HOSPITAL care
KW - AFRICAN Americans
KW - WHITE children
KW - DISEASES
KW - POPULATION research
KW - WASHINGTON (D.C.)
KW - BALTIMORE (Md.)
KW - MARYLAND
N1 - Accession Number: 4686240; Kinney, Janet S. 1 Gross, Thomas P. 2 Porter, Craig C. 1 Rogers, Martha F. 3 Schonberger, Lawrence B. 3 Hurwitz, Eugene S. 3; Affiliation: 1: Department of Pediatrics, Johns Hopkins School of Medicine. 2: Division of Epidemiology and Surveillance, Food and Drug Administration. 3: Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control.; Source Info: Jan1988, Vol. 78 Issue 1, p64; Subject Term: HEMOLYTIC-uremic syndrome; Subject Term: JUVENILE diseases; Subject Term: HOSPITAL care; Subject Term: AFRICAN Americans; Subject Term: WHITE children; Subject Term: DISEASES; Subject Term: POPULATION research; Subject Term: WASHINGTON (D.C.); Subject Term: BALTIMORE (Md.); Subject Term: MARYLAND; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Becker, Burton E.
AU - Karp, Cheryl L.
AU - Becker, William
AU - Berg, Laurence
T1 - Personality differences and stressful life events. Differences between treated periodontal patients with and without maintenance.
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
Y1 - 1988/01//
VL - 15
IS - 1
M3 - Article
SP - 49
EP - 52
SN - 03036979
AB - The purpose of this study was to determine whether personality differences exist between patients who have had periodontal therapy and continued in maintenance compared with those who have had periodontal therapy and no maintenance. In addition, an attempt was made to determine whether there were differences in reactions to stressful life events among the 2 groups of patients. Patients were evaluated for personality differences using the adjective check list. A background questionnaire was used to gather personal data and information pertinent to stressful life events. The maintained group had a more positive image of themselves. They had higher achievement, endurance and affiliation scores than did the patients without maintenance. The unmaintained group had higher negative aggression scores, a higher incidence of stressful life events, and less stable personal relationships in their lives. (English) [ABSTRACT FROM AUTHOR]
AB - Es wurde beabsichtigt durch diese Studie festzustellen, ob persönlichkeitsbedingte Unterschiede zwischen parodontal behandelten Patienten mit und ohne Nachsorge existieren. Weiterhin wurde versucht herauszustellen, ob zwischen den beiden Patientengruppen in ihrer Reaktion auf stressgeladene Lebensereignisse Unterschiede bestünden. Persönlichkeitsunterschiede zwischen Patienten wurden mit der "Adjective Check List' (Checkliste über Eigenschaften) bestimmt. Mit einem Fragebogen über Hintergrundsfaktoren wurden persönliche Daten und Informationen über stressbedingte Ereignisse im Leben der Patienten registriert. Die Probandengruppe mit Nachsorge verfügte über eine bedeutend positivere Selbstauffassung. Die Beurteilungseinheiten für Tatkraft, Ausdauer und Anpassung waren höher als bei Patienten, die keine Nachsorge in Anspruch nahmen. Bei der Gruppe ohne Nachsorge wurden höhere Beurteilungseinheiten für negative Aggression, häufigeres Vorkommen stressbetonter Ereignisse in ihrem Leben und weniger stabile persönliche Bindungen registriert. (German) [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Periodontology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODONTAL disease
KW - DENTAL therapeutics
KW - PERSONALITY
KW - PATIENTS
KW - PERIODONTICS
KW - DENTISTRY
KW - Personality differences
KW - stressful life events.
N1 - Accession Number: 13476952; Becker, Burton E. 1 Karp, Cheryl L. 2 Becker, William 1 Berg, Laurence 3; Affiliation: 1: Department of Periodontics, University of Southern California School of Dentistry, USA. 2: Tucson Medical Center and Palo Verde Hospital, USA. 3: Office of Research and Development, Indian Health Service, Tucson, USA.; Source Info: Jan1988, Vol. 15 Issue 1, p49; Subject Term: PERIODONTAL disease; Subject Term: DENTAL therapeutics; Subject Term: PERSONALITY; Subject Term: PATIENTS; Subject Term: PERIODONTICS; Subject Term: DENTISTRY; Author-Supplied Keyword: Personality differences; Author-Supplied Keyword: stressful life events.; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1600-051X.ep13476952
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen, James R.
AU - Curran, James W.
T1 - Prevention of AIDS and HIV Infection: Needs and Priorities for Epidemiologic Research.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/04//
VL - 78
IS - 4
M3 - Article
SP - 381
EP - 386
PB - American Public Health Association
SN - 00900036
AB - By the end of 1987, almost 50,000 cases of acquired immunodeficiency syndrome (AIDS) will have been reported in the United States. Although the primary epidemiology of the disease has been described, much work remains to be done to complete our understanding of the dynamics of transmission and infection with the causative virus, human immunodeficiency virus (HIV). At the state and local level, the highest priorities for epidemiologic research are to understand better the precise populations at risk of prevalent and incident HIV infection, and to use this information to direct and monitor specific prevention programs that are likely to be effective for the populations at risk. These parallel efforts—sophisticated investigative epidemiologic research and applied epidemiologic and serosurveillance studies—must be expanded rapidly and continued for the forseeable future if we are to accomplish the goal of preventing further spread of HIV. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - COMMUNICABLE diseases
KW - EPIDEMIOLOGY
KW - HIV infections
KW - LENTIVIRUS diseases
KW - COMMUNICABLE diseases -- Transmission
KW - HIV (Viruses)
KW - HTLV (Viruses)
KW - UNITED States
N1 - Accession Number: 4687154; Allen, James R. 1 Curran, James W. 2; Affiliation: 1: Assistant Director for Medial Science, AIDS Program, Building 6 Room 177 (G22), Center for Infectious Diseases, Centers for Disease Control, US Public Health Service, Atlanta, GA 3033 2: Director of the AIDS Program, CID/CDC Atlanta; Source Info: Apr88, Vol. 78 Issue 4, p381; Subject Term: AIDS (Disease); Subject Term: COMMUNICABLE diseases; Subject Term: EPIDEMIOLOGY; Subject Term: HIV infections; Subject Term: LENTIVIRUS diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: HIV (Viruses); Subject Term: HTLV (Viruses); Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Placek, Paul J.
AU - Taffel, Selma M.
T1 - Vaginal Birth after Cesarean (VBAC) in the 1980s.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 512
EP - 515
PB - American Public Health Association
SN - 00900036
AB - The incidence of vaginal birth after cesarean (VBAC) and characteristics of VBAC births are investigated using 1980-85 National Hospital Discharge Survey Data collected by the National Center for Health Statistics. Only 3.4 per cent of mothers with previous cesarean delivery had VBAC in their subsequent 1980 delivery; this increased to 6.6 per cent in 1985. Because VBAC is a relatively infrequent event, 1980-85 data were combined and indicate that in this period 4.9 per cent of mothers with previous cesarean had a vaginal birth in their subsequent delivery. Combined 1980-85 VBAC rates are under 10 per cent for all age, race, marital status, region, hospital size, hospital ownership, and expected source of payment groups. Between 1980 and 1985, over 1.4 million repeat cesareans were performed for mothers having a live birth. Evidence suggests that potentially over 500,000 of these repeat cesareans could have been VBACs (over and above the 74,000 VBACs which occurred). VBAC mothers' mean length of hospital stay is 3.2 days, which compares closely with 3.0 days for other vaginal deliveries, but both contrast sharply with 5.6 days for repeat cesareans and 6.0 days for primary cesareans. Except for the uterine scar from the previous cesarean, VBAC mothers appear to have about the same history and frequency of complications as mothers with other vaginal deliveries. If the 500,000 repeat cesareans had been VBACs, surgical fees and costs for 1.2 million days of hospital stay would have been averted over the 1980-85 period. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VAGINAL birth after cesarean
KW - CESAREAN section -- Prevention
KW - DELIVERY (Obstetrics)
KW - CHILDBIRTH
KW - MEDICAL care costs
KW - LENGTH of stay in hospitals
KW - MEDICAL statistics
KW - UNITED States
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4686890; Placek, Paul J. 1 Taffel, Selma M. 1; Affiliation: 1: National Center for health Statistics, US Department of Health and Human Services.; Source Info: May88, Vol. 78 Issue 5, p512; Subject Term: VAGINAL birth after cesarean; Subject Term: CESAREAN section -- Prevention; Subject Term: DELIVERY (Obstetrics); Subject Term: CHILDBIRTH; Subject Term: MEDICAL care costs; Subject Term: LENGTH of stay in hospitals; Subject Term: MEDICAL statistics; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Placek, Paul J.
AU - Taffel, Selma M.
AU - Moien, Mary
T1 - 1986 C-Sections Rise: VBACs Inch Upward.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/05//
VL - 78
IS - 5
M3 - Article
SP - 562
EP - 563
PB - American Public Health Association
SN - 00900036
AB - The article focuses on the statistics of cesarean delivery in the U.S. in 1965 to 1986. During 1965, the rate of cesarean delivery was 4.5%, 22.7% in 1985, and has finally reached 24.1% in 1986. Such data is fairly uniform for women of all ages and marital statuses, and has been observed in hospitals of all sizes and types of ownership. The National Center for Health Statistics conducted the National Hospital Discharge Survey to monitor the annual trends of cesareans. Information came from about 200,000 medical records for inpatient discharges from a representative national sample of over 400 non-federal general and special short-stay hospitals. It also showed that almost one-fifth of teenage deliveries were cesareans.
KW - CESAREAN section
KW - DELIVERY (Obstetrics)
KW - OBSTETRICS -- Surgery
KW - MARITAL status
KW - MEDICAL records
KW - PUBLIC hospitals
KW - MEDICAL statistics
KW - UNITED States
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 4687133; Placek, Paul J. 1 Taffel, Selma M. 1 Moien, Mary 1; Affiliation: 1: National Center for Health Statistics, US Department of Health and Human Services.; Source Info: May88, Vol. 78 Issue 5, p562; Subject Term: CESAREAN section; Subject Term: DELIVERY (Obstetrics); Subject Term: OBSTETRICS -- Surgery; Subject Term: MARITAL status; Subject Term: MEDICAL records; Subject Term: PUBLIC hospitals; Subject Term: MEDICAL statistics; Subject Term: UNITED States; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wells, Victoria E.
AU - Halperin, William
AU - Thun, Michael
T1 - The Estimated Predictive Value of Screening for Illicit Drugs in the Workplace.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/07//
VL - 78
IS - 7
M3 - Article
SP - 817
EP - 819
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper estimates the predictive values of screening tests for six illicit drugs of common concern in the workplace (amphetamines, barbiturates, cocaine, hallucinogens, marijuana, and opiates) using published information on test sensitivity and specificity and survey data on prevalence. Estimated predictive values (negative) were generally high, whereas the estimated predictive value of a positive test ranged from 1 per ¢ for amphetamines to 100 per ¢ for hallucinogens and was only 38 per ¢ for marijuana, the most prevalent drug. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS of abuse
KW - DRUGS
KW - DRUG use testing
KW - EXAMINATIONS
KW - MEDICAL screening
KW - DRUG abuse
KW - AMPHETAMINES
KW - BARBITURATES
KW - HALLUCINOGENIC drugs
N1 - Accession Number: 4691682; Wells, Victoria E. 1 Halperin, William 1 Thun, Michael 1; Affiliation: 1: National Institute of Occupational Safety and Health; Source Info: Jul1988, Vol. 78 Issue 7, p817; Subject Term: DRUGS of abuse; Subject Term: DRUGS; Subject Term: DRUG use testing; Subject Term: EXAMINATIONS; Subject Term: MEDICAL screening; Subject Term: DRUG abuse; Subject Term: AMPHETAMINES; Subject Term: BARBITURATES; Subject Term: HALLUCINOGENIC drugs; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patriarca, Peter A.
AU - Biellik, Robin J.
AU - Sanden, Gary
AU - Burstyn, Don G.
AU - Mitchell, Paul D.
AU - Silverman, Paul R.
AU - Davis, Jeffrey P.
AU - Manclark, Charles R.
T1 - Sensitivity and Specificity of Clinical Case Definitions for Pertussis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/07//
VL - 78
IS - 7
M3 - Article
SP - 833
EP - 836
PB - American Public Health Association
SN - 00900036
AB - Abstract: We evaluated the diagnostic performance of 15 clinical case definitions for pertussis in 233 patients who developed acute respiratory illness during community outbreaks in Wisconsin and Delaware. Using results from culture (Regan-Lowe media) and serology (Ig-class-specific ELISA) as diagnostic standards, cough for >/= 14 days was both sensitive (84 per ¢-92 per ¢) and specific (63 percent-90 per ¢) m identifying patients with pertussis. This definition may be useful in monitoring pertussis outbreaks and for investigating contacts of culture-positive cases. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - WHOOPING cough
KW - EPIDEMICS
KW - SEROLOGY
KW - PATIENTS
KW - DISEASES
KW - RESPIRATORY organs
KW - CARDIOPULMONARY system
KW - DIAGNOSTIC microbiology
N1 - Accession Number: 4692589; Patriarca, Peter A. 1 Biellik, Robin J. 1 Sanden, Gary 2 Burstyn, Don G. 3 Mitchell, Paul D. 4 Silverman, Paul R. 5 Davis, Jeffrey P. 6 Manclark, Charles R. 3; Affiliation: 1: Division of Immunization, Centers for Disease Control 2: Division of Bacterial Disease, CDC 3: Office of Biologics Research and Review, Food and Drug Administration 4: Marshfield, Wisconsin Clinic 5: Delaware Department of Health 6: Wisconsin Division of Health; Source Info: Jul1988, Vol. 78 Issue 7, p833; Subject Term: RESPIRATORY diseases; Subject Term: WHOOPING cough; Subject Term: EPIDEMICS; Subject Term: SEROLOGY; Subject Term: PATIENTS; Subject Term: DISEASES; Subject Term: RESPIRATORY organs; Subject Term: CARDIOPULMONARY system; Subject Term: DIAGNOSTIC microbiology; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zeeman, Maurice
T1 - CARSON CONTROVERSY CONTINUES.
JO - BioScience
JF - BioScience
Y1 - 1988/07//Jul/Aug88
VL - 38
IS - 7
M3 - Book Review
SP - 509
EP - 510
SN - 00063568
AB - Reviews the book "Silent Spring Revisited," edited by G. J. Marco, R. M. Hollingworth, and W. Durham.
KW - PESTICIDES & wildlife
KW - NONFICTION
KW - SILENT Spring Revisited (Book)
N1 - Accession Number: 10112070; Zeeman, Maurice 1; Affiliation: 1: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Jul/Aug88, Vol. 38 Issue 7, p509; Subject Term: PESTICIDES & wildlife; Subject Term: NONFICTION; Reviews & Products: SILENT Spring Revisited (Book); Number of Pages: 2p; Document Type: Book Review; Full Text Word Count: 730
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mathias, C. G. Tory
T1 - Allergic contact dermatitis from triglycidyl isocyanurate in polyester paint pigments.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1988/07//
VL - 19
IS - 1
M3 - Article
SP - 67
EP - 68
SN - 01051873
AB - This article presents information on a case study related to allergic contact dermatitis from triglycidyl isocyanurate in polyester paint pigments. A 25-year-old Caucasian male began work for a manufacturer of outdoor light fixtures. All fixtures assembled were sprayed with a protective paint. Painters applied the pigments with spray guns. The patient developed severe dermatitis of the ears, forehead, perioral skin and cheeks near the eyes, where pigment concentrated around the margins of his half-face cartridge respirator. The pigments contained approximately 5% triglycidyl isocyanurate, described by the manufacturer as a polyfunctional epoxy resin used to cross-link the polyester pigments upon heat activation.
KW - CONTACT dermatitis
KW - DELAYED hypersensitivity
KW - SKIN -- Inflammation
KW - PAINT
KW - PIGMENTS
KW - OCCUPATIONAL diseases
N1 - Accession Number: 12045993; Mathias, C. G. Tory 1,2; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cinicinnati, Ohio 45226. 2: Department of Occupational and Environmental Medicine, University of Cincinnati Medical Center, Cineinnati, Ohio 45267, USA.; Source Info: Jul88, Vol. 19 Issue 1, p67; Subject Term: CONTACT dermatitis; Subject Term: DELAYED hypersensitivity; Subject Term: SKIN -- Inflammation; Subject Term: PAINT; Subject Term: PIGMENTS; Subject Term: OCCUPATIONAL diseases; NAICS/Industry Codes: 444120 Paint and Wallpaper Stores; NAICS/Industry Codes: 416340 Paint, glass and wallpaper merchant wholesalers; NAICS/Industry Codes: 325510 Paint and Coating Manufacturing; NAICS/Industry Codes: 424950 Paint, Varnish, and Supplies Merchant Wholesalers; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0536.ep12045993
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stout-Wiegand, Nancy
T1 - Fatal Occupational Injuries in US Industries, 1984: Comparison of Two National Surveillance Systems.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/09//
VL - 78
IS - 9
M3 - Article
SP - 1215
EP - 1217
PB - American Public Health Association
SN - 00900036
AB - This paper compares the results of analyses of 1984 fatalities as identified in the National Institute for Occupational Safety and Health (NIOSH) National Traumatic Occupational Fatality (NTOF) data base with those of the Bureau of Labor Statistics' Annual Survey of Occupational Injuries and Illnesses (AS) for 1984. The fatality rates for industries were similar in both analyses; however, differences in number of injuries suggest underrepresentation in the AS of fatal injuries in several, high-risk industries. Differences and similarities in methods and results between the two national surveillance systems are described and their application to research and injury prevention are discussed. (Am J Public Health 1988; 78:1215-1217.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - WOUNDS & injuries
KW - ACCIDENTS
KW - INDUSTRIES
KW - SURVEYS
KW - RESEARCH
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 4686149; Stout-Wiegand, Nancy 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505; Source Info: Sep88, Vol. 78 Issue 9, p1215; Subject Term: WORK-related injuries; Subject Term: WOUNDS & injuries; Subject Term: ACCIDENTS; Subject Term: INDUSTRIES; Subject Term: SURVEYS; Subject Term: RESEARCH; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seligman, Paul J.
AU - Sieber Jr., William Karl
AU - Pedersen, David H.
AU - Sundin, David S.
AU - Frazier, Todd M.
T1 - Compliance with OSHA Record-keeping Requirements.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/09//
VL - 78
IS - 9
M3 - Article
SP - 1218
EP - 1219
PB - American Public Health Association
SN - 00900036
AB - The Occupational Safety and Health Act of 1970 requires employers to maintain records of workplace injuries and illnesses. To assess compliance with the law, data from the National Occupational Exposure Survey (NOES) were examined. Of the 4,185 companies with 11 or more employees, 75 per cent maintained OSHA Form 200 designed for recording illnesses and injuries. The number of employees and the presence of a union were positive determinants in the record maintenance. Of companies with 500 or more employees, 95 per cent kept records compared with 60 per cent of companies with between 11 and 99 employees. (Am J Public Health 1988, 78:1218-1219.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - WOUNDS & injuries
KW - ACCIDENTS
KW - RECORDS management
KW - DISEASES
KW - SURVEYS
KW - EMPLOYEES
KW - LABOR unions
KW - UNITED States. Occupational Safety & Health Administration
N1 - Accession Number: 4686163; Seligman, Paul J. 1 Sieber Jr., William Karl 1 Pedersen, David H. 1 Sundin, David S. 1 Frazier, Todd M. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Sep88, Vol. 78 Issue 9, p1218; Subject Term: WORK-related injuries; Subject Term: WOUNDS & injuries; Subject Term: ACCIDENTS; Subject Term: RECORDS management; Subject Term: DISEASES; Subject Term: SURVEYS; Subject Term: EMPLOYEES; Subject Term: LABOR unions; Company/Entity: UNITED States. Occupational Safety & Health Administration; NAICS/Industry Codes: 561490 Other business support services; NAICS/Industry Codes: 813930 Labor Unions and Similar Labor Organizations; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Platt, Mark W.
AU - Rottem, Shlomo
AU - Milner, Yoram
AU - Barile, Michael F.
AU - Peterkofsky, Alan
AU - Reizer, Jonathan
T1 - Protein phosphorylation in Mycoplasma gallisepticum.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1988/09//9/1/88
VL - 176
IS - 1
M3 - Article
SP - 62
EP - 67
PB - Wiley-Blackwell
SN - 00142956
AB - Incubation of the soluble fraction derived from Mycoplasma gallisepticum cells with [γ-32P]ATP results in the phosphorylation of several endogenous proteins. One protein with an apparent molecular mass of 55 kDa was the acceptor of more than 95% of the radioactive phosphate. This protein was also found to be radiolabeled in intact cells grown in the presence of [32P]orthophosphate. Acid hydrolysis of the phosphorylated 55-kDa protein followed by two-dimensional electrophoresis revealed that the 32P-labeled material co-migrated with phosphoserine. The in vitro phosphorylation of the 55-kDa protein has an optimum pH of 5.5-6.0 and is not affected by various metabolites of glycolysis, by cAMP or by calmodulin with or without Ca2+. The phosphorylation is dependent upon divalent cations, a dependency that is best fulfilled by the simultaneous addition of Ca2+ and Zn2+ that act in a specific and cooperative manner. Of a variety of possible exogenous protein acceptors tested, the endogenous protein kinase was capable to phosphorylate only phosvitin. The phosphorylation of the 55-kDa protein is reversible through the activity of a phosphoprotein phosphatase present in the soluble fraction of M. gallisepticum. The phosphoprotein phosphatase has an optimum pH of 7.5 -8.0, is inhibited by NaF and stimulated to a large extent by inorganic phosphate and arsenate and to a lesser extent by pyrophosphate ATP and ADP. The possible association of the reversible protein phosphorylation to cell shape and gliding motility of M. gallisepticum are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinases
KW - PHOSPHORYLATION
KW - HYDROGEN-ion concentration
KW - CELL morphology
KW - PHASE partition
KW - ELECTROPHORESIS
KW - CHEMICAL reactions
N1 - Accession Number: 15818680; Platt, Mark W. 1 Rottem, Shlomo 1 Milner, Yoram 2 Barile, Michael F. 3 Peterkofsky, Alan 4 Reizer, Jonathan 4; Affiliation: 1: Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School, Jerusalem. 2: Department of Biological Chemistry, The Hebrew University, Jerusalem. 3: Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland. 4: National Heart, Lung, and Blood Institute, Bethesda, Maryland; Source Info: 9/1/88, Vol. 176 Issue 1, p62; Subject Term: PROTEIN kinases; Subject Term: PHOSPHORYLATION; Subject Term: HYDROGEN-ion concentration; Subject Term: CELL morphology; Subject Term: PHASE partition; Subject Term: ELECTROPHORESIS; Subject Term: CHEMICAL reactions; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horohov, D. W.
AU - Stocks, N. I.
AU - Siegel, J. P.
T1 - Limiting-dilution analysis of human CTL differentiation. Requirement for a lymphokine-mediated differentiation signal.
JO - Immunology
JF - Immunology
Y1 - 1988/09//
VL - 65
IS - 1
M3 - Article
SP - 119
EP - 124
PB - Wiley-Blackwell
SN - 00192805
AB - The induction of human influenza virus-specific memory cytotoxic T lymphocytes (CTL) from CTL precursors (CTLp) was investigated using limiting-dilution cultures and cell lines. Differentiation of maximal numbers of CTLp in limiting-dilution cultures required at least three signals: antigen stimulation, interleukin-2 (IL-2), and a differentiation factor distinct from IL-2. Antigen-specific CTLp proliferated in response to antigen stimulation and recombinant DNA-derived IL-2, but often failed to acquire cytolytic activity unless conditioned medium (CM) from mitogen-stimulated peripheral blood mononuclear cell (PBMC) cultures was added to the cultures. Temporal analysis of the requirement for CM indicated that it was providing a late signal for CTLp differentiation. This analysis was confirmed by developing CTLp cell lines, which were found to proliferate in response to IL-2 and antigen but not to exhibit influenza virus-specific cytotoxicity until CM was added. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - T cells
KW - ANTINEOPLASTIC antibiotics
KW - CELL proliferation
KW - MITOGENS
KW - PROTEIN precursors
N1 - Accession Number: 14004475; Horohov, D. W. 1 Stocks, N. I. 2 Siegel, J. P. 2; Affiliation: 1: Dept. Veterinary Microbiology and Parasitology, Louisianna State University School of Veterinary Medicine, Baton Rouge, Louisianna, U.S.A. 2: Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Sep88, Vol. 65 Issue 1, p119; Subject Term: INFLUENZA; Subject Term: T cells; Subject Term: ANTINEOPLASTIC antibiotics; Subject Term: CELL proliferation; Subject Term: MITOGENS; Subject Term: PROTEIN precursors; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klain, Matthew
AU - Coulehan, John L.
AU - Arena, Vincent C.
AU - Janett, Robert
T1 - More Frequent Diagnosis of Acute Myocardial Infarction among Navajo Indians.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/10//
VL - 78
IS - 10
M3 - Article
SP - 1351
EP - 1352
PB - American Public Health Association
SN - 00900036
AB - Abstract: In an earlier study, we failed to confirm a clinical impression that the incidence of acute myocardial infarction (AMI) was increasing in Navajo men. Extending our data collection an additional three years, through 1986, we observed that the attack rate in men more than doubled and there was a gradual increase among women. Most Navajos who sustain AMI are hypertensive (51 per ¢), diabetic (50 per ¢) or both (31 per ¢), but few smoke cigarettes. (Am J Public Health 1988; 78:1351-1352.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOCARDIAL infarction
KW - NAVAJO (North American people)
KW - CORONARY heart disease
KW - HEART diseases
KW - HYPERTENSION
KW - HEART diseases -- Diagnosis
KW - DIABETES
KW - SMOKING
KW - PUBLIC health
N1 - Accession Number: 4692035; Klain, Matthew 1 Coulehan, John L. 1 Arena, Vincent C. 1 Janett, Robert 2; Affiliation: 1: Associate Professor, Department of Community Medicine, University of Pittsburgh, M200 Scaife Hall, Pittsburgh, PA 15261 2: US Public Health Service Hospital, Tuba City, Arizona; Source Info: Oct88, Vol. 78 Issue 10, p1351; Subject Term: MYOCARDIAL infarction; Subject Term: NAVAJO (North American people); Subject Term: CORONARY heart disease; Subject Term: HEART diseases; Subject Term: HYPERTENSION; Subject Term: HEART diseases -- Diagnosis; Subject Term: DIABETES; Subject Term: SMOKING; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hemminki, Elina
AU - Kennedy, Dianne L.
AU - Baum, Carlene
AU - McKinlay, Sonja M.
T1 - Prescribing of Noncontraceptive Estrogens and Progestins in the United States, 1974-86.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/11//
VL - 78
IS - 11
M3 - Article
SP - 1479
PB - American Public Health Association
SN - 00900036
AB - Abstract: This paper describes changes in the prescribing of noncontraceptive estrogens and progestins, using data from pharmaceutical marketing surveys. The number of estrogen prescriptions decreased from 1975 to 1980, and then increased through 1986. Progestin use has increased since 1982; concomitant use of estrogens and progestins increased over time and was common in 1986. The trends suggest that the use of estrogens, particularly the combined use of estrogens and progestins, will continue to increase. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX hormones
KW - PROGESTATIONAL hormones
KW - ESTROGEN
KW - MEDICINE -- Formulae, receipts, prescriptions
KW - CONTRACEPTIVES
KW - PHARMACEUTICAL industry
KW - PROGESTERONE
KW - SYNTHETIC drugs
KW - UNITED States
N1 - Accession Number: 4690877; Hemminki, Elina 1 Kennedy, Dianne L. 2 Baum, Carlene 2 McKinlay, Sonja M. 3; Affiliation: 1: Department of Public Health. University of Helsinki. Haartmanink 3, 00290 Helsinki, Finland 2: Division of Epidemiology and Surveillance. Food and Drug Administration. 5600 Fishers Lane. Rockville. MD 3: Principal Research Scientist , Cambridge Research Center. American Institutes for Research; Source Info: Nov88, Vol. 78 Issue 11, p1479; Subject Term: SEX hormones; Subject Term: PROGESTATIONAL hormones; Subject Term: ESTROGEN; Subject Term: MEDICINE -- Formulae, receipts, prescriptions; Subject Term: CONTRACEPTIVES; Subject Term: PHARMACEUTICAL industry; Subject Term: PROGESTERONE; Subject Term: SYNTHETIC drugs; Subject Term: UNITED States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Harold
T1 - The Accuracy of Industry Data from Death Certificates for Workplace Homicide Victims.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/12//
VL - 78
IS - 12
M3 - Article
SP - 1579
EP - 1581
PB - American Public Health Association
SN - 00900036
AB - Abstract: This study compared death certificate data on usual industry for workplace homicide victims in five urban Texas counties, with medical examiners' data on the industries where victims were working when injured. The overall positive predictive value of the death certificate data was 72 per ¢. Death certificate data on usual industry underestimated the number of victims working in high-risk industries when injured, partly because of victims whose usual industry was recorded as student, housewife, or military personnel. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - INDUSTRIAL safety education
KW - INDUSTRIAL laws & legislation
KW - WORK environment
KW - INDUSTRIAL management
KW - INDUSTRIAL safety
KW - RISK management in business
KW - OCCUPATIONAL hazards
KW - DEATH certificates
KW - TEXAS
KW - UNITED States
N1 - Accession Number: 4686239; Davis, Harold 1; Affiliation: 1: Office of Epidemiology and Biostatistics, HFD-733, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Dec1988, Vol. 78 Issue 12, p1579; Subject Term: WORK-related injuries; Subject Term: INDUSTRIAL safety education; Subject Term: INDUSTRIAL laws & legislation; Subject Term: WORK environment; Subject Term: INDUSTRIAL management; Subject Term: INDUSTRIAL safety; Subject Term: RISK management in business; Subject Term: OCCUPATIONAL hazards; Subject Term: DEATH certificates; Subject Term: TEXAS; Subject Term: UNITED States; NAICS/Industry Codes: 611690 All other schools and instruction; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, Roberta L.
AU - Dexter, Don
T1 - Smokeless Tobacco Use and Attitudes toward Smokeless Tobacco among Native Americans and Other Adolescents in the Northwest.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1988/12//
VL - 78
IS - 12
M3 - Article
SP - 1586
EP - 1588
PB - American Public Health Association
SN - 00900036
AB - Abstract: A survey of 1,180 sixth, ninth, and eleventh graders in three school districts in the State of Washington found that 34 per ¢ of male Native Americans, 24 per ¢ of female Native Americans, 20 per ¢ of male non-natives and 4 per ¢ of female non-natives are current users of smokeless tobacco products. In all areas and groups, the best predictor of whether an adolescent is a user is the use pattern of friends. INSET: NIH Consensus Statement on Perioperative Red Cell Transfusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKELESS tobacco
KW - NATIVE Americans
KW - SURVEYS
KW - TEENAGERS
KW - TOBACCO industry
KW - SMOKELESS tobacco industry
KW - SCHOOL districts
KW - WOMEN consumers
KW - UNITED States
N1 - Accession Number: 4686364; Hall, Roberta L. 1 Dexter, Don 2; Affiliation: 1: Professor, Department of Anthropology, Oregon State University, Corvallis, OR 97331 2: Public Health Service Indian Health Center, Warm Springs, OR 977761; Source Info: Dec1988, Vol. 78 Issue 12, p1586; Subject Term: SMOKELESS tobacco; Subject Term: NATIVE Americans; Subject Term: SURVEYS; Subject Term: TEENAGERS; Subject Term: TOBACCO industry; Subject Term: SMOKELESS tobacco industry; Subject Term: SCHOOL districts; Subject Term: WOMEN consumers; Subject Term: UNITED States; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 111910 Tobacco Farming; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaczmarek, Ronald G.
AU - Moore Jr., Roscoe M.
AU - Keppel, Kenneth G.
AU - Placek, Paul J.
T1 - X-Ray Examinations during Pregnancy: National Natality Surveys, 1963 and 1980.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/01//
VL - 79
IS - 1
M3 - Article
SP - 75
EP - 77
PB - American Public Health Association
SN - 00900036
AB - Based on 1963 and 1980 National Natality Surveys, the rate of medical x-ray examinations during pregnancy per 100 mothers fell 34.2 percent. A decrease in chest x-ray examinations accounted for almost all of the decline in total x-ray examinations. The reductions were greater for older mothers and those who were not White. While the number of births fell from 4,071,000 in 1963 to 3,612,000 in 1980, the number of pelvimetry examinations actually increased by 45,000. (Am J Public Health 1989; 79:75-77.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - X-rays
KW - PUBLIC health
KW - PREGNANCY
KW - SURVEYS
KW - MOTHERS
KW - WOMEN
KW - CLINICAL medicine -- Research
KW - CLINICAL trials
KW - THERAPEUTICS
KW - MEDICAL care
N1 - Accession Number: 4685502; Kaczmarek, Ronald G. 1 Moore Jr., Roscoe M. 1 Keppel, Kenneth G. 1 Placek, Paul J. 1; Affiliation: 1: Center fro Devices and Radiological Health (CDRH) of the Food and Drug Administration; Source Info: Jan1989, Vol. 79 Issue 1, p75; Subject Term: X-rays; Subject Term: PUBLIC health; Subject Term: PREGNANCY; Subject Term: SURVEYS; Subject Term: MOTHERS; Subject Term: WOMEN; Subject Term: CLINICAL medicine -- Research; Subject Term: CLINICAL trials; Subject Term: THERAPEUTICS; Subject Term: MEDICAL care; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, David J.
AU - Mathias, C. G. Toby
AU - Greewald, Dawn I.
T1 - Contact dermatitis from B. subtilis -derived protease enzymes.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1989/01//
VL - 20
IS - 1
M3 - Article
SP - 58
EP - 59
SN - 01051873
AB - The article reports about a 35-year old man, with no previous dermatological history, who developed palmar dermatitis after 5 months in a large bakery. Approximately 2 days per week, he worked as a mixer, manually adding to the dough ingredients including sodium sulfite, phospholux, gelatin and tablets of concentrated proteolytic enzymes derived from bacillus subtilis. It was found that the patient most likely had contact dermatitis from the irritancy of direct skin contact with bacillus subtilis. Supplier material safety data sheets and manufacturer precautions recommended avoidance of direct skin contact with these enzymes.
KW - CONTACT dermatitis
KW - BACILLUS subtilis
KW - BAKERY employees
KW - DISEASES
KW - PROTEOLYTIC enzymes
KW - SKIN -- Inflammation
KW - BAKING industry
N1 - Accession Number: 12015396; Smith, David J. 1 Mathias, C. G. Toby 2 Greewald, Dawn I. 3; Affiliation: 1: Clinical Studies Division, Department of Environmental Health, 5251 Medical Sciences Bldg. (ML 182), 231 Bethesda Avenue, Cineinnati, Ohio 45267-0182, USA. 2: Department of Dermatology, University of Cineinnati College of Medicine, Ohio, USA. 3: Division of Surveillance, Hazard Evalluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; Source Info: Jan1989, Vol. 20 Issue 1, p58; Subject Term: CONTACT dermatitis; Subject Term: BACILLUS subtilis; Subject Term: BAKERY employees; Subject Term: DISEASES; Subject Term: PROTEOLYTIC enzymes; Subject Term: SKIN -- Inflammation; Subject Term: BAKING industry; NAICS/Industry Codes: 311811 Retail Bakeries; NAICS/Industry Codes: 311821 Cookie and Cracker Manufacturing; NAICS/Industry Codes: 445291 Baked Goods Stores; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 311813 Frozen Cakes, Pies, and Other Pastries Manufacturing; NAICS/Industry Codes: 311812 Commercial Bakeries; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0536.ep12015396
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williamson, David F.
AU - Serdula, Mary K.
AU - Kendrick, Juliette S.
AU - Binkin, Nancy J.
T1 - Comparing the Prevalence of Smoking in Pregnant and Nonpregnant Women, 1985 to 1986.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/06/
VL - 261
IS - 1
M3 - Article
SP - 70
EP - 74
SN - 00987484
AB - Provides interim estimates of the difference in the prevalence of smoking between pregnant and nonpregnant women in the U.S. overall and by age, race and education. Smoking behavior of unmarried pregnant women; Use of cross-sectional data collected from 1985 through 1986 from 25 states and the District of Columbia, in which pregnant and nonpregnant women were included in the same sampling frame.
KW - PREGNANT women -- Tobacco use
KW - WOMEN -- Substance use
KW - DEMOGRAPHY
KW - UNITED States
N1 - Accession Number: 10949529; Williamson, David F. 1 Serdula, Mary K. 1 Kendrick, Juliette S. 1 Binkin, Nancy J. 1; Affiliation: 1: Department of Health and Human Services, Public Health Service, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta; Source Info: 1/6/89, Vol. 261 Issue 1, p70; Subject Term: PREGNANT women -- Tobacco use; Subject Term: WOMEN -- Substance use; Subject Term: DEMOGRAPHY; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Koop, C. Everett
T1 - The Silver Anniversary.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/01/06/
VL - 261
IS - 1
M3 - Editorial
SP - 98
EP - 99
SN - 00987484
AB - Editorial. Analyzes the major developments related to smoking and health that have occurred in the U.S. since 1964, the year in which the historic report of the Surgeon General's Advisory Committee on Smoking and Health was released to then Surgeon General Luther L. Terry. Decrease in the prevalence of cigarette smoking among adults; Profitability of the cigarette industry despite declining sales.
KW - SMOKING
KW - CIGARETTE industry
KW - UNITED States
KW - TERRY, Luther L. (Luther Leonidas), 1911-1985
N1 - Accession Number: 10949535; Koop, C. Everett 1; Affiliation: 1: Surgeon General, Public Health Service, Rockville, Md; Source Info: 1/6/89, Vol. 261 Issue 1, p98; Subject Term: SMOKING; Subject Term: CIGARETTE industry; Subject Term: UNITED States; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 312220 Tobacco product manufacturing; People: TERRY, Luther L. (Luther Leonidas), 1911-1985; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pierce, John P.
T1 - International Comparisons of Trends in Cigarette Smoking Prevalence.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/02//
VL - 79
IS - 2
M3 - Article
SP - 152
EP - 157
PB - American Public Health Association
SN - 00900036
AB - Data on smoking prevalence since 1974 are presented for the United States, Canada, Great Britain, Australia, Norway and Sweden. During this period, sex-specific prevalence has decreased in all the countries, studied, with the exception of Norway, where women showed an increase. There are also a considerable decline in uptake of smoking by the young over this period, suggestion that the observed decline in prevalence is likely to continue. In the United States, the rate of decline in adult smoking prevalence has been linear. This linear pattern is probably similar in prevalence in most other countries studied, with the notable exception of Australia, which demonstrated no change for the majority of the period. Among the six countries studied, the United States had neither the lowest smoking prevalence nor the fastest rate of decline over the period. Differential patterns of change infer that the successful public health interventions in some countries are not being applied in others. While the lack of change in Australia prior to 1983 is surprising, this was followed by a sizable drop in smoking prevalence for both higher and lower educational group in conjunction with the introduction of mass media-led antismoking campaigns. Most of the other countries report an ever increasing gap in prevalence between higher and lower educational groups. These findings suggest that all countries might benefit from a greater exchange of antismoking ideas and public health action. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - EVALUATION
KW - CIGARETTE smokers
KW - RESEARCH
KW - CIGAR smoking
KW - ABSTRACTS
KW - UNITED States
KW - AUSTRALIA
KW - GREAT Britain
N1 - Accession Number: 4682697; Pierce, John P. 1; Affiliation: 1: Office on Smoking and Health, Center for Chromic Disease Prevention, Centers for Disease Control, US Public Health Service; Source Info: Feb1989, Vol. 79 Issue 2, p152; Subject Term: SMOKING; Subject Term: EVALUATION; Subject Term: CIGARETTE smokers; Subject Term: RESEARCH; Subject Term: CIGAR smoking; Subject Term: ABSTRACTS; Subject Term: UNITED States; Subject Term: AUSTRALIA; Subject Term: GREAT Britain; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yancey, Kim B.
AU - Lawley, Thomas J.
AU - Dersookian, Mirra
AU - Harvath, Liana
T1 - Analysis of the Interaction of Human C5a and C5a des Arg with Human Monocytes and Neutrophils: Flow Cytometric and Chemotaxis Studies.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1989/02//
VL - 92
IS - 2
M3 - Article
SP - 184
EP - 189
SN - 0022202X
AB - C5a and C5a des Arg are potent complement-derived mediators that bind receptors on peripheral blood leukocytes and tissue-specific cellular elements to elicit and amplify inflammatory and immunomodulatory reactions. To study the interactions of C5a and C5a des Arg with these cells, fluorescein conjugates of these ligands were prepared by a new technique and their binding to monocytes, neutrophils, platelets, and endothelial cells was studied with flow cytometry. Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities. Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes. Ligand binding was specifically inhibited by native purified human C5a in a concentration-dependent manner, while it was unaffected by C3a or N-formyl-methionyl- leucylphenylalanine-lysine. There was no evidence of a C5a receptor-negative subpopulation of monocytes or neutrophils. Moreover, comparative binding experiments with leukocytes from multiple normal volunteers showed that a greater percentage of monocytes than neutrophils bound C5a at less than saturable concentrations of ligand (P < 0.05, 0.5 to 5.0 nM). A representative half-maximal binding of fluorescein-conjugated C5a (C5a des Arg) binding to monocytes and neutrophils was 1.2 nM (30 nM) and 2.6 nM (68 nM), respectively. In contrast, fluorescein-conjugated C5a did not specifically bind to human platelets or umbilical vein endothelial cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCYTES
KW - NEUTROPHILS
KW - CHEMOTAXIS
KW - LEUCOCYTES
KW - FLUORESCEIN
KW - CYTOMETRY
N1 - Accession Number: 12276710; Yancey, Kim B. 1 Lawley, Thomas J. 2 Dersookian, Mirra 1 Harvath, Liana 3; Affiliation: 1: Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. 2: Dermatology Branch, National Cancer Institute, National institutes of Health, Bethesda, Maryland. 3: Division of Blood and Blood Products, Office of Biologics Research and Review, Center for Drugs and Biologics, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Feb89, Vol. 92 Issue 2, p184; Subject Term: MONOCYTES; Subject Term: NEUTROPHILS; Subject Term: CHEMOTAXIS; Subject Term: LEUCOCYTES; Subject Term: FLUORESCEIN; Subject Term: CYTOMETRY; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12276710
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graitcer, Philip L.
T1 - Evaluating Community Interventions to Reduce Drunken Driving.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/03//
VL - 79
IS - 3
M3 - Article
SP - 271
EP - 271
PB - American Public Health Association
SN - 00900036
AB - The article introduces reports published within the issue, including one on the decreased incidence of automobile fatalities involving alcohol, and another on a successful community injury intervention designed to train drivers to self-regulate their blood alcohol concentrations.
KW - PREFACES & forewords
KW - TRAFFIC accidents
N1 - Accession Number: 4685134; Graitcer, Philip L. 1; Affiliation: 1: Division of Injury Epidemiology and Control (Mail Stop F36), Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333; Source Info: Mar1989, Vol. 79 Issue 3, p271; Subject Term: PREFACES & forewords; Subject Term: TRAFFIC accidents; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tanaka, Shiro
AU - Lee, Shiu T.
AU - Halperin, William E.
AU - Thun, Michael
AU - Smith, Blair
T1 - Reducing Knee Morbidity among Carpetlayers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/03//
VL - 79
IS - 3
M3 - Article
SP - 334
EP - 335
PB - American Public Health Association
SN - 00900036
AB - Abstract: Carpetlayers have a high prevalence of occupational knee morbidity, partly attributable to their use of the knee kicker to stretch carpet for wall-to-wall installation. While a mechanical alternative "power stretcher" is available, knee kickers are still widely used. A questionnaire survey indicated that unavailability of the mechanical stretcher at installation sites was a major factor for continued use of the knee kicker. Strategies to reduce use of the knee kicker are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KNEE -- Diseases
KW - CARPET laying
KW - SOCIAL science research
KW - OCCUPATIONAL diseases
KW - DISEASES
KW - JOINTS (Anatomy)
KW - EQUIPMENT & supplies
KW - TEXTILES
KW - MUSCULOSKELETAL system
N1 - Accession Number: 4685343; Tanaka, Shiro 1 Lee, Shiu T. 1 Halperin, William E. 1 Thun, Michael 1 Smith, Blair 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Mar1989, Vol. 79 Issue 3, p334; Subject Term: KNEE -- Diseases; Subject Term: CARPET laying; Subject Term: SOCIAL science research; Subject Term: OCCUPATIONAL diseases; Subject Term: DISEASES; Subject Term: JOINTS (Anatomy); Subject Term: EQUIPMENT & supplies; Subject Term: TEXTILES; Subject Term: MUSCULOSKELETAL system; NAICS/Industry Codes: 238330 Flooring Contractors; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 424310 Piece Goods, Notions, and Other Dry Goods Merchant Wholesalers; NAICS/Industry Codes: 414130 Piece goods, notions and other dry goods merchant wholesalers; NAICS/Industry Codes: 314999 All Other Miscellaneous Textile Product Mills; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sugarman, Jonathan
AU - Percy, Carol
T1 - Prevalence of Diabetes in a Navajo Indian Community.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/04//
VL - 79
IS - 4
M3 - Article
SP - 511
EP - 513
PB - American Public Health Association
SN - 00900036
AB - Abstract: The age- and sex-adjusted prevalence of non-insulin-dependent diabetes mellitus (NIDDM) of 494 (76 per ¢) Navajo adults living in a reservation community was 10.2 per ¢, approximately 60 per ¢ > the estimated prevalence (6.4 per ¢) in the general US population. The screening protocol utilized likely underestimates the prevalence of NIDDM in this population. A high proportion of Navajo people were overweight when compared to the general US population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-insulin-dependent diabetes
KW - OLDER Navajo people
KW - OVERWEIGHT persons
KW - DIABETES
KW - CARBOHYDRATE intolerance
KW - ENDOCRINE diseases
KW - NUTRITION disorders
KW - POPULATION
KW - UNITED States
N1 - Accession Number: 4695578; Sugarman, Jonathan 1 Percy, Carol 1; Affiliation: 1: Public Health Service Hospital, Indian Health Service; Source Info: Apr89, Vol. 79 Issue 4, p511; Subject Term: NON-insulin-dependent diabetes; Subject Term: OLDER Navajo people; Subject Term: OVERWEIGHT persons; Subject Term: DIABETES; Subject Term: CARBOHYDRATE intolerance; Subject Term: ENDOCRINE diseases; Subject Term: NUTRITION disorders; Subject Term: POPULATION; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Ashley M.
AU - Rusnock, Eileen J.
AU - Sciubba, James J.
AU - Baum, Bruce J.
T1 - Establishment and characterization of an epithelial cell line from the rat submandibular gland.
JO - Journal of Oral Pathology & Medicine
JF - Journal of Oral Pathology & Medicine
Y1 - 1989/04//
VL - 18
IS - 4
M3 - Article
SP - 206
EP - 213
SN - 09042512
AB - An epithelial cell line, RSMT[SUBx], has been established from the submandibular gland of weanling Fisher 344 rats by treatment of explanted tissue clumps with 3-methylocholanthrene. These cells exhibit a polygonal shape on light microscopy and a polar appearance, with desmosomes, terminal bar-like structures, surface microvilli and cytoplasmic interdigitations, when examined by electron microscopy. The cells react positively with an antiserum to cytoskeletal keratin, and a commercial monoclonal antibody to an "epithelial membrane antigen," An antiserum, prepared against early passage cells in hamsters, reacts primarily with ductal elements in tissue sections of submandibular gland, as does an antiserum prepared in mice with late passage cells. The cells are easily passaged and have been maintained for more than two years in continuous culture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIAL cells
KW - EPITHELIUM
KW - SUBMANDIBULAR gland
KW - SALIVARY glands
KW - RATS
KW - CELL culture
KW - Cell culture
KW - epithelium
KW - rat
KW - salivary glands.
N1 - Accession Number: 11658923; Brown, Ashley M. 1 Rusnock, Eileen J. 2 Sciubba, James J. 3 Baum, Bruce J. 4; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville Maryland. 2: Department of Pathology, Georgetown University Medical Center, Washington, D.C. 3: Department of Dentistry, Long Island Jewish Medical Center, New Hyde Park, New York. 4: Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institute of Health, Bethesda, Maryland, USA.; Source Info: Apr1989, Vol. 18 Issue 4, p206; Subject Term: EPITHELIAL cells; Subject Term: EPITHELIUM; Subject Term: SUBMANDIBULAR gland; Subject Term: SALIVARY glands; Subject Term: RATS; Subject Term: CELL culture; Author-Supplied Keyword: Cell culture; Author-Supplied Keyword: epithelium; Author-Supplied Keyword: rat; Author-Supplied Keyword: salivary glands.; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1600-0714.ep11658923
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cooper, Ellen C.
AU - Cooper, E C
T1 - Controlled clinical trials of AIDS drugs: the best hope.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/04/28/
VL - 261
IS - 16
M3 - journal article
SP - 2445
EP - 2445
SN - 00987484
AB - Focuses on the conduct of controlled clinical trials for anti-AIDS drugs in the U.S. Government position on the use of AIDS drugs; Effect of controlled trials on patient access to AIDS drugs.
KW - AIDS (Disease) -- Treatment
KW - CLINICAL trials
KW - HEALTH services accessibility
KW - UNITED States
N1 - Accession Number: 10865624; Cooper, Ellen C. Cooper, E C 1; Affiliation: 1: Division of Anti-Viral Drug Products, Food and Drug Administration; Source Info: 4/28/89, Vol. 261 Issue 16, p2445; Subject Term: AIDS (Disease) -- Treatment; Subject Term: CLINICAL trials; Subject Term: HEALTH services accessibility; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nightingale, Stuart I.
AU - Rheinstein, Peter H.
AU - Morrison, James C.
T1 - To the Editor.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/05/05/
VL - 261
IS - 17
M3 - Article
SP - 2499
SN - 00987484
AB - Comments on the article 'Increased Seizure Frequency With Generic Primodone,' by Elaine Wyllie and colleagues at the Cleveland Clinic Foundation and published in the September 4, 1987 issue of the Journal of the American Medical Association. Description of the poor response of one patient to administration of primidone for the control of epileptic seizures; Outcome of the investigation conducted by the U.S. Food and Drug Administration on the case.
KW - CONVULSIONS
KW - DRUGS -- Side effects
KW - EPILEPSY
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 10811121; Nightingale, Stuart I. 1 Rheinstein, Peter H. 1 Morrison, James C. 1; Affiliation: 1: U.S. Food and Drug Administration; Source Info: 5/5/89, Vol. 261 Issue 17, p2499; Subject Term: CONVULSIONS; Subject Term: DRUGS -- Side effects; Subject Term: EPILEPSY; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scallet, Andrew C.
AU - McKay, Daniel
AU - Baley, John R.
AU - Ali, Syed F.
AU - Paule, Merle G.
AU - Slikker, Jr., William
AU - Rayford, Phillip L.
T1 - Meal-Induced Increase in Plasma Gastrin Immunoreactivity in the Rhesus Monkey (Macaca mulatta).
JO - American Journal of Primatology
JF - American Journal of Primatology
Y1 - 1989/08//
VL - 18
IS - 4
M3 - Article
SP - 315
EP - 319
SN - 02752565
AB - The hormonal response to food intake in rodents, dogs, and humans involves gastrin and cholecystokinin, structurally related peptides present in plasma, gut, and brain. In order to determine the time course of plasma gastrin response in a nonhuman primate, six overnight-fasted adult male rhesus monkeys were offered a meal of bananas (11 g) and peanut butter (1 Tbsp) or a fresh water bottle in a crossover design. All animals completely consumed the meal within 10 min. Compared to non-fed control levels, plasma gastrin was significantly elevated (52 ± 11 pM vs. 32 ± 9 pM, means ± S.E.M.) from 10 to 45 post-ingestion, but returned to near basal fasted level by 120 min. Levels of gastrin in tissue samples (n = 2) were highest in the antrum of the stomach, with decreasing amounts measured in the upper and lower duodenum, respectively. The results demonstrate that the plasma concentration and response to a meal of rhesus monkey gastrin are similar to those of other mammalian species. However, the high concentrations of gastrin found in duodenum are thus far unique to Macaca mulatta and humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Primatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INGESTION
KW - GASTRIN
KW - CHOLECYSTOKININ
KW - PEPTIDES
KW - RODENTS
KW - DOGS
KW - antrum
KW - cholecystokinin
KW - duodenum
KW - feeding
KW - radioimmunoassay
KW - stomach
N1 - Accession Number: 12313545; Scallet, Andrew C. 1,2 McKay, Daniel 3 Baley, John R. 1 Ali, Syed F. 1 Paule, Merle G. 1,2 Slikker, Jr., William 1,2 Rayford, Phillip L. 3; Affiliation: 1: Pharmacodynamics Brach, Division of Reproductive and Development Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 2: Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock 3: Development of Physiology; Source Info: 1989, Vol. 18 Issue 4, p315; Subject Term: INGESTION; Subject Term: GASTRIN; Subject Term: CHOLECYSTOKININ; Subject Term: PEPTIDES; Subject Term: RODENTS; Subject Term: DOGS; Author-Supplied Keyword: antrum; Author-Supplied Keyword: cholecystokinin; Author-Supplied Keyword: duodenum; Author-Supplied Keyword: feeding; Author-Supplied Keyword: radioimmunoassay; Author-Supplied Keyword: stomach; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valway, Sarah E.
AU - Martyny, John W.
AU - Miller, Jeffrey R.
AU - Cook, Magdalena
AU - Mangione, Ellen J.
T1 - Lead Absorption in Indoor Firing Range Users.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/08//
VL - 79
IS - 8
M3 - Article
SP - 1029
EP - 1032
PB - American Public Health Association
SN - 00900036
AB - Abstract: To determine if users of indoor firing ranges may be at risk from lead exposure, we studied a law enforcement trainee class during three months of firearms instruction. Blood lead levels were obtained before training and at four-week intervals during training. Air lead levels were measured three times during instruction. Blood lead levels rose from a pre-training mean of 0,31 µ mol/L to 2.47 µ mol/ L. Mean air lead levels were above 2,000 µ g/m&sup 3;, more than 40 times the Occupational Safety and Health Administration's standard of 50 µ g/m&sup 3;. Cumulative exposure to lead and the change in blood lead were positively correlated. Control measures need to be studied to determine their efficacy in decreasing or eliminating this health risk. (Am J Public Health 1989; 79:1029-1032.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAD -- Toxicology
KW - BOMBING & gunnery ranges
KW - PUBLIC health
KW - LAW enforcement
KW - FIREARMS
KW - POLICE training
KW - INDUSTRIAL safety
KW - GOVERNMENT agencies
KW - BLOOD analysis
N1 - Accession Number: 4685364; Valway, Sarah E. 1,2 Martyny, John W. 3 Miller, Jeffrey R. 4 Cook, Magdalena 4 Mangione, Ellen J. 4; Affiliation: 1: Medical Epidemiologist, Diabetes Program, Indian Health Service, 2401 12th Street, NW, Albuquerque, NM 87102 2: Division of Field Services, Epidemiology Program, Centers for Disease Control 3: Tri-County Health Department, Englewood, CO. 4: Colorado Department of Health, Division of Disease Control and Environmental Epidemiology, Denver; Source Info: Aug1989, Vol. 79 Issue 8, p1029; Subject Term: LEAD -- Toxicology; Subject Term: BOMBING & gunnery ranges; Subject Term: PUBLIC health; Subject Term: LAW enforcement; Subject Term: FIREARMS; Subject Term: POLICE training; Subject Term: INDUSTRIAL safety; Subject Term: GOVERNMENT agencies; Subject Term: BLOOD analysis; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 332992 Small Arms Ammunition Manufacturing; NAICS/Industry Codes: 451119 All other sporting goods stores; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 611519 Other Technical and Trade Schools; NAICS/Industry Codes: 611510 Technical and trade schools; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roscoe, Robert J.
AU - Steenland, Kyle
AU - Halperin, William E.
AU - Beaumont, James J.
AU - Waxweiler, Richard J.
T1 - Lung Cancer Mortality Among Nonsmoking Uranium Miners Exposed to Radon Daughters.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/08/04/
VL - 262
IS - 5
M3 - Article
SP - 629
EP - 633
SN - 00987484
AB - Estimates the risk of lung cancer mortality among nonsmokers exposed to varying levels of radon daughters. Comparison of observations between white miners with no smoking experience and mortality rates for nonsmokers of U.S. Veterans; Revelation of more deaths with the miners group; Confirmation of radon exposure's carcinogen potency.
KW - LUNGS -- Cancer
KW - PASSIVE smoking
KW - RADON
KW - MINERS
KW - CARCINOGENS
N1 - Accession Number: 10940888; Roscoe, Robert J. 1 Steenland, Kyle 1 Halperin, William E. 2 Beaumont, James J. 3 Waxweiler, Richard J. 4; Affiliation: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati 2: Harvard School of Public Health, Boston 3: Division of Occupational and Environmental Medicine, University of California at Davis 4: Epidemiology Branch, Division of Injury Epidemiology and Control, Center for Environmental Health and Injury Control, Centers for Disease Control, Atlanta; Source Info: 8/4/89, Vol. 262 Issue 5, p629; Subject Term: LUNGS -- Cancer; Subject Term: PASSIVE smoking; Subject Term: RADON; Subject Term: MINERS; Subject Term: CARCINOGENS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ford, Daniel E.
AU - Kamerow, Douglas B.
T1 - Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/09/15/
VL - 262
IS - 11
M3 - Article
SP - 1479
EP - 1484
SN - 00987484
AB - Presents the results of a survey on the relationship between sleep disturbances and psychiatric disorders in the U.S. Risk of developing new major depression in persons who had insomnia; Prevalence and incidence of sleep disturbances; Relationship between age and insomnia and hypersomnia; Descriptive epidemiology.
KW - SLEEP disorders
KW - PSYCHIATRY
KW - MENTAL depression
KW - INSOMNIA
KW - UNITED States
N1 - Accession Number: 10982576; Ford, Daniel E. 1 Kamerow, Douglas B. 2; Affiliation: 1: Division of Internal Medicine, Baltimore, Md 2: Office of Disease Prevention and Health Promotion, US Public Health Service, Washington, DC; Source Info: 9/15/89, Vol. 262 Issue 11, p1479; Subject Term: SLEEP disorders; Subject Term: PSYCHIATRY; Subject Term: MENTAL depression; Subject Term: INSOMNIA; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Ginzburg, Harold M.
T1 - Needle Exchange Programs: A Medical or a Policy Dilemma?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/10//
VL - 79
IS - 10
M3 - Editorial
SP - 1350
EP - 1351
PB - American Public Health Association
SN - 00900036
AB - The article offers reports in connection with the needle exchange programs. The program aims to contain HIV in medical communities, due to sharing contaminated needles and syringes with infected partners. The section discusses the effects of the program in several cities in the United States. It also provides several insights given by some professionals in medical care regarding the program.
KW - AIDS (Disease) -- Prevention
KW - IMMUNOLOGICAL deficiency syndromes
KW - HIV (Viruses)
KW - COMMUNICABLE diseases
KW - SEXUALLY transmitted diseases
N1 - Accession Number: 4685606; Ginzburg, Harold M. 1; Affiliation: 1: Senior Medical Consultant, Bureau of Health Care Delivery and Assistance, Health Resources and Services Administration, Room 7-05, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Oct89, Vol. 79 Issue 10, p1350; Subject Term: AIDS (Disease) -- Prevention; Subject Term: IMMUNOLOGICAL deficiency syndromes; Subject Term: HIV (Viruses); Subject Term: COMMUNICABLE diseases; Subject Term: SEXUALLY transmitted diseases; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Donohue, Robert E.
AU - Fauver, H. Earl
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/10/06/
VL - 262
IS - 13
M3 - Letter
SP - 1772
EP - 1772
SN - 00987484
AB - Presents a letter to the editor in the October 6, 1989 issue of the 'Journal of the American Medical Association,' noting that it is warranted to perform a renal ultrasound examination in patients who present with bilateral absence of the vas deferens.
KW - ULTRASONIC imaging
KW - KIDNEYS
KW - VAS deferens
KW - LETTERS to the editor
N1 - Accession Number: 10981843; Donohue, Robert E. 1 Fauver, H. Earl 2; Affiliation: 1: University of Colorado Health Sciences Center, Denver 2: Graduate Medical Education Office of the Surgeon General of the Army, Washington, DC; Source Info: 10/6/89, Vol. 262 Issue 13, p1772; Subject Term: ULTRASONIC imaging; Subject Term: KIDNEYS; Subject Term: VAS deferens; Subject Term: LETTERS to the editor; Number of Pages: 1/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Freund, Eugene
AU - Seligman, Paul J.
AU - Chorba, Terence L.
AU - Safford, Susan K.
AU - Drachman, Jonathan G.
AU - Hull, Harry F.
T1 - Mandatory Reporting of Occupational Diseases by Clinicians.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12//12/1/89
VL - 262
IS - 21
M3 - Article
SP - 3041
EP - 3044
SN - 00987484
AB - Focuses on the policy of mandatory reporting of occupational diseases by clinicians in the United States. Importance of occupational disease surveillance on the prevention of work-related injury and illness; Programs launched by states for occupational safety and health; Reportable occupational diseases and occupational disease-related conditions in the country.
KW - OCCUPATIONAL diseases
KW - MEDICAL policy
KW - REPORTING
KW - UNITED States
N1 - Accession Number: 10982450; Freund, Eugene 1 Seligman, Paul J. 1 Chorba, Terence L. 2 Safford, Susan K. 2 Drachman, Jonathan G. 2 Hull, Harry F. 3; Affiliation: 1: Medical Section, Surveillance Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control, Ohio 2: Epidemiology Program Office, Centers for Disease Control, Ga 3: New Mexico Health and Environment Department, Santa Fe; Source Info: 12/1/89, Vol. 262 Issue 21, p3041; Subject Term: OCCUPATIONAL diseases; Subject Term: MEDICAL policy; Subject Term: REPORTING; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bakfr, Edward L.
AU - Honchar, Patricia A.
AU - Fine, Lawrence J.
T1 - I. Surveillance in Occupational Illness and Injury: Concepts and Content.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 9
EP - 11
PB - American Public Health Association
SN - 00900036
AB - The article discusses the nature and significance of surveillance programs in occupational health. Occupational surveillance programs gather data and information which will provide an overview of a particular illness or injury. The complex needs of the field of occupational health is an obstacle in coming up with a single approach to surveillance. The improvements in data systems have helped determined innovative ways to utilize surveillance data to anticipate occupational diseases and complaints.
KW - OCCUPATIONAL health services
KW - MEDICAL care
KW - MEDICAL research
KW - HEALTH status indicators
KW - DISEASES
KW - OCCUPATIONAL diseases
KW - INDUSTRIAL hygiene
KW - CLINICAL pathology
KW - ELECTRONIC health records
N1 - Accession Number: 4690735; Bakfr, Edward L. 1 Honchar, Patricia A. 2 Fine, Lawrence J. 3; Affiliation: 1: Deputy Director, National Institute for Occupational Safety and Health Centers for Disease Control 2: Division of injury Epidemiology and Control Center for Environmental Health and Injury Control Centers for Disease Control 3: Director Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health Centers for Disease Control; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p9; Subject Term: OCCUPATIONAL health services; Subject Term: MEDICAL care; Subject Term: MEDICAL research; Subject Term: HEALTH status indicators; Subject Term: DISEASES; Subject Term: OCCUPATIONAL diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: CLINICAL pathology; Subject Term: ELECTRONIC health records; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ehrenberg, Richard L.
T1 - II. Use of Direct Surveys in the Surveillance of Occupational Illness and Injury.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 12
EP - 14
PB - American Public Health Association
SN - 00900036
AB - The application of direct surveys in the surveillance of occupational illness is discussed. Direct surveys collect information systematically through a specific sampling procedure which makes it an effective tool in gathering surveillance data for work-related injuries and ill health. Prevalent conditions can be determined by surveys through survey questioners or diagnostic tests. Direct surveys give pertinent data pertaining to the health status of an individual which will be useful in making precise health assessment
KW - HEALTH surveys
KW - OCCUPATIONAL health services
KW - SURVEYS
KW - DISEASES -- Causes & theories of causation
KW - PATHOLOGY
KW - MEDICAL research
KW - INDUSTRIAL safety
KW - HEALTH status indicators
KW - MEDICAL care surveys
N1 - Accession Number: 4690742; Ehrenberg, Richard L. 1; Affiliation: 1: Senior Medical Epidemiologist National institute for Occupational Safety and Health Centers for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p12; Subject Term: HEALTH surveys; Subject Term: OCCUPATIONAL health services; Subject Term: SURVEYS; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: PATHOLOGY; Subject Term: MEDICAL research; Subject Term: INDUSTRIAL safety; Subject Term: HEALTH status indicators; Subject Term: MEDICAL care surveys; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ehrenberg, Richard L.
AU - Sniezek, Joseph E.
T1 - III. Development of a Standard Questionnaire for Occupational Health Research.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 15
EP - 17
PB - American Public Health Association
SN - 00900036
AB - The article discusses the development of a standard questionnaire used in direct surveys for occupational health research. A standardized method takes precedence in developing a questionnaire otherwise variations will occur in the study itself and other related surveys. The set of predetermined questions presented in a specific order provides for the standard of a questionnaire. A standard questionnaire is designed to collect information in a precise and consistent manner to reflect the exact interpretation of the data collected.
KW - HEALTH surveys
KW - QUESTIONNAIRES
KW - HEALTH status indicators
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL health services
KW - RESEARCH -- Methodology
KW - OCCUPATIONAL medicine
KW - HEALTH surveys -- Statistical methods
KW - MEDICAL statistics
KW - QUESTIONS & answers
N1 - Accession Number: 4690749; Ehrenberg, Richard L. 1 Sniezek, Joseph E. 2; Affiliation: 1: Senior Medical Epidemiologist, National Institute for Occupational Safety and Health,Centers For Disease Control. 2: Medical Epidemiologist Center for Environmental Health and Injury Control Centers for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p15; Subject Term: HEALTH surveys; Subject Term: QUESTIONNAIRES; Subject Term: HEALTH status indicators; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL health services; Subject Term: RESEARCH -- Methodology; Subject Term: OCCUPATIONAL medicine; Subject Term: HEALTH surveys -- Statistical methods; Subject Term: MEDICAL statistics; Subject Term: QUESTIONS & answers; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Edward L
T1 - IV. Sentinel Event Notification System for Occupational Risks (SENSOR): The Concept.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 18
EP - 20
PB - American Public Health Association
SN - 00900036
AB - The Sentinel Event Notification System for Occupational Risk (SENSOR) is discussed. SENSOR was created to provide a framework for an active approach to six selected occupational disorders in the state-federal level. It is a provider-reporting system which aims to develop a uniform and prompt follow-up and surveillance for occupational illness and injury and thereby provide preventive measures for such illnesses. The advancement of SENSOR is cited as a step towards developing a comprehensive surveillance system for occupational diseases in the United States.
KW - OCCUPATIONAL health services
KW - OCCUPATIONAL diseases
KW - OCCUPATIONAL medicine
KW - INDUSTRIAL hygiene
KW - SENTINEL health events
KW - HEALTH status indicators
KW - PUBLIC health surveillance
KW - REPORTING of diseases
KW - MEDICAL care
KW - REPORTING
KW - UNITED States
N1 - Accession Number: 4690765; Baker, Edward L 1; Affiliation: 1: Deputy Directors National institute for Occupational Safety and Health Centers for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p18; Subject Term: OCCUPATIONAL health services; Subject Term: OCCUPATIONAL diseases; Subject Term: OCCUPATIONAL medicine; Subject Term: INDUSTRIAL hygiene; Subject Term: SENTINEL health events; Subject Term: HEALTH status indicators; Subject Term: PUBLIC health surveillance; Subject Term: REPORTING of diseases; Subject Term: MEDICAL care; Subject Term: REPORTING; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Matte, Thomas D.
AU - Baker, Edward L.
AU - Honchar, Patricia A.
T1 - V. The Selection and Definition of Targeted Work-Related Conditions for Surveillance under SENSOR.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 21
EP - 25
PB - American Public Health Association
SN - 00900036
AB - The article discusses the need to develop a list of work-related conditions which are relevant targets in state-based Sentinel Event Notification System for Occupational Risk (SENSOR). The availability of the list will focus the efforts of SENSOR projects, clarify reporting requirements for providers and promote state-based surveillance of occupational health problems of national significance. A list of prevalent diseases has benefited national surveillance priorities. Knowledge and experience from state health projects using SENSOR is a big help in establishing condition-specific surveillance strategies on a wider scope.
KW - OCCUPATIONAL diseases
KW - INDUSTRIAL safety
KW - OCCUPATIONAL medicine
KW - EMPLOYEE health promotion
KW - HEALTH surveys
KW - PUBLIC health -- United States
KW - COOPERATIVE Health Statistics System
KW - WORK environment
KW - REPORTING
KW - UNITED States
N1 - Accession Number: 4690772; Matte, Thomas D. 1 Baker, Edward L. 2 Honchar, Patricia A. 3; Affiliation: 1: Medical Epidemiologist, Office of the Director, National Institute for Occupational Safety and Health Centers for Disease Control. 2: National Institute for Occupational Safety and Health, Centers for Disease Control. 3: Division of Injury Epidemiology and Control Center for Environmental Health and Injury Control Centers for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p21; Subject Term: OCCUPATIONAL diseases; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL medicine; Subject Term: EMPLOYEE health promotion; Subject Term: HEALTH surveys; Subject Term: PUBLIC health -- United States; Subject Term: COOPERATIVE Health Statistics System; Subject Term: WORK environment; Subject Term: REPORTING; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sundin, David S.
AU - Frazier, Todd M.
T1 - VII. Hazard Surveillance at NIOSH.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 32
EP - 37
PB - American Public Health Association
SN - 00900036
AB - The article discusses the U.S. National Institute for Occupational Safety and Health's (NIOSH) efforts for hazard surveillance, providing a summary of major project initiatives concerning occupational safety following the passage of the Occupational Safety and Health Act of 1970. By virtue of the mandates of the occupational safety act the Task Force on Hazard and Disease was created and thus recommended that the NIOSH undertake a National Occupational Hazard Survey. The purpose of which is to determine the extent of exposure to occupational hazard in the workplace.
KW - INDUSTRIAL safety -- Law & legislation
KW - HAZARDOUS substances
KW - HEALTH risk assessment
KW - RISK assessment
KW - OCCUPATIONAL diseases
KW - OCCUPATIONAL medicine
KW - THRESHOLD limit values (Industrial toxicology)
KW - EMPLOYEE health promotion
KW - HEALTH surveys
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 4690789; Sundin, David S. 1 Frazier, Todd M. 2; Affiliation: 1: Section Chief. Hazard Section Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health Centers for Disease Control. 2: Chief, Surveillance Branch Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p32; Subject Term: INDUSTRIAL safety -- Law & legislation; Subject Term: HAZARDOUS substances; Subject Term: HEALTH risk assessment; Subject Term: RISK assessment; Subject Term: OCCUPATIONAL diseases; Subject Term: OCCUPATIONAL medicine; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: EMPLOYEE health promotion; Subject Term: HEALTH surveys; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hanrahan, Lawrence P.
AU - Moll, Michael B.
T1 - VIII. Injury Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 38
EP - 45
PB - American Public Health Association
SN - 00900036
AB - Injury surveillance, the systematic collection, analysis and interpretation of data related to occupational injury including existing information systems for its implementation are discussed. The requirements of epidemiological surveillance and the limitations of the existing occupational injury databases along with areas like the need for detailed denominators, hazard monitoring, injury/event coding, reporting of health outcomes and fatality monitoring provide the basis for enhancement of injury surveillance in the United States.
KW - INDUSTRIAL safety
KW - OCCUPATIONAL medicine
KW - MEDICAL care
KW - EMPLOYEE health promotion
KW - HEALTH behavior
KW - PREVENTIVE health services
KW - RISK assessment
KW - HEALTH risk assessment
KW - RESEARCH
KW - OCCUPATIONAL health services
KW - INDUSTRIAL hygiene
KW - UNITED States
N1 - Accession Number: 4690795; Hanrahan, Lawrence P. 1 Moll, Michael B. 2; Affiliation: 1: Epidemiologist Wiconsin Department of Health and, Social Services. 2: Chief, Data Analysis Section Division of Safety Research National Institute for Occupational Safety and Health Centers for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p38; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL medicine; Subject Term: MEDICAL care; Subject Term: EMPLOYEE health promotion; Subject Term: HEALTH behavior; Subject Term: PREVENTIVE health services; Subject Term: RISK assessment; Subject Term: HEALTH risk assessment; Subject Term: RESEARCH; Subject Term: OCCUPATIONAL health services; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Melius, James M.
AU - Sestito, John P.
AU - Seligman, Paul J.
T1 - IX. Occupational Disease Surveillance with Existing Data Sources.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 46
EP - 52
PB - American Public Health Association
SN - 00900036
AB - The article discusses the utilization of existing data resources for surveillance of occupational disease. There are two aspects that limit the usefulness of existing data in occupational disease surveillance, which are, the conditions related to occupational exposure that must be included in the data system and the information on the occupation or employment setting of persons must also be included. Existing data sources can significantly contribute to the identification and control of occupational diseases in the United States.
KW - OCCUPATIONAL diseases
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL medicine
KW - EMPLOYEE health promotion
KW - HEALTH risk assessment
KW - DISEASES
KW - MEDICAL care
KW - DISEASE management
KW - MEDICAL statistics
KW - UNITED States
N1 - Accession Number: 4690803; Melius, James M. 1 Sestito, John P. 2 Seligman, Paul J. 3; Affiliation: 1: Director, Division of Occupational Health and `Environmental Epidemiology New York State Department of Health 2: Section Chief, Illness Effects Section Division of Surveillance, Hazard Evaluations and Field Studies National Institute for Occupational Safety and Health, Centers kw Disease Control 3: Chiefs Medical Section Division of Surveillance, Hazard Evacuations and Field, Studies National Institute for Occupational Safety and Health Center for Disease Control.; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p46; Subject Term: OCCUPATIONAL diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL medicine; Subject Term: EMPLOYEE health promotion; Subject Term: HEALTH risk assessment; Subject Term: DISEASES; Subject Term: MEDICAL care; Subject Term: DISEASE management; Subject Term: MEDICAL statistics; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bregman, Dennis J.
AU - Anderson, Kern E.
AU - Buffler, Patricia
AU - Salg, Joyce
T1 - X. Surveillance for Work-Related Adverse Reproductive Outcomes.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 53
EP - 57
PB - American Public Health Association
SN - 00900036
AB - Disorders in the reproductive system, which is one of the ten leading work-related disease listed by the U.S. National Institute for Occupational Safety and Health (NIOSH) is discussed. Two types of surveillance can be established to identify and control reproductive disorders in the workplace, which are, the surveillance for work-related disorders of reproduction and surveillance for physical and chemical hazards to reproductive health.The control of hazards prevents reproductive disorders as well which can be done through hazard surveillance. The strategies for surveillance of reproductive disorders need to be developed and innovative surveillance systems need to be established as well.
KW - REPRODUCTIVE health
KW - EFFECT of chemicals on human reproduction
KW - OCCUPATIONAL health services
KW - OCCUPATIONAL medicine
KW - INDUSTRIAL hygiene
KW - HEALTH risk assessment
KW - WORK environment
KW - HAZARDOUS substances
KW - RISK assessment
KW - UNITED States
N1 - Accession Number: 4690812; Bregman, Dennis J. 1 Anderson, Kern E. 2 Buffler, Patricia 3 Salg, Joyce 4; Affiliation: 1: Senior Math Statistician Division of Surveillance, Hazard Evaluations and Field Studies, National institute for Occupational Safety and Health Centers for Disease Control 2: Public Health. Advisor Division of Surveillance, Hazard Evaluations and Field Studies National institute for Occupational Safety and Health Centers for Disease Control 3: Director, Texas Educational Resources Center, University of Texas 4: Epidemiologist Division of Surveillance, Hazard Evaluations arid Field Studies National Institute for Occupational Safety and Health Centers for Disease Control; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p53; Subject Term: REPRODUCTIVE health; Subject Term: EFFECT of chemicals on human reproduction; Subject Term: OCCUPATIONAL health services; Subject Term: OCCUPATIONAL medicine; Subject Term: INDUSTRIAL hygiene; Subject Term: HEALTH risk assessment; Subject Term: WORK environment; Subject Term: HAZARDOUS substances; Subject Term: RISK assessment; Subject Term: UNITED States; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Edward L.
T1 - XII. Challenges for the Future.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1989/12/02/Dec1989 Supplement
VL - 79
IS - 12
M3 - Article
SP - 61
EP - 63
PB - American Public Health Association
SN - 00900036
AB - The developments that the occupational health surveillance has been achieving and the programs carried out to acquire new accomplishments are discussed. State-based surveillance allowed a better analysis of occupational disorders which resulted to a timely disease prevention measures. The standardization of data collection, collaboration of federal agencies and the improvement of exposure surveillance are areas with significant role in improving the occupational health surveillance mechanism. The knowledge gained in these areas provides the foundation for an effective surveillance system in occupational health practice.
KW - OCCUPATIONAL medicine
KW - RISK management in business
KW - INDUSTRIAL hygiene
KW - COMMUNICATION in industrial safety
KW - OCCUPATIONAL health services
KW - EMPLOYEE health promotion
KW - MEDICAL care surveys
KW - HEALTH facilities -- Administration
KW - UNITED States
N1 - Accession Number: 4690825; Baker, Edward L. 1; Affiliation: 1: Deputy, Director National institute for Occupational Safety and Health Centers for Disease Control; Source Info: Dec1989 Supplement, Vol. 79 Issue 12, p61; Subject Term: OCCUPATIONAL medicine; Subject Term: RISK management in business; Subject Term: INDUSTRIAL hygiene; Subject Term: COMMUNICATION in industrial safety; Subject Term: OCCUPATIONAL health services; Subject Term: EMPLOYEE health promotion; Subject Term: MEDICAL care surveys; Subject Term: HEALTH facilities -- Administration; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Roscoe, Robert J.
AU - Steenland, Kyle
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12/22/
VL - 262
IS - 24
M3 - Letter
SP - 3404
EP - 3404
SN - 00987484
AB - Presents a letter to the editor of the December 22, 1989 issue of the 'Journal of the American Medical Association' about the classification of nonsmoking uranium miners who are indeed nonsmokers in the study that determined whether radon exposure is a risk factor for lung cancer.
KW - LUNGS -- Cancer
KW - URANIUM miners
KW - RADON
KW - LETTERS to the editor
N1 - Accession Number: 10983279; Roscoe, Robert J. 1 Steenland, Kyle 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: 12/22/89-12/29/89, Vol. 262 Issue 24, p3404; Subject Term: LUNGS -- Cancer; Subject Term: URANIUM miners; Subject Term: RADON; Subject Term: LETTERS to the editor; Number of Pages: 4/9p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greene, John C.
AU - Louis, Reginald
AU - Wycoff, Samuel J.
T1 - Preventive Dentistry.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1989/12/22/
VL - 262
IS - 24
M3 - Article
SP - 3459
EP - 3463
SN - 00987484
AB - Provides background for the U.S. Preventive Services Task Force recommendations for interventions by physicians, nurses, and other clinicians, to prevent dental caries. Definition of dental caries; Preventive interventions such as fluorides, white fluoridation and dietary fluoride supplementation.
KW - DENTAL caries -- Prevention
KW - DENTAL care
KW - HEALTH
KW - UNITED States
N1 - Accession Number: 10983338; Greene, John C. 1 Louis, Reginald 2 Wycoff, Samuel J. 3; Affiliation: 1: Office of the Dean 2: Department of Dental Public Health and Hygiene 3: School of Dentistry, University of California and the Regional Office, US Public Health Service, San Francisco; Source Info: 12/22/89-12/29/89, Vol. 262 Issue 24, p3459; Subject Term: DENTAL caries -- Prevention; Subject Term: DENTAL care; Subject Term: HEALTH; Subject Term: UNITED States; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Maizlish, Neli
AU - Fine, Lawrence J.
T1 - In Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/12/
VL - 263
IS - 2
M3 - Letter
SP - 237
EP - 237
SN - 00987484
AB - Replies to comments on an article on occupational diseases and carpal tunnel syndrome.
KW - OCCUPATIONAL diseases
KW - CARPAL tunnel syndrome
N1 - Accession Number: 10982665; Maizlish, Neli 1 Fine, Lawrence J. 2; Affiliation: 1: Kate Cummings, MPH California Department of Health Services,Berkeley 2: National institute for Occupational Safety and Health, Ohio; Source Info: 1/12/90, Vol. 263 Issue 2, p237; Subject Term: OCCUPATIONAL diseases; Subject Term: CARPAL tunnel syndrome; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greene, John C.
AU - Louie, Reginald
AU - Wycoff, Samuel J.
T1 - Preventive Dentistry.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/19/
VL - 263
IS - 3
M3 - Article
SP - 421
EP - 425
SN - 00987484
AB - Part II. Discusses U.S. Preventive Services Task Force's recommendations for physicians, nurses and other clinicians to prevent oral diseases and conditions. Periodontal diseases; Malocclusion; Trauma; Oral Cancer; Collaboration with the patient's dentist; Personal oral hygiene; Combined professional and professional care.
KW - PREVENTIVE dentistry
KW - PERIODONTAL disease
KW - MALOCCLUSION
KW - ORAL cancer
KW - UNITED States
N1 - Accession Number: 10981152; Greene, John C. 1 Louie, Reginald 2 Wycoff, Samuel J. 3; Affiliation: 1: Office of the Dean, School of Dentistry, University of California 2: Regional Office, Public Health Service, San Francisco 3: Department of Dental Public Health and Hygiene, School of Dentistry, University of California; Source Info: 1/19/90, Vol. 263 Issue 3, p421; Subject Term: PREVENTIVE dentistry; Subject Term: PERIODONTAL disease; Subject Term: MALOCCLUSION; Subject Term: ORAL cancer; Subject Term: UNITED States; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawrence, Robert S.
AU - Mickalide, Angela D.
AU - Kamerow, Douglas B.
AU - Woof, Steven H.
AU - Lawrence, R S
AU - Mickalide, A D
AU - Kamerow, D B
AU - Woolf, S H
T1 - Report of the US Preventive Services Task Force.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/01/19/
VL - 263
IS - 3
M3 - commentary
SP - 436
EP - 437
SN - 00987484
AB - Discusses the 'Guide to Clinical Preventive Services: An Assessment of the Effectiveness of 169 Interventions,' by the U.S. Preventive Services Task Force. Importance of personal health practices; Shifting priorities in primary care; Designing medical practice to individual risks; Timing of preventive services; Changing role of patient.
KW - PREVENTIVE medicine
KW - MEDICAL care
KW - MEDICINE
KW - THERAPEUTICS
N1 - Accession Number: 10981095; Lawrence, Robert S. 1 Mickalide, Angela D. 2 Kamerow, Douglas B. 2 Woof, Steven H. 2 Lawrence, R S Mickalide, A D Kamerow, D B Woolf, S H; Affiliation: 1: Cambridge Hospital, Harvard Medical School 2: Office of Disease Prevention and Health Promotion, US Public Health Service, Washington, DC; Source Info: 1/19/90, Vol. 263 Issue 3, p436; Subject Term: PREVENTIVE medicine; Subject Term: MEDICAL care; Subject Term: MEDICINE; Subject Term: THERAPEUTICS; Number of Pages: 2p; Document Type: commentary
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, N. Kyle
AU - Thun, Michael J.
AU - Ferguson, C. William
AU - Port, Friedrich K.
T1 - Occupational and Other Exposures Associated with Male End-Stage Renal Disease: A Case/Control Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/02//
VL - 80
IS - 2
M3 - Article
SP - 153
EP - 157
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a case-control study of 325 men ages 30-69 who were diagnosed with end-stage renal disease (ESRD) between 1976 and 1984, and resided in four urban areas of Michigan in 1984. Cases were selected from the Michigan Kidney Registry and excluded men with diabetic, congenital, and obstructive nephropathies. Controls were selected by random-digit dialing and were pair-matched to cases for age, race, and area of residence. Telephone interviews were conducted with 69 percent of eligible cases and 79 percent of eligible controls. Risk of ESRD was significantly related to phenacetin or acetaminophen consumption (odds ratio(OR) = 2.66), moonshine consumption (OR = 2.43), a family history of renal disease (OR = 9.30); and regular occupational exposures to solvents (OR = 1.51) or silica (OR = 1.67). Particular occupational exposures with elevated risk were solvents used as cleaning agents and degreasers (OR = 2.50) silica exposure in foundries or brick factories (OR = 1.92), and silica exposure during sandblasting (OR = 3.83). Little or no trend of increased risk with duration of exposure was found for these occupational exposures, with the exception of silica in sandblasting. Limitations of these data include representativeness of cases, possible overreporting by cases, and misclassification of exposures inherent in self-reports. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC kidney failure
KW - KIDNEY diseases
KW - TELEPHONE surveys
KW - PHENACETIN
KW - ACETAMINOPHEN
KW - SOLVENTS
KW - SILICA
KW - METALWORKING industries
KW - MICHIGAN (N.D.)
KW - UNITED States
N1 - Accession Number: 4687174; Steenland, N. Kyle 1 Thun, Michael J. 1 Ferguson, C. William 2 Port, Friedrich K. 2; Affiliation: 1: National Institute for Occupational Safety and Health 2: Michigan Kidney Registry; Source Info: Feb1990, Vol. 80 Issue 2, p153; Subject Term: CHRONIC kidney failure; Subject Term: KIDNEY diseases; Subject Term: TELEPHONE surveys; Subject Term: PHENACETIN; Subject Term: ACETAMINOPHEN; Subject Term: SOLVENTS; Subject Term: SILICA; Subject Term: METALWORKING industries; Subject Term: MICHIGAN (N.D.); Subject Term: UNITED States; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schwartz, Joel
AU - Landrigan, Philip J.
AU - Baker Jr., Edward L.
AU - Orenstein, Walter A.
AU - von Lendern, Ian H.
T1 - Lead-Induced Anemia: Dose-Response Relationships and Evidence for a Threshold.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/02//
VL - 80
IS - 2
M3 - Article
SP - 165
EP - 168
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a cross-sectional epidemiologic study to assess the association between blood lead level and hematocrit in 579 one to five year-old children living near a primary lead smelter in 1974. Blood lead levels ranged from 0.53 to 7.91 µ mol/L (11 to 164 µ g/dl). To predict hematocrit as a function of blood lead level and age, we derived non-linear regression models and fit percentile curves. We used logistic regression to predict the probability of hematocrit values < 35 per ¢. We found a strong nonlinear, dose-response relationship between blood lead level and hematocrit. This relationship was influenced by age, but (in this age group) not by sex; the effect was strongest in youngest children. In one year-olds, the age group most severely affected, the risk of an hematocrit value below 35 percent was 2 percent above background at blood lead levels between 0.97 and 1.88 µ mol/L (20 and 39 µ g/dl), 18 percent above background at lead levels of 1.93 to 2.85 µ mol/L (40 to 59 µ g/dl), and 40 percent above background at lead levels of 2.9 µ mol/L (60 µ g/dl) and greater; background was defined as a blood lead level below 1.88 µ mol/L (20 µ g/dl). This effect appeared independent of iron deficiency. These findings suggest that blood lead levels close to the currently recommended limit value of 1.21 µ mol/L (25 µ g/dl) are associated with dose-related depression of hematocrit in young children. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY -- Research
KW - AGE distribution (Demography)
KW - BLOOD diseases
KW - HEMATOCRIT
KW - LOGISTIC regression analysis
KW - GENDER
KW - IRON deficiency diseases
KW - DOSE-response relationship (Biochemistry)
KW - EXAMINATION of the blood
N1 - Accession Number: 4687257; Schwartz, Joel 1 Landrigan, Philip J. 2 Baker Jr., Edward L. 3 Orenstein, Walter A. 4 von Lendern, Ian H. 5; Affiliation: 1: US Environmental Protection Agency, Washington, DC 2: Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029-6574 3: Deputy Director, National Institute for Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia 4: Director, Division of Immunization, Center for Prevention Services, CDC, Atlanta 5: TerraGraphics Environmental Engineering, Moscow, Idaho; Source Info: Feb1990, Vol. 80 Issue 2, p165; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: AGE distribution (Demography); Subject Term: BLOOD diseases; Subject Term: HEMATOCRIT; Subject Term: LOGISTIC regression analysis; Subject Term: GENDER; Subject Term: IRON deficiency diseases; Subject Term: DOSE-response relationship (Biochemistry); Subject Term: EXAMINATION of the blood; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Suzanne M.
AU - Colwell, Lewis S.
AU - Sniezek, Joseph E.
T1 - An Evaluation of External Cause-of-Injury Codes Using Hospital Records from the Indian Health Service, 1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Article
SP - 279
EP - 281
PB - American Public Health Association
SN - 00900036
AB - Abstract: To evaluate the usefulness of International Classification of Diseases external cause-of-injury and poisoning codes (E codes) for public health surveillance of nonfatal injuries, we analyzed E codes from Indian Health Service (IHS) hospital records. E codes for unknown or unspecified causes were used for 25 percent of records. At two hospitals, 63 percent of E codes assigned by independent coders agreed; another 18 percent matched on general cause-of-injury groups. With uniform guidelines and increased training, E coding could provide a valuable, cost-effective method of quantifying and characterizing severe, nonfatal injuries. (Am J Public Health 1990; 80:279-281.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOSOLOGY
KW - PUBLIC health surveillance
KW - WOUNDS & injuries
KW - POISONING
KW - HOSPITAL records
KW - GUIDELINES
KW - TRAINING
KW - COST effectiveness
KW - EPIDEMIOLOGY
N1 - Accession Number: 4691632; Smith, Suzanne M. 1 Colwell, Lewis S. 2 Sniezek, Joseph E. 3; Affiliation: 1: Medical Epidemiologist, Program Surveillence Section, Division of Injury Epidemiology and Control, Center for Environmental Health and Injury Control, Mail Stop F36, Centers for Disease Control, Atlanta, GA 30333 2: Medical Epidemiologist, Division of Injury Epidemiology and Control, CDC, Atlanta 3: Environmental Consultant, Indian Health Services, US Public Health Service, Atlanta; Source Info: Mar1990, Vol. 80 Issue 3, p279; Subject Term: NOSOLOGY; Subject Term: PUBLIC health surveillance; Subject Term: WOUNDS & injuries; Subject Term: POISONING; Subject Term: HOSPITAL records; Subject Term: GUIDELINES; Subject Term: TRAINING; Subject Term: COST effectiveness; Subject Term: EPIDEMIOLOGY; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Newman, Jeffrey M.
AU - Marfin, Anthony A.
AU - Eggers, Paul W.
AU - Helgerson, Steven D.
T1 - End State Renal Disease among Native Americans, 1983-86.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Article
SP - 318
EP - 319
PB - American Public Health Association
SN - 00900036
AB - Abstract: We used data reported to Medicare from 1983 through 1986 to determine the incidence of end-stage renal disease (ESRD) among Native Americans and Whites in the United States. The 1,075 Native American cases represented an annual incidence, ageadjusted to the White population, of 269 per million, 2.8 times the rate for Whites. Fifty-six percent of Native American cases and 27 percent of the White cases were attributed to diabetes, indicating that ESRD is a major problem. Diabetes control provides the greatest opportunity for prevention. (Am J Public Health 1990; 80:318-319.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC kidney failure
KW - NATIVE Americans
KW - CAUCASIAN race
KW - MEDICARE
KW - MEDICAL policy
KW - DIABETES
KW - NATIONAL health insurance
KW - KIDNEY diseases
KW - PUBLIC health
N1 - Accession Number: 4692067; Newman, Jeffrey M. 1 Marfin, Anthony A. 2 Eggers, Paul W. 3 Helgerson, Steven D. 2; Affiliation: 1: Medical Epidemiologist, Division of Diabetes Translation (E08), Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, GA 30333 2: Office of Health PROGRAM Research and Development, Indian Health Service, Tucson, AZ. 3: Office of Research, Health Care Financing Administration, Baltimore, MD.; Source Info: Mar1990, Vol. 80 Issue 3, p318; Subject Term: CHRONIC kidney failure; Subject Term: NATIVE Americans; Subject Term: CAUCASIAN race; Subject Term: MEDICARE; Subject Term: MEDICAL policy; Subject Term: DIABETES; Subject Term: NATIONAL health insurance; Subject Term: KIDNEY diseases; Subject Term: PUBLIC health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Martyny, John
AU - Valway, Sarah
AU - Mangione, Ellen
T1 - Lead Exposure in Indoor Firing Ranges.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/03//
VL - 80
IS - 3
M3 - Letter
SP - 354
EP - 354
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Lead Absorption in Indoor Firing Range Users," by S.E. Valway et al in the August 1989 issue.
KW - LETTERS to the editor
KW - LEAD
N1 - Accession Number: 21088533; Martyny, John 1 Valway, Sarah 1 Mangione, Ellen 1; Affiliation: 1: Indian Health Service Diabetes Program, 2401 12th Street, NW, Albuquerque, NM 87102; Source Info: Mar1990, Vol. 80 Issue 3, p354; Subject Term: LETTERS to the editor; Subject Term: LEAD; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HOLLINGWORTH, THOMAS A.
AU - WEKELL, MARLEEN M.
AU - SULLIVAN, JOHN J.
AU - TORKELSON, JAMES D.
AU - THROM, HAROLD R.
T1 - Chemical Indicators of Decomposition for Raw Surimi and Flaked Artificial Crab.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 1990/03//
VL - 55
IS - 2
M3 - Article
SP - 349
EP - 352
SN - 00221147
AB - BSTRACT Raw surimi and a surimi-derived flaked artificial crab were stored at 4°C, 10°C and 22°C until advanced decomposition occurred. The raw surimi and the flaked artificial crab remained at an acceptable level of quality based on sensory analysis for approximately 2-4 days and 6-8 days, respectively, when stored at 10°C. Both products were of acceptable quality for at least 13 days when stored at 4°C. The potentials of total volatile acids (TVA) and total volatile bases (TVB) determined by flow injection analysis, ethanol determined by head-space gas chromatography and the amines, cadaverine, putrescine, and histamine all determined by high performance liquid chromatography, were evaluated as chemical indicators of decomposition for those products. TVA and TVB appeared to have the most potential as indicators of decomposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DECOMPOSITION (Chemistry)
KW - CRABS
KW - SURIMI
KW - FOOD -- Composition
KW - FOOD -- Analysis
KW - GAS chromatography
KW - AMINES
KW - HISTAMINE
N1 - Accession Number: 63140239; HOLLINGWORTH, THOMAS A. 1 WEKELL, MARLEEN M. 1 SULLIVAN, JOHN J. 2 TORKELSON, JAMES D. 3 THROM, HAROLD R. 3; Affiliation: 1: Authors Hollingworth and Wekell are with the Seafood Products Research Center, Food and Drug Administration, Bothell, WA 98041-3012. 2: Author Sullivan, formerly with the Seafood Products Research Center, is now with Varian Associates, Walnut Creek, CA 94598. 3: Authors Torkelson and Throm are with the Seattle District Laboratory, Food and Drug Administration, Bothell, WA 98041-3012.; Source Info: Mar1990, Vol. 55 Issue 2, p349; Subject Term: DECOMPOSITION (Chemistry); Subject Term: CRABS; Subject Term: SURIMI; Subject Term: FOOD -- Composition; Subject Term: FOOD -- Analysis; Subject Term: GAS chromatography; Subject Term: AMINES; Subject Term: HISTAMINE; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1365-2621.1990.tb06760.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kurt, Thomas L.
AU - Kurt, T L
T1 - The (internal) dangers of acrylic fingernails.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/04/25/
VL - 263
IS - 16
M3 - letter
SP - 2181
EP - 2181
SN - 00987484
AB - Presents a letter to the editor in the April 25, 1990 issue of the 'Journal of the American Medical Association,' about examples of the dangers of acrylic fingernails including cyanide poisoning of children after the ingestion of sculpted nail remover solvents, which contain acetonitrile and other nitriles.
KW - POISONING
KW - CHEMICALS
KW - ACETONITRILE
KW - NITRILES
KW - LETTERS to the editor
KW - COSMETICS
KW - METHEMOGLOBINEMIA
KW - NAILS (Anatomy)
N1 - Accession Number: 11020785; Kurt, Thomas L. 1 Kurt, T L; Affiliation: 1: Food and Drug Administration, Southwest Region; Source Info: 4/25/90, Vol. 263 Issue 16, p2181; Subject Term: POISONING; Subject Term: CHEMICALS; Subject Term: ACETONITRILE; Subject Term: NITRILES; Subject Term: LETTERS to the editor; Subject Term: COSMETICS; Subject Term: METHEMOGLOBINEMIA; Subject Term: NAILS (Anatomy); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 1p; Document Type: letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Kennedy, Dianne L.
AU - Gross, Thomas P.
T1 - Prescribed Use of Cholesterol-Lowering Drugs in the United States, 1978 Through 1988.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1990/04/25/
VL - 263
IS - 16
M3 - Article
SP - 2185
EP - 2188
SN - 00987484
AB - Examines trends in outpatient use of cholesterol-lowering drugs in the U.S. from 1978 through 1988. Estimated prescribed drugs dispensed by retail pharmacies; Introduction of the drugs gemfibrozil and lovastatin; Estimated number of Americans with high cholesterol levels; Top-selling drugs.
KW - ANTICHOLESTEREMIC agents
KW - PHARMACEUTICAL industry
KW - DRUGSTORES
KW - UNITED States
N1 - Accession Number: 11020814; Wysowski, Diane K. 1 Kennedy, Dianne L. 1 Gross, Thomas P. 1; Affiliation: 1: Division of Epidemiology and Surveillance, Office of Epidemiology and Biostatistics, U.S. Food and Drug Administration; Source Info: 4/25/90, Vol. 263 Issue 16, p2185; Subject Term: ANTICHOLESTEREMIC agents; Subject Term: PHARMACEUTICAL industry; Subject Term: DRUGSTORES; Subject Term: UNITED States; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Susten, Allan S.
AU - Breitenstein, Michael J.
T1 - Failure of acrolein to produce sensitization in the guinea pig maximization test.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1990/05//
VL - 22
IS - 5
M3 - Article
SP - 299
EP - 300
SN - 01051873
AB - This article presents information on the study that sought to provide experimental support for acrolein's alleged dermal sensitization properties, by evaluating the ability of acrolein to induce allergic contact dermatitis in an animal model. Dermal sensitization was evaluated in healthy female guinea pigs using the guinea pig maximization test (GPMT). Challenge treatment with acrolein failed to produce positive skin reactions in any of the 15 acrolein-exposed animals or in a similar number of vehicle-treated controls. Sensitization was observed in each of the 15 guinea pigs treated with 1-chloro-2,4-dinitrobenzene.
KW - ACROLEIN
KW - CONTACT dermatitis
KW - GUINEA pigs
KW - ANIMAL models in research
KW - ALLERGY
KW - SKIN -- Inflammation
N1 - Accession Number: 12114790; Susten, Allan S. 1 Breitenstein, Michael J. 1; Affiliation: 1: US Department of Health and Human Services, Public Health Service Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Experimental Toxicology Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA.; Source Info: May90, Vol. 22 Issue 5, p299; Subject Term: ACROLEIN; Subject Term: CONTACT dermatitis; Subject Term: GUINEA pigs; Subject Term: ANIMAL models in research; Subject Term: ALLERGY; Subject Term: SKIN -- Inflammation; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/1600-0536.ep12114790
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Umehara, H.
AU - Bloom, E. T.
T1 - The IL-2 receptor beta subunit is absolutely required for mediating the IL-2-induced activation of NK activity and proliferative activity of human large granular lymphocytes.
JO - Immunology
JF - Immunology
Y1 - 1990/05//
VL - 70
IS - 1
M3 - Article
SP - 111
EP - 115
PB - Wiley-Blackwell
SN - 00192805
AB - TU27 monoclonal antibody reacts with the cellular receptor to the beta subunit of the interleukin-2 receptor (IL-2R) (p70–75). This reagent has been utilized to demonstrate directly that the IL-2Rβ is the IL-2-binding protein that mediates the activation of large granular lymphocytes (LGL) to proliferate and increase cytolytic activity in response to IL-2. The results presented here show that (i) the frequency of TU27+ cells paralleled the frequency of CD16+ (Leu-11+) cells; (ii) TU27 completely abrogated the proliferative response of LGL to IL-2, while GL439, an anti-IL-2Rα (anti-Tac) reagent, had a much smaller effect, and the effect of the two together was no different from the effect of TU27 alone; (iii) TU27 abolished the IL-2-induced activation of natural killer (NK) activity and inhibited the development of LAK activity, while GL439 had no effect; and (iv) TU27 also inhibited naive NK activity. Therefore, these data clearly show that the IL-2-IL-2Rβ interaction is responsible, and probably completely so, for the proliferative and cytolytic-promoting effects of IL-2 on LGL. In addition, they also suggest a role for this interaction in autocrine effects on native NK activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - INTERLEUKIN-2
KW - BIOLOGICAL response modifiers
KW - IMMUNE response -- Regulation
KW - IMMUNOLOGY
N1 - Accession Number: 13356864; Umehara, H. 1,2 Bloom, E. T. 1,2; Affiliation: 1: Geriatric Research, Education and Clinical Center (GRECC), VA Medical Center West Los Angeles, UCLA Department of Medicine, Los Angeles, California 2: Division of Cytokine Biology, Center for Biologics Evaluation and research, Food and Drug, Administration, Bethesda, Maryland, U.S.A.; Source Info: May90, Vol. 70 Issue 1, p111; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: INTERLEUKIN-2; Subject Term: BIOLOGICAL response modifiers; Subject Term: IMMUNE response -- Regulation; Subject Term: IMMUNOLOGY; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, N. Kyle
AU - Silverman, Debra T.
AU - Hornung, Richard W.
T1 - Case-Control Study of Lung Cancer and Truck Driving in the Teamsters Union.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/06//
VL - 80
IS - 6
M3 - Article
SP - 670
EP - 674
PB - American Public Health Association
SN - 00900036
AB - Abstract: We conducted a case-control study of lung cancer deaths in the Teamsters Union to compare the risk of different occupations within the teamsters, after controlling for smoking and other confounders. Occupations with no presumed exposure to diesel fumes were used as the nonexposed group. The study population consisted of 996 cases and 1,085 controls who had died in 1982-83 after applying for pensions. Next of kin provided information on smoking, work history, and other potential confounders. Work history data were also obtained from the Teamsters Union. While no single job category had a significant excess risk compared to the non-exposed group, certain sub-groups were elevated. The odds ratio for those with long-term employment as long-haul truckers after 1959 (an approximate date for the introduction of diesel engines) was 1.55 (95% CI: 0.97, 2.47). Long-term drivers of primarily diesel trucks had an odds ratio of 1.89 (95% CI: 1.04, 3.42). Overall, our results suggest that diesel truck drivers have an excess risk of lung cancer compared to other teamsters in jobs outside the trucking industry. However, our findings were not uniformly consistent and our data have many limitations, the most important of which is the lack of data on exposure to diesel fumes. (Am J Public Health 1990; 80:670-674.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Cancer
KW - TRANSPORT workers
KW - SMOKING
KW - DIESEL motor exhaust gas
KW - PENSIONS
KW - OCCUPATIONAL diseases
KW - PUBLIC health
KW - INTERNATIONAL Brotherhood of Teamsters
N1 - Accession Number: 4684898; Steenland, N. Kyle 1 Silverman, Debra T. 2 Hornung, Richard W. 1; Affiliation: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Robert A. Taft Laboratories. 4676 Columbia Parkway. Cincinnati, OH 2: National Cancer Institute; Source Info: Jun90, Vol. 80 Issue 6, p670; Subject Term: LUNGS -- Cancer; Subject Term: TRANSPORT workers; Subject Term: SMOKING; Subject Term: DIESEL motor exhaust gas; Subject Term: PENSIONS; Subject Term: OCCUPATIONAL diseases; Subject Term: PUBLIC health; Company/Entity: INTERNATIONAL Brotherhood of Teamsters; NAICS/Industry Codes: 526111 Trusteed pension funds; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, Roberta L.
AU - Wilder, Doni
AU - Bodenroeder, Pamela
AU - Hess, Michael
T1 - Assessment of AIDS Knowledge, Attitudes, Behaviors, and Risk Level of Northwestern American Indians.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/07//
VL - 80
IS - 7
M3 - Article
SP - 875
EP - 877
PB - American Public Health Association
SN - 00900036
AB - A survey was made of 710 American Indians of Oregon, Washington, and Idaho to assess the population's knowledge, attitudes, and behaviors in respect to acquired immunodeficiency syndrome (AIDS), to estimate the population's risk, and to plan strategies to reduce it. In contrast to 3 percent of the general population, this study found 10.6 percent of male and 6.4 percent of female Pacific Northwestern American Indians in groups considered at high risk for AIDS. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - HEALTH behavior
KW - ATTITUDES toward health
KW - HEALTH risk assessment
KW - NATIVE Americans
KW - OREGON
KW - WASHINGTON (State)
KW - IDAHO
KW - UNITED States
N1 - Accession Number: 9102111383; Hall, Roberta L. 1 Wilder, Doni 2 Bodenroeder, Pamela 3 Hess, Michael 4; Affiliation: 1: Professor, Department of Anthropology, Oregon State University, Waldo Hall 238, Corvallis, OR 97331-6403 2: NW Portland Area Indian Health Board 3: Survey Research Center, Oregon State University, Corvallis 4: Indian Health Service, Portland; Source Info: Jul1990, Vol. 80 Issue 7, p875; Subject Term: AIDS (Disease); Subject Term: HEALTH behavior; Subject Term: ATTITUDES toward health; Subject Term: HEALTH risk assessment; Subject Term: NATIVE Americans; Subject Term: OREGON; Subject Term: WASHINGTON (State); Subject Term: IDAHO; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Puri, R.K.
AU - Finbloom, D.S.
AU - Leland, P.
AU - Mostowski, H.
AU - Siegel, J.P.
T1 - Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2.
JO - Immunology
JF - Immunology
Y1 - 1990/08//
VL - 70
IS - 4
M3 - Article
SP - 492
EP - 497
PB - Wiley-Blackwell
SN - 00192805
AB - Since interleukin-2 (IL-2) and IL-4 act in concert to support the development of cytotoxic T lymphocytes (CTL) and the generation of antigen-specific tumour infiltrating lymphocytes (TIL), we investigated the interaction of these cytokines with an established TIL line. TIL proliferated in an additive fashion in response to suboptimal concentrations of IL-2 and various concentrations of IL-4. TIL possessed high-affinity IL-4 receptors whether cultured in recombinant IL-2 (rIL-2) or rIL-4, but cells cultured in rIL-2 had higher numbers of IL-4 receptors than cells cultured in rIL-4. When TIL were cultured in increasing concentrations of rIL-2, a dose-dependent enhancement in IL4 receptor number was observed. The maximum induction of IL-4 receptor expression was achieved by 4 hr of incubation with rIL-2 and was completely blocked by cycloheximide. Other cytokines, such as rIL-1, recombinant turnout necrosis factor (rTNF), recombinant interferon-alpha (rIFN-α) and rIFN-γ, had no effect on IL-4 receptor number, rIL-2 also up-regulated IL-4 receptors on CTLL-2, a murine CTL line. These data indicate that high-affinity IL-4 receptors exist on murine TIL and they can be up-regulated by IL-2. Our observation that IL-2 up-regulates IL-4 receptor may help explain the additive effects of these lymphokines on the proliferation of TI L and other cell lines. It may also help explain their co-operative effects on the generation of antigen-specific TIL and the differentiation of CTL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - TUMORS
KW - INTERLEUKIN-2
KW - CYTOKINES
KW - CELL receptors
KW - LYMPHOKINES
N1 - Accession Number: 13383273; Puri, R.K. 1 Finbloom, D.S. 1 Leland, P. 1 Mostowski, H. 1 Siegel, J.P. 1; Affiliation: 1: Division of Cytokine Biologyy, Center for Biologics Evaluation and Research, FDA, USA; Source Info: Aug90, Vol. 70 Issue 4, p492; Subject Term: LYMPHOCYTES; Subject Term: TUMORS; Subject Term: INTERLEUKIN-2; Subject Term: CYTOKINES; Subject Term: CELL receptors; Subject Term: LYMPHOKINES; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shaw Jr., Frederic E.
AU - Shapiro, Craig N.
AU - Welty, Thomas K.
AU - Dill, William
AU - Reddington, Jay
AU - Hadler, Stephen C.
T1 - Hepatitis Transmission Among the Sioux Indians of South Dakota.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/09//
VL - 80
IS - 9
M3 - Article
SP - 1091
EP - 1094
PB - American Public Health Association
SN - 00900036
AB - Hepatitis A continues to occur in cyclical community-wide epidemics on the Indian reservations of South Dakota. In June 1985 a population-based serosurvey for viral hepatitis involving 120 households was conducted at the Pine Ridge and Rosebud Sioux Indian reservations in South Dakota. The serosurvey was performed shortly after a large hepatitis A epidemic on the Pine Ridge reservation in 1983-44, and immediately before a large hepatitis A epidemic on the Rosebud reservation in 1985-86. The overall seroprevalence for antibodies to hepatitis A virus (anti-HAV) was 76.2 percent (Pine Ridge reservation 80.5 percent, Rosebud reservation 72.0 percent, relative risk = 1.12, 95 percent confidence interval = 1.01, 1.24). For age groups 0 to 4 years, 54.2 percent and 36.1 percent of children were seropositive at Pine Ridge and Rosebud, respectively. Seropositivity rose rapidly with age by age 40, more than 90 percent of persons at both Pine Ridge and Rosebud were anti-HAV positives. Only 1.1 percent of persons tested were positive for hepatitis B markers, Anti-HAV seroprevalence rates in both communities are similar to rates observed in developing countries. The surprisingly high anti-HAV seroprevalence among young children at Rosebud, where clinical hepatitis A had been virtually absent in the previous seven years, indicates that high-grade silent transmission was taking place during the interepidemic period. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A
KW - ENTEROVIRUS diseases
KW - VIRAL hepatitis
KW - EPIDEMICS
KW - NATIVE Americans -- Reservations
KW - HEPATITIS
KW - COMMUNICABLE diseases
KW - INFLAMMATION
KW - LIVER diseases
KW - SOUTH Dakota
N1 - Accession Number: 9101281034; Shaw Jr., Frederic E. 1 Shapiro, Craig N. 1 Welty, Thomas K. 2 Dill, William 2 Reddington, Jay 1 Hadler, Stephen C. 1; Affiliation: 1: Hepatitis Branch, Division of Viral and Rickettsial Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, GA 2: Aberdeen Area Indian Health Service, Public Health Service Indian Hospital, Rapid City, SD; Source Info: Sept90, Vol. 80 Issue 9, p1091; Subject Term: HEPATITIS A; Subject Term: ENTEROVIRUS diseases; Subject Term: VIRAL hepatitis; Subject Term: EPIDEMICS; Subject Term: NATIVE Americans -- Reservations; Subject Term: HEPATITIS; Subject Term: COMMUNICABLE diseases; Subject Term: INFLAMMATION; Subject Term: LIVER diseases; Subject Term: SOUTH Dakota; Number of Pages: 4p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fotos, Pete G.
AU - Lewis, Daniel M.
AU - Gerencser, Vincent F.
AU - Gerencser, Mary Ann
T1 - Cytotoxic and immunostimulatory effects of Bacteroides cell products.
JO - Journal of Oral Pathology & Medicine
JF - Journal of Oral Pathology & Medicine
Y1 - 1990/09//
VL - 19
IS - 8
M3 - Article
SP - 360
EP - 366
SN - 09042512
AB - The etiologic role of Bacteroides in both periodontal and periapical infections has been well documented, with current interest focusing on the specific pathogenic mechanism involved. The effects of cell fractions derived from Bacteriodes gingivalis (BG), Bacteriodes intermedius (BI), and Bacteriodes asaccharolyticus (BA) have been studied in vivo through: an assessment of the direct cytotoxic effects on human gingival fibroblasts using a tetrzolium dye reduction assay, an evaluation of murine lymphocyte stimulation and interleukin-1 release, and the induction of human lymphocyte-mediated cytotoxicity. Both BG and BI stimulated interleukin-1 release (P<0.001), while BA, a nonoral organism, was not significantly active in this respect. Only BG sonicates were able to induce lymphocyte-mediated cytotoxicity (P<0.05). All three Bacteriodes species demonstrated direct cytotoxic effects on cultured gingival fibroblasts, and these effects were related to the relative protein content and endotoxin activity of the sonicate preparations for each program. These data show that BG and BI possess factors which may enhance their virulence through activities not shared with BA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTEROIDES
KW - PERIAPICAL diseases
KW - CELL-mediated cytotoxicity
KW - LYMPHOCYTES
KW - INTERLEUKIN-1
KW - Bacteroides
KW - lymphocytes
KW - sonicate
KW - toxicity
KW - virulence
N1 - Accession Number: 11481332; Fotos, Pete G. 1 Lewis, Daniel M. 2 Gerencser, Vincent F. 3 Gerencser, Mary Ann 3; Affiliation: 1: Departments of Oral Pathology and Diagnosis, College of Dentistry, University of Iowa 2: National Institute of Occupational Safety and Health 3: Medical Microbiology and Immunology, West Virginia University Health Sciences Center, USA; Source Info: Sep1990, Vol. 19 Issue 8, p360; Subject Term: BACTEROIDES; Subject Term: PERIAPICAL diseases; Subject Term: CELL-mediated cytotoxicity; Subject Term: LYMPHOCYTES; Subject Term: INTERLEUKIN-1; Author-Supplied Keyword: Bacteroides; Author-Supplied Keyword: lymphocytes; Author-Supplied Keyword: sonicate; Author-Supplied Keyword: toxicity; Author-Supplied Keyword: virulence; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1600-0714.ep11481332
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pappas, Gregory
AU - Gergen, Peter J.
AU - Carroll, Margaret
T1 - Hypertension Prevalence and the Status of Awareness, Treatment, and Control in the Hispanic: Findings from HHANES 1982-84.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1990/12//
VL - 80
IS - 12
M3 - Article
SP - 1431
EP - 1437
PB - American Public Health Association
SN - 00900036
AB - The prevalence rates of hypertension among adult (ages 18-74) Mexican Americans, Cuban Americans, and Puerto Ricans were estimated using data from the 1982-84 Hispanic Health and Nutrition Examination Survey (HHANES). Hypertension is defined as diastolic greater than or equal to 90 mm Hg, or systolic greater than or equal to 140 mm Hg, or currently taking antihypertensive medication. Among Mexican Americans in the Southwestern United States, 16.8 percent of the males and 14.1 percent or the females were found to he hypertensive, Among Cuban Americans in Dade County, Florida 22.8 percent of the males and 15.5 percent of the females were hypertensive. Among Puerto Ricans in the New York City area 15.6 percent of the mates and 11.5 percent of the females were hypertensive. The age-adjusted rates are significantly lower than comparable rates for Whites and Blacks as measured in the second National Health and Nutrition Examination Survey (NHANES II), 1976-80. Control of hypertension in the HHANES populations fall short of the 1990 Objectives for the Nation established by the US Public Health Service 60 percent (34 percent controlled Mexican American hypertensives, 27.8 percent controlled Cuban American hypertensives, and 29 percent controlled Puerto Rican hypertensives). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTENSION
KW - BLOOD circulation disorders
KW - CARDIOVASCULAR diseases
KW - HISPANIC Americans
KW - LATIN Americans -- United States
KW - MEXICAN Americans
KW - CUBAN Americans
KW - PUERTO Ricans
KW - PUBLIC health
N1 - Accession Number: 9012241105; Pappas, Gregory 1 Gergen, Peter J. 1 Carroll, Margaret 1; Affiliation: 1: National Center for Health Statistics, Dept. of Health & Human Services, US Public Health Service; Source Info: Dec1990, Vol. 80 Issue 12, p1431; Subject Term: HYPERTENSION; Subject Term: BLOOD circulation disorders; Subject Term: CARDIOVASCULAR diseases; Subject Term: HISPANIC Americans; Subject Term: LATIN Americans -- United States; Subject Term: MEXICAN Americans; Subject Term: CUBAN Americans; Subject Term: PUERTO Ricans; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sterritt, Gene R.
AU - Frew, Ralph A.
AU - Rozier, R. Gary
AU - Brunelle, Janet A.
T1 - Evaluation of a school-based fluoride mouthrinsing and clinic-based sealant program on a non-fluoridated island.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 1990/12//
VL - 18
IS - 6
M3 - Article
SP - 288
EP - 293
SN - 03015661
AB - For many years the children of Guam have experienced a high prevalence of dental caries. Surveys conducted on the fluoride-deficient island found that caries levels were double those of US mainland children. In 1976 a school-based fluoride mouthrinse program was initiated involving over 22000 children in grades kindergarten through eight in weekly rinses with 0.2% neutral NaF. A clinic-based dental pit and fissure sealant program was added in 1984 to the fluoride mouthrinse program. Over 15000 children participated annually in the sealant program where more than 75000 teeth were sealed the first year. After 8 yr of fluoride mouthrinsing (1976-1984) mean DMFS scores were 1.79 surfaces per child lower compared to baseline, a decrease of 0.22 DMFS per child per year. During this period proximal DMFS scores decreased 61%, buccal-lingual surfaces 31%, and occlusal surfaces 7%. After 2 yr of fluoride mouthrinsing and sealant application combined overall DMFS scores decreased an additional 2.34 surfaces per child, a reduction of 1.17 DMFS per child per year. Most of this decline took place on pit and fissure surfaces. For the 10-yr period a reduction of 4.13 DMFS per child was seen - a decline from 7.06 DMF at baseline to 2.93 DMF surfaces per child in 1986. This long-term evaluation indicates that dental sealants when used in combination with fluoride mouthrinse were particularly effective in lowering the prevalence of dental caries. Schoolchildren in participating grades on Guam now have dental caries rates close to those of US schoolchildren. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries -- Prevention
KW - PREVENTIVE dentistry
KW - DENTAL pathology
KW - CHILDREN
KW - SEALING compounds
KW - MEDICAL care
KW - clinic-based sealant program
KW - dental caries prevention
KW - fluoride-deficient island
KW - school-based fluoride mouthrinse programs
N1 - Accession Number: 12030370; Sterritt, Gene R. 1 Frew, Ralph A. 2 Rozier, R. Gary 3 Brunelle, Janet A. 4; Affiliation: 1: US Public Health Service, Region VP/Suite 1800, Dallas, Texas, USA. 2: Dept. of Public Health & Social Services, Government of Guam, Agana, Guam. 3: School of Public Health, University of North Carolina, Chapel Hill, North Carolina. 4: Epidemiology Branch/EODPP/NIDR, Bethesda, Maryland, USA.; Source Info: Dec1990, Vol. 18 Issue 6, p288; Subject Term: DENTAL caries -- Prevention; Subject Term: PREVENTIVE dentistry; Subject Term: DENTAL pathology; Subject Term: CHILDREN; Subject Term: SEALING compounds; Subject Term: MEDICAL care; Author-Supplied Keyword: clinic-based sealant program; Author-Supplied Keyword: dental caries prevention; Author-Supplied Keyword: fluoride-deficient island; Author-Supplied Keyword: school-based fluoride mouthrinse programs; NAICS/Industry Codes: 325520 Adhesive Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0528.ep12030370
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12030370&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Mason, James O.
T1 - Preventing injuries.
JO - Issues in Science & Technology
JF - Issues in Science & Technology
Y1 - 1990///Winter90/91
VL - 7
IS - 2
M3 - Letter
SP - 23
EP - 24
PB - University of Texas at Dallas
SN - 07485492
AB - Presents a letter to the editor in response to the article "Not by Accident," by Ilana Lescohier, Susan S. Gallagher and Bernard Guyer.
KW - LETTERS to the editor
KW - WORK-related injuries
N1 - Accession Number: 13540597; Mason, James O. 1; Affiliation: 1: Public Health Service, U.S. Department of Health and Human Services; Source Info: Winter90/91, Vol. 7 Issue 2, p23; Subject Term: LETTERS to the editor; Subject Term: WORK-related injuries; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Goodwin, Frederick K.
T1 - Pro and con on animal research.
JO - Issues in Science & Technology
JF - Issues in Science & Technology
Y1 - 1990///Winter90/91
VL - 7
IS - 2
M3 - Letter
SP - 28
EP - 28
PB - University of Texas at Dallas
SN - 07485492
AB - Presents a letter to the editor in response to the article "Responding to the Animal Activists," by Jerod M. Loeb and Deborah C. Runkle in the Summer 1990 issues.
KW - LETTERS to the editor
KW - LABORATORY animals
N1 - Accession Number: 13544674; Goodwin, Frederick K. 1; Affiliation: 1: Alcohol, Drug Abuse and Mental Health Administration, Public Health Service, U.S. Department of Health and Human Services; Source Info: Winter90/91, Vol. 7 Issue 2, p28; Subject Term: LETTERS to the editor; Subject Term: LABORATORY animals; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gerstman, B. Burt
AU - Gross, Thomas P.
AU - Kennedy, Dianne L.
AU - Bennett, Ridgely C.
AU - Tomita, Dianne K.
AU - Stadel, Bruce V.
T1 - Trends in the Content and Use of Oral Contraceptives in the United States, 1964-88.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/01//
VL - 81
IS - 1
M3 - Article
SP - 90
EP - 96
PB - American Public Health Association
SN - 00900036
AB - Drug marketing and physician survey data were used to examine trends in the use and hormonal content of oral contraceptives in the United States between 1964 and 1988. Retail prescriptions for oral contraceptives peaked at approximately 68 million in 1973 and have remained between 50 million and 60 million since 1981. Despite this relative consistency in the number of prescriptions, physician "mentions" of oral contraceptives have increased by approximately 75 percent. This increase may reflect closer monitoring of women on oral contraceptives. Use of multiphasic formulations has steadily risen, accounting for 37 percent of the oral contraceptive prescriptions in 1988. Mean estrogen and progestin doses in all types of formulations have steadily declined. A change in the type of estrogen and progestin used in preparations has coincided with this decline in dose. The association between age and use of high-dose formulations seen in the past was no longer evident in 1988. The data demonstrate that oral contraceptive formulations in wide use today differ in hormone content from those of the past, when most of the major studies addressing the risks associated with oral contraceptive use were completed. There is therefore a need to determine the risks and long-term effects associated with these newer formulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTRACEPTIVE drugs
KW - ORAL contraceptives
KW - DRUGS -- Marketing
KW - PRESCRIPTION of drugs
KW - ESTROGEN
KW - PROGESTATIONAL hormones
KW - SURVEYS
KW - DRUGS
KW - UNITED States
N1 - Accession Number: 9103182520; Gerstman, B. Burt 1 Gross, Thomas P. 1 Kennedy, Dianne L. 1 Bennett, Ridgely C. 1 Tomita, Dianne K. 1 Stadel, Bruce V. 2; Affiliation: 1: Office of Epidemiology and Biostatistics, HFD-733, Food and Drug Administration, Rockville, MD 20857 2: Division of Endocrine and Metabolic Drug Products, Rockville, MD 20857; Source Info: Jan1991, Vol. 81 Issue 1, p90; Subject Term: CONTRACEPTIVE drugs; Subject Term: ORAL contraceptives; Subject Term: DRUGS -- Marketing; Subject Term: PRESCRIPTION of drugs; Subject Term: ESTROGEN; Subject Term: PROGESTATIONAL hormones; Subject Term: SURVEYS; Subject Term: DRUGS; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Puri, R. K.
AU - Leland, P.
AU - Razzaque, A.
T1 - Antigen(s)-specific tumour-infiltrating lymphocytes from tumour induced by human herpes virus-6 (HHV-6) DNA transfected NIH 3T3 transformants.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1991/01//
VL - 83
IS - 1
M3 - Article
SP - 96
EP - 101
PB - Wiley-Blackwell
SN - 00099104
AB - Tumour infiltrating lymphocytes (TIL) have recently been shown to mediate potent therapeutic effects in certain malignancies in mice and in humans. To understand the mechanism of TIL immunotherapy it would be advantageous to generate tumour-specific TIL and to study a defined system of TIL and target cells in which the tumour epitope(s) recognized by TIL might be identified. We have established tumourigenic cell lines by transfection of NIH 3T3 cells with the entire genome of human herpesvirus-6 (HHV-6) and its small fragment (about 5% of the viral DNA sequence). Injection of these cells into nude mice produced tumours termed G-2T and 14-2T, respectively. Cell lines derived from these tumours when injected in NIH Swiss mice produced tumours, G-2TS and 14-2TS, respectively. We have generated TIL from G-2TS tumour that can kill G-2TS tumour cells in vitro but not other related tumours (14-2TS or MCA-106). These TIL can be expanded between 2-6.5 every 3-5 days. The TIL proliferated in tissue culture in response to recombinant interleukin-2 and interleukin-4 and maintained their tumour specificity for up to 6 months in vitro. Their phenotype was Thy 1.2+, Lyt-2+ and L3T4- . The availability of such tumour-specific stable TIL lines and specific viral-transformed targets will provide an opportunity to characterize the tumour-associated antigen critical for the specific cytotoxicity in this system and thereby lo clarify the mechanism of this promising immunological approach to cancer therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - LYMPHOCYTES
KW - IMMUNOTHERAPY
KW - NUCLEOTIDE sequence
KW - HUMAN herpesvirus-6
KW - CANCER treatment
KW - GENETIC transformation
KW - tumour-infiltrating lymphocytes cancer immunotherapy HHV-6 interleukin-2
N1 - Accession Number: 15988006; Puri, R. K. 1 Leland, P. 1 Razzaque, A. 2; Affiliation: 1: Divisions of Cytokine Biology, Bethesda, MD, USA. 2: Virology, Center For Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.; Source Info: Jan1991, Vol. 83 Issue 1, p96; Subject Term: ANTIGENS; Subject Term: LYMPHOCYTES; Subject Term: IMMUNOTHERAPY; Subject Term: NUCLEOTIDE sequence; Subject Term: HUMAN herpesvirus-6; Subject Term: CANCER treatment; Subject Term: GENETIC transformation; Author-Supplied Keyword: tumour-infiltrating lymphocytes cancer immunotherapy HHV-6 interleukin-2; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Black, C. M.
AU - McDougal, J. S.
AU - Evatt, B. L.
AU - Reimer, C. B.
T1 - Human markers for IgG2 and IgG4 appear to be on the same molecule in the chimpanzee.
JO - Immunology
JF - Immunology
Y1 - 1991/01//
VL - 72
IS - 1
M3 - Article
SP - 94
EP - 98
PB - Wiley-Blackwell
SN - 00192805
AB - It has been reported that all four immunoglobulin G (IgG) subclasses present in human serum are also present in chimpanzee serum, as detected with antibodies specific for the human IgG subclasses. We used monoclonal antibodies (mAb) specific for human IgG subclasses to measure concentrations of thc four subclasses in chimpanzee sera. Initial ELISA studies indicated that epitopes for all four human subclasses are present in chimpanzee sera. The concentrations of IgG1, IgG2 and IgG3 were similar in human and chimpanzee sera, but the registered concentrations of IgG4 were different. Absorption of IgG2-reactive material from chimpanzee serum with IgG2 mAb resulted in removal of IgG4-reactive material as well. Conversely, absorption of IgG4-reactive material removed IgG2reactive material, IgG2-reactive material, isolated from chimpanzee serum using solid-phase antiIgG2 mAb, reacted with anti-IgG4 mAb, and isolated IgG4-reactive material reacted with anti-IgG2 mAb. Three anti-IgG2 mAb and five anti-IgG4 mAb, each of which react with separate epitopes on their respective human isotype, were used in these studies. We conclude that chimpanzee serum contains only three IgG isotypes related to those of humans, one of which contains determinants related to both human IgG2 and IgG4. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN G
KW - MONOCLONAL antibodies
KW - ENZYME-linked immunosorbent assay
KW - CHIMPANZEES as laboratory animals
KW - IMMUNOLOGY -- Animal models
N1 - Accession Number: 13385576; Black, C. M. 1 McDougal, J. S. 1 Evatt, B. L. 1 Reimer, C. B.; Affiliation: 1: Division of Immunologic, Oncologic and Hematologic Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, U.S.A.; Source Info: Jan1991, Vol. 72 Issue 1, p94; Subject Term: IMMUNOGLOBULIN G; Subject Term: MONOCLONAL antibodies; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: CHIMPANZEES as laboratory animals; Subject Term: IMMUNOLOGY -- Animal models; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prescott, Patricia A.
T1 - Forecasting Requirements for Health Care Personnel.
JO - Nursing Economic$
JF - Nursing Economic$
Y1 - 1991/01//Jan/Feb91
VL - 9
IS - 1
M3 - Article
SP - 18
EP - 24
PB - Jannetti Publications, Inc.
SN - 07461739
AB - The article focuses on the forecasting requirements for health care personnel. Health care spending in the U.S. is the largest in the world in both absolute and relative terms and continues to grow despite cost-containment efforts. This study highlights some of the complexities associated with forecasting requirements for health care personnel by first identifying the major previous approaches to manpower forecasting. From a review of five general approaches, analytic components for a comprehensive model are suggested and discussed regarding their importance for understanding disequilibrium, particularly shortages, in the providers of health care services.
KW - MEDICAL personnel
KW - MEDICAL care
KW - FORECASTING
KW - SPECIFICATIONS
KW - MANPOWER
KW - UNITED States
N1 - Accession Number: 12175931; Prescott, Patricia A. 1; Affiliation: 1: Advisor, Agency for Health Care Policy and Research, Public Health Service, Department of Health and Human Services.; Source Info: Jan/Feb91, Vol. 9 Issue 1, p18; Subject Term: MEDICAL personnel; Subject Term: MEDICAL care; Subject Term: FORECASTING; Subject Term: SPECIFICATIONS; Subject Term: MANPOWER; Subject Term: UNITED States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Conner, Dale P.
AU - Millora, Emily
AU - Zamani, Kaveh
AU - Nix, Darrell
AU - Almirez, Ramona G.
AU - Rhyne-Kirsch, Patricia
AU - Peck, Carl C.
T1 - Transcutaneous Chemical Collection of Caffeine in Normal Subjects: Relationship to Area Under the Plasma Concentration-Time Curve and Sweat Production.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1991/02//
VL - 96
IS - 2
M3 - Article
SP - 186
EP - 190
SN - 0022202X
AB - A novel transcutaneous chemical collection device (TCD) has been developed to study the phenomenon of outward transcutaneous chemical migration. The TCD is a Bandaid-like device containing an immobilized aqueous media and binding reservoir material to prevent back-transfer into the skin. This device, when placed against the skin, allows collection and quantitation of chemicals that diffuse directly through the skin from within the body. The relationship of the amount of drug collected in the TCD to the amount in the body available for collection (as represented by the area under the plasma-concentration time curve, AUC) and the effects of sweating, a potential confounding factor, on collection of drug in a TCD were studied, using caffeine as a model compound. TCD were placed on the skin of normal male volunteers. Twenty-four hours later subjects took caffeine by mouth. Blood samples were collected and TCD were removed at various times after drug intake and analyzed by HPLC for caffeine. Studies of the sweating effect were carried out in a similar manner, except that one arm of each subject was maintained at 40°C to induce local sweating, the other arm acted as a non-sweating control. The amount of caffeine collected was linearly related to the AUC. Sweating seemed to have a large (40%) contribution to transdermal collection in the early period (5.5 h) of the study, but this difference was much less (14%) at longer collection times (10 h). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - CAFFEINE
KW - SWEAT glands -- Diseases
KW - DERMATOLOGY
KW - DRUGS
KW - ANALYTICAL chemistry
N1 - Accession Number: 12461011; Conner, Dale P. 1 Millora, Emily 1 Zamani, Kaveh 1 Nix, Darrell 1 Almirez, Ramona G. 1 Rhyne-Kirsch, Patricia 1 Peck, Carl C. 2; Affiliation: 1: Division of Clinical Pharmacology , Departments of Pharmacology and Medicine, Uniformed Services University of the Health Sciences, Bethesda 2: Center for Drug Evaluation and Research , Food and Drug Administration, Rockville, Maryland, U.S.A.; Source Info: Feb91, Vol. 96 Issue 2, p186; Subject Term: SKIN diseases; Subject Term: CAFFEINE; Subject Term: SWEAT glands -- Diseases; Subject Term: DERMATOLOGY; Subject Term: DRUGS; Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12461011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Novello, Antonia C.
AU - Wise, Paul H.
AU - Kleinman, Dushanka V.
AU - Orenstein, Walter A.
AU - Sepe, Stephen I.
AU - Novello, A C
AU - Wise, P H
AU - Kleinman, D V
AU - Orenstein, W A
AU - Sepe, S I
T1 - From the Surgeon General, US Public Health Service.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/03/20/
VL - 265
IS - 11
M3 - journal article
SP - 1364
EP - 1364
SN - 00987484
AB - Reflects on the efforts of the U.S. medical community to meet the first goal of the National Education Summit that children will receive the nutrition and care needed to arrive at school with healthy minds and bodies. Primary care services for children; Immunization; Challenges posed by the objective.
KW - CHILD nutrition -- Psychological aspects
KW - CHILD care
KW - CHILDREN -- Health
KW - EDUCATION -- United States
KW - UNITED States
N1 - Accession Number: 10415747; Novello, Antonia C. Wise, Paul H. Kleinman, Dushanka V. Orenstein, Walter A. Sepe, Stephen I. Novello, A C 1 Wise, P H Kleinman, D V Orenstein, W A Sepe, S I; Affiliation: 1: Office of the Surgeon General, Washington, DC 20201; Source Info: 3/20/91, Vol. 265 Issue 11, p1364; Subject Term: CHILD nutrition -- Psychological aspects; Subject Term: CHILD care; Subject Term: CHILDREN -- Health; Subject Term: EDUCATION -- United States; Subject Term: UNITED States; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mason, James O.
AU - Mason, J O
T1 - From the Assistant Secretary for Health, US Public Health Service.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/04/24/
VL - 265
IS - 16
M3 - journal article
SP - 2049
EP - 2049
SN - 00987484
AB - Discusses the plan of the U.S. Public Health Service to eliminate childhood lead poisoning in the U.S. Prevalence of lead poisoning among children in the U.S.; Source of lead poisoning in children; Features of the plan of the U.S. Public Health Service.
KW - LEAD poisoning in children
KW - PUBLIC health -- United States
KW - JUVENILE diseases
KW - LEAD poisoning -- Prevention
KW - HEALTH promotion
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 10338442; Mason, James O. Mason, J O 1; Affiliation: 1: DHHS Assistant Secretary for Health, Public Health Service; Source Info: 4/24/91, Vol. 265 Issue 16, p2049; Subject Term: LEAD poisoning in children; Subject Term: PUBLIC health -- United States; Subject Term: JUVENILE diseases; Subject Term: LEAD poisoning -- Prevention; Subject Term: HEALTH promotion; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Carroll, Patrick W.
AU - Loftin, Colin
AU - Waller Jr., John B.
AU - McDowall, David
AU - Bukoff, Allen
AU - Scott, Richard O.
AU - Mercy, James A.
AU - Wiersema, Brian
T1 - Preventing Homicide: An Evaluation of the Efficacy of a Detroit Gun Ordinance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/05//
VL - 81
IS - 5
M3 - Article
SP - 576
EP - 581
PB - American Public Health Association
SN - 00900036
AB - Background: In November 1986, a Detroit, Michigan city ordinance requiring mandatory jail sentences for illegally carrying a firearm in public was passed to preserve "the public peace, health, safety, and welfare of the people." Methods: We conducted a set of interrupted lime-series analyses to evaluate the impact of the law on the incidence of homicide, hypothesizing that the ordinance, by its nature, would affect only firearm homicides and homicides committed outside (e.g., on the street). Results: The incidence of homicide in general increased after the law was passed, but the increases in non-firearm homicides and homicides committed inside (e.g., in a home) were either statistically significant or approached statistical significance (p = .(X)6 and p = .070, respectively), whereas changes in the incidence of firearm homicides and homicides committed outside were not statistically significant (p = .238 and p = .418, respectively). We also determined that the ordinance was essentially unenforced, apparently because of a critical shortage of jail space. Conclusions: Our findings are consistent with a model in which the ordinance had a dampening effect on firearm homicides occurring in public in Detroit. The apparent preventive effect evident in the time series analyses may have been due to publicity about the ordinance, whereas the small nature of the effect may have been due to the lack of enforcement. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMICIDE
KW - MUNICIPAL ordinances
KW - FIREARMS -- Law & legislation
KW - PUBLIC health
KW - GUN control
KW - PUBLIC welfare
KW - CRIMINAL law
KW - DETROIT (Mich.)
KW - MICHIGAN
N1 - Accession Number: 9107081083; O'Carroll, Patrick W. 1 Loftin, Colin 2 Waller Jr., John B. 3 McDowall, David 4 Bukoff, Allen 3 Scott, Richard O. 3 Mercy, James A. 1 Wiersema, Brian 2; Affiliation: 1: Division of Injury Control, Center for Environmental Health and Injury Control, Centers for Disease Control, US Public Health Service, Atlanta, GA 2: Institute of Criminal Justice and Criminology, University of Maryland, College Park, MD 3: Center for Prevention and Control of Interpersonal Violence, Department of Community Medicine, Wayne State University School of Medicine, Detroit, MI 4: School of Criminal Justice, State University of New York, Albany, NY.; Source Info: May91, Vol. 81 Issue 5, p576; Subject Term: HOMICIDE; Subject Term: MUNICIPAL ordinances; Subject Term: FIREARMS -- Law & legislation; Subject Term: PUBLIC health; Subject Term: GUN control; Subject Term: PUBLIC welfare; Subject Term: CRIMINAL law; Subject Term: DETROIT (Mich.); Subject Term: MICHIGAN; NAICS/Industry Codes: 451119 All other sporting goods stores; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 332992 Small Arms Ammunition Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thun, Michael J.
AU - Schober, Susan
T1 - Urolithiasis in Tennessee: An Occupational Window Into a Regional Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/05//
VL - 81
IS - 5
M3 - Article
SP - 587
EP - 591
PB - American Public Health Association
SN - 00900036
AB - Background: Urinary tract stones (stones) arc believed to be unusually common in the southeastern United States but neither the incidence of nor the risk factors for stones are known. Methods: In three well-defined occupational populations in eastern Tennessee, we assessed the prevalence, incidence, and cumulative incidence of stones and measured biochemical risk factors for lithogenesis. Results: The age-adjusted prevalence of stones was 18.5 percent in Tennessee compared to 7.7 percent among White males in US NHANES (prevalence ratio 2.4, 95% Cl 1.7, 3.3). The cumulative incidence (risk) was 27.8 percent by age 65, higher than in any other reported population. Risk factors were age, a family history, and urinary saturation with calcium-oxalate (COAX). Persons with a positive family history and the highest measured CAOX index had a predicted lifetime risk of 88.8 percent. Biochemical factors affecting lithogenesis were hypercalcuria, hyperoxaluria, and low urine volume. Conclusion: Future research should characterize the geographic boundaries of a southeastern "stone-belt" and explore genetic and dietary hypotheses that might explain it. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINARY calculi
KW - URINARY organs -- Diseases
KW - PATHOLOGY
KW - KIDNEY stones
KW - URINARY tract infections
KW - GENEALOGY
KW - PUBLIC health
KW - UROLOGY
KW - TENNESSEE
N1 - Accession Number: 9107081085; Thun, Michael J. 1 Schober, Susan 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: May91, Vol. 81 Issue 5, p587; Subject Term: URINARY calculi; Subject Term: URINARY organs -- Diseases; Subject Term: PATHOLOGY; Subject Term: KIDNEY stones; Subject Term: URINARY tract infections; Subject Term: GENEALOGY; Subject Term: PUBLIC health; Subject Term: UROLOGY; Subject Term: TENNESSEE; NAICS/Industry Codes: 812990 All Other Personal Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sullivan, Louis W.
AU - Sullivan, L W
T1 - From the Secretary of Health and Human Services.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/05/22/
VL - 265
IS - 20
M3 - journal article
SP - 2652
EP - 2652
SN - 00987484
AB - Presents the text of a speech given by Louis L. Sullivan, secretary of Health and Human Services of the U.S., which deals with child survival and AIDS in Africa.
KW - AIDS (Disease)
KW - CHILDREN
KW - AFRICA
KW - UNITED States. Dept. of Health & Human Services
KW - SULLIVAN, Louis
N1 - Accession Number: 10418025; Sullivan, Louis W. Sullivan, L W 1; Affiliation: 1: Secretary for Health and Human Services, Washington, DC; Source Info: 5/22/91-5/29/91, Vol. 265 Issue 20, p2652; Subject Term: AIDS (Disease); Subject Term: CHILDREN; Subject Term: AFRICA; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: SULLIVAN, Louis; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stout, Nancy
AU - Bell, Catherine
T1 - Effectiveness of Source Documents for Identifying Fatal Occupational Injuries: A Synthesis of Studies.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 725
EP - 728
PB - American Public Health Association
SN - 00900036
AB - Background: The complete and accurate identification of fatal occupational injuries among the US workforce is an important first step in developing work injury prevention efforts. Numerous sources of information, Numerous sources of information, such as death certificates, Workers' Compensation files, Occupational Safety and Health Administration (OSHA), files, medical examiner records, state health and labor department reports, and various combinations of these, have been used to identify cases of work-related fatal injuries. Recent studies have questioned the effectiveness of these sources for identifying such cases. Methods: At least 10 studies have used multiple sources to define the universe of fatal work injuries within a state and to determine the capture rates, or proportion of the universe identified, by each source. Results of these studies, which are not all available in published literature, are summarized here in a format that allows researchers to readily compare the ascertainment capabilities of the sources. Results: The overall average capture rates of sources were as follows: death certificates, 81%; medical examiner records, 61%; Workers' Compensation reports, 57%; and OSHA reports 32%. Variations by state and value added through the use of multiple sources are presented and discussed. Conclusions: This meta-analysis of 10 state-based studies summarizes the effectiveness of various source documents for capturing cases of fatal occupational injuries to help researchers make informed decisions when designing occupational injury surveillance systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - ACCIDENTS
KW - DISASTERS
KW - WORKERS' compensation
KW - EMPLOYERS' liability
KW - INSURANCE
KW - ACCIDENT insurance
KW - HEALTH insurance
KW - SOCIAL security
N1 - Accession Number: 9107224895; Stout, Nancy 1 Bell, Catherine 1; Affiliation: 1: National Institute for Occupational Safety and Health; Source Info: Jun91, Vol. 81 Issue 6, p725; Subject Term: WORK-related injuries; Subject Term: ACCIDENTS; Subject Term: DISASTERS; Subject Term: WORKERS' compensation; Subject Term: EMPLOYERS' liability; Subject Term: INSURANCE; Subject Term: ACCIDENT insurance; Subject Term: HEALTH insurance; Subject Term: SOCIAL security; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524113 Direct Life Insurance Carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Catherine A.
T1 - Female Homicides in United States Workplaces, 1980-1985.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 729
EP - 732
PB - American Public Health Association
SN - 00900036
AB - Background: Women, while noted for low occupational injury mortality rates, are more likely to die as victims of assault than from any other manner of injury at work. Methods: From the National Traumatic Occupational Fatality surveillance data, 950 women were identified who were fatally assaulted at work. Homicide rates were calculated for the demographic and employment characteristics of these women. Risk ratios among types of lethal injuries were examined. Results: During 1980-1985, the crude six-year workplace homicide rate was 4.0 deaths per million working women: one twentieth the homicide rate of the US female population. Decedents ranged from 16 years (the lowest age included in the data base) to 93 years of age. Working women older than 65 years had the highest age-specific homicide rate, 11.3 per million. Women younger than 20 had the lowest, 2.5 per million per year. Homicide rates for women of races other than White were nearly twice as high as those of Whites. The leading causes of death were gunshot wounds (64 percent), stabbings (19 percent), asphyxiations (7 percent), and blunt force trauma (6 percent). Nearly 43 percent of the deceased women had been employed in retail trade: 8.7 per million employed women annually. Conclusions: During 1980-1985, only 6 percent of the nation's victims of work-related injury deaths were female: 41 percent of those women were murdered. Homicide is currently the leading manner of traumatic workplace death among women in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMICIDE
KW - CRIMINAL law
KW - OFFENSES against the person
KW - VIOLENT deaths
KW - WOMEN -- United States
KW - MORTALITY
KW - DEATH
KW - DEMOGRAPHY
KW - GUNSHOT wounds
N1 - Accession Number: 9107224896; Bell, Catherine A. 1; Affiliation: 1: National institute for Occupational Safety and Health, Morgantown; Source Info: Jun91, Vol. 81 Issue 6, p729; Subject Term: HOMICIDE; Subject Term: CRIMINAL law; Subject Term: OFFENSES against the person; Subject Term: VIOLENT deaths; Subject Term: WOMEN -- United States; Subject Term: MORTALITY; Subject Term: DEATH; Subject Term: DEMOGRAPHY; Subject Term: GUNSHOT wounds; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Etherton, John R.
AU - Myers, John R.
AU - Jensen, Roger C.
AU - Russell, Julie C.
AU - Braddee, Richard W.
T1 - Agricultural Machine-Related Deaths.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/06//
VL - 81
IS - 6
M3 - Article
SP - 766
EP - 768
PB - American Public Health Association
SN - 00900036
AB - Analysis of 1980-1985 death certificate data for the United States indicated that an average of 369 occupational deaths per yeas involved agricultural machinery as the external cause of death. Out of all agricultural machine-related deaths, tractors accounted for 69 percent. Over half of these tractor-related deaths were, rollovers. There is a need for public health programs to effect greeter use of rollover protective structures (ROPS) on farm tractors. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURAL equipment
KW - MACHINERY
KW - FARM mechanization
KW - DEATH
KW - PUBLIC health
KW - ROLLOVER protective structures (Machinery)
KW - MACHINERY -- Safety appliances
KW - AGRICULTURAL equipment -- Rollover protective structures
N1 - Accession Number: 9107224908; Etherton, John R. 1 Myers, John R. 1 Jensen, Roger C. 1 Russell, Julie C. 1 Braddee, Richard W. 1; Affiliation: 1: Division of Safety Research, National institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Jun91, Vol. 81 Issue 6, p766; Subject Term: AGRICULTURAL equipment; Subject Term: MACHINERY; Subject Term: FARM mechanization; Subject Term: DEATH; Subject Term: PUBLIC health; Subject Term: ROLLOVER protective structures (Machinery); Subject Term: MACHINERY -- Safety appliances; Subject Term: AGRICULTURAL equipment -- Rollover protective structures; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417990 All other machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333999 All Other Miscellaneous General Purpose Machinery Manufacturing; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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ER -
TY - JOUR
AU - kelley, Ingrid
AU - Pfiester, Lois A.
T1 - ULTRASTRUCTURE OF GLOEODINIUM MONTANUM (DINOPHYCEAE).
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1991/06//
VL - 27
IS - 3
M3 - Article
SP - 414
EP - 423
SN - 00223646
AB - The freshwater dinoflagellate Gloeodinium montanum Klebs (1912) was examined with transmission and scanning electron microscopy. Micrographs of ultrathin sections revealed a series of membrane layers rather than the usual dinoflagellate theca in vegetative cysts and in zygotes. Swarmers had distinct pellicles but appeared to be devoid of thecal plates and vesicles. The organization of cysts and swarmers appeared remarkably similar. All cell types had typical dinoflagellate nuclei with condensed chromosomes. Chloroplasts had girdle lamellae. One pyrenoid per cell was also present in chloroplasts of vegetative cysts. Starch grains and oil globules were distributed throughout the cytoplasm. Large accumulation bodies and polyvesicular vacuoles were found in aging cysts. Trichocysts and flagellar hairs were absent. Two types of intra-cellular prokaryotic organisms were discovered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DINOFLAGELLATES
KW - MICROSCOPY
KW - ZYGOTES
KW - CHROMOSOMES
KW - Dinocapsales
KW - Gloeodinium montanum
KW - Pyrrophyta
KW - ultrastructure.
N1 - Accession Number: 10767327; kelley, Ingrid 1,2 Pfiester, Lois A. 1; Affiliation: 1: Department of botany and Microbiology, University of Oklahoma. 2: National Center for Toxicological Research, Jefferson, Arkansas.; Source Info: Jun91, Vol. 27 Issue 3, p414; Subject Term: DINOFLAGELLATES; Subject Term: MICROSCOPY; Subject Term: ZYGOTES; Subject Term: CHROMOSOMES; Author-Supplied Keyword: Dinocapsales; Author-Supplied Keyword: Gloeodinium montanum; Author-Supplied Keyword: Pyrrophyta; Author-Supplied Keyword: ultrastructure.; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/1529-8817.ep10767327
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MILLER, HENRY I.
AU - BURRIS, ROBERT H.
AU - VIDAVER, ANNE K.
T1 - Regulation of Biotechnology.
JO - Science
JF - Science
Y1 - 1991/06/21/
VL - 252
IS - 5013
M3 - Article
SP - 1599
EP - 1600
SN - 00368075
N1 - Accession Number: 87437351; MILLER, HENRY I. 1 BURRIS, ROBERT H. 2 VIDAVER, ANNE K. 3; Affiliation: 1: Office of Biotechnology, Food and Drug Administration, Rockville, MD 20857 2: Department of Biochemistry, University of Wisconsin, Madison, W 53706 3: Department of Plant Pathology, University of Nebraska, Lincoln, NE 68583; Source Info: 6/21/1991, Vol. 252 Issue 5013, p1599; Number of Pages: 2p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Grossman, David C.
AU - Milligan, Carol
AU - Deyo, Richard A.
T1 - Risk Factors for Suicide Attempts among Navajo Adolescents.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/07//
VL - 81
IS - 7
M3 - Article
SP - 870
EP - 874
PB - American Public Health Association
SN - 00900036
AB - Background: Rates of adolescent suicide in the United States are highest among Native Americans but little is known about risk factors for suicide attempts in this population. Methods: To identify risk factor self-reported suicide attempts by Navajo adolescents, we analyzed the 1988 Indian Health Service Adolescent Health Survey that was administered to 7,254 students in grades 6 through 12 on the Navajo reservation. The responses of students reporting a past suicide attempt were compared to others. Results: Nearly 15 percent (N = 971) reported a previous suicide attempt; of those admitted to more than one attempt. Controlling for age, a logistic regression model revealed the following associations with suicide attempts: a history of mental health problems (OR = 3.2); alienation from family (OR = 3.2) having a attempted suicide (OR = 2.8); weekly consumption of hard liquor (OR = 2.7); a family history of a suicide or attempt (OR = 2.3); poor self-perception of health (OR = 2.2); a history of physical abuse (OR = 1.9) female gender (OR = 1.7); and sexual abuse (OR = 1.5). Conclusions: adolescent suicide attempts in this population should target individuals with those risk factors of the highest risk and prevalence of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUICIDAL behavior
KW - SUICIDE -- Risk factors
KW - TEENAGERS -- Suicidal behavior
KW - SELF-destructive behavior
KW - MENTAL health
KW - PHYSICAL abuse
KW - SEX crimes
KW - SELF-perception in adolescence
KW - UNITED States
N1 - Accession Number: 9108050288; Grossman, David C. 1 Milligan, Carol 2 Deyo, Richard A. 3,4; Affiliation: 1: Department of Pediatrics, University of Washington, and Harborview Injury Prevention and Research Center, 325 Ninth Avenue, ZX-10, Seattle, WA 98104 2: Maternal and Child Health Branch, Navajo Area Indian Health Service, Window Rock, AZ 3: Department of Medicine, University of Washington and Seattle Veterans Affairs Medical Center 4: Health Services, University of Washington and Seattle Veterans Affairs Medical Center; Source Info: Jul1991, Vol. 81 Issue 7, p870; Subject Term: SUICIDAL behavior; Subject Term: SUICIDE -- Risk factors; Subject Term: TEENAGERS -- Suicidal behavior; Subject Term: SELF-destructive behavior; Subject Term: MENTAL health; Subject Term: PHYSICAL abuse; Subject Term: SEX crimes; Subject Term: SELF-perception in adolescence; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Garza, Alvaro
AU - Mutchinick, Osvtddo
AU - Cordero, Jose F.
AU - Burse, Virfyn W.
T1 - International Collaboration in a Cluster Investigation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/08//
VL - 81
IS - 8
M3 - Letter
SP - 1077
EP - 1078
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented about the investigation of an alleged cluster of children with facial malformations in 1987 in Matamoros, Mexico by the Mexican National Institute of Nutrition, the Pan American Health Organization and the U.S. Centers for Disease Control.
KW - LETTERS to the editor
KW - FACIAL abnormalities
N1 - Accession Number: 20671838; Garza, Alvaro 1 Mutchinick, Osvtddo 2 Cordero, Jose F. 3 Burse, Virfyn W. 3; Affiliation: 1: Pan American Health Organization of the World Health Organization in Metepec, Mexico 2: Instituto Nacional de la Nutricion Salvador Zubiran in Tlalpan, Mexico 3: Centers for Disease Control, US Department of Health and Human Services, Atlanta, Ga; Source Info: Aug1991, Vol. 81 Issue 8, p1077; Subject Term: LETTERS to the editor; Subject Term: FACIAL abnormalities; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Puri, R. K.
AU - Leland, P.
T1 - In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1991/08//
VL - 85
IS - 2
M3 - Article
SP - 317
EP - 325
PB - Wiley-Blackwell
SN - 00099104
AB - Interferon-alpha (IFN-α) has been shown to synergize with IL-2 in the regression of a variety of established murine tumours and studies are underway to explore this combination in patients with advanced cancers as well. To understand the mechanism of synergy we have studied lymphokine- activated killer (LAK) cell activity in various compartments of mice in response to IFN-α and IL-2 administration. The effects of IFN-γ TNF-α and IL-4 were also examined. C57BL/6 mice were injected intraperitoneally with HBSS, IL-2 alone, IFN-α alone or both, two times a day for 7 days. On days 4 and 8, LAK activity was tested in a 4-h chromium release in cells obtained from lungs, spleen, and liver using fresh MCA-102 tumour cells as targets. The cells from control mice failed to lyse the MCA-102 target. IL-2 caused the generation of LAK activity and an increase in total cell yield in all the organs after 3 days of injection. IFN-α failed to generate LAK activity but when administered along with IL-2, caused synergistic enhancement of LAK lysis of MCA-102 target cells. Cell yield in this group was lower as compared with the IL-2-treated group. LAK activity tested after 7 days of IL-2 therapy was significantly decreased compared with that observed after 3 days. However, activity remained at as high a level after 7 days of therapy as after 3 days of therapy in animals treated with IFN-α and IL-2. FACS analysis revealed that asialo GM-1+ (ASGM-1) and NK1.1+ cells were increased in number in IL-2 and IL-2 plus IFN-α-treated spleen; however, the number of these cells was similar in both groups. In the liver, ASGM-1+ cells were higher in the IL-2 plus IFN-α group than in the group treated with IL-2 alone. By in vitro depletion utilizing antibody and Rbc' experiments, it was clear that both ASGM-1+ and NK 1.1+ cells from the spleen mediated most of the cytotoxicity of MCA-102 targets. Pre-treatment irradiation (5 Gy) of mice completely abrogated the capability of IL-2 or IL-2 plus IFN-α to generate LAK activity. IFN-α also had a stimulatory effect on IL-2 induction of LAK activity. Tumour necrosis factor-alpha (TNF-α) and IL-4 failed to generate LAK activity and, in combination with IL-2, no additional stimulatory effect was observed. These studies indicate that induction of LAK activity may be at least partly responsible in the mediation of synergistic anti-tumour effects of IFN-α and IL-2 or IFN-γ and IL-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - TUMORS
KW - CANCER patients
KW - LYMPHOKINES
KW - KILLER cells
KW - TUMOR necrosis factor
KW - cytotoxic lymphocytes
KW - in vivo therapy
KW - LAK cells
N1 - Accession Number: 16173485; Puri, R. K. 1 Leland, P. 1; Affiliation: 1: Laboratory of Cellular Immunology, Division of Cytokine Biology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA.; Source Info: Aug1991, Vol. 85 Issue 2, p317; Subject Term: INTERFERONS; Subject Term: TUMORS; Subject Term: CANCER patients; Subject Term: LYMPHOKINES; Subject Term: KILLER cells; Subject Term: TUMOR necrosis factor; Author-Supplied Keyword: cytotoxic lymphocytes; Author-Supplied Keyword: in vivo therapy; Author-Supplied Keyword: LAK cells; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patterson, Gregory M.L.
AU - Baldwin, Cynthia L.
AU - Boils, Christine M.
AU - Caplan, Faith R.
AU - Karuso, Helen
AU - Larsen, Linda K.
AU - Levine, Ira A.
AU - Moore, Richard E.
AU - Nelson, Carrie S.
AU - Tschappat, Kathryn D.
AU - Taung, Grace D.
AU - Furusawa, Eiichi
AU - Furusawa, Shinobu
AU - Norton, Ted R.
AU - Raybourne, Richard B.
T1 - ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE-GREEN ALGAE (CYANOPHYTA).
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1991/08//
VL - 27
IS - 4
M3 - Article
SP - 530
EP - 536
SN - 00223646
AB - A large-scale screening program was initiated to evaluate laboratory-cultured blue-algae (cyanobacteria) as a source of novel antineoplastic agents. Approximately 1000 cyanophyte strains from divers habitats were cultured to provide extracts for testing. The screening program identified the families Scytonemataceae and Stigonemataceae as prolific producers of novel cytotoxic compounds. Rates of rediscovery of known compound were relatively low. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYANOBACTERIA
KW - ANTINEOPLASTIC agents
KW - MICROALGAE
KW - NATURAL products
KW - DRUGS
KW - CELL culture
KW - anticancer
KW - cyanobacteria
KW - microalgae
KW - natural products
KW - pharmaceutical
N1 - Accession Number: 10767477; Patterson, Gregory M.L. 1 Baldwin, Cynthia L. 1 Boils, Christine M. 1 Caplan, Faith R. 1 Karuso, Helen 1 Larsen, Linda K. 1 Levine, Ira A. 1 Moore, Richard E. 1 Nelson, Carrie S. 1 Tschappat, Kathryn D. 1 Taung, Grace D. 1 Furusawa, Eiichi 2 Furusawa, Shinobu 2 Norton, Ted R. 2 Raybourne, Richard B. 3; Affiliation: 1: Department of Chemistry, University of Hawaii, Honolulu, Hawaii 96822. 2: Department of Pharmacology, University of hawaii, Honolulu, hawaii 96822. 3: Division of Microbiology, U.S. Food and Drug Administration, 200 C. Street S.W. Washington, D.C. 20204.; Source Info: Aug91, Vol. 27 Issue 4, p530; Subject Term: CYANOBACTERIA; Subject Term: ANTINEOPLASTIC agents; Subject Term: MICROALGAE; Subject Term: NATURAL products; Subject Term: DRUGS; Subject Term: CELL culture; Author-Supplied Keyword: anticancer; Author-Supplied Keyword: cyanobacteria; Author-Supplied Keyword: microalgae; Author-Supplied Keyword: natural products; Author-Supplied Keyword: pharmaceutical; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1529-8817.ep10767477
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Athey, Jean L.
T1 - HIV Infection and Homeless Adolescents.
JO - Child Welfare
JF - Child Welfare
Y1 - 1991/09//Sep/Oct91
VL - 70
IS - 5
M3 - Article
SP - 517
EP - 528
PB - Child Welfare League of America
SN - 00094021
AB - This article analyzes the risks for homeless adolescents of acquiring HIV infection and the service initiatives for meeting the challenges these adolescents. Data from several community surveys and youth shelters have suggested that around one and 1.3 million adolescents are in emergency shelters or on the streets in any given year. Workers who work closely with homeless youths reported high levels of sexual activity between them, some of them have it as voluntarily and some not. The sexual activity among themselves could lead to HIV infection. The sexual activity of these young people can be classified in three ways such as rape, survival sex or a love relationship.
KW - HOMELESS persons
KW - HIV infections
KW - SEXUAL intercourse
KW - HOMELESSNESS
KW - SOCIAL surveys
KW - DATA analysis
KW - INTERPERSONAL relations
KW - LENTIVIRUS diseases
N1 - Accession Number: 9110071887; Athey, Jean L. 1; Affiliation: 1: Chief, Public Health Social Work, Child and Adolescent Health Branch, Maternal and Child Health Bureau. U.S. Department of Health and Human Services, Rockville, MD; Source Info: Sep/Oct91, Vol. 70 Issue 5, p517; Subject Term: HOMELESS persons; Subject Term: HIV infections; Subject Term: SEXUAL intercourse; Subject Term: HOMELESSNESS; Subject Term: SOCIAL surveys; Subject Term: DATA analysis; Subject Term: INTERPERSONAL relations; Subject Term: LENTIVIRUS diseases; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 4826
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martone, William J.
T1 - Year 2000 Objectives for Preventing Nosocomial Infections: How Do We Get There'.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 39S
EP - 43S
SN - 00029343
AB - Reports on the U.S. Public Health Service Year 1990 and Year 2000 Objectives that contain plans for preventing and controlling nosocomial infections. Protection of the health care worker and patient; Role of the U.S. Occupational Health and Safety Administration in attaining the health care worker objectives.
KW - NOSOCOMIAL infections -- Prevention
KW - MEDICAL personnel
KW - UNITED States. Public Health Service
KW - UNITED States. Occupational Safety & Health Administration
N1 - Accession Number: 10939481; Martone, William J. 1; Affiliation: 1: Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Georgia; Source Info: 9/16/91, Vol. 91 Issue 3B, p39S; Subject Term: NOSOCOMIAL infections -- Prevention; Subject Term: MEDICAL personnel; Company/Entity: UNITED States. Public Health Service Company/Entity: UNITED States. Occupational Safety & Health Administration; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Banerjee, Shailen N.
AU - Emori, T. Grace
AU - Culver, David H.
AU - Gaynes, Robert P.
AU - Jarvis, William R.
AU - Horan, Teresa
AU - Edwards, Jonathan R.
AU - Tolson, James
AU - Henderson, Tonya
AU - Martone, William J.
T1 - Secular Trends in Nosocomial Primary Bloodstream Infections in the United States, 1980-1989.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 86S
EP - 89S
SN - 00029343
AB - Estimates the change in nosocomial primary bloodstream infections (BSI) rates during 1980-1989 in acute care hospitals in the U.S. from data reported by National Nosocomial Infections Surveillance Systems Hospitals. Calculation of BSI rates by hospital stratum and pathogen groups; Stability of BSI rate due to gram-negative bacilli.
KW - NOSOCOMIAL infections
KW - BLOODBORNE infections
KW - GRAM-negative bacteria
KW - UNITED States
N1 - Accession Number: 10939488; Banerjee, Shailen N. 1 Emori, T. Grace 1 Culver, David H. 1 Gaynes, Robert P. 1 Jarvis, William R. 1 Horan, Teresa 1 Edwards, Jonathan R. 1 Tolson, James 1 Henderson, Tonya 1 Martone, William J. 1; Affiliation: 1: Hospital Infections Program, Center for Infectious Diseases, Centers for Disease Control, United States Public Health Service, Department of Health and Human Services, Georgia; Source Info: 9/16/91, Vol. 91 Issue 3B, p86S; Subject Term: NOSOCOMIAL infections; Subject Term: BLOODBORNE infections; Subject Term: GRAM-negative bacteria; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jarvis, William R.
T1 - Nosocomial Outbreaks: The Centers for Disease Control's Hospital Infections Program Experience, 1980-1990.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 101S
EP - 106S
SN - 00029343
AB - Provides an overview of outbreaks investigated by the Hospital Infections Program of the U.S. Centers for Disease Control and Prevention (CDC) from 1980-1990. Examples of the epidemiologic and laboratory approach to outbreak investigation; Increase in the understanding of the epidemiology of nosocomial infections due to the close collaboration between the CDC, state and local health authorities, foreign governments and infection control practitioners in hospitals.
KW - NOSOCOMIAL infections
KW - EPIDEMICS
KW - EPIDEMIOLOGY
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 10939491; Jarvis, William R. 1; Affiliation: 1: Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control, United States Public Health Service, Georgia; Source Info: 9/16/91, Vol. 91 Issue 3B, p101S; Subject Term: NOSOCOMIAL infections; Subject Term: EPIDEMICS; Subject Term: EPIDEMIOLOGY; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Richet, H.M.
AU - Chidiac, C.
AU - Prat, A.
AU - Pol, A.
AU - David, M.
AU - Maccario, M.
AU - Cormier, P.
AU - Bernard, E.
AU - Jarvis, W.R.
T1 - Analysis of Risk Factors for Surgical Wound Infections Following Vascular Surgery.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 170S
EP - 172S
SN - 00029343
AB - Presents a prospective multicenter study to identify risk factors for surgical wound infections (SWI) and compares two regimens of antimicrobial prophylaxis. Independent risk factors found for SWI using multivariate analysis with logistic regression analyses; Serious consequences of SWI.
KW - SURGICAL wound infections
KW - ANTI-infective agents
KW - MULTIVARIATE analysis
KW - LOGISTIC regression analysis
KW - RISK factors
N1 - Accession Number: 10939503; Richet, H.M. 1 Chidiac, C. 2 Prat, A. 2 Pol, A. 2 David, M. 2 Maccario, M. 2 Cormier, P. 2 Bernard, E. 2 Jarvis, W.R. 1; Affiliation: 1: Hospital Infections Program, Center for Infectious Diseases, Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services 2: Groupe d'Etude et Recherche en Antibioprophylaxie, France; Source Info: 9/16/91, Vol. 91 Issue 3B, p170S; Subject Term: SURGICAL wound infections; Subject Term: ANTI-infective agents; Subject Term: MULTIVARIATE analysis; Subject Term: LOGISTIC regression analysis; Subject Term: RISK factors; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pegues, David A.
AU - Shireley, Larry A.
AU - Riddle, Conradine F.
AU - Anderson, Roger L.
AU - Vess, Robert W.
AU - Hill, Bertha C.
AU - Jarvis, William R.
T1 - Serratia marcescens Surgical Wound Infection Following Breast Reconstruction.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 173S
EP - 178S
SN - 00029343
AB - Reports on the cases of four patients from a plastic surgeon's practice who developed Serratia marcescens surgical wound infection (SWI) following breast reconstruction procedures with implantation of six expandable mammary implants, from April to November 1989. Association of the infections with saline expansion of the implants; Hypothesis that the use of saline bags and nonsterile expansion technique contaminated saline solutions and resulted in implant and/or surgical site infections.
KW - SERRATIA marcescens
KW - SURGICAL wound infections
KW - BREAST implants
KW - MAMMAPLASTY
N1 - Accession Number: 10939504; Pegues, David A. 1 Shireley, Larry A. 2 Riddle, Conradine F. 1 Anderson, Roger L. 1 Vess, Robert W. 1 Hill, Bertha C. 1 Jarvis, William R. 1; Affiliation: 1: Hospital Infections Program, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Georgia 2: North Dakota State Department of Health and Consolidated Laboratories; Source Info: 9/16/91, Vol. 91 Issue 3B, p173S; Subject Term: SERRATIA marcescens; Subject Term: SURGICAL wound infections; Subject Term: BREAST implants; Subject Term: MAMMAPLASTY; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jarvis, William R.
AU - Edwards, Jonathan R.
AU - Culver, David H.
AU - Hughes, James M.
AU - Horan, Teresa
AU - Emori, T. Grace
AU - Banerjee, Shailen
AU - Tolson, James
AU - Henderson, Tonya
AU - Gaynes, Robert P.
AU - Martone, William J.
T1 - Nosocomial Infection Rates in Adult and Pediatric Intensive Care Units in the United States.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 185S
EP - 191S
SN - 00029343
AB - Reports on the use of the National Nosocomial Infections Surveillance (NNIS) System Intensive Care Unit (ICU) Database to determine which factors influence ICU infection rates. Comparison of various rates as to their usefulness in assessing secular trends in nosocomial infection, in comparing rates among hospitals and in providing a basis for improved prevention of nosocomial infections in ICU; Examination of device-associated nosocomial infection rates.
KW - NOSOCOMIAL infections -- Prevention
KW - INTENSIVE care units
KW - HOSPITALS
KW - INFECTION -- Prevention
N1 - Accession Number: 10939506; Jarvis, William R. 1 Edwards, Jonathan R. 1 Culver, David H. 1 Hughes, James M. 1 Horan, Teresa 1 Emori, T. Grace 1 Banerjee, Shailen 1 Tolson, James 1 Henderson, Tonya 1 Gaynes, Robert P. 1 Martone, William J. 1; Affiliation: 1: Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, Georgia; Source Info: 9/16/91, Vol. 91 Issue 3B, p185S; Subject Term: NOSOCOMIAL infections -- Prevention; Subject Term: INTENSIVE care units; Subject Term: HOSPITALS; Subject Term: INFECTION -- Prevention; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 7p; Illustrations: 15 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emori, T. Grace
AU - Banerjee, Shailen N.
AU - Culver, David H.
AU - Gaynes, Robert P.
AU - Horan, Teresa C.
AU - Edwards, Jonathan R.
AU - Jarvis, William R.
AU - Tolson, James S.
AU - Henderson, Tonya S.
AU - Martone, William J.
AU - Hughes, James M.
T1 - Nosocomial Infections in Elderly Patients in the United States, 1986-1990.
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 1991/09/16/
VL - 91
IS - 3B
M3 - Article
SP - 289S
EP - 293S
SN - 00029343
AB - Provides background information on the nature of nosocomial infections (NI) in the elderly in order to help to develop infection control measures that will lower the risk of NI. Use of data from hospitals participating in the National Nosocomial Infections Surveillance system; Need for infection prevention efforts to target infections that occur frequently, are amenable to intervention and have an adverse outcome.
KW - NOSOCOMIAL infections -- Prevention
KW - INFECTION -- Prevention
KW - OLDER people
KW - UNITED States
N1 - Accession Number: 10939523; Emori, T. Grace 1 Banerjee, Shailen N. 1 Culver, David H. 1 Gaynes, Robert P. 1 Horan, Teresa C. 1 Edwards, Jonathan R. 1 Jarvis, William R. 1 Tolson, James S. 1 Henderson, Tonya S. 1 Martone, William J. 1 Hughes, James M. 1; Affiliation: 1: Hospital Infections Program, and the Office of the Director, National Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, Department of Health and Human Services, Georgia; Source Info: 9/16/91, Vol. 91 Issue 3B, p289S; Subject Term: NOSOCOMIAL infections -- Prevention; Subject Term: INFECTION -- Prevention; Subject Term: OLDER people; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desenclos, Jean-Claude A.
AU - Klontz, Karl C.
AU - Wilder, Michael H.
AU - Nainan, Omana V.
AU - Margolis, Harold S.
AU - Gunn, Robert A.
T1 - A Multistate Outbreak of Hepatitis A Caused by the Consumption of Raw Oysters.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/10//
VL - 81
IS - 10
M3 - Article
SP - 1268
EP - 1272
PB - American Public Health Association
SN - 00900036
AB - Background. In August 1988 we investigated a multistate outbreak of hepatitis A caused by Panama City, Florida, raw oysters. Methods. Cases of hepatitis A (HA) with onset in July-August 1988 were identified among persons who ate seafoods harvested in the coastal waters of Panama City, Florida. We conducted a case-control study, using eating companions of case-patients, and calculated attack rate (AR) per 1000 dozen raw oysters served. Enzyme immunoassay (EIA) and a polymerase chain reaction (PCR) technique were performed on samples of raw shellfish obtained from Panama City coastal waters. Results. Sixty-one case-patients were identified in five states: Alabama (23), Georgia (18), Florida (18), Tennessee (1), and Hawaii (1). We found an increased risk of HA for raw oyster eaters (odds ratio = 24.0; 95% confidence interval = 5.4-215.0; P < .001). The AR of HA in seafood establishments was 1.9/1000 dozen raw oysters served. The EIA and PCR revealed HA virus antigen and nucleic acid in oysters from both unapproved and approved oyster beds, in confiscated illegally harvested oysters, and in scallops from an approved area. Conclusions. The monitoring of coastal waters and the enforcement of shellfish harvesting regulations were not adequate to protect raw oyster consumers. More emphasis should be placed on increasing public awareness of health hazards associated with eating raw shellfish. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A
KW - EPIDEMICS
KW - OYSTERS
KW - RAW foods
KW - ENZYME-linked immunosorbent assay
KW - POLYMERASE chain reaction
KW - PANAMA City (Fla.)
KW - FLORIDA
N1 - Accession Number: 9112090809; Desenclos, Jean-Claude A. 1 Klontz, Karl C. 2 Wilder, Michael H. 2 Nainan, Omana V. 3 Margolis, Harold S. 3 Gunn, Robert A. 1; Affiliation: 1: Division of Field Epidemiology, Centers for Disease Control, Public Health Service, Atlanta 2: Disease Control, Florida Department of Health and Rehabilitative Services, Tallahassee, Fla. 3: Hepatitis Branch, Centers for Disease Control, Public Health Service, Atlanta; Source Info: Oct91, Vol. 81 Issue 10, p1268; Subject Term: HEPATITIS A; Subject Term: EPIDEMICS; Subject Term: OYSTERS; Subject Term: RAW foods; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: POLYMERASE chain reaction; Subject Term: PANAMA City (Fla.); Subject Term: FLORIDA; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Russell, Julie
AU - Conroy, Carol
T1 - Representativeness of Deaths Identified Through the Injury-at-Work Item on the Death Certificate: Implications for Surveillence.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1991/12//
VL - 81
IS - 12
M3 - Article
SP - 1613
EP - 1613
PB - American Public Health Association
SN - 00900036
AB - Background. This research investigated the accuracy of the injury-at-work item on the death certificate for surveillance of occupational injury deaths in Oklahoma during 1985 and 1986. Methods. Representativeness of occupational injury deaths identified by death certificates was assessed by comparing these deaths with all occupational injury deaths identified through death certificates, workers' compensation reports, medical examiner reports, and OSHA records for categories of occupation, industry, and external causes of death. Results. Certain external causes of death (e.g., motor vehicle traffic deaths) and certain occupations (e.g., fanning) and industries (agriculture and services) are more often underidentified through death certificates. Conclusions. The findings of this study support Baker's observation that no single data source contains all deaths or all the data elements necessary to describe occupational injury deaths. Data sources may be combined to improve representativeness through more complete case ascertainment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - DEATH -- Causes
KW - CLASSIFICATION
KW - OCCUPATIONAL mortality
KW - DEATH -- Proof & certification
KW - DEATH certificates
KW - WORKERS' compensation
KW - OCCUPATIONS
KW - ACCIDENTS
KW - UNITED States
N1 - Accession Number: 9202101749; Russell, Julie 1,2 Conroy, Carol 1,3; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WVa 2: Division of Injury Control, Centers for Disease Control, Atlanta 3: California Occupational Health Program, Berkeley; Source Info: Dec1991, Vol. 81 Issue 12, p1613; Subject Term: WORK-related injuries; Subject Term: DEATH -- Causes; Subject Term: CLASSIFICATION; Subject Term: OCCUPATIONAL mortality; Subject Term: DEATH -- Proof & certification; Subject Term: DEATH certificates; Subject Term: WORKERS' compensation; Subject Term: OCCUPATIONS; Subject Term: ACCIDENTS; Subject Term: UNITED States; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 6p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mason, James O.
T1 - Protecting Physicians From Vaccine Liability.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1991/12/04/
VL - 266
IS - 21
M3 - Article
SP - 2951
EP - 2951
SN - 00987484
AB - Discusses the U.S. Vaccine Injury Compensation Program which was created in the National Childhood Vaccine Injury Act of 1986. Standards for tort actions alleging injury from diphtheria, tetanus, pertussis and polio vaccines; Filing of vaccine injury claims; Eligibility of compensation through the program.
KW - MEDICAL care
KW - VACCINES
KW - THERAPEUTICS
KW - UNITED States
N1 - Accession Number: 10980282; Mason, James O. 1; Affiliation: 1: Public Health Service; Source Info: 12/4/91, Vol. 266 Issue 21, p2951; Subject Term: MEDICAL care; Subject Term: VACCINES; Subject Term: THERAPEUTICS; Subject Term: UNITED States; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doll, Lynda S.
AU - Petersen, Lyle R.
AU - White, Carol R.
AU - Johnson, Eric S.
AU - Ward, John W.
T1 - Homosexually and Nonhomosexually Identified Men Who Have Sex With Men: A Behavioral Comparison.
JO - Journal of Sex Research
JF - Journal of Sex Research
Y1 - 1992/02//
VL - 29
IS - 1
M3 - Article
SP - 1
EP - 14
PB - Routledge
SN - 00224499
AB - From January 1988 to September 1989, 209 HIV-1 seropositive male blood donors who reported sex with men were interviewed at 20 U.S. blood centers. Most (59%) were Black or Hispanic and self-identified as bisexual (30%) or heterosexual (25%). During the year before their last donation, 73% of homosexually, 62% of bisexually, and 29% of heterosexually identified men had engaged in unprotected anal sex with men. Overall, few had ties to gay communities; however; 24% of bisexually and 58% of heterosexually identified men had female primary partners. There were no racial/ethnic differences in gender of partners in the last year, although Blacks were more likely to identify themselves as bisexual (44%) and Hispanics as heterosexual (34%). These data suggest the need to target prevention efforts at men having unprotected sex with male or female partners, regardless of sexual identity, and to examine social network and cultural influences affecting sexual behavior and sexual identity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Sex Research is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEN -- Sexual behavior
KW - GAY people -- Sexual behavior
KW - HIV-positive persons
KW - HETEROSEXUALS
KW - GAY community
KW - HUMAN sexuality
KW - AIDS
KW - bisexuality
KW - blood donors.
KW - homosexuality
KW - human immunodeficiency virus
N1 - Accession Number: 9609130369; Doll, Lynda S. 1 Petersen, Lyle R. 1 White, Carol R. 1 Johnson, Eric S. 1 Ward, John W. 1; Affiliation: 1: Division of HIV/AIDS, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA.; Source Info: Feb92, Vol. 29 Issue 1, p1; Subject Term: MEN -- Sexual behavior; Subject Term: GAY people -- Sexual behavior; Subject Term: HIV-positive persons; Subject Term: HETEROSEXUALS; Subject Term: GAY community; Subject Term: HUMAN sexuality; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: bisexuality; Author-Supplied Keyword: blood donors.; Author-Supplied Keyword: homosexuality; Author-Supplied Keyword: human immunodeficiency virus; Number of Pages: 14p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 5317
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Czaja, Ronald F.
AU - Trunzo, Deborah H.
AU - Royston, Patricia N.
T1 - Response Effects in a Network Survey.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 1992/02//
VL - 20
IS - 3
M3 - Article
SP - 340
SN - 00491241
AB - A reverse record check study was conducted to measure the response effects in a network survey designed to locate a rare population subgroup. In this field experiment, diagnosed cancer patients and certain specified relatives were interviewed using a survey instrument based on the National Health Interview Survey questionnaire and a supplemental set of questions designed to identify persons with cancer. The measurement errors associated with obtaining reports on cancer diagnosis and the date of diagnosis' are presented. In general, high rates of patient identification were found in both patient and relative households; in only 6% of the patient-relative pairs was the patient not reported. Females and Whites were more likely to be reported than males and non-Whites. A significant amount of variation and error in reporting date of diagnosis was found for both the patient and the relative households. Contrary to expectations, most households were likely to backward rather than to forward telescope the date of diagnosis. Suggestions on how to deal with error due to memory factors are proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methods & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - NETWORK analysis (Social sciences)
KW - CANCER patients
KW - CANCER -- Diagnosis
KW - SOCIAL networks
KW - FIELD work (Sociology)
KW - HOUSEHOLD surveys -- Response rate
N1 - Accession Number: 5819475; Czaja, Ronald F. 1 Trunzo, Deborah H. 2 Royston, Patricia N. 3; Affiliation: 1: Associate Professor, Department of Sociology, Anthropology, and Social Work, North Carolina State University. 2: Statistician, Office of Research and Methodology, National Center for Health Statistics. 3: Deputy Director, Division of Information and Analysis, Office of Planning, Evaluation and Legislation of the Health Resources and Services Administration.; Source Info: Feb92, Vol. 20 Issue 3, p340; Subject Term: HEALTH surveys; Subject Term: NETWORK analysis (Social sciences); Subject Term: CANCER patients; Subject Term: CANCER -- Diagnosis; Subject Term: SOCIAL networks; Subject Term: FIELD work (Sociology); Subject Term: HOUSEHOLD surveys -- Response rate; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 27p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sartori, A.
AU - Roque-Barreira, M. C.
AU - Coe, J.
AU - Campos-Neto, A.
T1 - Immune complex glomerulonephritis in experimental kala--azar II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1992/03//
VL - 87
IS - 3
M3 - Article
SP - 386
EP - 392
PB - Wiley-Blackwell
SN - 00099104
AB - In a previous report analysing kidney sections by immunofluorescence we showed that hamsters infected with L. donovani develop a glomerulonephritis (GN) associated with deposition of hamster immunoglobulins and parasite antigens in the glomeruli. In this study we characterize these immune components eluted from the kidneys. The eluted immunoglobulins showed specificity for L. donovani antigens and hamster immunoglobulins (rheumatoid (actor-like activity). The four isotypes IgG1, IgG2, IgA and IgM were detected. Several L. donovani antigens were detected in the renal eluates by Western blot and immuneprecipitation using 125I-labelled eluates. Proteins with mol, wt of 134. 82, 52. 31. and 26 kD were detected by Western blot and proteins with 134. 110, 93, 89 and 48 kD were detected by immunoprecipitation. With the exception of the 134 kD protein which was recognized by both rabbit anti-protnastigote and rabbit anti-amastigote sera all the others were recognized only by the anti-amastigote serum. The 134 kD protein was the only one isolated from the kidneys of infected hamster immunocomplexed with IgG and was the only one detected in a promastigote lysate using IgG from L. donovani-infected hamsters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOFLUORESCENCE
KW - IMMUNOGLOBULINS
KW - RHEUMATOID arthritis
KW - ANTIGENS
KW - IMMUNITY
KW - AGGLUTINATION
KW - experimental kala-azar immune complexes
KW - glomerulonephritis
KW - Leishmania donovani
N1 - Accession Number: 16075014; Sartori, A. 1 Roque-Barreira, M. C. 1 Coe, J. 2 Campos-Neto, A. 1; Affiliation: 1: Department of Immunology, Ribeir&ao Preto Medical School, USP, Brazil. 2: Department of Health, Education and Welfare, Public Health Service, NIH, Hamilton, Montana, USA.; Source Info: Mar1992, Vol. 87 Issue 3, p386; Subject Term: IMMUNOFLUORESCENCE; Subject Term: IMMUNOGLOBULINS; Subject Term: RHEUMATOID arthritis; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Subject Term: AGGLUTINATION; Author-Supplied Keyword: experimental kala-azar immune complexes; Author-Supplied Keyword: glomerulonephritis; Author-Supplied Keyword: Leishmania donovani; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liang, S.-M.
AU - Lee, N.
AU - Finbloom, D.S.
AU - Liang, C.-M.
T1 - Regulation by glutathione of interleukin-4 activity on cytotoxic T cells.
JO - Immunology
JF - Immunology
Y1 - 1992/03//
VL - 75
IS - 3
M3 - Article
SP - 435
EP - 440
PB - Wiley-Blackwell
SN - 00192805
AB - We have previously shown that cellular glutathione (GSH) regulates the T-cell proliferative activity of interleukin-2 (IL-2). Here, we examined whether and how GSH affects the activity of interleukin-4 (IL-4) on murine cytotoxic T cells. CT.4R, a T-cell line that is responsive to both IL-4 and IL-2, was used as a model Although GSH alone had little effect on the thymidine incorporation of CT.4R cells, it enhanced the response of CT.4R to IL-4 and increased the level of thymidine incorporation up to more than 60-fold in a concentration-dependent manner. GSH affected the binding of IL-4 to cellular receptors. Scatchard plot analysis showed that GSH treatment did not change the dissociation constant significantly, however, it increased the receptor number from 1173 ± 126 to 2112 ± 492 molecules per cell. Internalization and degradation studies of IL-4 showed that the amount of IL-4 internalized and degraded in the GSH-treated cells was about twofold higher than those in the cells without GSH treatment. These results suggest that GSH regulates the binding, internalization, degradation and T-cell proliferative activity of IL-4; alteration of cellular GSH levels may thus affect the growth and replication of cytotoxic T cells through growth stimulating cytokines such as IL-2 and IL-4. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - INTERLEUKIN-4
KW - INTERLEUKIN-2
KW - THYMIDINE
KW - CYTOKINES
KW - T cells
N1 - Accession Number: 13395946; Liang, S.-M. 1 Lee, N. 1 Finbloom, D.S. 1 Liang, C.-M. 2; Affiliation: 1: Division of Cytokine Biology, Center for Biologics Evaluation and Research, FDA, Bethesda 2: Molecular Oncology Inc., Gaithersburg, Maryland, U.S.A.; Source Info: Mar1992, Vol. 75 Issue 3, p435; Subject Term: GLUTATHIONE; Subject Term: INTERLEUKIN-4; Subject Term: INTERLEUKIN-2; Subject Term: THYMIDINE; Subject Term: CYTOKINES; Subject Term: T cells; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manohar, V.
AU - Brown, E.M.
AU - Chused, T.M.
T1 - Murine splenic null cell compartment contains distinct haemopoietic subpopulations: enlargement of a myeloid and an indifferentiated subset with the development of splenomegaly in New Zealand black mice.
JO - Immunology
JF - Immunology
Y1 - 1992/03//
VL - 75
IS - 3
M3 - Article
SP - 448
EP - 455
PB - Wiley-Blackwell
SN - 00192805
AB - We have previously reported that non-T, non-B 'null' cells increase with age in New Zealand Black (NZB) mice resulting in splenomegaly. Using a panel of monoclonal antibodies recognizing lineage-specific cell surface antigens we demonstrate four distinct subsets within this null cell compartment: (1) undifferentiated: (2) T lineage with undetectable Thy-1.2; (3) myeloid/erythroid: and (4) a pre-B/ plasma cell type. All four subsets also occur in non-autoimmune mice. The frequency of these populations arc similar in the young mice of all the strains examined, although the total number of null cells is higher in NZB. The elevation of null cells in young NZB mice is controlled by a single dominant gene in the genetic cross with New Zealand White (NZW) mice and does not appear closely related to the subsequent development of autoimmune disease. The proportion of mycloid/erythroid null cells increases with age in NZB as splenomegaly develops. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - MONOCLONAL antibodies
KW - CELL surface antigens
KW - HEMATOPOIETIC system
KW - AUTOIMMUNE diseases
KW - PLASMA cells
N1 - Accession Number: 13395976; Manohar, V. 1 Brown, E.M. 2 Chused, T.M. 2; Affiliation: 1: Laboratory of Cell Biology, Division of Hematology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, National Institute of Health, Bethesda, Maryland, U.S.A. 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.; Source Info: Mar1992, Vol. 75 Issue 3, p448; Subject Term: CELLS; Subject Term: MONOCLONAL antibodies; Subject Term: CELL surface antigens; Subject Term: HEMATOPOIETIC system; Subject Term: AUTOIMMUNE diseases; Subject Term: PLASMA cells; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jackson, Mary E.
AU - Burwell, Brian
AU - Clark, Robert F.
AU - Harahan, Mary
T1 - Eligibility for Publicly Financed Home Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/06//
VL - 82
IS - 6
M3 - Article
SP - 853
EP - 856
PB - American Public Health Association
SN - 00900036
AB - Objectives. Proposals for publicly financed home care for the elderly now tend to include cognitive impairment criteria as well as activities of daily living (ADL) criteria. The numbers of elderly deemed eligible for services will depend on the definitions of ADL and cognitive impairment used. Methods. Data from the 1984 National Long-Term Care Survey were used to generate a series of estimates of the community-dwelling elderly with ADL disabilities and cognitive impairment. Results. When only ADL criteria are used, estimates of disability range from 472 000 to over 3 million (1.6% to 12.5% of the community-dwelling elderly). These estimates increase to approximately 1 million to 4.2 million (3.5% to 14.0% of the community-dwelling elderly) when cognitive impairment criteria are added. Conclusions. The use of more stringent or more liberal eligibility criteria will have dramatic effects on the number of elders who qualify for services. The nature of the eligibility criteria employed in any expansion of federally financed home care benefits will be a major factor in determining the costs of such a program. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOME care services
KW - CONGREGATE housing
KW - MENTAL illness
KW - OLDER people -- Care
KW - MENTALLY ill
N1 - Accession Number: 9207200299; Jackson, Mary E. 1 Burwell, Brian 1 Clark, Robert F. 2 Harahan, Mary 2; Affiliation: 1: SysteMetrics, Lexington, Mass. 2: US Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation, Washington, DC; Source Info: Jun92, Vol. 82 Issue 6, p853; Subject Term: HOME care services; Subject Term: CONGREGATE housing; Subject Term: MENTAL illness; Subject Term: OLDER people -- Care; Subject Term: MENTALLY ill; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; NAICS/Industry Codes: 623312 Assisted Living Facilities for the Elderly; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crane, Nancy T.
AU - Lewis, Christine J.
AU - Yetley, Elizabeth A.
T1 - Do Time Trends in Food Supply Levels of Macronutrients Reflect Survey Estimates of Macronutrient Intake.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/06//
VL - 82
IS - 6
M3 - Article
SP - 862
EP - 866
PB - American Public Health Association
SN - 00900036
AB - Background. Two types of data may be used to estimate trends in food and nutrient intake by the US population: per capita food supply estimates and survey estimates of individual intake. Because these data vary markedly in measurement goals and methods, we examined whether trends in food supply and survey intake estimates for fat, carbohydrate, and protein are reflective of one another. Methods. The data selected for comparison included all available survey estimates of mean intake by the US population (i.e., periodie estimates from 1965 to 1988) and all available per capita food supply estimates from a comparable time period (i.e., annual estimates from 1965 to 1985). Results. The two types of data generally did not reflect the same trends. Furthermore, expressing macronutrient levels as percentage of calories rather than in grams affected the trend relationships. Conclusions. Our findings indicate that caution is needed in the selection and application of available data to estimate trends in macronutrient intake by the US population and in the interpretation of these data with regard to public health research, policies, and programs. [ABSTRACT FROM AUTHOR]
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KW - FOOD supply
KW - CARBOHYDRATES
KW - PROTEINS
KW - FAT
KW - POPULATION
N1 - Accession Number: 9207200302; Crane, Nancy T. 1 Lewis, Christine J. 1 Yetley, Elizabeth A. 1; Affiliation: 1: Food and Drug Administration, US Department of Health and Human Services, Washington, DC; Source Info: Jun92, Vol. 82 Issue 6, p862; Subject Term: FOOD supply; Subject Term: CARBOHYDRATES; Subject Term: PROTEINS; Subject Term: FAT; Subject Term: POPULATION; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parry, Greg E.
AU - Dunn, Paul
AU - Shah, Vinod P.
AU - Pershing, Lynn K.
T1 - Acyclovir Bioavailability in Human Skin.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1992/06//
VL - 98
IS - 6
M3 - Article
SP - 856
EP - 863
SN - 0022202X
AB - Clinical experience demonstrates that oral acyclovir (ACV) is superior to topical ACV in treating recurrent cutaneous herpes simplex virus type 1 (HSV-1) infections. Cutaneous HSV-1 infections are complex in their pathology, affecting the basal epidermis in skin as well as establishing a latency phase in sensory ganglia. In vitro and in vivo human skin model systems were used in the present study to quantitate ACV disposition and absorption in skin and blood following two routes of administration and to investigate whether bioavailability differences were the result of insufficient drug delivery. Physicochemical and physiologic parameters determined from these experiments were used to develop a mathematical model to predict ACV disposition and absorption in human subjects. Model predictions and in vivo data agree; topical administration of commercial 5% ACV ointment and cream result in a 48 times greater total epidermal ACV concentration than after oral administration. Mathematical modeling of the ACV concentration gradient through the epidermis revealed, however, that the drug concentration in the target site of HSV-1 infections, the basal epidermis, is 2-3 times less after topical administration than after oral administration. Thus, the observed lack of clinical efficacy with topical ACV therapy in the recurring HSV-1 infection likely reflects the insufficient delivery of the drug to the target site of the HSV-1 infection, the basal epidermis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACYCLOVIR
KW - BIOAVAILABILITY
KW - SKIN diseases
KW - PATHOLOGY
KW - DOSAGE forms of drugs
KW - OINTMENTS
N1 - Accession Number: 12456948; Parry, Greg E. 1,2,3,4 Dunn, Paul 1,2,3,4 Shah, Vinod P. 1,2,3,4 Pershing, Lynn K. 1,2,3,4; Affiliation: 1: Division of Dermatology, University of Utah, Salt Lake City, Utah. 2: Norwich Eaton Pharmaceutical, P.O. Box 191, WC B46, Norwich, NY 13815. 3: Office of Generic Drugs, Food and Drug Administration, Rockville, Maryland, U.S.A. 4: University of New Mexico, Department of Internal Medicine, Albuquerque, New Mexico.; Source Info: Jun92, Vol. 98 Issue 6, p856; Subject Term: ACYCLOVIR; Subject Term: BIOAVAILABILITY; Subject Term: SKIN diseases; Subject Term: PATHOLOGY; Subject Term: DOSAGE forms of drugs; Subject Term: OINTMENTS; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/1523-1747.ep12456948
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Attfield, Michael D.
AU - Castellan, Robert M.
T1 - Epidemiological Data on US Coal Miners' Pneumoconiosis, 1960 to 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 964
EP - 970
PB - American Public Health Association
SN - 00900036
AB - Objectives. Statistics on prevalence of pneumoconiosis among working underground coal miners based on epidemiological data collected between 1960 and 1988 are presented. The main intent was to examine the time-related trend in prevalence, particularly after 1969, when substantially lower dust levels were mandated by federal act. Methods. Data from studies undertaken between 1960 and 1968 were collected and compared. Information for the period 1969 to 1988 was extracted from a large ongoing national epidemiological study. Tenure-specific prevalence rates and summary statistics derived from the latter data for four consecutive time intervals within the 19-year period were calculated and compared. Results. The results indicate a reduction in pneumoconiosis over time. The trend is similar to that seen in a large radiological surveillance program of underground miners operated concurrently. Conclusions. Although such factors as X-ray reader variation, changes in x-ray standards, and worker self-selection for examination may have influenced the findings to some extent, adjusted summary rates reveal a reduction in prevalence concurrent with reductions in coal mine dust levels mandated by federal act in 1969. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Dust diseases
KW - OCCUPATIONAL diseases
KW - COAL miners
KW - DISEASES
KW - EPIDEMIOLOGY
KW - PUBLIC health
N1 - Accession Number: 9208170775; Attfield, Michael D. 1 Castellan, Robert M. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV; Source Info: Jul1992, Vol. 82 Issue 7, p964; Subject Term: LUNGS -- Dust diseases; Subject Term: OCCUPATIONAL diseases; Subject Term: COAL miners; Subject Term: DISEASES; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Attfield, Michael D.
T1 - British Data on Coal Miners' Pneumoconiosis and Relevance to US Conditions.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 978
EP - 983
PB - American Public Health Association
SN - 00900036
AB - Objectives. The current primary federal dust standard for US underground coal miners of 2 mg/m³ respirable dust is based on British epidemiological information on exposure-response derived in 1969. Since then, much new information has become available. This paper reviews and compares the available information as it relates to the US mining situation. methods. Recent exposure-response information on pneumoconiosis and dust exposure derived by British researchers was employed to estimate working-life risks of pneumoconiosis for miners exposed to 2 mg/m³. Results. It is estimated that close to 9% of underground coal miners who work for 40 years in a 2 mg/m³ environment would develop pneumoconiosis (category 1 or greater). Progressive massive fibrosis would develop in 0.7%. Conclusions. There are unresolved questions relating to the validity of extrapolating findings on British mines and miners to the US and also in predicting disease levels at the low end of the dust exposure spectrum. Given the data available, current information suggests miners who are employed for a working life-time at the current federal dust limit of 2 mg/m³ are still at risk of developing pneumoconiosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Dust diseases
KW - OCCUPATIONAL diseases
KW - COAL miners
KW - EPIDEMIOLOGY
KW - UNITED States
N1 - Accession Number: 9208170777; Attfield, Michael D. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV; Source Info: Jul1992, Vol. 82 Issue 7, p978; Subject Term: LUNGS -- Dust diseases; Subject Term: OCCUPATIONAL diseases; Subject Term: COAL miners; Subject Term: EPIDEMIOLOGY; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siska, Michael
AU - Jason, Janine
AU - Murdoch, Paul
AU - Wen Shan Yang
AU - Donovan, Robert J.
T1 - Recall of AIDS Public Service Announcements and Their Impact on the Ranking of AIDS as a National Problem.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/07//
VL - 82
IS - 7
M3 - Article
SP - 1029
EP - 1032
PB - American Public Health Association
SN - 00900036
AB - The efficacy of two public service announcements from Phase V of the "America Responds to AIDS" (ARTA) campaign was assessed at two sites. Participants were randomly assigned to view a local news program, one with an ARTA public service announcement appearing six times and the other with no AIDS public service announcements. During telephone interviews with 907 participants 1 to 3 nights after viewing, 21% at Site A and 59% at Site B could correctly recall the ARTA public service announcements. Absolute mentions of AIDS as an important national issue increased. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC service advertising
KW - AIDS (Disease)
KW - LOCAL news television programs
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 9208170788; Siska, Michael 1 Jason, Janine 1 Murdoch, Paul 2 Wen Shan Yang 1 Donovan, Robert J. 1; Affiliation: 1: Applied Communications Research and Evaluation, National AIDS Information and Education Program, Centers for Disease Control, Department of Health and Human Services, Public Health Service, Atlanta, Ga. 2: Ogilvy & Mather Advertising, Atlanta.; Source Info: Jul1992, Vol. 82 Issue 7, p1029; Subject Term: PUBLIC service advertising; Subject Term: AIDS (Disease); Subject Term: LOCAL news television programs; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williamson, David F.
AU - Serdula, Mary K.
AU - Anda, Robert F.
AU - Levy, Alan
AU - Byers, Tim
T1 - Weight Loss Attempts in Adults: Goals, Duration, and Rate of Weight Loss.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/09//
VL - 82
IS - 9
M3 - Article
SP - 1251
EP - 1251
PB - American Public Health Association
SN - 00900036
AB - Objectives: Although attempted weight loss is common, little is known about the goals and durations of weight loss attempts and the rates of achieved weight loss in the general population. Methods. Data were collected by telephone in 1989 from adults aged 18 years and older in 39 states and the District of Columbia. Analyses were carried out separately for the 6758 men and 14,915 women who reported currently trying to lose weight. Results. Approximately 25% of the men respondents and 40% of the women respondents reported that they were currently trying to lose weight. Among men, a higher percentage of Hispanics (31%) than of Whites (25%) or Blacks (23%) reported trying to lose weight. Among women, however, there were no ethnic differences in prevalence. The average man wanted to lose 30 pounds and to weigh 178 pounds; the average woman wanted to lose 31 pounds and to weigh 133 pounds. Black women wanted to lose an average of 8 pounds more than did White women, but Black women's goal weight was 10 pounds heavier. The average rate of achieved weight loss was 1.4 pounds per week for men and 1.1 pounds per week for women; these averages, however, may reflect only the experience of those most successful at losing weight. Conclusions. Attempted weight loss is a common behavior, regardless of age, gender, or ethnicity, and weight loss goals are substantial; however, obesity remains a major public health problem in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEIGHT loss
KW - REDUCING diets
KW - OBESITY
KW - PUBLIC health
KW - WASHINGTON (D.C.)
N1 - Accession Number: 9212212221; Williamson, David F. 1 Serdula, Mary K. 1 Anda, Robert F. 1 Levy, Alan 2 Byers, Tim 1; Affiliation: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, Ga. 2: Division of Consumer Studies, Food and Drug Administration, Washington, DC; Source Info: Sep92, Vol. 82 Issue 9, p1251; Subject Term: WEIGHT loss; Subject Term: REDUCING diets; Subject Term: OBESITY; Subject Term: PUBLIC health; Subject Term: WASHINGTON (D.C.); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garrison, David L.
AU - Conrad, Steve M.
AU - Eilers, Paul P.
AU - Waldron, Ellen M.
T1 - CONFIRMATION OF DOMOIC ACID PRODUCTION BY PSEUDONITZSCHIA AUSTRALIS (BACILLARIOPHYCEAE) CULTURES.
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 1992/10//
VL - 28
IS - 5
M3 - Article
SP - 604
EP - 607
SN - 00223646
AB - Single clone isolates of Pseudonitzschia australis Frenguelli(= Nitzschia pseudoseriata Hasle) isolated from a toxic bloom in Monterey Bay, California produced domoic acid in culture. Although long-term historical records do not indicate previous blooms of this species on the Pacific coast, this is probably because it has been often misidentified as Nitzchia seriata Hasle; previous evidence for toxicity is lacking. Hydrographic data suggest that areas such as Monterey Bay might be" hot spots" for domoic acid-producing blooms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALGAL blooms
KW - DIATOMS
KW - HYDROGRAPHY
KW - MONTEREY Bay (Calif.)
KW - CALIFORNIA
KW - UNITED States
KW - Amnesic shellfish poisoning
KW - Bacillariophyceae
KW - domoic acid
KW - Nitzschia pseudoseriatsa
KW - Pseudonitzschia australis
KW - toxic blooms
N1 - Accession Number: 10780640; Garrison, David L. 1 Conrad, Steve M. 2 Eilers, Paul P. 2 Waldron, Ellen M. 2; Affiliation: 1: Institute of Marine Sciences, University of California, Santa Cruz, California 95064. 2: U. S. Food and Drug Administration, Office of Seafood, HFF 520, 200 C. St. Southwest, Washington, D. C. 20204.; Source Info: Oct92, Vol. 28 Issue 5, p604; Subject Term: ALGAL blooms; Subject Term: DIATOMS; Subject Term: HYDROGRAPHY; Subject Term: MONTEREY Bay (Calif.); Subject Term: CALIFORNIA; Subject Term: UNITED States; Author-Supplied Keyword: Amnesic shellfish poisoning; Author-Supplied Keyword: Bacillariophyceae; Author-Supplied Keyword: domoic acid; Author-Supplied Keyword: Nitzschia pseudoseriatsa; Author-Supplied Keyword: Pseudonitzschia australis; Author-Supplied Keyword: toxic blooms; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/1529-8817.ep10780640
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Selevan, Sherry
AU - Landrigan, Philip
T1 - The Mortality of Lead Smelter Workers: An Update.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1992/12//
VL - 82
IS - 12
M3 - Article
SP - 1641
EP - 1644
PB - American Public Health Association
SN - 00900036
AB - Objectives. Mortality studies of lead workers have shown excesses of nonmalignant renal disease and cerebrovascular disease. Animal studies and one human study have shown excess kidney cancer. We have updated a mortality study of male lead smelter workers (n = 1990). Methods. An analysis was conducted using standard life table techniques. The updated analysis added 11 years of follow-up and 363 new deaths. Results. The original study had found elevated but nonsignificant risks for kidney cancer, stroke, and nonmalignant renal disease, probably attributable to lead exposure. Deaths from accidents and nonmalignant respiratory disease were significantly elevated, but probably not as a result of lead exposure. In the updated study, no new deaths from nonmalignant renal disease occurred (9 observed, standardized mortality ratio = 1.21). Three more deaths from kidney cancer were observed, yielding a standardized mortality ratio of 1.93 (9 observed, 95% CI = 0.88, 3.67), which increased for those who had worked in areas with the highest lead exposure (8 observed, standardized mortality ratio = 2.39, 95% CI = 1.03, 4.71). Cerebrovascular disease remained elevated for those with more than 20 years of exposure (26 observed, standardized mortality ratio = 1.41, 95% CI = 0.92, 2.07). Conclusions. This cohort with high lead exposure showed a diminishing excess of death from nonmalignant renal disease, a continued excess from kidney cancer, and an excess of cerebrovascular disease only in those with longest exposure to lead. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - LEAD smelting
KW - EMPLOYEES
KW - KIDNEY diseases
KW - CEREBROVASCULAR disease
KW - KIDNEYS -- Cancer
KW - DEATH
N1 - Accession Number: 9306166053; Steenland, Kyle 1 Selevan, Sherry 2 Landrigan, Philip 3; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: Environmental Protection Agency, Washington, DC 3: Mount Sinai School of Medicine, New York, NY; Source Info: Dec1992, Vol. 82 Issue 12, p1641; Subject Term: MORTALITY; Subject Term: LEAD smelting; Subject Term: EMPLOYEES; Subject Term: KIDNEY diseases; Subject Term: CEREBROVASCULAR disease; Subject Term: KIDNEYS -- Cancer; Subject Term: DEATH; NAICS/Industry Codes: 331410 Nonferrous Metal (except Aluminum) Smelting and Refining; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sanchez, Maria Elena
AU - Morchio, Giovanna
T1 - Probing "don't know" answers.
JO - Public Opinion Quarterly
JF - Public Opinion Quarterly
Y1 - 1992///Winter92
VL - 56
IS - 4
M3 - Article
SP - 454
SN - 0033362X
AB - Don't Know responses to survey questions are ambiguous because the same words are used by respondents to mean different things-ignorance, indecision, or uncertainty about the meaning of the question asked. In order to clarify the meaning of such answers, survey interviewers are frequently trained to probe Don't Know answers at least once before the answer is considered final. We argue that unconditional probing of Don't Know answers may not be a desirable practice, particularly as regards knowledge items. Large unintended effects on responses to four knowledge items resulted when two groups of interviewers, who administered the same survey questions, probed Don't Know responses at different rates. Strong evidence is provided in the article that the probing of Don't Know answers encouraged guesswork on the part of uninformed respondents, giving rise to significant distributional differences and differences in means across half samples for the affected variables. However, relationships between variables appear to be largely unaffected by probing effects. In order to formulate valid probing guidelines for interviewer training, further research is needed to establish whether the findings for knowledge questions generalize to factual questions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Opinion Quarterly is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURVEYS
KW - MEANING (Philosophy)
KW - DECISION making
KW - UNCERTAINTY
KW - INTERVIEWING
KW - TRAINING
N1 - Accession Number: 9409081061; Sanchez, Maria Elena 1 Morchio, Giovanna 2; Affiliation: 1: Survey methodologist, Agency for Health Care Policy and Research, U.S. Public Health Service. 2: Research associate, Institute for Social Research, University of Michigan.; Source Info: Winter92, Vol. 56 Issue 4, p454; Subject Term: SURVEYS; Subject Term: MEANING (Philosophy); Subject Term: DECISION making; Subject Term: UNCERTAINTY; Subject Term: INTERVIEWING; Subject Term: TRAINING; Number of Pages: 21p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lehman, Paul A.
AU - Franz, Thomas J.
T1 - Effect of Age and Diet on Stratum Corneum Barrier Function in the Fischer 344 Female Rat.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1993/02//
VL - 100
IS - 2
M3 - Article
SP - 200
EP - 204
SN - 0022202X
AB - Stratum corneum barrier function in the female Fischer 344 rat was assessed in animals ranging from 11 to 144 weeks of age, which were either fed ad libitum or a caloric-restricted diet at 60% ad libitum Caloric restriction has been shown to increase the life span of rodents and delay age-associated degenerative diseases. The penetration of Water, lidocaine, and hydrocortisone were measured in vitro using the finitedose technique in Franz diffusion chambers. Water permeability did not significantly change with either age or diet condition (with the single exception of the ad libitum 144week animals). However, between 11 and 44 weeks, both lidocaine and hydrocortisone permeability increased with age in both diet groups. By 44 weeks the caloric restriction animals had significantly greater permeability to lidocaine and hydrocortisone then their ad libitum age cohorts. Between 44 and 144 weeks, skin permeability in the ad libitum animals, continued to increase with age, whereas permeability in the caloric restriction animals declined. By 144 weeks the caloric restriction skin was less permeable than the age-matched ad libitum animals but still more permeable than the I 1-week animals. The data show that the barrier properties of stratum corneum change with age in the female rat and that this change can be modulated by caloric restriction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEGENERATION (Pathology)
KW - DISEASES
KW - AGE
KW - DIET
KW - RODENTS
KW - FOOD
N1 - Accession Number: 12462809; Lehman, Paul A. 1,2 Franz, Thomas J. 1,2; Affiliation: 1: National Center for Toxicological Research, Jefferson 2: University of Arkansas for Medical Sciences, Department of Dermatology, Little Rock, Arkansas; Source Info: Feb93, Vol. 100 Issue 2, p200; Subject Term: DEGENERATION (Pathology); Subject Term: DISEASES; Subject Term: AGE; Subject Term: DIET; Subject Term: RODENTS; Subject Term: FOOD; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/1523-1747.ep12462809
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johansson, A.
AU - Haraldson, T.
AU - Omar, R.
AU - Kiliaridis, S.
AU - Carlsson, G. E.
T1 - A system for assessing the severity and progression of occlusal tooth wear.
JO - Journal of Oral Rehabilitation
JF - Journal of Oral Rehabilitation
Y1 - 1993/03//
VL - 20
IS - 2
M3 - Article
SP - 125
EP - 131
SN - 0305182X
AB - This study represents an attempt to introduce a system for the longitudinal evaluation of the severity and the rate of progression of tooth wear. The material comprised a selected group of 10 males and 10 females, examined twice within an 18-month period. The subjects were predisposed to advanced occlusal wear and had a mean age of 32 years within the range of 16-56 years. Evaluation of occlusal wear was performed on a tooth-by-tooth basis, on study casts, using two ordinal scales, one for assessing the severity, and the other the progression of occlusal wear. The reliability of the scales was assessed by percentage inter-observer concordances. The sample exhibited higher occlusal wear scores in the incisor and canine regions compared to the posterior region. It was found that the overall progression in an 18-month follow-up period was slow. The inter-observer concordance in the evaluation of the severity of wear was 88%, and 91% in the progression of wear. Within the limitations of the described system, the scales may be utilized for determining the severity of occlusal wear and the rate of its deterioration in an individual's dentition. From a clinical standpoint, the need for future treatment may be based on such an evaluation of the progression of wear. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Oral Rehabilitation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCLUSAL adjustment
KW - TEETH
KW - DENTITION (Tooth development)
KW - PEDIATRIC physiology
KW - CUSPIDS
KW - DENTAL care
N1 - Accession Number: 13454727; Johansson, A. 1,2 Haraldson, T. 3 Omar, R. 4 Kiliaridis, S. 5 Carlsson, G. E. 2; Affiliation: 1: Department of Restorative Dental Sciences, King Saud University Riyadh. 2: Department of Prosthetic Dentistry, University of Göteborg. 3: Department of Stomatognathic Physiology, Public Health Service, Borås. 4: Department of Dentistry, Armed Forces Hospital Riyadh. 5: Department of Orthodontics, University of Göteborg.; Source Info: Mar1993, Vol. 20 Issue 2, p125; Subject Term: OCCLUSAL adjustment; Subject Term: TEETH; Subject Term: DENTITION (Tooth development); Subject Term: PEDIATRIC physiology; Subject Term: CUSPIDS; Subject Term: DENTAL care; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/1365-2842.ep13454727
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zarkin, Gary A.
AU - Dean, Nancy
AU - Mauskopf, Josephine A.
AU - Williams, Richard
T1 - Potential Health Benefits of Nutrition Label Changes.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/05//
VL - 83
IS - 5
M3 - Article
SP - 717
EP - 724
PB - American Public Health Association
SN - 00900036
AB - OBJECTIVES. The Nutrition Labeling and Education Act of 1990 mandates the Food and Drug Administration to promulgate changes in nutrition labeling regulations. This study investigates the potential health benefits associated with expected changes in food consumption resulting from the act. METHODS. This paper provides four estimates of the potential health benefits from the dietary changes expected to occur as a result of the 1990 act. The upper bound estimates begin with the premise that all consumers will adopt the daily reference values of total fat, saturated fat, and cholesterol. The lower bound estimate is based on consumers' responses to a shelf-labeling program sponsored by the Food and Drug Administration in the 1980s. A computer model developed by Dr. Warren Browner and his associates was used to estimate the health benefits from reduced nutrient intakes. RESULTS. Estimates of the number of discounted life-years gained nationwide for the first 20 years after the implementation of the act range from a high of 1.2 million to a low of 40,000. CONCLUSIONS. The results of the study highlight that relatively small changes in nutrient intakes may generate large public health benefits. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LABELS -- Law & legislation
KW - FOOD labeling
KW - NUTRITION
KW - FOOD consumption
KW - PUBLIC health
N1 - Accession Number: 9307095130; Zarkin, Gary A. 1 Dean, Nancy 1 Mauskopf, Josephine A. 2 Williams, Richard 3; Affiliation: 1: Center for Economics Research, Research Triangle Institute, Research Triangle Park, NC 2: Burroughs Wellcome, Research Triangle Park, NC 3: Food and Drug Administration, Washington, DC; Source Info: May93, Vol. 83 Issue 5, p717; Subject Term: LABELS -- Law & legislation; Subject Term: FOOD labeling; Subject Term: NUTRITION; Subject Term: FOOD consumption; Subject Term: PUBLIC health; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wysowski, Diane K.
AU - Baum, Carlene
T1 - Validity of Medicaid Diagnoses of Hip Fracture.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/05//
VL - 83
IS - 5
M3 - Letter
SP - 770
EP - 770
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to an article about the validity of Medicaid diagnoses of hip fracture.
KW - LETTERS to the editor
KW - FRACTURES
N1 - Accession Number: 9307095146; Wysowski, Diane K. 1 Baum, Carlene; Affiliation: 1: Division of Epidemiology and Surveillance, Food and Drug Administration, HFD-733, Rockville, MD 20857; Source Info: May93, Vol. 83 Issue 5, p770; Subject Term: LETTERS to the editor; Subject Term: FRACTURES; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marconi, Katherine M.
AU - Pruzan, Marcia
AU - Johnson, Annette M.
T1 - New York City's Metropolitan Area Breast Cancer Awareness Partnership.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/06//
VL - 83
IS - 6
M3 - Article
SP - 905
EP - 907
PB - American Public Health Association
SN - 00900036
AB - The article deals with the Metropolitan Area Breast Cancer Awareness Partnership program in New York City. The partnership consisted of many health organizations including the National Cancer Institute and the National Alliance of Breast Cancer Organizations. Initial assignments to program subcommittees include developing a packet of information materials to be distributed to all participants. The second Annual Breast Cancer Awareness Month Breakfast on October 22, 1991 was sponsored by the partnership.
KW - BREAST cancer
KW - CANCER prevention
KW - HEALTH education
KW - ASSOCIATIONS, institutions, etc.
KW - METROPOLITAN areas
KW - NEW York (N.Y.)
KW - NEW York (State)
N1 - Accession Number: 9308046306; Marconi, Katherine M. 1 Pruzan, Marcia 2 Johnson, Annette M. 2; Affiliation: 1: Bureau of Health Resources Development, HRSA, Public Health Service, Room 1111, Rockville, MD 20857 2: Bureau of Health Resources Development, HRSA., Public Health Service, Room 1111, Rockville, MD 20857.; Source Info: Jun93, Vol. 83 Issue 6, p905; Subject Term: BREAST cancer; Subject Term: CANCER prevention; Subject Term: HEALTH education; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: METROPOLITAN areas; Subject Term: NEW York (N.Y.); Subject Term: NEW York (State); NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waldman, Robert
T1 - Winning the Peace: The Strategic Implications of Military Civic Action.
JO - Armed Forces & Society (0095327X)
JF - Armed Forces & Society (0095327X)
Y1 - 1993///Summer93
VL - 19
IS - 4
M3 - Book Review
SP - 642
EP - 644
PB - Sage Publications Inc.
SN - 0095327X
AB - The article reviews the book "Winning the Peace: The Strategic Implications of Military Civic Action," edited by John W. De Pauw and George A. Luz.
KW - MILITARY civic action
KW - NONFICTION
KW - DE Pauw, John W.
KW - LUZ, George A.
KW - WINNING the Peace: The Strategic Implications of Military Civic Action (Book)
N1 - Accession Number: 9311240039; Waldman, Robert 1; Affiliation: 1: U.S. Public Health Service Washington, DC; Source Info: Summer93, Vol. 19 Issue 4, p642; Subject Term: MILITARY civic action; Subject Term: NONFICTION; Reviews & Products: WINNING the Peace: The Strategic Implications of Military Civic Action (Book); People: DE Pauw, John W.; People: LUZ, George A.; Number of Pages: 3p; Document Type: Book Review; Full Text Word Count: 736
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bright, Roselie A.
AU - Moore Jr., Roscoe M.
AU - Jeng, Lana L.
AU - Sharkness, Casherine M.
AU - Hamburger, Stanford E.
AU - Hamilton, Peggy M.
T1 - The Prevalence of Tympanostomy Tubes in Children in the United States, 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/07//
VL - 83
IS - 7
M3 - Article
SP - 1026
EP - 1028
PB - American Public Health Association
SN - 00900036
AB - Information from the 1988 National Health Interview Survey Medical Device Implant Supplement was used to obtain the first population estimates of the prevalence of implanted tympanostomy tubes, a common treatment for otitis media. The prevalence rate was estimated to be 13 per 1000 children aged younger than 18 years. Statistically significant differences in prevalence were found for sex (boys, 15/1000; girls, 10/1000), race (Whites, 15/1000; others, 4/1000), and activity level ("limited," 44/1000; others 11/1000). Thirty percent of the tubes were replacements; infection was the reason for 75% of the original implants. The morbidity and costs associated with tympanostomy tubes are of public health importance. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OTITIS media
KW - ARTIFICIAL implants
KW - DISEASES
KW - PUBLIC health
KW - MIDDLE ear -- Diseases
KW - BIOMEDICAL materials
N1 - Accession Number: 9309075213; Bright, Roselie A. 1 Moore Jr., Roscoe M. 1 Jeng, Lana L. 1 Sharkness, Casherine M. 1 Hamburger, Stanford E. 1 Hamilton, Peggy M. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md; Source Info: Jul1993, Vol. 83 Issue 7, p1026; Subject Term: OTITIS media; Subject Term: ARTIFICIAL implants; Subject Term: DISEASES; Subject Term: PUBLIC health; Subject Term: MIDDLE ear -- Diseases; Subject Term: BIOMEDICAL materials; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore Jr., Roscoe M.
AU - Bright, Roselie A.
AU - Jeng, Lana L.
AU - Sharkness, Catherine M.
AU - Hamburger, Stanford E.
AU - Hamilton, Peggy M.
T1 - The Prevalence of Internal Orthopedic Fixation Devices in Children in the United States, 1988.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/07//
VL - 83
IS - 7
M3 - Article
SP - 1028
EP - 1030
PB - American Public Health Association
SN - 00900036
AB - This study provides the first estimated prevalence of implanted orthopedic fixation devices (e.g., pins or wires) among children in the United States, based on the Medical Device Implant Supplement to the 1988 National Health Interview Survey. The overall prevalence was 27 per 10 000 children younger than 18 years; prevalence was highest (59/10 000) among those aged 12 to 17 years. The lower extremities were the most frequent body site (43%) and injury was the leading specific reason for implantation (37%). Some (10%) were replacement implants. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - ARTIFICIAL implants
KW - BIOMEDICAL engineering
KW - BIOMEDICAL materials
KW - MEDICAL supplies
KW - SURGERY
N1 - Accession Number: 9309075214; Moore Jr., Roscoe M. 1 Bright, Roselie A. 1 Jeng, Lana L. 1 Sharkness, Catherine M. 1 Hamburger, Stanford E. 1 Hamilton, Peggy M. 1; Affiliation: 1: Center fox Devices and Radiological Health, Food and Drug Administration, Rockville, Md; Source Info: Jul1993, Vol. 83 Issue 7, p1028; Subject Term: MEDICAL equipment; Subject Term: ARTIFICIAL implants; Subject Term: BIOMEDICAL engineering; Subject Term: BIOMEDICAL materials; Subject Term: MEDICAL supplies; Subject Term: SURGERY; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 3p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gfroerer, Joseph C.
AU - Brodsky, Marc D.
T1 - Frequent Cocaine Users and Their Use of Treatment.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/08//
VL - 83
IS - 8
M3 - Article
SP - 1149
EP - 1149
PB - American Public Health Association
SN - 00900036
AB - Objectives. Despite decreases in the number of cocaine users since 1985, the consequences of cocaine use continue to rise. This paper provides descriptive data on frequent cocaine users that will help to explain these diverging trends and enable treatment planners to better predict the types of cocaine users who are likely to seek treatment. Methods. Data from the National Household Survey on Drug Abuse were used to study the characteristics of frequent cocaine users since 1985. The 1991 data were used to compare frequent users with infrequent users and nonusers. Results. Since 1985, frequent cocaine users have become older. In 1991, they were likely to be unemployed (32.4%), unmarried (82.3%), and without health insurance (39.4%). Most were cigarette smokers (86.8%) and marijuana users (88.4%), and 32.0% reported getting drunk weekly. Criminal behavior was more likely among frequent cocaine users than among infrequent users and nonusers. Almost a third (30.0%) reported drug abuse treatment experience in the past year. Conclusions. Despite the recent decreases in overall prevalence of cocaine use, the need for treatment of cocaine abusers will continue. Treatment must address multiple problems that occur in conjunction with cocaine abuse. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Treatment
KW - COCAINE
KW - NARCOTICS
KW - COCAINE abuse
KW - HOUSEHOLD surveys
KW - THERAPEUTICS
N1 - Accession Number: 9312091182; Gfroerer, Joseph C. 1 Brodsky, Marc D.; Affiliation: 1: Substance Abuse and Mental Health Services Administration, Rockville, Md.; Source Info: Aug1993, Vol. 83 Issue 8, p1149; Subject Term: DRUG abuse -- Treatment; Subject Term: COCAINE; Subject Term: NARCOTICS; Subject Term: COCAINE abuse; Subject Term: HOUSEHOLD surveys; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hisnanick, John J.
AU - Erickson, Patricia M.
T1 - Hospital Resource Utilization by American Indians/Alaska Natives for Alcoholism and Alcohol Abuse.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1993/09//
VL - 19
IS - 3
M3 - Article
SP - 387
EP - 396
SN - 00952990
AB - Previous work examining the issue of alcoholism and alcohol abuse among American Indians and Alaska Natives can be broadly categorized as either descriptions of the consumption patterns and behaviors of specific tribes or mortality studies, focusing on deaths due to alcoholism, alcohol abuse, chronic liver disease, or cirrhosis. A major shortcoming of previous studies has been that they have not looked at the burden this problem has imposed upon the system of health care delivery for this minority population. By using an International Classification of Diseases, Ninth Revision, Clinical Modification taxonomy of diagnostic codes developed by the National Institute on Alcoholism and Alcohol Abuse (NIAAA) and the national Indian Health Service (IHS) inpatient database for direct and contract admissions, utilization patterns for 43 IHS facilities were investigated. The period of study was 1980-1988, and our case definition included any individual 14 years and older who had any mention upon discharge of an alcohol-related diagnosis (ARD). For the 9-year period under investigation, 43,302 adult inpatient admissions occurred at the 43 IHS facilities for ARD. These admissions accounted for an overall estimated per annum rate of 13.7% of the adult inpatient days. In addition, age and gender specific discharge rates for ARD were estimated and compared to reported ARD discharge rates of the United States civilian population prepared by the NIAAA using the National Hospital Discharge Survey over the period 1979-1988. In contrast, the IHS discharge rates for ARD were three times greater than reported ARD discharge rates for the United States civilian population [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE Americans
KW - ALCOHOLISM
KW - CONTROLLED drinking
KW - SUBSTANCE abuse
KW - DRUG abuse
KW - ADDICTIONS
N1 - Accession Number: 9409010050; Hisnanick, John J. 1 Erickson, Patricia M. 1; Affiliation: 1: Indian Health Service, Office cf Health Programs Research and Development U.S. Department of Health and Human Services 7900 S. J. Stock Rd., Tucson, Arizona 85746.; Source Info: 1993, Vol. 19 Issue 3, p387; Subject Term: NATIVE Americans; Subject Term: ALCOHOLISM; Subject Term: CONTROLLED drinking; Subject Term: SUBSTANCE abuse; Subject Term: DRUG abuse; Subject Term: ADDICTIONS; Number of Pages: 10p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubin, Carol Hogfoss
AU - Burnett, Carol A.
AU - William E. Halperin
AU - Seligman, Paul J.
T1 - Occupation as a Risk Identifier for Breast Cancer.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/09//
VL - 83
IS - 9
M3 - Article
SP - 1311
EP - 1315
PB - American Public Health Association
SN - 00900036
AB - Objectives. Breast cancer mortality may be reduced if the disease is detected early through targeted screening programs. Current screening guidelines are based solely on a woman's age. Because working populations are accessible for intervention, occupational identification may be a way of helping to define and locate risk groups and target prevention. Methods. We used a database consisting of 2.9 million occupationally coded death certificates collected from 23 states between 1979 and 1987 to calculate age-adjusted, race-specific proportionate mortality ratios for breast cancer according to occupation. We performed case-control analyses on occupational groups and on stratifications within the teaching profession. Results. We found a number of significant associations between occupation and frequency of breast cancer. For example, white female professional, managerial, and clerical workers all had high proportions of breast cancer death. High rates of breast cancer in teachers were found in both proportionate mortality ratio and case-control analyses. Conclusions. These findings may serve as in an aid in the effective targeting of work-site health promotion programs. They suggest that occupationally coded mortality data can be a useful adjunct in the difficult task of identifying groups at risk of preventable disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - MEDICAL screening
KW - EMPLOYEE health promotion
KW - OCCUPATIONAL diseases
KW - MORTALITY
N1 - Accession Number: 9401110384; Rubin, Carol Hogfoss 1 Burnett, Carol A. 1 William E. Halperin 1 Seligman, Paul J. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Source Info: Sep93, Vol. 83 Issue 9, p1311; Subject Term: BREAST cancer; Subject Term: MEDICAL screening; Subject Term: EMPLOYEE health promotion; Subject Term: OCCUPATIONAL diseases; Subject Term: MORTALITY; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McNeely, M. Carol
AU - Lawley, Thomas J.
AU - Harvath, Liana
T1 - Monoclonal Antibody Modulates Human Neutrophil Chemotaxis to N-formyl-Methionyl-Leucyl-Phenylalanine (fMLP).
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1993/09//
VL - 101
IS - 3
M3 - Article
SP - 377
EP - 382
SN - 0022202X
AB - Utilizing standard hybridoma techniques and a neutrophil chemotaxis assay for screening we produced a mouse monoclonal IgM antibody, 59/4, selected for specific inhibition of human neutrophil chemotaxis to the N-formyl-methionyleucyl- phenylalanine peptide (fMLP). Antibody 59/4 inhibited neutrophil chemotaxis to fMLP, but not human C5a or leukotriene B4. The antibody exhibited specific homogeneous binding to PMNs, heterogeneous binding to monocytes, and did not bind to lymphocytes in a pattern similar to the profile of N-formyl peptide binding in flow cytometric analysis. The antibody did not inhibit the binding of fluorescein-conjugated fMLPK or fML(³H)P ligands to neutrophils in flow cytometric or competitive binding assays. Other neutrophil functions including mycloperoxidase release and rosette formation with immunoglobulin or immunoglobulin C3b-coated sheep erythrocytes were not affected in the presence of antibody 59/4. These results suggest that 59/4 specifically inhibits chemotaxis to fMLP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYBRIDOMAS
KW - CHEMOTAXIS
KW - PEPTIDES
KW - MONOCYTES
KW - IMMUNOGLOBULINS
KW - BINDING sites (Biochemistry)
N1 - Accession Number: 12365592; McNeely, M. Carol 1 Lawley, Thomas J. 2 Harvath, Liana 3; Affiliation: 1: Dermatology Branch, National Cancer Institute, National Institute of Health, Atlanta, Georgia. 2: Department of Dermatology, Emory University, Atlanta, Georgia. 3: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, U.S.A.; Source Info: Sep93, Vol. 101 Issue 3, p377; Subject Term: HYBRIDOMAS; Subject Term: CHEMOTAXIS; Subject Term: PEPTIDES; Subject Term: MONOCYTES; Subject Term: IMMUNOGLOBULINS; Subject Term: BINDING sites (Biochemistry); Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1523-1747.ep12365592
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Stout, Nancy
T1 - The Methodology of Fatal Occupational Injury Surveillance.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/10//
VL - 83
IS - 10
M3 - Letter
SP - 1492
EP - 1492
PB - American Public Health Association
SN - 00900036
AB - A response by Nancy Stout to a letter to the editor about his article on methods of conducting fatal occupational injury surveillance is presented.
KW - LETTERS to the editor
KW - INVESTIGATIONS
N1 - Accession Number: 19889612; Stout, Nancy 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, 944 Chestnut Ridge Rd, Morgantown, WV 26505; Source Info: Oct93, Vol. 83 Issue 10, p1492; Subject Term: LETTERS to the editor; Subject Term: INVESTIGATIONS; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trickett, Edison J.
AU - Watts, Roderick
AU - Birman, Dina
T1 - Human Diversity and Community Psychology: Still Hazy After All These Years.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1993/10//
VL - 21
IS - 4
M3 - Article
SP - 264
EP - 279
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - This paper explores the relationship between community psychology and its commitment to issues of human diversity. It is argued that the evolving conception of diversity and the emergence of contextualist/constructionist philosophies of science provide an opportunity to integrate human diversity into research and practice in community psychology. The history of community psychology's involvement with issues of human diversity is outlined, and an ecological perspective is offered as one framework for incorporating diversity issues into the field. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY psychology
KW - ETHNICITY
KW - HUMAN ecology
KW - MINORITIES
KW - SOCIAL psychology
KW - APPLIED psychology
N1 - Accession Number: 11988501; Trickett, Edison J. 1 Watts, Roderick 2 Birman, Dina 3; Affiliation: 1: University of Maryland. 2: DePaul University. 3: Refugee Mental Health Branch, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration.; Source Info: Oct93, Vol. 21 Issue 4, p264; Subject Term: COMMUNITY psychology; Subject Term: ETHNICITY; Subject Term: HUMAN ecology; Subject Term: MINORITIES; Subject Term: SOCIAL psychology; Subject Term: APPLIED psychology; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nutting, Paul A.
AU - Freeman, William L.
AU - Risser, David R.
AU - Helgerson, Steven D.
AU - Paisano, Roberta
AU - Hisnanick, John
AU - Beaver, Shelli K.
AU - Peters, Irene
AU - Carney, John P.
AU - Speers, Marjorie A.
T1 - Cancer Incidence among American Indians and Alaska Natives, 1980 through 1987.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/11//
VL - 83
IS - 11
M3 - Article
SP - 1589
EP - 1598
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study uses Indian Health Service inpatient data to estimate cancer incidence among American Indians and Alaska Natives. Methods. Hospital discharge data for 1980 through 1987 were used to identify cases of cancer for 21 sites in women and 18 sites in men. Estimates of incidence were directly standardized to data from the Surveillance, Epidemiology, and End Results Program for the same time frame. Results. Cancers of the gallbladder, kidney, stomach, and cervix show generally high rates among many American Indian and Alaska Native communities, and cancers of the liver and nasopharynx are high in Alaska. Of the relatively common cancers in Whites, American Indians and Alaska Natives experience lower rates for cancers of the breast, uterus, ovaries, prostate, lung, colon, rectum, and urinary bladder and for leukemia and melanoma. Variation among geographic areas and among tribal groups is observed for many important cancer sites. Conclusions. This study demonstrates significant variations of cancer rates among American Indians and Alaska Natives, with important implications for Indian Health Service cancer control programs. The study also supports the potential use of hospital discharge data for estimating chronic disease among diverse American Indian and Alaska Native communities. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE Americans -- Health
KW - GALLBLADDER -- Cancer
KW - KIDNEYS -- Cancer
KW - STOMACH -- Cancer
KW - CERVICAL cancer
KW - LIVER -- Cancer
KW - NASOPHARYNX
KW - UNITED States. Indian Health Service
N1 - Accession Number: 9402235305; Nutting, Paul A. 1,2 Freeman, William L. 3 Risser, David R. 4 Helgerson, Steven D. 5 Paisano, Roberta 6 Hisnanick, John 3 Beaver, Shelli K. 7 Peters, Irene 7 Carney, John P. 3 Speers, Marjorie A. 8; Affiliation: 1: Ambulatory Sentinel Practice Network 2: Department of Family Medicine, University of Colorado Health Sciences Center, Denver 3: Office of Health Program Research and Development, Indian Health Services, Tucson, Ariz. 4: Division of Medical System Research and Development, Office of Health Program Research and Development, Albuquerque, NM 5: Health Care Financing Administration, Seattle, Wash. 6: Cancer Prevention and Control Program, Indian Health Service Headquarters West, Albuquerque, NM 7: Research Program, Indian Health Service, Albuquerque, NM 8: Division of Chronic Disease Control and Community Intervention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Ga.; Source Info: Nov93, Vol. 83 Issue 11, p1589; Subject Term: NATIVE Americans -- Health; Subject Term: GALLBLADDER -- Cancer; Subject Term: KIDNEYS -- Cancer; Subject Term: STOMACH -- Cancer; Subject Term: CERVICAL cancer; Subject Term: LIVER -- Cancer; Subject Term: NASOPHARYNX; Company/Entity: UNITED States. Indian Health Service; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nwanyanwu, Okey C.
AU - Chu, Susan Y.
AU - Green, Timothy A.
AU - Buehler, James W.
AU - Berkelman, Ruth L.
T1 - Acquired Immunodeficiency Syndrome in the United States Associated with Injecting Drug Use, 1981-1991.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1993/12//
VL - 19
IS - 4
M3 - Article
SP - 399
EP - 408
SN - 00952990
AB - As of June 30, 1991, 182, 834 AIDS cases in the United States had been reported to the Centers for Disease Control, of which 58.879 (32.2%) were associated with illicit drug use. Of these, 39,904 (70.0%) were in both women and heterosexual men reported as injecting drug users (IDUs), 11.823 (20.7%) in men who have sex with men who are also IDUs, 5,305 (9.3%) in sex partners of IDUs, and 1,847 (3.1 %) in children whose mothers were either IDUs or sex partners of IDUs. From 1989 to 1990, the increase in the number of United States AIDS cases associated with IDU either directly or indirectly was higher in all regions compared with the Northeast. The highest percentage increases were in the South. U.S. territories, and the North Central. From 1989 to 1990, the percentage of AIDS cases attributed directly to IDU increased in women and men (15.3 and 5.9%. respectively); however, the increase in sex partners of IDUs was much larger (34.5% in men and 29.196 in women). Increases were also higher in sex partners of IDUs than in IDUs when compared by race/ethnicity and by region of residence. Because HIV can spread rapidly among IDUs and their sex partners, there is an immediate need for targeting effective HIV prevention messages to all IDUs and their sex partners in communities with high HIV infection rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - HIV infections
KW - DRUGS of abuse
KW - INTRAVENOUS drug abusers
KW - COMMUNICABLE diseases
KW - UNITED States
N1 - Accession Number: 9409090164; Nwanyanwu, Okey C. 1 Chu, Susan Y. 1 Green, Timothy A. 1 Buehler, James W. 1 Berkelman, Ruth L. 1; Affiliation: 1: Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.; Source Info: 1993, Vol. 19 Issue 4, p399; Subject Term: AIDS (Disease); Subject Term: HIV infections; Subject Term: DRUGS of abuse; Subject Term: INTRAVENOUS drug abusers; Subject Term: COMMUNICABLE diseases; Subject Term: UNITED States; Number of Pages: 10p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Salmon, Marla E.
T1 - Editorial: Public Health Nursing--The Opportunity of a Century.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1993/12//
VL - 83
IS - 12
M3 - Editorial
SP - 1674
EP - 1675
PB - American Public Health Association
SN - 00900036
AB - The article discusses the importance of public health nursing in the U.S. In recent years, responsiveness has led public health nurses to take a more clinical, illness-oriented role rather than the traditional home and community-based preventive role. For more than 20 years health departments everywhere have been enticed into providing direct clinical care to people in their homes and clinics. Both public need and the revenue attached to these services have been the driving forces behind these changes. Public health nurses have been the human resource that has made these services a reality. These new assignments have diverted public health nurses from their major roles in assessment, surveillance, policy and health promotion and disease and injury prevention activities.
KW - PUBLIC health nursing
KW - PUBLIC health nurses
KW - NURSES
KW - MEDICAL care
KW - COMMUNITY health nursing
KW - UNITED States
N1 - Accession Number: 9405270125; Salmon, Marla E. 1; Affiliation: 1: Division of Nursing, Bureau of Health Professions, Health Resources and Services Administration, US Public Health Service; Source Info: Dec1993, Vol. 83 Issue 12, p1674; Subject Term: PUBLIC health nursing; Subject Term: PUBLIC health nurses; Subject Term: NURSES; Subject Term: MEDICAL care; Subject Term: COMMUNITY health nursing; Subject Term: UNITED States; NAICS/Industry Codes: 621610 Home Health Care Services; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wells, Barbara L.
AU - Brown, Charles C.
AU - Horm, John W.
AU - Carleton, Richard A.
AU - Lasater, Thomas M.
T1 - Who Participates in Cardiovascular Disease Risk Factor Screenings? Experience with a Religious Organized-Based Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/01//
VL - 84
IS - 1
M3 - Article
SP - 113
EP - 115
PB - American Public Health Association
SN - 00900036
AB - Adult members who declined participation in cardiovascular disease risk factor screenings offered at religious organizations were randomly selected and asked to participate in screenings at their homes. Relationships between screening participation and sociodemographic, behavioral, and physiological measures were examined. Age, knowledge of cardiovascular disease risk factors, body mass index, current smoking status, previous report of elevated blood pressure, current diastolic blood pressure measurement, frequency of worship service attendance, and residential distance from the religious organization predictors of screening response. Those with cospicuous risk factors appeared less likely to initially respond to religious organization site screening invitations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR diseases
KW - RELIGIOUS institutions
KW - MEDICAL screening
KW - DISEASES -- Risk factors
KW - SOCIODEMOGRAPHIC factors
N1 - Accession Number: 9406092486; Wells, Barbara L. 1 Brown, Charles C. 2 Horm, John W. 3 Carleton, Richard A. 4,5 Lasater, Thomas M. 6,7; Affiliation: 1: Bureau of Primary Health Care, Health Resources and Services Administration, Rockville, Md. 2: Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Md. 3: Division of Health Interview Statistics, National Center for Health Statistics, Hyattsville, Md. 4: Division of Cardiology, Memorial Hospital of Rhode Island, Pawtucket 5: Department of Medicine, Brown University, Providence, RI 6: Division of Health Education, Memorial Hospital of Rhode Island 7: Department of Community Health, Brown University; Source Info: Jan1994, Vol. 84 Issue 1, p113; Subject Term: CARDIOVASCULAR diseases; Subject Term: RELIGIOUS institutions; Subject Term: MEDICAL screening; Subject Term: DISEASES -- Risk factors; Subject Term: SOCIODEMOGRAPHIC factors; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 813110 Religious Organizations; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emmett, E. A.
AU - Risby, T. H.
AU - Taylor, J.
AU - Chen, C. L.
AU - Jtang, L.
AU - Feinman, S. E.
T1 - Skin elicitation threshold of ethylbutyl thiourea and mercaptobenzothiazole with relative leaching from sensitizing products.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 1994/02//
VL - 30
IS - 2
M3 - Article
SP - 85
EP - 90
SN - 01051873
AB - We studied 3 contact sensitizers present in rubber products, ethylbutyl thiourea (EBT), 2-mercaptobenzothiazole (MRT) and 2,2-dithio-bis-benzothiazole (MBTS), to relate the amount of sensitizer eliciting allergic contact dermatitis to the quantity leaching from a product into various biological fluids: normal saline, human plasma and 3 synthetic sweat solutions of pH 5.5 to 7.5. To determine the amount of sensitizer remaining after leaching, Soxhlet extraction with acetonitrile was subsequently performed. High-performance liquid chromatography was used for chemical analysis. 12 MBT-sensitive patients were patch tested with serial dilutions of MBT and MBTS in petrolatum. A Latin Square design was used in statistical analysis of variance of the patch test results. Large amounts of thioureas leached from 2 rubber articles eliciting thiourea dermatitis, the literature suggesting that these would have been well above the elicitation threshold. Leaching of MBTS was relatively greater than MBT into most media, whereas MBT was a more potent elicitor than MBTS at equivalent concentrations. The lowest eliciting concentration of MBT in 1 subject was 0.01%. Such information should prove helpful to manufacturers in designed products that do not release allergens sufficiently to cause reactions in consumers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN diseases
KW - THIOUREA
KW - PETROLATUM
KW - DERMATITIS herpetiformis
KW - DERMATOLOGY
KW - ALLERGENS
N1 - Accession Number: 12110301; Emmett, E. A. 1 Risby, T. H. 1 Taylor, J. 2 Chen, C. L. 1,3 Jtang, L. 1,3 Feinman, S. E. 4; Affiliation: 1: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. 2: Cleveland Clinic, Cleveland, Ohio, USA. 3: Shanghai Medical University, Shanghai, PRC. 4: Food and Drug Administration. Washington DC 20204, USA.; Source Info: Feb94, Vol. 30 Issue 2, p85; Subject Term: SKIN diseases; Subject Term: THIOUREA; Subject Term: PETROLATUM; Subject Term: DERMATITIS herpetiformis; Subject Term: DERMATOLOGY; Subject Term: ALLERGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; NAICS/Industry Codes: 324190 Other petroleum and coal product manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/1600-0536.ep12110301
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Mendell, Mark J.
AU - Fine, Lawrence
T1 - Editorial: Building Ventilation and Symptoms -- Where Do We Go From Here?
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/03//
VL - 84
IS - 3
M3 - Editorial
SP - 346
EP - 348
PB - American Public Health Association
SN - 00900036
AB - The article comments on the study by Jouni J.K. Jaakkola, Pekka Tuomaala and Olli Seppanen on the health aspects of mechanical ventilation of buildings in the U.S. Ventilation refers to the movement of outdoor air into a building. Its important aspect is the volumetric rate of air per person brought into a building. Other studies have examined the relationship between occupant symptoms and air ventilation rates in buildings. It was found that there was no significant symptom differences between ventilation rates.
KW - VENTILATION
KW - BUILDINGS -- Environmental engineering
KW - AIR quality
KW - ENVIRONMENTAL engineering
KW - SANITARY engineering
KW - UNITED States
N1 - Accession Number: 9406150677; Mendell, Mark J. 1 Fine, Lawrence 1; Affiliation: 1: Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Mar1994, Vol. 84 Issue 3, p346; Subject Term: VENTILATION; Subject Term: BUILDINGS -- Environmental engineering; Subject Term: AIR quality; Subject Term: ENVIRONMENTAL engineering; Subject Term: SANITARY engineering; Subject Term: UNITED States; NAICS/Industry Codes: 334512 Automatic Environmental Control Manufacturing for Residential, Commercial, and Appliance Use; NAICS/Industry Codes: 562998 All Other Miscellaneous Waste Management Services; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kennedy, Richard
AU - Veazie, Mark
AU - Conway, George
AU - Amandus, Harlan
T1 - Fishing Deaths in Alaska Vary by Fishery.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/03//
VL - 84
IS - 3
M3 - Letter
SP - 496
EP - 496
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Occupational Injury Deaths in Alaska's Fishing Industry, 1980 Through 1988," by P. G. Schnitzer and D. D. Landen, which appeared in the 1993 issue.
KW - LETTERS to the editor
KW - WORK-related injuries
N1 - Accession Number: 20695243; Kennedy, Richard 1 Veazie, Mark Conway, George Amandus, Harlan; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 3601 C St, Suite 250, Anchorage, AL 99503-5929; Source Info: Mar1994, Vol. 84 Issue 3, p496; Subject Term: LETTERS to the editor; Subject Term: WORK-related injuries; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Castillo, Dawn N.
AU - Landen, Deborah D.
AU - Layne, Larry A.
T1 - Occupational Injury Deaths of 16- and 17-Year-Olds in the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/04//
VL - 84
IS - 4
M3 - Article
SP - 646
EP - 649
PB - American Public Health Association
SN - 00900036
AB - Data from the National Traumatic Occupational Fatalities surveillance system were used to analyze occupational injury deaths of civilian 16- and 17-year-olds during 1980 through 1989. There were 670 deaths; the rate was 5.11 per 100,000 full-time equivalent workers. The leading causes of death were incidents involving motor vehicles and machines, electrocution, and homicide. Workers 16 and 17 years old appear to be at greater risk than adults for occupational death by electrocution, suffocation, drowning, poisoning, and natural and environmental factors. Improved enforcement of and compliance with federal child labor laws, evaluation of the appropriateness of currently permitted activities, and education are encouraged. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - CHILD labor -- Law & legislation
KW - YOUNG workers
KW - INDUSTRIAL safety
KW - OCCUPATIONAL mortality
N1 - Accession Number: 9406010244; Castillo, Dawn N. 1 Landen, Deborah D. 1 Layne, Larry A. 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV; Source Info: Apr94, Vol. 84 Issue 4, p646; Subject Term: WORK-related injuries; Subject Term: CHILD labor -- Law & legislation; Subject Term: YOUNG workers; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL mortality; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Layne, Larry A.
AU - Castillo, Dawn N.
AU - Stout, Nancy
AU - Cutlip, Patricia
T1 - Adolescent Occupational Injuries Requiring Hospital Emergency Department Treatment: A Nationally Representative Sample.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/04//
VL - 84
IS - 4
M3 - Article
SP - 657
EP - 660
PB - American Public Health Association
SN - 00900036
AB - Data from a nationally representative sample of emergency departments for the 6-month period July through December 1992 were used to examine nonfatal occupational injuries sustained by adolescents aged 14 through 17 years. There were 679 occupational injuries, corresponding to an estimated 37,405 injuries nationwide. Males constituted 65.8% of the injury victims. The injury rate for males was 7.0 per 100 full-time employees, compared with 4.4 for females. Lacerations to the hand or finger accounted for 25.6% of all injuries. The majority of injuries occurred in retail trades (53.7%), which also had the highest rate (6.3 per 100 full-time employees). Seventy-one percent of the injuries in retail trade occurred in eating and drinking establishments. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - TEENAGERS -- Wounds & injuries
KW - HOSPITAL emergency services
KW - INDUSTRIAL safety
KW - RETAIL industry
N1 - Accession Number: 9406010247; Layne, Larry A. 1 Castillo, Dawn N. 1 Stout, Nancy 1 Cutlip, Patricia 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WVa.; Source Info: Apr94, Vol. 84 Issue 4, p657; Subject Term: WORK-related injuries; Subject Term: TEENAGERS -- Wounds & injuries; Subject Term: HOSPITAL emergency services; Subject Term: INDUSTRIAL safety; Subject Term: RETAIL industry; NAICS/Industry Codes: 452999 All other miscellaneous general merchandise stores; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Jenkins, Barbara
AU - Ames, Richard G.
AU - O'Malley, Michael
AU - Chrislip, David
AU - Russo, John
T1 - Chronic Neurological Sequelae to Organophosphate Pesticide Poisoning.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/05//
VL - 84
IS - 5
M3 - Article
SP - 731
EP - 736
PB - American Public Health Association
SN - 00900036
AB - Objectives. This work was undertaken to determine whether there are any chronic neurological sequelae to acute organophosphate pesticide poisoning. Methods. California surveillance data were used in a study of neurological function among 128 men poisoned by organophosphate pesticides in California from 1982 to 1990 and 90 referents. Tests included a neurological physical examination, 5 nerve conduction tests, 2 vibrotactile sensitivity tests, 10 neurobehavioral tests, and 1 postural sway test. Results. After correcting for confounding, the poisoned group performed significantly worse than the referent group on two neurobehavioral tests (sustained visual attention and mood scales). When the data were restricted to men with documented cholinesterase inhibition (n = 83) or to men who had been hospitalized (n = 36), the poisoned subjects also showed significantly worse vibrotactile sensitivity of finger and toe. Significant trends of increased impairment were found with increased days of disability on a wide spectrum of tests of both central and peripheral nerve function. Conclusions. While these findings are limited by low response rates and by small sample sizes for specific pesticides, this study was based on a large surveillance database and is the largest study to date of the chronic effects of organophosphate pesticide poisoning. The evidence of some long-term effects of poisoning is consistent with two prior studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANOPHOSPHORUS compounds
KW - PESTICIDES -- Toxicology
KW - PUBLIC health surveillance
KW - SPRAYING
KW - POISONS
KW - CALIFORNIA
N1 - Accession Number: 9406223444; Steenland, Kyle 1 Jenkins, Barbara 1 Ames, Richard G. 2 O'Malley, Michael 2 Chrislip, David 1 Russo, John 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: California Environmental Protection Agency in Berkeley and Sacramento; Source Info: May94, Vol. 84 Issue 5, p731; Subject Term: ORGANOPHOSPHORUS compounds; Subject Term: PESTICIDES -- Toxicology; Subject Term: PUBLIC health surveillance; Subject Term: SPRAYING; Subject Term: POISONS; Subject Term: CALIFORNIA; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garrett, J. T.
AU - Garrett, Michael Walking
T1 - The Path of Good Medicine: Understanding and Counseling Native American Indians.
JO - Journal of Multicultural Counseling & Development
JF - Journal of Multicultural Counseling & Development
Y1 - 1994/07//
VL - 22
IS - 3
M3 - Article
SP - 134
EP - 144
PB - Wiley-Blackwell
SN - 08838534
AB - The article discusses the cultural values, beliefs, and practices of native American Indians. While walking in the Smoky Mountains one brisk fall day, an elder medicine man came upon a young Indian man sitting on the ground. He asked the young man why he was sitting there like that, sensing that the young man was troubled by something. The young man replied that he was sitting there because he did not know which way to go. The article author believes that one should not separate the person from the spirituality or from affiliation with the tribal group. These aspects may very well be central to how Native American Indian clients view themselves and define their world. They honor this sacred relationship by being open and respectful. It is always important to recognize the relative nature of value judgments such as right or wrong and good or bad. If counselors come first as students, and second, as professionals, they might be surprised at how much growth would take place by members of both worlds. Native American Indians view the respected person as one who acts in the most friendly, generous, considerate, and modest way.
KW - NATIVE Americans -- Social life & customs
KW - CULTURAL values
KW - FAITH
KW - HONOR
KW - VALUES (Ethics)
KW - COUNSELING
N1 - Accession Number: 9502164887; Garrett, J. T. 1 Garrett, Michael Walking; Affiliation: 1: Division director of the Health Care Administration/Contract Health O Services. USPHS, Indian Health Service.; Source Info: Jul94, Vol. 22 Issue 3, p134; Subject Term: NATIVE Americans -- Social life & customs; Subject Term: CULTURAL values; Subject Term: FAITH; Subject Term: HONOR; Subject Term: VALUES (Ethics); Subject Term: COUNSELING; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 4090
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Scribner, Curtis L.
AU - Kapit, Richard M.
AU - Phillips, Evelyne T.
AU - Rickles, Nathaniel M.
T1 - Aseptic Meningitis and Intravenous Immunoglobulin Therapy .
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 1994/08/15/
VL - 121
IS - 4
M3 - Editorial
SP - 305
EP - 306
SN - 00034819
AB - Editorial. Deals with the association of aseptic meningitis syndrome with the use of intravenous immunoglobulin. Side effects reported with infusions of intravenous immunoglobulin; Information on U.S. Food and Drug Administration MEDWatch system; Indication for administration of intravenous immunoglobulin in the cases reported to MEDWatch.
KW - MENINGITIS
KW - IMMUNOGLOBULINS
N1 - Accession Number: 6977749; Scribner, Curtis L. 1 Kapit, Richard M. 1 Phillips, Evelyne T. 1 Rickles, Nathaniel M. 1; Affiliation: 1: Food and Drug Administration, Rockville; Source Info: 8/15/94, Vol. 121 Issue 4, p305; Subject Term: MENINGITIS; Subject Term: IMMUNOGLOBULINS; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 1439
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Birthweight Differentials among Asian Americans.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/09//
VL - 84
IS - 9
M3 - Article
SP - 1444
EP - 1449
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examines differentials in mean birthweight and the risk for low birthweight among various Asian-American groups in New York State (n = 499 377). Methods. Using resident singleton live-birth records from New York State for 1985 and 1986, Asian-American births were compared with Black, American Indian, and White births. Multivariate ordinary least squares and logistic regression models were used to analyze ethnic differences. Results. Compared with White births, the expected mean difference in birthweight was -115 g for Chinese, -235 g for Japanese, -164 g for Filipinos, -120 g for Blacks, and 74 g for American Indians. The risk for low birthweight was 45% higher for Filipinos and 49% higher for Blacks as compared with Whites. Conclusions. Results of this study suggest substantial heterogeneity in mean birthweight and risk for low birthweight among ethnic groups in general and the major Asian-American groups in particular. Interestingly, after controlling for ethnic differences in sociodemographic risk factors, Filipinos appear to resemble Blacks much more closely than they do their Japanese and Chinese counterparts with respect to risk for low birthweight. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIRTH weight
KW - ASIAN Americans
KW - LEAST squares
KW - LOGISTIC regression analysis
KW - FILIPINOS
KW - NATIVE Americans
KW - UNITED States
N1 - Accession Number: 9410250729; Singh, Gopal K. 1 Yu, Stella M. 2; Affiliation: 1: National Center for Health Statistics, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; Source Info: Sep94, Vol. 84 Issue 9, p1444; Subject Term: BIRTH weight; Subject Term: ASIAN Americans; Subject Term: LEAST squares; Subject Term: LOGISTIC regression analysis; Subject Term: FILIPINOS; Subject Term: NATIVE Americans; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Behrens, Virginia
AU - Seligman, Paul
AU - Cameron, Lorraine
AU - Mathias, C. G. Toby
AU - Fine, Lawrence
T1 - The Prevalence of Back Pain, Hand Discomfort, and Dermatitis in the US Working Population.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1780
EP - 1780
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of the study was to provide the health care and public health communities with national prevalence estimates of selected conditions in the US working population. Methods. National prevalence estimates of self-reported conditions among working people were calculated from data collected for the 1988 Occupational Health Supplement to the National Health Interview Survey. Results. The highest prevalence estimates were found among occupational groups. For example, the prevalence of back pain due to an injury at work among truck drivers was 6.7%: back pain due to repeated activities at work among mechanics and repairers of heavy equipment and machinery was 10.5%; hand discomfort among operators of machines that process metal, plastic, stone, and glass was 23.5%; and dermatitis due to contact with substances at work among physicians, dentists, nurses, pharmacists, and dietitians was 5.6%. Conclusions. A substantial proportion of these conditions among occupational groups with the highest prevalence estimates are occupational in origin. These prevalence estimates identify occupations in which efforts are needed to prevent these conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - BACKACHE
KW - SKIN -- Inflammation
KW - HEALTH surveys
KW - PUBLIC health
N1 - Accession Number: 9411285523; Behrens, Virginia 1 Seligman, Paul 1 Cameron, Lorraine 1 Mathias, C. G. Toby 2 Fine, Lawrence 1; Affiliation: 1: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: Group Health Associates, Cincinnati, Ohio; Source Info: Nov94, Vol. 84 Issue 11, p1780; Subject Term: INDUSTRIAL hygiene; Subject Term: BACKACHE; Subject Term: SKIN -- Inflammation; Subject Term: HEALTH surveys; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Serdula, Mary K.
AU - Williamson, David F.
AU - Anda, Robert F.
AU - Levy, Alan
AU - Heaton, Alan
AU - Byers, Tim
T1 - Weight Control Practices in Adults: Result of a Multistate Telephone Survey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1821
EP - 1821
PB - American Public Health Association
SN - 00900036
AB - In this study, data collected in 1989 in a random-digit dialing telephone survey of 60 590 adults in 38 states and the District of Columbia were analyzed. Approximately 38% of women and 24% of men reported that they were currently trying to lose weight. Methods reported were counting calories (24% of women, 14% of Men), participating in organized weight loss programs (10%, 3%), taking special supplements (10%, 7%), taking diet pills (4%, 2%), and fasting for 24 hours or longer (5%, 5%). Among both sexes, only half of those trying to lose weight reported using the recommended method of caloric restriction combined with physical activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEIGHT loss
KW - LOW-calorie diet
KW - DIETARY supplements
KW - APPETITE depressants
KW - FASTING
KW - TELEPHONE surveys
N1 - Accession Number: 9411285531; Serdula, Mary K. 1 Williamson, David F. 1 Anda, Robert F. 1 Levy, Alan 2 Heaton, Alan 2 Byers, Tim 1; Affiliation: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Division of Consumer Studies, Food and Drug Administration, Washington, DC; Source Info: Nov94, Vol. 84 Issue 11, p1821; Subject Term: WEIGHT loss; Subject Term: LOW-calorie diet; Subject Term: DIETARY supplements; Subject Term: APPETITE depressants; Subject Term: FASTING; Subject Term: TELEPHONE surveys; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stuart, Charles A.
AU - Smith, Michele M.
AU - Gilkison, Charles R.
AU - Shaheb, Sudah
AU - Stahn, Ruggles M.
T1 - Acanthosis Nigricans among Native Americans: An Indicator of High Diabetes Risk.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1994/11//
VL - 84
IS - 11
M3 - Article
SP - 1839
EP - 1839
PB - American Public Health Association
SN - 00900036
AB - Prevalence of the skin lesion acanthosis nigricans was determined in two tribal communities in Texas and Nebraska. Thirty-eight percent of the Alabama-Coushatta tribe of Texas had acanthosis nigricans. Nineteen percent of Omaha and Winnebago tribal children had the skin lesion, the youngest children had the least acanthosis nigricans. Among weight-matched Albama-Coushatta, fasting insulin concentration were twofold higher in subjects with the lesion. It was concluded that acanthosis nigricans is highly prevalent among Native Americans and that its presence suggests insulin resistance. Thus, it may identify those with the highest risk for non-insulin-dependent diabetes mellitus in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACANTHOSIS nigricans
KW - SKIN diseases
KW - INSULIN resistance
KW - DIABETES
KW - TRIBES
KW - TEXAS
KW - NEBRASKA
N1 - Accession Number: 9411285537; Stuart, Charles A. 1 Smith, Michele M. 2 Gilkison, Charles R. 1 Shaheb, Sudah 2 Stahn, Ruggles M.; Affiliation: 1: Department of Internal Medicine, University of Texas Medical Branch, Galveston 2: Public Health Service Indian Health Service Hospital, Winnebago, Neb.; Source Info: Nov94, Vol. 84 Issue 11, p1839; Subject Term: ACANTHOSIS nigricans; Subject Term: SKIN diseases; Subject Term: INSULIN resistance; Subject Term: DIABETES; Subject Term: TRIBES; Subject Term: TEXAS; Subject Term: NEBRASKA; Number of Pages: 4p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morrow-Howell, Nancy
T1 - The M word: Multicollinearity in multiple regression.
JO - Social Work Research
JF - Social Work Research
Y1 - 1994/12//
VL - 18
IS - 4
M3 - Article
SP - 247
EP - 251
PB - Oxford University Press / USA
SN - 10705309
AB - The article focuses on ways to deal with multicollinearity in multiple regression. Multicollinearity concerns only the relationships of the independent variables. Independent variables are highly correlated when information is redundant. although there may be a good reason for a researcher to collect redundant information, redundancy is not desirable in multiple regression. hen a correlation between independent variables is one, and there is perfect collinearity, the parameter cannot be calculated; perfect collinearity makes the necessary calculations mathematically impossible. Researchers could make this mistake if a categorical variable is converted to a series of dummy variables for inclusion in a regression model and all categories are retained in the model, or if a total score is computed from several subscores and the total and subscores are included in the same model. Large correlations do not prevent the inversion of the matrix, but the regression coefficients produced have two problems: inflated standard errors on the parameter estimates and reduced magnitude of the parameter estimates. It is always best to reduce the number of independent variables for conceptual reasons before multicollinearity problems arise in the calculations of the model estimates. The simplest solution is to omit the offending variable if only one correlation is the problem, which may be desirable if the researcher finds appeal in a simpler model. Another solution is to combine information from two variables into one. Rescaling the data has been suggested as a way to reduce multicollinearity. Especially in polynomial regression models, centering the original data can relieve multicollinearity problems. Two alternative solutions allow for retaining all the independent variables as they are. One approach is not to interpret the individual parameters at all but only use the model information, the R². Another solution is to use regression techniques other than least squares.
KW - MULTIPLE regression analysis
KW - REGRESSION analysis
KW - SOCIAL work research
KW - MATHEMATICAL statistics
KW - MATHEMATICAL models
N1 - Accession Number: 9607260352; Morrow-Howell, Nancy 1; Affiliation: 1: Associate Professor and Investigator, Center for Mental Health Services George Warren Brown School of Social Work, Washington University, Campus Box 1196, St. Louis, MO 63130; Source Info: Dec94, Vol. 18 Issue 4, p247; Subject Term: MULTIPLE regression analysis; Subject Term: REGRESSION analysis; Subject Term: SOCIAL work research; Subject Term: MATHEMATICAL statistics; Subject Term: MATHEMATICAL models; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3544
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dzanis, David A.
T1 - The Association of American Feed Control Officials Dog and Cat Food Nutrient Profiles: Substantiation of Nutritional Adequacy of Complete and Balanced Pet Foods in the United.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1994/12/02/Dec94 Supplement
VL - 124
M3 - Article
SP - 2535S
EP - 2539S
SN - 00223166
AB - The Association of American Feed Control Official (AAFCO) formed the Canine (1990–1991) and Feline (1991–1992) Nutrition Expert Subcommittees to update the requirements for substantiation of ‘complete and balanced’ claims for pet foods sold in the United States. There are two means by which a company may substantiate nutritional adequacy for a dog or cat food. The first means is by formulating the food so that nutrient levels fall within the ranges as established in the AAFCO Dog and Cat Food Nutrient Profiles. These profiles replace the National Research Council recommendations as the recognized authority in the United States as that term is applied to AAFCO regulations. Levels of nutrients are based on practical formulations of pet foods with adjustments to account for bioavailability of nutrients in commonly used ingredients. Separate profiles for adult maintenance and growth and reproduction are set, and maximum levels of some nutrients are also established. The second means of substantiation is through the conduct of feeding trials following AAFCO protocols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PETS -- Feeding & feeds
KW - ANIMAL nutrition
KW - BIOAVAILABILITY
KW - FOOD of animal origin
KW - DOGS -- Food
KW - CATS -- Food
KW - NUTRITION research
KW - UNITED States
KW - cats
KW - dogs
KW - nutrient profiles
KW - nutritional requirements
KW - symposium
KW - ASSOCIATION of American Feed Control Officials
N1 - Accession Number: 22583758; Dzanis, David A. 1; Affiliation: 1: Division of Animal Feeds, Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD 20855; Source Info: Dec94 Supplement, Vol. 124, p2535S; Subject Term: PETS -- Feeding & feeds; Subject Term: ANIMAL nutrition; Subject Term: BIOAVAILABILITY; Subject Term: FOOD of animal origin; Subject Term: DOGS -- Food; Subject Term: CATS -- Food; Subject Term: NUTRITION research; Subject Term: UNITED States; Author-Supplied Keyword: cats; Author-Supplied Keyword: dogs; Author-Supplied Keyword: nutrient profiles; Author-Supplied Keyword: nutritional requirements; Author-Supplied Keyword: symposium; Company/Entity: ASSOCIATION of American Feed Control Officials; NAICS/Industry Codes: 311111 Dog and Cat Food Manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 453910 Pet and Pet Supplies Stores; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Ingster, Lillian M.
AU - Cartwright, William S.
T1 - Drug Disorders and Cardiovascular Disease: The Impact on Annual Hospital Length of Stay for the Medicare Population.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1995/02//
VL - 21
IS - 1
M3 - Article
SP - 93
EP - 110
SN - 00952990
AB - We studied 3,942,868 Medicare patients (comprised of elderly and disabled) discharged with cardiovascular disease (CVD) during 1987, of which 41,095 (1%) had a drug disorder. Among this small subgroup, the percent of those overlapping with an alcohol and/or mental disorder is 33% for the elderly and 47% for the disabled. The presence of a drug disorder discharge diagnosis is associated with an excess of 329,650 days of hospital care and $174,498,071 in hospital charges as illustrated by a 51% increase in average annual days in the hospital for the elderly, and a similar 61% increase for the disabled. The concomitant increase in average annual discharges offers an explanation. Clinical progression in drug disorder severity (six categories were defined) is associated with increasing lengths of stay; for example, drug dependence comorbidities present longer lengths of stay than drug abuse comorbidities. Among the 12 categories of CVD defined, patients with rheumatic heart disease, hypertensive heart disease, hypertension, and other venous disorders were chose whose length of stay experienced the largest percent increase when a drug disorder was present. When drug disorders compete with alcohol and/or mental disorders in a general linear model predicting average annual length of stay, they remain significant at the p < .001 level. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR diseases
KW - LENGTH of stay in hospitals
KW - MEDICARE
KW - CARDIOVASCULAR system
KW - HEALTH insurance
KW - UNITED States
N1 - Accession Number: 9505022970; Ingster, Lillian M. 1 Cartwright, William S. 2; Affiliation: 1: National Center for Health Statistics 6525 Belcrest Hd., Hyattsville, Maryland 20782. 2: Information Services & Analysis Branch Division of State Programs Center for Substance Abuse Treatment 5600 Fishers Lane-Rockwall II Bfdg., Rockville, Maryland.; Source Info: Feb95, Vol. 21 Issue 1, p93; Subject Term: CARDIOVASCULAR diseases; Subject Term: LENGTH of stay in hospitals; Subject Term: MEDICARE; Subject Term: CARDIOVASCULAR system; Subject Term: HEALTH insurance; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 18p; Illustrations: 5 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murthy, Leela I.
AU - Halperin, William E.
T1 - Medical Screening and Biological Monitoring.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/02//
VL - 37
IS - 2
M3 - Article
SP - 170
EP - 184
SN - 00961736
AB - The use of medical screening and biological monitoring has seen substantial changes in the past two decades specifically in the provision of occupational medical services. For example, national surveys of workplaces conducted by the National Institute for Occupational Safety and Health (NIOSH) showed that the provision of off-site medical care to workers increased from 19.6% in 1972-1974 to 57.8% in 1981- 1983, although the percent of workers receiving on-site services remained stable during the same period. After a recent survey in 1990—1991, the Occupational Safety and Health Administration (OSHA) estimated that 6.3% of US industries have a medical surveillance program at their individual establishment. We reviewed NIOSH documents, OSHA's Code of Federal Regulations, and texts on biological monitoring and medical screening for recommendations on medical surveillance of workers. This report summarizes the medical tests (including biologic monitoring) recommended or used by independent investigators and by the government for OSHA-regulated substances to provide guidance to physicians and occupational health professionals in accessing the pertinent literature; the utility of the recommendations is not evaluated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113380016; Murthy, Leela I. 1 Halperin, William E. 1; Affiliation: 1: 1 Chemist, From the National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 2 Associate Director for Surveillance, From the National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 3 Dr.Murthy is Currently at the Division of Standards Development and Technology Transfer, NIOSH; Source Info: Feb1995, Vol. 37 Issue 2, p170; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rivo, Marc L.
AU - Henderson, Tim M.
AU - Jackson, Debbie M.
T1 - State Legislative Strategies to Improve the Supply and Distribution of Generalist Physicians, 1985 to 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/03//
VL - 85
IS - 3
M3 - Article
SP - 405
EP - 407
PB - American Public Health Association
SN - 00900036
AB - State laws enacted between 1985 and 1992 were reviewed to examine state involvement in influencing the supply and distribution of generalist physicians. Forty-seven states enacted 238 relevant laws during this period. In 1991 and 1992, 36 states enacted 98 laws, as compared with 1985 and 1986, when 8 states enacted 12 laws. Legislation addressed planning and oversight; financial incentives to institutions, students, and residents; and strategies to enhance the practice environment. A new strategy is to link funding to measurable outcomes, such as the career choices of a state medical school's graduates. Few states devoted resources to evaluate their efforts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATE laws
KW - PHYSICIANS
KW - LABOR supply
KW - LABOR laws & legislation
KW - MEDICAL laws & legislation
KW - INCENTIVES in industry
N1 - Accession Number: 9504040213; Rivo, Marc L. 1 Henderson, Tim M. 2 Jackson, Debbie M. 1; Affiliation: 1: Division of Medicine, Bureau of Health Professions, Health Resources and Services Administration, Rockville, Md. 2: Intergovernmental Health Policy Project, George Washington University, Washington, DC.; Source Info: Mar1995, Vol. 85 Issue 3, p405; Subject Term: STATE laws; Subject Term: PHYSICIANS; Subject Term: LABOR supply; Subject Term: LABOR laws & legislation; Subject Term: MEDICAL laws & legislation; Subject Term: INCENTIVES in industry; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yetley, Elizabeth A.
AU - Park, Youngmee K.
T1 - Diet and Heart Disease: Health Claims.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1995/03/02/Mar95 Supplement
VL - 125
M3 - Article
SP - 679S
EP - 685S
SN - 00223166
AB - The Nutrition Labeling and Education Act of 1990 states, in part, that a product is misbranded if it bears a claim that characterizes the relationship of a nutrient to a disease or health-related condition (health claim), unless the claim is made in accordance with Food and Drug Administration (FDA) regulations. In response to the new law, on January 6, 1993, the FDA promulgated regulations that described general requirements for health claims on foods in conventional food forms and specific requirements for seven authorized health claim topics. Three authorized claims are related to heart disease: dietary saturated fat and cholesterol and coronary heart disease; fruits, vegetables and grain products that contain fiber, particularly soluble fiber, and risk of coronary heart disease and sodium and hypertension. The general requirements regulation specifies the scientific standard for assessing the validity of claims, criteria for the qualification of claims, conditions for disqualification and general labeling requirements for health claims. Approval for health claims is based on the totality of publicly available scientific evidence and significant agreement among experts qualified by scientific training and experience to evaluate the relationship. On January 4, 1994, the FDA finalized similar requirements for health claims on dietary supplements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIET therapy
KW - ELEMENTAL diet
KW - DIET in disease
KW - CORONARY heart disease
KW - HEART diseases
KW - HYPERTENSION
KW - SODIUM -- Physiological effect
KW - BLOOD lipids
KW - LIPID metabolism disorders
KW - FOOD -- Fiber content
KW - FIBER in human nutrition
KW - diet and health
KW - fiber-rich foods and coronary heart disease
KW - health claim
KW - lipids and coronary heart disease
KW - sodium and hypertension
N1 - Accession Number: 22569260; Yetley, Elizabeth A. 1 Park, Youngmee K. 1; Affiliation: 1: Food and Drug Administration, U.S. Department of Health and Human Services, Washington, DC 20204; Source Info: Mar95 Supplement, Vol. 125, p679S; Subject Term: DIET therapy; Subject Term: ELEMENTAL diet; Subject Term: DIET in disease; Subject Term: CORONARY heart disease; Subject Term: HEART diseases; Subject Term: HYPERTENSION; Subject Term: SODIUM -- Physiological effect; Subject Term: BLOOD lipids; Subject Term: LIPID metabolism disorders; Subject Term: FOOD -- Fiber content; Subject Term: FIBER in human nutrition; Author-Supplied Keyword: diet and health; Author-Supplied Keyword: fiber-rich foods and coronary heart disease; Author-Supplied Keyword: health claim; Author-Supplied Keyword: lipids and coronary heart disease; Author-Supplied Keyword: sodium and hypertension; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lee, Philip R.
AU - Stewart, Felicia H.
T1 - Editorial: Failing to Prevent Unintended Pregnancy Is Costly.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Editorial
SP - 479
EP - 480
PB - American Public Health Association
SN - 00900036
AB - The article discusses issues concerning the failure to prevent unintended pregnancy. In the U.S., more than half of all pregnancies are unintended. It addresses the significance of contraception in the prevention of unwanted pregnancy. Moreover, some of the cost-effective contraceptives mentioned include oral, injectable, and implanted hormonal contraceptives and intrauterine devices. Another way to prevent pregnancy is the utilization of emergency contraceptive pill treatment after unprotected intercourse.
KW - UNWANTED pregnancy
KW - CONTRACEPTIVES
KW - ORAL contraceptives
KW - INTRAUTERINE contraceptives
KW - COST effectiveness
KW - SEXUAL intercourse
KW - UNITED States
N1 - Accession Number: 20700159; Lee, Philip R. 1 Stewart, Felicia H. 2; Affiliation: 1: Public Health Service, US Department of Health and Human Services, Washington, DC. 2: Office of Population Affairs, Public Health Service, US Department of Health and Human Services, Bethesda, Md.; Source Info: Apr95, Vol. 85 Issue 4, p479; Subject Term: UNWANTED pregnancy; Subject Term: CONTRACEPTIVES; Subject Term: ORAL contraceptives; Subject Term: INTRAUTERINE contraceptives; Subject Term: COST effectiveness; Subject Term: SEXUAL intercourse; Subject Term: UNITED States; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2p; Document Type: Editorial
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DB - aph
ER -
TY - JOUR
AU - Trussel, James
AU - Leveque, Joseph A.
AU - Koenig, Jacqueline D.
AU - London, Robert
AU - Borden, Spencer
AU - Henneberry, Joan
AU - LaGuardia, Katherine
AU - Stewart, Felicia
AU - Wilson, T. George
AU - Wysocki, Susan
AU - Strauss, Michael
T1 - The Economic Value of Contraception: A Comparison of 15 Methods.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Article
SP - 494
EP - 503
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of the study was to determine the clinical and economic impact of alternative contraceptive methods. Methods. Direct medical costs (method use, side effects, and unintended pregnancies) associated with 15 contraceptive methods were modeled from the perspectives of a private payer and a publicly funded program. Cost data were drawn from a national claims database and Medical. The main outcome measures included 1-year and 5-year costs and number of pregnancies avoided compared with use of no contraceptive method. Results. All 15 contraceptives were more effective and less costly than no method. Over 5 years, the copper-T IUD, vasectomy, the contraceptive implant, and the injectable contraceptive were the most cost-effective, saving $14 122, $13 899, $13 813, and $13 373, respectively, and preventing approximately the same number of pregnancies (4.2) per person. Because of their high failure rates, barrier methods, spermieides, withdrawal, and periodic abstinence were costly but still saved from $8933 to $12 239 over 5 years. Oral contraceptives fell between these groups, costing $1784 over 5 years, saving $12 879, and preventing 4.1 pregnancies. Conclusions. Contraceptives save health care resources by preventing unintended pregnancies. Up-front acquisition costs are inaccurate predictors of the total economic costs of competing contraceptive methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTRACEPTIVES
KW - MEDICAL care costs
KW - DATABASES
KW - PREGNANCY
KW - VASECTOMY
KW - INJECTABLE contraceptives
N1 - Accession Number: 9504260426; Trussel, James 1,2; Email Address: trussel@princeton.edu Leveque, Joseph A. 3 Koenig, Jacqueline D. 3 London, Robert 4 Borden, Spencer 5 Henneberry, Joan 6 LaGuardia, Katherine 7 Stewart, Felicia 8 Wilson, T. George 9 Wysocki, Susan 10 Strauss, Michael 3; Affiliation: 1: Office of Population Research, Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ. 2: Department of Economics, Princeton University, Princeton, NJ. 3: Health Technology Associates, Washington, DC. 4: Department of Obsterics and Gynecology, Kaiser Permaente Medical Group, Mid-Atlantic Region, Baltimore, Md. 5: Wyatt Company, Wellesley, Mass. 6: Colorado Department of Health, Denver, Colo. 7: Department of Obstetrics and Gynecology, Cornell University Medical College, New York, NY. 8: Office of Population Affairs, US Department of Health and Human Services, Bethesda, Md. 9: California Department of Health Services, Sacramento, California 10: National Association of Nurse Practitioners in Reproductive Health, Washington, DC.; Source Info: Apr95, Vol. 85 Issue 4, p494; Subject Term: CONTRACEPTIVES; Subject Term: MEDICAL care costs; Subject Term: DATABASES; Subject Term: PREGNANCY; Subject Term: VASECTOMY; Subject Term: INJECTABLE contraceptives; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 10p; Illustrations: 6 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roscoe, Robert J.
AU - Deddens, James A.
AU - Salvan, Alberto
AU - Schnorr, Teresa M.
T1 - Mortality among Navajo Uranium Miners.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/04//
VL - 85
IS - 4
M3 - Article
SP - 535
EP - 540
PB - American Public Health Association
SN - 00900036
AB - Objectives. To update mortality risks for Navajo uranium miners, a retrospective cohort mortality study was conducted of 757 Navajos from the cohort of Colorado Plateau uranium miners. Methods. Vital status was followed from 1960 to 1990. Standardized mortality ratios were estimated, with combined New Mexico and Arizona non-white mortality rates used for comparison. Cox regression models were used to evaluate exposure-response relationships. Results. Elevated standardized mortality ratios were found for lung cancer (3.3), tuberculosis (2.6), and pneumoconioses and other respiratory diseases (2.6). Lowered ratios were found for heart disease (0.6), circulatory disease (0.4), and liver cirrhosis (0.5). The estimated relative risk for a 5-year duration of exposure vs none was 3.7 for lung cancer, 2.1 for pneumoconiosis and other respiratory diseases, and 2.0 for tuberculosis. The relative risk for lung cancer was 6.9 for the midrange of cumulative exposure to radon progeny compared with the least exposed. Conclusions. Findings were consistent with those from previous studies. Twenty-three years after their last exposure to radon progeny, these light-smoking Navajo miners continue to face excess mortality risks from lung cancer and pneumoconioawa and other respiratory diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - URANIUM miners
KW - NAVAJO (North American people)
KW - LUNGS -- Cancer
KW - TUBERCULOSIS
KW - COLORADO Plateau
N1 - Accession Number: 9504260432; Roscoe, Robert J. 1 Deddens, James A. 1,2 Salvan, Alberto 1,3 Schnorr, Teresa M. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: Department of Mathematical Sciences, University of Cincinnati 3: LADSEB, National Research Council, Padova, Italy; Source Info: Apr95, Vol. 85 Issue 4, p535; Subject Term: MORTALITY; Subject Term: URANIUM miners; Subject Term: NAVAJO (North American people); Subject Term: LUNGS -- Cancer; Subject Term: TUBERCULOSIS; Subject Term: COLORADO Plateau; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crane, Nancy T.
AU - Wilson, Dennis B.
AU - Lewis, Christine J.
AU - Cook, D. Annetta
AU - Rader, Jeanne I.
AU - Yetley, Elizabeth A.
T1 - Evaluating Food Fortification Options: General Principles Revisited with Folic Acid.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/05//
VL - 85
IS - 5
M3 - Article
SP - 660
EP - 666
PB - American Public Health Association
SN - 00900036
AB - Objectives. This article uses folic acid as an example to illustrate some of the complex issues and general principles that emerge when evaluating fortification of the food supply as one possible means to address a public health recommendation. Methods. Distributions of current daily folate intakes from conventional foods and dietary supplements were estimated. Intakes that might result from fortification of cereal-grain products and ready-to-eat cereals at various levels for eight age-gender groups were also estimated by using the US Department of Agriculture's 1987-1988 Nationwide Food Consumption Survey. Results. The results illustrate that fortification of the US food supply tends to increase folate intakes of consumers at the high end of the intake distribution curves in the target population. Conclusions. The effectiveness of food fortification options for a target population and the safety for the general population impose conflicting challenges that must be considered concurrently when making decisions about fortifying the US food supply. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - ENRICHED foods
KW - PUBLIC health
KW - CEREAL products
KW - FOOD supply
KW - UNITED States
N1 - Accession Number: 9505300899; Crane, Nancy T. 1 Wilson, Dennis B. 1 Lewis, Christine J. 1 Cook, D. Annetta 2 Rader, Jeanne I. 3 Yetley, Elizabeth A. 3; Affiliation: 1: Center for Food Safety and applied Nutrition, Food and Drug Administration, Washington, DC 2: Agricultural Research Services, US Department of Agriculture, Washington, DC 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC; Source Info: May95, Vol. 85 Issue 5, p660; Subject Term: FOLIC acid; Subject Term: ENRICHED foods; Subject Term: PUBLIC health; Subject Term: CEREAL products; Subject Term: FOOD supply; Subject Term: UNITED States; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biener, Lois
AU - Heaton, Alan
T1 - Women Dieters of Normal Weight: Their Motives, Goals, and Risks.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/05//
VL - 85
IS - 5
M3 - Article
SP - 714
EP - 717
PB - American Public Health Association
SN - 00900036
AB - Using data from a national survey of weight loss practices, this study examined those dieters who were of normal weight. Forty-Seven percent of White women, 25% of Black women, and 16% of men currently trying to lose weight had a body mass index under 25. Women's primary motive was health improvement. Among normal-weight female dieters, 12% of Whites and 27% of Blacks were using risky strategies. Dieters were less likely than nondieters to smoke and reported better nutritional practices; however, they were not more likely to exercise, and their maximum weight fluctuation was 50% greater. Additional research on the consequences of dieting among normal-weight individuals is of high priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REDUCING diets
KW - WOMEN -- Health
KW - MOTIVATION (Psychology)
KW - RACIAL differences
KW - BODY mass index
KW - RISK-taking (Psychology)
N1 - Accession Number: 9505300918; Biener, Lois 1 Heaton, Alan 2; Affiliation: 1: Center for Survey Research, University of Massachusetts, Boston 2: US Food and Drug Administration, Washington, DC; Source Info: May95, Vol. 85 Issue 5, p714; Subject Term: REDUCING diets; Subject Term: WOMEN -- Health; Subject Term: MOTIVATION (Psychology); Subject Term: RACIAL differences; Subject Term: BODY mass index; Subject Term: RISK-taking (Psychology); Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Ordin, Diana L.
AU - Fine, Lawrence J.
T1 - Editorial: Surveillance for Pesticide-Related Illness--Lessons From California.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/06//
VL - 85
IS - 6
M3 - Editorial
SP - 762
EP - 763
PB - American Public Health Association
SN - 00900036
AB - This article reflects on the effectiveness of the surveillance system for pesticide-related illnesses in California. Like its overall approach to pesticide regulation, the worker safety program in the California Department of Pesticide Regulation is the most stringent in the U.S. The surveillance system in California offers routine information crucial for prevention. An estimate of the magnitude of the problem of pesticide-related illness is being offered by the system, it also identifies clusters and previously unrecognized problems, elucidates risk factors and identifies high-risk workers, workplaces and work practices.
KW - PUBLIC health surveillance
KW - EPIDEMIOLOGY
KW - PESTICIDES -- Risk mitigation
KW - INDUSTRIAL safety
KW - DISEASES
KW - CALIFORNIA
KW - CALIFORNIA Environmental Protection Agency. Dept. of Pesticide Regulation
N1 - Accession Number: 9506200462; Ordin, Diana L. 1 Fine, Lawrence J.; Affiliation: 1: Division of Surveillance, Hazard Evolutions, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Jun95, Vol. 85 Issue 6, p762; Subject Term: PUBLIC health surveillance; Subject Term: EPIDEMIOLOGY; Subject Term: PESTICIDES -- Risk mitigation; Subject Term: INDUSTRIAL safety; Subject Term: DISEASES; Subject Term: CALIFORNIA; Company/Entity: CALIFORNIA Environmental Protection Agency. Dept. of Pesticide Regulation; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Houn, Florence
AU - Helzlsouer, Kathy J.
AU - Friedman, Neil B.
AU - Stefanek, Michael E.
T1 - The Practice of Prophylactic Mastectomy: A Survey of Maryland Surgeons.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/06//
VL - 85
IS - 6
M3 - Article
SP - 801
EP - 805
PB - American Public Health Association
SN - 00900036
AB - Objectives. Bilateral prophylactic mastectomy is a drastic breast cancer preventive option for which indications are not standardized and efficacy has not been proven. To estimate the magnitude of this controversial practice, surgeons were surveyed on their recommendations about and performance of prophylactic mastectomy. Methods. A cross-sectional survey was sent to general surgeons (n=522), plastic surgeons (n=80), and gynecologists (n=801) licensed to practice in Maryland in 1992. Proportions responding were 41.9%, 66.3%, and 54.9%, respectively. In addition, there were 30 respondents who identified "other" as their specialty. The respondents were asked about the role of bilateral prophylactic mastectomy and the number of time they had recommended and performed it in a year. Results. Seven hundred forty-two surgeons responded (51.8%). More plastic surgeons (84.6%) than general surgeons (47.0%) and gynecologists (38.3%) agreed that bilateral prophylactic mastectomy has a role in the care of high-risk women. Eighty-one percent of plastic surgeons had recommended the procedure, compared with 38.8% of general surgeons and 17.7% of gynecologists. Conclusions. Indications and practice patterns reveal heterogeneity of medical opinion and practice of prophylactic mastectomy. This study raises the need for better evaluation of the efficacy and appropriateness of prophylactic mastectomy. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASTECTOMY
KW - BREAST cancer -- Surgery
KW - BREAST cancer
KW - SURGEONS
KW - SURVEYS
KW - PLASTIC surgery
N1 - Accession Number: 9506200481; Houn, Florence 1,2 Helzlsouer, Kathy J. 3,4 Friedman, Neil B. 5 Stefanek, Michael E. 4; Affiliation: 1: Division of Mammography Quality and Radiation Programs, Food and Drug Administration, Rockville, Md 2: Oncology Center, Johns Hopkins Hospital, Baltimore, Md 3: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health 4: Oncology Center, Johns Hopkins Hospital 5: Department of Surgery, Johns Hopkins Hospital; Source Info: Jun95, Vol. 85 Issue 6, p801; Subject Term: MASTECTOMY; Subject Term: BREAST cancer -- Surgery; Subject Term: BREAST cancer; Subject Term: SURGEONS; Subject Term: SURVEYS; Subject Term: PLASTIC surgery; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waldman, Robert J.
T1 - Peacekeeping: Challenges for the Future.
JO - Armed Forces & Society (0095327X)
JF - Armed Forces & Society (0095327X)
Y1 - 1995///Summer95
VL - 21
IS - 4
M3 - Book Review
SP - 677
EP - 679
PB - Sage Publications Inc.
SN - 0095327X
AB - The article reviews the book "Peacekeeping: Challenges for the Future," edited by Hugh Smith.
KW - PEACEKEEPING forces
KW - NONFICTION
KW - SMITH, Hugh
KW - PEACEKEEPING: Challenges for the Future (Book)
N1 - Accession Number: 9508230647; Waldman, Robert J. 1; Affiliation: 1: Office of the Assistant Secretary for Health, U.S. Public Health Service; Source Info: Summer95, Vol. 21 Issue 4, p677; Subject Term: PEACEKEEPING forces; Subject Term: NONFICTION; Reviews & Products: PEACEKEEPING: Challenges for the Future (Book); People: SMITH, Hugh; Number of Pages: 3p; Document Type: Book Review; Full Text Word Count: 809
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Hanlon, T. P.
AU - Messersmith, W. A.
AU - Dalakas, M. C.
AU - Plot, P. H.
AU - Miller, F. W.
T1 - γδ T cell receptor gene expression by muscle-infiltrating lymphocytes in the idiopathic inflammatory myopathies.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 1995/06//
VL - 100
IS - 3
M3 - Article
SP - 519
EP - 528
PB - Wiley-Blackwell
SN - 00099104
AB - Autoreactive αβ T cells have been implicated as playing a primary pathogenic role in a group of diseases characterized by chronic muscle inflammation known as the idiopathic inflammatory myopathies (IIM). γδ T cells, a distinct and enigmatic class of 'T cells, play a less certain role in a variety of human autoimmune diseases including the IIM. In an attempt to understand the significance of γδ T cells in the IIM, we utilized a sensitive polymerase chain reaction (PCR) technique to evaluate γδ T cell receptor (TCR) gene expression in 45 muscle biopsies obtained from 42 IIM patients (17 polymyositis. 12 dermatomyositis, and 13 inclusion body myositis). γδ TCR gene expression was not detected in 36 specimens, the majority of muscle biopsies surveyed. γδ TCR gene expression by muscle-infiltrating lymphocytes was detected among nine clinically heterogeneous patients. We further analysed the functional sequence composition of the Vγ3 and Vδ1 transcripts, whose expression was prominent among γδ positive patients. DNA sequence analysis of Vγ3 amplification products from two patients revealed the presence of several productively rearranged transcripts with amino acid sequence similarities within the Vγ3-N-Jγ junctional domain. No amino acid sequence similarities were evident within the Vδ-N-Dδ-N-Jδ region of Vδ1 transcripts amplified from four patients, although a distinct and dominant clonotype was detected from each patient. Our cumulative data suggest that unlike αβ T cells, γδ T cells do not play a prominent pathologic role in the IIM. In fact, the sporadic nature of γδ TCR gene expression detected among these patients implies that γδ T cell infiltration, when it occurs, is a secondary event perhaps resulting from non-specific inflammatory processes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - CELL receptors
KW - LYMPHOCYTES
KW - INFLAMMATION
KW - MUSCLES
KW - POLYMYOSITIS
KW - γ&delta T cells
KW - myositis
KW - T cell receptors
N1 - Accession Number: 16194786; O'Hanlon, T. P. 1 Messersmith, W. A. 1 Dalakas, M. C. 2 Plot, P. H. 3 Miller, F. W. 1; Affiliation: 1: Molecular Immunology Laboratory, Centre for Biologies Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD, USA. 2: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. 3: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.; Source Info: Jun1995, Vol. 100 Issue 3, p519; Subject Term: T cells; Subject Term: CELL receptors; Subject Term: LYMPHOCYTES; Subject Term: INFLAMMATION; Subject Term: MUSCLES; Subject Term: POLYMYOSITIS; Author-Supplied Keyword: γ&delta T cells; Author-Supplied Keyword: myositis; Author-Supplied Keyword: T cell receptors; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trout, Douglas
AU - Gomez, Thomas M.
AU - Bernard, Bruce P.
AU - Mueller, Charles A.
AU - Smith, C Gregory
AU - Hunter, Lee
AU - Kiefer, Max
T1 - Outbreak of Brucellosis at a United States Pork Packing Plant.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/06//
VL - 37
IS - 6
M3 - Article
SP - 697
EP - 703
SN - 00961736
AB - In 1992, the North Carolina Department of Environment, Health, and Natural Resources received 18 case reports of brucellosis from a county health department. All patients had potential exposure to the kill floor of one pork processing plant. A subsequent National Institute for Occupational Safety and Health health hazard evaluation surveyed 154 (99%) of 156 kill floor workers of this plant and found that 30 (19%) had evidence of recent (or persistent) brucellosis. These data show that significant exposure to Brucella is occurring among packing plant workers in North Carolina and suggest that some of the approximately 38,000 production workers in pork processing plants in the United States are at risk of contracting swine brucellosis. Additional measures may need to be taken to prevent occupational exposure to Brucella. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379836; Trout, Douglas 1 Gomez, Thomas M. 1 Bernard, Bruce P. 1 Mueller, Charles A. 1 Smith, C Gregory 1 Hunter, Lee 1 Kiefer, Max 1; Affiliation: 1: 1 From the North Carolina Department of Environment, Health, and Natural Resources, Atlanta, Georgia 2 From the Animal and Plant Health Inspection Service, United States Department of Agriculture, Atlanta, Georgia 3 From the Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, Georgia, and Cincinnati, Ohio; Source Info: Jun1995, Vol. 37 Issue 6, p697; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Amandus, H E
AU - Hunter, R D
AU - James, E
AU - Hendricks, S
T1 - Reevaluation of the Effectiveness of Environmental Designs to Reduce Robbery Risk in Florida Convenience Stores.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/06//
VL - 37
IS - 6
M3 - Article
SP - 711
EP - 717
SN - 00961736
AB - Prevention of intentional injuries to convenience store workers has focused on prevention of robbery. Data from a cross-sectional study of the effectiveness of environmental designs to deter robbery in Florida convenience stores were reanalyzed in order to determine the effect of confounding from local crime risk factors and other environmental designs on robbery rate. Results of this reanalysis were applied to a review of the literature.Of 14 store design factors and 5 local crime risk factors considered, concealed access/escape routes, cash register located at the back or the side of the store, high county crime rate, and high county population size were significantly associated with increased robbery rate. Poor cash handling policy was significantly related to a decreased robbery rate. Results also indicated that local crime factors and some environmental designs confound the relationship between other environmental designs and robbery rate.Conclusions from this reanalysis indicated that studies of the effectiveness of environmental designs to deter robbery must adjust for confounding. Although environmental design tends to be an effective robbery deterrent strategy, results from studies have been inconsistent as to the effectiveness of specific design factors. This inconsistency is partially explained by lack of adjustment for confounding from local crime risk factors and multiple environmental design factors. Areas for further research are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379839; Amandus, H E 1 Hunter, R D 1 James, E 1 Hendricks, S 1; Affiliation: 1: 1 From the National Institute for Occupational Safety and Health, Morgantown, West Virginia 2 From Jacksonville State University, Jacksonville, Alabama 3 From Purdue University Calumet, Hammond, Indiana; Source Info: Jun1995, Vol. 37 Issue 6, p711; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Elders, M. Joycelyn
T1 - The Role of Public Health in Improving the Health of America.
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 1995///Summer1995
VL - 16
IS - 2
M3 - Article
SP - 133
EP - 141
SN - 01975897
AB - The article is a keynote address by the author to the members of American Public Health Association. He thanks all the members for their contribution to the public health. He thanked the members for their role in prevention of epidemics, protecting environment, preventing spread of HIV disease,and preventing unintentional injuries. He also mentions their response to the natural disasters has been commendable. He discusses the floods at Georgia, that caused havoc, as water level reached roof top of the buildings. He was impressed with courage, hope and resiliency, that community has put their lives back together. He suggests that one has to continuously strive to face the challenges due to poverty. He says that future focus should lie on preventive aspects. He says that to have access to high quality healthcare to the poor should be the motive. He says that the professionals must reach out and be responsible, be willing to take some risks. They must continue with high quality research and try to develop a vaccine for HIV. Professionals must make endeavors to educate themselves and the community to be healthy Americans.
KW - MEDICAL care -- United States
KW - PUBLIC health
KW - NATURAL disasters
KW - PROFESSIONAL ethics
KW - AIDS (Disease) -- Prevention
KW - UNITED States
KW - American Public Health Association
KW - Keynote address
KW - Public health status
KW - Statistics
KW - USA
KW - AMERICAN Public Health Association
N1 - Accession Number: 8181865; Elders, M. Joycelyn 1; Affiliation: 1: Surgeon General, U.S. Public Health Service.; Source Info: Summer1995, Vol. 16 Issue 2, p133; Subject Term: MEDICAL care -- United States; Subject Term: PUBLIC health; Subject Term: NATURAL disasters; Subject Term: PROFESSIONAL ethics; Subject Term: AIDS (Disease) -- Prevention; Subject Term: UNITED States; Author-Supplied Keyword: American Public Health Association; Author-Supplied Keyword: Keynote address; Author-Supplied Keyword: Public health status; Author-Supplied Keyword: Statistics; Author-Supplied Keyword: USA; Company/Entity: AMERICAN Public Health Association; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Infant Mortality in the United States: Trends, Differentials, and Projections, 1950 through 2010.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/07//
VL - 85
IS - 7
M3 - Article
SP - 957
EP - 964
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined long-term trends and differences in infant mortality in the United States from 1950 through 1991 according to race and ethnicity, education, family income, and cause of death. Forecasts are made through the year 2010. Methods. Los-linear regression models were applied to data from the National Vital Statistics System, National Linked Birth and Infant Death files, the National Maternal and Infant Health Survey, the National Natality Survey, and the National Infant Mortality Survey to model and forecast infant mortality. Results. Dramatic declines in the US infant mortality rate have occurred in the past 4 decades, largely as a result of declines in mortality from pneumonia and influenza, respiratory distress syndrome, prematurity and low birthweight, congenital anomalies, and accidents. Despite the overall reductions, however, substantial racial/ethnic, educational, and income differences in infant mortality still exist. Conclusions. The long-term downward trend in US infant mortality has not benefited Blacks and Whites equally. The Black/White disparity in infant mortality has not only persisted but increased over time and is not expected to diminish in the near future. Educational inequalities have also widened, and racial disparities have generally increased across all educational levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT mortality
KW - REGRESSION analysis
KW - RACE
KW - ETHNICITY
KW - RESPIRATORY distress syndrome
KW - LOW birth weight
KW - HEALTH surveys
KW - UNITED States
KW - HEALTH—MEDICAL
N1 - Accession Number: 9508091232; Singh, Gopal K. 1 Yu, Stella M. 2; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md; Source Info: Jul1995, Vol. 85 Issue 7, p957; Subject Term: INFANT mortality; Subject Term: REGRESSION analysis; Subject Term: RACE; Subject Term: ETHNICITY; Subject Term: RESPIRATORY distress syndrome; Subject Term: LOW birth weight; Subject Term: HEALTH surveys; Subject Term: UNITED States; Author-Supplied Keyword: HEALTH—MEDICAL; Number of Pages: 8p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anttila, Ahti
AU - Pukkala, Eero
AU - Sallmén, Markku
AU - Hernberg, Sven
AU - Hemminki, Kari
T1 - Cancer Incidence among Finnish Workers Exposed to Halogenated Hydrocarbons.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/07//
VL - 37
IS - 7
M3 - Article
SP - 797
EP - 806
SN - 00961736
AB - Epidemiologic studies and long-term carcinogenicity studies in experimental animals suggest that some halogenated hydrocarbons are carcinogenic. To investigate whether exposure to trichloroethylene, tetrachloroethylene, or 1,1,1-trichloroethane increases carcinogenic risk, a cohort of 2050 male and 1924 female workers monitored for occupational exposure to these agents was followed up for cancer incidence in 1967 to 1992. The overall cancer incidence within the cohort was similar to that of the Finnish population. There was an excess of cancers of the cervix uteri and lymphohematopoietic tissues, however. Excess of pancreatic cancer and non-Hodgkin lymphoma was seen after 10 years from the first personal measurement. Among those exposed to trichloroethylene, the overall cancer incidence was increased for a follow-up period of more than 20 years. There was an excess of cancers of the stomach, liver, prostate, and lymphohematopoietic tissues combined. Workers exposed to 1,1,1-trichloroethane had increased risk of multiple myeloma and cancer of the nervous system. The study provides support to the hypothesis that trichloroethylene and other halogenated hydrocarbons are carcinogenic for the liver and lymphohematopoietic tissues, especially for non-Hodgkin lymphoma. The study also documents excess of cancers of the stomach, pancreas, cervix uteri, prostate, and the nervous system among workers exposed to solvents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379815; Anttila, Ahti 1 Pukkala, Eero 1 Sallmén, Markku 1 Hernberg, Sven 1 Hemminki, Kari 1; Affiliation: 1: From the Finnish Institute of Occupational Health (Dr Anttila, Mr Sallmén, Dr Hernberg, Dr Hemminki) and the Finnish Cancer Registry (Dr Pukkala), Helsinki, Finland. The present affiliation of Dr Hemminki is the Center for Nutrition and Toxicology, Karolinska Institute, Huddinge, Sweden. The study on cancer incidence was financed by a grant from the Finnish Work Environment Fund. The collection of the biologic monitoring data has been supported by the US National Institute for Occupational Safety and Health.; Source Info: Jul1995, Vol. 37 Issue 7, p797; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lee, Philip R.
T1 - Public policy issues: an American perspective.
JO - Journal of the Royal Society of Medicine (Supplement)
JF - Journal of the Royal Society of Medicine (Supplement)
Y1 - 1995/07//
VL - 88
IS - 26
M3 - Editorial
SP - 4
EP - 6
SN - 02675331
AB - The article presents the author's perspective on health care reform and public health policy in the U.S. The U.S. Congress, the executive branch and the public are trying to address issues that are fundamental to health care reform. There are several elements that can result to health care reform. The U.S. Congress are introducing several initiatives in order to strengthen the public health and personal care systems.
KW - HEALTH care reform
KW - PUBLIC health
KW - MEDICAL policy
KW - MEDICAL care -- Law & legislation
KW - UNITED States
KW - health care reform
KW - public health policy
N1 - Accession Number: 23996768; Lee, Philip R. 1; Affiliation: 1: Assistant Secretary for Health, Administrator, US Public Health Service, US Department of Health & Human Services, Washington, DC, USA; Source Info: Jul1995, Vol. 88 Issue 26, p4; Subject Term: HEALTH care reform; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: MEDICAL care -- Law & legislation; Subject Term: UNITED States; Author-Supplied Keyword: health care reform; Author-Supplied Keyword: public health policy; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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ER -
TY - JOUR
AU - Steenland, Kyle
AU - Brown, David
T1 - Silicosis among Gold Miners: Exposure-Response Analyses and Risk Assessment.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1995/10//
VL - 85
IS - 10
M3 - Article
SP - 1372
EP - 1377
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study sought to estimate the risk of silicosis by cumulative exposure-years in cohort of miners exposed to silica as well as the lifetime risk of silicosis under the current. Occupational safety and Health Administration (OSHA) standard (0.09 mg/m³) Methods. In a cohort study of 3330 gold miners who worked at least 1 year undergone from 1940 to 1965 (average 9 years) and were exposed to a median silica level of 0.05 mg/m³ (0.15 mg/m³ for those hired before 1930), 170 cases of silicosis were determined form either death certificates or two crosssectional radiographic surveys. Results. The risk of silicosis was lessthan 1% with a cumulative exposure under 0.5 mg/m³ years. increasing to 68% to 84% for the highest cumulative exposures category of more than 4 mg/m³-years. Cumulative exposure was the best predictor of disease, followed by duration of exposure and average exposure. After adjustment for competing risks of death a 45-year exposure under the current OSHA standard would lead to a lifetime risk of silicosis of 35% to 47%. Conclusions. Almost 2 million US worker are currently exposed to silica. Our results add to a small but increasing body of literature that suggest that the current OSHA silica exposure level is unacceptably high. [ABSTRACT FROM AUTHOR]
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KW - SILICOSIS
KW - LUNGS -- Dust diseases
KW - MINERS
KW - SILICA
KW - OCCUPATIONAL diseases
N1 - Accession Number: 9510240233; Steenland, Kyle 1 Brown, David 2; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: National institute for Environmental Health Science Research Triangle Park, NC; Source Info: Oct95, Vol. 85 Issue 10, p1372; Subject Term: SILICOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: MINERS; Subject Term: SILICA; Subject Term: OCCUPATIONAL diseases; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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ER -
TY - JOUR
AU - Johnston, Janet J.
T1 - Occupational Injury and Stress.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1995/10//
VL - 37
IS - 10
M3 - Article
SP - 1199
EP - 1203
SN - 00961736
AB - A literature search was conducted to identify studies that measured the relationship between stress and occupational injury. Studies that provided a quantitative measure of stress and occupational injury and a quantitative assessment of the relationship between these two factors were selected for this review. Twenty studies were identified, and all had P values of less than .05 or odds ratios ranging from .3 to 4.6. Twelve of 17 measures had odds ratios greater than 1.0. Several factors limit the generalizability of these results, however, and these include methodological differences in the assessment of stress and injury, study design, and limited representation of occupations. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113379769; Johnston, Janet J. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia. Address correspondence to: Dr. Janet J. Johnston, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS1133, Morgantown, WV 26505-2888.; Source Info: Oct1995, Vol. 37 Issue 10, p1199; Number of Pages: 5p; Document Type: Article
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ER -
TY - JOUR
AU - Baker, Karen H.
AU - Cygnarowicz-Provost, Miriam
T1 - WHAT YOU SHOULD KNOW ABOUT STERILIZED EQUIPMENT.
JO - Nursing
JF - Nursing
Y1 - 1995/10//
VL - 25
IS - 10
M3 - Article
SP - 21
EP - 21
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article presents suggestions to ensure that the medical devices are properly sterilized before performing a sterile procedure. Check the expiration date, load label, and internal and external chemical indicators of the medical device. Precautions must be taken when opening and handling sterile items. INSET: How it's done (sterilization methods)..
KW - MEDICAL equipment
KW - STERILIZATION (Disinfection)
KW - DISINFECTION & disinfectants
KW - BIOLOGICAL decontamination
KW - MEDICAL supplies
N1 - Accession Number: 9511074663; Baker, Karen H. 1 Cygnarowicz-Provost, Miriam 2; Affiliation: 1: Nurse-Consultant, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md. 2: Chemical Engineer, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md.; Source Info: Oct95, Vol. 25 Issue 10, p21; Subject Term: MEDICAL equipment; Subject Term: STERILIZATION (Disinfection); Subject Term: DISINFECTION & disinfectants; Subject Term: BIOLOGICAL decontamination; Subject Term: MEDICAL supplies; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 1p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Comas-Díaz, Lillian
AU - Jansen, Mary A.
T1 - Global Conflict and Violence Against Women.
JO - Peace & Conflict
JF - Peace & Conflict
Y1 - 1995/12//
VL - 1
IS - 4
M3 - Article
SP - 315
SN - 10781919
AB - Global and local conflicts often emerge due to sociopolitical changes. Many of these changes entail negative consequences to women, usually in the form of violence against them. This article describes some of the oppressive conditions of women living in technologically underdeveloped and developed countries, as well as in war and state-sponsored violence areas. Special attention is also given to the gender-specific violence experienced by refugee women. A review of women's reactions to oppression and violence suggests that many cope with their grief through creative transformation. Women's resistance movements and their contributions to the liberation and peace process embody female forms of empowerment. This article discusses feminine movements such as las madres (mothers), campesinas (peasants), Amazonas (Amazons), and arpilleras (women who make arpilleras--cloth pictures) as examples of female empowerment in the midst of violence. We conclude that women's resistance against violence has altered our discourse of culture, gender, and politics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Peace & Conflict is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN -- Social conditions
KW - WOMEN in politics
KW - WOMEN -- Crimes against
KW - VIOLENCE
KW - AGGRESSION (Psychology)
KW - GENDER
N1 - Accession Number: 7332207; Comas-Díaz, Lillian 1 Jansen, Mary A. 2; Affiliation: 1: Transcultural Mental Health Institute, Washington, DC. 2: Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Washington, DC.; Source Info: 1995, Vol. 1 Issue 4, p315; Subject Term: WOMEN -- Social conditions; Subject Term: WOMEN in politics; Subject Term: WOMEN -- Crimes against; Subject Term: VIOLENCE; Subject Term: AGGRESSION (Psychology); Subject Term: GENDER; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stout, Nancy A.
AU - Jenkins, E. Lynn
AU - Pizatella, Timothy J.
T1 - Occupational Injury Mortality Rates in the United States: Changes from 1980 to 1989.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/01//
VL - 86
IS - 1
M3 - Article
SP - 73
EP - 73
PB - American Public Health Association
SN - 00900036
AB - Changes in occupational injury mortality rates over the 1980s were examined through analysis of the National Traumatic Occupational Fatalities surveillance system. The US occupational injury mortality rate decreased 37% over the decade, with decreases seen in nearly every demographic and employment sector. Greater declines were among men, Blacks, and younger workers, as well as among agricultural, trade, and service workers. Electrocutions, machine-related incidents, and homicides showed the greatest decreases. Changes in occupational mortality rates by demography, industry, and cause of death indicate the areas in which the most progress has been made and those that are prime targets for prevention efforts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - INDUSTRIAL hygiene
KW - HOMICIDE
KW - DEATH -- Causes
KW - WORK-related injuries
N1 - Accession Number: 9602123524; Stout, Nancy A. 1 Jenkins, E. Lynn 1 Pizatella, Timothy J. 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV; Source Info: Jan1996, Vol. 86 Issue 1, p73; Subject Term: MORTALITY; Subject Term: INDUSTRIAL hygiene; Subject Term: HOMICIDE; Subject Term: DEATH -- Causes; Subject Term: WORK-related injuries; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harkin, Timothy J.
AU - McGuinness, Georgeann
AU - Goldring, Roberta
AU - Cohen, Henry
AU - Parker, John E.
AU - Crane, Michael
AU - Naidich, David P.
AU - Rom, William N.
T1 - Differentiation of the ILO Boundary Chest Roentgenograph (0/1 to 1/0) in Asbestosis by High-Resolution Computed Tomography Scan, Alveolitis, and Respiratory Impairment.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/01//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - High-resolution computed tomography (HRCT) scans have been advocated as providing greater sensitivity in detecting parenchymal opacities in asbestos-exposed individuals, especially in the presence of pleural fibrosis, and having excellent inter- and intraobserver reader interpretation. We compared the 1980 International Labor Organization (ILO) International Classification of the Radiographs of the Pneumoconioses for asbestosis with the high-resolution CT scan using a grid scoring system to better differentiate normal versus abnormal in the ILO boundary 0/1 to 1/0 chest roentgenograph. We studied 37 asbestos-exposed individuals using the ILO classification, HRCT grid scores, respiratory symptom questionnaires, pulmonary function tests, and bronchoalveolar lavage. We used Pearson correlation coefficients to evaluate the linear relationship between outcome variables and each roentgenographic method. The normal HRCT scan proved to be an excellent predictor of "normality," with pulmonary function values close to 100% for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLCO) and no increase in BAL inflammatory cells. Concordant HRCT/ILO abnormalities were associated with reduced FEV1/FVC ratio, reduced diffusing capacity, and alveolitis consistent with a definition of asbestosis. In our study, the ILO classification and HRCT grid scores were both excellent modalities for the assessment of asbestosis and its association with impaired physiology and alveolitis, with their combined use providing statistical associations with alveolitis and reduced diffusing capacity. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113635105; Harkin, Timothy J. 1 McGuinness, Georgeann 1 Goldring, Roberta 1 Cohen, Henry 1 Parker, John E. 2 Crane, Michael Naidich, David P. Rom, William N. 1; Affiliation: 1: Division of Pulmonary and Critical Care Medicine, New York University Medical Center, 550 First Avenue, New York, NY 10016. 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Source Info: Jan1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4301
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pratt, Stephanie G.
AU - Kisner, Suzanne M.
AU - Helmkamp, James C.
T1 - Machinery-Related Occupational Fatalities in the United States, 1980 to 1989.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/01//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - The National Traumatic Occupational Fatalities surveillance system identified machinery-related incidents as the second leading cause of traumatic occupational fatalities in the United States between 1980 and 1989. These incidents resulted in 8,505 civilian worker deaths and an average annual fatality rate of .80 per 100,000 workers. Workers aged 65 years and older had 5.8 times the fatality rate of workers aged 16 to 64 years (4.06 vs .70). The highest industry-specific rate was noted in agriculture, forestry, and fishing (7.47). Tractors and other agricultural machinery were associated with nearly 9 of every 10 fatal machinery-related incidents involving workers aged 65 or older. Although numerous studies of agricultural machinery-related fatalities are found in the literature, detailed analyses of machinery-related fatalities in the construction industry as well as analyses of work situations and risk factors associated with fatal injuries are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635108; Pratt, Stephanie G. 1 Kisner, Suzanne M. 1 Helmkamp, James C. 1; Affiliation: 1: Surveillance and Field Investigations Branch, Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.; Source Info: Jan1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4466
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Occupational Exposure to Chrysotile Asbestos and Cancer Risk: A Review of the Amphibole Hypothesis.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 179
EP - 179
PB - American Public Health Association
SN - 00900036
AB - Objectives. This article examines the credibility and policy implications of the "amphibole hypothesis," which postulates that (1) the mesotheliomas observed among workers exposed to chrysotile asbestos may be explained by confounding exposures to amphiboles, and (2) chrysotile may have lower carcinogenic potency than amphiboles. Methods. A critical review was conducted of the lung burden, epidemiologic, toxicologic, and mechanistic studies that provide the basis for the amphibole hypothesis. Results. Mechanistic and lung burden studies do not provide convincing evidence for the amphibole hypothesis. Toxicologic and epidemiologic studies provide strong evidence that chrysotile is associated with an increased risk of lung cancer and mesothelioma. Chrysotile may be less potent than some amphiboles for inducing mesotheliomas, but there is little evidence to indicate lower lung cancer risk. conclusions. Given the evidence of a significant lung cancer risk, the lack of conclusive evidence for the amphibole hypothesis, and the fact that workers are generally exposed to a mixture of fibers, we conclude that it is prudent to treat chrysotile with virtually the same level of concern as the amphibole forms of asbestos. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPHIBOLES
KW - CHRYSOTILE
KW - ASBESTOS
KW - LUNGS -- Cancer
KW - MESOTHELIOMA
N1 - Accession Number: 9603040361; Stayner, Leslie T. 1 Dankovic, David A. 1 Lemen, Richard A. 1; Affiliation: 1: Risk Assessment Program, Office of the Director, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Feb1996, Vol. 86 Issue 2, p179; Subject Term: AMPHIBOLES; Subject Term: CHRYSOTILE; Subject Term: ASBESTOS; Subject Term: LUNGS -- Cancer; Subject Term: MESOTHELIOMA; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Stella M.
AU - Keppel, Kenneth G.
AU - Singh, Gopal K.
AU - Kessel, Woodie
T1 - Preconceptional and Prenatal Multivitamin-Mineral Supplement Use in the 1998 National Maternal and Infant Health Survey.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 240
EP - 240
PB - American Public Health Association
SN - 00900036
AB - This paper examines the prevalence of multivitamin-mineral supplement use before and during pregnancy, as well as predictors of nonuse, in 9953 women who delivered live infants in the 1988 National Maternal and Infant Health Survey. Ninety-seven percent of the women were advised to take multivitamin-mineral supplements in prenatal care. Sixty- seven percent of Black mothers took supplements during pregnancy, as compared with 84% of White mothers. Multivariate analysis revealed that Black mothers; mothers who are less educated, younger, unmarried, and non-smokers; and mothers who participate in Women, Infants, and Children programs are at elevated risk for nonuse. These data help identify groups in need of supplementation guidance. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - VITAMINS
KW - PREGNANT women
KW - PREGNANCY
KW - INFANTS
N1 - Accession Number: 9603040388; Yu, Stella M. 1 Keppel, Kenneth G. 2 Singh, Gopal K. 3 Kessel, Woodie 1; Affiliation: 1: Division of Science, Education and Analysis, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md. 2: Division of Health Promotion Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md. 3: Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md.; Source Info: Feb1996, Vol. 86 Issue 2, p240; Subject Term: DIETARY supplements; Subject Term: VITAMINS; Subject Term: PREGNANT women; Subject Term: PREGNANCY; Subject Term: INFANTS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kahn, Laura H.
AU - Blustein, Jan
AU - Arons, Raymond R.
AU - Yee, Raymond
AU - Shea, Steven
T1 - The Validity of Hospital Administrative Data in Monitoring Variations in Breast Cancer Surgery.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/02//
VL - 86
IS - 2
M3 - Article
SP - 243
EP - 243
PB - American Public Health Association
SN - 00900036
AB - To assess the validity of using hospital administrative data to measure variations in surgery for early-stage breast cancer, ICD-9-CM coded information was compared with corresponding tumor registry data for 1293 breast cancer patients undergoing lumpectomy or mastectomy at a tertiary referral center from January 1989 to October 1993. Relative to "gold standard" tumor registry data, the administrative data proved 83.4% sensitive and 80.4% specific in identifying women with localized disease who would be potential candidates for lumpectomy. The proportion of women with localized disease under- going lumpectomy in groups defined by race and insurance status was nearly identical, whichever data were used. Administrative data, which is often readily and publicly available, may be useful in studying variations in breast cancer treatment in key demographic groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL records
KW - BREAST cancer
KW - ONCOLOGIC surgery
KW - TUMORS
KW - LUMPECTOMY
N1 - Accession Number: 9603040391; Kahn, Laura H. 1 Blustein, Jan 2,3 Arons, Raymond R. 3,4 Yee, Raymond 4 Shea, Steven 2,5; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration. Washington, DC 2: Division of General Medicine, Columbia College of Physicians and Surgeons, New York, NY 3: Division of Health Policy and Management, School of Public Health, Columbia University 4: Office of Case Mix Studies, Presbyterian Hospital, New York, NY 5: Division of Epidemiology, School of Public Health, Columbia University; Source Info: Feb1996, Vol. 86 Issue 2, p243; Subject Term: MEDICAL records; Subject Term: BREAST cancer; Subject Term: ONCOLOGIC surgery; Subject Term: TUMORS; Subject Term: LUMPECTOMY; Number of Pages: 3p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Proctor, Enola K.
AU - Morrow-Howell, Nancy
AU - Kaplan, Salley J.
T1 - Implementation of Discharge Plans for Chronically Ill Elders Discharged Home.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1996/02//
VL - 21
IS - 1
M3 - Article
SP - 30
EP - 30
PB - Oxford University Press / USA
SN - 03607283
AB - Although discharge plans are viewed as the primary means to ensure that patients' needs will be met in the posthospital environment, little is known about the implementation of arranged care. This study addressed the extent to which discharge plans for elderly patients with congestive heart failure were implemented as planned, tested the consequences of implementation problems, and identified factors associated with implementation problems. For 40 percent of patients, one or more components of the discharge plan were not implemented as planned, with discrepancies more likely among low-income patients. Implementation discrepancies had negative consequences in terms of unmet needs, deficient quantity of help, and less than adequate care. Implications for hospital discharge planners and home health care are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health & Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH facilities -- Discharge planning
KW - OLDER people -- Health
KW - CHRONICALLY ill
KW - HEART failure
KW - HOME care services
KW - MEDICAL care
KW - adequacy of care
KW - CONGESTIVE HEART FAILURE
KW - discharge planning
KW - elderly people
KW - home health care
KW - informal care
KW - INSTITUTIONAL AND NONINSTITUTIONAL CARE
KW - PROGRAM IMPLEMENTATION
N1 - Accession Number: 9602154233; Proctor, Enola K. 1,2 Morrow-Howell, Nancy 3 Kaplan, Salley J. 4; Affiliation: 1: Frank J. Bruno, Professor of Social Work Research, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, One Brokkings Drive, St. Louis, MO 63030. 2: Director, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, One Brokkings Drive, St. Louis, MO 63030. 3: Associate Professor and Investigator, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, One Brokkings Drive, St. Louis, MO 63030. 4: Senior research associate Lewin-VHI, Inc., Fairfax, VA.; Source Info: Feb1996, Vol. 21 Issue 1, p30; Subject Term: HEALTH facilities -- Discharge planning; Subject Term: OLDER people -- Health; Subject Term: CHRONICALLY ill; Subject Term: HEART failure; Subject Term: HOME care services; Subject Term: MEDICAL care; Author-Supplied Keyword: adequacy of care; Author-Supplied Keyword: CONGESTIVE HEART FAILURE; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: home health care; Author-Supplied Keyword: informal care; Author-Supplied Keyword: INSTITUTIONAL AND NONINSTITUTIONAL CARE; Author-Supplied Keyword: PROGRAM IMPLEMENTATION; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article; Full Text Word Count: 7030
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TY - JOUR
AU - Hankinson, John L.
AU - Kinsley, Kathleen B.
AU - Wagner, Gregory R.
T1 - Comparison of Spirometric Reference Values for Caucasian and African American Blue-Collar Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/02//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - Interpretation of lung-function test results, specifically the forced vital capacity and forced expiratory volume in one second, generally involves the comparison of these parameters with reference values based on an individual's age, height, sex, and race. Such comparisons are often used to make important decisions concerning an individual, such as job placement or disability rating. Several studies[1,2,3] have shown that predicted values for African Americans are approximately 15% less than those for Caucasians, most likely because of the use of standing height to estimate the size of the thorax. When an adjustment for race is applied to reference values based on a Caucasian population, a single value (15%) is usually applied to all individuals.[4,5] When using a group of blue-collar workers (766 Caucasian and 633 African-American subjects) without any race adjustment, 10.2% of the Caucasians and 37.4% of the African-American subjects were below the lower limit of normal. When a single adjustment factor was used, 11.5% of the African-American subjects were below the lower limit of normal. Between-subject variability within an ethnic group was far greater than variability between groups. Our results suggest that although a difference between Caucasian and African-American test results for forced vital capacity and forced expiratory volume in one second exists, an application of a single adjustment factor universally applied to all individuals, regardless of their age, sex, and height, is not optimal, and alternative approaches are needed. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113635128; Hankinson, John L. 1 Kinsley, Kathleen B. 1 Wagner, Gregory R. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia.; Source Info: Feb1996, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 3076
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TY - JOUR
AU - Shults, Ruth A.
AU - Baron, Sherry
AU - Decker, John
AU - Deitchman, Scott D.
AU - Connor, James D.
T1 - Health Care Worker Exposure to Aerosolized Ribavirin.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/03//
M3 - Article
SP - 257
EP - 263
SN - 00961736
AB - Aerosolized ribavirin is administered frequently to treat severe respiratory syncytial virus infections. The drug's potential reproductive effects in occupationally exposed workers remains a concern among health care workers. In this evaluation, we measured urinary ribavirin concentrations in occupationally exposed health care workers. Ribavirin was detected in 16 of 26 (62%) post-work-shift urine samples that had been provided by nurses, and in five of 22 (23%) post-work-shift urine samples that had been provided by respiratory therapists (range, <0.01 to 0.22 µmol/L). We also measured airborne ribavirin concentrations in the personal breathing zones of nurses. Ventilators and other administration units that were enclosed by an aerosol containment tent produced significantly lower airborne ribavirin exposures than administration units without a containment tent did (range, <2.5 to 78 µg/m3). On the basis of this and other evaluations of airborne ribavirin concentrations, we recommend using aerosol containment systems with all types of ribavirin administration units except mechanical ventilators. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113379730; Shults, Ruth A. 1 Baron, Sherry 1 Decker, John 1 Deitchman, Scott D. 1 Connor, James D. 1; Affiliation: 1: From the Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Health Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio (Ms Shults, Dr Baron, Mr Decker, Dr Deitchman), and the Division of Infectious Disease, Department of Pediatrics, University of California-San Diego, La Jolla, California (Dr Connor).; Source Info: Mar1996, p257; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 3997
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TY - JOUR
AU - Banks, Daniel E.
AU - Wang, Mei-Lin
AU - McCabe, Lloyd
AU - Billie, Michael
AU - Hankinson, John
T1 - Improvement in Lung Function Measurements Using a Flow Spirometer that Emphasizes Computer Assessment of Test Quality.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/03//
M3 - Article
SP - 279
EP - 283
SN - 00961736
AB - We compared retrospective measurements of lung function from 101 steel workers using a commercially available spirometer to prospective lung function measurements performed, on average, 1.3 years later, with a newly developed spirometer. This spirometer was designed and developed to incorporate technology that provides immediate feedback on the quantitative and qualitative aspects of each forced expiratory effort. Of the 101 workers, 82 who had spirometry performed with each spirometer had at least two acceptable curves, and 51 workers tested with each spirometer had curves that met all American Thoracic Society (ATS) criteria for spirometry. No group showed the anticipated decline in forced expiratory volume in 1 second (FEV1) over time. The results showed an increased number of curves meeting ATS acceptability and reproducibility criteria, and a statistically significant increase in the FVC in all groups, and an increase in the FEV1 in the group encompassing all workers. Use of technology that strengthens the interaction between the spirometry technician, the data available to the technician on the computer, and the participant appears to represent true underlying lung function more accurately. Such an approach to the collection of lung function data should be considered by those evaluating spirometers for implementation in the workplace or pulmonary function laboratory as well as by those planning future spirometer development. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113379733; Banks, Daniel E. 1 Wang, Mei-Lin 1 McCabe, Lloyd 1 Billie, Michael 1 Hankinson, John 1; Affiliation: 1: From the Section of Pulmonary and Critical Care Medicine, West Virginia University School of Medicine (Drs Banks, Wang, and McCabe, Mr Billie); and the National Institute of Occupational Safety and Health (Dr Hankinson), Morgantown, West Virginia.; Source Info: Mar1996, p279; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 3242
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ER -
TY - JOUR
AU - YETLEY, ELIZABETH A.
AU - RADER, JEANNE I.
T1 - The Challenge of Regulating Health Claims and Food Fortification.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996/03/02/Mar96 Supplement
M3 - Article
SP - 765S
EP - 772S
SN - 00223166
AB - The Food and Drug Administration has several options that will assist the Public Health Ser vice in implementing its September 1992 recommen dation that all women of childbearing age consume 0.4 mg of folie acid daily to reduce their risk of having a pregnancy affected with a neural tube defect. The FDA can authorize the use of a health claim on labels and in the labeling of foods that characterizes the relationship between a nutrient and a health-related condition. For tification of cereal-grain products with folie acid is a second option that has the potential for reaching most women of childbearing age without requiring them to change their food selection patterns. Consideration of these options has been intertwined with rapid develop ments in the scientific database that is the foundation of the health claim, by conflicting opinions regarding the effectiveness for women in the target population of FDA's proposed level of cereal-grain fortification, by lack of systematic safety data regarding the impact of fortification on persons in the general population and by changes in the regulatory environment in which the agency acts. J. Nutr. 126: 765S-772S, 1996. [ABSTRACT FROM AUTHOR]
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KW - folic acid
KW - fortification
KW - health claims
KW - neural tube defects
KW - public policy
N1 - Accession Number: 89382815; YETLEY, ELIZABETH A. 1 RADER, JEANNE I. 2; Affiliation: 1: Office of Special Nutritionab, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204 2: Office of Food Labeling, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204; Source Info: Mar96 Supplement, p765S; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: fortification; Author-Supplied Keyword: health claims; Author-Supplied Keyword: neural tube defects; Author-Supplied Keyword: public policy; Number of Pages: 8p; Document Type: Article; Language: Spanish
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ER -
TY - JOUR
AU - SHANK, FRED R.
AU - CARSON, KAREN
AU - GLINSMANH, WALTER H.
T1 - Putting Things in Perspective: Building on Our Experience.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1996/03/02/Mar96 Supplement
M3 - Article
SP - 781S
EP - 787S
SN - 00223166
AB - The science and policy underlying food labeling and food fortification have evolved over the past 30 years to a point where dietary guidance and nutrition labeling now provide consumers with highly sophisticated, very specific information about links be tween diet and health. The focus was once on preven tion of nutrient deficiency diseases, but today it is on reducing the risk of chronic diseases and health-re lated conditions. The Nutrition Labeling and Education Act of 1990, with its provisions for authorization of health claims on food labels, has provided a gateway through which a broader realm of nutrition and health information can be made available to consumers. How ever, the interpretation and implementation of the health claim provisions must evolve, based on a strong foundation of supporting science, so that industry may more readily make health information available to con sumers in a form that is easily understood and effec tively used in making their dietary choices. We must develop a database to support claims of beneficial ef fects of food components. We must be assured that the beneficial effects are not outweighed by safety con cerns. And we must develop an environment that is conducive to conducting the research to develop these data. This can only be accomplished through the col laborative efforts of industry, academia, consumers and public health agencies. J. Nutr. 126: 7818- 787S, 1996. [ABSTRACT FROM AUTHOR]
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KW - folic acid
KW - food fortification
KW - food labeling
KW - health claims
N1 - Accession Number: 89382817; SHANK, FRED R. 1,2 CARSON, KAREN 1 GLINSMANH, WALTER H. 1; Affiliation: 1: Food and Drug Administration, U.S. Department of Health and Human Services, Washington, DC 20204 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204; Source Info: Mar96 Supplement, p781S; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: food fortification; Author-Supplied Keyword: food labeling; Author-Supplied Keyword: health claims; Number of Pages: 7p; Document Type: Article; Language: Spanish
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ER -
TY - JOUR
AU - Singh, GopaI K.
AU - Yu, Stella M.
T1 - US Childhood Mortality, 1950 through 1993: Trends and Socioeconomic Differentials.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/04//
VL - 86
IS - 4
M3 - Article
SP - 505
EP - 512
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined trends and differentials in US childhood mortality from 1950 through 1993 according to sex, race/ethnicity, education, family income, and cause of death. Methods. Log-linear, multiple regression, and Cox proportional hazards regression models were applied to the data from the National Vital Statistics System, the National Longitudinal Mortality Study; and the Area Resource File. Results. Substantial declines in US childhood mortality have occurred in the past 4 decades, primarily due to decreases in mortality from unintentional injuries, cancer, pneumonia and influenza, and congenital anomalies. The overall declining trend, however, has been dampened by a twofold to threefold increase in the suicide and homicide rates among children since 1968. Male, Black, American Indian, Hawaiian, and Puerto Rican children and those in the lower socioeconomic strata were at an increased risk of death. conclusions. Increasing trends in mortality from violence, firearm injuries, and human immunodeficiency virus / acquired immunodeficiency syndrome pose a major obstacle to continued declines in US childhood mortality. Reducing socioeconomic disparities and improving access to and use of health care may bring about further declines in overall and injury-related childhood mortality. [ABSTRACT FROM AUTHOR]
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KW - CHILD mortality -- Statistics
KW - MORTALITY
KW - STATISTICS
KW - MEDICAL statistics
KW - MEDICAL care
KW - CHILD health services
KW - UNITED States
N1 - Accession Number: 9605102313; Singh, GopaI K. 1 Yu, Stella M. 2; Affiliation: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md. 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; Source Info: Apr96, Vol. 86 Issue 4, p505; Subject Term: CHILD mortality -- Statistics; Subject Term: MORTALITY; Subject Term: STATISTICS; Subject Term: MEDICAL statistics; Subject Term: MEDICAL care; Subject Term: CHILD health services; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Trends and Differentials in Adolescent and Young Adult Mortality in the United States, 1950 through 1993.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/04//
VL - 86
IS - 4
M3 - Article
SP - 560
EP - 564
PB - American Public Health Association
SN - 00900036
AB - Using data from the National Vital Statistics System and the National Longitudinal Mortality Study, this study examined mortality trends and differentials from 1950 through 1993 among US adolescents and young adults according to sex, race! ethnicity, education, family income, marital status, and cause of death. No appreciable reduction in youth mortality has occurred, especially among men. Declines in youth mortality from accidents have been nearly offset by increases in death rates from homicide, suicide, and firearm injuries. American Indians, Blacks. males, and those with least education and income were at increased risk of both overall and injury-specific youth mortality. [ABSTRACT FROM AUTHOR]
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KW - MEDICAL statistics
KW - MORTALITY -- Statistics
KW - TEENAGERS
KW - DEATH -- Causes
KW - STATISTICS
KW - VITAL statistics
N1 - Accession Number: 9605102338; Singh, Gopal K. 1 Yu, Stella M. 2; Affiliation: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md. 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockviile, Md.; Source Info: Apr96, Vol. 86 Issue 4, p560; Subject Term: MEDICAL statistics; Subject Term: MORTALITY -- Statistics; Subject Term: TEENAGERS; Subject Term: DEATH -- Causes; Subject Term: STATISTICS; Subject Term: VITAL statistics; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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ER -
TY - JOUR
AU - Weibel, Robert E.
AU - Benor, David E.
T1 - Reporting Vaccine-Associated Paralytic Poliomyelitis: Concordance between the CDC and the National Vaccine Injury Compensation Program.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/05//
VL - 86
IS - 5
M3 - Article
SP - 734
EP - 734
PB - American Public Health Association
SN - 00900036
AB - This paper compares cases of paralytic poliomyelitis reported to the systems operated by the National Vaccine Injury Compensation Program and the Centers for Disease Control and Prevention (CDC) for reporting of adverse events associated with vaccination. Of the 118 cases of vaccine-associated paralytic poliomyelitis determined by either system, 18 were reported initially only to the compensation program, 50 only to the CDC, and 50 to both. The annual incidence of vaccine-associated paralytic poliomyelitis determined from data from both systems varied from 6 to 13 cases (mean = 9.1) a year, with an increase of 1.4 cases a year when initial reports only to the compensation program are included. Thus, the compensation program provides important supplemental incidence data. [ABSTRACT FROM AUTHOR]
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KW - POLIOMYELITIS vaccine
KW - POLIO -- Prevention
KW - VACCINATION
KW - COMMUNICABLE diseases -- Prevention
KW - IMMUNIZATION
KW - PUBLIC health
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 9606201951; Weibel, Robert E. 1 Benor, David E. 2; Affiliation: 1: National Vaccine Injury Compensation Program, Health Resources and Services Administration, Rockville, Md 2: Office, General Counsel, US Department of Health and Human Services, Rockville, Md; Source Info: May96, Vol. 86 Issue 5, p734; Subject Term: POLIOMYELITIS vaccine; Subject Term: POLIO -- Prevention; Subject Term: VACCINATION; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: IMMUNIZATION; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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ER -
TY - JOUR
AU - Morrow-Howell, Nancy
AU - Chadiha, Letha A.
AU - Proctor, Enola K.
AU - Hourd-Bryant, Maggie
AU - Dore, Peter
T1 - RACIAL DIFFERENCES IN DISCHARGE PLANNING.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1996/05//
VL - 21
IS - 2
M3 - Article
SP - 131
EP - 131
PB - Oxford University Press / USA
SN - 03607283
AB - Given previously reported findings of racial differences in elderly people's use of posthospital care, this article focuses on discharge planning processes as explanations of differential service utilization. We studied the discharge plans for 369 African American and white elderly patients and examined options pursued for posthospital care by social workers, patients, and families for evidence of racial differences. We also looked for racial differences in ruling out nursing home care for reasons of patient and family preference. Discharge planning with African American patients and family members involved less pursuit of nursing home care and more pursuit of formal services in the home than planning with white patients and families. Implications for practice and future research are discussed. [ABSTRACT FROM AUTHOR]
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KW - DISCRIMINATION in medical care
KW - RACE discrimination
KW - HEALTH facilities -- Discharge planning
KW - AFRICAN Americans
KW - OLDER people
KW - NURSING home care
KW - African Americans
KW - discharge planning
KW - elderly people
KW - posthospital care
KW - racial differences
N1 - Accession Number: 9604261374; Morrow-Howell, Nancy 1; Email Address: nancymh@gwbssw.whstl.edu Chadiha, Letha A. 2 Proctor, Enola K. 3,4 Hourd-Bryant, Maggie Dore, Peter; Affiliation: 1: Associate Professor, George Warren Brown School of Social Work, Washington University, Campus Box 1196, One Brookings Drive, St. Louis, MO 63130-4899. 2: Assistant Professor, Center for Mental Health Services Research, Washington University , St. Louis. 3: Frank J. Bruno Professor of Social Work Research, Center for Mental Health Services Research, Washington University , St. Louis. 4: Director, Center for Mental Health Services Research, Washington University , St. Louis.; Source Info: May1996, Vol. 21 Issue 2, p131; Subject Term: DISCRIMINATION in medical care; Subject Term: RACE discrimination; Subject Term: HEALTH facilities -- Discharge planning; Subject Term: AFRICAN Americans; Subject Term: OLDER people; Subject Term: NURSING home care; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: posthospital care; Author-Supplied Keyword: racial differences; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6076
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ER -
TY - JOUR
AU - Franzblau, Alfred
AU - Rock, Cheryl L.
AU - Werner, Robert A.
AU - Albers, James W.
AU - Kelly, Matthew P.
AU - Johnston, Elizabeth C.
T1 - The Relationship of Vitamin B6 Status to Median Nerve Function and Carpal Tunnel Syndrome Among Active Industrial Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/05//
M3 - Article
SP - 485
EP - 491
SN - 00961736
AB - Case reports and small case series suggest that vitamin B6 deficiency is an important etiologic factor in carpal tunnel syndrome (CTS). This hypothesis has never been examined in a randomly selected study population, particularly among active workers. We examined 125 randomly selected active workers from two industrial plants. Each worker completed a self-administered symptom questionnaire and underwent electrodiagnostic testing of the median and ulnar sensory nerves. Laboratory biochemical analyses of vitamin B6 status were also performed using the erythrocyte glutamic pyruvic transaminase assay, and quantification of plasma pyridoxal-5' phosphate. Measurements of vitamin B6 status were unrelated to self-reported symptoms potentially consistent with CTS, electrophysiologically determined median or ulnar nerve function, and CTS defined on the basis of self-reported symptoms and electrophysiologic measurements. These results suggest that CTS among active industrial workers is unrelated to vitamin B6 status. Furthermore, in our opinion, empiric prescription of vitamin B6 to patients with CTS is unwarranted and potentially hazardous. [ABSTRACT FROM AUTHOR]
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N1 - Accession Number: 113379605; Franzblau, Alfred 1 Rock, Cheryl L. 1 Werner, Robert A. 1 Albers, James W. 1 Kelly, Matthew P. 1 Johnston, Elizabeth C. 1; Affiliation: 1: From the Department of Environmental and Industrial Health (Dr Franzblau, Dr Werner, Dr Albers, and Ms Johnston) and the Program in Human Nutrition (Dr Rock, Mr Kelly), the University of Michigan School of Public Health, Ann Arbor, Michigan; the Physical Medicine and Rehabilitation Service, Veterans Administration Medical Center, and the Department of Physical Medicine and Rehabilitation, University of Michigan School of Medicine, Ann Arbor, Michigan (Dr Werner); and the Department of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan (Dr Albers). The contents of this study are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute for Occupational Safety and Health.; Source Info: May1996, p485; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4285
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ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Yu, Stella M.
T1 - Adverse Pregnancy Outcomes: Differences Between US- and Foreign-Born Women in Major US Racial and Ethnic Groups.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Article
SP - 837
EP - 837
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined whether there were significant differentials between US-born and foreign-born women in risks of infant mortality, low birthweight, and preterm birth and whether these differentials, if they existed, varied across major US racial/ethnic groups. Methods. Multivariate logistic regression was applied to national linked birth/infant death records for 1985 through 1987 to estimate overall and ethnic-specific maternal nativity effects on pregnancy outcomes. Results. Substantial maternal nativity differences in risks of infant mortality and low birthweight were found, with the magnitude of the nativity effect varying significantly across racial/ethnic groups. Overall, foreign-born status was associated with 7% and 20% lower risks of low birthweight and infant mortality, respectively. However, the reduced risk of adverse pregnancy outcome associated with immigrant status tended to be substantially larger for Blacks, Cubans, Mexicans, and Chinese than for other ethnic groups. Conclusions. Maternal nativity status, along with ethnicity, may serve as an important axis of differentiation in birth outcome studies. Further research needs to be conducted to assess the effects of behavioral, cultural, and psychosocial factors in explaining the nativity differentials observed here. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LABOR complications (Obstetrics)
KW - INFANT mortality
KW - LOW birth weight
KW - PREMATURE labor
KW - WOMEN
KW - UNITED States
N1 - Accession Number: 9607016047; Singh, Gopal K. 1 Yu, Stella M. 2; Affiliation: 1: Division of Vital Statistics, National Center for Health Statistics, Hyattsville, Md 2: Bureau of Maternal and Child Health, Health Resources and Services Administration, Rockvillle, Md; Source Info: Jun96, Vol. 86 Issue 6, p837; Subject Term: LABOR complications (Obstetrics); Subject Term: INFANT mortality; Subject Term: LOW birth weight; Subject Term: PREMATURE labor; Subject Term: WOMEN; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, H. Irene
AU - Haugh, Gilbert S.
AU - Price-Green, Patricia A.
AU - Dhara, V. Ramana
AU - Kaye, Wendy E.
T1 - Risk Factors for Hazardous Substance Releases that Result in Injuries and Evacuations: Data From 9 States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Article
SP - 855
EP - 855
PB - American Public Health Association
SN - 00900036
AB - This study was undertaken to determine risk factors associated: with hazardous substance releases (at fixed facilities or during transport) that have public health consequences. Data from nine states with surveillance systems for such releases and their consequences were analyzed. Risk factors were determined for releases resulting in (1) injuries or (2) evacuations. Both outcomes were more likely to occur as a result of facility releases (odds ratio [OR] = 1.89,95% confidence interval (CI] = 1.44, 2.47 for injuries; OR = 3.29, 95% CI = 2.28, 4.74, for evacuations). Releases of ammonia, chlorine, and acids resulted in injuries and evacuations more frequently than releases of other substances. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAZARDOUS substances
KW - HEALTH risk assessment
KW - WOUNDS & injuries
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 9607016062; Hall, H. Irene 1 Haugh, Gilbert S. 2 Price-Green, Patricia A. 1 Dhara, V. Ramana 1 Kaye, Wendy E. 1; Affiliation: 1: Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Ga 2: The Orkand Corp, Atlanta; Source Info: Jun96, Vol. 86 Issue 6, p855; Subject Term: HAZARDOUS substances; Subject Term: HEALTH risk assessment; Subject Term: WOUNDS & injuries; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Bright, Roselie A.
AU - Moore Jr., Roscoe M.
T1 - Estimating the prevalence of women with breast implants.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/06//
VL - 86
IS - 6
M3 - Letter
SP - 891
EP - 891
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "The Estimated Frequency of Cosmetic Breast Augmentation Among U.S. Women, 1963 Through 1988," by M. B. Terry, M. L. Skovron and E. Sonnenschein in the 1995 issue of the "American Journal of Public Health," including a response from the authors.
KW - LETTERS to the editor
KW - AUGMENTATION mammaplasty
N1 - Accession Number: 19893510; Bright, Roselie A. 1 Moore Jr., Roscoe M. 2; Affiliation: 1: Office of Surveillance and Biometrics, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Md 2: Office of International Affairs, US Department of Health and Human Services, Rockville, Md; Source Info: Jun96, Vol. 86 Issue 6, p891; Subject Term: LETTERS to the editor; Subject Term: AUGMENTATION mammaplasty; Number of Pages: 3/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ore, Timothy
AU - Casini, Virgil
T1 - Electrical Fatalities Among U.S. Construction Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/06//
M3 - Article
SP - 587
EP - 592
SN - 00961736
AB - Over 2000 electrocution deaths were identified among U.S. construction workers from 1980 to 1991, with the highest mean annual crude mortality rate (2.5 per 100,000 people), and second highest mean age-adjusted rate (2.7 per 100,000 people) of all industries. Although the crude fatality rates showed a downward trend, construction workers are still about four times more likely to be electrocuted at work than are workers in all industries combined. Nearly 40% of the 5083 fatal electrocutions in all industries combined occurred in construction, and 80% were associated with industrial wiring, appliances, and transmission lines. Electrocutions ranked as the second leading cause of death among construction workers, accounting for an average of 15% of traumatic deaths in the industry from 1980 to 1991. The study indicates that the workers most at risk of electrical injury are male, young, nonwhite, and electricians, structural metal workers, and laborers. The most likely time of injury is 11 a.m. to 3 p.m. from June to August. Focusing prevention on these populations and characteristics through better methods of worker and supervisor electrical safety training, use of adequate protective clothing, and compliance with established procedures could minimize the average annual loss of 168 U.S. construction workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379585; Ore, Timothy 1 Casini, Virgil 1; Affiliation: 1: From the the Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WVa.; Source Info: Jun1996, p587; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3440
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilt, Jeffrey L.
AU - Banks, Daniel E.
AU - Weissman, David N.
AU - Parker, John E.
AU - Vallyathan, Val
AU - Castranova, Vincent
AU - Dedhia, Harakh V.
AU - Stulken, Edward
AU - Ma, Joseph K.H.
AU - Ma, Jane Y.C.
AU - Cruzzaval, Jose
AU - Shumaker, Jennifer
AU - Childress, Charles P.
AU - Lapp, N. LeRoy
T1 - Reduction of Lung Dust Burden in Pneumoconiosis by Whole-Lung Lavage.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/06//
M3 - Article
SP - 619
EP - 624
SN - 00961736
AB - Pneumoconioses are characterized as irreversible, progressive respiratory diseases. No effective therapy exists to prevent progression of these diseases. Whole-lung lavage (WLL) might limit the rate of disease progression through the removal of dust, inflammatory cells, and cytokines. We performed WLL on a 54-year-old underground miner employed as a motorman and roof bolter and a 55-year-old driller at a surface coal mine. Both demonstrated normal lung function and chest radiographs showing ILO profusion category 2 nodular interstitial changes. From Subject 1, we recovered 5.24 x 108 cells (90% macrophages) from the right lung and 3.45 x 108 cells (94% macrophages) from the left lung. WLL removed 1.82 g of mineral dust (non-coal) on the right and 1.64 g on the left. From Subject 2, we recovered 7.49 x 108 cells (46% macrophages) from the right and 9.78 x 108 cells (69% macrophages) from the left lung. WLL removed 0.40 g of mineral dust on the right and 0.53 g on the left. Proinflammatory cytokines, growth factors, and cellular enzymes were also recovered. In cases of pneumoconiosis, WLL is capable of removing relatively large quantities of dust, cells, and soluble materials from the lungs. Only long-term follow-ups of individuals with progressive dust-induced disease who receive WLL therapy in the context of a clinical trial will provide information regarding the importance of removing mineral dust and inflammatory cells from the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379590; Wilt, Jeffrey L. 1 Banks, Daniel E. 1 Weissman, David N. 1 Parker, John E. 1 Vallyathan, Val 1 Castranova, Vincent 1 Dedhia, Harakh V. 1 Stulken, Edward 1 Ma, Joseph K.H. 1 Ma, Jane Y.C. 1 Cruzzaval, Jose 1 Shumaker, Jennifer 1 Childress, Charles P. 1 Lapp, N. LeRoy 1; Affiliation: 1: From the Section of Pulmonary and Critical Care Medicine, Department of Medicine (Dr Wilt, Dr Banks, Dr Weissman, Dr Dedhia, Ms Shumaker, Dr Lapp), the School of Pharmacy (Dr JKH Ma), the Department of Anesthesiology (Dr Dedhia, Dr Stulken), and the Department of Surgery (Dr Cruzzavala), West Virginia University School of Medicine, Morgantown WVa; and the National Institute for Occupational Safety and Health, Morgantown, WVa (Dr Parker, Dr Vallyathan, Dr Castranova, Dr JYC Ma) and Cincinnati, Ohio (Mr Childress).; Source Info: Jun1996, p619; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3980
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DB - aph
ER -
TY - JOUR
AU - Amandus, H. E.
AU - Zahm, D.
AU - Friedmann, R.
AU - Ruback, R. B.
AU - Block, C.
AU - Weiss, J.
AU - Rogan, D.
AU - Holmes, W.
AU - Bynum, T.
AU - Hoffman, D.
AU - McManus, R.
AU - Malcan, J.
AU - Wellford, C.
AU - Kessler, D.
T1 - Employee Injuries and Convenience Store Robberies in Selected Metropolitan Areas.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/07//
M3 - Article
SP - 714
EP - 720
SN - 00961736
AB - The number of robberies and robbery-related injuries to employees in convenience stores (C-stores) during 1992 or 1993 were estimated for selected metropolitan areas around Miami and Tampa, Florida; Atlanta, Georgia; Chicago, Illinois; Baltimore, Maryland; Boston, Massachusetts; Detroit, Michigan; Pittsburgh and Philadelphia, Pennsylvania; Charleston, Columbia, Greenville, and Spartanburg, South Carolina; and Arlington, Chesterfield, and Henrico counties, Virginia. Of the 1835 C-store robberies that occurred during 1992 or 1993 in all selected areas (excluding Atlanta and Chicago), there were 12 homicides of C-store employees; 219 nonfatal injuries of C-store employees; 1071 robberies in which there were no injuries but a weapon was used, displayed, or implied toward a C-store employee; and 132 robberies in which there was no injury and no weapon used, but an employee was struck, pushed, or shoved. Corresponding figures for the 238 robberies that occurred in Chicago during January to June 1993, and for which victim employment status was unknown (customer or employee) were three homicides, 53 nonfatal injuries, 120 attacks in which a weapon was used but there was no injury, and 57 attacks in which a person was struck, pushed, or shoved but there was no injury. The proportion of robberies that resulted in a homicide or injury to an employee varied among selected areas from .03 to .25. The proportion of homicides and injuries to an employee was .14 or higher for target areas in Baltimore (.24), Detroit (.25), and Virginia (.14); the proportion to an employee or customer was .24 in Chicago. The conclusions from these data are that the risk of employee injury in C-store robberies was high in selected metropolitan areas. This underscores the need for effective robbery prevention programs to reduce injury. In addition, further research is needed to determine the effectiveness of present prevention programs in the C-store industry and the application of these programs to other retail industries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379572; Amandus, H. E. 1 Zahm, D. 1 Friedmann, R. 1 Ruback, R. B. 1 Block, C. 1 Weiss, J. 1 Rogan, D. 1 Holmes, W. 1 Bynum, T. 1 Hoffman, D. 1 McManus, R. 1 Malcan, J. 1 Wellford, C. 1 Kessler, D. 1; Affiliation: 1: From the National Institute for Occupational Safety and Health, Morgantown, WVa (Dr Amandus); the Florida Department of Law Enforcement, Tallahassee, Fla (Dr Zahm); the Statistical Analysis Bureau, Department of Criminal Justice, Georgia State University, Atlanta, Ga (Dr Friedman, Dr Ruback); the Illinois Criminal Justice Information Authority, Chicago, Ill (Dr Block); the Department of Criminal Justice, University of Maryland at College Park, College Park, Md (Dr Wellford, Mr Ruback); the Massachusetts Committee on Criminal Justice, Boston, Mass (Dr Holmes); the School of Criminal Justice, Michigan State University, East Lansing, Mich (Dr Bynum); the Pennsylvania Commission on Crime and Delinquency, Harrisburg, Pa (Mr Hoffman); the South Carolina Department of Public Safety, Columbia, SC (Mr McManus); the Virginia Department of Criminal Justice Services, Richmond, Va (Dr Malcan); the Justice Research and Statistics Association, Washington, DC (Ms Weiss); and Silver Spring, Md (Dr Kessler).; Source Info: Jul1996, p714; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4278
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DB - aph
ER -
TY - JOUR
AU - Roberts, Charles DeWitt
T1 - Data Quality of the Drug Abuse Warning Network.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 1996/08//
VL - 22
IS - 3
M3 - Article
SP - 389
EP - 401
SN - 00952990
AB - The purpose of this article was to assess the quality of data collected by the Drug Abuse Warning Network (DAWN), which reports drug abuse emergency department visits. The results of quality assurance studies at 36 sites were reviewed and interpreted. Data collection procedures are not consistent among hospitals and, along with personnel, regularly change within a hospital. Trained investigators reabstracted DAWN report forms at 24 sites and determined that only 57.4% of the cases that met DAWN case definition criteria had been reported; one of five cases had been reported at one site. The technique used in 11 (47.8%) of 23 hospitals to screen for potential DAWN cases detected only 36% of the cases found when all medical charts are examined. The investigators found discrepancies between reported and actual cases in 81.3% of the report forms reabstracted, with an average of 2.3 errors per form. Information as to the drug(s) involved was incorrect in 36.3% of the forms. Due to underreporting of drug abuse emergency department visits and poor quality data in DAWN report forms, DAWN estimates of drug activity must be viewed with caution. Furthermore, estimation of trends is risky, due to differences between emergency departments as to reporting systems and changes over time. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - VICTIMLESS crimes
KW - SUBSTANCE abuse
KW - ALCOHOLISM
KW - DRUG use testing
KW - DRUGGED driving
KW - Alcohol abuse
KW - DAWN
KW - Emergency department
N1 - Accession Number: 9610294244; Roberts, Charles DeWitt 1; Email Address: CROBERTS@SAMHSA.GOV; Affiliation: 1: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Suite 618, Rockwall II, Rockville, Maryland 20857.; Source Info: Aug96, Vol. 22 Issue 3, p389; Subject Term: DRUG abuse; Subject Term: VICTIMLESS crimes; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOLISM; Subject Term: DRUG use testing; Subject Term: DRUGGED driving; Author-Supplied Keyword: Alcohol abuse; Author-Supplied Keyword: DAWN; Author-Supplied Keyword: Emergency department; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoekstra, Edward J.
AU - Kiefer, Max
AU - Tepper, Allison
T1 - Monitoring of Exposure to Benomyl in Nursery Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/08//
M3 - Article
SP - 775
EP - 781
SN - 00961736
AB - We compared urinary levels of the metabolite methyl-5-hydroxy-2-benzimidazole carbamate (5-HBC) among nursery workers exposed to the fungicide benomyl (specifically Benlate 50 DF® [DuPont, Wilmington, DE]) and workers not exposed to benomyl. Environmental exposures were quantitated from gloves, body patches, and air samples collected with area and personal monitors. The median concentration of 5-HBC in the urine of benomyl-exposed workers was 23.8 µmol of 5-HBC per mole of creatinine. No 5-HBC was detected in the reference group. Industrial hygiene results and biological monitoring findings indicate that use of Benlate 50 DF® in the ornamental industry can lead to absorption of the active ingredient, benomyl. Weighing, mixing, and application activities involved the highest exposures. Dermal contact appeared to be the primary route of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379548; Hoekstra, Edward J. 1 Kiefer, Max 1 Tepper, Allison 1; Affiliation: 1: From the Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health (Dr Hoekstra, Mr Kiefer, Dr Tepper), and the Epidemic Intelligence Service (Dr Hoekstra), Centers for Disease Control and Prevention, Cincinnati, Ohio.; Source Info: Aug1996, p775; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4192
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Burnett, Carol A.
AU - Boeniger, Mark F.
AU - Johnson, Jeffrey
T1 - Neurodegenerative Diseases: Occupational Occurrence and Potential Risk Factors, 1982 through 1991.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1996/09//
VL - 86
IS - 9
M3 - Article
SP - 1281
EP - 1288
PB - American Public Health Association
SN - 00900036
AB - Objectives. To identify potential occupational risk factors, this study examined the occupational occurrence of various neurodegenerative diseases. Methods. Death certificates from 27 states in the National Occupational Mortality Surveillance System were evaluated for 1982 to 1991. Proportionate mortality ratios were calculated by occupation for presenile dementia, Alzheimer's disease, Parkinson's disease, and motor neuron disease. Results. Excess mortality was observed for all four categories in the following occupational categories: teachers; medical personnel; machinists and machine operators; scientists; writers/designers/entertainers; and support and clerical workers. Clusters of three neurodegenerative diseases were also found in occupations involving pesticides, solvents, and electromagnetic fields and in legal, library, social, and religious work. Early death from motor neuron disease was found for firefighters, janitors, military personnel, teachers, excavation machine operators, and veterinarians, among others. Conclusions. Neurodegenerative disease occurs more frequently in some occupations than in others, and this distribution, which may indicate occupational risk factors, should be further investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURODEGENERATION
KW - DISEASES -- Risk factors
KW - OCCUPATIONAL diseases
KW - PRESENILE dementia
KW - ALZHEIMER'S disease
KW - PARKINSON'S disease
KW - MOTOR neuron diseases
N1 - Accession Number: 9610020120; Schulte, Paul A. 1 Burnett, Carol A. 2 Boeniger, Mark F. 2 Johnson, Jeffrey 3; Affiliation: 1: Education and Information Division, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 3: Department of Health Policy and Management, Johns Hopkins University, Baltimore, Md.; Source Info: Sep96, Vol. 86 Issue 9, p1281; Subject Term: NEURODEGENERATION; Subject Term: DISEASES -- Risk factors; Subject Term: OCCUPATIONAL diseases; Subject Term: PRESENILE dementia; Subject Term: ALZHEIMER'S disease; Subject Term: PARKINSON'S disease; Subject Term: MOTOR neuron diseases; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 6845
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DB - aph
ER -
TY - JOUR
AU - Godber, Colin
AU - Holmes, Patricia
AU - Pecks, Edward
T1 - The Contribution of the Centre for Mental Health Services Development to Mental Health Services for Older People in the UK.
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
Y1 - 1996/11//
VL - 11
IS - 11
M3 - Article
SP - 1011
EP - 1015
PB - John Wiley & Sons, Inc.
SN - 08856230
AB - The commitment to developing mental health services away from their traditional institutional base into the community is now widespread and old age psychiatry has been prominent in that process. Recognizing the magnitude of the task in many districts, in 1991 the Department of Health for England established the Centre for Mental Health Services Development (CMHSD) as a source of long-term assistance to local managers and professionals responsible for developing increasingly locally based services. CMHSD consultants are from a whole range of backgrounds and are thus readily able to work with the diverse group of people participating in service development.
KW - MENTAL health services
KW - PEOPLE with mental disabilities
KW - MEDICAL care
KW - NURSING care facilities
KW - OLD age assistance
KW - PSYCHIATRY
N1 - Accession Number: 14166264; Godber, Colin 1 Holmes, Patricia 2 Pecks, Edward 3; Affiliation: 1: Consultant in Old Age Psychiatry, Moorgreen Hospital, and Associate Consultnat with the Centre forMental Health Services Development. 2: Associate Consultant withthe Center for Mental Health Services Development. 3: Director of Center for Mental Health Services Development, King's College, London, UK.; Source Info: Nov1996, Vol. 11 Issue 11, p1011; Subject Term: MENTAL health services; Subject Term: PEOPLE with mental disabilities; Subject Term: MEDICAL care; Subject Term: NURSING care facilities; Subject Term: OLD age assistance; Subject Term: PSYCHIATRY; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Malkin, Robert
AU - Kiefer, Max
AU - Tolos, William
T1 - 1-Hydroxypyrene Levels In Coal-Handling Workers at a Coke Oven.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1996/11//
M3 - Article
SP - 1141
EP - 1144
SN - 00961736
AB - An environmental and medical survey was conducted at the coal-handling area of a coke oven, where workers came in contact with coal-tar sludge. The purpose of the study was to determine if skin contact with coal-tar sludge was an important route of exposure to pyrene because workers were observed to have substantial contact with the sludge. Environmental monitoring revealed minimal airborne exposure to pyrene, a byproduct of the coke distillation process; only one personal breathing zone sample detected pyrene, and at a level of 0.001 mg/m3. However, the mean preshift urinary 1-hydroxypyrene concentration was 1.00 µmol/mol creatinine (range, 0.16 to 2.96 µmol/mol creatinine) and the mean postshift level was 1.7 µmol/mol creatinine (range, 0.24 to 4.85 µmol/mol creatinine) (P < 0.01). These levels probably reflect absorption as a result of skin exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379500; Malkin, Robert 1 Kiefer, Max 1 Tolos, William 1; Affiliation: 1: From the Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio (Dr Malkin) and Atlanta, Ga. (Mr Kiefer); and the Division of Biological and Behavioral Sciences, National Institute for Occupational Safety and Health, Cincinnati, Ohio (Mr Tolos).; Source Info: Nov1996, p1141; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2893
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gfroerer, Joseph C.
AU - Greenblatt, Janet C.
AU - Wright, Douglas A.
T1 - Substance Use in the US College-Age Population: Differences According to Educational Status and Living Arrangement.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/01//
VL - 87
IS - 1
M3 - Article
SP - 62
EP - 65
PB - American Public Health Association
SN - 00900036
AB - Objectives. Substance use in the college-age population is an important public health and educational concern. This study compared rates of use among college students and non students, including high school dropouts. from a single data source representative of the nation. Methods. Rates of use were estimated from the combined National Household Surveys on Drug Abuse from 1991 to 1993. Logistic regression models were used to test the effects of educational status and living arrangement. Results. Educational status and living arrangement were found to be. significant predictors of substance use. Rates of illicit drug and cigarette use were highest among high school dropouts, while current and heavy alcohol use were highest among college students. who did not live with their parents. Conclusions. Substantial variation in substance use patterns Within the college-age population suggests that overall rates of use for young adults should not be used to characterize specific subgroups of young adults. These data from a single source will thus help planners more clearly distinguish the service needs of the diverse subgroups within this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - COLLEGE students -- Attitudes
KW - SCHOOL dropouts
KW - DRINKING of alcoholic beverages
KW - YOUNG adults -- Alcohol use
KW - DRUG overdose
KW - REGRESSION analysis
KW - UNITED States
N1 - Accession Number: 9702240098; Gfroerer, Joseph C. 1 Greenblatt, Janet C. 1 Wright, Douglas A. 1; Affiliation: 1: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md.; Source Info: Jan1997, Vol. 87 Issue 1, p62; Subject Term: SUBSTANCE abuse; Subject Term: COLLEGE students -- Attitudes; Subject Term: SCHOOL dropouts; Subject Term: DRINKING of alcoholic beverages; Subject Term: YOUNG adults -- Alcohol use; Subject Term: DRUG overdose; Subject Term: REGRESSION analysis; Subject Term: UNITED States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3417
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Carol W.
T1 - Personal Reflections on Permanency Planning and Cultural Competency.
JO - Journal of Multicultural Social Work
JF - Journal of Multicultural Social Work
Y1 - 1997/01//
VL - 5
IS - 1/2
M3 - Article
SP - 9
EP - 18
SN - 10428224
AB - This article presents the author's personal reflections on permanency planning and cultural competency in child welfare in the U.S. According to the author, achieving permanence and family stability for all children, but particularly children of color, is critical. She reports that an examination of the demographics of child welfare systems reveals that families served are increasingly culturally diverse, and children of color are becoming the majority of children served by these systems. Fifty-two percent of the children in out-of-home care in 1982 were Caucasian. By 1993, that had declined to 38%. At the same time, African American children increased from 34% of the population of children in out-of-home care in 1982 to 46% in 1993. In large urban areas, the great majority of the children in out-of-home care are children of color. The author maintains that to deal effectively with the issue of permanence, a systematic perspective must encompass the ways in which children enter care, the availability of family support and family preservation services, and the need for additional permanency options. This article provides an overview of this perspective and cultural competency in child welfare.
KW - PERMANENCY planning
KW - CHILD welfare
KW - CHILD care
KW - AFRICAN American children
KW - CHILDREN -- United States
KW - UNITED States
N1 - Accession Number: 9710020341; Williams, Carol W. 1; Affiliation: 1: Associate Commissioner, Children's Bureau, Administration on Children, Youth and Families, United States Department of Health and Human Services; Source Info: 1997, Vol. 5 Issue 1/2, p9; Subject Term: PERMANENCY planning; Subject Term: CHILD welfare; Subject Term: CHILD care; Subject Term: AFRICAN American children; Subject Term: CHILDREN -- United States; Subject Term: UNITED States; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HE, XUMING
AU - SHEN, LIJI
T1 - Linear regression after splin transformation.
JO - Biometrika
JF - Biometrika
Y1 - 1997/01/02/
VL - 84
IS - 2
M3 - Article
SP - 474
EP - 481
SN - 00063444
AB - In a transformation model h(Y) = X'β + ε for some smooth and usually monotone function h, we are often interested in the direction of β without knowing the exact form of h. We consider a projection of h onto a linear space of B-spline functions which has the highest correlation with the design variable X. As with the Box-Cox transformation, the transformed response may then be analysed by standard linear regression software. The direction estimate from canonical correlation calculations agrees with the least squares estimate for the approximating model subject to an identifiability constraint This approach is also closely related to the slicing regression of Duan & Li (1991). The dimensionality of the space of spline transformations can be determined by a model selection principle. Typically, a very small number of B-spline knots is needed. A number of real and simulated data examples is presented to demonstrate the usefulness of this approach. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANONICAL transformations
KW - REGRESSION analysis
KW - LEAST squares
KW - SPLINE theory
KW - CORRELATION (Statistics)
KW - B-spline
KW - Box-Cox transformation
KW - Conical analysis
KW - Generalised linear model
KW - Model selsection
KW - Slicing regression
N1 - Accession Number: 80108889; HE, XUMING 1 SHEN, LIJI 2; Affiliation: 1: Department of Statistics, University of Illinois Champaign, Illinois 61820, U.S.A. e-mail: x-he@uiuc.edu 2: Food and Drug Administration USA, HFD-725, 9201 Corporate Boulevard, Rockville, Maryland 20850, U.S.A.; Source Info: 1997, Vol. 84 Issue 2, p474; Subject Term: CANONICAL transformations; Subject Term: REGRESSION analysis; Subject Term: LEAST squares; Subject Term: SPLINE theory; Subject Term: CORRELATION (Statistics); Author-Supplied Keyword: B-spline; Author-Supplied Keyword: Box-Cox transformation; Author-Supplied Keyword: Conical analysis; Author-Supplied Keyword: Generalised linear model; Author-Supplied Keyword: Model selsection; Author-Supplied Keyword: Slicing regression; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SILLIMAN, NANCY PAUL
T1 - Nonparametric classes of weight functions to model publicationbias.
JO - Biometrika
JF - Biometrika
Y1 - 1997/01/04/
VL - 84
IS - 4
M3 - Article
SP - 909
EP - 918
SN - 00063444
AB - This paper addresses the use of weight functions to model publication bias in meta-analysis. Since publication bias is hard to gauge, a nonparametric ε-contamination class of weight functions is introduced. Sensitivity of conclusions to the specification of the weight function is explored by examining the range of results for the entire ε-contamination class. First, lower bounds are found on the coverage of confidence intervals. If little publication bias is suspected, results are robust even when considered over the entire ε-contamination class. However, if more substantial publication bias is suspected, then the coverage provided by the usual interval estimator is not robust. In this case, an alternative interval estimator is suggested. Secondly, for the case in which prior information is available, upper and lower bounds are found on posterior quantities of interest. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLICATION bias
KW - NONPARAMETRIC statistics
KW - META-analysis
KW - CONFIDENCE intervals
KW - ESTIMATION theory
KW - Epsilon-contamination class
KW - Meta-analysis
KW - Selection bias
KW - Weighted distribution
N1 - Accession Number: 80081173; SILLIMAN, NANCY PAUL 1; Affiliation: 1: Division of Biometrics, Center for Drug Evaluation and Research, Food and Drug Administration Rockville, Maryland 20857, U.S.A. e-mail: sillimann@cder.fda.gov; Source Info: 1997, Vol. 84 Issue 4, p909; Subject Term: PUBLICATION bias; Subject Term: NONPARAMETRIC statistics; Subject Term: META-analysis; Subject Term: CONFIDENCE intervals; Subject Term: ESTIMATION theory; Author-Supplied Keyword: Epsilon-contamination class; Author-Supplied Keyword: Meta-analysis; Author-Supplied Keyword: Selection bias; Author-Supplied Keyword: Weighted distribution; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wagner, J. Christopher
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Asbestos-Related Cancer and the Amphibole Hypothesis 1. The First Documentation of the Association.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/04//
VL - 87
IS - 4
M3 - Letter
SP - 687
EP - 688
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor in response to an annotation and a paper about asbestos-related cancer and the amphibole hypothesis and a response by L. T. Stayner, D. A. Dankovic and R. A. Lemen are presented.
KW - LETTERS to the editor
KW - ASBESTOS
KW - CANCER
KW - AMPHIBOLES
KW - HEAT resistant materials
N1 - Accession Number: 20709638; Wagner, J. Christopher 1 Stayner, Leslie T. 2 Dankovic, David A. 2 Lemen, Richard A.; Affiliation: 1: FRCPath, FFOM 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Apr97, Vol. 87 Issue 4, p687; Subject Term: LETTERS to the editor; Subject Term: ASBESTOS; Subject Term: CANCER; Subject Term: AMPHIBOLES; Subject Term: HEAT resistant materials; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Mossman, Brooke T.
AU - Gee, J. Bernard L.
AU - Cullen, Mark R.
AU - Stayner, Leslie T.
AU - Dankovic, David A.
AU - Lemen, Richard A.
T1 - Asbestos-Related Cancer and the Amphibole Hypothesis 4. The Hypothesis Is Still Supported by Scientists and Scientific Data.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/04//
VL - 87
IS - 4
M3 - Letter
SP - 689
EP - 691
PB - American Public Health Association
SN - 00900036
AB - A letter to the editor is presented in response to the article "Annotation: The Amphibole Hypothesis of Asbestos-Related Cancer--Gone But Not Forgotten," by M. R. Cullen in the 1996 issue.
KW - LETTERS to the editor
KW - ASBESTOS
N1 - Accession Number: 20709648; Mossman, Brooke T. 1 Gee, J. Bernard L. 2 Cullen, Mark R. 3 Stayner, Leslie T. 4 Dankovic, David A. 4 Lemen, Richard A.; Affiliation: 1: University of Vermont College of Medicine, Burlington 2: Yale University School of Medicine, New Haven, Conn. 3: School of Medicine, Yale University, New Haven, Conn. 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Apr97, Vol. 87 Issue 4, p689; Subject Term: LETTERS to the editor; Subject Term: ASBESTOS; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grant, Katharyn A.
T1 - Shrawan Kumar and Anil Mital (eds): Electromyography in ergonomics.
JO - Human Factors & Ergonomics in Manufacturing
JF - Human Factors & Ergonomics in Manufacturing
Y1 - 1997///Spring1997
VL - c7
IS - 2
M3 - Book Review
SP - 155
EP - 156
SN - 10908471
AB - Reviews the book "Electromyography in Ergonomics," edited by Shrawan Kumar and Anil Mital.
KW - ELECTROMYOGRAPHY
KW - NONFICTION
KW - KUMAR, Shrawan
KW - MITAL, Anil
KW - ELECTROMYOGRAPHY in Ergonomics (Book)
N1 - Accession Number: 13361239; Grant, Katharyn A. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: Spring1997, Vol. c7 Issue 2, p155; Subject Term: ELECTROMYOGRAPHY; Subject Term: NONFICTION; Reviews & Products: ELECTROMYOGRAPHY in Ergonomics (Book); People: KUMAR, Shrawan; People: MITAL, Anil; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kamerow, Douglas B.
T1 - Before and After Guidelines.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1997/04//
VL - 44
IS - 4
M3 - Editorial
SP - 344
EP - 346
SN - 00943509
AB - The author argues that the health care sector should pay attention to what happens before and after clinical practice guidelines. He cites the various factors that have contributed to the growth of guidelines in the U.S. and these include the increase in health care costs and the variation in the delivery of health care services by region and medical specialty. He mentioned that the U.S. Agency for Health Care Policy and Research has stopped developing guidelines.
KW - PHYSICIAN practice patterns
KW - GUIDELINES
KW - MEDICAL care
KW - MEDICAL care costs
KW - UNITED States
KW - UNITED States. Agency for Health Care Policy & Research
N1 - Accession Number: 9709251698; Kamerow, Douglas B. 1; Affiliation: 1: Agency for Health Care Policy and Research, US Public Health Service, Rockville, Maryland; Source Info: Apr1997, Vol. 44 Issue 4, p344; Subject Term: PHYSICIAN practice patterns; Subject Term: GUIDELINES; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs; Subject Term: UNITED States; Company/Entity: UNITED States. Agency for Health Care Policy & Research; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andrews Jr., John S.
T1 - Public Health Issues in Risk Assessment Related to Environmental Hazards.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/04//
M3 - Article
SP - 366
EP - 366
SN - 00961736
N1 - Accession Number: 113379388; Andrews Jr., John S. 1; Affiliation: 1: Presenting Author: John S. Andrews, Jr., MD, MPH; Associate Administrator for Science; U.S. Public Health Service; Atlanta, GA; Source Info: Apr1997, p366; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 98
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robertson, Leon S.
AU - Maloney, Angela
T1 - Motor Vehicle Rollover and Static Stability: An Exposure Study.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/05//
VL - 87
IS - 5
M3 - Article
SP - 839
EP - 839
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined vehicle rollovers in terms of site-specific exposure and speeds of vehicles of varying stability. Methods. Fifty-one rollover sites in two states were visited at the same time of day and day of week as the rollover. A sample of vehicles moving in the same direction as the rollover were observed, and vehicle-specific data were obtained from identification numbers. Results. Low stability, exacerbated by the addition of passengers, increased the risk of rollover. Speed was not correlated with stability and is not a confounder. Conclusions. Rollovers could be substantially reduced if motor vehicles were manufactured with a static stability of 1.2 or greater. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPORTATION accidents
KW - MOTOR vehicles
KW - HUMAN services
KW - ACCIDENTS
KW - PUBLIC health
N1 - Accession Number: 9707170148; Robertson, Leon S. 1,2 Maloney, Angela 3; Affiliation: 1: Department of Epidemiology and Public Health, Yale University, New Haven, Conn. 2: Nanlee Research, New Haven, Conn. 3: Indian Health Service, Tuba City, Ariz.; Source Info: May97, Vol. 87 Issue 5, p839; Subject Term: TRANSPORTATION accidents; Subject Term: MOTOR vehicles; Subject Term: HUMAN services; Subject Term: ACCIDENTS; Subject Term: PUBLIC health; NAICS/Industry Codes: 415190 Recreational and other motor vehicles merchant wholesalers; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 1852
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie R.
AU - Teh-Wei Hu
T1 - Ethnic differences in mental health services use among the severely mentally ill.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1997/05//
VL - 25
IS - 3
M3 - Article
SP - 235
EP - 247
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - Ethnic differences were examined in patterns of service utilization among 4,000 of the most seriously impaired clients in two county mental health services systems having differing histories of specialized minority-oriented programming. Latino and Asian-American clients in one county and, to a lesser extent African-American clients, made more use than Whites of outpatient and supportive/community services. All three minority groups made less use of inpatient care than Whites. The pattern was reversed in a second county. Results point to the need for greater attention to how mental health service systems are organized to meet special sociocultural needs of ethnic minority clients who have severe mental illness. © 1997 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHNICITY
KW - MENTAL health services
KW - MENTALLY ill
KW - MINORITIES
KW - INPATIENT care
KW - UNITED States
N1 - Accession Number: 11771638; Snowden, Lonnie R. 1 Teh-Wei Hu 1; Affiliation: 1: School of Social Welfare and Center for Mental Health Services Research University of California at Berkeley.; Source Info: May1997, Vol. 25 Issue 3, p235; Subject Term: ETHNICITY; Subject Term: MENTAL health services; Subject Term: MENTALLY ill; Subject Term: MINORITIES; Subject Term: INPATIENT care; Subject Term: UNITED States; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Amandus, H. E.
AU - Hendricks, S. A.
AU - Zahm, D.
AU - Friedmann, R.
AU - Block, C.
AU - Wellford, C.
AU - Brensilber, D.
AU - Bynum, T.
AU - McManus, R.
AU - Malcan, J.
AU - Weiss, J. C.
AU - Kessler, D.
T1 - Convenience Store Robberies in Selected Metropolitan Areas.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/05//
M3 - Article
SP - 442
EP - 447
SN - 00961736
AB - Circumstances of injury were abstracted from police reports for 1835 convenience store robberies that occurred during 1992 or 1993 in selected metropolitan areas of seven eastern states. Subset analyses were performed using the data (758 robberies) from four states with relatively complete risk factor information. The purpose of this study was to estimate the risk of injury in a robbery situation for various risk factors. The overall risk of employee robbery-related injury could not be estimated because the probability of robbery is unknown. Of the 1835 robberies, 59% of the total robberies occurred at nighttime (9 p.m. to 3 a.m.), 47% occurred in stores previously robbed in the study period, 63% involved the use of a firearm, and 12% were associated with an injury to at least one employee. In the subset analysis of 758 robberies in four states, the employee probability of injury in a robbery was lower with firearm use compared with no weapon or use of a blunt instrument, and the probability of severe injury (defined as death, or an injury necessitating a trip to a hospital) was lower with a firearm compared with the use of a blunt instrument. However, all five fatalities were firearm-related. Other factors that were associated with a lower probability of employee injury included robbery occurrence in stores that had been robbed multiple times, compared with stores robbed only once; having 1 to 999 dollars stolen, compared with having no money stolen; and the presence of a customer(s) in the store at the time of the robbery. The employee risk of injury was not significantly different between one- (0.106) and multiple-employee (0.111) stores. Similarly, the employee risk of severe injury was not significantly different between one- (0.029) and multiple-employee stores (0.022). We conclude that there are several potential risk factors for employee injury in convenience store robberies, some of which are amenable to interventions. Further research on these factors and their relationship to employee injury is indicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379298; Amandus, H. E. 1 Hendricks, S. A. 1 Zahm, D. 1 Friedmann, R. 1 Block, C. 1 Wellford, C. 1 Brensilber, D. 1 Bynum, T. 1 McManus, R. 1 Malcan, J. 1 Weiss, J. C. 1 Kessler, D. 1; Affiliation: 1: From the National Institute for Occupational Safety and Health, Morgantown, WVa. (Dr Amandus, Mr Hendricks); Florida Department of Law Enforcement, Tallahassee, Fl. (Dr Zahm); Statistical Analysis Bureau, Department of Criminal Justice, Georgia State University, Atlanta, Ga. (Dr Friedmann); Illinois Criminal Justice Information Authority, Chicago, Ill. (Dr Block); Department of Criminal Justice, University of Maryland at College Park, College Park, Md. (Dr Wellford); Massachusetts Executive Office of Public Safety, Boston, Mass. (Ms Brensilber); School of Criminal Justice, Michigan State University, East Lansing, Mich. (Dr Bynum); South Carolina Department of Public Safety, Columbia, SC (Dr McManus); Virginia Department of Criminal Justice Services, Richmond, Va. (Dr Malcan); Justice Research and Statistics Association, Washington, DC (Ms Weiss); Kent State University, Kent, Ohio (Dr Kessler).; Source Info: May1997, p442; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3672
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pinner, Robert W.
T1 - The larger threat of infectious diseases.
JO - Society
JF - Society
Y1 - 1997/05//May/Jun97
VL - 34
IS - 4
M3 - Article
SP - 42
EP - 43
PB - Springer Science & Business Media B.V.
SN - 01472011
AB - Presents a response to a criticism of an article that reports trends in infectious disease mortality in the U.S. which appeared in a 1996 issue of the "Journal of the American Medical Association." Reason for choosing mortality as the outcome measure of the study; Events that exemplify the volatility of infectious diseases, reinforcing the importance of public health preparedness; Stance regarding the critics' observation that HIV/AIDS and the aging population contributed to these trends.
KW - TRENDS
KW - COMMUNICABLE diseases
KW - MORTALITY
KW - OUTCOME assessment (Medical care)
KW - HIV infections
KW - AIDS (Disease)
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 9706042656; Pinner, Robert W. 1; Affiliation: 1: Special assistant for surveillance, Office of the Director of the National Center for Infectious Diseases, Public Health Service of the Department of Health and Human Services; Source Info: May/Jun97, Vol. 34 Issue 4, p42; Subject Term: TRENDS; Subject Term: COMMUNICABLE diseases; Subject Term: MORTALITY; Subject Term: OUTCOME assessment (Medical care); Subject Term: HIV infections; Subject Term: AIDS (Disease); Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 927
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hamm, Wilfred
T1 - Guide for Effectively Recruiting African American Adoptive Families.
JO - Journal of Multicultural Social Work
JF - Journal of Multicultural Social Work
Y1 - 1997/06//
VL - 5
IS - 3/4
M3 - Article
SP - 139
EP - 149
SN - 10428224
AB - This article details a guide for recruiting African American adoptive families. To attract and retain African American adoptive families, agencies must move beyond their usual audiences and target less traditional adoptive families such as single people, two-parent families in which both parents work, and families that already have children. Consensus is still lacking on what strategies work best in overcoming the obstacles that African American adoptive families and children face in being matched with each other. A national survey of foster parents found that effective recruitment strategies include using current foster parents to recruit new ones, using the media, and recruiting foster parents who wants to work with particular kinds of children. The first step in recruiting adoptive families is to set both the general and specific goal which should be defined by looking at a number and characteristics of African American children who need adoptive placement. An inventory of community resources helps determine what recruitment techniques are practical and maximizes the effectiveness of the campaign. After the campaign, an evaluation should take place to determine whether the objectives were met.
KW - ADOPTIVE parents
KW - AFRICAN Americans
KW - FAMILIES
KW - FOSTER parents
KW - FOSTER home care
KW - UNITED States
N1 - Accession Number: 9708204196; Hamm, Wilfred 1; Affiliation: 1: Chief of Program Operations, Children's Bureau, Administration for Children, Youth and Families, United States Department of Health and Human Services; Source Info: 1997, Vol. 5 Issue 3/4, p139; Subject Term: ADOPTIVE parents; Subject Term: AFRICAN Americans; Subject Term: FAMILIES; Subject Term: FOSTER parents; Subject Term: FOSTER home care; Subject Term: UNITED States; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 623999 All other residential care facilities; NAICS/Industry Codes: 623990 Other Residential Care Facilities; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sakai, Chie
AU - Ollmann, Michael
AU - Kobayashi, Takeshi
AU - Abdel-Malek, Zalfa
AU - Muller, Jacqueline
AU - Vieira, Wilfred D.
AU - Imokawa, Genji
AU - Barsh, Gregory S.
AU - Hearing, Vincent J.
T1 - Modulation of murine melanocyte function in vitro by agouti signal protein.
JO - EMBO Journal
JF - EMBO Journal
Y1 - 1997/06/15/
VL - 16
IS - 12
M3 - Article
SP - 3544
EP - 3552
SN - 02614189
AB - Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two intercellular signaling molecules, α-melanocyte-stimulating hormone (MSH) and agouti signal protein (ASP). In this study, we have characterized the physiological effects of ASP on eumelanogenic melanocytes in culture. Following exposure of black melan-a murine melanocytes to purified recombinant ASP in vitro, pigmentation was markedly inhibited and the production of eumelanosomes was decreased significantly. Melanosomes that were produced became pheomelanosomelike in structure, and chemical analysis showed that eumelanin production was significantly decreased. Melanocytes treated with ASP also exhibited time and dose-dependent decreases in melanogenic gene expression, including those encoding tyrosinase and tyrosinaserelated proteins 1 and 2. Conversely, melanocytes exposed to MSH exhibited an increase in tyrosinase gene expression and function. Simultaneous addition of ASP and MSH at approximately equimolar concentrations produced responses similar to those elicited by the hormone alone. These results demonstrate that eumelanogenic melanocytes can be induced in culture by ASP to exhibit features characteristic of pheomelanogenesis in vivo. Our data are consistent with the hypothesis that the effects of ASP on melanocytes are not mediated solely by inhibition of MSH binding to its receptor, and provide a cell culture model to identify novel factors whose presence is required for pheomelanogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANOCYTES
KW - EPITHELIAL cells
KW - MSH (Hormone)
KW - PEPTIDE hormones
KW - PHENOL oxidase
KW - OXIDASES
KW - MELANOGENESIS
KW - BIOSYNTHESIS
KW - agouti
KW - melanogenesis
KW - pheomelanin
KW - pigmentation
KW - tyrosinase
N1 - Accession Number: 13005533; Sakai, Chie 1 Ollmann, Michael 2 Kobayashi, Takeshi 1,3 Abdel-Malek, Zalfa 4 Muller, Jacqueline 5 Vieira, Wilfred D. 1 Imokawa, Genji 3 Barsh, Gregory S. 2 Hearing, Vincent J. 1; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 2: Department of Pediatrics, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA 3: Kao Institute for Fundamental Research, Haga, Tochigi, Japan 4: Department of Dermatology, University of Cincinnati, Cincinnati, OH 5: Division of Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: 6/15/97, Vol. 16 Issue 12, p3544; Subject Term: MELANOCYTES; Subject Term: EPITHELIAL cells; Subject Term: MSH (Hormone); Subject Term: PEPTIDE hormones; Subject Term: PHENOL oxidase; Subject Term: OXIDASES; Subject Term: MELANOGENESIS; Subject Term: BIOSYNTHESIS; Author-Supplied Keyword: agouti; Author-Supplied Keyword: melanogenesis; Author-Supplied Keyword: pheomelanin; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: tyrosinase; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/emboj/16.12.3544
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hitch, W.L.
AU - Eberhard, M.L.
AU - Lammie, P.J.
T1 - Investigation of the influence of maternal infection with Wuchereria bancrofti on the humoral and cellular responses of neonates to filarial antigens.
JO - Annals of Tropical Medicine & Parasitology
JF - Annals of Tropical Medicine & Parasitology
Y1 - 1997/07//
VL - 91
IS - 5
M3 - Article
SP - 461
PB - Taylor & Francis Ltd
SN - 00034983
AB - Epidemiological data indicate that maternal filarial infection might be associated with increased susceptibility to filarial infection in offspring. To examine the influence of maternal infection on development of antifilarial immunity in neonates, paired cord and maternal sera and mononuclear cells were collected in an area where Wuchereria bancrofti infection is endemic. Anti-filarial humoral responses (IgG, IgM and IgE), non-parasite-specific humoral responses (total IgE), proliferation induced by filarial antigen and production of cytokines (interleukin-2, interleukin-4 and interferon-g) were all monitored. Few cord serum samples had detectable antifilarial IgM or IgE and neither these responses nor total IgE levels differed as a function of maternal infection status. Of cord-blood mononuclear cells assayed, a relatively small proportion exhibited reactivity to filarial antigens. Based on these limited responses to filarial antigens, few neonates display evidence of in-utero sensitization to filarial antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Medicine & Parasitology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FILARIASIS
KW - MATERNAL-fetal exchange
KW - NEWBORN infants -- Diseases
N1 - Accession Number: 7620646; Hitch, W.L. 1 Eberhard, M.L. 2 Lammie, P.J. 2; Email Address: pjll@cdc.gov; Affiliation: 1: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, U.S.A. 2: Division of Parasitic Diseases, National Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30341, U.S.A.; Source Info: Jul1997, Vol. 91 Issue 5, p461; Subject Term: FILARIASIS; Subject Term: MATERNAL-fetal exchange; Subject Term: NEWBORN infants -- Diseases; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/00034989760824
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hutchins, Ellen
T1 - DRUG USE DURING PREGNANCY.
JO - Journal of Drug Issues
JF - Journal of Drug Issues
Y1 - 1997///Summer97
VL - 27
IS - 3
M3 - Article
SP - 463
EP - 485
SN - 00220426
AB - Prevention and intervention services for pregnant, drug-using women have often developed prior to gaining empirical data on the antecedents of prenatal drug use. These data are important to address some of the underlying factors of drug use during pregnancy. A review of the literature indentified at least six categories of psychosocial risk factors that have been investigated as relevant to drug use among women, including pregnant women. These factors include: (1) history of childhood sexual abuse, (2) family history of alcohol or drug problems, (3) male partner's alcohol or drug use, (4) current depression, (5) social support, and (6) homelessness or transiency. An examination of these psychosocial risk factors indicates that the existing literature on these factors in drug use is limited by a lack of methodological rigor, resulting in large variations in prevalence rates due to factors such as definition. This paper summarizes the existing literature and methodological issues regarding the relation between psychosocial risk factors and drug use among women, including pregnant women. It also discusses some of the limitations and issues in assessing prenatal drug use with a particular focus on self-report and urine toxicologies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANT women -- Drug use
KW - PSYCHOSOCIAL factors
KW - CHILD sexual abuse
KW - ALCOHOLISM
KW - SOCIAL support
KW - DRUG abuse
N1 - Accession Number: 9710102078; Hutchins, Ellen 1; Affiliation: 1: Health care administrator, Department of Health and Human Services Maternal and Child Health Bureau, Rockville, Maryland; Source Info: Summer97, Vol. 27 Issue 3, p463; Subject Term: PREGNANT women -- Drug use; Subject Term: PSYCHOSOCIAL factors; Subject Term: CHILD sexual abuse; Subject Term: ALCOHOLISM; Subject Term: SOCIAL support; Subject Term: DRUG abuse; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 23p; Document Type: Article; Full Text Word Count: 10477
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Harold
AU - Schoendorf, Kenneth C.
AU - Gergen, Peter J.
AU - Moore Jr., Roscoe M.
T1 - National trends in mortality of children with sickle cell disease, 1968 through 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/08//
VL - 87
IS - 8
M3 - Article
SP - 1317
EP - 1322
PB - American Public Health Association
SN - 00900036
AB - The article presents a study which describes national trends in mortality of children with sickle cell disease and the settings in which death occurred in the United States. Deaths were included that had any cause coded for sickle cell disease. A preliminary analysis compared the and observed number of deaths from trauma, congenital anomalies, and perinatal conditions, assuming that African American children with sickle cell disease had the same mortality rate from these causes as children without the disease. The analysis suggested that children with sickle cell diseases who died of these causes often did not have sickle cell disease listed on their death certificates. For that reason, and to focus on deaths due to sickle cell disease, researchers excluded deaths having an underlying cause coded as trauma or any cause coded as congenital anomaly or perinatal condition. Since the mid-1960s, young children with sickle cell disease have been known to have an increased risk of severe bacterial diseases, especially those resulting from S. pneumoniae.
KW - SICKLE cell anemia
KW - JUVENILE diseases
KW - DEATH
KW - AFRICAN American children
KW - PERINATOLOGY
KW - BACTERIAL diseases
N1 - Accession Number: 9709302465; Davis, Harold 1 Schoendorf, Kenneth C. 2 Gergen, Peter J. Moore Jr., Roscoe M. 3; Affiliation: 1: Food Drug Administration, Rockville, MD. 2: Infant and Child Health Studies Branch, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md. 3: Office International and Refugee Health, Office of the Secretary, US Department of Health and Human Services, Rockville, MD.; Source Info: Aug1997, Vol. 87 Issue 8, p1317; Subject Term: SICKLE cell anemia; Subject Term: JUVENILE diseases; Subject Term: DEATH; Subject Term: AFRICAN American children; Subject Term: PERINATOLOGY; Subject Term: BACTERIAL diseases; Number of Pages: 6p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article; Full Text Word Count: 4822
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whelan, Elizabeth A.
AU - Piacitelli, Greg M.
AU - Gerwel, Barbara
AU - Schnorr, Teresa M.
AU - Mueller, Charles A.
AU - Gittleman, Janie
AU - Matte, Thomas D.
T1 - Elevated blood lead levels in children of construction workers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/08//
VL - 87
IS - 8
M3 - Article
SP - 1352
EP - 1358
PB - American Public Health Association
SN - 00900036
AB - The article presents a study which examined whether children of lead-exposed construction workers had higher blood lead levels than neighborhood control children. The objective of the current study was to examine an additional population at high risk for pediatric, lead poisoning, the young children of lead-exposed construction workers. Personal interviews were conducted with the adult who had primary responsibility for child care in the household to obtain information about the household. Interviews were also conducted with each worker to obtain specific information about job characteristics and work practices. Venous blood samples were collected from all children. Who had not yet reached their sixth birthday. Samples of dust, loose paint chips, and water at exposed and control homes were collected for determination of lead concentrations. It was found that among exposed families, the child's blood lead levels were significantly correlated with dust lead levels at most sampling locations in the home and automobile, but correlations between child's blood lead and environmental measures were not found for control families.
KW - LEAD in the body
KW - CONSTRUCTION workers
KW - BLOOD analysis
KW - LEAD poisoning in children
KW - CHILD care
KW - JOB descriptions
N1 - Accession Number: 9709302473; Whelan, Elizabeth A. 1,2 Piacitelli, Greg M. 1,2 Gerwel, Barbara 3 Schnorr, Teresa M. 1,2 Mueller, Charles A. 1,2 Gittleman, Janie 1,2 Matte, Thomas D. 4; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health. 2: Centers for Disease Control and Prevention, Cincinnati, Ohio. 3: Occupational Disease and Injury Service, New Jersey State Department of Health and Senior Services, Trenton, NJ. 4: Environmental and Occupational Health Sciences Institute, Piscataway, NJ.; Source Info: Aug1997, Vol. 87 Issue 8, p1352; Subject Term: LEAD in the body; Subject Term: CONSTRUCTION workers; Subject Term: BLOOD analysis; Subject Term: LEAD poisoning in children; Subject Term: CHILD care; Subject Term: JOB descriptions; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 3583
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kisner, Suzanne M.
AU - Pratt, Stephanie G.
T1 - Occupational Fatalities Among Older Workers in the United States: 1980-1991.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/08//
M3 - Article
SP - 1
EP - 1
SN - 00961736
AB - Workers aged 65 and older had a workplace fatality rate 2.6 times that of workers aged 16 to 64 for 1980 through 1991 (14.1 per 100,000 vs 5.4), according to National Traumatic Occupational Fatalities (NTOF) data. The highest rates were in mining, agriculture, and construction. Compared with younger workers, older men were at an elevated risk for fatalities caused by machines, and older women for fatal falls and homicide. Prevention efforts should focus on older workers in agricultural settings, as well as those at increased risk of workplace falls or violence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113635163; Kisner, Suzanne M. 1 Pratt, Stephanie G. 1; Affiliation: 1: Surveillance and Field Investigations Branch, Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, Wva.; Source Info: Aug1997, p1; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 4717
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bolger, Michael
T1 - Commentary: Safety/risk assessment of neurodevelopmental toxins in food.
JO - Mental Retardation & Developmental Disabilities Research Reviews
JF - Mental Retardation & Developmental Disabilities Research Reviews
Y1 - 1997/08//
VL - 3
IS - 3
M3 - Article
SP - 275
EP - 278
PB - John Wiley & Sons, Inc.
SN - 10804013
AB - A number of substances of natural and anthropogenic origin that may exhibit neurodevelopmental potential have been associated with the food supply. In describing the safety assessment process and standards that are used to evaluate the public health significance of these types of substances in food, a clear understanding of the relationship between the requirements of the law and the scientific knowledge required to meet the statutorily mandated safety standards is necessary. The process by which the FDA considers dietary neuroeffective substances is dependent on the statutory mandate under which it operates, namely the federal Food, Drug, and Cosmetic (FD&C) Act of 1958. The FD&C Act specifically mandates 1) the types of food-related substances and associated adverse health effects; 2) the scientific standards of safety/risk; and 3) the assignment of burden of required to achieve compliance with these standards. The categories of food substances vary in their safety/ risk objectives from zero/negligible risk to significant probability of harm. In order to monitor dietary changes, the FDA develops data for estimating changes in dietary exposure of consumers to foodborne substances. The toxicological testing and assessment methodologies utilized to uncover the neurotoxic/developmental properties of food-borne substances can vary considerably. Various regulatory/control procedures are available to maximize public health protection by assuring that the public is either not exposed, or exposure is minimized, to levels that pose negligible risk of neurodevelopmental effects. In exercising its public health and regulatory responsibilities for food-borne substances, the FDA is committed to assessing all relevant toxicological end points, including those substances that have the potential to elicit neurodevelopmental effects. Published 1997 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - FOOD supply
KW - NEUROSCIENCES
KW - PUBLIC health
KW - FOOD law & legislation
KW - FOOD -- Toxicology
KW - additives
KW - assessment
KW - contaminants.
KW - food
KW - neurodevelopmental
KW - safety
N1 - Accession Number: 11781919; Bolger, Michael 1; Affiliation: 1: Contaminants Branch, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, D.C.; Source Info: 1997, Vol. 3 Issue 3, p275; Subject Term: HEALTH risk assessment; Subject Term: FOOD supply; Subject Term: NEUROSCIENCES; Subject Term: PUBLIC health; Subject Term: FOOD law & legislation; Subject Term: FOOD -- Toxicology; Author-Supplied Keyword: additives; Author-Supplied Keyword: assessment; Author-Supplied Keyword: contaminants.; Author-Supplied Keyword: food; Author-Supplied Keyword: neurodevelopmental; Author-Supplied Keyword: safety; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Braddee, Richard W.
AU - Myers, John R.
T1 - Logging-Type Fatalities in the U.S. Production Agriculture Industry, 1980-1992.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 1997/08/09/
VL - 4
IS - 3/4
M3 - Article
SP - 373
EP - 375
SN - 1059924X
AB - Logging activities such as felling trees for firewood and clearing farm land of trees, are conducted by many farmers throughout the country. According to the National Institute for Occupational Safety and Health (NIOSH), National Traumatic Occupational Fatalities (NTOF) surveillance system, these logging-type practices resulted in 173 work-related “struck by falling object” deaths to farmers during the years 1980 through 1992, which represent 46− of all struck-by-falling-object deaths in the agricultural production industry during this 13-year time period. The majority of these deaths occurred in the midwestern (41−) and southern (46−) regions of the United States. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 76040723; Braddee, Richard W. 1 Myers, John R. 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA; Source Info: Aug1997, Vol. 4 Issue 3/4, p373; Number of Pages: 3p; Document Type: Article
L3 - 10.1300/J096v04n03_22
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hassett, Seth
AU - Austin, Michael J.
T1 - Service Integration: Something Old and Something New (Book).
JO - Administration in Social Work
JF - Administration in Social Work
Y1 - 1997/09//
VL - 21
IS - 3/4
M3 - Book Review
SP - 9
EP - 29
SN - 03643107
AB - The authors trace the definition and challenges of "service integration," variously known over time as "collaboration," "coordination," "human services integration," and "one-stop shopping." While the common use of service integration terminology currently may seem to indicate a consensus in favor of a broad systemic reform, motivations and expectations for service integration differ significantly among different players in the service system. The authors conclude that service integration cannot be defined by a particular service model or outcome, but instead should be conceived of as an ongoing reform process. This process, when well-designed and implemented with long-term vision, can reduce duplication, strengthen communities, and improve client outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Administration in Social Work is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN services
KW - SOCIAL integration
KW - SOCIAL change
KW - SHOPPING
N1 - Accession Number: 6766; Hassett, Seth 1 Austin, Michael J. 2; Affiliation: 1: Public Health Analyst, Center for Mental Health Services, Substance Abuse and Mental Health Administration, Washington, DC 2: Professor, School of Social Welfare, University of California at Berkeley, Berkeley, CA 94720; Source Info: 1997, Vol. 21 Issue 3/4, p9; Subject Term: HUMAN services; Subject Term: SOCIAL integration; Subject Term: SOCIAL change; Subject Term: SHOPPING; Number of Pages: 21p; Document Type: Book Review
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ER -
TY - JOUR
AU - Peipins, Lucy A.
AU - Burnett, Carol
AU - Alterman, Toni
AU - Lalich, Nina
T1 - Mortality patterns among female nurses: A 27-state study, 1984 through 1990.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/09//
VL - 87
IS - 9
M3 - Article
SP - 1539
EP - 1543
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the mortality experience of 50 000 nurses using the National Occupational Mortality Surveillance database of death certificates. Methods. Proportionate mortality ratios adjusted by race (White, Black, or other) and 5-year age groups were calculated for selected causes of death among female nurses vs all workers and white-collar workers. Results. Excess deaths among nurses less than 65 years of age were seen in both comparison groups for viral hepatitis, cancer of the nasal cavities, accidental falls, suicide, and drug-related deaths. Among nurses 65 years old or older, deaths due to chronic myeloid leukemia were in excess. Proportionate mortality ratios for breast and colon cancers, diabetes, and heart disease varied by occupational comparison group. Conclusions. These findings confirm results of previous studies and identify new associations. Redoubled efforts are called for in overcoming obstacles to reducing workplace hazards. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - NURSES
KW - DEATH certificates
KW - CHRONIC myeloid leukemia
KW - WOMEN -- Diseases
N1 - Accession Number: 9710250218; Peipins, Lucy A. 1 Burnett, Carol 2 Alterman, Toni 2 Lalich, Nina 2; Affiliation: 1: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Ga. 2: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Sep97, Vol. 87 Issue 9, p1539; Subject Term: MORTALITY; Subject Term: NURSES; Subject Term: DEATH certificates; Subject Term: CHRONIC myeloid leukemia; Subject Term: WOMEN -- Diseases; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3879
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ER -
TY - JOUR
AU - Redd, John T.
AU - Susser, Ezra
T1 - Controlling tuberculosis in an urban emergency department: A rapid decision instrument for patient isolation.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/09//
VL - 87
IS - 9
M3 - Article
SP - 1543
EP - 1547
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined whether data routinely available in emergency departments could be used to improve isolation decisions for tuberculosis patients. Methods. In a large emergency department in New York City, we compared the exposure histories of tuberculosis culture-positive and culture-negative patients and used these data to develop a rapid decision instrument to predict culture-positive tuberculosis. The screen used only data that are routinely available to emergency physicians. Results. The method had high sensitivity (.96) and moderate specificity (.54). Conclusions. The method is easily adaptable for a broad range of settings and illustrates the potential benefits of applying basic epidemiologic methods in a clinical setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOLATION (Hospital care)
KW - TUBERCULOSIS patients
KW - HOSPITAL emergency services
KW - NEW York (N.Y.)
KW - NEW York (State)
N1 - Accession Number: 9710250219; Redd, John T. 1,2 Susser, Ezra 3; Affiliation: 1: Indian Health Service, Department of Medicine, Northern Navajo Medical Center, Shiprock, NM 2: Columbia University College of Physicians and Surgeons, New York 3: Division of Epidemiology and Community Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute/Columbia University New York, NY; Source Info: Sep97, Vol. 87 Issue 9, p1543; Subject Term: ISOLATION (Hospital care); Subject Term: TUBERCULOSIS patients; Subject Term: HOSPITAL emergency services; Subject Term: NEW York (N.Y.); Subject Term: NEW York (State); Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 3690
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DB - aph
ER -
TY - JOUR
AU - Sambrano, Soledad
AU - Jansen, Mary A.
AU - O'Neill, Stephania J.
T1 - Emerging findings from high-risk youth prevention programs.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1997/09//
VL - 25
IS - 5
M3 - Article
SP - 371
EP - 373
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - This article provides information on the success of high-risk youth prevention programs in the U.S. Substance abuse continues to be a major concern in the country. Recent statistics from the National Household Survey on Drug Abuse reveal that progress in combating substance use among youth ages 12 to 17 during the 1980s has stalled or reversed during the 1990s. Negative attitudes toward drug use have declined among adolescents and actual drug use of tobacco and marijuana has increased. Adolescents are inclined to discount the harm that drugs can do. Since 1987, the Substance Abuse and Mental Health Services Administration's Center for Substance Abuse Prevention has funded more than 400 High-Risk Youth demonstration projects targeting youth at risk for substance abuse.
KW - YOUTH -- Substance use
KW - DRUG abuse -- Prevention
KW - SUBSTANCE abuse
KW - HEALTH services administration
KW - YOUTH -- United States
KW - HEALTH planning
KW - UNITED States
N1 - Accession Number: 11771651; Sambrano, Soledad 1 Jansen, Mary A. 1 O'Neill, Stephania J. 1; Affiliation: 1: Center for Substance Abuse Prevention.; Source Info: Sep1997, Vol. 25 Issue 5, p371; Subject Term: YOUTH -- Substance use; Subject Term: DRUG abuse -- Prevention; Subject Term: SUBSTANCE abuse; Subject Term: HEALTH services administration; Subject Term: YOUTH -- United States; Subject Term: HEALTH planning; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Sambrano, Soledad
AU - J. Fred Springer, Soledad
AU - Jack Hermann, Soledad
T1 - Informing the next generation of prevention programs: CSAP's cross-site evaluation of the 1994–95 high-risk youth grantees.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1997/09//
VL - 25
IS - 5
M3 - Article
SP - 375
EP - 395
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - With more than 400 projects funded since its initiation, the Substance Abuse and Mental Health Services Administration's Center for Substance Abuse Prevention (CSAP) High-Risk Youth Demonstration Program (HRY) is a prime example of federally sponsored demonstrations for generating and disseminating policy and program lessons in the area of substance abuse prevention. The HRY demonstration has provided strong support for both local and cross-site evaluation, and incorporated evaluation results into demonstration policy to (a) encourage stronger local evaluation, (b) encourage more coherent program planning and management, (c) encourage use of the risk and resiliency approach(es) to designing programs, and (d) encourage more comprehensive program purposes and activities. In April 1995, the Division of Knowledge Development and Evaluation within CSAP initiated the third cross-site evaluation of HRY programs which utilizes a clear conceptual framework emphasizing the risk and resiliency approach utilized by HRY grantees funded in 1994 and 95. The study implements a common quasi-experimental design across 48 selected sites, and will involve approximately 6,000 treatment and 4,000 comparison subjects. A common questionnaire will be used in all sites, generating data that will support a flexible, regression-based analysis plan. In addition to contributing to the systematic development of substance abuse prevention knowledge, the CSAP National Cross-Site Evaluation of HRY Programs will advance understanding of the design, implementation, and utilization of large, multi-site evaluations as sources of policy learning. © 1997 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Prevention
KW - SUBSTANCE abuse
KW - HEALTH services administration
KW - REGRESSION analysis
KW - HEALTH planning
KW - POLICY sciences
N1 - Accession Number: 11771650; Sambrano, Soledad 1 J. Fred Springer, Soledad 2,3 Jack Hermann, Soledad 4; Affiliation: 1: Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration. 2: EMT Associates, Inc. 3: University of Missouri, St. Louis. 4: Macro International, Inc.; Source Info: Sep1997, Vol. 25 Issue 5, p375; Subject Term: DRUG abuse -- Prevention; Subject Term: SUBSTANCE abuse; Subject Term: HEALTH services administration; Subject Term: REGRESSION analysis; Subject Term: HEALTH planning; Subject Term: POLICY sciences; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 21p; Document Type: Article
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ER -
TY - JOUR
AU - Ore, Timothy
AU - Stout, Nancy A.
T1 - Risk Differences in Fatal Occupational Injuries Among Construction Laborers in the United States, 1980-1992.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/09//
M3 - Article
SP - 832
EP - 843
SN - 00961736
AB - Over 3700 occupational fatalities among all US construction laborers 16 years of age and older during 1980-1992 were analyzed from death certificates to identify differences in mortality rates, higher risk groups, and leading causes of death to be targeted for prevention and monitored over time. Female laborers had an average fatality rate (17.4 deaths/100,000 workers) similar to that for all male construction workers (17.3 deaths/100,000 workers), and ten times higher than for all female construction workers. On average, nonwhite laborers had 27% greater mortality than white laborers. Women were at a higher risk (10.8 deaths/100,000 workers) for motor vehicle injury than were men (6.1 deaths/100,000 workers). The smallest percentage annual decline in cause-specific mortality rates was from motor vehicle for construction laborers (0.1 %) and all construction workers (1.4%). Environmental-related fatality rates for laborers rose an average of 0.8% annually. The average years of potential life lost (to age 65) ranged from 27.4 years from explosion to 34.3 years from electrocution. Prevention measures aimed at addressing the highest risk areas, along with research needs, are discussed. With over a quarter of construction fatalities occurring among laborers, occupational injury research on laborers should become a priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379237; Ore, Timothy 1 Stout, Nancy A. 1; Affiliation: 1: From the Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown WVa.; Source Info: Sep1997, p832; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 6863
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ER -
TY - JOUR
AU - Layne, Larry A.
AU - Landen, Deborah D.
T1 - A Descriptive Analysis of Nonfatal Occupational Injuries to Older Workers, Using a National Probability Sample of Hospital Emergency Departments.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/09//
M3 - Article
SP - 855
EP - 865
SN - 00961736
AB - An estimated 136,985 nonfatal, work-related injuries to workers 55 years of age and older were presented for treatment in hospital emergency departments across the United States during 1993. Men accounted for 63.7% of the injuries and had an injury rate of 1.06 per 100 workers, compared with a rate of 0.76 among women. Among the oldest workers (65+ years), injuries were more likely to be fractures or dislocations, to result from falls on the same level, or to involve hospitalization. The services industry had the largest number of injuries (31.9%), whereas the highest injury rate occurred in the agriculture/forestry/fishing industry (1.50 per 100 workers). The types of injuries most frequently requiring hospitalization were fractures or dislocations that resulted from a fall. Because older workers' employment demographics and injury patterns differ from the remainder of the labor force, interventions need to be developed which are specific to the workplace for this older working population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113379240; Layne, Larry A. 1 Landen, Deborah D. 1; Affiliation: 1: From the Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WVa.; Source Info: Sep1997, p855; Number of Pages: 11p; Document Type: Article; Full Text Word Count: 7524
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DB - aph
ER -
TY - JOUR
AU - Todd, Joan Ferlo
AU - Ruhl, Constance E.
AU - Gross, Thomas P.
T1 - Injury and death associated with hospital bed side-rails: Reports to the US Food and Drug Administration from 1985 to 1995.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/10//
VL - 87
IS - 10
M3 - Article
SP - 1675
EP - 1675
PB - American Public Health Association
SN - 00900036
AB - Objectives. Hospital bed side-rails, while intended for patient protection, can contribute to injury and death. Reports to the Food and Drug Administration (FDA) of hospital bed side-rail entrapment have increased. In this paper entrapment cases are reviewed and the population potentially at risk identified. Methods. FDA's database was searched for events involving hospital beds from January 1985 to August 1995 and entrapment cases were identified. Results. Of 111 entrapments, 65% were associated with death and 23% with injury. Conclusions. Advanced age, female sex, low body weight, and cognitive impairment may be associated with increased risk. Preventive measures are detailed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL beds
KW - HOSPITAL patients
KW - DEATH
KW - WOUNDS & injuries
KW - HOSPITALS -- Furniture, equipment, etc.
KW - HEALTH risk assessment
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 9711170417; Todd, Joan Ferlo 1 Ruhl, Constance E. 1 Gross, Thomas P. 1; Affiliation: 1: Center for Radiological Devices and Health, US Food and Drug Administration, Rockville, Md.; Source Info: Oct97, Vol. 87 Issue 10, p1675; Subject Term: HOSPITAL beds; Subject Term: HOSPITAL patients; Subject Term: DEATH; Subject Term: WOUNDS & injuries; Subject Term: HOSPITALS -- Furniture, equipment, etc.; Subject Term: HEALTH risk assessment; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article; Full Text Word Count: 1540
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DB - aph
ER -
TY - JOUR
AU - Lauermann, Vit
AU - Boeke, Jef D.
T1 - Plus strand strong-stop DNA transfer in yeast Ty retrotransposons.
JO - EMBO Journal
JF - EMBO Journal
Y1 - 1997/11//11/1/97
VL - 16
IS - 21
M3 - Article
SP - 6603
EP - 6612
SN - 02614189
AB - The yeast Ty1 LTR retrotransposon replicates by reverse transcription and integration; the process shows many similarities to the retroviral life cycle. However, we show that plus strand strong-stop DNA transfer in yeast Ty1 elements differs from the analogous retroviral process. By analysis of the native structure of the Ty1 primer binding site and by a series of manipulations of this region and assessment of the effects on retrotransposition, we show that primer binding site inheritance is not from the tRNA primer, which is inconsistent with classical retroviral models. This unusual inheritance pattern holds even when the Ty1 primer binding site is lengthened in order to be more retrovirus-like. Finally, the distantly related Ty3 element has an inheritance pattern like Ty1, indicating evolutionary conservation of the alternative pathway used by Ty1. Based on these results we arrive at a plus strand primer recycling model that explains Ty1 plus strand strong-stop DNA transfer and inheritance patterns in the primer binding site. [ABSTRACT FROM AUTHOR]
AB - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - TRANSPOSONS
KW - MOBILE genetic elements
KW - YEAST
KW - LIFE cycles (Biology)
KW - REVERSE transcriptase
KW - BINDING sites (Biochemistry)
KW - evolution
KW - primer binding site
KW - retrotransposon
KW - reverse transcriptase
KW - trna
KW - yeast
N1 - Accession Number: 13005822; Lauermann, Vit 1 Boeke, Jef D. 2; Affiliation: 1: Laboratory of Retrovirus Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA; Source Info: 11/1/97, Vol. 16 Issue 21, p6603; Subject Term: DNA; Subject Term: TRANSPOSONS; Subject Term: MOBILE genetic elements; Subject Term: YEAST; Subject Term: LIFE cycles (Biology); Subject Term: REVERSE transcriptase; Subject Term: BINDING sites (Biochemistry); Author-Supplied Keyword: evolution; Author-Supplied Keyword: primer binding site; Author-Supplied Keyword: retrotransposon; Author-Supplied Keyword: reverse transcriptase; Author-Supplied Keyword: trna; Author-Supplied Keyword: yeast; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1093/emboj/16.21.6603
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ER -
TY - JOUR
AU - Abrons, Henry L.
AU - Petersen, Martin R.
AU - Sanderson, Wayne T.
AU - Engelberg, Alan L.
AU - Harber, Philip
T1 - Chest Radiography in Portland Cement Workers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/11//
M3 - Article
SP - 1047
EP - 1054
SN - 00961736
AB - To investigate the prevalence of pneumoconiosis in Portland cement workers, a controlled cross-sectional survey was conducted. Chest radiographs of approximately 2640 Portland cement workers showed prevalence rates of about 1 to for rounded and for irregular small opacities and about 2% for pleural abnormalities. After age and smoking adjustment, the overall prevalences were still significantly elevated over controls, but when examined separately by smoking status, the significant increases were confined to smokers. Although statistically significant, the prevalences were only elevated about 1% in cement workers, compared with controls. A statistically significant relationship with exposure was found for pleural abnormalities but not for rounded or irregular small opacities. Thus a weak association exists between pulmonary radiographic abnormalities and employment in US Portland cement plants, and there appears to be a dose-response relationship between exposure and pleural abnormalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 113380066; Abrons, Henry L. 1 Petersen, Martin R. 1 Sanderson, Wayne T. 1 Engelberg, Alan L. 1 Harber, Philip 1; Affiliation: 1: From the National Institute for Occupational Safety and Health, Morgantown, WVa. (Dr Abrons, Dr Petersen, Mr Sanderson, Dr Engelberg); and the University of California at Los Angeles School of Medicine, Los Angeles. Calif. (Dr Harber).; Source Info: Nov1997, p1047; Number of Pages: 8p; Document Type: Article; Full Text Word Count: 5015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Levine, A. Joan
AU - Sieber, Karl
AU - Schulte, Paul
AU - Aziz, Dave
T1 - Incidence of Tuberculosis Infection among New York State Prison Employees.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1997/12//
VL - 87
IS - 12
M3 - Article
SP - 2012
EP - 2014
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined tuberculosis skin test conversions among 24 487 New York State prison employees in 1992. Methods. Conversions were analyzed by prison and by job category. Results. The conversion rate was 1.9%. Employees in prisons with low and high numbers of prisoner cases had odds ratios for conversion of 1.67 (95% confidence interval [CI] = 1.27, 2.19) and 2.20 (95% CI = 1.69, 2.87), respectively, relative to employees in prisons with no prisoner cases. In prisons with cases, guards and medical personnel had odds ratios of 1.64 (95% CI = 1.11, 2.43) and 2.39 (95% CI = 1.40, 4.08), respectively, relative to employees with little prisoner contact. Conclusions. In 1992, approximately one third of new infections among New York State prison employees were due to occupational exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS
KW - PRISONS -- Officials & employees
KW - EPIDEMICS
KW - PUBLIC health
KW - NEW York (State)
N1 - Accession Number: 66038; Steenland, Kyle 1 Levine, A. Joan 2 Sieber, Karl 1 Schulte, Paul 1 Aziz, Dave 3; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: University of Southern California School of Medicine, Los Angeles 3: New York State Department of Correctional Services, Albany; Source Info: Dec1997, Vol. 87 Issue 12, p2012; Subject Term: TUBERCULOSIS; Subject Term: PRISONS -- Officials & employees; Subject Term: EPIDEMICS; Subject Term: PUBLIC health; Subject Term: NEW York (State); NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 1766
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ER -
TY - JOUR
AU - Tubbs, Randy L.
T1 - Medical Surveillance of HAZMAT Response Fire Figthers.
JO - Journal of Occupational Medicine
JF - Journal of Occupational Medicine
Y1 - 1997/12//
M3 - Article
SP - 1135
EP - 1135
SN - 00961736
N1 - Accession Number: 113380038; Tubbs, Randy L. 1; Affiliation: 1: Industrial Hygiene Section, Hazard Evaluation and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH.; Source Info: Dec1997, p1135; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 400
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DB - aph
ER -
TY - JOUR
AU - Bailer, A.
AU - Dankovic, D.
AU - Bailer, A J
AU - Dankovic, D A
T1 - An introduction to the use of physiologically based pharmacokinetic models in risk assessment.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 1997/12//
VL - 6
IS - 4
M3 - journal article
SP - 341
EP - 358
PB - Sage Publications, Ltd.
SN - 09622802
AB - Many extrapolation issues surface in quantitative risk assessments. The extrapolation from high-dose animal studies to low-dose human exposures is of particular concern. Physiologically based pharmacokinetic (PBPK) models are often proposed as tools to mitigate the problems of extrapolation. These models provide a representation of the disposition, metabolism, and excretion of xenobiotics that are believed to possess the potential of inducing adverse human health responses. Given a model of xenobiotic disposition that is applicable for multiple species and appropriate for nonlinearity of the xenobiotic biotransformation process, better extrapolation may be possible. Unfortunately, the true structure of these models (e.g. number of compartments, type of metabolism, etc.) is seldom known, and attributes of these models (tissue volumes, partition coefficients, etc.) are often experimentally determined and often only central measures of these quantities are reported. We describe the use of PBPK models in risk assessment, the structural and parameter uncertainty in these models, and provide a simple illustration of how these characteristics can be incorporated in a statistical analysis of PBPK models. Additional complexity in the analysis of variability in the models is also outlined. This discussion is illustrated using data from methylene chloride. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - RISK assessment
KW - ANIMALS
KW - BIOLOGICAL models
KW - RODENTS
KW - SYSTEM analysis
KW - TUMORS
KW - ENVIRONMENTAL exposure
N1 - Accession Number: 7392788; Bailer, A. 1 Dankovic, D. 2 Bailer, A J 3 Dankovic, D A; Affiliation: 1: Department of Mathematics and Statistics, Miami University, Oxford, Ohio, USA and National Institute for Occupational Safety and Health, United States 2: National Institute for Occupational Safety and Health, Miami University, Oxford, Ohio, USA and National Institute for Occupational Safety and Health, United States 3: Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA; Source Info: 1997, Vol. 6 Issue 4, p341; Subject Term: PHARMACOKINETICS; Subject Term: RISK assessment; Subject Term: ANIMALS; Subject Term: BIOLOGICAL models; Subject Term: RODENTS; Subject Term: SYSTEM analysis; Subject Term: TUMORS; Subject Term: ENVIRONMENTAL exposure; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 18p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hasse, Seth
AU - Austin, Michael J.
T1 - Service Integration.
JO - Administration in Social Work
JF - Administration in Social Work
Y1 - 1997/12/04/
VL - 21
IS - 3/4
M3 - Article
SP - 9
EP - 29
SN - 03643107
AB - The authors trace the definition and challenges of “service integration,” variously known over time as “collaboration,” “coordination,” “human services integration,” and “one-stop shopping.” While the common use of service integration terminology currently may seem to indicate a consensus in favor of a broad systemic reform, motivations and expectations for service integration differ significantly among different players in the service system. The authors conclude that service integration cannot be defined by a particular service model or outcome, but instead should be conceived of as an ongoing reform process. This process, when well-designed and implemented with long-term vision, can reduce duplication, strengthen communities, and improve client outcomes. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Administration in Social Work is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 75934496; Hasse, Seth 1 Austin, Michael J. 2; Affiliation: 1: Center for Mental Health Services, Substance Abuse and Mental Health Administration, Washington, DC, USA 2: School of Social Welfare, University of California at Berkeley, Berkeley, CA, 94720, USA; Source Info: Dec1997, Vol. 21 Issue 3/4, p9; Number of Pages: 21p; Document Type: Article
L3 - 10.1300/J147v21n03_02
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bwire, R.
AU - Slootman, E. J. H.
AU - Verhave, J. P.
AU - Bruins, J.
AU - Docters van Leeuwen, W. M.
T1 - Malaria anticircumsporozoite antibodies in dutch soldiers returning from sub-saharan africa.
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
Y1 - 1998/01//
VL - 3
IS - 1
M3 - Article
SP - 66
EP - 69
PB - Wiley-Blackwell
SN - 13602276
AB - One hundred and twenty-five Dutch servicemen returning from central Africa after a short deployment were enrolled in a study aimed at assessing the effectiveness of malaria prevention measures. None of the persons developed an episode of clinically overt malaria during or after deployment, and no antibodies against blood stages of Plasmodium falciparum could be found. However, antibodies against the circumsporozoite protein (CS) of P. falciparum were demonstrable in 14 persons (11.2% of the study population) by an ELISA test using the recombinant CS-antigen R32tet32, while one person only was positive in an IFA test based on schizonts of P. fieldi as antigen. We concluded that the anti-CS-positive servicemen were probably bitten by mosquitoes carrying P. falciparum parasites while the IFA-positive person was possibly infected by P. vivax , P. ovale or P. malariae parasites. There was no significant association between the different antimalaria preventive measures and the development of anti-CS antibodies. Therefore mefloquine prophylaxis as the single most widely used preventive measure in this group of servicemen was possibly a major contributing factor in averting development of overt malaria.. [ABSTRACT FROM AUTHOR]
AB - Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA -- Prevention
KW - MILITARY personnel
KW - NETHERLANDS
KW - antibodies
KW - circumsporozoite protein
KW - P. falciparum
KW - P. fieldi
KW - P. malariae
KW - P. ovale
KW - P. vivax
N1 - Accession Number: 5089239; Bwire, R. 1 Slootman, E. J. H. 1,2 Verhave, J. P. 3 Bruins, J. 2 Docters van Leeuwen, W. M. 4; Affiliation: 1: Infectious Diseases Control Unit, Occupational Health and Safety Services, Royal Netherlands Army, Utrecht, 2: Office of the Surgeon General, Royal Netherlands Army, The Hague, 3: Department of Parasitology, Academic Hospital St. Radboud, University of Nijmegen, The Netherlands, 4: Department of Epidemiology and Public Health, University of Wageningen, The Netherlands.; Source Info: Jan1998, Vol. 3 Issue 1, p66; Subject Term: MALARIA -- Prevention; Subject Term: MILITARY personnel; Subject Term: NETHERLANDS; Author-Supplied Keyword: antibodies; Author-Supplied Keyword: circumsporozoite protein; Author-Supplied Keyword: P. falciparum; Author-Supplied Keyword: P. fieldi; Author-Supplied Keyword: P. malariae; Author-Supplied Keyword: P. ovale; Author-Supplied Keyword: P. vivax; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1046/j.1365-3156.1998.00165.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenstock, Linda
AU - Olenec, Christopher
AU - Wagner, Gregory R.
T1 - The National Occupational Research Agenda: A Model of Broad Stakeholder Input into Priority Setting.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/03//
VL - 88
IS - 3
M3 - Article
SP - 353
EP - 356
PB - American Public Health Association
SN - 00900036
AB - Objectives. No single organization has the resources necessary to conduct occupational safety and health research to adequately serve the needs of workers in the United Stales. The National Institute for Occupational Safety and Health (NIOSH) undertook the task of setting research priorities in response to a broadly perceived need to systematically address those topics most pressing and most likely to yield gains to workers and to the nation. Methods. NIOSH and its public and private partners used a consensus-building process to set priorities for the next decade for occupational safety and health research the National Occupational Research Agenda. Results. The process resulted in the identification of 21 research priorities grouped into 3 categories: disease and injury, work environment and workforce, and research tools and approaches. Conclusions. Although the field of occupational safety and health is often contentious and adversarial, these research priorities reflect a remarkable degree of concurrence among a broad range of stakeholders who provided input into a clearly defined and open process. (Am J Public Health. 1998;88:353-356) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 453209; Rosenstock, Linda 1 Olenec, Christopher 1 Wagner, Gregory R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Washington, DC; Source Info: Mar98, Vol. 88 Issue 3, p353; Subject Term: INDUSTRIAL hygiene; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article; Full Text Word Count: 2265
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simon, James H. M.
AU - Miller, David L.
AU - Fouchier, Ron A. M.
AU - Soares, Marcelo A.
AU - Peden, Keith W. C.
AU - Malim, Michael H.
T1 - The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: a role for Vif in determining virus host range and cross-species transmission.
JO - EMBO Journal
JF - EMBO Journal
Y1 - 1998/03//3/1/98
VL - 17
IS - 5
M3 - Article
SP - 1259
EP - 1267
SN - 02614189
AB - The primate immunodeficiency virus Vif proteins are essential for replication in appropriate cultured cell systems and, presumably, for the establishment of productive infections in vivo. We describe experiments that define patterns of complementation between human and simian immunodeficiency virus (HIV and SIV) Vif proteins and address the determinants that underlie functional specificity. Using human cells as virus producers, it was found that the HIV-1 Vif protein could modulate the infectivity of HIV-1 itself, HIV-2 and SIV isolated from African green monkeys (SIVAGM). In contrast, the Vif proteins of SIVAGM and SIV isolated from Sykes' monkeys (SIVSYK) were inactive for all HIV and SIV substrates in human cells even though, at least for the SIVAGM protein, robust activity could be demonstrated in cognate African green monkey cells. These observations suggest that species-specific interactions between Vif and virus-producing cells, as opposed to between Vif and virus components, may govern the functional consequences of Vif expression in terms of inducing virion infectivity. The finding that the replication of murine leukemia virus could also be stimulated by HIV-1 Vif expression in human cells further supported this notion. We speculate that species restrictions to Vif function may have contributed to primate immunodeficiency virus zoonosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - VIRUS diseases
KW - VIRAL proteins
KW - MOUSE leukemia viruses
KW - VIRAL replication
KW - CERCOPITHECUS aethiops
KW - hiv
KW - siv
KW - vif
KW - viral infection
KW - zoonosis
N1 - Accession Number: 13006085; Simon, James H. M. 1 Miller, David L. 2 Fouchier, Ron A. M. 2 Soares, Marcelo A. 3 Peden, Keith W. C. 4 Malim, Michael H. 1,2; Email Address: malim@hhmi.upenn.edu; Affiliation: 1: Department of Microbiology and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 2: Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 3: Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: 3/1/98, Vol. 17 Issue 5, p1259; Subject Term: HIV (Viruses); Subject Term: VIRUS diseases; Subject Term: VIRAL proteins; Subject Term: MOUSE leukemia viruses; Subject Term: VIRAL replication; Subject Term: CERCOPITHECUS aethiops; Author-Supplied Keyword: hiv; Author-Supplied Keyword: siv; Author-Supplied Keyword: vif; Author-Supplied Keyword: viral infection; Author-Supplied Keyword: zoonosis; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/emboj/17.5.1259
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosa, Roger R.
AU - Bonnet, Michael H.
AU - Cole, Libby L.
AU - Rosa, R R
AU - Bonnet, M H
AU - Cole, L L
T1 - Work schedule and task factors in upper-extremity fatigue.
JO - Human Factors
JF - Human Factors
Y1 - 1998/03//
VL - 40
IS - 1
M3 - journal article
SP - 150
EP - 158
SN - 00187208
AB - We tested the combined effects of work schedule and task factors on upper-extremity fatigue in the laboratory during 8-h and 12-h shift schedules. Participants performed a simulated manual assembly task at three repetition rates and three torque loads and self-adjusted their work cycle duration to maintain fatigue at moderate levels. Work cycle durations decreased with increases in both load level and repetition rate. Fatigue was observed more quickly with increasing time on shifts and during night shifts compared with day shifts. Work schedule effects were most apparent at lighter workloads, with minimal differences at higher workloads. The highest fatigue levels were observed during 12-h night shifts, with similar levels reached by the end of both the week of 8-h night shifts and the week of 12-h day shifts. Overall durations were 20%-30% shorter than in previous short-term studies, which was likely a result of the more realistic work schedules used in this study. Results from this study could be applied to the design of work-rest schedules for manual tasks involving the upper extremities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORKING hours
KW - FATIGUE
N1 - Accession Number: 549627; Rosa, Roger R. Bonnet, Michael H. Cole, Libby L. Rosa, R R 1 Bonnet, M H Cole, L L; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226, USA; Source Info: Mar1998, Vol. 40 Issue 1, p150; Subject Term: WORKING hours; Subject Term: FATIGUE; Number of Pages: 9p; Illustrations: 1 Chart, 10 Graphs; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Stella M.
T1 - Healthy People 2010.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1998/03//
VL - 2
IS - 1
M3 - Article
SP - 63
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - In the year 2000, the U.S. Department of Health and Human Services will release Healthy People 2010 , the third set of health-promotion and disease-prevention objectives for the nation. One of the focus areas within these objectives is maternal and infant health. This focus area comprises objectives addressing maternal health status and risk factors; infant health status, risk factors, and outcomes; and the use of essential health services by pregnant women, infants, and women of childbearing age. The objectives in this focus area were developed by a multidisciplinary, interagency working group coordinated by the Maternal and Child Health Bureau. The workgroup proposed 39 objectives in 12 clusters. This article presents these objectives and their associated baseline data and targets for the year 2010. Members of the MCH community are encouraged to review and comment on these objectives during the public comment period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - PREGNANT women
KW - INFANT health services
KW - UNITED States
KW - breastfeeding
KW - child health
KW - health policy
KW - infant mortality
KW - low birthweight
KW - Maternal and infant health
KW - prenatal care
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 11307750; Yu, Stella M. 1,2; Email Address: syu@hrsa.dhhs.gov; Affiliation: 1: Maternal and Child Health Bureau, Division of Science, Education and Analysis, Health Resources ans Service Administration, Department of Health and Human Services, Rockville, Maryland 2: Maternal and Child Health Bureau, Division of Science, Education and Analysis, Parklawn Building, Room 18A-55, 5600 Fishers Lane, Rockville, Maryland 20857; Source Info: Mar1998, Vol. 2 Issue 1, p63; Subject Term: HEALTH promotion; Subject Term: PREGNANT women; Subject Term: INFANT health services; Subject Term: UNITED States; Author-Supplied Keyword: breastfeeding; Author-Supplied Keyword: child health; Author-Supplied Keyword: health policy; Author-Supplied Keyword: infant mortality; Author-Supplied Keyword: low birthweight; Author-Supplied Keyword: Maternal and infant health; Author-Supplied Keyword: prenatal care; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Notzon, Francis C.
AU - Komarov, Yuri M.
AU - Ermakov, Sergei P.
AU - Sempos, Christopher T.
AU - Marks, James S.
AU - Sempos, Elena V.
AU - Notzon, F C
AU - Komarov, Y M
AU - Ermakov, S P
AU - Sempos, C T
AU - Marks, J S
AU - Sempos, E V
T1 - Causes of declining life expectancy in Russia.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1998/03/11/
VL - 279
IS - 10
M3 - journal article
SP - 793
EP - 800
SN - 00987484
AB - Context: Russian life expectancy has fallen sharply in the 1990s, but the impact of the major causes of death on that decline has not been measured.Objective: To assess the contribution of selected causes of death to the dramatic decline in life expectancy in Russia in the years following the breakup of the Soviet Union.Design: Mortality and natality data from the vital statistics systems of Russia and the United States.Setting: Russia, 1990-1994.Population: Entire population of Russia.Main Outcome Variables: Mortality rates, life expectancy, and contribution to change in life expectancy.Methods: Application of standard life-table methods to calculate life expectancy by year, and a partitioning method to assess the contribution of specific causes of death and age groups to the overall decline in life expectancy. United States data presented for comparative purposes.Results: Age-adjusted mortality in Russia rose by almost 33% between 1990 and 1994. During that period, life expectancy for Russian men and women declined dramatically from 63.8 and 74.4 years to 57.7 and 71.2 years, respectively, while in the United States, life expectancy increased for both men and women from 71.8 and 78.8 years to 72.4 and 79.0 years, respectively. More than 75% of the decline in life expectancy was due to increased mortality rates for ages 25 to 64 years. Overall, cardiovascular diseases (heart disease and stroke) and injuries accounted for 65% of the decline in life expectancy while infectious diseases, including pneumonia and influenza, accounted for 5.8%, chronic liver diseases and cirrhosis for 2.4%, other alcohol-related causes for 9.6%, and cancer for 0.7%. Increases in cardiovascular mortality accounted for 41.6% of the decline in life expectancy for women and 33.4% for men, while increases in mortality from injuries (eg, falls, occupational injuries, motor vehicle crashes, suicides, and homicides) accounted for 32.8% of the decline in life expectancy for men and 21.8% for women.Conclusion: The striking rise in Russian mortality is beyond the peacetime experience of industrialized countries, with a 5-year decline in life expectancy in 4 years' time. Many factors appear to be operating simultaneously, including economic and social instability, high rates of tobacco and alcohol consumption, poor nutrition, depression, and deterioration of the health care system. Problems in data quality and reporting appear unable to account for these findings. These results clearly demonstrate that major declines in health and life expectancy can take place rapidly. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - LIFE expectancy
KW - RUSSIA -- Social conditions -- 1991-
KW - RUSSIA
N1 - Accession Number: 340591; Notzon, Francis C. Komarov, Yuri M. Ermakov, Sergei P. Sempos, Christopher T. Marks, James S. Sempos, Elena V. Notzon, F C 1 Komarov, Y M Ermakov, S P Sempos, C T Marks, J S Sempos, E V; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, US Department of Health and Human Services, Hyattsville, Md 20782, USA; Source Info: 3/11/98, Vol. 279 Issue 10, p793; Subject Term: PUBLIC health; Subject Term: LIFE expectancy; Subject Term: RUSSIA -- Social conditions -- 1991-; Subject Term: RUSSIA; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 5 Charts, 4 Graphs; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fintor, Lou
AU - Brown, Martin
AU - Fischer, Ruth
AU - Suleiman, Orhan
AU - Garlinghouse, Carol
AU - Camburn, James
AU - Frazier, Emma
AU - Houn, Florence
T1 - The Impact of Mammography Quality Improvement Legislation in Michigan: Implications for the National Mammography Quality Standards Act.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/04//
VL - 88
IS - 4
M3 - Article
SP - 667
EP - 671
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the impact of state legislation on mammography quality and access in Michigan. Methods. The impact of state legislation was analyzed with respect to utilization, numbers of machines and facilities, and image quality. Results. The legislation had a positive effect on image quality improvement, had no impact on utilization by women aged 50 years and above, and resulted in few facility closures. Conclusions. Michigan's legislative intervention appears to have had a positive effect on efforts to improve mammography quality assurance with implications for other federal and state efforts to achieve quality assurance in health care delivery. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMOGRAMS
KW - BREAST exams
KW - BREAST cancer
KW - MEDICAL laws & legislation
KW - MEDICAL care
KW - MICHIGAN
N1 - Accession Number: 1138009; Fintor, Lou Brown, Martin Fischer, Ruth 1 Suleiman, Orhan 1 Garlinghouse, Carol 2 Camburn, James 3 Frazier, Emma Houn, Florence 1; Affiliation: 1: Division of Mammography Quality and Radiation Programs. Food and Drug Administration, Rockville, Md. 2: Center for Health Promotion and Chronic Disease Prevention, Michigan Department of Community Health Lansing 3: Bureau of Health Systems, Michigan Department of Consumer and Industry Services, Lansing; Source Info: Apr98, Vol. 88 Issue 4, p667; Subject Term: MAMMOGRAMS; Subject Term: BREAST exams; Subject Term: BREAST cancer; Subject Term: MEDICAL laws & legislation; Subject Term: MEDICAL care; Subject Term: MICHIGAN; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 2799
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verthelyi, D.
AU - Dybdal, N.
AU - Elias, K.A.
AU - Klinman, D.M.
T1 - DNAse treatment does not improve the survival of lupus prone (NZB×NZW)F[sub 1] mice.
JO - Lupus
JF - Lupus
Y1 - 1998/04//
VL - 7
IS - 4
M3 - Article
SP - 223
EP - 230
PB - Sage Publications Inc.
SN - 09612033
AB - Objective: To examine the efficacy of deoxyribonuclease I (DNAse) therapy in the (NZB× NZW)F[sub 1] murine model of lupus. Methods: Lupus-prone female (NZB×NZW)F[sub 1] mice were treated daily with 0–15 μg/g of recombinant DNAse for 1–6 months. Parameters including anti-DNA autoantibody production, activation of cytokine secreting cells, kidney function and longevity were monitored. Results: DNAse treatment selectively reduced the number of B cells secreting anti-dsDNA antibodies for approximately one month. However, neither short-term nor long-term treatment altered cytokine production, delayed the onset or reduced the severity of glomerulonephritis, or prolonged survival. Conclusion: DNAse treatment initiated before, during, or after the onset of murine lupus did not improve clinical outcome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEOXYRIBONUCLEASES
KW - LUPUS erythematosus -- Treatment
KW - MICE
KW - SYSTEMIC lupus erythematosus
KW - SCIENTIFIC experimentation
KW - (NZB×NZW)F1 mice
KW - Anti-DNA
KW - DNase
KW - Systemic lupus erythematosus
N1 - Accession Number: 5003819; Verthelyi, D. 1 Dybdal, N. 2 Elias, K.A. 3 Klinman, D.M. 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Retroviral Immunology Section, Bethesda, MD 20892 2: Genentech Inc, Pathology Department, South San Francisco, 94080, USA 3: Genentech Inc, Cardiovascular Research, South San Francisco, 94080, USA; Source Info: 1998, Vol. 7 Issue 4, p223; Subject Term: DEOXYRIBONUCLEASES; Subject Term: LUPUS erythematosus -- Treatment; Subject Term: MICE; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: SCIENTIFIC experimentation; Author-Supplied Keyword: (NZB×NZW)F1 mice; Author-Supplied Keyword: Anti-DNA; Author-Supplied Keyword: DNase; Author-Supplied Keyword: Systemic lupus erythematosus; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gaines, A.R.
AU - Varricchio, F.
T1 - Interferon beta-1b injection site reactions and necroses.
JO - Multiple Sclerosis (13524585)
JF - Multiple Sclerosis (13524585)
Y1 - 1998/04//
VL - 4
IS - 2
M3 - Article
SP - 70
EP - 73
PB - Sage Publications, Ltd.
SN - 13524585
AB - We conducted a comprehensive review of selected adverse event reports that were submitted to the Food and Drug Administration (FDA) for interferon beta-1b during the first 30 months following licensure. The adverse events reviewed were injection site reactions, injection site necroses, and non-injection site necroses. These adverse events were selected because of the relative frequency of injection site reactions and because of the severity and sequelae of certain injection site and non-injection site necroses. Our review enabled us to characterize the clinical presentation and the treatment received, which were not described in the package insert or by the IFNB (interferon beta-1b) Multiple Sclerosis Study Group publication. The time of onset of the adverse events ranged from 1 – 29 months after initiation of interferon beta-1b treatment, with a mean of 1 month. In general, the more clinically significant adverse events (i.e., injection site necrosis and non-injection site necrosis) developed more slowly than the injection site reactions. Greater than 85% of the adverse events presented with one or two signs/symptoms, although the number of signs/symptoms ranged from 1 – 8. No predominance of treatments for the adverse events was observed. The most striking finding was that the overall sex ratio, which could be due to reporting artifacts, was 8.1 : 1 female : male. [ABSTRACT FROM AUTHOR]
AB - Copyright of Multiple Sclerosis (13524585) is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - DRUGS -- Side effects
KW - adverse events
KW - beta-1b
KW - interferon
N1 - Accession Number: 5004054; Gaines, A.R. 1 Varricchio, F. 1; Affiliation: 1: Food and Drug Administration, Division of Biostatistics and Epidemiology, Office of Establishment Licensing and Product Surveillance, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Maryland 20852-1448, USA; Source Info: Apr98, Vol. 4 Issue 2, p70; Subject Term: INTERFERONS; Subject Term: DRUGS -- Side effects; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: beta-1b; Author-Supplied Keyword: interferon; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Egeland, Grace M.
AU - Perham-Hester, Katherine A.
AU - Gessner, Bradford D.
AU - Ingle, Diane
AU - Berner, James E.
AU - Middaugh, John P.
T1 - Fetal Alcohol Syndrome in Alaska, 1977 through 1992: An administrative Prevalence Derived from Multiple Data Sources.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/05//
VL - 88
IS - 5
M3 - Article
SP - 781
EP - 786
PB - American Public Health Association
SN - 00900036
AB - Objectives. The prevalence and characteristics of fetal alcohol syndrome cases and the usefulness of various data sources in surveillance were examined in Alaska to guide prevention and future surveillance efforts. Methods. Sixteen data sources in Alaska were used to identify children with fetal alcohol syndrome. Medical charts were reviewed to verify cases, and records were reviewed to provide descriptive data. Results. Fetal alcohol syndrome rates varied markedly by birth year and race, with the highest prevalence (4.1 per 1000 live births) found among Alaska Natives born between 1985 and 1988. Screening and referral programs to diagnostic clinics identified 70% of `all recorded eases. The intervention program for children 0 to 3 years of age detected 29% of age-appropriate cases, and Medicaid data identified 11% of all cases; birth certificates detected only 9% of the age-appropriate cases. Conclusions. Our findings indicate a high prevalence of fetal alcohol syndrome in Alaska and illustrate that reliance on any one data source would lead to underestimates of the extent of fetal alcohol syndrome in a population. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FETAL alcohol syndrome
KW - JUVENILE diseases
KW - MEDICAL screening
KW - MEDICAL referral
KW - ALASKA
N1 - Accession Number: 923636; Egeland, Grace M. 1 Perham-Hester, Katherine A. 2 Gessner, Bradford D. 2 Ingle, Diane 2 Berner, James E. 3 Middaugh, John P. 2; Affiliation: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, and the Division of Public Health, Alaska Department of Health and Social Services, Anchorage. 2: Division of Public Health, Alaska Department of Health and Social Services 3: Indian Health Service, Alaska Area Native Health Service, Anchorage; Source Info: May98, Vol. 88 Issue 5, p781; Subject Term: FETAL alcohol syndrome; Subject Term: JUVENILE diseases; Subject Term: MEDICAL screening; Subject Term: MEDICAL referral; Subject Term: ALASKA; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 5215
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gaston, Marilyn H.
AU - Barrett, Sharon E.
AU - Johnson, Tamara Lewis
AU - Epstein, Leonard G.
T1 - HEALTH CARE NEEDS OF MEDICALLY UNDESERVED WOMEN OF COLOR: The Role of the Bureau of Primary Health Care.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 1998/05//
VL - 23
IS - 2
M3 - Article
SP - 86
EP - 95
PB - Oxford University Press / USA
SN - 03607283
AB - This article focuses on the role of Bureau of Primary Health Care (BPHC), Office of Minority and Women's Health (OMWH), and their legislative mission to enhance the health status of underserved and vulnerable women and their children; to briefly review some of the background data on the medically underserved and the particular status of women of color within that population; to identify a series of questions to help frame the policy dialogue for developing services to medically underserved women of color; and to invite dialogue, feedback, and participation with social workers around a number of these key questions and issues that can help guide our collective vision and health care initiatives for the medically underserved over the next several years. One of the most significant problems for underserved populations is their inability to obtain health care services in the marketplace. The major disparities in health care that pervade the lives of medically underserved women of color, their families, and communities have plagued the United States and all health care professions for decades. Medically underserved women need the human services professions to assist in removing fundamental barriers that restrict their ability to maintain their health, the health of their families, and their communities. Part of that responsibility rests with BPHC and OMWH.
KW - WOMEN -- United States
KW - MEDICAL care
KW - MEDICALLY underserved areas
KW - PUBLIC health
KW - WOMEN of color
KW - UNITED States
KW - accessibility of services
KW - HEALTH AND HUMAN RESOURCES
KW - health care utilization
KW - racial differences women
N1 - Accession Number: 590881; Gaston, Marilyn H. 1,2 Barrett, Sharon E. 3 Johnson, Tamara Lewis 4 Epstein, Leonard G. 5; Affiliation: 1: Associate Administrator, Primary Health Care, Health Resources and Services Administration, Bureau of Primary Health Care (BPHC). 2: Assistant Surgeon General, United States. 3: Associate Director, BPHC, Office of Minority and Women's Health (OMWH). 4: Senior Public Health Analyst, OMWH. 5: Senior Coordinator for Cultural Competency Programs, OMWH.; Source Info: May1998, Vol. 23 Issue 2, p86; Subject Term: WOMEN -- United States; Subject Term: MEDICAL care; Subject Term: MEDICALLY underserved areas; Subject Term: PUBLIC health; Subject Term: WOMEN of color; Subject Term: UNITED States; Author-Supplied Keyword: accessibility of services; Author-Supplied Keyword: HEALTH AND HUMAN RESOURCES; Author-Supplied Keyword: health care utilization; Author-Supplied Keyword: racial differences women; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6908
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gaylor, D.
T1 - Safety assessment with hormetic effects.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 1998/05//
VL - 17
IS - 5
M3 - Article
SP - 251
EP - 253
PB - Sage Publications, Ltd.
SN - 09603271
AB - Discusses the safety of a nonessential chemical. Safety assessment; Disease incidence rates at selected doses for five human subpopulations; Beneficial doses relative to the reference dose for typical hormetic effects.
KW - CHEMICALS
KW - HORMESIS
N1 - Accession Number: 4664258; Gaylor, D. 1; Affiliation: 1: Food and Drug Administration, National Center for Toxicological Research; Source Info: 1998, Vol. 17 Issue 5, p251; Subject Term: CHEMICALS; Subject Term: HORMESIS; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manderscheid, Ronald W.
AU - Manderscheid, R W
T1 - From many into one: addressing the crisis of quality in managed behavioral health care at the millennium.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 1998/05//
VL - 25
IS - 2
M3 - journal article
SP - 233
EP - 237
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - Emphasizes the need to include outcomes other than price into managed mental health care contracts in the United States. Argument that critical resources of care will be eroded from mental health service delivery if price is the sole measure of quality; Need to develop practice guidelines and outcome measures in various sectors of the mental health care industry.
KW - MANAGED mental health care
KW - UNITED States
N1 - Accession Number: 560812; Manderscheid, Ronald W. Manderscheid, R W 1; Affiliation: 1: Survey and Analysis Branch, Center for Mental Health Services, Rockville, MD 20857, USA; Source Info: May98, Vol. 25 Issue 2, p233; Subject Term: MANAGED mental health care; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klutch, Michael
AU - Woerner, Amy M.
AU - Marcus-Sekura, Carol J.
AU - Levin, Judith G.
T1 - Generation of HIV-1/HIV-2 Cross-Reactive Peptide Antisera by Small Sequence Changes in HIV-1 Reverse Transcriptase and Integrase Immunizing Peptides.
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
Y1 - 1998/05//
VL - 5
IS - 3
M3 - Article
SP - 192
EP - 202
PB - BioMed Central
SN - 10217770
AB - We have generated peptide antisera against selected regions in HIV-1 and HIV-2 reverse transcriptase (RT) and integrase (IN) to investigate the specificity of determinants governing the immune response. Peptides representing homologous regions (>50%) in the N- and C-termini and central portions of these proteins were synthesized and injected into rabbits. HIV-1 and HIV-2 IN peptide antisera inhibited IN-mediated cleavage of an HIV-1 DNA oligonucleotide substrate in a 3′ processing assay, while anti-RT or normal sera had no effect. None of the RT sera inhibited RT activity. In Western blots, HIV-2 antisera directed against RT or IN peptides recognized HIV-2 RT and IN proteins, respectively, as expected, but also cross-reacted with the corresponding HIV-1 proteins. By contrast, corresponding HIV-1 antisera were type-specific. In some cases, HIV-1 cross-reactive antisera could be generated by immunization with HIV-1 chimeric peptides with as few as two residues in the HIV-1 sequence changed to the corresponding HIV-2 amino acids. The finding that a type-specific response can be converted to a cross-reactive response suggests alternate strategies for developing new diagnostic reagents which detect HIV-1 and HIV-2. In addition, our results provide a general model for generating HIV peptide vaccines with dual specificity against HIV-1 and HIV-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - PEPTIDES
KW - IMMUNE serums
KW - IMMUNE response
KW - ENZYMES
KW - Chimeric peptides
KW - Cross-reactive response
KW - Enzyme assays
KW - HIV-1
KW - HIV-2
KW - Integrase
KW - Peptide antisera
KW - Peptide diagnostics
KW - Reverse transcriptase
KW - Synthetic peptides
N1 - Accession Number: 11372031; Klutch, Michael 1 Woerner, Amy M. 1 Marcus-Sekura, Carol J. 1 Levin, Judith G. 2; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration 2: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md., USA; Source Info: 1998, Vol. 5 Issue 3, p192; Subject Term: HIV (Viruses); Subject Term: PEPTIDES; Subject Term: IMMUNE serums; Subject Term: IMMUNE response; Subject Term: ENZYMES; Author-Supplied Keyword: Chimeric peptides; Author-Supplied Keyword: Cross-reactive response; Author-Supplied Keyword: Enzyme assays; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: HIV-2; Author-Supplied Keyword: Integrase; Author-Supplied Keyword: Peptide antisera; Author-Supplied Keyword: Peptide diagnostics; Author-Supplied Keyword: Reverse transcriptase; Author-Supplied Keyword: Synthetic peptides; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1159/000025331
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hollingdale, M.R.
AU - McCormick, C.J.
AU - Heal, K.G.
AU - Taylor-Robinson, A.W.
AU - Reeve, P.
AU - Boykins, R.
AU - Kazura, J.W.
T1 - Biology of malarial liver stages: implications for vaccine design.
JO - Annals of Tropical Medicine & Parasitology
JF - Annals of Tropical Medicine & Parasitology
Y1 - 1998/06//
VL - 92
IS - 4
M3 - Article
SP - 411
PB - Taylor & Francis Ltd
SN - 00034983
AB - The molecular events controlling sporozoite invasion and exo-erythrocytic (EE) development within hepatocytes are largely not understood, and EE parasites are probably better defined immunologically than biologically. The observation that the Plasmodium falciparum sporozoite antigen TRAP (thrombospondinrelated anonymous protein) contains multiple adhesive domains that recognize endothelial and hepatocyte receptors indicates that, like leucocyte passage across capillaries, sporozoite invasion probably involves a co-ordinated interaction between sporozoite and hepatic molecules. The parallel with leucocyte extravasation is strengthened by the finding that TRAP contains a functional, integrin-like, I domain. EE parasites are an important target of immunity elicited by irradiated sporozoites, and much current effort is focused on developing malaria vaccines targeting EE parasites. Only one EE-specific antigen, liver-stage antigen 1 (LSA-1), is known to be expressed during EE development and may contribute to protective immunity elicited by irradiated P. falciparum sporozoites. In a study in Papua New Guinea, resistance to P. falciparum infection correlated with CD8+ T-cell interferon-gamma responses to an LSA-1 epitope that contains an HLA A11-restricted sequence. Since A11 is 40% frequent in this population it is reasonable to suggest that, as with B53 responses to LSA-1 in The Gambia, P. falciparum has driven genetic selection of certain HLA haplotypes, as proposed by Haldane nearly 50 years ago. LSA-1 is thus an important vaccine candidate, and is being expressed in bacterial and phage vectors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Medicine & Parasitology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APICOMPLEXA
KW - LIVER cells
KW - MOLECULES
KW - PROTEINS
N1 - Accession Number: 7620671; Hollingdale, M.R. 1; Email Address: m.r.hollingdale@leeds.ac.uk McCormick, C.J. 1 Heal, K.G. 1 Taylor-Robinson, A.W. 1 Reeve, P. 2 Boykins, R. 2 Kazura, J.W. 3; Affiliation: 1: School of Biology, University of Leeds, Leeds LS2 9JT, U.K. 2: Centers for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20853, U.S.A. 3: Division of Geographic Medicine, Case Western Reserve University, Cleveland, OH 44106, U.S.A.; Source Info: Jun1998, Vol. 92 Issue 4, p411; Subject Term: APICOMPLEXA; Subject Term: LIVER cells; Subject Term: MOLECULES; Subject Term: PROTEINS; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/00034989859393
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mouhyi, Jaafar
AU - Sennerby, Lars
AU - Pireaux, Jean-jacques
AU - Dourov, Nicolas
AU - Nammour, Samir
AU - Van Reck, Jack
T1 - An XPS and SEM evaluation of six chemical and physical techniques for cleaning of contaminated titanium implants.
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
Y1 - 1998/06//
VL - 9
IS - 3
M3 - Article
SP - 185
EP - 194
SN - 09057161
AB - The purpose of the present study was to analyse clinically failed and retrieved implants prior to and after cleaning by means of scanning electron microscopy (SEM) and X-ray induced photoelectron spectroscopy (XPS) as compared to unused controls. Six different chemical and physical techniques for cleaning of contaminated titanium implants were evaluated: 1) rinsing in absolute ethanol for 10 min, 2) cleaning in ultrasonic baths containing trichloroethylene (TRI) and absolute ethanol, 10 min in each solution, 3) abrasive cleaning for 30 s, 4) cleaning in supersaturated citric acid for 30 s, 5) cleaning with continuous CO2 laser in dry conditions at 5 W for 10 s, 6) cleaning with continuous CO2 laser in wet conditions (saline) at 5 W for 10 s. SEM of failed implants showed the presence of contaminants of varying sizes and XPS showed almost no titanium but high carbon signals. XPS of unused titanium implants showed lower levels of titanium as previously reported, probably due to contamination of carbon which increased with time in room air. Cleaning of used implants in citric acid followed by rinsing with deionized water for 5 min followed by cleaning in ultrasonic baths with TRI and absolute ethanol gave the best results with regard to macroscopical appearance and surface composition. However, as compared to the unused implants the results from an element composition point of view were still unsatisfactory. It is concluded that further development and testing of techniques for cleaning of organically contaminated titanium is needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Oral Implants Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TITANIUM
KW - SCANNING electron microscopy
KW - X-ray spectroscopy
KW - abrasive air cleaning
KW - citric acid
KW - CO
KW - contamination
KW - titanium implants
KW - ultrasonic cleaning
N1 - Accession Number: 5917985; Mouhyi, Jaafar 1,2 Sennerby, Lars 3,4 Pireaux, Jean-jacques 5 Dourov, Nicolas 6 Nammour, Samir 1,2 Van Reck, Jack 1,2; Affiliation: 1: Department of Oral and Maxillo-Facial Surgery, St Pierre University Hospital, Brussels; 2: School of Medicine, Free University of Brussels; 3: Department of Biomaterials/Handicap Research, Institute for Suraical Sciences, University of Göteborg; 4: Brånemark Clinic, Public-Health Service, City of Göteborg; 5: Dept of Electronic Spectroscopy, Institute for studies in Interface Sciences, Faculte Universitaires Namur, Belgium; 6: Dept of Pathology and Electronmicroscopy, School of Medicine, Brussels; Source Info: Jun1998, Vol. 9 Issue 3, p185; Subject Term: TITANIUM; Subject Term: SCANNING electron microscopy; Subject Term: X-ray spectroscopy; Author-Supplied Keyword: abrasive air cleaning; Author-Supplied Keyword: citric acid; Author-Supplied Keyword: CO; Author-Supplied Keyword: contamination; Author-Supplied Keyword: titanium implants; Author-Supplied Keyword: ultrasonic cleaning; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 10p; Illustrations: 11 Black and White Photographs, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1034/j.1600-0501.1998.090306.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fein, Sara B.
AU - Roe, Brian
T1 - The Effect of Work Status on Initiation and Duration of Breast-Feeding.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/07//
VL - 88
IS - 7
M3 - Article
SP - 1042
EP - 1042
PB - American Public Health Association
SN - 00900036
AB - Objectives. In this study, longitudinal data are used to examine the effect of work status on breast-feeding initiation and duration. Methods. Mothers from a mail panel completed questionnaires during late pregnancy and 10 times in the infant's first year. Mother's work status was categorized for initiation by hours she expected, before delivery, to work and for duration by hours she worked at month 3. Covariates were demographics; parity; medical, delivery, and hospital experiences; social support; embarrassment; and health promotion. Results. Expecting to work part-time neither decreased nor increased the probability of breast-feeding relative to expecting not to work (odds ratios [ORs] = .83 and .89, P > .50), but expecting to work full-time decreased the probability of breast-feeding (OR = .47, P < .01). Working full-time at 3 months postpartum decreased breast-feeding duration by an average of 8.6 weeks (P < .001) relative to not working, but part-time work of 4 or fewer hours per day did not affect duration, and part-time work of more than 4 hours per day decreased duration less than full-time work. Conclusion. Part-time work is an effective strategy to help mothers combine breast-feeding and employment. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREASTFEEDING (Humans)
KW - WORKING mothers
KW - INFANT nutrition
KW - MOTHER & infant
KW - WOMEN employees
N1 - Accession Number: 817316; Fein, Sara B. 1; Email Address: sbf@cfsan.fda.gov Roe, Brian 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC; Source Info: Jul98, Vol. 88 Issue 7, p1042; Subject Term: BREASTFEEDING (Humans); Subject Term: WORKING mothers; Subject Term: INFANT nutrition; Subject Term: MOTHER & infant; Subject Term: WOMEN employees; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 4072
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie R.
AU - Hines, Alice M.
T1 - Acculturation, alcohol consumption, and AIDS-related risky sexual behavior among African American men.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1998/07//
VL - 26
IS - 4
M3 - Article
SP - 345
EP - 359
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - The present study examined the relationship between acculturation, alcohol consumption, and AIDS-related risky sexual behavior in a national probability sample of 338 African American men. Results indicated that acculturation did serve as an indicator of AIDS-related risk: Men at low and moderate levels of acculturation were more likely to engage in risky sexual behavior than were their more highly acculturated counterparts. In addition, interaction effects pointed to groups of high acculturated men—single men and heavy drinkers—who also were likely to engage in risky sexual behavior. Findings from the study suggest that effective AIDS prevention messages should be tailored to high-risk groups within specific cultural and ethnic populations and that risk may differ by level of acculturation. © 1998 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACCULTURATION
KW - DRINKING of alcoholic beverages
KW - MEN -- Sexual behavior
KW - AFRICAN American HIV-positive men
KW - ETHNIC groups
KW - AIDS (Disease)
N1 - Accession Number: 11771685; Snowden, Lonnie R. 1 Hines, Alice M. 2; Affiliation: 1: School of Social Welfare and Center for Mental Health Services Research, University of California at Berkeley 2: College of Social Work, San Jose State University and Alcohol Research Group, Western Consortium for Public Health, Berkeley, California; Source Info: Jul1998, Vol. 26 Issue 4, p345; Subject Term: ACCULTURATION; Subject Term: DRINKING of alcoholic beverages; Subject Term: MEN -- Sexual behavior; Subject Term: AFRICAN American HIV-positive men; Subject Term: ETHNIC groups; Subject Term: AIDS (Disease); NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shields, Peter G.
AU - Ambrosone, Christine B.
T1 - Smoking and Breast Cncer.
JO - Scientific American Presents
JF - Scientific American Presents
Y1 - 1998/07//
M3 - Article
SP - 86
EP - 89
PB - Scientific American
SN - 15240223
AB - The article focuses on the link between smoking and breast cancer. Researchers believe that one important and preventable risk factor for breast cancer is cigarette smoking. New studies suggest that roughly half of all women are particularly sensitive to the carcinogens found in tobacco and so have a higher risk of breast cancer if they smoke cigarettes. Such women have a slow-acting form of a liver enzyme that normally detoxifies carcinogens. Because these women's "detox" enzymes act more slowly than the enzymes of other women, the carcinogens in tobacco last longer in their bodies, allowing the substances more time to cause cancer. INSET: Lung Cancer: Why Women's Risks Are Higher.
KW - BREAST cancer
KW - SMOKING
KW - CIGARETTE smokers
KW - CARCINOGENS
KW - CANCER in women
KW - WOMEN -- Health
N1 - Accession Number: 20921316; Shields, Peter G. 1 Ambrosone, Christine B. 2; Affiliation: 1: Chief of the Molecular Epidemiology Section in the Laboratory of Human Carcinogenesis at the National Cancer Institute 2: Research epidemiologist in the Division of Molecular Epidemiology at the Food and Drug Administration's National Center for Toxicological Research in Jefferson, Ark; Source Info: 1998, p86; Subject Term: BREAST cancer; Subject Term: SMOKING; Subject Term: CIGARETTE smokers; Subject Term: CARCINOGENS; Subject Term: CANCER in women; Subject Term: WOMEN -- Health; Number of Pages: 4p; Illustrations: 1 Color Photograph; Document Type: Article; Full Text Word Count: 2774
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gutman, Steven
AU - Richter, Kimber
AU - Alpert, Susan
AU - Gutman, S
AU - Richter, K
AU - Alpert, S
T1 - Update on FDA regulation of in vitro diagnostic devices.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1998/07/08/
VL - 280
IS - 2
M3 - journal article
SP - 190
EP - 192
SN - 00987484
AB - Provides an update on the United States Food & Drug Administration's (FDA) regulation of in vitro diagnostic devices (IVD). Establishment of the FDA's regulation of diagnostic devices under the Medical Device Amendments of 1976; The goal of device reviews; How IVDs are subject to specific labeling regulations; How the FDA established regulations for good manufacturing practices of diagnostic devices in 1987.
KW - MEDICAL equipment
KW - GOVERNMENT policy
KW - CONSTITUTIONAL amendments
KW - DIAGNOSTIC equipment industry
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 805098; Gutman, Steven Richter, Kimber Alpert, Susan Gutman, S 1 Richter, K Alpert, S; Affiliation: 1: Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20850, USA; Source Info: 7/8/98, Vol. 280 Issue 2, p190; Subject Term: MEDICAL equipment; Subject Term: GOVERNMENT policy; Subject Term: CONSTITUTIONAL amendments; Subject Term: DIAGNOSTIC equipment industry; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 3p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Headrick, Marci L.
AU - Korangy, Shahin
AU - Bean, Nancy H.
AU - Angulo, Frederick J.
AU - Altekruse, Sean F.
AU - Potter, Morris E.
AU - Klontz, Karl C.
T1 - The Epidemiology of Raw Milk--Associated Foodborne Disease Outbreaks Reported in the United States, 1973 Through 1992.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/08//
VL - 88
IS - 8
M3 - Article
SP - 1219
EP - 1221
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study describes the epidemiology of raw milk-associated outbreaks reported to the Centers for Disease Control and Prevention from 1973 through 1992. Methods. Surveillance data for each reported raw milk-associated outbreak were reviewed. A national survey was conducted to determine the legal status of intrastate raw milk sales for the period 1973 through 1995. Results. Forty-six raw milk-associated outbreaks were reported during the study period; 40 outbreaks (87%) occurred in states where the intrastate sale of raw milk was legal. Conclusions. Consumption of raw milk remains a preventable cause of foodborne disease outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAW milk
KW - MILK
KW - COMMUNICABLE diseases -- Transmission
KW - EPIDEMIOLOGY
KW - FOODBORNE diseases
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 936471; Headrick, Marci L. 1 Korangy, Shahin 1 Bean, Nancy H. 2 Angulo, Frederick J. 2 Altekruse, Sean F. 3 Potter, Morris E. 2 Klontz, Karl C. 1; Affiliation: 1: Epidemiology Branch, Center for Food Safety and Applied Nutrition, Washington, DC 2: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Atlanta, Ga 3: Food and Drug Administration liaison to the National Center for Infectious Diseases; Source Info: Aug1998, Vol. 88 Issue 8, p1219; Subject Term: RAW milk; Subject Term: MILK; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: EPIDEMIOLOGY; Subject Term: FOODBORNE diseases; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 3p; Illustrations: 1 Chart, 1 Map; Document Type: Article; Full Text Word Count: 1869
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turturro, A.
AU - Hass, B.
AU - Hart, R.W.
T1 - Hormesis – Implications for risk assessment caloric intake (body weight) as an exemplar.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 1998/08//
VL - 17
IS - 8
M3 - Article
SP - 454
EP - 459
PB - Sage Publications, Ltd.
SN - 09603271
AB - Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter into risk assessments for toxicants. Based on the work with caloric intake, one could: (a) define a biomarker for hormetic effect; (b) integrate specific information on when in the animals lifespan the parameter is active to influence parameters such as survival; (c) evaluate component effects of the overall hormetic response; and (d) address the consequences of a non-monotonic relationship between the hormetic parameter and endpoints critical for risk assessment. These impacts on risk assessments have been characterized for chronic tests, but are also true for short-term tests. A priority is the characterization of the dose-response curves for hormetic parameters. This quantification will be critical in utilizing them in risk assessment. With this information, one could better quantitatively address the changes one expects to result from the hormetic parameter, and limit the uncertainty and variability which occurs in toxicity testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HORMESIS
KW - RISK assessment
KW - NUTRITION
KW - HEALTH
KW - bioassay
KW - body weight
KW - caloric intake
KW - dietary control
KW - hormesis
KW - Non-monotonic
N1 - Accession Number: 4664061; Turturro, A. 1 Hass, B. 2 Hart, R.W. 3; Affiliation: 1: National Center for Toxicological Research, Division of Biometry and Risk Assessment, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA 2: National Center for Toxicological Research, Division of Genetic Toxicology, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA 3: National Center for Toxicological Research, Office of the Director, 3900 N.C.T.R. Road, Jefferson, Arkansas 72079, USA; Source Info: 1998, Vol. 17 Issue 8, p454; Subject Term: HORMESIS; Subject Term: RISK assessment; Subject Term: NUTRITION; Subject Term: HEALTH; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: body weight; Author-Supplied Keyword: caloric intake; Author-Supplied Keyword: dietary control; Author-Supplied Keyword: hormesis; Author-Supplied Keyword: Non-monotonic; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rith-Najarian, Stephen
AU - Branchaud, Charmaine
AU - Beaulieu, Oran
AU - Gohdes, Dorothy
AU - Simonson, Gregg
AU - Mazze, Roger
T1 - Reducing Lower-Extremity Amputations Due to Diabetes.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1998/08//
VL - 47
IS - 2
M3 - Article
SP - 127
EP - 132
SN - 00943509
AB - BACKGROUND. While Lower-extremity amputation (LEA) is a frequent complication of diabetes, effective strategies for the prevention of LEA in primary care settings have not been extensively studied. METHODS. This prospective study of American Indians with diabetes in a rural primary care clinic was divided into three periods: the standard care period (1986 to 1989), during which patients received foot care at the discretion of the primary care provider; the public health period (1990 to 1993), during which patients were screened for foot problems and high-risk individuals received foot care education and protective footwear; and the Staged Diabetes Management (SDM) period (1994 to 1996), during which comprehensive guidelines for diabetic foot management were adapted by the primary care clinicians to their practices and were systematically implemented. RESULTS. A total of 639 individuals contributed 4322 diabetic person-years during the three periods of observation. Patient sex distribution, mean age, and mean duration of diabetes were similar in the three periods. The average annual LEA incidence was 29/1000 diabetic person-years for the standard care period (n=42), 21/1000 for the public health period (n=33), and 15/1000 for the SDM period (n=20), an overall 48% reduction (P = .016). Overall, the incidence of a first amputation declined from 21/1000 to 6/1000 (P < .001). CONCLUSIONS. The customization and systematic implementation of practice guidelines by local primary care providers was associated with improved diabetic foot care outcomes. SDM has relevance to primary care organizations seeking to improve outcomes for patients with diabetes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPUTATION
KW - DIABETES -- Complications
KW - PRIMARY care (Medicine)
KW - NATIVE Americans
KW - SEX distribution (Demography)
KW - MEDICAL care
KW - amputation
KW - Diabetes
KW - Indians
KW - Indians, North American
KW - lower extremity
KW - North American
KW - primary care
N1 - Accession Number: 996875; Rith-Najarian, Stephen 1; Email Address: srithnajarian@nchs.com Branchaud, Charmaine 2 Beaulieu, Oran Gohdes, Dorothy 3 Simonson, Gregg 4 Mazze, Roger 4; Affiliation: 1: Bemidji Area Indian Health Service Diabetes Program, Bemidji, Minnesota 2: Redlake Indian Health Service Hospital, Red Lake Minnesota 3: Indian Health Service, Headquarters West, Albuquerque, New Mexico 4: International Diabetes Center, Minneapolis, Minnesota; Source Info: Aug1998, Vol. 47 Issue 2, p127; Subject Term: AMPUTATION; Subject Term: DIABETES -- Complications; Subject Term: PRIMARY care (Medicine); Subject Term: NATIVE Americans; Subject Term: SEX distribution (Demography); Subject Term: MEDICAL care; Author-Supplied Keyword: amputation; Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: Indians; Author-Supplied Keyword: Indians, North American; Author-Supplied Keyword: lower extremity; Author-Supplied Keyword: North American; Author-Supplied Keyword: primary care; Number of Pages: 6p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tisdale, Julie A.
AU - Sofge, Christine W.
T1 - Women and Work: Highlights of NIOSH Research.
JO - Journal of Women's Health
JF - Journal of Women's Health
Y1 - 1998/08//
VL - 7
IS - 6
M3 - Article
SP - 651
PB - Mary Ann Liebert, Inc.
SN - 10597115
AB - The article focuses on the works of the National Institute for Occupational Safety and Health (NIOSH) in the U.S. NIOSH is a part of the Centers for Disease Control and Prevention, and is the federal agency responsible for conducting research and making recommendations for the prevention of work-related disease and injury. NIOSH is mandated by Congress to "assure safe and healthful working conditions for working men and women." It is important to understand and appreciate the connection between human health and workplace hazards. Although often overlooked, the workplace can have a profound impact on a worker's health, ranging from cancer in factory workers to carpal tunnel syndrome in computer users. Although NIOSH research and prevention efforts protect all workers, the Institute recognizes that women often face unique risks such as chemical and physical exposures that affect pregnancy or the menstrual cycle or hazards encountered using equipment designed for male workers of larger stature. In addition to protecting workingwomen, studying workers can improve the health of the general population.
KW - INDUSTRIAL safety
KW - INDUSTRIAL hygiene
KW - WORK environment
KW - EMPLOYEE health promotion
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 5878879; Tisdale, Julie A. 1 Sofge, Christine W.; Affiliation: 1: National Institute for Occupational Safety and Health 200 Independence Avenue, SW, 715-H Washington, DC 20201.; Source Info: Aug98, Vol. 7 Issue 6, p651; Subject Term: INDUSTRIAL safety; Subject Term: INDUSTRIAL hygiene; Subject Term: WORK environment; Subject Term: EMPLOYEE health promotion; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Honig, P.K.
AU - Gillespie, B.K.
T1 - Clinical Significance of Pharmacokinetic Drug Interactions with Over-the-Counter (OTC) Drugs.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 1998/09//
VL - 35
IS - 3
M3 - Article
SP - 167
EP - 171
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Focuses on the clinical significance of pharmacokinetic drug interactions with over-the-counter (OTC) drugs. Antacids; Histamine receptor antagonists; Factors influencing self-medication decisions; Populations at-risk for prescription-over-the-counter drug interactions.
KW - DRUG interactions
KW - NONPRESCRIPTION drugs
KW - SELF medication
KW - Antacids, drug-interactions
KW - Antiasthmatics, drug-interactions
KW - Antibacterials, drug-interactions
KW - Anticoagulants, drug-interactions
KW - Benzodiazepines, drug-interactions
KW - Drug-interactions
KW - H2-antagonists, drug-interactions
KW - Nonsteroidal-antiinflammatories, drug-interactions
KW - OTC-drugs
KW - Reviews-on-treatment
KW - Theophylline, drug-interactions
KW - Warfarin, drug-interactions
N1 - Accession Number: 9523237; Honig, P.K. 1 Gillespie, B.K. 2; Affiliation: 1: Department of Medicine, Georgetown University, Washington, DC, USA 2: Office of Clinical Pharmacology and Biopharmaceutics, US Food and Drug Administration, Rockville, Maryland, USA; Source Info: 1998, Vol. 35 Issue 3, p167; Subject Term: DRUG interactions; Subject Term: NONPRESCRIPTION drugs; Subject Term: SELF medication; Author-Supplied Keyword: Antacids, drug-interactions; Author-Supplied Keyword: Antiasthmatics, drug-interactions; Author-Supplied Keyword: Antibacterials, drug-interactions; Author-Supplied Keyword: Anticoagulants, drug-interactions; Author-Supplied Keyword: Benzodiazepines, drug-interactions; Author-Supplied Keyword: Drug-interactions; Author-Supplied Keyword: H2-antagonists, drug-interactions; Author-Supplied Keyword: Nonsteroidal-antiinflammatories, drug-interactions; Author-Supplied Keyword: OTC-drugs; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Theophylline, drug-interactions; Author-Supplied Keyword: Warfarin, drug-interactions; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie R.
T1 - Racial differences in informal help seeking for mental health problems.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1998/09//
VL - 26
IS - 5
M3 - Article
SP - 429
EP - 438
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - The present study examined the hypothesis of greater African American informal help seeking for mental health problems in a comparison of African Americans and Whites. Controlling for sociodemographic factors, symptom distress, and diagnosis, African Americans were less likely than Whites to report turning for assistance to a friend, family member, or religious figure. Nor did African Americans use informal help as a substitute for professional care; they turned to informal helpers in conjunction with formal helpers, and demonstrated complementarity to a greater extent than Whites. Supportive ties found among African Americans may be advantageous for many purposes, but provide no benefit for the face-to-face discussion of emotional problems. © 1998 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RACE discrimination
KW - MENTAL illness
KW - AFRICAN Americans
KW - HELP-seeking behavior
KW - RACISM
KW - MENTAL health
N1 - Accession Number: 11771693; Snowden, Lonnie R. 1; Affiliation: 1: School of Social Welfare Center for Mental Health Services Research University of California at Berkeley.; Source Info: Sep1998, Vol. 26 Issue 5, p429; Subject Term: RACE discrimination; Subject Term: MENTAL illness; Subject Term: AFRICAN Americans; Subject Term: HELP-seeking behavior; Subject Term: RACISM; Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vanyushin, Boris F.
AU - Lopatina, Nadezhda G.
AU - Wise, Carolyn K.
AU - Fullerton, Floyd R.
AU - Poirier, Lionel A.
T1 - Butylated hydroxytoluene modulates DNA methylation in rats.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 1998/09/15/Sep98 Part 2
VL - 256
IS - 3
M3 - Article
SP - 518
EP - 527
PB - Wiley-Blackwell
SN - 00142956
AB - The major observation of this investigation is that a single intraperitoneal injection of butylated hydroxytoluene (BHT, 60 mg/kg body mass) results within a few hours in a strong increase in nuclear DNA(cytosine-5)-methyl transferase (methyl transferase) activity in the liver, kidneys, heart, spleen, brain and lungs of male rats. In most organs, the rise in methyl transferase activity is observed as early as 4 h after BHT injection, it reaches a maximum at 8 h and then, except for lungs and brain, gradually decreases to its initial level at 16 h. At the maximum induction times, the methyl transferase activity in liver, kidney and spleen increases by about 16-, 3- and 5-fold, respectively. A second BHT injection at 96 h results in a secondary rise in hepatic methyl transferase activity. Isoelectric focusing electrophoresis of control rat liver nuclear extracts showed methyl transferase activity in the pI 4.7 and 7.4 protein fractions. Both fractions methylate calf thymus DNA better than they do Drosophila melanogaster DNA. In similar extracts from BHT-treated rats, the methyl transferase activity is found in three protein fractions with pI values equal to 4.0, 6.2 and 9.5, respectively. Most of the methyl transferase fractions from the livers of BHT-treated rats methylate the completely unmethylated D. melanogaster DNA better than they do calf thymus DNA. Thus, BHT induces methyl transferase activity that preferably provides de novo DNA methylation. BHT injection had no significant effect on the hepatic contents of S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy) and AdoMet/AdoHcy ratios. While BHT injection did not alter the 5-methyldeoxycytidine content in liver DNA, it did appear to alter such content in other organs. BHT appears to cause the reversible changes in the methylation status of an internal cytosine residue in some CCGG sites of the rat liver cytosine DNA-methyl transferase gene. BHT induces also hypomethylation of the renal methyl... [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - CELL differentiation
KW - MESSENGER RNA
KW - METHYLATION
KW - 5-methyldeoxycytidine.
KW - Butylated hydroxytoluene
KW - cancer
KW - DNA methyl transferase
KW - DNA methylation
N1 - Accession Number: 5276956; Vanyushin, Boris F. 1 Lopatina, Nadezhda G. 2 Wise, Carolyn K. 2 Fullerton, Floyd R. 2 Poirier, Lionel A. 2; Affiliation: 1: Division of Molecular Basis of Ontogenesis, A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia 2: National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Sep98 Part 2, Vol. 256 Issue 3, p518; Subject Term: DNA; Subject Term: CELL differentiation; Subject Term: MESSENGER RNA; Subject Term: METHYLATION; Author-Supplied Keyword: 5-methyldeoxycytidine.; Author-Supplied Keyword: Butylated hydroxytoluene; Author-Supplied Keyword: cancer; Author-Supplied Keyword: DNA methyl transferase; Author-Supplied Keyword: DNA methylation; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 2 Charts, 10 Graphs; Document Type: Article
L3 - 10.1046/j.1432-1327.1998.2560518.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kasiske, Bertram L
AU - Rith-Najarian, Stephen
AU - Casper, Michele L
AU - Croft, Janet B
T1 - American Indian heritage and risk factors for renal injury.
JO - Kidney International
JF - Kidney International
Y1 - 1998/10//
VL - 54
IS - 4
M3 - Article
SP - 1305
EP - 1310
SN - 00852538
AB - American Indian heritage and risk factors for renal injury. Background. Little is known about the causes and consequences of renal disease among American Indians in the Great Lakes region of the United States. Methods . We examined clinical correlates of albumin/creatinine ratios among 1368 participants in the three tribal communities of the Inter-Tribal Heart Project using univariate and multivariate analysis. Results . Compared to 1086 participants without albuminuria, the 240 with microalbuminuria (30 to 299 mg/g) and the 42 with macroalbuminuria (>300 mg/g) were more likely to report a history of a myocardial infarction (6.4%, 16.0%, and 23.8%, respectively, P < 0.001). Similarly, compared to patients without albuminuria, those with microalbuminuria and macroalbuminuria were more likely to report a history of stroke (2.3%, 8.4% and 26.2%, respectively, P < 0.001). In a multiple linear regression model, independent correlates of albumin excretion (P < 0.05) included: fasting blood sugar, treated diabetes, treated hypertension, higher systolic blood pressure, lower diastolic blood pressure, abnormal electrocardiogram, a history of stroke, the degree of American Indian heritage, and lower household income. Conclusions . Urinary albumin excretion is associated with cardiovascular disease outcomes and risk factors among American Indians of the Great Lakes region. Both heredity and socioeconomic status appear to play a role in the pathogenesis of renal injury in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBUMINURIA
KW - INDIGENOUS peoples of the Americas
KW - DISEASES
KW - KIDNEYS -- Wounds & injuries
KW - RISK factors
KW - UNITED States
KW - albuminuria
KW - American Indian heritage
KW - cardiovascular disease
KW - diabetes
KW - Great Lakes population
KW - hypertension
KW - Inter-Tribal Heart Project
KW - myocardial infarction
KW - socioeconomic status & health
N1 - Accession Number: 5881737; Kasiske, Bertram L 1,2 Rith-Najarian, Stephen 1,2 Casper, Michele L 1,2 Croft, Janet B 1,2; Affiliation: 1: Division of Nephrology, Department of Medicine Hennepin County Medical Center, Minneapolis, and Diabetes Program, Bemidji Area Office, Indian Health Service, Bemidji, Minnesota, 2: Cardiovascular Health Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; Source Info: Oct1998, Vol. 54 Issue 4, p1305; Subject Term: ALBUMINURIA; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: DISEASES; Subject Term: KIDNEYS -- Wounds & injuries; Subject Term: RISK factors; Subject Term: UNITED States; Author-Supplied Keyword: albuminuria; Author-Supplied Keyword: American Indian heritage; Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: Great Lakes population; Author-Supplied Keyword: hypertension; Author-Supplied Keyword: Inter-Tribal Heart Project; Author-Supplied Keyword: myocardial infarction; Author-Supplied Keyword: socioeconomic status & health; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1046/j.1523-1755.1998.00106.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenheck, Robert
AU - Morrisey, Joseph
AU - Lam, Julie
AU - Calloway, Michael
AU - Johnsen, Matthew
AU - Goldman, Howard
AU - Randolph, Frances
AU - Blasinsky, Margaret
AU - Fontana, Alan
AU - Calsyn, Robert
AU - Teague, Gregory
T1 - Service System Integration, Access to Services, and Housing Outcomes in a Program for Homeless Persons With Severe Mental Illness.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/11//
VL - 88
IS - 11
M3 - Article
SP - 1610
EP - 1615
PB - American Public Health Association
SN - 00900036
AB - Objectives. This Study evaluated the hypothesis that greater integration and coordination between agencies within services systems is associated with greater accessibility of services and improved client housing outcomes. Methods. As part of the Access to Community Care and Effective Services and Support program, data were obtained on baseline client characteristics, services use, and 3-months and 12-month outcomes from 1832 clients seen at 18 sites during the first year of program operation. Data on interorganizational relationships were obtained from structured interviews with key informants from relevant organizations in each community (n=32-82 at each site). Results. Complete follow-up data were obtained from 1340 clients (73%). After control for baseline characteristics, service system integration was associated with superior housing outcomes at 12 months, and this relationship was mediated through greater access to housing agencies. Conclusions. Service system integration is related to improved access to housing services and better housing outcomes among homeless people with mental illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMELESS persons
KW - HOMELESSNESS
KW - MENTALLY ill -- Housing
KW - MENTALLY ill -- Services for
KW - HEALTH services accessibility
KW - HEALTH care networks
N1 - Accession Number: 1259590; Rosenheck, Robert 1; Email Address: robert.rosenheck@yale.edu Morrisey, Joseph 2 Lam, Julie 1 Calloway, Michael 2 Johnsen, Matthew 3 Goldman, Howard 4 Randolph, Frances 5 Blasinsky, Margaret 3 Fontana, Alan 1 Calsyn, Robert 6 Teague, Gregory 7; Affiliation: 1: Department of Veterans Affairs Northeast Program Evaluation Center and Yale Department of Psychiatry, West Haven, Conn. 2: Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill. 3: ROW Sciences Inc., Rockville, Md. 4: Department of Psychiatry, University of Maryland School of Medicine, Baltimore. 5: Homeless Programs Branch, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, Md. 6: Department of Psychology, University of Missouri, St. Louis. 7: Florida Mental Health Institute, University of South Florida, Tampa.; Source Info: Nov98, Vol. 88 Issue 11, p1610; Subject Term: HOMELESS persons; Subject Term: HOMELESSNESS; Subject Term: MENTALLY ill -- Housing; Subject Term: MENTALLY ill -- Services for; Subject Term: HEALTH services accessibility; Subject Term: HEALTH care networks; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 5171
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, A. J.
AU - Eblen, B. S.
AU - Oser, A.
AU - Burkhardt, W.
T1 - Application and evaluation of male-specific bacteriophage as a process integrity or faecal contamination indicator in a pork slaughterhouse environment.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 1998/11//
VL - 85
IS - 5
M3 - Article
SP - 898
EP - 904
PB - Wiley-Blackwell
SN - 13645072
AB - A male-specific bacteriophage plaque assay was evaluated as a faecal contamination or process integrity indicator for aspects of the pork slaughter process. Over 400 samples were tested including: sponge swabs from animal hauling trailer floors and dressed carcass surfaces; faecal material; water from slaughter sites; and water from each stage of wastewater treatment. Bacteriophage were observed in wastewater, trailers, slaughter process water and swine faeces. No bacteriophage were observed on dressed carcasses. Numbers of phage plaque-forming units per gram or millilitre showed greater variation and were usually lower than standard indicators, including total coliform or Escherichia coli counts. Among the applications studied, male-specific bacteriophage appear to be best suited for process control verification for wastewater treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIOPHAGES
KW - MICROBIAL contamination
KW - SLAUGHTERING & slaughterhouses
N1 - Accession Number: 5277778; Miller, A. J. 1 Eblen, B. S. 1 Oser, A. 2 Burkhardt, W. 3; Affiliation: 1: Microbial Food Safety Research Unit, Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA, 2: Hatfield Meats, Inc., Hatfield, PA, and 3: U.S. Public Health Service, U.S. Food & Drug Administration, AL, USA; Source Info: Nov98, Vol. 85 Issue 5, p898; Subject Term: BACTERIOPHAGES; Subject Term: MICROBIAL contamination; Subject Term: SLAUGHTERING & slaughterhouses; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Geoffrey M.
AU - Mueller, Charles A.
AU - Fajen, John M.
AU - Chrislip, David W.
AU - Russo, John
AU - Briggle, Thomas
AU - Fleming, Lora E.
AU - Suruda, Anthony J.
AU - Steenland, Kyle
T1 - Health Effects Associated With Sulfuryl Fluoride and Methyl Bromide Exposure Among Structural Fumigation Workers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1998/12//
VL - 88
IS - 12
M3 - Article
SP - 1774
EP - 1780
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study assessed the health effects associated with occupational exposure to methyl bromide and sulfuryl fluoride among structural fumigation workers. Methods. A cross-sectional study of 123 structural fumigation workers and 120 referents in south Florida was conducted. Nerve conduction, vibration, neuro behavioral, visual, olfactory, and renal function testing was included. Results. The median lifetime duration of methyl bromide and sulfuryl fluoride exposure among workers was 1.20 years and 2.85 years, respectively. Sulfuryl fluoride exposure over the year preceding examination was associated with significantly reduced performance on the Pattern Memory Test and on olfactory testing. In addition, fumigation workers had significantly reduced performance on the Santa Ana Dexterity Test of the dominant hand and a nonsignificantly higher prevalence of carpal tunnel syndrome than did the referents. Conclusions. Occupational sulfuryl fluoride exposures may be associated with subclinical effects on the central nervous system, including effects on olfactory and some cognitive functions. However, no widespread pattern of cognitive deficits was observed. The peripheral nerve effects were likely caused by ergonomic stresses experienced by the fumigation workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BROMOMETHANE
KW - FUMIGATION
KW - CARPAL tunnel syndrome
KW - ENTRAPMENT neuropathies
KW - SMELL disorders
KW - COGNITIVE ability
N1 - Accession Number: 1354707; Calvert, Geoffrey M. 1; Email Address: jac6@cdc.gov Mueller, Charles A. 1 Fajen, John M. 1 Chrislip, David W. 2 Russo, John 2 Briggle, Thomas 3 Fleming, Lora E. 3 Suruda, Anthony J. 4 Steenland, Kyle 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. 2: Division of Behavioral and Biomedical Sciences, National Institute for Occupational Safety and Health, Cincinnati, Ohio. 3: Department of Epiemiology and Public Health, University of Miami School of Medicine, Miami, Fla. 4: Rocky Mountain Center for Occupational and Environmental Health, University of Utah, Salt Lake City.; Source Info: Dec1998, Vol. 88 Issue 12, p1774; Subject Term: BROMOMETHANE; Subject Term: FUMIGATION; Subject Term: CARPAL tunnel syndrome; Subject Term: ENTRAPMENT neuropathies; Subject Term: SMELL disorders; Subject Term: COGNITIVE ability; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 6553
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pargament, Kenneth I.
AU - Smith, Bruce W.
AU - Koenig, Harold G.
AU - Perez, Lisa
T1 - Patterns of Positive and Negative Religious Coping with Major Life Stressors.
JO - Journal for the Scientific Study of Religion
JF - Journal for the Scientific Study of Religion
Y1 - 1998/12//
VL - 37
IS - 4
M3 - Article
SP - 710
EP - 724
PB - Wiley-Blackwell
SN - 00218294
AB - This study attempted to identify positive and negative patterns of religious coping methods, develop a brief measure of these religious coping patterns, and examine their implications for health and adjustment. Through exploratory and confirmatory factor analyses, positive and negative religious coping patterns were identified in samples of people coping with the Oklahoma City bombing, college students coping with major life stressors, and elderly hospitalized patients coping with serious medical illnesses. A 14-item measure of positive and negative patterns of religious coping methods (Brief RCOPE) was constructed. The positive pattern consisted of religious forgiveness, seeking spiritual support, collaborative religious coping, spiritual connection, religious purification, and benevolent religious reappraisal. The negative pattern was defined by spiritual discontent, punishing God reappraisals, interpersonal religious discontent, demonic reappraisal, and reappraisal of God's powers. As predicted, people made more use of the positive than the negative religious coping methods. Furthermore, the two patterns had different implications for health and adjustment. The Brief RCOPE offers an efficient, theoretically meaningful way to integrate religious dimensions into models and studies of stress, coping, and health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal for the Scientific Study of Religion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RELIGIOUS behaviors
KW - RELIGION
KW - ADJUSTMENT (Psychology)
KW - FACTOR analysis
N1 - Accession Number: 1525389; Pargament, Kenneth I. 1; Email Address: kpargam@bgnet.bgsu.edu Smith, Bruce W. 2 Koenig, Harold G. 3 Perez, Lisa 4; Affiliation: 1: Professor of Psychology, Department of Psychology, Bowling Green State University, Bowling Green, OH 43403 2: Minister and graduate student, clinical psychology, Arizona State University, Tempe, AZ 85287 3: Associate professor of psychiatry and behavioral sciences, Department of Psychiatry, P.O. Box 3400, Duke University Medical Center, Durham, NC 27710 4: National Research Council Fellow, National Institute for Occupational Safety and Health, Robert Taft Laboratories, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226; Source Info: Dec98, Vol. 37 Issue 4, p710; Subject Term: RELIGIOUS behaviors; Subject Term: RELIGION; Subject Term: ADJUSTMENT (Psychology); Subject Term: FACTOR analysis; Number of Pages: 15p; Illustrations: 6 Charts; Document Type: Article; Full Text Word Count: 8070
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spisak, Shelly
AU - Holt, Katrina
AU - Mayer, Rochelle
AU - Rossetti, John
T1 - Improving Children's Access to Oral Health Services: The Oral Health Initiative.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1998/12//
VL - 2
IS - 4
M3 - Article
SP - 261
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Although major improvements have been made in oral health during the 20th century, many children in minority groups, from families with low-income, and with special health care needs still do not receive the oral health services that they need. To address the problem, the Health Resources and Services Administration (HRSA), working with the Health Care Financing Administration (HCFA), has launched the Oral Health Initiative. The initiative seeks to strengthen oral health service-delivery systems, enhance collaboration among federal agencies, and provide states with the resources needed to improve the oral health of hard-to-reach children. HRSA's activities include enhancing programs, services, and training, such as expanding the number of direct-service dental programs; establishing or enhancing graduate training programs in pediatric and general dentistry and in dental public health; and funding training programs in dentistry to train dental public health leaders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD health services
KW - ORAL medicine
KW - CHILDREN -- Health
KW - UNITED States
KW - access to care
KW - dental disease
KW - Health Resources and Services Administration
KW - managed care
KW - Medicaid, Children's Health Insurance Program (CHIP)
KW - National Maternal and Child Oral Health Resource Center
KW - oral health
KW - Oral Health Initiative
N1 - Accession Number: 11307774; Spisak, Shelly 1 Holt, Katrina 1 Mayer, Rochelle 1 Rossetti, John 2; Affiliation: 1: National Center for Education in Maternal and Child Health, Georgetown University, Washington, DC 2: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD; Source Info: Dec1998, Vol. 2 Issue 4, p261; Subject Term: CHILD health services; Subject Term: ORAL medicine; Subject Term: CHILDREN -- Health; Subject Term: UNITED States; Author-Supplied Keyword: access to care; Author-Supplied Keyword: dental disease; Author-Supplied Keyword: Health Resources and Services Administration; Author-Supplied Keyword: managed care; Author-Supplied Keyword: Medicaid, Children's Health Insurance Program (CHIP); Author-Supplied Keyword: National Maternal and Child Oral Health Resource Center; Author-Supplied Keyword: oral health; Author-Supplied Keyword: Oral Health Initiative; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rickards, Lawrence D.
AU - Leginski, Walter
AU - Randolph, Frances L.
AU - Oakley, Deirdre
AU - Herrell, James M.
AU - Gallagher, Cheryl
T1 - Cooperative Agreements for CMHS/CSAT Collaborative Program to Prevent Homelessness: An Overview.
JO - Alcoholism Treatment Quarterly
JF - Alcoholism Treatment Quarterly
Y1 - 1999/01//
VL - 17
IS - 1/2
M3 - Article
SP - 1
EP - 15
SN - 07347324
AB - Although there has been a considerable investment in housing, treatment, and support services over the past decade, homelessness continues to be a risk for individuals with serious mental illnesses and particularly those with co-occurring alcohol and other drug disorders. In 1996, the Center for Mental Health Services and the Center for Substance Abuse Treatment launched a two-phased, three-year initiative to document and evaluate the effectiveness of homelessness prevention interventions that focus on persons with psychiatric and/or substance use disorders who are formerly homeless or at-risk for homelessness, and who are engaged with the mental health and/or substance abuse treatment system(s). This article describes the background, logic model, goals, and structure of the CMHS/CSAT Collaborative Program to Prevent Homelessness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Alcoholism Treatment Quarterly is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMELESSNESS
KW - MENTALLY ill
KW - DUAL diagnosis
KW - MENTAL health services
KW - SUBSTANCE abuse -- Treatment
KW - cooperative agreements
KW - Dual diagnosis
KW - logic models
KW - program manual
N1 - Accession Number: 2370829; Rickards, Lawrence D. 1 Leginski, Walter 1 Randolph, Frances L. 1 Oakley, Deirdre 2 Herrell, James M. 3 Gallagher, Cheryl 4; Affiliation: 1: Homeless Programs Branch, Center for Mental Health Services, 5600 Fishers Lane, Room 11C-05, Rockville, MD 20857 2: Technical Assistance Coordinator, National Resource Center on Homelessness and Mental Illness, Policy Research Associates, Inc., Delmar, NY 3: Division of Practice and Systems Development at CSAT 4: Organization of Services Branch, Division of Practice and Systems Development, both at the Center for Substance Abuse Treatment, Rockville, MD; Source Info: 1999, Vol. 17 Issue 1/2, p1; Subject Term: HOMELESSNESS; Subject Term: MENTALLY ill; Subject Term: DUAL diagnosis; Subject Term: MENTAL health services; Subject Term: SUBSTANCE abuse -- Treatment; Author-Supplied Keyword: cooperative agreements; Author-Supplied Keyword: Dual diagnosis; Author-Supplied Keyword: logic models; Author-Supplied Keyword: program manual; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 15p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hanrahan, Patricia
AU - Oakley, Deirdre
AU - Rickards, Lawrence D.
AU - Luchins, Daniel J.
AU - Herrell, James M.
AU - Conrad, Kendon J.
AU - Matters, Michael D.
AU - Gallagher, Cheryl
T1 - Cross-Site Issues in the Collaborative Program to Prevent Homelessness: Conclusion.
JO - Alcoholism Treatment Quarterly
JF - Alcoholism Treatment Quarterly
Y1 - 1999/01//
VL - 17
IS - 1/2
M3 - Article
SP - 187
EP - 208
SN - 07347324
AB - This article explores similarities and contrasts between projects and describes activities being conducted conjointly. The Collaborative Program to Prevent Homelessness (CPPH) logic model incorporates features of the logic model described for the Homeless Programs Branch (HPB) and the logic models presented by each of the homelessness prevention program project sites. And although the identified populations are dissimilar from one another, they are all within the scope of the HPB and CPPH logic models. For example, Community Connections identifies poor service coordination and system fragmentation as systems level problems that lead to service attrition, attenuated treatment gains and housing instability. All of the homelessness prevention projects serve some persons with substance abuse problems; however, two projects are designed to serve only persons with substance problems; Arapahoe House and the Center for Therapeutic Community Research. A high proportion of racial and ethnic minorities are served by these programs with African-Americans being the majority in the four projects. The provision of a range of housing alternatives is central to most of the interventions, although the type of housing available varies across projects.
KW - EMERGENCY housing
KW - HOMELESS shelters
KW - MATHEMATICAL models
KW - HUMAN services
KW - MINORITIES
N1 - Accession Number: 2370839; Hanrahan, Patricia 1 Oakley, Deirdre 2 Rickards, Lawrence D. 3 Luchins, Daniel J. 4 Herrell, James M. 5 Conrad, Kendon J. 6 Matters, Michael D. 7 Gallagher, Cheryl 8; Affiliation: 1: Associate Professor, Department of Psychiatry, University of Chicago 2: Research Associate II/Prevention Policy Coordinator, Policy Research Associates, Inc. 3: Project Officer, Homeless Programs Branch, Center for Mental Health Services, JAMHSA 4: Associate Director for Clinical Services, Illinois Department of Human Services 5: Division of Practice and Systems Development at CSAT 6: Professor, School of Public Health, University of Illinois at Chicago 7: Research Assistant Professor, School of Public Health, University of Illinois at Chicago 8: Project Officer, Division of Practice and Systems Development, Center for Substance Abuse Treatment, SAMHSA; Source Info: 1999, Vol. 17 Issue 1/2, p187; Subject Term: EMERGENCY housing; Subject Term: HOMELESS shelters; Subject Term: MATHEMATICAL models; Subject Term: HUMAN services; Subject Term: MINORITIES; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624220 Community housing services; NAICS/Industry Codes: 624221 Temporary Shelters; Number of Pages: 22p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mahmood, I.
AU - Balian, J.D.
T1 - The Pharmacokinetic Principles Behind Scaling from Preclinical Results to Phase I Protocols.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 1999/01//
VL - 36
IS - 1
M3 - Article
SP - 1
EP - 11
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Extrapolation of animal data to assess pharmacokinetic parameters in humans is an important tool in drug development. Allometric scaling has many proponents, and many different approaches and techniques have been proposed to optimise the prediction of pharmacokinetic parameters from animals to humans. The allometric approach is based on the power function Y = aW, where the bodyweight of the species is plotted against the pharmacokinetic parameter of interest on a log-log scale. Clearance, volume of distribution and elimination half-life are the 3 most frequently extrapolated pharmacokinetic parameters. Clearance is not predicted very well (error between predicted and observed clearance >30%) using the basic allometric equation in most cases. Thus, several other approaches have been proposed. An early approach was the concept of neoteny, where the clearance is predicted on the basis of species bodyweight and maximum life-span potential. A second approach uses a 2-term power equation based on brain and bodyweight to predict the intrinsic clearance of drugs that are primarily eliminated by phase I oxidative metabolism. Most recently, the use of the product of brain weight and clearance has been proposed. A literature review reveals different degrees of success of improved prediction with the different methods for various drugs. In a comparative study, the determining factor in selecting a method for prediction of clearance was found to be the value of the exponent. Integration of in vitro data into in vivo clearance to improve the predictive performance of clearance has also been suggested. Although there are proponents of using body surface area instead of bodyweight, no advantage has been noted in this approach. It has also been noted that the unbound clearance of a drug cannot be predicted any better than the total body clearance (CL). In general, there is a good correlation between bodyweight and volume of the central compartment (V); hence, V does not face the same complications as CL. The relationship between elimination half-life (t) and bodyweight across species results in poor correlation, most probably because of the hybrid nature of this parameter. When a reasonable prediction of CL and V is made, t may be predicted from the equation t = 0.693V/CL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL models in research
KW - DRUG development
KW - PHARMACOKINETICS
KW - Bioavailability
KW - Clinical-trial-design
KW - Comparative-pharmacokinetics
N1 - Accession Number: 9523177; Mahmood, I. 1 Balian, J.D. 1; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Division of Pharmaceutical Evaluation I, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 1999, Vol. 36 Issue 1, p1; Subject Term: ANIMAL models in research; Subject Term: DRUG development; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: Bioavailability; Author-Supplied Keyword: Clinical-trial-design; Author-Supplied Keyword: Comparative-pharmacokinetics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lamb Jr, LS
AU - Gee, AP
AU - Hazlett, LJ
AU - Musk, P
AU - Parrish, RS
AU - O'Hanlon, TP
AU - Geier, SS
AU - Folk, RS
AU - Harris, WG
AU - McPherson, K
AU - Lee, C
AU - Henslee-Downey, PJ
T1 - Influence of T Cell Depletion Method on Circulating γδ T Cell Reconstitution and Potential Role in the Graft-Versus-Leukemia Effect.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 1999/01//
VL - 1
IS - 1
M3 - Article
SP - 7
EP - 19
PB - Taylor & Francis Ltd
SN - 14653249
AB - Background Our laboratory previously reported that leukemia patients who developed ≥ 10% γδ + T cells during the first six months after receiving an anti-TCRαβ T-cell-depleted (TCD) graft from a partially mismatched related donor (PMRD) had a disease-free survival (DFS) advantage. These γδ + T cells were Vδ1 + CD3 + CD4 - CD8 - CD69 + HLADR + and are cytotoxic to K562 cells. Methods In order to determine whether the anti-αβ TCD regimen was associated with these findings, we compared the reconstitution of γδ + T cells from patients who received TCD PMRD grafts using the anti-tCRαβ MAb T10B9-1A31 (previously reported) with similar patients who received grafts using the anti-CD3 MAb OKT3. Results Increased cytotoxic Vδ1+ T cells were seen in 10 of 43 T10B9 TCD patients compared to 7 of 100 in the OKT3 TCD group (23% versus 7%, p = 0.010 ). T10B9 patients with increased γδ + T cells also exhibited a higher range of increased γδ + T cells and the length of time the γδ + T cells remained high was longer when compared to OKT3 patients. Patients with increased γδ + T cells whose grafts were T-cell depleted with T10B9 showed a significant decrease in relapse ( p = 0.038 ). Similar rates and reduction in relapse were seen in OKT3 TCD patients, although significance was not reached due to the small number of patients with increased γδ + T cells. Estimated 3 year disease-free survival was significantly improved in T10B9 patients with increased γδ + T cells (0.79 versus 0.31, p = 0.009 ), a trend also seen in OKT3 patients ( p = 0.091 ). Discussion These observations indicate that Vδ1 + CD4 - CD8 - cytotoxic T cells are associated with lower relapse rates and improved survival, and thus may have a role in a graft-versus-leukemia effect. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cytotherapy (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - GRAFT versus host disease
KW - LEUKEMIA
KW - ANTINEOPLASTIC agents
KW - BONE marrow -- Transplantation
KW - γδ+
N1 - Accession Number: 10909567; Lamb Jr, LS 1 Gee, AP Hazlett, LJ Musk, P 1 Parrish, RS O'Hanlon, TP 2 Geier, SS 1 Folk, RS 1 Harris, WG 1 McPherson, K 1 Lee, C 1 Henslee-Downey, PJ 1; Affiliation: 1: Division of Transplantation Medicine, Palmetto Richland Memorial Hospital, Center for Cancer Treatment and Research, University of South Carolina School of Medicine, Columbia, South Carolina, USA 2: United States Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Jan1999, Vol. 1 Issue 1, p7; Subject Term: T cells; Subject Term: GRAFT versus host disease; Subject Term: LEUKEMIA; Subject Term: ANTINEOPLASTIC agents; Subject Term: BONE marrow -- Transplantation; Author-Supplied Keyword: γδ+; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, John E.
AU - Wilson, Ronald
AU - Doll, Lynda
AU - Jones, T. Stephen
AU - Barker, Peggy
T1 - Condom Use and HIV Risk Behaviors Among U.S. Adults: Data from a National Survey.
JO - Family Planning Perspectives
JF - Family Planning Perspectives
Y1 - 1999/01//Jan/Feb99
VL - 31
IS - 1
M3 - Article
SP - 24
EP - 28
PB - Guttmacher Institute, Inc.
SN - 00147354
AB - Context: How much condom use among U.S. adults varies by type of partner or by risk behavior is unclear. Knowledge of such differentials would aid in evaluating the progress being made toward goals for levels of condom use as part of the Healthy People 2000 initiative. Methods: Data were analyzed from the 1996 National Household Survey of Drug Abuse, an annual household-based probability sample of the noninstitutionalized population aged 12 and older that measures the use of illicit drugs, alcohol and tobacco. The personal behaviors module included 25 questions covering sexual activity in the past year, frequency of condom use in the past year, circumstances of the last sexual encounter and HIV testing. Results: Sixty-two percent of adults reported using a condom at last intercourse outside of an ongoing relationship, while only 19% reported using condoms when the most recent intercourse occurred within a steady relationship. Within ongoing relationships, condom use was highest among respondents who were younger, black, of lower income and from large metropolitan areas. Forty percent of unmarried adults used a condom at last sex, compared with the health objective of 50% for the year 2000. Forty percent of injecting drug users used condoms at last intercourse, compared with the 60% condom use objective for high-risk individuals. Significantly, persons at increased risk for HIV because of their sexual behavior or drug use were not more likely to use condoms than were persons not at increased risk; only 22% used condoms during last intercourse within an ongoing relationship. Conclusions: Substantial progress has been made toward national goals for increasing condom use. The rates of condom use by individuals at high risk of HIV need to be increased, however, particularly condom use with a steady partner. [ABSTRACT FROM AUTHOR]
AB - Copyright of Family Planning Perspectives is the property of Guttmacher Institute, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONDOMS
KW - ADULTS
KW - HIV (Viruses)
KW - RISK-taking (Psychology)
KW - SEXUAL intercourse
KW - UNITED States
N1 - Accession Number: 1657105; Anderson, John E. 1 Wilson, Ronald Doll, Lynda 2 Jones, T. Stephen 3 Barker, Peggy 4; Affiliation: 1: Sociologist, Division of HIV/AIDS Prevention - Intervention, Research and Support, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta 2: Chief, Behavioral Intelligence Research Branch, Division of HIV/AIDS Prevention - Intervention, Research and Support, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta 3: Assistant Director for Science, Division of HIV/AIDS Prevention - Intervention, Research and Support, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta 4: Survey Statistician, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: Jan/Feb99, Vol. 31 Issue 1, p24; Subject Term: CONDOMS; Subject Term: ADULTS; Subject Term: HIV (Viruses); Subject Term: RISK-taking (Psychology); Subject Term: SEXUAL intercourse; Subject Term: UNITED States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 5705
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Godar, Dianne E.
T1 - UVA1 Radiation Triggers Two Different Final Apoptotic Pathways.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 1999/01//
VL - 112
IS - 1
M3 - Article
SP - 3
EP - 12
SN - 0022202X
AB - Because ultraviolet-A1 (UVA1; 340–400 nm) radiation is used therapeutically, this in vitro study addressed the question “how does it work?” To begin addressing this question, UVA1 radiation was first established to reduce the survival of transformed T and B lymphocytes in a linear dose-dependent manner using clonogenic reproductive assays, and that cell death occurs by apoptosis using transmission electron microscopy, Annexin V, and flow cytometry. The primary mechanism was determined to be immediate pre-programmed cell death, an apoptotic mechanism that does not require protein synthesis post-insult, by quantifying the apoptotic cells over time in the absence or presence of a translation inhibitor. To explore how UVA1 radiation induces immediate pre-programmed cell death apoptosis, reactive oxygen species and mitochondrial activity were altered during exposure using a variety of agents, while a specific fluorescent probe, 5,5′,6,6′tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbo-cyanine iodide, was used to examine mitochondrial transmembrane depolarization. To show that UVA1 mediates singlet-oxygen damage to the mitochondrial membranes, X-rays, UVB (290–320 nm), 8-methoxypsoralen and UVA, vitamin K3, anti-Fas antibody, and blocking antibody were the negative controls, while rose bengal or protoporphyrin IX with visible light were the positive controls. Cyclosporine A, which inhibits the mitochondrial megapore from opening, was used with singlet-oxygen and superoxide-anion generators to distinguish between the two final apoptotic pathways. The collective results show that UVA1 radiation primarily mediates singlet-oxygen damage triggering immediate pre-programmed cell death apoptosis (T < 20 min) by immediately opening the cyclosporine A-sensitive (“S” site) mitochondrial megapore, while superoxide anions initiate another cyclosporine A-insensitive (“P” site) final... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - CELL death
KW - TRANSMISSION electron microscopy
KW - LIPOCORTINS
KW - FLOW cytometry
KW - apoptosis
KW - cyclosporine A
KW - mitochondrial transmembrane potential
KW - reactive oxygen species
N1 - Accession Number: 5167134; Godar, Dianne E. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, U.S.A.; Source Info: Jan1999, Vol. 112 Issue 1, p3; Subject Term: ULTRAVIOLET radiation; Subject Term: CELL death; Subject Term: TRANSMISSION electron microscopy; Subject Term: LIPOCORTINS; Subject Term: FLOW cytometry; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: cyclosporine A; Author-Supplied Keyword: mitochondrial transmembrane potential; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 10p; Illustrations: 4 Black and White Photographs, 1 Diagram, 20 Graphs; Document Type: Article
L3 - 10.1046/j.1523-1747.1999.00474.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - Keynote Address.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 225S
EP - 226S
SN - 00223166
N1 - Accession Number: 96710957; Woodcock, Janet 1; Affiliation: 1: Center for Drugs, Food and Drug Administration, Rockville, Maryland 20852; Source Info: Jan99, Vol. 129 Issue 1, p225S; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mann, Marianne
T1 - Approved Pharmacologic Interventions for Wasting: An Overview and Lessons Learned.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 303S
EP - 305S
SN - 00223166
N1 - Accession Number: 96710986; Mann, Marianne 1; Affiliation: 1: Division of Reproductive and Urologic Drug Products, Food and Drug Administration, Rockville, MD 20857; Source Info: Jan99, Vol. 129 Issue 1, p303S; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Senior, John R.
AU - Maroni, Bradley J.
T1 - Working Group Session Report: Chronic Renal and Gastrointestinal Disease.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/01//
VL - 129
IS - 1
M3 - Article
SP - 313S
EP - 314S
SN - 00223166
N1 - Accession Number: 96710994; Senior, John R. 1 Maroni, Bradley J. 2; Affiliation: 1: Gastrointestinal Division, Food and Drug Administration, Rockville, Maryland 20857 2: Renal Division, Emory University, Atlanta, Georgia 30322; Source Info: Jan99, Vol. 129 Issue 1, p313S; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garry, V.F.
AU - Burroughs, B.
AU - Tarone, R.
AU - Kesner, J.S.
T1 - Herbicides and adjuvants: an evolving view.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/01//
VL - 15
IS - 1/2
M3 - Article
SP - 159
EP - 167
PB - Sage Publications, Ltd.
SN - 07482337
AB - The present report examines the in vitro genotoxicity (micronucleus assay) of herbicides and adjuvants and reports on an in vivo human study on potential endocrine effects of pesticides, including herbicides. Adjuvants are used in conjunction with 2,4-dichlorophenoxy acetic acid (2,4-D) and other herbicides. Earlier pesticide applier survey results (n=709) show that 59% of the applicators used adjuvants, and the majority of this group used paraffinic oils and/or surfactant mixtures. As a beginning effort to explore the role of adjuvants and herbicides in hormonally based reproductive effects, a prospective, controlled study was performed to analyze blood specimens from three different exposure groups (applicators using herbicides only; applicators using both herbicides and insecticides; and applicators using fumigants in addition to herbicides and insecticides; and a control group composed of other agricultural workers including organic farmers). The applicators and controls were age- and smoking-matched. Study subjects (n=78) were tested before, during, and after completion of pesticide application season for the effects of pesticide products on hormone levels in the bloodstream. Of the applicator exposure groups examined, only the herbicide group showed significant endocrinologic differences from controls. Free testosterone levels were significantly elevated in post-season measurements (p=0.032), and follicle-stimulating hormone (FSH) was significantly decreased at the height of the season (p=0.016) and in the post-season (p=0.010) as compared to controls. These endocrinologic findings are discussed in terms of their possible relationship to potential endocrine effects of herbicides, herbicide contaminants, and adjuvants. In vitro genotoxicity examination compared four different commercially available surfactant mixtures with 12 different commercial herbicide products, including six different chlorophenoxy herbicides. Only one herbicide yielded a significant dose–response curve. All four adjuvants showed positive dose–response effects. These preliminary data suggest that adjuvants are not inert but are toxicologically active components added to herbicide mixtures. Whether adjuvant toxicant effects are additive or are independent of herbicide effects is poorly understood. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBICIDES
KW - IMMUNOLOGICAL adjuvants
KW - GENETIC toxicology
KW - PESTICIDES
KW - adjuvants
KW - herbicides
KW - hormone analysis
KW - human study
KW - Micronucleus assay
N1 - Accession Number: 4745647; Garry, V.F. 1 Burroughs, B. 1 Tarone, R. 2 Kesner, J.S. 3; Affiliation: 1: University of Minnesota, Environmental Medicine and Pathology Program, Minneapolis, Minnesota 2: National Cancer Institute, Epidemiology and Biostatistics Program, Bethesda, Maryland 3: National Institute for Occupational Safety and Health, Experimental Toxicology Branch, Cincinnati, Ohio; Source Info: 1999, Vol. 15 Issue 1/2, p159; Subject Term: HERBICIDES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: GENETIC toxicology; Subject Term: PESTICIDES; Author-Supplied Keyword: adjuvants; Author-Supplied Keyword: herbicides; Author-Supplied Keyword: hormone analysis; Author-Supplied Keyword: human study; Author-Supplied Keyword: Micronucleus assay; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Szücs, G
AU - Új, M
AU - Mihály, I
AU - Deák
T1 - Burden of human rotavirus-associated hospitalizations in three geographic regions of Hungary.
JO - Acta Paediatrica. Supplement
JF - Acta Paediatrica. Supplement
Y1 - 1999/01/02/Jan99 Supplement 426
VL - 88
IS - s426
M3 - Article
SP - 61
EP - 65
PB - Wiley-Blackwell
SN - 08035326
AB - Data on hospital admissions and laboratory reports were used to estimate the number of hospitalizations of children aged 14 y or less in three geographic regions of Hungary due to group A rotavirus infection. Between January 1993 and December 1996, 9182 hospitalizations for gastroenteritis occurred, of which 1946 (21%) were associated with rotavirus infection. Most (90%) ofthe rotavirus detections were among children aged 4 y or less. By extrapolation, an estimated 5000 rotavirus-related hospitalizations (8.4/1000 children aged 4 y or less/y) occurred in Hungary during the study period. Marked seasonality of rotavirus infections was observed, with a peak of incidence from December to February. Rotaviruses with 'long' RNA electropherotypes predominated each year, but in 1995/1996 20% of electropherotypes in the Budapest area were 'short'. Effective surveillance is required for all children hospitalized for diarrhoea as part of a rotavirus immunization program in Hungary. □ Age group, burden, electropherotypes, Hungaiy, region, rotavirus, season [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Paediatrica. Supplement is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - HOSPITAL care
KW - INFECTION in children
KW - DIARRHEA in children
KW - IMMUNIZATION of children
KW - HUNGARY
N1 - Accession Number: 63460707; Szücs, G 1 Új, M 1 Mihály, I 2 Deák 3; Affiliation: 1: Laboratory of Virology, Albert Szent-Györgyi Medical University, Szeged, Hungary 2: Baranya County Institute of National Public Health Service, Pécs; Laboratory of Virology, Albert Szent-Györgyi Medical University, Szeged, Hungary 3: Szent László Central Hospital for Infectious Diseases, Budapest; and Department of Clinical Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary; Source Info: Jan99 Supplement 426, Vol. 88 Issue s426, p61; Subject Term: ROTAVIRUSES; Subject Term: HOSPITAL care; Subject Term: INFECTION in children; Subject Term: DIARRHEA in children; Subject Term: IMMUNIZATION of children; Subject Term: HUNGARY; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1651-2227.1999.tb14328.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ozawa, Shogo
AU - Shimizu, Makiko
AU - Katoh, Takahiko
AU - Miyajima, Atsuko
AU - Ohno, Yasuo
AU - Matsumoto, Yoshiaki
AU - Fukuoka, Masamichi
AU - Tang, Yong-Ming
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A3*1 (213Arg) and ST1A3*2 (213His), Both of Which Exist in Japanese as Well as Caucasians1.
JO - Journal of Biochemistry
JF - Journal of Biochemistry
Y1 - 1999/01/08/
VL - 126
IS - 2
M3 - Article
SP - 271
EP - 277
SN - 0021924X
N1 - Accession Number: 80085812; Ozawa, Shogo 1 Shimizu, Makiko 1,2 Katoh, Takahiko 3 Miyajima, Atsuko 1 Ohno, Yasuo 1 Matsumoto, Yoshiaki 2 Fukuoka, Masamichi 2 Tang, Yong-Ming 4 Lang, Nicholas P. 5,6 Kadlubar, Fred F. 4; Affiliation: 1: Division of Pharmacology, National Institute of Health Sciences 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501 2: Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 3: Department of Health Science Information, School of Health Sciences, University of Occupational and Environmental Health Kitakyushu 807 4: Division of Molecular Epidemiology (HFT-100), National Center for Toxicological Research Jefferson, AR 72079, USA 5: John L. McCleUan, Veterans Administration Hospital Little Rock, AR 72205, USA 6: Arkansas Cancer Research Center Little Rock, AR 72205, USA; Source Info: 1999, Vol. 126 Issue 2, p271; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mouhyi, Jaafar
AU - Sennerby, Lars
AU - Nammour, Samir
AU - Guillaume, Patrick
AU - Van Reck, Jack
T1 - Temperature increases during surface decontamination of titanium implants using CO2 laser.
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
Y1 - 1999/02//
VL - 10
IS - 1
M3 - Article
SP - 54
EP - 61
SN - 09057161
AB - The purpose of the present in vitro investigation was to measure temperature changes at the implant surface when using pulsed CO2 laser in a simulated implant surface decontamination protocol. Six threaded titanium implants were placed in a fresh resected pig mandible. A 4x4 mm defect was created buccally to each implant in order to expose the implant head and approximately 5 threads. Temperature changes were monitored by two thermocouples placed near the dehiscence and at the apical part of the implant. Several setting combinations of the CO2 laser with regard to output power, pulse width, pulse repetition rate and irradiation time were tested on dry and wet (distilled water) surfaces. Only minor temperature increases were measured when lasing wet titanium surfaces, while the temperature at dry surfaces exceeded the proposed thresholds for bone damage at clinically relevant settings. It is concluded that the CO2 laser when used on a wet implant surface in a pulsed mode at 8 W/l0 ms/ 20 hz during 5 s induces a temperature increase of less than 3oC. This would minimize the risk of temperature induced tissue damage as a result of lasing implant surfaces. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Oral Implants Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL implants
KW - CARBON dioxide lasers
KW - CO
KW - decontamination
KW - ITI implant system
KW - Temperature increase
KW - titanium implants
N1 - Accession Number: 5789203; Mouhyi, Jaafar 1,2 Sennerby, Lars 3,4 Nammour, Samir 1,2 Guillaume, Patrick 5 Van Reck, Jack 1,2; Affiliation: 1: Department of Oral and Maxillo-Facial Surgery, St Pierre University Hospital, Brussels, Belgium; 2: School of Medicine, Free University of Brussels, Belgium; 3: Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, University of Göteborg, Sweden; 4: Brånemark Clinic, Public Health Service, City of Göteborg, Sweden; 5: Department of Electrical Engineering, Vrije Universiteit, Brussels, Belgium; Source Info: Feb1999, Vol. 10 Issue 1, p54; Subject Term: DENTAL implants; Subject Term: CARBON dioxide lasers; Author-Supplied Keyword: CO; Author-Supplied Keyword: decontamination; Author-Supplied Keyword: ITI implant system; Author-Supplied Keyword: Temperature increase; Author-Supplied Keyword: titanium implants; Number of Pages: 8p; Document Type: Article
L3 - 10.1034/j.1600-0501.1999.100107.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ambrosone, Christine B.
AU - Coles, Brian F.
AU - Freudenheim, Jo L.
AU - Shields, Peter G.
T1 - Glutathione-S-transferase (GSTM1) Genetic Polymorphisms Do Not Affect Human Breast Cancer Risk, Regardless of Dietary Antioxidants.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 1999/02//
VL - 129
IS - 2
M3 - Article
SP - 565S
EP - 568S
SN - 00223166
AB - Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of a-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - antioxidants
KW - breast neoplasms
KW - epidemiology/molecular
KW - glutathione-S-transferase
KW - oxidative stress
N1 - Accession Number: 96711791; Ambrosone, Christine B. 1 Coles, Brian F. 1 Freudenheim, Jo L. 2 Shields, Peter G. 3; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079 2: Department of Social & Preventive Medicine, State University of New York at Buffalo, Buffalo, NY 14214 3: Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892; Source Info: Feb99, Vol. 129 Issue 2, p565S; Author-Supplied Keyword: antioxidants; Author-Supplied Keyword: breast neoplasms; Author-Supplied Keyword: epidemiology/molecular; Author-Supplied Keyword: glutathione-S-transferase; Author-Supplied Keyword: oxidative stress; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Will, Julie C.
AU - Denny, Clark
AU - Serdula, Mary
AU - Muneta, Ben
T1 - Trends in Body Weight Among American Indians: Findings From a Telephone Survey, 1985 Through 1996.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/03//
VL - 89
IS - 3
M3 - Article
SP - 395
EP - 398
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study compared trends in body mass index for American Indian men and women across selected regions of the United States. Methods. Self-reported data were collected from the Behavioral Risk Factor Surveillance System. Results. Among women in the Dakotas, New Mexico and Arizona. and Washington and Oregon, average adjusted body mass index increased significantly by 0.1 to 0.2 units per year. Among men in Alaska and the Dakotas, average adjusted body mass index also increased significantly by 0.1 to 0.2 units each year. Conclusions. Because of rapid increases in average body mass index, some American indian populations could be burdened by an increased incidence of chronic disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BODY mass index
KW - NATIVE Americans
KW - TELEPHONE surveys
KW - BODY weight
KW - CHRONIC diseases
KW - UNITED States
N1 - Accession Number: 1606381; Will, Julie C. 1; Email Address: jxw6@cdc.gov Denny, Clark 1 Serdula, Mary 1 Muneta, Ben 2; Affiliation: 1: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Epidemiology Program, Headquarters West, Indian Health Service, Albuquerque, NM; Source Info: Mar1999, Vol. 89 Issue 3, p395; Subject Term: BODY mass index; Subject Term: NATIVE Americans; Subject Term: TELEPHONE surveys; Subject Term: BODY weight; Subject Term: CHRONIC diseases; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gubina, E.
AU - Ruiz-Hidalgo, M. J.
AU - Baladrón, V.
AU - Laborda, J.
T1 - Assignment[sup 1] of DLK1 to human chromosome band 14q32 by in situ hybridization.
JO - Cytogenetics & Cell Genetics
JF - Cytogenetics & Cell Genetics
Y1 - 1999/03//
VL - 84
IS - 3/4
M3 - Article
SP - 206
EP - 207
SN - 03010171
AB - The article throws light on the assignment of delta [Drosophila]-like 1 (DLK1) to human chromosome band 14q32 by in situ hybridization. DLK1 encodes dlk, a transmembrane protein that participates in cell-to-cell interactions during differentiation. The functional importance of dlk in the control of cellular differentiation has been shown in several cell types including small cell lung cancer cell lines, preadipocytes, immune stem cells hematopoietic stromal cells and adrenal glornerulosa cells. Chromosome mapping of this gene may be important to explore whether gene deletion or duplication may be associated with diseases or defaults in embryonic development.
KW - GENE mapping
KW - CHROMOSOME banding
KW - IN situ hybridization
KW - HUMAN chromosomes
KW - CELL differentiation
KW - HUMAN genetics
KW - HEMATOPOIETIC stem cells
N1 - Accession Number: 12184448; Gubina, E. 1 Ruiz-Hidalgo, M. J. 1 Baladrón, V. 1 Laborda, J. 1; Email Address: laborda@helix.nih.gov; Affiliation: 1: Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville MD (USA); Source Info: Mar1999, Vol. 84 Issue 3/4, p206; Subject Term: GENE mapping; Subject Term: CHROMOSOME banding; Subject Term: IN situ hybridization; Subject Term: HUMAN chromosomes; Subject Term: CELL differentiation; Subject Term: HUMAN genetics; Subject Term: HEMATOPOIETIC stem cells; Number of Pages: 2p; Document Type: Article
L3 - 10.1159/000015259
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Temple, Robert
AU - Temple, R
T1 - Meta-analysis and epidemiologic studies in drug development and postmarketing surveillance.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/03/03/
VL - 281
IS - 9
M3 - journal article
SP - 841
EP - 844
SN - 00987484
AB - Offers commentary on the potential value of methods of discovery of adverse consequences of drug use as well as the beneficial effects of drugs through epidemiologic methods and meta-analyses. Reference to study in the same issue by Berlin and Colditz.
KW - CLINICAL drug trials
KW - META-analysis
KW - MEDICAL research
KW - CLINICAL pharmacology
N1 - Accession Number: 1591316; Temple, Robert Temple, R 1; Affiliation: 1: Center for Drug Evaluation & Research, Food and Drug Administration, Rockville, MD 20857, USA; Source Info: 3/3/99, Vol. 281 Issue 9, p841; Subject Term: CLINICAL drug trials; Subject Term: META-analysis; Subject Term: MEDICAL research; Subject Term: CLINICAL pharmacology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mahmood, I.
AU - Sahajwalla, C.
T1 - Clinical Pharmacokinetics and Pharmacodynamics of Buspirone, an Anxiolytic Drug.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 1999/04//
VL - 36
IS - 4
M3 - Article
SP - 277
EP - 287
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Buspirone is an anxiolytic drug given at a dosage of 15 mg/day. The mechanism of action of the drug is not well characterised, but it may exert its effect by acting on the dopaminergic system in the central nervous system or by binding to serotonin (5-hydroxytryptamine) receptors. Following a oral dose of buspirone 20mg, the drug is rapidly absorbed. The mean peak plasma concentration (C) is approximately 2.5 µg/L, and the time to reach the peak is under 1 hour. The absolute bioavailability of buspirone is approximately 4%. Buspirone is extensively metabolised. One of the major metabolites of buspirone is 1-pyrimidinylpiperazine (1-PP), which may contribute to the pharmacological activity of buspirone. Buspirone has a volume of distribution of 5.3 L/kg, a systemic clearance of about 1.7 L/h/kg, an elimination half-life of about 2.5 hours and the pharmacokinetics are linear over the dose range 10 to 40mg. After multiple-dose administration of buspirone 10 mg/day for 9 days, there was no accumulation of either parent compound or metabolite (1-PP). Administration with food increased the C and area under the plasma concentration-time curve (AUC) of buspirone 2-fold. After a single 20mg dose, the C and AUC increased 2-fold in patients with renal impairment as compared with healthy volunteers. The C and AUC were 15-fold higher for the same dose in patients with hepatic impairment compared with healthy individuals. The half-life of buspirone in patients with hepatic impairment was twice that in healthy individuals. The pharmacokinetics of buspirone were not affected by age or gender. Coadministration of buspirone with verapamil, diltiazem, erythromycin and itraconazole substantially increased the plasma concentration of buspirone, whereas cimetidine and alprazolam had negligible effects. Rifampicin (rifampin) decreased the plasma concentrations of buspirone almost 10-fold. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BUSPIRONE
KW - TRANQUILIZING drugs
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - Alprazolam, drug-interactions
KW - Anxiolytics, pharmacokinetics
KW - Buspirone, drug-interactions
KW - Buspirone, pharmacokinetics
KW - Cimetidine, drug-interactions
KW - Clinical-pharmacokinetics
KW - Diltiazem, drug-interactions
KW - Drug-interactions
KW - Erythromycin, drug-interactions
KW - Food
KW - Itraconazole, drug-interactions
KW - Reviews-on-treatment
KW - Rifampicin, drug-interactions
KW - Verapamil, drug-interactions
N1 - Accession Number: 9523143; Mahmood, I. 1 Sahajwalla, C. 1; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Division of Pharmaceutical Evaluation I, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 1999, Vol. 36 Issue 4, p277; Subject Term: BUSPIRONE; Subject Term: TRANQUILIZING drugs; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Author-Supplied Keyword: Alprazolam, drug-interactions; Author-Supplied Keyword: Anxiolytics, pharmacokinetics; Author-Supplied Keyword: Buspirone, drug-interactions; Author-Supplied Keyword: Buspirone, pharmacokinetics; Author-Supplied Keyword: Cimetidine, drug-interactions; Author-Supplied Keyword: Clinical-pharmacokinetics; Author-Supplied Keyword: Diltiazem, drug-interactions; Author-Supplied Keyword: Drug-interactions; Author-Supplied Keyword: Erythromycin, drug-interactions; Author-Supplied Keyword: Food; Author-Supplied Keyword: Itraconazole, drug-interactions; Author-Supplied Keyword: Reviews-on-treatment; Author-Supplied Keyword: Rifampicin, drug-interactions; Author-Supplied Keyword: Verapamil, drug-interactions; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roe, Brian
AU - Whittington, Leslie A.
AU - Fein, Sara Beck
AU - Teisl, Mario F.
T1 - IS THERE COMPETITION BETWEEN BREAST-FEEDING AND MATERNAL EMPLOYMENT?
JO - Demography
JF - Demography
Y1 - 1999/05//
VL - 36
IS - 2
M3 - Article
SP - 157
EP - 171
SN - 00703370
AB - This article examines the relationship between maternal employment and breastfeeding responsibilities of mothers using the 1993-1994 data from the U.S. Food and Drug Administration's Infant Feeding Practices Study. The perceived competition between work and family is a topic of considerable current policy interest. One area of incompatibility for women is the balance between market work and breast-feeding. Researchers estimate a set of simultaneous models of maternal employment and infant-feeding decisions suggested by the competing demands of the two activities. The duration of maternal work leave is positively related to the duration of breast-feeding. The intensity of a woman's market work is negatively related to the intensity of her breast-feeding activity. The opportunity cost of breast-feeding reflects it's impact on the length of leave from work and on the intensity of work upon return to the job. They use data from the prenatal intake survey and some or all of the postpartum surveys to determine the intensity of breast-feeding and work-leave behaviors at specific infant ages.
KW - WORKING mothers
KW - BREASTFEEDING (Humans)
KW - MOTHER & infant
KW - DEMOGRAPHIC surveys
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 2427520; Roe, Brian 1 Whittington, Leslie A. 2 Fein, Sara Beck 3; Email Address: sfein@bangatc.fda.gov Teisl, Mario F. 4; Affiliation: 1: Ohio State University, Department of Agricultural Economics. 2: Georgetown Public Policy Institute, Georgetown University. 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-727, 200 C Street, SW, Washington, DC 20204. 4: Department of Resource Economics and Policy, University of Maine.; Source Info: May99, Vol. 36 Issue 2, p157; Subject Term: WORKING mothers; Subject Term: BREASTFEEDING (Humans); Subject Term: MOTHER & infant; Subject Term: DEMOGRAPHIC surveys; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 15p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie R.
T1 - African American service use for mental health problems.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 1999/05//
VL - 27
IS - 3
M3 - Article
SP - 303
EP - 313
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - The present study examined racial differences in use of mental health services in the specialty mental health and general medical sectors of care. Data came from household and institutional surveys and permitted estimation of services use both in the general population alone and when supplemented with samples of persons confined in jails, prisons, and mental hospitals. In uncontrolled analysis, African Americans in the community presented a mixed pattern of under-, equal-, and overrepresentation in services. Weighting the sample and controlling for sociodemographic differences and diagnoses yielded results indicating that African Americans in the community were consistently less likely than Whites to have sought help. Adding to the analysis persons who were confined eliminated the disparity in the general medical-sector services and reduced the disparity in specialty mental health sector services. Conclusions as to parity and underutilization of mental health services vary with methodological factors linked to adverse social circumstances of African American life. © 1999 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFRICAN Americans -- Medical care
KW - AFRICAN Americans -- Mental health
KW - SOCIAL status
KW - COMMUNITY psychology
KW - RACE discrimination in mental health services
KW - HEALTH—MENTAL
N1 - Accession Number: 11771721; Snowden, Lonnie R. 1; Affiliation: 1: Center for Mental Health Services Research and School of Social Welfare, University of California, Berkeley.; Source Info: May1999, Vol. 27 Issue 3, p303; Subject Term: AFRICAN Americans -- Medical care; Subject Term: AFRICAN Americans -- Mental health; Subject Term: SOCIAL status; Subject Term: COMMUNITY psychology; Subject Term: RACE discrimination in mental health services; Author-Supplied Keyword: HEALTH—MENTAL; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Stayner, Leslie
T1 - Protecting Public Health in the Face of Uncertain Risks: The Example of Diesel Exhaust.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/07//
VL - 89
IS - 7
M3 - Editorial
SP - 991
EP - 993
PB - American Public Health Association
SN - 00900036
AB - The article examines the challenges being faced by U.S. regulatory agencies of performing risk assessments for occupational and environmental exposures to diesel exhaust. The severe burden posed by formal risk assessments, required for setting occupational and environmental health standards have caused delays in the development of effective standards. The problem associated with the issue prompted some environmentalists to question the utility of risk assessments for addressing current public health problems.
KW - HEALTH risk assessment
KW - ENVIRONMENTAL risk assessment
KW - PUBLIC health -- United States
KW - DIESEL motor exhaust gas
KW - UNITED States
N1 - Accession Number: 2009949; Stayner, Leslie 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Jul99, Vol. 89 Issue 7, p991; Subject Term: HEALTH risk assessment; Subject Term: ENVIRONMENTAL risk assessment; Subject Term: PUBLIC health -- United States; Subject Term: DIESEL motor exhaust gas; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - How-Ran Guo
AU - Tanaka, Shiro
AU - Halperin, William E.
AU - Cameron, Lorraine L.
T1 - Back Pain Prevalence in US Industry and Estimates of Lost Workdays.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/07//
VL - 89
IS - 7
M3 - Article
SP - 1029
EP - 1035
PB - American Public Health Association
SN - 00900036
AB - Objectives. Back pain is the most common reason for filing workers' compensation claims and often causes lost workdays. Data from the 1988 National Health Interview Survey were analyzed to identify high-risk industries and to estimate the prevalence of work-related back pain and number of workdays lost. Methods. Analyses included 30074 respondents who worked during the 12 months before the interview. A case patient was defined as a respondent who had back pain every day for a week or more during that period. Result. The prevalence of lost-workday back pain was 4.6%, and individuals with work-related cases lost 101. .8 million workdays owing to back pain. Male and female case patients lost about the same number of work-days. Industries in high-risk categories were also identified for future research and interventions, including those seldom studied. Conclusions. This study provides statistically reliable national estimates of the prevalence of back pain among workers and the enormous effect of this condition on American industry in terms of lost workdays. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACKACHE
KW - OCCUPATIONAL diseases
KW - WORKING hours
KW - ABSENTEEISM (Labor)
KW - SICK leave -- United States
KW - UNITED States
N1 - Accession Number: 2009959; How-Ran Guo 1,2; Email Address: hrguo@mail.ncku.edu.tw Tanaka, Shiro 1 Halperin, William E. 1 Cameron, Lorraine L. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan; Source Info: Jul99, Vol. 89 Issue 7, p1029; Subject Term: BACKACHE; Subject Term: OCCUPATIONAL diseases; Subject Term: WORKING hours; Subject Term: ABSENTEEISM (Labor); Subject Term: SICK leave -- United States; Subject Term: UNITED States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, R.
AU - Sun, H.
AU - Hossain, M.
AU - Fadiran, E.O.
AU - Ette, E.I.
AU - Jones, C.D.
AU - Lesko, L.
AU - Huang, S.
AU - Higgins, K.
AU - Hu, C.
AU - Machado, S.
AU - Maldonado, S.
T1 - Population Pharmacokinetics: A Regulatory Perspective.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 1999/07//
VL - 37
IS - 1
M3 - Article
SP - 41
EP - 58
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - The application of population approaches to drug development is recommended in several US Food and Drug Administration (FDA) guidance documents. Population pharmacokinetic (and pharmacodynamic) techniques enable identification of the sources of inter- and intra-individual variability that impinge upon drug safety and efficacy. This article briefly discusses the 2-stage approach to the estimation of population pharmacokinetic parameters, which requires serial multiple measurements on each participant, and comprehensively reviews the nonlinear mixed-effects modelling approach, which can be applied in situations where extensive sampling is not done on all or any of the participants. Certain preliminary information, such as the compartment model used in describing the pharmacokinetics of the drug, is required for a population pharmacokinetic study. The practical design considerations of the location of sampling times, number of samples/participants and the need to sample an individual more than once should be borne in mind. Simulation may be useful for choosing the study design that will best meet study objectives. The objectives of the population pharmacokinetic study can be secondary to the objectives of the primary clinical study (in which case an add-on population pharmacokinetic protocol may be needed) or primary (when a stand-alone protocol is required). Having protocols for population pharmacokinetic studies is an integral part of ‘good pharmacometric practice’. Real-time data assembly and analysis permit an ongoing evaluation of site compliance with the study protocol and provide the opportunity to correct violations of study procedures. Adequate policies and procedures should be in place for study blind maintenance. Real-time data assembly creates the opportunity for detecting and correcting errors in concentration-time data, drug administration history and covariate data. Population pharmacokinetic analyses may be undertaken in 3 interwoven steps: exploratory data analysis, model development and model validation (i.e. predictive performance). Documentation for regulatory purposes should include a complete inventory of key runs in the analyses undertaken (with flow diagrams if possible), accompanied by articulation of objectives, assumptions and hypotheses. Use of diagnostic analyses of goodness of fit as evidence of reliability of results is advised. Finally, the use of stability testing or model validation may be warranted to support label claims. The opinions expressed in this article were revised by incorporating comments from various sources and published by the FDA as ‘Guidance for Industry: Population Pharmacokinetics’ (see the FDA home page http://www.fda.gov for further information). [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - CLINICAL epidemiology
KW - Clinical-trial-design
KW - Population-pharmacokinetics
N1 - Accession Number: 9523185; Williams, R. 1 Sun, H. 1 Hossain, M. 2 Fadiran, E.O. 1 Ette, E.I. 3 Jones, C.D. 4 Lesko, L. 1 Huang, S. 1 Higgins, K. 1 Hu, C. 1 Machado, S. 1 Maldonado, S. 5; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 2: Novartis Pharmaceuticals, East Hanover, New Jersey, USA 3: Vertex Pharmaceuticals, Cambridge, Massachusetts, USA 4: Solvay Pharmeceutical, Marieta, Georgia, USA 5: Boehringer Ingelheim Pharmeceuticals, Ridgefield, Connecticut, USA; Source Info: 1999, Vol. 37 Issue 1, p41; Subject Term: PHARMACOKINETICS; Subject Term: CLINICAL epidemiology; Author-Supplied Keyword: Clinical-trial-design; Author-Supplied Keyword: Population-pharmacokinetics; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robinowitz, M
AU - Gutman, SI
T1 - FDA's New Regulatory Paradigms for in vitro Diagnostic Devices.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 1999/07//
VL - 1
IS - 4
M3 - Article
SP - 353
EP - 357
PB - Taylor & Francis Ltd
SN - 14653249
AB - Presents a summary of the response of the U.S. Food and Drug Administration (FDA) as of July 1999, to statutory requirements imposed by the U.S. Congress through the FDA Modernization Act of 1997. Definition given for in vitro diagnostic devices; Requirements of the Safe Medical Devices Act of 1990; Requirements of the FDA Analyte Specific Reagent Rules for manufacturers; Development of the Compliance Policy Guide by the FDA Center for Devices and Radiologic Health Office for Compliance.
KW - MEDICAL equipment
KW - MEDICAL supplies
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 10909537; Robinowitz, M 1 Gutman, SI 1; Affiliation: 1: Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jul1999, Vol. 1 Issue 4, p353; Subject Term: MEDICAL equipment; Subject Term: MEDICAL supplies; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, S. Lori
AU - Hansen, Sharon L.
AU - Langone, John J.
AU - Brown, S L
AU - Hansen, S L
AU - Langone, J J
T1 - Role of serology in the diagnosis of Lyme disease.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/07/07/
VL - 282
IS - 1
M3 - journal article
SP - 62
EP - 66
SN - 00987484
AB - Numerous concerns regarding the potential for misdiagnosis of Lyme disease using commercial assays have been voiced by the US Food and Drug Administration (FDA). We attempted to clarify the clinical value of serologic testing for Lyme disease using the results of commonly marketed assays for detecting antibody to Borrelia burgdorferi, the organism that causes Lyme disease. We reviewed published studies on B burgdorferi test performance published through 1998, package insert labeling from FDA-cleared test kits for B burgdorferi, and Lyme Disease Survey Set LY-A from the College of American Pathologists. We assessed the sensitivity and specificity of commercial serologic tests (enzyme-linked immunosorbent assay [ELISA], immunofluorescence antibody [IFA], and immunodot) for diagnosis of Lyme disease. To reduce this risk of misdiagnosis, it is important that clinicians understand the performance characteristics and limitations of these tests. These tests, in common use in clinical or commercial laboratories, should be used only to support a clinical diagnosis of Lyme disease, not as the primary basis for making diagnostic or treatment decisions. Serologic testing is not useful early in the course of Lyme disease because of the low sensitivity of tests in early disease. Serologic testing may be more useful in later disease, at which time sensitivity and specificity of the test are improved. Positive or equivocal results on an ELISA, IFA, or immunodot assay requires supplemental testing with a Western blot assay. A negative result on the Western blot or ELISA indicates that there is no serologic evidence of infection by B burgdorferi at the time the sample was drawn. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYME disease -- Diagnosis
KW - SEROLOGY
KW - RELAPSING fever
KW - HEMATOLOGY
KW - UNITED States
N1 - Accession Number: 2004616; Brown, S. Lori Hansen, Sharon L. Langone, John J. Brown, S L 1 Hansen, S L Langone, J J; Affiliation: 1: Division of Postmarket Surveillance, Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA; Source Info: 7/7/99, Vol. 282 Issue 1, p62; Subject Term: LYME disease -- Diagnosis; Subject Term: SEROLOGY; Subject Term: RELAPSING fever; Subject Term: HEMATOLOGY; Subject Term: UNITED States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: journal article
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ER -
TY - JOUR
AU - Kanegane, Hirokazu
AU - Miyawaki, Toshio
AU - Yachie, Akihiro
AU - Oh-Ishi, Tsutomu
AU - Bhatia, Kishor
AU - Tosato, Giovanna
T1 - Development of EBV-Positive T-Cell Lymphoma Following Infection of Peripheral Blood T Cells with EBV.
JO - Leukemia & Lymphoma
JF - Leukemia & Lymphoma
Y1 - 1999/08//
VL - 34
IS - 5/6
M3 - Article
SP - 603
EP - 607
PB - Taylor & Francis Ltd
SN - 10428194
AB - Chronic active Epstein-Barr virus (EBV) infection is manifested clinically by the persistence of infectious mononucleosis-like symptoms or its complications for a prolonged period ranging from one to several years. This syndrome may include severe disease manifestations and can be fatal. The role of EBV in the pathogenesis of chronic active EBV infection has been unclear. We investigated two Japanese patients with severe chronic active EBV infection who subsequently developed EBV-positive T-cell lymphoma. We found that the patients had evidence of EBV infection in the peripheral blood CD4* T-cells 19 and 3 months, respectively, before the T-cell lymphoma was diagnosed. The lymphomas were infected with monoclonal EBV and expressed the EBV latency genes EBNA-1, LMP-i, and LMP-2A, a virus latency pattern referred to as latency IL Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable from the virus in the peripheral blood CD4+T-cells. These studies support an important pathogenetic role of T-cell infection with EBV in chronic active EBV infection and in the EBV-positive T-cell lymphoma that followed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Leukemia & Lymphoma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPSTEIN-Barr virus diseases
KW - T cells
KW - HERPESVIRUS diseases
KW - LYMPHOPROLIFERATIVE disorders
KW - LYMPHOMAS
KW - chronic active EBV infection
KW - EBV-positive T-cell lymphoma
KW - Epstein-Barr virus
N1 - Accession Number: 17473979; Kanegane, Hirokazu 1; Email Address: kanegane@ms.toyama-mpu.ac.jp Miyawaki, Toshio 1 Yachie, Akihiro 2 Oh-Ishi, Tsutomu 3 Bhatia, Kishor 4 Tosato, Giovanna 5; Affiliation: 1: Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 9361-8194 2: School of Health Science, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920-0934 3: Saitama Children's Medical Center, Iwatsuki, Saitama 339-0077, Japan 4: Pediatric Oncology Branch, National Cancer Institute, National Institute of Health 5: Division of Hematologic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, U.S.A; Source Info: Aug99, Vol. 34 Issue 5/6, p603; Subject Term: EPSTEIN-Barr virus diseases; Subject Term: T cells; Subject Term: HERPESVIRUS diseases; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: LYMPHOMAS; Author-Supplied Keyword: chronic active EBV infection; Author-Supplied Keyword: EBV-positive T-cell lymphoma; Author-Supplied Keyword: Epstein-Barr virus; Number of Pages: 5p; Illustrations: 1 Black and White Photograph, 1 Diagram; Document Type: Article; Full Text Word Count: 2810
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DB - aph
ER -
TY - JOUR
AU - Temple, Robert
AU - Temple, R
T1 - Are surrogate markers adequate to assess cardiovascular disease drugs?
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/08/25/
VL - 282
IS - 8
M3 - journal article
SP - 790
EP - 795
SN - 00987484
AB - Focuses on the use of surrogate end points as a basis for reaching conclusions about the benefit of its therapeutic use in cardiovascular disease. Defining surrogate end points; Regulatory status of end points; Risk of reliance on a surrogate.
KW - CARDIOVASCULAR diseases -- Treatment
KW - CARDIOVASCULAR system
KW - BLOOD circulation
KW - HEART diseases -- Treatment
N1 - Accession Number: 2182203; Temple, Robert Temple, R 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA; Source Info: 8/25/99, Vol. 282 Issue 8, p790; Subject Term: CARDIOVASCULAR diseases -- Treatment; Subject Term: CARDIOVASCULAR system; Subject Term: BLOOD circulation; Subject Term: HEART diseases -- Treatment; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: journal article
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ER -
TY - JOUR
AU - Fleming, Michael F.
AU - Manwell, Linda Baier
AU - Kraus, Mark
AU - Isaacson, Harry J.
AU - Kahn, Ruth
AU - Stauffacher, Ellyn A.
T1 - Who teaches residents about the prevention and treatment of substance use disorders?
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 1999/09//
VL - 48
IS - 9
M3 - Article
SP - 725
EP - 729
SN - 00943509
AB - BACKGROUND. Studies indicate that physicians are poorly prepared to identify and treat tobacco, alcohol, and drug use disorders. Several faculty development programs have been created to increase the number of residency teaching faculty with expertise in this area. There is limited information, however, on those who currently teach residents about these problems and whether there is a need for additional faculty development programs. METHODS. We conducted a 2-stage national survey of faculty who teach residents about substance use problems. First, residency directors from 7 specialties (family medicine, psychiatry, internal medicine, pediatrics, obstetrics and gynecology, emergency medicine, and osteopathy) responded to a mailed questionnaire asking them to identify faculty who teach residents about substance use disorders. Second, those identified were contacted and asked to participate in a telephone interview. RESULTS. Of 1293 faculty identified by the residency directors, 769 participated in a research interview. Most of these teachers were full-time physician faculty, men, white, and based in departments of family medicine or psychiatry. Teaching was primarily conducted in hospitals, general outpatient clinics, and classrooms rather than alcohol and drug treatment programs. Less than 10% of the faculty performed clinical work in alcohol and drug treatment programs, and only 19% were certified addiction specialists. The respondents reported a definite need for additional development programs for themselves and other residency teaching faculty. CONCLUSIONS. We suggest a modest increase in the number of faculty who teach residents about substance abuse disorders, and the creation of additional faculty development programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Treatment
KW - PHYSICIANS
KW - MEDICAL personnel
KW - FAMILY medicine
KW - PATHOLOGICAL psychology
KW - PERSONALITY disorders
KW - Faculty
KW - medical
KW - schools
KW - schools, medical
KW - substance use disorders
N1 - Accession Number: 2356211; Fleming, Michael F. 1; Email Address: mfleming@fammed.wisc.edu Manwell, Linda Baier 1 Kraus, Mark 2 Isaacson, Harry J. 3 Kahn, Ruth 4 Stauffacher, Ellyn A. 1; Affiliation: 1: University of Wisconsin-Madison Medical School. 2: Yale University School of Medicine, New Haven. 3: Cleveland Clinic Foundation. 4: Division of Medicine, Health Resources and Services Administration.; Source Info: Sep1999, Vol. 48 Issue 9, p725; Subject Term: DRUG abuse -- Treatment; Subject Term: PHYSICIANS; Subject Term: MEDICAL personnel; Subject Term: FAMILY medicine; Subject Term: PATHOLOGICAL psychology; Subject Term: PERSONALITY disorders; Author-Supplied Keyword: Faculty; Author-Supplied Keyword: medical; Author-Supplied Keyword: schools; Author-Supplied Keyword: schools, medical; Author-Supplied Keyword: substance use disorders; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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ER -
TY - JOUR
AU - Vulule, J. M.
AU - Beach, R. F.
AU - Atieli, F. K.
AU - Mcallister, J. C.
AU - Brogdon, W. G.
AU - Roberts, J. M.
AU - Mwangi, R. W.
AU - Hawley, W. A.
T1 - Elevated oxidase and esterase levels associated with permethrin tolerance in Anopheles gambiae from Kenyan villages using permethrin-impregnated nets.
JO - Medical & Veterinary Entomology
JF - Medical & Veterinary Entomology
Y1 - 1999/09//
VL - 13
IS - 3
M3 - Article
SP - 239
EP - 244
PB - Wiley-Blackwell
SN - 0269283X
AB - SummaryThe permethrin tolerance (PT) of a population of the mosquito Anopheles gambiae (Diptera: Culicidae) increased following the introduction of permethrin-impregnated nets for malaria control in certain villages near Kisumu, western Kenya. Using a biochemical test that indirectly measures oxidases associated with permethrin resistance, we found that this population had higher oxidase levels than a comparison population from villages without impregnated nets. Mosquitoes from a colony of An. gambiae selected for PT, the RSP (reduced susceptibility to permethrin) strain, were exposed to permethrin with or without the oxidase inhibitor piperonyl butoxide (PB). Significantly higher mortality rates occurred when permethrin was synergized by PB, presumably by suppression of oxidases responsible for PT. An unselected (UNS) colony of An. gambiae that was more susceptible than RSP in a permethrin-susceptibility bioassay (i.e. LT50 22 min for UNS, vs. 42 min for RSP) was compared with the RSP colony for levels of oxidases and esterases. The levels of both enzymes were very significantly higher in the RSP strain (P < 0.0001). We speculate that use of impregnated nets selected for higher oxidase and esterase levels in An. gambiae to metabolize permethrin acquired from the nets. Both oxidase and esterase mechanisms could confer cross-resistance to other pyrethroids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical & Veterinary Entomology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANOPHELES
KW - OXIDASES
KW - ESTERASES
KW - MALARIA -- Prevention
KW - PESTS -- Control
KW - KENYA
KW - Anopheles gambiae
KW - bednets
KW - bioassays
KW - biochemical assays
KW - esterases
KW - insecticide tolerance
KW - Kenya
KW - Oxidases
KW - permethrin
N1 - Accession Number: 5168467; Vulule, J. M. 1 Beach, R. F. 2 Atieli, F. K. 1 Mcallister, J. C. 2 Brogdon, W. G. 2 Roberts, J. M. 2 Mwangi, R. W. 3 Hawley, W. A. 2; Affiliation: 1: Vector Biology and Control Research Centre (Kenya Medical Research Institute), PO Box 1578, Kisumu, Kenya, 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health & Human Services, Atlanta, GA, U.S.A, and 3: Department of Zoology, University of Nairobi, Kenya; Source Info: Sep99, Vol. 13 Issue 3, p239; Subject Term: ANOPHELES; Subject Term: OXIDASES; Subject Term: ESTERASES; Subject Term: MALARIA -- Prevention; Subject Term: PESTS -- Control; Subject Term: KENYA; Author-Supplied Keyword: Anopheles gambiae; Author-Supplied Keyword: bednets; Author-Supplied Keyword: bioassays; Author-Supplied Keyword: biochemical assays; Author-Supplied Keyword: esterases; Author-Supplied Keyword: insecticide tolerance; Author-Supplied Keyword: Kenya; Author-Supplied Keyword: Oxidases; Author-Supplied Keyword: permethrin; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; Number of Pages: 7p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2915.1999.00177.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Machado, S.
AU - Miller, R.
AU - Hu, C.
AU - Machado, S G
T1 - A regulatory perspective on pharmacokinetic/pharmacodynamic modelling.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 1999/09//
VL - 8
IS - 3
M3 - journal article
SP - 217
EP - 245
PB - Sage Publications, Ltd.
SN - 09622802
AB - We present an integrated summary from statistical and pharmacological perspectives of pharmacokinetic/pharmacodynamic (PK/PD) modelling and its use in drug development and regulation for guiding appropriate dosing. An overview of the technical aspects of PK/PD modelling describes how structural models are constructed and refined using pharmacokinetic and pharmacodynamic principles and how random effects models are used to account for individual differences in desired (and undesired) responses due to patient characteristics. Lastly, we describe applications of PK/PD modelling for the purposes of drug labelling, for resolving a safety concern, and for improving therapeutic monitoring of anaesthetic depth during surgery. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL arithmetic
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - DRUG development
KW - MATHEMATICAL models
N1 - Accession Number: 4164681; Machado, S. 1 Miller, R. 2 Hu, C. 3 Machado, S G 4; Affiliation: 1: Office of Biostatistics 2: Office of Clinical Pharmacology and Biopharmaceutics 3: Office of Biostatistics, Center for Drug Evaluation and Research, US’Food and Drug Administration, Rockville, Maryland, USA 4: Office of Biostatistics, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, USA; Source Info: 1999, Vol. 8 Issue 3, p217; Subject Term: PHARMACEUTICAL arithmetic; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Subject Term: DRUG development; Subject Term: MATHEMATICAL models; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 29p; Document Type: journal article
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ER -
TY - JOUR
AU - Chew, G.L.
AU - Higgins, K.M.
AU - Gold, D.R.
AU - Muilenberg, M.L.
AU - Burge, H.A.
T1 - Monthly measurements of indoor allergens and the influence of housing type in a northeastern US city.
JO - Allergy
JF - Allergy
Y1 - 1999/10//
VL - 54
IS - 10
M3 - Article
SP - 1058
EP - 1066
PB - Wiley-Blackwell
SN - 01054538
AB - Background: We examined seasonal variation of dust‐mite (Der f 1 and Der p 1), cat (Fel d 1), and cockroach (Bla g 1) allergens in Boston, while adjusting for other covariates. Limited data are available on seasonal patterns of indoor allergen concentrations for different geographic regions in the USA. Understanding within‐home seasonal variation of allergens is important epidemiologically and clinically. Methods: From June 1995 to June 1996, dust samples were vacuumed monthly from the bed, bedroom floor, and kitchen of 20 homes. Indoor temperatures were measured monthly and used in calculating relative and absolute humidity. Monthly home characteristics questionnaires were completed by an adult resident of each home. Dust samples were assayed by enzyme‐linked immunosorbent assays. Results: Der f 1 and Der p 1 in beds and floors peaked in the autumn months, Fel d 1 peaked in winter and spring, and Bla g 1 was highest in summer. Dust‐mite allergen concentrations were 1.9–2.4 times higher in autumn than spring, but the levels in beds were 19–31 times higher in houses than those in apartments. Although Fel d 1 levels in beds were 2.4 times higher in spring than summer, homes with cats had levels 224 times higher than those without cats. Similarly, Bla g 1 levels in kitchens were 2.1 times higher in summer than winter, but apartments had levels five times higher than those of houses. Conclusions: Sampling season is a source of within‐home dust‐mite, cat, and cockroach allergen variation in the northeastern USA. However, the influence of housing type and owning a cat far outweighed the seasonal variation of these indoor allergens. Abbreviations: SD: standard deviation; ELISA: enzyme‐linked immunosorbent assay; Aw: water activity; mAb: monoclonal antibody; BSA: bovine serum albumin; PBS: phosphate‐buffered saline; T: Tween 20 solution; BBS: borate‐buffered saline; LOD: limit of... [ABSTRACT FROM AUTHOR]
AB - Copyright of Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - SEASONAL variations of diseases
KW - MASSACHUSETTS
KW - BOSTON (Mass.)
KW - UNITED States
KW - allergens
KW - cat
KW - cockroach
KW - dust mite
KW - seasonal variation
N1 - Accession Number: 5960736; Chew, G.L. 1 Higgins, K.M. 2 Gold, D.R. 3,4 Muilenberg, M.L. 3 Burge, H.A. 3; Affiliation: 1: Division of Environmental Health Sciences, Columbia School of Public Health, New York, NY 2: US Food and Drug Administration, Rockville, MD 3: Department of Environmental Health, Harvard School of Public Health, Boston, MA 4: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Source Info: Oct99, Vol. 54 Issue 10, p1058; Subject Term: ALLERGENS; Subject Term: SEASONAL variations of diseases; Subject Term: MASSACHUSETTS; Subject Term: BOSTON (Mass.); Subject Term: UNITED States; Author-Supplied Keyword: allergens; Author-Supplied Keyword: cat; Author-Supplied Keyword: cockroach; Author-Supplied Keyword: dust mite; Author-Supplied Keyword: seasonal variation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 5 Charts, 6 Graphs; Document Type: Article
L3 - 10.1034/j.1398-9995.1999.00003.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daniel, M.
AU - Green, L.W.
T1 - Community-Based Prevention and Chronic Disease Self-Management Programmes: Problems, Praises and Pitfalls.
JO - Disease Management & Health Outcomes
JF - Disease Management & Health Outcomes
Y1 - 1999/10//
VL - 6
IS - 4
M3 - Article
SP - 185
EP - 192
PB - Springer Science & Business Media B.V.
SN - 11738790
AB - There is considerable merit in undertaking to shift disease patterns at the community level. Typical problems reflect difficulties in the application of community-based prevention programmes, rather than inherent deficiencies in the concept itself. Scientific issues bear as much on successful outcomes as project management and practice considerations. Nonetheless, given their limited success, it can be asked whether advocates of community-based programmes have been carried away with the rhetoric of health promotion, pursuing a romanticised vision of community. In this regard, some of the disappointments that have prevailed in recently published community trials may reflect an intentional avoidance of programmes or activities that serve people on a one-to-one level. The equating of ‘community-based’ with ‘community-wide’ approaches to disease prevention overlooks the fact that social norms are institution-bound as much as they are the product of broader social forces. Future work must address the inward involvement of institutions in changing their own norms, not simply seeking outward cooperation in mass media and community-wide efforts for disease prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Disease Management & Health Outcomes is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - PREVENTIVE health services
KW - HEALTH promotion
KW - Disease-management-programmes
KW - Patient-education
KW - Pharmacoeconomics
N1 - Accession Number: 9523587; Daniel, M. 1 Green, L.W. 2; Affiliation: 1: Department of Health Behaviour and Health Education, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA 2: Office on Smoking and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA; Source Info: Oct99, Vol. 6 Issue 4, p185; Subject Term: PUBLIC health; Subject Term: PREVENTIVE health services; Subject Term: HEALTH promotion; Author-Supplied Keyword: Disease-management-programmes; Author-Supplied Keyword: Patient-education; Author-Supplied Keyword: Pharmacoeconomics; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - de Rosa, C.T.
AU - Brown, D.
AU - Dhara, R.
AU - Garrett, W.
AU - Hansen, H.
AU - Holler, J.
AU - Jones, D.
AU - Jordan-Izaguirre, D.
AU - O'conner, R.
AU - Pohl, H.
AU - Xintaras, C.
T1 - Dioxin and dioxin-like compounds in soil, Part I: ATSDR policy guideline.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/10//
VL - 15
IS - 6
M3 - Article
SP - 552
EP - 557
PB - Sage Publications, Ltd.
SN - 07482337
KW - dioxin
KW - human exposure
KW - risk assessment
KW - SOIL LEVELS
KW - TCDD
KW - TEQs
N1 - Accession Number: 2596482; de Rosa, C.T. 1 Brown, D. 1 Dhara, R. 1 Garrett, W. 1 Hansen, H. 1 Holler, J. 1 Jones, D. 1 Jordan-Izaguirre, D. 1 O'conner, R. 1 Pohl, H. 1 Xintaras, C. 1; Affiliation: 1: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia; Source Info: 1999, Vol. 15 Issue 6, p552; Author-Supplied Keyword: dioxin; Author-Supplied Keyword: human exposure; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: SOIL LEVELS; Author-Supplied Keyword: TCDD; Author-Supplied Keyword: TEQs; Number of Pages: 6p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Partin, Melissa R.
AU - Rith-Najarian, Stephen J.
AU - Slater, Jonathan S.
AU - Korn, Jane E.
AU - Cobb, Nathaniel
AU - Soler, John T.
T1 - Improving Cancer Incidence Estimates for American Indians in Minnesota.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 1999/11//
VL - 89
IS - 11
M3 - Article
SP - 1673
EP - 1677
PB - American Public Health Association
SN - 00900036
AB - Objectives. The purpose of this study was to estimate cancer incidence for American Indians in Minnesota. Methods. Indian Health Service enrollment data were linked to the Minnesota tumor registry to identify cancers among American Indians in Minnesota. Incidence rates for the 5 most common cancers in this population, estimated after the linkage, were compared with rates estimated before the linkage and with rates for the total population of Minnesota. Results. The linkage identified 302 cancer cases not previously identified as occurring among American Indians in Minnesota. Postlinkage estimates suggested that incidence rates for prostate and colorectal cancer are similar to those for the total population of Minnesota, but that rates of lung and cervical cancer are significantly higher. Breast cancer rates are slightly lower than those for the total population of Minnesota but more than twice as high as previous estimates for American Indians. Conclusions. The postlinkage estimates suggest different priorities for cancer education, prevention, and control than might be assumed from either prelinkage estimates or previously published data, and underscore the importance offing accurate and specific data for setting these priorities. (Am J Public Health. 1999;89:1673-1677) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - INDIGENOUS peoples of the Americas
KW - HEALTH
KW - MINNESOTA
KW - UNITED States
N1 - Accession Number: 2456250; Partin, Melissa R. 1,2; Email Address: melissa.partin@med.va.gov Rith-Najarian, Stephen J. 3 Slater, Jonathan S. 1 Korn, Jane E. 1 Cobb, Nathaniel 4 Soler, John T. 1; Affiliation: 1: Minnesota Department of Health, Minneapolis 2: Minneapolis VA Medical Center 3: Indian Health Service, Albuquerque, NM. 4: Indian Health Service, Bemidji, Minn.; Source Info: Nov99, Vol. 89 Issue 11, p1673; Subject Term: CANCER; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: HEALTH; Subject Term: MINNESOTA; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article; Full Text Word Count: 4291
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DB - aph
ER -
TY - GEN
AU - Shalala, Donna E.
T1 - The 1997-1998 Fedele F. and Iris M. Fauri Memorial Lecture.
JO - Research on Social Work Practice
JF - Research on Social Work Practice
Y1 - 1999/11//
VL - 9
IS - 6
M3 - Speech
SP - 708
EP - 715
SN - 10497315
AB - The article presents the text of the lecture given by Donna E. Shalala, U.S. Secretary for Health and Human Services, at the Power Center for Performing Arts at the University of Michigan, Ann Arbor, Michigan, on September 18, 1997, about the legacy of researchers Fedele F. and Iris Fauri. As the former chancellor of the University of Wisconsin, there is one story about Fedele that Shalala particularly cherish. Apparently, Fedele sometimes joked that salary raises for faculty should be based, at least in small part, on how many children the particular faculty member had to support. Fedele spent so much of his life giving a voice in Washington to the powerless and training a powerful generation of social workers--a profession that will next year celebrate its centennial. The legacy of Fedele and Iris Fauri continues in the scholarly work of institution's faculty-and in the commitment of its graduates to rewrite the fate of poor children. Shalala said that despite her training as an academic and her deep respect for cutting-edge research and scholarship, this will not be a lecture that surveys the latest theories about child welfare and child development.
KW - CHILDREN -- United States
KW - ANN Arbor (Mich.)
KW - MICHIGAN
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
KW - UNIVERSITY of Michigan
KW - SHALALA, Donna E., 1941-
KW - FAURI, Fedele
N1 - Accession Number: 2413017; Shalala, Donna E. 1; Affiliation: 1: US. Secretary for Health and Human Services.; Source Info: Nov99, Vol. 9 Issue 6, p708; Subject Term: CHILDREN -- United States; Subject Term: ANN Arbor (Mich.); Subject Term: MICHIGAN; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services Company/Entity: UNIVERSITY of Michigan; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: SHALALA, Donna E., 1941-; People: FAURI, Fedele; Number of Pages: 8p; Document Type: Speech; Full Text Word Count: 3827
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ostrowski, S.R.
AU - Wilbur, S.
AU - Chou, C-H.S.J.
AU - Pohl, H.R.
AU - Stevens, Y-W.
AU - Allred, P.M.
AU - Roney, N.
AU - Fay, M.
AU - Tylenda, C.A.
T1 - Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/11//
VL - 15
IS - 7
M3 - Article
SP - 602
EP - 644
PB - Sage Publications, Ltd.
SN - 07482337
AB - In support of Superfund re-authorization legislation, the Division of Toxicology of the Agency for Toxic Substances and Disease Registry (ATSDR) prepared a chemical-specific consultation document for Congress that identified those chemicals with carcinogenic, neurological, or developmental adverse effects having a latency period longer than 6 years. The review was limited to the top 50 substances listed on ATSDR's 1997 Priority List of Hazardous Substances (Priority List). Among the top 50 chemicals, a review of the technical literature indicated that 38 (76%) were classified as “reasonably anticipated,” “possibly,” or “probably” capable of causing cancer in humans, based either on human and animal data. Eight chemicals (16%) had well-established cancer latency periods in humans of 6 years or more following exposure. Three substances (6%)—arsenic, creosote, and benzidine—had data indicating latency periods longer than 6 years. The technical literature review likewise confirmed the potential for neurological and developmental effects with a latency of 6 years. Twenty-seven (54%) of the top 50 substances caused acute and/or chronic neurotoxic effects; a number of these also caused neurological effects that persisted beyond 6 years (or the equivalent in animal studies) such as: behavioral problems, neurological deficiencies, reduced psychomotor development, cognitive deficiencies, and reduced IQ. Twenty-eight substances (56%) caused adverse developmental effects in offspring of exposed individuals or animals including increased fetal and infant mortality, decreased birth weights and litter sizes, and growth delays. Latency periods for related chemicals are expected to be similar due to structural and toxicological similarities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAZARDOUS substances
KW - CARCINOGENESIS
KW - VINYL chloride
KW - PHYSIOLOGY
N1 - Accession Number: 4745658; Ostrowski, S.R. 1 Wilbur, S. 1 Chou, C-H.S.J. 1 Pohl, H.R. 1 Stevens, Y-W. 1 Allred, P.M. 1 Roney, N. 1 Fay, M. 1 Tylenda, C.A. 1; Affiliation: 1: Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia; Source Info: 1999, Vol. 15 Issue 7, p602; Subject Term: HAZARDOUS substances; Subject Term: CARCINOGENESIS; Subject Term: VINYL chloride; Subject Term: PHYSIOLOGY; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 43p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eisenberg, John M.
AU - Eisenberg, J M
T1 - Ten lessons for evidence-based technology assessment.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 1999/11/17/
VL - 282
IS - 19
M3 - journal article
SP - 1865
EP - 1869
SN - 00987484
AB - Suggests guidelines for the assessment of technological advances in the medical field. Need for innovation and flexibility in these assessments; Roles of research and cost; Importance of frequent re-evaulation of quickly changing technology.
KW - MEDICAL innovations
KW - TECHNOLOGY
KW - MEDICAL technology
KW - TECHNOLOGICAL innovations
KW - ALTERNATIVE medicine
KW - COMMUNICATION
KW - FEDERAL government
KW - INTERNATIONAL relations
KW - QUALITY assurance
KW - RISK assessment
KW - EVIDENCE-based medicine
N1 - Accession Number: 2485891; Eisenberg, John M. Eisenberg, J M 1; Affiliation: 1: Office of Health Care Information, Agency for Health Care Policy and Research, US Department of Health and Human Services, Rockville, MD 20852, USA; Source Info: 11/17/99, Vol. 282 Issue 19, p1865; Subject Term: MEDICAL innovations; Subject Term: TECHNOLOGY; Subject Term: MEDICAL technology; Subject Term: TECHNOLOGICAL innovations; Subject Term: ALTERNATIVE medicine; Subject Term: COMMUNICATION; Subject Term: FEDERAL government; Subject Term: INTERNATIONAL relations; Subject Term: QUALITY assurance; Subject Term: RISK assessment; Subject Term: EVIDENCE-based medicine; NAICS/Industry Codes: 911410 Foreign affairs; NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 5p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aoki, I.
AU - Itoh, S.
AU - Yokota, S.
AU - Tanaka, S.‐I.
AU - Ishii, N.
AU - Okuda, K.
AU - Minami, M.
AU - Klinman, D. M.
T1 - Contribution of mast cells to the T helper 2 response induced by simultaneous subcutaneous and oral immunization.
JO - Immunology
JF - Immunology
Y1 - 1999/12//
VL - 98
IS - 4
M3 - Article
SP - 519
EP - 524
PB - Wiley-Blackwell
SN - 00192805
AB - Summary This work examines the contribution of mast cells to the synergistic enhancement of the T helper 2 (Th2) immune response elicited following simultaneous oral and subcutaneous (s.c.) immunization. The s.c. route induced a Th1‐biased immune response, characterized by increased interferon‐γ (IFN‐γ) and immunoglobulin G2a (IgG2a) antibody production. In contrast, oral immunization stimulated a primarily Th2‐type response in which interleukin‐4 (IL‐4) and IgG1 antibody production were dominant. Simultaneous immunization also triggered a Th2‐biased response, the magnitude of which exceeded the additive effects of s.c. and oral immunization alone by greater than threefold. To analyse whether mast cells in gut‐associated lymphoid tissue contributed to this synergistic response, mast cell‐deficient mice WBB6F1 ‐w/wv were studied. Whereas the primary response following simultaneously antigen administration was reduced only twofold in these animals compared with wild type controls WBB6F1 ‐ +/+ (suggesting that mast cells were not needed to initiate Th2 immunity), reconstitution with bone‐marrow‐derived mast cells from WBB6F1 ‐+/+ mice resulted in a superoptimal response (suggesting that mast cells contribute to the magnitude and perpetuation of these Th2‐biased responses). [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAST cells
KW - IMMUNE response
KW - T cells
KW - IMMUNIZATION
N1 - Accession Number: 5605297; Aoki, I. 1 Itoh, S. 2 Yokota, S. 2 Tanaka, S.‐I. 3 Ishii, N. 4 Okuda, K. 5 Minami, M. 6 Klinman, D. M. 7; Affiliation: 1: Pathology, 2: Pediatrics, 3: Internal Medicine, 4: Dermatology, 5: Bacteriology and 6: Parasitology, Yokohama City University School of Medicine, Yokohama, Japan, and 7: Section of Retroviral Immunology, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda MD, USA; Source Info: Dec99, Vol. 98 Issue 4, p519; Subject Term: MAST cells; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: IMMUNIZATION; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2567.1999.00878.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alexander, Greg R.
AU - Kogan, Michael D.
AU - Himes, John H.
T1 - 1994–1996 U.S. Singleton Birth Weight Percentiles for Gestational Age by Race, Hispanic Origin, and Gender.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 1999/12//
VL - 3
IS - 4
M3 - Article
SP - 225
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives: Establishing and comparing race, ethnic, and gender-specific birth weight percentiles for gestational age is requisite for investigating the determinants of variations in fetal growth. In this study, we calculate percentiles of birth weight for gestational age for the total 1994–1996 U.S. population and contrast these percentiles by racial/ethnic and gender groups. Methods: Single live births to U.S. resident mothers were selected from the 1994–1996 U.S. Natality Files. After exclusions, 5,973,440 non-Hispanic Whites, 1,393,908 non-Hispanic African Americans, 1,683,333 Hispanics, 80,187 Native Americans, and 510,021 other racial/ethnic groups were used to calculate distribution percentiles of birth weight for each gestational age for which there were at least 50 cases to calculate the 50th percentile and 100 cases to calculate the 10th percentile. Results: Fetal growth patterns among the four U.S. racial/ethnic groups varied markedly and, across the gestational age range, there was considerable oscillation in the relative ranking of any one group's birth weight percentile value in comparison to the others. Males had relatively higher birth weight percentile values than females. The proportion of infants with a birth weight value less than 1994–1996 U.S. population's 10th percentile value of birth weight for their corresponding gestational age was 7.87 for non-Hispanic Whites, 15.43 for non-Hispanic African Americans, 9.30 for Hispanics, and 8.81 for Native Americans. Conclusions: While the factors underlying trends and population subgroup differences in fetal growth are unclear, nutrition, smoking habits, health status, and maternal morbidity are possible precursors for part of the variations in patterns of fetal growth. As prenatal care has been touted as a means to reduce the risk of fetal growth restriction at term, assuring the availability and accessibility of comprehensive prenatal care services is viewed as an essential corollary in the effort to improve fetal growth patterns in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIRTH weight
KW - GESTATIONAL age
KW - FETAL development
KW - ETHNIC groups
KW - UNITED States
KW - Birth weight
KW - ethnicity, Hispanic
KW - fetal growth restriction
KW - gender, race
KW - gestational age
KW - large-for-gestational age
KW - small-for-gestational age
N1 - Accession Number: 11307806; Alexander, Greg R. 1; Email Address: greg.alexander@uab.edu Kogan, Michael D. 2 Himes, John H. 3; Affiliation: 1: School of Public Health, Department of Maternal and Child Health, University of Alabama at Birmingham, Alabama 2: Office of Data and Information Management, Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland 3: School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota; Source Info: Dec1999, Vol. 3 Issue 4, p225; Subject Term: BIRTH weight; Subject Term: GESTATIONAL age; Subject Term: FETAL development; Subject Term: ETHNIC groups; Subject Term: UNITED States; Author-Supplied Keyword: Birth weight; Author-Supplied Keyword: ethnicity, Hispanic; Author-Supplied Keyword: fetal growth restriction; Author-Supplied Keyword: gender, race; Author-Supplied Keyword: gestational age; Author-Supplied Keyword: large-for-gestational age; Author-Supplied Keyword: small-for-gestational age; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lehman, Anthony F.
T1 - Improving Treatment for Persons with Schizophrenia.
JO - Psychiatric Quarterly
JF - Psychiatric Quarterly
Y1 - 1999/12//
VL - 70
IS - 4
M3 - Article
SP - 259
EP - 272
PB - Springer Science & Business Media B.V.
SN - 00332720
AB - The time has come for the development of standards to ensure quality and cost-effective care for the treatment of persons with schizophrenia. Advances in understanding the efficacy of treatments for schizophrenia, the promise of new treatment advances derived from a rapidly evolving neuroscience, pressures to contain health care costs while maintaining or increasing quality, and the growth of advocacy on behalf of persons with schizophrenia are driving this need. The evidence for the efficacy of pharmacotherapies, psychological interventions, family interventions, vocational rehabilitation, and case management and assertive community treatment is substantial, yet many patients do not receive treatments consistent with this evidence. Service systems must do much more to ensure that efficacious treatments are available, that both effectiveness and costs are considered in the allocation of resources, and that evaluative systems are in place to promote on-going quality improvement to provide the best care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychiatric Quarterly is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHIZOPHRENIA -- Treatment
KW - PSYCHOSES -- Treatment
KW - PSYCHOTHERAPY
KW - MENTAL health
N1 - Accession Number: 11303834; Lehman, Anthony F. 1; Email Address: alehman@umpsy.umaryland.edu; Affiliation: 1: University of Maryland, Center for Mental Health Services Research; Source Info: Dec1999, Vol. 70 Issue 4, p259; Subject Term: SCHIZOPHRENIA -- Treatment; Subject Term: PSYCHOSES -- Treatment; Subject Term: PSYCHOTHERAPY; Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fay, M.
AU - Donohue, J.M.
AU - de Rosa, C.
T1 - Atsdr Evaluation of Health Effects of Chemicals. Vi. Di(2-Ethylhexyl)phthalate.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 1999/12//
VL - 15
IS - 8
M3 - Article
SP - 651
EP - 746
PB - Sage Publications, Ltd.
SN - 07482337
AB - Di(2-ethylhexyl)phthalate (also known as DEHP, bis(2-ethylhexyl)phthalate, or BEHP; CAS Registry Number 117-81-7) is a widely-used plasticizer. It is found in numerous plastic articles, such as paints, inks, floor tiles, upholstery, shower curtains, footwear, plastic bags, food-packaging materials, toys, and medical tubing. Not surprisingly, DEHP appears at many waste sites. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals that are of greatest public health concern at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priority List (NPL) sites. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of ATSDR's profile for DEHP (ATSDR, 1993) into the mainstream scientific literature. An extensive listing of human and animal health effects, organized by route, duration, and endpoint, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, at the behest of Congress and therefore the citizenry, prepares these profiles to inform the public about site contaminants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHTHALATE esters
KW - TOXICOLOGY
KW - PUBLIC health
KW - PLASTICS
KW - ATSDR
KW - BEHP
KW - Bis(2-ethylhexyl)phthalate
KW - CAS 117-81-7
KW - DEHP
KW - Di(2-ethylhexyl)phthalate
KW - environmental fate
KW - exposure
KW - Health effects
KW - review
KW - toxicokinetics
N1 - Accession Number: 4745629; Fay, M. 1 Donohue, J.M. 2 de Rosa, C. 1; Affiliation: 1: U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, Georgia 2: U.S. Environmental Protection Agency, Office of Water, Washington, D.C.; Source Info: 1999, Vol. 15 Issue 8, p651; Subject Term: PHTHALATE esters; Subject Term: TOXICOLOGY; Subject Term: PUBLIC health; Subject Term: PLASTICS; Author-Supplied Keyword: ATSDR; Author-Supplied Keyword: BEHP; Author-Supplied Keyword: Bis(2-ethylhexyl)phthalate; Author-Supplied Keyword: CAS 117-81-7; Author-Supplied Keyword: DEHP; Author-Supplied Keyword: Di(2-ethylhexyl)phthalate; Author-Supplied Keyword: environmental fate; Author-Supplied Keyword: exposure; Author-Supplied Keyword: Health effects; Author-Supplied Keyword: review; Author-Supplied Keyword: toxicokinetics; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 326198 All other plastic product manufacturing; NAICS/Industry Codes: 326121 Unlaminated Plastics Profile Shape Manufacturing; NAICS/Industry Codes: 325211 Plastics Material and Resin Manufacturing; NAICS/Industry Codes: 424610 Plastics Materials and Basic Forms and Shapes Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 96p; Illustrations: 1 Black and White Photograph, 13 Diagrams, 14 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoff, P.M.
AU - Lassere, Y.
AU - Pazdur, R.
T1 - Tegafur/Uracil + Calcium Folinate in Colorectal Cancer: Double Modulation of Fluorouracil.
JO - Drugs
JF - Drugs
Y1 - 1999/12/04/Dec1999 Supplement 3
VL - 58
IS - 6
M3 - Article
SP - 77
EP - 83
PB - Springer Science & Business Media B.V.
SN - 00126667
AB - The oral chemotherapeutic agent tegafur/uracil (UFT) is the first of a new class of anticancer drugs called dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines. Tegafur/uracil combines uracil with the fluorouracil prodrug tegafur in a 4:1 molar ratio. Uracil competitively inhibits the degradation of fluorouracil, which results in the concentration of fluorouracil remaining at sustained levels in both plasma and tumour. Tegafur/uracil has been commercially available in Japan since 1983 and examined extensively in various tumours. Trials conducted in the US have focused on the combination of tegafur/uracil plus calcium folinate (calcium leucovorin) [ORZEL]. Several phase I and II trials have evaluated the maximum tolerated dose, pharmacokinetics, efficacy, and safety of this combination in the treatment of colorectal cancer. Results have shown that tegafur/uracil at 300 mg/m/day in divided doses given every 8 hours for 28 days provides prolonged exposure to fluorouracil. Furthermore, tegafur/uracil + calcium folinate is well tolerated, with dose-limiting toxicity manifesting as diarrhoea. Compared with intravenous fluorouracil plus folinic acid (leucovorin) regimens, tegafur/uracil + calcium folinate has similar efficacy with less toxicity and is more convenient because it is an oral regimen. Early studies have also shown potential cost savings because of fewer complications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer
KW - URACIL
KW - DRUG therapy
KW - ORAL medication
KW - ANTINEOPLASTIC agents
KW - Antineoplastics, therapeutic use
KW - Colorectal cancer, treatment
KW - Folinic acid, therapeutic use
KW - Maximum tolerated dose
KW - Oral
KW - Reviews on treatment
KW - Tegafur/uracil, pharmacodynamics
KW - Tegafur/uracil, pharmacokinetics
KW - Tegafur/uracil, therapeutic use
N1 - Accession Number: 9593660; Hoff, P.M. 1 Lassere, Y. 1 Pazdur, R. 2; Affiliation: 1: Department of Gastrointestinal Medical Oncology and Digestive Diseases, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA 2: Food and Drug Administration, Division of Oncology Drug Products, Rockville, Maryland, USA; Source Info: Dec1999 Supplement 3, Vol. 58 Issue 6, p77; Subject Term: COLON cancer; Subject Term: URACIL; Subject Term: DRUG therapy; Subject Term: ORAL medication; Subject Term: ANTINEOPLASTIC agents; Author-Supplied Keyword: Antineoplastics, therapeutic use; Author-Supplied Keyword: Colorectal cancer, treatment; Author-Supplied Keyword: Folinic acid, therapeutic use; Author-Supplied Keyword: Maximum tolerated dose; Author-Supplied Keyword: Oral; Author-Supplied Keyword: Reviews on treatment; Author-Supplied Keyword: Tegafur/uracil, pharmacodynamics; Author-Supplied Keyword: Tegafur/uracil, pharmacokinetics; Author-Supplied Keyword: Tegafur/uracil, therapeutic use; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McMillen, J. Curtis
AU - North, Carol S.
AU - Smith, Elizabeth M.
T1 - What Parts of PTSD Are Normal: Intrusion, Avoidance, or Arousal? Data from the Northridge, California, Earthquake.
JO - Journal of Traumatic Stress
JF - Journal of Traumatic Stress
Y1 - 2000/01//
VL - 13
IS - 1
M3 - Article
SP - 57
PB - John Wiley & Sons, Inc.
SN - 08949867
AB - The incidence and comorbidity of posttraumatic stress disorder (PTSD) are addressed in a study of 130 Northridge, California, earthquake survivors interviewed 3 months postdisaster. Only 13% of the sample met full PTSD criteria, but 48% met both the reexperiencing and the arousal symptom criteria, without meeting the avoidance and numbing symptom criterion. Psychiatric comorbidity was associated mostly with avoidance and numbing symptoms. For moderately severe traumatic events, reexperiencing and arousal symptoms may be the most “normal,” and survivors with a history of psychiatric problems may be those most likely to develop full PTSD. A system that considers people who meet all three symptom criteria to have a psychiatric disorder yet recognizes the distress of other symptomatic survivors may best serve traumatized populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Traumatic Stress is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POST-traumatic stress disorder
KW - TRAUMATIC neuroses
KW - DISASTER victims
KW - MENTAL illness
KW - EARTHQUAKES
KW - COMORBIDITY
KW - PATHOLOGICAL psychology
KW - PSYCHOLOGICAL aspects
KW - CALIFORNIA
KW - UNITED States
KW - comorbidity
KW - comorbidity.
KW - disaster
KW - PTSD
KW - symptom criteria
N1 - Accession Number: 11308610; McMillen, J. Curtis 1 North, Carol S. 2 Smith, Elizabeth M. 2; Affiliation: 1: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St.. Louis. Campus Box 1196, St. Louis, Missouri 63130. 2: Department of Psychiatry, School of Medicine, Washington University, St. Louis.; Source Info: Jan2000, Vol. 13 Issue 1, p57; Subject Term: POST-traumatic stress disorder; Subject Term: TRAUMATIC neuroses; Subject Term: DISASTER victims; Subject Term: MENTAL illness; Subject Term: EARTHQUAKES; Subject Term: COMORBIDITY; Subject Term: PATHOLOGICAL psychology; Subject Term: PSYCHOLOGICAL aspects; Subject Term: CALIFORNIA; Subject Term: UNITED States; Author-Supplied Keyword: comorbidity; Author-Supplied Keyword: comorbidity.; Author-Supplied Keyword: disaster; Author-Supplied Keyword: PTSD; Author-Supplied Keyword: symptom criteria; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Aidoo, Anane
AU - Li, Jing
AU - Lyn-Cook, Lascelles E.
AU - Casciano, Daniel A.
AU - Feuers, Ritchie J.
T1 - Effects of Bleomycin on Liver Antioxidant Enzymes and the Electron Transport System From Ad Libitum-Fed and Dietary-Restricted Female and Male Fischer 344 Rats.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2000/01//
VL - 36
IS - 1
M3 - Article
SP - 42
EP - 51
PB - Taylor & Francis Ltd
SN - 01635581
AB - Dietary restriction (DR) is the only known intervention that delays aging and age-related diseases. Mechanisms proposed to explain this DR effect include a decline in free radical production and an increase in free radical detoxification. In the present study the effect of bleomycin (BLM) as a reactive oxygen species-generating antitumor drug has been evaluated on antioxidant enzymes and the electron transport system in different cellular fractions of liver in female and male Fischer 344 rats. Animals were fed ad libitum (AL) or 60% of the AL intake (DR) and were given a single intraperitoneal injection of 2.5, 5, or 10 mg BLM/kg body wt. After four weeks, BLM significantly increased glutathione peroxidase and lactate dehydrogenase activities in liver cytosol of female AL rats and increased activity even more in male rats. Similar changes were also noted for glutathione reductase and glucose 6-phosphate dehydrogenase activities in BLM-treated AL rats. In liver mitochondria, glutathione peroxidase was increased in female and male AL rats but was increased more in female rats. Drug treatment had no significant effect on these enzyme activities in cytosolic or mitochondrial fractions of DR animals. Profound effects of BLM were noted in activities of complexes I, III, and IV of the electron transport system in AL and DR female and male rats; however, complex II demonstrated no significant diet or treatment effect. Induced antioxidant enzyme activities in BLM-treated AL rats may be a response to excessive free radical generation due to BLM metabolism in AL animals that is mitigated by DR. Furthermore, dysfunction of the electron transport system might suggest its role in a secondary generation of free radicals during BLM metabolism contributing to its toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLEOMYCIN
KW - ELECTRON transport
KW - ACTIVE oxygen
KW - FREE radical reactions
N1 - Accession Number: 3364867; Desai, Varsha G. 1 Aidoo, Anane 1 Li, Jing 1 Lyn-Cook, Lascelles E. 1 Casciano, Daniel A. 1 Feuers, Ritchie J. 1; Affiliation: 1: National Center for Toxicological Research, Food and Drug Administration, Department of Health and Human Services; Source Info: 2000, Vol. 36 Issue 1, p42; Subject Term: BLEOMYCIN; Subject Term: ELECTRON transport; Subject Term: ACTIVE oxygen; Subject Term: FREE radical reactions; Number of Pages: 10p; Illustrations: 6 Graphs; Document Type: Article; Full Text Word Count: 5310
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tripi, Paul A.
AU - Modlin, Sheryl
AU - Sorenson, W.G.
AU - Dearborn, Dorr G.
T1 - Acute pulmonary haemorrhage in an infant during induction of general anaesthesia.
JO - Paediatric Anaesthesia
JF - Paediatric Anaesthesia
Y1 - 2000/01//
VL - 10
IS - 1
M3 - Article
SP - 92
EP - 94
PB - Wiley-Blackwell
SN - 11555645
AB - SummaryPulmonary haemorrhage is a rare, life-threatening complication of anaesthesia. This report describes the anaesthetic management of an infant who developed laryngospasm and pulmonary haemorrhage during general anaesthesia. The infant was subsequently found to have prior exposure to a fungus, Stachybotrys chartarum, which produces mycotoxins that may have produced capillary fragility in the infant's rapidly growing lungs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric Anaesthesia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRIC anesthesia
KW - HEMORRHAGIC diseases in children
KW - LUNG diseases
KW - anaesthesia
KW - laryngospasm
KW - Pulmonary haemorrhage
KW - Stachybotrys chartarum
N1 - Accession Number: 6083165; Tripi, Paul A. 1 Modlin, Sheryl 1 Sorenson, W.G. 2 Dearborn, Dorr G. 3; Affiliation: 1: Division of Pediatric Anesthesiology, Rainbow Babies and Childrens Hospital, University Hospitals of Cleveland, Cleveland, Ohio, Case Western Reserve University, Cleveland, Ohio 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Division of Pediatric Pulmonary Disease, Rainbow Babies and Childrens Hospital, University Hospitals of Cleveland, Cleveland, Ohio, Case Western Reserve University, Cleveland, Ohio; Source Info: Jan2000, Vol. 10 Issue 1, p92; Subject Term: PEDIATRIC anesthesia; Subject Term: HEMORRHAGIC diseases in children; Subject Term: LUNG diseases; Author-Supplied Keyword: anaesthesia; Author-Supplied Keyword: laryngospasm; Author-Supplied Keyword: Pulmonary haemorrhage; Author-Supplied Keyword: Stachybotrys chartarum; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1460-9592.2000.00452.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Castranova, Vincent
T1 - From Coal Mine Dust To Quartz: Mechanisms of Pulmonary Pathogenicity.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 7
EP - 14
PB - Taylor & Francis Ltd
SN - 08958378
AB - Exposure to coal mine dust or crystalline silica can result in the initiation and progression of interstitial lung disease. Pathogenesis is the consequence of damage to lung cells and resulting lung scarring associated with activation of fibrotic processes. This review presents the radiologic and histologic characteristics of simple and complicated coal workers’ pneumoconiosis (CWP) as well as pathological indices of acute and chronic silicosis. This presentation also reviews the results of in vitro, animal, and human investigations that elucidate mechanisms involved in the development of these pneumoconioses. Results support the involvement of four basic mechanisms in the etiology of CWP and silicosis:1. Direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring.2. Activation of oxidant production by pulmonary phagocytes, such as alveolar macrophages. When oxidant production exceeds antioxidant defenses, lipid peroxidation and protein nitrosation occur, resulting in tissue injury and consequent scarring.3. Activation of mediator release from alveolar macrophages and alveolar epithelial cells. Chemokines recruit polymorphonuclear leukocytes and macrophages from the pulmonary capillaries into the air spaces. Once within the air spaces, these leukocytes are activated by proinflammatory cytokines to produce reactive species, which increase oxidant injury and lung scarring.4. Secretion of growth factors from alveolar macrophages and alveolar epithelial cells. Release of such mediators stimulates fibroblast proliferation and induces fibrosis. In conclusion, results of in vitro and animal studies have provided the basis for proposing mechanisms that may lead to the initiation and progression of CWP and silicosis. Data obtained from exposed workers has lent support to these proposals. The mechanistic understanding obtained for the development of CWP and silicosis should be useful in elucidating the possible pathogenicity of other inhaled particles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINERAL dusts
KW - VIRULENCE (Microbiology)
KW - OXIDE minerals
KW - AIR pollutants
KW - FOSSIL fuels
N1 - Accession Number: 121039260; Castranova, Vincent 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2000 Supplement 3, Vol. 12, p7; Subject Term: MINERAL dusts; Subject Term: VIRULENCE (Microbiology); Subject Term: OXIDE minerals; Subject Term: AIR pollutants; Subject Term: FOSSIL fuels; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/08958378.2000.11463226
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vallyathan, Val
AU - Ding, Min
AU - Shi, Xianglin
AU - Castranova, Vincent
T1 - Molecular Activation of Activator Protein-1 In Silica and Asbestos-Induced Carcinogenesis.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 353
EP - 357
PB - Taylor & Francis Ltd
SN - 08958378
AB - Occupational exposures to asbestos and crystalline silica have been implicated in causing lung cancer and other pulmonary diseases in humans. Despite intensive research during the last decade on pulmonary carcinogenesis induced by these minerals, the exact molecular mechanisms involved in carcinogenesis are still unknown. Chronic inflammation and enhanced production of reactive oxygen species (ROS) generated by these particulates have been implicated in the development of tumors. In an attempt to understand the molecular basis of carcinogenesis induced by these particles, we investigated the potential activation of activator protein-1 (AP-1) by crocidolite and freshly fractured or aged crystalline silica in a JB6 P+cell line stably transfected with AP-1-luciferase reporter plasmid (in vitro) and in AP-1-luciferase reporter transgenic mice (in vivo). This transcription factor governs the expression of target genes that are involved in encoding cytokines, chemokines, growth factors, cell adhesion molecules, and acute-phase proteins that regulate inflammation, cell proliferation, and apoptosis. Results of our studies suggest that asbestos and silica activate AP-1 through generation of ROS. In in vitro studies, crocidolite asbestos caused a dose- and time-dependent AP-1 activation in JB6+ cells, which persisted for at least 72 h. In transgenic mice exposed to crocidolite asbestos, AP-1 activation increased significantly by 10-fold in lung tissue and 22-fold in bronchial tissue. This induction of AP-1 activation by crocidolite appears to be mediated through the influence of mitogen-activated protein kinase (MAPK) family members, specifically extracellular signal-regulating protein kinase, ERK 1, and ERK 2 (data not presented). Similarly, freshly fractured silica caused an 8-fold increase in AP-1 activation in JB6 P+cells and 22-fold increase in transgenic mice. The activation of AP-1 by freshly fractured silica was mediated through ERK1, ERK2, and p38 kinase. Activation of AP-1 by asbestos or silica was inhibited in both in vitro and in vivo systems by aspirin, which exhibits OH radical scavenging properties. It is proposed from these studies that asbestos and crystalline silica may promote carcinogenesis through specific mechanistic pathways stimulated by ROS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICON compounds
KW - AP-1 transcription factor
KW - HEAT resistant materials
KW - CARCINOGENESIS
KW - GENETIC toxicology
N1 - Accession Number: 121039279; Vallyathan, Val 1 Ding, Min 1 Shi, Xianglin 1 Castranova, Vincent 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2000 Supplement 3, Vol. 12, p353; Subject Term: SILICON compounds; Subject Term: AP-1 transcription factor; Subject Term: HEAT resistant materials; Subject Term: CARCINOGENESIS; Subject Term: GENETIC toxicology; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/08958378.2000.11463245
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kuempel, Eileen D.
AU - Tran, Chi-Lang
AU - O’Flaherty, Ellen J.
AU - Stayner, Leslie T.
AU - Smith, Randall J.
AU - Dankovic, David A.
AU - Bailer, John A.
T1 - Evaluation of Particle Clearance and Retention Kinetics in the Lungs of U.S. Coal Miners.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/01/04/2000 Supplement 3
VL - 12
M3 - Article
SP - 397
EP - 402
PB - Taylor & Francis Ltd
SN - 08958378
AB - Rodent studies are frequently used to assess risk in humans, yet it is not known whether the overloading of lung clearance, as observed in rodents, occurs in humans, or whether overloading is related to particle-related lung diseases in humans. The objective of this study is to develop a biologically based mathematical model to describe the retention and clearance of respirable coal mine dust in the lungs of humans. A human dosimetric lung model was developed that includes alveolar, interstitial, and hilar lymph-node compartments. The model describes the particle mass transfer kinetics among these compartments and clearance via the tracheobronchi. The model was calibrated using data in U.S. coal miners, including individual working lifetime exposure histories and lung and lymph-node particle burdens. The model fit to the human data was evaluated using a least-squared error criterion. The end-of-life lung dust burdens of all coal miners in this study were substantially greater than expected from a simple, linear first-order model with effective clearance, yet their lung and lymph-node dust burdens were lower than expected from the rodent-based overload model, particularly at higher exposures. The best fitting model included a predominant first-order interstitial compartment, in which the particles are essentially sequestered (with very slow clearance to the lymph nodes), and a first-order alveolar clearance compartment with either no dose-dependent decline (overloading) or much less than expected from the rodent studies. These findings are consistent with the findings from magnetopneumography studies of clearance in retired miners and from studies of particle retention patterns in rodents and primates. This human dosimetric lung model is useful for evaluating the kinetic differences of particle retention in humans and rodents, and for evaluating the lung closes in humans given different exposure scenarios. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL miners -- United States
KW - COAL miners
KW - DISEASES
KW - LUNG diseases
KW - PATIENTS
KW - COAL dust
KW - LYMPH nodes
N1 - Accession Number: 121039285; Kuempel, Eileen D. 1 Tran, Chi-Lang 2 O’Flaherty, Ellen J. 3 Stayner, Leslie T. 1 Smith, Randall J. 1 Dankovic, David A. 1 Bailer, John A. 1,4; Affiliation: 1: National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, Ohio, USA 2: Institute for Occupational Medicine, Edinburgh, Scotland, United Kingdom 3: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA 4: Miami University, Oxford, Ohio, USA; Source Info: 2000 Supplement 3, Vol. 12, p397; Subject Term: COAL miners -- United States; Subject Term: COAL miners; Subject Term: DISEASES; Subject Term: LUNG diseases; Subject Term: PATIENTS; Subject Term: COAL dust; Subject Term: LYMPH nodes; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/08958378.2000.11463251
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mukwaya, L. G.
AU - Kayondo, J. K.
AU - Crabtree, M. B.
AU - Savage, H. M.
AU - Biggerstaff, B. J.
AU - Miller, B. R.
T1 - Genetic differentiation in the yellow fever virus vector, Aedes simpsoni complex, in Africa: Sequence variation in the ribosomal DNA internal transcribed spacers of anthropophilic and non-anthropophilic populations.
JO - Insect Molecular Biology
JF - Insect Molecular Biology
Y1 - 2000/02//
VL - 9
IS - 1
M3 - Article
SP - 85
EP - 91
PB - Wiley-Blackwell
SN - 09621075
AB - AbstractMosquitoes of the Aedes simpsoni complex are important vectors of yellow fever virus in Africa. We examined the ribosomal DNA sequence divergence in the internal transcribed spacer regions (ITS-1 and ITS-2) for populations of mosquitoes that were determined to be anthropophilic or non-anthropophilic in their bloodmeal host preference. A neighbour-joining tree produced two clades: one contained all of the individual mosquitoes from anthropophilic populations and the other contained all of the individual mosquitoes from non-anthropophilic populations. There was no segregation of the taxa within each of the two clades based on geographical origin. The data suggest the exisf′tence of two distinct species of Ae. simpsoni s.l. in Uganda that correlates with their host blood-feeding preference. The current taxonomic status of the complex is discussed in relation to these findings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Insect Molecular Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOSQUITOES
KW - NUCLEOTIDE sequence
KW - GENETICS
KW - Aedes bromeliae
KW - Aedes lilii
KW - Aedes simpsoni
KW - anthropophily
KW - ribosomal DNA
KW - Yellow fever
N1 - Accession Number: 5609189; Mukwaya, L. G. 1 Kayondo, J. K. 1 Crabtree, M. B. 2 Savage, H. M. 2 Biggerstaff, B. J. 2 Miller, B. R. 2; Affiliation: 1: Department of Entomology, Uganda Virus Research Institute, Entebbe, and 2: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO, USA; Source Info: Feb2000, Vol. 9 Issue 1, p85; Subject Term: MOSQUITOES; Subject Term: NUCLEOTIDE sequence; Subject Term: GENETICS; Author-Supplied Keyword: Aedes bromeliae; Author-Supplied Keyword: Aedes lilii; Author-Supplied Keyword: Aedes simpsoni; Author-Supplied Keyword: anthropophily; Author-Supplied Keyword: ribosomal DNA; Author-Supplied Keyword: Yellow fever; Number of Pages: 7p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1046/j.1365-2583.2000.00161.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chin, Marshall H.
AU - Auerbach, Steven B.
AU - Cook, Sandy
AU - Harrison, James F.
AU - Koppert, Julie
AU - Lei Jin
AU - Thiel, Fay
AU - Karrison, Theodore G.
AU - Harrand, Anita G.
AU - Schaefer, Cynthia T.
AU - Takashima, Herbert T.
AU - Egbert, Nancy
AU - Sin-Ching Chiu
AU - McNabb, Wylie L.
T1 - Quality of Diabetes Care in Community Health Centers.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/03//
VL - 90
IS - 3
M3 - Article
SP - 431
EP - 434
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study assessed the quality of diabetes care in community health centers. Methods. In 55 midwestern community health centers, we reviewed the charts of 2865 diabetic adults for American Diabetes Association measures of quality. Results. On average, 70% of the patients in each community health center had measurements of glycosylated hemoglobin, 26% had dilated eye examinations, 66% had diet intervention, and 51% received foot care. The average glycosylated hemoglobin value per community health center was 8.6%. Practice guidelines were independently associated with higher quality of care. Conclusions. Rates of adherence to process measures of quality were relatively low among community health centers, compared with the targets established by the American Diabetes Association. (Am d Public Health. 2000;90:431-434) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Quality control
KW - DIABETES
KW - MEDICAL centers
KW - COMMUNITY health services
KW - AMERICAN Diabetes Association
N1 - Accession Number: 2856541; Chin, Marshall H. 1; Email Address: mchin@medicine.bsd.uchicago.edu Auerbach, Steven B. 2 Cook, Sandy 1 Harrison, James F. 3 Koppert, Julie 4 Lei Jin 1 Thiel, Fay 4 Karrison, Theodore G. 1 Harrand, Anita G. 5 Schaefer, Cynthia T. 6 Takashima, Herbert T. 2 Egbert, Nancy 2 Sin-Ching Chiu 7 McNabb, Wylie L. 1; Affiliation: 1: Departments of Medicine and Health Studies, Diabetes Research and Training Center, University of Chicago, Ill. 2: Health Resources and Services Administration Field Offices, New York, NY; Kansas City, Mo; and Chicago, Ill. 3: North Woods Community Health Center, Minong, Wis. 4: MidWest Clinicians' Network, Inc, Kenton, Ohio, and Okemos, Mich. 5: Hamilton Family Medical Center, Flint, Mich. 6: ECHO Health Center, Evansville, Ind. 7: Family Medical Center, Temperance, Mich.; Source Info: Mar2000, Vol. 90 Issue 3, p431; Subject Term: MEDICAL care -- Quality control; Subject Term: DIABETES; Subject Term: MEDICAL centers; Subject Term: COMMUNITY health services; Company/Entity: AMERICAN Diabetes Association DUNS Number: 784510570; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article; Full Text Word Count: 2814
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gubina, E.
AU - Ruiz-Hidalgo, M.J.
AU - Baladrón, V.
AU - Laborda, J.
T1 - Assignment of dlk (Dlk1) to mouse chromosome band 12E–F1 by in situ hybridization.
JO - Cytogenetics & Cell Genetics
JF - Cytogenetics & Cell Genetics
Y1 - 2000/03//
VL - 88
IS - 3/4
M3 - Article
SP - 322
EP - 323
SN - 03010171
AB - Dlk clones from a mouse P1 genomic library were selected by using a PCR primer pair that amplifies a fragment of exon V of the dlk gene. The genomic clones identified were characterized as corresponding to mouse Dlk1 by sequencing, restriction enzyme digestions and Southern blot hybridization. Genomic fragments of around 50 kb in length were used for FISH mapping. DNA was labeled with digoxigenin dUTP by nick translation. Specific hybridization signals were detected by means of antidigoxigenin antibodies followed by counterstaining with DAPI.
KW - GENETICS
KW - HYBRIDIZATION
KW - MICE
KW - CHROMOSOMES
KW - ENZYMES
KW - GENES
N1 - Accession Number: 12184692; Gubina, E. 1 Ruiz-Hidalgo, M.J. 1 Baladrón, V. 1 Laborda, J. 1; Email Address: jlaborda@med-ab.uclm.es; Affiliation: 1: Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration Rockville MD (USA).; Source Info: Mar2000, Vol. 88 Issue 3/4, p322; Subject Term: GENETICS; Subject Term: HYBRIDIZATION; Subject Term: MICE; Subject Term: CHROMOSOMES; Subject Term: ENZYMES; Subject Term: GENES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Article
L3 - 10.1159/000015519
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schwartz, Rachel M.
AU - Muri, Janet H.
AU - Overpeck, Mary D.
AU - Pezzullo, John C.
AU - Kogan, Michael D.
T1 - Use of High-Technology Care Among Women with High-Risk Pregnancies in the United States.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2000/03//
VL - 4
IS - 1
M3 - Article
SP - 7
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objective: Infant mortality has been reduced dramatically with the development of perinatal regionalized high-technology care. Our objective was to assess use of high technology care among women with high-risk pregnancies in the urban and rural United States. Methods: The 1988 National Maternal and Infant Health Survey was linked to the 1988 American Hospital Association survey of all obstetrical hospitals. Hospitals were classified into five levels of care based on services and staffing. Women were classified as having high-risk pregnancies using two definitions: (1) gestational age <34 weeks and birthweight <1500 g (High Risk I) and (2) the first definition or an antenatal high-risk medical diagnoses (High Risk II). Analyses assessed the proportion of high-risk women delivering in appropriate locations in the rural and urban United States and explored how personal characteristics, insurance status, and use and source of prenatal care influenced where high-risk women delivered. Results: 71.2% of High Risk I and 55.9% of High Risk II women delivered in a high-technology facility (Level IIA or III). Fifty percent of HRI rural women delivered in tertiary high-technology hospitals and 39% of HRII rural women delivered in a high-technology hospital. High-risk urban women were two to three times more likely to deliver in a high-technology facility compared to their rural counterparts. The multivariate analysis showed that Black high-risk women were more likely to deliver in a high-technology setting and that receipt of prenatal care in a private setting lowered the odds of delivering in a high-technology setting when other factors were controlled. Conclusions: In an era where regionalized perinatal care was not threatened by managed care, a large proportion of high-risk women received care in less than optimal settings. Rural high-risk women delivered in high-technology hospitals less often than their urban counterparts. The multivariate analyses implied that the potential barriers to care may be more important among those considered more socially advantaged, who may be more at the mercy of managed care. The current reimbursement environment, which discourages referral to specialists and high-technology care, could result in less access today. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERNAL health services
KW - LOW birth weight
KW - PREMATURE labor
KW - INFANT mortality
KW - MEDICAL care -- United States
KW - UNITED States
KW - access
KW - high risk care
KW - levels of care
KW - low birth weight
KW - perinatal regionalization
KW - prematurely
N1 - Accession Number: 11307818; Schwartz, Rachel M. 1; Email Address: rmschwartz@aol.com Muri, Janet H. 1 Overpeck, Mary D. 2 Pezzullo, John C. 3 Kogan, Michael D. 4; Affiliation: 1: National Perinatal Information Center, Providence, Rhode Island 2: Division of Epidemiology, Statistics and Prevention Research, National Institute Child Health and Development, Bethesda, Maryland 3: Department of Pharmacology, Biomathematics adn Biostatistics, Georgetown University Medical Center, Washington, DC 4: Office of Data and Information Management, Maternal and Child Health Bureau, Rockville, Maryland; Source Info: Mar2000, Vol. 4 Issue 1, p7; Subject Term: MATERNAL health services; Subject Term: LOW birth weight; Subject Term: PREMATURE labor; Subject Term: INFANT mortality; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; Author-Supplied Keyword: access; Author-Supplied Keyword: high risk care; Author-Supplied Keyword: levels of care; Author-Supplied Keyword: low birth weight; Author-Supplied Keyword: perinatal regionalization; Author-Supplied Keyword: prematurely; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duffy, Sarah Q.
AU - Ruseski, Jane E.
AU - Cavanaugh, Sean
AU - Duffy, S Q
AU - Ruseski, J E
AU - Cavanaugh, S
T1 - Graduate medical education costs in nonacademic health center teaching hospitals: evidence from Maryland.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03//
VL - 57
IS - 1
M3 - journal article
SP - 3
EP - 23
SN - 10775587
AB - As managed care has grown, much concern has been expressed about the potential plight of the nation's 125 academic health centers (AHCs). Less concern has focused on non-AHC teaching hospitals, although most studies of graduate medical education (GME) costs include these hospitals in their estimates. While most studies have found that costs increase positively with various measures of "teaching intensity," some have concluded that hospitals with smaller programs have costs that are the same or less than comparable nonteaching hospitals. However, few studies have tested whether AHCs' cost structures are sufficiently similar to those of other hospitals to reliably include them in the same estimation. This article tests that assumption for Maryland hospitals, finds it violated, and presents results for non-AHC teaching hospitals. The results reveal that, at least in Maryland, even small teaching programs add to hospital costs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEACHING hospitals
KW - MEDICAL centers
KW - MEDICINE -- Study & teaching (Graduate)
KW - COST
KW - MARYLAND
KW - UNITED States
N1 - Accession Number: 2861098; Duffy, Sarah Q. Ruseski, Jane E. Cavanaugh, Sean Duffy, S Q 1 Ruseski, J E Cavanaugh, S; Affiliation: 1: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA; Source Info: Mar2000, Vol. 57 Issue 1, p3; Subject Term: TEACHING hospitals; Subject Term: MEDICAL centers; Subject Term: MEDICINE -- Study & teaching (Graduate); Subject Term: COST; Subject Term: MARYLAND; Subject Term: UNITED States; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 21p; Document Type: journal article; Full Text Word Count: 9595
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ER -
TY - JOUR
AU - Fisher, William
AU - Packer, Ira
AU - Grisso, Thomas
AU - McDermeit, Melissa
AU - Brown, Julie-Marie
T1 - From Case Management to Court Clinic: Examining Forensic System Involvement of Persons with Severe Mental Illness.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2000/03//
VL - 2
IS - 1
M3 - Article
SP - 41
EP - 49
SN - 15223434
AB - The study examined the flow of a state mental health agency's case-managed clients into its forensic mental health court clinic systems for evaluation of competency to stand trial (CST) for a criminal offense. An analysis of merged encounter data from the case management and court clinic systems revealed that roughly 2% of the case-managed population were referred to court clinics for evaluation of CST during a 1-year period, but that these 2% represented roughly one eighth of that year's court clinic evaluees. The likelihood of this involvement was higher for males, African-Americans, and Latinos, and for persons with a history of substance abuse, and also was associated with higher levels of previous hospitalization. In addition, CST evaluees were more likely to be non-White, male, and uninsured than were case-managed evaluees. These data indicate that demographic characteristics, substance abuse, and lack of insurance are potential risk factors for forensic and, by inference, criminal justice system involvement among persons with mental illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - PATHOLOGICAL psychology
KW - MENTAL illness
KW - MENTAL health services
KW - HOSPITALS -- Case management services
KW - competency to stand trial
KW - forensic mental health services
KW - mental health/criminal justice interface
N1 - Accession Number: 50189230; Fisher, William 1; Email Address: Bill.Fisher@umassmed.edu Packer, Ira 1 Grisso, Thomas 1 McDermeit, Melissa 2 Brown, Julie-Marie 1; Affiliation: 1: Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester 2: Lighthouse Institute of Chestnut Health Services, Bloomington; Source Info: Mar2000, Vol. 2 Issue 1, p41; Subject Term: MENTAL health; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL illness; Subject Term: MENTAL health services; Subject Term: HOSPITALS -- Case management services; Author-Supplied Keyword: competency to stand trial; Author-Supplied Keyword: forensic mental health services; Author-Supplied Keyword: mental health/criminal justice interface; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 9p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1023/A:1010143924699
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Monheit, Alan C.
AU - Vistnes, Jessica Primoff
T1 - Race/Ethnicity and Health Insurance Status: 1987 and 1996.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 11
EP - 35
SN - 10775587
AB - Health insurance confers important private and social benefits. Disparities in coverage among the population remain an important public policy issue. The authors focus on the health insurance status of white, black, and Hispanic Americans in both 1987 and 1996 and identify gaps in minority health care coverage relative to white Americans. They also investigate the access of workers in these groups to employment-based health insurance. Identified are factors underlying changes in the insurance status of workers during the past decade in terms of changes in population characteristics and structural shifts underlying the demand for and supply of health insurance. The authors find that while coverage has declined for workers in most racial/ethnic groups, the experience of Hispanic males appears to be unique in that changes in their characteristics as well as structural shifts account for their decline in employment-related coverage. Structural shifts dominated the changes in coverage rates for other groups. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926031; Monheit, Alan C. 1 Vistnes, Jessica Primoff 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Supplement 1, Vol. 57 Issue S1, p11; Number of Pages: 25p; Document Type: Article; Full Text Word Count: 9713
L3 - 10.1177/107755870005700102
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weinick, Robin M.
AU - Zuvekas, Samuel H.
AU - Cohen, Joel W.
T1 - Racial and Ethnic Differences in Access to and Use of Health Care Services, 1977 to 1996.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 36
EP - 54
SN - 10775587
AB - This article focuses on racial and ethnic disparities in health care, describing both absolute differences and relative changes in access to care and the use of health services among whites, blacks, and Hispanics over the past two decades. Using data from a series of three nationally representative medical expenditure surveys, the authors present descriptive statistics on disparities in access and use between minorities and whites over time. They also use multivariate analyses to isolate the extent to which health insurance and income explain those disparities. The authors find that disparities increased between 1977 and 1996, particularly for Hispanic Americans. Results also show that approximately one half to three quarters of the disparities observed in 1996 would remain even if racial and ethnic disparities in income and health insurance coverage were eliminated. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926032; Weinick, Robin M. 1 Zuvekas, Samuel H. 1 Cohen, Joel W. 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Supplement 1, Vol. 57 Issue S1, p36; Number of Pages: 19p; Document Type: Article; Full Text Word Count: 7176
L3 - 10.1177/107755870005700103
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DB - aph
ER -
TY - JOUR
AU - Brach, Cindy
AU - Fraserirector, Irene
T1 - Can Cultural Competency Reduce Racial and Ethnic Health Disparities? A Review and Conceptual Model.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/03/02/Supplement 1
VL - 57
IS - S1
M3 - Article
SP - 181
EP - 217
SN - 10775587
AB - This article develops a conceptual model of cultural competency’s potential to reduce racial and ethnic health disparities, using the cultural competency and disparities literature to lay the foundation for the model and inform assessments of its validity. The authors identify nine major cultural competency techniques: interpreter services, recruitment and retention policies, training, coordinating with traditional healers, use of community health workers, culturally competent health promotion, including family/community members, immersion into another culture, and administrative and organizational accommodations. The conceptual model shows how these techniques could theoretically improve the ability of health systems and their clinicians to deliver appropriate services to diverse populations, thereby improving outcomes and reducing disparities. The authors conclude that while there is substantial research evidence to suggest that cultural competency should in fact work, health systems have little evidence about which cultural competency techniques are effective and less evidence on when and how to implement them properly. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54926038; Brach, Cindy 1 Fraserirector, Irene 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Supplement 1, Vol. 57 Issue S1, p181; Number of Pages: 37p; Document Type: Article; Full Text Word Count: 15610
L3 - 10.1177/107755870005700109
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lundgren, Anna Karin
AU - Lundgren, Dan
AU - Hämmerle, Christoph H. F.
AU - Nyman, Sture
AU - Sennerby, Lars
T1 - Influence of decortication of the donor bone on guided bone augmentation.
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
Y1 - 2000/04//
VL - 11
IS - 2
M3 - Article
SP - 99
EP - 106
SN - 09057161
AB - The aim of the present study was to evaluate if early access to the endosteal bone compartment by removal of the outer cortical bone plate will enhance bone augmentation in a secluded space. Two titanium cylinders were placed on the skull of each of 8 rabbits. Each cylinder was placed into a circular slit, secured to the skull bone via two mini-screws and supplied with a titanium lid. On the test side, the outer plate of the cortical bone, demarcated by the slit, was removed.The subsequent bleeding resulted in blood fill of the cylinders to various degrees. On the control side, the cortical bone plate was left intact and no bleeding was observed at the time of the placement of the titanium lids. After 3 months, the animals were sacrificed to obtain histology and histomorphometry. No differences in the total amount of augmented bone tissue, in relation to the total experimental area (75.5%±10.9% at the test sites and 71.2%±13.5% at the control sites) or of the augmented mineralized bone tissue in relation to the total amount of augmented bone tissue, was revealed (17.8%±3.0% and 16.0%±4.9% respectively). There was no difference in the morphological appearance of the augmented bone between test and control sites and there were no obvious similarities in the appearance between the newly formed bone tissue and the donor bone. The augmented bone consisted of slender bone trabeculae, distributed in abundant marrow spaces. A conspicuous finding was that the bone trabeculae tended to climb along the inner walls of the titanium cylinder. It is concluded that decortication of the calvarial bone in the rabbit does not result in more bone formation beyond the skeletal envelope after a healing period of 3 months compared to no removal of the cortical bone plate inside a secluded experimental area. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Oral Implants Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUIDED bone regeneration
KW - SKULL -- Surgery
KW - Decortication
KW - guided bone augmentation
KW - guided bone regeneration
KW - rabbit model
N1 - Accession Number: 5789141; Lundgren, Anna Karin 1 Lundgren, Dan 1,2 Hämmerle, Christoph H. F. 3 Nyman, Sture 1,4 Sennerby, Lars 1,5; Affiliation: 1: Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Göteborg University, Sweden ; 2: Institute for Postgraduate Dental Education, Jönköping, Sweden ; 3: School of Dental Medicine, University of Berne, Switzerland ; 4: Faculty of Odontology, Göteborg University, Sweden ; 5: Brånemark Clinic, Public Health Service and Göteborg University, Sweden; Source Info: Apr2000, Vol. 11 Issue 2, p99; Subject Term: GUIDED bone regeneration; Subject Term: SKULL -- Surgery; Author-Supplied Keyword: Decortication; Author-Supplied Keyword: guided bone augmentation; Author-Supplied Keyword: guided bone regeneration; Author-Supplied Keyword: rabbit model; Number of Pages: 8p; Document Type: Article
L3 - 10.1034/j.1600-0501.2000.011002099.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Black, L.E.
AU - Green, J.D.
AU - Rener, J.
AU - Dayan, A.
AU - Cavagnaro, J.A.
AU - Spindler, P.
AU - Bussiere, J.L.
AU - Bouchard, P.
AU - Inoue, T.
AU - Thomas, P.T.
AU - Essayan, D.M.
AU - Gillett, N.A.
AU - Hart, T.K.
AU - Hastings, K.
AU - House, R.V.
AU - Latta, D.
AU - Liminga, U.
AU - Treacy, G.
AU - Wierda, D.
T1 - Safety evaluation of immunomodulatory biopharmaceuticals: can we improve the predictive value of preclinical studies?
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 205
EP - 207
PB - Sage Publications, Ltd.
SN - 09603271
AB - Presents information about a conference on safety evaluation. Introduction of immunomodulators for diseases of the immune system; Discussion on ways to improve the predictive value of preclinical studies; Topics addressed by papers presented at the conference.
KW - ACCIDENT prevention
KW - IMMUNOLOGICAL adjuvants
KW - IMMUNOLOGIC diseases
KW - CONGRESSES
N1 - Accession Number: 4664532; Black, L.E. 1 Green, J.D. 2 Rener, J. 3 Dayan, A. 3 Cavagnaro, J.A. 4 Spindler, P. 5 Bussiere, J.L. 6 Bouchard, P. 7 Inoue, T. 8 Thomas, P.T. 3 Essayan, D.M. 1 Gillett, N.A. 9 Hart, T.K. 10 Hastings, K. 11 House, R.V. 3 Latta, D. 12 Liminga, U. 13 Treacy, G. 14 Wierda, D. 15; Affiliation: 1: Center for Biologics Evaluation and Research 2: Biogen, Inc. 3: Covance Laboratories 4: Access BIO 5: Novo Nordisk A/S Agency 6: Immunex, Inc. 7: Genetics Institute 8: National Institute of Health Sciences, Japan 9: Sierra Biomedical, Inc. 10: SmithKline Beecham 11: Center for Drug Education and Research 12: Wyeth Ayerst Research 13: Medical Products Agency, Sweden 14: CentoCor, Inc. 15: Lilly Research Laboratories; Source Info: Apr2000, Vol. 19 Issue 4, p205; Subject Term: ACCIDENT prevention; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: IMMUNOLOGIC diseases; Subject Term: CONGRESSES; Number of Pages: 3p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Essayan, D.M.
T1 - Clinical trial design for immunomodulatory biologics.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 255
EP - 256
PB - Sage Publications, Ltd.
SN - 09603271
AB - Presents a study on biologic therapeutics. Clinical development of studies on biologic therapeutics; Clinical trial design of immunomodulatory biologics; Safety concerns of immunomodulatory biologics.
KW - BIOLOGICALS
KW - THERAPEUTICS
KW - Biologics
KW - clinical trial
KW - Immunomodulatory
KW - pharmacodynamics
KW - pharmacokinetics
KW - preclinical
N1 - Accession Number: 4664533; Essayan, D.M. 1; Affiliation: 1: U.S. Food and Drug Administration, Division of Clinical Trial Design and Analysis, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, HFM-579, 1401 Rockville Pike, Rockville, Maryland 20852-1448, USA; Source Info: Apr2000, Vol. 19 Issue 4, p255; Subject Term: BIOLOGICALS; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Biologics; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: Immunomodulatory; Author-Supplied Keyword: pharmacodynamics; Author-Supplied Keyword: pharmacokinetics; Author-Supplied Keyword: preclinical; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hastings, K.L.
T1 - Assessment of immunosuppressant drug carcinogenicity: standard and alternative animal models.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/04//
VL - 19
IS - 4
M3 - Article
SP - 261
EP - 265
PB - Sage Publications, Ltd.
SN - 09603271
AB - Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this would mean that rodent carcinogenicity bioassays would be performed under most circumstances. Immunosuppressant drugs have presented unique challenges with respect to the issue of carcinogenicity bioassays. The pharmacological activity of therapeutic immunosuppressants is thought to make them highly likely to act as promoters/cocarcinogens, even in the absence of genotoxic activity. Thus, it is assumed that this class of drug would represent a carcinogenic hazard in the absence of confirmatory standard rodent bioassay data. In addition, rodents typically have been sensitive to the pharmacological/toxicological effects of immunosuppressants. It has proven to be difficult, therefore, to conduct life-time bioassays at doses reasonably equivalent to those that would be used clinically. For this and other reasons, alternative models might be more appropriate for risk assessment with this class of drugs. Human & Experimental Toxicology (2000) 19, 261–265. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOSUPPRESSIVE agents
KW - CARCINOGENICITY testing
KW - BIOLOGICAL assay
KW - RODENTS
KW - HOMOGRAFTS
KW - Alternative models
KW - carcinogenicity
KW - Immunosuppressants
N1 - Accession Number: 4664534; Hastings, K.L. 1; Affiliation: 1: US Food and Drug Administration, Division of Special Pathogen and Immunologic Drug Products, Center for Drug Evaluation and Research, Rockville, Maryland 20857, USA; Source Info: Apr2000, Vol. 19 Issue 4, p261; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: CARCINOGENICITY testing; Subject Term: BIOLOGICAL assay; Subject Term: RODENTS; Subject Term: HOMOGRAFTS; Author-Supplied Keyword: Alternative models; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: Immunosuppressants; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hedeker, D.
AU - Siddiqui, O.
AU - Hu, F.B.
T1 - Random-effects regression analysis of correlated grouped-time survival data.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2000/04//
VL - 9
IS - 2
M3 - journal article
SP - 161
EP - 179
PB - Sage Publications, Ltd.
SN - 09622802
AB - Random-effects regression modelling is proposed for analysis of correlated grouped-time survival data. Two analysis approaches are considered. The first treats survival time as an ordinal outcome, which is either right-censored or not. The second approach treats survival time as a set of dichotomous indicators of whether the event occurred for time periods up to the period of the event or censor. For either approach both proportional hazards and proportional odds versions of the random-effects model are developed, while partial proportional hazards and odds generalizations are described for the latter approach. For estimation, a full-information maximum marginal likelihood solution is implemented using numerical quadrature to integrate over the distribution of multiple random effects. The quadrature solution allows some flexibility in the choice of distributions for the random effects; both normal and rectangular distributions are considered in this article. An analysis of a dataset where students are clustered within schools is used to illustrate features of random-effects analysis of clustered grouped-time survival data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - GROUP-randomized trials
KW - MODELS & modelmaking
KW - SMOKING -- Prevention
KW - BIOMETRY
KW - COMPARATIVE studies
KW - RESEARCH -- Methodology
KW - MEDICAL cooperation
KW - PROBABILITY theory
KW - RESEARCH
KW - SAMPLING (Statistics)
KW - STATISTICS
KW - SURVIVAL analysis (Biometry)
KW - DATA analysis
KW - EVALUATION -- Research
KW - PROPORTIONAL hazards models
KW - STATISTICAL models
KW - ODDS ratio
N1 - Accession Number: 4164567; Hedeker, D. 1 Siddiqui, O. 2 Hu, F.B. 3; Affiliation: 1: Division of Epidemiology and Biostatistics, Health Policy Research Center, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA 2: Food and Drug Administration, United States Government, USA 3: Department of Nutrition, Harvard School of Public Health, USA; Source Info: Apr2000, Vol. 9 Issue 2, p161; Subject Term: REGRESSION analysis; Subject Term: GROUP-randomized trials; Subject Term: MODELS & modelmaking; Subject Term: SMOKING -- Prevention; Subject Term: BIOMETRY; Subject Term: COMPARATIVE studies; Subject Term: RESEARCH -- Methodology; Subject Term: MEDICAL cooperation; Subject Term: PROBABILITY theory; Subject Term: RESEARCH; Subject Term: SAMPLING (Statistics); Subject Term: STATISTICS; Subject Term: SURVIVAL analysis (Biometry); Subject Term: DATA analysis; Subject Term: EVALUATION -- Research; Subject Term: PROPORTIONAL hazards models; Subject Term: STATISTICAL models; Subject Term: ODDS ratio; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 19p; Illustrations: 2 Charts, 1 Graph; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Youngmee K.
AU - Sempos, Christopher T.
AU - Barton, Curtis N.
AU - Vanderveen, John E.
AU - Yetley, Elizabeth A.
T1 - Effectiveness of Food Fortification in the United States: The Case of Pellagra.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/05//
VL - 90
IS - 5
M3 - Article
SP - 727
EP - 738
PB - American Public Health Association
SN - 00900036
AB - Objectives. We evaluated the possible role of niacin fortification of the US food supply and other concurrent influences in eliminating the nutritional deficiency disease pellagra. Methods. We traced chronological changes in pellagra mortality and morbidity and compared them with the development of federal regulations, state laws, and other national activities pertaining to the fortification of cereal-grain products with niacin and other B vitamins. We also compared these changes with other concurrent changes that would have affected pellagra mortality or morbidity. Results. The results show the difficulty Of evaluating the effectiveness of a single public health initiative such as food fortification without controlled experimental trials. Nonetheless, the results provide support for the belief that food fortification played a significant role in the elimination of pellagra in the United States. Conclusions. Food fortification that is designed to restore amounts of nutrients lost through grain milling was an effective tool in preventing pellagra, a classical nutritional deficiency disease, during the 1930s and 1940s, when food availability and variety were considerably less than are currently found in the United States. (Am J Public Health, 2000;90:727-738) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NIACIN
KW - FOOD supply
KW - PELLAGRA
KW - DEFICIENCY diseases
KW - MORTALITY
KW - UNITED States
N1 - Accession Number: 3060732; Park, Youngmee K. 1; Email Address: ypark@cfsan.fda.gov Sempos, Christopher T. 2 Barton, Curtis N. 1 Vanderveen, John E. 1 Yetley, Elizabeth A. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 2: Department of Social and Preventive Medicine, SUNY, Buffalo, NY; Source Info: May2000, Vol. 90 Issue 5, p727; Subject Term: NIACIN; Subject Term: FOOD supply; Subject Term: PELLAGRA; Subject Term: DEFICIENCY diseases; Subject Term: MORTALITY; Subject Term: UNITED States; Number of Pages: 12p; Illustrations: 6 Graphs; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Proctor, Enola K.
AU - Morrow-Howell, Nancy
AU - Hong Li
AU - Dore, Peter
T1 - ADEQUACY OF HOME CARE AND HOSPITAL READMISSION FOR ELDERLY CONGESTIVE HEART FAILURE PATIENTS.
JO - Health & Social Work
JF - Health & Social Work
Y1 - 2000/05//
VL - 25
IS - 2
M3 - Article
SP - 87
PB - Oxford University Press / USA
SN - 03607283
AB - Readmission to acute care facilities is a frequent and costly problem among older adults with congestive heart failure (CHF). The study reported in this article tested the hypothesis that adequate home care, operationalized as patient-perceived adequacy of formal and informal assistance, is associated with lower readmission to acute care facilities. The study followed 253 elderly (age 65 and older) Medicare patients discharged to their homes after hospitalization for CHF, through structured telephone interviews at two, six, 10, and 14 weeks postdischarge. Study findings point to the importance of home care in reducing the high risk of readmission among elderly patients. The findings raise implications for practice, policy and research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health & Social Work is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER people -- Home care
KW - CONGESTIVE heart failure
KW - OLDER people
KW - MEDICAL care for the aged
KW - CARING
KW - HEALTH facilities -- Discharge planning
KW - congestive heart failure
KW - discharge planning
KW - elderly people
KW - home care
KW - readmission
N1 - Accession Number: 3151393; Proctor, Enola K. 1; Email Address: ekp@gwbmail.wustl.edu Morrow-Howell, Nancy 2 Hong Li 3 Dore, Peter 4; Affiliation: 1: Frank J. Bruno Professor of Social Work, George Warren Brown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130. 2: Associate Professor, George Warren Brown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130. 3: Assistant Professor, University of Illinois, Urbana-Champaign. 4: Database administrator, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis.; Source Info: May2000, Vol. 25 Issue 2, p87; Subject Term: OLDER people -- Home care; Subject Term: CONGESTIVE heart failure; Subject Term: OLDER people; Subject Term: MEDICAL care for the aged; Subject Term: CARING; Subject Term: HEALTH facilities -- Discharge planning; Author-Supplied Keyword: congestive heart failure; Author-Supplied Keyword: discharge planning; Author-Supplied Keyword: elderly people; Author-Supplied Keyword: home care; Author-Supplied Keyword: readmission; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6249
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Galvin, Deborah M.
AU - Galvin, D M
T1 - Workplace managed care: collaboration for substance abuse prevention.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 2000/05//
VL - 27
IS - 2
M3 - journal article
SP - 125
EP - 130
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - This article describes the history, purpose, and overall methodology of the Workplace Managed Care (WMC) study sponsored by the Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention (CSAP). This study was initiated to discern best practices for workplaces and managed care organizations integrating their substance abuse prevention and early intervention programs, strategies, and activities for employees and their families. CSAP funded nine WMC grants to study their retrospective and prospective data. Results of the WMC study suggested the addition of substance abuse prevention material to existing workplace health promotion offerings that resulted in improved substance abuse attitudes without jeopardizing existing health promotion programs. Stress management programming was successful at improving substance abuse attitudes indirectly. This study provides a platform for multidisciplinary research in workplace and managed care settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Behavioral Health Services & Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - SUBSTANCE abuse -- Prevention
KW - EMPLOYEE health promotion
KW - UNITED States
N1 - Accession Number: 3064017; Galvin, Deborah M. Galvin, D M 1; Affiliation: 1: Division of Workplace Programs, Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, Rockville, MD 20878, USA; Source Info: May2000, Vol. 27 Issue 2, p125; Subject Term: SUBSTANCE abuse; Subject Term: SUBSTANCE abuse -- Prevention; Subject Term: EMPLOYEE health promotion; Subject Term: UNITED States; Number of Pages: 6p; Document Type: journal article; Full Text Word Count: 3514
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaftarian, Shakeh Jackie
AU - Wandersman, Abraham
T1 - Bridging the gap between research and practice in community-based substance abuse prevention.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 2000/05//
VL - 28
IS - 3
M3 - Article
SP - 237
EP - 240
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - The article focuses on efforts of the government to bridge the gap between research and practice in community-based substance abuse prevention in the U.S. Family and community factors contribute to substance abuse. Family and community solutions are necessary to prevent substance abuse. To foster and accelerate the adoption of new scientific knowledge into prevention practice, people must work to overcome the gap between research and practice highlighted by both prevention researchers and practitioners. Bridging this gap requires innovative thinking, a problem-solving orientation, and attention to the most effective modes of dissemination and diffusion.
KW - SUBSTANCE abuse -- Prevention
KW - HEALTH promotion
KW - DRUG abuse
KW - FAMILIES
KW - COMMUNITY psychology
KW - POLICY sciences
KW - UNITED States
N1 - Accession Number: 11771780; Kaftarian, Shakeh Jackie 1 Wandersman, Abraham 2; Affiliation: 1: Center for Substance Abuse Prevention. 2: University of South Carolina.; Source Info: May2000, Vol. 28 Issue 3, p237; Subject Term: SUBSTANCE abuse -- Prevention; Subject Term: HEALTH promotion; Subject Term: DRUG abuse; Subject Term: FAMILIES; Subject Term: COMMUNITY psychology; Subject Term: POLICY sciences; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - Petersen, Martin R.
AU - Deddens, James A.
T1 - Effects of omitting a covariate in poisson models when the data are balanced.
JO - Canadian Journal of Statistics
JF - Canadian Journal of Statistics
Y1 - 2000/06//
VL - 28
IS - 2
M3 - Article
SP - 439
EP - 445
SN - 03195724
AB - Les auteurs montrent que dans un modèle de Poisson multiplicatif èquilibré, les estimations des effets et de leur erreur standard ne sont pas affectées par le retrait d'une variable exogéne. Comme ils le soulignent, ceci n'est vrai ni dans le modèle Iinéaire analogue, ni dans le modèle logistique. Dans le premier cas, seules les estimations des effets restent généralement les měs le deuxième, toutes les estimations peuvent changer. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Statistics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POISSON processes
KW - LINEAR models (Statistics)
KW - MAXIMUM likelihood statistics
KW - LOGISTIC model (Demography)
KW - POPULATION -- Mathematical models
N1 - Accession Number: 61888087; Petersen, Martin R. 1 Deddens, James A. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Mail Stop R13 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA; Source Info: Jun2000, Vol. 28 Issue 2, p439; Subject Term: POISSON processes; Subject Term: LINEAR models (Statistics); Subject Term: MAXIMUM likelihood statistics; Subject Term: LOGISTIC model (Demography); Subject Term: POPULATION -- Mathematical models; Number of Pages: 7p; Document Type: Article
L3 - 10.2307/3315990
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turturro, A.
AU - Hass, B.S.
AU - Hart, R.W.
T1 - Does caloric restriction induce hormesis?
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/06//
VL - 19
IS - 6
M3 - Article
SP - 320
EP - 329
PB - Sage Publications, Ltd.
SN - 09603271
AB - The question of whether caloric restriction (CR) is hormetic is addressed in terms of two common definitions of the term. In terms of the older definition, i.e., a growth-stimulatory effect when lower doses of a compound which resulted in growth inhibition at higher doses, CR is better characterized as a co-hormetic (i.e., a paradigm which at relatively “low doses,” in combination with some stimulus, will evince increased growth (proliferation) and at higher “doses” will inhibit this increased proliferation) rather than a hormetic agent. Mechanisms such as cellular selection of cellular subpopulations, increases in receptor efficiency, and preservation of cellular proliferative potential can interact with agents and produce increased growth as long as the CR is not too severe. In terms of a broader definition, i.e., nonmonotonic dose–response behavior of a compound for any adverse response, CR appears to be hormetic, both as a result of body weight (BW) loss and other potential mechanisms. The impact of changes in BW, or frank CR, can be considered a component of every test for hormesis, and is thus capable for interaction with any other agent. The changes that BW loss (or CR) induce are so profound that any aspect of an agent's action — metabolism, pharmacokinetics, pharmacodynamics — can modulate the response of an organism to an agent. Similarly, other effects of a chemical that induce BW loss, e.g., physical activity or temperature dysregulation, can also induce dose–response curves that appear hormetic. The interaction of the hormetic agents of BW loss and CR can influence agent tests. Controlling these factors may make it possible to dissect the key components of a hormetic response. In addition, the effects of CR or BW loss appear to extrapolate well across species [Colman R, Kemnitz JW. Aging experiments using nonhuman primates. In: Yu BP (Ed), Methods in Aging Research. CRC Press, Boca Raton, FL, 1999, pp. 249–267]. Thus there is some reason to believe that these hormetic factors may be important for humans, and may already be a factor for tests of potentially adverse agents already conducted in humans. Human & Experimental Toxicology (2000) 19, 320–329. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Experimental Toxicology is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - HORMESIS
KW - PHARMACOKINETICS
KW - body weight
KW - caloric restriction
KW - Diet restriction
KW - hormesis
N1 - Accession Number: 4664197; Turturro, A. 1 Hass, B.S. 2 Hart, R.W. 3; Affiliation: 1: Food and Drug Administration, Division of Biometry and Risk Assessment, National Center for Toxicological Research (NCTR), Jefferson, Arkansas 72079, USA 2: NCTR, Division of Genetic and Reproductive Toxicology 3: NCTR, Office of the Director; Source Info: Jun2000, Vol. 19 Issue 6, p320; Subject Term: LOW-calorie diet; Subject Term: HORMESIS; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: body weight; Author-Supplied Keyword: caloric restriction; Author-Supplied Keyword: Diet restriction; Author-Supplied Keyword: hormesis; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turturro, A.
AU - Hass, B.S.
AU - Hart, R.W.
T1 - Response to the commentaries on “Does caloric restriction induce hormesis?”.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2000/06//
VL - 19
IS - 6
M3 - Article
SP - 355
EP - 359
PB - Sage Publications, Ltd.
SN - 09603271
AB - Responds to a comment on the role of caloric restriction in hormesis. Concerns raised about the concept of malnutrition; Inconsistencies in the definitions of the components of hormesis; Limitations of the Gompertzian analysis.
KW - LOW-calorie diet
KW - HORMESIS
N1 - Accession Number: 4664186; Turturro, A. 1 Hass, B.S. 2 Hart, R.W. 3; Affiliation: 1: Food and Drug Administration, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079 (NCTR) USA 2: NCTR, Division of Genetic and Reproductive Toxicology 3: NCTR, Office of the Director; Source Info: Jun2000, Vol. 19 Issue 6, p355; Subject Term: LOW-calorie diet; Subject Term: HORMESIS; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Yi-Hsuan
AU - Fang, Kwang-Ming
AU - Yang, Chuen-Mao
AU - Hwang, Hwa-Min
AU - Chiu, Chi-Tso
AU - Tsai, Wuhong
T1 - Kainic Acid-Induced Neurotrophic Activities in Developing Cortical Neurons.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2000/06//
VL - 74
IS - 6
M3 - Article
SP - 2401
EP - 2411
PB - Wiley-Blackwell
SN - 00223042
AB - Using primary cultured cortical neurons from embryonic rat brains, we elucidated an α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainic acid (KA) receptor-mediated neuroprotective mechanism through actions of nerve growth factor (NGF) in developing neurons. Neurotoxicity of KA in early days in vitro neurons was quite low compared with the mature neurons. However, pretreatment with anti-NGF antibody or TrkA inhibitor AG-879 profoundly raised KA toxicity. Furthermore, KA stimulation resulted in an increase of TrkA expression and phosphorylation, which was blocked not only by the AMPA/KA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione and AG-879, but also by the phospholipase C inhibitor U73122 and the intracellular calcium chelator BAPTA. A study of polyphosphoinositide turnover showed that KA-stimulated phospholipase C (PLC) activity was directly triggered by the AMPA/KA receptor activity, but not by the activity of TrkA or other excitatory amino acid receptor subtypes. Sources of KA-increased intracellular calcium levels were contributed by both extracellular calcium influx and intracellular calcium release and were partially sensitive to guanosine 5′-O-(2-thiodiphosphate). These results indicate that in developing cortical neurons, activation of AMPA/KA receptors by KA may induce expression, followed by activation of TrkA via PLC signaling and intracellular calcium elevation and hence increase reception of NGF on KA-challenged neurons. A G protein-coupled AMPA/KA receptor may be involved in these metabotropic events for neuronal protection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROPIONATES
KW - KAINIC acid
KW - NEURONS
KW - α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainic acid receptors
KW - Calcium
KW - Kainic acid
KW - Nerve growth factor
KW - Neuroprotection
KW - Phospholipase C
N1 - Accession Number: 5604339; Lee, Yi-Hsuan 1 Fang, Kwang-Ming 2 Yang, Chuen-Mao 3 Hwang, Hwa-Min 4 Chiu, Chi-Tso 3 Tsai, Wuhong 5; Affiliation: 1: Department of Physiology, Taipei Medical College, Taipei Taiwan, Republic of China 2: Graduate Institute of Medicine, Taipei Medical College, Taipei, Taiwan, Republic of China 3: Department of Pharmacology, Chang Gung University, Taoyuan, Taiwan, Republic of China 4: Department of Anatomy, Chang Gung University, Taoyuan, Taiwan, Republic of China 5: Antiviral Research Lab, CDER, Food and Drug Administration, Rockville, Maryland, U.S.A.; Source Info: Jun2000, Vol. 74 Issue 6, p2401; Subject Term: PROPIONATES; Subject Term: KAINIC acid; Subject Term: NEURONS; Author-Supplied Keyword: α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainic acid receptors; Author-Supplied Keyword: Calcium; Author-Supplied Keyword: Kainic acid; Author-Supplied Keyword: Nerve growth factor; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Phospholipase C; Number of Pages: 11p; Document Type: Article
L3 - 10.1046/j.1471-4159.2000.0742401.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie R.
AU - Thomas, Kathleen
T1 - Medicaid and African American Outpatient Mental Health Treatment.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2000/06//
VL - 2
IS - 2
M3 - Article
SP - 115
EP - 120
SN - 15223434
AB - The present study tested the hypothesis that Medicaid-financed African Americans would be more likely to receive outpatient mental health treatment than African Americans whose treatment was financed by private insurance. The hypothesis was confirmed: when compared with privately insured persons eligible for care under either fee-for-service or managed care, the Black–White gap in outpatient service use was significantly smaller under Medicaid. There was no racial difference in outpatient treatment rates among the uninsured. The often-noted difference between Blacks and Whites in the likelihood of receiving outpatient mental health treatment is confined largely to the privately insured. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAID
KW - OUTPATIENT medical care
KW - AFRICAN Americans -- Mental health
KW - HEALTH insurance
KW - RACIAL differences
KW - UNITED States
KW - African Americans
KW - Medicaid
KW - mental health financing
KW - outpatient treatment
N1 - Accession Number: 50189239; Snowden, Lonnie R. 1,2; Email Address: snowden@uclink4.berkeley.edu Thomas, Kathleen 3; Affiliation: 1: Center for Mental Health Services Research, School of Social Welfare, University of California at Berkeley, Berkeley, California. 2: Haviland Hall, University of California at Berkeley, Berkeley, California 94720-7400. 3: Levy Economic Institute, Chapel Hill, North Carolina.; Source Info: Jun2000, Vol. 2 Issue 2, p115; Subject Term: MEDICAID; Subject Term: OUTPATIENT medical care; Subject Term: AFRICAN Americans -- Mental health; Subject Term: HEALTH insurance; Subject Term: RACIAL differences; Subject Term: UNITED States; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: Medicaid; Author-Supplied Keyword: mental health financing; Author-Supplied Keyword: outpatient treatment; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 6p; Document Type: Article
L3 - 10.1023/A:1010161222515
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bahrke, M.S.
AU - Yesalis, C.E.
AU - Kopstein, A.N.
AU - Stephens, J.A.
T1 - Risk Factors Associated With Anabolic-Androgenic Steroid Use Among Adolescents.
JO - Sports Medicine
JF - Sports Medicine
Y1 - 2000/06//
VL - 29
IS - 6
M3 - Article
SP - 397
EP - 405
SN - 01121642
AB - To identify risk factors associated with anabolic-androgenic steroid (AAS) use among adolescents, computerised and manual literature searches were performed and the resultant local, state, national and international reports of illicit AAS use by adolescents that referenced risk factors were reviewed. Results indicate that adolescent AAS users are significantly more likely to be males and to use other illicit drugs, alcohol and tobacco. Student athletes are also more likely than non-athletes to use AAS, and football players, wrestlers, weightlifters and bodybuilders have significantly higher prevalence rates than students not engaged in these activities. Currently, only a partial profile can be created to characterise the adolescent AAS user. Further research will be needed before associations can be made with a reasonable degree of confidence regarding risk factors such as athletic participation, ethnicity, socioeconomic status and educational level. More importantly, to improve prevention and intervention strategies, a better understanding of the process involved in initiating AAS use is needed, including vulnerability factors, age of initiation and the use of other illicit drugs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sports Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANABOLIC steroids
KW - TEENAGERS
KW - Adolescents
KW - Anabolic steroids, abuse
KW - Hormonal steroids, abuse
N1 - Accession Number: 9593783; Bahrke, M.S. 1 Yesalis, C.E. 2 Kopstein, A.N. 3 Stephens, J.A. 2; Affiliation: 1: Human Kinetics, Champaign, Illinois, USA 2: Pennsylvania State University, University Park, Pennsylvania, USA 3: Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA; Source Info: Jun2000, Vol. 29 Issue 6, p397; Subject Term: ANABOLIC steroids; Subject Term: TEENAGERS; Author-Supplied Keyword: Adolescents; Author-Supplied Keyword: Anabolic steroids, abuse; Author-Supplied Keyword: Hormonal steroids, abuse; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 5277
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huba, G.J.
AU - Melchior, Lisa A.
AU - Woods, Elizabeth R.
AU - Panter, A.T.
AU - Feudo, Rudy
AU - Schneir, Arlene
AU - Trevithick, Lee
AU - Wright, Eric
AU - Martinez, Ramon
AU - Sturdevant, Marsha
AU - Remafedi, Gary
AU - Greenberg, Brian
AU - Tierney, Steven
AU - Wallace, Michael
AU - Goodman, Elizabeth
AU - Tenner, Adam
AU - Marconi, Katherine
AU - Brady, Russell E.
AU - Singer, Barney
T1 - Service Use Patterns of Youth with, and at High Risk for, HIV: A Care Typology.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2000/07//
VL - 14
IS - 7
M3 - Article
SP - 359
EP - 379
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - This paper uses confirmatory structural equation models to develop and test a theoretical model for understanding the service utilization history of 4679 youth who received services from 10 national HIV/AIDS demonstration models of youth-appropriate and youth-attractive services funded by the Special Projects of National Significance (SPNS) Program, HIV/AIDS Bureau, Health Resources and Services Administration. Although the projects differ from one another in the areas of emphasis in their service models, each is targeted to youth at high risk for HIV, or those youth who have already contracted HIV. Collectively, the projects represent a comprehensive adoelscent HIV service model. This paper examines the characteristics of the services provided to young people ranging from outreach to intensive participation in medical treatment. Major typologies of service utilization are derived empirically through exploratory factor and cluster analysis methods. Confirmatory structural equation modeling methods are used to refine the exploratory results using a derivation and replication strategy and methods of statistical estimation appropriate for non-normally distributed service utilization indicators. The model hypothesizes that youth enter the service system through a general construct of connectedness to a comprehensive service model and through service-specific methods, primarily of outreach or emergency services. Estimates are made of the degree to which a comprehensive service model drives the services as opposed to specific service entry points. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - YOUTH -- United States
KW - UNITED States
N1 - Accession Number: 3422208; Huba, G.J. 1 Melchior, Lisa A. 1 Woods, Elizabeth R. 2 Panter, A.T. 3 Feudo, Rudy 4 Schneir, Arlene 5 Trevithick, Lee 6 Wright, Eric 7 Martinez, Ramon 8 Sturdevant, Marsha 9 Remafedi, Gary 10 Greenberg, Brian 11 Tierney, Steven 12 Wallace, Michael 13 Goodman, Elizabeth 2 Tenner, Adam 6 Marconi, Katherine 14 Brady, Russell E. 14 Singer, Barney 14; Affiliation: 1: The Measurement Group, Culver City, California 2: Children's Hospital of Boston, Boston, Massachusetts 3: University of North Carolina, Chapel Hill 4: Greater Bridgeport Adolescent Pregnancy Project, Bridgeport, Connecticut 5: Children's Hospital Los Angeles, Los Angeles, California 6: YouthCare, Seattle, Washington 7: Indiana University Purdue University Indianapolis, Indiana 8: Bay Area Young Positives, San Francisco, California 9: University of Alabama, Birmingham 10: University of Minnesota Youth and AIDS Project, Minneapolis 11: Walden House, San Francisco, California 12: Health Initiatives for Youth, San Francisco, California 13: Indiana State Department of Health, Indianapolis, Indiana 14: Health Resources and Services Administration, Rockville, Maryland; Source Info: Jul2000, Vol. 14 Issue 7, p359; Subject Term: HIV-positive persons -- Medical care; Subject Term: YOUTH -- United States; Subject Term: UNITED States; Number of Pages: 21p; Illustrations: 1 Diagram, 9 Charts, 1 Graph; Document Type: Article
L3 - 10.1089/108729100413239
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marcus, Marvin
AU - Freed, James R.
AU - Coulter, Ian D.
AU - Der-Martirosian, Claudia
AU - William Cunningham
AU - Andersen, Ronald
AU - Garcia, Isabel
AU - Schneider, Donald A.
AU - Maas, William R.
AU - Bozzette, Samuel A.
AU - Shapiro, Martin F.
T1 - Perceived Unmet Need for Oral Treatment Among a National Population of HIV-Positive Medical Patients: Social and Clinical Correlates.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/07//
VL - 90
IS - 7
M3 - Article
SP - 1059
EP - 1063
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examines social. behavioral, and clinical correlates of perceived unmet need for oral health care for people with HIV infection. Methods. Baseline in-person interviews with 2864 individuals were conducted with the HIV Cost and Services Utilization Study cohort, a nationally representative probability sample of HIV-infected persons in medical care. Bivariate and logistic regression analyses were conducted, with unmet need in the last 6 months as the dependent variable and demographic, social, behavioral, and disease characteristics as independent variables. Results. We estimate that 19.3% of HIV-infected medical patients (n = 44550) had a perceived unmet need for dental care in the last 6 months. The odds of having unmet dental needs were highest for those on Medicaid in states without dental benefits (odds ratio [OR]=2.21), for others with no dental insurance (OR=2.26), for those with incomes under $5000 (OR=2.20), and for those with less than a high school education (OR=1.83). Low CD4 count was not significant. Conclusions. Perceived unmet need was related more to social and economic factors than to stage of infection. An expansion of dental benefits for those on Medicaid might reduce unmet need for dental care. (Am J Public Health. 2000;90:1059-1063) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - MEDICAL care
KW - PATIENTS
KW - MEDICARE
KW - INTERPERSONAL relations
KW - DEMOGRAPHY
N1 - Accession Number: 3270044; Marcus, Marvin 1,2; Email Address: mamarcus@ucla.edu Freed, James R. 1 Coulter, Ian D. 1,3 Der-Martirosian, Claudia 1 William Cunningham 4 Andersen, Ronald 5 Garcia, Isabel 6 Schneider, Donald A. 7 Maas, William R. 8 Bozzette, Samuel A. 3,9 Shapiro, Martin F. 3,4; Affiliation: 1: School of Dentistry, University of California at Los Angeles. 2: Chair, HCSUS Oral Health Team. 3: RAND, Santa Monica, Calif. 4: School of Medicine, University of California at Los Angeles. 5: School of Public Health, University of California at Los Angeles. 6: National Institute of Dental and Craniofacial Research, Bethesda, Md. 7: Health Care Financing Administration, Baltimore, Md. 8: Agency for Healthcare Research and Quality, Atlanta, Ga. 9: School of Medicine, University of California at San Diego.; Source Info: Jul2000, Vol. 90 Issue 7, p1059; Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: PATIENTS; Subject Term: MEDICARE; Subject Term: INTERPERSONAL relations; Subject Term: DEMOGRAPHY; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Devers, Kelly J.
AU - Frankel, Richard M.
T1 - Study Design in Qualitative Research—2: Sampling and Data Collection Strategies.
JO - Education for Health: Change in Learning & Practice (Taylor & Francis Ltd)
JF - Education for Health: Change in Learning & Practice (Taylor & Francis Ltd)
Y1 - 2000/07//
VL - 13
IS - 2
M3 - Article
SP - 263
EP - 271
PB - Taylor & Francis Ltd
SN - 13576283
AB - In two prior papers in our series on qualitative research [Frankel & Devers (2000a, 2000b) Qualitative research: a consumer's guide, Education for Health, 13, 113-123; Frankel & Devers (2000) Study design in qualitative research-1: developing research questions and assessing research needs, Education for Health, 13, 251-261], we examine two critical issues in qualitative research design: sampling, including identifying and negotiating access to research sites and subjects, and data collection and management. We describe these two key steps in the qualitative research design process, discuss challenges that often emerge when pursuing these steps, and provide guidelines for addressing them. Qualitative research most often uses "purposive," rather than random, sampling strategies. A good understanding of these sampling strategies and why they are used is central to designing a credible qualitative study. In addition, given the real-world context in which most qualitative research is carried out, identifying and negotiating access to research sites and subjects are critical parts of the process. We also provide suggestions for developing and maintaining productive and mutually satisfying research relationships with sites and subjects. Finally, data collection and management are often neglected subjects in qualitative research. We offer practical advice on how to collect and manage qualitative data, including factors to consider when deciding how structured the data collection process should be, the pros and cons of audio- and/or videotaping compared with note-taking, and tips for writing up field notes and document management. A forthcoming, final paper in the series will focus on qualitative data analysis and the publication of qualitative research results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Education for Health: Change in Learning & Practice (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITATIVE research
KW - COMPUTERS in research
N1 - Accession Number: 3635418; Devers, Kelly J. 1 Frankel, Richard M. 2; Affiliation: 1: Research Fellow, Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD, USA 2: Professor of Medicine and Community, and Preventive Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA; Source Info: Jul2000, Vol. 13 Issue 2, p263; Subject Term: QUALITATIVE research; Subject Term: COMPUTERS in research; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 3715
L3 - 10.1080/13576280050074543
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verthelyi, D.
AU - Klinman, D. M.
T1 - Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo.
JO - Immunology
JF - Immunology
Y1 - 2000/07//
VL - 100
IS - 3
M3 - Article
SP - 384
EP - 390
PB - Wiley-Blackwell
SN - 00192805
AB - Summary This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-α (TNF-α) or interferon-γ (IFN-γ) in vivo. Simultaneous assessment of serum hormone levels and cytokine-secreting cell activity throughout the menstrual cycle showed that the number of peripheral blood mononuclear cells (PBMC) able to secrete IL-4 in response to stimulation correlated significantly (P < 0·0001) with oestrogen levels and fluctuated with the menstrual cycle in pre-menopausal women. The activity of IFN-γ-secreting cells, on the other hand, varied as a function of serum DHEA-S levels in pre-menopausal women (P < 0·0001). Similarly, the number of cells secreting IFN-γ in men correlated with serum DHEA-S levels (P < 0·001). In contrast, post-menopausal women had fewer cells actively secreting cytokines and the activity of these cells did not correlate with sex hormone levels. These results suggest that sex hormones may modulate cytokine production in vivo and contribute to gender-related differences in normal and pathological immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX hormones
KW - SERUM
KW - ESTROGEN
KW - PROGESTERONE
KW - DEHYDROEPIANDROSTERONE
N1 - Accession Number: 5464891; Verthelyi, D. 1 Klinman, D. M. 1; Affiliation: 1: Retroviral Immunology Section, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Jul2000, Vol. 100 Issue 3, p384; Subject Term: SEX hormones; Subject Term: SERUM; Subject Term: ESTROGEN; Subject Term: PROGESTERONE; Subject Term: DEHYDROEPIANDROSTERONE; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stoil, Michael J.
AU - Hill, Gary A.
AU - Jansen, Mary A.
AU - Sambrano, Soledad
AU - Francis J. WinnJr., Soledad
T1 - Benefits of community-based demonstration efforts: Knowledge gained in substance abuse prevention.
JO - Journal of Community Psychology
JF - Journal of Community Psychology
Y1 - 2000/07//
VL - 28
IS - 4
M3 - Article
SP - 375
EP - 389
PB - John Wiley & Sons, Inc.
SN - 00904392
AB - Prospective studies document that preventive interventions can reduce the prevalence of substance abuse and antisocial behavior. In contrast, the justification for community-based demonstrations in substance abuse prevention and mental health promotion assumes that communities have decided to invest in prevention and now wish to learn from the experience of others on how the value of this investment can be maximized. The expectation has been that demonstration grants can be applied to improve substance abuse prevention efforts operated under State and community auspices. A review of selected knowledge gains from community-basedduration of interventions, and factors affecting implementation. Of these, the most rigorously-confirmed findings are: (1) that the transmission of generic life skills is associated with short-term reductions in substance abuse among adolescents; (2) that activities that improve self-esteem do not consistently affect adolescent substance abuse; and (3) that preventive interventions conducted among pregnant women motivated to participate produce net financial savings in hospital costs. © 2000 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Community Psychology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Prevention
KW - COMMUNITY psychology
KW - SUBSTANCE abuse
KW - MENTAL health promotion
KW - SELF-esteem
KW - HUMAN behavior
N1 - Accession Number: 11771787; Stoil, Michael J. 1 Hill, Gary A. 1 Jansen, Mary A. 2 Sambrano, Soledad 2 Francis J. WinnJr., Soledad 3; Affiliation: 1: Conwal Incorporated. 2: Center for Substance Abuse Prevention of the Substance Abuse and Mental Health Services Administration. 3: East Carolina State University.; Source Info: Jul2000, Vol. 28 Issue 4, p375; Subject Term: DRUG abuse -- Prevention; Subject Term: COMMUNITY psychology; Subject Term: SUBSTANCE abuse; Subject Term: MENTAL health promotion; Subject Term: SELF-esteem; Subject Term: HUMAN behavior; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lucas, Anne D.
AU - Tomazic-Jezic, Vesna J.
T1 - MODIFICATION OF THE LOWRY METHOD FOR ANALYSIS OF SOLUBLE LATEX PROTEINS.
JO - Toxicology Methods
JF - Toxicology Methods
Y1 - 2000/07//
VL - 10
IS - 3
M3 - Article
SP - 165
EP - 179
PB - Taylor & Francis Ltd
SN - 10517235
AB - Proteins from natura lrubber latex (NRL) can cause local and systemic reactions in people who are allergic to it. Reducing the total protein in NRL products to minimize the allergenic potential requires methods of accurately estimating the amount of protein. Previous work in this laboratory and others has indicated that, of the colorimetric assays, a modified Lowry method performs best. The American Society for Testing Materials (ASTM) has adopted the modified Lowry method for analysis of soluble NRL proteins.This method, although the best currently available, lacks sufficient reproducibility and sensitivity. In anattempt to improve the method, we address in this article the importance of various extraction conditions and additional approaches to eliminate interfering substances that may cause the false-positive values in the test. Depending on the chemical composition of the accelerants added during manufacturing processes, different means may be employed to remove or to account for the presence of these small organic molecules. The best general way to remove these chemical compounds is the partitioning of the latex extracts with ethyl acetate followed by acid precipitation. Although there is no one perfect method for all NRL proteins and products, the data presented here indicate that changes in the standard protocol of the Lowry method may result in more reproducible and reliable results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - PROTEINS
KW - ALLERGY
KW - Allergens
KW - LOWRY METHOD
KW - Natural rubber latex proteins
KW - protein quantitation
N1 - Accession Number: 3847652; Lucas, Anne D. 1 Tomazic-Jezic, Vesna J. 1; Affiliation: 1: United States Food and Drug Administration/Center for Devices and Radiological Health (US FDA/CDRH), Rockville, Maryland, USA; Source Info: Jul2000, Vol. 10 Issue 3, p165; Subject Term: LATEX; Subject Term: PROTEINS; Subject Term: ALLERGY; Author-Supplied Keyword: Allergens; Author-Supplied Keyword: LOWRY METHOD; Author-Supplied Keyword: Natural rubber latex proteins; Author-Supplied Keyword: protein quantitation; Number of Pages: 15p; Illustrations: 6 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10517230050121589
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snawder, J.E.
AU - Savage Jr, R. E.
T1 - CHARACTERIZATION OF CYTOCHROME P450-DEPENDENT AND GLUTATHIONE TRANSFERASE ACTIVITIES IN SV40-IMMORTALIZED UROEPITHELIAL CELL LINES: POSSIBLE ROLE IN TRANSFORMATION AND TUMOR FORMATION.
JO - Toxicology Methods
JF - Toxicology Methods
Y1 - 2000/07//
VL - 10
IS - 3
M3 - Article
SP - 195
EP - 201
PB - Taylor & Francis Ltd
SN - 10517235
AB - An in vitro/in vivo transformation system has been developed as a model for bladder tumorigenesis. SV40-immortalized human uroepithelial cells are exposed to putative carcinogens and then implanted into athymic nude mice to testfortumorigenesis.Studieswith4-aminobiphenyl(4-ABP)demonstratedthat one cell line, SV-HUC-PC, was sensitive to chemical-induced transformation and another line, SV-HUC-BC, was refractory.Weare currently testing this system as a model to identify occupational carcinogens and develop biomarkers of exposure and effects of exposure. As part of this study, we examined P450- dependent metabolism, glutathione transferase, and the effects of chemicals on deoxyribonucleic acid(DNA)synthesisandrepair inSV-HUC-PC andSV-HUCBC. Activities for CYP1A1/1A2, CYP3A, and CYP2B1/2B2 were estimated by determining o -dealkylation of ethoxy-, benzoxy-, and pentoxy-resorufin, respectively. Coumarin hydroxylase and p -nitrophenol hydroxylase were used to estimate CYP2A and CYP2E1, respectively. SV-HUC-PC microsomes had fivefold greaterCYP1A1/1A2activityandtwofoldhigherCYP3AactivitythanSV-HUCBC. CYP2B1/2B2 and CYP2A activities and glutathione transferase were not different between the two cell lines. DNA synthesis and repair, by BrdU incorporation, was not different between the two lines when N-methyl-N-nitroN-nitrosoguanidine (MNNG) or other reactive metabolites were tested; however, SV-HUC-PC was more sensitive to n -nitrosodimethylamine, 4-ABP, and 4,4-methylene bis (2-chloroaniline) (MOCA). The data demonstrate that, while these cells have retained form-specific P450 activities, SV-HUC-PC has greater CYP1A1/1A2 and CYP3A activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - GLUTATHIONE transferase
KW - CELL lines
KW - Glutathione transferase
N1 - Accession Number: 3847650; Snawder, J.E. 1 Savage Jr, R. E. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: Jul2000, Vol. 10 Issue 3, p195; Subject Term: CYTOCHROME P-450; Subject Term: GLUTATHIONE transferase; Subject Term: CELL lines; Author-Supplied Keyword: Glutathione transferase; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/10517230050121606
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koller, Elizabeth
AU - Mann, Marianne
AU - Malozowski, Saul
AU - Bacsanyi, Janos
AU - Gibert, Cynthia
T1 - Aseptic Necrosis in HIV Seropositive Patients: A Possible Etiologic Role for Megestrol Acetate.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2000/08//
VL - 14
IS - 8
M3 - Article
SP - 405
EP - 410
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - The association between pharmacologic doses of corticosteroids and the development of aseptic bone necrosis has been well documented. Recent reports have described the corticosteroid activity of megestrol acetate. A retrospective review of adverse events reported to the U.S. Food and Drug Administration identified three human immunodeficiency virus (HIV) seropositive patients who developed avascular necrosis of the femoral head during treatment with megestrol acetate. All were males, ages 34, 36, and 55 years, and were on therapy for 6, 1.5, and 18 months, respectively, when symptoms of aseptic necrosis occurred in the absence of antecedent trauma. Megestrol acetate doses were 640, 320, and 600–1200 mg/d, respectively. Two patients had no history of corticosteroid use whereas the third had taken an undisclosed dose and duration of corticosteroids concurrent with pentamidine administration. Notably, despite the predominant use of megestrol in women for hormone sensitive malignancies, none of the reports of aseptic necrosis occurred in this population. Megestrol acetate may be associated with the development of avascular necrosis via its glucocorticoid-like effects. Cachectic acquired immunodeficiency syndrome (AIDS) patients may have additional risk factors that predispose them to aseptic necrosis when receiving megestrol acetate. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections -- Complications
KW - BONES -- Necrosis
KW - HIV-positive persons
KW - DISEASES
KW - ADRENOCORTICAL hormones
KW - DRUGS -- Side effects
N1 - Accession Number: 3535187; Koller, Elizabeth 1 Mann, Marianne 1 Malozowski, Saul 1 Bacsanyi, Janos 1 Gibert, Cynthia 2; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 2: Department of Infectious Disease, Veteran's Administration Medical Center, Washington, D.C.; Source Info: Aug2000, Vol. 14 Issue 8, p405; Subject Term: HIV infections -- Complications; Subject Term: BONES -- Necrosis; Subject Term: HIV-positive persons; Subject Term: DISEASES; Subject Term: ADRENOCORTICAL hormones; Subject Term: DRUGS -- Side effects; Number of Pages: 6p; Illustrations: 4 Black and White Photographs, 1 Chart; Document Type: Article
L3 - 10.1089/108729100416614
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moyer, Ernest S.
AU - Bergman, M. S.
T1 - Electrostatic N-95 Respirator Filter Media Efficiency Degradation Resulting from Intermittent Sodium Chloride Aerosol Exposure.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/08//
VL - 15
IS - 8
M3 - Article
SP - 600
EP - 608
SN - 1047322X
AB - The effects of intermittently loading small masses of sodium chloride aerosol on the filtration efficiency of N-95 filtering facepiece respirators was investigated. The National Institute for Occupational Safety and Health (NIOSH) certifies that N-95 respirators must provide at least 95 percent filtration efficiency against a sodium chloride aerosol challenge as per the respirator certification (42 CFR 84) test criteria. N-95 respirators are specified for protection against solid and water-based particulates (i.e., non-oil aerosols). New N-95 respirators from three different manufacturers were loaded with 5±1 mg of sodium chloride aerosol one day a week, over a period of weeks. Aerosol loading and penetration measurements were performed using the TSI 8130 Filter Tester. Respirators were stored uncovered on an office desktop outside the laboratory. To investigate environmental and temporal effects of filters being stored without sodium chloride exposure, control respirators were stored on the desk for various lengths of time before being initiated into weekly testing. For all manufacturers' respirators, the controls showed similar initial penetrations on their day of initiation (day zero) to those of the study samples on day zero. As the controls were tested weekly, they showed similar degradation rates to those of the study samples. Results show that some of the manufacturers' models had penetrations of greater than 5 percent when intermittently exposed to sodium chloride aerosol. It is concluded that intermittent, low-level sodium chloride aerosol loading of N-95 respirators has a degrading effect on filter efficiency. This reduction in filter efficiency was not accompanied by a significant increase in breathing resistance that would signal the user that the filter needs to be replaced. Furthermore, it was noted that the effect of room storage time prior to initial exposure was much less significant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREATHING apparatus
KW - AEROSOLS (Sprays)
KW - Filter efficiency
KW - FILTER EFFICIENCY DEGRADATION
KW - Filters
KW - Respirators
KW - Sodium chloride aerosol
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 4052778; Moyer, Ernest S. 1 Bergman, M. S. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia; Source Info: Aug2000, Vol. 15 Issue 8, p600; Subject Term: BREATHING apparatus; Subject Term: AEROSOLS (Sprays); Author-Supplied Keyword: Filter efficiency; Author-Supplied Keyword: FILTER EFFICIENCY DEGRADATION; Author-Supplied Keyword: Filters; Author-Supplied Keyword: Respirators; Author-Supplied Keyword: Sodium chloride aerosol; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 9p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1080/10473220050075608
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martin Jr, Stephen B.
AU - Moyer, Ernest S.
T1 - Electrostatic Respirator Filter Media: Filter Efficiency and Most Penetrating Particle Size Effects.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/08//
VL - 15
IS - 8
M3 - Article
SP - 609
EP - 617
SN - 1047322X
AB - New electrostatic filter media has been developed for use in 42 CFR 84 negative pressure particulate respirator filters. This respirator filter media was not available for evaluation prior to the change from 30 CFR 11 to 42 CFR 84. Thus, characterization of this filter media is warranted. In this study, the new 42 CFR 84 electrostatic respirator filters were investigated with respect to filter penetration and most penetrating particle size. Three different models of N95 filters, along with one model each of the N99, R95, and P100 class filters were used in this study. First, three of each filter were loaded with a sodium chloride (NaCl) aerosol, and three of each filter were loaded with a dioctyl phthalate (DOP) aerosol to obtain normal background penetration results for each filter. Then, two new filters of each type were dipped in isopropanol for 15 seconds and allowed to dry. This isopropanol dip should reduce or eliminate any electrostatic charge on the fibers of each filter, as reported in the technical literature. These dipped filters, along with controls of each filter type, were tested on a TSI 8160 filter tester to determine the most penetrating particle size. These same filters were then tested against a NaCl aerosol to get final penetration values. Electret filters rely heavily on their electrostatic charge to provide adequate filter efficiencies, and correlations between penetration and a filter’s electrostatic characteristics are found in the technical literature. In all six of the filter models tested, filter penetration values increased considerably and the most penetrating particle size noticeably shifted toward larger particles. These results are important in better understanding how these new filter materials perform under various conditions, and they indicate the need for additional research to define environmental conditions that may affect electrostatic filter efficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FILTERS & filtration
KW - BREATHING apparatus
KW - Electrostatic
KW - Filter efficiency
KW - Filters
KW - MOST PENETRATING PARTICLE SIZE
KW - Respirators
N1 - Accession Number: 4052777; Martin Jr, Stephen B. 1 Moyer, Ernest S. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Aug2000, Vol. 15 Issue 8, p609; Subject Term: FILTERS & filtration; Subject Term: BREATHING apparatus; Author-Supplied Keyword: Electrostatic; Author-Supplied Keyword: Filter efficiency; Author-Supplied Keyword: Filters; Author-Supplied Keyword: MOST PENETRATING PARTICLE SIZE; Author-Supplied Keyword: Respirators; Number of Pages: 9p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/10473220050075617
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hrinczenko, Borys W.
AU - Alayash, Abdu I.
AU - Wink, David A.
AU - Gladwin, Mark T.
AU - Rodgers, Griffin P.
AU - Schechter, Alan N.
T1 - Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2000/08//
VL - 110
IS - 2
M3 - Article
SP - 412
EP - 419
PB - Wiley-Blackwell
SN - 00071048
AB - A mechanism has been proposed in which nitric oxide (NO) may bind to cysteine β93 and be transported by haemoglobin from the lungs to the tissues and modify vascular tone. In addition, it has been reported that treatment of sickle cell anaemia blood with 80 p.p.m. NO gas in air shifts the oxygen affinity, as measured by P50 to the left. We exposed normal and sickle cell anaemia blood to 80 p.p.m. NO in air for 1 h in vitro and found no change in P50 of either normal or sickle cell blood. In addition, we exposed normal and sickle cell blood in buffer to aqueous NO (NO gas dissolved in buffer) at varying concentrations and found that the induced left shift in P50 correlates strongly and linearly with methaemoglobin formation. We also treated normal and sickle cell blood with other nitric oxide donors, such as sodium 2-(N,N-diethylamino)-diazenolate-2-oxide (DEANO), S-nitrosocysteine (CysNO) and sodium trioxodinitrate (OXINO, or Angeli's salt). In all cases, we found a dose-dependent increase in methaemoglobin that was strongly correlated with the dose-dependent P50 reduction. Our data do not support the report that low NO concentrations can selectively increase the oxygen affinity of sickle cell blood without affecting methaemoglobin levels significantly. NO, however, may have benefit in sickle cell disease by other mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITRIC oxide
KW - ERYTHROCYTES
KW - OXYGEN -- Physiological transport
KW - SICKLE cell anemia
KW - PHYSIOLOGY
KW - haemoglobin
KW - methaemoglobin
KW - nitric oxide
KW - oxygen affinity
KW - sickle cell anaemia
N1 - Accession Number: 5604678; Hrinczenko, Borys W. 1 Alayash, Abdu I. 2 Wink, David A. 3 Gladwin, Mark T. 4 Rodgers, Griffin P. 5 Schechter, Alan N. 1; Affiliation: 1: Laboratory of Chemical Biology, NIDDK, National Institutes of Health, 2: Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 3: Division of Clinical Sciences, Radiation Biology Branch, National Cancer Institute, NIH, 4: Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, and 5: Molecular and Clinical Hematology Branch, NIDDK, National Institutes of Health, USA; Source Info: Aug2000, Vol. 110 Issue 2, p412; Subject Term: NITRIC oxide; Subject Term: ERYTHROCYTES; Subject Term: OXYGEN -- Physiological transport; Subject Term: SICKLE cell anemia; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: haemoglobin; Author-Supplied Keyword: methaemoglobin; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: oxygen affinity; Author-Supplied Keyword: sickle cell anaemia; Number of Pages: 8p; Illustrations: 4 Graphs; Document Type: Article; Full Text Word Count: 5906
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Larsen, Ulla
AU - Yan, Sharon
T1 - DOES FEMALE CIRCUMCISION AFFECT INFERTILITY AND FERTILITY? A STUDY OF THE CENTRAL AFRICAN REPUBLIC, COTE D'IVOIRE, AND TANZANIA.
JO - Demography
JF - Demography
Y1 - 2000/08//
VL - 37
IS - 3
M3 - Article
SP - 313
EP - 321
SN - 00703370
AB - The article examines the effect of female circumcision on fertility and infertility in women in Africa. The main finding of this analysis is that female circumcision is not associated with increased infertility nor with reduced fertility in the Central African Republic, Côte d'Ivoire, and Tanzania. Specifically, the relative odds of infertility and the relative odds of having a child do not differ between uncircumcised and circumcised women, regardless of their age at circumcision, when the confounding effects of socioeconomic, demographic and cultural characteristics are taken into account. Comparing the fertility of circumcised and uncircumcised women yields suggestive, but far from conclusive, information about the health effects of circumcision. One does not know what the fertility of circumcised women would have been, had they not been circumcised. Suppose that women who strongly prefer large families are those who are circumcised. They may have more children than uncircumcised women, but still may have fewer than if they had not been circumcised.
KW - FEMALE genital mutilation
KW - HUMAN fertility
KW - INFIBULATION
KW - CHILDLESSNESS
KW - CENTRAL African Republic
KW - TANZANIA
KW - COTE d'Ivoire
N1 - Accession Number: 3589669; Larsen, Ulla 1; Email Address: Ullarsen@hasph.harvard.edu Yan, Sharon 2; Affiliation: 1: Department of Population and International Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 2: Center for Drug Evaluation and Research, Food and Drug Administration.; Source Info: Aug2000, Vol. 37 Issue 3, p313; Subject Term: FEMALE genital mutilation; Subject Term: HUMAN fertility; Subject Term: INFIBULATION; Subject Term: CHILDLESSNESS; Subject Term: CENTRAL African Republic; Subject Term: TANZANIA; Subject Term: COTE d'Ivoire; Number of Pages: 9p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Lei
AU - Tinkle, Sally S.
T1 - Chemical Activation of Innate and Specific Immunity in Contact Dermatitis.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2000/08//
VL - 115
IS - 2
M3 - Article
SP - 168
EP - 176
SN - 0022202X
AB - SummaryRecent reports have suggested that chemical-induced allergic contact dermatitis may not be a traditional type IV hypersensitivity, in part due to the dual irritant and antigenic properties of sensitizing chemicals. In order to investigate the contribution of these properties to the molecular and cellular mechanism underlying allergic contact dermatitis, we evaluated oxazolone-induced changes in cell populations and cytokine production in the dermis of transgenic mice with impaired innate immunity (the FcγR subunit knockout mouse), and absent specific immunity (the athymic mouse), and the appropriate B6,129F2 and C57BL/6 control mice. Oxazolone and croton oil were applied in a single sensitizing dose, or in sensitizing and challenge doses, and the dermal response was evaluated by immunohistochemistry. In the wild type mice, with or without sensitization to oxazolone or croton oil, we observed mixed Th1/Th2 cytokine production and both CD4+ and CD8+ T lymphocytes; however, the neutrophil was the predominant cell in the dermis, even 72 h after final chemical application. Athymic mice displayed a similar neutrophil response with moderate Th1/Th2 cytokine production, and FcγR subunit knockout mice exhibited very mild dermatitis when treated with either oxazolone or croton oil. These results provide support for the hypothesis that allergic contact dermatitis is not a classic delayed type hypersensitivity, demonstrate the importance of the interaction between the irritant and antigenic properties of sensitizing chemicals in the development of allergic contact dermatitis, and suggest that the irritant effect of chemicals may be mediated through the cutaneous innate immune system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - NATURAL immunity
KW - CONTACT dermatitis
KW - cytokine
KW - innate immunity inflammation
KW - Specific immunity
N1 - Accession Number: 5508671; Zhang, Lei 1 Tinkle, Sally S. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, U.S.A.; Source Info: Aug2000, Vol. 115 Issue 2, p168; Subject Term: CYTOKINES; Subject Term: NATURAL immunity; Subject Term: CONTACT dermatitis; Author-Supplied Keyword: cytokine; Author-Supplied Keyword: innate immunity inflammation; Author-Supplied Keyword: Specific immunity; Number of Pages: 9p; Illustrations: 26 Black and White Photographs, 7 Graphs; Document Type: Article
L3 - 10.1046/j.1523-1747.2000.00999.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kruse, Michael W.
AU - Monaghan, Michael S.
AU - Troshynski, Thomas J.
T1 - Sulfonylurea Adherence and Glycemic Control in Native Americans with Type 2 Diabetes Mellitus.
JO - Journal of Pharmacoepidemiology
JF - Journal of Pharmacoepidemiology
Y1 - 2000/08//
VL - 8
IS - 1
M3 - Article
SP - 41
SN - 08966966
AB - The purpose of this study was to assess adherence to sulfonylurea monotherapy within a Native American population with type 2 diabetes mellitus. Patient medication adherence was evaluated using medical records to perform a 12-month, cross-sectional evaluation of medication refills. Adherence was defined using a continuous, multiple-interval measure of medication availability (CMA). Patients had an average of 80.5 ± 25.4 days of medication during 100 days of treatment, equivalent to a defined adherence scale of fair to poor in 58%. Because CMA may be less expensive and time-consuming than other measures of medication adherence, CMA can be used to assess medication adherence in patients at risk for developing diabetes complications, such as Native Americans. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Pharmacoepidemiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - SULFONYLUREAS
KW - NATIVE Americans
KW - CARBOHYDRATE intolerance
KW - PATIENT compliance
KW - adherence
KW - Diabetes mellitus
KW - glycemic control
N1 - Accession Number: 27707823; Kruse, Michael W. 1 Monaghan, Michael S. 2 Troshynski, Thomas J. 3; Affiliation: 1: Creighton University School of Pharmacy, 2500 California Plaza, Omaha, NE 68178. 2: Associate Professor of Pharmacy Practice, Creighton University School of Pharmacy, 2500 California Plaza, Omaha, NE 68178. 3: Chief Pharmacist, Indian Health Service, United States Public Health Service, P.O. Box 306, Fort Hall, ID 83203.; Source Info: 2000, Vol. 8 Issue 1, p41; Subject Term: DIABETES; Subject Term: SULFONYLUREAS; Subject Term: NATIVE Americans; Subject Term: CARBOHYDRATE intolerance; Subject Term: PATIENT compliance; Author-Supplied Keyword: adherence; Author-Supplied Keyword: Diabetes mellitus; Author-Supplied Keyword: glycemic control; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moorman, W. J.
AU - Cheever, K. L.
AU - Skaggs, S. R.
AU - Clark, J. C.
AU - Turner, T. W.
AU - Marlow, K. L.
AU - Schrader, S. M.
T1 - Male adolescent exposure to endocrine-disrupting pesticides: vinclozolin exposure in peripubertal rabbits.
JO - Andrologia
JF - Andrologia
Y1 - 2000/09//
VL - 32
IS - 4/5
M3 - Article
SP - 285
EP - 293
PB - Wiley-Blackwell
SN - 03034569
AB - Adolescence is a time of dramatic neuroendocrine changes that are required for sexual maturation. Hormonal mimicking or inhibiting chemicals can cause significant impairment during this critical period. Vinclozolin (Vin) has been shown to be an anti-androgen affecting male offspring in rats in utero, and its mechanism of action may be mediated by inhibition of androgenic receptor action. The majority of teenagers working on farms are male, and therefore a systemic fungicide, vinclozolin, was selected for study. The rabbit has proved to be an excellent species for modelling reproductive toxicant effects in the male and was selected as the test species. The peripubertal phase for the rabbit was determined to be between the 3rd and 4th months. A 2-month dosing period was therefore initiated at 3 months of age and carried through to the 4th month. Vin was administered by dermal application (100 mg kg-1 in 100 μl of dimethylsulphoxide) daily. Body weights were determined weekly. The rabbits were then held until fully mature (6 months of age). Semen was collected and evaluated from sexually mature males on a weekly schedule for 5 weeks to maximize sperm output. An automated solid phase extraction procedure for monitoring exposures through isolation and quantification of Vin and its metabolic products was developed. Increased plasma levels of Vin and M2 were found throughout the experimental period. The exposed rabbits had a smaller weight gain during pubertal growth (approaching significance; P=0.059). At maturity, the accessory sex glands of the exposed animals weighed less than those of the controls (P=0.016). Surprisingly, the pooled sperm count of the exposed animals was significantly higher (P=0.017) than that of the unexposed animals. The anti-androgenic effects of Vin may have blocked the negative feedback mechanism of testosterone on the hypothalamus or pituitary gland, allowing for an increase in gonadotrophin release, and consequently... [ABSTRACT FROM AUTHOR]
AB - Copyright of Andrologia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOCRINE toxicology
KW - PESTICIDES -- Physiological effect
KW - MALE reproductive organs
KW - Accessory sex gland
KW - ermal dosing
KW - etabolic products
KW - nti-androgenic
N1 - Accession Number: 5216417; Moorman, W. J. 1 Cheever, K. L. 1 Skaggs, S. R. 1 Clark, J. C. 1 Turner, T. W. 1 Marlow, K. L. 1 Schrader, S. M. 1; Affiliation: 1: Division of Biomedical and Behavioral Sciences, National Institute for Occupational Safety and Health, Cincinnati, OH, USA; Source Info: Sep2000, Vol. 32 Issue 4/5, p285; Subject Term: ENDOCRINE toxicology; Subject Term: PESTICIDES -- Physiological effect; Subject Term: MALE reproductive organs; Author-Supplied Keyword: Accessory sex gland; Author-Supplied Keyword: ermal dosing; Author-Supplied Keyword: etabolic products; Author-Supplied Keyword: nti-androgenic; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jaycox, Larry B.
AU - Olsen, Larry D.
T1 - Determination of Total Sulfur Compounds and Benzothiazole in Asphalt Fume Samples by Gas Chromatography with Sulfur Chemiluminescence Detection.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/09//
VL - 15
IS - 9
M3 - Article
SP - 695
EP - 704
SN - 1047322X
AB - As part of a collaborative project between the National Institute for Occupational Safety and Health and the Federal Highway Administration to evaluate asphalt pavers' exposures to asphalt fume and their potential health effects, a method was developed for the determination of total sulfur compounds and benzothiazole in asphalt fume samples. Asphalt fume samples were collected from asphalt mixtures with and without the addition of ground-up rubber tires. The asphalt fume samples were collected with sampling trains that consisted of a Teflon membrane filter and an XAD-2 adsorbent tube. Filter and sampling tube media were extracted with hexane and subsequently analyzed by gas chromatography with a sulfur chemiluminescence detector. Separation was achieved with a 100 percent dimethyl polysiloxane fused silica column. Typical calibration curves had linear correlation coefficients of 0.99 or better with a relative standard deviation (RSD) of 5 percent. Benzothiazole desorption efficiency (DE) determined using spiked sampling tubes ranged from 96.5 percent at 5.0 μg to 89.4 percent at 40 μg with RSD values from 0.9 to 4.0 percent. Benzothiazole storage recovery determined using sampling tubes spiked at 20 μg and refrigerated for 30 days at 4°C was 89.8 percent when corrected for the DE with an RSD of 1.1 percent. The limit of detection for the method determined using spiked sampling tubes was 0.30 μg. Quantitation for total sulfur compounds and benzothiazole was against benzothiazole standards in hexane. Because of detector selectivity, sample preparation consisted of a simple hexane extraction even when samples had a high background due to hydrocarbon overload. Detector sensitivity provided quantitation in the sub-microgram region. Because of the sample preparation step and because benzothiazole was determined during the same analysis run, this method is straightforward and analytically efficient. The method has been used to analyze asphalt fume samples collected at several asphalt paving and roof operations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SULFUR compounds
KW - BENZOTHIAZINE
KW - ASPHALT pavements
KW - ANALYTICAL METHODS DEVELOPMENT
KW - Asphalt fume
KW - benzothiazole
KW - Chemiluminescence
KW - Construction
KW - GAS CHROMATOGRAPHY
KW - ORGANIC SULFUR-CONTAINING COMPOUNDS
N1 - Accession Number: 3969715; Jaycox, Larry B. 1 Olsen, Larry D. 1; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Sep2000, Vol. 15 Issue 9, p695; Subject Term: SULFUR compounds; Subject Term: BENZOTHIAZINE; Subject Term: ASPHALT pavements; Author-Supplied Keyword: ANALYTICAL METHODS DEVELOPMENT; Author-Supplied Keyword: Asphalt fume; Author-Supplied Keyword: benzothiazole; Author-Supplied Keyword: Chemiluminescence; Author-Supplied Keyword: Construction; Author-Supplied Keyword: GAS CHROMATOGRAPHY; Author-Supplied Keyword: ORGANIC SULFUR-CONTAINING COMPOUNDS; NAICS/Industry Codes: 324121 Asphalt Paving Mixture and Block Manufacturing; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10473220050110112
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huttin, C.
AU - Moeller, J.F.
AU - Stafford, R.S.
T1 - Patterns and Costs for Hypertension Treatment in the United States: Clinical, Lifestyle and Socioeconomic Predictors from the 1987 National Medical Expenditures Survey.
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
Y1 - 2000/09//
VL - 20
IS - 3
M3 - Article
SP - 181
EP - 195
PB - Springer Science & Business Media B.V.
SN - 11732563
AB - Objective: To estimate the impact of clinical and non-clinical predictors of patterns of medication use and expenditures for the treatment of hypertension in the USA. Data Sources: The 1987 National Medical Expenditures Survey was used to identify 6398 individuals with hypertension over the age of 18 years. Pharmacological treatment was identified through patient self-reports of antihypertensive medications. Study Design: This retrospective, cross-sectional study used a multivariate two-stage decision model to estimate the demand for antihypertensive medications conditional on receipt of at least one antihypertensive prescription drug. Results: Women and the elderly were more likely to obtain medications and had greater expenditures on antihypertensive medications. Privately insured patients were 59% (if non-elderly) or 163% (if elderly with Medicare) more likely to receive drug therapy than uninsured patients. Patients with only Medicaid coverage were 126% more likely to receive drug therapy than uninsured patients. Compared with patients characterised as lower risk-takers, very high and high risk-takers were 38% and 24% less likely to be on drug therapy, respectively. Black, non-Hispanics were 30% more likely to be on drug therapy than White, non-Hispanics, but had lower annual expenditures on antihypertensive drugs. Severely overweight individuals [bodymass index (BMI) >30] were 62% more likely than patients with a BMI <27 to be on drug therapy and also had higher drug expenditures. Conclusions: Insurance had a more striking effect on access to antihypertensive drug therapy than on patterns of drug use or expenditures. Race/ethnicity and patient attitudes towards risk were important determinants of access to antihypertensive drug therapies, as well as patterns of drug use and expenditures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Drug Investigation is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTENSION -- Treatment
KW - ANTIHYPERTENSIVE agents
KW - MEDICAL care costs
KW - UNITED States
KW - Antihypertensives, therapeutic use
KW - Cost analysis
KW - Health services accessibility
KW - Hypertension, treatment
KW - Pharmacoeconomics
KW - Reimbursement
N1 - Accession Number: 9523113; Huttin, C. 1 Moeller, J.F. 2 Stafford, R.S. 3; Affiliation: 1: Faculty of Economics, Business Department, University of Paris X, Paris, France 2: Agency for Healthcare Research and Quality, Center for Cost and Financing Studies, Rockville, Maryland, USA 3: Partners/Massachusetts General Hospital, Institute for Health Policy, Boston, Massachusetts, USA; Source Info: 2000, Vol. 20 Issue 3, p181; Subject Term: HYPERTENSION -- Treatment; Subject Term: ANTIHYPERTENSIVE agents; Subject Term: MEDICAL care costs; Subject Term: UNITED States; Author-Supplied Keyword: Antihypertensives, therapeutic use; Author-Supplied Keyword: Cost analysis; Author-Supplied Keyword: Health services accessibility; Author-Supplied Keyword: Hypertension, treatment; Author-Supplied Keyword: Pharmacoeconomics; Author-Supplied Keyword: Reimbursement; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RITH-NAJARIAN, STEPHEN
AU - GOHDES, DOROTHY
AU - MCGRATH, NICOLE M.
AU - CURRAN, BRONWYN A.
T1 - Preventing Amputations Among Patients With Diabetes on Dialysis.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2000/09//
VL - 23
IS - 9
M3 - Article
SP - 1445
EP - 1446
SN - 01495992
N1 - Accession Number: 96717261; RITH-NAJARIAN, STEPHEN 1; Email Address: srithnajarian@nchs.com GOHDES, DOROTHY MCGRATH, NICOLE M. 2; Email Address: nicole@nhl.co.nz CURRAN, BRONWYN A. 2; Affiliation: 1: Indian Health Service, Bemidji 2: Northland Diabetes Service, Whangarei Hospital, Whangarei, New Zealand; Source Info: Sep2000, Vol. 23 Issue 9, p1445; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Royce, M.E.
AU - Hoff, P.M.
AU - Pazdur, R.
T1 - Progress in Colorectal Cancer Chemotherapy: How Far Have We Come, How Far to Go?
JO - Drugs & Aging
JF - Drugs & Aging
Y1 - 2000/09//
VL - 17
IS - 3
M3 - Article
SP - 201
EP - 216
PB - Springer Science & Business Media B.V.
SN - 1170229X
AB - Fluorouracil has been the mainstay of treatment for colorectal cancer (CRC) for almost 40 years. Various schedules and biochemical modulators have been investigated in an attempt to improve the therapeutic efficacy of fluorouracil. To date, fluorouracil plus folinic acid represents the standard therapy in CRC for the adjuvant treatment of patients at high risk for relapse and for the first-line treatment of metastatic disease. Combination chemotherapy regimens have not been developed due to the lack of other active agents. However, the availability of several novel agents now allows investigation of combination regimens in this disease. One group of such agents, the oral fluoropyrimidines (tegafur/uracil plus oral folinic acid, capecitabine, eniluracil plus oral fluorouracil, and tegafur/gimeracil/potassium oxonate), are convenient oral alternatives to intravenous fluorouracil. A particular advantage of these oral agents is the reduction in the incidence of febrile neutropenia and mucositis compared with fluorouracil given in an intravenous bolus schedule. To gain clinical acceptance, however, oral fluoropyrimidines must confer at least the same survival advantages associated with the optimal intravenous fluorouracil regimens. Irinotecan and oxaliplatin are 2 other novel agents that have mechanisms of action that are uniquely different from those of fluorouracil, with demonstrated activity in patients with fluorouracil-refractory disease. Recent randomised trials comparing fluorouracil plus folinic acid with combinations of either irinotecan or oxaliplatin and fluorouracil plus folinic acid have shown that response rates are improved and time to progression is increased in patients receiving the combination regimens. These regimens are being rapidly introduced in the adjuvant setting, and the role and acceptance of these combination regimens as first-line therapy needs to be defined. Other novel agents being evaluated in the treatment of patients with advanced CRC include oral edrecolomab (monoclonal antibody 17-1A) and tumour vaccines. Future research is focused on enabling clinicians to individualise treatment strategies in patients with CRC, so as to improve clinical outcomes and reduce drug toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drugs & Aging is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer -- Treatment
KW - DRUG therapy
KW - FLUOROURACIL
KW - THERAPEUTIC use
KW - Antimetabolites, therapeutic use
KW - Antineoplastics, therapeutic use
KW - BCG, therapeutic use
KW - Capecitabine, therapeutic use
KW - Colorectal cancer, treatment
KW - Edrecolomab, therapeutic use
KW - Eniluracil, therapeutic use
KW - Fluorouracil, therapeutic use
KW - Immunomodulators, therapeutic use
KW - Irinotecan, therapeutic use
KW - Oxaliplatin, therapeutic use
KW - Raltitrexed, therapeutic use
KW - Research and development
KW - S 1, therapeutic use
KW - Tegafur/uracil, therapeutic use
N1 - Accession Number: 9526434; Royce, M.E. 1 Hoff, P.M. 2 Pazdur, R. 3; Affiliation: 1: University of Texas, M. D. Anderson Cancer Center, Division of Medicine, Houston, Texas, USA 2: University of Texas M. D. Anderson Cancer Center, Department of GI Oncology and Digestive Diseases, Houston, Texas, USA 3: Division of Oncology Products, Center for Drug Evaluation and Treatment, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2000, Vol. 17 Issue 3, p201; Subject Term: COLON cancer -- Treatment; Subject Term: DRUG therapy; Subject Term: FLUOROURACIL; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Antimetabolites, therapeutic use; Author-Supplied Keyword: Antineoplastics, therapeutic use; Author-Supplied Keyword: BCG, therapeutic use; Author-Supplied Keyword: Capecitabine, therapeutic use; Author-Supplied Keyword: Colorectal cancer, treatment; Author-Supplied Keyword: Edrecolomab, therapeutic use; Author-Supplied Keyword: Eniluracil, therapeutic use; Author-Supplied Keyword: Fluorouracil, therapeutic use; Author-Supplied Keyword: Immunomodulators, therapeutic use; Author-Supplied Keyword: Irinotecan, therapeutic use; Author-Supplied Keyword: Oxaliplatin, therapeutic use; Author-Supplied Keyword: Raltitrexed, therapeutic use; Author-Supplied Keyword: Research and development; Author-Supplied Keyword: S 1, therapeutic use; Author-Supplied Keyword: Tegafur/uracil, therapeutic use; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chernew, Michael E.
AU - Encinosa, William E.
AU - Hirth, Richard A.
T1 - Optimal health insurance: the case of observable, severe illness.
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2000/09//
VL - 19
IS - 5
M3 - Article
SP - 585
EP - 609
SN - 01676296
AB - We explore optimal cost-sharing provisions for insurance contracts when individuals have observable, severe diseases with a discrete number of medically appropriate treatment options. Variation in preferences for alternative treatments is unobserved by the insurer and non-contractible. Interest in such situations is increasingly common, exemplified by disease cane-out programs and shared decision-making (SDM) tools. We demonstrate that optimal insurance charges a copay to patients choosing the high-cost treatment and provides consumers of the low-cost treatment a cash payment. A simulation of the effect of such a policy, based on prostate cancer, indicates a substantial reduction in moral hazard. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE
KW - HEALTH insurance
KW - THERAPEUTICS
KW - CONTRACTS
KW - COST
KW - INSURANCE companies
KW - PAYMENT
KW - PERSONS
KW - Health insurance
KW - Moral hazard
KW - Treatment-specific copayments
N1 - Accession Number: 11945410; Chernew, Michael E. 1; Email Address: mchernew@sph.umich.edu Encinosa, William E. 2 Hirth, Richard A. 3; Affiliation: 1: Department of Health Management and Policy, University of Michigan, and NBER, 109 Observatory Drive, Ann Arbor, MI 48109, USA. 2: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, USA. 3: Department of Health Management and Policy, University of Michigan, MI, USA.; Source Info: Sep2000, Vol. 19 Issue 5, p585; Subject Term: INSURANCE; Subject Term: HEALTH insurance; Subject Term: THERAPEUTICS; Subject Term: CONTRACTS; Subject Term: COST; Subject Term: INSURANCE companies; Subject Term: PAYMENT; Subject Term: PERSONS; Author-Supplied Keyword: Health insurance; Author-Supplied Keyword: Moral hazard; Author-Supplied Keyword: Treatment-specific copayments; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524210 Insurance Agencies and Brokerages; NAICS/Industry Codes: 524128 Other Direct Insurance (except Life, Health, and Medical) Carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524114 Direct Health and Medical Insurance Carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stiffman, Arlene
AU - Hadley-Ives, Eric
AU - Doré, Peter
AU - Polgar, Michael
AU - Horvath, Violet
AU - Striley, Catherine
AU - Elze, Diane
T1 - Youths' Access to Mental Health Services: The Role of Providers' Training, Resource Connectivity, and Assessment of Need.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2000/09//
VL - 2
IS - 3
M3 - Article
SP - 141
EP - 154
SN - 15223434
AB - This paper posits that providers with training in and knowledge of mental health resources are more likely to recognize youths' mental health problems, and provide youths with services. In 1994 and 1996, we interviewed 792 adolescents who were involved with St. Louis public health, juvenile justice, child welfare, or education service sectors. Two hundred eighty-two youths had received some services, listing 533 providers. We could identify 364 of those providers, and 61% (222) responded concerning service need, service use, and provider knowledge and behavior. Structural equation models demonstrate that provider assessment of youths' mental health problems is the largest and provider knowledge of service resources the second largest determinant of service provision. Youths' self-reported mental health is not positively associated with increased services and is only minimally associated with provider assessment of their problems. Training (both professional and inservice) contributes to higher assessments of youths' problems and greater resource knowledge, which is associated with increased service provision. Providers from the mental health and child welfare sectors have more professional training in mental health and are more likely to receive inservice training. Inservice training should be offered to all who work with youths. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health services
KW - TEENAGERS -- Health
KW - STRESS management for teenagers
KW - MENTAL health
KW - PATHOLOGICAL psychology
KW - YOUTH
KW - adolescents
KW - assessment
KW - mental health services
KW - service access
KW - service provision
N1 - Accession Number: 50189243; Stiffman, Arlene 1; Email Address: arstiff@gwbmail.wustl.edu Hadley-Ives, Eric 1 Doré, Peter 1 Polgar, Michael 1 Horvath, Violet 1 Striley, Catherine 1 Elze, Diane 1; Affiliation: 1: George Warren Brown School of Social Work, Center for Mental Health Services, Washington University in St. Louis, USA; Source Info: Sep2000, Vol. 2 Issue 3, p141; Subject Term: MENTAL health services; Subject Term: TEENAGERS -- Health; Subject Term: STRESS management for teenagers; Subject Term: MENTAL health; Subject Term: PATHOLOGICAL psychology; Subject Term: YOUTH; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: assessment; Author-Supplied Keyword: mental health services; Author-Supplied Keyword: service access; Author-Supplied Keyword: service provision; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 14p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1023/A:1010189710028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, A.A.
AU - Kisin, E.
AU - Kisin, J.
AU - Castranova, V.
AU - Kommineni, C.
T1 - Elevated oxidative stress in skin of B6C3F1 mice affects dermal exposure to metal working fluid.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2000/09//
VL - 16
IS - 7/8
M3 - Article
SP - 267
EP - 276
PB - Sage Publications, Ltd.
SN - 07482337
AB - Metal working fluids (MWFs) are widely used in industry for metal cutting, drilling, shaping, lubricating, and milling. Potential for dermal exposure to MWFs exists for a large number of men and women via aerosols and splashing during the machining operations. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we showed that dermal exposure of female and male B6C3F1 mice to 5% MWFs for 3 months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWF also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate the interaction between oxidative stress in the skin and topical application of MWF. Oxidative stress in skin of B6C3F1 mice of both sexes was generated by intradermal injection of the hydrogen peroxide (H[sub 2]O[sub 2])-producing enzyme, glucose oxidase with polyethylene glycol (GOD+PEG). In mice given GOD+PEG, topical treatment with MWF (200 μl, 30%, for 1, 3, or 7 days) resulted in a mixed inflammatory cell response, accumulation of peroxidative products, and reduction of GSH content in the skin. Such changes were not observed with MWF treatment alone. These data indicate that oxidative stress can enhance dermal inflammation caused by occupational exposure to MWF. Toxicology and Industrial Health (2000) 16, 267–276. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - METALWORK
KW - STRESS (Physiology)
KW - OXIDASES
KW - INDUSTRIAL hygiene
KW - HEALTH
KW - glucose oxidase
KW - GSH
KW - inflammation
KW - Metal working fluid
KW - oxidative stress
KW - skin
N1 - Accession Number: 6398495; Shvedova, A.A. 1 Kisin, E. 1 Kisin, J. 1 Castranova, V. 1 Kommineni, C. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia 26505; Source Info: 2000, Vol. 16 Issue 7/8, p267; Subject Term: SKIN -- Inflammation; Subject Term: METALWORK; Subject Term: STRESS (Physiology); Subject Term: OXIDASES; Subject Term: INDUSTRIAL hygiene; Subject Term: HEALTH; Author-Supplied Keyword: glucose oxidase; Author-Supplied Keyword: GSH; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: Metal working fluid; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: skin; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burns, Ilene T.
AU - Jimmerman, Richard Kent
T1 - Haemophilus Influenzae Type B Disease, Vaccines, and Care of Exposed Individuals.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S7
EP - S14
PB - Frontline Medical Communications
SN - 00943509
AB - Before effective vaccines became available, aporoximately 1 in every 200 children aged younger than 5 years had invasive Haemophilus infiuenzae type b (Hib) disease. Hib was the most common cause cf bacterial meningitis and other invasive Dacterial diseases in this age group. Rapid diagnosis and treatment are essential for Hib meningitis, because the mortality rate is 2% to 5%, even with antibiotic treatment-usually a third-generator cephalosporin, such as cefotaxime or ceftriaxone. Because of the use of Hib vaccines, the incidence of invasive H influenzae disease in children younger thar 5 years old declined by 97% between 1987 and 1997. Recent data indicate that the conjugate Hib vaccines given in infancy can be used interchangeably. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAEMOPHILUS influenzae
KW - BACTERIAL diseases
KW - MENINGITIS in children
KW - INFLUENZA -- Vaccination
KW - VACCINATION of infants
KW - CEFOTAXIME
KW - PEDIATRIC diagnosis
KW - PEDIATRIC therapy
KW - Haemophilus influenzae
KW - Haemophilus vaccines
KW - Haemophilus.
KW - Hoemophilus influenzae
KW - maningitis
KW - meningitis, Haemophilus
N1 - Accession Number: 3842252; Burns, Ilene T. Jimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu; Affiliation: 1: Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine. 2: Department of Health and Human Services, the United States Public Health Service, the Centers for Disease control and Prevention.; Source Info: Sep2000 Vaccines, Vol. 49 Issue 9, pS7; Subject Term: HAEMOPHILUS influenzae; Subject Term: BACTERIAL diseases; Subject Term: MENINGITIS in children; Subject Term: INFLUENZA -- Vaccination; Subject Term: VACCINATION of infants; Subject Term: CEFOTAXIME; Subject Term: PEDIATRIC diagnosis; Subject Term: PEDIATRIC therapy; Author-Supplied Keyword: Haemophilus influenzae; Author-Supplied Keyword: Haemophilus vaccines; Author-Supplied Keyword: Haemophilus.; Author-Supplied Keyword: Hoemophilus influenzae; Author-Supplied Keyword: maningitis; Author-Supplied Keyword: meningitis, Haemophilus; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimmerman, Richard Kent
AU - Burns, Ilene T.
T1 - Child Vaccination, Part 1: Routine Vaccines.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S22
EP - S33
PB - Frontline Medical Communications
SN - 00943509
AB - Despite the success of the national childhood vaccination program in the United States in decreasing mortality due to vaccine-preventable diseases, vaccination rates remain suboptimal. Contributing factors include the failure to appreciate the hazards of vaccine-preventable diseases, concerns about adverse reactions associated with vaccine administration, and missed opportunities to administer vaccines. The 2 major types of indications for vaccinating children are age and presence of a medical condition that increases the risk of a vaccine-preventable disease. Hepatitis B virus (HBV) infection becomes chronic in 90% of those infected as infants, and 25% of those so infected will die of related chronic liver disease as adults. Routine infant vaccination against hepatitis B has been recommended since 1991. Approximately 69% of infants who develop portussis require hospitalization. Acelluar pertussis vaccines have been licensed for use in infancy. Starting in 2000, the all-inactivated poliovirus vaccine (IPV) schedule is recommended. IPV should eliminate vaccine-associated paralytic poliomyelitis Pneumococcal conjugate vaccine was licensed in 2000 for routine use on a schedule of 2,4, 6, and 12 to 15 months. The first dose of measles-mumps-rubella vaccine is now recommended at age 12 to 15 months, simultaneous with varicella vaccine administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION of children
KW - IMMUNIZATION of children
KW - MORTALITY
KW - COMMUNICABLE diseases -- Prevention
KW - HEPATITIS B
KW - MMR vaccine
KW - VIRAL vaccines
KW - VACCINATION of infants
KW - measles vaccine
KW - pertussis vaccine
KW - pneumococcal conjugate vaccine [non-MESHI]
KW - poliovirus vaccine
KW - Vaccination
KW - varicella vaccine [non-MESH]
KW - viral hepatitis vaccines
N1 - Accession Number: 3842254; Zimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu*1 Burns, Ilene T.; Affiliation: 1: Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh, School of Medicine. 2: Department of Health and Human Services, the US Public Health Service, the CDC.; Source Info: Sep2000 Vaccines, Vol. 49 Issue 9, pS22; Subject Term: VACCINATION of children; Subject Term: IMMUNIZATION of children; Subject Term: MORTALITY; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: HEPATITIS B; Subject Term: MMR vaccine; Subject Term: VIRAL vaccines; Subject Term: VACCINATION of infants; Author-Supplied Keyword: measles vaccine; Author-Supplied Keyword: pertussis vaccine; Author-Supplied Keyword: pneumococcal conjugate vaccine [non-MESHI]; Author-Supplied Keyword: poliovirus vaccine; Author-Supplied Keyword: Vaccination; Author-Supplied Keyword: varicella vaccine [non-MESH]; Author-Supplied Keyword: viral hepatitis vaccines; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimmerman, Richard Kent
AU - Burns, Ilene T.
T1 - Child Vaccination, Part 2.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/09/02/Sep2000 Vaccines
VL - 49
IS - 9
M3 - Article
SP - S34
EP - S40
PB - Frontline Medical Communications
SN - 00943509
AB - The 1996, the Advisory Committee on immunization Practices (ACIP), the American Academy of Family Physicians (AAFP), the American Academy of Pediatrics (AAP), and the American Medical Association recommended a well-child office visit at age 11 to 12 years to check vaccination Status. Vaccination status should be assessed for varicella, hepatitis B. the second dose of measles-mumps-rubella (MMR) vaccine, and tetanus-diptheria (Td) toxoid if not giver in the past 5 years. Adolescent patterns should be screened for high-risk conditions indicating the need for influenza, pneumococcal, or hepatitis A vaccines. The Accelerated immunization Schedule and Minimal Interval Table should be consulted for children who are behind schedule. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - VACCINATION of children
KW - MMR vaccine
KW - INFLUENZA -- Vaccination
KW - VIRAL vaccines
KW - hepatitis B vaccines
KW - influenza vaccine
KW - measles
KW - measles, mumps, rubella vaccine [non-MESH]
KW - mumps
KW - pneumococcal polysaccharide vaccine [non- MESH]
KW - pneumococcal polysaccharide vaccine [non-MESH]
KW - rubella vaccine [non-MESH]
KW - Vaccination
KW - varicella vaccine [non-MESH]
KW - varicella vaccine [non-MESH].
KW - AMERICAN Medical Association
KW - AMERICAN Academy of Family Physicians
N1 - Accession Number: 3842255; Zimmerman, Richard Kent 1,2; Email Address: zimmer+@pitt.edu Burns, Ilene T.; Affiliation: 1: Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine. 2: Department of Health and Human Services, the US Public Health Service, the Centers for Disease Control and Prevention.; Source Info: Sep2000 Vaccines, Vol. 49 Issue 9, pS34; Subject Term: IMMUNIZATION; Subject Term: VACCINATION of children; Subject Term: MMR vaccine; Subject Term: INFLUENZA -- Vaccination; Subject Term: VIRAL vaccines; Author-Supplied Keyword: hepatitis B vaccines; Author-Supplied Keyword: influenza vaccine; Author-Supplied Keyword: measles; Author-Supplied Keyword: measles, mumps, rubella vaccine [non-MESH]; Author-Supplied Keyword: mumps; Author-Supplied Keyword: pneumococcal polysaccharide vaccine [non- MESH]; Author-Supplied Keyword: pneumococcal polysaccharide vaccine [non-MESH]; Author-Supplied Keyword: rubella vaccine [non-MESH]; Author-Supplied Keyword: Vaccination; Author-Supplied Keyword: varicella vaccine [non-MESH]; Author-Supplied Keyword: varicella vaccine [non-MESH].; Company/Entity: AMERICAN Medical Association DUNS Number: 805631447 Company/Entity: AMERICAN Academy of Family Physicians DUNS Number: 010648921; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Margaret Ann
T1 - Historical Perspective on the Regulation of Antimicrobial Residues in Food in the United States.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 8
EP - 10
PB - Co-Action Publishing
SN - 0891060X
AB - Presents the historical perspective on the regulation of antimicrobial residues in food in the United States. Entities of veterinary drug regulation; Assessment of food safety; Evaluation of antimicrobial residues.
KW - VETERINARY drug residues
KW - FOOD handling
KW - UNITED States
N1 - Accession Number: 4229993; Miller, Margaret Ann 1; Affiliation: 1: From the Office of Women's Health, US Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p8; Subject Term: VETERINARY drug residues; Subject Term: FOOD handling; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/08910600050216066
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bartholomew, Mary J.
T1 - Microbiological Safety of Drug Residues in Food — Workshop Objectives.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 13
EP - 14
PB - Co-Action Publishing
SN - 0891060X
AB - Presents workshop on microbiological safety of drug residues in food by Center for Veterinary Medicine. Goal of the workshop; Significance of microbiological endpoints; Experiences of microbiologists.
KW - CONFERENCES & conventions
KW - VETERINARY drug residues
KW - FOOD -- Microbiology -- Congresses
N1 - Accession Number: 4229991; Bartholomew, Mary J. 1; Affiliation: 1: From the Center for Veterinary Medicine, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p13; Subject Term: CONFERENCES & conventions; Subject Term: VETERINARY drug residues; Subject Term: FOOD -- Microbiology -- Congresses; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 2p; Document Type: Article
L3 - 10.1080/08910600050216084
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cerniglia, Carl E.
T1 - The JECFA and Alternate Approaches for Determining ADIs for Antimicrobial Residues.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 30
EP - 34
PB - Co-Action Publishing
SN - 0891060X
AB - Focuses on the FAO/WHO Joint Expert Committee on Food Additives (JECFA) and its approaches in determining acceptable daily intake (ADI) for antimicrobial residues. Tasks of JECFA; Types of antimicrobial studies for ADI establishment; Effect of the veterinary drug residue on the human intestinal microflora.
KW - COMMITTEES
KW - VETERINARY drug residues
KW - GASTROINTESTINAL system -- Microbiology
KW - ADVERSE MICROBIOLOGICAL EFFECTS
KW - Drug residues
KW - Intestinal microflora
KW - JECFA
KW - VETERINARY ANTIMICROBIALS
N1 - Accession Number: 4229999; Cerniglia, Carl E. 1; Affiliation: 1: From the National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p30; Subject Term: COMMITTEES; Subject Term: VETERINARY drug residues; Subject Term: GASTROINTESTINAL system -- Microbiology; Author-Supplied Keyword: ADVERSE MICROBIOLOGICAL EFFECTS; Author-Supplied Keyword: Drug residues; Author-Supplied Keyword: Intestinal microflora; Author-Supplied Keyword: JECFA; Author-Supplied Keyword: VETERINARY ANTIMICROBIALS; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/08910600050216138
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fernández, A. Haydée
T1 - FDA Proposal for Establishing Microbiological Acceptable Daily Intakes for Antimicrobial Residues.
JO - Microbial Ecology in Health & Disease
JF - Microbial Ecology in Health & Disease
Y1 - 2000/09/02/Sep2000 Supplement 1
VL - 12
IS - 3
M3 - Article
SP - 42
EP - 44
PB - Co-Action Publishing
SN - 0891060X
AB - Focuses on the establishment of a threshold acceptable daily intake (ADI) for antimicrobial residues by the United States Food and Drug Administration. Basis of ADI threshold; Impact of the residues on the intestinal microflora; Conditions for an antimicrobial drug.
KW - VETERINARY drug residues
KW - ANTI-infective agents
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 4229996; Fernández, A. Haydée 1; Affiliation: 1: From the Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Sep2000 Supplement 1, Vol. 12 Issue 3, p42; Subject Term: VETERINARY drug residues; Subject Term: ANTI-infective agents; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1080/08910600050216165
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cecala, Andrew B.
AU - Timko, Robert J.
AU - Thimons, Edward D.
T1 - Methods to Lower the Dust Exposure of Bag Machine Operators and Bag Stackers.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/10//
VL - 15
IS - 10
M3 - Article
SP - 751
EP - 765
SN - 1047322X
AB - This article reviews various dust control technologies developed over the years at the Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH) to provide various options and alternatives to lower bag machine operators' and bag stackers' dust exposures. Dust exposure records for the past 20 years show that bag machine operators and bag stackers normally have the highest respirable dust exposures of workers at mineral processing plants. A substantial amount of research has been performed over the years to minimize the dust exposure to these workers and the intent is to present all this information together in one article. Most of the research describes engineering controls that were adapted to existing facilities to reduce the dust generated during bag filling, bag conveying, and bag stacking. In some cases, a single technique succeeded in lowering respirable dust concentrations for all three processes, thus reducing the dust exposure to both the bag machine operator and the bag stacker. In other cases, a technique was developed to specifically reduce the dust exposure of one process or the other.This research also reviews various controls for secondary dust exposure, including general ventilation requirements to mill buildings, the effects of background dust sources, and personal work practices. This information is presented to help industrial hygienists, plant managers, engineers, and workers lower the dust exposure of bag machine operators and bag stackers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DUST control
KW - SILICA
KW - HEALTH
KW - PENNSYLVANIA
KW - PITTSBURGH (Pa.)
KW - UNITED States
KW - BAG OPERATOR
KW - BAG STACKER
KW - Dust control
KW - Dust exposure
KW - Mineral processing
KW - Respirable dust
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 3961938; Cecala, Andrew B. 1 Timko, Robert J. 1 Thimons, Edward D. 1; Affiliation: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; Source Info: Oct2000, Vol. 15 Issue 10, p751; Subject Term: DUST control; Subject Term: SILICA; Subject Term: HEALTH; Subject Term: PENNSYLVANIA; Subject Term: PITTSBURGH (Pa.); Subject Term: UNITED States; Author-Supplied Keyword: BAG OPERATOR; Author-Supplied Keyword: BAG STACKER; Author-Supplied Keyword: Dust control; Author-Supplied Keyword: Dust exposure; Author-Supplied Keyword: Mineral processing; Author-Supplied Keyword: Respirable dust; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 15p; Illustrations: 2 Black and White Photographs, 4 Diagrams, 3 Charts, 10 Graphs; Document Type: Article
L3 - 10.1080/10473220050129392
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petsonk, Edward L.
AU - Mei Lin Wang, Edward L.
AU - Lewis, Daniel M.
AU - Siegel, Paul D.
AU - Husberg, Bradley J.
T1 - Asthma-Like Symptoms in Wood Product Plant Workers Exposed to Methylene Diphenyl Diisocyanate.
JO - CHEST
JF - CHEST
Y1 - 2000/10//
VL - 118
IS - 4
M3 - Article
SP - 1183
PB - American College of Chest Physicians
SN - 00123692
AB - Background: Diisocyanates, a group of highly reactive chemicals, have frequently been associated with occupational asthma. We evaluated respiratory health in workers at a new wood products manufacturing plant that uses methylene diphenyl diisocyanate (MDI), and was designed and operated with a goal of minimizing worker exposures. Methods: Health surveys using standardized respiratory questionnaires were done prior to the initial use of diisocyanates in the plant, and semiannually thereafter for a period of 2 years. Other testing included occupational and work practice histories, serial peak flow measurements, spirometry, methacholine challenge, and measurement of specific IgE antibodies to MDI-albumin conjugate. Results: Of 214 plant employees who participated in at least one health survey, a follow-up survey was also available from 178 employees (83%). New-onset asthma-like symptoms (NAS) were reported by 15 of 56 workers (27%) in areas with the highest potential for exposures to liquid MDI monomer and prepolymer, vs 0 of 43 workers in the lowest potential exposure areas (p = 0.001). In the areas with high potential exposure, NAS developed in 47% of workers who had noted MDI skin staining, vs 19% without skin stains (p = 0.07). Working around and cleaning up liquid MDI represented a significant risk for asthma-like symptoms in both current smokers and nonsmokers; work with finished wood products did not. Asthma-like symptoms were associated with variable airflow limitation (odds ratio [OR], 5.0; confidence interval ICI], 1.4 to 18.7) and specific IgE to MDI-albumin (OR, 3.2; CI, 1.1 to 9.0), but not with skin prick tests to common aeroallergens (OR, 1.1; CI, 0.5 to 2.7). Conclusions: During the first 2 years of operation, in a plant designed and operated to control exposure to diisocyanates, the development of asthma-like symptoms was reported in a relatively high proportion of the employees who worked with liquid MDI. To prevent asthma symptoms among workers, careful control of respiratory tract exposures associated with liquid MDI is important, especially during cleanup activities. Strict limitation of skin contact with diisocyanates may also be necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL diseases
KW - LUNG diseases
KW - ISOCYANATES
KW - ASTHMA
N1 - Accession Number: 11005011; Petsonk, Edward L. 1 Mei Lin Wang, Edward L. 1 Lewis, Daniel M. 2 Siegel, Paul D. 2 Husberg, Bradley J. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, WV 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, WV; Source Info: Oct2000, Vol. 118 Issue 4, p1183; Subject Term: OCCUPATIONAL diseases; Subject Term: LUNG diseases; Subject Term: ISOCYANATES; Subject Term: ASTHMA; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 11p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawn, S. D.
AU - Rudolph, D.
AU - Wiktor, S.
AU - Coulibaly, D.
AU - Ackah, A.
AU - Lal, R. B.
T1 - Tuberculosis (TB) and HIV infection are independently associated with elevated serum concentrations of tumour necrosis factor receptor type 1 and β2-microglobulin, respectively.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2000/10//
VL - 122
IS - 1
M3 - Article
SP - 79
EP - 84
PB - Wiley-Blackwell
SN - 00099104
AB - The aim of this study was to identify immune markers that are independently associated with HIV infection or TB in vivo. Using commercially available assays, we measured concentrations of five immune markers in sera from 175 out-patients attending medical clinics in Cote D'Ivoire and Ghana, West Africa. Patients were categorized into groups with TB only (TB+HIV-, n = 55), TB and HIV co-infection (TB+HIV+, n = 50), HIV infection only (TB-HIV+, n = 35), or neither infection (TB-HIV-, n = 35). TB+HIV+ and TB-HIV+ groups were matched for blood CD4+ lymphocyte count. Mean ± s.d. concentrations of β2-microglobulin were similarly increased in both the TB-HIV+ (5·3 ± 2·1 μg/ml, P < 0·0001) and the TB+HIV+ (5·0 ± 1·5 μg/ml, P < 0·0001) groups compared with the TB-HIV- group (2·2 ± 1·8 μg/ml), but were only slightly increased in the TB+HIV- group (3·2 ± 1·8 μg/ml, P = 0·01). In contrast, mean serum concentrations of soluble tumour necrosis factor receptor type I (sTNF-RI) were similarly elevated in the TB+HIV- (1873 ± 799 pg/ml, P < 0·0001) and TB+HIV+ (1797 ± 571 pg/ml, P < 0·0001) groups compared with uninfected subjects (906 ± 613 pg/ml), but there was only a small increase in sTNF-RI in the TB-HIV+ group (1231 ± 165 pg/ml, P = 0·03). Both TB and HIV infection were associated with substantial elevation of serum concentrations of soluble CD8, soluble CD54, and sTNF-R type II. Analysis of additional samples from groups of TB+HIV- and TB+HIV+ patients receiving anti-TB treatment... [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - TUBERCULOSIS
KW - HIV infections
KW - SERUM
KW - GLOBULINS
KW - β
KW - HIV
KW - immune activation markers
KW - TNF receptors
KW - tuberculosis
N1 - Accession Number: 5465881; Lawn, S. D. 1 Rudolph, D. 1 Wiktor, S. 2 Coulibaly, D. 2 Ackah, A. 2 Lal, R. B. 1; Affiliation: 1: HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA, and 2: Projet Retro-CI and Centres Antituberculeux, Abidjan, Cote D'Ivoire, West Africa; Source Info: Oct2000, Vol. 122 Issue 1, p79; Subject Term: TUMOR necrosis factor; Subject Term: TUBERCULOSIS; Subject Term: HIV infections; Subject Term: SERUM; Subject Term: GLOBULINS; Author-Supplied Keyword: β; Author-Supplied Keyword: HIV; Author-Supplied Keyword: immune activation markers; Author-Supplied Keyword: TNF receptors; Author-Supplied Keyword: tuberculosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2249.2000.01341.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eisenberg, John M.
AU - Power, Elaine J.
AU - Eisenberg, J M
AU - Power, E J
T1 - Transforming insurance coverage into quality health care: voltage drops from potential to delivered quality.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2000/10/25/
VL - 284
IS - 16
M3 - journal article
SP - 2100
EP - 2107
SN - 00987484
AB - Although the US health care system is often touted as one of the best in the world, disparities exist in quality of care received by different populations, in different regions, and across different institutions and clinicians. Initiatives to provide access to health insurance have been a major policy tool to ensure that Americans receive high-quality health care. However, availability of insurance coverage does not automatically lead to high-quality care. This article explores points of vulnerability in the US health care system at which the potential to achieve high-quality care can be lost: (1) access to insurance coverage; (2) enrollment in available insurance plans; (3) access to covered services, clinicians, and health care institutions; (4) choice of plans, clinicians, and health care institutions; (5) access to a consistent source of primary care; (6) access to referral services; and (7) delivery of high-quality health care services. Ensuring high-quality health care requires that each of these "voltage drops" be recognized and addressed. JAMA. 2000;284:2100-2107. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- United States
KW - HEALTH insurance -- United States
KW - NEEDS assessment (Medical care)
KW - QUALITY control
KW - UNITED States
N1 - Accession Number: 3689159; Eisenberg, John M. Power, Elaine J. Eisenberg, J M 1 Power, E J; Affiliation: 1: Agency for Healthcare Research and Quality, Department of Health and Human Services, 2101 E Jefferson St, Rockville, MD 20852, USA; Source Info: 10/25/2000, Vol. 284 Issue 16, p2100; Subject Term: MEDICAL care -- United States; Subject Term: HEALTH insurance -- United States; Subject Term: NEEDS assessment (Medical care); Subject Term: QUALITY control; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 1 Diagram; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morrow-Howell, N. L.
AU - Proctor, E. K.
AU - Rubin, E. H.
AU - Li, H.
AU - Thompson, S.
T1 - Service needs of depressed older adults following acute psychiatric care.
JO - Aging & Mental Health
JF - Aging & Mental Health
Y1 - 2000/11//
VL - 4
IS - 4
M3 - Article
SP - 330
EP - 338
PB - Routledge
SN - 13607863
AB - Older persons with mental disorder need mental health services, but the extent to which they have service needs in other domains (medical, functional and psychosocial) is not established, although these needs may compromise the attainment of psychiatric outcomes. This study focuses on 169 older adults hospitalized for depression and documents their post-acute service needs in four domains: psychiatric, medical, functional and psychosocial. Seventy-five per cent of these psychiatric patients had medical conditions that required treatment. Eighty-four per cent needed assistance with routine activities. Nearly two-thirds (67%) were experiencing one or more psychosocial or environmental problems that warranted intervention. The mean number of service needs was 6.5 (SD=1.5). Fifty-seven per cent had needs in all four domains. Older adults admitted to acute care for depression have high levels of service needs stemming from multiple domains: psychiatric, medical, functional and psychosocial. We extend the biopsychosocial model, largely used to address the origins of psychopathology, to conceptualize the multiple domains of service that older adults with mental disorder need. This biopsychosocial model suggests that needs in each domain should be identified and addressed if desired psychiatric outcomes are to be attained. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aging & Mental Health is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health services
KW - DEPRESSED persons
KW - UNITED States
N1 - Accession Number: 4176421; Morrow-Howell, N. L. 1 Proctor, E. K. 1 Rubin, E. H. 2 Li, H. 3 Thompson, S. 4; Affiliation: 1: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University 2: Department of Psychiatry, Washington University School of Medicine 3: School of Social Work, University of Illinois, Urbana 4: School of Social Work, State University of New York, Buffalo, USA; Source Info: Nov2000, Vol. 4 Issue 4, p330; Subject Term: MENTAL health services; Subject Term: DEPRESSED persons; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6074
L3 - 10.1080/13607860020010484
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weinick, Robin M.
AU - Krauss, Nancy A.
T1 - Racial/Ethnic Differences in Children's Access to Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2000/11//
VL - 90
IS - 11
M3 - Article
SP - 1771
EP - 1774
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study explored reasons for racial and ethnic differences in children's usual sources of care. Methods. Data from the 1996 Medical Expenditure Panel Survey were examined by means of logistic regression techniques. Results. Black and Hispanic children were substantially less likely than White children to have a usual source of care. These differences persisted after control for health insurance and socioeconomic status. Control for language ability, however, eliminated differences between Hispanic and White children. Conclusions. Results suggest that the marked Hispanic disadvantage in children's access to care noted in earlier studies may be related to language ability. (Am d Public Health. 2000;90: 1771-1774) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RACIAL differences
KW - ETHNICITY
KW - CHILD care
KW - SURVEYS
KW - LOGISTIC regression analysis
N1 - Accession Number: 3738283; Weinick, Robin M. 1; Email Address: rweinick@ahrq.gov Krauss, Nancy A. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Md.; Source Info: Nov2000, Vol. 90 Issue 11, p1771; Subject Term: RACIAL differences; Subject Term: ETHNICITY; Subject Term: CHILD care; Subject Term: SURVEYS; Subject Term: LOGISTIC regression analysis; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Yang, Hui-Min
AU - Ma, Jane Y. C.
AU - Roberts, Jenny R.
AU - Barger, Mark W.
AU - Butterworth, Leon
AU - Charron, Tina G.
AU - Castranova, Vince
T1 - Subschronic Silica Exposure Enhances Respiratory Defense Mechanisms and the Pulmonary Clearance of Listeria Monocytogenes in Rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2000/11//
VL - 12
IS - 11
M3 - Article
SP - 1017
EP - 1036
PB - Taylor & Francis Ltd
SN - 08958378
AB - Both Listeria monocytogenes infection and silica exposure have been shown to significantly alter immune responses. In this study, we evaluated the effect of preexposure to silica on lung defense mechanisms using a rat pulmonary L. monocytogenes infection model. Male Sprague-Dawley rats were instilled intratracheally with saline (vehicle control) or silica using either an acute treatment regimen (5 mg/kg; 3 days) or a subchronic treatment protocol (80 mg/kg; 35 days). At 3 or 35 days after silica instillation, the rats were inoculated intratracheally with either ~5000 or 500,000 L. monocytogenes. At 3, 5, and 7 days postinfection, the left lung was removed, homogenized, and cultured on brain heart infusion agar at 37°C. The numbers of viable L. monocytogenes were counted after an overnight incubation. Bronchoalveolar lavage (BAL) was performed on the right lungs, and BAL cell differentials, acellular lactate dehydrogenase (LDH) activity and albumin content were determined. Alveolar macrophage (AM) chemiluminescence (CL) and phagocytosis were assessed as a measure of macrophage function. Lung-associated lymph nodes were removed, and lymphocytes were recovered and differentiated. Preexposure to silica significantly increased the pulmonary clearance of L. monocytogenes as compared to saline controls. Exposure to silica caused significant increases in BAL neutrophils, LDH and albumin, and lymph-nodal T cells and natural killer (NK) cells in infected and noninfected rats. CL and phagocytosis were also elevated in silica-treated rats. In summary, the results demonstrated that exposure of rats to silica enhanced pulmonary immune responses, as evidenced by increases in neutrophils, NK cells, T lymphocytes, and macrophage activation. These elevations in pulmonary immune response are likely responsible for the increase in pulmonary clearance of L. monocytogenes observed with preexposure to silica. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - RESPIRATORY infections
N1 - Accession Number: 3859726; Antonini, James M. 1 Yang, Hui-Min 1 Ma, Jane Y. C. 1 Roberts, Jenny R. 1 Barger, Mark W. 1 Butterworth, Leon 1 Charron, Tina G. 1 Castranova, Vince 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Nov2000, Vol. 12 Issue 11, p1017; Subject Term: SILICA; Subject Term: RESPIRATORY infections; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 20p; Illustrations: 2 Black and White Photographs, 2 Charts, 10 Graphs; Document Type: Article
L3 - 10.1080/08958370050164635
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Marlene R.
AU - McNamara, Robert L.
AU - Segal, Jodi B.
AU - Kim, Nina
AU - Robinson, Karen A.
AU - Goodman, Steven N.
AU - Powe, Neil R.
AU - Bass, Eric B.
T1 - Efficacy of Agents for Pharmacologic Conversion of Atrial Fibrillation and Subsequent Maintenance of Sinus Rhythm.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2000/11//
VL - 49
IS - 11
M3 - Article
SP - 1033
EP - 1046
PB - Frontline Medical Communications
SN - 00943509
AB - CONTEXT Physicians have little evidentiary guidance for pharmacologic agent selection for atrial fibrillation (AF). OBJECTIVE To assess antiarrhythmic agent efficacy for AF conversion and subsequent maintenance of sinus rhythm (MSR). DATA SOURCE We searched the clinical trial database of the Cochrane Collaboration and MEDLINE encompassing literature from 1948 to May 1998. STUDY SELECTION We selected 36 (28%) articles eligible as randomized trials of nonpost-operative AF conversion or MSR in adults. DATA EXTRACTION Study quality; rates of conversion, MSR, and adverse events were extracted. DATA SYNTHESIS Compared with control treatment (placebo, verapamil, diltiazem, or digoxin), the odds ratio (OR) for conversion was greatest for ibutilide/dofetilide (OR=29.1; 95% confidence interval [CI], 9.8-86.1) and flecainide (OR=24.7; 95% CI, 9.0-68.3). Less strong but conclusive evidence existed for propafenone (OR=4.6; 95% CI, 2.6-8.2). Quinidine (OR=2.9; 95% CI, 1.2-7.0) had moderate evidence of efficacy for conversion. Disopyramide (OR=7.0; 95% CI, 0.3-153.0) and amiodarone (OR=5.7; 95% CI, 1.0-33.4) had suggestive evidence of efficacy. Sotalol (OR=0.4; 95% CI, 0.0-3.0) had suggestive evidence of negative efficacy. For MSR, strong evidence of efficacy existed for quinidine (OR=4.1; 95% CI, 2.545.7), disopyramide (OR=3.4; CI, 1.6-7.1), flecainide (OR=3.1; 95 % CI, 1.5-6.2), propafenone (OR=3.7; 95% CI, 2.4-5.7), and sotalol (OR=7.1; 95% CI, 3.8-13.4). The only amiodarone data, from comparison with disopyramide, provided moderate evidence of efficacy for MSR. No trial evaluated procainamide. Direct agent comparisons and adverse event data were limited. CONCLUSIONS Although multiple antiarrhythmic agents had strong evidence of efficacy compared with control treatment for MSR, ibutilide/dofetilide and flecainide had particularly strong evidence of efficacy compared with control treatment for AF conversion. There is sparse and inconclusive evidence on direct agent comparisons and adverse event rates. Obtaining information regarding these relative efficacies should be a research priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATRIAL fibrillation
KW - ATRIAL arrhythmias
KW - PROPAFENONE
KW - MYOCARDIAL depressants
KW - DISOPYRAMIDE
KW - QUINIDINE
KW - anti-arrhythmia agents
KW - Atrial fibrillation
KW - clinical trials
KW - meta-analysis
KW - randomized controlled trials
N1 - Accession Number: 3842268; Miller, Marlene R. 1,2,3; Email Address: mmiller@ahrq.gov McNamara, Robert L. 4,5 Segal, Jodi B. 6 Kim, Nina 7 Robinson, Karen A. 7 Goodman, Steven N. 8 Powe, Neil R. 5,6 Bass, Eric B. 6; Affiliation: 1: Center for Quality, Measurement and Improvement Agency for Healthcare Research and Quality, 2101 East Jefferson Street, Suite 502, Rockville, MD 20852 2: Division of Pediatric Cardiology, Division of Biostatistics, John Hopkins University School of Medicine 3: Graduate Training Program in Clinical Investigation, Johns Hopkins University School of Hygiene and Public Health 4: Division of Cardiology, Division of Biostatistics, John Hopkins University School of Medicine 5: Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health 6: Division of General Internal Medicine, Division of Biostatistics, John Hopkins University School of Medicine 7: Baltimore Cochrane Center, University of Maryland 8: Oncology Center, Division of Biostatistics, John Hopkins University School of Medicine; Source Info: Nov2000, Vol. 49 Issue 11, p1033; Subject Term: ATRIAL fibrillation; Subject Term: ATRIAL arrhythmias; Subject Term: PROPAFENONE; Subject Term: MYOCARDIAL depressants; Subject Term: DISOPYRAMIDE; Subject Term: QUINIDINE; Author-Supplied Keyword: anti-arrhythmia agents; Author-Supplied Keyword: Atrial fibrillation; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: meta-analysis; Author-Supplied Keyword: randomized controlled trials; Number of Pages: 14p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimmerman, M. L.
AU - Friedman, S. L.
T1 - Identification of Rodent Filth Exhibits.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2000/11//Nov/Dec2000
VL - 65
IS - 8
M3 - Article
SP - 1391
EP - 1394
SN - 00221147
AB - Three main types of rodent filth (rodent excreta pellets, gnawing, and nesting material) are described and identification procedures are listed. Suspect excreta pellets that may be encountered in foods from various animals are described in detail and presented in a dichotomous key for comparison and identification. The physical features associated with the excreta pellets (color, shape, size, weight, surface, and matrix composition) are listed for the insects and animals found in the key. Rodent gnawing and rodent nesting materials are defined and the importance of the paired incisor marks, scalloping along edges and the appearance of the building materials are described. The importance of urine, rodent excreta, hairs and/or parasites when defining nesting material, are discussed, along with the key elements used to recognize the gnawing direction by the rodents. Historical data on rodents and health/safety concerns when handling rodent filth exhibits are addressed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RODENTS
KW - IDENTIFICATION
KW - EXHIBITIONS
KW - MAMMALS
KW - URINE
KW - PARASITES
KW - excreta
KW - gnawing
KW - identification
KW - nesting material
KW - rodent
N1 - Accession Number: 28546318; Zimmerman, M. L. 1; Email Address: mzimmerm@ora.fda.gov Friedman, S. L. 2; Affiliation: 1: U.S. Food & Drug Admin., 900 Madison Ave., Baltimore, MD 21201, U.S.A. 2: U.S. Food & Drug Admin., Center for Veterinary Medicine; Source Info: Nov/Dec2000, Vol. 65 Issue 8, p1391; Subject Term: RODENTS; Subject Term: IDENTIFICATION; Subject Term: EXHIBITIONS; Subject Term: MAMMALS; Subject Term: URINE; Subject Term: PARASITES; Author-Supplied Keyword: excreta; Author-Supplied Keyword: gnawing; Author-Supplied Keyword: identification; Author-Supplied Keyword: nesting material; Author-Supplied Keyword: rodent; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - McNamara, Peggy
AU - Caldwell, Blake
AU - Fraser, Irene
AU - De La Mare, Jan
AU - Arent, Jill
T1 - Quality Improvement: New Contributions from the Field of Health Services Research.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 5
EP - 8
SN - 10775587
N1 - Accession Number: 54898118; McNamara, Peggy 1 Caldwell, Blake 2 Fraser, Irene 1 De La Mare, Jan 1 Arent, Jill 3; Affiliation: 1: Agency for Healthcare Research and Quality, Center for Organization and Delivery Studies 2: Centers for Disease Control and Prevention 3: American Association of Health Plans; Source Info: Supplement 2, Vol. 57 Issue S2, p5; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 1443
L3 - 10.1177/107755870005700201
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scanlon, Dennis P.
AU - Rolph, Elizabeth
AU - Darby, Charles
AU - Doty, Hilary E.
T1 - Are Managed Care Plans Organizing for Quality?
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 9
EP - 32
SN - 10775587
AB - This article examines the degree to which managed care organizations (MCOs) are reorganizing to take responsibility for the quality of care and service they provide. Specifically, factors prompting plans to focus on quality improvement (QI) and how they may be building the capacity to improve quality are considered. The authors’ analysis is based on executive interviews with the plan medical directors, QI directors, and chief executive officers (CEOs) in a sample of 24 health plans. The overall response rate was 58.3 percent (medical director = 62.5 percent, QI director = 79.2 percent, CEO = 33.3 percent). The authors queried respondents about (1) perceived drivers and obstacles to the development of an effective QI program, (2) plan organizational structure for QI, and (3) technical capacities for data collection, management, and performance measurement. The results suggest that MCOs are responding to outside pressures to engage in QI. They are reorganizing their management structures and more slowly and tentatively are building technical capacity for QI. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898119; Scanlon, Dennis P. 1 Rolph, Elizabeth 2 Darby, Charles 3 Doty, Hilary E. 1; Affiliation: 1: Pennsylvania State University 2: RAND Corporation 3: Agency for Healthcare Research and Quality and the Center for Quality Measurement and Improvement; Source Info: Supplement 2, Vol. 57 Issue S2, p9; Number of Pages: 24p; Document Type: Article; Full Text Word Count: 9032
L3 - 10.1177/107755870005700202
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fraser, Irene
AU - McNamara, Peggy
T1 - Employers: Quality Takers or Quality Makers?
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 33
EP - 52
SN - 10775587
AB - This article provides a synthesis of past research to help understand the extent to which employers are using their considerable market power to drive health care quality. Are employers quality takers or quality makers? The literature provides some clues about aspects of quality employers are attempting to influence, strategies they are pursuing to influence quality, and their impact. Some employers are interested in some indicators of quality and are incorporating them in a variety of different purchasing strategies. The indicators most frequently used by employers, however, probably are not the ones that clinical experts and policy makers would select as most reflective of clinical quality. It appears that employers as a group are becoming more informed quality takers but are not yet quality makers—with the exception of a few well-resourced outliers. Recent events provide mixed signals about whether the future employer role in influencing quality will diminish, stall, or flourish. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898120; Fraser, Irene 1 McNamara, Peggy 1; Affiliation: 1: Agency for Healthcare Research and Quality, Center for Organization and Delivery Studies; Source Info: Supplement 2, Vol. 57 Issue S2, p33; Number of Pages: 20p; Document Type: Article; Full Text Word Count: 8372
L3 - 10.1177/107755870005700203
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brach, Cindy
AU - Sanches, Linda
AU - Young, Donald
AU - Rodgers, James
AU - Harvey, Holly
AU - McLemore, Thomas
AU - Fraser, Irene
T1 - Wrestling with Typology: Penetrating the “Black Box” of Managed Care by Focusing on Health Care System Characteristics.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2000/11/02/Supplement 2
VL - 57
IS - S2
M3 - Article
SP - 93
EP - 115
SN - 10775587
AB - The health care system has undergone a fundamental transformation undermining the usefulness of the typology of the health maintenance organization, the independent practice association, the preferred provider organization, and so forth. The authors present a new approach to studying the health care system. In matrix form, they have identified a set of organizational and delivery characteristics with the potential to influence outcomes of interest, such as access to services, quality, health status and functioning, and cost. The matrix groups the characteristics by domain—financial features, structure, care delivery and management policies, and products—and by key roles in the health care system—sponsor, plan, provider intermediary organization, and direct services provider. The matrix is a tool for researchers, administrators, clinicians, data collectors, regulators, and other policy makers. It suggests a new set of players to be studied, emphasizes the relationships among the players, and provides a checklist of independent, control, and interactive variables to be included in analyses. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 54898123; Brach, Cindy 1 Sanches, Linda 2 Young, Donald 3 Rodgers, James 4 Harvey, Holly 2 McLemore, Thomas 5 Fraser, Irene 1; Affiliation: 1: Agency for Healthcare Research and Quality, Center for Organization and Delivery Studies 2: Department of Health and Human Services, Office of Assistant Secretary for Planning and Evaluation 3: Health Insurance Association of America 4: American Medical Association 5: National Center for Health Statistics, Division of Health Care Statistics; Source Info: Supplement 2, Vol. 57 Issue S2, p93; Number of Pages: 23p; Document Type: Article; Full Text Word Count: 7966
L3 - 10.1177/107755870005700206
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boundy, Maryanne
AU - Leith, David
AU - Hands, David
AU - Gressel, Michael
AU - Burroughs, G. Edward
T1 - Performance of Industrial Mist Collectors Over Time.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/12//
VL - 15
IS - 12
M3 - Article
SP - 928
EP - 935
SN - 1047322X
AB - Effective, economical control of metalworking fluid mists at the source is important, because exposure to these mists may cause adverse health effects. This study investigated performance changes over time for industrial collectors that removed metalworking fluid mist in the laboratory and in a transmission plant. Aerosizers were used to measure the efficiency of each stage in several multistage collectors as a function of mist droplet diameter, for up to one year of continuous operation. Metal-mesh, first-stage filters operated at low pressure drops and were effective at removing droplets larger than 3 to 5 Θ m in diameter. Some second-stage filters worked better than others. Both ''65 percent'' and ''95 percent'' cartridge filters failed after only a few weeks; their efficiencies decreased substantially over that time. Pocket filters and cylindrical cartridges used as second-stage filters also decreased in efficiency for submicron droplets. Whereas filters for solid particles load continuously to form a dust cake that increases efficiency, mist filters form no cake and load only to the point where collection equals drainage. As a mist filter loads, the interstitial gas velocity increases, so that efficiency decreases for small droplets that collect by diffusion. Although a third-stage 95 percent DOP filter showed important decreases in efficiency over time for submicron droplets, third-stage HEPA filters operated with efficiencies that consistently approached 100 percent for droplets of all sizes, even after one year of operation. These results suggest that the performance of second-stage filters can be improved if they can be made to drain collected liquid more effectively. For high efficiency, mist collectors should use a HEPA filter as a final stage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALWORKING industries
KW - OIL mist lubrication
KW - Metalworking fluids
KW - MIST COLLECTORS
KW - Oil mist
N1 - Accession Number: 4176653; Boundy, Maryanne 1 Leith, David 1 Hands, David 2 Gressel, Michael 3 Burroughs, G. Edward 3; Affiliation: 1: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 2: Occupational and Environmental Health Sciences, Ford Motor Company, Dearborn, Michigan 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Dec2000, Vol. 15 Issue 12, p928; Subject Term: METALWORKING industries; Subject Term: OIL mist lubrication; Author-Supplied Keyword: Metalworking fluids; Author-Supplied Keyword: MIST COLLECTORS; Author-Supplied Keyword: Oil mist; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/104732200750051166
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lorberau, Charles D.
AU - Pride, J Eannelle L.
T1 - A Laboratory Comparison of Two Media for Use in the Assessment of Dermal Exposure to Pesticides.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2000/12//
VL - 15
IS - 12
M3 - Article
SP - 946
EP - 950
SN - 1047322X
AB - In a laboratory study, gauze pads and Empore1 filters were compared for their ability to assess the dermal exposure of two insecticides (chlorpyrifos and diazinon) and five herbicides (atrazine, alachlor, metolachlor, cyanazine, and 2,4-D ethylhexyl ester). The analytes, when analyzed by gas chromatography with flame ionization detection, were found to have a linear dynamic range to at least 250 Θ g/mL. While a number of different solvents were examined for the desorption of the analytes, methanol was found to be the best solvent for the recovery of all the analytes from 16-ply gauze pads, while 20 percent ethyl acetate in hexane was the preferred solvent for the styrene divinylbenzeneimpregnated Empore filters. Limits of detection (LODs) for the analytes were comparable for both media. For Empore filters, the LODs were 50 Θ g/sample for atrazine, alachlor, chlorpyrifos, diazinon, and 2,4-D ethylhexy ester, with 30 Θ g/ sample for metolachlor, and 80 Θ g/sample for cyanazine. For gauze pads, the LODs were 40 Θ g/sample for metolachlor, 50 Θ g/sample for alachlor, diazinon, and 2,4-D ethylhexy ester, 60 Θ g/sample for atrazine and chlorpyrifos, and 80 Θ g/sample for cyanazine. Both gauze pads and Empore filters gave quantitative recovery for all analytes except chlorpyrifos and 2,4-D ethylhexyl ester under ambient conditions (18[sup o]C, 70% relative humidity) for up to 30 days; these analytes required refrigeration for that period to reach over 90 percent recovery. To assess the effect of environmental conditions on the recovery of the analytes, samples of each media were spiked at about 125 Θ g per analyte/sample (except cyanazine which was spiked at 190 Θ g) and challenged for 8 hr under high (80%) and low (20%) humidity and high (40[sup o]C) and low (5[sup o]C) temperature conditions in an environmental chamber. While the Empore samples gave quantitative recovery after being challenged, recovery from the gauze pads was affected by environmental conditions, especially high temperature. Recovery from gauze pads was below 30 percent for some analytes under high temperature/high humidity conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLORPYRIFOS
KW - DIAZINON
KW - DERMAL SAMPLING
KW - EMPORE
KW - PESTICIDES
N1 - Accession Number: 4176651; Lorberau, Charles D. 1 Pride, J Eannelle L. 2; Affiliation: 1: Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: Project IMHOTEP, Stillman College, Tuscaloosa, Alabama; Source Info: Dec2000, Vol. 15 Issue 12, p946; Subject Term: CHLORPYRIFOS; Subject Term: DIAZINON; Author-Supplied Keyword: DERMAL SAMPLING; Author-Supplied Keyword: EMPORE; Author-Supplied Keyword: PESTICIDES; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/104732200750051184
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - West, Joyce C.
AU - Leaf, Philip J.
AU - Zarin, Deborah A.
T1 - Health Plan Characteristics and Conformance with Key Practice Guideline Psychopharmacologic Treatment Recommendations for Major Depression.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2000/12//
VL - 2
IS - 4
M3 - Article
SP - 223
EP - 237
SN - 15223434
AB - Our objective was to assess whether specific health plan, patient, setting, and psychiatrist characteristics are associated with conformance with key evidence-based practice guideline psychopharmacologic treatment recommendations for major depressive disorder (MDD). Nationally generalizable data from the APA Practice Research Network 1997 Study of Psychiatric Patients and Treatments on 406 adult patients of psychiatrists with MDD were used. This observational study used logistic regression to assess factors associated with guideline conformance. Existing data from a psychiatric practice research network were analyzed. Ninety-one and seven-tenths percent of patients received treatment consistent with the recommendations. Conformance with specific recommendations was as follows: (1) an antidepressant or ECT for moderate, severe, or recurrent depression (92.3%); (2) an antidepressant and an antipsychotic or ECT for psychotic depression (80.9%); (3) an antidepressant and/or psychotherapy for mild depression (97.6%); and (4) no antianxiety medications alone without an antidepressant (96.0%). Variables most strongly associated with nonconformance were (1) lack of psychiatrist financial incentives (OR = 9.6; 95% CI = 1.2, 75.4), (2) psychiatrists with low proportions of public patients (OR = 7.8; 95% CI = 1.9, 32.1), (3) nonmanaged plans (OR = 3.8; 95% CI = 1.4, 10.4), and (4) psychiatrists 62 years or older (OR = 2.9; 95% CI = 1.2, 7.3). Although overall conformance was high, findings have implications for targeting quality improvement initiatives. Research is needed to distinguish clinically appropriate from inappropriate reasons for nonconformance and assess conformance with other recommendations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression -- Treatment
KW - DEPRESSED persons
KW - ANTIDEPRESSANTS
KW - ANTIPSYCHOTIC drugs
KW - PSYCHOTHERAPY patients
KW - SERVICES for
KW - major depression
KW - managed care
KW - practice guidelines
KW - psychopharmacology
KW - quality
N1 - Accession Number: 50189252; West, Joyce C. 1; Email Address: Jwest@psych.org Leaf, Philip J. 2 Zarin, Deborah A. 3; Affiliation: 1: American Psychiatric Practice Research Network, American Psychiatric Institute for Research and Education, 1400 K Street, NW, Washington, DC 20005 2: Department of Mental Hygiene, Johns Hopkins University 3: Technology Assessment Program, Agency for Healthcare Research and Quality; Source Info: Dec2000, Vol. 2 Issue 4, p223; Subject Term: MENTAL depression -- Treatment; Subject Term: DEPRESSED persons; Subject Term: ANTIDEPRESSANTS; Subject Term: ANTIPSYCHOTIC drugs; Subject Term: PSYCHOTHERAPY patients; Subject Term: SERVICES for; Author-Supplied Keyword: major depression; Author-Supplied Keyword: managed care; Author-Supplied Keyword: practice guidelines; Author-Supplied Keyword: psychopharmacology; Author-Supplied Keyword: quality; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 15p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1023/A:1010164520469
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hong, Jin Tae
AU - Park, Kui Lea
AU - Han, Soon Young
AU - Park, Ki Sook
AU - Kim, Hyung Sik
AU - Oh, Se Dong
AU - Lee, Rhee Da
AU - Jang, Seung Jae
T1 - EFFECTS OF OCHRATOXIN A ON CYTOTOXICITY AND CELL DIFFERENTIATION IN CULTURED RAT EMBRYONIC CELLS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2000/12/15/
VL - 61
IS - 7
M3 - Article
SP - 609
EP - 621
SN - 15287394
AB - In the present study, the effects of ochratoxin A (OTA) on cytotoxicity, cell differentiation, and other cell functions in the embryonic midbrain cells, which are dopaminergic, were compared to those in the limb bud cells, which are nondopaminergic, to assess the selectivity of OTA central action. Twelve-day rat embryo midbrain and limb bud cells were cultured in Dulbecco's modified Eagle's medium nutrient and Ham's F12 (1:1) mixture containing 10% Nuserum for 96 h in the presence of various concentrations of OTA. OTA significantly reduced the levels of protein, DNA and glutathione, and [3H]thymidine incorporation into DNA in both embryonic midbrain and limb bud cells in a similar concentration-dependent manner. The IC50 values for cytotoxicity measured by neutral red uptake were 1.10 µ M in the midbrain cells and 1.05 µ M in the limb bud cells. The IC50 values of cell differentiation were 1.10 µ M in the midbrain cells and 1.0 µM in the limb bud cells. The addition of exogenous glutathione (32.5 µ M) did not change the OTA-induced fall in protein and DNA levels, or the IC50 values of cytotoxicity and differentiation in the midbrain and limb bud cells. Data show that OTA does not appear to exert a selective toxic dopaminergic cell action and that OTA-induced cytotoxicity and inhibition of cell differentiation were not prevented by exogenous glutathione. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - OCHRATOXINS
KW - MESENCEPHALON
N1 - Accession Number: 4148648; Hong, Jin Tae 1 Park, Kui Lea 1 Han, Soon Young 1 Park, Ki Sook 1 Kim, Hyung Sik 1 Oh, Se Dong 1 Lee, Rhee Da 1 Jang, Seung Jae 1; Affiliation: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Source Info: 2000, Vol. 61 Issue 7, p609; Subject Term: CELL-mediated cytotoxicity; Subject Term: OCHRATOXINS; Subject Term: MESENCEPHALON; Number of Pages: 13p; Illustrations: 4 Black and White Photographs, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/00984100050194126
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huffman, L. J.
AU - Judy, D. J.
AU - Rao, K. M. K.
AU - Frazer, D. G.
AU - Goldsmith, W. T.
T1 - LUNG RESPONSES TO HYPOTHYROIDISM, HYPERTHYROIDISM, AND LIPOPOLYSACCHARIDE CHALLENGE IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2000/12/15/
VL - 61
IS - 7
M3 - Article
SP - 623
EP - 639
SN - 15287394
AB - The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on some factors involved in lung injury under basal conditions (air exposure) and during an inflammatory response induced by inhalation exposure to lipopolysaccharide (LPS; 100 µg/ml; 3 h) in adult rats. Thyroid status was altered by thyroidectomy or thyroxine injections for 15 d. Hyperthyroidism alone caused a greater degree of lung cell damage, an increase in the permeability of the alveolar–capillary barrier, a rise in the total number of phagocytic cells obtained by bronchoalveolar lavage (BAL), and enhanced nitric oxide (NO) release by phagocytic cells relative to that in euthyroid control animals. Hypothyroidism alone was associated with opposite effects. Exposure of animals to LPS produced inflammatory responses, which included significant increases in lung cell damage, permeability of the alveolar–capillary barrier, number of phagocytic cells obtained by BAL, and NO production by the phagocytic cells. In general, hyperthyroidism enhanced the effects of LPS, while hypothyroidism reduced LPS-induced responses. These results suggest that thyroid status alone can affect some of the factors involved in lung injury and also modulate some of the inflammatory effects of LPS. Hyperthyroidism tends to enhance lung injury, while hypothyroidism seems to reduce lung injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROID diseases
KW - LUNGS -- Physiology
N1 - Accession Number: 4148647; Huffman, L. J. 1 Judy, D. J. 2 Rao, K. M. K. 2 Frazer, D. G. 1 Goldsmith, W. T. 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, and Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2000, Vol. 61 Issue 7, p623; Subject Term: THYROID diseases; Subject Term: LUNGS -- Physiology; Number of Pages: 17p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/00984100050194135
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reasor, Mark J.
AU - Antonini, James M.
T1 - PULMONARY RESPONSES TO SINGLE VERSUS MULTIPLE INTRATRACHEAL INSTILLATIONS OF SILICA IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2000/12/31/
VL - 62
IS - 1
M3 - Article
SP - 9
EP - 21
SN - 15287394
AB - The pulmonary toxicity of particles is often studied using a single intratracheal instillation of the material. It was hypothesized that smaller multiple intratracheal administrations of silica would result in differences in pulmonary responses as compared to a single large intratracheal administration. In the first of a series of experiments, the pulmonary responses in male F344 rats to a single intratracheal instillation of crystalline silica (5 mg/100 g body weight) given on d 0 were compared with those resulting from 5 consecutive daily intratracheal administrations of the dust (1 mg/100 g body weight/d) with the initial dose given on d 0. Controls received saline intratracheally. In the second experiment, the dose was reduced to 1 mg/100 g body weight for the single-dose protocol and 0.2 mg/100 g body weight/d for 5 consecutive days for the multiple-dose protocol. In both experiments, responses were assessed on d 14. In the third experiment, the doses were the same as the first experiment, but the responses were assessed on d 28. The indices of toxicity were cellular differentials recovered by bronchoalveolar lavage, which is an index of inflammation, and the level of albumin in the bronchoalveolar lavage fluid, a measure of damage to the capillary–epithelial barrier. At the higher dose of silica, similar levels of inflammation and lung damage were evident in both dosing protocols. Less severe responses occurred at the lower dose. The comparative pattern between the single and multiple dosing protocols was similar in all three experiments. Since only minor differences were noted in the pulmonary responses when the responses to the single- and multiple-dose protocols were compared, data indicate that the multiple-dose protocol does not offer any advantages over the single-dose protocol. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PULMONARY toxicology
KW - SILICA
KW - RATS as laboratory animals
N1 - Accession Number: 4783522; Reasor, Mark J. 1 Antonini, James M. 2; Affiliation: 1: Department of Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown, West Virginia, USA 2: National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA; Source Info: 2001, Vol. 62 Issue 1, p9; Subject Term: PULMONARY toxicology; Subject Term: SILICA; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/00984100050201631
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fox, Sarah A.
AU - Stein, Judith A.
AU - Sockloskie, Robert J.
AU - Ory, Marcia G.
T1 - Targeted Mailed Materials and the Medicare Beneficiary: Increasing Mammogram Screening Among the Elderly.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/01//
VL - 91
IS - 1
M3 - Article
SP - 55
EP - 61
PB - American Public Health Association
SN - 00900036
AB - Conclusions. A targeted low-cost mailed intervention can help increase screening rates among elderly minority women. The Health Care Financing Administration should promote its benefits aggressively if it expects to reach its target--elderly beneficiaries. (Am J Public Health. 2001;91:55-61) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMOGRAMS
KW - CANCER in women
KW - BREAST cancer
KW - MEDICARE
KW - MEDICAL screening
KW - HEALTH risk assessment
N1 - Accession Number: 3932822; Fox, Sarah A. 1,2; Email Address: sarah_fox@rand.org Stein, Judith A. 3 Sockloskie, Robert J. Ory, Marcia G. 4; Affiliation: 1: RAND, Santa Monica, Calif. 2: Department of Medicine, School of Medicine, University of California, Los Angeles 3: Department of Psychology, University of California, Los Angeles 4: National Institute on Aging, US Department of Health and Human Services, Bethesda, Md.; Source Info: Jan2001, Vol. 91 Issue 1, p55; Subject Term: MAMMOGRAMS; Subject Term: CANCER in women; Subject Term: BREAST cancer; Subject Term: MEDICARE; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pappas, Gregory
AU - Akhtar, Taslim
AU - Gergen, Peter J.
AU - Hadden, Wilbur C.
AU - Khan, Abdul Qayyum
T1 - Health Status of the Pakistani Population: A Health Profile and Comparison With the United States.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/01//
VL - 91
IS - 1
M3 - Article
SP - 93
EP - 98
PB - American Public Health Association
SN - 00900036
AB - Conclusions. There are major inequalities in health within Pakistan and between Pakistan and the United States. Standardized national health examination survey methodology can be used to monitor health status and plan health transition policy in developing countries. (Am J Public Health. 2001 ;91: 93-98) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAKISTANIS
KW - HEALTH
KW - AMERICANS
KW - PUBLIC health
KW - POPULATION
KW - PAKISTAN
KW - UNITED States
N1 - Accession Number: 3933056; Pappas, Gregory 1 Akhtar, Taslim 2 Gergen, Peter J. 3 Hadden, Wilbur C. 4; Email Address: wch2@cdc.gov Khan, Abdul Qayyum 5; Affiliation: 1: Office of the Assistant Secretary for Health, Washington, DC 2: Khyber Medical College, Peshawar, Pakistan 3: Agency for Healthcare Research and Quality, Rockville, Md. 4: National Center for Health Statistics, Centers for Disease Control and Prevention Hyattsville, Md. 5: Pakistan Medical Research Council, Islamabad; Source Info: Jan2001, Vol. 91 Issue 1, p93; Subject Term: PAKISTANIS; Subject Term: HEALTH; Subject Term: AMERICANS; Subject Term: PUBLIC health; Subject Term: POPULATION; Subject Term: PAKISTAN; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - England, Ellen
AU - Key-Schwartz, Rosa
AU - Lesage, Jacques
AU - Carlton, Gary
AU - Streicher, Robert
AU - Song, Ruiguang
T1 - Erratum to "Comparison of Sampling Methods for Monomer and Polyisocyanates of 1,6-Hexamethylene Diisocyanate During Spray Finishing Operations" [Appl Occup Env Hyg 15(6):472-478].
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/01//
VL - 16
IS - 1
M3 - Correction notice
SP - 1
EP - 1
SN - 1047322X
AB - Presents an erratum of the article 'Comparison of Sampling Methods for Monomer and Polyisocyanates of 1,6-Hexamethylene Diisocyanate During Spray Finishing Operations.'
KW - MONOMERS
KW - ANALYTICAL chemistry
N1 - Accession Number: 4230204; England, Ellen 1 Key-Schwartz, Rosa 2 Lesage, Jacques 3 Carlton, Gary 1 Streicher, Robert 2 Song, Ruiguang 2; Affiliation: 1: Institute for Environment, Safety and Occupational Health Risk Analysis, Brooks Air Force Base, Texas 2: Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Institut de Recherche en Santé et en Sécuritédu Travail du Québec (IRSST) Montreal Quebec, Canada; Source Info: Jan2001, Vol. 16 Issue 1, p1; Subject Term: MONOMERS; Subject Term: ANALYTICAL chemistry; Number of Pages: 1p; Illustrations: 1 Chart, 1 Graph; Document Type: Correction notice
L3 - 10.1080/104732201456069
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaowu Pang
AU - Mingjie Zhang
AU - Dayton, Andrew I.
T1 - Development of Dengue virus type 2 replicons capable of prolonged expression in host cells.
JO - BMC Microbiology
JF - BMC Microbiology
Y1 - 2001/01//
VL - 1
M3 - Article
SP - 18
EP - 7
PB - BioMed Central
SN - 14712180
AB - Background: As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated by antibodies to Dengue virus structural proteins, we have begun to investigate the possibility of designing Dengue vaccines based on non-structural proteins. Results: Dengue constructs which lack major structural proteins replicate intracellularly in tissue culture. These replicons are capable of prolonged expression of Dengue virus non-structural proteins for at least seven days in culture. Conclusions: Dengue virus genomes lacking major structural proteins can, like other flaviviruses, replicate intracellularly and express virus non-structural proteins with minimal toxicity to host cells. These findings pave the way for the development of dengue virus replicons as a form of live, attenuated virus vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Microbiology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL vaccines
KW - DENGUE viruses
KW - GENE expression
KW - CHROMOSOME replication
KW - PROTEINS
KW - TISSUE culture
N1 - Accession Number: 29414415; Xiaowu Pang 1; Email Address: dayton@cber.fda.gov Mingjie Zhang 1; Email Address: dayton@cber.fda.gov Dayton, Andrew I. 1,2; Email Address: dayton@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA 2: HFM 315 CBER/FDA, 1401 Rockville Pite, Rockville, MD 20852-1448, USA; Source Info: 2001, Vol. 1, p18; Subject Term: VIRAL vaccines; Subject Term: DENGUE viruses; Subject Term: GENE expression; Subject Term: CHROMOSOME replication; Subject Term: PROTEINS; Subject Term: TISSUE culture; NAICS/Industry Codes: 111421 Nursery and Tree Production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 4 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaowu Pang
AU - Mingjie Zhang
AU - Dayton, Andrew I.
T1 - Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV.
JO - BMC Microbiology
JF - BMC Microbiology
Y1 - 2001/01//
VL - 1
M3 - Article
SP - 28
EP - 9
PB - BioMed Central
SN - 14712180
AB - Background: Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective against dengue virus and HIV, we have attempted to create vectors which express dengue virus non-structural proteins and HIV immunogens. Previously we reported the successful construction of dengue virus replicons which lack structural genes necessary for virion release and spreading infection in culture but which can replicate intracellularly and abundantly produce dengue non-structural proteins. Here we attempted to express heterologous genetic material from these replicons. Results: We cloned into δpre-M/E dengue virus replicon genes for either green fluorescent protein (green fluorescent protein (GFP), HIV gp160 or HIV gp120 and tested the ability of these constructs to express dengue virus proteins as well as the heterologous proteins in tissue culture after transfection of replicon RNA. Conclusions: Heterologous proteins were readily expressed from these constructs. GFP and gp120 demonstrated minimal or no toxicity. Gp160 expressing replicons were found to express proteins abundantly at 36 hours post transfection, but after 50 hrs of transfection, few replicon positive cells could be found despite the presence of cellular debris positive for replicon proteins. This suggested that gp160 expressed from dengue virus replicons is considerably more toxic than either GFP or gp120. The successful expression of heterologous proteins, including HIV gp120 for long periods in culture suggests this vector system may be useful as a vaccine vector, given appropriate delivery methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Microbiology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL genetics
KW - DENGUE viruses
KW - CHROMOSOME replication
KW - HIV (Viruses)
KW - VIRAL vaccines
KW - VIRAL proteins
KW - GREEN fluorescent protein
KW - RNA
N1 - Accession Number: 29414425; Xiaowu Pang 1; Email Address: pang@cber.fda.gov Mingjie Zhang 1; Email Address: zhangm@cber.fda.gov Dayton, Andrew I. 1; Email Address: aidayton@yahoo.com; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Source Info: 2001, Vol. 1, p28; Subject Term: VIRAL genetics; Subject Term: DENGUE viruses; Subject Term: CHROMOSOME replication; Subject Term: HIV (Viruses); Subject Term: VIRAL vaccines; Subject Term: VIRAL proteins; Subject Term: GREEN fluorescent protein; Subject Term: RNA; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 9 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Poirier, Miriam C.
AU - Weston, Ainsely
T1 - Carcinogen Macromolecular Adducts.
JO - Encyclopedic Reference of Cancer
JF - Encyclopedic Reference of Cancer
Y1 - 2001/01//
M3 - Reference Entry
SP - 157
EP - 162
SN - 9783540665274
AB - An encyclopedia entry for "carcinogen-macromolecular adducts" is presented. It is the chemical modifications of nucleic acids and proteins which form in tissues and cells exposed to reactive chemical species. It is characterized by endogenous or exogenous agents. The endogenous formation causes appropriate and inappropriate chemical modification of nucleic acids. Exogenous chemicals include environmental pollutants or drugs that requires activation through metabolism.
KW - CARCINOGENS
KW - CHEMICAL modification of proteins
KW - NUCLEIC acids
KW - DRUG metabolism
KW - MACROMOLECULES
N1 - Accession Number: 23677660; Poirier, Miriam C. 1; Email Address: poirierm@exchange.nih.gov Weston, Ainsely 2; Email Address: agw8@cdc.gov; Affiliation: 1: National Cancer Institute, NIH, Bethesda, MD 2: National Institute of Occupational Safety and Health CDC, Morgantown, WV, USA; Source Info: 2001, p157; Subject Term: CARCINOGENS; Subject Term: CHEMICAL modification of proteins; Subject Term: NUCLEIC acids; Subject Term: DRUG metabolism; Subject Term: MACROMOLECULES; Number of Pages: 6p; Document Type: Reference Entry
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Clarke, Robert W.
T1 - STRAIN-RELATED DIFFERENCES OF NONSPECIFIC RESPIRATORY DEFENSE MECHANISMS IN RATS USING A PULMONARY INFECTIVITY MODEL.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2001/01//
VL - 13
IS - 1
M3 - Article
SP - 85
EP - 102
PB - Taylor & Francis Ltd
SN - 08958378
AB - A number of animal studies have assessed pulmonary host defense mechanisms by inoculating the lungs with the bacterial agent, Listeria monocytogenes. Most studies use only a single strain of the animal to be tested; however, strain-related differences in responsiveness to pulmonary toxicants have been well documented. It was the goal of this current investigation to measure the pulmonary defense responses of two different strains of rats in a lung infectivity model. Fischer 344 (F344) and Sprague-Dawley (SD) rats were instilled intratracheally with 5 × 10[sup 3] or 5 × 10[sup 5] L. monocytogenes, and the effect on mortality, lung injury and inflammation, pulmonary bacterial clearance, and alveolar macrophage (AM) function was determined at 3, 5, and 7 days after bacteria treatment. Pulmonary inoculation with the higher (5 × 10[sup 5] L. monocytogenes ) dose proved to be highly pneumotoxic to the F344 rats as evidenced by an increase in mortality and more severe lung injury and inflammation when compared with the SD rats. After intratracheal instillation with the lower (5 × 10[sup 3] L. monocytogenes ) dose, pulmonary bacterial clearance was slowed and an increase in pulmonary responsiveness was observed for the F344 rats as compared to the SD rats. Specifically, the total number of neutrophils recovered from the lungs and tumor necrosis factor-α secreted by AMs were elevated for the F344 group throughout the 7 days, while cellular chemiluminescence, an index of reactive oxygen species production, and lung albumin and lactate dehydrogenase, indicators of injury, were increased at 3 and 5 days after bacterial instillation. This study demonstrated that respiratory defense function was compromised in F344 rats as evidenced by elevated mortality, slowed pulmonary bacterial clearance, and altered AM function. F344 rats may then represent a sensitive model for the examination of respiratory defense mechanisms after bacterial challenge. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEFENSE reaction (Physiology)
KW - PULMONARY toxicology
N1 - Accession Number: 4050865; Antonini, James M. 1 Roberts, Jenny R. 1 Clarke, Robert W. 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA; Source Info: Jan2001, Vol. 13 Issue 1, p85; Subject Term: DEFENSE reaction (Physiology); Subject Term: PULMONARY toxicology; Number of Pages: 18p; Illustrations: 4 Black and White Photographs, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1080/089583701459083
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schwetz, Bernard A.
T1 - Toxicology at the Food and Drug Administration: New Century, New Challenges.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2001/01//
VL - 20
IS - 1
M3 - Article
SP - 3
EP - 8
PB - Taylor & Francis Ltd
SN - 10915818
AB - Comments on the future needs of expertise within the field of toxicology. Emphasis on environmental and consumer safety issues; Role of toxicology in the development of safety products and wholesome foods; Importance of toxicological data for setting occupational standards.
KW - TOXICOLOGY
KW - COMMERCIAL products -- Testing
KW - ENVIRONMENTAL aspects
N1 - Accession Number: 4318738; Schwetz, Bernard A. 1; Affiliation: 1: Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jan2001, Vol. 20 Issue 1, p3; Subject Term: TOXICOLOGY; Subject Term: COMMERCIAL products -- Testing; Subject Term: ENVIRONMENTAL aspects; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1080/109158101750103297
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Carolis, Gary
T1 - Foreword: Preparing Practitioners for an Evolving System of Care.
JO - Journal of Family Social Work
JF - Journal of Family Social Work
Y1 - 2001/01//
VL - 5
IS - 3
M3 - Article
SP - XVII
SN - 10522158
AB - This paper introduces a series of articles which deals with the potential roles of families in the system of care.
KW - FAMILIES
KW - CARE of people
N1 - Accession Number: 9877312; De Carolis, Gary 1; Affiliation: 1: Chief Child, Adolescent and Family Branch, Federal Center for Mental Health Services, Substance Abuse & Mental Health Services Administration; Source Info: 2001, Vol. 5 Issue 3, preceding pXVII; Subject Term: FAMILIES; Subject Term: CARE of people; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Encinosa, William
T1 - The economics of regulatory mandates on the HMO market.
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2001/01//
VL - 20
IS - 1
M3 - Article
SP - 85
EP - 107
SN - 01676296
AB - Recently proposed HMO regulations have involved mandates of two forms: (1) minimum quality standards, and (2) mandated increases in access to speciality care. I show that piecemeal regulation, which uses only one of either mandate (1) or (2), may decrease welfare for all HMO consumers. Under full regulation using both (1) and (2), if the minimum standard is set too low, say, due to political bargaining, a floor-to-ceiling effect occurs. This involves HMOs setting quality at the minimum standard, even when their quality would be above the standard in an unregulated market. Finally, I show how premiums may either increase or decrease under a mandate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH maintenance organizations
KW - MANDATES (Territories)
KW - QUALITY standards
KW - CONSUMERS
KW - MARKETS
KW - MEDICAL care
KW - Adverse selection
KW - Health insurance regulation
KW - Minimum standards
N1 - Accession Number: 11943617; Encinosa, William 1; Email Address: wencinos@ahrq.gov; Affiliation: 1: Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Suite 605, 2101 E Jefferson Street, Rockville, MD 20852, USA.; Source Info: Jan2001, Vol. 20 Issue 1, p85; Subject Term: HEALTH maintenance organizations; Subject Term: MANDATES (Territories); Subject Term: QUALITY standards; Subject Term: CONSUMERS; Subject Term: MARKETS; Subject Term: MEDICAL care; Author-Supplied Keyword: Adverse selection; Author-Supplied Keyword: Health insurance regulation; Author-Supplied Keyword: Minimum standards; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parascandola, John L.
AU - Parascandola, J L
T1 - Alice Catherine Evans (1881-1975).
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 2001/01//
VL - 22
IS - 1
M3 - journal article
SP - 105
EP - 111
SN - 01975897
AB - Presents an obituary for Alice Catherine Evans, microbiologist who played a crucial role in the recognition of the disease brucellosis.
KW - MICROBIOLOGY -- History
KW - ANIMALS
KW - BRUCELLOSIS
KW - HISTORY
KW - UNITED States
KW - EVANS, Alice Catherine, 1881-1975
N1 - Accession Number: 9167335; Parascandola, John L. 1 Parascandola, J L 2; Affiliation: 1: Public Health Service Historian, U.S. Public Health Service, 5600 Fishers Lane, Room 18-23, Rockville, Maryland 20857 2: U.S. Public Health Service, 5600 Fishers Lane, Room 18-23, Rockville, Maryland 20857, USA; Source Info: 2001, Vol. 22 Issue 1, p105; Subject Term: MICROBIOLOGY -- History; Subject Term: ANIMALS; Subject Term: BRUCELLOSIS; Subject Term: HISTORY; Subject Term: UNITED States; People: EVANS, Alice Catherine, 1881-1975; Number of Pages: 7p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burke, Laurie B.
T1 - US Regulation of Pharmaceutical Outcomes Research.
JO - Value in Health
JF - Value in Health
Y1 - 2001/01//Jan/Feb2001
VL - 4
IS - 1
M3 - Article
SP - 5
EP - 7
PB - Elsevier Science
SN - 15244733
AB - Points out that the United States Food and Drug Administration (FDA) must often determine when information provided by outcomes research is adequate to support labeling and advertising claims. Lack of clarity in terminology used; Overlapping of categories of what appears to fall under the umbrella of outcomes research; Policy development for outcomess evidentiary requirements.
KW - OUTCOME assessment (Medical care)
KW - PHARMACEUTICAL policy
KW - UNITED States
KW - FDA
KW - outcomes research
KW - pharmaceuticals
KW - regulation
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 6119377; Burke, Laurie B. 1; Affiliation: 1: Chief, Evidence Review Branch, Division of Drug Marketing, Advertising and Communications (DDMAC), Food and Drug Administration (FDA); Source Info: Jan/Feb2001, Vol. 4 Issue 1, p5; Subject Term: OUTCOME assessment (Medical care); Subject Term: PHARMACEUTICAL policy; Subject Term: UNITED States; Author-Supplied Keyword: FDA; Author-Supplied Keyword: outcomes research; Author-Supplied Keyword: pharmaceuticals; Author-Supplied Keyword: regulation; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1524-4733.2001.004001005.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weindruch, Richard
AU - Keenan, Kevin P.
AU - Carney, John M.
AU - Fernandes, Gabriel
AU - Feuers, Ritchie J.
AU - Floyd, Robert A.
AU - Halter, Jeffrey B.
AU - Ramsey, Jon J.
AU - Richardson, Arlan
AU - Roth, George S.
AU - Spindler, Stephen R.
T1 - Caloric Restriction Mimetics.
JO - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Y1 - 2001/01/02/
VL - 56
IS - suppl_1
M3 - Article
SP - 20
EP - 33
SN - 10795006
AB - Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being tested in nonhuman primates. One way to apply these findings to human health is to identify and test agents that may mimic critical actions of CR. Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics exist. It was recommended that studies on oxidative stress should emphasize mitochondrial function and to test the efficacy of nitrone and other antioxidants in mimicking CR's effects. Studies should also focus on the long-term effects of compounds known to lower circulating glucose and insulin concentrations or to increase insulin sensitivity. Also, four other developing areas were identified: intermediary metabolism, response to infection, stress responses, and source of dietary fat. These areas are important because either they hold promise for the discovery of new mimetics or they need to be explored prior to initiation of CR trials in humans. Other recommendations were that transgenic approaches and adult-onset CR should be emphasized in future studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journals of Gerontology Series A: Biological Sciences & Medical Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - RODENTS as laboratory animals
KW - GLUCOSE -- Physiological effect
KW - OXIDATIVE stress
KW - INSULIN resistance
N1 - Accession Number: 80090448; Weindruch, Richard 1,2,3,4,5,6,7,8,9,10,11 Keenan, Kevin P. 1,2,3,4,5,6,7,8,9,10,11 Carney, John M. 1,2,3,4,5,6,7,8,9,10,11 Fernandes, Gabriel 1,2,3,4,5,6,7,8,9,10,11 Feuers, Ritchie J. 1,2,3,4,5,6,7,8,9,10,11 Floyd, Robert A. 1,2,3,4,5,6,7,8,9,10,11 Halter, Jeffrey B. 1,2,3,4,5,6,7,8,9,10,11 Ramsey, Jon J. 1,2,3,4,5,6,7,8,9,10,11 Richardson, Arlan 1,2,3,4,5,6,7,8,9,10,11 Roth, George S. 1,2,3,4,5,6,7,8,9,10,11 Spindler, Stephen R. 1,2,3,4,5,6,7,8,9,10,11; Affiliation: 1: Department of Medicine, University of Wisconsin, Madison 2: Merck Research Laboratories, West Point, Pennsylvania 3: Centaur Pharmaceuticals, Inc., Sunnyvale, California 4: Department of Medicine, University of Texas Health Science Center, San Antonio 5: National Center for Toxicological Research, Jefferson, Arkansas 6: Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 7: The Geriatrics Center, University of Michigan, Ann Arbor 8: Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 9: Department of Physiology, University of Texas Health Science Center, San Antonio 10: Molecular Physiology and Genetics Section, Gerontology Research Center, Baltimore, Maryland 11: Department of Biochemistry, University of California, Riverside; Source Info: 2001, Vol. 56 Issue suppl_1, p20; Subject Term: LOW-calorie diet; Subject Term: RODENTS as laboratory animals; Subject Term: GLUCOSE -- Physiological effect; Subject Term: OXIDATIVE stress; Subject Term: INSULIN resistance; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Poehlman, Eric T.
AU - Turturro, Angelo
AU - Bodkin, Noni
AU - Cefalu, William
AU - Heymsfield, Steve
AU - Holloszy, John
AU - Kemnitz, Joseph
T1 - Caloric Restriction Mimetics.
JO - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Y1 - 2001/01/02/
VL - 56
IS - suppl_1
M3 - Article
SP - 45
EP - 54
SN - 10795006
AB - As the only paradigm that has consistently increased life span and inhibited the onset and/or progression of disease, dietary restriction has multiple effects on a variety of organ systems. In this brief review, the goal of the panel was to attempt to understand the role of changes in physical activity and body composition as possible modulators of the life span in experimental animals and humans. We focus on whether changes in exercise behavior and body composition produce similar changes as those found in dietary restriction and whether these changes can be used to either replace or enhance the beneficial effects of dietary restriction. The complexity of the two stimuli is emphasized in our report, with suggestions offered on how to better interpret existing research. Our panel briefly examines evidence in experimental animals and humans about the specific contributions of each of these factors to altering life span and age-related pathologies. We also discuss additional animal studies and/or human intervention studies that could be performed to clarify these issues. Finally, we provide suggested avenues for future research in this area of changes in physical activity and body composition as dietary restriction mimetics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journals of Gerontology Series A: Biological Sciences & Medical Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - LIFE spans (Biology)
KW - DISEASE progression
KW - HUMAN body composition
KW - PATHOLOGY
KW - PHYSIOLOGICAL aspects
N1 - Accession Number: 80090450; Poehlman, Eric T. 1,2,3,4,5,6 Turturro, Angelo 1,2,3,4,5,6 Bodkin, Noni 1,2,3,4,5,6 Cefalu, William 1,2,3,4,5,6 Heymsfield, Steve 1,2,3,4,5,6 Holloszy, John 1,2,3,4,5,6 Kemnitz, Joseph 1,2,3,4,5,6; Affiliation: 1: Department of Medicine, University of Vermont, Burlington 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 3: Obesity and Diabetes Research Center, Department of Physiology, University of Maryland, Baltimore 4: St. Luke's–Roosevelt Hospital and Columbia University College of Physicians and Surgeons, New York City 5: Division of Geriatrics and Gerontology, Section of Applied Physiology, Washington University School of Medicine, St. Louis, Missouri 6: Department of Physiology and Wisconsin Regional Primate Research Center, University of Wisconsin, Madison; Source Info: 2001, Vol. 56 Issue suppl_1, p45; Subject Term: LOW-calorie diet; Subject Term: LIFE spans (Biology); Subject Term: DISEASE progression; Subject Term: HUMAN body composition; Subject Term: PATHOLOGY; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mcclain, R. Michael
AU - Keller, Douglas
AU - Casciano, Dan
AU - Fu, Peter
AU - Macdonald, James
AU - Popp, James
AU - Sagartz, John
T1 - Neonatal Mouse Model: Review of Methods and Results.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2001/01/02/Jan2001 Supplement
VL - 29
IS - 1S
M3 - Article
SP - 128
EP - 137
PB - Sage Publications Inc.
SN - 01926233
AB - The neonatal mouse model, in various forms, has been used experimentally since 1959 and a large number of chemicals have been tested. The neonatal model is known to be very sensitive for the detection of carcinogens that operate via a genotoxic mode of action. In contrast, it is known not to respond to chemicals that act via epigenetic mechanisms, commonly observed in the two-year carcinogenicity studies. As such, the model has a high sensitivity and specifi city in its response. Dose selection for the neonatal model is based on the maximum tolerated or feasible dose. Traditionally, compounds have been tested via the IP route of administration in this model. In some cases, this has limited the amount of material that can be administered because of the low dosing volumes (10 to 20 μL) that can be administered IP. For the ILSI project, the neonatal model was adapted for oral administration, which has the advantages of being the same route for which most pharmaceuticals are administered. In addition, a 10-fold increase in the volume of administration (100 to 200 μL) and the ability to dose drugs in suspension, permits much higher doses to be used as compared to the IP route of administration. The spontaneous tumors in the neonatal model occurred mainly in the liver of male mice and lung of male and female mice with a few tumors observed in the Harderian gland. The positive control, DEN produced a robust, uniform, and reproducible tumor response with the target organs essentially limited to liver and lung. A total of 13 compounds out of the 21 ILSI ACT compounds were evaluated in the neonatal model involving 18 studies with duplicate studies for some compounds. The genotoxic carcinogens including those used as positive controls were clearly positive (cyclophosphamide, diethylnitrosamine, 6-nitrochrysene). The non-genotoxicrodent carcinogens were clearly negative (chlorpromazine, sulfi soxazole, sulfamethoxazole, clofi brate, DEHP, haloperidol, metaproteranol, and phenobarbital). The non-genotoxic human carcinogen (cyclosporin) was clearly negative. The two other human carcinogens phenacetin and DES were negative and interestingly estradiol was negative in one of the two oral studies, but was clearly positive in the other. Considering the mode of action for three of the human carcinogens (DES, cyclosporin and phenacetin), which were negative in this model, the mode of action in humans is likely to be epigenetic. Overall, for the 3 clearly genotoxic chemicals, all were positive. For the 9 clearly non-genotoxic chemicals, all 9 were negative. The two human carcinogens for which genotoxicity may or may not play a role (DES and phenacetin) were negative and estradiol was positive in 1 of the two oral studies. Overall, the extensive database for compounds tested in the neonatal mouse model would support its use as an alternative model for the assessment of the carcinogenic potential of a chemical. The model responds to chemicals that act via a genotoxic mode of action that represent a greater concern for human cancer risk. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - 52-weeks
KW - alternatives
KW - bioassay
KW - carcinogenicity
KW - Neonatal mouse
KW - short-term
KW - testing
N1 - Accession Number: 54381053; Mcclain, R. Michael 1 Keller, Douglas 2 Casciano, Dan 2 Fu, Peter 2 Macdonald, James 2 Popp, James 2 Sagartz, John 2; Affiliation: 1: National Center for Toxicological Research, Food and Drug Administration, Sanofi-Synthelabo Research, Schering-Plough Research Institute, DuPont Pharmaceuticals Company, Monsanto Life Sciences, michaelmcclain@msn.com 2: National Center for Toxicological Research, Food and Drug Administration, Sanofi-Synthelabo Research, Schering-Plough Research Institute, DuPont Pharmaceuticals Company, Monsanto Life Sciences; Source Info: Jan2001 Supplement, Vol. 29 Issue 1S, p128; Author-Supplied Keyword: 52-weeks; Author-Supplied Keyword: alternatives; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: Neonatal mouse; Author-Supplied Keyword: short-term; Author-Supplied Keyword: testing; Number of Pages: 10p; Document Type: Article; Full Text Word Count: 6732
L3 - 10.1080/019262301753178537
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - London, A. S.
AU - Fleishman, J. A.
AU - Goldman, D. P.
AU - McCaffrey, D. F.
AU - Bozzette, S. A.
AU - Shapiro, M. F.
AU - Leibowitz, A. A.
T1 - Use of unpaid and paid home care services among people with HIV infection in the USA.
JO - AIDS Care
JF - AIDS Care
Y1 - 2001/02//
VL - 13
IS - 1
M3 - Article
SP - 99
EP - 121
PB - Routledge
SN - 09540121
AB - This paper examines utilization of paid and unpaid home health care using data from a nationally representative sample of HIV-positive persons receiving medical care in early 1996 (N = 2,864). Overall, 21.0% used any home care, 12.2% used paid care and 13.6% used unpaid care. Most (70.0%) users of home care received care from only one type of provider. Substantially more hours of unpaid than paid care were used. We also found evidence of a strong association between type of service used and type of care provider: 62.4% of persons who used nursing services only received paid care only; conversely, 55.5% of persons who used personal care services only received care only from unpaid caregivers. Use of home care overall was concentrated among persons with AIDS: 39.5% of persons with AIDS received any home health care, compared to 9.5% of those at earlier disease stages. In addition to having an AIDS diagnosis, logistic regression analyses indicated that other need variables significantly increased utilization; a higher number of HIV-related symptoms, lower physical functioning, less energy, a diagnosis of CMV and a recent hospitalization each independently increased the odds of overall home care utilization. Sociodemographic variables had generally weak relationships with overall home care utilization. Among users of home care, non-need variables had more influence on use of paid than unpaid care. Both paid and unpaid home health care is a key component of community-based systems of care for people with HIV infection. The results presented in this paper are the first nationally representative estimates of home care utilization by persons with HIV/AIDS and are discussed with reference to policy and future research. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - MEDICAL care -- United States
KW - HOME care services
KW - UNITED States
N1 - Accession Number: 3998534; London, A. S. 1 Fleishman, J. A. 2 Goldman, D. P. 3 McCaffrey, D. F. 3 Bozzette, S. A. 4 Shapiro, M. F. 5 Leibowitz, A. A. 6; Affiliation: 1: Department of Sociology, Kent State University 2: Agency for Healthcare Research and Quality 3: RAND 4: University of California, San Diego and RAND 5: University of California, Los Angeles School of Medicine and RAND 6: University of California, Los Angeles and RAND, USA; Source Info: Feb2001, Vol. 13 Issue 1, p99; Subject Term: HIV-positive persons; Subject Term: MEDICAL care -- United States; Subject Term: HOME care services; Subject Term: UNITED States; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621610 Home Health Care Services; Number of Pages: 23p; Illustrations: 8 Charts; Document Type: Article; Full Text Word Count: 12724
L3 - 10.1080/09540120020018215
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Satcher, David
T1 - Why We Need an International Agreement on Tobacco Control.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/02//
VL - 91
IS - 2
M3 - Editorial
SP - 191
EP - 193
PB - American Public Health Association
SN - 00900036
AB - This article addresses the need for an international agreement on tobacco control. The percentage of deaths worldwide that is attributable to tobacco use is projected to increase from 6 percent in 1990 to 12.3 percent in 2020. Cigarette smuggling provides consumers with products at below-market prices, making the action a public health problem as well as a law enforcement problem. Tobacco manufacturers adapt their advertising practices for developing countries, often across borders. Data and data analysis are important tools in communicating the nature and scope of the tobacco problem to policymakers and the public and in monitoring progress in controlling use of tobacco.
KW - TOBACCO -- Law & legislation
KW - TREATIES
KW - MORTALITY -- Statistics
KW - SMUGGLING
KW - PUBLIC health
KW - LAW enforcement
KW - ADVERTISING -- Tobacco
KW - DEVELOPING countries
N1 - Accession Number: 4034923; Satcher, David 1; Affiliation: 1: Surgeon General and Assistant Secretary for Health, US Public Health Service, US Department of Health and Human Services; Source Info: Feb2001, Vol. 91 Issue 2, p191; Subject Term: TOBACCO -- Law & legislation; Subject Term: TREATIES; Subject Term: MORTALITY -- Statistics; Subject Term: SMUGGLING; Subject Term: PUBLIC health; Subject Term: LAW enforcement; Subject Term: ADVERTISING -- Tobacco; Subject Term: DEVELOPING countries; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Rust, George
AU - Curtin, Thomas
AU - Gaston, Marilyn Hughes
AU - Vinicor, Frank
AU - Chin, Marshall H.
AU - Auerbach, Steven B.
AU - Cook, Sandy
AU - Harrison, James
AU - Koppert, Julie
AU - Lei Jin
AU - Thiel, Fay
AU - Karrison, Theodore G.
AU - Harrand, Anita
AU - Schaefer, Cynthia T.
AU - Takashima, Herbert T.
AU - Egbert, Nancy
AU - Sin-Ching Chiu
AU - McNabb, Wylie
T1 - Letters to the Editor.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/02//
VL - 91
IS - 2
M3 - Letter
SP - 318
EP - 320
PB - American Public Health Association
SN - 00900036
AB - Two letters to the editor are presented in response to the article "Quality of Diabetes Care in Community Health Centers," by M. H. Chin and others in the 2000 issue.
KW - LETTERS to the editor
KW - DIABETES
KW - MEDICAL care -- Quality control
KW - COMMUNITY health services
KW - PUBLIC health
N1 - Accession Number: 4035102; Rust, George 1; Email Address: rustg@msm.edu Curtin, Thomas 2 Gaston, Marilyn Hughes 3; Email Address: mgastom@hrsa.gov Vinicor, Frank 4 Chin, Marshall H. 5,6; Email Address: mchin@medicine.bsd.uchicago.edu Auerbach, Steven B. 7 Cook, Sandy 5,6 Harrison, James 8 Koppert, Julie 9 Lei Jin 5,6 Thiel, Fay 10 Karrison, Theodore G. 5,6 Harrand, Anita 11 Schaefer, Cynthia T. 12 Takashima, Herbert T. 13 Egbert, Nancy 14 Sin-Ching Chiu 15 McNabb, Wylie 5,6; Affiliation: 1: National Center for Primary Care, Morehouse School of Medicine, Atlanta, Ga. 2: National Association of Community Health Centers, Washington, DC 3: Bureau of Primary Health Care, Health Resources and Services Administration, Bethesda, Md. 4: Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Ga. 5: Department of Medicine, Diabetes Research and Training Center, University of Chicago, Chicago, Ill. 6: Department of Health Studies, Diabetes Research and Training Center, University of Chicago, Chicago, Ill. 7: Health Resources and Services Administration, New York, NY 8: North Woods Community Health Center, Minong, Wis. 9: MidWest Clinicians' Network, Inc., Kenton, Ohio 10: MidWest Clinicians' Network, Inc., Okomos, Mich. 11: Hamilton Family Medical Center, Flint, Mich. 12: ECHO Health Center, Louisville, Ind. 13: Health Resources and Services Administration, Kansas City, Mo. 14: Health Resources and Services Administration, Chicago, Ill. 15: Family Medical Center, Temperance, Mich.; Source Info: Feb2001, Vol. 91 Issue 2, p318; Subject Term: LETTERS to the editor; Subject Term: DIABETES; Subject Term: MEDICAL care -- Quality control; Subject Term: COMMUNITY health services; Subject Term: PUBLIC health; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boiano, James M.
AU - Hull, R. Delon
T1 - Development of a National Occupational Exposure Survey and Database Associated with NIOSH Hazard Surveillance Initiatives.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 128
EP - 134
SN - 1047322X
AB - NIOSH pioneered hazard surveillance in the workplace by designing and conducting the 1972 to 1974 National Occupational Hazard Survey (NOHS), the 1981 to 1983 National Occupational Exposure Survey (NOES), and the 1984 to 1989 National Occupational Health Survey of Mining (NOHSM). The databases developed from these three on-site surveys represent unique resources for associating potential chemical, physical and biological agents with industries and occupational groups. The data have been a primary source of information for NIOSH, regulatory agencies, health professionals, researchers, and labor organizations in establishing priorities for prevention strategies that include medical and engineering interventions, development of occupational standards, and the identification of research needs. Recognizing that the data from these surveys are becoming dated, a multidisciplinary team comprising members from various NIOSH research divisions was established to develop a hazard surveillance strategy for the Institute, including options for a national hazard surveillance survey and database. The proposed new hazard survey builds on lessons learned from the previous surveys, seeks opportunities to incorporate existing data from other sources, expands the scope of industries and hazards, and takes advantage of advances in data gathering, processing and dissemination technology. This article presents current considerations and recommendations for a new hazard survey and database. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - INDUSTRIAL hygiene
KW - EXPOSURE DATABASES
KW - OCCUPATIONAL HAZARD SURVEILLANCE
N1 - Accession Number: 4230191; Boiano, James M. 1 Hull, R. Delon 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Feb2001, Vol. 16 Issue 2, p128; Subject Term: DATABASES; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: EXPOSURE DATABASES; Author-Supplied Keyword: OCCUPATIONAL HAZARD SURVEILLANCE; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/104732201460217
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hewett, Paul
T1 - Misinterpretation and Misuse of Exposure Limits.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 251
EP - 256
SN - 1047322X
AB - Users of occupational exposure limits (OELs) often fail to distinguish between the complementary processes of risk assessment and exposure (risk) management. The former refers to those activities that lead to the selection of a reasonably protective exposure limit and often includes an analysis of exposure databases and an evaluation of group-based risk. The latter focuses on individual risk, and refers to those actions required of employers to ensure that each employee is unlikely to incur harm to health. This presentation focuses on how this failure to distinguish leads to misinterpretation and misuse of OELs. A typical OEL definition consists of at least three components: a concentration, an averaging time, and a target (usually the individual worker). OELs are occasionally improperly applied, resulting in a reduction of the expected level of protection. For example, sampling strategies proposed by the American Industrial Hygiene Association (AIHA) and Comité Européen de Normalisation (CEN) permit workers to be aggregated into exposure groups. Under certain circumstances this practice can leave some workers unevaluated and unprotected. Protection is also reduced when the averaging time is extended from a single shift to multiple shifts. Frequently, OELs are misinterpreted as upper limits to exposures averaged over weeks, months, or even years, rather than a single shift. Much of this confusion can be traced to the desire of some to reconcile research (epidemiology) sampling strategies with compliance sampling strategies. But the two have fundamentally different goals and objectives. Others are simply attracted to alternative OEL interpretations that permit frequent overexposures (i.e., measurements that exceed the OEL), thus making compliance easier. Given the current limitations of industrial hygiene and occupational epidemiology, and the general unwillingness of employers to routinely collect exposure data, OELs should continue to be defined as upper limits for single shift exposures. The current OEL model, which permits the use of proximate risk management goals to realize long-range objectives, should be retained. There are, however, valid reasons for augmenting this model to include criteria for evaluating compliance with long-range objectives. The augmented OEL model would be applicable to future new and revised OELs. The author suggests that OEL setting organizations consider harmonizing definitions and statistical interpretations for bothexisting and new OELs, thus minimizing future misinterpretation and misuse. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THRESHOLD limit values (Industrial toxicology)
KW - INDUSTRIAL hygiene
KW - EPIDEMIOLOGY
N1 - Accession Number: 4230169; Hewett, Paul 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Feb2001, Vol. 16 Issue 2, p251; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: INDUSTRIAL hygiene; Subject Term: EPIDEMIOLOGY; Number of Pages: 6p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1080/104732201460415
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Risi, Dave
AU - Dobbin, Denny
AU - Zaebst, Dennis
AU - Tischer, Martin
T1 - Workshop on Harmonization of Serving Multiple Needs with Occupational Exposure Databases, Session II.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 304
EP - 308
SN - 1047322X
AB - Highlights the workshop, 'Harmonization of Serving Multiple Needs with Occupational Exposure Databases (Session II)' in London, England. Goal of the workshop to determine users and the use of occupational exposure database; Identification of key parameters for exposure databases; List of guide areas identified by the workshop.
KW - DATABASES
KW - INDUSTRIAL toxicology
KW - CONGRESSES
KW - ENGLAND
KW - LONDON (England)
N1 - Accession Number: 4230160; Risi, Dave 1 Dobbin, Denny 2 Zaebst, Dennis 3 Tischer, Martin 4; Affiliation: 1: Atrion International, Inc., Reston, Virginia 2: ACGIH Computer Committee, Chapel Hill, North Carolina 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio 4: Federal Institute of Occupational Safety and Health, Dortmund, Germany; Source Info: Feb2001, Vol. 16 Issue 2, p304; Subject Term: DATABASES; Subject Term: INDUSTRIAL toxicology; Subject Term: CONGRESSES; Subject Term: ENGLAND; Subject Term: LONDON (England); Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/104732201460505
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tickner, John
AU - Armstrong, Thomas W.
AU - Bloom, Thomas F.
T1 - Workshop on Harmonization of Serving Future Needs with Occupational Exposure Databases—Inhalation Modeling, Session IIIA.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 309
EP - 314
SN - 1047322X
AB - This workshop was one of several that took place at the International Symposium on Occupational Exposure Databases and Their Application for the Next Millennium held in London from November 1–3, 1999. About 30 delegates participated in the workshop. The agenda for the discussions was provided by a white paper prepared by the organizers. The workshop produced a conceptual outline for a general-purpose prediction model for inhalation exposure, and constructed a list of important input variables for successful model development. Evaluation of prototype models was discussed in some detail, and the workshop concluded with suggestions for taking forward the ideas discussed and maintaining the momentum and interest generated during the symposium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - INDUSTRIAL toxicology
KW - CONGRESSES
KW - ENGLAND
KW - LONDON (England)
N1 - Accession Number: 4230158; Tickner, John 1 Armstrong, Thomas W. 2 Bloom, Thomas F. 3; Affiliation: 1: Health and Safety Executive, United Kingdom 2: ExxonMobil Biomedical Sciences, Inc 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Feb2001, Vol. 16 Issue 2, p309; Subject Term: DATABASES; Subject Term: INDUSTRIAL toxicology; Subject Term: CONGRESSES; Subject Term: ENGLAND; Subject Term: LONDON (England); Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/104732201460514
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abell, Martin T.
AU - Woebkenberg, Mary Lynn
AU - Armstrong, Thomas W.
AU - Stenzel, Mark
T1 - Research Recommendations of the NORA Exposure Assessment Methods Team.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/02//
VL - 16
IS - 2
M3 - Article
SP - 331
EP - 333
SN - 1047322X
AB - Focuses on research recommendations of the National Occupational Research Agenda, a framework to guide occupational safety by the exposure assessment methods (EAM) team in the United States. Aims of the EAM team; Concept of exposure assessment.
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - UNITED States
N1 - Accession Number: 4230153; Abell, Martin T. 1 Woebkenberg, Mary Lynn 1 Armstrong, Thomas W. 2 Stenzel, Mark 3; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 3: Occidental Chemical Corporation, Dallas, Texas; Source Info: Feb2001, Vol. 16 Issue 2, p331; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/104732201460569
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Türesin, F.
AU - Gürsel, İ.
AU - Hasirci, V.
T1 - Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release.
JO - Journal of Biomaterials Science -- Polymer Edition
JF - Journal of Biomaterials Science -- Polymer Edition
Y1 - 2001/02//
VL - 12
IS - 2
M3 - Article
SP - 195
EP - 207
PB - Taylor & Francis Ltd
SN - 09205063
AB - Various random copolyesters of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV) and 3-hydroxybutyrate and 4-hydroxybutyrate P(3HB-4HB) were used in the construction of biodegradable, implantable rods for the local delivery of antibiotics (Sulperazone[sup ®] and Duocid[sup ®]) in chronic osteomyelitis therapy. Drug loading, type of active agent, and additional coating of the implant surface all have significant contributions to the in vitro release profile. The rate and duration of Sulperazone[sup ®] release from P(3HB-4HB) rods were controlled by the polymer/drug ratio (drug loading). The rate of drug dissolution was substantially higher than that of polymer degradation. Therefore, the release phenomenon was more dependent on drug dissolution rather than on polymer degradation or diffusion. Coating rods with the same type of polymer substantially reduced the initial burst effect observed with the uncoated rods, and significantly decreased the release rate so that the release kinetics became almost zero order. Antibiotic release from coated rods was sustained for over a period of 2 weeks at a constant rate, whereas uncoated rods released their contents in less than a week. Impregnation of Duocid[sup ®] into the hydrophobic polymer matrix yielded a rod with a smoother surface topography. The release from these rods was significantly higher than for rods loaded with Sulperazone[sup ®] and a zero order release could not be obtained with these samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERS
KW - ORTHOPEDIC implants
KW - OSTEOMYELITIS -- Treatment
KW - ANTIBIOTICS
KW - BIODEGRADABLE IMPLANTS
KW - Controlled drug delivery
KW - Osteomyelitis
KW - POLYHYDROXYALKANOATES
N1 - Accession Number: 5254423; Türesin, F. 1 Gürsel, İ. 2 Hasirci, V. 3; Affiliation: 1: Health Sciences Centre, Gastrointestinal Sciences, 3330 Hospital Drive NW,Calgary T2N 4N1, AB Cananda 2: Center for Biologics Research, Food and Drug Administration, Laboratory of Retroviral Immunology, Building 29 A, Rm. 3D22, 8800 Rockville Pike, NIH Campus, Bethesda, MD 20892, USA 3: Middle East Technical University, Department of Biologicial Sciences, Biotechnology Research Unit, 06531 Ankara, Turkey; Source Info: Feb2001, Vol. 12 Issue 2, p195; Subject Term: POLYMERS; Subject Term: ORTHOPEDIC implants; Subject Term: OSTEOMYELITIS -- Treatment; Subject Term: ANTIBIOTICS; Author-Supplied Keyword: BIODEGRADABLE IMPLANTS; Author-Supplied Keyword: Controlled drug delivery; Author-Supplied Keyword: Osteomyelitis; Author-Supplied Keyword: POLYHYDROXYALKANOATES; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1163/156856201750180924
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weir, Jerry P.
T1 - Infection of human NT2 cells and differentiated NT-neurons with herpes simplex virus and replication-incompetent herpes simplex virus vectors.
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
Y1 - 2001/02//
VL - 7
IS - 1
M3 - Article
SP - 43
EP - 51
SN - 13550284
AB - The human embryonal carcinoma cell line NT2 differentiates irreversibly into postmitotic neuron-like cells following treatment with retinoic acid. These differentiated NT-neurons resemble central nervous system (CNS) neurons and are characterized by development of dendrites and axons and the expression of neuron-specific markers. Because of their unique biological characteristics, NT-neurons were investigated for their utility as a system for studying the replication of herpes simplex virus (HSV) in the neuron and for evaluating characteristics of HSV vectors designed for gene delivery to the neuron. Virus replication in differentiated NT-neurons was significantly reduced and delayed relative to replication in undifferentiated NT2 cells. Replication of thymidinekinase (tk) deficient HSV was further impaired in NT-neurons, reflecting the behavior of tk-negative virus in primary neurons in vitro and ganglia in vivo . Furthermore, replication-incompetent HSV vectors were capable of infecting NT-neurons, expressing a foreign gene, and persisting in a recoverable state for at least 2 weeks following delivery. These results suggest that differentiated NT-neurons can provide a continuous source of human, post-mitotic neurons-like cells for the study of HSV biology and HSV vector development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of NeuroVirology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMBRYONIC stem cells
KW - NEURONS
KW - HERPES simplex virus
KW - GENETIC vectors
KW - VIRAL replication
KW - GENE expression
KW - HERPES SIMPLEX VIRUS CELL MUTANTS HERPES SIMPLEX VIRUS VECTORS CULTURE MODEL THYMIDINE-KINASE
N1 - Accession Number: 12545731; Weir, Jerry P. 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Feb2001, Vol. 7 Issue 1, p43; Subject Term: EMBRYONIC stem cells; Subject Term: NEURONS; Subject Term: HERPES simplex virus; Subject Term: GENETIC vectors; Subject Term: VIRAL replication; Subject Term: GENE expression; Author-Supplied Keyword: HERPES SIMPLEX VIRUS CELL MUTANTS HERPES SIMPLEX VIRUS VECTORS CULTURE MODEL THYMIDINE-KINASE; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, John F.
AU - Gough, Bobby J.
AU - Suber, Robert L.
AU - Gaylor, David W.
T1 - CORRELATION OF BLOOD CHOLINESTERASE LEVELS WITH TOXICITY OF SARIN IN RATS.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2001/02/09/
VL - 62
IS - 3
M3 - Article
SP - 161
EP - 174
SN - 15287394
AB - The dose-mortality response curve for sarin when administered to pregnant rats is extremely steep. The pregnant animal either died during the treatment or survived with no observable fetal toxicity. Animals that died displayed many symptoms characteristic of anticholinesterase toxicity. The present study was conducted to determine whether the maternal deaths, clinical observations, and/or weight loss could be correlated with baseline blood cholinesterase levels in individual animals. Cholinesterase levels (plasma and erythrocyte) were obtained prior to, during, and following treatment of nonpregnant rats by gavage with 380 µg/kg/d sarin for 10 d. After the first dose, there was a drop in the plasma cholinesterase levels, which then remained low throughout the dosing period. There was a statistically significant correlation between body weight loss and plasma cholinesterase levels of the sarin dosed animals. The surviving animals also had lower plasma cholinesterase levels and lower body weights, both of which recovered on the cessation of dosing. The erythrocyte cholinesterase levels were not different between treated and nontreated rats. Neither plasma or erythrocyte baseline cholinesterase levels nor relative or absolute cholinesterase decline values could be used as predictors of mortality from sarin administration in rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SARIN
KW - RATS as laboratory animals
KW - CHOLINESTERASES
KW - TOXICOLOGY
N1 - Accession Number: 4783477; Young, John F. 1 Gough, Bobby J. 1 Suber, Robert L. 2 Gaylor, David W. 1; Affiliation: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA 2: Bowman Gray Technical Center, RJR Nabisco, Inc., Winston-Salem, North Carolina, USA; Source Info: 2001, Vol. 62 Issue 3, p161; Subject Term: SARIN; Subject Term: RATS as laboratory animals; Subject Term: CHOLINESTERASES; Subject Term: TOXICOLOGY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/009841001458280
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holman, Robert C.
AU - Curns, Aaron T.
AU - Kaufman, Stephen F.
AU - Cheek, James E.
AU - Pinner, Robert W.
AU - Schonberer, Lawrence B.
T1 - Trends in Infectious Disease Hospitalizations Among American Indians and Alaska Natives.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/03//
VL - 91
IS - 3
M3 - Article
SP - 425
EP - 431
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study sought to describe trends in hospitalizations associated with infectious diseases among American Indians and Alaska Natives. Methods. Infectious disease hospitalizations and rates among American Indians and Alaska Natives from 1980 through 1994 were examined via Indian Health Service hospital discharge data and compared with published trends for the general US population. Results. Annual hospitalization rates for infectious diseases among American Indians and Alaska Natives decreased by 31.0% between 1980 and 1994. Infectious disease hospitalizations accounted for 16.3% of all hospitalizations in 1980 and 21.2% in 1994, an increase of 30.1%. In 1994, the age-adjusted infectious disease hospitalization rate for American Indians and Alaska Natives was 1863 per 100000 population, approximately 21% greater than that for the general US population. Conclusions. Hospitalization trends for infectious diseases show that there has been improvement in the health stares of American Indians and Alaska Natives but also indicate that this population has a higher infectious disease burden than the general US population. (Am J Public Health. 2001;91:425-431) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases
KW - HOSPITAL care
KW - NATIVE Americans
KW - POPULATION
KW - UNITED States
N1 - Accession Number: 4147467; Holman, Robert C. 1 Curns, Aaron T. 1 Kaufman, Stephen F. 2 Cheek, James E. 3 Pinner, Robert W. 4 Schonberer, Lawrence B. 1; Affiliation: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Indian Health Service, Rockville, Md. 3: Epidemiology Program, Office of Public Health, Indian Health Service, Albuquerque, NM. 4: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga.; Source Info: Mar2001, Vol. 91 Issue 3, p425; Subject Term: COMMUNICABLE diseases; Subject Term: HOSPITAL care; Subject Term: NATIVE Americans; Subject Term: POPULATION; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pfefferbaum, Betty
AU - Call, John
AU - Lensgraf, S.
AU - Miller, Peteryne
AU - Flynn, Brian
AU - Doughty, Debby
AU - Tucker, Phebe
AU - Dickson, Warren
T1 - Traumatic Grief in a Convenience Sample of Victims Seeking Support Services After a Terrorist Incident.
JO - Annals of Clinical Psychiatry (Springer Science & Business Media B.V.)
JF - Annals of Clinical Psychiatry (Springer Science & Business Media B.V.)
Y1 - 2001/03//
VL - 13
IS - 1
M3 - Article
SP - 19
EP - 24
SN - 10401237
AB - This report describes traumatic grief in 40 individuals who suffered losses in the 1995 bombing of the Alfred P. Murrah Federal Building in Oklahoma City. We administered a self-report instrument 6 months after the bombing to assess demographics; exposure; injury; retrospective report of initial emotional and physiological reaction; and current posttraumatic stress symptoms, grief, safety concerns, and functioning. A strong association was found between posttraumatic stress symptoms and grief. The relationship between grief and difficulty functioning was stronger at higher levels of posttraumatic stress than at lower levels. The results support the construct of traumatic grief and have important implications for the treatment of people exposed to large-scale traumatic events and for the training of mental health professionals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Clinical Psychiatry (Springer Science & Business Media B.V.) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - bereavement
KW - disaster
KW - grief
KW - posttraumatic stress
KW - terrorism
KW - trauma
N1 - Accession Number: 50247075; Pfefferbaum, Betty 1; Email Address: betty-pfefferbaum@ouhsc.edu Call, John 2 Lensgraf, S. 1 Miller, Peteryne 1 Flynn, Brian 3 Doughty, Debby 1 Tucker, Phebe 1 Dickson, Warren 4; Affiliation: 1: Department of Psychiatry at the University of Oklahoma Health Sciences Center, Oklahoma City 2: Private Practice, Oklahoma City 3: Department of Health and Human Services, Center for Mental Health Services, Rockville 4: University of Central Oklahoma, Edmond; Source Info: Mar2001, Vol. 13 Issue 1, p19; Author-Supplied Keyword: bereavement; Author-Supplied Keyword: disaster; Author-Supplied Keyword: grief; Author-Supplied Keyword: posttraumatic stress; Author-Supplied Keyword: terrorism; Author-Supplied Keyword: trauma; Number of Pages: 6p; Document Type: Article
L3 - 10.1023/A:1009008614219
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=50247075&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Winslow, R.M.
AU - Zhu, H.
AU - Jackson, T.
AU - Bunn, F.H.
AU - Tsuchida, E.
AU - Alayash, A.I.
AU - Intaglietta, M.
AU - Johnson, P.C.
AU - Tsai, A.
AU - Chang, T.M.S.
T1 - ABSTRACTS OF PLENARY LECTURES.
JO - Artificial Cells, Blood Substitutes, & Immobilization Biotechnology
JF - Artificial Cells, Blood Substitutes, & Immobilization Biotechnology
Y1 - 2001/03//
VL - 29
IS - 2
M3 - Abstract
SP - 85
PB - Taylor & Francis Ltd
SN - 10731199
AB - Presents abstracts of research papers on blood substitutes which were presented during the eighth International Symposium on blood substitutes, that was held in San Diego, California on November 8-11, 2000. 'Blood Substitutes: Current Status and New Challenges,' by R.M. Winslow; 'Oxygen-Sensing and Oxygen-Dependent Gene Expression,' by H. Zhu, T. Jackson and F.H. Bunn; 'Recent Progress of Artificial Blood Project and Novel Products,' by E. Tsuchida.
KW - BLOOD substitutes
KW - RESEARCH
KW - CONFERENCES & conventions
N1 - Accession Number: 10468427; Winslow, R.M. 1 Zhu, H. 2 Jackson, T. 2 Bunn, F.H. 2 Tsuchida, E. 3 Alayash, A.I. 4 Intaglietta, M. 5 Johnson, P.C. 5 Tsai, A. 5 Chang, T.M.S. 6,7; Affiliation: 1: Sangart, Inc., San Diego CA 2: Division of Hematology, Brigham and Women's Hospital, Harvard Medical School 3: Department of Polymer Chemistry, ARISE, Waseda University, Tokyo, Japan 4: Center for Biologics Evaluation and Research, Food and Drug Administration 5: Department of Bioengineering, University of California 6: Artificial Cells & Organs Research Centre 7: Faculty of Medicine, McGill University; Source Info: Mar2001, Vol. 29 Issue 2, p85; Subject Term: BLOOD substitutes; Subject Term: RESEARCH; Subject Term: CONFERENCES & conventions; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 7p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clark, H. Westley
T1 - Residential Substance Abuse Treatment for Pregnant and Postpartum Women and Their Children: Treatment and Policy Implications.
JO - Child Welfare
JF - Child Welfare
Y1 - 2001/03//Mar/Apr2001
VL - 80
IS - 2
M3 - Article
SP - 179
EP - 198
PB - Child Welfare League of America
SN - 00094021
AB - In FY 1993 and FY 1995, the federal government awarded 27 five-year grants that supported 35 residential treatment projects for substance-abusing pregnant and postpartum women and their children. These projects provided comprehensive culturally and gender-specific treatment. Preliminary aggregated data collected in a national cross-site evaluation of 24 of these projects are encouraging with respect to infant mortality and morbidity, treatment retention and completion rates, and behavioral changes in the participating mothers at six months postdischarge. Local evaluations reflect other benefits of treatment. Cost data are expected to demonstrate the efficiencies and benefits of these projects compared to no treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Child Welfare is the property of Child Welfare League of America and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANT women
KW - SUBSTANCE abuse -- Treatment
KW - FAMILY services
KW - WOMEN -- Services for
KW - INFANT mortality
KW - SOCIAL services
KW - COMMUNITY-based social services
KW - HUMAN services
KW - SERVICES for
KW - UNITED States
N1 - Accession Number: 4273528; Clark, H. Westley 1; Affiliation: 1: Director, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: Mar/Apr2001, Vol. 80 Issue 2, p179; Subject Term: SUBSTANCE abuse; Subject Term: PREGNANT women; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: FAMILY services; Subject Term: WOMEN -- Services for; Subject Term: INFANT mortality; Subject Term: SOCIAL services; Subject Term: COMMUNITY-based social services; Subject Term: HUMAN services; Subject Term: SERVICES for; Subject Term: UNITED States; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 20p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5641
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ER -
TY - JOUR
AU - Humphreys, Susie H.
AU - Carrington, Clark
AU - Bolger, Michael
T1 - A quantitative risk assessment for fumonisins B[sub 1] and B[sub 2] in US corn.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2001/03//
VL - 18
IS - 3
M3 - Article
SP - 211
EP - 220
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Quantitative risk analysis permits modifying risk estimates with changes in variables such as exposure. This analysis for exposure to the mycotoxin fumonisin describes the magnitude of adverse effects, variability in the population and uncertainty of models as a range of possible outcomes. The most sensitive adverse response in rats, nephrotoxic lesions, was used for the dose-response analysis. Dietary intake of corn products was estimated from a 3-day consumption survey. Levels of corn in each product were estimated by standard methods. Fumonisin levels in corn products were estimated from Food and Drug Administration (FDA) surveillance data and distributions of fumonisin consumption were modelled for each eater in the survey population. Uncertainty for predictions made from each model and uncertainty resulting from model selection were described. Results of the dose-response and exposure analyses were assimilated in a two-dimensional Monte-Carlo simulation. Distributions representing variability and uncertainty were iteratively selected to form an array of estimates of the risk. On the basis of this analysis, current dietary levels of fumonisin would not result in renal lesions even at upper levels of exposure. To avoid toxicity at much higher doses, limiting corn intake would be more effective than would limiting the level of fumonisin in corn. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FUMONISINS
KW - RISK assessment
KW - CORN products
KW - MONTE Carlo method
KW - UNITED States
KW - Exposure assessment
KW - Monte Carlo simulation
KW - Mycotoxins
KW - NEPHROTOXICITY
N1 - Accession Number: 4273364; Humphreys, Susie H. 1 Carrington, Clark 1 Bolger, Michael 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW, Washington, DC 20204, USA; Source Info: Mar2001, Vol. 18 Issue 3, p211; Subject Term: FUMONISINS; Subject Term: RISK assessment; Subject Term: CORN products; Subject Term: MONTE Carlo method; Subject Term: UNITED States; Author-Supplied Keyword: Exposure assessment; Author-Supplied Keyword: Monte Carlo simulation; Author-Supplied Keyword: Mycotoxins; Author-Supplied Keyword: NEPHROTOXICITY; NAICS/Industry Codes: 311221 Wet Corn Milling; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1080/02652030010021486
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ER -
TY - JOUR
AU - Kodell, R. L.
AU - Young, J. F.
AU - Delongchamp, R. R.
AU - Turturro, A.
AU - Chen, J. J.
AU - Gaylor, D. W.
AU - Howard, P. C.
AU - Zheng, Q.
T1 - A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B[sub 1] in the diet.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2001/03//
VL - 18
IS - 3
M3 - Article
SP - 237
EP - 253
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Data from the National Toxicology Program's carcinogenesis study of fumonisin B[sub 1] in B6C3F[sub 1] mice, conducted at the National Center for Toxicological Research, were used to fit the Moolgavkar-Venzon-Knudson (MVK) two-stage, clonal-expansion model of carcinogenesis. In addition to tumour data from the conventional 2-year bioassay, the study included data on tissue weights, cell proliferation, cell death, and sphingolipid metabolism in primary target organs. The model was used to predict 2-year liver tumour rates in female and male mice based on differences among dose groups in the effect of fumonisin B[sub 1] on the growth of normal tissue and on the proliferation of preneoplastic cells as a compensatory response to sphinganine-induced cell death. Fumonisin B[sub 1] was assumed to be non-genotoxic, i.e. the model did not include any effect of fumonisin B[sub 1] on either of the two mutation rates of the MVK model. The model was able to reproduce reasonably well the observed tumour rates in both female and male mice, predicting substantially increased rates above background only at the highest doses of fumonisin B[sub 1] in females. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER tumors
KW - FUMONISINS
KW - PRECANCEROUS conditions
KW - COMPENSATORY PROLIFERATION
KW - MVK MODEL
KW - Non-genotoxic
KW - Sphingolipid metabolism
N1 - Accession Number: 4273360; Kodell, R. L. 1 Young, J. F. 1 Delongchamp, R. R. 1 Turturro, A. 1 Chen, J. J. 1 Gaylor, D. W. 1 Howard, P. C. 1 Zheng, Q. 1; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Mar2001, Vol. 18 Issue 3, p237; Subject Term: LIVER tumors; Subject Term: FUMONISINS; Subject Term: PRECANCEROUS conditions; Author-Supplied Keyword: COMPENSATORY PROLIFERATION; Author-Supplied Keyword: MVK MODEL; Author-Supplied Keyword: Non-genotoxic; Author-Supplied Keyword: Sphingolipid metabolism; Number of Pages: 17p; Illustrations: 2 Diagrams, 12 Graphs; Document Type: Article
L3 - 10.1080/02652030010021972
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ER -
TY - JOUR
AU - Delongchamp, R. R.
AU - Young, J. F.
T1 - Tissue sphinganine as a biomarker of fumonisin-induced apoptosis.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2001/03//
VL - 18
IS - 3
M3 - Article
SP - 255
EP - 261
PB - Taylor & Francis Ltd
SN - 0265203X
AB - NCTR measured sphinganine concentrations in the livers of mice and in the livers and kidneys of rats in conjunction with a tumour bioassay. In our model of the tumour incidence, target-tissue levels of sphinganine serve as a biomarker for a dose response of fumonisin B[sub 1] on cell death. Initially we questioned the utility of sphinganine levels in this role because they were highly variable when compared across time points. In spite of this concern, a conceptual framework and data are presented that support the use of sphinganine as a biomarker for a dose response of fumonisin B[sub 1] on cell death. This framework is reasonably consistent with observed sphinganine concentrations in the examined tissues, the literature on fumonisin's effects on sphingolipid synthesis, and our hypothesized mechanism through which fumonisin B[sub 1] increases age-specific tumour incidence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPHINGOSINE
KW - BIOCHEMICAL markers
KW - FUMONISINS
KW - CANCER MECHANISM
KW - FUMONISIN B
KW - Sphingolipid synthesis
N1 - Accession Number: 4273359; Delongchamp, R. R. 1 Young, J. F. 1; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Mar2001, Vol. 18 Issue 3, p255; Subject Term: SPHINGOSINE; Subject Term: BIOCHEMICAL markers; Subject Term: FUMONISINS; Author-Supplied Keyword: CANCER MECHANISM; Author-Supplied Keyword: FUMONISIN B; Author-Supplied Keyword: Sphingolipid synthesis; Number of Pages: 7p; Illustrations: 7 Graphs; Document Type: Article
L3 - DOI:10.1080/02652030010021981
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nelson, B. K.
AU - Snyder, D. L.
AU - Shaw, P. B.
T1 - Developmental Toxicity Interactions of Methanol and Radiofrequency Radiation or 2-Methoxyethanol in Rats.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2001/03//
VL - 20
IS - 2
M3 - Article
SP - 89
EP - 100
PB - Taylor & Francis Ltd
SN - 10915818
AB - This research was undertaken to determine potential interactions among chemical and physical agents. Radiofrequency (RF) radiation is used in numerous workplaces, and many workers are concurrently exposed to RF radiation and various chemicals. The developmental toxicity of RF radiation is associated with the degree and duration of hyperthermia induced by the exposure. Previous animal research indicates that hyperthermia induced by an elevation in ambient temperature can potentiate the toxicity and teratogenicity of some chemical agents. We previously demonstrated that combined exposure to RF radiation (10 MHz) and the industrial solvent, 2-methoxyethanol (2ME), enhanced teratogenicity in rats. Interactions were noted at even the lowest levels of 2ME tested, but only at hyperthermic levels of RF radiation. The purpose of the present research is to investigate if the interactive effects noted for RF radiation and 2ME are unique to these agents, or if similar interactions might be seen with other chemicals. Because methanol is widely used as a solvent as well as fuel additive, and, at high levels, is teratogenic in animals, we selected methanol as a chemical to address generalizability. Based on the literature and our pilot studies, 0, 2, or 3 g/kg methanol (twice, at 6-hour intervals) were administered on gestation day 9 or 13 to groups of 10 Sprague-Dawley rats. Dams treated on day 9 were given methanol and exposed to RF radiation sufficient to maintain colonic temperature at 41 ° C for 60 minutes (or sham). Those treated on day 13 were given methanol plus either 0 or 100 mg/kg 2ME. Because we observed that methanol produced hypothermia, some groups were given the initial dose of methanol concurrently with the RF or 2ME, and others were given the first dose of methanol 1.5 hours prior to RF or 2ME. Dams were sacrificed on gestation day 20, and the fetuses were examined for external malformations. The results indicate that RF radiation or methanol on day 9 increased the incidence of resorbed fetuses, but no interactive effects were observed. The resorptions were highest in groups given the experimental treatments 1.5 hours apart. The higher dose of methanol also reduced fetal weights. Administration of 2ME or methanol on day 13 increased the rate of malformations, and there was evidence of a positive interaction between 2ME and methanol. Fetal weights were reduced by 2ME and methanol alone, but no interaction was observed. Also, separation of the dosing with the teratogens did not affect the results. These results point out that interactions in developmental toxicology, such as those of RF radiation, 2ME, and methanol that we have studied, are complex, and such interactions cannot be fully understood or predicted without more research. It is important that combined exposure effects be considered when developing both physical agent and chemical agent exposure guidelines and intervention strategies. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGICAL interactions
KW - RADIATION -- Physiological effect
KW - METHANOL
KW - DEVELOPMENTAL toxicology
KW - TOXICOLOGY
KW - Exposure standards
KW - Glycol ethers
KW - Hyperthermia
KW - INDUSTRIAL SOLVENTS
KW - INTERVENTION STRATEGIES
KW - Methanol
KW - RF RADIATION
KW - Synergism
N1 - Accession Number: 4437935; Nelson, B. K. 1 Snyder, D. L. 1 Shaw, P. B. 1; Affiliation: 1: National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: Mar2001, Vol. 20 Issue 2, p89; Subject Term: TOXICOLOGICAL interactions; Subject Term: RADIATION -- Physiological effect; Subject Term: METHANOL; Subject Term: DEVELOPMENTAL toxicology; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Exposure standards; Author-Supplied Keyword: Glycol ethers; Author-Supplied Keyword: Hyperthermia; Author-Supplied Keyword: INDUSTRIAL SOLVENTS; Author-Supplied Keyword: INTERVENTION STRATEGIES; Author-Supplied Keyword: Methanol; Author-Supplied Keyword: RF RADIATION; Author-Supplied Keyword: Synergism; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/10915810151115218
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flannery, Raymond B.
AU - Fisher, William
AU - Walker, Andrew P.M.
AU - Littlewood, Karla B.
AU - Spillane, Michael J.
T1 - Nonviolent Psychiatric Inpatients and Subsequent Assaults on Community Patients and Staff.
JO - Psychiatric Quarterly
JF - Psychiatric Quarterly
Y1 - 2001/03//
VL - 72
IS - 1
M3 - Article
SP - 19
PB - Springer Science & Business Media B.V.
SN - 00332720
AB - Health care staff on psychiatric inpatient units are at high risk for work-related assaults by patients. Recent studies have begun to document similar patient assaults toward staff in community-based residences. Earlier community studies did not control for the level of patient assault prior to community discharge, and it remains unknown whether the community residence assaults were a function of community placement or a reflection of ongoing control issues by the recently discharged patients. This preliminary inquiry retrospectively tracked the nature and frequency of assaults by patients newly discharged to community residences from a state hospital setting where there had been no assaults by these patients for a two-and-one half-year period. While base rates remain to be determined, the findings in this study suggest the assaultive patients to be younger males with diagnoses of schizophrenia and histories of violence toward others, substance abuse, and violence toward self. Nine patients committed the majority of the assaults. There was a significant decline in the frequency of assaults nine months post-discharge. The implications are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychiatric Quarterly is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASSAULT & battery
KW - MENTALLY ill
KW - MENTAL health personnel
KW - community patients
KW - community residences
KW - community staff
KW - patient assaults
KW - victims
KW - workplace violence
N1 - Accession Number: 11303870; Flannery, Raymond B. 1 Fisher, William 2 Walker, Andrew P.M. 3 Littlewood, Karla B. 4 Spillane, Michael J. 4; Affiliation: 1: Department of Mental Health, and Associate Clinical Professor of Psychology, Harvard Medical School 2: The Center of Mental Health Services Research, University of Massachusetts Medical School, and Associate of Psychiatry, University of Massachusetts Medical School 3: Automated Information Technology Specialist, Massachusetts Department of Mental Health 4: The Massachusetts of Mental Health; Source Info: Mar2001, Vol. 72 Issue 1, p19; Subject Term: ASSAULT & battery; Subject Term: MENTALLY ill; Subject Term: MENTAL health personnel; Author-Supplied Keyword: community patients; Author-Supplied Keyword: community residences; Author-Supplied Keyword: community staff; Author-Supplied Keyword: patient assaults; Author-Supplied Keyword: victims; Author-Supplied Keyword: workplace violence; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jason, J.
AU - Inge, K. L.
T1 - Modulation of CD8 and CD3 by HIV or HIV Antigens.
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
Y1 - 2001/03//
VL - 53
IS - 3
M3 - Article
SP - 259
EP - 267
PB - Wiley-Blackwell
SN - 03009475
AB - To investigate whether human immunodeficiency virus (HIV)-1 and HIV-1 antigens modulate surface and cytoplasmic CD8 or CD3, as well as CD4, we used cell permeabilization reagents, surface/cytoplasmic fluorescent staining, multiparameter flow cytometric techniques and an in vitro culture system in which relatively few lymphocytes are actively infected with HIV. Human peripheral blood lymphocytes were: not stimulated, not stimulated but HIV-inoculated, phytohaemagglutinin (PHA)-stimulated, PHA/HIV-inoculated (PHA/HIV), or placed into media with soluble gp120, Rev or Nef. HIV inoculation and Nef had striking modulatory effects on CD8. The cytoplasmic CD8 median fluorescent intensity (MFI) of positive lymphocytes was lower for cells in unstimulated/HIV-infected cultures than unstimulated cultures (44 versus 62% of ex vivo value, P = 0.032) and lower for cells in PHA/HIV cultures than in PHA cultures (56 versus 100% of ex vivo, P = 0.041). The surface CD8 MFI values for Nef were significantly lower than the ex vivo value (75% of ex vivo, P = 0.006). At days 2–7 of culture, Rev was associated with slight reductions in surface CD4 MFI (58% of ex vivo versus 78% of ex vivo for unstimulated cultures, P = 0.047) and greater effects on cytoplasmic CD3 MFI (131 versus 179% of ex vivo for unstimulated cultures, P = 0.035), and surface CD8 MFI (70% of ex vivo, P = 0.006 versus ex vivo value). The globality of Rev's effects suggests these are related to a shared processing pathway, i.e. not due to direct interaction with CD3, CD4 and CD8; the effects of HIV inoculation and Nef on CD8 expression appear to be more CD8 specific. Because CD8 is essential for cytotoxic T-cell function, its down-modulation could inhibit this activity, including anti-HIV cytotoxicity. Given the critical roles of CD3 and CD8 in T-lymphocyte signal transduction and antigen responsiveness, the effects of HIV, Rev and Nef on these molecules have clinically significant implications concerning the pathogenesis and treatment of HIV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CD antigens
KW - HIV (Viruses)
KW - CYTOPLASM
KW - LYMPHOCYTES
N1 - Accession Number: 5509052; Jason, J. 1 Inge, K. L. 1; Affiliation: 1: Immunology Branch, Division of AIDS, Sexually Transmitted Diseases, and Tuberculosis, Laboratory Research (DASTLR), National Center for Infectious Diseases, Centers for Disease, Control and Prevention (CDC), Department of Health and Human Services, Public Health Service, Atlanta, GA, USA; Source Info: Mar2001, Vol. 53 Issue 3, p259; Subject Term: CD antigens; Subject Term: HIV (Viruses); Subject Term: CYTOPLASM; Subject Term: LYMPHOCYTES; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-3083.2001.00871.x
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ER -
TY - JOUR
AU - Faroon, Obaid M
AU - Keith, Sam
AU - Jones, Dennis
AU - de Rosa, Christopher
T1 - Carcinogenic effects of polychlorinated biphenyls.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/03//
VL - 17
IS - 2
M3 - Article
SP - 41
EP - 62
PB - Sage Publications, Ltd.
SN - 07482337
AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of an important section of the Toxicological profile for polychlorinated biphenyls [ATSDR. 2000: Toxicological profile for polychlorinated biphenyls. Atlanta, GA: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry.] into the scientific literature. This article focuses on the carcinogenic effects of this group of synthetic organic chemicals (polychlorinated biphenyls) in humans and animals. Information on other health effects, toxicokinetics, mechanisms of toxicity, biomarkers, interactions, chemical and physical properties, potential for human exposure, and regulations and advisories is detailed in the profile. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIPHENYL compounds
KW - CANCER
KW - Biliary tract cancer
KW - BREAST CANCER
KW - Congener
KW - Liver cancer
KW - MIXTURES
KW - Non-Hodgkin's lymphoma
KW - PCBS
KW - Skin cancer
N1 - Accession Number: 6943009; Faroon, Obaid M 1 Keith, Sam 1 Jones, Dennis 1 de Rosa, Christopher 1; Affiliation: 1: Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, Georgia 30333, USA; Source Info: 2001, Vol. 17 Issue 2, p41; Subject Term: BIPHENYL compounds; Subject Term: CANCER; Author-Supplied Keyword: Biliary tract cancer; Author-Supplied Keyword: BREAST CANCER; Author-Supplied Keyword: Congener; Author-Supplied Keyword: Liver cancer; Author-Supplied Keyword: MIXTURES; Author-Supplied Keyword: Non-Hodgkin's lymphoma; Author-Supplied Keyword: PCBS; Author-Supplied Keyword: Skin cancer; Number of Pages: 22p; Document Type: Article
L3 - 10.1191/0748233701th098oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Darby, Charles
T1 - Commentary.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2001/03/02/Supplement 1
VL - 58
IS - S1
M3 - Article
SP - 67
EP - 69
SN - 10775587
N1 - Accession Number: 54898134; Darby, Charles 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Supplement 1, Vol. 58 Issue S1, p67; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1192
L3 - 10.1177/107755870105800108
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ER -
TY - JOUR
AU - Schwetz, Bernard A.
AU - Schwetz, B A
T1 - From the Food and Drug Administration.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2001/03/07/
VL - 285
IS - 9
M3 - journal article
SP - 1146
EP - 1146
SN - 00987484
AB - Presents medical news briefs from the United States Food and Drug Administration. Development of a revised informed consent form and medication guide to strengthen protection for patients who use isotretinoin (Accutane); Approval of an indication for letrozole as a first-line treatment for post-menopausal women with hormone receptor-positive or breast cancer; Approval of mesalamine rectal suppositories; Others.
KW - ISOTRETINOIN
KW - BREAST cancer -- Treatment
KW - SUPPOSITORIES
KW - ANTINEOPLASTIC agents -- Therapeutic use
KW - HETEROCYCLIC compounds
KW - ORGANIC compounds
KW - BREAST tumors
KW - CLINICAL trials
KW - DERMATOLOGIC agents
KW - INFORMATION services
KW - NONSTEROIDAL anti-inflammatory agents
KW - ULCERATIVE colitis
KW - RELATIVE risk (Medicine)
KW - MESALAMINE
KW - THERAPEUTIC use
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 4166011; Schwetz, Bernard A. Schwetz, B A 1; Affiliation: 1: Food and Drug Administration, USA; Source Info: 3/7/2001, Vol. 285 Issue 9, p1146; Subject Term: ISOTRETINOIN; Subject Term: BREAST cancer -- Treatment; Subject Term: SUPPOSITORIES; Subject Term: ANTINEOPLASTIC agents -- Therapeutic use; Subject Term: HETEROCYCLIC compounds; Subject Term: ORGANIC compounds; Subject Term: BREAST tumors; Subject Term: CLINICAL trials; Subject Term: DERMATOLOGIC agents; Subject Term: INFORMATION services; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: ULCERATIVE colitis; Subject Term: RELATIVE risk (Medicine); Subject Term: MESALAMINE; Subject Term: THERAPEUTIC use; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ivanoff, Carl-Johan
AU - Widmark, Göran
AU - Hallgren, Carin
AU - Sennerby, Lars
AU - Wennerberg, Ann
T1 - Histologic evaluation of the bone integration of TiO2 blasted and turned titanium microimplants in humans.
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
Y1 - 2001/04//
VL - 12
IS - 2
M3 - Article
SP - 128
EP - 134
SN - 09057161
AB - Abstract: Twenty-seven patients received 2 microimplants each during implant surgery. One microimplant was blasted with 25 μm sized particles of TiO2; the other was left as machined i.e. a turned surface. Before insertion the surface topography was characterized with an optical confocal laser profilometer. The surface roughness was greater than standard implants, and was similar for both surface modifications averaging over all parts of the implant i.e. tops, valley and flanks. The mean surface roughness from flank measurements only replicated previously reported findings: i.e. significantly rougher surfaces on blasted implants. After a mean healing period of 6.3 months in the maxillae and 3.9 months in the mandible, the microimplants and surrounding tissue were removed with a trephine burr. The histomorphometrical evaluation demonstrated significantly higher bone-to-implant contact for the blasted implants, inserted in the maxilla or in the mandible. Significantly more bone was found inside the threaded area for the blasted implants in the mandible, but there was no difference for implants positioned in maxillae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Oral Implants Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL implants
KW - OSSEOINTEGRATION
KW - bone healing
KW - histomorphometry
KW - Surface characterization
KW - surface modification
KW - titanium implants
N1 - Accession Number: 5789150; Ivanoff, Carl-Johan 1,2 Widmark, Göran 1 Hallgren, Carin 2,3 Sennerby, Lars 2,4 Wennerberg, Ann 2,3; Affiliation: 1: Department of Oral and Maxillofacial Surgery, Mölndal Hospital, Mölndal 2: Department of Biomaterials/Handicap Research and Institute for Surgical Sciences, Göteborg University, Faculty of Medicine, Göteborg 3: Department of Prosthetic Dentistry/Dental Material Sciences, Faculty of Odontology, Göteborg University 4: Brånemark Clinic, Public Health Service, Göteborg City, Göteborg, Sweden; Source Info: Apr2001, Vol. 12 Issue 2, p128; Subject Term: DENTAL implants; Subject Term: OSSEOINTEGRATION; Author-Supplied Keyword: bone healing; Author-Supplied Keyword: histomorphometry; Author-Supplied Keyword: Surface characterization; Author-Supplied Keyword: surface modification; Author-Supplied Keyword: titanium implants; Number of Pages: 7p; Document Type: Article
L3 - 10.1034/j.1600-0501.2001.012002128.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hallman, Mats
AU - Cederlund, Andreas
AU - Lindskog, Sven
AU - Lundgren, Stefan
AU - Sennerby, Lars
T1 - A clinical histologic study of bovine hydroxyapatite in combination with autogenous bone and fibrin glue for maxillary sinus floor augmentation.
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
Y1 - 2001/04//
VL - 12
IS - 2
M3 - Article
SP - 135
EP - 143
SN - 09057161
AB - Abstract: Biopsies were taken from 16 out of 20 consecutive referral patients 6 to 8 months after maxillary sinus floor augmentation with a mixture of bovine hydroxyapatite (BH), autogenous bone particles and fibrin glue. Four days prior to biopsy retrieval the patients were given a single dose of tetracyclin to label bone forming sites. Fluorescence microscopy of 100 μm thick sections revealed active bone formation in conjunction with the BH particles in 14 of 15 specimens analysed. Light microscopy and morphometry of ground sections from 16 patients showed various amounts of mineralised bone tissue in all except one specimen. In the latter case, the BH particles were encapsulated by a dense fibrous connective tissue. Sections from the augmented areas were occupied by non-mineralized tissue (54.1+12.6%), lamellar bone (21.2+24.5%), BH particles (14.5+10.3%) and woven bone (10.2+13.4%). The non-mineralized tissue seen in bone forming areas consisted of a loose connective tissue, rich of vessels and cells, and in the periphery of a more dense fibrous connective tissue. Woven bone with large and scattered osteocyte lacunae was bridging between the BH particles and the lamellar trabecular bone. There were no signs of resorption of the BH particles. The lamellar bone appeared to have originated from the recipient site and was seldom in contact with the BH particles. It is concluded that the tested implant material has bone conducting properties. The bone associated with the BH particles after 6 to 8 months of healing was mainly woven. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Oral Implants Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROXYAPATITE
KW - BONE-grafting
KW - autogenous bone graft
KW - bovine hydroxyapatite
KW - clinical study
KW - fibrin glue
KW - histology
KW - maxillary sinus floor augmentation
N1 - Accession Number: 5789149; Hallman, Mats 1 Cederlund, Andreas 2 Lindskog, Sven 2 Lundgren, Stefan 3 Sennerby, Lars 4; Affiliation: 1: Clinic for Oral & Maxillofacial Surgery, Public Health Service, Gävle City and Dept of Oral & Maxillofacial Surgery, Umeå University, Umeå 2: Dept of Oral Pathology, the Karolinska Institute, Huddinge 3: Dept of Oral & Maxillofacial Surgery, Umeå University, Umeå 4: Dept of Biomaterials/Handicap Research, Institute for Surgical Sciences and the Brånemark Clinic, Göteborg University, Göteborg, Sweden; Source Info: Apr2001, Vol. 12 Issue 2, p135; Subject Term: HYDROXYAPATITE; Subject Term: BONE-grafting; Author-Supplied Keyword: autogenous bone graft; Author-Supplied Keyword: bovine hydroxyapatite; Author-Supplied Keyword: clinical study; Author-Supplied Keyword: fibrin glue; Author-Supplied Keyword: histology; Author-Supplied Keyword: maxillary sinus floor augmentation; Number of Pages: 9p; Document Type: Article
L3 - 10.1034/j.1600-0501.2001.012002135.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neriishi, K.
AU - Nakashima, E.
AU - Delongchamp, R. R.
T1 - Persistent subclinical inflammation among A-bomb survivors.
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
Y1 - 2001/04//
VL - 77
IS - 4
M3 - Article
SP - 475
EP - 482
PB - Taylor & Francis Ltd
SN - 09553002
AB - Purpose: To investigate the associations between inflammation tests and radiation dose in A-bomb survivors. Subjects and methods: Subjects were A-bomb survivors who underwent inflammation tests of leukocyte counts, neutrophil counts, erythrocyte sedimentation rate, corrected erythrocyte sedimentation rate, α-1 globulin, α-2 globulin and sialic acid between 1988 and 1992. Associations with radiation dose (DS86) were analyzed by regression analysis and heterogeneity among inflammatory diseases, anaemia at examination, or history of cancer was also tested. Results: The associations with radiation dose were statistically significant for leukocyte counts (71.0mm[sup -3] Gy[sup -1], p=0.015), erythrocyte sedimentation rate (1.58mm h[sup -1] Gy[sup -1], p=0.0001), corrected erythrocyte sedimentation rate (1.14 mm h[sup -1] Gy[sup -1], p=0.0001), α-1 globulin (0.0057 g dl[sup -1] Gy[sup -1], p=0.0001), α-2 globulin (0.0128 g dl[sup -1] Gy[sup -1], p=0.0001), and sialic acid (1.2711 mg dl[sup -1] Gy[sup -1], p=0.0001) but not for neutrophil counts (29.9mm[sup -3] Gy[sup -1], p=0.17). Heterogeneity was not statistically significant. Among inflammatory diseases, associations were the strongest for chronic thyroiditis and chronic liver diseases. Conclusions: This study suggests statistically significant association between inflammation in A-bomb survivors and radiation dose of during 1988-1992. The association might contribute, as an epigenetic and/or bystander effect, to development of several radiation-induced disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Radiation Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATOMIC bomb
KW - INFLAMMATION
KW - RADIATION carcinogenesis
KW - JAPAN
N1 - Accession Number: 5171945; Neriishi, K. 1 Nakashima, E. 2 Delongchamp, R. R. 3; Affiliation: 1: Department of Clinical Studies, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Hiroshima, 732-0815, Japan 2: Department of Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Hiroshima, 732-0815, Japan 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Apr2001, Vol. 77 Issue 4, p475; Subject Term: ATOMIC bomb; Subject Term: INFLAMMATION; Subject Term: RADIATION carcinogenesis; Subject Term: JAPAN; Number of Pages: 8p; Illustrations: 5 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/09553000010024911
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Castelo, M. M.
AU - Jackson, L. S.
AU - Hanna, M. A.
AU - Reynolds, B. H.
AU - Bullerman, L. B.
T1 - Loss of Fuminosin B1 in Extruded and Baked Corn-Based Foods with Sugars.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2001/04//
VL - 66
IS - 3
M3 - Article
SP - 416
EP - 421
SN - 00221147
AB - The objective of this work was to determine the effect of added sugars on fumonisin B1 (F1) levels in baked corn muffins and extruded corn grits. Muffins containing added glucose had significantly lower F1 levels than muffins with sucrose, fructose, or no added sugar. Extrusion cooking of the grits resulted in significant (p<0.05) reductions of FB1 in all treatments relative to unextruded controls, but use of glucose resulted in greater reductions of FB1 (45.3 to 71%) than did the use of fructose (29.5 to 53%) or sucrose (19.2 to 39%). When extrusion conditions were optimized, 92.1% loss of FB1 was found when grits were extruded with glucose. Adding glucose to thermally processed food can result in a substantial reduction in FB1 levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUGARS
KW - FUMONISINS
KW - GLUCOSE
KW - BAKED products
KW - CORN
KW - FRUCTOSE
KW - SUCROSE
KW - corn
KW - extrusion
KW - fumonisin
KW - glucose
N1 - Accession Number: 28655987; Castelo, M. M. 1 Jackson, L. S. 2 Hanna, M. A. 3 Reynolds, B. H. 4 Bullerman, L. B. 5; Email Address: lbullerman1@unl.edu; Affiliation: 1: Lopez Foods, Inc., 9500 NW 4th St., Oklahoma City, Okla. 2: National Center for Food Safety and Technology, Food and Drug Administration, Summit-Argo, Ill. 3: Deparment of Biological System Engineering, University of Nebraska-Lincoln, Lincoln, Ne. 4: National Center for Food Safety and Technology, Illinois Institute of Technology, Summit-Argo, Ill. 5: Dept. of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Ne.; Source Info: Apr2001, Vol. 66 Issue 3, p416; Subject Term: SUGARS; Subject Term: FUMONISINS; Subject Term: GLUCOSE; Subject Term: BAKED products; Subject Term: CORN; Subject Term: FRUCTOSE; Subject Term: SUCROSE; Author-Supplied Keyword: corn; Author-Supplied Keyword: extrusion; Author-Supplied Keyword: fumonisin; Author-Supplied Keyword: glucose; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 445291 Baked Goods Stores; NAICS/Industry Codes: 311821 Cookie and Cracker Manufacturing; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 311813 Frozen Cakes, Pies, and Other Pastries Manufacturing; NAICS/Industry Codes: 311812 Commercial Bakeries; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111150 Corn Farming; Number of Pages: 6p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wetter, Donald Clark
AU - Daniell, William Edward
AU - Treser, Charles David
T1 - Hospital Preparedness for Victims of Chemical or Biological Terrorism.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/05//
VL - 91
IS - 5
M3 - Article
SP - 710
EP - 716
PB - American Public Health Association
SN - 00900036
AB - Conclusions. Hospital emergency departments generally are not prepared in an organized fashion to treat victims of chemical or biological terrorism. The planned federal efforts to improve domestic preparedness will require substantial additional resources at the local level to be truly effective. (Am J Public Health. 2001;91:710-716) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL emergency services
KW - PREPAREDNESS
KW - BIOTERRORISM
KW - CHEMICAL warfare
KW - MEDICAL emergencies
KW - HOSPITALS
N1 - Accession Number: 5151770; Wetter, Donald Clark 1; Email Address: dwetter@hrsa.gov Daniell, William Edward 2 Treser, Charles David 2; Affiliation: 1: Office of Emergency Preparedness US Public Health Service Region II, New York, NY 2: Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle; Source Info: May2001, Vol. 91 Issue 5, p710; Subject Term: HOSPITAL emergency services; Subject Term: PREPAREDNESS; Subject Term: BIOTERRORISM; Subject Term: CHEMICAL warfare; Subject Term: MEDICAL emergencies; Subject Term: HOSPITALS; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 6285
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCawley, Michael A.
AU - Kent, Michael S.
AU - Berakis, Michael T.
T1 - Ultrafine Beryllium Number Concentration as a Possible Metric for Chronic Beryllium Disease Risk.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/05//
VL - 16
IS - 5
M3 - Article
SP - 631
EP - 638
SN - 1047322X
AB - Beryllium is a lightweight metal which causes a chronic granulomatous lung disease among workers who become sensitized to it. Recent research has shown a persistence of the disease despite efforts at control with mean exposures below the Occupational Safety and Health Administration (OSHA) occupational exposure limit of 2 μg/m[sup 3]. Results of our current research confirm a previous finding in certain plants that particle number concentrations are higher in areas where historical estimate of risk showed a high risk of disease despite relatively lower mass concentrations. By providing side-by-side measurements of both particle number and mass, this research adds support to the proposal that particle number rather than particle mass may be more reflective of target organ dose and subsequently a more appropriate measure of exposure for chronic beryllium disease. Our evidence also shows that particle mass exposure measurements and particle number exposure measurements were not correlated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BERYLLIUM
KW - CHRONIC granulomatous disease
KW - LUNG diseases
KW - UNITED States
KW - Beryllium
KW - BERYLLIUM SENSITIZATION
KW - Chronic beryllium disease
KW - Lung deposition
KW - Occupational exposure
KW - PARTICLE SIZE
KW - ULTRAFINE AEROSOL
N1 - Accession Number: 5171730; McCawley, Michael A. 1 Kent, Michael S. 2 Berakis, Michael T. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Brush Wellman, Inc., Elmore, Ohio; Source Info: May2001, Vol. 16 Issue 5, p631; Subject Term: BERYLLIUM; Subject Term: CHRONIC granulomatous disease; Subject Term: LUNG diseases; Subject Term: UNITED States; Author-Supplied Keyword: Beryllium; Author-Supplied Keyword: BERYLLIUM SENSITIZATION; Author-Supplied Keyword: Chronic beryllium disease; Author-Supplied Keyword: Lung deposition; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: PARTICLE SIZE; Author-Supplied Keyword: ULTRAFINE AEROSOL; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 8p; Illustrations: 1 Chart, 13 Graphs; Document Type: Article
L3 - 10.1080/104732201750169778
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Mingjie
AU - Li, Xingxiang
AU - Pang, Xiaowu
AU - Ding, Linna
AU - Wood, Owen
AU - Clouse, Kathlene
AU - Hewlett, Indira
AU - Dayton, Andrew I.
T1 - Identification of a Potential HIV-Induced Source of Bystander-Mediated Apoptosis in T Cells: Upregulation of TRAIL in Primary Human Macrophages by HIV-1 Tat.
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
Y1 - 2001/05//
VL - 8
IS - 3
M3 - Article
SP - 290
EP - 296
PB - BioMed Central
SN - 10217770
AB - The induction of apoptosis in T cells by bystander cells has been repeatedly implicated as a mechanism contributing to the T cell depletion seen in HIV infection. It has been shown that apoptosis could be induced in T cells from asymptomatic HIV-infected individuals in a Fas-independent, TNF-related apoptosis-inducing ligand (TRAIL)-dependent manner if the cells were pretreated with anti-CD3. It has also been shown that T cells from HIV-infected patients were even more sensitive to TRAIL induction of apoptosis than they were to Fas induction. Recently, it has been reported that in an HIV-1 SCID-Hu model, the vast majority of the T cell apoptosis is not associated with p24 and is therefore produced by bystander effects. Furthermore, few apoptotic cells were associated with neighboring cells which were positive for either Fas ligand or TNF. However, most of the apoptotic cells were associated with TRAIL-positive cells. The nature of these TRAIL-positive cells was undetermined. Here, we report that HIV infection of primary human macrophages switches on abundant TRAIL production both at the RNA and protein levels. Furthermore, more macrophages produce TRAIL than are infected by HIV, indicating that a bystander mechanism may, at least in part, upregulate TRAIL. Exogenously supplied HIV-1 Tat protein upregulates TRAIL production by primary human macrophages to an extent indistinguishable from infection. The results suggest a model in which HIV-1-infected cells produce extracellular Tat protein, which in turn upregulates TRAIL in macrophages which then can induce apoptosis in bystander T cells.Copyright © 2001 National Science Council, ROC and S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - T cells
KW - MACROPHAGES
KW - CELL death
KW - HIV infections
KW - Apoptosis
KW - HIV
KW - Macrophage
KW - Tat
KW - TRAIL
N1 - Accession Number: 11372223; Zhang, Mingjie 1 Li, Xingxiang 1 Pang, Xiaowu 1 Ding, Linna 1 Wood, Owen 1 Clouse, Kathlene 2 Hewlett, Indira 1 Dayton, Andrew I. 1; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review 2: Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, Md., USA; Source Info: 2001, Vol. 8 Issue 3, p290; Subject Term: APOPTOSIS; Subject Term: T cells; Subject Term: MACROPHAGES; Subject Term: CELL death; Subject Term: HIV infections; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Macrophage; Author-Supplied Keyword: Tat; Author-Supplied Keyword: TRAIL; Number of Pages: 7p; Document Type: Article
L3 - 10.1159/000054045
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verthelyi, D.
AU - Petri, M.
AU - Ylamus, M.
AU - Klinman, D.
T1 - Disassociation of sex hormone levels and cytokine production in SLE patients.
JO - Lupus
JF - Lupus
Y1 - 2001/05//
VL - 10
IS - 5
M3 - Article
SP - 352
EP - 358
PB - Sage Publications Inc.
SN - 09612033
AB - This study examines whether changes in the cytokine milieu of patients with systemic lupus erythematosus (SLE) are associated with abnormal levels of sex hormone levels in serum.'The'con"centration of 17β-estradiol (E2), progesterone (Pg) and dehydroepiandrosterone-sulphate (DHEAS) was monitored in sera from 128 lupus patients and 96 controls, and correlated with the activity of their cytokine secreting cells. Results indicate that SLE patients have (i) significantly fewer cells secreting IFNγ, (ii) increased serum E2 and Pg levels, and (iii) reduced serum DHEAS levels compared to normal controls. However, the observed abnormalities in the cytokine milieu of SLE patients did not correlate with abnormalities in serum sex hormone levels. Instead, the association between IFNγ production and DHEAS levels evident in healthy controls is absent in SLE patients, suggesting that cells from lupus patients are defective in their ability to produce IFNγ in response to physiologic stimuli. Similarly, the normal correlation between IL-4 production and E2 levels was lost in patients with severe disease. Thus, while it remains possible that increased E2 and reduced DHEAS levels in lupus patients may help induce cytokine abnormalities early in disease, the subsequent cytokine imbalance does not correlate with sex hormone levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - SEX hormones
KW - cytokines
KW - dehydroepiandrosterone-sulphate
KW - estrogen
KW - Systemic lupus erythematosus
N1 - Accession Number: 4524507; Verthelyi, D. 1 Petri, M. 2 Ylamus, M. 2 Klinman, D. 1; Affiliation: 1: Retroviral Immunology Section, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA 2: Division of Rheumatology of the, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Source Info: May2001, Vol. 10 Issue 5, p352; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: SEX hormones; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: dehydroepiandrosterone-sulphate; Author-Supplied Keyword: estrogen; Author-Supplied Keyword: Systemic lupus erythematosus; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bacon, David J.
AU - Szymanski, Christine M.
AU - Burr, Don H.
AU - Silver, Richard P.
AU - Alm, Richard A.
AU - Guerry, Patricia
T1 - A phase-variable capsule is involved in virulence of Campylobacter jejuni 81-176.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2001/05//
VL - 40
IS - 3
M3 - Article
SP - 769
EP - 777
PB - Wiley-Blackwell
SN - 0950382X
AB - Campylobacter jejuni strain 81-176 (HS36, 23) synthesizes two distinct glycan structures, as visualized by immunoblotting of proteinase K-digested whole-cell preparations. A site-specific insertional mutant in the kpsM gene results in loss of expression of a high-molecular-weight (HMW) glycan (apparent Mr 26 kDa to > 85 kDa) and increased resolution of a second ladder-like glycan (apparent Mr 26–50 kDa). The kpsM mutant of 81-176 is no longer typeable in either HS23 or HS36 antisera, indicating that the HMW glycan structure is the serodeterminant of HS23 and HS36. Both the kpsM-dependent HMW glycan and the kpsM-independent ladder-like structure appear to be capsular in nature, as both are attached to phospholipid rather than lipid A. Additionally, the 81-176 kpsM gene can complement a deletion in Escherichia coli kpsM, allowing the expression of an α2,8 polysialic acid capsule in E. coli. Loss of the HMW glycan in 81-176 kpsM also increases the surface hydrophobicity and serum sensitivity of the bacterium. The kpsM mutant is also significantly reduced in invasion of INT407 cells and reduced in virulence in a ferret diarrhoeal disease model. The expression of the kpsM-dependent capsule undergoes phase variation at a high frequency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER jejuni
KW - VIRULENCE (Microbiology)
KW - GENETICS
N1 - Accession Number: 4537954; Bacon, David J. 1 Szymanski, Christine M. 1 Burr, Don H. 2 Silver, Richard P. 3 Alm, Richard A. 4 Guerry, Patricia 1; Affiliation: 1: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. 2: Food and Drug Administration, Laurel, MD, USA. 3: Department of Microbiology, University of Rochester, Rochester, NY, USA. 4: Astra Zeneca Boston, Waltham, MA, USA.; Source Info: May2001, Vol. 40 Issue 3, p769; Subject Term: CAMPYLOBACTER jejuni; Subject Term: VIRULENCE (Microbiology); Subject Term: GENETICS; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2958.2001.02431.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feinian Chen
AU - Bollen, Kenneth A.
AU - Paxton, Pamela
AU - Curran, Patrick J.
AU - Kirby, James B.
T1 - Improper Solutions in Structural Equation Models.
JO - Sociological Methods & Research
JF - Sociological Methods & Research
Y1 - 2001/05//
VL - 29
IS - 4
M3 - Article
SP - 468
SN - 00491241
AB - In this article, the authors examine the most common type of improper solutions: zero or negative error variances. They address the causes of, consequences of, and strategies to handle these issues. Several hypotheses are evaluated using Monte Carlo simulation models, including two structural equation models with several misspecifications of each model. Results suggested several unique findings. First, increasing numbers of omitted paths in the measurement model were associated with decreasing numbers of improper solutions. Second, bias in the parameter estimates was higher in samples with improper solutions than in samples including only proper solutions. Third, investigation of the consequences of using constrained estimates in the presence of improper solutions indicated that inequality constraints helped some samples achieve convergence. Finally, the use of confidence intervals as well as four other proposed tests yielded similar results when testing whether the error variance was greater than or equal to zero. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methods & Research is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIOLOGY -- Statistical methods
KW - STATISTICAL hypothesis testing
KW - ESTIMATION theory
KW - SAMPLING (Statistics)
KW - SIMULATION methods & models
KW - MONTE Carlo method
KW - SOCIAL sciences -- Methodology
N1 - Accession Number: 4352631; Feinian Chen 1 Bollen, Kenneth A. 1 Paxton, Pamela 2 Curran, Patrick J. 1 Kirby, James B. 3; Affiliation: 1: University of North Carolina at Chapel Hill. 2: Ohio State University. 3: Agency for Healthcare Research and Quality.; Source Info: May2001, Vol. 29 Issue 4, p468; Subject Term: SOCIOLOGY -- Statistical methods; Subject Term: STATISTICAL hypothesis testing; Subject Term: ESTIMATION theory; Subject Term: SAMPLING (Statistics); Subject Term: SIMULATION methods & models; Subject Term: MONTE Carlo method; Subject Term: SOCIAL sciences -- Methodology; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 41p; Illustrations: 2 Diagrams, 7 Graphs; Document Type: Article; Full Text Word Count: 13236
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, John F.
AU - Wosilait, Walter D.
AU - Luecke, Richard H.
T1 - Analysis of Methylmercury Disposition in Humans Utilizing A PBPK Model and Animal Pharmacokinetic Data.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2001/05/11/
VL - 63
IS - 1
M3 - Article
SP - 19
EP - 52
SN - 15287394
AB - Physiologically based pharmacokinetic (PBPK) models are excellent tools to aid in the extrapolation of animal data to humans. When the fate of the chemical is the same among species being compared, animal data can appropriately be considered as a model for human exposure. For methylmercury exposure, sufficient data exist to allow comparison of numerous mammalian species to humans. PBPK model validation entails obtaining blood and tissue concentrations of the parent chemical and metabolite(s) at various times following a known exposure. From ethical and practical considerations, human tissue concentrations following a known exposure to an environmental toxicant are scarce. While animal-to-human extrapolation demands that sufficient human data exist to validate the model, the validation requirements are less stringent if multiple animal models are utilized within a single model template. A versatile PBPK model was used to analyze the distribution and elimination of methylmercury and its metabolite, inorganic mercury. Uniquely, the model is formed in a generic way from a single basic template during the initial program compilation. Basic parameters are defined for different PBPK models for mammalian species that span a relatively large range of sizes. In this article, the analyses include 12 species (mouse, hamster, rat, guinea pig, cat, rabbit, monkey, sheep, pig, goat, cow, and human). Allometric (weight-based) correlations of tissue binding coefficients, metabolism rate constants, and elimination parameters for both methylmercury and inorganic mercury are presented for species for which sufficient data are available. The resulting human model, in accord with the animal models, predicts relatively high inorganic mercury levels in the kidneys long after the disappearance of methylmercury from the blood. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLMERCURY
KW - PHARMACOKINETICS
N1 - Accession Number: 5801868; Young, John F. 1 Wosilait, Walter D. 2 Luecke, Richard H. 3; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas, USA 2: Department of Pharmacology, School of Medicine, University of Missouri–Columbia, Columbia, Missouri, USA 3: Department of Chemical Engineering, University of Missouri–Columbia, Columbia, Missouri, USA; Source Info: 2001, Vol. 63 Issue 1, p19; Subject Term: METHYLMERCURY; Subject Term: PHARMACOKINETICS; Number of Pages: 34p; Document Type: Article
L3 - 10.1080/152873901750128344
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boucher, Philip E.
AU - Yang, Mei-Shin
AU - Stibitz, Scott
T1 - Mutational analysis of the high-affinity BvgA binding site in the fha promoter of Bordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2001/05/15/
VL - 40
IS - 4
M3 - Article
SP - 991
EP - 999
PB - Wiley-Blackwell
SN - 0950382X
AB - In order to define a consensus binding sequence for the response regulator BvgA, we have undertaken a systematic analysis of contributions made by each nucleotide within the heptad half-sites that are present in an inverted orientation at the promoter for the fha operon. Using in vitro binding assays, we examined the full complement of 21 single point mutations symmetrically arranged in this heptad repeat. Both gel shift and nitrocellulose filter-binding assays provided evidence that nucleotides at positions 3 (thymidine), 4 (cytosine) and 7 (adenine) in the binding heptad contribute substantially to sequence-specific recognition by BvgA. Furthermore, a T to A conversion at position 6 reduced binding. Selected binding site mutations were introduced into a modified fha promoter and examined for their effects on BvgA activation of promoter activity in vivo. Only those substitutions most severely affecting binding in vitro affected promoter activity in vivo. The in vivo effects of substitutions that had a significant effect on binding in vitro but did not severely affect in vivo promoter activity under standard culture conditions could be detected in vivo either in combination with additional substitutions or from their effect on the sensitivity of the mutant promoters to modulation by magnesium sulphate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - NUCLEOTIDE sequence
KW - GENETIC regulation
KW - BORDETELLA pertussis
KW - BINDING sites (Biochemistry)
N1 - Accession Number: 5170078; Boucher, Philip E. Yang, Mei-Shin 1 Stibitz, Scott 1; Affiliation: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA.; Source Info: May2001, Vol. 40 Issue 4, p991; Subject Term: PROTEINS; Subject Term: NUCLEOTIDE sequence; Subject Term: GENETIC regulation; Subject Term: BORDETELLA pertussis; Subject Term: BINDING sites (Biochemistry); Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2958.2001.02442.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Craft, Edwin M.
AU - Mulvey, Kevin P.
T1 - Addressing Lesbian, Gay, Bisexual, and Transgender Issues From the Inside: One Federal Agency's Approach.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/06//
VL - 91
IS - 6
M3 - Article
SP - 889
EP - 891
PB - American Public Health Association
SN - 00900036
AB - SAMHSA works in partnership with states, communities, and private organizations to address the needs of people with substance abuse and mental illnesses as well as the community risk factors that contribute to these illnesses. As part of its efforts to address the unique needs of special populations, SAMHSA has reached out to the lesbian, gay, bisexual, and transgender (LGBT) community. SAMHSA and its centers (Center for Substance Abuse Treatment, Center for Substance Abuse Prevention, and Center for Mental Health Services) have made a concerted effort, through both policy and programs, to develop services responsive to this community. (Am J Public Health. 2001;91:889-891) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- United States
KW - LGBT community health services
KW - GOVERNMENT agencies
KW - MEDICALLY underserved areas
KW - SUBSTANCE abuse
KW - UNITED States
KW - UNITED States. Substance Abuse & Mental Health Services Administration
N1 - Accession Number: 4528242; Craft, Edwin M. 1; Email Address: ecraft@samhsa.gov Mulvey, Kevin P. 1; Affiliation: 1: Substance Abuse and Mental Health Services Administration, and the US Department of Health and Human Services, Rockville, Md.; Source Info: Jun2001, Vol. 91 Issue 6, p889; Subject Term: MEDICAL care -- United States; Subject Term: LGBT community health services; Subject Term: GOVERNMENT agencies; Subject Term: MEDICALLY underserved areas; Subject Term: SUBSTANCE abuse; Subject Term: UNITED States; Company/Entity: UNITED States. Substance Abuse & Mental Health Services Administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2054
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boeniger, Mark F.
AU - Lummus, Zana L.
AU - Biagini, Raymond E.
AU - Bernstein, David I.
AU - Swanson, Mark C.
AU - Reed, Charles
AU - Massoudi, Mehran
T1 - Exposure to Protein Aeroallergens in Egg Processing Facilities.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/06//
VL - 16
IS - 6
M3 - Article
SP - 660
EP - 670
SN - 1047322X
AB - Proteinaceous materials in the air can be highly allergenic and result in a range of immunologically mediated respiratory effects, including asthma. We report on the largest evaluation of exposure to date of airborne egg protein concentrations in an egg breaking and processing plant that had cases of occupational asthma. Personal air samples for egg protein were analyzed in duplicate on each PTFE filter using two analytical methods: (1) a commercial assay for non-specific total protein, and (2) indirect competitive inhibition assay using an ELISA method to quantify specific egg protein components. The highest concentrations were found in the egg washing room (mean exposure 644 μg/m[sup 3]) and breaking room (255 μg/m[sup 3]), which were also the areas where the risk of being sensitized was the greatest. There was excellent quantitative agreement between the airborne concentrations of total protein and sum of the specific protein antigens (ovalbumin, ovomucoid, and lysozyme). The correlation coefficient of the log-transformed data from the two methods was 0.88 (p < 0.0001). Size-selective sampling also indicated that most of the aerosol was capable of reaching the small airways. The methods described can be utilized to evaluate employee exposure to egg proteins. Exposure documentation, coupled with recommended exposure reduction strategies, could facilitate prevention of future employee sensitization and allergic respiratory responses by identifying high-exposure jobs and evaluating control measures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - EGG products industry
KW - DISEASES
KW - ASTHMA
KW - EMPLOYEES
KW - Allergy
KW - Occupational asthma
KW - Occupational exposure
KW - Protein
KW - Sensitization
N1 - Accession Number: 4485612; Boeniger, Mark F. 1 Lummus, Zana L. 2 Biagini, Raymond E. 1 Bernstein, David I. 2 Swanson, Mark C. 3 Reed, Charles 3 Massoudi, Mehran 4; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: University of Cincinnati Allergy Lab, Cincinnati, Ohio 3: Mayo Clinic, Rochester,Minnesota 4: Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Jun2001, Vol. 16 Issue 6, p660; Subject Term: ALLERGENS; Subject Term: EGG products industry; Subject Term: DISEASES; Subject Term: ASTHMA; Subject Term: EMPLOYEES; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Occupational asthma; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: Protein; Author-Supplied Keyword: Sensitization; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/104732201750175861
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tucker, Samuel P.
AU - Reynolds, John M.
AU - Wickman, Don C.
AU - Hines, Cynthia J.
AU - Perkins, James B.
T1 - Development of Sampling and Analytical Methods for Concerted Determination of Commonly Used Chloroacetanilide, Chlorotriazine, and 2,4-D Herbicides in Hand-Wash, Dermal-Patch, and Air Samples.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2001/06//
VL - 16
IS - 6
M3 - Article
SP - 698
EP - 707
SN - 1047322X
AB - Sampling and analytical methods were developed for commonly used chloroacetanilide, chlorotriazine, and 2,4- D herbicides in hand washes, on dermal patches, and in air. Eight herbicides selected for study were alachlor, atrazine, cyanazine, 2,4-dichlorophenoxyacetic acid (2,4-D), metolachlor, simazine, and two esters of 2,4-D, the 2-butoxyethyl ester (2,4-D, BE) and the 2-ethylhexyl ester (2,4-D, EH). The hand-wash method consisted of shaking the worker'shand in 150 mL of isopropanol in a polyethylene bag for 30 seconds. The dermal-patch method entailed attaching a 10-cm × 10-cm × 0.6-cm polyurethane foam (PUF) patch to the worker for exposure; recovery of the herbicides was achieved by extraction with 40 mL of isopropanol. The air method involved sampling with an OVS-2 tube (which contained an 11-mm quartz fiber filter and two beds of XAD-2 resin) and recovery with 2 mL of 10:90 methanol:methyl t-butyl ether. Analysis of each of the three sample types was performed by gas chromatography with an electron-capture detector. Diazomethane in solution was employed to convert 2,4-D as the free acid to the methyl ester in each of the three methods for ease of gas chromatography. Silicic acid was added to sample solutions to quench excess diazomethane. Limits of detection for all eight herbicides were matrix-dependent and, generally, less than 1 microgram per sample for each matrix. Sampling and analytical methods met NIOSH evaluation criteria for all herbicides in hand-wash samples, for seven herbicides in air samples (all herbicides except cyanazine), and for six herbicides in dermal-patch samples (all herbicides except cyanazine and 2,4-D). Speciation of 2,4-D esters and simultaneous determination of 2,4-D acid were possible without losses of the esters or of other herbicides (acetanilides and triazines) being determined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBICIDES
KW - ACETANILIDE
KW - TRIAZINES
KW - DICHLOROPHENOXYACETIC acid
KW - EMPLOYEES
KW - HEALTH
KW - 24D ACID
KW - 24D ESTERS
KW - AIR SAMPLES
KW - Chloroacetanilides
KW - Chlorotriazines
KW - DERMAL PATCHES
KW - GAS CHROMATOGRAPHY
KW - HAND WASHES
KW - Herbicides
N1 - Accession Number: 4485619; Tucker, Samuel P. 1 Reynolds, John M. 2 Wickman, Don C. 2 Hines, Cynthia J. 1 Perkins, James B. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: DataChem Laboratories, Inc., Salt Lake City, Utah; Source Info: Jun2001, Vol. 16 Issue 6, p698; Subject Term: HERBICIDES; Subject Term: ACETANILIDE; Subject Term: TRIAZINES; Subject Term: DICHLOROPHENOXYACETIC acid; Subject Term: EMPLOYEES; Subject Term: HEALTH; Author-Supplied Keyword: 24D ACID; Author-Supplied Keyword: 24D ESTERS; Author-Supplied Keyword: AIR SAMPLES; Author-Supplied Keyword: Chloroacetanilides; Author-Supplied Keyword: Chlorotriazines; Author-Supplied Keyword: DERMAL PATCHES; Author-Supplied Keyword: GAS CHROMATOGRAPHY; Author-Supplied Keyword: HAND WASHES; Author-Supplied Keyword: Herbicides; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/104732201750175942
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bauchner, Howard
AU - Simpson, Lisa
AU - Chessare, John
T1 - Changing physician behaviour.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2001/06//
VL - 84
IS - 6
M3 - Article
SP - 459
EP - 462
SN - 00039888
AB - The article discusses about the importance of improving the quality of health care in Great Britain. The health development hopes to influence physician behaviour and affect how physicians make decisions on behalf of patients. The paper briefly reviews issues related to quality of care to set a context for the need to change physician decision making as a key step to improvements in quality. It also presents a contemporary view of how physicians make decisions. It summarises what is known about changing physician behaviour. The focus is on ambulatory care rather than inpatient services.
KW - PHYSICIANS (General practice)
KW - MEDICAL care -- Quality control
KW - DECISION making
KW - OUTPATIENT medical care
KW - PUBLIC health
KW - ATTITUDES
KW - GREAT Britain
N1 - Accession Number: 12949241; Bauchner, Howard 1; Email Address: hbauchne@ahrq.gov Simpson, Lisa 2 Chessare, John 3; Affiliation: 1: Professor, Pediatrics and Public Health, Boston University School of Medicine, Child and Adolescent Health Scholar-in-Residence, Agency for Healthcare Research and Quality, 6010 Executive Blvd, Suite 201, Rockville, MD 20852, USA. 2: Deputy Director, Agency for Healthcare Research and Quality. 3: Professor of Pediatrics, Boston University School of Medicine Chief Medical Officer, Boston Medical Center.; Source Info: Jun2001, Vol. 84 Issue 6, p459; Subject Term: PHYSICIANS (General practice); Subject Term: MEDICAL care -- Quality control; Subject Term: DECISION making; Subject Term: OUTPATIENT medical care; Subject Term: PUBLIC health; Subject Term: ATTITUDES; Subject Term: GREAT Britain; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clements, C.
AU - Ball, L.K.
AU - Ball, R.
AU - Pratt, R.
T1 - Thiomersal in Vaccines: Is Removal Warranted?
JO - Drug Safety
JF - Drug Safety
Y1 - 2001/06//
VL - 24
IS - 8
M3 - Article
SP - 567
EP - 574
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - The mercury-based vaccine preservative thiomersal has come under scrutiny in recent months because of its presence in certain vaccines that provide the foundation of childhood immunisation schedules. Over the past decade new vaccines have been added to the recommended childhood schedule, and the relatively smaller bodyweight of infants has led to concern that the cumulative exposure of mercury from infant vaccines may exceed certain guidelines for the human consumption of mercury. In the US, government agencies and professional societies have recently recommended that thiomersal be removed altogether from vaccines. Some involved in developing vaccine policy feel that the evidence to support these safety concerns has not risen to the level required for such a response. This apparent divergence of opinion has left healthcare professionals and the public with uncertainty about the potential health effects from low level exposure to thiomersal as well as the necessity of removing thiomersal from vaccines. At present, scientific investigation has not found conclusive evidence of harm from thiomersal in vaccines. As a precautionary measure, efforts are under way to remove or replace thiomersal from vaccines and providers should anticipate the availability of more vaccine products that are thiomersal-free over the coming years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - MERCURY
KW - PRESERVATION of materials
KW - THERAPEUTIC use
KW - Children
KW - Thiomersal, adverse reactions
KW - Vaccines, adverse reactions
N1 - Accession Number: 4731272; Clements, C. 1 Ball, L.K. 2 Ball, R. 2 Pratt, R. 2; Affiliation: 1: Department of Vaccines and Biologicals, World Health Organization, Geneva, Switzerland 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jun2001, Vol. 24 Issue 8, p567; Subject Term: VACCINES; Subject Term: MERCURY; Subject Term: PRESERVATION of materials; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Children; Author-Supplied Keyword: Thiomersal, adverse reactions; Author-Supplied Keyword: Vaccines, adverse reactions; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eisenberg, John M.
T1 - Putting Research to Work: Reporting and Enhancing the Impact of Health Services Research.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/06//
VL - 36
IS - 2
M3 - Article
SP - x
EP - xviii
PB - Wiley-Blackwell
SN - 00179124
AB - This article presents information on reporting and enhancing the impact of health services research, published in June 2001 issue of the journal "Health Services Research." Health services researchers, particularly those who are stewards of the public purse, must keep in mind that the ultimate purpose of the work is to improve health care and, as a result, improve the health of the public. One of the ways research helps to achieve that goal, as well as improve access to care and to more affordable care, is to demonstrate what works in improving quality, outcomes, costs and access.
KW - MEDICAL care
KW - PUBLIC health
KW - MEDICAL care -- Research
KW - RISK assessment
KW - MEDICAL care costs
KW - HEALTH Services Research (Periodical)
N1 - Accession Number: 12182205; Eisenberg, John M. 1; Affiliation: 1: Agency for Healthcare Research and Quality.; Source Info: Jun2001, Vol. 36 Issue 2, px; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: MEDICAL care -- Research; Subject Term: RISK assessment; Subject Term: MEDICAL care costs; Reviews & Products: HEALTH Services Research (Periodical); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyer, Joette M.
AU - Silliman, Nancy P.
AU - Dixon, Cheryl A.
AU - Siepman, Nancy Y.
AU - Sugg, Jennifer E.
AU - Hopkins, Robert J.
T1 - Helicobacter pylori and Early Duodenal Ulcer Status Post-Treatment: a Review.
JO - Helicobacter
JF - Helicobacter
Y1 - 2001/06//
VL - 6
IS - 2
M3 - Article
SP - 84
EP - 92
PB - Wiley-Blackwell
SN - 10834389
AB - Abstract Background. Data submitted to the FDA were reviewed to analyze the relationship between Helicobacter pylori infection and the incidence of early duodenal ulcers, within 6 weeks, following treatment. Materials and Methods. Retrospective analyzes were performed on data from three H. pylori development programs submitted to the FDA: ranitidine-bismuth-citrate (RBC), lansoprazole (L) and omeprazole (O). Efficacy assessments for the RBC, L and O programs were made at end of a 4-week treatment period, 4–6 weeks following the end of a 14-day treatment period, and 4 weeks following the end of a 4-week treatment period, respectively. Results. Overall, there was a 15%, 21% and 23% decrease in the number of patients in the RBC, L and O programs, respectively, with ulcers among H. pylori cleared/eradicated patients post-treatment compared with patients with persistent infection. Among patients who did not have cleared/eradicated H. pylori in the RBC and O programs, where antisecretory agents were continued beyond the antimicrobial treatment period, the number of ulcers was lower in the antisecretory plus antimicrobial subgroups compared with the antimicrobial alone subgroups (37% vs. 46% for RBC and 33% vs. 42% for O). Among patients with cleared/eradicated H. pylori, the number of patients with ulcers in the antimicrobial alone subgroups and antisecretory plus antimicrobial subgroups were similar within each program. Antimicrobials alone had significantly lower rates of ulcers among patients with cleared/eradicated H. pylori as compared with patients without clearance/eradication. Conclusions. The early incidence of duodenal ulcers is significantly decreased in patients with H. pylori clearance/eradication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Helicobacter is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HELICOBACTER pylori infections
KW - OMEPRAZOLE
KW - ANTI-infective agents
KW - ULCERS
KW - clinical trials
KW - eradication
KW - lansoprazole
KW - omeprazole
KW - ranitidine-bismuth-citrate
KW - Ulcers
N1 - Accession Number: 4616885; Meyer, Joette M. 1 Silliman, Nancy P. 1 Dixon, Cheryl A. 1 Siepman, Nancy Y. 2 Sugg, Jennifer E. 3 Hopkins, Robert J. 1; Affiliation: 1: Food and Drug Administration, Division of Special Pathogen and Immunologic Drug Products, Rockville, MD; 2: TAP Pharmaceutical Products Inc., Lake Forest, IL; and 3: AstraZeneca L.P., Wayne, PA, USA; Source Info: Jun2001, Vol. 6 Issue 2, p84; Subject Term: HELICOBACTER pylori infections; Subject Term: OMEPRAZOLE; Subject Term: ANTI-infective agents; Subject Term: ULCERS; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: eradication; Author-Supplied Keyword: lansoprazole; Author-Supplied Keyword: omeprazole; Author-Supplied Keyword: ranitidine-bismuth-citrate; Author-Supplied Keyword: Ulcers; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1523-5378.2001.00013.x
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DB - aph
ER -
TY - JOUR
AU - Umehara, H
AU - Umehara, Hisanori
AU - Goda, Seiji
AU - Imai, Toshio
AU - Nagano, Yutaka
AU - Minami, Yasuhiro
AU - Tanaka, Yoshiya
AU - Okazaki, Toshiro
AU - Bloom, Eda T
AU - Domae, Naochika
T1 - Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.
JO - Immunology & Cell Biology
JF - Immunology & Cell Biology
Y1 - 2001/06//
VL - 79
IS - 3
M3 - Article
SP - 298
EP - 302
PB - Nature Publishing Group
SN - 08189641
AB - Summary A newly identified CX3C-chemokine, fractalkine, expressed on activated endothelial cells plays an important role in leucocyte adhesion and migration. Co-immobilized fractalkine with fibronectin or intercellular adhesion molecule-1 enhanced adhesion of THP-1 cells, which express the fractalkine receptor (CX3CR1), compared with that observed for each alone. That adherence was fractalkine-dependent and was confirmed in blocking studies. However, soluble fractalkine induced little chemotaxis in THP-1 cells in comparison to monocyte chemotactic protein-1 (MCP-1), which induced a strong chemotactic response. Moreover, the membrane form of fractalkine expressed on ECV304 cells reduced MCP-1 mediated chemotaxis of THP-1 cells. These results indicate that fractalkine may function as an adhesion molecule between monocytes and endothelial cells rather than as a chemotactic factor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology & Cell Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMOKINES
KW - CELL adhesion molecules
KW - CHEMOTAXIS
KW - INTEGRINS
KW - CELL lines
KW - cell adhesion
KW - endothelial cells
KW - fractalkine
KW - integrin
KW - THP-1 cells
N1 - Accession Number: 4564692; Umehara, H Umehara, Hisanori 1 Goda, Seiji 1 Imai, Toshio 2 Nagano, Yutaka 1 Minami, Yasuhiro 3 Tanaka, Yoshiya 4 Okazaki, Toshiro 5 Bloom, Eda T 6 Domae, Naochika 1; Affiliation: 1: Department of Internal Medicine, Osaka Dental University, Osaka, 2: Kan Research Institute, Kyoto, 3: Department of Biomedical Regulation and Parasitology, Kobe University School of Medicine, Kobe, 4: First Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyushu, 5: Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan and 6: The Division of Cellular and Gene Therapies (HFM-518), Center for Biologics Evaluation Research, Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Jun2001, Vol. 79 Issue 3, p298; Subject Term: CHEMOKINES; Subject Term: CELL adhesion molecules; Subject Term: CHEMOTAXIS; Subject Term: INTEGRINS; Subject Term: CELL lines; Author-Supplied Keyword: cell adhesion; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: fractalkine; Author-Supplied Keyword: integrin; Author-Supplied Keyword: THP-1 cells; Number of Pages: 5p; Document Type: Article
L3 - 10.1046/j.1440-1711.2001.01004.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berg, Cynthia J.
AU - Wilcox, Lynne S.
AU - Philip J. d'Almada, Lynne S.
T1 - The Prevalence of Socioeconomic and Behavioral Characteristics and their Impact on Very Low Birth Weight in Black and White Infants in Georgia.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2001/06//
VL - 5
IS - 2
M3 - Article
SP - 75
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives: We examined possible reasons for the disparity in the rate of very low birth weight (VLBW) delivery (<1500 g) in the United States between black women and white women. Methods: Using data from a population-based, case–control study of very low birth weight infants, we compared the prevalence of sociodemographic and behavioral characteristics between black and white mothers of normal birth weight infants; the difference in these characteristics between case and control mothers; and, using logistic regression, calculated odds ratios for VLBW for black versus white infants, adjusting for these characteristics. Results: Although black women were disadvantaged on every variable examined, they did not report more behavioral risk factors. Among white women, several traditional risk factors were associated with VLBW, while among black women, only marital status, cigarette smoking, and vitamin nonuse were associated with VLBW delivery. Controlling for the socioeconomic and behavioral factors reduced the odds ratio for VLBW delivery among black mothers from 3.7 to 3.3. Conclusions: Racial disparity in socioeconomic status may be greater than our current ability to adjust for it in epidemiologic studies. The fact that traditional risk factors were not associated with VLBW delivery in black women may be due to the very high prevalence of these risk factors among black women or to different or additional risks or stresses experienced by black women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW birth weight
KW - BLACK women
KW - WHITE women
KW - WOMEN -- United States
KW - UNITED States
KW - Georgia
KW - infant
KW - low birth weight
KW - poverty
KW - race
KW - socioeconomic status
N1 - Accession Number: 11307862; Berg, Cynthia J. 1; Email Address: cjb3@cdc.gov Wilcox, Lynne S. 1 Philip J. d'Almada, Lynne S. 2; Affiliation: 1: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, U.S. Public Health Service, U.S., Department of Health and Human Services, Atlanta, Georgia 2: Battelle Memorial Institute, 505 King Avenue, Columbus, Ohio 43201; Source Info: Jun2001, Vol. 5 Issue 2, p75; Subject Term: LOW birth weight; Subject Term: BLACK women; Subject Term: WHITE women; Subject Term: WOMEN -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Georgia; Author-Supplied Keyword: infant; Author-Supplied Keyword: low birth weight; Author-Supplied Keyword: poverty; Author-Supplied Keyword: race; Author-Supplied Keyword: socioeconomic status; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cuellar, Alison Evans
AU - Libby, Anne M.
AU - Snowden, Lonnie R.
T1 - How Capitated Mental Health Care Affects Utilization by Youth in the Juvenile Justice and Child Welfare Systems.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2001/06//
VL - 3
IS - 2
M3 - Article
SP - 61
EP - 72
SN - 15223434
AB - Examine the impact of Colorado's Medicaid mental health carve-out program on children in child welfare and juvenile justice systems. Medicaid claims and encounter data for two experimental managed care sites and one comparison fee-for-service site are used to estimate a two-part model of inpatient, outpatient, and residential treatment center utilization, controlling for patient characteristics. The study finds that juvenile justice and child welfare populations were more strongly affected by managed care than the general youth population, regarding reduced utilization of inpatient and outpatient services. Increases in Residential Treatment Centers use were greater for juvenile justice than either the child welfare sample or the total sample. Youth in child welfare increase utilization of outpatient services. Most utilization effects are stronger for not-for-profit than for-profit managed care organizations. The experience of Colorado implies that a mental health carve-out affects patterns of care for youth and differentially so for youth in juvenile justice and child welfare systems. Controlling for population characteristics, the effects are stronger for not-for-profit than for-profit managed care organizations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health services
KW - MENTAL health policy
KW - JUVENILE justice administration
KW - SOCIAL work with children
KW - MANAGED care plans (Medical care)
KW - YOUTH -- Health
KW - COLORADO
KW - capitation
KW - child welfare
KW - for-profit
KW - juvenile justice
KW - managed care
KW - Medicaid
KW - mental health services
KW - not-for-profit
KW - youth
N1 - Accession Number: 50189261; Cuellar, Alison Evans 1; Email Address: acuellar@pobox.com Libby, Anne M. 2 Snowden, Lonnie R. 1; Affiliation: 1: Center for Mental Health Services Research, University of California, Berkeley 94720 2: Kempe Children's Center, University of Colorado Health Sciences Center, Denver 80218; Source Info: Jun2001, Vol. 3 Issue 2, p61; Subject Term: MENTAL health services; Subject Term: MENTAL health policy; Subject Term: JUVENILE justice administration; Subject Term: SOCIAL work with children; Subject Term: MANAGED care plans (Medical care); Subject Term: YOUTH -- Health; Subject Term: COLORADO; Author-Supplied Keyword: capitation; Author-Supplied Keyword: child welfare; Author-Supplied Keyword: for-profit; Author-Supplied Keyword: juvenile justice; Author-Supplied Keyword: managed care; Author-Supplied Keyword: Medicaid; Author-Supplied Keyword: mental health services; Author-Supplied Keyword: not-for-profit; Author-Supplied Keyword: youth; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 12p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1023/A:1011507117644
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jensen, E
AU - Egan, S K
AU - Canady, R A
AU - Bolger, P M
T1 - Dietary exposures to persistent organic pollutants.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 157
EP - 162
PB - Sage Publications, Ltd.
SN - 07482337
AB - As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Applied Nutrition (CFSAN) is primarily interested in POPs as humans may be exposed to these compounds through food. Examples of POPs found in food include dioxins, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers, and some pesticide chemicals. This overview discusses various sources of data that CFSAN has used to estimate dietary exposure to POPs, and provides an example of a recent calculation of an estimate for dietary exposure for consumers in the USA to dioxins in the food supply. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Toxicology
KW - PERSISTENT pollutants
KW - RISK assessment
KW - Dietary exposure assessment
KW - Persistent organic pollutants
N1 - Accession Number: 8974017; Jensen, E 1 Egan, S K 1 Canady, R A 1 Bolger, P M 1; Affiliation: 1: US Food and Drug Administration, HFS-355, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA; Source Info: 2001, Vol. 17 Issue 5-10, p157; Subject Term: FOOD -- Toxicology; Subject Term: PERSISTENT pollutants; Subject Term: RISK assessment; Author-Supplied Keyword: Dietary exposure assessment; Author-Supplied Keyword: Persistent organic pollutants; Number of Pages: 6p; Document Type: Article
L3 - 10.1191/0748233701th104oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carrington, Clark D
AU - Bolger, P Michael
T1 - Methods for projecting long-term dietary exposure from short-term survey data for environmental contaminants.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 176
EP - 179
PB - Sage Publications, Ltd.
SN - 07482337
AB - Public health risk assessments often involve dietary exposures over long periods of time. However, most information about dietary consumption habits comes from short-term surveys that are conducted for periods of three days or less. When employed for characterizing long-term exposures, short-term surveys are likely to underestimate the number of persons consuming a particular food, while overestimating the amount consumed by each individual. Direct application of short-term data is particularly misleading for foods that are consumed infrequently. If a more accurate population estimate for chronic dietary intake is needed for a risk assessment, then two general techniques may be considered. The first method is simpler, while the second is more accurate. Both methods require information about the size of the population consuming the food over the long-term period. The simpler fractional adjustment method reduces consumption across the entire distribution by the ratio of consumer population sizes. Since this method will tend to underestimate high-end exposures and overestimate low-end exposures, it is most useful as a quick bounding exercise. Since short-term surveys are better at characterizing the behavior of frequent consumers, a second method employs an exponential function to reduce the low end of the population distribution by a greater amount than the high end. If available, additional information may be used to select the parameter values for the exponential adjustment. Otherwise, an uncertainty range may be used for the parameter values. Since the frequency-based method is more complex, it is most valuable when used as part of a chronic exposure simulation. Examples of both methods are given for the estimation of chronic wine consumption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Toxicology
KW - POLLUTANTS
KW - HEALTH risk assessment
KW - PUBLIC health
KW - CHRONIC DIETARY ASSESSMENT
N1 - Accession Number: 8974015; Carrington, Clark D 1 Bolger, P Michael 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Source Info: 2001, Vol. 17 Issue 5-10, p176; Subject Term: FOOD -- Toxicology; Subject Term: POLLUTANTS; Subject Term: HEALTH risk assessment; Subject Term: PUBLIC health; Author-Supplied Keyword: CHRONIC DIETARY ASSESSMENT; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
L3 - 10.1191/0748233701th109oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wallingford, Kenneth M
AU - Snyder, Erin M
T1 - Occupational exposures during the World Trade Center disaster response.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2001/06//
VL - 17
IS - 5-10
M3 - Article
SP - 247
EP - 253
PB - Sage Publications, Ltd.
SN - 07482337
AB - Upon the request of the New York City Department of Health, the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health (NIOSH) monitored occupational exposures among emergency response workers during the rescue and recovery activities at the World Trade Center disaster site from September 18 through 4 October 2001. During this period, over 1200 bulk and air samples were collected to estimate or characterize workers' occupational exposures. Samples were collected and analyzed for asbestos, carbon monoxide (CO), chlorodifluoromethane (Freon[sup ®] 22), diesel exhaust, hydrogen sulfide, inorganic acids, mercury and other metals, polynuclear aromatic hydrocarbons, respirable particulate not otherwise regulated (PNOR), respirable crystalline silica, total PNOR, and volatile organic compounds. Exposures to most of these potential hazards did not exceed NIOSH Recommended Exposure Limits or Occupational Safety and Health Administration Permissible Exposure Limits. However, one torch cutter was overexposed to cadmium and another worker (and possibly three others) was overexposed to CO. The elevated cadmium and CO levels were the result of workers using oxy-acetylene cutting torches and gasoline-powered cutting saws. Recommendations were made to ensure adequate ventilation and worker understanding when using these tools and, where possible, to substitute rechargeable, battery-powered cutting saws for gasoline-powered ones. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASBESTOS
KW - CADMIUM
KW - CARBON monoxide
KW - INDUSTRIAL toxicology
KW - SEPTEMBER 11 Terrorist Attacks, 2001
KW - Asbestos
KW - Carbon monoxide
KW - Occupational exposure
KW - World Trade Center
N1 - Accession Number: 8974029; Wallingford, Kenneth M 1 Snyder, Erin M 1; Affiliation: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-11), Cincinnati, Ohio 45226, USA; Source Info: 2001, Vol. 17 Issue 5-10, p247; Subject Term: ASBESTOS; Subject Term: CADMIUM; Subject Term: CARBON monoxide; Subject Term: INDUSTRIAL toxicology; Subject Term: SEPTEMBER 11 Terrorist Attacks, 2001; Author-Supplied Keyword: Asbestos; Author-Supplied Keyword: Carbon monoxide; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: World Trade Center; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1191/0748233701th112oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baine, William B.
AU - Yu, William
AU - Summe, James P.
T1 - Epidemiologic Trends in the Hospitalization of Elderly Medicare Patients for Pneumonia, 1991-1998.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/07//
VL - 91
IS - 7
M3 - Article
SP - 1121
EP - 1123
PB - American Public Health Association
SN - 00900036
AB - Conclusions. An epidemic of hospitalization for aspiration pneumonia smoldered over 8 years. Significant disparities existed in hospitalization risks by race, sex, and principal diagnosis. (Am J Public Health. 2001 ;91:1121-1123) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care for the aged
KW - HOSPITAL care
KW - MEDICARE
KW - PNEUMONIA
KW - UNITED States
N1 - Accession Number: 4724916; Baine, William B. 1; Email Address: wbaine@ahrq.gov Yu, William 2 Summe, James P. 2; Affiliation: 1: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockvile, Md. 2: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Md.; Source Info: Jul2001, Vol. 91 Issue 7, p1121; Subject Term: MEDICAL care for the aged; Subject Term: HOSPITAL care; Subject Term: MEDICARE; Subject Term: PNEUMONIA; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2730
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tucker, Geoffrey T.
AU - Houston, J. Brian
AU - Huang, Shiew-Mei
T1 - Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus.
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
Y1 - 2001/07//
VL - 52
IS - 1
M3 - Article
SP - 107
EP - 117
PB - Wiley-Blackwell
SN - 03065251
AB - Summarizes the outcomes of a drug development conference held in Basel, Switzerland in November 2000 which attempted to develop a consensus on the conduct of in vitro and in vivo studies of metabolic and transport interactions. Complexities and standardization of in vitro studies; Priorities for transporter research; In vitro predictive model; Regulatory requirements for the evaluation of drug-drug interactions.
KW - DRUG development
KW - DRUG metabolism
KW - CONFERENCES & conventions
KW - SWITZERLAND
KW - BASEL (Switzerland)
N1 - Accession Number: 4821212; Tucker, Geoffrey T. 1 Houston, J. Brian 2 Huang, Shiew-Mei 3; Affiliation: 1: Molecular Pharmacology & Pharmacogenetics, Division of Clinical Sciences, University of Sheffield, The Royal Hallamshire Hospital, Sheffield S10 2JF, 2: School of Pharmacy & Pharmaceutical Sciences, University of Manchester, Manchester M13 9 PL, UK, 3: Office of Clinical Pharmacology & Biopharmaceutics (OCPB), Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA; Source Info: Jul2001, Vol. 52 Issue 1, p107; Subject Term: DRUG development; Subject Term: DRUG metabolism; Subject Term: CONFERENCES & conventions; Subject Term: SWITZERLAND; Subject Term: BASEL (Switzerland); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article; Full Text Word Count: 6805
L3 - 10.1046/j.0306-5251.2001.Temp.1441.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Matheson, J. M.
AU - Lange, R. W.
AU - Lemus, R.
AU - Karol, M. H.
AU - Luster, M. I.
T1 - Importance of inflammatory and immune components in a mouse model of airway reactivity to toluene diisocyanate (TDI).
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2001/07//
VL - 31
IS - 7
M3 - Article
SP - 1067
EP - 1076
PB - Wiley-Blackwell
SN - 09547894
AB - Background Nearly 9 million individuals are exposed to agents in the workplace associated with asthma, and isocyanates represent the most common cause of occupationally induced asthma. Objectives Nonetheless, the immunological mechanisms responsible for isocyanate-induced asthma are not clear. A murine model for toluene diisocyanate (TDI) asthma is described and employed to examine inflammatory and immune components that may be involved in the disease. Methods Groups (n = 6) of C57BL/6J and athymic mice were sensitized by subcutaneous injection (20 µl on day 1, 5 µl on days 4 and 11), and 7 days later challenged by inhalation (100 p.p.b., days 20, 22 and 24) with TDI. Twenty-four hours following the last challenge the tracheae and lungs were examined for histological changes as well as for the expression of Th1, Th2 and pro-inflammatory cytokines. Mice were also examined for airway reactivity to methacholine challenge and for specific and total IgE and IgG antibodies. Results TDI sensitization resulted in increased reactivity to methacholine challenge as well as a significant inflammatory response in the trachea and nares of wild-type mice, but not in the athymic mice nor in the lungs of the C57BL/6J mice. Airway inflammation was characterized by inflammatory cell influx, goblet cell metaplasia and epithelial damage. Histological changes in the trachea were accompanied by increased mRNA expression of interleukin (IL)-4, tumour necrosis factor α, lymphotoxin β, lymphotactin and Rantes, as well as TDI-specific IgG antibodies and elevated levels of total IgE. IgE-specific antibodies were not detected with this exposure regimen but were produced when the TDI concentrations were increased. Conclusions These studies provide a unique murine model for occupational asthma that generates both inflammatory and immune mediators similar to those occurring in TDI-induced asthma in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOCYANATES
KW - ASTHMA
KW - RESPIRATORY allergy
KW - ALLERGY
KW - Airway hypersensitivity
KW - occupational asthma
KW - Toluene diisocyanate
N1 - Accession Number: 4821243; Matheson, J. M. 1 Lange, R. W. 2 Lemus, R. 3 Karol, M. H. 3 Luster, M. I. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 2: Pathology and Toxicology, 3M Pharmaceuticals, St Paul, Minnesota, 3: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Source Info: Jul2001, Vol. 31 Issue 7, p1067; Subject Term: ISOCYANATES; Subject Term: ASTHMA; Subject Term: RESPIRATORY allergy; Subject Term: ALLERGY; Author-Supplied Keyword: Airway hypersensitivity; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: Toluene diisocyanate; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1046/j.1365-2222.2001.01125.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Encinosa, William
T1 - A comment on Neudeck and Podczeck's "adverse selection and regulation in health insurance markets".
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2001/07//
VL - 20
IS - 4
M3 - Article
SP - 667
EP - 673
SN - 01676296
AB - Using the Grossman equilibrium concept, Neudeck and Podczeck [Journal of Health Economics 15 (1996) 387] show that imposing a minimum standard on a perfectly competitive insurance market can result in anti-competitive effects: decreased welfare with some insurers earning positive profits. However, the Grossman concept precludes an insurer from offering two separating, cross-subsidizing health plans. When an insurer can offer multiple plans (as under both the Nash and Miyazaki-Wilson equilibrium concepts), I show that minimum standards result in a doubleton equilibrium, never allow positive total profits, and increase welfare. This is of interest since in 1997 more than half of establishments in the U.S. offering choice of multiple plans did so through a single insurer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - EQUILIBRIUM (Economics)
KW - DELEGATED legislation
KW - WELFARE economics
KW - PROFIT
KW - UNITED States
KW - Adverse selection
KW - Health insurance minimum standards
KW - Regulation
N1 - Accession Number: 11948060; Encinosa, William 1; Email Address: wencinos@ahrq.gov; Affiliation: 1: Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Suite 605, 2101 E. Jefferson St., Rockville, MD 20852, USA.; Source Info: Jul2001, Vol. 20 Issue 4, p667; Subject Term: HEALTH insurance; Subject Term: EQUILIBRIUM (Economics); Subject Term: DELEGATED legislation; Subject Term: WELFARE economics; Subject Term: PROFIT; Subject Term: UNITED States; Author-Supplied Keyword: Adverse selection; Author-Supplied Keyword: Health insurance minimum standards; Author-Supplied Keyword: Regulation; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crespo, Carlos J.
AU - Smit, Ellen
AU - Carter-Pokras, Olivia
AU - Andersen, Ross
T1 - Acculturation and Leisure-Time Physical Inactivity in Mexican American Adults: Results From NHANES III, 1988-1994.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/08//
VL - 91
IS - 8
M3 - Article
SP - 1254
EP - 1257
PB - American Public Health Association
SN - 00900036
AB - Conclusions. Acculturation seems to be positively associated with participation in leisure-time physical activity. (Am J Public Health. 2001;91:1254-1257) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACCULTURATION
KW - LEISURE
KW - HYPOKINESIA
KW - MEXICAN Americans
KW - NATIONAL health services
KW - PUBLIC health
KW - HEALTH surveys -- United States
KW - UNITED States
N1 - Accession Number: 4905216; Crespo, Carlos J. 1; Email Address: ccrespo@buffalo.edu Smit, Ellen Carter-Pokras, Olivia 2 Andersen, Ross 3; Affiliation: 1: School of Medicine and Biomedical Sciences, State University of New York, Buffalo 2: Office of Minority Health, US Department of Health and Human Services, Washington, DC 3: School of Medicine, Johns Hopkins University, Baltimore; Source Info: Aug2001, Vol. 91 Issue 8, p1254; Subject Term: ACCULTURATION; Subject Term: LEISURE; Subject Term: HYPOKINESIA; Subject Term: MEXICAN Americans; Subject Term: NATIONAL health services; Subject Term: PUBLIC health; Subject Term: HEALTH surveys -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 2418
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, M-L.
AU - Lesko, L.
AU - Williams, R.L.
T1 - Measures of Exposure versus Measures of Rate and Extent of Absorption.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2001/08//
VL - 40
IS - 8
M3 - Article
SP - 565
EP - 572
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Regulatory assessment of bioavailability and bioequivalence in the US frequently relies on measures of rate and extent of absorption. Rate of absorption is not only difficult to measure but also bears little clinical relevance. This paper proposes that measures of bioavailability and bioequivalence for drugs that achieve their therapeutic effects after entry into the systemic circulation are best expressed in terms of early [partial area under the concentration-time curve (AUC)], peak plasma or serum drug concentration and total AUC exposure for a plasma or serum concentration-time profile. With suitable documentation, these systemic exposure measures can be related to efficacy and tolerability outcomes. The early measure is recommended for an immediate release drug product where a better control of drug absorption is needed, for example to ensure rapid onset of a therapeutic effect or to avoid an adverse reaction from a fast input rate. The 3 systemic exposure measures for bioavailability and bioequivalence studies can provide critical links between product quality and clinical outcome and thereby reduce the current emphasis on rate of absorption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOAVAILABILITY
KW - DRUGS -- Therapeutic equivalency
KW - UNITED States
KW - Bioavailability
KW - Bioequivalence
N1 - Accession Number: 4917677; Chen, M-L. 1 Lesko, L. 2 Williams, R.L. 3; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 2: Office of Clinical Pharmacology and Biopharmaceutics, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 3: The United States Pharmacopeia, Rockville, Maryland, USA; Source Info: 2001, Vol. 40 Issue 8, p565; Subject Term: BIOAVAILABILITY; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: UNITED States; Author-Supplied Keyword: Bioavailability; Author-Supplied Keyword: Bioequivalence; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenheck, Robert
AU - Morrissey, Joseph
AU - Lam, Julie
AU - Calloway, Michael
AU - Stolar, Marilyn
AU - Johnsen, Matthew
AU - Randolph, Frances
AU - Blasinsky, Margaret
AU - Goldman, Howard
AU - Rosenheck, R
AU - Morrissey, J
AU - Lam, J
AU - Calloway, M
AU - Stolar, M
AU - Johnsen, M
AU - Randolph, F
AU - Blasinsky, M
AU - Goldman, H
T1 - Service delivery and community: social capital, service systems integration, and outcomes among homeless persons with severe mental illness.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/08//
VL - 36
IS - 4
M3 - journal article
SP - 691
EP - 710
PB - Wiley-Blackwell
SN - 00179124
AB - Objectives: This study evaluated the influence of features of community social environment and service system integration on service use, housing, and clinical outcomes among homeless people with serious mental illness.Study Setting: A one-year observational outcome study was conducted of homeless people with serious mental illness at 18 sites.Data Sources: Measures of community social environment (e.g., social capital) were based on local surveys and voting records. Housing affordability was assessed with housing survey data. Service system integration was assessed through interviews with key informants at each site to document interorganizational transactions. Standardized clinical measures were used to assess clinical and housing outcomes in face-to-face interviews.Research Design: Structural equation modeling was used to determine the relationship between (1) characteristics of the social environment (social capital, housing affordability); (2) the level of integration of the service system for persons who are homeless in each community; (3) access to and use of services by individual clients; and (4) successful exit from homelessness or clinical improvement.Principal Findings: Social capital was associated with greater service systems integration, which was associated in turn with greater access to assistance from a public housing agency and to a greater probability of exiting from homelessness at 12 months. Housing affordability also predicted exit from homelessness. Neither environmental factors nor systems integration predicted outcomes for psychiatric problems, substance abuse, employment, physical health, or income support.Conclusion: Community social capital and service system integration are related through a series of direct and indirect pathways with better housing outcomes but not with superior clinical outcomes for homeless people with mental illness. Implications for designing improved service systems are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY health services
KW - HOMELESS persons
KW - MENTAL illness
KW - LIFESTYLES
KW - SOCIAL capital (Sociology)
KW - PUBLIC housing
KW - Homelessness
KW - housing
KW - mental health
KW - social capital
N1 - Accession Number: 12807092; Rosenheck, Robert 1,2 Morrissey, Joseph 3 Lam, Julie Calloway, Michael 4 Stolar, Marilyn 5 Johnsen, Matthew 6 Randolph, Frances 7 Blasinsky, Margaret 8 Goldman, Howard 9 Rosenheck, R 10 Morrissey, J Lam, J Calloway, M Stolar, M Johnsen, M Randolph, F Blasinsky, M Goldman, H; Affiliation: 1: Director, Northeast Program Evaluation Center, Department of Veterans Affairs, 950 Campbell Avenue, West Haven, CT 06516. 2: Professor of Psychiatry and Pubic Health, Yale School of Medicine, Joseph Morrissey. 3: Professor of Social Medicine and Psychiatry and Deputy Director, Sheps Center for Health Services Research, University of North Carolina, Chapel Hill. 4: Research Assistant Professor, Department of Psychiatry, School of Pharmacy, University- of North Carolina at Chapel Hill. 5: Biostatistician, Northeast Program Evaluation Center, Department of Veterans Affairs in West Haven, CT. 6: University of Massachusetts School of Medicine, Worcester, MA. 7: Acting Chief, Homeless Programs Brach, Center for Mental Health Services, SAMHSA U. S. Department of Health and Human Services. 8: Vice President of LOGICON/ROW Sciences, Inc., Rockville, MD. 9: Professor of Psychiatry and Co-Director, Center for Mental Health Services Research, University of Maryland school of Medicine, Baltimore. 10: Northeast Program Evaluation Center of the Department of Veterans Affairs, West Haven, CT 06516, USA; Source Info: Aug2001, Vol. 36 Issue 4, p691; Subject Term: COMMUNITY health services; Subject Term: HOMELESS persons; Subject Term: MENTAL illness; Subject Term: LIFESTYLES; Subject Term: SOCIAL capital (Sociology); Subject Term: PUBLIC housing; Author-Supplied Keyword: Homelessness; Author-Supplied Keyword: housing; Author-Supplied Keyword: mental health; Author-Supplied Keyword: social capital; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 531112 Lessors of social housing projects; Number of Pages: 20p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fisher, William H.
AU - Barreira, Paul J.
AU - Lincoln, Alisa K.
AU - Simon, Lorna J.
AU - White, Andrew W.
AU - Roy-Bujnowski, Kristen
AU - Sudders, Marylou
AU - Fisher, W H
AU - Barreira, P J
AU - Lincoln, A K
AU - Simon, L J
AU - White, A W
AU - Roy-Bujnowski, K
AU - Sudders, M
T1 - Insurance status and length of stay for involuntarily hospitalized patients.
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
Y1 - 2001/08//
VL - 28
IS - 3
M3 - journal article
SP - 334
EP - 346
PB - Springer Science & Business Media B.V.
SN - 10943412
AB - General and private psychiatric hospitals are becoming increasingly common as sites for involuntary hospitalization. Unlike the public facilities that these settings are supplanting, these hospitals must pay strict attention to issues associated with reimbursement, insurance status, and managed care. This article examines the effects of insurance status on length of stay for involuntarily hospitalized patients in general and private hospitals in Massachusetts. Using a two-stage sampling procedure, data on episodes of involuntary hospitalization were gathered and assessed using multiple regression. The primary effect was found between patients with Medicare, who had the longest stays, and individuals who were uninsured, who had the shortest. The data raise concerns that warrant closer scrutiny on the part of administrators and clinicians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Behavioral Health Services & Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LENGTH of stay in hospitals
KW - HEALTH insurance
KW - MENTAL health services
KW - MASSACHUSETTS
KW - UNITED States
N1 - Accession Number: 4981703; Fisher, William H. Barreira, Paul J. Lincoln, Alisa K. Simon, Lorna J. White, Andrew W. Roy-Bujnowski, Kristen Sudders, Marylou Fisher, W H 1 Barreira, P J Lincoln, A K Simon, L J White, A W Roy-Bujnowski, K Sudders, M; Affiliation: 1: Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA; Source Info: Aug2001, Vol. 28 Issue 3, p334; Subject Term: LENGTH of stay in hospitals; Subject Term: HEALTH insurance; Subject Term: MENTAL health services; Subject Term: MASSACHUSETTS; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 13p; Illustrations: 1 Graph; Document Type: journal article; Full Text Word Count: 6813
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stewart
AU - Reineke
AU - Ulaszek
AU - Fu
AU - Tortorello
T1 - Growth of Escherichia coli O157:H7 during sprouting of alfalfa seeds.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2001/08//
VL - 33
IS - 2
M3 - Article
SP - 95
EP - 99
PB - Wiley-Blackwell
SN - 02668254
AB - Aims: Escherichia coli O157:H7 was monitored daily during sprouting of alfalfa seeds inoculated at high (3·92 log10 cfu g–1) and low (1·86 log10 cfu g–1) levels to assess the extent of pathogen growth during production. Methods and Results: Sprouts and rinse water were tested by direct and membrane filter plating on modified sorbitol MacConkey agar and BCM O157:H7(+) agar; the antibody-direct epifluorescent filter technique; and rapid immunoassays. The pathogen reached maximum populations after one and two days of sprouting seeds inoculated at high and low levels, respectively; in either case, populations of 5–6 log10 cfu g–1 were reached. Detection limits of two rapid immunoassays, Reveal and VIP, without enrichment were determined to be 5–7 log10 cfu ml–1. Conclusions: These results show the ability of E. coli O157:H7 to grow to high levels during sprouting; however, because these levels may be below detection limits, it is necessary to include enrichment when monitoring sprout production for E. coli O157:H7 by the rapid test kits. Significance and Impact of the Study: The data indicate that sprouts may harbor high levels of pathogens. The appropriate use of rapid test methods for pathogen monitoring during sprouting is indicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Letters in Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - SPROUTS
KW - ALFALFA -- Seeds
KW - UNITED States
N1 - Accession Number: 6526766; Stewart 1 Reineke 2 Ulaszek 2 Fu 1 Tortorello 1; Affiliation: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA 2: Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, IL 60501, USA; Source Info: Aug2001, Vol. 33 Issue 2, p95; Subject Term: ESCHERICHIA coli; Subject Term: SPROUTS; Subject Term: ALFALFA -- Seeds; Subject Term: UNITED States; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 111940 Hay Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1046/j.1472-765X.2001.00957.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bloom, Eda T.
T1 - Commentaries.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2001/08//
VL - 8
IS - 3
M3 - Article
SP - 153
EP - 156
PB - Wiley-Blackwell
SN - 0908665X
AB - Focuses on various documents and reports about xenotransplantation. `Availability for Public Disclosure and Submission to FDA for Public Disclosure of Certain Data and Information Related to Human Gene Therapy or Xenotransplantation'; `Draft Guidance for Industry: Source Animal, Product, Preclinical, and Clinical Issues Concerning the Use of Xenotransplantation Products in Humans.'
KW - XENOGRAFTS
KW - GENE therapy
N1 - Accession Number: 4840306; Bloom, Eda T. 1; Affiliation: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, Division of Cellular and Gene Therapies, FDA/CBER/DCGT/LCI (HFM-518), Bldg. 29B/Room 2NN04, 8800 Rockville Pike, Bethesda, MD 20892, USA (E-mail: bloom@cber.fda.gov); Source Info: Aug2001, Vol. 8 Issue 3, p153; Subject Term: XENOGRAFTS; Subject Term: GENE therapy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, V.P.
T1 - Progress in Methodologies for Evaluating Bioequivalence of Topical Formulations.
JO - American Journal of Clinical Dermatology
JF - American Journal of Clinical Dermatology
Y1 - 2001/09//Sep/Oct2001
VL - 2
IS - 5
M3 - Article
SP - 275
EP - 280
PB - Springer Science & Business Media B.V.
SN - 11750561
AB - Assessment of bioequivalence of topical dermatological formulations is a challenge. Currently, comparative clinical studies are used to establish bioequivalence for most formulations (except corticosteroids). This article reviews different in vivo methodologies for determining bioequivalence, and the progress made in this area. Dermatopharmacokinetics is the term used to describe the pharmacokinetics of topically applied drugs in the stratum corneum. A tape stripping procedure used in dermatopharmacokinetic methodology measures the drug concentration in stratum corneum at the site of application. Various studies have shown dermatopharmacokinetics to be a reliable and reproducible method for determining bioequivalence, and have indicated that it is applicable for all topical dermatological drug products. However, confidence in this methodology needs to be established, particularly regarding its relevance to clinical drug efficacy. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Dermatology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Therapeutic equivalency
KW - DERMATOPHARMACOLOGY
KW - SKIN -- Physiology
KW - Bioequivalence
KW - Topical
N1 - Accession Number: 5343882; Shah, V.P. 1; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Sep/Oct2001, Vol. 2 Issue 5, p275; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: DERMATOPHARMACOLOGY; Subject Term: SKIN -- Physiology; Author-Supplied Keyword: Bioequivalence; Author-Supplied Keyword: Topical; Number of Pages: 6p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ding, Linna
AU - Shevach, Ethan M.
T1 - Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen.
JO - Immunology
JF - Immunology
Y1 - 2001/09//
VL - 104
IS - 1
M3 - Article
SP - 28
EP - 36
PB - Wiley-Blackwell
SN - 00192805
AB - SummaryThymic shared antigen-1 (TSA-1) is a member of the Ly-6 family of glycosyl-phosphatidylinositol (GPI)-linked proteins. While it has been proposed that TSA-1 may play a role in thymic development, a physiological ligand for this antigen has not been identified. Here we report that a monoclonal antibody (mAb) to TSA-1, generated by immunizing a hamster with CD40 ligand (CD40L)-activated B cells, interferes with the function of FcγRIIB on splenic B cells and the B-cell lymphoma cell line, M12, by binding to TSA on the same cells. The interaction of anti-TSA with FcγRIIB resulted in an inhibition of the ability of the FcγRIIB to cross-link and/or aggregate soluble anti-CD3 or soluble anti-Cβ T-cell receptor (TCR), leading to an inhibition of induction of expression of CD25 and CD69, interleukin (IL)-2 production and proliferation of naive T cells. Cross-blocking studies with mAbs strongly suggested that a physical association exists between TSA-1 and the FcγRIIB on the surface of activated B cells and favour the view that a functional intermolecular association exists between these two distinct membrane antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - FC receptors
KW - IMMUNE complexes
KW - B cells
N1 - Accession Number: 5212914; Ding, Linna 1 Shevach, Ethan M. 2; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, and 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: Sep2001, Vol. 104 Issue 1, p28; Subject Term: MONOCLONAL antibodies; Subject Term: FC receptors; Subject Term: IMMUNE complexes; Subject Term: B cells; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2567.2001.01275.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nakano, M.
AU - Kodama, Y.
AU - Ohtaki, K.
AU - Itoh, M.
AU - Delongchamp, R.
AU - Awa, A. A.
AU - Nakamura, N.
T1 - Detection of stable chromosome aberrations by FISH in A-bomb survivors: comparison with previous solid Giemsa staining data on the same 230 individuals.
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
Y1 - 2001/09//
VL - 77
IS - 9
M3 - Article
SP - 971
EP - 977
PB - Taylor & Francis Ltd
SN - 09553002
AB - Purpose: To evaluate the relative abilities of the solid Giemsa staining (conventional) and fluorescence in situ hybridization (FISH) methods in the detection of stable chromosome aberrations in the peripheral blood lymphocytes of A-bomb survivors. Materials and methods: Lymphocytes from a total of 230 A-bomb survivors for whom prior chromosome aberration data had been obtained by the conventional method were recently examined afresh using FISH in which chromosomes 1, 2 and 4 were painted with composite probes. Results: It was found that the early use of the solid Giemsa staining method had allowed the detection of translocations with a mean frequency of 73% of the value for the genome-equivalent translocation frequency (F[sub G] ) that was now obtained using FISH. The disparity may at least in part be due to the reciprocal exchange of seemingly identical amount of chromosome material; such exchanges can escape detection by the conventional method but can be readily identified using FISH. Conclusion: It has previously been established that the conventional method can detect about 20% of radiation-induced translocations as abnormal monocentric chromosomes. Present results indicate that an additional 50% can be detected if proper karyotyping is conducted and the remaining 30% are not likely to be detected unless FISH or banding methods are used. Thus, solid Giemsa staining accompanied by karyotyping may not be quite as unsuitable as is generally assumed for retrospective biodosimetry analyses, which deal mainly with stable aberrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Radiation Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAINS & staining (Microscopy)
KW - CHROMOSOMES
KW - LYMPHOCYTES
KW - RADIATION
N1 - Accession Number: 5254363; Nakano, M. 1 Kodama, Y. 1 Ohtaki, K. 1 Itoh, M. 1 Delongchamp, R. 2 Awa, A. A. 1 Nakamura, N. 1; Affiliation: 1: Department of Genetics and Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima 732-0815, Japan 2: Department of Statistics and Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima 732-0815, Japan and Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Sep2001, Vol. 77 Issue 9, p971; Subject Term: STAINS & staining (Microscopy); Subject Term: CHROMOSOMES; Subject Term: LYMPHOCYTES; Subject Term: RADIATION; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/09553000110050065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turner, Barbara J.
AU - Fleishman, John A.
AU - Wenger, Neil
AU - London, Andrew S.
AU - Burnam, M. Audrey
AU - Shapiro, Martin F.
AU - Bing, Eric G.
AU - Stein, Michael D.
AU - Longshore, Douglas
AU - Bozzette, Samuel A.
AU - Turner, B J
AU - Fleishman, J A
AU - Wenger, N
AU - London, A S
AU - Burnam, M A
AU - Shapiro, M F
AU - Bing, E G
AU - Stein, M D
AU - Longshore, D
AU - Bozzette, S A
T1 - Effects of drug abuse and mental disorders on use and type of antiretroviral therapy in HIV-infected persons.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2001/09//
VL - 16
IS - 9
M3 - journal article
SP - 625
EP - 633
SN - 08848734
AB - Objective: To distinguish the effects of drug abuse, mental disorders, and problem drinking on antiretroviral therapy (ART) and highly active ART (HAART) use.Design: Prospective population-based probability sample of 2,267 (representing 213,308) HIV-infected persons in care in the United States in early 1996.Measurements: Self-reported ART from first (January 1997-July 1997) to second (August 1997-January 1998) follow-up interviews. Drug abuse/dependence, severity of abuse, alcohol use, and probable mental disorders assessed in the first follow-up interview. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) estimated from weighted models for 1) receipt of any ART, and 2) receipt of HAART among those on ART.Results: Of our study population, ART was reported by 90% and HAART by 61%. Over one third had a probable mental disorder and nearly half had abused any drugs, but drug dependence (9%) or severe abuse (10%) was infrequent. Any ART was less likely for persons with dysthymia (AOR, 0.74; CI, 0.58 to 0.95) but only before adjustment for drug abuse. After full adjustment with mental health and drug abuse variables, any ART was less likely for drug dependence (AOR, 0.58; CI, 0.34 to 0.97), severe drug abuse (AOR, 0.52; CI, 0.32 to 0.87), and HIV risk from injection drug use (AOR, 0.55; CI, 0.39 to 0.79). Among drug users on ART, only mental health treatment was associated with HAART (AOR, 1.57; CI, 1.11 to 2.08).Conclusions: Drug abuse-related factors were greater barriers to ART use in this national sample than mental disorders but once on ART, these factors were unrelated to type of therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - MENTAL illness
KW - HIV-positive persons -- Medical care
KW - anti-HIV agents
KW - HIV infections
KW - mental disorders
KW - substance abuse, intravenous drug abuse
KW - substance-related disorders
N1 - Accession Number: 5528152; Turner, Barbara J. 1 Fleishman, John A. 1 Wenger, Neil 1 London, Andrew S. 1 Burnam, M. Audrey 1 Shapiro, Martin F. 1 Bing, Eric G. 1 Stein, Michael D. 1 Longshore, Douglas 1 Bozzette, Samuel A. 1 Turner, B J 2 Fleishman, J A Wenger, N London, A S Burnam, M A Shapiro, M F Bing, E G Stein, M D Longshore, D Bozzette, S A; Affiliation: 1: From the Division of General Internal Medicine, Department of Medicine, University of Pennsylvania (BJT), Philadelphia, Pa; the Agency for Healthcare Research and Quality (JAF), Rockville, Md; the University of California at Los Angeles (NW, MFS), Los Angeles, Calif; the RAND Health Program (MAB, SAB, DL, MFS), Santa Monica, Calif; the University of California–San Diego, and the Veterans Affairs San Diego Health System (SAB), San Diego, Calif; Center for AIDS Research, Education, and Services and Collaborative Alcohol Research Center, Charles R. Drew University of Medicine and Science (EGB), Los Angeles, Calif; the Department of Sociology, Kent State University (ASL), Kent, Ohio; and the Division of General Internal Medicine, Rhode Island Hospital (MDS), Providence, RI. 2: Division of General Internal Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pa 19104, USA; Source Info: Sep2001, Vol. 16 Issue 9, p625; Subject Term: DRUG abuse; Subject Term: MENTAL illness; Subject Term: HIV-positive persons -- Medical care; Author-Supplied Keyword: anti-HIV agents; Author-Supplied Keyword: HIV infections; Author-Supplied Keyword: mental disorders; Author-Supplied Keyword: substance abuse, intravenous drug abuse; Author-Supplied Keyword: substance-related disorders; Number of Pages: 9p; Document Type: journal article
L3 - 10.1046/j.1525-1497.2001.016009625.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walrath, Christine
AU - dosReis, Susan
AU - Miech, Richard
AU - Liao, Qinghong
AU - Holden, Wayne
AU - de Carolis, Gary
AU - Santiago, Rolando
AU - Leaf, Philip
T1 - Referral Source Differences in Functional Impairment Levels for Children Served in the Comprehensive Community Mental Health Services for Children and Their Families Program.
JO - Journal of Child & Family Studies
JF - Journal of Child & Family Studies
Y1 - 2001/09//
VL - 10
IS - 3
M3 - Article
SP - 385
EP - 397
PB - Springer Science & Business Media B.V.
SN - 10621024
AB - We report one of the first multi-site investigations into referral source variation in functional impairment for children with serious emotional disturbance served in systems of care settings. Baseline data collected as part of the national evaluation for the Comprehensive Community Mental Health Services for Children and Their Families Program was used to assess the comparability of functional status for children referred from traditional mental health versus non-mental health agencies. Results indicate that children referred from child welfare and family groups have significantly lower levels of overall dysfunction than those referred from mental health, while children referred from school and juvenile justice agencies have comparable levels. Clinical and research implications are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Child & Family Studies is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEVELOPMENTALLY disabled children
KW - CHILD development deviations
KW - CHILD mental health services
KW - MEDICAL care
KW - COMMUNITY mental health services
KW - PATHOLOGICAL psychology
KW - children's mental health services
KW - functioning
KW - Random-effects model
KW - random-effects model.
KW - referral source
KW - system of care
N1 - Accession Number: 5909610; Walrath, Christine 1; Email Address: cwalrath@jhpsh.edu dosReis, Susan 2 Miech, Richard 3 Liao, Qinghong 3 Holden, Wayne 4 de Carolis, Gary 5 Santiago, Rolando 6 Leaf, Philip 7; Affiliation: 1: Research Associate, Department of Mental Hygiene, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 2: Post Doctoral Fellow, Department of Mental Hygiene, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 3: Assistant Professor, Department of Mental Hygiene, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 4: Senior Analyst, ORC Macro, Atlanta, GA. 5: Chief, Child, Adolescent and Family Branch of Center for Mental Health Services, Rockville, MD. 6: Program Director for Evaluation, Child, Adolescent and Family Branch of Center for Mental Health Services, Rockville, MD. 7: Professor, Department of Mental Hygiene, Johns Hopkins School of Public Health, Baltimore, MD.; Source Info: Sep2001, Vol. 10 Issue 3, p385; Subject Term: DEVELOPMENTALLY disabled children; Subject Term: CHILD development deviations; Subject Term: CHILD mental health services; Subject Term: MEDICAL care; Subject Term: COMMUNITY mental health services; Subject Term: PATHOLOGICAL psychology; Author-Supplied Keyword: children's mental health services; Author-Supplied Keyword: functioning; Author-Supplied Keyword: Random-effects model; Author-Supplied Keyword: random-effects model.; Author-Supplied Keyword: referral source; Author-Supplied Keyword: system of care; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shearer, Steven
AU - Toedt, Michael
T1 - Family Physicians' Observations of Their Practice, Well Being, and Health Care in the United States.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2001/09//
VL - 50
IS - 9
M3 - Article
SP - 751
EP - 756
PB - Frontline Medical Communications
SN - 00943509
AB - OBJECTIVE: Our goal was to characterize how family physicians perceive recent changes in the health care system and how content they are with various factors. STUDY DESIGN: We performed a cross-sectional mailed survey. POPULATION: The survey was completed by a random sample of 361 family physicians practicing in the United States. OUTCOMES MEASURED: The survey evaluated attitudes about corporate managed care, health care reform, career satisfaction, compensation, personal life satisfaction, workload stress, personal well-being, and residency training. RESULTS: Relative to survey data gathered in 1996, fewer family physicians in our survey reported that they were satisfied with their careers (59% vs 82%); fewer were satisfied with their compensation (55% vs 65%); and fewer would again choose family practice as their specialty (66% vs 75%). Thirty-one percent worried that they were "burning out," as physicians, and 48% reported that they had experienced more stress-related symptoms in the past year. Only 7% agreed that corporate managed care is the best way to provide the health care America needs at a cost society can afford, but only 36% unequivocally endorsed the concept of a national health plan. Forty-two percent of the respondents reported that they had witnessed bad patient outcomes they perceived to be attributable to managed care business processes. CONCLUSIONS: The morale and career satisfaction of family physicians seems to have eroded in recent years, and discontent is common. As a group, family physicians are unhappy with the current health care system and quite unified about certain specific reforms, yet they are far from such consensus about more sweeping reform. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Family Practice is the property of Frontline Medical Communications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAMILY medicine
KW - PHYSICIANS (General practice)
KW - FAMILIES -- Health
KW - MEDICAL care
KW - JOB satisfaction
KW - ATTITUDE (Psychology)
KW - HEALTH care reform
KW - UNITED States
KW - attitudes about managed care [non-MESH]
KW - Career satisfaction [non-MESH]
KW - health care reform
KW - physician well being [non-MESH]
KW - physician well-being [non-MESH]
N1 - Accession Number: 5372399; Shearer, Steven 1; Email Address: steves@helix.org Toedt, Michael 2; Affiliation: 1: Department of Family Practice, Franklin Square Hospital Center, Baltimore, Maryland 2: United States Public Health Service, Cherokee, North Carolina; Source Info: Sep2001, Vol. 50 Issue 9, p751; Subject Term: FAMILY medicine; Subject Term: PHYSICIANS (General practice); Subject Term: FAMILIES -- Health; Subject Term: MEDICAL care; Subject Term: JOB satisfaction; Subject Term: ATTITUDE (Psychology); Subject Term: HEALTH care reform; Subject Term: UNITED States; Author-Supplied Keyword: attitudes about managed care [non-MESH]; Author-Supplied Keyword: Career satisfaction [non-MESH]; Author-Supplied Keyword: health care reform; Author-Supplied Keyword: physician well being [non-MESH]; Author-Supplied Keyword: physician well-being [non-MESH]; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Auger, A. P.
AU - Meredith, J. M.
AU - Snyder, G. L.
AU - Blaustein, J. D.
T1 - Oestradiol Increases Phosphorylation of a Dopamine- and Cyclic AMP-Regulated Phosphoprotein (DARPP-32) in Female Rat Brain.
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
Y1 - 2001/09//
VL - 13
IS - 9
M3 - Article
SP - 761
EP - 768
PB - Wiley-Blackwell
SN - 09538194
AB - AbstractRecent studies suggest that oestrogen and progestin receptors may be activated by the neurotransmitter dopamine, as well as by their respective ligands. Because intracerebroventricular infusion of D1, but not D2, dopaminergic receptor agonists increases oestrous behaviour in oestradiol-primed rats, we wanted to determine if treatment with oestradiol alters the activity of D1 receptor-associated processes in steroid receptor-containing areas in female rat brain. One D1 receptor-associated phosphoprotein that may be influenced by oestradiol is a dopamine- and cyclic AMP-regulated phosphoprotein, Mr = 32 000 (DARPP-32). Because DARPP-32 is phosphorylated in response to dopamine acting via a cAMP-dependent protein kinase, it provides a useful marker to examine where in the brain a particular stimulus might be altering the activity of D1 receptor-containing neurones. To determine if oestradiol alters the phosphorylation of DARPP-32, we stained immunocytochemically brain sections of female rats treated with behaviourally relevant doses of oestradiol or oil vehicle with an antibody that detects only the threonine 34-phosphorylated form of DARPP-32. Behaviourally effective doses of oestradiol increase the phosphorylation of DARPP-32 within the medial preoptic nucleus, bed nucleus of the stria terminalis, paraventricular nucleus of the hypothalamus and the ventromedial nucleus of the hypothalamus, 48 h after treatment. These data suggest that oestradiol increases the activity of D1 dopamine receptor-associated processes in oestrogen receptor-containing areas of female rat forebrain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neuroendocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTRADIOL
KW - NEURAL receptors
KW - brain.
KW - dopamine
KW - hypothalamus
KW - oestrogen
KW - steroids
N1 - Accession Number: 5251517; Auger, A. P. 1 Meredith, J. M. 2 Snyder, G. L. 3 Blaustein, J. D. 1; Affiliation: 1: Center for Neuroendocrine Studies, Neuroscience and Behavior Program, Tobin Hall, University of Massachusetts, Amherst, MA, USA. 2: Division of Neurotoxicology, National Center for Toxicological Research/USFDA, Jefferson, AR, USA. 3: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.; Source Info: Sep2001, Vol. 13 Issue 9, p761; Subject Term: ESTRADIOL; Subject Term: NEURAL receptors; Author-Supplied Keyword: brain.; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: hypothalamus; Author-Supplied Keyword: oestrogen; Author-Supplied Keyword: steroids; Number of Pages: 8p; Illustrations: 3 Black and White Photographs, 2 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2826.2001.00700.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stork, Elizabeth
AU - Scholle, Sarah
AU - Greeno, Catherine
AU - Copeland, Valire
AU - Kelleher, Kelly
T1 - Monitoring and Enforcing Cultural Competence in Medicaid Managed Behavioral Health Care.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2001/09//
VL - 3
IS - 3
M3 - Article
SP - 169
EP - 177
SN - 15223434
AB - In recent years cultural competence has expanded beyond language provisions to include understanding and factoring into services provision the cultural perspectives clients may have that are different from the majority culture. The federal government requires state Medicaid programs to offer culturally competent services, but little is known about how states implement such mandates and monitor and enforce them. We reviewed the origins and implications of cultural competence mandates and conducted a brief case study of 5 states to learn about the implementation of cultural competence provisions in behavioral managed care contracts. We found that states and managed behavioral health organizations (MBHOs) vary in their definitions and implementation of standards to ensure mental health care access for vulnerable populations. Although states had a variety of oversight mechanisms, varying contractual requirements ranging from optional to required, vague contract language, no existing standardized indicators or definitions, and scant data on the cultural characteristics of the populations enrolled in Medicaid managed care hamper monitoring and enforcement of cultural competence by states. Implications for MBHOs, states, and the federal government, as well as services researchers, follow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CULTURAL competence
KW - MEDICAID
KW - MEDICAL care
KW - HEALTH programs
KW - CASE studies
KW - cultural competence
KW - managed care contracts
KW - MBHOs
KW - Medicaid mental health care
KW - monitoring managed care
N1 - Accession Number: 50189271; Stork, Elizabeth 1; Email Address: emsst28@pitt.edu Scholle, Sarah 1,2 Greeno, Catherine 1 Copeland, Valire 1 Kelleher, Kelly 1,2; Affiliation: 1: Center for Mental Health Services Research, School of Social Work, University of Pittsburgh, Pittsburgh 2: Child Services Research and Development, Western Psychiatric Institute and Clinic, University of Pittsburgh Schools of Medicine and Public Health, Pittsburgh, Pennsylvania; Source Info: Sep2001, Vol. 3 Issue 3, p169; Subject Term: CULTURAL competence; Subject Term: MEDICAID; Subject Term: MEDICAL care; Subject Term: HEALTH programs; Subject Term: CASE studies; Author-Supplied Keyword: cultural competence; Author-Supplied Keyword: managed care contracts; Author-Supplied Keyword: MBHOs; Author-Supplied Keyword: Medicaid mental health care; Author-Supplied Keyword: monitoring managed care; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 9p; Document Type: Article
L3 - 10.1023/A:1011575632212
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schreiber, G.B.
AU - Sanchez, A.M.
AU - Garratty, G.
AU - Nass, C.C.
AU - Tu, Y.
AU - Busch, M.P.
AU - Williams, A.E.
T1 - Mammalian Brain Consumption by U.S. Blood Donors: Brains Today, Deferred Tomorrow?
JO - Transfusion
JF - Transfusion
Y1 - 2001/09/02/Sep2001 Supplement 1
VL - 41
M3 - Article
SP - 35S
EP - 35S
SN - 00411132
AB - Background: The theoretical concern that new variant CJD could be transmitted by eating an infected animal's brain raises the possibility of mammalian brain consumption becoming a deferral criterion. No information concerning the brain consumption habits of donors exists. Methods: Findings from a 1998 anonymous mail survey of 92,581 US blood donors from eight geographically diverse blood centers were assessed using weighted chi-square and descriptive analysis. Results: Approximately 52,650 donors (57%) responded to the survey. Mammalian brains were ever consumed by 6.4% of donors, with a 3.6 fold regional variability in brain eating among the blood centers (ranging from 3.8% to 13.7%). Types of brains donors reported consuming included: cow (3.6%), hog (1.7%), sheep (1.0%), squirrel (0.3%), goat (0.2%), monkey (0.1%) and rabbit (<0.1%). Brain eating was highest among older (age 55+, 11%), foreign born (17%), male (8%), Asian (14%) and Hispanic (12%) donors. Among Asians, Chinese donors were the most likely to consume brains (15% US born; 28% foreign born), and among Hispanics, Mexicans had the highest rates of brain consumption (11% US born; 33% foreign born). Most brain consumers ate only one type of brain (84%) and reported a lifetime consumption of <5 times (62%). However, 1.4% of brain consumers did report eating brains >100 times in their lives. Squirrel and goat brain eaters were the most likely to report a lifetime consumption of >100 times (3% for each group). Conclusions: If mammalian brain consumption became a deferral criterion, regional impacts on donor deferral could be considerable. With the relationship between bovine spongiform encephalopathy from contaminated human food and new-variant Creutzfeldt-Jacob disease any deferral would probably be based on consumption of cow or sheep brains, 4.3% of donors. Thus, it is possible that more donors would be lost from this restriction than from the deferrals associated with residence in the UK (an estimated 2.2%). [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD donors
KW - DISEASES
KW - CREUTZFELDT-Jakob disease
KW - TRANSMISSION
KW - UNITED States
N1 - Accession Number: 11257926; Schreiber, G.B. 1 Sanchez, A.M. 1 Garratty, G. 2 Nass, C.C. 3 Tu, Y. 1 Busch, M.P. 4 Williams, A.E. 5; Affiliation: 1: Westat, Rockville, MD 2: American Red Cross Blood Services, Los Angeles, CA 3: American Red Cross Blood Services, Baltimore, MD 4: Blood Centers of the Pacific, San Francisco, CA 5: U.S. Food and Drug Administration, Rockville, MD; for the NHLBI Retrovirus Epidemiology Donor Study (REDS); Source Info: Sep2001 Supplement 1, Vol. 41, p35S; Subject Term: BLOOD donors; Subject Term: DISEASES; Subject Term: CREUTZFELDT-Jakob disease; Subject Term: TRANSMISSION; Subject Term: UNITED States; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Syin, Chiang
AU - Parzy, Daniel
AU - Traincard, Francois
AU - Boccaccio, Irène
AU - Joshi, Manju B.
AU - Lin, David T.
AU - Yang, Xiao-Ming
AU - Assemat, Karine
AU - Doerig, Christian
AU - Langsley, Gordon
T1 - The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 2001/09/15/
VL - 268
IS - 18
M3 - Article
SP - 4842
EP - 4849
PB - Wiley-Blackwell
SN - 00142956
AB - In Plasmodium falciparum, the causative agent of human malaria, the catalytic subunit gene of cAMP-dependent protein kinase (Pfpka-c) exists as a single copy. Interestingly, its expression appears developmentally regulated, being at higher levels in the pathogenic asexualstages than in the sexual forms of parasite that areresponsible for transmission to the mosquito vector. Within asexual parasites, PfPKA activity can be readily detected in schizonts. Similar to endogenous PKA activityofnoninfected red blood cells, the parasite enzymecan be stimulated by cAMP and inhibited by protein kinase inhibitor.Importantly, exvivo treatment of infected erythrocytes with the classical PKA-C inhibitor H89 leads to a block in parasite growth. This suggests that the PKA activities of infected red blood cells are essential for parasite multiplication. Finally, structural considerations suggest that drugs targeting the parasite, rather than the erythrocyte enzyme, might be developed that could help in the fight against malaria. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMODIUM falciparum
KW - PROTEIN kinase C
KW - PARASITES
KW - MALARIA
KW - GENETICS
KW - CHEMICAL inhibitors
KW - TREATMENT
KW - H89
KW - inhibition
KW - parasite
KW - PKA
N1 - Accession Number: 6031746; Syin, Chiang 1 Parzy, Daniel 2 Traincard, Francois 3 Boccaccio, Irène 4 Joshi, Manju B. 1 Lin, David T. 1 Yang, Xiao-Ming 1 Assemat, Karine 5 Doerig, Christian 6 Langsley, Gordon 7; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; 2: Institut de Médecine Tropical du Service de Santé des Armées, Le Pharo, Marseille, France; 3: Unité de Régulation Enzymatique des Activités Cellulaires, FRE CNRS 2364, Département de Biologie Moléculaire, Institut Pasteur, Paris, France; 4: INSERM U399, Marseille, France; 5: Unité de Biochimie Structurale, Département d'Immunologie, Institut Pasteur, Paris, France; 6: INSERM U 511, La Pitié-Salpétrière, Paris, France; 7: Laboratoire de Signalization Immunoparasitaire, URA CNRS 1960, Département d'Immunologie, Institut Pasteur, Paris, France; Source Info: Sep2001, Vol. 268 Issue 18, p4842; Subject Term: PLASMODIUM falciparum; Subject Term: PROTEIN kinase C; Subject Term: PARASITES; Subject Term: MALARIA; Subject Term: GENETICS; Subject Term: CHEMICAL inhibitors; Subject Term: TREATMENT; Author-Supplied Keyword: H89; Author-Supplied Keyword: inhibition; Author-Supplied Keyword: parasite; Author-Supplied Keyword: PKA; Number of Pages: 8p; Illustrations: 5 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1046/j.1432-1327.2001.02403.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Milberg, John
AU - Sharma, Rupa
AU - Scott, Floretta
AU - Conviser, Richard
AU - Marconi, Katherine
AU - Parham, Deborah
T1 - Factors Associated with Delays in Accessing HIV Primary Care in Rural Arkansas.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2001/10//
VL - 15
IS - 10
M3 - Article
SP - 527
EP - 532
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - While debate continues at what stage of human immunodeficiency virus (HIV) disease to begin combination antiretroviral therapy, a number of clinical and public health benefits are linked to early entry into primary care soon after first testing HIV positive. However, HIV-infected patients continue to test late and delay entry into care. We used routinely collected demographic and clinical information to examine which factors are associated with delays in seeking care in a predominantly rural, economically poor area of Arkansas. The study population is 75% African American and male and 70% lack health insurance; nearly one fourth were referred from prison. At diagnosis, two thirds of the population had CD4 counts below 500 cells per microliter. Days from initial HIV diagnosis to entry into care declined from a median of 178 in 1994 to 24 in 1998. In 1998, 75% of the population entered into primary care within 2 months of diagnosis. However, CD4 counts at HIV diagnosis also declined in this period, from a median of 427 in 1995 to 208 cells per microliter in 1998. More recent year of diagnosis was associated with a shorter delay in seeking care; males, and individuals lacking health insurance took significantly longer to enter into care than females and those with insurance, respectively. Our univariate finding of extensive delays in seeking care in the prison population did not hold in the multivariate analysis. We found significant delays in time to initial HIV diagnosis, and further considerable delays in males and those lacking health insurance in the time taken to enter into primary care. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - HIV infections
KW - PRIMARY health care
KW - ARKANSAS
KW - UNITED States
N1 - Accession Number: 5523192; Milberg, John 1 Sharma, Rupa 2 Scott, Floretta 3 Conviser, Richard 1 Marconi, Katherine 1 Parham, Deborah 1; Affiliation: 1: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland 2: Arkansas Department of Health, Little Rock, Arkansas 3: Jefferson Comprehensive Care System, Inc., Pine Bluff, Arkansas; Source Info: Oct2001, Vol. 15 Issue 10, p527; Subject Term: HIV-positive persons -- Medical care; Subject Term: HIV infections; Subject Term: PRIMARY health care; Subject Term: ARKANSAS; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Article
L3 - 10.1089/108729101753205694
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Bunyavanich, Supinda
AU - Walkup, Ruth B.
T1 - US Public Health Leaders Shift Toward a New Paradigm of Global Health.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/10//
VL - 91
IS - 10
M3 - Editorial
SP - 1556
EP - 1558
PB - American Public Health Association
SN - 00900036
AB - The authors provides information on research which determined the theoretical and practical associations of international health leaders in government, nongovernmental, professional, multilateral and academic organizations. The research held discussions about the concepts fundamental to globalization of health and the difference between international and global health approaches. They also addressed ethical concerns about health disparities and national sovereignty from academics, the World Bank advisor, the Institute of Medicine advisor and health association representatives.
KW - WORLD health
KW - PUBLIC health research
KW - GLOBALIZATION
KW - HEALTH disparities
KW - MEDICAL ethics
KW - INSTITUTE of Medicine (U.S.)
N1 - Accession Number: 5270394; Bunyavanich, Supinda 1 Walkup, Ruth B. 1; Email Address: rwalkup@osophs.dhhs.gov; Affiliation: 1: Office of International and Refugee Health, US Department of Health and Human Services, Rockville, Md.; Source Info: Oct2001, Vol. 91 Issue 10, p1556; Subject Term: WORLD health; Subject Term: PUBLIC health research; Subject Term: GLOBALIZATION; Subject Term: HEALTH disparities; Subject Term: MEDICAL ethics; Company/Entity: INSTITUTE of Medicine (U.S.); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 2090
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, M-L.
AU - Lesko, L.J.
T1 - Individual Bioequivalence Revisited.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2001/10//
VL - 40
IS - 10
M3 - Article
SP - 701
EP - 706
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - For decades, the establishment of bioequivalence has generally relied on the comparison of population averages between the test and reference formulations. In the early 1990s, individual bioequivalence was proposed to ensure that an individual could be switched from the reference product to the test product with unchanged efficacy and safety. Since 1997, the US Food and Drug Administration (FDA) has published three guidance documents on the proposed criterion and statistical methodology for the individual bioequivalence approach. From a scientific stand-point, the individual bioequivalence criterion appears to offer several advantages for some drug products compared with the average criterion. It allows comparison of intraindividual variances, scaling the bioequivalence criterion to the reference variability and detection of an important subject-by-formulation interaction if it exists. Based on these considerations, the FDA has recently recommended replicate study designs for modified release dosage forms and highly variable drug products. The new criterion also promotes inclusion of a heterogeneous population of volunteers in bioequivalence studies. Despite all the advantages of the individual bioequivalence approach, questions remain on the optimal use of replicate study designs and the proposed criterion for evaluation of bioequivalence between formulations. In the finalised guidance documents, therefore, the FDA maintains the average bioequivalence criterion while allowing other criteria under certain circumstances. Collection and analysis of bioequivalence data from replicate study designs may permit further assessment and resolution of these questions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Therapeutic equivalency
KW - BIOPHARMACEUTICS
KW - Bioequivalence
N1 - Accession Number: 5315582; Chen, M-L. 1 Lesko, L.J. 2; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 2: Office of Clinical Pharmacology and Biopharmaceutics, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Oct2001, Vol. 40 Issue 10, p701; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Bioequivalence; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Case, Caroline
AU - Johantgen, Meg
AU - Steiner, Claudia
T1 - Outpatient Mastectomy: Clinical, Payer, and Geographic Influences.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/10//
VL - 36
IS - 5
M3 - Article
SP - 869
EP - 884
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To determine (1) the use of outpatient services for all surgical breast procedures for breast cancer and (2) the influence of payer and state on the use of outpatient services for complete mastectomy in light of state and federal length-of- stay managed care legislation. Data Sources. Healthcare Cost and Utilization Project representing all discharges from hospitals and ambulatory surgery centers for five states (Colorado, Connecticut, Maryland, New Jersey, and New York) and seven years (1990-96). Study Design. Longitudinal, cross-sectional analyses of all women undergoing inpatient and outpatient complete mastectomy (CMAS), subtotal mastectomy (STMAS), and lumpectomy (LUMP) for cancer were employed. Total age-adjusted rates and percentage of outpatient CMAS, STMAS, and LUMP were compared. Independent influence of state and HMO payer on likelihood of receiving an outpatient CMAS was determined from multivariate models, adjusting for clinical characteristics (age <50 years, comorbidity, metastases, simple mastectomy, breast reconstruction) and hospital characteristics (teaching, ownership, urban). Principal Findings. In 1993, 1 to 2 percent of CMASs were outpatient in all states. By 1996, 8 percent of CMASs were outpatient in Connecticut, 13 percent were outpatient in Maryland, and 22 percent were outpatient in Colorado. In comparison, LUMPs were 78 to 88 percent outpatient, and by 1996, 43 to 72 percent of STMASs were outpatient. In 1996, women were 30 percent more likely to receive an outpatient CMAS in New York, 2.5 times more likely in Connecticut, 4.7 times more likely in Maryland, and 8.6 times more likely in Colorado compared to New Jersey. In addition, women with Medicare, Medicaid, or private commercial insurance were less likely to receive an outpatient CMAS compared to women with an HMO payer. Conclusions. LUMP is an outpatient procedure, and STMAS is becoming primarily outpatient. CMAS, while still primarily inpatient, is increasingly outpatient in some states. Although clinical characteristics remain important, the state in which a woman receives care and whether she has an HMO payer are strong determinants of whether she receives an outpatient CMAS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTPATIENT services in hospitals
KW - OUTPATIENT medical care
KW - MASTECTOMY
KW - BREAST surgery
KW - FEMALE-to-male surgery
KW - MANAGED care plans (Medical care)
KW - Ambulatory surgery
KW - breast-conserving surgery
KW - managed care
KW - mastectomy
KW - practice pattern variation
N1 - Accession Number: 12807684; Case, Caroline 1 Johantgen, Meg 2 Steiner, Claudia 3; Affiliation: 1: Fellow, Primary Care Research, Department of Internal Medicine, Georgetown University, Washington, DC. 2: Assistant Professor, University of Maryland School of Nursing, Baltimore, MD. 3: Senior Research Physician, Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, 2101 East Jefferson, Suite 605, Rockville, MD 20852.; Source Info: Oct2001, Vol. 36 Issue 5, p869; Subject Term: OUTPATIENT services in hospitals; Subject Term: OUTPATIENT medical care; Subject Term: MASTECTOMY; Subject Term: BREAST surgery; Subject Term: FEMALE-to-male surgery; Subject Term: MANAGED care plans (Medical care); Author-Supplied Keyword: Ambulatory surgery; Author-Supplied Keyword: breast-conserving surgery; Author-Supplied Keyword: managed care; Author-Supplied Keyword: mastectomy; Author-Supplied Keyword: practice pattern variation; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621499 All other out-patient care centres; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horton, Arthur MacNeill
AU - Roberts, Charles
T1 - DEMOGRAPHIC EFFECTS ON THE TRAIL MAKING TEST IN NARCOTIC/OTHER OPIATE ABUSERS.
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
Y1 - 2001/10//
VL - 111
IS - 1/2
M3 - Article
SP - 101
PB - Taylor & Francis Ltd
SN - 00207454
AB - Examines narcotic and other opiate abusers on Trail Making Test (TMT), a test used to screen for cognitive impairments, in the U.S. Relation between educational level and TMT; Influence of sex, ethnicity and age on TMT.
KW - DRUG addicts
KW - PSYCHOLOGICAL tests
KW - UNITED States
KW - demographic effects
KW - narcotics
KW - substance abuse treatment
KW - trail making test
N1 - Accession Number: 6829775; Horton, Arthur MacNeill 1 Roberts, Charles 1; Affiliation: 1: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: 2001, Vol. 111 Issue 1/2, p101; Subject Term: DRUG addicts; Subject Term: PSYCHOLOGICAL tests; Subject Term: UNITED States; Author-Supplied Keyword: demographic effects; Author-Supplied Keyword: narcotics; Author-Supplied Keyword: substance abuse treatment; Author-Supplied Keyword: trail making test; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horton, Arthur McNeill
AU - Roberts, Charles
T1 - DERIVED TRAIL MAKING TEST INDICES IN A SAMPLE OF SUBSTANCE ABUSERS: DEMOGRAPHIC EFFECTS.
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
Y1 - 2001/10//
VL - 111
IS - 1/2
M3 - Article
SP - 123
PB - Taylor & Francis Ltd
SN - 00207454
AB - Examines derived indices on the Trail Making Test, a test often used to screen for cognitive impairments, in a sample of substance abusers in drug abuse treatment programs. Overview of TMT; Effect of demographic variables on derived indices.
KW - PSYCHOLOGICAL tests
KW - DRUG addicts
KW - derived indices
KW - drug abuse
KW - substance abuse treatment
KW - trail marking test
N1 - Accession Number: 6829977; Horton, Arthur McNeill 1 Roberts, Charles 1; Affiliation: 1: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: 2001, Vol. 111 Issue 1/2, p123; Subject Term: PSYCHOLOGICAL tests; Subject Term: DRUG addicts; Author-Supplied Keyword: derived indices; Author-Supplied Keyword: drug abuse; Author-Supplied Keyword: substance abuse treatment; Author-Supplied Keyword: trail marking test; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Overpeck, Md
AU - Brenner, Ra
AU - Cosgrove, C
AU - Trumble, Ac
AU - Kochanek, K
AU - MacDorman, M
T1 - Risk factors associated with national underascertainment of unexpected infant deaths.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2001/10//
VL - 15
IS - 4
M3 - Article
SP - A25
EP - A25
PB - Wiley-Blackwell
SN - 02695022
AB - Examines the risk factors associated with the underascertainment of abuse-related infant deaths in the United States. National estimates of unexpected infant deaths; Implication of unexpected infant deaths for the assignment of the cause of death; Efforts for prevention of infant abuse and unqualified causes of death.
KW - INFANT mortality
KW - PREVENTION of child abuse
KW - SUDDEN infant death syndrome
KW - UNITED States
N1 - Accession Number: 5396164; Overpeck, Md Brenner, Ra 1 Cosgrove, C 1 Trumble, Ac 1 Kochanek, K 1 MacDorman, M 1; Affiliation: 1: (Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA); Source Info: Oct2001, Vol. 15 Issue 4, pA25; Subject Term: INFANT mortality; Subject Term: PREVENTION of child abuse; Subject Term: SUDDEN infant death syndrome; Subject Term: UNITED States; Number of Pages: 1p; Document Type: Article
L3 - 10.1046/j.1365-3016.2001.00381-77.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Ch
AU - Overpeck, Md
AU - Kogan, Md
T1 - Black-white differences in health care utilization among children with frequent ear infections.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2001/10//
VL - 15
IS - 4
M3 - Article
SP - A25
EP - A26
PB - Wiley-Blackwell
SN - 02695022
AB - Examines the differences in the health care utilization between black and white children with frequent ear infections in the United States. Absence of difference on the prevalence of ear infection between white and black children; Delayed health care among black children; Percentage of ear surgeries between black and white children.
KW - MEDICAL care -- United States
KW - EAR -- Infections
KW - BLACK children
KW - WHITE children
KW - UNITED States
N1 - Accession Number: 5396162; Park, Ch Overpeck, Md 1 Kogan, Md 1; Affiliation: 1: (Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA); Source Info: Oct2001, Vol. 15 Issue 4, pA25; Subject Term: MEDICAL care -- United States; Subject Term: EAR -- Infections; Subject Term: BLACK children; Subject Term: WHITE children; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Article
L3 - 10.1046/j.1365-3016.2001.00381-79.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Stella M.
AU - Alexander, Greg R.
AU - Schwalberg, Renee
AU - Kogan, Michael D.
T1 - Prenatal Care Use Among Selected Asian American Groups.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/11//
VL - 91
IS - 11
M3 - Article
SP - 1865
EP - 1868
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study examined the predictors of 3 patterns of prenatal care use (no care, late initiation of care, and inadequate use after early initiation) for 4 Asian American ethnic groups in the United States. Methods. Single live births to US resident mothers of Chinese, Japanese, Korean, and Vietnamese ancestry (n = 273604) were selected from the 1992-1996 US natality files. Logistic regression was used to analyze the effects of maternal characteristics on the 3 use measures. Results. Korean Americans and Vietnamese Americans had the lowest levels of prenatal care use. Young or single motherhood, high parity for age, and low educational attainment were the main risk factors for low use. Conclusions. Considerable variability exists in prenatal care use among Asian American ethnic groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRENATAL care
KW - OBSTETRICS
KW - PRECONCEPTION care
KW - PRENATAL diagnosis
KW - PREVENTIVE health services
KW - LOGISTIC regression analysis
KW - IMMIGRANTS -- United States
KW - UNITED States
N1 - Accession Number: 5461040; Yu, Stella M. 1; Email Address: syu@hrsa.gov Alexander, Greg R. 2 Schwalberg, Renee 3 Kogan, Michael D. 1; Affiliation: 1: Maternal and Child Health Bureau, Office of Data and Information Management, Rockville, Md. 2: Department of Maternal and Child Health, School of Public Health, University of Alabama, Birmingham 3: Maternal and Child Health Information Resource Center, Washington, DC; Source Info: Nov2001, Vol. 91 Issue 11, p1865; Subject Term: PRENATAL care; Subject Term: OBSTETRICS; Subject Term: PRECONCEPTION care; Subject Term: PRENATAL diagnosis; Subject Term: PREVENTIVE health services; Subject Term: LOGISTIC regression analysis; Subject Term: IMMIGRANTS -- United States; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 3568
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scott, Walter Louis
AU - Collier, Paul
T1 - The Vessel Dilator for Central Venous Catheter Placement: Forerunner for Success or Vascular Misadventure?
JO - Journal of Intensive Care Medicine (Wiley-Blackwell)
JF - Journal of Intensive Care Medicine (Wiley-Blackwell)
Y1 - 2001/11//Nov/Dec2001
VL - 16
IS - 6
M3 - Article
SP - 263
EP - 269
SN - 08850666
AB - During placement of a central venous catheter (CVC), the vessel dilator and/or combination dilator/sheath-introducer are recognized as potential causative agents in numerous traumatic complications that may be erroneously ascribed to the catheter, placement needle, or guidewire. A review of the literature and device-user survey are offered in support of the need for additional training in safe dilator use, as well as the need to address device labeling and device design. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Intensive Care Medicine (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAVENOUS catheterization
KW - TRAUMATISM -- Complications
N1 - Accession Number: 5395871; Scott, Walter Louis 1 Collier, Paul 2; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Health and Industry Programs, Division of Device User Programs and Systems Analysis, Rockville, MD and 2: Department of Surgery and Medical Director, Noninvasive Vascular Laboratory, Sewickley Valley Hospital, Blackburn Rd., Sewickley, PA.; Source Info: Nov/Dec2001, Vol. 16 Issue 6, p263; Subject Term: INTRAVENOUS catheterization; Subject Term: TRAUMATISM -- Complications; Number of Pages: 7p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1046/j.1525-1489.2001.00263.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sen, Keya
AU - Asher, David M.
T1 - Multiplex PCR for detection of Enterobacteriaceae in blood.
JO - Transfusion
JF - Transfusion
Y1 - 2001/11//
VL - 41
IS - 11
M3 - Article
SP - 1356
EP - 1364
SN - 00411132
AB - Describes a multiplex polymerase chain reaction assay that can detect enterobacteriaceae in blood. Four types of bacterial species used in the study; Advantages of 16S rRNA gene to detect bacterial contamination; Potential of the assay to detect very small numbers of bacteria.
KW - POLYMERASE chain reaction
KW - ENTEROBACTERIACEAE
KW - BLOOD collection
N1 - Accession Number: 10918067; Sen, Keya 1 Asher, David M. 1; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: Nov2001, Vol. 41 Issue 11, p1356; Subject Term: POLYMERASE chain reaction; Subject Term: ENTEROBACTERIACEAE; Subject Term: BLOOD collection; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 3 Charts, 10 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thiriet, Nathalie
AU - Jouvert, Peggy
AU - Gobaille, Serge
AU - Solov'Eva, Olga
AU - Gough, Bobby
AU - Aunis, Dominique
AU - Ali, Syed
AU - Zwiller, Jean
T1 - C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain.
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
Y1 - 2001/11/15/
VL - 14
IS - 10
M3 - Article
SP - 1702
EP - 1708
PB - Wiley-Blackwell
SN - 0953816X
AB - Abstract The neuropeptide C-type natriuretic peptide (CNP) is the primary biologically active natriuretic peptide in brain. Using in situ hybridization, the present report demonstrates that CNP regulates egr-1, c-fos and junB immediate early gene expression in rat brain. In the frontal cortex, CNP induced immediate early gene expression whereas it inhibited dose-dependently the cocaine-induced early gene expression in the dopaminergic projection fields nucleus accumbens and caudate–putamen. CNP may produce its effect directly on dopaminergic neurons because we found that its receptor, guanylyl cyclase GC-B, was expressed in the mesencephalon where dopaminergic neurons originate, as well as in their projection fields. The inhibition by CNP of the early gene expression elicited by cocaine in the caudate–putamen is correlated with a CNP-evoked decrease in cocaine-induced rise in extracellular dopamine, measured by in vivo microdialysis experiments. The significance of the inhibition of cocaine-induced dopamine release and early gene induction by the endogenous peptide CNP is demonstrated by data indicating that CNP reduced the cocaine-induced spontaneous locomotor activation. By inhibiting dopaminergic neuronal activity, CNP represents a potential negative regulator of related behavioural effects of cocaine. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROPEPTIDES
KW - NATRIURESIS
KW - GENE expression
KW - c-fos
KW - egr-1
KW - Extracellular dopamine
KW - guanylyl cyclase
KW - junB
N1 - Accession Number: 5661646; Thiriet, Nathalie 1 Jouvert, Peggy 1 Gobaille, Serge 2 Solov'Eva, Olga 3 Gough, Bobby 4 Aunis, Dominique 1 Ali, Syed 4 Zwiller, Jean 1; Affiliation: 1: INSERM U338, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg, France 2: IFR 037, 5 rue Blaise Pascal, 67084 Strasbourg, France 3: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117871, Russia 4: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR72079, USA; Source Info: Nov2001, Vol. 14 Issue 10, p1702; Subject Term: NEUROPEPTIDES; Subject Term: NATRIURESIS; Subject Term: GENE expression; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: egr-1; Author-Supplied Keyword: Extracellular dopamine; Author-Supplied Keyword: guanylyl cyclase; Author-Supplied Keyword: junB; Number of Pages: 7p; Document Type: Article
L3 - 10.1046/j.0953-816X.2001.01791.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCormick, Marie C.
AU - Deal, Lisa W.
AU - Devaney, Barbara L.
AU - Chu, Dexter
AU - Moreno, Lorenzo
AU - Raykovich, Karen T.
T1 - The Impact on Clients of a Community-Based Infant Mortality Reduction Program: The National Healthy Start Program Survey of Postpartum Women.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2001/12//
VL - 91
IS - 12
M3 - Article
SP - 1975
EP - 1977
PB - American Public Health Association
SN - 00900036
AB - Objectives: This study assessed the effect of the national Healthy Start Program on its clients. Methods: We used a cross-sectional survey of a sample from Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) rosters of women less than 6 months postpartum who were residents of Healthy Start Program areas. Results: Healthy Start clients revealed higher sociodemographic risk, but not behavioral risk, for adverse pregnancy outcome than other area residents. They did not differ from other residents in receipt of services except for a greater likelihood of receiving case management, using birth control at the time of the interview, and rating their prenatal care more highly. Conclusions: The Healthy Start Program succeeded in enrolling women at high risk. It had little effect on the immediately concluded pregnancy, but it might influence future outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - HEALTH promotion
KW - INFANT mortality
KW - CHILD mortality
KW - BIRTH control
KW - MEDICAL care
N1 - Accession Number: 5582731; McCormick, Marie C. 1; Email Address: mmccormi@hsph.harvard.edu Deal, Lisa W. 1,2 Devaney, Barbara L. 3 Chu, Dexter 3 Moreno, Lorenzo 3 Raykovich, Karen T. 4; Affiliation: 1: Department of Maternal and Child Health, Harvard School of Public Health, Boston, Mass. 2: David and Lucile Packard Foundation, Los Altos, Calif. 3: Mathematica Policy Research Inc, Princeton, NJ 4: Office of Program Evaluation and Legislation, Health Resources and Services Administration, Rockville, Md.; Source Info: Dec2001, Vol. 91 Issue 12, p1975; Subject Term: PUBLIC health; Subject Term: HEALTH promotion; Subject Term: INFANT mortality; Subject Term: CHILD mortality; Subject Term: BIRTH control; Subject Term: MEDICAL care; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2682
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jason, J.
AU - Archibald, L. K.
AU - Nwanyanwu, O. C.
AU - Bell, M.
AU - Jensen, R. J.
AU - Gunter, E.
AU - Buchanan, I.
AU - Larned, J.
AU - Kazembe, P. N.
AU - Dobbie, H.
AU - Jarvis, W. R.
T1 - The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2001/12//
VL - 126
IS - 3
M3 - Article
SP - 466
EP - 473
PB - Wiley-Blackwell
SN - 00099104
AB - Worldwide, over 40% of children have iron deficiency anaemia, frequently associated with infections. Certain cytokines are involved in both immune activation/response to infection and iron transport/metabolism. We therefore assessed the relations among iron deficiency, cytokine production and lymphocyte activation markers in 142 hospitalized Malawian children. We examined peripheral blood lymphocyte antigens/cytokine production using four- colour flow cytometry and serum transferrin receptor (TfR) levels, an inverse measure of iron status unaffected by acute illness or infection, with an enzyme-linked immunosorbent assay. Wilcoxon rank sum tests and logistic regression analyses (LRA) were performed. Iron deficiency (TfR ≥ 10 μg/ml) versus TfR < 10 μg/ml, was associated with higher percentages of lymphocytes producing: (a) induced or spontaneous IL-6 (medians: induced, 15·9% for iron-deficient children versus 8·8% for iron-replete children, P = 0·002; spontaneous, 24·4% versus 13·0%, P < 0·001) and (b) induced IFN-γ (medians:18·4% versus 12·4%, P = 0·006). The percentages of CD8+ T cells spontaneously producing IL-6 and of all lymphocytes producing induced TNF-α and IFN-γ in the same cell had the strongest relationships to iron deficiency (b = + 0·0211, P = 0·005 and b = + 0·1158, P = 0·012, respectively, LRA) and were also positively related to the co-expression of the T cell activation markers HLA DR and CD38. Severe iron deficiency (TfR ≥ 30 μg/ml) was associated with the percentage of lymphocytes producing induced IL-4 (medians: 0·5% versus 1·6%, P < 0·010). The cytokine patterns associated with iron deficiency in our study would preserve iron stores but also preferentially retain the activation capabilities of T cells, albeit not necessarily other immune cells, until a critical level of iron depletion is reached. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - IRON
KW - LYMPHOCYTE transformation
KW - CYTOKINES
KW - HEALTH
KW - IMMUNOLOGY
KW - MALAWI
KW - cytokines
KW - IL-4
KW - IL-6
KW - iron deficiency
KW - lymphocyte activation
KW - transferrin receptor
N1 - Accession Number: 5569666; Jason, J. 1 Archibald, L. K. 2 Nwanyanwu, O. C. 3 Bell, M. 2 Jensen, R. J. 4 Gunter, E. 4 Buchanan, I. 1 Larned, J. 1 Kazembe, P. N. 5 Dobbie, H. 5 Jarvis, W. R. 2; Affiliation: 1: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research (DASTLR), 2: Investigation and Prevention Branch, Hospital Infections Program, National Center for Infectious Diseases (NCID); 3: Office of Global Health and 4: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention (CDC), US Department of Health and Human Services (DHHS), US Public Health Service (PHS), Atlanta, GA, USA, and 5: Lilongwe Central Hospital, Ministry of Health and Population, Lilongwe, Malawi, and Community Health Sciences Unit, Ministry of Health and Population, Lilongwe, Malawi; Source Info: Dec2001, Vol. 126 Issue 3, p466; Subject Term: CHILDREN -- Health; Subject Term: IRON; Subject Term: LYMPHOCYTE transformation; Subject Term: CYTOKINES; Subject Term: HEALTH; Subject Term: IMMUNOLOGY; Subject Term: MALAWI; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: IL-4; Author-Supplied Keyword: IL-6; Author-Supplied Keyword: iron deficiency; Author-Supplied Keyword: lymphocyte activation; Author-Supplied Keyword: transferrin receptor; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 8p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2249.2001.01707.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gobburu, J.V.S.
AU - Marroum, P.J.
T1 - Utilisation of Pharmacokinetic- Pharmacodynamic Modelling and Simulation in Regulatory Decision-Making.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2001/12//
VL - 40
IS - 12
M3 - Article
SP - 883
EP - 892
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Modelling and simulation (M&S) play an important role in regulatory decision-making that affects both the public and industry. Technological advances in various fields related to drug development call for more focus on ways to optimise current drug development practices. Recognition of the potential of M&S by regulatory agencies inevitably has a substantial impact on drug development. The objective of the current review is to present the various regulatory initiatives for application of M&S to clinical drug development. The relevant parts of the various recommendations issued by the US Food and Drug Administration (FDA), via guidance documents and advisory committee meeting proceedings, are highlighted. Application of M&S to a variety of activities, such as integrating pharmacokinetic-pharmacodynamic knowledge across a new drug application and designing efficient trials, is discussed. Some of the challenges that pharmaceutical institutions currently face when implementing M&S projects, such as team structure, communication with regulators, training and time constraints, are also presented, and solutions are proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - PHARMACOKINETICS
KW - Pharmacokinetic pharmacodynamic relationships
KW - Regulatory process
N1 - Accession Number: 5692964; Gobburu, J.V.S. 1 Marroum, P.J. 2; Affiliation: 1: Division of Pharmacometrics, United States Food and Drug Administration, Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Rockville, Maryland, USA 2: Division of Pharmaceutical Evaluation - 1, United States Food and Drug Administration, Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Rockville, Maryland, USA; Source Info: 2001, Vol. 40 Issue 12, p883; Subject Term: DRUG development; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: Pharmacokinetic pharmacodynamic relationships; Author-Supplied Keyword: Regulatory process; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn M.
AU - Stryer, Daniel B.
T1 - Racial and Ethnic Disparities and Primary Care Experience.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/12//
VL - 36
IS - 6
M3 - Article
SP - 979
EP - 986
PB - Wiley-Blackwell
SN - 00179124
AB - Multiple studies published in the past decade have confirmed the existence of significant disparities in access, quality and outcomes of care associated with race, ethnicity and socioeconomic position. The majority of studies have examined the experiences of African Americans, but available evidence suggests that other groups, including, Latinos, Native Americans and Asian Americans, are also affected. The consistency of research findings for a wide array of conditions and settings has stimulated strong interest among stakeholders in identifying strategies for addressing this problem. The results of most studies provide intriguing snapshots of unexplained differences in care but, like scattered pieces of a puzzle, do not provide insights regarding the pathways through which race, ethnicity, and socioeconomic position influence overall disparities in health.
KW - RACE discrimination
KW - ETHNIC relations
KW - PRIMARY care (Medicine)
KW - ETHNIC groups
KW - MEDICAL care
KW - SOCIAL problems
N1 - Accession Number: 12183119; Clancy, Carolyn M. 1 Stryer, Daniel B. 1; Affiliation: 1: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality (AHRQ).; Source Info: Dec2001, Vol. 36 Issue 6, p979; Subject Term: RACE discrimination; Subject Term: ETHNIC relations; Subject Term: PRIMARY care (Medicine); Subject Term: ETHNIC groups; Subject Term: MEDICAL care; Subject Term: SOCIAL problems; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kessler, Ronald C.
AU - Bergiund, Patricia A.
AU - Bruce, Martha L.
AU - Koch, J. Randy
AU - Laska, Eugene M.
AU - Leaf, Philip J.
AU - Manderscheid, Ronald W
AU - Rosenheck, Robert A.
AU - Walters, Ellen E.
AU - Wang, Philip S.
T1 - The Prevalence and Correlates of Untreated Serious Mental Illness.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/12//
VL - 36
IS - 6
M3 - Article
SP - 987
EP - 1007
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To identify the number of people in the United States with untreated serious mental illness (SM!) and the reasons for their lack of treatment. Data Source/Study Design. The National Comorbidity Survey; cross-sectional, nationally representative household survey. Data Collection. An operationalization of the SMI definition set forth in the Alcohol, Drug Abuse, and Mental Health Administration Reorganization Act identified individuals with SM! in the 12 months prior to the interview. The presence of SMI then was related to the use of mental health services in the past 12 months. Principal Findings. Of the 6.2 percent of respondents who had SMI in the year prior to interview, fewer than 40 percent received stable treatment. Young adults and those living in non rural areas were more likely to have unmet needs for treatment. The majority of those who received no treatment felt that they did not have an emotional problem requiring treatment. Among those who did recognize this need, 52 percent reported situational barriers, 46 percent reported financial barriers, and 45 percent reported perceived lack of effectiveness as reasons for not seeking treatment. The most commonly reported reason both for Jailing to seek treatment (72 percent) and for treatment dropout (58 percent) was wanting to solve the problem in their own. Conclusions. Although changes in the financing of services are important, they are unlikely by themselves to eradicate unmet need for treatment of SMI. Efforts to increase both self-recognition of need for treatment and the patient centeredness of care also are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL illness
KW - MENTAL health
KW - MENTAL health services
KW - HEALTH services administration
KW - MEDICAL care -- United States
KW - UNITED States
N1 - Accession Number: 12183130; Kessler, Ronald C. 1 Bergiund, Patricia A. 2 Bruce, Martha L. 3 Koch, J. Randy 4 Laska, Eugene M. 5 Leaf, Philip J. 6 Manderscheid, Ronald W 7 Rosenheck, Robert A. 8 Walters, Ellen E. 9 Wang, Philip S. 10; Affiliation: 1: Professor, Department of Health Care Policy. Harvard Medical School, 180 Longwood Avenue. Suite 215, Boston, MA 02115. 2: Institute for Social Research, University of Michigan. 3: Professor of Sociology in Psychiatry, Department of Psychology, Well Medical College of Cornell University. 4: Department of Mental Health, Mental Retardation and Substance Abuse Services, 5: Statistical Science & Epidemiology Division. Nathan S. Kline institute for Psychiatric Research. 6: Department of Mental Hygiene, The Johns Hopkins University. 7: Division of State and Community Systems Development, U.S. Center for Mental Health Services. 8: Psychiatry and Public Health Departments, Yale University and is from the Northeast Program Evaluation Center, VA Medical Center, West Haven, CT. 9: Department of Health Care Policy, Harvard Medical School. 10: Harvard Medical School and Instructor in Medicine, Brigham and Women's Hospital.; Source Info: Dec2001, Vol. 36 Issue 6, p987; Subject Term: MENTAL illness; Subject Term: MENTAL health; Subject Term: MENTAL health services; Subject Term: HEALTH services administration; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mandett, Jeanne S.
AU - Bierman, Arlene S.
AU - Gold, Karen
AU - Zhang, Yi
AU - Ng, Judy H.
AU - Maserejan, Nancy
AU - Hwang, Yi-Ting
AU - Neal J. Meropol
AU - Hadley, Jack
AU - Silliman, Rebecca A.
T1 - Constructs of Burden of Illness in Older Patients with Breast Cancer: A Comparison of Measurement Methods.
JO - Health Services Research
JF - Health Services Research
Y1 - 2001/12//
VL - 36
IS - 6
M3 - Article
SP - 1085
EP - 1107
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. The burden of illness can influence treatment decisions, but there are limited data comparing the performance of different illness burden measures. We assessed the correlations between five previously validated measures of illness burden and global health and physical function and evaluated how each measure correlates with breast cancer treatment patterns in older women. Data Source. A cohort of 718 women > 67 years with early-stage breast cancer formed the study group. Study group. Study Design/Data Collection Methods. The study made a cross-sectional comparison of illness burden measures (Charlson index, Index of Co-existent Diseases, cardiopulmonary burden of illness, patient-specific life expectancy, and disease counts) and physical function and self-rated global health status. Data were collected from records and patient interviews. Principal Findings. All of the measures were significantly correlated with each other and with physical function and self-rated health (p < .001). After controlling for age and stage, life expectancy had the largest effect on surgical treatment, followed by self-rated physical function and health; life expectancy was also independent of physical function. For instance, women with higher life expectancy and better self- rated physical function and health were mote likely to receive breast conservation and radiation than sicker women. Women with higher physical functioning were more likely to receive adjuvant chemotherapy than women with lower functioning. Conclusions. Several measures of illness burden were associated with breast cancer therapy, but each measure accounted for only a small amount of variance in treatment patterns. Future work is needed to develop and validate measures of burden of illness that are feasible, comprehensive, and relevant for diverse clinical and health services objectives. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - CANCER patients
KW - OLDER women -- Diseases
KW - LIFE expectancy
KW - MEDICAL care
KW - THERAPEUTICS
N1 - Accession Number: 12183265; Mandett, Jeanne S. 1 Bierman, Arlene S. 2 Gold, Karen 3 Zhang, Yi 4 Ng, Judy H. 5 Maserejan, Nancy 6 Hwang, Yi-Ting 7 Neal J. Meropol 8 Hadley, Jack 9 Silliman, Rebecca A. 10; Affiliation: 1: Professor, Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, 2233 Wisconsin Avenue, Suite 317, Washington, DC 20007. 2: Physician, Agency for Healthcare Research and Quality, Office of Outcomes and Effectiveness, Rockville, MD. 3: Assistant Professor, Department of Biomathematics and Biostatistics, Institute for Health Care Policy and Research, Georgetown University School of Medicine. 4: Research Assistant, Department of Biomathematics and Biostatistics, Institute for Health Care Policy and Research, Georgetown University School of Medicine. 5: Agency for Healthcare Research and Quality, Center for Outcomes and Effectiveness Research. 6: Lombardi Cancer Center, Georgetown University. 7: Instructor, Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine. 8: Divisions of Medical Science and Population Science, Fox Chase Cancer Center, Philadelphia. 9: Department of Public Policy, Georgetown University. 10: Professor, Boston University Schools of Medicine and Public Health, Departments of Medicine and Epidemiology and Biostatistics.; Source Info: Dec2001, Vol. 36 Issue 6, p1085; Subject Term: BREAST cancer; Subject Term: CANCER patients; Subject Term: OLDER women -- Diseases; Subject Term: LIFE expectancy; Subject Term: MEDICAL care; Subject Term: THERAPEUTICS; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snowden, Lonnie
T1 - Barriers to Effective Mental Health Services for African Americans.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2001/12//
VL - 3
IS - 4
M3 - Article
SP - 181
EP - 187
SN - 15223434
AB - Many African Americans—especially the most marginal—suffer from mental health problems and would benefit from timely access to appropriate forms of care. However, few seek treatment from outpatient providers in the specialty mental health sector and those who do are at risk of dropping out. African Americans visit providers in the general medical sector, although they use another hypothesized alternative to specialty care, voluntary support networks, less than other groups. These help-seeking tendencies may reflect characteristic coping styles and stigma, as well as a lack of resources and opportunities for treatment. More should be learned about differences in need according to location, social standing, and cultural orientation so as to identify treatments and programs that are especially beneficial to African Americans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFRICAN Americans -- Mental health
KW - AFRICAN Americans -- Medical care
KW - MENTAL health consultation
KW - MENTAL health services
KW - HEALTH programs
KW - MANAGED mental health care
KW - African Americans
KW - coping
KW - help seeking
KW - mental illness
KW - treatment
N1 - Accession Number: 50189273; Snowden, Lonnie 1; Email Address: snowden@uclink4.berkeley.edu; Affiliation: 1: Center for Mental Health Services Research and School of Social Welfare, University of California – Berkeley, 120 Haviland Hall Berkeley 94610-7400; Source Info: Dec2001, Vol. 3 Issue 4, p181; Subject Term: AFRICAN Americans -- Mental health; Subject Term: AFRICAN Americans -- Medical care; Subject Term: MENTAL health consultation; Subject Term: MENTAL health services; Subject Term: HEALTH programs; Subject Term: MANAGED mental health care; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: coping; Author-Supplied Keyword: help seeking; Author-Supplied Keyword: mental illness; Author-Supplied Keyword: treatment; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 7p; Document Type: Article
L3 - 10.1023/A:1013172913880
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Caron, A.
AU - Mayer, J.-C.
AU - Menu, P.
AU - Alayash, A.
AU - Marie, P.-Y.
AU - Vigneron, C.
T1 - Measurement of blood volume after haemodilution with haemoglobin-based oxygen carriers by a radiolabelled-albumin method.
JO - Transfusion Medicine
JF - Transfusion Medicine
Y1 - 2001/12//
VL - 11
IS - 6
M3 - Article
SP - 433
EP - 442
PB - Wiley-Blackwell
SN - 09587578
AB - . Recent studies have shown that the use of haemoglobin-based oxygen-carrying solutions (HBOCs) for perioperative haemodilution could significantly reduce the need for packed red blood cells in clinical practice. Though the effects of HBOCs on plasma volume have been characterized in experimental models of volume resuscitation from hypovolaemic shock, little is known about their action in normovolaemic haemodilution conditions. We therefore applied a radiolabelled serumalbumin method to determine blood volume after haemodilution with crosslinked or conjugated haemoglobin, in comparison with a reference solution of hydroxyethyl starch (HES). Three groups of New Zealand white rabbits were studied (n = 7 each group) subjected to moderate exchange transfusion with low molecular weight HES, bis(3,5-dibromosalicyl)fumarate crosslinked haemoglobin (αα-Hb), or dextran-conjugated haemoglobin (Hb-Dex-BTC). HES induced no changes in heart rate and blood pressure. The amplitude and duration of blood pressure increase and bradycardia were similar in both haemoglobin groups. A significant contraction of blood volume (12%) was observed 60 min after haemodilution with αα-Hb, compared to HES and Hb-Dex-BTC. At the same time point, a decrease in absolute haemoglobin (plasma haemoglobin × plasma volume) was also noted. This study suggests that in haemodilution conditions, the specific oncotic properties and circulating persistence of crosslinked and conjugated haemoglobin solutions affect the pattern of blood volume distribution differently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODILUTION
KW - BLOOD volume
KW - HEMOGLOBIN
KW - blood substitute
KW - blood volume
KW - Haemodilution
KW - haemoglobin-based oxygen carriers
N1 - Accession Number: 5721347; Caron, A. 1 Mayer, J.-C. 2 Menu, P. 1 Alayash, A. 3 Marie, P.-Y. 2 Vigneron, C. 1,4; Affiliation: 1: Department of Haematology and Physiology, University Henri Poincaré-Nancy 1, 54001 Nancy, France; 2: Department of Nuclear Medicine, Nancy-Brabois University Hospital, 54511 Vandœuvre-lès-Nancy, France; 3: Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; 4: Department of Transfusion Biology, Nancy-Brabois University Hospital, 54511 Vandœuvre-lès-Nancy, France; Source Info: Dec2001, Vol. 11 Issue 6, p433; Subject Term: HEMODILUTION; Subject Term: BLOOD volume; Subject Term: HEMOGLOBIN; Author-Supplied Keyword: blood substitute; Author-Supplied Keyword: blood volume; Author-Supplied Keyword: Haemodilution; Author-Supplied Keyword: haemoglobin-based oxygen carriers; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1046/j.1365-3148.2001.00337.x
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Harlan Jr., William R.
T1 - Editorial.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Editorial
SP - 1
EP - 4
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - Editorial. Focuses on the developments in alternative medicine from Korea and the United States. Information on acupuncture; Efforts to address the practice of traditional and Western approaches to medical practice; Popularity of evidence-based medicine as a result of the public interest in complementary and alternative medicine.
KW - ALTERNATIVE medicine
KW - MEDICINE -- Practice
KW - ACUPUNCTURE
KW - EVIDENCE-based medicine
N1 - Accession Number: 5921195; Harlan Jr., William R. 1; Affiliation: 1: Public Health Service, National Institutes of Health (NIH), Bethesda, Maryland.; Source Info: Dec2001 Supplement 1, Vol. 7 Issue 6, p1; Subject Term: ALTERNATIVE medicine; Subject Term: MEDICINE -- Practice; Subject Term: ACUPUNCTURE; Subject Term: EVIDENCE-based medicine; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1089/107555301753393715
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harlan Jr., William R.
T1 - Research on Complementary and Alternative Medicine Using Randomized Controlled Trials.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Article
SP - 45
EP - 52
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - In 1998, the National Institutes of Health (NIH) formed the National Center for Complementary and Alternative Medicine (NCCAM) from what had formerly been the Office of Alternative Medicine. This presentation opens with a brief discussion on the history of the NIH and the development of CAM at the NIH before moving on to the work of the NCCAM. The NCCAM is moving toward an integration of CAM therapies into conventional medicine, when there is evidence for the value of CAM. One of twenty-five institutes or centers at the NIH, the NCCAM looks at evidence-based medicine and public health. In this context, "public health" means educating the public about its health. The NCCAM supports training to conduct research and plays an important role in disseminating information to the public and to health providers about what works and what is safe. This evolves into the concept of evidence-based medical and public-health practices, that is, making decisions on the basis of evidence from scientifically rigorous studies that are sufficiently large to provide a confident estimate of biologically and medically important benefits and risks. In the hierarchy of generating scientific evidence, randomized controlled trials are considered the "gold standard." The NCCAM entertains proposals for studies that come spontaneously from investigators, or, upon identifying an existing need that is not being met by the investigative community, the NCCAM can initiate a request for proposals. Every proposal is subjected to a rigorous application and review process. Another possible step in the assessment of the evidence from clinical trials is to do a systematic analysis of several studies to bring together all the information that is available. Systematic reviews of smaller studies that individually might have an insufficient sample size can assist in making treatment decisions, but, importantly, they can lead the NCCAM in the development of future, definitive studies. Training to conduct research is especially important to CAM. This presentation outlines several approaches the NCCAM has to training (see http://nccam.nih.gov). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Alternative & Complementary Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - CLINICAL trials
KW - PUBLIC health administration
N1 - Accession Number: 5921205; Harlan Jr., William R. 1; Affiliation: 1: Public Health Service, National Institutes of Health (NIH), Bethesda, MD.; Source Info: Dec2001 Supplement 1, Vol. 7 Issue 6, p45; Subject Term: ALTERNATIVE medicine; Subject Term: CLINICAL trials; Subject Term: PUBLIC health administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1089/107555301753393805
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harlan Jr., William R.
T1 - New Opportunities and Proven Approaches in Complementary and Alternative Medicine Research at the National Institutes of Health.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2001/12/02/Dec2001 Supplement 1
VL - 7
IS - 6
M3 - Article
SP - 53
EP - 59
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - This presentation describes some of the issues that arise when applying the clinical-trial approach of conventional medicine to complementary and alternative medicine (CAM) modalities. Conventional medicine has been making the evolution to using an evidence base and to making recommendations only when the evidence is strong. The National Center for Complementary Medicine (NCCAM), one of twenty-five Institutes or Centers of the National Institutes of Health (NIH), is working to hold CAM to the same high standards, not by rejecting previous CAM research, but by building on that strong evidence base of what works and what is safe. The process for conventional drug and device development follows an orderly process of preclinical studies (usually on animals), phase I, phase II, and phase III studies (with the large human clinical trial phase taking place in phase III). Today, the randomized controlled trial is recognized as providing the highest level of scientific evidence. This conventional medicine approach to development is now being used to develop complementary and alternative therapies. For instance, the discovery and development of Taxol (Bristol-Meyers Squibb, New York, NY), an extract from the bark of the Pacific yew tree that is now a widely used chemotherapeutic agent, followed the conventional pathway to approval and marketing. But for most CAM products, the pathway is not so straightforward. Most CAM therapies are traditional therapies or new products that are already available to the public. Most of what is known about these therapies is of an anecdotal nature. There has been little isolation of the active principals from the crude product and there has usually been no preclinical testing. This presentation details various approaches and programs that address how to plan and conduct a rigorous clinical trial of a CAM product. And, while it takes a good deal of persistence and a strong focus on what are the critical principals in a trial, I conclude that it is possible to apply randomized controlled trials to most of the CAM modalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Alternative & Complementary Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - CLINICAL trials
KW - DRUG development
N1 - Accession Number: 5921204; Harlan Jr., William R. 1; Affiliation: 1: Public Health Service, National Institutes of Health (NIH), Bethesda, MD.; Source Info: Dec2001 Supplement 1, Vol. 7 Issue 6, p53; Subject Term: ALTERNATIVE medicine; Subject Term: CLINICAL trials; Subject Term: DRUG development; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Document Type: Article
L3 - 10.1089/107555301753393814
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Herzog, Walter
T1 - Simulating the swelling and deformation behaviour in soft tissues using a convective thermal analogy.
JO - BioMedical Engineering OnLine
JF - BioMedical Engineering OnLine
Y1 - 2002/01//
VL - 1
M3 - Article
SP - 8
EP - 11
PB - BioMed Central
SN - 1475925X
AB - Background: It is generally accepted that cartilage adaptation and degeneration are mechanically mediated. Investigating the swelling behaviour of cartilage is important because the stress and strain state of cartilage is associated with the swelling and deformation behaviour. It is well accepted that the swelling of soft tissues is associated with mechanical, chemical, and electrical events. Method: The purpose of the present study was to implement the triphasic theory into a commercial finite element tool (ABAQUS) to solve practical problems in cartilage mechanics. Because of the mathematical identity between thermal and mass diffusion processes, the triphasic model was transferred into a convective thermal diffusion process in the commercial finite element software. The problem was solved using an iterative procedure. Results: The proposed approach was validated using the one-dimensional numerical solutions and the experimental results of confined compression of articular cartilage described in the literature. The time-history of the force response of a cartilage specimen in confined compression, which was subjected to swelling caused by a sudden change of saline concentration, was predicted using the proposed approach and compared with the published experimental data. Conclusion: The advantage of the proposed thermal analogy technique over previous studies is that it accounts for the convective diffusion of ion concentrations and the Donnan osmotic pressure in the interstitial fluid. [ABSTRACT FROM AUTHOR]
AB - Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARTILAGE
KW - SOFT tissue injuries
KW - FINITE element method
KW - HEAT -- Convection
KW - DIFFUSION
KW - EXTRACELLULAR fluid
N1 - Accession Number: 28781969; Wu, John Z. 1; Email Address: jwu@cdc.gov Herzog, Walter 2; Email Address: walter@kin.ucalgary.ca; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Human Performance Laboratory, Faculty of Kinesiology, The University of Calgary, Calgary, Alberta, Canada; Source Info: 2002, Vol. 1, p8; Subject Term: CARTILAGE; Subject Term: SOFT tissue injuries; Subject Term: FINITE element method; Subject Term: HEAT -- Convection; Subject Term: DIFFUSION; Subject Term: EXTRACELLULAR fluid; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Šimák, Jan
AU - Holada, Karel
AU - Vostal, Jaroslav G.
T1 - Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin.
JO - BMC Cell Biology
JF - BMC Cell Biology
Y1 - 2002/01//
VL - 3
M3 - Article
SP - 11
EP - 10
PB - BioMed Central
SN - 14712121
AB - Background: Elevated plasma counts of endothelial microparticles (MP) have been demonstrated in various diseases with a vascular injury component. We used flow cytometry to study the MP-release from cultured human umbilical vein endothelial cells (HUVEC) stimulated by various agonists. MP-release by a topoisomerase I inhibitor camptothecin has been studied in detail. Results: Overnight stimulation of HUVEC with either LPS or TNFα, or 30 min stimulation with thrombin, phorbol-myristate-acetate, tissue plasminogen activator, or angiotensin-II did not cause a significant release of annexin V-binding MP. In contrast, induction of apoptosis with 5 µM camptothecin, documented by 60-70% desquamation of HUVEC culture, annexin V-binding to the cells and DNA-fragmentation, led to a release of annexin V-binding microparticles (~ 80,000 MP/ 10³ cells). This microparticle-release was prevented by Z-Val-Ala-Asp-fluoromethyl-ketone (ZVAD). Lower concentration of camptothecin (500 nM) induced comparable microparticle-release without loss of the culture confluence and without increase in annexin V-binding to the cells or DNA-fragmentation. Analyzed microparticles were free of nucleic acids and 95% of microparticles were 0.3-1 µm in size. Double-labeling flow cytometry assay showed that all annexin V-binding Microparticles expressed CD59 but only approximately 50% of these also expressed CD105. Conclusions: Camptothecin treated HUVEC released different populations of annexin V-binding membrane microparticles at early stage after proapoptotic stimulation before detection of phosphatidylserine exposure on the cells or DNA fragmentation. The microparticle-release was ZVAD sensitive but was not enhanced at the executive phase of apoptosis. These observations offer a new insight into microparticle-release as a marker of endothelial stimulation and injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Cell Biology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIPOCORTINS
KW - FLOW cytometry
KW - CHEMICAL agonists
KW - CAMPTOTHECIN
KW - CELL culture
N1 - Accession Number: 29963005; Šimák, Jan 1; Email Address: simak@cber.fda.gov Holada, Karel 1; Email Address: holada@cber.fda.gov Vostal, Jaroslav G. 1; Email Address: vostal@cber.fda.gov; Affiliation: 1: Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: 2002, Vol. 3, p11; Subject Term: LIPOCORTINS; Subject Term: FLOW cytometry; Subject Term: CHEMICAL agonists; Subject Term: CAMPTOTHECIN; Subject Term: CELL culture; Number of Pages: 10p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manteuffel, Brigitte
AU - Stephens, Robert L.
AU - Santiago, Rolando
T1 - Overview of the National Evaluation of the Comprehensive Community Mental Health Services for Children and Their Families Program and Summary of Current Findings.
JO - Children's Services: Social Policy, Research & Practice
JF - Children's Services: Social Policy, Research & Practice
Y1 - 2002/01//
VL - 5
IS - 1
M3 - Article
SP - 3
EP - 20
PB - Taylor & Francis Ltd
SN - 10939644
AB - In this article we present an overview of descriptive and longitudinal outcome data collected by the national evaluation of the Comprehensive Community Mental Health for Children and Their Families Program. This program, supported by the federal Center for Mental Health Services at the Substance Abuse Mental Health Services Administration, has established systems of care for mental health services in 67 communities throughout the United States. Among the 22 communities receiving grants in 1993 and 1994, descriptive information was collected on 44,640 children who received services. Longitudinal outcome study enrollment included 18,884 children, with data collected on 2,580 children who continued in services through 24 months. The average age of children served was 12.1 years; 61.9% were boys, 54.7% were White, and 60.3% had annual household incomes below $15,000. Primary diagnoses included conduct-related disorders (29.3%), attention deficit hyperactivity disorder (13.6%), and depression or dysthymia (26%). Changes in children's behaviors and functioning were examined to 2 years in services; 44.6% of children exhibited clinically significant improvements in behavioral and emotional symptoms at 2 years, and 49.5% showed similar changes in functional impairment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Children's Services: Social Policy, Research & Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY mental health services for children
KW - COMMUNITY-based social services
KW - FEDERAL aid to child health services
KW - CHILD mental health
KW - SOCIAL science research
KW - LONGITUDINAL method
KW - UNITED States
KW - UNITED States. Substance Abuse & Mental Health Services Administration
N1 - Accession Number: 5877631; Manteuffel, Brigitte 1; Email Address: bmanteuf@macroint.com Stephens, Robert L. 1 Santiago, Rolando 2; Affiliation: 1: ORC Macro, Atlanta, GA 2: Center for Mental Health Services, Substance Abuse and Mental Health Services, Administration Washington, DC; Source Info: 2002, Vol. 5 Issue 1, p3; Subject Term: COMMUNITY mental health services for children; Subject Term: COMMUNITY-based social services; Subject Term: FEDERAL aid to child health services; Subject Term: CHILD mental health; Subject Term: SOCIAL science research; Subject Term: LONGITUDINAL method; Subject Term: UNITED States; Company/Entity: UNITED States. Substance Abuse & Mental Health Services Administration; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 18p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brannan, Ana Maria
AU - Baughman, Lela N.
AU - Reed, Erika D.
AU - Katz-Leavy, Judith
T1 - System-of-Care Assessment: Cross-Site Comparison of Findings.
JO - Children's Services: Social Policy, Research & Practice
JF - Children's Services: Social Policy, Research & Practice
Y1 - 2002/01//
VL - 5
IS - 1
M3 - Article
SP - 37
EP - 56
PB - Taylor & Francis Ltd
SN - 10939644
AB - In this article we describe a system-level assessment that examined the extent to which 8 system-of-care principles (e.g., family-focused care, coordination of services, use of least restrictive service options) were operationalized across 8 system components (e.g., system governance, quality monitoring, case monitoring and review). Data were collected in 3 federally funded systems of care and 3 matched comparison sites. Comparisons of system scores across paired sites suggested that the federal program that funded the systems of care helped those sites come closer than the comparison sites to the ideals articulated in the principles. There was also less variability in scores across the funded systems of care, with greater variability found across the comparison sites' scores. Some movement toward the system-of-care approach was demonstrated in the comparison sites, however, despite their lack of special funding. The systems of care performed especially well in the principles of interagency involvement and community-based service delivery. Although they generally performed better than the comparison sites, the systems of care continued to struggle in their system-level quality improvement efforts and in culturally competent service delivery. [ABSTRACT FROM AUTHOR]
AB - Copyright of Children's Services: Social Policy, Research & Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY-based social services
KW - CARE of people
KW - FUNDRAISING
KW - SOCIAL services -- Finance
KW - EVALUATION
KW - ORGANIZATIONAL structure
KW - INTERAGENCY coordination
N1 - Accession Number: 5877629; Brannan, Ana Maria 1; Email Address: abrannan@macroint.com Baughman, Lela N. 1 Reed, Erika D. 2 Katz-Leavy, Judith 3; Affiliation: 1: ORC Macro, Atlanta, GA 2: Westat, Atlanta, GA 3: Center for Mental Health Services, Rockville, MD; Source Info: 2002, Vol. 5 Issue 1, p37; Subject Term: COMMUNITY-based social services; Subject Term: CARE of people; Subject Term: FUNDRAISING; Subject Term: SOCIAL services -- Finance; Subject Term: EVALUATION; Subject Term: ORGANIZATIONAL structure; Subject Term: INTERAGENCY coordination; NAICS/Industry Codes: 813211 Grantmaking Foundations; NAICS/Industry Codes: 813210 Grant-making and giving services; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 20p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holden, E. Wayne
AU - De Carolis, Gary
AU - Huff, Barbara
T1 - Policy Implications of the National Evaluation of the Comprehensive Community Mental Health Services for Children and Their Families Program.
JO - Children's Services: Social Policy, Research & Practice
JF - Children's Services: Social Policy, Research & Practice
Y1 - 2002/01//
VL - 5
IS - 1
M3 - Article
SP - 57
EP - 65
PB - Taylor & Francis Ltd
SN - 10939644
AB - The Comprehensive Community Mental Health Services for Children and Their Families Program is described. Since its inception, this program has had the goal of using federal resources to facilitate the development of community-based systems of care that will be sustained by state- and local-level resources after federal funding. Much of this work requires a sustained emphasis on the policy implications of the program to influence public policy changes. These policy implications are discussed across multiple target audiences and impact areas at the federal, state, and local levels. The professional training and research communities are highlighted as important audiences to inform to facilitate continued policy change. The relations between data from this program and other recent federal initiatives to support research and evaluation in children's mental health services are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Children's Services: Social Policy, Research & Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY mental health services for children
KW - COMMUNITY-based social services
KW - FEDERAL aid to child health services
KW - SOCIAL services -- Finance
KW - CHILD mental health services
KW - FAMILY services
KW - MENTAL health personnel
KW - SOCIAL workers
KW - TRAINING of
N1 - Accession Number: 5877628; Holden, E. Wayne 1; Email Address: wholden@macroint.com De Carolis, Gary 2 Huff, Barbara 3; Affiliation: 1: ORC Macro, Atlanta, GA 2: Center for Mental Health Services, Substance Abuse and Mental Health Service Administration Rockville, MD 3: Federation of Families for Children's Mental Health Alexandria, VA; Source Info: 2002, Vol. 5 Issue 1, p57; Subject Term: COMMUNITY mental health services for children; Subject Term: COMMUNITY-based social services; Subject Term: FEDERAL aid to child health services; Subject Term: SOCIAL services -- Finance; Subject Term: CHILD mental health services; Subject Term: FAMILY services; Subject Term: MENTAL health personnel; Subject Term: SOCIAL workers; Subject Term: TRAINING of; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jordan, Alexander
T1 - Toxicology of progestogens of implantable contraceptives for women1 1 From reviews of data submitted to the US FDA to support NDA.☆ The views expressed in this paper are those of the authors, and do not necessarily represent the views or policies of the US Environmental Protection Agency or the Food, and Drug Administration.(2000) . This approach is very useful especially when there exist a large number of parameters of interest to be estimated and many nonlinear inequality constraints. A Monte Carlo simulation study is conducted to evaluate the computational efficiency and accuracy of the estimates obtained from the new approach. The advantages of using the Newton-based approach are illustrated with a real data set. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUMERICAL analysis
KW - CARCINOGENICITY
KW - BIOMATHEMATICS
KW - Cause of death
KW - Inequality constraint
KW - Maximum likelihood
KW - Optimization
KW - Sacrifice
N1 - Accession Number: 7739780; Ahn, Hongshik 1; Email Address: hahn@ams.sunysb.edu Moon, Hojin 2; Email Address: hmoon@mail.mdanderson.org Kim, Sunyoung 3; Email Address: skim@math.ewha.ac.kr Kodell, Ralph L. 4; Email Address: rkodell@nctr.fda.gov; Affiliation: 1: Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, NY 11794-3600, USA 2: Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 447, Houston, TX 77030-4009, USA 3: Department of Mathematics, Ewha Women's University, Daehyun-dong, Seoul, 120-750, South Korea 4: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Jan2002, Vol. 38 Issue 3, p263; Subject Term: NUMERICAL analysis; Subject Term: CARCINOGENICITY; Subject Term: BIOMATHEMATICS; Author-Supplied Keyword: Cause of death; Author-Supplied Keyword: Inequality constraint; Author-Supplied Keyword: Maximum likelihood; Author-Supplied Keyword: Optimization; Author-Supplied Keyword: Sacrifice; Number of Pages: 21p; Document Type: Article
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ER -
TY - JOUR
AU - Aardema, Marilyn J.
AU - MacGregor, James T.
T1 - Toxicology and genetic toxicology in the new era of “toxicogenomics”: impact of “-omics” technologies
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/01/29/
VL - 499
IS - 1
M3 - Article
SP - 13
SN - 00275107
AB - The unprecedented advances in molecular biology during the last two decades have resulted in a dramatic increase in knowledge about gene structure and function, an immense database of genetic sequence information, and an impressive set of efficient new technologies for monitoring genetic sequences, genetic variation, and global functional gene expression. These advances have led to a new sub-discipline of toxicology: “toxicogenomics”. We define toxicogenomics as “the study of the relationship between the structure and activity of the genome (the cellular complement of genes) and the adverse biological effects of exogenous agents”. This broad definition encompasses most of the variations in the current usage of this term, and in its broadest sense includes studies of the cellular products controlled by the genome (messenger RNAs, proteins, metabolites, etc.). The new “global” methods of measuring families of cellular molecules, such as RNA, proteins, and intermediary metabolites have been termed “-omic” technologies, based on their ability to characterize all, or most, members of a family of molecules in a single analysis. With these new tools, we can now obtain complete assessments of the functional activity of biochemical pathways, and of the structural genetic (sequence) differences among individuals and species, that were previously unattainable. These powerful new methods of high-throughput and multi-endpoint analysis include gene expression arrays that will soon permit the simultaneous measurement of the expression of all human genes on a single “chip”. Likewise, there are powerful new methods for protein analysis (proteomics: the study of the complement of proteins in the cell) and for analysis of cellular small molecules (metabonomics: the study of the cellular metabolites formed and degraded under genetic control). This will likely be extended in the near future to other important classes of biomolecules such as lipids, carbohydrates, etc. These assays provide a general capability for global assessment of many classes of cellular molecules, providing new approaches to assessing functional cellular alterations. These new methods have already facilitated significant advances in our understanding of the molecular responses to cell and tissue damage, and of perturbations in functional cellular systems.As a result of this rapidly changing scientific environment, regulatory and industrial toxicology practice is poised to undergo dramatic change during the next decade. These advances present exciting opportunities for improved methods of identifying and evaluating potential human and environmental toxicants, and of monitoring the effects of exposures to these toxicants. These advances also present distinct challenges. For example, the significance of specific changes and the performance characteristics of new methods must be fully understood to avoid misinterpretation of data that could lead to inappropriate conclusions about the toxicity of a chemical or a mechanism of action. We discuss the likely impact of these advances on the fields of general and genetic toxicology, and risk assessment. We anticipate that these new technologies will (1) lead to new families of biomarkers that permit characterization and efficient monitoring of cellular perturbations, (2) provide an increased understanding of the influence of genetic variation on toxicological outcomes, and (3) allow definition of environmental causes of genetic alterations and their relationship to human disease. The broad application of these new approaches will likely erase the current distinctions among the fields of toxicology, pathology, genetic toxicology, and molecular genetics. Instead, a new integrated approach will likely emerge that involves a comprehensive understanding of genetic control of cellular functions, and of cellular responses to alterations in normal molecular structure and function. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC toxicology
KW - MOLECULAR biology
KW - Biomarkers
KW - Gene expression
KW - Genetic toxicology
KW - Microarrays
KW - Toxicogenomics
N1 - Accession Number: 7745498; Aardema, Marilyn J. 1; Email Address: aardema.mj@pg.com MacGregor, James T. 2; Affiliation: 1: Miami Valley Laboratories, The Procter & Gamble Co., P.O. Box 538707, Cincinnati, OH 45253, USA 2: US Food and Drug Administration, National Center for Toxicological Research, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: Jan2002, Vol. 499 Issue 1, p13; Subject Term: GENETIC toxicology; Subject Term: MOLECULAR biology; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Genetic toxicology; Author-Supplied Keyword: Microarrays; Author-Supplied Keyword: Toxicogenomics; Number of Pages: 13p; Document Type: Article
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ER -
TY - JOUR
AU - Park, Hoon
AU - Hung, Yen-Con
AU - Brackett, Robert E.
T1 - Antimicrobial effect of electrolyzed water for inactivating Campylobacter jejuni during poultry washing
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2002/01/30/
VL - 72
IS - 1/2
M3 - Article
SP - 77
SN - 01681605
AB - The effectiveness of electrolyzed (EO) water for killing Campylobacter jejuni on poultry was evaluated. Complete inactivation of C. jejuni in pure culture occurred within 10 s after exposure to EO or chlorinated water, both of which contained 50 mg/l of residual chlorine. A strong bactericidal activity was also observed on the diluted EO water (containing 25 mg/l of residual chlorine) and the mean population of C. jejuni was reduced to less than 10 CFU/ml (detected only by enrichment for 48 h) after 10-s treatment. The diluted chlorine water (25 mg/l residual chlorine) was less effective than the diluted EO water for inactivation of C. jejuni. EO water was further evaluated for its effectiveness in reducing C. jejuni on chicken during washing. EO water treatment was equally effective as chlorinated water and both achieved reduction of C. jejuni by about 3 log10 CFU/g on chicken, whereas deionized water (control) treatment resulted in only 1 log10 CFU/g reduction. No viable cells of C. jejuni were recovered in EO and chlorinated water after washing treatment, whereas high populations of C. jejuni (4 log10 CFU/ml) were recovered in the wash solution after the control treatment. Our study demonstrated that EO water was very effective not only in reducing the populations of C. jejuni on chicken, but also could prevent cross-contamination of processing environments. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER
KW - POULTRY
KW - Campylobacter jejuni
KW - Chicken
KW - Chlorine water
KW - Electrolyzed water
KW - Hypochlorous acid
KW - Poultry
N1 - Accession Number: 7741974; Park, Hoon 1 Hung, Yen-Con 1; Email Address: YHUNG@GAES.GRIFFIN.PEACHNET.EDU Brackett, Robert E. 2; Affiliation: 1: Department of Food Science and Technology, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA 30223-1797, USA 2: Office of Plant and Dairy Foods and Beverages, Food and Drug Administration, 200 C Street SW, Washington, DC 20204, USA; Source Info: Jan2002, Vol. 72 Issue 1/2, p77; Subject Term: CAMPYLOBACTER; Subject Term: POULTRY; Author-Supplied Keyword: Campylobacter jejuni; Author-Supplied Keyword: Chicken; Author-Supplied Keyword: Chlorine water; Author-Supplied Keyword: Electrolyzed water; Author-Supplied Keyword: Hypochlorous acid; Author-Supplied Keyword: Poultry; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 7p; Document Type: Article
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ER -
TY - JOUR
AU - Golding, Basil
AU - Eller, Nancy
AU - Levy, Lily
AU - Beining, Paul
AU - Inman, John
AU - Matthews, Natasha
AU - Scott, Dorothy E.
AU - Golding, Hana
T1 - Mucosal immunity in mice immunized with HIV-1 peptide conjugated to Brucella abortus
JO - Vaccine
JF - Vaccine
Y1 - 2002/01/31/
VL - 20
IS - 9/10
M3 - Article
SP - 1445
SN - 0264410X
AB - We have previously shown that a V3-loop peptide from HIV-1 envelope conjugated to heat-inactivated Brucella abortus (Ba) (V3-Ba) is capable of inducing antibodies that neutralize HIV-1 and cytotoxic T cells (CTL) that kill HIV-1-infected targets, even in mice that lack CD4+ T cells. In this paper we show that intranasal (i.n.) immunization elicits neutralizing antibodies and IFNγ-secreting T cells at mucosal surfaces. This approach may protect individuals from HIV-1 infection and reduce transmission from infected individuals to their sexual partners and offspring. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEPTIDES
KW - BRUCELLA abortus
KW - IMMUNITY
KW - Brucella abortus
KW - HIV-1
KW - Mucosal immunity
N1 - Accession Number: 8663487; Golding, Basil 1; Email Address: golding@cber.fda.gov Eller, Nancy 1 Levy, Lily 1 Beining, Paul 1 Inman, John 2 Matthews, Natasha 1 Scott, Dorothy E. 1 Golding, Hana 3; Affiliation: 1: Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Woodmont, Rockville Pike, Rockville, MD 20852, USA 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 3: Laboratory of Retrovirus Research, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Source Info: Jan2002, Vol. 20 Issue 9/10, p1445; Subject Term: PEPTIDES; Subject Term: BRUCELLA abortus; Subject Term: IMMUNITY; Author-Supplied Keyword: Brucella abortus; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: Mucosal immunity; Number of Pages: 6p; Document Type: Article
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TY - JOUR
AU - Zey, John N.
AU - Stewart, Patricia A.
AU - Hornung, Richard
AU - Herrick, Robert
AU - McCammon, Charles
AU - Zaebst, Dennis
AU - Pottern, Linda M.
AU - Dosemeci, Mustafa
AU - Bloom, Thomas F.
T1 - Evaluation of Concurrent Personal Measurements of Acrylonitrile Using Different Sampling Techniques.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/02//
VL - 17
IS - 2
M3 - Article
SP - 88
EP - 95
SN - 1047322X
AB - In a retrospective assessment of employee exposure to acrylonitrile (AN) for an epidemiological study, investigators from the National Cancer Institute (NCI) and the National Institute for Occupational Safety and Health (NIOSH) evaluated the feasibility of using historic acrylonitrile air samples without modification. The evaluation discussed here was to determine whether the air sampling results across plants were comparable. During site visits to each plant conducted between 1984 and 1986, study investigators collected personal air samples for four days on approximately ten jobs per day. During these visits, IHs at seven of the eight plants also collected personal samples to compare their sample values to the study-collected sample values. Each plant's IH collected these concurrent measurements for their own use and independent of the IHs at the other plants. The plant IHs had no common sampling protocol but, rather, used professional judgment in deciding sampling logistics for their concurrent measurement. In addition, each plant IH used a different laboratory to analyze samples (the study industrial hygienists used one laboratory). Three sampling methods were used by plant industrial hygienists to collect concurrent measurements: charcoal tubes, passive monitors, and porous polymer tubes. The study investigators only used charcoal tubes. Two hundred and sixty four (264) pairs of concurrent measurements were collected. To assess the + / - comparability of the data sets, paired-observation tests were used. The two sets of charcoal tubes were found to compare favorably with each other. The study's charcoal tubes were 1.2 times higher than results from plant passive monitors. No correlation was found between the study's charcoal tube results and plant porous polymer tube results, although the means for 34 pairs of samples were equivalent. As a result of this evaluation, the investigators decided that no adjustments would be made to the plant measurements. This type of evaluation should be considered when using measurement data in multisite epidemiological studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLONITRILE
KW - PLANTS
KW - POROUS materials
KW - Acrylonitrile
KW - CONCURRENT MEASUREMENTS
KW - FIELD SAMPLE VARIABILITY
KW - PERSONAL SAMPLES
N1 - Accession Number: 5877655; Zey, John N. 1 Stewart, Patricia A. 2 Hornung, Richard 3 Herrick, Robert 4 McCammon, Charles 5 Zaebst, Dennis 6 Pottern, Linda M. 7 Dosemeci, Mustafa 2 Bloom, Thomas F. 6; Affiliation: 1: Department of Safety Science and Technology, Central Missouri State University, Warrensburg, Missouri 2: National Cancer Institute, Rockville, Maryland 3: Institute for Health Policy and Health Services Research, University of Cincinnati Medical Center, Cincinnati, Ohio 4: Department of Environmental Health, Harvard University, Boston, Massachusetts 5: Tri-County Health Department, Commerce City, Colorado 6: National Institute for Occupational Safety and Health, Cincinnati, Ohio 7: Office of Disease Prevention, National Institutes of Health, Bethesda, Maryland; Source Info: Feb2002, Vol. 17 Issue 2, p88; Subject Term: ACRYLONITRILE; Subject Term: PLANTS; Subject Term: POROUS materials; Author-Supplied Keyword: Acrylonitrile; Author-Supplied Keyword: CONCURRENT MEASUREMENTS; Author-Supplied Keyword: FIELD SAMPLE VARIABILITY; Author-Supplied Keyword: PERSONAL SAMPLES; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/104732202317201320
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ER -
TY - JOUR
AU - Dobroski Jr, Harry
AU - Tuchman, Donald P.
AU - Vinson, Robert P.
AU - Timko, Robert J.
T1 - Differential Pressure Response of 25-mm-Diameter Glass Fiber Filters Challenged with Coal and Limestone Dust Mixtures.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/02//
VL - 17
IS - 2
M3 - Article
SP - 96
EP - 103
SN - 1047322X
AB - This article summarizes results of research conducted by the National Institute for Occupational Safety and Health (NIOSH) at its Pittsburgh Research Laboratory. The objective of this work was to determine the correlation between the mass (M) of respirable coal and limestone dusts collected on 25-mm-diameter glass fiber filters mounted in cassettes and the increase in differential pressure (ΔP) that develops across the filters when drawing at constant air flow. Test aerosols were generated inside a laboratory dust chamber using various coal dusts, limestone dust, and mixes of the two. Dusts with different particle size distributions were deposited on the filters by sampling from the chamber through cyclone preclassifiers at different flow rates. Results show that the relationship between differential pressure increase (cm water) and dust mass (mg) is linear and can be approximated by the equation ΔP = KM. The K values (slopes) range from 1.14 to 1.64, depending on the parent coal of the samples. The influence of particle size distribution was also found. The overall K value for all the data summarized in this article is 1.35, with R[sup 2]= 0.84 for the summary equation. When calibrated for individual work sites, or other circumstances where great variability in dust characteristics is avoided, the relationship between collected dust mass and increase in differential pressure may provide an exploitable principle for measurement of respirable dust concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DUST
KW - MINERAL industries
KW - GLASS fibers
KW - LUNG diseases
KW - EMPLOYEES
KW - HEALTH
KW - PENNSYLVANIA
KW - PITTSBURGH (Pa.)
KW - UNITED States
KW - Coal dust
KW - differential pressure
KW - Dust measurement
KW - Dust monitoring
KW - FILTERS
KW - Pressure drop
N1 - Accession Number: 5877654; Dobroski Jr, Harry 1 Tuchman, Donald P. 1 Vinson, Robert P. 1 Timko, Robert J. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, Pennsylvania; Source Info: Feb2002, Vol. 17 Issue 2, p96; Subject Term: DUST; Subject Term: MINERAL industries; Subject Term: GLASS fibers; Subject Term: LUNG diseases; Subject Term: EMPLOYEES; Subject Term: HEALTH; Subject Term: PENNSYLVANIA; Subject Term: PITTSBURGH (Pa.); Subject Term: UNITED States; Author-Supplied Keyword: Coal dust; Author-Supplied Keyword: differential pressure; Author-Supplied Keyword: Dust measurement; Author-Supplied Keyword: Dust monitoring; Author-Supplied Keyword: FILTERS; Author-Supplied Keyword: Pressure drop; NAICS/Industry Codes: 327212 Other Pressed and Blown Glass and Glassware Manufacturing; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327993 Mineral Wool Manufacturing; NAICS/Industry Codes: 326193 Motor vehicle plastic parts manufacturing; NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/104732202317201339
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TY - JOUR
AU - Earnest, G. Scott
AU - Ewers, Lynda M.
AU - Ruder, Avima M.
AU - Petersen, Martin R.
AU - Kovein, Ronald J.
T1 - An Evaluation of Retrofit Engineering Control Interventions to Reduce Perchloroethylene Exposures in Commercial Dry-Cleaning Shops.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/02//
VL - 17
IS - 2
M3 - Article
SP - 104
EP - 111
SN - 1047322X
AB - Real-time monitoring was used to evaluate the ability of engineering control devices retrofitted on two existing dry-cleaning machines to reduce worker exposures to perchloroethylene. In one dry-cleaning shop, a refrigerated condenser was installed on a machine that had a water-cooled condenser to reduce the air temperature, improve vapor recovery, and lower exposures. In a second shop, a carbon adsorber was retrofitted on a machine to adsorb residual perchloroethylene not collected by the existing refrigerated condenser to improve vapor recovery and reduce exposures. Both controls were successful at reducing the perchloroethylene exposures of the dry-cleaning machine operator. Real-time monitoring was performed to evaluate how the engineering controls affected exposures during loading and unloading the dry-cleaning machine, a task generally considered to account for the highest exposures. The real-time monitoring showed that dramatic reductions occurred in exposures during loading and unloading of the dry-cleaning machine due to the engineering controls. Peak operator exposures during loading and unloading were reduced by 60 percent in the shop that had a refrigerated condenser installed on the dry-cleaning machine and 92 percent in the shop that had a carbon adsorber installed. Although loading and unloading exposures were dramatically reduced, drops in full-shift time-weighted average (TWA) exposures were less dramatic. TWA exposures to perchloroethylene, as measured by conventional air sampling, showed smaller reductions in operator exposures of 28 percent or less. Differences between exposure results from realtime and conventional air sampling very likely resulted from other uncontrolled sources of exposure, differences in shop general ventilation before and after the control was installed, relatively small sample sizes, and experimental variability inherent in field research. Although there were some difficulties and complications with installation and maintenance of the engineering controls, this study showed that retrofitting engineering controls may be a feasible option for some dry-cleaning shop owners to reduce worker exposures to perchloroethylene. By installing retrofit controls, a dry-cleaning facility can reduce exposures, in some cases dramatically, and bring operators into compliance with the Occupational Safety and Health Administration (OSHA) peak exposure limit of 300 ppm. Retrofit engineering controls are also likely to enable many dry-cleaning workers to lower their overall personal TWA exposures to perchloroethylene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACHLOROETHYLENE
KW - DRY cleaning machines
KW - ADSORPTION
KW - CARBON
KW - UNITED States
KW - DRY CLEAN
KW - Engineering controls
KW - INTERVENTIONS
KW - PERCHLOROETHYLENE
N1 - Accession Number: 5877653; Earnest, G. Scott 1 Ewers, Lynda M. 1 Ruder, Avima M. 1 Petersen, Martin R. 1 Kovein, Ronald J. 1; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Feb2002, Vol. 17 Issue 2, p104; Subject Term: TETRACHLOROETHYLENE; Subject Term: DRY cleaning machines; Subject Term: ADSORPTION; Subject Term: CARBON; Subject Term: UNITED States; Author-Supplied Keyword: DRY CLEAN; Author-Supplied Keyword: Engineering controls; Author-Supplied Keyword: INTERVENTIONS; Author-Supplied Keyword: PERCHLOROETHYLENE; NAICS/Industry Codes: 417920 Service establishment machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333318 Other Commercial and Service Industry Machinery Manufacturing; NAICS/Industry Codes: 333310 Commercial and service industry machinery manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/104732202317201348
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ER -
TY - JOUR
AU - Ewers, Lynda M.
AU - Ruder, Avima M.
AU - Petersen, Martin R.
AU - Earnest, G. Scott
AU - Goldenhar, Linda M.
T1 - Effects of Retrofit Emission Controls and Work Practices on Perchloroethylene Exposures in Small Dry-Cleaning Shops.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/02//
VL - 17
IS - 2
M3 - Article
SP - 112
EP - 120
SN - 1047322X
AB - The effectiveness of commercially available interventions for reducing workers' perchloroethylene exposures in three small dry-cleaning shops was evaluated. Depending upon machine configuration, the intervention consisted of the addition of either a refrigerated condenser or a closed-loop carbon adsorber to the existing dry-cleaning machine. These relatively inexpensive (less than $5000) engineering controls were designed to reduce perchloroethylene emissions when dry-cleaning machine doors were opened for loading or unloading. Effectiveness of the interventions was judged by comparing pre- and postintervention perchloroethylene exposures using three types of measurements in each shop: (1) full-shift, personal breathing zone, air monitoring, (2) next-morning, end-exhaled worker breath concentrations of perchloroethylene, and (3) differences in the end - exhaled breath perchloroethylene concentrations before and after opening the dry-cleaning machine door. In general, measurements supported the hypothesis that machine operators' exposures to perchloroethylene can be reduced. However, work practices, especially maintenance practices, influenced exposures more than was originally anticipated. Only owners of dry-cleaning machines in good repair, with few leaks, should consider retrofitting them, and only after consultation with their machine's manufacturer.If machines are in poor condition, a new machine or alternative technology should be considered. Shop owners and employees should never circumvent safety features on dry-cleaning machines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACHLOROETHYLENE
KW - DRY cleaning machines
KW - UNITED States
KW - Dry-cleaning
KW - intervention studies
KW - PERCHLOROETHYLENE
KW - Small business
KW - work practices
N1 - Accession Number: 5877652; Ewers, Lynda M. 1 Ruder, Avima M. 1 Petersen, Martin R. 1 Earnest, G. Scott 1 Goldenhar, Linda M. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Feb2002, Vol. 17 Issue 2, p112; Subject Term: TETRACHLOROETHYLENE; Subject Term: DRY cleaning machines; Subject Term: UNITED States; Author-Supplied Keyword: Dry-cleaning; Author-Supplied Keyword: intervention studies; Author-Supplied Keyword: PERCHLOROETHYLENE; Author-Supplied Keyword: Small business; Author-Supplied Keyword: work practices; NAICS/Industry Codes: 417920 Service establishment machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333318 Other Commercial and Service Industry Machinery Manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 333310 Commercial and service industry machinery manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 9p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1080/104732202317201357
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DB - aph
ER -
TY - JOUR
AU - SUZUKI, K.
AU - YANAGI, M.
AU - MORI-AOKI, A.
AU - MORIYAMA, E.
AU - ISHII, K. J.
AU - KOHN, L. D.
T1 - Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2002/02//
VL - 127
IS - 2
M3 - Article
SP - 234
EP - 242
PB - Wiley-Blackwell
SN - 00099104
AB - SUMMARY Although infection of single-stranded RNA viruses can enhance expression of major histocompatibility complex (MHC) class I genes, the mechanism underlying this process remains unclear. Recent studies have indicated that exposure of non-immune cells to double-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) of viral origin can directly increase the expression of MHC class I and related molecules without immune cell interaction. In this report, we show that transfection of single-stranded hepatitis A virus RNA into cultured hepatocytes results in the induction of genes for MHC class I, LMP2 and transporter for antigen processing (TAP1), in addition to the generation of viral proteins. We suggest that this stimulatory effect is due to the double-stranded RNA formed during replication of single-stranded viral RNA, and involves both double-stranded, RNA-dependent protein kinase PKR and the secretion of IFNβ. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE transfection
KW - HEPATITIS A virus
KW - RNA
KW - antigen presentation
KW - infectious immunity-virus
KW - MHC
KW - Protein kinases/phosphatases
N1 - Accession Number: 6290575; SUZUKI, K. 1,2 YANAGI, M. 3 MORI-AOKI, A. 1,4 MORIYAMA, E. 1 ISHII, K. J. 5 KOHN, L. D. 1,6; Affiliation: 1: Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Maryland, USA, 2: Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan, 3: Department of Internal Medicine, Kanazawa University School of Medicine, Ishikawa, Japan, 4: Department of Internal Medicine, Tottori University School of Medicine, Tottori, Japan, 5: Section of Retroviral Immunology, Center for Biologics, Evaluation, and Research, Food and Drug Administration, Maryland, USA, and 6: Edison Biotechnology Institute, Ohio University College of Medicine, Athens, OH, USA; Source Info: Feb2002, Vol. 127 Issue 2, p234; Subject Term: GENE transfection; Subject Term: HEPATITIS A virus; Subject Term: RNA; Author-Supplied Keyword: antigen presentation; Author-Supplied Keyword: infectious immunity-virus; Author-Supplied Keyword: MHC; Author-Supplied Keyword: Protein kinases/phosphatases; Number of Pages: 9p; Illustrations: 4 Black and White Photographs, 7 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1046/j.1365-2249.2002.01767.x
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ER -
TY - JOUR
AU - Marroum, P.J.
AU - Gobburu, J.
T1 - The Product Label: How Pharmacokinetics and Pharmacodynamics Reach the Prescriber.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2002/02//
VL - 41
IS - 3
M3 - Article
SP - 161
EP - 169
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - The product label, or package insert, is the ‘manual’ for the safe and effective use of a drug. Important pharmacokinetic and pharmacodynamic properties of a drug product should appear in the label under specific sections, as required in the Code of Federal Regulations (CFR), using a format and language recommended by the Food and Drug Administration (FDA) in various guidances to the industry. The relevant regulations and guidance documents impacting on how this information is conveyed to the healthcare professional are discussed, with special emphasis on how the new proposed rule will impact upon how information is to be conveyed. With the availability of new clinical pharmacology information not available at the time of approval, package inserts for older drugs should be updated to reflect the new data and recommend the proper dosage regimen, enabling prescribers to optimise drug therapy and minimise possible adverse events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Packaging
KW - LABELS -- Law & legislation
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - Labelling
KW - Package Inserts
KW - Prescribing
N1 - Accession Number: 6398531; Marroum, P.J. 1 Gobburu, J. 1; Affiliation: 1: Division of Pharmaceutical Evaluation, Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2002, Vol. 41 Issue 3, p161; Subject Term: DRUGS -- Packaging; Subject Term: LABELS -- Law & legislation; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Author-Supplied Keyword: Labelling; Author-Supplied Keyword: Package Inserts; Author-Supplied Keyword: Prescribing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); Number of Pages: 9p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Wang, Sue-Jane
AU - Hung, H.M. James
AU - Tsong, Yi
T1 - Utility and pitfalls of some statistical methods in active controlled clinical trials
JO - Controlled Clinical Trials
JF - Controlled Clinical Trials
Y1 - 2002/02//
VL - 23
IS - 1
M3 - Article
SP - 15
SN - 01972456
AB - Increasingly often, the study objective in an active controlled clinical trial without a placebo arm is to show that a new treatment is no less effective than the active control treatment within some noninferiority range. Two issues behind this objective are that of whether the new treatment is efficacious relative to a putative placebo and that of whether the new treatment preserves a certain fraction of effect of the active control. To address these issues, two types of statistical analysis methods are employed in recent pharmaceutical applications. In one type of method, a noninferiority margin is determined, and then the relative effect of the new treatment versus the control is compared against the margin to test noninferiority and the efficacy of the new treatment. In the other type of method, a synthetic statistic is constructed to directly estimate or test the effect of the new treatment relative to the putative placebo without resorting to noninferiority argument. Preservation of control effect can also be estimated and tested. These methods carry some crucial assumptions. The effect of active control is often estimated from a collection of historical placebo controlled trials using the random effects modeling of DerSimonian and Laird. In this work we find that statistical validity of the latter method rests highly on the assumptions that control effect is not reduced in the current active controlled trial population compared to the historical trials and that a normal approximation is appropriate in the random effects modeling. This type of method is very sensitive to departure from these assumptions. In contrast, the former method is ultraconservative in terms of type I error when the assumptions are met and can be anticonservative when control effect is substantially less in the active controlled trial than estimated from the historical placebo controlled trials. [Copyright &y& Elsevier]
AB - Copyright of Controlled Clinical Trials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLACEBOS (Medicine)
KW - CONTROL theory (Mathematics)
KW - Indirect confidence interval comparison
KW - Noninferiority margin
KW - Preservation of control effect
KW - Putative placebo
KW - Random effects
KW - Virtual comparison
N1 - Accession Number: 8799523; Wang, Sue-Jane 1; Email Address: wangs@cder.fda.gov Hung, H.M. James 2 Tsong, Yi 3; Affiliation: 1: Division of Biometrics II, Office of Biostatistics, Center of Drug Evaluation and Resesarch, Food and Drug Administration, Rockville, MD, USA 2: Division of Biometrics I, Office of Biostatistics, Center of Drug Evaluation and Resesarch, Food and Drug Administration, Rockville, MD, USA 3: Quantitative Methods Research, Office of Biostatistics, Center of Drug Evaluation and Resesarch, Food and Drug Administration, Rockville, MD, USA; Source Info: Feb2002, Vol. 23 Issue 1, p15; Subject Term: PLACEBOS (Medicine); Subject Term: CONTROL theory (Mathematics); Author-Supplied Keyword: Indirect confidence interval comparison; Author-Supplied Keyword: Noninferiority margin; Author-Supplied Keyword: Preservation of control effect; Author-Supplied Keyword: Putative placebo; Author-Supplied Keyword: Random effects; Author-Supplied Keyword: Virtual comparison; Number of Pages: 14p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Ellenberg, S.S.
AU - Braun, M.M.
T1 - Monitoring the Safety of Vaccines: Assessing the Risks.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/02//
VL - 25
IS - 3
M3 - Article
SP - 145
EP - 152
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - The safety of vaccines, particularly the most widely used vaccines to which most children are exposed as infants and toddlers, has always been an extremely high priority for vaccine manufacturers and government agencies. Products intended for healthy people must be held to a high standard of safety assurance. In addition to the intense safety assessments conducted prior to licensure, post-marketing surveillance programmes are essential to identify and study possible risks that occur too rarely to have been identified in pre-licensure studies or that occur in populations not studied in pre-licensure studies. Studying rare risks of vaccines is more complex than for therapeutic products because the exposure is virtually universal for many vaccines, ensuring occurrence simply by chance of many adverse outcomes in temporal association with vaccination. In the US the Vaccine Safety Datalink (VSD), a consortium of managed care organisations, has been established to study more rigourously possible vaccine-associated risks. These risks may be identified through reports to the Vaccine Adverse Event Reporting System (VAERS), the nationwide passive surveillance programme, as well as other sources. The combination of passive surveillance and more structured case-control or cohort studies possible in the VSD has helped to both identify new vaccine risks and to provide reassuring evidence of lack of risk in other situations where concerns have been raised. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - COMMUNICABLE diseases
KW - Adverse reaction monitoring
KW - Vaccines, adverse reactions
N1 - Accession Number: 6484378; Ellenberg, S.S. 1 Braun, M.M. 1; Affiliation: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2002, Vol. 25 Issue 3, p145; Subject Term: VACCINES; Subject Term: COMMUNICABLE diseases; Author-Supplied Keyword: Adverse reaction monitoring; Author-Supplied Keyword: Vaccines, adverse reactions; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Weagant, S. D.
AU - Feng, P. C. H.
T1 - Comparative analysis of a modified rapid presence/absence test and the standard MPN method for detectingEscherichia coli in orange juice
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/02//
VL - 19
IS - 1
M3 - Article
SP - 111
SN - 07400020
AB - A modified rapid presence/absence test was evaluated and compared to the standard most probable number (MPN) method for detecting Escherichia coli in artificially contaminated orange juice. In each of the four experiments conducted, pasteurized and unpasteurized orange juice samples were seeded with one of the three different strains ofE. coli , at levels ranging from 0·4 to 6·5 cfu ml−1. The samples were also seeded with 360–510 cfu ml−1 of other enteric bacteria to simulate background flora. Samples were analysed by the MPN method for E. coli and by the modified ColiComplete (CC) presence/absence test in E. coli (EC) broth at 44·5°C, after pre-enriching 10 ml of juice samples in Universal Pre-enrichment Broth for 24 h (modified CC method). Of the 12 comparative analyses performed, E. coli was detected in all 12 tests by the modified CC method and, furthermore, showed the presence of E. coli in 59 of the 60 (98·3%) orange juice replicates that were examined. In contrast, the standard MPN method was only able to quantify detectable levels of E. coli in eight of 12 tests. The modified CC procedure was faster, required less media and reagents, enabled analysis of 10 ml samples and was more reliable than the standard MPN method for determining the presence or absence of E. coli in artificially contaminated orange juice. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAPID methods (Microbiology)
KW - ESCHERICHIA coli
KW - ORANGE juice
N1 - Accession Number: 8501348; Weagant, S. D. 1 Feng, P. C. H. 2; Affiliation: 1: Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA, 98021-4421, USA 2: Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-516, 200 C St. SW, Washington, DC, 20204, USA; Source Info: Feb2002, Vol. 19 Issue 1, p111; Subject Term: RAPID methods (Microbiology); Subject Term: ESCHERICHIA coli; Subject Term: ORANGE juice; Number of Pages: 5p; Document Type: Article
L3 - 10.1006/fmic.2001.0460
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ER -
TY - JOUR
AU - Van Campen, Luann E.
AU - Murphy, William J.
AU - Franks, John R.
AU - Mathias, Patricia I.
AU - Toraason, Mark A.
T1 - Oxidative DNA damage is associated with intense noise exposure in the rat
JO - Hearing Research
JF - Hearing Research
Y1 - 2002/02//
VL - 164
IS - 1/2
M3 - Article
SP - 29
SN - 03785955
AB - Increasing evidence suggests that noise-induced hearing loss may be reduced or prevented with antioxidant therapy. Biochemical markers of reactive oxygen species (ROS)-induced damage can help elucidate possible treatment timing constraints. This study examined the time course of ROS damage following a 2-h, broad-band noise exposure resulting in permanent threshold shift in 35 Long–Evans rats. Cochlea, brain, liver, serum and urine were analyzed at 1, 3, 8, 72, and 672 h (28 days) after exposure. Oxidative DNA damage was assessed by measuring 8-hydroxy-2′-deoxyguanosine (8OHdG) by high performance liquid chromatography with electrochemical detection. Lipid peroxidation was measured via the thiobarbituric acid-reactive substances (TBARS) colorimetric assay for detection of aldehydes (e.g., malondialdehyde). Auditory brainstem response and distortion product otoacoustic emission thresholds showed progressive elevation for the 3- and 8-h groups, then notable recovery for the 72-h group, and some worsening for the 672-h group. 8OHdG was significantly elevated in cochlea in the 8-h group, and in brain and liver for the 72-h group. TBARS were significantly elevated in serum for the 72-h group. Based upon oxidative DNA damage present in cochlea following intense noise, we postulate that the first 8 h following exposure might be a critical period for antioxidant treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hearing Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOISE-induced deafness
KW - ANTIOXIDANTS
KW - BIOCHEMICAL markers
KW - 2dG, guanosine base
KW - 8OHdG, 8-hydroxy-2′-deoxyguanosine
KW - ABR, auditory brainstem response
KW - DPOAE, distortion product otoacoustic emission
KW - HPLC-EC, high performance liquid chromatography with electrochemical detection
KW - MDA, malondialdehyde
KW - PTS, permanent threshold shift
KW - ROS, reactive oxygen species
KW - TBARS, thiobarbituric acid-reactive substances
KW - TDT, Tucker-Davis Technologies
KW - Tris, Tris(hydroxymethyl)aminomethane
KW - TTS, temporary threshold shift
N1 - Accession Number: 7779282; Van Campen, Luann E. 1; Email Address: vancampen_l_e@lilly.com Murphy, William J. 1 Franks, John R. 1 Mathias, Patricia I. 2 Toraason, Mark A. 2; Affiliation: 1: Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH, 45226, USA 2: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH, 45226, USA; Source Info: Feb2002, Vol. 164 Issue 1/2, p29; Subject Term: NOISE-induced deafness; Subject Term: ANTIOXIDANTS; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: 2dG, guanosine base; Author-Supplied Keyword: 8OHdG, 8-hydroxy-2′-deoxyguanosine; Author-Supplied Keyword: ABR, auditory brainstem response; Author-Supplied Keyword: DPOAE, distortion product otoacoustic emission; Author-Supplied Keyword: HPLC-EC, high performance liquid chromatography with electrochemical detection; Author-Supplied Keyword: MDA, malondialdehyde; Author-Supplied Keyword: PTS, permanent threshold shift; Author-Supplied Keyword: ROS, reactive oxygen species; Author-Supplied Keyword: TBARS, thiobarbituric acid-reactive substances; Author-Supplied Keyword: TDT, Tucker-Davis Technologies; Author-Supplied Keyword: Tris, Tris(hydroxymethyl)aminomethane; Author-Supplied Keyword: TTS, temporary threshold shift; Number of Pages: 10p; Document Type: Article
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ER -
TY - JOUR
AU - Kozel, Peter J.
AU - Davis, Rickie R.
AU - Krieg, Edward F.
AU - Shull, Gary E.
AU - Erway, Lawrence C.
T1 - Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice
JO - Hearing Research
JF - Hearing Research
Y1 - 2002/02//
VL - 164
IS - 1/2
M3 - Article
SP - 231
SN - 03785955
AB - Susceptibility to noise-induced hearing loss (NIHL) is poorly understood at the genetic level. Mice homozygous for a null mutation in the plasma membrane Ca2+-ATPase isoform 2 (PMCA2) gene are deaf (Kozel et al., 1998). PMCA2 is expressed on outer hair cell stereocilia (Furuta et al., 1998). Fridberger et al. (1998) observed that the outer hair cell cytoplasmic Ca2+ concentration rises following acoustic overstimulation. We hypothesized that Pmca2+/− mice may be more susceptible to NIHL. Since the auditory brainstem response (ABR) thresholds of Pmca2+/− mice vary with the presence of a modifier locus (Noben-Trauth et al., 1997), Pmca2+/− mice were outcrossed to normal hearing CAST/Ei mice. The pre-exposure ABR thresholds of the resulting Pmca2+/+ and Pmca2+/− siblings were indistinguishable. Groups of these mice were exposed to varying intensities of broadband noise, and ABR threshold shifts were calculated. Fifteen days following an 8 h, 113 dB noise exposure, the Pmca2+/− mice displayed significant (P≤0.0007) permanent threshold shifts at 16 and 32 kHz that were 15 or 25 dB greater than those observed in Pmca2+/+ littermates. Pmca2 may be the first gene with a known mutated protein product that confers increased susceptibility to NIHL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hearing Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL membranes
KW - AUDITORY evoked response
KW - BRAIN stem
KW - −
KW - +, the wild-type allele
KW - +/−, heterozygous for wild-type and null alleles
KW - +/+, homozygous for the wild-type alleles
KW - , the knocked out (null) allele
KW - /−, homozygous for null alleles
KW - ABR, auditory brainstem response
KW - AHL, age-related hearing loss
KW - Ahl, the age-related hearing loss allele
KW - NIHL, noise-induced hearing loss
KW - PMCA2, plasma membrane calcium ATPase isoform 2
N1 - Accession Number: 7779301; Kozel, Peter J. 1 Davis, Rickie R. 2,3; Email Address: rrd1@cdc.gov Krieg, Edward F. 4 Shull, Gary E. 1 Erway, Lawrence C. 2; Affiliation: 1: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA 2: Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA 3: Hearing Loss Prevention Section, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 4: Monitoring Research and Statistics Activity, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Feb2002, Vol. 164 Issue 1/2, p231; Subject Term: CELL membranes; Subject Term: AUDITORY evoked response; Subject Term: BRAIN stem; Author-Supplied Keyword: −; Author-Supplied Keyword: +, the wild-type allele; Author-Supplied Keyword: +/−, heterozygous for wild-type and null alleles; Author-Supplied Keyword: +/+, homozygous for the wild-type alleles; Author-Supplied Keyword: , the knocked out (null) allele; Author-Supplied Keyword: /−, homozygous for null alleles; Author-Supplied Keyword: ABR, auditory brainstem response; Author-Supplied Keyword: AHL, age-related hearing loss; Author-Supplied Keyword: Ahl, the age-related hearing loss allele; Author-Supplied Keyword: NIHL, noise-induced hearing loss; Author-Supplied Keyword: PMCA2, plasma membrane calcium ATPase isoform 2; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Y
AU - Brackett, R.E
AU - Chen, J
AU - Beuchat, L.R
T1 - Mild heat treatment of lettuce enhances growth of Listeria monocytogenes during subsequent storage at 5°C or 15°C.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2002/02//
VL - 92
IS - 2
M3 - Article
SP - 269
EP - 275
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: The objective of this study was to determine the influence of mild heat treatment, storage temperature and storage time on the survival and growth of Listeria monocytogenes inoculated onto cut iceberg lettuce leaves. Methods and Results: Before or after inoculation with L. monocytogenes , cut iceberg lettuce leaves were dipped in water (20 or 50°C), containing or not 20 mg l–1 chlorine, for 90 s, then stored at 5°C for up to 18 days or 15°C for up to 7 days. The presence of 20 mg l–1 chlorine in the treatment water did not significantly (α=0·05) affect populations of the pathogen, regardless of other test parameters. The population of L. monocytogenes on lettuce treated at 50°C steadily increased throughout storage at 5°C for up to 18 days. At day 10 and thereafter, populations were 1·7–2·3 log10 cfu g–1 higher on lettuce treated at 50°C after inoculation compared with untreated lettuce or lettuce treated at 20°C, regardless of chlorine treatment. The population of L. monocytogenes increased rapidly on lettuce stored at 15°C. At 2 and 4 days, significantly higher populations were detected on lettuce that had been treated at 50°C, compared with respective samples that had been treated at 20°C, regardless of inoculation before or after treatment, or the presence of 20 mg l–1 chlorine in the treatment water. Conclusions: The results clearly demonstrated that mild heat treatment of cut lettuce leaves enhances the growth of L. monocytogenes during subsequent storage at 5 or 15°C. Significance and Impact of the Study: Mild heat treatment of cut lettuce may result in a prolonged shelf life as a result of delaying the development of brown discoloration. However, heat treatment also facilitates the growth of L. monocytogenes during storage at refrigeration temperature, thereby increasing the potential... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - TEMPERATURE
N1 - Accession Number: 5920137; Li, Y 1 Brackett, R.E 1,2 Chen, J 1 Beuchat, L.R 1; Affiliation: 1: Center for Food Safety and Department of Food Science and Technology, University of Georgia, USA, 2: Office of Plant and Dairy Foods and Beverages, US Food and Drug Administration, Washington, D.C., USA; Source Info: Feb2002, Vol. 92 Issue 2, p269; Subject Term: LISTERIA monocytogenes; Subject Term: TEMPERATURE; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1046/j.1365-2672.2002.01530.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Satcher, David
AU - Thompson, Tommy G
AU - Koplan, Jeffrey P
T1 - Women and smoking: a report of the Surgeon General.
JO - Nicotine & Tobacco Research
JF - Nicotine & Tobacco Research
Y1 - 2002/02//
VL - 4
IS - 1
M3 - journal article
SP - 7
EP - 20
SN - 14622203
KW - HEALTH promotion
KW - MEDICAL policy
KW - RESEARCH -- Finance
KW - SMOKING
KW - SMOKING cessation
KW - WOMEN -- Health
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 115881820; Satcher, David 1 Thompson, Tommy G Koplan, Jeffrey P; Affiliation: 1: Office of the Surgeon General, Washington DC, USA; Source Info: Feb2002, Vol. 4 Issue 1, p7; Subject Term: HEALTH promotion; Subject Term: MEDICAL policy; Subject Term: RESEARCH -- Finance; Subject Term: SMOKING; Subject Term: SMOKING cessation; Subject Term: WOMEN -- Health; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 14p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Farquhar, Cynthia M.
AU - Steiner, Claudia A.
T1 - Hysterectomy rates in the United States 1990–19971 1 The views expressed are those of the authors and not necessarily those of the Agency for Healthcare Research and Quality or the Commonwealth Fund of New York, its directors, officers, or staff.32±18 mutants/106 plaques; mean±SD) and α-hydroxytamoxifen (770±270 mutants/106 plaques) caused a significant increase in the mutant frequency of the lacI gene compared to solvent treated controls (10±10 mutants/106 plaques). 32P-Postlabeling analyses of liver DNA indicated three DNA adducts, one each from tamoxifen, N-desmethyltamoxifen, and N,N-didesmethyltamoxifen. Neither tamoxifen nor α-hydroxytamoxifen caused an increase in the mutant frequency in the lacI gene of the uterus or in the Hprt gene of spleen lymphocytes. These results suggest that induction of endometrial tumors in rats is not due to the genotoxicity of tamoxifen. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAMOXIFEN
KW - ESTROGEN antagonists
KW - RATS
KW - α
KW - -Hydroxytamoxifen
KW - Big Blue rats
KW - DNA adducts
KW - lacI
KW - Liver
KW - Mutagenesis
KW - Tamoxifen
KW - Uterus
N1 - Accession Number: 7742464; Gamboa da Costa, Gonçalo 1 Manjanatha, Mugimane G. 2 Matilde Marques, M. 1 Beland, Frederick A. 3; Email Address: fbeland@nctr.fda.gov; Affiliation: 1: Centro de Quımica Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, HFT-110, Jefferson, AR 72079, USA; Source Info: Feb2002, Vol. 176 Issue 1, p37; Subject Term: TAMOXIFEN; Subject Term: ESTROGEN antagonists; Subject Term: RATS; Author-Supplied Keyword: α; Author-Supplied Keyword: -Hydroxytamoxifen; Author-Supplied Keyword: Big Blue rats; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: lacI; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Mutagenesis; Author-Supplied Keyword: Tamoxifen; Author-Supplied Keyword: Uterus; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen, Susan S.
T1 - Regulatory and Drug Development Issues Related to Female Sexual Dysfunction.
JO - Journal of Sex & Marital Therapy
JF - Journal of Sex & Marital Therapy
Y1 - 2002/02/15/2002 Supplement 1
VL - 28
IS - 1
M3 - Article
SP - 11
EP - 16
PB - Routledge
SN - 0092623X
AB - Following the approval of sildenalfil for the treatment of erectile dysfunction, an increased awareness of and interest in female sexual dysfunction developed on the part of the academic and research communities as well as the pharmaceutical industry. This article will focus on regulatory issues related to the development of drug products to treat female sexual dysfunction and will describe a recently published drug development guidance document for this indication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Sex & Marital Therapy is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUAL dysfunction
KW - DRUG development
KW - IMPOTENCE
KW - HUMAN sexuality
KW - DRUGS
KW - CLINICAL trials
N1 - Accession Number: 6436362; Allen, Susan S. 1; Email Address: allensu@cder.fda.gov; Affiliation: 1: Division of Reproductive and Urologic Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Washington, D.C., USA.; Source Info: 2002 Supplement 1, Vol. 28 Issue 1, p11; Subject Term: SEXUAL dysfunction; Subject Term: DRUG development; Subject Term: IMPOTENCE; Subject Term: HUMAN sexuality; Subject Term: DRUGS; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/00926230252851159
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Sang-Yong
AU - Chang, Seung-Yeup
AU - Oh, O-Jin
AU - Yook, Chang-Soo
AU - Nohara, Toshihiro
T1 - nor-Oleanene type triterpene glycosides from the leaves of Acanthopanax japonicus
JO - Phytochemistry
JF - Phytochemistry
Y1 - 2002/02/15/
VL - 59
IS - 4
M3 - Article
SP - 379
SN - 00319422
KW - Acanjaposide A, B and C
KW - Acanthopanax japonicus
KW - Araliaceae
KW - Leaves
KW - nor-Oleanene glycoside
N1 - Accession Number: 8769403; Park, Sang-Yong 1; Email Address: none@gpo.kumamoto-u.ac.jp Chang, Seung-Yeup 2 Oh, O-Jin 3 Yook, Chang-Soo 4 Nohara, Toshihiro 1; Affiliation: 1: Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan 2: Korea Food and Drug Administration, 5 Nokbun-dong, Seoul 122-704, South Korea 3: College of Pharmacy, Woosuk University, Samrye, Wanju-gun, Churabuk-do 565-701, South Korea 4: College of Pharmacy, Kyung-Hee University, 1 Hoegi-dong, Seoul 132-702, South Korea; Source Info: Feb2002, Vol. 59 Issue 4, p379; Author-Supplied Keyword: Acanjaposide A, B and C; Author-Supplied Keyword: Acanthopanax japonicus; Author-Supplied Keyword: Araliaceae; Author-Supplied Keyword: Leaves; Author-Supplied Keyword: nor-Oleanene glycoside; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lathrop, Sarah L.
AU - Ball, Robert
AU - Haber, Penina
AU - Mootrey, Gina T.
AU - Braun, M. Miles
AU - Shadomy, Sean V.
AU - Ellenberg, Susan S.
AU - Chen, Robert T.
AU - Hayes, Edward B.
T1 - Adverse event reports following vaccination for Lyme disease: December 1998–July 2000
JO - Vaccine
JF - Vaccine
Y1 - 2002/02/22/
VL - 20
IS - 11/12
M3 - Article
SP - 1603
SN - 0264410X
AB - Context: The vaccine adverse event reporting system (VAERS) monitors vaccine safety post-licensure. Although events reported to VAERS are not necessarily causally associated with vaccination, VAERS reports can be used to identify possible safety concerns that occur at too low a rate to have been identified prior to licensure.Objective: To evaluate adverse events following Lyme disease vaccination reported to VAERS during the first 19 months of the vaccine’s licensure.Design, setting, and participants: Analysis of all VAERS reports of adverse events following vaccination for Lyme disease in the US from 28 December 1998 to 31 July 2000.Main outcome measure: We evaluated reported adverse events for unexpected patterns in age, gender, time to onset, dose number, and clinical characteristics and compared them to adverse events observed in clinical trials of this vaccine.Results: Over 1,400,000 doses were distributed and 905 adverse events were reported to VAERS, 440 in men and 404 in women, with ages ranging from 10 to 82 years. The majority (56%) of adverse events occurred after administration of the first dose. The most frequently reported adverse events were arthralgia (250), myalgia (195), and pain (157). There were 59 reports coded as arthritis, 34 as arthrosis, 9 as rheumatoid arthritis, and 12 as facial paralysis. Sixty-six (7.4%) events were classified as serious, involving life-threatening illness, hospitalization, prolongation of hospitalization, persistent or significant disability/incapacity, or death. Twenty-two hypersensitivity reactions were reported.Conclusions: Based on reporting to VAERS, we did not detect unexpected or unusual patterns of reported adverse events following Lyme disease vaccine administration, other than hypersensitivity reactions, compared with adverse events observed in clinical trials. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - LYME disease
KW - Adverse events
KW - Lyme disease
KW - Lyme vaccine
KW - Major histocompatibility complex
KW - Safety
KW - Vaccine adverse event reporting system
N1 - Accession Number: 7756061; Lathrop, Sarah L. 1 Ball, Robert 2 Haber, Penina 3 Mootrey, Gina T. 3 Braun, M. Miles 2 Shadomy, Sean V. 2 Ellenberg, Susan S. 2 Chen, Robert T. 3 Hayes, Edward B. 4; Email Address: ebh2@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention, Epidemic Intelligence Service, Atlanta, GA 30333, USA 2: Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, MD 20852, USA 3: Centers for Disease Control and Prevention, National Immunization Program, Atlanta, GA 30333, USA 4: Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, CO 80522, USA; Source Info: Feb2002, Vol. 20 Issue 11/12, p1603; Subject Term: VACCINATION; Subject Term: LYME disease; Author-Supplied Keyword: Adverse events; Author-Supplied Keyword: Lyme disease; Author-Supplied Keyword: Lyme vaccine; Author-Supplied Keyword: Major histocompatibility complex; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Vaccine adverse event reporting system; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, I.P.
AU - James, S. Jill
T1 - Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/02/25/
VL - 176
IS - 2
M3 - Article
SP - 169
SN - 03043835
AB - Functional inactivation of tumor suppressor genes during tumor progression has been shown to occur by either coding region mutation or promoter region methylation. Because of the functional equivalence of these two mechanisms, loss of tumor suppressor function generally occurs by one or the other mechanism, but rarely by both. Aberrant de novo methylation in most tumor suppressor promoter regions is found within CpG islands that occur near the transcription start site. The p53 promoter region is unique in that it does not contain a CpG island and therefore it is possible that methylation at critical CpG sites may be more important in gene silencing than total CpG methylation density. Other than site-specific aflatoxin B1-induced mutations, p53 coding region mutations are not frequently observed in most human primary hepatocellular carcinomas. In the present study, paired samples of human primary liver carcinoma and uninvolved tissue obtained from the same individual were evaluated for site-specific p53 promoter methylation status by methylation sensitive single nucleotide primer extension (Ms-SNuPE) and also for coding region mutations using polymerase chain reaction (PCR)- single strand conformation polymorphism (SSCP). The methylation pattern in the uninvolved tissue was variable at specific CpG sites, whereas the same sites had become highly methylated in tumor tissue from the same individual. Associated with de novo methylation, the level of p53 mRNA was significantly reduced in the tumor DNA relative to the uninvolved tissue DNA. None of the samples exhibited coding region mutations. Given that p53 mutations are rare in primary human liver tumors, these data suggest that transcriptional repression by p53 promoter methylation may contribute to tumor progression. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Cancer
KW - ANTIONCOGENES
KW - MUTATION (Biology)
KW - DNA methylation
KW - Gene expression
KW - Hepatocellular carcinoma
KW - Human
KW - Mutation
KW - p53 promoter
N1 - Accession Number: 7745388; Pogribny, I.P. 1 James, S. Jill 1; Email Address: jjames@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Feb2002, Vol. 176 Issue 2, p169; Subject Term: LIVER -- Cancer; Subject Term: ANTIONCOGENES; Subject Term: MUTATION (Biology); Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Hepatocellular carcinoma; Author-Supplied Keyword: Human; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: p53 promoter; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frazier-Jessen, Michelle R.
AU - Thompson, Cynthia D.
AU - Brown, Robert
AU - Rawat, Rashmi
AU - Nordan, Richard P.
AU - Feldman, Gerald M.
T1 - NF-κB elements contribute to junB inducibility by lipopolysaccharide in the murine macrophage cell line RAW264.7
JO - FEBS Letters
JF - FEBS Letters
Y1 - 2002/02/27/
VL - 513
IS - 2/3
M3 - Article
SP - 203
SN - 00145793
AB - Macrophages respond to bacterial lipopolysaccharide (LPS) by activating latent cis-acting factors that initiate transcription of immediate early genes. One such immediate early gene, junB, is induced by LPS in macrophages within 30 min. To identify elements that mediate the induction of junB by LPS, upstream and downstream sequences flanking the junB gene were examined by transient expression in the RAW264.7 murine macrophage cell line using a luciferase reporter gene vector containing the junB minimal promoter. A >10-fold enhancement was associated with a 222 bp region downstream of the junB promoter in response to LPS. Transient reporter assays demonstrated that multiple nuclear factor (NF) κB sites are required for inducibility of junB by LPS in RAW264.7 cells. Electrophoretic mobility shift assays confirmed binding of LPS-induced nuclear proteins included p50/p65 heterodimers at these NF-κB sites. [Copyright &y& Elsevier]
AB - Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NF-kappa B (DNA-binding protein)
KW - MACROPHAGES
KW - junB
KW - Lipopolysaccharide
KW - Macrophage
KW - Nuclear factor κB
N1 - Accession Number: 7770148; Frazier-Jessen, Michelle R. 1; Email Address: jessen@cber.fda.gov Thompson, Cynthia D. 1 Brown, Robert 2 Rawat, Rashmi 1 Nordan, Richard P. 1 Feldman, Gerald M. 1; Affiliation: 1: Laboratory of Immunobiology, Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-564, Building 29A, Room 3C22, 29 Lincoln Drive, Bethesda, MD 20892, USA 2: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA; Source Info: Feb2002, Vol. 513 Issue 2/3, p203; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: MACROPHAGES; Author-Supplied Keyword: junB; Author-Supplied Keyword: Lipopolysaccharide; Author-Supplied Keyword: Macrophage; Author-Supplied Keyword: Nuclear factor κB; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Streicher, Robert P.
AU - Reh, Christopher M.
AU - Key-Schwartz, Rosa
AU - Schlecht, Paul C.
AU - Cassinelli, Mary Ellen
AU - O'Connor, Paula Fey
T1 - Selecting Isocyanate Sampling and Analytical Methods.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/03//
VL - 17
IS - 3
M3 - Article
SP - 157
EP - 162
SN - 1047322X
AB - Discusses the sampling and analytical methods of determining isocyanate-containing compounds exposure. Automobile painting and mining; Exposure standards.
KW - ISOCYANATES
KW - INDUSTRIAL hygiene
KW - HEALTH
N1 - Accession Number: 6411269; Streicher, Robert P. 1 Reh, Christopher M. 2 Key-Schwartz, Rosa 1 Schlecht, Paul C. 1 Cassinelli, Mary Ellen 1 O'Connor, Paula Fey 1; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998 2: Gillette Medical Evaluation Laboratories, 37 A Street, Needham, MA 02492-9210; Source Info: Mar2002, Vol. 17 Issue 3, p157; Subject Term: ISOCYANATES; Subject Term: INDUSTRIAL hygiene; Subject Term: HEALTH; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/104732202753438234
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linch, Kenneth D.
T1 - Respirable Concrete Dust—Silicosis Hazard in the Construction Industry.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/03//
VL - 17
IS - 3
M3 - Article
SP - 209
EP - 221
SN - 1047322X
AB - Concrete is an extremely important part of the infrastructure of modern life and must be replaced as it ages. Many of the methods of removing, repairing, or altering existing concrete structures have the potential for producing vast quantities of respirable dust. Since crystalline silica in the form of quartz is a major component of concrete, airborne respirable quartz dust may be produced during construction work involving the disturbance of concrete, thereby producing a silicosis hazard for exposed workers. Silicosis is a debilitating and sometimes fatal lung disease resulting from breathing microscopic particles of crystalline silica. Between 1992 and 1998, the National Institute for Occupational Safety and Health (NIOSH) made visits to construction projects where concrete was being mechanically disturbed in order to obtain data concerning respirable crystalline silica dust exposures. The construction activities studied included: abrasive blasting, concrete pavement sawing and drilling, and asphalt/concrete milling. Air samples of respirable dust were obtained using 10-mm nylon cyclone pre-separators, 37-mm polyvinyl chloride (PVC) filters, and constant-flow pumps calibrated at 1.7 L/min. In addition, high-volume respirable dust samples were obtained on 37-mm PVC filters using ½″ metal cyclones (Sensidyne model 18) and constant-flow pumps calibrated at 9.0 L/min. Air sample analysis included total weight gain by gravimetric analysis according to NIOSH Analytical Method 600 and respirable crystalline silica (quartz and cristobalite) using x-ray diffraction, as per NIOSH Analytical Method 7500. For abrasive blasting of concrete structures, the respirable crystalline silica (quartz) concentration ranged up to 14.0 mg/m[sup 3] for a 96-minute sample resulting in an eight-hour time-weighted average (TWA) of 2.8 mg/m[sup 3]. For drilling concrete highway pavement the respirable quartz concentrations ranged up to 4.4 mg/m[sup 3] for a 358-minute sample, resulting in an eight-hour TWA of 3.3 mg/m[sup 3]. For concrete wall grinding during new building construction the respirable quartz measurements ranged up to 0.66 mg/m[sup 3] for a 191-minute sample, resulting in an eight-hour TWA of 0.26 mg/m[sup 3]. The air sampling results for concrete sawing ranged up to 14.0 mg/m[sup 3] for a 350-minute sample resulting in an eight-hour TWA of 10.0 mg/m[sup 3]. During the milling of asphalt from concrete highway pavement, the sampling indicated a respirable quartz concentration ranging up to 0.34 mg/m[sup 3] for a 504-minute sample, resulting in an eight-hour TWA of 0.36 mg/m[sup 3]. The results of this work indicate the potential for respirable quartz concentrations involving disturbance of concrete to range up to 280 times the NIOSH Recommended Exposure Limit (REL) of 0.05 mg/m[sup 3] assuming exposure for an eight- to ten-hour workday. Considering the aging of the concrete infrastructure in the United States, these results pose a challenge to all who have an interest in preventing silica exposures and the associated disease silicosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DUST
KW - CONCRETE construction industry
KW - HEALTH
KW - CONCRETE ABRASIVE BLASTING
KW - CONCRETE DRILLING
KW - CONCRETE DUST
KW - CONCRETE GRINDING
KW - CONCRETE MILLING
KW - CONCRETE SAWING
KW - Construction
KW - CONSTRUCTION DUST
KW - CRYSTALLINE SILICA DUST
KW - Silica dust
N1 - Accession Number: 6411274; Linch, Kenneth D. 1; Affiliation: 1: Division of Respiratory Disease Studies, Surveillance Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Mar2002, Vol. 17 Issue 3, p209; Subject Term: DUST; Subject Term: CONCRETE construction industry; Subject Term: HEALTH; Author-Supplied Keyword: CONCRETE ABRASIVE BLASTING; Author-Supplied Keyword: CONCRETE DRILLING; Author-Supplied Keyword: CONCRETE DUST; Author-Supplied Keyword: CONCRETE GRINDING; Author-Supplied Keyword: CONCRETE MILLING; Author-Supplied Keyword: CONCRETE SAWING; Author-Supplied Keyword: Construction; Author-Supplied Keyword: CONSTRUCTION DUST; Author-Supplied Keyword: CRYSTALLINE SILICA DUST; Author-Supplied Keyword: Silica dust; NAICS/Industry Codes: 238110 Poured Concrete Foundation and Structure Contractors; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/104732202753438298
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hung, Shirley
AU - Morrison, Donna Ruane
AU - Whittington, Leslie A
AU - Fein, Sara Beck
T1 - Prepartum Work, Job Characteristics, and Risk of Cesarean Delivery.
JO - Birth: Issues in Perinatal Care
JF - Birth: Issues in Perinatal Care
Y1 - 2002/03//
VL - 29
IS - 1
M3 - Article
SP - 10
EP - 17
PB - Wiley-Blackwell
SN - 07307659
AB - Background: Reducing the rate of cesarean deliveries in the United States is a high priority among public health officials and members of the medical community. Many factors known to contribute to an individual woman's risk of having a cesarean rather than a vaginal delivery are not readily altered by public policy intervention. In this study we explored the effects on type of delivery of prepartum work practices, a category of factors that has a potential to affect the likelihood of cesarean delivery and to be amenable to change. Methods: Data are from U.S. Food and Drug Administration's Infant Feeding Practices Study, using questions on mail surveys administered prenatally and at 1 month postpartum. The sample comprised 1194 women who worked during pregnancy. The outcome measure is type of delivery. Predictor variables are characteristics of prepartum work: how far into their pregnancy the women work, number of hours worked, and occupation. Results: For most women, maintaining employment through the third trimester, working long hours, and working in certain occupations are not independently associated with the odds of having a cesarean delivery. However, we found marginally significant evidence that those women who worked more than 40 hours a week in a sales job were more likely to have cesarean deliveries than women who worked in other occupations. Conversely, women working part-time in sales jobs were less likely to have a cesarean delivery. Conclusion: This study provides evidence that prenatal work does not substantially increase the probability of having a cesarean delivery in most occupational categories. (BIRTH 29:1 March 2002). [ABSTRACT FROM AUTHOR]
AB - Copyright of Birth: Issues in Perinatal Care is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CESAREAN section
KW - OBSTETRICS -- Surgery
N1 - Accession Number: 6147992; Hung, Shirley 1 Morrison, Donna Ruane 2 Whittington, Leslie A 2 Fein, Sara Beck 3; Affiliation: 1: Shirley Hung is from Cable News Network, Washington, DC. 2: Donna Morrison and Leslie Whittington are from the Georgetown Public Policy Institute, Georgetown University, Washington, DC. 3: Sarah Fein is from Division of Market Studies, Food and Drug Administration, U.S. Department of Health and Human Services, College Park, Maryland.; Source Info: Mar2002, Vol. 29 Issue 1, p10; Subject Term: CESAREAN section; Subject Term: OBSTETRICS -- Surgery; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1523-536X.2002.00150.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Voss, Kenneth A.
AU - Howard, Paul C.
AU - Riley, Ronald T.
AU - Sharma, Raghubir P.
AU - Bucci, Thomas J.
AU - Lorentzen, Ronald J.
T1 - Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides)
JO - Cancer Detection & Prevention
JF - Cancer Detection & Prevention
Y1 - 2002/03//
VL - 26
IS - 1
M3 - Article
SP - 1
SN - 0361090X
AB - Fumonisins are fungal metabolites and suspected human carcinogens. They inhibit ceramide synthase in vitro, enhance tumor necrosis factor α (TNFα) production, and cause apoptosis. Fumonisin B1 (FB1) was fed to rats and mice for 2 years or, in separate studies, given to rats or mice for up to 4 weeks. Kidney tubule adenomas and carcinomas were found in male rats fed ≥50 ppm, whereas liver adenomas and carcinomas were found in female mice fed ≥50 ppm for 2 years. In the short-term studies, increases in tissue concentration of the ceramide synthase substrate sphinganine (Sa) and the Sa to sphingosine (So) ratio were correlated with apoptosis. Further, hepatotoxicity was ameliorated in mice lacking either the TNFR1 or the TNFR2 TNFα receptors. Thus, FB1 was carcinogenic to rodents and the findings support the hypothesis that disrupted sphingolipid metabolism and TNFα play important roles in its mode of action. [Copyright &y& Elsevier]
AB - Copyright of Cancer Detection & Prevention is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FUMONISINS
KW - CARCINOGENS
KW - TUMORS
KW - MICE
KW - SPHINGOSINE
KW - Carcinogenicity
KW - Fumonisin B1
KW - Fusarium moniliforme (= F. verticillioides)
KW - Sphingolipids
KW - Tumor necrosis factor α
N1 - Accession Number: 7791526; Voss, Kenneth A. 1; Email Address: kvoss@saa.ars.usda.gov Howard, Paul C. 2 Riley, Ronald T. 1 Sharma, Raghubir P. 3 Bucci, Thomas J. 4 Lorentzen, Ronald J. 5; Affiliation: 1: Toxicology and Mycotoxin Research Unit, Agricultural Research Service, Richard B. Russell Agricultural Research Center, US Department of Agriculture, Athens, GA 30604-5677, USA 2: Biochemical Carcinogenesis, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA 3: Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA 4: Experimental Pathology Associates, Jefferson, AR 72079, USA 5: Center for Food Safety and Nutrition, US Food and Drug Administration, Washington, DC 20204, USA; Source Info: Mar2002, Vol. 26 Issue 1, p1; Subject Term: FUMONISINS; Subject Term: CARCINOGENS; Subject Term: TUMORS; Subject Term: MICE; Subject Term: SPHINGOSINE; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Fumonisin B1; Author-Supplied Keyword: Fusarium moniliforme (= F. verticillioides); Author-Supplied Keyword: Sphingolipids; Author-Supplied Keyword: Tumor necrosis factor α; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimmer, Anthony T.
AU - Baron, Paul A.
AU - Biswas, Pratim
T1 - The influence of operating parameters on number-weighted aerosol size distribution generated from a gas metal arc welding process
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2002/03//
VL - 33
IS - 3
M3 - Article
SP - 519
SN - 00218502
AB - In light of recent research on the potential health problems associated with sub-micrometer aerosols, a study was conducted to determine the effect that droplet mass transfer mode, shield gas composition, and welding spatter had upon the aerosols generated from a Gas Metal Arc Welding (GMAW) Operation. The results revealed that the sub-micrometer aerosols produced during spray transfer resulted in markedly higher concentrations of nucleated particles than those produced during globular transfer. This probably resulted from a larger droplet surface area for vaporization of metallic species. The shield gas experiments results revealed that as the percentage of carbon dioxide increased the number of nucleated particles also increased. It appears that oxygen may have facilitated chemical reactions with the alloy constituents, thereby increasing the mass transfer rate from the evaporating metal droplets in the plasma. Finally, an attempt to characterize the spatter aerosol revealed a distinct particle size distribution with a mode particle diameter of 6.8 μm . This particle size distribution appeared to be independent of shield gas composition, and the particle number concentration was significantly smaller than the sub-micrometer aerosols formed during the GMAW process (i.e., two-orders of magnitude smaller when weighted by particle mass). [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - HEALTH risk assessment
KW - MASS transfer
KW - Arc
KW - Fumes
KW - Spatter
KW - Welding
N1 - Accession Number: 7743884; Zimmer, Anthony T. 1; Email Address: atz0@cdc.gov Baron, Paul A. 1 Biswas, Pratim 2; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Washington University, Departments of Chemical and Civil Engineering, One Brookings Drive, Campus Box 1180, St. Louis, MO 63130-4899, USA; Source Info: Mar2002, Vol. 33 Issue 3, p519; Subject Term: AEROSOLS (Sprays); Subject Term: HEALTH risk assessment; Subject Term: MASS transfer; Author-Supplied Keyword: Arc; Author-Supplied Keyword: Fumes; Author-Supplied Keyword: Spatter; Author-Supplied Keyword: Welding; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Mingjie
AU - Li, Xingxiang
AU - Pang, Xiaowu
AU - Ding, Linna
AU - Wood, Owen
AU - Clouse, Kathleen A.
AU - Hewlett, Indira
AU - Dayton, Andrew I.
T1 - Bcl-2 Upregulation by HIV-1 Tat during Infection of Primary Human Macrophages in Culture.
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
Y1 - 2002/03//
VL - 9
IS - 2
M3 - Article
SP - 133
EP - 139
PB - BioMed Central
SN - 10217770
AB - The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is believed to significantly contribute to their ability to serve as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptotic pathways can render them susceptible to apoptosis. Here we report that HIV-1[sub BAL ] infection of primary human monocyte-derived macrophages (MDM) upregulates the mRNA and protein levels of the anti-apoptic gene, Bcl-2. Furthermore, this upregulation can be quantitatively mimicked by treating MDM with soluble HIV-1 Tat-86 protein. These results suggest that in infecting cells of the monocyte/macrophage lineage, HIV-1 may be benefiting from additional protection against apoptosis caused by specific upregulation of cellular anti-apoptotic genes.Copyright © 2002 National Science Council, ROC and S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomedical Science is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - MONOCYTES
KW - MACROPHAGES
KW - APOPTOSIS
KW - HIV (Viruses)
KW - MITOCHONDRIAL membranes
KW - Apoptosis
KW - Bcl-2
KW - HIV
KW - HIV-1
KW - Macrophage
KW - Tat
N1 - Accession Number: 11372275; Zhang, Mingjie 1 Li, Xingxiang 1 Pang, Xiaowu 1 Ding, Linna 1 Wood, Owen 1 Clouse, Kathleen A. 2 Hewlett, Indira 1 Dayton, Andrew I. 1; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research 2: Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, Md., USA; Source Info: 2002, Vol. 9 Issue 2, p133; Subject Term: CELLS; Subject Term: MONOCYTES; Subject Term: MACROPHAGES; Subject Term: APOPTOSIS; Subject Term: HIV (Viruses); Subject Term: MITOCHONDRIAL membranes; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Bcl-2; Author-Supplied Keyword: HIV; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: Macrophage; Author-Supplied Keyword: Tat; Number of Pages: 7p; Document Type: Article
L3 - 10.1159/000048209
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirby, James B.
T1 - The Influence of Parental Separation on Smoking Initiation in Adolescents.
JO - Journal of Health & Social Behavior
JF - Journal of Health & Social Behavior
Y1 - 2002/03//
VL - 43
IS - 1
M3 - Article
SP - 56
EP - 71
SN - 00221465
AB - Most adult smokers start smoking when they are adolescents and, the prevalence of smoking declines less than other unhealthy behaviors as people mature. Understanding why adolescents start smoking is, therefore, key to developing effective policy aimed at lowering the prevalence of smoking in both children and adults. In this study, I suggest that parental separation is one possible risk factor for smoking initiation. I use a nationally representative sample of American adolescents interviewed at two points in time to examine the influence of parental separation on smoking initiation. Two questions are addressed. First, is there a relationship between parental separation and the likelihood that an adolescent will initiate smoking? Second, if there is a relationship, through what factors does parental separation operate to influence the initiation of smoking in adolescents? My findings suggest that parental separation increases the likelihood that adolescents will start smoking. It does so in part by raising depressive symptoms and rebelliousness in adolescents. Despite the significance of these indirect effects, however, the bulk of the effect of parental separation on smoking initiation is direct. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - CHILDREN
KW - ADULTS
KW - TEENAGERS
KW - SEPARATION (Law)
KW - HEALTH
N1 - Accession Number: 6645222; Kirby, James B. 1; Email Address: jkirby@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Mar2002, Vol. 43 Issue 1, p56; Subject Term: SMOKING; Subject Term: CHILDREN; Subject Term: ADULTS; Subject Term: TEENAGERS; Subject Term: SEPARATION (Law); Subject Term: HEALTH; Number of Pages: 16p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gursel, I.
AU - Yagmurlu, F.
AU - Korkusuz, F.
AU - Hasirci, V.
T1 - In vitro antibiotic release from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) rods.
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
Y1 - 2002/03//Mar/Apr2002
VL - 19
IS - 2
M3 - Article
SP - 153
EP - 164
PB - Taylor & Francis Ltd
SN - 02652048
AB - Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may not be effective due to damaged vasculature. In this study, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) rods containing 7, 14 and 22% (mol) 3-hydroxyvalerate were loaded with sulbactam:cefoperazone or gentamicin[sup ®], and their antibiotic release behaviours were studied under in vitro conditions in physiological phosphate buffer at room temperature. The release patterns were representative of release from monolithic devices where a rapid early release phase is followed by a slower and prolonged release. With PHBV 22 rods, the latter phase continued for 2 months. This duration is critical because a proper antibiotic therapy of IRO requires the minimal effective concentration for at least 6 weeks. After in vitro release, voids with sharp edges were detected on the rods, indicating that the drug crystals dissolved but the polymer did not undergo erosion within this test period. Changing the polymer:drug ratio from 2:1 to 20:1 substantially decreased the drug release rate. A change of polymer type, however, did not lead to any detectable changes in the release patterns. Gentamicin[sup ®] release also followed a similar pattern, except that the concentration of the drug in the release medium exhibited a decrease after long release periods, indicating degradation (or decomposition) of the antibiotic in the release medium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Microencapsulation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBIOTICS
KW - GENTAMICIN
KW - Controlled drug delivery
KW - ENCAPSULATION
KW - Osteomyelitis
KW - POLYHYDROXYBUTYRATE
KW - SULPERAZONE
N1 - Accession Number: 5942403; Gursel, I. 1 Yagmurlu, F. 2 Korkusuz, F. 3 Hasirci, V. 4; Affiliation: 1: Centre for Biological Research, Food and Drug Administration, Laboratory of Retroviral Immunology, NIH Campus, Bethesda MD, 20892, USA 2: Numune State Hospital, 3rd Department of Orthopaedic Surgery and Traumatology, 06100 Sihhiye, Ankara, Turkey 3: Middle East Technical University, Medical Centre 06531 Ankara, Turkey 4: Middle East Technical University, Department of Biological Sciences, Biotechnology Research Unit, 06531 Ankara, Turkey; Source Info: Mar/Apr2002, Vol. 19 Issue 2, p153; Subject Term: ANTIBIOTICS; Subject Term: GENTAMICIN; Author-Supplied Keyword: Controlled drug delivery; Author-Supplied Keyword: ENCAPSULATION; Author-Supplied Keyword: Osteomyelitis; Author-Supplied Keyword: POLYHYDROXYBUTYRATE; Author-Supplied Keyword: SULPERAZONE; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/02652040110065413
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Megivern, Deborah
T1 - Evaluation of a Unique Oral Contraceptive in the Treatment of Premenstrual Dysphoric Disorder.
JO - Journal of Women's Health & Gender-Based Medicine
JF - Journal of Women's Health & Gender-Based Medicine
Y1 - 2002/03//
VL - 11
IS - 2
M3 - Article
SP - 95
EP - 96
PB - Mary Ann Liebert, Inc.
SN - 15246094
AB - Presents a letter to the editor about the oral contraceptive in the treatment of premenstrual dysphoric disorder.
KW - LETTERS to the editor
KW - CONTRACEPTIVE drugs
N1 - Accession Number: 6576125; Megivern, Deborah 1; Affiliation: 1: Washington University, Center for Mental Health Services Research, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130-4899.; Source Info: Mar2002, Vol. 11 Issue 2, p95; Subject Term: LETTERS to the editor; Subject Term: CONTRACEPTIVE drugs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: Article
L3 - 10.1089/152460902753645218
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaufman, G.E
AU - Myers, M.L
AU - Pass, C.L
AU - Bej, A.K
AU - Kaysner, C.A
T1 - Molecular analysis of Vibrio parahaemolyticus isolated from human patients and shellfish during US Pacific north-west outbreaks.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2002/03//
VL - 34
IS - 3
M3 - Article
SP - 155
EP - 161
PB - Wiley-Blackwell
SN - 02668254
AB - Aims: The objective of this study was to investigate the occurrence and distribution of haemolysin genes, plasmid profile, serogroup analysis and cellular urease activity for Vibrio parahaemolyticus isolates from infected human patients and oysters from the Pacific north-western United States between 1988 and 1997. Methods and Results: All of the clinical and environmental isolates tested in this study exhibited the presence of the thermolabile haemolysin gene, tl , confirming that all of the isolates were V. parahaemolyticus . Furthermore, the V. parahaemolyticus isolates that contained either the thermostable direct haemolysin gene, tdh, or the thermostable direct haemolysin-related gene, trh , or both, were also positive for urease. Isolates from infected human patients belong to serogroups O1 and O4, whereas, the isolates from oysters belong to serogroups O1, O4 and O5. These results suggest that the presence of a V. parahaemolyticus serogroup O1 and O4 could indicate the presence of a virulent strain of this pathogen. In this study, the presence of the haemolysin genes, serogroup profiles and urease production in V. parahaemolyticus isolated from human patients correlated with the oysters collected during the outbreaks. However, no significant correlation of the plasmid profiles was detected, based on their distribution and molecular weights, between V. parahaemolyticus isolated from infected human patients and from oysters collected during this outbreak. Conclusions, Significance and Impact of the Study: It is apparent from this study that the identification of the haemolysin genes by multiplex PCR amplification, in conjunction with serogroup analysis and urease production, can be used to monitor shellfish for the presence of potentially pathogenic strains of V. parahaemolyticus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Letters in Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOLYSIS & hemolysins
KW - VIBRIO
KW - SHELLFISH
N1 - Accession Number: 6528251; Kaufman, G.E 1 Myers, M.L 1 Pass, C.L 1 Bej, A.K 1 Kaysner, C.A 2; Affiliation: 1: Department of Biology, University of Alabama at Birmingham, USA, 2: US Food and Drug Administration, Seafood Products Research Center, Bothell, WA, USA; Source Info: Mar2002, Vol. 34 Issue 3, p155; Subject Term: HEMOLYSIS & hemolysins; Subject Term: VIBRIO; Subject Term: SHELLFISH; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 7p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1472-765x.2002.01076.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kogan, Michael D.
AU - Alexander, Greg R.
AU - Kotelchuck, Milton
AU - MacDorman, Marian F.
AU - Buekens, Pierre
AU - Papiernik, Emile
T1 - A Comparison of Risk Factors for Twin Preterm Birth in the United States Between 1981–82 and 1996–97.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2002/03//
VL - 6
IS - 1
M3 - Article
SP - 29
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objective : This paper examines risk factors for twin preterm birth in 1981–82 and 1996–97 in the United States in order to see if they have changed over time. Methods : We studied all U.S. twin births for the years examined (N = 346,567). Since the gestational age distributions for twins differs from singletons, the risk of preterm birth was examined at <33, 33–34, and 35–36 weeks. Logistic regression was used to examine the contributions of sociodemographic and obstetric factors at each period. Results : While the <33 week twin preterm rate rose 7% from 1981–82 to 1996–97, the 33–34-week rate rose 31%, and the 35–36-week rate rose 51%. Women with less education, teenagers, unmarried women, primiparas, and blacks were more likely to deliver preterm across all three preterm birth levels. However, the effect of these low socioeconomic status markers diminished over the study period. Additionally, the odds of preterm birth among blacks increased with earlier gestational ages. Women who had intensive prenatal care utilization as compared with less than adequate utilization were more likely to deliver preterm (35–36 weeks) in 1996–97 (odds ratio (OR) = 2.05) compared with 1981–82 (OR = 1.44). Smaller increases were noted for <33 and 33–34 weeks. Conclusions : Obstetric factors appear to be playing a greater role in the rise of twin preterm births at 35–36 weeks gestation. Temporal sociodemographic changes do not explain the rise in the preterm rate. Changing clinical practices may be having unintended consequences on the public health goals of reducing preterm and low birthweight rates in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTETRICS
KW - TWINS
KW - BIRTH weight
KW - PUBLIC health
KW - UNITED States
KW - obstetric practices
KW - preterm birth
KW - racial disparities
KW - twins
KW - United States
N1 - Accession Number: 11307887; Kogan, Michael D. 1; Email Address: mkogan@hrsa.gov Alexander, Greg R. 2 Kotelchuck, Milton 3 MacDorman, Marian F. 4 Buekens, Pierre 5 Papiernik, Emile 2,6; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: Department of Maternal and Child Health, University of Alabama at Birmingham, Birmingham, Alabama 3: Department of Maternal and Child Health, Boston University, Boston, Massachusetts 4: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 5: Department of Maternal and Child Health, University of North Carolina, Chapel Hill, North Carolina 6: Department of Obstetrics and Gynecology, University Rene Descartes, Paris, France; Source Info: Mar2002, Vol. 6 Issue 1, p29; Subject Term: OBSTETRICS; Subject Term: TWINS; Subject Term: BIRTH weight; Subject Term: PUBLIC health; Subject Term: UNITED States; Author-Supplied Keyword: obstetric practices; Author-Supplied Keyword: preterm birth; Author-Supplied Keyword: racial disparities; Author-Supplied Keyword: twins; Author-Supplied Keyword: United States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ge, Beilei
AU - Zhao, Shaohua
AU - Hall, Robert
AU - Meng, Jianghong
T1 - A PCR–ELISA for detecting Shiga toxin-producing Escherichia coli
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2002/03//
VL - 4
IS - 3
M3 - Article
SP - 285
SN - 12864579
AB - A sensitive and specific PCR–ELISA was developed to detect Escherichia coli O157:H7 and other Shiga toxin-producing E. coli (STEC) in food. The assay was based on the incorporation of digoxigenin-labeled dUTP and a biotin-labeled primer specific for Shiga toxin genes during PCR amplification. The labeled PCR products were bound to streptavidin-coated wells of a microtiter plate and detected by an ELISA. The specificity of the PCR was determined using 39 bacterial strains, including STEC, enteropathogenic E. coli, E. coli K12, and Salmonella. All of the STEC strains were positive, and non-STEC organisms were negative. The ELISA detecting system was able to increase the sensitivity of the PCR assay by up to 100-fold, compared with a conventional gel electrophoresis. The detection limit of the PCR–ELISA was 0.1–10 CFU dependent upon STEC serotypes, and genotypes of Shiga toxins. With the aid of a simple DNA extraction system, PrepMan, the PCR–ELISA was able to detect ca. 105 CFU of STEC per gram of ground beef without any culture enrichment. The entire procedure took about 6 h. Because of its microtiter plate format, PCR–ELISA is particularly suitable for large-scale screening and compatible with future automation. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - ENZYME-linked immunosorbent assay
KW - BACTERIAL toxins
KW - ELISA
KW - PCR
KW - Shiga toxin-producing E. coli
N1 - Accession Number: 7770941; Ge, Beilei 1 Zhao, Shaohua 1 Hall, Robert 2 Meng, Jianghong 1; Email Address: jm332@umail.umd.edu; Affiliation: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 200 C Street, SW Washington, DC 20204, USA; Source Info: Mar2002, Vol. 4 Issue 3, p285; Subject Term: POLYMERASE chain reaction; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: BACTERIAL toxins; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Shiga toxin-producing E. coli; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Suzanne M.
T1 - A role for p53 in the frequency and mechanism of mutation
JO - Mutation Research/Reviews in Mutation Research
JF - Mutation Research/Reviews in Mutation Research
Y1 - 2002/03//
VL - 511
IS - 1
M3 - Article
SP - 45
SN - 13835742
AB - The tumor suppressor protein, p53, is often referred to as the guardian of the genome. When p53 function is impaired, its ability to preserve genomic integrity is compromised. This may result in an increase in mutation on both a molecular and chromosomal level and contribute to the progression to a malignant phenotype. In order to study the effect of p53 function on the acquisition of mutation, in vitro and in vivo models have been developed in which both the frequency and mechanism of mutation can be analyzed. In human lymphoblastoid cells in which p53 function was impaired, both the spontaneous and induced mutant frequency increased at the autosomal thymidine kinase (TK) locus. The mutant frequency increased to a greater extent in cell lines in which p53 harbored a point mutation than in those lines in which a “null” mutation had been introduced by molecular targeting or by viral degradation indicating a possible “gain-of-function” associated with the mutant protein. Further, molecular analysis revealed that the loss of p53 function was associated with a greater tendency towards loss-of-heterozygosity (LOH) within the TK gene that was due to non-homologous recombination than that found in wild-type cells. Most data obtained from the in vivo models uses the LacI reporter gene that does not efficiently detect mutation that results in LOH. However, studies that have examined the effect of p53 status on mutation in the adenine phosphoribosyl transferase (APRT) gene in transgenic mice also suggest that loss of p53 function results in an increase in mutation resulting from non-homologous recombination. The results of these studies provide clear and convincing evidence that p53 plays a role in modulating the mutant frequency and the mechanism of mutation. In addition, the types of mutation that occur within the p53 gene are also of importance in determining the mutant frequency and the pathways leading to mutation. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Reviews in Mutation Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - P53 antioncogene
KW - MUTATION (Biology)
KW - Loss-of-function
KW - Mutant p53
KW - p53
KW - p53 knockout
N1 - Accession Number: 7770677; Morris, Suzanne M. 1; Email Address: smorris@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Mar2002, Vol. 511 Issue 1, p45; Subject Term: P53 antioncogene; Subject Term: MUTATION (Biology); Author-Supplied Keyword: Loss-of-function; Author-Supplied Keyword: Mutant p53; Author-Supplied Keyword: p53; Author-Supplied Keyword: p53 knockout; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Popke, E.J.
AU - Patton, R.
AU - Newport, G.D.
AU - Rushing, L.G.
AU - Fogle, C.M.
AU - Allen, R.R.
AU - Pearson, E.C.
AU - Hammond, T.G.
AU - Paule, M.G.
T1 - Assessing the potential toxicity of MK-801 and remacemide:: Chronic exposure in juvenile rhesus monkeys
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2002/03//
VL - 24
IS - 2
M3 - Article
SP - 193
SN - 08920362
AB - The present experiment examined the effects of chronic exposure to either 0.1 or 1.0 mg/kg MK-801 [a selective N-methyl-d-aspartate (NMDA) receptor antagonist] or 20.0 or 50.0 mg/kg remacemide (an NMDA receptor antagonist which also blocks fast sodium channels) in juvenile rhesus monkeys. Endpoints were monitored to provide a general index of subjects'' health and included measures of clinical chemistry, hematology, ophthalmology, spontaneous home-cage behavior, and peak drug plasma levels. In general, both drugs were well tolerated and produced no treatment-related effects during 2 years of dosing and assessment. Periodic plasma drug level determinations provided limited evidence that both compounds may induce their own metabolism. The present results contrast sharply with previously reported effects of long-lasting impairments in the acquisition of incremental learning and in the development of color and position discrimination in these same subjects. These observations highlight the importance of collecting a broad range of toxicology data, including tests of cognitive function, to make comprehensive assessments of new drug safety. In the present case, the less obvious effects of these drugs on cognition defined the toxicologic response. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYL aspartate
KW - SODIUM channels
KW - CLINICAL chemistry
KW - HEMATOLOGY
KW - Clinical chemistry
KW - Fast sodium channels
KW - Hematology
KW - Home-cage behavior
KW - MK-801
KW - N-Methyl-d-aspartate (NMDA)
KW - Ophthalmology
KW - Remacemide
KW - Rhesus monkeys
N1 - Accession Number: 7779700; Popke, E.J. 1 Patton, R. 2 Newport, G.D. 1 Rushing, L.G. 3 Fogle, C.M. 1 Allen, R.R. 4 Pearson, E.C. 5 Hammond, T.G. 5 Paule, M.G. 1; Email Address: mpaule@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Road, Jefferson, AR 72079-950, USA 2: Charles River Laboratories, P.O. Box 26, 3900 NCTR Road, Jefferson AR, USA 3: Division of Chemistry, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR, USA 4: Peak Statistical Services, 5691 Northwood Drive, Evergreen, CO, USA 5: Safety Assessment, AstraZeneca, Bakewell Road, Loughborough-Leics LE11 5RH, Loughborough, England, UK; Source Info: Mar2002, Vol. 24 Issue 2, p193; Subject Term: METHYL aspartate; Subject Term: SODIUM channels; Subject Term: CLINICAL chemistry; Subject Term: HEMATOLOGY; Author-Supplied Keyword: Clinical chemistry; Author-Supplied Keyword: Fast sodium channels; Author-Supplied Keyword: Hematology; Author-Supplied Keyword: Home-cage behavior; Author-Supplied Keyword: MK-801; Author-Supplied Keyword: N-Methyl-d-aspartate (NMDA); Author-Supplied Keyword: Ophthalmology; Author-Supplied Keyword: Remacemide; Author-Supplied Keyword: Rhesus monkeys; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Temple, John G.
AU - Miller, Diane B.
AU - Barthalmus, George T.
T1 - Differential vulnerability of snake species to MPTP:: A behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia)
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2002/03//
VL - 24
IS - 2
M3 - Article
SP - 227
SN - 08920362
AB - The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behavioral and biochemical effects of MPTP were assessed in the black ratsnake Elaphe o. obsoleta and the banded watersnake Nerodia f. fasciata—species that display contrasting behavioral sensitivities to dopaminergic antagonists and to amphibian toxins. We report that MPTP induces depletion of norepinephrine and serotonin in fore, mid and hindbrain regions and depletion of dopamine in fore and midbrain regions in E.o. obsoleta. MPTP also induced a marked reduction in righting ability in E.o. obsoleta. In N.f. fasciata, norepinephrine and dopamine were depleted by MPTP in all three brain regions and serotonin was only significantly reduced in the forebrain. In contrast to E.o. obsoleta, N.f. fasciata demonstrated no behavioral disorders. This study demonstrates a behavioral and biochemical sensitivity to MPTP in E.o. obsoleta that differs from that in N.f. fasciata. The differential sensitivities to monoaminergic modulation may be related to the contrasting diets of these species. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLPHENYLTETRAHYDROPYRIDINE
KW - DOPAMINE
KW - SEROTONIN
KW - REPTILES
KW - Dopamine
KW - Motor control
KW - MPTP
KW - Reptile
KW - Serotonin
N1 - Accession Number: 7779703; Temple, John G. 1; Email Address: jtemple@mwc.edu Miller, Diane B. 2 Barthalmus, George T. 3; Affiliation: 1: Department of Biological Sciences, Mary Washington College, Fredericksburg, VA 22401, USA 2: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 3: Department of Zoology, North Carolina State University, Raleigh, NC 27695-7617, USA; Source Info: Mar2002, Vol. 24 Issue 2, p227; Subject Term: METHYLPHENYLTETRAHYDROPYRIDINE; Subject Term: DOPAMINE; Subject Term: SEROTONIN; Subject Term: REPTILES; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Motor control; Author-Supplied Keyword: MPTP; Author-Supplied Keyword: Reptile; Author-Supplied Keyword: Serotonin; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morehouse, Kim M.
T1 - Food irradiation—US regulatory considerations
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2002/03//
VL - 63
IS - 3-6
M3 - Article
SP - 281
SN - 0969806X
AB - The use of ionizing radiation in food processing has received increased interest as a means of reducing the level of foodborne pathogens. This overview discusses the regulatory issues connected with the use of this technology in the United States. Several recent changes in the FDA''s review process are discussed. These include the current policy that utilizes an expedited review process for petitions seeking approval of additives and technologies intended to reduce pathogen levels in food, and the recent USDA rule that eliminates the need for a separate rulemaking process by USDA for irradiation of meat and poultry. Recently promulgated rules and pending petitions before the FDA associated with the use of ionizing radiation for the treatment of foods are also discussed along with the current FDA labeling requirements for irradiated foods and the 1999 advanced notice of proposed rule on labeling. Another issue that is presented is the current status of the approval of packaging materials intended for food contact during irradiation treatment of foods. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD industry
KW - FOOD irradiation
KW - FDA
KW - Food irradiation
KW - Regulations
N1 - Accession Number: 7764189; Morehouse, Kim M. 1; Email Address: kim.morehouse@cfsan.fda.gov; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 200 C Street, SW, Washington, DC 20204, USA; Source Info: Mar2002, Vol. 63 Issue 3-6, p281; Subject Term: FOOD industry; Subject Term: FOOD irradiation; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Food irradiation; Author-Supplied Keyword: Regulations; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Byun, Myung-Woo
AU - Lee, Ju-Woon
AU - Yook, Hong-Sun
AU - Lee, Kyong-Haeng
AU - Kim, Hee-Yun
T1 - Improvement of shelf stability and processing properties of meat products by gamma irradiation
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2002/03//
VL - 63
IS - 3-6
M3 - Article
SP - 361
SN - 0969806X
AB - To evaluate the effects of gamma irradiation on the processing properties of meat products, emulsion-type sausage, beef patties and pork loin ham were manufactured. Most contaminated bacteria were killed by 3 kGy-irradiation to raw ground beef, and sausage can be manufactured with desirable flavor, a reduction of NaCl and phosphate, and extension of shelf life using gamma irradiation on the raw meat. The beef patties were manufactured with the addition of antioxidants (200 ppm), BHA, ascorbyl palmitate, α -tocopherol, or β -carotene, and gamma-irradiation. Retardation of lipid oxidation appeared at the patties with an antioxidant. A dose of 5 kGy was observed to be as effective as the use of 200 ppm NaNO2 to provide and maintain the desired color of the product during storage. After curing, irradiation, heating and smoking could extensively prolong the shelf life of the hams. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEAT
KW - ANTIOXIDANTS
KW - Antioxidants
KW - Low salts
KW - Meat products
KW - Processing properties
KW - Sodium nitrite
N1 - Accession Number: 7764207; Byun, Myung-Woo 1; Email Address: mwbyun@kaeri.re.kr Lee, Ju-Woon 1 Yook, Hong-Sun 1 Lee, Kyong-Haeng 1 Kim, Hee-Yun 2; Affiliation: 1: Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, Yuseong, Daejeon 305-600, South Korea 2: Division of Food Standard, Korea Food and Drug Administration, 5, Nokbun-Dong, Eunpyung, Seoul 122-744, South Korea; Source Info: Mar2002, Vol. 63 Issue 3-6, p361; Subject Term: MEAT; Subject Term: ANTIOXIDANTS; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: Low salts; Author-Supplied Keyword: Meat products; Author-Supplied Keyword: Processing properties; Author-Supplied Keyword: Sodium nitrite; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Byun, Myung-Woo
AU - Lee, Ju-Woon
AU - Yook, Hong-Sun
AU - Jo, Cheorun
AU - Kim, Hee-Yun
T1 - Application of gamma irradiation for inhibition of food allergy
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2002/03//
VL - 63
IS - 3-6
M3 - Article
SP - 369
SN - 0969806X
AB - This study was carried out to evaluate the application of food irradiation technology as a method for reducing food allergy. Milk β -lactoglobulin, chicken egg albumin, and shrimp tropomyosin were used as model food allergens for experiments on allergenic and molecular properties by gamma irradiation. The amount of intact allergens in an irradiated solution was reduced by gamma irradiation depending upon the dose. These results showed that epitopes on the allergens were structurally altered by radiation treatment and that the irradiation technology can be applied to reduce allergenicity of allergic foods. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD allergy
KW - FOOD irradiation
KW - Food allergy
KW - Gamma irradiation
KW - Reduction of allergenicity
N1 - Accession Number: 7764209; Byun, Myung-Woo 1; Email Address: mwbyun@kaeri.re.kr Lee, Ju-Woon 1 Yook, Hong-Sun 1 Jo, Cheorun 1 Kim, Hee-Yun 2; Affiliation: 1: Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, Yuseong, Daejeon 305-600, South Korea 2: Division of Food Standard, Korea Food and Drug Administration, 5, Nogbun-Dong, Eunpyung, Seoul 122-704, South Korea; Source Info: Mar2002, Vol. 63 Issue 3-6, p369; Subject Term: FOOD allergy; Subject Term: FOOD irradiation; Author-Supplied Keyword: Food allergy; Author-Supplied Keyword: Gamma irradiation; Author-Supplied Keyword: Reduction of allergenicity; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buchalla, Rainer
AU - Begley, Timothy H.
AU - Morehouse, Kim M.
T1 - Analysis of low-molecular weight radiolysis products in extracts of gamma-irradiated polymers by gas chromatography and high-performance liquid chromatography
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2002/03//
VL - 63
IS - 3-6
M3 - Article
SP - 837
SN - 0969806X
AB - Estimating exposure to radiolysis products of polymers is an important part of the regulatory evaluation of packaging materials for use in food irradiation. However, as Koni Grob recently put it, the comprehensive analysis of migrants is a challenge. This paper discusses some of the analytical difficulties and presents results obtained with extracts of irradiated polystyrene and polyamide-6. The results indicate that headspace or thermal desorption techniques may, in some instances, lead to an overestimation of radiolysis product concentrations. It is concluded that validated analytical methods and a better understanding of the underlying radiation chemistry would greatly facilitate the safety assessment of irradiated packaging materials. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PACKAGING
KW - RADIATION chemistry
KW - Ionizing radiation
KW - Packaging materials
KW - Radiolysis products
N1 - Accession Number: 7764313; Buchalla, Rainer; Email Address: rainer.buchalla@cfsan.fda.gov Begley, Timothy H. 1 Morehouse, Kim M. 1; Affiliation: 1: US Food and Drug Administration, Division of Product Manufacture and Use, HFS-245, 200 C Street SW, Washington DC 20204, USA; Source Info: Mar2002, Vol. 63 Issue 3-6, p837; Subject Term: PACKAGING; Subject Term: RADIATION chemistry; Author-Supplied Keyword: Ionizing radiation; Author-Supplied Keyword: Packaging materials; Author-Supplied Keyword: Radiolysis products; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bebak-Williams, Julie
AU - Bullock, Graham
AU - Carson, Mary C.
T1 - Oxytetracycline residues in a freshwater recirculating system
JO - Aquaculture
JF - Aquaculture
Y1 - 2002/03/11/
VL - 205
IS - 3/4
M3 - Article
SP - 221
SN - 00448486
AB - When oxytetracycline (OTC) medicated feed is fed to fish in a recirculating aquaculture system, antibiotic residues could accumulate in fish tissue, water, biofilter sand and sediment to a greater extent than in single pass or serial reuse aquaculture systems. In two trials, oxytetracycline-medicated feed (3 g active ingredient per pound of feed) was fed to adult rainbow trout at 1% b.w. per day for 10 days. OTC residues were assayed in fish muscle (with skin attached), water, sediment (e.g., fish feces, uneaten feed) and biofilter sand. For both trials, oxytetracycline was detected during the 10 days of treatment in all matrices assayed. In trout muscle, OTC concentrations increased to an average of 1.8 μg/g by day 10 of treatment and then declined to <0.2 μg/g by 21 days post-treatment. For water entering and exiting the biofilter, OTC concentrations increased to 0.5 μg/ml by day 10 and was not detectable (<0.001 μg/ml) by 21 days post-treatment. For biofilter sand, OTC concentration was approximately 14 μg/g by day 10 and decreased to <2 μg/g by 21 days post-treatment. In sediment samples, OTC concentrations increased to 1900 μg/g by day 10 and declined to <2 μg/g by 21 days post-treatment. In this system, OTC concentrations in trout muscle were well below 2 μg/g by 21 days after withdrawal of the drug. After input of medicated feed to the system was stopped, OTC concentrations in water, sediment and the biofilter declined and did not increase during the post-treatment period. [Copyright &y& Elsevier]
AB - Copyright of Aquaculture is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXYTETRACYCLINE
KW - RAINBOW trout
KW - Antibiotics
KW - Oxytetracycline
KW - Rainbow trout
KW - Recirculating system
KW - Residues
N1 - Accession Number: 7761855; Bebak-Williams, Julie 1; Email Address: j.bebak@freshwaterinstitute.org Bullock, Graham 1 Carson, Mary C. 2; Affiliation: 1: Freshwater Institute, P.O. Box 1889, Shepherdstown, WV 25443, USA 2: Division of Residue Chemistry, U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Mar2002, Vol. 205 Issue 3/4, p221; Subject Term: OXYTETRACYCLINE; Subject Term: RAINBOW trout; Author-Supplied Keyword: Antibiotics; Author-Supplied Keyword: Oxytetracycline; Author-Supplied Keyword: Rainbow trout; Author-Supplied Keyword: Recirculating system; Author-Supplied Keyword: Residues; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Jong Kwan
AU - Lee, Kwang Hee
AU - Lee, Chang Hyung
T1 - Liquid phase behavior and its effect on crystalline morphology in the extruded poly(ethylene terephthalate)/poly(ethylene-2,6-naphthalate) blend
JO - Polymer
JF - Polymer
Y1 - 2002/03/15/
VL - 43
IS - 6
M3 - Article
SP - 1897
SN - 00323861
AB - Morphology in an extruded poly(ethylene terephthalate)/poly(ethylene-2,6-naphthalate) was investigated using time-resolved light scattering, optical microscope and small-angle X-ray scattering. During annealing at 280 °C, the domain structure via spinodal decomposition preceded, the transesterification followed, and then the transesterification between the two polyesters induced the dissolution of the liquid–liquid (L–L) phase separation, i.e. the homogenization. The annealed specimen for various time periods (ts) at 280 °C was subjected to a temperature-drop to 120 °C for the isothermal crystallization and then the effects of liquid phase morphology on crystallization was investigated. With ts, the Hν (cross-polarization) light scattering patterns exhibited the dramatic change from a four-leaf clover pattern with maximum intensity at azimuthal angle 45° (×-type scattering pattern) to a diffuse pattern of circular symmetry and then a four-leaf clover pattern with maximum intensity at azimuthal angles 0 and 90° (+-type scattering pattern). This suggests that the crystalline structure depends on the level of the block and/or random copolymer produced by the transesterification during annealing. The Hν scattering patterns reflected differences in the principle polarizability of the crystalline lamellae with respect to the spherulitic radius. On the other hand, the long period LB, an average distance between two adjacent crystalline lamellae, increased with ts at 280 °C. The dependence of LB on ts was explained by the change in the crystallization rate G. [Copyright &y& Elsevier]
AB - Copyright of Polymer is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYSTALLINE polymers
KW - POLYETHYLENE terephthalate
KW - Blend
KW - Crystalline morphology
KW - Phase behavior
N1 - Accession Number: 7741243; Lee, Jong Kwan 1 Lee, Kwang Hee 1 Lee, Chang Hyung 2; Email Address: c-hlee@kfda.go.kr; Affiliation: 1: Center for Advanced Functional Polymers, School of Chemical Science and Engineering, Inha University, Inchon 402-751, South Korea 2: Department of Medical Devices and Radiation Health, Korea Food and Drug Administration, 5 Nokbeon-dong, Eunpyung-ku, Seoul, South Korea; Source Info: Mar2002, Vol. 43 Issue 6, p1897; Subject Term: CRYSTALLINE polymers; Subject Term: POLYETHYLENE terephthalate; Author-Supplied Keyword: Blend; Author-Supplied Keyword: Crystalline morphology; Author-Supplied Keyword: Phase behavior; NAICS/Industry Codes: 325220 Artificial and Synthetic Fibers and Filaments Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chang, Cheng-Nan
AU - Wu, Yuh-Shen
AU - Lu, Shin-Chung
AU - Pi-Cheng Fu, Peter
AU - Chang, Shyh-Chyi
AU - Cheng, Chii-Dong
AU - Yuen, Win-Hsiao
T1 - Concentration of atmospheric particulates during a dust storm period in central Taiwan, Taichung
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2002/03/15/
VL - 287
IS - 1/2
M3 - Article
SP - 141
SN - 00489697
AB - In this study we monitored concentrations of particles in central Taiwan using PS-1 (GPS1 PUF Sampler) and Model 310 Universal Air Sampler™ (UASTM) from 02/23/2001 to 03/12/2001 at two sampling sites. During this period, an Asian dust storm moved across central Taiwan from 3/3 to 3/6. The total ambient air particle concentrations during the dust storm period were than compared with previous data from this region. In general, the average total suspended particulate (TSP) concentration order was during dust storm period>after dust storm period>non-dust storm period at both HKITT (traffic) and THUC (rural) sampling sites. The ratio of PM2.5/PM10 was 60% before and after the dust storm period. However, this ratio was decreased to less than 50% during the dust storm. This demonstrates that the coarse particulate concentrations (PM2.5–10) increased during the dust storm period. In contrast the increase of ambient air particles concentrations after the Taiwan Chi-Chi Earthquake were mainly due to fine particles (PM2.5). And, the increased of ambient air particles concentrations after dust storm period were mainly coarse particle (PM2.5–10) concentrations in central Taiwan. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR pollution
KW - AIR quality
KW - Dust-storm
KW - Fugitive dust
KW - Particulate matter
KW - PM2.5–10
KW - PM2.5
KW - Total suspended particulate
N1 - Accession Number: 7753557; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw Chang, Cheng-Nan 2 Wu, Yuh-Shen 1 Lu, Shin-Chung 1 Pi-Cheng Fu, Peter 3 Chang, Shyh-Chyi 2 Cheng, Chii-Dong 2 Yuen, Win-Hsiao 4; Affiliation: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang Institute of Technology, Sha-Lu, Taichung 433, Taiwan, ROC 2: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan, ROC 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AK 72079, USA 4: Department of Chemical Engineering, Hsiuping Institute of Technology, Taichung 412, Taiwan, ROC; Source Info: Mar2002, Vol. 287 Issue 1/2, p141; Subject Term: AIR pollution; Subject Term: AIR quality; Author-Supplied Keyword: Dust-storm; Author-Supplied Keyword: Fugitive dust; Author-Supplied Keyword: Particulate matter; Author-Supplied Keyword: PM2.5–10; Author-Supplied Keyword: PM2.5; Author-Supplied Keyword: Total suspended particulate; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khaidakov, Magomed
AU - Manjanatha, Mugimane G.
AU - Aidoo, Anane
T1 - Molecular analysis of mitochondrial DNA mutations from bleomycin-treated rats
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/03/20/
VL - 500
IS - 1/2
M3 - Article
SP - 1
SN - 00275107
AB - In our previous studies, we have shown the mutagenicity of bleomycin (BLM) at the nuclear hprt locus. In the present study we have analyzed mutagenic effects of BLM in mitochondrial DNA (mtDNA) using short extension-PCR (SE-PCR) method for detection of low-copy deletions. Fisher 344 rats were treated with a single dose of BLM and total DNA preparations from splenic lymphocytes were processed in SE-PCR assay. Spontaneous deletions were typically flanked by direct repeats (78.5%), while the in BLM-treated group, direct repeats were found in only 46.6% of breakpoints. The ratio between deletions based on direct repeats and random sequence deletions changed from 3.67 in control group to 0.87 in BLM-treated animals, which corresponds to an approximate 1.7-fold increase in the deletion mutation frequency. Furthermore, 62.5% of deletions not flanked by direct repeats in the treated group contained cleavage sites for BLM. The localization of breakpoints was not entirely random. We have found four clusters containing deletions from both groups indicative of deletion hot spots. The results indicate that BLM exposure may be associated with the induction of mtDNA mutations, and suggest the utility of SE-PCR method for evaluating drug-induced genotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENESIS
KW - BLEOMYCIN
KW - Bleomycin
KW - Deletion
KW - Mitochondrial DNA
KW - Mutation
N1 - Accession Number: 7766470; Khaidakov, Magomed 1; Email Address: mkhaidakov@nctr.fda.gov Manjanatha, Mugimane G. 1 Aidoo, Anane 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson Laboratories of the FDA, Jefferson, AR 72079, USA; Source Info: Mar2002, Vol. 500 Issue 1/2, p1; Subject Term: MUTAGENESIS; Subject Term: BLEOMYCIN; Author-Supplied Keyword: Bleomycin; Author-Supplied Keyword: Deletion; Author-Supplied Keyword: Mitochondrial DNA; Author-Supplied Keyword: Mutation; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stefanski, Roman
AU - Lee, Sun-Hee
AU - Yasar, Sevil
AU - Cadet, Jean L.
AU - Goldberg, Steven R.
T1 - Lack of persistent changes in the dopaminergic system of rats withdrawn from methamphetamine self-administration
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2002/03/29/
VL - 439
IS - 1-3
M3 - Article
SP - 59
SN - 00142999
AB - A continuing challenge for studies in the neurobiology of drug abuse is to identify and characterize long-lived neuroadaptations that can trigger craving and relapse. We previously reported that rats that had actively self-administered methamphetamine for 5 weeks and were then withdrawn from methamphetamine for 24 h showed marked decreases in somatodendritic dopamine D2 autoreceptor levels in the ventral tegmental area and median and dorsal part of the substantia nigra zona compacta with a corresponding down-regulation of dopamine D1 receptors in the shell of the nucleus accumbens. The purpose of the present study was to determine whether neuroadaptive changes in dopamine receptors or transporters in the brains of rats withdrawn for 24 h from chronic methamphetamine self-administration are persistent changes that can be demonstrated long after withdrawal. A “yoked” procedure was used in which rats were tested simultaneously in groups of three, with only one rat actively self-administering methamphetamine while the other two received yoked injections of either methamphetamine or saline. In vitro quantitative autoradiography was used to determine densities of dopamine uptake sites and dopamine D1 and D2 receptors in different brain regions following 7- and 30-day periods of withdrawal from chronic methamphetamine self-administration. No changes in dopamine transporter and dopamine receptor numbers were detected in any brain region examined in rats self-administering methamphetamine compared with littermates receiving yoked infusions of either methamphetamine or saline. Thus, neuroadaptive changes in densities of dopamine receptors or transporters in certain brain areas may contribute to the reinforcing effects of methamphetamine during the acquisition and maintenance phases of self-administration, but do not appear to contribute to the long-lasting neuroadaptive effects of chronic methamphetamine self-administration, which may trigger craving and relapse. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - NEUROBIOLOGY
KW - (Rat)
KW - Dopamine
KW - Drug self-administration
KW - Methamphetamine
KW - Neuroadaptation
N1 - Accession Number: 7776420; Stefanski, Roman 1,2 Lee, Sun-Hee 1,3 Yasar, Sevil 1,4 Cadet, Jean L. 5 Goldberg, Steven R. 1; Email Address: sgoldber@intra.nida.nih.gov; Affiliation: 1: Preclinical Pharmacology Section, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA 2: Department of Pharmacology, Institute of Psychiatry and Neurology, Al. Sobieskiego 1/9, 02-957 Warsaw, Poland 3: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5, Nokbun-dong, Eunpyung-gu, Seoul, 122-704, South Korea 4: Johns Hopkins School of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins Bayview Medical Center, 5505 Johns Hopkins Circle, Baltimore, MD 21224, USA 5: Molecular Neuropsychiatry Section, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA; Source Info: Mar2002, Vol. 439 Issue 1-3, p59; Subject Term: DRUG abuse; Subject Term: NEUROBIOLOGY; Author-Supplied Keyword: (Rat); Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Drug self-administration; Author-Supplied Keyword: Methamphetamine; Author-Supplied Keyword: Neuroadaptation; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Silvers, Linda E.
AU - Varricchio, Frederick E.
AU - Ellenberg, Susan S.
AU - Krueger, Carol L.
AU - Wise, Robert P.
AU - Salive, Marcel E.
T1 - Pediatric deaths reported after vaccination: the utility of information obtained from parents
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2002/04//
VL - 22
IS - 3
M3 - Article
SP - 170
SN - 07493797
AB - Background: The federally administered Vaccine Adverse Event Reporting System (VAERS) is a passive reporting system that receives domestic and foreign reports of adverse events that occur following immunization. This investigation explored whether routinely interviewing parents for follow-up of VAERS pediatric deaths would provide additional information important to vaccine safety.Methods: The study was designed to follow up 100 consecutive pediatric deaths reported to VAERS by interviewing a parent and a healthcare provider (HCP) for each case. Several strategies contributed to successful follow-up. A standardized questionnaire was utilized to interview HCPs and parents. Overall and specific group frequencies (HCPs and parents) were calculated for each variable. McNemar’s statistical tests of exact inference were calculated to assess whether there were statistically significant differences between HCP and parent knowledge by case for various variables.Results: The median age of the cases was 4 months. Approximately half of the deaths were attributed to sudden infant death syndrome. In many instances, the information was equivalent in quality. For certain variables, such as knowledge of the child’s position when found in distress, more parents than HCPs indicated that they knew the answer.Conclusions: Conducting parental and HCP follow-up for pediatric deaths reported to VAERS was resource intensive. In some instances, parents were more likely than HCPs to provide information regarding some important variables about the nature of the death. None of the additional information obtained from parents, however, provided a signal or confirmation of a causal link between the vaccine and death. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - IMMUNIZATION
KW - SAFETY measures
KW - child
KW - follow-up studies
KW - health personnel
KW - parents
KW - safety
KW - sudden infant death
KW - vaccines
N1 - Accession Number: 7767070; Silvers, Linda E. 1; Email Address: Lsilvers@cvm.fda.gov Varricchio, Frederick E. 1 Ellenberg, Susan S. 1 Krueger, Carol L. 1 Wise, Robert P. 1 Salive, Marcel E. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Rockville, Maryland, USA; Source Info: Apr2002, Vol. 22 Issue 3, p170; Subject Term: VACCINES; Subject Term: IMMUNIZATION; Subject Term: SAFETY measures; Author-Supplied Keyword: child; Author-Supplied Keyword: follow-up studies; Author-Supplied Keyword: health personnel; Author-Supplied Keyword: parents; Author-Supplied Keyword: safety; Author-Supplied Keyword: sudden infant death; Author-Supplied Keyword: vaccines; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zlotnick, Cheryl
AU - Marks, Lori
T1 - Case Management Services at Ten Federally Funded Sites Targeting Homeless Children and Their Families.
JO - Children's Services: Social Policy, Research & Practice
JF - Children's Services: Social Policy, Research & Practice
Y1 - 2002/04//
VL - 5
IS - 2
M3 - Article
SP - 113
EP - 122
PB - Taylor & Francis Ltd
SN - 10939644
AB - Of the 128 federally funded projects providing health care to homeless people, only 10 specifically target homeless children. In this article we describe these 10 health care for the homeless projects, the case managers, and the children that they serve. Data collected from the case managers and from federal reports demonstrated differences among projects by case manager characteristics, number of children served, and federal funding levels. Case management is a legislatively mandated service for the federally funded homeless children's grantees, but its implementation is very diverse. These different sites illustrate the different ways that a federally funded program has evolved to meet the needs of its community. [ABSTRACT FROM AUTHOR]
AB - Copyright of Children's Services: Social Policy, Research & Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL services case management
KW - HOMELESS persons
KW - HOMELESS children
KW - GOVERNMENT aid
KW - MEDICAL care
N1 - Accession Number: 6575840; Zlotnick, Cheryl 1; Email Address: czlotnick@aol.com Marks, Lori 2; Affiliation: 1: Center for the Vulnerable Child at Children's Hospital Oakland Oakland, CA 2: Health Care for the Homeless Program Division of Programs for Special Populations Bureau of Primary Health Care, Health Resources and Services Administration; Source Info: 2002, Vol. 5 Issue 2, p113; Subject Term: SOCIAL services case management; Subject Term: HOMELESS persons; Subject Term: HOMELESS children; Subject Term: GOVERNMENT aid; Subject Term: MEDICAL care; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sutherland, M. F.
AU - Drew, A.
AU - Rolland, J. M.
AU - Slater, J. E.
AU - Suphioglu, C.
AU - O'Hehir, R. E.
T1 - Specific monoclonal antibodies and human immunoglobulin E show that Hev b 5 is an abundant allergen in high protein powdered latex gloves.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2002/04//
VL - 32
IS - 4
M3 - Article
SP - 583
EP - 589
PB - Wiley-Blackwell
SN - 09547894
AB - Summary Background Hev b 5 is a major latex allergen recognized predominantly by latex-allergic health care workers (HCWs). Recombinant Hev b 5 (rHev b 5) was previously expressed as a fusion protein with maltose binding protein (MBP), itself an immunogenic molecule; therefore non-fusion rHev b 5 is desirable. Moreover, standardized immunological assays for the detection of Hev b 5 are currently lacking and may have important implications for both allergen avoidance and diagnosis in latex allergy. Objectives To generate and use Hev b 5-specific mAbs to determine the relative abundance of Hev b 5 in different latex extracts, correlating this with the IgE reactivity of latex-allergic HCWs and to produce non-fusion rHev b 5. Methods For the production of mAbs, mice were immunized with rHev b 5/MBP fusion protein and mAbs selected with rHev b 5/MBP but not MBP reactivity. The mAb reactivity was compared with polyclonal IgE from latex-allergic HCWs using direct and inhibition ELISA and immunoblot assays. Recombinant Hev b 5 was expressed and purified in the pPROEX-HTa bacterial expression system. Results Four Hev b 5-specific mAbs were produced. Immunoblotting and ELISA using the mAbs indicate abundant Hev b 5 in high protein powdered latex glove extracts as compared with crude latex sap extracts. High quality surgical gloves with no detectable protein have no detectable Hev b 5. Inhibition ELISAs using serum IgE from latex-allergic HCWs and Hev b 5-specific mAbs gave strong correlation. Non-fusion recombinant Hev b 5 was successfully expressed and purified, showing reactivity with both the Hev b 5-specific mAbs and serum IgE of latex-allergic HCWs. Conclusion Hev b 5-specific mAbs and human IgE from latex-allergic HCWs demonstrate the greater content of Hev b 5 in high protein powdered glove extracts. This may explain the observed higher frequency of sensitization to this allergen in HCWs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - MONOCLONAL antibodies
KW - ALLERGY
KW - Hev b 5
KW - latex allergy
KW - latex gloves
KW - monoclonal antibodies
KW - recombinant proteins
N1 - Accession Number: 6542280; Sutherland, M. F. 1,2 Drew, A. 1,2 Rolland, J. M. 2,3 Slater, J. E. 4 Suphioglu, C. 1,2 O'Hehir, R. E. 1,2; Affiliation: 1: Allergy, Asthma and Clinical Immunology, and 2: Co-operative Research Centre for Asthma, Sydney, Australia; and the 3: Pathology and Immunology, The Alfred Hospital and Monash University, Victoria, 4: Laboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA; Source Info: Apr2002, Vol. 32 Issue 4, p583; Subject Term: LATEX; Subject Term: MONOCLONAL antibodies; Subject Term: ALLERGY; Author-Supplied Keyword: Hev b 5; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: latex gloves; Author-Supplied Keyword: monoclonal antibodies; Author-Supplied Keyword: recombinant proteins; Number of Pages: 0p; Illustrations: 5 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.0954-7894.2002.01355.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - PETTIFORD, J. N
AU - JASON, J
AU - NWANYANWU, O. C
AU - ARCHIBALD, L. K
AU - KAZEMBE, P. N
AU - DOBBIE, H
AU - JARVIS, W. R
T1 - Age-related differences in cell-specific cytokine production by acutely ill Malawian patients*.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2002/04//
VL - 128
IS - 1
M3 - Article
SP - 110
EP - 117
PB - Wiley-Blackwell
SN - 00099104
AB - SUMMARY Age-related changes in human cell-specific cytokine responses to acute illness have not been well examined. We therefore evaluated age-related differences in T, B and natural killer (NK) peripheral blood lymphocyte cytokine responses of 309 acutely ill hospitalized people in Malawi, Africa, <1 month–61 years of age. We used four-colour flow cytometry and performed Wilcoxon rank sum and Kruskal–Wallis tests, Pearson (r p ) and Spearman (r s ) correlations, and linear and logistic regression analyses to control for human immunodeficiency virus infection (HIV) status, the percentages of lymphocytes expressing CD4, and the nature of the acute infection. The percentages of CD8- and CD8+ T cells producing induced IL-8 decreased with age (r s = -0·44 and -0·53). The percentages of T cells producing TNF-α were higher, and the percentages producing IL-10 were lower, in those ≥13 than those <13 years old (medians: 17·7 versus 10·5 and 1·4 versus 3·0, respectively). The percentages of CD8- T cells producing IFN-γ were higher and stable in those ≥1 year old compared to infants (medians: 23·5 versus 10·4); the percentages of NK producing IFN-γ were higher post-infancy and then declined to relatively low levels with increasing age. The percentages of T cells producing IL-2 were highest in those 5–<31 years old (median 5·6) and lowest in those ≥31 years old (median 1·9). The ratios of the percentages of T cells producing IL-4 to those producing IL-8 and to those producing IL-10 both increased with age. These data suggest that innate immunity, represented by NK IFN-γ production, dominates in early life. A number of shifts occur after infancy and before adolescence, including a proinflammatory shift from IL-8 to TNF-γ and a type 2 shift from IL-10 to IL-4 dominance. These findings suggest... [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - DISEASES
KW - LYMPHOCYTES -- Aging
KW - IMMUNOLOGY
KW - age
KW - cytokine balance
KW - IFN-γ IL-8 immunosenescence T lymphocytes
N1 - Accession Number: 6573761; PETTIFORD, J. N 1 JASON, J 1 NWANYANWU, O. C 2 ARCHIBALD, L. K 3 KAZEMBE, P. N 4 DOBBIE, H 4 JARVIS, W. R 3; Affiliation: 1: HIV Immunology and Diagnostics Branch, Division of AIDS, STD and TB Laboratory Research (DASTLR), 2: Office of Global Health, 3: Investigation & Prevention Branch, Hospital Infections Program, National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services (DHHS), US Public Health Service (PHS), Atlanta, GA, USA and 4: Lilongwe Central Hospital and Community Health Sciences Unit, Ministry of Health and Population, Lilongwe, Malawi; Source Info: Apr2002, Vol. 128 Issue 1, p110; Subject Term: CYTOKINES; Subject Term: DISEASES; Subject Term: LYMPHOCYTES -- Aging; Subject Term: IMMUNOLOGY; Author-Supplied Keyword: age; Author-Supplied Keyword: cytokine balance; Author-Supplied Keyword: IFN-γ IL-8 immunosenescence T lymphocytes; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1365-2249.2002.01813.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Szarfman, A.
AU - Machado, S.G.
AU - O'Neill, R.T.
T1 - Use of Screening Algorithms and Computer Systems to Efficiently Signal Higher-Than-Expected Combinations of Drugs and Events in the US FDA's Spontaneous Reports Database.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/04//
VL - 25
IS - 6
M3 - Article
SP - 381
EP - 392
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Since 1998, the US Food and Drug Administration (FDA) has been exploring new automated and rapid Bayesian data mining techniques. These techniques have been used to systematically screen the FDA's huge MedWatch database of voluntary reports of adverse drug events for possible events of concern. The data mining method currently being used is the Multi-Item Gamma Poisson Shrinker (MGPS) program that replaced the Gamma Poisson Shrinker (GPS) program we originally used with the legacy database. The MGPS algorithm, the technical aspects of which are summarised in this paper, computes signal scores for pairs, and for higher-order (e.g. triplet, quadruplet) combinations of drugs and events that are significantly more frequent than their pair-wise associations would predict. MGPS generates consistent, redundant, and replicable signals while minimising random patterns. Signals are generated without using external exposure data, adverse event background information, or medical information on adverse drug reactions. The MGPS interface streamlines multiple input-output processes that previously had been manually integrated. The system, however, cannot distinguish between already-known associations and new associations, so the reviewers must filter these events. In addition to detecting possible serious single-drug adverse event problems, MGPS is currently being evaluated to detect possible synergistic interactions between drugs (drug interactions) and adverse events (syndromes), and to detect differences among subgroups defined by gender and by age, such as paediatrics and geriatrics. In the current data, only 3.4% of all 1.2 million drug-event pairs ever reported (with frequencies ≥1) generate signals [lower 95% confidence interval limit of the adjusted ratios of the observed counts over expected (O/E) counts (denoted EB05) of ≥2]. The total frequency count that contributed to signals comprised 23% (2.4 million) of the total number, 10.4 million of drug-event pairs reported, greatly facilitating a more focused follow-up and evaluation. The algorithm provides an objective, systematic view of the data alerting reviewers to critically important, new safety signals. The study of signals detected by current methods, signals stored in the Center for Drug Evaluation and Research's Monitoring Adverse Reports Tracking System, and the signals regarding cerivastatin, a cholesterol-lowering drug voluntarily withdrawn from the market in August 2001, exemplify the potential of data mining to improve early signal detection. The operating characteristics of data mining in detecting early safety signals, exemplified by studying a drug recently well characterised by large clinical trials confirms our experience that the signals generated by data mining have high enough specificity to deserve further investigation. The application of these tools may ultimately improve usage recommendations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATA mining
KW - BAYESIAN analysis
KW - DRUGS
KW - UNITED States
KW - Adverse reaction monitoring
KW - Electronic information services
N1 - Accession Number: 6911734; Szarfman, A. 1 Machado, S.G. 1 O'Neill, R.T. 1; Affiliation: 1: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Apr2002, Vol. 25 Issue 6, p381; Subject Term: DATA mining; Subject Term: BAYESIAN analysis; Subject Term: DRUGS; Subject Term: UNITED States; Author-Supplied Keyword: Adverse reaction monitoring; Author-Supplied Keyword: Electronic information services; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garthoff, L.H.
AU - Henderson, G.R.
AU - Sager, A.O.
AU - Sobotka, T.J.
AU - O'Dell, R.
AU - Thorpe, C.W.
AU - Trotter, W.J.
AU - Bruce, V.R.
AU - Dallas, H.L.
AU - Poelma, P.L.
AU - Solomon, H.M.
AU - Bier, J.W.
AU - O'Donnell Jr, M.W.
AU - Chi, R.K.
AU - Chirtel, S.J.
AU - Barton, C.N.
AU - Brown, L.H.
AU - Frattali, V.P.
AU - Khan, M.A.
T1 - The Autosow raised miniature swine as a model for assessing the effects of dietary soy trypsin inhibitor
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2002/04//
VL - 40
IS - 4
M3 - Article
SP - 487
SN - 02786915
AB - Toxicological effects of dietary soy trypsin inhibitor (TI) were assessed in male miniature swine, a model chosen for its similarities to human digestive physiology and anatomy. The TI preparation was extracted from defatted raw soy flour. From 1 through 5 weeks of age, piglets were automatically fed either a TI liquid diet [Autosow TI group (ASTI)] or a control liquid diet [Autosow control group (ASC)]. From 6 to 39 weeks of age, these animals received either swine chow and TI or swine chow and control article. The TI diets were formulated to contain a TI activity of approximately 500 mg TI/100 g dry matter. A sow control (SC) group suckled from birth to 6 weeks of age and then fed as the ASC group with swine chow plus control article from 6 to 39 weeks of age. The SC piglets grew faster than ASC piglets during postnatal weeks 1 and 2; however, the ASC piglets were significantly heavier than the SC piglets (P=0.001) at 6 weeks of age. Compared with the ASC group, TI caused a moderate decrease in feed consumption and a moderate but reversible decrease in growth from 2 to 5 weeks of age, but not thereafter. Some control and TI-fed Autosow-reared piglets had loose stools until 6 weeks of age; the effect was significantly greater in the TI-fed group. Otherwise, all swine were active and had normal appearance and behavior. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRYPSIN
KW - TOXICOLOGY
KW - DIET
KW - NUTRITION
KW - analysis of variance (ANOVA)
KW - Autosow control (ASC)
KW - Autosow trypsin inhibitor (ASTI)
KW - cholecystokinin (CCK)
KW - deoxyribonucleic acid (DNA)
KW - Food and Drug Administration (FDA)
KW - gastrointestinal (GI)
KW - International Business Machines (IBM)
KW - least squares mean (LSM)
KW - N-benzoyl-dl-arginine-p-nitroanilide (BAPNA)
KW - polychlorinated biphenyl (PCB)
KW - ribonucleic acid (RNA)
KW - sow control (SC)
KW - trypsin inhibitor (TI)
KW - United States Department of Agriculture. (USDA)
N1 - Accession Number: 7764037; Garthoff, L.H. 1; Email Address: lgarthof@cfsan.fda.gov Henderson, G.R. 1 Sager, A.O. 1 Sobotka, T.J. 1 O'Dell, R. 2 Thorpe, C.W. 3 Trotter, W.J. 3 Bruce, V.R. 4 Dallas, H.L. 4 Poelma, P.L. 4 Solomon, H.M. 4 Bier, J.W. 4 O'Donnell Jr, M.W. 5 Chi, R.K. 5 Chirtel, S.J. 5 Barton, C.N. 5 Brown, L.H. 5 Frattali, V.P. 6 Khan, M.A. 1; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicological Research and Nutritional Product Studies, Muirkirk Research Center, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Office of Special Nutritionals, Division of Programs and Enforcement Policy, Methods Research Branch, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 3: Division of Pesticides and Industrial Chemicals, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 4: Division of Microbiological Studies, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 5: Division of Mathematics, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 6: Office of the Center Director, 5100 Paint Branch Parkway, College Park, MD, 20740, USA; Source Info: Apr2002, Vol. 40 Issue 4, p487; Subject Term: TRYPSIN; Subject Term: TOXICOLOGY; Subject Term: DIET; Subject Term: NUTRITION; Author-Supplied Keyword: analysis of variance (ANOVA); Author-Supplied Keyword: Autosow control (ASC); Author-Supplied Keyword: Autosow trypsin inhibitor (ASTI); Author-Supplied Keyword: cholecystokinin (CCK); Author-Supplied Keyword: deoxyribonucleic acid (DNA); Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: gastrointestinal (GI); Author-Supplied Keyword: International Business Machines (IBM); Author-Supplied Keyword: least squares mean (LSM); Author-Supplied Keyword: N-benzoyl-dl-arginine-p-nitroanilide (BAPNA); Author-Supplied Keyword: polychlorinated biphenyl (PCB); Author-Supplied Keyword: ribonucleic acid (RNA); Author-Supplied Keyword: sow control (SC); Author-Supplied Keyword: trypsin inhibitor (TI); Author-Supplied Keyword: United States Department of Agriculture. (USDA); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garthoff, L.H.
AU - Henderson, G.R.
AU - Sager, A.O.
AU - Sobotka, T.J.
AU - Gaines, D.W.
AU - O'Donnell Jr, M.W.
AU - Chi, R.
AU - Chirtel, S.J.
AU - Barton, C.N.
AU - Brown, L.H.
AU - Hines, F.A.
AU - Solomon, T.
AU - Turkleson, J.
AU - Berry, D.
AU - Dick, H.
AU - Wilson, F.
AU - Khan, M.A.
T1 - Pathological evaluation, clinical chemistry and plasma cholecystokinin in neonatal and young miniature swine fed soy trypsin inhibitor from 1 to 39 weeks of age
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2002/04//
VL - 40
IS - 4
M3 - Article
SP - 501
SN - 02786915
AB - The potential toxicity of dietary soy trypsin inhibitor (TI) was evaluated in neonatal miniature swine. From 1 to 6 weeks of age, two groups of male piglets were artificially reared in an Autosow and automatically fed either TI or control liquid diet. From 6 to 39 weeks of age, these two groups were fed either TI or control chow diet. A third group, sow control (SC), suckled from birth to 6 weeks of age, were also weaned to control chow from 6 to 39 weeks of age. Clinical chemistry and plasma cholecystokinin (CCK) determined at 6, 18, 30 and 39 weeks of age, and serum amylase activity with gross and histopathological analyses of major organs at 6 and 39 weeks of age are reported. TI had no effect on plasma CCK, serum amylase activity, or numerous clinical chemistry values. TI-fed piglets had a larger relative liver weight at 6 weeks of age. Relative pancreas weight decreased with age but was not affected by TI. Gross and histopathological analyses of major organs, except the spleen, were within normal limits. Increased incidence of extramedullary hematopoiesis was noted in the spleen of the TI group at 6 but not at 39 weeks of age. There was no consistent pattern in immunohistochemical foci for secretin, gastrin releasing polypeptide or CCK, and no change in DNA, RNA, mitotic index or nuclear density of pancreatic cells. At 6 weeks of age, TI increased pancreatic protein and amylase activity but not trypsin or chymotrypsin activity. None of the effects suggested that this dose of TI was toxic to either the neonatal or sexually mature miniature male swine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOLOGY
KW - CLINICAL chemistry
KW - PLASMA chemistry
KW - CHOLECYSTOKININ
KW - analysis of variance (ANOVA)
KW - Autosow control group (ASC)
KW - Autosow trypsin inhibitor group (ASTI)
KW - blood urea nitrogen (BUN)
KW - Center for Food Safety and Applied Nutrition (CFSAN)
KW - cholecystokinin (CCK)
KW - deoxyribonucleic acid (DNA)
KW - ethylenediaminetetraacetic acid (EDTA)
KW - extramedullary hematopoiesis (EMH)
KW - Food and Drug Administration (FDA)
KW - gamma-glutamyl transpeptidase (GGTP)
KW - gastrin releasing peptide (GRP)
KW - lactate dehydrogenase (LDH)
KW - least squares mean (LSM)
KW - liquid test diet (LTD)
KW - mean corpuscular hemoglobin (MCH)
KW - mean corpuscular hemoglobin concentration (MCHC)
KW - mean corpuscular volume (MCV)
KW - ornithine decarboxylase (ODC)
KW - red cell distribution width (RCDW)
KW - ribonucleic acid (RNA)
KW - serum glutamic–oxaloacetic transaminase (SGOT)
KW - serum glutamic–pyruvic transaminase (SGPT)
KW - sow control (SC)
KW - trypsin inhibitor. (TI)
N1 - Accession Number: 7764038; Garthoff, L.H. 1; Email Address: lgarthof@cfsan.fda.gov Henderson, G.R. 1 Sager, A.O. 1 Sobotka, T.J. 1 Gaines, D.W. 1 O'Donnell Jr, M.W. 2 Chi, R. 2 Chirtel, S.J. 2 Barton, C.N. 2 Brown, L.H. 2 Hines, F.A. 3 Solomon, T. 4 Turkleson, J. 4 Berry, D. 5 Dick, H. 5 Wilson, F. 5 Khan, M.A. 1; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicological Research and Nutritional Product Studies, Muirkirk Research Center, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Division of Mathematics, 5100 Paint Branch Parkway, College Park, MD 20740, USA 3: Office of Scientific Analysis and Support, 5100 Paint Branch Parkway, College Park, MD 20740, USA 4: Veterans Administration, Kansas City, MO 64108, USA 5: US Department of Agriculture, Western Regional Research Laboratory, Albany, CA 94710, USA; Source Info: Apr2002, Vol. 40 Issue 4, p501; Subject Term: PATHOLOGY; Subject Term: CLINICAL chemistry; Subject Term: PLASMA chemistry; Subject Term: CHOLECYSTOKININ; Author-Supplied Keyword: analysis of variance (ANOVA); Author-Supplied Keyword: Autosow control group (ASC); Author-Supplied Keyword: Autosow trypsin inhibitor group (ASTI); Author-Supplied Keyword: blood urea nitrogen (BUN); Author-Supplied Keyword: Center for Food Safety and Applied Nutrition (CFSAN); Author-Supplied Keyword: cholecystokinin (CCK); Author-Supplied Keyword: deoxyribonucleic acid (DNA); Author-Supplied Keyword: ethylenediaminetetraacetic acid (EDTA); Author-Supplied Keyword: extramedullary hematopoiesis (EMH); Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: gamma-glutamyl transpeptidase (GGTP); Author-Supplied Keyword: gastrin releasing peptide (GRP); Author-Supplied Keyword: lactate dehydrogenase (LDH); Author-Supplied Keyword: least squares mean (LSM); Author-Supplied Keyword: liquid test diet (LTD); Author-Supplied Keyword: mean corpuscular hemoglobin (MCH); Author-Supplied Keyword: mean corpuscular hemoglobin concentration (MCHC); Author-Supplied Keyword: mean corpuscular volume (MCV); Author-Supplied Keyword: ornithine decarboxylase (ODC); Author-Supplied Keyword: red cell distribution width (RCDW); Author-Supplied Keyword: ribonucleic acid (RNA); Author-Supplied Keyword: serum glutamic–oxaloacetic transaminase (SGOT); Author-Supplied Keyword: serum glutamic–pyruvic transaminase (SGPT); Author-Supplied Keyword: sow control (SC); Author-Supplied Keyword: trypsin inhibitor. (TI); Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Palmai, M.
AU - Buchanan, R. L.
T1 - Growth of Listeria monocytogenes during germination of alfalfa sprouts
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2002/04//
VL - 19
IS - 2/3
M3 - Article
SP - 195
SN - 07400020
AB - A large number of micro-organisms are able to proliferate on sprouts. The microflora may occasionally contain pathogenic bacteria that can be a source of outbreaks. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPROUTS
KW - PATHOGENIC microorganisms
N1 - Accession Number: 7923072; Palmai, M. 1 Buchanan, R. L. 2; Affiliation: 1: Campden and Chorleywood Food Industry Development Institute, Hungary 2: US Food and Drug Administration, Center for Food Safety and Nutrition, FSI, 200 C Street, SW, Washington, DC, 20204, USA; Source Info: Apr2002, Vol. 19 Issue 2/3, p195; Subject Term: SPROUTS; Subject Term: PATHOGENIC microorganisms; Number of Pages: 6p; Document Type: Article
L3 - 10.1006/fmic.2001.0470
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Rickie R.
AU - Murphy, William J.
AU - Snawder, John E.
AU - Striley, Cynthia A.F.
AU - Henderson, Donald
AU - Khan, Amir
AU - Krieg, Edward F.
T1 - Susceptibility to the ototoxic properties of toluene is species specific
JO - Hearing Research
JF - Hearing Research
Y1 - 2002/04//
VL - 166
IS - 1/2
M3 - Article
SP - 24
SN - 03785955
AB - Toluene is the most widely used industrial solvent. It has been shown to be ototoxic in mice and rats, and to increase permanent threshold shift in conjunction with exposure to noise. Chinchillas are widely used for studying noise effects on the cochlea. The present study was initiated to study toluene and noise interaction in chinchillas. Thirty-three chinchillas were exposed to a 95 dBA 500 Hz octave band noise plus 2000 ppm toluene, 8 or 12 h per day for 10 days. Auditory function was estimated using the auditory brainstem response (ABR) to tones between 500 Hz and 16 kHz. There was no effect on the ABR of toluene alone. Noise alone produced a threshold shift. There was no interaction of noise and toluene on the ear. The present study suggests that chinchillas are markedly less susceptible to the ototoxic effect of toluene than mice and rats. A working hypothesis as to the species differences was that chinchilla liver was able to detoxify the toluene. Hepatic microsomes from chinchillas, rats and humans were tested for their ability to convert toluene to the more water-soluble compound – benzyl alcohol. Chinchilla livers were found to contain more of the P450 enzymes CYP2E1 and CYP2B than rats or humans. In addition, the data show that the P450 enzymes are more active in chinchillas than in rats and humans. In conclusion, the results suggest that rats and mice are a more appropriate model for human toluene ototoxicity. However, chinchillas may provide a valuable model for investigating how ototoxic agents can be detoxified to less damaging compounds. [Copyright &y& Elsevier]
AB - Copyright of Hearing Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOLUENE
KW - OTOTOXIC agents
KW - Chinchilla
KW - CYP2B
KW - CYP2E1
KW - Hepatic microsome
KW - Ototoxicity
KW - Toluene
N1 - Accession Number: 7823279; Davis, Rickie R. 1,2; Email Address: rrd1@cdc.gov Murphy, William J. 1 Snawder, John E. 3 Striley, Cynthia A.F. 3 Henderson, Donald 4 Khan, Amir 5 Krieg, Edward F. 6; Affiliation: 1: Hearing Loss Prevention Section, Engineering and Physical Hazards Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA 3: Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 4: Hearing Research Laboratory, State University of New York, Buffalo, NY, USA 5: Control Technology Section, Engineering and Physical Hazards Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 6: Monitoring Research and Statistics Activity, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Apr2002, Vol. 166 Issue 1/2, p24; Subject Term: TOLUENE; Subject Term: OTOTOXIC agents; Author-Supplied Keyword: Chinchilla; Author-Supplied Keyword: CYP2B; Author-Supplied Keyword: CYP2E1; Author-Supplied Keyword: Hepatic microsome; Author-Supplied Keyword: Ototoxicity; Author-Supplied Keyword: Toluene; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wasserman, Donald E.
AU - Hudock, Stephen D.
AU - Wasserman, Jack F.
AU - Mullinix, Logan
AU - Wurzelbacher, Steven J.
AU - Siegfried, Karl V.
T1 - Hand–arm vibration in a group of hand-operated grinding tools.
JO - Human Factors & Ergonomics in Manufacturing
JF - Human Factors & Ergonomics in Manufacturing
Y1 - 2002///Spring2002
VL - 12
IS - 2
M3 - Article
SP - 211
EP - 226
SN - 10908471
AB - Vibration acceleration was triaxially and basicentrically measured, and digital-audio-tape-recorded with each axis separately evaluated using both the ANSI S3.34 and ACGIH hand-arm vibration (HAV) guidelines, for two pairs of pneumatic handheld grinders commonly used in metal fabrication operations including shipyards. Each tool pair consisted of a new and used grinder of the same model, performing the same simulated grinding tasks using new small grinding wheels, carbide burrs, wire brushes, and flap wheels. The results of this limited study showed, primarily, that the HAV standards were not exceeded, but there was a consistent tendency for the acceleration levels to increase between new and used tools, ranging from 11% to 66% on the Z-axis, 13% to 66% on the Y-axis, 44% to 58% on the X-axis, when tasks involved using grinding wheels and carbide burrs (hard implements). The results were mixed when using disposable wire brushes and flap wheels (softer implements). The overall results suggest the need for and implementation of a regular tool vibration monitoring and maintenance program as a primary element to help maintain tool acceleration levels to a minimum. © 2002 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors & Ergonomics in Manufacturing is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERGONOMICS
KW - VIBRATION (Mechanics)
KW - GRINDING machines
KW - OSCILLATIONS
KW - TOOLS
N1 - Accession Number: 13361391; Wasserman, Donald E. 1 Hudock, Stephen D. 2 Wasserman, Jack F. 1 Mullinix, Logan 1 Wurzelbacher, Steven J. 2 Siegfried, Karl V. 3; Affiliation: 1: Institute for the Study of Human Vibration, University of Tennessee Engineering School, Knoxville, TN 37996-2030, U.S.A. 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, U.S.A. 3: MEMIC Safety Services, Portland, ME 04104, U.S.A.; Source Info: Spring2002, Vol. 12 Issue 2, p211; Subject Term: ERGONOMICS; Subject Term: VIBRATION (Mechanics); Subject Term: GRINDING machines; Subject Term: OSCILLATIONS; Subject Term: TOOLS; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; Number of Pages: 16p; Illustrations: 2 Black and White Photographs, 3 Diagrams, 8 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/hfm.10009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kumar, Sanjai
AU - Villinger, Francois
AU - Oakley, Miranda
AU - Aguiar, Joao C.
AU - Jones, Trevor R.
AU - Hedstrom, Richard C.
AU - Gowda, Kalpana
AU - Chute, John
AU - Stowers, Anthony
AU - Kaslow, David C.
AU - Thomas, Elaine K.
AU - Tine, John
AU - Klinman, Dennis
AU - Hoffman, Stephen L.
AU - Weiss, Walter W.
T1 - A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-γ and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulating factor
JO - Immunology Letters
JF - Immunology Letters
Y1 - 2002/04//
VL - 81
IS - 1
M3 - Article
SP - 13
SN - 01652478
AB - We have constructed a DNA plasmid vaccine encoding the C-terminal 42-kDa region of the merozoite surface protein1 (pMSP142) from the 3D7 strain of Plasmodium falciparum (Pf3D7). This plasmid expressed recombinant MSP142 after in vitro transfection in mouse VM92 cells. Rhesus monkeys immunized with pMSP142 produced antibodies reactive with Pf3D7 infected erythrocytes by IFAT, and by ELISA against yeast produced MSP119 (yMSP119). Immunization also induced antigen specific T cell responses as measured by interferon-γ production, and by classical CTL chromium release assays. In addition, immunization with pMSP142 primed animals for an enhanced antibody response to a subsequent boost with the recombinant yMSP119. We also evaluated Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) as an adjuvant for pMSP142. We tested both rhesus GM-CSF expressed from a DNA plasmid, and E. coli produced recombinant human GM-CSF. Plasmids encoding rhesus GM-CSF (prhGM-CSF) and human GM-CSF (phuGM-CSF) were constructed; these plasmids expressed bio-active recombinant GMCSF. Co-immunization with a mixture of prhGM-CSF and pMSP142 induced higher specific antibody responses after the first dose of plasmid, but after three doses of DNA monkeys immunized with or without prhGM-CSF had the same final antibody titers and T cell responses. In comparison, rhuGM-CSF protein did not lead to accelerated antibody production after the first DNA dose. However, antibody titers were maintained at a slightly higher level in monkeys receiving GM-CSF protein, and they had a higher response to boosting with recombinant MSP119. The GM-CSF plasmid or protein appears to be less potent as an adjuvant in rhesus monkeys than each is in mice, and more work is needed to determine if GM-CSF can be a useful adjuvant in DNA vaccination of primates. [Copyright &y& Elsevier]
AB - Copyright of Immunology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA vaccines
KW - PLASMODIUM falciparum
KW - T cells
KW - RHESUS monkey
KW - INTERFERONS
KW - Cytotoxic T cells (CTL)
KW - DNA vaccine
KW - Interferon-γ (IFN-γ)
KW - Merozoite surface protein 1 (MSP1)
KW - Plasmodium falciparum
KW - Rhesus monkey
N1 - Accession Number: 7754276; Kumar, Sanjai 1,2; Email Address: kumars@nmrc.navy.mil Villinger, Francois 3 Oakley, Miranda 1 Aguiar, Joao C. 1 Jones, Trevor R. 1 Hedstrom, Richard C. 1 Gowda, Kalpana 1 Chute, John 4 Stowers, Anthony 5 Kaslow, David C. 5 Thomas, Elaine K. 6 Tine, John 7 Klinman, Dennis 8 Hoffman, Stephen L. 1 Weiss, Walter W. 1; Affiliation: 1: Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA 2: Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA 3: Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30333, USA 4: Stem Cell Biology Section, NIDDK/Navy Transplantation and Autoimmunity Branch, Bethesda, MD 20889, USA 5: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA 6: Immunex Corp, Seattle, WA 98101, USA 7: Virogenetics Corporation, Troy, NY 12180, USA 8: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2002, Vol. 81 Issue 1, p13; Subject Term: DNA vaccines; Subject Term: PLASMODIUM falciparum; Subject Term: T cells; Subject Term: RHESUS monkey; Subject Term: INTERFERONS; Author-Supplied Keyword: Cytotoxic T cells (CTL); Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: Interferon-γ (IFN-γ); Author-Supplied Keyword: Merozoite surface protein 1 (MSP1); Author-Supplied Keyword: Plasmodium falciparum; Author-Supplied Keyword: Rhesus monkey; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Ye, Jianping
AU - Ma, Jane
AU - Barger, Mark
AU - Robinson, Victor A.
AU - Ramsey, Dawn
AU - McLaurin, Jeff
AU - Khan, Amir
AU - Landsittel, Douglas
AU - Teass, Alexander
AU - Castranova, Vincent
T1 - TIME COURSE OF PULMONARY RESPONSE OF RATS TO INHALATION OF CRYSTALLINE SILICA: NF-κB ACTIVATION, INFLAMMATION, CYTOKINE PRODUCTION, AND DAMAGE.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2002/04//
VL - 14
IS - 4
M3 - Article
SP - 349
EP - 367
PB - Taylor & Francis Ltd
SN - 08958378
AB - In vitro studies suggest that silica-induced lung disease may be linked to processes regulated by nuclear factor-κB (NF-κB) activation, but this has not been examined in vivo. Rats were exposed to a silica aerosol of 15 mg/m[sup 3] (6 h/day, 5 days/wk) for 116 days, and bronchoalveolar lavage (BAL) was conducted at various times during the exposure. Silica-induced pulmonary inflammation and damage were determined by measuring BAL cell differentials and first BAL fluid lactate dehydrogenase (LDH) activity and serum albumin concentrations, respectively. NF-κB activation and production of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) by BAL cells were also measured. The results demonstrate that NF-κB activation occurred after 5 days exposure, and continued to increase thereafter. BAL cell production of IL-1 and TNF-α had increased incrementally by 10 and 30 days of exposure, respectively. This elevation continued through 79 days of exposure before further increasing at 116 days of exposure. Pulmonary inflammation and damage in silica-exposed rats were also significantly elevated at 5 days of exposure, further increased at a slow rate through 41 days of exposure, and dramatically increased thereafter. Taken together, the results indicate that the initial molecular response of NF-κB activation in BAL cells occurs in response to low levels of silica deposition in the lung and increases more rapidly versus exposure duration than silica-induced pulmonary inflammation, cellular damage, and cytokine production by BAL cells. This suggests that NF-κB activation in BAL cells may play an important role in the initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNG diseases
KW - INFLAMMATION
KW - BRONCHOALVEOLAR lavage
N1 - Accession Number: 6476276; Porter, Dale W. 1 Ye, Jianping 1 Ma, Jane 1 Barger, Mark 1 Robinson, Victor A. 1 Ramsey, Dawn 2 McLaurin, Jeff 2 Khan, Amir 2 Landsittel, Douglas 1 Teass, Alexander 2 Castranova, Vincent 1; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio, USA; Source Info: Apr2002, Vol. 14 Issue 4, p349; Subject Term: LUNG diseases; Subject Term: INFLAMMATION; Subject Term: BRONCHOALVEOLAR lavage; Number of Pages: 19p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/08958370252870998
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Couch, L. H
AU - Howard, P. C
T1 - Quantification of glycolic acid in cosmetic products using reversed phase high performance liquid chromatography.
JO - International Journal of Cosmetic Science
JF - International Journal of Cosmetic Science
Y1 - 2002/04//
VL - 24
IS - 2
M3 - Article
SP - 89
EP - 95
PB - Wiley-Blackwell
SN - 01425463
AB - Many cosmetics contain keratolytic hydroxy acids to correct the effects of photoageing on human skin. Although methods exist for quantifying the α-hydroxy acid, glycolic acid in aqueous media, accurate methods for quantification in mixed hydrophobic and aqueous cosmetic creams and lotions are lacking. Glycolic acid was extracted from cosmetics using aqueous tetrahydrofuran (THF), separated with strong-anion exchange cartridges, and quantified by high performance liquid chromatography (HPLC) with UV–VIS detection without the paired-ion reagents. In a recovery experiment, the mean accuracy of the method was 100.6%. The dynamic range of the method allows for the detection of glycolic acid at concentrations used in over-the-counter cosmetics. (English) [ABSTRACT FROM AUTHOR]
AB - De nombreux produits cosmétiques contiennent des alpha-hydroxy-acides kératolytiques afin de corriger les effets du photo – vieillissement de la peau humaine. Si de nombreuses méthodes de dosage des alpha hydroxy-acides en milieu aqueux existent, les méthodes de quantification précise dans des milieux mixtes, hydrophobes et aqueux, crèmes ou lotions, manquent. L'acide Glycolique a été extrait des produits cosmétiques à l'aide de tetra-hydrofuranne, séparé par des cartouches d'échange anionique fort, puis quantifié par HPLC coupléà détection UV–VIS sans adjonction de réactifs ions-appariés. Une détermination du rendement de la méthode indique, comme précision moyenne de celle-ci, une valeur de 100.6%. L'échelle dynamique de la méthode permet la détection de l'acide glycolique aux concentrations utilisées dans les produits cosmétiques OTC. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Cosmetic Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - COSMETICS
KW - ALPHA-HYDROXY ACID
KW - cosmetics
KW - extraction
KW - glycolic acid
KW - HPLC
N1 - Accession Number: 6613075; Couch, L. H 1 Howard, P. C 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Apr2002, Vol. 24 Issue 2, p89; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: COSMETICS; Author-Supplied Keyword: ALPHA-HYDROXY ACID; Author-Supplied Keyword: cosmetics; Author-Supplied Keyword: extraction; Author-Supplied Keyword: glycolic acid; Author-Supplied Keyword: HPLC; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 0p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1046/j.1467-2494.2002.00128.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Suner, Selim
AU - Jay, Gregory D.
AU - Kleinman, Gary J.
AU - Woolard, Robert H.
AU - Jagminas, Liudvikas
AU - Becker, Bruce M.
T1 - Cardiopulmonary resuscitation using the cardio vent device in a resuscitation model1,2 1 None of the authors have any financial relationship with the manufacturers or distributors of the device used in this study.2 Original Contributions is coordinated by John Marx, MD, of Carolinas Medical Center, Charlotte, North Carolina1 Selected Topics: Toxicology is coordinated by Kenneth Kulig, md, of Denver, Coloradoβ -synthase
JO - Molecular Genetics & Metabolism
JF - Molecular Genetics & Metabolism
Y1 - 2002/04//
VL - 75
IS - 4
M3 - Article
SP - 335
SN - 10967192
AB - Elevated plasma homocysteine is associated with a variety of diseases in humans including coronary heart disease, stroke, peripheral vascular disease, and birth defects. However, the mechanism by which plasma homocysteine affects cells is unknown. We have examined the growth of isogenic wild-type and cystathionine β -synthase (CBS) deficient yeast in response to homocysteine and its immediate metabolic precursor, S-adenosylhomocysteine (SAH). CBS deficient yeast export significantly more homocysteine into the media than wild-type yeast and have elevated internal pools of homocysteine and SAH. We found that 5 mM homocysteine added to the media had very little effect on the growth of wild-type or CBS deficient yeast, although intracellular homocysteine concentrations increased five- to tenfold. In contrast, as little as 25 μM S-adenosylhomocysteine inhibited the growth of CBS deficient yeast, but had no effect on wild-type yeast. Measurements of the intracellular S-adenosylmethionine (SAM) and SAH indicate that CBS deficient yeast contain reduced SAM/SAH ratios relative to wild-type, and this ratio is further reduced by adding SAH to the media. Growth inhibition by SAH in CBS deficient yeast can be totally reversed by addition of SAM to the media, indicating that the ratio and not absolute level is critical for cell growth. These results suggest that CBS plays a key role in the regulation of the SAM/SAH ratio inside cells and that excessive perturbations of this ratio can inhibit growth. We hypothesize that elevated extracellular homocysteine present in humans may reflect an altered intracellular SAM/SAH ratio and that this may be related to disease pathogenesis. [Copyright &y& Elsevier]
AB - Copyright of Molecular Genetics & Metabolism is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOMOCYSTEINE
KW - YEAST
N1 - Accession Number: 8504165; Christopher, Scott A. 1 Melnyk, Stepan 2 Jill James, S. 2 Kruger, Warren D. 1; Email Address: wd_kruger@fccc.edu; Affiliation: 1: Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA 2: Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Apr2002, Vol. 75 Issue 4, p335; Subject Term: HOMOCYSTEINE; Subject Term: YEAST; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meier, Kristen L.
T1 - Reporting results from studies evaluating diagnostic tests
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
Y1 - 2002/04/15/
VL - 24
IS - 8
M3 - Article
SP - 60
SN - 01964399
AB - Evaluating a new diagnostic test requires careful planning. It involves choosing the appropriate comparative procedure, patients, specimens, and individuals performing the tests. The type of study design used to evaluate a new test has a direct impact on how the study results can be reported. This article describes some statistically appropriate and inappropriate practices for reporting results from different studies evaluating qualitative diagnostic tests. Special attention is given to describing a practice called discrepant resolution and its associated problems. [Copyright &y& Elsevier]
AB - Copyright of Clinical Microbiology Newsletter is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSIS
KW - MEDICAL research -- Evaluation
N1 - Accession Number: 7822816; Meier, Kristen L. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, USA; Source Info: Apr2002, Vol. 24 Issue 8, p60; Subject Term: DIAGNOSIS; Subject Term: MEDICAL research -- Evaluation; Number of Pages: 4p; Document Type: Article
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ER -
TY - JOUR
AU - Johnson, Elizabeth Anne
AU - O’Callaghan, James P.
AU - Miller, Diane B.
T1 - Chronic treatment with supraphysiological levels of corticosterone enhances d-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse
JO - Brain Research
JF - Brain Research
Y1 - 2002/04/19/
VL - 933
IS - 2
M3 - Article
SP - 130
SN - 00068993
AB - Chronic stress and extended periods of elevated circulating glucocorticoids have been reported to exacerbate excitotoxicity-induced hippocampal neuronal injury in rat. Despite continued interest in the effects of protracted exposure to stress or glucocorticoids, there has been little examination of how other types of neurotoxicity may be exacerbated or blocked, by stress. Here we examined the effects of chronic supraphysiologic levels of corticosterone on d-3,4-methylenedioxymethamphetamine (d-MDMA)-induced striatal dopaminergic neurotoxicity in the female C57BL/6J mouse. Corticosterone (5 mg, 15 mg or placebo) pellets were implanted to continuously elevate circulating glucocorticoids and create a model of the ultimate effect of chronic activation of the hypothalamic–pituitary–adrenal axis. After 7 days, a neurotoxic regimen of d-MDMA was administered (20 mg/kg s.c. every 2 h×4); thymus, spleen, striatum and hippocampus were collected 72 h later. Significant involution of thymus and spleen confirmed the bioavailability of the corticosterone at both dosages. d-MDMA increased the striatal levels of the astrocyte-localized protein glial fibrillary acidic protein (GFAP, a marker of gliosis); both dosages of corticosterone exacerbated this increase but only the 15 mg pellet exacerbated the decrease in tyrosine hydroxylase protein. Corticosterone alone or in combination with d-MDMA produced no neural injury in hippocampus, as measured by GFAP. Our work indicates corticosterone was able to increase the vulnerability of the striatum, but not the hippocampus to d-MDMA. An examination of other mouse strains and models of neurotoxic injury would be useful in determining the general validity of the glucocorticoid neuroendangerment hypothesis. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRAIN -- Wounds & injuries
KW - GLUCOCORTICOIDS
KW - d-MDMA
KW - Dopamine
KW - Hippocampus
KW - HPA axis
KW - Serotonin
KW - Striatum
N1 - Accession Number: 7775954; Johnson, Elizabeth Anne; Email Address: edj2@cdc.gov O’Callaghan, James P. 1 Miller, Diane B. 1; Affiliation: 1: Chronic Stress and Molecular Neurotoxicology Laboratories, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health/Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Apr2002, Vol. 933 Issue 2, p130; Subject Term: BRAIN -- Wounds & injuries; Subject Term: GLUCOCORTICOIDS; Author-Supplied Keyword: d-MDMA; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Hippocampus; Author-Supplied Keyword: HPA axis; Author-Supplied Keyword: Serotonin; Author-Supplied Keyword: Striatum; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schwerha, Diana J.
AU - Orr, Chun-Sing
AU - Chen, Bean T.
AU - Soderholm, Sidney C.
T1 - Direct-on-filter analysis of crystalline silica using photoacoustic Fourier transform-infrared spectroscopy
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2002/04/22/
VL - 457
IS - 2
M3 - Article
SP - 257
SN - 00032670
AB - Photoacoustic Fourier transform-infrared spectroscopy (PA-FT-IR) has been used to perform direct-on-filter (DOF) analysis of crystalline silica using laboratory-generated filter samples. With these samples, the silica particles were embedded in the stable three-dimensional matrix of the filter. In this preliminary study, it was demonstrated that the photoacoustic (PA) signals generated from direct-on-filter measurements were significantly higher than the corresponding signals for equivalent amounts of silica particles placed directly in the photoacoustic detector cup. Studies with Min-U-Sil-5 loaded onto 9 mm filter stubs indicated a limit of detection of less than 10 μg. Additionally, Teflon filters were demonstrated to be more suitable for these measurements than other types. The photoacoustic FT-IR approach seems to be feasible for further development to use with full-sized personal sampling filters. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOURIER transform infrared spectroscopy
KW - SILICA
KW - PHOTOACOUSTIC spectroscopy
KW - Crystalline silica
KW - FT-IR
KW - Personal exposure
KW - Photoacoustic spectroscopy
N1 - Accession Number: 7775253; Schwerha, Diana J. 1 Orr, Chun-Sing; Email Address: corr@cdc.gov Chen, Bean T. 1 Soderholm, Sidney C. 1; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 3030, Morgantown, WV 26505, USA; Source Info: Apr2002, Vol. 457 Issue 2, p257; Subject Term: FOURIER transform infrared spectroscopy; Subject Term: SILICA; Subject Term: PHOTOACOUSTIC spectroscopy; Author-Supplied Keyword: Crystalline silica; Author-Supplied Keyword: FT-IR; Author-Supplied Keyword: Personal exposure; Author-Supplied Keyword: Photoacoustic spectroscopy; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gao, Pengfei
AU - Chen, Bean T.
AU - Baron, Paul A.
AU - Soderholm, Sidney C.
T1 - A Numerical Study of the Performance of an Aerosol Sampler with a Curved, Blunt, Multi-Orificed Inlet.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2002/05//
VL - 36
IS - 5
M3 - Article
SP - 540
EP - 553
SN - 02786826
AB - The purpose of this study was to numerically simulate the performance of an aerosol sampler with a curved, blunt, multi-orificed inlet in order to understand the sampling characteristics of the first prototype of the button personal inhalable aerosol sampler ("button sampler"). Because the button sampler inlet design is too complicated to apply a three-dimensional model, an axisymmetric two-dimensional model was created to be similar in geometry and to simulate the major features of the airflow through the sampler when facing the wind. Particle trajectories were calculated in a variety of wind velocities and were categorized into 5 groups based on their interactions with the curved surface of the sampling plane. Empirical sampling efficiencies of the button sampler for 3 particle sizes were used to adjust the calculated sampling efficiencies in an attempt to improve the accuracy of the two-dimensional axisymmetric model in accounting for interactions between particles and the surface of the inlet of the button sampler. Sampling efficiencies for other particle sizes were then predicted. The results showed that sampling efficiency decreased with increasing particle size up to approximately 40 μm and then remained virtually unchanged at about 35% up to 100 μm. Although the efficiencies were lower than the American Conference of Governmental Industrial Hygienists' (ACGIH) inhalability curve for larger particles, the pattern of the predicted sampling efficiency was quite similar to the ACGIH inhalability curve. Sampling efficiencies for liquid aerosol particles larger than 15 μm were predicted to be noticeably lower than those for solid particles. The results also showed that the multi-orificed curved surface played an important role in establishing a pressure drop with desired flow alignment inside the sampler, thus greatly reducing the wind effect and significantly improving the uniformity of particle deposition on the filter. The less uniform deposition found at high wind velocity can be improved by increasing the sampling flow rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - AIR flow
KW - INLETS
N1 - Accession Number: 6510882; Gao, Pengfei 1 Chen, Bean T. 1 Baron, Paul A. 2 Soderholm, Sidney C. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: May2002, Vol. 36 Issue 5, p540; Subject Term: AEROSOLS (Sprays); Subject Term: AIR flow; Subject Term: INLETS; Number of Pages: 14p; Illustrations: 16 Diagrams, 8 Graphs; Document Type: Article
L3 - 10.1080/02786820252883784
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baron, Paul A.
AU - Bennett, James S.
T1 - Calculation of Leakage and Particle Loss in Filter Cassettes.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2002/05//
VL - 36
IS - 5
M3 - Article
SP - 632
EP - 641
SN - 02786826
AB - Experimental evidence of aerosol bypass leakage around the filter in plastic filter cassettes prompted an investigation using computational fluid dynamics to explain particle penetration through the leak. Axi-symmetric models of a cassette with several leak dimensions were constructed. The models predicted that submicrometer particles penetrated the leak, but that larger particles impacted on the filter surface. Experimental data from another study clearly indicated that larger solid particles were being lost from the surface of the filter during sampling. When particle bounce was invoked as an explanation for this loss of sampled solid particles, the theoretical loss from the filter in cassettes with large leaks exhibited characteristics similar to the experimental data. For small leaks, the mass loss behavior appeared to be more complex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - FILTERS & filtration
KW - FLUID dynamics
N1 - Accession Number: 6510891; Baron, Paul A. 1 Bennett, James S. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: May2002, Vol. 36 Issue 5, p632; Subject Term: AEROSOLS (Sprays); Subject Term: FILTERS & filtration; Subject Term: FLUID dynamics; Number of Pages: 10p; Illustrations: 9 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/02786820252883865
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Stryer, Daniel B.
AU - Clancy, Carolyn
T1 - Disparities in hospital transfer: inequities, patient-centered care, or both?
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 2002/05//
VL - 112
IS - 7
M3 - Editorial
SP - 580
SN - 00029343
N1 - Accession Number: 7804783; Stryer, Daniel B. 1 Clancy, Carolyn 1; Affiliation: 1: From the Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, Maryland, USA; Source Info: May2002, Vol. 112 Issue 7, p580; Number of Pages: 2p; Document Type: Editorial
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ER -
TY - JOUR
AU - Estill, Cheryl Fairfield
AU - Watkins, Daniel S.
AU - Hall, Ronald M.
AU - O'Brien, Dennis M.
AU - Shulman, Stanley A.
T1 - The Impact of Maintenance and Design for Ventilation Systems.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 344
EP - 351
SN - 1047322X
AB - Ventilation systems need to be designed to include access for cleaning and preventive maintenance. Without such access, the exhaust volume will deteriorate. Because of access difficulties and the many demands on their time, plant managers are sometimes errant in performing proper preventive maintenance. Three surveys measuring workers' exposures to methylene chloride were conducted at the same furniture stripping facility. A new ventilation system was installed for the first survey, resulting in an exhaust volume of 2900 cfm and worker exposure to methylene chloride of 59 ppm (geometric mean). Immediately after the first survey, the gasoline-powered fan was replaced by a smaller capacity electrically powered fan. Deterioration in the ventilation system was seen after seven years. Problems included clogged slots, paint chips and sawdust deposits in plenums, and a loose and frayed fan belt. The second survey indicated a reduction in exhaust volume to 1060 cfm and increased worker exposure to 330 ppm. With the smaller capacity fan still in place, the system was otherwise upgraded to allow for easier access and maintenance was performed. The third survey showed that the ventilation system performance was better (exhaust volume improved to 2080 cfm)and the worker exposures were reduced to 73 ppm. This study shows the benefits of designing for preventive maintenance and the necessity of keeping the ventilation systems clean. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VENTILATION -- Design & construction
KW - CLEANING
KW - UNITED States
KW - DIP TANK
KW - ENGINEERING
KW - FURNITURE STRIPPING
KW - METHYLENE CHLORIDE
KW - occupation
KW - SIC 7641
KW - Small business
KW - Ventilation
N1 - Accession Number: 6472396; Estill, Cheryl Fairfield 1 Watkins, Daniel S. 1 Hall, Ronald M. 1 O'Brien, Dennis M. 1 Shulman, Stanley A. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: May2002, Vol. 17 Issue 5, p344; Subject Term: VENTILATION -- Design & construction; Subject Term: CLEANING; Subject Term: UNITED States; Author-Supplied Keyword: DIP TANK; Author-Supplied Keyword: ENGINEERING; Author-Supplied Keyword: FURNITURE STRIPPING; Author-Supplied Keyword: METHYLENE CHLORIDE; Author-Supplied Keyword: occupation; Author-Supplied Keyword: SIC 7641; Author-Supplied Keyword: Small business; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 561720 Janitorial Services; Number of Pages: 8p; Illustrations: 4 Black and White Photographs, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10473220252864941
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Earnest, G. Scott
T1 - A Control Technology Evaluation of State-of-the-Art, Perchloroethylene Dry-Cleaning Machines.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 352
EP - 359
SN - 1047322X
AB - NIOSH researchers evaluated the ability of fifthgeneration dry-cleaning machines to control occupational exposure to perchloroethylene (PERC). Use of these machines is mandated in some countries; however, less than 1 percent of all U.S. shops have them. A study was conducted at a U.S. dry-cleaning shop where two fifth-generation machines were used. Both machines had a refrigerated condenser as a primary control and a carbon adsorber as a secondary control to recover PERC vapors during the dry cycle. These machines were designed to lower the PERC concentration in the cylinder at the end of the dry cycle to below 290 ppm. A single-beam infrared photometer continuously monitors the PERC concentration in the machine cylinder, and a door interlock prevents opening until the concentration is below 290 ppm. Personal breathing zone air samples were measured for the machine operator and presser. The operator had time-weighted average (TWA) PERC exposures that were less than 2 ppm. Highest exposures occurred during loading and unloading the machine and when performing routine machine maintenance. All presser samples were below the limit of detection. Real-time video exposure monitoring showed that the operator had peak exposures near 160 ppm during loading and unloading the machine (below the OSHA maximum of 300 ppm). This exposure (160 ppm) is an order of magnitude lower than exposures with more traditional machines that are widely used in the United States. The evaluated machines were very effective at reducing TWA PERC exposures as well as peak exposures that occur during machine loading and unloading. State-of-the-art dry-cleaning machines equipped with refrigerated condensers, carbon adsorbers, drum monitors, and door interlocks can provide substantially better protection than more traditional machines that are widely used in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRY cleaning machines
KW - TETRACHLOROETHYLENE
KW - INDUSTRIAL hygiene
KW - UNITED States
KW - Dry cleaning
KW - Engineering controls
KW - Exposure reduction
KW - PERCHLOROETHYLENE
KW - Technical feasibility
KW - Tetrachloroethylene
KW - Vapor recovery
N1 - Accession Number: 6472395; Earnest, G. Scott 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio; Source Info: May2002, Vol. 17 Issue 5, p352; Subject Term: DRY cleaning machines; Subject Term: TETRACHLOROETHYLENE; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; Author-Supplied Keyword: Dry cleaning; Author-Supplied Keyword: Engineering controls; Author-Supplied Keyword: Exposure reduction; Author-Supplied Keyword: PERCHLOROETHYLENE; Author-Supplied Keyword: Technical feasibility; Author-Supplied Keyword: Tetrachloroethylene; Author-Supplied Keyword: Vapor recovery; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 333310 Commercial and service industry machinery manufacturing; NAICS/Industry Codes: 417920 Service establishment machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333318 Other Commercial and Service Industry Machinery Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10473220252864950
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klingner, Thomas D.
AU - Boeniger, Mark F.
T1 - A Critique of Assumptions About Selecting Chemical-Resistant Gloves: A Case for Workplace Evaluation of Glove Efficacy.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 360
EP - 367
SN - 1047322X
AB - Wearing chemical-resistant gloves and clothing is the primary method used to prevent skin exposure to toxic chemicals in the workplace. The process for selecting gloves is usually based on manufacturers' laboratory-generated chemical permeation data. However, such data may not reflect conditions in the workplace where many variables are encountered (e.g., elevated temperature, flexing, pressure, and product variation between suppliers). Thus, the reliance on this selection process is questionable. Variables that may influence the performance of chemical-resistant gloves are identified and discussed. Passive dermal monitoring is recommended to evaluate glove performance under actual-use conditions and can bridge the gap between laboratory data and real-world performance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLOVES
KW - HAZARDOUS substances
KW - DESIGN
KW - UNITED States
KW - Chemical protection
KW - CHEMICAL-RESISTANT GLOVES
KW - GLOVE PERFORMANCE
KW - Occupational
KW - Skin protection
N1 - Accession Number: 6472406; Klingner, Thomas D. 1 Boeniger, Mark F. 2; Affiliation: 1: Colormetric Laboratories, Inc., Des Plaines, Illinois 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: May2002, Vol. 17 Issue 5, p360; Subject Term: GLOVES; Subject Term: HAZARDOUS substances; Subject Term: DESIGN; Subject Term: UNITED States; Author-Supplied Keyword: Chemical protection; Author-Supplied Keyword: CHEMICAL-RESISTANT GLOVES; Author-Supplied Keyword: GLOVE PERFORMANCE; Author-Supplied Keyword: Occupational; Author-Supplied Keyword: Skin protection; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1080/10473220252864969
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boeniger, Mark F.
AU - Klingner, Thomas D.
T1 - In-Use Testing and Interpretation of Chemical-Resistant Glove Performance.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/05//
VL - 17
IS - 5
M3 - Article
SP - 368
EP - 378
SN - 1047322X
AB - Issuing gloves to workers is the most common approach to protecting against skin contact with hazardous chemicals. Typically, glove materials are selected and duration of wear is estimated based on comparisons of laboratory test data. Those who select the glove materials often fail to verify their selections by testing the glove during actual use. This failure poses a common but potentially serious hazard to workers. Although methods are available for assessing permeation rates during actual use, such testing is unlikely without acceptable exposure guidance criteria for decision making. This document reviews methods for testing glove performance during actual use and suggests an approach for estimating acceptable exposure guidance criteria for evaluation of chemicals that are systemically absorbed. It is the authors' opinion that as of now an approach to estimating exposure criteria for chemical irritants and sensitizers may not be feasible. With available data resources, acceptable glove exposure criteria could be generated for use in assessing the risk of using specific gloves for handling many compounds in occupational settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLOVES
KW - SKIN
KW - HAZARDOUS substances
KW - DESIGN
KW - CHEMICAL-RESISTANT
KW - DOCUMENTATION
KW - DURATION OF USE
KW - Evaluation
KW - GLOVE PERFORMANCE
KW - Occupational
KW - PERMEATION RESISTANCE
N1 - Accession Number: 6472405; Boeniger, Mark F. 1 Klingner, Thomas D. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: CLI Inc., Des Plaines, Illinois; Source Info: May2002, Vol. 17 Issue 5, p368; Subject Term: GLOVES; Subject Term: SKIN; Subject Term: HAZARDOUS substances; Subject Term: DESIGN; Author-Supplied Keyword: CHEMICAL-RESISTANT; Author-Supplied Keyword: DOCUMENTATION; Author-Supplied Keyword: DURATION OF USE; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: GLOVE PERFORMANCE; Author-Supplied Keyword: Occupational; Author-Supplied Keyword: PERMEATION RESISTANCE; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/10473220252864978
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Looker, A.C.
AU - Dawson-Hughes, B.
AU - Calvo, M.S.
AU - Gunter, E.W.
AU - Sahyoun, N.R.
T1 - Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III
JO - BONE
JF - BONE
Y1 - 2002/05//
VL - 30
IS - 5
M3 - Article
SP - 771
SN - 87563282
AB - Subclinical vitamin D deficiency may be common in certain subgroups in the U.S., but to date vitamin D data from other groups in the population have not been available. We used serum 25-hydroxyvitamin D (25-OHD) data from 18,875 individuals examined in the Third National Health and Nutrition Examination Survey (NHANES III 1988–1994) to assess the vitamin D status of selected groups of the noninstitutionalized U.S. adolescent and adult population. Serum 25-OHD levels were measured by a radioimmunoassay kit (DiaSorin, Inc., Stillwater, MN; normal range 22.5–94 nmol/L). Because physical exams are performed in mobile vans in NHANES, data could not be collected in northern latitudes during the winter; instead data were collected in northern latitudes during summer and in southern latitudes in winter. To address this season-latitude aspect of the NHANES design, we stratified the sample into two seasonal subpopulations (winter/lower latitude and summer/higher latitude) before examining vitamin D status. Less than 1% of the winter/lower latitude subpopulation had vitamin D deficiency (25-OHD <17.5 nmol/L). However, the prevalence of vitamin D insufficiency in this group ranged from 1%–5% with 25-OHD <25 nmol/L to 25%–57% with 25-OHD <62.5 nmol/L, even though the median latitude for this subsample (32°N) was considerably lower than the latitude at which vitamin D is not synthesized during winter months (∽42°N). With the exception of elderly women, prevalence rates of vitamin D insufficiency were lower in the summer/higher latitude subpopulation (<1%–3% with 25-OHD <25 nmol/L to 21%–49% with 25-OHD <62.5 nmol/L). Mean 25-OHD levels were highest in non-Hispanic whites, intermediate in Mexican Americans, and lowest in non-Hispanic blacks. Our findings suggest that vitamin D deficiency is unlikely in the two seasonal subpopulations of noninstitutionalized adolescents and adults that can be validly assessed in NHANES III. However, vitamin D insufficiency is more common in these two seasonal subpopulations. Of particular interest is that insufficiency occurred fairly frequently in younger individuals, especially in the winter/lower latitude subsample. Our findings support continued monitoring of this vitamin in the U.S. population. [Copyright &y& Elsevier]
AB - Copyright of BONE is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN D deficiency
KW - SERUM
KW - VITAMINS
KW - Adolescents
KW - Adults
KW - Hypovitaminosis D
KW - Serum 25-hydroxyvitamin D
KW - Vitamin D status
N1 - Accession Number: 8787051; Looker, A.C. 1; Email Address: acl1@cdc.gov Dawson-Hughes, B. 2 Calvo, M.S. 3 Gunter, E.W. 4 Sahyoun, N.R. 5; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD, USA 2: USDA Human Research Center, Tufts University, Boston, MA, USA 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA 4: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA 5: Department of Food and Nutrition, University of Maryland, College Park, MD, USA; Source Info: May2002, Vol. 30 Issue 5, p771; Subject Term: VITAMIN D deficiency; Subject Term: SERUM; Subject Term: VITAMINS; Author-Supplied Keyword: Adolescents; Author-Supplied Keyword: Adults; Author-Supplied Keyword: Hypovitaminosis D; Author-Supplied Keyword: Serum 25-hydroxyvitamin D; Author-Supplied Keyword: Vitamin D status; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patterson, M. L
AU - Slater, J. E
T1 - Characterization and comparison of commercially available German and American cockroach allergen extracts1.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2002/05//
VL - 32
IS - 5
M3 - Article
SP - 721
EP - 727
PB - Wiley-Blackwell
SN - 09547894
AB - Summary Background In this study we examine the variability among unstandardized cockroach allergen extracts. Methods We obtained 24 aqueous and glycerinated cockroach allergen extracts from nine manufacturers. We used previously characterized cockroach extracts, E2-Cg and E2-Ca, as references. The modified ninhydrin assay was used to determine protein concentration of each extract. Relative potencies of extracts were determined by competition ELISA, using a human allergic serum pool. Bla g 1 and Bla g 2 levels of glycerinated German cockroach extracts were determined by ELISA using monoclonal antibodies. Extracts were also analysed by SDS-PAGE. Results Commercial cockroach allergen extracts had highly variable protein contents that were lower than the protein contents of the references. Electrophoretic data confirmed the presence of a variable number and intensity of protein bands in extracts among manufacturers. The relative potencies of the commercial extracts were between 10 and 782 BAU/mL for German cockroach and 10–250 BAU/mL for American cockroach. The mean Bla g 1 content of the commercial extracts was significantly lower than that of the reference (P = 0.001). The mean Bla g 2 content of the commercial extracts was higher than that of the E2-Cg reference but the Bla g 2 levels were more variable compared to Bla g 1. In glycerinated German cockroach extracts, protein concentrations, relative potencies and specific allergen levels were significantly correlated (P < 0.001). Conclusion Our tests indicate that commercially available cockroach allergen extracts are variable in protein content, electrophoretic banding patterns, relative potency and Bla g 2 levels. In glycerinated German cockroach extracts, protein concentrations, relative potencies and specific allergen levels were significantly correlated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - COCKROACHES
KW - allergen extract
KW - Allergen standardization
KW - American cockroach
KW - Bla g 1
KW - Bla g 2
KW - cockroach
KW - German cockroach
KW - reference
KW - relative potency
KW - total protein content
N1 - Accession Number: 6612976; Patterson, M. L 1 Slater, J. E 1; Affiliation: 1: Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Regulation and Research, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, USA; Source Info: May2002, Vol. 32 Issue 5, p721; Subject Term: ALLERGENS; Subject Term: COCKROACHES; Author-Supplied Keyword: allergen extract; Author-Supplied Keyword: Allergen standardization; Author-Supplied Keyword: American cockroach; Author-Supplied Keyword: Bla g 1; Author-Supplied Keyword: Bla g 2; Author-Supplied Keyword: cockroach; Author-Supplied Keyword: German cockroach; Author-Supplied Keyword: reference; Author-Supplied Keyword: relative potency; Author-Supplied Keyword: total protein content; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 0p; Illustrations: 4 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1046/j.1365-2222.2002.01397.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hirschfeld, Steven
AU - Pazdur, Richard
T1 - Oncology drug development: United States Food and Drug Administration perspective
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
Y1 - 2002/05//
VL - 42
IS - 2
M3 - Article
SP - 137
SN - 10408428
AB - The Food and Drug Administration (FDA) in the United States has multiple roles. The primary responsibilities for oncology drug products are the supervision of clinical research, the evaluation of marketing claims for new and previously approved drugs, the granting of exclusive marketing licenses for approved claims, and the monitoring of post-marketing activity for safety. Additional roles include providing incentives for developing products for rare diseases and children. The principles used for monitoring clinical studies are based on science, law and ethical guidelines. The principles used for evaluation of evidence to support marketing claims are based in science, law, regulation, and frequently the advice of a panel of external experts. Approved products should demonstrate patient benefit that is commensurate with the probable risks. The types of endpoints and their advantages and disadvantages for regulatory review are discussed. There are regulatory options available for conditional approval based on surrogate endpoints that are likely to predict patient benefit, a mechanism for reducing the time to review an application for indications with no known effective therapy, and procedures for providing access to patients for unapproved drugs. [Copyright &y& Elsevier]
AB - Copyright of Critical Reviews in Oncology/Hematology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOLOGY
KW - UNITED States
KW - Drug approval
KW - Drug development
KW - FDA
KW - Regulatory agency
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 7802055; Hirschfeld, Steven; Email Address: hirschfelds@cder.fda.gov Pazdur, Richard 1; Affiliation: 1: Division of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, 1451 Rockville Pike, HFD-150 Rockville, MD 20852, USA; Source Info: May2002, Vol. 42 Issue 2, p137; Subject Term: ONCOLOGY; Subject Term: UNITED States; Author-Supplied Keyword: Drug approval; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Regulatory agency; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahmad, Syed R.
AU - Kortepeter, Cindy
AU - Brinker, Allen
AU - Min Chen
AU - Beitz, Julie
T1 - Renal Failure Associated with the Use of Celecoxib and Rofecoxib.
JO - Drug Safety
JF - Drug Safety
Y1 - 2002/05//
VL - 25
IS - 7
M3 - Article
SP - 537
EP - 544
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Objective: Celecoxib and rofecoxib are two relatively new nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively inhibit the cyclo-oxygenase-2 (COX-2) isoenzyme at therapeutic concentrations. The nephrotoxic potential of selective COX-2 inhibitors has not been clearly established. This study was conducted in order to understand the association between acute renal failure and the two COX-2 inhibitors celecoxib and rofecoxib. Methods: A search was performed in the US Food and Drug Administration's (FDA) Adverse Event Reporting System (AERS) to identify cases of renal failure submitted to the FDA. A MEDLINE search of the English language literature was also performed to identify published cases of renal failure associated with celecoxib and rofecoxib. Results: One hundred twenty-two and 142 domestic US cases of celecoxib and rofecoxib-associated renal failure, respectively, were identified in the AERS database. The literature search identified 19 cases of acute renal impairment in association with celecoxib and rofecoxib. In addition, drug regulatory authorities in the UK, Canada, and Australia have received about 50 reports of renal failure with celecoxib and rofecoxib. Descriptive statistics of the AERS cases have been summarised in this report. Conclusions: Data from AERS and published case reports suggest that use of both these drugs is associated with renal effects similar to that of conventional nonselective NSAIDs. Physicians should be aware that serious or life-threatening renal failure has been reported in patients with normal or impaired renal function after short-term therapy with celecoxib and rofecoxib. Patients at greatest risk for renal injury are those with pre-existing renal impairment, heart failure, liver dysfunction, those taking diuretics and/or ACE inhibitors, and the elderly. Kidney function should be monitored closely for any signs of potential renal injuries soon after initiating treatment with these agents, especially in high-risk populations. In addition, healthcare practitioners should adequately warn patients of the signs and symptoms of serious renal toxicity, and of the need for them to see their physician promptly if they occur. Celecoxib and rofecoxib are not recommended for use in patients with advanced renal disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONSTEROIDAL anti-inflammatory agents
KW - CELECOXIB
KW - CYCLOOXYGENASE 2 -- Inhibitors
KW - KIDNEY diseases
KW - DRUGS -- Side effects
N1 - Accession Number: 16597547; Ahmad, Syed R. 1 Kortepeter, Cindy 1 Brinker, Allen 1 Min Chen 1 Beitz, Julie 1; Affiliation: 1: Division of Drug Risk Evaluation, Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: May2002, Vol. 25 Issue 7, p537; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: CELECOXIB; Subject Term: CYCLOOXYGENASE 2 -- Inhibitors; Subject Term: KIDNEY diseases; Subject Term: DRUGS -- Side effects; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Finkelman, Robert B.
AU - Orem, William
AU - Castranova, Vincent
AU - Tatu, Calin A.
AU - Belkin, Harvey E.
AU - Zheng, Baoshan
AU - Lerch, Harry E.
AU - Maharaj, Susan V.
AU - Bates, Anne L.
T1 - Health impacts of coal and coal use: possible solutions
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2002/05//
VL - 50
IS - 1-4
M3 - Article
SP - 425
SN - 01665162
AB - Coal will be a dominant energy source in both developed and developing countries for at least the first half of the 21st century. Environmental problems associated with coal, before mining, during mining, in storage, during combustion, and postcombustion waste products are well known and are being addressed by ongoing research. The connection between potential environmental problems with human health is a fairly new field and requires the cooperation of both the geoscience and medical disciplines. Three research programs that illustrate this collaboration are described and used to present a range of human health problems that are potentially caused by coal. Domestic combustion of coal in China has, in some cases, severely affected human health. Both on a local and regional scale, human health has been adversely affected by coals containing arsenic, fluorine, selenium, and possibly, mercury. Balkan endemic nephropathy (BEN), an irreversible kidney disease of unknown origin, has been related to the proximity of Pliocene lignite deposits. The working hypothesis is that groundwater is leaching toxic organic compounds as it passes through the lignites and that these organics are then ingested by the local population contributing to this health problem. Human disease associated with coal mining mainly results from inhalation of particulate matter during the mining process. The disease is Coal Worker''s Pneumoconiosis characterized by coal dust-induced lesions in the gas exchange regions of the lung; the coal worker''s “black lung disease”. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining -- Environmental aspects
KW - COAL miners
KW - DISEASES
KW - Arsenism
KW - Balkan endemic nephropathy
KW - Black lung disease
KW - Fluorosis
N1 - Accession Number: 7890374; Finkelman, Robert B. 1; Email Address: rbf@usgs.gov Orem, William 1 Castranova, Vincent 2 Tatu, Calin A. 3 Belkin, Harvey E. 1 Zheng, Baoshan 4 Lerch, Harry E. 1 Maharaj, Susan V. 5 Bates, Anne L. 1; Affiliation: 1: U.S. Geological Survey, Mail Stop 956, Reston, VA 20192, USA 2: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 3: Clinical Laboratory No. 1, County Hospital Timisoara, Str. L. Rebreanu 156, RO-1900 Timisoara, Romania 2 Institute of Public Health, Arad, Romania 4: Institute of Geochemistry, Guiyang, Guizhou Province, 550002, PR China 5: Armed Forces Institute of Pathology, Washington, DC 20306, USA; Source Info: May2002, Vol. 50 Issue 1-4, p425; Subject Term: COAL mines & mining -- Environmental aspects; Subject Term: COAL miners; Subject Term: DISEASES; Author-Supplied Keyword: Arsenism; Author-Supplied Keyword: Balkan endemic nephropathy; Author-Supplied Keyword: Black lung disease; Author-Supplied Keyword: Fluorosis; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crawford, Lester
AU - Crawford, Lester M Jr
T1 - From the Food and Drug Administration.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2002/05//5/1/2002
VL - 287
IS - 17
M3 - journal article
SP - 2203
EP - 2203
SN - 00987484
AB - Reports several news briefs related to the United States Food and Drug Administration (FDA). Conduction of a workshop by the FDA and the Plasma Protein Therapeutics Association entitled 'Comparability Studies for Human Plasma-Derived Therapeutics'; Approval of SIR-Spheres by the FDA for the treatment of unresectable metastatic liver tumors; Creation of a new television series for physicians and other health care professionals, called 'FDA Patient Safety News'; Others.
KW - LIVER tumors
KW - TELEVISION programs
KW - TREATMENT
KW - UNITED States. Food & Drug Administration
KW - PLASMA Protein Therapeutics Association (Organization)
N1 - Accession Number: 6589433; Crawford, Lester Crawford, Lester M Jr 1; Affiliation: 1: US Food and Drug Administration, USA; Source Info: 5/1/2002, Vol. 287 Issue 17, p2203; Subject Term: LIVER tumors; Subject Term: TELEVISION programs; Subject Term: TREATMENT; Company/Entity: UNITED States. Food & Drug Administration Company/Entity: PLASMA Protein Therapeutics Association (Organization); NAICS/Industry Codes: 512110 Motion Picture and Video Production; Number of Pages: 1p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, J.Z.
AU - Dong, R.G.
AU - Rakheja, S.
AU - Schopper, A.W.
T1 - Simulation of mechanical responses of fingertip to dynamic loading
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
Y1 - 2002/05//
VL - 24
IS - 4
M3 - Article
SP - 253
SN - 13504533
AB - Extended exposure to mechanical vibration has been related to many vascular, sensorineural and musculoskeletal disorders of the hand–arm system, frequently termed ‘hand–arm vibration syndrome’ (HAVS). A two-dimensional, nonlinear finite element model of a fingertip is developed to study the stress and strain fields of the soft tissue under dynamic loading, that may be encountered while grasping and operating a hand-held power tool. The model incorporates the most essential anatomical elements of a fingertip, such as soft tissue, bone, and nail. The finger is assumed to be in contact with a steel plate, simulating the interaction between the fingertip and a vibrating machine tool or handle. The soft tissue is assumed to be nonlinearly visco-elastic, while the nail, bone, and steel plate are considered to be linearly elastic. In order to study the time-dependent deformation behavior of the fingertip, the numerical simulations were performed under ramp-like loading with different ramping periods and sinusoidal vibrations of the contacting plate at three different frequencies (1, 10, and 31.5 Hz). Owing to relatively large deformations of the soft tissue under specified static and dynamic loading, Lagrangian large deformation theory was applied in the present analysis. The effects of the loading rate and the frequency of the sinusoidal vibration on the time-dependent strain/stress distributions in the different depth within the soft tissue of the fingertip are investigated numerically. Our simulations suggest that the soft tissue of the fingertip experiences high local stress and strain under dynamic loading and the fingertip may separate from the vibrating contact surface due to the viscous deformation behaviour of the soft tissue. For a given deformation, the high frequency loading produces a higher stress in the tissues compared to that obtained at a low frequency loading. The present model may serve as a useful tool to study the mechanism of tissue degeneration under vibratory loading encountered during operation of hand-held power tools. [Copyright &y& Elsevier]
AB - Copyright of Medical Engineering & Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMECHANICS
KW - ARM
KW - FINITE element method
KW - Finite element analysis
KW - Hyperelastic
KW - Soft tissue mechanics
KW - Vibration
KW - Visco-elastic
N1 - Accession Number: 7799583; Wu, J.Z.; Email Address: jwu@cdc.gov Dong, R.G. 1 Rakheja, S. 1 Schopper, A.W. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA; Source Info: May2002, Vol. 24 Issue 4, p253; Subject Term: BIOMECHANICS; Subject Term: ARM; Subject Term: FINITE element method; Author-Supplied Keyword: Finite element analysis; Author-Supplied Keyword: Hyperelastic; Author-Supplied Keyword: Soft tissue mechanics; Author-Supplied Keyword: Vibration; Author-Supplied Keyword: Visco-elastic; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beezhold, Donald H.
AU - Kostyal, David A.
AU - Tomazic-Jezic, Vesna J.
T1 - Measurement of latex proteins and assessment of latex protein exposure
JO - Methods
JF - Methods
Y1 - 2002/05//
VL - 27
IS - 1
M3 - Article
SP - 46
SN - 10462023
AB - Reduction of protein levels in manufactured natural rubber latex products is important for preventing sensitization and adverse allergic reactions to latex. Because of the complex nature of latex extracts, accurate protein measurement is a challenge. Standard total protein assays were effective in reducing protein levels from what were once extremely high levels, but these assays are plagued with false-positive reactions and limited sensitivity. An ELISA for antigenic protein has been standardized and promises to provide more consistent measurement of the proteins with potential to cause adverse reactions. Antigenic proteins represent the total protein fraction with potential to be allergenic. Measuring antigenic protein in a consistent manner should help to further reduce the level of sensitizing protein and further reduce allergic reactions to latex-medical products. [Copyright &y& Elsevier]
AB - Copyright of Methods is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RUBBER goods
KW - ALLERGY
KW - ANTIGENS
KW - Allergens
KW - Antigens
KW - Enzyme-linked immunosorbent assay
KW - Latex allergy
KW - Latex proteins
KW - Lowry protein assay
N1 - Accession Number: 7923555; Beezhold, Donald H. 1,2; Email Address: dbeezhol@inet.guthrie.org Kostyal, David A. 1 Tomazic-Jezic, Vesna J. 2; Affiliation: 1: Guthrie Research Institute, 1 Guthrie Square, Sayre, PA 18840, USA 2: FDA Center for Devices and Radiological Health, Rockville, MD, USA; Source Info: May2002, Vol. 27 Issue 1, p46; Subject Term: RUBBER goods; Subject Term: ALLERGY; Subject Term: ANTIGENS; Author-Supplied Keyword: Allergens; Author-Supplied Keyword: Antigens; Author-Supplied Keyword: Enzyme-linked immunosorbent assay; Author-Supplied Keyword: Latex allergy; Author-Supplied Keyword: Latex proteins; Author-Supplied Keyword: Lowry protein assay; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jean Meade, B.
AU - Woolhiser, Michael
T1 - Murine models for natural rubber latex allergy assessment
JO - Methods
JF - Methods
Y1 - 2002/05//
VL - 27
IS - 1
M3 - Article
SP - 63
SN - 10462023
AB - Murine models provide a powerful tool in the investigation of latex allergy and the development of intervention strategies. The immune responses to protein allergens of mice and humans are similar but differences related to the roles of IgE and IgG must be recognized. Mice have been shown to mount a dose and time-dependent IgE response to latex proteins following topical, respiratory, and subcutaneous exposures. Methods are available to evaluate cutaneous and respiratory responses to latex challenge in sensitized animals. These models have been used to investigate the role of route of exposure on the development of latex allergy and to provide a means for investigating the contribution of individual proteins to adverse respiratory and dermal responses. These models provide a mechanism for the evaluation of new technologies aimed at reducing the allergenicity of latex products, and for testing for the potential for cross-reactivity to new allergens in previously sensitized individuals. Murine models may also provide a method for testing immunotherapy strategies prior to initiating human trials. [Copyright &y& Elsevier]
AB - Copyright of Methods is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL models in research
KW - LATEX
KW - ALLERGY
KW - Active cutaneous anaphlyxis
KW - Allergy
KW - Animal models
KW - Enzyme-linked immunosorbent assay
KW - IgE
KW - Latex proteins
KW - Mouse
KW - Plethysmography
N1 - Accession Number: 7923560; Jean Meade, B. 1; Email Address: bhm8@cdc.gov Woolhiser, Michael 2; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: The Dow Chemical Company, Midland, MI, USA; Source Info: May2002, Vol. 27 Issue 1, p63; Subject Term: ANIMAL models in research; Subject Term: LATEX; Subject Term: ALLERGY; Author-Supplied Keyword: Active cutaneous anaphlyxis; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Animal models; Author-Supplied Keyword: Enzyme-linked immunosorbent assay; Author-Supplied Keyword: IgE; Author-Supplied Keyword: Latex proteins; Author-Supplied Keyword: Mouse; Author-Supplied Keyword: Plethysmography; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Farnham, John J.
AU - Tomazic-Jezic, Vesna J.
AU - Stratmeyer, Mel E.
T1 - Regulatory initiatives for natural latex allergy: US perspectives
JO - Methods
JF - Methods
Y1 - 2002/05//
VL - 27
IS - 1
M3 - Article
SP - 87
SN - 10462023
AB - The US Food and Drug Administration (FDA) has regulatory authority over foods, human drugs, cosmetics, medical devices, radiological products, biologics, and veterinary products. Among these products, FDA believes that the use of medical devices, including medical gloves, condoms, catheters, and breathing bags, represents the greatest source of natural latex proteins to exposed individuals. A medical device is defined in the Federal Food Drug and Cosmetic Act (FFDCA) as an instrument, apparatus, implement, machine, etc., that is intended for use in the diagnosis or treatment of disease or is intended to affect the structure or any function of the body of a human or other animal, and that does not achieve any of its principal intended purposes through chemical action in the body. This article provides some brief, general background about FDA''s medical device regulatory process and then addresses the issue of natural latex allergy. Finally we discuss the steps the Agency has taken to evaluate the magnitude and nature of the problem, and FDA''s efforts to assist manufacturers, health professionals, and others in minimizing exposure and sensitization to natural latex proteins in medical devices. [Copyright &y& Elsevier]
AB - Copyright of Methods is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - ALLERGY
KW - MEDICAL equipment
KW - Allergy
KW - Medical devices
KW - Natural latex
KW - Natural rubber
KW - Regulation
N1 - Accession Number: 7923563; Farnham, John J. 1; Email Address: jjf@cdrh.fda.gov Tomazic-Jezic, Vesna J. 2 Stratmeyer, Mel E. 2; Affiliation: 1: Office of Compliance, Center for Devices and Radiological Health, US Food and Drug Administration, 2094 Gaither Road, Rockville, MA 20850, USA 2: Office of Science and Technology, Center for Devices and Radiological Health, US Food and Drug Administration, 2094 Gaither Road, Rockville, MD 20850, USA; Source Info: May2002, Vol. 27 Issue 1, p87; Subject Term: LATEX; Subject Term: ALLERGY; Subject Term: MEDICAL equipment; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Medical devices; Author-Supplied Keyword: Natural latex; Author-Supplied Keyword: Natural rubber; Author-Supplied Keyword: Regulation; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawn, Stephen D.
AU - Butera, Salvatore T.
AU - Shinnick, Thomas M.
T1 - Tuberculosis unleashed: the impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2002/05//
VL - 4
IS - 6
M3 - Article
SP - 635
SN - 12864579
AB - The granuloma plays a critical role in the host immune response to Mycobacterium tuberculosis, containing the organism and confining it in a latent state in most infected individuals. Indeed, approximately one-third of the world’s population has latent M. tuberculosis infection. However, over the past decade, the human immunodeficiency virus type 1 (HIV-1) pandemic has profoundly affected the incidence and clinicopathological features of tuberculosis. This review examines the immunological mechanisms whereby HIV-1 impairs the establishment, maintenance and function of the tuberculous granuloma. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRANULOMA
KW - TUBERCULOSIS
KW - HIV (Viruses)
KW - Cell-mediated immunity
KW - Granuloma
KW - Human immunodeficiency virus type 1
KW - Mycobacterium tuberculosis
KW - Tuberculosis
N1 - Accession Number: 7819401; Lawn, Stephen D. 1; Email Address: stevelawn@yahoo.co.uk Butera, Salvatore T. 2 Shinnick, Thomas M. 1; Affiliation: 1: Tuberculosis/Mycobacteriology Branch, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Atlanta, GA 30333, USA 2: HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, 1600 Clifton Road NE, Atlanta, GA 30333, USA; Source Info: May2002, Vol. 4 Issue 6, p635; Subject Term: GRANULOMA; Subject Term: TUBERCULOSIS; Subject Term: HIV (Viruses); Author-Supplied Keyword: Cell-mediated immunity; Author-Supplied Keyword: Granuloma; Author-Supplied Keyword: Human immunodeficiency virus type 1; Author-Supplied Keyword: Mycobacterium tuberculosis; Author-Supplied Keyword: Tuberculosis; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flynn, Katherine M.
AU - Newbold, Retha R.
AU - Ferguson, Sherry A.
T1 - Multigenerational Exposure to Dietary Nonylphenol has No Severe Effects on Spatial Learning in Female Rats
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2002/05//
VL - 23
IS - 1
M3 - Article
SP - 87
SN - 0161813X
AB - Nonylphenol is a common intermediate in the production of many consumer compounds and reportedly acts as an estrogen mimic. Because estrogen affects the spatial learning and memory in rats, the effects of nonylphenol exposure on the performance of female rats in the Morris water maze were investigated. Here, Sprague–Dawley rats (F0) consumed soy-free diets containing 0, 25, 200 or 750 ppm nonylphenol (≈0, 2, 16 or 60 mg/kg per day) beginning on postnatal day (PND) 42 and continuing for two generations (F1 and F2) with breeding occurring within treatments. Females to be behaviorally tested (n=7 –8 per treatment per generation) were ovariectomized at adulthood and assessed for spatial learning and memory between PND 125–150 (young adult age). Each rat was tested for four consecutive days (three trials per day) in the Morris water maze with the platform in a fixed location. One week later, each subject was primed with estrogen and progesterone and assessed on a single day (three trials). The F1 rats continued on the same diets until PND 380–395 (middle aged) when they were re-tested as above (four consecutive days followed 1 week later with hormonal priming and a single test day). Latency to find the platform, path length and swim speed were averaged over the three trials per day and analyzed using repeated measures analyses of variance. There were no consistent effects of dietary nonylphenol exposure and no interactions of nonylphenol exposure on any measure of performance in either generation at the young age nor at the middle age in the F1 generation. When tested at the young adult age, however, hormone priming resulted in latencies and path lengths that were significantly shorter than in those exhibited during the unprimed test days, and there was no such effect when tested at middle age. Middle aged rats exhibited better performance than the same animals tested at a young age, likely as a result of familiarity and practice with the test paradigm. These data suggest that multigenerational dietary nonylphenol exposure does not cause gross alterations in Morris water maze performance in young adult or middle aged ovariectomized female rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONYLPHENOL
KW - SPACE perception
KW - RATS -- Physiology
KW - Age-related
KW - Endocrine disrupter
KW - Estrogen
KW - Memory
KW - Nonylphenol
KW - Water maze
N1 - Accession Number: 7824696; Flynn, Katherine M. 1 Newbold, Retha R. 2 Ferguson, Sherry A. 1; Email Address: sferguson@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Environmental Toxicology Program, Laboratory of Toxicology, National Institute of Environmental Health Sciences Research, Triangle Park, NC 27709, USA; Source Info: May2002, Vol. 23 Issue 1, p87; Subject Term: NONYLPHENOL; Subject Term: SPACE perception; Subject Term: RATS -- Physiology; Author-Supplied Keyword: Age-related; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: Estrogen; Author-Supplied Keyword: Memory; Author-Supplied Keyword: Nonylphenol; Author-Supplied Keyword: Water maze; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Hyung Sik
AU - Shin, Jae-Ho
AU - Moon, Hyun Ju
AU - Kang, Il Hyun
AU - Kim, Tae Sung
AU - Kim, In Young
AU - Seok, Ji-Hyun
AU - Pyo, Myoung-Yun
AU - Han, Soon Young
T1 - Comparative estrogenic effects of p-nonylphenol by 3-day uterotrophic assay and female pubertal onset assay
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2002/05//
VL - 16
IS - 3
M3 - Article
SP - 259
SN - 08906238
AB - Nonylphenol (NP) is widely used as a component of detergents, paints, pesticides, and many other formulated products. Several studies have demonstrated that NP is estrogenic in fish, avian, and mammalian cells. NP also competitively inhibits the binding of 17β-estradiol (E2) to the estrogen receptor (ER). However, there are relatively few in vivo data related to this issue in mammals. The aim of this study was to investigate the estrogenic activity of NP in animal models. We performed a 3-day uterotrophic assay using immature female rats for comparison with other endpoints of Tier I screening including vaginal opening (VO) in prepubertal intact female rats. For the uterotrophic assay, diethylstilbestrol (DES) (0.2 and 1.0 μg/kg) and p-NP (10, 25, 50, 100, and 200 mg/kg) were administered subcutaneously to immature Sprague–Dawley female rats for 3 consecutive days (postnatal days (PND) 20, 21, and 22). For the female pubertal onset assay, DES (0.2, 1.0, and 5.0 μg/kg) and p-NP (10, 50, and 100 mg/kg) were administered daily by oral gavage from 21 days of age for 20 days. In the uterotrophic assay, statistically significant increases in uterine wet weight were observed at doses of 100 and 200 mg/kg p-NP. DES (0.2 and 1.0 μg/kg) also significantly increased uterine weight compared to the vehicle control. In the female pubertal onset assay, the age of VO was advanced following oral exposure to DES (1.0 and 5.0 μg/kg) and p-NP (50 and 100 mg/kg). Estrous cyclicity was monitored in prepubertal rats from the day of VO to the day of necropsy. Irregular estrous cycles were observed in the groups treated with DES (5.0 μg/kg) and p-NP (50 and 100 mg/kg). High-dose DES (5.0 μg/kg) produced a persistent estrus state, whereas p-NP (50 and 100 mg/kg) increased the number of days in diestrus. Serum thyroxine (T4) concentrations were decreased in a dose-dependent manner by DES and p-NP treatment. A significant decrease in serum T4 level was observed at high-dose DES (5.0 μg/kg) and p-NP (100 mg/kg). Serum TSH level was significantly increased by DES (5.0 μg/kg) treatment. Statistically significant decreases in ovarian weight were observed in female rats treated with DES (5.0 μg/kg) and p-NP (100 mg/kg). Our data demonstrate that p-NP can accelerate the onset of puberty and alter estrous cyclicity in prepubertal female rats at oral doses lower than the subcutaneous doses typically used in the uterotrophic assay. We therefore suggest that the female pubertal onset assay may be used as a sensitive testing method to detect environmental agents with weak estrogenic activity, but requires further research. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONYLPHENOL
KW - ESTROGEN receptors
KW - Diethylstilbestrol
KW - Estrous cyclicity
KW - Female pubertal onset assay
KW - p-Nonylphenol
KW - Uterotrophic assay
KW - Vaginal opening
N1 - Accession Number: 7846180; Kim, Hyung Sik 1 Shin, Jae-Ho 1 Moon, Hyun Ju 1 Kang, Il Hyun 1 Kim, Tae Sung 1 Kim, In Young 1 Seok, Ji-Hyun 1 Pyo, Myoung-Yun 2 Han, Soon Young 1; Email Address: soonyoungh@kfda.go.kr; Affiliation: 1: Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, South Korea 2: College of Pharmacy, Sookmyung Women’s University, Chungpa-dong-2ka, Yongsan-ku, Seoul, South Korea; Source Info: May2002, Vol. 16 Issue 3, p259; Subject Term: NONYLPHENOL; Subject Term: ESTROGEN receptors; Author-Supplied Keyword: Diethylstilbestrol; Author-Supplied Keyword: Estrous cyclicity; Author-Supplied Keyword: Female pubertal onset assay; Author-Supplied Keyword: p-Nonylphenol; Author-Supplied Keyword: Uterotrophic assay; Author-Supplied Keyword: Vaginal opening; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chu, Chia-Chium
AU - Wu, Yuh-Shen
AU - Fu, Peter Pi-Cheng
T1 - Emission characters of particulate concentrations and dry deposition studies for incense burning at a Taiwanese temple.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2002/05//
VL - 18
IS - 4
M3 - Article
SP - 183
EP - 190
PB - Sage Publications, Ltd.
SN - 07482337
AB - Suspended particulate concentrations were measured at the Tzu Yun Yen temple in the Taichung region of Taiwan. The temple performs traditional incense burning. A universal sampler and a micro-orifice uniform deposited impactor (MOUDI) sampler with a dry deposition plate were used to measure the particulate concentrations. The results show that the average PM[sub 2.5]/PM[sub 10] ratio was 74% during the incense burning period at this temple. In addition, the average suspended particulate (PM[sub 10]) element concentration of anthropogenic element Zn (495 ng/m[sup 3]) was higher than the other anthropogenic elements (Pb, Mn, Ni, and Cd). Furthermore, the average mass size distribution was bimodal with major peaks occurring at 0.32-0.56 μm and 5.6-10 μm during the incense burning period. The dry deposition velocities of Cd used fine particulates (PM[sub 2.5]) and suspended particulate (PM[sub 10]) mode were 1.86 and 0.99 cm/s in this study, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INCENSE
KW - TEMPLES
KW - ZINC
KW - LEAD
KW - NICKEL
KW - CADMIUM
KW - DRY DEPOSITION VELOCITIES
KW - METAL ELEMENT
KW - PARTICULATE MATTER
KW - SIZE DISTRIBUTION
KW - TEMPLE
N1 - Accession Number: 10832578; Fang, Guor-Cheng 1 Chu, Chia-Chium 2 Wu, Yuh-Shen 1 Fu, Peter Pi-Cheng 3; Affiliation: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan 2: The chief of Intensive Care Unit, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; Source Info: 2002, Vol. 18 Issue 4, p183; Subject Term: INCENSE; Subject Term: TEMPLES; Subject Term: ZINC; Subject Term: LEAD; Subject Term: NICKEL; Subject Term: CADMIUM; Author-Supplied Keyword: DRY DEPOSITION VELOCITIES; Author-Supplied Keyword: METAL ELEMENT; Author-Supplied Keyword: PARTICULATE MATTER; Author-Supplied Keyword: SIZE DISTRIBUTION; Author-Supplied Keyword: TEMPLE; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 813110 Religious Organizations; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 8p; Document Type: Article
L3 - 10.1191/0748233702th140oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brennan, Michael J.
AU - Delogu, Giovanni
T1 - The PE multigene family: a ‘molecular mantra’ for mycobacteria
JO - Trends in Microbiology
JF - Trends in Microbiology
Y1 - 2002/05//
VL - 10
IS - 5
M3 - Article
SP - 246
SN - 0966842X
AB - The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Trends in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIA
KW - ANTIGENS
KW - MYCOBACTERIUM tuberculosis
KW - BACTERIAL genetics
N1 - Accession Number: 7792493; Brennan, Michael J. 1; Email Address: Brennan@cber.fda.gov Delogu, Giovanni 2; Affiliation: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29 Room 502, 29 Lincoln Drive, Bethesda, MD 20892, USA. 2: Dept of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy.; Source Info: May2002, Vol. 10 Issue 5, p246; Subject Term: MYCOBACTERIA; Subject Term: ANTIGENS; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: BACTERIAL genetics; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Homola, Jiřı
AU - Dostálek, Jakub
AU - Chen, Shengfu
AU - Rasooly, Avraham
AU - Jiang, Shaoyi
AU - Yee, Sinclair S.
T1 - Spectral surface plasmon resonance biosensor for detection of staphylococcal enterotoxin B in milk
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2002/05/05/
VL - 75
IS - 1/2
M3 - Article
SP - 61
SN - 01681605
AB - This work evaluates a newly developed wavelength modulation-based SPR biosensor for the detection of staphylococcal enterotoxin B (SEB) in milk. Two modes of operation of the SPR biosensor are described: direct detection of SEB and sandwich assay. In the sandwich assay detection mode, secondary antibodies are bound to the already captured toxin to amplify sensor response. Samples including SEB in buffer and SEB in milk were analyzed in this work. The SPR biosensor has been shown to be capable of directly detecting concentrations of SEB in buffer as low as 5 ng/ml. In sandwich detection mode, the lowest detection limit was determined to be 0.5 ng/ml for both buffer and milk samples. The reported wavelength modulation-based SPR sensor provides a generic platform which can be tailored for detection of various foodborne pathogens and agents for food analysis and testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAPHYLOCOCCAL diseases
KW - BIOSENSORS
KW - MILK -- Microbiology
KW - Biosensor
KW - Staphylococcal enterotoxin B
KW - Surface plasmon resonance
N1 - Accession Number: 7765677; Homola, Jiřı 1; Email Address: homola@ee.washington.edu Dostálek, Jakub 1 Chen, Shengfu 2 Rasooly, Avraham 3 Jiang, Shaoyi 2 Yee, Sinclair S. 1; Affiliation: 1: Department of Electrical Engineering, University of Washington, Box 352500 Seattle, WA, 98195, USA 2: Department of Chemical Engineering, University of Washington, Seattle, WA, 98195-1750, USA 3: US Food and Drug Administration, Division of Microbiological Studies, 200 C St. SW. HFS 515, Washington, DC, 20204, USA; Source Info: May2002, Vol. 75 Issue 1/2, p61; Subject Term: STAPHYLOCOCCAL diseases; Subject Term: BIOSENSORS; Subject Term: MILK -- Microbiology; Author-Supplied Keyword: Biosensor; Author-Supplied Keyword: Staphylococcal enterotoxin B; Author-Supplied Keyword: Surface plasmon resonance; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Cha, Chang-Jun
AU - Cerniglia, Carl E.
T1 - Purification and characterization of an erythromycin esterase from an erythromycin-resistant Pseudomonas sp.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002/05/07/
VL - 210
IS - 2
M3 - Article
SP - 239
SN - 03781097
AB - An erythromycin esterase (molecular mass 51 200 Da) was purified from Pseudomonas sp. GD100, which was isolated from a salmon hatchery sediment sample from Washington State. The pI of the protein was 4.5–4.8. The enzyme was inhibited by 1 mM mercuric acid, and had the substrate specificity for structurally related 14-membered macrolides, which decreased in the order of oleandomycin, erythromycin A and erythromycin A enol ether. The activity for erythromycin A varied with temperature, but the effect of pH was minimal at pH 6.0–9.0. The half-life of the enzyme was estimated to be 8.9 h at 35°C and 0.23 h at 55°C, and the activation energy of the catalytic reaction of erythromycin A was estimated at 16.2 kJ mol−1. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROMYCIN
KW - AQUACULTURE
KW - Aquaculture
KW - Erythromycin A
KW - Erythromycin A enol ether
KW - Mercuric chloride
KW - Oleandomycin
N1 - Accession Number: 7813997; Kim, Yong-Hak 1 Cha, Chang-Jun 1 Cerniglia, Carl E.; Email Address: ccerniglia@nctr.fda.gov]; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA; Source Info: May2002, Vol. 210 Issue 2, p239; Subject Term: ERYTHROMYCIN; Subject Term: AQUACULTURE; Author-Supplied Keyword: Aquaculture; Author-Supplied Keyword: Erythromycin A; Author-Supplied Keyword: Erythromycin A enol ether; Author-Supplied Keyword: Mercuric chloride; Author-Supplied Keyword: Oleandomycin; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mohan, Ketha V. Krishna
AU - Ghebrehiwet, Berhane
AU - Atreya, Chintamani D.
T1 - The N-terminal conserved domain of rubella virus capsid interacts with the C-terminal region of cellular p32 and overexpression of p32 enhances the viral infectivity
JO - Virus Research
JF - Virus Research
Y1 - 2002/05/10/
VL - 85
IS - 2
M3 - Article
SP - 151
SN - 01681702
AB - Cellular ‘defense collagens’ are produced to launch virus-specific responses to clear the invading viruses. Cellular p32, the C1q binding protein is one such protein. In this report, we identified the interaction of p32 derived from a human lung diploid cell line (WI-38) with rubella virus capsid (RVCP from Therien strain) N-terminal 28-amino acid domain, which is conserved among several RV strains including the vaccine strains. We further identified that the C-terminal 69 aa of the mature p32 is sufficient to interact with the CP. In addition, we observed that in three independent Vero 76-derived cell lines constitutively overexpressing p32, the RV infectivity was enhanced. Our results suggest that RV has evolved a strategy whereby one of its proteins is recruited to interact with, and exploit the cellular defense machinery to its advantage. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARRIER proteins
KW - CELL lines
KW - RUBELLA virus
KW - Immunofluorescence
KW - Infectivity
KW - Overexpression
KW - p32
KW - Rubella virus capsid
KW - Yeast two-hybrid
N1 - Accession Number: 7813963; Mohan, Ketha V. Krishna 1 Ghebrehiwet, Berhane 2,3 Atreya, Chintamani D. 1; Email Address: atreya@cber.fda.gov; Affiliation: 1: Laboratory of Pediatric and Respiratory Viral diseases, Division of Viral Products, Section of Viral Pathogenesis and Adverse Reactions, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29A, Room 2C-11, HFM-460, NIH Campus, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Department of Medicine, State University of New York, New York, NY 11794, USA 3: Department of Pathology, State University of New York, New York, NY 11794, USA; Source Info: May2002, Vol. 85 Issue 2, p151; Subject Term: CARRIER proteins; Subject Term: CELL lines; Subject Term: RUBELLA virus; Author-Supplied Keyword: Immunofluorescence; Author-Supplied Keyword: Infectivity; Author-Supplied Keyword: Overexpression; Author-Supplied Keyword: p32; Author-Supplied Keyword: Rubella virus capsid; Author-Supplied Keyword: Yeast two-hybrid; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rao, K. Murali Krishna
AU - Meighan, Terence
AU - Bowman, Linda
T1 - ROLE OF MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN THE PRODUCTION OF INFLAMMATORY MEDIATORS: DIFFERENCES BETWEEN PRIMARY RAT ALVEOLAR MACROPHAGES AND MACROPHAGE CELL LINES.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/05/21/
VL - 65
IS - 10
M3 - Article
SP - 757
EP - 768
SN - 15287394
AB - Stimulation of macrophages has been shown to activate all three families of mitogen activated protein kinases (MAPKs). However, variable results are reported in the literature with respect to the particular kinases activated with any given stimulus. In this study, the role of activation of MAPKs was examined in the production of inflammatory mediators by measuring the phosphorylation of the kinases and their ability to phosphorylate specific substrates in rat primary alveolar macrophages, a rat alveolar macrophage cell line (NR8383), and two mouse monocytic cell lines (RAW 264.7 and J774A.1). In the three cell lines examined, all three families of MAPKs were activated upon stimulation with either lipopolysaccharide (LPS) or LPS plus interferon-γ; in contrast, only ERK1/2 was activated in primary rat alveolar macrophages upon stimulation with LPS. Inhibition of ERK1/2 activation by the MEK inhibitor PD98059 abrogated nitric oxide and tumor necrosis factor-α (TNF-α) production in primary rat alveolar macrophages, but the p38 inhibitor SB203580 had no effect on the production of these two inflammatory mediators. These observations indicate that MAPK activation is cell specific and explain some of the conflicting results reported in the literature. These studies emphasize the need to exercise caution in extrapolating data from cell lines to primary cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLAMMATION -- Mediators
KW - ENZYME activation
KW - MITOGENS
N1 - Accession Number: 6677478; Rao, K. Murali Krishna 1 Meighan, Terence 1 Bowman, Linda 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2002, Vol. 65 Issue 10, p757; Subject Term: INFLAMMATION -- Mediators; Subject Term: ENZYME activation; Subject Term: MITOGENS; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/00984100290071027
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Kenney, Richard T.
AU - Regina Rabinovich, N.
AU - Pichyangkul, Sathit
AU - Price, Virginia L.
AU - Engers, Howard D.
T1 - 2nd meeting on novel adjuvants currently in/close to human clinical testing: World Health Organization—Organization Mondiale de la Sante´ Fondation Me´rieux, Annecy, France, 5–7 June 2000
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/22/
VL - 20
IS - 17/18
M3 - Proceeding
SP - 2155
SN - 0264410X
KW - Human clinical trials
KW - Novel adjuvants
KW - Preclinical testing
KW - Review
KW - Vaccine
N1 - Accession Number: 7803576; Kenney, Richard T. 1 Regina Rabinovich, N. 2 Pichyangkul, Sathit 3 Price, Virginia L. 4 Engers, Howard D. 4; Email Address: engersh@who.ch; Affiliation: 1: US Food and Drug Administration/CBER, Bethesda, MD, USA 2: Malaria Vaccine Initiative/PATH, Rockville, MD, USA 3: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 4: UNDP/World Bank, WHO Special Programme of Research and Training in Tropical Diseases, Avenue Appia 20, CH-1211, Geneva 27, Switzerland; Source Info: May2002, Vol. 20 Issue 17/18, p2155; Author-Supplied Keyword: Human clinical trials; Author-Supplied Keyword: Novel adjuvants; Author-Supplied Keyword: Preclinical testing; Author-Supplied Keyword: Review; Author-Supplied Keyword: Vaccine; Number of Pages: 9p; Document Type: Proceeding
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DB - aph
ER -
TY - JOUR
AU - Barbour, E.K.
AU - Abdelnour, A.
AU - Jirjis, F.
AU - Faroon, O.
AU - Farran, M.T.
T1 - Evaluation of 12 stabilizers in a developed attenuated Salmonella Enteritidis vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/22/
VL - 20
IS - 17/18
M3 - Article
SP - 2249
SN - 0264410X
AB - The development of a stable live attenuated Salmonella Enteritidis (SE) vaccine, resisting heat stress during transportation and storage in unequipped tropical and subtropical zones of the world, is highly recommended. Twelve stabilizers were individually supplemented into a 9 ml volume of sterile distilled water resulting in concentrations of 1, 2, 3, 4 and 5%. A volume of 1 ml of attenuated live SE vaccine is added over the 9 ml of each concentration of the stabilizers. The differently stabilized SE vaccines were stressed at 55 °C for 48 h. The lowest percent reductions in SE cell viability by specified level of each stabilizer in ascending order were: 22.3% by 2% skim milk, 55.1% by 5% bovine serum albumin (BSA), 59.2% by 4% sorbitol, 74.4% by 3% maltose, 75% by 2% honey, 91.3% by 3% histidine, 96.9% by 1% heparin, 97.5% by 4% dextrose, 97.9% by 5% lactose, 99.4% by 5% sucrose, 99.5% by 2% gelatin, and 100% by 1–5% glycerol. In narrowing the concentration levels of skim milk to include 1.00, 1.25, 1.50, 1.75, 2.00, 2.25, 2.50, 2.75, and 3.00%, the 2.50% was the optimum level resulting in minimal percent reduction in SE cell viability of 18.9% after exposure to the defined heat stress. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - BACTERIAL vaccines
KW - Live vaccine
KW - Salmonella Enteritidis
KW - Stabilizers
N1 - Accession Number: 7803589; Barbour, E.K. 1; Email Address: eb01@aub.edu.lb Abdelnour, A. 2 Jirjis, F. 3 Faroon, O. 4 Farran, M.T. 1; Affiliation: 1: Department of Animal Science, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon 2: Department of Animal Science, Faculty of Agricultural Sciences, The Holy Spirit University, Kaslik, Lebanon 3: Intervet Inc., Millsboro, DE, USA 4: United States Public Health Service, Centers for Disease Control, Atlanta, GA, USA; Source Info: May2002, Vol. 20 Issue 17/18, p2249; Subject Term: SALMONELLA enteritidis; Subject Term: BACTERIAL vaccines; Author-Supplied Keyword: Live vaccine; Author-Supplied Keyword: Salmonella Enteritidis; Author-Supplied Keyword: Stabilizers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McKinzie, Page B.
AU - Parsons, Barbara L.
T1 - Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2002/05/27/
VL - 517
IS - 1/2
M3 - Article
SP - 209
SN - 13835718
AB - Allele-specific competitive blocker PCR (ACB-PCR) is a sensitive allele-specific amplification method in which preferential amplification of the mutant allele occurs by using a primer that has more mismatches to the wild-type allele than to the mutant allele (mutant-specific primer, MSP). Additionally, a non-extendable primer with more mismatches to the mutant allele than to the wild-type allele (blocker primer, BP) competes with the MSP for binding to the wild-type allele, thereby reducing background amplification from the wild-type allele. ACB-PCR primer design is largely dependent upon the basepair substitution being measured, making it unclear if this method is broadly applicable. In an earlier study, an H-ras codon 61 CAA→AAA mutation had been detected by ACB-PCR at a sensitivity of 10−5. In this study, ACB-PCR was applied to two human K-ras codon 12 mutations: GGT→GTT and GGT→GAT . The method was optimized by systematically altering the concentrations of Perfect Match PCR Enhancer, MSP, BP, and dNTPs. For each mutation, mutant fractions as low as 10−5 were detected, indicating that this assay can be used on a variety of base substitution mutations. In addition, the results suggest that the 3′-terminal mismatches between the MSP and wild-type allele may be used to predict the ACB-PCR conditions that will be appropriate for the detection of other base substitution mutations. The range of concentrations for each of these components is narrow, making this method relatively easy to apply to additional mutational targets. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - MUTATION (Biology)
KW - ALLELES
KW - ACB-PCR
KW - Allele-specific amplification
KW - Basepair substitution
KW - K-ras
KW - Mutation detection
N1 - Accession Number: 7814704; McKinzie, Page B.; Email Address: pmckinzie@nctr.fda.gov Parsons, Barbara L. 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, HFT-120, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA; Source Info: May2002, Vol. 517 Issue 1/2, p209; Subject Term: POLYMERASE chain reaction; Subject Term: MUTATION (Biology); Subject Term: ALLELES; Author-Supplied Keyword: ACB-PCR; Author-Supplied Keyword: Allele-specific amplification; Author-Supplied Keyword: Basepair substitution; Author-Supplied Keyword: K-ras; Author-Supplied Keyword: Mutation detection; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baylor, Norman W.
AU - Egan, William
AU - Richman, Paul
T1 - Aluminum salts in vaccines—US perspective
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/31/5/31/2002 Supplement
VL - 20
M3 - Article
SP - S18
SN - 0264410X
AB - Aluminum in the form of aluminum hydroxide, aluminum phosphate or alum has been commonly used as an adjuvant in many vaccines licensed by the US Food and Drug Administration. Chapter 21 of the US Code of Federal Regulations [610.15(a)] limits the amount of aluminum in biological products, including vaccines, to 0.85 mg/dose. The amount of aluminum in vaccines currently licensed in the US ranges from 0.85–0.125 mg/dose. Clinical studies have demonstrated that aluminum enhances the antigenicity of some vaccines such as diphtheria and tetanus toxoids. Moreover, aluminum-adsorbed diphtheria and tetanus toxoids are distinctly more effective than plain fluid toxoids for primary immunization of children. There is little difference between plain and adsorbed toxoids for booster immunization. Aluminum adjuvants have a demonstrated safety profile of over six decades; however, these adjuvants have been associated with severe local reactions such as erythema, subcutaneous nodules and contact hypersensitivity. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALUMINUM -- Physiological effect
KW - VACCINES
KW - Adjuvants
KW - Aluminum
KW - Clinical trials
KW - Vaccines
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 7820532; Baylor, Norman W.; Email Address: baylor@cber.fda.gov Egan, William 1 Richman, Paul 1; Affiliation: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, MD, USA; Source Info: 5/31/2002 Supplement, Vol. 20, pS18; Subject Term: ALUMINUM -- Physiological effect; Subject Term: VACCINES; Author-Supplied Keyword: Adjuvants; Author-Supplied Keyword: Aluminum; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Vaccines; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 0p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wheeler, John S.
AU - Chou, Selene
T1 - Considerations and procedures in the derivation of ATSDR minimal risk levels
JO - Vaccine
JF - Vaccine
Y1 - 2002/05/31/5/31/2002 Supplement
VL - 20
M3 - Article
SP - S51
SN - 0264410X
AB - Minimal risk levels (MRLs) are health-based guidance values derived for individual substances by conducting a thorough review of the literature, identifying appropriate target organs of response, and identifying a dose level where a no adverse effect or the lowest adverse effect level is seen. This level is then evaluated for uncertainty in the data base and for other extenuating factors and subsequently adjusted with uncertainty or modifying factors. The resulting calculation yields the MRL that is defined as an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse noncancer health effects over a specified duration of exposure. Typically, MRLs are derived for different durations of exposure (acute, intermediate, chronic) and for different routes of exposure (oral, inhalation). The MRLs serve as useful reference values in evaluating human health from exposure to substances found at hazardous waste sites. Because of numerous requests of various programs, recent work has focused on expanding the applicability of MRLs to other situations and routes of exposure (dermal, food supply, intramuscular) beyond the traditional oral and inhalation exposure routes at waste sites. Results of work, in conjunction with the Agency for Toxic Substances and Disease Registry’s computational toxicology laboratory, shows that the use of computational methods, such as physiologically based pharmacokinetic modeling, may allow the MRL process to be adapted to unique durations and routes of exposure such as intramuscular injections. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REFERENCE values (Medicine)
KW - UNCERTAINTY
KW - Minimal risk level
KW - Reference dose
KW - Uncertainty factor
N1 - Accession Number: 7820538; Wheeler, John S.; Email Address: jzw1@cdc.gov Chou, Selene 1; Affiliation: 1: US Department of Health and Human Services Public Health Services, Agency for Toxic Substances and Disease Registry, Division of Toxicology, Atlanta, GA, USA; Source Info: 5/31/2002 Supplement, Vol. 20, pS51; Subject Term: REFERENCE values (Medicine); Subject Term: UNCERTAINTY; Author-Supplied Keyword: Minimal risk level; Author-Supplied Keyword: Reference dose; Author-Supplied Keyword: Uncertainty factor; Number of Pages: 0p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolf, R. Cameron
AU - Bond, K. C.
T1 - Exploring similarity between peer educators and their contacts and AIDS-protective behaviours in reproductive health programmes for adolescents and young adults in Ghana.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002/06//
VL - 14
IS - 3
M3 - Article
SP - 361
EP - 373
PB - Routledge
SN - 09540121
AB - This analysis explores the similarity between peer educators and their contacts. To examine interpersonal communication in the context of peer education, this study tested a new approach using multiple semi-structured interviews and network analysis to collect data from 106 peer educators and 526 of their contacts. These evaluation activities were conducted at three sites in Ghana during April 1998, in peri-urban and rural locations, and in in-school and out-of-school targeted settings. It was found that in their peer counselling and peer promotion activities peer educators tend to reach people who are like themselves (53% within 2 years of age, 59% same sex, 70% same ethnicity, and 65% same school status) however, this trend is not uniform among all youth and varies by demographic characteristics and their cultural environment. By examining the social networks of peer educators, it is possible to gain a better understanding of the process of peer education counselling in the context in which it occurs. The study also shows that controlling for other factors, contacts of peer educators who are highly similar regarding age, sex, ethnicity, and school status, are 1.74 times more likely (95% CI: 1.18, 2.56) to have done something to protect themselves from AIDS in the past three months. The results have relevance for programme managers and planners, researchers, and international agencies serving youth. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REPRODUCTIVE health
KW - AIDS (Disease)
KW - PUBLIC health personnel
KW - ATTITUDE (Psychology)
KW - GHANA
N1 - Accession Number: 6755016; Wolf, R. Cameron 1 Bond, K. C. 2; Affiliation: 1: Health Resources and Services Administration, Rockville, Maryland, USA 2: Assistant Professor, Department of International Health and Development, Tulane University School of Hygiene and Tropical Medicine, Ghana; Source Info: Jun2002, Vol. 14 Issue 3, p361; Subject Term: REPRODUCTIVE health; Subject Term: AIDS (Disease); Subject Term: PUBLIC health personnel; Subject Term: ATTITUDE (Psychology); Subject Term: GHANA; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/09540120220123748
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Farinas, Evelyn
AU - Swartz, Lynette
T1 - Comparison of reported and expected deaths in sildenafil (Viagra) users
JO - American Journal of Cardiology
JF - American Journal of Cardiology
Y1 - 2002/06//
VL - 89
IS - 11
M3 - Article
SP - 1331
SN - 00029149
N1 - Accession Number: 7809464; Wysowski, Diane K. 1; Email Address: wysowski@cder.fda.gov Farinas, Evelyn 2 Swartz, Lynette 1; Affiliation: 1: Office of Drug Safety , USA 2: Office of Drug Evaluation III, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jun2002, Vol. 89 Issue 11, p1331; Number of Pages: 4p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Birch, M. Eileen
T1 - Occupational Monitoring of Particulate Diesel Exhaust by NIOSH Method 5040.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 400
EP - 405
SN - 1047322X
AB - NMAM 5040 is a particulate carbon method based on a thermal-optical analysis technique. The method was evaluated and published as a method for monitoring occupational exposures to particulate diesel exhaust, but it is applicable to particulate carbon aerosols in general, and has been routinely used in both occupational and environmental settings. Both organic and elemental carbon are determined, but EC is a more selective measure of workplace diesel exposure. In previous studies, good agreement between TC results obtained by different methods has been achieved, but the OC-EC results for different methods have been quite variable. Although a reference material is not currently available to test the accuracy of different methods, previous studies indicate that purely thermal methods are subject to positive bias from organic materials that char. Charring and inadequate removal of refractory OC components during the nonoxidative mode (typically 550°C in nitrogen) likely explain the positive bias of thermal methods, as well as the large variability across methods. These interferences may be negligible in some cases (e.g., samples from mines), but they present significant biases in others (e.g., urban air samples, samples containing wood or cigarette smokes). Good intefiaboratory agreement was obtained in a round robin comparison between six laboratories that used NMAM 5040, which was not the case with purely thermal methods. Good agreement has also been seen in smaller-scale comparisons conducted for quality assurance purposes. Until a suitable reference material becomes available, such comparisons are recommended as part of a laboratory's QA procedures. At present, five commercial laboratories (4 in the United States and 1 in Canada) perform the 5040 analysis, and over 40 instruments are in use globally for environmental and occupational monitoring. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIESEL motor exhaust gas
KW - AIR pollution
KW - INDUSTRIAL hygiene
KW - HEALTH
N1 - Accession Number: 6632312; Birch, M. Eileen 1; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Mailstop R-7, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA.; Source Info: Jun2002, Vol. 17 Issue 6, p400; Subject Term: DIESEL motor exhaust gas; Subject Term: AIR pollution; Subject Term: INDUSTRIAL hygiene; Subject Term: HEALTH; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/10473220290035390
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ER -
TY - JOUR
AU - Daniels, William
AU - Miller, Aubrey
T1 - I-BEAM—An Innovative Building Air Quality Software Tool.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 406
EP - 408
SN - 1047322X
AB - Features the Indoor Air Quality Building Education and Assessment Model, a software for managing indoor air quality problems in buildings. Key features and specifications; Availability information; Key industrial applications.
KW - AIR quality management -- Software
KW - INDUSTRIAL hygiene
N1 - Accession Number: 6632311; Daniels, William 1 Miller, Aubrey; Affiliation: 1: U.S. Public Health Service Region VIII, 1961 Stout Street, Denver, CO 80294-3538; Source Info: Jun2002, Vol. 17 Issue 6, p406; Subject Term: AIR quality management -- Software; Subject Term: INDUSTRIAL hygiene; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10473220290035408
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ER -
TY - JOUR
AU - Gao, Pengfei
AU - Martin, Jennifer
T1 - Volatile Metabolites Produced by Three Strains of Stachybotrys chartarum Cultivated on Rice and Gypsum Board.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2002/06//
VL - 17
IS - 6
M3 - Article
SP - 430
EP - 436
SN - 1047322X
AB - Stachybotrys chartarum (atra) is a toxigenic fungus frequently found in water-damaged buildings. Although microbial volatile organic compounds (MVOCs) produced by Aspergillus, Penicillium, and other fungi have been investigated extensively, little information exists on what MVOCs can be produced by S. chartarum. In this study, three strains of S. chartarum isolated from water-damaged residential homes in Cleveland, Ohio, were cultivated on rice and gypsum board. Air samples were collected after one, two, three, four, and six weeks of cultivation using Tenax TA tubes. Unique MVOCs were determined and other alcohols, ketones, and terpenes were also investigated using gas chromatography/mass spectrometry after thermal desorption from the sampling tube. Four unique MVOCs, 1-butanol, 3-methyl-1-butanol, 3-methyl-2-butanol, and thujopsene, were detected on rice cultures, and only one of them (1-butanol) was detected on gypsum board cultures. For a given strain, volatiles were considerably different with different cultivation media. Concentration profiles of the volatile compounds varied among compounds; however,each compound exhibited corresponding concentration trends between the strains. In comparison with our previous studies of five Aspergillus species on gypsum board under the same experimental conditions, fewer unique MVOCs were produced by S. chartarum, and they were quite different. It thus may be possible to use marker-unique MVOCs as a fingerprint to distinguish fungi in indoor environments once enough information becomes available. Our findings also indicate that volatiles produced by S. chartarum may represent a relatively small fraction of the total volatiles present in problem buildings where Aspergillus spp., Penicillium spp., and other fungi usually coexist. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - STACHYBOTRYS
KW - INDUSTRIAL hygiene
KW - Cultures
KW - Fungi
KW - Stachybotrys atra
KW - Stachybotrys chartarum
KW - UNIQUE MVOCS
KW - VOLATILE METABOLITES
KW - WATER-DAMAGED BUILDINGS
N1 - Accession Number: 6632306; Gao, Pengfei 1 Martin, Jennifer 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Source Info: Jun2002, Vol. 17 Issue 6, p430; Subject Term: METABOLITES; Subject Term: STACHYBOTRYS; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: Cultures; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Stachybotrys atra; Author-Supplied Keyword: Stachybotrys chartarum; Author-Supplied Keyword: UNIQUE MVOCS; Author-Supplied Keyword: VOLATILE METABOLITES; Author-Supplied Keyword: WATER-DAMAGED BUILDINGS; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/10473220290035462
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Chi-Jen
T1 - Quality Control of Polyvalent Pneumococcal Polysaccharide-Protein Conjugate Vaccine by Nephelometry
JO - Biologicals
JF - Biologicals
Y1 - 2002/06//
VL - 30
IS - 2
M3 - Article
SP - 97
SN - 10451056
AB - A nephelometric method was used for quantitative analysis of individual polysaccharides (PSs) in a polyvalent pneumococcal conjugate vaccine using CRM197 as carrier protein. Using this method, the individual types 4, 6B, 9V, 14, 18C, 19F and 23F PSs were found to range between 82·3 to 119% of the manufacturer''s indicated values.During conjugation using reductive amination, pneumococcal PS was first oxidized to introduce aldehyde groups. Higher or lower levels of antigen-antibody reaction were observed in periodate activated and then reduced PS of some serotypes compared to non-treated PS. Use of oxidized and reduced PS may provide an early indication of change in conjugation process. Furthermore, since the final monovalent and polyvalent conjugate vaccines gradually change during the storage period, the nephelometry provides an useful analytical method for stability study of these vaccines. Copyright 2002 The International Association for Biologicals. Published by Elsevier Science Ltd. All rights reserved. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDES
KW - PNEUMOCOCCAL vaccine
N1 - Accession Number: 8507816; Lee, Chi-Jen 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, U.S.A.; Source Info: Jun2002, Vol. 30 Issue 2, p97; Subject Term: POLYSACCHARIDES; Subject Term: PNEUMOCOCCAL vaccine; Number of Pages: 7p; Document Type: Article
L3 - 10.1006/biol.2001.0320
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ER -
TY - JOUR
AU - SAXENA, R. K
AU - WEISSMAN, D
AU - SAXENA, Q. B
AU - SIMPSON, J
AU - LEWIS, D. M
T1 - Kinetics of changes in lymphocyte sub-populations in mouse lungs after intrapulmonary infection with M. bovis (Bacillus Calmette-Guerin) and identity of cells responsible for IFNγ responses.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2002/06//
VL - 128
IS - 3
M3 - Article
SP - 405
EP - 410
PB - Wiley-Blackwell
SN - 00099104
AB - SUMMARY Gamma interferon (IFNγ) plays a key role in host defense against pulmonary mycobacterial infections. A variety of lymphocyte subsets may participate in producing pulmonary IFNγ responses, but their relative contributions after mycobacterial infection have not been clearly elucidated. To address this question, C57Bl/6 female mice were infected by intrapulmonary instillation of 2·5 × 104 BCG (Mycobacterium bovis Bacillus Calmette-Guerin). Lymphocyte populations in lung interstitium were examined at different time points after the infection. BCG load in lungs peaked between 4 and 6 weeks post-infection and declined to very low levels by the 12th week of infection. Recovery of lung interstitial lymphocytes doubled by 4–6 weeks after infection and declined thereafter. Flow cytometric analysis of the lung-derived lymphocytes revealed that about 5% of the these cells made IFNγ in control mice, and this baseline IFNγ production involved T (CD3+ NK1.1- ), NK (CD3- NK1.1+ ) and NKT (CD3+ NK1.1+ ) cells. As the BCG lung infection peaked, the total number of CD3+ T cells in the lungs increased threefold at 5–6 weeks post-infection. There was a marked increase (sixfold) in the number of T cells secreting IFNγ 5–6 weeks post-infection. Some increase was also noted in the NKT cells making IFNγ, but the numbers of NK cells making IFNγ in BCG-infected lungs remained unaltered. Our results suggest that whereas NK and NKT cells contribute to baseline IFNγ secretion in control lungs, expansion in the IFNγ-producing T-cell population was essentially responsible for the augmented response seen in lungs of BCG-infected mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - MYCOBACTERIAL diseases
KW - LYMPHOCYTES
KW - BCG infection
KW - host
KW - Interferon-gamma
KW - mice
KW - resistance models
KW - T cells
N1 - Accession Number: 6814290; SAXENA, R. K 1 WEISSMAN, D 2 SAXENA, Q. B 3 SIMPSON, J 2 LEWIS, D. M 3; Affiliation: 1: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 2: Analytical Services Branch, HELD, National Institute of Occupational Safety and Health, Center of Disease Control and Prevention, Morgantown, WV, USA 3: Indian Council of Medical Research, New Delhi, India and; Source Info: Jun2002, Vol. 128 Issue 3, p405; Subject Term: INTERFERONS; Subject Term: MYCOBACTERIAL diseases; Subject Term: LYMPHOCYTES; Author-Supplied Keyword: BCG infection; Author-Supplied Keyword: host; Author-Supplied Keyword: Interferon-gamma; Author-Supplied Keyword: mice; Author-Supplied Keyword: resistance models; Author-Supplied Keyword: T cells; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2249.2002.01839.x
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ER -
TY - JOUR
AU - Norton, Susan B.
AU - Cormier, Susan M.
AU - Smith, Marc
AU - Jones, R. Christian
AU - Schubauer-Berigan, Mary
T1 - PREDICTING LEVELS OF STRESS FROM BIOLOGICAL ASSESSMENT DATA: EMPIRICAL MODELS FROM THE EASTERN CORN BELT PLAINS, OHIO, USA.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2002/06//
VL - 21
IS - 6
M3 - Article
SP - 1168
EP - 1175
SN - 07307268
AB - Interest is increasing in using biological community data to provide information on the specific types of anthropogenic influences impacting streams. We built empirical models that predict the level of six different types of stress with fish and benthic macroinvertebrate data as explanatory variables. Significant models were found for six stressor factors: stream corridor structure; siltation; total suspended solids (TSS), biochemical oxygen demand (BOD), and iron (Fe); chemical oxygen demand (COD) and BOD; zinc (Zn) and lead (Pb); and nitrate and nitrite (NOx) and phosphorus (P). Model R² values were lowest for the siltation factor and highest for TSS, BOD, and Fe. Model R² values increased when spatial relationships were incorporated into the model. The models generally performed well when applied to a random subset of the data. Performance was more mixed when models were applied to data collected from a previous time period, perhaps because of a change in the spatial structure of these systems. These models may provide a useful indication of the levels of different stresses impacting stream reaches in the Eastern Corn Belt Plains ecoregion of Ohio, USA. More generally, the models provide additional evidence that biological communities can serve as useful indicators of the types of anthropogenic stress impacting aquatic systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTIC communities
KW - RIVERS
KW - CHEMICAL oxygen demand
KW - EFFECT of human beings on fishes
KW - WATER pollution
KW - Fish
KW - Macroinvertebrates
KW - Multivariate regression
KW - Spatial autocorrelation
KW - Streams
N1 - Accession Number: 22126073; Norton, Susan B. 1; Email Address: norton.susan@epa.gov Cormier, Susan M. 2 Smith, Marc 3 Jones, R. Christian 4 Schubauer-Berigan, Mary 5; Affiliation: 1: U.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460 2: U.S. Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, Ohio 45268 3: Ohio Environmental Protection Agency, Ecological Assessment Section, Groveport, Ohio 43125, USA 4: George Mason University, Department of Environmental Science and Policy, Fairfax, Virginia 22030, USA 5: National Institute for Occupational Safety and Health, Department of Health and Human Services, Cincinnati, Ohio 45213, USA; Source Info: Jun2002, Vol. 21 Issue 6, p1168; Subject Term: BIOTIC communities; Subject Term: RIVERS; Subject Term: CHEMICAL oxygen demand; Subject Term: EFFECT of human beings on fishes; Subject Term: WATER pollution; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Macroinvertebrates; Author-Supplied Keyword: Multivariate regression; Author-Supplied Keyword: Spatial autocorrelation; Author-Supplied Keyword: Streams; Number of Pages: 8p; Illustrations: 11 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Frasch, H. Frederick
AU - Landsittel, Douglas P.
T1 - Regarding the sources of data analyzed with quantitative structure–skin permeability relationship methods (commentary on ‘Investigation of the mechanism of flux across human skin in vitro by quantitative structure–permeability relationships’)
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
Y1 - 2002/06//
VL - 15
IS - 5
M3 - Editorial
SP - 399
SN - 09280987
AB - We investigated the sources of data used in recently published predictive models of skin permeability. It was found that skin permeability coefficients for 63 compounds are poorly documented. We hypothesized that these coefficients were calculated using the simple two variable, three parameter ‘Potts and Guy’ regression equation and hence were not derived from experimental measurements. We therefore examined the distribution of residuals of these reported coefficients compared with the Potts and Guy predictions. The residuals cannot be described by a normal distribution. A substantial (51%) number of residuals equaled 0.00. Further analysis demonstrated that 89% (56 out of 63) of the skin permeability coefficients can be explained as being calculated by the Potts and Guy equation using different documented octanol–water partition coefficients, and/or transcription errors. The results strongly suggest that these 63 skin permeability coefficients are calculated and not experimentally determined—a conclusion subsequently confirmed by one of the developers of the data set. Continued use of these data would lead to biased model selection, underestimation of experimental variability, and overestimation of model predictive ability. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Permeability
KW - DATA analysis
KW - PARTITION coefficient (Chemistry)
KW - Data analysis
KW - Human skin
KW - Quantitative structure–skin permeability relationship
KW - Skin absorption
KW - Skin flux mechanism
N1 - Accession Number: 7814294; Frasch, H. Frederick; Email Address: hbf9@cdc.gov Landsittel, Douglas P. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS L-3030, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Jun2002, Vol. 15 Issue 5, p399; Subject Term: SKIN -- Permeability; Subject Term: DATA analysis; Subject Term: PARTITION coefficient (Chemistry); Author-Supplied Keyword: Data analysis; Author-Supplied Keyword: Human skin; Author-Supplied Keyword: Quantitative structure–skin permeability relationship; Author-Supplied Keyword: Skin absorption; Author-Supplied Keyword: Skin flux mechanism; Number of Pages: 5p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Litton, Charles D.
T1 - The use of light scattering and ion chamber responses for the detection of fires in diesel contaminated atmospheres
JO - Fire Safety Journal
JF - Fire Safety Journal
Y1 - 2002/06//
VL - 37
IS - 4
M3 - Article
SP - 409
SN - 03797112
AB - Experiments were conducted to determine the optical scattering properties of diesel particulate matter (DPM) and various combustion aerosols from both flaming and smoldering combustion sources at discrete angles of 15° and 30° in the forward direction and at a light source wavelength of 635 nm using a simple light scattering module. In addition to the scattering data, simultaneous measurements were made of the total aerosol mass concentration; light extinction at an average wavelength of 546 nm; and the response of a common bipolar ion chamber typical of residential smoke detectors modified to allow the aerosols to flow through the chamber. The results of these experiments indicate, for DPM and combustion aerosols, the intensities per unit mass concentration depend not only upon whether the aerosol is DPM or combustion aerosol but also upon the type of combustion aerosol. The results also indicate that the ion chamber responses are greatest for DPM, followed by the response to flaming combustion aerosols (FCA) and lowest for smoldering combustion aerosols (SCA). For light scattering, the greatest intensities are found for SCA, followed by the intensities from FCA, and lowest for DPM. This report describes the experiments, their results, and the use of these results to develop design criteria for early warning fire sensors capable of the rapid and reliable detection of fires in atmospheres that may or may not be contaminated by the products produced from diesel engines. [Copyright &y& Elsevier]
AB - Copyright of Fire Safety Journal is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIGHT -- Scattering
KW - IONIZATION chambers
N1 - Accession Number: 8800069; Litton, Charles D. 1; Email Address: chl3@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Center, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Source Info: Jun2002, Vol. 37 Issue 4, p409; Subject Term: LIGHT -- Scattering; Subject Term: IONIZATION chambers; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 17p; Document Type: Article
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ER -
TY - JOUR
AU - Kover, Christine
AU - Jones, Cheryl
AU - Chunliu Zhan
AU - Gergen, Peter J.
AU - Basu, Jayasree
T1 - Nurse Staffing and Postsurgical Adverse Events: An Analysis of Administrative Data from a Sample of U.S. Hospitals,1990–1996.
JO - Health Services Research
JF - Health Services Research
Y1 - 2002/06//
VL - 37
IS - 3
M3 - Article
SP - 611
EP - 629
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To examine the impact of nurse staffing on selected adverse events hypothesized to be sensitive to nursing care between 1990 and 1996, after controlling for hospital characteristics. Data Sources/Study Setting. The yearly cross-sectional samples of hospital discharges for states participating in the National Inpatient Sample (NIS) from 1990–1996 were combined to form the analytic sample. Six states were included for 1990–1992, four states were added for the period 1993–1994, and three additional states were added in 1995–1996. Study Design. The study design was cross-sectional descriptive. Data Collection/Extraction Methods. Data for patients aged 18 years and older who were discharged between 1990 and 1996 were used to create hospital-level adverse event indicators. Hospital-level adverse event data were defined by quality indicators developed by the Health Care Utilization Project (HCUP). These data were matched to American Hospital Association (AHA) data on community hospital characteristics, including registered nurse (RN) and licensed practical/vocational nurse (LPN) staffing hours, to examine the relationship between nurse staffing and four postsurgical adverse events: venous thrombosis/pulmonary embolism, pulmonary compromise after surgery, urinary tract infection, and pneumonia. Multivariate modeling using Poisson regression techniques was used. Principal Findings. An inverse relationship was found between RN hours per adjusted inpatient day and pneumonia (p < .05) for routine and emergency patient admissions. Conclusions. The inverse relationship between pneumonia and nurse staffing are consistent with previous findings in the literature. The results provide additional evidence for health policy makers to consider when making decisions about required staffing levels to minimize adverse events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING services
KW - CRITICAL care medicine
KW - UNITED States
KW - adverse events
KW - outcomes
KW - Registered nurse
KW - staffing
N1 - Accession Number: 11650254; Kover, Christine 1 Jones, Cheryl 2 Chunliu Zhan 3 Gergen, Peter J. 4 Basu, Jayasree 4; Affiliation: 1: Division of Nursing, School of Education, New York University 2: School of Nursing, University of North Carolina 3: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality 4: Center for Primary Care Research, Agency for Healthcare Research and Quality; Source Info: Jun2002, Vol. 37 Issue 3, p611; Subject Term: NURSING services; Subject Term: CRITICAL care medicine; Subject Term: UNITED States; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: outcomes; Author-Supplied Keyword: Registered nurse; Author-Supplied Keyword: staffing; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn
T1 - AHRQ Update.
JO - Health Services Research
JF - Health Services Research
Y1 - 2002/06//
VL - 37
IS - 3
M3 - Article
SP - xiii
EP - xviii
PB - Wiley-Blackwell
SN - 00179124
AB - Provides information on congresses on health services and health policy as of June 2002. 2002 Annual Research Meeting of the Academy of Health Services and Health Policy in Washington, D.C.; Fourth Annual Child Health Services Research Meeting in Washington, D.C.; International Health Policy and Research Exchange: Lessons from Europe and Japan on Innovation in Health Insurance Schemes and Provision of Long-Term Care meeting in Washington, D.C.
KW - HEALTH services administration
KW - HEALTH planning
KW - CONFERENCES & conventions
N1 - Accession Number: 11650260; Clancy, Carolyn 1; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ); Source Info: Jun2002, Vol. 37 Issue 3, pxiii; Subject Term: HEALTH services administration; Subject Term: HEALTH planning; Subject Term: CONFERENCES & conventions; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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ER -
TY - JOUR
AU - Castro, Felipe González
AU - Alarcón, Eduardo Hernández
T1 - INTEGRATING CULTURAL VARIABLES INTO DRUG ABUSE PREVENTION AND TREATMENT WITH RACIAL/ETHNIC MINORITIES.
JO - Journal of Drug Issues
JF - Journal of Drug Issues
Y1 - 2002///Summer2002
VL - 32
IS - 3
M3 - Article
SP - 783
EP - 810
SN - 00220426
AB - A set of variables, identified as “cultural variables,” is introduced as important descriptors of the life experiences of people from the major ethnic/racial minority groups in the United States. It is stated that most contemporary models for prevention and treatment of substance abuse are “culturally blind” to the effects of these cultural variables on the risk of substance abuse among racial/ethnic minority people. Accordingly, a viable strategy for culturally relevant research and program design is to integrate these cultural variables into extant models to create culturally rich models for research as well as for the development of prevention and treatment programs. The use of “model programs” is discussed in regard to the competing aims of maintaining program fidelity while also making cultural adaptations to these model programs to make them more culturally relevant. Strategies and recommendations are presented for integrating cultural variables into prevention and treatment programs that purport to serve racial/ethnic minority people. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Drug Issues is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse -- Prevention
KW - DRUG abuse -- Treatment
KW - RACIAL minorities
KW - ETHNICITY
KW - CULTURE
KW - SUBSTANCE abuse -- Treatment
KW - RESEARCH
KW - UNITED States
N1 - Accession Number: 7511607; Castro, Felipe González 1 Alarcón, Eduardo Hernández 2; Affiliation: 1: Professor of Clinical Psychology, Department of Psychology, Arizona State University 2: Division of State and Community Systems Development, Center for Substance Abuse Prevention; Source Info: Summer2002, Vol. 32 Issue 3, p783; Subject Term: DRUG abuse -- Prevention; Subject Term: DRUG abuse -- Treatment; Subject Term: RACIAL minorities; Subject Term: ETHNICITY; Subject Term: CULTURE; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: RESEARCH; Subject Term: UNITED States; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 28p; Illustrations: 3 Diagrams, 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 8980
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ER -
TY - JOUR
AU - Murono, Eisuke P.
AU - Derk, Raymond C.
T1 - Exposure to octylphenol increases basal testosterone formation by cultured adult rat Leydig cells
JO - Journal of Steroid Biochemistry & Molecular Biology
JF - Journal of Steroid Biochemistry & Molecular Biology
Y1 - 2002/06//
VL - 81
IS - 2
M3 - Article
SP - 181
SN - 09600760
AB - 4-Tert-octylphenol (OP) is a breakdown product of 4-tert-octylphenol ethoxylate, which is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. OP has been reported to exhibit weak estrogenic activity in many assay systems. The studies described herein examined an unusual effect of OP in increasing constitutive testosterone levels of cultured Leydig cells from young adult rats. The increase in testosterone was both dose and time sensitive, and this response was observed in medium lacking both calcium and magnesium and containing a membrane-permeable calcium chelator, suggesting that the increase in testosterone was not mediated by an increase in the permeability of extracellular calcium into cells or the redistribution/release of calcium from intracellular stores, respectively. Cellular cAMP levels also were unaffected by OP alone in cultured Leydig cells. Furthermore, initial exposure to 2000 nM OP alone for 4 h did not alter the subsequent conversion of endogenous cholesterol or exogenously added 22 (R)hydroxycholesterol to testosterone, suggesting that the increase in testosterone was not due to the enhanced availability of endogenous cholesterol or an increase in cholesterol side-chain cleavage activity, respectively. The increase in testosterone also was observed in the presence of the pure estrogen antagonist, ICI 182,780, or a 5α-reductase inhibitor, suggesting that this effect of OP was not mediated through the estrogen receptor α or β pathway or by inhibition of Leydig cell testosterone metabolism, respectively. In addition, exposure of cells to comparable concentrations of two different detergents, Triton X-100 or sodium cholate, did not increase testosterone levels, suggesting that this effect of OP was not due to its potential detergent qualities. Although these studies did not identify specific mechanism(s) that increase constitutive testosterone levels by OP, they identify specific pathways that appear not to be involved. The physiological relevance of this observation is not known; nevertheless, they illustrate potential diverse actions of OP in modulating the level of androgen secreted by Leydig cells, and they emphasize that some actions of OP do not appear to be mediated through the estrogen receptor α or β pathway. [Copyright &y& Elsevier]
AB - Copyright of Journal of Steroid Biochemistry & Molecular Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TESTOSTERONE
KW - DETERGENTS
KW - Leydig cell
KW - Octylphenol
KW - Testosterone
N1 - Accession Number: 7849880; Murono, Eisuke P.; Email Address: eem8@cdc.gov Derk, Raymond C. 1; Affiliation: 1: Health Effects Laboratory Division, Pathology and Physiology Research Branch, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA; Source Info: Jun2002, Vol. 81 Issue 2, p181; Subject Term: TESTOSTERONE; Subject Term: DETERGENTS; Author-Supplied Keyword: Leydig cell; Author-Supplied Keyword: Octylphenol; Author-Supplied Keyword: Testosterone; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325611 Soap and Other Detergent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 9p; Document Type: Article
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ER -
TY - JOUR
AU - DE VEAU, I. F
AU - PEDERSOLI, W
AU - CULLISON, R
AU - BAKER, J
T1 - Pharmacokinetics of phenylbutazone in beef steers.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2002/06//
VL - 25
IS - 3
M3 - Article
SP - 195
EP - 200
PB - Wiley-Blackwell
SN - 01407783
AB - De Veau, I. F., Pedersoli, W., Cullison R., Baker J. Pharmacokinetics of phenylbutazone in beef steers. J. vet. Pharmacol. Therap. 25, 195–200. Phenylbutazone was administered intravenously to a group of 11 beef steers at a dosage of 6 mg/kg of body weight. Whole plasma and protein-free plasma were analyzed for phenylbutazone residues. Pharmacokinetic parameters of total and free phenylbutazone in plasma were calculated using a noncompartmental method. In regards to whole plasma data, the mean volume of distribution at steady state (V ss ), was 140 mL/kg body weight, with a mean (±SEM) terminal elimination half-life (t 1/2 ) of 34 ± 9 h. The mean clearance was 3.2 mL/h/kg body weight. The V ss , as determined from the protein-free plasma fraction, was 54093 mL/kg body weight. This larger V ss of free phenylbutazone compared with total plasma phenylbutazone was attributed to a high degree of plasma protein binding, as well as the greater penetration of free phenylbutazone into tissues. The mean t 1/2 of free phenylbutazone was 35 ± 12 h. This similarity to the t 1/2 estimated from total plasma phenylbutazone data is attributed to an equilibrium between free and plasma phenylbutazone during the terminal elimination phase. The pharmacokinetic parameters of free and total plasma phenylbutazone in beef steers are statistically similar to those previously reported for lactating dairy cows. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-inflammatory agents
KW - VETERINARY drugs
KW - PHARMACOKINETICS
KW - VETERINARY pharmacology
N1 - Accession Number: 6871934; DE VEAU, I. F 1,2 PEDERSOLI, W 3 CULLISON, R 3 BAKER, J 4; Affiliation: 1: U.S. Food and Drug Administration (USFDA), Center for Veterinary Medicine (CVM), Office of Research (OR)/Division of Residue Chemistry, 8401 Muirkirk Road, Laurel, MD 20708, 2: Current Address: United States Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD 20852, 3: USFDA/CVM/OR, Division of Animal Research, 8401 Muirkirk Road, Laurel, MD 20708, 4: USFDA/CVM/Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals, 7500 Standish Place, Metro Park North II, Rockville, MD 20855, USA; Source Info: Jun2002, Vol. 25 Issue 3, p195; Subject Term: ANTI-inflammatory agents; Subject Term: VETERINARY drugs; Subject Term: PHARMACOKINETICS; Subject Term: VETERINARY pharmacology; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2885.2002.00406.x
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ER -
TY - JOUR
AU - MARTINEZ, M
AU - LANGSTON, C
AU - MARTIN, T
AU - CONNER, D
T1 - Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2002/06//
VL - 25
IS - 3
M3 - Article
SP - 201
EP - 220
PB - Wiley-Blackwell
SN - 01407783
AB - Martinez M., Langston C., Martin T., Conner D. Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective. J. vet. Pharmacol. Therap. 25, 201–220. The Generic Animal Drug Patent Term Restoration Act (GADPTRA) enacted in 1988 provided the same benefits to animal drug products that were granted to human generic products. It has been over 13 years since the GADPTRA was enacted, and veterinary drug sponsors and regulators have gained enormous insight and experience into some of the unique challenges associated with the determination of product bioequivalence for veterinary dosage forms. Moreover, advances in information and technology have opened both new issues that must be addressed and new mechanisms for demonstrating product bioequivalence. While many aspects of the existing Center for Veterinary Medicine Bioequivalence Guidance continue to provide invaluable guidance to the animal drug industry, there are also aspects of this guidance that are being called into question. Therefore, during the 2001 annual meeting of the American Academy of Veterinary Pharmacology and Therapeutics, participants were asked to address issues and concerns associated with the evaluation of veterinary product bioequivalence. This manuscript provides a summary of the concerns and discussions that transpired. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY drugs
KW - VETERINARY pharmacology
N1 - Accession Number: 6871933; MARTINEZ, M 1 LANGSTON, C 2 MARTIN, T 3 CONNER, D 4; Affiliation: 1: Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD, USA, 2: Department of Clinical Sciences, College of Veterinary Medicine, MS, USA, 3: Department of Veterinary Biosciences, University of Illinois College of Veterinary Medicine, IL, USA, 4: Division of Bioequivalence, Center for Drug Research and Evaluation, Food and Drug Administration, Rockville, MD, USA; Source Info: Jun2002, Vol. 25 Issue 3, p201; Subject Term: VETERINARY drugs; Subject Term: VETERINARY pharmacology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 20p; Document Type: Article
L3 - 10.1046/j.1365-2885.2002.00407.x
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ER -
TY - JOUR
AU - Yu, Stella M.
AU - Park, Christina H.
AU - Schwalberg, Renee H.
T1 - Factors Associated with Smoking Cessation Among U.S. Pregnant Women.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2002/06//
VL - 6
IS - 2
M3 - Article
SP - 89
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Objectives : This study examines smoking and smoking cessation behaviors among U.S. pregnant women and seeks to identify the sociodemographic correlates of smoking cessation in pregnancy. Methods : The 1998 NHIS Pregnancy and Smoking supplement was analyzed, including 5288 U.S. women (weighted to represent 13,714,358 women) who gave birth to a live-born infant in the past 5 years. Four categories of smoking behavior were analyzed: nonsmoking at last pregnancy, persistent smoking throughout pregnancy, attempting unsuccessfully to quit during pregnancy, and successfully quitting during pregnancy. Logistic regression was used to isolate risk factors for each of the smoking behaviors and to examine factors associated with attempted and successful cessation. Results : The women most likely to attempt to quit smoking in pregnancy were Hispanic women (OR = 3.09) and women who have smoked for less than 10 years (OR = 2.75 for women aged 18–24.) In general, for the groups at highest risk of smoking at the start of pregnancy, the odds of being a persistent smoker were higher than the odds of being an unsuccessful quitter, which in turn were higher than the odds of quitting successfully. The factors associated with attempts to quit included Hispanic ethnicity, higher education, above-poverty income, and shorter duration of smoking, while the combined effect of age and smoking duration was the only one significantly associated with successful quitting. In every age group, longer smoking duration was associated with lower likelihood of attempting to quit as well as successful quitting. Conclusions : The factors most strongly associated with attempts to quit smoking were Hispanic ethnicity and the combined effect of age and smoking duration. Future smoking cessation and relapse prevention programs should be developed, taking into consideration the critical factors of age, ethnicity, income, geography, and addiction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING cessation
KW - PREGNANCY
KW - ETHNICITY
KW - HEALTH education
KW - MATERNAL age
KW - education
KW - ethnicity
KW - maternal age
KW - pregnancy
KW - smoking cessation
N1 - Accession Number: 11307896; Yu, Stella M. 1,2; Email Address: syu@hrsa.gov Park, Christina H. 3 Schwalberg, Renee H. 3; Affiliation: 1: Health Resources and Services Administration, Maternal and Child Health Bureau, Rockville, Maryland 2: Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, 18-41, Rockville, Maryland 20857z 3: Maternal and Child Health Information Resource Center, Washington, DC; Source Info: Jun2002, Vol. 6 Issue 2, p89; Subject Term: SMOKING cessation; Subject Term: PREGNANCY; Subject Term: ETHNICITY; Subject Term: HEALTH education; Subject Term: MATERNAL age; Author-Supplied Keyword: education; Author-Supplied Keyword: ethnicity; Author-Supplied Keyword: maternal age; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: smoking cessation; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 9p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Morris, Anne
AU - Bloom, Joan
T1 - Contextual Factors Affecting Job Satisfaction and Organizational Commitment in Community Mental Health Centers Undergoing System Changes in the Financing of Care.
JO - Mental Health Services Research
JF - Mental Health Services Research
Y1 - 2002/06//
VL - 4
IS - 2
M3 - Article
SP - 71
EP - 83
SN - 15223434
AB - This study examines the relationship between contextual factors and job satisfaction and organizational commitment among a sample of 148 administrators and staff in 17 community mental health centers undergoing the transition from fee-for-service (FFS) reimbursement to capitation of Medicaid-funded mental health services in Colorado. Hierarchical linear modeling was used to assess both organizational level factors as well as factors at the individual level of analysis in relation to job satisfaction and organizational commitment. Results indicated significant associations between type of financing for Medicaid-funded services and organizational commitment. Direct, nonprofit capitation was positively linked to organizational commitment, relative to traditional FFS reimbursement. Aggregate perceptions about the organization, including its culture and climate, and the formalization of policies and procedures were strongly linked to job attitudes, over and above individual perceptions about the organization. Individual perceptions of the organization were also related to job attitudes as was respondent level within the hierarchy of the organization. These findings are discussed in terms of their implications for research and intervention in mental health service settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Health Services Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOB satisfaction
KW - EMPLOYEES -- Attitudes
KW - WORK values
KW - MENTAL health services
KW - COLORADO
KW - capitation
KW - hierarchical linear modeling
KW - human service organizations
KW - job satisfaction
KW - mental health services
KW - organizational commitent
N1 - Accession Number: 50189283; Morris, Anne 1; Email Address: amorris@uclink4.berkeley.edu Bloom, Joan 1,2; Affiliation: 1: Center for Mental Health Services Research, University of California, Berkeley, California 2: School of Public Health, University of California, Berkeley, California; Source Info: Jun2002, Vol. 4 Issue 2, p71; Subject Term: JOB satisfaction; Subject Term: EMPLOYEES -- Attitudes; Subject Term: WORK values; Subject Term: MENTAL health services; Subject Term: COLORADO; Author-Supplied Keyword: capitation; Author-Supplied Keyword: hierarchical linear modeling; Author-Supplied Keyword: human service organizations; Author-Supplied Keyword: job satisfaction; Author-Supplied Keyword: mental health services; Author-Supplied Keyword: organizational commitent; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 13p; Document Type: Article
L3 - 10.1023/A:1015248116246
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ER -
TY - JOUR
AU - Plakas, Steven M.
AU - El Said, Kathleen R.
AU - Jester, Edward L.E.
AU - Ray Granade, H.
AU - Musser, Steven M.
AU - Dickey, Robert W.
T1 - Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures
JO - Toxicon
JF - Toxicon
Y1 - 2002/06//
VL - 40
IS - 6
M3 - Article
SP - 721
SN - 00410101
AB - Previously, we analyzed Eastern oysters (Crassostrea virginica) naturally exposed to a Karenia brevis red tide and found that brevetoxins (PbTx) are rapidly accumulated and metabolized. Several metabolites were isolated and later identified, including a cysteine-PbTx conjugate (MH+: m/z 1018) and its sulfoxide product (m/z 1034). In the present study, we confirm and extend those findings by examining PbTx metabolism and elimination in oysters exposed to pure toxins (PbTx-2 and -3) under controlled conditions. Waterborne PbTx-3 was rapidly accumulated, but not metabolized, in the oyster and was largely eliminated within 2 weeks after exposure. In contrast, PbTx-2 was accumulated and rapidly metabolized. Metabolites of PbTx-2 included the reduction product PbTx-3 (m/z 897), and the cysteine conjugates (m/z 1018 and 1034) isolated previously from the field samples. Levels of the metabolite PbTx-3 in PbTx-2-exposed oysters were highest immediately after exposure and declined at a rate similar to parent PbTx-3 in PbTx-3-exposed oysters. Cysteine-PbTx persisted for 8 weeks after exposure. The same metabolites were confirmed in oysters exposed to laboratory cultures of K. brevis. PbTx metabolites contribute to neurotoxic shellfish poisoning (NSP) and should be included in analytical protocols for monitoring shellfish toxicity after a K. brevis red tide event. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMERICAN oyster
KW - TOXINS
KW - POISONOUS shellfish
KW - Brevetoxin
KW - Brevetoxin metabolism
KW - Cytotoxicity
KW - Eastern oyster
KW - Karenia brevis
KW - Liquid chromatography/mass spectrometry
N1 - Accession Number: 7791767; Plakas, Steven M. 1; Email Address: splakas@cfsan.fda.gov El Said, Kathleen R. 1 Jester, Edward L.E. 1 Ray Granade, H. 1 Musser, Steven M. 2 Dickey, Robert W. 1; Affiliation: 1: Gulf Coast Seafood Laboratory, US Food and Drug Administration, 1 Iberville Drive, P.O. Box 158, Dauphin Island, AL 36528-0158, USA 2: Instrumentation and Biophysics Branch, US Food and Drug Administration, 200 C Street, Washington, DC 20204, USA; Source Info: Jun2002, Vol. 40 Issue 6, p721; Subject Term: AMERICAN oyster; Subject Term: TOXINS; Subject Term: POISONOUS shellfish; Author-Supplied Keyword: Brevetoxin; Author-Supplied Keyword: Brevetoxin metabolism; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: Eastern oyster; Author-Supplied Keyword: Karenia brevis; Author-Supplied Keyword: Liquid chromatography/mass spectrometry; Number of Pages: 9p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Walton, Marc K
T1 - Endpoint considerations for clinical trials.
JO - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
Y1 - 2002/06/02/Jun2002 Supplement
VL - 3
IS - 2
M3 - Article
SP - 3
EP - 6
PB - Taylor & Francis Ltd
SN - 14660822
AB - Discusses issues relating to the endpoint considerations for clinical trials. Focus on amyotrophic lateral sclerosis (ALS); Clinical development programs for a therapeutic agent; Difficulties with some of the more readily interpretable clinical efficacy endpoints; Description of an ideal efficacy endpoint.
KW - AMYOTROPHIC lateral sclerosis
KW - CLINICAL trials
KW - DRUG development
N1 - Accession Number: 7303613; Walton, Marc K 1; Affiliation: 1: Division of Clinical Trial Design and Analysis, Center for Biologics Evaluation and Research, FDA; Source Info: Jun2002 Supplement, Vol. 3 Issue 2, p3; Subject Term: AMYOTROPHIC lateral sclerosis; Subject Term: CLINICAL trials; Subject Term: DRUG development; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/146608202320374129
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DB - aph
ER -
TY - JOUR
AU - Kongphanich, Aurus
AU - Hieda, Michinari
AU - Kurokawa, Kenji
AU - Murata, Takashi
AU - Kobayashi, Nobuyuki
T1 - Overcoming the blockade at the upstream of caspase cascade in Fas-resistant HTLV-I-infected T cells by cycloheximide
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2002/06/14/
VL - 294
IS - 3
M3 - Article
SP - 714
SN - 0006291X
AB - In spite of carrying large amount of Fas death receptor on the cell surface, Human T cell lymphotropic virus type-I (HTLV-I)-infected T cell lines are resistant to Fas-mediated cytotoxicity. We investigated the mechanism(s) of HTLV-I-induced Fas resistancy. Western blotting and enzymatic activity analyses revealed that the Fas-elicited apoptotic signal in HTLV-I-infected T cells was intervened at the level(s) prior to the activation of caspase-8. Upon stimulation, the clustering of Fas receptors scarcely occurred in HTLV-I-infected cells. Cycloheximide treatment converted the resistant cells to sensitive cells; the presence of short-lived anti-apoptotic molecule(s) that can block the caspase-8 activation within HTLV-I-infected T cells is suggested. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HTLV (Viruses)
KW - CELL-mediated cytotoxicity
KW - Caspase-8
KW - Cycloheximide
KW - Fas clustering
KW - Fas/APO-1/CD95
KW - HTLV-I
KW - Resistance
N1 - Accession Number: 7925731; Kongphanich, Aurus 1,2 Hieda, Michinari 1 Kurokawa, Kenji 3 Murata, Takashi 1 Kobayashi, Nobuyuki 1; Email Address: nobnob@net.nagasaki-u.ac.jp; Affiliation: 1: Laboratory of Molecular Biology of Diseases, School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bnkyo-machi, Nagasaki 852-8521, Japan 2: Technical Division, Food and Drug Administration, Ministry of Public Health, Thailand 3: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; Source Info: Jun2002, Vol. 294 Issue 3, p714; Subject Term: HTLV (Viruses); Subject Term: CELL-mediated cytotoxicity; Author-Supplied Keyword: Caspase-8; Author-Supplied Keyword: Cycloheximide; Author-Supplied Keyword: Fas clustering; Author-Supplied Keyword: Fas/APO-1/CD95; Author-Supplied Keyword: HTLV-I; Author-Supplied Keyword: Resistance; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - An, Beum-Soo
AU - Kang, Sung Keun
AU - Shin, Jae-Ho
AU - Jeung, Eui-Bae
T1 - Stimulation of calbindin-D9k mRNA expression in the rat uterus by octyl-phenol, nonylphenol and bisphenol
JO - Molecular & Cellular Endocrinology
JF - Molecular & Cellular Endocrinology
Y1 - 2002/06/14/
VL - 191
IS - 2
M3 - Article
SP - 177
SN - 03037207
AB - Quantification of estrogen-induced changes in the expression levels of endogenous genes such as pS2 and vitellogenin could be an assay to detect estrogenicity of chemicals. Considering its regulation by estrogen, in the present study, we hypothesize that the calbindin-D9k (CaBP-9k) gene has the possibility as a biomarker for estrogenic response of the environmental estrogens. We analyzed the time- and dose-dependent CaBP-9k mRNA expression in the immature rats by 3-day injection of 17β-estradiol (E2) and alkylphenol acid [octyl-phenol (OP) and nonylphenol (NP)] and bisphenol A(BPA)) which are environmentally persistent and reported to have some estrogenic activity in experimental test systems. The expression of CaBP-9k mRNA was compared with uterotropic response of the compounds. A significant increase in CaBP-9k mRNA expression was observed when treated with 1000 mg/kg body weight (BW) per day of OP (18-fold versus control), NP (17-fold versus control) and BPA (6-fold versus control) for 3 days in dot blot assays. Using Northern blot analysis, a more dramatic increase of CaBP-9k mRNA expression was observed when treated with 1000 mg/kg BW per day of OP (132-fold versus control) and NP (113-fold versus control) for 3 days. Treatment with 10 and 100 mg/kg BW per day of NP and 100 mg/kg BW per day of OP for 3 days induced a small but significant increase in CaBP-9k mRNA expression. As expected, a single dose of E2 (40 μg/kg BW per day) for 3 days induced a significant increase in CaBP-9k mRNA expression as revealed by dot (15-fold versus control) or Northern blot assay (102-fold versus control). In a time response experiment using Northern blot assay, a significant increase in CaBP-9k mRNA expression was observed as early as 3 h, peaked at 6 h and continued until 72 h after treatment with 1000 mg/kg BW per day of OP, NP, and 48 h after treatment with 1000 mg/kg BW per day of BPA. A similar time-dependent response was observed when assessed by dot blot assay. Uterotropic response of the compounds was determined and compared with CaBP-9k mRNA expression. The alkylphenolic compounds induced a significant increase in the uterine wet weight at 1000 mg/kg BW per day of OP and NP, not BPA. A strong correlation between in vivo uterotropic assay and CaBP-9k mRNA expression assay was observed. In order to investigate the possible mechanisms by which the compounds regulate CaBP-9k mRNA expression, we studied the effect of the compound on the ERα mRNA level using total RNA from the treated rats. The alkylphenolic compounds as well as E2 stimulate the expression of ERα mRNA in a similar pattern to that of CaBP-9k mRNA in terms of dose- and time-dependent response. Strong regulation of CaBP-9k mRNA expression by E2 and the environmental estrogens and its correlation with in vivo uterotropic assay suggest that CaBP-9k gene can be used as a biomarker gene for assaying estrogenicity of putative estrogenic compounds. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Endocrinology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTROGEN
KW - PHENOL
KW - GENE expression
KW - Calbindin-D9k
KW - Eds
KW - Rat uterus
N1 - Accession Number: 7823024; An, Beum-Soo 1 Kang, Sung Keun 2 Shin, Jae-Ho 3 Jeung, Eui-Bae 1; Email Address: ebjeung@trut.chungbuk.ac.kr; Affiliation: 1: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of Korea 2: Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea 3: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Jun2002, Vol. 191 Issue 2, p177; Subject Term: ESTROGEN; Subject Term: PHENOL; Subject Term: GENE expression; Author-Supplied Keyword: Calbindin-D9k; Author-Supplied Keyword: Eds; Author-Supplied Keyword: Rat uterus; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Barger, Mark
AU - Robinson, Victor A.
AU - Leonard, Stephen S.
AU - Landsittel, Douglas
AU - Castranova, Vincent
T1 - Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat
JO - Toxicology
JF - Toxicology
Y1 - 2002/06/14/
VL - 175
IS - 1-3
M3 - Article
SP - 63
SN - 0300483X
AB - Most previous studies of silica toxicity have used relatively high exposure doses of silica. In this study, male rats received by intratracheal instillation either vehicle, aged or freshly fractured silica at a dose of either 5 μg/rat once a week for 12 weeks (total dose=60 μg) or 20 μg/rat once a week for 12 weeks (total dose=240 μg). One week after the last exposure, bronchoalveolar lavage (BAL) was conducted and markers of pulmonary inflammation, alveolar macrophage (AM) activation and pulmonary damage were examined. For rats exposed to a total of 60 μg silica, both aged and freshly fractured silica increased polymorphonuclear leukocytes (PMN) yield and AM activation above control to a similar degree, but no evidence of pulmonary damage, as measured by BAL fluid lactate dehydrogenase activity or albumin concentration, was detected. For rats exposed to 240 μg silica, aged or freshly fractured silica increased PMN yield and AM activation above control. However, zymosan-stimulated and l-NAME sensitive AM chemiluminescence was greater for rats exposed to freshly fractured silica compared to aged silica. Exposure to 240 μg aged or freshly fractured silica also resulted in pulmonary damage, but the extent of this damage did not differ between the two types of silica. The results suggest that exposure of rats to silica levels far lower than those previously examined can cause pulmonary inflammation. In addition, exposure to freshly fractured silica causes greater generation of reactive oxygen species from AM, measured as AM chemiluminescence, in comparison to aged silica, but there is an apparent threshold below which this difference does not occur. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - CHEMILUMINESCENCE
KW - Chemiluminescence
KW - Inflammation
KW - Silica
N1 - Accession Number: 7817315; Porter, Dale W.; Email Address: dporter@cdc.gov Barger, Mark 1 Robinson, Victor A. 1 Leonard, Stephen S. 1 Landsittel, Douglas 1 Castranova, Vincent 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505, USA; Source Info: Jun2002, Vol. 175 Issue 1-3, p63; Subject Term: SILICA; Subject Term: CHEMILUMINESCENCE; Author-Supplied Keyword: Chemiluminescence; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Silica; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zamorano, P.
AU - Taboga, O.
AU - Domınguez, M.
AU - Romera, A.
AU - Puntel, M.
AU - Tami, C.
AU - Mongini, C.
AU - Waldner, C.
AU - Palma, E.
AU - Sadir, A.
T1 - BHV-1 DNA vaccination: effect of the adjuvant RN-205 on the modulation of the immune response in mice
JO - Vaccine
JF - Vaccine
Y1 - 2002/06/21/
VL - 20
IS - 21/22
M3 - Article
SP - 2656
SN - 0264410X
AB - It is well documented that adjuvants improve the immune response generated by traditional viral vaccines, but less is known about the effects of adjuvants on the immune response elicited by DNA vaccines. In this study, we have investigated the use of RN-205 (immunomodulator containing a membrane rich in lipopolysaccharide from gram-negative bacteria) as an adjuvant and analyzed the humoral and cellular specific immune responses elicited by DNA vaccines based on the bovine herpesvirus-1 (BHV-1) glycoprotein D (gD). The comparison of the antibody response induced in mice by a mixture of the three different versions of DNA gD (membrane-anchored, secreted and cytosolic) formulated with or without RN-205 showed that the immunomodulator did not affect the total specific humoral response. The cellular immune response induced in mice immunized with vaccines plus RN-205 was higher than that obtained in mice vaccinated without RN-205, not only in the indexes of proliferation tests but in the number of IL-4 and γIFN secreting cells. When total spleen cells were marked with specific monoclonal antibodies against surface markers, a significant increase in the macrophage population of all the groups receiving RN-205 was observed. CD8 and CD4 positive cells were also increased but to a lesser extent. Our results indicate that the incorporation of RN-205 into DNA vaccines induces an increase of the cellular specific immune response in mice. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - DNA vaccines
KW - Adjuvant
KW - Glycoprotein D
KW - Immune response
N1 - Accession Number: 7811941; Zamorano, P. 1,2; Email Address: pzamorano@cicv.inta.gov.ar Taboga, O. 1 Domınguez, M. 1 Romera, A. 1 Puntel, M. 1 Tami, C. 1,3 Mongini, C. 4 Waldner, C. 4 Palma, E. 1,2 Sadir, A. 1,2; Affiliation: 1: Centro de Investigación en Ciencias Veterinarias y Agronómicas, INTA, CC25, (1712) Castelar, Serrano 669, Buenos Aires, Argentina 2: CONICET, Bethesda, MD 20852, USA 3: Center for Biological Evaluation and Research, Food and Drug Administration, Buenos Aires, Argentina 4: Centro de Estudios Farmacológicos y Botánicos (CEFYBO, CONICET), Rivaoavia 1917, Buenos Aires, Argentina; Source Info: Jun2002, Vol. 20 Issue 21/22, p2656; Subject Term: IMMUNE response; Subject Term: DNA vaccines; Author-Supplied Keyword: Adjuvant; Author-Supplied Keyword: Glycoprotein D; Author-Supplied Keyword: Immune response; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - McGarrity, Lynda J.
AU - Morris, Suzanne M.
AU - Heflich, Robert H.
T1 - Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2002/06/27/
VL - 518
IS - 1
M3 - Article
SP - 55
SN - 13835718
AB - A novel approach was developed for rapidly estimating the frequency of specific mutations in genetically engineered Chinese hamster ovary (CHO) cells. We designed double-transgenic CHO cell lines that contain a transgene consisting of the sequence coding for green fluorescent protein under the control of a tetracycline (Tet) responsive promoter and a second transgene coding for the constitutively expressed Tet repressor. Cultures of these CHO cells were treated with γ-radiation, N-methyl-N-nitrosourea or methyl methanesulfonate, and the fluorescence of individual cells from both control and treated cultures was measured by flow cytometry. The treatments increased the number of highly fluorescent cells, those with presumed mutations in the Tet-repressor gene. Mutant cells from γ-radiation-exposed cultures were isolated by fluorescence-activated cell sorting, cultured, and individual clones expanded. A PCR-based analysis indicated that the highly fluorescent expanded cells had lost the transgene coding for the Tet repressor, suggesting that the system mainly detects large genetic alterations. A similar approach may be useful for making high-throughput in vivo models for mutation detection. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - GREEN fluorescent protein
KW - TRANSGENIC mice
KW - CELL lines
KW - γ
KW - -Radiation
KW - Fluorescence activated cell sorting
KW - Green fluorescent protein (GFP)
KW - Tetracycline (Tet) repressor
N1 - Accession Number: 7824290; Dobrovolsky, Vasily N.; Email Address: vdobrovolsky@nctr.fda.gov McGarrity, Lynda J. 1 Morris, Suzanne M. 1 Heflich, Robert H. 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-120, 72079 Jefferson, AR, USA; Source Info: Jun2002, Vol. 518 Issue 1, p55; Subject Term: MUTATION (Biology); Subject Term: GREEN fluorescent protein; Subject Term: TRANSGENIC mice; Subject Term: CELL lines; Author-Supplied Keyword: γ; Author-Supplied Keyword: -Radiation; Author-Supplied Keyword: Fluorescence activated cell sorting; Author-Supplied Keyword: Green fluorescent protein (GFP); Author-Supplied Keyword: Tetracycline (Tet) repressor; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, X. D.
AU - Murray, D. K.
AU - Lewis, D. M.
AU - Siegel, P. D.
T1 - Dose-response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model.
JO - Allergy
JF - Allergy
Y1 - 2002/07//
VL - 57
IS - 7
M3 - Article
SP - 620
EP - 626
PB - Wiley-Blackwell
SN - 01054538
AB - Background: Trimellitic anhydride (TMA)-induced occupational asthma is thought to be associated with its ability to acylate proteins and to induce production of TMA-specific immunoglobulin (Ig)E. Though the respiratory tract is considered to be a major exposure route leading to airway sensitization, the potential role of dermal exposure producing asthmatic sensitization is not known. The present study examines the ability of dry TMA powder to sensitize Brown Norway rats when applied, topically, to the skin. Methods: A patch of hair was carefully clipped with scissors on the rat's back. Dry TMA powder (0.3, 1.25, 5 and 20 mg) was administered on days 0, 7, 14 and 21, and the area occluded with surgical tape overnight after each application. Residual powder recovered from the occluded skin was analyzed by proton nuclear magnetic resonance and was still predominantly TMA. Circulating anti-TMA IgE and IgG were measured by ELISA. Results: TMA elicited dose-dependent production of specific IgE and IgG. Specific antibodies were detectable 2 weeks after the first TMA exposure and peaked between 3 and 4 weeks. Conclusion: The data suggest that topical skin exposure to dry TMA powder can induce allergic/immunological sensitization as demonstrated by the production of specific antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - RESEARCH
KW - IMMUNOGLOBULIN G
KW - IMMUNOLOGY
KW - IMMUNE response
KW - IMMUNOSUPPRESSION
KW - Brown Norway rat
KW - Dermal exposure
KW - IgE
KW - occupational asthma
KW - sensitization
KW - skin
KW - Trimellitic anhydride
N1 - Accession Number: 6985452; Zhang, X. D. 1 Murray, D. K. 1 Lewis, D. M. 1 Siegel, P. D. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Jul2002, Vol. 57 Issue 7, p620; Subject Term: ALLERGY; Subject Term: RESEARCH; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNOLOGY; Subject Term: IMMUNE response; Subject Term: IMMUNOSUPPRESSION; Author-Supplied Keyword: Brown Norway rat; Author-Supplied Keyword: Dermal exposure; Author-Supplied Keyword: IgE; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: sensitization; Author-Supplied Keyword: skin; Author-Supplied Keyword: Trimellitic anhydride; Number of Pages: 7p; Document Type: Article
L3 - 10.1034/j.1398-9995.2002.03548.x
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kleinman, Dushanka V.
T1 - The guide to community preventive services: Oral health
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2002/07//
VL - 23
IS - 1
M3 - Editorial
SP - 1
SN - 07493797
N1 - Accession Number: 7832094; Kleinman, Dushanka V. 1; Email Address: dushanka.kleinman@nih.gov; Affiliation: 1: Office of the Chief Dental Officer, U.S. Public Health Service, Bethesda, Maryland, USA; Source Info: Jul2002, Vol. 23 Issue 1, p1; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Armstrong, Tina N.
AU - Reimschuessel, Renate
AU - Bradley, Brian P.
T1 - DNA damage, histologial changes and DNA repair in larval Japanese medaka (Oryzias latipes) exposed to ultraviolet-B radiation
JO - Aquatic Toxicology
JF - Aquatic Toxicology
Y1 - 2002/07//
VL - 58
IS - 1/2
M3 - Article
SP - 1
SN - 0166445X
AB - Cyclobutane dimer formation, photorepair capability and histological damage were compared among four differently pigmented strains of larval Japanese medaka (Oryzias latipes) to determine whether pigmentation modifies the level of UV-B radiation (290–320 nm) inducible damage in these fish. One-day post-hatch medaka were exposed to one of several UV-B fluence rates with or without photoreactivating light for 5 days for 7 h per day. Their DNA was extracted for analysis by ELISA for cyclobutane pyrimidine dimers or the larvae were processed for histological examination. At the higher UV-B fluence rates tested, wild-type melanophore-containing medaka formed significantly more dimers than at least one of the other strains tested. Wild-type medaka also showed significantly less photorepair capability than the white melanophore-lacking medaka. The wild-type larvae had significantly more necrosis than the orange–red melanophore-lacking larvae at the lower UV-B fluence rate tested and at the higher fluence rate used, the wild-type medaka also exhibited significantly more necrosis than the white melanophore-lacking larvae. Of the 19 medaka observed with cellular hyperplasia, six were wild-type. These six individual larvae showed the greatest degree of cellular hyperplasia. Cellular hyperplasia appeared to be greatest at the lowest UV-B fluence rate used. The presence of melanophores in the wild-type medaka may have contributed to an increased level of tissue damage in this strain when compared to the other strains. [Copyright &y& Elsevier]
AB - Copyright of Aquatic Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - LARVAE
KW - CYCLOBUTADIENE
KW - HYPERPLASIA
KW - JAPAN
KW - Cyclobutane pyrimidine dimer
KW - Fish
KW - Hyperplasia
KW - Necrosis
KW - Photoreactivation
KW - UV-B
N1 - Accession Number: 7792834; Armstrong, Tina N. 1; Email Address: ta@bbl-inc.com Reimschuessel, Renate 2; Email Address: rreimsch@cvm.fda.gov Bradley, Brian P. 3; Email Address: bbradley@umbc.edu; Affiliation: 1: BBL Sciences, 326 First Street, Suite 200, Annapolis, MD 21403-2678, USA 2: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA 3: Department of Biological Sciences, University of Maryland (UMBC), 1000 Hilltop Circle, Baltimore, MD 21250, USA; Source Info: Jul2002, Vol. 58 Issue 1/2, p1; Subject Term: DNA; Subject Term: LARVAE; Subject Term: CYCLOBUTADIENE; Subject Term: HYPERPLASIA; Subject Term: JAPAN; Author-Supplied Keyword: Cyclobutane pyrimidine dimer; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Hyperplasia; Author-Supplied Keyword: Necrosis; Author-Supplied Keyword: Photoreactivation; Author-Supplied Keyword: UV-B; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gubler, Duane J.
T1 - The Global Emergence/Resurgence of Arboviral Diseases As Public Health Problems
JO - Archives of Medical Research
JF - Archives of Medical Research
Y1 - 2002/07//
VL - 33
IS - 4
M3 - Article
SP - 330
SN - 01884409
AB - During the past 20 years there has been a dramatic resurgence or emergence of epidemic arboviral diseases affecting both humans and domestic animals. These epidemics have been caused primarily by viruses thought to be under control such as dengue, Japanese encephalitis, yellow fever, and Venezuelan equine encephalitis, or viruses that have expanded their geographic distribution such as West Nile and Rift Valley fever. Several of these viruses are presented as case studies to illustrate the changing epidemiology. The factors responsible for the dramatic resurgence of arboviral diseases in the waning years of the 20th century are discussed, as is the need for rebuilding the public health infrastructure to deal with epidemic vector-borne diseases in the 21st century. [Copyright &y& Elsevier]
AB - Copyright of Archives of Medical Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARBOVIRUSES
KW - EPIDEMIOLOGY
KW - Arbovirus
KW - Dengue
KW - Emerging infectious diseases
KW - Japanese encephalitis
KW - Rift Valley fever
KW - Venezuelan equine encephalitis
KW - West Nile
KW - Yellow fever
N1 - Accession Number: 7875593; Gubler, Duane J. 1; Email Address: dgubler@cdc.gov; Affiliation: 1: Department of Health and Human Services, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO, USA; Source Info: Jul2002, Vol. 33 Issue 4, p330; Subject Term: ARBOVIRUSES; Subject Term: EPIDEMIOLOGY; Author-Supplied Keyword: Arbovirus; Author-Supplied Keyword: Dengue; Author-Supplied Keyword: Emerging infectious diseases; Author-Supplied Keyword: Japanese encephalitis; Author-Supplied Keyword: Rift Valley fever; Author-Supplied Keyword: Venezuelan equine encephalitis; Author-Supplied Keyword: West Nile; Author-Supplied Keyword: Yellow fever; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Richard J.
AU - Ramakrishna, Gayatri
AU - Tepper, Shirley
AU - Diwan, Bhalchandra A.
AU - Anderson, Lucy M.
AU - Kritchevsky, David
T1 - Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2002/07//
VL - 64
IS - 1
M3 - Article
SP - 41
SN - 00062952
AB - Agents that either increase (cholestyramine, CS) or decrease (lovastatin, Lov) de novo peripheral cholesterol synthesis may increase (CS) or decrease (Lov) ras protein membrane localization by altering protein prenylation, and potentially have pro- or anti-carcinogenic effects. Male A/J, Swiss, and C57/BL6 mice were treated with 2 or 4% CS, 1% dietary niacin, or 25 mg/kg of Lov three times per week (Lov-3X) or five times per week (Lov-5X). After 3 weeks, serum cholesterol and triglycerides were determined enzymatically. Membrane and cytoplasmic K-ras proteins in lung were determined by immunoprecipitation followed by western blotting with a K-ras specific antibody. Results confirmed the hypothesis only in isolated instances. A/J mice had a significant 30% increase in cytoplasmic K-ras and a 40% decrease in membrane K-ras from Lov treatment, as predicted. C57/BL6 mice had a significant 77% increase in membrane K-ras, as expected from CS feeding. At variance with the hypothesis, Swiss mice had increased levels (3–28%) of membrane K-ras with all treatments (including Lov), and C57/BL6 mice treated with Lov had a 58–78% increase in cytoplasmic K-ras without any reduction in the levels of membrane K-ras. Niacin, predicted to have no effect on ras membrane localization, decreased cytoplasmic K-ras in A/J mice, increased both membrane and cytoplasmic K-ras in Swiss mice, and had no effect in C57/BL6 mice. Results may have differed from those predicted because of strain-dependent differences in response to the cholesterol-lowering agents. A difference in response among the mouse strains suggests that individual genetic differences may alter the effect of hypocholesterolemic agents on K-ras membrane localization, and potentially the risk of ras-dependent cancer. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NIACIN
KW - CHOLESTEROL
KW - THERAPEUTIC use
KW - Cholesterol
KW - Cholestyramine
KW - K-ras
KW - Lovastatin
KW - Mouse lung
KW - Niacin
N1 - Accession Number: 7839425; Calvert, Richard J. 1,2; Email Address: calvert@mail.ncifcrf.gov Ramakrishna, Gayatri 2 Tepper, Shirley 3 Diwan, Bhalchandra A. 4 Anderson, Lucy M. 2 Kritchevsky, David 3; Affiliation: 1: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC, USA 2: Laboratory of Comparative Carcinogenesis, Room 227, Building 538, National Cancer Institute at Frederick, Frederick, MD 21702, USA 3: The Wistar Institute, Philadelphia, PA 19104, USA 4: SAIC, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Source Info: Jul2002, Vol. 64 Issue 1, p41; Subject Term: NIACIN; Subject Term: CHOLESTEROL; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: Cholestyramine; Author-Supplied Keyword: K-ras; Author-Supplied Keyword: Lovastatin; Author-Supplied Keyword: Mouse lung; Author-Supplied Keyword: Niacin; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, M. W.
AU - Dombrink-Kurtzman, M. A.
AU - Tournas, V. H.
AU - White, K. D.
T1 - Occurrence of aflatoxins and fumonisins in Incaparina from Guatemala.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2002/07//
VL - 19
IS - 7
M3 - Article
SP - 671
EP - 675
PB - Taylor & Francis Ltd
SN - 0265203X
AB - The occurrence of aflatoxins and fumonisins in Incaparina was investigated. Incaparina is a mixture of corn and cottonseed flour with added vitamins, minerals and a preservative. It has been marketed as a high-protein food supplement, particularly for children on protein-deficient diets. According to estimates, 80% of Guatemalan children in their first year are given Incaparina to provide an adequate diet. Eight samples of Incaparina manufactured in Guatemala were collected. Five were from three different geographical locations in the USA and three were from Guatemala. Seven were examined for fungal contamination and analysed for aflatoxins and fumonisins. Aspergillus flavus was the predominant fungus in all samples purchased in the USA and in one sample purchased from Guatemala, whereas Fusarium verticillioides was present in only two samples (one from the USA and one from Guatemala). All samples contained aflatoxins, ranging from 3 to 214 ng g[sup -1] and <2 to 32ng g[sup -1] for aflatoxin B[sub 1] and aflatoxin B[sub 2], respectively; and one sample contained aflatoxin G[sub 1] (7 ng g[sup -1]). Total aflatoxins present ranged from 3 to 244 ng g[sup 1]. All samples contained fumonisins, ranging from 0.2 to 1.7 μg g[sup -1], <0.1 to 0.6 μg g[sup -1], and <0.1 to 0.2 μg g[sup -1] for fumonisins B[sub 1], fumonisin B[sub 2], and fumonisin B[sub 2], respectively. Total fumonisins present ranged from 0.2 to 2.2 μg g[sup -1]. The identity of aflatoxin B[sub 2] was confirmed using both the chemical derivatization method and liquid chromatographic (LC)/mass spectrometric (MS) analysis. Appropriate regulatory action was recommended for the import of Incaparina and has been in effect since 22 December 1998. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFLATOXINS
KW - FUMONISINS
KW - MYCOTOXINS
KW - GUATEMALA
KW - Aflatoxins
KW - Corn
KW - Cottonseed
KW - Fumonisins
KW - INCAPARINA
KW - Moulds
KW - Mycotoxins
N1 - Accession Number: 6943002; Trucksess, M. W. 1 Dombrink-Kurtzman, M. A. Tournas, V. H. White, K. D.; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington, DC 20204, USA; Source Info: Jul2002, Vol. 19 Issue 7, p671; Subject Term: AFLATOXINS; Subject Term: FUMONISINS; Subject Term: MYCOTOXINS; Subject Term: GUATEMALA; Author-Supplied Keyword: Aflatoxins; Author-Supplied Keyword: Corn; Author-Supplied Keyword: Cottonseed; Author-Supplied Keyword: Fumonisins; Author-Supplied Keyword: INCAPARINA; Author-Supplied Keyword: Moulds; Author-Supplied Keyword: Mycotoxins; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/02652030210125092
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Howell, Michael D.
AU - Weissman, David N.
AU - Meade, B. Jean
T1 - Latex Sensitization by Dermal Exposure Can Lead to Airway Hyperreactivity.
JO - International Archives of Allergy & Immunology
JF - International Archives of Allergy & Immunology
Y1 - 2002/07//
VL - 128
IS - 3
M3 - Article
SP - 204
EP - 211
SN - 10182438
AB - Background: Using non-powdered, low-protein natural rubber latex (NRL) gloves has been shown to reduce the elicitation of respiratory symptoms in latex-allergic individuals; however, the role of dermal exposure in the induction of sensitization is not completely understood. Objective: These studies were conducted to (1) determine levels of NRL protein in gloves currently in use and (2) evaluate, using a murine model, the potential for dermal exposure to induce NRL sensitization and subsequent airway hyperreactivity upon respiratory challenge. Methods: Total extractable protein and NRL allergen levels were evaluated from 38 glove samples using the Lowry and CAP inhibition assays, respectively. BALB/c mice were dermally exposed to non-ammoniated latex (NAL, 6.25–25 μg) 5 days/week for 13 weeks and monitored weekly/biweekly for IgE levels. Airway hyperreactivity was determined following respiratory challenge with methacholine (MCH) or NAL proteins on days 60 and 93, respectively. Results: Glove total protein and NRL allergen levels ranged from below the limit of detection to 946 μg/g and from 0.002 to 112 μg/g, respectively. Mice demonstrated dose-dependent increases in total serum IgE levels by day 58 with increased airway hyperreactivity observed upon respiratory challenge with MCH (day 60) or NAL proteins (day 93). Conclusions: These studies investigated the continued use of gloves with high levels of total extractable protein and NRL allergen. The potential for dermal exposure to induce NRL-specific IgE and airway hyperreactivity upon respiratory challenge suggests there should be continued concern regarding the induction of sensitization in individuals using non-powdered latex gloves.Copyright © 2002 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - AIRWAY (Medicine)
KW - RESPIRATION
KW - ALLERGY
KW - IMMUNOLOGIC diseases
KW - Airway hyperreactivity
KW - Dermal exposure
KW - Gloves
KW - IgE
KW - Latex allergy
KW - Murine model
KW - Natural rubber latex
N1 - Accession Number: 11335033; Howell, Michael D. 1,2 Weissman, David N. 3 Meade, B. Jean 2; Affiliation: 1: Department of Microbiology and Immunology, West Virginia University 2: Agriculture and Immunotoxicology Group 3: Analytical Services Branch, National Institute for Occupational Safety and Health, Morgantown, W.V., USA; Source Info: 2002, Vol. 128 Issue 3, p204; Subject Term: LATEX; Subject Term: AIRWAY (Medicine); Subject Term: RESPIRATION; Subject Term: ALLERGY; Subject Term: IMMUNOLOGIC diseases; Author-Supplied Keyword: Airway hyperreactivity; Author-Supplied Keyword: Dermal exposure; Author-Supplied Keyword: Gloves; Author-Supplied Keyword: IgE; Author-Supplied Keyword: Latex allergy; Author-Supplied Keyword: Murine model; Author-Supplied Keyword: Natural rubber latex; Number of Pages: 8p; Document Type: Article
L3 - 10.1159/000064253
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilkes, Jon G.
AU - Glover, Katherine L.
AU - Holcomb, Manuel
AU - Rafii, Fatemeh
AU - Cao, Xiaoxi
AU - Sutherland, John B.
AU - McCarthy, Susan A.
AU - Letarte, Simon
AU - Bertrand, Michel J.
T1 - Defining and using microbial spectral databases
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2002/07//
VL - 13
IS - 7
M3 - Article
SP - 875
SN - 10440305
AB - This work shows how fingerprints of mass spectral patterns from microbial isolates are affected by variations in instrumental condition, by sample environment, and by sample handling factors. It describes a novel method by which pattern distortions can be mathematically corrected for variations in factors not amenable to experimental control. One uncontrollable variable is “between-batch” differences in culture media. Another, relevant for determination of noncultured extracts, is differences between the cells’ environmental experience (e.g., starved environmental extracts versus cultured standards). The method suggests that, after a single growth cycle on a solid medium (perhaps, a selective one), pyrolysis MS spectra of microbial isolates can be algorithmically compensated and an unknown isolate identified using a spectral database defined by culture on a different (perhaps, nonselective) medium. This reduces identification time to as few as 24 h from sample collection. The concept also proposes a possible way to compensate certain noncultured, nonisolated samples (e.g., cells concentrated from urine or impacted from aerosol or semi-selectively extracted by immunoaffinity methods from heavily contaminated matrices) for identification within half an hour. Using the method, microbial mass spectra from different labs can be assembled into coherent databases similar to those routinely used to identify pure compounds. This type of data treatment is applicable for rapid detection in biowarfare and bioterror events as well as in forensic, research, and clinical laboratory contexts. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASS spectrometry
KW - MICROORGANISMS
KW - CULTURE media (Biology)
N1 - Accession Number: 7841751; Wilkes, Jon G. 1; Email Address: jwilkes@nctr.fda.gov Glover, Katherine L. 1 Holcomb, Manuel 1 Rafii, Fatemeh 1 Cao, Xiaoxi 1 Sutherland, John B. 1 McCarthy, Susan A. 2 Letarte, Simon 3 Bertrand, Michel J. 3; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA 2: Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama, USA 3: University of Montreal, Montreal, Canada; Source Info: Jul2002, Vol. 13 Issue 7, p875; Subject Term: MASS spectrometry; Subject Term: MICROORGANISMS; Subject Term: CULTURE media (Biology); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Eric W.
AU - Kotewicz, Michael L.
AU - Cebula, Thomas A.
T1 - Detection of recombination among Salmonella enterica strains using the incongruence length difference test
JO - Molecular Phylogenetics & Evolution
JF - Molecular Phylogenetics & Evolution
Y1 - 2002/07//
VL - 24
IS - 1
M3 - Article
SP - 102
SN - 10557903
AB - Particular serovars of Salmonella enterica have emerged as significant foodborne pathogens in humans. At the chromosomal level, discrete regions in the Salmonella genome have been identified that are known to play important roles in the maintenance, survival, and virulence of S. enterica within the host. Interestingly, several of these loci appear to have been acquired by horizontal transfer of DNA among and between bacterial species. The profound importance of recombination in pathogen emergence is just now being realized, perhaps explaining the sudden interest in developing novel and facile ways for detecting putative horizontal transfer events in bacteria. The incongruence length difference (ILD) test offers one such means. ILD uses phylogeny to trace sequences that may have been acquired promiscuously by exchange of DNA during chromosome evolution. We show here that the ILD test readily detects recombinations that have taken place in several housekeeping genes in Salmonella as well as genes composing the type 1 pilin complex (14 min) and the inv–spa invasion gene complex (63 min). Moreover, the ILD test indicated that the mutS gene (64 min), whose product helps protect the bacterial genome from invasion by foreign DNA, appears to have undergone intragenic recombination within S. enterica subspecies I. ILD findings were supported using additional tests known to be independent of the ILD approach (e.g., split decomposition analysis and compatibility of sites). Taken together, these data affirm the application of the ILD test as one approach for identifying recombined sequences in the Salmonella chromosome. Furthermore, horizontally acquired sequences within mutS support a model whereby evolutionarily important recombinants of S. enterica are rescued from strains carrying defective mutS alleles via horizontal transfer. [Copyright &y& Elsevier]
AB - Copyright of Molecular Phylogenetics & Evolution is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - BACTERIAL genetics
N1 - Accession Number: 8508031; Brown, Eric W. 1 Kotewicz, Michael L. 1 Cebula, Thomas A.; Email Address: tcebula@cfsan.fda.gov; Affiliation: 1: Division of Molecular Biology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204, USA; Source Info: Jul2002, Vol. 24 Issue 1, p102; Subject Term: SALMONELLA; Subject Term: BACTERIAL genetics; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Drachtman, Richard A.
AU - Cole, Peter D.
AU - Golden, Carla B.
AU - James, S. Jill
AU - Melnyk, Stepan
AU - Aisner, Joseph
AU - Kamen, Barton A.
T1 - DEXTROMETHORPHAN IS EFFECTIVE IN THE TREATMENT OF SUBACUTE METHOTREXATE NEUROTOXICITY.
JO - Pediatric Hematology & Oncology
JF - Pediatric Hematology & Oncology
Y1 - 2002/07//
VL - 19
IS - 5
M3 - Article
SP - 319
EP - 327
PB - Taylor & Francis Ltd
SN - 08880018
AB - Methotrexate-induced neurotoxicity (MTX-Ntox) is a frequent complication of methotrexate (MTX) therapy for patients with both malignant and inflammatory diseases. MTX-Ntox can occur after intrathecal MTX or afterlow-, intermediate-, or high-dose systemic administration. Symptoms can present in the acute, subacute, or late setting form, and can range from affective disorders, malaise, and headaches, to somnolence, focal neurologic deficits, and seizures. While the pathogenesis of MTX-Ntox is likely multifactorial, one potential biochemical pathway leading from MTX to neurotoxicity involves the folate dependent remethylation of homocysteine (Hcy). MTX therapy is known to cause elevations of both plasma and CSF Hcy. Hcy is directly toxic to vascular endothelium and it and its metabolites are excitatory agonists of the N-methyl-D-aspartate (NMDA) receptor. Competitive or noncompetitive antagonists might afford protection from or reversal of MTX-Ntox. Using high-performance liquid chromatography (HPLC) with coulometric electrochemical detection, the authors measured CSF Hcy in sequential patients with severe subacute MTX-Ntox. CSF Hcy was higher in these patients (n = 9, median = 0.93 μM) than in asymptomatic patients (n = 11, median 0.2 μM, p < .01). Five patients with severe subacute MTX-Ntox (most with dysarthria and/or hemiplegia) were treated with 1-2 mg/kg oral dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. All five had resolution of symptoms. These data provide additional clinical support for elevated CSF Hcy in the induction of MTX-Ntox through activation of the NMDA-receptor. These data provide support for a placebo-controlled clinical trial to examine the ability of DM to prevent or alleviate MTX-Ntox. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Hematology & Oncology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXICOLOGY
KW - METHOTREXATE
KW - HOMOCYSTEINE
KW - Dextromethorphan
KW - Methotrexate
KW - NEUROTOXICITY
N1 - Accession Number: 6886147; Drachtman, Richard A. 1 Cole, Peter D. 1 Golden, Carla B. 2 James, S. Jill 3 Melnyk, Stepan 3 Aisner, Joseph 4 Kamen, Barton A. 4; Affiliation: 1: Cancer Institute of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA 2: Children's Hospital Oakland, Oakland, California, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arizona, USA 4: Cancer Institute of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA; Source Info: Jul2002, Vol. 19 Issue 5, p319; Subject Term: NEUROTOXICOLOGY; Subject Term: METHOTREXATE; Subject Term: HOMOCYSTEINE; Author-Supplied Keyword: Dextromethorphan; Author-Supplied Keyword: Methotrexate; Author-Supplied Keyword: NEUROTOXICITY; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/08880010290057336
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shiming Dong
AU - Hongtao Yu
AU - Huey-Min Hwang
AU - Fu, Peter P.
T1 - Effects of Histidine on Light-Induced DNA Single-Strand Cleavage by Selected Polycyclic Aromatic Hydrocarbons.
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
Y1 - 2002/07//Jul-Oct2002
VL - 22
IS - 3/4
M3 - Article
SP - 451
EP - 458
PB - Taylor & Francis Ltd
SN - 10406638
AB - The combination of UVA light and 1-aminopyrene, 1-hydroxypyrene, 1-hydroxybenzo[ a ]pyrene, 3-aminofluoranthene, 6-aminochrysene, or 5-, 6-, and 7-methylbenz[ a ]anthracenes causes DNA single-strand cleavage. 1-Hydroxypyrene, 1-hydroxybenzo[ a ]pyrene, and 5-methylbenz[ a ]anthracene have been shown to cause DNA cleavage, at least partially, by generating singlet oxygen. Therefore, the presence of histidine, a singlet oxygen quencher, should inhibit the DNA photocleavage. However, the presence of 50 mM histidine greatly enhances the DNA photocleavage caused by these compounds. This effect is due to the inhibition of the photodegradation of the PAH compounds. Therefore, care must be taken when interpreting the singlet oxygen quenching data by histidine. Histidine may coexist with PAHs that have entered the body. The presence of histidine can alter the photochemical reaction and, possibly, the phototoxicity mechanism of the PAHs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Polycyclic Aromatic Compounds is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCYCLIC aromatic hydrocarbons
KW - PYRENE (Chemical)
KW - PHOTOCHEMISTRY
KW - DNA
KW - ACTIVE oxygen
KW - DNA cleavage
KW - histidine
KW - PAH
KW - singlet oxygen
KW - UVA light
N1 - Accession Number: 11551194; Shiming Dong 1 Hongtao Yu 1 Huey-Min Hwang 2 Fu, Peter P. 3; Affiliation: 1: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA 2: Department of Biology, Jackson State University, Jackson, Mississippi, USA 3: National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Jul-Oct2002, Vol. 22 Issue 3/4, p451; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: PYRENE (Chemical); Subject Term: PHOTOCHEMISTRY; Subject Term: DNA; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: DNA cleavage; Author-Supplied Keyword: histidine; Author-Supplied Keyword: PAH; Author-Supplied Keyword: singlet oxygen; Author-Supplied Keyword: UVA light; Number of Pages: 8p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/10406630290103663
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kui Zeng
AU - Huey-Min Hwang
AU - Fu, Peter P.
AU - Hongtao Yu
T1 - Identification of 1-Hydroxypyrene Photoproducts and Study of the Effect of Humic Substances on its Photolysis.
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
Y1 - 2002/07//Jul-Oct2002
VL - 22
IS - 3/4
M3 - Article
SP - 459
EP - 467
PB - Taylor & Francis Ltd
SN - 10406638
AB - Photolysis products of 1-hydroxypyrene (1-HP) were identified by liquid chromatography coupled with mass spectrometry (LC/MS/MS). It was found that the major photoproducts of 1-HP are 1,6-, 1,8-, and one unidentified pyrene quinone and one pyrene quinone dimer based on their HPLC chromatogram and mass spectral data. The photolysis of 1-HP was conducted with pure water, natural river water, and pure water containing commercial humic substances. It was found that the photolysis rate of 1-HP can be inhibited by humic substances, depending on their type and concentration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Polycyclic Aromatic Compounds is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PYRENE (Chemical)
KW - PHOTOAFFINITY labeling
KW - PHOTOCHEMISTRY
KW - QUINONE
KW - DIMERS
KW - 1-hydroxypyrene
KW - degradation
KW - humic substance
KW - light
KW - photoproduct
N1 - Accession Number: 11551239; Kui Zeng 1 Huey-Min Hwang 1 Fu, Peter P. 2 Hongtao Yu 3; Affiliation: 1: Department of Biology, Jackson State University, Jackson, Mississippi, USA 2: National Center for Toxicological Research, Jefferson, Arkansas, USA 3: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA; Source Info: Jul-Oct2002, Vol. 22 Issue 3/4, p459; Subject Term: PYRENE (Chemical); Subject Term: PHOTOAFFINITY labeling; Subject Term: PHOTOCHEMISTRY; Subject Term: QUINONE; Subject Term: DIMERS; Author-Supplied Keyword: 1-hydroxypyrene; Author-Supplied Keyword: degradation; Author-Supplied Keyword: humic substance; Author-Supplied Keyword: light; Author-Supplied Keyword: photoproduct; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1080/10406630290103672
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fu, Peter P.
AU - Von Tungeln, Linda S.
AU - Qingsu Xia, Linda S.
AU - De-Jin Zhan, Linda S.
AU - Heflich, Robert H.
T1 - Effect of Nitro Orientation on Ras -Protooncogene Mutation in Liver Tumors from 7-Nitrodibenz[ a,h ]anthracene-Treated Mice.
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
Y1 - 2002/07//Jul-Oct2002
VL - 22
IS - 3/4
M3 - Article
SP - 853
EP - 859
PB - Taylor & Francis Ltd
SN - 10406638
AB - Dibenz[ a,h ]anthracene (DB[ a,h ]A) and 7-nitrodibenz[ a,h ]anthracene (7-NDB[ a,h ]A) induced liver tumors when administered to neonatal B6C3F 1 mice. For protooncogene analysis, RNA was isolated from each of the liver tumors from treated mice and reverse-transcribed into cDNA. Portions of the K- and H- ras protein coding sequences were then amplified and analyzed for DNA sequence alterations. DB[ a,h ]A-induced liver tumors had a 100% (23/23) frequency of ras -protooncogene mutation, with 83% (19/23) occurring at the first base of K- ras codon 13 and resulting in G GC → C GC transversion; the remaining 17% (4/23) of the mutations were located at the second base of H- ras codon 61. In contrast, only four of nine (44%) of 7-NDB[ a,h ]A-induced liver tumors had ras -protooncogene mutations, with two each at K- ras codon 13 and H- ras codon 61. Combined with previous observations, the results indicate that the nitro substituent perpendicular to the aromatic moiety alters the chemical-induced protooncogene activation frequency and mutational pattern in liver tumors of B6C3F 1 mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Polycyclic Aromatic Compounds is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOGENES
KW - LIVER tumors
KW - ANTHRACENE
KW - MUTATION (Biology)
KW - STRUCTURE-activity relationships (Biochemistry)
KW - GENETIC toxicology
KW - 7-nitrodibenz[ a,h ]anthracene
KW - dibenz[ a,h ]anthracene
KW - K- ras oncogene
KW - liver tumors
KW - neonatal mouse
KW - nitro orientation
N1 - Accession Number: 11551220; Fu, Peter P. 1 Von Tungeln, Linda S. 1 Qingsu Xia, Linda S. 1 De-Jin Zhan, Linda S. 1 Heflich, Robert H. 1; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Jul-Oct2002, Vol. 22 Issue 3/4, p853; Subject Term: ONCOGENES; Subject Term: LIVER tumors; Subject Term: ANTHRACENE; Subject Term: MUTATION (Biology); Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: GENETIC toxicology; Author-Supplied Keyword: 7-nitrodibenz[ a,h ]anthracene; Author-Supplied Keyword: dibenz[ a,h ]anthracene; Author-Supplied Keyword: K- ras oncogene; Author-Supplied Keyword: liver tumors; Author-Supplied Keyword: neonatal mouse; Author-Supplied Keyword: nitro orientation; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1080/10406630290104004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongtao Yu
AU - Shiming Dong
AU - Fu, Peter P.
AU - Huey-Min Hwang
T1 - UVA Light-Induced DNA Single-Strand Cleavage by Hydroxybenzo[ a ]pyrenes.
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
Y1 - 2002/07//Jul-Oct2002
VL - 22
IS - 3/4
M3 - Article
SP - 861
EP - 870
PB - Taylor & Francis Ltd
SN - 10406638
AB - UVA light-induced DNA single-strand cleavage by 1-hydroxy, 3-hydroxy, 7-hydroxy, and 9-hydroxybenzo[ a ]pyrenes (OH-B a Ps) and 6-acetoxybenzo[ a ]pyrene (6-OAc-B a P) was studied. Under experimental conditions, the concentrations of 1-OH, 3-OH, 7-OH, and 9-OH-B a Ps and 6-OAc-B a P needed to cause 25% of the supercoiled form I plasmid DNA to become relaxed form II DNA were found to be 0.6, 2.5, 1.0, 1.3, and 1.1 μM, respectively. These concentrations are all smaller than that of B a P, which was 6 μM. These results indicate that on photoirradiation, OH-B a Ps are more cytotoxic and/or genotoxic than their parent compound, B a P. Mechanistic studies reveal that singlet oxygen and superoxide free radicals are involved in causing DNA cleavage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Polycyclic Aromatic Compounds is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOL
KW - PYRENE (Chemical)
KW - DNA
KW - POLYCYCLIC aromatic hydrocarbons
KW - METABOLITES
KW - benzo[ a ]pyrene
KW - DNA cleavage
KW - hydroxybenzo[ a ]pyrenes
KW - light
KW - metabolites
KW - PAH
N1 - Accession Number: 11551242; Hongtao Yu 1 Shiming Dong 1 Fu, Peter P. 2 Huey-Min Hwang 3; Affiliation: 1: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA 2: National Center for Toxicological Research, Jefferson, Arkansas, USA 3: Department of Biology, Jackson State University, Jackson, Mississippi, USA; Source Info: Jul-Oct2002, Vol. 22 Issue 3/4, p861; Subject Term: PHENOL; Subject Term: PYRENE (Chemical); Subject Term: DNA; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: METABOLITES; Author-Supplied Keyword: benzo[ a ]pyrene; Author-Supplied Keyword: DNA cleavage; Author-Supplied Keyword: hydroxybenzo[ a ]pyrenes; Author-Supplied Keyword: light; Author-Supplied Keyword: metabolites; Author-Supplied Keyword: PAH; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 2 Graphs; Document Type: Article
L3 - 10.1080/10406630290104013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maiese, Deborah R.
T1 - Healthy people 2010—leading health indicators for women
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2002/07//Jul/Aug2002
VL - 12
IS - 4
M3 - Article
SP - 155
SN - 10493867
AB - To examine the health status of women in relationship to the targets for the Healthy People 2010 ten Leading Health Indicators (LHIs), this paper compares females and males, as well as females by age groups. The data presented in this study were collected from publicly available sources, including Healthy People 2010 publications and websites, as well as Health US 2000. In addition, the lead agency Department of Health and Human Services workgroup coordinators provided clarifying information. Women were found to have better health status than men on half of the LHIs. When examined by age, data for the LHIs provide additional insights on where to target interventions to improve women’s health. For adolescent females, the biggest challenges to meet the year 2010 targets are in reducing tobacco use, obesity, motor vehicle deaths, and homicides. For adult females, the greatest public health challenges are in increasing physical activity, reducing obesity, and obtaining immunizations. [Copyright &y& Elsevier]
AB - Copyright of Women's Health Issues is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN -- Health
KW - HEALTH status indicators
N1 - Accession Number: 7835504; Maiese, Deborah R. 1; Affiliation: 1: Office of Women’s Health, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland, USA; Source Info: Jul/Aug2002, Vol. 12 Issue 4, p155; Subject Term: WOMEN -- Health; Subject Term: HEALTH status indicators; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Heller, David N.
AU - Ngoh, Maureen A.
AU - Donoghue, Dan
AU - Podhorniak, Lynda
AU - Righter, Herbert
AU - Thomas, Michael H.
T1 - Identification of incurred sulfonamide residues in eggs: methods for confirmation by liquid chromatography–tandem mass spectrometry and quantitation by liquid chromatography with ultraviolet detection
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2002/07/05/
VL - 774
IS - 1
M3 - Article
SP - 39
SN - 15700232
AB - Two complementary methods for identifying and measuring sulfonamide residues in eggs were developed for use in surveying eggs for potential drug residues. The first method uses liquid chromatography–tandem mass spectrometry (LC–MS–MS) to confirm the presence of sulfonamide residues in eggs. During its validation the limit of confirmation was estimated to be 5–10 ng/g (ppb) depending on the drug. Also, a method for measuring residue level by liquid chromatography with ultraviolet detection (LC–UV) was validated using the same extraction procedure as the confirmatory method. The determinative method was validated over the 50–200 ppb range. Samples were prepared by homogenizing whole egg, extracting with acetonitrile, and cleaning up with a C18 solid-phase extraction cartridge. For confirmation, analytes were separated by gradient LC on a C18 column, ionized by electrospray ionization (ESI), and detected by MS–MS with an ion trap mass spectrometer. For determination, analytes were separated by a different gradient LC procedure and detected by UV at 287 nm. Fifteen drugs were dosed individually in laying hens, and residues of parent drug and/or metabolites were found in eggs for all the drugs. Validation was based on repetitive analyses of control samples, control samples fortified at 100 ppb sulfonamides, and samples of blended incurred eggs. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SULFONAMIDES
KW - LIQUID chromatography
KW - MASS spectrometry
KW - Sulfonamides
N1 - Accession Number: 7815305; Heller, David N. Ngoh, Maureen A. Donoghue, Dan Podhorniak, Lynda Righter, Herbert 1 Thomas, Michael H. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708, USA; Source Info: Jul2002, Vol. 774 Issue 1, p39; Subject Term: SULFONAMIDES; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Sulfonamides; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang, Jung Yun
AU - Oh, Yu-Kyoung
AU - Choi, Han-gon
AU - Kim, Yang Bae
AU - Kim, Chong-Kook
T1 - Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2002/07/08/
VL - 241
IS - 1
M3 - Article
SP - 155
SN - 03785173
AB - The timely gelation and retention of in situ-gelling vaginal formulations would be fundamental to improve the efficacy of drugs. In this study, various rheological properties of clotrimazole gels were evaluated for predicting their performance in vagina. Two kinds of thermosensitive and mucoadhesive formulations were composed of poloxamer 407 (P407, 15%), polycarbophil (0.2%), and different amounts of P188 (15 vs. 20%). Both formulations were Newtonian at 20 °C but non-Newtonian at 37 °C. Although both liquid formulations gelled below the vaginal temperature, they differed in gelation time and viscoelastic properties in the presence of vaginal fluid simulant. At body temperature, the formulation with 20% of P188 gelled within 35 s but it took two times longer for the other one gelled. Upon dilution with simulated vaginal fluid, the formulation with 20% of P188 retained the rheology of a gel, but the other one lost the viscoelastic properties typical for a gel. Moreover, after dilution with simulated vaginal fluid, the elastic modulus was orders of magnitude higher in the formulations with 20% of P188 relative to the other one. These results indicate that the rheological evaluation at the physiologic conditions needs to be preceded to develop more effective in situ-gelling vaginal formulations. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHEOLOGY
KW - GELATION
KW - Clotrimazole
KW - Poloxamer
KW - Rheology
KW - Thermosensitive gel
KW - Vaginal formulation
N1 - Accession Number: 7830502; Chang, Jung Yun 1,2 Oh, Yu-Kyoung 3 Choi, Han-gon 4 Kim, Yang Bae 1 Kim, Chong-Kook 1; Email Address: ckkim@plaza.snu.ac.kr; Affiliation: 1: National Research Laboratory for Drug and Gene Delivery, College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Ku, Seoul 151-742, South Korea 2: Division of Antibiotics, Korea Food and Drug Administration, Seoul 122-704, South Korea 3: College of Medicine and Institute of Medical Research, Pochon CHA University, Kyonggi-do, South Korea 4: College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyongsan 712-749, South Korea; Source Info: Jul2002, Vol. 241 Issue 1, p155; Subject Term: RHEOLOGY; Subject Term: GELATION; Author-Supplied Keyword: Clotrimazole; Author-Supplied Keyword: Poloxamer; Author-Supplied Keyword: Rheology; Author-Supplied Keyword: Thermosensitive gel; Author-Supplied Keyword: Vaginal formulation; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coles, Brian F.
AU - Chen, Guanping
AU - Kadlubar, Fred. F.
AU - Radominska-Pandya, Anna
T1 - Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu, and pi expression in gastrointestinal tract mucosa of normal individuals
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2002/07/15/
VL - 403
IS - 2
M3 - Article
SP - 270
SN - 00039861
AB - Glutathione S-transferase (GST) protein in gastrointestinal (GI) tracts of 16 organ donors, from whom all or substantial portions of the GI tract (stomach–colon) were available, was quantitated by HPLC and examined for interindividual variability/consistency of organ-specific patterns of expression. GSTP1, GSTA1, and GSTA2 were major components, and GSTM1 and GSTM3 were minor components. Consistent patterns of organ-specific expression were evident despite a high degree of interindividual variation of expression. GSTP1 was expressed throughout the GI tract and showed a decrease of expression from stomach to colon. GSTA1 and GSTA2 were expressed at high levels in duodenum and small intestine and expression decreased from proximal to distal small intestine. In contrast, GSTA1 and GSTA2 expression in colon and stomach of all subjects was low, particularly for colon where GSTA1 expression was 20- to 800-fold lower than that in corresponding small intestine. These consistent patterns of expression would suggest that compared to duodenum and small intestine, colon and to a lesser extent stomach always have low potential for GST-dependent detoxification of chemical carcinogens and are therefore at greater risk of genotoxic effects, particularly via substrates that are specific for GSTA1. This may be a factor in the greater susceptibility of stomach and colon to cancers compared to duodenum/small intestine. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE transferase
KW - GASTROINTESTINAL system
KW - Carcinogenesis
KW - Colon
KW - Duodenum
KW - GI tract
KW - Glutathione S-transferase
KW - Human
KW - Protein expression
KW - Small intestine
KW - Stomach
N1 - Accession Number: 8508088; Coles, Brian F. 1; Email Address: bcoles@nctr.fda.gov Chen, Guanping 2 Kadlubar, Fred. F. 1 Radominska-Pandya, Anna 2; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Source Info: Jul2002, Vol. 403 Issue 2, p270; Subject Term: GLUTATHIONE transferase; Subject Term: GASTROINTESTINAL system; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Colon; Author-Supplied Keyword: Duodenum; Author-Supplied Keyword: GI tract; Author-Supplied Keyword: Glutathione S-transferase; Author-Supplied Keyword: Human; Author-Supplied Keyword: Protein expression; Author-Supplied Keyword: Small intestine; Author-Supplied Keyword: Stomach; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jedynak, Jakub P.
AU - Ali, Syed F.
AU - Haycock, John W.
AU - Hope, Bruce T.
T1 - Acute administration of cocaine regulates the phosphorylation of serine-19, -31 and -40 in tyrosine hydroxylase.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2002/07/15/
VL - 82
IS - 2
M3 - Article
SP - 382
EP - 388
PB - Wiley-Blackwell
SN - 00223042
AB - Abstract Acute cocaine can inhibit catecholamine biosynthesis by regulating the enzymatic activity of tyrosine hydroxylase via alterations in the phosphorylation state of the enzyme. The mechanisms underlying acute cocaine-dependent regulation of tyrosine hydroxylase phosphorylation have not been determined. In this study, 0, 15 or 30 mg/kg cocaine was administered intraperitoneally to rats and the phosphorylation state of tyrosine hydroxylase in the brain was examined using antibodies specific for the phosphorylated forms of serine-19, -31 and -40 in tyrosine hydroxylase. In the caudate and nucleus accumbens, cocaine dose-dependently decreased the levels of phosphorylated serine-19, -31 and -40. In the ventral tegmental area, the levels of phosphorylated serine-19, but not serine-31 and -40, were decreased by 15 and 30 mg/kg cocaine. In the amygdala, the levels of phosphorylated serine-19, but not serine-31 or -40, were decreased. The functional effects of these alterations in phosphorylation state were assessed by measuring tyrosine hydroxylase activity in vivo(accumulation of DOPA after administration of the decarboxylase inhibitor NSD-1015). Acute administration of 30 mg/kg cocaine significantly decreased l-DOPA production in caudate and accumbens but not in amygdala. These data suggest that the phosphorylation of serine-31 or -40, but not serine-19, is involved in the regulation of tyrosine hydroxylase activity by acute cocaine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCAINE
KW - PHOSPHORYLATION
KW - SERINE
KW - TYROSINE
KW - amygdala
KW - caudate
KW - dopamine
KW - nucleus accumbens
KW - ventral tegmental area
N1 - Accession Number: 6911256; Jedynak, Jakub P. 1 Ali, Syed F. 2 Haycock, John W. 3 Hope, Bruce T. 1; Affiliation: 1: Behavioral Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, USA 2: National Center for Toxicological Research, US FDA, Jefferson, Arkansas, USA 3: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA; Source Info: 7/15/2002, Vol. 82 Issue 2, p382; Subject Term: COCAINE; Subject Term: PHOSPHORYLATION; Subject Term: SERINE; Subject Term: TYROSINE; Author-Supplied Keyword: amygdala; Author-Supplied Keyword: caudate; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: nucleus accumbens; Author-Supplied Keyword: ventral tegmental area; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1046/j.1471-4159.2002.00982.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi, Ping
AU - Pogribny, Igor P.
AU - Jill James, S.
T1 - Multiplex PCR for simultaneous detection of 677 C→T and 1298 A→C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/07/26/
VL - 181
IS - 2
M3 - Article
SP - 209
SN - 03043835
AB - Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis. Because aberrations in both of these pathways can be tumor promoting, the two common polymorphisms in the MTHFR gene, 677 C→T and 1298 A→C, have been implicated as risk factors for several cancers. Homozygosity for the 677 C→T polymorphism and compound heterozygosity for 677 C→T and 1298 A→C polymorphisms both reduce enzyme activity by more than 50% and can promote oncogenic alterations in DNA methylation especially when folate status is low. Thus, rapid identification of both polymorphisms in MTHFR gene would be of importance in understanding the genetics of abnormal folate metabolism as related to human cancer risk. Here we describe a multiplex polymerse chain reaction/restriction fragment length polymorphism procedure in which two sets of primers are used to amplify simultaneously the DNA regions spanning 677 and 1298 loci in one PCR reaction. The amplified products are digested by HinfI or MboII followed by agarose gel electrophoresis for simultaneous detection of the 677 C→T and 1298 A→C polymorphisms in the same gel. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - GENETIC polymorphisms
KW - Cancer risk
KW - Folate
KW - Methylenetetrahydrofolate reductase
KW - Multiplex polymerase chain reaction
N1 - Accession Number: 7804612; Yi, Ping 1 Pogribny, Igor P. 1 Jill James, S.; Email Address: jjames@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, Food and Drug Administration – National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Jul2002, Vol. 181 Issue 2, p209; Subject Term: POLYMERASE chain reaction; Subject Term: GENETIC polymorphisms; Author-Supplied Keyword: Cancer risk; Author-Supplied Keyword: Folate; Author-Supplied Keyword: Methylenetetrahydrofolate reductase; Author-Supplied Keyword: Multiplex polymerase chain reaction; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Corrêa-Oliveira, Rodrigo
AU - Golgher, Denise B.
AU - Oliveira, Guilherme C.
AU - Carvalho, Omar S.
AU - Massara, Cristiano L.
AU - Caldas, Iramaya R.
AU - Colley, Daniel G.
AU - Gazzinelli, Giovanni
T1 - Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookworm
JO - Acta Tropica
JF - Acta Tropica
Y1 - 2002/08//
VL - 83
IS - 2
M3 - Article
SP - 123
SN - 0001706X
AB - Studies were performed on humoral and cellular immune responses of patients from areas in Brazil endemic for hookworm and Ascaris lumbricoides, and either endemic or non-endemic for Schistosoma mansoni. Humoral and cellular responses were evaluated by enzyme-linked immunosorbant assay (ELISA) and peripheral blood mononuclear cell (PBMC) proliferation assays against larval hookworm antigens, A. lumbricoides egg antigens, and soluble egg antigens (SEA) or soluble whole adult antigenic preparation (SWAP) from S. mansoni. Patients from S. mansoni-endemic areas, who currently had only hookworm or Ascaris infections, expressed lower humoral and cellular responses to hookworm or Ascaris antigens, respectively, than did their counterparts from areas not endemic for S. mansoni. Individuals from S. mansoni endemic area, although without detectable S. mansoni infection, do mount humoral and cellular responses to SEA and SWAP. This group of individuals has been probably in contact with S. mansoni antigens, since the groups harboring A. lumbricoides or hookworm infections from non-S. mansoni endemic areas do not have detectable anti-S. mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for S. mansoni. [Copyright &y& Elsevier]
AB - Copyright of Acta Tropica is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHISTOSOMA mansoni
KW - IMMUNE response
KW - BRAZIL
KW - Antibodies
KW - Ascaris lumbricoides
KW - Hookworm
KW - PBMC proliferation
KW - Schistosoma mansoni
N1 - Accession Number: 7831169; Corrêa-Oliveira, Rodrigo 1; Email Address: correa@cpqrr.fiocruz.br Golgher, Denise B. 1 Oliveira, Guilherme C. 1,2 Carvalho, Omar S. 1 Massara, Cristiano L. 1 Caldas, Iramaya R. 1 Colley, Daniel G. 3 Gazzinelli, Giovanni 1,2; Affiliation: 1: Lab. de Immunologia Celular e Molecular, Centro de Pesquisas René Rachou-FIOCRUZ, Av. Augusto de Lima 1715 Barro Preto, Belo Horizonte, MG, 30190-002, Brazil 2: Programa de Pós-Graduação da Santa Casa de Misericórdia de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, 30150-221, Brazil 3: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341, USA; Source Info: Aug2002, Vol. 83 Issue 2, p123; Subject Term: SCHISTOSOMA mansoni; Subject Term: IMMUNE response; Subject Term: BRAZIL; Author-Supplied Keyword: Antibodies; Author-Supplied Keyword: Ascaris lumbricoides; Author-Supplied Keyword: Hookworm; Author-Supplied Keyword: PBMC proliferation; Author-Supplied Keyword: Schistosoma mansoni; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campos-Outcalt, Doug
AU - Bay, Curt
AU - Dellapenna, Alan
AU - Cota, Marya K.
T1 - Pedestrian fatalities by race/ethnicity in Arizona, 1990–1996
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2002/08//
VL - 23
IS - 2
M3 - Article
SP - 129
SN - 07493797
AB - Purpose: To explore rates of pedestrian fatalities in Arizona, and how rates and circumstances of pedestrian deaths differ by race/ethnicity, urban or rural residence, age, and gender.Methods: Using the Fatality Analysis Reporting System and the National Center for Health Statistics’ Multiple Cause of Death file, pedestrian fatalities in Arizona from 1990 through 1996 were classified by gender, race/ethnicity, and urban or rural residence. Age-adjusted rates were calculated and adjusted for the proportion of rural residence. Age analyses compared pedestrian fatality rates in 10-year age groups by race/ethnicity. Conditions associated with pedestrian deaths were examined, including the time and day of occurrence, alcohol involvement, and degree of pedestrian contribution to the crash.Results: American Indians had rates of pedestrian deaths 6 to 13 times those of non-Hispanic whites. Elevated rates for American Indians were found in urban and rural areas, in both genders, in all age groups in men, and in five of nine age groups in women. American-Indian pedestrian death rates and relative risks (RRs) were higher in rural areas than in urban areas. Compared to non-Hispanic whites, urban Hispanic males had an elevated RR of 1.56, rural Hispanic females had an RR of 2.45, and urban African-American (AA) females had an RR of 2.33. However, significantly elevated rates, compared to non-Hispanic whites, were limited to Hispanic males aged <5 years and African-American females aged 65 to 74 years. In all race/ethnic groups, except rural Hispanics, men had higher rates than women, although American-Indian women had higher rates than non-Hispanic whites, African Americans, and Hispanic men.Rural residence accounted for 27% of the excess American-Indian pedestrian mortality. Sixty-one percent of urban, American-Indian pedestrian deaths occurred on weekends, compared to 29% among non-Hispanic whites and 46% among Hispanics. American Indians had six times the rate of alcohol-related pedestrian deaths as non-Hispanic whites in urban areas and 16 times that respective rate in rural areas. Hispanics had an alcohol- involvement RR of 1.82 in urban areas, but the RR was not elevated in rural areas. When blood alcohol was measured, the blood alcohol concentration was >0.20 g/dL in 64.4% of American Indians, 35% of Hispanics, and 29% of non-Hispanic whites.Conclusion: A major disparity in pedestrian fatalities exists for both American-Indian men and women in urban and rural areas. Other racial/ethnic groups have elevated pedestrian fatality rates that are gender and residence specific, and are limited to specific age groups. Much of the American-Indian excess mortality is alcohol related and associated with residence in rural areas. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDESTRIAN accidents
KW - TRAFFIC safety
KW - ARIZONA
KW - UNITED States
KW - accidents
KW - alcoholic intoxication
KW - ethnic groups
KW - Hispanic Americans
KW - motor vehicle crashes
KW - North American Indians
KW - traffic accidents
N1 - Accession Number: 7842559; Campos-Outcalt, Doug 1; Email Address: dougcampos@mail.maricopa.gov Bay, Curt 2 Dellapenna, Alan 3 Cota, Marya K. 4; Affiliation: 1: Maricopa County Department of Public Health (Campos-Outcalt), Phoenix, Arizona, USA 2: Department of Academic Affairs (Bay), Maricopa Integrated Health System, Phoenix, Arizona, USA 3: Division of Environmental Health Services, Indian Health Service (Dellapenna), Rockville, Maryland, USA 4: Department of Psychiatry and Psychiatry Residency Program (Cota), Maricopa Integrated Health System, Phoenix, Arizona, USA; Source Info: Aug2002, Vol. 23 Issue 2, p129; Subject Term: PEDESTRIAN accidents; Subject Term: TRAFFIC safety; Subject Term: ARIZONA; Subject Term: UNITED States; Author-Supplied Keyword: accidents; Author-Supplied Keyword: alcoholic intoxication; Author-Supplied Keyword: ethnic groups; Author-Supplied Keyword: Hispanic Americans; Author-Supplied Keyword: motor vehicle crashes; Author-Supplied Keyword: North American Indians; Author-Supplied Keyword: traffic accidents; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bartley, David L.
AU - Ogden, Trevor
AU - Song, Ruiguang
T1 - Frequency distributions from birth, death, and creation processes
JO - Biosystems
JF - Biosystems
Y1 - 2002/08//
VL - 66
IS - 3
M3 - Article
SP - 179
SN - 03032647
AB - The time-dependent frequency distribution of groups of individuals versus group size was investigated within a continuum approximation, assuming a simplified individual growth, death and creation model. The analogy of the system to a physical fluid exhibiting both convection and diffusion was exploited in obtaining various solutions to the distribution equation. A general solution was approximated through the application of a Green''s function. More specific exact solutions were also found to be useful. The solutions were continually checked against the continuum approximation through extensive simulation of the discrete system. Over limited ranges of group size, the frequency distributions were shown to closely exhibit a power-law dependence on group size, as found in many realizations of this type of system, ranging from colonies of mutated bacteria to the distribution of surnames in a given population. As an example, the modeled distributions were successfully fit to the distribution of surnames in several countries by adjusting the parameters specifying growth, death and creation rates. [Copyright &y& Elsevier]
AB - Copyright of Biosystems is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDBIRTH
KW - DEATH
KW - DISTRIBUTION (Probability theory)
KW - PERSONAL names
KW - Bateman
KW - Birth
KW - Creation
KW - Death
KW - Kummer
KW - Pareto
KW - Power-law
KW - Skewed distribution
KW - Surname
KW - Zipf
N1 - Accession Number: 7912306; Bartley, David L. 1 Ogden, Trevor 2 Song, Ruiguang 3; Affiliation: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: 40 Wilsham Road, Abingdon, Oxfordshire OX14 5LE, UK 3: Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA; Source Info: Aug2002, Vol. 66 Issue 3, p179; Subject Term: CHILDBIRTH; Subject Term: DEATH; Subject Term: DISTRIBUTION (Probability theory); Subject Term: PERSONAL names; Author-Supplied Keyword: Bateman; Author-Supplied Keyword: Birth; Author-Supplied Keyword: Creation; Author-Supplied Keyword: Death; Author-Supplied Keyword: Kummer; Author-Supplied Keyword: Pareto; Author-Supplied Keyword: Power-law; Author-Supplied Keyword: Skewed distribution; Author-Supplied Keyword: Surname; Author-Supplied Keyword: Zipf; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rathbone, Michael J.
AU - Martinez, Marilyn N.
T1 - Modified release drug delivery in veterinary medicine
JO - Drug Discovery Today
JF - Drug Discovery Today
Y1 - 2002/08//
VL - 7
IS - 15
M3 - Article
SP - 823
SN - 13596446
AB - To successfully research and develop an animal pharmaceutical dosage form, a diverse array of issues covering basic medicine, pharmacology and technology must be addressed. Societal concerns regarding animal and public health, as well as the rapidly changing farming and economic environments, provide additional challenges that require integration into an already complex web of issues. Here, we examine the drive towards reducing the frequency of administration to animals and the closing of gaps between the human and veterinary drug product development. [Copyright &y& Elsevier]
AB - Copyright of Drug Discovery Today is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOLOGY
KW - PUBLIC health
KW - DRUG development
N1 - Accession Number: 7858064; Rathbone, Michael J. 1; Email Address: mjr@interag1.co.nz Martinez, Marilyn N. 2; Affiliation: 1: InterAg558 Te Rapa Road, PO Box 20055 Hamilton, New Zealand tel: +64 7838 5090, fax: +64 7838 5070 2: Center for Veterinary Medicine, HFV-130Food and Drug Administration, Rockville, MD 20855, USA; Source Info: Aug2002, Vol. 7 Issue 15, p823; Subject Term: PHARMACOLOGY; Subject Term: PUBLIC health; Subject Term: DRUG development; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reutman, Susan R.
AU - LeMasters, Grace Kawas
AU - Kesner, James S.
AU - Shukla, Rakesh
AU - Krieg Jr, Edward F.
AU - Knecht, Edwin A.
AU - Lockey, James E.
T1 - Urinary reproductive hormone level differences between African American and Caucasian women of reproductive age
JO - Fertility & Sterility
JF - Fertility & Sterility
Y1 - 2002/08//
VL - 78
IS - 2
M3 - Article
SP - 383
SN - 00150282
AB - Objective: To compare urinary levels of reproductive hormones in African American and Caucasian women.Design: Cross-sectional study.Setting: Ten United States Air Force (USAF) bases.Patient(s): African American (n = 33) and Caucasian (n = 65) women of reproductive age from a larger study of USAF women (n = 170).Intervention(s): None.Main Outcome Measure(s): Urinary endocrine end points: follicular luteinizing hormone (LH), preovulatory LH, level of LH surge peak, early follicular follicle stimulating hormone (FSH), follicular LH:FSH ratio, midluteal FSH, FSH rise before menses, early follicular estrone 3-glucuronide (E13G), midfollicular E13G, periovulatory E13G peak, midluteal E13G, early follicular pregnanediol 3-glucuronide (Pd3G), follicular Pd3G, rate of periovulatory Pd3G increase, E13G:Pd3G on the day of luteal transition, slope of E13G:Pd3G, and midluteal Pd3G.Result(s): Relative to Caucasians, African American women had significantly lower follicular phase LH:FSH ratios (mean ± SD: 0.7 ± 0.4 vs. 1.0 ± 0.6), lower follicular phase Pd3G levels (1.0 ± 0.5 vs. 1.2 ± 0.8 μg/mg creatinine), and lower rates of periovulatory Pd3G increase (0.5 ± 0.7 vs. 1.0 ± 1.2 μg/mg creatinine).Conclusion(s): Findings of this analysis should be considered preliminary evidence of racial differences in hormone levels. Future studies are needed to determine whether these differences have clinical significance. [Copyright &y& Elsevier]
AB - Copyright of Fertility & Sterility is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUTEINIZING hormone
KW - PROGESTERONE
KW - ESTROGEN
KW - FOLLICLE-stimulating hormone
KW - African Americans
KW - Caucasians
KW - epidemiology
KW - estrogen
KW - follicle stimulating hormone
KW - Hormones
KW - luteinizing hormone
KW - progesterone
KW - racial differences
KW - reproduction
N1 - Accession Number: 7852544; Reutman, Susan R. 1; Email Address: ereutman@hotmail.com LeMasters, Grace Kawas 1 Kesner, James S. 2 Shukla, Rakesh 1 Krieg Jr, Edward F. 2 Knecht, Edwin A. 2 Lockey, James E. 1; Affiliation: 1: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio USA 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health of the Centers for Disease Control, Cincinnati, Ohio USA; Source Info: Aug2002, Vol. 78 Issue 2, p383; Subject Term: LUTEINIZING hormone; Subject Term: PROGESTERONE; Subject Term: ESTROGEN; Subject Term: FOLLICLE-stimulating hormone; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: Caucasians; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: estrogen; Author-Supplied Keyword: follicle stimulating hormone; Author-Supplied Keyword: Hormones; Author-Supplied Keyword: luteinizing hormone; Author-Supplied Keyword: progesterone; Author-Supplied Keyword: racial differences; Author-Supplied Keyword: reproduction; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn
AU - Simpson, Lisa
T1 - Looking Forward to Impact: Moving Beyond Serendipity.
JO - Health Services Research
JF - Health Services Research
Y1 - 2002/08//
VL - 37
IS - 4
M3 - Article
SP - xiv
EP - xxiii
PB - Wiley-Blackwell
SN - 00179124
AB - Discusses how the Agency for Healthcare Research and Quality-supported research impacts the health care system in the U.S. Impact of the Government Performance and Results Act of 1993 on the agency's accountability; Examples of the how the agency puts research into practice; Challenges for health service researchers.
KW - MEDICAL care
KW - UNITED States
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 11650278; Clancy, Carolyn 1 Simpson, Lisa 1; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ); Source Info: Aug2002, Vol. 37 Issue 4, pxiv; Subject Term: MEDICAL care; Subject Term: UNITED States; Company/Entity: UNITED States. Agency for Healthcare Research & Quality; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burkhardt, W
AU - Blackstone, G.M
AU - Skilling, D
AU - Smith, A.W
T1 - Applied technique for increasing calicivirus detection in shellfish extracts.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2002/08//
VL - 93
IS - 2
M3 - Article
SP - 235
EP - 240
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: Optimal detection of enteric RNA viruses in clinical, environmental, and food products using reverse transcription-PCR (RT-PCR) when inhibitory substances in extracted sample materials are present. Methods and Results: We adapted a device for detection of RNA viruses in plant tissues and insects to detect a calicivirus strain (San Miguel sea lion virus, serotype 17) in water and oyster tissue extracts. This single, compartmentalized tube-within-a-tube (TWT) device for RT-PCR-nested PCR was compared to a conventional protocol of RT-PCR-nested PCR. In the presence of 100 mg of shellfish tissue extract equivalent, this TWT device decreases the calicivirus assay detection limit 10-fold over that of conventional RT-PCR-nested PCR while maintaining an identical detection limit of viral nucleic acid suspended in water. Both the conventional and TWT methods estimated the total particle-to-infectious particle ratio for this strain of calicivirus at approximately 40 : 1. Conclusions: We believe that the TWT device with appropriate RT-PCR primers will decrease the detection limit for other calicivirus strains and RNA viruses in shellfish tissue extracts. Significance and Impact of the Study: We believe that the TWT approach is applicable to other situations where RT and/or PCR inhibitory materials are present or nucleic acid targets of bacteria or viruses are at low levels in extracts of food products or clinical specimens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALICIVIRUSES
KW - SHELLFISH
N1 - Accession Number: 7057526; Burkhardt, W 1 Blackstone, G.M 1 Skilling, D 2 Smith, A.W 2; Affiliation: 1: US Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL, USA, 2: Laboratory for Calicivirus Studies, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA; Source Info: Aug2002, Vol. 93 Issue 2, p235; Subject Term: CALICIVIRUSES; Subject Term: SHELLFISH; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2672.2002.01681.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ball, Robert
AU - Halsey, Neal
AU - Braun, M. Miles
AU - Moulton, Lawrence H.
AU - Gale, Arnold D.
AU - Rammohan, Kottil
AU - Wiznitzer, Max
AU - Johnson, Richard
AU - Salive, Marcel E.
T1 - Development of case definitions for acute encephalopathy, encephalitis, and multiple sclerosis reports to the Vaccine Adverse Event Reporting System
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2002/08//
VL - 55
IS - 8
M3 - Article
SP - 819
SN - 08954356
AB - The Vaccine Adverse Event Reporting System (VAERS), administered by the FDA and CDC, is the U.S. system for surveillance of vaccine adverse events (AE). Acute encephalopathy age <18 months (EO < 18), age ⩾18 months (EO ⩾ 18), encephalitis (EI), and multiple sclerosis (MS) after vaccination have been reported to VAERS, but reports often contain insufficient information to validate diagnoses. Standardized case definitions would enhance the utility of VAERS reports for AE surveillance. We developed practical case definitions for classification of VAERS reports, and three neurologists independently applied the definitions to reports submitted in 1993. Inter-observer agreement was assessed, and non-concordant classifications were reviewed in a follow-up conference call. Reports of EO < 18 (n = 8 ), EO ⩾ 18 (n = 20 ), EI (n = 15 ), and MS (n = 16 ) were classified as “definite” in 7% to 30% of the cases, while 26% to 51% of reports were thought to have insufficient information to make a classification. Agreement among reviewers was good to excellent, (kappa: 0.65 to 0.85) except for EO < 18 m for which it was marginal (kappa: 0.37). It is possible to develop reproducible case definitions for acute encephalopathy, encephalitis, and multiple sclerosis using a standardized approach. Application of standardized case definitions to VAERS reports documents the limited information in many reports, specifies data for supplemental collection, and indicates that VAERS reports should be cautiously interpreted. Development and application of case definitions for other adverse events reported after vaccination should enhance the value of vaccine safety databases. Published by Elsevier Science Inc. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Epidemiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - MULTIPLE sclerosis
KW - Adverse events
KW - Encephalitis
KW - Encephalopathy
KW - Immunization
KW - Multiple sclerosis
KW - Safety
KW - Surveillance
KW - Vaccine
N1 - Accession Number: 7899800; Ball, Robert 1; Email Address: ballr@cber.fda.gov Halsey, Neal 2 Braun, M. Miles 1 Moulton, Lawrence H. 2 Gale, Arnold D. 3 Rammohan, Kottil 4 Wiznitzer, Max 5 Johnson, Richard 6 Salive, Marcel E. 1; Affiliation: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD USA 2: Institute for Vaccine Safety, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD USA 3: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA USA 4: Department of Neurology, Ohio State University, Columbus, OH USA 5: Department of Neurology, Case Western Reserve University, Cleveland, OH USA 6: Department of Microbiology and Molecular Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD USA; Source Info: Aug2002, Vol. 55 Issue 8, p819; Subject Term: IMMUNIZATION; Subject Term: MULTIPLE sclerosis; Author-Supplied Keyword: Adverse events; Author-Supplied Keyword: Encephalitis; Author-Supplied Keyword: Encephalopathy; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Multiple sclerosis; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Surveillance; Author-Supplied Keyword: Vaccine; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Chaojie
AU - Imam, Syed Z.
AU - Ali, Syed F.
AU - Mayeux, Philip R.
T1 - Peroxynitrite and the regulation of Na+ ,K+ -ATPase activity by angiotensin II in the rat proximal tubule
JO - Nitric Oxide
JF - Nitric Oxide
Y1 - 2002/08//
VL - 7
IS - 1
M3 - Article
SP - 30
SN - 10898603
AB - NO reacts spontaneously with superoxide to produce the potent oxidant peroxynitrite. Studies were designed to examine the role of NO-derived oxidants and peroxynitrite on the regulation of Na+ ,K+ -ATPase activity by angiotensin II (ANG II) freshly isolated rat proximal tubules. At picomolar concentrations ANG II stimulates Na+ ,K+ -ATPase activity, but at nanomolar concentrations stimulation is lost. Superoxide dismutase (SOD) was used to examine the role of superoxide and deferoxamine (DFO) and uric acid (UA) were used to examine the role of peroxynitrite. SOD (200 U/mL, 5-min preincubation) restored the stimulatory effect of ANG II (1.31±0.08 -fold; n=4 ; P<0.05 compared to 10−7 M alone), suggesting a role for superoxide. DFO (100 μm , 5-min preincubation) also restored the stimulatory effect of ANG II (1.40±0.08 -fold; n=4 ; P<0.05 , compared to 10−7 M alone), as did UA (1.22±0.07 -fold; n=5 ; P<0.05 , compared to 10−7 M alone). The NO synthesis inhibitor, N-monomethyl-l-arginine (l-NMMA, 2 mM; 5-min preincubation), also unmasked a stimulatory effect of ANG II at 10−7 M (1.4±0.1 -fold; n=7 ; P<0.05 , compared to 10−7 M alone). The generation of peroxynitrite was further evidenced by the formation of 3-nitrotyrosine (3-NT). 3-NT increased 3.5-fold in tubules exposed to ANG II (10−7 M ) (0.0054±0.0019 3-NT/100 tyrosines for control and 0.019±0.0058 3-NT/100 tyrosines for ANG II, P<0.05 ; n=4 ) and l-NMMA prevented the increase. These data suggest that peroxynitrite signaling participates in the regulation of renal of Na+ ,K+ -ATPase activity. [Copyright &y& Elsevier]
AB - Copyright of Nitric Oxide is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphatase
KW - ANGIOTENSINS
KW - 3-Nitrotyrosine
KW - Deferoxamine
KW - Peroxynitrite
KW - Reactive nitrogen species
KW - Renal proximal tubule
KW - Superoxide dismutase
KW - Uric acid
N1 - Accession Number: 8511641; Zhang, Chaojie 1 Imam, Syed Z. 2 Ali, Syed F. 1,2 Mayeux, Philip R. 1; Email Address: mayeuxphilipr@uams.edu; Affiliation: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Mail Slot 611, 4301 W. Markham Street, Little Rock, AR 72205, USA 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA; Source Info: Aug2002, Vol. 7 Issue 1, p30; Subject Term: ADENOSINE triphosphatase; Subject Term: ANGIOTENSINS; Author-Supplied Keyword: 3-Nitrotyrosine; Author-Supplied Keyword: Deferoxamine; Author-Supplied Keyword: Peroxynitrite; Author-Supplied Keyword: Reactive nitrogen species; Author-Supplied Keyword: Renal proximal tubule; Author-Supplied Keyword: Superoxide dismutase; Author-Supplied Keyword: Uric acid; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van Kooij, Adriaan
AU - Middel, Jeena
AU - Jakab, Ferenc
AU - Elfferich, Peter
AU - Koedijk, Danny G.A.M.
AU - Feijlbrief, Matty
AU - Scheffer, Albert Jan
AU - Degener, John E.
AU - The, T. Hauw
AU - Scheek, Ruud M.
AU - Welling, Gjalt W.
AU - Welling-Wester, Sytske
T1 - High level expression and secretion of truncated forms of herpes simplex virus type 1 and type 2 glycoprotein D by the methylotrophic yeast Pichia pastoris
JO - Protein Expression & Purification
JF - Protein Expression & Purification
Y1 - 2002/08//
VL - 25
IS - 3
M3 - Article
SP - 400
SN - 10465928
AB - Herpes simplex virus type 1 and 2 (HSV-1 and -2) glycoproteins D (gD-1 and gD-2) play a role in the entry of the virus into the host cell. Availability of substantial amounts of these proteins, or large fragments thereof, will be needed to allow studies at the molecular level. We studied the potency of the Pichia pastoris yeast expression system to produce soluble forms of gD. The DNA sequences encoding the extracellular domains of gD {amino acids 1–314 (gD-1(1–314) ) and amino acids 1–254 (gD-1(1–254) ) of gD-1 and amino acids 1–314 of gD-2 (gD-2(1–314) )} were cloned into the P. pastoris yeast expression vector pPIC9. Two truncated forms of gD-1 were fitted with a His tail (designated as gD-1(1–314His) and gD-1(1–254His) ) to facilitate their purification. Large amounts of gD-1(1–314) and gD-1(1–314His) (280–300 mg/L induction medium) were produced. The yields of recombinant gD-1(1–254) and gD-1(1–254His) were lower: 20–36 mg/L, and the yield of the gD-2(1–314) fragment was much lower: 6 mg/L. SDS–PAGE analysis revealed multiple glycosylated species of the larger gD fragments, ranging in apparent molecular weight from 31 to 78 kDa. The smaller gD-1(1–254) fragment appeared as two bands with molecular weights of 33 and 31 kDa. All recombinant proteins produced by P. pastoris were recognized, as expected, by a panel of MAbs (A16, DL6, A18, DL11, HD1, ABDI, and AP7). In addition, we showed that gD-1(1–314) , gD-2(1–314) , and gD-1(1–254His) were able to interfere with binding of HSV to susceptible cells. These results indicate that the conformations of the recombinant proteins closely resemble those of native gD. [Copyright &y& Elsevier]
AB - Copyright of Protein Expression & Purification is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - GLYCOPROTEINS
KW - PICHIA pastoris
N1 - Accession Number: 8511756; van Kooij, Adriaan 1 Middel, Jeena 1 Jakab, Ferenc 2 Elfferich, Peter 1 Koedijk, Danny G.A.M. 1 Feijlbrief, Matty 1 Scheffer, Albert Jan 1 Degener, John E. 1 The, T. Hauw 3 Scheek, Ruud M. 4 Welling, Gjalt W. 1 Welling-Wester, Sytske 1; Email Address: s.welling-wester@med.rug.nl; Affiliation: 1: Department of Medical Microbiology, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands 2: County Institute of National Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary 3: Clinical Immunology, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands 4: Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands; Source Info: Aug2002, Vol. 25 Issue 3, p400; Subject Term: HERPES simplex virus; Subject Term: GLYCOPROTEINS; Subject Term: PICHIA pastoris; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ashman, J. J.
AU - Conviser, R.
AU - Pounds, M. B.
T1 - Associations between HIV-positive individuals' receipt of ancillary services and medical care receipt and retention.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002/08/02/Aug2002 Supplement 1
VL - 14
M3 - Article
SP - S109
EP - S118
PB - Routledge
SN - 09540121
AB - This study examines associations between HIV-positive individuals' receipt of ancillary services and their receipt of and retention in primary medical care. Ancillary care services examined include case management, mental health and substance abuse treatment/counseling, advocacy, respite and buddy/companion services, as well as food, housing, emergency financial assistance, and transportation. The selection criterion used was the receipt of care from January-June 1997 at selected facilities receiving funding under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act, a federally funded safety net programme in the USA. The receipt of each ancillary service was associated with the receipt of any primary medical care from a safety net provider. All ancillary services were more strongly associated with primary care receipt than with retention in care or the mean number of primary care visits per year. Mental health and substance abuse treatment/counselling, client advocacy, respite care and buddy/companion services all had significant associations with all primary medical care measures. This is the first time in one study that the primary medical and ancillary services received by all clients at safety net-funded providers from multiple cities and states have been examined. All types of safety net providers, from the largest medical centre to the smallest community-based organization, are represented in this study. The patterns seen here are similar to the findings from the other, geographically more restricted, studies reported on in this volume. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - PRIMARY care (Medicine)
KW - UNITED States
N1 - Accession Number: 7175424; Ashman, J. J. 1 Conviser, R. 1 Pounds, M. B. 1; Affiliation: 1: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, USA; Source Info: Aug2002 Supplement 1, Vol. 14, pS109; Subject Term: HIV-positive persons -- Medical care; Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/09540120220149993
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Conviser, R.
AU - Pounds, M. B.
T1 - The role of ancillary services in client-centred systems of care.
JO - AIDS Care
JF - AIDS Care
Y1 - 2002/08/02/Aug2002 Supplement 1
VL - 14
M3 - Article
SP - S119
EP - S131
PB - Routledge
SN - 09540121
AB - The studies in this issue reflect the operation of the Ryan White CARE Act's holistic model of health and support services for people living with HIV in the USA. Ancillary services available through the CARE Act are responsive to predisposing factors, enabling factors, and system characteristics that pose barriers to clients' receipt of primary medical care. That nearly all of the studies use cross-sectional rather than longitudinal data makes it difficult to draw causal inferences. Taken as a whole, however, the studies suggest that receipt of ancillary services such as case management, mental health and substance abuse treatment, transportation, and housing assistance is associated with primary care entry and retention among CARE Act clients. The studies and the literature out of which they arise suggest that there is a need to refine further our understanding of care systems so that we can refine the care systems themselves. Among the concepts proposed for the study of care systems are comprehensiveness, capacity, coordination, integration, cultural competence, and client-centredness. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons -- Medical care
KW - PRIMARY care (Medicine)
KW - UNITED States
N1 - Accession Number: 7175423; Conviser, R. 1 Pounds, M. B. 1; Affiliation: 1: HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, USA; Source Info: Aug2002 Supplement 1, Vol. 14, pS119; Subject Term: HIV-positive persons -- Medical care; Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/09540120220150018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Rong-Fu
AU - Beggs, Marjorie L.
AU - Robertson, Latriana H.
AU - Cerniglia, Carl E.
T1 - Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002/08/06/
VL - 213
IS - 2
M3 - Article
SP - 175
SN - 03781097
AB - An oligonucleotide-microarray method was developed for the detection of intestinal bacteria in fecal samples collected from human subjects. The 16S rDNA sequences of 20 predominant human intestinal bacterial species were used to design oligonucleotide probes. Three 40-mer oligonucleotides specific for each bacterial species (total 60 probes) were synthesized and applied to glass slides. Cyanine5 (CY5)-labeled 16S rDNAs were amplified by polymerase chain reaction (PCR) from human fecal samples or bacterial DNA using two universal primers and were hybridized to the oligo-microarray. The 20 intestinal bacterial species tested were Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides fragilis, Bacteroides distasonis, Clostridium clostridiiforme, Clostridium leptum, Fusobacterium prausnitzii, Peptostreptococcus productus, Ruminococcus obeum, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus albus, Bifidobacterium longum, Bifidobacterium adolescentis, Bifidobacterium infantis, Eubacterium biforme, Eubacterium aerofaciens, Lactobacillus acidophilus, Escherichia coli, and Enterococcus faecium. The two universal primers were able to amplify full size 16S rDNA from all of the 20 bacterial species tested. The hybridization results indicated that the oligo-microarray method developed in this study is a reliable method for the detection of predominant human intestinal bacteria in the fecal samples. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acid probes
KW - BACTERIAL diseases
KW - INTESTINES -- Infections
KW - 16S rDNAs amplification
KW - Human intestinal bacterium
KW - Oligonucleotide-microarray
KW - Polymerase chain reaction
N1 - Accession Number: 7859167; Wang, Rong-Fu 1; Email Address: rwang@nctr.fda.gov Beggs, Marjorie L. 2 Robertson, Latriana H. 1 Cerniglia, Carl E. 1; Affiliation: 1: Microbiology Division, National Center for Toxicological Research, US-FDA, Jefferson, AR 72079, USA 2: University of Arkansas for Medical Sciences, Department of Geriatrics, Core Microarray Facility, Little Rock, AR, USA; Source Info: Aug2002, Vol. 213 Issue 2, p175; Subject Term: NUCLEIC acid probes; Subject Term: BACTERIAL diseases; Subject Term: INTESTINES -- Infections; Author-Supplied Keyword: 16S rDNAs amplification; Author-Supplied Keyword: Human intestinal bacterium; Author-Supplied Keyword: Oligonucleotide-microarray; Author-Supplied Keyword: Polymerase chain reaction; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ma, Qiang
T1 - Induction and superinduction of 2,3,7,8 -tetrachlorodibenzo-p-dioxin-inducible poly(ADP-ribose) polymerase: Role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2002/08/15/
VL - 404
IS - 2
M3 - Article
SP - 309
SN - 00039861
AB - The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a novel poly(ADP-ribose) polymerase (TiPARP). In this study, the signaling pathway of the induction was analyzed. Induction of TiPARP by TCDD occurs in both hepa1c1c7 cells and C57 mouse liver. Induction is concentration and time dependent. Genetic analyses reveal that induction is abolished in aromatic hydrocarbon receptor (AhR)- or aromatic hydrocarbon receptor nuclear translocator (Arnt)-defective variants but restored upon reconstitution of the variant cells with cDNAs expressing functional AhR or Arnt. Moreover, induction is largely reduced in cells expressing a deletion mutant of AhR or Arnt lacking the transcription activation (TA) domain, thus implicating the TA activities of both AhR and Arnt in the induction. Inhibition of protein synthesis by cycloheximide enhances the induction of TiPARP in the presence of an AhR agonist. The superinduction is transcriptional and does not require pretreatment with TCDD. Finally, inhibition of the 26S proteasomes by MG132 superinduces TiPARP. These findings establish that induction of TiPARP by TCDD is mediated through an AhR and Arnt transcription activation-dependent signal transduction that is repressed by a labile factor through the ubiquitin–26S proteasome-mediated protein degradation. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACHLORODIBENZODIOXIN
KW - ADP-ribosylation
KW - Ah receptor
KW - Gene induction
KW - Superinduction
KW - TCDD
KW - TiPARP
N1 - Accession Number: 8509474; Ma, Qiang 1; Email Address: qam1@cdc.gov; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA; Source Info: Aug2002, Vol. 404 Issue 2, p309; Subject Term: TETRACHLORODIBENZODIOXIN; Subject Term: ADP-ribosylation; Author-Supplied Keyword: Ah receptor; Author-Supplied Keyword: Gene induction; Author-Supplied Keyword: Superinduction; Author-Supplied Keyword: TCDD; Author-Supplied Keyword: TiPARP; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, Anna A.
AU - Kisin, Elena
AU - Murray, Ashley
AU - Goldsmith, Travis
AU - Reynolds, Jeffrey S.
AU - Castranova, Vincent
AU - Frazer, David G.
AU - Kommineni, Choudari
T1 - Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets
JO - Toxicology
JF - Toxicology
Y1 - 2002/08/15/
VL - 177
IS - 2/3
M3 - Article
SP - 285
SN - 0300483X
AB - Metal working fluids (MWFs) have been widely known to cause asthma and neoplasia of the larynx, pancreas, rectum, skin and urinary bladder (Textbook of Clinical Occupational and Environmental Medicine (1994) 814; Am. J. Ind. Med. 32 (1997) 240; Am. J. Ind. Med. 33 (1997) 282; Am. J. Ind. Med. 22 (1994) 185). Other non-neoplastic respiratory effects in industrial workers attributed to MWFs include increased rates of cough, phlegm production, wheeze, chronic bronchitis and chest tightness (Eur. J. Resir. Dis. 63(118) (1982), 79; J. Occup. Med. 24 (1982) 473; Am. J. Ind. Med. 32 (1997) 450). The epidemic and endemic nature of immune mediated lung morbidity commonly known as hypersensitivity pneumonitis in workers from several different industries using MWFs has been well documented (J. Allergy clin. Immunol. 91 (1993) 311; Chest 108 (1995) 636; MMWR45 (1996) 606; Am. J. Ind. Med. 32 (1997) 423). We studied morphological/functional and antioxidant outcomes in lungs after inhalation exposure of vitamin E deficient mice to MWF (27 mg m−3 17 weeks, 5 days a week, 6 h a day). Mice were given vitamin E deficient (<10 IU kg−1 vitamin E) or basal diets (50 IU kg−1 vitamin E) for 35 weeks. Inhalation exposure to MWF started after 18 weeks on diet. Microscopic observation of lungs from mice given vitamin E deficient or sufficient diets revealed no inflammation or morphological alteration after exposure to MWF. Mice given vitamin E deficient diet exhibited a significant decrease (P<0.05) in breathing rate, peak inspiratory/expiratory flow, minute ventilation, and tidal volume compared with sufficient controls. However, no differences were found after exposure to MWF in pulmonary function, with the exception of tidal volume which also significantly decreased (P<0.05). Exposure to MWF reduced vitamin E, protein thiol and ascorbate level in lungs. Exposure to MWF in combination with a vitamin E deficient diet resulted in significantly enhanced accumulation of peroxidative products compared with vitamin E deficient controls. This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALWORKING lubricants
KW - PHYSIOLOGICAL oxidation
KW - RESPIRATION
KW - VITAMIN E
KW - MICE -- Physiology
KW - GSH
KW - Lung
KW - Metal working fluid
KW - Oxidative stress
KW - Vitamin E
N1 - Accession Number: 7851216; Shvedova, Anna A.; Email Address: ats1@cdc.gov Kisin, Elena 1 Murray, Ashley 1 Goldsmith, Travis 1 Reynolds, Jeffrey S. 1 Castranova, Vincent 1 Frazer, David G. 1 Kommineni, Choudari 1; Affiliation: 1: Health Effects Laboratory Division, Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mail Stop 2015 1095, Willowdale Road, Morgantown, WV 26505, USA; Source Info: Aug2002, Vol. 177 Issue 2/3, p285; Subject Term: METALWORKING lubricants; Subject Term: PHYSIOLOGICAL oxidation; Subject Term: RESPIRATION; Subject Term: VITAMIN E; Subject Term: MICE -- Physiology; Author-Supplied Keyword: GSH; Author-Supplied Keyword: Lung; Author-Supplied Keyword: Metal working fluid; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Vitamin E; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roach, John A.G.
AU - Mossoba, Magdi M.
AU - Yurawecz, M. Peter
AU - Kramer, John K.G.
T1 - Chromatographic separation and identification of conjugated linoleic acid isomers
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2002/08/16/
VL - 465
IS - 1/2
M3 - Article
SP - 207
SN - 00032670
AB - There are 56 possible geometric and positional isomers of conjugated octadecadienoic acids (18:2), better known as conjugated linoleic acid (CLA). Positive health benefits are ascribed to the consumption of the 9c,11t-18:2 and 10t,12c-18:2 isomers. The dietary significance of the other isomers is not known. Our understanding of the biological role of these acids relies on their proper identification and quantitation in complex biological extracts. Gas chromatography (GC) alone cannot completely separate the naturally occurring CLA isomers. The combination of silver ion high performance liquid chromatography (Ag+ HPLC) and GC offers the best separation of these isomers with complementary identification by GC–mass spectrometry (GC–MS) and GC–Fourier transform infrared (FTIR) analyses. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LINOLEIC acid
KW - NUCLEAR isomers
KW - Ag+ HPLC
KW - CLA
KW - Conjugated linoleic acid
KW - Dimethyloxazoline
KW - DMOX
KW - GC–FID
KW - GC–FTIR
KW - GC–MS
KW - Methyltriazolinedione
KW - MTAD
KW - Review
N1 - Accession Number: 7850885; Roach, John A.G. 1 Mossoba, Magdi M. 1; Email Address: magdi.mossoba@cfsan.fda.gov Yurawecz, M. Peter 1 Kramer, John K.G. 2; Affiliation: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 2: Food Research Program, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ont., Canada N1G 5C9; Source Info: Aug2002, Vol. 465 Issue 1/2, p207; Subject Term: LINOLEIC acid; Subject Term: NUCLEAR isomers; Author-Supplied Keyword: Ag+ HPLC; Author-Supplied Keyword: CLA; Author-Supplied Keyword: Conjugated linoleic acid; Author-Supplied Keyword: Dimethyloxazoline; Author-Supplied Keyword: DMOX; Author-Supplied Keyword: GC–FID; Author-Supplied Keyword: GC–FTIR; Author-Supplied Keyword: GC–MS; Author-Supplied Keyword: Methyltriazolinedione; Author-Supplied Keyword: MTAD; Author-Supplied Keyword: Review; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Varricchio, Frederick
T1 - Medication errors reported to the vaccine adverse event reporting system (VAERS)
JO - Vaccine
JF - Vaccine
Y1 - 2002/08/19/
VL - 20
IS - 25/26
M3 - Article
SP - 3049
SN - 0264410X
N1 - Accession Number: 7858022; Varricchio, Frederick 1; Email Address: varricchio@cber.fda.gov; Affiliation: 1: Office of Biostatistics and Epidemiology, Division of Epidemiology, Center for Biologics Evaluation and Review, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA; Source Info: Aug2002, Vol. 20 Issue 25/26, p3049; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yucesoy, Berran
AU - Sleijffers, Annemarie
AU - Kashon, Michael
AU - Garssen, Johan
AU - de Gruijl, Frank R.
AU - Boland, Greet J.
AU - van Hattum, Jan
AU - Simeonova, Petia P.
AU - Luster, Michael I.
AU - van Loveren, Henk
T1 - IL-1β gene polymorphisms influence hepatitis B vaccination
JO - Vaccine
JF - Vaccine
Y1 - 2002/08/19/
VL - 20
IS - 25/26
M3 - Article
SP - 3193
SN - 0264410X
AB - Considerable variability exists in the vaccine response to hepatitis B with 5–10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1β (IL-1β) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1β expression. Ninety-two healthy individuals who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule. At selected times, antibody titers and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1β polymorphisms using a polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titer and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1β (+3953) minor allelic variant. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-1
KW - GENETIC polymorphisms
KW - HEPATITIS B vaccine
KW - Hepatitis B vaccination
KW - IL-1β gene
KW - Polymorphism
N1 - Accession Number: 7858040; Yucesoy, Berran 1 Sleijffers, Annemarie 2,3 Kashon, Michael 1 Garssen, Johan 2 de Gruijl, Frank R. 4 Boland, Greet J. 5 van Hattum, Jan 5 Simeonova, Petia P. 1 Luster, Michael I. 1; Email Address: mluster@cdc.gov van Loveren, Henk 2; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508, USA 2: National Institute of Public Health and the Environment, Bilthoven, The Netherlands 3: Department of Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands 4: Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands 5: Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands; Source Info: Aug2002, Vol. 20 Issue 25/26, p3193; Subject Term: INTERLEUKIN-1; Subject Term: GENETIC polymorphisms; Subject Term: HEPATITIS B vaccine; Author-Supplied Keyword: Hepatitis B vaccination; Author-Supplied Keyword: IL-1β gene; Author-Supplied Keyword: Polymorphism; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jia, Yiping
AU - Alayash, Abdu I.
T1 - Stopped-flow fluorescence method for the detection of heme degradation products in solutions of chemically modified hemoglobins and peroxide
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2002/09//
VL - 308
IS - 1
M3 - Article
SP - 186
SN - 00032697
N1 - Accession Number: 8515242; Jia, Yiping 1 Alayash, Abdu I.; Email Address: alayash@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892, USA; Source Info: Sep2002, Vol. 308 Issue 1, p186; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sierra-Honigmann, Ana M.
AU - Krause, Philip R.
T1 - Live Oral Poliovirus Vaccines and Simian Cytomegalovirus
JO - Biologicals
JF - Biologicals
Y1 - 2002/09//
VL - 30
IS - 3
M3 - Article
SP - 167
SN - 10451056
AB - Live oral poliovirus vaccines (OPV) are often produced in primary Cercopithecus monkey kidney (CMK) cells. The kidneys of these monkeys are often latently infected with simian cytomegalovirus (SCMV), and CMK cultures are frequently contaminated with SCMV. We tested human, monkey and rabbit tissue culture systems, and found that MRC-5 cells are most sensitive for detection of SCMV. To address the question of whether OPV could be contaminated with infectious SCMV, we inoculated MRC-5 cells with neutralized OPV manufactured in the United States between 1972 and 1998. Infectious SCMV was not found in any of the vaccine lots tested. We also used the polymerase chain reaction (PCR) to search for SCMV DNA in live oral poliovirus vaccines; SCMV DNA sequences were found in several of the vaccine lots manufactured prior to 1992. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIO
KW - VACCINATION
KW - CYTOMEGALOVIRUSES
N1 - Accession Number: 8513533; Sierra-Honigmann, Ana M. 1 Krause, Philip R.; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A Rm 1C16 29 Lincoln Drive, Bethesda, MD 20892, U.S.A.; Source Info: Sep2002, Vol. 30 Issue 3, p167; Subject Term: POLIO; Subject Term: VACCINATION; Subject Term: CYTOMEGALOVIRUSES; Number of Pages: 8p; Document Type: Article
L3 - 10.1006/biol.2002.0325
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Harshinder
AU - Hnizdo, Vladimir
AU - Demchuk, Eugene
T1 - Probabilistic model for two dependent circular variables.
JO - Biometrika
JF - Biometrika
Y1 - 2002/09//
VL - 89
IS - 3
M3 - Article
SP - 719
EP - 723
SN - 00063444
AB - Motivated by problems in molecular biology and molecular physics, we propose a five‐parameter torus analogue of the bivariate normal distribution for modelling the distribution of two circular random variables. The conditional distributions of the proposed distribution are von Mises. The marginal distributions are symmetric around their means and are either unimodal or bimodal. The type of shape depends on the configuration of parameters, and we derive the conditions that ensure a specific shape. The utility of the proposed distribution is illustrated by the modelling of angular variables in a short linear peptide. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR biology
KW - GAUSSIAN distribution
KW - RANDOM variables
KW - MARGINAL distributions
KW - PEPTIDES
KW - Bivariate circular data
KW - Circular random variable
KW - Directional data
KW - Torus
KW - Von Mises distribution
N1 - Accession Number: 44401203; Singh, Harshinder 1; Email Address: hsingh@stat.wvu.edu Hnizdo, Vladimir 2; Email Address: vhnizdo@cdc.gov Demchuk, Eugene 2; Email Address: eed5@cdc.gov; Affiliation: 1: Department of Statistics, West Virginia University, Morgan town, West Virginia 26506-6330, U.S.A. 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, U.S.A.; Source Info: Sep2002, Vol. 89 Issue 3, p719; Subject Term: MOLECULAR biology; Subject Term: GAUSSIAN distribution; Subject Term: RANDOM variables; Subject Term: MARGINAL distributions; Subject Term: PEPTIDES; Author-Supplied Keyword: Bivariate circular data; Author-Supplied Keyword: Circular random variable; Author-Supplied Keyword: Directional data; Author-Supplied Keyword: Torus; Author-Supplied Keyword: Von Mises distribution; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lazarus, E
T1 - Adoptive immunotherapy, the Food and Drug Administration and you: a regulatory approach to donor lymphocytes.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 2002/09//
VL - 4
IS - 5
M3 - Article
SP - 449
EP - 449
PB - Taylor & Francis Ltd
SN - 14653249
AB - Discusses the process of implementing a regulatory approach to donor lymphocytes for infusion. Considerations for implementation; Definition of homologous use; Details of the U.S. Food and Drug Administration's consideration whether some or all uses of donor lymphocytes for their immunological defects in the treatment of disease should be considered homologous use.
KW - THERAPEUTICS
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - INFUSION therapy
KW - IMMUNOLOGY
N1 - Accession Number: 10909698; Lazarus, E 1; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Source Info: Sep2002, Vol. 4 Issue 5, p449; Subject Term: THERAPEUTICS; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: INFUSION therapy; Subject Term: IMMUNOLOGY; Number of Pages: 1p; Document Type: Article
L3 - 10.1080/146532402320776152
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keane-Moore, M
T1 - Adoptive immunotherapy — the Food and Drug Administration and you: a regulatory framework for manipulated cellular products.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 2002/09//
VL - 4
IS - 5
M3 - Article
SP - 451
EP - 453
PB - Taylor & Francis Ltd
SN - 14653249
AB - Discusses the new regulatory framework proposed by the U.S. Food and Drug Administration for human cellular and tissue-based products, including hematopoietic stem cells. Details of a comprehensive plan for regulating human cells, tissues, and cellular and tissue-based products (HCT/P); Criteria for the regulation of the HCT/P under Section 361 of the Public Health Service Act.
KW - HEMATOPOIETIC stem cells
KW - CELLS
KW - STEM cells
KW - PUBLIC health
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 10909685; Keane-Moore, M 1; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Source Info: Sep2002, Vol. 4 Issue 5, p451; Subject Term: HEMATOPOIETIC stem cells; Subject Term: CELLS; Subject Term: STEM cells; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/146532402320776161
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Badano, Aldo
AU - Flynn, Michael J.
AU - Kanicki, Jerzy
T1 - Accurate small-spot luminance measurements
JO - Displays
JF - Displays
Y1 - 2002/09//
VL - 23
IS - 4
M3 - Article
SP - 177
SN - 01419382
AB - It has been reported recently that conventional methods for measuring the contrast ratio of display devices using small dark spots can provide inaccurate data if flare in lenses and other optical components is not taken into account. In this paper, we describe a method for reliable measurements of small-spot contrast ratios based on a collimated probe specially designed and constructed to minimize the signal contamination to less than 10−4 of the bright field. We show that this method can be used to measure the luminance of small circular targets to characterize the veiling glare of cathode-ray tubes. We compare ring response functions obtained for monochrome and color monitors and explain the differences between them in terms of the relative weight of the electron back-scattering and optical components of veiling glare. The method is also useful for characterizing crosstalk in large size active-matrix liquid crystal displays, by measuring luminance changes in small square targets due to variations in the background intensity. Our results suggest that even for medium size arrays, a difference of 1% can be found in the luminance of the small target due to changes in the background luminance. [Copyright &y& Elsevier]
AB - Copyright of Displays is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLLIMATORS (Optical instrument)
KW - CROSSTALK
KW - Display contrast
KW - Display measurements
KW - Electronic crosstalk
KW - Veiling glare
N1 - Accession Number: 7907809; Badano, Aldo 1,2 Flynn, Michael J. 3,4 Kanicki, Jerzy 2; Affiliation: 1: US FDA, Center for Devices and Radiological Health, 12720 Twinbrook Parkway, Mail Stop HFZ-142, Room 167, Rockville, MD 20857, USA 2: Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA 3: Department of Diagnostic Radiology, Henry Ford Health System, Detroit, MI 48202, USA 4: Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Source Info: Sep2002, Vol. 23 Issue 4, p177; Subject Term: COLLIMATORS (Optical instrument); Subject Term: CROSSTALK; Author-Supplied Keyword: Display contrast; Author-Supplied Keyword: Display measurements; Author-Supplied Keyword: Electronic crosstalk; Author-Supplied Keyword: Veiling glare; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takamatsu, Narushi
AU - Welage, Lynda S.
AU - Hayashi, Yayoi
AU - Yamamoto, Ryuzo
AU - Barnett, Jeffrey L.
AU - Shah, Vinod P.
AU - Lesko, Lawrence J.
AU - Ramachandran, Chandrasekharan
AU - Amidon, Gordon L.
T1 - Corrigendum to “Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility” [Eur. J. Pharm. Biopharm. 53 (2002) 37–47]
JO - European Journal of Pharmaceutics & Biopharmaceutics
JF - European Journal of Pharmaceutics & Biopharmaceutics
Y1 - 2002/09//
VL - 54
IS - 2
M3 - Correction notice
SP - 255
SN - 09396411
N1 - Accession Number: 7862993; Takamatsu, Narushi 1 Welage, Lynda S. 2 Hayashi, Yayoi 3 Yamamoto, Ryuzo 4 Barnett, Jeffrey L. 5 Shah, Vinod P. 6 Lesko, Lawrence J. 6 Ramachandran, Chandrasekharan 2 Amidon, Gordon L. 2; Email Address: glamidon@umich.edu; Affiliation: 1: Yamanouchi Pharmaceutical Co. Ltd., Shizuoka, Japan 2: College of Pharmacy, The University of Michigan, Ann Arbor, MI, USA 3: Nagoya City University, Aichi, Japan 4: Ono Phamaceutical Co. Ltd., Osaka, Japan 5: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA 6: Food and Drug Administration, Rockville, MD, USA; Source Info: Sep2002, Vol. 54 Issue 2, p255; Number of Pages: 1p; Document Type: Correction notice
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tauxe, Robert V.
T1 - Surveillance and investigation of foodborne diseases; roles for public health in meeting objectives for food safety
JO - Food Control
JF - Food Control
Y1 - 2002/09//
VL - 13
IS - 6/7
M3 - Article
SP - 363
SN - 09567135
AB - Each year, an estimated 76,000,000 persons experience a foodborne infection in the United States. Preventing foodborne infections requires sustained efforts along the entire chain of production. Public health surveillance drives a number of disease prevention programs, including tuberculosis control, polio eradication, and foodborne disease prevention. CDC has launched several new approaches to foodborne disease surveillance, including FoodNet, PulseNet, and the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS). The capacity of public health surveillance in the United States to detect and investigate dispersed foodborne disease outbreaks has been improving dramatically in recent years. Investigation of such outbreaks can yield important insights in how to improve prevention strategies. Many foodborne diseases are preventable, though prevention will require a number of control efforts along the chain from production to consumption. Although progress has been made to date as a result of recent improvements in food safety, further prevention efforts are required in the United States if we are to reach the public health objectives set for 2010. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOODBORNE diseases
KW - FOOD -- Safety measures
KW - UNITED States
KW - Antimicrobial resistance
KW - Foodborne disease outbreak
KW - Foodborne diseases
KW - Public health surveillance
N1 - Accession Number: 7857900; Tauxe, Robert V. 1; Email Address: rvt1@cdc.gov; Affiliation: 1: National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, GA, USA; Source Info: Sep2002, Vol. 13 Issue 6/7, p363; Subject Term: FOODBORNE diseases; Subject Term: FOOD -- Safety measures; Subject Term: UNITED States; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Foodborne disease outbreak; Author-Supplied Keyword: Foodborne diseases; Author-Supplied Keyword: Public health surveillance; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Jerome P.
AU - Bird, Aaron J.
T1 - Relationship of sampling efficiency for manikin-mounted personal samplers to efficiency measurements made independent of manikin
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2002/09//
VL - 33
IS - 9
M3 - Article
SP - 1235
SN - 00218502
AB - The goal of this study was to determine if measurement of the airflow approaching manikin-mounted personal samplers can be used to predict their sampling efficiency using efficiency measurements made independently of the manikin. The first part of the work involved the determination of the velocity and direction of airflow at specific locations (where personal samplers would be located) around a human-like manikin by using laser-Doppler velocimetry (LDV) at two wind speeds and three orientations of the manikin with respect to the wind. Sampling-efficiency measurements for two personal samplers, the IOM (SKC, Inc., Eighty-Four, PA) and GSP (Strohlein GmbH and Co., Kaarst, Germany) for a 70 μm (mass median diameter) aerosol were made both independently of the manikin for a range of wind speeds and directions and while mounted on the manikin for the wind speeds and directions studied by LDV. The efficiency measurements made independently of the manikin were adjusted by using the local-manikin concentration experienced by the sampler to calculate an approximated efficiency for manikin-mounted personal samplers that experienced a similar wind speed and direction. The approximated efficiency agreed with the measured efficiency of the manikin-mounted samplers when the manikin faced the wind or was at 90° to the wind. Some assumptions were required to obtain agreement when the manikin was at 180° to the wind probably due to the turbulent nature of the flow with the manikin at this angle to the wind. This technique may be useful in simplifying testing procedures and in developing performance criteria for inhalable dust samplers since clearly defined test conditions can be specified. [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Process)
KW - LASER Doppler velocimeter
KW - WIND speed
KW - Airflow behavior
KW - Manikin-mounted samplers
KW - Personal samplers
N1 - Accession Number: 7867111; Smith, Jerome P. 1; Email Address: jps3@cdc.gov Bird, Aaron J. 2,3; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505, USA 3: Industrial and Management Systems Engineering Department, P.O. Box 6107, West Virginia University, Morgantown, WV 26506, USA; Source Info: Sep2002, Vol. 33 Issue 9, p1235; Subject Term: SAMPLING (Process); Subject Term: LASER Doppler velocimeter; Subject Term: WIND speed; Author-Supplied Keyword: Airflow behavior; Author-Supplied Keyword: Manikin-mounted samplers; Author-Supplied Keyword: Personal samplers; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scott, Michelle A.
AU - Snowden, Lonnie
AU - Libby, Anne M.
T1 - From Mental Health to Juvenile Justice: What Factors Predict This Transition?
JO - Journal of Child & Family Studies
JF - Journal of Child & Family Studies
Y1 - 2002/09//
VL - 11
IS - 3
M3 - Article
SP - 299
EP - 311
PB - Springer Science & Business Media B.V.
SN - 10621024
AB - We identify youth who are at risk for a critical transition from mental health to juvenile justice. A statewide longitudinal sample of Medicaid-eligible youth (aged 10–17) in the public mental health system (n = 5,455), during approximately one fiscal year (July 1, 1994–August 30, 1995), was used to determine the risk factors for, and timing of, a subsequent juvenile justice detention or commitment during the three subsequent fiscal years (1994–1997). Logistic regression and Cox Proportional Hazards modeling were used. Risk factors for juvenile justice detention or commitment included being: male, black or Hispanic, in junior high school, involuntarily admitted to mental health, having a DSM-IV diagnosis of conduct disorder, alcohol problems, a constellation of risk behavior, and receiving prior mental health services. Factors that accelerate the timing of detention or commitment in the juvenile justice system after a mental health visit included most of the general risk factors except risk behavior and involuntary admission were no longer significant and having a DSM-IV nonalcohol drug use diagnosis, antisocial behavior, and school problems became significant. Our study helps to identify youth who are at risk for multiple system use so that they may be provided appropriate services to prevent multiple system use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Child & Family Studies is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS
KW - MENTAL health
KW - LOGISTIC regression analysis
KW - JUVENILE justice administration
KW - PUBLIC health
KW - HEALTH
KW - adolescents
KW - juvenile justice
KW - mental health
KW - multiple system use
KW - multiple system use.
KW - risk factors
N1 - Accession Number: 7554173; Scott, Michelle A. 1; Email Address: scottm@child.psych.columbia.edu. Snowden, Lonnie 2 Libby, Anne M. 3; Affiliation: 1: Research Fellow, Division of Child and Adolescent Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY. 2: Director, Center for Mental Health Services Research, University of California, Berkeley, Berkeley, CA. 3: Professor, Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO.; Source Info: Sep2002, Vol. 11 Issue 3, p299; Subject Term: TEENAGERS; Subject Term: MENTAL health; Subject Term: LOGISTIC regression analysis; Subject Term: JUVENILE justice administration; Subject Term: PUBLIC health; Subject Term: HEALTH; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: juvenile justice; Author-Supplied Keyword: mental health; Author-Supplied Keyword: multiple system use; Author-Supplied Keyword: multiple system use.; Author-Supplied Keyword: risk factors; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bond Huie, Stephanie A.
AU - Hummer, Robert A.
AU - Rogers, Richard G.
T1 - Individual and Contextual Risks of Death among Race and Ethnic Groups in the United States.
JO - Journal of Health & Social Behavior
JF - Journal of Health & Social Behavior
Y1 - 2002/09//
VL - 43
IS - 3
M3 - Article
SP - 359
EP - 381
SN - 00221465
AB - An emerging area of social science research focuses on individual-level and contextual-level determinants of black-white adult mortality differentials in the United States. However, no research on adult mortality differentials has distinguished multiple Hispanic subgroups and explored the role of nativity at both the individual and contextual levels for small geographic areas. Using the 1986-1997 National Health Interview Survey-National Death Index linked file, we examine the effects of individual and contextual factors on black-white and multiple Hispanic subgroup (Mexican Americans, Puerto Ricans, and "other" Hispanic) differentials in adult mortality. In addition, we use a new, innovative geographic area--the very small area--as our contextual unit of analysis. We find that excess mortality risks for all race-ethnic groups considered are associated with not only individual characteristics, but also neighborhood characteristics. In addition, percent foreign born in a neighborhood is protective of Hispanic subgroup mortality for Puerto Rican, Mexican American, and "other" Hispanic adults in the 45-64 age category. These findings indicate a need for future research to examine more thoroughly the pathways through which neighborhood factors affect multiple Hispanic subgroup mortality and the role of nativity as a protective factor for older adult Hispanic mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health & Social Behavior is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL sciences -- United States
KW - MORTALITY -- Statistics
KW - ETHNOLOGY -- United States
KW - SOCIAL science research
KW - MORTALITY
KW - RACIAL differences
KW - UNITED States
N1 - Accession Number: 8662845; Bond Huie, Stephanie A. 1; Email Address: shuie@ahrq.gov Hummer, Robert A. 2 Rogers, Richard G. 3; Affiliation: 1: The Agency for Healthcare Research and Quality 2: The University of Texas-Austin 3: The University of Colorado-Boulder; Source Info: Sep2002, Vol. 43 Issue 3, p359; Subject Term: SOCIAL sciences -- United States; Subject Term: MORTALITY -- Statistics; Subject Term: ETHNOLOGY -- United States; Subject Term: SOCIAL science research; Subject Term: MORTALITY; Subject Term: RACIAL differences; Subject Term: UNITED States; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 23p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campbell, Grant L
AU - Marfin, Anthony A
AU - Lanciotti, Robert S
AU - Gubler, Duane J
T1 - West Nile virus
JO - Lancet Infectious Diseases
JF - Lancet Infectious Diseases
Y1 - 2002/09//
VL - 2
IS - 9
M3 - Article
SP - 519
SN - 14733099
AB - West Nile (WN) virus is a mosquito-borne flavivirus and human, equine, and avian neuropathogen. The virus is indigenous to Africa, Asia, Europe, and Australia, and has recently caused large epidemics in Romania, Russia, and Israel. Birds are the natural reservoir (amplifying) hosts, and WN virus is maintained in nature in a mosquito-bird-mosquito transmission cycle primarily involving Culex sp mosquitoes. WN virus was recently introduced to North America, where it was first detected in 1999 during an epidemic of meningoencephalitis in New York City. During 1999–2002, the virus extended its range throughout much of the eastern parts of the USA, and its range within the western hemisphere is expected to continue to expand. During 1999–2001, 142 cases of neuroinvasive WN viral disease of the central nervous system (including 18 fatalities), and seven cases of uncomplicated WN fever were reported in the USA. Most human WN viral infections are subclinical but clinical infections can range in severity from uncomplicated WN fever to fatal meningoencephalitis; the incidence of severe neuroinvasive disease and death increase with age. Serology remains the mainstay of laboratory diagnosis. No WN virus-specific treatment or vaccine is available. Prevention depends on organised, sustained vector mosquito control, and public education. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lancet Infectious Diseases is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEST Nile fever
KW - EPIDEMIC encephalitis
N1 - Accession Number: 7863945; Campbell, Grant L; Email Address: glcampbell@cdc.gov Marfin, Anthony A 1 Lanciotti, Robert S 1 Gubler, Duane J 1; Affiliation: 1: GLC, AAM, RSL, and DJG are with the Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Public Health Service, Department of Health and Human Services, Fort Collins, Colorado, USA; Source Info: Sep2002, Vol. 2 Issue 9, p519; Subject Term: WEST Nile fever; Subject Term: EPIDEMIC encephalitis; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ishibe, Naoko
AU - Prieto, DaRue
AU - Hosack, Douglas A.
AU - Lempicki, Richard A.
AU - Goldin, Lynn R.
AU - Raffeld, Mark
AU - Marti, Gerald E.
AU - Caporaso, Neil E.
T1 - Telomere length and heavy-chain mutation status in familial chronic lymphocytic leukemia
JO - Leukemia Research
JF - Leukemia Research
Y1 - 2002/09//
VL - 26
IS - 9
M3 - Article
SP - 791
SN - 01452126
AB - We examined whether telomere lengths of peripheral blood mononuclear cells are associated with immunoglobulin gene usage in 21 familial chronic lymphocytic leukemia (CLL) patients. Subjects with unmutated V genes tended to have shorter telomeres than those with somatic mutations, especially after adjusting for age. Unlike VH mutation status, telomere length was not predictive for survival. Our results suggest that telomere length is associated with VH gene mutation status and provides further evidence that the biological basis of familial B-CLL is similar to that of sporadic patients. [Copyright &y& Elsevier]
AB - Copyright of Leukemia Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - TELOMERES
KW - Familial CLL
KW - Telomere length
KW - VH mutation
N1 - Accession Number: 7844041; Ishibe, Naoko 1; Email Address: ishiben@exchange.nih.gov Prieto, DaRue 2 Hosack, Douglas A. 2 Lempicki, Richard A. 2 Goldin, Lynn R. 1 Raffeld, Mark 3 Marti, Gerald E. 4 Caporaso, Neil E. 1; Affiliation: 1: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7236, Rockville, MD 20892, USA 2: SAIC-Frederick, Clinical Services Program, National Institutes of Health, Frederick, MD 21702, USA 3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 4: Flow and Image Cytometry Section, Division of Cell and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, MD 20852, USA; Source Info: Sep2002, Vol. 26 Issue 9, p791; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: TELOMERES; Author-Supplied Keyword: Familial CLL; Author-Supplied Keyword: Telomere length; Author-Supplied Keyword: VH mutation; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schmidt, G.R.
AU - Yemm, R.S.
AU - Childs, K.D.
AU - O'Callaghan, J.P.
AU - Hossner, K.L.
T1 - Verification of different glial fibrillary acidic protein (GFAP) analyses as accurate detectors of central nervous system tissue in advanced meat recovery (AMR) products
JO - Meat Science
JF - Meat Science
Y1 - 2002/09//
VL - 62
IS - 1
M3 - Article
SP - 79
SN - 03091740
AB - A glial fibrillary acidic protein (GFAP) fluorescent enzyme linked immunosorbant assay (ELISA) was compared with an ELISA test kit for GFAP to determine the level of central nervous system (CNS) tissue in advanced meat recovery (AMR) products. The test kit results were highly correlated (r=0.975) with the fluorescent ELISA. Meat cuts and AMR were analyzed on site at 14 meat plants utilizing the test kits. In seven of the plants all AMR samples had less than 1 ng GFAP. Seven of the plants had greater than 1 ng GFAP in AMR samples. Development of proper process controls to eliminate inclusion of spinal cord in AMR materials should bring all values to less than 1 ng GFAP, a level slightly above background. [Copyright &y& Elsevier]
AB - Copyright of Meat Science is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - CENTRAL nervous system
KW - MEAT
KW - Central nervous system tissue in advanced meat recovery product
N1 - Accession Number: 7820584; Schmidt, G.R. 1; Email Address: gschmidt@ceres.agsci.colostate.edu Yemm, R.S. 1 Childs, K.D. 1 O'Callaghan, J.P. 2 Hossner, K.L. 1; Affiliation: 1: Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523-1171, USA 2: Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Sep2002, Vol. 62 Issue 1, p79; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: CENTRAL nervous system; Subject Term: MEAT; Author-Supplied Keyword: Central nervous system tissue in advanced meat recovery product; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Herman, Bruce A.
AU - Harris, Gerald R.
T1 - Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
Y1 - 2002/09//
VL - 28
IS - 9
M3 - Article
SP - 1217
SN - 03015629
AB - A new diagnostic ultrasound (US) technique, sometimes called radiation force imaging, produces and detects motion in solid tissue or acoustic streaming in fluids via a high-intensity beam. Current models for estimating temperature rise during US exposure calculate the steady-state rise, using time-averaged acoustic output, as the worst case for safety consideration. Although valid for very short pulses, this analysis might not correspond to a worst-case scenario for the longer pulses or pulse bursts, up to hundreds of ms, used by this newer method. Models are presented to calculate the transient temperature rise from these pulse bursts for both the bone at focus and soft tissue situation. It is shown, based on accepted time-temperature dose criteria, that, for the bone at focus case and pulse lengths and intensities utilized by these methods, temperature may increase to levels that raise safety concerns. Also, regulatory aspects of this modality are analyzed in terms of the current FDA acoustic output limits for diagnostic US devices. (E-mail: bah@cdrh.fda.gov) [Copyright &y& Elsevier]
AB - Copyright of Ultrasound in Medicine & Biology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSTIC ultrasonic imaging
KW - ULTRASONIC imaging
KW - TEMPERATURE measurements
KW - Acoustic output
KW - Biomedical ultrasound
KW - Diagnostic ultrasound
KW - Exposure regulation
KW - Temperature rise
KW - Ultrasonic heating
N1 - Accession Number: 7908034; Herman, Bruce A. 1; Email Address: bah@cdrh.fda.gov Harris, Gerald R. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA; Source Info: Sep2002, Vol. 28 Issue 9, p1217; Subject Term: DIAGNOSTIC ultrasonic imaging; Subject Term: ULTRASONIC imaging; Subject Term: TEMPERATURE measurements; Author-Supplied Keyword: Acoustic output; Author-Supplied Keyword: Biomedical ultrasound; Author-Supplied Keyword: Diagnostic ultrasound; Author-Supplied Keyword: Exposure regulation; Author-Supplied Keyword: Temperature rise; Author-Supplied Keyword: Ultrasonic heating; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feng, Z.-H.
AU - Wang, T.-G.
AU - Li, D.-D.
AU - Fung, P.
AU - Wilson, B.C.
AU - Liu, B.
AU - Ali, Syed F.
AU - Langenbach, R.
AU - Hong, J.-S.
T1 - Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2002/09/06/
VL - 329
IS - 3
M3 - Article
SP - 354
SN - 03043940
AB - Cyclooxygenases (COX), key enzymes in prostanoid biosynthesis, may represent important therapeutic targets in various neurodegenerative diseases. In the present study, we explored the role of COX in Parkinson''s disease (PD) by using 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine (MPTP) as a tool to create a rodent Parkinsonian model. MPTP (20 mg/kg, subcutaneously) was injected daily into COX-1- and COX-2-deficient mice and wild-type (WT) controls for five consecutive days. Immunocytochemical analysis of tissues collected 7 days after the final MPTP treatment showed that MPTP significantly decreased the number of tyrosine hydroxylase-immunoreactive (TH-ir) neurons in the substantia nigra pars compacta (SNc) of WT (40% decrease) and COX-1−/− (45% decrease) mutants. However, a much smaller loss of TH-ir neurons in COX-2−/− mutants (20% decrease) was observed. Furthermore, electrochemical analysis revealed a more than 70% decrease in the levels of dopamine and its metabolites (3,4-dihydroxyphenylacetic acid and homovanillic acid) in the striatum of the WT control COX-1−/− and COX-2−/− mutant mice. These results indicate that loss of COX-2 activity reduces MPTP-induced damage to the dopaminergic neurons of the SNc, but does not alter the levels of dopamine and its metabolites in the striatum. Interestingly, MPTP caused the same degree of loss of dopaminergic neurons in both COX-2+/− and COX-2−/− mice (20% loss). The results of this study indicate an important role of COX-2 in MPTP-induced neuronal degeneration and suggest the possibility that manipulation of the COX-2 could be an important target for therapeutic interventions in PD. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARKINSON'S disease
KW - ENZYMES
KW - RODENTS
KW - 1-Methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine
KW - Cyclooxygenase-2
KW - Dopamine
KW - Parkinson's disease
KW - Tyrosine hydroxylase
N1 - Accession Number: 7862399; Feng, Z.-H. 1 Wang, T.-G. 2 Li, D.-D. 1 Fung, P. 1 Wilson, B.C. 2 Liu, B. 2 Ali, Syed F. 3 Langenbach, R. 4 Hong, J.-S. 2; Email Address: hong3@niehe.nih.gov; Affiliation: 1: University Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong 2: Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA 4: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA; Source Info: Sep2002, Vol. 329 Issue 3, p354; Subject Term: PARKINSON'S disease; Subject Term: ENZYMES; Subject Term: RODENTS; Author-Supplied Keyword: 1-Methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine; Author-Supplied Keyword: Cyclooxygenase-2; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Parkinson's disease; Author-Supplied Keyword: Tyrosine hydroxylase; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nayak, Rajesh
AU - Khan, Saeed A.
AU - Watson, Robert H.
AU - Cerniglia, Carl E.
T1 - Influence of growth media on vancomycin resistance of Enterococcus isolates and correlation with resistance gene determinants
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2002/09/10/
VL - 214
IS - 2
M3 - Article
SP - 159
SN - 03781097
AB - The effect of Mueller–Hinton (MH), MH+blood or brain heart infusion medium (agar or broth) on 13 Enterococcus isolates was determined, when testing their antibiotic susceptibility. Disk diffusion and Vitek methods were used to determine vancomycin resistance, while broth dilution and E-test methods were used to measure the minimum inhibitory concentration. The data were correlated with the presence of vancomycin resistance genes. A definite correlation pattern could not be established between the presence of van genes and vancomycin resistance in any plating medium, when tested by the disk diffusion assay. The broth dilution, irrespective of the plating medium, and Vitek methods were more reliable than the E-test method in testing isolates with vanA or vanB genes. However, for vanC2/C3 genotypes, the E-test method, irrespective of the plating medium, tested better than the broth dilution assay. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VANCOMYCIN
KW - ENTEROCOCCUS
KW - DRUG resistance
KW - Antibiotic susceptibility testing method
KW - Plating medium
KW - van gene
KW - Vancomycin-resistant enterococcus
N1 - Accession Number: 7881928; Nayak, Rajesh 1 Khan, Saeed A. 1; Email Address: skhan@nctr.fda.gov Watson, Robert H. 2 Cerniglia, Carl E. 1; Affiliation: 1: US Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA 2: Brooks Air Force Base, San Antonio, TX 78235, USA; Source Info: Sep2002, Vol. 214 Issue 2, p159; Subject Term: VANCOMYCIN; Subject Term: ENTEROCOCCUS; Subject Term: DRUG resistance; Author-Supplied Keyword: Antibiotic susceptibility testing method; Author-Supplied Keyword: Plating medium; Author-Supplied Keyword: van gene; Author-Supplied Keyword: Vancomycin-resistant enterococcus; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schmued, Larry C.
T1 - The progression of neuronal, myelin, astrocytic, and immunological changes in the rat brain following exposure to aurothioglucose
JO - Brain Research
JF - Brain Research
Y1 - 2002/09/13/
VL - 949
IS - 1/2
M3 - Article
SP - 171
SN - 00068993
AB - Aurothioglucose (ATG) is presently employed both by clinicians in the treatment of advanced rheumatoid arthritis and by neuroscience researchers to generate lesions around the circumventricular organs (CVOs) of rodent brains, resulting in obese animals. Although the existence of such lesions is well documented, there is relatively little information concerning the changes over time of the different cell types in the regions surrounding the CVOs. To address this question, specific markers allowing identification of four distinct cellular populations were used to characterize respective changes over time. Generally, regions adjacent to the CVOs were more vulnerable than the CVOs themselves, while more caudal structures were more frequently lesioned than more anterior CVO regions. Vascular and glial cells appeared to be the initial targets of ATG, while neuronal cell death occurred subsequent to the inflammatory response. The results of this study help resolve the mechanism of ATG toxicity as reflected by a cascade of pathologies that is consistent with disparate cell types exhibiting specific changes at specific times. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CIRCUMVENTRICULAR organs
KW - GOLD -- Therapeutic use
KW - NERVOUS system -- Diseases
KW - Blood–brain barrier
KW - Circumventricular organ
KW - Gold therapeutics
KW - Gold thioglucose
KW - Neuropathology
N1 - Accession Number: 7870024; Schmued, Larry C. 1; Email Address: lschmued@nctr.fda.gov; Affiliation: 1: Department of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA; Source Info: Sep2002, Vol. 949 Issue 1/2, p171; Subject Term: CIRCUMVENTRICULAR organs; Subject Term: GOLD -- Therapeutic use; Subject Term: NERVOUS system -- Diseases; Author-Supplied Keyword: Blood–brain barrier; Author-Supplied Keyword: Circumventricular organ; Author-Supplied Keyword: Gold therapeutics; Author-Supplied Keyword: Gold thioglucose; Author-Supplied Keyword: Neuropathology; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamminga, Carol A.
AU - Nemeroff, Charles B.
AU - Blakely, Randy D.
AU - Brady, Linda
AU - Carter, Cameron S.
AU - Davis, Kenneth L.
AU - Dingledine, Raymond
AU - Gorman, Jack M.
AU - Grigoriadis, Dimitri E.
AU - Henderson, David C.
AU - B. Innis, Robert
AU - Killen, John
AU - Laughren, Thomas P.
AU - McDonald, William M.
AU - M. Murphy Jr, Greer
AU - Paul, Steven M.
AU - Rudorfer, Matthew V.
AU - Sausville, Edward
AU - Schatzberg, Alan F.
AU - Scolnick, Edward M.
T1 - Developing novel treatments for mood disorders: accelerating discovery
JO - Biological Psychiatry
JF - Biological Psychiatry
Y1 - 2002/09/15/
VL - 52
IS - 6
M3 - Article
SP - 589
SN - 00063223
AB - This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad strokes, current pharmacologic treatments, and new directions in the field. Thereafter the topics focus on specific research initiatives that could advance the current therapeutics for mood disorders including new basic and clinical research in vivo human imaging procedures, somatic therapeutics, and the vast new area of pharmacogenetics. New scientific and technical opportunities exist today based on advances in basic neuroscience, opportunities in clinical testing, industry interest in advancing central nervous system therapeutics, and on active consumer advocacy groups. The question of how to bring all of these positive forces together to accelerate discovery in mood disorder thera-peutics is the topic of this article. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biological Psychiatry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFFECTIVE disorders
KW - MENTAL health
KW - SOMATIZATION disorder
KW - PHARMACOLOGY
KW - bipolar disorder
KW - Depression
KW - government/industry collaboration
KW - research resources,
N1 - Accession Number: 7884937; Tamminga, Carol A. 1 Nemeroff, Charles B. 2 Blakely, Randy D. 3 Brady, Linda 4 Carter, Cameron S. 5 Davis, Kenneth L. 6 Dingledine, Raymond 2 Gorman, Jack M. 7 Grigoriadis, Dimitri E. 8 Henderson, David C. 9 B. Innis, Robert 4 Killen, John 10 Laughren, Thomas P. 11 McDonald, William M. 2 M. Murphy Jr, Greer 12 Paul, Steven M. 13 Rudorfer, Matthew V. 4 Sausville, Edward 14 Schatzberg, Alan F. 12 Scolnick, Edward M. 15; Affiliation: 1: Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine (CAT), Baltimore, Maryland, USA 2: Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences (CBN) and Departments of Pharmacology (RD) and Psychiatry (WMM), Emory University, Atlanta, Georgia, USA 3: Department of Pharmacology, Vanderbilt University School of Medicine (RDB), Nashville, Tennessee, USA 4: Neuropharmacology and Drug Discovery and Clinical Therapeutics Programs, Molecular and Cellular Neuroscience Research Branch (LB) and Molecular Imaging Branch (RBI) National Institute of Mental Health (MVR), Bethesda, Maryland, USA 5: Western Psychiatric Institute, Department of Psychiatry, University of Pittsburgh (CSC), Pittsburgh, Pennsylvania, USA 6: Department of Psychiatry, Mt. Sinai School of Medicine (KLD), New York, New York, USA 7: Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons (JMG), New York, New York, USA 8: Neurocrine Biosciences, Inc. (DEG), San Diego, California, USA 9: Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital (DCH), Boston, Massachusetts, USA 10: Division of AIDS, National Institutes of Health/National Institute of Allergy and Infectious Diseases (JK), Bethesda, Maryland, USA 11: Food and Drug Administration (TPL), Rockville, Maryland, USA 12: Psychiatry Neuroscience (GMM) and Department of Psychiatry and Behavioral Sciences (AFS), Stanford University School of Medicine, Stanford, California, USA 13: Lilly Research Laboratories, Eli Lilly and Company (SMP), Indianapolis, Indiana, USA 14: Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute (ES), Rockville, Maryland, USA 15: Merck Research Laboratories (EMS), West Point, Pennsylvania, USA; Source Info: Sep2002, Vol. 52 Issue 6, p589; Subject Term: AFFECTIVE disorders; Subject Term: MENTAL health; Subject Term: SOMATIZATION disorder; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: bipolar disorder; Author-Supplied Keyword: Depression; Author-Supplied Keyword: government/industry collaboration; Author-Supplied Keyword: research resources,; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tauxe, Robert V.
T1 - Emerging foodborne pathogens
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2002/09/15/
VL - 78
IS - 1/2
M3 - Article
SP - 31
SN - 01681605
AB - The broad spectrum of foodborne infections has changed dramatically over time, as well-established pathogens have been controlled or eliminated, and new ones have emerged. The burden of foodborne disease remains substantial: one in four Americans is estimated to have a significant foodborne illness each year. The majority of these illnesses are not accounted for by known pathogens, so more must remain to be discovered. Among the known foodborne pathogens, those more recently identified predominate, suggesting that as more and more is learned about pathogens, they come under control. In addition to the emergence or recognition of new pathogens, other trends include global pandemics of some foodborne pathogens, the emergence of antimicrobial resistance, the identification of pathogens that are highly opportunistic, affecting only the most high-risk subpopulations, and the increasing identification of large and dispersed outbreaks. New pathogens can emerge because of changing ecology or changing technology that connects a potential pathogen with the food chain. They also can emerge de novo by transfer of mobile virulence factors, often through bacteriophage. Though this is rarely observed, it can be reconstructed. Better understanding of the ecology and dynamics of phage transmission among bacteria will help us to understand the appearance of new pathogens in the future. One may look for emerging foodborne pathogens among the silent zoonoses, and among the severe infections affecting the immunocompromised humans. We should expect the unexpected. In the past, separating human sewage and animal manure from human food and water supplies was critical to improving public health. Now, our health depends increasingly on the safety of the feed and water supplies for the animals themselves. The successes of the 20th century and the new challenges we face mean that public health vigilance, careful investigation of new problems, responsible attention to food safety from farm to table, and partnerships to bring about new foodborne disease control measures will be needed for the foreseeable future. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - FOODBORNE diseases
KW - BACTERIA
KW - Bacteria
KW - Disease
KW - Foodborne pathogens
N1 - Accession Number: 7858610; Tauxe, Robert V. 1; Email Address: rvt1@cdc.gov; Affiliation: 1: Chief, Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Mailstop A-38, 1600 Clifton Road, Atlanta, GA 30306, USA; Source Info: Sep2002, Vol. 78 Issue 1/2, p31; Subject Term: PATHOGENIC microorganisms; Subject Term: FOODBORNE diseases; Subject Term: BACTERIA; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Disease; Author-Supplied Keyword: Foodborne pathogens; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Twaddle, Nathan C.
AU - Churchwell, Mona I.
AU - Doerge, Daniel R.
T1 - High-throughput quantification of soy isoflavones in human and rodent blood using liquid chromatography with electrospray mass spectrometry and tandem mass spectrometry detection
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2002/09/25/
VL - 777
IS - 1/2
M3 - Article
SP - 139
SN - 15700232
AB - Soy-containing foods and dietary supplements are widely consumed for putative health benefits (e.g., cancer chemoprevention, beneficial effects on serum lipids associated with cardiovascular health, reduction of osteoporosis, relief of menopausal symptoms). However, studies of soy isoflavones in experimental animals suggest possible adverse effects as well (e.g., enhancement of reproductive organ cancer, modulation of endocrine function, anti-thyroid effects). This paper describes the development and validation of a sensitive high throughput method for quantifying isoflavones in blood from experimental animal and human studies. Serum samples containing genistein, daidzein, and equol were processed using reverse phase solid-phase extraction in the 96-well format for subsequent LC–ES/MS/MS or LC–ES/MS analysis using isotope dilution in conjunction with labeled internal standards. The method was validated by repetitive analysis of spiked blank serum and the intra-day and inter-day accuracy (88–99%) and precision (relative standard deviations from 3 to 13%) of measurement determined. The lower limit of quantification for all isoflavones was approximately 0.005 μM using MS/MS detection, and 0.03 μM using MS for genistein and daidzein. The degree of method performance, with respect to throughput, sensitivity and selectivity, makes this approach practical for analysis of large sample sets generated from mechanistic animal studies and human clinical trials of soy isoflavones. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOYFOODS
KW - ISOFLAVONES
KW - LIQUID chromatography
KW - Isoflavones
N1 - Accession Number: 7879294; Twaddle, Nathan C. 1 Churchwell, Mona I. 1 Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Sep2002, Vol. 777 Issue 1/2, p139; Subject Term: SOYFOODS; Subject Term: ISOFLAVONES; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Isoflavones; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doerge, Daniel R.
AU - Chang, Hebron C.
T1 - Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2002/09/25/
VL - 777
IS - 1/2
M3 - Article
SP - 269
SN - 15700232
AB - Soy-containing foods and dietary supplements are widely consumed for putative health benefits (e.g. cancer chemoprevention, beneficial effects on serum lipids associated with cardiovascular health, reduction of osteoporosis, relief of menopausal symptoms). However, studies of soy isoflavones in experimental animals suggest possible adverse effects as well (e.g. enhancement of reproductive organ cancer, modulation of endocrine function, anti-thyroid effects). This paper reviews the evidence in humans and animals for anti-thyroid effects of soy and its principal isoflavones, genistein and daidzein. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOFLAVONES
KW - IODIDE peroxidase
KW - SOYFOODS
KW - DIETARY supplements
KW - Isoflavones
KW - Thyroid peroxidase
N1 - Accession Number: 7879306; Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov Chang, Hebron C. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Sep2002, Vol. 777 Issue 1/2, p269; Subject Term: ISOFLAVONES; Subject Term: IODIDE peroxidase; Subject Term: SOYFOODS; Subject Term: DIETARY supplements; Author-Supplied Keyword: Isoflavones; Author-Supplied Keyword: Thyroid peroxidase; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 11p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Yan-Sanders, Yan
AU - Hammons, George J.
AU - Lyn-Cook, Beverly D.
T1 - Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/09/26/
VL - 183
IS - 2
M3 - Article
SP - 215
SN - 03043835
AB - Pancreatic cancer is a major cause of deaths in the United States, and has one of the lowest 5-year survival rates. Early diagnosis has not been possible due to the lack of reliable early tumor markers. The heterogeneous nuclear ribonucleoprotein A1/B2 (hnRNP) was recently shown to be up-regulated in the early stage of lung cancer. This protein plays an important role in biogenesis and transport of mRNA. Up-regulation of hnRNP usually precedes morphological differentiation and is considered a good biomarker in the early stages of cancer development. Because smoking is a high risk factor for pancreatic cancer, this study examined the expression of hnRNP in human pancreatic tissues from smokers and non-smokers. A two-fold increase in expression of hnRNP was found overall in smokers when compared to non-smokers and smokers who quit (P<0.05 ). The increase in expression of hnRNP was higher in female smokers compared to female non-smokers. High levels of expression was also shown in a limited number of human pancreatic adenocarcinomas and two pancreatic tumor cell lines, HPAF-11 and SU 86.86. HP-8, a normal primary pancreatic cell line, did not express hnRNP. These results strongly suggest that up-regulation of hnRNP may be a good candidate for early screening for pancreatic cancer because of its activation in pancreatic tissue from smokers and activation in pancreatic adenocarcinomas. Over-expression of hnRNP has been suggested as evidence that normal transcriptional regulation is altered. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PANCREATIC cancer
KW - NUCLEOPROTEINS
KW - hnRNP gene expression
KW - Pancreatic cancer
KW - Smokers
N1 - Accession Number: 7823247; Yan-Sanders, Yan 1 Hammons, George J. 1 Lyn-Cook, Beverly D.; Email Address: bcook@nctr.fda.gov; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Sep2002, Vol. 183 Issue 2, p215; Subject Term: PANCREATIC cancer; Subject Term: NUCLEOPROTEINS; Author-Supplied Keyword: hnRNP gene expression; Author-Supplied Keyword: Pancreatic cancer; Author-Supplied Keyword: Smokers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Reynolds, Brady
AU - de Wit, Harriet
AU - Richards, Jerry B.
T1 - Delay of gratification and delay discounting in rats
JO - Behavioural Processes
JF - Behavioural Processes
Y1 - 2002/09/30/
VL - 59
IS - 3
M3 - Article
SP - 157
SN - 03766357
AB - Delay discounting (DD) and delay of gratification (DG) are two measures of impulsive behavior often viewed as reflecting the same or equivalent processes. However, there are some key differences in the contingencies of reinforcement between the procedures that may have implications for understanding impulsivity. This study used DD and DG procedures to determine if differences in contingencies of reinforcement specified by DD and DG alters how much organisms discount the value of delayed reinforcers. Twenty-four water-deprived rats performed one of two Adjusting Amount procedures, which consisted of repeated choices between a fixed amount of water (250 μl) delivered after a delay (0, 4, 8, 16, or 32 s) and an adjusting, usually lesser amount delivered immediately. Half of the rats (n=12) performed a DD procedure designed to assess preference for immediate over delayed reinforcers in which they had discrete choices between the immediate and delayed amounts of water. A DG procedure was used for the other half of the rats (n=12). In the DG procedure rats also selected between immediate and delayed alternatives, but if they chose the delayed alternative they could switch to and receive the immediate alternative at any time during the delay to the larger reward. In the DD procedure switching responses were not reinforced but were still recorded and used for analyses. The DD functions of the two groups did not differ significantly. However, at the longer delays, the DG group made significantly fewer switching responses than the DD group. A possible role of response inhibition in the DG procedure is discussed. [Copyright &y& Elsevier]
AB - Copyright of Behavioural Processes is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RATS -- Behavior
KW - REINFORCEMENT (Psychology)
KW - Choice
KW - Delay discounting
KW - Delay of gratification
KW - Delayed reinforcement
KW - Impulsivity
KW - Nose poke
KW - Rat
KW - Self-control
KW - Willpower
N1 - Accession Number: 7881827; Reynolds, Brady 1; Email Address: bhr8@cdc.gov de Wit, Harriet 2 Richards, Jerry B. 3; Email Address: jr52@buffalo.edu; Affiliation: 1: Health Communication Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 4050, Morgantown, WV 26506-6040, USA 2: Department of Psychiatry, MC3077, The University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA 3: Department of Pediatrics, 3435 Main Street, Building #26, University of Buffalo, The State University of New York, Buffalo, NY 14214-3000, USA; Source Info: Sep2002, Vol. 59 Issue 3, p157; Subject Term: RATS -- Behavior; Subject Term: REINFORCEMENT (Psychology); Author-Supplied Keyword: Choice; Author-Supplied Keyword: Delay discounting; Author-Supplied Keyword: Delay of gratification; Author-Supplied Keyword: Delayed reinforcement; Author-Supplied Keyword: Impulsivity; Author-Supplied Keyword: Nose poke; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Self-control; Author-Supplied Keyword: Willpower; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Matilde Marques, M.
AU - Gamboa da Costa, Gonçalo
AU - Blankenship, Lonnie R.
AU - Culp, Sandra J.
AU - Beland, Frederick A.
T1 - The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/09/30/
VL - 506/507
M3 - Article
SP - 41
SN - 00275107
AB - 2,6-Dimethylaniline (2,6-DMA) is an intermediate in the manufacture of several products, including pesticides, dyestuffs, and synthetic resins. It is also present in nanogram amounts in tobacco smoke, and is a major metabolite of the potent anesthetic and antiarrhythmic drug lidocaine, as well as a nasal carcinogen in rats. As with other aromatic amines, 2,6-DMA can undergo metabolic activation through cytochrome P450-mediated N-hydroxylation, followed by O-esterification to a reactive derivative capable of forming DNA adducts. We have recently characterized four DNA adducts resulting from this metabolic pathway. Three of the adducts arose from reaction of the exocyclic heteroatoms of deoxyadenosine and deoxyguanosine with the carbon para to the arylamine nitrogen. The fourth adduct resulted from reaction of the 2,6-DMA nitrogen with the C8 atom of deoxyguanosine. In order to investigate the relative contribution of the exocyclic heteroatom adducts as compared to the C8-deoxyguanosine adduct to the toxicities elicited by 2,6-DMA, we synthesized and compared the mutagenicity of N-hydroxy-2,6-DMA, N-hydroxy-4-deutero-2,6-DMA, 2,6-dimethylnitrosobenzene, 4-deutero-2,6-dimethylnitrosobenzene, and N-hydroxy-4-fluoro-2,6-DMA. In Salmonella typhimurium TA100, the two deuterated compounds and their non-deuterated analogues gave similar mutagenic responses (∼25 revertants/nmol). Likewise in S. typhimurium TA98, a similar mutant frequency (∼0.7 revertants/nmol) was obtained with the four compounds. With N-hydroxy-4-fluoro-2,6-DMA, the mutant frequency was reduced by ∼90% in S. typhimurium TA100 and ∼50% in S. typhimurium TA98. The results suggest that multiple adducts contribute to base substitution mutations detected by S. typhimurium TA100 while the C8-deoxyguanosine adduct is primarily responsible for the frameshift mutations detected by S. typhimurium TA98. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIMETHYLANILINE
KW - MUTAGENESIS
KW - 2,6-Dimethylaniline
KW - DNA adducts
KW - Mutagenesis
KW - Salmonella typhimurium
N1 - Accession Number: 7882148; Matilde Marques, M. 1; Email Address: matilde.marques@ist.utl.pt Gamboa da Costa, Gonçalo 1 Blankenship, Lonnie R. 2 Culp, Sandra J. 2 Beland, Frederick A. 2; Affiliation: 1: Centro de Quımica Estrutural, Instituto Superior Técnico, Complexo I, Av. Rovisco Pais, 1049-001 Lisboa, Portugal 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Sep2002, Vol. 506/507, p41; Subject Term: DIMETHYLANILINE; Subject Term: MUTAGENESIS; Author-Supplied Keyword: 2,6-Dimethylaniline; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Mutagenesis; Author-Supplied Keyword: Salmonella typhimurium; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Culp, S.J.
AU - Beland, F.A.
AU - Heflich, R.H.
AU - Benson, R.W.
AU - Blankenship, L.R.
AU - Webb, P.J.
AU - Mellick, P.W.
AU - Trotter, R.W.
AU - Shelton, S.D.
AU - Greenlees, K.J.
AU - Manjanatha, M.G.
T1 - Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/09/30/
VL - 506/507
M3 - Article
SP - 55
SN - 00275107
AB - Leucomalachite green is a persistent and prevalent metabolite of malachite green, a triphenylmethane dye that has been used widely as an antifungal agent in the fish industry. Concern over the use of malachite green is due to the potential for consumer exposure, evidence suggestive of tumor promotion in rodent liver, and suspicion of carcinogenicity based on structure–activity relationships. Our previous study indicated that feeding rodents malachite or leucomalachite green resulted in a dose-related increase in liver DNA adducts, and that, in general, exposure to leucomalachite green caused an increase in the number and severity of changes greater than was observed following exposure to malachite green. To characterize better the genotoxicity of leucomalachite green, female Big Blue® rats were fed leucomalachite green at doses of 0, 9, 27, 91, 272, or 543 ppm for up to 32 weeks. The livers were analyzed for lacI mutations at 4, 16, and 32 weeks and DNA adducts at 4 weeks. Using a 32P -postlabeling assay, we observed a dose-related DNA adduct in the livers of rats fed 91, 272, and 543 ppm leucomalachite green. A ∼3-fold increase in lacI mutant frequency was found in the livers of rats fed 543 ppm leucomalachite green for 16 weeks, but significant increases in mutant frequencies were not found for any of the other doses or time points assayed. We also conducted 2-year tumorigenesis bioassays in female and male F344 rats using 0, 91, 272, and 543 ppm leucomalachite green. Preliminary results indicate an increasing dose trend in lung adenomas in male rats treated with leucomalachite green, but no increase in the incidence of liver tumors in either sex of rat. These results suggest that the DNA adduct formed in the livers of rats fed leucomalachite green has little mutagenic or carcinogenic consequence. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALACHITE
KW - MUTAGENESIS
KW - Carcinogenicity
KW - lacI
KW - Leucomalachite green
KW - Malachite green
KW - Mutagenicity
KW - Transgenic rats
N1 - Accession Number: 7882150; Culp, S.J. 1; Email Address: sculp@nctr.fda.gov Beland, F.A. 1 Heflich, R.H. 1 Benson, R.W. 1 Blankenship, L.R. 1 Webb, P.J. 1 Mellick, P.W. 2 Trotter, R.W. 2 Shelton, S.D. 1 Greenlees, K.J. 3 Manjanatha, M.G. 1; Affiliation: 1: Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Pathology Associates A Charles River Company, Jefferson, AR 72079, USA 3: Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD 20855, USA; Source Info: Sep2002, Vol. 506/507, p55; Subject Term: MALACHITE; Subject Term: MUTAGENESIS; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: lacI; Author-Supplied Keyword: Leucomalachite green; Author-Supplied Keyword: Malachite green; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Transgenic rats; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nowell, Susan
AU - Coles, Brian
AU - Sinha, Rashmi
AU - MacLeod, Stewart
AU - Luke Ratnasinghe, D.
AU - Stotts, Craig
AU - Kadlubar, Fred F.
AU - Ambrosone, Christine B.
AU - Lang, Nicholas P.
T1 - Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/09/30/
VL - 506/507
M3 - Article
SP - 175
SN - 00275107
AB - A case-control study of colorectal cancer, consisting of 157 cases and 380 controls matched by sex, ethnicity, decade of age and county of residence was performed to explore the associations between environmental exposure, metabolic polymorphisms and cancer risk. Participants were required to provide a blood sample, undergo caffeine phenotyping and complete an in-person interview that evaluated meat consumption, cooking methods and degree of doneness. A color atlas of foods cooked to different degrees of doneness was used to estimate food preparation techniques and food models were used to estimate serving portion sizes. Data was analyzed using a reference database of heterocyclic amine (HCA) exposure based on the food preferences chosen from the atlas. Data regarding individual food items cooked to different levels of doneness, as well as summary variables of foods and of food groups cooked to different degrees of doneness were also evaluated in a univariate analysis for association with colorectal cancer case status. Three measures of metabolic variation, hGSTA1 genotype, SULT1A1 genotype and the phenotype for CYP2A6 were also evaluated for possible association with colon cancer.While higher exposure to HCAs was strongly associated with colorectal cancer risk, increased consumption of five red meats cooked well done or very well done produced comparable odds ratios (OR) for colorectal cancer risk (OR=4.36 , 95% CI 2.08–9.60) for the highest quartile of exposure. Similarly, individuals in the most rapid CYP2A6 phenotype quartile showed an odds ratio (OR = 4.18, 95% CI 2.03–8.90). The ORs for the low activity hGSTA1 and low activity SULT1A1 alleles were 2.0, 95% CI 1.0–3.7 and 0.6, 95% CI 0.3–1.1, respectively. Individual measures of specific HCAs provided little improvement in risk assessment over the measure of meat consumption, suggesting that exposure to other environmental or dietary carcinogens such as nitrosamines or undefined HCAs may contribute to colorectal cancer risk. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer
KW - AMINES
KW - Caffeine phenotype
KW - Colorectal cancer
KW - Cytochrome P450 2A6
KW - Genotype
KW - Glutathione S-transferase A1
KW - Heterocyclic amines (HCA)
KW - Sulfotransferase 1A1
N1 - Accession Number: 7882164; Nowell, Susan 1 Coles, Brian 2 Sinha, Rashmi 3 MacLeod, Stewart 4 Luke Ratnasinghe, D. 2 Stotts, Craig 5 Kadlubar, Fred F. 2 Ambrosone, Christine B. 6 Lang, Nicholas P. 4,7; Email Address: nick.lang@med.va.gov; Affiliation: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, AR 72205, USA 2: National Center for Toxicological Research, Jefferson, AR, 72079, USA 3: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892, USA 4: Arkansas Cancer Research Center, 4301 W. Markham Street, Little Rock, AR 72205, USA 5: University of Tennessee Health Science Center, Memphis, TN, USA 6: Mt. Sinai School of Medicine, New York, NY, USA 7: Central Arkansas Veterans Health Care System, 4300 W. 7th Street, Little Rock, AR 72205, USA; Source Info: Sep2002, Vol. 506/507, p175; Subject Term: COLON cancer; Subject Term: AMINES; Author-Supplied Keyword: Caffeine phenotype; Author-Supplied Keyword: Colorectal cancer; Author-Supplied Keyword: Cytochrome P450 2A6; Author-Supplied Keyword: Genotype; Author-Supplied Keyword: Glutathione S-transferase A1; Author-Supplied Keyword: Heterocyclic amines (HCA); Author-Supplied Keyword: Sulfotransferase 1A1; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turesky, Robert J.
AU - Guengerich, F. Peter
AU - Guillouzo, André
AU - Langouët, Sophie
T1 - Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/09/30/
VL - 506/507
M3 - Article
SP - 187
SN - 00275107
AB - The metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was investigated in primary human and rat hepatocytes. The genotoxic metabolites 2-(hydroxyamino)-3,8-dimethylimidazo[4,5-f]quinoxaline (HONH-MeIQx) and 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine (HONH-PhIP), which are formed by cytochrome P4501A2 (CYP1A2), were detected as stable N2-glucuronide and N2- and N3-glucuronide conjugates, respectively. These products accounted for as much as 10% of the amount of MeIQx and 60% of PhIP added to human hepatocytes. Significantly lower amounts of these products were formed in rat hepatocytes. The phase II conjugates N2-(3,8-dimethylimidazo[4,5-f]quinoxalin-2-yl-sulfamic acid (MeIQx-N2-SO3H) and N2-(β-1-glucosiduronyl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx-N2-Gl), as well as the 7-oxo derivatives of MeIQx and N-desmethyl-MeIQx, 2-amino-3,8-dimethyl-6-hydro-7H-imidazo[4,5-f]quinoxalin-7-one (7-oxo-MeIQx), and 2-amino-6-hydro-8-methyl-7H-imidazo[4,5-f]quinoxalin-7-one (N-desmethyl-7-oxo-MeIQx) were also identified. A novel CYP1A2-derived metabolite was characterized as 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid (IQx-8-COOH) and was the predominant metabolite formed in human hepatocytes exposed to MeIQx at levels approaching human exposure. Unlike human hepatocytes, rat cell preparations, even following pretreatment with the potent CYP1A1/CYP1A2 inducer 3-methylcholanthrene (3-MC) did not produce IQx-8-COOH but did catalyze the formation of 2-amino-3,8-dimethyl-5-hydroxyimidazo[4,5-f]quinoxaline (5-HO-MeIQx) as a major CYP-mediated detoxication product. In the case of PhIP, direct glucuronidation of the N2 and N3 positions also occurred in human and rat hepatocytes. Glucuronide and sulfate conjugates of 2-amino-4′-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine (4′-HO-PhIP) were detected as relatively minor metabolites in human hepatocytes but were the major products formed in rat hepatocytes, accounting for up to 50% of the metabolism. Rat CYP1A2, but not the human ortholog, significantly contributes to 4′-hydroxylation of PhIP. Important differences exist between human and rat liver enzymes in catalytic activity and regioselectivity of MeIQx and PhIP metabolism. Some human hepatocyte preparations are more active at transforming MeIQx and PhIP to a genotoxic species than rat hepatocytes pretreated with potent inducer 3-MC. These pronounced interspecies differences in metabolism of MeIQx and PhIP may affect the biological activity of these mutagens and must be considered when assessing human health risk. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROMES
KW - LIVER cells
KW - Cytochrome P4501A2
KW - Hepatocytes
KW - Xenobiotic metabolism
N1 - Accession Number: 7882165; Turesky, Robert J. 1; Email Address: rturesky@nctr.fda.gov Guengerich, F. Peter 2 Guillouzo, André 3 Langouët, Sophie 3; Email Address: sophie.langouet@rennes.inserm.fr; Affiliation: 1: National Center for Toxicological Research, 3900 NCTR Dr., HFT 100 Jefferson, AR 72079-9502, USA 2: Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA 3: INSERM U456, Faculté de Pharmacie, Université de Rennes I, 35043 Rennes, France; Source Info: Sep2002, Vol. 506/507, p187; Subject Term: CYTOCHROMES; Subject Term: LIVER cells; Author-Supplied Keyword: Cytochrome P4501A2; Author-Supplied Keyword: Hepatocytes; Author-Supplied Keyword: Xenobiotic metabolism; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Kristin E.
AU - Sinha, Rashmi
AU - Kulldorff, Martin
AU - Gross, Myron
AU - Lang, Nicholas P.
AU - Barber, Cheryl
AU - Harnack, Lisa
AU - DiMagno, Eugene
AU - Bliss, Robin
AU - Kadlubar, Fred F.
T1 - Meat intake and cooking techniques: associations with pancreatic cancer
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2002/09/30/
VL - 506/507
M3 - Article
SP - 225
SN - 00275107
AB - Heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs), formed in temperature and time-dependent manners during cooking of meat, may increase the risk of certain cancers. As these compounds could be carcinogenic for the pancreas, we assessed meat intake, preparation methods, and doneness preferences as risk factors for exocrine pancreatic cancer.In a case-control study (cases=193 , controls=674 ), subjects provided information on their usual meat intake and how it was cooked, e.g. fried, grilled or barbecued (BBQ), etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness with a numerical scale. Data were analyzed with unconditional logistic regression. Odds ratios (ORs) increased with increased intake of grilled/BBQ red meat in an analysis adjusted for age, sex, smoking, education, race, and diabetes. Based on amount of BBQ meat consumed, the OR and 95% confidence interval (CI) for the fifth quintile relative to the reference group (quintiles 1 and 2) was 2.19 (1.4, 3.4). Findings were not substantively changed by further adjustment for calories, total fat, fruit and vegetables, or alcohol consumption (from a food frequency questionnaire (FFQ)). Other meat variables did not show statistically significant associations with risk nor did they substantively alter the findings for BBQ. These included total meat, processed meat, total red meat, total white meat, total broiled meat, total fried meat, or total meat cooked by means other than grilling. We conclude that grilled red meat intake is a risk factor for pancreatic cancer and that method of meat preparation in addition to total intake is important in assessing the effects of meat consumption in epidemiologic studies. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - PANCREATIC cancer
KW - Cooking practices
KW - Epidemiology
KW - Meat intake
KW - Pancreas cancer
N1 - Accession Number: 7882169; Anderson, Kristin E. 1; Email Address: anderson_k@epi.umn.edu Sinha, Rashmi 2 Kulldorff, Martin 3 Gross, Myron 1 Lang, Nicholas P. 4 Barber, Cheryl 1 Harnack, Lisa 1 DiMagno, Eugene 5 Bliss, Robin 1 Kadlubar, Fred F. 6; Affiliation: 1: University of Minnesota, Minneapolis, MN 55454, USA 2: National Cancer Institute, Rockville, MD 20852, USA 3: School of Medicine, University of Connecticut, Farmington, CT 06030, USA 4: University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 5: Mayo Clinic, Rochester, MN 55905, USA 6: National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Sep2002, Vol. 506/507, p225; Subject Term: EPIDEMIOLOGY; Subject Term: PANCREATIC cancer; Author-Supplied Keyword: Cooking practices; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Meat intake; Author-Supplied Keyword: Pancreas cancer; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Sambo, BH
AU - Malcoe, LH
AU - Eichner, JE
AU - Moore, WE
AU - Lee, ET
AU - Tolbert, B
AU - Rhoades, ER
T1 - #34-S risk factors for diabetes mellitus (Dm) In american indian children and adolescents: Types 2 and 3
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2002/10//
VL - 12
IS - 7
M3 - Abstract
SP - 502
SN - 10472797
AB - PURPOSE: Type 2 diabetes mellitus (DM) has increased dramatically in children and adolescents during the last two decades, especially among American Indians where DM is highly prevalent in the adult population. Risk factors specific to children as well as clinical knowledge about children with non-insulin dependent DM are limited.METHODS: A case-control study was conducted with the assistance of the tribal clinical network and the Oklahoma City Area Indian Health Service; 121 cases (66 boys and 55 girls) were found consisting of 99 Type 2 and 22 Type 3 DM cases. Type 3 shares some features of both Types 1 and 2 DM. Frequency matching by age and facility at birth was used to randomly select 121 controls. Medical and maternal birth records of cases and controls were abstracted.RESULTS: Mean age of DM onset was 12.3 years. Body mass index (BMI) was significantly higher in cases than in controls (32.3 vs. 26.4, p = .002). Mean weight at onset of DM was significantly higher for patients with Type 2 (188 lbs) vs Type 3 DM (121 lbs) [p = .001]. Mean fasting blood glucose at diagnosis was very high, but higher in individuals with Type 3 (539 mg/dl) vs Type 2 DM (411 mg/dl) [p = .003]. Bottle feeding, excessive maternal weight gain during pregnancy, early childhood excessive weight gain and higher birth order were all found to be associated with Type 2 and Type 3 DM.CONCLUSION: Improved surveillance as well as clinical and community-based interventions are needed to address the diabetes epidemic in young American Indians. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-insulin-dependent diabetes -- Risk factors
KW - INDIGENOUS peoples of the Americas
KW - DISEASES
N1 - Accession Number: 7891264; Sambo, BH 1,2,3,4 Malcoe, LH 1,2,3,4 Eichner, JE 1,2,3,4 Moore, WE 1,2,3,4 Lee, ET 1,2,3,4 Tolbert, B 1,2,3,4 Rhoades, ER 1,2,3,4; Affiliation: 1: 1Native American Prev Res Ctr, Univ of Oklahoma Health Sc Ctr,OUHSC, College of Public Health, COPH, OKC, Oklahoma City, OK USA 2: 2Masters in Public Health Program, Univ of New Mexico School of Medicine, Albuquerque, NM USA 3: 3Center for American Indian Health Research, OUHSC, COPH, Oklahoma City, OK USA 4: 4Oklahoma City Area Indian Health Service, OKC, Oklahoma City, OK USA; Source Info: Oct2002, Vol. 12 Issue 7, p502; Subject Term: NON-insulin-dependent diabetes -- Risk factors; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: DISEASES; Number of Pages: 1p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Sullivan, PA
T1 - #64 Predictors of chronic obstructive pulmonary disease among office and school workers
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2002/10//
VL - 12
IS - 7
M3 - Abstract
SP - 513
SN - 10472797
AB - PURPOSE: The aim of this analysis was to identify predictors of chronic obstructive pulmonary disease (COPD) in office and school workers, a subset of the population generally assumed to have a low prevalence of COPD and limited exposure to chemicals and dusts at work.METHODS: National Health and Nutrition Examination Survey (NHANES III) data on 2486 US office workers were analyzed, using SUDAAN to estimate population prevalence of COPD. COPD was defined as FEV1/FVC<70% and FEV1<80% predicted. Based on the literature, risk factors evaluated for airflow obstruction included age, race, sex, body size, education, poverty/income ratio, smoking, alcohol, serum antioxidants, dietary fats, coffee, energy use during exercise, and employment duration. Logistic regression was used to develop a multivariate model to estimate risk of COPD.RESULTS: The population prevalence of COPD among US office and school workers was estimated at 4.7% compared with 8.1% in other US workers. As expected, current smoking was a strong predictor of COPD. After adjusting for age, race, sex, and current smoking, workers with COPD had significantly (p < 0.02) greater mean duration of employment, pack years, alcohol intake, body mass index (BMI), coffee consumption, and dietary fat and cholesterol. Workers with COPD had lower mean serum selenium and energy use during exercise. In multivariate modeling, employment duration, cigarette smoking, age, race, alcohol, use of propane fuel at home, serum antioxidant (selenium), BMI, and exercise were found to explain COPD risk. Compared to other sources of home heat, propane fuel was associated with a 4.2-fold risk of COPD (95% CI 1.2–15.1). Duration of employment as an office or school worker for more than 10 years (vs. < 10 years) was associated with a 1.8-fold (95% CI 1.0–3.3) excess risk of COPD.CONCLUSION: Multivariate modeling revealed several risk factors for COPD amenable to modification, including smoking, alcohol, and propane fuel. Selenium and exercise were found to be protective. The predictive model developed in multivariate logistic regression analysis suggests that, after controlling for other risk factors, working as an office or school worker for 45 years is associated with a 2.4-fold excess risk of COPD. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases
KW - OCCUPATIONAL diseases
N1 - Accession Number: 7891304; Sullivan, PA 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV USA; Source Info: Oct2002, Vol. 12 Issue 7, p513; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: OCCUPATIONAL diseases; Number of Pages: 1p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Michener, Chad M.
AU - Ardekani, Ali M.
AU - Petricoin III, Emmanuel F.
AU - Liotta, Lance A.
AU - Kohn, Elise C.
T1 - Genomics and proteomics: application of novel technology to early detection and prevention of cancer
JO - Cancer Detection & Prevention
JF - Cancer Detection & Prevention
Y1 - 2002/10//
VL - 26
IS - 4
M3 - Article
SP - 249
SN - 0361090X
AB - Advances in molecular biology over the past decade have helped to enhance our understanding of the complex interplay between genetic, transcriptional and translational alterations in human cancers. These molecular changes are the basis for an evolving field of high-throughput cancer discovery techniques using microscopic amounts of patient-based materials. Laser capture microdissection allows pure populations of cells to be isolated from both the tumor and stroma in order to identify subtle differences in RNA and protein expression. Comparative analysis of these alterations between normal, pre-invasive, and invasive tissue using powerful bioinformatics programs has allowed us to identify novel tumor markers, profile complex protein pathways, and develop new molecular-based therapies. Continued refinement of such high-throughput microtechnologies will enable us to rapidly query patient specimens to identify novel methods for early detection, treatment, and follow-up of a wide array of human cancers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Detection & Prevention is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR biology
KW - TECHNOLOGY
KW - CANCER treatment
KW - Cancer
KW - Laser capture microdissection
KW - Molecular-targeted therapies
N1 - Accession Number: 7894262; Michener, Chad M. 1 Ardekani, Ali M. 1 Petricoin III, Emmanuel F. 1 Liotta, Lance A. 1 Kohn, Elise C.; Email Address: kohne@helix.gov; Affiliation: 1: NCI-FDA Clinical Proteomics Program, Laboratory of Pathology, Molecular Signaling Section, Center for Cancer Research, National Cancer Institute and Center for Biologics Evaluation and Research, Food and Drug Administration, Building 10/Room 2A33, Bethesda, MD 20892, USA; Source Info: Oct2002, Vol. 26 Issue 4, p249; Subject Term: MOLECULAR biology; Subject Term: TECHNOLOGY; Subject Term: CANCER treatment; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Laser capture microdissection; Author-Supplied Keyword: Molecular-targeted therapies; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bhandoola, Avinash
AU - Tai, Xuguang
AU - Eckhaus, Michael
AU - Auchincloss, Hugh
AU - Mason, Karen
AU - Rubin, Steven A.
AU - Carbone, Kathryn M.
AU - Grossman, Zvi
AU - Rosenberg, Amy S.
AU - Singer, Alfred
T1 - Peripheral Expression of Self-MHC-II Influences the Reactivity and Self-Tolerance of Mature CD4+ T Cells: Evidence from a Lymphopenic T Cell Model
JO - Immunity
JF - Immunity
Y1 - 2002/10//
VL - 17
IS - 4
M3 - Article
SP - 425
SN - 10747613
AB - While intrathymic MHC expression influences the specificity of developing thymocytes, we considered that peripheral MHC expression might influence the reactivity of postthymic T cells. We now report for CD4+ T cells that peripheral MHC-II expression does influence their reactivity and self-tolerance. Upon transfer into MHC-II-deficient lymphopenic hosts, mature CD4+ T cells were found to acquire an activated memory phenotype and to become: (1) autoreactive against syngeneic MHC-II+ skin grafts, (2) hyperreactive against third-party MHC-II+ skin grafts, and (3) functionally dysregulated, resulting in a lymphoproliferative disorder characterized by intraepithelial infiltrations. Peripheral MHC-II expression appeared to influence CD4+ T cell reactivity by two complementary mechanisms: maintenance of CD4+CD25+ regulatory T cells (“suppression”) and direct dampening of CD4+ T cell reactivity (“tuning”). [Copyright &y& Elsevier]
AB - Copyright of Immunity is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAJOR histocompatibility complex
KW - T cells
N1 - Accession Number: 7904542; Bhandoola, Avinash 1 Tai, Xuguang 1 Eckhaus, Michael 2 Auchincloss, Hugh 3 Mason, Karen 4 Rubin, Steven A. 5 Carbone, Kathryn M. 5 Grossman, Zvi 6,7 Rosenberg, Amy S. 4 Singer, Alfred 1; Email Address: singera@nih.gov; Affiliation: 1: Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892 USA 2: Veterinary Resources Program, National Institutes of Health, Bethesda, MD 20892 USA 3: Transplantation Unit, Massachusetts General Hospital, Boston, MA 02114 USA 4: Division of Therapeutic Proteins, Food and Drug Administration, Bethesda, MD 20892 USA 5: Laboratory of Pediatric and Respiratory Viral Diseases, Food and Drug Administration, Bethesda, MD 20892 USA 6: Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel 7: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 USA; Source Info: Oct2002, Vol. 17 Issue 4, p425; Subject Term: MAJOR histocompatibility complex; Subject Term: T cells; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dolan, Scott P.
AU - Capar, Stephen G.
T1 - Multi-element Analysis of Food by Microwave Digestion and Inductively Coupled Plasma-Atomic Emission Spectrometry
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2002/10//
VL - 15
IS - 5
M3 - Article
SP - 593
SN - 08891575
AB - A microwave digestion procedure for multi-elemental analysis of food was developed using one program to digest a variety of food matrices at the same time. A single program was enabled by an analytical portion mass based on the food''s energy content calculated from macronutrient data (fat, protein and carbohydrate). The procedure allows a maximum mass to be analyzed for each food matrix without adjustment of the microwave digestion program to compensate for the variable reactivity of food matrices. Inductively coupled plasma-atomic emission spectrometry with ultrasonic nebulization was used to determine aluminum, arsenic, boron, barium, calcium, cadmium, cobalt, chromium, copper, iron, potassium, magnesium, manganese, molybdenum, sodium, nickel, phosphorus, lead, selenium, strontium, thallium, vanadium, and zinc. Method validation was performed on seven certified reference materials and 20 foods. Element fortification recovery of foods was acceptable (88–113%) and a majority of available comparisons to reference materials indicated agreement except for aluminum, chromium, and selenium. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Analysis
KW - ATOMIC emission spectroscopy
KW - FOOD -- Composition
KW - atomic emission spectrometry
KW - food
KW - inductively coupled plasma
KW - microwave digestion
KW - multi-element analysis.
N1 - Accession Number: 8518642; Dolan, Scott P. 1 Capar, Stephen G.; Affiliation: 1: Elemental Research Branch (HFS-338), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, 20740-3835, U.S.A.; Source Info: Oct2002, Vol. 15 Issue 5, p593; Subject Term: FOOD -- Analysis; Subject Term: ATOMIC emission spectroscopy; Subject Term: FOOD -- Composition; Author-Supplied Keyword: atomic emission spectrometry; Author-Supplied Keyword: food; Author-Supplied Keyword: inductively coupled plasma; Author-Supplied Keyword: microwave digestion; Author-Supplied Keyword: multi-element analysis.; Number of Pages: 23p; Document Type: Article
L3 - 10.1006/jfca.2002.1064
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shaikh, B.
AU - O'Driscoll, J. L.
AU - Cullison, R.
T1 - Depletion of residues of furosemide, a loop diuretic, in lactating dairy cows.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2002/10//
VL - 25
IS - 5
M3 - Article
SP - 387
EP - 388
PB - Wiley-Blackwell
SN - 01407783
AB - Investigates the depletion of furosemide in milk in a larger number of lactating dairy cows after intravenous administration at an approved therapeutic regimen. Measurement of furosemide in milk using liquid chromatographic procedure; Peak areas of furosemide standard solutions; Appropriate corrections in calculating the furosemide in relevant samples.
KW - FUROSEMIDE
KW - VETERINARY drug residues
KW - MILK yield
KW - COWS -- Physiology
N1 - Accession Number: 7746785; Shaikh, B. 1 O'Driscoll, J. L. 1 Cullison, R. 1; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Oct2002, Vol. 25 Issue 5, p387; Subject Term: FUROSEMIDE; Subject Term: VETERINARY drug residues; Subject Term: MILK yield; Subject Term: COWS -- Physiology; NAICS/Industry Codes: 112120 Dairy Cattle and Milk Production; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1365-2885.2002.00426.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Argaw, Takele
AU - Ritzhaupt, Armin
AU - Wilson, Carolyn A.
T1 - Development of a real time quantitative PCR assay for detection of porcine endogenous retrovirus
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2002/10//
VL - 106
IS - 1
M3 - Article
SP - 97
SN - 01660934
AB - Real time PCR technology was applied to the development of assays for detection and quantitation of porcine endogenous retrovirus (PERV) RNA and DNA sequences in tissues and cells of human or animal origin. A plasmid construct encoding the PERV-pol gene or the in vitro transcribed RNA derived from the plasmid (cRNA) serves as a standard template for amplification of a 178 bp fragment. This study showed that the detection of this target sequence was linear over a range from 20 copies to 2 million copies of the plasmid and from 100 copies to 1 million copies of the cRNA. In addition, amplification of the target sequence was not inhibited by the presence of exogenous genomic DNA. These results demonstrate that a real time (TaqMan-based) PCR or RT–PCR assay can provide a sensitive, reproducible, and robust method for detecting and quantifying PERV DNA or RNA sequences in samples of human or guinea pig origin. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - RETROVIRUSES
KW - Porcine endogenous retrovirus
KW - Real time quantitative PCR
KW - RT–PCR
KW - TaqMan PCR
KW - Xenotransplantation
N1 - Accession Number: 7885306; Argaw, Takele 1 Ritzhaupt, Armin 1 Wilson, Carolyn A.; Email Address: wilsonc@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Source Info: Oct2002, Vol. 106 Issue 1, p97; Subject Term: POLYMERASE chain reaction; Subject Term: RETROVIRUSES; Author-Supplied Keyword: Porcine endogenous retrovirus; Author-Supplied Keyword: Real time quantitative PCR; Author-Supplied Keyword: RT–PCR; Author-Supplied Keyword: TaqMan PCR; Author-Supplied Keyword: Xenotransplantation; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Mihi
AU - Coles, Brian F.
AU - Delongchamp, Robert
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue
JO - Lung Cancer (01695002)
JF - Lung Cancer (01695002)
Y1 - 2002/10//
VL - 38
IS - 1
M3 - Article
SP - 15
SN - 01695002
AB - Individual differences in lung cancer susceptibility should be considered for effective lung cancer prevention. We investigated the CYP2E1, ADH3, and GSTP1 genetic polymorphisms that biotransform xenobiotic carcinogens, and variations of their enzyme activity in Caucasian lung tissues (N=28), and found a variant distribution in pulmonary ADH and CYP2E1 activity. The ADH3*1/*1 subjects (N=8) showed significantly higher ADH activity than ADH3*2/*2 (N=3) subjects (P<0.01). On the other hand, we found a 5-fold variation in the pulmonary CYP2E1 activity using a sensitive HLPC/EC based technique. A subject with the CYP2E1-c/t allele showed 2-fold higher CYP2E1 activity than subjects with the c/c allele (N=14). GSTP1 expression comprised 83% of the total pulmonary GSTs. However, neither the GSTP1 polymorphism, nor other lifestyle factors, such as age, gender, smoking status, were found to be associated with pulmonary GST expression. In conclusion, subjects with the ADH3*1 allele showed higher ADH activity and acetaldehyde–DNA adducts in lung than other subjects; thus, the ADH3*1 allele could be considered a risk factor for lung cancer. [Copyright &y& Elsevier]
AB - Copyright of Lung Cancer (01695002) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROCARBONS
KW - LUNGS -- Cancer
KW - CANCER
KW - CYTOCHROMES
KW - SUSCEPTIBILITY
KW - ADH and ALDH, alcohol and aldehyde dehydrogenase, respectively
KW - COX, cyclooxygenase
KW - CYP, cytochrome P-450
KW - DPEA, 2,4-dichloro-6-phenylphenoxyethylamine
KW - ETYA, 5,8,11,14-eicosatetraynoic acid
KW - GST, glutathione S-transferase
KW - LOX, lipoxygenase
KW - PAHs, polycyclic aromatic hydrocarbons
KW - PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism
N1 - Accession Number: 7885004; Yang, Mihi 1,2; Email Address: myang@snu.ac.kr Coles, Brian F. 2 Delongchamp, Robert 3 Lang, Nicholas P. 4 Kadlubar, Fred F. 2; Affiliation: 1: Department of Preventive Medicine, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon-Dong, Chongno-Gu, 110-799, Seoul, Republic of Korea 2: Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR 72079, USA 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR 72079, USA 4: Central Arkansas Veterans Health Care System, 4300 West 7th, Little Rock, AR 72205, USA; Source Info: Oct2002, Vol. 38 Issue 1, p15; Subject Term: HYDROCARBONS; Subject Term: LUNGS -- Cancer; Subject Term: CANCER; Subject Term: CYTOCHROMES; Subject Term: SUSCEPTIBILITY; Author-Supplied Keyword: ADH and ALDH, alcohol and aldehyde dehydrogenase, respectively; Author-Supplied Keyword: COX, cyclooxygenase; Author-Supplied Keyword: CYP, cytochrome P-450; Author-Supplied Keyword: DPEA, 2,4-dichloro-6-phenylphenoxyethylamine; Author-Supplied Keyword: ETYA, 5,8,11,14-eicosatetraynoic acid; Author-Supplied Keyword: GST, glutathione S-transferase; Author-Supplied Keyword: LOX, lipoxygenase; Author-Supplied Keyword: PAHs, polycyclic aromatic hydrocarbons; Author-Supplied Keyword: PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, R. F.
AU - Kim, S.-J.
AU - Robertson, L. H.
AU - Cerniglia, C. E.
T1 - Development of a membrane-array method for the detection of human intestinal bacteria in fecal samples
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2002/10//
VL - 16
IS - 5
M3 - Article
SP - 341
SN - 08908508
AB - A membrane-array method was developed for the detection of human intestinal bacteria in fecal samples without using the expensive microarray-arrayer and laser-scanner. The 16S rDNA sequences of 20 predominant human intestinal bacterial species were used to design oligonucleotide probes. Three 40-mer oligonucleotides specific for each bacterial species (total 60 probes) were synthesized and applied to nitrocellulose membranes. Digoxigenin (DIG)-labeled 16S rDNAs were amplified by polymerase chain reaction (PCR) from human fecal samples or pure cultured bacteria using two universal primers, and were hybridized to the membrane-array. Hybridization signals were read by NBT/BCIP color development. The 20 intestinal bacterial species tested were Bacteroides thetaiotaomicron, B. vulgatus, B. fragilis, B. distasonis, Clostridium clostridiiforme, C. leptum, Fusobacterium prausnitzii, Peptostreptococcus productus,Ruminococcus obeum , R. bromii, R. callidus, R. albus, Bifidobacterium longum, B. adolescentis, B. infantis, Eubacterium biforme, E. aerofaciens, Lactobacillus acidophilus,Escherichia coli , and Enterococcus faecium. The two universal primers were able to amplify full size 16S rDNA from all of the 20 bacterial species tested. The hybridization results indicated that the membrane-array method is a reliable technique for the detection of predominant human intestinal bacteria in the fecal samples. The result was also confirmed by using specific PCR methods for these bacteria. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTESTINES -- Infections
KW - POLYMERASE chain reaction
KW - membrane-array method, microarray, human intestinal bacteria, PCR, 16S rDNA amplification
N1 - Accession Number: 8619448; Wang, R. F. Kim, S.-J. 1 Robertson, L. H. 1 Cerniglia, C. E. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd. Jefferson, AR, 72079, USA; Source Info: Oct2002, Vol. 16 Issue 5, p341; Subject Term: INTESTINES -- Infections; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: membrane-array method, microarray, human intestinal bacteria, PCR, 16S rDNA amplification; Number of Pages: 10p; Document Type: Article
L3 - 10.1006/mcpr.2002.0432
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8619448&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106808495
T1 - Ethical issues in occupational health research.
AU - Ward EM
AU - Hurrell JJ
AU - Colligan MJ
Y1 - 2002/10//2002 Oct-Dec
N1 - Accession Number: 106808495. Language: English. Entry Date: 20030221. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8605629.
KW - Research Ethics
KW - Health Services Research -- Ethical Issues
KW - Occupational Health Services
KW - Privacy and Confidentiality
KW - Research Subject Recruitment
KW - Specimen Handling
KW - Consent (Research)
KW - Case Studies
SP - 637
EP - 655
JO - Occupational Medicine: State of the Art Reviews
JF - Occupational Medicine: State of the Art Reviews
JA - OCCUP MED STATE ART REV
VL - 17
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - This is an overview of ethical issues in occupational health research involving human subjects. Research that requires human subjects review must be distinguished from surveillance or public health practice. Confidentiality and privacy concerns are particularly important in an occupational setting because individual participants may be identifiable through job title or other characteristics, and because there may be concerns about employment discrimination associated with participation status or results. Additional issues include notification of individual test results to the study participants, including whether the results have clinical significance and/or provide other potentially relevant information to the study subjects; consent for banking of biological specimens for future research (e.g., uses of the specimens, plans for anonymization, notification of future results); and the higher level of sensitivity of workplace studies involving genetic modifiers of risk. Many occupational studies involve no more than minimal risk. Studies that involve greater than minimal risk require the investigator to document the potential risks and attempt to minimize them.
SN - 0885-114X
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106801105
T1 - Guest commentary. Outcomes and effectiveness research: capacity building for nurse researchers at the Agency for Healthcare Research and Quality.
AU - Hubbard H
AU - Walker PH
AU - Clancy CM
AU - Stryer D
Y1 - 2002/10//
N1 - Accession Number: 106801105. Language: English. Entry Date: 20030131. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101150637.
KW - Research, Nursing
KW - Outcomes Research
KW - Nursing Outcomes
KW - United States Agency for Healthcare Research and Quality
KW - Health Services Research
KW - Nurse Researchers
KW - Grants
KW - World Wide Web
KW - Information Resources
SP - 146
EP - 151
JO - Outcomes Management
JF - Outcomes Management
JA - OUTCOMES MANAGE
VL - 6
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1535-2765
AD - Acting Director and Senior Advisor for Nursing, Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, 6010 Executive Boulevard, Suite 300, Rockville, MD 20852; hhubbard@ahrq.gov
U2 - PMID: 12385165.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106801105&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Itzhak, Yossef
AU - Martin, Julio L.
AU - Ali, Syed F.
T1 - Methamphetamine-induced dopaminergic neurotoxicity in mice: Long-lasting sensitization to the locomotor stimulation and desensitization to the rewarding effects of methamphetamine
JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry
Y1 - 2002/10//
VL - 26
IS - 6
M3 - Article
SP - 1177
SN - 02785846
AB - High doses of methamphetamine (METH) cause the depletion of striatal dopaminergic markers; however, little is known about the behavioral consequences of METH-induced neurotoxicity. In the present study, the authors investigated the effect of a neurotoxic dose of METH (5 mg/kg; every 3 h ×3) on the subsequent response of Swiss Webster mice to (a) the psychomotor-stimulating effect of METH and (b) the acquisition and maintenance of conditioned place preference (CPP) by METH. The latter is a paradigm for the assessment of the rewarding properties of abused substances. The administration of the high dose of METH resulted in significant depletion of dopamine (DA) and its metabolites and dopamine transporter (DAT) binding sites in the striatum. The dopaminergic markers were below control levels until the 95th day after METH administration. METH-pretreated mice were sensitized to the psychomotor-stimulating effect of METH (1 mg/kg) as determined on Days 3 and 74 after the initial exposure to the neurotoxic dose of METH. However, the acquisition of CPP by METH (0.5 mg/kg) was markedly reduced in the mice pretreated with the neurotoxic dose of METH compared with the control group. The CPP was maintained for 8 weeks in the control group but not in the METH group. A priming injection of METH (0.5 mg/kg) caused marked reinstatement of place preference in the control group; this response was maintained for three additional weeks. However, the priming injection of METH resulted in diminished place preference in the METH group and the conditioned response dissipated within 3 weeks. These findings suggest that METH-induced striatal dopaminergic neurotoxicity is associated with two opposing and long-lasting behavioral outcomes: (a) sensitization to the psychomotor-stimulating effect of the drug and (b) desensitization to the rewarding properties of the drug. These consequences may be relevant to the psychopathology of METH abuse. [Copyright &y& Elsevier]
AB - Copyright of Progress in Neuro-Psychopharmacology & Biological Psychiatry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHAMPHETAMINE
KW - DOPAMINE
KW - 3,4-dihydroxyphenylacetic acid (DOPAC)
KW - conditioned place preference (CPP)
KW - dopamine (DA)
KW - dopamine transporter (DAT)
KW - homovanillic acid (HVA)
KW - methamphetamine (METH)
KW - nucleus accumbens (NAC)
N1 - Accession Number: 7878687; Itzhak, Yossef 1; Email Address: yitzhak@med.miami.edu Martin, Julio L. 1 Ali, Syed F. 2; Affiliation: 1: Department of Psychiatry and Behavioral Sciences (R-629), Gautier Building Room No. 503, 1011 NW 15th Street, University of Miami School of Medicine, Miami, FL 33136, USA 2: Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, USA; Source Info: Oct2002, Vol. 26 Issue 6, p1177; Subject Term: METHAMPHETAMINE; Subject Term: DOPAMINE; Author-Supplied Keyword: 3,4-dihydroxyphenylacetic acid (DOPAC); Author-Supplied Keyword: conditioned place preference (CPP); Author-Supplied Keyword: dopamine (DA); Author-Supplied Keyword: dopamine transporter (DAT); Author-Supplied Keyword: homovanillic acid (HVA); Author-Supplied Keyword: methamphetamine (METH); Author-Supplied Keyword: nucleus accumbens (NAC); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106791061
T1 - Public health notification: PVC devices containing the plasticizer DEHP.
AU - Feigal DW Jr.
Y1 - 2002/10//2002 Oct-Dec
N1 - Accession Number: 106791061. Language: English. Entry Date: 20030103. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913099.
KW - Polyvinyls
KW - Equipment and Supplies
KW - Risk Factors
SP - 17
EP - 17
JO - South Carolina Nurse
JF - South Carolina Nurse
JA - SC NURSE
VL - 9
IS - 4
CY - Columbia, South Carolina
PB - South Carolina Nurses Association
SN - 1046-7394
AD - Director, Center for Devices and Radiological Health, Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Apte, Udayan M.
AU - Limaye, Pallavi B.
AU - Ramaiah, Shashi K.
AU - Vaidya, Vishal S.
AU - Bucci, Thomas J.
AU - Warbritton, Alan
AU - Mehendale, Harihara M.
T1 - Upregulated Promitogenic Signaling via Cytokines and Growth Factors: Potential Mechanism of Robust Liver Tissue Repair in Calorie-Restricted Rats upon Toxic Challenge.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/10//
VL - 69
IS - 2
M3 - Article
SP - 448
EP - 459
PB - Oxford University Press / USA
SN - 10966080
AB - Previously we reported that moderate calorie restriction or diet restriction (DR, calories reduced by 35% for 21 days) in male Sprague-Dawley rats protects from a lethal dose of thioacetamide (TA). DR rats had 70% survival compared with 10% in rats fed ad libitum (AL) because of timely and adequate compensatory liver cell division and tissue repair in the DR rats. Further investigation of the mechanisms indicate that enhanced promitogenic signaling plays a critical role in this stimulated tissue repair. Expression of stimulators of promitogenic signaling interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), hepatocyte growth factor (HGF), transforming growth factor-α (TGF-α), and epidermal growth factor receptor (EGFR) were studied during liver tissue repair after TA-induced liver injury. Plasma IL-6 was significantly higher in the DR rats, with 6-fold higher expression at 48 h after TA administration. Immunohistochemical localization revealed significantly higher expression of IL-6 in the hepatic sinusoidal endothelium of DR rats. Expression of TGF-α and HGF was consistently higher in the livers of DR rats from 36 to 72 h. EGFR, which serves as a receptor for TGF-α, was higher in DR rats before TA administration and remained higher till 48 h after TA intoxication. DR-induced 2-fold increase in hepatic iNOS activity is consistent with early cell division in DR rats after TA challenge. These data suggest that the reason behind the higher liver tissue repair after TA-induced hepatotoxicity in DR rats is timely and higher expression of the growth stimulatory cytokines and growth factors. It appears that the physiological effects of DR make the liver cells vigilant and prime the liver tissue promptly for liver regeneration through promitogenic signaling upon toxic challenge. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cell division (Biology)
KW - Cytokines
KW - Rats as laboratory animals
KW - Low-calorie diet
KW - Growth factors
KW - EGFR
KW - Epidermal growth factor receptor
KW - hepatocyte growth factor
KW - HGF
KW - IL-6
KW - TGF-α
KW - TGF-α
KW - thioacetamide
KW - tissue repair
KW - TNF-α
KW - TNF-α
N1 - Accession Number: 44406414; Apte, Udayan M. 1; Limaye, Pallavi B. 1; Ramaiah, Shashi K. 1; Vaidya, Vishal S. 1; Bucci, Thomas J. 2; Warbritton, Alan 2; Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliations: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Sugar Hall #306B, Monroe, Louisiana 71209-0495; 2: Pathology Associates International, National Center For Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Oct2002, Vol. 69 Issue 2, p448; Thesaurus Term: Cell division (Biology); Subject Term: Cytokines; Subject Term: Rats as laboratory animals; Subject Term: Low-calorie diet; Subject Term: Growth factors; Author-Supplied Keyword: EGFR; Author-Supplied Keyword: Epidermal growth factor receptor; Author-Supplied Keyword: hepatocyte growth factor; Author-Supplied Keyword: HGF; Author-Supplied Keyword: IL-6; Author-Supplied Keyword: TGF-α; Author-Supplied Keyword: TGF-α; Author-Supplied Keyword: thioacetamide; Author-Supplied Keyword: tissue repair; Author-Supplied Keyword: TNF-α; Author-Supplied Keyword: TNF-α; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Illustrations: 5 Diagrams, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2002-08276-008
AN - 2002-08276-008
AU - Vase, Lene
AU - Riley, Joseph L. III
AU - Price, Donald D.
T1 - A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2002/10//
VL - 99
IS - 3
SP - 443
EP - 452
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Price, Donald D., Dept of Oral & Maxillofacial Surgery, Health Science Ctr, U Florida, PO Box 100416, Gainesville, FL, US, 32610-0416
N1 - Accession Number: 2002-08276-008. PMID: 12406519 Partial author list: First Author & Affiliation: Vase, Lene; U Aarhus, Dept of Psychology, Risskov, Denmark. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20030512. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Analgesia; Experimental Design; Pain; Placebo. Classification: Physiological Processes (2540); Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Meta Analysis. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2002.
AB - A previous meta-analysis of clinical analgesic trial studies showed generally low magnitudes of placebo analgesia (A. Hrobjartsson and P. C. Gotzsche, 2001). However, as studies included in the analysis used only placebo as a control condition, we conducted 2 meta-analyses, one in which 23 studies used only placebo as a control condition, and one in which 14 studies investigated placebo analgesic mechanisms. Magnitudes of placebo analgesic effects were much higher in the latter (mean effect size = 0.95) compared to the former (mean effect size = 0.15) and were significantly different (P = 0.003). This difference as well as differences in effect sizes within studies of placebo mechanisms may be parsimoniously explained by differences in expected pain levels produced by placebo suggestions and by conditioning. Furthermore, some of the studies of placebo analgesic mechanisms indicate that the magnitude of placebo analgesia is higher when the placebo analgesic effect is induced via suggestion combined with conditioning than via suggestion alone or conditioning alone. Based on these findings, we suggest that placebo analgesic effects are most optimally conceptualized in terms of perception of the placebo agent, and therefore a new definition of placebo response is proposed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical trial studies
KW - placebo analgesic mechanisms
KW - placebo analgesia
KW - placebo as control
KW - placebo response
KW - placebo effects
KW - pain levels
KW - 2002
KW - Analgesia
KW - Experimental Design
KW - Pain
KW - Placebo
KW - 2002
DO - 10.1016/S0304-3959(02)00205-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-08276-008&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8971-7184
UR -
UR - dprice@dental.ufl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Liu, Mingjuan
AU - Reimschuessel, Renate
AU - Hassel, Bret A.
T1 - Molecular cloning of the fish interferon stimulated gene, 15 kDa (ISG15) orthologue: a ubiquitin-like gene induced by nephrotoxic damage
JO - Gene
JF - Gene
Y1 - 2002/10/02/
VL - 298
IS - 2
M3 - Article
SP - 129
SN - 03781119
AB - In mammals, the response to nephrotoxicant-induced renal injury is limited to repair of the proximal tubule by surviving epithelial cells. In contrast, bony fish are capable of both repair, and de novo production of nephrons in response to renal damage. Importantly, toxicant-induced nephron neogenesis in goldfish (Carassius auratus) parallels nephron development in the mammalian embryo, providing a vertebrate model for kidney development. We utilized this model system to identify genes induced by the renal toxicant, gentamicin, that may function in nephron neogenesis. A novel ubiquitin-like (UBL) gene, 40.1, was identified by differential display analysis of control and gentamicin-treated goldfish kidney. 40.1 was induced dramatically 3–7 days following a sublethal dose of gentamicin, and returned to basal level by 14 days post-treatment. The induction of 40.1 coincided with early renal injury in the proximal tubules of gentamicin-injected fish; however, expression was not restricted to the kidney, suggesting that 40.1 induction may be a more general response to cell injury. Sequence analysis revealed that 40.1 contains tandem UBL domains, and shares homology with ISG15, a 15 kD interferon-(IFN) stimulated UBL found in mammals. Analysis of the genome database for the pufferfish, Fugu rubrides, identified a goldfish ISG15 (gfISG15) homologue with an IFN-stimulated response element in the promoter region, providing further evidence that gfISG15 is the true teleost ISG15 orthologue. Zebrafish and catfish ISG15 genes were subsequently identified by sequence analysis. Consistent with its predicted function as a UBL, gfISG15 formed conjugates with cellular proteins in vitro and in transient transfections. Similar to the induction of mammalian ISG15 by microbial challenge, gfISG15 was induced in the spleen of mycobacteria-infected fish. These studies identified the first teleost ISG15 orthologue. The induction of gfISG15 as an early genetic event in response to a renal toxicant, and its conserved, stress-associated, expression in higher vertebrates suggests that ISG15 is an important component of the host response to diverse stress stimuli. [Copyright &y& Elsevier]
AB - Copyright of Gene is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIAL cells
KW - FISHES
KW - KIDNEY diseases
KW - INTERFERONS
KW - ddRT-PCR, differential display
KW - fUBL, fish Ub-like gene/protein
KW - gfISG15, goldfish ISG15
KW - H&E, hematoxylin and eosin
KW - IFN, interferon
KW - ISG15, IFN stimulated gene, 15 kDa
KW - pfISG15, pufferfish ISG15
KW - RACE, rapid amplification of cDNA ends
KW - Ub, ubiquitin
KW - UBL, Ub-like gene/protein
N1 - Accession Number: 7920855; Liu, Mingjuan 1 Reimschuessel, Renate 2 Hassel, Bret A. 1,3; Email Address: bhassel@som.umaryland.edu; Affiliation: 1: Molecular and Cellular Biology Program, University of Maryland, Baltimore, 108 N. Greene Street, Baltimore, MD 21201, USA 2: Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708, USA 3: Greenebaum Cancer Center, University of Maryland, 9th floor BRB, 655 West Baltimore Street, Baltimore, MD 21201, USA; Source Info: Oct2002, Vol. 298 Issue 2, p129; Subject Term: EPITHELIAL cells; Subject Term: FISHES; Subject Term: KIDNEY diseases; Subject Term: INTERFERONS; Author-Supplied Keyword: ddRT-PCR, differential display; Author-Supplied Keyword: fUBL, fish Ub-like gene/protein; Author-Supplied Keyword: gfISG15, goldfish ISG15; Author-Supplied Keyword: H&E, hematoxylin and eosin; Author-Supplied Keyword: IFN, interferon; Author-Supplied Keyword: ISG15, IFN stimulated gene, 15 kDa; Author-Supplied Keyword: pfISG15, pufferfish ISG15; Author-Supplied Keyword: RACE, rapid amplification of cDNA ends; Author-Supplied Keyword: Ub, ubiquitin; Author-Supplied Keyword: UBL, Ub-like gene/protein; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 7437463
T1 - From the Food and Drug Administration.
AU - Crawford Jr., Lester M.
AU - Crawford, Lester M Jr
Y1 - 2002/10/02/
N1 - Accession Number: 7437463. Language: English. Entry Date: 20030103. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Clinical Decision Making in Nursing Scale (CDMNS) (Jenkins); Frenchay Dysarthria Assessment (FDA). NLM UID: 7501160.
KW - Hormone Replacement Therapy
KW - Pharmacy, Retail -- Standards
KW - Clinical Trials -- Standards
KW - Estrogens, Conjugated -- Therapeutic Use
KW - Drug Compounding -- Standards
KW - Blood Glucose Self-Monitoring -- Equipment and Supplies
KW - Medroxyprogesterone Acetate -- Therapeutic Use
KW - Scientific Misconduct
KW - Child
KW - Biosensing Techniques
KW - United States Food and Drug Administration
KW - Postmenopause
KW - Adult
KW - Drug Combinations
KW - Adolescence
KW - Female
KW - United States
KW - Pharmacy, Retail -- Legislation and Jurisprudence
KW - Clinical Assessment Tools
KW - Scales
SP - 1579
EP - 1579
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 288
IS - 13
CY - Chicago, Illinois
PB - American Medical Association
AB - Offers news briefs from the U.S. Food and Drug Administration (FDA) for October 2, 2002. Approval of the Gluco-Watch G2 Biographer, a glucose monitoring device for the assessment of hyperglycemia and hypoglycemia in children and adolescents; FDA guide for its approach to regulating compounded drugs; FDA statement on conjugated equine estrogen/medroxyprogesterone acetate, or Prempro; Web site with an advisory on clinical holds.
SN - 0098-7484
AD - Office of the Commissioner, US Food and Drug Administration, Rockville, MD 20857, USA
U2 - PMID: 12350176.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106848532
T1 - Retinal repair risks.
AU - Woo E
Y1 - 2002/10/07/2002 Oct 7
N1 - Accession Number: 106848532. Language: English. Entry Date: 20030711. Revision Date: 20150711. Publication Type: Journal Article; brief item. Note: Published in multiple journals. Journal Subset: Nursing; USA. NLM UID: 9421079.
KW - Blindness
KW - Nitrous Oxide -- Adverse Effects
KW - Postoperative Complications -- Prevention and Control
KW - Retina -- Surgery
KW - Male
KW - Prostatectomy
KW - Surgical Patients
SP - 27
EP - 27
JO - Nursing Spectrum -- Washington DC & Baltimore Edition
JF - Nursing Spectrum -- Washington DC & Baltimore Edition
JA - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL - 12
IS - 20
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1098-9153
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Doerge, Daniel R.
AU - Twaddle, Nathan C.
AU - Banks, Elizabeth Padilla
AU - Jefferson, Wendy N.
AU - Newbold, Retha R.
T1 - Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal mice
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/10/08/
VL - 184
IS - 1
M3 - Article
SP - 21
SN - 03043835
AB - Genistein, the principal soy isoflavone, was previously shown to induce uterine adenocarcinomas by 18 months of age in female CD-1 mice following administration by subcutaneous injections on postnatal days 1–5. A serum pharmacokinetic analysis of genistein in male and female mice treated identically showed that: maximal concentrations of total (conjugated+aglycone) genistein in females (6.8±1.4 μM) and males (3.8±1.1 μM, mean±SD) were comparable to those previously reported from dietary exposures in adult rats or in human infants consuming soy formulas; the average fraction present as active aglycone (31%) was similar to those in fetal and neonatal rats from placental and lactational exposures; and elimination half-times were longer than those in rats (three- to seven-fold) and adult humans (two- to three-fold). These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOFLAVONES
KW - PHARMACOKINETICS
KW - UTERUS -- Cancer
KW - Genistein
KW - Mass spectrometry
KW - Pharmacokinetics
KW - Phytoestrogen
KW - Soy
KW - Uterine cancer
N1 - Accession Number: 7835704; Doerge, Daniel R. 1; Email Address: ddoerge@nctr.fda.gov Twaddle, Nathan C. 1 Banks, Elizabeth Padilla 2 Jefferson, Wendy N. 2 Newbold, Retha R. 2; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Source Info: Oct2002, Vol. 184 Issue 1, p21; Subject Term: ISOFLAVONES; Subject Term: PHARMACOKINETICS; Subject Term: UTERUS -- Cancer; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Phytoestrogen; Author-Supplied Keyword: Soy; Author-Supplied Keyword: Uterine cancer; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - D’Agnillo, Felice
AU - Alayash, Abdu I.
T1 - A role for the myoglobin redox cycle in the induction of endothelial cell apoptosis
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2002/10/15/
VL - 33
IS - 8
M3 - Article
SP - 1153
SN - 08915849
AB - This study investigates the potential role of the ferric/ferryl redox cycle of myoglobin (Mb) in the development of endothelial cell injury. Bovine aortic endothelial cells were incubated with ferric Mb (0.5–100 μM) in the presence or absence of low steady states of H2O2 (3–4 μM) generated by glucose oxidase (GOX). The reaction of ferric Mb with H2O2 generated ferryl Mb as monitored spectrophotometrically. Ferryl Mb formation correlated with the induction of apoptosis as indicated by morphological criteria, caspase 3 activation, phosphatidylserine (PS) externalization, and nuclear condensation by Hoechst 33342 staining. The addition of ascorbate or catalase inhibited the formation of ferryl Mb and the onset of apoptosis, whereas apoptosis was enhanced in cells depleted of intracellular glutathione by pretreatment with buthionine sulfoximine. Mb and Mb/GOX suppressed cell cycle progression, but only Mb/GOX produced significant cell loss revealed by the accumulation of sub G1 events. These results suggest a role for the Mb redox cycle in the induction of endothelial cell apoptosis, which may be relevant in the pathophysiology of diseases characterized by the release of Mb from damaged muscle. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOGLOBIN
KW - CELL cycle
KW - APOPTOSIS
KW - Apoptosis
KW - Cell cycle
KW - Free radicals
KW - Hydrogen peroxide
KW - Myoglobin
KW - Oxidative stress
KW - Rhabdomyolysis
KW - Vascular injury
N1 - Accession Number: 7892909; D’Agnillo, Felice 1; Email Address: dagnillo@cber.fda.gov Alayash, Abdu I. 1; Affiliation: 1: Laboratory of Plasma Derivatives, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Oct2002, Vol. 33 Issue 8, p1153; Subject Term: MYOGLOBIN; Subject Term: CELL cycle; Subject Term: APOPTOSIS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cell cycle; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Hydrogen peroxide; Author-Supplied Keyword: Myoglobin; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Rhabdomyolysis; Author-Supplied Keyword: Vascular injury; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106808768
T1 - Preventing young worker fatalities: the Fatality Assessment and Control Evaluation (FACE) Program.
AU - Higgins DN
AU - Tierney J
AU - Hanrahan L
Y1 - 2002/11//2002 Nov
N1 - Accession Number: 106808768. Language: English. Entry Date: 20030221. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8608669.
KW - Adolescent Health Services -- Administration
KW - Accidents, Occupational -- Prevention and Control
KW - Child Health Services -- Administration
KW - National Institute for Occupational Safety and Health
KW - Occupational Health Services -- Administration
KW - Occupational-Related Injuries -- Mortality
KW - Prospective Studies
KW - Cause of Death
KW - Employment
KW - Industry
KW - Nursing Role
KW - Occupational Health
KW - Occupational Health Nursing
KW - Disease Surveillance
KW - Program Evaluation
KW - Risk Factors
KW - United States
KW - Wisconsin
KW - Child
KW - Adolescence
KW - Male
KW - Female
KW - Human
SP - 508
EP - 514
JO - AAOHN Journal
JF - AAOHN Journal
JA - AAOHN J
VL - 50
IS - 11
CY - Thorofare, New Jersey
PB - SLACK Incorporated
AB - During the period between 1992 through 1998, the Bureau of Labor Statistics identified an average of 67 work related deaths of individuals younger than 18 each year. This article describes the Fatality Assessment and Control Evaluation (FACE) program and summarizes indepth data collected on 59 young worker fatalities in 26 states. These investigations were conducted between May 1986 and February 2002. Young workers ranged in age from 9 to 17 years, with a mean age of 15.3 years: 21 were working in the agriculture, forestry, and fishing industry; 12 in construction; 10 in manufacturing; 8 in services; and 8 in the retail industry. The majority worked as laborers. Ninety-three percent were young men. Each investigation resulted in the formulation and dissemination of strategies to help prevent future similar occurrences. As an example of state FACE activities, the article describes the Wisconsin FACE program's efforts to foster collaboration between regulatory agencies, researchers, educators, and occupational safety and health professionals, and to integrate efforts aimed at improving safety for young workers.
SN - 0891-0162
AD - Safety and Occupational Health Specialist, Division of Safety Research, Fatality Assessment and Control Evaluation Team, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 12465207.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106840189
T1 - Things my data never told me.
AU - Weinick RM
Y1 - 2002/11//
N1 - Accession Number: 106840189. Language: English. Entry Date: 20030613. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Emergency Care
KW - Emergency Medicine
KW - Emergency Service
KW - Quality of Health Care
KW - Health Resource Utilization
KW - Trauma Centers
KW - Data Collection
KW - Health Services Research
SP - 1071
EP - 1073
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 9
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1069-6563
AD - Center for Primary Care Research, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 12414453.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106840191
T1 - 'Crossing the quality chasm' in emergency medicine...presented at the AEM Consensus Conference on 'Assuring Quality,' May 2002, St. Louis, MO
AU - Burstin H
Y1 - 2002/11//
N1 - Accession Number: 106840191. Language: English. Entry Date: 20030613. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Emergency Care
KW - Emergency Medicine
KW - Emergency Service
KW - Quality Improvement
KW - Patient Safety
KW - Congresses and Conferences -- Missouri
KW - Treatment Errors -- Prevention and Control
KW - Health Resource Utilization
KW - Health Services Accessibility
KW - Patient Centered Care
KW - Missouri
SP - 1074
EP - 1077
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 9
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1069-6563
AD - Center for Primary Care Research, 6010 Executive Boulevard, Suite 201, Rockville, MD 20852; hburstin@ahrq.gov
U2 - PMID: 12414454.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106799494
T1 - Health care for children and youth in the United States: 2001 annual report on access, utilization, quality, and expenditures.
AU - Elixhauser A
AU - Machlin SR
AU - Zodet MW
AU - Chevarley FM
AU - Patel N
AU - McCormick MC
AU - Simpson L
Y1 - 2002/11//2002 Nov-Dec
N1 - Accession Number: 106799494. Language: English. Entry Date: 20030124. Revision Date: 20150711. Publication Type: Journal Article; statistics; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Child Health Services
KW - Adolescent Health Services
KW - Health Services Accessibility
KW - Quality of Health Care
KW - Insurance, Health
KW - Infant, Newborn
KW - Infant
KW - Child, Preschool
KW - Child
KW - Adolescence
SP - 419
EP - 437
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 2
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVES: To provide an update on insurance coverage, use of health care services, and health expenditures for children and youth in the United States and new information on parents' perceived quality of care for their children and to provide information on variation in hospitalizations for children from a 24-state hospital discharge data source. METHODS: The data on insurance coverage, utilization, expenditures, and perceived quality of care come from the Medical Expenditure Panel Survey. The data on hospitalizations come from the Nationwide Inpatient Sample, which is part of the Healthcare Cost and Utilization Project. Both data sets are maintained by the Agency for Healthcare Research and Quality. RESULTS: In 2000, 64.5% of children were privately insured, 21.6% were insured through public sources, and 13.9% were uninsured. Children aged 15-17 years were more likely to be uninsured than children 1-4 years old. Children without health insurance coverage were less likely to use health care services, and when they did, their rates of utilization and expenditures were lower than insured children. Publicly insured children were the most likely to use hospital inpatient and emergency department (ED) care. Being black or Hispanic and living in families with incomes below 200% of the poverty line were associated with lower utilization and expenditures. A small proportion of children account for the bulk of health care expenditures: approximately 80% of all children's health care expenditures are attributable to 20% of children who used medical services. Although most parents report that their experiences with health care for their children are good, there are significant variations by type of insurance coverage. There are substantial differences in average length of hospitalization across the United States, ranging from 2.9-4.1 days, and rates of hospital admission through the ED, which vary across states from 10%-25%. Injuries are a major reason for hospitalization, accounting for 1 in 6 hospital stays among 10- to 14-year-olds. In the 10- to 17-year age group, more than 1 in 7 hospital stays are due to mental disorders. Among 15- to 17-year-olds, more than one third of all hospital stays are related to childbirth and pregnancy. The top 10 most common conditions treated in the hospital account for 40%-60% of all hospital stays. CONCLUSION: Children's use of health care services varies considerably by the type of health insurance coverage, race/ethnicity, and family income. Quality of care, as measured by parents' experiences of care, also varies by type of coverage. There is substantial variation in use of hospital services across states.
SN - 1530-1567
AD - Senior Research Scientist, Agency for Healthcare Research and Quality, 2101 East Jefferson St, Suite 605, Rockville, MD 20852; aelixhau@ahrq.gov
U2 - PMID: 12437388.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - ZIMMER, ANTHONY T.
AU - MAYNARD, ANDREW D.
T1 - Investigation of the Aerosols Produced by a High-speed, Hand-held Grinder Using Various Substrates.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2002/11//
VL - 46
IS - 8
M3 - Article
SP - 663
EP - 672
SN - 00034878
AB - Mechanical processes such as grinding are classically thought to form micrometer scale aerosols through abrasion and attrition. High-speed grinding has been used as the basis for testing the hypothesis that ultrafine particles do not form a substantial component of mechanically generated aerosols. A wide variety of grinding substrates were selected for evaluation to represent the broad spectrum of materials available. To characterize the particle size distribution over particle sizes ranging from 4.2 nm to 20.5 µm, the aerosol-laden air collected from an enclosed chamber was split and directed to three aerosol instruments operated in parallel. Transmission electron microscope samples of the various grinding substrates were also collected. The results demonstrate that ultrafine particles do have the potential to form a significant component of a grinding aerosol for a number of substrates. It appears that the ultrafine aerosols were formed by the following processes: (i) from within the grinding motor, (ii) from the combustion of amenable grinding substrates and (iii) from volatilization of amenable grinding materials at the grinding wheel/substrate interface. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Particles
KW - Beryllium
KW - Micrometers (Instruments)
KW - Transmission electron microscopes
KW - Grinding & polishing
KW - grinding
KW - particle size distribution
KW - ultrafine aerosols
N1 - Accession Number: 44400215; ZIMMER, ANTHONY T. 1; Email Address: azimmer@cdc.gov; MAYNARD, ANDREW D. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: Nov2002, Vol. 46 Issue 8, p663; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Particles; Thesaurus Term: Beryllium; Subject Term: Micrometers (Instruments); Subject Term: Transmission electron microscopes; Subject Term: Grinding & polishing; Author-Supplied Keyword: grinding; Author-Supplied Keyword: particle size distribution; Author-Supplied Keyword: ultrafine aerosols; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; Number of Pages: 10p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mef089
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ng, Chilton
AU - Losso, Jack N.
AU - Marshall, Wayne E.
AU - Rao, Ramu M.
T1 - Freundlich adsorption isotherms of agricultural by-product-based powdered activated carbons in a geosmin–water system
JO - Bioresource Technology
JF - Bioresource Technology
Y1 - 2002/11//
VL - 85
IS - 2
M3 - Article
SP - 131
SN - 09608524
AB - The present study was designed to model the adsorption of geosmin from water under laboratory conditions using the Freundlich isotherm model. This model was used to compare the efficiency of sugarcane bagasse and pecan shell-based powdered activated carbon to the efficiency of a coal-based commercial activated carbon (Calgon Filtrasorb 400). When data were generated from Freundlich isotherms, Calgon Filtrasorb 400 had greater geosmin adsorption at all geosmin concentrations studied than the laboratory produced steam-activated pecan shell carbon, steam-activated bagasse carbon, and the CO2 -activated pecan shell carbon. At geosmin concentrations<0.07 μ g/l for the phosphoric acid-activated pecan shell carbon and below 0.08 μ g/l for a commercially produced steam-activated pecan shell carbon obtained from Scientific Carbons, these two carbons had a higher calculated geosmin adsorption than Filtrasorb 400. While the commercial carbon was more efficient than some laboratory prepared carbons at most geosmin concentrations, the results indicate that when the amount of geosmin was below the threshold level of human taste (about 0.10 μ g/l), the phosphoric acid-activated pecan shell carbon and the Scientific Carbons sample were more efficient than Filtrasorb 400 at geosmin removal. [Copyright &y& Elsevier]
AB - Copyright of Bioresource Technology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural wastes
KW - Activated carbon
KW - Bagasse
KW - Pecan
KW - Adsorption isotherm
KW - Freundlich model
KW - Geosmin
KW - Pecan shells
KW - Sugarcane bagasse
N1 - Accession Number: 7850662; Ng, Chilton 1; Losso, Jack N. 2; Email Address: jlosso@lsu.edu; Marshall, Wayne E. 3; Rao, Ramu M. 2; Affiliations: 1: Department of Health and Human Services, Food and Drug Administration, Kansas City District, P.O. Box 15905, Lenexa, KS 66285-5905, USA; 2: Department of Food Science, Louisiana State University Agricultural Center, 111 Food Science Building, Baton Rouge, LA 70820, USA; 3: USDA-ARS, Southern Regional Research Center, 1100 Robert E. Lee Blvd., P.O. Box 19687, New Orleans, LA 70179, USA; Issue Info: Nov2002, Vol. 85 Issue 2, p131; Thesaurus Term: Agricultural wastes; Thesaurus Term: Activated carbon; Subject Term: Bagasse; Subject Term: Pecan; Author-Supplied Keyword: Adsorption isotherm; Author-Supplied Keyword: Freundlich model; Author-Supplied Keyword: Geosmin; Author-Supplied Keyword: Pecan shells; Author-Supplied Keyword: Sugarcane bagasse; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111335 Tree Nut Farming; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - García-Palacios, A.
AU - Botella, C.
AU - Robert, C.
AU - Baños, R.
AU - Perpiñá, C.
AU - Quero, S.
AU - Ballester, R.
T1 - Clinical utility of cognitive-behavioural treatment for panic disorder. results obtained in different settings: a research centre and a public mental health care unit.
JO - Clinical Psychology & Psychotherapy
JF - Clinical Psychology & Psychotherapy
Y1 - 2002/11//Nov/Dec2002
VL - 9
IS - 6
M3 - Article
SP - 373
EP - 383
PB - John Wiley & Sons, Inc.
SN - 10633995
AB - Cognitive-Behavioural programmes have become the treatment of choice for Panic Disorder (PD). However, although its effectiveness has been widely demonstrated, there are still some limitations regarding the possibility of offering this type of treatment to all panic sufferers. Some researchers are studying ways to make these programmes more available. This study deals with the application and testing of treatment programmes for PD in sites where patients usually look for help for their psychological problems, i.e. mental health care centres. Our work follows a strategy of benchmarking, and the results obtained after applying the treatment in habitual clinical contexts are compared with the results obtained after applying it in research contexts. In the present work, we analyse the possibility of ‘transporting’ a group cognitive-behavioural programme for PD, developed in a research context, to a more natural setting, a public mental health unit. In this work we present data, using a benchmarking strategy, on one hand, on the differential effectiveness of a group cognitive-behavioural treatment for PD applied in two different settings: a research setting—a clinical unit at the university; and a natural setting—a public mental health unit. On the other hand, we compare our results with those achieved by other studies carried out in research settings in different countries and a study carried out in a natural setting. Results indicated that our treatment was equally effective in both settings and that effectiveness was comparable to that achieved by the other studies in research and natural settings. Copyright © 2002 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Psychology & Psychotherapy is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PANIC disorders
KW - MENTAL illness
KW - THERAPEUTICS
KW - COGNITION
KW - BEHAVIOR
N1 - Accession Number: 11820429; García-Palacios, A. 1 Botella, C. 1 Robert, C. 2 Baños, R. 3 Perpiñá, C. 3 Quero, S. 1 Ballester, R. 1; Affiliation: 1: University Jaume I, Dpt. Basic and Clinical Psychology and Psychobiology, Castellón, Spain 2: Vila-real Public Mental Health Unit (Castellón), Public Health Service of Valencia, Spain 3: University of Valencia, Dpt. of Personality, Evaluation and Psychological Treatment, Valencia, Spain; Source Info: Nov/Dec2002, Vol. 9 Issue 6, p373; Subject Term: PANIC disorders; Subject Term: MENTAL illness; Subject Term: THERAPEUTICS; Subject Term: COGNITION; Subject Term: BEHAVIOR; Number of Pages: 11p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1002/cpp.337
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leikina, Eugenia
AU - Ramos, Corinne
AU - Markovic, Ingrid
AU - Zimmerberg, Joshua
AU - Chernomordik, Leonid V.
T1 - Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin.
JO - EMBO Journal
JF - EMBO Journal
Y1 - 2002/11//11/1/2002
VL - 21
IS - 21
M3 - Article
SP - 5701
EP - 5710
SN - 02614189
AB - The refolding of the prototypic fusogenic protein hemagglutinin (HA) at the pH of fusion is considered to be a concerted and irreversible discharge of a loaded spring, with no distinct intermediates between the initial and final conformations. Here, we show that HA refolding involves reversible conformations with a lifetime of minutes. After reneutralization, low pH-activated HA returns from the conformations wherein both the fusion peptide and the kinked loop of the IL&2 subunit are exposed, but the HA1 subunits have not yet dissociated, to a structure indistinguishable from the initial one in functional, biochemical and immunological characteristics. The rate of the transition from reversible conformations to irreversible refolding depends on the pH and on the presence of target membrane. Importantly, recovery of the initial conformation is blocked by the interactions between adjacent HA trimers. The existence of the identified reversible stage of refolding can be crucial for allowing multiple copies of HA to synchronize their release of conformational energy, as required for fusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - HEMAGGLUTININ
KW - PEPTIDES
KW - BIOLOGICAL membranes
KW - IMMUNOLOGY
KW - IMMUNITY
KW - influenza hemagglutinin
KW - membrane rearrangements
KW - protein interactions
KW - reversible change
KW - viral fusion
N1 - Accession Number: 12956202; Leikina, Eugenia 1 Ramos, Corinne 1 Markovic, Ingrid 2 Zimmerberg, Joshua 1 Chernomordik, Leonid V. 1; Email Address: lchern@helix.nih.gov; Affiliation: 1: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1855, USA. 2: Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.; Source Info: 11/1/2002, Vol. 21 Issue 21, p5701; Subject Term: PROTEINS; Subject Term: HEMAGGLUTININ; Subject Term: PEPTIDES; Subject Term: BIOLOGICAL membranes; Subject Term: IMMUNOLOGY; Subject Term: IMMUNITY; Author-Supplied Keyword: influenza hemagglutinin; Author-Supplied Keyword: membrane rearrangements; Author-Supplied Keyword: protein interactions; Author-Supplied Keyword: reversible change; Author-Supplied Keyword: viral fusion; Number of Pages: 10p; Document Type: Article
L3 - 10.1093/emboj/cdf559
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huffman, L. J.
AU - Prugh, D. J.
AU - Brumbaugh, K.
AU - Ding, M.
T1 - INFLUENCE OF HYPERTHYROIDISM ON RAT LUNG CYTOKINE PRODUCTION AND NUCLEAR FACTOR-κB ACTIVATION FOLLOWING OZONE EXPOSURE.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2002/11//
VL - 14
IS - 11
M3 - Article
SP - 1161
EP - 1174
PB - Taylor & Francis Ltd
SN - 08958378
AB - Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. To better understand the processes that might contribute to the increased pulmonary inflammatory response to ozone in hyperthyroidism, we evaluated bronchoalveolar lavage fluid levels of selected cytokines in control and hyperthyroid rats after exposure to air or ozone. In addition, we assessed whether there is a relative increase in nuclear factor-kappa B (NF-κB) binding activity in cells harvested by bronchoalveolar lavage from hyperthyroid rats following the inhalation of ozone. A hyperthyroid condition was induced by the administration of thyroxine (0.5 mg/kg body weight) for 7 days. Control rats received vehicle injections. The animals were then exposed by inhalation to air or ozone (2 ppm for 3 h) and studied 18 h following the exposure. Bronchoalveolar lavage levels of MIP-2 and MCP-1 were increased in both control and hyperthyroid rats by ozone exposure. However, the increases in hyperthyroid rats were much greater, MIP-2 1.5-fold and MCP-1 11-fold, when compared to levels in controls following ozone. These changes appeared to be relatively specific; bronchoalveolar lavage fluid levels of interleukin (IL)-6, IL-4, and IL-10 were generally low or nondetectable across all of the studied groups at the 18-h postexposure time point. We also found that NF-κB binding activity was increased at both 4 and 18 h following ozone exposure in bronchoalveolar lavage cell extracts from hyperthyroid rats relative to the activity in control samples. Collectively, these results suggest that mechanisms contributing to the enhanced pulmonary inflammatory response to ozone in a hyperthyroid state include an increase in NF-κB activation and an upregulation of chemokine production. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTHYROIDISM
KW - RATS
KW - CYTOKINES
KW - NF-kappa B (DNA-binding protein)
KW - OZONE
N1 - Accession Number: 8554561; Huffman, L. J. 1 Prugh, D. J. 2 Brumbaugh, K. 2 Ding, M. 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, and Department of Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Nov2002, Vol. 14 Issue 11, p1161; Subject Term: HYPERTHYROIDISM; Subject Term: RATS; Subject Term: CYTOKINES; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: OZONE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/08958370290084845
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8554561&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bernard, Didem
AU - Selden, Thomas M.
AD - Agency for Healthcare Research and Quality, Rockville, MD
AD - Agency for Healthcare Research and Quality, Rockville, MD
T1 - Employer Offers, Private Coverage, and the Tax Subsidy for Health Insurance: 1987 and 1996
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2002/11//
VL - 2
IS - 4
SP - 297
EP - 318
SN - 13896563
N1 - Accession Number: 0800870; Keywords: Health Insurance; Health; Subsidies; Subsidy; Tax; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200511
N2 - Economists have long been interested in the effect of tax-based subsidies on private health insurance coverage. We examine this relationship using pooled data from the 1987 National Medical Expenditure Survey and the 1996 Medical Expenditure Panel Survey. Our main tax price elasticity estimates for employer offers and for private coverage are near the mid-point of the existing literature. However, these estimates may mask substantial differences in tax-price responsiveness across subsets of workers. Our more disaggregated analysis reveals tax price responsiveness to be significantly above average for low-income workers, workers with low health risks, and workers in small firms--precisely those groups whose continued participation in employment-related risk pooling is of greatest policy concern. In addition, we present family-level elasticities that allow for joint decision-making in two-worker families.
KW - Personal Income and Other Nonbusiness Taxes and Subsidies; includes inheritance and gift taxes H24
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
KW - Personnel Economics: Compensation and Compensation Methods and Their Effects M52
L3 - http://link.springer.com/journal/volumesAndIssues/10754
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UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Curwin, B.
AU - Sanderson, W.
AU - Reynolds, S.
AU - Hein, M.
AU - Alavanja, M.
T1 - Pesticide Use and Practices in an Iowa Farm Family Pesticide Exposure Study.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2002/11//
VL - 8
IS - 4
M3 - Article
SP - 423
EP - 433
SN - 10747583
AB - Discuses results of a study which investigated differences in pesticide contamination and exposure factors between 25 farm homes and 25 non-farm homes. Number of houses using residential pesticides in the home, on the lawn and in the garden; Crop and pesticide spraying demographics; Active ingredients applied by farmers to corn and soybeans.
KW - Air pollution
KW - Pesticides
KW - Farmhouses
N1 - Accession Number: 10814226; Curwin, B.; Email Address: bcurwin@cdc.gov; Sanderson, W. 1; Reynolds, S. 2; Hein, M. 3; Alavanja, M. 4; Affiliations: 1: Department of Occupational and Environmental Health, University of Iowa; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Department of Environmental Health, Colorado State University, Fort Collins, Colorado; 4: National Cancer Institute, Bethesda, Maryland; Issue Info: Nov2002, Vol. 8 Issue 4, p423; Thesaurus Term: Air pollution; Thesaurus Term: Pesticides; Subject Term: Farmhouses; NAICS/Industry Codes: 236110 Residential building construction; NAICS/Industry Codes: 236115 New Single-Family Housing Construction (except For-Sale Builders); NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 11p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106827259
T1 - Persistent organic pollutants exposure assessment using the US Total Diet Study.
AU - Bolger PM
AU - Egan K
AU - Jensen E
AU - Canady R
Y1 - 2002/11//
N1 - Accession Number: 106827259. Language: English. Entry Date: 20030502. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Schafer KS, Kegley SE, Porta M, Zumeta E. Persistent toxic chemicals in the US food supply. (J EPIDEMIOL COMMUNITY HEALTH) Nov2002; 56 (11): 813-817. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766.
KW - Food Contamination -- Analysis
KW - Pesticides -- Analysis
KW - United States
KW - Diet
KW - Environmental Pollutants -- Administration and Dosage
KW - Environmental Pollutants -- Analysis
SP - 818
EP - 819
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
JA - J EPIDEMIOL COMMUNITY HEALTH
VL - 56
IS - 11
PB - BMJ Publishing Group
AB - The assessment presented in the core paper of this debate by Schafer and Kegley does not adequately describe the computational methodology or sources of data that were used to estimate exposures. While it is difficult to determine from the article, the exposure estimates seem to be very dependent on action levels, rather than on empirically derived data. There is no adequate presentation of analytical methods, limits of detection, or the significance of non-detects in deriving estimates of exposure.
SN - 0143-005X
AD - Director, Division of Risk Assessment, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835; Philip.Bolger@cfsan.fda.gov
U2 - PMID: 12388567.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106827827
T1 - Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood.
AU - Chaisavaneeyakorn S
AU - Moore JM
AU - Othoro C
AU - Otieno J
AU - Chaiyaroj SC
AU - Shi YP
AU - Nahlen BL
AU - Lal AA
AU - Udhayakumar V
Y1 - 2002/11//11/1/2002
N1 - Accession Number: 106827827. Language: English. Entry Date: 20030502. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Supported by the Medical Scholars Program of Mahidol University; US Agency for International Development (grants A0T0483-PH1-2171 and HRN-A-00-04-00010-02); United Nations Development Program/World Bank/World Health Organization Special Program for Research and Training in Tropical Diseases (grant 960568); by a research grant from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grant 1 RO1 AI50240-01), and by a Thailand Research Fund Fellowship. NLM UID: 0413675.
KW - Malaria -- Immunology -- In Pregnancy
KW - Immunity, Maternally Acquired
KW - Malaria -- Immunology
KW - Macrophages
KW - Fetal Blood -- Immunology
KW - Pregnancy
KW - HIV Infections -- In Pregnancy
KW - Enzyme-Linked Immunosorbent Assay
KW - Wilcoxon Rank Sum Test
KW - Kruskal-Wallis Test
KW - Data Analysis Software
KW - Female
KW - Funding Source
KW - Human
SP - 1371
EP - 1375
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 186
IS - 9
PB - Oxford University Press / USA
AB - Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids. The present study investigated whether plasma MIF levels are altered in pregnant women with placental malaria (PM) and/or human immunodeficiency virus (HIV) infection. For the first time it is demonstrated that MIF levels in the intervillous blood (IVB) plasma were significantly elevated, compared with that in both peripheral plasma ( approximately 500-fold) and cord plasma (4.6-fold; P<.01). IVB mononuclear cells also produced significantly higher levels of MIF, compared with that of peripheral blood mononuclear cells. PM was associated with increased levels of MIF in the IVB plasma (P<.02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P<.05). HIV infection did not significantly alter MIF levels in any site examined. Copyright © 2002 Infectious Diseases Society of America
SN - 0022-1899
AD - Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, GA
U2 - PMID: 12402212.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106826323
T1 - Ectopic pregnancy risk when contraception fails: a review.
AU - Furlong L
Y1 - 2002/11//2002 Nov
N1 - Accession Number: 106826323. Language: English. Entry Date: 20030425. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0173343.
KW - Pregnancy, Ectopic -- Etiology
KW - Contraceptive Agents -- Adverse Effects
KW - United States Food and Drug Administration
KW - Contraceptive Devices -- Adverse Effects
KW - Pregnancy
KW - Female
SP - 881
EP - 885
JO - Journal of Reproductive Medicine
JF - Journal of Reproductive Medicine
JA - J REPROD MED
VL - 47
IS - 11
CY - St. Louis, Missouri
PB - Journal of Reproductive Medicine
AB - OBJECTIVE: To alert clinicians to the risk of ectopic pregnancy when certain contraceptive methods fail by summarizing data from trials reviewed by the U.S. Food and Drug Administration (FDA). STUDY DESIGN: The review focuses on 7 contraceptive drug products with an increased risk of ectopic pregnancy when the method fails. Data were extracted from reviews of clinical trials submitted to the FDA to support marketing applications and from the medical literature. Data on 6 other contraceptive drug products and published data for tubal ligations are used for comparison. This review does not include medroxyprogesterone acetate injections because the FDA reviews for this method did not include any pregnancy outcome information. RESULTS: The results are presented in a table and are compared to postmarketing surveillance reports and published literature, when available. The proportion of ectopic pregnancies among all pregnancies ranged from 1:2 to 1:21 for intrauterine devices, tubal ligations, progestin-only implants and progestin-only oral contraceptives. Although the confidence intervals for the proportions were large in trials with few pregnancies, both postmarketing surveillance reports and published literature support proportions calculated from clinical trial data. CONCLUSION: Pregnancies in women using progestin-only oral contraceptives, progestin-only implants, intrauterine devices and tubal ligations are more likely to be ectopic than pregnancies in the general population.
SN - 0024-7758
AD - U.S. Food and Drug Administration, HFD-580, 5600 Fishers Lane, Rockville, MD 20857; furlongl@cder.fda.gov
U2 - PMID: 12497674.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Papaconstantinou, Andriana D.
AU - Umbreit, Thomas H.
AU - Goering, Peter L.
AU - Brown, Ken M.
T1 - Effects of 17α-methyltestosterone on uterine morphology and heat shock protein expression are mediated through estrogen and androgen receptors
JO - Journal of Steroid Biochemistry & Molecular Biology
JF - Journal of Steroid Biochemistry & Molecular Biology
Y1 - 2002/11//
VL - 82
IS - 4/5
M3 - Article
SP - 305
SN - 09600760
AB - Testosterone and the synthetic androgen, 17α-methyltestosterone (MT), have been shown to increase uterine weights and alter uterine morphology. However, whereas the mechanism of action of testosterone in the uterus has been studied, it is not known if the actions of MT are mediated through androgen (AR) or estrogen (ER) receptors. In the present study, we have shown that MT, at 0.5 or 10 mg/kg per day, increases uterine weight and alters uterine morphology in a dose-dependent manner. Co-administration of the anti-androgen, flutamide, or the anti-estrogen, ICI 182,780, with MT revealed that the effects of the low dose of MT are mediated through the ER, whereas those of the high dose are mediated through both the ER and AR. In addition, we have studied the effects of MT on uterine heat shock proteins (hsps), a group of estrogen-regulated proteins whose levels increase in response to growth signals and protein damage. MT increased levels of hsp90α, hsp72, and grp94. All effects on uterine hsp levels were antagonized by the anti-estrogen and not the anti-androgen. Collectively, the results of the present study indicate that the effects of MT in the uterus are mediated through the AR and ER. [Copyright &y& Elsevier]
AB - Copyright of Journal of Steroid Biochemistry & Molecular Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROGENS
KW - UTERUS
KW - 17α-Methyltestosterone
KW - Androgen
KW - Anti-estrogen
KW - Flutamide
KW - grp94
KW - Heat shock proteins
KW - hsp72
KW - Hsp90α
KW - Uterotrophism
N1 - Accession Number: 9051027; Papaconstantinou, Andriana D. 1 Umbreit, Thomas H. 2 Goering, Peter L. 2 Brown, Ken M. 1; Email Address: kmb@gwu.edu; Affiliation: 1: Department of Biological Sciences, George Washington University, 332 Lisner Hall, 2023 G. St. N.W., Washington, DC 20052, USA 2: Center for Devices and Radiological Health, Food and Drug Administration, 12709 Twinbrook Parkway, HFZ-112, Rockville, MD 20857, USA; Source Info: Nov2002, Vol. 82 Issue 4/5, p305; Subject Term: ANDROGENS; Subject Term: UTERUS; Author-Supplied Keyword: 17α-Methyltestosterone; Author-Supplied Keyword: Androgen; Author-Supplied Keyword: Anti-estrogen; Author-Supplied Keyword: Flutamide; Author-Supplied Keyword: grp94; Author-Supplied Keyword: Heat shock proteins; Author-Supplied Keyword: hsp72; Author-Supplied Keyword: Hsp90α; Author-Supplied Keyword: Uterotrophism; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang, I.
AU - Beard, B.
T1 - Precision test apparatus for evaluating the heating pattern of radiofrequency ablation devices
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
Y1 - 2002/11//
VL - 24
IS - 9
M3 - Article
SP - 633
SN - 13504533
AB - Radiofrequency has established itself as a useful technique for managing cardiac arrhythmias and treating soft tissue tumors. However, despite its pervasive use, many of the biophysical principals needed to fully understand and optimize the radiofrequency ablation technique have not been explored. We have designed a test rig that is useful for studying the heat transfer mechanisms that affect the outcome of radiofrequency ablation devices. Using both solid and liquid phantom materials, which simulate body tissues and blood, the test rig is designed for systematic testing of the effects of predictable flow patterns on the temperature profiles generated within the solid phantom.The test rig consists of a custom built thermistor array, a linear test chamber, and a radiofrequency generator. We calibrate the flow of a liquid phantom material to demonstrate that predictable laminar flow profiles are generated. To demonstrate the performance of the ablation system, we present preliminary data attained using a commercially available cardiac ablation catheter.The advantages of this test system are its flexibility, its reproducibility, its precision, and its low cost. Thus, it is ideally suited for studying a variety of complex ablation problems involving multiple tissues types and complex blood flow geometries. [Copyright &y& Elsevier]
AB - Copyright of Medical Engineering & Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIO frequency
KW - ARRHYTHMIA
KW - SOFT tissue tumors
KW - TREATMENT
KW - Measurement techniques
KW - Radiofrequency ablation
N1 - Accession Number: 7889599; Chang, I.; Email Address: iac@cdrh.fda.gov Beard, B. 1; Affiliation: 1: US Food and Drug Administration, 12725 Twinbrook Parkway (HFZ-133), Rockville, MD 20852, USA; Source Info: Nov2002, Vol. 24 Issue 9, p633; Subject Term: RADIO frequency; Subject Term: ARRHYTHMIA; Subject Term: SOFT tissue tumors; Subject Term: TREATMENT; Author-Supplied Keyword: Measurement techniques; Author-Supplied Keyword: Radiofrequency ablation; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bada, Henrietta S.
AU - Das, Abhik
AU - Bauer, Charles R.
AU - Shankaran, Seetha
AU - Lester, Barry
AU - Wright, Linda L.
AU - Verter, Joel
AU - Smeriglio, Vincent L.
AU - Finnegan, Loretta P.
AU - Maza, Penelope L.
T1 - Gestational cocaine exposure and intrauterine growth: maternal lifestyle study
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2002/11//
VL - 100
IS - 5 part 1
M3 - Article
SP - 916
SN - 00297844
AB - OBJECTIVE:To estimate the effects of cocaine exposure on intrauterine growth and to investigate at what point in gestation growth deviation would be manifested.METHODS:This is a secondary analysis of data from a multicenter project, the Maternal Lifestyle Study, designed to determine infant outcomes of in utero cocaine or opiates exposure. Four centers of the National Institute of Child Health and Human Development Neonatal Research Network enrolled 11,811 maternal-infant dyads. A total of 1072 infants were cocaine exposed, 7565 were cocaine negative by maternal history and meconium results, and 3174 were excluded from analysis because of unconfirmed negative exposure. Outcome measures included birth weight, length, and head circumference.RESULTS:Percentile estimates for birth weight, length, and head circumference revealed growth deceleration in cocaine-exposed infants evident after 32 weeks’ gestation. There was significant interaction between cocaine and gestational age. After controlling for confounders, at 40 weeks’ gestation, cocaine exposure was estimated to be associated with a decrease of 151 g, 0.71 cm, and 0.43 cm in birth weight, length, and head circumference, respectively. Smoking had a negative impact on all growth measurements, with some indication of a dose-effect relationship. Heavy alcohol use was associated with decrease in weight and length only. Opiates had significant effect only on birth weight.CONCLUSION:In utero cocaine exposure is associated with growth deceleration involving all measurements, becoming more pronounced with advancing gestation. [Copyright &y& Elsevier]
AB - Copyright of Obstetrics & Gynecology is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCAINE
KW - PREGNANCY
N1 - Accession Number: 8784080; Bada, Henrietta S. 1; Email Address: hbada2@uky.edu Das, Abhik 2 Bauer, Charles R. 3 Shankaran, Seetha 4 Lester, Barry 5 Wright, Linda L. 6 Verter, Joel 7 Smeriglio, Vincent L. 8 Finnegan, Loretta P. 9 Maza, Penelope L. 10; Affiliation: 1: The University of Kentucky, Lexington, Kentucky, USA 2: Research Triangle Institute, Research Triangle Park, North Carolina, USA 3: University of Miami, Miami, Florida, USA 4: Wayne State University, Detroit, Michigan, USA 5: Brown University, Providence, Rhode Island, USA 6: National Institute of Child Health and Human Development, Bethesda, Maryland, USA 7: George Washington University, Washington, DC, USA 8: National Institute on Drug Abuse, Bethesda, Maryland, USA 9: Center for Substance Abuse Treatment, Rockville, Maryland, USA 10: Administration for Children, Youth and Families, Washington, DC, USA; Source Info: Nov2002, Vol. 100 Issue 5 part 1, p916; Subject Term: COCAINE; Subject Term: PREGNANCY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106822390
T1 - FDA drug approval summaries: fulvestrant.
AU - Bross PF
AU - Cohen MH
AU - Williams GA
AU - Pazdur R
Y1 - 2002/11//
N1 - Accession Number: 106822390. Language: English. Entry Date: 20030411. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Breast Neoplasms -- Drug Therapy
KW - Antineoplastic Agents, Hormonal -- Therapeutic Use
KW - Estradiol -- Analogs and Derivatives
KW - Treatment Outcomes
KW - United States Food and Drug Administration
KW - Postmenopause
KW - Neoplasm Metastasis
KW - Human
SP - 477
EP - 480
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 7
IS - 6
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Patients with hormone-sensitive breast cancer who have responded to tamoxifen may receive additional benefit from a second endocrine agent following progression or relapse after tamoxifen therapy. Fulvestrant (Faslodex((R)), ICI 182780, AstraZeneca Pharmaceuticals; Wilmington, Delaware) is a selective antagonist of estrogen designed to have no estrogenic effects. Lack of aqueous solubility led to the development of a parenteral formulation for monthly intramuscular administration. Fulvestrant has been shown to inhibit the proliferative effects of estrogen on sensitive tissues in vitro and in vivo, and is without apparent measurable estrogenic activity. The data upon which marketing approval for fulvestrant was based are summarized below. Eight hundred fifty-one postmenopausal women with advanced breast cancer were enrolled in two phase III studies, 400 in a North American double-blind study and 451 in a European open-label study, comparing the efficacy and safety of fulvestrant with anastrozole. Four hundred twenty-eight patients were randomized to receive fulvestrant 250 mg monthly by intramuscular injection and 423 patients were to receive anastrozole 1 mg daily. Patients were considered hormone sensitive either by receptor status or previous response to endocrine therapy. Over 96% of patients had previously received tamoxifen, either in the adjuvant setting or as treatment for metastatic disease. The primary study end points were response rate and time to progression. Response rates for patients treated with fulvestrant were 17% and 20% in the North American and European trials, respectively, compared with 17% and 15% in the anastrozole treatment arms. There were no statistically significant differences in response rates, time to progression, or survival between treatment arms in either study. The most common adverse events attributed to the treatment (>10%) were injection-site reactions and hot flashes. Common events (1%-10%) included asthenia, headache, and gastrointestinal disturbances (nausea, vomiting, and diarrhea), as well as rash and urinary tract infections. A small increase in joint disorders was reported in the anastrozole-treated patients. On April 25, 2002, fulvestrant 250 mg by monthly intramuscular injection was approved by the U.S. Food and Drug Administration for the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy. Approval was based on similarity of response rates and time to progression between fulvestrant and anastrozole.
SN - 1083-7159
AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, HFD-150, 5600 Fishers Lane, Rockville, Maryland 20857; brossp@cder.fda.gov
U2 - PMID: 12490735.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106812616
T1 - Bringing new nebulizer technologies to market: regulatory issues.
AU - Meyer RJ
Y1 - 2002/11//2002 Nov
N1 - Accession Number: 106812616. Language: English. Entry Date: 20030307. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7510357.
KW - Nebulizers and Vaporizers
KW - Government Regulations -- United States
KW - United States Food and Drug Administration
KW - United States
KW - World Wide Web
KW - Information Resources
SP - 1334
EP - 1336
JO - Respiratory Care
JF - Respiratory Care
JA - RESPIR CARE
VL - 47
IS - 11
CY - Irving, Texas
PB - Daedalus Enterprises, Inc.
AB - This review outlines regulatory issues involved in bringing new nebulizer technologies to market and describes the regulatory roles of the Center for Devices and Radiologic Health and the Center for Drug Evaluation and Research. The responsible agency is determined by whether a new device involves a new drug formulation.
SN - 0020-1324
AD - Office of Drug Evaluation II, HFD-102, Center for Drug Evaluation and Research, United States Food and Drug Administration, Parklawn Bldg, 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 12425748.
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DB - rzh
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Jernigan, Michael R.
AU - Ma, Jane Y. C.
AU - Clarke, Robert W.
AU - Hui-Min Yang
T1 - Residual Oil Fly Ash Increases the Susceptibility to Infection and Severely Damages the Lungs after Pulmonary Challenge with a Bacterial Pathogen.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/11//
VL - 70
IS - 1
M3 - Article
SP - 110
EP - 119
PB - Oxford University Press / USA
SN - 10966080
AB - Inhalation of residual oil fly ash (ROFA), a component of ambient particulate matter, has been shown to increase pulmonary morbidity and impair lung defense mechanisms in exposed workers. Our objective was to evaluate the effect of ROFA preexposure on lung defense and injury after pulmonary challenge with a bacterial pathogen. Male Sprague-Dawley rats were dosed intratracheally at day 0 with saline (control) or ROFA (0.2 or 1 mg/100 g body weight). Three days later, a low (5 × 103) or high (5 × 105) dose of Listeria monocytogenes was instilled intratracheally into the ROFA- and saline-treated rats. Bronchoalveolar lavage was performed on the right lungs at days 6, 8, and 10. The recovered cells were differentiated, and chemiluminescence (CL) and nitric oxide (NO) production, two indices of alveolar macrophage (AM) function, were measured. At the same time points, the left lung and spleen were removed, homogenized, and cultured, and colony-forming units were counted after an overnight incubation. Exposure to ROFA and the high dose of L. monocytogenes led to marked lung injury and inflammation as well as to an increase in mortality, compared with rats treated with saline and the high dose of L. monocytogenes. Preexposure to ROFA significantly enhanced injury and delayed the pulmonary clearance of L. monocytogenes at both bacterial doses when compared to the saline-treated control rats. ROFA had no effect on AM CL but caused a significant suppression of AM NO production, as compared to the saline control rats. We have demonstrated that acute exposure to ROFA slowed the pulmonary clearance of L. monocytogenes. The suppression in AM NO production by ROFA pretreatment likely plays an important role. These results suggest that pulmonary exposure to ROFA may alter AM function and lead to increased susceptibility to lung infection in exposed populations. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fly ash
KW - Oil saturation in reservoirs
KW - Particulate matter
KW - Air quality
KW - Poisonous gases -- Toxicology
KW - Lung diseases
KW - chemiluminescence
KW - Listeria monocytogenes
KW - macrophage
KW - pulmonary clearance
KW - residual oil fly ash
N1 - Accession Number: 44406430; Antonini, James M. 1; Email Address: jga6@cdc.gov; Roberts, Jenny R. 1; Jernigan, Michael R. 1; Ma, Jane Y. C. 1; Clarke, Robert W. 2; Hui-Min Yang 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2015, Morgantown, West Virginia 26505; 2: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115; Issue Info: Nov2002, Vol. 70 Issue 1, p110; Thesaurus Term: Fly ash; Thesaurus Term: Oil saturation in reservoirs; Thesaurus Term: Particulate matter; Thesaurus Term: Air quality; Thesaurus Term: Poisonous gases -- Toxicology; Subject Term: Lung diseases; Author-Supplied Keyword: chemiluminescence; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: macrophage; Author-Supplied Keyword: pulmonary clearance; Author-Supplied Keyword: residual oil fly ash; Number of Pages: 10p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
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ER -
TY - JOUR
AU - Tsuyuki, Shigeru
AU - Kono, Mari
AU - Bloom, Eda T
T1 - Cloning and potential utility of porcine Fas ligand: overexpression in porcine endothelial cells protects them from attack by human cytolytic cells.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2002/11//
VL - 9
IS - 6
M3 - Article
SP - 410
EP - 421
PB - Wiley-Blackwell
SN - 0908665X
AB - Tsuyuki S, Kono M, Bloom ET. Cloning and potential utility of porcine Fas ligand: overexpression in porcine endothelial cells protects them from attack by human cytolytic cells. Xenotransplantation 2002; 9:410–421. © Blackwell Munksgaard, 2002 Endothelial cells (EC) are primary targets of the recipient's immune response to transplanted organs and constitutively express Fas (CD95) ligand (FasL) on their surface. We investigated the role of porcine FasL in the generation of the human anti-pig response in vitro. Porcine aortic endothelial cells (PAEC) lysed a Fas+ human T-cell line, Jurkat. Anti-human Fas monoclonal antibody (mAb) specifically inhibited this killing in a dose-dependent manner, suggesting that porcine FasL recognizes and binds human Fas to induce apoptosis of human Fas+ cells. We next cloned porcine FasL, identifying an open reading frame of 849 base pairs predicting a protein of 282 amino acids. The predicted amino acid sequence was 85, 76, and 75% homologous to the predicted amino acid sequences of human, mouse, and rat, respectively, and found that PAEC expressed both FasL mRNA and protein. Transient transfection was used to increase or induce porcine FasL expression in PAEC or COS-7 cells. Transfection of PAEC with a plasmid encoding porcine FasL increased their ability to induce apoptosis in Jurkat cells, fresh human T cells activated with IL-2 and anti-CD3, and fresh IL-2-activated human (natural killer) NK cells. Moreover, porcine Fas L-transfected COS-7 cells induced significant apoptosis in Jurkat cells compared with that induced by mock-transfected COS-7 cells. Finally, the overexpression of porcine FasL in PAEC reduced their susceptibility as target cells to lysis by activated human NK or T cells. These findings suggest that porcine FasL overexpression in EC of vascularized xenografts may provide protection from cellular xenograft rejection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenotransplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIGANDS (Biochemistry)
KW - CLONING
KW - cell surface molecules
KW - cytotoxicity
KW - endothelial cells
KW - T cells
KW - transplantation
N1 - Accession Number: 7494996; Tsuyuki, Shigeru 1 Kono, Mari 2 Bloom, Eda T 1; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, 2: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: Nov2002, Vol. 9 Issue 6, p410; Subject Term: LIGANDS (Biochemistry); Subject Term: CLONING; Author-Supplied Keyword: cell surface molecules; Author-Supplied Keyword: cytotoxicity; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: T cells; Author-Supplied Keyword: transplantation; Number of Pages: 12p; Document Type: Article
L3 - 10.1034/j.1399-3089.2002.01114.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2003-02686-006
AN - 2003-02686-006
AU - Clancy, Carolyn
AU - Stryer, Daniel
AU - Eisenberg, John M.
T1 - From Publication to Public Action: Agency for Healthcare Research and Quality (AHRQ) Perspectives on Ethnicity and Race-related Outcomes Research.
JF - Ethnicity & Health
JO - Ethnicity & Health
JA - Ethn Health
Y1 - 2002/11//
VL - 7
IS - 4
SP - 287
EP - 290
CY - United Kingdom
PB - Taylor & Francis
SN - 1355-7858
SN - 1465-3419
AD - Clancy, Carolyn, Agency for Healthcare Research and Quality, Immediate Office of the Director, 2101 E. Jefferson Ave., Suite 600, Rockville, MD, US, 20852
N1 - Accession Number: 2003-02686-006. PMID: 12772548 Partial author list: First Author & Affiliation: Clancy, Carolyn; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20040217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Race and Ethnic Discrimination; Treatment Effectiveness Evaluation; Quality of Services; Agency. Classification: Research Methods & Experimental Design (2260); Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 4. Issue Publication Date: Nov, 2002.
AB - The article discusses the perspectives of Agency for Healthcare Research and Quality (AHRQ) on ethnicity and race related outcomes research. Examining the contributions of recent research on the outcomes of health care associated with race and ethnicity coincides with international recognition of the importance of inequalities in health and health care. The work presented in this issue as well as other research by the Centers for Medical Treatment Effectiveness in Diverse Populations (MEDTEP Centers) represents many contributions to minority health and our knowledge of racial and ethnic disparities in health care. The MEDTEP program has made inroads into three components of disparities research: documentation of their existence, understanding of their causes and contributing factors, and identification of ways in which to eliminate them. The completion of the MEDTEP program represents both an end that should be celebrated as well as part of a much longer process that will require sustained energy, resources and innovation. We must identify the differences and analyze the contributing factors at the levels of appropriateness, patient preferences, operation of the health care system and clinical encounters. Also effective interventions and inequities should be identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care inequality
KW - Medical Treatment Effectiveness in Diverse Populations
KW - racial and ethnic disparity
KW - health care disparity
KW - Agency for Healthcare Research and Quality
KW - outcomes research
KW - 2002
KW - Experimentation
KW - Race and Ethnic Discrimination
KW - Treatment Effectiveness Evaluation
KW - Quality of Services
KW - Agency
KW - 2002
DO - 10.1080/1355785022000060745
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UR - cclancy@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106818404
T1 - Clinical informatics and patient safety at the Agency for Healthcare Research and Quality...reprinted from the proceedings of the 2001 AMIA Annual Symposium, with permission
AU - Ortiz E
AU - Meyer G
AU - Burstin H
Y1 - 2002/11/02/2002 Supplement
N1 - Accession Number: 106818404. Language: English. Entry Date: 20030328. Revision Date: 20150820. Publication Type: Journal Article. Supplement Title: 2002 Supplement. Journal Subset: Blind Peer Reviewed; Computer/Information Science; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9430800.
KW - Patient Safety
KW - United States Agency for Healthcare Research and Quality
KW - Health Informatics
KW - Research Priorities
SP - S2
EP - 7
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
JA - J AM MED INFORM ASSOC
VL - 9
PB - Oxford University Press / USA
AB - In 1998, the Institute of Medicine (IOM) issued a report on medical errors, which estimated that up to 98,000 people die in U.S. hospitals each year from errors. This report raised concerns that medical errors have become a national public health problem that should be addressed in the same manner as other epidemics such as heart disease, diabetes, and obesity. In 2001, the IOM released a follow-up report encompassing a broader range of quality issues. They concluded that the U.S. healthcare system is outmoded and incapable of providing consistent, high-quality care. They outlined a strategy for redesigning U.S. healthcare delivery to achieve safe, dependable, high-quality care, which emphasizes information technology as an integral part of the solution. AHRQ's fiscal year 2001 appropriation included $50 million dollars for initiatives to reduce medical errors and improve patient safety. AHRQ responded to this mandate by developing a series of research solicitations that form an integrated set of activities to design and test best practices for reducing errors in multiple health care settings. This paper discusses the components of this program and the central role of medical informatics research in the Agency's efforts to improve the safety of medical care in America.
SN - 1067-5027
AD - Agency for Healthcare Research and Quality, Rockville, MD
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DB - rzh
ER -
TY - JOUR
AU - Von Tungeln, Linda S.
AU - Yi, Ping
AU - Bucci, Thomas J.
AU - Samokyszyn, Victor M.
AU - Chou, Ming W.
AU - Kadlubar, Fred F.
AU - Fu, Peter P.
T1 - Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F1 neonatal mouse
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/11/08/
VL - 185
IS - 1
M3 - journal article
SP - 13
EP - 19
SN - 03043835
AB - The tumorigenicity of chloral hydrate (CH), trichloroacetic acid (TCA), trichloroethanol (TCE), malondialdehyde (MDA), crotonaldehyde, acrolein, and 4-hydroxy-2-nonenal (HNE) was tested in the B6C3F1 neonatal mouse. Mice were administered i.p. injections of CH (1000, 2000, 2500, and 5000 nmol per animal), TCA (1000 and 2000 nmol), TCE (1000 and 2000 nmol), MDA (1500 and 3000 nmol), crotonaldehyde (1500 and 3000 nmol), acrolein (75 and 150 nmol), and HNE (750 and 1500 nmol) at 8 and 15 days of age. At 12 months, only male mice treated with the positive control chemicals, 4-aminobiphenyl (500 and 1000 nmol) and benzo[a]pyrene (150 and 300 nmol), had incidences of tumors in the liver significantly higher than the solvent control. Additional male mice were dosed as described above and their livers were excised at 24, 48 h, and 7 days after the final dose. Liver DNA was isolated and analyzed by 32P-postlabeling/high-performance liquid chromatography (HPLC) and HPLC/electrochemical detection for MDA-derived adduct (M1G) and 8-oxo-2′-deoxyguanosine (8-OHdG) formation, respectively. At 24 and 48 h after the final dose, CH- and TCA-treated mice exhibited significantly higher M1G levels than the controls. 8-OHdG formation was also induced by CH, TCA, and MDA. These results suggest that under these experimental conditions the B6C3F1 neonatal mouse is not sensitive to carcinogens that induce an increase in endogenous DNA adduct formation through lipid peroxidation or oxidative stress. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDRATES
KW - CARCINOGENESIS
KW - Chloral hydrate
KW - Lipid peroxidation
KW - Neonatal B6C3F1 mouse
N1 - Accession Number: 7852053; Von Tungeln, Linda S. 1 Yi, Ping 1 Bucci, Thomas J. 2 Samokyszyn, Victor M. 3 Chou, Ming W. 1 Kadlubar, Fred F. 1 Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Pathology Associates International, Inc., National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Source Info: Nov2002, Vol. 185 Issue 1, p13; Subject Term: HYDRATES; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: Chloral hydrate; Author-Supplied Keyword: Lipid peroxidation; Author-Supplied Keyword: Neonatal B6C3F1 mouse; Number of Pages: 7p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Collins, Jerry M.
T1 - Idiosyncratic drug toxicity
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2002/11/10/
VL - 142
IS - 1/2
M3 - Editorial
SP - 3
SN - 00092797
N1 - Accession Number: 7906263; Collins, Jerry M. 1; Email Address: collinsj@cder.fda.gov; Affiliation: 1: Laboratory of Clinical Pharmacology, Food and Drug Administration/CDER, HFD-902/NLRC, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: Nov2002, Vol. 142 Issue 1/2, p3; Number of Pages: 4p; Document Type: Editorial
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DB - aph
ER -
TY - JOUR
AU - Hartman, Neil R.
AU - Cysyk, Richard L.
AU - Bruneau-Wack, Claudine
AU - Thénot, Jean-Paul
AU - Parker, Robert J.
AU - Strong, John M.
T1 - Production of intracellular 35S-glutathione by rat and human hepatocytes for the quantification of xenobiotic reactive intermediates
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2002/11/10/
VL - 142
IS - 1/2
M3 - Article
SP - 43
SN - 00092797
AB - The quantification and identification of xenobiotic reactive intermediates is difficult in the absence of highly radiolabeled drug. We have developed a method for identifying these intermediates by measuring the formation of adducts to intracellularly generated radiolabeled glutathione (GSH). Freshly isolated adherent rat and human hepatocytes were incubated overnight in methionine and cystine-free (‘thio-free’) medium. They were then exposed to 100 μM methionine and 10 μCi 35S-labeled methionine in otherwise thio-free medium to replete cellular GSH pools with intracellularly generated 35S-labeled GSH. After 3 h, acetaminophen was added as a test compound and the cells were incubated for an additional 24 h. Intracellular GSH and its specific activity were quantified after reaction with monobromobimane followed by HPLC analysis with fluorescence and radiochemical detection. Radiolabeled GSH was detectable at 3 h and maintained high specific activity and physiological concentrations for up to 24 h. Incubation medium from acetaminophen treated and nontreated hepatocytes were analyzed for radiolabeled peaks by HPLC using radiochemical detection. Radiolabeled peaks not present in nontreated hepatocytes were identified as acetaminophen GSH adducts by LC-MS. Formation of acetaminophen 35S-GSH adducts by rat hepatocytes containing endogenously synthesized 35S-GSH was increased with acetaminophen concentrations ranging from 500 to 2 mM. [Copyright &y& Elsevier]
AB - Copyright of Chemico-Biological Interactions is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - XENOBIOTICS
KW - INTERMEDIATES (Chemistry)
KW - GLUTATHIONE
KW - Acetaminophen
KW - Adducts
KW - Glutathione
KW - Hepatocytes
KW - Metabolism
KW - Reactive intermediates
N1 - Accession Number: 7906267; Hartman, Neil R. 1 Cysyk, Richard L. 2 Bruneau-Wack, Claudine 3 Thénot, Jean-Paul 3 Parker, Robert J. 1 Strong, John M. 1; Email Address: strongj@cder.fda.gov; Affiliation: 1: Laboratory of Clinical Pharmacology, Office of Testing and Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Laurel, MD, USA 2: Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 3: Pharmacokinetic and Metabolism, Sanofi Synthélabo Recherche, 91380 Chilly-Mazarin, France; Source Info: Nov2002, Vol. 142 Issue 1/2, p43; Subject Term: XENOBIOTICS; Subject Term: INTERMEDIATES (Chemistry); Subject Term: GLUTATHIONE; Author-Supplied Keyword: Acetaminophen; Author-Supplied Keyword: Adducts; Author-Supplied Keyword: Glutathione; Author-Supplied Keyword: Hepatocytes; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Reactive intermediates; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhu, Peixuan
AU - Tsai, Chao-Ming
AU - Frasch, Carl E.
T1 - Immunologic and genetic characterization of lipooligosaccharide variants in a Neisseria meningitidis serogroup C strain
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2002/11/15/
VL - 34
IS - 3
M3 - Article
SP - 193
SN - 09288244
AB - Neisseria meningitidis shows great variation in expression of structurally different lipooligosaccharides (LOS) on its cell surface. To better understand the LOS diversity that may occur within an individual strain, a group C wild-type strain, BB305-Tr4, and two stable isogenic LOS variants, Tr5 and Tr7, were selected for this study. SDS–PAGE analysis showed a size reduction of Tr5 and Tr7 LOS compared to that of Tr4. Immunoblotting showed that parental Tr4 LOS reacted with L1, L2 and L3,7 antibodies, variant Tr5 LOS with L1 and L6 antibodies, while Tr7 LOS was non-typeable. Genetic analysis showed that the gene organization at the lgt-1 locus in the three strains was lgtZ,C,A,B,H4 in Tr4, lgtZ,C,A,H4 in Tr5 and lgtZ,C,A,H9 in Tr7. The genetic differences in the three strains were consistent with their phenotypic changes. Sequence comparison revealed two independent recombination events. The first was the recombination of repeated DNA fragments in the flanking regions to delete lgtB in Tr5. The second was the recombination of a fragment of two genes, lgtB and lgtH4, to create an inactive lgtH9 allele with a mosaic structure in Tr7. These findings suggest that besides phase variation, homologous recombination can contribute to the genetic diversity of the lgt locus and to the generation of LOS variation in N. meningitidis. [Copyright &y& Elsevier]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - OLIGOSACCHARIDES
KW - LIPIDS
KW - Glycosyltransferase
KW - Immunotype
KW - lgt
KW - Lipooligosaccharide
KW - Neisseria
N1 - Accession Number: 7920729; Zhu, Peixuan; Email Address: zhu@cber.fda.gov Tsai, Chao-Ming 1 Frasch, Carl E. 1; Affiliation: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Nov2002, Vol. 34 Issue 3, p193; Subject Term: NEISSERIA meningitidis; Subject Term: OLIGOSACCHARIDES; Subject Term: LIPIDS; Author-Supplied Keyword: Glycosyltransferase; Author-Supplied Keyword: Immunotype; Author-Supplied Keyword: lgt; Author-Supplied Keyword: Lipooligosaccharide; Author-Supplied Keyword: Neisseria; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Little, A.R.
AU - Benkovic, S.A.
AU - Miller, D.B.
AU - O’Callaghan, J.P.
T1 - Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines11 Portions of this work have appeared in abstract form [Little, A.R., O’Callaghan, J.P., Soc. Neurosci. Abstr. 25 (1999) 1535; Little, A.R., O’Callaghan, J.P., Toxicologist 48 (1999) 239].
PB - Springer Science & Business Media B.V.
AB - The HIV epidemic disproportionately affects historically underserved members of racial/ethnic minorities. This paper compares HIV service use patterns for 653 Asians and Pacific Islanders (APIs) with those of other racial and ethnic minority clients (N = 28,201) at three selected Ryan White Comprehensive AIDS Resource Emergency (CARE) Act grantee sites in California. Study results show a relatively high proportion of APIs with advanced HIV disease. APIs use hospital-based HIV clinics at relatively high rates, and they use HIV case management, housing assistance, day/respite care, food/nutrition, substance abuse treatment, and health education services in relatively low numbers. Research suggests that social, cultural, and economic factors may influence health seeking behaviors and providers' practices. While there are relatively few APIs living with HIV in the US, the rate of API population growth from immigration underscores the need for service providers to take into account cultural and social factors to improve access to treatment.
SN - 0094-5145
AD - HIV/AIDS Bureau, Office of Science and Epidemiology, Health Resources and Services Administration, Rockville, MD 20857; mpounds@hrsa.gov
U2 - PMID: 12458783.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bell, Jennifer L.
T1 - Changes in logging injury rates associated with use of feller-bunchers in West Virginia
JO - Journal of Safety Research
JF - Journal of Safety Research
Y1 - 2002/12//
VL - 33
IS - 4
M3 - Article
SP - 463
SN - 00224375
AB - Problem: It is well documented that logging is one of the most dangerous occupations and industries in which to work, and trees fellers are at greatest risk of injury. The objective of this study was to determine whether West Virginia (WV) logging companies experienced a reduction in injuries after beginning to use feller-bunchers (tree cutting machines, which replace some of the work done with a chainsaw) during harvesting operations. Methods: WV workers compensation claims and employment data from 1995 to 2000 were used to calculate injury rates. Injury trends in the rest of the WV logging industry, not using feller-bunchers, were also assessed. Results: For 11 companies, the pre-feller-buncher injury claims rate was 19.4 per 100 workers and the post-feller-buncher rate was 5.2 per 100 workers. This was a significant difference, with an adjusted rate ratio of 2.8 (95% CI: 1.8–4.5) of pre to post claims. Struck by injuries also showed significant decline, with the pre-feller-buncher injury rate being 3.8 (95% CI: 1.8–8.2) times as great as post-feller-buncher rate. During the time of the study, the injury rate rose in the rest of the WV logging industry. The average cost of a workers compensation claim in the WV logging industry during the time of the study was approximately $10,400. Impact on industry: As mechanization of logging tasks becomes more widespread, the WV logging industry as a whole may see substantial injury declines and a reduction in the total cost of injury claims. Struck by injuries, the most common and potentially fatal of logging injury types, appear to be particularly affected. However, logging operations in areas of very steep terrain where it is not possible to use these machines may need to rely on strategies other than feller-bunchers to reduce injuries. [Copyright &y& Elsevier]
AB - Copyright of Journal of Safety Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Logging -- Accidents
KW - Work-related injuries
KW - West Virginia
KW - United States
KW - Feller-buncher
KW - Logging
KW - Mechanization
KW - Occupational injuries
KW - Workers' compensation
N1 - Accession Number: 7787033; Bell, Jennifer L. 1; Email Address: Jbell@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road, MS-1181, Morgantown, WV 26505-2888, USA; Issue Info: Dec2002, Vol. 33 Issue 4, p463; Subject Term: Logging -- Accidents; Subject Term: Work-related injuries; Subject: West Virginia; Subject: United States; Author-Supplied Keyword: Feller-buncher; Author-Supplied Keyword: Logging; Author-Supplied Keyword: Mechanization; Author-Supplied Keyword: Occupational injuries; Author-Supplied Keyword: Workers' compensation; NAICS/Industry Codes: 113312 Contract logging; NAICS/Industry Codes: 113311 Logging (except contract); NAICS/Industry Codes: 113310 Logging; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mark, Tami L.
AU - Dilonardo, Joan D.
AU - Chalk, Mady
AU - Coffey, Rosanna M.
T1 - Trends in inpatient detoxification services, 1992–1997
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
Y1 - 2002/12//
VL - 23
IS - 4
M3 - Article
SP - 253
SN - 07405472
AB - The paper examines trends in the use of inpatient substance abuse detoxification provided at general hospitals using data from the Healthcare Utilization and Cost Project – National Inpatient Survey. Most persons who received inpatient detoxification did not also receive rehabilitation while an inpatient. The percentage receiving rehabilitation declined between 1992 and 1997 from 38.9% to 21.1%. The decrease in the probability of receiving rehabilitation occurred across gender, age, region, insurance status, income levels, diagnoses, admission source, and discharge destination. Two other notable trends are that average length of stay for detoxification dropped by one third over the six-year period, from 7.7 days to 5.2 days and the percentage of admissions through the emergency room increased from 35.6% to 40.1%. Detoxification offers an opportunity to link patients with rehabilitation. This analysis indicates that those opportunities may be missed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Substance Abuse Treatment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DETOXIFICATION (Substance abuse treatment)
KW - SUBSTANCE abuse -- Treatment
KW - Detoxification
KW - Drug abuse
KW - Rehabilitation
KW - Substance abuse
KW - Trends
N1 - Accession Number: 8669135; Mark, Tami L. 1; Email Address: Tami.Mark@Medstat.Com Dilonardo, Joan D. 2 Chalk, Mady 2 Coffey, Rosanna M. 1; Affiliation: 1: The MEDSTAT Group, Inc., 4301 Connecticut Avenue NW, Suite 330, Washington, DC, 20008, USA 2: Office of Quality Improvement and Financing, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Administration, Rockwall II Building, Suite 740 5515 Security Lane, Rockville, MD 20852, USA; Source Info: Dec2002, Vol. 23 Issue 4, p253; Subject Term: DETOXIFICATION (Substance abuse treatment); Subject Term: SUBSTANCE abuse -- Treatment; Author-Supplied Keyword: Detoxification; Author-Supplied Keyword: Drug abuse; Author-Supplied Keyword: Rehabilitation; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Trends; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garnick, Deborah W.
AU - Lee, Margaret T.
AU - Chalk, Mady
AU - Gastfriend, David
AU - Horgan, Constance M.
AU - McCorry, Frank
AU - McLellan, A. Thomas
AU - Merrick, Elizabeth Levy
T1 - Establishing the feasibility of performance measures for alcohol and other drugs
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
Y1 - 2002/12//
VL - 23
IS - 4
M3 - Article
SP - 375
SN - 07405472
AB - The Washington Circle (a multiple-disciplinary group of providers, researchers, managed care representatives, and public policy representatives) examined three performance measures for alcohol and other drug (AOD) services. These measures, which were developed and applied to managed care organizations'' administrative data for their commercial enrollees, are: (a) identification, the percent of adult enrollees with AOD diagnoses; (b) initiation, the percent of adults with an inpatient AOD admission or with an index outpatient visit for AOD abuse or dependence and any additional AOD services within 14 days of identification; and (c) engagement, the percent of adults diagnosed with AOD disorders that receives two additional AOD services within 30 days of the initiation of care. We conclude that using administrative databases to compare managed care organizations'' performance is feasible, meaningful and informative. The article discusses issues in interpreting performance measures in several areas: organizational structure of alcohol and other drug services, information available for measurement, and computational issues. [Copyright &y& Elsevier]
AB - Copyright of Journal of Substance Abuse Treatment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANAGED care plans (Medical care)
KW - SUBSTANCE abuse -- Treatment
KW - Engagement
KW - Identification
KW - Initiation
KW - Measurement
KW - Performance
N1 - Accession Number: 8669148; Garnick, Deborah W. 1; Email Address: garnick@brandeis.edu Lee, Margaret T. 1 Chalk, Mady 2 Gastfriend, David 3 Horgan, Constance M. 1 McCorry, Frank 4 McLellan, A. Thomas 5 Merrick, Elizabeth Levy 1; Affiliation: 1: Schneider Institute for Health Policy, Heller School for Social Policy and Management, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA 2: Division of Services Improvment, Center for Substance Abuse Treatment, Rockville, MD 20857, USA 3: Addiction Research Program, Massachusetts General Hospital, Back Bay, Boston, MA 02115, USA 4: Clinical Services, New York Office of Alcoholism and Substance Abuse Services, New York, NY 10018-5903, USA 5: Treatment Research Institute, Philadelphia, PA 19106-3475, USA; Source Info: Dec2002, Vol. 23 Issue 4, p375; Subject Term: MANAGED care plans (Medical care); Subject Term: SUBSTANCE abuse -- Treatment; Author-Supplied Keyword: Engagement; Author-Supplied Keyword: Identification; Author-Supplied Keyword: Initiation; Author-Supplied Keyword: Measurement; Author-Supplied Keyword: Performance; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106796253
T1 - Device safety. When bed isn't a safe haven.
AU - Todd JF
Y1 - 2002/12//
N1 - Accession Number: 106796253. Language: English. Entry Date: 20030117. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Beds and Mattresses
KW - Patient Safety
KW - Aged
SP - 82
EP - 82
JO - Nursing
JF - Nursing
JA - NURSING
VL - 32
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 12512500.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106826084
T1 - Factors that influence receipt of recommended preventive pediatric health and dental care.
AU - Yu SM
AU - Bellamy HA
AU - Kogan MD
AU - Dunbar JL
AU - Schwalberg RH
AU - Schuster MA
Y1 - 2002/12//Dec2002 Part 1
N1 - Accession Number: 106826084. Language: English. Entry Date: 20030207. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Note: Available online at http://www.pediatrics.org. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Federal Maternal and Child Health Bureau contract 240-97 and in part by CDC grant U48/CCU915773. NLM UID: 0376422.
KW - Dental Care for Children
KW - Preventive Health Care -- In Infancy and Childhood
KW - Adolescence
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Convenience Sample
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Infant
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Secondary Analysis
KW - Surveys
KW - Telephone
KW - United States
KW - Human
SP - 8p
EP - 8p
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 110
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: This study examined the factors that affect children's receipt of recommended well-child and dental visits using nationally representative data. METHODS: We analyzed the Child Public Use File of the 1999 National Survey of America's Families, including 35 938 children who were younger than 18 years. Bivariate and multivariate analyses were conducted to examine the relationship between dependent variables, including receipt of well-child visits as recommended by the American Academy of Pediatrics' periodicity schedule and dental visits as recommended by the American Academy of Pediatric Dentistry and Bright Futures, and independent variables, including health status and sociodemographic and economic indicators. RESULTS: Overall, 23.4% of children did not receive the recommended well-child visits, whereas 46.8% did not receive the recommended number of dental visits. The factors that predict nonreceipt of care differed for well-child and dental care and with child's age. Logistic regression reveals that children who were young (<10 years old), uninsured, non-Hispanic white, had a parent who was less than college educated, or in poor health were least likely to meet the recommendations for well-child care. Children who did not meet the dental recommendation were more likely to be black, uninsured, from families with low incomes, have a parent who was less than college educated, and have postponed dental care in the last year. These risk factors increased with children's age. CONCLUSIONS: A substantial proportion of US children do not receive preventive care according to professionally recommended standards, particularly dental care. Publicly insured children experience higher rates of recommended well-child visits; however, much improvement is needed among public programs in providing recommended dental care, especially among adolescents and children in poor general health. [Abstract for this article also available on page 1242 of printed version. Full article available at www.pediatrics.org/cgi/content/full/110/6/e73]
SN - 0031-4005
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers La, 18-41, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 12456940.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dhawan, Subhash
T1 - Design and construction of novel molecular conjugates for signal amplification (I): conjugation of multiple horseradish peroxidase molecules to immunoglobulin via primary amines on lysine peptide chains
JO - Peptides
JF - Peptides
Y1 - 2002/12//
VL - 23
IS - 12
M3 - Article
SP - 2091
SN - 01969781
AB - Immunoconjugates are widely used for indirect detection of analytes (such as antibodies or antigens) in a variety of immunoassays. However, the availability of functional groups such as primary amines or free sulfhydryls in an immunoglobulin molecule is the limiting factor for optimal conjugation and, therefore, determines the sensitivity of an assay. In the present study, an N-terminal bromoacetylated 20 amino acid peptide containing 20 lysine residues was conjugated to N-succinimidyl-S-acetylthioacetate (SATA)-modified IgG or free sulfhydryl groups on 2-mercaptoethylamine (2-MEA)-reduced IgG molecules via a thioether (S&z.sbnd;CH2CONH) linkage to introduce multiple reactive primary amines per IgG. These primary amines were then covalently coupled with maleimide-activated horseradish peroxidase (HRP). The poly-HRP–antibody conjugates thus generated demonstrated greater than 15-fold signal amplification upon reaction with orthophenyldiamine substrate. The poly-HRP–antibody conjugates efficiently detected human immunodeficiency virus (HIV)-1 antibodies in plasma specimens with significantly higher sensitivity than conventionally prepared HRP–antibody conjugates in an HIV-1 solid-phase enzyme immunoassay and Western blot analysis. The signal amplification techniques reported here could have the potential for development of highly sensitive immunodiagnostic assay systems. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEPTIDES
KW - ANTIBODY-toxin conjugates
KW - Enzyme conjugates
KW - Lysine
KW - Peptide
KW - Signal amplification
N1 - Accession Number: 8903643; Dhawan, Subhash 1; Email Address: dhawan@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Virology, Immunopathogenesis Section, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315), Rockville, MD 20852-1448, USA; Source Info: Dec2002, Vol. 23 Issue 12, p2091; Subject Term: PEPTIDES; Subject Term: ANTIBODY-toxin conjugates; Author-Supplied Keyword: Enzyme conjugates; Author-Supplied Keyword: Lysine; Author-Supplied Keyword: Peptide; Author-Supplied Keyword: Signal amplification; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dhawan, Subhash
T1 - Design and construction of novel molecular conjugates for signal amplification (II): use of multivalent polystyrene microparticles and lysine peptide chains to generate immunoglobulin–horseradish peroxidase conjugates
JO - Peptides
JF - Peptides
Y1 - 2002/12//
VL - 23
IS - 12
M3 - Article
SP - 2099
SN - 01969781
AB - Spherical polystyrene microparticles expressing a large number of highly reactive functional groups were chemically engineered to generate antibody–enzyme conjugates as novel signal amplification systems. Chemically modified goat anti-human IgG and horseradish peroxidase (HRP) were combined in a 1:5 ratio and attached to 0.44 μm streptavidin microparticles or N-succinimidyl-S-acetylthioacetate (SATA)-activated 0.29 μm amino microparticles with highly reactive free sulfhydryl groups on their surface. The numbers of HRP molecules/microparticle were further increased by coupling HRP to primary amines on N-terminal biotinylated or bromoacetylated polypeptides containing 20 lysine residues prior to conjugation with streptavidin or sulfhydryl groups-containing microparticles. The antibody–poly-HRP immunoconjugates contained an estimated number of 105 HRP/streptavidin microparticle and 106 HRP/amino microparticle, respectively. These microparticle immunoconjugates efficiently bound to plasma anti-HIV-1 antibodies that had been captured by HIV antigens on 5 μm carboxyl magnetic microparticles and, upon reaction with orthophenyldiamine substrate, produced a detection signal with 5–8 times more sensitivity as compared to conventional HRP-conjugated goat anti-human IgG. The signal amplification technique by microparticle immunoconjugates may provide potentially novel tools for the development of highly sensitive diagnostic systems. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEPTIDES
KW - POLYSTYRENE
KW - Diagnostic assays
KW - Enzyme conjugates
KW - Microparticle
KW - Peptide
KW - Signal amplification
N1 - Accession Number: 8903644; Dhawan, Subhash 1; Email Address: dhawan@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Virology, Immunopathogenesis Section, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315), Rockville, MD 20852-1448, USA; Source Info: Dec2002, Vol. 23 Issue 12, p2099; Subject Term: PEPTIDES; Subject Term: POLYSTYRENE; Author-Supplied Keyword: Diagnostic assays; Author-Supplied Keyword: Enzyme conjugates; Author-Supplied Keyword: Microparticle; Author-Supplied Keyword: Peptide; Author-Supplied Keyword: Signal amplification; NAICS/Industry Codes: 326140 Polystyrene Foam Product Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106822362
T1 - Skin diseases of travelers.
AU - Joyce MP
Y1 - 2002/12//2002 Dec
N1 - Accession Number: 106822362. Language: English. Entry Date: 20030411. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0430463.
KW - Travel Health
KW - Skin Diseases
KW - Skin Diseases, Parasitic
KW - Skin Diseases -- Physiopathology
KW - Skin Diseases -- Diagnosis
SP - 971
EP - 981
JO - Primary Care
JF - Primary Care
JA - PRIM CARE
VL - 29
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Dermatologic problems are frequent in travelers. In addition to common ailments that may occur independently of travel, the physician must consider several other causes that are based on the patient's exposure and travel history. This article reviews different skin disorders with which many travelers present upon their return from abroad. Copyright © 2002 by W.B. Saunders Company
SN - 0095-4543
AD - Medical Services, National Hansen's Disease Programs, 1770 Physicians Park Dr, Baton Rouge, LA 70816; pjoyce@hrsa.gov
U2 - PMID: 12687902.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 119720827
T1 - Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women.
AU - Austin, Harland
AU - Chimowitz, Marc I
AU - Hill, Holly A
AU - Chaturvedi, Seemant
AU - Wechsler, Lawrence R
AU - Wityk, Robert J
AU - Walz, Elizabeth
AU - Wilterdink, Janet L
AU - Coull, Bruce
AU - Sila, Cathy A
AU - Mitsias, Panos
AU - Evatt, Bruce
AU - Hooper, W Craig
Y1 - 2002/12//2002 Dec
N1 - Accession Number: 119720827. Corporate Author: Genetics and Stroke in the Young Study Group. Language: English. Entry Date: 20030815. Revision Date: 20161126. Publication Type: journal article. Commentary: Hegele Robert A. Genetic association studies of stroke: hope, signal, and noise. (STROKE) 2002 Dec; 33 (12): 2769-2769; Hankey Graeme J, Eikelboom John W. Editorial comment--Routine thrombophilia testing in stroke patients is unjustified. (STROKE) 2003 Aug; 34 (8): 1826-1827. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266.
KW - Polymorphism, Genetic
KW - Blood Coagulation Factors
KW - Genetics
KW - Stroke -- Diagnosis
KW - Stroke
KW - Case Control Studies
KW - Adult
KW - United States
KW - Stroke -- Epidemiology
KW - Blacks
KW - Human
KW - Tissue Plasminogen Activator
KW - Female
KW - Middle Age
KW - Prevalence
KW - Risk Factors
KW - Odds Ratio
KW - Sequence Analysis
KW - Genes
KW - Risk Assessment
KW - Stroke -- Blood
KW - Male
KW - Causal Attribution
KW - Stroke -- Classification
KW - Whites
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
SP - 2762
EP - 2768
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 33
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background and Purpose: The purpose of the present study was to compare the prevalences of genetic polymorphisms in persons with cryptogenic stroke with those among stroke patients with evidence of large-artery occlusive disease or an unequivocal cardioembolic source (noncryptogenic stroke).Methods: We compared the prevalences of genetic polymorphisms thought to be related to thrombi formation in young stroke patients with evidence of large-artery occlusive disease or an unequivocal cardioembolic source (noncryptogenic stroke; controls; n=79) with those in young stroke patients without such sources (cryptogenic stroke; cases; n=67). Common variations in the genes encoding factor V, prothrombin, angiotensin I-converting enzyme, 5,10-methylenetetrahydrofolate reductase, endothelial cell nitric oxide synthase, tissue plasminogen activator, plasminogen activator inhibitor-1, and fibrinogen were evaluated. We also compared the allele prevalence of these genes among all stroke patients with those among a large pool of historical controls assayed for these genes.Results: None of these genetic polymorphisms was statistically significantly related to cryptogenic stroke. With respect to a comparison of all ischemic stroke with historical controls, only the prevalence of tissue plasminogen activator D allele among stroke subjects was statistically significantly higher than that of the historical controls (P=0.0014).Conclusions: These findings generally do not support the hypothesis that genes associated with a prothrombotic state are risk factors among a subgroup of young people with stroke of undetermined cause. Except for the D tissue plasminogen activator allele, the findings also indicated that these genetic factors are unrelated, or only weakly related, to all ischemic stroke.
SN - 0039-2499
AD - Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Ga, USA
U2 - PMID: 12468767.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stirling, Dale
AU - Junod, Suzanne
T1 - Arnold J. Lehman.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2002/12//
VL - 70
IS - 2
M3 - Article
SP - 159
EP - 160
PB - Oxford University Press / USA
SN - 10966080
AB - The article profiles Arnold J. Lehman, a pioneer of toxicology in the U.S. He was born in Good Thunder, Minnesota and obtained his Bachelor of Science (B.S.) and Master of Science (M.S.) degrees from the University of Washington. Lehman became a Professor of Pharmacology at George Washington University Medical School and was appointed to head the Pharmacology Division of the U.S. Food and Drug Administration (FDA). He is the principal author of the publication "Procedures for the Appraisal of the Toxicity of Chemicals in Food."
KW - Toxicologists
KW - Educational background
KW - Career development
KW - United States
KW - United States. Food & Drug Administration
KW - Lehman, Arnold J.
N1 - Accession Number: 44406435; Stirling, Dale 1; Email Address: dastirling@intertox.com; Junod, Suzanne 2; Affiliations: 1: Intertox, Inc., 2819 Elliott Avenue, Suite 201, Seattle, Washington 98121; 2: Food And Drug Administration, History Office, HFC-24, 5600 Fishers Lane Rockville, Maryland 20857; Issue Info: Dec2002, Vol. 70 Issue 2, p159; Thesaurus Term: Toxicologists; Subject Term: Educational background; Subject Term: Career development; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; NAICS/Industry Codes: 611430 Professional and Management Development Training; People: Lehman, Arnold J.; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Johnson, Elizabeth Anne
T1 - Pesticides, metals, microbials and venoms: the stuff of neurotoxicology
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
Y1 - 2002/12//
VL - 23
IS - 12
M3 - Article
SP - 584
SN - 01656147
N1 - Accession Number: 8548400; Johnson, Elizabeth Anne 1; Email Address: edj2@cdc.gov; Affiliation: 1: Chronic Stress and Neurotoxicology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division/National Institute for Occupational Safety and Health, Centers for Disease Control, Morgantown, WV 26505, USA; Source Info: Dec2002, Vol. 23 Issue 12, p584; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Santos, Norma
AU - Volotão, Eduardo M.
AU - Soares, Caroline C.
AU - Albuquerque, Maria Carolina M.
AU - da Silva, Fabiano M.
AU - Chizhikov, Vladimir
AU - Hoshino, Yasutaka
T1 - VP7 gene polymorphism of serotype G9 rotavirus strains and its impact on G genotype determination by PCR
JO - Virus Research
JF - Virus Research
Y1 - 2002/12//
VL - 90
IS - 1/2
M3 - Article
SP - 1
SN - 01681702
AB - Rotaviruses are the single most important etiologic agents of severe diarrhea of infants and young children worldwide. Surveillance of rotavirus serotypes/genotypes (both VP7[G] and VP4[P]) is in progress globally in which polymerase chain reaction (PCR) has been the assay of choice. We investigated polymorphism of the VP7 gene of serotype G9 rotavirus strains and its impact on the determination of VP7 gene genotype by PCR assay. By VP7 gene sequence analysis, we and others have previously shown that the G9 rotavirus strains belong to one of three VP7 gene lineages. By PCR assay using three different sets of commonly used primers specific for G1-4, 8 and 9, 23 Brazilian G9 strains and 5 well-characterized prototype G9 strains which collectively represented all three VP7 gene lineages were typed as: (i) G3; (ii) G4; (iii) G9; (iv) G3 and G9; or (v) G9 and G4 depending on a primer pool employed. This phenomenon appeared to be due to: (i) a VP7 gene lineage-specific polymorphism, more specifically mutation(s) in the primer binding region of the VP7 gene of G9 strain; and (ii) the magnitude of difference in nucleotide homology at respective primer binding site between homotypic (G9) and heterotypic (G3 or G4) primers present in a primer pool employed. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - POLYMERASE chain reaction
KW - GASTROENTERITIS
KW - Gastroenteritis
KW - PCR G genotyping
KW - Rotavirus
KW - VP7 gene polymorphism
N1 - Accession Number: 8571867; Santos, Norma 1; Email Address: nsantos@micro.ufrj.br Volotão, Eduardo M. 1 Soares, Caroline C. 1 Albuquerque, Maria Carolina M. 1 da Silva, Fabiano M. 1 Chizhikov, Vladimir 2 Hoshino, Yasutaka 3; Affiliation: 1: Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS-Bl. I, Ilha do Fundão, Rio de Janeiro, RJ 21.941-590, Brazil 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD 20895, USA 3: Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Dec2002, Vol. 90 Issue 1/2, p1; Subject Term: ROTAVIRUSES; Subject Term: POLYMERASE chain reaction; Subject Term: GASTROENTERITIS; Author-Supplied Keyword: Gastroenteritis; Author-Supplied Keyword: PCR G genotyping; Author-Supplied Keyword: Rotavirus; Author-Supplied Keyword: VP7 gene polymorphism; Number of Pages: 14p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8571867&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-17074-001
AN - 2004-17074-001
AU - Clark, H. Westley
AU - Horton, Arthur MacNeill Jr.
AU - Dennis, Michael
AU - Babor, Thomas F.
T1 - Moving from research to practice just in time: The treatment of cannabis use disorders comes of age.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2002/12//
VL - 97
IS - Suppl1
SP - 1
EP - 3
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Horton, Arthur MacNeill Jr., Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-17074-001. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Clark, H. Westley; Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cannabis; Client Characteristics; Drug Abuse; Drug Rehabilitation; Marijuana Usage. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 3. Issue Publication Date: Dec, 2002.
AB - This supplement issue on the treatment of marijuana use disorders describes two large multi-site field experiments: the Cannabis Youth Treatment (CYT) study with adolescents and the Marijuana Treatment Project (MTP) with adults. The papers cover multiple aspects of the treatment of cannabis users, including the rationale for studying cannabis use disorders, descriptions of the CYT and MTP studies, characteristics of adolescents and adults presenting for treatment of cannabis use disorders, court diversion issues, economic evaluation and confirmation of self-reported cannabis use, among other topics. This Introduction provides background information and an overview of the papers from the perspective of the funding agency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cannabis use disorders
KW - Cannabis Youth Treatment study
KW - Marijuana Treatment Project
KW - client characteristics
KW - 2002
KW - Cannabis
KW - Client Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Marijuana Usage
KW - 2002
DO - 10.1046/j.1360-0443.97.s01.11.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17074-001&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-01073-001
AN - 2002-01073-001
AU - Davis, Nancy J.
T1 - The promotion of mental health and the prevention of mental and behavioral disorders: Surely the time is right.
JF - International Journal of Emergency Mental Health
JO - International Journal of Emergency Mental Health
JA - Int J Emerg Ment Health
Y1 - 2002///Win 2002
VL - 4
IS - 1
SP - 3
EP - 30
CY - US
PB - Chevron Publishing
SN - 1522-4821
AD - Davis, Nancy J., CMHS/SAMHSA, 5600 Fishers Lane, Room 17C-05, Rockville, MD, US, 20857
N1 - Accession Number: 2002-01073-001. Other Journal Title: International Journal of Emergency Mental Health and Human Resilience. Partial author list: First Author & Affiliation: Davis, Nancy J.; US Dept of Health & Human Services, Ctr for Mental Health Services Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Other Publishers: OMICS Group. Release Date: 20020731. Correction Date: 20140728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Promotion; Mental Health; Mental Health Services; Primary Mental Health Prevention. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 28. Issue Publication Date: Win 2002.
AB - Provides an overview of key issues related to promotion and prevention. It examines the increasing role mental disorders play in the global burden of disease, controversies surrounding constructs such as mental health and prevention, and the links among promotion, prevention, treatment and recovery. After discussing disorders often targeted for prevention, it enumerates principles for effective programs and examples of findings from evidence-based programs. It presents recommendations for the prevention science field and concludes with information about the worldwide response to the need for promotion and prevention services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - promotion
KW - mental disorders
KW - behavioral disorders
KW - prevention
KW - 2002
KW - Health Promotion
KW - Mental Health
KW - Mental Health Services
KW - Primary Mental Health Prevention
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-01073-001&site=ehost-live&scope=site
UR - ndavis1@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17074-002
AN - 2004-17074-002
AU - Dennis, Michael
AU - Babor, Thomas F.
AU - Roebuck, M. Christopher
AU - Donaldson, Jean
T1 - Changing the focus: The case for recognizing and treating cannabis use disorders.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2002/12//
VL - 97
IS - Suppl1
SP - 4
EP - 15
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Dennis, Michael, Chestnut Health Systems, 720 West Chestnut, Bloomington, IL, US, 61701
N1 - Accession Number: 2004-17074-002. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Dennis, Michael; Chestnut Health Systems (CHS), Bloomington, IL, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cannabis; Drug Abuse; Drug Rehabilitation; Epidemiology. Minor Descriptor: Models; Treatment; Trends. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 12. Issue Publication Date: Dec, 2002.
AB - During the late 1960s, cannabis emerged from relative obscurity to become the most common illicit drug used in the United States, and has remained so ever since. From an epidemiological perspective, three major waves of successively younger new users can be identified during the past 40 years. Contrary to popular opinion, cannabis use can be problematic for many people (particularly adolescents). Moreover, the drug has become increasingly more potent. Cannabis is currently one of the leading substances reported in arrests, emergency room admissions, autopsies and treatment admissions. like alcohol and tobacco, the need for effective approaches to treating cannabis use disorders transcends debates about whether it should be legal. Moreover, the costs to society are continuing to mount from past neglect of this continuing public health problem. This paper provides background on the need to develop effective models for treating cannabis use disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cannabis use disorder
KW - epidemiology
KW - treatment
KW - illicit drug use
KW - treatment models
KW - trends
KW - 2002
KW - Cannabis
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Epidemiology
KW - Models
KW - Treatment
KW - Trends
KW - 2002
DO - 10.1046/j.1360-0443.97.s01.10.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17074-002&site=ehost-live&scope=site
UR - mdennis@chestnut.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17074-003
AN - 2004-17074-003
AU - Dennis, Michael
AU - Titus, Janet C.
AU - Diamond, Guy
AU - Donaldson, Jean
AU - Godley, Susan H.
AU - Tims, Frank M.
AU - Webb, Charles
AU - Kaminer, Yifrah
AU - Babor, Thomas
AU - Roebuck, M. C.
AU - Godley, Mark D.
AU - Hamilton, Nancy
AU - Liddle, Howard
AU - Scott, Christy K.
T1 - The Cannabis Youth Treatment (CYT) experiment: Rationale, study design and analysis plans.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2002/12//
VL - 97
IS - Suppl1
SP - 16
EP - 34
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Dennis, Michael, Chestnut Health Systems, 720 West Chestnut, Bloomington, IL, US, 61701
N1 - Accession Number: 2004-17074-003. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Dennis, Michael; Chestnut Health Systems (CHS), Bloomington, IL, US. Institutional Authors: C. Y. T. Steering Committee. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040913. Correction Date: 20131014. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Health Care Costs; Treatment Effectiveness Evaluation. Minor Descriptor: Cannabis; Cognitive Behavior Therapy; Family Therapy; Models; Social Support; Treatment. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Parenting Practice Scale; Adolescent Reasons for Quitting Questionnaire; f) Dimensions of Temperament Survey-Revised; Child Behavior Checklist; Adolescent Relapse Coping Questionnaire DOI: 10.1037/t04749-000; Family Environment Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Dec, 2002.
AB - Aims: This paper provides a description of the rationale, study design, treatments and assessment procedures used in the Cannabis Youth Treatment (CYT) experiment. Design: CYT was designed to (a) test the relative effectiveness, cost and benefit-cost of five promising treatment interventions under field conditions and (b) provide evidence based manual-guided models of these interventions to the treatment field. Setting: The study involved two community-based treatment programs and two major medical centers. Participants: Participants were 600 adolescents recruited from the regular intake who were between the ages of 12 and 18, had used marijuana in the past 90 days, and met one or more criteria of dependence or abuse. Interventions: Participants were randomly assigned to one of five interventions: Motivational Enhancement Therapy (MET), Cognitive Behavioral Therapy (CUT), Family Support Network (FSN), Adolescent Community Reinforcement Approach (ACRA), or Multidimensional Family Therapy (MDFT). Measurements: Self-report data were collected at intake, 3,6,9 and 12 months post discharge using the Global Appraisal of Individual Needs (GAIN), as well as several supplemental self-reports, collateral reports, urine testing, and service logs. Findings: This paper reports on the study's implementation including the psychometric properties of the measures (alphas over 0.8), validity of self-report (kappa over 0.6), high rates of treatment completion (81% completed two or more months), and high rates of follow-up (over 94% per wave). Conclusions The feasibility of implementing the CYT manual-guided treatment and quality assurance model in community-based adolescent treatment programs is discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cannabis youth treatment
KW - treatment effectiveness
KW - treatment costs
KW - motivational enhancement therapy
KW - cognitive behavioral therapy
KW - family support network
KW - multidimensional family therapy
KW - models
KW - 2002
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Costs
KW - Treatment Effectiveness Evaluation
KW - Cannabis
KW - Cognitive Behavior Therapy
KW - Family Therapy
KW - Models
KW - Social Support
KW - Treatment
KW - 2002
DO - 10.1046/j.1360-0443.97.s01.2.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17074-003&site=ehost-live&scope=site
UR - mdennis@chestnut.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17074-008
AN - 2004-17074-008
AU - French, Michael T.
AU - Roebuck, M. Christopher
AU - Dennis, Michael L.
AU - Diamond, Guy
AU - Godley, Susan H.
AU - Tims, Frank
AU - Webb, Charles
AU - Herrell, James M.
T1 - The economic cost of outpatient marijuana treatment for adolescents: Findings from a multi-site field experiment.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2002/12//
VL - 97
IS - Suppl1
SP - 84
EP - 97
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - French, Michael T., Medical University of South Carolina, Department of Health Administration and Policy, 19 Hagwood Avenue, Suite 408, PO Box 25 0807, Charleston, SC, US, 29425
N1 - Accession Number: 2004-17074-008. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: French, Michael T.; Department of Health Administration and Policy, Medical University of South Carolina, Charleston, SC, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Drug Rehabilitation; Health Care Costs; Marijuana; Outpatient Treatment. Minor Descriptor: Adolescent Psychology. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Tests & Measures: Drug Abuse Treatment Cost Analysis Program Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Dec, 2002.
AB - Aims: Despite recent advances in the economic evaluation of adult substance abuse treatment, information and basic research is lacking on the cost of adolescent substance abuse treatment. The present study conducted an economic cost analysis of several outpatient adolescent treatment approaches. Design: The Cannabis Youth Treatment (CYT) study evaluated five structured treatments for cannabis-using adolescents. One of the approaches was implemented by all of the four geographically and institutionally diverse treatment facilities collaborating in CYT; each of the other four approaches was implemented in two of the sites. Using the Drug Abuse Treatment Cost Analysis Program (DATCAP), the economic cost of each site-specific treatment was determined. Findings: The average economic costs of the five types of outpatient treatments ranged from $837 to $3334 per episode, and varied by both direct factors (e.g. hours of treatment, treatment retention) and indirect factors (e.g. cost of living, staff level, case-load variation). Conclusions: These adolescent treatment cost estimates are examined in terms of their calculation, variability by condition, variability by site within condition and comparability with previous DATCAP results from outpatient drug-free programs for adults. Future research will integrate treatment outcomes and costs to complete cost-effectiveness and benefit-cost analyses of the five therapies (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - economic cost
KW - outpatient marijuana treatment for adolescents
KW - cost analysis
KW - 2002
KW - Costs and Cost Analysis
KW - Drug Rehabilitation
KW - Health Care Costs
KW - Marijuana
KW - Outpatient Treatment
KW - Adolescent Psychology
KW - 2002
DO - 10.1046/j.1360-0443.97.s01.4.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17074-008&site=ehost-live&scope=site
UR - frenchm@musc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17074-011
AN - 2004-17074-011
AU - Vendetti, Janice
AU - McRee, Bonnie
AU - Miller, Michael
AU - Christiansen, Kenneth
AU - Herrell, James
T1 - Correlates of pre-treatment drop-out among persons with marijuana dependence.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2002/12//
VL - 97
IS - Suppl1
SP - 125
EP - 134
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Vendetti, Janice, University of Connecticut Health Center, Department of Community Medicine and Health Care, 263 Farmington Avenue, Farmington, CT, US, 06030-6325
N1 - Accession Number: 2004-17074-011. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Vendetti, Janice; University of Connecticut Health Center, Department of Community Medicine and Health Care, Farmington, CT, US. Institutional Authors: Marjuana Treatment Project Research Group. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040913. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Drug Dependency; Drug Rehabilitation; Marijuana Usage; Treatment Dropouts. Minor Descriptor: Demographic Characteristics; Educational Attainment Level; Employment Status; Professional Referral. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Structured Clinical Interview for DSM-IV (SCID). Methodology: Clinical Trial; Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2002.
AB - Aims: Our objective was to identify client characteristics and other factors associated with pre-treatment drop-out by people with marijuana dependence. Design and participants: Data from the Marijuana Treatment Project's screening assessment were used to examine correlates of pre-treatment drop-out. Information from all eligible study participants (n=813) (i.e. those who were interested in receiving treatment for their marijuana dependence and were determined to be eligible for the randomized treatment efficacy trial) was used to examine differences between the 450 participants who initiated treatment (by enrolling in the trial) and the 363 individuals who declined enrollment. Setting: The study was conducted at three community-based outpatient treatment facilities in Farmington, CT, Seattle, WA and Miami, FL. Measurements: The information gathered in the screening interview included demographic characteristics, residential stability variables, employment and education history and referral source. Substance use variables included the number of days and the number of times per day marijuana was used, self-perceived dependence on marijuana, alcohol or other drugs, other drug use history and current treatment (i.e. substance abuse, medical, psychiatric) situation. Findings: Stepwise logistic regression was conducted to confirm variables associated with treatment initiation in bivariate analyses. Pre-treatment drop-out was associated with being younger, unmarried, unemployed, less educated and Asian American or Native American. It was also associated with self-perceived dependence on marijuana and use of other drugs. Conclusions: By recognizing demographic and substance use factors that may serve as barriers for individuals accessing treatment for marijuana dependence, clinicians may target clients with these characteristics proactively to encourage treatment initiation and subsequent attendance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marijuana dependence
KW - pre-treatment drop-out
KW - client characteristics
KW - demographic characteristics
KW - employment status
KW - education history
KW - referral
KW - 2002
KW - Client Characteristics
KW - Drug Dependency
KW - Drug Rehabilitation
KW - Marijuana Usage
KW - Treatment Dropouts
KW - Demographic Characteristics
KW - Educational Attainment Level
KW - Employment Status
KW - Professional Referral
KW - 2002
DO - 10.1046/j.1360-0443.97.s01.8.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17074-011&site=ehost-live&scope=site
UR - vendetti@ap.uchc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05236-006
AN - 2003-05236-006
AU - Powers, Regina H.
AU - Kniesner, Thomas J.
AU - Croghan, Thomas W.
T1 - Psychotherapy and pharmacotherapy in depression.
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2002/12//
VL - 5
IS - 4
SP - 153
EP - 161
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Powers, Regina H., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2003-05236-006. PMID: 14578549 Partial author list: First Author & Affiliation: Powers, Regina H.; U.S. Dept of Health and Human Services, Substance Abuse and Mental Health Services Administration, Office of Applied Statistics, Rockville, MD, US. Release Date: 20030616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Major Depression; Primary Health Care; Psychotherapy; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Methodology: Empirical Study; Longitudinal Study; Retrospective Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2002.
AB - Background: Depression is a condition with various modes of treatment, including pharmacotherapy, psychotherapy, and some combination of each. The role of psychotherapy in the treatment of depression relative to the role of pharmacotherapy is not well understood, and guidelines for psychotherapy in the primary care setting differ from guidelines for specialty care. There is little evidence concerning circumstances in actual practice that affect the use of psychotherapy in conjunction with pharmacotherapy. Aims of the Study: We retrospectively identify the most important factors associated with the use of psychotherapy in combination with pharmacotherapy in the treatment of depression. Specifically, we study provider choice, health plan characteristics, and patient characteristics. Methods: We use a comprehensive medical and pharmacy claims data sample of 1,023 individuals during 1992-1994. We select persons prescribed with an antidepressant medication and diagnosed with a depressive disorder by a primary care physician, psychiatrist, or non-physician mental health specialist. Controlling for depression diagnosis, comorbidity, and demographics, we examine the role of provider type and insurance plan benefit characteristics... (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression treatments
KW - pharmacotherapy
KW - psychotherapy
KW - combined treatment factors
KW - provider choice
KW - health plan benefit
KW - patient characteristics
KW - antidepressant medication
KW - 2002
KW - Drug Therapy
KW - Major Depression
KW - Primary Health Care
KW - Psychotherapy
KW - Treatment
KW - 2002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05236-006&site=ehost-live&scope=site
UR - RPowers@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-04838-002
AN - 2002-04838-002
AU - Pounds, Moses B.
AU - Conviser, Richard
AU - Ashman, Jill J.
AU - Bourassa, Virginia
T1 - Ryan White Care Act service use by Asian/Pacific Islanders and other clients in three California metropolitan areas (1997-1998).
JF - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JO - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JA - J Community Health
Y1 - 2002/12//
VL - 27
IS - 6
SP - 403
EP - 417
CY - Germany
PB - Springer
SN - 0094-5145
SN - 1573-3610
AD - Pounds, Moses B., HRSA/HAB/OSE, 5600 Fishers Lane, Room 7C07, Rockville, MD, US, 20857
N1 - Accession Number: 2002-04838-002. PMID: 12458783 Partial author list: First Author & Affiliation: Pounds, Moses B.; HIV/AIDS Bureau (HAB), Office of Science and Epidemiology (OSE), Health Resources and Services Administration (HRSA), Rockville, MD, US. Release Date: 20040809. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: American Public Health Association's Annual Meeting, Nov, 2000, Boston, MA, US. Conference Note: An earlier version of this paper was presented at the aforementioned conference. Major Descriptor: Asians; Health Care Services; Health Care Utilization; HIV; Pacific Islanders. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 2002.
AB - The HIV epidemic disproportionately affects historically underserved members of racial/ethnic minorities. This paper compares HIV service use patterns for 653 Asians and Pacific Islanders (APIs) with those of other racial and ethnic minority clients (N=28,201) at three selected Ryan White Comprehensive AIDS Resource Emergency (CARE) Act grantee sites in California. Study results show a relatively high proportion of APIs with advanced HIV disease. APIs use hospital-based HIV clinics at relatively high rates, and they use HIV case management, housing assistance, day/respite care, food/nutrition, substance abuse treatment, and health education services in relatively low numbers. Research suggests that social, cultural, and economic factors may influence health seeking behaviors and providers' practices. While there are relatively few APIs living with HIV in the US, the rate of API population growth from immigration underscores the need for service providers to take into account cultural and social factors to improve access to treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Ryan White Care Act service use
KW - Asians
KW - Pacific Islanders
KW - HIV service use
KW - health seeking behaviors
KW - 2002
KW - Asians
KW - Health Care Services
KW - Health Care Utilization
KW - HIV
KW - Pacific Islanders
KW - 2002
DO - 10.1023/A:1020649101613
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-04838-002&site=ehost-live&scope=site
UR - mpounds@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-11154-008
AN - 2002-11154-008
AU - Horton, Arthur MacNeill Jr.
AU - Roberts, Charles
T1 - Trail Making Test and malingering among substance abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2002/12//
VL - 112
IS - 12
SP - 1489
EP - 1496
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur MacNeill Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2002-11154-008. PMID: 12652900 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill Jr.; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20030129. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Assessment; Cutting Scores; Drug Abuse; Malingering. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2002.
AB - The Trail Making Test (TMT) is often used for screening cognitive impairments in substance abusers. A possible limitation of the TMT in clinical settings is that substance abusers may malinger and give poor effort. In this study, previously validated cutting scores for malingering were applied to a sample of 7,689 substance abusers (aged 18-44+ yrs) in drug abuse treatment programs. A mixed race sample was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study. Data were analyzed to determine the number of substance abusers that fell beyond the preset malingering cutting scores on the TMT. Results indicate that the TMT variables of seconds to complete Part A and Part B, and the ratio score of Part B divided by Part A (B/A), ranged from no subjects beyond the preset cutting score for Part B to 2.28% for Part A to 9.74% for the ratio score. Most substance abusers fell within preset cutting score ranges, a finding that suggests that their scores are valid. Another interpretation of the data, however, is that the cutoff scores were not particularly sensitive to biased responding. Further research is indicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Trail Making Test
KW - cognitive assessment
KW - substance abuse
KW - malingering
KW - cutting scores
KW - 2002
KW - Cognitive Assessment
KW - Cutting Scores
KW - Drug Abuse
KW - Malingering
KW - 2002
DO - 10.1080/00207450290158322
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-11154-008&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2002-11368-009
AN - 2002-11368-009
AU - Iyasu, Solomon
AU - Randall, Lelie L.
AU - Welty, Thomas K.
AU - Hsia, Jason
AU - Kinney, Hannah C.
AU - Mandell, Frederick
AU - McClain, Mary
AU - Randall, Brad
AU - Habbe, Don
AU - Wilson, Harry
AU - Willinger, Marian
T1 - Risk factors for sudden infant death syndrome among Northern Plains Indians.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2002/12//
VL - 288
IS - 21
SP - 2717
EP - 2723
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
AD - Iyasu, Solomon, Food & Drug Adminstration, Ctr for Drug Evaluation & Research, Office of Counter Terrorism & Pediatric Drug Development, Div of Pediatrics, 5600 Fishers Ln, Rockville, MD, US, 20857
N1 - Accession Number: 2002-11368-009. PMID: 12460095 Partial author list: First Author & Affiliation: Iyasu, Solomon; Food & Drug Administration, Ctr for Drug Evaluation & Research, Office of Counter Terrorsim & Pediatric Drug Development, Div of Pediatrics, Rockville, MD, US. Release Date: 20030428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; At Risk Populations; Risk Factors; Sudden Infant Death. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2002.
AB - Explored risk factors for sudden infant death syndrome (SIDS) among American Indians. A population-based case-control study of 33 SIDS infants and 66 matched living controls was carried out. Data sources included standardized parental interview, medical record abstraction, autopsy protocol, and infant death review. The proportions of case and control infants who were usually placed prone to sleep (15.2% and 13.6%, respectively), who shared a bed with parents (59.4% and 55.4 %), or whose mothers smoked during pregnancy (69.7% and 54.6 %) were similar. However, mothers of 72.7% of case infants and 45.5% of control infants engaged in binge drinking during pregnancy. Conditional logistic regression revealed significant associations between SIDS and 2 or more layers of clothing on the infant, any visits by a public health nurse, periconceptional maternal alcohol use, and maternal first-trimester binge drinking. Public health nurse visits, maternal alcohol use during the periconceptional period and first trimester, and layers of clothing appear to be risk factors for SIDS among Northern Plains Indians. Strengthening public health nurse visiting programs and programs to reduce alcohol consumption among women of childbearing age could potentially reduce the high rate of SIDS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sudden infant death syndrome
KW - risk factors
KW - American Indians
KW - 2002
KW - American Indians
KW - At Risk Populations
KW - Risk Factors
KW - Sudden Infant Death
KW - 2002
DO - 10.1001/jama.288.21.2717
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2002-11368-009&site=ehost-live&scope=site
UR - Iyasu@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106867035
T1 - Moving from research to practice just in time: the treatment of cannabis use disorders comes of age.
AU - Clark HW
AU - Horton AM Jr.
AU - Dennis M
AU - Babor TF
Y1 - 2002/12/02/Dec2002 Supplement 1
N1 - Accession Number: 106867035. Language: English. Entry Date: 20030912. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Dec2002 Supplement 1. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9304118.
KW - Cannabis
KW - Substance Use Disorders -- Therapy
KW - Street Drugs
KW - Serial Publications
SP - 1
EP - 3
JO - Addiction
JF - Addiction
JA - ADDICTION
VL - 97
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - This supplement issue on the treatment of marijuana use disorders describes two large multi-site field experiments: the Cannabis Youth Treatment (CYT) study with adolescents and the Marijuana Treatment Project (MTP) with adults. The papers cover multiple aspects of the treatment of cannabis users, including the rationale for studying cannabis use disorders, descriptions of the CYT and MTP studies,characteristics of adolescents and adults presenting for treatment of cannabis use disorders, court diversion issues, economic evaluation and confirmation of self-reported cannabis use, among other topics. This Introduction provides background information and an overview of the papers from the perspective of the funding agency.
SN - 0965-2140
AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD
U2 - PMID: 12460124.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106867035&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106860773
T1 - Occupational injury prevention research: progress and priorities.
AU - Stout NA
AU - Linn HI
Y1 - 2002/12/02/Dec2002 Supplement 4
N1 - Accession Number: 106860773. Language: English. Entry Date: 20030822. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Dec2002 Supplement 4. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Occupational-Related Injuries -- Prevention and Control
KW - Research Methodology
KW - Occupational Safety -- Legislation and Jurisprudence
SP - iv9
EP - 14
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 8
IS - 4
PB - BMJ Publishing Group
AB - The twentieth century witnessed remarkable reductions in the number and rate of occupational fatalities and injuries. However, many preventable injuries and deaths still occur. Barriers to progress in occupational injury prevention are discussed, along with strategies for overcoming them. In mining, the frequency of death has dramatically declined over the century. The latest figures from the BLS indicate that less than 6000 worker deaths from injury occurred in 2000. Catastrophic events have prompted increased attention, resources, and action on workplace hazards and risks, resulting in sweeping changes, including new protective laws. Science based approaches to prevention have contributed to progress. Multidisciplinary collaboration among injury prevention researchers, and collaboration and cooperation among multiple sectors, have improved the relevance and application of injury prevention research and development. Barriers to further progress include lack of evaluation of the effectiveness of prevention strategies and technologies, including cost effectiveness; lack of widespread implementation of known, effective prevention; and lack of efficient transfer and implementation of prevention knowledge and products to the workplace. Evaluation and implementation of prevention efforts are most successfully achieved in partnership between researchers and the industry at risk, which requires outreach efforts on the part of the occupational research community.
SN - 1353-8047
AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Viginia 26505; nas5@cdc.gov
U2 - PMID: 12460949.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106860773&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Califf, Robert M.
AU - Peterson, Eric D.
AU - Gibbons, Raymond J.
AU - Garson Jr, Arthur
AU - Brindis, Ralph G.
AU - Beller, George A.
AU - Smith Jr, Sidney C.
T1 - Integrating quality into thecycle of therapeutic development
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2002/12/04/
VL - 40
IS - 11
M3 - Article
SP - 1895
SN - 07351097
AB - The quality of healthcare, particularly as reflected in current practice versus the available evidence, has become a major focus of national health policy discussions. Key components needed to provide quality care include: 1) development of quality indicators and performance measures from specific practice guidelines, 2) better ways to disseminate such guidelines and measures, and 3) development of support tools to promote standardized practice. Although rational decision-making and development of practice guidelines have relied upon results of randomized trials and outcomes studies, not all questions can be answered by randomized trials, and many treatment decisions necessarily reflect physiology, intuition, and experience when treating individuals. Debate about the role of “evidence-based medicine” also has raised questions about the value of applying trial results in practice, and some skepticism has arisen about whether advocated measures of clinical effectiveness, the basic definition of quality, truly reflect a worthwhile approach to improving medical practice. We provide a perspective on this issue by describing a model that integrates quantitative measurements of quality and performance into the development cycle of existing and future therapeutics. Such a model would serve as a basic approach to cardiovascular medicine that is necessary, but not sufficient, to those wishing to provide the best care for their patients. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - MEDICAL policy
KW - ACC
KW - AHA
KW - American College of Cardiology
KW - American Heart Association
KW - clinical practice guideline
KW - CPG
KW - ESC
KW - European Society of Cardiology
KW - MI
KW - myocardial infarction
N1 - Accession Number: 8622662; Califf, Robert M. 1; Email Address: calif001@mc.duke.edu Peterson, Eric D. 1 Gibbons, Raymond J. 2 Garson Jr, Arthur 3 Brindis, Ralph G. 4 Beller, George A. 5 Smith Jr, Sidney C. 6; Affiliation: 1: Duke Clinical Research Institute, Durham, North Carolina, USA 2: Mayo Clinic Foundation, Rochester, Minnesota, USA 3: Baylor College of Medicine, Houston, Texas, USA 4: Kaiser-Permanente San Francisco Medical Center, San Francisco, California, USA 5: University of Virginia Health System, Charlottesville, Virginia, USA 6: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Supported by the Agency for Healthcare Research and Quality (AHRQ) Centers for Education and Research on Therapeutics (CERTs) cooperative agreement grant #U18HS10548.; Source Info: Dec2002, Vol. 40 Issue 11, p1895; Subject Term: MEDICAL care; Subject Term: MEDICAL policy; Author-Supplied Keyword: ACC; Author-Supplied Keyword: AHA; Author-Supplied Keyword: American College of Cardiology; Author-Supplied Keyword: American Heart Association; Author-Supplied Keyword: clinical practice guideline; Author-Supplied Keyword: CPG; Author-Supplied Keyword: ESC; Author-Supplied Keyword: European Society of Cardiology; Author-Supplied Keyword: MI; Author-Supplied Keyword: myocardial infarction; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8622662&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahn, Kwang Soo
AU - Park, Ki Sook
AU - Jung, Kyung Mi
AU - Jung, Hai Kwan
AU - Lee, Sun Hee
AU - Chung, Soo Youn
AU - Yang, Ki Hwa
AU - Yun, Yeo Pyo
AU - Pyo, Hyeong Bae
AU - Park, Yong Keun
AU - Yun, Young Won
AU - Kim, Dae Joong
AU - Park, Seung Min
AU - Hong, Jin Tae
T1 - Inhibitory effect of glycolic acid on ultraviolet B-induced c-fos expression, AP-1 activation and p53–p21 response in a human keratinocyte cell line
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/12/05/
VL - 186
IS - 2
M3 - journal article
SP - 125
EP - 135
SN - 03043835
AB - Glycolic acid, an alpha-hydroxy acid derived from fruit and milk sugars, has been commonly used as a cosmetic ingredient since it was known to have photo-protective and anti-inflammatory effects, and anti-oxidant effect in UV-irradiated skin. However, little has been known about the functional role of glycolic acid on UV-induced skin tumorigenesis. We previously found that glycolic acid inhibited UV-induced skin tumor development in hairless mouse. In this study we investigated anti-tumor promoting mechanism of glycolic acid on the UV-induced skin tumor development. The ability of glycolic acid to inhibit the UVB-induced cytotoxicity, apoptosis and expression of apoptosis-regulatory genes (p53 and p21) was examined. We also investigated whether glycolic acid could inhibit UVB-induced alternation of cell cycle, c-fos expression and activation of transcription factor AP-1 in cultured immortalized human keratinocyte HaCaT cells. Glycolic acid treatment attenuated the UVB-induced cell cytotoxicity as well as apoptosis. Glycolic acid also inhibited the UVB-induced expression of c-fos and the activation of transcription factor AP-1, and inhibited mRNA levels of apoptosis-regulatory gene (p53 and p21). These results suggest that glycolic acid may exert the inhibitory effect on the UVB-induced skin tumor development by blocking the UVB-induced of apoptosis and cytotoxicity through inhibition of c-fos expression and activation of AP-1 in addition to the inhibition of p53–p2l response pathway. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROXY acids
KW - APOPTOSIS
KW - Apoptosis
KW - c-fos
KW - Glycolic acid
KW - HaCaT cell
KW - p53/p21
KW - Transcription factors
KW - Ultraviolet B
N1 - Accession Number: 7870036; Ahn, Kwang Soo 1 Park, Ki Sook 1 Jung, Kyung Mi 1 Jung, Hai Kwan 1 Lee, Sun Hee 1 Chung, Soo Youn 1 Yang, Ki Hwa 1 Yun, Yeo Pyo 2 Pyo, Hyeong Bae 2 Park, Yong Keun 3 Yun, Young Won 4 Kim, Dae Joong 4 Park, Seung Min 4 Hong, Jin Tae 2; Email Address: jinthong@cbucc.chungbuk.ac.kr; Affiliation: 1: National Institute of Toxiological Research, Korea Food and Drug Administration, 5, Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea 2: College of Pharmacy, Chungbuk National University, 48, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, South Korea 3: Graduate School of Biotechnology, Korea University, 5, Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea 4: College of Veterinary Medicine, Chungbuk National University, 48, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, South Korea; Source Info: Dec2002, Vol. 186 Issue 2, p125; Subject Term: HYDROXY acids; Subject Term: APOPTOSIS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: Glycolic acid; Author-Supplied Keyword: HaCaT cell; Author-Supplied Keyword: p53/p21; Author-Supplied Keyword: Transcription factors; Author-Supplied Keyword: Ultraviolet B; Number of Pages: 11p; Document Type: journal article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=7870036&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - James, S. Jill
T1 - De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2002/12/10/
VL - 187
IS - 1/2
M3 - Article
SP - 69
SN - 03043835
AB - Previous studies have established that chronic dietary insufficiency of the lipotropic nutrients choline and methionine with or without chemical initiation is hepatocarcinogenic in the rat and certain mouse strains. In the present study, the folate/methyl-deficient model of multistage hepatocarcinogenesis was used to evaluate progressive in vivo changes in p16 promoter methylation in both preneoplastic and tumor tissues. Previous studies using this model have demonstrated stage-dependent alterations in genome-wide and p53 gene-specific methylation. In the present study, we used highly sensitive methylation specific PCR (MSP) to determine time of appearance of methylated sequences within p16 promoter. In addition, methylation-sensitive single nucleotide primer extension methodology was applied to determine methylation status of the remaining CpG sites within amplified methylated alleles. Using this approach, extensive methylation in p16 promoter was found in 100% of tumors, but the pattern of methylation varied depending on tumor type. The incidence and extent of de novo methylation in the CpG island of the p16 promoter increased with tumor progression. To further explore the evolution of p16 gene hypermethylation, we examined the appearance and progression of site-specific de novo methylation during early preneoplasia. Our data show that site-specific de novo methylation of 5′ CpG island of p16 gene precedes tumor development and undergoes dynamic expansion during tumor progression. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - CARCINOGENESIS
KW - DNA methylation
KW - Hepatocarcinogenesis
KW - p16 gene
KW - Rat folate/methyl deficiency
N1 - Accession Number: 7885206; Pogribny, Igor P.; Email Address: ipogribny@nctr.fda.gov James, S. Jill 1; Affiliation: 1: Division of Biochemical Toxicology, Federal Drug Administration, National Center for Toxicological Research, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Dec2002, Vol. 187 Issue 1/2, p69; Subject Term: GENES; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Hepatocarcinogenesis; Author-Supplied Keyword: p16 gene; Author-Supplied Keyword: Rat folate/methyl deficiency; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=7885206&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sriram, K.
AU - Benkovic, S.A.
AU - Miller, D.B.
AU - O’Callaghan, J.P.
T1 - Obesity exacerbates chemically induced neurodegeneration
JO - Neuroscience
JF - Neuroscience
Y1 - 2002/12/16/
VL - 115
IS - 4
M3 - Article
SP - 1335
SN - 03064522
AB - Obesity is a major risk factor associated with a variety of human disorders. While its involvement in disorders such as diabetes, coronary heart disease and cancer have been well characterized, it remains to be determined if obesity has a detrimental effect on the nervous system. To address this issue we determined whether obesity serves as a risk factor for neurotoxicity. Model neurotoxicants, methamphetamine (METH) and kainic acid (KA), which are known to cause selective neurodegeneration of anatomically distinct areas of the brain, were evaluated using an animal model of obesity, the ob/ob mouse. Administration of METH and KA resulted in mortality among ob/ob mice but not among their lean littermates. While METH caused dopaminergic nerve terminal degeneration as indicated by decreased striatal dopamine (49%) and tyrosine hydroxylase protein (68%), as well as an increase in glial fibrillary acidic protein by 313% in the lean mice, these effects were exacerbated under the obese condition (96%, 86% and 602%, respectively). Similarly, a dosage of KA that did not increase glial fibrillary acidic protein in lean mice increased the hippocampal content of this protein (93%) in ob/ob mice. KA treatment resulted in extensive neuronal degeneration as determined by Fluoro-Jade B staining, decreased hippocampal microtubule-associated protein-2 immunoreactivity and increased reactive gliosis in ob/ob mice. The neurotoxic outcome in ob/ob mice remained exacerbated even when lean and ob/ob mice were dosed with METH or KA based only on a lean body mass. Administration of METH or KA resulted in up-regulation of the mitochondrial uncoupling protein-2 to a greater extent in the ob/ob mice, an effect known to reduce ATP yield and facilitate oxidative stress and mitochondrial dysfunction. These events may underlie the enhanced neurotoxicity seen in the obese mice.In summary, our results implicate obesity as a risk factor associated with chemical- and possibly disease-induced neurodegeneration. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY
KW - DISEASES
KW - AD, Alzheimer’s disease
KW - DHBA, dihydroxybenzylamine
KW - DOPAC, dihydroxyphenylacetic acid
KW - EDTA, ethylenediaminetetra-acetate
KW - ELISA, enzyme-linked immunosorbent assay
KW - FITC, fluorescein isothiocyanate
KW - FJB, Fluoro-Jade B
KW - GFAP, glial fibrillary acidic protein
KW - HPLC-EC, high-performance liquid chromatography with electrochemical detection
KW - HVA, homovanillic acid
KW - KA, kainic acid
KW - MAP-2, microtubule-associated protein-2
KW - METH, methamphetamine
KW - MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
KW - PBS-T, phosphate-buffered saline containing 0.5% Triton X-100 solution
KW - PCR, polymerase chain reaction
KW - PD, Parkinson’s disease
KW - RT-PCR, reverse transcription-polymerase chain reaction
KW - SDS, sodium dodecyl sulfate
KW - TH, tyrosine hydroxylase
KW - UCP-2, uncoupling protein-2
N1 - Accession Number: 8547733; Sriram, K. 1 Benkovic, S.A. 1 Miller, D.B. 1 O’Callaghan, J.P.; Email Address: jdo5@cdc.gov; Affiliation: 1: HELD/TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Mailstop L-3014, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Dec2002, Vol. 115 Issue 4, p1335; Subject Term: OBESITY; Subject Term: DISEASES; Author-Supplied Keyword: AD, Alzheimer’s disease; Author-Supplied Keyword: DHBA, dihydroxybenzylamine; Author-Supplied Keyword: DOPAC, dihydroxyphenylacetic acid; Author-Supplied Keyword: EDTA, ethylenediaminetetra-acetate; Author-Supplied Keyword: ELISA, enzyme-linked immunosorbent assay; Author-Supplied Keyword: FITC, fluorescein isothiocyanate; Author-Supplied Keyword: FJB, Fluoro-Jade B; Author-Supplied Keyword: GFAP, glial fibrillary acidic protein; Author-Supplied Keyword: HPLC-EC, high-performance liquid chromatography with electrochemical detection; Author-Supplied Keyword: HVA, homovanillic acid; Author-Supplied Keyword: KA, kainic acid; Author-Supplied Keyword: MAP-2, microtubule-associated protein-2; Author-Supplied Keyword: METH, methamphetamine; Author-Supplied Keyword: MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Author-Supplied Keyword: PBS-T, phosphate-buffered saline containing 0.5% Triton X-100 solution; Author-Supplied Keyword: PCR, polymerase chain reaction; Author-Supplied Keyword: PD, Parkinson’s disease; Author-Supplied Keyword: RT-PCR, reverse transcription-polymerase chain reaction; Author-Supplied Keyword: SDS, sodium dodecyl sulfate; Author-Supplied Keyword: TH, tyrosine hydroxylase; Author-Supplied Keyword: UCP-2, uncoupling protein-2; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106856883
T1 - Responding to disaster.
AU - Martinelli A
Y1 - 2002/12/16/2002 Dec 16
N1 - Accession Number: 106856883. Language: English. Entry Date: 20030808. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Nursing; USA. NLM UID: 9421079.
KW - Disaster Planning
KW - American Nurses Association
KW - Information Resources
KW - Interinstitutional Relations
KW - Pharmacists -- Organizations
KW - United States Department of Health and Human Services
KW - World Wide Web
SP - 6
EP - 6
JO - Nursing Spectrum -- Washington DC & Baltimore Edition
JF - Nursing Spectrum -- Washington DC & Baltimore Edition
JA - NURS SPECTRUM (WASHINGTON DC BALTIMORE)
VL - 12
IS - 25
CY - Falls Church, VA 22042, Illinois
PB - Gannett Healthcare Group
SN - 1098-9153
AD - US Public Health Service Office of Emergency Response, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Xiao, Lihua
AU - Sulaiman, Irshad M.
AU - Ryan, Una M.
AU - Zhou, Ling
AU - Atwill, Edward R.
AU - Tischler, Monica L.
AU - Zhang, Xichen
AU - Fayer, Ronald
AU - Lal, Altaf A.
T1 - Host adaptation and host–parasite co-evolution in Cryptosporidium: implications for taxonomy and public health
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 2002/12/19/
VL - 32
IS - 14
M3 - Article
SP - 1773
SN - 00207519
AB - To assess the genetic diversity and evolution of Cryptosporidium parasites, the partial ssrRNA, actin, and 70 kDa heat shock protein (HSP70) genes of 15 new Cryptosporidium parasites were sequenced. Sequence data were analysed together with those previously obtained from other Cryptosporidium parasites (10 Cryptosporidium spp. and eight Cryptosporidium genotypes). Results of this multi-locus genetic characterisation indicate that host adaptation is a general phenomenon in the genus Cryptosporidium, because specific genotypes were usually associated with specific groups of animals. On the other hand, host–parasite co-evolution is also common in Cryptosporidium, as closely related hosts usually had related Cryptosporidium parasites. Results of phylogenetic analyses suggest that the Cryptosporidium parvum bovine genotype and Cryptosporidium meleagridis were originally parasites of rodents and mammals, respectively, but have subsequently expanded their host ranges to include humans. Understanding the evolution of Cryptosporidium species is important not only for clarification of the taxonomy of the parasites but also for assessment of the public health significance of Cryptosporidium parasites from animals. [Copyright &y& Elsevier]
AB - Copyright of International Journal for Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM
KW - TAXONOMY
KW - Cryptosporidium
KW - Evolution
KW - Host adaptation
KW - Phylogenetics
KW - Public health
KW - Systematics
KW - Taxonomy
N1 - Accession Number: 8575059; Xiao, Lihua 1; Email Address: lax0@cdc.gov Sulaiman, Irshad M. 1 Ryan, Una M. 2 Zhou, Ling 1 Atwill, Edward R. 3 Tischler, Monica L. 4 Zhang, Xichen 5 Fayer, Ronald 6 Lal, Altaf A. 1; Affiliation: 1: Division of Parasitic Diseases, Mail Stop F-12, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4770 Buford Highway, Atlanta, GA 30341, USA 2: State Agricultural Biotechnology Centre, Murdoch University, Murdoch, WA 6150, Australia 3: Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California-Davis, Tulare, CA 93274, USA 4: Benedictine University, Lisle, IL 60532, USA 5: Changchun University of Agriculture and Animal Sciences, Changchun, 130062, People's Republic of China 6: Animal Waste Pathogen Laboratory, Agriculture Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA; Source Info: Dec2002, Vol. 32 Issue 14, p1773; Subject Term: CRYPTOSPORIDIUM; Subject Term: TAXONOMY; Author-Supplied Keyword: Cryptosporidium; Author-Supplied Keyword: Evolution; Author-Supplied Keyword: Host adaptation; Author-Supplied Keyword: Phylogenetics; Author-Supplied Keyword: Public health; Author-Supplied Keyword: Systematics; Author-Supplied Keyword: Taxonomy; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hussain, Saber
AU - Ali, Syed F.
T1 - Zinc potentiates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced dopamine depletion in caudate nucleus of mice brain
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2002/12/19/
VL - 335
IS - 1
M3 - Article
SP - 25
SN - 03043940
AB - Present study describes the effect of zinc (Zn) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine depletion in mice brain. MPTP is a known neurotoxicant primarily causing marked depletion of dopamine (DA) levels in nigrostriatal dopaminergic system. Adult Male C57-mice were intraperitonially injected with 25 mg/kg MPTP in the presence or absence of zinc acetate. Twenty-four hours after treatment animals were sacrificed and DA levels were determined by high performance liquid chromatography in caudate nucleus of control and treated mice. The results showed that there was a marked depletion of DA in MPTP treated mice, whereas no change was observed in DA levels in mice treated with Zn when compare to controls. Interestingly, mice receiving MPTP in conjunction with Zn showed significantly lower DA levels in brain when compare to animals receiving MPTP alone. In summary the data suggest that Zn treatment potentiates depletion of dopamine in MPTP treated mice. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLPHENYLTETRAHYDROPYRIDINE
KW - ZINC
KW - DOPAMINE
KW - 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
KW - Dopamine
KW - Mice
KW - Zinc
N1 - Accession Number: 8549366; Hussain, Saber 1; Email Address: saber.hussain@wpafb.af.mil Ali, Syed F. 1,2; Affiliation: 1: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA Jefferson, AR 72079, USA 2: Department of Biochemistry and Molecular Biology and Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 722, USA; Source Info: Dec2002, Vol. 335 Issue 1, p25; Subject Term: METHYLPHENYLTETRAHYDROPYRIDINE; Subject Term: ZINC; Subject Term: DOPAMINE; Author-Supplied Keyword: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Mice; Author-Supplied Keyword: Zinc; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakab, Robert L.
AU - Bowyer, John F.
T1 - Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke
JO - Brain Research
JF - Brain Research
Y1 - 2002/12/20/
VL - 958
IS - 1
M3 - Article
SP - 52
SN - 00068993
AB - The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects. Here we report a 2-day AMPH treatment paradigm which affected only interneurons in three cortical regions with average or below-average dopamine input. AMPH (six escalating doses/day ranging from 5 to 30 mg/kg for 2 days) was given at 17–18 °C ambient temperature (T) to adult male rats. During the 2-day AMPH treatment, peak body T stayed below 38.9 °C in 40% of the AMPH treated rats. In 60% of the rats, deliberate cooling suppressed (<39.5 °C) or minimized (<40.0 °C) hyperthermia. Escalation of stereotypes to seizure-like behaviors was rare and post-mortem morphological signs of stroke were absent. Neurons labeled with the anionic, neurodegeneration-marker dye Fluoro-Jade (F-J) were seen 1 day after dosing, peaked 3 days later, but were barely detectable 14 days after dosing. Only nonpyramidal neurons in layer IV of the somatosensory barrel cortex and in layer II of the piriform cortex and posterolateral cortical amygdaloid nucleus were labeled with Fluoro-Jade. Isolectin B-labeled activated microglia were only detected in their neighborhood. F-J labeled neurons were extremely rare in cortical regions rich in dopamine (e.g. cingulate cortex), and were absent in cortical regions with no dopamine (e.g. visual cortex). Parvalbumin was seen in some Fluoro-Jade-labeled neurons and parvalbumin immunostaining in local axon plexuses intensified. This AMPH paradigm affected fewer cortical regions, and caused smaller reduction in striatal tyrosine hydroxylase (TH) immunoreactivity than previous 1-day AMPH regimens generating seizures or severe (above 40 °C) hyperthermia. Correlation between peak or mean body T and the extent of neurodegeneration or microgliosis was below statistical significance. Astrogliosis (elevated levels of the astroglia-marker, glial fibrillary acidic protein (GFAP)) was detected in many brain regions. In the striatum and midbrain, F-J labeled neurons and activated microglia were absent, but astrogliosis, decreased TH immunolabel, and swollen TH fibers were detected. In sum, after this AMPH treatment, cortical pyramidal neurons were spared, but astrogliosis was brain-wide and some interneurons and microglia in three cortical regions with average or below-average dopamine input remained sensitive to AMPH exposure. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPHETAMINES
KW - MICROGLIA
KW - NEURONS
KW - 5-HT, serotonin
KW - AMPH, d-amphetamine
KW - CPu, caudate/putamen
KW - F-J, Fluoro-Jade
KW - GABA, gamma-amino butyric acid
KW - GFAP, glial fibrillary acidic protein
KW - METH, methamphetamine
KW - PLCo, posterolateral cortical amygdaloid nucleus
KW - T, temperature
KW - TH, tyrosine hydroxylase
N1 - Accession Number: 8577542; Jakab, Robert L. 1 Bowyer, John F.; Email Address: jbowyer@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR 72079-9502, USA; Source Info: Dec2002, Vol. 958 Issue 1, p52; Subject Term: AMPHETAMINES; Subject Term: MICROGLIA; Subject Term: NEURONS; Author-Supplied Keyword: 5-HT, serotonin; Author-Supplied Keyword: AMPH, d-amphetamine; Author-Supplied Keyword: CPu, caudate/putamen; Author-Supplied Keyword: F-J, Fluoro-Jade; Author-Supplied Keyword: GABA, gamma-amino butyric acid; Author-Supplied Keyword: GFAP, glial fibrillary acidic protein; Author-Supplied Keyword: METH, methamphetamine; Author-Supplied Keyword: PLCo, posterolateral cortical amygdaloid nucleus; Author-Supplied Keyword: T, temperature; Author-Supplied Keyword: TH, tyrosine hydroxylase; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spruill, M. D.
AU - Song, B.
AU - Whong, W.-Z.
AU - Ong, T.
T1 - PROTO-ONCOGENE AMPLIFICATION AND OVEREXPRESSION IN CADMIUM-INDUCED CELL TRANSFORMATION.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2002/12/27/
VL - 65
IS - 24
M3 - Article
SP - 2131
EP - 2144
SN - 15287394
AB - Cadmium (Cd) is an essential material used in the battery, metal-coating, and alloy industries. In addition to these industrial uses, it is also a component of cigarette smoke. Therefore, exposure to cadmium is widespread and presents a considerable health concern. Cadmium is known to be a carcinogen; however, the possible mechanism of carcinogenesis with regards to the activation and inactivation of cancer-related genes has not yet been fully elucidated. In this study, amplification, expression, and point mutation of cancer-related genes associated with Cd-induced cell transformation in BALB/c-3T3 cells were studied. Six proto-oncogenes (K-ras, c-myc, c-fos, c-jun, c-sis, and erbB), as well as the p53 tumor suppressor, were investigated for gene amplification using differential polymerase chain reaction (PCR), while the expression of the proteins produced by these genes was evaluated by Western blot analysis. Point mutations in K-ras and p53 were studied by PCR restriction fragment length polymorphism analysis and DNA sequencing. There were no point mutations observed in codons 12, 13, and 61 of K-ras or in exons 4-10 of p53 and no observed differences in the levels of any of the proteins studied. Among 10 Cd-induced transformed cell lines, significant gene amplification was found for c-myc and c-jun in 50% and 80% of the cell lines, respectively. Chromosome painting was performed to confirm that this amplification was not simply due to additional copies of the chromosomes carrying these oncogenes. In addition, reverse-transcription PCR (RT-PCR) was performed to confirm increased expression of c-myc and c-jun. These results suggest that cell transformation induced by Cd may be attributed, at least in part, to gene amplification of c-myc and c-jun and that some of the Cd-transformed cells may possess neoplastic potential resulting from genomic instability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOGENES
KW - GENE amplification
KW - GENE expression
KW - CELL transformation
N1 - Accession Number: 8798753; Spruill, M. D. 1 Song, B. 1 Whong, W.-Z. 1 Ong, T. 1; Affiliation: 1: Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2002, Vol. 65 Issue 24, p2131; Subject Term: ONCOGENES; Subject Term: GENE amplification; Subject Term: GENE expression; Subject Term: CELL transformation; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/00984100290071379
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sweeney, Carol
AU - Coles, Brian F.
AU - Nowell, Susan
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer
JO - Toxicology
JF - Toxicology
Y1 - 2002/12/27/
VL - 181/182
M3 - Article
SP - 83
SN - 0300483X
AB - Red meats cooked at high temperatures generate mutagenic heterocyclic amines, which undergo metabolic activation by hepatic cytochrome P450 1A2 and N-acetyltransferase-2. A primary detoxification pathway involves glutathione S-transferase A1 (GSTA1), which catalyzes the reduction of the carcinogenic N-acetoxy derivative back to the parent amine. Recently, we described a polymorphism in the GSTA1 proximal promoter; the variant (GSTA1*B) allele significantly lowers enzyme expression. In a case-control study, GSTA1*B/*B genotype was associated with an increased risk of colorectal cancer, particularly among consumers of well-done meat. Dietary nitrosamines, which are bioactivated by CYP2A6, represent another potential etiologic factor for colorectal cancer. CYP2A6 converts the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyluric acid (17U); we investigated CYP2A6 activity using the 17U/17X urinary metabolite ratio from case-control subjects who completed a caffeine phenotype assay. The distribution of CYP2A6 activity was significantly different between CRCa cases and controls, with subjects in the medium and high activity groups having an increased risk (P for trend=0.001). GSTA1 genotype and CYP2A6 phenotype should be evaluated as markers of susceptibility to dietary carcinogens in future studies. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENS
KW - HETEROCYCLIC compounds
KW - MUTAGENS
KW - COLON cancer
KW - Caffeine phenotype
KW - Colorectal cancer
KW - Cytochrome P450 2A6
KW - Glutathione S-transferase A1
N1 - Accession Number: 8793745; Sweeney, Carol 1 Coles, Brian F. 1 Nowell, Susan 2 Lang, Nicholas P. 2,3 Kadlubar, Fred F. 1; Email Address: fkadlubar@nctr.fda.gov; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Central Arkansas Veteran's Health Care System, Little Rock, AR, USA 3: Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Source Info: Dec2002, Vol. 181/182, p83; Subject Term: CARCINOGENS; Subject Term: HETEROCYCLIC compounds; Subject Term: MUTAGENS; Subject Term: COLON cancer; Author-Supplied Keyword: Caffeine phenotype; Author-Supplied Keyword: Colorectal cancer; Author-Supplied Keyword: Cytochrome P450 2A6; Author-Supplied Keyword: Glutathione S-transferase A1; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hattan, David G.
AU - Kahl, Linda S.
T1 - Current developments in food additive toxicology in the USA
JO - Toxicology
JF - Toxicology
Y1 - 2002/12/27/
VL - 181/182
M3 - Article
SP - 417
SN - 0300483X
AB - A recently published proposal (Fed. Reg. 66 (2001) 4706) for mandatory submission of information on all plant-derived bioengineered foods fed to humans or animals will be reviewed. Under this proposal, information such as data on identity, level and function of the introduced substance(s); an estimate of dietary exposure; allergenic potential of the protein; data relevant to other safety issues that may be associated with the substance; selection of a comparable food; historic uses of comparable food; composition and characteristics of bioengineered food versus those of the comparable food should be provided. In addition, characterization of the parent plant; construction of the transformation vector and introduced genetic material along with number of insertion sites and genes; data on the genetic material and any newly inserted genes for antibiotic resistance should be submitted with the notification. The Interagency Coordinating Committee for Validation of Alternative Methods (ICCVAM) was identified by the U.S. Congress as the organization to review and validate new alternative toxicological test methods for 14 U.S. government agencies. Validated and accepted alternative toxicity tests will be incorporated into toxicity testing recommendations for regulatory agencies. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Biotechnology
KW - FOOD additives
KW - TOXICOLOGY
KW - Alternative toxicologic test methods
KW - Biotechnology testing policy
KW - Food additive toxicology
N1 - Accession Number: 8793801; Hattan, David G.; Email Address: dhattan@cfsan.fda.gov Kahl, Linda S. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 200 C. St., S.W., Washington, DC 20204, USA; Source Info: Dec2002, Vol. 181/182, p417; Subject Term: FOOD -- Biotechnology; Subject Term: FOOD additives; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Alternative toxicologic test methods; Author-Supplied Keyword: Biotechnology testing policy; Author-Supplied Keyword: Food additive toxicology; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choi, Don Woong
AU - Kim, Jong Hwan
AU - Cho, So Yean
AU - Kim, Dal Hwan
AU - Chang, Seung Yeup
T1 - Regulation and quality control of herbal drugs in Korea
JO - Toxicology
JF - Toxicology
Y1 - 2002/12/27/
VL - 181/182
M3 - Article
SP - 581
SN - 0300483X
AB - Korea has a great diversity in resources of medicinal plants. The traditional herbal medicines and their preparations have been widely used in Korea as well as in China and Japan for thousands of years. One of the characteristics of Korean herbal medicine preparations is that all the herbal medicines are incorporated into an extractor at the same time and extracted with boiling water during the decoction process. In this process, a variety of interactions between the active components of several herbal medicines may occur. This is the main reason why quality control of oriental herbal drug is more difficult than that of western herbal drug. In this paper, we would like to present an overview of the characteristics of regulation and quality control of herbal medicines in Korea. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBAL medicine
KW - KOREA
KW - Decoction
KW - Korean herbal medicine
KW - Quality control
N1 - Accession Number: 8793826; Choi, Don Woong; Email Address: cdwkje@hanmail.net Kim, Jong Hwan 1 Cho, So Yean 1 Kim, Dal Hwan 1 Chang, Seung Yeup 1; Affiliation: 1: Department of Herbal Medicines Evaluation, Korea Food and Drug Administration, Seoul, 122-704, South Korea; Source Info: Dec2002, Vol. 181/182, p581; Subject Term: HERBAL medicine; Subject Term: KOREA; Author-Supplied Keyword: Decoction; Author-Supplied Keyword: Korean herbal medicine; Author-Supplied Keyword: Quality control; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aboul-Enein, Hassan Y.
AU - Ali, Imran
AU - Hyun, Myung Ho
AU - Cho, Yoo Jae
AU - Jin, Jong Sun
T1 - Effect of acidity on the enantiomeric resolution of thyroxine and tocainide by HPLC on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column
JO - Journal of Biochemical & Biophysical Methods
JF - Journal of Biochemical & Biophysical Methods
Y1 - 2002/12/31/
VL - 54
IS - 1-3
M3 - Article
SP - 407
SN - 0165022X
AB - Enantiomeric resolution of thyroxine and tocainide was achieved on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column. The mobile phases were methanol/water (4:1, v/v) and methanol/water containing 5 mM sulfuric acid (4:1, v/v) for tocainide and thyroxine respectively. The flow rate was 0.5 ml/min. The effect of the acidity on the chiral resolution of these drugs was studied. Detection was at 220 nm for both drugs. The values of α and Rs were 2.08–3.11 and 1.00–2.60, respectively, for thyroxine while the values of α and Rs were 1.13–1.26 and 0.10–1.30, respectively, for tocainide. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biochemical & Biophysical Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROXINE
KW - ENANTIOMERS
KW - (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column
KW - Chiral crown ether
KW - Chiral resolution
KW - Thyroxine
KW - Tocainide
N1 - Accession Number: 8929412; Aboul-Enein, Hassan Y. 1; Email Address: enein@kfshrc.edu.sa Ali, Imran 1 Hyun, Myung Ho 2 Cho, Yoo Jae 2 Jin, Jong Sun 3; Affiliation: 1: Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia 2: Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Pusan 609-735, Republic of Korea 3: Department of Drug Evaluation, Korea Food and Drug Administration, Enpyung-Ku, Seoul 122-704, Republic of Korea; Source Info: Dec2002, Vol. 54 Issue 1-3, p407; Subject Term: THYROXINE; Subject Term: ENANTIOMERS; Author-Supplied Keyword: (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column; Author-Supplied Keyword: Chiral crown ether; Author-Supplied Keyword: Chiral resolution; Author-Supplied Keyword: Thyroxine; Author-Supplied Keyword: Tocainide; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - Gen
ID - 9999-12407-000
AN - 9999-12407-000
AU - Lehman, Anthony F.
AU - Fischer, Ellen P.
AU - Postrado, Leticia
AU - Delahanty, Janine
AU - Johnstone, Bryan M.
AU - Russo, Patricia A.
AU - Crown, William H.
T1 - Schizophrenia Care and Assessment Program Health Questionnaire
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2003///
AD - Lehman, Anthony F., University of Maryland, Department of Psychiatry, 701 West Pratt St., Baltimore, Maryland, United States, 21201
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-12407-000. Acronyms: SCAP-HQ. Partial author list: First Author & Affiliation: Lehman, Anthony F.; University of Maryland, Center for Mental Health Services Research, Baltimore, Maryland, United States. Release Date: 20120910. Correction Date: 20160613. Instrument Type: Inventory/Questionnaire. Test Format: The Schizophrenia Care and Assessment Program Health Questionnaire is administered in 30 minutes or less in a structured, self-report interview format.. Language: English. Constructs: Quality of Care; Classification: Treatment, Rehabilitation, and Therapeutic Processes (7900). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Schizophrenia Care and Assessment Program Health Questionnaire is to assess outcomes of routine care for persons with schizophrenia in service systems.
AB - Description: The Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ; Lehman et al., 2003) was developed to assess outcomes of routine care for persons with schizophrenia in service systems. Candidate items for this structured self-report were drawn from existing measures. Domains covered include disease outcomes (symptoms, subjective medication effects, substance abuse), functional status, health status, quality of life, and public safety. Fifteen scales were derived by factor analysis from 55 outcome items on the SCAP-HQ: psychiatric symptoms, life satisfaction, instrumental activities of daily living, health-related disability, subjective medication side effects, vitality, legal problems, social relations, mental health-related disability, suicidality, drug and alcohol use, daily activities, victimization, violence, and employment. A sample of patients with schizophrenia or schizoaffective disorder completed the SCAP-HQ. For most scales, standard psychometric parameters, including internal consistency and test-retest reliability, convergent validity, and responsiveness to change, were acceptable for application to large sample evaluations of care systems. (PsycTESTS Database Record (c) 2016 APA, all rights reserved)
KW - Health Care Delivery
KW - Schizophrenia Care and Assessment Program Health Questionnaire
KW - Test Development
KW - Treatment Outcomes
KW - Psychometric Properties
U5 - Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ) [Test Development]The Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ): An instrument to assess outcomes of schizophrenia care. (AN: 2003-08619-006 from PsycINFO) Lehman, Anthony F.; Fischer, Ellen P.; Postrado, Leticia; Delahanty, Janine; Johnstone, Bryan M.; Russo, Patricia A.; Crown, William H.; 2003. Source: Schizophrenia Bulletin. 29(2), National Institute of Mental Health, US; 2003; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Sample: Patients with a Diagnosis of Schizophrenia, Schizoaffective Disorder, Or Schizophreniform Disorder Keywords: Health Care Delivery; Schizophrenia Care and Assessment Program Health Questionnaire; Test Development; Treatment Outcomes; Psychometric Properties; Subjects: Health Care Delivery; Schizophrenia; Test Construction; Test Reliability; Test Validity; Treatment Outcomes;
DO - 10.1037/t12407-000
L3 - Full; Full text; 999912407_full_001.pdf
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UR - alehman@psych.umaryland.edu
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 106835771
T1 - Estrogen plus progestin was not effective for long-term secondary prevention of coronary heart disease in postmenopausal women.
AU - Atkins D
Y1 - 2003/01//Jan/Feb2003
N1 - Accession Number: 106835771. Language: English. Entry Date: 20030530. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary; tables/charts. Original Study: Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). (JAMA) 7/3/2002; 288 (1): 49-57. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9104824.
KW - Hormone Replacement Therapy
KW - Estrogens -- Therapeutic Use
KW - Progestational Hormones -- Therapeutic Use
KW - Coronary Disease -- Prevention and Control
KW - Clinical Trials
KW - Prospective Studies
KW - Estrogens -- Administration and Dosage
KW - Estrogens -- Adverse Effects
KW - Progestational Hormones -- Adverse Effects
KW - Medroxyprogesterone -- Administration and Dosage
KW - Treatment Duration
KW - Treatment Outcomes
KW - Coronary Disease -- Mortality
KW - Cardiovascular Diseases -- Epidemiology
KW - Osteoporosis -- Prevention and Control
KW - P-Value
KW - Descriptive Statistics
KW - Confidence Intervals
KW - Postmenopause
KW - Female
KW - Middle Age
KW - Aged
KW - Outpatients
KW - United States
SP - 6
EP - 7
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 138
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 12511118.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106835771&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2003-06578-002
AN - 2003-06578-002
AU - Carver, Karen
AU - Joyner, Kara
AU - Udry, J. Richard
ED - Florsheim, Paul
ED - Florsheim, Paul, (Ed)
T1 - National estimates of adolescent romantic relationships.
T2 - Adolescent romantic relations and sexual behavior: Theory, research, and practical implications.
Y1 - 2003///
SP - 23
EP - 56
CY - Mahwah, NJ, US
PB - Lawrence Erlbaum Associates Publishers
SN - 0-8058-3830-9
AD - Carver, Karen, Indian Health Service, OPH/Statistics Program, 801 Thompson Ave., Ste. 120, Rockville, MD, US, 20852
N1 - Accession Number: 2003-06578-002. Partial author list: First Author & Affiliation: Carver, Karen; Indian Health Service, OPH/Statistics Program, Rockville, MD, US. Release Date: 20031006. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8058-3830-9, Hardcover. Language: English. Major Descriptor: Adolescent Development; Psychosexual Behavior; Relationship Satisfaction; Romance. Minor Descriptor: Health; Social Dating. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 34.
AB - This chapter provides national estimates of the prevalence and characteristics of adolescent romantic relationships using data from the National Longitudinal Study of Adolescent Health (Add Health). The study addresses a number of questions critical to models of adolescent development. The authors review studies concerning the romantic relationships of adolescents, and additionally review studies that consider romantic relationships among adults and friendship among adolescents. Based on this review, they posit expectations for how relationship qualities vary by the sex, age, and race of adolescents. They note, however, that because studies typically focus on Whites, expectations about racial differences are limited. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - romantic relationships
KW - adolescent romance
KW - national estimates
KW - national longitudinal study
KW - adolescent development
KW - relationship qualities
KW - racial differences
KW - adolescent health
KW - normative data
KW - 2003
KW - Adolescent Development
KW - Psychosexual Behavior
KW - Relationship Satisfaction
KW - Romance
KW - Health
KW - Social Dating
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-06578-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Al-Khatib, Sana M.
AU - LaPointe, Nancy M.Allen
AU - Curtis, Lesley H.
AU - Kramer, Judith M.
AU - Swann, Joslyn
AU - Honig, Peter
AU - Califf, Robert M.
T1 - Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000
JO - American Journal of Cardiology
JF - American Journal of Cardiology
Y1 - 2003/01//
VL - 91
IS - 1
M3 - Article
SP - 91
SN - 00029149
N1 - Accession Number: 8724602; Al-Khatib, Sana M. 1; Email Address: alkha001@mc.duke.edu LaPointe, Nancy M.Allen 1 Curtis, Lesley H. 1 Kramer, Judith M. 1 Swann, Joslyn 2 Honig, Peter 2 Califf, Robert M. 1; Affiliation: 1: Duke Center for Education & Research on Therapeutics (CERTs) at the Duke Clinical Research Institute, Durham, North Carolina, USA 2: the US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jan2003, Vol. 91 Issue 1, p91; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graham, David J.
AU - Drinkard, Carol R.
AU - Shatin, Deborah
T1 - Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
Y1 - 2003/01//
VL - 98
IS - 1
M3 - Article
SP - 175
SN - 00029270
AB - : ObjectiveTroglitazone, a thiazolidinedione antidiabetic agent, was withdrawn from the U.S. market in March, 2000, after 94 cases of acute liver failure (ALF) were reported with its use. Based on a literature review, the estimated background rate of hospitalization for idiopathic acute liver injury is 22 per million person-years and for idiopathic ALF, less than 1 per million person-years. This study was conducted to estimate the incidence rates of hospitalized idiopathic acute liver injury and ALF among troglitazone-treated patients.: MethodsAn observational retrospective inception cohort of patients treated with troglitazone was assembled using claims data from a large multistate health care organization. Patients with at least 90 days of health plan enrollment before their first troglitazone prescription between April, 1997 and December, 1998 were enrolled. Hospitalized cases of potential troglitazone-induced acute liver injury or ALF were identified from claims data based on International Classification of Diseases, 9th Revision, coding. Primary medical records were reviewed for case validation, and incidence rates of acute liver injury were calculated using person-years of troglitazone exposure as the denominator.: ResultsA total of 7568 patients contributed 4020 person-years of troglitazone exposure. Of these, five were hospitalized with acute liver injury attributed to the drug and not explained by other causes. Incidence rates (95% CI) per million person-years of acute idiopathic liver injury were as follows: hospitalization (n = 5), 1244 (404, 2900); hospitalized jaundice (n = 4), 995 (271, 2546); and ALF (n = 1), 240 (6.3, 1385).: ConclusionTroglitazone use was associated with a marked increase in risk of hospitalized acute idiopathic liver injury and ALF. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Gastroenterology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - LIVER failure
N1 - Accession Number: 8903825; Graham, David J. 1 Drinkard, Carol R. 2 Shatin, Deborah 2; Affiliation: 1: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 2: Center for Health Care Policy and Research, UnitedHealth Group, Minnetonka, Minnesota, USA; Source Info: Jan2003, Vol. 98 Issue 1, p175; Subject Term: DRUGS; Subject Term: LIVER failure; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - McCAWLEY, MICHAEL
AU - MOYER, ERNEST S.
AU - MARTIN Jr., STEPHEN B.
AU - HORNSBY-MYERS, JENNIFER L.
AU - BERAKIS, MIKE
AU - KENT, MIKE
T1 - Deposited Submicrometer Particulate.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2003/01//
VL - 47
IS - 1
M3 - Letter
SP - 91
EP - 91
SN - 00034878
AB - A letter to the editor is presented in response to the article "Deposited Submicrometer Particulate," by Michael McCawley, Ernest S. Moyer, Stephen B. Martin Jr., Jennifer L. Hornsby-Myers, Mike Berakis and Mike Kent in the September 2002 issue is presented.
KW - Diesel particulate filters
KW - Letters to the editor
KW - greenhouse
KW - hand lance application
KW - malathion
KW - operator exposure
N1 - Accession Number: 44400224; McCAWLEY, MICHAEL 1; MOYER, ERNEST S. 1; MARTIN Jr., STEPHEN B. 1; HORNSBY-MYERS, JENNIFER L. 1; BERAKIS, MIKE 1; KENT, MIKE 1; Affiliations: 1: Department of Health & Human Services, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Jan2003, Vol. 47 Issue 1, p91; Thesaurus Term: Diesel particulate filters; Subject Term: Letters to the editor; Author-Supplied Keyword: greenhouse; Author-Supplied Keyword: hand lance application; Author-Supplied Keyword: malathion; Author-Supplied Keyword: operator exposure; Number of Pages: 1p; Document Type: Letter
L3 - 10.1093/annhyg/meg005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Battles, JB;
T1 - AHRQ patient safety initiatives: Research and reporting
CT - AHRQ patient safety initiatives: Research and reporting
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 2003/01/01/
VL - 38
IS - DEC
SP - PI
EP - 11
AD - AHRQ, John M Eisenberg Bldg,540 Gaither Rd, Rockville, MD 20850, USA jbattles@ahrq.gov
N1 - Accession Number: 40-18477; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Sociology, Economics and Ethics; Institutional Pharmacy Practice
N2 - Many of today's commonplace computerized interventions, such as drug interaction alerts, had their genesis in early AHRQ research initiatives. The development of AHRQ's Patient Safety Indicators describes the steps health information management professionals can take to make a contribution to the national effort of monitoring and preventing medical errors through the application and ongoing refinement of ICD-9-CM and, eventually, ICD-10-CM codes for diagnoses, procedures, and complications. In February 2003 AHRQ's launched an on-line, peer-reviewed, Web-based medical journal - Web M&M. This journal showcases patient safety lessons drawn from actual cases of medical errors. AHRQ and its partner organizations in DHHS, CDC, CMS, and FDA are integrating the federal reporting systems in an integrated form called the Patient Safety Data Network. AHRQ has also been cooperating with the United Kingdom on patient safety activities. These activities have included cooperative research planning, and jointly sponsored research methods workshops This presentation will cover these and other future research initiatives including the DHHS plan to establishing a national, error-reporting program and status of current and pending legislation for event reporting where health care professionals can report mistakes to private groups called "patient safety organizations" (PSO's). Learning Objectives 1. To be able to describe the benefits of using patient safety indicators as a monitoring tool. 2. To be able to implement a activity using the AHRQ Web M&M program to support local patient safety efforts 3. To be able to describe the major areas functions and reporting formats of the Patient Safety Data Network 4. To be able to describe areas in patient safety are the US and UK cooperating 5. To be able to describe the purpose of a patient safety organization (PSO) under new federal legislation. Self-Assessment Questions 1. What are the major areas of research in AHRQ's research portfolio? 2. What are the benefits of using patient safety indicators as a monitoring tool? 3. How can the Web M&M program be used to support local patient safety efforts? 4. In what areas in patient safety are the US and UK cooperating? 5. What is the purpose of a patient safety organization (PSO) under new federal legislation? Answers: 1. AHRQ's Patient Safety Indicators designed to be a means of monitoring and preventing medical errors through the application and ongoing refinement of ICD-9-CM and, eventually, ICD-10-CM codes for diagnoses, procedures, and complications. The PSI are indicators of harm and areas where there are potential problems in patient safety. They are not direct measures of medical error or heath care associated harm. The PSI can be used as part of a comprehensive patient safety program at all level. National, state and local institutional level. 2. AHRQ's - Web M&M is a web-based medical journal that showcases patient safety lessons drawn from actual cases of medical errors. The resource can be used and a stand alone teaching resource or can be used in a group setting. It is ideal for continuing education, graduate training, and staff development. 3. The Patient Safety Data Network is an effort by DHHS to integrate the various reporting systems within the department operated by AHRQ, CDC, CMS, and FDA. Initial efforts will be to develop a common web based user front end for reporting events association with blood products, drugs, devices, infections, ESRD events, and worker safety, and vaccines. 4. The US and UK are cooperating inpatient safety in joint research planning, development of event reporting systems, and sharing of research methods for patient safety. 5. Current legislation pending before Congress would create regional and national Patient Safety Organizations which would receive patient safety information of about events that have occurred in health care facilities and organizations. The information submitted to PSO would be protected from discovery and can not be used in litigation. The PSO would analyze the data and provide feedback to local organizations submitting data. PSO may submit data to the National Patient Safety Data Network for further analysis. The ultimate goal of the current legislation to make patient safety data available for improvement, while protecting the identity of those submitting the data.
KW - Research--errors, medication;
KW - Interventions--errors, medication;
KW - Reports--errors, medication;
KW - Health professions--errors, medication;
KW - Pharmacy, institutional, hospital--errors, medication;
KW - Administration--hospital pharmacy;
KW - ASHP meeting abstracts--errors, medication;
KW - Errors, medication--research;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Johnson, E.L.
AU - Schmidt, W.F.
AU - Emche, S.D.
AU - Mossoba, M.M.
AU - Musser, S.M.
T1 - Kaempferol (rhamnosyl) glucoside, a new flavonol from Erythroxylum coca. var.ipadu
JO - Biochemical Systematics & Ecology
JF - Biochemical Systematics & Ecology
Y1 - 2003/01//
VL - 31
IS - 1
M3 - Article
SP - 59
SN - 03051978
AB - A new flavonol, kaempferol rhamnosyl diglycoside, was isolated from leaf tissue of Amazonian field-grown coca Erythroxylum coca var. ipadu Plowman. The structure of the flavonol has been determined as kaempferol 4′-O-(rhamnosyl)glucoside by spectral analyses. The array of flavonoids present in E. c. var. ipadu currently under cultivation in Colombian fields is indicative of a recent cross, consistent with ancestralship to E. c. var. coca and the flavonol is useful as a chemotaxonomic marker for the taxon. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Systematics & Ecology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVONOIDS
KW - COCA
KW - Amazonian coca
KW - E. c. var. ipadu
KW - Erythroxylum coca var. ipadu
KW - Flavonoids
KW - Flavonol
KW - Glucoside
KW - Kaempferol
KW - Rhamnoside
N1 - Accession Number: 8620248; Johnson, E.L. 1; Email Address: johnsone@ba.ars.usda.gov Schmidt, W.F. 2 Emche, S.D. 3 Mossoba, M.M. 4 Musser, S.M. 4; Affiliation: 1: USDA ARS Alternate Crops and Systems Laboratory, Bldg 001 Rm. 329 BARC-W, 20705-2350 Beltsville, MD, USA 2: USDA Environmental Chemistry Laboratory, Bldg 12, 20705-2350 Beltsville, MD, USA 3: USDA ARS Alternate Crops and Systems Laboratory, Bldg 001 Rm. 332 BARC-W, 20705-2350 Beltsville, MD, USA 4: Food and Drug Administration, Instrumentation and Biophysics Branch, HFS-717 200 C St., S.W., 20204 Washington, DC, USA; Source Info: Jan2003, Vol. 31 Issue 1, p59; Subject Term: FLAVONOIDS; Subject Term: COCA; Author-Supplied Keyword: Amazonian coca; Author-Supplied Keyword: E. c. var. ipadu; Author-Supplied Keyword: Erythroxylum coca var. ipadu; Author-Supplied Keyword: Flavonoids; Author-Supplied Keyword: Flavonol; Author-Supplied Keyword: Glucoside; Author-Supplied Keyword: Kaempferol; Author-Supplied Keyword: Rhamnoside; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0305-1978(02)00071-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coles, Brian F.
AU - Kadlubar, Fred F.
T1 - Detoxification of electrophilic compounds by glutathione S -transferase catalysis: Determinants of individual response to chemical carcinogens and chemotherapeutic drugs?
JO - Biofactors
JF - Biofactors
Y1 - 2003/01//
VL - 17
IS - 1-4
M3 - Article
SP - 115
EP - 130
PB - Wiley-Blackwell
SN - 09516433
AB - The glutathione S-transferases (GSTs) catalyze the GSH-dependent detoxification of reactive electrophiles such as genotoxic chemical carcinogens and cytotoxic chemotherapeutic agents. Allelic polymorphism in the GSTs has been used to investigate the hypothesis that GSTs are involved in susceptibility to human cancers. Such studies have resulted in low penetrance, high prevalence associations between cancer risk and GST polymorphisms. By examination of interindividual variation of GST expression it becomes clear that GST genotype alone is not an accurate predictor of GST expression. GST expression is tissue specific and interindividual variation of expression is at least 7-fold in normal tissues. Thus, populations of the same genotype are actually heterogeneous as regards expression. Similarly, polymorphisms are not effective in all tissues and GST induction is not independent of genotype. Mechanistic models for chemical aspects of colorectal cancer and chemotherapy for breast cancer demonstrate some of the ways by which such interactions can be studied and the potential for future studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biofactors is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - TRANSFERASES
KW - DETOXIFICATION (Substance abuse treatment)
KW - CARCINOGENS
KW - GENETIC polymorphisms
KW - COLON cancer
KW - BREAST cancer
KW - DRUG therapy
N1 - Accession Number: 10388817; Coles, Brian F. 1 Kadlubar, Fred F. 1; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR 72079-9502, USA; Source Info: 2003, Vol. 17 Issue 1-4, p115; Subject Term: GLUTATHIONE; Subject Term: TRANSFERASES; Subject Term: DETOXIFICATION (Substance abuse treatment); Subject Term: CARCINOGENS; Subject Term: GENETIC polymorphisms; Subject Term: COLON cancer; Subject Term: BREAST cancer; Subject Term: DRUG therapy; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang, Isaac
T1 - Finite Element Analysis of Hepatic Radiofrequency Ablation Probes using Temperature-Dependent Electrical Conductivity.
JO - BioMedical Engineering OnLine
JF - BioMedical Engineering OnLine
Y1 - 2003/01//
VL - 2
M3 - Article
SP - 12
EP - 18
PB - BioMed Central
SN - 1475925X
AB - Background: Few finite element models (FEM) have been developed to describe the electric field, specific absorption rate (SAR), and the temperature distribution surrounding hepatic radiofrequency ablation probes. To date, a coupled finite element model that accounts for the temperature-dependent electrical conductivity changes has not been developed for ablation type devices. While it is widely acknowledged that accounting for temperature dependent phenomena may affect the outcome of these models, the effect has not been assessed. Methods: The results of four finite element models are compared: constant electrical conductivity without tissue perfusion, temperature-dependent conductivity without tissue perfusion, constant electrical conductivity with tissue perfusion, and temperature-dependent conductivity with tissue perfusion. Results: The data demonstrate that significant errors are generated when constant electrical conductivity is assumed in coupled electrical-heat transfer problems that operate at high temperatures. These errors appear to be closely related to the temperature at which the ablation device operates and not to the amount of power applied by the device or the state of tissue perfusion. Conclusion: Accounting for temperature-dependent phenomena may be critically important in the safe operation of radiofrequency ablation device that operate near 100°C. [ABSTRACT FROM AUTHOR]
AB - Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FINITE element method
KW - RADIO frequency
KW - ABLATION techniques (Medicine)
KW - ELECTRIC conductivity
KW - ELECTRIC fields
KW - PERFUSION (Physiology)
KW - HEAT transfer
N1 - Accession Number: 28781667; Chang, Isaac 1; Email Address: iac@cdrh.fda.gov; Affiliation: 1: Office of Science and Technology, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville MD USA; Source Info: 2003, Vol. 2, p12; Subject Term: FINITE element method; Subject Term: RADIO frequency; Subject Term: ABLATION techniques (Medicine); Subject Term: ELECTRIC conductivity; Subject Term: ELECTRIC fields; Subject Term: PERFUSION (Physiology); Subject Term: HEAT transfer; Number of Pages: 18p; Illustrations: 8 Diagrams, 5 Charts, 11 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Horn, Wade F.
AD - US Department of Health and Human Services
A2 - Clayton, Obie
A2 - Mincy, Ronald B.
A2 - Blankenhorn, David
T1 - Is It Working? Early Evaluations of Fatherhood-Renewal Programs
T2 - Black fathers in contemporary American society: Strengths, weaknesses, and strategies for change
PB - New York:
PB - Russell Sage Foundation
Y1 - 2003///
SP - 138
EP - 152
N1 - Accession Number: 0786787; Reviewed Book ISBN: 0-87154-161-0; ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200508
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination J15
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Harding, Richard
AU - Stewart, Karen
AU - Marconi, Katherine
AU - O'Neill, Joseph F.
AU - Higginson, Irene J.
T1 - Current HIV/AIDS end-of-life care in sub-Saharan Africa: a survey of models, services, challenges and priorities.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2003/01//
VL - 3
IS - 1
M3 - Article
SP - 33
EP - 6
PB - BioMed Central
SN - 14712458
AB - Background: In response to increased global public health funding initiatives to HIV/AIDS care in Africa, this study aimed to describe practice models, strategies and challenges to delivering end-of-life care in sub-Saharan Africa. Methods: A survey end-of-life care programs was conducted, addressing the domains of service aims and configuration, barriers to pain control, governmental endorsement and strategies, funding, monitoring and evaluation, and research. Both closed and qualitative responses were sought. Results: Despite great structural challenges, data from 48 programs in 14 countries with a mean annual funding of US $374,884 demonstrated integrated care delivery across diverse settings. Care was commonly integrated with all advanced disease care (67%) and disease stages (65% offering care from diagnosis). The majority (98%) provided home-based care for a mean of 301 patients. Ninety-four percent reported challenges in pain control (including availability, lack of trained providers, stigma and legal restrictions), and 77% addressed the effects of poverty on disease progression and management. Although 85% of programs reported Government endorsement, end-of-life and palliative care National strategies were largely absent. Conclusions: The interdependent tasks of expanding pain control, balancing quality and coverage of care, providing technical assistance in monitoring and evaluation, collaborating between donor agencies and governments, and educating policy makers and program directors of end-of-life care are all necessary if resources are to reach their goals. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - HIV infections
KW - AIDS (Disease)
KW - TERMINAL care
KW - PALLIATIVE treatment
N1 - Accession Number: 29973762; Harding, Richard 1; Email Address: richard.harding@kcl.ac.uk Stewart, Karen 2; Email Address: Kstewart@hrsa.gov Marconi, Katherine 3; Email Address: KMarconi@hrsa.gov O'Neill, Joseph F. 4; Email Address: O'NeillJF@State.gov Higginson, Irene J. 1; Email Address: irene.higginson@kcl.ac.uk; Affiliation: 1: Department of Palliative Care & Policy, Guy's King's & St Thomas' School of Medicine, King's College London, UK 2: Office of National AIDS Policy, The White House, Washington DC, USA 3: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Maryland, USA 4: The State Department, Global AIDS Programme, The White House, Washington DC, USA; Source Info: 2003, Vol. 3 Issue 1, p33; Subject Term: PUBLIC health; Subject Term: HIV infections; Subject Term: AIDS (Disease); Subject Term: TERMINAL care; Subject Term: PALLIATIVE treatment; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bobelu, Arlene
AU - Scavini, Marina
AU - Stidley, Christine A.
AU - Shah, Vallabh O.
AU - Albert, Carleton P.
AU - Bobelu, Jeanette
AU - Jamon, Eunice
AU - Natachu, Kathy
AU - Neha, Donica
AU - Waikaniwa, Mildred
AU - Welty, Thomas K.
AU - Zager, Philip G.
AU - Narva, Andrew S.
AU - Tentori, Francesca
AU - Kessler, David S.
AU - MacCluer, Jean W.
T1 - Prevalence of Diabetes Is Higher Among Female than Male Zuni Indians.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2003/01//
VL - 26
IS - 1
M3 - Article
SP - 55
EP - 60
SN - 01495992
AB - OBJECTIVE — Test the hypothesis that diabetes and related risk factors are more common among female than male Zuni Indians. RESEARCH DESIGN AND METHODS We conducted a population-based, crosssectional survey of the Zuni Indians aged ≥5 years. We used households within neighborhood clusters as the sampling frame. We administered a questionnaire, collected blood and urine, and measured height and weight. Self-reported diabetes was used to assess previously diagnosed diabetes. Participants without a prior history of diabetes were classified as having newly diagnosed diabetes if they had HbA[sub 1c] >7.0% or random glucose ≥11.1 mmol/l during the survey. RESULTS The prevalence of previously diagnosed diabetes among Zuni Indians aged ≤5 years (n = 1,503) was higher among female Zuni Indians (16.7% [95% CI 14.1-19.3]) than male Zuni Indians (9.7% [7.4-12.1]) (P < 0.001). The prevalence of newty diagnosed diabetes was similar among female Zuni Indians (2.4% [1.4-3.4]) and male Zuni Indians (2.4% [1.2-3.6]). The prevalence of previously and newly diagnosed diabetes was higher among female Zuni Indians (19.1% [16.4-21.9]) than male Zuni Indians (12.2% [9.5-14.8]) (P < 0.001), The prevalence of obesity was higher among female Zuni Indians (34.3% [30.9-37.7]) than male Zuni Indians (21.5% [18.4-24.7]) (P < 0.001). Obesity was associated with diabetes among female and male Zuni Indians. Physical inactivity was more common among female Zuni Indians (44.2% [40.7-47.8]) than male Zuni Indians (35.1% [31.5-38.7]) (P < 0.001). However, physical inactivity was not associated with diabetes among either female or mate Zuni Indians. Gestational diabetes was a risk factor among female Zuni Indians. CONCLUSIONS — Among the Zuni Indians, the prevalence of diabetes was 57% higher among female than male members of the population. Culture, tradition, and lifestyle differences may contribute to the higher prevalence of diabetes and obesity among female Zuni Indians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - ZUNI (North American people)
KW - DISEASES
N1 - Accession Number: 8794187; Bobelu, Arlene 1 Scavini, Marina 1,2 Stidley, Christine A. 1,3 Shah, Vallabh O. 4 Albert, Carleton P. 4 Bobelu, Jeanette 4 Jamon, Eunice 4 Natachu, Kathy 4 Neha, Donica 4 Waikaniwa, Mildred 4 Welty, Thomas K. 4 Zager, Philip G. 4; Email Address: pzag@unm.edu Narva, Andrew S. 5 Tentori, Francesca 4,6 Kessler, David S. 7 MacCluer, Jean W. 8; Affiliation: 1: Dialysis Clinic, Inc., Albuquerque, New Mexico 2: H. San Raffaele Scientific Institute, Milan, Italy 3: Department of Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico 4: Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 5: Kidney Disease Program, Indian Health Service, Albuquerque, New Mexico 6: Universita' degli Studi di Milano, Scuola di Specializzazione in Nefrologia, Milan, Italy 7: Zuni Indian Hospital, Zuni Pueblo, New Mexico 8: Southwest Foundation for Biomedical Research, San Antonio, Texas; Source Info: Jan2003, Vol. 26 Issue 1, p55; Subject Term: DIABETES; Subject Term: ZUNI (North American people); Subject Term: DISEASES; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 5281
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sama, Susan R.
AU - Hunt, Phillip R.
AU - Cirillo, C. I. H. Priscilla
AU - Marx, Arminda
AU - Rosiello, Richard A.
AU - Henneberger, Pauk K.
AU - Milton, Donald K.
T1 - A longitudinal study of adult-onset asthma incidence among HMO members.
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
Y1 - 2003/01//
VL - 2
M3 - Article
SP - 10
EP - 9
PB - BioMed Central
SN - 1476069X
AB - Background: HMO databases offer an opportunity for community based epidemiologic studies of asthma incidence, etiology and treatment. The incidence of asthma in HMO populations and the utility of HMO data, including use of computerized algorithms and manual review of medical charts for determining etiologic factors has not been fully explored. Methods: We identified adult-onset asthma, using computerized record searches in a New England HMO. Monthly, our software applied exclusion and inclusion criteria to identify an "at-risk" population and "potential cases". Electronic and paper medical records from the past year were then reviewed for each potential case. Persons with other respiratory diseases or insignificant treatment for asthma were excluded. Confirmed adult-onset asthma (AOA) cases were defined as those potential cases with either new-onset asthma or reactivated mild intermittent asthma that had been quiescent for at least one year. We validated the methods by reviewing charts of selected subjects rejected by the algorithm. Results: The algorithm was 93 to 99.3% sensitive and 99.6% specific. Sixty-three percent (n = 469) of potential cases were confirmed as AOA. Two thirds of confirmed cases were women with an average age of 34.8 (SD 11.8), and 45% had no evidence of previous asthma diagnosis. The annualized monthly rate of AOA ranged from 4.1 to 11.4 per 1000 at-risk members. Physicians most commonly attribute asthma to infection (59%) and allergy (14%). New-onset cases were more likely attributed to infection, while reactivated cases were more associated with allergies. Medical charts included a discussion of work exposures in relation to asthma in only 32 (7%) cases. Twenty-three of these (72%) indicated there was an association between asthma and workplace exposures for an overall rate of work-related asthma of 4.9%. Conclusion: Computerized HMO records can be successfully used to identify AOA. Manual review of these records is important to confirm case status and is useful in evaluation of provider consideration of etiologies. We demonstrated that clinicians attribute most AOA to infection and tend to ignore the contribution of environmental and occupational exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASTHMA
KW - HEALTH maintenance organizations
KW - DATABASES
KW - DISEASES -- Causes & theories of causation
KW - ALGORITHMS
KW - NEW England
N1 - Accession Number: 28742626; Sama, Susan R. 1; Email Address: ssama@hsph.harvard.edu Hunt, Phillip R. 1; Email Address: prhunt@hsph.harvard.edu Cirillo, C. I. H. Priscilla 2; Email Address: priscilla.cirillo@fallonclinic.com Marx, Arminda 1; Email Address: mmarx@hsph.harvard.edu Rosiello, Richard A. 3; Email Address: richard.rosiello@fallon-clinic.com Henneberger, Pauk K. 4; Email Address: pkh0@cdc.gov Milton, Donald K. 1,5; Email Address: dmiltion@hsph.harvard.edu; Affiliation: 1: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA 2: Research Department, Fallon Clinic, Worcester, MA; USA 3: Department of Pulmonary and Critical Care Medicine, Fallon Clinic, Worcester, MA, USA 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA 5: Department of Occupational Medicine, Fallon Clinic, Worcester, MA, USA; Source Info: 2003, Vol. 2, p10; Subject Term: ASTHMA; Subject Term: HEALTH maintenance organizations; Subject Term: DATABASES; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: ALGORITHMS; Subject Term: NEW England; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 9p; Illustrations: 7 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mohamadi, Sarkar
AU - Unyime, Nseyo
AU - Bao-Zhen, Zhong
T1 - Effect of pH on mutagenicity of urine from smokers and nonsmokers
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2003/01//
VL - 13
IS - 1
M3 - Article
SP - 21
SN - 13826689
AB - Cigarette smoking is a major risk factor for bladder cancer. Some chemicals from cigarette smoke e.g. aromatic amines, are metabolized in the liver and excreted in urine as either glucuronide or acetyl conjugates. These metabolites undergo pH mediated activation to reactive nitreneum ions that may lead to DNA adducts, initiating bladder tumorigenesis in some smokers. We hypothesize that changing the pH of smokers urine will impact the mutagenic outcome of these metabolites. Overnight samples were collected from smokers (n=11) and nonsmokers (n=11) and stored at −70 °C. Each urine sample was adjusted to neutral (7.0), basic (8.2) and acidic (5.5) pH. Mutagenic activity was assessed with the Ames test utilizing the Salmonella Typhimurium strain YG1024 microsuspension assay. Urine from smokers was significantly mutagenic compared with nonsmokers (P<0.001). In both the groups, there was no difference between urine adjusted at different pH (P>0.05). We conclude that changing the pH of smokers urine might not affect their subsequent risk for bladder cancer. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tobacco -- Physiological effect
KW - Bladder cancer
KW - Glucuronides
KW - Cigarette smoke
KW - Effect of pH
KW - Smokers
N1 - Accession Number: 8549635; Mohamadi, Sarkar 1; Email Address: masarkar@vcu.edu; Unyime, Nseyo 2; Bao-Zhen, Zhong 3; Affiliations: 1: School of Pharmacy at MCV Campus, Virginia Commonwealth University, Smith Building, Room 356C, 410 N 12th Street, Richmond, VA 23298-0533, USA; 2: VCU Division of Urology, School of Medicine, Richmond, VA 23298, USA; 3: National Institute of Occupational Safety and Health, Morgantown, WV 25505, USA; Issue Info: Jan2003, Vol. 13 Issue 1, p21; Subject Term: Tobacco -- Physiological effect; Subject Term: Bladder cancer; Subject Term: Glucuronides; Author-Supplied Keyword: Cigarette smoke; Author-Supplied Keyword: Effect of pH; Author-Supplied Keyword: Smokers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106870193
T1 - Review: 'Scared Straight' and other juvenile awareness programmes increase criminal behaviour.
AU - Mueller D
Y1 - 2003/01//
N1 - Accession Number: 106870193. Language: English. Entry Date: 20030926. Revision Date: 20150820. Publication Type: Journal Article; abstract; commentary; tables/charts. Original Study: Petrosino A, Turpin-Petrosino C, Buehler J. 'Scared straight' and other juvenile awareness programs for preventing juvenile delinquency. Cochrane Database Syst Rev 2002; (2):CD002796 (latest version 27 Feb 2002). Journal Subset: Core Nursing; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9815947.
KW - Juvenile Delinquency -- Prevention and Control
KW - Juvenile Offenders
KW - Adolescence
KW - Clinical Trials
KW - Female
KW - Juvenile Delinquency -- Trends
KW - Male
KW - Systematic Review
SP - 12
EP - 12
JO - Evidence Based Nursing
JF - Evidence Based Nursing
JA - EVID BASED NURS
VL - 6
IS - 1
PB - BMJ Publishing Group
AB - QUESTION: In children who have been, or are at risk of being, adjudicated or convicted by a juvenile court, do programmes using organised prison visits designed to deter criminal behaviour (eg, 'Scared Straight' programme) reduce offending activity?Data sourcesStudies were identified by handsearching 29 criminology or social science journals; searching 16 electronic databases (including the trial registers of the Cochrane Collaboration and the Campbell Collaboration); scanning references in relevant reviews, bibliographies, books, articles, and other documents; and contacting experts in the field.Study selectionPublished or unpublished studies were selected if they were randomised or quasi-randomised controlled trials, the intervention included a visit to prison for children /= 1 outcome assessed subsequent offending behaviour. Studies with overlapping samples of adolescents and young adults were included.Data extractionData were extracted on participants, length of follow up, study design, intervention, and outcomes. Authors were contacted for missing data. The quality of studies was assessed. Data were pooled using both random and fixed effects models.Main results9 studies (8 randomised controlled trials) met the selection criteria. The mean age of participants ranged from 15-17 years. Only 1 study included girls. Follow up ranged from 3-24 months. None of the 9 studies showed a benefit for 'Scared Straight' or other juvenile awareness programmes. When results for the 7 studies reporting reoffence data for each group were combined, juvenile awareness programmes led to an increase in criminal behaviour relative to no treatment (table); this effect was present with both random and fixed effects models. The effect was slightly smaller when a trial with randomisation problems was removed; the results were similar when 1 study with potential for high attrition was removed from the analysis (table).ConclusionIn children who have been, or are at risk of being, adjudicated or convicted by juvenile courts, 'Scared Straight' and other juvenile awareness program increase criminal behaviour.
SN - 1367-6539
AD - Program Manager, Healthy Lifestyles and Youth Branch, City of Hamilton Social and Public Health Service Department, Hamilton, Ontario, Canada
U2 - PMID: 12546030.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Risitano, Antonio M.
AU - Holada, Karel
AU - Chen, Guibin
AU - Simak, Jan
AU - Vostal, Jaroslav G.
AU - Young, Neal S.
AU - Maciejewski, Jaroslaw P.
T1 - CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrP c)
JO - Experimental Hematology
JF - Experimental Hematology
Y1 - 2003/01//
VL - 31
IS - 1
M3 - Article
SP - 65
SN - 0301472X
AB - : ObjectiveCellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI)-anchored protein (GPI-AP) constitutively expressed by neurons but also in hematopoietic cells. In trasmissible spongiform encephalopathies, the protease-resistant form of prion (PrP s c) converts the host PrPc into the pathologic form. We have investigated PrPc expression in hematopoietic cells from paroxysmal nocturnal hemoglobinuria (PNH). In this disease, due to somatic mutations in PIG-A gene, biosynthesis of the (GPI)-anchor is impaired and affected cells lack membrane expression of all GPI-AP.: MethodsNormal and PNH hematopoietic progenitors and paired wild-type (WT) and PIG-A mutant cell lines were used for analysis of intracellular and surface PrPc expression using flow cytometry and Western blot.: ResultsBy flow cytometry, PrPc was constitutively present on normal CD34+ cells, including more immature CD38dim cells, as well as hematopoietic cell lines. Similar results were obtained in purified CD34+. Phospholipase C treatment confirmed that PrPc was expressed on the membrane via the GPI-anchor. In PNH patients, GPI-AP-deficient CD34+ cells lacked PrPc membrane expression. PIG-A-mutated cell lines (Jurkat, K562, CEBV, AEBV), in contrast to their normal counterparts, did not express surface PrPc. However, we detected intracellular PrPc at approximately equivalent levels in both normal and PIG-A-mutated cells using intracellular flow cytometry and Western blotting.: ConclusionCells and cell lines with PNH phenotype together with their normal counterparts may be a suitable system to explore the function of membrane PrPc in the hematopoietic system. Conversely, PrPc is a good model to elucidate the fate of GPI-AP in PIG-A-deficient cells. [Copyright &y& Elsevier]
AB - Copyright of Experimental Hematology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - HEMATOPOIETIC stem cells
KW - PAROXYSMAL hemoglobinuria
N1 - Accession Number: 8930116; Risitano, Antonio M. 1 Holada, Karel 2 Chen, Guibin 1 Simak, Jan 2 Vostal, Jaroslav G. 2 Young, Neal S. 1 Maciejewski, Jaroslaw P. 1; Email Address: maciejj@cc.ccf.org; Affiliation: 1: Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md., USA 2: Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Md., USA; Source Info: Jan2003, Vol. 31 Issue 1, p65; Subject Term: PROTEINS; Subject Term: HEMATOPOIETIC stem cells; Subject Term: PAROXYSMAL hemoglobinuria; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Horn, Wade F.
AD - US Department of Health and Human Services
A2 - Besharov, Douglas J.
T1 - Fatherhood, Cohabitation, and Marriage
T2 - Family and child well-being after welfare reform
PB - New Brunswick, N.J. and London:
PB - Transaction
Y1 - 2003///
SP - 129
EP - 144
N1 - Accession Number: 0803633; Reviewed Book ISBN: 0-7658-0188-4; 0-7658-0845-5; Keywords: Marriage; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200511
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Demographic Economics: Public Policy J18
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Isaacs, Julia B.
AD - US Department of Health and Human Services
A2 - Besharov, Douglas J.
T1 - Mothers' Work and Child Care
T2 - Family and child well-being after welfare reform
PB - New Brunswick, N.J. and London:
PB - Transaction
Y1 - 2003///
SP - 247
EP - 257
N1 - Accession Number: 0803641; Reviewed Book ISBN: 0-7658-0188-4; 0-7658-0845-5; Keywords: Child; Mothers; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200511
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
KW - Fertility; Family Planning; Child Care; Children; Youth J13
KW - Economics of Gender; Non-labor Discrimination J16
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Winstead, Don
AU - McCormick, Ann
AD - US Department of Health and Human Services
AD - US Department of Health and Human Services
A2 - Besharov, Douglas J.
T1 - Family and Child Well-Being after Welfare Reform: Activities of the U.S. Department of Health and Human Services
T2 - Family and child well-being after welfare reform
PB - New Brunswick, N.J. and London:
PB - Transaction
Y1 - 2003///
SP - 259
EP - 278
N1 - Accession Number: 0803642; Reviewed Book ISBN: 0-7658-0188-4; 0-7658-0845-5; Keywords: Welfare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200511
KW - National Government Expenditures and Welfare Programs H53
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
ID - 2003-07189-003
AN - 2003-07189-003
AU - Zitzow, Darryl
ED - Shaffer, Howard J.
ED - Hall, Matthew N.
ED - Vander Bilt, Joni
ED - George, Elizabeth
ED - Shaffer, Howard J., (Ed)
ED - Hall, Matthew N., (Ed)
ED - Vander Bilt, Joni, (Ed)
ED - George, Elizabeth, (Ed)
T1 - American Indian gaming.
T2 - Futures at stake: Youth, gambling, and society.
Y1 - 2003///
SP - 39
EP - 48
CY - Reno, NV, US
PB - University of Nevada Press
SN - 0-87417-368-X
N1 - Accession Number: 2003-07189-003. Partial author list: First Author & Affiliation: Zitzow, Darryl; Indian Health Service, Bemidji Area Offices, MN, US. Release Date: 20031110. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-87417-368-X, Hardcover. Language: English. Major Descriptor: American Indians; Economic Development; Gambling; Pathological Gambling. Minor Descriptor: Economics; Sociocultural Factors. Classification: Recreation & Leisure (3740). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 10.
AB - This chapter discusses the nationwide explosion of Indian gaming since the establishment of the Indian Gaming Regulatory Act (IRGA) of 1988 (Public Law 100-497 25 USC). The intention was to promote 'tribal economic development, tribal self-sufficiency, strong tribal governments' the the protection of American Indian gaming rights. In this regard, the author examines positive consequences of gaming for American Indians, its negative consequences, the risk factors found in compulsive gambling research in this population, and prevalence findings in this research. Also, flaws in the current research are discussed, as are recommendations for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indians
KW - economic development
KW - compulsive gambling
KW - gambling research
KW - gaming
KW - 2003
KW - American Indians
KW - Economic Development
KW - Gambling
KW - Pathological Gambling
KW - Economics
KW - Sociocultural Factors
KW - 2003
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
AU - Valentine, Nicole B.
AU - De Silva, Amala
AU - Kawabata, Kei
AU - Darby, Charles
AU - Murray, Christopher J. L.
AU - Evans, David B.
T1 - Chapter 43: HEALTH SYSTEM RESPONSIVENESS: CONCEPTS, DOMAINS AND OPERATIONALIZATION.
JO - Health Systems Performance Assessment
JF - Health Systems Performance Assessment
Y1 - 2003/01//
M3 - Book Chapter
SP - 573
EP - 596
SN - 9789241562454
AB - Chapter 43 of the book "Health Systems Performance Assessment" is presented. The chapter evaluates a population's experience with health services in other regions. It defines the concept of responsiveness, and describes its evolution and how it relates to and differs from the concepts of patient satisfaction and quality of care. It describes several domains which together capture the notion of the responsiveness of the health system. It concludes with a discussion on some of the continued challenges to capturing and measuring responsiveness.
KW - PATIENT satisfaction
KW - MEDICAL care -- Evaluation
KW - ATTITUDES toward health
KW - HEALTH services accessibility
KW - HEALTH
N1 - Accession Number: 26367379; Valentine, Nicole B. De Silva, Amala 1 Kawabata, Kei Darby, Charles 2 Murray, Christopher J. L. Evans, David B.; Affiliation: 1: Department of Economics, University of Colombo, Colombo, Sri Lanka 2: Social Science Administrator Agency for Healthcare Research and Quality, 540 Gaither Road Rockville, Maryland 20850, United States of America; Source Info: 2003, p573; Subject Term: PATIENT satisfaction; Subject Term: MEDICAL care -- Evaluation; Subject Term: ATTITUDES toward health; Subject Term: HEALTH services accessibility; Subject Term: HEALTH; Number of Pages: 24p; Document Type: Book Chapter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106833728
T1 - Federal initiatives: the Agency for Healthcare Research and Quality supports an array of IT initiatives to improve healthcare quality.
AU - Ortiz E
Y1 - 2003/01//2003 Jan
N1 - Accession Number: 106833728. Language: English. Entry Date: 20030523. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Computer/Information Science; Health Services Administration; USA. NLM UID: 9004557.
KW - United States Agency for Healthcare Research and Quality
KW - Organizational Objectives
KW - Patient Safety
KW - Biological Warfare
SP - 49
EP - [52]
JO - Healthcare Informatics
JF - Healthcare Informatics
JA - HEALTHC INFORM
VL - 20
IS - 1
CY - New York, New York
PB - Vendome Group LLC
SN - 1050-9135
AD - Senior Service Fellow, Center for Primary Care Research, Agency for Healthcare Research and Quality, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kelley, Edward
AU - Kelley, Allison Gamble
AU - Simpara, Cheick H. T.
AU - Sidibé, Ousmane
AU - Makinen, Marty
T1 - The impact of self-assessment on provider performance in Mali.
JO - International Journal of Health Planning & Management
JF - International Journal of Health Planning & Management
Y1 - 2003/01//
VL - 18
IS - 1
M3 - Article
SP - 41
EP - 48
SN - 07496753
N1 - Accession Number: 64206798; Kelley, Edward 1; Kelley, Allison Gamble 2; Simpara, Cheick H. T. 3; Sidibé, Ousmane 3; Makinen, Marty 2; Affiliations: 1: Agency for Health Research and Quality, US Department of Health and Human Services, Rockville, MD, USA; 2: Partners for Health Reform Project Plus, Bethesda, MD, USA; 3: Partners for Health Reform Project Plus, Bamako, Mali; Issue Info: Jan2003, Vol. 18 Issue 1, p41; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/hpm.688
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=64206798&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Ahmad, Syed Rizwanuddin
T1 - Adverse Drug Event Monitoring at the Food and Drug Administration.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2003/01//
VL - 18
IS - 1
M3 - Article
SP - 57
EP - 60
SN - 08848734
AB - The Food and Drug Administration (FDA) is responsible not only for approving drugs but also for monitoring their safety after they reach the market. The complete adverse event profile of a drug is not known at the time of approval because of the small sample size, short duration, and limited generalizability of pre-approval clinical trials. This report describes the FDA's postmarketing surveillance system, to which many clinicians submit reports of adverse drug events encountered while treating their patients. Despite its limitations, the spontaneous reporting system is an extremely valuable mechanism by which hazards with drugs that were not observed or recognized at the time of approval are identified. Physicians are strongly encouraged to submit reports of adverse outcomes with suspect drugs to the FDA, and their reports make a difference. The FDA is strengthening its postmarketing surveillance with access to new data sources that have the potential to further improve the identification, quantification, and subsequent management of drug risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Side effects
KW - adverse drug events
KW - drug withdrawals
KW - Food and Drug Administration (FDA)
KW - MedWatch
KW - postmarketing surveillance
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 8875461; Ahmad, Syed Rizwanuddin 1; Affiliation: 1: Received from the Division of Drug Risk Evaluation, Office of Drug Safety, Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, Md.; Source Info: Jan2003, Vol. 18 Issue 1, p57; Subject Term: DRUGS -- Side effects; Author-Supplied Keyword: adverse drug events; Author-Supplied Keyword: drug withdrawals; Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: MedWatch; Author-Supplied Keyword: postmarketing surveillance; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Document Type: Article
L3 - 10.1046/j.1525-1497.2003.20130.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106821880
T1 - Implications of effects in placebo groups.
AU - Temple RJ
Y1 - 2003/01//
N1 - Accession Number: 106821880. Language: English. Entry Date: 20031205. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: Chvetzoff G, Tannock IF. Placebo effects in oncology. (J NATL CANCER INST) Jan2003; 95 (1): 19-29. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503089.
KW - Placebo Effect
KW - Neoplasms -- Drug Therapy
KW - Clinical Trials
SP - 2
EP - 3
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
JA - J NATL CANCER INST
VL - 95
IS - 1
PB - Oxford University Press / USA
SN - 0027-8874
AD - Center for Drug Evaluation and Research, 5600 Fishers Lane, HFD-40, Rockville, MD 20857; temple@cder.fda.gov
U2 - PMID: 12509388.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106816372
T1 - Use of the health care for the homeless program services and other health care services by homeless adults.
AU - Han B
AU - Wells BL
AU - Taylor AM
Y1 - 2003/01//1/1/2003
N1 - Accession Number: 106816372. Language: English. Entry Date: 20030321. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. NLM UID: 9103800.
KW - Health Services for the Indigent -- Utilization
KW - Homeless Persons
KW - Primary Health Care -- Utilization
KW - Government Programs
KW - Community Programs
KW - Descriptive Statistics
KW - Logistic Regression
KW - Dental Care -- Utilization
KW - Odds Ratio
KW - Confidence Intervals
KW - Health Services Accessibility
KW - Sampling Methods
KW - Interviews
KW - Communities
KW - Connecticut
KW - New Jersey
KW - Preventive Health Care -- Utilization
KW - Pennsylvania
KW - Rhode Island
KW - Emergency Care -- Utilization
KW - Health Status
KW - Insurance, Health
KW - Chi Square Test
KW - Analysis of Variance
KW - Post Hoc Analysis
KW - Data Analysis Software
KW - Female
KW - Male
KW - Adult
KW - Age Factors
KW - Self Report
KW - Human
SP - 87
EP - 99
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 14
IS - 1
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - This study examined factors associated with the use of the Health Care for the Homeless Program and other health care services by homeless adults. A total of 941 homeless adults were identified in 52 soup kitchens in U.S. communities. Descriptive statistics and logistic regression models were applied. Among homeless adults, having dental problems was the most robust factor associated with their use of Health Care for the Homeless Program services (odds ratio [OR] = 2.50, 95 percent confidence interval [CI] = 1.44-4.32). Among homeless adults who did not visit Health Care for the Homeless Program services during last six months, the number of emergency room visits was the most powerful factor associated with their use of other health care services (OR = 1.15, 95 percent CI = 1.05-1.26). The results of the study can help health care providers better serve homeless adults to meet their health needs.
SN - 1049-2089
AD - Senior Staff Fellow, Special Populations Research Branch, Division of Programs for Special Populations, Bureau of Primary Health Care, Health Resources and Services Administration, U.S. Department of Health and Human Services, Bethesda, MD 20814
U2 - PMID: 12613070.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106816048
T1 - Implementing program evaluation and accountability for population health: progress of a national diabetes control effort.
AU - Safran MA
AU - Mukhtar Q
AU - Murphy DL
Y1 - 2003/01//Jan/Feb2003
N1 - Accession Number: 106816048. Language: English. Entry Date: 20030321. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Program Evaluation -- Methods
KW - Accountability -- Methods
KW - Public Health
KW - Diabetes Mellitus -- Prevention and Control -- United States
KW - National Health Programs -- Evaluation
KW - Program Evaluation -- Standards
KW - Paradigms
KW - Diabetes Mellitus -- Epidemiology
KW - Organizational Objectives
KW - Health Status Indicators
KW - Models, Theoretical
KW - Preventive Health Care
KW - Change Management
KW - United States
KW - Centers for Disease Control and Prevention (U.S.)
SP - 58
EP - 65
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 9
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - Commander, U.S. Public Health Service Commissioned Corps, Centers for Disease Control and Prevention (CDC), Atlanta, GA
U2 - PMID: 12552931.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Davis, Clare
AU - Heath, Alan
AU - Best, Susan
AU - Hewlett, Indira
AU - Lelie, Nico
AU - Schuurman, Rob
AU - Holmes, Harvey
T1 - Calibration of HIV-1 working reagents for nucleic acid amplification techniques against the 1st international standard for HIV-1 RNA
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2003/01//
VL - 107
IS - 1
M3 - Article
SP - 37
SN - 01660934
AB - Many laboratories use working reagents/run controls to monitor the performance of their nucleic acid amplification techniques (NAT) for the measurement of HIV-1 RNA. A collaborative study was carried out in order to calibrate seven internationally available working reagents, QC105 (National Serology Reference Laboratory [NRL], Australia), B5 and B10 (Center for Biological Evaluation and Research [CBER], USA), Pelispy (Central Laboratory of the Netherlands Blood Transfusion Service [CLB], The Netherlands), PWS-1 and PWS-3 (National Institute for Biological Standards and Control [NIBSC], UK) and IRC (Virology Networks [VN], The Netherlands) against the 1st International Standard for HIV-1 RNA (code 97/656). Twenty-one laboratories from 12 different countries participated in the collaborative study and from the results it was determined that QC105 contained 4.0 log10 International Units (IU)/ml, B5 2.2 log10 IU/ml, B10 3.8 log10 IU/ml, Pelispy 4.4 log10 IU/ml, PWS-1 3.6 log10 IU/ml, PWS-3 2.7 log10 IU/ml and IRC 4.3 log10 IU/ml. The seven working reagents calibrated in this international study may be used to validate and standardise the large number of qualitative and quantitative, commercial and in-house NAT assays that are currently being applied in the fields of blood safety and patient management. They will also help laboratories to comply with the sensitivity requirements that may be brought in by the regulatory authorities and may contribute to further harmonisation of guidelines on NAT published by organisations such as the European Medicines Evaluation Agency (EMEA), Paul–Ehrlich Institute and CBER, FDA. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - RNA
KW - CHEMICAL tests & reagents
KW - Calibration
KW - HIV-1 RNA
KW - International Standard
KW - NAT
KW - Working reagents
N1 - Accession Number: 8546124; Davis, Clare 1 Heath, Alan 2 Best, Susan 3 Hewlett, Indira 4 Lelie, Nico 5 Schuurman, Rob 6 Holmes, Harvey 1; Email Address: hholmes@nibsc.ac.uk; Affiliation: 1: Division of Retrovirology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK 2: Division of Informatics, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK 3: National Serology Reference Laboratory, 4th Floor, Healy Building, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia 4: Center for Biological Evaluation and Research, Food and Drug Administration, Building 29a, Room 2d-16, Rockville, Bethesda, MD 20852, USA 5: VQC Laboratory, Sanquin-CLB Diagnostics Division, Jan Steenstraat 1, Alkmaar 1867 CT, The Netherlands 6: Department of Virology, University Hospital Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Source Info: Jan2003, Vol. 107 Issue 1, p37; Subject Term: HIV (Viruses); Subject Term: RNA; Subject Term: CHEMICAL tests & reagents; Author-Supplied Keyword: Calibration; Author-Supplied Keyword: HIV-1 RNA; Author-Supplied Keyword: International Standard; Author-Supplied Keyword: NAT; Author-Supplied Keyword: Working reagents; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106626797
T1 - Levels of liability: it's not just the physician anymore.
AU - Weaver JD
Y1 - 2003/01//
N1 - Accession Number: 106626797. Language: English. Entry Date: 20050506. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; legal case. Journal Subset: Biomedical; Peer Reviewed; USA. Legal Case: Ramsey v. Physician's Memorial Hospital, Inc., 373 A.2d 26 (Md. 1977); Daniel v. St. Francis Cabrini Hospital of Alexandria, Inc., 415 So.2d 586 (La. 1982); Payne v. Garvey, 142 S.E.2d 159 (N.C. 1965); Parks v. Perry, 314 S.E.2d 287 (N.C. 1984); St. Paul Medical Center v. Cecil, 842 S.W.2d 808 (Texas 1992); Merritt v. Karcioglu, M.D. and Administrators of the Tulane Educational Fund, 668 S.2d 469 (La. 1996); Guilbeaux v. Lafayette General Hospital, 589 So.2d 629 (La. 1991); Butterfield v. Okubo, et al, 831 P.2d 97 (Utah 19920; Baptist Memorial Hospital System v. Sampson, 969 S.W.2d 945 (Texas 1998). NLM UID: 100889788.
KW - Health Facilities -- Legislation and Jurisprudence -- United States
KW - Liability, Legal
KW - Nurses -- Legislation and Jurisprudence -- United States
KW - Education, Continuing (Credit)
KW - United States
SP - 4p
EP - 4p
JO - Legal Medicine
JF - Legal Medicine
JA - LEGAL MED
CY - New York, New York
PB - Elsevier Science
AB - Historically, only physicians were sued for medical malpractice. They were seen as the 'captain of the ship' and held responsible for all aspects of a patient's care --even care delivered by others. Today, however, non-physician health care providers as well as their employing institutions and supervisors are increasingly being named as defendants in malpractice suits and held liable for their own actions. Effective risk management requires that every health care provider, health care administrator, and health care facility must recognize the various roles each fulfills and the many levels of liability that co-exist.
SN - 1344-6223
AD - IMA Consultant, United States Air Force Office of the Surgeon General, International Health Specialist Team, Bolling Air Force Base, Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Boucher, Philip E.
AU - Maris, Ann E.
AU - Yang, Mei-Shin
AU - Stibitz, Scott
T1 - The Response Regulator BvgA and RNA Polymerase α Subunit C-Terminal Domain Bind Simultaneously to Different Faces of the Same Segment of Promoter DNA
JO - Molecular Cell
JF - Molecular Cell
Y1 - 2003/01//
VL - 11
IS - 1
M3 - Article
SP - 163
SN - 10972765
AB - Examination of the binding of FeBABE-conjugated BvgA to the fha promoter of Bordetella pertussis has revealed that three dimers, formed by head-to-head association of monomers, bind one face of the DNA helix from the inverted-heptad primary binding site to the −35 region. The orientation of BvgA monomers within the dimers is the same as that recently demonstrated by X-ray crystallographic methods for a dimer of the C-terminal domain of NarL bound to DNA. Use of FeBABE conjugates of RNAP α subunit C-terminal domain showed that binding of this domain is linearly coincident with binding of the BvgA dimers, but to a different helical face. These results reveal a previously undescribed mode of interaction between RNAP α-CTD and a transcriptional activator. [Copyright &y& Elsevier]
AB - Copyright of Molecular Cell is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA pertussis
KW - DIMERS
N1 - Accession Number: 8996090; Boucher, Philip E. 1; Email Address: boucher@cber.fda.gov Maris, Ann E. 2 Yang, Mei-Shin 1 Stibitz, Scott 1; Affiliation: 1: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892 USA 2: Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 USA; Source Info: Jan2003, Vol. 11 Issue 1, p163; Subject Term: BORDETELLA pertussis; Subject Term: DIMERS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - Bucci, Thomas
AU - Heflich, Robert H.
AU - Desjardins, John
AU - Richardson, Frank C.
T1 - Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease
JO - Molecular Genetics & Metabolism
JF - Molecular Genetics & Metabolism
Y1 - 2003/01//
VL - 78
IS - 1
M3 - Article
SP - 1
SN - 10967192
AB - The thymidine kinase (Tk) gene codes for a cytosolic protein involved in the pyrimidine nucleotide salvage pathway. A functional Tk gene is not necessary for cells in culture, and a naturally occurring Tk deficient phenotype has not been described in humans or animal models. In order to determine the biological significance of the Tk gene, we created Tk−/− knockout (KO) mice through homologous recombination in mouse embryonic stem cells. Tk KO mice have shortened life spans compared with their wild-type or Tk heterozygous (HET) siblings. All Tk KO mice develop sclerosis of kidney glomeruli and die before one year of age of kidney failure. Among other changes in KO animals, the most consistent is a switch from exclusively mucous secretion to predominantly serous secretion in the sublingual salivary gland. HET parents can produce KO mice at a frequency approaching Mendelian inheritance. Other observations in KO animals include an elevated level of serum thymidine, a significant decrease in the cloning efficiency of splenic lymphocytes, an increase in the frequency of hypoxanthine guanine phosphoribosyl transferase gene mutant lymphocytes, and histological alteration in the lymphoid structure of the spleen. In addition, KO animals sporadically exhibit inflammation of the arteries, which taken together with the lymphocyte and spleen abnormalities, suggest an abnormal immune system. Alterations in Tk KO mice indicate that the pyrimidine nucleotide salvage pathway is indispensable in vivo. [Copyright &y& Elsevier]
AB - Copyright of Molecular Genetics & Metabolism is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYMIDINE
KW - KIDNEY glomerulus
KW - Kidney glomerulus
KW - Sublingual salivary gland
KW - Thymidine kinase
N1 - Accession Number: 9000005; Dobrovolsky, Vasily N. 1; Email Address: vdobrovolsky@nctr.fda.gov Bucci, Thomas 2 Heflich, Robert H. 1 Desjardins, John 3 Richardson, Frank C. 3; Affiliation: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA 2: Pathology Associates International, Jefferson, AR, USA 3: OSI Pharmaceuticals, Inc., Boulder, CO, USA; Source Info: Jan2003, Vol. 78 Issue 1, p1; Subject Term: THYMIDINE; Subject Term: KIDNEY glomerulus; Author-Supplied Keyword: Kidney glomerulus; Author-Supplied Keyword: Sublingual salivary gland; Author-Supplied Keyword: Thymidine kinase; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S1096-7192(02)00224-X
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Haihao
AU - Collins, Jerry M.
AU - Mangner, Thomas J.
AU - Muzik, Otto
AU - Shields, Anthony F.
T1 - Imaging [18F]FAU [1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl) uracil] in dogs
JO - Nuclear Medicine & Biology
JF - Nuclear Medicine & Biology
Y1 - 2003/01//
VL - 30
IS - 1
M3 - Article
SP - 25
SN - 09698051
AB - We have studied the biodistribution of [18F]FAU [(1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl)uracil], which previous work has shown is incorporated into DNA and functions as an inhibitor of DNA synthesis. It is being tested as a potential antineoplastic agent and imaging agent for PET. We have produced [18F]FAU and injected the tracer into 3 normal dogs and imaged them for up to 4 hours and removed tissues along with blood and urine samples for HPLC and activity analysis. The results showed that [18F]FAU evenly distributed to most of organs. In sharp contrast to our prior experience with thymidine and its analogs, marrow had less retention of [18F]FAU than the non-proliferating tissues. [Copyright &y& Elsevier]
AB - Copyright of Nuclear Medicine & Biology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URACIL
KW - ANTINEOPLASTIC agents
KW - EMISSION tomography
KW - THYMIDINE
KW - FAU
KW - PET
KW - Thymidine kinase
N1 - Accession Number: 8669205; Sun, Haihao 1 Collins, Jerry M. 2 Mangner, Thomas J. 1 Muzik, Otto 1 Shields, Anthony F. 1; Email Address: shieldsA@karmanos.org; Affiliation: 1: Karmanos Cancer Institute, Departments of Medicine and Radiology, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA 2: Food and Drug Administration, Bethesda, MD, USA; Source Info: Jan2003, Vol. 30 Issue 1, p25; Subject Term: URACIL; Subject Term: ANTINEOPLASTIC agents; Subject Term: EMISSION tomography; Subject Term: THYMIDINE; Author-Supplied Keyword: FAU; Author-Supplied Keyword: PET; Author-Supplied Keyword: Thymidine kinase; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106860615
T1 - Visual and ocular changes associated with exposure to two tertiary amines.
AU - Page EH
AU - Cook CK
AU - Hater MA
AU - Mueller CA
AU - Grote AA
AU - Mortimer VD
Y1 - 2003/01//
N1 - Accession Number: 106860615. Language: English. Entry Date: 20030822. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Amines -- Adverse Effects
KW - Cornea -- Pathology
KW - Occupational Diseases
KW - Occupational Exposure -- Adverse Effects
KW - Vision Disorders -- Chemically Induced
KW - Vision -- Drug Effects
KW - Air -- Analysis
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Diagnosis, Eye
KW - Dyes -- Adverse Effects
KW - Environmental Monitoring
KW - Epidemiological Research
KW - Graphics
KW - Logistic Regression
KW - National Institute for Occupational Safety and Health -- Standards
KW - Odds Ratio
KW - Prevalence
KW - Questionnaires
KW - Statistical Significance
KW - United States
KW - Ventilation
KW - Human
SP - 69
EP - 75
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 60
IS - 1
PB - BMJ Publishing Group
AB - AIMS: To determine if exposure to dimethylisopropanolamine (DMIPA) and dimethylaminoethanol (DMAE) in a label printing plant was associated with visual disturbances and/or ocular changes. METHODS: Questionnaires, eye examinations (visual acuity, contrast sensitivity at 2.5% and 1.25% contrast, slit lamp biomicroscopy, and pachymetry), and industrial hygiene monitoring for DMIPA and DMAE were performed over a two week period. RESULTS: Eighty nine per cent of line workers reported having experienced blurry vision while at work in the past 12 months, compared to 12.5% of prime workers. A total of 108 full shift personal breathing zone (PBZ) air samples for the amines were collected. The mean time weighted average (TWA) concentration of DMIPA was significantly higher in the line division than in the prime division, as was the mean TWA concentration for total amines. The mean TWA concentration of DMAE was higher in the prime division than the line division. Higher levels of total amines were associated with increased risk of reporting blurry vision, halo vision, and blue-grey vision. The risk of corneal opacity rose with increasing exposure to total amines. The prevalence of corneal opacity also increased with increasing concentration of total amines. Median corneal thickness increased with increasing grades of corneal opacity. There was a statistically significant relation between total amine concentration and increased risk of reduced bilateral visual acuity and 2.5% contrast sensitivity. CONCLUSIONS: Exposure to tertiary amines was associated with blurry, halo, and blue-grey vision, corneal opacity, and decrements in visual acuity and contrast sensitivity at 2.5% contrast.
SN - 1351-0711
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-10, Cincinnati, OH 45226-1998
U2 - PMID: 12499461.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106860615&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2003-04375-006
AN - 2003-04375-006
AU - Hill, Gil
AU - Howard, Alison
AU - Weaver, Donald L.
AU - Stamm, B. Hudnall
ED - Stamm, B. Hudnall
ED - Stamm, B. Hudnall, (Ed)
T1 - Health planning for rural and frontier mental and behavioral health care.
T2 - Rural behavioral health care: An interdisciplinary guide.
Y1 - 2003///
SP - 81
EP - 91
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-55798-983-4
AD - Hill, Gil, 1910 S Street, NW, Washington, DC, US, 20009
N1 - Accession Number: 2003-04375-006. Partial author list: First Author & Affiliation: Hill, Gil; American Psychological Association, Practice Directorate, Offices of Rural Health & Substance Abuse, Washington, DC, US. Release Date: 20030310. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55798-983-4, Paperback. Language: English. Major Descriptor: Funding; Health Care Delivery; Health Care Psychology; Mental Health Services; Rural Environments. Minor Descriptor: Health Service Needs. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 11.
AB - In this chapter, the authors present information for health planning and funding for rural and frontier mental and behavioral health care in the US. The first section encompasses identifying and selecting target areas and robust models for designing service delivery systems that incorporate the formal and informal health resources and allow for the incorporation of new health needs or resources. The second portion of the chapter provides information about locating and securing funds for building and sustaining health systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service delivery systems
KW - behavioral health care
KW - health resources
KW - health planning
KW - funding
KW - health needs
KW - rural & frontier areas
KW - 2003
KW - Funding
KW - Health Care Delivery
KW - Health Care Psychology
KW - Mental Health Services
KW - Rural Environments
KW - Health Service Needs
KW - 2003
DO - 10.1037/10489-006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-04375-006&site=ehost-live&scope=site
UR - DWeaver@HRSA.GOV
UR - gilhill1910@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
AU - Hill, Steven C.
AU - Livermore, Gina A.
AU - Houtenville, Andrew J.
AD - Agency for Healthcare Research and Quality
AD - Cornell U
AD - Cornell U
A2 - Stapleton, David C.
A2 - Burkhauser, Richard V.
T1 - Rising Health Care Expenditures and the Employment of People with High-Cost Chronic Conditions
T2 - The decline in employment of people with disabilities: A policy puzzle
PB - Kalamazoo, Mich.:
PB - W. E. Upjohn Institute for Employment Research
Y1 - 2003///
SP - 181
EP - 215
N1 - Accession Number: 0790857; Reviewed Book ISBN: 0-88099-260-3; 0-88099-259-X; Keywords: Health Care; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200509
KW - Analysis of Health Care Markets I11
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
KW - Safety; Job Satisfaction; Related Public Policy J28
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0790857&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Kotewicz, Michael L.
AU - Brown, Eric W.
AU - Eugene LeClerc, J.
AU - Cebula, Thomas A.
T1 - Genomic variability among enteric pathogens: the case of the mutS–rpoS intergenic region
JO - Trends in Microbiology
JF - Trends in Microbiology
Y1 - 2003/01//
VL - 11
IS - 1
M3 - Article
SP - 2
SN - 0966842X
AB - The mutS–rpoS intergenic region of enteric bacteria ranges in size from 88 bp in Yersinia to >12 000 bp in Salmonella. We interpret this expansion as the result of the horizontal transfer of segments of DNA from diverse origins. Both comparative genomic analysis and selective sequencing of a variety of Escherichia coli pathogens have provided additional evidence for reassortment of segments within this region. [Copyright &y& Elsevier]
AB - Copyright of Trends in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - INTESTINES -- Infections
KW - ESCHERICHIA coli
N1 - Accession Number: 8901702; Kotewicz, Michael L. 1 Brown, Eric W. 1 Eugene LeClerc, J. 1 Cebula, Thomas A. 1; Email Address: tcebula@cfsan.fda.gov; Affiliation: 1: Division of Molecular Biology, Center for Food Safety & Applied Nutrition, US Food and Drug Administration, MOD-1, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jan2003, Vol. 11 Issue 1, p2; Subject Term: PATHOGENIC microorganisms; Subject Term: INTESTINES -- Infections; Subject Term: ESCHERICHIA coli; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8901702&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2003-88209-003
AN - 2003-88209-003
AU - Murphy, Lawrence R.
AU - Pepper, Lewis D.
ED - Peterson, Chris L.
ED - Peterson, Chris L., (Ed)
T1 - Effects of organizational downsizing on worker stress and health in the United States.
T2 - Work stress: Studies of the context, content and outcomes of stress: A book of readings.
T3 - Policy, politics, health and medicine series
Y1 - 2003///
SP - 53
EP - 71
CY - Amityville, NY, US
PB - Baywood Publishing Co
SN - 0-89503-280-5
N1 - Accession Number: 2003-88209-003. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; U.S. National Institute for Occupational Safety and Health, US. Release Date: 20041129. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-89503-280-5, Hardcover. Language: English. Major Descriptor: Coping Behavior; Downsizing; Health; Job Security; Occupational Stress. Minor Descriptor: Syndromes; Working Conditions. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19.
AB - This chapter examines the effects of downsizing on worker stress, coping, survivor syndrome health, and job security in two sites that represent extremes of downsizing. One site (site B) had been engaged in repeated episodes of downsizing since 1992; the other site (site A) had a single downsizing episode the year before the data were collected. The two sites also differed in the type of layoffs that occurred. In site A, all the layoffs were voluntary (e.g.; early retirement), while at site B, about half of the workers lost their jobs through involuntary layoffs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - downsizing
KW - worker stress
KW - coping
KW - survivor syndrome health
KW - job security
KW - 2003
KW - Coping Behavior
KW - Downsizing
KW - Health
KW - Job Security
KW - Occupational Stress
KW - Syndromes
KW - Working Conditions
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-88209-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-04250-001
AN - 2003-04250-001
AU - Coben, Jeffrey H.
AU - Steiner, Claudia A.
T1 - Hospitalization for Firearm-Related Injuries in the United States, 1997.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2003/01//
VL - 24
IS - 1
SP - 1
EP - 8
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Coben, Jeffrey H., Center for Violence and Injury Control, 320 E. North Avenue, Snyder Pavilion, Suite 214, Pittsburgh, PA, US, 15212
N1 - Accession Number: 2003-04250-001. PMID: 12554017 Partial author list: First Author & Affiliation: Coben, Jeffrey H.; Center for Outcomes and Effectiveness, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, MD, US. Release Date: 20031201. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Firearms; Hospitalization; Injuries; Public Health. Minor Descriptor: Epidemiology. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2003.
AB - Firearm-related injuries are a serious public health problem in the United States. Despite the magnitude of this problem, prior national estimates of nonfatal, firearm-related morbidity have been limited to an emergency department-based surveillance system. The objective of this study was to assess and report the information available on firearm-related injuries in an existing national database, derived from hospital discharge data. Cross-sectional analysis was applied to the 1997 Nationwide Inpatient Sample, a stratified probability sample of 1,012 nonfederal community hospitals from 22 states. The SUDAAN software program was used to convert raw counts into weighted counts that represent national estimates and 95% confidence intervals. An estimated 35,810 cases nationwide were identified, of which 86% were male. Assault was the leading cause of firearm-related hospitalization, followed by unintentional injury. The total estimated hospital charges for firearm-related injuries in the United States in 1997 was over $802 million, and 29% of the patients admitted for this condition were uninsured. National estimates derived from the NIS are consistent with previous estimates, and NIS provides additional information not available from other data sources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospitalization
KW - firearm related injuries
KW - United States
KW - public health problem
KW - firearm related morbidity
KW - emergency department based surveillance system
KW - 2003
KW - Firearms
KW - Hospitalization
KW - Injuries
KW - Public Health
KW - Epidemiology
KW - 2003
DO - 10.1016/S0749-3797(02)00578-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-04250-001&site=ehost-live&scope=site
UR - jcoben@wpahs.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20453-001
AN - 2004-20453-001
AU - Haaz, Edward J.
AU - Maynard, John
AU - Petrica, Stephen C.
AU - Williams, Charles E.
T1 - Employee assistance program accreditation: History and outlook.
JF - Employee Assistance Quarterly
JO - Employee Assistance Quarterly
Y1 - 2003///
VL - 19
IS - 1
SP - 1
EP - 26
CY - US
PB - Haworth Press
SN - 0749-0003
AD - Haaz, Edward J., CSAP/SAMHSA, Rockwall II Building Room 920, 5515 Security Lane, Rockville, MD, US, 20852
N1 - Accession Number: 2004-20453-001. Other Journal Title: Journal of Workplace Behavioral Health. Partial author list: First Author & Affiliation: Haaz, Edward J.; Mental Health Consultants, Inc., Furlong, PA, US. Other Publishers: Taylor & Francis. Release Date: 20041206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Program Evaluation. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Location: Canada; US. References Available: Y. Page Count: 26. Issue Publication Date: 2003.
AB - Accreditation is a means of verifying the professional competence and programmatic integrity of an employee assistance program (EAP). This paper examines the history of the accreditation of EAPs in the United States and Canada by the two dominant professional associations in the field, and makes some observations about the outlook for EAP accreditation. The two professional associations, driven by divergent philosophies, have evolved differently in their approach to accreditation. However, they share the conviction that control of standards is essential to the self-definition of a professional field, and has implications as well for marketing and governmental regulation. Accreditation thus has an important role in those areas, and should define acceptable standards in the emerging employee assistance environment, which entails such issues as managed behavioral health care, work-life, and international programs. Accreditation may also help advance thinking about current tensions in the field, and thus help shape its future. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employee assistance program
KW - accreditation
KW - 2003
KW - Employee Assistance Programs
KW - Program Evaluation
KW - 2003
DO - 10.1300/J022v19n01_01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20453-001&site=ehost-live&scope=site
UR - cwilliam@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-01560-003
AN - 2005-01560-003
AU - Stephenson, Diane
AU - Bingaman, David
AU - Plaza, Chris
AU - Selvik, Rick
AU - Sudgen, Brian
AU - Ross, Christopher
T1 - Implementation and Evaluation of a Formal Telephone Counseling Protocol in an Employee Assistance Program.
JF - Employee Assistance Quarterly
JO - Employee Assistance Quarterly
Y1 - 2003///
VL - 19
IS - 2
SP - 19
EP - 33
CY - US
PB - Haworth Press
SN - 0749-0003
AD - Stephenson, Diane, Federal Occupational Health Program Support Center, Department of Health and Human Services, 233 N. Michigan Avenue, Suite 270, Chicago, IL, US, 60601
N1 - Accession Number: 2005-01560-003. Other Journal Title: Journal of Workplace Behavioral Health. Partial author list: First Author & Affiliation: Stephenson, Diane; Federal Occupational Health Program Support Center, Department of Health and Human Services, Chicago, IL, US. Other Publishers: Taylor & Francis. Release Date: 20050321. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Employee Assistance Programs; Telemedicine. Minor Descriptor: Client Satisfaction; Employee Absenteeism; Employee Productivity; Health Care Utilization; Treatment Outcomes. Classification: Personnel Management & Selection & Training (3620); Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Counseling Clinical Outcome-Global Assessment of Functioning; Client Satisfaction Ratings on Quality of Service Received; Client Satisfaction Ratings on Access to Care and Outcomes. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 15. Issue Publication Date: 2003.
AB - Structured guidelines for conducting telephone counseling were developed and implemented in a large employee assistance program. This study evaluated the telephone counseling service in several areas, including utilization, clinical outcomes, client satisfaction, client reported productivity and absenteeism, counselor feedback, and efficiency. Clients who elected the telephone counseling modality and who were determined by the counselor to be appropriate for telephone counseling showed results comparable to those for face-to-face counseling on various measures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employee assistance program
KW - telephone counseling service
KW - service utilization
KW - clinical outcome
KW - client satisfaction
KW - employee productivity
KW - absenteeism
KW - counselor feedback
KW - 2003
KW - Counseling
KW - Employee Assistance Programs
KW - Telemedicine
KW - Client Satisfaction
KW - Employee Absenteeism
KW - Employee Productivity
KW - Health Care Utilization
KW - Treatment Outcomes
KW - 2003
DO - 10.1300/J022v19n02_02
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01560-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11490-003
AN - 2004-11490-003
AU - Hafkenscheid, Anton
T1 - Objective countertransference: Do patients' interpersonal impacts generalize across therapists?
JF - Clinical Psychology & Psychotherapy
JO - Clinical Psychology & Psychotherapy
JA - Clin Psychol Psychother
Y1 - 2003/01//Jan-Feb, 2003
VL - 10
IS - 1
SP - 31
EP - 40
CY - US
PB - John Wiley & Sons
SN - 1063-3995
SN - 1099-0879
AD - Hafkenscheid, Anton, Sinai Center, Jewish Mental Health Services, PO Box 66, 3800 AB, Amersfoort, Netherlands
N1 - Accession Number: 2004-11490-003. Partial author list: First Author & Affiliation: Hafkenscheid, Anton; Sinai Center, Jewish Mental Health Services, Amersfoort, Netherlands. Release Date: 20040329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Countertransference; Interpersonal Interaction; Interpersonal Psychotherapy; Psychotherapeutic Processes; Therapists. Classification: Interpersonal & Client Centered & Humanistic Therapy (3314). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Impact Message Inventory DOI: 10.1037/t02262-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan-Feb, 2003.
AB - Objective countertransference refers to the constricted feelings, attitudes and reactions of a therapist, that are induced primarily by the patient's maladaptive behaviour and that are generalizable to other therapists (and to other significant others in the patient's life). In interpersonal theory and therapy, the equivalent of objective countertransference is the impact message concept. Impact messages refer to the cognitions, emotions and action tendencies evoked in the therapist by a particular patient's interpersonal pressures. This paper tests the interpersonal hypothesis that interpersonal impact generalizes across therapists (and by extension across interpersonal relationships). Generalizability of impact messages across therapists was determined for different combinations of therapist pairs, independently rating a total of 131 psychiatric outpatients with the IMI-C (Impact Message Inventory, revised circumplex version). It was found that impact messages were most clearly generalizable across therapists for the Dominance (D) category, followed by the Hostile-Dominant (HD) and Hostile-Submissive (HS) categories. In contrast, the other five categories of impact messages turned out to be poorly generalizable across therapists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - objective countertransference
KW - interpersonal theory
KW - interpersonal therapy
KW - impact messages
KW - interpersonal impacts
KW - therapists
KW - 2003
KW - Countertransference
KW - Interpersonal Interaction
KW - Interpersonal Psychotherapy
KW - Psychotherapeutic Processes
KW - Therapists
KW - 2003
DO - 10.1002/cpp.349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11490-003&site=ehost-live&scope=site
UR - hafkenscheid@sinai.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-03799-007
AN - 2003-03799-007
AU - Gossage, J. Phillip
AU - Barton, Louie
AU - Foster, Lenny
AU - Etsitty, Larry
AU - LoneTree, Clayton
AU - Leonard, Carol
AU - May, Philip A.
T1 - Sweat lodge ceremonies for jail-based treatment.
JF - Journal of Psychoactive Drugs
JO - Journal of Psychoactive Drugs
JA - J Psychoactive Drugs
Y1 - 2003/01//Jan-Mar, 2003
VL - 35
IS - 1
SP - 33
EP - 42
CY - US
PB - Haight-Ashbury Publications
SN - 0279-1072
SN - 2159-9777
AD - Gossage, J. Phillip, The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, 2650 Yale Boulevard SE, Suite 100, Albuquerque, NM, US, 87106-3202.
N1 - Accession Number: 2003-03799-007. PMID: 12733756 Other Journal Title: Journal of Psychedelic Drugs. Partial author list: First Author & Affiliation: Gossage, J. Phillip; The University of New Mexico, Center on Alcoholism, Substance Abuse & Addictions, Albuquerque, NM, US. Other Publishers: Taylor & Francis. Release Date: 20031208. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Rehabilitation; American Indians; Culture (Anthropological); Drug Rehabilitation; Prisoners. Minor Descriptor: Patients. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan-Mar, 2003.
AB - Sweat lodge ceremonies (SLCs) have been an integral part of Navajo culture for hundreds of years. The Dine' Center for Substance Abuse Treatment staff utilized SLCs as a modality for jail-based treatment. Data were collected from the Spring of 1996 through the Spring of 1999 from 190 men ranging in age from 18 to 64. These inmate/patients (IPs) provided information at intake on a broad range of questions which were important in understanding the problems these men were having with alcohol and other drugs. Experiential data were collected from 123 IPs after each SLC. Several cultural variables showed improvement in the IP's world view following the SLCs. Even though there were few areas where data were statistically significant, several drinking measures changed in a positive direction. For example, among those subjects who were followed-up, analysis revealed a decrease in the number of drinks consumed in drinking sessions from a mean of 6.7 drinks at intake to a mean of 5.3 drinks. This article examines the role of SLCs in traditional counseling in jail-based treatment of alcohol abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - traditional counseling
KW - alcohol abuse
KW - Navajo culture
KW - sweat lodge ceremonies
KW - SLC
KW - jail-based treatment
KW - inmate patients
KW - 2003
KW - Alcohol Rehabilitation
KW - American Indians
KW - Culture (Anthropological)
KW - Drug Rehabilitation
KW - Prisoners
KW - Patients
KW - 2003
DO - 10.1080/02791072.2003.10399991
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-03799-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-04923-006
AN - 2003-04923-006
AU - Horton, Arthur MacNeill
AU - Roberts, Charles
T1 - Demographic effects on the Trail Making Test in a drug abuse treatment sample.
JF - Archives of Clinical Neuropsychology
JO - Archives of Clinical Neuropsychology
JA - Arch Clin Neuropsychol
Y1 - 2003/01//
VL - 18
IS - 1
SP - 49
EP - 56
CY - Netherlands
PB - Elsevier Science
SN - 0887-6177
SN - 1873-5843
AD - Horton, Arthur MacNeill
N1 - Accession Number: 2003-04923-006. PMID: 14591477 Partial author list: First Author & Affiliation: Horton, Arthur MacNeill; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20030310. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Neuropsychological Assessment. Minor Descriptor: Screening. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2003.
AB - Suggests that appreciation of the importance of screening for cognitive impairment among substance abusing populations has increased in recent years. In this article, demographic effects on the Trail Making Test (TMT), a test often used for screening for cognitive impairment, are examined in a sample of patients in drug abuse treatment programs. A sample of 5,619 males and 2,902 females was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). The DATOS was a naturalistic cohort study that collected data from 1991 to 1993 in 96 programs in 11 cities in the US. Data were analyzed to determine the effects of demographic variables on the 2 parts of the TMT in this large sample of patients. Consistent with previous research, demographic variables such as age, gender, education level, and ethnicity were statistically significantly related to both TMT Parts A and B. More importantly, however, the percentage of variance accounted for was quite small. These results suggest that, while clearly present, demographic effects on the TMT are weak. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - demographic variables
KW - cognitive impairment
KW - Trail Making Test
KW - drug abuse treatment clients
KW - 2003
KW - Cognitive Ability
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Neuropsychological Assessment
KW - Screening
KW - 2003
DO - 10.1016/S0887-6177(01)00183-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-04923-006&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-02735-008
AN - 2003-02735-008
AU - Mulvey, Kevin P.
AU - Hubbard, Susan
AU - Hayashi, Susan
T1 - A national study of the substance abuse treatment workforce.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2003/01//
VL - 24
IS - 1
SP - 51
EP - 57
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Mulvey, Kevin P.
N1 - Accession Number: 2003-02735-008. PMID: 12646330 Partial author list: First Author & Affiliation: Mulvey, Kevin P.; Ctr for Substance Abuse Treatment, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Release Date: 20030414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Drug Rehabilitation; Health Personnel. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Retrospective Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2003.
AB - This study's purpose is to gain a current perspective on the substance abuse treatment field's workforce. The data are from the Retrospective Study of treatment professionals designed to document how the Treatment Improvement Protocols published by the Center for Substance Abuse Treatment have influenced the implementation of best practices. The Retrospective Study consisted of a 2-wave cross-sectional survey with telephone follow-up. Data for this study were from demographic information on Wave 1 study participants, which had a response rate of 80.1% (N = 3,267). The results of the study showed that most treatment professionals are White (84.5%) and middle-aged (i.e., between 40 and 55 years old) and slightly more are female (50.5.0%) than male (49.5%). Treatment professionals tend to enter the field and stay in it, and almost 80.0% of respondents possess a bachelor's degree or higher. In addition, most treatment professionals are licensed or certified and treat clients from different racial and ethnic backgrounds than themselves. Implications for the provision of treatment services are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - workforce
KW - treatment professionals
KW - demographics
KW - 2003
KW - Demographic Characteristics
KW - Drug Rehabilitation
KW - Health Personnel
KW - 2003
DO - 10.1016/S0740-5472(02)00322-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-02735-008&site=ehost-live&scope=site
UR - kmulvey@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-04643-007
AN - 2003-04643-007
AU - Sang, Christine N.
AU - Max, Mitchell B.
AU - Gracely, Richard H.
T1 - Stability and Reliability of Detection Thresholds for Human A-Beta and A-Delta Sensory Afferents Determined by Cutaneous Electrical Stimulation.
JF - Journal of Pain and Symptom Management
JO - Journal of Pain and Symptom Management
JA - J Pain Symptom Manage
Y1 - 2003/01//
VL - 25
IS - 1
SP - 64
EP - 73
CY - Netherlands
PB - Elsevier Science
SN - 0885-3924
AD - Sang, Christine N., Department of Anesthesia, Clinics 3, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, US, 02114
N1 - Accession Number: 2003-04643-007. PMID: 12565190 Partial author list: First Author & Affiliation: Sang, Christine N.; Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US. Release Date: 20031215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neurons; Pain. Minor Descriptor: Pain Thresholds; Tactual Perception. Classification: Electrophysiology (2530). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jan, 2003.
AB - Activity in primary afferent fibers that usually mediate fine touch can evoke sensations of pain in conditions in which there is sensitization of central neurons. The role of these fibers in clinical pain syndromes can be evaluated by applications of electrical stimuli that preferentially activate Aβ axons. This study assessed the stability and reliability of a method of electrical stimulation (ES) useful for clinical evaluation. Monopolar constant-current rectangular pulses were delivered to 5 equi-spaced sites on the volar aspect of the left forearm along a transverse line 5 cm distal to the antecubital crease. Current intensity was gradually increased to determine detection threshold and pain detection threshold. This study determined: 1) Effect of pulse duration (1, 2, and 5 msec); 2) the variation of detection threshold and pain threshold over repeated stimulation; 3) the effect of electrode position with respect to distance from the trunk of underlying ulnar or median nerves; and 4) the effect of repositioning the electrode on variability of detection threshold and pain threshold. Our results suggest that in skin unaffected by allodynia, a ratio of the two sensory thresholds (pain threshold and detection threshold) of less than 2.0 is uncommon. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - detection threshold
KW - sensory afferent fibers
KW - pain sensations
KW - central neurons sensitization
KW - clinical pain syndromes
KW - touch
KW - allodynia
KW - 2003
KW - Neurons
KW - Pain
KW - Pain Thresholds
KW - Tactual Perception
KW - 2003
DO - 10.1016/S0885-3924(02)00541-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-04643-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05432-006
AN - 2003-05432-006
AU - Sale, Elizabeth
AU - Sambrano, Soledad
AU - Springer, J. Fred
AU - Turner, Charles W.
T1 - Risk, protection, and substance use in adolescents: A multi-site model.
JF - Journal of Drug Education
JO - Journal of Drug Education
JA - J Drug Educ
Y1 - 2003///
VL - 33
IS - 1
SP - 91
EP - 105
CY - US
PB - Baywood Publishing
SN - 0047-2379
SN - 1541-4159
AD - Sale, Elizabeth, EMT Associates, Inc, 2nd Floor, 208 North Euclid, St. Louis, MO, US, 63108-1602
N1 - Accession Number: 2003-05432-006. PMID: 12773027 Partial author list: First Author & Affiliation: Sale, Elizabeth; EMT Associates, Inc, St Louis, US. Other Publishers: Sage Publications. Release Date: 20030616. Correction Date: 20150126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Drug Abuse Prevention; Drug Usage; Protective Factors; Risk Factors. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 15. Issue Publication Date: 2003.
AB - This article reports findings from a national longitudinal cross-site evaluation of high-risk youth to clarify the relationships between risk and protective factors and substance use. Using structural equation modeling, baseline data on 10,473 youth between the ages of 9 and 18 in 48 high-risk communities around the nation are analyzed. Youth were assessed on substance use (cigarette, alcohol, and marijuana use), external risk factors including family, school, peer and neighborhood influences, and individual risk and protective factors including self-control, family connectedness, and school connectedness. Findings indicate strong direct relationships between peer and parental substance use norms and substance use. Individual protective factors, particularly family and school connectedness were strong mediators of individual substance use. These findings suggest that multi-dimensional prevention programming stressing the fostering of conventional anti-substance use attitudes among parents and peers, the importance of parental supervision, and development of strong connections between youth and their family, peers, and school may be most effective in preventing and reducing substance use patterns among high-risk youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk factors
KW - protective factors
KW - high-risk youth
KW - substance use
KW - 2003
KW - At Risk Populations
KW - Drug Abuse Prevention
KW - Drug Usage
KW - Protective Factors
KW - Risk Factors
KW - 2003
DO - 10.2190/LFJ0-ER64-1FVY-PA7L
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05432-006&site=ehost-live&scope=site
UR - esale@emt.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11083-015
AN - 2004-11083-015
AU - Zarem, Sara
T1 - Signs of connection working with deaf parents and hearing children in a nursery setting.
JF - The Psychoanalytic Study of the Child
JO - The Psychoanalytic Study of the Child
JA - Psychoanal Study Child
Y1 - 2003///
VL - 58
SP - 228
EP - 245
CY - US
PB - Yale University Press
SN - 0079-7308
N1 - Accession Number: 2004-11083-015. PMID: 14982023 Partial author list: First Author & Affiliation: Zarem, Sara; Lexington Center for Mental Health Services, Inc., NY, US. Release Date: 20040405. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Deaf; Emotional Development; Parent Child Relations; Psychoanalysis; Psychosocial Development. Minor Descriptor: Nursery Schools; Parents; Prevention; Sign Language. Classification: Childrearing & Child Care (2956); Psychoanalytic Therapy (3315). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 18. Issue Publication Date: 2003.
AB - When deaf adults find themselves the parents of a hearing child, a cycle of disrupted communication and attachment may ensue between the parent and child. Not only may the parent-child bond be compromised, but the social-emotional development of the child and the parents 'feelings of empowerment may be at risk as well. This paper details a psychoanalytically-informed approach to working with mixed deaf and hearing parent-child relationships in a nursery setting where the goal is to prevent such potential disruptions and derailments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social emotional development
KW - parent child relationships
KW - nursery setting
KW - hearing child
KW - deaf parents
KW - deaf adults
KW - sign language
KW - preventive approach
KW - 2003
KW - Deaf
KW - Emotional Development
KW - Parent Child Relations
KW - Psychoanalysis
KW - Psychosocial Development
KW - Nursery Schools
KW - Parents
KW - Prevention
KW - Sign Language
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11083-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-08727-008
AN - 2003-08727-008
AU - Bilbao, Alvaro
AU - Kennedy, Cille
AU - Chatterji, Somnath
AU - Üstün, Bedirhan
AU - Barquero, José Luis Vásquez
AU - Barth, Jeffrey T.
T1 - The ICF: Applications of the WHO model of functioning, disability and health to brain injury rehabilitation.
JF - NeuroRehabilitation
JO - NeuroRehabilitation
JA - NeuroRehabilitation
Y1 - 2003///
VL - 18
IS - 3
SP - 239
EP - 250
CY - Netherlands
PB - IOS Press
SN - 1053-8135
SN - 1878-6448
AD - Kennedy, Cille, DHHS/DALTCP, Room 424E, 200 Independence Avenue, SW, Washington, DC, US, 20201
N1 - Accession Number: 2003-08727-008. PMID: 14530589 Partial author list: First Author & Affiliation: Bilbao, Alvaro; Neuropsicólogo, Centro Estatal de Atención al Daão Cerebral, Madrid, Spain. Release Date: 20031027. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Models; Psychodiagnostic Typologies; Taxonomies; Traumatic Brain Injury. Minor Descriptor: Rehabilitation. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: 2003.
AB - The traditional disease and diagnostic medical model is not always useful to brain injury professionals who need to describe, measure, and compare deficits associated with neurologic insult. Professionals in neurorehabilitation are in need of new systems that will assist them in identifying impairments and areas of intervention. The aim of this article is to present the International Classification of Functioning, Disability and Health (ICF), and its applications to brain injury rehabilitation. This taxonomy, developed by the WHO, allows the classification and assessment of functioning and disability in everyday activities and social involvement for individuals with medical conditions. Multi-disciplinary teams from 65 countries have collaborated in the development of the ICF to develop a tool that serves different purposes and disciplines with high trans-cultural validity. It can be of great value for professionals working in the field of brain injury who need to describe and quantify in detail neurocognitive, emotional, and sensory-motor functions as well as their impact on activities and participation in life situations. Its applications also extend to the domains of epidemiology, public health and public policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - International Classification of Functioning Disability & Health
KW - ICF
KW - diagnostic taxonomies
KW - brain injury rehabilitation
KW - World Health Organization
KW - model development
KW - 2003
KW - Health
KW - Models
KW - Psychodiagnostic Typologies
KW - Taxonomies
KW - Traumatic Brain Injury
KW - Rehabilitation
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-08727-008&site=ehost-live&scope=site
UR - cille.kennedy@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-08619-006
AN - 2003-08619-006
AU - Lehman, Anthony F.
AU - Fischer, Ellen P.
AU - Postrado, Leticia
AU - Delahanty, Janine
AU - Johnstone, Bryan M.
AU - Russo, Patricia A.
AU - Crown, William H.
T1 - The Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ): An instrument to assess outcomes of schizophrenia care.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 2003///
VL - 29
IS - 2
SP - 247
EP - 256
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Lehman, Anthony F., University of Maryland, Department of Psychiatry, 701 West Pratt St., Baltimore, MD, US, 21201
N1 - Accession Number: 2003-08619-006. PMID: 14552500 Partial author list: First Author & Affiliation: Lehman, Anthony F.; Center for Mental Health Services Research, University of Maryland, Baltimore, Baltimore, MD, US. Other Publishers: Oxford University Press. Release Date: 20031027. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Questionnaires; Schizoaffective Disorder; Schizophrenia; Test Construction; Treatment Outcomes. Minor Descriptor: Health; Health Care Services; Psychiatric Symptoms; Psychometrics; Quality of Care; Quality of Life; Safety; Test Reliability; Test Validity. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Positive and Negative Syndrome Scale DOI: 10.1037/t05056-000; Lehman Quality of Life Interview; Montgomery-Asberg Depression Rating Scale DOI: 10.1037/t04111-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2003.
AB - Advances in treatment technologies and development of evidence-based standards of care demand better methods for routine assessment of outcomes for schizophrenia in systems of care. This article describes the development and psychometrics of a new instrument to assess outcomes of routine care for persons with schizophrenia in service systems. Candidate items for the Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ) were drawn from existing measures. Domains covered include disease outcomes (symptoms, subjective medication effects, substance abuse), functional status, health status, quality of life, and public safety. A sample of 1,584 patients with schizophrenia or schizoaffective disorder who were recruited into a large prospective, naturalistic study on the course of treatment for schizophrenia completed the SCAP-HQ at baseline and 1 year later (n=434), providing data for factor analysis, assessment of internal consistency, convergent validity, and responsiveness to change. A subsample of 121 patients completed a test-retest protocol. Fifteen scales were derived by factor analysis from 55 outcome items on the SCAP-HQ. These factors covered psychiatric symptoms, life satisfaction, instrumental activities of daily living, health-related mental disability... (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - routine care quality
KW - schizoaffective disorder
KW - schizophrenia
KW - outcome measures
KW - assessment scales
KW - systems care
KW - psychometrics
KW - Schizophrenia Care and Assessment Program Health Questionnaireaire
KW - 2003
KW - Questionnaires
KW - Schizoaffective Disorder
KW - Schizophrenia
KW - Test Construction
KW - Treatment Outcomes
KW - Health
KW - Health Care Services
KW - Psychiatric Symptoms
KW - Psychometrics
KW - Quality of Care
KW - Quality of Life
KW - Safety
KW - Test Reliability
KW - Test Validity
KW - 2003
DO - 10.1093/oxfordjournals.schbul.a007001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-08619-006&site=ehost-live&scope=site
UR - alehman@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10783-005
AN - 2004-10783-005
AU - Kowalski-Trakofler, Kathleen M.
AU - Barrett, Edward A.
T1 - The concept of degraded images applied to hazard recognition training in mining for reduction of lost-time injuries.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2003///
VL - 34
IS - 5
SP - 515
EP - 525
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Kowalski-Trakofler, Kathleen M., National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA, US, 15236
N1 - Accession Number: 2004-10783-005. PMID: 14733985 Partial author list: First Author & Affiliation: Kowalski-Trakofler, Kathleen M.; National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, Pittsburgh, PA, US. Release Date: 20040906. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual Institute on Mining Health, Safety, and Research, 25th, 1995, Blacksburg, VA, US. Conference Note: Portions of this research were presented at the aforementioned conference and IC 9422, Information Circular, U.S. Department of Interior, 1995; and The 23rd International Congress of Applied Psychology Madrid, Spain 1994. Major Descriptor: Hazards; Industrial Accidents; Occupational Safety; Personnel Training; Working Conditions. Minor Descriptor: Injuries. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Literature Review. References Available: Y. Page Count: 11. Issue Publication Date: 2003.
AB - This paper discusses the application of a training intervention that uses degraded images for improving the hazard recognition skills of miners. NIOSH researchers, in an extensive literature review, identified fundamental psychological principles on perception that may be employed to enhance the ability of miners to recognize and respond to hazards in their dangerous work environment. Three studies were conducted to evaluate the effectiveness of the degraded image training intervention. A model of hazard recognition was developed to guide the study. In the first study, miners from Pennsylvania, West Virginia and Alabama, who were taught with the aid of degraded images, scored significantly better on follow-up hazard recognition performance measures than those trained using traditional instructional methodologies. The second and third studies investigated the effectiveness of the training intervention at two mining companies. Data collected over a 3-year period showed that lost-time injuries at mines in Alabama and Illinois declined soon after the training intervention was instituted. Further exploration of the hazard recognition model and the development of other interventions based on the model could support the validity of the steps in the hazard recognition model. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - degraded images
KW - hazard recognition training
KW - mining
KW - lost-time injury
KW - injury reduction
KW - training intervention
KW - miners
KW - 2003
KW - Hazards
KW - Industrial Accidents
KW - Occupational Safety
KW - Personnel Training
KW - Working Conditions
KW - Injuries
KW - 2003
DO - 10.1016/j.jsr.2003.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10783-005&site=ehost-live&scope=site
UR - kkowalski@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10783-009
AN - 2004-10783-009
AU - Sinclair, Raymond C.
AU - Smith, Randall
AU - Colligan, Michael
AU - Prince, Mary
AU - Nguyen, Trang
AU - Stayner, Leslie
T1 - Evaluation of a safety training program in three food service companies.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2003///
VL - 34
IS - 5
SP - 547
EP - 558
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Sinclair, Raymond C., National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS C-10, Cincinnati, OH, US, 45226
N1 - Accession Number: 2004-10783-009. PMID: 14733989 Partial author list: First Author & Affiliation: Sinclair, Raymond C.; National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, US. Release Date: 20040906. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Industrial Accidents; Occupational Safety; Personnel Training. Minor Descriptor: Injuries. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: 2003.
AB - Outcome measures for safety training effectiveness research often do not include measures such as occupational injury experience. Effectiveness mediators also receive sparse attention. A new safety training curriculum was delivered to workers in a stratified random sample of food service facilities across three companies. A similar group of facilities received usual training. We collected post-test measures of demographic variables, safety knowledge, perceptions of transfer of training climate, and workers' compensation claim data for one year after the initial training activities. Knowledge test scores were apparently higher in the new-training units than in the usual-training units. Some demographic variables were inconsistently associated with these differences. We found evidence that safety training increases knowledge and reduces injuries. We found almost no evidence of effects of training effectiveness mediators, including no relationship between safety knowledge and injury experience. Methodological issues related to conducting a large study may have influenced these results. Although safety training leads to greater knowledge and, in some cases, reduced occupational injuries, the influence of mediating variables remains to be fully explained. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - safety training program
KW - food services companies
KW - occupational injury
KW - 2003
KW - Industrial Accidents
KW - Occupational Safety
KW - Personnel Training
KW - Injuries
KW - 2003
DO - 10.1016/j.jsr.2003.03.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10783-009&site=ehost-live&scope=site
UR - Rsinclair@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11129-020
AN - 2004-11129-020
AU - Blyler, Crystal R.
T1 - Commentary: Service System Perspectives on Early Intervention Research.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 2003///
VL - 29
IS - 4
SP - 867
EP - 875
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - Blyler, Crystal R., SAMHSA Ctr for Mental Health Services, 5600 Fishers Lane, Room 11C-22, Rockville, MD, US, 20857
N1 - Accession Number: 2004-11129-020. PMID: 14989421 Partial author list: First Author & Affiliation: Blyler, Crystal R.; SAMHSA Ctr for Mental Health Services, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20040405. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Disease Course; Early Intervention; Experimentation; Mental Health Services; Schizophrenia. Minor Descriptor: Mental Disorders; Severity (Disorders). Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: 2003.
AB - Comments on the articles in this issue of the Schizophrenia Bulletin regarding the schizophrenia prodrome and early intervention research. Specifically, the author discusses two important topics, including 1) critical issues for translating science to service, and 2) issues in developing a multisite approach to early serious mental illness research. As a representative of a Government agency that funds mental health services and that has a role in shaping and funding policy initiatives in the US, the author suggests that few areas of schizophrenia research are as exciting as the prospects engendered by the studies on early intervention described in this special issue. She concludes that by acting now and thinking ahead to the possibilities for widespread dissemination of intervention models, early intervention research can have a quick and lasting impact on the future of the mental health service system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia prodrome
KW - early intervention research
KW - serious mental illness research
KW - multisite approach
KW - mental health services
KW - 2003
KW - Disease Course
KW - Early Intervention
KW - Experimentation
KW - Mental Health Services
KW - Schizophrenia
KW - Mental Disorders
KW - Severity (Disorders)
KW - 2003
DO - 10.1093/oxfordjournals.schbul.a007053
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11129-020&site=ehost-live&scope=site
UR - cblyler@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05485-006
AN - 2003-05485-006
AU - Westergaard, Gregory C.
AU - Suomi, Stephen J.
AU - Chavanne, Tara J.
AU - Houser, Lisa
AU - Hurley, Anne
AU - Cleveland, Allison
AU - Snoy, Philip J.
AU - Higley, J. Dee
T1 - Physiological correlates of aggression an impulsivity in free-ranging female primates.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2003///
VL - 28
IS - 6
SP - 1045
EP - 1055
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
AD - Westergaard, Gregory C., Div of Research, LABS of Virginia, Inc., 95 Castle Hall Road, PO Box 557, Yemassee, SC, US, 29945
N1 - Accession Number: 2003-05485-006. PMID: 12700686 Partial author list: First Author & Affiliation: Westergaard, Gregory C.; LABS of Virginia, Inc, Div of Research & Development, Yemassee, SC, US. Release Date: 20030811. Correction Date: 20100510. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Aggressive Behavior; Animal Social Behavior; Impulsiveness; Metabolites; Risk Taking. Minor Descriptor: Blood Plasma; Cerebrospinal Fluid; Hormones; Monkeys; Serotonin Metabolites. Classification: Psychophysiology (2560). Population: Animal (20); Female (40). Methodology: Empirical Study. References Available: Y. Page Count: 11. Issue Publication Date: 2003.
AB - We examined the relations among cerebrospinal fluid (CSF) monoamine metabolite concentrations, plasma hormone concentrations, aggression, and impulsive risk-taking behavior in a free-ranging population of female rhesus macaques. We selected 44 juvenile female rhesus macaques as subjects from a population of approximately 3000 macaques that inhabit a 475-acre Sea Island. We obtained CSF and blood samples, and recorded behavioral observations over a subsequent 18-month period. Our results indicate an inverse correlation between CSF concentrations of the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the frequency of low-intensity restrained aggression typically associated with matrilineal defense of social status. In contrast, previous research with males has shown an inverse correlation between CSF 5-HIAA concentrations and levels of violent unstrained aggression typically associated with traumatic injury and death. We also noted a negative correlation between plasma concentrations of the stress hormone cortisol and the frequency of low-intensity aggressive acts. Further examination revealed a negative correlation between CSF 5-HIAA concentrations and the rate of long dangerous leaps through the forest canopy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cerebrospinal fluid monoamine metabolite concentratations
KW - plasma hormones
KW - aggression
KW - impulsive risk taking
KW - female rhesus macaques
KW - 2003
KW - Animal Aggressive Behavior
KW - Animal Social Behavior
KW - Impulsiveness
KW - Metabolites
KW - Risk Taking
KW - Blood Plasma
KW - Cerebrospinal Fluid
KW - Hormones
KW - Monkeys
KW - Serotonin Metabolites
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05485-006&site=ehost-live&scope=site
UR - gwprimate@netscape.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Back To The Future.
JO - Health Affairs
JF - Health Affairs
Y1 - 2003/01/02/2003 Supplement
VL - 22
IS - 1
M3 - Article
SP - 314
EP - 316
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - The paper by Brad Gray and colleagues summarizes a decade of challenge, growth, and evolution within what is now called the Agency for Healthcare Research and Quality (AHRQ) and the field of health services research, and it gives new depth to the old saying, "May you live in interesting times." Their assessment of the significance of the agency's reauthorization and description of continued challenges for AHRQ and the field are insightful. This commentary focuses on continued maturation of AHRQ's mission and focus, recent achievements, new external factors, and emerging policy dilemmas that AHRQ is uniquely poised to address. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL policy
KW - HEALTH planning
KW - MEDICAL care -- United States
KW - HEALTH services administration
KW - PUBLIC health administration
KW - UNITED States. Agency for Healthcare Research & Quality
KW - GRAY, Brad
N1 - Accession Number: 16605123; Clancy, Carolyn M. 1; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland; Source Info: 2003 Supplement, Vol. 22 Issue 1, p314; Subject Term: MEDICAL policy; Subject Term: HEALTH planning; Subject Term: MEDICAL care -- United States; Subject Term: HEALTH services administration; Subject Term: PUBLIC health administration; Company/Entity: UNITED States. Agency for Healthcare Research & Quality; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: GRAY, Brad; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106725138
T1 - Regulatory aspects of vascular dementia in the United States.
AU - Oliva A
AU - Mani R
AU - Katz R
AU - Oliva, Armando
AU - Mani, Ranjit
AU - Katz, Russell
Y1 - 2003/01/02/2003 Supplement 1
N1 - Accession Number: 106725138. Language: English. Entry Date: 20040416. Revision Date: 20161117. Publication Type: journal article. Supplement Title: 2003 Supplement 1. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9007918.
KW - Cerebrovascular Disorders -- Etiology
KW - Dementia -- Complications
KW - Dementia -- Diagnosis
KW - Drug Design
KW - Alzheimer's Disease
KW - United States Food and Drug Administration
SP - 293
EP - 295
JO - International Psychogeriatrics
JF - International Psychogeriatrics
JA - INT PSYCHOGERIATR
VL - 15
PB - Cambridge University Press
AB - There is significant interest in the development of new drugs to treat vascular dementia. However, before US approval of new drugs for this entity is possible, certain issues with regulatory implications need to be addressed. Is vascular dementia a distinct clinical syndrome with valid diagnostic criteria? Can this entity be distinguished from Alzheimer's disease (AD) and other causes of dementia? What design features are important for clinical trials in this disorder? The US Food and Drug Administration (FDA) convened a special meeting of the Peripheral and Central Nervous System Advisory Committee in an attempt to answer these questions. The conclusions from this meeting indicate that vascular dementia (VaD) is a pathologically heterogeneous disorder but appears to be reasonably distinguishable from AD dementia. The NINDS-AIREN diagnostic criteria are suitable as entry criteria for vascular dementia trials. Trials should be similar in duration to AD dementia trials and should employ a dual outcome strategy (cognitive + global/functional measures). For drugs that are believed to have a disease-modifying effect, clinical trials should study specific vascular dementia subtypes and would need to employ substantially different designs from those used currently. The term "vascular dementia" may not be entirely appropriate to describe this population.
SN - 1041-6102
AD - Division of Neuropharmacological Drug Products, US Food and Drug Administration, Rockville, MD 20857, USA
AD - US Food and Drug Administration, 5600 Fishers Lane, JFD-120, Rockville, MD 20857; olivaa@cder.fda.gov
U2 - PMID: 16191257.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Babu, U.
AU - Scott, M.
AU - Myers, M.J.
AU - Okamura, M.
AU - Gaines, D.
AU - Yancy, H.F.
AU - Lillehoj, H.
AU - Heckert, R.A.
AU - Raybourne, R.B.
T1 - Effects of live attenuated and killed Salmonella vaccine on T-lymphocyte mediated immunity in laying hens
JO - Veterinary Immunology & Immunopathology
JF - Veterinary Immunology & Immunopathology
Y1 - 2003/01/10/
VL - 91
IS - 1
M3 - Article
SP - 39
SN - 01652427
AB - The impact of live and killed Salmonella vaccines on cell-mediated immunity (CMI) was investigated in 18- and 32-week-old White Leghorn chickens, by assessing splenic lymphocyte proliferation, expression of IL-2 mRNA in concanavalin A (Con A) stimulated cells and flow cytometric analysis of cell subpopulations. Con A and Salmonella enteritidis (SE) flagella induced proliferation of splenocytes were enhanced in the 18- and 32-week-old chickens treated with live vaccine, compared to the corresponding control chickens. Among the killed vaccine treated birds, Con A-mediated response was higher in the 18-week-old chickens compared to the corresponding control birds. Increased proliferation was accompanied by increased CD4 and reduced CD8 and γδ T-lymphocytes in the 18-week-old live vaccine treated chickens. Relative expression of IL-2 mRNA in Con A-stimulated splenocytes from 18-week-old birds was not affected by vaccine treatment. Overall, live vaccine was more effective in increasing the lymphocyte proliferation to Con A as well as SE antigen. This enhanced CMI may prove beneficial in protecting chickens against SE infection. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Immunology & Immunopathology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - VACCINES
KW - α
KW - β
KW - δ
KW - γ
KW - CD4+
KW - CD8+
KW - Con A
KW - Flagella
KW - Proliferation
KW - Splenic lymphocytes
KW - T-cells
KW - Vaccines
KW - Salmonella enteritidis
N1 - Accession Number: 8762493; Babu, U. 1; Email Address: usb@cfsan.fda.gov Scott, M. 2 Myers, M.J. 2 Okamura, M. 3 Gaines, D. 1 Yancy, H.F. 2 Lillehoj, H. 3 Heckert, R.A. 4 Raybourne, R.B. 1; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301, Muirkirk Road HFS 326, Laurel, MD 20708, USA 2: US Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA 3: Parasite Biology, Epidemiology, Systematics Laboratory, Animal and Natural Resources Institute, US Department of Agriculture, Agricultural Research Service, Building 1040, BARC-East, Beltsville, MD 20705, USA 4: US Department of Agriculture, Agricultural Research Service, National Program Staff, Animal Production, Product Value and Safety, 5601 Sunnyside Ave, GWCC 4-2176, Beltsville, MD 20705-5138, USA; Source Info: Jan2003, Vol. 91 Issue 1, p39; Subject Term: SALMONELLA enteritidis; Subject Term: VACCINES; Author-Supplied Keyword: α; Author-Supplied Keyword: β; Author-Supplied Keyword: δ; Author-Supplied Keyword: γ; Author-Supplied Keyword: CD4+; Author-Supplied Keyword: CD8+; Author-Supplied Keyword: Con A; Author-Supplied Keyword: Flagella; Author-Supplied Keyword: Proliferation; Author-Supplied Keyword: Splenic lymphocytes; Author-Supplied Keyword: T-cells; Author-Supplied Keyword: Vaccines; Author-Supplied Keyword: Salmonella enteritidis; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuan, Bao-Zhu
AU - Durkin, Marian E.
AU - Popescu, Nicholas C.
T1 - Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers
JO - Cancer Genetics & Cytogenetics
JF - Cancer Genetics & Cytogenetics
Y1 - 2003/01/15/
VL - 140
IS - 2
M3 - Article
SP - 113
SN - 01654608
AB - Aberrant methylation of CpG islands within the promoter regions of tumor suppressor or cancer-related genes is a common mechanism leading to the silencing of gene expression. To determine whether aberrant methylation is a contributing factor to transcriptional inactivation of DLC-1 (deleted in liver cancer-1), a candidate tumor suppressor gene, we examined its methylation status in twelve hepatocellular carcinoma, breast, colon, and prostate tumor cell lines with low or undetectable expression of DLC-1. By Southern blot analysis of DNA digested with the methylation sensitive enzyme HpaII, we found a different degree of promoter hypermethylation in all cell lines with aberrant DLC-1 expression. The hypermethylation status was reversed by the addition of 5-aza-2′-deoxycytidine, a demethylating agent, in one human hepatocellular carcinoma line. These observations suggest that hypermethylation is responsible for abrogating the function of the DLC-1 gene in a subset of liver, breast, colon, and prostate cancers. [Copyright &y& Elsevier]
AB - Copyright of Cancer Genetics & Cytogenetics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIONCOGENES
KW - GENE expression
N1 - Accession Number: 9342418; Yuan, Bao-Zhu 1 Durkin, Marian E. 2 Popescu, Nicholas C. 2; Email Address: popescun@mail.nih.gov; Affiliation: 1: Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Laboratory of Experimental Carcinogenesis, Building 37 Room 3C05, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Jan2003, Vol. 140 Issue 2, p113; Subject Term: ANTIONCOGENES; Subject Term: GENE expression; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wamer, Wayne G.
AU - Vath, Peter
AU - Falvey, Daniel E.
T1 - In vitro studies on the photobiological properties of aloe emodin and aloin A
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2003/01/15/
VL - 34
IS - 2
M3 - Article
SP - 233
SN - 08915849
AB - Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics. Since a recent study indicated that topically applied aloe emodin increases the sensitivity of skin to UV light, we examined the events following photoexcitation of aloin A and aloe emodin. We determined that incubation of human skin fibroblasts with 20 μM aloe emodin for 18 h followed by irradiation with UV or visible light resulted in significant photocytotoxicity. This photocytotoxicity was accompanied by oxidative damage in both cellular DNA and RNA. In contrast, no photocytotoxicity was observed following incubation with up to 500 μM aloin A and irradiation with UVA light. In an attempt to explain the different photobiological properties of aloin A and aloe emodin, laser flash photolysis experiments were performed. We determined that the triplet state of aloe emodin was readily formed following photoexcitation. However, no transient intermediates were formed following photoexcitation of aloin A. Therefore, generation of reactive oxygen species and oxidative damage after irradiation of aloin A is unlikely. Although aloin A was not directly photocytotoxic, we found that human skin fibroblasts can metabolize aloin A to aloe emodin. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALOIN
KW - ANTHRAQUINONES
KW - LAXATIVES
KW - Aloe emodin
KW - Aloin
KW - Free radicals
KW - Metabolism
KW - Oxidation
KW - Phototoxicity
KW - UV
N1 - Accession Number: 8805044; Wamer, Wayne G. 1; Email Address: wwamer@cfsan.fda.gov Vath, Peter 2 Falvey, Daniel E. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA 2: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA; Source Info: Jan2003, Vol. 34 Issue 2, p233; Subject Term: ALOIN; Subject Term: ANTHRAQUINONES; Subject Term: LAXATIVES; Author-Supplied Keyword: Aloe emodin; Author-Supplied Keyword: Aloin; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Oxidation; Author-Supplied Keyword: Phototoxicity; Author-Supplied Keyword: UV; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 106825672
T1 - Medicare quality improvement: bad apples or bad systems?
AU - Hsia DC
AU - Hsia, David C
Y1 - 2003/01/15/
N1 - Accession Number: 106825672. Language: English. Entry Date: 20030425. Revision Date: 20161112. Publication Type: commentary; editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Medicare -- United States
KW - Quality Improvement -- United States
KW - Quality of Health Care -- United States
KW - Aged
KW - Clinical Indicators
KW - Medicare -- Standards
KW - United States
KW - United States Centers for Medicare and Medicaid Services
SP - 354
EP - 356
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 289
IS - 3
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Agency for Healthcare Research and Quality, 6010 Executive Blvd, Rockville, MD 20852-3809; dhsia@ahrq.gov
U2 - PMID: 12525237.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692066
T1 - Ensuring safe and effective medical devices.
AU - Feigal DW
AU - Gardner SN
AU - McClellan M
Y1 - 2003/01/16/
N1 - Accession Number: 106692066. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Device Approval
KW - Equipment and Supplies -- Standards
KW - Equipment Safety -- Standards
KW - Equipment and Supplies -- Adverse Effects
KW - United States
KW - United States Food and Drug Administration
SP - 191
EP - 192
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 348
IS - 3
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 12529457.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106692066&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106692070
T1 - Risks and benefits of gene therapy.
AU - Noguchi P
Y1 - 2003/01/16/
N1 - Accession Number: 106692070. Language: English. Entry Date: 20040116. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Gene Therapy -- Adverse Effects
KW - Leukemia, Lymphocytic -- Etiology
KW - Severe Combined Immunodeficiency -- Therapy
KW - Genetic Techniques
KW - T Lymphocytes
SP - 193
EP - 194
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 348
IS - 3
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Food and Drug Administration, Rockville, MD
U2 - PMID: 12529458.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106692070&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Ng, Jack C.
AU - Moore, Michael R.
AU - Shi, Xianglin
T1 - Special issue on environmental toxicology of metals and metalloids
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2003/01/31/
VL - 137
IS - 1/2
M3 - Editorial
SP - 1
SN - 03784274
N1 - Accession Number: 8723295; Ng, Jack C. 1; Moore, Michael R. 1; Shi, Xianglin 2; Affiliations: 1: National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, 39 Kessels Road, Coopers Plains, Brisbane, Qld 4108, Australia; 2: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Issue Info: Jan2003, Vol. 137 Issue 1/2, p1; Number of Pages: 1p; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Caudill, Samantha
AU - Goldman, Thurma
AU - Marconi, Katherine
T1 - Evaluation of Pediatric HIV Care Provided in Ryan White CARE Act Title IV Women, Infants, Children, and Youth Clinics.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2003/02//
VL - 17
IS - 2
M3 - Article
SP - 65
EP - 73
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - This evaluation examines the changing practices and outcomes of pediatric HIV care provided by the Ryan White Comprehensive AIDS Resources and Emergency (CARE) Act, Title IV grantees from 1996 through 1998—a period of rapidly changing medical practice within the United States. Using medical chart abstraction, 26 Title IV grantees reported information from the records of 525 HIV positive clients between the ages of 2 and 12. The chart abstractions covered medical care and case management provided to these clients including the number of clinical visits, use of antiretroviral therapy, use of laboratory tests such as CD4[sup +] cell count (cells/mm[sup 3]) and HIV-1 RNA viral load (copies/mL), enrollment in clinical trials, and receipt of opportunistic infection prophylaxis. Information on disease progression and hospitalization as well as client socio-demographic characteristics also is analyzed. Study results indicate that use of HIV combination therapy increased, while the occurrence of opportunistic infections and hospitalizations decreased. The increasing use of new pharmaceuticals during the study period indicates the feasibility of transferring information learned about HIV treatments from clinical trials to clinical practices that treat primarily Medicaid and pediatric populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pediatrics -- Practice
KW - HIV infections
KW - United States
N1 - Accession Number: 9132938; Caudill, Samantha 1; Goldman, Thurma 1; Marconi, Katherine 1; Affiliations: 1: Department of Health and Human Services, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Maryland; Issue Info: Feb2003, Vol. 17 Issue 2, p65; Subject Term: Pediatrics -- Practice; Subject Term: HIV infections; Subject: United States; Number of Pages: 9p; Document Type: Article
L3 - 10.1089/108729103321150791
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9132938&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106880005
T1 - Evaluation of pediatric HIV care provided in Ryan White CARE Act Title IV women, infants, children, and youth clinics.
AU - Caudill S
AU - Goldman T
AU - Marconi K
Y1 - 2003/02//
N1 - Accession Number: 106880005. Language: English. Entry Date: 20050507. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - Health Care Delivery -- Legislation and Jurisprudence -- United States
KW - Health Services Accessibility -- In Infancy and Childhood -- United States
KW - HIV Infections -- Drug Therapy -- In Infancy and Childhood
KW - Pediatric Care -- Evaluation
KW - Quality of Health Care -- Evaluation -- In Infancy and Childhood
KW - AIDS-Related Opportunistic Infections
KW - Antiviral Agents
KW - CD4 Lymphocyte Count
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Disease Progression
KW - Evaluation Research
KW - Female
KW - Health Status
KW - Hematologic Tests
KW - Hospitalization
KW - Legislation
KW - Male
KW - Medicaid
KW - Medical Records
KW - Medically Underserved Area
KW - Record Review
KW - Sample Size
KW - Stratified Random Sample
KW - Two-Tailed Test
KW - United States
KW - Viral Load
KW - Human
SP - 65
EP - 73
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 17
IS - 2
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - This evaluation examines the changing practices and outcomes of pediatric HIV care provided by the Ryan White Comprehensive AIDS Resources and Emergency (CARE) Act, Title IV grantees from 1996 through 1998--a period of rapidly changing medical practice within the United States. Using medical chart abstraction, 26 Title IV grantees reported information from the records of 525 HIV positive clients between the ages of 2 and 12. The chart abstractions covered medical care and case management provided to these clients including the number of clinical visits, use of antiretroviral therapy, use of laboratory tests such as CD4+ cell count (cells/mm3) and HIV-1 RNA viral load (copies/mL), enrollment in clinical trials, and receipt of opportunistic infection prophylaxis. Information on disease progression and hospitalization as well as client socio-demographic characteristics also is analyzed. Study results indicate that use of HIV combination therapy increased, while the occurrence of opportunistic infections and hospitalizations decreased. The increasing use of new pharmaceuticals during the study period indicates the feasibility of transferring information learned about HIV treatments from clinical trials to clinical practices that treat primarily Medicaid and pediatric populations.
SN - 1087-2914
AD - Dept of Health and Human Services, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, MD
U2 - PMID: 12639289.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106880005&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ashley, Olivia Silber
AU - Marsden, Mary Ellen
AU - Brady, Thomas M.
T1 - Effectiveness Of Substance Abuse Treatment Programming For Women: A Review†.
JO - American Journal of Drug & Alcohol Abuse
JF - American Journal of Drug & Alcohol Abuse
Y1 - 2003/02//
VL - 29
IS - 1
M3 - Article
SP - 19
PB - Taylor & Francis Ltd
SN - 00952990
AB - Recent research has shown that women and men differ in substance abuse etiology, disease progression, and access to treatment for substance abuse. Substance abuse treatment specifically designed for women has been proposed as one way to meet women's distinctive needs and reduce barriers to their receiving and remaining in treatment. However, relatively few substance abuse treatment programs offer specialized services for women, and effectiveness has not been fully evaluated. This article reviews the literature on the extent and effectiveness of substance abuse treatment programming for women and provides an overview of what is known about the components of successful treatment programs for women. Thirty-eight studies of the effect on treatment outcomes of substance abuse treatment programming for women were reviewed. Seven were randomized, controlled trials, and 31 were nonrandomized studies. In our review, six components of substance abuse treatment programming for women were examined: child care, prenatal care, women-only programs, supplemental services and workshops that address women-focused topics, mental health programming, and comprehensive programming. The studies found positive associations between these six components and treatment completion, length of stay, decreased use of substances, reduced mental health symptoms, improved birth outcomes, employment, self-reported health status, and HIV risk reduction. These findings suggest that to improve the future health and well-being of women and their children, there is a continued need for well-designed studies of substance abuse treatment programming for women. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - WOMEN -- Substance use
KW - DRUG use testing
KW - EMPLOYEE assistance programs
KW - PERSONALITY disorders
KW - MENTAL health
N1 - Accession Number: 9389419; Ashley, Olivia Silber 1; Email Address: osilber@rti.org. Marsden, Mary Ellen 1 Brady, Thomas M. 2; Affiliation: 1: RTI, Research Triangle Park, North Carolina, USA. 2: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA.; Source Info: Feb2003, Vol. 29 Issue 1, p19; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: WOMEN -- Substance use; Subject Term: DRUG use testing; Subject Term: EMPLOYEE assistance programs; Subject Term: PERSONALITY disorders; Subject Term: MENTAL health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 35p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burns, Drusilla L
T1 - Type IV transporters of pathogenic bacteria
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
Y1 - 2003/02//
VL - 6
IS - 1
M3 - Article
SP - 29
SN - 13695274
AB - Type IV transporters are produced by several bacterial pathogens such as Agrobacterium tumefaciens, Bordetella pertussis, Brucella spp., Bartonella henselae, Helicobacter pylori and Legionella pneumophila. These transporters are critical for the pathogenic process in that they export important virulence factors across the membranes of the bacteria. Although the virulence factors that are exported by these transporters can be either nucleic acid or protein, the general mechanism of transport appears to be similar for members of this family. Recent findings have shed light on the architecture of type IV transporters and the roles that these transporters play in pathogenesis. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIA
KW - PATHOGENIC microorganisms
KW - LEGIONELLA pneumophila
N1 - Accession Number: 9193637; Burns, Drusilla L 1; Email Address: burns@cber.fda.gov; Affiliation: 1: United States Food and Drug Administration HFM-434 Building 29, Room 130, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Feb2003, Vol. 6 Issue 1, p29; Subject Term: BACTERIA; Subject Term: PATHOGENIC microorganisms; Subject Term: LEGIONELLA pneumophila; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S1369-5274(02)00006-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Finkelstein, Eric A.
AU - Bray, Jeremy W.
AU - Hong Chen
AU - Hong Chen
AU - Larson, Mary Jo
AU - Miller, Kay
AU - Tompkins, Christopher
AU - Keme, Allen
AU - Manderscheid, Ronald
T1 - Prevalence and Costs of Major Depression Among Elderly Claimants With Diabetes.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2003/02//
VL - 26
IS - 2
M3 - Article
SP - 415
EP - 420
SN - 01495992
AB - OBJECTIVE — To compare the odds of major depression among Medicare claimants with and without diabetes and to test whether annual, medical payments are greater for those with both diabetes and major depression than for those with diabetes alone. RESEARCH DESIGN AND METHODS — This retrospective analysis relies on claims data from the 1997 Medicare 5% Standard Analytic Files. Using these data, we statistically determined whether the odds of major depression are greater among elderly claimants with diabetes after controlling for age, race/ethnicity, and sex. We then used regression analysis on a sample of over 220,000 elderly claimants with diabetes to test whether payments for non-mental health-related services are greater for those with both diabetes and major depression (n = 4,203) than for those with diabetes alone. RESULTS Our findings indicate that the odds of major depression are significantly greater among elderly Medicare claimants with diabetes than among those without diabetes (OR 1.58 ± 0.05). We also found that elderly claimants with both diabetes and major depression seek treatment for more services and spend more time in inpatient facilities, and as a result incur higher medical costs than claimants with diabetes but without major depression, These results hold even after excluding services related to mental health treatment. CONCLUSIONS This analysis suggests that treatment for major depression among claimants with diabetes may reduce total medical costs if treatment results in a decrease in utilization for general medical services in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - MENTAL depression
N1 - Accession Number: 9067284; Finkelstein, Eric A. 1; Email Address: finkelse@rti.org Bray, Jeremy W. Hong Chen Hong Chen 1 Larson, Mary Jo 2 Miller, Kay 3 Tompkins, Christopher 4 Keme, Allen 5 Manderscheid, Ronald 1; Affiliation: 1: RTI, Research Triangle Park, North Carolina 2: New England Research Institutes, Watertown, Massachusetts 3: The Medstat Group, Santa Barbara, California 4: Brandeis University, Waltham, Massachusetts 5: Substance Abuse and Mental Health Services Administration, Rockville, Maryland; Source Info: Feb2003, Vol. 26 Issue 2, p415; Subject Term: DIABETES; Subject Term: MENTAL depression; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 4270
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mehta, Arpita I.
AU - Ross, Sally
AU - Lowenthal, Mark S.
AU - Fusaro, Vincent
AU - Fishman, David A.
AU - Petricoin III, Emanuel F.
AU - Liotta, Lance A.
T1 - Biomarker amplification by serum carrier protein binding.
JO - Disease Markers
JF - Disease Markers
Y1 - 2003/02//2003/2004
VL - 19
IS - 1
M3 - Article
SP - 1
EP - 10
PB - Hindawi Publishing Corporation
SN - 02780240
AB - Mass spectroscopic analysis of the low molecular mass (LMM) range of the serum/plasma proteome is a rapidly emerging frontier for biomarker discovery. This study examined the proportion of LMM biomarkers, which are bound to circulating carrier proteins. Mass spectroscopic analysis of human serum following molecular mass fractionation, demonstrated that the majority of LMM biomarkers exist bound to carrier proteins. Moreover, the pattern of LMM biomarkers bound specifically to albumin is distinct from those bound to non-albumin carriers. Prominent SELDI-TOF ionic species (m/z 6631.7043) identified to correlate with the presence of ovarian cancer were amplified by albumin capture. Several insights emerged: a) Accumulation of LMM biomarkers on circulating carrier proteins greatly amplifies the total serum/plasma concentration of the measurable biomarker, b) The total serum/plasma biomarker concentration is largely determined by the carrier protein clearance rate, not the unbound biomarker clearance rate itself, and c) Examination of the LMM species bound to a specific carrier protein may contain important diagnostic information. These findings shift the focus of biomarker detection to the carrier protein and its biomarker content. [ABSTRACT FROM AUTHOR]
AB - Copyright of Disease Markers is the property of Hindawi Publishing Corporation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPECTROSCOPIC imaging
KW - SERUM
KW - BIOCHEMICAL markers
KW - CARRIER proteins
KW - ALBUMINS
KW - OVARIAN diseases
N1 - Accession Number: 12084619; Mehta, Arpita I. 1,2; Email Address: arpita.mehta@tufts.edu Ross, Sally 2,3 Lowenthal, Mark S. 2 Fusaro, Vincent 2,3 Fishman, David A. 4 Petricoin III, Emanuel F. 2 Liotta, Lance A. 2; Affiliation: 1: NIH-Howard Hughes Research Scholar, Howard Hughes Medical Institute, Bethesda, MD, USA 2: FDA-NCI Clinical Proteomics Program, Office of the Director, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 3: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 4: National Ovarian Cancer Early Detection Program, Northwestern University Medical School, Chicago, IL, USA; Source Info: 2003/2004, Vol. 19 Issue 1, p1; Subject Term: SPECTROSCOPIC imaging; Subject Term: SERUM; Subject Term: BIOCHEMICAL markers; Subject Term: CARRIER proteins; Subject Term: ALBUMINS; Subject Term: OVARIAN diseases; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mulvey, Kevin P.
AU - Hayashi, Susan W.
AU - Hubbard, Susan M.
AU - Kopstien, Andrea
AU - Huang, Judy Y.
T1 - The TIPS evaluation project: a theory-driven approach to dissemination research
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2003/02//
VL - 26
IS - 1
M3 - Article
SP - 45
SN - 01497189
AB - This editorial introduces the special issue of Evaluation and Program Planning. This issue focuses on four major studies under the treatment improvement protocols (TIPs) evaluation project sponsored by the Center for Substance Abuse Treatment. The goal of these evaluation studies was to gain a better understanding of the effectiveness of TIPs in influencing attitudes and behaviors, the people who are most effective in transmitting new practice guidelines, the barriers to implementation, and the methods that would best transfer information into action. In addition to providing an overview of each article, this introduction addresses the value of using a theory-driven approach to dissemination research. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - THERAPEUTICS
KW - Diffusion of innovations theory
KW - Diffusion theory
KW - Dissemination research
KW - Evaluation
KW - Substance abuse
KW - Substance abuse treatment
KW - Theory-driven evaluations
KW - Treatment improvement protocols
N1 - Accession Number: 9051141; Mulvey, Kevin P. 1; Email Address: kmulvey@samhsa.gov; Hayashi, Susan W. 2; Hubbard, Susan M. 2; Kopstien, Andrea 1; Huang, Judy Y. 2; Affiliations: 1: Center for Substance Abuse Treatment, SAMHSA, 5515 Security Lane, Rockwall II Suite 8-180, Rockville, MD 20852, USA; 2: Johnson, Bassin & Shaw, Inc., Silver Spring, MD, USA; Issue Info: Feb2003, Vol. 26 Issue 1, p45; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Diffusion of innovations theory; Author-Supplied Keyword: Diffusion theory; Author-Supplied Keyword: Dissemination research; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Theory-driven evaluations; Author-Supplied Keyword: Treatment improvement protocols; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hubbard, Susan M.
AU - Mulvey, Kevin P.
T1 - TIPs evaluation project retrospective study: wave 1 and 2
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2003/02//
VL - 26
IS - 1
M3 - Article
SP - 57
SN - 01497189
AB - The retrospective study is the first study of the treatment improvement protocols (TIPs) evaluation project sponsored by the Center for Substance Abuse Treatment (CSAT). This study employs a two-wave cross-sectional survey that measured substance abuse (SA) treatment professionals'' knowledge (i.e. awareness), attitudes, and practices regarding the TIP series and the 28 specific TIPs, which were disseminated at study implementation. Diffusion theory () is used as the conceptual framework for the study. Results indicate that almost half of all treatment professionals are aware of TIPs, that attitudes towards TIPs are positive, yet treatment professionals report difficulty in using TIPs in practice. Results are used to make recommendations to improve the development and dissemination of TIPs. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - THERAPEUTICS
KW - Best practice guidelines
KW - Diffusion of innovations theory
KW - Diffusion theory
KW - Evaluation
KW - Mixed mode survey design
KW - Substance abuse
KW - Substance abuse treatment
KW - Substance abuse treatment providers
KW - Survey research
KW - Total design method
KW - Treatment Improvement Protocols (TIPs)
N1 - Accession Number: 9051143; Hubbard, Susan M. 1; Email Address: shubbard@jbs1.com; Mulvey, Kevin P. 2; Affiliations: 1: Johnson, Bassin and Shaw, Inc. 8630 Fenton Street, 12th Floor, Silver Spring, MD 20910, USA; 2: Center for Substance Abuse Treatment, SAMHSA, Rockville, MD, USA; Issue Info: Feb2003, Vol. 26 Issue 1, p57; Subject Term: SUBSTANCE abuse; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Best practice guidelines; Author-Supplied Keyword: Diffusion of innovations theory; Author-Supplied Keyword: Diffusion theory; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Mixed mode survey design; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Substance abuse treatment providers; Author-Supplied Keyword: Survey research; Author-Supplied Keyword: Total design method; Author-Supplied Keyword: Treatment Improvement Protocols (TIPs); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Huang, Judy Y.
AU - Hubbard, Susan M.
AU - Mulvey, Kevin P.
T1 - Obtaining valid response rates: considerations beyond the tailored design method
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2003/02//
VL - 26
IS - 1
M3 - Article
SP - 91
SN - 01497189
AB - This study reports on the use of the tailored design method (TDM) for survey response in two separate studies (i.e. the Retrospective Study and the TIP #24 Study). Both studies used similar procedures to design and collect the data, but yielded vastly different response rates. Examination of these studies revealed factors that may have influenced the response rates beyond the proscriptions described by the TDM. Six factors that may have influenced non-response were: (1) the extent of participants'' interest in the study, (2) the degree the researchers had a comprehensive understanding of the participants, (3) the characteristics of the mailing lists obtained, (4) selection criteria from that list, (5) types of incentives used, and (6) name recognition of the study sponsor. This study provides researchers with lessons for future mailed surveys. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - MEDICAL protocols
KW - Mailed surveys
KW - Participant recruitment
KW - Primary care providers
KW - Problems in survey research
KW - Substance abuse
KW - Substance abuse treatment
KW - Substance abuse treatment providers
KW - Survey participation
KW - Survey response rate
KW - Tailored design method
KW - Treatment improvement protocols
KW - Use of incentives
N1 - Accession Number: 9051146; Huang, Judy Y. 1; Email Address: jhuang@jbs1.com; Hubbard, Susan M. 1; Mulvey, Kevin P. 2; Affiliations: 1: Johnson, Bassin & Shaw Inc., 8630 Fenton Street, 12th Floor, Silver Spring, MD 20910, USA; 2: Center for Substance Abuse Treatment, SAMHSA, Rockville, MD, USA; Issue Info: Feb2003, Vol. 26 Issue 1, p91; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: MEDICAL protocols; Author-Supplied Keyword: Mailed surveys; Author-Supplied Keyword: Participant recruitment; Author-Supplied Keyword: Primary care providers; Author-Supplied Keyword: Problems in survey research; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Substance abuse treatment providers; Author-Supplied Keyword: Survey participation; Author-Supplied Keyword: Survey response rate; Author-Supplied Keyword: Tailored design method; Author-Supplied Keyword: Treatment improvement protocols; Author-Supplied Keyword: Use of incentives; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hubbard, Susan M.
AU - Huang, Judy Y.
AU - Mulvey, Kevin P.
T1 - Application of diffusion of innovations theory to the TIPs evaluation project results and beyond
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2003/02//
VL - 26
IS - 1
M3 - Article
SP - 99
SN - 01497189
AB - This article provides an overall summary of the results from four major studies under the Treatment Improvement Protocols (TIPs) evaluation project. The diffusion of innovations theory is used as a theoretical framework to understand substance abuse treatment providers'' awareness, attitudes, and practices (or uses) of TIPs. Recommendations to improve the development and dissemination of TIPs are made. In addition, changes made to the TIPs program based on study findings are highlighted. All the studies within this project are structured around the diffusion of innovations theory framework and demonstrate the efficacy of theory-based program evaluation. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - MEDICAL protocols
KW - Development, dissemination, adoption, and implementation of best practice guidelines
KW - Diffusion of innovations theory
KW - Diffusion theory
KW - Evaluation
KW - Substance abuse
KW - Substance abuse treatment
KW - Substance abuse treatment providers
KW - Theory-based evaluation
KW - Treatment Improvement Protocols
N1 - Accession Number: 9051147; Hubbard, Susan M. 1; Email Address: shubbard@jbs1.com; Huang, Judy Y. 1; Mulvey, Kevin P. 2; Affiliations: 1: Johnson, Bassin and Shaw Inc., 8630 Fenton Street, 12th Floor, Silver Spring, MD 20910, USA; 2: Center for Substance Abuse Treatment, SAMHSA, Rockville, MD, USA; Issue Info: Feb2003, Vol. 26 Issue 1, p99; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: MEDICAL protocols; Author-Supplied Keyword: Development, dissemination, adoption, and implementation of best practice guidelines; Author-Supplied Keyword: Diffusion of innovations theory; Author-Supplied Keyword: Diffusion theory; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Substance abuse treatment providers; Author-Supplied Keyword: Theory-based evaluation; Author-Supplied Keyword: Treatment Improvement Protocols; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Walrath, Christine
AU - Ybarra, Michele
AU - Wayne Holden, E.
AU - Manteuffel, Brigitte
AU - Santiago, Rolando
AU - Leaf, Philip
T1 - Female offenders referred for community-based mental health service as compared to other service-referred youth: correlates of conviction
JO - Journal of Adolescence
JF - Journal of Adolescence
Y1 - 2003/02//
VL - 26
IS - 1
M3 - Article
SP - 45
SN - 01401971
AB - Data from a large federally supported national evaluation of system-of-care community mental health services were analysed to identify correlates of conviction. Female adolescents with a reported history of criminal conviction (n=88) were compared to three other service-referred youth groups: females without conviction histories (n=664), males with conviction histories (n=199), and males without conviction histories (n=1230) for possible differences in number and type of family, individual, and school-related life challenges. Multinomial regression analyses were first used to compare the quantity of child and family correlates in each conviction group, and then to test specific correlates in the individual, family, and school domains. The conditional odds of reporting a high vs. low number of child correlates was found to be significantly greater for females with a history of conviction compared to all other groups, over and above the number of family risk factors. Further, service-referred females with a conviction history, when compared to other service-referred youth groups, were much more likely to report having experienced a living instability (e.g. history of running away, multiple living arrangements) and personal adverse life events (e.g. history of drug and alcohol use, sexual abuse). Implications for community-based interventions and treatment are discussed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Adolescence is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health services
KW - WOMEN criminals
N1 - Accession Number: 8999825; Walrath, Christine 1 Ybarra, Michele 1 Wayne Holden, E. 2 Manteuffel, Brigitte 2 Santiago, Rolando 3 Leaf, Philip 1; Affiliation: 1: Department of Mental Hygiene, Bloomberg School of Public Health, John Hopkins University, Baltimore, MD 21202, USA 2: ORC Macro, Atlanta, GA, USA 3: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, USA; Source Info: Feb2003, Vol. 26 Issue 1, p45; Subject Term: MENTAL health services; Subject Term: WOMEN criminals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/S0140-1971(02)00113-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106783726
T1 - Human cargo: health conditions of Chinese migrants interdicted offshore by U.S. authorities.
AU - Schneider DL
AU - Steiner R
AU - Romaine J
Y1 - 2003/02//
N1 - Accession Number: 106783726. Language: English. Entry Date: 20031128. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7600747.
KW - Chinese
KW - Health Status
KW - Transients and Migrants
KW - Adolescence
KW - Adult
KW - Child
KW - China
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Emigration and Immigration
KW - Female
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - Record Review
KW - Sex Factors
KW - Statistical Significance
KW - United States
KW - Human
SP - 19
EP - 39
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 28
IS - 1
CY - ,
PB - Springer Science & Business Media B.V.
AB - During the eight month period between April and December 1999, the United States Coast Guard intercepted seven boats carrying migrants from the People's Republic of China destined for the United States. These migrants were processed by the United States Immigration and Naturalization Service in three locations: Tinian Island, Midway Island, and Guatemala. Emergency Medical Response Teams from the United States Public Health Service, Division of Immigration Health Services, were deployed to conduct initial health screenings of the 913 migrants on board these ships and provide on-going health care until the individuals were repatriated or relocated. The distributions of demographic characteristics of the population and the health conditions observed are presented. Differences in health conditions observed by temporary detention location, sex, and age group were assessed. The majority of migrants were males younger than age 30. Few serious illnesses were observed. The most prevalent conditions included skin rashes, fungal rashes, upper respiratory infections, abdominal discomfort, scabies, abrasions, skin lesions, headache, pain and/or injuries, dental problems, and ear problems. For many health conditions, statistically significant differences were observed by location. For nearly all conditions for which differences were observed by sex, these differences were accounted for by a greater proportion of females presenting with the condition.
SN - 0094-5145
AD - Health Resources and Services Administration, Bureau of Primary Health Care, Division of Immigration Health Services, Washington, DC; Diana.Schneider@usdoj.gov
U2 - PMID: 12570171.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nordstrom, Jessica L.
AU - DePaola, Angelo
T1 - Improved recovery of pathogenic Vibrio parahaemolyticus from oysters using colony hybridization following enrichment
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2003/02//
VL - 52
IS - 2
M3 - Article
SP - 273
SN - 01677012
AB - The traditional streak plating and alternative spread-plating methods were compared for detection of pathogenic Vibrio parahaemolyticus (Vp) in oyster enrichments. We found the alternative method to be more efficient: it was quicker (2d vs. 3d) and had a significantly (p<0.05) greater detection rate than streak plating. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA probes
KW - VIBRIO
KW - DNA probe
KW - tdh gene
KW - Vibrio parahaemolyticus
N1 - Accession Number: 8549313; Nordstrom, Jessica L.; Email Address: jessica.nordstrom@cfsan.fda.gov DePaola, Angelo 1; Affiliation: 1: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Post Office Box 158, Dauphin Island, AL 36528-0158, USA; Source Info: Feb2003, Vol. 52 Issue 2, p273; Subject Term: DNA probes; Subject Term: VIBRIO; Author-Supplied Keyword: DNA probe; Author-Supplied Keyword: tdh gene; Author-Supplied Keyword: Vibrio parahaemolyticus; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prince, Mary M.
AU - Gilbert, Stephen J.
AU - Smith, Randall J.
AU - Stayner, Leslie T.
T1 - Evaluation of the risk of noise-induced hearing loss among unscreened male industrial workers.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2003/02//
VL - 113
IS - 2
M3 - Article
SP - 871
EP - 880
SN - 00014966
AB - Variability in background risk and distribution of various risk factors for hearing loss may explain some of the diversity in excess risk of noise-induced hearing loss (NIHL). This paper examines the impact of various risk factors on excess risk estimates of NIHL using data from the 1968–1972 NIOSH Occupational Noise and Hearing Survey (ONHS). Previous analyses of a subset of these data focused on 1172 highly “screened” workers. In the current analysis, an additional 894 white males (609 noise-exposed and 285 controls), who were excluded for various reasons (i.e., nonoccupational noise exposure, otologic or medical conditions affecting hearing, prior occupational noise exposure) have been added (n=2066) to assess excess risk of noise-induced material impairment in an unscreened population. Data are analyzed by age, duration of exposure, and sound level (8-h TWA) for four different definitions of noise-induced hearing impairment, defined as the binaural pure-tone average (PTA) hearing threshold level greater than 25 dB for the following frequencies: (a) 1–4 kHz (PTA1234), (b) 1–3 kHz (PTA123), (c) 0.5, 1, and 2 kHz (PTA512), and (d) 3, 4, and 6 kHz (PTA346). Results indicate that populations with higher background risks of hearing loss may show lower excess risks attributable to noise relative to highly screened populations. Estimates of lifetime excess risk of hearing impairment were found to be significantly different between screened and unscreened population for noise levels greater than 90 dBA. Predicted age-related risk of material hearing impairment in the ONHS unscreened population was similar to that predicted from Annex B and C of ANSI S3.44 for ages less than 60 years. Results underscore the importance of understanding differential risk patterns for hearing loss and the use of appropriate reference (control) populations when evaluating risk of noise-induced hearing impairment among contemporary industrial populations. © 2003 Acoustical Society of America. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEAFNESS
KW - INDUSTRIAL workers
KW - SOUND
KW - NOISE
KW - RISK management in business
N1 - Accession Number: 19825886; Prince, Mary M. 1; Email Address: mmp3@cdc.gov Gilbert, Stephen J. 2 Smith, Randall J. 2 Stayner, Leslie T. 2; Affiliation: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226 2: Risk Evaluation Branch, Education and Information Division, National Institue for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226; Source Info: Feb2003, Vol. 113 Issue 2, p871; Subject Term: DEAFNESS; Subject Term: INDUSTRIAL workers; Subject Term: SOUND; Subject Term: NOISE; Subject Term: RISK management in business; Number of Pages: 10p; Illustrations: 4 Charts, 23 Graphs; Document Type: Article
L3 - 10.1121/1.1536635
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106829737
T1 - Comparison of mammography use by older black and white women.
AU - Han B
AU - Wells BL
AU - Primas M
Y1 - 2003/02//
N1 - Accession Number: 106829737. Language: English. Entry Date: 20030509. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062.
KW - Mammography -- Utilization -- In Old Age
KW - Surveys
KW - Logistic Regression
KW - Chi Square Test
KW - Blacks
KW - Whites
KW - Comparative Studies
KW - Multivariate Statistics
KW - Age Factors
KW - Race Factors
KW - Marital Status
KW - Educational Status
KW - Income
KW - Insurance, Health
KW - Health Behavior
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Human
SP - 203
EP - 212
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
VL - 51
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVES: To identify differences in the prevalence of ever having had a mammogram and having had a recent mammogram between older black and white women and to compare factors associated with mammography use in older black and white women. DESIGN: Data analysis and comparative study using nationally representative multistage sampling survey. SETTING: Data were obtained from the 1998 National Health Interview Survey. PARTICIPANTS: Four hundred forty-nine black and 3,328 white older women were examined. MEASUREMENTS: The outcome variables included never having had a mammogram (yes/no) and not having had a mammogram in the past 3 years (yes/no). RESULTS: The results of chi-square tests showed that older blacks were less likely to have ever had a mammogram than older whites, but there was no difference in having had a recent mammogram between older blacks and whites. After adjusting for other related factors, race was not related to mammography use in older blacks and whites. Health insurance was related to mammography use in older whites but not in older blacks. Family income was associated with never having had a mammogram in older whites but not in older blacks. Older blacks with less than 12 years of education were less likely to have had a mammogram (recently or ever) than older whites with less than 12 years of education. CONCLUSIONS: Even though race, per se, was not associated with mammography use in older black and white women, many barriers to mammography use between older black and white women were different or did not have similar effects. To promote mammography use in older black and white women, barriers need to be specifically targeted for each group to enhance the effectiveness of breast cancer screening programs.
SN - 0002-8614
AD - Division of Programs for Special Populations, Bureau of Primary Health Care, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, Maryland
U2 - PMID: 12558717.
DO - 10.1046/j.1532-5415.2003.51059.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Elkins, Karen L.
AU - Cowley, Siobhán C.
AU - Bosio, Catharine M.
T1 - Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2003/02//
VL - 5
IS - 2
M3 - Article
SP - 135
SN - 12864579
AB - The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bioterrorism
KW - Francisella tularensis
KW - B-lymphocytes
KW - Bacterial vaccines
KW - Immunity, natural
KW - Interferon type II
KW - Mice
KW - T-lymphocytes
N1 - Accession Number: 9291182; Elkins, Karen L.; Email Address: elkins@cber.fda.gov; Cowley, Siobhán C. 1; Bosio, Catharine M. 1; Affiliations: 1: Laboratory of Mycobacteria, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA; Issue Info: Feb2003, Vol. 5 Issue 2, p135; Thesaurus Term: Bioterrorism; Subject Term: Francisella tularensis; Author-Supplied Keyword: B-lymphocytes; Author-Supplied Keyword: Bacterial vaccines; Author-Supplied Keyword: Immunity, natural; Author-Supplied Keyword: Interferon type II; Author-Supplied Keyword: Mice; Author-Supplied Keyword: T-lymphocytes; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S1286-4579(02)00084-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ebrahim, Shahul H.
AU - Gfroerer, Joseph
T1 - Pregnancy-related substance use in the United States during 1996–1998
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2003/02//
VL - 101
IS - 2
M3 - Article
SP - 374
SN - 00297844
AB - : ObjectiveTo provide a baseline estimate of the national prevalence of pregnancy-related illicit drug use and abstinence rates.: MethodsWe analyzed data collected between 1996 and 1998 from the National Household Survey on Drug Abuse, a nationally representative sample survey of 22,303 noninstitutionalized women aged 18–44 years, of whom 1249 were pregnant.: ResultsDuring 1996–1998, 6.4% of nonpregnant women of childbearing age and 2.8% of pregnant women reported that they used illicit drugs. Of the women who used drugs, the relative proportion of women who abstained from illicit drugs after recognition of pregnancy increased from 28% during the first trimester of pregnancy to 93% by the third trimester. However, because of postpregnancy relapse, the net pregnancy-related reduction in illicit drug use at postpartum was only 24%. Marijuana accounted for three-fourths of illicit drug use, and cocaine accounted for one-tenth of illicit drug use. Of those who used illicit drugs, over half of pregnant and two-thirds of nonpregnant women also used cigarettes and alcohol. Among the sociodemographic subgroups, pregnant and nonpregnant women who were young (18–30 years) or unmarried, and pregnant women with less than high school education had the highest rates of illicit drug use.: ConclusionThe continued burden of illicit drug use during pregnancy calls for policy efforts to enable primary care providers to identify and refer women who use substances to treatment and support services. Prevention of uptake of illicit drug use should be an integral part of public health programs for young women. [Copyright &y& Elsevier]
AB - Copyright of Obstetrics & Gynecology is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANCY
N1 - Accession Number: 9159842; Ebrahim, Shahul H. 1; Email Address: sebrahim@cdc.gov Gfroerer, Joseph 2; Affiliation: 1: Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA; Source Info: Feb2003, Vol. 101 Issue 2, p374; Subject Term: SUBSTANCE abuse; Subject Term: PREGNANCY; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0029-7844(02)02588-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, George L.
T1 - Regulation of Yellow Pigment Formation in Mice: A Historical Perspective.
JO - Pigment Cell Research
JF - Pigment Cell Research
Y1 - 2003/02//
VL - 16
IS - 1
M3 - Article
SP - 2
EP - 15
PB - Wiley-Blackwell
SN - 08935785
AB - Pigment synthesis by hair follicle melanocytes is modulated by a large number of environmental and genetic factors, many of which are discussed in this review. Eumelanic (non-yellow) pigment is produced by hair follicle melanocytes following the binding of alpha-melanocyte stimulating hormone to melanocortin receptor 1. Binding of this hormone to the melanocyte membrane is blocked by agouti signaling protein (ASP) which is encoded by the agouti locus and results in the synthesis of yellow pigment, instead of non-yellow (black/brown) pigment. The cyclical release of ASP by hair follicle cells results in a black/brown hair with a subapical yellow band. This is the wild-type coat color pattern of many mammals and is called agouti. Several dominant mutations at the agouti locus in mice, induced by retrotransposon-like intracisternal A particles, result in ectopic over-expression of ASP and animals with much higher proportions of all-yellow hairs. This abnormal presence of ASP in essentially all body cells results in the ‘yellow agouti obese mouse syndrome.’ The obesity has been associated with binding of ASP to melanocortin receptor 4 inactivating the latter. The syndrome also includes hyperinsulinemia, increased somatic growth, and increased susceptibility to hyperplasia and carcinogenesis. The physiologic and molecular bases for these syndrome components have not yet been elucidated. This historically orientated review is subdivided, where applicable, into pre- and post-1992 subsections to emphasize the impact of the cloning of the agouti and extension loci and their protein products on the identification of the molecular and physiological pathways modulating the manifold aspects of pheomelanogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pigment Cell Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL coloration
KW - HAIR follicles
KW - MELANOCYTES
KW - Agouti signaling protein
KW - Cysteine
KW - Growth
KW - Melanocortin receptors
KW - Obesity
N1 - Accession Number: 8875753; Wolff, George L. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079 and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Source Info: Feb2003, Vol. 16 Issue 1, p2; Subject Term: ANIMAL coloration; Subject Term: HAIR follicles; Subject Term: MELANOCYTES; Author-Supplied Keyword: Agouti signaling protein; Author-Supplied Keyword: Cysteine; Author-Supplied Keyword: Growth; Author-Supplied Keyword: Melanocortin receptors; Author-Supplied Keyword: Obesity; Number of Pages: 14p; Document Type: Article
L3 - 10.1034/j.1600-0749.2003.00012.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nawaz, M.S.
AU - Khan, S.A.
AU - Khan, A.A.
AU - Nayak, R.
AU - Steele, R.
AU - Paine, D.
AU - Jones, R.
T1 - Molecular Characterization of Fluoroquinolone-Resistant Campylobacter spp. Isolated from Poultry.
JO - Poultry Science
JF - Poultry Science
Y1 - 2003/02//
VL - 82
IS - 2
M3 - Article
SP - 251
EP - 258
SN - 00325791
AB - Focuses on campylobacteriosis, an infectious disease afflicting chickens caused by Campylobacter jejuni and Campylobacter coli and treated by fluoroquinolone antibiotics in clinical practices. Use of the drugs in animal husbandry which may select for fluoroquinolone-resistant campylobacters and compromise the clinical treatment of the infection; Morphological and biochemical characteristics of fluoroquinolone-resistant campylobacters isolated from poultry samples.
KW - CAMPYLOBACTER infections in poultry
KW - CAMPYLOBACTER jejuni
KW - BACTERIAL diseases in poultry
KW - CHICKENS -- Diseases
N1 - Accession Number: 10907242; Nawaz, M.S. 1; Email Address: mnawaz@nctr.fda.gov Khan, S.A. 1 Khan, A.A. 1 Nayak, R. 1 Steele, R. 1 Paine, D. 1 Jones, R. 2; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration (FDA), Arkansas 2: Division of Epidemiology, Center for Veterinary Medicine, Washington, DC; Source Info: Feb2003, Vol. 82 Issue 2, p251; Subject Term: CAMPYLOBACTER infections in poultry; Subject Term: CAMPYLOBACTER jejuni; Subject Term: BACTERIAL diseases in poultry; Subject Term: CHICKENS -- Diseases; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 8p; Illustrations: 7 Black and White Photographs, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coleman, Margaret E.
AU - Sandberg, Sonja
AU - Anderson, Steven A.
T1 - Impact of Microbial Ecology of Meat and Poultry Products on Predictions from Exposure Assessment Scenarios for Refrigerated Storage.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2003/02//
VL - 23
IS - 1
M3 - Article
SP - 215
EP - 228
PB - Wiley-Blackwell
SN - 02724332
AB - A novel extension of traditional growth models for exposure assessment of food-borne microbial pathogens was developed to address the complex interactions of competing microbial populations in foods. Scenarios were designed for baseline refrigeration and mild abuse of servings of chicken broiler and ground beef, Our approach employed high-quality data for microbiology of foods at production, refrigerated storage temperatures, and growth kinetics of microbial populations in culture media. Simple parallel models were developed for exponential growth of multiple pathogens and the abundant and ubiquitous nonpathogenic indigenous microbiota. Monte Carlo simulations were run for unconstrained growth and growth with the density-dependent constraint based on the ‘Jameson effect,’ inhibition of pathogen growth when the indigenous microbiota reached 109 counts per serving. The modes for unconstrained growth of the indigenous microbiota were 108, 1010, and 1011 counts per serving for chicken broilers, and 107, 109, and 1011 counts per serving for ground beef at respective sites for backroom, meat case, and home refrigeration. Contamination rates and likelihoods of reaching temperatures supporting growth of the pathogens in the baseline refrigeration scenario were rare events. The unconstrained exponential growth models appeared to overestimate L. monocytogenes growth maxima for the baseline refrigeration scenario by 1500–7233% (106–107 counts/serving) when the inhibitory effects of the indigenous microbiota are ignored. The extreme tails of the distributions for the constrained models appeared to over-estimate growth maxima 110% (104–105 counts/serving) for Salmonella spp. and 108% (6 ⊗ 10³ counts/serving) for E. coli O157:H7 relative to the extremes of the unconstrained, models. The approach of incorporating parallel models for pathogens and the indigenous microbiota into exposure assessment modeling motivates the design of validation studies to test the modeling assumptions, consistent with the analytical-deliberative process of risk analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic microorganisms
KW - Pathogenic bacteria
KW - Microorganisms
KW - Microbiology
KW - Culture media (Biology)
KW - Artificial seawater
KW - Monte Carlo method
KW - Escherichia coli O157:H7
KW - food safety
KW - Growth kinetics
KW - Listeria
KW - Salmonella
N1 - Accession Number: 17490608; Coleman, Margaret E. 1; Email Address: Peg.coleman@fsis.usda.gov; Sandberg, Sonja 1,2; Anderson, Steven A. 1,2; Affiliations: 1: USDA Food Safety & Inspection Service, Office of Public Health & Science, Risk Assessment Division, Washington, DC 20250-3700; 2: Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852-1448; Issue Info: Feb2003, Vol. 23 Issue 1, p215; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Pathogenic bacteria; Thesaurus Term: Microorganisms; Thesaurus Term: Microbiology; Subject Term: Culture media (Biology); Subject Term: Artificial seawater; Subject Term: Monte Carlo method; Author-Supplied Keyword: Escherichia coli O157:H7; Author-Supplied Keyword: food safety; Author-Supplied Keyword: Growth kinetics; Author-Supplied Keyword: Listeria; Author-Supplied Keyword: Salmonella; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106815368
T1 - Clinical research: it's rewarding work.
AU - Thomas GT Sr.
A2 - Hurley ML
Y1 - 2003/02//
N1 - Accession Number: 106815368. Language: English. Entry Date: 20050507. Revision Date: 20150820. Publication Type: Journal Article; pictorial; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 20010080R.
KW - Careers in Nursing
KW - Clinical Research
KW - Nurse Researchers
KW - Consent (Research)
KW - Documentation
KW - Hospitals, Veterans
KW - Information Resources
KW - Nursing Role
KW - Persian Gulf Syndrome
KW - Research Subject Recruitment
SP - 42
EP - 45
JO - RN
JF - RN
JA - RN
VL - 66
IS - 2
CY - North Olmsted, Ohio
PB - Advanstar Communications Inc.
AB - Working as a study coordinator in clinical research is satisfying work. So says a nurse who served as one for a study of Gulf War veterans. Perhaps you'd find it enjoyable, too.
SN - 0033-7021
AD - Compliance Officer, Food and Drug Administration, College Park, MD
U2 - PMID: 12640768.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yang, H.-M.
AU - Butterworth, L.
AU - Munson, A. E.
AU - Meade, B. Jean
T1 - Respiratory Exposure to Diesel Exhaust Particles Decreases the Spleen IgM Response to a T Cell-Dependent Antigen in Female B6C3F1 Mice.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/02//
VL - 71
IS - 2
M3 - Article
SP - 207
EP - 216
PB - Oxford University Press / USA
SN - 10966080
AB - We investigated the systemic immunotoxic potential of respiratory exposure to diesel exhaust particles (DEP) in this study. Female B6C3F1 mice (∼8 weeks old) were exposed to increasing concentrations of DEP intratracheally, 3 times every two weeks, and sacrificed 2 or 4 weeks after the first exposure. The systemic toxicity and immune status in mice were evaluated. Mice exposed to DEP (1 to 15 mg/kg) showed no significant changes in body, spleen, or liver weights. Lung weights were increased in the mice exposed to 15 mg/kg DEP for 2 or 4 weeks. Except for a decreased platelet count, no significant alterations occurred in hematological parameters following DEP exposure. The number of splenic anti-sheep red blood cell (sRBC) IgM antibody-forming cells (AFC) decreased following DEP exposure for 2 weeks. This effect was less severe following 4 weeks of exposure and was only evident in the high dose group. Exposure to DEP also resulted in a significant decrease in the absolute numbers and the percentages of total spleen cells for total, CD4+, and CD8+ T cells, while the numbers of B cells and total nucleated cells in spleen were not significantly changed. The proliferative response of splenocytes to the T-cell mitogen, concanavalin A (ConA), as well as their production of IL-2 and IFN-γ, was decreased dose-dependently following exposure of mice to DEP for 2 weeks, whereas proliferation was not changed in response to anti-CD3 monoclonal antibody. In summary, short-term respiratory exposure of mice to DEP resulted in systemic immunosuppression with evidence of T cell-mediated and possibly macrophage-mediated mechanisms. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel motor exhaust gas -- Physiological aspects
KW - Immunotoxicology
KW - Immunoglobulin M
KW - T cells
KW - Immune response -- Regulation
KW - Mice as laboratory animals
KW - antibody-forming cell response
KW - cytokine modulation
KW - diesel exhaust particles
KW - immunosuppression
KW - respiratory exposure
N1 - Accession Number: 44406474; Yang, H.-M. 1; Butterworth, L. 1; Munson, A. E. 1; Meade, B. Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Issue Info: Feb2003, Vol. 71 Issue 2, p207; Subject Term: Diesel motor exhaust gas -- Physiological aspects; Subject Term: Immunotoxicology; Subject Term: Immunoglobulin M; Subject Term: T cells; Subject Term: Immune response -- Regulation; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: antibody-forming cell response; Author-Supplied Keyword: cytokine modulation; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: immunosuppression; Author-Supplied Keyword: respiratory exposure; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44406474&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chang, Gwong-Jen J.
AU - Hunt, Ann R.
AU - Holmes, Derek A.
AU - Springfield, Tracy
AU - Chiueh, Tzong-Shi
AU - Roehrig, John T.
AU - Gubler, Duane J.
T1 - Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and japanese encephalitis virus
JO - Virology
JF - Virology
Y1 - 2003/02//
VL - 306
IS - 1
M3 - Article
SP - 170
SN - 00426822
AB - We have constructed a series of plasmids encoding premembrane (prM) and envelope (E) protein genes of dengue virus type 2 (DEN-2). These plasmids included an authentic DEN-2 prM-E construct (pCBD2-14-6), and two chimeric constructs, 90% DEN-2 E-10% Japanese encephalitis (JE) virus E (pCB9D2-1J-4-3) and 80% DEN-2 E-20% JE E (pCB8D2-2J-2-9-1). Monoclonal antibody (MAb) reactivity indicated that all three plasmids expressed authentic DEN-2 virus E protein epitopes representative of flavivirus domains 1, 2, and 3. However, only the pCB8D2-2J-2-9-1 construct secreted high levels of prM, M (membrane), and E proteins into the culture fluid of plasmid-transformed COS-1 cells. The major portion of the prM and E proteins expressed by COS-1 cells transformed by pCBD2-14-6 or pCB9D2-4-3 plasmids remained membrane-bound. The results supported the notion that an unidentified membrane retention sequence is located between E-397 and E-436 of DEN-2 virus E protein. Replacing the carboxyl-terminal 20% of DEN-2 E (397-450) with the corresponding JE sequence had no effect on anti-DEN-2 MAb reactivity, indicating that this region is antigenically inert, although it is required for antigen secretion. Plasmid pCBD2-2J-2-9-1, which expressed secreted forms of prM/M and E that have the potential to form subviral particles, was superior to other constructs in stimulating an antibody response. Ninety percent neutralization titers ranging from 1:40 to >1:1000 were observed in seven of nine serum specimens from pCB8D2-2J-2-9-1-immunized mice. Eleven of twelve 2-day-old neonatal mice, derived from a pCB8D2-2J-2-9-1 immunized female mouse, survived intraperitoneal challenge of DEN-2 New Guinea C virus. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - IMMUNOGLOBULINS
KW - Chimeric plasmid
KW - Dengue virus type 2
KW - Japanese encephalitis virus
KW - Neutralizing antibody
KW - Premembrane and envelope proteins
N1 - Accession Number: 9194401; Chang, Gwong-Jen J. 1; Email Address: gxc7@cdc.gov Hunt, Ann R. 1 Holmes, Derek A. 1 Springfield, Tracy 1 Chiueh, Tzong-Shi Roehrig, John T. 1 Gubler, Duane J. 1; Affiliation: 1: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA; Source Info: Feb2003, Vol. 306 Issue 1, p170; Subject Term: DENGUE viruses; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: Chimeric plasmid; Author-Supplied Keyword: Dengue virus type 2; Author-Supplied Keyword: Japanese encephalitis virus; Author-Supplied Keyword: Neutralizing antibody; Author-Supplied Keyword: Premembrane and envelope proteins; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0042-6822(02)00028-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9194401&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vallejo, Alejandro
AU - Gurtler, Lutz
AU - Zekeng, Leopold
AU - Hewlett, Indira K.
T1 - Nucleotide sequence analysis of the accessory genes of HIV-1 group O isolates
JO - Virus Research
JF - Virus Research
Y1 - 2003/02//
VL - 91
IS - 2
M3 - Article
SP - 189
SN - 01681702
AB - Human immunodeficiency virus type 1 group O strains have been described as highly divergent, compared with the majority of the viruses classified in group M. To study the diversity and genetic characteristics of group O, we have sequenced the accessory genes of 7 isolates. Analysis of the deduced amino acid sequences for Vif, Vpr, Tat, Vpu, and Rev indicate that most of the functional domains of these proteins, as described for group M viruses, are highly conserved and retained among all the group O strains we have characterized. The only difference concerns the Vif phosphorylation sites, which are absent in all of the group O isolated we have sequence with the exception of two isolates in which only one phosphorylation site was conserved. These sites, present in nearly all of the group M isolates, play a critical role in the regulation of viral replication and infectivity. As described for group M isolates, the vpu gene is the one with the highest diversity among group O viruses. Phylogenetic analysis of these sequences suggests that group O viruses could be differentiated into at least four different clusters. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDE sequence
KW - HIV (Viruses)
KW - Accessory genes
KW - HIV-1 group O
KW - Phylogenetic analysis
KW - Sequencing
N1 - Accession Number: 9010819; Vallejo, Alejandro 1; Email Address: avallejo@cica.es Gurtler, Lutz 2 Zekeng, Leopold 3 Hewlett, Indira K. 1; Affiliation: 1: Laboratory of Molecular Virology, Food and Drug Administration, Bethesda, MD, USA 2: Institute of Microbiologic Medicine, University of Greifswald, Greifswald, Germany 3: Health Minister, Yaounde, Cameroon; Source Info: Feb2003, Vol. 91 Issue 2, p189; Subject Term: NUCLEOTIDE sequence; Subject Term: HIV (Viruses); Author-Supplied Keyword: Accessory genes; Author-Supplied Keyword: HIV-1 group O; Author-Supplied Keyword: Phylogenetic analysis; Author-Supplied Keyword: Sequencing; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9010819&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-17016-008
AN - 2004-17016-008
AU - Flint, Melanie S.
AU - Morgan, Jeremy B.
AU - Shreve, Stacey N.
AU - Tinkle, Sally S.
T1 - Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNA.
JF - Stress: The International Journal on the Biology of Stress
JO - Stress: The International Journal on the Biology of Stress
JA - Stress
Y1 - 2003/02//
VL - 6
IS - 1
SP - 59
EP - 62
CY - United Kingdom
PB - Taylor & Francis
SN - 1025-3890
SN - 1607-8888
AD - Tinkle, Sally S., Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road Mailstop 3014, Morgantown, WV, US, 26505
N1 - Accession Number: 2004-17016-008. PMID: 12637208 Partial author list: First Author & Affiliation: Flint, Melanie S.; Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Other Publishers: Informa Healthcare. Release Date: 20040913. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Corticotropin Releasing Factor; Hypothalamic Pituitary Adrenal Axis; Immunology; Skin (Anatomy); Stress. Minor Descriptor: Central Nervous System; Dermatitis; Rats. Classification: Psychophysiology (2560). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Feb, 2003.
AB - The skin is a unique immunological defense barrier that protects the organism from occupational and environmental exposures and provides a model system in which to evaluate the interaction of the central nervous system with the peripheral immune response. In the studies presented here, we tested mild, acute restraint stress activation of the cutaneous corticotropin releasing hormone-pro-opiomelanocortin (CRH-POMC) axis. We verified that 2h restraint stress increased the serum concentration of corticosterone and α-melanocyte stimulating hormone. We report for the first time that CRH upregulates POMC mRNA expression in mouse skin in vitro. We also demonstrated, by RT-PCR, that 2,4 di-nitrofluorobenzene (DNFB) upregulates cutaneous POMC mRNA expression, the production of which is suppressed by restraint stress. These data confirm the presence and functionality of two hormones of the hypothalamo-pituitary axis in the skin and suggest that activation of the central hypothalamo-pituitary-adrenal axis may over ride activation of the cutaneous CRH-POMC mechanism in the development of DNFB-stimulated allergic contact dermatitis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - restraint stress
KW - corticotrophin releasing hormone pro-opiomelanocortin
KW - mouse
KW - skin
KW - central nervous system
KW - POMC
KW - HPA axis
KW - 2003
KW - Corticotropin Releasing Factor
KW - Hypothalamic Pituitary Adrenal Axis
KW - Immunology
KW - Skin (Anatomy)
KW - Stress
KW - Central Nervous System
KW - Dermatitis
KW - Rats
KW - 2003
DO - 10.1080/1025389031000088426
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17016-008&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0001-5311-3023
UR - sft3@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-04496-006
AN - 2003-04496-006
AU - Han, Beth
AU - Wells, Barbara L.
AU - Primas, Marion
T1 - Comparison of Mammography Use by Older Black and White Women.
JF - Journal of the American Geriatrics Society
JO - Journal of the American Geriatrics Society
JA - J Am Geriatr Soc
Y1 - 2003/02//
VL - 51
IS - 2
SP - 203
EP - 212
CY - United Kingdom
PB - Blackwell Publishing
SN - 0002-8614
SN - 1532-5415
AD - Han, Beth, 4949 Battery Lane #215, Bethesda, MD, US, 20814
N1 - Accession Number: 2003-04496-006. PMID: 12558717 Partial author list: First Author & Affiliation: Han, Beth; Division of Programs for Special Populations, Bureau of Primary Health Care, Health Resources and Services Administration, U.S. Department of Health and Human Services, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Neoplasms; Gerontology; Human Females; Mammography; Racial and Ethnic Differences. Minor Descriptor: Blacks; Patient History; Whites. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Feb, 2003.
AB - Aimed to identify differences in the prevalence of ever having had a mammogram and having had a recent mammogram between older Black and White women. Another goal was to compare factors associated with mammography use in older Black and White women. Data were obtained from 499 Black and 3,328 White older women who participated in the 1998 National Health Interview Survey. Results showed that older Blacks were less likely to have ever had a mammogram than were older Whites, but there was no difference in having had a recent mammogram between older Blacks and Whites. After adjusting for other related factors, race was not related to mammography use in older Blacks and Whites. Health insurance was related to mammography use in older Whites but not in older Blacks. Even though race, per se, was not associated with mammography use in older Black and White women, many barriers to mammography use existed between older Black and White women. To promote mammography use in older Black and White women, barriers need to be specifically targeted for each group to enhance the effectiveness of breast cancer screening programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breast cancer screening
KW - health insurance
KW - mammography use
KW - patient history
KW - older Black women
KW - older White women
KW - recent mammograms
KW - 2003
KW - Breast Neoplasms
KW - Gerontology
KW - Human Females
KW - Mammography
KW - Racial and Ethnic Differences
KW - Blacks
KW - Patient History
KW - Whites
KW - 2003
DO - 10.1046/j.1532-5415.2003.51059.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-04496-006&site=ehost-live&scope=site
UR - hui_han@hotmail.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-01374-005
AN - 2003-01374-005
AU - Roberts, Charles
AU - MacNeill Horton, Arthur Jr.
T1 - Trail Making Test cut-offs for malingering among cocaine, heroin, and alcohol abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2003/02//
VL - 113
IS - 2
SP - 223
EP - 231
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - MacNeill Horton, Arthur Jr., Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockwall II Building, Suite 840, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2003-01374-005. PMID: 12751433 Partial author list: First Author & Affiliation: Roberts, Charles; Substance Abuse & Mental Health Services Administration, Ctr for Substance Abuse Treatment, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20030210. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Drug Abuse; Drug Rehabilitation; Malingering; Neuropsychological Assessment. Minor Descriptor: Alcohols; Cocaine; Cutting Scores; Heroin. Classification: Neuropsychological Assessment (2225); Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2003.
AB - The Trail Making Test (TMT) is frequently used to screen for cognitive impairments in substance abusers; however, an existing problem is that substance abusers may give poor effort and the TMT results may not be valid. In this study, cutting scores for malingering were developed from 3 samples drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS), a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 drug abuse treatment programs in 11 cities in the United States. The DATOS enrolled 7689 substance abusers (mean age 32.6 yrs) . The 3 drawn samples were for subjects with primary drugs of abuse. Number of subjects were as follows: alcohol-1000, cocaine/crack-4306, heroin-1548. Data were analyzed to determine number of substance abusers that fell beyond the upper end of the distribution of TMT scores at the 10, 5, and 1 percentiles. These percentiles were set for alcoholics, cocaine abusers, and heroin abusers. The proper use of the cut-off scores is to alert clinicians to the increasingly higher probability of poor effort when a substance abuser in 1 of the 3 groups scores beyond the one percent cut-off or his or her sample of primary drug of abuse. Clearly, the use of these cut-offs needs further empirical validation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse
KW - alcohol
KW - cocaine
KW - heroin
KW - malingering
KW - Trail Making Test
KW - cognitive impairment
KW - cutting scores
KW - 2003
KW - Cognitive Ability
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Malingering
KW - Neuropsychological Assessment
KW - Alcohols
KW - Cocaine
KW - Cutting Scores
KW - Heroin
KW - 2003
DO - 10.1080/00207450390162047
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-01374-005&site=ehost-live&scope=site
UR - ahorton@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-01609-001
AN - 2003-01609-001
AU - Racoosin, Judith A.
T1 - Mortality in epilepsy: Searching for clues in populations and patients.
JF - Neurology
JO - Neurology
Y1 - 2003/02//
VL - 60
IS - 3
SP - 363
EP - 364
CY - US
PB - Lippincott Williams & Wilkins
SN - 0028-3878
SN - 1526-632X
AD - Racoosin, Judith A., Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, US, 20857
N1 - Accession Number: 2003-01609-001. PMID: 12578914 Partial author list: First Author & Affiliation: Racoosin, Judith A.; Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, US. Release Date: 20031201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Epilepsy; Epileptic Seizures; Mortality Rate. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Feb, 2003.
AB - Editorial discusses two groups using complementary methods that report findings relevant to mortality in epilepsy in this issue. 'Remote symptomatic epilepsy:Does seizure severity increase mortality?' by Strauss et al. used a population-based approach while 'Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients' by Tigaran et al. used a patient-based approach. Standardized mortality ratios (SMR) and excess death rates (EDR) stratified by frequency of seizures was presented in the first study. Notably, the SMR/EDR of patients who had a history of epilepsy but did not have a seizure in the prior year did not differ significantly from those who never had a history of epilepsy. The second study performed extensive cardiovascular examinations on a small cohort of individuals with refractory epilepsy. This latter group's goal was to identify a mechanism for sudden unexplained death in epilepsy (SUDEP) in this high-risk population. It was found that 40% of patients had sustained ST depression during or just after a seizure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - standardized mortality ratios
KW - refractory epilepsy
KW - seizure frequency
KW - mortality rate
KW - death rates
KW - epilepsy
KW - 2003
KW - Epilepsy
KW - Epileptic Seizures
KW - Mortality Rate
KW - 2003
DO - 10.1212/WNL.60.3.363
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-01609-001&site=ehost-live&scope=site
UR - racoosinj@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Narva, Andrew S.
T1 - The spectrum of kidney disease in American Indians.
JO - Kidney International
JF - Kidney International
Y1 - 2003/02/02/Feb2003 Supplement 83
VL - 63
M3 - Article
SP - S3
EP - S7
SN - 00852538
AB - The spectrum of kidney disease in American Indians. American Indians and Alaska Natives (AI/AN) experience high rates of chronic kidney disease. Several studies have demonstrated increased rates of early kidney disease among AI/AN, both in diabetics and non-diabetics. Among some tribes of the American Southwest, high rates of mesangiopathic glomerulonephritis have been documented. The epidemic of diabetes among AI/AN, which began in the middle of the 20th century, appears to be driving the increase in end-stage renal disease (ESRD). At the end of 1999, AI/AN had a national prevalence rate of treated ESRD that was 3.5 times greater than that of white Americans. There is significant regional variation as well as differences among the approximately 550 tribes that make up the American Indian community, with some tribes experiencing ESRD rates over twenty times the rate of whites. Although graft survival is excellent, AI/AN ESRD patients are less likely than whites to be placed on the transplant waiting list, and those listed wait longer for a transplant. Despite socioeconomic barriers and high rates of co-morbid illness, survival among AI/AN ESRD patients is better than among whites. The burden of kidney disease, particularly the multigenerational occurrence in some families, is perceived as a major threat to the well-being of native communities. There is a sense of urgency among tribal leaders to address this epidemic, and research that may decrease its burden is likely to be welcomed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDIGENOUS peoples of the Americas
KW - MEDICAL care
KW - KIDNEY diseases -- Treatment
KW - KIDNEY failure
KW - CHRONIC kidney failure
KW - MINORITIES -- Medical care
KW - GENETIC aspects
KW - TREATMENT
KW - chronic renal disease
KW - kidney diseases
KW - kidney failure
KW - Native Americans
KW - renal transplantation
N1 - Accession Number: 118849611; Narva, Andrew S. 1; Email Address: anarva@abq.ihs.gov; Affiliation: 1: Indian Health Service Kidney Disease Program, Albuquerque, New Mexico, USA 1; Source Info: Feb2003 Supplement 83, Vol. 63, pS3; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: MEDICAL care; Subject Term: KIDNEY diseases -- Treatment; Subject Term: KIDNEY failure; Subject Term: CHRONIC kidney failure; Subject Term: MINORITIES -- Medical care; Subject Term: GENETIC aspects; Subject Term: TREATMENT; Author-Supplied Keyword: chronic renal disease; Author-Supplied Keyword: kidney diseases; Author-Supplied Keyword: kidney failure; Author-Supplied Keyword: Native Americans; Author-Supplied Keyword: renal transplantation; Number of Pages: 1p; Document Type: Article
L3 - 10.1046/j.1523-1755.63.s83.2.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=118849611&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106885360
T1 - Mortality in epilepsy: searching for clues in populations and patients.
AU - Racoosin JA
Y1 - 2003/02/11/2003 Feb 11
N1 - Accession Number: 106885360. Language: English. Entry Date: 20031114. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: Strauss DJ, Day SM, Shavelle RM, Wu YW. Remote symptomatic epilepsy: does seizure severity increase mortality? (NEUROLOGY) 2003 Feb 11; 60 (3): 395-399; Tigaran S, Mølgaard H, McClelland R, Dam M, Jaffe AS. Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients. (NEUROLOGY) 2003 Feb 11; 60 (3): 492-495. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0401060.
KW - Epilepsy -- Mortality
SP - 363
EP - 364
JO - Neurology
JF - Neurology
JA - NEUROLOGY
VL - 60
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0028-3878
AD - Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD; racoosinj@cder.fda.gov
U2 - PMID: 12578914.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106885360&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106885383
T1 - Sex differences in carotid endarterectomy utilization and 30-day postoperative mortality.
AU - Sheikh K
AU - Bullock C
Y1 - 2003/02/11/2003 Feb 11
N1 - Accession Number: 106885383. Language: English. Entry Date: 20031114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0401060.
KW - Endarterectomy, Carotid -- Mortality -- United States
KW - Endarterectomy, Carotid -- Utilization -- United States
KW - Age Factors
KW - Aged
KW - Chi Square Test
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Geographic Factors
KW - Male
KW - Retrospective Design
KW - Sex Factors
KW - United States
KW - Human
SP - 471
EP - 476
JO - Neurology
JF - Neurology
JA - NEUROLOGY
VL - 60
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: To study trends, and sex and regional differences in utilization of the carotid endarterectomy (CEA) procedure and 30-day postoperative mortality from 1991 to 1999. METHODS: Retrospective analysis of fee-for-service claims and mortality data for Medicare beneficiaries aged 65 years and older in the United States. RESULTS: The male and female CEA rates and 30-day mortality increased with age up to the age of 79 years. From 1991 to 1995, the age-adjusted male and female CEA rates increased 72% from 26.6 and 14.2 procedures per 10,000 beneficiaries. Thereafter, the CEA rates slightly decreased except for the 80 years and older age group, which increased through 1999. In each year from 1991 to 1999, the age-adjusted male CEA rates were approximately 1.9 times higher than the corresponding female rates. From 1991 to 1998, the age-adjusted male and female 30-day mortality decreased 29.3% and 46.4% from 19.2 and 18.1 deaths per 1,000 procedures. From 1992 to 1997, except 1994, 30-day mortality was higher in men than in women. This sex difference was not present in the 65 to 69 years age group. There were small differences in CEA rates between two of the four regions of the United States in 3 of the 9 years. CONCLUSIONS: Increasing CEA rates with decreasing postoperative mortality suggest that CEA may have been more frequently performed on low-risk patients. The apparent sex differences in CEA rates may not be true differences.
SN - 0028-3878
AD - US Department of Health and Human Services, Center for Medicare & Medicaid Services, Kansas City, MO; ksheikh@cms.hhs.gov
U2 - PMID: 12578929.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106885383&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shvartsburg, Alexandre A.
AU - Wilkes, Jon G.
T1 - Chemistry in aldol complexes of metal dications: dehydration of the bisligand species
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
Y1 - 2003/02/15/
VL - 225
IS - 2
M3 - Article
SP - 155
SN - 13873806
AB - The advent of electrospray has enabled the generation of microsolvated multiply charged metal ions. For dications, these had been produced for most common organic ligand classes including simple alcohols and ketones, but not aldols. Solution-phase aldol chemistry is reknown for dehydration and retro-aldol reactions. One of the simplest aldols is the acetone dimer, known as diacetone alcohol (DAA). It has recently been shown to coordinate gas-phase metal trications—the first precedent thereof for any protic solvent. Here we report on the formation and collisional fragmentation of DAA complexes for dications of divalent metals (M=Mg , Ca, Ba, Mn, Ni, Co, Fe, and Cu). Both retro-aldol and dehydration processes were observed in these species. Most notable is the extreme size-specificity of dehydration. Sequential loss of two waters dominates the dissociation of M2+(DAA)2 for all metals studied, yielding extraordinary M2+(mesityl oxide)2 peaks. However, M2+(DAA)3 essentially do not dehydrate. This suggests a geometry of complexes with two DAA in the first solvation shell, perhaps in a bidentate arrangement involving both carbonyl and hydroxyl. Similarly to their simple alcohol analogs, charge-reduction of M2+(DAA)n proceeds via proton transfer, except in the case of Cu where proton and electron transfers compete. A comparison of the critical and minimum sizes for M2+(DAA)n and M3+(DAA)n reveals a major intrinsic gap between the stabilities of metal di- and trications in protic solvent complexes. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Mass Spectrometry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIPLY charged ions
KW - METAL catalysts
KW - Dehydration
KW - Electrospray ionization
KW - Ion solvation
KW - Metal cations
KW - Multiply charged ions
N1 - Accession Number: 8930062; Shvartsburg, Alexandre A.; Email Address: ashvartsburg@nctr.fda.gov Wilkes, Jon G. 1; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, HFT-233, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Feb2003, Vol. 225 Issue 2, p155; Subject Term: MULTIPLY charged ions; Subject Term: METAL catalysts; Author-Supplied Keyword: Dehydration; Author-Supplied Keyword: Electrospray ionization; Author-Supplied Keyword: Ion solvation; Author-Supplied Keyword: Metal cations; Author-Supplied Keyword: Multiply charged ions; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S1387-3806(02)01112-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Dae Joong
AU - Shin, Dong Hwan
AU - Ahn, Byeongwoo
AU - Kang, Jin Seok
AU - Nam, Ki Taek
AU - Park, Cheol Beom
AU - Kim, Cheul Kyu
AU - Hong, Jin Tae
AU - Kim, Yun-Bae
AU - Yun, Young Won
AU - Jang, Dong Deuk
AU - Yang, Ki-Hwa
T1 - Chemoprevention of colon cancer by Korean food plant components
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/02/20/
VL - 523/524
M3 - Article
SP - 99
SN - 00275107
AB - Inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS/NOS-2) play pivotal roles as mediators of inflammation involved in early steps of carcinogenesis in certain organs. Therefore, chemoprevention is theoretically possible through inhibition of COX-2 and/or iNOS. In the present study, we examined the chemopreventive effects of indole-3-carbinol (I3C), a constituent of cruciferous vegetables (the family of Cruciferae) such as cabbages, cauliflowers and broccoli on the multiple intestinal neoplasia (Min) genetic mouse model, and on mouse colon carcinogenesis induced by azoxymethane (AOM). The consumption of cruciferous vegetables such as cabbage, broccoli, and Brussels sprouts has been shown to have cancer chemopreventive effects in humans and experimental animals. I3C has been shown to exert a cancer chemopreventive influence in liver, colon, and mammary tissue when given before or concurrent with exposure to a carcinogen.Powdered AIN-76A diets (Harlan Teklad Research Diet, Madison, USA) containing 100 or 300 ppm I3C (group 1 or 2) or the same pellet diets without supplement (group 3) were fed to 6-week-old male C57BL/6J-ApcMin/+ (Min/+) mice (The Jackson Laboratory, Bar Harbor, ME, USA) for 10 weeks. In addition the same diets were given to wild-type normal C57BL/6J-ApcMin/+ littermates after AOM initiation (groups 4–7: 10 mice in each group) for 32 weeks from week 4. At 16 weeks of age, all Min/+ mice (groups 1–3) were sacrificed for assessment of intestinal polyp development. The incidences of the colonic adenomatous polyps in the groups 1–3 were 60% (12/20), 60% (15/25) and 84% (21/25), respectively. A decreasing tendency in multiplicities of the colonic adenomatous polyps in group 1 (I3C 100 ppm; 0.85±0.22 ; 61%) and group 2 (I3C 300 ppm; 1.32±0.28 ; 94%) was observed when compared with group 3 (control; 1.40±0.21 ; 100%). Total number of aberrant crypt foci (ACF)/colon or aberrant crypts (AC)/colon in wild-type mice of group 4 or 5 were decreased significantly compared with those of the AOM alone group (group 6) (P<0.01 ). These results suggest that I3C may be a potential chemopreventive agent for colon cancer. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer
KW - NITRIC oxide
KW - CANCER -- Chemoprevention
KW - Aberrant crypt foci (ACF)
KW - Aberrant crypts (AC)
KW - Adenomatous polyposis coli (APC) gene
KW - Azoxymethane (AOM)
KW - C57BL/6J-ApcMin/+ mice (Min/+ mice)
KW - Chemoprevention
KW - Colon cancer
KW - Familial adenomatous polyposis (FAP)
KW - Indole-3-carbinol (I3C)
KW - Inducible cyclooxygenase (COX-2)
KW - Inducible nitric oxide synthase (iNOS/NOS-2)
KW - Multiple intestinal neoplasia (Min)
N1 - Accession Number: 9282264; Kim, Dae Joong 1; Email Address: kimdj@cbu.ac.kr Shin, Dong Hwan 2 Ahn, Byeongwoo 2 Kang, Jin Seok 2 Nam, Ki Taek 2 Park, Cheol Beom 1 Kim, Cheul Kyu 2 Hong, Jin Tae 3 Kim, Yun-Bae 1 Yun, Young Won 1 Jang, Dong Deuk 2 Yang, Ki-Hwa 2; Affiliation: 1: Structural BioInformatics & Cancer Prevention, College of Veterinary Medicine & Research Institute of Veterinary Medicine, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju 361-763, South Korea 2: Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administration, Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea 3: College of Pharmacy, Chungbuk National University, 48 Gaeshin-dong, Heungduk-gu, Cheongju 361-763, South Korea; Source Info: Feb/Mar2003, Vol. 523/524, p99; Subject Term: COLON cancer; Subject Term: NITRIC oxide; Subject Term: CANCER -- Chemoprevention; Author-Supplied Keyword: Aberrant crypt foci (ACF); Author-Supplied Keyword: Aberrant crypts (AC); Author-Supplied Keyword: Adenomatous polyposis coli (APC) gene; Author-Supplied Keyword: Azoxymethane (AOM); Author-Supplied Keyword: C57BL/6J-ApcMin/+ mice (Min/+ mice); Author-Supplied Keyword: Chemoprevention; Author-Supplied Keyword: Colon cancer; Author-Supplied Keyword: Familial adenomatous polyposis (FAP); Author-Supplied Keyword: Indole-3-carbinol (I3C); Author-Supplied Keyword: Inducible cyclooxygenase (COX-2); Author-Supplied Keyword: Inducible nitric oxide synthase (iNOS/NOS-2); Author-Supplied Keyword: Multiple intestinal neoplasia (Min); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0027-5107(02)00325-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, Dong-Xin
AU - Thompson, Patricia A.
AU - Teitel, Candee
AU - Chen, Jun-Shi
AU - Kadlubar, Fred F.
T1 - Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP–DNA adduct formation
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/02/20/
VL - 523/524
M3 - Article
SP - 193
SN - 00275107
AB - The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)–DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% (w/v)) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body weight) by oral gavage. PhIP–DNA adducts in the liver, colon, heart, and lung were measured using the 32P -postlabelling technique. Rats pre-treated with tea and given PhIP 20 h before sacrifice had significantly reduced levels of PhIP–DNA adducts as compared with controls given PhIP alone. The possible mechanism of protective effect of tea on PhIP–DNA adduct formation was then examined in vitro. It was found that an aqueous extract of green and black tea, mixtures of green and black tea polyphenols, as well as purified polyphenols could strongly inhibit the DNA binding of N-acetoxy-PhIP, a putative ultimate carcinogen of PhIP formed in vivo via metabolic activation. Among these, epigallocatechin gallate was exceptionally potent. HPLC analyses of these incubation mixtures containing N-acetoxy-PhIP and the tea polyphenols each revealed the production of the parent amine, PhIP, indicating the involvement of a redox mechanism. In view of the presence of relatively high levels of tea polyphenols in rat and human plasma after ingestion of tea, this study suggests that direct reduction of the ultimate carcinogen N-acetoxy-PhIP by tea polyphenols is likely to be involved in the mechanism of chemoprotection of tea against this carcinogen. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEA
KW - CHEMOPREVENTION
KW - POLYPHENOLS
KW - Chemoprevention
KW - Foodborne carcinogens
KW - Heterocyclic amines
KW - Tea polyphenols
N1 - Accession Number: 9282204; Lin, Dong-Xin 1,2 Thompson, Patricia A. 2 Teitel, Candee 2 Chen, Jun-Shi 3 Kadlubar, Fred F. 2; Email Address: fkadlubar@nctr.fda.gov; Affiliation: 1: Division of Cancer Etiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing Union Medical University, Beijing 100021, China 2: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China; Source Info: Feb/Mar2003, Vol. 523/524, p193; Subject Term: TEA; Subject Term: CHEMOPREVENTION; Subject Term: POLYPHENOLS; Author-Supplied Keyword: Chemoprevention; Author-Supplied Keyword: Foodborne carcinogens; Author-Supplied Keyword: Heterocyclic amines; Author-Supplied Keyword: Tea polyphenols; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 311920 Coffee and Tea Manufacturing; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0027-5107(02)00335-4
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 106838254
T1 - Improving quality and reducing disparities: toward a common pathway.
AU - Aaron KF
AU - Clancy CM
AU - Aaron, Kaytura Felix
AU - Clancy, Carolyn M
Y1 - 2003/02/26/
N1 - Accession Number: 106838254. Language: English. Entry Date: 20030606. Revision Date: 20161112. Publication Type: commentary; commentary; editorial. Original Study: Sehgal AR, Sehgal Ashwini R. Impact of quality improvement efforts on race and sex disparities in hemodialysis. (JAMA) 2/26/2003; 289 (8): 996-1000. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Dialysis Patients
KW - Health Services Accessibility
KW - Hemodialysis
KW - Minority Groups
KW - Quality Improvement
KW - Blacks
KW - Process Assessment (Health Care)
KW - Quality of Health Care
KW - Race Factors
KW - Sex Factors
KW - Socioeconomic Factors
KW - United States Centers for Medicare and Medicaid Services
KW - Whites
SP - 1033
EP - 1034
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 289
IS - 8
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of Priority Populations Research, Agency for Healthcare Research and Quality, 2101 E Jefferson St, Suite 600, Rockville, MD 20852; kfaaron@ahrq.gov
U2 - PMID: 12597759.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - da Silva, Alexandre J.
AU - Cacciò, Simone
AU - Williams, Cathy
AU - Won, Kimberly Y.
AU - Nace, Eva K.
AU - Whittier, Christopher
AU - Pieniazek, Norman J.
AU - Eberhard, Mark L.
T1 - Molecular and morphologic characterization of a Cryptosporidium genotype identified in lemurs
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2003/02/27/
VL - 111
IS - 4
M3 - Article
SP - 297
SN - 03044017
AB - This study reports the molecular and morphologic characterization of a Cryptosporidium sp., identified in stools of captive lemurs Propithecus verreauxi coquereli. Stool samples were collected from seven animals (n=7 ) presenting episodes of diarrhea. Bright-field light microscopy of stool smears stained with modified acid-fast technique revealed the presence of Cryptosporidium sp. oocysts in four of the stool samples analyzed. All microscopically positive samples were confirmed by PCR using primers designed to amplify DNA fragments from two independent loci, i.e. the Cryptosporidium oocyst wall protein (COWP) gene and the small subunit ribosomal RNA (ssrRNA) gene. Phylogenetic analysis based on the full-length ssrRNA gene placed this isolate within a clade that contains all currently known C. parvum species/genotypes, closely related to the C. parvum pig genotype. Comparison with partial ssrRNA sequences available in the GenBank™ revealed 100% sequence identity with the genotype previously identified in Canadian patients. This finding was confirmed further by comparison of the COWP gene partial sequences. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM
KW - POLYMERASE chain reaction
KW - Cryptosporidium sp.
KW - Lemurs
KW - Microscopy
KW - PCR
KW - Phylogenetic analysis
N1 - Accession Number: 8997640; da Silva, Alexandre J. 1; Email Address: abs8@cdc.gov Cacciò, Simone 2 Williams, Cathy 3 Won, Kimberly Y. 1 Nace, Eva K. 1 Whittier, Christopher 4 Pieniazek, Norman J. 1 Eberhard, Mark L. 1; Affiliation: 1: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30341-3724, USA 2: Laboratory of Parasitology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy 3: The Duke University Primate Center, Duke University, Durham, NC, USA 4: Environmental Medicine Consortium, Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA; Source Info: Feb2003, Vol. 111 Issue 4, p297; Subject Term: CRYPTOSPORIDIUM; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Cryptosporidium sp.; Author-Supplied Keyword: Lemurs; Author-Supplied Keyword: Microscopy; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Phylogenetic analysis; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106360983
T1 - The federal perspective: research opens new doors. Welcome to the age of buprenorphine.
AU - Curie CG
Y1 - 2003/03//2003 Mar
N1 - Accession Number: 106360983. Language: English. Entry Date: 20061117. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; USA. NLM UID: 101176508.
KW - Buprenorphine -- Therapeutic Use
KW - Physicians
KW - Substance Dependence -- Drug Therapy
KW - Medical Practice
SP - 12
EP - 15
JO - Addiction Professional
JF - Addiction Professional
JA - ADDICT PROF
VL - 1
IS - 2
CY - New York, New York
PB - Vendome Group LLC
AB - The pace of discovery in the addiction field continues to quicken. These perspectives from and about directors of the field's three leading federal agencies cover some of the new directions that will alter the course of treatment.
SN - 1542-8435
AD - Administrator, Substance Abuse and Mental Health Services Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Williams, Bruce
AU - Murray, Miranda
AU - Harris, Dale
AU - Conviser, Richard
T1 - Careproviders' Adherence to HIV Standards of Care Is Uniformly High in an Integrated HIV Care System.
JO - AIDS & Public Policy Journal
JF - AIDS & Public Policy Journal
Y1 - 2003///Spring/Summer2003
VL - 18
IS - 1/2
M3 - Article
SP - 20
EP - 34
SN - 08873852
AB - Examines careproviders' adherence to HIV standards of care in an integrated HIV care system in New Mexico. Role of clinical experience on careproviders' adherence to HIV standards of care; Primary care of HIV-positive persons; HIV healthcare planning.
KW - HIV infections
KW - AIDS (Disease)
KW - MEDICAL care
KW - HIV-positive persons
KW - STANDARDS
KW - NEW Mexico
N1 - Accession Number: 15023469; Williams, Bruce 1; Email Address: bwilliams@salud.unm.edu Murray, Miranda 2 Harris, Dale 3 Conviser, Richard 4; Affiliation: 1: Professor, Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Sciences Center 2: Consultant, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Washington, D.C. 3: HIV Quality Management Nurse, Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Sciences Center 4: Chief of the Service Evaluation and Research Branch, Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland; Source Info: Spring/Summer2003, Vol. 18 Issue 1/2, p20; Subject Term: HIV infections; Subject Term: AIDS (Disease); Subject Term: MEDICAL care; Subject Term: HIV-positive persons; Subject Term: STANDARDS; Subject Term: NEW Mexico; Number of Pages: 15p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graham, David J.
AU - Green, Lanh
AU - Senior, John R.
AU - Nourjah, Parivash
T1 - Troglitazone-induced liver failure: a case study
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 2003/03//
VL - 114
IS - 4
M3 - Article
SP - 299
SN - 00029343
AB - : BackgroundTroglitazone was removed from the U.S. market because its use was associated with an increased risk of liver failure. We evaluated the clinical features of all cases reported to the Food and Drug Administration and estimated the duration and magnitude of the risk of liver failure associated with continued use of the drug.: MethodsData from cases of liver failure associated with troglitazone use were abstracted and analyzed. The extent of troglitazone use was determined from national marketing data, and the duration of use was estimated with data from a large, multistate, health care company. Survival analysis was performed to estimate monthly incidence rates and the cumulative risk of liver failure.: ResultsNinety-four cases of liver failure (89 acute, 5 chronic) were reported. Of the acute cases, 58 (67%) were women and only 11 (13%) recovered without liver transplantation. Progression from normal hepatic functioning to irreversible liver injury occurred within 1 month in 19 patients who were indistinguishable clinically from the 70 patients who had an unknown time course to irreversibility, except for the post hoc observation that prior cholecystectomy was less common in those with rapid onset. The incidence of liver failure was elevated from the first through at least the 26th month of troglitazone use. Accounting for case underreporting, the number needed to harm from troglitazone use was between 600 to 1500 patients at 26 months.: ConclusionThe progression to irreversible liver injury probably occurred within a 1-month interval in most patients, casting doubt on the value of monthly monitoring of serum aminotransferase levels as a means of preventing troglitazone-induced acute liver failure. The cumulative risk of hepatic failure increased with continued use. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Medicine is the property of Excerpta Medica Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER failure
KW - UNITED States
N1 - Accession Number: 9446884; Graham, David J. 1; Email Address: grahamd@cder.fda.gov Green, Lanh 1 Senior, John R. 1 Nourjah, Parivash 1; Affiliation: 1: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Mar2003, Vol. 114 Issue 4, p299; Subject Term: LIVER failure; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0002-9343(02)01529-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106865505
T1 - The plain language movement.
AU - Locke J
Y1 - 2003/03//
N1 - Accession Number: 106865505. Language: English. Entry Date: 20030905. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8705793.
KW - Language
KW - Medical Literature
KW - Writing for Publication
KW - Drug Labeling
KW - Government Agencies
KW - Government Publications
KW - United States
KW - United States Food and Drug Administration
SP - 5
EP - 8
JO - AMWA Journal: American Medical Writers Association Journal
JF - AMWA Journal: American Medical Writers Association Journal
JA - AMWA J
VL - 18
IS - 1
CY - Rockville, Maryland
PB - American Medical Writers Association (AMWA)
SN - 1075-6361
AD - Senior Policy Advisor and Plain Language Coordinator, US Food and Drug Administration, Health and Human Services Dept
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MAYNARD, ANDREW D.
T1 - Estimating Aerosol Surface Area from Number and Mass Concentration Measurements.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2003/03//
VL - 47
IS - 2
M3 - Article
SP - 123
EP - 144
SN - 00034878
AB - A number of toxicology studies have been published indicating that health effects associated with low-solubility inhaled particles may be more appropriately associated with particulate surface area than mass. While exposure data from the workplace is needed to further investigate the relevance of such an association, the means of measuring exposure to aerosol surface area are not readily available. A possible interim solution is to estimate surface area from measurements of particle number and mass concentration using readily available direct-reading instruments. By assuming a lognormal aerosol size distribution with a specific geometric standard deviation, number and mass concentration measurements may be used to estimate the surface area concentration associated with the distribution. Simulations have shown that surface area estimates made on unimodal lognormal aerosols will frequently lie within 100% of the actual value. Simulations using bimodal distributions indicate estimates of surface area vary from the actual value by less than an order of magnitude. Calculations based on experimental unimodal and bimodal data confirm these findings, with estimated surface area rarely being a factor of 4 greater than the actual value, and frequently being much closer than this. These findings indicate that estimating aerosol surface area exposure using readily available number and mass concentration direct-reading instruments may be suitable for providing initial data on the magnitude of surface area exposures with minimal additional effort. This would allow the accumulation of valuable exposure–response data prior to the development and implementation of more sophisticated instrumentation to more accurately estimate surface area exposure. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Industrial toxicology
KW - Simulation methods & models
KW - Surface area
KW - Lognormal distribution
KW - Standard deviations
KW - aerosol
KW - exposure assessment
KW - mass concentration
KW - number concentration
KW - surface area
KW - ultrafine aerosol
N1 - Accession Number: 44400232; MAYNARD, ANDREW D. 1; Email Address: zel5@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: Mar2003, Vol. 47 Issue 2, p123; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Industrial toxicology; Thesaurus Term: Simulation methods & models; Subject Term: Surface area; Subject Term: Lognormal distribution; Subject Term: Standard deviations; Author-Supplied Keyword: aerosol; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: mass concentration; Author-Supplied Keyword: number concentration; Author-Supplied Keyword: surface area; Author-Supplied Keyword: ultrafine aerosol; Number of Pages: 22p; Illustrations: 5 Charts, 10 Graphs; Document Type: Article
L3 - 10.1093/annhyg/meg022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44400232&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Madhi, Shabir A.
AU - Radebe, Kholeka
AU - Crewe-Brown, Heather
AU - Frasch, Carl E.
AU - Arakere, Guthrie
AU - Mokhachane, Mantoa
AU - Kimura, Alan
T1 - High burden of invasive Streptococcus agalactiae disease in South African infants.
JO - Annals of Tropical Paediatrics
JF - Annals of Tropical Paediatrics
Y1 - 2003/03//
VL - 23
IS - 1
M3 - Article
SP - 15
EP - 23
PB - Taylor & Francis Ltd
SN - 02724936
AB - The epidemiology of invasive Streptococcus agalactiae (GBS) disease was evaluated in South African children. Records of 208/220 children in whom GBS was isolated between January 1997 and December 1999 were reviewed. These included 63%, 31.7% and 5.3% children with early- (EOD, <7 days of age), late- (LOD, age 7-90 days) and childhood-onset disease (COD, age >90 days), respectively. The overall burden of EOD and LOD were 2.06 and 1/1000 live births, respectively. The overall mortality was 19.8% and 13.6% for infants with EOD and LOD, respectively. Risk factors for mortality in infants with EOD and LOD included septic shock (82.1% vs 1.9%), prematurity (35.2% vs 9.6%), low birthweight (29.2% vs 11.0%) and a leucocyte count <5000/mm[sup 3] (43.5% vs 18.6%). Eight (72.7%) of 11 children with COD had an immunosuppressive, predisposing cause for invasive bacterial disease. In infants with EOD and LOD, serotype III isolates caused 49.2% and 75.7% of disease, respectively, and, together with serotype Ia isolates, caused 78.9% and 100% of invasive disease, respectively. Invasive GBS disease is common in South African infants and current strategies aimed at reducing the burden of the disease should be reconsidered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Paediatrics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STREPTOCOCCUS agalactiae
KW - STREPTOCOCCAL diseases
KW - PEDIATRICS
KW - SOUTH Africa
N1 - Accession Number: 9326458; Madhi, Shabir A. 1 Radebe, Kholeka 2 Crewe-Brown, Heather 2 Frasch, Carl E. 3 Arakere, Guthrie 3 Mokhachane, Mantoa 4 Kimura, Alan 5; Affiliation: 1: NHLS/Wits/MRC Pneumococcal Diseases Research Unit, & Paediatric Infectious Diseases Research Unit, University of the Witswaterand, Johannesburg, South Africa 2: NHLS/Wits/MRC Pneumococcal Diseases Research Unit, University of the Witswaterand, Johannesburg, South Africa 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA 4: Department of Paediatrics, University of the Witswaterand, Johannesburg, South Africa 5: Bio-Chem Pharma, Northborough, Massachusetts, USA; Source Info: Mar2003, Vol. 23 Issue 1, p15; Subject Term: STREPTOCOCCUS agalactiae; Subject Term: STREPTOCOCCAL diseases; Subject Term: PEDIATRICS; Subject Term: SOUTH Africa; Number of Pages: 9p; Document Type: Article
L3 - 10.1179/000349803125002814
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chin, Jaeho
AU - Sohn, Yeowon
AU - Lee, Seok Ho
AU - Park, Young In
AU - Choi, Myung Ja
T1 - Production of neutralizing human monoclonal antibody directed to tetanus toxin in CHO cell
JO - Biologicals
JF - Biologicals
Y1 - 2003/03//
VL - 31
IS - 1
M3 - Article
SP - 45
SN - 10451056
AB - By the fusion of lymphocytes from hyperimmunized people with heteromyeloma cells, 600 human hybridoma cell lines were generated. Even though seven cell lines produced antibodies against tetanus toxoid, only two antibodies from hybrid CH8 and CH5 only neutralized the tetanus toxin and completely protected the mice that had been challenged with the toxin even at the level of 90 mean lethal dose. The cDNA of light (L) chain and heavy (H) chain variable region was isolated, and then inserted into expression vectors containing human IgG constant regions. After transfection of the recombinant human IgG gene into Chinese Hamster Ovary (CHO) cells, transformants secreting the complete human antibody were selected. The recombinant human antibodies produced from CHO cells possessed neutralizing activity against tetanus toxin just like the original human antibodies produced from human hybridoma cell lines. Western blot analysis showed that rCH8 and rCH5 antibodies recognized the H chain of tetanus toxin and did not bind to its L chain. The neutralizing test showed that HmAb rCH5 had 4.55 IU and HmAb rCH8 had 1.09 IU/100 μg of IgG, respectively. Mixing of the two HmAbs resulted in synergistic effects. On a weight basis (IU/100 μg IgG), the highest potency values were obtained when the two HmAbs were combined in equal quantity. The neutralizing activity of rCH8 and rCH5 mixture was 6.94 IU/100 μg IgG. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL lines
KW - TETANUS
KW - Anti-tetanus monoclonal antibodies
KW - Chinese Hamster Ovary cells
KW - Protection against tetanus
KW - Recombinant human IgG
KW - Toxin-neutralization
N1 - Accession Number: 9193842; Chin, Jaeho 1,2,3 Sohn, Yeowon 3 Lee, Seok Ho 3 Park, Young In 2 Choi, Myung Ja 1; Email Address: cmj474@kist.re.kr; Affiliation: 1: Center of Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul 130-650, South Korea 2: Laboratory of Molecular Biology, Graduate School of Biotechnology, Korea University, Seoul 136-701, South Korea 3: Center of Biological Evaluation, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Mar2003, Vol. 31 Issue 1, p45; Subject Term: CELL lines; Subject Term: TETANUS; Author-Supplied Keyword: Anti-tetanus monoclonal antibodies; Author-Supplied Keyword: Chinese Hamster Ovary cells; Author-Supplied Keyword: Protection against tetanus; Author-Supplied Keyword: Recombinant human IgG; Author-Supplied Keyword: Toxin-neutralization; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S1045-1056(02)00092-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Amexis, Georgios
AU - Ridge, Jeanette
AU - Cervenakova, Larisa
AU - Enterline, Joan C.
AU - Chumakov, Konstantin M.
AU - Asher, David M.
T1 - Stability of the prion protein-encoding (PRNP) gene in HeLa cells
JO - Biologicals
JF - Biologicals
Y1 - 2003/03//
VL - 31
IS - 1
M3 - Article
SP - 83
SN - 10451056
AB - To assess the risk of the de novo emergence of the agent of transmissible spongiform encephalopathies in cultured cells, we examined the stability of the prion protein-encoding (PRNP) gene in HeLa cells and in cultures contaminated with HeLa cells that have been passaged extensively for over 50 years. Various sub-lineages of HeLa cells showed that some contained a mixture of a truncated PRNP gene (R3–R4 deletion) and a full-length PRNP gene, while others were homozygous for the R3–R4 deletion. That finding suggests that the progenitor of several popular sub-lineages of HeLa must have lost part or all of chromosome 20 early in the history of HeLa cells. No mutations were found in the PRNP genes. We conclude that the spontaneous appearance of mutations leading to expression of abnormal prion proteins in continuously passaged heteroploid cell lines is unlikely to pose a substantial risk for the safe production of biologicals in such cells. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - CHROMOSOMES
KW - Creutzfeldt–Jakob disease
KW - Gene stability
KW - HeLa cell
KW - Prion
KW - PRNP
KW - PrP protein
KW - Transmissible spongiform encephalopathies
N1 - Accession Number: 9193846; Amexis, Georgios 1 Ridge, Jeanette 1 Cervenakova, Larisa 2 Enterline, Joan C. 1 Chumakov, Konstantin M. 1 Asher, David M. 1; Email Address: asher@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, HFM-313, Rockville,MD 20852-1448, USA 2: Holland Laboratories, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA; Source Info: Mar2003, Vol. 31 Issue 1, p83; Subject Term: MUTATION (Biology); Subject Term: CHROMOSOMES; Author-Supplied Keyword: Creutzfeldt–Jakob disease; Author-Supplied Keyword: Gene stability; Author-Supplied Keyword: HeLa cell; Author-Supplied Keyword: Prion; Author-Supplied Keyword: PRNP; Author-Supplied Keyword: PrP protein; Author-Supplied Keyword: Transmissible spongiform encephalopathies; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S1045-1056(02)00069-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abrams, P.
AU - Blaivas, J.G.
AU - Fowler, C.J.
AU - Fourcroy, J.L.
AU - Macdiarmid, S.A.
AU - Siegel, S.W.
AU - Van Kerrebroeck, P.
T1 - The role of neuromodulation in the management of urinary urge incontinence.
JO - BJU International
JF - BJU International
Y1 - 2003/03//
VL - 91
IS - 4
M3 - Article
SP - 355
EP - 359
PB - Wiley-Blackwell
SN - 14644096
AB - Neuromodulation is increasingly becoming an important part of the treatment strategy for bladder dysfunction. In this issue a group of urologists have analysed outcome measures from all patients in pivotal clinical trials who have had this treatment, and have suggested that sacral nerve stimulation has an vital role in the management of refractory overactive bladder and retention problems. In a carefully performed study, authors from Mansoura and Scottsdale have evaluated high-energy TUMT and found that although symptomatic improvement occurred in 82.5% of patients, and that the peak flow rate improved from a median of 9.2 to 15 mL/s, pressure-flow improvement occurred in just 50% of the group. However, they found that younger patient age and higher grade of obstruction, are good predictors of urodynamic and symptomatic success respectively. In another study, Marshall's group from Adelaide emphasize the value of urodynamics and other factors in patients having TURP. The value of trans-abdominal ultrasound is described by Foo and his colleagues from Singapore, who state that intravesical protrusion of the prostate is an important indicator of bladder outlet obstruction. OBJECTIVE To examine the benefit-risk profile of neuromodulation in treating refractory urinary urge incontinence and other voiding disorders. PATIENTS AND METHODS The outcome measures from all patients in pivotal clinical trials who had undergone sacral nerve stimulation were analysed retrospectively. RESULTS Neuromodulation was effective in several clinical studies; the response is durable and the benefit-risk profile good. CONCLUSION Sacral nerve stimulation is becoming the standard of care for refractory overactive bladder and retention problems. The potential benefit of neuromodulation should be included in female urology and gynaecology training programmes. [ABSTRACT FROM AUTHOR]
AB - Copyright of BJU International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINARY incontinence -- Treatment
KW - URINATION disorders
KW - neuromodulation
KW - neurourology
KW - outcome
KW - Urinary urge incontinence
N1 - Accession Number: 9191042; Abrams, P. 1 Blaivas, J.G. 2 Fowler, C.J. 3 Fourcroy, J.L. 4 Macdiarmid, S.A. 5 Siegel, S.W. 6 Van Kerrebroeck, P. 7; Affiliation: 1: Bristol Urological Institute, Southmead Hospital, Bristol, UK, 2: Urocentre of New York, New York, USA, 3: Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK, 4: Office of Health Affairs, Food and Drug Administration, Bethesda, Maryland, 5: Department of Urology, University of Tennessee, Memphis, TN, USA, 6: Center for Continence Care, Metropolitan Urologic Specialists, St Paul, MN, USA, and 7: Department of Urology, University Hospital Maastricht, Maastricht, the Netherlands; Source Info: Mar2003, Vol. 91 Issue 4, p355; Subject Term: URINARY incontinence -- Treatment; Subject Term: URINATION disorders; Author-Supplied Keyword: neuromodulation; Author-Supplied Keyword: neurourology; Author-Supplied Keyword: outcome; Author-Supplied Keyword: Urinary urge incontinence; Number of Pages: 5p; Document Type: Article
L3 - 10.1046/j.1464-410X.2003.04105.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horvath-Arcidiacono, Judith A.
AU - Tsuyuki, Shigeru
AU - Mostowski, Howard
AU - Bloom, Eda T.
T1 - Human natural killer cell activity against porcine targets: modulation by control of the oxidation–reduction environment and role of adhesion molecule interactions
JO - Cellular Immunology
JF - Cellular Immunology
Y1 - 2003/03//
VL - 222
IS - 1
M3 - Article
SP - 35
SN - 00088749
AB - Xenotransplantation, especially using porcine sources, has been proposed as a means to alleviate the shortage of human organs for transplantation. NK cells appear to be important mediators of the xenogeneic immune responses, including the human anti-pig response. Having previously established the redox regulation of NK cell activity against tumor target cells, we now report that the interaction of human NK cells with porcine target cells is also regulated by redox. Thiol-deprivation strongly diminished the capacity of IL-2-activated human NK cells to kill porcine endothelial cells. This inhibition correlated with reduced proliferation and interferon (IFN)-γ production by IL-2-activated NK cells. For fresh NK cells, pretreatment with diethyl maleate (DEM), which was used to deplete intracellular thiols, reduced lysis of porcine and human targets. Because many adhesion molecules exhibit interspecies recognition, we further investigated whether changes in expression of adhesion molecules might explain our observations. DEM treatment reduced the expression of CD11b and CD29 on fresh NK cells. Monoclonal antibody blocking studies showed that the combination of mAb to CD11b and CD18 reduced lytic activity against both PAEC as well as K562, although other qualitative differences were observed between the porcine and human target cells. These findings suggest that the oxidative stress-induced downregulation of CD18 may be important in modulating cytotoxic activity of fresh NK cells against PAEC and K562 targets through reduced formation of the CD11b/CD18 heterodimer. Thus, the appropriate manipulation of redox status may provide a means to enhance survival of non-human animal tissues in humans through modulation of adhesion molecule expression/interactions. [Copyright &y& Elsevier]
AB - Copyright of Cellular Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - TRANSPLANTATION of organs, tissues, etc.
KW - Adhesion molecules
KW - Endothelial cells
KW - Human
KW - NK cells
KW - Transplantation
N1 - Accession Number: 9948628; Horvath-Arcidiacono, Judith A. 1 Tsuyuki, Shigeru 1 Mostowski, Howard 1 Bloom, Eda T.; Email Address: bloom@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Mar2003, Vol. 222 Issue 1, p35; Subject Term: KILLER cells; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Author-Supplied Keyword: Adhesion molecules; Author-Supplied Keyword: Endothelial cells; Author-Supplied Keyword: Human; Author-Supplied Keyword: NK cells; Author-Supplied Keyword: Transplantation; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0008-8749(03)00082-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lenz, Petra
AU - Thompson, Cynthia D.
AU - Day, Patricia M.
AU - Bacot, Silvia M.
AU - Lowy, Douglas R.
AU - Schiller, John T.
T1 - Interaction of papillomavirus virus-like particles with human myeloid antigen-presenting cells
JO - Clinical Immunology
JF - Clinical Immunology
Y1 - 2003/03//
VL - 106
IS - 3
M3 - Article
SP - 231
SN - 15216616
AB - Papillomavirus-like particles (VLPs) are potent inducers of humoral and cellular immune responses, making them attractive candidates for noninfectious viral subunit vaccines. To further our understanding of how VLPs activate the immune system, we have investigated their interaction with human myeloid antigen-presenting cells. We found that VLPs bound, with increasing density, to the cell surface of human monocytes, macrophages, and monocyte-derived dendritic cells (DCs). Interestingly, there was a negative correlation between binding intensity and CD83 expression in DCs, suggesting that the main receptor for binding of VLPs may be downregulated during maturation. Exposure to VLPs resulted in acute phenotypic activation of monocytes and DCs. Furthermore, VLPs rapidly induced production of inflammatory cytokines in monocytes, macrophages, and DCs, as assessed by intracellular cytokine staining. For each cell type, the patterns of interleukin-1β, interleukin-12, tumor necrosis factor-α, and interleukin-6 production were distinct from the pattern induced by lipopolysaccharide (LPS), a bacterial activator of myeloid antigen-presenting cells. Our results indicate that VLPs target multiple cells of the immune system, which helps to account for VLPs being so effective in priming humoral and cellular immune responses even in the absence of adjuvant. [Copyright &y& Elsevier]
AB - Copyright of Clinical Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAPILLOMAVIRUSES
KW - DENDRITIC cells
KW - Dendritic cells
KW - Inflammatory cytokines
KW - Macrophages
KW - Monocytes
KW - Papillomavirus
KW - Vaccine
KW - Virus-like particles
N1 - Accession Number: 9495989; Lenz, Petra 1 Thompson, Cynthia D. 1 Day, Patricia M. 1 Bacot, Silvia M. 2 Lowy, Douglas R. 1 Schiller, John T. 1; Email Address: schillej@dc37a.nci.nih.gov; Affiliation: 1: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Mar2003, Vol. 106 Issue 3, p231; Subject Term: PAPILLOMAVIRUSES; Subject Term: DENDRITIC cells; Author-Supplied Keyword: Dendritic cells; Author-Supplied Keyword: Inflammatory cytokines; Author-Supplied Keyword: Macrophages; Author-Supplied Keyword: Monocytes; Author-Supplied Keyword: Papillomavirus; Author-Supplied Keyword: Vaccine; Author-Supplied Keyword: Virus-like particles; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S1521-6616(02)00039-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Galanaud, Jean-Philippe
AU - Delavennat, Juliette
AU - Durand-Zaleski, Isabelle
T1 - A break-even price calculation for the use of sirolimus-eluting stents in angioplasty
JO - Clinical Therapeutics
JF - Clinical Therapeutics
Y1 - 2003/03//
VL - 25
IS - 3
M3 - Article
SP - 1007
SN - 01492918
AB - Background: One of the major complications of angioplasty is the early occurrence of restenosis requiring a repeat procedure. When bare-metal stents are used, clinical restenosis results in a repeat procedure in 10% to 15% of cases. Based on the results of an international, randomized clinical trial, the use of sirolimus-eluting stents reduces this risk.Objectives: The aims of this study were to calculate the theoretical break-even price for sirolimus-eluting stents in France, the Netherlands, and the United States, and to determine the additional health care cost per patient.Methods: The break-even price was calculated by adding the savings resulting from a 15% decrease in the rate of clinical restenosis to the price of bare-metal stents. Costs were computed from the viewpoint of the health care system, exclusive of the other societal costs.Results: The break-even prices were €1291 to €1489 in France, €2028 in the Netherlands, and €2708 in the United States (€1.00 = US $1.00 in purchasing power parity). These results indicate that the commercial price of sirolimus-eluting stents will increase hospital spending for patients undergoing angioplasty by 17% to 55% per patient.Conclusion: This additional cost to the health care system should be discussed in view of possible productivity savings and improved quality of life for patients. [Copyright &y& Elsevier]
AB - Copyright of Clinical Therapeutics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY restenosis
KW - ANGIOPLASTY
KW - CLINICAL trials
KW - angioplasty
KW - restenosis
KW - sirolimus
KW - stents
N1 - Accession Number: 10233844; Galanaud, Jean-Philippe 1 Delavennat, Juliette 1 Durand-Zaleski, Isabelle; Email Address: isabelle.durand-zaleski@hmn.ap-hop-paris.fr; Affiliation: 1: Public Health Service, Henri Mondor Hospital, Public Assistance Hospitals of Paris, Paris, France; Source Info: Mar2003, Vol. 25 Issue 3, p1007; Subject Term: CORONARY restenosis; Subject Term: ANGIOPLASTY; Subject Term: CLINICAL trials; Author-Supplied Keyword: angioplasty; Author-Supplied Keyword: restenosis; Author-Supplied Keyword: sirolimus; Author-Supplied Keyword: stents; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106854385
T1 - A break-even price calculation for the use of sirolimus-eluting stents in angioplasty.
AU - Galanaud J
AU - Delavennat J
AU - Durand-Zaleski I
Y1 - 2003/03//
N1 - Accession Number: 106854385. Language: English. Entry Date: 20030801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7706726.
KW - Angioplasty -- Methods
KW - Antibiotic Prophylaxis
KW - Cost Benefit Analysis
KW - Economics, Pharmaceutical
KW - Stents -- Utilization
KW - Comparative Studies
KW - Cost Savings
KW - France
KW - Health Care Costs -- Evaluation
KW - Netherlands
KW - Prospective Studies
KW - Quality of Life
KW - Sensitivity and Specificity
KW - United States
KW - Human
SP - 1007
EP - 1016
JO - Clinical Therapeutics
JF - Clinical Therapeutics
JA - CLIN THER
VL - 25
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - BACKGROUND: One of the major complications of angioplasty is the early occurrence of restenosis requiring a repeat procedure. When bare-metal stents are used, clinical restenosis results in a repeat procedure in 10% to 15% of cases. Based on the results of an international, randomized clinical trial, the use of sirolimus-eluting stents reduces this risk. OBJECTIVES: The aims of this study were to calculate the theoretical break-even price for sirolimus-eluting stents in France, the Netherlands, and the United States, and to determine the additional health care cost per patient. METHODS: The break-even price was calculated by adding the savings resulting from a 15% decrease in the rate of clinical restenosis to the price of bare-metal stents. Costs were computed from the viewpoint of the health care system, exclusive of other societal costs. RESULTS: The break-even prices were 1291 Euro to 1489 Euro in France, 2028 Euro in the Netherlands, and 2708 Euroin the United States (1.00 Euro = 1.00 US dollar in purchasing power parity). These results indicate that the commercial price of sirolimuseluting stents will increase hospital spending for patients undergoing angioplasty by 17% to 55% per patient. CONCLUSION: This additional cost to the health care system should be discussed in view of possible productivity savings and improved quality of life for patients.
SN - 0149-2918
AD - Public Health Service, Henri Mondor Hospital, Public Assistance Hospitals of Paris, Paris, France
U2 - PMID: 12852715.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Myers, M.J.
AU - Farrell, D.E.
AU - Evock-Clover, C.M.
AU - Steele, N.C.
T1 - Long-term recombinant porcine somatotropin (PST) treatment mitigates the responses to subchronic lipopolysaccharide in swine
JO - Domestic Animal Endocrinology
JF - Domestic Animal Endocrinology
Y1 - 2003/03//
VL - 24
IS - 2
M3 - Article
SP - 155
SN - 07397240
AB - The effect of multiple lipopolysaccharide (LPS) challenges in swine undergoing long-term treatment with porcine somatotropin (PST) was determined. Changes in aspartate serine transaminase (AST) occurred only at 24 h following the first LPS challenge dose (P<0.05 ), while PST treatment moderated any change from occurring. Nonesterified free fatty acid (NEFA) levels were elevated in PST treated animals for the first 3 days following daily LPS treatment (P<0.05 ), while LPS treatment alone had no effect on plasma NEFA levels. Plasma urea nitrogen (PUN) levels were unchanged by LPS following the initial LPS challenge, but were decreased following the second challenge dose (P=0.014 ). These changes were long lasting, with a return to normal PUN levels not evident until Day 6. The PST treatment mitigated changes in PUN (P<0.05 ) when LPS was administered. Haptoglobin plasma levels, along with lipid peroxide production were not affected by LPS challenge or PST administration. LPS challenge reduced the levels of immunoreactive heat shock protein 70 (HSP70) throughout the entire challenge period (P<0.001 ). PST–LPS animals had normal levels of this protein. The results of the present study demonstrate that long-term PST treatment mitigates the adverse effects of subchronic LPS administration. [Copyright &y& Elsevier]
AB - Copyright of Domestic Animal Endocrinology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEAT shock proteins
KW - INSULIN
KW - Aspartate transaminase
KW - Glucose
KW - Heat shock protein 70
KW - Insulin
KW - Urea nitrogen
N1 - Accession Number: 9053735; Myers, M.J. 1; Email Address: mmyers@cvm.fda.gov Farrell, D.E. 1 Evock-Clover, C.M. 2 Steele, N.C. 2; Affiliation: 1: Division of Animal Research, US FDA, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA 2: Growth Biology Laboratory, USDA/Agricultural Research Service, BARC-East, Bldg. 200, Beltsville, MD 20705, USA; Source Info: Mar2003, Vol. 24 Issue 2, p155; Subject Term: HEAT shock proteins; Subject Term: INSULIN; Author-Supplied Keyword: Aspartate transaminase; Author-Supplied Keyword: Glucose; Author-Supplied Keyword: Heat shock protein 70; Author-Supplied Keyword: Insulin; Author-Supplied Keyword: Urea nitrogen; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/S0739-7240(02)00234-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9053735&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106836553
T1 - Substance abuse treatment need among older adults in 2020: the impact of the aging baby-boom cohort.
AU - Gfroerer J
AU - Penne M
AU - Pemberton M
AU - Folsom R
Y1 - 2003/03//
N1 - Accession Number: 106836553. Language: English. Entry Date: 20030530. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: SAMHSA contract 283-99-0003. NLM UID: 7513587.
KW - Substance Abuse -- Therapy -- In Middle Age
KW - Baby Boomers -- In Middle Age
KW - Substance Dependence -- Therapy -- In Middle Age
KW - Female
KW - Male
KW - Middle Age
KW - Regression
KW - Prospective Studies
KW - Funding Source
KW - Surveys
KW - Predictive Research
KW - Interviews
KW - Logistic Regression
KW - Coefficient Alpha
KW - Data Analysis Software
KW - Confidence Intervals
KW - Age Factors
KW - Sex Factors
KW - Age of Onset
KW - Prevalence
KW - Human
SP - 127
EP - 135
JO - Drug & Alcohol Dependence
JF - Drug & Alcohol Dependence
JA - DRUG ALCOHOL DEPENDENCE
VL - 69
IS - 2
PB - Elsevier Science
AB - BACKGROUND: There is concern that as the baby boom population ages in the US, there will be a substantial increase in the number of older adults needing treatment for substance abuse problems. To address this concern, projections of future treatment need for older adults (defined as age 50 and older) were made. METHODS: Using data from the National Household Survey on Drug Abuse, regression models including predictors of treatment need in 2000 and 2001 were developed. Treatment need was defined as having a DSM-IV alcohol or illicit drug use disorder in the past year. Regression parameters from these models were applied to the projected 2020 population to obtain estimates of the number of older adults needing treatment in 2020. RESULTS: The number of older adults in need of substance abuse treatment is estimated to increase from 1.7 million in 2000 and 2001 to 4.4 million in 2020. This is due to a 50 percent increase in the number of older adults and a 70 percent increase in the rate of treatment need among older adults. CONCLUSIONS: The aging baby boom cohort will place increasing demands on the substance abuse treatment system in the next two decades, requiring a shift in focus to address the special needs of an older population of substance abusers. There is also a need to develop improved tools for measuring substance use and abuse among older adults.
SN - 0376-8716
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Room 16-105, 5600 Fishers Lane, Rockville, MD 20857; jgfroere@samhsa.gov
U2 - PMID: 12609694.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106836553&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Paoletti, M. G.
AU - Buscardo, E.
AU - Vanderjagt, D. J.
AU - Pastuszyn, A.
AU - Pizzoferrato, L.
AU - Y.-S. Huang
AU - L.-T. Chuang
AU - Glew, R. H.
AU - Millson, M.
AU - Cerda, H.
T1 - NUTRIENT CONTENT OF TERMITES SYNTERMES SOLDIERS) CONSUMED BY MAKIRITARE AMERINDIANS OF THE ALTO ORINOCO OF VENEZUELA.
JO - Ecology of Food & Nutrition
JF - Ecology of Food & Nutrition
Y1 - 2003/03//Mar/Apr2003
VL - 42
IS - 2
M3 - Article
SP - 177
EP - 191
SN - 03670244
AB - Termites seri (especially Syntermes aculeosus soldiers) are collected extensively by Makiritare (or Ye'Kuana Indians in the Alto Orinoco) and consumed raw or after soaking in hot water (60°-80°C). They are gathered be means of "termite fishing" technique and then transported into a package called kukuruciu made with Musacean (Phenakospermum sp.) leaves. The solders of Syntermes constitute a food source of great nutritional value: high in proteins and essential amino acids such as trytophan, which is generally limiting in the food insects. Abundant are minerals such as iron and calcium together with micronutrients. Essential fatty acids are well represented. In general, heads of seri are better nutritionally featured than thorax and abdomens (not eaten by the Makiritare but comsumed by the Piaroa Indians). [ABSTRACT FROM AUTHOR]
AB - Copyright of Ecology of Food & Nutrition is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Termites
KW - Food
KW - Nutrition
KW - Yecuana (South American people)
KW - Hot water
KW - Venezuela
KW - Alto Orinoco
KW - Makiritare Indians
KW - nutrient content
KW - Syntermes soldiers
KW - termites
N1 - Accession Number: 27084858; Paoletti, M. G. 1; Email Address: paoletti@civ.bio.unipd.it; Buscardo, E. 1; Vanderjagt, D. J. 2; Pastuszyn, A. 2; Pizzoferrato, L. 3; Y.-S. Huang 4; L.-T. Chuang 4; Glew, R. H. 4; Millson, M. 5; Cerda, H. 6; Affiliations: 1: Department of Biology, University of Padova, Padova, Italy; 2: Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA; 3: National Institute of Nutrition, Rome, Italy; 4: Ross Division, Abbott Laboratories, Inc., Columbus, Ohio, USA; 5: National Institute of Occupational Safety and Health, Columbus, Ohio, USA; 6: Simon Rodriguez University, Caracas, Venezuela; Issue Info: Mar/Apr2003, Vol. 42 Issue 2, p177; Thesaurus Term: Termites; Thesaurus Term: Food; Thesaurus Term: Nutrition; Subject Term: Yecuana (South American people); Subject Term: Hot water; Subject: Venezuela; Author-Supplied Keyword: Alto Orinoco; Author-Supplied Keyword: Makiritare Indians; Author-Supplied Keyword: nutrient content; Author-Supplied Keyword: Syntermes soldiers; Author-Supplied Keyword: termites; Number of Pages: 16p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/036702403902-2255
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27084858&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shade, Lindsay
AU - Beger, Richard D.
AU - Wilkes, Jon G.
T1 - THE USE OF CARBON THIRTEEN NUCLEAR MAGNETIC RESONANCE SPECTRA TO PREDICT DIOXIN AND FURAN BINDING AFFINITIES TO THE ARYL HYDROCARBON RECEPTOR.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2003/03//
VL - 22
IS - 3
M3 - Article
SP - 501
EP - 509
SN - 07307268
AB - Four spectroscopic data--activity relationship (SDAR) models for polychlorinated dibenzofurans (PCDFs) and diben-zodioxins (PCDDs) binding to the aryl hydrocarbon receptor (AhR) have been developed based on simulated 13C nuclear magnetic resonance (NMR) data. Models were developed using discriminant function analysis of the compounds' spectral data. An SDAR model with two classifications for 26 PCDF compounds had a leave-one-out (LOO) cross-validation accuracy of 89%. A two-classification SDAR model for 14 PCDD compounds had LOO cross-validation accuracy of 95%. A two-classification SDAR model combining 14 PCDD and 26 PCDF compounds had LOO cross-validation accuracy of 88%, while a four-classification SDAR model based on the same 14 PCDD and 26 PCDF compounds had LOO cross-validation accuracy of 92%. We used each appropriate SDAR model to classify 41 PCDD and/or 121 PCDF compounds with unknown binding affinities to the AhR. The SDAR models provide a rapid, simple, and valid way to model the PCDF and PCDD binding activity in relation to the AhR. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON
KW - NUCLEAR magnetic resonance
KW - DIOXINS
KW - CHEMICALS
KW - BIOCHEMISTRY
KW - Aryl hydrocarbon receptor
KW - Polychlorodibenzo-p-dioxins
KW - Polychlorodibenzofurans
KW - Spectroscopic data--activity relationships
N1 - Accession Number: 15940610; Shade, Lindsay 1 Beger, Richard D. 1 Wilkes, Jon G. 1; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Source Info: Mar2003, Vol. 22 Issue 3, p501; Subject Term: CARBON; Subject Term: NUCLEAR magnetic resonance; Subject Term: DIOXINS; Subject Term: CHEMICALS; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Aryl hydrocarbon receptor; Author-Supplied Keyword: Polychlorodibenzo-p-dioxins; Author-Supplied Keyword: Polychlorodibenzofurans; Author-Supplied Keyword: Spectroscopic data--activity relationships; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 9p; Illustrations: 3 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106716432
T1 - Pathways to access: health insurance, the health care delivery system, and racial/ethnic disparities, 1996-1999: insurance matters, but so do other factors, when it comes to explaining differences in levels of access among racial and ethnic groups.
AU - Zuvekas SH
AU - Taliaferro GS
Y1 - 2003/03//Mar/Apr2003
N1 - Accession Number: 106716432. Language: English. Entry Date: 20040326. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Health Services Accessibility -- Trends
KW - Insurance, Health
KW - Race Factors
KW - Adult
KW - Blacks
KW - Descriptive Statistics
KW - Educational Status
KW - Employment Status
KW - Female
KW - Hispanics
KW - Male
KW - Middle Age
KW - Socioeconomic Factors
KW - Whites
KW - Human
SP - 139
EP - 153
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 22
IS - 2
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - We examine the roles that insurance coverage, the delivery system, and external factors play in explaining persistent disparities in access among racial and ethnic groups of all ages. Using data from the 1996-1999 Medical Expenditure Panel Surveys and regression-based decomposition methods, we find that our measures of health care system capacity explain little and that while insurance clearly matters, external factors are equally important. Employment, job characteristics, and marital status are key determinants of disparities in access to insurance but are difficult for health policy to affect directly. Much of existing disparities remains unexplained, presenting a challenge to developing policies to eliminate them.
SN - 0278-2715
AD - Senior Economist, Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 12674417.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106716432&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clauser, Steven B.
AU - Bierman, Arlene S.
T1 - Significance of Functional Status Data for Payment and Quality.
JO - Health Care Financing Review
JF - Health Care Financing Review
Y1 - 2003///Spring2003
VL - 24
IS - 3
M3 - Article
SP - 1
EP - 12
PB - HCFA ORDS Publications
SN - 01958631
AB - To date, the Medicare Program has used functional status information (FSI) in patient assessment tools, performance assessment, payment mechanisms, and-- most recently--in quality measures to inform consumer choice. This article explores the rationale for the collection of functional status data to promote innovative models of care and examines issues related to data collection for quality improvement, performance measurement, and payment. In this issue of the Health Care Financing Review, articles focus on collection and classification of functional status for payment and quality purposes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Care Financing Review is the property of HCFA ORDS Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE
KW - HEALTH insurance
KW - MEDICAL history taking
KW - MEDICAL records
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 11203839; Clauser, Steven B. 1; Email Address: clausers@mail.nih.gov; Bierman, Arlene S. 2; Affiliations: 1: National Cancer Institute, Division of Cancer Control and Population Sciences, 6130 Executive Boulevard, MSC 7344, EPN Room 4005, Bethesda, MD 20892-7344; 2: Agency for Healthcare Research and Quality; Issue Info: Spring2003, Vol. 24 Issue 3, p1; Thesaurus Term: MEDICARE; Thesaurus Term: HEALTH insurance; Subject Term: MEDICAL history taking; Subject Term: MEDICAL records; Subject Term: MEDICAL policy; Subject: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wu, J.Z.
AU - Dong, R.G.
AU - Smutz, W.P.
AU - Schopper, A.W.
T1 - Modeling of time-dependent force response of fingertip to dynamic loading
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2003/03//
VL - 36
IS - 3
M3 - Article
SP - 383
SN - 00219290
AB - An extended exposure to repeated loading on fingertip has been associated to many vascular, sensorineural, and musculoskeletal disorders in the fingers, such as carpal tunnel syndrome, hand–arm vibration syndrome, and flexor tenosynovitis. A better understanding of the pathomechanics of these sensorineural and vascular diseases in fingers requires a formulation of a biomechanical model of the fingertips and analyses to predict the mechanical responses of the soft tissues to dynamic loading. In the present study, a model based on finite element techniques has been developed to simulate the mechanical responses of the fingertips to dynamic loading. The proposed model is two-dimensional and incorporates the essential anatomical structures of a finger: skin, subcutaneous tissue, bone, and nail. The skin tissue is assumed to be hyperelastic and viscoelastic. The subcutaneous tissue was considered to be a nonlinear, biphasic material composed of a hyperelastic solid and an invicid fluid, while its hydraulic permeability was considered to be deformation dependent. Two series of numerical tests were performed using the proposed finger tip model to: (a) simulate the responses of the fingertip to repeated loading, where the contact plate was assumed to be fixed, and the bone within the fingertip was subjected to a prescribed sinusoidal displacement in vertical direction; (b) simulate the force response of the fingertip in a single keystroke, where the keyboard was composed of a hard plastic keycap, a rigid support block, and a nonlinear spring. The time-dependent behavior of the fingertip under dynamic loading was derived. The model predictions of the time-histories of force response of the fingertip and the phenomenon of fingertip separation from the contacting plate during cyclic loading agree well with the reported experimental observations. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCULOSKELETAL system -- Diseases
KW - FINITE element method
KW - Fingertip
KW - Finite element model
KW - Hyperelastic
KW - Poroelastic
KW - Soft tissue mechanics
N1 - Accession Number: 9097600; Wu, J.Z.; Email Address: jwu@cdc.gov Dong, R.G. 1 Smutz, W.P. 1 Schopper, A.W. 1; Affiliation: 1: E&CTB/HELD, National Institute for Occupational Safety and Health, Center for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Mar2003, Vol. 36 Issue 3, p383; Subject Term: MUSCULOSKELETAL system -- Diseases; Subject Term: FINITE element method; Author-Supplied Keyword: Fingertip; Author-Supplied Keyword: Finite element model; Author-Supplied Keyword: Hyperelastic; Author-Supplied Keyword: Poroelastic; Author-Supplied Keyword: Soft tissue mechanics; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0021-9290(02)00427-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9097600&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boam, Ashley B.
AU - Eydelman, Malvina B.
AU - Lum, Flora C.
AU - Silverman, Phyllis M.
AU - Apple, David J.
AU - Werner, Liliana
AU - Pandey, Suresh K.
T1 - Retrospective evaluation of intraocular lenses in adults younger than 60 years
JO - Journal of Cataract & Refractive Surgery
JF - Journal of Cataract & Refractive Surgery
Y1 - 2003/03//
VL - 29
IS - 3
M3 - Article
SP - 575
SN - 08863350
AB - Data from the U.S. Food and Drug Administration, the American Academy of Ophthalmology’s National Eyecare Outcomes Network, and Storm Eye Institute databases were analyzed for short- and long-term safety and efficacy outcomes of intraocular lens (IOL) implantation in adults younger than 60 years and 60 years and older. Statistical analyses for significance were performed where appropriate. A comprehensive literature review was conducted to identify safety and efficacy outcomes and their relationship to patient age at the time of implantation. Analyses established that the performance of IOLs in adults younger than 60 years was comparable to that in adults older than 60 years and supported the use of IOLs in the younger adult population. [Copyright &y& Elsevier]
AB - Copyright of Journal of Cataract & Refractive Surgery is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAOCULAR lenses
KW - ARTIFICIAL implants
N1 - Accession Number: 9343805; Boam, Ashley B. 1 Eydelman, Malvina B. 1 Lum, Flora C. 2 Silverman, Phyllis M. 1 Apple, David J. 3 Werner, Liliana 3 Pandey, Suresh K. 3; Affiliation: 1: U.S. Food and Drug Administration, Rockville, Maryland (Boam, Eydelman, Silverman), USA 2: American Academy of Ophthalmology, San Francisco, California (Lum), USA 3: Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina (Apple, Werner, Pandey), USA; Source Info: Mar2003, Vol. 29 Issue 3, p575; Subject Term: INTRAOCULAR lenses; Subject Term: ARTIFICIAL implants; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0886-3350(02)01845-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9343805&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beck, Patricia
AU - Wysowski, Diane K.
AU - Downey, Winanne
AU - Butler-Jones, David
T1 - Statin use and the risk of breast cancer
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2003/03//
VL - 56
IS - 3
M3 - Article
SP - 280
SN - 08954356
AB - The study objective was to investigate a possible association between statin use and breast cancer (BRCA). An historical cohort design based on Saskatchewan''s population health services databases was used. All eligible women with ⩾1 statin prescription from 1989 to mid-1997 and an age–sex-matched nonexposed group were followed up to 8.5 years (mean 4.2 years). Relative rates (RR) of BRCA were estimated and stratified by age, statin exposure time, and prior hormone use. Thirteen thousand five hundred ninety-two statin users and 53,880 nonexposed subjects were identified. Eight hundred seventy-nine incident BRCA cases were identified. Statins were not associated with BRCA risk in women ⩽55 years. Among subjects >55 years, the RR for BRCA was 1.15 (0.97, 1.37). Stratified analyses revealed increases in risk in short-term statin users and statin users with long-term hormone replacement therapy (HRT) exposure. More studies are needed to determine if short-term statin use and statin use with long-term HRT exposure increases postmenopausal BRCA risk. Published by Elsevier Science Inc. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Epidemiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATINS (Cardiovascular agents)
KW - BREAST cancer
KW - ANTILIPEMIC agents
KW - Breast cancer
KW - Hormone replacement therapy
KW - Lipid-lowering drugs
KW - Postmenopausal women
KW - Saskatchewan
KW - Statin drugs
N1 - Accession Number: 9603924; Beck, Patricia 1; Email Address: pbeck@health.gov.sk.ca Wysowski, Diane K. 2 Downey, Winanne 1 Butler-Jones, David 1; Affiliation: 1: Saskatchewan Health, Population Health Branch, 3475 Albert Street, Regina SK S4S 6X6, Canada 2: Division of Drug Risk Evaluation, HFD-430, Food and Drug Administration, Parklawn Building, Room 15B-08, Rockville, MD 20857, USA; Source Info: Mar2003, Vol. 56 Issue 3, p280; Subject Term: STATINS (Cardiovascular agents); Subject Term: BREAST cancer; Subject Term: ANTILIPEMIC agents; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: Hormone replacement therapy; Author-Supplied Keyword: Lipid-lowering drugs; Author-Supplied Keyword: Postmenopausal women; Author-Supplied Keyword: Saskatchewan; Author-Supplied Keyword: Statin drugs; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0895-4356(02)00614-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9603924&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106822875
T1 - Beyond child protection: promoting mental health for children and families in the child welfare system.
AU - Webb MB
AU - Harden BJ
Y1 - 2003///Spring2003
N1 - Accession Number: 106822875. Language: English. Entry Date: 20030418. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9306047.
KW - Child Welfare
KW - Public Policy
KW - Mental Health Services -- In Infancy and Childhood
KW - Child
KW - Child, Preschool
KW - Adolescence
KW - Infant
KW - Courts
KW - Decision Making
KW - Adoption -- In Infancy and Childhood
KW - Child Welfare -- Legislation and Jurisprudence -- United States
KW - United States
KW - Legislation
KW - Economic and Social Security
KW - Medicaid
KW - Government Programs
KW - Managed Care Programs
KW - Foster Home Care -- In Infancy and Childhood
KW - Mental Health -- In Infancy and Childhood
KW - Culture
KW - Race Factors
SP - 49
EP - 58
JO - Journal of Emotional & Behavioral Disorders
JF - Journal of Emotional & Behavioral Disorders
JA - J EMOTIONAL BEHAV DISORD
VL - 11
IS - 1
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - The child welfare system is in a period of significant reform that offers both opportunities and challenges regarding more effective collaboration between the mental health and child welfare systems. In this article we examine recent federal, state, and local initiatives that have influenced child welfare policy and practice on a national scale, with particular emphasis on those policies that offer opportunities for better coordination of services between mental health and child welfare agencies. To plan for effective services, mental health policy makers and practitioners must be cognizant of available funding streams for child welfare, trends and innovations within the child welfare system, the contextual factors that shape services to the children and families who are under its supervision, and the special characteristics of the population that it serves.
SN - 1063-4266
AD - US Department of Health and Human Services, Administration for Children and Families, 370 L'Entant Promenade, Washington, DC 20447
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106822875&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Greenberg, George D.
AD - US Department of Health and Human Services
T1 - Policy Analysis at the Department of Health and Human Services, Then and Now
JO - Journal of Policy Analysis and Management
JF - Journal of Policy Analysis and Management
Y1 - 2003///Spring
VL - 22
IS - 2
SP - 304
EP - 307
SN - 02768739
N1 - Accession Number: 0653604; Keywords: Health; Policy Analysis; Policy; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200307
KW - Positive Analysis of Policy Formulation and Implementation D78
KW - Project Evaluation; Social Discount Rate H43
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291520-6688/issues
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0653604&site=ehost-live&scope=site
UR - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291520-6688/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106656686
T1 - The role of federally funded health centers in serving the rural population.
AU - Regan J
AU - Schempf AH
AU - Yoon J
AU - Politzer RM
Y1 - 2003/03//
N1 - Accession Number: 106656686. Language: English. Entry Date: 20041029. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8508122.
KW - Health Services Accessibility
KW - Quality of Health Care
KW - Rural Health Services
KW - Adolescence
KW - Adult
KW - Aged
KW - Alcohol Drinking -- Epidemiology
KW - Child
KW - Child, Preschool
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Health Status
KW - Infant
KW - Interviews
KW - Male
KW - Middle Age
KW - Obesity -- Epidemiology
KW - P-Value
KW - Preventive Health Care
KW - Self Report
KW - Smoking -- Epidemiology
KW - T-Tests
KW - Human
SP - 117
EP - 124
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 19
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Context: Federally funded health centers attempt to improve rural health by reducing and eliminating access barriers to primary care services. Purpose: This study compares rural health center patients with people in the general rural population for indicators of access to preventive services and health outcomes. Methods: Data from the annual reporting system for federally funded health centers, the 1999 Uniform Data System, and published national census data were used to provide sociodemographic comparisons. Selected health status indicators, preventive services utilization, and health outcomes were obtained from a survey of health center patients, and the results were compared with the National Health Interview Survey and National Vital Statistics. Findings: Unlike the nation's rural population, the majority of rural health center patients are of minority race/ethnicity, live at or below poverty, and are either uninsured or on Medicaid. Despite having higher prevalence of traditional access barriers than the general rural population, rural health center patients are significantly more likely to receive certain preventive services and also to experience lower rates of low birthweight, particularly for African American infants. However, rural health center patients are not more likely to have received influenza vaccination or up-to-date mammogram screening. Conclusions: Health centers provide access to essential preventive care for many of the most vulnerable rural residents. A national strategy to expand the rural health center network will likely help to ensure improved health for the considerable proportion of rural residents who still lack access to appropriate services.
SN - 0890-765X
AD - Bureau of Primary Health Care, Health Resources and Services Administration, 4350 East West Hwy, 7th Floor, Bethesda, MD; jregan@hrsa.gov
U2 - PMID: 12696847.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sears, Johnna F.
AU - Khan, Arifa S.
T1 - Single-tube fluorescent product-enhanced reverse transcriptase assay with Ampliwax™ (STF-PERT) for retrovirus quantitation
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2003/03//
VL - 108
IS - 1
M3 - Article
SP - 139
SN - 01660934
AB - A TaqMan fluorescent probe-based product enhanced reverse transcriptase (RT) assay is described in which the RT and polymerase chain reaction (PCR) steps are set-up in a single tube, in two compartments separated by Ampliwax™ (designated as single-tube fluorescent product-enhanced reverse transcriptase assay (STF-PERT)). This simplification of the two-step method resulted in increased assay reproducibility and handling efficiency while maintaining the sensitivity of the PERT assay (<10 virions). The STF-PERT assay can be used to quantitate low amounts of retrovirus in clinical and research materials and to evaluate retrovirus contamination in cell substrates and biological products in human use. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REVERSE transcriptase
KW - POLYMERASE chain reaction
KW - Avian myeloblastosis virus
KW - Murine leukemia virus
KW - Polymerase chain reaction
KW - Retrovirus
KW - Reverse transcriptase
KW - TaqMan fluorescent probe-based product enhanced reverse transcriptase assay
N1 - Accession Number: 8998793; Sears, Johnna F. 1 Khan, Arifa S.; Email Address: khan@cber.fda.gov; Affiliation: 1: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Mar2003, Vol. 108 Issue 1, p139; Subject Term: REVERSE transcriptase; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Avian myeloblastosis virus; Author-Supplied Keyword: Murine leukemia virus; Author-Supplied Keyword: Polymerase chain reaction; Author-Supplied Keyword: Retrovirus; Author-Supplied Keyword: Reverse transcriptase; Author-Supplied Keyword: TaqMan fluorescent probe-based product enhanced reverse transcriptase assay; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S0166-0934(02)00287-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=8998793&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thai, Sheau-Fung
AU - Allen, James W.
AU - DeAngelo, Anthony B.
AU - George, Michael H.
AU - Fuscoe, James C.
T1 - Altered gene expression in mouse livers after dichloroacetic acid exposure
JO - Mutation Research/Reviews in Mutation Research
JF - Mutation Research/Reviews in Mutation Research
Y1 - 2003/03//
VL - 543
IS - 2
M3 - Article
SP - 167
SN - 13835742
AB - Dichloroacetic acid (DCA) is a major by-product of water disinfection by chlorination. Several studies have demonstrated that DCA exhibits hepatocarcinogenic effects in rodents when administered in drinking water. This chemical does not appear to be highly mutagenic, and the mechanism(s) involved in DCA induction of cancer are not clear. The present work was aimed at identifying changes in gene expression which may indicate critical alterations/pathways involved in this chemical’s carcinogenic activities. We used cDNA microarray methods for analyses of gene expression in livers of mice treated with the tumorigenic dose of 2 g/l DCA in drinking water for 4 weeks. Total RNA samples obtained from livers of the control and DCA-treated mice were evaluated for gene expression patterns with Clontech Atlas™ Mouse 1.2 cDNA and Atlas™ mouse stress/toxicology arrays, and the data analyzed with AtlasImage 2.01 and one-way ANOVA in JMP4 software. From replicate experiments, we identified 24 genes with altered expression, of which 15 were confirmed by Northern blot analysis. Of the 15 genes, 14 revealed expression suppressed two- to five-fold; they included the following: MHR 23A, cytochrome P450 (CYP) 2C29, CYP 3A11, serum paraoxonase/arylesterase 1 (PON 1), liver carboxylesterase, alpha-1 antitrypsin, ER p72, glutathione S-transferase (GST) Pi 1, angiogenin, vitronectin precursor, cathepsin D (CTSD), plasminogen precursor (contains angiostatin), prothrombin precursor and integrin alpha 3 precursor (ITGA 3). An additional gene, CYP 2A4/5, had a two-fold elevation in expression. Further, in ancillary Northern analyses of total RNA isolated from DCA-induced hepatocellular carcinomas (from earlier reported studies of mice treated with 3.5 g/l DCA for 93 weeks), many of the same genes (11 of 15) noted above showed a similar alteration in expression. In summary, we have identified specific genes involved in the functional categories of cell growth, tissue remodeling, apoptosis, cancer progression and xenobiotic metabolism that have altered levels of expression following exposures to DCA. These findings serve to highlight new pathways in which to further probe DCA effects that may be critical to its tumorigenic activity. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Reviews in Mutation Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acids
KW - Gene expression
KW - Dichloroacetic acid
KW - Mice
N1 - Accession Number: 9290754; Thai, Sheau-Fung 1; Email Address: thai.sheau-fung@epa.gov; Allen, James W. 1; DeAngelo, Anthony B. 1; George, Michael H. 1; Fuscoe, James C. 2; Affiliations: 1: Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Mail Drop 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA; 2: National Center for Toxicological Research, US Food and Drug Administration, Division of Genetic and Reproductive Toxicology, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Mar2003, Vol. 543 Issue 2, p167; Thesaurus Term: Acids; Subject Term: Gene expression; Author-Supplied Keyword: Dichloroacetic acid; Author-Supplied Keyword: Mice; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/S1383-5742(03)00014-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106821131
T1 - Device safety. Check that cable!
AU - Gallauresi BA
Y1 - 2003/03//
N1 - Accession Number: 106821131. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Defibrillators
KW - Equipment Failure
KW - Equipment Maintenance
SP - 76
EP - 76
JO - Nursing
JF - Nursing
JA - NURSING
VL - 33
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 12645588.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106821131&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106844748
T1 - Emerging foodborne pathogens.
AU - Acheson DWK
Y1 - 2003/03//2003 Mar
N1 - Accession Number: 106844748. Language: English. Entry Date: 20030627. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9877321.
KW - Food Poisoning -- Trends
KW - Food Poisoning -- Etiology
KW - Campylobacter Infections
KW - Listeria Infections
KW - Salmonella Infections
KW - Escherichia Coli Infections
KW - Virus Diseases
KW - Parasitic Diseases
KW - Encephalopathy, Bovine Spongiform
SP - 1
EP - 5
JO - Nutrition & the M.D.
JF - Nutrition & the M.D.
JA - NUTR MD
VL - 29
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0732-0167
AD - Chief Medical Officer, FDA Center for Food Safety and Applied Nutrition, College Park, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106884588
T1 - Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use.
AU - Calvo MS
AU - Whiting SJ
Y1 - 2003/03//
N1 - Accession Number: 106884588. Language: English. Entry Date: 20031114. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Vitamin D Deficiency -- Epidemiology -- Canada
KW - Vitamin D Deficiency -- Epidemiology -- United States
KW - United States
KW - Canada
KW - Adult
KW - Diet
KW - Reference Values
KW - Adolescence
KW - Seasons
KW - Female
KW - Male
KW - Middle Age
KW - Food, Fortified
KW - Milk
KW - Race Factors
KW - Blacks
KW - Whites
KW - Aged
SP - 107
EP - 113
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 61
IS - 3
PB - Oxford University Press / USA
SN - 0029-6643
AD - Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-025, 8301 Muirkirk Road, Laurel, MD 20708
U2 - PMID: 12723644.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106884588&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Knudsen, James F.
AU - Thambi, Lopa R.
AU - Kapcala, Leonard P.
AU - Racoosin, Judith A.
T1 - Oligohydrosis and fever in pediatric patients treated with zonisamide
JO - Pediatric Neurology
JF - Pediatric Neurology
Y1 - 2003/03//
VL - 28
IS - 3
M3 - Article
SP - 184
SN - 08878994
AB - Zonisamide is an antiepileptic drug developed and first marketed in Japan in 1989. Cases of oligohydrosis, characterized by deficient production and secretion of sweat, were reported in children treated with zonisamide in Japan during development and in the postmarketing period. Zonisamide was approved in the United States in March 2000 for adjunctive treatment of partial seizures in adults. Searching the Food and Drug Administration’s Adverse Events Reporting System, we identified six domestic cases of zonisamide-associated oligohydrosis and/or fever, all in patients ≤ 18 years of age. The calculated reporting rate was 13 cases per 10,000 pediatric-years of exposure, approximately 10–fold the reporting rate in Japan. A possible risk factor for the development of oligohydrosis in these cases was pediatric age, leading to exposure to elevated zonisamide blood levels relative to patient size. Although the mechanism for zonisamide-associated oligohydrosis has not been fully elucidated, the drug may mediate its effect on eccrine sweat glands by inhibiting carbonic anhydrase, thereby influencing pH dynamics, hydrogen ion concentration, and available calcium transients. Awareness of zonisamide-associated oligohydrosis may prevent morbidity, especially in the pediatric population. [Copyright &y& Elsevier]
AB - Copyright of Pediatric Neurology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTICONVULSANTS
KW - PEDIATRICS
N1 - Accession Number: 9857974; Knudsen, James F. 1 Thambi, Lopa R. 1 Kapcala, Leonard P. 2 Racoosin, Judith A. 1; Affiliation: 1: Center for Drug Evaluation and Research, Division of Neuropharmacological Drug Products, Rockville, Maryland, USA 2: Center for Drug Evaluation and Research, Office of Drug Safety, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Mar2003, Vol. 28 Issue 3, p184; Subject Term: ANTICONVULSANTS; Subject Term: PEDIATRICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0887-8994(02)00511-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106611658
T1 - Promoting the appropriate use of oral antibiotics: there is some very good news.
AU - Bauchner H
AU - Besser RE
Y1 - 2003/03//
N1 - Accession Number: 106611658. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Antibiotics -- Therapeutic Use
KW - Drug Resistance, Microbial
KW - Administration, Oral
KW - Child
KW - Drug Utilization
KW - Prescriptions, Drug
KW - United States
SP - 668
EP - 670
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 111
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Agency for Healthcare Research and Quality, Boston University School of Medicine/Boston Medical Center, Boston, MA 02118, USA. howard.bauchner@bmc.org
U2 - PMID: 12612251.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ritenbaugh, Cheryl
AU - Teufel-Shone, Nicolette I.
AU - Aickin, Mikel G.
AU - Joe, Jennie R.
AU - Poirier, Steven
AU - Dillingham, D.Clay
AU - Johnson, David
AU - Henning, Susanne
AU - Cole, Suzanne M.
AU - Cockerham, David
T1 - A lifestyle intervention improves plasma insulin levels among Native American high school youth
JO - Preventive Medicine
JF - Preventive Medicine
Y1 - 2003/03//
VL - 36
IS - 3
M3 - Article
SP - 309
SN - 00917435
AB - : BackgroundWorldwide, type 2 diabetes prevalence is increasing, with Native American populations particularly at risk. The Zuni Pueblo, with a history of wellness activities, volunteered to test the feasibility and efficacy of a high school-based diabetes prevention intervention.: MethodsThis school-based intervention used a multiple cross-sectional design to evaluate outcome measures at 0, 1.5, and 3 years against an Anglo comparison group. The Zuni high school diabetes prevention program included an educational component targeting decreased consumption of sugared beverages, knowledge of diabetes risk factors, and a youth-oriented fitness center. Main outcome measures were plasma glucose and insulin measured fasting and 30 min after a 75-g glucose challenge.: ResultsPlasma glucose levels were normal at baseline for Zuni (n = 72) and Anglo (n = 37) youth and did not significantly change throughout the study. At baseline, fasting and 30-min plasma insulin levels were significantly elevated for Zuni youth; they showed significant steady declines for both males and females throughout the study (P = 0.06 to P = 0.000 for trends using quantile regression). By Year 3, values for Zuni males (n = 29) equaled Anglo comparison values, while Zuni female (n = 26) values had declined but were still higher than Anglo comparison values.: ConclusionsAmong at-risk youth, an environmentally based lifestyle intervention may significantly suppress markers of type 2 diabetes risk. [Copyright &y& Elsevier]
AB - Copyright of Preventive Medicine is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN resistance
KW - INSULIN shock
KW - Adolescence
KW - Adolescent nutrition
KW - Diabetes mellitus, type 2
KW - Diet
KW - Epidemiology
KW - Exercise
KW - Hyperinsulinemia
KW - Indians, North American
KW - Insulin resistance
KW - Intervention studies
KW - Risk factors
KW - Soft drinks
N1 - Accession Number: 9233664; Ritenbaugh, Cheryl 1; Email Address: cheryl.ritenbaugh@kpchr.org Teufel-Shone, Nicolette I. 2 Aickin, Mikel G. 1 Joe, Jennie R. 2 Poirier, Steven 3 Dillingham, D.Clay 4 Johnson, David 2 Henning, Susanne 5 Cole, Suzanne M. 2 Cockerham, David 6; Affiliation: 1: Kaiser Permanente Center for Health Research, Portland, OR, USA 2: University of Arizona, Tucson, AZ, USA 3: Indian Health Service Zuni Diabetes Project, Zuni, NM, USA 4: National Center for Genome Research, Santa Fe, NM, USA 5: UCLA Center for Human Nutrition, Los Angeles, CA, USA 6: Zuni Public School District, Zuni, NM, USA; Source Info: Mar2003, Vol. 36 Issue 3, p309; Subject Term: INSULIN resistance; Subject Term: INSULIN shock; Author-Supplied Keyword: Adolescence; Author-Supplied Keyword: Adolescent nutrition; Author-Supplied Keyword: Diabetes mellitus, type 2; Author-Supplied Keyword: Diet; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Exercise; Author-Supplied Keyword: Hyperinsulinemia; Author-Supplied Keyword: Indians, North American; Author-Supplied Keyword: Insulin resistance; Author-Supplied Keyword: Intervention studies; Author-Supplied Keyword: Risk factors; Author-Supplied Keyword: Soft drinks; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0091-7435(02)00015-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dowdy, Janet
AU - Brower, Stacey
AU - Miller, Michael R.
T1 - Acetaminophen Exhibits Weak Antiestrogenic Activity in Human Endometrial Adenocarcinoma (Ishikawa) Cells.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/03//
VL - 72
IS - 1
M3 - Article
SP - 57
EP - 65
PB - Oxford University Press / USA
SN - 10966080
AB - The purpose of this study was to test the hypothesis that acetaminophen would alter an estrogen-regulated process in human cells that express endogenous estrogen receptor α and β (ERα and ERβ). Specifically, the extent to which acetaminophen altered the expression of estrogen-inducible alkaline phosphatase in endometrial adenocarcinoma (Ishikawa) cells and directly interacted with ERβ and ERα was determined. Ishikawa cells were exposed to estradiol and/or to a range of concentrations of acetaminophen for four days, and alkaline phosphatase activity was measured spectrophotometrically. Acetaminophen inhibited both basal and estradiol-induced alkaline phosphatase activity in Ishikawa cells in a concentration-dependent manner. The reduction of Ishikawa cell alkaline phosphatase was not due to direct inhibition of enzyme activity by acetaminophen. Toxic effects of acetaminophen on Ishikawa cells were determined by measuring loss of cellular lactate dehydrogenase to culture medium. High concentrations of acetaminophen (≥0.5 mM) induced lactate dehydrogenase release from cells and reduced the amount of cellular protein in culture dishes, indicating some acetaminophen-induced reduction of alkaline phosphatase activity might be attributed to toxic effects. However, lower concentrations of acetaminophen significantly reduced alkaline phosphatase activity in the absence of detectable toxicity. Acetaminophen also augmented 4-hydroxy-tamoxifen reduction of alkaline phosphatase activity. Competition binding assays with human ERα and ERβ demonstrated 106-fold molar excess acetaminophen did not directly interact significantly with the ligand-binding domain of either receptor. These studies indicate acetaminophen exerts weak antiestrogenic activity in Ishikawa cells without directly binding ERα or ERβ. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endocrine disruptors
KW - Acetaminophen
KW - Estrogen receptors
KW - Alkaline phosphatase
KW - Adenocarcinoma
KW - Cancer cells
KW - acetaminophen
KW - alkaline phosphatase
KW - endocrine disruption
KW - estrogen receptors
KW - Ishikawa cells
N1 - Accession Number: 44406489; Dowdy, Janet 1; Brower, Stacey 1; Miller, Michael R. 1,2,3; Affiliations: 1: Department of Biochemistry and Molecular Pharmacology, West Virginia University Health Sciences Center, P.O. Box 9142, Morgantown, West Virginia 26506-9142; 2: Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, P.O. Box 9142, Morgantown, West Virginia 26506-9142; 3: National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505; Issue Info: Mar2003, Vol. 72 Issue 1, p57; Thesaurus Term: Endocrine disruptors; Subject Term: Acetaminophen; Subject Term: Estrogen receptors; Subject Term: Alkaline phosphatase; Subject Term: Adenocarcinoma; Subject Term: Cancer cells; Author-Supplied Keyword: acetaminophen; Author-Supplied Keyword: alkaline phosphatase; Author-Supplied Keyword: endocrine disruption; Author-Supplied Keyword: estrogen receptors; Author-Supplied Keyword: Ishikawa cells; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfg005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2004-19276-001
AN - 2004-19276-001
AU - Baumohl, Jim
AU - Swartz, James A.
AU - Muck, Randolph D.
T1 - Editors' introduction.
JF - Contemporary Drug Problems: An Interdisciplinary Quarterly
JO - Contemporary Drug Problems: An Interdisciplinary Quarterly
JA - Contemp Drug Probl
Y1 - 2003///Spr-Sum 2003
VL - 30
IS - 1-2
SP - 5
EP - 7
CY - US
PB - Federal Legal Communications
SN - 0091-4509
AD - Baumohl, Jim, Graduate School of Social Work and Social Research, Bryn Mawr College, Bryn Mawr, PA, US, 19010-1697
N1 - Accession Number: 2004-19276-001. Partial author list: First Author & Affiliation: Baumohl, Jim; Graduate School of Social Work and Social Research, Bryn Mawr College, Bryn Mawr, PA, US. Other Publishers: Sage Publications. Release Date: 20041101. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Alcoholism; Drug Addiction; Experience Level; Social Security. Classification: Drug & Alcohol Rehabilitation (3383); Social Structure & Organization (2910). Population: Human (10). Page Count: 3. Issue Publication Date: Spr-Sum 2003.
AB - The set of 16 papers in this issue reports principal findings from the 'SSI Study.' This was a two-year longitudinal inquiry into the lives of almost 1,800 people who in 1996 received Supplemental Security Income benefits by virtue of disabling drug addiction and alcoholism-but whose benefits were jeopardized by the elimination of this impairment category by Congress effective January 1, 1997. The research investigated a variety of outcomes experienced by members of this population during 1997 and 1998. Rather than attempt to summarize this unique study's complex methods or findings by way of introduction, we limit ourselves to the expression of some heartfelt appreciation not apparent in authorship credit or the acknowledgments attached to individual papers. First of all, as the elected editors of the work we'd like to thank the members of the SSI Study Group for their forbearance. Every paper in this issue was reviewed critically by at least two readers not connected with the SSI Study Group. Our panel of referees was assembled to combine methodological and substantive expertise, and its members did a remarkable job of providing thorough, searching, and voluminous comments that greatly improved our work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - supplemental security income
KW - substantive expertise
KW - drug addiction
KW - alcoholism
KW - 2003
KW - Alcoholism
KW - Drug Addiction
KW - Experience Level
KW - Social Security
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19276-001&site=ehost-live&scope=site
UR - jaswartz@uic.edu
UR - jbaumohl@brynmawr.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-02351-003
AN - 2003-02351-003
AU - Gfroerer, Joseph
AU - Penne, Michael
AU - Pemberton, Michael
AU - Folsom, Ralph
T1 - Substance abuse treatment need among older adults in 2020: The impact of the aging baby-boom cohort.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2003/03//
VL - 69
IS - 2
SP - 127
EP - 135
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Gfroerer, Joseph, Office of Applied Studies, Substance Abuse & Mental Health Services Administration, Room 16-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2003-02351-003. PMID: 12609694 Partial author list: First Author & Affiliation: Gfroerer, Joseph; Substance Abuse & Mental Health Administration, Office of Applied Studies, Rockville, MD, US. Release Date: 20030407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Drug Rehabilitation; Health Service Needs. Minor Descriptor: Drug Abuse. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2003.
AB - There is concern that as the baby boom population ages in the US, there will be a substantial increase in the number of older adults needing treatment for substance abuse problems. To address this concern, projections of future treatment need for older adults (defined as age 50 yrs and older) were made. Using data from the National Household Survey on Drug Abuse, regression models including predictors of treatment need in 2000 and 2001 were developed. Treatment need was defined as having an alcohol or illicit drug use disorder in the past year. Regression parameters from these models were applied to the projected 2020 population to obtain estimates of the number of older adults needing treatment in 2020. The number of older adults in need of substance abuse treatment is estimated to increase from 1.7 million in 2000 and 2001 to 4.4 million in 2020. This is due to a 50% increase in the number of older adults and a 70% increase in the rate of treatment need among older adults. The aging baby boom cohort will place increasing demands on the substance abuse treatment system in the next two decades, requiring a shift in focus to address the special needs of an older population of substance abusers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - older adults
KW - Baby Boomers
KW - treatment needs
KW - future treatment
KW - 2003
KW - Aging
KW - Drug Rehabilitation
KW - Health Service Needs
KW - Drug Abuse
KW - 2003
DO - 10.1016/S0376-8716(02)00307-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-02351-003&site=ehost-live&scope=site
UR - jgfroerer@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-06835-009
AN - 2003-06835-009
AU - Simeonov, Peter I.
AU - Hsiao, Hongwei
AU - Dotson, Brian W.
AU - Ammons, Douglas E.
T1 - Control and perception of balance at elevated and sloped surfaces.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 2003///Spr 2003
VL - 45
IS - 1
SP - 136
EP - 147
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
AD - Simeonov, Peter I., 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2003-06835-009. PMID: 12916586 Partial author list: First Author & Affiliation: Simeonov, Peter I.; Protective Technology Branch, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Sage Publications. Release Date: 20030922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Sway Testing; Equilibrium; Occupational Safety; Spatial Orientation (Perception); Working Space. Minor Descriptor: Blue Collar Workers; Human Males. Classification: Motor Processes (2330). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. Page Count: 12. Issue Publication Date: Spr 2003.
AB - Understanding roof-work-related risk of falls and developing low-cost, practical engineering controls for reducing this risk remain in high demand in the construction industry. This study investigated the effects of the roof work environment characteristics of surface slope, height, and visual reference on standing balance in construction workers. The 24 male participants (aged 21-57 yrs) were tested in a laboratory setting at 4 slopes (0°, 18°, 26°, and 34°), 2 heights (0, 3 m), and 2 visual conditions (with and without visual references). Postural sway characteristics were calculated using center of pressure recordings from a force platform. Workers' perceptions of postural sway and instability were also evaluated. The results indicated that slope and height synergistically increased workers' standing postural instability. Workers recognized the individual destabilizing effects of slope and height but did not recognize the synergistic effect of the two. Visual references significantly reduced the destabilizing effects of height and slope. Actual and potential applications of this research include the use of temporary level work surfaces and proximal vertical reference structures as postural instability control measures during roofing work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - balance control
KW - balance perception
KW - standing balance
KW - roof work environment
KW - surface slope
KW - height
KW - visual reference
KW - postural sway
KW - male construction workers
KW - 2003
KW - Body Sway Testing
KW - Equilibrium
KW - Occupational Safety
KW - Spatial Orientation (Perception)
KW - Working Space
KW - Blue Collar Workers
KW - Human Males
KW - 2003
DO - 10.1518/hfes.45.1.136.27232
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-06835-009&site=ehost-live&scope=site
UR - psimeonov@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-01745-014
AN - 2003-01745-014
AU - Buck, Jeffrey A.
AU - Miller, Kay
T1 - Use of nonpsychiatric inpatient care by Medicaid mental health service users.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2003/03//
VL - 54
IS - 3
SP - 300
EP - 300
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Buck, Jeffrey A., Substance Abuse & Mental Health Services Administration, Ctr for Mental Health Services, 5600 Fishers Lane, Room 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2003-01745-014. PMID: 12610235 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; Substance Abuse & Mental Health Services Administration, Ctr for Mental Health Services, Rockville, MD, US. Release Date: 20030331. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hospitalization; Medicaid; Mental Health Services; Psychiatric Patients. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study. References Available: Y. Page Count: 1. Issue Publication Date: Mar, 2003.
AB - Examines the major reasons for nonpsychiatric inpatient stays in the Medicaid mental health service user population. Data are from the Center for Medicare and Medicaid Services' State Medicaid Research Files. A total of 10 states were included. The study group consisted of nonelderly Medicaid recipients who used mental health and substance abuse services in 1995. Across the 10 states, 374,442 mental health service users who met the above criteria were enrolled in Medicaid using 1995. Of this group, 17% had at least 1 inpatient stay of any kind. 12% had at least 1 inpatient stay for a nonpsychiatric reason. In both age groups, pregnancy and childbirth was the most frequently reason for nonpsychiatric inpatient treatment for Medicaid mental health service users, which is also is the most common reason for inpatient stays among all Medicaid enrollees. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nonpsychiatric inpatient care
KW - Medicaid
KW - mental health service users
KW - 2003
KW - Hospitalization
KW - Medicaid
KW - Mental Health Services
KW - Psychiatric Patients
KW - 2003
DO - 10.1176/appi.ps.54.3.300
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-01745-014&site=ehost-live&scope=site
UR - jbuck@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10032-002
AN - 2003-10032-002
AU - Scott, Lionel D. Jr.
T1 - The relation of racial identity and racial socialization to coping with discrimination among African American adolescents.
JF - Journal of Black Studies
JO - Journal of Black Studies
JA - J Black Stud
Y1 - 2003/03//
VL - 33
IS - 4
SP - 520
EP - 538
CY - US
PB - Sage Publications
SN - 0021-9347
SN - 1552-4566
AD - Scott, Lionel D. Jr., Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, Campus Box 1093, 1 Brookings Dr., St. Louis, MO, US, 63146
N1 - Accession Number: 2003-10032-002. Partial author list: First Author & Affiliation: Scott, Lionel D. Jr.; Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO, US. Release Date: 20040816. Correction Date: 20130715. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychology; Blacks; Coping Behavior; Ethnic Identity; Self-Concept. Minor Descriptor: Racial and Ethnic Differences; Social Discrimination; Socialization. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Daily Life Experiences; Racism Experiences Stress Scale; Racism-Related Socialization Influences Scale; Self-Report Coping Scale DOI: 10.1037/t16177-000; Multidimensional Inventory of Black Identity DOI: 10.1037/t03182-000. Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Mar, 2003.
AB - This study purposed to explore whether the strategies used by African American adolescents to cope with perceived discriminatory experiences were related to their racial identity and racial socialization. Results indicated that the degree to which race was central to participant's self-conceptions and identities was unrelated to both approach and avoidance coping strategies. In contrast, the frequency to which participants received socialization messages concerning racism from their parents and/or guardians was related to the use of approach coping strategies but unrelated to avoidance coping strategies. The importance of a more systematic focus on African American adolescent stress and coping is discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - coping strategies
KW - racial socialization
KW - racial identity
KW - African American adolescents
KW - discriminatory experiences
KW - 2003
KW - Adolescent Psychology
KW - Blacks
KW - Coping Behavior
KW - Ethnic Identity
KW - Self-Concept
KW - Racial and Ethnic Differences
KW - Social Discrimination
KW - Socialization
KW - 2003
DO - 10.1177/0021934702250035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10032-002&site=ehost-live&scope=site
UR - lscott@gwbmail.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Fang, Hong
AU - Tong, Weida
AU - Welsh, William J.
AU - Sheehan, Daniel M.
T1 - QSAR models in receptor-mediated effects: the nuclear receptor superfamily
JO - Journal of Molecular Structure: THEOCHEM
JF - Journal of Molecular Structure: THEOCHEM
Y1 - 2003/03/07/
VL - 622
IS - 1/2
M3 - Article
SP - 113
SN - 01661280
AB - The nuclear receptor (NR) superfamily is ligand-dependent transcriptional factors that mediate gene expression in humans and wildlife. These receptor-mediated effects are stimulated and/or inhibited by endogenous cognate ligands for each NR but also by exogenous substances including natural products and synthetic chemicals. The NRs and their ligands have thus attracted broad scientific interest, particularly in the pharmaceutical industry for drug discovery and in toxicology and environmental science for risk assessment as, for example, pertaining to endocrine disrupting chemicals. Besides advancing our fundamental knowledge of NR biology, these scientific efforts are generating relevant biological data on NR ligands particularly with respect to their binding affinities, receptor specificities, and agonist versus antagonist activities. These data from diverse sources serve as input for construction of quantitative structure–activity relationship (QSAR) models and related approaches that employ statistical regression techniques to correlate variations between the biological activities of NR ligands and their calculated structural and physicochemical properties. In this review, we attempt to summarize the substantial body of work in the published literature related to QSAR models for NR ligands, with special emphasis on different computational approaches and specific applications. Special attention is placed on the estrogen receptor, for which the greatest amount of relevant information is known at present. We also describe efforts to create ‘benchmark’ sets of high-quality biological data on NR ligands that may serve as resources for building statistically robust and predictive QSAR models. [Copyright &y& Elsevier]
AB - Copyright of Journal of Molecular Structure: THEOCHEM is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR receptors (Biochemistry)
KW - QSAR (Biochemistry)
KW - Endocrine disrupting chemicals
KW - Estrogen receptor
KW - Nuclear receptors
KW - Quantitative structure–activity relationships
KW - Receptor-mediated effects
N1 - Accession Number: 9143799; Fang, Hong 1 Tong, Weida 1; Email Address: wtong@nctr.fda.gov Welsh, William J. 2 Sheehan, Daniel M. 3; Affiliation: 1: Logicon ROW Sciences, 3900 NCTR Road, MC 910, Jefferson, AR 72079, USA 2: Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine & Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA 3: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), Jefferson, AR 72079, USA; Source Info: Mar2003, Vol. 622 Issue 1/2, p113; Subject Term: NUCLEAR receptors (Biochemistry); Subject Term: QSAR (Biochemistry); Author-Supplied Keyword: Endocrine disrupting chemicals; Author-Supplied Keyword: Estrogen receptor; Author-Supplied Keyword: Nuclear receptors; Author-Supplied Keyword: Quantitative structure–activity relationships; Author-Supplied Keyword: Receptor-mediated effects; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0166-1280(02)00623-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9143799&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lenz, Petra
AU - Bacot, Silvia M.
AU - Frazier-Jessen, Michelle R.
AU - Feldman, Gerald M.
T1 - Nucleoporation of dendritic cells: efficient gene transfer by electroporation into human monocyte-derived dendritic cells11 Disclaimer: The opinions expressed in this article are those of the author and not necessarily those of the Food and Drug Administration or the U.S. Government. The publication of this article should not be construed as an endorsement or approval of either the product or the company.p<0.05 ) D-values at 100 °C than unstressed spores. Proteins with epitopic and size similarity to Escherichia coli GroEL and Bacillus subtilis small acid-soluble protein, SspC, were present in spores. However, heat shock treated spores did not appear to significantly increase expression of these proteins. Acquired thermotolerance is of substantial practical importance to food processors and should provide useful information for designing thermal treatments to eliminate C. perfringens spores in ready-to-eat foods. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BEEF
KW - CLOSTRIDIUM perfringens
KW - Clostridium perfringens
KW - Heat resistance
KW - Heat shock
KW - Thermotolerance
N1 - Accession Number: 8901358; Juneja, Vijay K. 1; Email Address: vjuneja@arserrc.gov Novak, John S. 1 Huang, Lihan 1 Eblen, Brian S. 2; Affiliation: 1: US Department of Agriculture,1 Mention of brand or firm name does not constitute an endorsement by the US Department of Agriculture above others of a similar nature not mentioned.☆ Presented in part at the 39th annual meeting of the Society of Toxicology, March 19–23, 2000.RS,RS -bis(p-tolylsulfinyl)ethane, RS,RS -BTSE. All complexes revealed S-ligation to the metal with an expected contraction of the sulfinyl-oxygen bond length when compared to free sulfoxide. The presented data serve to illustrate three attractive, yet unexplored, aspects of the bis(sulfoxide) bidentate ligand: (i) bidentate sulfoxide ligands, when chelated to a metal, give rise to complexes that are pseudo-C2 symmetric in terms of both sterics and electronics, (ii) the sulfoxides, unlike typical N-, P-, and O-based ligands, present the coordination sphere with a significant amount of steric and electronic mismatch, and (iii) the data support the fact that sulfoxides are moderate σ-donors and good-to-excellent π-acceptors – an aspect that should afford such metal chelates with a wide degree of reactivity. Finally, X-ray crystallographic experiments, coupled with an extensive CCDC search, provide an opportunity to establish the following ligand-ranking scheme for bidentate ligands spanned by an ethylene bridge, R2N–, based on the trans influence of chloride salts of Pt(II). [Copyright &y& Elsevier]
AB - Copyright of Inorganic Chemistry Communications is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHELATES
KW - METAL complexes
N1 - Accession Number: 9500193; Evans, Daniel R. 1; Email Address: drevans37@hotmail.com Huang, Mingsheng 1 Michael Seganish, W. 1 Fettinger, James C. 1 Williams, Tracie L. 2; Affiliation: 1: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA 2: Center for Food Safety and Nutrition, Food and Drug Administration, College Park, MD 20741, USA; Source Info: May2003, Vol. 6 Issue 5, p462; Subject Term: CHELATES; Subject Term: METAL complexes; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S1387-7003(03)00004-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9500193&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schatzel, Steven J.
AU - Stewart, Brian W.
T1 - Rare earth element sources and modification in the Lower Kittanning coal bed, Pennsylvania: implications for the origin of coal mineral matter and rare earth element exposure in underground mines
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2003/05//
VL - 54
IS - 3/4
M3 - Article
SP - 223
SN - 01665162
AB - In this study, we examine the variations in rare earth elements (REE) from the Lower Kittanning coal bed of eastern Ohio and western Pennsylvania, USA, in an attempt to understand the factors that control mineral matter deposition and modification in coal, and to evaluate possible REE mixed exposure hazards facing underground mine workers. The results of this study suggest that the Lower Kittanning coal mineral matter is derived primarily from a clastic source similar to that of the shale overburden. While highly charged cations like silicon, aluminum, and titanium remained relatively immobile within the coal mineral matter, iron (primarily as pyrite) was added from nonclastic sources, either during deposition of the coal mire vegetation or subsequent to burial. Other mobile cations (e.g., alkali and alkaline earth elements) appear to have been added to and/or leached from the originally deposited clastic mineral matter. Most of the sulfur in the Lower Kittanning coal bed is bound as FeS2 in the mineral matter, but a majority of samples contain a small excess of S that is most likely organically bound.In general, the total rare earth element content (TREE) in coal ash is greater than that in the shale overburden. If the primary source of mineral matter is the same as that for the overlying shale, then REE must have been enriched in the coal mineral matter subsequent to deposition. The total rare earth element content of Lower Kittanning coals correlates strongly with Si concentration ([TREE]≈0.0024 [Si]), which provides a threshold for evaluating possible mixed exposure health effects. Chondrite-normalized REE patterns reveal a shale-like light rare earth element (LREE) enrichment for the coal, similar to that of the shale overburden, again suggesting a primarily clastic REE source. However, when normalized to the shale overburden, most of the coal ash samples display a small but distinct heavy rare earth element (HREE) enrichment. We surmise that the HREE were added and/or preferentially retained during epigenesis, possibly associated with groundwater flow through the coal unit, but not necessarily in close association with the addition of iron. At least some of the “excess” HREE could be organically bound within the Lower Kittanning coal. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RARE earth industry
KW - COAL
KW - Coal
KW - Geochemistry
KW - Lower Kittanning
KW - Rare earth elements
KW - Trace elements
N1 - Accession Number: 9951465; Schatzel, Steven J. 1,2; Email Address: zia6@cdc.gov Stewart, Brian W. 2; Email Address: bstewart@pitt.edu; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh, PA 15236, USA 2: Department of Geology and Planetary Science, University of Pittsburgh, Pittsburgh, PA 15260, USA; Source Info: May2003, Vol. 54 Issue 3/4, p223; Subject Term: RARE earth industry; Subject Term: COAL; Author-Supplied Keyword: Coal; Author-Supplied Keyword: Geochemistry; Author-Supplied Keyword: Lower Kittanning; Author-Supplied Keyword: Rare earth elements; Author-Supplied Keyword: Trace elements; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 29p; Document Type: Article
L3 - 10.1016/S0166-5162(03)00038-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9951465&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106865185
T1 - Clinical pharmacology of topiramate versus lamotrigine versus phenobarbital: comparison of efficacy and side effects using odds ratios.
AU - Lathers CM
AU - Schraeder PL
AU - Claycamp HG
Y1 - 2003/05//
N1 - Accession Number: 106865185. Language: English. Entry Date: 20030905. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Anticonvulsants -- Adverse Effects
KW - Anticonvulsants -- Pharmacodynamics
KW - Comparative Studies
KW - Economics, Pharmaceutical
KW - Lamotrigine -- Pharmacodynamics
KW - Odds Ratio
KW - Phenobarbital -- Pharmacodynamics
KW - Human
SP - 491
EP - 503
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 43
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Clinical pharmacologists, neurologists, internists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug (AED) when determining which drug is best for a given patient. The first purpose of this paper is to address whether the 'new' AEDs have advantages over the 'old' drugs. The second purpose is to teach those interested in clinical pharmacology about the use of Web-based information access to answer a neurology/clinical pharmacology problem: to compare the efficacy and side effects of topiramate versus lamotrigine versus phenobarbital using odds ratios. Cost of all three AEDs was also compared. A number of new AEDs, including topiramate and lamotrigine, have been developed for chronic focal and secondarily generalized epileptic seizures. Efficacy of these drugs as anticonvulsants does not seem to be superior to that of traditional anticonvulsants such as phenobarbital. However, the advantage of the new drugs is a different spectrum of possible adverse events. Newer AEDs may or may not induce sedation and may minimize noncompliance by reducing side effects of lethargy and cognitive impairment. The difficulty in achieving therapeutic dosage because of side effects makes one consider whether these agents are 'better' than the oldest and most side effect-prone AED, phenobarbital. The new AEDs have less frequent interactions, leading to improved tolerability with comedication. This exercise compares two 'new' AEDs, topiramate and lamotrigine, with phenobarbital by evaluating efficacies and side effects using relative odds ratios, a method commonly used in drug development research. Development of new algorithms and/or new knowledge will bring beneficial tools to all clinical pharmacologists.
SN - 0091-2700
AD - Center for Veterinary Medicine, US Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855
U2 - PMID: 12751270.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106865185&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Marie Yeung, P.S.
AU - DePaola, A.
AU - Kaysner, C.A.
AU - Boor, K.J.
T1 - A PCR Assay for Specific Detection of the Pandemic Vibrio parahaemolyticus O3:K6 Clone from Shellfish.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2003/05//
VL - 68
IS - 4
M3 - Article
SP - 1459
EP - 1466
SN - 00221147
AB - bstract : The current standard method for identifying Vibrio parahaemolyticus serotype O3:K6, an emerging pathogen with apparent enhanced virulence characteristics, typically takes 4 to 6 d to complete and requires serotyping. To provide a more rapid strategy, we optimized a polymerase chain reaction (PCR)-based assay for specific detection of V. parahaemolyticus O3:K6. Of 78 V. parahaemolyticus isolates and other related species; only strains classified into the V. parahaemolyticus O3:K6 clonal group ( n= 39) showed positive results in the PCR assay. The assay detected 2.3 cells/PCR reaction and 310 cells/g using bacterial cultures and inoculated oyster samples, respectively. Sensitive and specific detection of V. parahaemolyticus O3:K6 was possible following a 6-h enrichment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO parahaemolyticus
KW - GENETICS
KW - VIRUS diseases
KW - RESEARCH
KW - POLYMERASE chain reaction
KW - BACTERIAL cultures
KW - PATHOGENIC microorganisms
N1 - Accession Number: 63141299; Marie Yeung, P.S. 1; Email Address: kjb4@cornell.edu DePaola, A. 1; Email Address: kjb4@cornell.edu Kaysner, C.A. 1; Email Address: kjb4@cornell.edu Boor, K.J. 1; Email Address: kjb4@cornell.edu; Affiliation: 1: Authors Marie Yeung and Boor are with the Dept. of Food Science, Cornell Univ., Ithaca, NY 14853. Author DePaola is with the Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, AL 36528. Author Kaysner is with Seafood Products Research Center, Food and Drug Administration, Bothell, WA 98021. Direct inquiries to author Boor (E-mail: ).; Source Info: May2003, Vol. 68 Issue 4, p1459; Subject Term: VIBRIO parahaemolyticus; Subject Term: GENETICS; Subject Term: VIRUS diseases; Subject Term: RESEARCH; Subject Term: POLYMERASE chain reaction; Subject Term: BACTERIAL cultures; Subject Term: PATHOGENIC microorganisms; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1365-2621.2003.tb09667.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=63141299&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snellings, S.L.
AU - Takenaka, N.E.
AU - Kim-Hayes, Y.
AU - Miller, D.W.
T1 - Rapid Colorimetric Method to Detect Indole in Shrimp with Gas Chromatography Mass Spectrometry Confirmation.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2003/05//
VL - 68
IS - 4
M3 - Article
SP - 1548
EP - 1553
SN - 00221147
AB - BSTRACT : With increased public concern over the freshness and quality of seafood, more pressure is being applied to the industry to provide better products in the market place. Simple, fast, and inexpensive tests are needed to assess seafood quality. Seafood decomposition can be characterized by biogenic amine formation, such as the formation of indole in shrimp. We have developed a rapid colorimetric method using 4-(dimethylamino) benzaldehyde method that detects indole in decomposing shrimp. This method, as well as the confirmatory gas chromatography/mass spectrometry (GC/MS) method, is centered on a simple toluene extraction technique that recovers indole with high efficiency. Excellent agreement was obtained between the colorimetric and GC/MS quantitative results for shrimp decomposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEAFOOD
KW - RESEARCH
KW - FOOD -- Quality -- Research
KW - BIOGENIC amines
KW - INDOLE
KW - SHRIMPS
KW - DECOMPOSITION (Chemistry)
N1 - Accession Number: 63141260; Snellings, S.L. 1; Email Address: dmiller@nctr.fda.gov Takenaka, N.E. 1; Email Address: dmiller@nctr.fda.gov Kim-Hayes, Y. 1; Email Address: dmiller@nctr.fda.gov Miller, D.W. 1; Email Address: dmiller@nctr.fda.gov; Affiliation: 1: Authors Snellings and Miller are with the Division of Chemistry, National Center for Toxicological Research, Jefferson Laboratories of the FDA, 3900 NCTR Road, Jefferson, AR, 72079. Author Takenaka is with the Brown & Williamson Tobacco Corp., 2600Weaver Rd., Macon, GA 31217. Author Kim-Hayes is with Magellan Laboratories Inc., 160 Magellan Lab Court. Morrisville, NC 27560. Direct inquiries to author Miller (E-mail: ).; Source Info: May2003, Vol. 68 Issue 4, p1548; Subject Term: SEAFOOD; Subject Term: RESEARCH; Subject Term: FOOD -- Quality -- Research; Subject Term: BIOGENIC amines; Subject Term: INDOLE; Subject Term: SHRIMPS; Subject Term: DECOMPOSITION (Chemistry); NAICS/Industry Codes: 445220 Fish and Seafood Markets; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1365-2621.2003.tb09682.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=63141260&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106848496
T1 - SSI enrollee's health care in TennCare.
AU - Hill SC
AU - Wooldridge J
Y1 - 2003/05//5/1/2003
N1 - Accession Number: 106848496. Language: English. Entry Date: 20030711. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. NLM UID: 9103800.
KW - Medicaid -- Tennessee
KW - Managed Care Programs -- Tennessee
KW - Disabled -- Tennessee
KW - Health Services Accessibility -- Tennessee
KW - Tennessee
KW - Economic and Social Security
KW - Health Services -- Utilization
KW - Surveys
KW - Data Collection, Computer Assisted
KW - Urban Areas
KW - Consumer Satisfaction
KW - Referral and Consultation
KW - Capitation Fee
KW - Adult
KW - Child
KW - Chi Square Test
KW - Health Status
KW - Functional Status
KW - Descriptive Statistics
KW - Health Services Needs and Demand
KW - Human
SP - 229
EP - 243
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 14
IS - 2
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - How well does TennCare, Tennessee's Medicaid managed care program, meet the needs of blind/disabled Supplemental Security Income (SSI) enrollees? People with disabilities have extensive health care needs and greater barriers to accessing care, so efforts to reduce service use may decrease their health and independence. On the other hand, managed care plans may better coordinate care. Computer-assisted telephone surveys of urban SSI and other urban TennCare enrollees were conducted to assess these issues. SSI enrollees in TennCare had mixed experiences, and they faced problems in areas particularly important to people with disabilities. Relative to other TennCare enrollees, SSI enrollees had similar or slightly worse access to care and satisfaction. A significant minority of SSI enrollees reported unmet needs for care, such as not getting referrals to specialists, prescription drugs, and special medical equipment. Lack of care coordination was a problem for some SSI enrollees.
SN - 1049-2089
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 12739302.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106848496&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yeh, L.-H.
AU - Alayash, A. I.
T1 - Redox side reactions of haemoglobin and cell signalling mechanisms1.
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
Y1 - 2003/05//
VL - 253
IS - 5
M3 - Article
SP - 518
EP - 526
PB - Wiley-Blackwell
SN - 09546820
AB - Abstract. Yeh L-H, Alayash AI (Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA). Redox side reactions of haemoglobin and cell signalling mechanisms (Minisymposium). J Intern Med 2003; 253: 518–526. Cell-free chemically modified or recombinant haemoglobins developed as oxygen therapeutics are designed to correct oxygen deficit caused by ischaemia in a variety of clinical settings. Oxidative processes, which are in some cases enhanced when modifications are introduced that lower oxygen affinity, can limit the safety of these proteins. Direct cytotoxic effects associated with haemoglobins have been ascribed to the redox reactions between haemoglobin and biological peroxides [i.e. hydrogen peroxide (H2 O2 ), lipid peroxides (LOOH) and peroxynitrite (ONOO– )]. Biochemical changes at the cellular, tissue and organ levels have been documented to occur in response to haemoglobin oxidative reactions. These peroxides have been implicated as regulators of redox sensitive cell signalling pathways. The effects of reactions between haemoglobin and biologically relevant peroxides may be more subtle than oxidative damage and may thus involve perturbation of redox sensitive signalling pathways. In this review, a brief outline of the role of cell-free haemoglobin in oxidative and cell-signalling pathways and the implications of these reactions on the safety and efficacy evaluation of haemoglobin-based oxygen carries are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Internal Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANOXEMIA
KW - ISCHEMIA
KW - HEMOGLOBIN
KW - TREATMENT
KW - blood substitutes
KW - haemoglobin
KW - hypoxia-inducible factor
KW - signalling pathways
N1 - Accession Number: 9551993; Yeh, L.-H. 1 Alayash, A. I. 1; Affiliation: 1: From the Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: May2003, Vol. 253 Issue 5, p518; Subject Term: ANOXEMIA; Subject Term: ISCHEMIA; Subject Term: HEMOGLOBIN; Subject Term: TREATMENT; Author-Supplied Keyword: blood substitutes; Author-Supplied Keyword: haemoglobin; Author-Supplied Keyword: hypoxia-inducible factor; Author-Supplied Keyword: signalling pathways; Number of Pages: 9p; Document Type: Article
L3 - 10.1046/j.1365-2796.2003.01152.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9551993&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blackstone, George M.
AU - Nordstrom, Jessica L.
AU - Vickery, Michael C.L.
AU - Bowen, Michael D.
AU - Meyer, Richard F.
AU - DePaola, Angelo
T1 - Detection of pathogenic Vibrio parahaemolyticus in oyster enrichments by real time PCR
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2003/05//
VL - 53
IS - 2
M3 - Article
SP - 149
SN - 01677012
AB - A real time polymerase chain reaction (PCR) assay was developed and evaluated to detect the presence of the thermostable direct hemolysin gene (tdh), a current marker of pathogenicity in Vibrio parahaemolyticus. The real time PCR fluorogenic probe and primer set was tested against a panel of numerous strains from 13 different bacterial species. Only V. parahaemolyticus strains possessing the tdh gene generated a fluorescent signal, and no cross-reaction was observed with tdh negative Vibrio or non-Vibrio spp. The assay detected a single colony forming unit (CFU) per reaction of a pure culture template. This sensitivity was achieved when the same template amount per reaction was tested in the presence of 2.5 μl of a tdh negative oyster:APW enrichment (oyster homogenate enriched in alkaline peptone water overnight at 35 °C). This real time technique was used to test 131 oyster:APW enrichments from an environmental survey of Alabama oysters collected between March 1999 and September 2000. The results were compared to those previously obtained using a streak plate procedure for culture isolation from the oyster:APW enrichment combined with use of a non-radioactive DNA probe for detection of the tdh gene. Real time PCR detected tdh in 61 samples, whereas the streak plate/probe method detected tdh in 15 samples. Only 24 h was required for detection of pathogenic V. parahaemolyticus in oyster:APW enrichments by real time PCR, whereas the streak plate/probe method required 3 days and was more resource intensive. This study demonstrated that real time PCR is a rapid and reliable technique for detecting V. parahaemolyticus possessing the tdh gene in pure cultures and in oyster enrichments. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - VIBRIO
KW - Oyster
KW - Real time PCR
KW - Vibrio parahaemolyticus
N1 - Accession Number: 9342716; Blackstone, George M. 1; Email Address: gblackstone@cfsan.fda.gov Nordstrom, Jessica L. 1 Vickery, Michael C.L. 1 Bowen, Michael D. 2 Meyer, Richard F. 2 DePaola, Angelo 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Post Office Box 158, Dauphin Island, AL 36528-0158, USA 2: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; Source Info: May2003, Vol. 53 Issue 2, p149; Subject Term: POLYMERASE chain reaction; Subject Term: VIBRIO; Author-Supplied Keyword: Oyster; Author-Supplied Keyword: Real time PCR; Author-Supplied Keyword: Vibrio parahaemolyticus; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0167-7012(03)00020-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9342716&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bethem, Robert
AU - Boison, Joe
AU - Gale, Jane
AU - Heller, David
AU - Lehotay, Steven
AU - Loo, Joseph
AU - Musser, Steven
AU - Price, Phil
AU - Stein, Stephen
T1 - Establishing the fitness for purpose of mass spectrometric methods
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2003/05//
VL - 14
IS - 5
M3 - Article
SP - 528
SN - 10440305
AB - This report is submitted by a working group sponsored by the ASMS Measurements and Standards Committee. The group responded to a 1998 opinion piece dealing with mass spectrometry in trace analysis (Bethem, R. A.; Boyd, R. K. J. Am. Soc. Mass Spectrom. 1998, 9, 643–648) which proposed that the concept of fitness for purpose addresses the needs of a wide range of analytical problems. There is a need to define fitness for purpose within the current context of mass spectrometry and to recommend processes for developing and evaluating methods according to suitability for a particular purpose. The key element in our proposal is for the interested parties to define in advance the acceptable degree of measurement uncertainty and the desired degree of identification confidence. These choices can serve as guideposts during method development and targets for retrospective evaluation of methods. A series of more detailed recommendations are derived from basic principles and also from reviews of current practice. This report highlights some areas where consensus is evident, but also revealed the need for further work in other areas. The recommendations are aimed primarily for the laboratory analyst but we hope they will be accessible to the non-scientist as well. Our goal was to provide a framework that can support informed decisions and foster discussion of the issues, because ultimately it is the responsibility of the analyst to make choices, provide supporting data, and interpret results according to scientific principles and qualified judgment. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRACE analysis
KW - MASS spectrometry
N1 - Accession Number: 9712692; Bethem, Robert 1 Boison, Joe 2 Gale, Jane 3 Heller, David 4; Email Address: dheller@cvm.fda.gov Lehotay, Steven 5 Loo, Joseph 6 Musser, Steven 7 Price, Phil 8 Stein, Stephen 9; Affiliation: 1: Alta Analytical Laboratory, El Dorado Hills, California, USA 2: Canadian Food Inspection Agency, Saskatoon, Saskatchewan, Canada 3: Bristol-Myers Squibb, New Brunswick, New Jersey, USA 4: FDA Center for Veterinary Medicine, Laurel, Maryland, USA 5: USDA/ARS Eastern Regional Research Center, Wyndmoor, Pennsylvania, USA 6: Pfizer Global Research and Development, Ann Arbor, Michigan, USA 7: FDA Center for Food Safety and Applied Nutrition, Washington, D.C., USA 8: Dow Chemical, South Charleston, West Virginia, USA 9: National Institute of Standards and Technology, Gaithersburg, Maryland, USA; Source Info: May2003, Vol. 14 Issue 5, p528; Subject Term: TRACE analysis; Subject Term: MASS spectrometry; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/S1044-0305(03)00137-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9712692&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106837021
T1 - Device safety. Can you stomach it? Abdominal muscle stimulators.
AU - Todd JF
Y1 - 2003/05//
N1 - Accession Number: 106837021. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Electric Stimulation -- Equipment and Supplies
KW - Equipment Safety
KW - Muscle Contraction
KW - Pacemaker, Artificial -- Adverse Effects
KW - Electric Stimulation -- Contraindications
KW - Female
KW - Pregnancy
SP - 27
EP - 27
JO - Nursing
JF - Nursing
JA - NURSING
VL - 33
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food an Drug Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106837021&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roth, Ted M.
AU - Gustilo-Ashby, Tara
AU - Barber, Matthew D.
AU - Myers, Evan R.
T1 - Effects of race and clinical factors on short-term outcomes of abdominal myomectomy
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2003/05//
VL - 101
IS - 5 part 1
M3 - Article
SP - 881
SN - 00297844
AB - : ObjectiveTo estimate the effects of race and preoperative uterine anatomy on complication rates after myomectomy.: MethodsA total of 239 abdominal myomectomies were performed at Duke University Medical Center from July 1992 through June 1998. Charts were abstracted using standardized forms. We assessed patient characteristics, surgical indications, preoperative hematocrit, and operative findings. Outcomes were defined as any complication, including transfusion.: ResultsThe population (n = 225) was 53% black and 47% white. The mean body mass index was 26. Fourteen percent had comorbidities. Twenty percent required transfusion. Black women were found to be more likely to have uteri with more than four leiomyomata and less likely to have only one leiomyoma (P = .001). Black women were 2.48 times more likely to have a complication (P < .006). Race was no longer a significant predictor for complications (odds ratio [OR] 1.36, 95% confidence interval [CI] 0.56, 3.15) after adjustment for uterine size (OR 1.86, 95% CI 1.3, 2.67), number of leiomyomata (OR 1.83, 95% CI 1.1, 3.14), and comorbidities (OR 2.77, 95% CI 1.1, 7.69). A similar pattern was seen for blood transfusion.: ConclusionBlack women undergoing myomectomy are more than twice as likely to have in-hospital complication or blood transfusion than white women. This is largely attributable to differences in uterine size and leiomyoma number. Research is needed to explore why black women are more likely to have larger and more numerous leiomyomata at the time of presentation for surgery. [Copyright &y& Elsevier]
AB - Copyright of Obstetrics & Gynecology is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOMECTOMY
KW - UTERUS
N1 - Accession Number: 9656965; Roth, Ted M. 1; Email Address: timbukted@yahoo.com Gustilo-Ashby, Tara 2 Barber, Matthew D. 3 Myers, Evan R. 4; Affiliation: 1: Division of Gynecology, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA 2: Indian Health Service, Chinle, New Mexico, USA 3: Division of Urogynecology, Department of Obstetrics and Gynecology, The Cleveland Clinic Hospitals, Cleveland, Ohio, USA 4: Division of Clinical and Epidemiological Research, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA; Source Info: May2003, Vol. 101 Issue 5 part 1, p881; Subject Term: MYOMECTOMY; Subject Term: UTERUS; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S0029-7844(03)00015-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9656965&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coté, C. J.
AU - Alexander, J.
T1 - Drug development for children: the past, the present, hope for the future1.
JO - Paediatric Anaesthesia
JF - Paediatric Anaesthesia
Y1 - 2003/05//
VL - 13
IS - 4
M3 - Article
SP - 279
EP - 282
PB - Wiley-Blackwell
SN - 11555645
AB - Comments on the evolutionary process of drug development for children. Dilemma of physicians regarding the administration of unapproved drugs to children; Dependence of drug approving agencies on the data supplied by drug manufacturers; Disappointment of generic drug industry over the deprivation of access to drugs coming off-patients.
KW - DRUG development
KW - CHILDREN
N1 - Accession Number: 9954992; Coté, C. J. 1 Alexander, J. 2; Affiliation: 1: Professor of Anesthesiology and Pediatrics, The Feinberg School of Medicine, Northwestern University, Children's Memorial Hospital, Chicago, IL, USA and 2: Division of Anti-Infective Drug Products, Food and Drug Administration, Corporate Boulevard, Rockville, MD, USA; Source Info: May2003, Vol. 13 Issue 4, p279; Subject Term: DRUG development; Subject Term: CHILDREN; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1046/j.1460-9592.2003.01071.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9954992&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106592493
T1 - Datapoints. Mental health services in employee assistance programs, 2001.
AU - Teich JL
AU - Buck JA
A2 - Pincus HA
A2 - Tanielian TL
Y1 - 2003/05//
N1 - Accession Number: 106592493. Language: English. Entry Date: 20050311. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Employee Assistance Programs
KW - Mental Health Services
KW - Occupational Health Services
KW - Descriptive Statistics
KW - Human
SP - 611
EP - 611
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 54
IS - 5
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Office of Organization and Financing of the Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 15-87, Rockville, MD 20857; jteich@samhsa.gov
U2 - PMID: 12719490.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Uribarri, Jaime
AU - Calvo, Mona S.
T1 - Hidden Sources of Phosphorus in the Typical American Diet: Does it Matter in Nephrology?
JO - Seminars in Dialysis
JF - Seminars in Dialysis
Y1 - 2003/05//
VL - 16
IS - 3
M3 - Article
SP - 186
EP - 188
PB - Wiley-Blackwell
SN - 08940959
AB - ABSTRACT Elevated serum phosphorus is a major, preventable etiologic factor associated with the increased cardiovascular morbidity and mortality of dialysis patients. An important determinant of serum phosphorus is the dietary intake of this mineral; this makes dietary restriction of phosphorus a cornerstone for the prevention and treatment of hyperphosphatemia. The average daily dietary intake of phosphorus is about 1550 mg for males and 1000 mg for females. In general, foods high in protein are also high in phosphorus. These figures, however, are changing as phosphates are currently being added to a large number of processed foods including meats, cheeses, dressings, beverages, and bakery products. As a result, and depending on the food choices, such additives may increase the phosphorus intake by as a much as 1 g/day. Moreover, nutrient composition tables usually do not include the phosphorus from these additives, resulting in an underestimate of the dietary intake of phosphorus in our patients. Our goal is to convey an understanding of the phosphorus content of the current American diet to better equip nephrologists in their attempt to control hyperphosphatemia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Seminars in Dialysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHORUS in the body
KW - NEPHROLOGY
KW - DIET
KW - UNITED States
N1 - Accession Number: 9732554; Uribarri, Jaime 1 Calvo, Mona S. 2; Affiliation: 1: Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, and 2: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C.; Source Info: May2003, Vol. 16 Issue 3, p186; Subject Term: PHOSPHORUS in the body; Subject Term: NEPHROLOGY; Subject Term: DIET; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1525-139X.2003.16037.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9732554&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fedorowicz, A.
AU - Koll, A.
AU - Mavri, J.
T1 - Molecular dynamics study of the tautomeric equilibrium in the 4-nitro- and 2,4,6-trichloro derivatives of 2-(N,N-dialkyloaminomethyl)phenol.
JO - Theoretical Chemistry Accounts: Theory, Computation, & Modeling
JF - Theoretical Chemistry Accounts: Theory, Computation, & Modeling
Y1 - 2003/05//
VL - 109
IS - 4
M3 - Article
SP - 220
EP - 228
PB - Springer Science & Business Media B.V.
SN - 1432881X
AB - Molecular dynamics thermodynamic integration (MDTI) method and quantum chemical calculations at the density functional theory B3LYP 6-31+(d,p) level, which included the Tomasi model of the solvent reaction field, were applied to study the tautomeric equilibrium of Mannich base in methanol solution. The values obtained for the free-energy difference are in good agreement with experimental data. However, the results from quantum mechanical calculations were not as good as the results of MDTI simulations owing to inappropriate treatment of intermolecular hydrogen bonds between the solute molecule and the first shell of solvent molecules in the Tomasi model of the solvent reaction field. The radial distribution functions between solute atoms and solvent atoms confirmed the formation of hydrogen bonds between the solute molecule and surrounding methanol molecules and indicated that the zwitterionic form is associated more with an organized solvent structure at the level of the first solvation shell than is the molecular form. [ABSTRACT FROM AUTHOR]
AB - Copyright of Theoretical Chemistry Accounts: Theory, Computation, & Modeling is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR dynamics
KW - TAUTOMERISM
KW - ISOMERISM
KW - MESOMERISM
KW - PHYSICAL & theoretical chemistry
KW - DENSITY functionals
KW - Mannich base
KW - Molecular dynamics
KW - Solvent effect
KW - Tautomerism
KW - Thermodynamic integration
N1 - Accession Number: 16984204; Fedorowicz, A. 1; Email Address: ajf4@cdc.gov Koll, A. 2 Mavri, J. 3; Affiliation: 1: National Institute of Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 , Wroclaw, Poland 3: National Institute of Chemistry, Hajdrihova 19, Ljubljana , 1000, Slovenia; Source Info: May2003, Vol. 109 Issue 4, p220; Subject Term: MOLECULAR dynamics; Subject Term: TAUTOMERISM; Subject Term: ISOMERISM; Subject Term: MESOMERISM; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: DENSITY functionals; Author-Supplied Keyword: Mannich base; Author-Supplied Keyword: Molecular dynamics; Author-Supplied Keyword: Solvent effect; Author-Supplied Keyword: Tautomerism; Author-Supplied Keyword: Thermodynamic integration; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s00214-002-0401-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16984204&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ladics, G. S.
AU - Holsapple, M. P.
AU - Astwood, J. D.
AU - Kimber, I.
AU - Knippels, L. M. J.
AU - Helm, R. M.
AU - Dong, W.
T1 - Workshop Overview: Approaches to the Assessment of the Allergenic Potential of Food from Genetically Modified Crops.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/05//
VL - 73
IS - 1
M3 - Article
SP - 8
EP - 16
PB - Oxford University Press / USA
SN - 10966080
AB - There is a need to assess the safety of foods deriving from genetically modified (GM) crops, including the allergenic potential of novel gene products. Presently, there is no single in vitro or in vivo model that has been validated for the identification or characterization of potential food allergens. Instead, the evaluation focuses on risk factors such as source of the gene (i.e., allergenic vs. nonallergenic sources), physicochemical and genetic comparisons to known allergens, and exposure assessments. The purpose of this workshop was to gather together researchers working on various strategies for assessing protein allergenicity: (1) to describe the current state of knowledge and progress that has been made in the development and evaluation of appropriate testing strategies and (2) to identify critical issues that must now be addressed. This overview begins with a consideration of the current issues involved in assessing the allergenicity of GM foods. The second section presents information on in vitro models of digestibility, bioinformatics, and risk assessment in the context of clinical prevention and management of food allergy. Data on rodent models are presented in the next two sections. Finally, nonrodent models for assessing protein allergenicity are discussed. Collectively, these studies indicate that significant progress has been made in developing testing strategies. However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transgenic plants
KW - Food allergy
KW - Genetic toxicology
KW - Conferences & conventions
KW - Genetically modified foods -- Congresses
N1 - Accession Number: 20606159; Ladics, G. S. 1; Email Address: gregory.s.ladics@usa.dupont.com; Holsapple, M. P. 2; Astwood, J. D. 3; Kimber, I. 4; Knippels, L. M. J. 5; Helm, R. M. 6; Dong, W. 7; Affiliations: 1: The DuPont Co., Haskell Laboratory, Newark, Delaware; 2: ILSI Health and Environmental Sciences Institute, Washington, DC; 3: Monsanto Co., Product Safety Center, St. Louis, Missouri; 4: Syngenta Central Toxicology Laboratory, Cheshire, United Kingdom; 5: TNO Nutrition and Food Research, Zeist, The Netherlands; 6: University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas; 7: U. S. Food and Drug Administration, Washington, DC; Issue Info: May2003, Vol. 73 Issue 1, p8; Thesaurus Term: Transgenic plants; Thesaurus Term: Food allergy; Thesaurus Term: Genetic toxicology; Subject Term: Conferences & conventions; Subject Term: Genetically modified foods -- Congresses; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/toxsci/kfg055
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Saxena, R. K.
AU - Saxena, Q. B.
AU - Weissman, D. N.
AU - Simpson, J. P.
AU - Bledsoe, T. A.
AU - Lewis, D. M.
T1 - Effect of Diesel Exhaust Particulate on Bacillus Calmette-Guerin Lung Infection in Mice and Attendant Changes in Lung Interstitial Lymphoid Subpopulations and IFN&ggr; Response.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/05//
VL - 73
IS - 1
M3 - Article
SP - 66
EP - 71
PB - Oxford University Press / USA
SN - 10966080
AB - The effect of exposure to diesel exhaust particulate (DEP) on bacillus Calmette-Guerin (BCG) lung infection in mice was studied. C57Bl/6J female mice were infected with BCG (2.5 × 104 bacteria/mouse) by intrapulmonary instillation, with or without coadministration of DEP (100 μg/mouse). Five weeks later, mice exposed to DEP + BCG had about a four-fold higher BCG load in the lungs than mice exposed only to BCG (p < 0.05). DEP treatment alone had no effect on the total number of lung lymphocytes or numbers of T, B, or NK cells recovered from lungs. In contrast, BCG infection significantly increased (p< 0.05) recovery levels of all types of lymphocytes from lungs. Coexposure to DEP + BCG further increased the recovery of lymphocytes from lungs of BCG-infected mice. The pulmonary lymphocyte subpopulation expressing the greatest levels of mRNA for IFN&ggr; after BCG infection was CD4+ T cells. Expression levels were similar in mice exposed to BCG or BCG + DEP and were elevated as compared to noninfected mice and mice treated with DEP alone. Recovery of IFN&ggr;-secreting lymphocytes and IFN&ggr;-secreting T cells was significantly higher (p < 0.05) from lungs of BCG-infected mice as compared to control or DEP-exposed mice. BCG and BCG + DEP groups of mice did not differ significantly in the numbers of IFN&ggr;-secreting lymphocytes in lungs. Taken together, these results indicated that coexposure to DEP + BCG did not significantly affect the level of IFN&ggr; response of mice to BCG infection. However, DEP treatment was found to inhibit IFN&ggr;-induced nitric oxide (NO) production by mouse alveolar macrophages in vitro. Our results indicate that DEP exposure did not alter the IFN&ggr; response to BCG infection, but reduced responsiveness of alveolar macrophages to IFN&ggr;. Reduced sensitivity of DEP-exposed alveolar macrophages to IFN&ggr; may contribute to a greater load of BCG in the lungs of BCG-infected mice given DEP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Diesel motor exhaust gas
KW - Toxicology -- Animal models
KW - Lungs -- Infections
KW - Bacillus (Bacteria)
KW - Interferons
KW - T cells
KW - Macrophages
KW - BCG
KW - diesel exhaust
KW - infection
KW - interferon
KW - lung
KW - macrophages
KW - nitric oxide
KW - NK cells
N1 - Accession Number: 20606143; Saxena, R. K. 1,2; Saxena, Q. B. 2,3; Weissman, D. N. 3; Simpson, J. P. 3; Bledsoe, T. A. 3; Lewis, D. M. 3; Email Address: dlewis@cdc.gov; Affiliations: 1: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India; 2: Indian Council of Medical Research, New Delhi; 3: Analytical Services Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Center for Disease Control and Prevention, Morgantown, West Virginia 26505; Issue Info: May2003, Vol. 73 Issue 1, p66; Thesaurus Term: Genetic toxicology; Thesaurus Term: Diesel motor exhaust gas; Subject Term: Toxicology -- Animal models; Subject Term: Lungs -- Infections; Subject Term: Bacillus (Bacteria); Subject Term: Interferons; Subject Term: T cells; Subject Term: Macrophages; Author-Supplied Keyword: BCG; Author-Supplied Keyword: diesel exhaust; Author-Supplied Keyword: infection; Author-Supplied Keyword: interferon; Author-Supplied Keyword: lung; Author-Supplied Keyword: macrophages; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: NK cells; Number of Pages: 6p; Document Type: Article
L3 - 10.1093/toxsci/kfg048
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20606143&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Herman, Bruce A.
AU - Myers, Matthew R.
T1 - An analytic derivation for the transient temperature rise during an ultrasound pulse focused on bone
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
Y1 - 2003/05//
VL - 29
IS - 5
M3 - Article
SP - 771
SN - 03015629
AB - An analytic derivation is given for the maximum transient temperature rise due to millisecond ultrasound (US) pulses focused on bone. The temperature rise is found to have, within a small correction factor, a square-root dependence on the pulse duration and is independent of the focal diameter. The equation developed is essentially the same as that found in a previous paper that obtained the formula by numerical methods and subsequent curve fitting. (E-mail: bah@cdrh.fda.gov) [Copyright &y& Elsevier]
AB - Copyright of Ultrasound in Medicine & Biology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEATING
KW - TEMPERATURE
KW - Bone-at-focus
KW - Temperature rise
KW - Ultrasound
KW - Ultrasound heating
N1 - Accession Number: 9713463; Herman, Bruce A. 1; Email Address: bah@cdrh.fda.gov Myers, Matthew R. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA; Source Info: May2003, Vol. 29 Issue 5, p771; Subject Term: HEATING; Subject Term: TEMPERATURE; Author-Supplied Keyword: Bone-at-focus; Author-Supplied Keyword: Temperature rise; Author-Supplied Keyword: Ultrasound; Author-Supplied Keyword: Ultrasound heating; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/S0301-5629(02)00772-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9713463&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wood, J.M.
AU - Levandowski, R.A.
T1 - The influenza vaccine licensing process
JO - Vaccine
JF - Vaccine
Y1 - 2003/05//
VL - 21
IS - 16
M3 - Article
SP - 1786
SN - 0264410X
AB - Influenza vaccines are unique because they require a licensing process which includes a procedure for rapid annual updates to vaccine strains. The licensing procedures in the European Union and the USA are described as examples. In the event of an influenza pandemic, vaccines will be required urgently and licensing process should reflect such needs. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - VACCINES
KW - Influenza
KW - Licensing
KW - Pandemic
KW - Vaccines
N1 - Accession Number: 9445050; Wood, J.M. 1; Email Address: jwood@nibsc.ac.uk Levandowski, R.A. 2; Email Address: levandowski@cber.fda.gov; Affiliation: 1: National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, Hertfordshire, UK 2: Center for Biologics Evaluation and Research, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: May2003, Vol. 21 Issue 16, p1786; Subject Term: INFLUENZA; Subject Term: VACCINES; Author-Supplied Keyword: Influenza; Author-Supplied Keyword: Licensing; Author-Supplied Keyword: Pandemic; Author-Supplied Keyword: Vaccines; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/S0264-410X(03)00073-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9445050&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Santos, Norma
AU - Volotão, Eduardo M.
AU - Soares, Caroline C.
AU - Albuquerque, Maria Carolina M.
AU - da Silva, Fabiano M.
AU - Chizhikov, Vladimir
AU - Hoshino, Yasutaka
T1 - Erratum to “VP7 gene polymorphism of serotype G9 rotavirus strains and its impact on G genotype determination by PCR” [Virus Res. 90 (2002) 1–14]
JO - Virus Research
JF - Virus Research
Y1 - 2003/05//
VL - 93
IS - 1
M3 - Editorial
SP - 125
SN - 01681702
N1 - Accession Number: 9603196; Santos, Norma 1; Email Address: nsantos@micro.ufrj.br Volotão, Eduardo M. 1 Soares, Caroline C. 1 Albuquerque, Maria Carolina M. 1 da Silva, Fabiano M. 1 Chizhikov, Vladimir 2 Hoshino, Yasutaka 3; Affiliation: 1: Departamento de Virologia, Institute de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS-Bl. I, Ilha do Fundão, 21.941-590 Rio de Janeiro, RJ, Brazil 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD 20895, USA 3: Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: May2003, Vol. 93 Issue 1, p125; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/S0168-1702(02)00319-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9603196&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Santos, Norma
AU - Volotão, Eduardo M.
AU - Soares, Caroline C.
AU - Albuquerque, Maria Carolina M.
AU - da Silva, Fabiano M.
AU - Chizhikov, Vladimir
AU - Hoshino, Yasutaka
T1 - VP7 gene polymorphism of serotype G9 rotavirus strains and its impact on G genotype determination by PCR
JO - Virus Research
JF - Virus Research
Y1 - 2003/05//
VL - 93
IS - 1
M3 - Correction notice
SP - 127
SN - 01681702
AB - Rotaviruses are the single most important etiologic agents of severe diarrhea of infants and young children worldwide. Surveillance of rotavirus serotypes/genotypes (both VP7[G] and VP4[P]) is in progress globally in which polymerase chain reaction (PCR) has been the assay of choice. We investigated polymorphism of the VP7 gene of serotype G9 rotavirus strains and its impact on the determination of VP7 gene genotype by PCR assay. By VP7 gene sequence analysis, we and others have previously shown that the G9 rotavirus strains belong to one of three VP7 gene lineages. By PCR assay using three different sets of commonly used primers specific for G1-4, 8 and 9, 23 Brazilian G9 strains and 5 well-characterized prototype G9 strains which collectively represented all three VP7 gene lineages were typed as: (i) G3; (ii) G4; (iii) G9; (iv) G3 and G9; or (v) G9 and G4 depending on a primer pool employed. This phenomenon appeared to be due to: (i) a VP7 gene lineage-specific polymorphism, more specifically mutation(s) in the primer binding region of the VP7 gene of G9 strain; and (ii) the magnitude of difference in nucleotide homology at respective primer binding site between homotypic (G9) and heterotypic (G3 or G4) primers present in a primer pool employed. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - POLYMERASE chain reaction
KW - Gastroenteritis
KW - PCR G genotyping
KW - Rotavirus
KW - VP7 gene polymorphism
N1 - Accession Number: 9603197; Santos, Norma 1; Email Address: nsantos@micro.ufrj.br Volotão, Eduardo M. 1 Soares, Caroline C. 1 Albuquerque, Maria Carolina M. 1 da Silva, Fabiano M. 1 Chizhikov, Vladimir 2 Hoshino, Yasutaka 3; Affiliation: 1: Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, CCS-Bl. I, Ilha do Fundão, Rio de Janeiro, RJ 21.941-590, Brazil 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD 20895, USA 3: Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: May2003, Vol. 93 Issue 1, p127; Subject Term: ROTAVIRUSES; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Gastroenteritis; Author-Supplied Keyword: PCR G genotyping; Author-Supplied Keyword: Rotavirus; Author-Supplied Keyword: VP7 gene polymorphism; Number of Pages: 12p; Document Type: Correction notice
L3 - 10.1016/S0168-1702(02)00318-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9603197&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2003-00894-001
AN - 2003-00894-001
AU - Dionne, Raymond A.
AU - Witter, James
T1 - NIH-FDA Analgesic Drug Development Workshop: Translating scientific advances into improved pain relief.
JF - The Clinical Journal of Pain
JO - The Clinical Journal of Pain
JA - Clin J Pain
Y1 - 2003/05//May-Jun, 2003
VL - 19
IS - 3
SP - 139
EP - 147
CY - US
PB - Lippincott Williams & Wilkins
SN - 0749-8047
SN - 1536-5409
AD - Dionne, Raymond A., Pain & Neurosensory Mechanisms Branch, NIH/NIDCR, 10 Ctr. Dr., Room 1N-117, NIH, Bethesda, MD, US, 20892
N1 - Accession Number: 2003-00894-001. PMID: 12792552 Partial author list: First Author & Affiliation: Dionne, Raymond A.; National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, US. Release Date: 20031103. Correction Date: 20090831. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Analgesic Drugs; Chronic Pain; Drug Therapy; Pain Management; Pharmacology. Minor Descriptor: Pharmaceutical Industry. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: May-Jun, 2003.
AB - Analgesic drug development as currently undertaken is limited by a number of factors that contribute to the paucity of new analgesics introduced into clinical practice despite marked advances in delineating of the molecular-genetic mechanisms contributing to acute and chronic pain. The participants in this workshop explored the unmet need in analgesia and recommended strategies for enhancing analgesic drug development in the future. The workshop concluded that translating scientific advances into improved pain relief will require new thinking and a cooperative effort among the pharmaceutical industry, regulatory agencies, funding agencies, the biomedical research community, professional societies and clinicians. The workshop also recommended that a better understanding of the epidemiology of pain could contribute to improvement in clinical trial methodology and outcome measures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - analgesic drug development
KW - pain relief
KW - analgesics
KW - pharmaceutical industry
KW - biomedical research
KW - clinical practice
KW - acute pain
KW - chronic pain
KW - 2003
KW - Analgesic Drugs
KW - Chronic Pain
KW - Drug Therapy
KW - Pain Management
KW - Pharmacology
KW - Pharmaceutical Industry
KW - 2003
DO - 10.1097/00002508-200305000-00001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-00894-001&site=ehost-live&scope=site
UR - Raymond.Dionne@nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-00663-006
AN - 2003-00663-006
AU - Walrath, Christine
AU - Ybarra, Michele
AU - Holden, E. Wayne
AU - Liao, Qinghong
AU - Santiago, Rolando
AU - Leaf, Philip
T1 - Children with reported histories of sexual abuse: Utilizing multiple perspectives to understand clinical and psychosocial profiles.
JF - Child Abuse & Neglect
JO - Child Abuse & Neglect
JA - Child Abuse Negl
Y1 - 2003/05//
VL - 27
IS - 5
SP - 509
EP - 524
CY - Netherlands
PB - Elsevier Science
SN - 0145-2134
AD - Walrath, Christine, ORC Macro, 116 John Street, Suite 800, New York, NY, US, 10038
N1 - Accession Number: 2003-00663-006. PMID: 12718960 Partial author list: First Author & Affiliation: Walrath, Christine; ORC Macro, New York, NY, US. Release Date: 20031229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Abuse Reporting; Child Abuse; Early Experience; Sexual Abuse. Minor Descriptor: Psychosocial Factors. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: May, 2003.
AB - The current study examines multiple empirically based perspectives of behavior and functioning as they contribute to the clinical and psychosocial profile of children (aged 5 to 17.5 years) with reported histories of sexual abuse. 759 children with a reported history of sexual abuse were compared to 2,722 without such a history on caregiver and child reported behavior, clinician rated functioning, diagnosis, demographic variables, and life challenges. The multiple perspectives contributed unique and specific information to regression models caregiver-reported behavior contributed information about externalizing behavior while child-reported behavior added information about internalizing behavior and clinician ratings about self-harmful behavior. Child sexual abuse was associated with higher rates of depression and anxiety diagnoses, and lower rates of substance abuse, conduct, and attention deficit disorder diagnoses. The findings indicate that the profile of children entering into Comprehensive Community Mental Health Services with reported histories of sexual abuse, as compared to those without such histories, is complex and best understood via multiple perspectives. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sexual abuse
KW - psychosocial profiles
KW - life challenges
KW - reported history
KW - clinical profiles
KW - 2003
KW - Abuse Reporting
KW - Child Abuse
KW - Early Experience
KW - Sexual Abuse
KW - Psychosocial Factors
KW - 2003
DO - 10.1016/S0145-2134(03)00035-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-00663-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-03913-013
AN - 2003-03913-013
AU - Teich, Judith L.
AU - Buck, Jeffrey A.
T1 - Mental health services in employee assistance programs, 2001.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2003/05//
VL - 54
IS - 5
SP - 611
EP - 611
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Teich, Judith L., Substance Abuse & Mental Health Services Administration, Ctr for Mental Health Services, Office of Organization & Financing, 5600 Fishers Lane, Room 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2003-03913-013. PMID: 12719490 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Teich, Judith L.; Substance Abuse & Mental Health Services Administration, Ctr for Mental Health Services, Office of Organization & Financing, Rockville, MD, US. Release Date: 20031222. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Mental Health Services. Classification: Personnel Management & Selection & Training (3620); Health & Mental Health Services (3370). Location: US. Methodology: Empirical Study. Page Count: 1. Issue Publication Date: May, 2003.
AB - Presents recent information on the use of employee assistance programs (EAPs) and on the mental health services these programs provide. Data are from the 2001 Mercer/Foster Higgins National Survey of Employee-Sponsored Health Plans, which was based on a stratified random sample of employers with at least 10 employees. The survey collected information on health benefits provided by employers and included several questions on EAPs. 2100 responses were received to the EAP-related questions. 17% of firms offered EAPs in 2001. Nearly all employers reported that their EAPs provided counseling or referral services for work or family issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - employee assistance programs
KW - 2003
KW - Employee Assistance Programs
KW - Mental Health Services
KW - 2003
DO - 10.1176/appi.ps.54.5.611
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-03913-013&site=ehost-live&scope=site
UR - jteich@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-00257-013
AN - 2003-00257-013
AU - Chow, Julian Chun-Chung
AU - Jaffee, Kim
AU - Snowden, Lonnie
T1 - Racial/Ethnic Disparities in the Use of Mental Health Services in Poverty Areas.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/05//
VL - 93
IS - 5
SP - 792
EP - 797
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Chow, Julian Chun-Chung, School of Social Welfare, University of California at Berkeley, 209 Haviland Hall, No. 7400, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2003-00257-013. PMID: 12721146 Partial author list: First Author & Affiliation: Chow, Julian Chun-Chung; School of Social Welfare, University of California at Berkeley, Berkeley, CA, US. Release Date: 20031201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Health Care Utilization; Poverty Areas; Race and Ethnic Discrimination; Quality of Services. Minor Descriptor: Lower Income Level; Poverty; Racial and Ethnic Groups. Classification: Health & Mental Health Services (3370); Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: May, 2003.
AB - Objectives. This study examined racial/ethnic disparities in mental health service access and use at different poverty levels. Methods. We compared demographic and clinical characteristics and service use patterns of Whites, Blacks, Hispanics, and Asians living in low-poverty and high-poverty areas. Logistic regression models were used to assess service use patterns of minority racial/ethnic groups compared with Whites in different poverty areas. Results. Residence in a poverty neighborhood moderates the relationship between race/ethnicity and mental health service access and use. Disparities in using emergency and inpatient services and having coercive referrals were more evident in low-poverty than in high-poverty areas. Conclusions. Neighborhood poverty is a key to understanding racial/ethnic disparities in the use of mental health services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health service access
KW - racial disparity
KW - ethnic disparity
KW - poverty areas
KW - Whites
KW - minority population
KW - poverty level
KW - Blacks
KW - Hispanics
KW - Asians
KW - 2003
KW - Community Mental Health Services
KW - Health Care Utilization
KW - Poverty Areas
KW - Race and Ethnic Discrimination
KW - Quality of Services
KW - Lower Income Level
KW - Poverty
KW - Racial and Ethnic Groups
KW - 2003
DO - 10.2105/AJPH.93.5.792
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-00257-013&site=ehost-live&scope=site
UR - jchow99@uclink.berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-00393-005
AN - 2003-00393-005
AU - Mancini, Dominic J.
AU - Stecklov, Guy
AU - Stewart, John F.
T1 - The effect of structural characteristics on family planning program performance in Côte d'lvoire and Nigeria.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2003/05//
VL - 56
IS - 10
SP - 2123
EP - 2137
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Mancini, Dominic J., FDA/Center for Food Safety and Applied Nutrition, HFS-726, Room 2D-035, 5100 Paint Branch Parkway, College Park, MD, US, 20740
N1 - Accession Number: 2003-00393-005. PMID: 12697202 Partial author list: First Author & Affiliation: Mancini, Dominic J.; FDA/Center for Food Safety and Applied Nutrition, College Park, MD, US. Release Date: 20031229. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Demographic Characteristics; Family Planning; Health Care Services; Program Evaluation. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Ivory Coast; Nigeria. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: May, 2003.
AB - This paper uses Côte d'lvoire and Nigeria survey data on both supply and demand characteristics to examine how structural and demographic factors influence family planning provision and cost. The model, which takes into account the endogenous influence of service provision on average cost, explains provision well but poorly explains what influences service cost. We show that both size and specialization matter. In both countries, vertical (exclusive family planning) facilities provide significantly more contraception than integrated medical establishments. In the Nigeria sample, larger facilities also offer services at lower average cost. Since vertical facilities tend to be large, they at most incur no higher unit costs than integrated facilities. These results are consistent across most model specifications, and are robust to corrections for endogenous facility placement in Nigeria. Model results and cost recovery information point to the relative efficiency of the International Planned Parenthood Federation, which operates large, mostly vertically organized facilities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - structural factors
KW - demographic factors
KW - family planning provision
KW - family planning cost
KW - family planning programs
KW - Nigeria
KW - 2003
KW - Costs and Cost Analysis
KW - Demographic Characteristics
KW - Family Planning
KW - Health Care Services
KW - Program Evaluation
KW - 2003
DO - 10.1016/S0277-9536(02)00206-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-00393-005&site=ehost-live&scope=site
UR - dominic.mancini@cfsan.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Harrington-Brock, Karen
AU - Collard, Deborah D.
AU - Chen, Tao
T1 - Bromate induces loss of heterozygosity in the Thymidine kinase gene of L5178Y/Tk+/−-3.7.2C mouse lymphoma cells
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2003/05/09/
VL - 537
IS - 1
M3 - Article
SP - 21
SN - 13835718
AB - Potassium bromate (KBrO3) induces DNA damage and tumors in mice and rats, but is a relatively weak mutagen in microbial assays and the in vitro mammalian Hprt assay. Concern that there may be a human health risk associated with bromate, a disinfectant by-product of ozonation, has accompanied the increasing use of ozonation as an alternative to chlorination for treatment of drinking water. In this study, we have evaluated the mutagenicity of KBrO3 and sodium bromate (NaBrO3) in the Tk gene of mouse lymphoma cells. In contrast to the weak mutagenic activity seen in the previous studies, bromate induced a mutant frequency of over 100×10−6 at 0.6 mM with minimal cytotoxicity (70–80% survival) and over 1300×10−6 at 3 mM (∼10% survival). The increase in the Tk mutant frequency was primarily due to the induction of small colony of Tk mutants. Loss of heterozygosity (LOH) analysis of 384 mutants from control and 2.7 mM KBrO3-treated cells showed that almost all (99%) bromate-induced mutants resulted from LOH, whereas in the control cultures 77% of the Tk mutants were LOH. Our results suggest that bromate is a potent mutagen in the Tk gene of mouse lymphoma cells, and the mechanism of action primarily involves LOH. The ability of the mouse lymphoma assay to detect a wider array of mutational events than the microbial or V79 Hprt assays may account for the potent mutagenic response. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbiological assay
KW - Bromate
KW - Loss of heterozygosity
KW - Mouse lymphoma assay
KW - Mutation
N1 - Accession Number: 9713557; Harrington-Brock, Karen 1; Collard, Deborah D. 1; Chen, Tao 2; Email Address: tchen@nctr.fda.gov; Affiliations: 1: National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27709, USA; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Issue Info: May2003, Vol. 537 Issue 1, p21; Thesaurus Term: Microbiological assay; Subject Term: Bromate; Author-Supplied Keyword: Loss of heterozygosity; Author-Supplied Keyword: Mouse lymphoma assay; Author-Supplied Keyword: Mutation; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S1383-5718(03)00044-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9713557&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murashov, Vladimir
T1 - Ab initio cluster calculations of silica surface sites
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
Y1 - 2003/05/13/
VL - 650
IS - 1-3
M3 - Article
SP - 141
SN - 00222860
AB - Silica surface sites, which can be formed in cleavage processes, and their hydrolyzed counterparts are investigated with ab initio cluster calculations. Natural Bond Orbital (NBO) theory is used to characterize bonding around silica surface sites. Higher energy lone pairs of electrons on oxygen atoms either hyperconjugate to vicinal silanol/siloxane antibonding orbitals or backdonate electron density via donor–acceptor π-type bonding with participation of pd or p hybrids on silicon atoms. Upon substitution of hydroxyl groups of orthosilicic acid with silica monomers the strength of siloxane and silanol Si–O bonding increases as energies of bonding orbitals and contributions from p-orbitals decrease. Silanone sites and a complementary pair of silyl/siloxy radical sites are found to be the most stable geminal and single non-hydrolyzed sites, respectively. Atomic charges based on natural wavefunctions and on fitting to electrostatic potential, and characteristic bands of IR spectra associated with siloxane and silanol stretching vibrations of silica surface sites are reported. [Copyright &y& Elsevier]
AB - Copyright of Journal of Molecular Structure is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - INFRARED spectra
KW - Charges
KW - Geminal silanols
KW - Infra-Red spectra
KW - Natural Bond Orbitals
KW - Silica
N1 - Accession Number: 9655989; Murashov, Vladimir 1; Email Address: vmurashov@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA; Source Info: May2003, Vol. 650 Issue 1-3, p141; Subject Term: SILICA; Subject Term: INFRARED spectra; Author-Supplied Keyword: Charges; Author-Supplied Keyword: Geminal silanols; Author-Supplied Keyword: Infra-Red spectra; Author-Supplied Keyword: Natural Bond Orbitals; Author-Supplied Keyword: Silica; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/S0022-2860(03)00098-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9655989&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Chevarley, Frances
T1 - Reformatting a self-administered questinnaire based on item non-response.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2003/05/14/2003 Annual Meeting, Nashville, TN
M3 - Conference Paper
SP - N.PAG
AB - This poster summarizes item non-response for two years of a self-administered questionnaire used in the Medical Expenditure Panel Survey (MEPS). Starting in 2000, a Self-Administered Questionnaire (SAQ) and a number of other enhancements were added to the MEPS. The SAQ is part of the Household Component of the MEPS. After an initial review of item non-response in the 2000 SAQ using a preliminary coded file and while planning for the 2001 SAQ, it was noticed that certain questions had higher item non-response than other questions in the SAQ. For example, the questions on the last page had higher non-response than questions on the previous page and the very last question had even higher nonresponse–12.8 percent- based on a preliminary 2000 MEPS SAQ coded file–possibly indicating additional formatting issues for the last question. Based on item non-response analysis of the preliminary coded file for the 2000 MEPS SAQ, several design changes were incorporated into the 2001 MEPS SAQ. For example, we improved upon our survey instructions by adding specific skip instructions, and adding instructions on each page to go to the next page. In addition, the last question was reformatted and moved from the last page to the page before it. In this presentation, comparisons will be made between item non-response for the 2000 and 2001 questionnaires. Issues regarding whether the methodology involved in determining general principles of self-administered questionnaire design can positively influence non-response patterns in a ‘before/after’ sense, will also be discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUESTIONNAIRES
KW - MEDICAL care costs
KW - SURVEYS
KW - RESPONSE rates
KW - administered
KW - item
KW - MEPS
KW - non
KW - proxy
KW - questionnaire
KW - reporting
KW - response
KW - self
N1 - Accession Number: 16022398; Chevarley, Frances 1; Email Address: fchevarl@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: 2003 Annual Meeting, Nashville, TN, pN.PAG; Subject Term: QUESTIONNAIRES; Subject Term: MEDICAL care costs; Subject Term: SURVEYS; Subject Term: RESPONSE rates; Author-Supplied Keyword: administered; Author-Supplied Keyword: item; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: non; Author-Supplied Keyword: proxy; Author-Supplied Keyword: questionnaire; Author-Supplied Keyword: reporting; Author-Supplied Keyword: response; Author-Supplied Keyword: self; Number of Pages: 0p; Document Type: Conference Paper
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16022398&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Chevarley, Frances
T1 - Comparison of Self- versus Proxy-Reporting of General Health Status using the 2000 Medical Expenditure Panel Survey (MEPS).
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2003/05/14/2003 Annual Meeting, Nashville, TN
M3 - Conference Paper
SP - N.PAG
AB - This paper summarizes an analyses of self-reporting versus proxy-reporting of general health status using the 2000 Medical Expenditure Panel Survey (MEPS). Starting in 2000, a Self-Administered Questionnaire (SAQ) and a number of other enhancements were added to the Medical Panel Expenditure Survey (MEPS), a nationally representative survey of the civilian non-institutionalized U.S. population. Included in the 2000 SAQ is a general health question that is part of the SF-12 battery of questions. This question is almost identical to the general health status question already contained in the MEPS core. Although the response categories are the same, the wording of the two health status questions differ slightly. Having adults self-report questions in the SAQ contrasts with the process of having a knowledgeable adult report for themselves and other family members for the core MEPS questions. These data provide the basis of analysis. A comparison will be made of the responses to the core health status question (for both self and proxy respondents) compared with self-reported health status from the SAQ. Although there is much literature on the correlation of self report with other health related variables and of it’s predictive value of survival, this analysis should add to the knowledge of self versus proxy reporting of general health. This should also add to the knowledge of self reporting of general health at different times. The findings in this analysis are subject to the following limitations: the mode of interview is different for the two questions–interviewer administered CAPI versus a self-administered paper questionnaire; the wording of the two questions differ slightly; the two questions may be answered at different times; and there was no outside validation measures so differences only could be assessed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH status indicators
KW - MEDICAL care costs
KW - SURVEYS
KW - QUESTIONNAIRES
KW - Administered
KW - MEPS
KW - nonresponse
KW - of
KW - PAQ
KW - Parent
KW - patterns
KW - Proxy
KW - Questionnaire
KW - Reporting
KW - Self
N1 - Accession Number: 16022399; Chevarley, Frances 1; Email Address: fchevarl@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: 2003 Annual Meeting, Nashville, TN, pN.PAG; Subject Term: HEALTH status indicators; Subject Term: MEDICAL care costs; Subject Term: SURVEYS; Subject Term: QUESTIONNAIRES; Author-Supplied Keyword: Administered; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: nonresponse; Author-Supplied Keyword: of; Author-Supplied Keyword: PAQ; Author-Supplied Keyword: Parent; Author-Supplied Keyword: patterns; Author-Supplied Keyword: Proxy; Author-Supplied Keyword: Questionnaire; Author-Supplied Keyword: Reporting; Author-Supplied Keyword: Self; Number of Pages: 0p; Document Type: Conference Paper
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16022399&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Kennet, Joel
AU - Gfroerer, Joe
T1 - Effects of a $30 Incentive on Response Rates and Costs in the 2002 National Survey on Drug Use and Health.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2003/05/14/2003 Annual Meeting, Nashville, TN
M3 - Conference Paper
SP - N.PAG
AB - The National Survey on Drug Use and Health is an ongoing face-to-face household survey of approximately 150,000 households and 67,500 persons each year. The survey, which was called the National Household Survey on Drug Abuse prior to 2002, covers the U.S. civilian noninstitutionalized population aged 12 and older. In 2002 the survey began offering respondents a $30 cash incentive. The offer of an incentive was initiated within the context of other methodological developments in the survey. These other methodological changes included the name change and an increase in interviewers’ adherence to study protocols brought about by enhanced emphasis during initial training and retraining. These changes resulted in a significant increase in response rate. Moreover, the increased response rate was achieved in conjunction with a net decrease in costs incurred per completed interview. This paper presents an analysis of response rate patterns by geographic and demographic characteristics, as well as interviewer characteristics. Changes in the sample composition and possible effects on estimates of drug use prevalence are discussed. Potential implications for other large-scale surveys are also discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG abuse
KW - HEALTH surveys
KW - HOUSEHOLD surveys
KW - RESPONDENTS
KW - MONETARY incentives
KW - incentives
KW - methodology
KW - nonresponse
KW - rates
KW - response
KW - survey
N1 - Accession Number: 16022410; Kennet, Joel 1; Email Address: jkennet@samhsa.gov Gfroerer, Joe 1; Email Address: jgfroere@samhsa.gov; Affiliation: 1: Substance Abuse and Mental Health Services Administration; Source Info: 2003 Annual Meeting, Nashville, TN, pN.PAG; Subject Term: DRUG abuse; Subject Term: HEALTH surveys; Subject Term: HOUSEHOLD surveys; Subject Term: RESPONDENTS; Subject Term: MONETARY incentives; Author-Supplied Keyword: incentives; Author-Supplied Keyword: methodology; Author-Supplied Keyword: nonresponse; Author-Supplied Keyword: rates; Author-Supplied Keyword: response; Author-Supplied Keyword: survey; Number of Pages: 0p; Document Type: Conference Paper
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16022410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Wilson, Barbara
AU - Kamimoto, Laurie
AU - Whitaker, Karen
AU - Williams, Melonie
AU - Dockins, Chris
AU - Kim, Henry
AU - Posnick, Lauren
AU - Canfield, Beth
T1 - Go With the Flow: Cognitive Testing of a Multi-mode, Multi-Agency Survey about Drinking Water.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2003/05/14/2003 Annual Meeting, Nashville, TN
M3 - Conference Paper
SP - N.PAG
AB - The Centers for Disease Control and Prevention (CDC), jointly with the Food and Drug Administration and the Environmental Protection Agency, plan to conduct an anonymous Internet-based survey to assess the use of bottled water, tap water and home water filtration systems. The survey will include questions about water perceptions, knowledge, reasons for bottled water or water filtration system use, and attendant costs. A phone version of the survey will also be developed to assess the same information. The survey questions were assessed in the CDC Questionnaire Design Research Laboratory using two study modes: a pilot Internet survey site and telephone-administered survey. After revision, the final Internet-based survey will be launched in 2003. In order to produce a brief and coherent survey instrument, the investigators had to combine the goals, language and theoretical constructs of the different supporting agencies dealing with hidden springs of unrecognized differences in bureaucratic settings. For example, the FDA asked questions about knowledge of regulations - questions that carried implicit assumptions of the public’s awareness of and trust in government’s role in water issues. Other questions in the draft instrument were intended to provide data for ‘Averting Behavior’ analysis, a techniques used by EPA economists to measure ‘Willingness to Pay’. The questions ask respondents how much they pay for bottled or filtered water, and how much safer they think bottled or filtered water is than tap water. Bridging such assorted cognitive domains was challenging. This presentation will describe the findings of this multi-mode, multi-agency project. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURVEYS
KW - RESIDENTIAL water consumption
KW - BOTTLED water
KW - DRINKING water
KW - WATER -- Filtration
KW - based
KW - cognitive
KW - Internet
KW - interviewing
KW - safety
KW - survey
KW - water
N1 - Accession Number: 16022337; Wilson, Barbara 1; Email Address: BWilson@cdc.gov Kamimoto, Laurie 2; Email Address: LEK0@cdc.gov Whitaker, Karen 2; Email Address: KRS0@cdc.gov Williams, Melonie 3; Email Address: williams.melonie@epamail.epa.gov Dockins, Chris 4; Email Address: Dockins.Chris@EPAmail.gov Kim, Henry 5; Email Address: HKim@cfsan.fda.gov Posnick, Lauren 5; Email Address: LPosnick@cfsan.fda.gov Canfield, Beth 1; Email Address: BOC7@cdc.gov; Affiliation: 1: National Center for Health Statistics 2: Centers for Disease Control and Prevention 3: Environnmental Protection Agency 4: Environmental Protection Agency 5: Food and Drug Administration; Source Info: 2003 Annual Meeting, Nashville, TN, pN.PAG; Subject Term: SURVEYS; Subject Term: RESIDENTIAL water consumption; Subject Term: BOTTLED water; Subject Term: DRINKING water; Subject Term: WATER -- Filtration; Author-Supplied Keyword: based; Author-Supplied Keyword: cognitive; Author-Supplied Keyword: Internet; Author-Supplied Keyword: interviewing; Author-Supplied Keyword: safety; Author-Supplied Keyword: survey; Author-Supplied Keyword: water; NAICS/Industry Codes: 312112 Bottled Water Manufacturing; NAICS/Industry Codes: 413210 Non-alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 312110 Soft drink and ice manufacturing; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 0p; Document Type: Conference Paper
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16022337&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Zhuo
AU - Leonard, Stephen S.
AU - Huang, Chuanshu
AU - Vallyathan, Val
AU - Castranova, Vince
AU - Shi, Xianglin
T1 - Role of reactive oxygen species and MAPKs in vanadate-induced G2/M phase arrest
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2003/05/15/
VL - 34
IS - 10
M3 - Article
SP - 1333
SN - 08915849
AB - Cell growth arrest is an important mechanism in maintaining genomic stability and integrity in response to environmental stress. Using the human lung alveolar epithelial cancer cell line A549, we investigated the role of reactive oxygen species (ROS), extracellular signal-regulated protein kinase (ERK), and p38 protein kinase in vanadate-induced cell growth arrest. Exposure of cells to vanadate led to cell growth arrest at the G2/M phase and caused upregulation of p21 and phospho-cdc2 and degradation of cdc25C in a time- and dose-dependent manner. Vanadate stimulated mitogen-activated protein kinases (MAPKs) family members, as determined by the phosphorylation of ERK and p38. PD98059, an inhibitor of ERK, and SB202190, an inhibitor of p38, inhibited vanadate-induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C. In addition to hydroxyl radical (•OH) formation, cellular reduction of vanadate generated superoxide radical (O2•−) and hydrogen peroxide (H2O2), as determined by confocal microscopy using specific dyes. Generation of O2•− and H2O2 was inhibited by specific antioxidant enzymes, superoxide dismutase (SOD) and catalase, respectively. ROS activate ERK and p38, which in turn upregulate p21 and cdc2 and cause degradation of cdc25C, leading to cell growth arrest at the G2/M phase. Specific ROS affect different MAPK family members and cell growth regulatory proteins with different potencies. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL cycle
KW - ACTIVE oxygen
KW - Cell cycle regulatory proteins
KW - Growth arrest
KW - MAPKs
KW - Reactive oxygen species
KW - Vanadate
N1 - Accession Number: 9603862; Zhang, Zhuo 1,2 Leonard, Stephen S. 1,2 Huang, Chuanshu 3 Vallyathan, Val 1 Castranova, Vince 1 Shi, Xianglin 1,2; Email Address: xshi@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA 2: Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA 3: Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, NY, USA; Source Info: May2003, Vol. 34 Issue 10, p1333; Subject Term: CELL cycle; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: Cell cycle regulatory proteins; Author-Supplied Keyword: Growth arrest; Author-Supplied Keyword: MAPKs; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Vanadate; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0891-5849(03)00145-X
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khaidakov, Magomed
AU - Heflich, Robert H.
AU - Manjanatha, Mugimane G.
AU - Myers, Meagan B.
AU - Aidoo, Anane
T1 - Accumulation of point mutations in mitochondrial DNA of aging mice
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/05/15/
VL - 526
IS - 1/2
M3 - Article
SP - 1
SN - 00275107
AB - Mitochondrial DNA (mtDNA) exists in a highly genotoxic environment created by exposure to reactive oxygen species, somewhat deficient DNA repair, and the relatively low fidelity of polymerase gamma. Given the severity of the environment, it was anticipated that mutation accumulation in the mtDNA of aging animals should exceed that of nuclear genes by several orders of magnitude. We have analyzed fragments amplified from the D-loop region of mtDNA from 2 to 22-month-old mice. The amplified 432 bp fragments were cloned into plasmid vectors, and plasmid DNAs from individual clones were purified and sequenced. None of 110 fragments from young mice contained a mutation, while 9 of 87 clones originating from old animals contained base substitutions (chi square = 11.9, P<0.001 ). The estimated mutation frequency in mtDNA from old mice was 11.6±2.7 or 25.4±7.8 per 105 nucleotides (depending on assumptions of clonality), which exceeds existing estimates for mutation frequencies for nuclear genes by approximately 1000-fold. Our data suggest that at 22 months of age, which roughly corresponds to 3/4 of the mouse natural life span, most mtDNA molecules carry multiple point mutations. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIAL DNA
KW - GENETIC toxicology
KW - Aging
KW - D-loop region
KW - Mitochondrial DNA
KW - Mutation frequency
KW - PCR
N1 - Accession Number: 9546271; Khaidakov, Magomed 1,2,3 Heflich, Robert H. 1 Manjanatha, Mugimane G. 1 Myers, Meagan B. 1,2,4 Aidoo, Anane 1; Email Address: aaidoo@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, US FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3: Department of Geriatrics, Little Rock, AR 72205, USA 4: Department of Pharmacology & Toxicology, Little Rock, AR 72205, USA; Source Info: May2003, Vol. 526 Issue 1/2, p1; Subject Term: MITOCHONDRIAL DNA; Subject Term: GENETIC toxicology; Author-Supplied Keyword: Aging; Author-Supplied Keyword: D-loop region; Author-Supplied Keyword: Mitochondrial DNA; Author-Supplied Keyword: Mutation frequency; Author-Supplied Keyword: PCR; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0027-5107(03)00010-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Lucia H.
AU - Frasch, Carl E.
AU - Falk, Lydia A.
AU - Klein, David L.
AU - Deal, Carolyn D.
T1 - Correlates of immunity for pneumococcal conjugate vaccines
JO - Vaccine
JF - Vaccine
Y1 - 2003/05/16/
VL - 21
IS - 17/18
M3 - Article
SP - 2199
SN - 0264410X
AB - The purpose of the NIAID/FDA joint workshop, “correlates of immunity for pneumococcal conjugate vaccines (PCVs),” was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Animal and clinical data support functional antibody as the basis for protection, but IgG antibody concentration has conventionally been the principle immunologic parameter for non-inferiority comparisons. No consensus for a pre-defined threshold antibody level was reached. Affinity maturation may contribute to protection, but its role has not been established. Opsonophagocytic activity, avidity and immunologic memory are important secondary measures to characterise functional antibody and long-term protective responses. Immunologic memory may also be useful for evaluation of new vaccine serotypes. More definitive qualitative and quantitative immunogenicity criteria for use by National Control Authorities still need to be established. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNITY
KW - STREPTOCOCCUS pneumoniae
KW - Conjugate vaccine
KW - Correlate
KW - Pneumococcal
N1 - Accession Number: 9544490; Lee, Lucia H. 1; Email Address: leel@cber.fda.gov Frasch, Carl E. 2 Falk, Lydia A. 3 Klein, David L. 3 Deal, Carolyn D. 3; Affiliation: 1: Division of Vaccines and Related Products Applications, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-475, 1401 Rockville Pike, Rockville, MD 20852, USA 2: Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA 3: Division of Microbiology and Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Building 6700-B, 6700 Rockledge Drive, Bethesda, MD 20817, USA; Source Info: May2003, Vol. 21 Issue 17/18, p2199; Subject Term: IMMUNITY; Subject Term: STREPTOCOCCUS pneumoniae; Author-Supplied Keyword: Conjugate vaccine; Author-Supplied Keyword: Correlate; Author-Supplied Keyword: Pneumococcal; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0264-410X(03)00025-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106855849
T1 - Use of containment pans and lids for autoclaving caustic solutions.
AU - Brown SA
AU - Merritt K
Y1 - 2003/06//2003 Jun
N1 - Accession Number: 106855849. Language: English. Entry Date: 20030808. Revision Date: 20150819. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Sterilization and Disinfection -- Methods
KW - Sterilization and Disinfection -- Equipment and Supplies
KW - Caustics
KW - Creutzfeldt-Jakob Syndrome -- Transmission
KW - Equipment Design
KW - Volatilization
KW - Creutzfeldt-Jakob Syndrome -- Prevention and Control
KW - Lye -- Adverse Effects
KW - Equipment Contamination -- Prevention and Control
KW - Experimental Studies
KW - Product Evaluation
KW - Equipment Safety
KW - Hydrogen-Ion Concentration
KW - Human
SP - 257
EP - 260
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 31
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - As a means of decontaminating instruments possibly exposed to Creutzfeldt-Jakob disease, the World Health Organization has recommended immersion and autoclaving in sodium hydroxide. However, this recommendation has raised concerns of possible damage to autoclaves, and hazards to operators as a result of the caustic vapors. A series of experiments has been conducted that demonstrate that there are containment pan-and-lid combinations in which instruments can be autoclaved in sodium hydroxide without risk to the autoclave or the operator.
SN - 0196-6553
AD - Division of Mechanics and Materials Science, Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, 9200 Corporate Blvd, Rockville MD 20852
U2 - PMID: 12806365.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Chen, Junjian Z.
AU - Kadlubar, Fred F.
T1 - A new clue to glaucoma pathogenesis
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 2003/06//
VL - 114
IS - 8
M3 - Editorial
SP - 697
SN - 00029343
N1 - Accession Number: 9994576; Chen, Junjian Z.; Email Address: fkadlubar@nctr.fda.gov Kadlubar, Fred F. 1; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Jun2003, Vol. 114 Issue 8, p697; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/S0002-9343(03)00199-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Berg, AO;
AU - US Preventive Serv Task Force;
T1 - Postmenopausal hormone replacement therapy for the primary prevention of chronic conditions: Recommendations and rationale
CT - Postmenopausal hormone replacement therapy for the primary prevention of chronic conditions: Recommendations and rationale
JO - American Journal of Nursing (USA)
JF - American Journal of Nursing (USA)
Y1 - 2003/06/01/
VL - 103
IS - Jun
SP - 83
EP - 91
SN - 0002936X
AD - US Prevent Serv Task Force, Agcy Healthcare Res & Qual, 6010 Execut Blvd,Suite 300, Rockville, MD 20852, USA uspstf@ahrq.gov
N1 - Accession Number: 40-15219; Language: English; References: 32; Journal Coden: AJNUAK; Human Indicator: Yes; Section Heading: Pharmacology; Toxicity
N2 - The risks and benefits of postmenopausal hormone replacement therapy for the primary prevention of chronic conditions are discussed; recommendations of the U.S. Preventive Services Tash Force (USPSTF) are presented.
KW - Estrogens--postmenopause;
KW - United States Preventive Services Task Force--protocols;
KW - Protocols--estrogens;
KW - Toxicity--estrogens;
KW - Osteoporosis--estrogens;
KW - Fractures--estrogens;
KW - Postmenopause--estrogens;
KW - Breast neoplasms--estrogens;
KW - Coronary disease--estrogens;
KW - Thromboembolism--estrogens;
KW - Ovarian neoplasms--estrogens;
KW - Cholecystitis--estrogens;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Schroeder, Carl M.
AU - Parlor, Karen W.
AU - Marsh, Terence L.
AU - Ames, N. Kent
AU - Goeman, Amanda K.
AU - Walker, Robert D.
T1 - Characterization of the predominant anaerobic bacterium recovered from digital dermatitis lesions in three Michigan dairy cows
JO - Anaerobe
JF - Anaerobe
Y1 - 2003/06//
VL - 9
IS - 3
M3 - Article
SP - 151
SN - 10759964
AB - Digital dermatitis is a superficial epidermatitis of the feet of cattle. Data from previous work suggest that spirochaetes, Campylobacter spp., and Bacteroides spp. may be important in the disease, but the etiology of this disease is not entirely clear. Tissue samples collected from digital dermatitis lesions in three Holstein–Friesian cows from a Michigan dairy yielded a predominant colony type when incubated anaerobically on blood agar at 35°C for 24–48 h. The isolate was a non-flagellated Gram-negative rod, 7 μM long and <0.5 μM wide; its growth was strictly anaerobic and resulted in slight ß-hemolysis on blood agar; 16S rRNA gene sequence analysis indicated it belonged to the cytophoga–flexibacter–bacteroides phylum. The finding that this bacterium was the predominant anaerobe recovered from digital dermatitis lesions suggests it may be involved in the digital dermatitis disease process. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - SPIROCHETES
KW - BACTERIAL diseases
KW - RNA
KW - Bacteroides
KW - CFB phylum
KW - Cow
KW - Digital dermatitis
N1 - Accession Number: 10567792; Schroeder, Carl M. 1 Parlor, Karen W. 2 Marsh, Terence L. 3 Ames, N. Kent 2 Goeman, Amanda K. 2 Walker, Robert D. 4; Email Address: rwalker@cvm.fda.gov; Affiliation: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA 2: College of Veterinary Medicine, Michigan State University, East Lansing, MI 48909, USA 3: Department of Microbiology, Michigan State University, East Lansing, MI 48909, USA 4: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA; Source Info: Jun2003, Vol. 9 Issue 3, p151; Subject Term: SKIN -- Inflammation; Subject Term: SPIROCHETES; Subject Term: BACTERIAL diseases; Subject Term: RNA; Author-Supplied Keyword: Bacteroides; Author-Supplied Keyword: CFB phylum; Author-Supplied Keyword: Cow; Author-Supplied Keyword: Digital dermatitis; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S1075-9964(03)00084-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106877341
T1 - Motorcycle casualties sustained during Daytona Beach Bike Week 2000: lessons learned.
AU - Kanny D
AU - Schieber RA
AU - Jones BH
AU - Ryan GW
AU - Sorensen BJ
Y1 - 2003/06//2003 Jun
N1 - Accession Number: 106877341. Language: English. Entry Date: 20031024. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646.
KW - Accidents, Traffic
KW - Sporting Events
KW - Florida
KW - Epidemiological Research
KW - Descriptive Statistics
KW - Human
SP - 792
EP - 797
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
JA - ANN EMERG MED
VL - 41
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 0196-0644
AD - Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, US Public Health Service, Dept of Health and Human Services, Atlanta, GA
U2 - PMID: 12764332.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kulka, M.
AU - Chen, A.
AU - Ngo, D.
AU - Bhattacharya, S. S.
AU - Cebula, T. A.
AU - Goswami, B. B.
T1 - The cytopathic 18f strain of Hepatitis A virus induces RNA degradation in FrhK4 cells.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2003/06//
VL - 148
IS - 7
M3 - Article
SP - 1275
EP - 1300
SN - 03048608
AB - Summary. The mechanism responsible for the induction of apoptosis by the rapidly replicating HM175/18f strain of Hepatitis A virus (HAV) was investigated. Full length HAV RNA and viral capsid protein VP1 were detected in 18f infected cells at earlier times post-infection than in HM175/clone 1 infected cells. Analysis of total cellular RNA from HM175/18f infected FrhK4 cells by denaturing agarose gel electrophoresis and Northern blot hybridization revealed extensive degradation of both the 28S and 18S ribosomal RNA (rRNA) molecules. Similar degradation was observed when these cells were infected with Human coxsackievirus B1, a fast replicating enterovirus. In contrast, the parental strain of 18f, HM175/clone 1 did not induce RNA degradation. Inhibition of RNA degradation correlated with inhibition of virus replication. The pattern of rRNA degradation resembled degradation of rRNAs by RNase L, an enzyme activated in interferon-treated cells following infection with certain viruses. Ribosomal RNA degradation was accompanied by the reduction in the levels of several cellular RNAs including those for β-actin and glyceraldehyde-3-phosphate dehydrogenase, while the levels of c-myc and c-jun were higher. Interferon mRNAs could not be detected in either infected or mock-infected control cells, and STAT1, a key regulator of interferon action was not phosphorylated following virus infection. These results reveal a heretofore-undescribed pathway that involves the regulation of RNA degradation and apoptosis following HAV/18f replication in FrhK4 cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - ENTEROVIRUSES
KW - RNA
KW - CELLS
KW - HYBRIDIZATION
KW - GEL electrophoresis
N1 - Accession Number: 16936100; Kulka, M. 1 Chen, A. 1 Ngo, D. 1 Bhattacharya, S. S. 1 Cebula, T. A. 1 Goswami, B. B. 1; Affiliation: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Molecular Biology, Laurel, MD, U.S.A.; Source Info: Jun2003, Vol. 148 Issue 7, p1275; Subject Term: HEPATITIS A virus; Subject Term: ENTEROVIRUSES; Subject Term: RNA; Subject Term: CELLS; Subject Term: HYBRIDIZATION; Subject Term: GEL electrophoresis; Number of Pages: 26p; Document Type: Article
L3 - 10.1007/s00705-003-0110-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rainald A. Zeuner
AU - Daniela Verthelyi
AU - Mayda Gursel
AU - Ken J. Ishii
AU - Dennis M. Klinman
T1 - Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2003/06//
VL - 48
IS - 6
M3 - Article
SP - 1701
EP - 1707
SN - 00043591
AB - To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis. Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored. Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas systemic treatment with suppressive ODNs reduced this susceptibility. CD11c+ cells played a key role in mediating host sensitivity to arthritis. These cells were the dominant source of tumor necrosis factor α production in CpG-stimulated animals and transferred resistance to arthritis from mice treated with suppressive ODNs. Systemic exposure to immunostimulatory and immunosuppressive DNA influences host susceptibility to local inflammatory challenge. Current findings raise the possibility that suppressive ODNs may be useful in the prevention/treatment of proinflammatory diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTHRITIS
KW - MICE
KW - DISEASE susceptibility
KW - CELLS
KW - DNA
N1 - Accession Number: 11676364; Rainald A. Zeuner Daniela Verthelyi 1 Mayda Gursel 1 Ken J. Ishii 1 Dennis M. Klinman 1; Affiliation: 1: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland; Source Info: Jun2003, Vol. 48 Issue 6, p1701; Subject Term: ARTHRITIS; Subject Term: MICE; Subject Term: DISEASE susceptibility; Subject Term: CELLS; Subject Term: DNA; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Armstrong, George
AU - Governale, Laura
T1 - Rapid Increase in the Use of Oral Antidiabetic Drugs in the United States, 1990-2001.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2003/06//
VL - 26
IS - 6
M3 - Article
SP - 1852
EP - 1855
SN - 01495992
AB - OBJECTIVE — To describe the use of oral antidiabetic drugs for management of type 2 diabetes in the U.S. from 1990 through 2001. RESEARCH DESIGN AND METHODS — Data on oral antidiabetic drugs were derived from two pharmaceutical marketing databases from IMS Health, the National Prescription Audit Plus and the National Disease and Therapeutic Index. RESULTS — In 1990, 23.4 million outpatient prescriptions of oral antidiabetic agents were dispensed. By 2001, this number had increased 3.9-fold, to 91.8 million prescriptions. Glipizide and glyburide, two sulfonylurea medications, accounted for ∼77% of prescriptions of oral antidiabetic drugs in 1990 and 35.5% of prescriptions in 2001. By 2001, the biguanide metformin (approved in 1995) had captured ∼33% of prescriptions, and the thiazolidinedione insulin sensitizers (rosiglitazone and pioglitazone marketed beginning in 1999) accounted for ∼17% of market share. Compared with patients treated in 1990, those in 2001 were proportionately younger and they more often used oral antidiabetic drugs and insulin in combination. Internists and general and family practitioners were the primary prescribers of this class of drugs. CONCLUSIONS — Consistent with the reported increase in the prevalence of type 2 diabetes, the number of dispensed outpatient prescriptions of oral antidiabetic drugs increased rapidly between 1990 and 2001. This period was marked by an increase in the treatment of younger people and the use of oral antidiabetic drugs in combination. With the approval in the last decade of several new types of oral antidiabetic medications with different mechanisms of action, options for management of type 2 diabetes have expanded. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPOGLYCEMIC agents
KW - DIABETES -- Treatment
KW - UNITED States
N1 - Accession Number: 9995701; Wysowski, Diane K. 1; Email Address: wysowski@cder.fda.gov Armstrong, George 1 Governale, Laura 1; Affiliation: 1: Office of Drug Safety, Food and Drug Administration, Rockville, Maryland; Source Info: Jun2003, Vol. 26 Issue 6, p1852; Subject Term: HYPOGLYCEMIC agents; Subject Term: DIABETES -- Treatment; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 2885
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Park, Jae Hyun
AU - Kim, Hyung Soo
AU - Chung, Seung Tae
AU - Eom, Juno H.
AU - Nam, Ki Taek
AU - Oh, Hye Young
T1 - Evaluation of cell proliferation in ear and lymph node using BrdU immunohistochemistry for mouse ear swelling test
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2003/06//
VL - 14
IS - 1/2
M3 - Article
SP - 61
SN - 13826689
AB - The mouse ear swelling test (MEST) was developed as an alternative to guinea pig models for measuring the contact sensitization potential. However, the MEST relies on the quantitative measurement of ear swelling by micrometer as the means of determining the endpoint. The purpose of this study was to investigate the possibility of using cell proliferation in the ear and lymph node by bromodeoxyuridine (BrdU) immunohistochemistry as a reliable marker for MEST. Female Balb/c mice were treated by the topical application of various sensitizers, 2,4-dinitrochlorobenzene (DNCB), toluene diisocyanate (TDI) and α-hexylcinnamaldehyde (HCA) and an irritant, sodium lauryl sulfate (SLS) following the protocol of MEST. The proliferation of cells in the ear and auricular lymph node was analyzed by BrdU incorporations into cells. There were significant increases in the cell proliferations of the ear and auricular lymph node in mice treated with DNCB and TDI compared to the vehicle control. All allergens and the irritant were correctly identified by the MEST using BrdU immunohistochemistry of lymph node responses. The standard MEST assay showed positive results in the case of the strong sensitizers, DNCB and TDI. However, HCA and SLS were not correctly identified in the ear swelling assay. These results suggest that the measurement of cell proliferation in the auricular lymph node using BrdU immunohistochemistry could provide a reliable marker for MEST. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunohistochemistry
KW - Ear diseases
KW - BrdU (bromodeoxyuridine)
KW - Ear swelling
KW - Lymph node
KW - MEST
N1 - Accession Number: 9858473; Lee, Jong Kwon; Email Address: jkleest@kfda.go.kr; Park, Jae Hyun 1; Kim, Hyung Soo 1; Chung, Seung Tae 1; Eom, Juno H. 1; Nam, Ki Taek 1; Oh, Hye Young 1; Affiliations: 1: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Issue Info: Jun2003, Vol. 14 Issue 1/2, p61; Subject Term: Immunohistochemistry; Subject Term: Ear diseases; Author-Supplied Keyword: BrdU (bromodeoxyuridine); Author-Supplied Keyword: Ear swelling; Author-Supplied Keyword: Lymph node; Author-Supplied Keyword: MEST; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S1382-6689(03)00025-5
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - James J. Chen
AU - Yi-Ju Chen
AU - Linda K. Teuschler
AU - Glenn Rice
AU - Karen Hamernik
AU - Alberto Protzel
AU - Ralph L. Kodell
T1 - Cumulative risk assessment for quantitative response data.
JO - Environmetrics
JF - Environmetrics
Y1 - 2003/06//
VL - 14
IS - 4
M3 - Article
SP - 339
EP - 353
SN - 11804009
AB - The Relative Potency Factor approach (RPF) is used to normalize and combine different toxic potencies among a group of chemicals selected for cumulative risk assessment. The RPF method assumes that the slopes of the doseresponse functions are all equal; but this method depends on the choice of the index chemical, i.e. different index chemicals will give different predicted mean estimates. This article is part of an approach to explore and develop cumulative risk assessment strategies. As part of this approach this article proposes a procedure for cumulative risk assessment from exposure to multiple chemicals that have a common mechanism of toxicity. We propose two classification algorithms to cluster the chemicals into subclasses such that the chemicals in the same subclass have a common slope. The joint response is estimated by fitting the doseresponse model of the mixture under dose addition. The proposed method will give the same predicted mean response regardless of the selection of the index chemical for the chemicals in the same subclass. The proposed method also allows one to estimate the joint response for chemicals having different slopes. An example data set of six hypothetical pesticide chemicals is used to illustrate the proposed procedure. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmetrics is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pesticides
KW - Risk assessment
KW - Experimental toxicology
KW - Chemicals
N1 - Accession Number: 20041200; James J. Chen 1; Yi-Ju Chen 1; Linda K. Teuschler 2; Glenn Rice 2; Karen Hamernik 3; Alberto Protzel 3; Ralph L. Kodell 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, U.S.A.; 2: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH 45268, U.S.A.; 3: Health Effects Division, Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC 20460, U.S.A.; Issue Info: Jun2003, Vol. 14 Issue 4, p339; Thesaurus Term: Pesticides; Thesaurus Term: Risk assessment; Thesaurus Term: Experimental toxicology; Subject Term: Chemicals; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Collins, Thomas F.X.
AU - Sprando, Robert L.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Wiesenfeld, Paddy W.
AU - Babu, Uma S.
AU - Bryant, Mark
AU - Flynn, Thomas J.
AU - Ruggles, Dennis I.
T1 - Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2003/06//
VL - 41
IS - 6
M3 - Article
SP - 819
SN - 02786915
AB - Flaxseed, a rich source of reportedly beneficial n-3 fatty acid and phytoestrogens, has not been thoroughly tested for reproductive effects. High levels of flaxseed (FS, 20 or 40%) or defatted flaxseed meal (FLM, 13 or 26%) added to AIN-93 diet were evaluated in a two-phase study: dosed during gestation only or during gestation and maturation in a lifetime study. At cesarean section on gestation day 20, neither FS nor FLM affected fertility, body weight gain, litter size, or fetal development. FLM, but not FS, decreased gestation length. The offspring of dams allowed to litter were observed to postnatal day (PND) 21 or 90. Neither FS nor FLM affected PND 21 survival indices of F1 pups. FS (20 and 40%), but not FLM, increased the anogenital index (AGI) of F1 females at PND 21. The AGI of F1 males was not affected by either FS or FLM. FLM (13 and 26%), but not FS, delayed puberty in F1 males. Age and weight at the onset of puberty in females were not affected by FS or FLM. FS and FLM caused dose-related increases in the number of F1 females with irregular estrous cycles. During PND 21-90, F1 females fed 20% FS, 13% FLM, or 26% FLM gained more weight than the controls. FS and FLM decreased thymus/body weight and thymus/brain weight ratios in weanling F1 males and females. FS and FLM decreased liver/body weight and liver/brain weight ratios in weanling F1 females, and 26% FLM decreased the same two ratios in F1 males. In conclusion, FS did not affect fetal development but did affect indices of postnatal development such as the estrous cycle. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAXSEED
KW - DIETARY supplements
KW - RATS -- Physiology
KW - ANIMAL nutrition
KW - analysis of covariance (ANCOVA)
KW - analysis of variance (ANOVA)
KW - anogenital index (AGI)
KW - Development
KW - Dietary supplement
KW - Flaxseed
KW - flaxseed (FS)
KW - flaxseed meal (FLM)
KW - gestation day (GD)
KW - least significant difference. (LSD)
KW - postnatal day (PND)
KW - Rat
KW - Reproduction
N1 - Accession Number: 9655222; Collins, Thomas F.X.; Email Address: tfc@cfsan.fda.gov Sprando, Robert L. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Wiesenfeld, Paddy W. 1 Babu, Uma S. 1 Bryant, Mark 1 Flynn, Thomas J. 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jun2003, Vol. 41 Issue 6, p819; Subject Term: FLAXSEED; Subject Term: DIETARY supplements; Subject Term: RATS -- Physiology; Subject Term: ANIMAL nutrition; Author-Supplied Keyword: analysis of covariance (ANCOVA); Author-Supplied Keyword: analysis of variance (ANOVA); Author-Supplied Keyword: anogenital index (AGI); Author-Supplied Keyword: Development; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: Flaxseed; Author-Supplied Keyword: flaxseed (FS); Author-Supplied Keyword: flaxseed meal (FLM); Author-Supplied Keyword: gestation day (GD); Author-Supplied Keyword: least significant difference. (LSD); Author-Supplied Keyword: postnatal day (PND); Author-Supplied Keyword: Rat; Author-Supplied Keyword: Reproduction; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 111120 Oilseed (except Soybean) Farming; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/S0278-6915(03)00033-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flynn, T.J.
AU - Collins, T.F.X.
AU - Sprando, R.L.
AU - Black, T.N.
AU - Ruggles, D.I.
AU - Wiesenfeld, P.W.
AU - Babu, U.S.
T1 - Developmental effects of serum from flaxseed-fed rats on cultured rat embryos
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2003/06//
VL - 41
IS - 6
M3 - Article
SP - 835
SN - 02786915
AB - Gestation day 9.5 rat embryos were cultured for 45 h in serum obtained from pregnant rats that had been fed throughout gestation with either a control diet (based on the AIN-93 formulation), a diet supplemented with flaxseed (20% or 40%, w/w), or a diet supplemented with de-fatted flaxseed (“flaxseed meal”, 13 or 26%, w/w). The embryos were fixed in neutral formalin at the end of culture. Overall growth and development was assessed, and the presence of abnormalities was noted. A significant inhibition of growth (as determined by crown-rump length) relative to control was observed in embryos cultured in serum from rats fed the 20% flaxseed diet. The incidence of spontaneous heart inversions was increased significantly in the embryos cultured in serum from the 20% flaxseed and 26% flaxseed meal fed rats. The incidence of flexion defects was increased significantly in embryos cultured in serum from 20% flaxseed-fed rats. The lack of an apparent dose response in any of the statistically significant effects suggests that the observed anomalies were chance occurrences unrelated to the treatment group from which serum was obtained. It is therefore concluded that diets high in flaxseed or flaxseed meal do not result in serum factors that are directly embryotoxic to organogenesis-staged rat embryos. This finding is consistent with the findings of a parallel in vivo rat teratology study where no significant embryotoxicity attributable to flaxseed exposure was observed. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAXSEED
KW - RATS -- Reproduction
KW - PREGNANCY in animals
KW - Embryotoxicity
KW - Flaxseed
KW - In vitro
N1 - Accession Number: 9655223; Flynn, T.J. 1; Email Address: tflynn@cfsan.fda.gov Collins, T.F.X. 1 Sprando, R.L. 1 Black, T.N. 1 Ruggles, D.I. 2 Wiesenfeld, P.W. 1 Babu, U.S. 1; Affiliation: 1: Offices of Applied Research and Safety Assessment, FDA, MOD-1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Scientific Analysis and Support, US FDA, Center for Food Safety and Applied Nutrition, MOD-1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jun2003, Vol. 41 Issue 6, p835; Subject Term: FLAXSEED; Subject Term: RATS -- Reproduction; Subject Term: PREGNANCY in animals; Author-Supplied Keyword: Embryotoxicity; Author-Supplied Keyword: Flaxseed; Author-Supplied Keyword: In vitro; NAICS/Industry Codes: 111120 Oilseed (except Soybean) Farming; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0278-6915(03)00034-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9655223&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wiesenfeld, P.W.
AU - Babu, U.S.
AU - Collins, T.F.X.
AU - Sprando, R.
AU - O'Donnell, M.W.
AU - Flynn, T.J.
AU - Black, T.
AU - Olejnik, N.
T1 - Flaxseed increased α-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring☆☆ This research on flaxseed and flaxseed meal is not an endorsement for the products by the US Food and Drug Administration.
PB - Elsevier Public Safety
SN - 0197-2510
AD - Indian Health Service, Crow Indian Reservation, Montana; upchurch@mcn.net
U2 - PMID: 12792597.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wagner, R.D.
AU - Paine, D.D.
AU - Cerniglia, C.E.
T1 - Phenotypic and genotypic characterization of competitive exclusion products for use in poultry.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2003/06//
VL - 94
IS - 6
M3 - Article
SP - 1098
EP - 1107
PB - Wiley-Blackwell
SN - 13645072
AB - Abstract Aims: Phenotypic and genotypic bacteria identification methods were compared for their efficacy in determining the composition of competitive exclusion (CE) products. Methods and Results: Phenotypic methods used for bacterial identification were fatty acid methyl ester profiles, biochemical assays and carbohydrate utilization profiles. Genotypic methods were MicroSeq16S rRNA sequence analysis and BLAST searches of the GenBank sequence database. Agreement between phenotypic and genotypic methods for identification of bacteria isolated from the Preempt CE product was 20%. A defined test mixture of bacteria was identified to the species level 100% by BLAST analysis, 64% by MicroSeq and 36% by phenotypic techniques. Conclusions: The wide range of facultative and obligate anaerobic bacteria present in a CE product are more accurately identified with 16S rRNA sequence analyses than with phenotypic identification techniques. Significance and Impact of the Study: These results will provide guidelines for manufacturers of CE products to submit more reliable product information for market approval by regulatory agencies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poultry
KW - Veterinary microbiology
KW - Identification of bacteria
KW - 16S rRNA
KW - anaerobic
KW - competitive exclusion
KW - food safety
KW - genotypic
KW - Microbial identification
KW - phenotypic
KW - poultry
N1 - Accession Number: 9749591; Wagner, R.D. 1; Paine, D.D. 1; Cerniglia, C.E. 1; Affiliations: 1: Microbiology Division, FDA National Center for Toxicological Research, Jefferson, AR, USA; Issue Info: Jun2003, Vol. 94 Issue 6, p1098; Thesaurus Term: Poultry; Thesaurus Term: Veterinary microbiology; Subject Term: Identification of bacteria; Author-Supplied Keyword: 16S rRNA; Author-Supplied Keyword: anaerobic; Author-Supplied Keyword: competitive exclusion; Author-Supplied Keyword: food safety; Author-Supplied Keyword: genotypic; Author-Supplied Keyword: Microbial identification; Author-Supplied Keyword: phenotypic; Author-Supplied Keyword: poultry; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1046/j.1365-2672.2003.01944.x
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Ershow, Abby G.
T1 - Research science, regulatory science, and nutrient databases: achieving an optimal convergence Capstone Lecture
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2003/06//
VL - 16
IS - 3
M3 - Editorial
SP - 255
SN - 08891575
AB - The compelling practical applications of nutrient databases, and the technical challenges in their development, often divert attention from their underlying research basis. Nutrient databases are, in fact, the publications of research projects that draw on the methodology of analytical chemistry, sampling statistics, and information technology in order to answer a core question: “What is the nutrient content of the food supply?” The responsibility for addressing this question, and for conducting the ensuing research, is typically assigned to governmental entities, especially for databases that are reflective of national food supplies. This responsibility reflects the key role of nutrient data in public health decision-making.At their best, nutrient databases can represent an optimal convergence of the characteristics of both “research science,” which seeks to increase knowledge of natural phenomena and processes, and “regulatory science,” which provides the knowledge base needed for policy-making and other government work. These two categories of research have many commonalities, such as their scientific methodology, even though they differ in their sites of performance and affiliated institutions, their operational procedures, and their standards of accountability. A good example of this convergence is found in the National Food and Nutrient Analysis Program and its various ancillary projects (databases on fluoride, choline, phytonutrients, Native American/Alaska Native foods, commodity foods, and dietary supplements). Confirmed validity of the findings, enhanced trust in the results, strengthened political and public support, and funding that underwrites the capacity for high scientific standards, are all potential benefits of acknowledging the simultaneous research and regulatory science aspects of nutrient databases. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRIENT cycles
KW - INFORMATION technology
KW - Food composition research
KW - National Food and Nutrient Analysis Program
KW - Nutrient databases
KW - Peer review
KW - Regulatory science
N1 - Accession Number: 9905408; Ershow, Abby G. 1; Email Address: ershowa@nih.gov; Affiliation: 1: Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 6701 Rockledge Drive, Suite 10-193, MSC 7956, Bethesda, MD 20892-7956, USA; Source Info: Jun2003, Vol. 16 Issue 3, p255; Subject Term: NUTRIENT cycles; Subject Term: INFORMATION technology; Author-Supplied Keyword: Food composition research; Author-Supplied Keyword: National Food and Nutrient Analysis Program; Author-Supplied Keyword: Nutrient databases; Author-Supplied Keyword: Peer review; Author-Supplied Keyword: Regulatory science; Number of Pages: 14p; Document Type: Editorial
L3 - 10.1016/S0889-1575(03)00054-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brandt, Mary Bender
AU - LeGault, Lori A.
T1 - What's new on nutrition labeling at the United States Food and Drug Administration?
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2003/06//
VL - 16
IS - 3
M3 - Article
SP - 383
SN - 08891575
AB - The manuscript provides an overview of food labeling activities of the United States (USA) Food and Drug Administration (FDA). Highlights include:FDA will proceed with final rulemaking on trans fatty acid labeling after review of the National Academy of Sciences (NAS) Macronutrient Report. FDA, United States Department of Agriculture (USDA), and Health Canada are funding a 24-month NAS study on Dietary Reference Intakes in Nutrition Labeling to provide information that can be considered in the development of reference values for labeling in the USA and Canada. In March of 2002, FDA published a rule that proposes to amend the regulations to update the names and nutrition labeling values of the 20 most frequently consumed raw fruits, vegetables, and fish in the USA and to revise the guidelines for the voluntary nutrition labeling of these raw foods. For over 20 years, FDA has used the Food Label and Package Survey (FLAPS) to monitor the industry response to food label regulations. FLAPS is the only large-scale USA survey that routinely reviews food label information representative of the nation''s food supply. Nutrition labeling databases are collections of nutrient data for specific products or commodities used to support nutrition label values. While selection of the source of the data used to calculate nutrition labeling values is the prerogative of the manufacturer, FDA recommends that the nutrient values for nutrition labeling be based on product composition as determined by laboratory analysis. Restaurants using claims must provide nutrition information relevant to the claim and may determine nutrient levels by nutrient databases, cookbooks, analyses, and by other reasonable bases that provide assurance that the food or meal meets the nutrient requirements for a claim. 2.0±0.4 μM FEN were reached within 40 min after the first dose of FEN, and then declined rapidly, while peak plasma levels (0.4±0.1 μM) of the metabolite norfenfluramine (NFEN) were not reached until 6 h after dosing. After the seventh (next to last) dose of FEN, peak plasma levels of FEN were 35% greater than after the first dose while peak NFEN-levels were 500% greater. The t1/2 for FEN was 2.6±0.3 h after the first dose and 3.2±0.2 h after the seventh. The estimated t1/2 for NFEN was more than 37.6±20.5 h. Peak plasma levels of 9.5±2.5 μM MDMA were reached within 20 min after the first dose of MDMA, and then declined rapidly, while peak plasma levels (0.9±0.2 μM) of the metabolite 3,4-methylenedioxyamphetamine (MDA) were not reached until 3–6 h after dosing. After the seventh (next to last) dose of MDMA, peak plasma levels of MDMA were 30% greater than the first dose while peak MDA levels were elevated over 200%. The t1/2 for MDMA was 2.8±0.4 h after the first and 3.9±1.1 h after the seventh dose. The estimated t1/2 for MDA was about 8.3±1.0 h. Variability in plasma levels of MDMA and MDA between subjects was much greater than that for FEN and NFEN. This variability in MDMA and MDA exposure levels may have lead to variability in the subsequent disruption of some behaviors seen in these same subjects. There were 80% reductions in the plasma membrane-associated 5-HT transporters 6 months after either the FEN or MDMA dosing regimen indicating that both treatments produced long-term serotonergic effects. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - ECSTASY (Drug)
KW - SEROTONIN uptake inhibitors
KW - CELL membranes
KW - FENFLURAMINE
KW - Behavior and neurotoxicity
KW - Ecstasy
KW - Fenfluramine
KW - Methylenedioxymethamphetamine
KW - Pharmacokinetics
KW - Primates
N1 - Accession Number: 9853952; Bowyer, John F. 1; Email Address: jbowyer@nctr.fda.gov Young, John F. 1 Slikker Jr., William 1 Itzak, Yossef 2 Mayorga, A.J. 1 Newport, Glenn D. 1 Ali, Syed F. 1 Frederick, David L. 3 Paule, Merle G. 1; Affiliation: 1: Division of Neurotoxicology and Biometry and Risk Assessment, National Center for Toxicological Research/FDA, Jefferson, AR 72079-9502, USA 2: Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL 33136, USA 3: Glaxo Wellcome, Research Triangle Park, NC 27516, USA; Source Info: Jun2003, Vol. 24 Issue 3, p379; Subject Term: METABOLITES; Subject Term: ECSTASY (Drug); Subject Term: SEROTONIN uptake inhibitors; Subject Term: CELL membranes; Subject Term: FENFLURAMINE; Author-Supplied Keyword: Behavior and neurotoxicity; Author-Supplied Keyword: Ecstasy; Author-Supplied Keyword: Fenfluramine; Author-Supplied Keyword: Methylenedioxymethamphetamine; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Primates; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S0161-813X(03)00030-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106623437
T1 - Economic analysis of promotion of hepatitis B vaccinations among Vietnamese-American children and adolescents in Houston and Dallas.
AU - Zhou F
AU - Euler GL
AU - McPhee SJ
AU - Nguyen T
AU - Lam T
AU - Wong C
AU - Mock J
Y1 - 2003/06//Jun2003 Part 1 of 3
N1 - Accession Number: 106623437. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Supplement Title: Jun2003 Part 1 of 3. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: CDC under Cooperative Agreement U66/CCU915175. NLM UID: 0376422.
KW - Health Promotion -- Economics
KW - Hepatitis B Vaccines -- Economics
KW - Hepatitis B -- Prevention and Control -- In Infancy and Childhood
KW - Immunization Programs -- Economics
KW - Vietnamese -- In Infancy and Childhood -- Texas
KW - Adolescence
KW - Child
KW - Child, Preschool
KW - Community-Institutional Relations -- Economics
KW - Cost Benefit Analysis
KW - Cost Benefit Analysis -- Methods
KW - Funding Source
KW - Immunization
KW - Multimedia -- Economics
KW - Texas
KW - United States
KW - Vietnam -- Ethnology
KW - Human
SP - 1289
EP - 1296
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 111
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To ascertain the cost-effectiveness and benefit-cost ratios of 2 public health campaigns conducted in Dallas and Houston in 1998-2000 for 'catch-up' hepatitis B vaccination of Vietnamese-Americans born 1984-1993. DESIGN: Program evaluation. SETTING: Houston and Dallas, Texas. PARTICIPANTS: A total of 14,349 Vietnamese-American children and adolescents. INTERVENTIONS: Media-led information and education campaign in Houston, and community mobilization strategy in Dallas. Outcomes were compared with a control site: Washington, DC. MAIN OUTCOME MEASURES: Receipt of 1, 2, or 3 doses of hepatitis B vaccine before and after the interventions, costs of interventions, cost-effectiveness ratios for intermediate outcomes, intervention cost per discounted year of life saved, and benefit-cost ratio of the interventions. RESULTS: The number of children who completed the series of 3 hepatitis B vaccine doses increased by 1176 at a total cost of 313,904 dollars for media intervention, and by 390 and at 169,561 dollars for community mobilization. Costs per child receiving any dose, per dose, and per completed series were 363 dollars, 101 dollars, and 267 dollars for media intervention and 387 dollars, 136 dollars, and 434 dollars for community mobilization, respectively. For media intervention, the intervention cost per discounted year of life saved was 9954 dollars and 131 years of life were saved; for community mobilization, estimates were 11,759 dollars and 60 years of life. The benefit-cost ratio was 5.26:1 for media intervention and 4.47:1 for community mobilization. CONCLUSION: Although the increases in the number of children who completed series of 3 doses were modest for both the Houston and Dallas areas, both media education and, to a lesser degree, community mobilization interventions proved cost-effective and cost-beneficial.
SN - 0031-4005
AD - National Immunization Program, CDC, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333; faz1@cdc.gov
U2 - PMID: 12777543.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106623454
T1 - Patient safety events during pediatric hospitalizations.
AU - Miller MR
AU - Elixhauser A
AU - Zhan C
Y1 - 2003/06//Jun2003 Part 1 of 3
N1 - Accession Number: 106623454. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Jun2003 Part 1 of 3. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Intramural research funds of the AHRQ. NLM UID: 0376422.
KW - Adverse Health Care Event -- Prevention and Control
KW - Child Safety
KW - Child, Hospitalized
KW - Adolescence
KW - Adult
KW - Algorithms
KW - Birth Injuries -- Epidemiology
KW - Child
KW - Child, Preschool
KW - Clinical Indicators
KW - Clinical Indicators -- Economics
KW - Comparative Studies
KW - Diagnosis-Related Groups
KW - Diagnosis-Related Groups -- Economics
KW - Funding Source
KW - Hospital Mortality -- Trends
KW - Hospitals, Pediatric -- Economics
KW - Infant
KW - Infant, Newborn
KW - Inpatients
KW - International Classification of Diseases
KW - Length of Stay
KW - Length of Stay -- Economics
KW - Logistic Regression
KW - Multivariate Analysis
KW - Record Review
KW - Safety -- Economics
KW - Treatment Errors
KW - Human
SP - 1358
EP - 1366
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 111
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: Our objective was to describe potential patient safety events for hospitalized children, using the patient safety indicators (PSIs), and examine associations with these events. METHODS: PSI algorithms, developed by researchers at the Agency for Healthcare Research and Quality to identify potential in-hospital patient safety problems using administrative data, were applied to 3.8 million discharge records for children under 19 years from 22 states in the 1997 Healthcare Cost and Utilization Project. Prevalence of PSI events and associations with patient-level and hospital-level characteristics, length of stay, in-hospital mortality, and total charges were examined. RESULTS: The prevalence of pediatric patient safety events is significant with the highest rate found for birth trauma at 1.5 cases per every 100 births. The majority of these events for birth trauma consist of long bone and skull fractures, excluding the clavicle. Compared with records without PSI events, discharges with PSI events had 2- to 6-fold longer lengths of stay, 2- to 18-fold higher rates of in-hospital mortality, and 2- to 20-fold higher total charges. Bivariate and multivariate analyses found that all PSI events except birth trauma were directly associated with factors related to greater severity of illness and large urban teaching institutions. Birth trauma, however, was directly associated with black and Hispanic ethnicity but was not consistently associated with technologically sophisticated teaching institutions. CONCLUSIONS: The prevalence of birth trauma and other potential patient safety events for hospitalized children is high and comparable to hospitalized adults. These events are associated with increased length of stay, in-hospital mortality, and total charges. Associated factors differ significantly for birth trauma compared with other PSI events. Institutional application of the PSIs may be useful to identify processes of care that warrant further evaluation as the health care industry tackles the problem of patient safety, particularly for children.
SN - 0031-4005
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, Maryland; mmille21@jhmi.edu
U2 - PMID: 12777553.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Paul J. Seligman
T1 - Dear doctor
Evaluating the impact of risk communication efforts(This article is a US Government work and is in the public domain in the USA.).
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2003/06//
VL - 12
IS - 4
M3 - Article
SP - 291
SN - 10538569
N1 - Accession Number: 11119697; Paul J. Seligman 1; Affiliations: 1: Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, USA; Issue Info: Jun2003, Vol. 12 Issue 4, p291; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Venn, Sally
AU - Edwards, Adrian
T1 - Assessing the awareness of and attitude to NICE guidance within GP partnerships in one PCO in Wales: a qualitiative study using focus group interviews.
JO - Quality in Primary Care
JF - Quality in Primary Care
Y1 - 2003/06//
VL - 11
IS - 2
M3 - Article
SP - 123
EP - 128
PB - Radcliffe Publishing
SN - 14791072
AB - Background Guidelines from the National Institute for Clinical Excellence (NICE) have taken on a special prominence in the UK National Health Service (NHS). Many of these apply to primary care but there are few data available about general practitioners' attitudes to and practical arrangements for implementing NICE guidance. Aim To explore GPs' attitudes to practice policies and practical arrangements the implementing NICE guidance. Method Practice-based focus group interviews. Setting One primary care organisation in South Wales. Results A total of 36 doctors (62% of the sample) were interviewed, including at least one member from each of the 14 practices in the study'. There were high levels of awareness of NICE guidance, but few procedures for dissemination and implementation within practices. The guidance publications were often felt to be of limited practical benefit to professionals who were largely concerned with providing high-quality care individuals. Conclusions These findings may represent significant obstacles to the implementation of NICE guidance and thus limit their scope to enhance the clinical governance agenda in the UK NHS. The obstacles must: be addressed in ways that enhance not burden current clinical activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Quality in Primary Care is the property of Radcliffe Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSICIANS (General practice)
KW - PRIMARY care (Medicine)
KW - MEDICAL care
KW - PUBLIC health
KW - CLINICAL medicine
KW - ATTITUDES
KW - GREAT Britain
KW - Gp
KW - guidance
KW - NICE.
KW - partnerships
KW - GREAT Britain. National Health Service
N1 - Accession Number: 12179462; Venn, Sally 1; Email Address: sally.venn@nphs.wales.nhs.uk Edwards, Adrian 2,3; Affiliation: 1: National Public Health Service for Wales, Pontypool, South Wales, UK. 2: Department of Primary Care, University of Wales Swansea Clinical School. 3: Torfaen Local Health Group, Pontypool, UK.; Source Info: Jun2003, Vol. 11 Issue 2, p123; Subject Term: PHYSICIANS (General practice); Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: CLINICAL medicine; Subject Term: ATTITUDES; Subject Term: GREAT Britain; Author-Supplied Keyword: Gp; Author-Supplied Keyword: guidance; Author-Supplied Keyword: NICE.; Author-Supplied Keyword: partnerships; Company/Entity: GREAT Britain. National Health Service; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106874069
T1 - Assessing the awareness of and attitude to NICE guidance within GP partnerships in one PCO in Wales: a qualitative study using focus group interviews.
AU - Venn S
AU - Edwards A
Y1 - 2003/06//
N1 - Accession Number: 106874069. Language: English. Entry Date: 20050425. Revision Date: 20150820. Publication Type: Journal Article; research. Journal Subset: Editorial Board Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 101182136.
KW - Primary Health Care -- Wales
KW - Physician Attitudes
KW - Practice Guidelines
KW - Wales
KW - Qualitative Studies
KW - Focus Groups
KW - Semi-Structured Interview
KW - Physicians, Family
KW - Female
KW - Male
KW - Grounded Theory
KW - Health Knowledge
KW - National Health Programs
KW - Clinical Governance
KW - Questionnaires
KW - Human
SP - 123
EP - 128
JO - Quality in Primary Care
JF - Quality in Primary Care
JA - QUAL PRIM CARE
VL - 11
IS - 2
PB - Radcliffe Publishing
SN - 1479-1072
AD - Specialist Registrar, National Public Health Service for Wales, Mamhilad Park Estate, Pontypool, South Wales, UK; sally.venn@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chang, Cheng-Nan
AU - Chu, Chia-Chium
AU - Wu, Yuh-Shen
AU - Fu, Peter Pi-Cheng
AU - Yang, I-Lin
AU - Chen, Ming-Hsiang
T1 - Characterization of particulate, metallic elements of TSP, PM2.5 and PM2.5-10 aerosols at a farm sampling site in Taiwan, Taichung
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2003/06//
VL - 308
IS - 1-3
M3 - Article
SP - 157
SN - 00489697
AB - Atmospheric aerosol particles and metallic concentrations were monitored at the Experimental Farm of Tunghai University (EFTU) sampling site in this study. Total suspended particulate matter (TSP) was collected by using a PS-1 sampler at the farm-sampling site, in central Taiwan, from July 2001 to April 2002. At the same time, PM2.5 and PM2.5–10 were also measured with a Universal sampler from January 2002 to April 2002. Only subjects with the most complete data records on TSP sampling (N=43) and PM10 sampling (N=23) were used in this analysis. Taichung Industrial Park, Taichung Kang Road (traffic) and a Hospital Incinerator surround the Experimental Farm of Tunghai University. Atmospheric concentrations of metallic elements were analyzed by a flame atomic absorption spectrophotometer (AA-680/G). The results indicated that the metallic elements Mg, Cu and Mn were the largest components in the TSP fraction; the metallic elements Fe and Cd were the largest composition in the PM2.5–10 fraction; however, the metallic elements Pb, Zn, Cr and Ni were the largest abundance in the PM2.5 fraction. The atmospheric metallic elements in the TSP, PM2.5 and PM2.5–10 fractions came different emission sources, such as soil, traffic, industry and resuspended particles. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALLIC composites
KW - SPECTROPHOTOMETRY
KW - Heavy metal
KW - PCA
KW - PM2.5
KW - PM2.5-10
KW - TSP
N1 - Accession Number: 9656244; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw Chang, Cheng-Nan 2 Chu, Chia-Chium 3 Wu, Yuh-Shen 1 Fu, Peter Pi-Cheng 4 Yang, I-Lin 2 Chen, Ming-Hsiang 2; Affiliation: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang Institute of Technology, Sha-Lu, Taichung 433, Taiwan, ROC 2: Department of Environmental Science, Tunghai University Taichung 407, Taiwan, ROC 3: The Chief of Intensive Care Unit, Department of Internal Medicine, Intensive Care Unit, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan, ROC 4: Division of Biochemical Toxicology National Center, for Toxicological Research Jefferson, AK 72079, USA; Source Info: Jun2003, Vol. 308 Issue 1-3, p157; Subject Term: METALLIC composites; Subject Term: SPECTROPHOTOMETRY; Author-Supplied Keyword: Heavy metal; Author-Supplied Keyword: PCA; Author-Supplied Keyword: PM2.5; Author-Supplied Keyword: PM2.5-10; Author-Supplied Keyword: TSP; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0048-9697(02)00648-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106669405
T1 - Using qualitative methods to design an epidemiologic study on sexually transmitted diseases in female prisoners.
AU - Newman SB
AU - Girasek DC
AU - Friedman H
Y1 - 2003/06//
N1 - Accession Number: 106669405. Language: English. Entry Date: 20041126. Revision Date: 20150711. Publication Type: Journal Article; letter; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by a grant from the Uniformed Services University of the Health Sciences. NLM UID: 7705941.
KW - Epidemiological Research
KW - Prisoners
KW - Questionnaires -- Standards
KW - Sexually Transmitted Diseases -- Epidemiology
KW - Adult
KW - Female
KW - Focus Groups
KW - Funding Source
KW - Instrument Construction
KW - Interviews
KW - Maryland
KW - Reproducibility of Results
KW - Study Design
KW - Women's Health
KW - Human
SP - 531
EP - 532
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 30
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Epidemiologist Division of Immigration Health Services, United States Public Health Service, 1220 L Street NW, Washington DC 20005
U2 - PMID: 12782959.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Barrett, W.L.
AU - Garber, S.M.
T1 - Surgical smoke: a review of the literature.
JO - Surgical Endoscopy
JF - Surgical Endoscopy
Y1 - 2003/06//
VL - 17
IS - 6
M3 - Article
SP - 979
EP - 987
SN - 09302794
AB - Surgical smoke is omnipresent in the day-to-day life of the surgeon and other medical personnel who work in the operating room. In addition, patients are also exposed, especially and uniquely so in laparoscopic cases where smoke is created and trapped in a closed and absorptive space. Surgical smoke has typically been produced by electrocautery but is now ever more present in a new form with the burgeoning use of the laser and the harmonic scalpel. Several cases of transmission of human papillomavirus (HPV) from patient to treating professional via laser smoke have alerted us to the reality that surgical smoke in certain situations is far form benign. However, surgeons rarely take measures to protect themselves, their co-coworkers and patients from surgical smoke. Should we and, if so, how do we differentiate between different types of smoke and should we move toward increasing our efforts to protect ourselves, our co-workers, and patients from it? This article attempts to sort through the available data and draw some reasonable conclusions regarding surgical smoke. In general, surgical smoke is a biohazard and cannot be ignored. At a minimum, surgical smoke is a toxin similar to cigarette smoke. However, other dangers exist. This is especially true in specific curcumstances such as when tissue infected with dangerous viruses is aerosolized by lasers. In addition, smoke generated by the harmonic scalpel, being a relatively cold vapor similar to laser smoke, should be further investigated for its potential ill effects and until then, looked upon with reasonable caution. Although not a high-priority in most surgical cases, surgeons should support efforts to minimize OR personnel, patients, and their own exposure to surgical smoke. [ABSTRACT FROM AUTHOR]
AB - Copyright of Surgical Endoscopy is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPERATING room personnel
KW - SURGERY
KW - MEDICAL care
KW - PAPILLOMAVIRUS diseases -- Transmission
KW - NOSOCOMIAL infections
KW - SMOKE
KW - TRANSMISSION
KW - Electrocautery
KW - Harmonic scalpel
KW - Laser
KW - Occupational hazards
KW - Tissue ablation
N1 - Accession Number: 16655012; Barrett, W.L. 1 Garber, S.M. 2; Affiliation: 1: Indian Health Service, Ada, OK 74820, USA 2: Long Island Institute for Minimally Invasive Surgery, 488 Great Neck Road, Suite 300, Great Neck, NY 11021, USA; Source Info: Jun2003, Vol. 17 Issue 6, p979; Subject Term: OPERATING room personnel; Subject Term: SURGERY; Subject Term: MEDICAL care; Subject Term: PAPILLOMAVIRUS diseases -- Transmission; Subject Term: NOSOCOMIAL infections; Subject Term: SMOKE; Subject Term: TRANSMISSION; Author-Supplied Keyword: Electrocautery; Author-Supplied Keyword: Harmonic scalpel; Author-Supplied Keyword: Laser; Author-Supplied Keyword: Occupational hazards; Author-Supplied Keyword: Tissue ablation; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s00464-002-8584-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MacGregor, J. T.
T1 - SNPs and Chips: Genomic Data in Safety Evaluation and Risk Assessment.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/06//
VL - 73
IS - 2
M3 - Article
SP - 207
EP - 208
PB - Oxford University Press / USA
SN - 10966080
AB - The article discusses various reports published within the issue including the workshop on toxicogenomics and risk assessment, the occurrence of single nucleotide polymorphisms and the potential to exploit proteomic and metabonomic technologies to develop improved serum markers of cellular injury.
KW - Toxicogenomics
KW - Blood plasma
N1 - Accession Number: 20606191; MacGregor, J. T. 1; Affiliations: 1: FDA National Center For Toxicological Research, Rockville, MD 20857; Issue Info: Jun2003, Vol. 73 Issue 2, p207; Thesaurus Term: Toxicogenomics; Subject Term: Blood plasma; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 2p; Document Type: Article
L3 - 10.1093/toxsci/kfg099
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Goering, Peter L.
T1 - The Road to Elucidating the Mechanism of Manganese-Bilirubin-Induced Cholestasis.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/06//
VL - 73
IS - 2
M3 - Article
SP - 216
EP - 219
PB - Oxford University Press / USA
SN - 10966080
AB - The article highlighted in this issue is "Synergistic Role of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Cholesterol 7&agr;-Hydroxylase in the Pathogenesis of Manganese-Bilirubin-Induced Cholestasis in Rats," by Marie-Yvonne Akoume, Shahid Perwaiz, Ibrahim M. Yousef, and Gabriel L. Plaa (pp. 331-338). [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cholestasis
KW - Cholesterol hydroxylase
KW - Coenzymes
KW - Rats as laboratory animals
KW - Bile pigments
KW - Bilirubin
N1 - Accession Number: 20606208; Goering, Peter L. 1; Email Address: plg@cdrh.fda.gov; Affiliations: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20852; Issue Info: Jun2003, Vol. 73 Issue 2, p216; Subject Term: Cholestasis; Subject Term: Cholesterol hydroxylase; Subject Term: Coenzymes; Subject Term: Rats as laboratory animals; Subject Term: Bile pigments; Subject Term: Bilirubin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1093/toxsci/kfg112
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shankar, Kartik
AU - Vaidya, Vishal S.
AU - Apte, Udayan M.
AU - Manautou, Jose E.
AU - Ronis, Martin J. J.
AU - Bucci, Thomas J.
AU - Mehendale, Harihara M.
T1 - Type 1 Diabetic Mice Are Protected from Acetaminophen Hepatotoxicity.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/06//
VL - 73
IS - 2
M3 - Article
SP - 220
EP - 234
PB - Oxford University Press / USA
SN - 10966080
AB - Streptozotocin (STZ)-induced diabetic (DB) mice challenged with single ordinarily lethal doses of acetaminophen (APAP), carbon tetrachloride (CCl4), or bromobenzene (BB) were resistant to all three hepatotoxicants. Mechanisms of protection against APAP hepatotoxicity were investigated. Plasma alanine aminotransferase, aspartate aminotransferase, and liver histopathology revealed significantly lower hepatic injury in DB mice after APAP administration. HPLC analysis of plasma and urine revealed lower plasma t1/2, increased volume of distribution (Vd), and increased plasma clearance (CLp) of APAP in the DB mice and no difference in APAP-glucuronide, a major metabolite in mice. Interestingly, covalent binding of 14C-labeled APAP to liver target proteins; arylation of APAP to 58, 56, and 44 kDa acetaminophen binding proteins (ABPs); and glutathione (GSH) depletion in the liver did not differ between nondiabetic (non-DB) and DB mice in spite of downregulated hepatic microsomal CYP2E1 and 1A2 proteins in the DB mice, known to be involved in bioactivation of APAP. Compensatory cell division measured via 3H-thymidine pulse labeling and immunohistochemical staining for proliferating cell nuclear antigen (PCNA) indicated earlier onset of S-phase in the DB mice after exposure to APAP. Antimitotic intervention of liver cell division by colchicine (CLC) after administration of APAP led to significantly higher mortality in the DB mice suggesting a pivotal role of liver cell division and tissue repair in the protection afforded by diabetes. In conclusion, the resistance of DB mice against hepatotoxic and lethal effects of APAP appears to be mediated by a combination of enhanced APAP clearance and robust compensatory tissue repair. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diabetes
KW - Streptozotocin
KW - Antineoplastic antibiotics
KW - Mice as laboratory animals
KW - Acetaminophen
KW - covalent binding
KW - CYP2E1
KW - diabetes
KW - species differences
KW - tissue repair
N1 - Accession Number: 20606209; Shankar, Kartik 1; Vaidya, Vishal S. 1; Apte, Udayan M. 1; Manautou, Jose E. 2; Ronis, Martin J. J. 3; Bucci, Thomas J. 4; Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliations: 1: Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Monroe, Louisiana 71209; 2: Department of Pharmaceutical Sciences, College of Pharmacy, University of Connecticut, Storrs, Connecticut 06269; 3: Arkansas Children's Hospital Research Institute, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202; 4: Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jun2003, Vol. 73 Issue 2, p220; Subject Term: Diabetes; Subject Term: Streptozotocin; Subject Term: Antineoplastic antibiotics; Subject Term: Mice as laboratory animals; Subject Term: Acetaminophen; Author-Supplied Keyword: covalent binding; Author-Supplied Keyword: CYP2E1; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: species differences; Author-Supplied Keyword: tissue repair; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfg059
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sotomayor, Rene E.
AU - Washington, Melissa
AU - Nguyen, Linh
AU - Nyang'anyi, Rahma
AU - Hinton, Dennis M.
AU - Ming Chou
T1 - Effects of Intermittent Exposure to Aflatoxin B1 on DNA and RNA Adduct Formation in Rat Liver: Dose-Response and Temporal Patterns.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/06//
VL - 73
IS - 2
M3 - Article
SP - 329
EP - 338
PB - Oxford University Press / USA
SN - 10966080
AB - We studied the effects of intermittent exposure to aflatoxin B1 (AFB1) on hepatic DNA and RNA adduct formation. Fisher-344 male rats were fed 0.01, 0.04, 0.4, or 1.6 ppm of AFB1 intermittently for 8, 12, 16, and 20 weeks, alternating with 4 weeks of dosing and 4 weeks of rest. Other groups of rats were fed 1.6 ppm of AFB1 continuously for 4, 8, 12, and 16 weeks. Control rats received AFB1-free NIH-31 meal diet. AFB1-DNA and -RNA adducts were measured by HPLC with fluorescence detection. The data are presented as total DNA or RNA adducts. The DNA and RNA adduct levels increased or decreased depending on the cycles of dosing and rest. Rats removed from treatment 1 month after 1 or 2 dosing cycles (8 and 16 weeks of intermittent exposure) showed approximately a twofold decrease in DNA adduct levels and a two- to elevenfold decrease in RNA adduct levels compared with rats euthanized immediately after the last dosing cycle (12 and 20 weeks of intermittent exposure). Our data indicate that DNA and RNA adducts increased linearly, from 0.01 ppm to 1.6 ppm of AFB1 after 12 and 20 weeks of intermittent treatment. A linear dose response was also apparent for DNA but not for RNA adducts after 8 and 16 weeks of treatment. As biomarkers of exposure, AFB1-RNA adducts were three to nine times more sensitive than AFB1-DNA adducts but showed greater variability. These results suggest that binding of AFB1 to hepatic DNA is a linear function of the dose, regardless of the way this is administered. The dose-response relationship for RNA adducts depends on the length of the no-dosing cycles and on the turnover rate of RNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aflatoxins
KW - RNA
KW - Biochemical markers
KW - DNA
KW - Rats as laboratory animals
KW - aflatoxin B1
KW - DNA and RNA adducts
KW - intermittent exposure
KW - liver
KW - rats
N1 - Accession Number: 20606195; Sotomayor, Rene E. 1; Email Address: rsotomay@cfsan.fda.gov; Washington, Melissa 1; Nguyen, Linh 2; Nyang'anyi, Rahma 2; Hinton, Dennis M. 1; Ming Chou 3; Affiliations: 1: Center for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland 20742; 2: Joint Institute for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, University of Maryland, College Park, Maryland 20742; 3: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Jun2003, Vol. 73 Issue 2, p329; Thesaurus Term: Aflatoxins; Thesaurus Term: RNA; Thesaurus Term: Biochemical markers; Subject Term: DNA; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: aflatoxin B1; Author-Supplied Keyword: DNA and RNA adducts; Author-Supplied Keyword: intermittent exposure; Author-Supplied Keyword: liver; Author-Supplied Keyword: rats; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfg076
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20606195&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hinton, Dennis M.
AU - Myers, Michael J.
AU - Raybourne, Richard A.
AU - Francke-Carroll, Sabine
AU - Sotomayor, Rene E.
AU - Shaddock, Joseph
AU - Warbritton, Alan
AU - Chou, Ming W.
T1 - Immunotoxicity of Aflatoxin B1 in Rats: Effects on Lymphocytes and the Inflammatory Response in a Chronic Intermittent Dosing Study.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/06//
VL - 73
IS - 2
M3 - Article
SP - 362
EP - 377
PB - Oxford University Press / USA
SN - 10966080
AB - We investigated the effects of aflatoxin B1 (AFB1) on isolated splenic lymphocytes and the histo-morphologic changes in the spleens and liver of Fisher-344 male rats. Weaned animals were fed chow diets that contained 0, 0.01, 0.04, 0.4, or 1.6 ppm AFB1, using an intermittent dosing regimen (4 weeks on and 4 weeks off AFB1), for 40 weeks. An additional group of animals was fed the 1.6 ppm AFB1 diet continuously. The intermittent dosing regimen was designed to evaluate effects of cumulative dose and exposure for risk assessment comparisons. The percentages of T and B cells were affected as shown by flow cytometric analysis after the dosing cycles. The observed changes appeared to reverse or compensate to some extent after the off cycles. Lymphocytes were stimulated in culture for analysis of the production of IL-2, IL-1, and IL-6. Significantly increased production of IL-1 and IL-6 was seen in the second dosing cycle (12 weeks) and the second "off" cycle (16 weeks) at the higher doses. Inflammatory infiltrates were seen in the liver after eight weeks of continuous and intermittent dosing and were increased in size and number at 12 weeks in both 1.6 ppm dose groups correlating with the peak production of Il-1 and IL-6. We concluded that AFB1 effects on the immune system can be either stimulatory or suppressive dependent on a critical exposure window of dose and time. Immune cells in spleen such as T-lymphocytes and macrophages, both important mediators of inflammatory responses to tissue damage, were affected differently in the continuous and intermittent exposures to AFB1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aflatoxins
KW - Rats as laboratory animals
KW - Immunotoxicology
KW - Lymphoid tissue
KW - Lymphocytes
KW - aflatoxin B1
KW - immunotoxicity
KW - inflammatory response
KW - intermittent dosing
N1 - Accession Number: 20606198; Hinton, Dennis M. 1; Email Address: dhinton@cfsan.fda.gov; Myers, Michael J. 2; Raybourne, Richard A. 1; Francke-Carroll, Sabine 1; Sotomayor, Rene E. 1; Shaddock, Joseph 3; Warbritton, Alan 3; Chou, Ming W. 3; Affiliations: 1: United States Food and Drug Association, Center for Food Safety and Applied Nutrition, Laurel, Maryland 20708; 2: United States Food and Drug Association, Center for Veterinary Medicine, Laurel, Maryland 20708; 3: United States Food and Drug Association, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jun2003, Vol. 73 Issue 2, p362; Thesaurus Term: Aflatoxins; Subject Term: Rats as laboratory animals; Subject Term: Immunotoxicology; Subject Term: Lymphoid tissue; Subject Term: Lymphocytes; Author-Supplied Keyword: aflatoxin B1; Author-Supplied Keyword: immunotoxicity; Author-Supplied Keyword: inflammatory response; Author-Supplied Keyword: intermittent dosing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 16p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfg074
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20606198&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Volpe, D.A.
AU - Warren, M.K.
T1 - Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2003/06//
VL - 17
IS - 3
M3 - Article
SP - 271
SN - 08872333
AB - A battery of clonal assays for myeloid progenitor cells (HPP-CFC, CFU-gemm, CFU-gm, CFU-g) was utilized to evaluate the myelotoxicity of a series of alkylating agents representing the spectrum of clinical times to nadir. Bone marrow aspirates from normal volunteers were incubated with mechlorethamine, busulfan, melphalan, carmustine or lomustine for 1 h and then cultured in methylcellulose with 30% serum and cytokines. There was a concentration-dependent inhibition of colony formation and often a differential toxicity to the myeloid progenitors with the alkylators tested. On a molar basis, mechlorethamine and melphalan were the most toxic of the alkylator drugs to the myeloid precursors. The most sensitive progenitor was CFU-gemm with the lowest inhibitory concentration IC70 concentrations for mechlorethamine, melphalan, carmustine and lomustine. Generally, there was great similarity for drug effects between CFU-g and CFU-gm with overlapping inhibition curves. HPP-CFC proved to be the least sensitive of the progenitors to the toxic actions of the drugs. While there was no correlation between the time to clinical neutropenic nadir and the most sensitive progenitor in the clonal assays, the CFU-gm assay remains a suitable method for determining the myelotoxic potential of cytotoxic agents. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Alkylating agents
KW - Cellular immunity
KW - Cytokines
KW - Immune response -- Regulation
KW - Bone marrow
KW - Alkylators
KW - bone marrow (BM)
KW - Clonal assays
KW - colony-forming unit granulocyte (CFU-g)
KW - colony-forming unit granulocyte-erythroid-macrophage-megakaryocyte (CFU-gemm)
KW - colony-forming unit granulocyte-macrophage (CFU-gm)
KW - fetal bovine serum (FBS)
KW - granulocyte colony stimulating factor (G-CSF)
KW - granulocyte-macrophage colony stimulating factor (GM-CSF)
KW - high proliferative potential colony-forming cell (HPP-CFC)
KW - inhibitory concentration (IC)
KW - Iscove's modified Dulbecco's medium (IMDM)
KW - mononuclear cells (MNC)
KW - Myeloid
KW - Myelotoxicity
KW - Neutropenia
KW - plating efficiency. (PE)
KW - Progenitor cells
N1 - Accession Number: 9854732; Volpe, D.A. 1; Email Address: volpe@cder.fda.gov; Warren, M.K. 2; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, 5600 Fishers Lane, Rockville, MD 20857, USA; 2: Poietic Technologies, Inc., Gaithersburg, MD, USA; Issue Info: Jun2003, Vol. 17 Issue 3, p271; Thesaurus Term: Alkylating agents; Thesaurus Term: Cellular immunity; Subject Term: Cytokines; Subject Term: Immune response -- Regulation; Subject Term: Bone marrow; Author-Supplied Keyword: Alkylators; Author-Supplied Keyword: bone marrow (BM); Author-Supplied Keyword: Clonal assays; Author-Supplied Keyword: colony-forming unit granulocyte (CFU-g); Author-Supplied Keyword: colony-forming unit granulocyte-erythroid-macrophage-megakaryocyte (CFU-gemm); Author-Supplied Keyword: colony-forming unit granulocyte-macrophage (CFU-gm); Author-Supplied Keyword: fetal bovine serum (FBS); Author-Supplied Keyword: granulocyte colony stimulating factor (G-CSF); Author-Supplied Keyword: granulocyte-macrophage colony stimulating factor (GM-CSF); Author-Supplied Keyword: high proliferative potential colony-forming cell (HPP-CFC); Author-Supplied Keyword: inhibitory concentration (IC); Author-Supplied Keyword: Iscove's modified Dulbecco's medium (IMDM); Author-Supplied Keyword: mononuclear cells (MNC); Author-Supplied Keyword: Myeloid; Author-Supplied Keyword: Myelotoxicity; Author-Supplied Keyword: Neutropenia; Author-Supplied Keyword: plating efficiency. (PE); Author-Supplied Keyword: Progenitor cells; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0887-2333(03)00012-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9854732&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Biswas, Robin
AU - Tabor, Edward
AU - Hsia, Chu Chieh
AU - Wright, David J.
AU - Laycock, Megan E.
AU - Fiebig, Eberhard W.
AU - Peddada, Lorraine
AU - Smith, Richard
AU - Schreiber, George B.
AU - Epstein, Jay S.
AU - Nemo, George J.
AU - Busch, Michael P.
T1 - Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection.
JO - Transfusion
JF - Transfusion
Y1 - 2003/06//
VL - 43
IS - 6
M3 - Article
SP - 788
EP - 798
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: A study was designed to estimate relative analytic sensitivity and window-period (WP) closure and to project incremental yield of newer HBsAg tests, pooled-sample NAT, and single-sample NAT, compared to currently licensed HBsAg tests. STUDY DESIGN AND METHODS: HBV DNA and HBsAg test results for 23 HBV seroconversion (SC) panels were first analyzed to construct a model of primary HBV viremia. One-hundred representative samples were then selected from 10 panels and coded with 28 analytical controls. All 128 samples were tested by seven HBsAg tests and by four pooled-sample and three single-sample NAT assay formats. Results were analyzed to obtain differential times to HBV detection and combined with HBV incidence rates to project comparative yields. RESULTS: HBV doubling time during the ramp-up phase was estimated at 2.56 days. HBsAg concentrations at cutoff for new tests ranged from 0.07 to 0.12 ng per mL, compared with 0.13 to 0.62 ng per mL for licensed tests. Estimated viral load at cutoff ranged from 102 to 267 IU per mL for new tests and from 363 to 1069 IU per mL for licensed tests. HBsAg tests detected 31 to 63 percent of early ramp-up phase samples in the 100-member seroconversion panel study, while pooled-sample NAT detected 55 to 71 percent and single-sample NAT, 82 to 99 percent. Compared with currently licensed HBsAg assays, newer HBsAg assays would reduce the WP by 2 to 9 days; pooled-sample NAT would reduce the WP by 9 to 11 days; and single-sample NAT would reduce the WP by 25 to 36 days. CONCLUSION: Newer HBsAg tests would be expected to detect an additional 15 to 21 infected units per 107 donations, compared to licensed HBsAg tests. Sensitivity, WP closure, and yield projections for newer HBsAg assays and pooled-sample NAT are comparable. Single-sample NAT would increase yield by 13 to 15 units per 107 donations over pooled-sample NAT and newer HBsAg assays and by 35 to 50 units per 107 donations over currently licensed HBsAg assays. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B virus
KW - NUCLEIC acids
N1 - Accession Number: 9989911; Biswas, Robin 1,2,3,4,5 Tabor, Edward 1,2,3,4,5 Hsia, Chu Chieh 1,2,3,4,5 Wright, David J. 1,2,3,4,5 Laycock, Megan E. 1,2,3,4,5 Fiebig, Eberhard W. 1,2,3,4,5 Peddada, Lorraine 1,2,3,4,5 Smith, Richard 1,2,3,4,5 Schreiber, George B. 1,2,3,4,5 Epstein, Jay S. 1,2,3,4,5 Nemo, George J. 1,2,3,4,5 Busch, Michael P. 1,2,3,4,5; Affiliation: 1: From the Food and Drug Administration, Center for Biologics Evaluation and Research and Westat, Inc., Rockville, Maryland; 2: Blood Centers of the Pacific, the University of California at San Francisco, and the San Francisco General Hospital, San Francisco, California; 3: Alpha Therapeutic Corporation and the National Genetics Institute, Los Angeles, California; 4: National Heart, Lung and Blood Institute, Bethesda, Maryland; 5: Blood Systems, Inc., Scottsdale, Arizona.; Source Info: Jun2003, Vol. 43 Issue 6, p788; Subject Term: HEPATITIS B virus; Subject Term: NUCLEIC acids; Number of Pages: 11p; Illustrations: 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1046/j.1537-2995.2003.00424.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9989911&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106727477
T1 - Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection.
AU - Biswas R
AU - Tabor E
AU - Hsia CC
AU - Wright DJ
AU - Laycock ME
AU - Fiebig EW
AU - Peddada L
AU - Smith R
AU - Schreiber GB
AU - Epstein JS
AU - Nemo GJ
AU - Busch MP
Y1 - 2003/06//
N1 - Accession Number: 106727477. Language: English. Entry Date: 20040423. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by the FDA and the National Heart, Lung, and Blood Institute's Retrovirus Epidemiology Donor Study (REDS), under the auspices of the REDS NAT Study Group. NLM UID: 0417360.
KW - Hepatitis B -- Diagnosis
KW - Nucleic Acid Amplification Techniques
KW - Sensitivity and Specificity
KW - Viral Load
KW - Antigens, Viral -- Blood
KW - Comparative Studies
KW - Chi Square Test
KW - Funding Source
KW - Human
SP - 788
EP - 798
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 43
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Food and Drug Administration Center for Biologics Evaluation and Research, Rockville, Maryland
U2 - PMID: 12757531.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106727477&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2003-05254-003
AN - 2003-05254-003
AU - DiGirolamo, Ann M.
AU - Grummer-Strawn, Laurence M.
AU - Fein, Sara B.
T1 - Do Perceived Attitudes, of Physicians and Hospital Staff Affect Breastfeeding Decisions?
JF - Birth: Issues in Perinatal Care
JO - Birth: Issues in Perinatal Care
JA - Birth
Y1 - 2003/06//
VL - 30
IS - 2
SP - 94
EP - 100
CY - United Kingdom
PB - Blackwell Publishing
SN - 0730-7659
SN - 1523-536X
AD - Grummer-Strawn, Laurence M., Centers for Disease Control and Prevention, Mailstop K-25, 4770 Buford Hwy., N.E., Atlanta, GA, US, 30341-3717
N1 - Accession Number: 2003-05254-003. PMID: 12752166 Partial author list: First Author & Affiliation: DiGirolamo, Ann M.; Department of International Health, Rollins School of Public Health of Emory University, Atlanta, GA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040531. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Caregivers; Health Personnel Attitudes; Medical Personnel; Mothers. Minor Descriptor: Demographic Characteristics; Hospitals; Physicians; Psychosocial Factors. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2003.
AB - Assesses the impact on breastfeeding of the perceived attitudes of health care providers about infant feeding. A longitudinal mail survey (1993-1994) was administered to 1620 women prenatally through 12 months postpartum, the current study focused on the prenatal and neonatal periods (66% response rate). The outcome variable was failure to breastfeed beyond 6 weeks. Predictor variables were the mother's perceptions of her prenatal physician's and hospital staff's attitudes on infant feeding. Analysis controlled for mother's prenatal breastfeeding intentions, father's feeding preference, and demographic and psychosocial variables. Forty-one percent of the mothers were not breastfeeding at 6 weeks postpartum. Substantial percentages of mothers reported that physicians and hospital staff expressed a preference for breastfeeding, or expressed no preference, whereas few favored formula feeding. 'No preference' by physicians did not significantly influence breastfeeding outcome in these analyses. Further analyses indicated that the effects of perceived hospital staff attitudes were only present for mothers who intended prenatally to breastfeed for 2 months or less. Many women did not report receiving positive breastfeeding messages from their health caregivers and hospital staff. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perceived attitudes
KW - hospital staff
KW - physicians
KW - breastfeeding
KW - health care providers
KW - infant feeding
KW - demographic variables
KW - psychosocial variables
KW - 2003
KW - Breast Feeding
KW - Caregivers
KW - Health Personnel Attitudes
KW - Medical Personnel
KW - Mothers
KW - Demographic Characteristics
KW - Hospitals
KW - Physicians
KW - Psychosocial Factors
KW - 2003
DO - 10.1046/j.1523-536X.2003.00227.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05254-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05743-001
AN - 2003-05743-001
AU - DeMartino, Robert E.
AU - Crosby, Alexander E.
AU - EchoHawk, Marlene
AU - Litts, David A.
AU - Pearson, Jane
AU - Reed, Gerald A.
AU - West, Margaret
T1 - A call to collaboration: The federal commitment to suicide prevention.
JF - Suicide and Life-Threatening Behavior
JO - Suicide and Life-Threatening Behavior
JA - Suicide Life Threat Behav
Y1 - 2003///Sum 2003
VL - 33
IS - 2
SP - 101
EP - 110
CY - US
PB - Guilford Publications
SN - 0363-0234
SN - 1943-278X
AD - DeMartino, Robert E., Substance Abuse & Mental Health Services Administration, U.S. Public Health Service, 5600 Fishers Lane, Room 17C-26, Rockville, MD, US, 20857
N1 - Accession Number: 2003-05743-001. PMID: 12882412 Other Journal Title: Life-Threatening Behavior; Suicide. Partial author list: First Author & Affiliation: DeMartino, Robert E.; US Dept of Health & Human Services, Substance Abuse & Mental Health Services Administration, Rockville, MD, US. Other Publishers: Behavioral Publications; Human Sciences Press, Inc.; Wiley-Blackwell Publishing Ltd. Release Date: 20030804. Correction Date: 20130610. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Government; Integrated Services; Suicide Prevention. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 10. Issue Publication Date: Sum 2003.
AB - The federal government, largely through the U.S. Department of Health and Human Services (HHS), sponsors an array of science-based suicide prevention initiatives. This article details the prevention-related agendas and collaborative efforts of five operating divisions within the Department of Health and Human Services: the Substance Abuse and Mental Health Services Administration, National Institutes of Health, Centers for Disease Control and Prevention, Indian Health Service, and Health Resources and Services Administration. The article highlights HHS's activities and their link to the National Strategy for Suicide Prevention, the plan which will guide the nation's suicide prevention efforts for the next decade. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention
KW - federal government
KW - collaborative efforts
KW - 2003
KW - Government
KW - Integrated Services
KW - Suicide Prevention
KW - 2003
DO - 10.1521/suli.33.2.101.22772
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05743-001&site=ehost-live&scope=site
UR - rdemarti@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-09498-006
AN - 2003-09498-006
AU - Schmued, Larry C.
T1 - Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2003/06//
VL - 974
IS - 1-2
SP - 127
EP - 133
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Schmued, Larry C., Department of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US, 72079
N1 - Accession Number: 2003-09498-006. PMID: 12742630 Partial author list: First Author & Affiliation: Schmued, Larry C.; Department of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20040823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain Damage; Forebrain; Methylenedioxymethamphetamine; Neurons; Serotonin. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2003.
AB - Methylenedioxymethamphetamine (MDMA, Ecstasy) is a powerful releaser of serotonin. Increasing recreational use of this stimulant and hallucinogenic drug has raised concerns about its potential to produce brain damage. The vast majority of previous research studies have focused on the compound's ability to deplete serotonin (5-hydroxytryptamine, 5-HT) from axon terminals. Despite extensive research on this '5-HT terminal neurotoxicity', a much less studied aspect of MDMA toxicity involves its ability to actually kill nerve cells. Only two prior studies mention the existence of MDMA-induced neuronal degeneration, as reflected by a limited number of argyrophylic neurons within the somatosensory cortex, following very high doses of MDMA. The development of Fluoro-Jade B as a simple and reliable marker of neuronal degeneration has allowed us to conduct the first comprehensive localization of MDMA induced neuronal degeneration throughout the entire rat forebrain. In addition to the previously reported neuronal degeneration within parietal cortex, degenerating neurons were also observed in the insular/perirhinal cortex, the ventromedial/ventrolateral thalamus, and the tenia tecta. The extent of neuronal degeneration observed generally correlated with the degree of hypothermia achieved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methylenedioxymethamphetamine
KW - serotonin
KW - brain damage
KW - nerve cells
KW - neuronal degeneration
KW - rat forebrain
KW - 2003
KW - Brain Damage
KW - Forebrain
KW - Methylenedioxymethamphetamine
KW - Neurons
KW - Serotonin
KW - Rats
KW - 2003
DO - 10.1016/S0006-8993(03)02563-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-09498-006&site=ehost-live&scope=site
UR - lschmued@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-08702-009
AN - 2003-08702-009
AU - Reijneveld, S. A.
AU - Vogels, A. G. C.
AU - Brugman, E.
AU - van Ede, J.
AU - Verhulst, F. C.
AU - Verloove-Vanhorick, S. P.
T1 - Early detection of psychosocial problems in adolescents: How useful is the Dutch short indicative questionnaire (KIVPA)?
JF - European Journal of Public Health
JO - European Journal of Public Health
JA - Eur J Public Health
Y1 - 2003/06//
VL - 13
IS - 2
SP - 152
EP - 158
CY - United Kingdom
PB - Oxford University Press
SN - 1101-1262
SN - 1464-360X
AD - Reijneveld, S. A., TNO Prevention and Health, P.O. Box 2215, 2301 CE, Leiden, Netherlands
N1 - Accession Number: 2003-08702-009. Partial author list: First Author & Affiliation: Reijneveld, S. A.; TNO Prevention and Health, Leiden, Netherlands. Release Date: 20040726. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Psychometrics; Psychosocial Development; Questionnaires. Classification: Tests & Testing (2220); Psychosocial & Personality Development (2840). Population: Human (10). Location: Netherlands. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2003.
AB - The aim of this study is to assess the psychometric qualities of such a questionnaire, the Short Indicative Questionnaire for Psychosocial problems among Adolescents (KIVPA,) and to determine whether it is suitable for and adds to the early detection of psychosocial problems among adolescents. In the method, data came from a national sample of 1,440 Dutch adolescents, using the KIVPA, the Child Behavior Checklist (CBCL), and the Youth Self-Report (YSR). Of these, 1,248 provided data on all questionnaires (77.8%). The scale structure of the KIVPA was assessed; its sensitivity and specificity using CBCL, YSR and referral for psychosocial problems as criteria; and its contribution to detecting CBCL and YSR problems. Results showed that the KIVPA is mostly uni-dimensional but the variance explained by its main factor is relatively low. The total KIVPA score discriminates between adolescents with and without problems on the three criteria. Using a clinical YSR total problem score as criterion, sensitivity and specificity are 0.82 and 0.85, respectively, at the proposed cut-off. It was concluded that the KIVPA has added value in the early detection of internalizing psychosocial problems, but is not sufficiently efficient. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial problems
KW - psychometric qualities
KW - Short Indicative Questionnaire for Psychosocial problems among Adolescents
KW - 2003
KW - Psychometrics
KW - Psychosocial Development
KW - Questionnaires
KW - 2003
DO - 10.1093/eurpub/13.2.152
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-08702-009&site=ehost-live&scope=site
UR - SA.Reijneveld@pg.tno.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99608-005
AN - 2003-99608-005
AU - Mark, Tami L.
AU - Dilonardo, Joan D.
AU - Chalk, Mady
AU - Coffey, Rosanna M.
T1 - Factors associated with the receipt of treatment following detoxification.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2003/06//
VL - 24
IS - 4
SP - 299
EP - 304
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Mark, Tami L., Medstat, 4301 Connecticut Avenue, NW, Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2003-99608-005. PMID: 12867203 Partial author list: First Author & Affiliation: Mark, Tami L.; Medstat, Washington, DC, US. Release Date: 20030825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: American Public Health Association Meetings, Nov, 2002, US. Conference Note: Parts of this paper were presented as a poster at the aforementioned meetings. Major Descriptor: Detoxification; Drug Abuse; Drug Rehabilitation; Managed Care. Minor Descriptor: Outpatient Treatment; Rehabilitation. Classification: Drug & Alcohol Rehabilitation (3383); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2003.
AB - This paper examines the determinants of whether an individual received continuing treatment/rehabilitation services 30 days after receiving inpatient substance abuse detoxification. Data came from 1997-1999 employer health insurance claims. Only 49.4% of detoxification episodes were followed by continuing mental health or substance abuse treatment within 30 days after discharge. Some of the factors positively associated with receiving continuing treatment after receiving detoxification included: female gender, being in a behavioral health carve-out plan, and lower cost-sharing requirements for an outpatient substance abuse visit. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment
KW - detoxification
KW - managed care
KW - rehabilitation
KW - inpatient substance abuse
KW - 2003
KW - Detoxification
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Managed Care
KW - Outpatient Treatment
KW - Rehabilitation
KW - 2003
DO - 10.1016/S0740-5472(03)00039-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99608-005&site=ehost-live&scope=site
UR - Tami.Mark@Medstat.Com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07650-023
AN - 2006-07650-023
AU - O'Neill, Joseph
AU - Marconi, Katherine
T1 - Underserved Populations, Resource-Poor Settings, and HIV: Innovative Palliative Care Projects.
JF - Journal of Palliative Medicine
JO - Journal of Palliative Medicine
JA - J Palliat Med
Y1 - 2003/06//
VL - 6
IS - 3
SP - 457
EP - 459
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1096-6218
SN - 1557-7740
AD - Marconi, Katherine, HIV/AIDS Bureau, HRSA Office of Science & Epidemiology, 5600 Fishers Lane, Room 7-90, Rockville, MD, US, 20857
N1 - Accession Number: 2006-07650-023. PMID: 14509495 Partial author list: First Author & Affiliation: O'Neill, Joseph; HIV/AIDS Bureau, Health Resources and Services Administration (HRSA), Rockville, MD, US. Release Date: 20061218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; HIV; Life Experiences; Pain; Palliative Care. Minor Descriptor: Developing Countries. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jun, 2003.
AB - During the early 1600s, the Italian painter Artemisia Gentileschi produced many paintings of suffering and death, drawing on images from the Old Testament. Her paintings convey, in rich colors and many shadings, pain, beauty, suffering but also comfort and hope-often within the same scene. Her paintings visually depict messages that the writers of this issue of Innovations strive to convey about the complex process of living with and dying from human immunodeficiency syndrome (HIV). As the authors illustrate, caring for individuals with HIV, whether here in the United States or in developing countries, forces us to delve into our concepts of living and dying. The writers featured here may come from a variety of settings and backgrounds, but the stories that they address center on these common themes. Despite the different populations and care settings addressed in this issue, the authors found that flexibility in therapies, integration of curative and palliative care, and a wide variety of support services are necessary. The conditions that led to care challenges stemmed not just from HIV but also from many other life experiences that patients faced. Such conditions required a flexible approach to delivering services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - uderserved populations
KW - palliative care
KW - sufferings
KW - death and dying
KW - pain
KW - human immunodeficiency syndrome
KW - life experiences
KW - 2003
KW - Death and Dying
KW - HIV
KW - Life Experiences
KW - Pain
KW - Palliative Care
KW - Developing Countries
KW - 2003
DO - 10.1089/109662103322144835
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07650-023&site=ehost-live&scope=site
UR - kmarconi@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99149-013
AN - 2003-99149-013
AU - London, Andrew S.
AU - Foote-Ardah, Carrie E.
AU - Fleishman, John A.
AU - Shapiro, Martin F.
T1 - Use of alternative therapists among people in care for HIV in the United States.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/06//
VL - 93
IS - 6
SP - 980
EP - 987
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - London, Andrew S., Center for Policy Research, Syracuse University, 426 Eggers Hall, Syracuse, NY, US, 13244-1020
N1 - Accession Number: 2003-99149-013. PMID: 12773365 Partial author list: First Author & Affiliation: London, Andrew S.; Department of Sociology and Center for Policy Research, Syracuse University, Syracuse, NY, US. Release Date: 20031117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alternative Medicine; HIV; Patients; Therapists; Treatment. Minor Descriptor: Demographic Characteristics; Health Care Utilization. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2003.
AB - This study examined the influence of sociodemographic, clinical, and attitudinal variables on the use of alternative therapists by people in care for HIV. Bivariate and multivariate analyses of baseline data from the nationally representative HIV Cost and Services Utilization Study were conducted. Overall, 15.4% had used an alternative therapist, and among users, 53.9% had fewer than 5 visits in the past 6 months. Use was higher for people who were gay/lesbian, had incomes above $40000, lived in the Northeast and West, were depressed, and wanted more information about and more decisionmaking involvement in their care. Among users, number of visits was associated with age, education, sexual orientation, insurance status, and CD4 count. Among people receiving medical care for HIV, use of complementary care provided by alternative therapists is associated with several sociodemographic, clinical, and attitudinal variables. Evaluation of the coordination of provider-based alternative and standard medical care is needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attitudinal variables
KW - medical care
KW - alternative therapist
KW - sociodemographic variables
KW - clinical variables
KW - HIV care
KW - 2003
KW - Alternative Medicine
KW - HIV
KW - Patients
KW - Therapists
KW - Treatment
KW - Demographic Characteristics
KW - Health Care Utilization
KW - 2003
DO - 10.2105/AJPH.93.6.980
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99149-013&site=ehost-live&scope=site
UR - aslondon@maxwell.syr.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05764-002
AN - 2003-05764-002
AU - Hoffman, Alexander F.
AU - Oz, Murat
AU - Caulder, Tara
AU - Lupica, Carl R.
T1 - Functional Tolerance and Blockade of Long-Term Depression at Synapses in the Nucleus Accumbens after Chronic Cannabinoid Exposure.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2003/06//
VL - 23
IS - 12
SP - 4815
EP - 4820
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Lupica, Carl R., Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD, US, 21224
N1 - Accession Number: 2003-05764-002. PMID: 12832502 Partial author list: First Author & Affiliation: Hoffman, Alexander F.; Cellular Neurobiology Branch, Section on Cellular Neurophysiology, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, MD, US. Release Date: 20040628. Correction Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cannabinoids; Marijuana; Nucleus Accumbens; Spreading Depression; Synapses. Minor Descriptor: Brain; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2003.
AB - The rewarding properties of the psychoactive constituents of marijuana, termed 'cannabinoids,' may reflect actions on synaptic transmission in the nucleus accumbens. Excitatory and inhibitory synapses are acutely inhibited by cannabinoids in the NAc, and endogenous cannabinoids play a critical role in the expression of long-term depression of excitatory cortical afferents in this structure. Electrophysiological recordings in rat brain slices containing the NAc were performed after chronic exposure to vehicle solution. Extracellular glutamatergic postsynaptic potentials and whole-cell GABAergic IPSCs were concentration-dependently inhibited by WIN55,212-2 in slices from naive or vehicle-treated animals. Endocannabinoid-mediated LTD was initiated via electrical stimulation of glutamatergic afferents to the NAc and was completely blocked by the cannabinoid receptor antagonist SR141716A [N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide] in vehicle-treated animals. These data demonstrate that long-term exposure to the active ingredient of marijuana blocks synaptic plasticity in the NAc and reduces the sensitivity of GABAergic and glutamatergic synapses to both cannabinoids and opioids. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - functional tolerance
KW - depression blockade
KW - synapses
KW - nucleus accumbens
KW - chronic cannabinoid exposure
KW - marijuana
KW - rat brain slices
KW - 2003
KW - Cannabinoids
KW - Marijuana
KW - Nucleus Accumbens
KW - Spreading Depression
KW - Synapses
KW - Brain
KW - Rats
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05764-002&site=ehost-live&scope=site
UR - clupica@intra.nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Prival, Michael J.
T1 - The unusual effect of pKM101 on the mutagenicity of acetaldehyde oxime in Salmonella typhimurium
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2003/06/06/
VL - 537
IS - 2
M3 - Article
SP - 201
SN - 13835718
AB - Acetaldehyde oxime was found to induce more revertants in Salmonella typhimurium strain TA1535 than in TA100 in the absence of S9 metabolic activation. TA100 was originally constructed from TA1535 by the addition of the plasmid pKM101, carrying mucAB which generally enhances sensitivity to the mutagenic effects of chemicals. The role of pKM101 in lowering the sensitivity to acetaldehyde oxime was explored by: (1) increasing the incubation time of the selective agar plates from 2 to 3 days; (2) using a new strain, isogenic to TA100, constructed by introducing pKM101 into the TA1535 isolate used in these experiments; (3) by testing a strain constructed by inserting into TA1535 a plasmid carrying mucAB but otherwise unrelated to pKM101. Each of these alterations increased the number of revertants per plate in the presence of acetaldehyde oxime, indicating that the apparent nonmutagenicity of this chemical in TA100 is due to multiple factors. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acetaldehyde
KW - Mutagenesis
KW - Acetaldoxime
KW - Acetaldehyde oxime
KW - mucAB
KW - Salmonella typhimurium
N1 - Accession Number: 9908605; Prival, Michael J. 1; Email Address: mprival@aol.com; Affiliations: 1: Division of In Vitro and Biochemical Toxicology (HFS-25), U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Issue Info: Jun2003, Vol. 537 Issue 2, p201; Thesaurus Term: Acetaldehyde; Subject Term: Mutagenesis; Subject Term: Acetaldoxime; Author-Supplied Keyword: Acetaldehyde oxime; Author-Supplied Keyword: mucAB; Author-Supplied Keyword: Salmonella typhimurium; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S1383-5718(03)00087-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9908605&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, S.M.
AU - Akerman, G.S.
AU - Warbritton, A.R.
AU - Patton, R.E.
AU - Doerge, D.R.
AU - Ding, Xuhong
AU - Chen, J.J.
T1 - Effect of dietary genistein on cell replication indices in C57BL6 mice
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2003/06/10/
VL - 195
IS - 2
M3 - Article
SP - 139
SN - 03043835
AB - The phytoestrogen and isoflavone, genistein, inhibited the activity of the DNA synthesis-related enzyme, topoisomerase-II (topo-II), altered cell-cycle traverse and produced cell death in cell culture models. In order to examine the potential effects of genistein on cell replication and cell death in an animal model, 8-week-old C57BL6 mice were fed either a control diet or one containing one of five doses (100–2000 ppm) of genistein for 28 days. At the end of the feeding period, both male and female mice were sacrificed and the serum isoflavone and aglycone levels determined by liquid chromatography with electrospray tandem mass spectrometry (LC–ES/MS/MS). Immunohistochemistry was utilized to measure the cell replication and cell death rates in the small intestine. Total isoflavone concentration increased from below the limits of detection (0.001 μM) in control animals to 0.28 μM in male and 0.54 μM in female mice fed the 2000 ppm diet. A decrease in the percentage of cells in G0 and an increase in the percentage of cells in S-phase, consistent with topo-II-induced S-phase arrest, was found in the duodenum and jejunum of the small intestine. Thus, genistein appears to accumulate to a sufficient level to affect topo-II activity in the small intestine. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYTOESTROGENS
KW - APOPTOSIS
KW - C57BL6
KW - Cell replication
KW - Feeding trial
KW - Genistein
N1 - Accession Number: 9857572; Morris, S.M. 1; Email Address: smorris@nctr.fda.gov Akerman, G.S. 1 Warbritton, A.R. 2 Patton, R.E. 2 Doerge, D.R. 3 Ding, Xuhong 4 Chen, J.J. 5; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-120/DGRT/NCTR, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Charles River Laboratories, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 4: Northrup-Grumman IT, 3900 NCTR Road, Jefferson, AR 72079, USA 5: Division of Biometry and Risk Assessment, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jun2003, Vol. 195 Issue 2, p139; Subject Term: PHYTOESTROGENS; Subject Term: APOPTOSIS; Author-Supplied Keyword: C57BL6; Author-Supplied Keyword: Cell replication; Author-Supplied Keyword: Feeding trial; Author-Supplied Keyword: Genistein; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0304-3835(03)00155-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9857572&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106856701
T1 - Boosting performance measure for measure.
AU - Stryer D
AU - Clancy C
Y1 - 2003/06/14/
N1 - Accession Number: 106856701. Language: English. Entry Date: 20030808. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866.
KW - Accountability
KW - Quality Assurance
KW - Quality of Health Care
KW - Access to Information
KW - Consumer Advocacy
KW - Consumer Attitudes
KW - Quality Improvement
SP - 1278
EP - 1278
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
JA - BMJ
VL - 326
IS - 7402
PB - BMJ Publishing Group
SN - 0959-8146
AD - Acting Director, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD 20850; dstryer@ahrq.gov
U2 - PMID: 12805128.
DO - 10.1136/bmj.326.7402.1278
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106856701&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goldin, Lynn R.
AU - Ishibe, Naoko
AU - Sgambati, Maria
AU - Marti, Gerald E.
AU - Fontaine, Laura
AU - Lee, Maxwell P.
AU - Kelley, Jenny M.
AU - Scherpbier, Titia
AU - Buetow, Kenneth H.
AU - Caporaso, Neil E.
T1 - A genome scan of 18 families with chronic lymphocytic leukaemia.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2003/06/15/
VL - 121
IS - 6
M3 - Article
SP - 866
EP - 873
PB - Wiley-Blackwell
SN - 00071048
AB - Summary. Chronic lymphocytic leukaemia (CLL) accounts for about 30% of all leukaemias and is most prevalent in older individuals. Significant familial aggregation has been demonstrated but the mode of inheritance is unknown. Recurrent cytogenetic abnormalities are frequently found in CLL tumour cells but no susceptibility genes have been confirmed. We have collected clinical data and biospecimens on families ascertained for having at least two living patients with CLL. The current study included DNA samples from 94 individuals (38 affected patients) in 18 families. We have carried out a genome scan using the ABI 28-panel medium density linkage mapping set (average spacing of 10 cM and average heterozygosity of 80%). Genotypes for 359 markers were scored. Multipoint limit of detection (lod) scores were calculated, assuming both dominant and recessive inheritance and allowing for increased penetrance with age and genetic heterogeneity. Non-parametric linkage scores were also calculated. Lod scores of 1·0 or greater were found on regions of chromosomes 1, 3, 6, 12, 13 and 17, but none of these loci achieved statistical significance. Four of these six regions (6q, 13q, 12 and 17p) coincide with areas where cytogenetic abnormalities are frequently observed in CLL tumour cells and are, therefore, strong candidate regions for containing germ line changes. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - OLDER people -- Diseases
KW - HUMAN cytogenetics
KW - ANTIBODY diversity
KW - GENOMICS
KW - candidate genes
KW - chronic lymphocytic leukaemia
KW - family studies
KW - genetics
KW - linkage mapping
N1 - Accession Number: 10130986; Goldin, Lynn R. 1 Ishibe, Naoko 1 Sgambati, Maria 1 Marti, Gerald E. 2 Fontaine, Laura 1 Lee, Maxwell P. 3 Kelley, Jenny M. 3 Scherpbier, Titia 3 Buetow, Kenneth H. 3 Caporaso, Neil E. 1; Affiliation: 1: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 2: Flow and Image Cytometry Section, Division of Cell and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, and 3: Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA; Source Info: Jun2003, Vol. 121 Issue 6, p866; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: OLDER people -- Diseases; Subject Term: HUMAN cytogenetics; Subject Term: ANTIBODY diversity; Subject Term: GENOMICS; Author-Supplied Keyword: candidate genes; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: family studies; Author-Supplied Keyword: genetics; Author-Supplied Keyword: linkage mapping; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1365-2141.2003.04372.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10130986&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turesky, Robert J.
AU - Richoz, Janique
AU - Constable, Anne
AU - Curtis, Kellie D.
AU - Dingley, Karen H.
AU - Turteltaub, Kenneth W.
T1 - The effects of coffee on enzymes involved in metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2003/06/15/
VL - 145
IS - 3
M3 - Article
SP - 251
SN - 00092797
AB - The effects of coffee on the metabolism and genotoxicity of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were investigated. Coffee diminished the bacterial mutagenicity of PhIP in the Ames reversion assay through inhibition of cytochrome P450 1A2 (CYP1A2), a key enzyme involved in the metabolic activation of PhIP. When given as part of the diet (0, 1 or 5% w/w) to male Fischer-344 rats for 2 weeks, coffee affected the expression of hepatic enzymes involved in PhIP metabolism. Coffee increased the expression of CYP1A2 by 16-fold in the 5% coffee-treated group, and approximately half of this inductive effect was attributed to caffeine. Coffee also increased the expression of enzymes involved in the detoxication of PhIP. A 2-fold increase in expression of glutathione S-transferase alpha was observed, UDP-glucuronosyl transferase (UGTs) activities of p-nitrophenol increased 2-fold, while N2-and N3-glucuronidation of the genotoxic metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (HONH-PhIP) increased by 1.3-fold in the 5% coffee-treated over the control group. The amount of PhIP (0.75 mg/kg, 24 h) eliminated in urine as the N2-and N3-glucuronide conjugates of HONH-PhIP increased by 1.8- and 2.5-fold, respectively, in the 5% coffee-treated group over control rats, suggesting either increased rates of N-oxidation of PhIP or N-glucuronidation of HONH-PhIP. Despite the strong induction of CYP1A2, there was no increase in PhIP-DNA adduct formation in colon and pancreas while liver adducts decreased by 50% over control animals. These data suggest that the effect of coffee on inhibition of PhIP N-oxidation and ensuing DNA damage is more important in vivo than its effect on induction of PhIP N-hydroxylation. [Copyright &y& Elsevier]
AB - Copyright of Chemico-Biological Interactions is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HETEROCYCLIC compounds
KW - CAFFEINE
KW - Caffeine
KW - Chemoprotection
KW - Coffee
KW - Heterocyclic aromatic amines
KW - Metabolism
N1 - Accession Number: 9656462; Turesky, Robert J. 1,2; Email Address: rturesky@nctr.fda.gov Richoz, Janique 2 Constable, Anne 2 Curtis, Kellie D. 3 Dingley, Karen H. 3 Turteltaub, Kenneth W. 3; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland 3: Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA; Source Info: Jun2003, Vol. 145 Issue 3, p251; Subject Term: HETEROCYCLIC compounds; Subject Term: CAFFEINE; Author-Supplied Keyword: Caffeine; Author-Supplied Keyword: Chemoprotection; Author-Supplied Keyword: Coffee; Author-Supplied Keyword: Heterocyclic aromatic amines; Author-Supplied Keyword: Metabolism; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/S0009-2797(03)00022-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9656462&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Chang, Cheng-Nan
AU - Chu, Chia-Chium
AU - Wu, Yuh-Shen
AU - Pi-Cheng Fu, Peter
AU - Chang, Shyh-Chyi
AU - Yang, I-Lin
T1 - Fine (PM2.5), coarse (PM2.5–10), and metallic elements of suspended particulates for incense burning at Tzu Yun Yen temple in central Taiwan
JO - Chemosphere
JF - Chemosphere
Y1 - 2003/06/15/
VL - 51
IS - 9
M3 - Article
SP - 983
SN - 00456535
AB - Ambient suspended particulate concentrations were measured at Tzu Yun Yen temple (120°, 34′, 10″ E; 24°, 16′, 12″ N) in this study. This is representative of incense burning and semi-open sampling sites. The Universal-sampler collected fine and coarse particle material was used to measure suspended particulate concentrations, and sampling periods were from 16/08/2001 to 2/1/2002 at Tzu Yun Yen temple. In addition, metallic element concentrations, compositions of PM2.5 and PM2.5–10 for incense burning at Tzu Yun Yen temple were also analyzed in this study. The PM2.5/PM10 ratios ranged between 31% and 87% and averaged 70 ± 11% during incense the burning period, respectively. The median metallic element concentration order for these elements is Fe > Zn > Cr > Cd > Pb > Mn > Ni > Cu in fine particles (PM2.5) at the Tzu Yun Yen temple sampling site. The median metallic element concentration order for these elements is Fe > Zn > Cr > Pb > Cd > Ni > Mn > Cu in coarse particle (PM2.5–10) at the Tzu Yun Yen temple sampling site. Fine particulates (PM2.5) are the main portion of PM10 at Tzu Yun Yen temple in this study. From the point of view of PM10, these data reflect that the elements Fe, Zn, and Cr were the major elements distributed at Tzu Yun Yen temple in this study. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INCENSE
KW - TEMPLES
KW - IRON
KW - ZINC
KW - CHROMIUM
KW - Coarse particle
KW - Fine particle
KW - Incense
KW - Metallic elements
KW - Temple
N1 - Accession Number: 9570416; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw Chang, Cheng-Nan 2 Chu, Chia-Chium 3 Wu, Yuh-Shen 1 Pi-Cheng Fu, Peter 4 Chang, Shyh-Chyi 2 Yang, I-Lin 2; Affiliation: 1: Air Toxic and Environmental Analysis Laboratory, Department of Environmental Engineering, Hungkuang Institute of Technology, Hungkuang University, Sha-Lu, Taichung 433, Taiwan 2: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan 3: The Chief of Intensive Care Unit, Department of Internal Medicine, Intensive Care Unit, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan 4: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Jun2003, Vol. 51 Issue 9, p983; Subject Term: INCENSE; Subject Term: TEMPLES; Subject Term: IRON; Subject Term: ZINC; Subject Term: CHROMIUM; Author-Supplied Keyword: Coarse particle; Author-Supplied Keyword: Fine particle; Author-Supplied Keyword: Incense; Author-Supplied Keyword: Metallic elements; Author-Supplied Keyword: Temple; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 813110 Religious Organizations; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0045-6535(03)00124-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9570416&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aidoo, Anane
AU - Mittelstaedt, Roberta A.
AU - Bishop, Michelle E.
AU - Lyn-Cook, Lascelles E.
AU - Chen, Yi-Ju
AU - Duffy, Peter
AU - Heflich, Robert H.
T1 - Effect of caloric restriction on Hprt lymphocyte mutation in aging rats
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/06/19/
VL - 527
IS - 1/2
M3 - Article
SP - 57
SN - 00275107
AB - Caloric restriction (CR) reduces tumor incidence and retards aging in laboratory animals, including non-human primates. Because of the relationships among mutation, disease susceptibility, and aging, we investigated whether or not CR affects the accumulation of somatic cell mutations in aging animals. Starting at approximately 2 months of age, male CD rats (Harlan Sprague–Dawley-derived) were placed on different levels of dietary intake: ad libitum (AL) feeding, and 90% (10% CR), 75% (25% CR) and 60% (40% CR) of the total calories consumed by AL animals. At 3, 6, 12, and 24 months after the beginning of CR, Hprt mutant frequencies (MFs) were determined. The MFs measured in spleen lymphocytes from AL and CR rats sacrificed at 3 months of dietary restriction were similar for all dietary groups. However, the MFs at 6, 12, and 24 months of CR were significantly higher in AL-fed rats compared with animals on 40% CR: (4.5±0.4)×10−6 versus (3.3±0.3)×10−6 (P=0.032 ) in 6 months CR rats; (10.3±2.3)×10−6 versus (7.3±1.2)×10−6 in 12 months CR rats (P=0.04 ), and (18.3±3.2)×10−6 versus (7.8±1.0)×10−6 (P=0.001 ) in 24 months CR rats. In addition, rats receiving 25% CR for 24 months had a MF, (10.7±2.0)×10−6 , between the 40% CR and AL rats. Multiplex PCR of the Hprt gene in mutant clones from 12 and 24 months 40% CR rats and the corresponding AL rats detected deletions in 42% of CR mutants and 19% of AL mutants. Because of the difference in Hprt MF in the two groups, the estimated MF associated with deletions in CR rats was similar to the deletion MF in AL rats. This observation implies that the lower MF in CR rats is due to a reduction in smaller Hprt mutations (i.e. base substitutions and frameshifts). The pattern of smaller Hprt mutations from AL rats suggests that many were produced by reactive oxygen species (ROS). The results indicate that CR reduces the accumulation of spontaneous somatic cell mutation in aging rats, especially those caused by base substitutions and frameshifts. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - AGING
KW - ad libitum
KW - Aging
KW - Caloric restriction
KW - Hprt mutation
KW - Reactive oxygen species
N1 - Accession Number: 9908262; Aidoo, Anane 1; Email Address: aaidoo@nctr.fda.gov Mittelstaedt, Roberta A. 1 Bishop, Michelle E. 1 Lyn-Cook, Lascelles E. 1 Chen, Yi-Ju 2 Duffy, Peter 1 Heflich, Robert H. 1; Affiliation: 1: U.S. FDA Jefferson Laboratories, Division of Genetic & Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: U.S. FDA Jefferson Laboratories, Division of Biometry & Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Jun2003, Vol. 527 Issue 1/2, p57; Subject Term: LOW-calorie diet; Subject Term: AGING; Author-Supplied Keyword: ad libitum; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Caloric restriction; Author-Supplied Keyword: Hprt mutation; Author-Supplied Keyword: Reactive oxygen species; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0027-5107(03)00072-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9908262&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brezna, Barbara
AU - Khan, Ashraf A.
AU - Cerniglia, Carl E.
T1 - Molecular characterization of dioxygenases from polycyclic aromatic hydrocarbon-degrading Mycobacterium spp.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2003/06/27/
VL - 223
IS - 2
M3 - Article
SP - 177
SN - 03781097
AB - Polycyclic aromatic hydrocarbon (PAH)-degrading genes nidA and nidB that encode the α and β subunits of the aromatic ring-hydroxylating dioxygenase have been cloned and sequenced from Mycobacterium vanbaalenii PYR-1 [Khan et al., Appl. Environ Microbiol. 67 (2001) 3577–3585]. In this study, the presence of nidA and nidB in 12 other Mycobacterium or Rhodococcus strains was investigated. Initially, all strains were screened for their ability to degrade PAHs by a spray plate method, and for the presence of the dioxygenase Rieske center region by polymerase chain reaction (PCR). Only Mycobacterium sp. PAH 2.135 (RJGII-135), M. flavescens PYR-GCK (ATCC 700033), M. gilvum BB1 (DSM 9487) and M. frederiksbergense FAn9T (DSM 44346), all previously known PAH degraders, were positive in both tests. From the three positive strains, complete open reading frames of the nidA and nidB genes were amplified by PCR, using primers designed according to the known nidA and nidB sequences from PYR-1, cloned in the pBAD/Thio-TOPO vector and sequenced. The sequences showed >98% identity with the M. vanbaalenii PYR-1 nidA and nidB genes. Southern DNA–DNA hybridization using nidA and nidB probes from PYR-1 revealed that there is more than one copy of nidA and nidB genes in the strains PYR-1, BB1, PYR-GCK and FAn9T. However, only one copy of each gene was observed in PAH2.135. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic compounds
KW - Hydroxylation
KW - Dioxygenase
KW - Diversity
KW - DNA sequence
KW - Mycobacterium
KW - Polycyclic aromatic hydrocarbon degradation
N1 - Accession Number: 10062441; Brezna, Barbara 1,2; Khan, Ashraf A. 1; Email Address: ashraf@nctr.fda.gov; Cerniglia, Carl E. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; 2: Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic; Issue Info: Jun2003, Vol. 223 Issue 2, p177; Thesaurus Term: Polycyclic aromatic compounds; Subject Term: Hydroxylation; Author-Supplied Keyword: Dioxygenase; Author-Supplied Keyword: Diversity; Author-Supplied Keyword: DNA sequence; Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: Polycyclic aromatic hydrocarbon degradation; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0378-1097(03)00328-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=10062441&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106687304
T1 - Alternative field methods for measuring hearing protector performance.
AU - Franks JR
AU - Murphy WJ
AU - Harris DA
AU - Johnson JL
AU - Shaw PB
Y1 - 2003/07//Jul/Aug2003
N1 - Accession Number: 106687304. Language: English. Entry Date: 20040102. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101146781.
KW - Ear Protective Devices -- Evaluation
KW - Field Studies -- Methods
KW - Noise -- Prevention and Control
KW - Adult
KW - Auditory Threshold
KW - Bone Conduction
KW - Descriptive Statistics
KW - Evaluation Research
KW - Female
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Linear Regression
KW - Male
KW - Product Evaluation
KW - Repeated Measures
KW - Students, College
KW - Human
SP - 501
EP - 509
JO - AIHA Journal
JF - AIHA Journal
JA - AIHA J
VL - 64
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In comparison with the mandatory noise reduction rating (NRR) testing of every hearing protector sold in the United States, real-world tests of hearing protector attenuation are scarce. This study evaluated data from three potential field-test methods as compared with the subject-fit data from Method B of ANSI S12.6-1997 for the E.A.R(R) Express trade mark Pod Plug trade mark. The new field-test methods were the FitCheck headphone (FCH) method, FitCheck in sound field (FCSF) method, and bone-conduction loudness balance (BCLB) method, all of which can be administered in small single-person audiometric booths such as are commonly found in industry. Twenty normal-hearing and audiometrically competent subjects naive to hearing protector use were tested with the laboratory and the three field-test methods in a repeated-measures design. Repeated-measures models with structured covariance matrices were used to analyze the data. Significant effects were found for method, frequency, and first-order frequency-by-gender and frequency-by-method interactions. These effects and interactions were expected given the different psychophysical tasks. The FCSF and BCLB methods provided attenuations that were not significantly different from those found with Method B. Although the attenuations measured for the FCH method were statistically different (greater) than the attenuations from the other methods, the differences were within the magnitude of acceptable test-retest audiometric variability. The results suggest that the FCH and FCSF methods were both feasible and reliable methods for field testing. The FCH method is limited to testing earplugs, and the FCSF requires additional equipment to outfit the test booth, but could be used for testing all types of protectors.
SN - 1542-8117
AD - Hearing Loss Prevention Section, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS C-27, Cincinnati, OH 45226-1998
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106697153
T1 - Behavioral counseling in primary care to promote a healthy diet.
AU - Fink K
AU - Clark B
AU - Fink, Kenneth
AU - Clark, Barbara
Y1 - 2003/07//7/1/2003
N1 - Accession Number: 106697153. Language: English. Entry Date: 20040130. Revision Date: 20161128. Publication Type: journal article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Counseling
KW - Diet
KW - Health Promotion
KW - Primary Health Care
KW - Education, Continuing (Credit)
KW - Family Practice
KW - Health Behavior
KW - Nutrition Education
KW - Preventive Health Care
KW - United States
SP - 147
EP - 172
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 68
IS - 1
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - Putting prevention into practice: an evidence-based approach series
SN - 0002-838X
AD - U.S. Preventive Services Task Force, Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, USA
AD - Program Director, US Preventive Services Task Force, Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality
U2 - PMID: 12887121.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baine, William B.
T1 - Systematic screening of secondary diagnoses in medicare administrative data to identify candidate risk factors for the principal diagnosis
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2003/07//
VL - 13
IS - 6
M3 - Article
SP - 443
SN - 10472797
AB - PURPOSE: Secondary diagnoses in Medicare hospital discharge claims may include risk factors for the principal diagnosis. However, risk ratios for the principal diagnosis as a function of secondary diagnoses cannot be calculated because no comparable data exist for beneficiaries who are not hospitalized.METHODS: Hospital discharge rates, as proxies for incidence rates, can be calculated by race and sex from Medicare claims and denominator files. If the prevalence of a risk factor is higher in one population group than another, that risk factor will be overrepresented among patients from the group at higher risk.RESULTS: This imbalance is reflected in what is termed the odds difference, OD = [(r + r′)/r][f2/(1− f2)−f1/(1−f1)], in which r is the background incidence rate, and r′ is the additional risk conferred by a factor that is present in fractions f1 and f2 in the two groups. Unlike the risk ratio, the odds difference can be calculated from claims data. Given f1 and f2, the odds difference is directly proportional to the risk ratio, RR = (r + r′)/r.CONCLUSIONS: Ranking common secondary diagnoses by the magnitude of their odds difference between groups with disparate discharge rates for a given principal diagnosis may disclose secondary diagnoses that merit evaluation as candidate direct or indirect risk factors. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSIS
KW - DISEASES -- Causes & theories of causation
KW - DISEASES -- Risk factors
KW - Epidemiologic Methods
KW - Medicare Part A
KW - Risk Factors
N1 - Accession Number: 11890089; Baine, William B. 1; Email Address: wbaine@ahrq.gov; Affiliation: 1: From the Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, MD (W.B.B.), USA; Source Info: Jul2003, Vol. 13 Issue 6, p443; Subject Term: DIAGNOSIS; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: DISEASES -- Risk factors; Author-Supplied Keyword: Epidemiologic Methods; Author-Supplied Keyword: Medicare Part A; Author-Supplied Keyword: Risk Factors; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S1047-2797(03)00005-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11890089&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106880681
T1 - Systematic screening of secondary diagnoses in Medicare administrative data to identify candidate risk factors for the principal diagnosis.
AU - Baine WB
Y1 - 2003/07//
N1 - Accession Number: 106880681. Language: English. Entry Date: 20031031. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 9100013.
KW - Data Analysis, Statistical -- Methods
KW - Diagnosis -- Classification
KW - Epidemiology
KW - Medicare -- Administration
KW - Resource Databases -- Utilization
KW - Risk Factors
KW - Aged
KW - Aged, 80 and Over
KW - Billing and Claims
KW - Case Control Studies
KW - Comorbidity
KW - Descriptive Statistics
KW - Diabetes Mellitus
KW - Epidemiological Research
KW - Female
KW - Hypertension
KW - Incidence
KW - Inpatients
KW - International Classification of Diseases
KW - Renal Insufficiency
KW - Lung Diseases, Obstructive
KW - Lung Neoplasms
KW - Male
KW - Myocardial Infarction
KW - Odds Ratio
KW - P-Value
KW - Prospective Studies
KW - Race Factors
KW - Sex Factors
KW - Human
SP - 443
EP - 449
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 13
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: Secondary diagnoses in Medicare hospital discharge claims may include risk factors for the principal diagnosis. However, risk ratios for the principal diagnosis as a function of secondary diagnoses cannot be calculated because no comparable data exist for beneficiaries who are not hospitalized. METHODS: Hospital discharge rates, as proxies for incidence rates, can be calculated by race and sex from Medicare claims and denominator files. If the prevalence of a risk factor is higher in one population group than another, that risk factor will be overrepresented among patients from the group at higher risk. RESULTS: This imbalance is reflected in what is termed the odds difference, OD=[(r+r')/r][f(2)/(1- f(2))-f(1)/(1-f(1))], in which r is the background incidence rate, and r' is the additional risk conferred by a factor that is present in fractions f(1) and f(2) in the two groups. Unlike the risk ratio, the odds difference can be calculated from claims data. Given f(1) and f(2), the odds difference is directly proportional to the risk ratio, RR=(r+r')/r. CONCLUSIONS: Ranking common secondary diagnoses by the magnitude of their odds difference between groups with disparate discharge rates for a given principal diagnosis may disclose secondary diagnoses that merit evaluation as candidate direct or indirect risk factors.
SN - 1047-2797
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Department of Health and Human Services, Suite 300, 6010 Executive Boulevard, Rockville, MD 20852-3813; wbaine@ahrq.gov
U2 - PMID: 12875803.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106880681&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fryer Jr., George F.
AU - Green, Larry A.
AU - Dovey, Susan M.
AU - Yawn, Barbara P
AU - Phillips, Robert L.
AU - Lanier, David
T1 - Variation in the Ecology of Medical Care.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2003/07//
VL - 1
IS - 2
M3 - Article
SP - 81
EP - 89
PB - Annals of Family Medicine
SN - 15441709
AB - Reports on the variation in the medical care delivery with the sociodemographic characteristics and health care arrangements of individual person in the U.S. Link between people and the health care environment; Differences in health care persons with health insurance and source of care; Assessment of the adequacy of health care for the Americans.
KW - MEDICAL care
KW - HEALTH insurance
KW - HEALTH services accessibility
KW - SOCIODEMOGRAPHIC factors
KW - UNITED States
N1 - Accession Number: 14179950; Fryer Jr., George F. 1; Email Address: Efryer@aafp.org; Green, Larry A. 1; Dovey, Susan M. 1; Yawn, Barbara P 2; Phillips, Robert L. 1; Lanier, David 3; Source Information: Jul2003, Vol. 1 Issue 2, p81; Subject: MEDICAL care; Subject: HEALTH insurance; Subject: HEALTH services accessibility; Subject: SOCIODEMOGRAPHIC factors; Geographic Terms: UNITED States; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Davis, Christy
AU - Park, Miseon
AU - Heinze, Thomas M.
AU - Beger, Richard D.
T1 - Variations in metabolism of the soy isoflavonoid daidzein by human intestinal microfloras from different individuals.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2003/07//
VL - 180
IS - 1
M3 - Article
SP - 11
EP - 16
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - Isoflavonoids found in legumes, such as soybeans, are converted by intestinal bacteria to metabolites that might have increased or decreased estrogenic activity. Variation in the effects of dietary isoflavonoids among individuals has been attributed to differences in their metabolism by intestinal bacteria. To investigate this variation, the metabolism of the isoflavonoid daidzein by bacteria from ten fecal samples, provided at different times by six individuals on soy-containing diets, was compared. After anaerobic incubation of bacteria with daidzein for 2 weeks, four samples had metabolized daidzein and six samples had not. Three of the positive samples were from individuals whose microflora had not metabolized daidzein in previous samples. Dihydrodaidzein was observed in one sample, dihydrodaidzein and equol in another sample, and equol and O-desmethylangolensin in two other samples. These results corroborate the hypothesis that the microflora of the gastrointestinal tract of an individual influences the particular isoflavone metabolites produced following consumption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological products
KW - Metabolism
KW - Gastrointestinal system
KW - Biochemistry
KW - Anaerobiosis
KW - Consumption (Economics)
KW - Daidzein
KW - Equol
KW - Intestinal bacteria
KW - Isoflavonoids
N1 - Accession Number: 16867461; Rafii, Fatemeh 1; Email Address: frafii@nctr.fda.gov; Davis, Christy 2; Park, Miseon 1; Heinze, Thomas M. 3; Beger, Richard D. 3; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, AR 72079, Jefferson, USA.; 2: Dollarway High School, AR 71602, Pine Bluff, USA.; 3: Division of Chemistry, National Center for Toxicological Research, U.S. FDA, AR 72079, Jefferson, USA.; Issue Info: Jul2003, Vol. 180 Issue 1, p11; Thesaurus Term: Biological products; Subject Term: Metabolism; Subject Term: Gastrointestinal system; Subject Term: Biochemistry; Subject Term: Anaerobiosis; Subject Term: Consumption (Economics); Author-Supplied Keyword: Daidzein; Author-Supplied Keyword: Equol; Author-Supplied Keyword: Intestinal bacteria; Author-Supplied Keyword: Isoflavonoids; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/s00203-003-0551-6
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106717256
T1 - Serious asthma exacerbations in asthmatics treated with high-dose formoterol.
AU - Mann M
AU - Chowdhury B
AU - Sullivan E
AU - Nicklas R
AU - Anthracite R
AU - Meyer RJ
Y1 - 2003/07//
N1 - Accession Number: 106717256. Language: English. Entry Date: 20040326. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0231335.
KW - Adrenergic Beta-Agonists -- Administration and Dosage
KW - Adrenergic Beta-Agonists -- Adverse Effects
KW - Asthma -- Drug Therapy
KW - Disease Exacerbation -- Etiology
KW - Drugs, Investigational -- Administration and Dosage
KW - Drugs, Investigational -- Adverse Effects
KW - Administration, Inhalation
KW - Adolescence
KW - Adult
KW - Aged
KW - Child
KW - Double-Blind Studies
KW - Drug Approval
KW - Female
KW - Forced Expiratory Volume
KW - Male
KW - Middle Age
KW - Placebos
KW - United States Food and Drug Administration
KW - Human
SP - 70
EP - 74
JO - CHEST
JF - CHEST
JA - CHEST
VL - 124
IS - 1
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - OBJECTIVE: To review three prospective, randomized, placebo-controlled, double-blind clinical studies of formoterol (Foradil Aerolizer; Novartis Pharmaceuticals; Basel, Switzerland) at dosages of 12 microg and 24 microg bid for the treatment of patients with asthma. DATA SOURCES: Clinical studies submitted to the US Food and Drug Administration in support of the approval of Foradil Aerolizer for marketing in the United States. RESULTS: More patients treated regularly with formoterol, 24 micro g bid, had a serious asthma exacerbation than did patients who had been treated with placebo. In the first study, 4 of 135 adult patients (3%) who had been treated with formoterol, 24 microg bid, had a serious asthma exacerbation compared to none of 136 placebo-treated patients. In the second study, 5 of 136 patients (3.7%) treated with formoterol, 24 microg bid, had a serious asthma exacerbation compared to 2 of 141 placebo-treated patients (1.4%). In the third study, 11 of 171 pediatric patients (6.4%) treated with formoterol, 24 microg bid, had a serious asthma exacerbation compared to none of 176 placebo-treated patients. CONCLUSION: Regular use of high-dose inhaled formoterol (24 microg bid) may be associated with more frequent serious asthma exacerbations.
SN - 0012-3692
AD - Division of Pulmonary and Allergy Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Ln, Rockville, MD 20857; mannm@cder.fda.gov
U2 - PMID: 12853504.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 107927746
T1 - Meal-Planning Strategies: Ethnic Populations.
AU - Brown, Tammy L.
Y1 - 2003///Summer2003
N1 - Accession Number: 107927746. Language: English. Entry Date: 20140107. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8913432.
KW - Menu Planning
KW - Cultural Sensitivity
KW - Nutritional Counseling
KW - Diabetes Education
KW - Cultural Competence
KW - Diabetic Diet
KW - Ethnic Groups
SP - 190
EP - 192
JO - Diabetes Spectrum
JF - Diabetes Spectrum
JA - DIABETES SPECTRUM
VL - 16
IS - 3
CY - Alexandria, Virginia
PB - American Diabetes Association
SN - 1040-9165
AD - Nutrition consultant, Indian Health Service National Diabetes Program in Albuquerque, N.M.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lidz, Charles W.
AU - Parker, Lisa S.
T1 - Issues of Ethics and Identity in Diagnosis of Late Life Depression.
JO - Ethics & Behavior
JF - Ethics & Behavior
Y1 - 2003/07//
VL - 13
IS - 3
M3 - Article
SP - 249
PB - Taylor & Francis Ltd
SN - 10508422
AB - Depression is often diagnosed in patients nearing the end of their lives and medication or psychotherapy is prescribed. In many cases this is appropriate. However, it is widely agreed that a health care professional should treat sick persons so as to improve their condition as they define improvement. This raises questions about the contexts in which treatment of depression in late life is appropriate. This article reviews a problematic case concerning the appropriateness of treatment in light of the literature in bioethics. Specific attention is paid to the concept of authenticity and the role of suffering. Suffering is often the result of a situation in which one's self is damaged. In some circumstances, this suffering should not be seen as a symptom of illness but as a reflection, in a difficult life context, of the individual's authentic nature. Assessment of depression in the elderly must go beyond a symptom list and must consider both the context of the individual's situation and his or her authentic self. When the symptoms reflect the individual's assessment of the situation in the context of the authentic self, they may be "appropriate." However, even when the symptoms are appropriate, if they interfere with life assessment and adjustment, treatment should be considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Ethics & Behavior is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression
KW - PSYCHOTHERAPY
KW - SUFFERING
KW - BIOETHICS
KW - depression
KW - diagnosis
KW - ethics
KW - late life
N1 - Accession Number: 11021105; Lidz, Charles W. 1 Parker, Lisa S. 2; Affiliation: 1: Center for Mental Health Services Research, University of Massachusetts Medical School 2: Center for Bioethics and Health Law, University of Pittsburgh; Source Info: Jul2003, Vol. 13 Issue 3, p249; Subject Term: MENTAL depression; Subject Term: PSYCHOTHERAPY; Subject Term: SUFFERING; Subject Term: BIOETHICS; Author-Supplied Keyword: depression; Author-Supplied Keyword: diagnosis; Author-Supplied Keyword: ethics; Author-Supplied Keyword: late life; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, S.Y.
AU - Kim, J.S.
AU - Kim, M.
AU - Hong, M.K.
AU - Lee, J.O.
AU - Kim, C.M.
AU - Song, I.S.
T1 - Survey of nitrate and nitrite contents of vegetables grown in Korea.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2003/07//
VL - 20
IS - 7
M3 - Article
SP - 621
PB - Taylor & Francis Ltd
SN - 0265203X
AB - A scientific basis for the evaluation of the risk to public health arising from excessive dietary intake of nitrate in Korea is provided. The nitrate ( ) and nitrite ( ) contents of various vegetables (Chinese cabbage, radish, lettuce, spinach, soybean sprouts, onion, pumpkin, green onion, cucumber, potato, carrot, garlic, green pepper, cabbage and Allium tuberosum Roth known as Crown daisy) are reported. Six hundred samples of 15 vegetables cultivated during different seasons were analysed for nitrate and nitrite by ion chromatography and ultraviolet spectrophotometry, respectively. No significant variance in nitrate levels was found for most vegetables cultivated during the summer and winter harvests. The mean nitrates level was higher in A. tuberosum Roth (5150 mg kg -1 ) and spinach (4259 mg kg -1 ), intermediate in radish (1878 mg kg -1 ) and Chinese cabbage (1740 mg kg -1 ), and lower in onion (23 mg kg -1 ), soybean sprouts (56 mg kg -1 ) and green pepper (76 mg kg -1 ) compared with those in other vegetables. The average nitrite contents in various vegetables were about 0.6 mg kg -1 , and the values were not significantly different among most vegetables. It was observed that nitrate contents in vegetables varied depending on the type of vegetables and were similar to those in vegetables grown in other countries. From the results of our studies and other information from foreign sources, it can be concluded that it is not necessary to establish limits of nitrates contents of vegetables cultivated in Korea due to the co-presence of beneficial elements such as ascorbic acid and α-tocopherol which are known to inhibit the formation of nitrosamine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitrates
KW - Food contamination
KW - Public health
KW - Korea (South)
KW - dietary intake
KW - nitrate
KW - nitrite
KW - vegetables
N1 - Accession Number: 10466541; Chung, S.Y. 1; Email Address: sychung@kfda.go.kr; Kim, J.S. 1; Kim, M. 1; Hong, M.K. 1; Lee, J.O. 1; Kim, C.M. 1; Song, I.S. 1; Affiliations: 1: Korea Food and Drug Administration, Department of Food Evaluation; Issue Info: Jul2003, Vol. 20 Issue 7, p621; Thesaurus Term: Nitrates; Thesaurus Term: Food contamination; Thesaurus Term: Public health; Subject: Korea (South); Author-Supplied Keyword: dietary intake; Author-Supplied Keyword: nitrate; Author-Supplied Keyword: nitrite; Author-Supplied Keyword: vegetables; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hammack, Thomas S.
AU - Amaguaña, R. Miguel
AU - Johnson, Mildred L.
AU - Andrews, Wallace H.
T1 - Effectiveness of Universal Pre-enrichment Broth for Recovery of Salmonella from Selected Dairy Foods.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/07//Jul/Aug2003
VL - 86
IS - 4
M3 - Article
SP - 714
EP - 718
SN - 10603271
AB - Compares the relative efficiencies of 2 Bacteriological Analytical Manual pre-enrichments, lactose broth (LAC) and brilliant green water (BGW), with Universal Pre-enrichment (UP) broth for the recovery of Salmonella serovars from instant nonfat dry milk. Recovery rates; Culture method for selected dairy foods.
KW - ANALYTICAL chemistry
KW - MILK
N1 - Accession Number: 10879264; Hammack, Thomas S. 1; Email Address: thomas.hammack@cfsan.fda.gov Amaguaña, R. Miguel 1 Johnson, Mildred L. 1 Andrews, Wallace H. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Microbiological Studies, MD; Source Info: Jul/Aug2003, Vol. 86 Issue 4, p714; Subject Term: ANALYTICAL chemistry; Subject Term: MILK; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volpe, Donna A.
AU - Ellison, Christopher D.
AU - Parchment, Ralph E.
AU - Grieshaber, Charles K.
AU - Faustino, Patrick J.
T1 - Effects of amitriptyline and fluoxetine upon the in vitro proliferation of tumor cell lines.
JO - Journal of Experimental Therapeutics & Oncology
JF - Journal of Experimental Therapeutics & Oncology
Y1 - 2003/07//
VL - 3
IS - 4
M3 - Article
SP - 169
PB - Old City Publishing, Inc.
SN - 13594117
AB - Previous publications have suggested that commonly prescribed antidepressants have the potential to stimulate the proliferation of extant tumors in human and rodent in vivo and in vitro models. The direct effects of amitriptyline and fluoxetine were evaluated in assays that detect different aspects of proliferative responses at pharmacologically relevant drug concentrations. Three in vitro assays of cellular proliferation and clonal growth were used with human (MCF7, PA-1 and LS174T) and murine (B16.f10, C-3 and B16.f1) tumor cell lines. The cells were exposed to amitriptyline or fluoxetine (0.001–100 μM) for different time periods (1–7 days) and at varying serum concentrations (0.1–15%). Amitriptyline and fluoxetine failed to significantly stimulate tumor cell proliferation, DNA synthesis, or colony formation. Both drugs inhibited B16.f10 colony growth at concentrations above 5 μM along with significant suppression of DNA synthesis in B16.f10 and C-3 cells at 30 μM. Although there were generally no effects on cell proliferation by the drugs in the microtiter tetrazolium assay, several rare instances of stimulation were noted. Amitriptyline and fluoxetine were consistent in their lack of effect or inhibition with the human or murine tumor cell lines in conventional in vitro assays of cell proliferation and clonogenicity in optimal or suboptimal culture conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Experimental Therapeutics & Oncology is the property of Old City Publishing, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUOXETINE
KW - CANCER cells
KW - Amitriptyline
KW - fluoxetine
KW - in vitro assays
KW - tumor cell proliferation
N1 - Accession Number: 10857235; Volpe, Donna A. 1; Email Address: volpe@cder.fda.gov Ellison, Christopher D. 1 Parchment, Ralph E. 1,2 Grieshaber, Charles K. 1,3 Faustino, Patrick J. 1; Affiliation: 1: Office of testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, U.S.A. 2: Karmanos Cancer Institute, Detroit, MI, U.S.A. 3: Xanthus Life Science, Inc. Cambridge, MA, U.S.A.; Source Info: Jul2003, Vol. 3 Issue 4, p169; Subject Term: FLUOXETINE; Subject Term: CANCER cells; Author-Supplied Keyword: Amitriptyline; Author-Supplied Keyword: fluoxetine; Author-Supplied Keyword: in vitro assays; Author-Supplied Keyword: tumor cell proliferation; Number of Pages: 16p; Document Type: Article
L3 - 10.1046/j.1359-4117.2003.01091.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flint, Melanie S.
AU - Depree, Karyn M.
AU - Rich, Brenda A.
AU - Tinkle, Sally S.
T1 - Differential regulation of sensitizer-induced inflammation and immunity by acute restraint stress in allergic contact dermatitis
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
Y1 - 2003/07//
VL - 140
IS - 1/2
M3 - Article
SP - 28
SN - 01655728
AB - Previously, we demonstrated that restraint stress applied before chemical sensitization modulates allergic contact dermatitis (ACD) differently than restraint applied before challenge. In this study, we asked if these dichotomous restraint-induced changes reflect modulation of the cutaneous microenvironment or changes in development of antigen-specific immunity in the lymph node (LN) of BALB/c mice. Our data confirm that restraint suppresses T cell-dependent immunity in ACD when applied prior to sensitization or prior to challenge and demonstrate that the stress-induced increase in ear swelling is due to heightened inflammation associated with ACD and is dependent upon the sensitization status of the mouse. [Copyright &y& Elsevier]
AB - Copyright of Journal of Neuroimmunology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - ALLERGY
KW - ANTIGENS
KW - Inflammation
KW - Langerhans cell
KW - Neuroimmunology
KW - Sensitization
KW - Skin
N1 - Accession Number: 10233420; Flint, Melanie S. 1 Depree, Karyn M. 1 Rich, Brenda A. 1 Tinkle, Sally S.; Email Address: sft3@cdc.gov; Affiliation: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA; Source Info: Jul2003, Vol. 140 Issue 1/2, p28; Subject Term: CONTACT dermatitis; Subject Term: ALLERGY; Subject Term: ANTIGENS; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Langerhans cell; Author-Supplied Keyword: Neuroimmunology; Author-Supplied Keyword: Sensitization; Author-Supplied Keyword: Skin; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0165-5728(03)00163-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106714132
T1 - Guest editorial. How to report nonsignificant results: frequently asked questions.
AU - Derr J
AU - Goldsmith LJ
Y1 - 2003/07//2003 Jul
N1 - Accession Number: 106714132. Language: English. Entry Date: 20040319. Revision Date: 20150711. Publication Type: Journal Article; editorial; questions and answers. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7908150.
KW - Writing for Publication
KW - Study Design
KW - Statistical Significance
KW - Data Analysis, Statistical
SP - 367
EP - 368
JO - Journal of Orthopaedic & Sports Physical Therapy
JF - Journal of Orthopaedic & Sports Physical Therapy
JA - J ORTHOP SPORTS PHYS THER
VL - 33
IS - 7
CY - La Crosse, Wisconsin
PB - American Physical Therapy Association, Orthopaedic Section
SN - 0190-6011
AD - US Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Adler, Michael
AU - Shafer, Harlan F.
AU - Manley, Heather A.
AU - Hackley Jr., Brennie E.
AU - Nicholson, James D.
AU - Keller, James E.
AU - Goodnough, Michael C.
T1 - A Capillary Electrophoresis Technique for Evaluating Botulinum Neurotoxin B Light Chain Activity.
JO - Journal of Protein Chemistry
JF - Journal of Protein Chemistry
Y1 - 2003/07//
VL - 22
IS - 5
M3 - Article
SP - 441
EP - 448
SN - 02778033
AB - Botulinum neurotoxin B (BoNT/B) produces muscle paralysis by cleaving synaptobrevin/vesicleassociated membrane protein (VAMP), an 18-kDa membrane-associated protein located on the surface of small synaptic vesicles. A capillary electrophoresis (CE) assay was developed to evaluate inhibitors of the proteolytic activity of BoNT/B with the objective of identifying suitable candidates for treatment of botulism. The assay was based on monitoring the cleavage of a peptide that corresponds to residues 44-94 of human VAMP-2 (V51) following reaction with the catalytic light chain (LC) of BoNT/B. Cleavage of V51 generated peptide fragments of 18 and 33 amino acids by scission of the bond between Q76 and F77. The fragments and parent peptide were clearly resolved by CE, allowing accurate quantification of the BoNT/B LC-mediated reaction rates. The results indicate that CE is suitable for assessing the enzymatic activity of BoNT/B LC. KEY WORDS: Botulinum neurotoxin B; Clostridium botulinum; capillary electrophoresis; VAMP/synaptobrevin; enzymatic cleavage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Protein Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAPILLARY electrophoresis
KW - BOTULINUM toxin
KW - MEMBRANE proteins
KW - BOTULISM
KW - PEPTIDES
KW - ENZYMES
N1 - Accession Number: 11644299; Adler, Michael 1; Email Address: Michael.Adler@amedd.army.mil Shafer, Harlan F. 1 Manley, Heather A. 1 Hackley Jr., Brennie E. 2 Nicholson, James D. 1 Keller, James E. 3 Goodnough, Michael C. 4; Affiliation: 1: Neurotoxicity Branch, Pharmacology Division, U.S. Army Medical Research Institute of Chemical Defense, Maryland 2: Office of the Commander, U.S. Army Medical Research Institute of Chemical Defense, Maryland 3: Laboratory of Bacterial Toxins, CEBER, Food and Drug Administration, Maryland 4: Department of Food Microbiology, Food Research Institute, University of Wisconsin; Source Info: Jul2003, Vol. 22 Issue 5, p441; Subject Term: CAPILLARY electrophoresis; Subject Term: BOTULINUM toxin; Subject Term: MEMBRANE proteins; Subject Term: BOTULISM; Subject Term: PEPTIDES; Subject Term: ENZYMES; Number of Pages: 8p; Illustrations: 1 Chart, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zgoba, Kristen M.
AU - Sager, Wayne R.
AU - Witt, Phillip H.
T1 - Evaluation of New Jersey's sex offender treatment program at the Adult Diagnostic and Treatment Center: preliminary results.
JO - Journal of Psychiatry & Law
JF - Journal of Psychiatry & Law
Y1 - 2003///Summer2003
VL - 31
IS - 2
M3 - Article
SP - 133
EP - 164
PB - Sage Publications Inc.
SN - 00931853
AB - This study examined 10-year sexual and non-sexual offense recidivism for sex offenders released from New Jersey's general prison system and from the Adult Diagnostic and Treatment Center (ADTC), New Jersey's correctional facility and treatment center for repetitive-compulsive sexual offenders. The study found that sexual offenders released from the ADTC had significantly lower rates of committing both non-sexual offenses and any offense, compared with the general prison population of sex offenders. For both groups, the 10-year sexual offense reconviction rates were relatively low, 8.6% for the ADTC offenders and 12.7% for the general prison sexual offenders, while reoffense rates for non-sexual offenses were 25.8% and 44.1% for ADTC and general prison sex offenders, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Psychiatry & Law is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RECIDIVISM
KW - SEX crimes
KW - SEX offenders
KW - PRISON sentences
KW - PRISON administration
N1 - Accession Number: 11335863; Zgoba, Kristen M. 1 Sager, Wayne R. 2,3 Witt, Phillip H. 4,5,6,7; Affiliation: 1: Center for Mental Health Services and Criminal Justice Research, Rutgers University 2: Program development specialist and research coordinator, Adult Diagnostic and Treatment Center, New Jersey 3: Adjunct instructor in psychology, College of New Jersey 4: Principal, Associates in Psychological Services, P. A. 5: Diplomate in forensic psychology, American Board of Professional Psychology 6: Clinical associate professor, Robert Wood Johnson Medical School--UMDNJ 7: Adjunct faculty member, Graduate School of Applied and Professional Psychology, Rutgers University; Source Info: Summer2003, Vol. 31 Issue 2, p133; Subject Term: RECIDIVISM; Subject Term: SEX crimes; Subject Term: SEX offenders; Subject Term: PRISON sentences; Subject Term: PRISON administration; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 32p; Illustrations: 9 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The effect of trabecular material properties on the frequency dependence of backscatter from cancellous bone (L).
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2003/07//
VL - 114
IS - 1
M3 - Article
SP - 62
EP - 65
SN - 00014966
AB - Previous experimental studies indicate that backscatter coefficient for human calcaneal trabecular bone varies approximately as frequency cubed. This frequency dependence has been shown to be consistent with a model in which trabeculae are thought of as long thin cylinders composed of a substance with the same material properties as hydroxyapatite. The true material properties of human trabecular bone are not known however. Based on reported measurements of material properties of many bones and bonelike substances, it is possible that the density and longitudinal sound speed of trabecular bone material are far lower than the hydroxyapatite model would suggest. In this letter, it is shown that the frequency dependence of backscatter is still expected to be approximately cubic for wide ranges for density and longitudinal sound speed (encompassing the conceivable ranges for trabecular bone). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPEED of sound
KW - BACKSCATTERING
KW - HYDROXYAPATITE
KW - BONES
KW - MATTER -- Properties
N1 - Accession Number: 20665981; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142, 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Jul2003, Vol. 114 Issue 1, p62; Subject Term: SPEED of sound; Subject Term: BACKSCATTERING; Subject Term: HYDROXYAPATITE; Subject Term: BONES; Subject Term: MATTER -- Properties; Number of Pages: 4p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1121/1.1554692
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chanmugam, Prithiva
AU - Guthrie, Joanne F.
AU - Cecilio, Salvadore
AU - Morton, Joan F.
AU - Basiotis, P.Peter
AU - Anand, Rajen
T1 - ▪Did fat intake in the United States really decline between 1989-1991 and 1994-1996?
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2003/07//
VL - 103
IS - 7
M3 - Article
SP - 867
EP - 872
SN - 00028223
AB - Abstract: The objectives of this study were to determine changes in fat and energy intakes in the United States between 1989-1991 and 1994-1996, and to examine the implications of expressing fat intake in grams vs as a percent of total energy intake. The source of data was the Continuing Survey of Food Intake by Individuals. The results suggest that intake of energy rose between the 2 time periods, primarily due to higher carbohydrate intake. There was also a modest increase in fat intake. However fat intake, as a percent of total energy, declined. The higher energy intakes were primarily from beverages, especially soft drinks, food mixtures, grain snacks, and pastries. The primary sources of higher fat intakes were meat mixtures, vegetables, and some categories of the grain group. Similar trends in the Food Supply Series suggested that the changes observed were not entirely due to changes in survey methodology. Because the increase in fat intake was masked by the increase in energy intake, we conclude that assessing trends in fat intake as a percent of energy consumption can be misleading, unless information on total energy and fat intake, in grams, is also provided. These preliminary findings should be interpreted cautiously until they are confirmed by formal secular trend analyses. J Am Diet Assoc. 2003;103:867-872. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Dietetic Association is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food industry
KW - Fat
KW - Beverages
KW - United States
N1 - Accession Number: 22281118; Chanmugam, Prithiva 1; Guthrie, Joanne F. 1; Cecilio, Salvadore 1; Morton, Joan F. 1; Basiotis, P.Peter 1; Anand, Rajen 1; Affiliations: 1: P. Chanmugam is an assistant professor in the School of Human Ecology, Louisiana State University, Baton Rouge. J. F. Guthrie is assistant deputy director, Economic Research Service, US Department of Agriculture, Washington, DC. S. Cecilio was an intern with the Center for Food Safety and Applied Nutrition within the Food and Drug Administration, Washington, DC. J. F. Morton is a program analyst with the Veterans Health Administration, Department of Veterans Affairs, Washington, DC. P. P. Basiotis is the director and R. Anand is the former executive director of the Center for Nutrition Policy and Promotion, US Department of Agriculture, Washington, DC; Issue Info: Jul2003, Vol. 103 Issue 7, p867; Thesaurus Term: Food industry; Subject Term: Fat; Subject Term: Beverages; Subject: United States; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106697766
T1 - Vitamin-mineral supplement use among US women, 2000.
AU - Yu SM
AU - Kogan MD
AU - Huang ZJ
Y1 - 2003///Summer2003
N1 - Accession Number: 106697766. Language: English. Entry Date: 20040130. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503064.
KW - Dietary Supplementation
KW - Vitamins -- Therapeutic Use
KW - Blacks
KW - Body Mass Index
KW - Chi Square Test
KW - Confidence Intervals
KW - Data Analysis Software
KW - Demography
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Exercise
KW - Geographic Factors
KW - Health Behavior
KW - Health Status
KW - Hispanics
KW - Logistic Regression
KW - Odds Ratio
KW - Secondary Analysis
KW - United States
KW - Whites
KW - Human
SP - 157
EP - 164
JO - Journal of the American Medical Women's Association
JF - Journal of the American Medical Women's Association
JA - J AM MED WOMENS ASSOC
VL - 58
IS - 3
CY - Reston, Virginia
PB - American Medical Women's Association
AB - OBJECTIVE: To examine the prevalence of vitamin-mineral supplement use and its association with sociodemographic, health status, and health behavior characteristics in a nationally representative sample of US women. METHODS: We analyzed the cancer supplement file of the 2000 National Health Interview Survey, which included 11,888 non-Hispanic white, 2866 non-Hispanic black, 3035 Hispanic, and 599 non-Hispanic other women. Bivariate and multivariate analyses were conducted to examine the relationships between sociodemographic, health status, and health behavior characteristics and the use of selected vitamin-mineral supplements. RESULTS: Nearly 60% of US women took at least one supplement in 2000. Logistic regression showed that women who were non-Hispanic white, married, older, more educated, not poor, former smokers, alcohol users, and regular exercisers were significantly more likely to take the most commonly reported vitamin-mineral supplements. Women who were obese or overweight and women who had not had contact with a health professional in the past 12 months were less likely to use supplements. CONCLUSION: Our study suggests high levels of vitamin-mineral supplement use among US women. Supplement use was generally associated with a healthier lifestyle and more resources. Our data suggest the need for public health education on the benefits of age- and health-appropriate use of supplements.
SN - 0098-8421
AD - Epidemiologist, Maternal and Child Health Bureau, Office of Data and Information Management; syu@hrsa.gov
U2 - PMID: 12948107.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106734591
T1 - Demographic variation in SF-12 scores: true differences or differential item functioning?
AU - Fleishman JA
AU - Lawrence WF
Y1 - 2003/07//
N1 - Accession Number: 106734591. Language: English. Entry Date: 20040514. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Short Form 12 Health Survey (SF-12). Grant Information: Agency for Healthcare Research and Quality, Rockville, MD. NLM UID: 0230027.
KW - Age Factors
KW - Educational Status
KW - Health Status
KW - Mental Status
KW - Race Factors
KW - Sex Factors
KW - Differential Item Functioning
KW - Adult
KW - Aged
KW - Blacks
KW - Chi Square Test
KW - Factor Analysis
KW - Female
KW - Goodness of Fit Chi Square Test
KW - Hispanics
KW - Male
KW - Middle Age
KW - Regression
KW - Research Instruments
KW - Structural Equation Modeling
KW - Survey Research
KW - Two-Tailed Test
KW - Whites
KW - Funding Source
KW - Human
SP - III
EP - 75
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 41
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Demographic differences have been reported in summary measures of physical and mental health based on the SF-12 instrument. OBJECTIVES: This study examines the extent to which differential item functioning (DIF) contributes to observed subgroup differences in health status. DIF refers to situations in which the psychometric properties of items are not invariant across different groups. The presence of DIF confounds interpretation of subgroup differences. SUBJECTS: A national sample of 11,626 adult respondents in the 2000 Medical Expenditure Panel Survey who completed a self-administered questionnaire. MEASURES: In addition to the SF-12, we collected data on demographic characteristics (age, gender, education, and race/ethnicity) and whether the person had ever been diagnosed with six chronic medical conditions. RESULTS: Multiple-indicator multiple-cause latent variable models showed significant differences in physical health by gender, age, and education. Adjusting for DIF reduced but did not eliminate age and education differences. However, for mental health, adjusting for DIF resulted in Black-White differences becoming nonsignificant, and the effect for the oldest age group switched from positive to negative. Race/ethnicity was not associated with physical health status. CONCLUSIONS: Age group comparisons of mental health may be particularly affected by DIF. Differences in education, as well as age and gender, need to be controlled when making group comparisons. Additional work is needed to understand factors that give rise to demographic differences in reported health status.
SN - 0025-7079
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 2101 East Jefferson St, Rockville, MD 20852; jfleishm@ahrq.gov
U2 - PMID: 12865729.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106734589
T1 - Health care expenditure burdens among elderly adults: 1987 and 1996.
AU - Selden TM
AU - Banthin JS
Y1 - 2003/07//
N1 - Accession Number: 106734589. Language: English. Entry Date: 20040514. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Gerontologic Care -- Economics
KW - Health Care Costs -- In Old Age
KW - Medicaid
KW - Medicare
KW - Aged
KW - Blacks
KW - Descriptive Statistics
KW - Female
KW - Hispanics
KW - Insurance, Health
KW - Male
KW - Race Factors
KW - Sex Factors
KW - Survey Research
KW - Whites
KW - Human
SP - III
EP - 13
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 41
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: Concerns about the health care expenditure burdens of elderly adults underlie the ongoing debate over expanding Medicare benefits and strengthening Medicare+Choice. We examine burdens for this population using data from the 1987 National Medical Expenditure Survey (NMES) and the 1996 Medical Expenditure Panel Survey (MEPS). METHODS: We estimate how frequently elderly adults live in families whose health expenditures exceed 20% or 40% of their after-tax disposable incomes. Our methodology reduces bias due to errors in income while providing an intuitive measure of exposure to the risk of high burdens. RESULTS: Despite rapid increases in medical care prices, the percentage of elderly adults facing burdens over 20% of disposable income remained essentially constant at 20.9% in 1987 and 22.9% in 1996. The percentage with burdens exceeding 40% of disposable income was 7.3% in 1987 and 7.9% in 1996. High expenditure burdens were more prevalent among elderly adults who were poorer, older, female, higher risk, and covered only by traditional Medicare. Medicaid coverage helped to reduce burdens among the elderly poor, yet incomplete Medicaid take-up in 1996 left approximately 1.3 million elderly adults eligible for Medicaid but covered only by traditional Medicare. CONCLUSIONS: Our results highlight the widespread prevalence of high health care expenditure burdens among elderly adults and the varying extent to which insurance coverage helped to protect them from rising health care expenditures between 1987 and 1996.
SN - 0025-7079
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; tselden@ahrq.gov
U2 - PMID: 12865723.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - B.L. Parsons
AU - V.N. Dobrovolsky
AU - P.B. McKinzie
AU - J.G. Shaddock
AU - R.A. Mittelstaedt
AU - R.H. Heflich
T1 - Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk+/- transgenic mice.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2003/07//
VL - 18
IS - 4
M3 - Article
SP - 365
EP - 370
PB - Oxford University Press / USA
SN - 02678357
AB - The effects of deficiency in the DNA mismatch repair (MMR) protein Pms2 were investigated using the endogenous mouse Hprt and Tk genes as reporters of intragenic mutation and loss of heterozygosity (LOH). Pms2-/-Tk+/-, Pms2+/+Tk+/-, Pms2+/-Tk+/- and Pms2-/-Tk-/- mice were bred from Pms2+/-Tk+/- mice. At 2 months of age, the body weight and splenic T lymphocyte yields were significantly lower in Pms2-/-Tk-/- mice than in littermates of the other genotypes. The mice were evaluated for their spontaneous mutant frequencies in the Hprt and Tk genes of splenic lymphocytes and their frequency of micronuclei in polychromatic erythrocytes from bone marrow. The cloning efficiency of lymphocytes derived from Pms2-/-Tk-/- animals was 12-fold lower than that of animals of the other genotypes. Compared with Pms2+/+ and Pms2+/- mice, Pms2-/- mice had a 21- to 69-fold increase in the Hprt mutant frequency. The Hprt mutant frequency was equally high in Pms2-deficient, Tk+/- and Tk-/- mice. No significant Pms2-dependent change in mutant frequency was detected using the Tk mutational target. When individual Tk mutants were analyzed for LOH mutation by allele-specific genotyping, the fraction of LOH mutants was lower in Pms2-deficient than in Pms2-proficient mice (29.2 and 43.6%, respectively). The frequency of bone marrow micronuclei was significantly higher in Pms2-/-Tk-/- mice than in Pms2-/-Tk+/- mice. These observations suggest that the simultaneous occurrence of Tk and Pms2 deficiencies may cause a decrease in cell viability that diminishes the Tk mutational response, making it impossible to discern clearly the effect of Pms2 deficiency on LOH-type mutation using the Tk reporter system. The interaction between Tk deficiency and a component of the MMR system suggests that Tk-deficient cells may have higher levels of DNA polymerase misincorporation or endogenous DNA damage than Tk-proficient cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Genetics
KW - Heterozygosity
N1 - Accession Number: 10403749; B.L. Parsons 1; V.N. Dobrovolsky 2; P.B. McKinzie 2; J.G. Shaddock 2; R.A. Mittelstaedt 2; R.H. Heflich 2; Affiliations: 1: To whom correspondence should be addressed. Tel: +1 870 543 7946; Fax: +1 870 543 7393; Email: bparsons@nctr.fda.gov; 2: Division of Genetic and Reproductive Toxicology, HFT-120, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Jul2003, Vol. 18 Issue 4, p365; Thesaurus Term: Mutation (Biology); Thesaurus Term: Genetics; Subject Term: Heterozygosity; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106858063
T1 - Device safety. Could that plastic device harm your patient?
AU - Alonge LA
Y1 - 2003/07//
N1 - Accession Number: 106858063. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Acids, Carbocyclic -- Adverse Effects
KW - Biomedical and Dental Materials -- Adverse Effects
KW - Environmental Exposure -- Prevention and Control
KW - Equipment Safety
KW - Adolescence
KW - Adult
KW - Child
KW - Child, Preschool
KW - Female
KW - Fetus
KW - Infant, Newborn
KW - Information Resources
KW - Male
KW - Polyvinyls
KW - Pregnancy
KW - Risk Factors
SP - 70
EP - 70
JO - Nursing
JF - Nursing
JA - NURSING
VL - 33
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Biologist, Issue Management, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 12862021.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dingley, Karen H.
AU - Ubick, Esther A.
AU - Chiarappa-Zucca, Marina L.
AU - Nowell, Susan
AU - Abel, Steffen
AU - Ebeler, Susan E.
AU - Mitchell, Alyson E.
AU - Burns, Stephanie A.
AU - Steinberg, Francene M.
AU - Clifford, Andrew J.
T1 - Effect of Dietary Constituents With Chemopreventive Potential on Adduct Formation of a Low Dose of the Heterocyclic Amines PhIP and IQ and Phase II Hepatic Enzymes.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2003/07//
VL - 46
IS - 2
M3 - Article
SP - 212
EP - 221
PB - Taylor & Francis Ltd
SN - 01635581
AB - We conducted a study to evaluate dietary chemopreventive strategies to reduce genotoxic effects of the carcinogens 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). PhIP and IQ are heterocyclic amines (HCAs) that are found in cooked meat and may be risk factors for cancer. Typical chemoprevention studies have used carcinogen doses many thousand-fold higher than usual human daily intake. Therefore, we administered a low dose of [14C] PhIPand [3H] IQand utilized accelerator mass spectrometry to quantify PhIP adducts in the liver, colon, prostate, and blood plasma and IQadducts in the liver and blood plasma with high sensitivity. Diets supplemented with phenethylisothiocyanate (PEITC), genistein, chlorophyllin, or lycopene were evaluated for their ability to decrease adduct formation of [14C] PhIPand [3H] IQin rats. We also examined the effect of treatments on the activity of the phase II detoxification enzymes glutathione S-transferase (GST), UDP-glucuronyltransferase (UGT), phenol sulfotransferase (SULT) and quinone reductase (QR). PEITC and chlorophyllin significantly decreased PhIP-DNA adduct levels in all tissues examined, which was reflected by similar changes in PhIP binding to albumin in the blood. In contrast, genistein and lycopene tended to increase PhIP adduct levels. The treatments did not significantly alter the level of IQ-DNA or -protein adducts in the liver.With the exception of lycopene, the treatments had some effect on the activity of one or more hepatic phase II detoxification enzymes. We conclude that PEITC and chlorophyllin are protective of PhIP-induced genotoxicity after a low exposure dose of carcinogen, possibly through modification of HCA metabolism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENS
KW - GENETIC toxicology
KW - HETEROCYCLIC compounds
KW - AMINES
N1 - Accession Number: 11650172; Dingley, Karen H. 1 Ubick, Esther A. 1 Chiarappa-Zucca, Marina L. 2 Nowell, Susan 3 Abel, Steffen 4 Ebeler, Susan E. 5 Mitchell, Alyson E. 6 Burns, Stephanie A. Steinberg, Francene M. Clifford, Andrew J. 7; Affiliation: 1: Biology and Biotechnology Research Program and Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory 2: Chemical Biology and Nuclear Division, Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory 3: National Center for Toxicological Research, AR 4: Department of Vegetable Crops, University of California, Davis, CA 5: Department of Viticulture and Enology, University of California, Davis, CA 6: Department of Food Science and Technology, and University of California, Davis, CA 7: Department of Nutrition, University of California, Davis, CA; Source Info: 2003, Vol. 46 Issue 2, p212; Subject Term: CARCINOGENS; Subject Term: GENETIC toxicology; Subject Term: HETEROCYCLIC compounds; Subject Term: AMINES; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106705879
T1 - The pediatric tympanic membrane: see it, describe it, treat it.
AU - McDivitt K
Y1 - 2003///2003 Summer
N1 - Accession Number: 106705879. Language: English. Entry Date: 20040227. Revision Date: 20150820. Publication Type: Journal Article; glossary; pictorial; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9206573.
KW - Otitis Media -- Diagnosis -- In Infancy and Childhood
KW - Diagnosis, Ear -- In Infancy and Childhood
KW - Tympanic Membrane -- In Infancy and Childhood
KW - Child
KW - Acute Disease
KW - Otorhinolaryngology and Head-Neck Nursing
KW - Child, Preschool
KW - Color
KW - Otitis Media -- Drug Therapy
KW - Antibiotics -- Therapeutic Use
KW - Practice Guidelines
SP - 14
EP - 17
JO - ORL-Head & Neck Nursing
JF - ORL-Head & Neck Nursing
JA - ORL HEAD NECK NURS
VL - 21
IS - 3
CY - New Smyrna Beach, Florida
PB - Society of Otorhinolaryngology & Head-Neck Nurses
AB - Acute otitis media (AOM) is one of the most common childhood conditions for which antibiotics are prescribed, often unnecessarily. Current medical literature focuses on the treatment of AOM, appropriate antibiotics, and antibiotic resistance. Placing more emphasis on examination and description of the tympanic membrane (TM) reduces the over-diagnosing of AOM and concerns associated with antibiotic use. A thorough examination of the ear must be performed in order to make an accurate diagnosis. This article presents a three-step technique to assist providers to perform pneumatic otoscopy, visualize the TM, describe their findings, and subsequently treat AOM.
SN - 1064-3842
AD - ENT Nurse Practitioner, Indian Health Service, Blackfeet Indiana Reservation, Montana; keith.mcdivitt@mail.ihs.gov
U2 - PMID: 12961791.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106624109
T1 - International environmental health for the pediatrician: case study of lead poisoning.
AU - Falk H
Y1 - 2003/07//
N1 - Accession Number: 106624109. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; case study; pictorial; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Environmental Health
KW - Environmental Pollutants
KW - Lead Poisoning -- Risk Factors
KW - Child
KW - Developing Countries
KW - India
KW - Lead -- Blood
KW - Paint
SP - 259
EP - 264
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 112
IS - 1
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - Childhood lead poisoning is a preventable illness. In the past 3 decades, removal of key lead sources and prevention of exposure in the United States have led to dramatic decreases in population blood lead concentrations and also in instances of severe lead poisoning requiring treatment. From an international perspective, childhood lead poisoning seems to be of greatest concern in developing countries. The phasing out of lead from gasoline is a critical first step in decreasing worldwide blood lead concentrations. However, many focal sources that can cause lead poisoning remain, such as lead from flour mills, lead-glazed ceramics, mining and smelting, and battery repair and recycling. A large and diverse country, such as India, may have many sources of lead. The challenge will be for developing countries to implement effective national and regional efforts to address their specific sources of lead.
SN - 0031-4005
AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA 30341; hxf1@cdc.gov
U2 - PMID: 12837919.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106653910
T1 - Introduction: consequences of terrorism.
AU - Noji EK
Y1 - 2003/07//2003 Jul-Sep
N1 - Accession Number: 106653910. Language: English. Entry Date: 20041022. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8918173.
KW - Disaster Planning
KW - Terrorism
KW - China
KW - Severe Acute Respiratory Syndrome -- China
SP - 163
EP - 164
JO - Prehospital & Disaster Medicine
JF - Prehospital & Disaster Medicine
JA - PREHOSPITAL DISASTER MED
VL - 18
IS - 3
PB - Cambridge University Press
AB - Recent acts of terrorism have ranged from the dissemination of anthrax spores to intentional contamination of food to the release of chemical weapons to suicide attacks using explosives. The prediction of such events is difficult, if not impossible. The recent attacks that have generated massive numbers of injured and dead may signal the crossing of a new threshold from multi-casualty events to the use of weapons of mass destruction. Consequently, the medical and healthcare infrastructure must be able to prevent and treat illness and injury resulting from such events. Thus, a first step in improving the preparation for and responses to such events must include a sustained commitment to training physicians, nurses, identification specialists, pathologists, and other first responders. The rapid spread of SARS gives reason to believe that the distribution of such agents has potential advantages over the use of other weapons. Investments in the public health and healthcare systems provide the best defense against terrorism.
SN - 1049-023X
AD - Special Assistant to the US Surgeon General for Homeland Security, US Public Health Service, Washington DC; exn1@cdc.gov
U2 - PMID: 15141852.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106653910&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106653919
T1 - Public health response actions and the use of emergency operations centers.
AU - Mignone AT Jr.
AU - Davidson R
Y1 - 2003/07//2003 Jul-Sep
N1 - Accession Number: 106653919. Language: English. Entry Date: 20041022. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8918173.
KW - Disaster Planning
KW - Public Health
KW - Terrorism
KW - Communication
KW - United States
SP - 217
EP - 219
JO - Prehospital & Disaster Medicine
JF - Prehospital & Disaster Medicine
JA - PREHOSPITAL DISASTER MED
VL - 18
IS - 3
PB - Cambridge University Press
AB - In the wake of 11 September 2001, many public health agencies are reassessing their institutional capabilities and procedures to respond to mass-casualty incidents involving weapons of mass destruction. Prior to the fall of 2001, planning by the public health and other sectors addressed more conventional or naturally occurring events such as earthquakes, hurricanes, tornados, and chemical spills, although attacks with weapons of mass destruction were a growing concern. While the nature of natural versus intentional events differs, the management and coordination of response activities to them follows the same incident command system. A major lesson learned during the response operations to the 11 September 2001 attacks in New York City was the value of disaster planning, conducting exercises, and developing relationships among the various response agencies. Although New York City's physical Emergency Operations Center (EOC) at 7 World Trade Center was destroyed in the attack, the medical and health response community was able to react effectively to the possibility of mass casualties as well as to the more usual needs. This was enabled by the pre-existing relationships that had been developed between city, state, federal, and non-governmental agencies while planning and exercising for such events and their aftermaths.
SN - 1049-023X
AD - US Public Health Service, New York, NY
U2 - PMID: 15141861.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Repique, C. J.
AU - Li, A.
AU - Brickey, W. J.
AU - Ting, J. P. Y.
AU - Collins, F. M.
AU - Morris, S. L.
T1 - Susceptibility of Mice Deficient in the MHC Class II Transactivator to Infection with Mycobacterium tuberculosis.
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
Y1 - 2003/07//
VL - 58
IS - 1
M3 - Article
SP - 15
EP - 22
PB - Wiley-Blackwell
SN - 03009475
AB - Abstract Major histocompatibility complex (MHC) class II antigen presentation and subsequent CD4+ T-cell activation are critical for acquired immunity to Mycobacterium tuberculosis infection. MHC class II gene expression is primarily controlled by the master transactivator CIITA protein. Without functional CIITA protein, MHC class II expression is lost, impairing immune responses and increasing susceptibility to infection. In this study, we compared protective immune responses of CIITA-deficient mice and wild-type C57BL/6 controls with low dose aerosol M. tuberculosis infection. After aerogenic challenge, CIITA–/– mice failed to limit mycobacterial growth (2.5 and 2.0 log10 > WT lung and spleen CFUs, respectively, at day 58). Lung histopathology involved extensive necrosis, severe pneumonitis and overwhelming inflammation in the gene knockout mice. Mean survival time for CIITA–/– mice was significantly reduced (57 versus >300 days for WT). This extreme sensitivity to tuberculous infection was largely attributed to the absence of CD4+ cells. Flow cytometric studies detected virtually no CD4+ cells in CIITA–/– mouse spleens after infection versus elevated numbers in WT spleens. Failed CD4+ T-cell expansion markedly reduced interferon-γ (IFN-γ production in CIITA–/– mice versus WT controls. These results suggest the necessity of a functional CIITA pathway for controlling tuberculous infections and that interventions targeting CIITA expression may be useful antimycobacterial therapeutics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIAL diseases
KW - LUNG diseases
KW - TUBERCULOSIS
KW - IMMUNITY
KW - INTERFERONS
N1 - Accession Number: 10130489; Repique, C. J. 1 Li, A. 1 Brickey, W. J. 2 Ting, J. P. Y. 2 Collins, F. M. 1 Morris, S. L. 1; Affiliation: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD; and 2: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Source Info: Jul2003, Vol. 58 Issue 1, p15; Subject Term: MYCOBACTERIAL diseases; Subject Term: LUNG diseases; Subject Term: TUBERCULOSIS; Subject Term: IMMUNITY; Subject Term: INTERFERONS; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1365-3083.2003.01266.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vaidya, Vishal S.
AU - Shankar, Kartik
AU - Lock, Edward A.
AU - Bucci, Thomas J.
AU - Mehendale, Harihara M.
T1 - Role of Tissue Repair in Survival from S-(1,2-Dichlorovinyl)-L-Cysteine-Induced Acute Renal Tubular Necrosis in the Mouse.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/07//
VL - 74
IS - 1
M3 - Article
SP - 215
EP - 227
PB - Oxford University Press / USA
SN - 10966080
AB - S-(1,2-Dichlorovinyl)-L-cysteine (DCVC), a model nephrotoxicant in mice, causes acute tubular necrosis and death at high doses. Our earlier studies revealed that renal tissue repair was critical for survival in mice with DCVC nephrotoxicity. The objective of this study was to investigate if increasing renal tissue repair could protect mice from the lethal outcome of DCVC. Male Swiss Webster (SW) mice were administered a low dose of DCVC (15 mg/kg, ip) 72 h before injection of a normally lethal dose of DCVC (75 mg/kg, ip); this resulted in 100% protection against the lethal effect of DCVC. Because DCVC caused ~twofold decrease in cytosolic and mitochondrial β-lyase activity, the possibility that DCVC protection may be caused by decreased bioactivation was examined. Mercuric chloride (HgCl2, 6 mg/kg), a nephrotoxicant with no effect on β-lyase activity, was administered 96 h before a lethal dose of DCVC. This also resulted in 100% protection from the lethal effect of DCVC. In both studies total glutathione was unchanged at any time after the lethal dose of DCVC was administered, obviating the role of glutathione in protection. In both cases the augmented and sustained tissue repair induced by priming dose and documented by 3H-thymidine pulse labeling and immunocytochemistry for proliferating cell nuclear antigen resulted in 100% survival in spite of the extensive renal injury. These findings suggest that stimulation of renal tubular repair by the priming dose, through augmented cell division, and the resistance of new cells to mechanisms of progression of injury, underlies auto- and heteroprotection against DCVC. The molecular mechanisms may have potential application in pharmacotherapeutic intervention for treatment of acute renal failure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mercuric chloride
KW - RESEARCH
KW - Kidney diseases
KW - Necrosis
KW - Nephrotoxicology
KW - Glutathione
KW - Immunocytochemistry
KW - Toxicology
KW - Mice as laboratory animals
KW - β-lyase
KW - DCVC
KW - mercuric chloride
KW - protection
KW - renal injury
KW - tissue repair
N1 - Accession Number: 20606181; Vaidya, Vishal S. 1; Shankar, Kartik 1; Lock, Edward A. 2; Bucci, Thomas J. 3; Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliations: 1: Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Sugar Hall, Room 306, Monroe, Louisiana 71209-0470; 2: Syngenta, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK 104TJ, United Kingdom; 3: Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas 72079; Issue Info: Jul2003, Vol. 74 Issue 1, p215; Thesaurus Term: Mercuric chloride; Thesaurus Term: RESEARCH; Subject Term: Kidney diseases; Subject Term: Necrosis; Subject Term: Nephrotoxicology; Subject Term: Glutathione; Subject Term: Immunocytochemistry; Subject Term: Toxicology; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: β-lyase; Author-Supplied Keyword: DCVC; Author-Supplied Keyword: mercuric chloride; Author-Supplied Keyword: protection; Author-Supplied Keyword: renal injury; Author-Supplied Keyword: tissue repair; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
L3 - 10.1093/toxsci/kfg111
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Hastings, Kenneth L.
AU - El-Hage, Jeri
AU - Jacobs, Abigail
AU - Leighton, John
AU - Morse, David
AU - Osterberg, Robert E.
T1 - Letter to the Editor
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2003/07//
VL - 190
IS - 1
M3 - Letter
SP - 91
SN - 0041008X
N1 - Accession Number: 10064415; Hastings, Kenneth L. 1; Email Address: hastings@cder.fda.gov; El-Hage, Jeri 1; Jacobs, Abigail 1; Leighton, John 1; Morse, David 1; Osterberg, Robert E. 1; Affiliations: 1: Office of New Drugs, Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, MD 20857, USA; Issue Info: Jul2003, Vol. 190 Issue 1, p91; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/S0041-008X(03)00150-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bird, Chloe E.
AU - Fremont, Allen
AU - Wickstrom, Steven
AU - Bierman, Arlene S.
AU - McGlynn, Elizabeth
T1 - Improving women’s quality of care for cardiovascular disease and diabetes: the feasibility and desirability of stratified reporting of objective performance measures
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2003/07//
VL - 13
IS - 4
M3 - Article
SP - 150
SN - 10493867
AB - Despite growing recognition of significant morbidity and mortality among women from cardiovascular disease, management of primary and secondary cardiac risk factors continues to be suboptimal for many women. Although there is a good deal of room to improve the care for cardiovascular disease and diabetes in men, existing gender differences in performance suggest much can be gained by specifically assessing and monitoring quality of care for these conditions in women. In this paper, we describe recent work showing gender differences in quality of ambulatory care in managed care plans with some plans having substantial gender differences on widely used measures of the quality of primary and secondary prevention of cardiac disease. We then discuss potential benefits of and barriers to routine reporting of objective measures of the quality of care, such as Health Plan Employer Data and Information Set (HEDIS) measures, by health plans. [Copyright &y& Elsevier]
AB - Copyright of Women's Health Issues is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR diseases
KW - WOMEN -- Diseases
KW - MORTALITY
KW - PRIMARY health care
KW - Cardiovascular disease
KW - Gender
KW - Hedis
KW - Managed care
KW - Primary care
KW - Quality of care
N1 - Accession Number: 10806851; Bird, Chloe E. 1; Email Address: Chloe_Bird@rand.org Fremont, Allen 1 Wickstrom, Steven 2 Bierman, Arlene S. 3 McGlynn, Elizabeth 1; Affiliation: 1: RAND, Santa Monica, California, USA 2: Center for Health Care Policy and Evaluation, UnitedHealth Group, Eden Prairie, MN, USA 3: Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, USA; Source Info: Jul2003, Vol. 13 Issue 4, p150; Subject Term: CARDIOVASCULAR diseases; Subject Term: WOMEN -- Diseases; Subject Term: MORTALITY; Subject Term: PRIMARY health care; Author-Supplied Keyword: Cardiovascular disease; Author-Supplied Keyword: Gender; Author-Supplied Keyword: Hedis; Author-Supplied Keyword: Managed care; Author-Supplied Keyword: Primary care; Author-Supplied Keyword: Quality of care; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S1049-3867(03)00035-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10806851&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldenhar, Linda M.
AU - Williams, Larry J.
AU - Swanson, Naomi G.
T1 - Modelling relationships between job stressors and injury and near-miss outcomes for construction labourers.
JO - Work & Stress
JF - Work & Stress
Y1 - 2003/07//
VL - 17
IS - 3
M3 - Article
SP - 218
EP - 240
PB - Taylor & Francis Ltd
SN - 02678373
AB - Construction work is an inherently dangerous occupation and exposure to additional job stressors is likely to exacerbate the level of danger, increasing workers' risk for injury. Thus, it is important to identify and then reduce worker exposure to extraneous job stressors. This study examines the relationships between a variety of job stressors and injury or near-miss outcomes among construction workers. Self-reported questionnaire data collected from 408 construction labourers (male and female) via telephone interview were analysed using structural equation modelling. A theoretical model was tested whereby work stressors, classified into three groups, could be related, either directly or indirectly through the mediating effects of physical or psychological symptoms/strain, to self-reported injuries and near misses. Ten of the 12 work-related stressors were found to be directly related to either injury or near misses, including: job demands, job control, job certainty, training, safety climate, skill under-utilization, responsibility for the safety of others, safety compliance, exposure hours, and job tenure. Other stressors (i.e. harassment/discrimination, job certainty, social support, skill under-utilization, safety responsibility, safety compliance, tenure in construction) were indirectly related to injuries through physical symptoms or indirectly related to near misses through psychological strain. There was no support for the modelled gender differences. Implications for health and safety on construction sites are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Work & Stress is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LABOR
KW - QUESTIONNAIRES
KW - ACCIDENTS
KW - SYMPTOMS
KW - Construction
KW - Injuries
KW - Job stressors
KW - Structural Equation Modelling
N1 - Accession Number: 11623003; Goldenhar, Linda M. 1; Email Address: Linda. Goldenhar@uc.edu Williams, Larry J. 2 Swanson, Naomi G. 3; Affiliation: 1: Institute for Health Policy and Health Services Research, University of Cincinnati Medical Center, P0 Box 670840, Cincinnati, OH 45267-0840, USA. 2: Department of Management, Virginia Commonwealth University, P0 Box 844000, Richmond, VA 23284, USA. 3: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway MS-C24, Cincinnati, OH 45226, USA.; Source Info: Jul2003, Vol. 17 Issue 3, p218; Subject Term: LABOR; Subject Term: QUESTIONNAIRES; Subject Term: ACCIDENTS; Subject Term: SYMPTOMS; Author-Supplied Keyword: Construction; Author-Supplied Keyword: Injuries; Author-Supplied Keyword: Job stressors; Author-Supplied Keyword: Structural Equation Modelling; Number of Pages: 23p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1080/02678370310001616144
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11623003&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106738542
T1 - Modelling relationships between job stressors and injury and near-miss outcomes for construction labourers.
AU - Goldenhar LM
AU - Williams LJ
AU - Swanson NG
Y1 - 2003/07//
N1 - Accession Number: 106738542. Language: English. Entry Date: 20040528. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: National Institute for Occupational Safety and Health (NIOSH) Job Stress Questionnaire (Hurrell and McLaney). NLM UID: 8707605.
KW - Construction Industry
KW - Occupational Exposure -- Prevention and Control
KW - Occupational-Related Injuries
KW - Stress, Occupational
KW - Chi Square Test
KW - Coefficient Alpha
KW - Descriptive Statistics
KW - Discriminant Validity
KW - Discrimination, Employment
KW - Factor Analysis
KW - Female
KW - Interviews
KW - Job Experience
KW - Job Security
KW - LISREL
KW - Male
KW - Models, Theoretical
KW - Northwestern United States
KW - Occupational Hazards
KW - Occupational Safety
KW - P-Value
KW - Questionnaires
KW - Self Report
KW - Sex Factors
KW - Sexual Harassment
KW - Structural Equation Modeling
KW - Summated Rating Scaling
KW - Support, Psychosocial
KW - Human
SP - 218
EP - 240
JO - Work & Stress
JF - Work & Stress
JA - WORK STRESS
VL - 17
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Construction work is an inherently dangerous occupation and exposure to additional job stressors is likely to exacerbate the level of danger, increasing workers' risk for injury. Thus, it is important to identify and then reduce worker exposure to extraneous job stressors. This study examines the relationships between a variety of job stressors and injury or near-miss outcomes among construction workers. Self-reported questionnaire data collected from 408 construction labourers (male and female) via telephone interview were analysed using structural equation modelling. A theoretical model was tested whereby work stressors, classified into three groups, could be related, either directly or indirectly through the mediating effects of physical or psychological symptoms/strain, to self-reported injuries and near misses. Ten of the 12 work-related stressors were found to be directly related to either injury or near misses, including: job demands, job control, job certainty, training, safety climate, skill under-utilization, responsibility for the safety of others, safety compliance, exposure hours, and job tenure. Other stressors (i.e. harassment/discrimination, job certainty, social support, skill under-utilization, safety responsibility, safety compliance, tenure in construction) were indirectly related to injuries through physical symptoms or indirectly related to near misses through psychological strain. There was no support for the modelled gender differences. Implications for health and safety on construction sites are discussed.
SN - 0267-8373
AD - Research Psychologist at the National Institute for Occupational Safety and Health; Linda.Goldenhar@uc.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chapman, Louisa E.
AU - Wilson, Carolyn A.
T1 - Implications of the advent of homozygous α l, 3-galactosyltransferase gene-deficient pigs on transmission of infectious agents.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2003/07//
VL - 10
IS - 4
M3 - Article
SP - 287
EP - 288
PB - Wiley-Blackwell
SN - 0908665X
AB - Focuses on implications of the advent of homozygous α 1, 3-galactosyltransferase gene-deficient pigs on transmission of infection during xenografting. Reason for removing alpha-galactosyl residue for transplantation; Effect of complement-mediated destruction by lysis on transplanted tissues; Impact of changes in lipid membrane of the host cell on on outer envelop of viruses.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - GALACTOSYLTRANSFERASES
KW - SWINE
KW - LIPID membranes
KW - VIRUS diseases
N1 - Accession Number: 9988018; Chapman, Louisa E. 1 Wilson, Carolyn A.; Affiliation: 1: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E-mail: lec3@cdc.gov) Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland (E-mail: wilsonc@cber.fda.gov); Source Info: Jul2003, Vol. 10 Issue 4, p287; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: GALACTOSYLTRANSFERASES; Subject Term: SWINE; Subject Term: LIPID membranes; Subject Term: VIRUS diseases; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
L3 - 10.1034/j.1399-3089.2003.00074.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McIntyre, Matiza C.
AU - Kannan, Bhanumathi
AU - Solano-Aguilar, Gloria I.
AU - Wilson, Carolyn A.
AU - Bloom, Eda T.
T1 - Detection of porcine endogenous retrovirus in cultures of freshly isolated porcine bone marrow cells.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2003/07//
VL - 10
IS - 4
M3 - Article
SP - 337
EP - 342
PB - Wiley-Blackwell
SN - 0908665X
AB - Abstract: Pigs are under consideration as possible sources of organs for xenotransplantation in humans. The induction of hematopoietic microchimerism through xenotransplantation of source animal hematopoietic cells has been suggested as a means to induce tolerance in potential recipients. Because all porcine cells contain genetic information for porcine endogenous retrovirus (PERV), coculture techniques, reverse transcriptase (RT) and reverse transcriptase-polymerase chain reaction assays were used to determine whether infectious PERV is released from fresh porcine bone marrow cells cultured in the presence or absence of porcine cytokines. Human embryonic kidney cell line, HEK-293 cells cocultured with porcine bone marrow cells were positive for PERV RNA but never became positive for viral RT activity, suggesting the PERV infection was not productive. In contrast, high levels of RT activity was detected in porcine ST-IOWA cells after coculture, demonstrating that these cells became productively infected. PERV was released from cultured porcine bone marrow cells without stimulation, and combinations of the porcine hematopoietic cytokines, interleukin-3, granulocyte macrophage-colony stimulating factor and stem cell factor had no additional effect on the infectivity or in vitro tropism of released PERV virions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenotransplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETROVIRUSES
KW - BONE marrow
KW - TRANSPLANTATION of organs, tissues, etc.
KW - SWINE
KW - PORCINE somatotropin
KW - bone marrow
KW - human
KW - pig
KW - retrovirus
KW - xenotransplantation
N1 - Accession Number: 9988011; McIntyre, Matiza C. 1 Kannan, Bhanumathi 2 Solano-Aguilar, Gloria I. 3 Wilson, Carolyn A. 1 Bloom, Eda T. 1; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, MD, USA, 2: Division of Inspections and Surveillance, CBER, FDA, Rockville, MD, USA, and 3: Nutrient and Function Requirement Laboratory, Beltsville Human Nutrition Research Institute, USDA, Agricultural Research Service, Beltsville, MD, USA; Source Info: Jul2003, Vol. 10 Issue 4, p337; Subject Term: RETROVIRUSES; Subject Term: BONE marrow; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: SWINE; Subject Term: PORCINE somatotropin; Author-Supplied Keyword: bone marrow; Author-Supplied Keyword: human; Author-Supplied Keyword: pig; Author-Supplied Keyword: retrovirus; Author-Supplied Keyword: xenotransplantation; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1034/j.1399-3089.2003.02044.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=9988011&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2003-08951-002
AN - 2003-08951-002
AU - Goldklang, Stephen
AU - Rusinko, William
AU - Luongo, Peter F.
AU - Arria, Amelia M.
AU - Hsu, Maggie
AU - Lee, Aimee
AU - Petronis, Ken
AU - Rosenberg, Marsha
AU - Wish, Eric
AU - Davis, Steve
AU - Leeper, Tracy
AU - Moore, Rebecca
AU - Close, Melissa
AU - Krupski, Antoinette
AU - Longhi, Dario
AU - He, Lijian
AU - Amos, Daniel
AU - Luchansky, Bill
AU - Krause, Hal
T1 - Drug treatment completion and post-discharge employment in the TOPPS-II Interstate Cooperative Study.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2003/07//
VL - 25
IS - 1
SP - 9
EP - 18
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Arria, Amelia M., Center for Substance Abuse Research (CESAR), 4321 Hartwick Road, Suite 501, College Park, MD, US, 20745
N1 - Accession Number: 2003-08951-002. Partial author list: First Author & Affiliation: Goldklang, Stephen; Maryland Alcohol and Drug Abuse Administration, Catonsville, MD, US. Institutional Authors: The TOPPS-II Interstate Cooperative Study Group. Release Date: 20031103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Employment Status; Job Search; Salaries; Treatment Duration. Minor Descriptor: Public Sector; Regional Differences; Treatment Termination. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2003.
AB - Examined the effect of drug treatment completion on patients' subsequent employment and wages earned in the year following discharge, and compared the consistency of these results across 3 states. Drug treatment and wage data from 20,495 drug treatment patients were used. Treatment data were provided by the state substance abuse management information systems for Baltimore City, Washington State, and Oklahoma. Wage data were provided by the states' agency responsible for collecting and reporting wage information. A quasi-experimental design was used to compare treatment completers and non-completers in the year after an index treatment episode. Employment history in the year prior to the index episode was used to statistically adjust for group differences. The index episode of care may have included services under more than one treatment modality. The full social security number was used to link the drug treatment and wage administrative datasets. Treatment completers were 22-49% more likely than non-completers to be employed and to earn higher wages in the year following treatment, holding other variables constant. Patients staying in treatment longer than 90 days were 22-43% more likely to be employed in the year following treatment than those who stayed a shorter time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug treatment completion
KW - post discharge employment
KW - wages
KW - substance abuse
KW - state substance abuse management information systems
KW - 2003
KW - Drug Rehabilitation
KW - Employment Status
KW - Job Search
KW - Salaries
KW - Treatment Duration
KW - Public Sector
KW - Regional Differences
KW - Treatment Termination
KW - 2003
DO - 10.1016/S0740-5472(03)00050-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-08951-002&site=ehost-live&scope=site
UR - aarria@cesar.umd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-05268-001
AN - 2005-05268-001
AU - Berg, Alfred O.
T1 - Behavioral Interventions to Promote Breastfeeding: Recommendations and Rationale.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2003/07//Jul-Aug, 2003
VL - 1
IS - 2
SP - 79
EP - 80
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Berg, Alfred O., USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD, US, 20850
N1 - Accession Number: 2005-05268-001. Partial author list: First Author & Affiliation: Berg, Alfred O.; Department of Family Medicine, University of Washington, Seattle, WA, US. Institutional Authors: U.S. Preventive Services Task Force. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Counseling; Health Education; Health Promotion. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul-Aug, 2003.
AB - The US Preventive Services Task Force (USPSTF) recommends structured breastfeeding education and behavioral counseling programs to promote breastfeeding. The USPSTF found fair evidence that programs combining breastfeeding education with behaviorally-oriented counseling are associated with increased rates of breastfeeding initiation and its continuation for up to 3 months, although effects beyond 3 months are uncertain. The USPSTF found fair evidence that providing ongoing support for patients, through in-person visits or telephone contacts with providers or counselors, increased the proportion of women continuing breastfeeding for up to 6 months. Such support, however, had a much smaller effect than educational programs on the initiation of breastfeeding and its continuation for up to 3 months. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral interventions
KW - breastfeeding education
KW - recommendations
KW - US Preventive Services Task Force
KW - 2003
KW - Breast Feeding
KW - Counseling
KW - Health Education
KW - Health Promotion
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05268-001&site=ehost-live&scope=site
UR - uspstf@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05792-003
AN - 2003-05792-003
AU - Chelonis, John J.
AU - Gillam, Michael P.
AU - Paule, Merle G.
T1 - The effects of prenatal cocaine exposure on reversal learning using a simple visual discrimination task in rhesus monkeys.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2003/07//Jul-Aug, 2003
VL - 25
IS - 4
SP - 437
EP - 446
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Chelonis, John J., Department of Psychology, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR, US, 72204
N1 - Accession Number: 2003-05792-003. PMID: 12798961 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Chelonis, John J.; Department of Psychology, University of Arkansas at Little Rock, Little Rock, AR, US. Release Date: 20030908. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Drug Dosages; Prenatal Exposure; Reversal Shift Learning; Visual Discrimination. Minor Descriptor: Monkeys. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul-Aug, 2003.
AB - Determined if adult animals that were exposed to cocaine prenatally would be able to adapt to changes in the rules of reinforcement for a simple discrimination task. Ss were 11 monkeys. Treatment groups included 0.0, 1.0, and 3.0 mg cocaine/kg/day and an escalating-dose group that began treatment at 3.0 mg cocaine/kg/day, after which the dose was increased by 0.5 mg cocaine/kg/day every 2 weeks throughout the pregnancy. All animals performed a color and position discrimination task for food reinforcers for approximately 6 years before the present study. For this task, subjects were presented with colored stimuli that determined the correctness of subsequent position choices: left for red or yellow and right for blue or green. At 7 years of age, the rules for obtaining reinforcement were reversed. Animals exposed to all doses of cocaine showed impaired reversal performance. Further, animals exposed to the escalating doses of cocaine continued to show this impairment for over 285 sessions (about 2 1/2 years). The number of sessions required by subjects to master these contingency changes indicated that, using a task with which they have an extensive history, cocaine-exposed animals have greater difficulty in adapting to important changes in their environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prenatal exposure
KW - cocaine
KW - reversal learning
KW - visual discrimination task
KW - adult monkeys
KW - drug dosage
KW - 2003
KW - Cocaine
KW - Drug Dosages
KW - Prenatal Exposure
KW - Reversal Shift Learning
KW - Visual Discrimination
KW - Monkeys
KW - 2003
DO - 10.1016/S0892-0362(03)00017-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05792-003&site=ehost-live&scope=site
UR - jjchelonis@ualr.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99826-010
AN - 2003-99826-010
AU - Hennessy, Kevin D.
AU - Green-Hennessy, Sharon
AU - Buck, Jeffrey A.
AU - Miller, Kay
T1 - Psychotropic Drug Use and Expenditures Among Medicaid Beneficiaries With and Without Other Mental Health or Substance Abuse Services.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 2003/07//
VL - 191
IS - 7
SP - 476
EP - 478
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Hennessy, Kevin D., Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, 200 Independence Ave, SW Room 442E, Washington, DC, US, 20201
N1 - Accession Number: 2003-99826-010. PMID: 12891096 Partial author list: First Author & Affiliation: Hennessy, Kevin D.; US Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation, Washington, DC, US. Release Date: 20030929. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Health Care Costs; Health Care Utilization; Medicaid; Mental Disorders. Minor Descriptor: Drug Abuse; Mental Health; Mental Health Services; Prescription Drugs. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study. References Available: Y. Page Count: 3. Issue Publication Date: Jul, 2003.
AB - Over the past 2 decades, dramatic increases in both the utilization and cost of prescription drugs have contributed disproportionately to rising US health care expenditures. This trend has been particularly evident in mental health, where the introduction of new psychiatric medications has dramatically improved the treatment of various mental disorders while concurrently contributing to increased spending for mental health services. In an effort to better understand factors that may relate to these trends, this study provides descriptive data on psychotropic drug use and expenditures within 10 state Medicaid programs in 1995. Because recent research highlights the value of combining pharmacological and psychosocial treatment for mental disorders, a particular focus of this study is identifying the extent to which psychotropic medications are used in isolation versus used with other mental health or substance abuse services or both. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care expenditures
KW - psychotropic medications
KW - substance abuse services
KW - psychiatric medications
KW - mental health services
KW - psychosocial treatment
KW - prescription drugs
KW - 2003
KW - Drug Therapy
KW - Health Care Costs
KW - Health Care Utilization
KW - Medicaid
KW - Mental Disorders
KW - Drug Abuse
KW - Mental Health
KW - Mental Health Services
KW - Prescription Drugs
KW - 2003
DO - 10.1097/01.NMD.0000081618.48185.DB
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99826-010&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3484-2663
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05792-007
AN - 2003-05792-007
AU - MacPhail, R. C.
AU - O'Callaghan, J. P.
AU - Cohn, J.
T1 - Acquisition, steady-state performance, and the effects of trimethyltin on the operant behavior and hippocampal GFAP of Long--Evans and Fischer 344 rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2003/07//Jul-Aug, 2003
VL - 25
IS - 4
SP - 481
EP - 490
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - O'Callaghan, J. P., TMBB/HELD, CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, US, 26508
N1 - Accession Number: 2003-05792-007. PMID: 12798965 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: MacPhail, R. C.; Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, US. Release Date: 20030908. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Strain Differences; Hippocampus; Neurotoxins; Operant Conditioning; Proteins. Minor Descriptor: Animal Ethology; Rats; Reinforcement Schedules. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul-Aug, 2003.
AB - Compared the schedule-controlled operant behavior of adult male Long-Evans (LE) and Fischer 344 (F344) rats (n=12 each) by assessing acquisition of performance (AP), steady-state performance (SSP; baseline); and the effects of trimethyltin (TMT). Hippocampal Glial fibrillary acidic protein (GFAP) levels were determined as an index of the degree of TMT-induced damage to this structure. Ss were put in operant chambers and trained to respond under a multiple, fixed-interval (FI) 3-min fixed-ratio 10-response schedule of milk reinforcement. AP was characterized by time-dependent changes in behavioral endpoints in both strains, although the AP rate of the FI pattern of responding was slower in F344 rats. SSP was characterized by slower rates of responding in F344 rats. There was little evidence of strain differences in many of the other baseline performance measures. Ss of each strain were then divided into 2 equal groups that received either 1 ml/kg saline or 8.0 mg/kg iv TMT. TMT produced transient changes in the performance of LE and F344 rats that lasted for several sessions. For many behavioral measures, F344 rats were more affected by TMT. TMT-induced reactive gliosis was also greater in F344 rats. Results suggest F344 rats may be more susceptible to TMT induced neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - acquisition
KW - steady-state performance
KW - trimethyltin
KW - operant behavior
KW - schedule controlled behavior
KW - hippocampus
KW - Glial fibrillary acidic protein
KW - Long-Evans rats
KW - Fischer 344 rats
KW - strain differences
KW - 2003
KW - Animal Strain Differences
KW - Hippocampus
KW - Neurotoxins
KW - Operant Conditioning
KW - Proteins
KW - Animal Ethology
KW - Rats
KW - Reinforcement Schedules
KW - 2003
DO - 10.1016/S0892-0362(03)00012-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05792-007&site=ehost-live&scope=site
UR - jdo5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05792-008
AN - 2003-05792-008
AU - Ferguson, Sherry A.
AU - Delclos, K. Barry
AU - Newbold, Retha R.
AU - Flynn, Katherine M.
T1 - Dietary ethinyl estradiol exposure during development causes increased voluntary sodium intake and mild maternal and offspring toxicity in rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2003/07//Jul-Aug, 2003
VL - 25
IS - 4
SP - 491
EP - 501
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
N1 - Accession Number: 2003-05792-008. PMID: 12798966 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; HFT-132/Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, US. Release Date: 20030908. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Development; Animal Feeding Behavior; Animal Sex Differences; Animal Sexual Behavior; Estradiol. Minor Descriptor: Body Weight; Diets; Food Intake; Prenatal Exposure; Rats; Weaning. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul-Aug, 2003.
AB - Examined the effects of dietary ethinyl estradiol (EE₂) exposure during development. Pregnant Sprague-Dawley rats consumed diets containing 0, 1, 5 or 200 ppb EE₂ beginning on gestational day 7. Offspring (OS) were weaned to the same maternal diet and maintained gonadally intact. In addition to body weight (BW), food intake (FI), and nursing behavior (NB), 4 sexually dimorphic behaviors (SDBs) were assessed in male and female OS: open-field activity (OFA), running wheel activity (RWA), juvenile play behavior (JPB) and intake of sodium chloride- and saccharine-flavored solutions (FSs). There were mild effects on BW and FI in dams of the 200 ppb group and their OS weighed less at birth than controls; however, gross assessments of NB were normal in all dietary groups. Postweaning, 200 ppb OS weighed less and consumed less food than controls. There were no EE₂-related effects on OFA, JPB, RWA or intake of a 0.3% saccharin-FS. Intake of a 3.0% sodium chloride-FS was increased in both male and female OS of the 200 ppb group relative to same-sex controls. While EE₂ exposure had few effects on the conventional tests of SDBs, exposure to 200 ppb in the diet appeared to feminize females and hyperfeminize males with regard to sodium intake. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethinyl estradiol
KW - gestational exposure
KW - weaning
KW - dietary exposure
KW - body weight
KW - food intake
KW - nursing behavior
KW - sexually dimorphic behaviors
KW - animal sex differences
KW - rats
KW - animal devleopment
KW - 2003
KW - Animal Development
KW - Animal Feeding Behavior
KW - Animal Sex Differences
KW - Animal Sexual Behavior
KW - Estradiol
KW - Body Weight
KW - Diets
KW - Food Intake
KW - Prenatal Exposure
KW - Rats
KW - Weaning
KW - 2003
DO - 10.1016/S0892-0362(03)00015-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05792-008&site=ehost-live&scope=site
UR - sferguson@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-07261-002
AN - 2003-07261-002
AU - Davis, Maryann
T1 - Addressing the needs of youth in transition to adulthood.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2003/07//
VL - 30
IS - 6
SP - 495
EP - 509
CY - Germany
PB - Springer
SN - 0894-587X
AD - Davis, Maryann, Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, MA, US, 01655
N1 - Accession Number: 2003-07261-002. PMID: 13677456 Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20030915. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Emotional Disturbances; Mental Health; Needs; Public Health Services. Minor Descriptor: Childhood Development. Classification: Health & Mental Health Services (3370); Psychological Disorders (3210). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). References Available: Y. Page Count: 15. Issue Publication Date: Jul, 2003.
AB - The appalling young-adult outcomes of youth with serious emotional disturbance who are served in public systems demonstrate a failure of standard services to address the unique needs of these youths during their transition from adolescence to adulthood. This article discusses the needs of this population and the current ability of mental health and other relevant agencies to meet those needs. The contrast between needs and system status is presented through a framework of contrasting developmental and institutional transitions. This article reviews the barriers to effective system reform, and the recommendations for changes made by national panels focused on transition and applied research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - transitional youth
KW - adulthood
KW - young-adult outcomes
KW - serious emotional disturbance
KW - public systems
KW - mental health
KW - 2003
KW - Adolescent Development
KW - Emotional Disturbances
KW - Mental Health
KW - Needs
KW - Public Health Services
KW - Childhood Development
KW - 2003
DO - 10.1023/A:1025027117827
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-07261-002&site=ehost-live&scope=site
UR - maryann.davis@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-07261-004
AN - 2003-07261-004
AU - Teich, Judith L.
AU - Buck, Jeffrey A.
AU - Graver, Linda
AU - Schroeder, Don
AU - Zheng, Dian
T1 - Utilization of public mental health services by children with serious emotional disturbances.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2003/07//
VL - 30
IS - 6
SP - 523
EP - 524
CY - Germany
PB - Springer
SN - 0894-587X
AD - Teich, Judith L., SAMHSA/CMHS, 5600 Fishers Lane, 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2003-07261-004. Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Teich, Judith L.; Office of Organization and Financing, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, US. Release Date: 20030915. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Databases; Emotional Disturbances; Health Care Utilization; Public Health Services. Minor Descriptor: Drug Abuse; Drug Rehabilitation; Medicaid. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 2. Issue Publication Date: Jul, 2003.
AB - The Integrated Database (IDB) was created to provide a broad picture of the use of state-funded mental health (MH) and substance abuse (SA) services. Assembled separately for three states (Delaware, Oklahoma, and Washington), the IDB links client-level and service-level data maintained by the state MH, SA, and Medicaid agencies. This study used the IDB to examine public MH services for children with serious emotional disturbances (SED) in 1996. Children with SED represented 9% to 22% of all children with MH service use. Between one half and two thirds of children with SED received psychotropic medication; 20% to 40% had a MH inpatient or residential stay. Medicaid was the primary funder of MH services for children with SED; only 2% to 12% of children with SED received services solely through the state MH agency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public mental health services
KW - serious emotional disturbances
KW - Integrated Database
KW - state-funded mental health
KW - substance abuse services
KW - Medicaid
KW - health service utilization
KW - 2003
KW - Community Mental Health Services
KW - Databases
KW - Emotional Disturbances
KW - Health Care Utilization
KW - Public Health Services
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Medicaid
KW - 2003
DO - 10.1023/A:1025031218735
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-07261-004&site=ehost-live&scope=site
UR - jteich@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05864-001
AN - 2003-05864-001
AU - Buck, Jeffrey A.
T1 - Medicaid, health care financing trends, and the future of state-based public mental health services.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2003/07//
VL - 54
IS - 7
SP - 969
EP - 975
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Buck, Jeffrey A., Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2003-05864-001. PMID: 12851432 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20030908. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Funding; Health Care Costs; Medicaid; Mental Health Services; Trends. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 2003.
AB - Medicaid now funds more than half of public mental health services administered by states and could account for two-thirds of such spending by 2017. This trend and others represent a major shift in the predominant model by which public mental health services are funded, organized, and delivered. One model is associated with programs administered by state mental health authorities and is characterized by direct funding of designated community providers. This model is being displaced by one associated with state Medicaid programs, which are based on organization and financing methods characteristic of health insurance plans. This shift in models encompasses issues such as administrative authority, funding source, data collection, population served, services provided, and attitudes toward providers and consumers. Failure to understand these changes and their implications will probably have negative consequences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public mental health services
KW - mental health authorities
KW - health insurance plans
KW - financing
KW - Medicaid
KW - 2003
KW - Funding
KW - Health Care Costs
KW - Medicaid
KW - Mental Health Services
KW - Trends
KW - 2003
DO - 10.1176/appi.ps.54.7.969
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05864-001&site=ehost-live&scope=site
UR - jbuck@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99358-001
AN - 2003-99358-001
AU - Cabassa, Leopoldo J.
T1 - Integrating Cross-Cultural Psychiatry into the Study of Mental Health Disparities.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/07//
VL - 93
IS - 7
SP - 1034
EP - 1034
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Cabassa, Leopoldo J., Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1196, One Brookings Drive, St Louis, MO, US, 63130
N1 - Accession Number: 2003-99358-001. PMID: 12835167 Partial author list: First Author & Affiliation: Cabassa, Leopoldo J.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St Louis, MO, US. Release Date: 20031110. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Culture (Anthropological); Mental Health; Mental Health Services; Quality of Care; Transcultural Psychiatry. Minor Descriptor: Racial and Ethnic Differences; Sociocultural Factors; Health Disparities. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: Jul, 2003.
AB - Comments on an article by L. R. Snowden in the American Journal of Public Health, 2003, Vol 93, pp. 239-243, which presents a comprehensive review of the literature regarding the role that practitioners' bias plays in the development of racial and ethnic disparities in the current mental health system. This letter to the editor also discusses the integration of cross-cultural psychiatry into the study of mental health disparities. By citing studies done by other authors, the letter suggests that the role of the culture in the expression, presentation and course of mental illnesses and its integration into the current discussion of mental health disparities in service use and quality of care can help clarify and expand our understanding of the sociocultural processes that create these inequities. A multidisciplinary approach that combines epidemiological, clinical, and anthropological data can produce a better empirical base for determining the roots of mental health disparities and can inform the translation of this knowledge into practice to eliminate inequities in service use and quality of care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cross-cultural psychiatry
KW - mental health disparities
KW - culture
KW - mental illness
KW - quality of care
KW - mental health service
KW - inequities
KW - sociocultural processes
KW - 2003
KW - Culture (Anthropological)
KW - Mental Health
KW - Mental Health Services
KW - Quality of Care
KW - Transcultural Psychiatry
KW - Racial and Ethnic Differences
KW - Sociocultural Factors
KW - Health Disparities
KW - 2003
DO - 10.2105/AJPH.93.7.1034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99358-001&site=ehost-live&scope=site
UR - ljc1@gwbmail.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99358-002
AN - 2003-99358-002
AU - Snowden, Lonnie R.
T1 - Snowden responds.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/07//
VL - 93
IS - 7
SP - 1034
EP - 1035
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Snowden, Lonnie R., Center for Mental Health Services Research, University of California, 120 Haviland Hall, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2003-99358-002. Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, University of California, Berkeley, CA, US. Release Date: 20031110. Correction Date: 20170130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Culture (Anthropological); Mental Health; Mental Health Services; Transcultural Psychiatry. Minor Descriptor: Quality of Care; Racial and Ethnic Differences; Sociocultural Factors. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul, 2003.
AB - Response to the letter to the editor by Cabassa (see record [rid]2003-99358-001[/rid]) on 'Integrating cross-cultural psychiatry into the study of mental health disparities', which was a comment on the author's original article in the American Journal of Public Health, 2003, Vol 93, pp. 239-243, which presented a comprehensive review of the literature regarding the role that practitioners' bias plays in the development of racial and ethnic disparities in the current mental health system. Cabassa highlighted the importance of cultural factors, including culture-based differences in the expression of distress, in a comprehensive account of racial and ethnic disparities in mental health. Much more remains to be said, not only about culture, but also about the design of mental health programs, treatment financing, and many other barriers to care. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - cross-cultural psychiatry
KW - mental health disparities
KW - culture
KW - mental illness
KW - quality of care
KW - mental health service
KW - inequities
KW - sociocultural processes
KW - 2003
KW - Culture (Anthropological)
KW - Mental Health
KW - Mental Health Services
KW - Transcultural Psychiatry
KW - Quality of Care
KW - Racial and Ethnic Differences
KW - Sociocultural Factors
KW - 2003
DO - 10.2105/AJPH.93.7.1034-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99358-002&site=ehost-live&scope=site
UR - snowden@uclink4.berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99766-001
AN - 2003-99766-001
AU - Hariri, Ahmad R.
AU - Goldberg, Terry E.
AU - Mattay, Venkata S.
AU - Kolachana, Bhaskar S.
AU - Callicott, Joseph H.
AU - Egan, Michael F.
AU - Weinberger, Daniel R.
T1 - Brain-Derived Neurotrophic Factor val⁶⁶ met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2003/07//
VL - 23
IS - 17
SP - 6690
EP - 6694
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Weinberger, Daniel R., Clinical Brain Disorder Branch, National Institute of Mental Health, 10 Center Drive, Room 4S235, Bethesda, MD, US, 20892-1384
N1 - Accession Number: 2003-99766-001. PMID: 12890761 Partial author list: First Author & Affiliation: Hariri, Ahmad R.; Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institues of Health, United States Department of Health and Human Services, Bethesda, MD, US. Release Date: 20040628. Correction Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; Learning; Memory; Polymorphism; Brain Derived Neurotrophic Factor. Minor Descriptor: Neurotrophic Factor. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jul, 2003.
AB - BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene has been associated with abnormal intracellular trafficking and regulated secretion of BDNF in cultured hippocampal neurons transfected with the met allele. In addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of BDNF alleles on hippocampal processing of memory has not been demonstrated. We studied the relationship of the BDNF val⁶⁶met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals. Met carriers exhibited relatively diminished hippocampal engagement in comparison with val homozygotes during both encoding and retrieval processes. The interaction between the BDNF val⁶⁶met genotype and the hippocampal response during encoding accounted for 25% of the total variation in recognition memory performance. These data implicate a specific genetic mechanism for substantial normal variation in human declarative memory. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - polymorphism
KW - human memory
KW - hippocampal activity
KW - memory performance
KW - brain-derived neurotrophic factor
KW - neuroplasticity
KW - learning
KW - 2003
KW - Hippocampus
KW - Learning
KW - Memory
KW - Polymorphism
KW - Brain Derived Neurotrophic Factor
KW - Neurotrophic Factor
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99766-001&site=ehost-live&scope=site
UR - weinberd@intra.nimh.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Zaitseva, Marina
AU - Peden, Keith
AU - Golding, Hana
T1 - HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
JO - BBA - Biomembranes
JF - BBA - Biomembranes
Y1 - 2003/07/11/
VL - 1614
IS - 1
M3 - Article
SP - 51
SN - 00052736
AB - The human immunodeficiency virus (HIV) envelope glycoprotein forms trimers on the virion surface, with each monomer consisting of two subunits, gp120 and gp41. The gp120 envelope component binds to CD4 on target cells and undergoes conformational changes that allow gp120 to interact with certain G-protein-coupled receptors (GPCRs) on the same target membranes. The GPCRs that function as HIV coreceptors were found to be chemokine receptors. The primary coreceptors are CCR5 and CXCR4, but several other chemokine receptors were identified as “minor coreceptors”, indicating their ability support entry of some HIV strains in tissue cultures. Formation of the tri-molecular complexes stabilizes virus binding and triggers a series of conformational changes in gp41 that facilitate membrane fusion and viral cell entry. Concerted efforts are underway to decipher the specific interactions between gp120/CD4, gp120/coreceptors, and their contributions to the subsequent membrane fusion process. It is hoped that some of the transient conformational intermediates in gp120 and gp41 would serve as targets for entry inhibitors. In addition, the CD4 and coreceptors are primary targets for several classes of inhibitors currently under testing. Our review summarizes the current knowledge on the interactions of HIV gp120 with its receptor and coreceptors, and the important properties of the chemokine receptors and their regulation in primary target cells. We also summarize the classes of coreceptor inhibitors under development. [Copyright &y& Elsevier]
AB - Copyright of BBA - Biomembranes is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - HIV (Viruses)
KW - G proteins
KW - CD4-binding site (CD4bs)
KW - CD4-induced (CD4i)
KW - Entry-inhibitor
KW - extracellular domains I, of chemokine receptors (ECI)
KW - extracellular domains II, of chemokine receptors (ECII)
KW - extracellular domains III of chemokine receptors (ECIII)
KW - G-protein-coupled receptor (GPCR)
KW - heptad repeats in gp41 (HR)
KW - HIV envelope
KW - HIV receptor/coreceptor
KW - human immunodeficiency virus (HIV)
KW - monoclonal antibody (MAb)
KW - Viral-cell fusion
N1 - Accession Number: 10233567; Zaitseva, Marina 1 Peden, Keith 1 Golding, Hana; Email Address: goldingH@cber.fda.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Jul2003, Vol. 1614 Issue 1, p51; Subject Term: MONOCLONAL antibodies; Subject Term: HIV (Viruses); Subject Term: G proteins; Author-Supplied Keyword: CD4-binding site (CD4bs); Author-Supplied Keyword: CD4-induced (CD4i); Author-Supplied Keyword: Entry-inhibitor; Author-Supplied Keyword: extracellular domains I, of chemokine receptors (ECI); Author-Supplied Keyword: extracellular domains II, of chemokine receptors (ECII); Author-Supplied Keyword: extracellular domains III of chemokine receptors (ECIII); Author-Supplied Keyword: G-protein-coupled receptor (GPCR); Author-Supplied Keyword: heptad repeats in gp41 (HR); Author-Supplied Keyword: HIV envelope; Author-Supplied Keyword: HIV receptor/coreceptor; Author-Supplied Keyword: human immunodeficiency virus (HIV); Author-Supplied Keyword: monoclonal antibody (MAb); Author-Supplied Keyword: Viral-cell fusion; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0005-2736(03)00162-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10233567&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106729751
T1 - Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas.
AU - Reyes M
AU - Nisenbaum R
AU - Hoaglin DC
AU - Unger ER
AU - Emmons C
AU - Randall B
AU - Stewart JA
AU - Abbey S
AU - Jones JF
AU - Gantz N
AU - Minden S
AU - Reeves WC
Y1 - 2003/07/14/
N1 - Accession Number: 106729751. Language: English. Entry Date: 20040430. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Fatigue Syndrome, Chronic -- Epidemiology -- Kansas
KW - Kansas
KW - Fatigue Syndrome, Chronic -- Diagnosis
KW - Incidence
KW - Prevalence
KW - Prospective Studies
KW - Epidemiological Research
KW - Random Sample
KW - Data Analysis Software
KW - Chi Square Test
KW - Fisher's Exact Test
KW - Confidence Intervals
KW - Questionnaires
KW - Adult
KW - Middle Age
KW - Female
KW - Male
KW - Human
SP - 1530
EP - 1536
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 163
IS - 13
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 12860574.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106729751&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hwang, Dae Y.
AU - Cho, Jung S.
AU - Chae, Kab R.
AU - Kang, Tae S.
AU - Hwang, Jin H.
AU - Lim, Chae H.
AU - Lee, Su H.
AU - Lim, Hwa J.
AU - Min, Sae H.
AU - Sheen, Yhun Y.
AU - Jang, In S.
AU - Kim, Yong K.
T1 - Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2003/07/15/
VL - 415
IS - 2
M3 - Article
SP - 137
SN - 00039861
AB - Differential expression of the tetracycline-controlled transactivator (tTA)-driven human cytochrome P450 (CYP) 1B1 gene was found in the livers of male mice, at high levels in neonates, but at low levels in adults. The goals of this study were to determine whether the differential expression of the tTA-driven human CYP1B1 (hCYP1B1) gene in neonates and adults was testosterone dependent and whether flutamide, a representative potent antiandrogen, led to the induction of hCYP1B1. This was tested by treating castrated transgenic mice with testosterone propionate and musk extracts. It was concluded that: (i) the levels of expression of both tTA and hCYP1B1 gradually declined, with clear changes being apparent between 2 and 4 weeks of age, (ii) castration of adult males resulted in the increased expressions of both tTA and hCYP1B1 to levels similar to those found in adult females, (iii) treatment of castrated male and adult female mice with testosterone propionate and musk extracts led to the restoration of the levels of expression of hCYP1B1 in the adult males, and (iv) treatment of adult males with flutamide caused an increase in the levels of expression of hCYP1B1 in the adult females, as indicated by the antiandrogenic activity. Thus, the differential expression of the tTA-driven hCYP1B1 gene in the transgenic mice was caused by androgen, and it is possible that castrated male and adult female mice expressing the tTA-controlled hCYP1B1 could be used as the basis for a strategy for the detection of androgens and antiandrogens. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TETRACYCLINE
KW - TRANSGENIC animals
KW - Androgen
KW - Antiandrogen
KW - CYP1B1
KW - Flutamide
KW - Musk extract
KW - Testosterone
KW - Tetracycline
KW - Transactivator
KW - Transgenic
N1 - Accession Number: 10063705; Hwang, Dae Y. 1 Cho, Jung S. 1 Chae, Kab R. 1 Kang, Tae S. 1 Hwang, Jin H. 1 Lim, Chae H. 1 Lee, Su H. 1 Lim, Hwa J. 1 Min, Sae H. 1 Sheen, Yhun Y. 2 Jang, In S. 3 Kim, Yong K. 1; Email Address: kimyongkyu@hanmail.net; Affiliation: 1: Division of Laboratory Animal Resources, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea 2: College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea 3: Department of Animal Science, Chinju National University, RAIRC, Chinju Kyngnam, 660-758, Republic of Korea; Source Info: Jul2003, Vol. 415 Issue 2, p137; Subject Term: TETRACYCLINE; Subject Term: TRANSGENIC animals; Author-Supplied Keyword: Androgen; Author-Supplied Keyword: Antiandrogen; Author-Supplied Keyword: CYP1B1; Author-Supplied Keyword: Flutamide; Author-Supplied Keyword: Musk extract; Author-Supplied Keyword: Testosterone; Author-Supplied Keyword: Tetracycline; Author-Supplied Keyword: Transactivator; Author-Supplied Keyword: Transgenic; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0003-9861(03)00218-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10063705&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, Shaohua
AU - Datta, Atin R.
AU - Ayers, Sherry
AU - Friedman, Sharon
AU - Walker, Robert D.
AU - White, David G.
T1 - Antimicrobial-resistant Salmonella serovars isolated from imported foods
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2003/07/15/
VL - 84
IS - 1
M3 - Article
SP - 87
SN - 01681605
AB - A total of 187 Salmonella isolates representing 82 serotypes recovered from 4072 imported foods in the year 2000 by the U.S. Food and Drug Administration field laboratories were tested for their susceptibility to 17 antimicrobials of human and veterinary importance. Fifteen (8%) isolates were resistant to at least one antimicrobial, and five (2.7%) were resistant to three or more antimicrobials. Most of the isolates (n=9) exhibited resistance to tetracycline. Four isolates from catfish or tilapia from Taiwan or Thailand also demonstrated resistance to nalidixic acid. These nalidixic acid-resistant Salmonella isolates possessed a point mutation at the Ser83 or Asp87 position in DNA gryase, resulting in amino acid substitutions to phenylalanine, tyrosine, or asparagine. One Salmonella Derby isolated from frozen anchovies imported from Cambodia was resistant to six antimicrobials including ampicillin, amoxicillin/clavulanic acid, chloramphenicol, sulfamethoxazole, tetracycline, and trimethoprim/sulfamethoxazole. Of seven isolates displaying resistance to sulfonamides, only one S. Derby and one Salmonella Agona contained class 1 integrons that were further shown to possess the aadA and pse-1 genes conferring resistance to streptomycin and ampicillin, respectively. This study indicates that antimicrobial-resistant Salmonella are present in imported foods, primarily of seafood origin, and stresses the need for continued surveillance of foodborne zoonotic bacterial pathogens from imported foods entering the United States. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Anti-infective agents
KW - Antimicrobial resistance
KW - Imported foods
N1 - Accession Number: 9856371; Zhao, Shaohua 1; Email Address: szhao@cvm.fda.gov; Datta, Atin R. 2; Ayers, Sherry 1; Friedman, Sharon 1; Walker, Robert D. 1; White, David G. 1; Affiliations: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA; 2: Division of Field Science, Food and Drug Administration, Rockville, MD 20857, USA; Issue Info: Jul2003, Vol. 84 Issue 1, p87; Thesaurus Term: Salmonella; Thesaurus Term: Anti-infective agents; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Imported foods; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0168-1605(02)00402-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=9856371&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Santamaría, Abel
AU - Salvatierra-Sánchez, Raquel
AU - Vázquez-Román, Beatriz
AU - Santiago-López, Dario
AU - Villeda-Hernández, Juana
AU - Galván-Arzate, Sonia
AU - Jiménez-Capdeville, María E.
AU - Ali, Syed F.
T1 - Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2003/07/15/
VL - 86
IS - 2
M3 - Article
SP - 479
EP - 488
PB - Wiley-Blackwell
SN - 00223042
AB - Abstract Quinolinic acid (QUIN), a well known excitotoxin that produces a pharmacological model of Huntington's disease in rats and primates, has been shown to evoke degenerative events in nerve tissue via NMDA receptor (NMDAr) overactivation and oxidative stress. In this study, the antioxidant selenium (as sodium selenite) was tested against different markers of QUIN-induced neurotoxicity under both in vitro and in vivo conditions. In the in vitro experiments, a concentration-dependent effect of selenium was evaluated on the regional peroxidative action of QUIN as an index of oxidative toxicity in rat brain synaptosomes. In the in vivo experiments, selenium (0.625 mg per kg per day, i.p.) was administered to rats for 5 days, and 2 h later animals received a single unilateral striatal injection of QUIN (240 nmol/µL). Rats were killed 2 h after the induction of lesions with QUIN to measure lipid peroxidation and glutathione peroxidase (GPx) activity in striatal tissue. In other groups, the rotation behavior, GABA content, morphologic alterations, and the corresponding ratio of neuronal damage were all evaluated as additional markers of QUIN-induced striatal toxicity 7 days after the intrastriatal injection of QUIN. Selenium decreased the peroxidative action of QUIN in synaptosomes both from whole rat brain and from the striatum and hippocampus, but not in the cortex. A protective concentration-dependent effect of selenium was observed in QUIN-exposed synaptosomes from whole brain and hippocampus. Selenium pre-treatment decreased the in vivo lipid peroxidation and increased the GPx activity in QUIN-treated rats. Selenium also significantly attenuated the QUIN-induced circling behavior, the striatal GABA depletion, the ratio of neuronal damage, and partially prevented the morphologic alterations in rats. These data suggest that major features of QUIN-induced neurotoxicity are partially mediated by free radical formation and oxidative stress, and that selenium... [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIOXIDANTS
KW - SELENIUM
KW - QUINOLINIC acid
KW - NEUROTOXICOLOGY
KW - antioxidant defense
KW - excitotoxin
KW - N -methyl-d-aspartate receptor
KW - neurotoxicity
KW - quinolinic acid
KW - selenium
N1 - Accession Number: 10144274; Santamaría, Abel 1,2 Salvatierra-Sánchez, Raquel 1 Vázquez-Román, Beatriz 1 Santiago-López, Dario 1 Villeda-Hernández, Juana 3 Galván-Arzate, Sonia 1 Jiménez-Capdeville, María E. 1 Ali, Syed F. 2; Affiliation: 1: Departamento de Neuroquímica and 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA 3: Neuromorfología Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico; Source Info: 7/15/2003, Vol. 86 Issue 2, p479; Subject Term: ANTIOXIDANTS; Subject Term: SELENIUM; Subject Term: QUINOLINIC acid; Subject Term: NEUROTOXICOLOGY; Author-Supplied Keyword: antioxidant defense; Author-Supplied Keyword: excitotoxin; Author-Supplied Keyword: N -methyl-d-aspartate receptor; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: quinolinic acid; Author-Supplied Keyword: selenium; Number of Pages: 10p; Document Type: Article
L3 - 10.1046/j.1471-4159.2003.01857.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10144274&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvartsburg, Alexandre A.
T1 - Aromatic ring destruction in complexes of dipositive metal cations
JO - Chemical Physics Letters
JF - Chemical Physics Letters
Y1 - 2003/07/17/
VL - 376
IS - 1/2
M3 - Article
SP - 6
SN - 00092614
AB - Singly charged metal cations do not normally activate the π-ring in monoaromatic ligands. Here pyridine complexes of six dipositive metal cations (Ca, Mg, Mn, Fe, Co, and Cu) are probed using collisional dissociation. Except for Cu, species with one–three ligands (depending on the metal) exhibit two significant aromaticity-destroying ligand cleavage processes. One proceeds with charge reduction yielding singly charged bare or ligated metal cyanide cations and C4H5+, and the other retains the double charge eliminating one or two small neutrals such as NH2 or CH3. The previously reported cluster-to-metal charge transfer producing charged ligand clusters is shown to not occur. [Copyright &y& Elsevier]
AB - Copyright of Chemical Physics Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METAL ions
KW - CATIONS
KW - CHARGE transfer
N1 - Accession Number: 10233126; Shvartsburg, Alexandre A. 1; Email Address: alexandre.shvartsburg@pnl.gov; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, HFT-233, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jul2003, Vol. 376 Issue 1/2, p6; Subject Term: METAL ions; Subject Term: CATIONS; Subject Term: CHARGE transfer; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0009-2614(03)00815-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10233126&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106711301
T1 - West Nile virus.
AU - Petersen LR
AU - Marfin AA
AU - Gubler DJ
AU - Petersen, Lyle R
AU - Marfin, Anthony A
AU - Gubler, Duane J
A2 - Lovinger SP
Y1 - 2003/07/23/
N1 - Accession Number: 106711301. Language: English. Entry Date: 20040312. Revision Date: 20161112. Publication Type: journal article; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - West Nile Fever
KW - Disease Outbreaks
KW - Geographic Factors
KW - Mosquitoes
KW - West Nile Fever -- Epidemiology
KW - West Nile Fever -- Microbiology
KW - West Nile Fever -- Physiopathology
KW - West Nile Fever -- Prevention and Control
KW - West Nile Fever -- Transmission
SP - 524
EP - 528
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 290
IS - 4
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Fort Collins, Colo, USA
AD - Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, PO Box 2087, Foothills Campus, Fort Collins, CO 80522; LRPetersen@CDC.GOV
U2 - PMID: 12876096.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brown, Kenneth K.
AU - Cheever, Kenneth L.
AU - Butler, Mary Ann
AU - Shaw, Peter B.
AU - McLaurin, Jeffery L.
T1 - Synthesis, characterization, and use of 2-[(2H9)butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid as an internal standard and an instrument performance surrogate, respectively, for the gas chromatographic–mass spectrometric determination of 2-butoxyacetic acid, a human metabolite of 2-butoxyethanol
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2003/07/25/
VL - 792
IS - 2
M3 - Article
SP - 153
SN - 15700232
AB - 2-[(2H9)Butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid were synthesized, mixed with 2-butoxyacetic acid, and separated by capillary gas chromatography on a fused-silica column with a length of 50 m, inside diameter of 0.200 mm, and a “free fatty acid phase” wall coating of 0.3 μm film. 2-[(2H9)Butoxy]acetic acid, 2-butoxyacetic acid, and 2-(3-methylbutoxy)acetic acid were baseline resolved at retention times of 13.55, 13.78, and 15.20 min; 2-(3-methylbutoxy)acetic acid having a peak efficiency of 360 000. Mass spectrometric detection using selected ion monitoring at m/z 66, 57, and 71 showed linear analytical responses from 0.04 ng to at least 200 ng with a limit of detection of 0.04 ng for 2-butoxyacetic acid. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETIC acid
KW - FUSED silica
KW - CHROMATOGRAPHIC analysis
KW - SILICA
KW - CAPILLARY electrophoresis
KW - 2-Butoxyacetic acid
N1 - Accession Number: 10176633; Brown, Kenneth K.; Email Address: krb1@cdc.gov Cheever, Kenneth L. 1 Butler, Mary Ann 1 Shaw, Peter B. 1 McLaurin, Jeffery L. 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, R-7 Cincinnati, OH 45226, USA; Source Info: Jul2003, Vol. 792 Issue 2, p153; Subject Term: ACETIC acid; Subject Term: FUSED silica; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: SILICA; Subject Term: CAPILLARY electrophoresis; Author-Supplied Keyword: 2-Butoxyacetic acid; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/S1570-0232(03)00256-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10176633&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ramírez, Tzutzuy
AU - García-Montalvo, Verónica
AU - Wise, Carolyn
AU - Cea-Olivares, Raymundo
AU - Poirier, Lionel A.
AU - Herrera, Luis A.
T1 - S-adenosyl-l-methionine is able to reverse micronucleus formation induced by sodium arsenite and other cytoskeleton disrupting agents in cultured human cells
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/07/25/
VL - 528
IS - 1/2
M3 - Article
SP - 61
SN - 00275107
AB - Deficiencies of folic acid and methionine, two of the major components of the methyl metabolism, correlate with an increment of chromosome breaks and micronuclei. It has been proposed that these effects may arise from a decrease of S-adenosyl-l-methionine (SAM), the universal methyl donor. Some xenobiotics, such as arsenic, originate a reduction of SAM levels, and this is believed to alter some methylation processes (e.g. DNA methylation). The aim of the present work was to analyze the effects of exogenous SAM on the micronucleus (MN) frequency induced by sodium arsenite in human lymphocytes treated in vitro and to investigate whether these effects are related to DNA methylation. Results showed a reduction in the MN frequency in cultures treated with sodium arsenite and SAM compared to those treated with arsenite alone. To understand the mechanism by which SAM reduced the number of micronucleated cells, its effect on MN induced by other xenobiotics was also analyzed. Results showed that SAM did not have any effect on the increase in MN frequency caused by alkylating (mitomycin C or cisplatin) or demethylating agents (5-azacytidine, hydralazine, ethionine and procainamide), but it reduced the number of micronucleated cells in those treated with agents that inhibit microtubule polymerization (albendazole sulphoxide and colcemid). Since albendazole sulphoxide and colcemid inhibit microtubule polymerization, we decided to evaluate the effect of SAM on microtubule integrity. Data obtained from these evaluations showed that sodium arsenite, albendazole sulphoxide, and colcemid affect the integrity and organization of microtubules and that these effects are significantly reduced when cultures were treated at the same time with SAM. The data taken all together point out that the positive effects of SAM could be due to its ability to protect microtubules through an unknown mechanism. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - METHIONINE
KW - CHROMOSOMES
KW - Fibroblasts
KW - Lymphocytes
KW - Micronucleus
KW - NMR
KW - SAM
N1 - Accession Number: 10233716; Ramírez, Tzutzuy 1 García-Montalvo, Verónica 2 Wise, Carolyn 3 Cea-Olivares, Raymundo 2 Poirier, Lionel A. 3 Herrera, Luis A. 1; Email Address: metil@hotmail.com; Affiliation: 1: Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM—Instituto Nacional de Cancerología, México, Mexico 2: Instituto de Química, UNAM, México, Mexico 3: National Center for Toxicological Research, Little Rock, AR, USA; Source Info: Jul2003, Vol. 528 Issue 1/2, p61; Subject Term: FOLIC acid; Subject Term: METHIONINE; Subject Term: CHROMOSOMES; Author-Supplied Keyword: Fibroblasts; Author-Supplied Keyword: Lymphocytes; Author-Supplied Keyword: Micronucleus; Author-Supplied Keyword: NMR; Author-Supplied Keyword: SAM; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/S0027-5107(03)00099-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10233716&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gans, Hayley
AU - DeHovitz, Ross
AU - Forghani, Bagher
AU - Beeler, Judith
AU - Maldonado, Yvonne
AU - Arvin, Ann M.
T1 - Measles and mumps vaccination as a model to investigate the developing immune system: passive and active immunity during the first year of life
JO - Vaccine
JF - Vaccine
Y1 - 2003/07/28/
VL - 21
IS - 24
M3 - Article
SP - 3398
SN - 0264410X
AB - Evaluations of neutralizing antibody responses in 6-, 9- and 12-month-old infants given measles or mumps vaccine indicated that 6-month-old infants had diminished humoral immune responses associated with passive antibody effects, but also had an intrinsic deficiency in antiviral antibody production, which was independent of passive antibody effects. In contrast, lower neutralizing antibody titers in 9-month-olds were related only to passive antibody effects. Measles and mumps-specific T-cell proliferation and interferon-gamma (IFNγ) production were induced by vaccination at 6, 9 or 12 months, regardless of passive neutralizing antibodies or age. These observations suggest a need to refine concepts about passive antibody interference and primary vaccine failure, taking into account the sensitization of antiviral T-cells, which occurs in the presence of passive antibodies and is observed in infants who do not develop active humoral immunity. A second dose of measles vaccine given at 12–15 months enhanced antiviral T-cell responses to measles in infants who were vaccinated at 6 or 9 months, and produced higher seroconversion rates. Since T-cell immunity is elicited under the cover of passive antibodies, the youngest infants benefit from the synergistic protection mediated by maternal antibodies and their own capacity to develop sensitized antiviral T-cells, which prime for subsequent exposures to the viral antigens. Conceptually, maternal immunization approaches with vaccines that can be given to women of child-bearing age before pregnancy, or that are safe for administration during pregnancy, should enhance passive antibody protection. Rather than being detrimental to infant adaptive immune responses, maternal vaccination can be coupled effectively with vaccine regimens that elicit priming of antiviral immune responses in infants during the first year of life. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MEASLES
KW - Antiviral
KW - Cellular immunity
KW - Developmental immunology
KW - Measles
KW - Mumps
N1 - Accession Number: 10177421; Gans, Hayley 1 DeHovitz, Ross 2 Forghani, Bagher 3 Beeler, Judith 4 Maldonado, Yvonne 1 Arvin, Ann M. 1; Email Address: aarvin@stanford.edu; Affiliation: 1: Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Rm G312, Stanford, CA 94305-5208, USA 2: Department of Pediatrics, Palo Alto Medical Foundation, Palo Alto, CA, USA 3: Department of Health Services, Viral and Rickettsial Disease Laboratory, California State, Richmond, CA, USA 4: Division of Viral Products, Food and Drug Administration, Bethesda, MD, USA; Source Info: Jul2003, Vol. 21 Issue 24, p3398; Subject Term: IMMUNOGLOBULINS; Subject Term: MEASLES; Author-Supplied Keyword: Antiviral; Author-Supplied Keyword: Cellular immunity; Author-Supplied Keyword: Developmental immunology; Author-Supplied Keyword: Measles; Author-Supplied Keyword: Mumps; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0264-410X(03)00341-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10177421&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gruber, Marion F.
T1 - Maternal immunization: US FDA regulatory considerations
JO - Vaccine
JF - Vaccine
Y1 - 2003/07/28/
VL - 21
IS - 24
M3 - Article
SP - 3487
SN - 0264410X
AB - Vaccination of pregnant women provides important health benefits to both, mother and infant, and has been an important disease prevention strategy in these two groups. While most vaccines currently licensed in the US are not indicated for use during pregnancy, depending on the vaccine, vaccination programs do frequently include pregnant women. In addition, recent emphasis has been placed on maternal immunization strategies to protect young infants from severe infections. Currently, unless the vaccine is specifically indicated four maternal immunization, no data are collected regarding the vaccine’s safety in pregnant women prior to licensure. However, more females of childbearing age participate in clinical trials and a broad range of novel vaccine products are in development indicated for adolescents and adults. Thus, there is increasing concern for the unintentional exposure of an embryo/fetus before information is available regarding the potential risk versus benefit of the vaccine. Since pregnant women are usually excluded from participation in clinical trials, conclusions regarding developmental risk at the time of licensure are frequently based solely on data derived from developmental toxicity studies in animal models. This paper will review regulatory, preclinical and clinical issues as they pertain to development programs for vaccines intended for vaccination during pregnancy. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANT women
KW - VACCINATION
KW - Developmental toxicity
KW - Maternal immunization
KW - Pregnancy
KW - Prenatal immunization
KW - Regulatory consideration
KW - Vaccine
N1 - Accession Number: 10177440; Gruber, Marion F. 1; Email Address: gruber@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research (CBER), US FDA, Woodmont Office Complex 1 Rockville Pike, Rockville, MD 20852, USA; Source Info: Jul2003, Vol. 21 Issue 24, p3487; Subject Term: PREGNANT women; Subject Term: VACCINATION; Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: Maternal immunization; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: Prenatal immunization; Author-Supplied Keyword: Regulatory consideration; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0264-410X(03)00357-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10177440&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, Damien
AU - Minton, Allen P.
T1 - Macromolecular crowding: qualitative and semiquantitative successes, quantitative challenges
JO - BBA - Proteins & Proteomics
JF - BBA - Proteins & Proteomics
Y1 - 2003/07/30/
VL - 1649
IS - 2
M3 - Article
SP - 127
SN - 15709639
AB - The concept of excluded volume and the theory of effects of excluded volume on the equilibria and rates of macromolecular reactions in fluid media containing high total concentrations of macromolecules (‘crowded’ media) are summarized. Reports of experimental studies of crowding effects published during the last year are tabulated. Limitations of current excluded volume theory are discussed, and a determination is made of conditions under which this theory may and may not be validly applied. Recently suggested novel approaches to quantitative analysis of crowding phenomena, which may help to overcome some of the limitations of current theory, are summarized. [Copyright &y& Elsevier]
AB - Copyright of BBA - Proteins & Proteomics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROMOLECULES
KW - MOLECULES
KW - EQUILIBRIUM
KW - QUANTITATIVE chemical analysis
KW - FLUIDS
KW - Excluded volume
KW - Macromolecular solution
KW - Thermodynamic nonideality
N1 - Accession Number: 10320247; Hall, Damien 1 Minton, Allen P.; Email Address: minton@helix.nih.gov; Affiliation: 1: Section on Physical Biochemistry, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Building 8, Room 226, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-0830, USA; Source Info: Jul2003, Vol. 1649 Issue 2, p127; Subject Term: MACROMOLECULES; Subject Term: MOLECULES; Subject Term: EQUILIBRIUM; Subject Term: QUANTITATIVE chemical analysis; Subject Term: FLUIDS; Author-Supplied Keyword: Excluded volume; Author-Supplied Keyword: Macromolecular solution; Author-Supplied Keyword: Thermodynamic nonideality; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S1570-9639(03)00167-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10320247&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - B. STRAW, ROGER
T1 - The Northwestern “Experience”
JO - American Journal of Evaluation
JF - American Journal of Evaluation
Y1 - 2003///Summer2003
VL - 24
IS - 2
M3 - Article
SP - 281
SN - 10982140
N1 - Accession Number: 10276947; B. STRAW, ROGER 1; Email Address: rstraw@hrsa.gov; Affiliation: 1: Roger Straw • Director, Division of Knowledge Management Services, Office of Information Technology, Health Resources and Services Administration, Department of Health and Human Services, Room 10-05, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857, USA; Tel: (1) 301-443-0367; Fax: (1) 301-443-5868; Source Info: Summer2003, Vol. 24 Issue 2, p281; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/S1098-2140(03)00029-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10276947&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hsu, Leslie D.
AU - DeJong, William
AU - Hsia, Renee
AU - Chang, Michael
AU - Ryou, Marvin
AU - Yeh, Ellen
T1 - Student Leadership in Public Health Advocacy: Lessons Learned From the Hepatitis B Initiative.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2003/08//
VL - 93
IS - 8
M3 - Article
SP - 1250
EP - 1252
PB - American Public Health Association
SN - 00900036
AB - Increasing hepatitis B vaccination rates for Asian Americans and Pacific Islanders is a priority. Laws requiring vaccination prior to school enrollment have helped, yet many youths remain unvaccinated. The Hepatitis B Initiative (HBI), launched in 1997 and operated by public health and medical school students, provides free screenings and vaccinations to Boston's Asian American/Pacific Islander community, with a focus on youths. By October 2002, 997 HBI patients from Boston's Chinatown had received free hepatitis B screenings. Of these, 384 patients (39%) were deemed susceptible to the hepatitis B virus and provided with free vaccination. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B -- Vaccination
KW - ASIAN Americans
KW - PACIFIC Islanders
KW - MEDICAL students
KW - PUBLIC health
N1 - Accession Number: 10595988; Hsu, Leslie D. 1 DeJong, William 2; Email Address: wdejong@bu.edu Hsia, Renee 3 Chang, Michael 3 Ryou, Marvin 3 Yeh, Ellen 4; Affiliation: 1: Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC 2: Boston University of School of Public Health, Boston, Mass. 3: Harvard Medical School, Boston, Mass. 4: Harvard College, Boston, Mass.; Source Info: Aug2003, Vol. 93 Issue 8, p1250; Subject Term: HEPATITIS B -- Vaccination; Subject Term: ASIAN Americans; Subject Term: PACIFIC Islanders; Subject Term: MEDICAL students; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 2 Black and White Photographs; Document Type: Article; Full Text Word Count: 1758
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106713568
T1 - Field action report. Student leadership in public health advocacy: lessons learned from the hepatitis B initiative.
AU - Hsu LD
AU - DeJong W
AU - Hsia R
AU - Chang M
AU - Ryou M
AU - Yeh E
Y1 - 2003/08//
N1 - Accession Number: 106713568. Language: English. Entry Date: 20040319. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Consumer Advocacy -- Massachusetts
KW - Hepatitis B -- Prevention and Control -- Massachusetts
KW - Immunization Programs -- Massachusetts
KW - Leadership
KW - Public Health -- Education
KW - Asians
KW - Community Health Services -- Administration
KW - Hepatitis B -- Ethnology
KW - Massachusetts
KW - Students, Graduate
KW - Volunteer Workers
SP - 1250
EP - 1252
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 93
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Increasing hepatitis B vaccination rates for Asian Americans and Pacific Islanders is a priority. Laws requiring vaccination prior to school enrollment have helped, yet many youths remain unvaccinated. The Hepatitis B Initiative (HBI), launched in 1997 and operated by public health and medical school students, provides free screenings and vaccinations to Boston's Asian American/Pacific Islander community, with a focus on youths. By October 2002, 997 HBI patients from Boston's Chinatown had received free hepatitis B screenings. Of these, 384 patients (39%) were deemed susceptible to the hepatitis B virus and provided with free vaccination.
SN - 0090-0036
AD - Officer of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC
U2 - PMID: 12893606.
DO - 10.2105/AJPH.93.8.1250
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106713568&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106731701
T1 - Guest editorial. Effect of anti-IgE therapy in patients with food allergy.
AU - Nicklas RA
AU - Chowdhury BA
Y1 - 2003/08//2003 Aug
N1 - Accession Number: 106731701. Language: English. Entry Date: 20040507. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: Leung DYM, Sampson HA, Yunginger JW, Burks AW Jr., Schneider LC, Wortel CH, et al. Effect of anti-IgE therapy in patients with peanut allergy. (N ENGL J MED) 3/13/2003; 348 (11): 986-993. Commentary: Leung DYM, Shanahan WR Jr., Sampson HA. Guest editorial. Response to 'effect of anti-IgE therapy in patients with food allergy'. (ANN ALLERGY ASTHMA IMMUNOL) 2003 Dec; 91 (6): 515-517. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9503580.
KW - Food Hypersensitivity -- Drug Therapy
KW - Antibodies, Monoclonal -- Therapeutic Use
KW - Nuts
SP - 119
EP - 120
JO - Annals of Allergy, Asthma & Immunology
JF - Annals of Allergy, Asthma & Immunology
JA - ANN ALLERGY ASTHMA IMMUNOL
VL - 91
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1081-1206
AD - Division of Pulmonary Allergy and Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland
U2 - PMID: 12952103.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106731701&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - C.J. Hines
AU - J.A. Deddens
AU - C.A.F. Striley
AU - R.E. Biagini
AU - D.A. Shoemaker
AU - K.K. Brown
AU - B.A. Mackenzie
AU - R.D. Hull
T1 - Biological Monitoring for Selected Herbicide Biomarkers in the Urine of Exposed Custom Applicators: Application of Mixed-effect Models.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2003/08//
VL - 47
IS - 6
M3 - Article
SP - 503
EP - 517
SN - 00034878
AB - Metabolites and/or parent compounds of the herbicides atrazine, alachlor, metolachlor, cyanazine and the 2-ethylhexyl ester of 2,4-dichlorophenoxyacetic acid (2,4-D) were measured in the urine of 15 custom applicators who each provided from five to seven 24 h urine samples during a 6 week period (n = 87). Each applicator provided a pre-season urine sample and a reference population (n = 46) provided first-morning urine samples. Urinary biomarkers were measured by either immunoassay or gas chromatography. During the spraying season, the geometric mean amount of alachlor mercapturate equivalents (eq.), atrazine eq., 2,4-D and metolachlor mercapturate eq. excreted in 24 h was 17, 19, 110 and 22 nmol, respectively. Mixed-effect models were used to determine predictors of the amount of atrazine eq. and 2,4-D excreted in 24 h. The specific days of herbicide spraying associated with increased biomarker excretion varied for the two analytes, and included one or more days prior to urine collection. This confirms the importance of collecting covariate information on day(s) most relevant to the biomarker of interest. The within-worker variance component, expressed as a geometric standard deviation (WGSD range: 2.5-2.9), was substantially larger than the between-worker component (BGSD range: 1.3-1.5) for the modeled biomarkers. Alachlor mercapturate eq. and metolachlor mercapturate eq. were detected in more than half of the applicator pre-season urine samples. All biomarkers were detected infrequently in the reference population. Evaluation of non-spray exposure determinants was limited by inclusion of prior day spraying, adjustment for time and the small sample size. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metabolites
KW - Herbicides
KW - Esters
N1 - Accession Number: 10502188; C.J. Hines 1; J.A. Deddens 1; C.A.F. Striley 1; R.E. Biagini 1; D.A. Shoemaker 1; K.K. Brown 1; B.A. Mackenzie 1; R.D. Hull 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH, 45226, USA; Issue Info: Aug2003, Vol. 47 Issue 6, p503; Thesaurus Term: Metabolites; Thesaurus Term: Herbicides; Subject Term: Esters; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Satoshi Okada
AU - Elizabeth Weatherhead
AU - Ira N. Targoff
AU - Robert Wesley
AU - Frederick W. Miller
T1 - Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2003/08//
VL - 48
IS - 8
M3 - Article
SP - 2285
SN - 00043591
AB - To determine if geoclimatic factors may influence the nature and frequency of dermatomyositis (DM), polymyositis, and associated autoantibodies around the world. We assessed, in the first global evaluation of these conditions, the relationship between 13 geoclimatic variables that may modulate disease and the relative proportion of DM and its associated autoantibody antiMi-2, directed against an SNF2-superfamily helicase associated with the nucleosome remodeling and histone acetylation and deacetylation complex, in a global myositis population. Altogether, 919 consecutive patients from populations at 15 locations were studied. Univariate and multivariate analyses demonstrated that of the variables evaluated, surface ultraviolet (UV) radiation intensity (irradiance) most strongly contributed to the relative proportion of DM and was strongly related to the proportion of antiMi-2 autoantibodies (weighted r = 0.939, P < 4 × 10-7 and weighted r = 0.69, P = 0.02, respectively). Published ethnogeographic immunogenetic allele frequencies imply that the striking differences in the proportion of DM- and DM-specific autoantibodies observed around the world are not the result of inherent global variations in known genetic risk factors. These data suggest that UV radiation exposure may modulate the clinical and immunologic expression of an autoimmune disease in different populations around the world. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATOMYOSITIS
KW - CUTANEOUS manifestations of general diseases
KW - MYOSITIS
KW - AUTOANTIBODIES
KW - ULTRAVIOLET radiation
KW - AUTOIMMUNE diseases
KW - MUSCLES -- Diseases
N1 - Accession Number: 11352551; Satoshi Okada 1 Elizabeth Weatherhead 2 Ira N. Targoff 3 Robert Wesley 4 Frederick W. Miller 5; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 2: Cooperative Institute for Research in the Environmental Sciences, University of Colorado, Boulder 3: Oklahoma Medical Research Foundation, Oklahoma City 4: NIH Clinical Center, Bethesda, Maryland 5: National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland; Source Info: Aug2003, Vol. 48 Issue 8, p2285; Subject Term: DERMATOMYOSITIS; Subject Term: CUTANEOUS manifestations of general diseases; Subject Term: MYOSITIS; Subject Term: AUTOANTIBODIES; Subject Term: ULTRAVIOLET radiation; Subject Term: AUTOIMMUNE diseases; Subject Term: MUSCLES -- Diseases; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Richard J.
AU - Tepper, Shirley
AU - Diwan, Bhalchandra A.
AU - Anderson, Lucy M.
AU - Kritchevsky, David
T1 - Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2003/08//
VL - 66
IS - 3
M3 - Article
SP - 393
SN - 00062952
AB - Hypocholesterolemic drugs may themselves increase (cholestyramine, CS) or decrease (lovastatin, Lov) peripheral tissue de novo cholesterol biosynthesis. This will alter the abundance of prenyl groups and potentially increase (CS) or decrease (Lov) K-ras membrane localization, with possible pro- or anti-carcinogenic effects (K-ras is a proto-oncogene frequently mutated in lung cancer). Female A/J, Swiss, and C57BL/6 mice were fed 2 or 4% CS, 1% niacin, or injected with Lov three (Lov-3×) or five (Lov-5×) times per week. After three weeks, serum cholesterol and triglycerides were determined enzymatically. Total, membrane, and cytoplasmic K-ras proteins were determined in lung homogenates by immunoprecipitation followed by Western blotting with a K-ras specific antibody. CS feeding increased membrane K-ras as hypothesized in A/J and C57BL/6 mice, but had no effect in Swiss mice. Lov failed in all three strains to reduce membrane K-ras, and resulted in an increase in total K-ras in A/J and C57BL/6 mice, while again lacking effect in Swiss mice. Niacin had no effect on K-ras protein in any mouse strain. These results differ from our published results for male mice of the same strains, particularly for A/J mice. Increased amounts of K-ras protein in the membrane fraction of A/J females (but not males) treated with either Lov or CS imply that if K-ras were to become mutated, CS could result in increased lung tumorigenesis and Lov would be less likely to be protective in females. In the light of these data, both sexes should be included in future animal and human chemoprevention trials. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSYNTHESIS
KW - LUNGS -- Cancer
KW - CARCINOGENESIS
KW - 7,12-dimethylbenz[a]anthracene (DMBA)
KW - Cholesterol
KW - Cholestyramine
KW - cholestyramine (CS)
KW - d,l-dithiothreitol (DTT)
KW - hydroxymethylglutaryl coenzyme A reductase (HMG-CoA reductase)
KW - K-ras
KW - Lovastatin
KW - lovastatin 25 mg/kg five times per week (Lov-5×)
KW - lovastatin 25 mg/kg three times per week (Lov-3×)
KW - Lung
KW - Mouse
KW - Niacin
KW - phenylmethylsulfonylfluoride (PMSF)
KW - phosphate buffered saline with 0.1% Tween 20, pH 7.5 (PBS-T)
KW - Sex difference
N1 - Accession Number: 10427803; Calvert, Richard J. 1,2; Email Address: calvert@mail.ncifcrf.gov Tepper, Shirley 3 Diwan, Bhalchandra A. 4 Anderson, Lucy M. 2 Kritchevsky, David 3; Affiliation: 1: Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA 2: Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Rm. 227, Frederick, MD 21702, USA 3: The Wistar Institute, Philadelphia, PA 19104, USA 4: Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA; Source Info: Aug2003, Vol. 66 Issue 3, p393; Subject Term: BIOSYNTHESIS; Subject Term: LUNGS -- Cancer; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: 7,12-dimethylbenz[a]anthracene (DMBA); Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: Cholestyramine; Author-Supplied Keyword: cholestyramine (CS); Author-Supplied Keyword: d,l-dithiothreitol (DTT); Author-Supplied Keyword: hydroxymethylglutaryl coenzyme A reductase (HMG-CoA reductase); Author-Supplied Keyword: K-ras; Author-Supplied Keyword: Lovastatin; Author-Supplied Keyword: lovastatin 25 mg/kg five times per week (Lov-5×); Author-Supplied Keyword: lovastatin 25 mg/kg three times per week (Lov-3×); Author-Supplied Keyword: Lung; Author-Supplied Keyword: Mouse; Author-Supplied Keyword: Niacin; Author-Supplied Keyword: phenylmethylsulfonylfluoride (PMSF); Author-Supplied Keyword: phosphate buffered saline with 0.1% Tween 20, pH 7.5 (PBS-T); Author-Supplied Keyword: Sex difference; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0006-2952(03)00211-9
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Laughren, Thomas P.
T1 - Comorbid mood disorders and medical illness: a Food and Drug Administration perspective
JO - Biological Psychiatry
JF - Biological Psychiatry
Y1 - 2003/08//
VL - 54
IS - 3
M3 - Editorial
SP - 195
SN - 00063223
N1 - Accession Number: 10356856; Laughren, Thomas P. 1; Affiliation: 1: Food and Drug Administration (HFD-120), 1451 Rockville Pike, Rockville, MD 20857, USA; Source Info: Aug2003, Vol. 54 Issue 3, p195; Number of Pages: 5p; Document Type: Editorial
L3 - 10.1016/S0006-3223(03)00529-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Musser, Steven M.
AU - Egorin, Merrill J.
AU - Zuhowski, Eleanor G.
AU - Hamburger, Deborah R.
AU - Parise, Robert A.
AU - Covey, Joseph M.
AU - White, Kevin D.
AU - Eiseman, Julie L.
T1 - Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats.
JO - Cancer Chemotherapy & Pharmacology
JF - Cancer Chemotherapy & Pharmacology
Y1 - 2003/08//
VL - 52
IS - 2
M3 - Article
SP - 139
EP - 146
SN - 03445704
AB - Purpose. 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), an analogue of the benzoquinone ansamycin geldanamycin, has been extensively studied preclinically and is being evaluated clinically. Studies were performed to define the biliary excretion of 17AAG after i.v. delivery to rats, and to characterize the metabolites of 17AAG observed in rat bile. Materials and methods. In vivo studies were performed in bile-duct-cannulated Fischer 344 rats given a 10 mg/kg i.v. bolus dose of 17AAG. In vitro studies were performed with cloned human CYPs and microsomal epoxide hydrolase. Biliary excretion of 17AAG and metabolites was quantified by HPLC and followed for 4 h after drug delivery. 17AAG metabolites in bile and in in vitro reaction mixtures were identified with LC/MS/MS. Results. By 15 min after i.v. delivery of 17AAG, bile contained at least 15 biotransformation products with absorbance spectra similar to that of 17AAG. Of these, metabolites eluting at 2.7, 2.9, and 8.6 min were present in sufficient concentrations to be quantified, although the lack of authentic standards resulted in their being expressed as 17AAG equivalents. Within the first 4 h after drug delivery, biliary excretion accounted for 28.9±6.1% of the 10-mg/kg 17AAG dose. 17AAG and 17-(amino)-17-demethoxygeldanamycin (17AG) accounted for 4.1±1.0% of the delivered dose, with 17AAG accounting for 2.0±0.5% and 17AG accounting for 2.1±0.5%. The metabolites eluting at 2.7, 2.9, and 8.6 min accounted for 10.6±2.0%, 9.8±1.2%, and 1.0±0.2%, respectively, of the administered dose. LC/MS/MS analysis of bile demonstrated major metabolites with molecular weights of 545 and 619, corresponding to 17AG and the diol previously described as resulting from metabolism of 17AAG by CYP3A and microsomal epoxide hydrolase. Of the remaining proposed metabolites, ten had a mass and MS/MS spectrum consistent with mono-oxygenated 17AAG metabolites. One of these metabolites has been identified as the epoxide previously described as resulting from CYP3A oxidation of the allyl double bond. Two other proposed metabolites had a mass and MS/MS spectrum consistent with demethylated 17AAG metabolites, and one had a mass and MS/MS spectrum consistent with a di-demethylated 17AAG metabolite. An analogous series of demethylated and oxidized metabolites was also observed for the 17AG metabolite. Conclusions. Biliary excretion of 17AAG represents a major route of elimination, although most of the material excreted is in the form of metabolites. Bile of rats dosed with 17AAG contained a number of metabolites not previously identified in the plasma or urine of mice treated with 17AAG, but analogous to metabolites described in bile of rats treated with 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG, NSC 707545), another geldanamycin analogue undergoing preclinical evaluation in preparation for subsequent clinical trials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BILIARY tract
KW - DIGESTIVE organs
KW - EXCRETION
KW - HYDROLASES
KW - Ansamycin
KW - Biliary excretion
KW - Geldanamycin
KW - HSP90
N1 - Accession Number: 16821293; Musser, Steven M. 1 Egorin, Merrill J. 2,3,4,5 Zuhowski, Eleanor G. 2 Hamburger, Deborah R. 2 Parise, Robert A. 2 Covey, Joseph M. 6 White, Kevin D. 1 Eiseman, Julie L. 2,4; Affiliation: 1: Instrumentation and Biophysics Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA 2: Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, PA 15213, Pittsburgh, USA 3: Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, Pittsburgh, USA 4: Department of Pharmacology, University of Pittsburgh School of Medicine, PA 15213, Pittsburgh, USA 5: Room G27E Hillman Research Pavilion, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, PA 15213-1863, Pittsburgh, USA 6: Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, MD 20892, Bethesda, USA; Source Info: Aug2003, Vol. 52 Issue 2, p139; Subject Term: BILIARY tract; Subject Term: DIGESTIVE organs; Subject Term: EXCRETION; Subject Term: HYDROLASES; Author-Supplied Keyword: Ansamycin; Author-Supplied Keyword: Biliary excretion; Author-Supplied Keyword: Geldanamycin; Author-Supplied Keyword: HSP90; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shim, Joong Sup
AU - Kim, Jin Hee
AU - Cho, Hyun Young
AU - Yum, Young Na
AU - Kim, Seung Hee
AU - Park, Hyun-Ju
AU - Shim, Bum Sang
AU - Choi, Seung Hoon
AU - Kwon, Ho Jeong
T1 - Irreversible Inhibition of CD13/Aminopeptidase N by the Antiangiogenic Agent Curcumin
JO - Chemistry & Biology
JF - Chemistry & Biology
Y1 - 2003/08//
VL - 10
IS - 8
M3 - Article
SP - 695
SN - 10745521
AB - CD13/aminopeptidase N (APN) is a membrane-bound, zinc-dependent metalloproteinase that plays a key role in tumor invasion and angiogenesis. Here, we show that curcumin, a phenolic natural product, binds to APN and irreversibly inhibits its activity. The direct interaction between curcumin with APN was confirmed both in vitro and in vivo by surface plasmon resonance analysis and an APN-specific antibody competition assay, respectively. Moreover, curcumin and other known APN inhibitors strongly inhibited APN-positive tumor cell invasion and basic fibroblast growth factor-induced angiogenesis. However, curcumin did not inhibit the invasion of APN-negative tumor cells, suggesting that the antiinvasive activity of curcumin against tumor cells is attributable to the inhibition of APN. Taken together, our study revealed that curcumin is a novel irreversible inhibitor of APN that binds to curcumin resulting in inhibition of angiogenesis. [Copyright &y& Elsevier]
AB - Copyright of Chemistry & Biology is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINOPEPTIDASES
KW - METALLOPROTEINASES
KW - FIBROBLAST growth factors
KW - NEOVASCULARIZATION
N1 - Accession Number: 10696967; Shim, Joong Sup 1 Kim, Jin Hee 1 Cho, Hyun Young 2 Yum, Young Na 2 Kim, Seung Hee 2 Park, Hyun-Ju 3 Shim, Bum Sang 4 Choi, Seung Hoon 4 Kwon, Ho Jeong 1; Email Address: kwonhj@sejong.ac.kr; Affiliation: 1: Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul 143-747, South Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, South Korea 3: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea 4: College of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea; Source Info: Aug2003, Vol. 10 Issue 8, p695; Subject Term: AMINOPEPTIDASES; Subject Term: METALLOPROTEINASES; Subject Term: FIBROBLAST growth factors; Subject Term: NEOVASCULARIZATION; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S1074-5521(03)00169-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KLINMAN, D. M.
AU - CURRIE, D.
T1 - Hierarchical recognition of CpG motifs expressed by immunostimulatory oligodeoxynucleotides.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2003/08//
VL - 133
IS - 2
M3 - Article
SP - 227
EP - 232
PB - Wiley-Blackwell
SN - 00099104
AB - SUMMARY Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs trigger human PBMC to proliferate and secrete Ig, cytokines and chemokines. CpG ODN have entered clinical trials, and show promise as vaccine adjuvants, antiallergens, and for the treatment of infectious diseases and cancer. ODNs under consideration for human use vary in the sequence, number and location of the CpG motifs they contain. Yet little is known of the magnitude of the immune response elicited by these diverse ODNs, or the rules governing their interaction with immune cells. This work compares the proliferative, IgM, IL-6 and IP-10 response of PBMC from normal donors to a diverse panel of CpG ODNs. Results indicate that ODNs expressing 3–4 different CpG motifs are strongly stimulatory. The location of these motifs is important, with those at the 5′ end exerting the greatest influence on ODN activity. These findings provide a basis for the rational design of ODNs optimized for clinical use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - CHEMOKINES
KW - CLINICAL trials
KW - COMMUNICABLE diseases
KW - IMMUNE response
KW - CpG oligonucleotides
KW - cytokine
KW - human
KW - Ig
KW - immune response
KW - innate immunity
KW - PBMC
N1 - Accession Number: 10291522; KLINMAN, D. M. 1 CURRIE, D. 1; Affiliation: 1: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, USA; Source Info: Aug2003, Vol. 133 Issue 2, p227; Subject Term: CYTOKINES; Subject Term: CHEMOKINES; Subject Term: CLINICAL trials; Subject Term: COMMUNICABLE diseases; Subject Term: IMMUNE response; Author-Supplied Keyword: CpG oligonucleotides; Author-Supplied Keyword: cytokine; Author-Supplied Keyword: human; Author-Supplied Keyword: Ig; Author-Supplied Keyword: immune response; Author-Supplied Keyword: innate immunity; Author-Supplied Keyword: PBMC; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1365-2249.2003.02216.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woo, Emily Jane
AU - Burwen, Dale R.
AU - Gatumu, Sarah N.M.
AU - Ball, Robert
T1 - Extensive Limb Swelling after Immunization: Reports to the Vaccine Adverse Event Reporting System.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003/08//8/1/2003
VL - 37
IS - 3
M3 - Article
SP - 351
SN - 10584838
AB - Describes vaccine types involved in and the clinical characteristics of extensive limb swelling (ELS) cases reported to the Vaccine Adverse Event Reporting System (VAERS). Proportion of reports of ELS associated with a given vaccine; Reactions that involved signs of inflammation; Involvement of both the proximal and distal segments of the extremity.
KW - Vaccination -- Complications
KW - Inflammation
KW - Extremities (Anatomy)
N1 - Accession Number: 10590118; Woo, Emily Jane 1; Burwen, Dale R. 1; Gatumu, Sarah N.M. 1; Ball, Robert 1; Affiliations: 1: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland; Issue Info: 8/1/2003, Vol. 37 Issue 3, p351; Subject Term: Vaccination -- Complications; Subject Term: Inflammation; Subject Term: Extremities (Anatomy); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Johann Jr., Donald J.
AU - McGuigan, Michael D.
AU - Tomov, Stanimire
AU - Fusaro, Vincent A.
AU - Ross, Sally
AU - Conrads, Thomas P.
AU - Veenstra, Timothy D.
AU - Fishmand, David A.
AU - Whiteley, Gordon R.
AU - Petricoin, Emanuel F.
AU - Liotta, Lance A.
T1 - Novel approaches to visualization and data mining reveals diagnostic information in the low amplitude region of serum mass spectra from ovarian cancer patients.
JO - Disease Markers
JF - Disease Markers
Y1 - 2003/08//2003/2004
VL - 19
IS - 4/5
M3 - Article
SP - 197
EP - 207
PB - Hindawi Publishing Corporation
SN - 02780240
AB - The ability to identify patterns of diagnostic signatures in proteomic data generated by high throughput mass spectrometry (MS) based serum analysis has recently generated much excitement and interest from the scientific community. These data sets can be very large, with high-resolution MS instrumentation producing 1–2 million data points per sample. Approaches to analyze mass spectral data using unsupervised and supervised data mining operations would greatly benefit from tools that effectively allow for data reduction without losing important diagnostic information. In the past, investigators have proposed approaches where data reduction is performed by a priori "peak picking" and alignment/warping/smoothing components using rule-based signal-to-noise measurements. Unfortunately, while this type of system has been employed for gene microarray analysis, it is unclear whether it will be effective in the analysis of mass spectral data, which unlike microarray data, is comprised of continuous measurement operations. Moreover, it is unclear where true signal begins and noise ends. Therefore, we have developed an approach to MS data analysis using new types of data visualization and mining operations in which data reduction is accomplished by culling via the intensity of the peaks themselves instead of by location. Applying this new analysis method on a large study set of high resolution mass spectra from healthy and ovarian cancer patients, shows that all of the diagnostic information is contained within the very lowest amplitude regions of the mass spectra. This region can then be selected and studied to identify the exact location and amplitude of the diagnostic biomarkers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Disease Markers is the property of Hindawi Publishing Corporation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATA mining
KW - OVARIAN cancer
KW - MASS spectrometry
KW - BIOCHEMICAL markers
KW - DIAGNOSIS
KW - PROTEOMICS
KW - data visualization
KW - diagnosis
KW - ovarian cancer
KW - SELDI-TOF MS
N1 - Accession Number: 13834856; Johann Jr., Donald J. 1; Email Address: dj151o@nih.gov McGuigan, Michael D. 2 Tomov, Stanimire 2 Fusaro, Vincent A. 1 Ross, Sally 1 Conrads, Thomas P. 3 Veenstra, Timothy D. 3 Fishmand, David A. 4 Whiteley, Gordon R. 5 Petricoin, Emanuel F. 6 Liotta, Lance A. 1; Affiliation: 1: NCI-FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 2: Brookhaven National Laboratory, Information Technology Division, Upton, NY, USA 3: Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA 4: National Ovarian Cancer Early Detection Program, Northwestern University Medical School, Chicago, IL, USA 5: NCI-FDA Clinical Proteomics Program, Clinical Proteomics Reference Laboratory, SAIC Frederick, Gaithersburg, MD, USA 6: NCI-FDA Clinical Proteomics Program, Office of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: 2003/2004, Vol. 19 Issue 4/5, p197; Subject Term: DATA mining; Subject Term: OVARIAN cancer; Subject Term: MASS spectrometry; Subject Term: BIOCHEMICAL markers; Subject Term: DIAGNOSIS; Subject Term: PROTEOMICS; Author-Supplied Keyword: data visualization; Author-Supplied Keyword: diagnosis; Author-Supplied Keyword: ovarian cancer; Author-Supplied Keyword: SELDI-TOF MS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koken, Petra J.M.
AU - Piver, Warren T.
AU - Ye, Frank
AU - Elixhauser, Anne
AU - Olsen, Lola M.
AU - Portier, Christopher J.
T1 - Temperature, Air Pollution, and Hospitalization for Cardiovascular Diseases among Elderly People in Denver.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003/08//
VL - 111
IS - 10
M3 - Article
SP - 1312
EP - 1317
PB - Superintendent of Documents
SN - 00916765
AB - Daily measures of maximum temperature, particulate matter ≤ 10 µm in aerodynamic diameter (PM[sub 10]), and gaseous pollution (ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide) were collected in Denver, Colorado, in July and August between 1993 and 1997. We then compared these exposures with concurrent data on the number of daily hospital admissions for cardiovascular diseases in men and women > 65 years of age. Generalized linear models, assuming a Poisson error structure for the selected cardiovascular disease hospital admissions, were constructed to evaluate the associations with air pollution and temperature. After adjusting the admission data for yearly trends, day-of-week effects, ambient maximum temperature, and dew point temperature, we studied the associations of the pollutants in single-pollutant models with lag times of 0-4 days. The results suggest that O[sub 3] is associated with an increase in the risk of hospitalization for acute myocardial infarction, coronary atherosderosis, and pulmonary heart disease. SO[sub 2] appears to be related to increased hospital stays for cardiac dysrhythmias, and CO is significantly associated with congestive heart failure. No association was found between particulate matter or NO[sub 2] and any of the health outcomes. Males tend to have higher numbers of hospital admissions than do females for all of the selected cardiovascular diseases, except for congestive heart failure. Higher temperatures appear to be an important factor in increasing the frequency of hospitalization for acute myocardial infarction and congestive heart failure, and are associated with a decrease in the frequency of visits for coronary atherosclerosis and pulmonary heart disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gases
KW - Air pollution
KW - Denver (Colo.)
KW - Colorado
KW - United States
N1 - Accession Number: 10661510; Koken, Petra J.M. 1; Piver, Warren T. 1; Ye, Frank 1; Elixhauser, Anne 2; Olsen, Lola M. 3; Portier, Christopher J. 1; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; 2: Agency for Healthcare Research and Quality, Rockville, Maryland, USA; 3: National Aeronautics and Space Administration, Maryland, USA; Issue Info: Aug2003, Vol. 111 Issue 10, p1312; Thesaurus Term: Gases; Thesaurus Term: Air pollution; Subject: Denver (Colo.); Subject: Colorado; Subject: United States; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Perkins, Roger
AU - Hong Fang
AU - Tong, Weida
AU - Welsh, William J.
T1 - QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP METHODS: PERSPECTIVES ON DRUG DISCOVERY AND TOXICOLOGY.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2003/08//
VL - 22
IS - 8
M3 - Article
SP - 1666
EP - 1679
SN - 07307268
AB - Quantitative structure-activity relationships (QSARs) attempt to correlate chemical structure with activity using statistical approaches. The QSAR models are useful for various purposes including the prediction of activities of untested chemicals. Quantitative structure-activity relationships and other related approaches have attracted broad scientific interest, particularly in the pharmaceutical industry for drug discovery and in toxicology and environmental science for risk assessment. An assortment of new QSAR methods have been developed during the past decade, most of them focused on drug discovery. Besides advancing our fundamental knowledge of QSARs, these scientific efforts have stimulated their application in a wider range of disciplines, such as toxicology, where QSARs have not yet gained full appreciation. In this review, we attempt to summarize the status of QSAR with emphasis on illuminating the utility and limitations of QSAR technology. We will first review two-dimensional (2D) QSAR with a discussion of the availability and appropriate selection of molecular descriptors. We will then proceed to describe three-dimensional (3D) QSAR and key issues associated with this technology, then compare the relative suitability of 2D and 3D QSAR for different applications. Given the recent technological advances in biological research for rapid identification of drug targets, we mention several examples in which QSAR approaches are employed in conjunction with improved knowledge of the structure and function of the target receptor. The review will conclude by discussing statistical validation of QSAR models, a topic that has received sparse attention in recent years despite its critical importance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QSAR (Biochemistry)
KW - ENVIRONMENTAL toxicology
KW - ACUTE toxicity testing
KW - DRUG development
KW - PHARMACEUTICAL industry
KW - Chemoinformatics
KW - Chemometric
KW - Drug design
KW - Quantitative structure-activity relationship
KW - Toxicology
N1 - Accession Number: 15982726; Perkins, Roger 1; Email Address: rperkins@nctr.fda.gov Hong Fang 1 Tong, Weida 2 Welsh, William J. 3; Affiliation: 1: Logicon ROW Sciences, 3900 NCTR Road, MC 910, Jefferson, Arkansas 72079, USA 2: Center for Toxicoinformatics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas, 72079 3: Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, New Jersey 08854, USA; Source Info: Aug2003, Vol. 22 Issue 8, p1666; Subject Term: QSAR (Biochemistry); Subject Term: ENVIRONMENTAL toxicology; Subject Term: ACUTE toxicity testing; Subject Term: DRUG development; Subject Term: PHARMACEUTICAL industry; Author-Supplied Keyword: Chemoinformatics; Author-Supplied Keyword: Chemometric; Author-Supplied Keyword: Drug design; Author-Supplied Keyword: Quantitative structure-activity relationship; Author-Supplied Keyword: Toxicology; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 14p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tong, Weida
AU - Welsh, William J.
AU - Shi, Leming
AU - Fang, Hong
AU - Perkins, Roger
T1 - STRUCTURE-ACTIVITY RELATIONSHIP APPROACHES AND APPLICATIONS.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2003/08//
VL - 22
IS - 8
M3 - Article
SP - 1680
EP - 1695
SN - 07307268
AB - New techniques and software have enabled ubiquitous use of structure-activity relationships (SARs) in the pharmaceutical industry and toxicological sciences. We review the status of SAR technology by using examples to underscore the advances as well as the unique technical challenges. Applying SAR involves two steps: Characterization of the chemicals under investigation, and application of chemometric approaches to explore data patterns or to establish the relationships between structure and activity. We describe generally but not exhaustively the SAR methodologies popular use in toxicology, including representation of chemical structure, and chemometric techniques where models are both unsupervised and supervised. The utility of SAR technology is most evident when supervised methods are used to predict toxicity of untested chemicals based only on chemical structure. Such models can predict on both an ordinal scale (e.g., active vs inactive) or a continuous scale (e.g., median lethal dose [LD50] dose). The reader is also referred to a companion paper in this issue that discusses quantitative structure-activity relationship (QSAR) methods that have advanced markedly over the past decade. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STRUCTURE-activity relationships (Biochemistry)
KW - TOXICOLOGICAL chemistry
KW - CHEMICALS
KW - PHYSICAL & theoretical chemistry
KW - PHARMACEUTICAL industry
KW - Computational toxicology
KW - Predictive toxicology
KW - Structure-activity relationship
N1 - Accession Number: 15982728; Tong, Weida 1 Welsh, William J. 2 Shi, Leming 3 Fang, Hong 4 Perkins, Roger 4; Email Address: rperkins@nctr.fda.gov; Affiliation: 1: Center for Toxicoinformatics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079 2: Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry, 675 Hoes Lane, Piscataway, New Jersey 08854, USA 3: BASF Corporation, P.O. Box 400, Princeton, New Jersey 08543-0400, USA 4: Logicon ROW Sciences, 3900 NCTR Road, MC 910, Jefferson, Arkansas 72079, USA; Source Info: Aug2003, Vol. 22 Issue 8, p1680; Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: TOXICOLOGICAL chemistry; Subject Term: CHEMICALS; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: PHARMACEUTICAL industry; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Predictive toxicology; Author-Supplied Keyword: Structure-activity relationship; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 16p; Illustrations: 2 Color Photographs, 6 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoffman, Alexander F.
AU - Riegel, Arthur C.
AU - Lupica, Carl R.
T1 - Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus.
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
Y1 - 2003/08//
VL - 18
IS - 3
M3 - Article
SP - 524
EP - 534
PB - Wiley-Blackwell
SN - 0953816X
AB - Abstract The possible localization of cannabinoid (CB) receptors to glutamatergic and GABAergic synaptic terminals impinging upon GABAergic interneurons in the CA1 region of the rat hippocampus was examined using the electrophysiological measurement of neurotransmitter release in brain slices. Whereas activation of cannabinoid receptors via the application of the cannabinoid agonist WIN55,212-2 significantly and dose-dependently reduced evoked IPSCs recorded from interneurons possessing somata located in the stratum radiatum (S.R.) and stratum oriens (S.O.) lamellae, evoked glutamatergic EPSCs were unaffected in both neuronal populations. However, in agreement with previous reports, WIN55,212-2 significantly reduced EPSCs recorded from CA1 pyramidal neurons. Additional experiments confirmed that the effects of WIN55,212-2 on IPSCs were presynaptic and that they could be blocked by the CB1 receptor antagonist SR141716A. The involvement of endogenous cannabinoids in the presynaptic inhibition of GABA release was also examined in the interneurons and pyramidal cells using a depolarization-induced suppression of inhibition (DSI) paradigm. DSI was observed in CA1 pyramidal neurons under control conditions, and its incidence was greatly increased by the cholinergic agonist carbachol. However, DSI was not observed in the S.R. or S.O. interneuron populations, in either the presence or absence of carbachol. Whereas DSI was not present in these interneurons, the inhibitory inputs to these cells were modulated by the synthetic cannabinoid WIN55,212-2. These data support the hypothesis that cannabinoid receptors are located on inhibitory, but not excitatory, axon terminals impinging upon hippocampal interneurons, and that CA1 pyramidal neurons, and not interneurons, are capable of generating endogenous cannabinoids during prolonged states of depolarization. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GABA
KW - AMINO acid neurotransmitters
KW - CANNABINOIDS
KW - NEURONS
KW - CELLS
KW - electrophysiology
KW - glutamate
KW - interneurons
KW - marijuana
KW - rat
N1 - Accession Number: 10543502; Hoffman, Alexander F. 1 Riegel, Arthur C. 1 Lupica, Carl R. 1; Affiliation: 1: Cellular Neurobiology Research Branch and Cellular Neurophysiology Unit, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA; Source Info: Aug2003, Vol. 18 Issue 3, p524; Subject Term: GABA; Subject Term: AMINO acid neurotransmitters; Subject Term: CANNABINOIDS; Subject Term: NEURONS; Subject Term: CELLS; Author-Supplied Keyword: electrophysiology; Author-Supplied Keyword: glutamate; Author-Supplied Keyword: interneurons; Author-Supplied Keyword: marijuana; Author-Supplied Keyword: rat; Number of Pages: 0p; Document Type: Article
L3 - 10.1046/j.1460-9568.2003.02773.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garthright, W.E.
AU - Blodgett, R.J.
T1 - FDA's preferred MPN methods for standard, large or unusual tests, with a spreadsheet
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2003/08//
VL - 20
IS - 4
M3 - Article
SP - 439
SN - 07400020
AB - The US Food and Drug Administration (FDA) presents its preferred methods for statistical interpretation of serial dilution tests for microbes in the Bacteriological Analytical Manual (BAM) of the FDA and the AOAC. This article explains why the particular methods in the manual were selected and describes the adjustments chosen to create a new, flexible method for calculating most probable numbers (MPNs), confidence intervals, and measures of improbability for up to 18 dilutions and up to 1020 tubes per dilution. The methods have been put into a spreadsheet for easy use, and are offered free in the interest of promoting the microbial safety of food and water. The FDA prefers the MPN, not adjusted for bias, for its point estimate of concentration, with the improbability standards and confidence intervals of De Man for standard three-dilution tables with up to 10 tubes per dilution. For large or unusual test designs, the FDA also prefers the MPN but with a new improbability index and the confidence intervals of Haldane. Some other methods in recent literature are discussed briefly, and reasons are given why they are not preferred. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIA
KW - UNITED States
KW - Fermentation tubes
KW - Microbial concentration
KW - Most probable number
KW - MPN
KW - Serial dilution
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 9496087; Garthright, W.E. 1 Blodgett, R.J.; Email Address: robert.blodgett@cfsan.fda.gov; Affiliation: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Mathematics, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Source Info: Aug2003, Vol. 20 Issue 4, p439; Subject Term: BACTERIA; Subject Term: UNITED States; Author-Supplied Keyword: Fermentation tubes; Author-Supplied Keyword: Microbial concentration; Author-Supplied Keyword: Most probable number; Author-Supplied Keyword: MPN; Author-Supplied Keyword: Serial dilution; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0740-0020(02)00144-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106729673
T1 - AHRQ: a tradition of evidence: federal agency carries a rich history of involvement in today's evidence-based medicine movement, focusing on the 'evidence inside' healthcare IT.
AU - Clancy CM
Y1 - 2003/08//
N1 - Accession Number: 106729673. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Computer/Information Science; Health Services Administration; USA. NLM UID: 9423239.
KW - United States Agency for Healthcare Research and Quality
KW - Information Resources
KW - Research -- Utilization
SP - 26
EP - 29
JO - Health Management Technology
JF - Health Management Technology
JA - HEALTH MANAGE TECHNOL
VL - 24
IS - 8
CY - Sarasota, Florida
PB - NP Communications, LLC
SN - 1074-4770
AD - Director, Agency for Healthcare Research and Quality, Rockville, Md
U2 - PMID: 12924057.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Cox, Morgan
AU - Hoover, Mark D.
AU - Grivaud, Liliane
AU - Johnson, Michelle
AU - Newton, Geoger J.
T1 - STANDARDS FOR MEASURING AIRBORNE RADIOACTIVITY.
JO - Health Physics
JF - Health Physics
Y1 - 2003/08//
VL - 85
IS - 2
M3 - Letter
SP - 236
EP - 241
SN - 00179078
AB - Describes the standards organizations for airborne radioactivity in the U.S. Global organization that prepares and publishes international standards for electrical, electronic and related technologies; Air monitoring standards according to the location of application and type of airborne activity.
KW - Radioactivity
KW - Standards
KW - United States
N1 - Accession Number: 10829781; Cox, Morgan; Hoover, Mark D. 1; Grivaud, Liliane 2; Johnson, Michelle 3; Newton, Geoger J.; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; 2: Institut de Radioprotection et Surete Nucleaire, IRSN/DPEA/SERAC, France; 3: Pacific Nortwest National Laboratory; Issue Info: Aug2003, Vol. 85 Issue 2, p236; Thesaurus Term: Radioactivity; Subject Term: Standards; Subject: United States; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kim, Kye Young
AU - Lee, June Woo
AU - Ahn, Byeong Woo
AU - Ryu, Pan Dong
AU - Nam, Myeong Jin
T1 - Loss of endogenous TGF-β effect induces mouse hepatoma malignancy by correlation with cyclooxygenase-2 and VEGF
JO - Hepatology Research
JF - Hepatology Research
Y1 - 2003/08//
VL - 26
IS - 4
M3 - Article
SP - 302
SN - 13866346
AB - The relation between transforming growth factor-β (TGF-β) and cyclooxygenase (COX) in hepatoma malignancy is not understood yet. To investigate regulation mechanism of endogenous TGF-β on hepatoma, we established MH129F mouse hepatoma cell overexpressing the cytoplasmic domain of type II TGF-β receptor (TRII). MH129F cell apoptosis was elevated almost 20% after 5 ng/ml TGF-β1 treatment. However, soluble TRII-overexpressing cells (MH129F/TRIIs) did not show any change of growth pattern after TGF-β1 treatment because MH129F/TRIIs cells blocked the growth inhibitory effect of TGF-β1. In MH129F/TRIIs cells, expression of cycooxygenase-2 (COX-2) and bcl-2 was remarkably elevated, and then enhancement of COX-2 mediated induction of prostaglandin E2 (PGE2) production up to 7-fold. Especially, vascular endothelial growth factor (VEGF) expression was regulated by COX-2 in MH129F/TRIIs cells, which were inhibited endogenous TGF-β response. Implantation of 5×106 MH129F/TRIIs cells into nude mice showed the significantly enhanced tumor formation, and intensity of COX-2 expression was slightly higher in MH129F/TRIIs tumor section than control. Moreover, a strong antitumor response was observed in MH129F/TRIIs-bearing mice that were treated with a specific COX-2 inhibitor, celecoxib. Therefore, we suggest that COX-2 mediate the tumorigenicity of hepatoma cells blocking endogenous TGF-β effect via VEGF regulation. [Copyright &y& Elsevier]
AB - Copyright of Hepatology Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFORMING growth factors-beta
KW - TRANSFORMING growth factors
KW - CYCLOOXYGENASES
KW - HEPATOMA
KW - APOPTOSIS
KW - PROSTAGLANDINS
KW - Celecoxib
KW - CM, conditioned medium
KW - COX, cyclooxygenase
KW - Cyclooxygenase (COX)
KW - ELISA, enzyme linked immunosorbent assay
KW - Hepatoma
KW - PGE2, prostaglandin E2
KW - TGF-β, transforming growth factor-β
KW - Transforming growth factor-β (TGF-β)
KW - TRII, type II TGF-β receptor
KW - TRIIs, soluble type II TGF-β receptor
KW - Vascular endothelial growth factor (VEGF)
KW - VEGF, vascular endothelial growth factor
N1 - Accession Number: 10745105; Kim, Kye Young 1; Email Address: anne8073@kebi.com Lee, June Woo 1 Ahn, Byeong Woo 2 Ryu, Pan Dong 3 Nam, Myeong Jin 1; Affiliation: 1: Division of Cardiovascular Disease, Department of Biomedical Sciences, National Institute of Health, #5 Nokbun-dong, Eunpyung-gu, Seoul 122-701, South Korea 2: Division of Histopathology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, South Korea 3: Laboratory of Pharmacology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, South Korea; Source Info: Aug2003, Vol. 26 Issue 4, p302; Subject Term: TRANSFORMING growth factors-beta; Subject Term: TRANSFORMING growth factors; Subject Term: CYCLOOXYGENASES; Subject Term: HEPATOMA; Subject Term: APOPTOSIS; Subject Term: PROSTAGLANDINS; Author-Supplied Keyword: Celecoxib; Author-Supplied Keyword: CM, conditioned medium; Author-Supplied Keyword: COX, cyclooxygenase; Author-Supplied Keyword: Cyclooxygenase (COX); Author-Supplied Keyword: ELISA, enzyme linked immunosorbent assay; Author-Supplied Keyword: Hepatoma; Author-Supplied Keyword: PGE2, prostaglandin E2; Author-Supplied Keyword: TGF-β, transforming growth factor-β; Author-Supplied Keyword: Transforming growth factor-β (TGF-β); Author-Supplied Keyword: TRII, type II TGF-β receptor; Author-Supplied Keyword: TRIIs, soluble type II TGF-β receptor; Author-Supplied Keyword: Vascular endothelial growth factor (VEGF); Author-Supplied Keyword: VEGF, vascular endothelial growth factor; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S1386-6346(03)00155-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wassell, James T.
T1 - Occupational Injury Risk Assessment: An Unintended and Unanticipated Consequence of the Red Book.
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2003/08//
VL - 9
IS - 5
M3 - Article
SP - 1383
EP - 1390
SN - 10807039
AB - The authors of the National Research Council's report Risk Assessment in the Federal Government: Managing the Process, called the "Red Book," included reference to "other hazards" and "other Federal programs to reduce health risks." With the focus on chemicals and cancer, the authors probably never considered that the risk assessment and risk management processes that they debated would find application in evaluating traumatic workplace injuries to reduce disability and death on the job. The severity of the consequences of workplace hazards, which are mostly immediate and do not have the long latency associated with cancer, is a significant public health risk. Quantitative risk assessment, to determine the incremental effects of additional exposure, also plays an important role in the workplace. This paper discusses these issues and reviews some of the important papers that explain occupational injury risk assessment and its applicability to risk management. Key Words: workplace hazards; traumatic; Red Book; National Research Council; fatal injury; occupations; industries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Ecological Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - RISK management in business
KW - INDUSTRIAL safety
KW - WORK-related injuries
KW - UNITED States
KW - NATIONAL Research Council (U.S.)
N1 - Accession Number: 11917503; Wassell, James T. 1; Email Address: jtw2@cdc.gov; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, West Virginia, USA; Source Info: Aug2003, Vol. 9 Issue 5, p1383; Subject Term: RISK assessment; Subject Term: RISK management in business; Subject Term: INDUSTRIAL safety; Subject Term: WORK-related injuries; Subject Term: UNITED States; Company/Entity: NATIONAL Research Council (U.S.); Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10807030390240427
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11917503&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
AU - Laib, Andres
T1 - The Dependence of Ultrasonic Backscatter on Trabecular Thickness in Human Calcaneus: Theoretical and Experimental Results.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2003/08//
VL - 50
IS - 8
M3 - Article
SP - 979
EP - 986
SN - 08853010
AB - Trabecular thickness within cancellous bone is an important determinant of osteoporotic fracture risk. Non-invasive assessment of trabecular thickness potentially could yield useful diagnostic information. Faran's theory of elastic scattering from a cylindrical object immersed in a fluid has been used to predict the dependence of ultrasonic backscatter on trabecular thickness. The theory predicts that, in the range of morphological and material properties expected for trabecular bone, the backscatter coefficient at 500 kHz should be approximately proportional to trabecular thickness to the power of 2.9. Experimental measurements of backscatter coefficient were performed on 43 human calcaneus samples in vitro. Mean trabecular thicknesses on the 43 samples were assessed using micro computed tomography (CT). A power law fit to the data showed that the backscatter coefficient empirically varied as trabecular thickness to the 2.8 power. The 95% confidence interval for this exponent was 1.7 to 3.9. The square of the correlation coefficient for the linear regression to the log transformed data was 0.40. This suggests that 40% of variations in backscatter may be attributed to variations in trabecular thickness. These results reinforce previous studies that offered validation for the Faran cylinder model for prediction of scattering properties of cancellous bones and provide added evidence for the potential diagnostic utility of the backscatter measurement. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONICS in medicine
KW - FRACTURES
N1 - Accession Number: 10791561; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov Laib, Andres 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, MD 2: SCANCO Medical AG, Switzerland; Source Info: Aug2003, Vol. 50 Issue 8, p979; Subject Term: ULTRASONICS in medicine; Subject Term: FRACTURES; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jang, S.I.
AU - Pae, H.O.
AU - Choi, B.M.
AU - Oh, G.S.
AU - Jeong, S.
AU - Lee, H.J.
AU - Kim, H.Y.
AU - Kang, K.J.
AU - Yun, Y.G.
AU - Kim, Y.C.
AU - Chung, H.T.
T1 - Salidroside from Rhodiola sachalinensis Protects Neuronal PC12 Cells Against Cytotoxicity Induced by Amyloid-β.
JO - Immunopharmacology & Immunotoxicology
JF - Immunopharmacology & Immunotoxicology
Y1 - 2003/08//
VL - 25
IS - 3
M3 - Article
SP - 295
PB - Taylor & Francis Ltd
SN - 08923973
AB - The amyloid β-peptide (Aβ)-induced oxidative stress is a well-established pathway of neuronal cell death in Alzheimer's disease (AD). Salidroside, one of the major compounds from the roots of Rhodiola species (Crassulaceae), was investigated in vitro for its cytoprotection against Aβ-induced toxicity on rat neuronal PC12 cells. Salidroside significantly reduced Aβ-induced cytotoxicity in a dose-dependent manner. Salidroside also reduced Aβ-mediated intracellular accumulation of reactive oxygen species and malondialdehyde (MDA), a product of lipid peroxides, by preventing Aβ-induced decline of antioxidant enzyme activities. These results suggest that salidroside protects neuronal PC12 cells from Aβ-induced cytotoxicity via its antioxidant pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunopharmacology & Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMYLOID beta-protein
KW - STRESS (Physiology)
KW - CELL death
KW - ALZHEIMER'S disease
N1 - Accession Number: 10737508; Jang, S.I. 1 Pae, H.O. 2 Choi, B.M. 2 Oh, G.S. 2 Jeong, S. 2 Lee, H.J. 3 Kim, H.Y. 3 Kang, K.J. 3 Yun, Y.G. 2 Kim, Y.C. 2 Chung, H.T. 1,2; Email Address: htchung@wonkwang.ac.kr; Affiliation: 1: Department of Microbiology and Immunology, Wonkwang Univesity School of Medicine 2: Medicinal Resources Research Center of Wonkwang 3: Department of Food Evaluation, Korea Food and Drug Administration; Source Info: Aug2003, Vol. 25 Issue 3, p295; Subject Term: AMYLOID beta-protein; Subject Term: STRESS (Physiology); Subject Term: CELL death; Subject Term: ALZHEIMER'S disease; Number of Pages: 10p; Document Type: Article
L3 - 10.1081/IPH-120024498
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen, C.T.
AU - Peden-Adams, M.M.
AU - EuDaly, J.
AU - Keil, D.E.
T1 - Subchronic Exposure to Ellagic Acid Impairs Cytotoxic T-Cell Function and Suppresses Humoral Immunity in Mice.
JO - Immunopharmacology & Immunotoxicology
JF - Immunopharmacology & Immunotoxicology
Y1 - 2003/08//
VL - 25
IS - 3
M3 - Article
SP - 409
PB - Taylor & Francis Ltd
SN - 08923973
AB - Ellagic acid (EA) is present in a variety of foods such as grapes, strawberries, raspberries, and nuts. It is a dietary plant phenol that has been shown to inhibit oxidative stress and chemical carcinogenesis. Although several studies have examined the protective mechanisms of dietary EA including the induction of detoxifying enzymes, regulation of cell cycle, chelation of nickel, and prevention of DNA methylation, none have addressed the role of EA in immunological surveillance. This study investigates the status of immune function in B6C3F1 mice exposed continuously to EA in drinking water at 0.5, 1.0, or 2.0 mg/kg/day for 28 days. Although this range of exposure is above the estimated human daily intake (≈940 µg/day for 70 kg person or 13.4 µg/kg/day), these levels would not be unreasonable if EA were used as a dietary supplement or as a chemotherapeutic agent. Previous reports have demonstrated the anticarcinogenic effects of EA at levels 10- to 250-fold greater than those applied in this study. Immunological parameters assessed included natural killer (NK) cell activity, cytotoxic T lymphocyte (CTL) activity, IgM antibody plaque forming cell (PFC) response, thymus, spleen, kidney, and liver mass, and total cellularity for the thymus and spleen. Subchronic exposure to EA for 28 days in drinking water caused significant suppression of specific IgM antibody responses in the 2.0 mg/kg EA treatment group and suppressed cytotoxic T-cell function in the 0.5 and 1.0 mg/kg EA treatment groups. All other immunological parameters were within normal ranges. Kidney and liver mass were not altered after treatment with EA. The results from this study indicate that EA suppressed both IgM antibody responses and CTLs. These observations suggest important implications on human health should EA be prescribed as a chemotherapeutic agent or a preventative dietary supplement for cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunopharmacology & Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOLS
KW - T cells
KW - IMMUNITY
KW - MICE
N1 - Accession Number: 10737499; Allen, C.T. 1 Peden-Adams, M.M. 1,2,3 EuDaly, J. 1 Keil, D.E. 1,4; Email Address: dkeil@cdc.gov; Affiliation: 1: Department of Health Professions 2: Department of Medicine⁄Rheumatology and Immunology 3: Department of Marine Biomedicine and Environmental Science Center, Medical University of South Carolina 4: National Institute of Occupational Safety and Health; Source Info: Aug2003, Vol. 25 Issue 3, p409; Subject Term: PHENOLS; Subject Term: T cells; Subject Term: IMMUNITY; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1081/IPH-120024508
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chapman, L.J.
AU - Taveira, A.D.
AU - Josefsson, K.G.
AU - Hard, D.
T1 - Evaluation of an Occupational Injury Intervention Among Wisconsin Dairy Farmers.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2003/08//
VL - 9
IS - 3
M3 - Article
SP - 197
EP - 209
SN - 10747583
AB - Evaluates an intervention to decrease dairy farming injury rates in Wisconsin. Improvement of information flow to operation managers; Adoption of safer production practices; Supplement of injury control efforts.
KW - Industrial safety
KW - Dairy farming
KW - Wisconsin
KW - United States
N1 - Accession Number: 10783447; Chapman, L.J. 1; Email Address: ljchapman@facstaff.wisc.edu; Taveira, A.D. 2; Josefsson, K.G. 1; Hard, D. 3; Affiliations: 1: Department of Biological Systems Engineering, University of Wisconsin; 2: Occupational and Environmental Safety and Health Department, University of Wisconsin; 3: Agricultural Safety and Health Scientist, U.S. Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; Issue Info: Aug2003, Vol. 9 Issue 3, p197; Thesaurus Term: Industrial safety; Subject Term: Dairy farming; Subject: Wisconsin; Subject: United States; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - J.S. Brazier
AU - V. Hall
AU - T.E. Morris
AU - M. Gal
AU - B.I. Duerden
T1 - Antibiotic susceptibilities of Gram-positive anaerobic cocci: results of a sentinel study in England and Wales.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2003/08//
VL - 52
IS - 2
M3 - Article
SP - 224
SN - 03057453
N1 - Accession Number: 11162778; J.S. Brazier 1; V. Hall 1; T.E. Morris 1; M. Gal 1; B.I. Duerden 1; Affiliations: 1: Anaerobe Reference Laboratory, National Public Health Service Wales, Microbiology Cardiff, University Hospital of Wales, Cardiff CF14 4XW, UK; Issue Info: Aug2003, Vol. 52 Issue 2, p224; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106775610
T1 - Cultural orientation and coping with perceived discrimination among African American youth.
AU - Scott LD Jr.
Y1 - 2003/08//
N1 - Accession Number: 106775610. Language: English. Entry Date: 20040910. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Self-Report Coping Scale (SRCS) (Causey and Dubow); Cultural Questionnaire for Children (CQC) (Jagers and Mock). NLM UID: 7904302.
KW - Blacks -- In Adolescence
KW - Coping -- In Adolescence
KW - Culture
KW - Racism
KW - Adolescence
KW - Affect -- In Adolescence
KW - Alabama
KW - Coefficient Alpha
KW - Construct Validity
KW - Correlation Coefficient
KW - Criterion-Related Validity
KW - Factor Analysis
KW - Female
KW - Individuality -- In Adolescence
KW - Male
KW - Ohio
KW - One-Way Analysis of Variance
KW - Optimism -- In Adolescence
KW - Questionnaires
KW - Religion and Religions -- In Adolescence
KW - Scales
KW - Spirituality -- In Adolescence
KW - Summated Rating Scaling
KW - T-Tests
KW - Vignettes
KW - Human
SP - 235
EP - 256
JO - Journal of Black Psychology
JF - Journal of Black Psychology
JA - J BLACK PSYCHOL
VL - 29
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - This study sought to explore whether the resonance of certain orientations and dimensions asserted to be distinctive of Black culture (affect, communalism, and spirituality) and mainstream American culture (competition, effort optimism, and individualism) wer related to the strategies used by African American youth to cope with perceived discrimination. Participants wer 120 African American youth from two geographical regions in the United States (northern Alabama, n = 71; central Ohio, n = 49). The findings suggested that orientations and corresponding dimensions of Black culture and mainstream American culture might evidence varying degrees of resonance among African American youth from disparate social-environmental contexts. The findings also indicated that spirituality and effort optimism wer related to greater use of self-reliance/problemsolving coping strategies, whereas communalism was related to lower use of externalizing coping strategies. The implications of cultural orientation for the adjustment and psychological functioning of African American youth in the face of multiple racial contingencies are discussed.
SN - 0095-7984
AD - Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, Campus Box 1093, One Brookings Dr, St Louis, MO 63130; lscott@gwbmail.wustl.edu
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DP - EBSCOhost
DB - rzh
ER -
ID - 89447968
T1 - Functional imaging in phase I studies: decorations or decision making?
AU - Collins, Jerry M.
Y1 - 2003/08//8/1/2003
N1 - Accession Number: 89447968. Language: English. Entry Date: 20040709. Revision Date: 20161128. Publication Type: editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Functional Living Index: Cancer (FLIC) (Schipper et al). NLM UID: 8309333.
KW - Neoplasms -- Drug Therapy
KW - Antineoplastic Agents -- Pharmacodynamics
KW - Stilbenes
KW - Clinical Trials
KW - Magnetic Resonance Imaging
KW - Tomography, Emission-Computed
KW - Antineoplastic Agents -- Pharmacokinetics
KW - Neoplasms -- Blood Supply
KW - Decision Making
KW - Animals
KW - Rats
KW - Clinical Assessment Tools
SP - 2807
EP - 2809
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 21
IS - 15
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - Laboratory of Clinical Pharmacology, United States Food and Drug Administration, Rockville, MD
U2 - PMID: 12807933.
DO - 10.1200/JCO.2003.05.100
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vincentelli, J.
AU - Luccioni, A.
AU - Devictor, B.
AU - Dussol, B.
AU - Lechevallier, E.
AU - Bertault-Peres, P.
AU - Coulange, C.
AU - Berland, Y.
AU - Penot Ragon, C.
T1 - Comparative study on two kidney graft rinsing and preservation solutions in terms of the post-transplantation risk of delayed graft function and cost.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2003/08//
VL - 28
IS - 4
M3 - Article
SP - 273
EP - 277
PB - Wiley-Blackwell
SN - 02694727
AB - Summary Objective: To determine whether Belzer solution (Viaspan® , Bristol-Myers Squibb, Brussels, Belgium), which is more expensive than Eurocollins solution, was better at preventing delayed graft function (DGF) and whether it was cost-effective as it could potentially reduce post-transplantation complications. Method: The risk of occurrence of complications associated with the use of these two rinsing and preserving solutions was estimated from a survey of 106 patients undergoing renal transplantation between 1 January 1993 and 31 March 1998. Both efficacy and adverse outcomes were recorded along with the costs directly associated with the transplantation procedure in the hospital setting: hospitalization, rinsing and preserving solutions, medical and technical interventions and diagnostic tests. Results: For the 45 kidney grafts rinsed and preserved with Eurocollins (strategy S1: n 1 = 45) the cost/graft was estimated at 40 €. With Viaspan® (strategy S2: n 2 = 61) the corresponding cost/graft was 424 €. Logistic regression analysis showed that Viaspan® was better than Eurocollins solution (e β = 0·437; P = 0·05) in preventing DGF. Overall, S2 was less expensive than S1 , from the hospital's perspective. The mean difference per patient was 278 €, which amounts to a saving of 2% of the total cost per renal transplantation. For rinsing and preserving kidney grafts Belzer solution is therefore preferable to Eurocollins solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KIDNEY transplants
KW - GRAFT versus host reaction
KW - MEDICAL care costs
KW - SOLUTIONS (Pharmacy)
KW - acute tubular necrosis
KW - cost minimization study
KW - kidney graft
KW - logistic regression
KW - rinsing and preservation solution
N1 - Accession Number: 10535755; Vincentelli, J. 1 Luccioni, A. 2 Devictor, B. 3 Dussol, B. 4 Lechevallier, E. 2 Bertault-Peres, P. 1 Coulange, C. 2 Berland, Y. 4 Penot Ragon, C. 1; Affiliation: 1: Department of Pharmacy, 2: Department of Renal Transplantation, CHU-Sud, 3: Public Health Service, Université de la Méditerranée and 4: Department of Nephrology, CHU-Sud, Marseille, France; Source Info: Aug2003, Vol. 28 Issue 4, p273; Subject Term: KIDNEY transplants; Subject Term: GRAFT versus host reaction; Subject Term: MEDICAL care costs; Subject Term: SOLUTIONS (Pharmacy); Author-Supplied Keyword: acute tubular necrosis; Author-Supplied Keyword: cost minimization study; Author-Supplied Keyword: kidney graft; Author-Supplied Keyword: logistic regression; Author-Supplied Keyword: rinsing and preservation solution; Number of Pages: 5p; Document Type: Article
L3 - 10.1046/j.1365-2710.2003.00489.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fleischman, G.J.
AU - Napier, C.L.
AU - Stewart, D.
AU - Palumbo, S.A.
T1 - Effect of Temperature on the Growth Response of Salmonella Enteritidis Inoculated onto the Vitelline Membranes of Fresh Eggs.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/08//
VL - 66
IS - 8
M3 - Article
SP - 1368
EP - 1373
SN - 0362028X
AB - The growth response of Salmonella Enteritidis (SE) on the vitelline membrane in vitro was studied with the use of a special tube devised specifically for the inoculation of SE onto the vitelline membrane and for the sampling of the yolk near the inoculation site. This latter ability allowed the detection of the movement of SE into the yolk. The growth of SE on the membrane was compared with that of SE inoculated into yolk and albumen in vitro and in ovo in fresh in-shell eggs. The incubation time was 2 days, and the incubation temperatures were 4, 8, 15, 27, and 37°C. Comparison of the results obtained for in vitro growth showed that at 4, 8, and 15°C, SE behaved as if it were in the albumen, with its numbers decreasing over time. At 27 and 37°C, SE grew as if it were in yolk, with a maximum increase of 4.5 log CFU after 2 days at 37°C. In no experiments involving growth on the vitelline membrane did SE appear in the yolk. Comparisons between in vitro and in ovo growth responses of SE in yolk and albumen indicate that SE growth on the membrane parallels that in the in-shell egg. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Temperature
KW - Eggs
KW - Salmonella enteritidis
KW - Zona pellucida
N1 - Accession Number: 10908543; Fleischman, G.J. 1; Email Address: gfleisch@cfsan.fda.gov; Napier, C.L. 1; Stewart, D. 2; Palumbo, S.A.; Affiliations: 1: U.S. Food and Drug Administration; 2: Illinois Institute of Technology, National Center for Food Safety and Technology; Issue Info: Aug2003, Vol. 66 Issue 8, p1368; Thesaurus Term: Temperature; Thesaurus Term: Eggs; Subject Term: Salmonella enteritidis; Subject Term: Zona pellucida; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reddy, N.R.
AU - Solomon, H.M.
AU - Tetzloff, R.C.
AU - Rhodehamel, E.J.
T1 - Inactivation of Clostridium botulinum Type A Spores by High-Pressure Processing at Elevated Temperatures.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/08//
VL - 66
IS - 8
M3 - Article
SP - 1402
EP - 1407
SN - 0362028X
AB - The effects of high-pressure treatments at various temperature-time combinations on the inactivation of spores of Clostridium botulinum type A strains 62-A and BS-A in phosphate buffer (0.067 M, pH 7.0) and in a crabmeat blend were investigated. The log unit reduction of strain 62-A spores increased significantly as the processing pressure increased from 417 to 827 MPa (from 60,000 to 120,000 lb/in²) at 75°C. The reduction of BS-A and 62-A spores in either medium increased as processing temperatures increased from 60 to 75°C and processing times increased from 5 to 15 or 20 min at a maximum pressure of 827 MPa. Approximately 2- and 3-log reductions of BS-A and 62-A spores, respectively, in phosphate buffer were obtained at the maximum pressure-maximum temperature combination of 827 MPa and 75°C for a processing time of 20 min. Processing for 15 min at the maximum pressure-maximum temperature combination resulted in maximum reductions of 3.2 and 2.7 log units for BS-A and 62-A spores, respectively, in the crabmeat blend. Results obtained in this study indicate that the crabmeat blend did not protect BS-A and 62-A spores against inactivation by high-pressure processing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Temperature
KW - Food handling
KW - Clostridium botulinum
N1 - Accession Number: 10908548; Reddy, N.R. 1; Email Address: rukma.reddy@cfsan.fda.gov; Solomon, H.M. 2; Tetzloff, R.C. 3; Rhodehamel, E.J. 4; Affiliations: 1: U.S. Food and Drug Administration; 2: Division of Microbiological Studies, U.S. Food and Drug Administration; 3: National Center for Food Safety and Technology, Illinois Institute of Technmology; 4: Cryovac, Sealed Air Corp.; Issue Info: Aug2003, Vol. 66 Issue 8, p1402; Thesaurus Term: Foodborne diseases; Thesaurus Term: Temperature; Thesaurus Term: Food handling; Subject Term: Clostridium botulinum; Number of Pages: 6p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yoon, K.S.
AU - Burnette, C.N.
AU - Whiting, R.C.
T1 - Effects of pH and Agitation on the Growth of Listeria monocytogenes Scott A in Brain Heart Infusion Broth Containing Combined Potassium Lactate and Sodium Diacetate during Storage at 4 or 10°C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/08//
VL - 66
IS - 8
M3 - Article
SP - 1469
EP - 1473
SN - 0362028X
AB - The objective of this study was to compare the effects of pH on the growth kinetics of Listeria monocytogenes Scott A in static and agitated broths stored at 4 and 10°C with and without a combination of 1.85% potassium lactate (PL) and 0.13% sodium diacetate (SDA) (3.3% of a 60% commercial solution, PURASAL P Opti.Form 4). The pH of brain heart infusion broth without (control) or with 1.85% PL + 0.13% SDA was adjusted to 5.5, 6.0, 6.5, and 7.5. L. monocytogenes Scott A was inoculated (at 10² CFU/ml) into pH-adjusted broth, which was stored at 4 or 10°C with or without agitation. At pH 5.5, a listeriostatic effect was observed for the broth containing 1.85% PL + 0.13% SDA at 4 and 10°C both with and without agitation. At pH 6.0, 1.85% PL + 0.13% SDA fully controlled the growth of L. monocytogenes Scott A in static broth at 4°C for up to 20 days and significantly slowed the growth of the pathogen in agitated broth. At 10°C, the growth of L. monocytogenes Scott A was significantly reduced by 1.85% PL + 0.13% SDA in agitated and unagitated broths. At pH 6.5, 1.85% PL + 0.13% SDA significantly suppressed the growth of L. monocytogenes Scott A at both 4°C (P < 0.001) and 10°C (P < 0.01). At pH 7.5, 1.85% PL + 0.13% SDA had a limited effect on the growth of L. monocytogenes Scott A in broth stored at 4 and 10°C. At 4°C, agitation decreased the lag time and increased the growth rate of L. monocytogenes Scott A at all tested phs. A similar but less obvious trend was observed for broths stored at 10°C. These results indicate that lactate-diacetate combinations effectively acted with low pH and temperature to inhibit the growth of L. monocytogenes Scott A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Hydrogen-ion concentration
KW - Listeria monocytogenes
N1 - Accession Number: 10908561; Yoon, K.S. 1; Email Address: ksyoon@mail.umes.edu; Burnette, C.N. 1; Whiting, R.C. 2; Affiliations: 1: Department of Human Ecology, University of Maryland Eastern Shore; 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration; Issue Info: Aug2003, Vol. 66 Issue 8, p1469; Thesaurus Term: Foodborne diseases; Thesaurus Term: Hydrogen-ion concentration; Subject Term: Listeria monocytogenes; Number of Pages: 5p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Bleckwenn, Nicole A.
AU - Shiloach, Joseph
AU - Taffs, Rolf
AU - Merchlinsky, Michael
AU - Eller, Nancy
AU - Mikolajczyk, Malgorzata G.
AU - Clanton, David J.
AU - Monath, Thomas
AU - Weltzi, Richard A.
AU - Scott, Dorothy E.
AU - Golding, Hana
T1 - Development of a Novel Vaccinia-Neutralization Assay Based on Reporter-Gene Expression.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2003/08//8/1/2003
VL - 188
IS - 3
M3 - Article
SP - 440
SN - 00221899
AB - In anticipation of large-scale smallpox vaccination, clinical trials of new vaccine candidates with improved safety profiles, and new vaccinia immune globulin (VIG) products, there is an immediate need to develop new assays to measure vaccinia-specific immune responses. The classical assay to measure vaccinia neutralization, the plaque-reduction neutralization test (PRNT), is slow, labor intensive, and difficult to validate and transfer. Here we describe the development of a novel vaccinia-neutralization assay based on the expression of a reporter gene, β-galactosidase (β-Gal). Using a previously constructed vaccinia-β-Gal recombinant virus, vSC56, we developed a neutralization assay that is rapid, sensitive, and reproducible. The readout is automated. We show that the neutralizing titers, ID[sub 50], for several VIG products measured by our assay were similar to those obtained by PRNTs. A new Food and Drug Administration VIG standard was established for distribution to other laboratories. The new assay will serve as an important tool both for preclinical and clinical trials of new smallpox vaccines and for evaluation of therapeutic agents to treat vaccine-associated adverse reactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccinia
KW - Smallpox vaccine
N1 - Accession Number: 10428687; Manischewitz, Jody 1; King, Lisa R. 1; Bleckwenn, Nicole A. 2; Shiloach, Joseph 2; Taffs, Rolf 3; Merchlinsky, Michael 1; Eller, Nancy 4; Mikolajczyk, Malgorzata G. 4; Clanton, David J. 5; Monath, Thomas 6; Weltzi, Richard A. 6; Scott, Dorothy E. 4; Golding, Hana 1; Affiliations: 1: Divisions of Viral Products; 2: Biotechnology Unit, Laboratory of Cellular and Development Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda; 3: Divisions of Emerging Transfusion Transmitted Diseases; 4: Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration; 5: Dynport Vaccine Company; 6: Acambis, Cambridge, Massachusetts; Issue Info: 8/1/2003, Vol. 188 Issue 3, p440; Subject Term: Vaccinia; Subject Term: Smallpox vaccine; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106729236
T1 - Development of a novel vaccinia-neutralization assay based on reporter-gene expression.
AU - Manischewitz J
AU - King LR
AU - Bleckwenn NA
AU - Shiloach J
AU - Taffs R
AU - Merchlinsky M
AU - Eller N
AU - Mikolajczyk MG
AU - Clanton DJ
AU - Monath T
AU - Weltzin RA
AU - Scott DE
AU - Golding H
Y1 - 2003/08//8/1/2003
N1 - Accession Number: 106729236. Language: English. Entry Date: 20040430. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Smallpox Vaccine -- Immunology
KW - Viruses
KW - Serologic Tests
KW - Genes
KW - Antibodies, Viral -- Analysis
KW - Antibodies, Viral -- Blood
KW - Immunoglobulins -- Analysis
KW - In Vitro Studies
KW - Human
SP - 440
EP - 448
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 188
IS - 3
PB - Oxford University Press / USA
AB - In anticipation of large-scale smallpox vaccination, clinical trials of new vaccine candidates with improved safety profiles, and new vaccinia immune globulin (VIG) products, there is an immediate need to develop new assays to measure vaccinia-specific immune responses. The classical assay to measure vaccinia neutralization, the plaque-reduction neutralization test (PRNT), is slow, labor intensive, and difficult to validate and transfer. Here we describe the development of a novel vaccinia-neutralization assay based on the expression of a reporter gene, beta-galactosidase (beta-Gal). Using a previously constructed vaccinia-beta-Gal recombinant virus, vSC56, we developed a neutralization assay that is rapid, sensitive, and reproducible. The readout is automated. We show that the neutralizing titers, ID(50), for several VIG products measured by our assay were similar to those obtained by PRNTs. A new Food and Drug Administration VIG standard was established for distribution to other laboratories. The new assay will serve as an important tool both for preclinical and clinical trials of new smallpox vaccines and for evaluation of therapeutic agents to treat vaccine-associated adverse reactions. Copyright © 2003 Infectious Diseases Society of America
SN - 0022-1899
AD - Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
U2 - PMID: 12870127.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Qian, Yong
AU - Castranova, Vince
AU - Shi, Xianglin
T1 - New perspectives in arsenic-induced cell signal transduction
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
Y1 - 2003/08//
VL - 96
IS - 2/3
M3 - Article
SP - 271
SN - 01620134
AB - Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-κB activation, cell cycle arrest, and apoptosis. [Copyright &y& Elsevier]
AB - Copyright of Journal of Inorganic Biochemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENICITY
KW - CARCINOGENESIS
KW - ARSENIC
KW - CELLULAR signal transduction
KW - ACTIVE oxygen
KW - Apoptosis
KW - Arsenic
KW - Cell cycle
KW - MAPK
KW - Metal
KW - NF-κB
KW - Reactive oxygen species
KW - Tyrosine phosphorylation
N1 - Accession Number: 10356894; Qian, Yong; Email Address: yqian@cdc.gov Castranova, Vince 1 Shi, Xianglin 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA; Source Info: Aug2003, Vol. 96 Issue 2/3, p271; Subject Term: CARCINOGENICITY; Subject Term: CARCINOGENESIS; Subject Term: ARSENIC; Subject Term: CELLULAR signal transduction; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Arsenic; Author-Supplied Keyword: Cell cycle; Author-Supplied Keyword: MAPK; Author-Supplied Keyword: Metal; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Tyrosine phosphorylation; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0162-0134(03)00235-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10356894&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mock, Donald M.
AU - Mock, Nell I.
AU - Stewart, Christopher W.
AU - LaBorde, James B.
AU - Hansen, Deborah K.
T1 - Marginal biotin deficiency is teratogenic in ICR mice.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003/08//
VL - 133
IS - 8
M3 - journal article
SP - 2519
EP - 2525
SN - 00223166
AB - The incidence of marginal biotin deficiency in normal human gestation is approximately one in three. In ICR mice, maternal biotin deficiency results in cleft palate, micrognathia, microglossia and limb hypoplasia. However, the relationships among the severity of maternal biotin deficiency, fetal biotin status and malformations have not been reported. This study utilized validated indices of biotin status to investigate the relationships among maternal biotin status, fetal biotin status and the rate of fetal malformations in ICR mice. Biotin status was controlled by feeding diets with varying egg white concentration. In dams and fetuses, biotin status was assessed by hepatic biotin content and hepatic activity of the biotin-dependent enzyme propionyl-CoA carboxylase; in dams, status was also assessed by urinary excretion of biotin and 3-hydroxyisovaleric acid. Malformations were assessed morphologically. Biotin was measured by HPLC/avidin-binding assay. Propionyl-CoA carboxylase (PCC) activity was determined by H(14)CO(3) incorporation. 3-Hydroxyisovaleric acid concentration was determined by GC/MS. Although no overt signs of deficiency appeared, metabolic disturbances caused by biotin deficiency were detectable in dams and fetuses. These disturbances increased with increasing egg white. Fetal biotin status correlated significantly with maternal biotin status (fetal vs. dam hepatic biotin, r = 0.671; fetal vs. dam PCC activity, r = 0.70). The incidences of malformations were strikingly dependent on egg white concentration. We conclude that in ICR mice, marginal maternal biotin deficiency causes fetal biotin deficiency. We speculate that the fetal malformations are primarily the consequence of fetal biotin deficiency. Because murine malformations appeared at degrees of biotin deficiency that are similar to those in human gestation, we speculate that some human fetal malformations may be caused by biotin deficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTIN
KW - FETUS -- Abnormalities
N1 - Accession Number: 10714557; Mock, Donald M. 1,2; Email Address: MockDonaldM@uams.edu Mock, Nell I. 1 Stewart, Christopher W. 2 LaBorde, James B. 3 Hansen, Deborah K. 3; Affiliation: 1: Departments of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, AR 2: Department of Pediatrics, University of Arkansas for Medical Sciences, AR 3: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, AR; Source Info: Aug2003, Vol. 133 Issue 8, p2519; Subject Term: BIOTIN; Subject Term: FETUS -- Abnormalities; Number of Pages: 7p; Illustrations: 1 Diagram, 4 Charts, 6 Graphs; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Jennifer L.
AU - MacDonald, Leslie A.
T1 - Hand Lacerations and Job Design Characteristics in Line-Paced Assembly.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2003/08//
VL - 45
IS - 8
M3 - Article
SP - 848
EP - 856
SN - 10762752
AB - This study investigated risk factors for laceration injuries among workers employed in line-paced manufacturing assembly operations. Most lacerations (76% of 576) occurred on the hands and fingers (grouped as "hand" lacerations). On average, 37% of surveyed workers reported at least one laceration to the hand in the preceding year, resulting in an overall hand laceration rate of 83 per 100 workers per year. An inverse relationship was found between level of job routinization and hand lacerations, with progressively higher rates of hand lacerations occurring among workers assigned to less routine (more variable) work patterns. Fabricated metal parts handling and job variability may be related to increased risk of hand lacerations in line-paced work environments where personal protective equipment is the primary strategy to control exposure to sharp objects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - WOUNDS & injuries
KW - INDUSTRIAL hygiene
N1 - Accession Number: 10893279; Bell, Jennifer L. 1; Email Address: JBELL@CDC.GOV MacDonald, Leslie A. 2; Affiliation: 1: Division of Safety Research, Analysis and Field Evaluations Branch, National Institute for Occupational Safety and Health (NIOSH), West Virginia 2: Division of Surveillance, Hazard Evaluation, and Field Studies, Industrywide Studies Branch, National Institute for Occupational Safety and Health (NIOSH), Ohio; Source Info: Aug2003, Vol. 45 Issue 8, p848; Subject Term: WORK-related injuries; Subject Term: WOUNDS & injuries; Subject Term: INDUSTRIAL hygiene; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cawley, James C.
AU - Homce, Gerald T.
T1 - Occupational electrical injuries in the United States, 1992–1998, and recommendations for safety research
JO - Journal of Safety Research
JF - Journal of Safety Research
Y1 - 2003/08//
VL - 34
IS - 3
M3 - Article
SP - 241
SN - 00224375
AB - Problem: CFOI and SOII data show that 2,287 U.S. workers died and 32,807 workers sustained days away from work due to electrical shock or electrical burn injuries between 1992 and 1998. Method: The narrative, work activity, job title, source of injury, location, and industry for each fatal electrical accident were examined. A primary causal factor was identified for each fatality. Results: Electrical fatalities were categorized into five major groups. Overall, 44% of electrical fatalities occurred in the construction industry. Contact with overhead power lines caused 41% of all electrical fatalities. Discussion: Electrical shock caused 99% of fatal and 62% of nonfatal electrical accidents. Comprising about 7% of the U.S. workforce, construction workers sustain 44% of electrical fatalities. Power line contact by mobile equipment occurs in many industries and should be the subject of focused research. Other problem areas are identified and opportunities for research are proposed. Impact on Industry: Improvements in electrical safety in one industry often have application in other industries. [Copyright &y& Elsevier]
AB - Copyright of Journal of Safety Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Electrical injuries
KW - Electric shock
KW - United States
KW - Electrical
KW - Electrical burn
KW - Electrocution
KW - Fatality
KW - Injury
KW - Shock
N1 - Accession Number: 10742069; Cawley, James C.; Email Address: Jcawley@cdc.gov; Homce, Gerald T. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh, PA 15236, USA; Issue Info: Aug2003, Vol. 34 Issue 3, p241; Thesaurus Term: Industrial safety; Subject Term: Electrical injuries; Subject Term: Electric shock; Subject: United States; Author-Supplied Keyword: Electrical; Author-Supplied Keyword: Electrical burn; Author-Supplied Keyword: Electrocution; Author-Supplied Keyword: Fatality; Author-Supplied Keyword: Injury; Author-Supplied Keyword: Shock; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0022-4375(03)00028-8
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wang, Jingxin
AU - Bell, Jennifer L.
AU - Grushecky, Shawn T.
T1 - Logging injuries for a 10-year period in Jilin Province of the People's Republic of China
JO - Journal of Safety Research
JF - Journal of Safety Research
Y1 - 2003/08//
VL - 34
IS - 3
M3 - Article
SP - 273
SN - 00224375
AB - Problem: Logging continues to be a major source of injuries in northeast China. This paper describes logging-related injuries in the Jilin Province of the People''s Republic of China. Methods: Logging fatalities and nonfatal injuries were summarized from 1981 to 1990 in Jilin. Injury data from 1991 for the entire forestry sector in China were also analyzed. Results: Fatalities were mainly from of head injuries and were caused by being struck by an object. Nonfatal injuries were most often to the lower extremities and the head and were normally caused by being struck by an object or a fall or slip. The majority of both fatal and nonfatal logging injuries occurred to workers with less than 1 year of employment and those under 35 years old. Most injuries occurred November through March in Jilin. Impact on industry: Patterns of logging injury in Jilin of China were similar, but not identical, to those described in other studies of logging injuries worldwide. Methods found to be effective in reducing logging-related injuries in other parts of the world might be used in China to reduce the injuries associated with logging. [Copyright &y& Elsevier]
AB - Copyright of Journal of Safety Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Forests & forestry
KW - Work-related injuries
KW - Jilin Sheng (China)
KW - China
KW - Accident
KW - Forest operations
KW - Injuries and fatalities
KW - Logging
KW - Safety
N1 - Accession Number: 10742072; Wang, Jingxin 1; Email Address: jxwang@wvu.edu; Bell, Jennifer L. 2; Email Address: jbell@cdc.gov; Grushecky, Shawn T. 1; Email Address: sgrushec@wvu.edu; Affiliations: 1: Division of Forestry, West Virginia University, P.O. Box 6125, Morgantown, WV 26506-6125, USA; 2: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA; Issue Info: Aug2003, Vol. 34 Issue 3, p273; Thesaurus Term: Forests & forestry; Subject Term: Work-related injuries; Subject: Jilin Sheng (China); Subject: China; Author-Supplied Keyword: Accident; Author-Supplied Keyword: Forest operations; Author-Supplied Keyword: Injuries and fatalities; Author-Supplied Keyword: Logging; Author-Supplied Keyword: Safety; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0022-4375(03)00024-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=10742072&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Argaw, Takele
AU - Ritzhaupt, Armin
AU - Wilson, Carolyn A.
T1 - Corrigendum to “Development of a real time quantitative PCR assay for detection of porcine endogenous retrovirus”: [J. Virol. Methods 106 (2002) 97–106]
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2003/08//
VL - 111
IS - 2
M3 - Correction notice
SP - 165
SN - 01660934
N1 - Accession Number: 10323425; Argaw, Takele 1 Ritzhaupt, Armin 1 Wilson, Carolyn A.; Email Address: wilsonc@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Source Info: Aug2003, Vol. 111 Issue 2, p165; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/S0166-0934(03)00168-X
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Price, D.D.
AU - Riley III, J.L.
AU - Vase, L.
T1 - Reliable differences in placebo effects between clinical analgesic trials and studies of placebo analgesia mechanisms
JO - Pain (03043959)
JF - Pain (03043959)
Y1 - 2003/08//
VL - 104
IS - 3
M3 - Letter
SP - 715
SN - 03043959
N1 - Accession Number: 10570875; Price, D.D. 1; Email Address: dprice@dental.ufl.edu Riley III, J.L. 2 Vase, L. 3; Affiliation: 1: Departments of Oral and Maxillofacial Surgery and Neuroscience, University of Florida, PO Box 100416, Gainesville, FL 32610-0416, USA 2: Public Health Service and Research, College of Dentistry University of Florida, PO Box 100416,Gainesville, FL 32610-0416, USA 3: Department of Clinical and Health Pschology, University of Florida, PO Box 100416, Gainesville, FL 32610-0416, USA; Source Info: Aug2003, Vol. 104 Issue 3, p715; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/S0304-3959(03)00165-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10570875&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thompson, K. L.
AU - Sistare, F. D.
T1 - Selection of Drugs to Test the Specificity of the Tg.AC Assay by Screening for Induction of the gadd153 Promoter in Vitro.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/08//
VL - 74
IS - 2
M3 - Article
SP - 260
EP - 270
PB - Oxford University Press / USA
SN - 10966080
AB - Short-term assays for carcinogenicity testing of chemicals that use transgenic mice designed to have altered expression of genes mechanistically relevant to carcinogenesis are attractive alternatives to two-year dosing studies in rodents. The models that have been the received the greatest level of performance evaluation include p53(+/-), rasH2, Xpa/p53(+/-), and Tg.AC mice. For use of these models in a regulatory setting to evaluate the carcinogenic potential of pharmaceuticals, it is important to establish an assurance of assay specificity and positive predictivity based on studies using drugs with a wide spectrum of pharmacologic activity. For this purpose, 99 noncarcinogenic drugs were prioritized based on their activity in an in vitro induction assay correlative with a positive response in the Tg.AC assay (induction of the gadd153 promoter in HepG2 cells). Activities in two assays less predictive of Tg.AC activity (induction of c-fos and ζ-globin gene promoters) were also measured. Nine percent of the screened drugs induced the gadd153 promoter by at least fourfold. Several criteria were used to select candidates for subsequent in vivo testing in the Tg.AC assay: (1) sufficient drug solubility in appropriate skin paint vehicles to elicit systemic toxicity, (2) the level of induction of the gadd153 promoter by the drug, (3) the in vitro potency of the drug, and (4) the cost of the drug required for a 6-month study. Based on these criteria, amiloride, dipyridamole, and pyrimethamine were selected from 99 rodent noncarcinogens in a drug database for testing the specificity of the Tg.AC assay. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transgenic animals
KW - Chronic toxicity testing
KW - Heredity
KW - Transgenic mice
KW - Mice as laboratory animals
KW - Genes
KW - ζ-globin
KW - c-fos
KW - gadd153
KW - HepG2
KW - K562
KW - Tg.AC
N1 - Accession Number: 20605898; Thompson, K. L. 1; Email Address: Thompsonk@cder.fda.gov; Sistare, F. D. 1; Affiliations: 1: Division of Applied Pharmacology Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708; Issue Info: Aug2003, Vol. 74 Issue 2, p260; Thesaurus Term: Transgenic animals; Thesaurus Term: Chronic toxicity testing; Thesaurus Term: Heredity; Subject Term: Transgenic mice; Subject Term: Mice as laboratory animals; Subject Term: Genes; Author-Supplied Keyword: ζ-globin; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: gadd153; Author-Supplied Keyword: HepG2; Author-Supplied Keyword: K562; Author-Supplied Keyword: Tg.AC; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1093/toxsci/kfg113
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20605898&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thompson, K. L.
AU - Rosenzweig, B. A.
AU - Weaver, J. L.
AU - Zhang, J.
AU - Lin, K. K.
AU - Sistare, F. D.
T1 - Evaluation of the Tg.AC Assay: Specificity Testing with Three Noncarcinogenic Pharmaceuticals that Induce Selected Stress Gene Promoters in Vitro and the Inhibitory Effects of Solvent Components.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/08//
VL - 74
IS - 2
M3 - Article
SP - 271
EP - 278
PB - Oxford University Press / USA
SN - 10966080
AB - Understanding the strengths and limitations of alternative models, such as the Tg.AC assay, for evaluation of the potential carcinogenicity of pharmaceuticals requires assessment of assay specificity through studies that specifically target biologically active compounds that are known to not be carcinogens in rodents. To identify drugs that might provoke a false positive response in the Tg.AC assay, we screened pharmaceuticals for in vitro induction of the gadd153 promoter and the ζ-globin promoter. We have previously found a high correlation between induction of the gadd153 promoter in HepG2 cells and activity in the Tg.AC assay. The three drugs selected through screening 99 noncarcinogenic pharmaceuticals were amiloride, dipyridamole, and pyrimethamine. A 26-week skin paint study was conducted in hemizygous Tg.AC mice with the three drugs at two doses selected by a 4-week dose range finding study. Evidence of systemic toxicity was observed in animals dosed chronically with pyrimethamine or amiloride, but no skin papillomas were observed in mice treated with amiloride, dipyridamole, or pyrimethamine for 26 weeks. All male mice and 80% of female mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) in acetone developed a maximal tumor burden. However, mice treated with TPA in a vehicle containing 2.4% DMSO had greatly reduced incidences of papillomas. In summary, the correct negative response was shown in the Tg.AC assay for three noncarcinogenic pharmaceuticals, which adds further favorable evidence of appropriate specificity of this model system. However, vehicle composition must be carefully selected because the outcome of this assay can be confounded by certain commonly used solvents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Transgenic animals
KW - Bioactive compounds
KW - Transgenic mice
KW - Mice as laboratory animals
KW - Papillomavirus diseases
KW - DMSO
KW - gadd153
KW - solvent
KW - Tg.AC
KW - TPA
N1 - Accession Number: 20605899; Thompson, K. L. 1; Email Address: thompsonk@cder.fda.gov; Rosenzweig, B. A. 1; Weaver, J. L. 1; Zhang, J. 1; Lin, K. K. 2; Sistare, F. D. 1; Affiliations: 1: Division of Applied Pharmacology Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Food and Drug Administration, Laurel, Maryland 20708; 2: Division of Biometrics II, Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland 20708; Issue Info: Aug2003, Vol. 74 Issue 2, p271; Thesaurus Term: Carcinogenesis; Thesaurus Term: Transgenic animals; Thesaurus Term: Bioactive compounds; Subject Term: Transgenic mice; Subject Term: Mice as laboratory animals; Subject Term: Papillomavirus diseases; Author-Supplied Keyword: DMSO; Author-Supplied Keyword: gadd153; Author-Supplied Keyword: solvent; Author-Supplied Keyword: Tg.AC; Author-Supplied Keyword: TPA; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1093/toxsci/kfg141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20605899&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - David, Laurence S.
AU - Plakas, Steven M.
AU - El Said, Kathleen R.
AU - Jester, Edward L.E.
AU - Dickey, Robert W.
AU - Nicholson, Russell A.
T1 - A rapid assay for the brevetoxin group of sodium channel activators based on fluorescence monitoring of synaptoneurosomal membrane potential
JO - Toxicon
JF - Toxicon
Y1 - 2003/08//
VL - 42
IS - 2
M3 - Article
SP - 191
SN - 00410101
AB - A functional pharmacologically-based assay for the brevetoxin group of sodium channel activators was developed using synaptoneurosomes isolated from the brains of CD1 mice. The assay can detect the depolarizing effect of brevetoxin congeners PbTx-2 and PbTx-3 as enhancements of the veratridine-dependent increase in fluorescence of the voltage-sensitive fluorescent probe rhodamine 6G. The assay is relatively rapid and can detect brevetoxin activity in the nanomolar range. The synaptoneurosomal assay has been used to analyse mussel tissue extracts spiked with PbTx-2, and composite toxicity, expressed as PbTx-3 equivalents in extracts of oysters naturally exposed to brevetoxins. In this latter context, the synaptoneurosomal technique was shown to compare favorably with the cytotoxicity assay, the receptor binding assay and HPLC/MS. Our results support the concept that this membrane potential assay detects brevetoxins based on their interaction with sodium channels. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXINS
KW - SODIUM channels
KW - BRAIN
KW - Brevetoxins
KW - Membrane potential
KW - Mouse brain synaptoneurosomes
KW - NSP toxin assay
KW - Rhodamine 6G
KW - Voltage-sensitive sodium channels
N1 - Accession Number: 10425610; David, Laurence S. 1 Plakas, Steven M. 2 El Said, Kathleen R. 2 Jester, Edward L.E. 2 Dickey, Robert W. 2 Nicholson, Russell A. 1; Email Address: nicholso@sfu.ca; Affiliation: 1: Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6 2: Gulf Coast Seafood Laboratory, US Food and Drug Administration, Dauphin Island, AL 36528, USA; Source Info: Aug2003, Vol. 42 Issue 2, p191; Subject Term: TOXINS; Subject Term: SODIUM channels; Subject Term: BRAIN; Author-Supplied Keyword: Brevetoxins; Author-Supplied Keyword: Membrane potential; Author-Supplied Keyword: Mouse brain synaptoneurosomes; Author-Supplied Keyword: NSP toxin assay; Author-Supplied Keyword: Rhodamine 6G; Author-Supplied Keyword: Voltage-sensitive sodium channels; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0041-0101(03)00133-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10425610&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2003-07093-001
AN - 2003-07093-001
AU - Marconi, Katherine
AU - Moore, Richard
T1 - Commentary: The importance of demonstrations in developing adolescent HIV care models.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2003/08//
VL - 33
IS - Suppl2
SP - 1
EP - 3
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Marconi, Katherine, Office of Science & Epidemiology, HIV/AIDS Bureau, HRSA, 5600 Fishers Lane, Rm. 7-90, Rockville, MD, US, 20857
N1 - Accession Number: 2003-07093-001. Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Marconi, Katherine; United States Dept of Health & Human Services, Health Resources & Service Administration, HIV/AIDS Bureau, Office of Science & Epidemiology, Rockville, MD, US. Release Date: 20030811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Government Policy Making; Health Care Services; HIV. Minor Descriptor: Adolescent Development; Laws. Classification: Immunological Disorders (3291); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 3. Issue Publication Date: Aug, 2003.
AB - Provides a brief overview of this supplement to the Journal of Adolescent Medicine. The supplement reports on five grants funded by the U. S. Departments of Health and Human Services (HHS), Health Resources and Services Administration (HRSA), and Housing and Urban Development (HUD). The grants are part of the Special Projects of National Significance (SPNS) program, which is the research and development arm of the Ryan White Comprehensive AIDS Resources Emergency Act (P.L. 101-381) as amended by the Ryan White CARE Act Amendments of 1996 and 2000 (P.L. 104-146 and P.L. 106-345). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent medicine
KW - grants
KW - government policies
KW - laws
KW - HIV/AIDS resources & care
KW - 2003
KW - AIDS
KW - Government Policy Making
KW - Health Care Services
KW - HIV
KW - Adolescent Development
KW - Laws
KW - 2003
DO - 10.1016/S1054-139X(03)00162-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-07093-001&site=ehost-live&scope=site
UR - kmarconi@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-22258-007
AN - 2004-22258-007
AU - Leonardson, Gary R.
AU - Daniels, Mark C.
AU - Nees, Frederick K.
AU - Kemper, Erica
AU - Mihura, Joni L.
AU - Koplin, Brett A.
AU - Foreyt, John P.
T1 - Validity and reliability of the general well-being schedule with Northern Plains American Indians diagnosed with type 2 diabetes mellitus.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 2003/08//
VL - 93
IS - 1
SP - 49
EP - 58
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
AD - Leonardson, Gary R., Mountain Plains Research, 55 Rodeo Trl., Dillon, MT, US, 59725
N1 - Accession Number: 2004-22258-007. PMID: 14563026 Partial author list: First Author & Affiliation: Leonardson, Gary R.; Mountain Plains Research, Dillon, MT, US. Other Publishers: Sage Publications. Release Date: 20050124. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Diabetes Mellitus; Distress; Test Reliability; Test Validity. Minor Descriptor: Psychometrics; Well Being; Type 2 Diabetes. Classification: Health Psychology Testing (2226); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: family-Adaptation, Partnership, Growth, Affection, & Resolve; Beck Depression Inventory–II DOI: 10.1037/t00742-000; Symptom Checklist-90–Revised DOI: 10.1037/t01210-000; General Well-Being Schedule DOI: 10.1037/t04083-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 2003.
AB - The General Well-being Schedule is a brief indicator of subjective feelings of psychological well-being and distress. It is easy to administer, reliable, and valid, although its validity with American Indians has not been established. This study then assessed reliability, validity, and factor structure for a sample of 88 diabetic American Indians, who sought care for diabetes at an Indian Health Service hospital. Cronbach alpha was .89. A factor analysis indicated four dimensions. Adequate concurrent and divergent validity were noted in association with scores on the Beck Depression Inventory-Second Edition, the depression scale on the Symptom Checklist- 90-Revised, and Family-Adaptation, Partnership, Growth, Affection, & Resolve. These results suggest that the General Well-being Schedule is a reliable and valid measure of general well-being for this population of American Indians. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - General Well-Being Schedule
KW - diabetic American Indians
KW - diabetes mellitus
KW - subjective feelings
KW - psychometrics
KW - psychological well-being
KW - distress
KW - 2003
KW - American Indians
KW - Diabetes Mellitus
KW - Distress
KW - Test Reliability
KW - Test Validity
KW - Psychometrics
KW - Well Being
KW - Type 2 Diabetes
KW - 2003
DO - 10.2466/PR0.93.5.49-58
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-22258-007&site=ehost-live&scope=site
UR - mpr@bmt.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-07378-008
AN - 2003-07378-008
AU - Slotkin, Theodore A.
AU - Freibaum, Brian D.
AU - Tate, Charlotte A.
AU - Thillai, Indira
AU - Ferguson, Sherry A.
AU - Cada, Amy M.
AU - Seidler, Frederic J.
T1 - Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: Nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2003/08//
VL - 981
IS - 1-2
SP - 118
EP - 125
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Slotkin, Theodore A., Department of Pharmacology & Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC, US, 27710
N1 - Accession Number: 2003-07378-008. PMID: 12885432 Partial author list: First Author & Affiliation: Slotkin, Theodore A.; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, US. Release Date: 20031215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cholinergic Receptors; Decarboxylases; Drug Therapy; Neural Development; Neurophysiology. Minor Descriptor: Cerebellum; Chemicals; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2003.
AB - We administered α-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), to neonatal rats on postnatal days 5-12, during the mitotic peak of the cerebellum, a treatment regimen that achieves a chemical knockout of ODC activity and polyamine depletion limited to the treatment period. Although growth inhibition and gross dysmorphology were limited to the cerebellum, both α and α4β2 nAChRs were upregulated in adulthood in the frontal cortex, hippocampus and thalamus, with the largest effect in the latter region, primarily in females. Receptor upregulation was accompanied by abnormalities in macromolecular indices of cell packing density and cell membrane surface area, but the generalized cellular alterations did not share the regional or sex selectivity shown by the effects on nAChRs. Elevated DNA concentration was most notable in the hippocampus and was associated with augmented levels of glial fibrillary acidic protein, thus implying gliosis as the cause of the increased number of cells. DFMO's effects on both nAChR expression and cellular biomarkers resembled those of developmental exposure to nicotine. Some of the effects may represent a specific alteration in nAChR signaling evoked by polyamine depletion during a developmental window. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ornithine decarboxylase
KW - cerebellum
KW - knockout
KW - alpha difluoromethylornithine
KW - polyamine depletion
KW - nicotinic cholinergic receptor upregulation
KW - neural development
KW - macromolecular changes
KW - rats
KW - 2003
KW - Cholinergic Receptors
KW - Decarboxylases
KW - Drug Therapy
KW - Neural Development
KW - Neurophysiology
KW - Cerebellum
KW - Chemicals
KW - Rats
KW - 2003
DO - 10.1016/S0006-8993(03)02993-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-07378-008&site=ehost-live&scope=site
UR - t.slotkin@duke.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-05980-003
AN - 2003-05980-003
AU - Scott, Lionel D. Jr.
T1 - Cultural orientation and coping with perceived discrimination among African American youth.
JF - Journal of Black Psychology
JO - Journal of Black Psychology
JA - J Black Psychol
Y1 - 2003/08//
VL - 29
IS - 3
SP - 235
EP - 256
CY - US
PB - Sage Publications
SN - 0095-7984
SN - 1552-4558
N1 - Accession Number: 2003-05980-003. Partial author list: First Author & Affiliation: Scott, Lionel D. Jr.; Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO, US. Release Date: 20030811. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Blacks; Coping Behavior; Culture (Anthropological); Race and Ethnic Discrimination. Minor Descriptor: Ethnic Identity; Individuality; Racial and Ethnic Differences; Spirituality. Classification: Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 22. Issue Publication Date: Aug, 2003.
AB - This study sought to explore whether the resonance of certain orientations and dimensions asserted to be distinctive of Black culture (effect, communalism, and spirituality) and mainstream American culture (competition, effort optimism, and individualism) were related to the strategies used by African American youth to cope with perceived discrimination. Participants were 120 African American youth (age 14-18 yrs) from two geographical regions in the US (northern Alabama, n = 71; central Ohio, n = 49). The findings suggested that orientations and corresponding dimensions of Black culture and mainstream American culture might evidence varying degrees of resonance among African American youth from disparate social-environmental contexts. The findings also indicated that spirituality and effort optimism were related to greater use of self-reliance/problem solving coping strategies, whereas communalism was related to lower use of externalizing coping strategies. The implications of cultural orientation for the adjustment and psychological functioning of African American youth in the face of multiple racial contingencies are discussed (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - African American youth
KW - cultural orientation
KW - mainstream American culture
KW - Black culture
KW - discrimination
KW - resonance
KW - coping strategies
KW - 2003
KW - Adolescent Attitudes
KW - Blacks
KW - Coping Behavior
KW - Culture (Anthropological)
KW - Race and Ethnic Discrimination
KW - Ethnic Identity
KW - Individuality
KW - Racial and Ethnic Differences
KW - Spirituality
KW - 2003
DO - 10.1177/0095798403254213
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-05980-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99651-010
AN - 2003-99651-010
AU - Bednarek, Heather L.
AU - Schone, Barbara Steinberg
T1 - Variation in preventive service use among the insured and uninsured: Does length of time without coverage matter?
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2003/08//
VL - 14
IS - 3
SP - 403
EP - 419
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
N1 - Accession Number: 2003-99651-010. PMID: 12955919 Partial author list: First Author & Affiliation: Bednarek, Heather L.; St. Louis University, St. Louis, MO, US. Release Date: 20040628. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Insurance; Preventive Medicine; Uninsured (Health Insurance). Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Aug, 2003.
AB - Lacking health insurance has consequences for the ways in which individuals seek care. In this research, the authors use data from the first panel (1996) of the Medical Expenditure Panel Survey to assess the relationship between preventive services and the length of time with insurance during a 12-month period. Regression analyses show that individuals with continuous coverage during the entire period have dramatically higher rates of preventive service use than individuals who lack coverage for all 12 months. For most services, the authors also find modest differences in preventive service use between the continually insured and those individuals with coverage for 1 to 6 months. Rates of preventive service use for individuals with 7 to 11 months of coverage are statistically indistinguishable from the continually insured. The authors' findings highlight the importance of considering the length of time without coverage when evaluating preventive service use of the uninsured population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventive service use
KW - health insurance
KW - uninsured population
KW - 2003
KW - Health Care Services
KW - Health Insurance
KW - Preventive Medicine
KW - Uninsured (Health Insurance)
KW - 2003
DO - 10.1353/hpu.2010.0529
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99651-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99699-001
AN - 2003-99699-001
AU - Stryer, Daniel
T1 - Steps Across the Gap: Tools, Trials and Data.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2003/08//
VL - 41
IS - 8
SP - 871
EP - 873
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Stryer, Daniel, Center tor Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD, US, 20850
N1 - Accession Number: 2003-99699-001. PMID: 12886167 Partial author list: First Author & Affiliation: Stryer, Daniel; Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20040628. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Health Care Services; Measurement; Quality of Care; Quality of Services. Minor Descriptor: Data Collection; Health Care Costs. Classification: Health & Mental Health Services (3370); Research Methods & Experimental Design (2260). Population: Human (10). Location: US. References Available: Y. Page Count: 3. Issue Publication Date: Aug, 2003.
AB - In this issue, Drs. Sim and Cummings introduce a new method for quantifying opportunities for improvement, the Number Not Prevented (NNP). NNP represents the number of events that could be expected to occur in a year that would not have occurred had care been provided alternatively. The NNP is a nice addition to methods for quantifying opportunities because it is readily understandable and easy to calculate. The authors caution that the number has some limitations and that it can be misinterpreted if viewed in isolation from other evidence. The NNP is limited because comparisons across quality improvement opportunities can be done for only one outcome at a time. An alternative approach that has been used in prioritizing clinical preventive services is the Clinically Preventable Burden (CPB). It is a function of the effectiveness of a service in reducing certain morbidities and mortality as expressed in a common measure of health outcome such as quality-adjusted life years (QALYs), and a function of the percent reduction in burden addressed by a service. Both the NNP and CPB lack a key element needed to inform prioritization: the need to consider the costs of the intervention as well as the costs necessary to improve the rates of adherence to evidence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quantifying opportunities
KW - quality improvement
KW - clinical preventive services
KW - service effectiveness
KW - Number Not Prevented
KW - Clinically Preventable Burden
KW - 2003
KW - Health Care Services
KW - Measurement
KW - Quality of Care
KW - Quality of Services
KW - Data Collection
KW - Health Care Costs
KW - 2003
DO - 10.1097/00005650-200308000-00001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99699-001&site=ehost-live&scope=site
UR - dstryer@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99749-002
AN - 2003-99749-002
AU - Pavlin, Julie A.
AU - Mostashari, Farzad
AU - Kortepeter, Mark G.
AU - Hynes, Noreen A.
AU - Chotani, Rashid A.
AU - Mikol, Yves B.
AU - Ryan, Margaret A. K.
AU - Neville, James S.
AU - Gantz, Donald T.
AU - Writer, James V.
AU - Florance, Jared E.
AU - Culpepper, Randall C.
AU - Henretig, Fred M.
AU - Kelley, Patrick W.
T1 - Innovative surveillance methods for rapid detection of disease outbreaks and bioterrorism: Results of an interagency workshop on health indicator surveillance.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/08//
VL - 93
IS - 8
SP - 1230
EP - 1235
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Pavlin, Julie A., Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD, US, 20910
N1 - Accession Number: 2003-99749-002. PMID: 12893601 Partial author list: First Author & Affiliation: Pavlin, Julie A.; Department of Defense Global Emerging Infections System, Silver Spring, MD, US. Release Date: 20041115. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bioterrorism; Epidemics; Public Health Services; Terrorism. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. References Available: Y. Page Count: 6. Issue Publication Date: Aug, 2003.
AB - The Department of Defense Global Emerging Infections System sponsored a meeting and workshop in May 2000 in which participants discussed prototype systems and developed recommendations for new surveillance systems for rapid detection of an infectious disease outbreak or bioterrorism attack. The article provides a summary of the group's findings, including expectations and recommendations for new surveillance systems, reviews the need to improve public health capabilities in the United States, in light of recent tragic events and discusses the expectations for a health indicator surveillance system and the existing prototype systems. It further discusses the key issues in developing such system and the usefulness of such a system. The consensus of the group reported that a nationally led effort in developing health indicator surveillance methods is needed to promote effective, innovative systems. It is concluded that that the creation of a national working group on innovative surveillance strategies may help to harmonize current efforts and encourage further innovation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bioterrorism
KW - surveillance system
KW - infectious disease
KW - disease outbreak
KW - 2003
KW - Bioterrorism
KW - Epidemics
KW - Public Health Services
KW - Terrorism
KW - 2003
DO - 10.2105/AJPH.93.8.1230
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99749-002&site=ehost-live&scope=site
UR - julie.pavlin@amedd.army.mil
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-99789-006
AN - 2003-99789-006
AU - Riegel, AC
AU - Ali, SF
AU - French, ED
T1 - Toluene-Induced Locomotor Activity is Blocked by 6-Hydroxydopamine Lesions of the Nucleus Accumbens and the mGluR2/3 Agonist LY379268.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2003/08//
VL - 28
IS - 8
SP - 1440
EP - 1447
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
AD - French, ED, Department of Pharmacology, University of Arizona, College of Medicine,, Tucson, AZ, US, 85724-5050
N1 - Accession Number: 2003-99789-006. PMID: 12784113 Partial author list: First Author & Affiliation: Riegel, AC; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, US. Release Date: 20030915. Correction Date: 20100510. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Locomotion; Dopamine Agonists; Neurotransmission; Nucleus Accumbens; Toluene. Minor Descriptor: Activity Level; Drug Abuse; Hydroxydopamine (6-); Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2003.
AB - The abuse of volatile inhalants remains a prominent, yet poorly understood, form of substance abuse among youth. Nevertheless, the identification of a mechanism underlying the reinforcing properties of inhalants has been hampered by the lack of a clearly identifiable neural substrate upon which these chemicals act. One ingredient that is common to many abused inhalants is toluene, an organic solvent that is self-administered by nonhuman primates and rodents. Most drugs of abuse have been found to elicit forward locomotion in rats, an effect owing to the activation of mesoaccumbal dopamine (DA) pathways. Thus, the present study was undertaken using two different approaches to determine whether toluene-induced locomotor hyperactivity is also ultimately dependent upon DA neurotransmission in the mesolimbic nucleus accumbens (NAC). Here we report on the effects of 6-hydroxydopamme (6-OHDA) lesions of the NAC or pretreatment with the metabotropic mGlu2/3 receptor agonist LY379268 on toluene-induced locomotor activity. Both procedures, which are known to alter neurotransmission within the NAC, significantly attenuated toluene's locomotor stimulatory effects. These results provide strong support for a central mechanism of action of inhalants, which in the past has been more typically... (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nucleus accumbens
KW - toluene-induced locomotor hyperactivity
KW - reinforcing properties
KW - da neurotransmission
KW - receptor agonist
KW - 2003
KW - Animal Locomotion
KW - Dopamine Agonists
KW - Neurotransmission
KW - Nucleus Accumbens
KW - Toluene
KW - Activity Level
KW - Drug Abuse
KW - Hydroxydopamine (6-)
KW - Rats
KW - 2003
DO - 10.1038/sj.npp.1300193
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-99789-006&site=ehost-live&scope=site
UR - efrench@u.arizona.edu
DP - EBSCOhost
DB - psyh
ER -
TY - GEN
AU - Brassey, Jon R.
T1 - "Hitting the Headlines" is useful resource.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2003/08/02/
VL - 327
IS - 7409
M3 - Letter
SP - 291
SN - 09598146
AB - Presents a letter to the editor in response to a review by Schwitzer of medical web sites.
KW - LETTERS to the editor
KW - MEDICINE
KW - COMPUTER network resources
N1 - Accession Number: 10464522; Brassey, Jon R. 1; Email Address: jon@tripdatabase.com; Affiliation: 1: TRIP database, National Public Health Service Wales, Pontypool NP4 0YP; Source Info: 8/2/2003, Vol. 327 Issue 7409, p291; Subject Term: LETTERS to the editor; Subject Term: MEDICINE; Subject Term: COMPUTER network resources; Number of Pages: 1/7p; Document Type: Letter; Full Text Word Count: 168
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106723326
T1 - Commentary: the importance of demonstrations in developing adolescent HIV care models.
AU - Marconi K
AU - Moore R
Y1 - 2003/08/02/Aug2003 Supplement
N1 - Accession Number: 106723326. Language: English. Entry Date: 20040416. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Aug2003 Supplement. Journal Subset: Allied Health; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 9102136.
KW - HIV Infections -- Therapy -- In Adolescence
KW - Adolescence
KW - Grants
KW - Research Support
SP - 1
EP - 3
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
JA - J ADOLESC HEALTH
VL - 33
CY - New York, New York
PB - Elsevier Science
SN - 1054-139X
AD - Director, Office of Science and Epidemiology, HIV/AIDS Bureau, HRSA, 5600 Fishers Lane, Rm 7-90, Rockville, MD 20857; kmarconi@hrsa.gov
U2 - PMID: 12888281.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106723326&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - O'Brien, Katherine L.
AU - Moulton, Lawrence H.
AU - Reid, Raymond
AU - Weatherholtz, Robert
AU - Oski, Jane
AU - Brown, Laura
AU - Kumar, Gaurav
AU - Parkinson, Alan
AU - Hu, Diana
AU - Hackell, Jill
AU - Ih Chang
AU - Kohberger, Robert
AU - Siber, George
AU - Santosham, Mathuram
T1 - Efficacy and safety of seven-valent conjugate pneumococcal vaccine in American Indian children: group randomised trial.
JO - Lancet
JF - Lancet
Y1 - 2003/08/02/
VL - 362
IS - 9381
M3 - Article
SP - 355
PB - Lancet
SN - 00995355
AB - Background Streptococcus pneumoniae is the main cause of invasive bacterial disease in children aged younger than 2 years. Navajo and White Mountain Apache children have some of the highest rates of invasive pneumococcal disease documented in the world. We aimed to assess the safety and efficacy of a seven-valent polysaccharide protein conjugate pneumococcal vaccine (PnCRM7) against such disease. Methods In a group-randomised study, we gave this vaccine to children younger than 2 years from the Navajo and White Mountain Apache Indian reservations; meningococcal type conjugate vaccine (MnCC) served as the control vaccine. Vaccine schedules were determined by age at enrolment. We recorded episodes of invasive pneumococcal disease and serotyped isolates. Analyses were by intention to treat and per protocol. Findings 8292 children enrolled in the trial. In the per protocol analysis of the primary efficacy group (children enrolled by 7 months of age) there were eight cases of vaccine serotype disease in the controls and two in the PnCRM7 group; in the intention-to-treat analysis we noted 11 cases of vaccine serotype disease in the MnCC control group and two in the PnCRM7 group. After group randomisation had been controlled for, the per protocol primary efficacy of PnCRM7 was 76.8% and the intention-to-treat total primary efficacy was 82.6%. Interpretation PnCRM7 vaccine prevents vaccine serotype invasive pneumococcal disease even in a high risk population. Other regions with similar disease burden should consider including this vaccine in the routine childhood vaccine schedule. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STREPTOCOCCUS pneumoniae
KW - BACTERIAL diseases
KW - JUVENILE diseases
KW - NATIVE Americans
KW - VACCINATION
N1 - Accession Number: 10440221; O'Brien, Katherine L. 1; Email Address: klobrien@jhsph.edu Moulton, Lawrence H. 2 Reid, Raymond 1 Weatherholtz, Robert 1 Oski, Jane 1 Brown, Laura 1 Kumar, Gaurav 1 Parkinson, Alan 3 Hu, Diana 4 Hackell, Jill 5 Ih Chang 5 Kohberger, Robert 5 Siber, George 5 Santosham, Mathuram 1; Affiliation: 1: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2: Departments of International Health and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 3: Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK 4: Indian Health Service, Department of Health and Human Services, Tuba City, Arizona 5: Wyeth Vaccines, Pearl River, NY; Source Info: 8/2/2003, Vol. 362 Issue 9381, p355; Subject Term: STREPTOCOCCUS pneumoniae; Subject Term: BACTERIAL diseases; Subject Term: JUVENILE diseases; Subject Term: NATIVE Americans; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article; Full Text Word Count: 6675
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Toraason, Mark
AU - Butler, Mary Ann
AU - Ruder, Avima
AU - Forrester, Christy
AU - Taylor, Lauralynn
AU - Ashley, David L.
AU - Mathias, Patty
AU - Marlow, Kate L.
AU - Cheever, Kenneth L.
AU - Krieg, Edward
AU - Wey, Howard
T1 - Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2003/08/05/
VL - 539
IS - 1/2
M3 - Article
SP - 9
SN - 13835718
AB - Perchloroethylene (PERC) is used widely as an industrial dry cleaning solvent and metal degreaser. PERC is an animal carcinogen that produces increased incidence of renal adenomas, adenocarcinomas, mononuclear cell leukemia, and hepatocellular tumors. Oxidative DNA damage and lipid peroxidation were assessed in 38 women with (dry cleaners) or without (launderers) occupational exposure to PERC. PERC exposure was assessed by collecting breathing zone samples on two consecutive days of a typical work week. PERC levels were measured in blood drawn on the morning of the second day of breathing zone sample collection in dry cleaners and before a typical workday in launderers. Blood PERC levels were two orders of magnitude higher in dry cleaners compared to launderers. A significant correlation was noted between time weighted average (TWA) PERC and blood PERC in dry cleaners (r=0.7355 , P<0.002 ). 8-Hydroxydeoxyguanosine (8-OHdG), ng/mg deoxyguanosine (dG) in leukocyte nuclear DNA was used as an index of steady-state oxidative DNA damage. Urinary 8-OHdG, μg/g creatinine was used as an index of oxidative DNA damage repair. Urinary 8-epi-prostaglandin F2α (8-epi-PGF), ng/g creatinine was used as an index of lipid peroxidation. The mean±S.D. leukocyte 8-OHdG in launderers was 16.0±7.3 and was significantly greater than the 8.1±3.6 value for dry cleaners. Urinary 8-OHdG and 8-epi-PGF were not significantly different between dry cleaners and launderers. Unadjusted Pearson correlation analysis of log transformed PERC exposure indices and biomarkers of oxidative stress indicated a significant association in launderers between blood PERC and day 1 urinary 8-OHdG (r=0.4661 , P<0.044 ). No significant associations between exposure indices and biomarkers were evident in linear models adjusted for age, body mass index, race, smoking (urinary cotinine, mg/g creatinine) and blood levels of the antioxidants Vitamin E and β-carotene. The mean±S.D. leukocyte 8-OHdG value in control white women was 17.8±7.4 and was significantly greater than the 11.8±5.9 in control black women. No significant differences by race were evident for the other biomarkers. Smoking status was not significantly associated with any of the oxidative damage indices. Results indicate a reduction in oxidative DNA damage in PERC exposed dry cleaners relative to launderers, but PERC could not clearly be defined as the source of the effect. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tetrachloroethylene
KW - Carcinogenesis
KW - Dry cleaning
KW - Tumors
KW - 8-Hydroxydeoxyguanosine
KW - Oxidative DNA damage
KW - Perchloroethylene
KW - Race
KW - Tobacco smoking
N1 - Accession Number: 10636623; Toraason, Mark 1; Email Address: mtoraason@cdc.gov; Butler, Mary Ann 1; Ruder, Avima 1; Forrester, Christy 1; Taylor, Lauralynn 1; Ashley, David L. 2; Mathias, Patty 1; Marlow, Kate L. 1; Cheever, Kenneth L. 1; Krieg, Edward 1; Wey, Howard 3; Affiliations: 1: The National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; 2: The National Center for Environmental Health, Atlanta, GA, USA; 3: South Dakota State University, Brookings, SD, USA; Issue Info: Aug2003, Vol. 539 Issue 1/2, p9; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Carcinogenesis; Subject Term: Dry cleaning; Subject Term: Tumors; Author-Supplied Keyword: 8-Hydroxydeoxyguanosine; Author-Supplied Keyword: Oxidative DNA damage; Author-Supplied Keyword: Perchloroethylene; Author-Supplied Keyword: Race; Author-Supplied Keyword: Tobacco smoking; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S1383-5718(03)00130-X
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cherkasova, Elena
AU - Laassri, Majid
AU - Chizhikov, Vladimir
AU - Korotkova, Ekaterina
AU - Dragunsky, Eugenia
AU - Agol, Vadim I.
AU - Chumakov, Konstantin
T1 - Microarray analysis of evolution of RNA viruses: Evidence of circulation of virulent highly divergent vaccine-derived polioviruses.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2003/08/05/
VL - 100
IS - 16
M3 - Article
SP - 9398
EP - 9403
SN - 00278424
AB - Two approaches based on hybridization of viral probes with oligonucleotide microarrays were developed for rapid analysis of genetic variations during microevolution of RNA viruses. Microarray analysis of viral recombination and microarray for resequenclng and heterogeneity analysis were able to generate instant genetic maps of vaccine-derived polioviruses (VDPVs) and reveal the degree of their evolutionary divergence. Unlike conventional methods based on cDNA sequencing and restriction fragment length polymorphism, the microarray approaches are better suited for analysis of heterogeneous populations and mixtures of different strains. The microarray hybridization profile is very sensitive to the cumulative presence of small quantities of different mutations, including those that cannot be revealed by sequencing, making this approach useful for characterization of profiles of nucleotide sequence diversity in viral populations. By using these methods, we identified a type-3 VDPV isolated from a healthy person and missed by conventional methods of screening. The mutational profile of the polio strain was consistent with >1 yr of circulation in human population and was highly virulent in transgenic mice, confirming the ability of VDPV to persist in communities despite high levels of immunity. The proposed methods for fine genotyplng of heterogeneous viral populations can also have utility for a variety of other applications in studies of genetic changes in viruses, bacteria, and genes of higher organisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIOVIRUS
KW - RNA viruses
KW - DNA microarrays
N1 - Accession Number: 10786889; Cherkasova, Elena 1,2 Laassri, Majid 1 Chizhikov, Vladimir 1 Korotkova, Ekaterina 2 Dragunsky, Eugenia 1 Agol, Vadim I. 2,3 Chumakov, Konstantin 1; Email Address: chumakov@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration 2: A.N. Belozersky Institute of Physical-Chemical Biology, Moscow State University 3: M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides Russian Academy of Medical Sciences; Source Info: 8/5/2003, Vol. 100 Issue 16, p9398; Subject Term: POLIOVIRUS; Subject Term: RNA viruses; Subject Term: DNA microarrays; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Badano, Aldo
T1 - Optical blur and collection efficiency in columnar phosphors for X-ray imaging
JO - Nuclear Instruments & Methods in Physics Research Section A
JF - Nuclear Instruments & Methods in Physics Research Section A
Y1 - 2003/08/11/
VL - 508
IS - 3
M3 - Article
SP - 467
SN - 01689002
AB - Columnar phosphors are common in modern indirect X-ray digital imaging systems. However, a comprehensive description of the light scattering processes within such structures has not yet been reported. We present a Monte Carlo analysis of the depth-dependent optical blur and collection efficiency of columnar phosphor screens. We present line-spread (LSF) and modulation transfer (MTF) functions, and optical collection efficiencies for screens with transparent phosphors and different back-layer reflectance. Our phosphor model consists of a uniformly spaced columnar array (9 μm diameter with 1 μm gaps). We present data for single X-ray interactions occurring at varying depths (99, 90, 40, 30, 20, 10, and 1 μm ) for a given screen thickness of 100 μm , and for screens of varying thicknesses (10, 20, 40, 100, 200, and 300 μm ) with exponentially absorbed X-ray beams corresponding to typical mammography spectra. We show quantitatively that depth of interaction and phosphor thickness have a strong effect on LSF and MTF. Our Monte Carlo results are in agreement with published experimentally measured MTF results. The depth-dependent collection efficiency is affected by optical absorption, while being independent of interaction depth and thickness for transparent phosphors. [Copyright &y& Elsevier]
AB - Copyright of Nuclear Instruments & Methods in Physics Research Section A is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHORS
KW - MONTE Carlo method
KW - Line-spread function
KW - Modulation transfer function
KW - Optical blur
KW - Optical gain
KW - Phosphor screens
KW - Resolution
N1 - Accession Number: 10356694; Badano, Aldo 1; Email Address: agb@cdrh.fda.gov; Affiliation: 1: Office of Science and Technology, Center for Devices and Radiological Health, US Food and Drug Administration, 12720 Twinbrook Parkway Mail Shop, HFZ-142, Room 167, Rockville, MD 20857, USA; Source Info: Aug2003, Vol. 508 Issue 3, p467; Subject Term: PHOSPHORS; Subject Term: MONTE Carlo method; Author-Supplied Keyword: Line-spread function; Author-Supplied Keyword: Modulation transfer function; Author-Supplied Keyword: Optical blur; Author-Supplied Keyword: Optical gain; Author-Supplied Keyword: Phosphor screens; Author-Supplied Keyword: Resolution; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0168-9002(03)01651-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ma, Cuiling
AU - Lin, Hong
AU - Leonard, Stephen S
AU - Shi, Xianglin
AU - Ye, Jianping
AU - Luo, Jia
T1 - Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro.
JO - Oncogene
JF - Oncogene
Y1 - 2003/08/14/
VL - 22
IS - 34
M3 - Article
SP - 5281
EP - 5290
PB - Nature Publishing Group
SN - 09509232
AB - Both epidemiological and experimental studies indicate that ethanol is a tumor promoter and may promote metastasis of breast cancer. However, the molecular mechanisms underlying ethanol-mediated tumor promotion remain unknown. Overexpression of ErbB proteins in breast cancer patients is generally associated with poor prognosis. The ErbB proteins are a family of receptor kinases that include four closely related members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. Particularly, ErbB2 plays a pivotal role in ErbB-mediated activities. Here we demonstrated that amplification of ErbB2 expression sensitized a specific cellular response to ethanol. Human breast cancer cells or mammary epithelial cells with a high expression of ErbB2 exhibited an enhanced response to ethanol-stimulated cell invasion in vitro. Ethanol also stimulated cell proliferation; however, this stimulation was independent of ErbB2 levels. Ethanol triggered divergent intracellular signaling among cells expressing different ErbB2 levels. In the cells overexpressing ErbB2, ethanol was more effective in the activation of c-Jun NH2 terminal protein kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK) as well as the induction of reactive oxygen species (ROS) than the cells with normal ErbB2 expression. Blockage of either JNKs or p38 MAPK activation eliminated ethanol-mediated cell invasion. In contrast, the reduction of hydrogen peroxide concentration by catalase exposure had little effect on ethanol-induced cell invasion. These results indicated that ethanol-induced cell invasion was primarily mediated by JNKs and p38 MAPK, whereas the involvement of ROS formation might be minimal. Our study suggests that overexpression of ErbB2 may augment ethanol-elicited signaling and promote ethanol-stimulated tumor metastasis.Oncogene (2003) 22, 5281-5290. doi:10.1038/sj.onc.1206675 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALCOHOL
KW - COCARCINOGENS
KW - METASTASIS
KW - BREAST cancer
KW - EPIDERMAL growth factor
N1 - Accession Number: 10551038; Ma, Cuiling 1 Lin, Hong 2 Leonard, Stephen S 3 Shi, Xianglin 3 Ye, Jianping 4 Luo, Jia 2; Affiliation: 1: [1] 1Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, WV 26506, USA [2] 2Department of Dermatology, Xijing Hospital, Xian 710032, People's Republic of China 2: 1Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, WV 26506, USA 3: 3Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 4: 4Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA; Source Info: 8/14/2003, Vol. 22 Issue 34, p5281; Subject Term: ALCOHOL; Subject Term: COCARCINOGENS; Subject Term: METASTASIS; Subject Term: BREAST cancer; Subject Term: EPIDERMAL growth factor; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1038/sj.onc.1206675
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Engesser, Karl-Heinrich
AU - Cerniglia, Carl E.
T1 - Two polycyclic aromatic hydrocarbon o-quinone reductases from a pyrene-degrading Mycobacterium
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2003/08/15/
VL - 416
IS - 2
M3 - Article
SP - 209
SN - 00039861
AB - Polycyclic aromatic hydrocarbon (PAH) o-quinone reductase (PQR) plays a crucial role in the detoxification of PAH o-quinones by reducing them to catechols. Two constitutive PQRs were found in cell extracts of a pyrene-degrading Mycobacterium sp. strain PYR100. The enzymes had an activity towards 9,10-phenanthrenequinone (PQ) and/or 4,5-pyrenequinone (PyQ), and the relative amounts varied with the pH of the culture media. PQR1, containing an FAD cofactor, was a monomer (20.1 kDa), and PQR2, with no flavin cofactor, was a homodimer (26.5 kDa subunits). There was no homology between the N-terminal sequences of PQR1 and PQR2. Dicumarol and quercetin inhibited PQR2 more strongly than PQR1. PQR1 had much lower specificity constants (kcat/Km , 105 M−1 s−1) for menadione (0.80) and PQ (5.19) than PQR2 (13.9 for menadione and 176 for PQ). Additionally, PQR2 exhibited a broad substrate specificity with high specificity constants for 1,4-naphthalenequinone, 1,2-naphthalenequinone, and PyQ. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROCARBONS
KW - AROMATIC compounds
KW - QUINONE
KW - Degradation
KW - Mycobacterium
KW - PAH o-quinone reductase
KW - Polycyclic aromatic hydrocarbons
N1 - Accession Number: 10352849; Kim, Yong-Hak 1,2 Engesser, Karl-Heinrich 2 Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliation: 1: National Center for Toxicological Research, U.S. FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA 2: Abteilung biologische Abluftreinigung, ISWA, Universität Stuttgart, Stuttgart, Germany; Source Info: Aug2003, Vol. 416 Issue 2, p209; Subject Term: HYDROCARBONS; Subject Term: AROMATIC compounds; Subject Term: QUINONE; Author-Supplied Keyword: Degradation; Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: PAH o-quinone reductase; Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0003-9861(03)00297-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10352849&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schroeder, Carl M.
AU - White, David G.
AU - Ge, Beilei
AU - Zhang, Yifan
AU - McDermott, Patrick F.
AU - Ayers, Sherry
AU - Zhao, Shaohua
AU - Meng, Jianghong
T1 - Isolation of antimicrobial-resistant Escherichia coli from retail meats purchased in Greater Washington, DC, USA
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2003/08/15/
VL - 85
IS - 1/2
M3 - Article
SP - 197
SN - 01681605
AB - Four hundred and seventy-two generic Escherichia coli isolates were recovered from ground and whole retail beef, chicken, pork, and turkey obtained from Greater Washington, DC, USA during the years 1998 to 2000. Many of the isolates displayed resistance to tetracycline (59%), sulfamethoxazole (45%), streptomycin (44%), cephalothin (38%) and ampicillin (35%). Resistance was also observed, but to a lesser extent, to gentamicin (12%), nalidixic acid (8%), chloramphenicol (6%), ceftiofur (4%) and ceftriaxone (1%). Sixteen percent of the isolates displayed resistance to one antimicrobial, followed by 23% to two, 23% to three, 12% to four, 7% to five, 3% to six, 2% to seven and 2% to eight. Three E. coli isolates were shown to possess Shiga toxin genes (stx2) via PCR; all were O non-typeable and were recovered from ground beef samples purchased on the same day at the same supermarket. One of the Shiga toxin-producing E. coli (STEC) isolates was susceptible to each of the antimicrobials tested, whereas one displayed resistance to cephalothin and sulfamethoxazole, and one displayed resistance to ampicillin, cephalothin, gentamicin, streptomycin, sulfamethoxazole and tetracycline. Findings from this study indicate that retail raw meats may often be contaminated with antimicrobial-resistant E. coli. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Escherichia coli
KW - United States
KW - Isolation
KW - Retail meats
N1 - Accession Number: 10009158; Schroeder, Carl M. 1; White, David G. 2; Ge, Beilei 1; Zhang, Yifan 1; McDermott, Patrick F. 2; Ayers, Sherry 2; Zhao, Shaohua 2; Meng, Jianghong 1; Email Address: jm332@umail.umd.edu; Affiliations: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA; 2: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Aug2003, Vol. 85 Issue 1/2, p197; Thesaurus Term: Anti-infective agents; Thesaurus Term: Escherichia coli; Subject: United States; Author-Supplied Keyword: Isolation; Author-Supplied Keyword: Retail meats; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0168-1605(02)00508-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=10009158&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ashley, Kevin
T1 - Developments in electrochemical sensors for occupational and environmental health applications
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
Y1 - 2003/08/15/
VL - 102
IS - 1
M3 - Article
SP - 1
SN - 03043894
AB - This paper provides an overview of recent advances in electrochemical sensors for industrial hygiene monitoring applications. Currently available instrument technologies as well as new devices under development are both exemplified. Progress in ruggedization and miniaturization of electroanalytical devices has led to significant improvements for on-site monitoring applications, e.g. in harsh environments and in biological monitoring. Sensor arrays and modified electrodes offer considerable promise for improved electrochemical sensing, i.e. through multi-species detection and enhanced selectivity. On-site electroanalytical detection and measurement in the field may become more widely used for applications in occupational health monitoring. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hazardous Materials is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - CHEMICAL detectors
KW - ENVIRONMENTAL health
KW - INDUSTRIAL management
KW - MEDICAL care
KW - PUBLIC health
KW - TOXICOLOGY
KW - Electroanalysis
KW - Electrochemical sensors
KW - Industrial hygiene
KW - On-site analysis
N1 - Accession Number: 10742823; Ashley, Kevin 1; Email Address: kashley@cdc.gov; Affiliation: 1: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA; Source Info: Aug2003, Vol. 102 Issue 1, p1; Subject Term: INDUSTRIAL hygiene; Subject Term: CHEMICAL detectors; Subject Term: ENVIRONMENTAL health; Subject Term: INDUSTRIAL management; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Electroanalysis; Author-Supplied Keyword: Electrochemical sensors; Author-Supplied Keyword: Industrial hygiene; Author-Supplied Keyword: On-site analysis; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S0304-3894(03)00198-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10742823&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Drake, Pamela L.
AU - Lawryk, Nicholas J.
AU - Ashley, Kevin
AU - Sussell, Aaron L.
AU - Hazelwood, Kyle J.
AU - Song, Ruiguang
T1 - Evaluation of two portable lead-monitoring methods at mining sites
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
Y1 - 2003/08/15/
VL - 102
IS - 1
M3 - Article
SP - 29
SN - 03043894
AB - Two methods for measuring airborne lead using field-portable instruments have been developed by the National Institute for Occupational Safety and Health (NIOSH): Method 7702 uses X-ray fluorescence (XRF), and Method 7701 employs ultrasonic extraction (UE) followed by anodic stripping voltammetry (ASV). The two portable methods were evaluated at mining sites. Area air samples were collected throughout two mills where ore from nearby mines was processed; the primary constituent of the ore was lead sulfide (galena). The air samples were collected on 37 mm mixed cellulose ester membrane filters housed within plastic filter cassettes. At the end of the work shift, the cassettes were collected and taken to a room off-site for analysis by the two portable methods. The filter samples were first analyzed by XRF and then by UE/ASV. Calibration was verified on both instruments according to standard procedures. The samples were then sent for confirmatory analysis via flame atomic absorption spectrometry (FAAS) according to NIOSH Method 7082. Pairwise comparisons between the methods using the paired t-test showed no statistically significant differences between ASV and FAAS (P>0.05 ); however, the comparison between XRF and FAAS was statistically significant (P<0.05 ). The elevated lead concentrations reported by XRF relative to FAAS were likely the result of the ability of XRF to report total lead, including lead silicates. This form of lead is not liberated in the digestion process prior to FAAS analysis, and is therefore not detected by this method. Despite this discrepancy, lead concentrations measured by both portable technologies were found to be highly correlated with the laboratory method (R2>0.96 ), suggesting that they are suitable as screening methods for airborne lead at mining sites. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hazardous Materials is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VOLTAMMETRY
KW - MINES & mineral resources
KW - GALENA
KW - CELLULOSE
KW - CALIBRATION
KW - SPECTROMETRY
KW - SILICATES
KW - MINERAL industries
KW - Anodic stripping voltammetry
KW - Lead
KW - Portable analysis
KW - Ultrasonic extraction
KW - X-ray fluorescence
N1 - Accession Number: 10742825; Drake, Pamela L. 1; Email Address: pdrake@cdc.gov Lawryk, Nicholas J. 2 Ashley, Kevin 3 Sussell, Aaron L. 3 Hazelwood, Kyle J. 1 Song, Ruiguang 4; Affiliation: 1: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), 315 E. Montgomery Avenue, Spokane, WA 99207, USA 2: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA 3: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, OH 45226, USA 4: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention (NCHSTP), 1600 Clifton Road, NE, Atlanta, GA 30333, USA; Source Info: Aug2003, Vol. 102 Issue 1, p29; Subject Term: VOLTAMMETRY; Subject Term: MINES & mineral resources; Subject Term: GALENA; Subject Term: CELLULOSE; Subject Term: CALIBRATION; Subject Term: SPECTROMETRY; Subject Term: SILICATES; Subject Term: MINERAL industries; Author-Supplied Keyword: Anodic stripping voltammetry; Author-Supplied Keyword: Lead; Author-Supplied Keyword: Portable analysis; Author-Supplied Keyword: Ultrasonic extraction; Author-Supplied Keyword: X-ray fluorescence; NAICS/Industry Codes: 212231 Lead Ore and Zinc Ore Mining; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0304-3894(03)00200-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10742825&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baolin Zhang, Markus
AU - Yaqin Zhang, Markus
AU - Shacter, Emily
T1 - Caspase 3-Mediated Inactivation of Rac GTPases Promotes Drug-Induced Apoptosis in Human Lymphoma Cells.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2003/08/15/
VL - 23
IS - 16
M3 - Article
SP - 5716
SN - 02707306
AB - The Rac members of the Rho family GTPases control signaling pathways that regulate diverse cellular activities, including cytoskeletal organization, gene transcription, and cell transformation. Rac is implicated in apoptosis, but little is known about the mechanism by which it responds to apoptotic stimuli. Here we demonstrate that endogenous Rac GTPases are caspase 3 substrates that are cleaved in human lymphoma cells during drug-induced apoptosis. Cleavage of Rac1 occurs at two unconventional caspase 3 sites, VVGD11/G and VMVD47/G, and results in inactivation of the GTPase and effector functions of the protein (binding to the p21-activated protein kinase PAK1). Expression of caspase 3-resistant Racl mutants in the cells suppresses drug-induced apoptosis. Thus, proteolytic inactivation of Rac GTPases represents a novel, irreversible mechanism of Rac downregulation that allows maximal cell death following drug treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUANOSINE triphosphatase
KW - LYMPHOMAS
N1 - Accession Number: 11091197; Baolin Zhang, Markus 1; Email Address: zhangb@cber.fda.gov Yaqin Zhang, Markus 1 Shacter, Emily 1; Affiliation: 1: Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Biologics, Evaluation and Research, Food and Drug Administration; Source Info: Aug2003, Vol. 23 Issue 16, p5716; Subject Term: GUANOSINE triphosphatase; Subject Term: LYMPHOMAS; Number of Pages: 10p; Illustrations: 13 Black and White Photographs, 2 Diagrams, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Rosemary
AU - Rodriguez, William
AU - Murphy, Dianne
AU - Crescenzi, Terrie
T1 - Pediatric Drug Labeling: Improving the Safety and Efficacy of Pediatric Therapies.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2003/08/20/
VL - 290
IS - 7
M3 - Article
SP - 905
EP - 911
SN - 00987484
AB - Context: Approximately 50% to 75% of drugs used in pediatric medicine have not been studied adequately to provide appropriate labeling information. In 1997, Congress passed the Food and Drug Administration Modernization Act (FDAMA), which encouraged pediatric drug development by providing an incentive in the form of additional marketing exclusivity. Objective: To identify new drug labeling information from pediatric studies submitted to the FDA in response to written requests. Design and Setting: Between July 1998 and April 1, 2002, the FDA requested studies on 242 drugs, and 53 drugs were granted exclusivity. As of January 2003, 49 drugs have new labels. Data from the studies of the first 33 drugs with new pediatric information on the label as of April 2002 are included. Significant labeling information was analyzed along with baseline data and types of studies requested. Main Outcome Measures: Safety data and pediatric information for labeled drugs. Results: There were 53 studies for 33 drug products, 12 (23%) were evaluated for safety only; 23 (43%), safety and efficacy; and 18 (34%), pharmacokinetics and/or pharmacodynamics. Significant new dosing and/or safety information was identified for 12 (36%) drugs. New dosing information was determined for 7 of these drugs. Safety information was defined for gabapentin, propofol, sevoflurane, the combination of ribavirin and interferon alfa-2b, and various betamethasone-containing dermatologic preparations. There was a higher percentage of deaths reported with patients who received propofol compared with controls in the pediatric intensive care unit. Seizures were seen in patients administered sevoflurane. Patients receiving a combination of ribavirin and interferon alfa-2b experienced an increased incidence of suicidal ideation when compared with adults. An unexpectedly high percentage of those receiving betamethasone-containing dermatologic preparations had documented hypopituitary-adrenal axis suppression. Conclus... INSET: Box. Newly Revised Dosing and Safety Information. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRICS
KW - MEDICINE -- Study & teaching
KW - DRUGS
KW - PHARMACOLOGY
KW - LABELING
KW - Betamethasone
KW - Child
KW - Dose-Response Relationship, Drug
KW - Drug Labeling
KW - Gabapentin
KW - Interferon Alfa-2b
KW - Propofol
KW - Ribavirin
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 10612878; Roberts, Rosemary 1 Rodriguez, William 1 Murphy, Dianne 1 Crescenzi, Terrie 1; Affiliation: 1: Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md.; Source Info: 8/20/2003, Vol. 290 Issue 7, p905; Subject Term: PEDIATRICS; Subject Term: MEDICINE -- Study & teaching; Subject Term: DRUGS; Subject Term: PHARMACOLOGY; Subject Term: LABELING; Author-Supplied Keyword: Betamethasone; Author-Supplied Keyword: Child; Author-Supplied Keyword: Dose-Response Relationship, Drug; Author-Supplied Keyword: Drug Labeling; Author-Supplied Keyword: Gabapentin; Author-Supplied Keyword: Interferon Alfa-2b; Author-Supplied Keyword: Propofol; Author-Supplied Keyword: Ribavirin; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106719124
T1 - Pediatric drug labeling: improving the safety and efficacy of pediatric therapies.
AU - Roberts R
AU - Rodriguez W
AU - Murphy D
AU - Crescenzi T
AU - Roberts, Rosemary
AU - Rodriguez, William
AU - Murphy, Dianne
AU - Crescenzi, Terrie
Y1 - 2003/08/20/
N1 - Accession Number: 106719124. Language: English. Entry Date: 20040402. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Budetti PP, Budetti Peter P. Ensuring safe and effective medications for children. (JAMA) 8/20/2003; 290 (7): 950-951. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Drug Labeling -- Evaluation
KW - Drug Therapy -- In Infancy and Childhood
KW - Drugs -- Therapeutic Use -- In Infancy and Childhood
KW - Child
KW - Child, Preschool
KW - Clinical Trials
KW - Descriptive Statistics
KW - Drug Administration
KW - Drug Labeling -- Legislation and Jurisprudence
KW - Drug Monitoring
KW - Drugs -- Pharmacodynamics
KW - Drugs -- Pharmacokinetics
KW - Infant
KW - Patient Safety
KW - Pediatric Care
KW - United States Food and Drug Administration
KW - Human
SP - 905
EP - 911
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 290
IS - 7
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Approximately 50% to 75% of drugs used in pediatric medicine have not been studied adequately to provide appropriate labeling information. In 1997, Congress passed the Food and Drug Administration Modernization Act (FDAMA), which encouraged pediatric drug development by providing an incentive in the form of additional marketing exclusivity.Objective: To identify new drug labeling information from pediatric studies submitted to the FDA in response to written requests.Design and Setting: Between July 1998 and April 1, 2002, the FDA requested studies on 242 drugs, and 53 drugs were granted exclusivity. As of January 2003, 49 drugs have new labels. Data from the studies of the first 33 drugs with new pediatric information on the label as of April 2002 are included. Significant labeling information was analyzed along with baseline data and types of studies requested.Main Outcome Measures: Safety data and pediatric information for labeled drugs.Results: There were 53 studies for 33 drug products, 12 (23%) were evaluated for safety only; 23 (43%), safety and efficacy; and 18 (34%), pharmacokinetics and/or pharmacodynamics. Significant new dosing and/or safety information was identified for 12 (36%) drugs. New dosing information was determined for 7 of these drugs. Safety information was defined for gabapentin, propofol, sevoflurane, the combination of ribavirin and interferon alfa-2b, and various betamethasone-containing dermatologic preparations. There was a higher percentage of deaths reported with patients who received propofol compared with controls in the pediatric intensive care unit. Seizures were seen in patients administered sevoflurane. Patients receiving a combination of ribavirin and interferon alfa-2b experienced an increased incidence of suicidal ideation when compared with adults. An unexpectedly high percentage of those receiving betamethasone-containing dermatologic preparations had documented hypopituitary-adrenal axis suppression.Conclusion: The FDAMA has stimulated pediatric clinical studies resulting in improved understanding of the pharmacokinetics of drugs prescribed in pediatric medicine, important dose changes, and improved safety for children taking certain drugs.
SN - 0098-7484
AD - Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md 20855, USA
AD - Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Metro Park North 1, 7520 Standish Pl, Room 220, Rockville, MD 20855; robertsr@cder.fda.gov
U2 - PMID: 12928467.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106719124&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yaron, Sima
AU - White, David G.
AU - Matthews, Karl R.
T1 - Characterization of an Escherichia coli O157:H7 marR mutant
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2003/08/25/
VL - 85
IS - 3
M3 - Article
SP - 281
SN - 01681605
AB - One mechanism for generation of multiple antibiotic resistance in enteric bacteria involves the global regulatory system marRAB. The operon, when induced, encodes for resistance to structurally and functionally unrelated antibiotics. Exposure of Escherichia coli O157:H7 to increasing levels of chloramphenicol (CHL) resulted in survival of mutants that were resistant to the inducing agent and to tetracycline (TET), nalidixic acid (NAL), and ciprofloxacin (CIP). A mutant (RU122) that lacks MarR, the transcriptional repressor of the multiple antibiotic resistance (mar) operon, served as a genetic tool to study the role of MarR in growth of E. coli O157:H7. No significant difference (P>0.05) was observed in growth curves of the wild-type or the mutant under the conditions examined (rich and minimal media, acidic conditions, and temperatures from 24 to 42 C). A preconditioned mutant (indRU122; cultured for 17 h in Luria–Bertani (LB) containing chloramphenicol and then examined) exhibited greater growth under all treatments tested compared to the mutant. marCRAB of E. coli O157:H7 was sequenced and compared to other known mar sequences to determine divergence from other bacteria (Salmonella, Klebsiella, and Enterobacter). [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibiotics
KW - Bacterial growth
KW - Intestines -- Infections
KW - Operons
KW - Antibiotic resistance
KW - E. coli O157:H7
KW - mar operon
N1 - Accession Number: 10322618; Yaron, Sima 1; White, David G. 2; Matthews, Karl R. 1; Email Address: matthews@aesop.rutgers.edu; Affiliations: 1: Department of Food Science, Cook College, Rutgers, The State University of New Jersey, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA; 2: Division of Animal and Food Microbiology, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Aug2003, Vol. 85 Issue 3, p281; Thesaurus Term: Antibiotics; Thesaurus Term: Bacterial growth; Subject Term: Intestines -- Infections; Subject Term: Operons; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: E. coli O157:H7; Author-Supplied Keyword: mar operon; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0168-1605(02)00547-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Niu, Yamei
AU - Murata, Takashi
AU - Watanabe, Ken
AU - Kawakami, Koji
AU - Yoshimura, Akihiko
AU - Inoue, Jun-ichiro
AU - Puri, Raj K.
AU - Kobayashi, Nobuyuki
T1 - MIP-T3 associates with IL-13Rα1 and suppresses STAT6 activation in response to IL-13 stimulation
JO - FEBS Letters
JF - FEBS Letters
Y1 - 2003/08/28/
VL - 550
IS - 1-3
M3 - Article
SP - 139
SN - 00145793
AB - To unravel the mechanism of interleukin-13 (IL-13)-specific functions, we sought to identify IL-13 receptor (IL-13R) binding molecules. A novel human IL-13Rα1 binding protein (IL13RBP1) has been identified using yeast tri-hybrid system, which was found to encode the same protein as MIP-T3 (microtubule interacting protein that associates with tumor necrosis factor (TNF) receptor associating factor-3 (TRAF3)). It constitutively associates with IL-13Rα1 and suppresses IL-4/13-induced signal transducer and activator of transcription-6 (STAT6) phosphorylation. IL-13-induced STAT6 activation was also inhibited as determined by dual luciferase assay and electrophoretic mobility shift assay (EMSA). These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role. [Copyright &y& Elsevier]
AB - Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKINS
KW - RADIOLIGAND assay
KW - TUMOR necrosis factor
KW - IMMUNOSUPPRESSION
KW - AHR, airway hyperresponsiveness
KW - EMSA, electrophoretic mobility shift assay
KW - IL-13R, interleukin-13 receptor
KW - Interleukin-13
KW - Interleukin-13 receptor-α1 binding protein-1
KW - Interleukin-4
KW - JAK, Janus kinase
KW - Microtubule interacting protein that associates with tumor necrosis factor receptor associating factor-3
KW - MIP-T3, microtubule interacting protein that associates with tumor necrosis factor receptor associating factor-3
KW - Signal transducer and activator of transcription-6
KW - STAT, signal transducer and activator of transcription
KW - TRAF, tumor necrosis factor receptor associating factor
N1 - Accession Number: 10570902; Niu, Yamei 1 Murata, Takashi 1; Email Address: muratat@net.nagasaki-u.ac.jp Watanabe, Ken 1 Kawakami, Koji 2 Yoshimura, Akihiko 3 Inoue, Jun-ichiro 4 Puri, Raj K. 2 Kobayashi, Nobuyuki 1; Affiliation: 1: Division of Molecular Pharmacology of Infectious Agents, Graduate School of Biomedical Science, Nagasaki University, Nagasaki 852-8521, Japan 2: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan 4: Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, Tokyo University, Tokyo 108-8639, Japan; Source Info: Aug2003, Vol. 550 Issue 1-3, p139; Subject Term: INTERLEUKINS; Subject Term: RADIOLIGAND assay; Subject Term: TUMOR necrosis factor; Subject Term: IMMUNOSUPPRESSION; Author-Supplied Keyword: AHR, airway hyperresponsiveness; Author-Supplied Keyword: EMSA, electrophoretic mobility shift assay; Author-Supplied Keyword: IL-13R, interleukin-13 receptor; Author-Supplied Keyword: Interleukin-13; Author-Supplied Keyword: Interleukin-13 receptor-α1 binding protein-1; Author-Supplied Keyword: Interleukin-4; Author-Supplied Keyword: JAK, Janus kinase; Author-Supplied Keyword: Microtubule interacting protein that associates with tumor necrosis factor receptor associating factor-3; Author-Supplied Keyword: MIP-T3, microtubule interacting protein that associates with tumor necrosis factor receptor associating factor-3; Author-Supplied Keyword: Signal transducer and activator of transcription-6; Author-Supplied Keyword: STAT, signal transducer and activator of transcription; Author-Supplied Keyword: TRAF, tumor necrosis factor receptor associating factor; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0014-5793(03)00860-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kovalchuk, Olga
AU - Burke, Paula
AU - Arkhipov, Andrey
AU - Kuchma, Nikolaj
AU - James, S. Jill
AU - Kovalchuk, Igor
AU - Pogribny, Igor
T1 - Genome hypermethylation in Pinus silvestris of Chernobyl—a mechanism for radiation adaptation?
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/08/28/
VL - 529
IS - 1/2
M3 - Article
SP - 13
SN - 00275107
AB - Adaptation is a complex process by which populations of organisms respond to long-term environmental stresses by permanent genetic change. Here we present data from the natural “open-field” radiation adaptation experiment after the Chernobyl accident and provide the first evidence of the involvement of epigenetic changes in adaptation of a eukaryote-Scots pine (Pinus silvestris), to chronic radiation exposure.We have evaluated global genome methylation of control and radiation-exposed pine trees using a method based on cleavage by a methylation-sensitive HpaII restriction endonuclease that leaves a 5′ guanine overhang and subsequent single nucleotide extension with labeled [3H ] dCTP. We have found that genomic DNA of exposed pine trees was considerably hypermethylated. Moreover, hypermethylation appeared to be dependent upon the radiation dose absorbed by the trees. Such hypermethylation may be viewed as a defense strategy of plants that prevents genome instability and reshuffling of the hereditary material, allowing survival in an extreme environment. Further studies are clearly needed to analyze in detail the involvement of DNA methylation and other epigenetic mechanisms in the complex process of radiation stress and adaptive response. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADAPTATION (Biology)
KW - METHYLATION
KW - GENOMES
KW - Chernobyl
KW - Global genome methylation
KW - Pine
KW - Radiation
KW - Stress response
N1 - Accession Number: 10636230; Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca Burke, Paula 1 Arkhipov, Andrey 2 Kuchma, Nikolaj 2 James, S. Jill 3 Kovalchuk, Igor 1 Pogribny, Igor 3; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta., Canada T1K 3M4 2: Chernobyl Scientific and Technical Center of International Research, Shkolnaya Street 6, 255620 Chernobyl, Ukraine 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Aug2003, Vol. 529 Issue 1/2, p13; Subject Term: ADAPTATION (Biology); Subject Term: METHYLATION; Subject Term: GENOMES; Author-Supplied Keyword: Chernobyl; Author-Supplied Keyword: Global genome methylation; Author-Supplied Keyword: Pine; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: Stress response; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0027-5107(03)00103-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saxena, Queen B.
AU - Saxena, Rajiv K.
AU - Siegel, Paul D.
AU - Lewis, Daniel M.
T1 - Identification of organic fractions of diesel exhaust particulate (DEP) which inhibit nitric oxide (NO) production from a murine macrophage cell line
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2003/08/28/
VL - 143
IS - 3
M3 - Article
SP - 317
SN - 03784274
AB - Diesel exhaust particulates (DEPs) can constitute a large component of the particulate air pollution in urban areas and is a health concern. The effects of DEP on nitric oxide (NO) production by a murine macrophage cell line (RAW264.7) in response to interferon-γ (INFγ), lipopolysaccharide, (LPS) and Bacillus Calmette-Guerin (BCG) were studied. The DEP was fractionated into organic and inorganic fractions (carbonaceous core). The organic portion was further divided into asphaltene, saturates, less polar aromatics, more polar aromatics and resins-containing fractions. Each fraction was tested for the ability to suppress NO production from BCG-stimulated macrophages. DEP crude organic extract, more polar aromatic hydrocarbon, and resin fractions dose-dependently inhibited BCG-stimulated NO production. It is concluded that the responsiveness of the macrophages to stimuli, such as BCG, is suppressed by DEP and that this activity is most predominant in the polar aromatic hydrocarbons and resins-containing fractions. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Nitric oxide
KW - Diesel exhaust particulates
KW - Macrophage
N1 - Accession Number: 10119003; Saxena, Queen B. 1,2; Saxena, Rajiv K. 2,3; Siegel, Paul D. 2; Lewis, Daniel M. 2; Email Address: dml1@cdc.gov; Affiliations: 1: Indian Council of Medical Research, New Delhi, India; 2: Analytical Services Branch, HELD, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; 3: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India; Issue Info: Aug2003, Vol. 143 Issue 3, p317; Thesaurus Term: Air pollution; Thesaurus Term: Nitric oxide; Author-Supplied Keyword: Diesel exhaust particulates; Author-Supplied Keyword: Macrophage; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0378-4274(03)00192-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cho, HyeYoung
AU - Lee, JooYong
AU - Kwak, Noh-Jin
AU - Lee, Kweon-Haeng
AU - Rha, SukJoo
AU - Kim, Young-Hoon
AU - Cho, Yong-Yeun
AU - Yang, Ki-Hwa
AU - Kim, KyoungAh
AU - Lim, Young
T1 - Silica induces nuclear factor-κB activation through TAK1 and NIK in Rat2 cell line
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2003/08/28/
VL - 143
IS - 3
M3 - Article
SP - 323
SN - 03784274
AB - Silica has been known to be a factor in acute cell injury and chronic pulmonary fibrosis. In Rat2 fibroblasts, silica induced the activation of nuclear factor-kappa B (NF-κB), which plays a crucial role in regulating the expression of many genes involved in the subsequent inflammatory response. In addition, we observed that transforming growth factor-β activated kinase 1 (TAK1) and NF-κB-inducing kinase (NIK) were involved in silica-mediated NF-κB activation in Rat2 cells. The dominant negative mutant forms of TAK1 and NIK inhibited the silica-induced NF-κB activation in Rat2 cells. Furthermore, we demonstrated that endogenous TAK1 is phosphorylated in silica-stimulated Rat2 cells. These results indicate that TAK1 functions as a critical mediator in the silica-induced signaling pathway. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silica
KW - Pulmonary fibrosis
KW - IKK, IκB kinase
KW - MAPKKK, mitogen-activated protein kinase kinase kinase
KW - NF-κB
KW - NF-κB, nuclear factor-kappa B
KW - NIK
KW - NIK, NF-κB-inducing kinase
KW - Rat2 cells
KW - TAK1
KW - TAK1, transforming growth factor-β activated kinase 1
N1 - Accession Number: 10119004; Cho, HyeYoung 1; Lee, JooYong 2; Kwak, Noh-Jin 2; Lee, Kweon-Haeng 2,3; Rha, SukJoo 2; Kim, Young-Hoon 2; Cho, Yong-Yeun 4; Yang, Ki-Hwa 4; Kim, KyoungAh 1; Lim, Young 1,5; Email Address: nglim@catholic.ac.kr; Affiliations: 1: Department of Occupational and Environmental Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 2: Research Institute of New Drug Development, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 3: Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 4: Korea Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea; 5: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; Issue Info: Aug2003, Vol. 143 Issue 3, p323; Subject Term: Silica; Subject Term: Pulmonary fibrosis; Author-Supplied Keyword: IKK, IκB kinase; Author-Supplied Keyword: MAPKKK, mitogen-activated protein kinase kinase kinase; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: NF-κB, nuclear factor-kappa B; Author-Supplied Keyword: NIK; Author-Supplied Keyword: NIK, NF-κB-inducing kinase; Author-Supplied Keyword: Rat2 cells; Author-Supplied Keyword: TAK1; Author-Supplied Keyword: TAK1, transforming growth factor-β activated kinase 1; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0378-4274(03)00193-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Wynne, Rebecca
AU - Heinze, Thomas M.
AU - Paine, Donald D.
T1 - Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2003/08/29/
VL - 225
IS - 2
M3 - Article
SP - 195
SN - 03781097
AB - Enterococcus casseliflavus and Enterococcus gallinarum strains resistant to metronidazole, nitrofurantoin and nitrofurazone were isolated from fecal samples of a patient with recurrent ulcerative colitis treated with metronidazole. Unlike other metronidazole-resistant bacteria, these strains produced nitroreductase but metabolized metronidazole to compounds that could not be detected by liquid chromatography with UV or mass spectral analysis. Metronidazole-susceptible Clostridium perfringens grew equally well in spent cultures of Enterococcus spp. incubated with or without metronidazole. These data indicate that the nitroreductases produced by these Enterococcus strains did not activate metronidazole to bactericidal metabolites and these bacteria may reduce the effectiveness of metronidazole. We have indirect evidence for an alternative pathway that results in metronidazole resistance. These strains of enterococcus had nitroreductase so resistance should not have occurred. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metronidazole
KW - Enterococcus
KW - Ulcerative colitis
KW - Intestinal bacteria
KW - Nitroreductase
N1 - Accession Number: 10695896; Rafii, Fatemeh 1; Email Address: frafii@nctr.fda.gov; Wynne, Rebecca 1; Heinze, Thomas M. 2; Paine, Donald D. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; 2: Division of Chemistry, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Issue Info: Aug2003, Vol. 225 Issue 2, p195; Subject Term: Metronidazole; Subject Term: Enterococcus; Subject Term: Ulcerative colitis; Author-Supplied Keyword: Intestinal bacteria; Author-Supplied Keyword: Nitroreductase; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0378-1097(03)00513-5
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Avigan, Mark
AU - Justice, Robert
AU - Mackey, Ann Corken
AU - Nair, Narayan
T1 - Re: Brandt et al. An evidence-based approach to the management of irritable bowel syndrome in North America11 Disclaimer: No direct support was received for this manuscript. The views expressed are those of the authors and do not necessarily represent those of, nor imply endorsement from, the U.S. Food and Drug Administration or the U.S. government.1 Also known as Nucleic acid Amplification Testing or Technology.a )pyrene-7,8-dihydrodiol-9,10-epoxide (N2-dG-BPDE); N6-deoxyadenosine-benzo(a )pyrene-7,8-dihydrodiol-9,10-epoxide (N6-dA-BPDE), and N4-deoxycytidine-benzo(a )pyrene-7,8-dihydrodiol-9,10-epoxide (N4-dC-BPDE) were identified. The concentrations of N2-dG-BPDE, N6-dA-BPDE, and N4-dC-BPDE adducts were determined to be 1.17, 0.97, and 0.68 pmol/mg DNA, respectively, in the lung tissue of exposed mice using the nanoflow technique. The total DNA adducts in exposed lung tissue was determined to be 8.35 pmol/mg DNA by 32P-postlabeling assay. In total, the results indicated that PAH–DNA adducts were significantly elevated (p<0.001 ) in the lung tissue of asphalt-fume-exposed mice relative to tissue from control animals. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - DNA
KW - HYDROCARBONS
KW - QUADRUPOLES
KW - DNA adducts
KW - LC/quadrupole time-of-flight MS
KW - Nanoflow
N1 - Accession Number: 10922735; Wang, Jin J. 1; Email Address: juw9@cdc.gov Marshall, William D. 2 Frazer, David G. 1 Law, Brandon 1 Lewis, Daniel M. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Morgantown, WV 26505, USA 2: Department of Food Science and Agricultural Chemistry, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Canada H9X 3V9; Source Info: Nov2003, Vol. 322 Issue 1, p79; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: DNA; Subject Term: HYDROCARBONS; Subject Term: QUADRUPOLES; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: LC/quadrupole time-of-flight MS; Author-Supplied Keyword: Nanoflow; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ab.2003.07.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=10922735&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jin J. Wang
AU - Frazer, David G.
AU - Stone, Samuels
AU - Goldsith, Travis
AU - Law, Brandon
AU - Moseley, Amy
AU - Simpson, Janet
AU - Afshari, Ali
AU - Lewis, Daniel M.
T1 - Urinary Benzo[a]pyrene and Its Metabolites as Molecular Biomarkers of Asphalt Fume Exposure Characterized by Microflow LC Coupled to Hybrid Quadrupole Time-of-Flight Mass Spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2003/11//11/1/2003
VL - 75
IS - 21
M3 - Article
SP - 5953
EP - 5960
SN - 00032700
AB - As a step to study the health effects of asphalt fume exposure, an analytical method was developed to characterize benzo[a]pyrene and its hydroxy metabolites in the urine of asphalt fume-exposed rats. This method is based on microflow liquid chromatography (LC) coupled to hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometry (Q-TOFMS). Twenty-four female Sprague-Dawley rats were used in the experiment, with 8 as controls and 16 exposed to asphalt fumes in a whole-body inhalation chamber for 10 days (4 h/day). Generated at 150°C, the asphalt fume concentration in the animal exposure chamber ranged 76-117 mg/m[SUP3]. In the urine of the asphalt fume-exposed rats, benzo[a]pyrene and its metabolites of 3-hydroxybenzo[a]pyrene, benzo[a]pyrene7,8-dihydrodiol(±), and benzo[a]pyrene-7,8,9,10-tetrahydrotetrol(±) were identified, and their concentrations were determined at 2.19 ± 0.49, 16.17 ± 0.3, 6.28 ± 0.36, and 29.35 ± 0.26 ng/100 mL, respectively. The metabolite concentrations from the controlled group, however, were either under the detection limits or at a relatively very low level (0.19 ± 0.41 ng/100 mL for benzo[a]pyrene-7,8,9,10-tetrahydrotetrol metabolite). The results clearly indicate that the benzo[a]pyrene and its hydroxy metabolites were significantly elevated (p < 0.001) in the urine of asphalt fume-exposed rats relative to controls. The study also demonstrated that the combination of microflow LC separation and collision-induced dissociation leading to a characteristic fragmentation pattern by hybrid Q-TOFMS offers a distinct advantage for the identifications and characterizations of the benzo[a]pyrene metabolites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - ASPHALT
KW - LIQUID chromatography
KW - QUADRUPOLES
KW - TIME-of-flight mass spectrometry
N1 - Accession Number: 11425054; Jin J. Wang 1; Email Address: juw9@cdc.gov Frazer, David G. 1 Stone, Samuels 1 Goldsith, Travis 1 Law, Brandon 1 Moseley, Amy 1 Simpson, Janet 1 Afshari, Ali 1 Lewis, Daniel M. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , U.S. Department of Health and Human Services, Morgantown, West Virginia 26505; Source Info: 11/1/2003, Vol. 75 Issue 21, p5953; Subject Term: BIOCHEMICAL markers; Subject Term: ASPHALT; Subject Term: LIQUID chromatography; Subject Term: QUADRUPOLES; Subject Term: TIME-of-flight mass spectrometry; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1021/ac030017a
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Glaser, Robert A.
AU - Shulman, Stanley
AU - Kurimo, Robert
AU - Piacitelli, Greg
T1 - An Evaluation of ASTM Method P-42-97 for Sampling and Analysis of Metalworking Fluids.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2003/11//
VL - 18
IS - 11
M3 - Article
SP - 825
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Evaluates the method P-42-97, used for sampling and analysis of metal-working fluids. Standards for testing metal-working fluids set by the U.S.-based American Society for Testing and Materials; Recommended exposure limit for metal-working fluids.
KW - Occupational diseases
KW - Metalworking lubricants
KW - Lubrication & lubricants
KW - Metalwork
KW - ASTM Analytical Method
KW - Fraction Extracted
KW - Limits of Detection and Quantitation
KW - Metalworking Fluids
N1 - Accession Number: 11093548; Glaser, Robert A. 1; Shulman, Stanley 1; Kurimo, Robert 1; Piacitelli, Greg 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Issue Info: Nov2003, Vol. 18 Issue 11, p825; Thesaurus Term: Occupational diseases; Subject Term: Metalworking lubricants; Subject Term: Lubrication & lubricants; Subject Term: Metalwork; Author-Supplied Keyword: ASTM Analytical Method; Author-Supplied Keyword: Fraction Extracted; Author-Supplied Keyword: Limits of Detection and Quantitation; Author-Supplied Keyword: Metalworking Fluids; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10473220390237322
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trout, Douglas
AU - Weissman, David N.
AU - Lewis, Daniel
AU - Brundage, Rodney A.
AU - Franzblau, Alfred
AU - Remick, Daniel
T1 - Evaluation of Hypersensitivity Pneumonitis Among Workers Exposed to Metal Removal Fluids.
JO - Applied Occupational & Environmental Hygiene
JF - Applied Occupational & Environmental Hygiene
Y1 - 2003/11//
VL - 18
IS - 11
M3 - Article
SP - 953
PB - Taylor & Francis Ltd
SN - 1047322X
AB - Hypersensitivity pneumonitis (HP) was identified among employees in an automobile parts manufacturing facility. Mycobacteria immunogenum (MI) was identified as a metal removal fluid (MRF) contaminant at this facility and had been identified as a contaminant in other facilities where HP had occurred. We therefore questioned whether measurement of MI-specific cell-mediated immunity would be associated with HP in this facility. We also questioned whether measures of cell-mediated immunity would be more informative about the presence of HP than evaluation of serum anti-MI antibody levels. Workers were categorized for exposure and disease status by questionnaire and review of medical records. Cell-mediated immunity to MI was assessed by measuring in vitro secretion of cytokines (interleukin 8, tumor necrosis factor alpha, and interferon-γ) from peripheral blood mononuclear cells or anticoagulated whole blood induced by culture with MI antigen. Serum antibodies against MI were also measured. Six study participants met our survey definition for HP and 48 did not. As has been reported for various agents causing HP, serum antibody levels against MI were increased in both exposed workers and workers with HP. Serum antibodies did not distinguish between the two. When expressed as a percentage of secretion induced by lipopolysaccharide, MI induced a significant increase in interleukin-8 secretion in exposed participants' whole blood cultures. There were trends for increased MI-induced secretion of interferon-γ by peripheral blood mononuclear cells from both exposed workers and workers with HP. However, these trends did not attain statistical significance. Thus, several measures of immunity to MI distinguished between exposed and unexposed workers but not between workers with and without HP. These evaluations of cell-mediated immunity were not more informative than measurement of serum antibodies. As was done at this facility, institution of a comprehensive safety and health plan for MRF is necessary to eliminate (or minimize) health effects related to occupational exposures in the machining environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacterium
KW - Pneumonia
KW - Metalworking lubricants
KW - Machining
KW - Coolant
KW - Hypersensitivity Pneumonitis
KW - Metal Removal Fluids
KW - Metalworking Fluids
KW - Mycobacterium Immunogenum
N1 - Accession Number: 11093538; Trout, Douglas 1; Weissman, David N. 2; Lewis, Daniel 2; Brundage, Rodney A. 2; Franzblau, Alfred 3,4; Remick, Daniel 4; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia.; 3: University of Michigan School of Public Health, Ann Arbor, Michigan.; 4: University of Michigan Medical School, Ann Arbor, Michigan.; Issue Info: Nov2003, Vol. 18 Issue 11, p953; Subject Term: Mycobacterium; Subject Term: Pneumonia; Subject Term: Metalworking lubricants; Subject Term: Machining; Author-Supplied Keyword: Coolant; Author-Supplied Keyword: Hypersensitivity Pneumonitis; Author-Supplied Keyword: Metal Removal Fluids; Author-Supplied Keyword: Metalworking Fluids; Author-Supplied Keyword: Mycobacterium Immunogenum; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10473220390237683
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106729851
T1 - Are means meaningless? The application of individual responder analysis to analgesic drug development.
AU - Witter J
AU - Simon LS
AU - Dionne R
Y1 - 2003/11//2003 Nov-Dec
N1 - Accession Number: 106729851. Language: English. Entry Date: 20040430. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. NLM UID: 9315090.
KW - Analgesics -- Therapeutic Use
KW - Chronic Pain -- Drug Therapy
KW - Clinical Trials
KW - Outcome Assessment
KW - Pain Measurement
KW - Research Methodology
KW - Age Factors
KW - Clinical Assessment Tools
KW - Dependent Variable
KW - Descriptive Statistics
KW - Dose-Response Relationship, Drug
KW - Female
KW - Male
KW - Morphine -- Administration and Dosage
KW - Pain -- Familial and Genetic
KW - Pain -- Physiopathology
KW - Sex Factors
KW - Visual Analog Scaling
SP - 1
EP - 7
JO - APS Bulletin
JF - APS Bulletin
JA - APS BULL
VL - 13
IS - 6
CY - Glenview, Illinois
PB - American Pain Society
SN - 1057-1590
AD - Clinical Team Leader, Division of Analgesics, Anti-inflammatory, and Ophthalmic Drug Products, Center for Drug Evaluation and Research (CDER), FDA
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Snyder, J. C.
AU - Thacker, R. R.
AU - Boeniger, M.
AU - Antonious, G. F.
T1 - Potential of Solid Phase Extraction Disks to Aid Determination of Dislodgeable Foliar Residues of Chlorpyriphos, Malathion, Diazinon, and Acephate.
JO - Archives of Environmental Contamination & Toxicology
JF - Archives of Environmental Contamination & Toxicology
Y1 - 2003/11//
VL - 45
IS - 4
M3 - Article
SP - 429
EP - 435
PB - Springer Science & Business Media B.V.
SN - 00904341
AB - The utility of solid phase extraction (SPE) for concentrating four organophosphate insecticides from solutions of water and sodium dioctyl sulfosuccinate, a surfactant, was evaluated. Reverse phase (C18, octadecyl bonded silica) sorbent in the form of a disk was the SPE medium evaluated. Chlorpyriphos, malathion, and diazinon, but not acephate, were retained on and eluted from the SPE disks. For pesticides that were retained on SPE disks, recoveries from the disks were equal to or higher than recoveries achieved by solvent partitioning. Dislodgeable foliar residues of acephate were successfully concentrated for analysis by lyophilization of water–surfactant solutions. Recoveries of pesticides from SPE disks stored at -15°C for one week were equal to or higher than those of pesticides stored in water–surfactant for one week at -15°C. Malathion- and diazinon-fortified samples in water–surfactant and on SPE disks were prepared in one state and shipped for analysis in another state. Pesticides in the water–surfactant samples were concentrated by solvent partitioning and were underestimated by 41% (diazinon) and 16% (malathion). Conversely, diazinon samples on the SPE disks were on average underestimated by 3% and malathion was overestimated by an average of 55%. The overestimation of malathion was attributed to a matrix effect during analysis associated with the presence of surfactant, which was retained on and subsequently eluted from the SPE disks. The retention of surfactant by the SPE disks and its subsequent elution may considerably limit their usefulness in determination of dislodgeable foliar residues. RID="" ID="" Correspondence to: J. C. Snyder; email: snyder@uky.edu [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pesticides
KW - Extraction techniques
KW - Pests -- Control
KW - Agricultural chemicals
KW - Silicon compounds
KW - Organophosphorus compounds
N1 - Accession Number: 16654520; Snyder, J. C. 1; Email Address: snyder@uky.edu; Thacker, R. R. 1; Boeniger, M. 2; Antonious, G. F. 3; Affiliations: 1: Department of Horticulture, University of Kentucky, N318 Agricultural Science North, Lexington, Kentucky 40546, USA.; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio 25226, USA, USA.; 3: Community Research Service, Kentucky State University, Frankfort, Kentucky 40601, USA.; Issue Info: Nov2003, Vol. 45 Issue 4, p429; Thesaurus Term: Pesticides; Thesaurus Term: Extraction techniques; Thesaurus Term: Pests -- Control; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Silicon compounds; Subject Term: Organophosphorus compounds; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s00244-003-2121-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16654520&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sang Hyun Kim
AU - Johnson, Victor J.
AU - Sharma, Raghubir P.
T1 - Oral exposure to inorganic mercury alters T lymphocyte phenotypes and cytokine expression in BALB/c mice.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2003/11//
VL - 77
IS - 11
M3 - Article
SP - 613
EP - 620
SN - 03405761
AB - Mercury is a well-recognized health hazard and an environmental contaminant. Mercury modulates immune responses ranging from immune suppression to autoimmunity but the mechanisms responsible for these effects are still unclear. Male BALB/c mice were exposed continuously to 0, 0.3, 1.5, 7.5, or 37.5 ppm mercury in drinking water for 14 days. Body weight was reduced at the highest dose of mercury whereas the relative kidney and spleen weights were significantly increased. The dose range of mercury used did not cause hepatotoxicity as indicated by circulating alanine aminotransferase and aspartate aminotransferase levels. Circulating blood leukocytes were elevated in mice treated with the highest dose of mercury. Mercury ranging from 1.5 to 37.5 ppm dose-dependently decreased CD3+ T lymphocytes in spleen; both CD4+ and CD8+ single-positive lymphocyte populations were decreased. Exposure to 7.5 and 37.5 ppm mercury decreased the CD8+ T lymphocyte population in the thymus, whereas double-positive CD4+/CD8+ and CD4+ thymocytes were not altered. Mercury altered the expression of inflammatory cytokines (tumor necrosis factor α, interferon γ, and interleukin-12), c-myc, and major histocompatibility complex II, in various organs. Results indicated that a decrease in T lymphocyte populations in immune organs and altered cytokine gene expression may contribute to the immunotoxic effects of inorganic mercury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MERCURY poisoning
KW - HEALTH risk assessment
KW - T cells
KW - CYTOKINES
KW - POLLUTION
KW - CONTAMINATION (Technology)
KW - Drinking water
KW - Immunotoxicity
KW - Inflammatory cytokines
KW - Major histocompatibility complex II
KW - Mercury
KW - T lymphocytes
N1 - Accession Number: 16983657; Sang Hyun Kim 1,2 Johnson, Victor J. 1,3 Sharma, Raghubir P. 1; Email Address: rpsharma@vet.uga.edu; Affiliation: 1: Interdisciplinary Program of Toxicology, Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602-7389, USA 2: Laboratory of Molecular Immunoregulation, NCI, National Institutes of Health, Frederick, MD 21702, USA 3: Toxicology and Molecular Biology Branch, National Institute of Occupational Safety and Health, CDC, Morgantown, WV 26505, USA; Source Info: Nov2003, Vol. 77 Issue 11, p613; Subject Term: MERCURY poisoning; Subject Term: HEALTH risk assessment; Subject Term: T cells; Subject Term: CYTOKINES; Subject Term: POLLUTION; Subject Term: CONTAMINATION (Technology); Author-Supplied Keyword: Drinking water; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Inflammatory cytokines; Author-Supplied Keyword: Major histocompatibility complex II; Author-Supplied Keyword: Mercury; Author-Supplied Keyword: T lymphocytes; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/s00204-003-0497-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haverkos, Harry W.
AU - Battula, Narayana
AU - Drotman, D. Peter
AU - Rennert, Owen M.
T1 - Enteroviruses and type 1 diabetes mellitus
JO - Biomedicine & Pharmacotherapy
JF - Biomedicine & Pharmacotherapy
Y1 - 2003/11//
VL - 57
IS - 9
M3 - Article
SP - 379
SN - 07533322
AB - Despite decades of research, the etiology of type 1 diabetes mellitus (DM) is unknown. Several risk factors have been associated with type 1 DM, including viral infections, genetic predisposition, nutritional factors, and chemicals. Several investigators hypothesize that the etiologies of type 1 DM result from a complex interaction of genetic and environmental factors. In this paper we review the epidemiologic data linking enteroviruses to type 1 DM and discuss potential mechanisms of pathogenesis. [Copyright &y& Elsevier]
AB - Copyright of Biomedicine & Pharmacotherapy is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - DISEASES -- Causes & theories of causation
KW - ENTEROVIRUSES
KW - DISEASES -- Risk factors
KW - Cofactors
KW - Enterovirus
KW - Type 1 diabetes mellitus
N1 - Accession Number: 11537379; Haverkos, Harry W. 1; Email Address: haverkosh@cder.fda.gov Battula, Narayana 1 Drotman, D. Peter 2 Rennert, Owen M. 3; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, HFD-530, 5600 Fishers Lane, Rockville, MD 20857, USA 2: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA 3: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Source Info: Nov2003, Vol. 57 Issue 9, p379; Subject Term: DIABETES; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: ENTEROVIRUSES; Subject Term: DISEASES -- Risk factors; Author-Supplied Keyword: Cofactors; Author-Supplied Keyword: Enterovirus; Author-Supplied Keyword: Type 1 diabetes mellitus; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biopha.2003.03.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Molinda, Gregory M.
AU - Robertson, Susan B.
AU - Mark, Christopher
AU - Dolinar, Dennis R.
T1 - COVERING THE ROOF.
JO - Coal Age
JF - Coal Age
Y1 - 2003/11//Nov/Dec2003
VL - 108
IS - 10
M3 - Article
SP - 20
EP - 26
PB - Mining Media Inc.
SN - 10407820
AB - Discusses the application of steel screen in covering the roof of underground coal mines. Injuries and death caused by roof falls in underground coal mines; Roof support products available in the market; Benefits of steel screen.
KW - MINE safety
KW - COAL mines & mining
KW - COAL industry
KW - MINE roof bolting
KW - GROUND control (Mining)
N1 - Accession Number: 11988015; Molinda, Gregory M. 1; Robertson, Susan B. 2; Mark, Christopher 3; Dolinar, Dennis R. 2; Affiliations: 1: Research geologist, National Institute for Occupational Safety and Health at the Pittsburgh Research Laboratory; 2: Mining engineer, National Institute for Occupational Safety and Health at the Pittsburgh Research Laboratory; 3: Chief, rock mechanics, National Institute for Occupational Safety and Health at the Pittsburgh Research Laboratory; Issue Info: Nov/Dec2003, Vol. 108 Issue 10, p20; Thesaurus Term: MINE safety; Thesaurus Term: COAL mines & mining; Thesaurus Term: COAL industry; Subject Term: MINE roof bolting; Subject Term: GROUND control (Mining); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 4p; Illustrations: 5 Color Photographs, 2 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 2539
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Lawrence, William F.
AU - Clancy, Carolyn M.
T1 - Health Outcomes Assessment in Cancer: Current Measurement Strategies and Recommendations for Improvement.
JO - Disease Management & Health Outcomes
JF - Disease Management & Health Outcomes
Y1 - 2003/11//
VL - 11
IS - 11
M3 - Article
SP - 709
EP - 721
PB - Springer Science & Business Media B.V.
SN - 11738790
AB - Measuring the outcomes of cancer care has become increasingly important both in clinical practice and in health policy. Responsiveness to patient-centered needs, preferences, and outcomes is one of the hallmarks of quality healthcare. Health-related quality of life (HR-QOL) measures can be considered within a framework based upon: (i) whether the measure is a generic instrument applicable across a wide range of health conditions, or whether it is specific to cancer or a specific cancer site; (ii) whether it measures a single domain of health or multiple domains; and (iii) whether or not the measure is preference based. Judicious selection of a set of instruments from within different areas of this framework can provide a detailed description of relevant aspects of a patient’s health for a wide variety of research and clinical needs. Current health outcomes research is focused not only on the development of improved measures of health, but also on how to expand the use of these measures from research settings into clinical practice and health policy in ways to improve the process and outcomes of cancer care. Shared decision-making tools incorporating HR-QOL data can assist patients in clarifying decision alternatives for difficult cancer treatment decisions. Observational studies of HR-QOL of cancer patients can help patients better understand potential outcomes of their choices. HR-QOL measures are being used in quality of care initiatives. Cancer care is composed of a spectrum of services, ranging from prevention and early detection, through to diagnosis and treatment, as well as end-of-life care. As the importance of the patient’s perspective has become more clearly recognized, health outcomes measures have become more widely used and can contribute to improved care across the spectrum of cancer services. While further research needs to focus on developing better measures of health, it is equally imperative that future research focus on methods to incorporate health outcomes measurement into practice in ways to improve clinical practice, health policy, and ultimately to improve the outcomes of care of patients with cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Disease Management & Health Outcomes is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL screening
KW - CANCER patients
KW - MEDICAL care
KW - QUALITY of life
KW - METHODOLOGY
KW - Cancer, assessment
KW - Outcomes research
KW - Quality of life
N1 - Accession Number: 11581378; Lawrence, William F. 1; Email Address: wlawrenc@ahrq.gov Clancy, Carolyn M. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Rockville, Maryland, USA; Source Info: Nov2003, Vol. 11 Issue 11, p709; Subject Term: MEDICAL screening; Subject Term: CANCER patients; Subject Term: MEDICAL care; Subject Term: QUALITY of life; Subject Term: METHODOLOGY; Author-Supplied Keyword: Cancer, assessment; Author-Supplied Keyword: Outcomes research; Author-Supplied Keyword: Quality of life; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106568455
T1 - Health outcomes assessment in cancer: current measurement strategies and recommendations for improvement.
AU - Lawrence WF
AU - Clancy CM
Y1 - 2003/11//
N1 - Accession Number: 106568455. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Instrumentation: Functional Assessment of Cancer Therapy-General (FACT-G); Short Form-36 Health Survey (SF-36); Dartmouth Primary Care Cooperative Information Project (COOP) chart system; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30); Nottingham Health Profile (NHP); Short Form 12 Health Survey (SF-12). NLM UID: 9704215.
KW - Neoplasms -- Therapy
KW - Oncologic Care -- Trends
KW - Quality of Life -- Evaluation
KW - Treatment Outcomes -- Evaluation
KW - Consumer Participation
KW - Decision Making, Patient
KW - Research Instruments
KW - Scales
KW - Short Form-36 Health Survey (SF-36)
KW - Sickness Impact Profile
SP - 709
EP - 721
JO - Disease Management & Health Outcomes
JF - Disease Management & Health Outcomes
JA - DIS MANAGE HEALTH OUTCOMES
VL - 11
IS - 11
PB - Springer Science & Business Media B.V.
AB - Measuring the outcomes of cancer care has become increasingly important both in clinical practice and in health policy. Responsiveness to patient-centered needs, preferences, and outcomes is one of the hallmarks of quality healthcare.Health-related quality of life (HR-QOL) measures can be considered within a framework based upon: (i) whether the measure is a generic instrument applicable across a wide range of health conditions, or whether it is specific to cancer or a specific cancer site; (ii) whether it measures a single domain of health or multiple domains; and (iii) whether or not the measure is preference based. Judicious selection of a set of instruments from within different areas of this framework can provide a detailed description of relevant aspects of a patient's health for a wide variety of research and clinical needs.Current health outcomes research is focused not only on the development of improved measures of health, but also on how to expand the use of these measures from research settings into clinical practice and health policy in ways to improve the process and outcomes of cancer care. Shared decision-making tools incorporating HR-QOL data can assist patients in clarifying decision alternatives for difficult cancer treatment decisions. Observational studies of HR-QOL of cancer patients can help patients better understand potential outcomes of their choices. HR-QOL measures are being used in quality of care initiatives.Cancer care is composed of a spectrum of services, ranging from prevention and early detection, through to diagnosis and treatment, as well as end-of-life care. As the importance of the patient's perspective has become more clearly recognized, health outcomes measures have become more widely used and can contribute to improved care across the spectrum of cancer services. While further research needs to focus on developing better measures of health, it is equally imperative that future research focus on methods to incorporate health outcomes measurement into practice in ways to improve clinical practice, health policy, and ultimately to improve the outcomes of care of patients with cancer.
SN - 1173-8790
AD - Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, 6010 Executive Blvd, Suite 300, MD 20852; wlawrenc@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Simeonova, Petia P.
AU - Hulderman, Tracy
AU - Harki, Dan
AU - Luster, Michael I.
T1 - Arsenic Exposure Accelerates Atherogenesis in Apolipoprotein E[sup-/-] Mice.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003/11//
VL - 111
IS - 14
M3 - Article
SP - 1744
EP - 1748
PB - Superintendent of Documents
SN - 00916765
AB - Determines whether arsenic exposure influences the progression of atherosclerotic plaque formation in apolipoprotein-E mice. Effects of arsenic on molecular events relevant to the major pathogenic mechanisms of atherosclerosis in reference to human vascular cell culture systems; Increase in the size of lesions covering the intimal area of the aorta in arsenic-treated apolipoprotein-E mice compared with non-treated transgenic mice; Role of the induction of endothelial inflammatory activity in arsenic-related vascular effects.
KW - Mice
KW - Atherosclerosis
KW - Arsenic in the body
KW - Apolipoprotein E
N1 - Accession Number: 11555827; Simeonova, Petia P. 1; Email Address: psimeonova@cdc.gov; Hulderman, Tracy 1; Harki, Dan 1; Luster, Michael I. 1; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Nov2003, Vol. 111 Issue 14, p1744; Thesaurus Term: Mice; Subject Term: Atherosclerosis; Subject Term: Arsenic in the body; Subject Term: Apolipoprotein E; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Illustrations: 1 Color Photograph, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weissman, Joel S.
AU - Moy, Ernest
AU - Campbell, Eric G.
AU - Gokhale, Manjusha
AU - Yucel, Recai
AU - Causino, Nancyanne
AU - Blumenthal, David
T1 - Limits To The Safety Net: Teaching Hospital Faculty Report On Their Patients' Access To Care.
JO - Health Affairs
JF - Health Affairs
Y1 - 2003/11//Nov/Dec2003
VL - 22
IS - 6
M3 - Article
SP - 156
EP - 166
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Many major teaching hospitals might not be able to offer adequate access to specialty care for uninsured patients. This study found that medical school faculty were more likely to have difficulty obtaining specialty services for uninsured than for privately insured patients. These gaps in access were similar in magnitude for public and private institutions. Initial treatment of uninsured patients at academic health centers (AHCs) does not guarantee access to specialty and other referral services, which suggests that there are limits to relying on a health care safety net for uninsured patients. AHCs and affiliated group practices should examine policies that limit access for uninsured patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEACHING hospitals
KW - MEDICALLY uninsured persons
KW - ACADEMIC medical centers
KW - MEDICAL care
KW - HOSPITALS
N1 - Accession Number: 11541040; Weissman, Joel S. 1 Moy, Ernest 2 Campbell, Eric G. 3 Gokhale, Manjusha 4 Yucel, Recai 5 Causino, Nancyanne 5 Blumenthal, David 6; Affiliation: 1: Associate Professor, Department of Medicine at Harvard Medical School and the Institute for Health Policy at Massachusetts General Hospital 2: Senior Research Scientist at the Agency for Healthcare Research and Quality in Rockville, Maryland 3: Asssitant Professor, Department of Medicine at Harvard Medical School and the Institute for Health Policy at Massachusetts General Hospital 4: Senior Programmer/analyst at the Institute for Health Policy at Massachusetts General Hospital 5: Instructors, Department of Medicine at Harvard Medical School and the Institute for Health Policy at Massachusetts General Hospital 6: Prfoessor, Department of Medicine at Harvard Medical School and the Institute for Health Policy at Massachusetts General Hospital; Source Info: Nov/Dec2003, Vol. 22 Issue 6, p156; Subject Term: TEACHING hospitals; Subject Term: MEDICALLY uninsured persons; Subject Term: ACADEMIC medical centers; Subject Term: MEDICAL care; Subject Term: HOSPITALS; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.22.6.156
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Taylor, Michael D.
AU - Xuejun Yin, Michael D.
AU - Stone, Samuel
AU - Moseley, Amy
AU - Ma, Joseph K.-H.
AU - Frazer, David G.
AU - Castranova, Vincent
AU - Ma, Jane Y.C.
T1 - Effect of Asphalt Fume Inhalation Exposure at Simulated Road Paving Conditions Prior to Bacterial Infection on Lung Defense Responses in Rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2003/11//
VL - 15
IS - 13
M3 - Article
SP - 1347
PB - Taylor & Francis Ltd
SN - 08958378
AB - Asphalt fume inhalation has been suspected of affecting immune function in exposed workers. The objective of this study was to evaluate the effect of asphalt exposure on lung immune responses in rats using a bacterial infectivity model. Pathogen-free male Sprague-Dawley rats were exposed by inhalation to asphalt fumes (72.6 ± 4.95 mg/m 3 ) or filtered air for 6 h/day for 5 days. One day after the final asphalt exposure, rats were intratracheally inoculated with 5 × 10 5 Listeria monocytogenes. At 0 (prior to bacterial inoculation), 3, and 7 days after L. monocytogenes instillation, the lungs of each animal were divided. Bronchoalveolar lavage (BAL) was performed on right lungs. The recovered BAL cells were then differentiated and counted, and alveolar macrophage (AM) function was determined. Albumin and lactate dehydrogenase (LDH), two indices of lung injury, were measured in the acellular BAL fluid. To assess bacterial clearance, the left lungs were removed, homogenized, and bacterial colony-forming units (CFUs) were counted. In addition, lung-draining lymph nodes were removed, and lymphocyte phenotype and lymphocyte-induced cytokine production were examined. Asphalt fume exposure did not cause lung injury or inflammation in rats in the absence of infection. Infection induced elevations in AMs, neutrophils (PMNs), albumin, and LDH. Importantly, no significant differences were seen when comparing the asphalt group with the air and nonexposed naive groups at any time before or after infection. Also, asphalt fume inhalation exposure did not affect the rate of pulmonary clearance of L. monocytogenes or AM production of reactive oxygen and nitrogen species. However, asphalt-related increases in lymphocyte secretion of interferon (IFN)-γ, interleukin (IL)-6, and IL-10 were observed at different times after bacterial infection, whereas the total number of lymph-node cells and the percentage of CD4+ and CD8+ cells were not significantly different among the treatment groups. Despite the asphalt-induced changes observed in lymphokine secretion, adaptive immune function seemed to function properly in lung defense against bacterial infection. Because innate nonspecific lung responses and pulmonary clearance of L. monocytogenes were unaffected by asphalt fume exposure, lung defenses were sufficient to control the infection. It was concluded that acute inhalation of asphalt fumes at a high concentration had a minimal effect on lung immune responses to infection in rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPHALT
KW - BITUMINOUS materials
KW - IMMUNE response
KW - LUNGS -- Wounds & injuries
KW - BACTERIAL diseases
N1 - Accession Number: 11160017; Antonini, James M. 1 Roberts, Jenny R. 1 Taylor, Michael D. 1 Xuejun Yin, Michael D. 2 Stone, Samuel 1 Moseley, Amy 2 Ma, Joseph K.-H. 1 Frazer, David G. 1 Castranova, Vincent 1 Ma, Jane Y.C.; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: School of Pharmacy, West Virginia University; Source Info: Nov2003, Vol. 15 Issue 13, p1347; Subject Term: ASPHALT; Subject Term: BITUMINOUS materials; Subject Term: IMMUNE response; Subject Term: LUNGS -- Wounds & injuries; Subject Term: BACTERIAL diseases; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324121 Asphalt Paving Mixture and Block Manufacturing; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Jin J.
AU - Marshall, William D.
AU - Law, Brandon
AU - Lewis, Daniel M.
T1 - Fragmentation patterns of DNA–benzo(a)pyrene diol epoxide adducts characterized by nanoflow LC/quadrupole time-of-flight mass spectrometry
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
Y1 - 2003/11//
VL - 230
IS - 1
M3 - Article
SP - 45
SN - 13873806
AB - Polycyclic aromatic hydrocarbons are a pervasive and abundant class of environmental and workplace pollutants. Formation of covalent DNA adducts has been considered to be a useful dosimeter or molecular biomarker for assessing the exposure to such pollutants. The establishment of prospective models for the formation of DNA adducts may help to understand the mechanisms of the effects. To identify the DNA adducts in this study, the fragmentation patterns of DNA–benzo(a)pyrene diol epoxide adducts were characterized by nanoflow liquid chromatography (LC) coupled to hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometry (Q-TOF-MS). In the experiment, the DNA adducts were synthesized by reaction of calf thymus DNA with anti-benzo(a)pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide(±) (anti-BPDE). The major adducts of N2-deoxyguanosine–benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (N2-dG–BPDE), N6-deoxyadenosine–benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (N6-dA–BPDE), N4-deoxycytidine–benzo(a)pyrene-7,8-epoxide (N4-dC–BPDE), and N3-deoxythymidine–benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide adduct (N3-dT–BPDE) were identified by electrospray positive ionization with TOF-MS/MS scan mode. The results of this study demonstrated that the approach that utilizes collision-induced dissociation leading to a characteristic fragmentation pattern offers a distinct advantage for identification and elucidation of molecular structural features of the DNA adducts. The fragmentation patterns established in this study may be applied to identify DNA adducts in biological systems. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Mass Spectrometry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCYCLIC aromatic hydrocarbons
KW - POLLUTANTS
KW - LIQUID chromatography
KW - DNA adducts
KW - Nanoflow LC/Q-TOF-MS
N1 - Accession Number: 11043684; Wang, Jin J. 1; Email Address: juw9@cdc.gov Marshall, William D. 2 Law, Brandon 1 Lewis, Daniel M. 1; Affiliation: 1: U.S. Department of Health and Human Services, Heath Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Department of Food Science & Agricultural Chemistry, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, Canada H9X 3V9; Source Info: Nov2003, Vol. 230 Issue 1, p45; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: POLLUTANTS; Subject Term: LIQUID chromatography; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Nanoflow LC/Q-TOF-MS; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ijms.2003.08.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brock, William J.
AU - Rodricks, Joseph V.
AU - Rulis, Alan
AU - Dellarco, Vicki L.
AU - Gray, George M.
AU - Lane, Richard W.
T1 - Food Safety: Risk Assessment Methodology and Decision-Making Criteria.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2003/11//Nov/Dec2003
VL - 22
IS - 6
M3 - Article
SP - 435
EP - 451
PB - Taylor & Francis Ltd
SN - 10915818
AB - As our scientific technology grows, risk assessment methods become more complex and, therefore, open to greater scientific debate. Risk assessment has always been a part of the regulatory notification and approval process for foods. However, the methodologies applied to risk assessment and decision-making have become diverse, dependent on a number of features, including the areas of the world in which one operates, the need to use cumulative risk assessment for pesticides and other ingredients or alternative risk assessment considerations for evaluating nontraditional or bioengineered foods. Diverse institutional structures within a single federal regulatory authority may tend to lead to diversity in risk outcomes that creates policy decisions that complicate and confuse the risk management process. On top of this challenge, decisions become more complicated by the need to examine beneficial factors of foods rather than the adverse effects of foods and food additives. Foods are a complex mixture of ingredients. Regulatory groups recognize the need to use new approaches for evaluating the safety and risks associated with foods and food additives, and to do so in a timely manner. The United States Food and Drug Administration (US FDA) in its need to ensure standards of "reasonable certainty of no harm" continues to explore alternative means to be responsive to petitioners as well as continue to examine scientifically validated means, e.g., quantitative structure-activity relationship (QSAR), and computer-assisted programs, within the approval process to assist in the evaluation of risks. Another means to improve the risk management process would include the cumulative risk assessment of pesticides that will, no doubt, be the beginning of more intensive efforts to understand cumulative exposures and the inherent risks from multiple pathways of exposure. The passage of the Food Quality Protection Act (FQPA) resulted in developing additional risk assessment methodologies and approaches to assess the potential for multiple exposures and risks. Addressing the international criteria used in decision-making related to foods safety assessment has resulted in acceptable intake values for food ingredients for carcinogens and noncarcinogens that, in general, tend to be more stringent in the United States compared to Europe. Clearly, the need for harmonization of risk assessment criteria and the impact of the decision process on regulatory approvals and safety assessment is a future need for the continued assurances of food safety. The topics presented in this paper are based on a symposium held in November 2002 at the annual meeting of the American College of Toxicology. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Safety measures
KW - Risk assessment
KW - Food additives
KW - Toxicology -- Congresses
KW - Associations, institutions, etc.
KW - United States
KW - ADI
KW - Food Safety
KW - Pesticides
KW - Risk Assessment
N1 - Accession Number: 11715166; Brock, William J. 1; Email Address: wbrock@environcorp.com; Rodricks, Joseph V. 2; Rulis, Alan 3; Dellarco, Vicki L. 4; Gray, George M. 5; Lane, Richard W.; Affiliations: 1: ENVIRON Health Sciences Institute, Arlington, Virginia, USA; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park Maryland, USA; 3: United States Environmental Protection Agency, Offices of Pesticide program, Washington, DC,USA; 4: Harvard Center for Risk Analysis, School of Public Health, Boston, Massachusetts, USA; 5: Unilever Bestfoods, Englewood Cliffs, New Jersey, USA; Issue Info: Nov/Dec2003, Vol. 22 Issue 6, p435; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Risk assessment; Thesaurus Term: Food additives; Subject Term: Toxicology -- Congresses; Subject Term: Associations, institutions, etc.; Subject: United States; Author-Supplied Keyword: ADI; Author-Supplied Keyword: Food Safety; Author-Supplied Keyword: Pesticides; Author-Supplied Keyword: Risk Assessment; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aaron, Kaytura Felix
AU - Levine, David
AU - Burstin, Helen R.
T1 - ORIGINAL ARTICLES African American Church Participation and Health Care Practices.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2003/11//
VL - 18
IS - 11
M3 - Article
SP - 908
EP - 913
SN - 08848734
AB - While religious involvement is associated with improvements in health, little is known about the relationship between church participation and health care practices. To determine 1) the prevalence of church participation; 2) whether church participation influences positive health care practices; and 3) whether gender, age, insurance status, and levels of comorbidity modified these relationships. A cross-sectional analysis using survey data from 2196 residents of a low-income, African-American neighborhood. Our independent variable measured the frequency of church attendance. Dependent variables were: 1) Pap smear; 2) mammogram; and 3) dental visit—all taking place within 2 years; 4) blood pressure measurement within 1 year, 5) having a regular source of care, and 6) no perceived delays in care in the previous year. We controlled for socioeconomic factors and the number of comorbid conditions and also tested for interactions. Thirty-seven percent of community members went to church at least monthly. Church attendance was associated with increased likelihood of positive health care practices by 20% to 80%. In multivariate analyses, church attendance was related to dental visits (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.3 to 1.9) and blood pressure measurements (OR, 1.6; 95% CI, 1.2 to 2.1). Insurance status and number of comorbid conditions modified the relationship between church attendance and Pap smear, with increased practices noted for the uninsured (OR, 2.3; 95% CI, 1.2 to 4.1) and for women with 2 or more comorbid conditions (OR, 1.9; 95% CI, 1.1 to 3.5). Church attendance is an important correlate of positive health care practices, especially for the most vulnerable subgroups, the uninsured and chronically ill. Community- and faith-based organizations present additional opportunities to improve the health of low-income and minority populations. J GEN INTERN MED 2003; 18:908–913. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHURCH attendance
KW - MEDICAL care
KW - PHYSICIAN practice patterns
KW - RELIGIOUSNESS
KW - church attendance
KW - health care practices
KW - health care services
KW - preventive services
KW - religiosity.
N1 - Accession Number: 11414787; Aaron, Kaytura Felix 1; Email Address: kfaaron@ahrq.gov Levine, David 2,3 Burstin, Helen R. 1; Affiliation: 1: Center of Primary Care Research, Agency of Healthcare Research and Quality, Rockville. 2: Departments of Medicine and Health Policy, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Md (DL). 3: Departments of Management, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Md (DL).; Source Info: Nov2003, Vol. 18 Issue 11, p908; Subject Term: CHURCH attendance; Subject Term: MEDICAL care; Subject Term: PHYSICIAN practice patterns; Subject Term: RELIGIOUSNESS; Author-Supplied Keyword: church attendance; Author-Supplied Keyword: health care practices; Author-Supplied Keyword: health care services; Author-Supplied Keyword: preventive services; Author-Supplied Keyword: religiosity.; Number of Pages: 6p; Document Type: Article
L3 - 10.1046/j.1525-1497.2003.20936.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - D. G. White
AU - A. Datta
AU - P. McDermott
AU - S. Friedman
AU - S. Qaiyumi
AU - S. Ayers
AU - L. English
AU - S. McDermott
AU - D. D. Wagner
AU - S. Zhao
T1 - Antimicrobial susceptibility and genetic relatedness of Salmonella serovars isolated from animal-derived dog treats in the USA.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2003/11//
VL - 52
IS - 5
M3 - Article
SP - 860
EP - 863
SN - 03057453
N1 - Accession Number: 11493946; D. G. White 1; A. Datta 2; P. McDermott 1; S. Friedman 1; S. Qaiyumi; S. Ayers 1; L. English 1; S. McDermott 1; D. D. Wagner 1; S. Zhao 1; Affiliations: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine; 2: Division of Field Science, Office of Regulatory Affairs, US Food and Drug Administration, Rockville, MD 20708, USA; Issue Info: Nov2003, Vol. 52 Issue 5, p860; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Asafu-Adjaye, Ebenezer B.
AU - Siu Kay Wong, Ebenezer B.
T1 - Determination of Ginsenosides (Ginseng Saponins) in Dry Root Powder from Panax ginseng, Panax quinquefolius, and Selected Commercial Products by Liquid Chromatography: Interlaboratory Study.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/11//Nov/Dec2003
VL - 86
IS - 6
M3 - Article
SP - 1112
EP - 1123
SN - 10603271
AB - Determines Ginsenosides in Dry Root Powder from Panax ginseng, Panax quinqufolius, and selected commercial products by liquid chromatography. Increase of the use and economic importance of ginseng products; Costs of the ginsenoside reference standards; Analysis of the methanol extract using ultraviolet detection.
KW - GINSENG
KW - ULTRAVIOLET radiation
KW - COMMERCIAL products
KW - LIQUID chromatography
KW - METHANOL
N1 - Accession Number: 12372576; Asafu-Adjaye, Ebenezer B. 1; Email Address: asafue@cder.fda.gov Siu Kay Wong, Ebenezer B. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Product Quality Research Laboratory, HFD-941, NLRC Ste 2400, Rockville, Maryland 20857 2: Hong Kong Government Laboratory, Homanti Government Offices, 88 Chung Hau St, Hong Kong; Source Info: Nov/Dec2003, Vol. 86 Issue 6, p1112; Subject Term: GINSENG; Subject Term: ULTRAVIOLET radiation; Subject Term: COMMERCIAL products; Subject Term: LIQUID chromatography; Subject Term: METHANOL; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cieri, Ugo R.
T1 - Determination of Atropine (Hyoscyamine) Sulfate in Commercial Products by Liquid Chromatography with UV Absorbance and Fluorescence Detection: Multilaboratory Study.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/11//Nov/Dec2003
VL - 86
IS - 6
M3 - Article
SP - 1128
EP - 1134
SN - 10603271
AB - Determines the atropine sulfate in commercial products by liquid chromatography with ultraviolet absorbance and fluorescence detection. Accounts on the therapeutic properties of belladonna alkaloids; Approximation of the equal amounts of the L and D isomers; Causes of degredation of the active ingredients.
KW - ATROPINE
KW - COMMERCIAL products
KW - LIQUID chromatography
KW - ULTRAVIOLET radiation
KW - BELLADONNA (Drug)
KW - ALKALOIDS
KW - FLUORESCENCE
KW - SULFATES
N1 - Accession Number: 12372578; Cieri, Ugo R. 1; Email Address: ucieri@ora.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 2nd and Chestnut Sts, Philadelphia, Pennsylvania 19106; Source Info: Nov/Dec2003, Vol. 86 Issue 6, p1128; Subject Term: ATROPINE; Subject Term: COMMERCIAL products; Subject Term: LIQUID chromatography; Subject Term: ULTRAVIOLET radiation; Subject Term: BELLADONNA (Drug); Subject Term: ALKALOIDS; Subject Term: FLUORESCENCE; Subject Term: SULFATES; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hammack, Walter
AU - Carson, Mary C.
AU - Neuhaus, Barbara K.
AU - Hurlbut, Jeffrey A.
AU - Nochetto, Cristina
AU - Stuart, James S.
AU - Brown, Amy
AU - Kilpatrick, Donna
AU - Youngs, Kristl
AU - Ferbos, Krystle
AU - Heller, David N.
T1 - Multilaboratory Validation of a Method To Confirm Chloramphenicol in Shrimp and Crabmeat by Liquid Chromatography-Tandem Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/11//Nov/Dec2003
VL - 86
IS - 6
M3 - Article
SP - 1135
EP - 1143
SN - 10603271
AB - Describest the multilaboratory validation of a method to confirm chloramphenicol in shrimp and crabmeat by liquid chromatography-tandem mass spectrometry in the U.S. Decrease of red blood cell production in bone marrow leading to aplastic anemia; Adequacy of selectivity to confirm residue presence; Differences in shrimp extract preparation.
KW - SHRIMPS
KW - CRAB meat
KW - LIQUID chromatography
KW - APLASTIC anemia
KW - ERYTHROCYTES
KW - MASS spectrometry
KW - UNITED States
N1 - Accession Number: 12372579; Hammack, Walter 1 Carson, Mary C. 2; Email Address: mcarson@cvm.fda.gov Neuhaus, Barbara K. 3 Hurlbut, Jeffrey A. 2 Nochetto, Cristina 3 Stuart, James S. 1 Brown, Amy 2 Kilpatrick, Donna Youngs, Kristl Ferbos, Krystle Heller, David N.; Affiliation: 1: Florida Department of Agriculture and Consumer Services, Chemical Residue Laboratory, 3125 Conner Blvd, Tallahassee, Florida 32399 2: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd, Laurel, Maryland 20708 3: U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, Washington 98021; Source Info: Nov/Dec2003, Vol. 86 Issue 6, p1135; Subject Term: SHRIMPS; Subject Term: CRAB meat; Subject Term: LIQUID chromatography; Subject Term: APLASTIC anemia; Subject Term: ERYTHROCYTES; Subject Term: MASS spectrometry; Subject Term: UNITED States; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rogers, Patricia L.
AU - Staruszkiewicz, Walter F.
AU - Benner Jr., Ronald A.
T1 - Gas Chromatographic Method for Putrescine and Cadaverine in Shrimp.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/11//Nov/Dec2003
VL - 86
IS - 6
M3 - Article
SP - 1172
EP - 1178
SN - 10603271
AB - Reports on the development of a gas-liquid chromatographic method for the determination of putrescine and cadaverine in shrimp in the U.S. Increase of the recovery of putrescine; Improvement of the derivatized diamines; Lack of adequate refrigeration in the geographical regions; Minimization of the gel formation.
KW - GAS chromatography
KW - PUTRESCINE
KW - SHRIMPS
KW - REFRIGERATION & refrigerating machinery
KW - AMINES
KW - COLLOIDS
KW - UNITED States
N1 - Accession Number: 12372584; Rogers, Patricia L. 1; Email Address: PRogers@cfsan.fda.gov Staruszkiewicz, Walter F. 1 Benner Jr., Ronald A. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington Seafood Laboratory, HFS-426, Beltsville Research Facility, 8301 Muirkirk Rd, Laurel, Maryland 20708; Source Info: Nov/Dec2003, Vol. 86 Issue 6, p1172; Subject Term: GAS chromatography; Subject Term: PUTRESCINE; Subject Term: SHRIMPS; Subject Term: REFRIGERATION & refrigerating machinery; Subject Term: AMINES; Subject Term: COLLOIDS; Subject Term: UNITED States; NAICS/Industry Codes: 333416 Heating equipment and commercial refrigeration equipment manufacturing; NAICS/Industry Codes: 333415 Air-Conditioning and Warm Air Heating Equipment and Commercial and Industrial Refrigeration Equipment Manufacturing; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 423740 Refrigeration Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tortorello, Mary L.
T1 - Indicator Organisms for Safety and Quality—Uses and Methods for Detection: Minireview.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2003/11//Nov/Dec2003
VL - 86
IS - 6
M3 - Article
SP - 1208
EP - 1217
SN - 10603271
AB - Describes the use of the indicator organisms to assess the microbiological status of water and foods in the U.S. Prevention of milkborne disease; Cause of the multistate outbreak of typhoid; Avoidance of fecal contamination of water supplies.
KW - PATHOGENIC microorganisms
KW - WATER supply
KW - TYPHOID fever
KW - FOOD contamination
KW - UNITED States
N1 - Accession Number: 12372589; Tortorello, Mary L. 1; Email Address: mlt@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Rd, Summit-Argo, Illinois 60501; Source Info: Nov/Dec2003, Vol. 86 Issue 6, p1208; Subject Term: PATHOGENIC microorganisms; Subject Term: WATER supply; Subject Term: TYPHOID fever; Subject Term: FOOD contamination; Subject Term: UNITED States; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Qian H.
AU - Huque, Mohammad F.
T1 - A Decision Rule for Evaluating Several Independent Clinical Trials Collectively#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2003/11//
VL - 13
IS - 4
M3 - Article
SP - 621
PB - Taylor & Francis Ltd
SN - 10543406
AB - Usually, in applying for market approval of a new drug, more than one similarly designed clinical trial is conducted to support efficacy claims. How to evaluate these trials collectively and assess the overall type I error of a decision rule can be a challenging statistical issue. In this paper, we propose a decision rule to collectively evaluate p-values from several similarly designed and independently conducted trials. A concept of overall hypotheses, which is essentially union or intersection combinations of individual trials’ hypotheses, is used so that the overall type I error can be controlled at desired levels. We also discuss some important properties of the approach, including the selection of the overall type I error rates and power. Examples are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Effectiveness
KW - DECISION making
KW - EVALUATION
KW - CLINICAL trials
KW - Clinical trials
KW - Decision rules
KW - Multiplicity
KW - Overall hypotheses
KW - Overall type I error
KW - p-Value cut points.
N1 - Accession Number: 11093011; Li, Qian H. 1; Email Address: liq@cder.fda.gov Huque, Mohammad F. 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, HFD-725, Rockville, Maryland, USA.; Source Info: Nov2003, Vol. 13 Issue 4, p621; Subject Term: DRUGS -- Effectiveness; Subject Term: DECISION making; Subject Term: EVALUATION; Subject Term: CLINICAL trials; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Decision rules; Author-Supplied Keyword: Multiplicity; Author-Supplied Keyword: Overall hypotheses; Author-Supplied Keyword: Overall type I error; Author-Supplied Keyword: p-Value cut points.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1081/BIP-120024198
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tie-Hua Ng, Ludwig A.
T1 - Issues of Simultaneous Tests for Noninferiority and Superiority#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2003/11//
VL - 13
IS - 4
M3 - Article
SP - 629
PB - Taylor & Francis Ltd
SN - 10543406
AB - In simultaneous testing for noninferiority and superiority, Morikawa and Yoshida (Morikawa, T., Yoshida, M. (1995). A useful testing strategy in phase III trails: Combined test of superiority and test of equivalence. J. Biopharmaceutical Statistics 5:297–306) argue that multiplicity adjustment is not necessary by using the closed testing (CT) principle. In fact, using the same argument, no multiplicity adjustment is necessary in simultaneous testing of any number of nested null hypotheses. However, simultaneous testing of many nested null hypotheses is problematic in a confirmatory trial because such simultaneous testing is similar to post-hoc specification of the null hypothesis. Thus, simultaneous testing for noninferiority and superiority may be viewed as an initial step towards exploratory analysis and may be best used cautiously in confirmatory evaluation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIPLICITY (Mathematics)
KW - HYPOTHESIS
KW - CLINICAL trials
KW - Active control
KW - Equivalence testing
KW - Exploratory and confirmatory analysis.
KW - Multiplicity adjustment
N1 - Accession Number: 11093010; Tie-Hua Ng, Ludwig A. 1; Email Address: ng@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA.; Source Info: Nov2003, Vol. 13 Issue 4, p629; Subject Term: MULTIPLICITY (Mathematics); Subject Term: HYPOTHESIS; Subject Term: CLINICAL trials; Author-Supplied Keyword: Active control; Author-Supplied Keyword: Equivalence testing; Author-Supplied Keyword: Exploratory and confirmatory analysis.; Author-Supplied Keyword: Multiplicity adjustment; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Document Type: Article
L3 - 10.1081/BIP-120024199
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huey-miin Hsueh, Peter H.
AU - Chen, James J.
AU - Kodell, Ralph L.
T1 - Comparison of Methods for Estimating the Number of True Null Hypotheses in Multiplicity Testing.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2003/11//
VL - 13
IS - 4
M3 - Article
SP - 675
PB - Taylor & Francis Ltd
SN - 10543406
AB - When a large number of statistical tests is performed, the chance of false positive findings could increase considerably. The traditional approach is to control the probability of rejecting at least one true null hypothesis, the familywise error rate (FWE). To improve the power of detecting treatment differences, an alternative approach is to control the expected proportion of errors among the rejected hypotheses, the false discovery rate (FDR). When some of the hypotheses are not true, the error rate from either the FWE- or the FDR-controlling procedure is usually lower than the designed level. This paper compares five methods used to estimate the number of true null hypotheses over a large number of hypotheses. The estimated number of true null hypotheses is then used to improve the power of FWE- or FDR-controlling methods. Monte Carlo simulations are conducted to evaluate the performance of these methods. The lowest slope method, developed by Benjamini and Hochberg (2000) on the adaptive control of the FDR in multiple testing with independent statistics, and the mean of differences method appear to perform the best. These two methods control the FWE properly when the number of nontrue null hypotheses is small. A data set from a toxicogenomic microarray experiment is used for illustration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - MONTE Carlo method
KW - SIMULATION methods & models
KW - CLINICAL trials
KW - Comparisonwise error rate (CWE)
KW - False discovery rate (FDR)
KW - Familywise error rate (FWE)
KW - Multiple endpoints
KW - Number of true number hypotheses.
N1 - Accession Number: 11093008; Huey-miin Hsueh, Peter H. 1; Email Address: hsueh@nccu.edu.tw Chen, James J. 2 Kodell, Ralph L. 2; Affiliation: 1: Department of Statistics, National Chengchi University, Taipei, Taiwan. 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.; Source Info: Nov2003, Vol. 13 Issue 4, p675; Subject Term: ESTIMATION theory; Subject Term: MONTE Carlo method; Subject Term: SIMULATION methods & models; Subject Term: CLINICAL trials; Author-Supplied Keyword: Comparisonwise error rate (CWE); Author-Supplied Keyword: False discovery rate (FDR); Author-Supplied Keyword: Familywise error rate (FWE); Author-Supplied Keyword: Multiple endpoints; Author-Supplied Keyword: Number of true number hypotheses.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Document Type: Article
L3 - 10.1081/BIP-120024202
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bauer, Peter
AU - Chi, George
AU - Geller, Nancy
AU - Gould, A. Lawrence
AU - Jordan, David
AU - Mohanty, Surya
AU - O'neill, Robert
AU - Westfall, Peter H.
T1 - Industry, Government, and Academic Panel Discussion on Multiple Comparisons in a “Real” Phase Three Clinical Trial.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2003/11//
VL - 13
IS - 4
M3 - Article
SP - 691
PB - Taylor & Francis Ltd
SN - 10543406
AB - A Food and Drug Administration (FDA)/Industry/Academic Panel Discussion on multiplicity aspects of a real Phase III clinical trial was held at the Third International Conference on Multiple Comparisons, August 6, 2002, in Bethesda, Maryland. The goal was to develop some consensus among industry, government, and academic statisticians concerning requirements and methods for multiplicity management in typical clinical trials. The session was tape-recorded; this article mostly comes from an edited transcript. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FORUMS (Discussion & debate)
KW - INDUSTRIAL management
KW - CLINICAL trials
KW - BETHESDA (Md.)
KW - MARYLAND
KW - UNITED States
KW - Closed testing proceDure
KW - Efficacy
KW - Multiple endpoints
KW - Multiple treatment arms
KW - Noninferiority testing
KW - Protocol
KW - Safety.
KW - Superiority testing
N1 - Accession Number: 11093007; Bauer, Peter 1; Email Address: peter.bauer@univie.ac.at Chi, George 2 Geller, Nancy 3 Gould, A. Lawrence 4 Jordan, David 5 Mohanty, Surya 6 O'neill, Robert 2 Westfall, Peter H. 7; Affiliation: 1: University of Vienna, Vienna, Austria. 2: U.S. Food and Drug Administration, Bethesda, Maryland, USA. 3: National Heart, Lung and Blood Institute, Bethesda, Maryland, USA. 4: Merck Research Laboratories, West Point, Pennsylvania, USA. 5: Pharmacia/Upjohn, Skokie, Illinois, USA. 6: Johnson & Johnson Pharmaceutical Research and Development, Titusville, New Jersey, USA. 7: Texas Tech University, Lubbock, Texas, USA.; Source Info: Nov2003, Vol. 13 Issue 4, p691; Subject Term: FORUMS (Discussion & debate); Subject Term: INDUSTRIAL management; Subject Term: CLINICAL trials; Subject Term: BETHESDA (Md.); Subject Term: MARYLAND; Subject Term: UNITED States; Author-Supplied Keyword: Closed testing proceDure; Author-Supplied Keyword: Efficacy; Author-Supplied Keyword: Multiple endpoints; Author-Supplied Keyword: Multiple treatment arms; Author-Supplied Keyword: Noninferiority testing; Author-Supplied Keyword: Protocol; Author-Supplied Keyword: Safety.; Author-Supplied Keyword: Superiority testing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Document Type: Article
L3 - 10.1081/BIP-120024203
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fu, P. P.
AU - Cheng, S.-H.
AU - Coop, L.
AU - Xia, Q.
AU - Culp, S. J.
AU - Totteson, W. H.
AU - Wamer, W. G.
AU - Howard, P. C.
T1 - Photoreaction, Phototoxicity, and Photocarcinogenicity of Retinoids.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2003/11//
VL - 21
IS - 2
M3 - Article
SP - 165
EP - 197
SN - 10590501
AB - Sunlight is a human carcinogen. Many retinoid-containing cosmetics are used to protect damages caused by sunlight irradiation. Since retinol is thermally unstable and retinyl palmitate (RP) is relatively more stable, RP is also widely used as an ingredient in cosmetic formulations, in general, little is known about the photodecomposition of retinoids and the toxicity of retinoids and their photodecomposition products on the skin's responses to sunlight. This review focuses on the update information on photoreactions, phototoxicity, and photocarcinogenicity of the natural retinoids including retinol, retinal, retinoid acid (RA), retinyl acetate, and RP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sunshine
KW - Carcinogens
KW - Retinoids
KW - Cosmetics
KW - Photometry
KW - Photocarcinogenicity.
KW - Phototoxicity
KW - Retinoid acid
KW - Retinol
KW - Retinyl palmitate
KW - Vitamin A
N1 - Accession Number: 11398197; Fu, P. P. 1,2; Email Address: pfu@nctr.fda.gov.; Cheng, S.-H. 1; Coop, L. 2; Xia, Q. 1; Culp, S. J. 1; Totteson, W. H. 1; Wamer, W. G. 3; Howard, P. C. 1,2; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.; 2: Department of Pharmacology and Toxicology, The College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; 3: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA.; Issue Info: Nov2003, Vol. 21 Issue 2, p165; Thesaurus Term: Sunshine; Thesaurus Term: Carcinogens; Subject Term: Retinoids; Subject Term: Cosmetics; Subject Term: Photometry; Author-Supplied Keyword: Photocarcinogenicity.; Author-Supplied Keyword: Phototoxicity; Author-Supplied Keyword: Retinoid acid; Author-Supplied Keyword: Retinol; Author-Supplied Keyword: Retinyl palmitate; Author-Supplied Keyword: Vitamin A; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 33p; Document Type: Article
L3 - 10.1081/GNC-120026235
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Petronis, K. R.
AU - Anthony, J. C.
T1 - A Different kind of contextual effect: geographical clustering of cocaine incidence in the USA.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2003/11//
VL - 57
IS - 11
M3 - Article
SP - 893
EP - 900
SN - 0143005X
AB - Study objective: Outline the use of the pairwise odds ratio (PWOR) to quantify the extent to which a binary outcome clusters geographically. Quantify the extent to which first experience with cocaine is spatially correlated within US neighbourhoods and cities. Quantify geographical clustering of first experience with cocaine by neighbourhood context. Design: Estimate the PWOR of incident cocaine experience at two levels (neighbourhood, city) and compare across years. Within years, estimate the PWOR by neighbourhood disadvantage and test for trend. Setting: US National Household Survey on Drug Abuse. Participants: Civilian, non-institutionalised household residents of the United States age 1 2 years and older interviewed in person during 1979, 1988, 1990, 1991, 1992, 1993. Main results: First experience with cocaine clusters within US neighbourhoods and cities. There is some evidence that the spatial correlation of first experience with cocaine increases with percentage of neighbourhood households living in poverty. Conclusions: The gradient in spatial correlation of incident cocaine experience by neighbourhood poverty level is consistent with current theories of concentrated disadvantage. The possibility that the direction of the poverty gradient might change over the course of a drug epidemic is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Epidemiology & Community Health is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCAINE
KW - NEIGHBORHOODS
KW - CITIES & towns
KW - POOR people
KW - POVERTY
KW - UNITED States
N1 - Accession Number: 12885547; Petronis, K. R. 1,2; Email Address: kpetroni@somhsa.gov Anthony, J. C. 2; Affiliation: 1: Substance Abuse and Mental Health Services Administration, Office of Applied Studies, Rockville, Maryland, USA. 2: Johns Hopkins University, Bloomberg School of Public Health, Department of Mental Hygiene, Baltimore Maryland, USA.; Source Info: Nov2003, Vol. 57 Issue 11, p893; Subject Term: COCAINE; Subject Term: NEIGHBORHOODS; Subject Term: CITIES & towns; Subject Term: POOR people; Subject Term: POVERTY; Subject Term: UNITED States; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106744529
T1 - A different kind of contextual effect: geographical clustering of cocaine incidence in the USA.
AU - Petronis KR
AU - Anthony JC
Y1 - 2003/11//
N1 - Accession Number: 106744529. Language: English. Entry Date: 20040611. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 7909766.
KW - Cocaine
KW - Geographic Factors
KW - Substance Abuse -- Risk Factors -- United States
KW - Cluster Sample
KW - Confidence Intervals
KW - Incidence
KW - Interviews
KW - Logistic Regression
KW - Odds Ratio
KW - Random Sample
KW - Socioeconomic Factors
KW - Surveys
KW - United States
KW - Human
SP - 893
EP - 900
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
JA - J EPIDEMIOL COMMUNITY HEALTH
VL - 57
IS - 11
PB - BMJ Publishing Group
AB - STUDY OBJECTIVE: Outline the use of the pairwise odds ratio (PWOR) to quantify the extent to which a binary outcome clusters geographically. Quantify the extent to which first experience with cocaine is spatially correlated within US neighbourhoods and cities. Quantify geographical clustering of first experience with cocaine by neighbourhood context. DESIGN: Estimate the PWOR of incident cocaine experience at two levels (neighbourhood, city) and compare across years. Within years, estimate the PWOR by neighbourhood disadvantage and test for trend. SETTING: US National Household Survey on Drug Abuse. PARTICIPANTS: Civilian, non-institutionalised household residents of the United States age 12 years and older interviewed in person during 1979, 1988, 1990, 1991, 1992, 1993. Main results: First experience with cocaine clusters within US neighbourhoods and cities. There is some evidence that the spatial correlation of first experience with cocaine increases with percentage of neighbourhood households living in poverty. CONCLUSIONS: The gradient in spatial correlation of incident cocaine experience by neighbourhood poverty level is consistent with current theories of concentrated disadvantage. The possibility that the direction of the poverty gradient might change over the course of a drug epidemic is discussed.
SN - 0143-005X
AD - Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 5600 Fishers Lane, 16-105, Rockville, MD 20857; kpetroni@samhsa.gov
U2 - PMID: 14600117.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Su-Sen Chang, Mansel W.
AU - Gray, Peter M.
AU - Gun-Jo Woo, Peter M.
AU - Dong-Hyun Kang
T1 - A New Alginate-Based Rapid Method for Determining Coliforms in Milk.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/11//
VL - 66
IS - 11
M3 - Article
SP - 2146
EP - 2150
SN - 0362028X
AB - A new rapid method for monitoring coliforms was developed on the basis of the instant gelling effects of alginate and calcium. The effectiveness of this new method in the detection of coliforms was evaluated. Tests involving Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, total coliforms in milk, cold-injured coliforms, and total coliforms in raw milk were carried out. The bacterial samples were diluted in 0.2% peptone water containing 90 mM CaCl[sub 2] and added into test tubes containing modified purple broth base medium. Coliform concentrations were determined on the basis of the time of color change and gas production in the alginate tubes. All results obtained by the alginate method correlated strongly with those obtained by the conventional violet red bile agar (VRBA) plating method. The alginate method reduced detection time by 12 to 14 h compared with the conventional VRBA plating method. The alginate method can be applied in field studies more easily than melted-agar systems can. The results of this study indicate that the alginate method is an accurate, rapid, simple, and economical way to monitor and estimate concentrations of total coliforms in food. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Milk
KW - Microbial contamination
KW - Bacteria
KW - Calcium
KW - Alginates
KW - Cultures (Biology)
N1 - Accession Number: 11683107; Su-Sen Chang, Mansel W. 1; Gray, Peter M. 1; Gun-Jo Woo, Peter M. 2; Dong-Hyun Kang 1; Email Address: dhkang@wsu.edu; Affiliations: 1: Department of Food Science and Human Nutrition, Washington State University; 2: Food Microbiology Division, Korea Food and Drug Administration; Issue Info: Nov2003, Vol. 66 Issue 11, p2146; Thesaurus Term: Milk; Thesaurus Term: Microbial contamination; Thesaurus Term: Bacteria; Thesaurus Term: Calcium; Subject Term: Alginates; Subject Term: Cultures (Biology); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; Number of Pages: 5p; Illustrations: 2 Black and White Photographs, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106775857
T1 - Maternal drug use and the timing of prenatal care.
AU - Brady TM
AU - Visscher W
AU - Feder M
AU - Burns AM
Y1 - 2003/11//
N1 - Accession Number: 106775857. Language: English. Entry Date: 20040910. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Grant Information: Supported in part by contract 283-99-9018 from the Office of Applied Studies at the Substance Abuse and Mental Health Services Administration and contract 271-89-8340 from the Division of Epidemiology and Prevention Research at the National Institute on Drug Abuse. NLM UID: 9103800.
KW - Prenatal Care
KW - Substance Abuse, Perinatal
KW - Time Factors
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Attitude to Pregnancy
KW - Bivariate Statistics
KW - Chi Square Test
KW - Cocaine
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - District of Columbia
KW - Female
KW - Goodness of Fit Chi Square Test
KW - Health Services Accessibility
KW - Interviews
KW - Logistic Regression
KW - Multivariate Statistics
KW - Odds Ratio
KW - Pregnancy
KW - Pregnancy Outcomes
KW - Pregnancy Trimester, Third
KW - Random Sample
KW - Risk Factors
KW - Surveys
KW - Treatment Delay
KW - Univariate Statistics
KW - Funding Source
KW - Human
SP - 588
EP - 607
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 14
IS - 4
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - This paper explores the role of maternal drug use and the timing of prenatal care. The study data were collected from women delivering live births at eight participating hospitals in the Washington, D.C., Metropolitan Area Drug Study. An estimated 16.9 percent of the women in this sample initiated prenatal care in their third trimester or received no prenatal care. After adjusting for age, race/ethnicity, education, parity, and attitude toward pregnancy, cocaine use was strongly associated with the timing of prenatal care. Using multivariable ordinal logistic regression, the data suggest significant barriers to prenatal care for substance abusers, especially cocaine users. Increasing access to prenatal care continues to be an important public health policy objective, particularly in urban areas where substance abuse is prevalent. Health services research must test strategies that address the timing of prenatal care among drug-dependent, urban women.
SN - 1049-2089
AD - Service Fellow, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD
U2 - PMID: 14619557.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106775857&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106711201
T1 - Inappropriate emergency department visits and use of the Health Care for the Homeless Program services by homeless adults in the northeastern United States.
AU - Han B
AU - Wells BL
Y1 - 2003/11//Nov/Dec2003
N1 - Accession Number: 106711201. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Grant Information: One Percent Set-Aside Evaluation Funds, Health Resources and Services Administration, U.S. Department of Health and Human Services. NLM UID: 9505213.
KW - Community Health Services -- Utilization -- New England
KW - Emergency Service -- Utilization
KW - Health Resource Utilization
KW - Health Services Accessibility
KW - Homelessness
KW - Adult
KW - Confidence Intervals
KW - Connecticut
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Food Services
KW - Funding Source
KW - Homeless Persons
KW - Insurance, Health
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Medically Underserved
KW - Middle Age
KW - New England
KW - New Jersey
KW - Odds Ratio
KW - P-Value
KW - Pennsylvania
KW - Random Sample
KW - Record Review
KW - Rhode Island
KW - Human
SP - 530
EP - 537
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 9
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - Bureau of Primary Health Care, 4350 East-West Highway, 9-3A1, Bethesda, MD 20814; bhan@hrsa.gov
U2 - PMID: 14606193.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106711201&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Prabhakar, Ganga
AU - Vona-Davis, Linda
AU - Murray, David
AU - Lakhani, Paresh
AU - Murray, Gordon
T1 - Phosphocreatine restores high-energy phosphates in ischemic myocardium: implication for off-pump cardiac revascularization
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
Y1 - 2003/11//
VL - 197
IS - 5
M3 - Article
SP - 786
SN - 10727515
AB - : BackgroundHigh-energy phosphate metabolism is altered in the ischemic myocardium. We investigated the effects of in vivo administration of phosphocreatine (PCr) in a transient ischemic rat model to emulate off-pump myocardial revascularization.: Study designRats received either PCr (100 mg/kg) or saline intravenously 1 hour before surgery. Regional ischemia was maintained for 12 minutes by ligation of the left anterior descending artery and compared with sham-operated animals. Cardiac tissue was studied for ATP, PCr, and inorganic phosphate (Pi) using 31P-cryo-NMR. Results were compared by ANOVA.: ResultsLevels of ATP were significantly (p < 0.01) lower in the ischemic hearts compared with controls; Pi and PCr remained unchanged. The PCr/Pi ratio was altered in ischemic hearts, reflecting an increased energy demand. PCr administration significantly (p < 0.01) elevated the content of PCr and ATP in both normal and ischemic hearts.: ConclusionsPCr restores high-energy phosphates and attenuates metabolic stress during periods of myocardial ischemia in the rat. Preconditioning with PCr may serve as a useful adjunct to off-pump coronary revascularization. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Surgeons is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISCHEMIA
KW - MYOCARDIUM
KW - MYOCARDIAL revascularization
KW - THERAPEUTICS
KW - inorganic phosphate
KW - NMR
KW - nuclear magnetic resonance
KW - PCr
KW - phosphocreatine
KW - Pi
N1 - Accession Number: 11175774; Prabhakar, Ganga 1 Vona-Davis, Linda 1 Murray, David 2 Lakhani, Paresh 1 Murray, Gordon 1; Affiliation: 1: West Virginia University, Department of Surgery, Morgantown, WV USA 2: National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA; Source Info: Nov2003, Vol. 197 Issue 5, p786; Subject Term: ISCHEMIA; Subject Term: MYOCARDIUM; Subject Term: MYOCARDIAL revascularization; Subject Term: THERAPEUTICS; Author-Supplied Keyword: inorganic phosphate; Author-Supplied Keyword: NMR; Author-Supplied Keyword: nuclear magnetic resonance; Author-Supplied Keyword: PCr; Author-Supplied Keyword: phosphocreatine; Author-Supplied Keyword: Pi; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jamcollsurg.2003.05.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11175774&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dilley, A.
AU - Hooper, W.C.
AU - Austin, H.
AU - Jamil, M.
AU - Miller, C.
AU - Stokes, M.
AU - Evatt, B.
AU - Eldridge, J.
T1 - ORIGINAL ARTICLE The β fibrinogen gene G-455-A polymorphism is a risk factor for Legg–Perthes disease.
JO - Journal of Thrombosis & Haemostasis
JF - Journal of Thrombosis & Haemostasis
Y1 - 2003/11//
VL - 1
IS - 11
M3 - Article
SP - 2317
EP - 2321
PB - Wiley-Blackwell
SN - 15387933
AB - Legg–Perthes disease is a pediatric hip disorder characterized by avascular necrosis of the femoral head. The etiology of Legg–Perthes disease may involve repeated interruptions of the blood supply to the proximal femur. Thus, the role of thrombosis in Legg–Perthes disease is of interest. The focus of this analysis is an evaluation of the relationship between Legg–Perthes disease and the β fibrinogen gene G-455-A polymorphism in 55 cases of Legg–Perthes disease and 56 age, race, and gender-matched healthy controls. Parents of subjects completed a questionnaire about their child's lifestyle and medical history. Blood was obtained for plasma and DNA analysis. Study subjects were predominantly white (93%), male (77%) and under age 16 (70%). Cases were more likely to be exposed to passive smoke than were controls (odds ratio 5.6, 95% confidence interval 2.0–12.0). Assuming a dominant genetic model, individuals who possessed either the G/A or A/A genotype were over three times more likely to have Legg–Perthes disease compared to those without the polymorphism (odds ratio 3.4, 95% confidence interval 1.5–7.8). Separate analyzes by smoke exposure revealed that the excess risk of the G-455-A polymorphism occurred in those exposed (odds ratio 7.0) as opposed to those unexposed to passive smoke (odds ratio 1.9). Although this difference in the odds ratios is not statistically significant ( P = 0.2), it suggests a possible interactive effect of cigarette smoke and the b fibrinogen gene G-455-A polymorphism in the risk of developing Legg–Perthes disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Thrombosis & Haemostasis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIP joint -- Diseases
KW - NECROSIS
KW - THROMBOSIS
KW - LEGG-Calve-Perthes disease
KW - coagulation
KW - fibrinogen
KW - legg–perthes disease
N1 - Accession Number: 11351342; Dilley, A. 1; Email Address: adiley@cdc.gov Hooper, W.C. 1 Austin, H. 1,2 Jamil, M. 1,2 Miller, C. 1 Stokes, M. 2 Evatt, B. 1 Eldridge, J. 3; Affiliation: 1: Hematologic Diseases Branch, Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services 2: Department of Epidemiology, Rollins School of Public Health of Emory University, Atlanta, Georgia 3: University of Louisville School of Medicine, Department of Orthopedics and Pediatrics, Louisville, Kentucky, USA; Source Info: Nov2003, Vol. 1 Issue 11, p2317; Subject Term: HIP joint -- Diseases; Subject Term: NECROSIS; Subject Term: THROMBOSIS; Subject Term: LEGG-Calve-Perthes disease; Author-Supplied Keyword: coagulation; Author-Supplied Keyword: fibrinogen; Author-Supplied Keyword: legg–perthes disease; Number of Pages: 5p; Document Type: Article
L3 - 10.1046/j.1538-7836.2003.00416.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Claire Y.-H. Huang, Paul M.
AU - Butrapet, Siritorn
AU - Tsuchiya, Kiyotaka R.
AU - Bhamarapravati, Natth
AU - Gublier, Duane J.
AU - Kinney, Richard M.
T1 - Dengue 2 PDK-53 Virus as a Chimeric Carrier for Tetravalent Dengue Vaccine Development.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003/11//
VL - 77
IS - 21
M3 - Article
SP - 11436
EP - 11447
SN - 0022538X
AB - Attenuation markers of the candidate dengue 2 (D2) PDK-53 vaccine virus are encoded by mutations that reside outside of the structural gene region of the genome. We engineered nine dengue virus chimeras containing the premembrane (prM) and envelope (E) genes of wild-type D1 16007, D3 16562, or D4 1036 virus within the genetic backgrounds of wild-type D2 16681 virus and the two genetic variants (PDK53-E and PDK53-V) of the D2 PDK-53 vaccine virus. Expression of the heterologous prM-E genes in the genetic backgrounds of the two D2 PDK-53 variants, but not that of wild-type D2 16681 virus, resulted in chimeric viruses that retained PDK-53 characteristic phenotypic markers of attenuation, including small plaque size and temperature sensitivity in LLC-MK[sub 2] cells, limited replication in C6/36 cells, and lack of neurovirulence in newborn ICR mice. Chimeric D2/1, D2/3, and D2/4 viruses replicated efficiently in Vero cells and were immunogenic in AG129 mice. Chimeric D2/1 viruses protected adult AG129 mice against lethal D1 virus challenge. Two tetravalent virus formulations, comprised of either PDK53-E- or PDK53-V-vectored viruses, elicited neutralizing antibody titers in mice against all four dengue serotypes. These antibody titers were similar to the titers elicited by monovalent immunizations, suggesting that viral interference did not occur in recipients of the tetravalent formulations. The results of this study demonstrate that the unique attenuation loci of D2 PDK-53 virus make it an attractive vector for the development of live attenuated flavivirus vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - MOSAICS (Genetics)
KW - DENGUE
KW - VACCINATION
N1 - Accession Number: 11299090; Claire Y.-H. Huang, Paul M. 1; Email Address: chuang1@cdc.gov Butrapet, Siritorn 1,2 Tsuchiya, Kiyotaka R. 1 Bhamarapravati, Natth 2 Gublier, Duane J. 1 Kinney, Richard M. 1; Affiliation: 1: Division of Vector-Borne Infectious Diseases, Centers Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services 2: Center for Vaccine Development, Institute of Science and Technology for Development, Malhidol University, Salaya; Source Info: Nov2003, Vol. 77 Issue 21, p11436; Subject Term: DENGUE viruses; Subject Term: MOSAICS (Genetics); Subject Term: DENGUE; Subject Term: VACCINATION; Number of Pages: 12p; Illustrations: 7 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubin, Steven A.
AU - Amexis, Georgios
AU - Pletnikov, Mikhail
AU - Vanderzanden, Jacqueline
AU - Mauldin, Jeremy
AU - Saunder, Christian
AU - Malik, Tahir
AU - Chumakov, Konstantin
AU - Carbone, Kathryn .
T1 - Changes in Mumps Virus Gene Sequence Associated with Variability in Neurovirulent Phenotype.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003/11//
VL - 77
IS - 21
M3 - Article
SP - 11616
EP - 11624
SN - 0022538X
AB - Mumps virus is highly neurotropic and, prior to widespread vaccination programs, was the major cause of viral meningitis in the United States. Nonetheless, the genetic basis of mumps virus neurotropism and neurovirulence was until recently not understood, largely due to the lack of an animal model. Here, nonneurovirulent (Jeryl Lynn vaccine) and highly neurovirulent (88-1961 wild type) mumps virus strains were passaged in human neural cells or in chicken fibroblast cells with the goal of neuroadapting or neuroattenuating the viruses, respectively. When tested in our rat neurovirulence assay against the respective parental strains, a Jeryl Lynn virus variant with an enhanced propensity for replication (neurotropism) and damage (neurovirulence) in the brain and an 88-1961 wild-type virus variant with decreased neurotropic and neurovirulent properties were recovered. To determine the molecular basis for the observed differences in neurovirulence and neuroattenuation, the complete genomes of the parental strains and their variants were fully sequenced. A comparison at the nucleotide level associated three amino acid changes with enhanced neurovirulence of the neuroadapted vaccine strain: one each in the nucleoprotein, matrix protein, and polymerase and three amino acid changes with reduced neurovirulence of the neuroattenuated wild-type strain: one each in the fusion protein, hemagglutinin-neuraminidase protein, and polymerase. The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - MUMPS
KW - PHENOTYPE
KW - MENINGITIS
KW - UNITED States
N1 - Accession Number: 11299108; Rubin, Steven A. 1; Email Address: rubins@cber.fda.gov Amexis, Georgios 1 Pletnikov, Mikhail 2 Vanderzanden, Jacqueline 1 Mauldin, Jeremy 1 Saunder, Christian 1 Malik, Tahir 1 Chumakov, Konstantin 1 Carbone, Kathryn . 1,2; Affiliation: 1: DVP⁄Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration 2: Departments of Psychiatry and Medicine, Johns Hopkins University; Source Info: Nov2003, Vol. 77 Issue 21, p11616; Subject Term: VIRUSES; Subject Term: MUMPS; Subject Term: PHENOTYPE; Subject Term: MENINGITIS; Subject Term: UNITED States; Number of Pages: 9p; Illustrations: 1 Color Photograph, 3 Black and White Photographs, 2 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaczmarek, Ronald G.
AU - Liu, Chih-Hisn K.
AU - Gross, Thomas P.
T1 - Medical Device Surveillance: Gender Differences in Pulmonary Artery Rupture after Pulmonary Artery Catheterization.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2003/11//
VL - 12
IS - 9
M3 - Article
SP - 931
EP - 935
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - Background: Pulmonary artery (PA) rupture is a rare but often fatal complication of PA catheterization. Methods: An analysis was performed of all the case reports of PA rupture after PA catheterization that were submitted to the Food and Drug Administration's Medical Device Reporting (MDR) system between the years 1991 and 2001. The MDR system is a national passive surveillance system that includes adverse event reports from such sources as manufacturers and healthcare professionals. The Nationwide Inpatient Sample (NIS), a massive, nationally representative database maintained by the Agency for Healthcare Research and Quality, was examined to study patterns of PA catheter use. Results: A total of 71 PA rupture cases were identified from the MDR data. The most likely outcome following PA rupture was death. These PA ruptures were associated with 47 deaths and 24 injuries. The range of reported ages of the cases was between 40 and 91 years, with a mean age of 74 years. Of the 71 PA rupture cases, 52 were in women and 10 were in men, with gender not reported in 9 of the cases. There were significantly more cases in women than expected (Mantel-Haenszel common odds ratio estimate = 5.84, 95% confidence interval = 2.97 - 11.46, p < 0.001). Conclusions: These data suggest that women may be at significantly greater risk of PA rupture after PA catheterization than men. Clinicians must be aware of the potential for this complication of PA catheterization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - THERAPEUTICS
KW - BIOMEDICAL engineering
KW - MEDICAL supplies
KW - MEDICAL care
KW - CATHETERIZATION
N1 - Accession Number: 11743025; Kaczmarek, Ronald G. 1; Email Address: rxk@cdrh.fda.gov Liu, Chih-Hisn K. 1 Gross, Thomas P. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland.; Source Info: Nov2003, Vol. 12 Issue 9, p931; Subject Term: MEDICAL equipment; Subject Term: THERAPEUTICS; Subject Term: BIOMEDICAL engineering; Subject Term: MEDICAL supplies; Subject Term: MEDICAL care; Subject Term: CATHETERIZATION; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 5p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106740594
T1 - Medical device surveillance: gender differences in pulmonary artery rupture after pulmonary artery catheterization.
AU - Kaczmarek RG
AU - Liu CK
AU - Gross TP
Y1 - 2003/11//
N1 - Accession Number: 106740594. Language: English. Entry Date: 20050507. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101159262.
KW - Product Surveillance
KW - Pulmonary Artery -- Injuries
KW - Rupture -- Epidemiology
KW - Swan-Ganz Catheterization -- Adverse Effects
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Databases
KW - Epidemiological Research
KW - Equipment Failure
KW - Female
KW - Male
KW - Mandatory Reporting
KW - Middle Age
KW - Odds Ratio
KW - Risk Factors
KW - Rupture -- Etiology
KW - Sex Factors
KW - Statistical Significance
KW - United States
KW - Human
SP - 931
EP - 935
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
JA - J WOMENS HEALTH (15409996)
VL - 12
IS - 9
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - BACKGROUND: Pulmonary artery (PA) rupture is a rare but often fatal complication of PA catheterization. METHODS: An analysis was performed of all the case reports of PA rupture after PA catheterization that were submitted to the Food and Drug Administration's Medical Device Reporting (MDR) system between the years 1991 and 2001. The MDR system is a national passive surveillance system that includes adverse event reports from such sources as manufacturers and healthcare professionals. The Nationwide Inpatient Sample (NIS), a massive, nationally representative database maintained by the Agency for Healthcare Research and Quality, was examined to study patterns of PA catheter use. RESULTS: A total of 71 PA rupture cases were identified from the MDR data. The most likely outcome following PA rupture was death. These PA ruptures were associated with 47 deaths and 24 injuries. The range of reported ages of the cases was between 40 and 91 years, with a mean age of 74 years. Of the 71 PA rupture cases, 52 were in women and 10 were in men, with gender not reported in 9 of the cases. There were significantly more cases in women than expected (Mantel-Haenszel common odds ratio estimate = 5.84, 95% confidence interval = 2.97 - 11.46, p < 0.001). CONCLUSIONS: These data suggest that women may be at significantly greater risk of PA rupture after PA catheterization than men. Clinicians must be aware of the potential for this complication of PA catheterization.
SN - 1540-9996
AD - HFZ-541, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr, Rockville, MD 20850; rxk@cdrh.fda.gov
U2 - PMID: 14670173.
DO - 10.1089/154099903770948168
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106740594&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Soh, Yunjo
AU - Shin, Mi-Hyun
AU - Lee, Jeong-Sang
AU - Jang, Jung-Hee
AU - Kim, Ok Hee
AU - Kang, Hoil
AU - Surh, Young-Joon
T1 - Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline
JO - Mutation Research/Reviews in Mutation Research
JF - Mutation Research/Reviews in Mutation Research
Y1 - 2003/11//
VL - 544
IS - 2/3
M3 - Article
SP - 129
SN - 13835742
AB - A series of naturally occurring isoquinoline alkaloids, besides their distribution in the environment and presence in certain food stuffs, have been detected in human tissues including particular regions of brain. An example is salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) that not only induces neuronal cell death, but also causes DNA damage and genotoxicity. Tetrahydropapaveroline [THP; 6,7-dihydroxy-1-(3′,4′-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline], a dopamine-derived tetrahydroisoquinoline alkaloid, has been reported to inhibit mitochondrial respiration and is considered to contribute to neurodegeneration implicated in Parkinson’s disease. Since THP bears two catechol moieties, the compound may readily undergo redox cycling to produce reactive oxygen species (ROS) as well as toxic quinoids. In the present study, we have examined the capability of THP to cause oxidative DNA damage and cell death. Incubation of THP with φX174 supercoiled DNA or calf thymus DNA in the presence of cupric ion caused substantial DNA damage as determined by strand scission or formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. THP plus copper-induced DNA damage was ameliorated by some ROS scavengers/antioxidants and catalase. Treatment of C6 glioma cells with THP led to a concentration-dependent reduction in cell viability, which was prevented by the antioxidant N-acetyl-l-cysteine. When these cells were treated with 10 μM THP, c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) were rapidly activated via phosphorylation, whereas activation of extracellular signal-regulated protein kinase (ERK) was inhibited. Furthermore, pretreatment with inhibitors of JNK and p38 MAPK rescued the glioma cells from THP-induced cytotoxicity, suggestive of the involvement of these kinases in THP-induced C6 glioma cell damage. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Reviews in Mutation Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Alkaloids
KW - Tissues
KW - Isoquinoline
KW - Brain
KW - 2′-deoxyguanosine (dGuo)
KW - 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)
KW - 8-(4-chlorophenylthio)-adenosine 3′:5′-cyclic monophosphate (CPT-cAMP)
KW - 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo)
KW - bathocuproinedisulfonic acid sodium salt (BCS)
KW - c-Jun N-terminal kinase (JNK)
KW - extracellular signal-regulated protein kinase (ERK)
KW - glutathione peroxidase (GPx)
KW - l-3,4-dihydroxyphenylalanine (l-DOPA)
KW - malondialdehyde (MDA)
KW - mitogen-activated protein kinase (MAPK)
KW - N-acetyl-l-cysteine (NAC)
KW - Oxidative DNA damage
KW - reactive oxygen species (ROS)
KW - Redox cycling
KW - reduced glutathione (GSH)
KW - superoxide dismutase (SOD)
KW - Tetrahydroisoquinoline
KW - Tetrahydropapaveroline
KW - tetrahydropapaveroline (THP)
N1 - Accession Number: 11538483; Soh, Yunjo 1; Shin, Mi-Hyun 2; Lee, Jeong-Sang 2; Jang, Jung-Hee 2; Kim, Ok Hee 3; Kang, Hoil 3; Surh, Young-Joon 2; Email Address: surh@plaza.snu.ac.kr; Affiliations: 1: Department of Neuroscience, Graduate School of East–West Medical Science, Kyung Hee University, Yongin-si, Kyungki-do, South Korea; 2: Reseach Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea; 3: Korea Food and Drug Administration, Seoul 122-704, South Korea; Issue Info: Nov2003, Vol. 544 Issue 2/3, p129; Subject Term: Alkaloids; Subject Term: Tissues; Subject Term: Isoquinoline; Subject Term: Brain; Author-Supplied Keyword: 2′-deoxyguanosine (dGuo); Author-Supplied Keyword: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT); Author-Supplied Keyword: 8-(4-chlorophenylthio)-adenosine 3′:5′-cyclic monophosphate (CPT-cAMP); Author-Supplied Keyword: 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo); Author-Supplied Keyword: bathocuproinedisulfonic acid sodium salt (BCS); Author-Supplied Keyword: c-Jun N-terminal kinase (JNK); Author-Supplied Keyword: extracellular signal-regulated protein kinase (ERK); Author-Supplied Keyword: glutathione peroxidase (GPx); Author-Supplied Keyword: l-3,4-dihydroxyphenylalanine (l-DOPA); Author-Supplied Keyword: malondialdehyde (MDA); Author-Supplied Keyword: mitogen-activated protein kinase (MAPK); Author-Supplied Keyword: N-acetyl-l-cysteine (NAC); Author-Supplied Keyword: Oxidative DNA damage; Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: Redox cycling; Author-Supplied Keyword: reduced glutathione (GSH); Author-Supplied Keyword: superoxide dismutase (SOD); Author-Supplied Keyword: Tetrahydroisoquinoline; Author-Supplied Keyword: Tetrahydropapaveroline; Author-Supplied Keyword: tetrahydropapaveroline (THP); Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrrev.2003.06.023
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lathers, Claire M.
T1 - Opinion: Challenges and opportunities in animal drug development: a regulatory perspective.
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2003/11//
VL - 2
IS - 11
M3 - Article
SP - 1
PB - Nature Publishing Group
SN - 14741776
AB - Veterinary drugs are important in maintaining the health and productivity of agricultural animals, and the health of companion animals. Although there are many parallels between the development of animal drugs and human drugs, there are also important differences. This article focuses on some key challenges and opportunities for veterinary drug development in the light of the regulatory framework for animal healthcare. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY drugs
KW - DRUG development
KW - VETERINARY pharmacology
KW - ANIMALS
N1 - Accession Number: 11097926; Lathers, Claire M. 1; Email Address: lathers@attglobal.net; Affiliation: 1: Center for Veterinary Medicine, FDA, Office of the Director, HFV-1, 7519 Standish Place, Rockville, Maryland 20855, USA.; Source Info: Nov2003, Vol. 2 Issue 11, p1; Subject Term: VETERINARY drugs; Subject Term: DRUG development; Subject Term: VETERINARY pharmacology; Subject Term: ANIMALS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1038/nrd1229
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106784435
T1 - Device safety. Flying blind with decorative lenses.
AU - Woo E
Y1 - 2003/11//
N1 - Accession Number: 106784435. Language: English. Entry Date: 20031205. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Contact Lenses -- Adverse Effects
KW - Corneal Injuries
KW - Eye Injuries -- Etiology
KW - Adolescence
KW - Adult
KW - Female
KW - Patient Education
SP - 70
EP - 70
JO - Nursing
JF - Nursing
JA - NURSING
VL - 33
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hussain, Maha
AU - Banerjee, Mousumi
AU - Sarkar, Fazlul H.
AU - Djuric, Zora
AU - Pollak, Michael N.
AU - Doerge, Daniel
AU - Fontana, Joseph
AU - Chinni, Sreenivasa
AU - Davis, Joanne
AU - Forman, Jeffrey
AU - Wood, David P.
AU - Kucuk, Omer
T1 - Soy Isoflavones in the Treatment of Prostate Cancer.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2003/11//
VL - 47
IS - 2
M3 - Article
SP - 111
EP - 117
PB - Taylor & Francis Ltd
SN - 01635581
AB - Epidemiologicat studies suggest an inverse association between soy intake and prostate cancer (Pca) risk. We have previously observed that soy isoflavone genistein induces apoptosis and inhibits growth of both androgen-sensitire and androgen-independent Pca cells in vitro. To determine the clinical effects of soy isoflavones on Pca we conducted a pilot study in patients with Pca who had rising serum prostate-specific antigen (PSA) levels. Patients with Pca were enrolled in the study if they had either newly diagnosed and untreated disease under watchful waiting with rising PSA (group I) or had increasing serum PSA following local therapy (group II) or while receiving hormone therapy (group III). The study intervention consisted of 100 mg of soy isoflavone (Novasoy®) taken by mouth twice daily for a minimum of 3 or maximum of 6 mo. Forty-one patients were enrolled (4 in group I, 18 in group II, and 19 in group III) and had a median PSA level of 13.3 ng/ml. Thirty-nine patients could be assessed for response. Soy isoflavone supplementation was given for a median of 5.5 (range 0.8–6) mo per patient. Although there were no sustained decreases in PSA qualifying for a complete or partial response, stabilization of the PSA occurred in 83% of patients in hormome-sensitive (group II) and 35% of hormome-refractory (group III) patients. There was a decrease in the rate of the rise of serum PSA in the whole group (P = 0.01) with rates of rise decreasing from 14 to 6% in group II (P = 0.21) and from 31 to 9% in group III (P = 0.05) following the soy isoflavone intervention. Serum genistein and daidzein levels increased during supplementation from O.11 to 0.65 μM (P = 0.00002) and from O.11 to 0.51 μM (P = 0.00001), respectively. No significant changes were observed in serum levels of testosterone, IGF-1, IGFBP-3, or 5-OHmdU. These data suggest that soy isoflavones may benefit some patients with Pea. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOYFOODS
KW - ISOFLAVONES
KW - PROSTATE cancer
KW - APOPTOSIS
KW - CANCER treatment
KW - THERAPEUTICS
N1 - Accession Number: 12980181; Hussain, Maha 1 Banerjee, Mousumi 2 Sarkar, Fazlul H. 3 Djuric, Zora 1 Pollak, Michael N. 4 Doerge, Daniel 5 Fontana, Joseph 1,6 Chinni, Sreenivasa 3 Davis, Joanne 3 Forman, Jeffrey 7 Wood, David P. 8 Kucuk, Omer 1; Affiliation: 1: Division of Hematology and Oncology, Wayne State University and the Barbara Karmanos Cancer Institute, Detroit 2: Center for Healthcare Effectiveness Research, Detroit, MI 3: Department of Pathology, Wayne State University Wayne State University and the Barbara Karmanos Cancer Institute Detroit, MI 4: Department of Medicine, McGill University and Jewish General Hospital, Montreal, Quebec, Canada 5: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 6: VA Medical Center, Wayne State University and the Barbara Karmanos Cancer Institute, Detroit 7: Department of Radiation Oncology, Wayne State University and the Barbara Karmanos Cancer Institute, Detroit, MI 8: Department of Urology, Wayne State University and the Barbara Karmanos Cancer Institute, Detroit, MI; Source Info: 2003, Vol. 47 Issue 2, p111; Subject Term: SOYFOODS; Subject Term: ISOFLAVONES; Subject Term: PROSTATE cancer; Subject Term: APOPTOSIS; Subject Term: CANCER treatment; Subject Term: THERAPEUTICS; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12980181&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - He, Bin
AU - Rhodes-Brower, Stacey
AU - Miller, Michael R.
AU - Munson, Albert E.
AU - Germolec, Dori R.
AU - Walker, Vickie R.
AU - Korach, Kenneth S.
AU - Meade, B. Jean
T1 - Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERα
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2003/11//
VL - 192
IS - 3
M3 - Article
SP - 254
SN - 0041008X
AB - Octamethylcyclotetrasiloxane (D4) is a low molecular weight cyclic silicone used in the synthesis of larger silicone polymers and in the formulation of a variety of personal care products. The effects of oral D4 exposure in mice on serum estradiol levels, uterine wet weight, and uterine peroxidase activity were investigated. Additionally, in vitro estrogen receptor binding activity was evaluated. Serum estradiol levels decreased in a dose-dependent manner after exposure to 100 mg/kg to 1000 mg/kg D4. Studies with adrenalectomized animals demonstrated that the decreased serum estradiol levels were not due to elevated serum corticosterone levels. Uterine wet weights in ovariectomized mice were significantly increased in a dose-dependent manner by exposure to 250–1000 mg of D4/kg, but not by exposure to other silicone compounds tested (hexamethylcyclotrisiloxane, decamethylcyclopentasiloxane, decamethyltetrasiloxane, and octaphenylcyclotetrasiloxane). Uterine peroxidase activity, a marker for estrogenic activity, was also significantly increased in D4-exposed mice, but not in mice exposed to the other siloxanes. Pretreating mice with the estrogen receptor antagonist ICI 182,780 completely blocked the D4-induced increase in uterine weight, and ovariectomized estrogen receptor-α knockout mice showed no increases in uterine weights when orally exposed to D4 or estradiol. In an in vitro estrogen receptor binding assay, D4 showed significant competition with 3H-estradiol for binding to estrogen receptor-α, but not estrogen receptor-β. The data presented here indicate that D4 has weak estrogenic activity, and that these effects are mediated through estrogen receptor-α. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mice
KW - Molecular weights
KW - Serum
KW - Estradiol
KW - ERKO
KW - Estrogen receptors
KW - Estrogenic activity
KW - ICI 182,780
KW - Octamethylcyclotetrasiloxane
KW - Uterotrophic assays
N1 - Accession Number: 11098875; He, Bin 1; Rhodes-Brower, Stacey 2; Miller, Michael R. 2; Munson, Albert E. 3; Germolec, Dori R. 4; Walker, Vickie R. 4; Korach, Kenneth S. 4; Meade, B. Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Office of the Director, Morgantown, WV 26505, USA; 2: Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, WV 26506-9142, USA; 3: Health Effects Laboratory Division, Morgantown, WV 26505, USA; 4: National Institute of Environmental Health Sciences, Research Triangle, NC 27709, USA; Issue Info: Nov2003, Vol. 192 Issue 3, p254; Thesaurus Term: Mice; Subject Term: Molecular weights; Subject Term: Serum; Subject Term: Estradiol; Author-Supplied Keyword: ERKO; Author-Supplied Keyword: Estrogen receptors; Author-Supplied Keyword: Estrogenic activity; Author-Supplied Keyword: ICI 182,780; Author-Supplied Keyword: Octamethylcyclotetrasiloxane; Author-Supplied Keyword: Uterotrophic assays; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/S0041-008X(03)00282-5
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pomper, Gregory J.
AU - Rick, Margaret E.
AU - Epstein, Jay S.
AU - Read, Elizabeth J.
AU - Leitman, Susan F.
T1 - Management of severe VWD with cryoprecipitate collected by repeated apheresis of a single dedicated donor.
JO - Transfusion
JF - Transfusion
Y1 - 2003/11//
VL - 43
IS - 11
M3 - Article
SP - 1514
EP - 1521
PB - Wiley-Blackwell
SN - 00411132
AB - Rare and severe forms of VWD are associated with trace or absent VWF. The feasibility of supporting a child with severe VWD from birth through age 12 with cryoprecipitate derived from DDAVP-stimulated plasma exchange of a single dedicated donor is reported. An infant with excessive hemorrhage at circumcision was found to have Type 3 VWD. His father carried an allele with a mutation at the level of VWF mRNA expression but did not have a history of bleeding. Cryoprecipitate was prepared from serial DDAVP-stimulated plasma exchanges of the father. Repeated plasma-exchange donations were performed to provide all of the VWF needed for his son. An average of 14 cryoprecipitate units was prepared from each donation, and the units contained markedly elevated levels of FVIII:C. The cryoprecipitate was stored for up to 102 months. Components tested after more than 8 years of storage showed 48 to 130 percent of original FVIII:C activity. Ninety-seven percent of the bleeding episodes, such as epistaxis, tongue-biting accidents, and other minor lacerations, were successfully managed with a single 50- to 100-percent replacement dose of FVIII. The patient experienced normal growth and development and is free of any long-term sequelae attributable to his disease. Cryoprecipitate prepared by repeated plasma exchange of a VWD carrier provided excellent hemostatic function, even after storage intervals of more than a year. Plasma exchange of a committed donor was a cost-effective and safe option for long-term management of VWD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VON Willebrand disease
KW - HEMAPHERESIS
KW - BLOOD donors
KW - VON Willebrand factor
N1 - Accession Number: 11168498; Pomper, Gregory J. Rick, Margaret E. 1 Epstein, Jay S. 1 Read, Elizabeth J. 1 Leitman, Susan F. 1; Affiliation: 1: From the Departments of Transfusion Medicine and Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health; and the Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.; Source Info: Nov2003, Vol. 43 Issue 11, p1514; Subject Term: VON Willebrand disease; Subject Term: HEMAPHERESIS; Subject Term: BLOOD donors; Subject Term: VON Willebrand factor; Number of Pages: 8p; Document Type: Article
L3 - 10.1046/j.1537-2995.2003.00550.x
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Herman, Bruce A.
AU - Harris, Gerald R.
T1 - Response to “An extended commentary on ‘Models and regulatory considerations for transient temperature rise during diagnostic ultrasound pulses’ by ” by
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
Y1 - 2003/11//
VL - 29
IS - 11
M3 - Letter
SP - 1661
SN - 03015629
N1 - Accession Number: 11538417; Herman, Bruce A.; Email Address: bah@cdrh.fda.gov Harris, Gerald R. 1; Affiliation: 1: Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA; Source Info: Nov2003, Vol. 29 Issue 11, p1661; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.ultrasmedbio.2003.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11538417&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thorpe, S.J.
AU - Sands, D.
AU - Fox, B.
AU - Behr-Gross, M.-E.
AU - Schäffner, G.
AU - Yu, M.W.
T1 - ORIGINAL PAPER A global standard for anti-D immunoglobulin: international collaborative study to evaluate a candidate preparation.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2003/11//
VL - 85
IS - 4
M3 - Article
SP - 313
EP - 321
PB - Wiley-Blackwell
SN - 00429007
AB - The aim of the study was to evaluate a lyophilized anti-D immunoglobulin preparation to serve as a global standard for potency assays of anti-D immunoglobulin products. The candidate global standard, 01/572, was calibrated against the World Health Organization (WHO) International Reference Preparation (IRP) for anti-D immunoglobulin, human (68/419), along with two reserve candidate reference preparations, in an international collaborative study involving 25 laboratories in 15 countries. The United States Food and Drug Administration (US-FDA) Center for Biologics Evaluation and Research (CBER) Standard for anti-D immunoglobulin, Lot 3, was included for comparison. Most laboratories (20/25) performed AutoAnalyser methodology, competitive enzyme-linked immunoassay (EIA) and/or flow cytometry. The overall mean potency of the candidate global standard, 01/572, was 284·5 international units (IU)/ampoule, with an interlaboratory variability, expressed as a percentage geometric coefficient of variation (% gcv), of 9·7. The mean potency of the US Standard was 859·4 IU/ml with an interlaboratory variability of 9·5% gcv, excluding an outlier. The mean potencies of the reserve preparations per ampoule/vial were 110·6 IU and 106·7 IU when calibrated against the IRP, and 112·2 IU and 106·6 IU when calibrated against 01/572, respectively, with interlaboratory % gcv values of 9·6–18·3 (excluding outliers). Preparation 01/572 proved more suitable for use as a global standard than the reserve candidate preparations and was established, with an assigned potency of 285 IU/ampoule, by the WHO as the 2nd International Standard for anti-D immunoglobulin; by FDA-CBER as the Standard for anti-D immunoglobulin, Lot 4; and by the European Directorate for the Quality of Medicines (EDQM) as the 1st Biological Reference Preparation for anti-D immunoglobulin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN D
KW - ANTI-immunoglobulin autoantibodies
KW - BLOOD products
KW - GOLD standard
N1 - Accession Number: 11514562; Thorpe, S.J. 1 Sands, D. 1 Fox, B. 1 Behr-Gross, M.-E. 2 Schäffner, G. 3 Yu, M.W. 4; Affiliation: 1: National Institute for Biological Standards and Control 2: European Directorate for the Quality of Medicine 3: Paul-Ehrlich Institute 4: Center for Biologics Evaluation and Research; Source Info: Nov2003, Vol. 85 Issue 4, p313; Subject Term: IMMUNOGLOBULIN D; Subject Term: ANTI-immunoglobulin autoantibodies; Subject Term: BLOOD products; Subject Term: GOLD standard; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.0042-9007.2003.00367.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11514562&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-16861-003
AN - 2004-16861-003
AU - Curran, Patrick J.
AU - Bollen, Kenneth A.
AU - Chen, Feinian
AU - Paxton, Pamela
AU - Kirby, James B.
T1 - Finite Sampling Properties of the Point Estimates and Confidence Intervals of the RMSEA.
JF - Sociological Methods & Research
JO - Sociological Methods & Research
JA - Sociol Methods Res
Y1 - 2003/11//
VL - 32
IS - 2
SP - 208
EP - 252
CY - US
PB - Sage Publications
SN - 0049-1241
SN - 1552-8294
AD - Curran, Patrick J., Department of Psychology, University of North Carolina, Chapel Hill, NC, US, 27599-3270
N1 - Accession Number: 2004-16861-003. Partial author list: First Author & Affiliation: Curran, Patrick J.; Department of Psychology, University of North Carolina, Chapel Hill, NC, US. Release Date: 20050207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Confidence Limits (Statistics); Error of Measurement; Sampling (Experimental); Statistical Estimation. Minor Descriptor: Computer Simulation. Classification: Statistics & Mathematics (2240). Population: Human (10). References Available: Y. Page Count: 45. Issue Publication Date: Nov, 2003.
AB - A key advantage of the root mean square error of approximation (RMSEA) is that under certain assumptions, the sample estimate has a known sampling distribution that allows for the computation of confidence intervals. However, little is known about the finite sampling behaviors of this measure under violations of these ideal asymptotic conditions. This information is critical for developing optimal criteria for using the RMSEA to evaluate model fit in practice. Using data generated from a computer simulation study, the authors empirically tested a set of theoretically generated research hypotheses about the sampling characteristics of the RMSEA under conditions commonly encountered in applied social science research. The results suggest that both the sample estimates and confidence intervals are accurate for sample sizes of n = 200 and higher, but caution is warranted in the use of these measures at smaller sample sizes, at least for the types of models considered here. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - root mean square error of approximation
KW - confidence intervals
KW - sampling distribution
KW - computer simulation
KW - 2003
KW - Confidence Limits (Statistics)
KW - Error of Measurement
KW - Sampling (Experimental)
KW - Statistical Estimation
KW - Computer Simulation
KW - 2003
DO - 10.1177/0049124103256130
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16861-003&site=ehost-live&scope=site
UR - curran@unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-11099-005
AN - 2003-11099-005
AU - Nigam, Jeannie A. S.
AU - Murphy, Lawrence R.
AU - Swanson, Naomi G.
T1 - Are stress management programs indicators of good places to work? Results of a national survey.
T3 - Stress and Its Management in Occupational Settings
JF - International Journal of Stress Management
JO - International Journal of Stress Management
JA - Int J Stress Manag
Y1 - 2003/11//
VL - 10
IS - 4
SP - 345
EP - 360
CY - US
PB - Educational Publishing Foundation
SN - 1072-5245
SN - 1573-3424
SN - 1-59147-143-5
AD - Nigam, Jeannie A. S., 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45230
N1 - Accession Number: 2003-11099-005. Partial author list: First Author & Affiliation: Nigam, Jeannie A. S.; National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, OH, US. Other Publishers: Kluwer Academic/Human Sciences Press. Release Date: 20040112. Correction Date: 20131007. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. ISBN: 1-59147-143-5. Language: English. Major Descriptor: Employee Assistance Programs; Occupational Stress; Stress Management; Working Conditions. Classification: Promotion & Maintenance of Health & Wellness (3365); Industrial & Organizational Psychology (3600). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Nov, 2003.
AB - Data from a national survey of organizations were used to examine whether there are differences in the quality of worklife among organizations that offer stress management programs (SMPs) and those that do not. After controlling for size and industry, the authors found organizations with SMPs to be more likely to offer programs that encourage employee well-being, safety, and skill development than those without SMPs. However, there was no difference in the number of accidents, harassment complaints, or discrimination complaints. Organizations that offered SMPs also tended to offer other programs (i.e., substance abuse and mental health services) to facilitate worker health and well-being and, in this respect, the presence of an SMP appeared to be an indicator of a better place to work. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - stress management programs
KW - working conditions
KW - 2003
KW - Employee Assistance Programs
KW - Occupational Stress
KW - Stress Management
KW - Working Conditions
KW - 2003
DO - 10.1037/1072-5245.10.4.345
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-11099-005&site=ehost-live&scope=site
UR - ZGY1@cdc.go
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10062-002
AN - 2003-10062-002
AU - Ponizovsky, Alexander M.
AU - Grinshpoon, Alexander
AU - Levav, Itzhak
AU - Ritsner, Michael S.
T1 - Life satisfaction and suicidal attempts among persons with schizophrenia.
JF - Comprehensive Psychiatry
JO - Comprehensive Psychiatry
JA - Compr Psychiatry
Y1 - 2003/11//Nov-Dec, 2003
VL - 44
IS - 6
SP - 442
EP - 447
CY - Netherlands
PB - Elsevier Science
SN - 0010-440X
SN - 1532-8384
AD - Ponizovsky, Alexander M., Mental Health Services, Ministry of Health, 2 Ben Tabai St, 93591, Jerusalem, Israel
N1 - Accession Number: 2003-10062-002. PMID: 14610720 Partial author list: First Author & Affiliation: Ponizovsky, Alexander M.; Sha'ar Menashe Mental Health Center, Hadera, Mental Health Services, Ministry of Health, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. Release Date: 20031208. Correction Date: 20160407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attempted Suicide; Life Satisfaction; Patient History; Quality of Life; Schizophrenia. Minor Descriptor: Patients. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: Israel. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Montgomery-Asberg Depression Rating Scale DOI: 10.1037/t04111-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov-Dec, 2003.
AB - The relationship between subjective quality of life (QOL) and suicide attempts in patients with schizophrenia has been understudied. The current study tested the hypothesis that QOL is negatively associated with a history of suicidality of patients with schizophrenia. QOL, as measured by the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), was investigated in 227 inpatients with LES-DSM-IV diagnosis of schizophrenia with and without a lifetime history of suicide attempts. The statistical analysis included analysis of variance (ANOVA), t tests, and analysis of covariance (ANCOVA). The patients who had attempted suicide multiple times were less satisfied with regard to a larger number of life domains than the nonattempters and the single attempters. The differences in QOL remained significant after adjusting for psychiatric history and current psychopathology variables, e.g., age of onset of the disorder, number and length of hospitalizations, and positive, negative, and depressive symptoms. Dissatisfaction with QOL in general and with reference to four specific domains was associated with repeated suicide attempts. Clinicians should include QOL in the evaluation of patients with schizophrenia that are suspected to be suicidal. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - life satisfaction
KW - suicidal attempts
KW - schizophrenia
KW - quality of life
KW - suicidality history
KW - patients
KW - 2003
KW - Attempted Suicide
KW - Life Satisfaction
KW - Patient History
KW - Quality of Life
KW - Schizophrenia
KW - Patients
KW - 2003
DO - 10.1016/S0010-440X(03)00146-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10062-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-09494-007
AN - 2003-09494-007
AU - Brady, Thomas M.
AU - Visscher, Wendy
AU - Feder, Moshe
AU - Burns, Allison M.
T1 - Maternal drug use and the timing of prenatal care.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2003/11//
VL - 14
IS - 4
SP - 588
EP - 607
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
N1 - Accession Number: 2003-09494-007. PMID: 14619557 Partial author list: First Author & Affiliation: Brady, Thomas M.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, US. Release Date: 20040816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Health Care Services; Mothers; Prenatal Care; Health Care Policy. Minor Descriptor: Age Differences; Cocaine; Pregnancy; Racial and Ethnic Differences. Classification: Promotion & Maintenance of Health & Wellness (3365); Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Nov, 2003.
AB - This paper explores the role of maternal drug use and the timing of prenatal care. The study data were collected from women delivering live births at eight participating hospitals in the Washington, D.C., Metropolitan Area Drug Study. An estimated 16.9 percent of the women in this sample initiated prenatal care in their third trimester or received no prenatal care. After adjusting for age, race/ethnicity, education, parity, and attitude toward pregnancy, cocaine use was strongly associated with the timing of prenatal care. Using multivariable ordinal logistic regression, the data suggest significant barriers to prenatal care for substance abusers, especially cocaine users. Increasing access to prenatal care continues to be an important public health policy objective, particularly in urban areas where substance abuse is prevalent. Health services research must test strategies that address the timing of prenatal care among drug-dependent, urban women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prenatal care timing
KW - maternal drug use
KW - age differences
KW - racio-ethnic differences
KW - health attitudes
KW - cocaine
KW - public health policy
KW - pregnant women
KW - 2003
KW - Drug Abuse
KW - Health Care Services
KW - Mothers
KW - Prenatal Care
KW - Health Care Policy
KW - Age Differences
KW - Cocaine
KW - Pregnancy
KW - Racial and Ethnic Differences
KW - 2003
DO - 10.1353/hpu.2010.0700
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-09494-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10872-003
AN - 2003-10872-003
AU - Conners, Nicola A.
AU - Bradley, Robert H.
AU - Mansell, Leanne Whiteside
AU - Liu, Jeffrey Y.
AU - Roberts, Tracy J.
AU - Burgdorf, Ken
AU - Herrell, James M.
T1 - Children of mothers with serious substance abuse problems: An accumulation of risks.
JF - The American Journal of Drug and Alcohol Abuse
JO - The American Journal of Drug and Alcohol Abuse
JA - Am J Drug Alcohol Abuse
Y1 - 2003/11//
VL - 29
IS - 4
SP - 743
EP - 758
CY - United Kingdom
PB - Taylor & Francis
SN - 0095-2990
SN - 1097-9891
AD - Conners, Nicola A., Pediatrics/Partners for Inclusive Communities, University of Arkansas for Medical Sciences, 2001 Pershing Circle, Suite 300, North Little Rock, AR, US, 72114
N1 - Accession Number: 2003-10872-003. PMID: 14713137 Partial author list: First Author & Affiliation: Conners, Nicola A.; Pediatrics/Partners for Inclusive Communities, University of Arkansas for Medical Sciences, North Little Rock, AR, US. Other Publishers: Informa Healthcare. Release Date: 20040112. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Mothers; Offspring; Risk Factors. Minor Descriptor: Academic Achievement; Adolescent Development; Alcohol Abuse; Childhood Development; Health; Life Experiences; Parental Characteristics. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Nov, 2003.
AB - This study examines the life circumstances and experiences of 4084 children affected by maternal addiction to alcohol or other drugs. The paper will address the characteristics of their caregivers, the multiple risk factors faced by these children, their health and development, and their school performance. Data were collected from mothers at intake into 50 publicly funded residential substance abuse treatment programs for pregnant and parenting women. Findings from this study suggest that children whose mothers abuse alcohol or other drugs confront a high level of risk and are at increased vulnerability for physical, academic, and socioemotional problems. Children affected by maternal addiction are in need of long-term supportive services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse
KW - children
KW - drugs
KW - mothers
KW - caregiver characteristics
KW - risk factors
KW - life experiences
KW - development
KW - school performance
KW - life circumstances
KW - health
KW - alcohol
KW - 2003
KW - Drug Abuse
KW - Mothers
KW - Offspring
KW - Risk Factors
KW - Academic Achievement
KW - Adolescent Development
KW - Alcohol Abuse
KW - Childhood Development
KW - Health
KW - Life Experiences
KW - Parental Characteristics
KW - 2003
DO - 10.1081/ADA-120026258
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10872-003&site=ehost-live&scope=site
UR - connersnicolaa@uams.ed
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10031-004
AN - 2003-10031-004
AU - Aaron, Kaytura Felix
AU - Levine, David
AU - Burstin, Helen R.
T1 - African American Church Participation and Health Care Practices.
JF - Journal of General Internal Medicine
JO - Journal of General Internal Medicine
JA - J Gen Intern Med
Y1 - 2003/11//
VL - 18
IS - 11
SP - 908
EP - 913
CY - United Kingdom
PB - Blackwell Publishing
SN - 0884-8734
SN - 1525-1497
AD - Aaron, Kaytura Felix, Office of Priority Populations Research, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2003-10031-004. Partial author list: First Author & Affiliation: Aaron, Kaytura Felix; Center of Primary Care Research, Agency of Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Springer. Release Date: 20040816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Academy for Health Services Research and Health Policy Annual Research Meeting, Jun, 2001, Atlanta, GA, US. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Blacks; Health Behavior; Health Care Services; Religiosity; Religious Practices. Minor Descriptor: Comorbidity; Dental Treatment; Health; Insurance. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2003.
AB - Objective is to determine 1) the prevalence of church participation; 2) whether church participation influences positive health care practices; and 3) whether gender, age, insurance status, and levels of comorbidity modified these relationships. Our independent variable measured the frequency of church attendance. Dependent variables were: 1) Pap smear; 2) mammogram; and 3) dental visit-all taking place within 2 years; 4) blood pressure measurement within 1 year, 5) having a regular source of care, and 6) no perceived delays in care in the previous year. We controlled for socioeconomic factors and the number of comorbid conditions and also tested for interactions. Thirty-seven percent of community members went to church at least monthly. Church attendance was associated with increased likelihood of positive health care practices by 20% to 80%. Church attendance was related to dental visits. Insuarance status and number of comorbid conditions modified the relationship between church attendance and Pap smear, with increased practices noted for the uninsured, for women with 2 or more comorbid conditions. Church attendance is an important correlate of positive health care practices, especially for the most vulnerable subgroups, the uninsured and chronically ill. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - church attendance
KW - church participation
KW - comorbid conditions
KW - health care practices
KW - socioeconomic factors
KW - insuarance status
KW - African Americans
KW - dental visits
KW - gender
KW - age
KW - insurance status
KW - 2003
KW - Blacks
KW - Health Behavior
KW - Health Care Services
KW - Religiosity
KW - Religious Practices
KW - Comorbidity
KW - Dental Treatment
KW - Health
KW - Insurance
KW - 2003
DO - 10.1046/j.1525-1497.2003.20936.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10031-004&site=ehost-live&scope=site
UR - kfaaron@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-09613-008
AN - 2003-09613-008
AU - Petronis, K. R.
AU - Anthony, J. C.
T1 - Social epidemiology, infra-neighbourhood correlation, and generalised estimating equations.
JF - Journal of Epidemiology and Community Health
JO - Journal of Epidemiology and Community Health
JA - J Epidemiol Community Health
Y1 - 2003/11//
VL - 57
IS - 11
SP - 914
EP - 914
CY - United Kingdom
PB - BMJ Publishing Group
SN - 0143-005X
AD - Petronis, K. R., Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, 16-105, Rockville, MD, US, 20857
N1 - Accession Number: 2003-09613-008. Other Journal Title: British Journal of Preventive & Social Medicine. Partial author list: First Author & Affiliation: Petronis, K. R.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20040823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Epidemiology; Health; Neighborhoods; Premature Birth; Tobacco Smoking. Minor Descriptor: Blacks; Human Females; Statistical Regression; Whites. Classification: Social Processes & Social Issues (2900). Population: Human (10). Issue Publication Date: Nov, 2003.
AB - Comments on the editorial by J. Merlo, 'Multilevel analytical approaches in social epidemiology: Measures of health variation compared with traditional measures of association' (see record [rid]2003-07033-001[/rid]). In the editorial, the author notes that the paper's generalized estimating equations (GEE) analysis treats 'the intra-neighbourhood correlation as a 'nuisance' that needs to be adjusted in the analysis but not explicitly investigated'. The author is apparently speaking of first order GEEs but the JECH readership may not appreciate that second order GEEs (GEE2) treat the intra-neighborhood and inter-neighborhood correlations into deliberate objects of study and estimation. Although we ourselves deserve absolutely no credit for bio-statistical innovations, the 'alternating logistic regressions' (ALR) approach is a computationally efficient alternative to GEE2 in the case of a binary outcome. As such, it estimates the pair-wise odds ratio, which quantifies the degree to which health conditions, behaviors, or perceptions might cluster within neighborhoods to a degree other than one might expect if these health conditions, behaviors, or perceptions were distributed at random across neighborhoods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social epidemiology
KW - health variation measures
KW - preterm birth
KW - African Americans
KW - whites
KW - cigarette smoking
KW - intra-neighborhood correlation
KW - 2003
KW - Epidemiology
KW - Health
KW - Neighborhoods
KW - Premature Birth
KW - Tobacco Smoking
KW - Blacks
KW - Human Females
KW - Statistical Regression
KW - Whites
KW - 2003
DO - 10.1136/jech.57.11.914
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-09613-008&site=ehost-live&scope=site
UR - kpetroni@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10636-008
AN - 2003-10636-008
AU - Phelan, Kathleen M.
AU - Mosholder, Andrew D.
AU - Lu, Susan
T1 - Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory drugs.
JF - The Journal of Clinical Psychiatry
JO - The Journal of Clinical Psychiatry
JA - J Clin Psychiatry
Y1 - 2003/11//
VL - 64
IS - 11
SP - 1328
EP - 1334
CY - US
PB - Physicians Postgraduate Press
SN - 0160-6689
AD - Mosholder, Andrew D., 5600 Fishers Lane, FDA HFD-430, Rockville, MD, US, 20857
N1 - Accession Number: 2003-10636-008. PMID: 14658947 Other Journal Title: Diseases of the Nervous System. Partial author list: First Author & Affiliation: Phelan, Kathleen M.; Food and Drug Administration, Center for Drug Evaluation and Research, Office of Drug Safety, Rockville, MD, US. Release Date: 20040112. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Anti Inflammatory Drugs; Drug Interactions; Lithium. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 2003.
AB - Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase serum lithium concentrations. We sought to determine whether NSAIDs that selectively inhibit cyclooxygenase (COX) 2 also elevate serum lithium concentrations. Method: The U.S. Food and Drug Administration's Adverse Event Reporting System (AERS) database was searched in January 2003 for reports of interactions between lithium and rofecoxib or celecoxib, the selective COX-2 inhibitors marketed in the United States. Additionally, a literature search was performed using PubMed with the MeSH terms anti-inflammatory agents, nonsteroidal and lithium. Reports of interactions between NSAIDs and lithium were selected for review based on titles of retrieved citations. Results: Eighteen cases of increased serum lithium concentrations after the addition of one of the COX-2 inhibitors to stable lithium therapy were retrieved from AERS, 13 with rofecoxib and 5 with celecoxib. Serum lithium concentration increases of up to 99% and 448% with concomitant celecoxib and rofecoxib use, respectively, were reported. Thirty-six English-language literature articles report interactions between lithium and various NSAIDs... (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - lithium
KW - drug interaction
KW - nonsteroidal anti-inflammatory drugs
KW - rofecoxib
KW - celecoxib
KW - 2003
KW - Anti Inflammatory Drugs
KW - Drug Interactions
KW - Lithium
KW - 2003
DO - 10.4088/JCP.v64n1108
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10636-008&site=ehost-live&scope=site
UR - mosholdera@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-09633-014
AN - 2003-09633-014
AU - Gfroerer, Joseph C.
AU - Tan, Lucilla L.
T1 - Substance Use Among Foreign-Born Youths in the United States: Does the Length of Residence Matter?
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2003/11//
VL - 93
IS - 11
SP - 1892
EP - 1895
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Gfroerer, Joseph C., SAMHSA Office of Applied Studies, 5600 Fishers Lane, Room 16-105, Rockville, MD, US, 20857
N1 - Accession Number: 2003-09633-014. PMID: 14600061 Partial author list: First Author & Affiliation: Gfroerer, Joseph C.; Substance Abuse and Mental Health Services Administration (SAMHSA), Office of Applied Studies, Rockville, MD, US. Release Date: 20040112. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Acculturation; Drug Abuse Prevention; Health Promotion; Immigration. Classification: Drug & Alcohol Rehabilitation (3383); Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Nov, 2003.
AB - The prevention of substance use is a critical component of health promotion among youths. Of the 72.3 million youths under 18 years of age in the United States in 2000, 2.8 million were foreign-born. Research has suggested that foreign-born youths experience increasing risk of substance use as they become assimilated into US society (i.e., become acculturated). This study provides the first national estimates of the prevalence of substance use among foreign-born youths aged 12 to 17 years and explores the association between acculturation, defined as the length of residence in the United States, and substance use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - American society
KW - substance use prevention
KW - acculturation
KW - foreign born youth
KW - residence length
KW - 2003
KW - Acculturation
KW - Drug Abuse Prevention
KW - Health Promotion
KW - Immigration
KW - 2003
DO - 10.2105/AJPH.93.11.1892
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-09633-014&site=ehost-live&scope=site
UR - jgfroere@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - James, S. Jill
AU - Pogribny, Igor P.
AU - Pogribna, Marta
AU - Miller, Barbara J.
AU - Jernigan, Stefanie
AU - Melnyk, Stepan
T1 - Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003/11/02/Nov2003 Supplement 1
VL - 133
IS - 11
M3 - Article
SP - 3740S
EP - 3747S
SN - 00223166
AB - Using the folate/methyl-deficient rat model of hepatocarcinogenesis, we obtained evidence that may provide new insights into a major unresolved paradox in DNA methylation and cancer research: the mechanistic basis for genome-wide hypomethylation despite an increase in DNA methyltransferase activity and gene-specific regional hypermethylation. Previous studies revealed that the methyltransferase binds with higher affinity to DNA strand breaks, gaps, abasic sites, and uracil than it does to its cognate hemimethylated CpG sites, consistent with its ancestral function as a DNA repair enzyme. These same DNA lesions are an early occurrence in models of folate and methyl deficiency and are often present in human preneoplastic cells. We hypothesized that the high-affinity binding of the maintenance DNA methyltransferase to unrepaired lesions in DNA could sequester available enzyme away from the replication fork and promote passive replication-dependent demethylation. In support of this possibility, we found that lesion-containing DNA is less efficiently methylated than lesion-free DNA from folate/methyl-deficient rats and that an increase in DNA strand breaks precedes DNA hypomethylation. Despite an adaptive increase in DNA methyltransferase activity, hemimethylated DNA from folate/methyl-deficient rats is progressively replaced by doublestranded unmethylated DNA that is resistant to remethylation with dietary methyl repletion. In promoter regions, the inappropriate binding of the DNA methyltransferase to unrepaired lesions or mispairs may promote local histone deacetylation, methylation, and regional hypermethylation associated with tumor suppressor gene silencing. These insights in an experimental model are consistent with the possibility that DNA lesions may be a necessary prerequisite for the disruption of normal DNA methylation patterns in preneoplastic and neoplastic cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMINS
KW - DNA damage
KW - CARCINOGENESIS
N1 - Accession Number: 11574189; James, S. Jill 1; Email Address: jamesjill@uams.edu Pogribny, Igor P. 2 Pogribna, Marta 2 Miller, Barbara J. 2 Jernigan, Stefanie 1 Melnyk, Stepan 1; Affiliation: 1: Department of Pediatrics, University of Arkansas for Medical Sciences 2: Division of Biochemical Toxicology, National Center for Toxicological Research; Source Info: Nov2003 Supplement 1, Vol. 133 Issue 11, p3740S; Subject Term: VITAMINS; Subject Term: DNA damage; Subject Term: CARCINOGENESIS; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 13 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11574189&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Kadlubar, Fred F.
T1 - Molecular Epidemiology of Cancer.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003/11/02/Nov2003 Supplement 1
VL - 133
IS - 11
M3 - Abstract
SP - 3849S
EP - 3850S
SN - 00223166
AB - Molecular epidemiology not only provides us with the ability to predict interindividual differences in susceptibility to environmental exposures that lead to clinical disease, but also indicates effective prevention strategies. Biomarkers of susceptibility include polymorphisms in carcinogen and drug metabolism, DNA repair, and genes that control cell growth. Wide variations in carcinogen and drug metabolism are important determinants of individual cancer susceptibility. Such polymorphisms in carcinogen- and drug-metabolizing enzymes may be due to heritable or environmental factors, and the application of metabolic phenotyping and genotyping methods to epidemiologic studies has provided new insights into such gene-environment interactions. Polymorphisms in DNA repair or processing became evident from rare hereditary disorders involving defective repair or chromosomal stability. About 130 different genes are involved in DNA repair, and lower DNA repair proficiency or polymorphisms have recently been associated with increased susceptibility to cancers of the skin, brain, lung, stomach, breast, bladder, head and neck, and colon. Although over 100 genes have been identified that serve as positive or negative regulators of cell growth as well as of the cell cycle and apoptosis, these have been largely associated with rare hereditary disorders involving greatly increased human cancer susceptibility. The common polymorphisms in these genes have not yet received much attention, but studies indicate that these may be associated with breast, endometrial, ovarian, bladder, colon, lung, thyroid, gastric, nasopharyngeal, esophageal, multiple myeloma, and head and neck cancer. It should be emphasized that although these common genetic polymorphisms do not alone confer high individual cancer risk (low penetrance), they involve a large proportion of the population (high prevalence). Thus, their attributable risk can be high because it can affect a larger number of people in comparison with those rare defects (low prevalence) that greatly increase disease risk (high penetrance) but in much fewer individuals (low attributable risk). The combination of several high risk alleles in a single individual (gene-gene interactions) can result in further increases in relative risk. When increased relative risk is combined with carcinogen exposure, the probability of developing cancer becomes quite high. Examples of such multigene-environment interactions from our ongoing molecular epidemiologic studies of colon, breast, and prostate cancer will be presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - MOLECULAR epidemiology
KW - EPIDEMIOLOGY
N1 - Accession Number: 11574216; Kadlubar, Fred F. 1; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arizona; Source Info: Nov2003 Supplement 1, Vol. 133 Issue 11, p3849S; Subject Term: CANCER; Subject Term: MOLECULAR epidemiology; Subject Term: EPIDEMIOLOGY; Number of Pages: 2p; Document Type: Abstract
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11574216&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Yeon-Sook Lee, Neal H.
AU - Joo-Ran Park, Neal H.
AU - Meehye Kim, Neal H.
T1 - Beneficial Effects of Chitosan on the Nutritional Disorders in Rats Exposed to Various Levels of Lead.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2003/11/02/Nov2003 Supplement 1
VL - 133
IS - 11
M3 - Abstract
SP - 3868S
EP - 3868S
SN - 00223166
AB - With increasing industrialization, concerns have arisen about nutritional disorders induced by environmental contaminants such as lead. The aim of this study was to determine the preventive effects of chitosan, which is recognized as a functional food compound, on the nutritional damage in rats exposed to various levels of lead. Male Sprague-Dawley rats were divided into 8 groups (n = 64) and then fed diets containing 3% cellulose (control) or 3% chitosan, each with 4 different lead doses (0, 20, 50, or 100 mg/d) for 4 wk. Lead doses were given 3 times per week by oral administration. There was no significant difference in weight gain and food intake among groups of rats. Serum lead levels in rats increased depending on the administered doses of lead. Rats fed chitosan diets showed lower serum lead concentration than did their respective controls. The effect of chitosan on the serum lead was more beneficial in rats exposed to lower lead (20 mg/d) than in rats exposed to higher lead (50 and 100 mg/d). Histological changes in erythrocytes and liver were also examined. Chitosan tended to reduce numbers of basophilic stippling erythrocytes and improve the histological liver changes in rats given various lead doses. The preventive effects of chitosan on liver damage were stronger in rats with higher lead than those with lower lead. These results indicate that chitosan has beneficial effects on both serum toxicological response and histological damage of erythrocytes and liver induced by the administration of various lead doses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHITOSAN
KW - NUTRITIONALLY induced diseases
KW - LEAD in the body
N1 - Accession Number: 11574270; Yeon-Sook Lee, Neal H. 1 Joo-Ran Park, Neal H. 1 Meehye Kim, Neal H. 2; Affiliation: 1: Department of Food and Nutrition, Seoul National University 2: Department of Food Evaluation, Korea Food and Drug Administration; Source Info: Nov2003 Supplement 1, Vol. 133 Issue 11, p3868S; Subject Term: CHITOSAN; Subject Term: NUTRITIONALLY induced diseases; Subject Term: LEAD in the body; Number of Pages: 1/4p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peterson, Eric D.
AU - Kaul, Padma
AU - Kaczmarek, Ronald G.
AU - Hammill, Bradley G.
AU - Armstrong, Paul W.
AU - Bridges, Charles R.
AU - Ferguson Jr, T. Bruce
T1 - From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2003/11/05/
VL - 42
IS - 9
M3 - Article
SP - 1611
SN - 07351097
AB - : ObjectivesWe sought to examine trends in the use and outcomes of transmyocardial revascularization (TMR) in community practice. We also identified important risk factors for TMR and compared outcomes of TMR combined with coronary artery bypass graft surgery (TMR + CABG) versus bypass alone in patients receiving incomplete revascularization.: BackgroundAlthough it is approved for use as a stand-alone procedure, there are limited data on the outcomes of (TMR + CABG).: MethodsWe identified 3,717 patients receiving TMR at 173 U.S. hospitals participating in the Society of Thoracic Surgeons (STS) National Cardiac Database. Baseline characteristics and outcomes in these patients were compared with those from six published randomized TMR trials. Multivariable logistic regression was used to identify clinical risk factors for mortality with TMR. Risk-adjusted mortality was also compared for TMR + CABG relative to CABG only in patients not amenable to complete traditional revascularization.: ResultsBetween January 1998 and December 2001, the number of STS hospitals performing TMR and total procedural counts increased markedly, driven predominately by more TMR + CABG cases. Overall mortality rates for TMR-alone and TMR + CABG were 6.4% and 4.2%, respectively. Operative risks were significantly higher in those patients with recent myocardial infarction, unstable angina, and depressed ventricular function. Among patients receiving incomplete revascularization, TMR + CABG was not associated with decreased mortality risk compared with CABG alone, adjusted odds ratio 1.11 (95% confidence interval 0.74 to 1.67).: ConclusionsThe use of TMR, and in particular, TMR + CABG, is expanding in community practice. Although procedural risks are high, there is room for optimization through improved patient selection and timing of the procedure. Further studies of TMR + CABG are needed given its growing use and unclear benefits. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOCARDIAL revascularization
KW - CLINICAL trials
KW - SURGERY -- Risk factors
KW - CORONARY artery bypass
KW - confidence interval (CI)
KW - coronary artery bypass graft surgery (CABG)
KW - Duke Clinical Research Institute (DCRI)
KW - Food and Drug Administration (FDA)
KW - myocardial infarction (MI)
KW - odds ratio (OR)
KW - randomized clinical trial (RCT)
KW - Society of Thoracic Surgeons (STS)
KW - transmyocardial revascularization (TMR)
N1 - Accession Number: 11252402; Peterson, Eric D. 1; Email Address: peter016@mc.duke.edu Kaul, Padma 1,2 Kaczmarek, Ronald G. 3 Hammill, Bradley G. 1 Armstrong, Paul W. 2 Bridges, Charles R. 4 Ferguson Jr, T. Bruce 5; Affiliation: 1: Duke Clinical Research Institute, Durham, North Carolina, USA 2: University of Alberta, Edmonton, Canada 3: Food and Drug Administration, Rockville, Maryland, USA 4: University of Pennsylvania, Philadelphia, Pennsylvania, USA 5: Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA; Source Info: Nov2003, Vol. 42 Issue 9, p1611; Subject Term: MYOCARDIAL revascularization; Subject Term: CLINICAL trials; Subject Term: SURGERY -- Risk factors; Subject Term: CORONARY artery bypass; Author-Supplied Keyword: confidence interval (CI); Author-Supplied Keyword: coronary artery bypass graft surgery (CABG); Author-Supplied Keyword: Duke Clinical Research Institute (DCRI); Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: myocardial infarction (MI); Author-Supplied Keyword: odds ratio (OR); Author-Supplied Keyword: randomized clinical trial (RCT); Author-Supplied Keyword: Society of Thoracic Surgeons (STS); Author-Supplied Keyword: transmyocardial revascularization (TMR); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jacc.2003.07.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waisberg, Michael
AU - Joseph, Pius
AU - Hale, Beverley
AU - Beyersmann, Detmar
T1 - Molecular and cellular mechanisms of cadmium carcinogenesis
JO - Toxicology
JF - Toxicology
Y1 - 2003/11/05/
VL - 192
IS - 2/3
M3 - Article
SP - 95
SN - 0300483X
AB - Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure. In mammals, it exerts multiple toxic effects and has been classified as a human carcinogen by the International Agency for Research on Cancer. Cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. Cd2+ does not catalyze Fenton-type reactions because it does not accept or donate electrons under physiological conditions, and it is only weakly genotoxic. Hence, indirect mechanisms are implicated in the carcinogenicity of cadmium. In this review multiple mechanisms are discussed, such as modulation of gene expression and signal transduction, interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species (ROS), inhibition of DNA repair and DNA methylation, role in apoptosis and disruption of E-cadherin-mediated cell–cell adhesion. Cadmium affects both gene transcription and translation. The major mechanisms of gene induction by cadmium known so far are modulation of cellular signal transduction pathways by enhancement of protein phosphorylation and activation of transcription and translation factors. Cadmium interferes with antioxidant defense mechanisms and stimulates the production of reactive oxygen species, which may act as signaling molecules in the induction of gene expression and apoptosis. The inhibition of DNA repair processes by cadmium represents a mechanism by which cadmium enhances the genotoxicity of other agents and may contribute to the tumor initiation by this metal. The disruption of E-cadherin-mediated cell–cell adhesion by cadmium probably further stimulates the development of tumors. It becomes clear that there exist multiple mechanisms which contribute to the carcinogenicity of cadmium, although the relative weights of these contributions are difficult to estimate. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM
KW - HEAVY metals
KW - APOPTOSIS
KW - CARCINOGENS
KW - GENE expression
KW - Apoptosis
KW - Cadmium
KW - Cancer
KW - DNA repair
KW - E-cadherin
KW - Gene regulation
KW - glutathione (GSH)
KW - immediate early response gene (IEG)
KW - metallothionein (MT)
KW - Oxidative stress
KW - Reactive oxygen species
KW - reactive oxygen species (ROS)
N1 - Accession Number: 11113025; Waisberg, Michael 1; Email Address: mwaisberg@ig.com.br Joseph, Pius 2; Email Address: pcj5@cdc.gov Hale, Beverley 1 Beyersmann, Detmar 3; Email Address: beyers@chemie.uni-bremen.de; Affiliation: 1: Department of Land Resource Science, University of Guelph, Guelph, Ont., Canada 2: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA 3: Department of Biology and Chemistry, University of Bremen, FB2, Leobener Str. NW2, Bremen D-28334, Germany; Source Info: Nov2003, Vol. 192 Issue 2/3, p95; Subject Term: CADMIUM; Subject Term: HEAVY metals; Subject Term: APOPTOSIS; Subject Term: CARCINOGENS; Subject Term: GENE expression; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: DNA repair; Author-Supplied Keyword: E-cadherin; Author-Supplied Keyword: Gene regulation; Author-Supplied Keyword: glutathione (GSH); Author-Supplied Keyword: immediate early response gene (IEG); Author-Supplied Keyword: metallothionein (MT); Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: reactive oxygen species (ROS); Number of Pages: 23p; Document Type: Article
L3 - 10.1016/S0300-483X(03)00305-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cuiling Ma, Roger J.
AU - Jin Wang
AU - Jia Luo
T1 - Exposure to Asphalt Fumes Activates Activator Protein-1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Mouse Epidermal Cells.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2003/11/07/
VL - 278
IS - 45
M3 - Article
SP - 44265
EP - 44272
SN - 00219258
AB - Occupational exposure to asphalt fumes may pose a health risk. Experimental studies using animal and in vitro models indicate that condensates from asphalt fumes are genotoxic and can promote skin tumorigenesis. Enhanced activity of activator protein-1 (AP-1) is frequently associated with the promotion of skin tumorigenesis. The current study investigated the effect of exposure to asphalt fumes on AP-1 activation in mouse JB6 P[sup +] epidermal cells and the skin of transgenic mice expressing the AP-1 luciferase reporter gene. Asphalt fumes were generated from a dynamic generation system that simulated road-paving conditions. Exposure to asphalt fumes significantly increased AP-1 activity in JB6 P[sup +] cells as well as in cultured keratinocytes isolated from transgenic mice expressing AP-1 reporter. In addition, topical application of asphalt fumes by painting the tail skin of mice increased AP-1 activity by 14-fold. Exposure to asphalt fumes promoted basal as well as epidermal growth factor-stimulated anchorage-independent growth of JB6 P[sup +] cells in soft agar. It activated phosphatidylinositol 3-kinase and induced phosphorylation of Akt at Ser-473/Thr-308, and concurrently activated downstream p70 S6 kinase as well as glycogen synthase kinase-3β. Asphalt fumes transiently activated c-Jun NH[sub 2]-terminal kinases without affecting extracellular signal-regulated kinases and p38 mitogen-actirated protein kinases. Further study indicated that blockage of phosphatidylinositol 3-kinase activation eliminated asphalt fume-stimulated AP-1 activation and formation of anchorage-independent colonies in soft agar. This is the first report showing that exposure to asphalt fumes can activate AP-1 and intracellular signaling that may promote skin tumorigenesis, thus providing important evidence on the potential involvement of exposure to asphalt fumes in skin carcinogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPHALT
KW - PROTEIN kinases
KW - CELLULAR signal transduction
N1 - Accession Number: 11520348; Cuiling Ma, Roger J. 1,2 Jin Wang 3 Jia Luo 1; Email Address: jluo@hsc.wvu.edu; Affiliation: 1: Department of Microbiology, & Cell Biology, University School of Medicine, Robert C. Byrd Health Science Center, West Virginia 2: Department of Dermatology, Xijing Hospital 3: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, United States Department of Health and Human Services, West Virginia; Source Info: 11/7/2003, Vol. 278 Issue 45, p44265; Subject Term: ASPHALT; Subject Term: PROTEIN kinases; Subject Term: CELLULAR signal transduction; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; Number of Pages: 8p; Illustrations: 9 Diagrams, 10 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shoham, Nitza G.
AU - Centola, Michael
AU - Mansfield, Elizabeth
AU - Hull, Keith M.
AU - Wood, Geryl
AU - Wise, Carol A.
AU - Kastner, Daniel L.
T1 - Pyrin binds the PSTPlP1/ CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2003/11/11/
VL - 100
IS - 23
M3 - Article
SP - 13501
EP - 13506
SN - 00278424
AB - Pyrin, the familial Mediterranean fever protein, is found in association with the cytoskeleton in myeloid/monocytic cells and modulates IL-1β processing, NF-κB activation, and apoptosis. These effects are mediated in part through cognate interactions with the adaptor protein ASC, which shares an N-terminal motif with pyrin. We sought additional upstream regulators of inflammation by using pyrin as the bait in yeast two-hybrid assays. We now show that proline serine threonine phosphatase-interacting protein [PSTPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal organization, also interacts with pyrin. Recently, PSTPIP1/CD2BP1 mutations were shown to cause the syndrome of pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA), a dominantly inherited autoinflammatory disorder mediated predominantly by granulocytes. Endogenous PSTPIP1/CD2BP1 and pyrin are coexpressed in monocytes and granulocytes and can be coimmunoprecipitated from THP-1 cells. The B box segment of pyrin was necessary and the B box/coiled-coil segment sufficient for this interaction, whereas the SH3 and coiled-coil domains of PSTPIP1/CD2BP1 were both necessary, but neither was sufficient, for pyrin binding. The Y344F PSTPIP1/ CD2BP1 mutation, which blocks tyrosine phosphorylation, was associated with a marked reduction in pyrin binding in pervanadate-treated cells. PAPA-associated A230T and E250Q PSTPIP1/ CD2BP1 mutations markedly increased pyrin binding as assayed by immunoprecipitation and, relative to WT, these mutants were hyperphosphorylated when coexpressed with c-Abl kinase. Consistent with the hypothesis that these mutations exert a dominantnegative effect on the previously reported activity of pyrin, we found increased IL-1/3 production by peripheral blood leukocytes from a clinically active PAPA patient with the A230T PSTPIP1/ CD2BP1 mutation and in cell lines transfected with both PAPAassociated mutants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERIODIC peritonitis
KW - PROTEINS
KW - CYTOSKELETON
KW - MUTATION (Biology)
N1 - Accession Number: 11681975; Shoham, Nitza G. 1 Centola, Michael 1,2 Mansfield, Elizabeth 1,3 Hull, Keith M. 4 Wood, Geryl 1 Wise, Carol A. 5 Kastner, Daniel L. 1; Email Address: kastnerd@exchange.nih.gov.; Affiliation: 1: Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 2: Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 3: Division of Clinical Laboratory Devices, Food and Drug Administration, Rockville, MD 20850 4: Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 5: Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, TX 75219; Source Info: 11/11/2003, Vol. 100 Issue 23, p13501; Subject Term: PERIODIC peritonitis; Subject Term: PROTEINS; Subject Term: CYTOSKELETON; Subject Term: MUTATION (Biology); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mohan, K.V.K.
AU - Muller, J.
AU - Atreya, C.D.
T1 - The N- and C-Terminal Regions of Rotavirus NSP5 Are the Critical Determinants for the Formation of Viroplasm-Like Structures Independent of NSP2.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003/11/15/
VL - 77
IS - 22
M3 - Article
SP - 12184
EP - 12192
SN - 0022538X
AB - Molecular events and the interdependence of the two rotavirus nonstructural proteins, NSP5 and NSP2, in producing viroplasm-like structures (VLS) were previously evaluated by using transient cellular coexpression of the genes for the two proteins, and VLS domains as well as the NSP2-binding region of NSP5 were mapped in the context of NSP2. Review of the previous studies led us to postulate that NSP2 binding of NSP5 may block the N terminus of NSP5 or render it inaccessible and that any similar N-terminal blockage may render NSP5 alone capable of producing VLS independent of NSP2. This possibility was addressed in this report by using two forms of NSP5-green fluorescent protein (GFP) chimeras wherein GFP is fused at either the N or the C terminus of NSP5 (GFP-NSP5 and NSP5-GFP) and evaluating their VLS-forming capability (by light and electron microscopy) and phosphorylation and multimerization potential independent of NSP2. Our results demonstrate that NSP5 alone can form VLS when the N terminus is blocked by fusion with a nonrotavirus protein (GFP-NSP5) but the C terminus is unmodified. Only GFP-NSP5 was able to undergo hyperphosphorylation and multimerization with the native form of NSP5, emphasizing the importance of an unmodified C terminus for these events. Deletion analysis of NSP5 mapped the essential signals for VLS formation to the C terminus and clearly suggested that hyperphosphorylation of NSP5 is not required for VLS formation. The present study emphasizes in general that when fusion proteins are used for functional studies, constructs that represent fusions at both the N and the C termini of the protein should be evaluated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - VIRAL proteins
KW - GENE expression
N1 - Accession Number: 11489344; Mohan, K.V.K. 1 Muller, J. 2 Atreya, C.D. 1; Email Address: atreya@cber.fda.gov; Affiliation: 1: Section of Viral Pathogenesis and Vaccine Adverse Reactions, Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland 2: Laboratory of Vector-Borne Viral Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland; Source Info: Nov2003, Vol. 77 Issue 22, p12184; Subject Term: ROTAVIRUSES; Subject Term: VIRAL proteins; Subject Term: GENE expression; Number of Pages: 9p; Illustrations: 5 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mandelblatt, Jeanne
AU - Saha, Somnath
AU - Teutsch, Steven
AU - Hoerger, Tom
AU - Siu, Albert L.
AU - Atkins, David
AU - Klein, Jonathan
AU - Helfand, Mark
T1 - The Cost-Effectiveness of Screening Mammography beyond Age 65 Years: A Systematic Review for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2003/11/18/
VL - 139
IS - 10
M3 - Article
SP - 835
EP - E-843
SN - 00034819
AB - Purpose: There are few data on the effects of disease biology and competing mortality on the effectiveness of screening women for breast cancer after age 65 years. The authors performed a review to determine the costs and benefits of mammography screening after age 65 years. Data Sources: Cost-effectiveness articles published between January 1989 and March 2002. Study Selection: Studies were identified by using MEDLINE and the National Health Service Economic Evaluation Database. The authors included research on screening after age 65 years conducted from a societal or government perspective; reviews and analyses of other technologies were excluded. Data Synthesis: 115 studies were identified and 10 met inclusion criteria. One study modeled age-dependent assumptions of disease biology. No study fully captured the potential harms of screening, including anxiety associated with false-positive results, overdiagnosis, and previous knowledge of cancer or living longer with the consequences of treatment. Studies differed in the specific strategies compared and in analytic approaches. On average, extending biennial screening to age 75 or 80 years was estimated to cost $34 000 to $88 000 (2002 U.S. dollars) per life-year gained, compared with stopping screening at age 65 years. Two studies suggested that it was more cost-effective to target healthy women than those with several competing risks for death. Conclusions: Current estimates suggest that biennial breast cancer screening after age 65 years reduces mortality at reasonable costs for women without clinically significant comorbid conditions. More data are needed on disease biology and preferences for benefits and harms in older women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMOGRAMS
KW - COST effectiveness
KW - BREAST cancer
KW - MORTALITY
KW - OLDER women
N1 - Accession Number: 11421675; Mandelblatt, Jeanne 1 Saha, Somnath 2 Teutsch, Steven 3 Hoerger, Tom 4 Siu, Albert L. 5 Atkins, David 6 Klein, Jonathan 7 Helfand, Mark 8; Affiliation: 1: Cancer Center, 2233 Wisconsin Avenue, Suite 317, Washington, DC 20007. 2: Portland Veterans Affairs Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239. 3: Merck & Co., PO Box 4, WP39-168, West Point, PA 19486-0004. 4: Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, NC 27709. 5: Mount Sinai School of Medicine, 1 Gustave L. Levey Place, Box 1070, New York, NY 10029. 6: Agency for Healthcare Research and Quality, 540 Gaither Road, 6th Floor, Rockville, MD 20850. 7: University of Rochester, 601 Elmwood, #69, Rochester, NY 14642. 8: Portland Veterans Affairs Medical Center, 3181 SW Sam Jackson Park Road, Portland, OR 97201.; Source Info: 11/18/2003, Vol. 139 Issue 10, p835; Subject Term: MAMMOGRAMS; Subject Term: COST effectiveness; Subject Term: BREAST cancer; Subject Term: MORTALITY; Subject Term: OLDER women; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lehr, Gary J.
AU - Barry, Thomas L.
AU - Franolic, John D.
AU - Petzinger, Glenn
AU - Scheiner, Peter
T1 - LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2003/11/24/
VL - 33
IS - 4
M3 - Article
SP - 627
SN - 07317085
AB - A gradient elution LC method was developed to separate methoxsalen from three of its known impurities: isopimpinellin, bergapten, and ammidin. The method employs a methanol–6%THF (aq) mobile phase, phenyl column, and detection at 254 nm. The gradient LC procedure was applied to seven lots of methoxsalen from five different manufacturers. Six of the seven lots tested contained isopimpinellin as the major impurity at a concentration range of 0.2–2.5%. Identification of the impurity as isopimpinellin was accomplished by a combination of analytical and preparative LC, atmospheric pressure chemical ionization liquid chromatography/mass spectrometry, and NMR. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance spectroscopy
KW - METHANOL
KW - LIQUID chromatography
KW - IONIZATION (Atomic physics)
KW - Ammidin
KW - Atmospheric ionization mass spectrometry
KW - Bergapten
KW - Furanocoumarins
KW - Impurities
KW - Isopimpinellin
KW - Liquid chromatography
KW - Methoxsalen
KW - NMR spectroscopy
N1 - Accession Number: 11403489; Lehr, Gary J. 1; Email Address: glehr@ora.fda.gov Barry, Thomas L. 1 Franolic, John D. 2 Petzinger, Glenn 1 Scheiner, Peter 3; Affiliation: 1: Department of Health and Human Services, Food and Drug Administration, Northeast Regional Laboratory, 158-15 Liberty Avenue, Jamaica, NY 11433, USA 2: Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, 7500 Standish Place, Rockville, MD 20855, USA 3: Department of Chemistry, York College of the City University of New York, 94-20 Guy Brewer Boulevard, Jamaica, NY 11451, USA; Source Info: Nov2003, Vol. 33 Issue 4, p627; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: METHANOL; Subject Term: LIQUID chromatography; Subject Term: IONIZATION (Atomic physics); Author-Supplied Keyword: Ammidin; Author-Supplied Keyword: Atmospheric ionization mass spectrometry; Author-Supplied Keyword: Bergapten; Author-Supplied Keyword: Furanocoumarins; Author-Supplied Keyword: Impurities; Author-Supplied Keyword: Isopimpinellin; Author-Supplied Keyword: Liquid chromatography; Author-Supplied Keyword: Methoxsalen; Author-Supplied Keyword: NMR spectroscopy; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/S0731-7085(03)00353-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nishizuka, Satoshi
AU - Lu Charboneau, Satoshi
AU - Lynn Young, Satoshi
AU - Major, Sylvia
AU - Reinhold, William C.
AU - Waltham, Mark
AU - Kouros-Mehr, Hosein
AU - Bussey, Kimberly J.
AU - Lee, Jae K.
AU - Espina, Virginia
AU - Munson, Peter J.
AU - Petricoin III., Emanuel
AU - Liotta, Lance A.
AU - Weinstein, John N.
T1 - Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2003/11/25/
VL - 100
IS - 24
M3 - Article
SP - 14229
EP - 14234
SN - 00278424
AB - Because most potential molecular markers and targets are proteins, proteomic profiling is expected to yield more direct answers to functional and pharmacological questions than does transcriptional profiling. To aid in such studies, we have developed a protocol for making reverse-phase protein lysate microarrays with larger numbers of spots than previously feasible. Our first application of these arrays was to profiling of the 60 human cancer cell lines (NCI-60) used by the National Cancer Institute to screen compounds for anticancer activity. Each glass slide microarray included 648 lysate spots representing the NCI-60 cell lines plus controls, each ar 10 two-foid serial dilutions to provide a wide dynamic range. Mouse monoclonal antibodies and the catalyzed signal amplification system were used for immunoquantitation. The signal levels from the >30,000 data points for our first 52 antibodies were analyzed by using P-SCAN and a quantitative dose interpolation method. Clustered image maps revealed biologically interpretable patterns of protein expression. Among the principal early findings from these arrays were two promising pathological markers for distinguishing colon from ovarian adenocarcinomas. When we compared the patterns of protein expression with those we had obtained for the same genes at the mRNA level by using both cDNA and oligonucleotide arrays, a striking regularity appeared: cell-structure-related proteins almost invariably showed a high correlation between mRNA and protein levels across the NCI-60 cell lines, whereas non-cell-structure-related proteins showed poor correlation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - TRANSCRIPTION factors
KW - PHARMACOLOGY
KW - CANCER cells
KW - CELL lines
KW - DNA microarrays
N1 - Accession Number: 11916949; Nishizuka, Satoshi 1 Lu Charboneau, Satoshi 2 Lynn Young, Satoshi 3 Major, Sylvia 1 Reinhold, William C. 1 Waltham, Mark 1 Kouros-Mehr, Hosein 1 Bussey, Kimberly J. 1 Lee, Jae K. 4 Espina, Virginia 2 Munson, Peter J. 3 Petricoin III., Emanuel 5 Liotta, Lance A. 2 Weinstein, John N. 1; Email Address: weinstein@dtpax2.ncifcrf.gov; Affiliation: 1: Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology. 2: Laboratory of Pathology, National Cancer Institute. 3: Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Helath, Bethesda, MD 20892. 4: Department of Helath Evalution Sciences, P. O. Box 800717, University of Virginia School of Medicine, Charlottesville, VA 22908. 5: Tissue Proteomics Unit, Division of Therapeutic proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892.; Source Info: 11/25/2003, Vol. 100 Issue 24, p14229; Subject Term: PROTEOMICS; Subject Term: TRANSCRIPTION factors; Subject Term: PHARMACOLOGY; Subject Term: CANCER cells; Subject Term: CELL lines; Subject Term: DNA microarrays; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.2331323100
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11916949&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakab, Ferenc
AU - Walter, Jolan E.
AU - Berke, Tamas
AU - Matson, David O.
AU - Mitchell, Douglas K.
AU - Szűcs, György
T1 - Molecular characterization and sequence analysis of human astroviruses circulating in Hungary
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2003/11/28/
VL - 39
IS - 2
M3 - Article
SP - 97
SN - 09288244
AB - Human astroviruses (HAstVs) are major pathogens in viral gastroenteritis worldwide. Twenty-five HAstV strains were detected from stool specimens of children hospitalized for acute gastroenteritis in Budapest, Hungary, between 1995 and 1999. Sequence analysis was performed at the 3′ end of the capsid gene to determine genotypic diversity of HAstVs circulating in Hungary. Five different genotypes of HAstVs were identified: HAstV-1 was predominant, followed by types 5, 8, 3 and 4. Two different subtypes of HAstV-1 were detected, but only one at a time in the community. This is the first report on the genetic diversity of HAstVs in Hungary and Central/Eastern Europe. [Copyright &y& Elsevier]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS in children
KW - PATHOGENIC microorganisms
KW - GENETICS
KW - Genotype
KW - Human astrovirus
KW - Molecular sequence analysis
N1 - Accession Number: 11402938; Jakab, Ferenc 1,2,3 Walter, Jolan E. 1 Berke, Tamas 1 Matson, David O. 1 Mitchell, Douglas K. 1 Szűcs, György 2; Email Address: gszucs@main.antszbar.hu; Affiliation: 1: Center for Pediatric Research, Children’s Hospital of The King’s Daughters, Eastern Virginia Medical School, Norfolk, VA, USA 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs 7623, Hungary 3: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary; Source Info: Nov2003, Vol. 39 Issue 2, p97; Subject Term: GASTROENTERITIS in children; Subject Term: PATHOGENIC microorganisms; Subject Term: GENETICS; Author-Supplied Keyword: Genotype; Author-Supplied Keyword: Human astrovirus; Author-Supplied Keyword: Molecular sequence analysis; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0928-8244(03)00236-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emshoff, James
AU - Blakely, Craig
AU - Gray, Denis
AU - Jakes, Susan
AU - Brounstein, Paul
AU - Coulter, Judy
AU - Gardner, Steve
T1 - An ESID Case Study at the Federal Level.
JO - American Journal of Community Psychology
JF - American Journal of Community Psychology
Y1 - 2003/12//
VL - 32
IS - 3/4
M3 - Article
SP - 345
EP - 357
SN - 00910562
AB - The D (dissemination) phase of the ESID model has been often overlooked in our efforts to create innovative and widespread social change. The process of replicating successful social innovations is both a prerequisite for dissemination (in order to assess the consistency of effects) and an obvious outcome of a successful dissemination effort. Fidelity, the extent to which a replicated program is implemented in a manner consistent with the original program model, is an important dimension of replication. This study was designed to provide empirical data related to three questions. Can complex social programs be implemented with fidelity? How much fidelity is appropriate or desired? What are the organizational dynamics of adoption with fidelity? Data were collected from grantees of a national replication initiative funded by the Center for Substance Abuse Prevention. Data suggest that high fidelity can be achieved, at least in the context in which programs are mandated to do so as part of the funding agreement and are given technical assistance in achieving fidelity. Secondly, programs perceived high fidelity as having positive effects on the program and its participants, a finding consistent with a limited assessment of the relationship of program outcomes and fidelity. Finally, much was learned about the human and organizational dynamics of replicating with fidelity. Implications for policy and direction regarding replication are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Community Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REPLICATION (Experimental design)
KW - EXPERIMENTAL design
KW - SOCIAL change
KW - SOCIAL networks
KW - COMMUNITY psychology
KW - SOCIAL psychology
KW - dissemination
KW - fidelity
KW - replication
KW - social innovation.
N1 - Accession Number: 12061530; Emshoff, James 1; Email Address: jemshoff@gsu.edu Blakely, Craig 2 Gray, Denis 3 Jakes, Susan 3 Brounstein, Paul 4 Coulter, Judy 4 Gardner, Steve 4; Affiliation: 1: Department of Psychology Georgia State University, Atlanta, Georgia. 2: Texas A&M University System Health Science Center, College Station, Texas. 3: North Carolina State University, Raleigh, North Carolina. 4: Center for Substance Abuse Prevention.; Source Info: Dec2003, Vol. 32 Issue 3/4, p345; Subject Term: REPLICATION (Experimental design); Subject Term: EXPERIMENTAL design; Subject Term: SOCIAL change; Subject Term: SOCIAL networks; Subject Term: COMMUNITY psychology; Subject Term: SOCIAL psychology; Author-Supplied Keyword: dissemination; Author-Supplied Keyword: fidelity; Author-Supplied Keyword: replication; Author-Supplied Keyword: social innovation.; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106752243
T1 - Healthy People 2010 and Asian Americans/Pacific Islanders: defining a baseline of information.
AU - Ghosh C
Y1 - 2003/12//
N1 - Accession Number: 106752243. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Asians
KW - Cardiovascular Diseases -- Ethnology
KW - Diabetes Mellitus -- Ethnology
KW - Health and Welfare Planning
KW - Health Status
KW - Healthy People 2010
KW - HIV Infections -- Ethnology
KW - Immunization
KW - Infant Mortality
KW - Neoplasms -- Ethnology
KW - Computerized Literature Searching
KW - Data Analysis
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Grants
KW - Health Policy
KW - Literature Review
KW - Medline
KW - Race Factors
KW - Research Priorities
KW - Resource Databases, Health
KW - United States
KW - Human
SP - 2093
EP - 2098
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 93
IS - 12
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: Healthy People 2010: Understanding and Improving Health lists 6 areas of disparity in minority health services: infant mortality, cancer, cardiovascular disease, HIV/AIDS, diabetes, and immunizations. This study compiles existing Asian American and Pacific Islander (AAPI) health data to establish a baseline. METHODS: For federally-sponsored research (1986-2000), the Computer Retrieval of Information on Specific Projects (CRISP) database was analyzed. AAPI initiatives were divided by subpopulation and disparity area. MEDLINE articles (1966-2000) were similarly scrutinized. RESULTS: Few federal health-related grants (0.2%) and MEDLINE articles (0.01%) mention AAPIs. For the 6 disparity areas, significant AAPI data gaps remain. CONCLUSIONS: To reach the Healthy People 2010 goals and have useful data, researchers and grant makers must focus on obtaining baseline data for disaggregated AAPI subgroups.
SN - 0090-0036
AD - Health Resources and Services Administration, US Department of Health and Human Services (DHHS)
U2 - PMID: 14652340.
DO - 10.2105/AJPH.93.12.2093
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Holleran, Julianne L.
AU - Egorin, Merrill J.
AU - Zuhowski, Eleanor G.
AU - Parise, Robert A.
AU - Musser, Steven M.
AU - Pan, Su-shu
T1 - Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2003/12//
VL - 323
IS - 1
M3 - Article
SP - 19
SN - 00032697
AB - Although wortmannin is extensively used in molecular signaling studies, its stability in tissue culture medium has not been assessed precisely. Therefore, we used high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to characterize the decomposition of wortmannin in five commonly used media. Wortmannin was added to medium alone or to medium supplemented with 10% unheated or heat-inactivated fetal bovine serum and incubated at 37 °C. After 0, 5, 10, 20, 35, and 60 min, wortmannin remaining in the medium was quantified, and its decay constant and half-life were calculated. In all media, wortmannin decomposed monoexponentially, with half-lives between 8 and 13 min. HPLC/MS indicated that wortmannin decomposed to materials with m/z 447, 433, 373, and 313. Acidification of material produced by incubation of wortmannin in tissue culture medium or 1 μM NaOH converted the material with m/z 447 back to one that cochromatographed with and had an m/z (429) identical to that of wortmannin. Therefore wortmannin is much less stable in tissue culture medium than previously thought although some apparent loss of wortmannin reflects reversible, pH-dependent opening of the lactone ring of wortmannin. This rapid and complex decomposition of wortmannin argues for care being taken in how it is used in in vitro studies. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUE culture
KW - HIGH performance liquid chromatography
KW - MASS spectrometry
KW - HYDROGEN-ion concentration
KW - HPLC
KW - PI-3 kinase
KW - Wortmannin
N1 - Accession Number: 11319063; Holleran, Julianne L. 1 Egorin, Merrill J. 1,2,3; Email Address: egorinmj@msx.upmc.edu Zuhowski, Eleanor G. 1 Parise, Robert A. 1 Musser, Steven M. 4 Pan, Su-shu 1,3; Affiliation: 1: Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA 2: Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA 3: Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA 4: Instrumentation and Biophysics Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA; Source Info: Dec2003, Vol. 323 Issue 1, p19; Subject Term: TISSUE culture; Subject Term: HIGH performance liquid chromatography; Subject Term: MASS spectrometry; Subject Term: HYDROGEN-ion concentration; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: PI-3 kinase; Author-Supplied Keyword: Wortmannin; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ab.2003.08.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Wei
AU - Backlund, Peter S.
AU - Boykins, Robert A.
AU - Wang, Guiyu
AU - Chen, Hao-Chia
T1 - Susceptibility of the hydroxyl groups in serine and threonine to β-elimination/Michael addition under commonly used moderately high-temperature conditions
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2003/12//
VL - 323
IS - 1
M3 - Article
SP - 94
SN - 00032697
AB - The β-elimination/Michael addition reaction has been employed for the modification of O-acylated and phosphorylated Ser and Thr residues in a variety of derivatives. The modified Ser and Thr can be analyzed by amino acid composition analysis, N-terminal Edman degradation sequence analysis, and tandem mass spectrometric sequencing which generally allows the identification and localization of the phosphorylation or glycosylation sites. However, the reactivity of the free hydroxyl group on serine and threonine by sodium hydroxide-induced β-elimination has not been critically examined. In this study, two analogous phosphopeptides, KMpSTLSYR and KMSpTLSYR, were subjected to β-elimination under the widely used conditions previously reported, followed by sulfite or ethanethiol addition. After treatment of the phosphopeptides in 0.1 N NaOH/0.6 M Na2 SO3 at 37 °C for 24 h, matrix-assisted laser desorption ionization-time of flight mass spectrometric analyses of the products revealed an appreciable mass peak with an additional observed mass of 64 compared to the expected mass from the conversion of phosphate to sulfite. Similarly, treatment of the phosphopeptides in 0.52 N NaOH/1.36 M ethanethiol at 50 °C for 18 h or for even as short as 1 h also yielded additional 44 mass of ethylthiogroup in excess of the expected mass for the modified phosphopeptide. Electrospray ionization tandem mass spectrometric analysis confirms that the modification occurred on the hydroxyl group of Ser and Thr in addition to P-Ser and P-Thr. On the other hand, modification on the free hydroxyl group of Ser or Thr was not detected under the mild condition of 0.1 N NaOH/0.6 M Na2 SO3 at 25 °C for 24 h as previously reported (Li et al., Anal. Chem. 74:5701-5710, 2002). This finding suggests that temperatures above 25 °C and excessive alkalinity should be avoided to prevent the β-elimination of the hydroxyl group of Ser and Thr in peptides. This is of particular concern when employing highly sensitive tandem mass spectrometric methods for the identification and localization of Ser and Thr as modification sites by the β-elimination/Michael addition reaction. The additional modification site(s) may complicate the interpretation of data and lead to an erroneous conclusion. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROXYL group
KW - ADDITION reactions
KW - SERINE
KW - AMINO acids
KW - β
KW - -Elimination/Michael addition reaction
KW - LC-MS/MS
KW - MALDI-TOF
KW - Phosphopeptide
KW - Phosphoserine
KW - Phosphothreonine
N1 - Accession Number: 11319072; Li, Wei 1 Backlund, Peter S. 2 Boykins, Robert A. 3 Wang, Guiyu 1 Chen, Hao-Chia 1; Email Address: chen@helix.nih.gov; Affiliation: 1: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2: Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 3: Laboratory of Biophysics, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Dec2003, Vol. 323 Issue 1, p94; Subject Term: HYDROXYL group; Subject Term: ADDITION reactions; Subject Term: SERINE; Subject Term: AMINO acids; Author-Supplied Keyword: β; Author-Supplied Keyword: -Elimination/Michael addition reaction; Author-Supplied Keyword: LC-MS/MS; Author-Supplied Keyword: MALDI-TOF; Author-Supplied Keyword: Phosphopeptide; Author-Supplied Keyword: Phosphoserine; Author-Supplied Keyword: Phosphothreonine; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ab.2003.08.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shieh, Y. Carol
AU - Baric, Ralph S.
AU - Woods, Jacquelina W.
AU - Calci, Kevin R.
T1 - Molecular Surveillance of Enterovirus and Norwalk-Like Virus in Oysters Relocated to a Municipal-Sewage-Impacted Gulf Estuary.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2003/12//
VL - 69
IS - 12
M3 - Article
SP - 7130
EP - 7136
SN - 00992240
AB - An 18-month survey was conducted to examine the prevalence of enteric viruses and their relationship to indicators in environmentally polluted shellfish. Groups of oysters, one group per 4 weeks, were relocated to a coastal water area in the Gulf of Mexico that is impacted by municipal sewage and were analyzed for enteroviruses, Norwalk-like viruses (NLV), and indicator microorganisms (fecal coliform, Escherichia coli, and male-specific coliphages). The levels of indicator microorganisms were consistent with the expected continuous pollution of the area. Fourteen of the 18 oyster samples were found by reverse transcription (RT)-PCR to harbor NLV and/or enterovirus sequences. Of the four virus-negative oysters, three had exposure to water temperatures of >29°C. Concomitant with these findings, two of these four oysters also accumulated the lowest levels of coliphages. PCR primers targeting pan-enteroviruses and the NLV 95/96-US common subset were utilized; NLV sequences were detected more frequently than those of enteroviruses. Within the 12-month sampling period, NLV and enterovirus sequences were detected in 58 and 42%, respectively, of the oysters (67% of the oysters tested were positive for at least one virus) from a prohibited shellfish-growing area approximately 30 m away from a sewage discharge site. Eight (4.6%) of the 175 NLV capsid nucleotide sequences were heterogeneous among the clones derived from naturally polluted oysters. Overall, enteric viral sequences were found in the contaminated oysters throughout all seasons except hot summer, with a higher prevalence of NLV than enterovirus. Although a high percentage of the oysters harbored enteric viruses, the virus levels were usually less than or equal to 2 logs of RT-PCR-detectable units per gram of oyster meat. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROVIRUSES
KW - OYSTERS
KW - MOLECULAR microbiology
KW - MEXICO
N1 - Accession Number: 11898001; Shieh, Y. Carol 1; Email Address: yshieh@cfsan.fda.gov Baric, Ralph S. 2 Woods, Jacquelina W. 1 Calci, Kevin R. 1; Affiliation: 1: Food and Drug Administration Gulf Coast Seafood Laboratory, Alabama 2: Department of Epidemiology, University of North Carolina; Source Info: Dec2003, Vol. 69 Issue 12, p7130; Subject Term: ENTEROVIRUSES; Subject Term: OYSTERS; Subject Term: MOLECULAR microbiology; Subject Term: MEXICO; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hayes, Joshua R.
AU - English, Linda L.
AU - Carter, Peggy J.
AU - Proescholdt, Terry
AU - Lee, Kyung Y.
AU - Wagner, David D.
AU - White, David G.
T1 - Prevalence and Antimicrobial Resistance of Enterococcus Species Isolated from Retail Meats.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2003/12//
VL - 69
IS - 12
M3 - Article
SP - 7153
EP - 7160
SN - 00992240
AB - From March 2001 to June 2002, a total of 981 samples of retail raw meats (chicken, turkey, pork, and beef) were randomly obtained from 263 grocery stores in Iowa and cultured for the presence of Enterococcus spp. A total of 1,357 enterococcal isolates were recovered from the samples, with contamination rates ranging from 97% of pork samples to 100% of ground beef samples. Enterococcus faecium was the predominant species recovered (61%), followed by E. faecalis (29%), and E. hirae (5.7%). E. faecium was the predominant species recovered from ground turkey (60%), ground beef (65%), and chicken breast (79%), while E. faecalis was the predominant species recovered from pork chops (54%). The incidence of resistance to many production and therapeutic antimicrobials differed among enterococci recovered from retail meat samples. Resistance to quinupristin-dalfopristin, a human analogue of the production drug virginiamycin, was observed in 54, 27, 9, and 18% of E. faecium isolates from turkey, chicken, pork, and beef samples, respectively. No resistance to linezolid or vancomycin was observed, but high-level gentamicin resistance was observed in 4% of enterococci, the majority of which were recovered from poultry retail meats. Results indicate that Enterococcus spp. commonly contaminate retail meats and that dissimilarities in antimicrobial resistance patterns among enterococci recovered from different meat types may reflect the use of approved antimicrobial agents in each food animal production class. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROCOCCUS
KW - MEAT
KW - IOWA
KW - UNITED States
N1 - Accession Number: 11898004; Hayes, Joshua R. 1,2 English, Linda L. 2 Carter, Peggy J. 2 Proescholdt, Terry 2 Lee, Kyung Y. 2 Wagner, David D. 2 White, David G. 2; Email Address: dwhite@cvm.fda.gov; Affiliation: 1: Department of Cell Biology and Molecular Genetics, University of Maryland 2: Center for Veterinary Medicine, U.S. Food and Drug Administration, Maryland; Source Info: Dec2003, Vol. 69 Issue 12, p7153; Subject Term: ENTEROCOCCUS; Subject Term: MEAT; Subject Term: IOWA; Subject Term: UNITED States; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 445210 Meat Markets; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tall, B.D.
AU - Fall, S.
AU - Pereira, M.R.
AU - Ramos-Valle, M.
AU - Curtis, S.K.
AU - Kothary, M.H.
AU - Chu, D.M.T.
AU - Monday, S.R.
AU - Kornegay, L.
AU - Donkar, T.
AU - Prince, D.
AU - Thunberg, R.L.
AU - Shangraw, K.A.
AU - Hanes, D.E.
AU - Khambaty, F.M.
AU - Lampel, K.A.
AU - Bier, J.W.
AU - Bayer, R.C.
T1 - Characterization of Vibrio fluvialis-Like Strains Implicated in Limp Lobster Disease.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2003/12//
VL - 69
IS - 12
M3 - Article
SP - 7435
EP - 7446
SN - 00992240
AB - Studies were undertaken to characterize and determine the pathogenic mechanisms involved in a newly described systemic disease in Homarus americanus (American lobster) caused by a Vibrio fluvialis-like microorganism. Nineteen isolates were obtained from eight of nine lobsters sampled. Biochemically, the isolates resembled V. fluvialis, and the isolates grew optimally at 20°C; none could grow at temperatures above 23°C. The type strain (1AMA) displayed a thermal reduction time (D value) of 5.77 min at 37°C. All of the isolates required at least 1% NaCl for growth. Collectively, the data suggest that these isolates may embody a new biotype. Pulsed-field gel electrophoresis (PFGE) analysis of the isolates revealed five closely related subgroups. Some isolates produced a sheep hemagglutinin that was neither an outer membrane protein nor a metalloprotease. Several isolates possessed capsules. The isolates were highly susceptible to a variety of antibiotics tested. However, six isolates were resistant to erythromycin. Seventeen isolates harbored plasmids. Lobster challenge studies revealed that the 50% lethal dose of a plasmid-positive strain was 100-fold lower than that of a plasmid-negative strain, suggesting that the plasmid may enhance the pathogenicity of these microorganisms in lobsters. Microorganisms that were recovered from experimentally infected lobsters exhibited biochemical and PFGE profiles that were indistinguishable from those of the challenge strain. Tissue affinity studies demonstrated that the challenge microorganisms accumulated in heart and midgut tissues as well as in the hemolymph. Culture supernatants and polymyxin B lysates of the strains caused elongation of CHO cells in tissue culture, suggesting the presence of a hitherto unknown enterotoxin. Both plasmid-positive and plasmid-negative strains caused significant dose-related intestinal fluid accumulations in suckling mice. Absence of viable organisms in the intestinal contents of mice suggests that these microorganisms cause diarrhea in mice by intoxication rather than by an infectious process. Further, these results support the thermal reduction data at 37°C and suggest that the mechanism(s) that led to fluid accumulation in mice differs from the disease process observed in lobsters by requiring neither the persistence of viable microorganisms nor the presence of plasmids. In summary, results of lobster studies satisfy Koch's postulates at the organismal and molecular levels; the findings support the hypothesis that these V. fluvialis-like organisms were responsible for the originally described systemic disease, which is now called limp lobster disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO
KW - AMERICAN lobster
KW - DISEASES
N1 - Accession Number: 11898039; Tall, B.D. 1; Email Address: btall@cfsan.fda.gov Fall, S. 1 Pereira, M.R. 1 Ramos-Valle, M. 1 Curtis, S.K. 1 Kothary, M.H. 1 Chu, D.M.T. 1 Monday, S.R. 1 Kornegay, L. 1 Donkar, T. 1 Prince, D. 2 Thunberg, R.L. 1 Shangraw, K.A. 1 Hanes, D.E. 1 Khambaty, F.M. 1 Lampel, K.A. 1 Bier, J.W. 1 Bayer, R.C. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Maryland 2: The Lobster Institute, University of Maine; Source Info: Dec2003, Vol. 69 Issue 12, p7435; Subject Term: VIBRIO; Subject Term: AMERICAN lobster; Subject Term: DISEASES; Number of Pages: 12p; Illustrations: 6 Black and White Photographs, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Henneberger, Paul K.
AU - Deprez, Ronald D.
AU - Asdigian, Nancy
AU - Oliver, L. Christine
AU - Derk, Susan
AU - Goe, Sandra K.
T1 - Workplace Exacerbation of Asthma Symptoms: Findings from a Population-Based Study in Maine.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 2003/12//
VL - 58
IS - 12
M3 - Article
SP - 781
EP - 788
PB - Taylor & Francis Ltd
SN - 00039896
AB - This article compares the general health features of subjects employed in high-risk jobs with those of subjects who performed low-risk jobs. The effect of exposure level on workplace exacerbation of asthma may be diminished if there is a healthy worker effect, particularly if people with asthma self-select away from high-risk jobs. This potential self-selection by determining whether study participants with asthma were underrepresented in high-risk jobs. In addition, people with asthma who remained in high-risk jobs could potentially have been healthier than individuals who did not remain in similar jobs.
KW - Asthma
KW - Health
KW - Work environment
KW - Asthmatics
KW - Obstructive lung diseases
KW - Maine
KW - asthma
KW - exacerbation
KW - population-based studies
KW - work-related asthma.
N1 - Accession Number: 16677289; Henneberger, Paul K. 1; Email Address: pkho@cdc.gov; Deprez, Ronald D. 2; Asdigian, Nancy 2; Oliver, L. Christine 3; Derk, Susan 1; Goe, Sandra K. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH) Morgantown, West Virginia.; 2: Public Health Research Institute Portland, Maine.; 3: Occupational Health Institute Brookline, Massachusetts.; Issue Info: Dec2003, Vol. 58 Issue 12, p781; Thesaurus Term: Asthma; Thesaurus Term: Health; Subject Term: Work environment; Subject Term: Asthmatics; Subject Term: Obstructive lung diseases; Subject: Maine; Author-Supplied Keyword: asthma; Author-Supplied Keyword: exacerbation; Author-Supplied Keyword: population-based studies; Author-Supplied Keyword: work-related asthma.; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bányai, K.
AU - Jakab, F.
AU - Reuter, G.
AU - Bene, J.
AU - Új, M.
AU - Melegh, B.
AU - Szűcs, G.
T1 - Sequence heterogeneity among human picobirnaviruses detected in a gastroenteritis outbreak.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2003/12//
VL - 148
IS - 12
M3 - Article
SP - 2281
EP - 2291
SN - 03048608
AB - Summary. Human picobirnaviruses characterised in this study were serendipitously detected in a non-bacterial gastroenteritis outbreak when specimens were examined for the presence of human rotaviruses using polyacrylamide gel electrophoresis. Of ten stool samples sent for virological examination, two, three, and one specimens were positive for human caliciviruses, picobirnaviruses, and both viruses, respectively. Partial sequences of the RNA-dependent RNA polymerase gene were determined for three picobirnavirus-positive samples. The sequence identity among these three strains was 60% to 65% for the nucleic acid and 64% to 70% for the deduced amino acid sequences. Phylogenetic analysis revealed that each of the three strains clustered with strains identified in geographically separate areas. In contrast, human calicivirus strains co-incidentally identified, showed complete nucleotide sequence identity. These findings demonstrate a lack of common exposure to or point of source for picobirnavirus infection, suggesting that the outbreak was caused by human caliciviruses. Further studies are needed to determine the etiologic role and to establish the taxonomic basis of picobirnaviruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS
KW - EPIDEMICS
KW - HETEROGENEITY
KW - VIRUSES
KW - ROTAVIRUSES
KW - CALICIVIRUSES
KW - POLYACRYLAMIDE gel electrophoresis
N1 - Accession Number: 16936162; Bányai, K. 1 Jakab, F. 1,2 Reuter, G. 1,2 Bene, J. 3 Új, M. 1 Melegh, B. 3 Szűcs, G. 1,2; Email Address: gszucs@main.antszbar.hu; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pées, Hungary. 2: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary. 3: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Pécs, Hungary.; Source Info: Dec2003, Vol. 148 Issue 12, p2281; Subject Term: GASTROENTERITIS; Subject Term: EPIDEMICS; Subject Term: HETEROGENEITY; Subject Term: VIRUSES; Subject Term: ROTAVIRUSES; Subject Term: CALICIVIRUSES; Subject Term: POLYACRYLAMIDE gel electrophoresis; Number of Pages: 11p; Document Type: Article
L3 - 10.1007/s00705-003-0200-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Dong, Ren G.
AU - Smutz, W. Paul
AU - Schopper, Aaron W.
T1 - Nonlinear and viscoelastic characteristics of skin under compression: experiment and analysis.
JO - Bio-Medical Materials & Engineering
JF - Bio-Medical Materials & Engineering
Y1 - 2003/12//
VL - 13
IS - 4
M3 - Article
SP - 373
EP - 385
PB - IOS Press
SN - 09592989
AB - In physiological loading conditions, the soft tissues in the hands and fingers are predominantly in compression. The goal of the present study was to characterize the nonlinear and time‐dependent behavior of skin in compression. The pigskin samples used in the study were collected from five different animals. The compression tests were performed in confined and unconfined loading configurations and at four different loading speeds (0.5, 1.0, 40, and 400 μm/s). A multi‐axial material model was proposed to simulate the nonlinear and viscoelastic behavior of the skin in compression. The good agreement between the model predictions and experimental data suggests that the mechanical behavior of the skin in compression can be well characterized using the Ogden strain energy potential combined with a time‐integration using a Prony series. Our results show that the stress/strain curve of the skin is much stiffer in confined compression compared to that in unconfined compression, indicating that the compressibility of the skin is small. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN care
KW - CRUSH syndrome
KW - TIME study
KW - VISCOELASTICITY
KW - ELASTICITY (Physiology)
KW - BIOMEDICAL materials
N1 - Accession Number: 11620952; Wu, John Z. 1; Email Address: jwu@edc.gov. Dong, Ren G. 1 Smutz, W. Paul 1 Schopper, Aaron W. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Source Info: 2003, Vol. 13 Issue 4, p373; Subject Term: SKIN care; Subject Term: CRUSH syndrome; Subject Term: TIME study; Subject Term: VISCOELASTICITY; Subject Term: ELASTICITY (Physiology); Subject Term: BIOMEDICAL materials; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen-An Tsai
AU - Huey-miin Hsueh
AU - Chen, James J.
T1 - Estimation of False Discovery Rates in Multiple Testing: Application to Gene Microarray Data.
JO - Biometrics
JF - Biometrics
Y1 - 2003/12//
VL - 59
IS - 4
M3 - Article
SP - 1071
EP - 1081
PB - Wiley-Blackwell
SN - 0006341X
AB - Testing for significance with gene expression data from DNA microarray experiments involves simultaneous comparisons of hundreds or thousands of genes. If R denotes the number of rejections (declared significant genes)and V denotes the number of false rejections, then V/R, if R>0, is the proportion of false rejected hypotheses. This paper proposes a model for the distribution of the number of rejections and the conditional distribution of V given R, V/R. Under the independence assumption, the distribution of R is a convolution of two binomials and the distribution of V/R has a noncentral hypergeometric distribution. Under an equicorrelated model, the distributions are more complex and are also derived. Five false discovery rate probability error measures are considered: FDR=E(V/R), p FDR=E(V/R/R>0)(positive FDR),c FDR=E(V/R/R =r )(conditional FDR), m FDR=E(V )/E(R )(marginal FDR), and e FDR=E(V )/r (empirical FDR).T he p FDR, c FDR, and m FDR are shown to be equivalent under the Bayesian framework, in which the number of true null hypotheses is modeled as a random variable. We present a parametric and a bootstrap procedure to estimate the FDRs. Monte Carlo simulations were conducted to evaluate the performance of these two methods. The bootstrap procedure appears to perform reasonably well, even when the alternative hypotheses are correlated (p =.25). An example from a oxicogenomic microarray experiment is presented for illustration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biometrics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - GENE expression
KW - MATHEMATICAL models
KW - HYPERGEOMETRIC distribution
KW - ERROR analysis (Mathematics)
KW - Bayesian Type I error
KW - Comparison-wise error rate (CWE)
KW - False discovery rate (FDR)
KW - Number of rejections
KW - Number of true null hypotheses
KW - q-value
N1 - Accession Number: 12087791; Chen-An Tsai 1 Huey-miin Hsueh 2 Chen, James J. 1; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, U.S.A. 2: Department of Statistics, National ChengChi University, Taipei, Taiwan; Source Info: Dec2003, Vol. 59 Issue 4, p1071; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: MATHEMATICAL models; Subject Term: HYPERGEOMETRIC distribution; Subject Term: ERROR analysis (Mathematics); Author-Supplied Keyword: Bayesian Type I error; Author-Supplied Keyword: Comparison-wise error rate (CWE); Author-Supplied Keyword: False discovery rate (FDR); Author-Supplied Keyword: Number of rejections; Author-Supplied Keyword: Number of true null hypotheses; Author-Supplied Keyword: q-value; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolins, N.
AU - Lozier, J.
AU - Eggerman, T. L.
AU - Jones, E.
AU - Aguilar-Códova, E.
AU - Vostal, J. G.
T1 - Intravenous administration of replication-incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2003/12//
VL - 123
IS - 5
M3 - Article
SP - 903
EP - 905
PB - Wiley-Blackwell
SN - 00071048
AB - A replication-incompetent adenovirus vector was administered to rhesus macaques at 1, 3 and 6 × 1012 particles/kg doses to investigate its toxicity. Platelet count decrements of 28%, 82% and 90%, respectively, were observed, with corresponding platelet half-lives of 69·0, 25·2 and 22·2 h (compared with 111 h in untreated animals). The platelet decline was equivalent for all three doses for 8 h, and platelet count recovery began as early as 8 h after infusion for low-dose recipients, or as late as 24 h for the medium and high dose recipients. These observations suggest that thrombocytopenia is a saturable, reversible consumptive process. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - RHESUS monkey
KW - BLOOD platelets
KW - THROMBOCYTOPENIA
KW - adenovirus
KW - platelet survival
KW - primates
KW - thrombocytopenia
KW - toxicity
N1 - Accession Number: 11463182; Wolins, N. 1 Lozier, J. 1 Eggerman, T. L. 2 Jones, E. 1 Aguilar-Códova, E. 3 Vostal, J. G. 1; Email Address: vostal@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, FDA 2: National Institute of Diabetes, Digestive and Kidney Disease, NIH, Bethesda, MD 3: Harvard Medical School, Cambridge, MA, USA; Source Info: Dec2003, Vol. 123 Issue 5, p903; Subject Term: ADENOVIRUSES; Subject Term: RHESUS monkey; Subject Term: BLOOD platelets; Subject Term: THROMBOCYTOPENIA; Author-Supplied Keyword: adenovirus; Author-Supplied Keyword: platelet survival; Author-Supplied Keyword: primates; Author-Supplied Keyword: thrombocytopenia; Author-Supplied Keyword: toxicity; Number of Pages: 3p; Document Type: Article
L3 - 10.1046/j.1365-2141.2003.04719.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hingorani, Sunil R.
AU - Petricoin III, Emanuel F.
AU - Maitra, Anirban
AU - Rajapakse, Vinodh
AU - King, Catrina
AU - Jacobetz, Michael A.
AU - Ross, Sally
AU - Conrads, Thomas P.
AU - Veenstra, Timothy D.
AU - Hitt, Ben A.
AU - Kawaguchi, Yoshiya
AU - Johann, Don
AU - Liotta, Lance A.
AU - Crawford, Howard C.
AU - Putt, Mary E.
AU - Jacks, Tyler
AU - Wright, Christopher V.E.
AU - Hruban, Ralph H.
AU - Lowy, Andrew M.
AU - Tuveson, David A.
T1 - Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
JO - Cancer Cell
JF - Cancer Cell
Y1 - 2003/12//
VL - 4
IS - 6
M3 - Article
SP - 437
SN - 15356108
AB - To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRASG12D to progenitor cells of the mouse pancreas. We find that physiological levels of KrasG12D induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer. The PanINs are highly proliferative, show evidence of histological progression, and activate signaling pathways normally quiescent in ductal epithelium, suggesting potential therapeutic and chemopreventive targets for the cognate human condition. At low frequency, these lesions also progress spontaneously to invasive and metastatic adenocarcinomas, establishing PanINs as definitive precursors to the invasive disease. Finally, mice with PanINs have an identifiable serum proteomic signature, suggesting a means of detecting the preinvasive state in patients. [Copyright &y& Elsevier]
AB - Copyright of Cancer Cell is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - CARCINOGENESIS
KW - MICE
KW - PANCREAS
KW - CANCER
N1 - Accession Number: 11786183; Hingorani, Sunil R. 1,2 Petricoin III, Emanuel F. 3 Maitra, Anirban 4 Rajapakse, Vinodh 5 King, Catrina 2 Jacobetz, Michael A. 2 Ross, Sally 5 Conrads, Thomas P. 6 Veenstra, Timothy D. 6 Hitt, Ben A. 7 Kawaguchi, Yoshiya 8 Johann, Don 5 Liotta, Lance A. 5 Crawford, Howard C. 9 Putt, Mary E. 10 Jacks, Tyler 11 Wright, Christopher V.E. 8 Hruban, Ralph H. 4 Lowy, Andrew M. 12 Tuveson, David A. 1,2; Email Address: tuvesond@mail.med.upenn.edu; Affiliation: 1: Department of Medicine, Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA 19104 USA 2: Department of Cancer Biology, Abramson Family Cancer Research Institute, Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA 19104 USA 3: FDA-NCI Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA 4: Departments of Pathology and Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA 5: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892 USA 6: National Cancer Institute Biomedical Proteomics Program, Analytical Chemistry Laboratory, Mass Spectrometry Center, SAIC- Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702 USA 7: Correlogic Systems, Inc., Bethesda, MD 20892 USA 8: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 USA 9: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY, 11794 USA 10: Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 USA 11: Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA 02139 USA 12: Department of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Cincinnati, OH 45219 USA; Source Info: Dec2003, Vol. 4 Issue 6, p437; Subject Term: MUTATION (Biology); Subject Term: CARCINOGENESIS; Subject Term: MICE; Subject Term: PANCREAS; Subject Term: CANCER; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gage, Julia C.
AU - Ferreccio, Catterina
AU - Gonzales, Miguel
AU - Arroyo, Raul
AU - Huivín, Militza
AU - Robles, Sylvia C.
T1 - Follow-up care of women with an abnormal cytology in a low-resource setting
JO - Cancer Detection & Prevention
JF - Cancer Detection & Prevention
Y1 - 2003/12//
VL - 27
IS - 6
M3 - Article
SP - 466
SN - 0361090X
AB - Study purpose: We ascertained the follow-up care after an abnormal cytology (Papanicolaou) screening in the San Martı´n region of Peru´ and assessed the status of women who had not received adequate care. Basic procedures: We identified women with an abnormal cytology and assessed their medical records, laboratory registries, death certificates and interviewed them at home. Re-screening, diagnosis and treatment were offered. Main findings: Only 46 (25%) of the 183 women identified received appropriate follow-up care. At re-screening 31 (34%) had a normal result, 9 (10%) were diagnosed with CIN1 and 50 (56%) had CIN2 or worse. Principal conclusions: In this setting, follow-up care after an abnormal cytology was very poor and could explain the lack of impact of cervical cancer screening. Women with an abnormal cytology constitute a high-risk group that should be a priority for health services. [Copyright &y& Elsevier]
AB - Copyright of Cancer Detection & Prevention is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN -- Health
KW - CERVICAL cancer
KW - PAP test
KW - CYTOLOGY
KW - PERU
KW - Cervical intraepithelial neoplasia/prevention and control
KW - Cervix neoplasms/prevention and control
KW - Developing countries
KW - Mass screening
KW - Peru
KW - Vaginal smears
N1 - Accession Number: 11830391; Gage, Julia C. 1; Email Address: jgage@hrsa.gov Ferreccio, Catterina 2 Gonzales, Miguel 3 Arroyo, Raul 4 Huivín, Militza 4 Robles, Sylvia C. 5; Affiliation: 1: Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD, USA 2: Departamento de Salud Pública, Pontificia Universidad Católica de Chilé, Santiago, Chile 3: Proyecto TATI, San Martín, Perú 4: Dirección Regional de Salud de San Martín, Perú 5: Division on Non Communicable Diseases, Pan American Health Organization, Washington, DC, USA; Source Info: Dec2003, Vol. 27 Issue 6, p466; Subject Term: WOMEN -- Health; Subject Term: CERVICAL cancer; Subject Term: PAP test; Subject Term: CYTOLOGY; Subject Term: PERU; Author-Supplied Keyword: Cervical intraepithelial neoplasia/prevention and control; Author-Supplied Keyword: Cervix neoplasms/prevention and control; Author-Supplied Keyword: Developing countries; Author-Supplied Keyword: Mass screening; Author-Supplied Keyword: Peru; Author-Supplied Keyword: Vaginal smears; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.cdp.2003.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kalluri, Pavani
AU - Crowe, Colleen
AU - Reller, Megan
AU - Gaul, Linda
AU - Hayslett, James
AU - Barth, Suzanne
AU - Eliasberg, Stacey
AU - Ferreira, J.
AU - Holt, Kristin
AU - Bengston, Steve
AU - Hendricks, Kate
AU - Sobel, Jeremy
T1 - An Outbreak of Foodborne Botulism Associated with Food Sold at a Salvage Store in Texas.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003/12//12/1/2003
VL - 37
IS - 11
M3 - Article
SP - 1490
EP - 1495
SN - 10584838
AB - Foodborne botulism is caused by potent neurotoxins of Clostridium botulinum. We investigated a large outbreak of foodborne botulism among church supper attendees in Texas. We conducted a cohort study of attendees and investigated the salvage store that sold the implicated foods. We identified 15 cases of botulism (40%) among 38 church supper attendees. Nine patients (60%) had botulinum toxin type A detected in stool specimens. The diagnosis was delayed in 3 cases. Fifteen (63%) of 24 attendees who ate a chili dish developed botulism (relative risk, undefined; P < .001). The chili dish was prepared with “brand X” or “brand Y” frozen chili, “brand Z” canned chili, and hot dogs. An unopened container of brand X chili yielded type A toxin. Brand X chili was purchased at a salvage store where perishable foods were inadequately refrigerated. Our investigation highlights the need to improve clinicians’ awareness of botulism. More rigorous and more unannounced inspections may be necessary to detect food mishandling at salvage stores. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Food poisoning -- Diagnosis
KW - Clostridium botulinum
KW - Texas
KW - United States
N1 - Accession Number: 11472262; Kalluri, Pavani 1,2; Email Address: pkalluri@cdc.gov; Crowe, Colleen 2; Reller, Megan 2; Gaul, Linda 3; Hayslett, James 1,3; Barth, Suzanne 3; Eliasberg, Stacey 4; Ferreira, J. 4; Holt, Kristin 5; Bengston, Steve 5; Hendricks, Kate 3; Sobel, Jeremy 2; Affiliations: 1: Epidemic Intelligence Service, Epidemiology Program Office; 2: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, MS A-38, 1600 Clifton Rd., Atlanta, Georgia 30030; 3: Texas Department of Health, Austin; 4: Office of Regulatory Affairs, US Food and Drug Administration, Rockville, Maryland; 5: Food Safety and Inspection Service, US Department of Agriculture, Washington, DC; Issue Info: 12/1/2003, Vol. 37 Issue 11, p1490; Thesaurus Term: Foodborne diseases; Subject Term: Food poisoning -- Diagnosis; Subject Term: Clostridium botulinum; Subject: Texas; Subject: United States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Edelman, Philip
AU - Osterloh, John
AU - Pirkle, James
AU - Caudill, Sam P.
AU - Grainger, James
AU - Jones, Robert
AU - Blount, Ben
AU - Calafat, Antonia
AU - Turner, Wayman
AU - Feldman, Debra
AU - Baron, Sherry
AU - Bernard, Bruce
AU - Lushniak, Boris D.
AU - Kelly, Kerry
AU - Prezant, David
T1 - Biomonitoring of Chemical Exposure among New York City Firefighters Responding to the World Trade Center Fire and Collapse.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2003/12//
VL - 111
IS - 16
M3 - Article
SP - 1906
EP - 1911
PB - Superintendent of Documents
SN - 00916765
AB - The collapse of the World Trade Center (WTC) on 11 September 2001 exposed New York City firefighters to smoke and dust of unprecedented magnitude and duration. The chemicals and the concentrations produced from any fire are difficult to predict, but estimates of internal dose exposures can be assessed by the biological monitoring of blood and urine. We analyzed blood and urine specimens obtained from 321 firefighters responding to the WTC fires and collapse for 110 potentially fire-related chemicals. Controls consisted of 47 firefighters not present at the WTC. Sampling occurred 3 weeks after 11 September, while fires were still burning. When reference or background ranges were available, most chemical concentrations were found to be generally low and not outside these ranges. Compared with controls, the exposed firefighters showed significant differences in adjusted geometric means for six of the chemicals and significantly greater detection rates for an additional three. Arrival time was a significant predictor variable for four chemicals. Special Operations Command firefighters (n = 95), compared with other responding WTC firefighters (n = 226), had differences in concentrations or detection rate for 14 of the chemicals. Values for the Special Operations Command firefighters were also significantly different from the control group values for these same chemicals and for two additional chemicals. Generally, the chemical concentrations in the other firefighter group were not different from those of controls. Biomonitoring was used to characterize firefighter exposure at the WTC disaster. Although some of the chemicals analyzed showed statistically significant differences, these differences were generally small. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological monitoring
KW - Smoke
KW - Dust
KW - Environmental health
KW - Fire fighters
KW - September 11 Terrorist Attacks, 2001
KW - World Trade Center (New York, N.Y. : 1970-2001)
N1 - Accession Number: 11822609; Edelman, Philip 1; Email Address: philip.edelman@hhs.gov; Osterloh, John 1; Pirkle, James 1; Caudill, Sam P. 1; Grainger, James 1; Jones, Robert 1; Blount, Ben 1; Calafat, Antonia 1; Turner, Wayman 1; Feldman, Debra 2; Baron, Sherry 2; Bernard, Bruce 2; Lushniak, Boris D. 2; Kelly, Kerry 3; Prezant, David 3,4; Affiliations: 1: Centers for Disease Control and Prevention, National Cancer for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, USA; 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 3: New York City Fire Department Bureau of Health Services, Brooklyn, New York, USA; 4: Department of Pulmonary Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA; Issue Info: Dec2003, Vol. 111 Issue 16, p1906; Thesaurus Term: Biological monitoring; Thesaurus Term: Smoke; Thesaurus Term: Dust; Thesaurus Term: Environmental health; Subject Term: Fire fighters; Subject Term: September 11 Terrorist Attacks, 2001 ; Company/Entity: World Trade Center (New York, N.Y. : 1970-2001); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Crochet, Pierre-Andre
AU - Chen, Junjian Z.
AU - Pons, Jean-Marc
AU - Lebreton, Jean-Dominique
AU - Hebert, Paul D. N.
AU - Bonhomme, François
AU - Smith, T.
T1 - GENETIC DIFFERENTIATION AT NUCLEAR AND MITOCHONDRIAL LOCI AMONG LARGE WHITE-HEADED GULLS: SEX-BIASED INTERSPECIFIC GENE FLOW?
JO - Evolution
JF - Evolution
Y1 - 2003/12//
VL - 57
IS - 12
M3 - Article
SP - 2865
EP - 2878
SN - 00143820
AB - We measured genetic differentiation among species of large white-headed gulls using mitochondrial (cytochrome b haplotypes) and nuclear (microsatellites) markers. Additional information was added using a previously published study of allozymes on the same species. Levels of differentiation among species at nuclear markers are much lower than would be expected for avian species and are not concordant with the level of differentiation in mitochondrial markers. This discrepancy is best explained by a combination of recent species origin and interspecific gene flow after speciation. The data also suggest that female-mediated gene flow is reduced compared to male-mediated gene flow, either due to behavioral bias or due to stronger counterselection of female hybrids in accordance with Haldane's rule for ZW species. Whatever the reasons for the low differentiation of the species' nuclear gene pools, the extensive similarity of their nuclear genome demonstrates that selection on a limited number of characters is an important factor in establishing and maintaining clear-cut phenotypic differences between these species and suggests that the number of loci involved in this process is quite low. This situation may not be exceptional in birds, indeed a number of studies have found similarly low level of differentiation in nuclear markers among congeneric bird species, although usually based on a single set of markers. Because hybridization is a widespread phenomenon in birds, many of these cases might be due to interspecific gene flow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Evolution is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL genetics
KW - GULLS
KW - CYTOCHROME b
KW - BIOCHEMICAL markers
KW - ISOENZYMES
KW - HYBRIDIZATION
KW - MICROSATELLITES (Genetics)
KW - MITOCHONDRIAL DNA
KW - Allozymes
KW - birds
KW - Haldane's rule
KW - hybridization
KW - microsatellites
KW - mitochondrial DNA
KW - speciation
N1 - Accession Number: 12476692; Crochet, Pierre-Andre 1,2,3; Email Address: crochet@cefe.cnrs-mop.fr Chen, Junjian Z. 4,5; Email Address: jjchen@nctr.fda.gov Pons, Jean-Marc 6 Lebreton, Jean-Dominique 2 Hebert, Paul D. N. 7 Bonhomme, François 1 Smith, T.; Affiliation: 1: Laboratoire Génome, Populations, Interactions, CNRS UMR 5000, Université Montpellier II, Place E. Bataillon, F-34095 Montpellier cedex 5, France 2: CEFE-CNRS, 1919 route de Mende, F-34293 Montpellier cedex 5, France 3: Station Biologique de la Tour du Valat, Le Sambuc, F-13200 Arles, France 4: Department of Zoology, University of Guelph, Guelph, Ontario NIG 2W1, Canada 5: Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079 6: 0rigine, Structure, et Evolution de la Biodiversité, FRE 2695, Département Systématique et Evolution, Muséum national d'Histoire naturelle, 55 rue Buffon, 75005 Paris, France 7: Department of Zoology, University of Guelph, Guelph, Ontario MG 2W1, Canada; Source Info: Dec2003, Vol. 57 Issue 12, p2865; Subject Term: ANIMAL genetics; Subject Term: GULLS; Subject Term: CYTOCHROME b; Subject Term: BIOCHEMICAL markers; Subject Term: ISOENZYMES; Subject Term: HYBRIDIZATION; Subject Term: MICROSATELLITES (Genetics); Subject Term: MITOCHONDRIAL DNA; Author-Supplied Keyword: Allozymes; Author-Supplied Keyword: birds; Author-Supplied Keyword: Haldane's rule; Author-Supplied Keyword: hybridization; Author-Supplied Keyword: microsatellites; Author-Supplied Keyword: mitochondrial DNA; Author-Supplied Keyword: speciation; Number of Pages: 14p; Illustrations: 2 Diagrams, 6 Charts, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nan Mei, Federico
AU - Lee, Jane
AU - Xuejun Sun
AU - Xing, James Z.
AU - Hanson, John
AU - Le, X. Chris
AU - Weinfeld, Michael
T1 - Genetic predisposition to the cytotoxicity of arsenic: the role of DNA damage and ATM.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2003/12//
VL - 17
IS - 15
M3 - Article
SP - 2310
EP - 2312
AB - Discusses whether DNA damage is the primary cause of death when cells are exposed to arsenic. Effectiveness of sodium arsenite to induce double-strand breaks; Analysis of p53 protein levels and phosphorylation in response to sodium arsenite; Fluorescence intensity of phosphorylated histone H2AX&supa;.
KW - DNA damage
KW - MUTATION (Biology)
KW - ARSENIC
KW - P53 protein
KW - DEATH
N1 - Accession Number: 12124256; Nan Mei, Federico 1 Lee, Jane 2 Xuejun Sun 2 Xing, James Z. 3 Hanson, John 4 Le, X. Chris 3; Email Address: xc.le@ualberta.ca Weinfeld, Michael 2; Email Address: michaelw@cancerboard.ab.ca; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA 2: Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2 Canada 3: Department of Public Health Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada 4: Division of Epidemiology, Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2 Canada; Source Info: Dec2003, Vol. 17 Issue 15, p2310; Subject Term: DNA damage; Subject Term: MUTATION (Biology); Subject Term: ARSENIC; Subject Term: P53 protein; Subject Term: DEATH; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1096/fj.02-0093fje
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hariri, A. R.
AU - Weinberger, D. R.
T1 - Commentary Functional neuroimaging of genetic variation in serotonergic neurotransmission.
JO - Genes, Brain & Behavior
JF - Genes, Brain & Behavior
Y1 - 2003/12//
VL - 2
IS - 6
M3 - Article
SP - 341
EP - 349
PB - Wiley-Blackwell
SN - 16011848
AB - Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Genes, Brain & Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN genetics -- Variation
KW - SEROTONINERGIC mechanisms
KW - NEURAL transmission
KW - POLYMORPHISM (Zoology)
KW - EMOTIONS (Psychology)
KW - Amygdala
KW - emotion
KW - FMRI
KW - PET
KW - prefrontal cortex
KW - serotonin
N1 - Accession Number: 11302203; Hariri, A. R. 1,2; Email Address: haririar@upmc.edu Weinberger, D. R. 1; Affiliation: 1: Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA 2: Director, Developmental Imaging Genomics Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, E-729, Pittsburgh, PA 15213-2593, USA; Source Info: Dec2003, Vol. 2 Issue 6, p341; Subject Term: HUMAN genetics -- Variation; Subject Term: SEROTONINERGIC mechanisms; Subject Term: NEURAL transmission; Subject Term: POLYMORPHISM (Zoology); Subject Term: EMOTIONS (Psychology); Author-Supplied Keyword: Amygdala; Author-Supplied Keyword: emotion; Author-Supplied Keyword: FMRI; Author-Supplied Keyword: PET; Author-Supplied Keyword: prefrontal cortex; Author-Supplied Keyword: serotonin; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1046/j.1601-1848.2003.00048.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106744370
T1 - Health indicators in a prison population: asking prisoners.
AU - Lester C
AU - Hamilton-Kirkwood L
AU - Jones NK
Y1 - 2003/12//
N1 - Accession Number: 106744370. Language: English. Entry Date: 20040611. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; UK & Ireland. Instrumentation: Hospital Anxiety and Depression Scale (HADS). NLM UID: 0374646.
KW - Health Behavior
KW - Health Status
KW - Prisoners
KW - Adult
KW - Age Factors
KW - Anxiety
KW - Asians
KW - Blacks
KW - Chi Square Test
KW - Correctional Facilities
KW - Depression
KW - Diet
KW - Educational Status
KW - Employment Status
KW - Health Services Accessibility
KW - Male
KW - P-Value
KW - Pilot Studies
KW - Psychological Tests
KW - Questionnaires
KW - Race Factors
KW - Record Review
KW - Sex Factors
KW - Smoking
KW - Stress, Psychological
KW - Substance Abuse
KW - Survey Research
KW - Wales
KW - Whites
KW - Human
SP - 341
EP - 349
JO - Health Education Journal
JF - Health Education Journal
JA - HEALTH EDUC J
VL - 62
IS - 4
PB - Sage Publications, Ltd.
AB - Objective: To collect information on health determinants directly from prisoners, complementary to a needs assessment.Design: Self-completion multiple-choice questionnaire to a sample based on alternate cells.Setting: Her Majesty's Prison (HMP) Cardiff.Method: Three hundred men received questionnaires with an offer of confidential help, which was accepted by two. Questions included qualifications, previous occupation, drug, alcohol and medical history, smoking, perceived threats, worries, diet, exercise, drugs in prison, access to services, and the Hospital Anxiety and Depression (HAD) scale.Results: Of 133 (44 per cent) who responded, more than half had left school prematurely. Thirty-three (25 per cent) drank 90 alcohol units or more weekly before prison and 91 (68 per cent) used illegal drugs, with 44 (33 per cent) using in prison. Of the 112 (84 per cent) who smoked, 89 (79 per cent) wished to quit. Ninety-one (68 per cent) never took vigorous exercise, and 83 (62 per cent) ate less than three portions of fruit and/or vegetables daily. Only 41(35 per cent) were within the normal HAD range for both anxiety and depression.Conclusion: This study highlights concurrent high levels of adverse health determinants in prisoners. Targeting these determinants should improve health and decrease the chance of returning to criminality on release.
SN - 0017-8969
AD - National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff UK CFl0 3NW; Carolyn.lester@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MyungSil Hwang, J. F.
AU - MooKi Hong, J. F.
AU - JiSun Yang, J. F.
AU - HyoSun Shin, J. F.
AU - HyoMin Lee, J. F.
AU - EunKyung Yoon, J. F.
AU - GunYoung Lee, J. F.
AU - KiHwa Yang, J. F.
T1 - Health Risk Assessment of Lead in the Republic of Korea.
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2003/12//
VL - 9
IS - 7
M3 - Article
SP - 1801
EP - 1812
SN - 10807039
AB - The purpose of this study was to estimate the daily exposure to lead due to food ingestion, air inhalation, and soil ingestion in the Republic of Korea's general population, and to evaluate the level of risk associated with the current lead exposure level using the proportional daily dose (3-4 μg/kg body weight/day) corresponding to the Provisional Tolerable Weekly Intake (PTWI) suggested by the Joint FAO/WHO Expert Committee on Food Additives as the toxicological tolerance level. The estimation of the daily exposure to lead via three pathways including food, soil ingestion and air inhalation was conducted as a chronic exposure assessment For the lead exposure assessment through dietary intake. 1,389 lead residue data for 45 commodities investigated by the Korea Food and Drug Administration during the period 1995-2000 were utilized (KFDA1996,1997,1998). Six hundred seventy-two air monitoring data from 7 major cities during the period 1993-2000 and 4,500 soil residue data at 1,500 sites during the period 1999-2001 were considered for the lead exposure assessment involving air inhalation and soil ingestion, respectively. The total daily exposure to lead was estimated by combining dietary intake, inhaled amount and soil intake corresponding to the typical activity of the general population, which was treated as a group of adults with a body weight of 60 kg. For risk characterization, the daily exposure to lead was compared with the toxicological tolerance level. The level of risk due to lead exposure was calculated using the hazard ratio (HR). The dietary intake of lead was 9.71 × 10-4 mg/kg/day and the total daily exposure level, including air inhalation and soil ingestion, was 9.97 × 10-4 mg/kg/day. The exposure contributions of foods, air and soil induced from the percentage of each media to the total daily exposure were 97.4%, 2.1% and 0.5%. respectively. Of the different commodity groups, the highest contribution to the total exposure came from grain, which represented 47.7% of the total. Additional exposure to lead occurs in certain population groups due to the use of tobacco, alcoholic beverages, and the intake of other foods, all factors not considered in this study. Through the comparison of the daily exposure to lead with the tolerance level based on the PTWI, the hazard ratio was estimated as being 0.25—0.33. This value implies that no increase in blood lead level is to be expected in the general population at the current lead exposure levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Ecological Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - LEAD in the body
KW - LEAD in soils
KW - FOOD additives
KW - LEAD -- Toxicology
KW - POISONOUS gases -- Toxicology
KW - NUTRITION
KW - BODY weight
KW - KOREA
KW - daily exposure
KW - exposure contribution
KW - hazard ratio
KW - lead
KW - PTWI
N1 - Accession Number: 12176104; MyungSil Hwang, J. F. 1 MooKi Hong, J. F. 1 JiSun Yang, J. F. 1 HyoSun Shin, J. F. 2 HyoMin Lee, J. F. 1; Email Address: hmlee@kfda.go.kr EunKyung Yoon, J. F. 1 GunYoung Lee, J. F. 1 KiHwa Yang, J. F. 1; Affiliation: 1: Department of Risk Assessment, Korea Food and Drug Administration, Eunpyung-ku, Seoul, Republic of Korea 2: Dongguk University, Chung-ku, Seoul, Republic of Korea; Source Info: Dec2003, Vol. 9 Issue 7, p1801; Subject Term: HEALTH risk assessment; Subject Term: LEAD in the body; Subject Term: LEAD in soils; Subject Term: FOOD additives; Subject Term: LEAD -- Toxicology; Subject Term: POISONOUS gases -- Toxicology; Subject Term: NUTRITION; Subject Term: BODY weight; Subject Term: KOREA; Author-Supplied Keyword: daily exposure; Author-Supplied Keyword: exposure contribution; Author-Supplied Keyword: hazard ratio; Author-Supplied Keyword: lead; Author-Supplied Keyword: PTWI; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 12p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beiden, Sergey V.
AU - Maloof, Marcus A.
AU - Wagner, Robert F.
T1 - A General Model for Finite-Sample Effects in Training and Testing of Competing Classifiers.
JO - IEEE Transactions on Pattern Analysis & Machine Intelligence
JF - IEEE Transactions on Pattern Analysis & Machine Intelligence
Y1 - 2003/12//
VL - 25
IS - 12
M3 - Article
SP - 1561
EP - 1569
SN - 01628828
AB - The conventional wisdom in the field of statistical pattern recognition (SPR) is that the size of the finite test sample dominates the variance in the assessment of the performance of a classical or neural classifier. The present work shows that this result has only narrow applicability. In particular, when competing algorithms are compared, the finite training sample more commonly dominates this uncertainty. This general problem in SPR is analyzed using a formal structure recently developed for multivariate random-effects receiver operating characteristic (ROC) analysis. Monte Carlo trials within the general model are used to explore the detailed statistical structure of several representative problems in the subfield of computer-aided diagnosis in medicine. The scaling laws between variance of accuracy measures and number of training samples and number of test samples are investigated and found to be comparable to those discussed in the classic text of Fukunaga, but important interaction terms have been neglected by previous authors. Finally, the importance of the contribution of finite trainers to the uncertainties argues for some form of bootstrap analysis to sample that uncertainty. The leading contemporary candidate is an extension of the 0.632 bootstrap and associated error analysis, as opposed to the more commonly used cross-validation. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Pattern Analysis & Machine Intelligence is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATTERN recognition systems
KW - DISCRIMINANT analysis
KW - BOOTSTRAPPING (Statistics)
N1 - Accession Number: 11613017; Beiden, Sergey V. 1 Maloof, Marcus A. 2; Email Address: maloof@cs.georgetown.edu Wagner, Robert F. 1; Email Address: rfw@cdrh.fda.gov; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 2: Department of Computer Science, Georgetown University, Washington, DC; Source Info: Dec2003, Vol. 25 Issue 12, p1561; Subject Term: PATTERN recognition systems; Subject Term: DISCRIMINANT analysis; Subject Term: BOOTSTRAPPING (Statistics); Number of Pages: 9p; Illustrations: 3 Black and White Photographs, 1 Chart, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gammell, Paul M.
AU - Harris, Gerald R.
T1 - IGBT-Based Kilovoltage Pulsers for Ultrasound Measurement Applications.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2003/12//
VL - 50
IS - 12
M3 - Article
SP - 1722
EP - 1728
SN - 08853010
AB - Presents high-voltage pulser designs that offer advantages in some ultrasound measurement applications. Use of the integrated gate bipolar transistors; Power supply; High-voltage supply considerations; Measurement of slewing rates for the nondoubling and doubling pulsers.
KW - ULTRASONIC transducers
KW - INSULATED gate bipolar transistors
KW - HIGH voltages
KW - ELECTRIC power
KW - ELECTRIC circuit analysis
KW - BIPOLAR transistors
N1 - Accession Number: 12314838; Gammell, Paul M. 1; Email Address: pgammell@ieee.org Harris, Gerald R. 2; Email Address: grh@cdrh.fda.gov; Affiliation: 1: Gammell Applied Technologies, Exmore, VA 2: Center for Devices and Radiological Health, U.S. Food and Drug Administration; Source Info: Dec2003, Vol. 50 Issue 12, p1722; Subject Term: ULTRASONIC transducers; Subject Term: INSULATED gate bipolar transistors; Subject Term: HIGH voltages; Subject Term: ELECTRIC power; Subject Term: ELECTRIC circuit analysis; Subject Term: BIPOLAR transistors; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 3 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106754006
T1 - Are mobile speed cameras effective? A controlled before and after study.
AU - Christie SM
AU - Lyons RA
AU - Dunstan FD
AU - Jones SJ
Y1 - 2003/12//
N1 - Accession Number: 106754006. Language: English. Entry Date: 20040709. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Photography -- Equipment and Supplies
KW - Accidents, Traffic -- Prevention and Control
KW - Accidents, Traffic -- Epidemiology
KW - Pretest-Posttest Design
KW - United Kingdom
KW - Data Collection Methods
KW - Time Factors
KW - Odds Ratio
KW - Confidence Intervals
KW - Prospective Studies
KW - Descriptive Statistics
KW - Intervention Trials
KW - Human
SP - 302
EP - 306
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 9
IS - 4
PB - BMJ Publishing Group
AB - OBJECTIVE: To identify the most appropriate metric to determine the effectiveness of mobile speed cameras in reducing road traffic related injuries. DESIGN: Controlled before and after study which compares two methods for examining the local effectiveness of mobile speed cameras-a circular zone around the camera and a route based method to define exposure at various distances from sites. SETTING: South Wales, UK. SUBJECTS: Persons injured by road traffic before and after intervention. INTERVENTION: Use of mobile speed cameras at 101 sites. MAIN OUTCOME MEASURES: Rate ratio of injurious crashes at intervention and control sites. RESULTS: Camera sites had lower than expected numbers of injurious crashes up to 300 metres using circles and up to 500 metres using routes. Routes methods indicated a larger effect than the circles method except in the 100 metres nearest sites. A 500 metre route method was used to investigate the effect within strata of time after intervention, time of day, speed limit, and type of road user injured. The number of injurious crashes after intervention was substantially reduced (rate ratio 0.49, 95% confidence interval 0.42 to 0.57) and sustained throughout two years after intervention. Significant decreases occurred in daytime and night time, on roads with speed limits of 30 and 60-70 miles/hour and for crashes that injured pedestrians, motorcycle users, and car occupants. CONCLUSIONS: The route based method is the better method of measure effectiveness at distances up to 500 metres. This method demonstrates a 51% reduction in injurious crashes.
SN - 1353-8047
AD - National Public Health Service for Wales, Pontypool, Wales, UK
U2 - PMID: 14693888.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106754006&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Raybourne, Richard B.
AU - Williams, Kristina M.
AU - Vogt, Robert
AU - Reissman, Dori B.
AU - Winterton, Brad S.
AU - Rubin, Carol
T1 - Development and Use of an ELISA Test to Detect IgE Antibody to Cry9c following Possible Exposure to Bioengineered Corn.
JO - International Archives of Allergy & Immunology
JF - International Archives of Allergy & Immunology
Y1 - 2003/12//
VL - 132
IS - 4
M3 - Article
SP - 322
EP - 328
SN - 10182438
AB - Background: Starlink[sup TM] , a variety of corn genetically engineered to contain the insecticidal protein Cry9c, had not been approved for human consumption because it possessed some characteristics associated with allergenic proteins. However, in the fall of 2000 cry9c DNA was detected in several corn-containing products, suggesting that Starlink corn had entered the human food supply. Subsequently, consumers, following consumption of corn products, reported a number of adverse health events, possibly consistent with allergic reaction. Methods: To investigate the possibility of allergic reactions due to Cry9c in these consumers an ELISA test was developed for the purpose of detecting IgE antibodies to Cry9c and blood samples were taken from a total of 18 people who self-reported allergic reactions. Sera collected prior to the 1996 development of Starlink were used as negative controls. Results: None of the adverse event sera were found to be reactive with recombinant Cry9c antigen, based on comparison with normal controls. Although a known human positive control serum containing IgE specific for Cry9c was not available, other controls were incorporated into the ELISA protocol, including the use of sera from subjects allergic to other allergens and their homologous antigens (cat, grass, peanut) to validate the IgE detection reagents. Conclusions: While the results do not support the likely occurrence of allergic reactions to Cry9c, such reactions cannot be ruled out, nor can the possibility that sera might react with unique glycosylated epitopes of Cry9c that may be expressed in the corn plant/seed. Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Allergy & Immunology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULIN E
KW - ALLERGY
KW - IMMUNOGLOBULINS
KW - ENZYME-linked immunosorbent assay
KW - PROTEINS
KW - Allergy
KW - Corn
KW - Cry9C
KW - IgE
N1 - Accession Number: 11805923; Raybourne, Richard B. 1; Email Address: richard.raybourne@cfsan.fda.gov Williams, Kristina M. 1 Vogt, Robert 2 Reissman, Dori B. 2 Winterton, Brad S. 2 Rubin, Carol 2; Affiliation: 1: Immunobiology Branch, Food and Drug Administration, Laurel, Md., USA 2: Centers for Disease Control and Prevention, Atlanta, Ga., USA; Source Info: 2003, Vol. 132 Issue 4, p322; Subject Term: IMMUNOGLOBULIN E; Subject Term: ALLERGY; Subject Term: IMMUNOGLOBULINS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: PROTEINS; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Corn; Author-Supplied Keyword: Cry9C; Author-Supplied Keyword: IgE; Number of Pages: 7p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1159/000074899
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106723591
T1 - Acculturation and the health and well-being of U.S. immigrant adolescents.
AU - Yu SM
AU - Huang ZJ
AU - Schwalberg RH
AU - Overpeck M
AU - Kogan MD
Y1 - 2003/12//
N1 - Accession Number: 106723591. Language: English. Entry Date: 20040416. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 9102136.
KW - Acculturation -- In Adolescence
KW - Adolescent Health
KW - Immigrants -- In Adolescence -- United States
KW - Adolescence
KW - Chi Square Test
KW - Child
KW - Confidence Intervals
KW - English as a Second Language
KW - Female
KW - Health Behavior
KW - Logistic Regression
KW - Multiple Regression
KW - Multivariate Analysis
KW - Odds Ratio
KW - Psychological Well-Being
KW - Surveys
KW - United States
KW - Human
SP - 479
EP - 488
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
JA - J ADOLESC HEALTH
VL - 33
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: To examine the association of acculturation, as measured by language spoken at home, with the health, psychosocial, school, and parental risk factors of adolescents of various racial/ethnic groups. METHODS: Using the U.S. component of the 1997-98 World Health Organization Study of Health Behavior in School Children, bivariate and multiple logistic regression analyses were conducted of records for adolescents in four racial/ethnic groups to explore the relationship between the language spoken at home and outcome variables regarding health status and risks, psychosocial and school risk factors, and parental factors. Data were analyzed using Software for the Statistical Analysis of Correlated Data (SUDAAN). RESULTS: Adolescents of all racial and ethnic groups who primarily speak a language other than English at home are at elevated risk for psychosocial risk factors such as alienation from classmates and being bullied, and parental risk factors such as feeling that their parents are not able or willing to help them. Those who speak a combination of languages are also at risk for being bullied and for high parental expectations. Language spoken at home is generally not associated with health and safety measures for adolescents across racial/ethnic groups. CONCLUSIONS: Adolescents whose primary language at home is not English experience higher psychosocial, school, and parental risks than non-Hispanic white English-speakers. New immigrant youths of all races and ethnic groups would potentially benefit from preventive and risk-reduction services.
SN - 1054-139X
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18-41, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 14642710.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Price, W.D.
T1 - Symposium on analytical method challenges for measuring nutrients and antinutrients in plants: Introduction to the symposium.
JO - Journal of Animal Science
JF - Journal of Animal Science
Y1 - 2003/12//
VL - 81
IS - 12
M3 - Article
SP - 3216
EP - 3217
SN - 00218812
AB - Introduces studies presented at the symposium on analytical method challenges for measuring nutrients and antinutrients in plants. Minerals in foodstuffs; Complications in freeing the minerals from the plant matrix in the right oxidation state; Plant fiber methods; Challenges in evaluating the nutritional quality of fiber in the diet.
KW - PLANT nutrients
KW - MINERALS
KW - PLANT fibers
KW - CONFERENCES & conventions
N1 - Accession Number: 11787685; Price, W.D. 1; Email Address: wprice@cvm.fda.gov; Affiliation: 1: Office of Surveillance and Compliance, Center for Veterinary Medicine, Food and Drug Administration; Source Info: Dec2003, Vol. 81 Issue 12, p3216; Subject Term: PLANT nutrients; Subject Term: MINERALS; Subject Term: PLANT fibers; Subject Term: CONFERENCES & conventions; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kunkle, Carey A.
AU - Schmitt, Michael P.
T1 - Analysis of the Corynebacterium diphtheriae DtxR Regulon: Identification of a Putative Siderophore Synthesis and Transport System That Is Similar to the Yersinia High-Pathogenicity Island-Encoded Yersiniabactin Synthesis and Uptake System.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2003/12//
VL - 185
IS - 23
M3 - Article
SP - 6826
EP - 6840
SN - 00219193
AB - The diphtheria toxin repressor, DtxR, is a global iron-dependent regulatory protein in Corynebacterium diphtheriae that controls gene expression by binding to 19-bp operator sequences. To further define the DtxR regulon in C. diphtheriae, a DtxR repressor titration assay (DRTA) was developed and used to identify 10 previously unknown DtxR binding sites. Open reading frames downstream from seven of the newly identified DtxR binding sites are predicted to encode proteins associated with iron or heme transport. Electrophoretic mobility shift assays indicated that DtxR was able to bind to DNA fragments carrying the 19-bp operator regions, and transcriptional analysis of putative promoter elements adjacent to the binding site sequences revealed that most of these regions displayed iron- and DtxR-regulated activity. A putative siderophore biosynthesis and transport operon located downstream from one of the DtxR binding sites, designated sid, is similar to the yersiniabactin synthesis and uptake genes encoded on the Yersinia pestis high pathogenicity island. The siderophore biosynthetic genes in the sid operon contained a large deletion in the C. diphtheriae C7 strain, but the sid genes were unaffected in four clinical isolates that are representative of the dominant strains from the recent diphtheria epidemic in the former Soviet Union. Mutations in the siderophore biosynthetic genes in a clinical strain had no effect on siderophore synthesis or growth in low-iron conditions; however, a mutation in one of the putative transport proteins, cdtP, resulted in reduced growth in iron-depleted media, which suggests that this system may have a role in iron uptake. The findings from this study indicate that C. diphtheriae contains at least 18 DtxR binding sites and that DtxR may affect the expression of as many as 40 genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORYNEBACTERIUM diphtheriae
KW - SIDEROPHORES
KW - YERSINIA
N1 - Accession Number: 11641316; Kunkle, Carey A. 1 Schmitt, Michael P. 1; Email Address: schmitt@cber.fda.gov; Affiliation: 1: Laboratory of Bacterial Toxins, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland; Source Info: Dec2003, Vol. 185 Issue 23, p6826; Subject Term: CORYNEBACTERIUM diphtheriae; Subject Term: SIDEROPHORES; Subject Term: YERSINIA; Number of Pages: 15p; Illustrations: 6 Diagrams, 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Merkel, Tod J.
AU - Boucher, Philip E.
AU - Stibitz, Scott
AU - Grippe, Vanessa K.
T1 - Analysis of bvgR Expression in Bordetella pertusis.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2003/12//
VL - 185
IS - 23
M3 - Article
SP - 6902
EP - 6912
SN - 00219193
AB - Bordetella pertussis, the causative agent of whooping cough, produces a wide array of factors that are associated with its ability to cause disease. The expression and regulation of these virulence factors are dependent upon the bvg locus, which encodes three proteins: BvgA, a 23-kDa cytoplasmic protein; BvgS, a 135-kDa transmembrane protein; and BvgR, a 32-kDa protein. It is hypothesized that BvgS responds to environmental signals and interacts with BvgA, a transcriptional regulator, which upon modification by BvgS binds to specific promoters and activates transcription. An additional class of genes is repressed by the products of the bvg locus. The repression of these genes is dependent upon the third gene, bvgR. Expression of bvgR is dependent upon the function of BvgA and BvgS. This led to the hypothesis that the binding of phosphorylated BvgA to the bvgR promoter activates the expression of bvgR. We undertook an analysis of the transcriptional activation of bvgR expression. We identified the bvgR transcript by Northern blot analysis and identified the start site of transcription by primer extension. We determined that transcriptional activation of the bvgR promoter in an in vitro transcription system requires the addition of phosphorylated BvgA. Additionally, we have identified cis-acting regions that are required for BvgA activation of the bvgR promoter by in vitro footprinting and in vivo deletion and linker scanning analyses. A model of BvgA binding to the bvgR promoter is presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA pertussis
KW - WHOOPING cough
KW - VIRULENCE (Microbiology)
N1 - Accession Number: 11641323; Merkel, Tod J. 1; Email Address: merkel@cber.fda.gov Boucher, Philip E. 1 Stibitz, Scott 1 Grippe, Vanessa K. 1; Affiliation: 1: Center for Biologics Evaluation and Research Food and Drug Administration, Maryland; Source Info: Dec2003, Vol. 185 Issue 23, p6902; Subject Term: BORDETELLA pertussis; Subject Term: WHOOPING cough; Subject Term: VIRULENCE (Microbiology); Number of Pages: 11p; Illustrations: 2 Charts, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106740536
T1 - Recovery from heart failure with circulatory assist: a working group of the National, Heart, Lung, and Blood Institute.
AU - Reinlib L
AU - Abraham W
Y1 - 2003/12//2003 Dec
N1 - Accession Number: 106740536. Language: English. Entry Date: 20040528. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442138.
KW - Heart Assist Devices
KW - Heart Failure -- Therapy
KW - Biological Markers
KW - Clinical Trials
KW - Databases
KW - Heart Failure -- Physiopathology
KW - Program Development
KW - Program Evaluation
KW - United States
SP - 459
EP - 463
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
JA - J CARD FAIL
VL - 9
IS - 6
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - BACKGROUND: Over the past decade, mechanical circulatory support has been beneficial as a bridge to cardiac transplantation, and anecdotal evidence suggests that heart failure patients fitted with mechanical assist devices experience direct cardiac benefits. Moreover, recent trials on limited numbers and subpopulations of patients--notably the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH)--support earlier observations of improved cardiac function and point towards the use of assist devices as destination therapy.Methods and results To investigate this phenomenon, on August 2-3, 2001, the National Heart, Lung, and Blood Institute convened the working group, 'Recovery from Heart Failure with Circulatory Assist' in Bethesda, Maryland. The team included cardiac surgeons, cardiologists, and experts in experimental research. The goal was to prioritize recommendations to guide future programs in: (1). elucidating the mechanisms leading to reverse remodeling associated with a left ventricular assist device (LVAD); (2). exploring advanced treatments, including novel pharmacologies, tissue engineering, and cell therapies, to optimize recovery with LVAD therapy; and (3). identifying target genes, proteins, and cellular pathways to focus on for production of novel therapies for myocardial recovery and cardiovascular disease. CONCLUSIONS: The working group also made research and clinical recommendations to eventually translate findings into improved therapeutic strategies and device design: (1). support collaborations among clinical and basic scientists with an emphasis on clinical/translational research that might eventually lead to clinical trials; (2). identify candidate patients most likely to benefit from LVAD as a destination therapy; (3). explore potential biomarkers indicating when patients could most successfully be weaned from devices; and (4). promote clinical and experimental study of mechanically assisted organs and the tissue derived from them.
SN - 1071-9164
AD - Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland
U2 - PMID: 14966786.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Megivern, Deborah M.
T1 - THE MENTAL HEALTH DESK REFERENCE (Book).
JO - Journal of College Student Psychotherapy
JF - Journal of College Student Psychotherapy
Y1 - 2003/12//
VL - 18
IS - 2
M3 - Book Review
SP - 83
EP - 85
SN - 87568225
AB - Reviews the book "The Mental Health Desk Reference," by Elizabeth Welfel and R. Elliott Ingersoll.
KW - MENTAL health
KW - WELFEL, Elizabeth
KW - INGERSOLL, R.
KW - MENTAL Health Desk Reference, The (Book)
N1 - Accession Number: 12588259; Megivern, Deborah M. 1; Affiliation: 1: Washington University Center for Mental Health Services Research, MO; Source Info: 2003, Vol. 18 Issue 2, p83; Subject Term: MENTAL health; Reviews & Products: MENTAL Health Desk Reference, The (Book); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); People: WELFEL, Elizabeth; People: INGERSOLL, R.; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106626980
T1 - Effect of room illuminance on monitor black level luminance and monitor calibration.
AU - Chakrabarti K
AU - Kaczmarek RV
AU - Thomas JA
AU - Romanyukha A
Y1 - 2003/12//
N1 - Accession Number: 106626980. Language: English. Entry Date: 20050506. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Computer/Information Science; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9100529.
KW - Light
KW - Radiographic Image Enhancement
KW - Picture Archiving and Communication Systems
KW - Work Environment
KW - Data Display
KW - Visual Perception
KW - Phantoms, Imaging
KW - Evaluation Research
KW - Human
SP - 350
EP - 355
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
JA - J DIGIT IMAGING
VL - 16
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - In this article we demonstrate the effect of room illuminance and surrounding monitor black level luminance on image quality for soft copy interpretation. Luminance values of a 10% central target and image quality evaluations and observer performance using a contrast-detail mammography (CDMAM) phantom demonstrate these effects. Our results indicate that high room illuminance has a more damaging effect on image quality when the surrounding monitor luminance is 0% to 5% of the maximum monitor luminance. The effect of room illuminance is less obvious when the surrounding monitor luminance is 20% of the maximum.
SN - 0897-1889
AD - Radiological Devices Branch, DRARD/ODE/CDRH, HFZ-470, Food and Drug Administration, 9200 Corporate Blvd., Rockville, MD 20850; KXC@CDRH.FDA.GOV
U2 - PMID: 14747935.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lamont, William H.
T1 - Concentration of inorganic arsenic in samples of white rice from the United States
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2003/12//
VL - 16
IS - 6
M3 - Article
SP - 687
SN - 08891575
AB - Concentrations of inorganic arsenic were determined by ion-trap, electrospray, mass spectrometry in 40 samples of white rice, which were collected in the United States. Inorganic arsenic was qualitatively present in all samples. The quantitative range of concentrations of inorganic arsenic extended from <0.025 to 0.271 μg/g (wet-mass basis). The extremes of the range were validated with acceptable analytical recoveries of fortifications. Statistical bounds of the range were established and assessed. The distribution of concentrations over the observed range was characterized statistically with an empirical lognormal probability distribution function. For the samples of white rice, a geometric mean corresponding to 0.112 μg/g and a geometric standard deviation equivalent to 0.055 μg/g of inorganic arsenic were derived from the empirical lognormal function. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARSENIC
KW - MASS spectrometry
KW - STANDARD deviations
KW - Inorganic arsenic
KW - White rice
N1 - Accession Number: 11253843; Lamont, William H. 1; Email Address: william.lamont@cfsan.fda.gov; Affiliation: 1: Food and Drug Administration, Office of Plant and Dairy Foods and Beverages, Elemental Research Branch, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Dec2003, Vol. 16 Issue 6, p687; Subject Term: ARSENIC; Subject Term: MASS spectrometry; Subject Term: STANDARD deviations; Author-Supplied Keyword: Inorganic arsenic; Author-Supplied Keyword: White rice; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0889-1575(03)00097-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Senkel Jr., Arthur
AU - Jolbitado, Beverly
AU - Yifan Zhang
AU - White, David G.
AU - Ayers, Sherry
AU - Jianghong Meng
T1 - Isolation and Characterization of Escherichia coli Recovered from Maryland Apple Cider and the Cider Production Environment.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/12//
VL - 66
IS - 12
M3 - Article
SP - 2237
EP - 2244
SN - 0362028X
AB - Contaminated apple cider has been implicated in several Escherichia coli O157:H7 outbreaks. In an attempt to investigate sources and modes of entry of E. coli into apple cider, samples of fresh apple, pomace, and cider and equipment and mill floor swabs were analyzed for standard plate counts (SPC), total coliforms (TC), fecal coliforms (FC), and E. coli. E. coli was isolated from 14 (33%) of 42 samples of bottled fresh cider, from food equipment in 6 (67%) of 9 mills, and from apples, pomace, or cider in 7 (78%) of 9 mills. Seventy-five E. coli isolates were further characterized for Shiga toxin-producing E. coli (STEC)-associated virulence factors, antimicrobial susceptibility, and pulsed-field gel electrophoresis (PFGE) type. No E. coli O157:H7 or other STEC was identified. Serotyping and PFGE revealed 64 distinct profiles, suggesting that recovered E. coli arose from multiple independent sources. However, on one occasion, E. coli isolated from the source apple sample was closely related to the E. coli identified in the finished cider sample. E. coli isolates were further tested for antimicrobial susceptibility to 17 antimicrobial agents of human and veterinary importance. Fourteen (19%) of the 75 isolates were resistant to at least one of the antimicrobial agents tested, and 9 (12%) were resistant to at least two of these agents. Of the resistant isolates recovered, 64% were resistant to tetracycline and 57% were resistant to streptomycin. Overall, the level of E. coli contamination in source apple samples did not differ significantly from those in samples of pomace, cider at the press, and cider entering the bottling tank; therefore, source apples cannot be dismissed as a potential contributor of E. coli to the cider-making process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Toxins
KW - Cider (Alcoholic beverage)
N1 - Accession Number: 11856253; Senkel Jr., Arthur 1; Jolbitado, Beverly 2; Yifan Zhang 3; White, David G. 4; Ayers, Sherry 4; Jianghong Meng 3; Email Address: jm332@umail.umd.edu; Affiliations: 1: Division of Food Control, Maryland Department of Health and Mental Hygiene; 2: Division of Public Health Environmental Microbiology, Maryland Department of Health and Mental Hygiene; 3: Department of Nutrition and Food Science, University of Maryland, College Park; 4: Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration; Issue Info: Dec2003, Vol. 66 Issue 12, p2237; Thesaurus Term: Escherichia coli; Thesaurus Term: Toxins; Subject Term: Cider (Alcoholic beverage); Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cook, David W.
T1 - Sensitivity of Vibrio Species in Phosphate-Buffered Saline and in Oysters to High-Pressure Processing.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2003/12//
VL - 66
IS - 12
M3 - Article
SP - 2276
EP - 2282
SN - 0362028X
AB - Multiple strains of Vibrio vulnificus, Vibrio parahaemolyticus, and Vibrio cholerae non-O1 were tested in phosphate-buffered saline for their sensitivity to high-pressure processing (HPP). Variability in sensitivity among strains was observed for all species; this variability decreased at higher pressures. V. vulnificus was the species that was most sensitive to treatment at 200 MPa (decimal reduction time [D] = 26 s), and V. cholerae was the species that was most resistant to treatment at 200 MPa (D = 149 s). The O3:K6 serotype of V. parahaemolyticus was more resistant to pressure than other serotypes of V. parahaemolyticus were. The results of studies involving V. vulnificus naturally occurring in oysters revealed that a pressure treatment of 250 MPa for 120 s achieved a >5-log reduction in the levels of this bacterium. V. parahaemolyticus serotype O3:K6 in oysters required a pressure of 300 MPa for 180 s for a comparable 5-log reduction. When properly applied, HPP can be effective in improving the safety of shellfish with respect to Vibrio spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food industry
KW - Cooking (Oysters)
KW - Vibrio vulnificus
KW - Vibrio cholerae
N1 - Accession Number: 11856258; Cook, David W. 1; Email Address: docjoc@cableone.net; Affiliations: 1: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama; Issue Info: Dec2003, Vol. 66 Issue 12, p2276; Thesaurus Term: Food industry; Subject Term: Cooking (Oysters); Subject Term: Vibrio vulnificus; Subject Term: Vibrio cholerae; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schmechel, D.
AU - Górny, R.L.
AU - Simpson, J.P.
AU - Reponen, T.
AU - Grinshpun, S.A.
AU - Lewis, D.M.
T1 - Limitations of monoclonal antibodies for monitoring of fungal aerosols using Penicillium brevicompactum as a model fungus
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2003/12//
VL - 283
IS - 1/2
M3 - Article
SP - 235
SN - 00221759
AB - Molds are ubiquitous in every environment and many species have been recently associated with an increase in opportunistic infections in immunocompromised patients or the exacerbation of asthmatic episodes in allergic patients. The degree of environmental contamination with fungi thus needs to be monitored and in this study we report the development of a monoclonal antibody (mAb)-mediated enzyme-linked immunosorbent assay (ELISA) for the detection of spores of Penicillium brevicompactum in experimental model aerosols. In addition, we have investigated the influence of different parameters of air sampling and sample recovery on ELISA performance.MAbs were produced with standard hybridoma techniques and cross-reactivities were determined against spores of 53 fungal species by indirect ELISA. Standardized experimental fungal aerosols were collected with the Button Personal Inhalable Aerosol Sampler® onto polycarbonate or polytetrafluoroethylene filters (PTFE) and the effects of different extraction buffers and filter agitation methods during sample processing on spore recovery and ELISA detection were investigated.Five mAbs were produced and all of them cross-reacted with several of 31 related Aspergillus, Penicillium and Eurotium species. However, cross-reactivities with 21 non-related fungi were rare.Spores were recovered in much higher numbers from polycarbonate filters (PFs) than from polytetrafluoroethylene filters. Optical densities (ODs) in ELISA were higher for spores collected into carbonate coating buffer (CCB) than phosphate-buffered saline (PBS). Filter bath sonication following filter vortexing had no positive effects on ELISA sensitivity.The cross-reactivity patterns of mAbs suggest that Aspergillus and Penicillium species share multiple antigens. Quantitative ELISA results for fungal aerosols were found to be influenced by differential sample processing and thus method standardization will be essential to maintain the comparability of immunometric monitoring results. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFECTION
KW - ALLERGY
KW - PATIENTS
KW - IMMUNOGLOBULINS
KW - Antibody cross-reactivity
KW - Button personal inhalable aerosol sampler
KW - carbonate coating buffer (CCB)
KW - ELISA
KW - enzyme-linked immunosorbent assay (ELISA)
KW - Fungal aerosol
KW - monoclonal antibody (mAb)
KW - optical density (OD)
KW - Penicillium brevicompactum
KW - phosphate-buffered saline (PBS)
KW - polycarbonate filter (PF)
KW - polytetrafluoroethylene (PTFE)
KW - room temperature (RT)
KW - Sample processing
KW - substrate incubation time (SIT)
N1 - Accession Number: 11537458; Schmechel, D. 1; Email Address: dschmechel@cdc.gov Górny, R.L. 2 Simpson, J.P. 1 Reponen, T. 3 Grinshpun, S.A. 3 Lewis, D.M. 1; Affiliation: 1: Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S H-4218, Morgantown, WV 26505, USA 2: Department of Biohazards, Institute of Occupational Medicine and Environmental Health, 13 Kościelna Street, 41-200 Sosnowiec, Poland 3: Center for Health-Related Aerosol Studies, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA; Source Info: Dec2003, Vol. 283 Issue 1/2, p235; Subject Term: INFECTION; Subject Term: ALLERGY; Subject Term: PATIENTS; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: Antibody cross-reactivity; Author-Supplied Keyword: Button personal inhalable aerosol sampler; Author-Supplied Keyword: carbonate coating buffer (CCB); Author-Supplied Keyword: ELISA; Author-Supplied Keyword: enzyme-linked immunosorbent assay (ELISA); Author-Supplied Keyword: Fungal aerosol; Author-Supplied Keyword: monoclonal antibody (mAb); Author-Supplied Keyword: optical density (OD); Author-Supplied Keyword: Penicillium brevicompactum; Author-Supplied Keyword: phosphate-buffered saline (PBS); Author-Supplied Keyword: polycarbonate filter (PF); Author-Supplied Keyword: polytetrafluoroethylene (PTFE); Author-Supplied Keyword: room temperature (RT); Author-Supplied Keyword: Sample processing; Author-Supplied Keyword: substrate incubation time (SIT); Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jim.2003.09.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whittaker, P.
AU - Mossoba, M.M.
AU - Al-Khaldi, S.
AU - Fry, F.S.
AU - Dunkel, V.C.
AU - Tall, B.D.
AU - Yurawecz, M.P.
T1 - Identification of foodborne bacteria by infrared spectroscopy using cellular fatty acid methyl esters
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2003/12//
VL - 55
IS - 3
M3 - Article
SP - 709
SN - 01677012
AB - Identification of bacterial species by profiling fatty acid methyl esters (FAMEs) has commonly been carried out by using a 20-min capillary gas chromatographic procedure followed by library matching of FAME profiles using commercial MIDI databases and proprietary pattern recognition software. Fast GC (5 min) FAME procedures and mass spectrometric methodologies that require no lipid separation have also been reported. In this study, bacterial identification based on the rapid (2 min) infrared measurement of FAME mixtures was demonstrated. The microorganisms investigated included Gram positive bacteria Staphylococcus aureus, Listeria monocytogenes, Bacillus anthracis, and Bacillus cereus, and Gram negative bacteria from the family Enterobacteriacae: Yersinia enterocolitica, Salmonella typhimurium, Shigella sonnei, and Escherichia coli (four strains of E. coli), and non-Enterobacteriacae: Vibrio cholerae, Vibrio vulnificus, and Vibrio parahemolyticus. Foodborne bacterial mixtures of FAMEs were measured by using an attenuated total reflection (ATR)–Fourier transform infrared (FTIR) spectroscopic procedure and discriminated by multivariate analysis. Results showed that the Enterobacteriacae could be discriminated from the vibrios. The identification was at the level of species (for the Bacillus and Vibrio genera) or strains (for the E. coli species). A series of bacterial FAME test samples were prepared and analyzed for accuracy of identification, and all were correctly identified. Our results suggest that this infrared strategy could be used to identify foodborne pathogens. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIA
KW - CHROMATOGRAPHIC analysis
KW - PATTERN perception
KW - BACILLUS cereus
KW - Bacteria
KW - Infrared
KW - Principal component analysis (PCA)
KW - Soft independent modeling of class analogy (SIMCA)
N1 - Accession Number: 11252567; Whittaker, P. 1 Mossoba, M.M. 2; Email Address: mmossoba@cfsan.fda.gov Al-Khaldi, S. 3 Fry, F.S. 2 Dunkel, V.C. 4 Tall, B.D. 3 Yurawecz, M.P. 1; Affiliation: 1: Division of Research and Applied Technology, ONPLDS, Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 2: Division of General Scientific Support, OSAS, Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), 5100 Paint Branch Parkway, Mail Stop HFS 717, Room BE-012, College Park, MD 20740-3835, USA 3: Division of Microbiological Studies, OPDFB, Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 4: Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), OSCI, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Dec2003, Vol. 55 Issue 3, p709; Subject Term: BACTERIA; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PATTERN perception; Subject Term: BACILLUS cereus; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Infrared; Author-Supplied Keyword: Principal component analysis (PCA); Author-Supplied Keyword: Soft independent modeling of class analogy (SIMCA); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mimet.2003.07.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Christie, Stephen
AU - Fone, David
T1 - Equity of access to tertiary hospitals in Wales: a travel time analysis.
JO - Journal of Public Health Medicine
JF - Journal of Public Health Medicine
Y1 - 2003/12//
VL - 25
IS - 4
M3 - Article
SP - 344
EP - 350
SN - 09574832
AB - Background The objective of the study was to investigate the implications for equity of geographical access for population subgroups arising from hypothetical scenarios of change in configuration of National Health Service tertiary hospital service provision located in Wales. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Public Health Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EQUITY
KW - HOSPITALS
KW - RESIDENTS
KW - RURAL geography
KW - TRAVEL time (Traffic engineering)
KW - WALES. National Health Service
KW - WALES
KW - equity
KW - geographical access
KW - travel time
N1 - Accession Number: 44380291; Christie, Stephen 1; Email Address: stephen.christie@nphs.wales.nhs.uk Fone, David 2,3; Affiliation: 1: Research Officer, National Public Health Service for Wales, Mamhilad Park Estate, Pontypool NP4 0YP 2: Consultant, National Public Health Service for Wales, Mamhilad Park Estate, Pontypool NP4 0YP 3: Honorary Senior Lecturer in Public Health Medicine, Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff CF14 4XN; Source Info: Dec2003, Vol. 25 Issue 4, p344; Subject Term: EQUITY; Subject Term: HOSPITALS; Subject Term: RESIDENTS; Subject Term: RURAL geography; Subject Term: TRAVEL time (Traffic engineering); Subject Term: WALES. National Health Service; Subject Term: WALES; Author-Supplied Keyword: equity; Author-Supplied Keyword: geographical access; Author-Supplied Keyword: travel time; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 7p; Document Type: Article
L3 - 10.1093/pubmed/fdg090
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106777969
T1 - Equity of access to tertiary hospitals in Wales: a travel time analysis.
AU - Christie S
AU - Fone D
Y1 - 2003/12//
N1 - Accession Number: 106777969. Language: English. Entry Date: 20040917. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9011205.
KW - Health Facility Planning -- Methods
KW - Health Services Accessibility -- Wales
KW - Hospitals
KW - Time Factors
KW - Travel
KW - Aged
KW - Catchment Area (Health)
KW - Comparative Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Health Services Accessibility -- Economics
KW - National Health Programs -- Administration
KW - National Health Programs -- Economics
KW - National Health Programs -- Wales
KW - Needs Assessment
KW - Rural Areas
KW - Rural Health Services
KW - Sensitivity and Specificity
KW - Wales
KW - Human
SP - 344
EP - 350
JO - Journal of Public Health Medicine
JF - Journal of Public Health Medicine
JA - J PUBLIC HEALTH MED
VL - 25
IS - 4
PB - Oxford University Press / USA
AB - BACKGROUND: The objective of the study was to investigate the implications for equity of geographical access for population subgroups arising from hypothetical scenarios of change in configuration of National Health Service tertiary hospital service provision located in Wales. METHODS: For each of three scenarios, the status quo and centralization of services to one of two locations, we used a travel time road length matrix in geographical information software to calculate the proportion of the population living within 30, 60, 90 and 120 min travel of each hospital site and the associated mean, median and 90th percentile travel times. We analysed data for the total resident population of Wales, for residents aged 75 or more years, for residents of the most deprived 10 per cent of enumeration districts, and for residents of rural areas. RESULTS: Centralization of services reduces geographical access for all population subgroups. Access varies between population subgroups, both between and within different scenarios of service configuration. A change in service configuration may improve access for one subgroup but reduce access for another. The interpretation may also vary according to whether the defined cut point for comparing access is based on short or long travel times. Measurements of absolute and relative access are sensitive to the assumed travel speeds. CONCLUSION: Access for the total population does not imply equity of access for subgroups of the population. Comparisons of access between scenarios are dependent on which measure of access is the indicator of choice. Results are sensitive to the road network travel speeds and further local validation may be necessary. This method can provide explicit information to health service planners on the effects on equity of access from a change in service configuration.
SN - 0957-4832
AD - Research Officer, National Public Health Service for Wales, Mamhilad Park Estate, Pontypool NP4 0YP; stephen.christie@nphs.wales.nhs.uk
U2 - PMID: 14747594.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Li, Linge
AU - Chiarelli, M. Paul
AU - Branco, Paula S.
AU - Antunes, Alexandra M.
AU - Marques, M. Matilde
AU - Gonçalves, Luísa L.
AU - Beland, Frederick A.
T1 - Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadrupole ion trap mass spectrometry
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2003/12//
VL - 14
IS - 12
M3 - Article
SP - 1488
SN - 10440305
AB - Product ion spectra from thirteen C8-substituted alkylaniline adducts of guanine and deoxyguanosine were generated using electrospray ionization and quadrupole ion trap mass spectrometry and studied to investigate the possibility of differentiating isomeric adduct structures based upon the relative abundances of fragment ions derived from the alkylaniline-modified guanine bases (BH2+ ions). The structural discrimination of the BH2+ ions formed by attachment of isomeric alkylanilines to the C8 position of guanine is a challenging problem because the ions tend to yield product ion spectra that are qualitatively identical upon collisional activation. In this study, a statistical method, referred to as a similarity index, was used to compare the product ion spectra of isomeric BH2+ ions and differentiate their structures. All the adducts investigated could be distinguished from SIs calculated using 5–6 product ions. These results suggest that a searchable database of product ion spectra may be created and used to characterize DNA adducts from aromatic amines whenever they are detected at levels amenable to mass spectral analysis. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IONS
KW - MASS spectrometry
KW - IONIZATION (Atomic physics)
KW - DNA
N1 - Accession Number: 11537281; Li, Linge 1 Chiarelli, M. Paul 1; Email Address: mchiare@luc.edu Branco, Paula S. 2 Antunes, Alexandra M. 2 Marques, M. Matilde 3 Gonçalves, Luísa L. 3 Beland, Frederick A. 4; Affiliation: 1: Department of Chemistry, Loyola University, Chicago, Illinois, USA 2: Departamento de Química, Centro de Química Fina e Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal 3: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Lisboa, Portugal 4: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Dec2003, Vol. 14 Issue 12, p1488; Subject Term: IONS; Subject Term: MASS spectrometry; Subject Term: IONIZATION (Atomic physics); Subject Term: DNA; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jasms.2003.08.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106757183
T1 - Clinician influence in medical device development.
AU - Scott W
Y1 - 2003///2003 Winter
N1 - Accession Number: 106757183. Language: English. Entry Date: 20040716. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101234977.
KW - Consumer Participation
KW - Equipment Design
KW - Health Personnel
KW - United States
SP - 51
EP - 51
JO - Journal of the Association for Vascular Access
JF - Journal of the Association for Vascular Access
JA - J ASSOC VASC ACCESS
VL - 8
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1552-8855
AD - Director, Health Promotion Officer -- FDA Center for Devices and Radiological Health, Office of Health and Industry Programs, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shaikh, B.
AU - Rummel, N.
AU - Gieseker, C.
AU - Serfling, S.
AU - Reimschuessel, R.
T1 - DRUG METABOLISM, PHARMACOKINETICS AND TOXICOLOGY Metabolism and residue depletion of albendazole and its metabolites in rainbow trout, tilapia and Atlantic salmon after oral administration.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2003/12//
VL - 26
IS - 6
M3 - Article
SP - 421
EP - 427
PB - Wiley-Blackwell
SN - 01407783
AB - Shaikh, B., Rummel, N., Gieseker, C., Serfling, S., Reimschuessel, R. Metabolism and residue depletion of albendazole and its metabolites in rainbow trout, tilapia and Atlantic salmon after oral administration. J. vet. Pharmacol. Therap. 26, 421–427. Metabolic and residue depletion profiles of albendazole (ABZ) and its major metabolites in three fish species, rainbow trout, tilapia and Atlantic salmon are reported. Based on these profiles, similarities (or dissimilarities) between species will determine the potential to group fish species. ABZ at 10 mg/kg body weight was incorporated into fish food formulated in a gelatin base or in gel capsule and fed as a single dose to six fish from each species. Rainbow trout were held three each in a partitioned 600-L tank. Tilapia and Atlantic salmon were housed in separate 20-L tanks. Samples of muscle with adhering skin were collected at 8, 12, 18, 24, 48, 72, and 96 h postdose from trout kept at 12 °C, at 4, 8, 12, 24, 48, 72, 96, 120, and 144 h postdose from tilapia kept at 25 °C and at 8, 14, 24, 48, 72, and 96 h postdose from Atlantic salmon kept at 15 °C. The samples were homogenized in dry ice and subjected to extraction and cleanup procedures. The final extracts were analyzed for parent drug ABZ and its major metabolites, albendazole sulfoxide (ABZ-SO), albendazole sulfone (ABZ-SO2) and albendazole aminosulfone using high-performance liquid chromatography with fluorescence detection. ABZ was depleted by 24 h in trout and tilapia and by 48 h in salmon; ABZ-SO, a pharmacologically active metabolite, was depleted by 48 h in tilapia, by 72 h in rainbow trout and was present until 96 h in salmon; and low levels of ABZ-SO2 and albendazole aminosulfone, both inactive metabolites, were detectable at least till 96 h in all three fish species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBENDAZOLE
KW - METABOLITES
KW - METABOLISM
KW - RAINBOW trout
KW - TILAPIA
KW - SALMON
N1 - Accession Number: 11762591; Shaikh, B. 1; Email Address: bshaikh@cvm.fda.gov Rummel, N. 1 Gieseker, C. 1 Serfling, S. 1 Reimschuessel, R. 1; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD, USA; Source Info: Dec2003, Vol. 26 Issue 6, p421; Subject Term: ALBENDAZOLE; Subject Term: METABOLITES; Subject Term: METABOLISM; Subject Term: RAINBOW trout; Subject Term: TILAPIA; Subject Term: SALMON; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 7p; Document Type: Article
L3 - 10.1046/j.0140-7783.2003.00534.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Korotkova, Ekaterina A.
AU - Park, Renee
AU - Cherkasova, Elena A.
AU - Lipskaya, Galina Y.
AU - Chumakov, Konstantin M.
AU - Feldman, Esfir V.
AU - Kew, Olen M.
AU - Agol, Vadim I.
T1 - Retrospective Analysis of a Local Cessation of Vaccination against Poliomyelitis: a Possible Scenario for the Future.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003/12//
VL - 77
IS - 23
M3 - Article
SP - 12460
EP - 12465
SN - 0022538X
AB - The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circulation. We describe here a retrospective analysis of the cessation of OPV usage in a region of the Byelorussian Republic of the former Soviet Union in 1963 to 1966. During this period, a widespread circulation and evolution of independent lineages of vaccine-derived polioviruses took place in the region. Some of these lineages appeared to originate from OPV given to 40 children in the community during this period of essentially no vaccinations. The data demonstrate very high risks associated with both the local cessation of OPV vaccination and the proposed use of OPV to control a possible reemergence of poliovirus in the postvaccination period. The high transmissibility of OPV-derived viruses in nonimmune population, documented here, and the known existence of long-term OPV excretors should be also considered in assessing risks of the synchronized global cessation of OPV usage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIO
KW - VACCINATION
KW - IMMUNIZATION
KW - IMMUNOTHERAPY
N1 - Accession Number: 11645696; Korotkova, Ekaterina A. 1 Park, Renee 2 Cherkasova, Elena A. 1,3 Lipskaya, Galina Y. 1,4 Chumakov, Konstantin M. 3 Feldman, Esfir V. 5 Kew, Olen M. 2 Agol, Vadim I. 1,6; Email Address: agol@belozersky.msu.ru; Affiliation: 1: A.N. Bolzersky Institute of Physical-Chemical Biology, Moscow State University 2: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Georgia 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville 4: European Regional Office of the World Health Organization, Denmark 5: Research Institute for Epidemiology and Microbiology, Belarus 6: M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow; Source Info: Dec2003, Vol. 77 Issue 23, p12460; Subject Term: POLIO; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: IMMUNOTHERAPY; Number of Pages: 6p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yoshitomi, Ken J.
AU - Jinneman, Karen C.
AU - Weagant, Stephen D.
T1 - Optimization of a 3′-minor groove binder-DNA probe targeting the uidA gene for rapid identification of Escherichia coli O157:H7 using real-time PCR
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2003/12//
VL - 17
IS - 6
M3 - Article
SP - 275
SN - 08908508
AB - Enterohemorrhagic Escherichia coli are harmful human pathogens capable of causing bloody diarrhea and vomiting. An important serotype commonly associated with human illness is the E. coli O157:H7 serotype. Unlike other real-time polymerase chain reaction (PCR) methods for identifying E. coli O157:H7, this study describes the development and optimization of a real-time PCR method targeting a conserved point mutation at +93 in the uidA (gusA) gene that is unique to O157:H7, distinguishing it from non-O157:H7 serotypes. A TET-labeled Minor Groove Binder (MGB) DNA probe was designed for use in a 5′ nuclease PCR assay. Using a panel of two E. coli O157:H7 strains, three E. coli non-O157:H7 strains, and one non-E. coli species, the assay was optimized for the specific detection of the E. coli O157:H7 strains. Optimal conditions were identified at high anneal/extend temperatures, low magnesium concentrations, and low probe concentrations, resulting in correct identification of E. coli O157:H7 and non-O157:H7 strains. The improved specificity of MGB probes for single base pair mismatches such as the +93 uidA mutation provides a novel approach towards rapid identification of E. coli O157:H7. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - PATHOGENIC microorganisms
KW - DIARRHEA
KW - VOMITING
KW - POLYMERASE chain reaction
KW - Escherichia coli O157:H7
KW - Minor groove binder probe
KW - uidA
N1 - Accession Number: 11253912; Yoshitomi, Ken J. 1,2; Email Address: ken.yoshitomi@fda.gov Jinneman, Karen C. 1,2 Weagant, Stephen D. 2; Affiliation: 1: Seafood Products Research Center, US Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021-4421, USA 2: Pacific Regional Laboratory Northwest, US Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021-4421, USA; Source Info: Dec2003, Vol. 17 Issue 6, p275; Subject Term: ESCHERICHIA coli; Subject Term: PATHOGENIC microorganisms; Subject Term: DIARRHEA; Subject Term: VOMITING; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Escherichia coli O157:H7; Author-Supplied Keyword: Minor groove binder probe; Author-Supplied Keyword: uidA; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.mcp.2003.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nawaz, Mohamed S.
AU - Wang, Rong-Fu
AU - Khan, Saeed A.
AU - Khan, Ashraf A.
T1 - Detection of galE gene by polymerase chain reaction in campylobacters associated with Guillain–Barre syndrome
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2003/12//
VL - 17
IS - 6
M3 - Article
SP - 313
SN - 08908508
AB - Guillain–Barre Syndrome (GBS) is a neuromuscular disorder and campylobacteriosis is known to trigger the onset of the disorder. A polymerase chain reaction (PCR) protocol was developed that could specifically amplify a 497-bp region of the UDP-galactose 4-epimerase (galE) gene sequence in campylobacters responsible for triggering the onset of GBS. The identity of the PCR product was confirmed by HindIII endonuclease restriction digestion, which produced the predicted 430 and 67-bp DNA fragments. The assay could detect the presence of the gene in Campylobacter suspensions containing as few as 5 cells ml−1. The assay detected the presence of the gene in 17 of the 20 campylobacters isolated from chicken, 9 of the 13 campylobacters isolated from turkey and 7 of the 7 campylobacters isolated from human stools. All Campylobacter strains isolated from chicken, turkey and clinical samples were resistant to multiple antibiotics. The assay failed to detect the presence of the gene in five different microaerophilic strains of Helicobacter spp., E. coli and Salmonella spp. The entire diagnostic assay, including template preparation, amplification and electrophoresis, can be completed within 6 h. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GUILLAIN-Barre syndrome
KW - CAMPYLOBACTER infections
KW - POLYMERASE chain reaction
KW - GALACTOSE
KW - ELECTROPHORESIS
KW - galE gene
KW - Guillain–Barre Syndrome
KW - Polymerase chain reaction
N1 - Accession Number: 11253918; Nawaz, Mohamed S.; Email Address: mnawaz@nctr.fda.gov Wang, Rong-Fu 1 Khan, Saeed A. 1 Khan, Ashraf A. 1; Affiliation: 1: Department of Microbiology, Food and Drug Administration, The National Center for Toxicological Research, Jefferson AR 72079, Argentina; Source Info: Dec2003, Vol. 17 Issue 6, p313; Subject Term: GUILLAIN-Barre syndrome; Subject Term: CAMPYLOBACTER infections; Subject Term: POLYMERASE chain reaction; Subject Term: GALACTOSE; Subject Term: ELECTROPHORESIS; Author-Supplied Keyword: galE gene; Author-Supplied Keyword: Guillain–Barre Syndrome; Author-Supplied Keyword: Polymerase chain reaction; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.mcp.2003.08.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - LoPachin, Richard M.
AU - Jones, Richard C.
AU - Patterson, Tucker A.
AU - Slikker Jr., William
AU - Barber, David S.
T1 - Application of Proteomics to the Study of Molecular Mechanisms in Neurotoxicology
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2003/12//
VL - 24
IS - 6
M3 - Article
SP - 761
SN - 0161813X
AB - The proteome is the protein compliment of the genome and is the result of genetic expression, ribosomal synthesis and proteolytic degradation. Proteins participate in most major cell processes and their function is highly regulated by post-translational modifications such as phosphorylation and glycosylation. As a result, neurotoxicant-induced changes in protein levels, function or regulation could have a negative impact on neuronal viability. At the molecular level, direct oxidative or covalent modifications of individual proteins by various chemicals or drugs is likely to lead to perturbation of tertiary structure and a loss of function. The proteome and the functional determinants of its individual protein components are, therefore, likely targets of neurotoxicant action and resulting characteristic disruptions could be critically involved in corresponding mechanisms of neurotoxicity. Clearly, investigating changes in the proteome can provide important clues for deciphering mechanisms of toxicant action and, therefore, proteomics, the study of the proteome, is currently, and will likely remain, a significant experimental approach for mechanistic research in neurotoxicology. The purpose of this review is to discuss proteomics as a tool for neurotoxicological investigations. A variety of classic proteomic techniques (e.g. liquid chromatography (LC)/tandem mass spectroscopy, two-dimensional gel image analysis) as well as more recently developed approaches (e.g. two-hybrid systems, antibody arrays, protein chips, isotope-coded affinity tags, ICAT) are available to determine protein levels, identify components of multiprotein complexes and to detect post-translational changes. Proteomics, therefore, offers a comprehensive overview of cell proteins, and in the case of neurotoxicant exposure, can provide quantitative data regarding changes in corresponding expression levels and/or post-translational modifications that might be associated with neuron injury. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - PROTEINS
KW - GENOMES
KW - GENE expression
KW - NEUROTOXIC agents
KW - Mass spectroscopy
KW - Neurotoxicant
KW - Protein adduction
KW - Proteome
N1 - Accession Number: 11464571; LoPachin, Richard M. 1; Email Address: lopachin@aecom.yu.edu Jones, Richard C. 2 Patterson, Tucker A. 3 Slikker Jr., William 3 Barber, David S. 4; Affiliation: 1: Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Moses 7, 111 E, 210th St., Bronx, NY 10467, USA 2: Division of Chemistry, National Center for Toxicological Research/FDA, Jefferson, AR, USA 3: Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA 4: Center for Environmental & Human Toxicology, University of Florida, Gainesville, FL, USA; Source Info: Dec2003, Vol. 24 Issue 6, p761; Subject Term: PROTEOMICS; Subject Term: PROTEINS; Subject Term: GENOMES; Subject Term: GENE expression; Subject Term: NEUROTOXIC agents; Author-Supplied Keyword: Mass spectroscopy; Author-Supplied Keyword: Neurotoxicant; Author-Supplied Keyword: Protein adduction; Author-Supplied Keyword: Proteome; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.neuro.2003.08.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Jonathan E.
AU - Thompson, Mary Lou
AU - Naik, Inakshi
AU - Theodorou, Penny
AU - Esswein, Eric
AU - Tassell, Halina
AU - Daya, Aarti
AU - Renton, Kevin
AU - Spies, Adri
AU - Paicker, Janice
AU - Young, Taryn
AU - Jeebhay, Mohamed
AU - Ramushu, Suzan
AU - London, Leslie
AU - Rees, David J.
T1 - The Utility of Biological Monitoring for Manganese in Ferroalloy Smelter Workers in South Africa
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2003/12//
VL - 24
IS - 6
M3 - Article
SP - 875
SN - 0161813X
AB - Five hundred and nine workers at a manganese (Mn) smelting works comprising eight production facilities and 67 external controls were studied cross-sectionally. Exposure measures from personal sampling included inhalable dust, cumulative exposure indices (CEI) and average intensity (INT = CEI/years exposed) calculated for the current job at the smelter and also across all jobs held by subjects. Biological exposure was measured by Mn in the blood (MnB) and urine (MnU) and biological effect was measured by serum prolactin. Average lifetime exposure intensity across all jobs ranged from near 0 (0.06 μg/m3) for unexposed external referents to 5 mg/m3. Atmospheric exposures and MnB and MnU distributions were consistent with published data for both unexposed and smelter workers. Associations between biological exposures and groups defined by atmospheric exposures in the current job were substantial for MnB, less so for MnU and absent for serum prolactin. Random sampling of MnB measurements representative of a group of workers with more than 1–2 years of service in the same job and notionally homogenous exposure conditions could serve as a cross-sectional predictor of atmospheric Mn exposure in the current job, as well as for surveillance of Mn exposure trends over time. Correlations at the individual level were only modest for MnB (33% of the variance in log atmospheric Mn intensity in the current job was explained by log MnB), much worse for MnU (only 7%). However, a receiver operating characteristic (ROC) analysis was performed which showed that it is possible to use a MnB cut-off of 10 μg/l (the 95th percentile in the unexposed) to good effect as a screening tool to discriminate between individual exposures exceeding and falling below a relatively strict atmospheric Mn exposure threshold at the ACGIH threshold limit value (TLV) of 0.2 mg/m3. MnU has no utility as a measure of biological exposure nor does serum prolactin as a measure of biological effect. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANGANESE
KW - SMELTING
KW - BLOOD
KW - LUNGS -- Dust diseases
KW - INDUSTRIAL hygiene
KW - Biomarkers
KW - Exposure
KW - Manganese
KW - Prolactin
KW - Surveillance
N1 - Accession Number: 11464582; Myers, Jonathan E. 1; Email Address: myers@cormack.uct.ac.za Thompson, Mary Lou 1,2 Naik, Inakshi 3 Theodorou, Penny 3 Esswein, Eric 3,4 Tassell, Halina 3 Daya, Aarti 3 Renton, Kevin 3 Spies, Adri 3 Paicker, Janice 5 Young, Taryn 1 Jeebhay, Mohamed 1 Ramushu, Suzan 1 London, Leslie 1 Rees, David J. 3; Affiliation: 1: Occupational and Environmental Health Research Unit, School of Public Health and Primary Health Care, Faculty of Health Sciences, University of Cape Town, Anzio Road Observatory, 7925 Cape Town, South Africa 2: Department of Biostatistics, University of Washington, Seattle, WA, USA 3: National Centre for Occupational Health, Johannesburg, South Africa 4: National Institute for Occupational Safety and Health, Cleveland, OH, USA 5: South African Institute for Medical Research, Johannesburg, South Africa; Source Info: Dec2003, Vol. 24 Issue 6, p875; Subject Term: MANGANESE; Subject Term: SMELTING; Subject Term: BLOOD; Subject Term: LUNGS -- Dust diseases; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Exposure; Author-Supplied Keyword: Manganese; Author-Supplied Keyword: Prolactin; Author-Supplied Keyword: Surveillance; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 331492 Secondary Smelting, Refining, and Alloying of Nonferrous Metal (except Copper and Aluminum); NAICS/Industry Codes: 331410 Nonferrous Metal (except Aluminum) Smelting and Refining; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0161-813X(03)00082-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Jonathan E.
AU - Thompson, Mary Lou
AU - Ramushu, Suzan
AU - Young, Taryn
AU - Jeebhay, Mohamed F.
AU - London, Leslie
AU - Esswein, Eric
AU - Renton, Kevin
AU - Spies, Adri
AU - Boulle, Andrew
AU - Naik, Inakshi
AU - Iregren, Anders
AU - Rees, David J.
T1 - The Nervous System Effects of Occupational Exposure on Workers in a South African Manganese Smelter
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2003/12//
VL - 24
IS - 6
M3 - Article
SP - 885
SN - 0161813X
AB - Five hundred and nine production workers at a manganese (Mn) smelting works comprising eight production facilities and 67 external controls were studied cross-sectionally for Mn related neuroehavioural effects. Exposure measures from personal sampling included Mn in inhalable dust as cumulative exposure indices (CEI) and average intensity (INT). Biological exposure and biological effect measures included blood (MnB), urine (MnU) manganese and serum prolactin. Endpoints included items from the Swedish nervous system questionnaire (Q16), World Health Organisation neurobehavioural core test battery (WHO NCTB), Swedish performance evaluation system (SPES), Luria–Nebraska (LN), and Danish product development (DPD) test batteries, and a brief clinical examination. Potential confounders and effect modifiers included age, educational level, alcohol and tobacco consumption, neurotoxic exposures in previous work, past medical history, previous head injury and home language. Associations were evaluated by multiple linear and logistic regression modelling. Modelling assumptions were tested. Average exposure intensity across all jobs ranged from near 0 (0.06 μg/m3) for external controls to 5.08 mg/m3 for inhalable Mn, and was greater than the ACGIH TLV for 69% of subjects. Results from the large number of tests performed resolved into three groups. Group 1 shows differences between external unexposed referents and all the exposed and/or differences between internal low exposed referents and the rest of the exposed but no further exposure–response relationships. It includes the Santa Ana, Benton and digit-span tests from the WHO NCTB; the hand tapping and endurance tapping tests from the SPES; Luria–Nebraska item 2L; questionnaire items tired, depressed, irritated, having to take notes in order to remember things, and subjects’ perception that they had sex less often than normal; a test of clinical abnormality; and increased sway under two conditions (eyes open without foot insulation, eyes open with foot insulation). Group 2 shows the presence of a more substantive exposure–response relationship. It consists of only two tests: and includes the WHO digit-symbol test (although the major impact is at low exposure and therefore counterintuitive, arguably placing this test in group 3) and the LN item 1R which has a step to a poorer score at high exposure. Group 3 contains the overwhelming majority of test results (almost all the questionnaire items, almost all the DPD tests including tremor, sway and diadochokinesia, and serum prolactin) which were either null or counterintuitive (did not make sense). The CEI was the strongest predictor of test abnormalities, except for the clinical test which was more strongly associated with blood manganese. Despite a comprehensive range of endpoints, and levels of exposure ranging from environmental to industrial, this large study of Mn workers found little convincing evidence for a continuum of effects, contributing further questions to current debates about the adequacy of the current ACGIH TLV. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANGANESE
KW - SMELTING
KW - URINE
KW - BLOOD
KW - BEHAVIORAL toxicology
KW - INDUSTRIAL hygiene
KW - Exposure
KW - Manganese
KW - Neurobehavioural
KW - Neurotoxicity
KW - Occupational
N1 - Accession Number: 11464583; Myers, Jonathan E. 1; Email Address: myers@cormack.uct.ac.za Thompson, Mary Lou 1,2 Ramushu, Suzan 1 Young, Taryn 1 Jeebhay, Mohamed F. 1 London, Leslie 1 Esswein, Eric 3,4 Renton, Kevin 3 Spies, Adri 3 Boulle, Andrew 1 Naik, Inakshi 3 Iregren, Anders 5 Rees, David J. 3; Affiliation: 1: Occupational and Environmental Health Research Unit, School of Public Health and Primary Health Care, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa 2: Department of Biostatistics, University of Washington, Seattle, WA, USA 3: National Centre for Occupational Health, Johannesburg, South Africa 4: National Institute for Occupational Safety and Health, Cleveland, OH, USA 5: National Institute for Working Life, Solna, Sweden; Source Info: Dec2003, Vol. 24 Issue 6, p885; Subject Term: MANGANESE; Subject Term: SMELTING; Subject Term: URINE; Subject Term: BLOOD; Subject Term: BEHAVIORAL toxicology; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: Exposure; Author-Supplied Keyword: Manganese; Author-Supplied Keyword: Neurobehavioural; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Occupational; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 331410 Nonferrous Metal (except Aluminum) Smelting and Refining; NAICS/Industry Codes: 331492 Secondary Smelting, Refining, and Alloying of Nonferrous Metal (except Copper and Aluminum); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0161-813X(03)00081-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zengjun Xu, Theresa M.
AU - Seidler, Frederic J.
AU - Tate, Charlotte A.
AU - Garcia, Stephanie J.
AU - Slikker Jr., William
AU - Slotkin, Theodore A.
T1 - Sex-selective hippocampal alterations after adolescent nicotine administration: Effects on neurospecific proteins.
JO - Nicotine & Tobacco Research
JF - Nicotine & Tobacco Research
Y1 - 2003/12//
VL - 5
IS - 6
M3 - Article
SP - 955
EP - 960
SN - 14622203
AB - Nicotine is a neuroteratogen that targets cell development and synaptic function into adolescence, when smoking typically commences. We used a rat model of adolescent nicotine exposure to characterize the types of cells involved in hippocampal alterations. Nicotine was given to adolescent rats by minipump infusions from postnatal day (PN) 30 to PN47.5, using a dose rate (6 mg/kg/day) that replicates the plasma nicotine levels found in smokers. We examined specific neuronal and astrocyte proteins in the posttreatment period (PN50, PN60), when deficits in neurotransmission first appear: glial fibrillary acidic protein (GFAP), a marker for astrocytes; neurofilament 68-kDa protein (NF68), which is concentrated in the neuronal perikaryon and proximal neurites; and neurofilament 200-kDa protein (NF200), which is found in axonal projections distal to the perikaryon. Adolescent nicotine treatment evoked a significant decrease across all three markers, with the effect restricted to females and showing intensification between PN50 and PN60. These changes correspond to the sex-selectivity and temporal course over which other biomarkers indicate hippocampal cell damage and alterations in synaptic function. We conclude that administration of nicotine to adolescent rats alters neuroproteins in the female hippocampus during withdrawal, effects that could contribute to neurobehavioral deficits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nicotine & Tobacco Research is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NICOTINE
KW - HIPPOCAMPUS (Brain)
KW - ASTROCYTES
KW - NEURAL transmission
KW - TEENAGERS -- Substance use
KW - TOBACCO use
N1 - Accession Number: 11692649; Zengjun Xu, Theresa M. 1 Seidler, Frederic J. 2 Tate, Charlotte A. 2 Garcia, Stephanie J. 2 Slikker Jr., William 3 Slotkin, Theodore A. 2; Email Address: t.slotkin@duke.edu; Affiliation: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences 2: Department of Pharmacology and Cancer Biology, Duke University Medical Center 3: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR and Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration; Source Info: Dec2003, Vol. 5 Issue 6, p955; Subject Term: NICOTINE; Subject Term: HIPPOCAMPUS (Brain); Subject Term: ASTROCYTES; Subject Term: NEURAL transmission; Subject Term: TEENAGERS -- Substance use; Subject Term: TOBACCO use; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whelan, E. A.
AU - Lawson, C. C.
AU - Grajewski, B.
AU - Petersen, M. R.
AU - Pinkerton, L. E.
AU - Ward, E. M.
AU - Schnorr, T. M.
T1 - Prevalence of respiratory symptoms among female flight attendants and teachers.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2003/12//
VL - 60
IS - 12
M3 - Article
SP - 929
EP - 934
SN - 13510711
AB - Background: Potential health effects of the indoor environment in office buildings and aircraft have generated considerable concern in recent years. Aims: To analyse the prevalence of self reported respiratory symptoms and illnesses in flight attendants (FAs) and schoolteachers. Methods: Data were collected as part of a study of reproductive health among female FAs. The prevalences of work related eye, nose, and throat symptoms, wheezing, physician diagnosed asthma, chest illness, and cold or flu were calculated and stratified by smoking status in 1824 FAs and 331 schoolteachers. Results: FAs and teachers were significantly more likely to report work related eye (12.4% and 7.4%, respectively), nose (15.7% and 8.1%), and throat symptoms (7.5% and 5.7%) than were other working women (2.9% eye, 2.7% nose, and 1.3% throat symptoms). FAs were significantly more likely than teachers and referent working women to report chest illness during the prior three years (32.9%, 19.3%, 7.2%, respectively). Both study groups were more likely to report five or more episodes of cold or flu in the past year than were other working women (10.2% of FAs, 8.2% of teachers, 2.3% of referents), and both groups were more likely to report wheezing than other working women (22.8% of FAs, 28.4% of teachers, 16.4% of referents). FAs were significantly less likely than teachers and other working women to report ever having been diagnosed with asthma (8.2%, 13.3%, 11.8%, respectively). Conclusions: Overall, FAs and schoolteachers report a higher prevalence of work related upper respiratory symptoms, chest illness, and cold or flu than the general working population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health
KW - Asthma
KW - Respiratory diseases
KW - Flight attendants
KW - Wheeze
KW - Asthmatics
N1 - Accession Number: 12181180; Whelan, E. A. 1; Email Address: EWhelan@cdc.gov; Lawson, C. C. 2; Grajewski, B. 2; Petersen, M. R. 2; Pinkerton, L. E. 2; Ward, E. M. 2; Schnorr, T. M. 2; Affiliations: 1: Industrywide Studies Branch, DSHEFS, NIOSH, 4676 Columbia Parkway, R-15, Cincinnati, Ohio 45226, USA; 2: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio, USA; Issue Info: Dec2003, Vol. 60 Issue 12, p929; Thesaurus Term: Health; Thesaurus Term: Asthma; Subject Term: Respiratory diseases; Subject Term: Flight attendants; Subject Term: Wheeze; Subject Term: Asthmatics; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wang, X.-R.
AU - Eisen, E. A.
AU - Zhang, H.-X.
AU - Sun, B.-X.
AU - Dai, H.-L.
AU - Pan, L.-D.
AU - Wegman, D. H.
AU - Olenchock, S. A.
AU - Christiani, D. C.
T1 - Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2003/12//
VL - 60
IS - 12
M3 - Article
SP - 935
EP - 941
SN - 13510711
AB - Aims: To determine chronic effects of long term exposure to cotton dust and endotoxin on incidence of respiratory symptoms and the effect of cessation of exposure. Methods: Respiratory health in 429 Chinese cotton textile workers (study group) and 449 silk textile workers (control group) was followed prospectively from 1981 to 1996. Byssinosis, chest tightness, and non-specific respiratory symptoms were assessed by means of identical standardised questionnaires at four time points. Exposures to cotton dust and endotoxin were estimated using area samples collected at each survey. Incidence and persistence of symptoms were examined in relation to cumulative exposure and exposure cessation using generalised estimating equations (GEE). Results: Among cotton workers, the cumulative incidence of byssinosis and chest tightness was 24% and 23%, respectively, and was significantly more common in smokers than in non-smokers. A high proportion of symptoms was found to be intermittent, rather than persistent. Among silk workers, no typical byssinosis was identified; the incidence of chest tightness was 10%. Chronic bronchitis, cough, and dyspnoea were more common and persistent in the cotton group than in the silk group. Significantly lower odds ratios for symptoms were observed in cotton workers who left the cotton mills; risk was also related to years since last worked. Multivariate analysis indicated a trend for higher cumulative exposure to endotoxin in relation to a higher risk for byssinosis. Conclusion: Chronic exposure to cotton dust is related to both work specific and non-specific respiratory symptoms. Byssinosis is more strongly associated with exposure to endotoxin than to dust. Cessation of exposure may improve the respiratory health of cotton textile workers; the improvement appears to increase with time since last exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Endotoxins
KW - Textile workers
KW - Chronic diseases
KW - Cotton dust
KW - China
N1 - Accession Number: 12181181; Wang, X.-R. 1; Eisen, E. A. 1; Zhang, H.-X. 2; Sun, B.-X. 2; Dai, H.-L. 2; Pan, L.-D. 2; Wegman, D. H. 1; Olenchock, S. A. 3; Christiani, D. C. 1,4; Email Address: dchris@hohp.harvard.edu; Affiliations: 1: Department of Environmental Health (Occupational Health Program), Harvard School of Public Health, Boston, MA, USA; 2: First Hospital of the Shanghai Textile Bureau, Shanghai, China; 3: National Institute for Occupational Safety and Health, Morgantown, WV, USA; 4: Pulmonary and Critical Care Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA; Issue Info: Dec2003, Vol. 60 Issue 12, p935; Thesaurus Term: HEALTH; Thesaurus Term: Endotoxins; Subject Term: Textile workers; Subject Term: Chronic diseases; Subject Term: Cotton dust; Subject: China; NAICS/Industry Codes: 313310 Textile and Fabric Finishing Mills; NAICS/Industry Codes: 314990 All other textile product mills; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; Number of Pages: 7p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106770985
T1 - Prevalence of respiratory symptoms among female flight attendants and teachers.
AU - Whelan EA
AU - Lawson CC
AU - Grajewski B
AU - Petersen MR
AU - Pinkerton LE
AU - Ward EM
AU - Schnorr TM
Y1 - 2003/12//
N1 - Accession Number: 106770985. Language: English. Entry Date: 20040827. Revision Date: 20150711. Publication Type: Journal Article; questionnaire/scale; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Supported, in part, by interagency agreements with the Federal Aviation Administration and the Department of Defense Women's Health Research Program. NLM UID: 9422759.
KW - Aerospace Medicine
KW - Aircraft
KW - Occupational Diseases -- Epidemiology
KW - Respiratory Tract Diseases -- Epidemiology
KW - Teaching
KW - Adult
KW - Air Pollution, Indoor -- Adverse Effects
KW - Chi Square Test
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - Interviews
KW - Middle Age
KW - North Carolina
KW - Prevalence
KW - Questionnaires
KW - Respiratory Sounds -- Etiology
KW - Respiratory Tract Diseases -- Etiology
KW - Schools
KW - T-Tests
KW - Telephone
KW - United States
KW - Work Environment
KW - Funding Source
KW - Human
SP - 929
EP - 934
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 60
IS - 12
PB - BMJ Publishing Group
AB - BACKGROUND: Potential health effects of the indoor environment in office buildings and aircraft have generated considerable concern in recent years. AIMS: To analyse the prevalence of self reported respiratory symptoms and illnesses in flight attendants (FAs) and schoolteachers. METHODS: Data were collected as part of a study of reproductive health among female FAs. The prevalences of work related eye, nose, and throat symptoms, wheezing, physician diagnosed asthma, chest illness, and cold or flu were calculated and stratified by smoking status in 1824 FAs and 331 schoolteachers. RESULTS: FAs and teachers were significantly more likely to report work related eye (12.4% and 7.4 %, respectively), nose (15.7% and 8.1%), and throat symptoms (7.5% and 5.7%) than were other working women (2.9% eye, 2.7% nose, and 1.3% throat symptoms). FAs were significantly more likely than teachers and referent working women to report chest illness during the prior three years (32.9%, 19.3%, 7.2%, respectively). Both study groups were more likely to report five or more episodes of cold or flu in the past year than were other working women (10.2% of FAs, 8.2% of teachers, 2.3% of referents), and both groups were more likely to report wheezing than other working women (22.8% of FAs, 28.4% of teachers, 16.4% of referents). FAs were significantly less likely than teachers and other working women to report ever having been diagnosed with asthma (8.2%, 13.3%, 11.8%, respectively). CONCLUSIONS: Overall, FAs and schoolteachers report a higher prevalence of work related upper respiratory symptoms, chest illness, and cold or flu than the general working population.
SN - 1351-0711
AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226; EWhelan@cdc.gov
U2 - PMID: 14634183.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carmona, Richard H.
T1 - BRIDGING THE GAP.
JO - Officer
JF - Officer
Y1 - 2003/12//
VL - 80
IS - 9
M3 - Article
SP - 60
EP - 62
SN - 00300268
AB - Focuses on the United States Public Health Service (PHS) Commissioned Corps and its role in public health preparedness during terrorist attacks and other emergencies. Public health challenges encountered from World War I to September 11, 2001 terrorist attacks; Preparation for terrorist attacks and other public health emergencies pursuant to the Public Health Security and Bioterrorism Preparedness and Response Act of 2003; Changes needed in PHS Commissioned Corps; Role of PHS Inactive Reserve in public health preparedness.
KW - PUBLIC health
KW - TERRORISM
KW - EMERGENCY medical services
KW - PREPAREDNESS
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 12354165; Carmona, Richard H. 1; Affiliation: 1: U.S. Public Health Service, Department of Health and Human Services; Source Info: Dec2003, Vol. 80 Issue 9, p60; Subject Term: PUBLIC health; Subject Term: TERRORISM; Subject Term: EMERGENCY medical services; Subject Term: PREPAREDNESS; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Illustrations: 4 Color Photographs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sonia Tabacova
AU - Ruth Little
AU - Yi Tsong
AU - Amarilys Vega
AU - Carole A. Kimmel
T1 - Adverse pregnancy outcomes associated with maternal enalapril antihypertensive treatment(The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the Food and Drug Administration or the US Environmental Protection Agency.)
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2003/12//
VL - 12
IS - 8
M3 - Article
SP - 633
EP - 646
SN - 10538569
AB - Adverse pregnancy outcomes following the use of angiotensin-converting enzyme (ACE) inhibitors, including enalapril, have been reported in descriptive studies. However, no analytical studies on the relationship between the adverse outcomes and enalapril gestational exposures are available. To explore the association between enalapril exposure and adverse outcomes in pregnancy, taking into account other possible risk factors. We analyzed a series of all usable cases reported to the FDA between 1986 and 2000 in which enalapril was a suspect drug for the observed adverse outcomes (N = 110). Parameters of exposure and reported outcomes as well as information on potentially confounding variables were systematically abstracted from this series by a single physician. Because exposure to ACE inhibitors after the first trimester of pregnancy had been associated with adverse outcomes in the existing literature, we divided the cases into those exposed in the first trimester only (considered as the baseline group) and cases exposed beyond or after this time. Frequency of reported adverse outcomes in the second group was compared with those in the baseline group; odds ratios were computed, taking account of potentially confounding variables by logistic regression where appropriate. Exposure to enalapril after the first trimester of pregnancy was strongly associated with oligohydramnios and specific adverse outcomes thought to be secondary to reduced amniotic fluid volume (limb deformities, cranial ossification deficits, lung hypoplasia), as well as with neonatal renal failure. The relationship did not change after taking numerous potential confounders into account, including duration of exposure, concomitant drug use, maternal age, concurrent disease, neonatal gender, and gestational age at birth. Such a pattern of abnormalities is considered to be a consequence of the effect of ACE inhibition on fetal renal function that develops after the first trimester. The specificity and temporality of the observed adverse manifestations suggest a causal relationship to enalapril exposure. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs
KW - Enzyme inhibitors
KW - Pregnancy
KW - ACE inhibitors
KW - Pregnant women
N1 - Accession Number: 11684069; Sonia Tabacova 1; Ruth Little 2; Yi Tsong 3; Amarilys Vega 3; Carole A. Kimmel 4; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Rockville, MD, USA; 2: National Institute for Environmental Health Sciences, Research Triangle Park, NC, USA; 3: Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA; 4: National Center for Environmental Assessment, Office for Research and Development, US Environmental Protection Agency, Washington, DC, USA; Issue Info: Dec2003, Vol. 12 Issue 8, p633; Thesaurus Term: Drugs; Thesaurus Term: Enzyme inhibitors; Subject Term: Pregnancy; Subject Term: ACE inhibitors; Subject Term: Pregnant women; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106603484
T1 - Surviving suicide: the ones left behind.
AU - Simon L
A2 - Geller JL
Y1 - 2003/12//
N1 - Accession Number: 106603484. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Grief
KW - Suicide
KW - Survivors -- Psychosocial Factors
KW - United Kingdom
SP - 1596
EP - 1597
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 54
IS - 12
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Researcher, Center for Mental Health Services Research, Dept of Psychiatry, University of Massachusetts Medical School, Worcester, MA
U2 - PMID: 14645797.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Contrera, Joseph F.
AU - Matthews, Edwin J.
AU - Daniel Benz, R.
T1 - Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2003/12//
VL - 38
IS - 3
M3 - Article
SP - 243
SN - 02732300
AB - MDL QSAR (formerly SciVision QSAR IS) software is one of the several software systems under evaluation by the Informatics and Computational Safety Analysis Staff (ICSAS) of the FDA Center for Drug Evaluation and Research for regulatory and scientific decision support applications. MDL QSAR software contains an integrated set of tools for similarity searching, compound clustering, and modeling molecular structure related parameters that includes 240 electrotopological E-state, connectivity, and other descriptors. These molecular descriptors can be statistically correlated with toxicological or biological endpoints. The goal of this research was to evaluate the feasibility of using MDL QSAR software to develop structure–activity relationship (SAR) models that can be used to predict the carcinogenic potential of pharmaceuticals and organic chemicals. A validation study of 108 compounds that include 86 pharmaceuticals and 22 chemicals that were not present in a control rodent carcinogenicity data set of 1275 compounds demonstrated that MDL QSAR models had excellent coverage (93%) and good sensitivity (72%) and specificity (72%) for rodent carcinogenicity. The software correctly predicted 72% of non-carcinogenic compounds and compounds with carcinogenic findings. E-state descriptors contributed to more than half of the SAR models used to predict carcinogenic activity. We believe that electrotopological E-state descriptors and QSAR IS (MDL QSAR) software are promising new in silico approaches for modeling and predicting rodent carcinogenicity and may have application for other toxicological endpoints. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - QSAR (Biochemistry)
KW - Drugs
KW - Toxicology
KW - Carcinogenicity
KW - Computational toxicology
KW - E-state descriptors
KW - Electrotopological
KW - In silico
KW - Predictive modeling
KW - Quantitative structure–activity relationship (QSAR)
N1 - Accession Number: 11399623; Contrera, Joseph F.; Email Address: contrerajf@cder.fda.gov; Matthews, Edwin J. 1; Daniel Benz, R. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science (HFD-901), Informatics and Computational Safety Analysis Staff (ICSAS), 5600 Fishers Lane, Rockville, MD 20857, USA; Issue Info: Dec2003, Vol. 38 Issue 3, p243; Thesaurus Term: Carcinogenesis; Thesaurus Term: QSAR (Biochemistry); Thesaurus Term: Drugs; Thesaurus Term: Toxicology; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: E-state descriptors; Author-Supplied Keyword: Electrotopological; Author-Supplied Keyword: In silico; Author-Supplied Keyword: Predictive modeling; Author-Supplied Keyword: Quantitative structure–activity relationship (QSAR); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/S0273-2300(03)00071-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106652000
T1 - Epidemiology of tuberculosis.
AU - Iademarco MF
AU - Castro KG
Y1 - 2003/12//2003 Dec
N1 - Accession Number: 106652000. Language: English. Entry Date: 20041015. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; USA. NLM UID: 8700961.
KW - Tuberculosis -- Epidemiology
KW - World Health
KW - Incidence
SP - 225
EP - 240
JO - Seminars in Respiratory Infections
JF - Seminars in Respiratory Infections
JA - SEMIN RESPIR INFECT
VL - 18
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - In the United States, many people erroneously think that tuberculosis (TB) is a disease of the past--an illness that no longer constitutes a public health threat. In reality, TB is one of the leading global causes of morbidity and mortality. According to the World Health Organization, which compiles annual country profiles of reported TB cases using standardized case definitions, 2.4 million cases were reported in 2001. However, because of underreporting, the number of new TB cases is estimated to be 8.3 million, including 1.8 million deaths. In the United States, after more than 3 decades of steady downward trends, an unprecedented resurgence of TB occurred between 1985 and 1992. This increase was associated with deficient infrastructure, the human immunodeficiency virus (HIV) epidemic, immigration, outbreaks in congregate settings, and widespread occurrence of multidrug resistant TB strains. The resultant increased concerns provided the impetus for the development of a national action plan to combat MDR and the mobilization of new resources. Consequently, the incidence of TB cases has decreased from 1992 through 2002. New challenges are evident and must be addressed to achieve the agreed-on goal of eliminating TB in the United States. This report describes the global epidemiology of TB and the epidemiology in the United States, and outlines future challenges to the elimination of TB in the United States. Copyright © 2003 by Elsevier Science (USA).
SN - 0882-0546
AD - United States Public Health Service, Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Department of Health and Human Services, School of Medicine and Rollins School of Public Health, Emory University, Atlanta, GA; miademarco@cdc.gov
U2 - PMID: 14679472.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Middaugh, Lawrence D.
AU - Dow-Edwards, Diana
AU - Li, Abby A.
AU - Sandler, J. David
AU - Seed, Jennifer
AU - Sheets, Larry P.
AU - Shuey, Dana L.
AU - Slikker Jr., William
AU - Weisenburger, Walter P.
AU - Wise, L. David
AU - Selwyn, Murray R.
T1 - Neurobehavioral Assessment: A Survey of Use and Value in Safety Assessment Studies.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/12//
VL - 76
IS - 2
M3 - Article
SP - 250
EP - 261
PB - Oxford University Press / USA
SN - 10966080
AB - This report describes the results of a survey designed to evaluate the contribution of F1 neurobehavioral testing to hazard identification and characterization in safety assessment studies. (To review the details of the distributed survey, please see the supplementary data for this article on the journal''s Web site.) The survey provided information about studies completed in industrial laboratories in the United States, Europe, and Japan since 1990 on 174 compounds. The types of compounds included were pharmaceutical (81%), agricultural (7%), industrial (1%), or were undefined (10%). Information collected included the intended use of the test agent, general study design and methodology, the types and characteristics of F1 behavioral evaluations, and the frequency with which agents affected neurobehavioral parameters in comparison to other F0 and F1 generation parameters. F1 general toxicology parameters such as mortality, pre- and postweaning body weight, and food intake were assessed in most studies and were affected more frequently than other parameters by the test agents. F1 behavioral parameters were assessed less consistently across studies, and were less frequently affected by the agents tested. Although affected by agents less often than general toxicology parameters, F1 behavioral parameters along with other parameters defined the no-observed-effect level (NOEL) in 17/113 (15%) of studies and solely defined the NOEL in 3/113 (2.6%) of studies. Thus, F1 behavioral parameters sometimes improved on the standard toxicological measures of hazard identification. While not detecting agent effects as readily as some measures, the F1 behavioral parameters provide information about agent effects on specialized functions of developing offspring not provided by other standard measures of toxicity. The survey results emphasize the need for further research into the methods of behavioral assessment as well as the mechanisms underlying the neurobehavioral alterations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Surveys
KW - Engineering laboratories
KW - Behavioral assessment
KW - Industrial research -- Laboratories
KW - United States
KW - Europe
KW - Japan
KW - developmental toxicology
KW - F1 generation assessment
KW - neurobehavioral toxicology
KW - perinatal drug exposure
N1 - Accession Number: 20605716; Middaugh, Lawrence D. 1; Email Address: middauld@musc.edu; Dow-Edwards, Diana 2; Li, Abby A. 3; Sandler, J. David 4; Seed, Jennifer 5; Sheets, Larry P. 6; Shuey, Dana L. 7; Slikker Jr., William 8; Weisenburger, Walter P. 9; Wise, L. David 10; Selwyn, Murray R. 11; Affiliations: 1: Department of Psychiatry and Behavioral Science, Medical University of South Carolina, Charleston, South Carolina 29425; 2: Department of Physiology and Pharmacology, SUNY-Brooklyn, Brooklyn, New York 11203; 3: Exponent, Inc., San Francisco, California 94114; 4: International Life Sciences Institute, Health and Environmental Sciences Institute, Washington, District of Columbia 20005; 5: Environmental Protection Agency, Washington, District of Columbia 20460; 6: Toxicology Department, Bayer CropScience, Stilwell, Kansas 66085; 7: Endo Pharmaceuticals, Inc., Chadds Ford, Pennsylvania 19317; 8: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; 9: Central Research Division, Drug Safety Evaluation, Pfizer, Inc., Groton, Connecticut 06340; 10: Merck Research Laboratories, West Point, Pennsylvania 19486; 11: PAREXEL International, Durham, North Carolina 27713; Issue Info: Dec2003, Vol. 76 Issue 2, p250; Subject Term: Surveys; Subject Term: Engineering laboratories; Subject Term: Behavioral assessment; Subject Term: Industrial research -- Laboratories; Subject: United States; Subject: Europe; Subject: Japan; Author-Supplied Keyword: developmental toxicology; Author-Supplied Keyword: F1 generation assessment; Author-Supplied Keyword: neurobehavioral toxicology; Author-Supplied Keyword: perinatal drug exposure; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1093/toxsci/kfg211
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keil, Deborah E.
AU - Warren, D. Alan
AU - Jenny, Matthew J.
AU - EuDaly, Jackie G.
AU - Smythe, Joshua
AU - Peden-Adams, Margie M.
T1 - Immunological Function in Mice Exposed to JP-8 Jet Fuel In Utero.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2003/12//
VL - 76
IS - 2
M3 - Article
SP - 347
EP - 356
PB - Oxford University Press / USA
SN - 10966080
AB - Immunological parameters, host resistance, and thyroid hormones were evaluated in F1 mice exposed in utero to jet propulsion fuel-8 (JP-8). C57BL/6 pregnant dams (mated with C3H/HeJ males) were gavaged daily on gestation days 6-15 with JP-8 in a vehicle of olive oil at 0, 1000, or 2000 mg/kg. At weaning (3 weeks of age), no significant differences were observed in body, liver, spleen, or thymus weight, splenic and thymic cellularity, splenic CD4/CD8 lymphocyte subpopulations, or T-cell proliferation. Yet, lymphocytic proliferative responses to B-cell mitogens were suppressed in the 2000 mg/kg treatment group. In addition, thymic CD4−/CD8+ cells were significantly increased. By adulthood (8 weeks of age), lymphocyte proliferative responses and the alteration in thymic CD4−/CD8+ cells had returned to normal. However, splenic weight and thymic cellularity were altered, and the IgM plaque forming cell response was suppressed by 46% and 81% in the 1000 and 2000 mg/kg treatment groups, respectively. Furthermore, a 38% decrease was detected in the total T4 serum hormone level at 2000 mg/kg. In F1 adults, no significant alterations were observed in natural killer cell activity, T-cell lymphocyte proliferation, bone marrow cellularity and proliferative responses, complete blood counts, peritoneal and splenic cellularity, liver, kidney, or thymus weight, macrophage phagocytosis or nitric oxide production, splenic CD4/CD8 lymphocyte subpopulations, or total T3 serum hormone levels. Host resistance models in treated F1 adults demonstrated that immunological responses were normal after challenge with Listeria monocytogenes, but heightened susceptibility to B16F10 tumor challenge was seen at both treatment levels. This study demonstrates that prenatal exposure to JP-8 can target the developing murine fetus and result in impaired immune function and altered T4 levels in adulthood. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animal models in research
KW - Thyroid hormones
KW - Mice as laboratory animals
KW - Liver
KW - Kidneys
KW - Killer cells
KW - host resistance
KW - immunological parameters
KW - jet propulsion fuel-8
KW - JP-8
KW - thyroid hormones
N1 - Accession Number: 20605708; Keil, Deborah E. 1,2; Email Address: dkeil@cdc.gov; Warren, D. Alan 3; Jenny, Matthew J. 4; EuDaly, Jackie G. 2; Smythe, Joshua 2; Peden-Adams, Margie M. 2,4,5; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 2: Department of Health Professions, Medical University of South Carolina, Charleston, South Carolina 29425; 3: Environmental Health Science, University of South Carolina-Beaufort, Beaufort, South Carolina 29902; 4: Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, South Carolina 29425; 5: Department of Medicine/Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425; Issue Info: Dec2003, Vol. 76 Issue 2, p347; Thesaurus Term: Animal models in research; Subject Term: Thyroid hormones; Subject Term: Mice as laboratory animals; Subject Term: Liver; Subject Term: Kidneys; Subject Term: Killer cells; Author-Supplied Keyword: host resistance; Author-Supplied Keyword: immunological parameters; Author-Supplied Keyword: jet propulsion fuel-8; Author-Supplied Keyword: JP-8; Author-Supplied Keyword: thyroid hormones; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfg244
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20605708&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weaver, James L.
AU - Staten, David
AU - Swann, Joslyn
AU - Armstrong, George
AU - Bates, Melissa
AU - Hastings, Kenneth L.
T1 - Detection of systemic hypersensitivity to drugs using standard guinea pig assays
JO - Toxicology
JF - Toxicology
Y1 - 2003/12//
VL - 193
IS - 3
M3 - Article
SP - 203
SN - 0300483X
AB - The most commonly used assays designed to detect either skin or systemic immune-based hypersensitivity reactions are those using guinea pigs (GP). We obtained data from various FDA records to evaluate the correlation between GP assay results and reported post-marketing systemic hypersensitivity reactions. We examined the new drug application (NDA) reviews of approved drugs for the results of GP assays. Post-marketing human data were extracted from the FDA adverse event reporting system (AERS). Drug usage data were obtained from a commercial database maintained by IMS Health Inc. We found 83 (21%) of 396 drugs approved between 1978 and 1998 had reported GP test results. Among these 83 drugs, 14 (17%) were found to have positive results in at least one GP assay. Simple reporting index (RI) values for systemic hypersensitivity reactions were calculated from AERS data and usage to produce the index of adverse event reports per million shipping units of drug. A variety of definitions of positive human response were examined. A statistically significant association was seen for rash between post-marketing and clinical trials adverse event reports. No statistically significant associations between human data and GP test results were observed. These data suggest that standard GP assays have limited ability to predict human systemic hypersensitivity potential for pharmaceuticals. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - DRUGS
KW - GUINEA pigs
KW - active systemic anaphylaxis (ASA)
KW - adverse event (AE)
KW - adverse event report (AER)
KW - adverse event reporting system (AERS)
KW - Buehler patch test (BPT)
KW - Center for Drug Evaluation and Research (CDER)
KW - delayed-type hypersensitivity (DTH)
KW - Drug
KW - Drug allergy
KW - Guinea pig
KW - guinea pig (GP)
KW - Hypersensitivity
KW - new drug application (NDA)
KW - new molecular entity (NME)
KW - open epicutaneous test (OET)
KW - passive cutaneous anaphylaxis (PCA)
KW - positive predictive value (PPV)
KW - reporting index (RI)
N1 - Accession Number: 11251833; Weaver, James L. 1; Email Address: weaver@cder.fda.gov Staten, David 2 Swann, Joslyn 3 Armstrong, George 3 Bates, Melissa 3 Hastings, Kenneth L. 4; Affiliation: 1: Office of Testing and Research, Division of Applied Pharmacology Research, Center for Drug Evaluation and Research (CDER), MOD-1, 8301 Muirkirk Rd, Laurel, MD 20708, USA 2: Division of Vaccines and Related Product Applications, Center for Biologics Evaluation and Research, Rockville, MD, USA 3: Office of Drug Safety, CDER, Rockville, MD, USA 4: Division of Special Pathogen and Immunologic Drug Products, CDER, US Food and Drug Administration, Rockville, MD, USA; Source Info: Dec2003, Vol. 193 Issue 3, p203; Subject Term: ALLERGY; Subject Term: DRUGS; Subject Term: GUINEA pigs; Author-Supplied Keyword: active systemic anaphylaxis (ASA); Author-Supplied Keyword: adverse event (AE); Author-Supplied Keyword: adverse event report (AER); Author-Supplied Keyword: adverse event reporting system (AERS); Author-Supplied Keyword: Buehler patch test (BPT); Author-Supplied Keyword: Center for Drug Evaluation and Research (CDER); Author-Supplied Keyword: delayed-type hypersensitivity (DTH); Author-Supplied Keyword: Drug; Author-Supplied Keyword: Drug allergy; Author-Supplied Keyword: Guinea pig; Author-Supplied Keyword: guinea pig (GP); Author-Supplied Keyword: Hypersensitivity; Author-Supplied Keyword: new drug application (NDA); Author-Supplied Keyword: new molecular entity (NME); Author-Supplied Keyword: open epicutaneous test (OET); Author-Supplied Keyword: passive cutaneous anaphylaxis (PCA); Author-Supplied Keyword: positive predictive value (PPV); Author-Supplied Keyword: reporting index (RI); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/S0300-483X(03)00267-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11251833&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leakey, Julian E.A.
AU - Seng, John E.
AU - Allaben, William T.
T1 - Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2003/12//
VL - 193
IS - 2
M3 - Article
SP - 237
SN - 0041008X
AB - In B6C3F1 mice, the rate of body growth influences susceptibility to liver neoplasia and large variations in body weight can complicate the interpretation of bioassay data. The relationship between body weight and liver tumor incidence was calculated for historical control populations of male and female ad libitum-fed mice (approx. 2750 and 2300 animals, respectively) and in populations of male and female mice which had been subjected to forced body weight reduction due to either dietary restriction or exposure to noncarcinogenic chemicals (approx. 1600 and 1700, respectively). Resulting tumor risk data were then used to construct idealized weight curves for male and female B6C3F1 mice; these curves predict a terminal background liver tumor incidence of 15–20%. Use of dietary control to manipulate body growth of male B6C3F1 mice to fit the idealized weight curve was evaluated in a 2-year bioassay of chloral hydrate. Cohorts of mice were successfully maintained at weights approximating their idealized target weights throughout the study. These mice exhibited less body weight variation than their ad libitum-fed counterparts (e.g., standard deviations of body weight were 1.4 and 3.4 g for respective control groups at 36 weeks). Historical control body weight and tumor risk data from the two male mouse populations were utilized to predict background liver tumor rates for each experimental group of the chloral hydrate study. The predicted background tumor rates closely matched the observed rates for both the dietary controlled and ad libitum-fed chloral hydrate control groups when each mouse was evaluated according to either its weekly food consumption or its weekly change in body weight. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GROWTH
KW - Mammal growth
KW - Body weight
KW - Tumors
KW - Liver
KW - Chloral hydrate
KW - Dietary restriction
KW - Mouse liver tumors
N1 - Accession Number: 11519317; Leakey, Julian E.A. 1; Email Address: jleakey@nctr.fda.gov; Seng, John E. 1; Allaben, William T. 1; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Dec2003, Vol. 193 Issue 2, p237; Thesaurus Term: GROWTH; Subject Term: Mammal growth; Subject Term: Body weight; Subject Term: Tumors; Subject Term: Liver; Author-Supplied Keyword: Chloral hydrate; Author-Supplied Keyword: Dietary restriction; Author-Supplied Keyword: Mouse liver tumors; Number of Pages: 29p; Document Type: Article
L3 - 10.1016/j.taap.2003.07.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11519317&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leakey, Julian E.A.
AU - Seng, John E.
AU - Latendresse, John R.
AU - Hussain, Nursreen
AU - Allen, Laura J.
AU - Allaben, William T.
T1 - Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2003/12//
VL - 193
IS - 2
M3 - Article
SP - 266
SN - 0041008X
AB - Chloral hydrate, which is used as a sedative in pediatric medicine and is a by-product of water chlorination, is hepatocarcinogenic in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which are associated with increased body weight. In this study, dietary control was used to manipulate body growth in male B6C3F1 mice in a 2-year bioassay of chloral hydrate. Male B6C3F1 mice were treated with water or 25, 50, or 100 mg/kg chloral hydrate by gavage. The study compared ad libitum-fed mice with dietary controlled mice. The latter received variably restricted feed allocations to maintain their body weights on a predetermined “idealized” weight curve predictive of a terminal background liver tumor incidence of 15–20%. These mice exhibited less individual body weight variation than did their ad libitum-fed counterparts. This was associated with a decreased variation in liver to body weight ratios, which allowed the demonstration of a statistically significant dose response to chloral hydrate in the dietary controlled, but not the ad libitum-fed, test groups. Chloral hydrate increased terminally adjusted liver tumor incidence in both dietary controlled (23.4, 23.9, 29.7, and 38.6% for the four dose groups, respectively) and ad libitum-fed mice (33.4, 52.6, 50.6, and 46.2%), but a statistically significant dose response was observed only in the dietary controlled mice. This dose response positively correlated with markers of peroxisomal proliferation in the dietary controlled mice only. The study suggests that dietary control not only improves terminal survival and decreases interassay variation, but also can increase assay sensitivity by decreasing intra-assay variation. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chloral
KW - Pediatrics
KW - Body weight
KW - Liver
KW - Chloral hydrate
KW - Dietary restriction
KW - Mouse liver tumors
N1 - Accession Number: 11519318; Leakey, Julian E.A. 1; Email Address: jleakey@nctr.fda.gov; Seng, John E. 1; Latendresse, John R. 1; Hussain, Nursreen 1; Allen, Laura J. 1; Allaben, William T. 1; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Dec2003, Vol. 193 Issue 2, p266; Thesaurus Term: Chloral; Subject Term: Pediatrics; Subject Term: Body weight; Subject Term: Liver; Author-Supplied Keyword: Chloral hydrate; Author-Supplied Keyword: Dietary restriction; Author-Supplied Keyword: Mouse liver tumors; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.taap.2003.07.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11519318&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Seng, John E.
AU - Agrawal, Nalini
AU - Horsley, Elizabeth T.M.
AU - Leakey, Tatiana I.
AU - Scherer, Erin M.
AU - Xia, Shijun
AU - Allaben, William T.
AU - Leakey, Julian E.A.
T1 - Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2003/12//
VL - 193
IS - 2
M3 - Article
SP - 281
SN - 0041008X
AB - Chloral hydrate is widely used as a sedative in pediatric medicine and is a by-product of water chlorination and a metabolic intermediate in the biotransformation of trichloroethylene. Chloral hydrate and its major metabolite, trichloroacetic acid, induce liver tumors in B6C3F1 mice, a strain that can exhibit high rates of background liver tumor incidence, which is associated with increased body weight. This report describes the influence of diet and body weight on the acute toxicity, hepatic enzyme response, and toxickinetics of chloral hydrate as part of a larger study investigating the carcinogenicity of chloral hydrate in ad libitum-fed and dietary controlled mice. Dietary control involves moderate food restriction to maintain the test animals at an idealized body weight. Mice were dosed with chloral hydrate at 0, 50, 100, 250, 500, and 1000 mg/kg daily, 5 days/week, by aqueous gavage for 2 weekly dosing cycles. Three diet groups were used: ad libitum, dietary control, and 40% caloric restriction. Both dietary control and caloric restriction slightly reduced acute toxicity of high doses of chloral hydrate and potentiated the induction of hepatic enzymes associated with peroxisome proliferation. Chloral hydrate toxicokinetics were investigated using blood samples obtained by sequential tail clipping and a microscale gas chromatography technique. It was rapidly cleared from serum within 3 h of dosing. Trichloroacetate was the major metabolite in serum in all three diet groups. Although the area under the curve values for serum trichloroacetate were slightly greater in the dietary controlled and calorically restricted groups than in the ad libitum-fed groups, this increase did not appear to completely account for the potentiation of hepatic enzyme induction by dietary restriction. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chloral
KW - Sedatives
KW - Metabolism
KW - Chlorination
KW - Chloral hydrate
KW - Dietary restriction
N1 - Accession Number: 11519319; Seng, John E. 1; Agrawal, Nalini 1; Horsley, Elizabeth T.M. 1; Leakey, Tatiana I. 1; Scherer, Erin M. 1; Xia, Shijun 1; Allaben, William T. 1; Leakey, Julian E.A. 1; Email Address: jleakey@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Dec2003, Vol. 193 Issue 2, p281; Thesaurus Term: Chloral; Subject Term: Sedatives; Subject Term: Metabolism; Subject Term: Chlorination; Author-Supplied Keyword: Chloral hydrate; Author-Supplied Keyword: Dietary restriction; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.taap.2003.07.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11519319&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2004-10841-003
AN - 2004-10841-003
AU - Cowell, Alexander
AU - McCarty, Dennis
AU - Woodward, Albert
T1 - Impact of federal substance abuse block grants on state substance abuse spending: Literature and data review.
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2003/12//
VL - 6
IS - 4
SP - 173
EP - 179
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Woodward, Albert, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Room 16-105, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-10841-003. PMID: 14713724 Partial author list: First Author & Affiliation: Cowell, Alexander; RTI International, Center for Interdisciplinary Substance Abuse Research, Research Triangle Park, NC, US. Release Date: 20040308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse Prevention; Drug Rehabilitation; Funding; Government Policy Making; Health Care Costs. Minor Descriptor: Drug Abuse. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Methodology: Literature Review. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2003.
AB - The federal Substance Abuse Prevention and Treatment Block Grant (SAPTBG) was established by the U.S. Congress to assist the states in funding substance abuse treatment services. Although the SAPTBG represents about 40 percent of public funding for treatment, how this federal assistance affects state treatment spending is not well understood. Published research has examined this topic, drawing on an approach from public finance economics. Based on a review of the literature and data, this paper suggests future avenues of research on the impact of the SAPTBG. The study reviews the relevant public finance economics literature and the data used in published work on the SAPTBG. Current literature examines only the effect of the block grant on expenditures by state substance abuse agencies. Additional analysis is needed to examine the impact of the SAPTBG on all sources of state funding and expenditures for substance abuse treatment. Ideas for additional research are presented at the end of this paper. The increasing interest of the U.S. Congress in evaluating the effectiveness of the many federal block grant programs requires that further analysis of the impact of the SAPTBG be undertaken. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state spending
KW - federal block grants
KW - substance abuse treatment
KW - substance abuse prevention
KW - federal Substance Abuse Prevention and Treatment Block Grant
KW - 2003
KW - Drug Abuse Prevention
KW - Drug Rehabilitation
KW - Funding
KW - Government Policy Making
KW - Health Care Costs
KW - Drug Abuse
KW - 2003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10841-003&site=ehost-live&scope=site
UR - awoodwar@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-11082-010
AN - 2003-11082-010
AU - Turk, Dennis C.
AU - Dworkin, Robert H.
AU - Allen, Robert R.
AU - Bellamy, Nicholas
AU - Brandenburg, Nancy
AU - Carr, Daniel B.
AU - Cleeland, Charles
AU - Dionne, Raymond
AU - Farrar, John T.
AU - Galer, Bradley S.
AU - Hewitt, David J.
AU - Jadad, Alejandro R.
AU - Katz, Nathaniel P.
AU - Kramer, Lynn D.
AU - Manning, Donald C.
AU - McCormick, Cynthia G.
AU - McDermott, Michael P.
AU - McGrath, Patrick
AU - Quessy, Steve
AU - Rappaport, Bob A.
AU - Robinson, James P.
AU - Royal, Mike A.
AU - Simon, Lee
AU - Stauffer, Joseph W.
AU - Stein, Wendy
AU - Tollett, Jane
AU - Witter, James
T1 - Core outcome domains for chronic pain clinical trials: IMMPACT recommendations.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2003/12//
VL - 106
IS - 3
SP - 337
EP - 345
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Turk, Dennis C., Department of Anesthesiology, University of Washington, Seattle, WA, US, 98195
N1 - Accession Number: 2003-11082-010. PMID: 14659516 Partial author list: First Author & Affiliation: Turk, Dennis C.; Department of Anesthesiology, University of Washington, Seattle, WA, US. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20040726. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Pain; Clinical Trials; Treatment Effectiveness Evaluation; Treatment Outcomes. Classification: Medical Treatment of Physical Illness (3363); Research Methods & Experimental Design (2260). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2003.
AB - The objective is to provide recommendations for the core outcome domains that should be considered by investigators conducting clinical trials of the efficacy and effectiveness of treatments for chronic pain. Development of a core set of outcome domains would facilitate comparison and pooling of data, encourage more complete reporting of outcomes, simplify the preparation and review of research proposals and manuscripts, and allow clinicians to make informed decisions regarding the risks and benefits of treatment. In the methodology, under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT), 27 specialists from academia, governmental agencies, and the pharmaceutical industry participated in a consensus meeting and identified core outcome domains that should be considered in clinical trials of treatments for chronic pain. In was concluded that there was a consensus that chronic pain clinical trials should assess outcomes representing six core domains: (1) pain, (2) physical functioning, (3) emotional functioning, (4) participant ratings of improvement and satisfaction with treatment, (5) symptoms and adverse events, (6) participant disposition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical trials
KW - chronic pain
KW - core outcome domains
KW - treatment effectiveness
KW - Initiatives on Methods Measurement and Pain Assessment in Clinical Trials
KW - 2003
KW - Chronic Pain
KW - Clinical Trials
KW - Treatment Effectiveness Evaluation
KW - Treatment Outcomes
KW - 2003
DO - 10.1016/j.pain.2003.08.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-11082-010&site=ehost-live&scope=site
UR - turkdc@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07531-006
AN - 2005-07531-006
AU - Hariri, A. R.
AU - Weinberger, D. R.
T1 - Functional neuroimaging of genetic variation in serotonergic neurotransmission.
JF - Genes, Brain & Behavior
JO - Genes, Brain & Behavior
JA - Genes Brain Behav
Y1 - 2003/12//
VL - 2
IS - 6
SP - 341
EP - 349
CY - United Kingdom
PB - Blackwell Publishing
SN - 1601-1848
SN - 1601-183X
AD - Hariri, A. R., Developmental Imaging Genomics Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, E-729, Pittsburgh, PA, US, 15213-2593
N1 - Accession Number: 2005-07531-006. PMID: 14653306 Partial author list: First Author & Affiliation: Hariri, A. R.; Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neuroimaging; Neurotransmission; Polymorphism; Serotonin; Behavioral Genetics. Classification: Neuropsychology & Neurology (2520). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2003.
AB - Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroimaging
KW - genetic variation
KW - serotonergic neurotransmission
KW - environmental cues
KW - polymorphism
KW - 2003
KW - Neuroimaging
KW - Neurotransmission
KW - Polymorphism
KW - Serotonin
KW - Behavioral Genetics
KW - 2003
DO - 10.1046/j.1601-1848.2003.00048.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07531-006&site=ehost-live&scope=site
UR - haririar@upmc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10326-006
AN - 2003-10326-006
AU - Snowden, Lonnie R.
T1 - Challenges to consensus in preparing the supplement to the Surgeon General's report on mental health.
T3 - The Politics of Science: Culture, race, ethnicity, and the Supplement to the Surgeon General's Report on Mental Health
JF - Culture, Medicine and Psychiatry
JO - Culture, Medicine and Psychiatry
JA - Cult Med Psychiatry
Y1 - 2003/12//
VL - 27
IS - 4
SP - 409
EP - 418
CY - Germany
PB - Springer
SN - 0165-005X
SN - 1573-076X
AD - Snowden, Lonnie R., Center for Mental Health Services Research, School of Social Welfare, Universtiy of California, 120 Haviland Hall 7400, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2003-10326-006. PMID: 14727677 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, School of Social Welfare, Universtiy of California, Berkeley, CA, US. Release Date: 20040816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ethnology; Mental Health; Minority Groups; Public Health; Racial and Ethnic Differences. Classification: Culture & Ethnology (2930). Population: Human (10). Location: US. Methodology: Empirical Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2003.
AB - Preparing the Supplement to the Surgeon General's Report on Mental Health proved controversial because the assignment, by its nature, challenged several forms of consensus that typically remain unexamined. They included disciplinary assumptions about theory and methods, sociopolitical assumptions about the relevance of history to contemporary circumstances of ethnic minority groups in America, the rigor and usefulness of cultural formulation, and whether the burden of proof rested with those who took for granted that sociocultural differences exist in theories of behavior, or those who took for granted the existence of universals. Preparation of the Supplement illustrates the uncertainty and tension that arise when unexamined boundaries and perspectives lose their capacity to serve as guides to scientific judgment and discourse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - culture
KW - ethnicity
KW - minority mental health
KW - race
KW - 2003
KW - Ethnology
KW - Mental Health
KW - Minority Groups
KW - Public Health
KW - Racial and Ethnic Differences
KW - 2003
DO - 10.1023/B:MEDI.0000005480.75504.4b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10326-006&site=ehost-live&scope=site
UR - snowden@unclink.berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10415-007
AN - 2003-10415-007
AU - Yu, Stella M.
AU - Huang, Zhihuan J.
AU - Schwalberg, Renee H.
AU - Overpeck, Mary
AU - Kogan, Michael D.
T1 - Acculturation and the health and well-being of U.S. immmigrant adolescents.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2003/12//
VL - 33
IS - 6
SP - 479
EP - 488
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Yu, Stella M., Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2003-10415-007. PMID: 14642710 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Yu, Stella M.; Maternal and Child Health Bureau, Office of Data and Information Management, Rockville, MD, US. Release Date: 20040712. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Acculturation; Adolescent Development; Health; Immigration; Well Being. Minor Descriptor: Education; Health Behavior; Language; Parents; Psychosocial Factors; Racial and Ethnic Groups; Risk Factors. Classification: Psychosocial & Personality Development (2840); Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2003.
AB - Examined the association of acculturation, as measured by language spoken at home, with the health, psychosocial, school, and parental risk factors of adolescents of various racial/ethnic groups. Using the US component of the 1997-98 World Health Organization Study of Health Behavior in School Children, bivariate and multiple logistic regression analyses were conducted of records for adolescents in four racial/ethnic groups to explore the relationship between the language spoken at home and outcome variables regarding health status and risks, psychosocial and school risk factors, and parental factors. Data were analyzed using Software for the Statistical Analysis of Correlated Data (SUDAAN). Those who speak a combination of languages are also at risk for being bullied and for high parental expectations. Language spoken at home is generally not associated with health and safety measures for adolescents across racial/ethnic groups. Adolescents whose primary language at home is not English experience higher psychosocial, school, and parental risks than non-Hispanic white English-speakers. New immigrant youths of all races and ethnic groups would potentially benefit from preventive and risk-reduction services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health
KW - well being
KW - immmigrant adolescents
KW - acculturation
KW - racial/ethnic groups
KW - parental factors
KW - sociocultural risk factors
KW - language spoken
KW - adolescent experience
KW - school
KW - 2003
KW - Acculturation
KW - Adolescent Development
KW - Health
KW - Immigration
KW - Well Being
KW - Education
KW - Health Behavior
KW - Language
KW - Parents
KW - Psychosocial Factors
KW - Racial and Ethnic Groups
KW - Risk Factors
KW - 2003
DO - 10.1016/S1054-139X(03)00210-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10415-007&site=ehost-live&scope=site
UR - syu@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-10800-006
AN - 2003-10800-006
AU - Knox, Kerry L.
AU - Litts, David A.
AU - Talcott, Wayne G.
AU - Feig, Jill Catalano
AU - Caine, Eric D.
T1 - Risk of suicide and related adverse outcomes after exposure to a suicide prevention programme in the US Air Force: Cohort study.
JF - BMJ: British Medical Journal
JO - BMJ: British Medical Journal
JA - BMJ
Y1 - 2003/12//
VL - 327
IS - 7428
SP - 1376
EP - 1378
CY - United Kingdom
PB - BMJ Publishing Group
SN - 0959-8138
SN - 1756-1833
AD - Knox, Kerry L., University of Rochester Center for the Study and Prevention of Suicide, University of Rochester Medical Center, Rochester, NY, US, 14642
N1 - Accession Number: 2003-10800-006. Partial author list: First Author & Affiliation: Knox, Kerry L.; University of Rochester Center for the Study and Prevention of Suicide, University of Rochester Medical Center, Rochester, NY, US. Release Date: 20040202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Air Force Personnel; Mental Health Programs; Program Evaluation; Risk Factors; Suicide Prevention. Minor Descriptor: Health Care Seeking Behavior. Classification: Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study. References Available: Y. Page Count: 3. Issue Publication Date: Dec, 2003.
AB - Evaluates the impact of the US Air Force suicide prevention programme on risk of suicide and other outcomes that share underlying risk factors. A cohort study with quasi-experimental design and analysis of cohorts before (1990-6) and after (1997-2002) the intervention was conducted. Ss were 5 260 292 US Air Force personnel (around 84% were men). The study used a multilayered intervention targeted at reducing risk factors and enhancing factors considered protective. The intervention consisted of removing the stigma of seeking help for a mental health or psychosocial problem, enhancing understanding of mental health, and changing policies and social norms. Implementation of the programme was associated with a sustained decline hi the rate of suicide and other adverse outcomes. A 33% relative risk reduction was observed for suicide after the intervention; reductions for other outcomes ranged from 18-54%. The study concluded that systemic intervention aimed at changing social norms about seeking help and incorporating training in suicide prevention has a considerable impact on promotion of mental health. The impact on adverse outcomes in addition to suicide strengthens the conclusion that the programme was responsible for these reductions in risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide risk
KW - suicide prevention program
KW - program success
KW - help seeking behavior
KW - Air Force
KW - stigma reduction
KW - mental health promotion
KW - 2003
KW - Air Force Personnel
KW - Mental Health Programs
KW - Program Evaluation
KW - Risk Factors
KW - Suicide Prevention
KW - Health Care Seeking Behavior
KW - 2003
DO - 10.1136/bmj.327.7428.1376
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-10800-006&site=ehost-live&scope=site
UR - Kerry_knox@urmc.rochester.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106757927
T1 - Setting dietary guidelines: the US process.
AU - McMurry KY
Y1 - 2003/12/02/Dec2003 Supplement 1
N1 - Accession Number: 106757927. Language: English. Entry Date: 20040723. Revision Date: 20150819. Publication Type: Journal Article; pictorial. Supplement Title: Dec2003 Supplement 1. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Health Promotion
KW - Food Guide Pyramid
KW - Nutrition
KW - Nutrition Policy -- Trends -- United States
KW - United States Department of Health and Human Services
KW - United States Department of Agriculture
KW - United States
SP - S10
EP - 6
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 103
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Senior Nutrition Advisor, US Department of Health and Human Services, Office of Public Health and Science, Office of Disease Prevention and Health Promotion, 200 Independence Avenue SW, Room 738G, Washington, DC 20201; kmcmurry@osophs.dhhs.gov
U2 - PMID: 14666494.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106757927&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106525829
T1 - Who's enrolled in the State Children's Health Insurance Program (SCHIP)? An overview of findings from the Child Health Insurance Research Initiative (CHIRI)
AU - Brach C
AU - Lewit EM
AU - VanLandeghem K
AU - Bronstein J
AU - Dick AW
AU - Kimminau KS
AU - LaClair B
AU - Shenkman E
AU - Shone LP
AU - Swigonski N
AU - Szilagyi PG
Y1 - 2003/12/02/Dec2003 Supplement
N1 - Accession Number: 106525829. Language: English. Entry Date: 20051014. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Dec2003 Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality (AL HS10435, FL HS10465, IN HS10453, KS HS10536, and NY HS10450), the David and Lucile Packard Foundation, the Health Resources and Services Administration, the Kansas Health Foundation, the United Methodist Health Ministry Fund, the Prime Health Foundation, and the University of Alabama at Birmingham from the Alabama Children's Health Insurance Program. NLM UID: 0376422.
KW - Child Health Services -- Utilization
KW - Insurance, Health -- Utilization -- In Infancy and Childhood
KW - State Health Plans -- Utilization -- In Infancy and Childhood
KW - Adolescence
KW - Child
KW - Child Health Services -- Trends
KW - Child, Disabled
KW - Funding Source
KW - Health Policy
KW - Insurance, Health -- Trends -- In Infancy and Childhood
KW - Minority Groups -- In Infancy and Childhood
KW - Multivariate Analysis
KW - Socioeconomic Factors
KW - State Health Plans -- Trends -- In Infancy and Childhood
KW - Surveys
KW - United States
KW - Human
SP - e499
EP - 507
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 112
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - BACKGROUND: The State Children's Health Insurance Program (SCHIP) was enacted in 1997 to provide health insurance coverage to uninsured low-income children from families who earned too much to be eligible for Medicaid. OBJECTIVES: To develop a 'baseline' portrait of SCHIP enrollees in 5 states (Alabama, Florida, Kansas, Indiana, and New York) by examining: 1) SCHIP enrollees' demographic characteristics and health care experiences before enrolling in SCHIP, particularly children with special health care needs (CSHCN), racial and ethnic minority children, and adolescents; 2) the quality of the care adolescents received before enrollment; and 3) the changes in enrollee characteristics as programs evolve and mature. METHODS: Each of 5 projects from the Child Health Insurance Research Initiative (CHIRI) surveyed new SCHIP enrollees as identified by state enrollment data. CHIRI investigators developed the CHIRI common core (a set of survey items from validated instruments), which were largely incorporated into each survey. Bivariate and multivariate analyses were conducted to ascertain whether there were racial and ethnic disparities in access to health care and differences between CSHCN and those without. Current Population Survey data for New York State were used to identify secular trends in enrollee characteristics. RESULTS: Most SCHIP enrollees (65% in Florida to 79% in New York) resided in families with incomes < or =150% of the federal poverty level. Almost half of SCHIP enrollees lived in single-parent households. A majority of SCHIP parents had not had education beyond high school, and in 2 states (Alabama and New York) approximately 25% had not completed high school. The vast majority of children lived in households with a working adult, and in a substantial proportion of households both parents worked. Children tended to be either insured for the entire 12 months or uninsured the entire 12 months before enrolling in SCHIP. Private insurance was the predominant form of insurance before enrollment in SCHIP in most states, but 23.3% to 51.2% of insured children had Medicaid as their most recent insurance. HEALTH CARE USE AND UNMET NEEDS BEFORE SCHIP: The vast majority of all SCHIP enrollees had a usual source of care (USC) during the year before SCHIP. The proportion of children who changed their USC after enrolling in SCHIP ranged from 29% to 41.3%. A large proportion of SCHIP enrollees used health services during the year before SCHIP, with some variability across states in the use of health care. Nevertheless, 32% to almost 50% of children reported unmet needs. CSHCN: The prevalence of CSHCN in SCHIP (between 17% and 25%) in the study states was higher than the prevalence of CSHCN reported in the general population in those states. In many respects, CSHCN were similar to children without special health care needs, but CSHCN had poorer health status, were more likely to have had unmet needs, and were more likely to use the emergency department, mental health care, specialty care, and acute care in the year before enrolling in SCHIP than children without special health care needs. RACE AND ETHNICITY: A substantial proportion of SCHIP enrollees were black non-Hispanic or Hispanic children (Alabama: 34% and <1%; Florida: 6% and 26%; Kansas: 12% and 15%; and New York: 31% and 45%, respectively). Minority children were poorer, in poorer health, and less likely to have had a USC or private insurance before enrolling in SCHIP. The prevalence and magnitude of the disparities varied among the states. QUALITY OF CARE FOR ADOLESCENTS: Seventy-three percent of adolescent SCHIP enrollees engaged in one or more risk behaviors (ie, feeling sad or blue; alcohol, tobacco, and drug use; having sexual intercourse; and not wearing seat belts). Although almost 70% of adolescents reported having had a preventive care visit the previous year, a majority of them did not receive counseling in each of 4 counseling areas. Controlling for other factors, having a private, confidential visit with the physician was associated with an increased liked likelihood (2-3 times more likely) that the adolescent received counseling for 3 of 4 counseling areas. TRENDS OVER TIME: New York SCHIP enrollees in 2001, compared with 1994 enrollees in New York's SCHIP-precursor child health insurance program, were more likely to be black or Hispanic, older, from New York City, and from families with lower education, income, and employment levels. A greater proportion of 2001 enrollees was uninsured for some time in the year before enrollment, was insured by Medicaid, and lacked a USC. Secular trends in the low-income population in the state did not seem to be responsible for these differences. Program modifications during this time period that may be related to the shift in enrollee characteristics include changes to benefits, outreach and marketing efforts, changes in the premium structure, and the advent of a single application form for multiple public programs. CONCLUSIONS: SCHIP enrollees are a diverse group, and there was considerable variation among the 5 study states. Overall, SCHIP enrollees had substantial and wide-ranging health care needs despite high levels of prior contact with the health care system. A sizable minority of SCHIP enrollees has special health care needs. There is racial and ethnic diversity in the composition of enrollees as well, with racial and ethnic disparities present. The quality of care adolescents received before enrollment in SCHIP was suboptimal, with many reporting unmet health care needs and not receiving recommended counseling. The characteristics of SCHIP enrollees can be expected to change as SCHIP programs evolve and mature. POLICY IMPLICATIONS: 1) Benefits should be structured to meet the needs of SCHIP enrollees, which are comparable to Medicaid enrollees' needs in many respects. 2) Provider networks will have to be broad if continuity of care is to be achieved. 3) Multiple outreach strategies should be used, including using providers to distribute information about SCHIP. 4) The quality of care delivered to vulnerable populations (eg, minority children, CSHCN, and adolescents) should be monitored. 5) States and health plans should actively promote quality health care with the goal of improving the care received by SCHIP enrollees before enrollment. 6) States will have to craft policies that fit their local context. 7) Collecting baseline information on SCHIP enrollees on a continuous basis is important, because enrollee characteristics and needs can change, and many vulnerable children are enrolling in SCHIP.
SN - 0031-4005
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; cbrach@ahrq.gov
U2 - PMID: 14654672.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106525829&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Glaser, LC
AU - Wegner, MV
AU - Davis, J.P.
AU - Bunning, M. L.
AU - Marfin, A. A.
AU - Campbell, G. L.
AU - Bernard, B.
AU - Lenhart, S.W.
T1 - West Nile Virus Infection Among Turkey Breeder Farm Workers—Wisconsin, 2002.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2003/12/03/
VL - 290
IS - 21
M3 - Article
SP - 2793
EP - 2796
SN - 00987484
AB - Discusses a 2002 West Nile Virus infection among turkey farm workers in Wisconsin. Wisconsin Department of Public Health investigation which revealed a high incidence of febrile illness; Indication of possible nonmosquito transmission among birds; Recommendations for preventive measures among workers.
KW - WEST Nile fever -- Transmission
KW - TURKEYS
KW - DISEASES
KW - BIRDS as carriers of disease
KW - PUBLIC health
KW - WISCONSIN
KW - UNITED States
KW - Disease Transmission, Zoonotic
KW - FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
KW - Occupational Exposure
KW - Turkeys
KW - West Nile virus
KW - Wisconsin
N1 - Accession Number: 11580994; Glaser, LC 1 Wegner, MV 1 Davis, J.P. 1 Bunning, M. L. 2 Marfin, A. A. 2 Campbell, G. L. 2 Bernard, B. 2 Lenhart, S.W. 3; Affiliation: 1: Div of Public Health, State of Wisconsin Dept of Health and Family Svcs 2: Division of VectorBorne Infectious Disease 3: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health; Source Info: 12/3/2003, Vol. 290 Issue 21, p2793; Subject Term: WEST Nile fever -- Transmission; Subject Term: TURKEYS; Subject Term: DISEASES; Subject Term: BIRDS as carriers of disease; Subject Term: PUBLIC health; Subject Term: WISCONSIN; Subject Term: UNITED States; Author-Supplied Keyword: Disease Transmission, Zoonotic; Author-Supplied Keyword: FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION; Author-Supplied Keyword: Occupational Exposure; Author-Supplied Keyword: Turkeys; Author-Supplied Keyword: West Nile virus; Author-Supplied Keyword: Wisconsin; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112330 Turkey Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11580994&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106756693
T1 - Organizing patient safety research to identify risks and hazards.
AU - Battles JB
AU - Lilford RJ
Y1 - 2003/12/03/
N1 - Accession Number: 106756693. Language: English. Entry Date: 20040716. Revision Date: 20150711. Publication Type: Journal Article; glossary; pictorial. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Patient Safety
KW - Risk Assessment
KW - Treatment Errors -- Prevention and Control
KW - Health Services Research
KW - Program Evaluation
KW - Research Methodology
KW - United States
SP - ii2
EP - 7
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - Patient safety has become an international priority with major research programmes being carried out in the USA, UK, and elsewhere. The challenge is how to organize research efforts that will produce the greatest yield in making health care safer for patients. Patient safety research initiatives can be considered in three different stages: (1) identification of the risks and hazards; (2) design, implementation, and evaluation of patient safety practices; and (3) maintaining vigilance to ensure that a safe environment continues and patient safety cultures remain in place. Clearly, different research methods and approaches are needed at each of the different stages of the continuum. A number of research approaches can be used at stage 1 to identify risks and hazards including the use of medical records and administrative record review, event reporting, direct observation, process mapping, focus groups, probabilistic risk assessment, and safety culture assessment. No single method can be universally applied to identify risks and hazards in patient safety. Rather, multiple approaches using combinations of these methods should be used to increase identification of risks and hazards of health care associated injury or harm to patients.
SN - 1475-3898
AD - Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, 540 Gaither Road, Rockville, MD 20850; jbattles@ahrq.gov
U2 - PMID: 14645888.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106756693&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106756700
T1 - Hindsight bias, outcome knowledge and adaptive learning.
AU - Henriksen K
AU - Kaplan H
Y1 - 2003/12/03/
N1 - Accession Number: 106756700. Language: English. Entry Date: 20040716. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Learning
KW - Treatment Errors -- Prevention and Control
KW - Adaptation, Psychological
KW - Bias (Research)
KW - Knowledge
KW - Memory
KW - Retrospective Design
KW - Treatment Errors -- Legislation and Jurisprudence -- United States
KW - Uncertainty
KW - United States
KW - Witness, Legal
SP - ii46
EP - 50
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - The ubiquitous nature of hindsight bias is a cause for concern for those engaged in investigations and retrospective analysis of medical error. Hindsight does not equal foresight. Investigations that are anchored to outcome knowledge run the risk of not capturing the complexities and uncertainties facing sharp end personnel and why their actions made sense at the time. Important lessons go unlearned if the exercise is simply to back track someone else's decision landmarks. Outcome knowledge can also bias our thinking on the quality of the processes that led to the outcome. This paper examines the influence of outcome knowledge in relation to reconstructive memory and legal testimony, ways for reducing the impact of outcome knowledge, and an adaptive learning framework that places hindsight bias in a broader context of rapid updating of knowledge.
SN - 1475-3898
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; khenriks@ahrq.gov
U2 - PMID: 14645895.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106756700&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106756702
T1 - Administrative data based patient safety research: a critical review.
AU - Zhan C
AU - Miller MR
Y1 - 2003/12/03/
N1 - Accession Number: 106756702. Language: English. Entry Date: 20040716. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Databases
KW - Health Services Research -- Methods
KW - Treatment Errors
KW - Epidemiological Research
KW - International Classification of Diseases
KW - Patient Safety
KW - Quality Assurance
KW - Reproducibility of Results
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - ii58
EP - 63
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - Administrative data are readily available, inexpensive, computer readable, and cover large populations. Despite coding irregularities and limited clinical details, administrative data supplemented by tools such as the Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs) could serve as a screen for potential patient safety problems that merit further investigation, offer valuable insights into adverse impacts and risks of medical errors and, to some extent, provide benchmarks for tracking progress in patient safety efforts at local, state, or national levels.
SN - 1475-3898
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20852; czhan@ahrq.gov
U2 - PMID: 14645897.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106756702&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sung, Kidon
AU - Khan, Saeed A.
AU - Nawaz, Mohamed S.
AU - Khan, Ashraf A.
T1 - A simple and efficient Triton X-100 boiling and chloroform extraction method of RNA isolation from Gram-positive and Gram-negative bacteria
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2003/12/05/
VL - 229
IS - 1
M3 - Article
SP - 97
SN - 03781097
AB - A fast, reliable, and inexpensive Triton X-100 boiling procedure for RNA isolation from both the Gram-positive and Gram-negative bacteria was developed. The yield of RNA was 0.2–2 mg per 10 ml bacterial culture. The method was tested on Gram-positive and Gram-negative bacteria of eight genera and nine species and yielded reproducible results. In parallel experiments, the Qiagen and hot phenol extraction methods both yielded RNA that contained contaminating 16S and 23S rRNA. The Triton X-100 boiling method reported here yielded RNA that was free from 16S and 23S rRNA, contained full-length transcripts and did not require additional purification. The presence of specific mRNA in one of the RNA samples obtained by this procedure was demonstrated by partial amplification of a 732 bp vancomycin resistance gene, vanA, by reverse transcription-polymerase chain reaction (RT-PCR). The presence of a full-length transcript (1031 bases) of the vanA gene was verified by Northern hybridization and probing with a digoxigenin (DIG)-labeled vanA PCR partial product. The method provides a rapid, reliable, and simple tool for the isolation of good quality RNA suitable for various molecular biology experiments. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Hybridization
KW - Gram-negative bacteria
KW - Gram-positive bacteria
KW - Electrophoresis
N1 - Accession Number: 11537696; Sung, Kidon 1; Khan, Saeed A.; Email Address: skhan@nctr.fda.gov; Nawaz, Mohamed S. 1; Khan, Ashraf A. 1; Affiliations: 1: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Dec2003, Vol. 229 Issue 1, p97; Thesaurus Term: RNA; Thesaurus Term: Hybridization; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Gram-positive bacteria; Author-Supplied Keyword: Electrophoresis; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0378-1097(03)00791-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11537696&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Williams, Lee D.
AU - Von Tungeln, Linda S.
AU - Beland, Frederick A.
AU - Doerge, Daniel R.
T1 - Liquid chromatographic–mass spectrometric determination of the metabolism and disposition of the anti-retroviral nucleoside analogs zidovudine and lamivudine in C57BL/6N and B6C3F1 mice
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2003/12/05/
VL - 798
IS - 1
M3 - Article
SP - 55
SN - 15700232
AB - Transmission of HIV from mother to infant can be effectively prevented by zidovudine (3′-azido-3′-deoxythymidine; AZT) alone or in combination with other anti-retroviral drugs; however, significant evidence for genotoxicity, including transplacental carcinogenicity in mice, has been reported for AZT. A method, based upon solid phase extraction (SPE) in the 96-well format, gradient liquid chromatography (LC), and electrospray mass spectrometry (MS), was developed and validated to measure serum concentrations in maternal C57BL/6N and fetal B6C3F1 mice of the nucleoside analogs AZT, lamivudine ((-)2′,3′-dideoxy-3′-thiacytidine; 3TC), and several metabolites selected based on importance in detoxification and bioactivation reactions. After intravenous (IV) and oral dosing with either 400 mg/kg AZT or 200 mg/kg 3TC, pharmacokinetics were determined for AZT, AZT-5′-glucuronide, 3′-amino-3′-deoxythymidine (AMT), AZT-5′-phosphate, 3TC, and 3TC-5′-phosphate in serum of adult female mice. Pharmacokinetics were also determined in spleen for AZT-5′-phosphate and 3TC-5′-phosphate following IV dosing. In addition, a preliminary assessment was made of placental transfer of AZT and 3TC and the presence of metabolites in the fetal compartment. The method described provides a means to evaluate thoroughly metabolism and disposition of anti-retroviral nucleoside analogs in maternal and fetal mice for comprehensive studies of genotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - AZT (Drug)
KW - SERUM
KW - MASS spectrometry
KW - Lamivudine
KW - Zidovudine
N1 - Accession Number: 11399928; Williams, Lee D. 1 Von Tungeln, Linda S. 1 Beland, Frederick A. 1 Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov; Affiliation: 1: Biochemical Toxicology Division, National Center for Toxicological Research, FDA, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Dec2003, Vol. 798 Issue 1, p55; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: AZT (Drug); Subject Term: SERUM; Subject Term: MASS spectrometry; Author-Supplied Keyword: Lamivudine; Author-Supplied Keyword: Zidovudine; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jchromb.2003.08.051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11399928&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Pitts, Peter J.
T1 - Ensuring Food Safety.
JO - New York Times
JF - New York Times
Y1 - 2003/12/08/
VL - 153
IS - 52691
M3 - Letter
SP - A28
EP - A28
SN - 03624331
AB - Presents a letter to the editor regarding the effort of the U.S. Food and Drug Administration to strengthen the safety of food supply.
KW - LETTERS to the editor
KW - FOOD supply
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 11915482; Pitts, Peter J. 1; Affiliation: 1: Associate commissioner for external relations of the Food and Drug Administration; Source Info: 12/8/2003, Vol. 153 Issue 52691, pA28; Subject Term: LETTERS to the editor; Subject Term: FOOD supply; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 1/9p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parsons, Barbara L.
T1 - MED1: A central molecule for maintenance of genome integrity and response to DNA damage.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2003/12/09/
VL - 100
IS - 25
M3 - Article
SP - 14601
EP - 14602
SN - 00278424
AB - Maintaining genome integrity is a dynamic process that involves many different cellular pathways, including methylation maintenance, homologous recombination, DNA replication, DNA repair, and cell cycle control. A defect in one or more of these pathways can compromise genome integrity and result in cancer. A number of DNA repair proteins have been identified that also impact the regulation of the cell cycle or apoptosis. Individuals carrying germ-line mutations in such genes are predisposed to develop cancer .
KW - GENOMES
KW - METHYLATION
KW - DNA
KW - CANCER -- Diagnosis
KW - CELL cycle
KW - APOPTOSIS
N1 - Accession Number: 12121132; Parsons, Barbara L. 1; Email Address: bparsons@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Texicological Research, United States Food and Drug Administration, Jefferson.; Source Info: 12/9/2003, Vol. 100 Issue 25, p14601; Subject Term: GENOMES; Subject Term: METHYLATION; Subject Term: DNA; Subject Term: CANCER -- Diagnosis; Subject Term: CELL cycle; Subject Term: APOPTOSIS; Number of Pages: 2p; Document Type: Article
L3 - 10.1073/pnas.2637169100
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12121132&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, Gabriel Keith
AU - Shi, Xianglin
T1 - Signaling by carcinogenic metals and metal-induced reactive oxygen species
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2003/12/10/
VL - 533
IS - 1/2
M3 - Article
SP - 183
SN - 00275107
AB - Epidemiological data indicate that exposure to metal and metalloid species, including arsenic(III), chromium(VI), and nickel(II), increases the risk of cancer, particularly of the lung and skin. Alterations in normal signal transduction as a result of exposure to carcinogenic metals, and to metal-catalyzed reactive oxygen species (ROS) formation, appear to play an important role in the etiology of metal-induced carcinogenesis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur, and the role of those changes in carcinogenesis are discussed. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALS
KW - SEMIMETALS
KW - CARCINOGENS
KW - ACTIVE oxygen
KW - activator protein-1 (AP-1)
KW - ataxia-telangiectasia mutated (ATM)
KW - ATM and Rad3-related (ATR)
KW - big MAPK-1 (BMAPK-1)
KW - c-jun-NH2-terminal kinase (JNK)
KW - epidermal growth factor (EGF)
KW - extracellular-regulated kinase (ERK)
KW - gene arrest and DNA damage (GADD)
KW - heme-oxygenase-1 (HO-1)
KW - hypoxia inducible factor-1 (HIF-1)
KW - interleukin (IL)
KW - MAPK/ERK kinase (MEK)
KW - Metals
KW - mitogen activated protein kinase (MAPK)
KW - nuclear factor of activated T cells (NFAT)
KW - nuclear transcription factor-kappa B (NFκB)
KW - platelet-derived growth factor (PDGF)
KW - Reactive oxygen species
KW - reactive oxygen species (ROS)
KW - reduced glutathione (GSH)
KW - reduced nicotine adenine dinucleotide phosphate (NADPH)
KW - Signal transduction
KW - superoxide dismutase (SOD)
KW - tumor necrosis factor (TNF)
KW - vascular endothelial growth factor (VEGF)
N1 - Accession Number: 11468360; Harris, Gabriel Keith; Email Address: gharris1@cdc.gov Shi, Xianglin 1; Affiliation: 1: National Research Council Associate, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd. (M/S 2015), Morgantown, WV 26505-2888, USA; Source Info: Dec2003, Vol. 533 Issue 1/2, p183; Subject Term: METALS; Subject Term: SEMIMETALS; Subject Term: CARCINOGENS; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: activator protein-1 (AP-1); Author-Supplied Keyword: ataxia-telangiectasia mutated (ATM); Author-Supplied Keyword: ATM and Rad3-related (ATR); Author-Supplied Keyword: big MAPK-1 (BMAPK-1); Author-Supplied Keyword: c-jun-NH2-terminal kinase (JNK); Author-Supplied Keyword: epidermal growth factor (EGF); Author-Supplied Keyword: extracellular-regulated kinase (ERK); Author-Supplied Keyword: gene arrest and DNA damage (GADD); Author-Supplied Keyword: heme-oxygenase-1 (HO-1); Author-Supplied Keyword: hypoxia inducible factor-1 (HIF-1); Author-Supplied Keyword: interleukin (IL); Author-Supplied Keyword: MAPK/ERK kinase (MEK); Author-Supplied Keyword: Metals; Author-Supplied Keyword: mitogen activated protein kinase (MAPK); Author-Supplied Keyword: nuclear factor of activated T cells (NFAT); Author-Supplied Keyword: nuclear transcription factor-kappa B (NFκB); Author-Supplied Keyword: platelet-derived growth factor (PDGF); Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: reduced glutathione (GSH); Author-Supplied Keyword: reduced nicotine adenine dinucleotide phosphate (NADPH); Author-Supplied Keyword: Signal transduction; Author-Supplied Keyword: superoxide dismutase (SOD); Author-Supplied Keyword: tumor necrosis factor (TNF); Author-Supplied Keyword: vascular endothelial growth factor (VEGF); NAICS/Industry Codes: 332811 Metal Heat Treating; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.08.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11468360&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Kim, Cheong-Sik
AU - Park, Soyeon
AU - Han, Soon Young
AU - Pyo, Myoung-Yun
AU - Yang, Mihi
T1 - Gender differences in the levels of bisphenol A metabolites in urine
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2003/12/12/
VL - 312
IS - 2
M3 - Article
SP - 441
SN - 0006291X
AB - The metabolism of bisphenol A (BPA), a suspected endocrine disruptor, should be considered for monitoring human exposure to BPA, because the conjugation with β-d-glucuronide and sulfate reduces the estrogenic activity. In this study, BPA levels in 30 healthy Koreans (men, N=15 , 42.6 ± 2.4 years; women, N=15 , 43.0 ± 2.7 years) were analyzed from urine treated with/without β-glucuronidase and/or sulfatase by an RP-HPLC with fluorescence detection. The total BPA concentrations including free BPA and the urinary conjugates were similar in men and women (2.82 ± 0.73 and 2.76 ± 0.54 ng ml−1, respectively), but gender differences were found in the levels of urinary BPA conjugates. Men had significantly higher levels of BPA–glucuronide (2.34 ± 0.85 ng ml−1) than women (1.00 ± 0.34 ng ml−1), whereas women had higher levels of BPA–sulfate (1.20 ± 0.32 ng ml−1) than men (0.49 ± 0.27 ng ml−1). [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - MONOMERS
KW - ENDOCRINOLOGY
KW - ESTROGEN
KW - β
KW - -Glucuronidase
KW - Bisphenol A
KW - Endocrine disruptor
KW - Sulfatase
KW - Urinary conjugates
N1 - Accession Number: 11399113; Kim, Yong-Hak 1 Kim, Cheong-Sik 1 Park, Soyeon 1 Han, Soon Young 2 Pyo, Myoung-Yun 3 Yang, Mihi 1,4; Email Address: myang@snu.ac.kr; Affiliation: 1: Department of Preventive Medicine, School of Medicine, Seoul-National University, 28 Yon-gun Dong, Chong-no Gu, Seoul 110-799, Republic of Korea 2: Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Republic of Korea 3: Department of Pharmacy, Sookmyung Women’s University, Chungpa-Dong, Yongsan-Ku, Seoul 140-742, Republic of Korea 4: Cancer Research Institute, School of Medicine, Seoul-National University, 28 Yon-gun Dong, Chong-no Gu, Seoul 110-799, Republic of Korea; Source Info: Dec2003, Vol. 312 Issue 2, p441; Subject Term: METABOLISM; Subject Term: MONOMERS; Subject Term: ENDOCRINOLOGY; Subject Term: ESTROGEN; Author-Supplied Keyword: β; Author-Supplied Keyword: -Glucuronidase; Author-Supplied Keyword: Bisphenol A; Author-Supplied Keyword: Endocrine disruptor; Author-Supplied Keyword: Sulfatase; Author-Supplied Keyword: Urinary conjugates; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.bbrc.2003.10.135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11399113&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hashemi, Ray R.
AU - Young, John F.
T1 - The Prediction of Methylmercury Elimination Half-Life in Humans using Animal Data: A Neural Network/Rough Sets Analysis.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2003/12/12/
VL - 66
IS - 23
M3 - Article
SP - 2227
SN - 15287394
AB - Artificial neural networks and Rough Sets methodology have been utilized to predict human pharmacokinetic elimination half-life data based on animal data training sets. Methylmercury (Hg) pharmacokinetic data was obtained from 37 literature references, which provided data on species, gender, age, weight, route of administration, dose, dose frequency, and elimination half-life based on either whole-body Hg analysis or blood Hg analysis. Data were categorized into various formats for analysis comparisons. Rough Sets methodology was utilized to identify and remove redundant independent variables. Artificial neural networks were used to produce models based on the animal data, which were in turn used to predict and compare to the human elimination half-life values. These neural network predictions were compared to allometric graphical plots of the same data. The best artificial neural network prediction was based on a "thermometer" categorical representation of the data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - ANIMAL models in research
KW - NEURAL networks (Computer science)
KW - METHODOLOGY
N1 - Accession Number: 11351865; Hashemi, Ray R. 1 Young, John F. 2; Email Address: jyoung@nctr.fda.gov; Affiliation: 1: Department of Computer Science, Armstrong Atlantic State University, Savannah, Jefferson, Arkansas, USA 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: 2003, Vol. 66 Issue 23, p2227; Subject Term: PHARMACOKINETICS; Subject Term: ANIMAL models in research; Subject Term: NEURAL networks (Computer science); Subject Term: METHODOLOGY; Number of Pages: 26p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Farrell, Gerard M.
AU - Lawrence, Arthur J.
T1 - Changes to Public Health Service Commissioned Corps.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2003/12/15/
VL - 60
IS - 24
M3 - Letter
SP - 2606
EP - 2607
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Presents several letters to the editor, about activities of the U.S. Department of Health and Human Services, published in the December 15, 2003 issue of the journal "American Journal of Health-System Pharmacy." Changes proposed to the Public Health Service Commissioned Corps; Role of pharmacists in the success of the anthrax prophylaxis campaign.
KW - LETTERS to the editor
KW - MEDICAL policy
KW - ANTHRAX -- Prevention
KW - PHARMACISTS -- United States
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 11611882; Farrell, Gerard M. 1 Lawrence, Arthur J. 2; Affiliation: 1: Captain. U.S. Navy (Ret.) Executive Director Commissioned Officers Association of the U.S. Public Health Service 8201 Corporate Drive, Suite 560 Landover, MD 20785. 2: Assistant Surgeon General and Deputy Assistant Secretary for Health (Operations) Department of Health and Human Services 716G 200 Independence Avenue. S.W. Washington, DC 20201.; Source Info: 12/15/2003, Vol. 60 Issue 24, p2606; Subject Term: LETTERS to the editor; Subject Term: MEDICAL policy; Subject Term: ANTHRAX -- Prevention; Subject Term: PHARMACISTS -- United States; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fu, Xin
AU - Blaydes, Betty S.
AU - Weis, Constance C.
AU - Latendresse, John R.
AU - Muskhelishvili, Levan
AU - Sutter, Thomas R.
AU - Delclos, K. Barry
T1 - Effects of dietary soy and estrous cycle on adrenal cytochrome P450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague–Dawley rats
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2003/12/15/
VL - 146
IS - 3
M3 - Article
SP - 273
SN - 00092797
AB - Cytochrome P450 1B1 (CYP1B1) has been shown to be important in the bioactivation of 7,12-dimethylbenz[a]anthracene (DMBA) to an adrenal toxin in rats. We investigated the effects of diet and stage of estrous cycle on CYP1B1 expression in rat adrenal glands and on DMBA metabolism by rat adrenal and hepatic microsomes. Female Sprague–Dawley (SD) rats were placed on either standard soy-containing NIH-31 rat chow or soy- and alfalfa-free 5K96 diet from postnatal day (PND) 21 until sacrifice at PND50±5 . Stage of estrous at sacrifice was assessed by vaginal cytology and confirmed by histological examination of the vagina. Dietary soy at the level present in NIH-31 diet did not affect serum estrogen and progesterone levels.Immunohistochemical analysis confirmed that CYP1B1 was exclusively expressed in the zona fasciculata and zona reticularis in adrenal cortex, which are the regions vulnerable to DMBA-induced adrenal necrosis. Adrenal CYP1B1 protein expression, 3H -DMBA depletion, and formation of DMBA-3,4-, and -8,9-dihydrodiols by adrenal microsomes were greater in animals fed 5K96 diet, and the stage of the estrous cycle affected these parameters only in the soy-free 5K96 diet. In hepatic microsomes, the formation of DMBA-3,4-dihydrodiol, 7-hydroxy- and 12-hydroxy-DMBA were lower in animals fed NIH-31 diet than in those fed 5K96 diet. Thus, dietary soy and the estrous cycle appear to regulate adrenal CYP1B1 expression and DMBA metabolism by both adrenal and hepatic microsomes. The use of different basal diets containing variable levels of soy components may affect certain toxicity assessments. [Copyright &y& Elsevier]
AB - Copyright of Chemico-Biological Interactions is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - BIOTRANSFORMATION (Metabolism)
KW - TOXINS
KW - ADRENAL glands
KW - Adrenal gland
KW - CYP1B1
KW - DMBA
KW - Estrous cycle
KW - Metabolism
KW - Soy
N1 - Accession Number: 11466959; Fu, Xin 1 Blaydes, Betty S. 1 Weis, Constance C. 1 Latendresse, John R. 2 Muskhelishvili, Levan 2 Sutter, Thomas R. 3 Delclos, K. Barry 1; Email Address: bdelclos@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA 2: Pathology Associates International Inc., Jefferson, AR 72079, USA 3: W. Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN 38152, USA; Source Info: Dec2003, Vol. 146 Issue 3, p273; Subject Term: CYTOCHROME P-450; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: TOXINS; Subject Term: ADRENAL glands; Author-Supplied Keyword: Adrenal gland; Author-Supplied Keyword: CYP1B1; Author-Supplied Keyword: DMBA; Author-Supplied Keyword: Estrous cycle; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Soy; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.cbi.2003.09.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11466959&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sivapalasingam, Sumathi
AU - Barrett, E.
AU - Kimura, A.
AU - Van Duyne, S.
AU - De Witt, W.
AU - Ying, M.
AU - Frisch, A.
AU - Phan, Q.
AU - Gould, E.
AU - Shillam, P.
AU - Reddy, V.
AU - Cooper, T.
AU - Hoekstra, M.
AU - Higgins, C.
AU - Sanders, J. P.
AU - Tauxe, R. V.
AU - Slutsker, L.
T1 - A Multistate Outbreak of Salmonella enterica Serotype Newport Infection Linked to Mango Consumption: Impact of Water-Dip Disinfestation Technology.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2003/12/15/
VL - 37
IS - 12
M3 - Article
SP - 1585
EP - 1590
SN - 10584838
AB - Fresh produce increasingly is recognized as an important source of salmonellosis in the United States. In December 1999, the Centers for Disease Control and Prevention detected a nationwide increase in Salmonella serotype Newport (SN) infections that had occurred during the previous month. SN isolates recovered from patients in this cluster had indistinguishable pulsed-field gel electrophoresis (PFGE) patterns (which identified the outbreak strain), suggesting a common source. Seventy-eight patients from 13 states were infected with the outbreak strain. Fifteen patients were hospitalized; 2 died. Among 28 patients enrolled in the matched case-control study, 14 (50%) reported they ate mangoes in the 5 days before illness onset, compared with 4 (10%) of the control subjects during the same period (matched odds ratio, 21.6; 95% confidence interval, 3.53-∞ P = .0001). Traceback of the implicated mangoes led to a single Brazilian farm, where we identified hot water treatment as a possible point of contamination; this is a relatively new process to prevent importation of an agricultural pest, the Mediterranean fruit fly. This is the first reported outbreak of salmonellosis implicating mangoes. PFGE was critical to the timely recognition of this nationwide outbreak. This outbreak highlights the potential global health impact of foodborne diseases and newly implemented food processes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Communicable diseases
KW - Bacteria
KW - Food poisoning
KW - Gel electrophoresis
N1 - Accession Number: 11768975; Sivapalasingam, Sumathi 1,2; Barrett, E. 3; Kimura, A. 4; Van Duyne, S. 1; De Witt, W. 1; Ying, M. 1; Frisch, A. 1; Phan, Q. 5; Gould, E. 6; Shillam, P. 7; Reddy, V. 8; Cooper, T. 9; Hoekstra, M. 10; Higgins, C. 1; Sanders, J. P. 11; Tauxe, R. V. 1; Email Address: rvt@cdc.gov; Slutsker, L. 1; Affiliations: 1: Foodborne and Diarrheal Diseases Branch, National Center for Infectious Diseases, National Center for Environmental Health.; 2: Epidemic Intelligence Service, Epidemiology Program Office.; 3: Virginia Department of Health, Richmond.; 4: California Department of Health Services, Gardena.; 5: Connecticut Department of Health, Hartford.; 6: Massachusetts Department of Health, Jamaica Plain.; 7: Colorado Department of Health, Denver.; 8: New York City Department of Health and Mental Hygiene, New York.; 9: Rhode Island Department of Health, Providence.; 10: Biostatistics and Information Management Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.; 11: US Food and Drug Administration, Rockville, Maryland.; Issue Info: 12/15/2003, Vol. 37 Issue 12, p1585; Thesaurus Term: Foodborne diseases; Thesaurus Term: Communicable diseases; Thesaurus Term: Bacteria; Thesaurus Term: Food poisoning; Subject Term: Gel electrophoresis; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mathew, Alan G.
AU - Arnett, Debbie B.
AU - Cullen, Patricia
AU - Ebner, Paul D.
T1 - Characterization of resistance patterns and detection of apramycin resistance genes in Escherichia coli isolated from swine exposed to various environmental conditions
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2003/12/15/
VL - 89
IS - 1
M3 - Article
SP - 11
SN - 01681605
AB - Weaned pigs were separated into eight treatments including a control without exposure to apramycin; a control with exposure to apramycin; and apramycin plus either cold stress, heat stress, overcrowding, intermingling, poor sanitation, or intervention with oxytetracycline, to determine the effects of management and environmental conditions on antibiotic resistance among indigenous Escherichia coli. Pigs exposed to apramycin sulfate received that antibiotic in the feed at a concentration of 150 g/ton for 14 days. Environmental treatments were applied 5 days following initial antibiotic administration and maintained throughout the study. Fecal samples were obtained on day 0 (prior to antibiotic treatment) and on days 2, 7, 14, 28, 64, 148, and 149. E. coli were isolated and tested for resistance to apramycin using a minimum inhibitory concentration (MIC) broth microdilution method. Macrorestriction profiling, arbitrarily primed PCR, PCR targeting a gene coding for apramycin resistance, and DNA hybridization were used to characterize genetic elements of resistance. Increased (P<0.0001) resistance to apramycin was noted in E. coli from all treatment groups administered apramycin. MICs of isolates from control pigs receiving apramycin returned to pretreatment levels following removal of the antibiotic, whereas isolates from cold stress, overcrowding, and oxytetracycline groups expressed greater (P<0.05) MICs through day 64, before returning to pretreatment levels. Genetic analysis indicated that all resistant isolates carried the aac(3)IV gene sequence and this sequence was found in a variety of E. coli isotypes. Our data indicate that E. coli resistance to apramycin is increased upon exposure to various stressors. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs
KW - Stress (Psychology)
KW - Cold (Temperature) -- Physiological effect
KW - Heat -- Physiological effect
KW - Antibiotic resistance
KW - Apramycin
KW - Escherichia coli
KW - Stress
KW - Swine
N1 - Accession Number: 11174256; Mathew, Alan G. 1; Email Address: amathew@utk.edu; Arnett, Debbie B. 2; Cullen, Patricia 3; Ebner, Paul D. 4; Affiliations: 1: Department of Animal Science, University of Tennessee, 2505 River Drive, Knoxville, TN 37996, USA; 2: Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831, USA; 3: Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; 4: LSU Health Sciences Center, 1501 Kings Hwy., Shreveport, LA 71130, USA; Issue Info: Dec2003, Vol. 89 Issue 1, p11; Thesaurus Term: Drugs; Subject Term: Stress (Psychology); Subject Term: Cold (Temperature) -- Physiological effect; Subject Term: Heat -- Physiological effect; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: Apramycin; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Stress; Author-Supplied Keyword: Swine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0168-1605(03)00124-7
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - prince, Gregory A.
AU - Mond, James J.
AU - Porter, David D.
AU - Yim, Kevin C.
AU - Lan, Steve J.
AU - Klinman, Dennis M.
T1 - Immunoprotective Activity and Safety of a Respiratory Syncytial Virus Vaccine: Mucosal Delivery of Fusion Glycoprotein with a CpG Oligodeoxynucleotide Adjuvant.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2003/12/15/
VL - 77
IS - 24
M3 - Article
SP - 13156
EP - 13160
SN - 0022538X
AB - CpG oligodeoxynucleotides (ODN) were identified that stimulated immunoglobulin production and cell proliferation in cotton rat cells in vitro. Three of these ODN were used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory syncytial virus fusion (F) protein. The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to respiratory syncytial virus. Such immunized animals had a marked reduction in the production of infectious virus after a live-virus challenge. Animals immunized with the combination of F protein and CpG developed enhanced pulmonary pathology consisting of alveolitis and interstitial pneumonitis after a live-virus challenge. Similar enhanced disease has been seen in cotton rats and children immunized with formalin-inactivated respiratory syncytial virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - CELL proliferation
KW - VIRUSES
KW - VIROLOGY
N1 - Accession Number: 11856323; prince, Gregory A. 1; Email Address: gprince@erols.com Mond, James J. 2 Porter, David D. 3 Yim, Kevin C. 1 Lan, Steve J. 1 Klinman, Dennis M. 4; Affiliation: 1: Virion Systems, Inc., Maryland 2: Biosynexus Inc., Gaithersburg, Maryland 3: Department of Pathology and Laboratory Medicine, University of California School of Medicine, California 4: Section of Retroviral Immunology, Center for Biologics Evaluaation and Research, Food and Drug Administration, Maryland; Source Info: Dec2003, Vol. 77 Issue 24, p13156; Subject Term: IMMUNOGLOBULINS; Subject Term: CELL proliferation; Subject Term: VIRUSES; Subject Term: VIROLOGY; Number of Pages: 5p; Illustrations: 3 Black and White Photographs, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Misra, Neeraj
AU - Singh, Harshinder
AU - James Harner, E.
T1 - Stochastic comparisons of Poisson and binomial random variables with their mixtures
JO - Statistics & Probability Letters
JF - Statistics & Probability Letters
Y1 - 2003/12/15/
VL - 65
IS - 4
M3 - Article
SP - 279
SN - 01677152
AB - Motivated by an ecological sampling problem, we compare a Poisson distribution having a fixed mean with a Poisson distribution having a random mean, which has an arbitrary continuous (or discrete) probability distribution. These comparisons are made with respect to the likelihood ratio ordering, simple stochastic ordering, uniform variability ordering and expectation ordering. As a particular case, the mixed Poisson and the Poisson distribution with a fixed mean are compared when both the distributions have the same mean. Similar comparisons are made between the mixed binomial and the binomial distribution having a fixed probability of success. [Copyright &y& Elsevier]
AB - Copyright of Statistics & Probability Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ECOLOGY
KW - SAMPLING (Statistics)
KW - POISSON distribution
KW - RANDOM measures
KW - 62N05
KW - Convex ordering
KW - Expectation ordering
KW - Likelihood ratio ordering
KW - Mixed binomial distribution
KW - Mixed Poisson distribution
KW - Simple stochastic ordering
KW - Uniformly more variable ordering
N1 - Accession Number: 11607274; Misra, Neeraj 1,2 Singh, Harshinder 1,3 James Harner, E. 1; Affiliation: 1: Department of Statistics, West Virginia University, PO Box 6330, Morgantown, WV 26506-6330, USA 2: Department of Mathematics, Indian Institute of Technology Kanpur, Kanpur 208 016, India 3: Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA; Source Info: Dec2003, Vol. 65 Issue 4, p279; Subject Term: ECOLOGY; Subject Term: SAMPLING (Statistics); Subject Term: POISSON distribution; Subject Term: RANDOM measures; Author-Supplied Keyword: 62N05; Author-Supplied Keyword: Convex ordering; Author-Supplied Keyword: Expectation ordering; Author-Supplied Keyword: Likelihood ratio ordering; Author-Supplied Keyword: Mixed binomial distribution; Author-Supplied Keyword: Mixed Poisson distribution; Author-Supplied Keyword: Simple stochastic ordering; Author-Supplied Keyword: Uniformly more variable ordering; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.spl.2003.07.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Eric W.
AU - Mammel, Mark K.
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Limited boundaries for extensive horizontal gene transfer among Salmonella pathogens.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2003/12/23/
VL - 100
IS - 26
M3 - Article
SP - 15676
EP - 15681
SN - 00278424
AB - Recombination is thought to be rare within Salmonella, as evidenced by absence of gene transfer among SARC strains that represent the broad genetic diversity of the eight primary subspecies of this common facultative intracellular pathogen. We adopted a phylogenetic approach to assess recombination within the routs gene of 70 SARB strains, a genetically homogeneous population of Salmonella enterica subspecies I strains, which have in common the ability to infect warm-blooded animals. We report here that SARB strains show evidence for widespread recombinational exchange in contrast to results obtained with strains exhibiting species-level genetic variation. Besides extensive allele shuffling, SARB strains showed notably larger recombinagenic patch sizes for routs (at least ≈ 1.1 kb) than previously reported for S. enterica SARC strains. Explaining these experimental dichotomies provides important insight for understanding microbial evolution, because they suggest likely ecologic and genetic barriers that limit extensive gene transfer in the feral setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - PATHOGENIC microorganisms
KW - GENETIC transformation
KW - PHYLOGENY
KW - MICROBIAL evolution
KW - BIOLOGY -- Classification
KW - SPECIES
KW - INTRACELLULAR pathogens
N1 - Accession Number: 12109960; Brown, Eric W. 1 Mammel, Mark K. 1 LeClerc, J. Eugene 1 Cebula, Thomas A. 1; Email Address: tcebula@cfsan.fda.gov; Affiliation: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for food Safety and Applied Nutrition, Food and Drug Administration, Laurel.; Source Info: 12/23/2003, Vol. 100 Issue 26, p15676; Subject Term: SALMONELLA; Subject Term: PATHOGENIC microorganisms; Subject Term: GENETIC transformation; Subject Term: PHYLOGENY; Subject Term: MICROBIAL evolution; Subject Term: BIOLOGY -- Classification; Subject Term: SPECIES; Subject Term: INTRACELLULAR pathogens; Number of Pages: 6p; Document Type: Article
L3 - 10 10.1073/pnas.2634406100
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chmielewski, Marcin K.
AU - Marchán, Vicente
AU - Cieślak, Jacek
AU - Grajkowski, Andrzej
AU - Livengood, Victor
AU - Münch, Ursula
AU - Wilk, Andrzej
AU - Beaucage, Serge L.
T1 - Thermolytic Carbonates for Potential 5'-Hydroxyl Protection of Deoxyribonucleosides.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2003/12/26/
VL - 68
IS - 26
M3 - Article
SP - 10003
EP - 10012
SN - 00223263
AB - Thermolytic groups structurally related to well-studied heat-sensitive phosphate/thiophosphate protecting groups have been evaluated for 5'-hydroxyl protection of deoxyribonucleosides as carbonates and for potential use in solid-phase oligonucleotide synthesis. The spatial arrangement of selected functional groups forming an asymmetric nucleosidic 5'-O-carbonic acid ester has been designed to enable heat-induced cyclodecarbonation reactions, which would result in the release of carbon dioxide and the generation of a nucleosidic 5'-hydroxyl group. The nucleosidic 5'-O-carbonates 3-8, 10-15, and 19-21 were prepared and were isolated in yields ranging from 45 to 83%. Thermolytic deprotection of these carbonates is preferably performed in aqueous organic solvent at 90 °C under near neutral conditions. The rates of carbonate deprotection are dependent on the nucleophilicity of the functional group involved in the postulated cyclodecarbonation reaction and on solvent polarity. Deprotection kinetics increase according to the following order: 4 < 5 < 10 < 6 < 12 < 7 < 13 < 8 < 14 ≅ 19-21 and CCl[sub 4] < dioxane < MeCN < t-BuOH < MeCN:phosphate buffer (3:1 v/v, pH 7.0) < EtOH:phosphate buffer (1:1 v/v, pH 7.0). Complete thermolytic deprotection of carbonates 7, 8, 13, and 14 is achieved within 20 min to 2 h under optimal conditions in phosphate buffer-MeCN. The 2-(2-pyridyl)amino-1-phenylethyl and 2-[N-methyl-N-(2-pyridyl)]aminoethyl groups are particularly promising for 5'-hydroxyl protection of deoxyribonucleosides as thermolytic carbonates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATES
KW - CARBONATES
KW - OLIGONUCLEOTIDES
KW - NUCLEOTIDES
KW - DEOXYRIBONUCLEOTIDES
KW - HYDROXYL group
N1 - Accession Number: 11963601; Chmielewski, Marcin K. 1 Marchán, Vicente 1 Cieślak, Jacek 1 Grajkowski, Andrzej 1 Livengood, Victor 1 Münch, Ursula 1 Wilk, Andrzej 1 Beaucage, Serge L. 1; Email Address: beaucage@cber.fda.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland and Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland; Source Info: 12/26/2003, Vol. 68 Issue 26, p10003; Subject Term: PHOSPHATES; Subject Term: CARBONATES; Subject Term: OLIGONUCLEOTIDES; Subject Term: NUCLEOTIDES; Subject Term: DEOXYRIBONUCLEOTIDES; Subject Term: HYDROXYL group; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cieślak, Jacek
AU - Beaucage, Serge L.
T1 - Thermolytic Properties of 3-(2-Pyridyl)-1-propyl and 2-[N-Methyl-N-(2-pyridyl)aminoethyl Phosphate/Thiophosphate Protecting Groups in Solid-Phase Synthesis of Oligodeoxyribonucleotides.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2003/12/26/
VL - 68
IS - 26
M3 - Article
SP - 10123
EP - 10129
SN - 00223263
AB - Thermolytic groups may serve as alternatives to the conventional 2-cyanoethyl group for phosphate/ thiophosphate protection in solid-phase oligonucleotide synthesis to prevent DNA alkylation by acrylonitrile generated under the basic conditions used for oligonucleotide deprotection. Additionally, thermolytic groups are attractive in the context of engineering a "heat-driven" process for the synthesis of oligonucleotides on diagnostic microarrays. In these regards, the potential application of pyridine derivatives as thermolytic phosphate/thiophosphate protecting groups has been investigated. Specifically, 2-pyridinepropanol and 2-[N-methyl-N-(2-pyridyl)]aminoethanol were incorporated into deoxyribonucleoside phosphoramidites 7a-d and 9, which were found as efficient as 2-cyanoethyl deoxyribonucleoside phosphoramidites in solid-phase oligonucleotide synthesis. Whereas the removal of 3-(2-pyridyl)-1-propyl phosphate/thiophosphate protecting groups from oligonucleotides is effected within 30 min upon heating at 55 °C in concentrated NH[sub 4]OH or in an aqueous buffer at pH 7.0, cleavage of 2-[N-methyl-N-(2-pyridyl)]aminoethyl groups occurs spontaneously when their phosphate or phosphorothioate esters are formed during oligonucleotide synthesis. The deprotection of these groups follows a cyclodeesterification process generating the bicyclic salts 13 and 14 as side products. These salts do not alkylate or otherwise modify any DNA nucleobases and do not desulfurize a phosphorothioate diester model under conditions mimicking large-scale oligonucleotide deprotection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATES
KW - THIOPHOSPHATES
KW - DEOXYRIBONUCLEOTIDES
KW - OLIGONUCLEOTIDES
KW - NUCLEIC acids
KW - ORGANIC chemistry
N1 - Accession Number: 11963616; Cieślak, Jacek 1 Beaucage, Serge L. 1; Email Address: beaucage@cber.fda.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Biologie Evaluation and Research Food and Drug Administration, Maryland; Source Info: 12/26/2003, Vol. 68 Issue 26, p10123; Subject Term: PHOSPHATES; Subject Term: THIOPHOSPHATES; Subject Term: DEOXYRIBONUCLEOTIDES; Subject Term: OLIGONUCLEOTIDES; Subject Term: NUCLEIC acids; Subject Term: ORGANIC chemistry; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 2 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zuo-Hui Shao
AU - Vanden Hoek, Terry L.
AU - Chang-Qing Li
AU - Schumacker, Paul T.
AU - Becker, Lance B.
AU - Kim Chai Chan
AU - Yimin Qin
AU - Jun-Jie Yin
AU - Chun-Su Yuan
T1 - Synergistic Effect of Scutellaria baicalensis and Grape Seed Proanthocyanidins on Scavenging Reactive Oxygen Species in Vitro.
JO - American Journal of Chinese Medicine
JF - American Journal of Chinese Medicine
Y1 - 2004/01//
VL - 32
IS - 1
M3 - Article
SP - 89
EP - 95
PB - World Scientific Publishing Company
SN - 0192415X
AB - Scutellaria baicalensis (SbE) is a commonly used Chinese herb medicine and grape seed proanthocyanidins is a popular herbal supplement in the United States. Both herbs have been shown to possess potent antioxidant effects. Using an in vitro model to produce the reactive oxygen species (ROS) generation (H2O2/FeSO4 for hydroxyl radicals, xanthine/xanthine oxidase for suproxide), we observed that Scutellaria baicalensis and grape seed proanthocyanidins acted synergistically to scavenge ROS. Our data suggest that a combination of these two herbs can potentially enhance their antioxidant efficacy, allowing lower dosages of each drug to be used. This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCUTELLARIA
KW - LAMIACEAE
KW - LAMIALES
KW - ANTHOCYANIDINS
KW - FLAVONOIDS
KW - Antioxidant
KW - Grape Seed Proanthocyanidins
KW - Herbal Medicine
KW - Hydroxyl Radicals
KW - Scutellaria baicalensis
KW - Suproxide
KW - Synergistic Effect
N1 - Accession Number: 13018168; Zuo-Hui Shao 1,2 Vanden Hoek, Terry L. 1,2 Chang-Qing Li 1,2 Schumacker, Paul T. 3 Becker, Lance B. 1,2 Kim Chai Chan 2 Yimin Qin 3 Jun-Jie Yin 4 Chun-Su Yuan 1,5,6; Email Address: cyuan@uchicago.edu; Affiliation: 1: Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago Chicago, IL, USA 2: Emergency Medicine and Emergency Resuscitation Center, The Pritzker School of Medicine, The University of Chicago Chicago, IL, USA 3: Department of Medicine, The Pritzker School of Medicine, The University of Chicago Chicago, IL, USA 4: Center for Food Safety and Applied Nutritions, United States Food and Drug Administration, College Park, MD, USA 5: Committee on Clinical Pharmacology and Pharmacogenomics, The Pritzker School of Medicine, The University of Chicago Chicago, IL, USA 6: Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago Chicago, IL, USA; Source Info: 2004, Vol. 32 Issue 1, p89; Subject Term: SCUTELLARIA; Subject Term: LAMIACEAE; Subject Term: LAMIALES; Subject Term: ANTHOCYANIDINS; Subject Term: FLAVONOIDS; Author-Supplied Keyword: Antioxidant; Author-Supplied Keyword: Grape Seed Proanthocyanidins; Author-Supplied Keyword: Herbal Medicine; Author-Supplied Keyword: Hydroxyl Radicals; Author-Supplied Keyword: Scutellaria baicalensis; Author-Supplied Keyword: Suproxide; Author-Supplied Keyword: Synergistic Effect; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mathews, Fiona
AU - Youngman, Linda
AU - Neil, Andrew
T1 - Maternal circulating nutrient concentrations in pregnancy: implications for birth and placental weights of term infants.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2004/01//
VL - 79
IS - 1
M3 - Article
SP - 103
EP - 110
SN - 00029165
AB - Background: Compromised fetal growth may program chronic diseases of adulthood, and it has been suggested that maternal nutrition is a major determinant of fetal growth. We previously found no clinically significant associations between maternal diet and the size of the infant and placenta at birth in a large cohort of white women living in the United Kingdom. Objective: The objective was to examine the relations between indexes of maternal nutritional status in pregnancy and the birth and placental weights of infants born at term. Design: We conducted a prospective cohort study of 798 white nulliparous women with singleton pregnancies. Blood samples were obtained at ≈16 and 28 wk of gestation. Results: The concentration of most nutrients was not associated with pregnancy outcome. High retinol and hemoglobin concentrations in late, but not in early, pregnancy were strongly and independently associated with lower birth weight and smaller placental size at birth. Each 0.1-μmol increase in retinol predicted a 20.8-g (95% CI: 9.2, 32.5 g) decrease in birth weight (P < 0.001), and each 0.1-g/L increase in hemoglobin predicted a 61.5-g (95% CI: 28.5, 94.4 g) decrease in birth weight (P < 0.001). Conclusions: We found negative associations between birth and placental weights and maternal retinol and hemoglobin concentrations. These relations may be causal or may reflect an underlying metabolic dysfunction, such as failure of plasma volume expansion. Our results provide no evidence that having high circulating nutrient concentrations, for example, through the use of supplements, would improve infant and placental growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - birth weight
KW - human
KW - nutrition
KW - placenta
KW - Pregnancy
KW - smoking
N1 - Accession Number: 94632228; Mathews, Fiona 1; Email Address: fiona.mathews@zoology.ox.ac.uk; Youngman, Linda 2; Neil, Andrew 3; Affiliations: 1: Department of Zoology, University of Oxford, Oxford, United Kingdom; 2: Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD; 3: Division of Public Health and Primary Health Care, University of Oxford, Institute of Health Sciences, Oxford, United Kingdom; Issue Info: Jan2004, Vol. 79 Issue 1, p103; Author-Supplied Keyword: birth weight; Author-Supplied Keyword: human; Author-Supplied Keyword: nutrition; Author-Supplied Keyword: placenta; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: smoking; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yong Qian
AU - Corum, Linda
AU - Qiao Meng, Linda
AU - Blenis, John
AU - Zheng, Jenny Z.
AU - Xianglin Shi
AU - Flynn, Daniel C.
AU - Bing-Hua Jiang
T1 - P13K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration.
JO - American Journal of Physiology: Cell Physiology
JF - American Journal of Physiology: Cell Physiology
Y1 - 2004/01//
VL - 55
IS - 1
M3 - Article
SP - C153
EP - C163
SN - 03636143
AB - This study was designed to identify the molecular mechanisms of phosphatidylinositol 3-kinase (PI3K)-induced actin filament remodeling and cell migration. Expression of active forms of P13K, v-P3k or Myr-P3k, was sufficient to induce actin filament remodeling to lead to an increase in cell migration, as well as the activation of Akt in chicken embryo fibroblast (CEF) cells. Either the inhibition of PI3K activity using a PI3K-specific inhibitor, LY294002, or the disruption of Akt activity restored the integrity of actin filaments in CEF cells and inhibited PI3K-induced cell migration. We also found that expression of an activated form of Akt (Myr-Akt) was sufficient to remodel actin filaments to lead to an increase in cell migration, which was unable to be inhibited by the presence of LY-294002. Furthermore, we found that p70S6K1 kinase was a downstream molecule that can mediate the effects of both PI3K and Akt on actin filaments and cell migration. Overexpression of an active form of p70S6K1 was sufficient to induce actin filament remodeling and cell migration in CEF cells, which requires Rac activity. These results demonstrate that activation of PI3K activity alone is sufficient to remodel actin filaments to increase cell migration through the activation of Akt and p70S6K1 in CEF cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Cell Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACTIN
KW - CELL migration
KW - PHOSPHOINOSITIDES
KW - CYTOLOGY
KW - ACTOMYOSIN
KW - CELL physiology
N1 - Accession Number: 12256878; Yong Qian 1,2; Email Address: yqian@cdc.gov Corum, Linda 2 Qiao Meng, Linda 2 Blenis, John 3 Zheng, Jenny Z. 2 Xianglin Shi 1 Flynn, Daniel C. 2 Bing-Hua Jiang 2; Email Address: bhjiang@hsc.wvu.edu; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 2: The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University 3: Department of Cell Biology, Harvard Medical School; Source Info: Jan2004, Vol. 55 Issue 1, pC153; Subject Term: ACTIN; Subject Term: CELL migration; Subject Term: PHOSPHOINOSITIDES; Subject Term: CYTOLOGY; Subject Term: ACTOMYOSIN; Subject Term: CELL physiology; Number of Pages: 11p; Illustrations: 31 Color Photographs, 14 Black and White Photographs, 1 Diagram, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Longkun Zhu, Kenneth B.
AU - Schwegler-Berry, Diane
AU - Castranova, Vince
AU - Pingnian He
T1 - Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability.
JO - American Journal of Physiology: Heart & Circulatory Physiology
JF - American Journal of Physiology: Heart & Circulatory Physiology
Y1 - 2004/01//
VL - 55
IS - 1
M3 - Article
SP - H195
EP - H201
SN - 03636135
AB - We demonstrated previously that inhibition of endothelial nitric oxide synthase (NOS), using pharmacological inhibitors, attenuated the ionomycin- and ATP-induced increases in microvessel permeability (Am J Physiol Heart Circ Physiol 272: H176-H185, 1997). Recently, the scaffolding domain of caveolin-1 (CAV) has been implicated as a negative regulator of endothelial NOS (eNOS). To examine the role of CAV-eNOS interaction in regulation of permeability in intact microvessels, the effect of internalized CAV on the platelet-activating factor (PAF)-induced permeability increase was investigated in rat mesenteric venular microvessels. Internalization of CAV was achieved by perfusion of individual vessels using a fusion peptide of CAV with Antennapedia homeodomain (AP-CAV) and visualized by fluorescence imaging and electron microscopy. Changes in microvessel permeability were evaluated by measuring hydraulic conductivity (L[sub p]) in individually perfused microvessels. We found that the PAF (10 nM)-induced L[sub p] increase was significantly attenuated from 6.0 ± 0.9 (n = 7) to 2.0 ± 0.3 (n = 5) times control after microvessels were perfused with 10 µM AP-CAV for 2 h. The magnitude of this reduction is comparable with that of the inhibitory effect of N[sup ω]-monomethyl-L-arginine on the PAF-induced L[sub p] increase. In contrast, perfusion with 10 µM AP alone for 2 h modified neither basal L[sub p] nor the vessel response to PAF. These results indicate that CAV plays an important role in regulation of microvessel permeability. The inhibitory action of CAV on permeability increase might be attributed to its direct inactivation of eNOS. In addition, this study established a method for studying protein-protein interaction-induced functional changes in intact microvessels and demonstrated AP as an efficient vector for translocation of peptide across the cell membrane in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Heart & Circulatory Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGICAL interactions
KW - PERMEABILITY
KW - BLOOD-vessels
KW - CARDIOVASCULAR system
KW - ENDOTHELIUM
KW - NITRIC oxide
N1 - Accession Number: 12256908; Longkun Zhu, Kenneth B. 1 Schwegler-Berry, Diane 2 Castranova, Vince 2 Pingnian He 1; Email Address: phe@hsc.wvu.edu; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University 2: Pathology and Physiology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, West Virginia; Source Info: Jan2004, Vol. 55 Issue 1, pH195; Subject Term: TOXICOLOGICAL interactions; Subject Term: PERMEABILITY; Subject Term: BLOOD-vessels; Subject Term: CARDIOVASCULAR system; Subject Term: ENDOTHELIUM; Subject Term: NITRIC oxide; Number of Pages: 7p; Illustrations: 2 Black and White Photographs, 1 Diagram, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roubideaux, Yvette
AU - Buchwald, Dedra
AU - Beals, Janette
AU - Manson, Spero
AU - Middlebrook, Denise
AU - Muneta, Ben
AU - Rith-Najarian, Steve
AU - Shields, Ray
AU - Acton, Kelly
T1 - Measuring the Quality of Diabetes Care for Older American Indians and Alaska Natives.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/01//
VL - 94
IS - 1
M3 - Article
SP - 60
EP - 65
PB - American Public Health Association
SN - 00900036
AB - Objectives. This study evaluated the quality of diabetes care for older American Indians and Alaska Natives. Methods. We analyzed the Indian Health Service Diabetes Care and Outcomes Audit to determine whether completion of indicators of diabetes care differed as a function of age and whether additional patient and program factors were also associated with completion of the majority of the indicators. Results. Completion rates varied by age group, with significantly lower rates seen among the youngest and oldest. Patient diabetes education and duration of diabetes were most strongly associated with the completion of the majority of these indicators. Conclusions. Further studies are needed to determine effective interventions, including diabetes education, to improve the quality of diabetes care in the youngest and oldest age groups. (Am J Public Health. 2004;94:60-65) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - MEDICAL care -- Evaluation
KW - OLDER Alaska Natives
KW - INDIGENOUS peoples of the Americas
KW - MEDICAL care
KW - HEALTH status indicators
KW - PATIENT education
N1 - Accession Number: 11952707; Roubideaux, Yvette 1; Email Address: yvetter@u.arizona.edu Buchwald, Dedra 2 Beals, Janette 3 Manson, Spero 3 Middlebrook, Denise 3 Muneta, Ben 4 Rith-Najarian, Steve 5 Shields, Ray 6 Acton, Kelly 7; Affiliation: 1: Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson 2: Department of Medicine, University of Washington, Seattle 3: Department of Psychiatry, University of Colorado Health Sciences Center, Denver 4: Indian Health Service Epidemiology Program, Albuquerque, NM 5: Indian Health Service, Bemidji Area, Cass Lake, Minn. 6: Indian Health Service, Portland Area, Bellingham, Wash. 7: Director, Indian Health Service National Diabetes Program, Albuquerque, NM; Source Info: Jan2004, Vol. 94 Issue 1, p60; Subject Term: DIABETES; Subject Term: MEDICAL care -- Evaluation; Subject Term: OLDER Alaska Natives; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: MEDICAL care; Subject Term: HEALTH status indicators; Subject Term: PATIENT education; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5349
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Michael J.
AU - Farrell, Dorothy E.
AU - Heller, David N.
AU - Yancy, Haile F.
T1 - Development of a polymerase chain reaction-based method to identify species-specific components in dog food.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 2004/01//
VL - 65
IS - 1
M3 - Article
SP - 99
EP - 103
SN - 00029645
AB - Objectives--To determine whether there is a relationship between species-specific mitochondrial DNA (mtDNA), especially canine and feline mtDNA, and detectable amounts of pentobarbital in previously analyzed dog food samples. Sample Population--31 dog food samples previously analyzed for pentobarbital (limit of detection, 1 µg/kg). Procedure--Polymerase chain reaction (PCR) analysis was performed on dog food samples by use of PCR primers specific for either canine, feline, equine, bovine, porcine, ovine, or poultry mtDNA. Results--PCR amplicons specific for feline or canine mtDNA at a 0.007% (70 µg/g [wt/wt basis]) or 0.0007% (7 µg/g) level, respectively, were not found in the 31 dog food samples. Most of the 31 dog food samples had a PCR amplicon on PCR analysis when a PCR primer set capable of simultaneously detecting mtDNA of cows, pigs, sheep, goats, deer, elk, and horses was used. Results of PCR analysis by use of primers specific for bovine, swine, sheep and goat, or horse mtDNA revealed amplicons specific for bovine or swine mtDNA only in 27 of the 31 samples. Analysis of the remaining 4 samples failed to yield amplicons for any mammalian mtDNA. Pentobarbital was detected in 2 of these 4 samples. Results of PCR analysis correlated with the stated ingredient list for most, but not all samples. Conclusions and Clinical Relevance--Because canine and feline mtDNA were not found in a set of retail dog food samples, these results indicate that the source of pentobarbital in dog food is something other than proteins from rendered pet remains. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Veterinary Research is the property of American Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIAL DNA
KW - PENTOBARBITAL
KW - DOGS -- Food
KW - POLYMERASE chain reaction
KW - LIVESTOCK
N1 - Accession Number: 12465355; Myers, Michael J. 1 Farrell, Dorothy E. 1 Heller, David N. 1 Yancy, Haile F. 1; Affiliation: 1: Division of Animal Research, Office of Research, Center for Veterinary Medicine, Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708; Source Info: Jan2004, Vol. 65 Issue 1, p99; Subject Term: MITOCHONDRIAL DNA; Subject Term: PENTOBARBITAL; Subject Term: DOGS -- Food; Subject Term: POLYMERASE chain reaction; Subject Term: LIVESTOCK; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 311111 Dog and Cat Food Manufacturing; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 5p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Phillips Jr., Robert L.
AU - Fryer, George E.
AU - Chen, Frederick M.
AU - Morgan, Sarah E.
AU - Green, Larry A.
AU - Valente, Ernest
AU - Miyoshi, Thomas J.
T1 - The Balanced Budget Act of 1997 and the Financial Health of Teaching Hospitals.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2004/01//Jan/Feb2004
VL - 2
IS - 1
M3 - Article
SP - 71
EP - 78
PB - Annals of Family Medicine
SN - 15441709
AB - Examines data related to the specific effects of the Balanced Budget Act of 1997 relative to the overall financial health of teaching hospitals in the United States. Definition of cost report variables and calculations; Prospective payment system; Graduate medical education.
KW - TEACHING hospitals -- Finance
KW - BUDGET -- Law & legislation
KW - PROSPECTIVE payment systems
KW - MEDICAL education
KW - MEDICAL care costs
KW - UNITED States
N1 - Accession Number: 12195711; Phillips Jr., Robert L. 1 Fryer, George E. 1 Chen, Frederick M. 2 Morgan, Sarah E. 3 Green, Larry A. 1 Valente, Ernest 4 Miyoshi, Thomas J. 5; Affiliation: 1: The Robert Graham Center in Washington, D.C. 2: Agency for Healthcare Research and Quality in Rockville, Maryland 3: Maine Medical Center Family Practice Residency Program 4: Pacific Business Group on Health in San Francisco, California 5: Dept. of Family Medicine, University of Colorado; Source Info: Jan/Feb2004, Vol. 2 Issue 1, p71; Subject Term: TEACHING hospitals -- Finance; Subject Term: BUDGET -- Law & legislation; Subject Term: PROSPECTIVE payment systems; Subject Term: MEDICAL education; Subject Term: MEDICAL care costs; Subject Term: UNITED States; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sheng Chen
AU - Shaohua Zhao
AU - White, David G.
AU - Schroeder, Carl M.
AU - Ran Lu
AU - Hanchun Yang, Carl M.
AU - McDermott, Patrick F.
AU - Ayers, Sherry
AU - Jianghong Meng
T1 - Characterization of Multiple-Antimicrobial-Resistant Salmonella Serovars Isolated from Retail Meats.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/01//
VL - 70
IS - 1
M3 - Article
SP - 1
EP - 7
SN - 00992240
AB - A total of 133 Salmonella isolates recovered from retail meats purchased in the United States and the People's Republic of China were assayed for antimicrobial susceptibility, the presence of integrons and antimicrobial resistance genes, and horizontal transfer of characterized antimicrobial resistance determinants via conjugation. Seventy-three (82%) of these Salmonella isolates were resistant to at least one antimicrobial agent. Resistance to the following antibiotics was common among the United States isolates: tetracycline (68% of the isolates were resistant), streptomycin (61%), sulfamethoxazole (42%), and ampicillin (29%). Eight Salmonella isolates (6%) were resistant to ceftriaxone. Fourteen isolates (11%) from the People's Republic of China were resistant to nalidixic acid and displayed decreased susceptibility to ciprofloxacin. A total of 19 different antimicrobial resistance genes were identified in 30 multidrug-resistant Salmonella isolates. The bla[sub CMY-2] gene, encoding a class A AmpC β-lactamase, was detected in all 10 Salmonella isolates resistant to extended-spectrum β-lactams. Resistance to ampicillin was most often associated with a TEM-1 family β-lactamase gene. Six aminoglycoside resistance genes, aadA1, aadA2, aacC2, Kn, aph(3)-Ila, and aac(3)-IVa, were commonly present in the Salmonella isolates. Sixteen (54%) of 30 Salmonella isolates tested had integrons ranging in size from 0.75 to 2.7 kb. Conjugation studies demonstrated that there was plasmid-mediated transfer of genes encoding CMY-2 and TEM-1-like β-lactamases. These data indicate that Salmonella isolates recovered from retail raw meats are commonly resistant to multiple antimicrobials, including those used for treating salmonellosis, such as ceftriaxone. Genes conferring antimicrobial resistance in Salmonella are often carried on integrons and plasmids and could be transmitted through conjugation. These mobile DNA elements have likely played an important role in transmission and dissemination of antimicrobial resistance determinants among Salmonella strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - MEAT
KW - GENES
KW - ANTIBIOTICS
KW - UNITED States
KW - CHINA
N1 - Accession Number: 12274738; Sheng Chen 1 Shaohua Zhao 2 White, David G. 2 Schroeder, Carl M. 1,3 Ran Lu 4 Hanchun Yang, Carl M. 5 McDermott, Patrick F. 2 Ayers, Sherry 2 Jianghong Meng 1; Email Address: jm332@umail.umd.edu; Affiliation: 1: Department of Nutrition and Food Sciences, University of Maryland 2: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration 3: Food Safety and Inspection Service, Unites States Department of Agriculture 4: Institute for Food Safety & Inspection, Ministry of Health 5: China Agricultural University; Source Info: Jan2004, Vol. 70 Issue 1, p1; Subject Term: SALMONELLA; Subject Term: MEAT; Subject Term: GENES; Subject Term: ANTIBIOTICS; Subject Term: UNITED States; Subject Term: CHINA; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1128/AEM.70.1.1-7.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moody, Joanna D.
AU - Freeman, James P.
AU - Fu, Peter P.
AU - Cerniglia, Carl E.
T1 - Degradation of Benzo[a]pyrene by Mycobacterium vanbaalenii PYR-1.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/01//
VL - 70
IS - 1
M3 - Article
SP - 340
EP - 345
SN - 00992240
AB - Metabolism of the environmental pollutant benzo[a]pyrene in the bacterium Mycobacterium vanbaalenii PYR-1 was examined. This organism initially oxidized benzo[a]pyrene with dioxygenases and monooxygenases at C-4,5, C-9,10, and C-11,12. The metabolites were separated by reversed-phase high-performance liquid chromatography (HPLC) and characterized by UV-visible, mass, nuclear magnetic resonance, and circular dichroism spectral analyses. The major intermediates of benzo[a]pyrene metabolism that had accumulated in the culture media after 96 h of incubation were cis-4,5-dihydro-4,5-dihydroxybenzo[a]pyrene (benzo[a]pyrene cis-4,5-dihydrodiol), cis-11,12-dihydro-11,12-dihydroxybenzo[a]pyrene (benzo[a]pyrene cis-11,12-dihydrodiol), trans-11,12-dihydro-11,12-dihydroxybenzo[a]pyrene (benzo[a]pyrene trans-11,12-dihydrodiol), 10-oxabenzo[def]chrysen-9-one, and hydroxymethoxy and dimethoxy derivatives of benzo[a]pyrene. The ortho-ring fission products 4-formylchrysene-5-carboxylic acid and 4,5-chrysene-dicarboxylic acid and a monocarboxylated chrysene product were formed when replacement culture experiments were conducted with benzo[a]pyrene cis-4,5-dihydrodiol. Chiral stationary-phase HPLC analysis of the dihydrodiols indicated that benzo[a]pyrene cis-4,5-dihydrodiol had 30% 4S,5R and 70% 4R,5S absolute stereochemistry. Benzo[a]pyrene cis-11,12-dihydrodiol adopted an 11S,12R conformation with 100% optical purity. The enantiomeric composition of benzo[a]pyrene trans-11,12-dihydrodiol was an equal mixture of 11S,12S and 11R,12R molecules. The results of this study, in conjunction with those of previously reported studies, extend the pathways proposed for the bacterial metabolism of benzo[a]pyrene. Our study also provides evidence of the stereo- and regio-selectivity of the oxygenases that catalyze the metabolism of benzo[a] pyrene in M. vanbaalenii PYR-1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM
KW - PYRENE (Chemical)
KW - BIODEGRADATION
KW - METABOLISM
KW - CIRCULAR dichroism
KW - CULTURE media (Biology)
N1 - Accession Number: 12274780; Moody, Joanna D. 1 Freeman, James P. 2 Fu, Peter P. Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration; Source Info: Jan2004, Vol. 70 Issue 1, p340; Subject Term: MYCOBACTERIUM; Subject Term: PYRENE (Chemical); Subject Term: BIODEGRADATION; Subject Term: METABOLISM; Subject Term: CIRCULAR dichroism; Subject Term: CULTURE media (Biology); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Graphs; Document Type: Article
L3 - 10.1128/AEM.70.1.340-345.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Panicker, Gitika
AU - Myers, Michael L.
AU - Bej, Asim K.
T1 - Rapid Detection of Vibrio vulnificus in Shellfish and Gulf of Mexico Water by Real-Time PCR.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/01//
VL - 70
IS - 1
M3 - Article
SP - 498
EP - 507
SN - 00992240
AB - A pink-pigmented symbiotic bacterium was isolated from hybrid poplar tissues (Populus deltoides × nigra DN34). The bacterium was identified by 16S and 16S-23S intergenic spacer ribosomal DNA analysis as a Methylobacterium sp. (strain BJ001). The isolated bacterium was able to use methanol as the sole source of carbon and energy, which is a specific attribute of the genus Methylobacterium. The bacterium in pure culture was shown to degrade the toxic explosives 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazene (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5-tetrazocine (HMX). [U-ring-[sup 14]C]TNT (25 mg liter[sup -1]) was fully transformed in less than 10 days. Metabolites included the reduction derivatives amino-dinitrotoluenes and diamino-nitrotoluenes. No significant release of [sup 14]CO[sub 2] was recorded from [[sup 14]C]TNT. In addition, the isolated methylotroph was shown to transform [U-[sup 14]C]RDX (20 mg liter[sup -1]) and [U-[sup 14]C]HMX (2.5 mg liter[sup -1]) in less than 40 days. After 55 days of incubation, 58.0% of initial [[sup 14]C]RDX and 61.4% of initial [[sup 14]C]HMX were mineralized into [sup 14]CO[sub 2]. The radioactivity remaining in solution accounted for 12.8 and 12.7% of initial [[sup 14]C]RDX and [[sup 14]C]HMX, respectively. Metabolites detected from RDX transformation included a mononitroso RDX derivative and a polar compound tentatively identified as methylenedinitramine. Since members of the genus Methylobacterium are distributed in a wide diversity of natural environments and are very often associated with plants, Methylobacterium sp. strain BJ001 may be involved in natural attenuation or in situ biodegradation (including phytoremediation) of explosive-contaminated sites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLOBACTERIUM
KW - BIODEGRADATION
KW - TNT (Chemical)
KW - TISSUES
KW - DNA
KW - RIBOSOMES
N1 - Accession Number: 12274800; Panicker, Gitika 1 Myers, Michael L. 1,2 Bej, Asim K. 1; Email Address: abej@uab.edu; Affiliation: 1: Department of Biology, University of Alabama at Birmingham 2: U.S. Food and Drug Administration; Source Info: Jan2004, Vol. 70 Issue 1, p498; Subject Term: METHYLOBACTERIUM; Subject Term: BIODEGRADATION; Subject Term: TNT (Chemical); Subject Term: TISSUES; Subject Term: DNA; Subject Term: RIBOSOMES; NAICS/Industry Codes: 325920 Explosives Manufacturing; Number of Pages: 10p; Illustrations: 7 Charts, 7 Graphs; Document Type: Article
L3 - 10.1128/AEM.70.1.498-507.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chapman, Larry J.
AU - Newenhouse, Astrid C.
AU - Meyer, Robert H.
AU - Taveira, Alvaro D.
AU - Karsh, Ben-Tzion
AU - Ehlers, Janet J.
AU - Palermo, Teri
T1 - Evaluation of an intervention to reduce musculoskeletal hazards among fresh market vegetable growers
JO - Applied Ergonomics
JF - Applied Ergonomics
Y1 - 2004/01//
VL - 35
IS - 1
M3 - Article
SP - 57
SN - 00036870
AB - Objectives: We conducted an intervention to convince small, fresh market vegetable operations to adopt mesh bags and standard containers, two production practices that aid in crop handling and that are known to improve labor efficiency and reduce exposures to musculoskeletal injury hazards.Methods: The intervention disseminated information about the practices to growers through trade publications, public events, university Extension, and growers already using the practices. A mail questionnaire was administered to vegetable growers (n=243 and 207) before and after the intervention. Strawberry growers were used as a comparison group and also received questionnaires (n=50 and 35).Results: After the intervention, more vegetable growers reported seeing information about mesh bags in trade publications (37% vs. 59%) and information about standard containers at public events (33% vs. 49%). Levels of self-reported adoption increased for containers (38% vs. 54%) and approached significance for bags (8% vs. 17%). Aware, non-adopting grower perceptions of bag profitability improved (2.6 vs. 3.8). Strawberry grower control results were unchanged.Conclusions: Better information flow to growers may be able to increase the speed with which agricultural practices with better ergonomics are adopted, especially when the practices are more profitable. [Copyright &y& Elsevier]
AB - Copyright of Applied Ergonomics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURE
KW - INDUSTRIAL hygiene
KW - MUSCULOSKELETAL system
KW - SAFETY
KW - Agriculture
KW - Intervention evaluation
KW - Occupational health
KW - Safety
N1 - Accession Number: 12308157; Chapman, Larry J. 1; Email Address: ljchapma@facstaff.wisc.edu Newenhouse, Astrid C. 1 Meyer, Robert H. 1 Taveira, Alvaro D. 2 Karsh, Ben-Tzion 3 Ehlers, Janet J. 4 Palermo, Teri 5; Affiliation: 1: Biological Systems Engineering Department, University of Wisconsin, 460 Henry Mall, Madison, WI 53706, USA 2: Occupational and Environmental Safety and Health Department, University of Wisconsin, 800 West Main Street, Whitewater, WI 53190, USA 3: Industrial Engineering Department, University of Wisconsin, 1513 University Avenue, Madison, WI 53706, USA 4: US National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 5: US National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, WV 26505, USA; Source Info: Jan2004, Vol. 35 Issue 1, p57; Subject Term: AGRICULTURE; Subject Term: INDUSTRIAL hygiene; Subject Term: MUSCULOSKELETAL system; Subject Term: SAFETY; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: Intervention evaluation; Author-Supplied Keyword: Occupational health; Author-Supplied Keyword: Safety; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.apergo.2003.05.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, A. A.
AU - Kisin, E. R.
AU - Murray, A.
AU - Kommineni, C.
AU - Vallyathan, V.
AU - Castranova, V.
T1 - Pro/antioxidant Status in Murine Skin Following Topical Exposure to Cumene Hydroperoxide Throughout the Ontogeny of Skin Cancer.
JO - Biochemistry (00062979)
JF - Biochemistry (00062979)
Y1 - 2004/01//
VL - 69
IS - 1
M3 - Article
SP - 23
EP - 31
PB - Springer Science & Business Media B.V.
SN - 00062979
AB - Organic peroxides used in the chemical and pharmaceutical industries have a reputation for being potent skin tumor promoters and inducers of epidermal hyperplasia. Their ability to trigger free radical generation is critical for their carcinogenic properties. Short-term in vivo exposure of mouse skin to cumene hydroperoxide (Cum-OOH) causes severe oxidative stress and formation of spin-trapped radical adducts. The present study was designed to determine the effectiveness of Cum-OOH compared to 12-O-tetradecanoylphorbol-13-acetate (TPA) in the induction of tumor promotion in the mouse skin, to identify the involvement of cyclooxygenase-2 (COX-2) in oxidative metabolism of Cum-OOH in keratinocytes, and to evaluate morphological changes and outcomes of oxidative stress in skin of SENCAR mice throughout a two-stage carcinogenesis protocol. Dimethyl-benz[a]anthracene (DMBA)-initiated mice were treated with Cum-OOH (32.8 μmol) or TPA (8.5 nmol) twice weekly for 20 weeks to promote papilloma formation. Skin carcinoma formed only in DMBA/Cum-OOH-exposed mice. Higher levels of oxidative stress and inflammation (as indicated by the accumulation of peroxidative products, antioxidant depletion, and edema formation) were evident in the DMBA/Cum-OOH group compared to DMBA/TPA treated mice. Exposure of keratinocytes (HaCaT) to Cum-OOH for 18 h resulted in expression of COX-2 and increased levels of PGE2. Inhibitors of COX-2 efficiently suppressed oxidative stress and enzyme expression in the cells treated with Cum-OOH. These results suggest that COX-2-dependent oxidative metabolism is at least partially involved in Cum-OOH-induced inflammatory responses and thus tumor promotion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry (00062979) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Tumors
KW - PEROXIDES
KW - EPIDERMIS
KW - HYPERPLASIA
KW - OXIDATIVE stress
KW - TUMORS -- Growth
KW - 12-O-tetradecanoylphorbol-13-acetate
KW - cumene hydroperoxide
KW - oxidative stress
KW - skin
KW - tumor promotion
N1 - Accession Number: 16906260; Shvedova, A. A. 1,2; Email Address: ats1@cdc.gov Kisin, E. R. 1 Murray, A. 2 Kommineni, C. 1 Vallyathan, V. 1 Castranova, V. 1,2; Affiliation: 1: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, m/s 2015, Morgantown, West Virginia, USA. 2: Physiology and Pharmacology Department, West Virginia University, Morgantown, WV, USA.; Source Info: Jan2004, Vol. 69 Issue 1, p23; Subject Term: SKIN -- Tumors; Subject Term: PEROXIDES; Subject Term: EPIDERMIS; Subject Term: HYPERPLASIA; Subject Term: OXIDATIVE stress; Subject Term: TUMORS -- Growth; Author-Supplied Keyword: 12-O-tetradecanoylphorbol-13-acetate; Author-Supplied Keyword: cumene hydroperoxide; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: skin; Author-Supplied Keyword: tumor promotion; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Castranova, V.
T1 - Role of Nitric Oxide in the Progression of Pneumoconiosis.
JO - Biochemistry (00062979)
JF - Biochemistry (00062979)
Y1 - 2004/01//
VL - 69
IS - 1
M3 - Article
SP - 32
EP - 37
PB - Springer Science & Business Media B.V.
SN - 00062979
AB - Conflicting evidence has been reported as to whether nitric oxide (NO) possesses anti-inflammatory or inflammatory properties. Data are presented indicating that in vitro or in vivo exposure to selected occupational dusts, i.e., crystalline silica, organic dust contaminated with endotoxin, or asbestos, results in upregulation of inducible nitric oxide synthase (iNOS) and the production of NO by alveolar macrophages and pulmonary epithelial cells. Nitric oxide production is associated temporally and anatomically with pulmonary damage, inflammation, and disease progression in response to occupational dusts. Blockage of inducible nitric oxide synthase by administration of NOS inhibitors or in iNOS knockout mice decreases the magnitude of injury and inflammation following in vivo exposure to silica, endotoxin, or asbestos. Therefore, NO may play an important role in the initiation and progression of pneumoconiosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry (00062979) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Dust diseases
KW - NITRIC oxide
KW - SILICA
KW - ENDOTOXINS
KW - ASBESTOS
KW - NITRIC-oxide synthases
KW - asbestos
KW - asbestosis
KW - byssinosis
KW - cotton dust
KW - crystalline silica
KW - endotoxin
KW - iNOS
KW - LPS
KW - nitric oxide
KW - pneumoconiosis
KW - silicosis
N1 - Accession Number: 16906259; Castranova, V. 1; Email Address: vic1@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA.; Source Info: Jan2004, Vol. 69 Issue 1, p32; Subject Term: LUNGS -- Dust diseases; Subject Term: NITRIC oxide; Subject Term: SILICA; Subject Term: ENDOTOXINS; Subject Term: ASBESTOS; Subject Term: NITRIC-oxide synthases; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: asbestosis; Author-Supplied Keyword: byssinosis; Author-Supplied Keyword: cotton dust; Author-Supplied Keyword: crystalline silica; Author-Supplied Keyword: endotoxin; Author-Supplied Keyword: iNOS; Author-Supplied Keyword: LPS; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: pneumoconiosis; Author-Supplied Keyword: silicosis; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang, Isaac A.
AU - Nguyen, Uyen D.
T1 - Thermal modeling of lesion growth with radiofrequency ablation devices.
JO - BioMedical Engineering OnLine
JF - BioMedical Engineering OnLine
Y1 - 2004/01//
VL - 3
M3 - Article
SP - 27
EP - 19
PB - BioMed Central
SN - 1475925X
AB - Background: Temperature is a frequently used parameter to describe the predicted size of lesions computed by computational models. In many cases, however, temperature correlates poorly with lesion size. Although many studies have been conducted to characterize the relationship between time-temperature exposure of tissue heating to cell damage, to date these relationships have not been employed in a finite element model. Methods: We present an axisymmetric two-dimensional finite element model that calculates cell damage in tissues and compare lesion sizes using common tissue damage and iso-temperature contour definitions. The model accounts for both temperature-dependent changes in the electrical conductivity of tissue as well as tissue damage-dependent changes in local tissue perfusion. The data is validated using excised porcine liver tissues. Results: The data demonstrate the size of thermal lesions is grossly overestimated when calculated using traditional temperature isocontours of 42°C and 47°C. The computational model results predicted lesion dimensions that were within 5% of the experimental measurements. Conclusion: When modeling radiofrequency ablation problems, temperature isotherms may not be representative of actual tissue damage patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRECANCEROUS conditions
KW - MATHEMATICAL models
KW - RADIO frequency
KW - TEMPERATURE
KW - FINITE element method
N1 - Accession Number: 28781996; Chang, Isaac A. 1; Email Address: IAC@CDRH.FDA.GOV Nguyen, Uyen D. 2; Email Address: nguyenu@cua.edu; Affiliation: 1: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, USA 2: Department of Biomedical Engineering, Catholic University of America, Washington DC, USA; Source Info: 2004, Vol. 3, p27; Subject Term: PRECANCEROUS conditions; Subject Term: MATHEMATICAL models; Subject Term: RADIO frequency; Subject Term: TEMPERATURE; Subject Term: FINITE element method; Number of Pages: 19p; Illustrations: 1 Color Photograph, 6 Diagrams, 8 Charts, 3 Graphs; Document Type: Article
L3 - 10.1186/1475-925X-3-27
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beard, Brian B.
AU - Kainz, Wolfgang
T1 - Review and standardization of cell phone exposure calculations using the SAM phantom and anatomically correct head models.
JO - BioMedical Engineering OnLine
JF - BioMedical Engineering OnLine
Y1 - 2004/01//
VL - 3
M3 - Article
SP - 34
EP - 10
PB - BioMed Central
SN - 1475925X
AB - We reviewed articles using computational RF dosimetry to compare the Specific Anthropomorphic Mannequin (SAM) to anatomically correct models of the human head. Published conclusions based on such comparisons have varied widely. We looked for reasons that might cause apparently similar comparisons to produce dissimilar results. We also looked at the information needed to adequately compare the results of computational RF dosimetry studies. We concluded studies were not comparable because of differences in definitions, models, and methodology. Therefore we propose a protocol, developed by an IEEE standards group, as an initial step in alleviating this problem. The protocol calls for a benchmark validation study comparing the SAM phantom to two anatomically correct models of the human head. It also establishes common definitions and reporting requirements that will increase the comparability of all computational RF dosimetry studies of the human head. [ABSTRACT FROM AUTHOR]
AB - Copyright of BioMedical Engineering OnLine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL phones
KW - RADIO frequency
KW - RADIATION dosimetry
KW - HEAD
KW - MODELS & modelmaking
N1 - Accession Number: 28782003; Beard, Brian B. 1; Email Address: brian.beard@fda.hhs.gov Kainz, Wolfgang 1; Email Address: wolfgang.kainz@fda.hhs.gov; Affiliation: 1: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2004, Vol. 3, p34; Subject Term: CELL phones; Subject Term: RADIO frequency; Subject Term: RADIATION dosimetry; Subject Term: HEAD; Subject Term: MODELS & modelmaking; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 443142 Electronics Stores; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 334220 Radio and Television Broadcasting and Wireless Communications Equipment Manufacturing; NAICS/Industry Codes: 517210 Wireless Telecommunications Carriers (except Satellite); Number of Pages: 10p; Illustrations: 7 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1186/1475-925X-3-34
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2004-18300-015
AN - 2004-18300-015
AU - DeMartino, Robert
AU - Flynn, Brian W.
ED - Ursano, Robert J.
ED - Norwood, Ann E.
ED - Fullerton, Carol S.
ED - Ursano, Robert J., (Ed)
ED - Norwood, Ann E., (Ed)
ED - Fullerton, Carol S., (Ed)
T1 - Bioterrorism: a strategy for psychosocial preparedness, response, and recovery.
T2 - Bioterrorism: Psychological and public health interventions.
Y1 - 2004///
SP - 274
EP - 289
CY - New York, NY, US
PB - Cambridge University Press
SN - 0-521-81472-3
N1 - Accession Number: 2004-18300-015. Partial author list: First Author & Affiliation: DeMartino, Robert; Program in Trauma and Terrorism, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Service, US. Release Date: 20051121. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-521-81472-3, Hardcover. Language: English. Major Descriptor: Coping Behavior; Experiences (Events); Psychosocial Factors; Responses; Terrorism. Minor Descriptor: Behavior; Bioterrorism; Prevention; Social Behavior. Classification: Social Processes & Social Issues (2900). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 16.
AB - A defining feature of bioterrorism is that its consequences will be judged almost exclusively in terms of its human and social costs--death, disability, and social disruption, and the economic toll thereby wrought--in both the short- and long-term. In fact, the material 'structure' of a community following bioterrorism may appear eerily unchanged by the event that has taken its toll in human lives. Notwithstanding the mass casualties potentially associated with bioterrorism, planning for its behavioral and psychosocial casualties is fraught with difficulties because of the range of sequelae for which planners must prepare. In this chapter we will be referring to several dimensions of the human experience: the psychological (internal emotional states), the behavioral (observable acts), and the social (activities of interpersonal and societal functioning) to describe the processes and consequences that are relevant to planning, response, and recovery. When we use the terms psychosocial or 'mental health' in this context, we mean to refer to ideas that incorporate or cross all three of these dimensions. In this chapter we often address the psychological reactions to bioterrorism and the collection of fear-induced behaviors in individuals and groups that may result. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial preparedness
KW - bioterrorism
KW - human experience
KW - responses
KW - recovery
KW - psychological experience
KW - behavioral experience
KW - social experience
KW - 2004
KW - Coping Behavior
KW - Experiences (Events)
KW - Psychosocial Factors
KW - Responses
KW - Terrorism
KW - Behavior
KW - Bioterrorism
KW - Prevention
KW - Social Behavior
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18300-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Brandenberger, Ralph
AU - Khrebtukova, Irina
AU - Thies, R. Scott
AU - Miura, Takumi
AU - Cai Jingli
AU - Raj Puri
AU - Vasicek, Tom
AU - Lebkowski, Jane
AU - Rao, Mahendra
T1 - MPSS profiling of human embryonic stem cells.
JO - BMC Developmental Biology
JF - BMC Developmental Biology
Y1 - 2004/01//
VL - 4
M3 - Article
SP - 10
EP - 16
PB - BioMed Central
SN - 1471213X
AB - Background: Pooled human embryonic stem cells (hESC) cell lines were profiled to obtain a comprehensive list of genes common to undifferentiated human embryonic stem cells. Results: Pooled hESC lines were profiled to obtain a comprehensive list of genes common to human ES cells. Massively parallel signature sequencing (MPSS) of approximately three million signature tags (signatures) identified close to eleven thousand unique transcripts, of which approximately 25% were uncharacterised or novel genes. Expression of previously identified ES cell markers was confirmed and multiple genes not known to be expressed by ES cells were identified by comparing with public SAGE databases, EST libraries and parallel analysis by microarray and RTPCR. Chromosomal mapping of expressed genes failed to identify major hotspots and confirmed expression of genes that map to the X and Y chromosome. Comparison with published data sets confirmed the validity of the analysis and the depth and power of MPSS. Conclusions: Overall, our analysis provides a molecular signature of genes expressed by undifferentiated ES cells that can be used to monitor the state of ES cells isolated by different laboratories using independent methods and maintained under differing culture conditions [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Developmental Biology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMBRYONIC stem cells
KW - GENES
KW - CELL lines
KW - GENE mapping
KW - X chromosome
KW - Y chromosome
N1 - Accession Number: 28808444; Brandenberger, Ralph 1; Email Address: RBrandenberger@Geron.com Khrebtukova, Irina 2; Email Address: irina@lynxgen.com Thies, R. Scott 3; Email Address: SThies@Geron.com Miura, Takumi 1; Email Address: caiji@grc.nia.nih.gov Cai Jingli; Email Address: miurata@grc.nia.nih.gov Raj Puri 4; Email Address: puri@cber.FDA.gov Vasicek, Tom 2; Email Address: tvasicek@lynxgen.com Lebkowski, Jane 3; Email Address: JLebkowski@Geron.com Rao, Mahendra 1; Email Address: raomah@grc.nia.nih.gov; Affiliation: 1: National Institute on Aging; GRC; Laboratory of Neuroscience, 5600 Nathan Shock Drive; Room 4E02; Baltimore, MD 21224, USA 2: Lynx Therapeutics, Inc. 25861 Industrial Blvd., Hayward, CA 94545, USA 3: Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA 4: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; Source Info: 2004, Vol. 4, p10; Subject Term: EMBRYONIC stem cells; Subject Term: GENES; Subject Term: CELL lines; Subject Term: GENE mapping; Subject Term: X chromosome; Subject Term: Y chromosome; Number of Pages: 16p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
L3 - 10.1186/1471-213X-4-10
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vodkin, Lila O.
AU - Khanna, Anupama
AU - Shealy, Robin
AU - Clough, Steven J.
AU - Gonzalez, Delkin Orlando
AU - Philip, Reena
AU - Zabala, Gracia
AU - Thibaud-Nissen, Françoise
AU - Sidarous, Mark
AU - Strömvik, Martina V.
AU - Shoop, Elizabeth
AU - Schmidt, Christina
AU - Retzel, Ernest
AU - Erpelding, John
AU - Shoemaker, Randy C.
AU - Rodriguez-Huete, Alicia M.
AU - Polacco, Joseph C.
AU - Coryell, Virginia
AU - Keim, Paul
AU - Gong, George
T1 - Microarrays for global expression constructed with a low redundancy set of 27,500 sequenced cDNAs representing an array of developmental stages and physiological conditions of the soybean plant.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2004/01//
VL - 5
M3 - Article
SP - 73
EP - 18
PB - BioMed Central
SN - 14712164
AB - Background: Microarrays are an important tool with which to examine coordinated gene expression. Soybean (Glycine max) is one of the most economically valuable crop species in the world food supply. In order to accelerate both gene discovery as well as hypothesis-driven research in soybean, global expression resources needed to be developed. The applications of microarray for determining patterns of expression in different tissues or during conditional treatments by dual labeling of the mRNAs are unlimited. In addition, discovery of the molecular basis of traits through examination of naturally occurring variation in hundreds of mutant lines could be enhanced by the construction and use of soybean cDNA microarrays. Results: We report the construction and analysis of a low redundancy 'unigene' set of 27,513 clones that represent a variety of soybean cDNA libraries made from a wide array of source tissue and organ systems, developmental stages, and stress or pathogen-challenged plants. The set was assembled from the 5′ sequence data of the cDNA clones using cluster analysis programs. The selected clones were then physically reracked and sequenced at the 3′ end. In order to increase gene discovery from immature cotyledon libraries that contain abundant mRNAs representing storage protein gene families, we utilized a high density filter normalization approach to preferentially select more weakly expressed cDNAs. All 27,513 cDNA inserts were amplified by polymerase chain reaction. The amplified products, along with some repetitively spotted control or 'choice' clones, were used to produce three 9,728-element microarrays that have been used to examine tissue specific gene expression and global expression in mutant isolines. Conclusions: Global expression studies will be greatly aided by the availability of the sequence-validated and low redundancy cDNA sets described in this report. These cDNAs and ESTs represent a wide array of developmental stages and physiological conditions of the soybean plant. We also demonstrate that the quality of the data from the soybean cDNA microarrays is sufficiently reliable to examine isogenic lines that differ with respect to a mutant phenotype and thereby to define a small list of candidate genes potentially encoding or modulated by the mutant phenotype. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - ANTISENSE DNA
KW - SOYBEAN
KW - GENE expression
KW - MESSENGER RNA
KW - POLYMERASE chain reaction
N1 - Accession Number: 28859363; Vodkin, Lila O. 1; Email Address: l-vodkin@uiuc.edu Khanna, Anupama 1,2; Email Address: anupama.khanna@epicentre.com Shealy, Robin 1; Email Address: l-vodkin@uiuc.edu Clough, Steven J. 1,3; Email Address: sjclough@uiuc.edu Gonzalez, Delkin Orlando 1; Email Address: dogonzal@uiuc.edu Philip, Reena 1,4; Email Address: philipreena@yahoo.com Zabala, Gracia 1; Email Address: g-zabala@uiuc.edu Thibaud-Nissen, Françoise 1,5; Email Address: fthibaud@tigr.org Sidarous, Mark 1; Email Address: sidarous@uiuc.edu Strömvik, Martina V. 6,7; Email Address: martina.stromvik@mcgill.ca Shoop, Elizabeth 6,8; Email Address: schoop@macalester.edu Schmidt, Christina 6; Email Address: shoop@macalesler.edu Retzel, Ernest 6; Email Address: ernest@mail.ahc.umn.edu Erpelding, John 9; Email Address: rcsshoe@iastate.edu Shoemaker, Randy C. 9; Email Address: rcsshoe@iastate.edu Rodriguez-Huete, Alicia M. 10,11; Email Address: PolaccoJ@missouri.edu Polacco, Joseph C. 10; Email Address: PolaccoJ@missouri.edu Coryell, Virginia 12; Email Address: Paul.Keim@nau.edu Keim, Paul 12; Email Address: Paul.Keim@nau.edu Gong, George 13; Email Address: ligong@uiuc.edu; Affiliation: 1: Department of Crop Sciences, University of Illinois, Urbana, IL, 61801, USA 2: Epicentre, 726 Post Road, Madison, WI, 53713, USA 3: USDA/ARS, National Soybean Research Laboratory, University of Illinois, Urbana, IL, 61801, USA 4: Food and Drug Administration, Rockeville, MD, 20850, USA 5: The Institute for Genome Research, 9212 Medical Center Drive, Rockville, MD, 20850, USA 6: Center for Computational Genomics and Bioinformatics, University of Minnesota, Minneapolis, MN, 55455, USA 7: Department of Plant Science, McGill University, 2111 Lakeshore, St. Anne-de-Bellevue, QC, H9X3V9, Canada 8: Mathematics and Computer Science, Macalester College, St. Paul, MN, 55105, USA 9: USDA/ARS, Department of Agronomy, Iowa State University, Ames, IA, 50011, USA 10: Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA 11: Department of Microbiology, School of Medicine, University of Nevada-Reno, Reno, NV, USA 12: Department of Biology, Northern Arizona University, Flagstaff, AZ, 86011, USA 13: Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, IL, 61801, USA; Source Info: 2004, Vol. 5, p73; Subject Term: DNA microarrays; Subject Term: ANTISENSE DNA; Subject Term: SOYBEAN; Subject Term: GENE expression; Subject Term: MESSENGER RNA; Subject Term: POLYMERASE chain reaction; NAICS/Industry Codes: 111110 Soybean Farming; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 18p; Illustrations: 2 Diagrams, 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1186/1471-2164-5-73
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28859363&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atkins, David
AU - Eccles, Martin
AU - Flottorp, Signe
AU - Guyatt, Gordon H.
AU - Henry, David
AU - Hill, Suzanne
AU - Liberati, Alessandro
AU - O'Connell, Dianne
AU - Oxman, Andrew D.
AU - Phillips, Bob
AU - Schünemann, Holger
AU - Edejer, Tessa Tan-Torres
AU - Vist, Gunn E.
AU - Williams Jr., John W.
T1 - Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group.
JO - BMC Health Services Research
JF - BMC Health Services Research
Y1 - 2004/01//
VL - 4
M3 - Article
SP - 38
EP - 7
PB - BioMed Central
SN - 14726963
AB - Background: A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and communicate this information so that it can easily be understood and thereby help people make well-informed decisions. Our objective was to critically appraise six prominent systems for grading levels of evidence and the strength of recommendations as a basis for agreeing on characteristics of a common, sensible approach to grading levels of evidence and the strength of recommendations. Methods: Six prominent systems for grading levels of evidence and strength of recommendations were selected and someone familiar with each system prepared a description of each of these. Twelve assessors independently evaluated each system based on twelve criteria to assess the sensibility of the different approaches. Systems used by 51 organisations were compared with these six approaches. Results: There was poor agreement about the sensibility of the six systems. Only one of the systems was suitable for all four types of questions we considered (effectiveness, harm, diagnosis and prognosis). None of the systems was considered usable for all of the target groups we considered (professionals, patients and policy makers). The raters found low reproducibility of judgements made using all six systems. Systems used by 51 organisations that sponsor clinical practice guidelines included a number of minor variations of the six systems that we critically appraised. Conclusions: All of the currently used approaches to grading levels of evidence and the strength of recommendations have important shortcomings. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Health Services Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - EVIDENCE-based medicine
KW - DECISION making in clinical medicine
KW - MEDICINE -- Practice
KW - EVIDENCE-based management
N1 - Accession Number: 29324195; Atkins, David 1; Email Address: DAtkins@AHRQ.GOV Eccles, Martin 2; Email Address: Martin.Eccles@newcastle.ac.uk Flottorp, Signe 3; Email Address: signe.flottorp@nhsrc.no Guyatt, Gordon H. 4,5; Email Address: guyatt@mcmaster.ca Henry, David 6; Email Address: mddah@mail.newcastle.edu.au Hill, Suzanne 6; Email Address: hillsu@mail.newcastle.edu.au Liberati, Alessandro 7,8; Email Address: alesslib@tin.it O'Connell, Dianne 9; Email Address: dianneo@nswcc.org.au Oxman, Andrew D. 3; Email Address: oxman@online.no Phillips, Bob 10; Email Address: bob.phillips@doctors.org.uk Schünemann, Holger 4,5,11,12; Email Address: hjs@buffalo.edu Edejer, Tessa Tan-Torres 13; Email Address: tantorrest@who.ch Vist, Gunn E. 3; Email Address: gev@nhsrc.no Williams Jr., John W. 14; Email Address: jw.williams@duke.edu; Affiliation: 1: Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd. Rokville, MD 20852, USA 2: Centre for Health Services Research, University of Newcastle upon Tyne, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, UK 3: Informed Choice Research Department, Norwegian Health Services Research Centre, Pb. 7004 St. Olavs Plass, 0130 Oslo, Norway 4: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada 5: Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada 6: Department of Clinical Pharmacology, Faculty of Medicine and Health Sciences, University of Newcastle, Level 5, New Med 2 Building, Newcastle Mater Hospital, Waratah, NSW 2298, Australia 7: Department of Oncology and Hematology, Università di Modena e Reggio Emilia, Azienda Ospedaliera Policlinico, Via dal Pozzo 41, 41100 Modena, Italia 8: Centro per la Valutazione della Efficacia della Assistenza Sanitaria (CeVEAS), Modena, Italy 9: Cancer Epidemiology Research Unit, Cancer Research and Registers Division, The Cancer Council NSW, PO Box 572, Kings Cross NSW 1340, Australia 10: Centre for Evidence-based Medicine, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK 11: Department of Medicine, University at Buffalo, State University of New York, ECMC-CC142, 462 Grinder St, Buffalo, NY 14215, USA 12: Department of Social & Preventive Medicine, University at Buffalo, State University of New York, ECMC-CC142, 462 Grinder St, Buffalo, NY 14215, USA 13: Global Programme on Evidence for Health Policy, World Health Organisation, CH-1211 Geneva 27, Switzerland 14: The Center for Health Services Research in Primary Care, HSR&D, Department of Veterans Affairs Medical Center and Duke University Medical Center, 508 Fulton St., Durham, NC 27705, USA; Source Info: 2004, Vol. 4, p38; Subject Term: MEDICAL research; Subject Term: EVIDENCE-based medicine; Subject Term: DECISION making in clinical medicine; Subject Term: MEDICINE -- Practice; Subject Term: EVIDENCE-based management; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1186/1472-6963-4-38
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mauldin, Joyce
AU - Cameron, H. Dan
AU - Jeanotte, Diane
AU - Solomon, Glenn
AU - Jarvis, James N.
T1 - Chronic arthritis in children and adolescents in two Indian health service user populations.
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
Y1 - 2004/01//
VL - 5
M3 - Article
SP - 30
EP - 7
PB - BioMed Central
SN - 14712474
AB - Background: High prevalence rates for rheumatoid arthritis, spondyloarthopathies, and systemic lupus erythematosus have been described in American Indian and Alaskan Native adults. The impact of these diseases on American Indian children has not been investigated. Methods: We used International Classification of Diseases-9 (ICD-9) codes to search two Indian Health Service (IHS) patient registration databases over the years 1998--2000, searching for individuals 19 years of age or younger with specific ICD-9-specified diagnoses. Crude estimates for disease prevalence were made based on the number of individuals identified with these diagnoses within the database. Results: Rheumatoid arthritis (RA) / juvenile rheumatoid arthritis (JRA) was the most frequent diagnosis given. The prevalence rate for JRA in the Oklahoma City Area was estimated as 53 per 100,000 individuals at risk, while in the Billings Area, the estimated prevalence was nearly twice that, at 115 per 100,000. These rates are considerably higher than those reported in the most recent European studies. Conclusion: Chronic arthritis in childhood represents an important, though unrecognized, chronic health challenge within the American Indian population living in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Musculoskeletal Disorders is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHEUMATOID arthritis
KW - PATIENTS
KW - INDIGENOUS peoples of the Americas
KW - DIAGNOSIS
KW - DATABASES
KW - DISEASE prevalence
KW - UNITED States
N1 - Accession Number: 29438360; Mauldin, Joyce 1,2; Email Address: jmauldin@ihs.gov Cameron, H. Dan 3; Email Address: dcameron@ihs.gov Jeanotte, Diane 4; Email Address: djeanotte@ihs.gov Solomon, Glenn 1,5; Email Address: glenn-solomon@ouhsc.edu Jarvis, James N. 1; Email Address: james-jarvis@ouhsc.edu; Affiliation: 1: Dept. of Pediatrics, University of Oklahoma College of Medicine, BSEB #235A, Oklahoma City, OK, 73104 USA 2: Oklahoma City Area Indian Health Service, Five Corporate Plaza, 3625 NW 56th Street, Oklahoma City, OK, 73112 USA 3: Oklahoma City Area Indian Health Service, Five Corporate Plaza, 3625 NW 56th Street Oklahoma City, OK, 73112 USA 4: Billings Area Indian Health Service, 2900 4th Avenue North, Billings, MT 59101 USA 5: Arthritis & Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104 USA; Source Info: 2004, Vol. 5, p30; Subject Term: RHEUMATOID arthritis; Subject Term: PATIENTS; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: DIAGNOSIS; Subject Term: DATABASES; Subject Term: DISEASE prevalence; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1471-2474-5-30
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, Hollie V.
AU - Thomas, Daniel Rh.
AU - Salmon, Roland L.
AU - Lewis, Glyn
AU - Smith, Andy P.
T1 - Toxoplasma and coxiella infection and psychiatric morbidity: A retrospective cohort analysis.
JO - BMC Psychiatry
JF - BMC Psychiatry
Y1 - 2004/01//
VL - 4
M3 - Article
SP - 32
EP - 5
PB - BioMed Central
SN - 1471244X
AB - Background: It has been suggested that infection with Toxoplasma gondii is associated with slow reaction and poor concentration, whilst infection with Coxiella burnetii may lead to persistent symptoms of fatigue. Methods: 425 farmers completed the Revised Clinical Interview Schedule (CIS-R) by computer between March and July 1999 to assess psychiatric morbidity. Samples of venous blood had been previously collected and seroprevalence of T. gondii and C. burnetii was assessed. Results: 45% of the cohort were seropositive for T. gondii and 31% were positive for C. burnetii. Infection with either agent was not associated with symptoms reflecting clinically relevant levels of concentration difficulties, fatigue, depression, depressive ideas or overall psychiatric morbidity. Conclusions: We do not provide any evidence that infection with Toxoplasma gondii or Coxiella burnetii is associated with neuropsychiatric morbidity, in particular with symptoms of poor concentration or fatigue. However, this is a relatively healthy cohort with few individuals reporting neuropsychiatric morbidity and therefore the statistical power to test the study hypotheses is limited. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Psychiatry is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFECTION
KW - TOXOPLASMA gondii
KW - COXIELLA burnetii
KW - MENTAL illness
KW - FARMERS -- Health
KW - ATTENTION
KW - MENTAL fatigue
N1 - Accession Number: 29323673; Thomas, Hollie V. 1; Email Address: thomashv@cardiff.ac.uk Thomas, Daniel Rh. 2; Email Address: daniel.thomas@nphs.wales.nhs.uk Salmon, Roland L. 1; Email Address: Roland.Salmon@nphs.wales.nhs.uk Lewis, Glyn 3; Email Address: Glyn.Lewis@bristol.ac.uk Smith, Andy P. 4; Email Address: Smithap@cardiff.ac.uk; Affiliation: 1: Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK 2: Communicable Disease Surveillance Centre, National Public Health Service, Wedal Road, Cardiff, UK 3: Division of Psychiatry, University of Bristol, Cotham Hill, Bristol, UK 4: Centre for Occupational and Health Psychology, School of Psychology, Cardiff University, Cardiff, UK; Source Info: 2004, Vol. 4, p32; Subject Term: INFECTION; Subject Term: TOXOPLASMA gondii; Subject Term: COXIELLA burnetii; Subject Term: MENTAL illness; Subject Term: FARMERS -- Health; Subject Term: ATTENTION; Subject Term: MENTAL fatigue; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1186/1471-244X-4-32
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hingorani, Sunil R.
AU - Petricoin III, Emanuel F.
AU - Maitra, Anirban
AU - Rajapakse, Vinodh
AU - King, Catrina
AU - Jacobetz, Michael A.
AU - Ross, Sally
AU - Conrads, Thomas P.
AU - Veenstra, Timothy D.
AU - Hitt, Ben A.
AU - Kawaguchi, Yoshiya
AU - Johann, Don
AU - Liotta, Lance A.
AU - Crawford, Howard C.
AU - Putt, Mary E.
AU - Jacks, Tyler
AU - Wright, Christopher V.E.
AU - Hruban, Ralph H.
AU - Lowy, Andrew M.
AU - Tuveson, David A.
T1 - Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
JO - Cancer Cell
JF - Cancer Cell
Y1 - 2004/01//
VL - 5
IS - 1
M3 - Correction notice
SP - 103
SN - 15356108
N1 - Accession Number: 12039158; Hingorani, Sunil R. 1,2 Petricoin III, Emanuel F. 3 Maitra, Anirban 4 Rajapakse, Vinodh 5 King, Catrina 2 Jacobetz, Michael A. 2 Ross, Sally 5 Conrads, Thomas P. 6 Veenstra, Timothy D. 6 Hitt, Ben A. 7 Kawaguchi, Yoshiya 8 Johann, Don 5 Liotta, Lance A. 5 Crawford, Howard C. 9 Putt, Mary E. 10 Jacks, Tyler 11 Wright, Christopher V.E. 8 Hruban, Ralph H. 4 Lowy, Andrew M. 12 Tuveson, David A. 1,2; Email Address: tuvesond@mail.med.upenn.edu; Affiliation: 1: Department of Medicine, Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA 19104 USA 2: Department of Cancer Biology, Abramson Family Cancer Research Institute, Abramson Cancer Center at the University of Pennsylvania, Philadelphia, PA 19104 USA 3: FDA-NCI Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 USA 4: Departments of Pathology and Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA 5: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892 USA 6: National Cancer Institute Biomedical Proteomics Program, Analytical Chemistry Laboratory, Mass Spectrometry Center, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702 USA 7: Correlogic Systems, Inc., Bethesda, MD 20892 USA 8: Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 USA 9: Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 USA 10: Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 USA 11: Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA 02139 USA 12: Department of Surgery, Division of Surgical Oncology, University of Cincinnati College of Medicine, Cincinnati, OH 45219 USA; Source Info: Jan2004, Vol. 5 Issue 1, p103; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/S1535-6108(03)00309-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12039158&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Powers, John H.
AU - Cooper, Charles K.
T1 - Evaluating Combination Therapy in Community-Acquired Pneumonia.
JO - CHEST
JF - CHEST
Y1 - 2004/01//
VL - 125
IS - 1
M3 - Letter
SP - 353
EP - 353
PB - American College of Chest Physicians
SN - 00123692
AB - Presents a letter to the editor commenting on the research of Brown and colleagues related to the evaluation of combination therapy in community-acquired pneumonia previously published in May 2003.
KW - LETTERS to the editor
KW - PNEUMONIA -- Treatment
N1 - Accession Number: 11973034; Powers, John H. 1; Email Address: POWERSJOH@cder.fda.gov Cooper, Charles K. 1; Affiliation: 1: Center for Drug Evaluation and Research, United States Food and Drug Administration, MD; Source Info: Jan2004, Vol. 125 Issue 1, p353; Subject Term: LETTERS to the editor; Subject Term: PNEUMONIA -- Treatment; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McComas, Katherine
AU - Waks, Leah
AU - Simone, Leah
AU - Sherman, Linda
T1 - Predicting Satisfaction and Outcome Acceptance with Decision-Making Processes: The Role of Procedural Justice.
JO - Conference Papers -- International Communication Association
JF - Conference Papers -- International Communication Association
Y1 - 2004///2004 Annual Meeting
M3 - Article
SP - 1
PB - International Communication Association
AB - Maintaining the legitimacy of decision making processes in the eyes of participants is a key objective of creditable public involvement efforts; however, satisfying participants can be difficult, especially when competing interests are at stake. Research suggests that attention to procedural justice may offer one way to increase satisfaction and outcome acceptance. Procedural justice argues that people care about the fairness of the procedures, and research has shown that when procedures are viewed as fair, people are more satisfied with the process and accepting of the outcomes - at times, even when they do not get the outcomes they desire. Using survey data from attendees at 11 U.S. Food and Drug Administration advisory committee meetings, we tested whether procedural justice judgments predicted satisfaction with the FDA and its advisory committees and acceptance of advisory committee meeting outcomes. We also examined how contextual factors - namely, procedural knowledge, tolerance for potential conflicts of interest among advisory committee members, and participants' stakes in the outcomes, influenced the results. The findings supported a strong role for procedural justice perceptions in predicting satisfaction and outcome acceptance among meeting attendees. ..PAT.-Unpublished Manuscript [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- International Communication Association is the property of International Communication Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - conflict of interest
KW - group decision making
KW - procedural justice
KW - relational judgments
KW - satisfaction
N1 - Accession Number: 45283554; McComas, Katherine 1; Email Address: kam19@cornell.edu; Waks, Leah 2; Email Address: leahwaks@wam.umd.edu; Simone, Leah 2; Email Address: lsimone@erols.com; Sherman, Linda 3; Email Address: lsherman@oc.fda.gov; Affiliations: 1: Cornell University; 2: U of Maryland; 3: U.S. Food and Drug Administration; Issue Info: 2004 Annual Meeting, p1; Author-Supplied Keyword: conflict of interest; Author-Supplied Keyword: group decision making; Author-Supplied Keyword: procedural justice; Author-Supplied Keyword: relational judgments; Author-Supplied Keyword: satisfaction; Number of Pages: 35p; Document Type: Article
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DP - EBSCOhost
DB - ufh
ER -
TY - CHAP
ID - 2005-01253-015
AN - 2005-01253-015
AU - Itzhak, Yossef
AU - Anderson, Karen L.
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
ED - Ali, Syed F., (Ed)
ED - Nabeshima, Toshitaka, (Ed)
ED - Yanagita, Tomoji, (Ed)
T1 - Differential Response of nNOS Knockout Mice to MDMA ('Ecstasy')- and Methamphetamine-Induced Psychomotor Sensitization and Neurotoxicity.
T2 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
SP - 119
EP - 128
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - Itzhak, Yossef, Department of Psychiatry & Behavioral Sciences, University of Miami School of Medicine, 1011 NW 15th Street, Gautier Building 503, Miami, FL, US, 33136
N1 - Accession Number: 2005-01253-015. Partial author list: First Author & Affiliation: Itzhak, Yossef; Department of Psychiatry and Behavioral Science, University of Miami School of Medicine, Miami, FL, US. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Major Descriptor: Drug Sensitivity; Methamphetamine; Methylenedioxymethamphetamine; Mice; Neurotoxicity. Minor Descriptor: CNS Stimulating Drugs; Dopamine; Genes; Nitric Oxide; Sensitization; Serotonin. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10.
AB - It has been shown that mice deficient in neuronal nitric oxide synthase (nNOS) gene are resistant to cocaine-induced psychomotor sensitization and methamphetamine (METH)-induced dopaminergic neurotoxicity. The present study was undertaken to investigate the hypothesis that nNOS has a major role in dopamine (DA)--but not serotonin (5-hydroxytryptamine; 5-HT)-mediated effects of psychostimulants. The response of nNOS knockout (KO) and wild-type (WT) mice to the psychomotor-stimulating and neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') and METH were investigated. Repeated administration of MDMA for 5 days resulted in psychomotor sensitization in both WT and nNOS KO mice, while repeated administration of METH caused psychomotor sensitization in WT but not in KO mice. Sensitization to both MDMA and METH was persistent for 40 days in WT mice, but not in nNOS KO mice. These findings suggest that the induction of psychomotor sensitization to MDMA and METH is NO independent and NO dependent, respectively, while the persistence of sensitization to both drugs is NO dependent. For the neurochemical studies, a high dose of MDMA caused marked depletion of 5-HT in several brain regions of both WT and KO mice, suggesting that the absence of the nNOS gene did not afford protection against MDMA-induced depletion of 5-HT. Striatal dopaminergic neurotoxicity caused by high doses of MDMA and METH in WT mice was partially prevented in KO mice administered with MDMA, but it was fully precluded in KO mice administered with METH. The differential response of nNOS KO mice to the behavioral and neurotoxic effects of MDMA and METH suggests that the nNOS gene is required for the expression and persistence of DA-mediated effects of METH and MDMA, while 5-HT-mediated effects of MDMA (induction of sensitization and 5-HT depletion) are not dependent on nNOS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mice
KW - MDMA
KW - ecstasy
KW - methamphetamine
KW - psychostimulants
KW - psychomotor sensitization
KW - dopaminergic neurotoxicity
KW - dopamine
KW - serotonin
KW - nitric oxide synthase gene
KW - 2004
KW - Drug Sensitivity
KW - Methamphetamine
KW - Methylenedioxymethamphetamine
KW - Mice
KW - Neurotoxicity
KW - CNS Stimulating Drugs
KW - Dopamine
KW - Genes
KW - Nitric Oxide
KW - Sensitization
KW - Serotonin
KW - 2004
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UR - yitzhak@med.miami.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-01253-033
AN - 2005-01253-033
AU - Virmani, Ashraf
AU - Gaetani, Franco
AU - Binienda, Zbigniew
AU - Xu, Alex
AU - Duhart, Helen
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
ED - Ali, Syed F., (Ed)
ED - Nabeshima, Toshitaka, (Ed)
ED - Yanagita, Tomoji, (Ed)
T1 - Role of Mitochondrial Dysfunction in Neurotoxicity of MPP+: Partial Protection of PC12 Cells by Acetyl-L-Carnitine.
T2 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
SP - 267
EP - 273
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - Virmani, Ashraf, Sigma-tau HealthScience S.p.A., Pomezia, Italy, 00040
N1 - Accession Number: 2005-01253-033. Partial author list: First Author & Affiliation: Virmani, Ashraf; Sigma-tau HealthScience S.p.A., Pomezia, Italy. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Major Descriptor: Metabolites; Methamphetamine; Methylphenyltetrahydropyridine; Neurotoxicity; Rats. Minor Descriptor: Dopamine; Neurons; Neurotoxins; Mitochondria. Classification: Psychopharmacology (2580). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7.
AB - The damage to the central nervous system that is observed after administration of either methamphetamine (METH) or 1-methyl-4-phenylpyridinium (MPP+), the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is known to be linked to dopamine (DA). The underlying neurotoxicity mechanism for both METH and MPP+ seem to involve free radical formation and impaired mitochondrial function. The MPP+ is thought to selectively kill nigrostriatal dopaminergic neurons by inhibiting mitochondrial complex I, with cell death being attributed to oxidative stress damage to these vulnerable DA neurons. In the present study, MPP+ was shown to significantly inhibit the response to MTT by cultured PC12 cells. This inhibitory action of MPP+ could be partially reversed by the co-incubation of the cells with the acetylated form of carnitine, acetyl-L-carnitine (ALC). Since at least part of the toxic action of MPP+ is related to mitochondrial inhibition, the partial reversal of the inhibition of MTT response by ALC could involve a partial restoration of mitochondrial function. The role carnitine derivatives, such as ALC, play in attenuating MPP+ and METH-evoked toxicity is still under investigation to elucidate the contribution of mitochondrial dysfunction in mechanisms of neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rats
KW - neurotoxicity
KW - neurotoxins
KW - methamphetamine
KW - dopamine
KW - neurons
KW - mitochondrial dysfunction
KW - MPP+
KW - MPTP
KW - 2004
KW - Metabolites
KW - Methamphetamine
KW - Methylphenyltetrahydropyridine
KW - Neurotoxicity
KW - Rats
KW - Dopamine
KW - Neurons
KW - Neurotoxins
KW - Mitochondria
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01253-033&site=ehost-live&scope=site
UR - ashraf.virmani@st-hs.it
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-01253-051
AN - 2005-01253-051
AU - Pereira, Frederico C.
AU - Santos, Sandra D.
AU - Ribeiro, Carlos F.
AU - Ali, Syed F.
AU - Macedo, Tice R.
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
ED - Ali, Syed F., (Ed)
ED - Nabeshima, Toshitaka, (Ed)
ED - Yanagita, Tomoji, (Ed)
T1 - A Single Exposure to Morphine Induces Long-Lasting Hyporeactivity of Rat Caudate Putamen Dopaminergic Nerve Terminals.
T2 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
SP - 414
EP - 423
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - Pereira, Frederico C., Instituto de Farmacologia e Terapeutica, Medical School, University of Coimbra, Coimbra, Portugal, 3004-504
N1 - Accession Number: 2005-01253-051. Partial author list: First Author & Affiliation: Pereira, Frederico C.; Instituto de Farmacologia e Terapêutica, University of Coimbra Medical School, Coimbra, Portugal. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Major Descriptor: Dopamine; Morphine; Putamen; Rats. Minor Descriptor: Caudate Nucleus; Neurochemistry. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10.
AB - The long-lasting effects of exposure to drugs of abuse on the brain is a central theme in drug addiction research. This study was designed to evaluate whether enduring neurochemical adaptations within caudate putamen can be evoked by a single injection of a high dose of morphine. Rats were pretreated once with 10 mg/kg morphine. Seven days later the effect of another injection of 10 mg/kg morphine on total levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanilic acid (HVA) in caudate putamen was assessed in half the pretreated animals. An irreversible μ-opioid receptor antagonist, cloccinamox (C-CAM; 0.1 mg/kg), significantly antagonized the elevation of the HVA/DA ratio, but not the elevation of the DOPAC/DA ratio induced by morphine in the caudate putamen from drug-naive animals. Pretreatment with morphine blunted changes in the HVA/DA ratio induced by another morphine challenge, but it had no effect on the DOPAC/DA ratio within the caudate putamen. Therefore, a single dose of 10 mg/kg morphine hampered nigrostriatal DA release and extraneuronal metabolism, μ-opioid receptor mediated, on another 10 mg/kg morphine challenge. This confirms that the first exposure to morphine does not go without long-lasting neurochemical adaptations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - morphine
KW - dopamine
KW - neurochemical adaptations
KW - caudate putamen
KW - rats
KW - 2004
KW - Dopamine
KW - Morphine
KW - Putamen
KW - Rats
KW - Caudate Nucleus
KW - Neurochemistry
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01253-051&site=ehost-live&scope=site
UR - fredcp@ci.uc.pt
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-01253-067
AN - 2005-01253-067
AU - Dass, S. Balachandra
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
ED - Ali, Syed F., (Ed)
ED - Nabeshima, Toshitaka, (Ed)
ED - Yanagita, Tomoji, (Ed)
T1 - Evaluation of γ-Hydroxybutyric Acid for Genotoxicity in the Mouse Micronucleus Assay.
T2 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
SP - 538
EP - 542
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - Dass, S. Balachandra, Merck Research Laboratories, Mail Code RY34B-364, 126 East Lincoln Avenue, Rahway, NJ, US, 07065
N1 - Accession Number: 2005-01253-067. Partial author list: First Author & Affiliation: Dass, S. Balachandra; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Major Descriptor: Acids; Cell Nucleus; CNS Depressant Drugs; Genes; Toxicity. Minor Descriptor: Mice. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5.
AB - γ-Hydroxybutyric acid (GHB) is an endogenous compound found in the brain and other tissues of mammals. Neurotransmitter/neuromodulator functions have been ascribed to GHB, which has lately become a drug of abuse. In this study, we tested GHB for genotoxicity by measuring its ability to induce micronuclei in polychromatic erythrocytes (reticulocytes) in the peripheral blood of mice. Intraperitoneal injection with a dose of 25 mg/kg/day for 3 days or 50 mg/kg/day × 3 days resulted in a significant (by Dunnett's test) increase of 1.9- to 2.1-fold in micronuclei. However, because increases were small and because no consistent dose-dependent increase in induced micronuclear frequency could be demonstrated, our results do not conclusively show that GHB is an in vivo genotoxicant in mammals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gamma hydroxybutyric acid
KW - genotoxicity
KW - micronucli
KW - mice
KW - 2004
KW - Acids
KW - Cell Nucleus
KW - CNS Depressant Drugs
KW - Genes
KW - Toxicity
KW - Mice
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01253-067&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-01253-068
AN - 2005-01253-068
AU - Riegel, A.C.
AU - Ali, S.F.
AU - Torinese, S.
AU - French, E.D.
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
ED - Ali, Syed F., (Ed)
ED - Nabeshima, Toshitaka, (Ed)
ED - Yanagita, Tomoji, (Ed)
T1 - Repeated Exposure to the Abused Inhalant Toluene Alters Levels of Neurotransmitters and Generates Peroxynitrite in Nigrostriatal and Mesolimbic Nuclei in Rat.
T2 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
SP - 543
EP - 551
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - French, E.D., Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, US, 85724-5050
N1 - Accession Number: 2005-01253-068. Partial author list: First Author & Affiliation: Riegel, A.C.; Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, US. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Major Descriptor: Chemicals; Dopamine; Serotonin; Toluene. Minor Descriptor: Caudate Nucleus; Neurotoxicity; Neurotransmitters; Nitric Oxide; Nucleus Accumbens; Rats; Substantia Nigra; Tegmentum. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9.
AB - Toluene, a volatile hydrocarbon found in a variety of chemical compounds, is misused and abused by inhalation for its euphorigenic effects. Toluene's reinforcing properties may share a common characteristic with other drugs of abuse, namely, activation of the mesolimbic dopamine system. Prior studies in our laboratory found that acutely inhaled toluene activated midbrain dopamine neurons in the rat. Moreover, single systemic injections of toluene in rats produced a dose-dependent increase in locomotor activity which was blocked by depletion of nucleus accumbens dopamine or by pretreatment with a D2 dopamine receptor antagonist. Here we examined the effects of seven daily intraperitoneal injections of 600 mg/kg toluene on the content of serotonin and dopamine in the caudate nucleus (CN) and nucleus accumbens (NAC), substantia nigra, and ventral tegmental area at 2, 4, and 24 h after the last injection. Also, the roles of nitric oxide, peroxynitrite, and the production of 3-nitrosotyrosine (3-NT), in the CN and NAC were assessed at the same time points. Toluene treatments increased dopamine levels in the CN and NAC, and serotonin levels in CN, NAC, and ventral tegmental area. Measurements of the dopamine metabolite dihydroxyphenylacetic acid (DOPAC) further suggested a change in transmitter utilization in CN and NAC. Lastly, 3-NT levels also showed a differential change between CN and NAC, but at different time points post-toluene injection. These results point out the complexity of action of toluene on neurotransmitter function following a course of chronic exposure. Changes in the production of 3-NT also suggest that toluene-induced neurotoxicity may mediate via generation of peroxynitrite. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - toluene
KW - rats
KW - neurotransmitters
KW - serotonin
KW - dopamine
KW - caudate nucleus
KW - nucleus accumbens
KW - substantia nigra
KW - ventral tegmental area
KW - nitric oxide
KW - peroxynitrite
KW - nitrosotyrosine
KW - 2004
KW - Chemicals
KW - Dopamine
KW - Serotonin
KW - Toluene
KW - Caudate Nucleus
KW - Neurotoxicity
KW - Neurotransmitters
KW - Nitric Oxide
KW - Nucleus Accumbens
KW - Rats
KW - Substantia Nigra
KW - Tegmentum
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01253-068&site=ehost-live&scope=site
UR - efrench@email.arizona.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chin, Marshall H.
AU - Cook, Sandy
AU - Drum, Melinda L.
AU - Jin, Lei
AU - Guillen, Myriam
AU - Humikowski, Catherine A.
AU - Koppert, Julie
AU - Harrison, James F.
AU - Lippold, Susan
AU - Schaefer, Cynthia T.
T1 - Improving Diabetes Care in Midwest Community Health Centers With the Health Disparities Collaborative.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2004/01//
VL - 27
IS - 1
M3 - Article
SP - 2
EP - 8
SN - 01495992
AB - OBJECTIVE — To evaluate the Diabetes Health Disparities Collaborative, an initiative by the Bureau of Primary Health Care to reduce health disparities and improve the quality of diabetes care in community health centers. RESEARCH DESIGN AND METHODS — One year before after trial. Beginning in 1998, 19 Midwestern health centers undertook a diabetes quality improvement initiative based on a model including rapid Plan-Do-Study-Act cycles from the continuous quality improvement field; a Chronic Care Model emphasizing patient sell-management, delivery system redesign, decision support, clinical information systems, leadership, health system organization, and community outreach; and collaborative learning sessions. We reviewed charts of 969 random adults for American Diabetes Association standards, surveyed 79 diabetes quality improvement team members, and performed qualitative interviews. RESULTS — The performance of several key processes of care assessed by chart review increased, including rates of HbA[sub 1c] measurement (80-90%; adjusted odds ratio 2.1, 95% Cl 1.6-2.8), eye examination referral (36-47%; 1.6, 1.1-2.3), foot examination (40-64%; 2.7, 1.8-4.1), and lipid assessment (55-66%; 1.6, 1.1-2.3). Mean value of HbA[sup 1c] tended to improve (8.5-8.3%; difference -0.2, 95% CI -0.4 to 0.03). Over 90% of survey respondents stated that the Diabetes Collaborative was worth the effort and was successful. Major challenges included needing more time and resources, initial difficulty developing computerized patient registries, team and staff turnover, and occasional need for more support by senior management. CONCLUSIONS — The Health Disparities Collaborative improved diabetes care in health centers in 1 year. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - PRIMARY health care
KW - REGIONAL disparities
KW - QUALITY of life
KW - PUBLIC health
KW - COMMUNITY centers
N1 - Accession Number: 11829503; Chin, Marshall H. 1; Email Address: mchin@medicine.bsd.uchicago.edu Cook, Sandy 1 Drum, Melinda L. 1 Jin, Lei 1 Guillen, Myriam 1 Humikowski, Catherine A. 1 Koppert, Julie 2 Harrison, James F. 3,4 Lippold, Susan 5,6 Schaefer, Cynthia T. 7; Affiliation: 1: Departments of Medicine and Health Studies, Diabetes Research and Training Center, The University of Chicago, Chicago, Illinois 2: Midwest Cluster Health Disparities Collaborative, Kenton, Ohio 3: North Woods Community Health Center, Minong, Wisconsin 4: South Lane Medical Group, Cottage Grove, Oregon 5: Health Resources and Services Administration, Chicago, Illinois 6: Centers for Disease Control City of Chicago Tuberculosis Program, Chicago, Illinois 7: Department of Nursing and Health Sciences, University of Evansville, Evansville, Indiana; Source Info: Jan2004, Vol. 27 Issue 1, p2; Subject Term: DIABETES; Subject Term: PRIMARY health care; Subject Term: REGIONAL disparities; Subject Term: QUALITY of life; Subject Term: PUBLIC health; Subject Term: COMMUNITY centers; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 5774
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patrick, Mary E.
AU - Adcock, Penny M.
AU - Gomez, Thomas M.
AU - Altekruse, Sean F.
AU - Holland, Ben H.
AU - Tauxe, Robert V.
AU - Swerdlow, David L.
T1 - Salmonella Enteritidis Infections, United States, 1985-1999.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/01//
VL - 10
IS - 1
M3 - Article
SP - 1
EP - 7
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Salmonella enterica serotype Enteritidis emerged as an important illness during the 1980s. Investigations showed that consumption of undercooked eggs was the major risk factor for disease, and a variety of prevention and control efforts were initiated during the 1990s. We describe sporadic infections and outbreaks of S. Enteritidis in the United States from 1985 through 1999 and discuss prevention and control efforts. After reaching a high of 3.9 per 100,000 population in 1995, S. Enteritidis infections declined to 1.98 per 100,000 in 1999. While the total number of outbreaks decreased by half, those in the western states tripled. Outbreaks of S. Enteritidis phage type 4 infections accounted for 49% of outbreaks in 1999. Outbreak-associated deaths in health facilities decreased from 14 in 1987 to 0 in 1999. Overall, rates of sporadic S. Enteritidis infection, outbreaks, and deaths have declined dramatically. For further reductions, control measures should continue to be applied along the entire farm-to-table continuum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Foodborne diseases
KW - Communicable diseases
KW - Diseases
KW - Health facilities
N1 - Accession Number: 11870196; Patrick, Mary E. 1,2; Email Address: mcevans@gdph.state.ga.us; Adcock, Penny M. 2,3; Gomez, Thomas M. 4; Altekruse, Sean F. 5; Holland, Ben H. 2,6; Tauxe, Robert V. 2; Swerdlow, David L. 2; Affiliations: 1: DeKalb County Board of Health, Decatur, Georgia, USA; 2: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: Merck Research Laboratories, Blue Bell, Pennsylvania, USA; 4: U.S. Department of Agriculture, Atlanta, Georgia, USA; 5: Food and Drug Administration, Rockville, Maryland, USA; 6: Mercer University School of Medicine, Macon, Georgia, USA; Issue Info: Jan2004, Vol. 10 Issue 1, p1; Thesaurus Term: Salmonella; Thesaurus Term: Foodborne diseases; Thesaurus Term: Communicable diseases; Thesaurus Term: Diseases; Subject Term: Health facilities; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chapin, Robert E.
AU - Robbins, Wendie A.
AU - Schieve, Laura A.
AU - Sweeney, Anne M.
AU - Tabacova, Sonia A.
AU - Tomashek, Kay M.
T1 - Off to a Good Start: The Influence of Pre- and Periconceptional Exposures, Parental Fertility, and Nutrition on Children's Health.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/01//
VL - 112
IS - 1
M3 - Article
SP - 69
EP - 78
PB - Superintendent of Documents
SN - 00916765
AB - The scientific community is developing a compelling body of evidence that shows the importance of the in utero environment (including chemical and hormonal levels) to the ultimate health of the child and even of the aging adult. This article summarizes the evidence that shows this impact begins with conception. Only a full life-cycle evaluation will help us understand these impacts, and only such an understanding will produce logically prioritized mitigation strategies to address the greatest threats first. Clearly, the time for analysis begins when the next generation is but a twinkle in the eye. Key words: birth defects; chemical exposure; conception; fertilization; review. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Human fertility
KW - Nutrition
KW - Pollution
KW - Hormones
KW - Children
KW - Conception
N1 - Accession Number: 12122635; Chapin, Robert E. 1; Email Address: robert_e_chapin@groton.pfizer.com; Robbins, Wendie A. 2; Schieve, Laura A. 3; Sweeney, Anne M. 4; Tabacova, Sonia A. 5; Tomashek, Kay M. 6; Affiliations: 1: Pfizer Global Research and Development, Safety Sciences, Connecticut, USA; 2: UCLA Center for Occupational and Environmental Health, University of California at Los Angeles, USA; 3: Division of Reproductive Health, Centers for Disease Control and Prevention, Georgia, USA; 4: Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University System Health Science Center, USA; 5: National Center for Toxicological Research, U.S. Food and Drug Administration, Maryland, USA; 6: Maternal and Infant Health Branch, Centers for Disease Control and Prevention, Georgia, USA; Issue Info: Jan2004, Vol. 112 Issue 1, p69; Thesaurus Term: HEALTH; Thesaurus Term: Human fertility; Thesaurus Term: Nutrition; Thesaurus Term: Pollution; Thesaurus Term: Hormones; Subject Term: Children; Subject Term: Conception; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12122635&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buck, Germaine M.
AU - Lynch, Courtney D.
AU - Stanford, Joseph B.
AU - Sweeney, Anne M.
AU - Schieve, Laura A.
AU - Rockett, John C.
AU - Selevan, Sherry G.
AU - Schrader, Steven M.
T1 - Prospective Pregnancy Study Designs for Assessing Reproductive and Developmental Toxicants.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/01//
VL - 112
IS - 1
M3 - Article
SP - 79
EP - 86
PB - Superintendent of Documents
SN - 00916765
AB - The determinants of successful human reproduction and development may act as early as periconceptionally, underscoring the need to capture exposures during these critical windows when assessing potential toxicants. To identify such toxicants, couples must be studied longitudinally prior to conception without regard to a couple's ability to ascertain a clinically recognized pregnancy. We examined the utility and feasibility of prospective pregnancy study designs by conducting a systematic review of the literature to summarize relevant information regarding the planning, implementation, and success of previously published prospective pregnancy studies. Information concerning design elements and participation was abstracted from 15 eligible studies (from a total of 20 identified studies) using a standardized form. The primary author of each study was contacted to review our summary of their work and obtain missing information. Our findings confirm the ability to recruit women/couples from diverse populations using a variety of recruitment strategies. Among the studies we reviewed, 4-97% of eligible individuals were successfully contacted, with enrollment rates ranging from 42 to 100%. Length of follow-up varied from 3 to 12 months. A high percentage of women provided urine (57-98%) and blood (86-91%) specimens and most male partners (94-100%) provided semen samples. These data support the feasibility of this design. Key words: design; development; fetal; preconception; pregnancy; prospective; reproduction; toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisons
KW - Reproductive toxicology
KW - Developmental toxicology
KW - Pregnancy
KW - Conception
KW - Preconception care
N1 - Accession Number: 12122639; Buck, Germaine M. 1; Email Address: gb156i@nih.gov; Lynch, Courtney D. 1; Stanford, Joseph B. 2; Sweeney, Anne M. 3; Schieve, Laura A. 4; Rockett, John C. 5; Selevan, Sherry G. 6; Schrader, Steven M. 7; Affiliations: 1: Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Maryland, USA; 2: Department of Family Preventive Medicine, Health Research Center, University of Utah, USA; 3: Department of Epidemiology, Texas A&M University Health Science Center, School of Rural Public Health, USA; 4: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Georgia, USA; 5: Gamete and Early Embryo Research Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, North Carolina, USA; 6: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA; 7: Reproductive Health Assessment Section, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Ohio, USA; Issue Info: Jan2004, Vol. 112 Issue 1, p79; Thesaurus Term: Poisons; Subject Term: Reproductive toxicology; Subject Term: Developmental toxicology; Subject Term: Pregnancy; Subject Term: Conception; Subject Term: Preconception care; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12122639&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Whipkey, Diana L.
AU - Weston, Ainsley
T1 - The effect of oxythioquinox exposure on normal human mammary epithelial cell gene expression: A microarray analysis study.
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
Y1 - 2004/01//
VL - 3
M3 - Article
SP - 9
EP - 11
PB - BioMed Central
SN - 1476069X
AB - Background: Inter-individual variation in normal human mammary epithelial cells in response to oxythioquinox (OTQ) is reported. Gene expression signatures resulting from chemical exposures are generally created from analysis of exposures in rat, mouse or other genetically similar animal models, limiting information about inter-individual variations. This study focused on the effect of inter-individual variation in gene expression signatures. Methods: Gene expression was studied in primary normal human mammary epithelial cells (NHMECs) derived from four women undergoing reduction mammoplasty [Cooperative Human Tissue Network (National Cancer Institute and National Disease Research Interchange)]. Gene transcription in each cell strain was analyzed using high-density oligonucleotide DNA microarrays (HuGeneFL, Affymetrix™) and changes in the expression of selected genes were verified by realtime polymerase chain reaction at extended time points (ABI). DNA microarrays were hybridized to materials prepared from total RNA that was collected after OTQ treatment for 15, 60 and 120 min. RNA was harvested from the vehicle control (DMSO) at 120 min. The gene expression profile included all genes altered by at least a signal log ratio (SLR) of ± 0.6 and p value ≤ 0.05 in three of four cell strains analyzed. Results: RNA species were clustered in various patterns of expression highlighting genes with altered expression in one or more of the cell strains, including metabolic enzymes and transcription factors. Of the clustered RNA species, only 36 were found to be altered at one time point in three or more of the cell strains analyzed (13 up-regulated, 23 down-regulated). Cluster analysis examined the effects of OTQ on the cells with specific p53 polymorphisms. The two strains expressing the major variant of p53 had 83 common genes altered (35 increased, 48 decreased) at one or more time point by at least a 0.6 signal log ratio (SLR). The intermediate variant strains showed 105 common genes altered (80 increased, 25 decreased) in both strains. Conclusion: Differential changes in expression of these genes may yield biomarkers that provide insight into inter-individual variation in cancer risk. Further, specific individual patterns of gene expression may help to determine more susceptible populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIAL cells
KW - CHEMICALS
KW - GENE expression
KW - RATS as laboratory animals
KW - MAMMAPLASTY
KW - GENETIC transcription
KW - DNA microarrays
KW - OLIGONUCLEOTIDES
N1 - Accession Number: 28742655; Gwinn, Maureen R. 1; Email Address: mwg9@cdc.gov Whipkey, Diana L. 2; Email Address: drw9@cdc.gov Weston, Ainsley 2; Email Address: agw8@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mail Stop #L-2015, Morgantown, WV 26505-2888 USA 2: Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mail Stop #L-3014, Morgantown, WV 26505-2888 USA; Source Info: 2004, Vol. 3, p9; Subject Term: EPITHELIAL cells; Subject Term: CHEMICALS; Subject Term: GENE expression; Subject Term: RATS as laboratory animals; Subject Term: MAMMAPLASTY; Subject Term: GENETIC transcription; Subject Term: DNA microarrays; Subject Term: OLIGONUCLEOTIDES; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1186/1476-069X-3-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garber, Eric A. E.
AU - Erb, Judith L.
AU - Magner, Joseph
AU - Larsen, Gerald
T1 - Low Levels of Sodium and Potassium in the Water from Wetlands in Minnesota that Contained Malformed Frogs Affect the Rate of Xenopus Development.
JO - Environmental Monitoring & Assessment
JF - Environmental Monitoring & Assessment
Y1 - 2004/01//
VL - 90
IS - 1-3
M3 - Article
SP - 45
EP - 64
PB - Springer Science & Business Media B.V.
SN - 01676369
AB - Water samples were collected between 1999 and 2000 from wetlands in Minnesota that contained malformed frogs. The water samples were analyzed for 14 minerals/ions and screened for the presence of biologically active compounds using Xenopus laevis. Results indicated that water from two sites, CWB and ROI2, induced severe retardation with embryo lengths reduced 20% after 96 hr of development. The developmental delay observed with water from ROI2 was alleviated by supplementation with sodium, while both sodium and potassium alleviated the developmental delay observed with water whose mineral content mimicked that of CWB. Seasonal fluctuations in the sodium and potassium content at ROI2 and NEY correlated with changes in the rates of Xenopus development. Xenopus embryos reared on water from ROI2 for 120 hr displayed gut malformations not present in embryos reared on a synthetic media designed to mimic the mineral content of the water from ROI2. Embryos reared on water from ROI2 supplemented with minerals at levels comparable to that routinely employed in the rearing of Xenopus were neither retarded nor malformed. It is proposed that climate driven hydrology may influence the mineral composition at selected wetlands and delay development which may alter window(s) of susceptibility towards biologically active agents and the occurrence of malformed frogs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Monitoring & Assessment is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Alkali metals
KW - Aquatic resources
KW - Wetlands
KW - Sodium
KW - High-potassium diet
KW - Low-potassium diet
KW - Minnesota
KW - Frog Embryo Teratogenesis Assay:
KW - frog malformations
KW - potassium
KW - sodium
N1 - Accession Number: 15340720; Garber, Eric A. E. 1; Email Address: GarberE@hotmail.com; Erb, Judith L. 2; Magner, Joseph 3; Larsen, Gerald 1; Affiliations: 1: USDA-ARS, Biosciences Research Laboratory, Fargo, North Dakota, U.S.A. (author for correspondence, address: Division of Natural Products, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, HFS-315, College Park, MD, U.S.A..; 2: ThreeFold Sensors, Ann Arbor, Michigan, U.S.A.; 3: Minnesota Pollution Control Agency, St. Paul, Minnesota, U.S.A.; Issue Info: Jan2004, Vol. 90 Issue 1-3, p45; Thesaurus Term: Alkali metals; Thesaurus Term: Aquatic resources; Thesaurus Term: Wetlands; Thesaurus Term: Sodium; Subject Term: High-potassium diet; Subject Term: Low-potassium diet; Subject: Minnesota; Author-Supplied Keyword: Frog Embryo Teratogenesis Assay:; Author-Supplied Keyword: frog malformations; Author-Supplied Keyword: potassium; Author-Supplied Keyword: sodium; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buzatu, Dan A.
AU - Beger, Richard D.
AU - Wilkes, Jon G.
AU - Lay Jr., Jackson O.
T1 - PREDICTING TOXIC EQUIVALENCE FACTORS FROM 13C NUCLEAR MAGNETIC RESONANCE SPECTRA FOR DIOXINS, FURANS, AND POLYCHLORINATED BIPHENYLS USING LINEAR AND NONLINEAR PATTERN RECOGNITION METHODS.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2004/01//
VL - 23
IS - 1
M3 - Article
SP - 24
EP - 31
SN - 07307268
AB - Two quantitative spectrometric data-activity relationships (QSDAR) models have been developed relating 29 dioxin or dioxin-like molecules to their toxic equivalence factors (TEFs). These models were based on patterns in simulated 13C nuclear magnetic resonance (NMR) data with the patterns defined by comparative spectral analysis (CoSA). Two versions of CoSA multiple linear regression (MLR) models using 7 or 10 spectral bins had, respectively, explained variances (r²) of 0.88 and 0.95, and leaveone- out (LOO) cross-validated variances (q²) of 0.78 and 0.88. A third, artificial neural network model-using a feed forward, back propagating, three-layer neural network-produced an r² of 0.99, a LOO q² of 0.82, and a leave-three-out qsup2; of 0.81. A postulated reason that the results of these QSDAR models are better than traditional quantitative structure-activity relationship (QSAR) models is based on the difference in descriptors rather than on any differences in pattern recognition approach. Results suggest that the 13C NMR spectral data contain molecular quantum mechanical information more reflective of each molecule's biochemical properties than do the calculated electrostatic potentials and molecular alignment assumptions used in developing QSAR models. The QSDAR models provide a rapid, simple way to model the toxicity of dioxin and dioxin-like compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QSAR (Biochemistry)
KW - DIOXINS
KW - FURANS
KW - POLYCHLORINATED biphenyls
KW - TOXICOLOGY
KW - ENVIRONMENTAL toxicology
KW - NUCLEAR magnetic resonance spectroscopy
KW - REGRESSION analysis
KW - Dioxin
KW - Spectroscopic data-activity relationship
N1 - Accession Number: 15999604; Buzatu, Dan A. 1; Email Address: dbuzatu@nctr.fda.gov Beger, Richard D. 1 Wilkes, Jon G. 1 Lay Jr., Jackson O. 1; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Source Info: Jan2004, Vol. 23 Issue 1, p24; Subject Term: QSAR (Biochemistry); Subject Term: DIOXINS; Subject Term: FURANS; Subject Term: POLYCHLORINATED biphenyls; Subject Term: TOXICOLOGY; Subject Term: ENVIRONMENTAL toxicology; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: REGRESSION analysis; Author-Supplied Keyword: Dioxin; Author-Supplied Keyword: Spectroscopic data-activity relationship; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kroes, R.
AU - Renwick, A.G.
AU - Cheeseman, M.
AU - Kleiner, J.
AU - Mangelsdorf, I.
AU - Piersma, A.
AU - Schilter, B.
AU - Schlatter, J.
AU - van Schothorst, F.
AU - Vos, J.G.
AU - Würtzen, G
T1 - Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2004/01//
VL - 42
IS - 1
M3 - Article
SP - 65
SN - 02786915
AB - The threshold of toxicological concern (TTC) is a pragmatic risk assessment tool that is based on the principle of establishing a human exposure threshold value for all chemicals, below which there is a very low probability of an appreciable risk to human health. The concept that there are levels of exposure that do not cause adverse effects is inherent in setting acceptable daily intakes (ADIs) for chemicals with known toxicological profiles. The TTC principle extends this concept by proposing that a de minimis value can be identified for many chemicals, in the absence of a full toxicity database, based on their chemical structures and the known toxicity of chemicals which share similar structural characteristics. The establishment and application of widely accepted TTC values would benefit consumers, industry and regulators. By avoiding unnecessary toxicity testing and safety evaluations when human intakes are below such a threshold, application of the TTC approach would focus limited resources of time, cost, animal use and expertise on the testing and evaluation of substances with the greatest potential to pose risks to human health and thereby contribute to a reduction in the use of animals. An Expert Group of the European branch of the International Life Sciences Institute—ILSI Europe—has examined the TTC principle for its wider applicability in food safety evaluation. The Expert Group examined metabolism and accumulation, structural alerts, endocrine disrupting chemicals and specific endpoints, such as neurotoxicity, teratogenicity, developmental toxicity, allergenicity and immunotoxicity, and determined whether such properties or endpoints had to be taken into consideration specifically in a step-wise approach. The Expert Group concluded that the TTC principle can be applied for low concentrations in food of chemicals that lack toxicity data, provided that there is a sound intake estimate. The use of a decision tree to apply the TTC principle is proposed, and this paper describes the step-wise process in detail. Proteins, heavy metals and polyhalogenated-dibenzodioxins and related compounds were excluded from this approach. When assessing a chemical, a review of prior knowledge and context of use should always precede the use of the TTC decision tree. The initial step is the identification and evaluation of possible genotoxic and/or high potency carcinogens. Following this step, non-genotoxic substances are evaluated in a sequence of steps related to the concerns that would be associated with increasing intakes. For organophosphates a TTC of 18μg per person per day (0.3 μg/kg bw/day) is proposed, and when the compound is not an OP, the TTC values for the Cramer structural classes III, II and I, with their respective TTC levels (e.g. 1800, 540 and 90 μg per person per day; or 30, 9 and 1.5 μg/kg bw /day), would be applied sequentially. All other endpoints or properties were shown to have a distribution of no observed effect levels (NOELs) similar to the distribution of NOELs for general toxicity endpoints in Cramer classes I, II and III. The document was discussed with a wider audience during a workshop held in March 2003 (see list of workshop participants). [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - CHEMICALS
KW - DIET
KW - TOXICITY testing
KW - BIOCHEMISTRY
KW - NEUROTOXICOLOGY
KW - Carcinogenicity
KW - de Minimis Risk
KW - Exposure
KW - Food safety
KW - Neurotoxicity
KW - Risk assessment
KW - Teratogenicity
KW - Threshold of toxicological concern (TTC)
KW - Toxicity
N1 - Accession Number: 11400084; Kroes, R. 1 Renwick, A.G. 2 Cheeseman, M. 3 Kleiner, J. 4; Email Address: publications@ilsieurope.be Mangelsdorf, I. 5 Piersma, A. 6 Schilter, B. 7 Schlatter, J. 8 van Schothorst, F. 5 Vos, J.G. 6 Würtzen, G 9; Affiliation: 1: Utrecht University, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Yalelaan 2, PO Box 80176, NL- 3508 TD Utrecht, The Netherlands 2: University of Southampton, Clinical Pharmacology Group, School of Medicine, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, UK 3: Food and Drug Administration, Food Contact Division, HFS-275, 200 C Street SW, Washington DC 20204, USA 4: ILSI Europe, Avenue E. Mounier 83, Box 6, B-1200 Brussels, Belgium 5: Fraunhofer Institute of Toxicology and Aerosol Research, Department of Chemical Risk Assessment, Nicolai Fuchs Strasse 1, D- 30625 Hannover, Germany 6: National Institute of Public Health and the Environment, Antonie Van Leeuwenhoeklaan 9, PO Box 1, NL-3720 BA Bilthoven, The Netherlands 7: Nestlé Research Centre, Vers-chez-les-Blanc, PO Box 44, CH-1000 Lausanne 26, Switzerland 8: Swiss Federal Office of Public Health, Food Toxicology Section, Stauffacherstrasse 101, CH-8004 Zürich, Switzerland 9: Coca-Cola Nordic and Baltic Division, Strandvejen 60, DK-2900, Hellerup, Denmark; Source Info: Jan2004, Vol. 42 Issue 1, p65; Subject Term: RISK assessment; Subject Term: CHEMICALS; Subject Term: DIET; Subject Term: TOXICITY testing; Subject Term: BIOCHEMISTRY; Subject Term: NEUROTOXICOLOGY; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: de Minimis Risk; Author-Supplied Keyword: Exposure; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Teratogenicity; Author-Supplied Keyword: Threshold of toxicological concern (TTC); Author-Supplied Keyword: Toxicity; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.fct.2003.08.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seo, Kyung Won
AU - Kim, Kyu Bong
AU - Kim, Yun Jung
AU - Choi, Ju Young
AU - Lee, Kyung Tae
AU - Choi, Kwang Sik
T1 - Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2004/01//
VL - 42
IS - 1
M3 - Article
SP - 107
SN - 02786915
AB - Phthalates are widely used as a plasticizer and cause a peroxisome proliferation. Peroxisome proliferators (PPs), such as di-2-ethylhexyl phthalate (DEHP) and clofibrate (CF) are known to have a hepatocarcinogenic potential in rodents. It has been proposed that these PPs may cause hepatocellular cancer by an oxidative damage-mediated mechanism(s). The primary purpose of this study is to find whether there is a difference between the oxidative damage by hepatocarcinogenic PPs (DEHP and CF) and the oxidative damage by weak PPs [di-n-butyl phthalate (DBP) and n-butylbenzyl phthalate (BBP)]. The second purpose is to investigate if phthalates can affect the phase I/phase II enzymes, and if the effect of PPs on metabolizing enzymes correlates with peroxisome proliferation or not. After rats were treated with PPs (DEHP, DBP and BBP; 50, 200, 1000 mg/kg, CF; 100 mg/kg, p.o., for 14 days), the activities of metabolizing enzymes and peroxisomal enzymes were investigated, and the oxidative damage was measured using 8-hydroxydeoxyguanosine (8-OHdG) in the DNA and malonedialdehyde (MDA) in the livers. These four PPs significantly increased the relative liver weights, palmitoyl-CoA oxidation and activity of carnitine acetyltransferase. DEHP was found to be the most potent PP among three phthalates. A dramatic and dose-dependent increase in hepatic MDA levels was observed in CF (100 mg/kg), DEHP (⩾50 mg/kg), DBP and BBP (⩾200 mg/kg) groups. However, the 8-OHdG in hepatic DNA was increased only in DEHP (1000 mg/kg) and CF groups. Activities of cytochrome P4501A1, 1A2, 3A4, UDP-glucuronosyl transferase and glutathione S-transferase were decreased overall by PPs, but there is no correlation between the inhibitory effect on metabolizing enzymes and the peroxisome proliferation. These results indicate that 8-OHdG positively correlates with carcinogenic potential of PPs, but other factors as well as peroxisomal H2O2 could be involved in the generation of 8-OHdG and the carcinogenesis of PPs. The present findings also demonstrate that the effect of PPs on xenobiotic metabolizing enzymes may be independent of the peroxisome proliferation and the oxidative stress. Thus it is possible that the PPs affect the hepatic toxification/detoxification capacity even in humans. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHTHALATE esters
KW - PEROXISOMES
KW - RATS as laboratory animals
KW - ENZYMES
KW - PROTEINS
KW - CATALYSTS
KW - GENES
KW - NUCLEIC acids
KW - PLASTICIZERS
KW - 8-hydroxydeoxyguanosine (8-OHdG)
KW - carnitine acetyltransferase (CAT)
KW - clofibrate (CF)
KW - cyanide-insensitive palmitoyl-CoA oxidation (POX)
KW - cytochrome P4504A1 (CYP4A1)
KW - di-2-ethylhexyl phthalate (DEHP)
KW - di-n-butyl phthalate (DBP)
KW - erythromycin N-demethylase, cytochrome P4503A4 (CYP3A4)
KW - ethoxyresorufin O-dealkylase, cytochrome P4501A1 (CYP1A1)
KW - glutathione S-transferase (GST)
KW - malonedialdehyde (MDA)
KW - methoxyresorufin O-dealkylase, cytochrome P4501A2 (CYP1A2)
KW - n-butylbenzyl phthalate (BBP)
KW - N-nitrosodimethylamine N-demethylase, cytochrome P4502E1 (CYP2E1)
KW - Oxidative stress
KW - Peroxisome proliferation
KW - peroxisome proliferators (PPs)
KW - Phthalate
KW - UDP-glucuronosyl transferase (UDP-GT)
KW - Xenobiotic metabolizing enzyme
N1 - Accession Number: 11400087; Seo, Kyung Won 1; Email Address: kwseo@kfda.go.kr Kim, Kyu Bong 1 Kim, Yun Jung 2 Choi, Ju Young 1 Lee, Kyung Tae 2 Choi, Kwang Sik 1; Affiliation: 1: Toxicology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyunggu, Seoul 122-704, South Korea 2: College of Pharmacy, Kyunghee University, 1 Hoegidong, Dongdaemoongu, Seoul 137-701, South Korea; Source Info: Jan2004, Vol. 42 Issue 1, p107; Subject Term: PHTHALATE esters; Subject Term: PEROXISOMES; Subject Term: RATS as laboratory animals; Subject Term: ENZYMES; Subject Term: PROTEINS; Subject Term: CATALYSTS; Subject Term: GENES; Subject Term: NUCLEIC acids; Subject Term: PLASTICIZERS; Author-Supplied Keyword: 8-hydroxydeoxyguanosine (8-OHdG); Author-Supplied Keyword: carnitine acetyltransferase (CAT); Author-Supplied Keyword: clofibrate (CF); Author-Supplied Keyword: cyanide-insensitive palmitoyl-CoA oxidation (POX); Author-Supplied Keyword: cytochrome P4504A1 (CYP4A1); Author-Supplied Keyword: di-2-ethylhexyl phthalate (DEHP); Author-Supplied Keyword: di-n-butyl phthalate (DBP); Author-Supplied Keyword: erythromycin N-demethylase, cytochrome P4503A4 (CYP3A4); Author-Supplied Keyword: ethoxyresorufin O-dealkylase, cytochrome P4501A1 (CYP1A1); Author-Supplied Keyword: glutathione S-transferase (GST); Author-Supplied Keyword: malonedialdehyde (MDA); Author-Supplied Keyword: methoxyresorufin O-dealkylase, cytochrome P4501A2 (CYP1A2); Author-Supplied Keyword: n-butylbenzyl phthalate (BBP); Author-Supplied Keyword: N-nitrosodimethylamine N-demethylase, cytochrome P4502E1 (CYP2E1); Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Peroxisome proliferation; Author-Supplied Keyword: peroxisome proliferators (PPs); Author-Supplied Keyword: Phthalate; Author-Supplied Keyword: UDP-glucuronosyl transferase (UDP-GT); Author-Supplied Keyword: Xenobiotic metabolizing enzyme; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 424610 Plastics Materials and Basic Forms and Shapes Merchant Wholesalers; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2003.08.010
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2005-01899-003
AN - 2005-01899-003
AU - Noe, Tim
AU - Fleming, Candace
AU - Manson, Spero
ED - Nebelkopf, Ethan
ED - Phillips, Mary
ED - Nebelkopf, Ethan, (Ed)
ED - Phillips, Mary, (Ed)
T1 - Reducing Substance Abuse in American Indian and Alaska Native Communities: The Healthy Nations Initiative.
T2 - Healing and mental health for Native Americans: Speaking in red.
Y1 - 2004///
SP - 19
EP - 31
CY - Walnut Creek, CA, US
PB - AltaMira Press
SN - 0-7591-0606-1
SN - 0-7591-0607-X
AD - Noe, Tim, University of Colorado Health Sciences Center, Division of American Indians and Alaska Native Programs, 4455 E. 12th Ave., Box A011-13, Aurora, CO, US, 80045-0508
N1 - Accession Number: 2005-01899-003. Partial author list: First Author & Affiliation: Noe, Tim; Healthy Nations National Program Office, Center for American Indian and Alaska Native Mental Health Research, Department of Psychiatry, University of Colorado Health Sciences Center, CO, US. Release Date: 20050314. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter; Reprint. ISBN: 0-7591-0606-1, Hardcover; 0-7591-0607-X, Paperback. Language: English. Major Descriptor: Alaska Natives; American Indians; Communities; Drug Abuse Prevention; Drug Rehabilitation. Minor Descriptor: Program Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 13.
AB - This chapter is an abridged version of 'Healthy nations: Reducing substance abuse in American Indian and Alaska Native community,' by Tim Noe, M. Div., Candace Fleming, Ph.D., and Spero Manson, Ph.D., which appeared in (Journal of Psychoactive Drugs, 2003, Vol 35[1], 15-25). (The following abstract of the original article appeared in record [rid]2003-03799-005[/rid].) Since 1993, 14 American Indian and Alaska Native (AIAN) communities have worked diligently to reduce the harm due to substance abuse in their communities. Funded by the Robert Wood Johnson Foundation's Healthy Nations Initiative I, these communities implemented creative strategies that span the continuum from community-wide prevention, early identification and treatment to aftercare. Drawing upon the unique strengths of their own cultural traditions to find solutions to local substance abuse problems, these efforts have identified important and useful lessons for not only other AIAN communities, but also for sponsors of substance abuse programming in Indian country and elsewhere. Described here are successful strategies for developing and sustaining substance abuse programs in AIAN communities and an assessment of their impacts and accomplishments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indian communities
KW - Alaska Native communities
KW - substance abuse programs
KW - strategies
KW - 2004
KW - Alaska Natives
KW - American Indians
KW - Communities
KW - Drug Abuse Prevention
KW - Drug Rehabilitation
KW - Program Evaluation
KW - 2004
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kessler, Larry
AU - Ramsey, Scott D.
AU - Tunis, Sean
AU - Sullivan, Sean D.
T1 - FROM THE FIELD Clinical Use Of Medical Devices In The `Bermuda Triangle'.
JO - Health Affairs
JF - Health Affairs
Y1 - 2004/01//Jan/Feb2004
VL - 23
IS - 1
M3 - Article
SP - 200
EP - 207
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - The pace of medical technological development shows no sign of abating. Analyzing the effect of major federal health agencies on the availability of such technology is critical. This paper describes functions of three government health agencies: the Centers for Medicare and Medicaid Services (CMS), the Food and Drug Administration (FDA), and the National Institutes of Health (NIH). Certain medical technologies fall into gaps between these agencies, which pose challenges in today's era of demand for evidence-based medicine. We suggest new policy and pragmatic strategies that can close the gaps and move decision making relevant to technology forward more rapidly than is now the case. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL sciences
KW - TECHNOLOGICAL innovations
KW - UNITED States
KW - CENTERS for Medicare & Medicaid Services (U.S.)
KW - UNITED States. Food & Drug Administration
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 12017116; Kessler, Larry 1 Ramsey, Scott D. 2 Tunis, Sean 3 Sullivan, Sean D. 4; Affiliation: 1: Director, Office of Science and Technology, U.S. Food and Drug Administration, in Rockville, Maryland. 2: Physician and associate member of the Fred Hutchinson Cancer Research Center in Seattle; Washington. 3: Chief medical officer, Centers for Medicare and Medicaid Services in Baltimore, Maryland. 4: Professor of pharmacy and health services and director, Pharmaceutical Outcomes Research and Policy Program, University of Washington in Seattle.; Source Info: Jan/Feb2004, Vol. 23 Issue 1, p200; Subject Term: MEDICAL sciences; Subject Term: TECHNOLOGICAL innovations; Subject Term: UNITED States; Company/Entity: CENTERS for Medicare & Medicaid Services (U.S.) Company/Entity: UNITED States. Food & Drug Administration Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Document Type: Article
L3 - 10.1377/hlthaff.23.1.200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106729425
T1 - Enhancing occupational safety and health through use of the national skill standards.
AU - Palassis J
AU - Schulte PA
AU - Sweeney MH
AU - Okun AH
Y1 - 2004/01//2004 Jan-Mar
N1 - Accession Number: 106729425. Language: English. Entry Date: 20040430. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Career Planning and Development
KW - Occupational Safety -- Education
KW - Occupational Safety -- Standards
KW - Certification
KW - Job Characteristics
KW - Job Market -- Trends
KW - National Institute for Occupational Safety and Health
KW - United States
SP - 90
EP - 98
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 10
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In a voluntary national effort, U.S. industry, education, labor, and government have initiated the development of standards for job skills and competencies in jobs in 15 economic sectors. The aim of the skill standards is to maintain a globally competitive workforce. Efforts to include occupational safety and health knowledge and skills as core elements in these standards are described. The first skill standards to include occupational safety and health competencies were developed for the manufacturing sector, evaluated by 3,800 workers in 700 companies, and published. National skill standards can stimulate extensive training in occupational safety and health, with resultant application to a larger percentage of workers than ever before.
SN - 1077-3525
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226; jpalassis@cdc.gov
U2 - PMID: 15070031.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vela, Nohora P.
AU - Heitkemper, Douglas T.
T1 - Total Arsenic Determination and Speciation in Infant Food Products by Ion Chromatography-Inductively Coupled Plasma-Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/01//Jan/Feb2004
VL - 87
IS - 1
M3 - Article
SP - 244
EP - 252
SN - 10603271
AB - Provides an update on total arsenic levels along with corresponding speciation information in some commercially available infant food products. Description of the use of a trifluoroacetic acid sample treatment method which was developed for determining arsenic speciation in raw rice for the extraction of arsenic species from infant food products.
KW - ARSENIC
KW - CHEMICAL speciation
KW - ANALYTICAL chemistry
KW - BABY foods
KW - FOOD
KW - ACETIC acid
N1 - Accession Number: 12841924; Vela, Nohora P. 1; Email Address: nohora.vela@fda.hhs.gov Heitkemper, Douglas T. 1; Affiliation: 1: U.S. Food and Drug Administration, Forensic Chemistry Center; Source Info: Jan/Feb2004, Vol. 87 Issue 1, p244; Subject Term: ARSENIC; Subject Term: CHEMICAL speciation; Subject Term: ANALYTICAL chemistry; Subject Term: BABY foods; Subject Term: FOOD; Subject Term: ACETIC acid; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 9p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andrews, Wallace H.
T1 - Food Microbiology, Non-Diary.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/01//Jan/Feb2004
VL - 87
IS - 1
M3 - Article
SP - 296
EP - 302
SN - 10603271
AB - Reports on developments within the AOAC Research Institute. Presentation of collaborative studies on food microbiology; Validation of enrichment procedures and media formulations for use with the TECRA Listeria Visual Immunoassay; AOAC Research Institute Advisory Board's formation of a task force which will determine how to complete the harmonization of the Performance Tested Methods and Official Methods of Analysis.
KW - MICROBIOLOGY
KW - ASSOCIATIONS, institutions, etc.
KW - FOOD
KW - BACTERIAL toxins
KW - MICROORGANISMS
KW - TOXINS
N1 - Accession Number: 12841935; Andrews, Wallace H. 1; Email Address: wallace.andrews@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration; Source Info: Jan/Feb2004, Vol. 87 Issue 1, p296; Subject Term: MICROBIOLOGY; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: FOOD; Subject Term: BACTERIAL toxins; Subject Term: MICROORGANISMS; Subject Term: TOXINS; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Dong, Ren G.
AU - Schopper, Aaron W.
T1 - Analysis of effects of friction on the deformation behavior of soft tissues in unconfined compression tests
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2004/01//
VL - 37
IS - 1
M3 - Article
SP - 147
SN - 00219290
AB - Frictionless specimen/platen contact in unconfined compression tests has traditionally been assumed in determining material properties of soft tissues via an analytical solution. In the present study, the suitability of this assumption was examined using a finite element method. The effect of the specimen/platen friction on the mechanical characteristics of soft tissues in unconfined compression was analyzed based on the published experimental data of three different materials (pigskin, pig brain, and human calcaneal fat). The soft tissues were considered to be nonlinear and viscoelastic; the friction coefficient at the contact interface between the specimens and platens was assumed to vary from 0.0 to 0.5. Our numerical simulations show that the tissue specimens are, due to the specimen/platen friction, not compressed in a uniform stress/strain state, as has been traditionally assumed in analytical analysis. The stress of the specimens obtained with the specimen/platen friction can be greater than those with the frictionless specimen/platen contact by more than 50%, even in well-controlled test conditions. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FRICTION
KW - FINITE element method
KW - VISCOELASTICITY
KW - STRAIN (Physiology)
KW - Finite element model
KW - Friction
KW - Non-linear viscoelastic
KW - Soft tissue
KW - Unconfined compression
N1 - Accession Number: 11605869; Wu, John Z.; Email Address: jwu@cdc.gov Dong, Ren G. 1 Schopper, Aaron W. 1; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Jan2004, Vol. 37 Issue 1, p147; Subject Term: FRICTION; Subject Term: FINITE element method; Subject Term: VISCOELASTICITY; Subject Term: STRAIN (Physiology); Author-Supplied Keyword: Finite element model; Author-Supplied Keyword: Friction; Author-Supplied Keyword: Non-linear viscoelastic; Author-Supplied Keyword: Soft tissue; Author-Supplied Keyword: Unconfined compression; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/S0021-9290(03)00240-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yong-Hak Kim, Satish C.
AU - Heinze, Thomas M.
AU - Seong-Jae Kim, Thomas M.
AU - Cerniglia, Carl E.
T1 - Adsorption and Clay-Catalyzed Degradation of Erythromycin A on Homoionic Clays.
JO - Journal of Environmental Quality
JF - Journal of Environmental Quality
Y1 - 2004/01//Jan/Feb2004
VL - 33
IS - 1
M3 - Article
SP - 257
EP - 264
SN - 00472425
AB - Investigates the adsorption and clay-catalyzed degradation of erythromycin A on homoionic clays. Influence of clay type on the adsorption of erythromycin A; Acidity of clay surfaces; Formation of clay-erythromycin A complexes.
KW - Soil degradation
KW - Clay
KW - Catalysis
KW - Soil absorption & adsorption
KW - Erythromycin
N1 - Accession Number: 12196577; Yong-Hak Kim, Satish C. 1; Heinze, Thomas M. 2; Seong-Jae Kim, Thomas M. 1; Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Admin., Jefferson, AR; 2: Division of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Admin., Jefferson, AR; Issue Info: Jan/Feb2004, Vol. 33 Issue 1, p257; Thesaurus Term: Soil degradation; Thesaurus Term: Clay; Thesaurus Term: Catalysis; Thesaurus Term: Soil absorption & adsorption; Subject Term: Erythromycin; NAICS/Industry Codes: 212324 Kaolin and Ball Clay Mining; NAICS/Industry Codes: 212326 Shale, clay and refractory mineral mining and quarrying; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cates, Sheryl C.
AU - Carter-Young, Heather L.
AU - Puro, Edward L.
AU - Post, Robert C.
AU - Manka, Anita
T1 - Consumer Attitudes Toward and Preferences for Food Standards of Identity.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2004/01//
VL - 10
IS - 1
M3 - Article
SP - 67
EP - 84
SN - 10454446
AB - Federal food standards of identity protect consumers from nutritional and economic fraud by establishing standardized names and characteristics for some products. Standards have been criticized for a variety of reasons, raising the possibility that standards may be harmful to the consumers' interests that they are designed to protect. The authors conducted focus groups to collect information on consumers' attitudes toward food standards and their perceived usefulness. Many participants believed that standards are useful and deemed standards to be more important for some types of products than others. Regulators can use the study findings to guide policy decisions on food standards. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Products Marketing is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMERS -- Attitudes
KW - FOOD industry
KW - STANDARDS
KW - CONSUMER behavior
KW - CONSUMER protection
KW - PRODUCT safety
KW - UNITED States
N1 - Accession Number: 13530470; Cates, Sheryl C. 1; Email Address: scc@rti.org Carter-Young, Heather L. 1 Puro, Edward L. 2 Post, Robert C. 3 Manka, Anita 3; Affiliation: 1: Research Policy Analyst, and Heather L. Carter-Young is Policy Analyst 2: Economist, Center for Food Safety and Applied Nutrition, Food and Drug Administration, U.S. Department of Health and Human Services. 3: Director, Labeling and Consumer Protection Staff, and Anita Manka is Senior Analyst, Office of International Affairs; Source Info: 2004, Vol. 10 Issue 1, p67; Subject Term: CONSUMERS -- Attitudes; Subject Term: FOOD industry; Subject Term: STANDARDS; Subject Term: CONSUMER behavior; Subject Term: CONSUMER protection; Subject Term: PRODUCT safety; Subject Term: UNITED States; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1300/j038v10n01_04
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Edelson-Mammel, Sharon G.
AU - Buchanan, Robert L.
T1 - Thermal Inactivation of Enterobacter sakazakii in Rehydrated Infant Formula.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/01//
VL - 67
IS - 1
M3 - Article
SP - 60
EP - 63
SN - 0362028X
AB - The presence of low levels of Enterobacter sakazakii in dried infant formula have been linked to outbreaks of meningitis, septicemia, and necrotizing enterocolitis in neonates, particularly those who are premature or immunocompromised. In the current study, the ability of 12 strains of E. sakazakii to survive heating in rehydrated infant formula was determined at 58°C with a submerged coil apparatus. The observed D[sub 58]-values ranged from 30.5 to 591.9 s, with the strains appearing to fall into two distinct heat resistance phenotypes. The z-value of the most heat-resistant strain was 5.6°C. When dried infant formula containing this strain was rehydrated with water preequilibrated to various temperatures, a more than 4-log reduction in E. sakazakii levels was achieved by preparing the formula with water at 70°C or greater. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Heat
KW - Temperature
KW - Water
KW - Infant formulas
KW - Enterobacter
KW - Neonatal necrotizing enterocolitis
N1 - Accession Number: 12272010; Edelson-Mammel, Sharon G. 1; Buchanan, Robert L. 1; Email Address: robert.buchanan@cfsan.fda.gov; Affiliations: 1: Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, Maryland, USA; Issue Info: Jan2004, Vol. 67 Issue 1, p60; Thesaurus Term: Heat; Thesaurus Term: Temperature; Thesaurus Term: Water; Subject Term: Infant formulas; Subject Term: Enterobacter; Subject Term: Neonatal necrotizing enterocolitis; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 4p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Benner Jr., R.A.
AU - Staruszkiewicz, W.F.
AU - Otwell, W.S.
T1 - Putrescine, Cadaverine, and Indole Production by Bacteria Isolated from Wild and Aquacultured Penaeid Shrimp Stored at 0, 12, 24, and 36°C.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/01//
VL - 67
IS - 1
M3 - Article
SP - 124
EP - 133
SN - 0362028X
AB - Putrescine, cadaverine, and indole production capabilities of bacteria isolated from wild domestic and aquacultured Nicaraguan penaeid shrimp in progressive decomposition states were evaluated. The numbers and types of microorganisms responsible for the production of putrescine, cadaverine, and indole in wild and aquacultured shrimp increased with increasing decomposition temperature and time. Throughout the storage experiments, mean aerobic plate counts (log/g) ranged from 4.5 to 9.7 and 4.5 to 9.0 for domestic and Nicaraguan shrimp, respectively. Vibrio spp. were more prominent in Nicaraguan shrimp (Litopenaeus vannamei) than in domestic shrimp (Litopenaeus setiferus and Litopenaeus brasiliensis). The only amine-producing (putrescine) microorganism isolated from wild and aquacultured shrimp at all temperatures of decomposition (0, 12, 24, and 36°C) was Shewanella putrefaciens. On the basis of putrescine production by S. putrefaciens at 0 and 12°C and putrescine production by S. putrefaciens, Vibrio spp., and Morganella morganii at 24 and 36°C, putrescine should be considered a potential chemical indicator of decomposition in shrimp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Penaeidae
KW - Bacteria
KW - Aquaculture
KW - Temperature
KW - Putrescine
KW - Nicaragua
N1 - Accession Number: 12272020; Benner Jr., R.A. 1; Email Address: rbenner@cfsan.fda.gov; Staruszkiewicz, W.F. 2; Otwell, W.S. 1; Affiliations: 1: Aquatic Food Products Laboratory, Food Science and Human Nutrition Department, University of Florida; 2: U.S. Food and Drug Administration, Office of Seafood, Washington Seafood Laboratory, Maryland, USA; Issue Info: Jan2004, Vol. 67 Issue 1, p124; Thesaurus Term: Penaeidae; Thesaurus Term: Bacteria; Thesaurus Term: Aquaculture; Thesaurus Term: Temperature; Subject Term: Putrescine; Subject: Nicaragua; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Staruszkiewicz, Walter F.
AU - Barnett, James D.
AU - Rogers, Patricia L.
AU - Benner Jr., Ronald A.
AU - Wong, Lynn L.
AU - Cook, John
T1 - Effects of On-Board and Dockside Handling on the Formation of Biogenic Amines in Mahimahi (Coryphaena hippurus), Skipjack Tuna (Katsuwonus pelamis), and Yellowfin Tuna (Thunnus albacares).
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/01//
VL - 67
IS - 1
M3 - Article
SP - 134
EP - 141
SN - 0362028X
AB - Consumer illnesses by scombroid poisonings have been a continuing problem for many years. The intoxications follow the ingestion of fish such as tuna and mahimahi that have undergone bacterial decomposition, leading to the formation of biogenic amines. Research studies have concluded that histamine is one of the indicators of scombrotoxic fish and that other amines, such as cadaverine, could be involved in the illnesses. Guidance for the handling of fish on board fishing vessels to prevent the production of scombrotoxic fish has been limited by a lack of data addressing changes that occur in fish from the water to delivery at dockside. In this study, the changes in selected biogenic amines were determined in mahimahi and tuna, which were captured and held in seawater at 25 to 35°C for incubation times up to 18 h. The fillets from the treated fish were sectioned by transverse cuts and analyzed for histamine, cadaverine, and putrescine. Results showed that at 26°C, more than 12 h of incubation were required before a histamine concentration of 50 ppm was reached in mahimahi. At 35°C, 50 ppm histamine formed within 9 h. Similar results were found for skipjack and yellowfin tuna. Histamine concentrations exceeded 500 ppm within an additional 3 h of incubation in mahimahi. At both temperatures, an increase in the concentration of cadaverine preceded an increase in histamine levels. Changes in putrescine concentrations in the fish were less pronounced. The study also demonstrated that histidine decarboxylase activity was retained in some frozen samples of fish and could result in further increases in histamine on thawing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food poisoning
KW - Food handling
KW - Dolphinfishes
KW - Biogenic amines
KW - Skipjack tuna
KW - Yellowfin tuna
N1 - Accession Number: 12272021; Staruszkiewicz, Walter F. 1; Email Address: wstarusz@cfsan.fda.gov; Barnett, James D. 2; Rogers, Patricia L. 1; Benner Jr., Ronald A. 1; Wong, Lynn L. 3; Cook, John 3; Affiliations: 1: U.S. Food and Drug Administration, Washington Seafood Laboratory, Maryland; 2: U.S. Food and Drug Administration, Seattle Regional Laboratory, Washington; 3: U.S. Food and Drug Administration, Honolulu Residence Post, Hawaii, USA; Issue Info: Jan2004, Vol. 67 Issue 1, p134; Thesaurus Term: Food poisoning; Thesaurus Term: Food handling; Thesaurus Term: Dolphinfishes; Subject Term: Biogenic amines; Subject Term: Skipjack tuna; Subject Term: Yellowfin tuna; NAICS/Industry Codes: 114111 Finfish Fishing; Number of Pages: 8p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Penteado, Ana Lucia
AU - Eblen, B. Shawn
AU - Miller, Arthur J.
T1 - Evidence of Salmonella Internalization into Fresh Mangos during Simulated Postharvest Insect Disinfestation Procedures.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/01//
VL - 67
IS - 1
M3 - Article
SP - 181
EP - 184
SN - 0362028X
AB - A recent U.S. salmonellosis outbreak was epidemiologically associated with consumption of imported fresh mangos. Studies were conducted to simulate the commercial heat disinfestation method used to eliminate tephritid fly larvae from mangos, as well as subsequent product cooling procedures, to assess whether this process promotes internalization of Salmonella into mangos. The experimental parameters were chosen to mimic the disinfestation method used by the South American producer/packer implicated in the recent outbreak. Untreated domestically grown immature and ripened Tommy Atkins variety mangos were immersed in water at 47°C for 90 min and then immersed in 21°C water containing brilliant blue FD&C no. 1 dye for 10 min. After dye internalization potential was established (67%), the same experiment was performed using 21°C water containing 10[sup 7] CFU/ml Salmonella Enteritidis expressing constitutive green fluorescent protein. Fruit was then stored at 10, 20, or 30°C for up to 1 week. Immature and ripened mangos were positive for Salmonella internalization at a frequency of 80 and 87%, respectively. Internalization frequency into the stem-end segment (83%) was significantly higher (P < 0.05) than internalization into the middle-side (19%) or blossom-end (9%) segments of the fruit. Salmonella was detected in the mango pulp after 1 week of incubation. The degree of fruit ripeness, posttreatment holding temperature, or duration of storage had no significant effect (P > 0.05) on internalization frequency or survival of Salmonella inside mangos. This study illustrates the high potential for pathogen internalization if heat-disinfested mangos are cooled using contaminated water. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Mango
KW - Tephritidae
KW - Heating
KW - Harvesting
KW - Water
N1 - Accession Number: 12272029; Penteado, Ana Lucia 1; Eblen, B. Shawn 2; Miller, Arthur J. 2; Email Address: amiller@cfsan.fda.gov; Affiliations: 1: Departamento de Tecnologia de Alimentos, Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas, Cidade Universitária, "Zeferino Vaz," Brazil; 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Maryland, USA; Issue Info: Jan2004, Vol. 67 Issue 1, p181; Thesaurus Term: Salmonella; Thesaurus Term: Mango; Thesaurus Term: Tephritidae; Thesaurus Term: Heating; Thesaurus Term: Harvesting; Thesaurus Term: Water; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ferreira, J.L.
AU - Eliasberg, S.J.
AU - Edmonds, P.
AU - Harrison, M.A.
T1 - Comparison of the Mouse Bioassay and Enzyme-Linked Immunosorbent Assay Procedures for the Detection of Type A Botulinal Toxin in Food.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/01//
VL - 67
IS - 1
M3 - Article
SP - 203
EP - 206
SN - 0362028X
AB - Samples of chili linked to a foodborne illness outbreak of type A botulism were examined for preformed type A botulinal toxin using two enzyme-linked immunosorbent assay (ELISA) procedures and the mouse bioassay. One of the samples was positive for type A botulinal toxin and three of the samples were negative for type A, B, E, and F botulinal toxins using the three methods. The mouse bioassay indicated that type A toxin was present at the 10,000 minimal lethal dose per gram (MLD per g) of product. The ELISA tests indicated a toxicity of 7,650 MLD per g with one method and 8,350 MLD per g with the other method. The sample toxicity determined by the ELISA was estimated by comparing samples to a standard curve generated with standard type A neurotoxin in casein buffer. The ELISA methods are more rapid than the mouse bioassay, since the toxin type can be determined in 1 day. The mouse bioassay is more sensitive than the ELISA but usually requires multiple assays to obtain the toxin type and toxicity. Type A culture isolates from the sample were also verified using one ELISA method. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Botulism
KW - Food poisoning
KW - Foodborne diseases
KW - Biological assay
KW - Neurotoxic agents
KW - Enzyme-linked immunosorbent assay
N1 - Accession Number: 12272034; Ferreira, J.L. 1; Email Address: jferreir@ora.fda.gov; Eliasberg, S.J. 1; Edmonds, P. 2; Harrison, M.A. 3; Affiliations: 1: U.S. Food and Drug Administration, Georgia; 2: School of Biology, Georgia Institute of Technology; 3: Department of Food Science and Technology, University of Georgia; Issue Info: Jan2004, Vol. 67 Issue 1, p203; Thesaurus Term: Botulism; Thesaurus Term: Food poisoning; Thesaurus Term: Foodborne diseases; Thesaurus Term: Biological assay; Thesaurus Term: Neurotoxic agents; Subject Term: Enzyme-linked immunosorbent assay; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - LEE, Y. C.
AU - KIM, I. H.
AU - CHANG, J.
AU - RHEE, Y. K.
AU - OH, H. I.
AU - PARK, H. K.
T1 - Chemical Composition and Oxidative Stability of Safflower Oil Prepared with Expeller from Safflower Seeds Roasted at Different Temperatures.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2004/01//
VL - 69
IS - 1
M3 - Article
SP - FCT33
EP - FCT38
SN - 00221147
AB - BSTRACT: Seeds with different roasting (140°C to 180°C) and expelling (110°C to 150°C) temperatures were evaluated. The color development of their oils increased as both temperatures increased. The fatty acid compositions did not change, the major one being linoleic acid (80%). There were significant differences in the phosphorus content of oils prepared at different roasting temperatures, which was not the case with oils prepared at different expelling temperatures. The major phospholipid component of oil is phosphatidylinositol. The proportion of phosphatidylinositol in oil increased as both temperatures increased. Phosphatidylethanolamine in oil decreased as roasting temperatures increased. Tocopherols and tocotrienols were identified. The oxidative stabilities increased as both temperatures increased. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAFFLOWER oil
KW - ROASTING (Cooking)
KW - LINOLEIC acid
KW - PHOSPHORUS
KW - FOOD -- Fatty acid content
N1 - Accession Number: 63160070; LEE, Y. C. 1; Email Address: yclee@kfri.re.kr KIM, I. H. 1; Email Address: yclee@kfri.re.kr CHANG, J. 1; Email Address: yclee@kfri.re.kr RHEE, Y. K. 1; Email Address: yclee@kfri.re.kr OH, H. I. 1; Email Address: yclee@kfri.re.kr PARK, H. K. 1; Email Address: yclee@kfri.re.kr; Affiliation: 1: Authors Lee, Chang, and Rhee are with korea Food Research Institute, San 46-1, Baekhyun-Dong, Bundang-Ku, Songnam City, Kyonggi-Do, 463-746, Republic of Korea. Author Kim is with the Dept. of Food and Nutrition, College of Health Sciences, Korea Univ., Chungneung-Dong, Sungbuk-Ku, Republic of Korea. Author Oh is with the Dept. of Food Science and Technology, Sejong Univ., Republic of Korea. Author Park is with the Food Evaluation Dept., Korea Food and Drug Administration, Nokbun-Dong, Eunpyong-Ku, Seoul, Korea. Direct inquiries to author Lee (E-mail: ).; Source Info: Jan2004, Vol. 69 Issue 1, pFCT33; Subject Term: SAFFLOWER oil; Subject Term: ROASTING (Cooking); Subject Term: LINOLEIC acid; Subject Term: PHOSPHORUS; Subject Term: FOOD -- Fatty acid content; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1365-2621.2004.tb17852.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luebke, Robert W.
AU - Parks, Christine
AU - Luster, Michael I.
T1 - Suppression of Immune Function and Susceptibility to Infections in Humans: Association of Immune Function with Clinical Disease.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2004/01//
VL - 1
IS - 1
M3 - Article
SP - 15
EP - 24
PB - Taylor & Francis Ltd
SN - 1547691X
AB - A number of regulatory agencies in western Europe, Japan and the United States now include guidelines for evaluating the potential immunotoxicity of chemicals, including drugs, as part of routine toxicity testing. Most testing guidelines recommend observational or functional assays that, based on studies in laboratory animals, are able to detect changes in immune function that are associated with increased susceptibility to infectious or neoplastic cell challenge. To appreciate how well observational and functional endpoints are likely to predict an increased risk of infection in humans, it is important to establish correlations between alterations in human immune function and an increased risk of disease. This review will address the clinical evidence for increased risk of disease in humans with mild to moderate levels of immunosuppression using examples from the literature, discuss specific immune system defects associated with increased rates of infection, and examine factors that impact the interpretation of clinical data. The most comprehensive data bases that address these relationships, those derived from patients with primary immunodeficiency and AIDS, are not discussed in this review. These are extreme examples of immunodeficiency and neither the specific clinical diseases that result, nor eventual outcomes, have much in common with that which occurs in individual with chronic mild-to-moderate immunosuppression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Infection
KW - AIDS (Disease)
KW - Immunotoxicology
KW - Drugs
KW - Clinical drug trials
KW - Immune system
KW - Diseases -- Risk factors
KW - Immunosuppression
KW - Immunologic diseases
N1 - Accession Number: 15314095; Luebke, Robert W. 1; Email Address: luebke.robert@epa.gov; Parks, Christine 2; Luster, Michael I. 3; Affiliations: 1: Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 2: Epidemiology Branch, Environmental Diseases & Medicine Program, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA; 3: Toxicology & Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: Jan2004, Vol. 1 Issue 1, p15; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Infection; Thesaurus Term: AIDS (Disease); Subject Term: Immunotoxicology; Subject Term: Drugs; Subject Term: Clinical drug trials; Subject Term: Immune system; Subject Term: Diseases -- Risk factors; Subject Term: Immunosuppression; Subject Term: Immunologic diseases; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/15476910490438342
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tarkowski, Trudee A.
AU - Koumans, Emilia H.
AU - Sawyer, Mary
AU - Pierce, Antonya
AU - Black, Carolyn M.
AU - Papp, John R.
AU - Markowitz, Lauri
AU - Unger, Elizabeth R.
T1 - Epidemiology of Human Papillomavirus Infection and Abnormal Cytologic Test Results in an Urban Adolescent Population.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/01//1/1/2004
VL - 189
IS - 1
M3 - Article
SP - 46
EP - 50
SN - 00221899
AB - Studies the prevalence of and the risk factors for human papillomavirus (HPV) infection and abnormal cytologic test results in adolescent girls. Detection of cervical HPV; Independent risk factors for HPV; Cytologic abnormalities.
KW - DISEASES
KW - Communicable diseases
KW - Papillomaviruses
KW - Cytology
KW - Teenage girls
KW - Cervix uteri
KW - Sexually transmitted diseases
N1 - Accession Number: 11974306; Tarkowski, Trudee A. 1; Koumans, Emilia H. 2; Sawyer, Mary; Pierce, Antonya 2; Black, Carolyn M. 1; Papp, John R. 1; Markowitz, Lauri 2; Unger, Elizabeth R. 1; Affiliations: 1: National Center for Infectious Diseases; 2: National Center for HIV, STD, and TV Prevention, Centers for Disease Control and Prevention, Public Health Service ,U.S. Department of Health and Human Services; Issue Info: 1/1/2004, Vol. 189 Issue 1, p46; Thesaurus Term: DISEASES; Thesaurus Term: Communicable diseases; Subject Term: Papillomaviruses; Subject Term: Cytology; Subject Term: Teenage girls; Subject Term: Cervix uteri; Subject Term: Sexually transmitted diseases; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106600566
T1 - Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population.
AU - Tarkowski TA
AU - Koumans EH
AU - Sawyer M
AU - Pierce A
AU - Black CM
AU - Papp JR
AU - Markowitz L
AU - Unger ER
AU - Tarkowski, Trudee A
AU - Koumans, Emilia H
AU - Sawyer, Mary
AU - Pierce, Antonya
AU - Black, Carolyn M
AU - Papp, John R
AU - Markowitz, Lauri
AU - Unger, Elizabeth R
Y1 - 2004/01//1/1/2004
N1 - Accession Number: 106600566. Language: English. Entry Date: 20050401. Revision Date: 20161128. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Centers for Disease Control and Prevention. NLM UID: 0413675.
KW - Adolescent Health
KW - Cervix Diseases -- Epidemiology
KW - Papillomavirus Infections -- Epidemiology -- In Adolescence
KW - Cervical Smears
KW - Papillomavirus Infections -- Risk Factors
KW - Urban Areas
KW - Prevalence
KW - Cross Sectional Studies
KW - Univariate Statistics
KW - Multivariate Analysis
KW - Chi Square Test
KW - Odds Ratio
KW - Data Analysis Software
KW - Confidence Intervals
KW - Adolescence
KW - Female
KW - Funding Source
KW - Human
SP - 46
EP - 50
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 189
IS - 1
PB - Oxford University Press / USA
AB - We determined the prevalence of and the risk factors for human papillomavirus (HPV) infection and abnormal cytologic test results in 312 adolescent girls (mean age, 16.1 years). Subjects had a median of 2 years of sexual activity and 4 lifetime sex partners. Cervical HPV was detected by use of L1-consensus polymerase chain reaction in 64% of subjects; half of those with HPV had >1 type, and 77% had >/=1 high-risk type. Independent risk factors for HPV were lifetime number of sex partners, age of partner, and douching. Cytologic abnormalities were common (20.9% of subjects had atypical squamous cells of uncertain significance, and 17.0% had high- or low-grade squamous intraepithelial lesions) and were significantly associated with detection of HPV (P=.0001); however, most (51.6%) subjects with HPV had normal cytologic test results.
SN - 0022-1899
AD - National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA
AD - National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services
U2 - PMID: 14702152.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - The management of the diabetic Charcot foot in Native Americans living in a rural setting: a series of case studies. (Abstract)
AU - McPoil, T.
AU - Cornwall, M.
AU - Manrique, K.
JO - Journal of Orthopaedic & Sports Physical Therapy
JF - Journal of Orthopaedic & Sports Physical Therapy
Y1 - 2004/01//
VL - 34
IS - 1
SP - A25
EP - a26
CY - ;
SN - 01906011
N1 - Accession Number: SPHS-937077; Author: McPoil, T.: 1 Author: Cornwall, M.: 2 Author: Manrique, K.: 3 ; Author Affiliation: 1 Physical Therapy, Northern Arizona University, Flagstaff AZ: 2 Physical Therapy, Northern Arizona University, Flagstaff AZ: 3 Physical Therapy, Tuba City Indian Health Service Hospital, Tuba City, AZ; No. of Pages: 2; Language: English; Parent Item: SPHP1980; General Notes: Orthopaedic section research abstracts: poster presentations.; Publication Type: Article; Material Type: PRINT; Update Code: 20060501; SIRC Article No.: S-937077
KW - *DISEASES
KW - *DIABETES
KW - *DIABETIC foot
KW - *THERAPEUTICS
KW - *NEUROPATHY
KW - INDIANS of North America
KW - CASE studies
KW - PROGRAMS
KW - ADULTHOOD
KW - WOMEN
KW - MALES
L2 - http://articles.sirc.ca/search.cfm?id=S-937077
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UR - http://articles.sirc.ca/search.cfm?id=S-937077
UR - http://www.apta.org/
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Lague
AU - P.
AU - Pastor
AU - R. W.
AU - Brooks
AU - B. R.
T1 - Pressure-Based Long-Range Correction for Lennard-Jones Interactions in Molecular Dynamics Simulations: Application to Alkanes and Interfaces.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2004/01//
VL - 108
IS - 1
M3 - Article
SP - 363
EP - 368
SN - 15206106
AB - A straightforward method that accounts for the long-range Lennard-Jones (LJ) terms in constant pressure molecular dynamics simulations is presented. This long-range correction (LRC) consists of an additional applied pressure tensor which is periodically calculated from the difference of instantaneous pressures at the selected cutoff and a very long cutoff. It provides results that are nearly independent of the LJ cutoff distance at negligible additional calculation costs, and is particularly suited for anisotropic systems such as liquid/liquid interfaces or heterogeneous macromolecules where approximations based on spherically symmetric radial distribution functions are expected to fail. The utility of the method is demonstrated for a series of alkanes and water, and for interfaces including a lipid bilayer. The LRC increases densities and decreases isothermal compressibilities, with the changes larger for alkanes than for water (where the long-range interactions are dominated by electrostatic interactions). While implementation of the LRC will not necessarily improve agreement with a particular experiment, it will provide a baseline for improvements in a parameter set that are consistent with the long-range Lennard-Jones interactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR dynamics
KW - SIMULATION methods & models
KW - TENSOR algebra
KW - MACROMOLECULES
N1 - Accession Number: 11845861; Lague P. 1 Pastor R. W. 1 Brooks B. R. 1; Affiliation: 1: Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, Maryland 20852-1448; Source Info: Jan2004, Vol. 108 Issue 1, p363; Subject Term: MOLECULAR dynamics; Subject Term: SIMULATION methods & models; Subject Term: TENSOR algebra; Subject Term: MACROMOLECULES; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Monheit, Alan C.
AU - Steinberg Schone, Barbara
AD - U Medicine and Dentistry of NJ
AD - US Agency for Healthcare Research and Quality, Rockville
T1 - How Has Small Group Market Reform Affected Employee Health Insurance Coverage?
JO - Journal of Public Economics
JF - Journal of Public Economics
Y1 - 2004/01//
VL - 88
IS - 1-2
SP - 237
EP - 254
SN - 00472727
N1 - Accession Number: 0674302; Keywords: Health Insurance; Health; Insurance; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200402
N2 - In the early 1990s, over 40 states passed legislation designed to limit a number of exclusionary practices by insurers in the small group market in order to improve the availability and affordability of health insurance to employees in small firms. In this paper, we address the effects of reform on the likelihood that workers are offered insurance, have employment-based coverage, or are policyholders of an employment-based plan. We use differences-in-differences (DD) and differences-in-differences-in-differences (DDD) estimators to evaluate the differential effects of alternative reform measures on high and low risk workers. We generally find little effect of reform on offer rates and find that, in states with the most stringent reform, employment-based coverage and policyholder rates increased for high risk workers relative to low risk workers. Our results also indicate that the effects of reform varied significantly by the extent to which states adopted guaranteed issue.
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://www.sciencedirect.com/science/journal/00472727
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UR - http://dx.doi.org/10.1016/S0047-2727(02)00133-0
UR - http://www.sciencedirect.com/science/journal/00472727
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Weara, Keith A.
T1 - Measurement of dependence of backscatter coefficient from cylinders on frequency and diameter using focused transducers— with applications in trabecular bone.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2004/01//
VL - 115
IS - 1
M3 - Article
SP - 66
EP - 72
SN - 00014966
AB - A theory for the elastic scattering response from a cylinder insonified by a plane wave was previously derived by Faran. In the present paper, the empirical relationship between Faran's theory and measurements of backscatter coefficient from cylindrical targets using focused transducers is investigated. Experimental measurements of dependence of backscatter coefficient on frequency and diameter for nylon wires are reported. It is found that, under certain conditions (including weak, incoherent scattering), backscatter coefficient measurements from collections of cylindrical scatterers may be meaningfully compared with Faran's model predictions. At low frequencies, the theory and experimental measurements exhibit similar dependences on frequency and diameter, provided that the scatterers are not too densely packed. At higher frequencies, the fine structure of Faran's predictions becomes difficult to reproduce experimentally with a focused transducer. Implications regarding applications to characterization of trabecular bone are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACOUSTIC impedance
KW - AUDIO frequency
KW - TRANSDUCERS
KW - ELECTRONIC apparatus & appliances
KW - ACOUSTICAL engineering
N1 - Accession Number: 20589690; Weara, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142, 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Jan2004, Vol. 115 Issue 1, p66; Subject Term: ACOUSTIC impedance; Subject Term: AUDIO frequency; Subject Term: TRANSDUCERS; Subject Term: ELECTRONIC apparatus & appliances; Subject Term: ACOUSTICAL engineering; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 811211 Consumer Electronics Repair and Maintenance; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; Number of Pages: 7p; Illustrations: 1 Chart, 11 Graphs; Document Type: Article
L3 - 10.1121/1.1631943
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murphy, William J.
AU - Franks, John R.
AU - Berger, Elliott H.
AU - Behar, Alberto
AU - Casali, John G.
AU - Dixon-Ernst, Christine
AU - Krieg, Edward F.
AU - Mozo, Ben T.
AU - Royster, Julia D.
AU - Royster, Larry H.
AU - Simon, Stephen D.
AU - Stephenson, Carol
T1 - Development of a new standard laboratory protocol for estimation of the field attenuation of hearing protection devices: Sample size necessary to provide acceptable reproducibility.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2004/01//
VL - 115
IS - 1
M3 - Article
SP - 311
EP - 323
SN - 00014966
AB - The mandate of ASA Working Group S12/WG11 has been to develop ''laboratory and/or field procedure(s) that yield useful estimates of field performance'' of hearing protection devices (HPDs). A real-ear attenuation at threshold procedure was selected, devised, tested for one earmuff and three earplugs via an interlaboratory study involving five laboratories and 147 subjects, and incorporated into a new standard that was approved in 1997 [Royster et al., ''Development of a new standard laboratory protocol for estimating the field attenuation of hearing protection devices. Part I. Research of Working Group 11, Accredited Standards Committee S12, Noise,'' J. Acoust. Soc. Am. 99, 1506-1526; ANSI, S12.6-1997, ''American National Standard method for measuring real-ear attenuation of hearing protectors'' (American National Standards Institute, New York, 1997)]. The subject-fit methodology of ANSI S12.6-1997 relies upon listeners who are audiometrically proficient, but inexperienced in the use of HPDs. Whenever a new method is adopted, it is important to know the effects of variability on the power of the measurements. In evaluation of protector noise reduction determined by experimenter-fit, informed-user-fit, and subject-fit methods, interlaboratory reproducibility was found to be best for the subject-fit method. Formulas were derived for determining the minimum detectable difference between attenuation measurements and for determining the number of subjects necessary to achieve a selected level of precision. For a precision of 6 dB, the study found that the minimum number of subjects was 4 for the Bilsom UF-1 earmuff, 10 for the E.A.R Classic earplug, 31 for the Willson EP100 earplug, and 22 for the PlasMed V-51R earplug. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEARING
KW - NOISE control -- Equipment & supplies
KW - ATTENUATION (Physics)
KW - ACOUSTICAL engineering
KW - SOUND
N1 - Accession Number: 20589718; Murphy, William J. 1; Email Address: wmurphy@cdc.gov Franks, John R. 1 Berger, Elliott H. 2 Behar, Alberto 3 Casali, John G. 4 Dixon-Ernst, Christine 5 Krieg, Edward F. 6 Mozo, Ben T. 7 Royster, Julia D. 8 Royster, Larry H. 8 Simon, Stephen D. 9 Stephenson, Carol 10; Affiliation: 1: Hearing Loss Prevention Section, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS C-27, Cincinnati, Ohio 45226 2: E.A.R/Aearo Company, 7911 Zionsville Road, Indianapolis, Indiana 46268-1657 3: University of Toronto, 45 Meadowcliffe Drive, Scarborough, Ontario M1M2X8, Canada 4: Virginia Tech, 250 Durham Hall, Blacksburg, Virginia 24061 5: Alcoa Corporate Center, 201 Isabella Street, Pittsburgh, Pennsylvania 15212-5828 6: Monitoring Research & Statistics Activity, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS C-22, Cincinnati, Ohio 45226 7: Communications & Ear Protection Inc., 303 South Ouida Street, Enterprise, Alabama, 36331 8: Environmental Noise Consultants, P.O. Box 30698, Raleigh, North Carolina 27622-0698 9: Office of Medical Research, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, Missouri 64108 10: Training and Education Systems Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS C-10, Cincinnati, Ohio 45226; Source Info: Jan2004, Vol. 115 Issue 1, p311; Subject Term: HEARING; Subject Term: NOISE control -- Equipment & supplies; Subject Term: ATTENUATION (Physics); Subject Term: ACOUSTICAL engineering; Subject Term: SOUND; Number of Pages: 13p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1121/1.1633559
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106766301
T1 - Addressing the challenges to improve long-term care.
AU - Correa-de-Araujo R
Y1 - 2004/01//Jan/Feb2004
N1 - Accession Number: 106766301. Language: English. Entry Date: 20040813. Revision Date: 20150711. Publication Type: Journal Article; editorial; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100893243.
KW - Drug Therapy -- Standards
KW - Gerontologic Care
KW - Long Term Care
KW - Nursing Homes
KW - Quality Improvement
SP - 57
EP - 58
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
JA - J AM MED DIR ASSOC
VL - 5
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1525-8610
AD - Agency for Healthcare Research and Quality, Dept of Health and Human Services, Rockville, MD
U2 - PMID: 14706131.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106766301&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106764051
T1 - Herbal supplement use among US women, 2000.
AU - Yu SM
AU - Ghandour RM
AU - Huang ZJ
Y1 - 2004///Winter2004
N1 - Accession Number: 106764051. Language: English. Entry Date: 20040806. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503064.
KW - Dietary Supplementation -- Utilization
KW - Health Behavior -- United States
KW - Women's Health
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Blacks
KW - Chi Square Test
KW - Confidence Intervals
KW - Data Analysis Software
KW - Demography
KW - Drug Therapy, Combination
KW - Echinacea -- Therapeutic Use
KW - Epidemiological Research
KW - Ethnic Groups
KW - Female
KW - Ginkgo Biloba -- Therapeutic Use
KW - Ginseng -- Therapeutic Use
KW - Health Status
KW - Hispanics
KW - Middle Age
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - Secondary Analysis
KW - Self Medication
KW - Socioeconomic Factors
KW - St. John's Wort -- Therapeutic Use
KW - Surveys
KW - United States
KW - Whites
KW - Human
SP - 17
EP - 24
JO - Journal of the American Medical Women's Association
JF - Journal of the American Medical Women's Association
JA - J AM MED WOMENS ASSOC
VL - 59
IS - 1
CY - Reston, Virginia
PB - American Medical Women's Association
AB - ObjectiveTo examine the prevalence of herbal supplement use and its association with sociodemographic, health status, and health behavior characteristics in a nationally representative sample of US women.MethodsWe analyzed the cancer supplement file of the 2000 National Health Interview Survey, which included 11 888 non-Hispanic white, 2866 non-Hispanic black, 3035 Hispanic, and 599 non-Hispanic other women. Bivariate and multivariate analyses were conducted to examine the relationship between sociodemographic, health status, and health behavior characteristics and the use of: 1) any herbal supplement; 2) Echinacea, Ginkgo biloba, ginseng, or St. John's wort, and 3) at least 3 herbal supplements concurrently.ResultsNearly one-sixth of US women took at least 1 herbal supplement in 2000. Logistic regression showed that women who were non-Hispanic white, aged 35 to 64 years, more educated, not poor, current alcohol users, residents of the South and West, and who had functional limitations and chronic conditions were significantly more likely to take the most commonly reported herbal supplements.ConclusionOur study suggests high levels of herbal supplement use among US women. Supplement use is generally associated with higher education, higher income, residence in the South and West, and health needs. The growing practice of herbal supplement use suggests a need for public health guidance on the safe and efficacious use of these products.
SN - 0098-8421
AD - Epidemiologist, Office of Data and Information Management, Maternal and Child Health Bureau
U2 - PMID: 14768981.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Li Huang Wang, Kenji
AU - Xiao Yi Yang, Kenji
AU - Xiaohu Zhang
AU - Mihalic, Kelly
AU - Ying-Xin Fan
AU - Weihua Xia, Kelly
AU - O. M. Zack Howard, Kelly
AU - Ettore Appella, Kelly
AU - Maynard, Andrew T.
AU - Farrar, William L.
T1 - Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2004/01//
VL - 10
IS - 1
M3 - Article
SP - 40
EP - 47
PB - Nature Publishing Group
SN - 10788956
AB - Current antiestrogen therapy for breast cancer is limited by the mixed estrogenic and antiestrogenic activity of selective estrogen receptor modulators. Here we show that the function of zinc fingers in the estrogen receptor DNA-binding domain (DBD) is susceptible to chemical inhibition by electrophilic disulfide benzamide and benzisothiazolone derivatives, which selectively block binding of the estrogen receptor to its responsive element and subsequent transcription. These compounds also significantly inhibit estrogen-stimulated cell proliferation, markedly reduce tumor mass in nude mice bearing human MCF-7 breast cancer xenografts, and interfere with cell-cycle and apoptosis regulatory gene expression. Functional assays and computational analysis support a molecular mechanism whereby electrophilic agents preferentially disrupt the vulnerable C-terminal zinc finger, thus suppressing estrogen receptor-mediated breast carcinoma progression. Our results provide the proof of principle for a new strategy to inhibit breast cancer at the level of DNA binding, rather than the classical antagonism of estrogen binding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - ESTROGEN -- Therapeutic use
KW - GENES
KW - CELL proliferation
KW - ZINC-finger proteins
KW - SELECTIVE estrogen receptor modulators
N1 - Accession Number: 11817955; Li Huang Wang, Kenji 1 Xiao Yi Yang, Kenji 1 Xiaohu Zhang 1 Mihalic, Kelly 1 Ying-Xin Fan 2 Weihua Xia, Kelly 1 O. M. Zack Howard, Kelly 3 Ettore Appella, Kelly 1 Maynard, Andrew T. 1 Farrar, William L. 4; Email Address: farrar@ncifcrf.gov; Affiliation: 1: National Cancer Institute-Frederick, National Institutes of Health, PO Box B, Frederick, Maryland 21702, USA 2: Division of Therapeutic Protein, Center for Biological Evaluation and Research, Food and Drug Administration, 40 Convent Drive, Bethesda, Maryland 20892, USA 3: Laboratory of Cell Biology, National Cancer Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA 4: Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick, national Institutes of Health, PO Box B, Frederick Maryland 21702, USA; Source Info: Jan2004, Vol. 10 Issue 1, p40; Subject Term: BREAST cancer; Subject Term: ESTROGEN -- Therapeutic use; Subject Term: GENES; Subject Term: CELL proliferation; Subject Term: ZINC-finger proteins; Subject Term: SELECTIVE estrogen receptor modulators; Number of Pages: 8p; Document Type: Article
L3 - 10.1038/nm969
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kodell, Ralph L.
AU - Turturro, Angelo
T1 - RISK-ASSESSMENT IMPLICATIONS OF MECHANISTIC MODEL'S PREDICTION OF LOW-DOSE NONLINEARITY OF LIVER TUMOR RISK FOR MICE FED FUMONISIN B1.
JO - Nonlinearity in Biology, Toxicology & Medicine
JF - Nonlinearity in Biology, Toxicology & Medicine
Y1 - 2004/01//Jan-Mar2004
VL - 2
IS - 1
M3 - Article
SP - 35
EP - 43
SN - 15401421
AB - A two-stage, clonal-expansion model of liver tumor risk in mice was developed by Kodell et al. (Food Addit Contam 18:23 7-253; 2001) based on the hypothesis that fumonisin B1, a naturally occurring mycotoxin in corn, is not genotoxic, but rather causes cancer through the disruption of sphingolipid metabolism. This disruption is assumed to cause an increase in apoptosis, in response to which cells proliferate to compensate for reduced tissue mass. The resulting differential increase in the number of pre-neoplastic cells at risk of mutation during cell division is assumed to lead to an increase in the incidence of tumors. Two-year liver tumor incidences predicted by the model using data on organ weight, cell proliferation, and sphingolipid metabolism provided a reasonable match to the actual 2-year observed incidences in a study conducted at the National Center for Toxicological Research. The predictions indicated no risk at low doses (even a possible hormetic effect) and high risk at high doses in females, as well as a complete absence of a dose response (or perhaps, a hormetic effect) in males. This paper provides a commentary on the risk-assessment implications of the modeling results, pointing out that the model's low-dose predictions provide scientific support and justification for the US. Food and Drug Administration is low-ppm guidance levels in corn products. These guidance levels are significantly higher than would be obtained using linear extrapolation, the method most often used for genotoxic carcinogens and other carcinogens for which low-dose linearity cannot be ruled out. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nonlinearity in Biology, Toxicology & Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Carcinogenicity
KW - Toxicology
KW - Liver tumors
KW - Fumonisins
KW - Hormesis
KW - apoptosis
KW - FDA guidance
KW - hormesis
KW - mycotoxin
KW - nongenotoxic
N1 - Accession Number: 14037679; Kodell, Ralph L. 1; Email Address: rkodell@nctr.fda.gov; Turturro, Angelo 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; Issue Info: Jan-Mar2004, Vol. 2 Issue 1, p35; Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogenicity; Thesaurus Term: Toxicology; Subject Term: Liver tumors; Subject Term: Fumonisins; Subject Term: Hormesis; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: FDA guidance; Author-Supplied Keyword: hormesis; Author-Supplied Keyword: mycotoxin; Author-Supplied Keyword: nongenotoxic; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15401420490426981
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106757684
T1 - Gene and bacterial identification using high-throughput technologies: genomics, proteomics, and phonemics.
AU - Al-Khaldi SF
AU - Mossoba MM
Y1 - 2004/01//
N1 - Accession Number: 106757684. Language: English. Entry Date: 20040723. Revision Date: 20150820. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8802712.
KW - Bacteria -- Analysis
KW - Bacteriological Techniques
KW - Genetic Techniques
KW - Proteins -- Analysis
KW - Biochips
KW - Funding Source
KW - Genes
KW - Spectrum Analysis
SP - 32
EP - 38
JO - Nutrition
JF - Nutrition
JA - NUTRITION
VL - 20
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0899-9007
AD - Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland, MD 20740-3855; sufian.al-khaldi@cfsan.fda.gov
U2 - PMID: 14698011.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Steenland, K.
AU - Stayner, L.
AU - Deddens, J.
T1 - Mortality analyses in a cohort of 18 235 ethylene oxide exposed workers: follow up extended from 1987 to 1998.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2004/01//
VL - 61
IS - 1
M3 - Article
SP - 2
EP - 7
SN - 13510711
AB - Aims: To extend mortality follow up from 1987 to 1998 for cohort of 18 235 men and women exposed to ethylene oxide. Methods: Standard mortality follow up, life table and Cox regression analysis. Results: There were 2852 deaths, compared with 1177 in the earlier 1987 follow up. There was no overall excess of haematopoietic cancers combined or of non-Hodgkin's lymphoma. However, internal exposure-response analyses found positive trends for haematopoietic cancers which were limited to males (15 year lag). The trend in haematopoietic cancer was driven by lymphoid tumours (non-Hodgkin's lymphoma, myeloma, lymphocytic leukaemia), which also have a positive trend with cumulative exposure for males with a 15 year lag. Haematopoietic cancer trends were somewhat weaker in this analysis than trends in the earlier follow up, and analyses restricted to the post-1987 data did not show any significant positive trends (exposure levels dropped sharply in the early 1980s). Breast cancer did not show any overall excess, although there was an excess in the highest cumulative exposure quartile using a 20 year lag. Internal exposure-response analyses found positive trend for breast cancer using the log of cumulative exposure with a 20 year lag. Conclusions: There was little evidence of any excess cancer mortality for the cohort as a whole, with the exception of bone cancer based on small numbers. Positive exposure-response trends for lymphoid tumours were found for males only. Reasons for the sex specificity of this effect are not known. There was also some evidence of a positive exposure-response for breast cancer mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mortality
KW - Ethylene oxide
KW - Cancer
KW - Death
KW - Lymphomas
KW - Hodgkin's disease
N1 - Accession Number: 12292174; Steenland, K. 1; Email Address: nsteenl@sph.emory.edu; Stayner, L. 2; Deddens, J. 2; Affiliations: 1: Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 2: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA; Issue Info: Jan2004, Vol. 61 Issue 1, p2; Subject Term: Mortality; Subject Term: Ethylene oxide; Subject Term: Cancer; Subject Term: Death; Subject Term: Lymphomas; Subject Term: Hodgkin's disease; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 6p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pinkerton, L. E.
AU - Hein, M. J.
AU - Ward, E. M.
AU - Bloom, T. F.
T1 - Mortality among a cohort of uranium mill workers: an update.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2004/01//
VL - 61
IS - 1
M3 - Article
SP - 57
EP - 64
SN - 13510711
AB - Aims: To evaluate the mortality experience of 1484 men employed in seven uranium mills in the Colorado Plateau for at least one year on or after 1 January 1940. Methods: Vital status was updated through 1998, and life table analyses were conducted. Results: Mortality from all causes and all cancers was less than expected based on US mortality rates. A statistically significant increase in non-malignant respiratory disease mortality and non-significant increases in mortality from lymphatic and haematopoietic malignancies other than leukaemia, lung cancer, and chronic renal disease were observed. The excess in lymphatic and haematopoietic cancer mortality was due to an increase in mortality from lymphosarcoma and reticulosarcoma and Hodgkin's disease. Within the category of non-malignant respiratory disease, mortality from emphysema and pneumoconioses and other respiratory disease was increased. Mortality from lung cancer and emphysema was higher among workers hired prior to 1955 when exposures to uranium, silica, and vanadium were presumably higher. Mortality from these causes of death did not increase with employment duration. Conclusions: Although the observed excesses were consistent with our a priori hypotheses, positive trends with employment duration were not observed. Limitations included the small cohort size and limited power to detect a moderately increased risk for some outcomes of interest, the inability to estimate individual exposures, and the lack of smoking data. Because of these limitations, firm conclusions about the relation of the observed excesses in mortality and mill exposures are not possible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Uranium
KW - Mortality
KW - Hematopoietic system
KW - Colorado Plateau
KW - United States
N1 - Accession Number: 12292184; Pinkerton, L. E. 1; Email Address: LPinkerton@cdc.gov; Hein, M. J. 1; Ward, E. M. 1; Bloom, T. F. 1; Affiliations: 1: The National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA; Issue Info: Jan2004, Vol. 61 Issue 1, p57; Thesaurus Term: Uranium; Subject Term: Mortality; Subject Term: Hematopoietic system; Subject: Colorado Plateau; Subject: United States; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106772930
T1 - Mortality among a cohort of uranium mill workers: an update.
AU - Pinkerton LE
AU - Bloom TF
AU - Hein MJ
AU - Ward EM
Y1 - 2004/01//
N1 - Accession Number: 106772930. Language: English. Entry Date: 20040903. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Funded in part by the United States Army Center for Health Promotion and Preventive Medicine and the United States Department of Energy. NLM UID: 9422759.
KW - Extraction and Processing Industry
KW - Mining
KW - Occupational Diseases -- Mortality
KW - Uranium
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Cause of Death
KW - Colorado
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Male
KW - Middle Age
KW - Neoplasms -- Etiology
KW - Neoplasms -- Mortality
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Analysis
KW - Prospective Studies
KW - Respiratory Tract Diseases -- Etiology
KW - Respiratory Tract Diseases -- Mortality
KW - Funding Source
KW - Human
SP - 57
EP - 64
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 61
IS - 1
PB - BMJ Publishing Group
AB - AIMS: To evaluate the mortality experience of 1484 men employed in seven uranium mills in the Colorado Plateau for at least one year on or after 1 January 1940. METHODS: Vital status was updated through 1998, and life table analyses were conducted. RESULTS: Mortality from all causes and all cancers was less than expected based on US mortality rates. A statistically significant increase in non-malignant respiratory disease mortality and non-significant increases in mortality from lymphatic and haematopoietic malignancies other than leukaemia, lung cancer, and chronic renal disease were observed. The excess in lymphatic and haematopoietic cancer mortality was due to an increase in mortality from lymphosarcoma and reticulosarcoma and Hodgkin's disease. Within the category of non-malignant respiratory disease, mortality from emphysema and pneumoconioses and other respiratory disease was increased. Mortality from lung cancer and emphysema was higher among workers hired prior to 1955 when exposures to uranium, silica, and vanadium were presumably higher. Mortality from these causes of death did not increase with employment duration. CONCLUSIONS: Although the observed excesses were consistent with our a priori hypotheses, positive trends with employment duration were not observed. Limitations included the small cohort size and limited power to detect a moderately increased risk for some outcomes of interest, the inability to estimate individual exposures, and the lack of smoking data. Because of these limitations, firm conclusions about the relation of the observed excesses in mortality and mill exposures are not possible.
SN - 1351-0711
AD - Epidemiology Section, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226; LPinkerton@cdc.gov
U2 - PMID: 14691274.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106737970
T1 - Spotlight on research: assessing the performance of surgical gloves.
AU - Baker K
A2 - Krouse HJ
Y1 - 2004///2004 Winter
N1 - Accession Number: 106737970. Language: English. Entry Date: 20040528. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Korniewicz DM, El-Masri MM, Broyles JM, Martin CD, O'Connell KP. A laboratory-based study to assess the performance of surgical gloves. (AORN J) Apr2003; 77 (4): 772-779. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9206573.
KW - Gloves -- Evaluation
KW - Latex
KW - Comparative Studies
KW - Powders
KW - Product Evaluation
KW - Simulations
SP - 34
EP - 35
JO - ORL-Head & Neck Nursing
JF - ORL-Head & Neck Nursing
JA - ORL HEAD NECK NURS
VL - 22
IS - 1
CY - New Smyrna Beach, Florida
PB - Society of Otorhinolaryngology & Head-Neck Nurses
SN - 1064-3842
AD - Nurse Consultant, Ear, Nose and Throat Devices Branch, Office of Device Evaluation, Center for Devices and Radiological Health, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Muhuri, Pradip K.
AU - MacDorman, Marian F.
AU - Ezzati-Rice, Trena M.
T1 - Racial differences in leading causes of infant death in the United States.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2004/01//
VL - 18
IS - 1
M3 - Article
SP - 51
EP - 60
PB - Wiley-Blackwell
SN - 02695022
AB - We used linked birth/infant death records of over 23 million singletons belonging to six birth cohorts (1989–91 and 1995–97) and examined changes in race differentials in the overall and cause-specific infant mortality risks across time in the United States. Results show that infant mortality declined for all races during the time period, with disproportionately greater declines among non-Hispanic American Indians (AIs). Among the leading causes of infant death, declines in mortality from sudden infant death syndrome (SIDS), respiratory distress syndrome (RDS) and congenital anomalies contributed the most to the overall decline in infant mortality in the 1995–97 cohorts, compared with the 1989–91 cohorts. Disproportionately greater reductions in mortality resulting from SIDS and congenital anomalies led to more rapid mortality declines among non-Hispanic AIs than for other races. There are disturbing findings that infants of almost every race experienced increases in mortality from newborn affected by maternal complications of pregnancy (maternal complications) and that none of the race groups experienced a significant decline in mortality from disorders resulting from short gestation/low birthweight. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY & race
KW - HISPANIC Americans
KW - PRODUCTIVE life span
KW - ETHNIC groups
KW - ETHNOLOGY
KW - UNITED States
N1 - Accession Number: 12010937; Muhuri, Pradip K. 1; Email Address: pmuhuri@cdc.gov MacDorman, Marian F. 2 Ezzati-Rice, Trena M. 3; Affiliation: 1: Office of Research and Methodology, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville 2: Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville 3: Centre for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Jan2004, Vol. 18 Issue 1, p51; Subject Term: MORTALITY & race; Subject Term: HISPANIC Americans; Subject Term: PRODUCTIVE life span; Subject Term: ETHNIC groups; Subject Term: ETHNOLOGY; Subject Term: UNITED States; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1365-3016.2004.00535.x
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Lutter, Randall
AU - Shogren, Jason F.
AD - US Food and Drug Administration
AD - U WY
A2 - Lutter, Randall
A2 - Shogren, Jason F.
T1 - Painting the White House Green Green: Rationalizing Environmental Policy Inside the Executive Office of the President: Lessons from a Hot Seat
T2 - Painting the White House green: Rationalizing environmental policy inside the executive office of the president
PB - Washington, D.C.:
PB - Resources for the Future
Y1 - 2004///
SP - 1
EP - 9
N1 - Accession Number: 0825404; Reviewed Book ISBN: 1-891853-73-2 (cloth); 1-891853-72-4 (pbk); ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200603
KW - Political Processes: Rent-seeking, Lobbying, Elections, Legislatures, and Voting Behavior D72
KW - Climate; Natural Disasters; Global Warming Q54
KW - Environmental Economics: Government Policy Q58
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Lutter, Randall
AD - US Food and Drug Administration
A2 - Lutter, Randall
A2 - Shogren, Jason F.
T1 - Head in the Clouds Decision-Making: EPA's Air Quality Standards for Ozone
T2 - Painting the White House green: Rationalizing environmental policy inside the executive office of the president
PB - Washington, D.C.:
PB - Resources for the Future
Y1 - 2004///
SP - 46
EP - 66
N1 - Accession Number: 0825406; Reviewed Book ISBN: 1-891853-73-2 (cloth); 1-891853-72-4 (pbk); Keywords: Air Quality; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200603
KW - Political Processes: Rent-seeking, Lobbying, Elections, Legislatures, and Voting Behavior D72
KW - Air Pollution; Water Pollution; Noise; Hazardous Waste; Solid Waste; Recycling Q53
KW - Climate; Natural Disasters; Global Warming Q54
KW - Environmental Economics: Government Policy Q58
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Gibson, Tammie J.
AU - Nash, David A.
T1 - Practice Patterns of Board-certified Pediatric Dentists: Frequency and Method of Cleaning Children's Teeth.
JO - Pediatric Dentistry
JF - Pediatric Dentistry
Y1 - 2004/01//Jan/Feb2004
VL - 26
IS - 1
M3 - Article
SP - 17
EP - 22
SN - 01641263
AB - Purpose: The purpose of this study was to assess the periodicity of the recall examination and frequency and most often used technique for cleaning children's teeth. The resulting data were compared to current scientific evidence and recommendations to determine the appropriateness of practices by board-certified pediatric dentists. Methods: A 28-item questionnaire was mailed to the 1,034 members of the College of Diplomates of the American Board of Pediatric Dentistry residing in the United States. This report describes data pertaining to recall appointment periodicity, frequency and method of cleaning children's teeth, use of auxiliaries in prophylaxis, and instruction in oral hygiene. Results: Six hundred twenty-nine surveys were returned, tabulated, and analyzed. Only 1% of dentists did not have an active recall program, 95% used a 6-month recall interval, and the remaining 5% had an interval ranging from 3 to 18 months. Hygienists were employed in 62% of pediatric dentistry practices. Pumice/rubber cup prophylaxis was employed routinely at recall by 67% of respondents; 24% reported the use of tooth-brush and dental floss for cleaning; the other 9% reported no routine method for prophylaxis. The average fee for a pumice/rubber cup prophylaxis was $42.55, and $40.31 for a toothbrush prophylaxis. One hundred percent of pediatric dentists reported providing oral hygiene instruction for their patients. The instruction was directed to both parent and child in 97% of practices, child only in 2% of practices, and the parent only in 1% of practices. Conclusions: Recall intervals were not based on specific criteria related to individual patient needs. The majority of pediatric dentists employed the pumice/rubber cup prophylaxis method for cleaning children's teeth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Dentistry is the property of American Society of Dentistry for Children and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRIC dentistry
KW - CHILDREN -- Dental care
KW - TEETH -- Care & hygiene
KW - PREVENTIVE dentistry
KW - DENTAL prophylaxis
KW - DENTAL hygiene
KW - PEDIATRIC DENTISTRY.
KW - PREVENTION
KW - PUMICE
KW - RECALL APPOINTMENTS
KW - RUBBER CUP PROPHYLAXIS
KW - TOOTHBRUSH PROPHYLAXIS
N1 - Accession Number: 13083917; Gibson, Tammie J. 1 Nash, David A. 2; Affiliation: 1: Pediatric dentist, US Public Health Service, Lawton Indian Hospital, Lawton, OKla. 2: Professor of dental education and professor of pediatric dentistry and bioethics, University of Kentucky Medical Center, Lexington, Ky.; Source Info: Jan/Feb2004, Vol. 26 Issue 1, p17; Subject Term: PEDIATRIC dentistry; Subject Term: CHILDREN -- Dental care; Subject Term: TEETH -- Care & hygiene; Subject Term: PREVENTIVE dentistry; Subject Term: DENTAL prophylaxis; Subject Term: DENTAL hygiene; Author-Supplied Keyword: PEDIATRIC DENTISTRY.; Author-Supplied Keyword: PREVENTION; Author-Supplied Keyword: PUMICE; Author-Supplied Keyword: RECALL APPOINTMENTS; Author-Supplied Keyword: RUBBER CUP PROPHYLAXIS; Author-Supplied Keyword: TOOTHBRUSH PROPHYLAXIS; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106657271
T1 - Health status and health services utilization among US Chinese, Asian Indian, Filipino, and other Asian/Pacific Islander children.
AU - Yu SM
AU - Huang ZJ
AU - Singh GK
Y1 - 2004/01//
N1 - Accession Number: 106657271. Language: English. Entry Date: 20050507. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Asians -- In Infancy and Childhood -- United States
KW - Chinese -- In Infancy and Childhood -- United States
KW - Filipinos -- In Infancy and Childhood -- United States
KW - Health Resource Utilization -- In Infancy and Childhood
KW - Health Status -- In Infancy and Childhood
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Infant
KW - Interviews
KW - Logistic Regression
KW - Odds Ratio
KW - Random Sample
KW - Secondary Analysis
KW - United States
KW - Human
SP - 101
EP - 107
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
IS - 1
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: This study examines the health status and health services access and utilization characteristics of US Chinese, Asian Indian, Filipino, other Asian/Pacific Islander (API), and non-Hispanic white children by using nationally representative data. METHODS: We analyzed the aggregated data file from the National Health Interview Survey from 1997 to 2000 including 334 Chinese, 287 Asian Indian, 292 Filipino, 696 'other API,' and 29,016 non-Hispanic white children <18 years old. Bivariate and multivariate analyses were conducted to examine the relationship between Asian ethnicities and dependent variables including components of health status, health services access, and utilization. RESULTS: Logistic regression reveals that all Asian American children were less likely to miss school because of illness or injury or have learning disabilities compared with non-Hispanic whites. Other APIs were less likely to be taking prescription medication for at least 3 months, and Asian Indian children were half as likely to have chronic conditions. Chinese, Filipino, and other API children were more likely to be without contact with a health professional within the past 12 months. Citizenship/nativity status, maternal education attainment, and poverty status were all significant independent risk factors for health care access and utilization. CONCLUSIONS: Asian ethnicities and being foreign-born are generally associated with more favorable health status measures such as school absence, learning disability, use of prescription medications, and chronic conditions. However, these attributes are negatively associated with health care access and utilization, suggesting the need for outreach to Asian immigrant populations to educate them on accessing the US health care system.
SN - 0031-4005
AD - Maternal and Child Health Bureau, 5600 Fishers Ln, 18A-55, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 14702456.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
AU - Fuchs, Victor R.
AU - McClellan, Mark
AU - Skinner, Jonathan
AD - Stanford U
AD - US Food and Drug Administration and Stanford U
AD - Dartmouth College
A2 - Wise, David A.
T1 - Area Differences in Utilization of Medical Care and Mortality among U.S. Elderly
T2 - Perspectives on the economics of aging
PB - NBER Conference Report series.
PB - Chicago and London:
PB - University of Chicago Press
Y1 - 2004///
SP - 367
EP - 406
N1 - Accession Number: 0792881; Reviewed Book ISBN: 0-226-90305-2; Keywords: Elderly; Medical Care; Mortality; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200509
KW - Analysis of Health Care Markets I11
KW - Health Production I12
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Bharati Manda
AU - Carol R. Drinkard
AU - Deborah Shatin
AU - David J. Graham
T1 - The risk of esophageal obstruction associated with an anti-allergy medication (Claritin-D® 24-Houroriginal formulation) (The findings and conclusions of this study are those of the authors and do not necessarily reflect the views of the Food and Drug Administration.) Findings of this study were presented at the Annual Meeting of the Academy for Health Services Research and Policy, June 2001, Atlanta.)
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2004/01//
VL - 13
IS - 1
M3 - Article
SP - 29
EP - 34
SN - 10538569
AB - To investigate a possible increased risk of esophageal obstruction among users of loratadine and pseudoephedrine (Claritin-D® 24-Hour C-D 24, the original, round, extended-release formulation) compared to two other tablet formulations of loratadine. Pharmacy data of 12 managed care plans were screened to identify users in the three groups from 1 September 1996 to 31 December 1998. Users with a medical claim following their first loratadine prescription (Index prescription) indicating an esophageal obstruction or endoscopic procedure were considered claims-identified cases. Medical records were reviewed to validate case status. There were 233 901 users (61% female) and 245 claims-identified cases occurring within 30 days after the first prescription. The incidence rate per 10 000 users of claims-identified cases occurring on the Index prescription date was higher among C-D 24 users (IR = 1.4) than Claritin® Regular (C-R) users (IR = 0.07; p < 0.002) or Claritin-D® 12-Hour (C-D 12) users (IR = 0.3; p > 0.05). Medical record review of 15 claims-identified cases confirmed two cases of acute esophageal obstruction, both among C-D 24 users. Claims-based analysis suggested an increased risk of endoscopic procedures on the Index date among C-D 24 users compared to C-R users. However, after medical record review, the study did not provide conclusive evidence of an association between C-D 24 use and esophageal obstruction. This study highlights the importance of validating findings from claims data using medical records. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Esophagus
KW - Ephedrine
KW - Dosage forms of drugs
KW - Managed care plans (Medical care)
KW - Prescription of drugs
N1 - Accession Number: 12112830; Bharati Manda 1; Carol R. Drinkard 1; Deborah Shatin 1; David J. Graham 2; Affiliations: 1: Center for Health Care Policy and Evaluation, United Health Group, Minneapolis, MN, USA; 2: Office of Drug Safety, US Food and Drug Administration, Rockville, MD, USA; Issue Info: Jan2004, Vol. 13 Issue 1, p29; Thesaurus Term: DISEASES; Subject Term: Esophagus; Subject Term: Ephedrine; Subject Term: Dosage forms of drugs; Subject Term: Managed care plans (Medical care); Subject Term: Prescription of drugs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baitang Ning
AU - Charles Wang
AU - Fabrice Morel
AU - Susan Nowell
AU - D L Ratnasinghe
AU - Waleetka Carter
AU - Fred F Kadlubar
AU - Brian Coles
T1 - Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form.
JO - Pharmacogenetics
JF - Pharmacogenetics
Y1 - 2004/01//
VL - 14
IS - 1
M3 - Article
SP - 35
EP - 44
SN - 0960314X
AB - Variability of expression of the major glutathione S-transferases (GSTs) of liver, GSTA1 and GSTA2, is thought to affect the efficiency of detoxification of xenobiotics, including chemical carcinogens. Polymorphism of the GSTA1 regulatory sequence determines some of the variation of hepatic GSTA1 expression, but the polymorphisms in GSTA2 (exons 5 and 7) were not thought to affect GSTA2 activity. By examining GST protein expression for a set of human liver and pancreas samples (coupled with a cloning/polymerase chain reaction-restriction fragment length polymorphism strategy), we identified a novel substitution ProSer (328C>T) and the corresponding novel variant GSTA2*E (SerSerLysGlu), and confirmed the presence of variants GSTA2*A (ProSerLysGlu), GSTA2*B (ProSerLysAla) and GSTA2*C (ProThrLysGlu). GSTA2*C occurred at 3060% (i.e. approximately 100-fold more frequent than previously reported) and GSTA2*E occurred (heterozygous) at approximately 11%. Hepatic expression of the Ser variants (GSTA2*A, GSTA2*B or GSTA2*E) was approximately four-fold higher than that of the Thr variant (GSTA2*C). Compared to any other variant, GSTA2E had lower rates of catalysis towards 1-chloro-2,4-dinitrobenzene (CDNB), 4-vinylpyridine, and cumene-, t-butyl- and arachidonic acid hydroperoxides, although kcat/Km for CDNB were similar for all four variants. Using a prostate cancer casecontrol population, it was found that GSTA1*A/GSTA2 C335 and GSTA1*B/GSTA2 G335 were in linkage disequilibrium in Caucasians but not in AfricanAmericans. However, there were no significant differences in the distribution of these polymorphisms or resultant haplotypes by case status. Nevertheless, the rare genotypes, GSTA2*E/*E and GSTA1*B/*B + GSTA2*C/*C (potential low GSTA2 activity and low hepatic GSTA1 and GSTA2 expression, respectively) could increase the risk of adverse effects of xenobiotics via compromised efficiency of detoxification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenetics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE cancer
KW - CATALYSIS
KW - EXOCRINE glands
KW - CANCER
N1 - Accession Number: 18424179; Baitang Ning 1 Charles Wang Fabrice Morel Susan Nowell D L Ratnasinghe Waleetka Carter Fred F Kadlubar Brian Coles; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA and INSERM U456, Universit de Rennes 1, Rennes, France.; Source Info: Jan2004, Vol. 14 Issue 1, p35; Subject Term: PROSTATE cancer; Subject Term: CATALYSIS; Subject Term: EXOCRINE glands; Subject Term: CANCER; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lucca, Anna M.
AU - Henry, Alexis D.
AU - Banks, Steven
AU - Simon, Lorna
AU - Page, Stephanie
T1 - EVALUATION OF AN INDIVIDUAL PLACEMENT AND SUPPORT MODEL (IPS) PROGRAM.
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
Y1 - 2004///Winter2004
VL - 27
IS - 3
M3 - Article
SP - 251
EP - 257
SN - 1095158X
AB - While randomized clinical trials (RCTs) have helped to establish Individual Placement and Support (IPS) programs as an evidence-based practice, it is important to evaluate whether ‘real world’ IPS programs can be implemented with fidelity and achieve outcomes comparable to programs evaluated in RCTs. The current evaluation examined retrospectively employment outcomes for 90 participants from an IPS-model Services for Employment and Education (SEE) program in Massachusetts over a 4.5-year period. Evaluators accessed demographic, functioning, and employment data from three sources—SEE program records/database, clinical records, and the Massachusetts Department of Mental Health Client Tracking system. Results indicate that the SEE program maintained high IP5 fidelity and achieved employment outcomes comparable or superior to other SE and IP5 model programs described in the literature. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychiatric Rehabilitation Journal is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - CLINICAL medicine -- Research
KW - HEALTH promotion
KW - MEDICAL care
KW - EMPLOYMENT (Economic theory)
KW - JOB creation
KW - MASSACHUSETTS
KW - UNITED States
N1 - Accession Number: 12184006; Lucca, Anna M. 1; Email Address: anna.lucca@lewin.com Henry, Alexis D. 2,3 Banks, Steven 4 Simon, Lorna 5 Page, Stephanie 6; Affiliation: 1: Clinical Psychologist, The Lewin Group, Washington, DC 2: Assistant Professor, Department of Rehabilitation Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University 3: Research Assistant, Professor of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA 4: Associate Professor of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School 5: Research Associate, Center for Mental Health Services Research, University of Massachusetts Medical School 6: Associate Financial Planner, Metropolitan Life Financial Services, Wethersfield, CT; Source Info: Winter2004, Vol. 27 Issue 3, p251; Subject Term: CLINICAL trials; Subject Term: CLINICAL medicine -- Research; Subject Term: HEALTH promotion; Subject Term: MEDICAL care; Subject Term: EMPLOYMENT (Economic theory); Subject Term: JOB creation; Subject Term: MASSACHUSETTS; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahn, Hyun-Joo
AU - Lee, Cherl-Ho
AU - Kim, Jae-Hyun
AU - Han, Sang-Bae
AU - Jo, Cheorun
AU - Kim, Sung
AU - Byun, Myung-Woo
T1 - Identification of radiolytic products from N-nitrosodimethylamine and N-nitrosopyrrolidine by gas chromatography and mass spectrometry
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/01//
VL - 69
IS - 1
M3 - Article
SP - 99
SN - 0969806X
AB - The radiolytic products of N-nitrosodimethylamine (NDMA) and N-nitrosopyrrolidine (NPYR) dissolved in dichloromethane (DCM) were identified after gamma irradiation. The UV spectra of NDMA and NPYR indicated that irradiation reduced the typical peak of NDMA at 258 nm and NPYR at 260 nm.The major radiolytic components identified in irradiated NDMA were ethyl acetate and 2-dimethyl propanol. The irradiated NPYR dissolved in DCM and produced 2-butanone and 2-methyl-6-propyl piperidine as the major radiolytic components. 2-Methyl-6-propyl piperidine was the component detected in the greatest concentration in irradiated NPYR. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION chemistry
KW - DIMETHYLNITROSAMINE
KW - DICHLOROMETHANE
KW - ULTRAVIOLET spectra
KW - Gamma irradiation
KW - N-Nitrosodimethylamine
KW - N-Nitrosopyrrolidine
KW - Radiolysis
N1 - Accession Number: 11465052; Ahn, Hyun-Joo 1 Lee, Cherl-Ho 2 Kim, Jae-Hyun 1 Han, Sang-Bae 3 Jo, Cheorun 1 Kim, Sung 4 Byun, Myung-Woo 1; Email Address: mybyun@kaeri.re.kr; Affiliation: 1: Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, PO. Box 105, Yuseong, Daejeon 305-360, South Korea 2: Graduate School of Biotechnology, Korea University, Seoul 136-071, South Korea 3: Division of Food Standards, Korea Food and Drug Administration, Seoul 122-704, South Korea 4: Department of Oriental Medical Food & Nutrition, Asia University of Traditional Science, Gyungsan 240-3, South Korea; Source Info: Jan2004, Vol. 69 Issue 1, p99; Subject Term: RADIATION chemistry; Subject Term: DIMETHYLNITROSAMINE; Subject Term: DICHLOROMETHANE; Subject Term: ULTRAVIOLET spectra; Author-Supplied Keyword: Gamma irradiation; Author-Supplied Keyword: N-Nitrosodimethylamine; Author-Supplied Keyword: N-Nitrosopyrrolidine; Author-Supplied Keyword: Radiolysis; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/S0969-806X(03)00330-X
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dayton, Andrew I.
T1 - Within you, without you: HIV-1 Rev and RNA export.
JO - Retrovirology
JF - Retrovirology
Y1 - 2004/01//
VL - 1
M3 - Article
SP - 35
EP - 4
PB - BioMed Central
SN - 17424690
AB - Nucleo-cytoplasmic transport of RNA is one of many cellular pathways whose illumination has progressed hand in hand with understanding of retroviral mechanisms. A recent paper in Cell reports the involvement of an RNA helicase in the pathway by which HIV exports partially spliced and unspliced RNA out of the nucleus. This suggests the ubiquity of RNA helicases in RNA export from the nucleus, and has novel mechanistic implications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Retrovirology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - RNA
KW - RETROVIRUSES
KW - ENZYMES
KW - CYTOPLASM
N1 - Accession Number: 30739083; Dayton, Andrew I. 1; Email Address: dayton@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, USA; Source Info: 2004, Vol. 1, p35; Subject Term: HIV (Viruses); Subject Term: RNA; Subject Term: RETROVIRUSES; Subject Term: ENZYMES; Subject Term: CYTOPLASM; Number of Pages: 4p; Document Type: Article
L3 - 10.1186/1742-4690-1-35
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Horn, Wade F.
AD - US Department of Health and Human Services
A2 - Moynihan, Daniel P.
A2 - Smeeding, Timothy M.
A2 - Rainwater, Lee
T1 - Marriage, Family, and the Welfare of Children: A Call for Action
T2 - The future of the family
PB - New York:
PB - Russell Sage Foundation
Y1 - 2004///
SP - 181
EP - 197
N1 - Accession Number: 0815977; Reviewed Book ISBN: 0-87154-625-6; Keywords: Children; Family; Marriage; Welfare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200602
KW - General Welfare; Well-Being I31
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Fertility; Family Planning; Child Care; Children; Youth J13
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
ID - 2003-88217-011
AN - 2003-88217-011
AU - Colligan, Michael J.
AU - Cohen, Alexander
ED - Barling, Julian
ED - Frone, Michael R.
ED - Barling, Julian, (Ed)
ED - Frone, Michael R., (Ed)
T1 - The role of training in promoting workplace safety and health.
T2 - The psychology of workplace safety.
Y1 - 2004///
SP - 223
EP - 248
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-59147-068-4
N1 - Accession Number: 2003-88217-011. Partial author list: First Author & Affiliation: Colligan, Michael J.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20031110. Correction Date: 20151221. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-59147-068-4, Hardcover. Language: English. Major Descriptor: Health Promotion; Occupational Safety; Organizational Climate; Personnel Training. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - The present chapter looks at the role of training in promoting worker safety and health from three perspectives. The first perspective deals with some of the ethical and contextual issues associated with workplace safety training. The primary concern is to examine how organizational and social/psychological considerations may affect how training is accepted and acted on in a workplace setting. The second perspective involves a review of the research literature to evaluate the efficacy of training as a safety and health intervention. Here the attempt is to identify critical components of successful training interventions with an eye toward practical recommendations. Finally, a third perspective attempts to provide some guidance for future research and program development related to workplace safety and health training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace safety
KW - training interventions
KW - health intervention
KW - worker training
KW - 2004
KW - Health Promotion
KW - Occupational Safety
KW - Organizational Climate
KW - Personnel Training
KW - 2004
DO - 10.1037/10662-011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-88217-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Wallace, Kendall B.
AU - Hausner, Elizabeth
AU - Herman, Eugene
AU - Holt, Gordon D.
AU - MacGregor, James T.
AU - Metz, Alan L.
AU - Murphy, Elizabeth
AU - Rosenblaum, I. Y.
AU - Sistare, Frank D.
AU - York, Malcolm J.
T1 - Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01//Jan/Feb2004
VL - 32
IS - 1
M3 - Article
SP - 106
EP - 121
SN - 01926233
AB - Deals with a study that considered serum troponins as biomarkers of drug-induced cardiac toxicity. Types or categories of drug-induced cardiac toxicity; Characteristics of an ideal biomarker; Information on creatine kinase, myoglobin and lactate dehydrogenase; Rationale for choosing the troponins.
KW - Biochemical markers
KW - Serum
KW - Creatine kinase
KW - Myoglobin
KW - Dehydrogenases
N1 - Accession Number: 11900906; Wallace, Kendall B. 1; Email Address: kwallace@d.umn.edu; Hausner, Elizabeth 2; Herman, Eugene 3; Holt, Gordon D. 4; MacGregor, James T. 5; Metz, Alan L. 1,6; Murphy, Elizabeth 7; Rosenblaum, I. Y. 8; Sistare, Frank D. 3; York, Malcolm J. 9; Affiliations: 1: Professor, Department of Biochemistry & Molecular Biology, University of Minnesota School of Medicine, Duluth, MN; 2: FDA Center for Drug Evaluation and Research, Rockville, MD 20852; 3: Center for Drug Evaluation and Research, FDA, Laurel, MD 20708; 4: Principal Scientist, Oxford GlycoSciences, Montgomery Village, MD 20886-1265; 5: FDA National Center for Toxicological Research, Rockville, MD 20857; 6: Drug Safety Evaluation, Global Research and Development, Ann Arbor Laboratories, Pfizer Inc., Ann Arbor, MI 48105; 7: Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709; 8: Director, General Toxicology, Drug Safety and Metabolism, Schering-Plough Research Institute, Lafayette, NJ 07848; 9: Manager, Clinical Pathology Laboratory, Preclinical Safety Sciences, GlaxoSmithKline, Hertfordshire, SG12, ODP, United Kingdom; Issue Info: Jan/Feb2004, Vol. 32 Issue 1, p106; Thesaurus Term: Biochemical markers; Subject Term: Serum; Subject Term: Creatine kinase; Subject Term: Myoglobin; Subject Term: Dehydrogenases; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 16p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1080/01926230490261302
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11900906&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Crissman, James W.
AU - Goodman, Dawn G.
AU - Hidebrandt, Paul K.
AU - Maronpot, Robert R.
AU - Prater, Donald A.
AU - Riley, Julia H.
AU - Seaman, William J.
AU - Thake, Daryl C.
T1 - Best Practices Guideline: Toxicologic Histopathology.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01//Jan/Feb2004
VL - 32
IS - 1
M3 - Article
SP - 126
EP - 131
SN - 01926233
AB - Presents a guideline released by the Society of Toxicologic Pathology for toxicologic histopathology. Definition of histopathology; Responsibilities of a pathologist; Information on histopathology as a descriptive and interpretative science; Identification of information necessary for the pathologist before microscopic evaluation commences.
KW - Toxicity testing
KW - Pathological histology
KW - Pathologists
KW - Physicians
KW - Societies
KW - best practice
KW - guideline
KW - histopathology
KW - methods
KW - microscopy
N1 - Accession Number: 11900908; Crissman, James W. 1; Goodman, Dawn G. 2; Hidebrandt, Paul K. 3; Maronpot, Robert R. 4; Prater, Donald A. 5; Riley, Julia H. 6; Seaman, William J. 7; Email Address: william.j.seaman@pfizer.com; Thake, Daryl C.; Affiliations: 1: Health & Environmental Sciences, Dow Corning Corporation, Midland, Michigan 48686; 2: Covance Laboratories Inc., Vienna, Virginia 22182; 3: Pathco Inc., Frederick, Maryland 21702; 4: Laboratory of Experimental Pathology, National Institute of Environmental Health, Research Triangle Park, North Carolina; 5: Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20855; 6: Estuary Pharmaceuticals, Cambridge, Massachusetts 02139; 7: Pfizer Inc., Kalamazoo, Michigan 49001; Issue Info: Jan/Feb2004, Vol. 32 Issue 1, p126; Thesaurus Term: Toxicity testing; Subject Term: Pathological histology; Subject Term: Pathologists; Subject Term: Physicians; Subject Term: Societies; Author-Supplied Keyword: best practice; Author-Supplied Keyword: guideline; Author-Supplied Keyword: histopathology; Author-Supplied Keyword: methods; Author-Supplied Keyword: microscopy; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 6p; Document Type: Article
L3 - 10.1080/01926230490268756
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=11900908&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-04008-001
AN - 2006-04008-001
AU - Atkins, David
T1 - Screening for Depression: Recommendations and Rationale.
JF - Internet Journal of Mental Health
JO - Internet Journal of Mental Health
JA - Internet J Ment Health
Y1 - 2004///
VL - 1
IS - 2
SP - 1
EP - 10
CY - US
PB - Internet Scientific Publications LLC
SN - 1531-2941
AD - Atkins, David, U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, 6010 Executive Boulevard, Suite 300, Rockville, MD, US, 20852
N1 - Accession Number: 2006-04008-001. Partial author list: First Author & Affiliation: Atkins, David; U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Center for Practice and Technology Assessment, Rockville, MD, US. Release Date: 20060911. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Diagnosis; Major Depression; Screening; Treatment. Classification: Affective Disorders (3211). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: 2004.
AB - The U.S. Preventive Services Task Force (USPSTF) recommends screening adults for depression in clinical practices that have systems in place to assure accurate diagnosis, effective treatment, and follow-up. The USPSTF found limited evidence on the accuracy and reliability of screening tests in children and adolescents and limited evidence on the effectiveness of therapy in children and adolescents identified in primary care settings. All positive screening tests should trigger full diagnostic interviews that use standard diagnostic criteria to determine the presence or absence of specific depressive disorders, such as major depression and/or dysthymia. Clinical practices that screen for depression should have systems in place to ensure that positive screening results are followed by accurate diagnosis, effective treatment, and careful follow-up. Depressive disorders are common, chronic and costly. Several depression screening instruments are available; most instruments have relatively good sensitivity (80% to 90%) but only fair specificity. Few studies have examined the effect of combining medications and psychotherapy. The Canadian Task Force on Preventive Health Care (CTFPHC) found fair evidence to exclude routine screening of asymptomatic individuals for depression in 1994 but suggested that clinicians maintain a high degree of clinical suspicion for depression among their patients. The USPSTF grades the quality of the overall evidence for a service on a 3-point scale (good, fair, poor). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical practices
KW - depressive disorders
KW - screening
KW - diagnosis
KW - treatment
KW - 2004
KW - Clinical Trials
KW - Diagnosis
KW - Major Depression
KW - Screening
KW - Treatment
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04008-001&site=ehost-live&scope=site
UR - datkins@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12304-001
AN - 2004-12304-001
AU - Burgdorf, Kenneth
AU - Chen, Xiaowu
AU - Walker, Tamitha
AU - Porowski, Allan
AU - Herrell, James M.
T1 - The prevalence and prognostic significance of sexual abuse in substance abuse treatment of women.
JF - Addictive Disorders & Their Treatment
JO - Addictive Disorders & Their Treatment
JA - Addict Disord Their Treat
Y1 - 2004///
VL - 3
IS - 1
SP - 1
EP - 13
CY - US
PB - Lippincott Williams & Wilkins
SN - 1531-5754
SN - 1535-1122
AD - Porowski, Allan, Caliber Associates, 10530 Rosehaven Street, Suite 400, Fairfax, VA, US, 22030
N1 - Accession Number: 2004-12304-001. Partial author list: First Author & Affiliation: Burgdorf, Kenneth; Caliber Associates, Fairfax, VA, US. Release Date: 20040419. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Sexual Abuse; Treatment Outcomes. Minor Descriptor: Parenthood Status; Pregnancy. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Female (40). Location: US. Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 13. Issue Publication Date: 2004.
AB - This paper presents findings from a longitudinal study of 3482 women who received long-term (6- to 12-month) residential substance abuse treatment in 41 federally funded treatment programs for pregnant and parenting women and their children. Consistent with previous studies, we found the prevalence of sexual abuse histories to be very high in this population (48-64%, depending on the definition), and we found many associations between sexual abuse and indicators of other maltreatment and of psychologic dysfunction- depression, anxiety, suicide attempts, prior mental health treatment episodes, etc. However, contrary to some speculation in the literature, we did not find sexual abuse associated with any reduction in treatment retention, completion, or post-treatment abstinence from drug or alcohol use. Sexually abused clients had generally positive treatment outcomes, on a par with those seen for non-abused clients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - pregnant women
KW - sexual abuse
KW - drug treatment outcomes
KW - parenting women
KW - 2004
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Sexual Abuse
KW - Treatment Outcomes
KW - Parenthood Status
KW - Pregnancy
KW - 2004
DO - 10.1097/00132576-200403000-00001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12304-001&site=ehost-live&scope=site
UR - porowski@calib.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13966-001
AN - 2004-13966-001
AU - Cavanaugh, Doreen A.
AU - Muck, Randolph D.
T1 - Editors' Introduction: Using Research to Improve Treatment for Adolescents: Findings from Two CSAT Demonstrations.
JF - Journal of Psychoactive Drugs
JO - Journal of Psychoactive Drugs
JA - J Psychoactive Drugs
Y1 - 2004/01//Jan-Mar, 2004
VL - 36
IS - 1
SP - 1
EP - 3
CY - US
PB - Haight-Ashbury Publications
SN - 0279-1072
SN - 2159-9777
AD - Cavanaugh, Doreen A., Health Policy Institute, Georgetown Public Policy Institute, Georgetown University, 1 Davol Square, Suite 103, Providence, RI, US, 02903
N1 - Accession Number: 2004-13966-001. Other Journal Title: Journal of Psychedelic Drugs. Partial author list: First Author & Affiliation: Cavanaugh, Doreen A.; Health Policy Institute, Georgetown Public Policy Institute, Georgetown University, Washington, DC, US. Other Publishers: Taylor & Francis. Release Date: 20040705. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Mental Health Services. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jan-Mar, 2004.
AB - As the momentum for knowledge of effective strategies for adolescent treatment grew, both the Substance Abuse and Mental Health Services Administration's Center for Substance Abuse Treatment (CSAT) and RWJF concluded that it was important to try to help shape these efforts. Thus, in June of 2002, RWJF and CSAT jointly sponsored a summit on adolescent substance abuse treatment. The summit addressed two tracks: clinical treatment issues, and the development of an adolescent substance abuse treatment system in the United States. This special theme issue includes eight articles addressing clinical issues raised at the summit organized broadly around four areas: client characteristics, multi-site treatment effectiveness analyses, identification of effective outpatient treatment and the effectiveness of residential treatment for youth who use heroin. This volume provides valuable information on effective strategies for treating adolescents with substance use disorders. It discusses the characteristics of clients in the treatment system and identifies strengths and limitations of specific treatment models. This knowledge provides support to the field and should encourage the dissemination and implementation of evidence-based practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent substance abuse
KW - substance abuse treatment
KW - 2004
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Mental Health Services
KW - 2004
DO - 10.1080/02791072.2004.10399718
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13966-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08776-003
AN - 2005-08776-003
AU - Manderscheid, Ronald W.
AU - Masi, Dale
AU - Watkins, George
AU - Carroll, Christopher D.
AU - Santiago-Fernández, Evelyn
T1 - The Employee Assistance Industry Alliance: Context, History and Initial Vision.
JF - Employee Assistance Quarterly
JO - Employee Assistance Quarterly
Y1 - 2004///
VL - 19
IS - 3
SP - 1
EP - 10
CY - US
PB - Haworth Press
SN - 0749-0003
AD - Watkins, George
N1 - Accession Number: 2005-08776-003. Other Journal Title: Journal of Workplace Behavioral Health. Partial author list: First Author & Affiliation: Manderscheid, Ronald W.; Survey and Analysis Branch, Federal Center for Mental Health Services (CMHS), US. Other Publishers: Taylor & Francis. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Health Care Psychology. Minor Descriptor: Drug Abuse; Epidemiology; Mental Health Services. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 10. Issue Publication Date: 2004.
AB - The employee assistance industry faces unique challenges as the behavioral health field continues to change. The following is a characterization of how collaboration is emerging around a national Employee Assistance Industry Alliance (hereafter called the Alliance) to provide leadership for the field. This article discusses the context in which the Alliance is developing and the initial vision for the Alliance. The context is divided into three components, epidemiology of disorder and care, and the Federal Substance Abuse and Mental Health Services Administration, known as SAMHSA, and the history of the Alliance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Employee Assistance Industry Alliance
KW - behavioral health
KW - epidemiology
KW - Substance Abuse and Mental Health Services Administration
KW - 2004
KW - Employee Assistance Programs
KW - Health Care Psychology
KW - Drug Abuse
KW - Epidemiology
KW - Mental Health Services
KW - 2004
DO - 10.1300/J022v19n03_01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08776-003&site=ehost-live&scope=site
UR - linyivette@yahoo.com
UR - chris.carroll1@juno.com
UR - george@prponline.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-02587-001
AN - 2005-02587-001
AU - Springer, J. Fred
AU - Sale, Elizabeth
AU - Kasim, Rafa
AU - Winter, William
AU - Sambrano, Soledad
AU - Chipungu, Sandra
T1 - Effectiveness of Culturally Specific Approaches to Substance Abuse Prevention: Findings from CSAP's National Cross-Site Evaluation of High Risk Youth Programs.
JF - Journal of Ethnic & Cultural Diversity in Social Work: Innovation in Theory, Research & Practice
JO - Journal of Ethnic & Cultural Diversity in Social Work: Innovation in Theory, Research & Practice
JA - J Ethn Cult Divers Soc Work
Y1 - 2004///
VL - 13
IS - 3
SP - 1
EP - 23
CY - US
PB - Haworth Press
SN - 1531-3204
SN - 1531-3212
AD - Springer, J. Fred, EMT Associates, Inc., 771 Oak Avenue Parkway, Folsom, CA, US, 95630
N1 - Accession Number: 2005-02587-001. Other Journal Title: Journal of Multicultural Social Work. Partial author list: First Author & Affiliation: Springer, J. Fred; EMT Associates, Inc., Folsom, CA, US. Other Publishers: Taylor & Francis. Release Date: 20050328. Correction Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Cross Cultural Psychology; Cultural Sensitivity; Drug Abuse Prevention; Treatment Effectiveness Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Literature Review; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: 2004.
AB - This study assesses the degree to which culturally specific interventions enhance substance abuse prevention effectiveness for targeted cultural groups. A large and diverse (African American, Hispanic, American Indian, and Asian) sample of 10,500 youth across 48 programs was obtained. Youth participating in culturally specific programming showed greater program satisfaction and felt programs were more personally meaningful than youth in non-culturally specific programs. Culturally specific programs for African American youth were also more effective in preventing substance use. This finding may be attributable to the fact that Africentric programs apply a comprehensive and structured approach to substance abuse prevention and that cultural messages are clearly linked to important protective factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse prevention
KW - culturally specific interventions
KW - research findings
KW - treatment effectiveness
KW - 2004
KW - Cross Cultural Differences
KW - Cross Cultural Psychology
KW - Cultural Sensitivity
KW - Drug Abuse Prevention
KW - Treatment Effectiveness Evaluation
KW - 2004
DO - 10.1300/J051v13n03_01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-02587-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2015-43007-002
AN - 2015-43007-002
AU - Wolff, Nancy
AU - Maschi, Tina
AU - Bjerklie, J. R.
T1 - Profiling mentally disordered prison inmates: A case study in new jersey.
JF - Journal of Correctional Health Care
JO - Journal of Correctional Health Care
JA - J Correct Health Care
Y1 - 2004/01//
VL - 11
IS - 1
SP - 5
EP - 29
CY - US
PB - Sage Publications
SN - 1078-3458
SN - 1940-5200
AD - Wolff, Nancy, 30 College Avenue, New Brunswick, NJ, US, 08520
N1 - Accession Number: 2015-43007-002. Partial author list: First Author & Affiliation: Wolff, Nancy; Edward J. Bloustein School of Planning & Public Policy, Center for Mental Health Services & Criminal Justice Research, NJ, US. Release Date: 20170123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Justice; Health Care Psychology; Mental Disorders; Prisoners; Risk Factors. Classification: Psychological Disorders (3210). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Clinical Case Study; Empirical Study; Interview; Quantitative Study. Page Count: 25. Issue Publication Date: Jan, 2004. Copyright Statement: National Commission on Correctional Health Care. 2004.
AB - This paper profiles the behavioral health and criminal justice characteristics of the universe of male special needs inmates (N = 2,715) in New Jersey prisons. Mentally disordered inmates were found to vary significantly and systematically in their treatment needs and their risks to the community. The lack of homogeneity within the mentally disordered inmate population suggests the need to classify need–risk clusters within the offender group, develop programs that respond to particular need–risk clusters, and match types of mentally disordered offenders to these specialized programs. Recommended is a cafeteria–style approach to treatment planning that recognizes the complexity of problem behaviors and the variation in the presentation of these problems. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - criminal justice
KW - risk factors
KW - mental disorder
KW - prison inmates
KW - behavioral health
KW - 2004
KW - Criminal Justice
KW - Health Care Psychology
KW - Mental Disorders
KW - Prisoners
KW - Risk Factors
KW - 2004
DO - 10.1177/107834580401100102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-43007-002&site=ehost-live&scope=site
UR - nwolff@ihhcpar.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20044-002
AN - 2004-20044-002
AU - Harris, Katherine M.
AU - Thomas, Cindy
T1 - Naltrexone and pharmacy benefit management.
JF - Journal of Addictive Diseases
JO - Journal of Addictive Diseases
JA - J Addict Dis
Y1 - 2004///
VL - 23
IS - 4
SP - 11
EP - 29
CY - US
PB - Haworth Press
SN - 1055-0887
SN - 1545-0848
AD - Harris, Katherine M., The Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-20044-002. PMID: 15339711 Other Journal Title: Advances in Alcohol & Substance Abuse. Partial author list: First Author & Affiliation: Harris, Katherine M.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20041108. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Rehabilitation; Health Care Delivery; Naltrexone. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Methodology: Literature Review. References Available: Y. Page Count: 19. Issue Publication Date: 2004.
AB - Naltrexone was approved by the FDA in 1994 for the treatment of alcohol dependence. Despite the potential to make treatment more effective and accessible, naltrexone use remains low by almost any measure. While many of the factors responsible for the slow pace of diffusion are unique to naltrexone and to the organization and delivery of alcohol treatment services, other factors are the same as those that affect the use of prescription medications more generally. Access to third-party coverage and formulary inclusion are necessary conditions for the adoption and diffusion of any new pharmaceutical technology. This paper describes current issues in drug benefit design and formulary coverage decisions, reviews publicly available information on naltrexone coverage by large health insurance programs and pharmaceutical benefit management companies, and examines whether drug benefit design constitutes a barrier to naltrexone use. Our review suggests that naltrexone is widely covered on public and private health plan formularies, though restrictions on use (i.e., quantity limits, prior authorization) are common. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - naltrexone
KW - alcohol rehabilitation
KW - health care delivery
KW - 2004
KW - Alcohol Rehabilitation
KW - Health Care Delivery
KW - Naltrexone
KW - 2004
DO - 10.1300/J069v23n04_02
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20044-002&site=ehost-live&scope=site
UR - kharris@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-95249-002
AN - 2004-95249-002
AU - Wechsberg, W. M.
AU - Flannery, B.
AU - Kasten, J. J.
AU - Suerken, C.
AU - Dunlap, L.
AU - Roussel, A. E.
AU - Crum, L.
AU - Murdoch, O.
AU - Diesenhaus, H.
T1 - Physicians Practicing in Methadone Treatment Programs: Who Are They and What Do They Do?
JF - Journal of Addictive Diseases
JO - Journal of Addictive Diseases
JA - J Addict Dis
Y1 - 2004///
VL - 23
IS - 2
SP - 15
EP - 31
CY - US
PB - Haworth Press
SN - 1055-0887
SN - 1545-0848
AD - Wechsberg, W. M., RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC, US, 27709-1294
N1 - Accession Number: 2004-95249-002. PMID: 15132340 Other Journal Title: Advances in Alcohol & Substance Abuse. Partial author list: First Author & Affiliation: Wechsberg, W. M.; RTI (Research Triangle Institute) International, Research Triangle Park, NC, US. Other Publishers: Taylor & Francis. Release Date: 20041018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Methadone Maintenance; Physicians; Treatment Outcomes; Treatment. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: 2004.
AB - Objective. This study examines the characteristics and roles of physicians practicing in methadone maintenance treatment programs (MTPs). Methods. Physicians and clinic directors at 172 MTPs in the United States completed surveys. MTPs were selected for study participation based on their locations (large urban, urban, or nonurban area) owner- ship status (for profit and non-profit), and size (patient capacity of 1-100, 101-300, and 300+). Weighted data were analyzed with descriptive and multivariate methods. Results. Physicians were primarily white males aged 45 or older; 44% had 10 or more years of experience working in methadone treatment. Physicians reported spending 26% of their time completing administrative tasks. Most reported that they determine dosing levels on an individual patient basis. Average maintenance dose was 69 mg/day. Conclusions. Physicians' treatment practices play a major role in overall treatment, treatment retention, and outcomes. Physicians at for-profit and large urban MTPs reported spending the most time in direct patient contact. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methadone maintenance treatment programs
KW - practicing physicians
KW - treatment retention
KW - treatment outcomes
KW - 2004
KW - Methadone Maintenance
KW - Physicians
KW - Treatment Outcomes
KW - Treatment
KW - 2004
DO - 10.1300/J069v23n02_02
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-95249-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15467-003
AN - 2004-15467-003
AU - Tonidandel, Scott
AU - Overall, John E.
AU - Smith, Fraser
T1 - Use of resampling to select among alternative error structure specifications for GLMM analyses of repeated measurements.
JF - International Journal of Methods in Psychiatric Research
JO - International Journal of Methods in Psychiatric Research
JA - Int J Methods Psychiatr Res
Y1 - 2004///
VL - 13
IS - 1
SP - 24
EP - 33
CY - US
PB - John Wiley & Sons
SN - 1049-8931
SN - 1557-0657
AD - Tonidandel, Scott, Psychology Department, Davidson College, Box 7061, Davidson, NC, US, 28035-7061
N1 - Accession Number: 2004-15467-003. PMID: 15181484 Partial author list: First Author & Affiliation: Tonidandel, Scott; Department of Psychology, Davidson College, Davidson, NC, US. Release Date: 20041025. Correction Date: 20120723. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Errors; Goodness of Fit; Maximum Likelihood; Sampling (Experimental); Statistical Correlation. Minor Descriptor: Repeated Measures. Classification: Statistics & Mathematics (2240). Population: Human (10); Outpatient (60). Tests & Measures: Hamilton Rating Scale for Depression DOI: 10.1037/t04100-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2004.
AB - Autocorrelated error and missing data due to dropouts have fostered interest in the flexible general linear mixed model (GLMM) procedures for analysis of data from controlled clinical trials. The user of these adaptable statistical tools must, however, choose among alternative structural models to represent the correlated repeated measurements. The fit of the error structure model specification is important for validity of tests for differences in patterns of treatment effects across time, particularly when maximum likelihood procedures are relied upon. Results can be affected significantly by the error specification that is selected, so a principled basis for selecting the specification is important. As no theoretical grounds are usually available to guide this decision, empirical criteria have been developed that focus on model fit . The current report proposes alternative empirical criteria that focus on bootstrap estimates of actual type I error and power of tests for treatment effects. Results for model selection before and after the blind is broken are compared. Goodness-of-fit statistics also compare favourably for models fitted to the blinded or unblinded data, although the correspondence to actual type I error and power depends on the particular fit statistic that is considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - resampling
KW - general linear mixed model
KW - error structure
KW - goodness-of-fit
KW - maximum likelihood
KW - repeated measures
KW - 2004
KW - Errors
KW - Goodness of Fit
KW - Maximum Likelihood
KW - Sampling (Experimental)
KW - Statistical Correlation
KW - Repeated Measures
KW - 2004
DO - 10.1002/mpr.161
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15467-003&site=ehost-live&scope=site
UR - sctonidandel@davidson.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21660-003
AN - 2004-21660-003
AU - Lucksted, Alicia
T1 - Lesbian, Gay, Bisexual, and Transgender People Receiving Services in the Public Mental Health System: Raising Issues.
JF - Journal of Gay & Lesbian Psychotherapy
JO - Journal of Gay & Lesbian Psychotherapy
Y1 - 2004///
VL - 8
IS - 3-4
SP - 25
EP - 42
CY - US
PB - Haworth Press
SN - 0891-7140
SN - 1540-7128
AD - Lucksted, Alicia, Center for Mental Health Services Research, University of Maryland, 685 West Baltimore Street, MSTF Building, Room 300, Baltimore, MD, US, 21201-1549
N1 - Accession Number: 2004-21660-003. Other Journal Title: Journal of Gay & Lesbian Mental Health. Partial author list: First Author & Affiliation: Lucksted, Alicia; Center for Mental Health Services Research, University of Maryland, Baltimore, MD, US. Other Publishers: Taylor & Francis. Release Date: 20050103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Homosexuality; Lesbianism; Mental Health Services; Psychotherapy; Public Health Services. Minor Descriptor: Bisexuality; Transsexualism. Classification: Health & Mental Health Services (3370). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 18. Issue Publication Date: 2004.
AB - The growing literature about psychotherapy with LGBT clients rarely addresses serious mental illnesses or mental health care settings such as inpatient, psychosocial rehabilitation, day programs, or residential care. Nor does much of existing literature address the public mental health system. In 1997, the federal Center for Mental Health Services (part of Substance Abuse and Mental Health Services Administration and the federal Department of Health and Human Services) commissioned a review of current knowledge regarding the experiences, needs, and recommendations of LGBT people with serious mental illnesses. This article offers a summary of that multi-year project. Using qualitative methods and analysis, this study combines information from archival sources, published and unpublished literature, and key informant interviews to highlight questions and themes important to the welfare of lesbian, gay, bisexual and transgender (LGBT) people receiving public/community mental health services. This paper raises issues about the experiences and needs of these populations that would benefit from further investigation, to help pique further inquiry, and to suggest constructive interim steps. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - homosexuality
KW - psychotherapy
KW - residential care
KW - lesbian
KW - gay
KW - bisexual and transgender community
KW - 2004
KW - Homosexuality
KW - Lesbianism
KW - Mental Health Services
KW - Psychotherapy
KW - Public Health Services
KW - Bisexuality
KW - Transsexualism
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21660-003&site=ehost-live&scope=site
UR - aluckste@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08776-005
AN - 2005-08776-005
AU - Daniels, Allen
AU - Teems, Lisa
AU - Carroll, Christopher D.
AU - Santiago-Fernández, Evelyn
T1 - Crossing the Quality Chasm: Opportunities for the Employee Assistance Program Field.
JF - Employee Assistance Quarterly
JO - Employee Assistance Quarterly
Y1 - 2004///
VL - 19
IS - 3
SP - 27
EP - 43
CY - US
PB - Haworth Press
SN - 0749-0003
AD - Daniels, Allen
N1 - Accession Number: 2005-08776-005. Other Journal Title: Journal of Workplace Behavioral Health. Partial author list: First Author & Affiliation: Daniels, Allen; University of Cincinnati, Cincinnati, OH, US. Other Publishers: Taylor & Francis. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Health; Health Care Psychology; Job Performance; Values. Minor Descriptor: Alcoholism. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 17. Issue Publication Date: 2004.
AB - The core services and values of Employee Assistance Programs (EAPs) have undergone many changes throughout their six-decade history. Originally designed as an occupational resource to address workforce performance and impairment due to alcoholism, the field has expanded into a more comprehensive range of behavioral health services. In the wake of these changes, the field finds itself in search of a true identity so that it can survive as a distinct profession. This article proposes a new quality framework for guiding the future direction of the EAP field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Employee Assistance Program
KW - values
KW - workforce performance
KW - impairment
KW - alcoholism
KW - behavioral health services
KW - 2004
KW - Employee Assistance Programs
KW - Health
KW - Health Care Psychology
KW - Job Performance
KW - Values
KW - Alcoholism
KW - 2004
DO - 10.1300/J022v19n03_03
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08776-005&site=ehost-live&scope=site
UR - linyivette@yahoo.com
UR - chris.carroll1@juno.com
UR - Lisa.Teems@HHS.gov
UR - Allen.daniels@uc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11598-005
AN - 2004-11598-005
AU - Stubbs-Wynn, Phyllis E.
AU - Krajicek, Marilyn J.
AU - Hamilton, Barbara
AU - Collins, Shannon
AU - Torrey, Virginia
AU - Ekegren, Kathryn
ED - Ekegren, Kathryn
T1 - SIDS Risk-Reduction Language in State Childcare Regulations as of July 2002: Lessons Learned.
JF - Journal for Specialists in Pediatric Nursing
JO - Journal for Specialists in Pediatric Nursing
JA - J Spec Pediatr Nurs
Y1 - 2004/01//Jan-Mar, 2004
VL - 9
IS - 1
SP - 32
EP - 36
CY - United Kingdom
PB - Blackwell Publishing
SN - 1539-0136
SN - 1744-6155
AD - Krajicek, Marilyn J.
N1 - Accession Number: 2004-11598-005. PMID: 15040280 Other Journal Title: Journal of the Society of Pediatric Nurses; Maternal-Child Nursing Journal. Partial author list: First Author & Affiliation: Stubbs-Wynn, Phyllis E.; Infant and Child Health Branch, Maternal and Child Health Bureau, Department of Health and Human Services, Aurora, CO, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Policy Making; Sudden Infant Death; Syndromes. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Jan-Mar, 2004.
AB - Sudden infant death syndrome (SIDS) is the sudden death of an infant under I year of age that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. States are reporting progress in incorporating SIDS risk reduction language into their regulations and are training providers on the significance of complying with such regulations. There has been a significant reduction in SIDS deaths, since the introduction of the AAP Back to Sleep recommendations in 1992, and the subsequent informational campaigns. It is accepted that the practice of Back to Sleep comes at no cost to consumers, providers, or policymakers, with the enormous benefit of protecting infants from SIDS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sudden infant death syndrome
KW - clinical history
KW - 2004
KW - Child Care
KW - Policy Making
KW - Sudden Infant Death
KW - Syndromes
KW - 2004
DO - 10.1111/j.1088-145X.2004.00032.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11598-005&site=ehost-live&scope=site
UR - marilyn.krajicek@uchsc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11215-005
AN - 2004-11215-005
AU - Reynolds, Brady
AU - Richards, Jerry B.
AU - Horn, Kimberly
AU - Karraker, Katherine
T1 - Delay discounting and probability discounting as related to cigarette smoking status in adults.
JF - Behavioural Processes
JO - Behavioural Processes
JA - Behav Processes
Y1 - 2004/01//
VL - 65
IS - 1
SP - 35
EP - 42
CY - Netherlands
PB - Elsevier Science
SN - 0376-6357
SN - 1872-8251
AD - Reynolds, Brady, Department of Psychiatry, University of Chicago, MC3077, 5841 S. Maryland Avenue, Chicago, IL, US, 60637
N1 - Accession Number: 2004-11215-005. PMID: 14744545 Partial author list: First Author & Affiliation: Reynolds, Brady; National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20040405. Correction Date: 20160414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Monetary Rewards; Tobacco Smoking; Delay Discounting. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Sensation Seeking Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2004.
AB - This study examined relations between adult smokers and non-smokers and the devaluation of monetary rewards as a function of delay (delay discounting, DD) or probability (probability discounting, PD). The extent to which individuals discount value, either as a function of a reward being delayed or probabilistic, has been taken to reflect individual differences in impulsivity. Those who discount most are considered most impulsive. Previous research has shown that adult smokers discount the value of delayed rewards more than adult non-smokers. However, in the one published study that examined probability discounting in adult smokers and non-smokers, the smokers did not discount the value of probabilistic rewards more than the non-smoker controls. From this past research, it was hypothesized that measures of delay discounting would differentiate between smokers and non-smokers but that probability discounting would not. Participants were 54 adult smokers and non-smokers. The smokers all reported smoking at least 20 cigarettes per day, and the non-smokers reported having never smoked. The results indicated that the smokers discounted significantly more than the non-smokers by both delay and probability. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - delay discounting
KW - probability discounting
KW - cigarette smoking
KW - monetary rewards
KW - 2004
KW - Monetary Rewards
KW - Tobacco Smoking
KW - Delay Discounting
KW - 2004
DO - 10.1016/S0376-6357(03)00109-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11215-005&site=ehost-live&scope=site
UR - breynold@yoda.bsd.uchicago.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12523-005
AN - 2004-12523-005
AU - Fisher, William H.
AU - Normand, Sharon-Lise T.
AU - Dickey, Barbara
AU - Packer, Ira K.
AU - Grudzinskas, Albert J.
AU - Azeni, Hocine
T1 - Managed mental health care's effects on arrest and forensic commitment.
JF - International Journal of Law and Psychiatry
JO - International Journal of Law and Psychiatry
JA - Int J Law Psychiatry
Y1 - 2004/01//Jan-Feb, 2004
VL - 27
IS - 1
SP - 65
EP - 77
CY - Netherlands
PB - Elsevier Science
SN - 0160-2527
SN - 1873-6386
AD - Fisher, William H., Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School (UMMS), 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2004-12523-005. PMID: 15019768 Partial author list: First Author & Affiliation: Fisher, William H.; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School (UMMS), Worcester, MA, US. Release Date: 20040906. Correction Date: 20170206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Justice; Forensic Psychiatry; Legal Arrest; Managed Care; Health Care Policy. Minor Descriptor: Mentally Ill Offenders. Classification: Health & Mental Health Services (3370); Forensic Psychology & Legal Issues (4200). Population: Human (10). Location: US. References Available: Y. Page Count: 13. Issue Publication Date: Jan-Feb, 2004.
AB - Reducing the use of inpatient treatment has been a consistent theme of American mental health policy for the last half century and, over that time, has been the focus of numerous service system interventions. Among these was passage of reformed civil commitment statutes by state legislatures across the country. In seeking to determine whether an inadvertent criminalization process has been triggered by Medicaid managed care, attention should be focused on pre-post managed care trends in crossover from the mental health system to the criminal justice and forensic evaluation systems. Such crossover could manifest itself in two ways: increased likelihood of arrest and/or increased likelihood that arrestees would be committed to the forensic mental health system. To examine the extent of any such crossover, we developed and evaluated three hypothetical scenarios. The first is the null hypothesis that managed care had no effect on either arrest or forensic commitment. The second posits a generalized postmanaged care increase in criminal justice and forensic system involvement among clients of the mental health system. The third scenario envisions that, in the postmanaged care era, clients of the mental health system who are Medicaid beneficiaries were at greater risk for either arrest or forensic commitment. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - criminal justice
KW - forensic mental health system
KW - managed mental health care
KW - forensic commitment
KW - civil commitment statutes
KW - mental health policy
KW - legal arrest
KW - 2004
KW - Criminal Justice
KW - Forensic Psychiatry
KW - Legal Arrest
KW - Managed Care
KW - Health Care Policy
KW - Mentally Ill Offenders
KW - 2004
DO - 10.1016/j.ijlp.2003.12.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12523-005&site=ehost-live&scope=site
UR - Bill.Fisher@Umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11202-002
AN - 2004-11202-002
AU - Itzhak, Yossef
AU - Achat-Mendes, Cindy N.
AU - Ali, Syed F.
AU - Anderson, Karen L.
T1 - Long-lasting behavioral sensitization to psychostimulants following p-chloroamphetamine-induced neurotoxicity in mice.
JF - Neuropharmacology
JO - Neuropharmacology
JA - Neuropharmacology
Y1 - 2004/01//
VL - 46
IS - 1
SP - 74
EP - 84
CY - Netherlands
PB - Elsevier Science
SN - 0028-3908
SN - 1873-7064
AD - Itzhak, Yossef, Department of Psychiatry and Behavioral Sciences (K-629), University of Miami School of Medicine, Gautier Building Room no. 503, 1011 NW 15th Street,, Miami, FL, US, 33136
N1 - Accession Number: 2004-11202-002. PMID: 14654099 Other Journal Title: International Journal of Neuropharmacology. Partial author list: First Author & Affiliation: Itzhak, Yossef; Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, US. Release Date: 20050131. Correction Date: 20130506. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amphetamine; Animal Locomotion; Cocaine; Methylenedioxymethamphetamine; Neurotoxicity. Minor Descriptor: Drug Sensitivity; Mice. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan, 2004.
AB - Amphetamine analogs such as p-chloroamphetamine (PCA) cause serotonergic and dopaminergic neurotoxicity. The behavioral consequences and the responsiveness to psychostimulants following the neurotoxic insult are unclear. The present study was undertaken to investigate the outcome of neurotoxic and non-neurotoxic PCA pre-treatments on the sensitivity of Swiss Webster mice to the psychomotor stimulating effects of PCA, 3,4-methylenedioxymethamphetamine (MDMA) and cocaine. PCA (15 mg/kg x 2; i.p.) caused 37-70% depletion of dopaminergic and serotonergic markers in mouse brain. Saline and PCA (15 mg/kg x 2) mice were challenged on days 5, 12, 40 and 74 with one of the following drugs: PCA (5 mg/kg), MDMA (10 mg/kg) and cocaine (20 mg/kg). The PCA pre-exposed mice showed marked locomotor sensitization from days 5-74 to all three drugs tested. The time course of the sensitized response coincided with the time course of the neurotoxic insult as determined by reduced densities of striatal dopamine transporter and frontal cortex serotonin transporter binding sites. A single injection of PCA (5 mg/kg) caused neither neurotoxicity nor sensitization to the locomotor stimulating effects of PCA, MDMA and cocaine. Repeated administration of a low non-neurotoxic dose of PCA (5 mg/kg/day; 6 days) caused a transient locomotor sensitization to PCA that dissipated after one month. Results of the present study suggest that PCA-induced serotonergic and dopaminergic neurotoxicity coincides with long-lasting locomotor sensitization to psychostimulants. These findings may be relevant to the psychopathology of amphetamines-induced neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - locomotor sensitization
KW - cocaine
KW - psychomotor stimulation effects
KW - mice
KW - p-Chloroamphetamine
KW - neurotoxicity
KW - locomotor activity
KW - ecstacy
KW - MDMA
KW - 2004
KW - Amphetamine
KW - Animal Locomotion
KW - Cocaine
KW - Methylenedioxymethamphetamine
KW - Neurotoxicity
KW - Drug Sensitivity
KW - Mice
KW - 2004
DO - 10.1016/S0028-3908(03)00316-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11202-002&site=ehost-live&scope=site
UR - yitzhak@med.miami.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10921-008
AN - 2004-10921-008
AU - Brady, Thomas M.
AU - Krebs, Christopher P.
AU - Laird, Glen
T1 - Psychiatric Comorbidity and Not Completing Jail-based Substance Abuse Treatment.
JF - The American Journal on Addictions
JO - The American Journal on Addictions
JA - Am J Addict
Y1 - 2004/01//Jan-Feb, 2004
VL - 13
IS - 1
SP - 83
EP - 101
CY - United Kingdom
PB - Taylor & Francis
SN - 1055-0496
SN - 1521-0391
AD - Brady, Thomas M., Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 5600 Fishers Lane, Room 16-105, Rockville, MD, US, 20857
N1 - Accession Number: 2004-10921-008. PMID: 14766441 Partial author list: First Author & Affiliation: Brady, Thomas M.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Informa Healthcare; Wiley-Blackwell Publishing Ltd. Release Date: 20040308. Correction Date: 20100111. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Rehabilitation; Mental Disorders; Mentally Ill Offenders; Treatment Dropouts. Minor Descriptor: Drug Abuse; Prisoners; Retention. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Methodology: Empirical Study; Literature Review; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Jan-Feb, 2004.
AB - Many jail inmates have a history of mental illness, substance use, and drug-related crime. This article assesses the effect of psychiatric comorbidity on retention in jail-based substance abuse treatment. Secondary data from five jail-based substance abuse treatment programs were studied using descriptive and multivariate analyses. Controlling for age, sex, race, education, and program, the odds of an offender with a history of mental illness being terminated from treatment were nearly three times that of those with no such history. The data suggest that psychiatric comorbidity may be an important correlate of retention in jail-based substance abuse treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric comorbidity
KW - jail-based substance abuse treatment
KW - mental illness
KW - treatment retention
KW - 2004
KW - Comorbidity
KW - Drug Rehabilitation
KW - Mental Disorders
KW - Mentally Ill Offenders
KW - Treatment Dropouts
KW - Drug Abuse
KW - Prisoners
KW - Retention
KW - 2004
DO - 10.1080/10550490490265398
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10921-008&site=ehost-live&scope=site
UR - tbrady@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12149-009
AN - 2004-12149-009
AU - Ferguson, Sherry A.
AU - Cada, Amy M.
T1 - Developmental treatment with difluoromethylornithine has few effects on behavior or body weight in Sprague-Dawley rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2004/01//Jan-Feb, 2004
VL - 26
IS - 1
SP - 83
EP - 93
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Ferguson, Sherry A., HFT-132, Division of Neuntoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2004-12149-009. PMID: 15001217 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; National Center for Toxicological Research/FDA, Division of Neurotoxicology, HFT-132, Jefferson, AR, US. Release Date: 20050321. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Ethology; Neonatal Development; Neural Development; Neurotoxicity; Teratogens. Minor Descriptor: Cerebellum; Rats; Startle Reflex. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan-Feb, 2004.
AB - Developmental difluoromethylornithine (DFMO) treatment reduces cerebellar weight, but the functional alterations resulting from this have been little investigated. Here, Sprague-Dawley rats were subcutaneously injected with 500 mg/kg DFMO on postnatal days (PNDs) 5-12 and a comprehensive set of behavioral assessments measured early developmental behaviors (righting reflex, negative geotaxis), motor coordination, acoustic startle, short- and long-term activity, social behaviors, anxiety, and spatial learning and memory. DFMO treatment appeared to cause a decreased latency to perform the negative geotaxis behavior on PNDs 8-10 and increased latency to hang by the forelimbs on PNDs 12-14. Our previous study did not indicate similar effects, but age at testing differed between the two studies. DFMO treatment caused a decreased latency to maximum acoustic startle response in both the acoustic startle paradigm and in the pulse-alone trials of the prepulse inhibition test. This DFMO treatment paradigm induced a 10% decrease in adult cerebellar weight, but the results here imply that such developmental stunting has few functional alterations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - postnatal difluoromethylornithine
KW - rats
KW - behavioral assessments
KW - early developmental behaviors
KW - cerebellar weight
KW - 2004
KW - Animal Ethology
KW - Neonatal Development
KW - Neural Development
KW - Neurotoxicity
KW - Teratogens
KW - Cerebellum
KW - Rats
KW - Startle Reflex
KW - 2004
DO - 10.1016/j.ntt.2003.08.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12149-009&site=ehost-live&scope=site
UR - sferguson@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15318-005
AN - 2004-15318-005
AU - Kass-Bartelmes, Barbara L.
AU - Hughes, Ronda
T1 - Advance Care Planning: Preferences for Care at the End of Life.
JF - Journal of Pain & Palliative Care Pharmacotherapy
JO - Journal of Pain & Palliative Care Pharmacotherapy
JA - J Pain Palliat Care Pharmacother
Y1 - 2004///
VL - 18
IS - 1
SP - 87
EP - 109
CY - US
PB - Haworth Press
SN - 1536-0288
SN - 1536-0539
N1 - Accession Number: 2004-15318-005. PMID: 15148012 Other Journal Title: Journal of Pharmaceutical Care in Pain & Symptom Control. Partial author list: First Author & Affiliation: Kass-Bartelmes, Barbara L.; Agency for Health Care Research and Quality (AHRQ), U.S. Public Health Service, US. Other Publishers: Informa Healthcare; Taylor & Francis. Release Date: 20050131. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Advance Directives; Client Attitudes; Terminally Ill Patients; Treatment Planning. Minor Descriptor: Preferences. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: 2004.
AB - (The paper was first published in Issue Number 12 of Research in Action published by the Agency for Healthcare Research and Quality, Public Health Service, U.S. Department of Health and Human Services, March 2003.) Predictors of patient wishes and influence of family and clinicians are discussed. Research findings on patient decision-making relating to preferences in end-of-life care are described. Advance directives and durable powers of attorney are defined and differentiated. Most patients have not participated in advance care planning and the need for more effective planning is documented. Appropriate times for discussions of such planning are described. Scenarios discussed include terminal cancer, chronic obstructive pulmonary disease, AIDS, stroke, and dementia. Patient satisfaction is discussed, as is a structured process for discussions about patient preferences. Results of patient responses to hypothetical scenarios are described. Invasiveness of interventions, prognosis and other factors that favor or discourage patient preferences for treatment are discussed. Findings resulting from research funded by the Agency for Healthcare Research and Quality (AHRQ) are discussed. This research can help providers offer end-of-life care based on preferences held by the majority of patients under similar circumstances. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient preferences
KW - end-of-life care
KW - patient responses
KW - advance care planning
KW - patient satisfaction
KW - advance directives
KW - effective planning
KW - 2004
KW - Advance Directives
KW - Client Attitudes
KW - Terminally Ill Patients
KW - Treatment Planning
KW - Preferences
KW - 2004
DO - 10.1300/J354v18n01_08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15318-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11887-011
AN - 2004-11887-011
AU - Prince, Mary M.
AU - Colligan, Michael J.
AU - Stephenson, Carol Merry
AU - Bischoff, B. J.
T1 - The contribution of focus groups in the evaluation of hearing conservation program (HCP) effectiveness.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2004///
VL - 35
IS - 1
SP - 91
EP - 106
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Prince, Mary M., Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Colombia Parkway, MSR 16, Cincinnati, OH, US, 45226
N1 - Accession Number: 2004-11887-011. PMID: 14992850 Partial author list: First Author & Affiliation: Prince, Mary M.; Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, US. Release Date: 20050307. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hearing Disorders; Noise Levels (Work Areas); Occupational Safety; Prevention; Program Evaluation. Minor Descriptor: Business and Industrial Personnel. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Interview; Focus Group; Qualitative Study. References Available: Y. Page Count: 16. Issue Publication Date: 2004.
AB - Problem: Exclusive reliance on such practices as policy review, audiometric testing audits, and noise surveillance to evaluate the effectiveness of workplace hearing conservation programs (HCP) fails to capture the impact of these programs as experienced by workers at the 'shop floor' and offers little insight into the reasons and potential remedies for noted deficiencies. Methods: A qualitative approach for evaluating industrial HCPs (and their various components) is discussed using three industrial populations as case studies. For each study population, this paper illustrates how focus groups, comprised of line workers and supervisors, were used to clarify and augment information gathered through more traditional program assessments to provide a more enriched picture of hearing conservation practices. Descriptive data on plant hearing conservation program practices at each plant are presented with a comparison of proactive elements of each program relative to the Occupational Safety and Health Administration (OSHA) Hearing Conservation Amendment (HCA) requirement and to internal plant policy. Results: Yearly program evaluation with input from all end-users is important in the process of hearing loss prevention. The qualitative assessment outlined in this paper serves as a basis for future quantitative assessments of HCP effectiveness using hearing threshold data and noise exposure assessments to examine changes in hearing levels as a function of noise exposure and other risk factors for hearing loss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hearing conservation program
KW - workers
KW - workplace
KW - noise exposure
KW - hearing loss prevention
KW - program evaluation
KW - 2004
KW - Hearing Disorders
KW - Noise Levels (Work Areas)
KW - Occupational Safety
KW - Prevention
KW - Program Evaluation
KW - Business and Industrial Personnel
KW - 2004
DO - 10.1016/j.jsr.2003.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11887-011&site=ehost-live&scope=site
UR - mprince@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08776-009
AN - 2005-08776-009
AU - Thompson, Christina
AU - Haught, Steven
AU - Williams, Charlie
T1 - Subject Matter Experts Invited to Speak to the Employee Assistance Industry Alliance.
JF - Employee Assistance Quarterly
JO - Employee Assistance Quarterly
Y1 - 2004///
VL - 19
IS - 3
SP - 99
EP - 109
CY - US
PB - Haworth Press
SN - 0749-0003
AD - Thompson, Christina
N1 - Accession Number: 2005-08776-009. Other Journal Title: Journal of Workplace Behavioral Health. Partial author list: First Author & Affiliation: Thompson, Christina; Employee Assistance Programs and Addictions Services, Magellan Health Services, Employer Solutions Division Strategic Business Unit, US. Other Publishers: Taylor & Francis. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Health Care Psychology. Minor Descriptor: Crisis Intervention; Drug Abuse; Mental Health Services; Stress Management. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Page Count: 11. Issue Publication Date: 2004.
AB - The Employee Assistance Industry Alliance (The Alliance) addresses a range of behavioral health topics and issues that are important to the employee assistance field. To aid in that mission, subject matter experts are often invited to attend the meetings and asked to give presentations on issues of interest to the employee assistance community. Highlighted in this paper is a summary of some of the subject matter experts that attended The Alliance meetings, along with the topics they presented on. Dr. Manderscheid convened the first Alliance meeting. His presentation focused on the responsibility of employers to make certain their EAPs effectively coordinate quality mental health and substance abuse services for employees and families in need. Majella Uzan, President of World Strategic Partners, spoke about the following year's Mental Health Forum in Geneva. Dr. Mitchell's presentation contained an overview of the International Critical Incident Stress Foundation, formed in November 1989, and the Critical Incident Stress Management Program (CISM)-both of which have provided crisis intervention/ stress management training to 30,000 to 50,000 people a year in 28 countries. He stressed the need for standardization in training approaches for managing traumatic stress and discussed prioritizing services in relation to the degree of trauma experienced. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Employee Assistance Industry Alliance
KW - behavioral health
KW - mental health services
KW - substance abuse services
KW - crisis intervention
KW - stress management training
KW - 2004
KW - Employee Assistance Programs
KW - Health Care Psychology
KW - Crisis Intervention
KW - Drug Abuse
KW - Mental Health Services
KW - Stress Management
KW - 2004
DO - 10.1300/J022v19n03_07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08776-009&site=ehost-live&scope=site
UR - charlie.williams@samhsa.hhs.gov
UR - steve@afscmeillinois.org
UR - ththompson@magellanhealth.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18954-001
AN - 2004-18954-001
AU - Erickson, Jill Shepard
T1 - Preface.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 2004///
VL - 11
IS - 2
SP - vi
EP - viii
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
AD - Erickson, Jill Shepard, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Suite 11-C-16, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-18954-001. Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Erickson, Jill Shepard; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockvillle, MD, US. Release Date: 20041101. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Health Service Needs; Mental Health; Program Evaluation; Health Care Policy. Minor Descriptor: Health Care Delivery. Classification: Community & Social Services (3373). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: 2004.
AB - Presents a preface for the journal 'American Indian & Alaska Native Mental Health Research.' The story of the Circles of Care (CoC) initiative is one that demonstrates the power of thoughtful collaboration for addressing critical health policy issues. It represents the collective vision of a large number of tribal members, service providers, advocates, researchers, and federal agency representatives who met as an Advisory Board to Center for Mental Health Services (CMHS) regarding potential initiatives to address the unique mental health needs of American Indian and Alaska Native children, adolescents, and their families. Beginning in 1994, the Advisory Board met over a period of 4 years to develop consensus for the overall design of the project. The initiative bridges the gap from 'service to science' by utilizing a community-based evaluation effort that identifies community needs, barriers to accessing services, service system gaps, local protocols for the inclusion of traditional healing, and the potential community and outside resources available to address mental health needs. This comprehensive evaluation effort enables Circles of Care grantees to develop model systems of care that are consistent with community needs and values and feasible given community resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - Circles of Care
KW - health service providers
KW - health policy
KW - mental health needs
KW - community services
KW - 2004
KW - Community Mental Health Services
KW - Health Service Needs
KW - Mental Health
KW - Program Evaluation
KW - Health Care Policy
KW - Health Care Delivery
KW - 2004
DO - 10.5820/aian.1102.2004.pf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18954-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15326-003
AN - 2004-15326-003
AU - Goldcamp, Michael
AU - Hendricks, Kitty J.
AU - Myers, John R.
T1 - Farm fatalities to youth 1995-2000: A comparison by age groups.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2004///
VL - 35
IS - 2
SP - 151
EP - 157
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Goldcamp, Michael
N1 - Accession Number: 2004-15326-003. PMID: 15178233 Partial author list: First Author & Affiliation: Goldcamp, Michael; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20050131. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Agricultural Workers; Mortality Rate; Occupational Safety. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 2004.
AB - Problem: Although a myriad of research illustrates the safety issues related to farm fatalities in youth populations, very little empirical evidence exists that includes work and non-work related farm fatalities to all youths under 20 years of age at the national level. Methods: This research will use death certificate data for the six years from 1995 to 2000 that were collected by NIOSH from all 50 state vital statistics registries. Demographic data from the 1998 CAIS were used in rate calculations. In addition to providing annual fatality rates and descriptions of the general causes of death, this research will examine the variation between age groups. Results: Analysis of 695 total farm-related youth fatalities shows an average annual fatality rate of 9.3 fatalities per 100,000 youths. Males account for 80% of these fatalities. The most prevalent causes of death are: machinery (25%), motor vehicle (17%), drowning (16%), suicide (8%) and homicide (6%). Of all youth fatalities occurring while at work, 45% are to youths less than 16 years of age. This same age group accounts for 71% of all non-work related fatalities. Summary: This research will provide farm families and researchers more detailed information on farm hazards that contribute to the deaths of youths. As these youths may encounter hazards while working or playing in their daily environment, identification and elimination of these hazards will increase overall safety on the farm. This research also indicates the need to include youths under 16 years of age in future comprehensive farm safety research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - farm fatalities
KW - age groups
KW - safety issues
KW - 2004
KW - Age Differences
KW - Agricultural Workers
KW - Mortality Rate
KW - Occupational Safety
KW - 2004
DO - 10.1016/j.jsr.2003.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15326-003&site=ehost-live&scope=site
UR - ehg8@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20432-006
AN - 2004-20432-006
AU - Bellamy, Nikki D.
AU - Springer, U. Fred
AU - Sale, Elizabeth W.
AU - Espiritu, Rachele C.
T1 - Structuring a multi-site evaluation for youth mentoring programs to prevent teen alcohol and drug use.
JF - Journal of Drug Education
JO - Journal of Drug Education
JA - J Drug Educ
Y1 - 2004///
VL - 34
IS - 2
SP - 197
EP - 212
CY - US
PB - Baywood Publishing
SN - 0047-2379
SN - 1541-4159
AD - Bellamy, Nikki D., DKASI/CSAP, SAMHSA, Room 4-1005, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2004-20432-006. PMID: 15638219 Partial author list: First Author & Affiliation: Bellamy, Nikki D.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20041206. Correction Date: 20150126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Alcohol Drinking Attitudes; Drug Abuse Prevention; Program Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: 2004.
AB - Despite mentoring's rapidly increasing popularity as an intervention for the prevention of teen alcohol and drug abuse and associated problems, there is little research consensus on its overall effectiveness or on the core principles and components that define effective mentoring. To advance knowledge concerning this important prevention intervention, the Center for Substance Abuse Prevention has designed and funded a multi-site cooperative agreement involving seven mentoring programs. The programs are designed to provide a rigorous outcome evaluation that allows comparisons of differing approaches to organizing and delivering mentoring services to adolescents at high risk for substance abuse. The cooperative agreement guidelines set service parameters and options that focus on issues that are grounded in past research on mentoring prevention interventions. The cooperative agreement includes a quasi-experimental, longitudinal multi-site evaluation that provides evidence-based recommendations to advance the effective use of mentoring as a prevention strategy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - youth mentoring program
KW - program evaluation
KW - teen alcohol use
KW - teen drug use
KW - drug use prevention
KW - 2004
KW - Adolescent Attitudes
KW - Alcohol Drinking Attitudes
KW - Drug Abuse Prevention
KW - Program Evaluation
KW - 2004
DO - 10.2190/X4PA-BD0M-WACM-MWX9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20432-006&site=ehost-live&scope=site
UR - nikki.bellamy@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19325-002
AN - 2004-19325-002
AU - Grudzinskas, Albert J. Jr.
AU - Clayfield, Jonathan C.
T1 - Mental Health Courts and the Lesson Learned in Juvenile Court.
JF - Journal of the American Academy of Psychiatry and the Law
JO - Journal of the American Academy of Psychiatry and the Law
JA - J Am Acad Psychiatry Law
Y1 - 2004///
VL - 32
IS - 3
SP - 223
EP - 227
CY - US
PB - American Academy of Psychiatry & the Law
SN - 1093-6793
SN - 1943-3662
AD - Grudzinskas, Albert J. Jr., Law and Psychiatry Program, University of Massachusetts Medical School, 55 Lake Avenue North, WSH-8B-23, Worcester, MA, US, 01655
N1 - Accession Number: 2004-19325-002. PMID: 15515908 Other Journal Title: Bulletin of the American Academy of Psychiatry & the Law. Partial author list: First Author & Affiliation: Grudzinskas, Albert J. Jr.; Law and Coordinator of Legal Studies, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20041101. Correction Date: 20161201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adjudication; Criminal Justice; Juvenile Delinquency; Mental Health Services; Mentally Ill Offenders. Minor Descriptor: Criminal Behavior. Classification: Criminal Law & Adjudication (4230). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: 2004.
AB - The article presents information on the juvenile courts. Well-meaning members of the criminal justice system had developed a court process intent on helping juveniles, rather than punishing them as criminal offenders. Since there was no criminal adjudication, and anonymity was generally assured, it was believed that the niceties of procedural due process could be ignored. The current crisis of the 'criminalization of the mentally ill,' a term recognized in social science literature since 1972, is said to have its origins in the 'deinstitutionalization' movement of the 1950s. The phenomenon, however, was first recognized in the 1930s by L.S. Penrose. He found that in the European countries he studied, a low number of persons committed to the mental health system corresponded to a high number of persons committed to the prison system and vice versa. In general, this approach attributes the cause of criminal behavior among the mentally ill to the inadequacy of mental health services. The solution to the growing number of persons with mental illness in the criminal justice system requires research into the precipitant factors in their offending behavior and a commitment on the part of treaters, attorneys, and, in particular, legislatures and electorates to provide funding for adequate community-based services to address the mental health needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - criminal justice system
KW - juvenile court
KW - mentally ill
KW - criminal offenders
KW - mental health services
KW - 2004
KW - Adjudication
KW - Criminal Justice
KW - Juvenile Delinquency
KW - Mental Health Services
KW - Mentally Ill Offenders
KW - Criminal Behavior
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19325-002&site=ehost-live&scope=site
UR - al.grudzinskas@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10602-015
AN - 2004-10602-015
AU - Tunis, Sean R.
AU - Stryer, Daniel B.
T1 - 'Realizing the Benefits of Practical Clinical Trials': Comment.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2004/01//
VL - 291
IS - 4
SP - 426
EP - 426
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
N1 - Accession Number: 2004-10602-015. Partial author list: First Author & Affiliation: Tunis, Sean R.; Center for Medicare & Medicaid Services, Baltimore, MD, US. Release Date: 20040308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Clinical Judgment (Not Diagnosis); Clinical Trials; Decision Making; Health Care Delivery; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Issue Publication Date: Jan, 2004.
AB - Replies to the comment by J. J. Ofman and D. P. Lubeck (see record [rid]2004-10602-014[/rid]). The authors agree that the production of high-quality evidence will not by itself influence the decisions of consumers, clinicians, and policy makers. Clearly there is also a need for organizational strategies and systems that will increase the use of clinical interventions proven to be effective. Many public and private health care organizations are devoting considerable attention and resources to the measurement and improvement of health care quality. We agree with Ofman and Lubeck that the support of the pharmaceutical and medical device industry in this endeavor will be essential. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care quality
KW - practical clinical trials
KW - health policy
KW - decision making
KW - 2004
KW - Clinical Judgment (Not Diagnosis)
KW - Clinical Trials
KW - Decision Making
KW - Health Care Delivery
KW - Health Care Policy
KW - 2004
DO - 10.1001/jama.291.4.426-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10602-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03578-004
AN - 2005-03578-004
AU - Greenfield, Lawrence
AU - Burgdorf, Kenneth
AU - Chen, Xiaowu
AU - Porowski, Allan
AU - Roberts, Tracy
AU - Herrell, James
T1 - Effectiveness of Long-Term Residential Substance Abuse Treatment for Women: Findings from Three National Studies.
JF - The American Journal of Drug and Alcohol Abuse
JO - The American Journal of Drug and Alcohol Abuse
JA - Am J Drug Alcohol Abuse
Y1 - 2004///
VL - 30
IS - 3
SP - 537
EP - 550
CY - United Kingdom
PB - Taylor & Francis
SN - 0095-2990
SN - 1097-9891
AD - Greenfield, Lawrence, 11123 Midvale Rd., Kensington, MD, US, 20895
N1 - Accession Number: 2005-03578-004. PMID: 15540492 Partial author list: First Author & Affiliation: Greenfield, Lawrence; Caliber Associates, Fairfax, VA, US. Other Publishers: Informa Healthcare. Release Date: 20050425. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Long Term Care; Residential Care Institutions; Treatment Outcomes. Minor Descriptor: Drug Abuse; Human Females; Treatment Compliance. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2004.
AB - The effectiveness of residential substance abuse treatment for women was examined using data from the Center for Substance Abuse Treatment's Residential Women and Children/Pregnant and Postpartum Women (RWC/PPW) Cross-Site Study and two other recent national studies. Treatment success was defined as posttreatment abstinence from further drug or alcohol use, measured through in-person follow-up interviews conducted 6-12 months after each client's discharge. Despite differences in treatment programs, client profiles, follow-up intervals, data collection methods, and other factors, all three studies found high treatment success rates--ranging narrowly from 68% to 71% abstinent--among women who spent six months or more in treatment. Success rates were lower, and between-study differences were larger, for clients with shorter stays in treatment. Controlling for salient client and treatment project characteristics, strong associations between length of stay in treatment and posttreatment abstinence rate were found in all three studies, suggesting that women's length of stay in residential treatment is a major determinant of treatment effectiveness. In further analysis of RWC/PPW data, treatment completion was also found to be an important outcome factor. Among clients who remained in treatment for at least three months, those who achieved their treatment goals in three to five months abstinence outcomes were as good as those for clients who took more than six months to complete their treatment (76%-78% abstinent) and substantially better than those for clients who did not complete treatment (51%-52% abstinent). Notably, however, most of the RWC/PPW clients who successfully completed treatment (71%) required six months or more to do so. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - long term care
KW - residential substance abuse treatment
KW - human females
KW - treatment effectiveness
KW - alcohol use
KW - treatment compliance
KW - 2004
KW - Drug Rehabilitation
KW - Long Term Care
KW - Residential Care Institutions
KW - Treatment Outcomes
KW - Drug Abuse
KW - Human Females
KW - Treatment Compliance
KW - 2004
DO - 10.1081/ADA-200032290
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03578-004&site=ehost-live&scope=site
UR - lg439@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12354-004
AN - 2006-12354-004
AU - Kashon, Michael L.
AU - Ross, G. Webster
AU - O'Callaghan, James P.
AU - Miller, Diane B.
AU - Petrovitch, Helen
AU - Burchfiel, Cecil M.
AU - Sharp, Dan S.
AU - Markesbery, William R.
AU - Davis, Daron G.
AU - Hardman, John
AU - Nelson, James
AU - White, Lon R.
T1 - Associations of cortical astrogliosis with cognitive performance and dementia status.
JF - Journal of Alzheimer's Disease
JO - Journal of Alzheimer's Disease
JA - J Alzheimers Dis
Y1 - 2004///
VL - 6
IS - 6
SP - 595
EP - 604
CY - Netherlands
PB - IOS Press
SN - 1387-2877
SN - 1875-8908
AD - Kashon, Michael L., Centers for Disease Control and Prevention-NIOSH, Health Effect Laboratory Division, 1095 Willowdale Road, Morgantown, WV, US, 26505
N1 - Accession Number: 2006-12354-004. PMID: 15665400 Partial author list: First Author & Affiliation: Kashon, Michael L.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, US. Release Date: 20061127. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Dementia. Minor Descriptor: Autopsy; Brain; Frontal Lobe; Neuropathology; Proteins; Temporal Lobe. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2004.
AB - We examined 204 decedents of the autopsy component of the Honolulu-Asia Aging Study, a longitudinal cohort study, who had been clinically assessed for dementia. A sensitive ELISA technique was used to quantify glial fibrillary acidic protein (GFAP), a marker for astrogliosis, in four specific cortical brain regions and assess associations between GFAP and 1) a measure of cognitive function, 2) several clinical dementia conditions, and 3) neuritic plaque (NP) and neurofibrillary tangle (NFT) formation. Cognitive function was inversely associated with GFAP in the occipital, parietal and temporal lobes, but not in the frontal lobe. This relationship remained significant when the contribution of NP and NFT counts was removed. Further, compared to brain samples from non-demented individuals, significantly greater GFAP levels were found in samples from individuals diagnosed with Alzheimer's disease, mixed dementia, and vascular mediated dementia. Because elevated levels of GFAP reflect astroglial responses to even subtle forms of neural damage, our data indicate that increments in GFAP may provide independent, supporting evidence for the damage underlying dementia, even in the absence of other evidence of neuropathology such as the presence of NPs or NFTs. Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognitive function
KW - cortical astrogliosis
KW - dementia
KW - glial fibrillary acidic protein
KW - neuritic plaque
KW - neurofibrillary tangle
KW - autopsy
KW - 2004
KW - Cognitive Ability
KW - Dementia
KW - Autopsy
KW - Brain
KW - Frontal Lobe
KW - Neuropathology
KW - Proteins
KW - Temporal Lobe
KW - 2004
U1 - Sponsor: US Department of Army, Spark M. Matsunaga Veterans Affairs Medical Center, US. Grant: DAMD17-98-1-8621. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute on Aging, US. Grant: NO1-AG-4-2149; AG P50-05144. Recipients: No recipient indicated
U1 - Sponsor: National Heart, Lung, and Blood Institute, US. Grant: NO1-HC-05102. Recipients: No recipient indicated
U1 - Sponsor: National Institute for Occupational Safety and Health, US. Grant: HELDOOB0059. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12354-004&site=ehost-live&scope=site
UR - mkashon@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03575-008
AN - 2005-03575-008
AU - Epstein, Joan F.
AU - Hourani, Laurel L.
AU - Heller, David C.
T1 - Predictors of Treatment Receipt Among Adults with a Drug Use Disorder.
JF - The American Journal of Drug and Alcohol Abuse
JO - The American Journal of Drug and Alcohol Abuse
JA - Am J Drug Alcohol Abuse
Y1 - 2004///
VL - 30
IS - 4
SP - 841
EP - 869
CY - United Kingdom
PB - Taylor & Francis
SN - 0095-2990
SN - 1097-9891
AD - Epstein, Joan F., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US, 20857
N1 - Accession Number: 2005-03575-008. PMID: 15624552 Partial author list: First Author & Affiliation: Epstein, Joan F.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Informa Healthcare. Release Date: 20050425. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Drug Abuse; Drug Rehabilitation; Health Care Utilization; Psychosocial Factors. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 29. Issue Publication Date: 2004.
AB - This study used data from the 2000 and 2001 National Household Surveys on Drug Abuse to examine factors that contribute to the receipt of specialty substance abuse treatment, which is defined as treatment in rehabilitation facilities, hospitals, or mental health centers designed to help stop or reduce drug use. The population examined was a nationally representative sample of 3291 adults aged 18 or older with a drug use disorder in the past 12 months. Data were collected by computer-assisted interviews using a combination of computer-assisted personal interviews conducted by the interviewer and audio computer-assisted self-interviewing guided by the computer and respondent. Using descriptive analyses and multivariate logistic regression models, this study compared sociodemographic, substance abuse, and psychosocial characteristics of those receiving treatment with those not receiving treatment; it also examined the factors that influenced treatment receipt while controlling for potential confounders. Characteristics significantly contributing to treatment receipt among adults with a drug use disorder included the following: a woman without social support; a high school graduate with no college education; those receiving insurance through Medicaid or a state Children's Health Insurance Program; those on probation, parole, or supervised release in the past year; a daily smoker of cigarettes; those meeting at least three criteria for drug dependence; those having past year dependence on or abuse of alcohol; and those receiving any mental health treatment or counseling in the past year. Adults associated with the criminal justice system had a different pattern of treatment predictors from those who were not involved with the criminal justice system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment receipt
KW - drug use disorder
KW - substance abuse treatment
KW - drug rehabilitation
KW - sociodemographic characteristics
KW - psychosocial characteristics
KW - 2004
KW - Demographic Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Utilization
KW - Psychosocial Factors
KW - 2004
DO - 10.1081/ADA-200037550
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03575-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03315-027
AN - 2005-03315-027
AU - McHugo, Gregory J.
AU - Bebout, Richard R.
AU - Harris, Maxine
AU - Cleghorn, Stephen
AU - Herring, Gloria
AU - Xie, Haiyi
AU - Becker, Deborah
AU - Drake, Robert E.
T1 - A Randomized Controlled Trial of Integrated Versus Parallel Housing Services for Homeless Adults With Severe Mental Illness.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 2004///
VL - 30
IS - 4
SP - 969
EP - 982
CY - US
PB - National Institute of Mental Health
SN - 0586-7614
SN - 1745-1701
AD - McHugo, Gregory J., New Hampshire-Dartmouth Psychiatric Research Center, 2 Whipple Place, Suite 202, Lebanon, NH, US, 03766
N1 - Accession Number: 2005-03315-027. PMID: 15957201 Partial author list: First Author & Affiliation: McHugo, Gregory J.; Department of Community and Family Medicine, New Hampshire-Dartmouth Psychiatric Research Center, Dartmouth Medical School, Hanover, NH, US. Other Publishers: Oxford University Press. Release Date: 20050411. Correction Date: 20151123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Homeless; Housing; Mental Disorders; Mental Health Services. Minor Descriptor: Mental Health. Classification: Community & Social Services (3373); Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Personal History Form; Colorado Symptom Index; Structured Clinical Interview for DSM-IV Axis I Disorders; Conflict Tactics Scales DOI: 10.1037/t02125-000; Quality of Life Interview DOI: 10.1037/t02516-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2004.
AB - This study compared two contemporary approaches to linking housing and mental health services. In the integrated housing program, case management and housing services were provided by teams within a single agency and were closely coordinated. In the parallel housing condition, case management services were provided by mobile assertive community treatment teams and housing by routine community-based landlords. Adults with severe mental illness who were at high risk for homelessness (n = 121; 72.7% schizophrenia spectrum) were assigned randomly to integrated or parallel housing services and followed for 18 months. Integrated housing services led to more days of stable housing and greater life satisfaction than parallel housing services, especially for male participants. Integrated housing services were also associated with greater reductions in psychiatric symptoms. Closer integration between clinical and housing services, and greater use of supervised living settings, led to more time in stable housing for participants in the integrated housing services condition and was associated with greater gains in several outcome domains. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - controlled trial
KW - housing services
KW - integrated housing
KW - parallel housing
KW - mental health services
KW - homeless adults
KW - mental illness
KW - housing management services
KW - community treatment
KW - 2004
KW - Community Services
KW - Homeless
KW - Housing
KW - Mental Disorders
KW - Mental Health Services
KW - Mental Health
KW - 2004
DO - 10.1093/oxfordjournals.schbul.a007146
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03315-027&site=ehost-live&scope=site
UR - gregory.mchugo@dartmouth.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CONF
ID - 2005-01253-000
AN - 2005-01253-000
AU - Ali, Syed F.
AU - Nabeshima, Toshitaka
AU - Yanagita, Tomoji
ED - Ali, Syed F.
ED - Nabeshima, Toshitaka
ED - Yanagita, Tomoji
T1 - Current status of drug dependence/abuse studies: Cellular and molecular mechanisms of drugs of abuse and neurotoxicity.
T3 - Annals of the New York Academy of Sciences; Vol 1025
Y1 - 2004///
VL - 1025
CY - New York, NY, US
PB - New York Academy of Sciences
SN - 1-57331-522-2
SN - 1-57331-523-0
AD - Ali, Syed F., Neurochemistry Laboratory, Division of Neurotoxicity, National Center for Toxicological Research/FDA, Jefferson, AR, US, 72079
N1 - Accession Number: 2005-01253-000. Partial author list: First Author & Affiliation: Ali, Syed F.; Neurochemistry Laboratory, Division of Neurotoxicity, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20050425. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Conference Proceedings. ISBN: 1-57331-522-2, Hardcover; 1-57331-523-0, Paperback. Language: English. Conference Information: Current Status of Dependence/Abuse Studies: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity, Jul-Aug, 2003, Kyoto International Conference Hall, Kyoto, Japan. Conference Note: This volume is the result of the aforementioned meeting, a satellite meeting of the International Society for Neurochemistry Meeting and Japanese Forum on Nicotine and Drug Dependence Studies. Major Descriptor: Drug Abuse; Drugs; Neurobiology; Neurochemistry; Neurotoxicity. Minor Descriptor: Drug Dependency. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 642.
AB - This volume contains reviewed versions of papers that were presented at the satellite meeting of the International Society for Neurochemistry Meeting and Japanese Forum on Nicotine and Drug Dependence Studies, entitled 'Current Status of Dependence/Abuse Studies: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity.' The major goals of the conference were to understand the cellular and molecular mechanisms of drugs of abuse, such as cocaine, substituted amphetamines, heroin, opiates, morphine, marijuana, nicotine, GHB, and organic solvents, and to bring together clinical and basic scientists in a multinational, multidisciplinary forum to exchange ideas and data related to this expanding field of research. Separate sessions were devoted to the underlying mechanisms of drug addiction; role of sensitization in psychosis and its molecular mechanism; approaches to psychotherapy for drug dependence; neurodegeneration, neuroprotection in substituted amphetamine-induced neurotoxicity; biological markers and molecular mechanisms of methamphetamine psychosis; and specific neuronal markers and neurotoxicity of toluene, marijuana, alcohol, nicotine, and MDMA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug dependence
KW - drug abuse
KW - neurotoxicity
KW - cellular mechanisms
KW - molecular mechanisms
KW - 2004
KW - Drug Abuse
KW - Drugs
KW - Neurobiology
KW - Neurochemistry
KW - Neurotoxicity
KW - Drug Dependency
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01253-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106658176
T1 - Measuring the quality of children's health care: a prerequisite to action.
AU - Dougherty D
AU - Simpson LA
Y1 - 2004/01/02/Jan2004 Supplement
N1 - Accession Number: 106658176. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Jan2004 Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child Health Services
KW - Quality Improvement
KW - Quality of Health Care
KW - Child
KW - Child, Preschool
KW - Health Policy -- United States
KW - Infant
KW - Physicians
KW - United States
SP - 185
EP - 198
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To assess the availability and use of quality measures for children's health care, highlight promising developments, and develop recommendations for future action steps by the child health quality measurement and improvement fields, pediatrics, and the national quality of care enterprise generally. STUDY DESIGN: Two-day invitational expert meeting, informed by 3 commissioned articles. RESULTS: Quality of care for children is far less than optimal. A number of measures are available for measuring children's health care quality on a regular basis, although measures are scarce at least in many areas (eg, pediatric patient safety, end-of-life-care, mental health care, oral health care, neonatal care, care for school-aged children, and coordination of care). Many of the available measures are not being applied regularly to measure the quality of children's health care; barriers to implementation include lack of an information infrastructure that is child- and quality-friendly and lack of public support for improving children's health care quality. To improve the availability and use of quality measures for accountability and improvement, meeting participants recommended that at least 4 activities be national priorities: 1) build public support for quality measurement and improvement in children's health care; 2) create the information technology infrastructure that can facilitate collection and use of data; 3) improve the reliability, validity, and feasibility of existing measures; and 4) create the evidence base for measures development and quality improvement. CONCLUSIONS: Although substantial progress has been made in the development of quality measures and the implementation of quality-improvement strategies for children's health care, interest in quality of care for children lags behind that for adult conditions and disorders. Making significant progress will require not only sustained attention by those concerned about improving children's health and health care but also activities to build a broad base of support among the public and key health care decision-makers.
SN - 0031-4005
AD - Child Health Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; ddougher@ahrq.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106658176&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jacobson-Kram, David
AU - Sistare, Frank D.
AU - Jacobs, Abigail C.
T1 - Use of Transgenic Mice in Carcinogenicity Hazard Assessment.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01/02/Jan2004 Supplement
VL - 32
IS - 1S
M3 - Article
SP - 49
EP - 52
SN - 01926233
AB - Determining the carcinogenic potential of materials to which humans have significant exposure is an important, complex and imperfect exercise. Not only are the methods for such determinations protracted, expensive and utilize large numbers of animals, extrapolation of data from such studies to human risk is imprecise. Toxicologists have long recognized these shortcomings but the 2-year chronic rodent study has remained the gold standard. Recent developments in the field of molecular oncology and development of methods to insert or inactivate specific genes in animals have provided the tools with which to develop the next generation of carcinogenicity assays. With improved understanding of oncogene activation and tumor suppressor gene inactivation a number of animal models have been developed to dramatically reduce latency for chemically induced cancers. This has led to the development of shorter carcinogenicity assays. Also, because the spontaneous tumor frequencies in these animals are low during the in-life portion of the study, and studies are terminated well before the health complications of advanced aging are observed, it has been possible to reduce the group sizes and reduce animal usage. FDA's adoption of ICH S1B in 1997, (ICH, 1997) “Testing for the Carcinogenicity of Pharmaceuticals,” opened the door for the use of such transgenic models in regulatory toxicology. This presentation reviews the current state of the science and its application to regulatory issues. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity testing
KW - p53
KW - regulatory toxicology
KW - Tg.AC
KW - TgrasH2
KW - transgenic mice
N1 - Accession Number: 54381072; Jacobson-Kram, David 1; Sistare, Frank D. 2; Jacobs, Abigail C. 2; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20850, USA, jacobsonkram@cder.fda.gov; 2: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20850, USA; Issue Info: Jan2004 Supplement, Vol. 32 Issue 1S, p49; Author-Supplied Keyword: Carcinogenicity testing; Author-Supplied Keyword: p53; Author-Supplied Keyword: regulatory toxicology; Author-Supplied Keyword: Tg.AC; Author-Supplied Keyword: TgrasH2; Author-Supplied Keyword: transgenic mice; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 3464
L3 - 10.1080/01926230490424761
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=54381072&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gillespie, John W.
AU - Gannot, Gallya
AU - Tangrea, Michael A.
AU - Ahram, Mamoun
AU - Best, Carolyn J.M.
AU - Bichsel, Verena E.
AU - Petricoin, Emmanuel F.
AU - Emmert-Buck, Michael R.
AU - Chuaqui, Rodrigo F.
T1 - Molecular Profiling of Cancer.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01/02/Jan2004 Supplement
VL - 32
IS - 1S
M3 - Article
SP - 67
EP - 71
SN - 01926233
AB - The objective of molecular profiling of cancer is to determine the differential expression of genes and proteins from human tissue in the progression from normal precursor tissue to preneoplastic tissue to cancer in order to discover diagnostic, prognostic, and therapeutic markers. With the development of high-throughput analytical techniques such as microarrays and 2-D PAGE as well as the development of tools for cell procurement from histological sections such as laser capture microdissection (LCM), it is now possible to perform molecular analyses on specific cell populations from tissue. Since recognition of specific cell populations is critical, there is a need to optimize fixation and embedding not only to improve preservation of biomolecules, but also to maintain excellent histology. We have shown that 70% ethanol fixation of prostate tissue improves the recovery of DNA, RNA, and proteins over routine formalin fixation and maintains histological quality comparable to formalin. There is also a need to develop new technologies in order to expand the range of tissue types that can be analyzed. The development and applications of Layered Expression Scanning (LES) for the molecular analysis of whole tissue sections are discussed. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - cancer
KW - expression
KW - gene
KW - microdissection
KW - Molecular
KW - profiling
KW - protein
N1 - Accession Number: 54381084; Gillespie, John W. 1; Gannot, Gallya 2; Tangrea, Michael A. 2; Ahram, Mamoun 3; Best, Carolyn J.M. 2; Bichsel, Verena E. 4; Petricoin, Emmanuel F. 5; Emmert-Buck, Michael R. 2; Chuaqui, Rodrigo F. 2; Affiliations: 1: Science Applications International Corporation, National Cancer Institute, Bethesda, Maryland, USA, jgill@mail.nih.gov; 2: Pathogenetics Unit, National Cancer Institute, Bethesda, Maryland, USA; 3: Battelle, Pacific Northwest National Laboratory, Richland, Washington, USA; 4: Federal Institute of Intellectual Property, Bern, Switzerland; 5: Center for Biologics and Research, Food and Drug Administration, Bethesda, Maryland, USA; Issue Info: Jan2004 Supplement, Vol. 32 Issue 1S, p67; Author-Supplied Keyword: cancer; Author-Supplied Keyword: expression; Author-Supplied Keyword: gene; Author-Supplied Keyword: microdissection; Author-Supplied Keyword: Molecular; Author-Supplied Keyword: profiling; Author-Supplied Keyword: protein; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 3387
L3 - 10.1080/01926230490430728
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=54381084&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Macgregor, James T.
T1 - Biomarkers of Cancer Risk and Therapeutic Benefit: New Technologies, New Opportunities, and Some Challenges.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01/02/Jan2004 Supplement
VL - 32
IS - 1S
M3 - Article
SP - 99
EP - 105
SN - 01926233
AB - The biotechnology revolution offers unprecedented opportunities for identification of mechanistically-based biomarkers that report and predict cancer and other pathologies. The combination of genomic technologies with a knowledge of gene sequence and sequence conservation has made available markers that facilitate the correlation of genetic variation with biological outcomes, and “-omic” technologies allow efficient biochemical characterization of functional pathways—providing new markers of the susceptibility of individuals to cancer development, and of tumor susceptibility to specific therapies. New therapeutic agents targeted to individuals with specific genetic or biochemical characteristics already exist. The powerful -omic technologies allow efficient monitoring of gene transcripts, proteins, and intermediary metabolites, making it possible to monitor a large number of key cellular pathways simultaneously. This has enabled the identification of key biomarkers and signaling molecules associated with cell growth, cell death, and cellular metabolism. These new markers are facilitating monitoring of functional disturbance, molecular and cellular damage, and damage-response. Improved imaging technologies have made it feasible to image some of these molecular events noninvasively. To meet the challenge of evaluating and developing consensus criteria for the application of these new technologies and biomarkers, consortium approaches are being increasingly undertaken to share resources and to build a common understanding among the research, industry, and regulatory communities. These developments promise more efficient pharmaceutical product development, safer and more efficacious drugs, and provide clinical practitioners with new and better biomarkers for cancer screening, patient monitoring, and choice of therapy. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biomarkers
KW - cancer
KW - efficacy
KW - polymorphism
KW - susceptibility
KW - toxicity
N1 - Accession Number: 54381081; Macgregor, James T. 1; Affiliations: 1: FDA National Center for Toxicological Research, Rockville, Maryland, USA, jmacgregor@nctr.fda.gov; Issue Info: Jan2004 Supplement, Vol. 32 Issue 1S, p99; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: cancer; Author-Supplied Keyword: efficacy; Author-Supplied Keyword: polymorphism; Author-Supplied Keyword: susceptibility; Author-Supplied Keyword: toxicity; Number of Pages: 7p; Document Type: Article; Full Text Word Count: 6529
L3 - 10.1080/01926230490425067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=54381081&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Petricoin, Emanuel F.
AU - Rajapaske, Vinodh
AU - Herman, Eugene H.
AU - Arekani, Ali M.
AU - Ross, Sally
AU - Johann, Donald
AU - Knapton, Alan
AU - Zhang, J.
AU - Hitt, Ben A.
AU - Conrads, Thomas P.
AU - Veenstra, Timothy D.
AU - Liotta, Lance A.
AU - Sistare, Frank D.
T1 - Toxicoproteomics: Serum Proteomic Pattern Diagnostics for Early Detection of Drug Induced Cardiac Toxicities and Cardioprotection.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/01/02/Jan2004 Supplement
VL - 32
IS - 1S
M3 - Article
SP - 122
EP - 130
SN - 01926233
AB - Proteomics is more than just generating lists of proteins that increase or decrease in expression as a cause or consequence of pathology. The goal should be to characterize the information flow through the intercellular protein circuitry which communicates with the extracellular microenvironment and then ultimately to the serum/plasma macroenvironment. The nature of this information can be a cause, or a consequence, of disease and toxicity based processes as cascades of reinforcing information percolate through the system and become reflected in changing proteomic information content of the circulation. Serum Proteomic Pattern Diagnostics is a new type of proteomic platform in which patterns of proteomic signatures from high dimensional mass spectrometry data are used as a diagnostic classifier. While this approach has shown tremendous promise in early detection of cancers, detection of drug-induced toxicity may also be possible with this same technology. Analysis of serum from rat models of anthracycline and anthracenedione induced cardiotoxicity indicate the potential clinical utility of diagnostic proteomic patterns where low molecular weight peptides and protein fragments may have higher accuracy than traditional biomarkers of cardiotoxicity such as troponins. These fragments may one day be harvested by circulating nanoparticles designed to absorb, enrich and amplify the diagnostic biomarker repertoire generated even at the critical initial stages of toxicity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - cardiotoxicity
KW - Mass spectrometry
KW - nanotechnology
KW - patterns
KW - proteomics
KW - toxicoproteomics
N1 - Accession Number: 54381083; Petricoin, Emanuel F. 1; Rajapaske, Vinodh 2; Herman, Eugene H. 3; Arekani, Ali M. 4; Ross, Sally 2; Johann, Donald 2; Knapton, Alan 3; Zhang, J. 3; Hitt, Ben A. 5; Conrads, Thomas P. 6; Veenstra, Timothy D. 6; Liotta, Lance A. 2; Sistare, Frank D. 3; Affiliations: 1: FDA-NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA, petricoin@cber.fda.gov; 2: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA; 3: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, USA; 4: FDA-NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA; 5: Correlogic Systems, Inc., Bethesda, Maryland, USA; 6: NCI Biomedical Proteomics Program, Analytical Chemistry Laboratory, Mass Spectrometry Center, SAIC Frederick, Inc., SAIC-NCI, Frederick, Maryland, USA; Issue Info: Jan2004 Supplement, Vol. 32 Issue 1S, p122; Author-Supplied Keyword: cardiotoxicity; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: patterns; Author-Supplied Keyword: proteomics; Author-Supplied Keyword: toxicoproteomics; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 6023
L3 - 10.1080/01926230490426516
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ER -
TY - JOUR
AU - Kao, George
AU - Tsai, Chao-Ming
T1 - Quantification of O-acetyl, N-acetyl and phosphate groups and determination of the extent of O-acetylation in bacterial vaccine polysaccharides by high-performance anion-exchange chromatography with conductivity detection (HPAEC-CD)
JO - Vaccine
JF - Vaccine
Y1 - 2004/01/02/
VL - 22
IS - 3/4
M3 - Article
SP - 335
SN - 0264410X
AB - The O-acetyl groups in meningococcal A and typhoid Vi polysaccharides (PSs) are functional immunogenic epitopes in humans. To quantify and determine the extent of O-acetylation in these and other bacterial vaccine PSs, anion-exchange HPLC methods have been developed for quantification of O-acetyl, N-acetyl, and phosphate groups in the PSs after these groups were hydrolyzed into anions. The O-acetylation in meningococcal A, C, Y and W-135, pneumococcal 9V and 18C and typhoid Vi PSs were analyzed. The O-acetyl group was selectively released from a PS as acetate by mild alkaline hydrolysis in 10 or 20 mM NaOH at 37 °C until maximum release. The acetate in the hydrolysate was then quantified by high-performance anion-exchange chromatography with conductivity detection (HPAEC-CD) after removal of the PS by filtration with a 10,000 molecular-weight-cut-off membrane. Since the extent of O-acetylation on the PSs depends on bacterial species, strains and growth conditions, the N-acetyl group of amino-sugars, phosphate or monosaccharide components of the PSs were also quantified using HPAEC with conductivity or amperometry detection to determine the molar ratios of the O-acetyl group to these components. The average numbers of O-acetyl molecules in one PS repeating unit of the PSs were obtained from the molar ratios. Besides the O-acetyl determination, the pyruvate component in non-O-acetylated pneumococcal type 4 PS was analyzed by the HPAEC method. The HPAEC method can quantify the O-acetyl content in 0.2 μg of the meningococcal C PS and has a sensitivity at least 10 times higher than that of the colorimetric Hestrin assay. The method can be used for routine analysis of O-acetylation of PSs for quality control of vaccine PSs. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CEREBROSPINAL meningitis
KW - TYPHOID fever
KW - POLYSACCHARIDES
KW - ACETYLATION
KW - Bacterial polysaccharides
KW - HPLC-conductivity detection
KW - O-acetylation
N1 - Accession Number: 11606344; Kao, George 1 Tsai, Chao-Ming; Email Address: tsai@cber.fda.gov; Affiliation: 1: Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike HFM-428, Rockville, MD 20852, USA; Source Info: Jan2004, Vol. 22 Issue 3/4, p335; Subject Term: CEREBROSPINAL meningitis; Subject Term: TYPHOID fever; Subject Term: POLYSACCHARIDES; Subject Term: ACETYLATION; Author-Supplied Keyword: Bacterial polysaccharides; Author-Supplied Keyword: HPLC-conductivity detection; Author-Supplied Keyword: O-acetylation; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.08.008
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ER -
TY - JOUR
AU - Meseda, Clement A.
AU - Schmeisser, Falko
AU - Pedersen, Robin
AU - Woerner, Amy
AU - Weir, Jerry P.
T1 - DNA immunization with a herpes simplex virus 2 bacterial artificial chromosome
JO - Virology
JF - Virology
Y1 - 2004/01/05/
VL - 318
IS - 1
M3 - Article
SP - 420
SN - 00426822
AB - Construction of a herpes simplex virus 2 (HSV-2) bacterial artificial chromosome (BAC) is described. BAC vector sequences were inserted into the thymidine kinase gene of HSV-2 by homologous recombination. DNA from cells infected with the resulting recombinant virus was transformed into E. coli, and colonies containing the HSV-2 BAC (HSV2-BAC) were isolated and analyzed for the expected genotype. HSV2-BAC DNA was infectious when transfected back into mammalian cells and the resulting virus was thymidine kinase negative. When used to immunize mice, the HSV2-BAC DNA elicited a strong HSV-2 specific antibody response that was equal to or greater than live virus immunization. Further, HSV2-BAC immunization was protective when animals were challenged with a lethal dose of virus. The utility of the HSV2-BAC for construction of recombinant virus genomes was demonstrated by elimination of the HSV-2 glycoprotein D (gD) gene. A recombinant HSV-2 BAC with the gD gene deleted was isolated and shown to be incapable of producing infectious virus following transfection unless an HSV gD gene was expressed in a complementing cell line. Immunization of mice with the HSV2 gD-BAC also elicited an HSV-2 specific antibody response and was protective. The results demonstrate the feasibility of DNA immunization with HSV-2 bacterial artificial chromosomes for replicating and nonreplicating candidate HSV-2 vaccines, as well as the utility of BAC technology for construction and maintenance of novel HSV-2 vaccines. The results further suggest that such technology will be a powerful tool for dissecting the immune response to HSV-2. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - THYMIDINE
KW - FOCAL adhesion kinase
KW - BAC
KW - Herpes simplex virus 2
KW - Thymidine kinase
N1 - Accession Number: 12238854; Meseda, Clement A. 1 Schmeisser, Falko 1 Pedersen, Robin 1 Woerner, Amy 1 Weir, Jerry P.; Email Address: weirj@cber.fda.gov; Affiliation: 1: Laboratory of DNA Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jan2004, Vol. 318 Issue 1, p420; Subject Term: HERPES simplex virus; Subject Term: THYMIDINE; Subject Term: FOCAL adhesion kinase; Author-Supplied Keyword: BAC; Author-Supplied Keyword: Herpes simplex virus 2; Author-Supplied Keyword: Thymidine kinase; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2003.09.033
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ER -
TY - JOUR
AU - Maynard, Andrew D.
AU - Baron, Paul A.
AU - Foley, Michael
AU - Shvedova, Anna A.
AU - Kisin, Elena R.
AU - Castranova, Vincent
T1 - Exposure to Carbon Nanotube Material: Aerosol Release During the Handling of Unrefined Single-Walled Carbon Nanotube Material.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/01/09/
VL - 67
IS - 1
M3 - Article
SP - 87
EP - 107
SN - 15287394
AB - Carbon nanotubes represent a relatively recently discovered allotrope of carbon that exhibits unique properties. While commercial interest in the material is leading to the development of mass production and handling facilities, little is known of the risk associated with exposure. In a two-part study, preliminary investigations have been carried out into the potential exposure routes and toxicity of single-walled carbon nanotube material (SWCNT)--a specific form of the allotrope. The material is characterized by bundles of fibrous carbon molecules that may be a few nanometers in diameter, but micrometers in length. The two production processes investigated use-transition metal catalysts, leading to the inclusion of nanometer-scale metallic particles within unrefined SWCNT material. A laboratory-based study was undertaken to evaluate the physical nature of the aerosol formed from SWCNT during mechanical agitation. This was complemented by a field study in which airborne and dermal exposure to SWCNT was investigated while handling unrefined material. Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low. Estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53 μg/m 3 in all cases. Glove deposits of SWCNT during handling were estimated at between 0.2 mg and 6 mg per hand. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - NANOTUBES
KW - CARBON
KW - AIR pollution
KW - POLLUTION
KW - ENVIRONMENTAL health
N1 - Accession Number: 11692422; Maynard, Andrew D. 1; Email Address: amaynard@cdc.gov Baron, Paul A. 1 Foley, Michael 2 Shvedova, Anna A. 3 Kisin, Elena R. 4 Castranova, Vincent 3; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA 2: Comprehensive Health Services, Inc., NASA-JSC, Houston, Texas, Ohio 3: Pathology and Physiology Research Branch, HELD, NOSH, and Physiology and Pharmacology Department, West Virginia University, Morgantown, West Virginia, USA 4: Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, West Virginia, USA; Source Info: 2004, Vol. 67 Issue 1, p87; Subject Term: AEROSOLS (Sprays); Subject Term: NANOTUBES; Subject Term: CARBON; Subject Term: AIR pollution; Subject Term: POLLUTION; Subject Term: ENVIRONMENTAL health; Number of Pages: 21p; Document Type: Article
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ER -
TY - JOUR
AU - Yan, Jian
AU - Wang, Lei
AU - Fu, Peter P.
AU - Yu, Hongtao
T1 - Photomutagenicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2004/01/10/
VL - 557
IS - 1
M3 - Article
SP - 99
SN - 13835718
AB - The photomutagenicity of 16 polycyclic aromatic hydrocarbons (PAHs), all on the United States Environmental Protection Agency (US EPA) priority pollutant list, was studied. Concomitant exposing the Salmonella typhimurium bacteria strain TA102 to one of the PAHs and light (1.1 J/cm2 UVA+2.1 J/cm2 visible) without the activation enzyme S9, strong photomutagenic response is observed for anthracene, benz[a]anthracene, benzo[ghi]perylene, benzo[a]pyrene, indeno[1,2,3-cd]pyrene, and pyrene. Under the same conditions, acenaphthene, acenaphthylene, benzo[k]fluoranthene, chrysene, and fluorene are weakly photomutagenic. Benzo[b]fluoranthene, fluoranthene, naphthalene, phenanthrene, and dibenz[a,h]anthracene are not photomutagenic. These results indicate that PAHs can be activated by light and become mutagenic in Salmonella TA102 bacteria. At the same time, the mutagenicity for all the 16 PAHs was examined with the standard mutagenicity test with 10% S9 as the activation system. Benzo[b]fluoranthene, benzo[k]fluoranthene, chrysene, acenaphthylene, and fluorene are weakly mutagenic, while the rest of the PAHs are not. In general, the photomutagenicity of PAHs in TA102 does not correlate with their S9-activated mutagenicity in either TA102 or TA98/TA100 since they involve different activation mechanisms. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hydrocarbons
KW - Aromatic compounds
KW - Pollutants
KW - United States
KW - 280–320 nm (UVB)
KW - 320–400 nm (UVA)
KW - 8-methoxypsoralen (8-MOP)
KW - Light irradiation
KW - Photomutagenicity
KW - Polycyclic aromatic hydrocarbons
KW - polycyclic aromatic hydrocarbons (PAHs)
KW - Salmonella typhimurium TA102 and TA98
KW - United States Environmental Protection Agency (US EPA)
N1 - Accession Number: 11826469; Yan, Jian 1; Wang, Lei 1; Fu, Peter P. 2; Yu, Hongtao 1; Email Address: yu@ccaix.jsums.edu; Affiliations: 1: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA; 2: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Jan2004, Vol. 557 Issue 1, p99; Thesaurus Term: Hydrocarbons; Thesaurus Term: Aromatic compounds; Thesaurus Term: Pollutants; Subject: United States; Author-Supplied Keyword: 280–320 nm (UVB); Author-Supplied Keyword: 320–400 nm (UVA); Author-Supplied Keyword: 8-methoxypsoralen (8-MOP); Author-Supplied Keyword: Light irradiation; Author-Supplied Keyword: Photomutagenicity; Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; Author-Supplied Keyword: polycyclic aromatic hydrocarbons (PAHs); Author-Supplied Keyword: Salmonella typhimurium TA102 and TA98; Author-Supplied Keyword: United States Environmental Protection Agency (US EPA); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mrgentox.2003.10.004
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ER -
TY - JOUR
AU - Kang, Il-Hyun
AU - Kim, Hyun-Jung
AU - Oh, Hyeyoung
AU - Park, Young In
AU - Dong, Mi-Sook
T1 - Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/01/12/
VL - 545
IS - 1/2
M3 - Article
SP - 37
SN - 00275107
AB - Heterocyclic amines (HCAs) produced by cooking meat products at high temperatures are promutagens that are activated by cytochrome P450 (CYP) lA2. Using a newly developed Salmonella typhimurium TA1538/1A2bc-b5 strain, we tested the effect of quercetin and naringenin on the mutagenicity of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). TA1538/1A2bc-b5 bears two plasmids, one expressing human CYP1A2 and NADPH-P450 reductase (NPR), and the other plasmid which expresses human cytochrome b5 (cyp b5). TA1538/1A2bc-b5 cells showed high activities of 7-ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase (MROD) associated with CYP1A2 and are very sensitive to mutagenesis induced by several HCAs. MeIQ was found to be the strongest mutagen among the HCAs tested in this system. Mutagenicity of MeIQ was enhanced 50 and 42% by quercetin at 0.1 and 1 μM, respectively, but suppressed 82 and 96% at 50 and 100 μM. Naringenin also increased the MeIQ-induced mutation about 37 and 22% at 0.1 and 1 μM, but suppressed it 32 and 63% at 50 and 100 μM concentrations, respectively, in TA 1538/1A2bc-b5 cells. Thus, they stimulated the MeIQ induced mutation at low concentrations, but strongly suppressed it at high concentrations. This biphasic effect of flavonoids was due to the stimulation or the inhibition of CYP1A2 activity in a dose-dependent manner judging by the activities of EROD or MROD in the Salmonella cells. These results indicate that quercetin and naringenin can exhibit inhibitory or stimulating effects on CYP1A2 mediated mutagenesis by MeIQ, depending on their concentrations. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HETEROCYCLIC compounds
KW - AMINES
KW - QUERCETIN
KW - MUTAGENS
KW - 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ)
KW - Cytochrome b5
KW - Human cytochrome P450
KW - NADPH-cytochrome P450 reductase
KW - Naringenin
KW - Quercetin
KW - Salmonella typhimurium TA1538
N1 - Accession Number: 11732501; Kang, Il-Hyun 1,2 Kim, Hyun-Jung 1 Oh, Hyeyoung 2 Park, Young In 1 Dong, Mi-Sook 1; Email Address: msdong@korea.ac.kr; Affiliation: 1: School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea 2: Korea Food and Drug Administration, Seoul, South Korea; Source Info: Jan2004, Vol. 545 Issue 1/2, p37; Subject Term: HETEROCYCLIC compounds; Subject Term: AMINES; Subject Term: QUERCETIN; Subject Term: MUTAGENS; Author-Supplied Keyword: 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ); Author-Supplied Keyword: Cytochrome b5; Author-Supplied Keyword: Human cytochrome P450; Author-Supplied Keyword: NADPH-cytochrome P450 reductase; Author-Supplied Keyword: Naringenin; Author-Supplied Keyword: Quercetin; Author-Supplied Keyword: Salmonella typhimurium TA1538; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.08.002
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ER -
TY - JOUR
AU - Surks, Martin I.
AU - Ortiz, Eduardo
AU - Daniels, Gilbert H.
AU - Sawin, Clark T.
AU - Col, Nananda F.
AU - Cobin, Rhoda H.
AU - Franklyn, Jayne A.
AU - Hershman, Jerome M.
AU - Burman, Kenneth D.
AU - Denke, Margo A.
AU - Gorman, Colum
AU - Cooper, Richard S.
AU - Weissman, Neil J.
T1 - Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/01/14/
VL - 291
IS - 2
M3 - Article
SP - 228
EP - 238
SN - 00987484
AB - Context: Patients with serum thyroid-stimulating hormone (TSH) levels outside the reference range and levels of free thyroxine (FT[sub 4]) and triiodothyronine (T[sub 3]) within the reference range are common in clinical practice. The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established. Objectives: To define subclinical thyroid disease, review its epidemiology, recommend an appropriate evaluation, explore the risks and benefits of treatment and consequences of nontreatment, and determine whether population-based screening is warranted. Data Sources: MEDLINE, EMBASE, Biosis, the Agency for Healthcare Research and Quality, National Guideline Clearing House, the Cochrane Database of Systematic Reviews and Controlled Trials Register, and several National Health Services (UK) databases were searched for articles on subclinical thyroid disease published between 1995 and 2002. Articles published before 1995 were recommended by expert consultants. Study Selection and Data Extraction: A total of 195 English-language or translated papers were reviewed. Editorials, individual case studies, studies enrolling fewer than 10 patients, and nonsystematic reviews were excluded. Information related to authorship, year of publication, number of subjects, study design, and results were extracted and formed the basis for an evidence report, consisting of tables and summaries of each subject area. Data Synthesis: The strength of the evidence that untreated subclinical thyroid disease is associated with clinical symptoms and adverse clinical outcomes was assessed and recommendations for clinical practice developed. Data relating the progression of subclinical to overt hypothyroidism were rated as good, but data relating treatment to prevention of progression were inadequate to determine a treatment benefit. Data relating a serum TSH level higher than 10 mIU/L to elevations in serum cholesterol were rated as fair but data r... [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROID diseases
KW - THYROXINE
KW - TRIIODOTHYRONINE
KW - EPIDEMIOLOGY
KW - HYPERTHYROIDISM
KW - Hyperthyroidism
KW - Hypothyroidism
KW - SCIENTIFIC REVIEW AND CLINICAL APPLICATIONS (Levinson W, ed)
KW - Thyroid-Stimulating Hormone
KW - Thyrotropin
N1 - Accession Number: 11942016; Surks, Martin I. 1 Ortiz, Eduardo 1 Daniels, Gilbert H. 1 Sawin, Clark T. 1 Col, Nananda F. 1 Cobin, Rhoda H. 1 Franklyn, Jayne A. 1 Hershman, Jerome M. 1 Burman, Kenneth D. 1 Denke, Margo A. 1 Gorman, Colum 1 Cooper, Richard S. 1 Weissman, Neil J. 1; Affiliation: 1: Departments of Medicine and Pathology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY (Dr Surks); Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Md (Dr Ortiz); Thyroid Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (Dr Daniels); Veterans Administration, Washington, DC (Dr Sawin); Harvard Medical School, Brigham and Women's Hospital, Division of Women's Health and Department of Medicine, Boston (Dr Col); Department of Medicine, Mount Sinai School of Medicine, New York, NY (Dr Cobin); Division of Medical Sciences, University of Birmingham, Birmingham, England (Dr Franklyn); Endocrinology and Diabetes Division, West Los Angeles VA Medical Center, University of California at Los Angeles School of Medicine (Dr Hershman); Endocrine Section, Washington Hospital Center, Washington, DC (Dr Burman); Department of Medicine, University of Texas Southwestern Medical Center at Dallas (Dr Denke); Research Development, Mayo Foundation, Rochester, Minn (Dr Gorman); Epidemiology, Loyola University Medical School, Chicago, Ill (Dr Cooper); and Cardiac Ultrasound, Washington Hospital Center, and Department of Medicine, Georgetown University Medical College, Washington, DC (Dr Weissman). Dr Denke is now with the University of Texas, San Antonio.; Source Info: 1/14/2004, Vol. 291 Issue 2, p228; Subject Term: THYROID diseases; Subject Term: THYROXINE; Subject Term: TRIIODOTHYRONINE; Subject Term: EPIDEMIOLOGY; Subject Term: HYPERTHYROIDISM; Author-Supplied Keyword: Hyperthyroidism; Author-Supplied Keyword: Hypothyroidism; Author-Supplied Keyword: SCIENTIFIC REVIEW AND CLINICAL APPLICATIONS (Levinson W, ed); Author-Supplied Keyword: Thyroid-Stimulating Hormone; Author-Supplied Keyword: Thyrotropin; Number of Pages: 11p; Document Type: Article
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ER -
TY - JOUR
AU - Sapsford, Kim E.
AU - Rasooly, Avraham
AU - Taitt, Chris R.
AU - Ligler, Frances S.
T1 - Detection of Campylobacter and Shigella Species in Food Samples Using an Array Biosensor.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2004/01/15/
VL - 76
IS - 2
M3 - Article
SP - 433
EP - 440
SN - 00032700
AB - Campylobacter and Shigella bacteria are common causes of food- and water-borne illness worldwide. There is a current need in food, medical, environmental, and military markets for a rapid and user-friendly method of detecting such pathogens. The array biosensor developed at the NIRL encompasses these qualities. In this study, 25-mm, sandwich immunoassays were developed for the detection of Campylobacter and Shigella species in both buffer and a variety of food and beverage samples. The limit of detection for Shigella dysenteriae in buffer and chicken carcass wash was 4.9 × 10[SUP4] mL[SUP-1], whereas Campylobacter jejuni could be measured at concentrations as low as 9.7 × 10[SUP2] cfu mL[SUP-1]. The limits of detection and dynamic range were found to vary depending on the sample matrix, but could be improved by running the sample over the waveguide surface for longer periods of time. Samples were run with no preconcentration or enrichment steps and little-to-no sample pretreatment prior to analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WATERBORNE infection
KW - CAMPYLOBACTER
KW - SHIGELLA
KW - PATHOGENIC microorganisms
KW - IMMUNOASSAY
KW - ANTIGENS
N1 - Accession Number: 12198480; Sapsford, Kim E. 1 Rasooly, Avraham 2 Taitt, Chris R. 3 Ligler, Frances S. 3; Email Address: fligler@cbmse.nrl.navy.mil.; Affiliation: 1: George Mason University, 10910 University Boulevard, MS 4E3, Manassas, Virginia 20110. 2: United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740. 3: Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Washington, DC 20375.; Source Info: 1/15/2004, Vol. 76 Issue 2, p433; Subject Term: WATERBORNE infection; Subject Term: CAMPYLOBACTER; Subject Term: SHIGELLA; Subject Term: PATHOGENIC microorganisms; Subject Term: IMMUNOASSAY; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Powers, John H.
AU - Albrecht, Renata
T1 - Lipid Amphotericin B Formulations as Comparators in Clinical Trials.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/01/15/
VL - 38
IS - 2
M3 - Letter
SP - 305
EP - 306
SN - 10584838
AB - Comments on the use of lipid amphotericin B formulations as comparators in clinical trials. Differences of individual lipid formulations of amphotericin B (LFAB) in pharmacokinetics and safety profiles; Potential safety benefit of LFAB; Questions on the consideration of LFAB as a gold standard.
KW - Amphotericin B
KW - Clinical trials
KW - Pharmacokinetics
KW - Drugs -- Effectiveness
N1 - Accession Number: 12083605; Powers, John H. 1; Email Address: POWERSJOH@cder.fda.gov; Albrecht, Renata 2; Affiliations: 1: Office of Drug Evaluation IV, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland; 2: Division of Special Pathogen and Immunological Drug Products, Center for Drug Evaluation and Research , US Food and Drug Administration, Rockville, Maryland; Issue Info: 1/15/2004, Vol. 38 Issue 2, p305; Subject Term: Amphotericin B; Subject Term: Clinical trials; Subject Term: Pharmacokinetics; Subject Term: Drugs -- Effectiveness; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hong Ge, Alan
AU - Chuang, Yao-Yu Eric
AU - Shuping Zhao, Yao-Yu Eric
AU - Min Tong, Yao-Yu Eric
AU - Mong-Hsun Tsai, Yao-Yu Eric
AU - Temenak, Joseph J.
AU - Richards, Allen L.
AU - Wei-Mei Ching, Allen L.
T1 - Comparative Genomics of Rickettsia prowazekii Madrid E and Breinl Strains.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2004/01/15/
VL - 186
IS - 2
M3 - Article
SP - 556
EP - 565
SN - 00219193
AB - Rickettsia prowazekii, the causative agent of epidemic typhus, has been responsible for millions of human deaths. Madrid E is an attenuated strain of R. prowazekii, while Breinl is a virulent strain. The genomic DNA sequence of Madrid E has recently been published. To study the genomic variations between Madrid E (reference) and Breinl (test) DNAs, cohybridization experiments were performed on a DNA microarray containing all 834 protein-coding genes of Madrid E. Of the 834 genes assessed, 24 genes showed 1.5- to 2.0-fold increases in hybridization signals in Breinl DNA compared to Madrid E DNA, indicating the presence of genomic variations in ∼3% of the total genes. Eighteen of these 24 genes are predicted to be involved in different functions. Southern blot analysis of five genes, virB4, ftsK, rfbE, lpxA, and rpoH, suggested the presence of an additional paralog(s) in Breinl, which might be related to the observed increase in hybridization signals. Studies by real-time reverse transcription-PCR revealed an increase in expression of the above-mentioned five genes and five other genes. In addition to the elevated hybridization signals of 24 genes observed in the Breinl strain, one gene (rp084) showed only 1/10 the hybridization signal of Madrid E. Further analysis of this gene by PCR and sequencing revealed a large deletion flanking the whole rp084 gene and part of the rp083 gene in the virulent Breinl strain. The results of this first rickettsial DNA microarray may provide some important information for the elucidation of pathogenic mechanisms of R. prowazekii. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAM-negative bacteria
KW - GENOMICS
KW - VIRULENCE (Microbiology)
KW - DNA microarrays
KW - HYBRIDIZATION
KW - GENES
N1 - Accession Number: 12256785; Hong Ge, Alan 1,2 Chuang, Yao-Yu Eric 3 Shuping Zhao, Yao-Yu Eric 3 Min Tong, Yao-Yu Eric 1,2 Mong-Hsun Tsai, Yao-Yu Eric 3 Temenak, Joseph J. 1,4 Richards, Allen L. 1 Wei-Mei Ching, Allen L. 1,2; Email Address: chingw@nmrc.navy.mil; Affiliation: 1: Rickettsial Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center 2: Department of Preventive Medicine and Biometrics, Uniformed Services University of The Health Sciences 3: Microarray Laboratory, Radiation Oncology Sciences Program, National Cancer Institute, National Institutes of Health 4: Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration; Source Info: Jan2004, Vol. 186 Issue 2, p556; Subject Term: GRAM-negative bacteria; Subject Term: GENOMICS; Subject Term: VIRULENCE (Microbiology); Subject Term: DNA microarrays; Subject Term: HYBRIDIZATION; Subject Term: GENES; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 5 Color Photographs, 10 Black and White Photographs, 2 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/JB.186.2.556-565.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wong-chew, Rosa María
AU - Islas-Romero, Rocío
AU - García-García, Maria De Lourdes
AU - Beeler, Judy A.
AU - Audet, Susette
AU - Santos-Preciado, Jose Ignacio
AU - Gans, Hayley
AU - Lew-Yasukawa, Linda
AU - Maldonado, Yvonne A.
AU - Arvin, Ann M.
AU - Valdespino-Gómez, José Luis
T1 - Induction of Cellular and Humoral Immunity after Aerosol or Subcutaneous Administration of Edmonston-Zagreb Measles Vaccine as a Primary Dose to 12-Month-Old Children.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/01/15/
VL - 189
IS - 2
M3 - Article
SP - 254
EP - 257
SN - 00221899
AB - Infants were immunized by aerosol (10(3.6) plaque-forming units [pfu]/dose) or subcutaneous (sc) (10(4.27) pfu/dose) administration of Edmonston-Zagreb measles vaccine. Measles-specific T cell proliferative responses with a stimulation index of ≥3 developed in 72% of children given aerosol-administered vaccine, compared with 87% given sc-administered vaccine (P =.06). Seroconversion rates were 90% after aerosol-administered vaccine and 100% after sc-administered vaccine (P=.01), and measles geometric mean titers were 237 milli-international units (mIU) (95% confidence interval [CI], 146-385 mIU) and 487 mIU (95% CI, 390-609 mIU) in each group, respectively (P=.01). Measles-specific T and B cell responses were weaker after aerosol than after sc vaccination, indicating a need to use a higher aerosol dose to achieve optimal immunogenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cellular immunity
KW - Immunity
KW - Aerosols (Sprays)
KW - Measles vaccine
KW - Infants
KW - T cells
KW - B cells
N1 - Accession Number: 11977926; Wong-chew, Rosa María 1; Email Address: rmwong@correo.unam.mx; Islas-Romero, Rocío 2; García-García, Maria De Lourdes 2; Beeler, Judy A. 3; Audet, Susette 3; Santos-Preciado, Jose Ignacio 1,4; Gans, Hayley 5; Lew-Yasukawa, Linda 5; Maldonado, Yvonne A. 5; Arvin, Ann M. 5; Valdespino-Gómez, José Luis 2; Affiliations: 1: Universidad Nacional Autónoma do México, Secretaría de Salud, Moxico City.; 2: lnstituto Nacional de Salud Pública, Cuornavaca, Morelos, Mexico.; 3: US Food and Drug Administration, Rockville, Maryland.; 4: Contro Nacional para la Salud do la Infancia y Adolescencia, Secretaría de Salud, Moxico City.; 5: Stanford University School of Medicine, Stanford, California.; Issue Info: 1/15/2004, Vol. 189 Issue 2, p254; Thesaurus Term: Cellular immunity; Thesaurus Term: Immunity; Thesaurus Term: Aerosols (Sprays); Subject Term: Measles vaccine; Subject Term: Infants; Subject Term: T cells; Subject Term: B cells; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hampshire, Victoria
T1 - Emerging issues regarding informed consent.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2004/01/15/
VL - 224
IS - 2
M3 - Article
SP - 177
EP - 177
SN - 00031488
AB - Reports that the staff at the U.S. Food and Drug Administration's Center for Veterinary Medicine has conducted a two-year review of consumer messages to the adverse drug experience hotline. Increasing concern by consumers about risk and benefit of commonly prescribed, approved animal drugs; Observation that pet owners are increasingly relying on Internet sources for information when their pets have problems.
KW - VETERINARY medicine
KW - ONLINE information services
KW - VETERINARY drugs
KW - ANIMAL health
KW - DRUGS -- Side effects
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 12291971; Hampshire, Victoria 1; Affiliation: 1: Office of Surveillance and Compliance, FDA Center for Veterinary Medicine; Source Info: 1/15/2004, Vol. 224 Issue 2, p177; Subject Term: VETERINARY medicine; Subject Term: ONLINE information services; Subject Term: VETERINARY drugs; Subject Term: ANIMAL health; Subject Term: DRUGS -- Side effects; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kapoor, Gurpreet S.
AU - Yi Zhan, Gurpreet S.
AU - Johnson, Gibbes R.
AU - O'Rourke, Donald M.
T1 - Distinct Domains in the SHP-2 Phosphatase Differentially Regulate Epidermal Growth Factor Receptor/NF-κB Activation through Gab1 in Glioblastoma Cells.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2004/01/15/
VL - 24
IS - 2
M3 - Article
SP - 823
EP - 836
SN - 02707306
AB - The transcription factor nuclear factor κB (NF-κB) plays an important role in inflammation and cancer, is activated by a variety of stimuli including tumor necrosis factor alpha, interleukin-1, UV irradiation, and viruses, as well as receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR). Although previous studies suggest that EGFR can induce NF-κB, the mechanism of this activation remains unknown. In this study, we identify the components of the EGFR-induced signalosome in human glioblastoma cells required to regulate NF-κB activation. Immunoprecipitation analyses with ErbB-modulated cells indicate that association between SHP-2 and Grb2-associated binder 1 (Gab1) is the critical step in the formation of the signalosome linking EGFR to NF-κB activation. We also show that EGFR-induced NF-κB activation is mediated by the PI3-kinase/Akt activation loop. Overexpression of SHP-2, Gab1, and myristoylated Akt significantly upregulated NF-κB transcriptional activity and DNA binding activity in glioblastoma cells. Interestingly, overexpression of either one of the two SH2 domain mutants of SHP-2, R32E or R138E, slightly reduced NF-κB activity relative to that of wild-type SHP-2, indicating that the SH2 domains of SHP-2 are required for EGFR-induced NF-κB activation. On the other hand, ectopic overexpression of either a Gab1 mutant incapable of binding to SHP-2 (Y627F) or a phosphatase-inactive SHP-2 mutant (C459S) caused a significant increase in NF-κB activity. Moreover, SHP-2 C459S-expressing cells displayed higher Gab1 phosphotyrosine content, suggesting that SHP-2 regulates Gab1 phosphorylation through its phosphatase domain, which confers a negative regulatory effect on NF-κB activity. These results indicate that SHP-2/Gab1 association is critical for linking EGFR to NF-κB transcriptional activity via the PI3-kinase/Akt signaling axis in glioblastoma cells and that SHP-2 acts as a dual regulator of NF-κB activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATASES
KW - EPIDERMAL growth factor
KW - GLIOBLASTOMA multiforme
KW - CELLS
KW - TRANSCRIPTION factors
KW - NF-kappa B (DNA-binding protein)
N1 - Accession Number: 12259647; Kapoor, Gurpreet S. 1 Yi Zhan, Gurpreet S. 1 Johnson, Gibbes R. 2 O'Rourke, Donald M. 1,3; Email Address: orourked@mail.med.upenn.edu; Affiliation: 1: Department of Neursurgery, University of Pennsylvania School of Medicine 2: Center for Biologics Evaluation and Research, Food and Drug Administration 3: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine; Source Info: Jan2004, Vol. 24 Issue 2, p823; Subject Term: PHOSPHATASES; Subject Term: EPIDERMAL growth factor; Subject Term: GLIOBLASTOMA multiforme; Subject Term: CELLS; Subject Term: TRANSCRIPTION factors; Subject Term: NF-kappa B (DNA-binding protein); Number of Pages: 14p; Illustrations: 13 Black and White Photographs, 2 Diagrams, 8 Graphs; Document Type: Article
L3 - 10.1128/MCB.24.2.823-836.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rockett, John C.
AU - Burczynski, Michael E.
AU - Fornace Jr., Albert J.
AU - Herrmann, Paul C.
AU - Krawetz, Stephen A.
AU - Dix, David J.
T1 - Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/01/15/
VL - 194
IS - 2
M3 - Article
SP - 189
SN - 0041008X
AB - Genomics and proteomics have made it possible to define molecular physiology in exquisite detail, when tissues are accessible for sampling. However, many tissues are not accessible for human diagnostic evaluations or experimental studies, creating the need for surrogates that afford insight into exposures and effects in such tissues. Surrogate tissue analysis (STA) incorporating contemporary genomic and proteomic technologies may be useful in determining toxicant exposure and effect, or disease state, in target tissues at the pre- or early clinical stage. We present here a discussion of STA based on presentations given at the Society of Toxicology''s 2003 annual meeting''s “Innovations in Applied Toxicology” symposium. Speakers at the symposium (Box 1) discussed various potential applications of STA, including the use of peripheral blood lymphocytes (PBLs) as a source of genetic biomarkers to monitor radiation exposure; the use of gene expression analysis of PBLs and hair follicles as a means to monitor the impact of toxicants on inaccessible organs; the characterization of disease-associated gene signatures in peripheral blood mononuclear cells (PBMCs) of renal cell carcinoma (RCC) patients; the use of sperm RNA to determine genetic and environmental effects on sperm development in the testis; and the use of serum protein profiles to monitor the development and progression of various cancers. Also discussed are some of the challenges that must be overcome if the utility of STA is to be proven, and thus permit researchers to move this concept from the laboratory to the clinical environment. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Physiology
KW - Toxicology
KW - Genomics
KW - Tissues
KW - Disease states
KW - Hair follicles
KW - Ionizing radiation
KW - Peripheral blood lymphocytes
KW - Peripheral blood mononuclear cells
KW - Proteomics
KW - Renal cell carcinoma
KW - Sperm
KW - surrogate tissue analysis (STA)
KW - Toxicity
N1 - Accession Number: 11960910; Rockett, John C. 1; Email Address: rockett.john@epa.gov; Burczynski, Michael E. 2; Fornace Jr., Albert J. 3; Herrmann, Paul C. 4; Krawetz, Stephen A. 5; Dix, David J. 1; Affiliations: 1: Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA; 2: Discovery Medicine, Wyeth Research, Cambridge, MA 01810, USA; 3: Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA; 5: Molecular Medicine and Genetics, Institute of Scientific Computing, NICHD Reproductive Medicine Network, Wayne State University, Detroit, MI 48201, USA; Issue Info: Jan2004, Vol. 194 Issue 2, p189; Thesaurus Term: Physiology; Thesaurus Term: Toxicology; Subject Term: Genomics; Subject Term: Tissues; Author-Supplied Keyword: Disease states; Author-Supplied Keyword: Hair follicles; Author-Supplied Keyword: Ionizing radiation; Author-Supplied Keyword: Peripheral blood lymphocytes; Author-Supplied Keyword: Peripheral blood mononuclear cells; Author-Supplied Keyword: Proteomics; Author-Supplied Keyword: Renal cell carcinoma; Author-Supplied Keyword: Sperm; Author-Supplied Keyword: surrogate tissue analysis (STA); Author-Supplied Keyword: Toxicity; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2003.09.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keller, James E.
AU - Fang Cai
AU - Neale, Elaine A.
T1 - Uptake of Botulinum Neurotoxin into Cultured Neurons.
JO - Biochemistry
JF - Biochemistry
Y1 - 2004/01/20/
VL - 43
IS - 2
M3 - Article
SP - 526
EP - 532
SN - 00062960
AB - Botulinum neurotoxins (BoNTs) act within the synaptic terminal to block neurotransmitter release. The toxin enters the neuron by binding to neuronal membrane receptor(s), being taken up into an endosome-like compartment, and penetrating the endosome membrane via a pH-dependent translocation process. Once within the synaptic cytoplasm, BoNT serotypes A and E cleave separate sites on the C-terminus of the neuronal protein SNAP-25, one of the SNARE proteins required for synaptic vesicle fusion. In this study, we measured the effect of brief toxin exposure on SNAP-25 proteolysis in neuronal cell cultures as an indicator of toxin translocation. The results indicate that (1) uptake of both BoNT-A and -E is enhanced with synaptic activity induced by K[sup+] depolarization in the presence of Ca[SUP2+] and (2) translocation of BoNT-A from the acidic endosomal compartment is slow relative to that of BoNT-E. Polyclonal antisera against each toxin protect cells when applied with the toxin during stimulation but has no effect when added immediately after toxin exposure, indicating that toxin endocytosis occurs with synaptic activity. Both serotypes cleave SNAP-25 at concentrations between 50 pM and 4 nM. IC[SUB50] values for SNAP-25 cleavage are approximately 0.5 nM for both serotypes. Inhibition of the pH-dependent translocation process by pretreating cultures with concanamycin A (Con A) prevents cleavage of SNAP-25 with IC[SUB50] values of ∼25 nM. Addition of Con A at times up to 15 min after toxin exposure abrogated BoNT-A action; however, addition of Con A after 40 min was no longer protective. In contrast, Con A inhibited, but did not prevent, translocation of BoNT-E even when added immediately after toxin exposure, indicating that pH-dependent translocation of BoNT-E is rapid relative to that of BoNT-A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BOTULINUM toxin
KW - NEUROTOXIC agents
KW - NEUROTRANSMITTERS
KW - NERVOUS system
KW - CELL culture
KW - ENDOCYTOSIS
N1 - Accession Number: 12202863; Keller, James E. 1,2; Email Address: kellerj@cber.fda.gov Fang Cai 2 Neale, Elaine A. 1; Affiliation: 1: Laboratory of Developmental Neurobiology, National Institute of Child Health, Human Development, National Institutes of Health, Bethesda, Maryland 20892. 2: Laboratory of Bacterial Toxins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892.; Source Info: 1/20/2004, Vol. 43 Issue 2, p526; Subject Term: BOTULINUM toxin; Subject Term: NEUROTOXIC agents; Subject Term: NEUROTRANSMITTERS; Subject Term: NERVOUS system; Subject Term: CELL culture; Subject Term: ENDOCYTOSIS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Samore, Matthew H.
AU - Evans, R. Scott
AU - Lassen, April
AU - Gould, Patricia
AU - Lloyd, James
AU - Gardner, Reed M.
AU - Abouzelof, Rouett
AU - Taylor, Carrie
AU - Woodbury, Don A.
AU - Willy, Mary
AU - Bright, Roselie A.
T1 - Surveillance of Medical Device–Related Hazards and Adverse Events in Hospitalized Patients.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/01/21/
VL - 291
IS - 3
M3 - Article
SP - 325
EP - 334
SN - 00987484
AB - Context: Although adverse drug events have been extensively evaluated by computer-based surveillance, medical device errors have no comparable surveillance techniques. Objectives: To determine whether computer-based surveillance can reliably identify medical device–related hazards (no known harm to patient) and adverse medical device events (AMDEs; patient experienced harm) and to compare alternative methods of detection of device-related problems. Design, Setting, and Participants: This descriptive study was conducted from January through September 2000 at a 520-bed tertiary teaching institution in the United States with experience in using computer tools to detect and prevent adverse drug events. All 20 441 regular and short-stay patients (excluding obstetric and newborn patients) were included. Main Outcome Measures: Medical device events as detected by computer-based flags, telemetry problem checklists, International Classification of Diseases, Ninth Revision (ICD-9) discharge code (which could include AMDEs present at admission), clinical engineering work logs, and patient survey results were compared with each other and with routine voluntary incident reports to determine frequencies, proportions, positive predictive values, and incidence rates by each technique. Results: Of the 7059 flags triggered, 552 (7.8%) indicate a device-related hazard or AMDE. The estimated 9-month incidence rates (number per 1000 admissions [95% confidence intervals]) for AMDEs were 1.6 (0.9-2.5) for incident reports, 27.7 (24.9-30.7) for computer flags, and 64.6 (60.4-69.1) for ICD-9 discharge codes. Few of these events were detected by more than 1 surveillance method, giving an overall incidence of AMDE detected by at least 1 of these methods of 83.7 per 1000 (95% confidence interval, 78.8-88.6) admissions. The positive predictive value of computer flags for detecting device-related hazards and AMDEs ranged from 0% to 38%. Conclusions: More intensive surveillance methods yielded higher rates of medical device problems than found with traditional voluntary reporting, with little overlap between methods. Several detection methods had low efficiency in detecting AMDEs. The high rate of AMDEs suggests that AMDEs are an important patient safety issue, but additional research is necessary to identify optimal AMDE detection strategies. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - MEDICAL errors
KW - PRODUCT liability -- Medical instruments & apparatus
KW - MEDICINE -- Practice
KW - Adverse Reaction
KW - Equipment Safety
KW - Medical Device Safety
KW - Quality of Health Care
N1 - Accession Number: 12019946; Samore, Matthew H. 1 Evans, R. Scott 1 Lassen, April 1 Gould, Patricia 1 Lloyd, James 1 Gardner, Reed M. 1 Abouzelof, Rouett 1 Taylor, Carrie 1 Woodbury, Don A. 1 Willy, Mary 1 Bright, Roselie A. 1; Affiliation: 1: University of Utah School of Medicine (Drs Samore, Evans, and Gardner), LDS Hospital/Intermountain Health Care (Drs Samore and Evans, Mss Lassen, Gould, Abouzelof, and Taylor, and Mssrs Lloyd and Woodbury), and Veterans Affairs Salt Lake City Health Care System, Salt Lake City; Center for Drug Evaluation and Research (Dr Willy) and Center for Devices and Radiological Health (Dr Bright), Food and Drug Administration, Rockville, Md. Ms Lassen is now with Alta View Hospital, Sandy, Utah.; Source Info: 1/21/2004, Vol. 291 Issue 3, p325; Subject Term: MEDICAL equipment; Subject Term: MEDICAL errors; Subject Term: PRODUCT liability -- Medical instruments & apparatus; Subject Term: MEDICINE -- Practice; Author-Supplied Keyword: Adverse Reaction; Author-Supplied Keyword: Equipment Safety; Author-Supplied Keyword: Medical Device Safety; Author-Supplied Keyword: Quality of Health Care; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Wu, Yuh-Shen
AU - Fu, Peter Pi-Cheng
AU - Yang, I-Lin
AU - Chen, Ming-Hsiang
T1 - Polycyclic aromatic hydrocarbons in the ambient air of suburban and industrial regions of central Taiwan
JO - Chemosphere
JF - Chemosphere
Y1 - 2004/01/22/
VL - 54
IS - 4
M3 - Article
SP - 443
SN - 00456535
AB - The concentrations of gas-phase and particle-bound polycyclic aromatic hydrocarbons (PAHs) were measured simultaneously at an industrial area (Taichung Industrial Park) and a suburban area (Tunghai University Campus) in Taichung, Taiwan. Twenty-four hours samplings for two consecutive days were performed between August and December 2002 at both sampling sites. Ambient air particle-bound PAHs were collected on quartz filters and gas-phase PAHs were collected on glass cartridges using a PUF Sampler, respectively. Both types of samples were extracted with a DCM/n-hexane mixture (50/50, v/v) for 24 h, then the extracts were subjected to gas chromatography–mass spectrometric (GC–MS) analysis. Total PAHs concentrations at the Taichung Industrial Park (TIP) sampling site and the Tunghai University Campus (THUC) sampling site were found to be 1232.3 ± 963.6 and 609.8 ± 356.3 ng/m3, respectively. Stationary combustion processes were mainly responsible for PAHs sources at the TIP sampling site, while traffic vehicle exhaust was the largest contributor for PAHs sources at the THUC sampling site. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCYCLIC aromatic hydrocarbons
KW - INDUSTRIAL districts
KW - GASES
KW - HYDROCARBONS
KW - GAS chromatography
KW - TAIWAN
KW - T -test
KW - Ambient air
KW - BaP
KW - Industrial
KW - Suburban
KW - Taichung
N1 - Accession Number: 11206789; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw Wu, Yuh-Shen 1 Fu, Peter Pi-Cheng 2 Yang, I-Lin 3 Chen, Ming-Hsiang 3; Affiliation: 1: Department of Environmental Engineering, Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan; Source Info: Jan2004, Vol. 54 Issue 4, p443; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: INDUSTRIAL districts; Subject Term: GASES; Subject Term: HYDROCARBONS; Subject Term: GAS chromatography; Subject Term: TAIWAN; Author-Supplied Keyword: T -test; Author-Supplied Keyword: Ambient air; Author-Supplied Keyword: BaP; Author-Supplied Keyword: Industrial; Author-Supplied Keyword: Suburban; Author-Supplied Keyword: Taichung; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/S0045-6535(03)00706-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huffman, L.J.
AU - Frazer, D.G.
AU - Prugh, D.J.
AU - Brumbaugh, K.
AU - Platania, C.
AU - Reynolds, J.S.
AU - Goldsmith, W.T.
T1 - Enhanced Pulmonary Inflammatory Response to Inhaled Endotoxin in Pregnant Rats.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/01/23/
VL - 67
IS - 2
M3 - Article
SP - 125
EP - 144
SN - 15287394
AB - Evidence suggests that pregnant animals are more sensitive than nonpregnant animals to the systemic administration of endotoxin. Studies were undertaken to assess whether an enhanced sensitivity of the pulmonary system to aerosolized endotoxin might exist during pregnancy. Pregnant Sprague-Dawley female rats (17 d of gestation) or age-matched virgin female rats were exposed to air or endotoxin (lipopolysaccharide) by inhalation for 3 h. At 18 h following exposure to endotoxin, lactate dehydrogenase activity levels in bronchoalveolar lavage (BAL) fluid samples from pregnant rats were 1.5-fold greater than those from endotoxin-exposed virgin rats. BAL polymorphonuclear leukocyte (PMN) numbers were also approximately twofold greater in pregnant rats than in virgins following the inhalation of endotoxin. The increases in BAL PMNs in pregnant rats following endotoxin exposure were observed just following exposure to endotoxin as well as at 18 h following exposure. These results indicate that an increased pulmonary inflammatory response to inhaled endotoxin occurs during pregnancy in rats. Additional findings suggest that these pregnancy-linked pulmonary responses to endotoxin cannot be explained by the following potential mechanisms: changes in the inhaled dose of endotoxin, or alterations in the responsiveness of alveolar macrophages to endotoxin. To our knowledge this is the first study that has evaluated pulmonary responses to inhaled endotoxin during pregnancy. Our finding that pregnancy is associated with an increased lung inflammatory response to aerosolized endotoxin raises the possibility that there may be a generalized enhancement of pulmonary responses to inhaled toxic agents during pregnancy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - INFLAMMATION
KW - PREGNANCY in animals
KW - RATS
N1 - Accession Number: 11692426; Huffman, L.J. 1; Email Address: ljh3@cdc.gov Frazer, D.G. 1 Prugh, D.J. 2 Brumbaugh, K. 2 Platania, C. 2 Reynolds, J.S. 2 Goldsmith, W.T. 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and health, and Department of Physiology and Pharmacology, West Virginia University School of Medicine 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health; Source Info: 2004, Vol. 67 Issue 2, p125; Subject Term: ENDOTOXINS; Subject Term: INFLAMMATION; Subject Term: PREGNANCY in animals; Subject Term: RATS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Cochi, Stephen L.
AU - DeStefano, Frank
AU - Herger, Wally
T1 - Letters.
JO - National Journal
JF - National Journal
Y1 - 2004/01/24/
VL - 36
IS - 4
M3 - Letter
SP - 212
EP - 212
PB - National Journal Group, Inc.
SN - 03604217
AB - Presents letters to the editor referencing articles and topics discussed in previous issues. "Missing the Mercury Menace?," which focused on erroneous and misleading statements regarding thimerosal-containing vaccines and autism; "What Works for Welfare?," which discussed public welfare reform in the U.S.
KW - LETTERS to the editor
KW - VACCINES
KW - PREVENTIVE medicine
KW - PUBLIC welfare
KW - HUMAN services
N1 - Accession Number: 12344884; Cochi, Stephen L. 1 DeStefano, Frank 2 Herger, Wally 3; Affiliation: 1: Captain, United States Public Health Service, Acting Deputy Director 2: Medical Epidemiologist, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga. 3: Rep., R-Calif., Chairman, House Ways and Means Human Resources Subcommittee; Source Info: 1/24/2004, Vol. 36 Issue 4, p212; Subject Term: LETTERS to the editor; Subject Term: VACCINES; Subject Term: PREVENTIVE medicine; Subject Term: PUBLIC welfare; Subject Term: HUMAN services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 1p; Document Type: Letter; Full Text Word Count: 950
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Michael Marcy, S.
AU - Kohl, Katrin S.
AU - Dagan, Ron
AU - Nalin, David
AU - Blum, Michael
AU - Jones, Marcy Connell
AU - Hansen, John
AU - Labadie, Jerry
AU - Lee, Lucia
AU - Martin, Bryan L.
AU - O’Brien, Katherine
AU - Rothstein, Edward
AU - Vermeer, Patricia
T1 - Fever as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation
JO - Vaccine
JF - Vaccine
Y1 - 2004/01/26/
VL - 22
IS - 5/6
M3 - Article
SP - 551
SN - 0264410X
KW - Adverse events following immunization
KW - Case definition
KW - Fever
KW - Guidelines
N1 - Accession Number: 11966352; Michael Marcy, S. 1 Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org Dagan, Ron 3 Nalin, David 4 Blum, Michael 5 Jones, Marcy Connell 6 Hansen, John 7 Labadie, Jerry 8 Lee, Lucia 9 Martin, Bryan L. 10 O’Brien, Katherine 11 Rothstein, Edward 12 Vermeer, Patricia 13,14,15; Affiliation: 1: Harbor-UCLA Medical Center, USA and Kaiser-Permanente Health Care Program, CA, USA 2: Centers for Disease Control and Prevention, National Immunization Program, 1600 Clifton Rd., Mailstop E-61, Atlanta, GA 30333, USA 3: Soroka Medical Center, Beer Sheva, Israel 4: Merck & Co., West Point, PA, USA 5: Wyeth Research, Collegeville, PA, USA 6: California DHS Immunization Branch, Berkeley, CA, USA 7: Kaiser Permanente Health Care Program, Oakland, CA, USA 8: Netherlands Pharmacovigilance Centre Lareb, s-Hertogenbosch, The Netherlands 9: Food and Drug Administration, Rockville, MD, USA 10: Walter Reed Army Medical Center, Washington, DC, USA 11: The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA 12: Pennridge Pediatrics Associates, Sellersville, PA, USA 13: National Institute of Public Health and Environment, Bilthoven, The Netherlands 14: Centers for Disease Control and Prevention, Atlanta, GA, USA 15: University Children’s Hospital, Basel, Switzerland; Source Info: Jan2004, Vol. 22 Issue 5/6, p551; Author-Supplied Keyword: Adverse events following immunization; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Fever; Author-Supplied Keyword: Guidelines; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.09.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bonhoeffer, Jan
AU - Gold, Michael S
AU - Heijbel, Harald
AU - Vermeer, Patricia
AU - Blumberg, Dean
AU - Braun, Miles
AU - de Souza-Brito, Glacus
AU - Davis, Robert L
AU - Halperin, Scott
AU - Heininger, Ulrich
AU - Khuri-Bulos, Najwa
AU - Menkes, John
AU - Nokleby, Hanne
T1 - Hypotonic-Hyporesponsive Episode (HHE) as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation
JO - Vaccine
JF - Vaccine
Y1 - 2004/01/26/
VL - 22
IS - 5/6
M3 - Article
SP - 563
SN - 0264410X
N1 - Accession Number: 11966354; Bonhoeffer, Jan 1; Email Address: secretariat@brightoncollaboration.org Gold, Michael S 2 Heijbel, Harald 3 Vermeer, Patricia 4 Blumberg, Dean 5 Braun, Miles 6 de Souza-Brito, Glacus 7 Davis, Robert L 8 Halperin, Scott 9 Heininger, Ulrich 1 Khuri-Bulos, Najwa 10 Menkes, John 11 Nokleby, Hanne 1,12,13; Affiliation: 1: University Children’s Hospital, Basle, Switzerland 2: University Department of Paediatrics, Adelaide, Australia 3: Swedish Institute of Infectious Disease Control, Lund, Sweden 4: National Institute of Public Health and Environment, Bilthoven, The Netherlands 5: UC Davis Medical Center, Sacramento, California, USA 6: Food and Drug Administration, Rockville, MD, USA 7: University Medical School, Sao Paolo, Brazil 8: University of Washington, Seattle, Washington, USA 9: Dalhousie University, Halifax, Nova Scotia, Canada 10: Jordan University Hospital, Amman, Jordan 11: Cedars Sinai Medical Center, Los Angeles, CA, USA 12: National Institute of Public Health, Oslo, Norway 13: Centers for Disease Control and Prevention, Atlanta, GA, USA; Source Info: Jan2004, Vol. 22 Issue 5/6, p563; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.09.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rothstein, Edward
AU - Kohl, Katrin S.
AU - Ball, Leslie
AU - Halperin, Scott A.
AU - Halsey, Neal
AU - Hammer, Sandra Jo
AU - Heath, Paul T.
AU - Hennig, Renald
AU - Kleppinger, Cynthia
AU - Labadie, Jerry
AU - Varricchio, Frederick
AU - Vermeer, Patricia
AU - Walop, Wikke
T1 - Nodule at injection site as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation
JO - Vaccine
JF - Vaccine
Y1 - 2004/01/26/
VL - 22
IS - 5/6
M3 - Article
SP - 575
SN - 0264410X
N1 - Accession Number: 11966356; Rothstein, Edward 1 Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org Ball, Leslie 3 Halperin, Scott A. 4 Halsey, Neal 5 Hammer, Sandra Jo 6 Heath, Paul T. 7 Hennig, Renald 8 Kleppinger, Cynthia 3 Labadie, Jerry 9 Varricchio, Frederick 3 Vermeer, Patricia 10 Walop, Wikke 11,12,13; Affiliation: 1: Pennridge Pediatric Associates, Sellersville, PA, USA 2: Centers for Disease Control and Prevention, National Immunization Program, 1600 Clifton Rd, Mailstop E-61, Atlanta, GA 30333, USA 3: Food and Drug Administration, Rockville, MD, USA 4: Dalhousie University, Halifax, Nova Scotia, Canada 5: The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 6: California Department of Health Services, Berkeley, CA, USA 7: St George’s Hospital Medical School, London, UK 8: Chiron Behring GmbH & Co, Marburg, Germany 9: Netherlands Pharmacovigilance Centre Lareb, ’s-Hertogenbosch, The Netherlands 10: National Institute of Public Health and Environment, Bilthoven, The Netherlands 11: Health Canada, Ottawa, Ontario, Canada 12: Centers for Disease Control and Prevention, Atlanta, GA, USA 13: University Children's Hospital, Basle, Switzerland; Source Info: Jan2004, Vol. 22 Issue 5/6, p575; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.09.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106742377
T1 - Preventing foodborne disease -- what clinicians can do.
AU - Acheson DWK
AU - Fiore AE
Y1 - 2004/01/29/
N1 - Accession Number: 106742377. Language: English. Entry Date: 20040604. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Food Contamination -- Prevention and Control
KW - Hepatitis A -- Prevention and Control
KW - Viral Hepatitis Vaccines
KW - Disease Outbreaks -- Prevention and Control
KW - Food Handling
KW - Food Poisoning -- Diagnosis
KW - Food Poisoning -- Microbiology
KW - Hepatitis A -- Transmission
KW - United States Food and Drug Administration
SP - 437
EP - 440
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 350
IS - 5
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD
U2 - PMID: 14749450.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106742377&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sakamoto, Shuji
AU - Jinzhong Qin
AU - Navarro, Angels
AU - Gamero, Ana
AU - Potla, Ramesh
AU - Taolin Yi
AU - Wei Zhu
AU - Baker, Darre P.
AU - Feldman, Gerald
AU - Larner, Andrew C.
T1 - Cells Previously Desensitized to Type 1 Interferons Display Different Mechanisms of Activation of Stat-dependent Gene Expression from Naïve Cells.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/01/30/
VL - 279
IS - 5
M3 - Article
SP - 3245
EP - 3253
SN - 00219258
AB - Over the past decade, a wealth of knowledge has been obtained concerning the mechanisms by which interferons (IFNs) and other cytokines activate or down-regulate immediate early genes via the Jak/Stat pathway. In contrast, little information is available on interferonactivated gene expression in naive cells compared with cells that have been desensitized and subsequently resensitized to the actions of these cytokines. In naïve cells, the ISG54 gene is activated via IFNβ-stimulated formation of ISGF3, a heterotrimeric DNA binding complex consisting of p48 (IRF9) and tyrosine-phosphorylated Stat1 and Stat2. In contrast, in previously desensitized cells IFNβ weakly stimulates the assembly of an ISGF3-like complex that lacks Stat1, even though ISG54 mRNA induction is the same as in naive cells. The lack of Stat1 tyrosine phosphorylation and DNA binding is due to increased activity of a protein-tyrosine phosphatase. In cells that do not express the tyrosine phosphatase Tc-PTP, the rate of Stat1 dephosphorylation is the same in naive and previously desensitized cells. These results implicate Tc-PTP in a novel role in the regulation of type 1 interferon-stimulated gene expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - CYTOKINES
KW - GENE expression
KW - CELLS
KW - PROTEIN binding
KW - DNA
N1 - Accession Number: 12354737; Sakamoto, Shuji 1 Jinzhong Qin 1 Navarro, Angels 1 Gamero, Ana 1 Potla, Ramesh 1 Taolin Yi 2 Wei Zhu 1 Baker, Darre P. 3 Feldman, Gerald Larner, Andrew C. 1; Email Address: larnera@ccf.iorg; Affiliation: 1: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation 2: Department of Cancer Biology 3: Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration; Source Info: 1/30/2004, Vol. 279 Issue 5, p3245; Subject Term: INTERFERONS; Subject Term: CYTOKINES; Subject Term: GENE expression; Subject Term: CELLS; Subject Term: PROTEIN binding; Subject Term: DNA; Number of Pages: 9p; Illustrations: 18 Graphs; Document Type: Article
L3 - 10.1074/jbc.M309631200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carmona, R.
AU - Gfroerer, J.
AU - Caraballo, R.
AU - Yee, S. L.
AU - Husten, C.
AU - Pechacek, T.
AU - Robinson, R. G.
AU - Lee, C.
T1 - Prevalence of Cigarette Use Among 14 Racial/Ethnic Populations -- United States, 1999-2001. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/01/30/
VL - 53
IS - 3
M3 - Article
SP - 49
EP - 52
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Discusses the prevalence of cigarette use among racial/ethnic populations in the U.S. during 1999-2001. Primary racial/ethnic minority populations in the country; Data used for the "Tobacco Use Among U.S. Racial/Ethnic Minority Groups" report of the U.S. Surgeon General; Prevalence of cigarette use among youths.
KW - CIGARETTE smokers
KW - SMOKING
KW - TEENAGERS
KW - MINORITIES
KW - ETHNIC groups
KW - RESEARCH
KW - UNITED States
KW - UNITED States. Public Health Service. Office of the Surgeon General
N1 - Accession Number: 12148074; Carmona, R. 1 Gfroerer, J. 2 Caraballo, R. 3 Yee, S. L. 3 Husten, C. 3 Pechacek, T. 3 Robinson, R. G. 3 Lee, C. 4; Affiliation: 1: Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion 2: Office of Applied Studies, Substance Abuse and Mental Health Svcs Admin., National Center for Chronic Disease Prevention and Health Promotion 3: Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion 4: EIS Officer, CDC; Source Info: 1/30/2004, Vol. 53 Issue 3, p49; Subject Term: CIGARETTE smokers; Subject Term: SMOKING; Subject Term: TEENAGERS; Subject Term: MINORITIES; Subject Term: ETHNIC groups; Subject Term: RESEARCH; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service. Office of the Surgeon General; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106731259
T1 - Screening for type 2 diabetes mellitus in adults.
AU - Fink K
AU - Clark B
Y1 - 2004/02//2/1/2004
N1 - Accession Number: 106731259. Language: English. Entry Date: 20040507. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Diabetes Mellitus, Type 2 -- Diagnosis
KW - Diabetes Mellitus, Type 2 -- Prevention and Control
KW - Cardiovascular Risk Factors -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Female
KW - Hyperlipidemia -- Complications
KW - Hypertension -- Complications
KW - Medical Practice, Evidence-Based
KW - Middle Age
KW - Preventive Health Care
SP - 605
EP - 749
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 69
IS - 3
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - Putting prevention into practice: an evidence-based approach series
SN - 0002-838X
AD - Program Director, US Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality
U2 - PMID: 14971844.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106731259&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Erickson, Jill Shepard
T1 - PREFACE.
JO - American Indian & Alaska Native Mental Health Research: The Journal of the National Center
JF - American Indian & Alaska Native Mental Health Research: The Journal of the National Center
Y1 - 2004/02//
VL - 11
IS - 2
M3 - Article
SP - 1
EP - 1
PB - University of Colorado Denver
SN - 15337731
AB - Presents information on the Circles of Care initiative launched through a collaboration of several health agencies in the U.S. which aims to address critical health policy issues affecting mental health care system for children and families of American Indian and Alaska Native communities. Mental health care professionals involved in the initiative; Members of the advisory board of the initiative.
KW - CHILD health services
KW - CHILD mental health services
KW - MENTAL health services
KW - PUBLIC health
KW - NATIVE Americans
KW - UNITED States
N1 - Accession Number: 14297886; Erickson, Jill Shepard 1; Affiliation: 1: Center for Mental Health Services, Substance Abuse and Mental Health Services, Administration Suite 11-C-16, 5600 Fishers Lane, Rockville, MD 20857; Source Info: 2004, Vol. 11 Issue 2, preceding p1; Subject Term: CHILD health services; Subject Term: CHILD mental health services; Subject Term: MENTAL health services; Subject Term: PUBLIC health; Subject Term: NATIVE Americans; Subject Term: UNITED States; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenblatt, Kevin P.
AU - Bryant-Greenwood, Peter
AU - Killian, J. Keith
AU - Mehta, Arpita
AU - Geho, David
AU - Espina, Virginia
AU - Liotta, Lance A.
AU - Petricoin III, Emanuel F.
T1 - SERUM PROTEOMICS IN CANCER DIAGNOSIS AND MANAGEMENT.
JO - Annual Review of Medicine
JF - Annual Review of Medicine
Y1 - 2004/02//
VL - 55
IS - 1
M3 - Article
SP - 97
EP - 112
PB - Annual Reviews Inc.
SN - 00664219
AB - Mass spectrometry-based diagnostics has the potential to revolutionize molecular medicine. Using modern mass-spectrometer technologies, clinical tests can be developed that are practical, robust, accurate, and inexpensive. Serum proteomic pattern profiling couples mass spectrometry with adaptive artificial-intelligence-based bioinformatics, which can now be employed to detect pathological states reflected in the serum proteome. With this approach, rapid and cost-effective tests with exquisite clinical sensitivity and specificity are emerging. These tools may dramatically change how disease is detected, monitored, and managed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annual Review of Medicine is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER -- Diagnosis
KW - SERUM
KW - PROTEOMICS
KW - MASS spectrometry
KW - mass spectrometry
KW - protein profiling
KW - proteomics
KW - SELDI
N1 - Accession Number: 12672584; Rosenblatt, Kevin P. 1; Email Address: rosenblk@nihexchange2.nih.gov Bryant-Greenwood, Peter 2 Killian, J. Keith 1 Mehta, Arpita 1 Geho, David 1 Espina, Virginia 1 Liotta, Lance A. 1 Petricoin III, Emanuel F. 3; Affiliation: 1: Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892 2: Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96822 3: Food and Drug Administration-National Cancer Institute Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 2004, Vol. 55 Issue 1, p97; Subject Term: CANCER -- Diagnosis; Subject Term: SERUM; Subject Term: PROTEOMICS; Subject Term: MASS spectrometry; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: protein profiling; Author-Supplied Keyword: proteomics; Author-Supplied Keyword: SELDI; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 20p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grant, Michael A.
T1 - Improved Laboratory Enrichment for Enterohemorrhagic Escherichia coli by Exposure to Extremely Acidic Conditions.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/02//
VL - 70
IS - 2
M3 - Article
SP - 1226
EP - 1230
SN - 00992240
AB - Analysis of food samples for E. coli O157:H7 using the standard U.S. Food and Drug Administration procedure is frequently complicated by overgrowth of nontarget microorganisms. A new procedure was developed for enrichment of enterohemorrhagic E. coli (EHEC) which utilizes exposure to pH 2.00 for 2 h. This procedure yielded larger populations of EHEC than the standard method by factors ranging from 2.7 to 7.7 and, when age-stressed cultures were used, by factors ranging from 2.7 to 11.5. Cultures of competing enterics were more effectively inhibited by the new enrichment protocol as well. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli O157:H7
KW - GRAM-negative bacteria
KW - FOOD -- Analysis
KW - FOOD -- Microbiology
KW - ACIDS -- Physiological effect
KW - SANITARY microbiology
N1 - Accession Number: 12591400; Grant, Michael A. 1; Email Address: mgrant@ora.fda.gov; Affiliation: 1: United States Food and Drug Administration, Bothell, Washington; Source Info: Feb2004, Vol. 70 Issue 2, p1226; Subject Term: ESCHERICHIA coli O157:H7; Subject Term: GRAM-negative bacteria; Subject Term: FOOD -- Analysis; Subject Term: FOOD -- Microbiology; Subject Term: ACIDS -- Physiological effect; Subject Term: SANITARY microbiology; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106679827
T1 - From many into one: an integrated information agenda for mental health.
AU - Manderscheid RW
AU - Henderson MJ
Y1 - 2004/02//
N1 - Accession Number: 106679827. Language: English. Entry Date: 20040416. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9308264.
KW - Clinical Information Systems
KW - Mental Health
SP - 38
EP - 41
JO - Behavioral Healthcare Tomorrow
JF - Behavioral Healthcare Tomorrow
JA - BEHAV HEALTHC TOMORROW
VL - 13
IS - 1
CY - New York, New York
PB - Vendome Group LLC
AB - Ronald W. Manderscheid, Ph.D., and Marilyn J. Henderson of the federal Center for Mental Health Services (CMHS) update the field on the major projects working toward establishing a common set of data standards for behavioral health.
SN - 1063-8490
AD - Survey and Analysis Branch, Federal Center for Mental Health Services, Substance Abuse and Mental Health Services Administration
U2 - PMID: 15002198.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wen Shi
AU - Yong Ming Wang, D.
AU - Li Shao Li, D.
AU - Min Yan
AU - Duan Li
AU - Neng Neng Chen, D.
AU - Bin Yan Chen, D.
T1 - Safety and Efficacy of Oral Nonsteroidal Anti-Inflammatory Drugs in Patients with Rheumatoid Arthritis.
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
Y1 - 2004/02//
VL - 24
IS - 2
M3 - Article
SP - 89
EP - 101
PB - Springer Science & Business Media B.V.
SN - 11732563
AB - Objective: To monitor the safety and efficacy profile of long-term treatment with diclofenac, nabumetone, meloxicam and celecoxib in patients with rheumatoid arthritis. Design and methods: This randomised, prospective clinical trial included a total of 461 subjects (313 females and 148 males) with clinically diagnosed rheumatoid arthritis. Their average age was 46.9 ± 14.4 years (range 20-69 years), and the average disease duration was 1333.7 ± 992.85 days. Subjects were randomly assigned daily administration of one of the following: diclofenac 75-100mg, meloxicam 15mg, nabumetone 1000mg or celecoxib 200mg. During the 6-month treatment period, a monthly patient interview was conducted to evaluate drug efficacy and safety. Results: 407 subjects successfully completed the 6-month treatment. Sixteen patients (12.2%) withdrew from the diclofenac group, 16 (12.2%) from the nabumetone group, 17 (11.8%) from the meloxicam group and five (9.1%) from the celecoxib group. Most withdrawals occurred during the first 3 months of treatment. Reasons for withdrawals in the first three groups were lack of efficacy (44.9%) and adverse effects (38.8%). For the celecoxib group, high cost (80%) was the main reason for withdrawal. Adverse drug reactions to NSAIDs mostly occurred at an early stage of treatment, with an incidence rate of 31.9% for the diclofenac group, 19.9% for the nabumetone group, 25.2% for the meloxicam group, and 7.27% for the celecoxib group. Clinical efficacy rates for the four NSAIDs were positively related to the length of treatment. During the first 4 months, diclofenac, meloxicam and celecoxib showed better efficacy than nabumetone. There were no significant differences in efficacy during the fifth and sixth months. The overall 6-month effectiveness rates were 68.8% for diclofenac, 59.8% for nabumetone, 67.6% for meloxicam and 69.1% for celecoxib. Conclusions: Adverse drug reactions and their related withdrawals occurred mostly at an early stage of NSAID treatment, so it is crucial to strengthen pharmacovigilance during this period. Among the investigated NSAIDs, celecoxib did not prove to be superior to diclofenac, nabumetone or meloxicam with respect to its efficacy in the treatment of rheumatoid arthritis; however, it did show good patient compliance and safety profiles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Drug Investigation is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DICLOFENAC
KW - RHEUMATOID arthritis -- Treatment
KW - CLINICAL trials
KW - DRUGS -- Effectiveness
KW - DRUGS -- Side effects
KW - ANTI-inflammatory agents
KW - NONSTEROIDAL anti-inflammatory agents
N1 - Accession Number: 12753460; Wen Shi 1 Yong Ming Wang, D. 1 Li Shao Li, D. 2 Min Yan 2 Duan Li 1 Neng Neng Chen, D. 1 Bin Yan Chen, D. 1; Affiliation: 1: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China 2: Center for Drug Reevaluation and the Center for Adverse Drug Reaction Monitoring, State Food and Drug Administration, Beijing, China; Source Info: 2004, Vol. 24 Issue 2, p89; Subject Term: DICLOFENAC; Subject Term: RHEUMATOID arthritis -- Treatment; Subject Term: CLINICAL trials; Subject Term: DRUGS -- Effectiveness; Subject Term: DRUGS -- Side effects; Subject Term: ANTI-inflammatory agents; Subject Term: NONSTEROIDAL anti-inflammatory agents; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petricoin, Emanuel F
AU - Liotta, Lance A
T1 - SELDI-TOF-based serum proteomic pattern diagnostics for early detection of cancer
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
Y1 - 2004/02//
VL - 15
IS - 1
M3 - Article
SP - 24
SN - 09581669
AB - Proteomics is more than just generating lists of proteins that increase or decrease in expression as a cause or consequence of pathology. The goal should be to characterize the information flow through the intercellular protein circuitry that communicates with the extracellular microenvironment and then ultimately to the serum/plasma macroenvironment. The nature of this information can be a cause, or a consequence, of disease and toxicity-based processes. Serum proteomic pattern diagnostics is a new type of proteomic platform in which patterns of proteomic signatures from high dimensional mass spectrometry data are used as a diagnostic classifier. This approach has recently shown tremendous promise in the detection of early-stage cancers. The biomarkers found by SELDI-TOF-based pattern recognition analysis are mostly low molecular weight fragments produced at the specific tumor microenvironment. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Biotechnology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - SERUM
KW - PROTEINS
KW - CANCER
KW - BIOCHEMICAL markers
KW - artificial intelligence (AI)
KW - mass spectroscopy (MS)
KW - surface-enhanced laser desorption/ionization (SELDI)
KW - time-of-flight (TOF)
N1 - Accession Number: 12238226; Petricoin, Emanuel F 1; Email Address: petricoin@cber.fda.gov Liotta, Lance A 2; Affiliation: 1: FDA-NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA; Source Info: Feb2004, Vol. 15 Issue 1, p24; Subject Term: PROTEOMICS; Subject Term: SERUM; Subject Term: PROTEINS; Subject Term: CANCER; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: artificial intelligence (AI); Author-Supplied Keyword: mass spectroscopy (MS); Author-Supplied Keyword: surface-enhanced laser desorption/ionization (SELDI); Author-Supplied Keyword: time-of-flight (TOF); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.copbio.2004.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fu, Peter P.
AU - Xia, Qingsu
AU - Lin, Ge
AU - Chou, Ming W.
T1 - Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms.
JO - Drug Metabolism Reviews
JF - Drug Metabolism Reviews
Y1 - 2004/02//
VL - 36
IS - 1
M3 - Article
SP - 1
EP - 55
PB - Taylor & Francis Ltd
SN - 03602532
AB - Pyrrolizidine alkaloid-containing plants are widely distributed in the world and are probably the most common poisonous plants affecting livestock, wildlife, and humans. Because of their abundance and potent toxicities, the mechanisms by which pyrrolizidine alkaloids induce genotoxicities, particularly carcinogenicity, were extensively studied for several decades but not exclusively elucidated until recently. To date, the pyrrolizidine alkaloid-induced genotoxicities were revealed to be elicited by the hepatic metabolism of these naturally occurring toxins. In this review, we present updated information on the metabolism, metabolizing enzymes, and the mechanisms by which pyrrolizidine alkaloids exert genotoxicity and tumorigenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Metabolism Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PYRROLIZIDINES
KW - POISONOUS plants
KW - CARCINOGENESIS
KW - TOXINS
KW - ENZYME activation
KW - LIVESTOCK
KW - DNA adduct
KW - Enzymes
KW - Genotoxicity Pyrrolizidine alkaloids
KW - Mechanism
KW - Metabolic activation.
KW - Metabolism
N1 - Accession Number: 12453679; Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov Xia, Qingsu 1 Lin, Ge 2 Chou, Ming W. 1; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA. 2: Department of Pharmacology, Chinese University of Hong Kong, Special Administrative Region, Shatin, Hong Kong.; Source Info: Feb2004, Vol. 36 Issue 1, p1; Subject Term: PYRROLIZIDINES; Subject Term: POISONOUS plants; Subject Term: CARCINOGENESIS; Subject Term: TOXINS; Subject Term: ENZYME activation; Subject Term: LIVESTOCK; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: Enzymes; Author-Supplied Keyword: Genotoxicity Pyrrolizidine alkaloids; Author-Supplied Keyword: Mechanism; Author-Supplied Keyword: Metabolic activation.; Author-Supplied Keyword: Metabolism; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 55p; Document Type: Article
L3 - 10.1081/DMR-120028426
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kennedy, Dianne L.
AU - Uhl, Kathleen
AU - Kweder, Sandra L.
T1 - Pancreotoxicity of Propofol Sedation during Purulent Meningitis.
JO - Drug Safety
JF - Drug Safety
Y1 - 2004/02//
VL - 27
IS - 3
M3 - Article
SP - 145
EP - 172
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Drug-induced torsade de pointes (TdP) has proved to be a significant iatrogenic cause of morbidity and mortality and a major reason for the withdrawal of a number of drugs from the market in recent times. Enzymes that metabolise many of these drugs and the potassium channels that are responsible for cardiac repolarisation display genetic polymorphisms. Anecdotal reports have suggested that in many cases of drug-induced TdP, there may be a concealed genetic defect of either these enzymes or the potassium channels, giving rise to either high plasma drug concentrations or diminished cardiac repolarisation reserve, respectively. The presence of either of these genetic defects may predispose a patient to TdP, a potentially fatal adverse reaction, even at therapeutic dosages of QT-prolonging drugs and in the absence of other risk factors. Advances in pharmacogenetics of drug metabolizing enzymes and pharmacological targets, together with the prospects of rapid and inexpensive genotyping procedures, promise to individualise and improve the benefit/risk ratio of therapy with drugs that have the potential to cause TdP. The qualitative and the quantitative contributions of these genetic defects in clinical clinical cases of TdP are unclear because not all of the patients with TdP are routinely genotyped and some relevant genetic mutations still remain to be discovered. There are regulatory guidelines that recommend strategies aimed at uncovering the risk of TdP associated with new chemical entities during their development. There are also a number of guidelines that recommend integrating pharmacogenetics in this process. This paper proposes a strategy for integrating pharmacogenetics into drug development programmes to optimise association studies correlating genetic traits and endpoints of clinical interest, namely failure of efficacy or development of repolarisation abnormalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG metabolism
KW - MENINGITIS
KW - IATROGENIC diseases
KW - POTASSIUM channels
KW - MORTALITY
KW - GENETIC polymorphisms
KW - PHARMACOGENOMICS
N1 - Accession Number: 12753937; Kennedy, Dianne L. 1 Uhl, Kathleen 1 Kweder, Sandra L. 1; Affiliation: 1: Pregnancy Labeling Task Force, Us Food and Drug Administration, Rockville, Maryland, USA.; Source Info: 2004, Vol. 27 Issue 3, p145; Subject Term: DRUG metabolism; Subject Term: MENINGITIS; Subject Term: IATROGENIC diseases; Subject Term: POTASSIUM channels; Subject Term: MORTALITY; Subject Term: GENETIC polymorphisms; Subject Term: PHARMACOGENOMICS; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ginsberg, Gary
AU - Slikker Jr., William
AU - Bruckner, James
AU - Sonawane, Babasaheb
T1 - Incorporating Children's Toxicokinetics into a Risk Framework.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/02//
VL - 112
IS - 2
M3 - Article
SP - 272
EP - 283
PB - Superintendent of Documents
SN - 00916765
AB - Children's responses to environmental toxicants will be affected by the way in which their systems absorb, distribute, metabolize, and excrete chemicals. These toxicokinetic factors vary during development, from in utero where maternal and placental processes play a large role, to the neonate in which emerging metabolism and clearance pathways are key determinants. Toxicokinetic differences between neonates and adults lead to the potential for internal dosimetry differences and increased or decreased risk, depending on the mechanisms for toxicity and clearance of a given chemical. This article raises a number of questions that need to be addressed when conducting a toxicokinetic analysis of in utero or childhood exposures. These questions are organized into a proposed framework for conducting the assessment that involves problem formulation (identification of early life stage toxicokinetic factors and chemical-specific factors that may raise questions/concerns for children); data analysis (development of analytic approach, construction of child/adult or child/animal dosimetry comparisons); and risk characterization (evaluation of how children's toxicokinetic analysis can be used to decrease uncertainties in the risk assessment). The proposed approach provides a range of analytical options, from qualitative to quantitative, for assessing children's dosimetry. Further, it provides background information on a variety of toxicokinetic factors that can vary as a function of developmental stage. For example, the ontology of metabolizing systems is described via reference to pediatric studies involving therapeutic drugs and evidence from in vitro enzyme studies. This type of resource information is intended to help the assessor begin to address the issues raised in this paper. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pollutants
KW - Developmental biology
KW - Toxicology
KW - Environmental health
KW - Environmental sciences
KW - Child development
KW - children
KW - dosimetry
KW - risk assessment
N1 - Accession Number: 12441162; Ginsberg, Gary 1; Email Address: gary.ginsberg@po.state.ct.us; Slikker Jr., William 2; Bruckner, James 3; Sonawane, Babasaheb 4; Affiliations: 1: Connecticut Department of Public Health; 2: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson Arkansas; 3: University of Georgia; 4: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency; Issue Info: Feb2004, Vol. 112 Issue 2, p272; Thesaurus Term: Pollutants; Thesaurus Term: Developmental biology; Thesaurus Term: Toxicology; Thesaurus Term: Environmental health; Thesaurus Term: Environmental sciences; Subject Term: Child development; Author-Supplied Keyword: children; Author-Supplied Keyword: dosimetry; Author-Supplied Keyword: risk assessment; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kim, Meehye
T1 - Determination of lead and cadmium in wines by graphite furnace atomic absorption spectrometry.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2004/02//
VL - 21
IS - 2
M3 - Article
SP - 154
EP - 157
PB - Taylor & Francis Ltd
SN - 0265203X
AB - The lead (Pb) and cadmium (Cd) content of various wines on the Korean market were determined by graphite furnace atomic absorption spectrometry using Zeeman background correction and peak area mode. All wine samples were microwave-digested in concentrated HNO 3 . Ammonium dihydrogen phosphate and magnesium nitrate were used as matrix modifiers for both Pb and Cd analyses. The mean Pb content of the wines was about 29 μg l -1 ranging from 5 to 87 μg l -1 . Also, the means of Cd were about 0.5 μg l -1 ranging from < 0.1 to 3.0 μg l -1 . The mean recoveries of Pb and Cd were 92.8 and 101.3% and their analytical detection limits were 1.0 and 0.1 μg l -1 , respectively. Sixty brands of wine were classified into red and white, but no statistically significant difference in Pb and Cd content was observed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lead
KW - Cadmium
KW - Wine & wine making
KW - Spectrometry
KW - Ammonium compounds
KW - Magnesium compounds
KW - cadmium
KW - graphite furnace atomic absorption spectrometry
KW - lead
KW - red wine
KW - white wine
N1 - Accession Number: 12252859; Kim, Meehye 1; Email Address: meehkim@kfda.go.kr; Affiliations: 1: Department of Food Evaluation, Korea Food and Drug Administration; Issue Info: Feb2004, Vol. 21 Issue 2, p154; Thesaurus Term: Lead; Thesaurus Term: Cadmium; Thesaurus Term: Wine & wine making; Thesaurus Term: Spectrometry; Subject Term: Ammonium compounds; Subject Term: Magnesium compounds; Author-Supplied Keyword: cadmium; Author-Supplied Keyword: graphite furnace atomic absorption spectrometry; Author-Supplied Keyword: lead; Author-Supplied Keyword: red wine; Author-Supplied Keyword: white wine; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 312130 Wineries; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/02652030310001642762
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ER -
TY - JOUR
AU - Buchanan, R.L.
AU - Edelson-Mammel, S.G.
AU - Boyd, G.
AU - Marmer, B.S.
T1 - Influence of acidulant identity on the effects of pH and acid resistance on the radiation resistance of Escherichia coli O157:H7
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004/02//
VL - 21
IS - 1
M3 - Article
SP - 51
SN - 07400020
AB - The effects of pH (4.0–5.5), acid identity (acetic, citric, lactic, malic, and hydrochloric), and the induction of pH-dependent stationary phase acid resistance on the radiation resistance of E. coli O157:H7 Ent-C9490 was studied using cells grown in Tryptic Soy Broth with and without dextrose (induced and non-induced to acid resistance) and then resuspended in brain–heart infusion broth containing 5 g/l of an organic acid and acidified with concentrated hydrochloric acid. After treatment with gamma radiation, the number of survivors was determined by plating on brain–heart infusion agar (injured and non-injured cells) and MacConkey agar (non-injured cells), and the data used to calculate radiation D-values. The induction of pH-dependent stationary phase acid resistance consistently provided the enterohemorrhagic E. coli strain cross-protection from subsequent irradiation, increasing radiation D-values by 1.2–3.3-fold, depending on the organic acid present. The radiation resistance of E. coli varied with acid identity, but was largely unaffected by pH within the range examined. The results indicate that induction of cross-protection resulting from induction of acid resistance is a factor that should be considered to accurately determine the radiation dose needed to inactivate enterohemorrhagic E. coli in foods. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - HYDROGEN-ion concentration
KW - IRRADIATION
KW - HYDROCHLORIC acid
KW - Acid tolerance
KW - Cross-protection
KW - Irradiation
KW - Organic acids
N1 - Accession Number: 11319272; Buchanan, R.L. 1; Email Address: robert.buchanan@cfsan.fda.gov Edelson-Mammel, S.G. 1 Boyd, G. 2 Marmer, B.S. 2; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA 2: USDA ARS ERRC, 600 East Mermaid Lane, Wyndmoor, PA 19038, USA; Source Info: Feb2004, Vol. 21 Issue 1, p51; Subject Term: ESCHERICHIA coli; Subject Term: HYDROGEN-ion concentration; Subject Term: IRRADIATION; Subject Term: HYDROCHLORIC acid; Author-Supplied Keyword: Acid tolerance; Author-Supplied Keyword: Cross-protection; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: Organic acids; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0740-0020(03)00039-X
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ER -
TY - JOUR
AU - Fleischman, Gregory J.
AU - Ravishankar, Sadhana
AU - Balasubramaniam, V.M.
T1 - The inactivation of Listeria monocytogenes by pulsed electric field (PEF) treatment in a static chamber
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004/02//
VL - 21
IS - 1
M3 - Article
SP - 91
SN - 07400020
AB - An experimental analysis of the effect of pulsed electric field (PEF) energy on the inactivation of Listeria monocytogenes was conducted using a custom-designed static chamber and a gel suspension medium for treatment. This allowed PEF energy to be delivered to the suspension under near isothermal conditions. The effects of variations in the number of pulses (5–50 pulses), electric field strength (15–30 kV/cm), temperature (0–60°C) and media bases (water and skim milk) on the inactivation of L. monocytogenes were examined. At temperatures less than 50°C a maximum of 1 log reduction was obtained for L. monocytogenes regardless of pulse number or electric field strength within the ranges examined. In skim milk no reduction occurred. At 50°C and 55°C synergy between PEF and thermal energy was observed. The experimental approach separated the contribution of PEF and thermal energy to total kill and thus allowed this synergy to be quantified. At 55°C the kill due to PEF energy increased to 4.5 logs with another 4.5 logs reduction attributable to thermal energy. It appears that under the conditions of this study PEF alone has a very limited effect on the reduction of L. monocytogenes. However, the addition of thermal energy not only contributed to the kill, but also increased the susceptibility of L. monocytogenes to PEF energy. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - ELECTRIC fields
KW - IMMUNITY
KW - MILK
KW - Gel
KW - Gellan gum
KW - Listeria
KW - Milk
KW - Pulsed electric field
KW - Static chamber
N1 - Accession Number: 11319278; Fleischman, Gregory J. 1; Email Address: gfleisch@cfsan.fda.gov Ravishankar, Sadhana 2 Balasubramaniam, V.M. 2; Affiliation: 1: US Food and Drug Administration, The National Center for Food Safety & Technology, 6502, South Archer Road, Summit-Argo, IL 60501, USA 2: The National Center for Food Safety and Technology, Illinois Institute of Technology, Moffett Campus, 6502 South Archer Road, Summit-Argo, IL 60501, USA; Source Info: Feb2004, Vol. 21 Issue 1, p91; Subject Term: LISTERIA monocytogenes; Subject Term: ELECTRIC fields; Subject Term: IMMUNITY; Subject Term: MILK; Author-Supplied Keyword: Gel; Author-Supplied Keyword: Gellan gum; Author-Supplied Keyword: Listeria; Author-Supplied Keyword: Milk; Author-Supplied Keyword: Pulsed electric field; Author-Supplied Keyword: Static chamber; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/S0740-0020(03)00015-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=11319278&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peden-Adams, M.M.
AU - Dudley, A.C.
AU - EuDaly, J.G.
AU - Allen, C.T
AU - Gilkeson, G.S.
AU - Keil, D.E.
T1 - Pyridostigmine Bromide (PYR) Alters Immune Function in B6C3F1 Mice.
JO - Immunopharmacology & Immunotoxicology
JF - Immunopharmacology & Immunotoxicology
Y1 - 2004/02//
VL - 26
IS - 1
M3 - Article
SP - 1
EP - 15
PB - Taylor & Francis Ltd
SN - 08923973
AB - Pyridostigmine bromide (PYR) is an anticholinesterase drug indicated for the treatment of myasthenia gravis and neuromuscular blockade reversal. It acts as a reversible cholinesterase inhibitor and was used as a pretreatment for soldiers during Operation Desert Storm to protect against possible nerve gas attacks. Since that time, PYR has been implicated as a possible causative agent contributing to Gulf War Illness. PYR's mechanism of action has been well-delineated with regards to its effects on the nervous system, yet little is known regarding potential effects on immunological function. To evaluate the effects of PYR on immunological function, adult female B6C3F1 mice were gavaged daily for 14 days with PYR (0, 1, 5, 10, or 20 mg/kg/day). Immune parameters assessed were lymphoproliferation, natural killer cell activity, the SRBC-specific antibody plaque-forming cell (PFC) response, thymus and spleen weight and cellularity, and thymic and splenic CD4/CD8 lymphocyte subpopulations. Exposure to PYR did not alter splenic and thymus weight or splenic cellularity. However, 20 mg PYR/kg/day decreased thymic cellularity with decreases in both CD4 + /CD8 + (20 mg/kg/day) and CD4 − /CD8 − (10 and 20 mg/kg/day) cell types. Functional immune assays indicated that lymphocyte proliferative responses and natural killer cell activity were normal; whereas exposure to PYR significantly decreased primary IgM antibody responses to a T-cell dependent antigen at the 1, 5, 10 and 20 mg/kg treatment levels for 14 days. This is the first study to examine the immunotoxicological effects of PYR and demonstrate that this compound selectively suppresses humoral antibody responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunopharmacology & Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PYRIDOSTIGMINE bromide
KW - IMMUNE response
KW - IMMUNOGLOBULIN M
KW - IMMUNOTOXICOLOGY
KW - PYRIDINIUM compounds
KW - BROMIDES
KW - Gulf War Illness
KW - IgM antibody responses
KW - Pyridostigmine bromide
N1 - Accession Number: 12523816; Peden-Adams, M.M. 1,2,3,4; Email Address: pedenada@musc.edu Dudley, A.C. 2 EuDaly, J.G. 2,4 Allen, C.T 2 Gilkeson, G.S. 1,4,5 Keil, D.E. 2,6; Affiliation: 1: Department of Rheumatology and Immunology 2: Department of Health Professions 3: Department of Pediatrics 4: Marine Biomedicine and Environmental Science Cetner, Medical University of South Carolina, Charleston, South Carolina, USA 5: Medical Research Service, Ralph Johnson VAMC, Charleston, South Carolina, USA 6: National Institute of Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Feb2004, Vol. 26 Issue 1, p1; Subject Term: PYRIDOSTIGMINE bromide; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULIN M; Subject Term: IMMUNOTOXICOLOGY; Subject Term: PYRIDINIUM compounds; Subject Term: BROMIDES; Author-Supplied Keyword: Gulf War Illness; Author-Supplied Keyword: IgM antibody responses; Author-Supplied Keyword: Pyridostigmine bromide; Number of Pages: 15p; Document Type: Article
L3 - 10.1081/IPH-120029939
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12523816&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Siegel, Sari
AU - Moy, Ernest
AU - Burstin, Helen
T1 - PERSPECTIVES Assessing the Nation's Progress Toward Elimination of Disparities in Health Care The National Healthcare Disparities Report.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2004/02//
VL - 19
IS - 2
M3 - Other
SP - 195
EP - 200
SN - 08848734
AB - The Agency for Healthcare Research and Quality submitted the first annual National Healthcare Disparities Report to Congress in December, 2003. This first report will provide a snapshot of the state of racial, ethnic, and socioeconomic disparities in access and quality of care in America. It examines disparities in the general population and within the Agency's priority populations. While focused on extant data, the first report will form the foundation for future versions, which examines causes of disparities and shape solutions to the problem. As patient advocates and agents of change, primary care physicians play a critical role in efforts to eliminate disparities in health care. Continuing participation by primary care physicians in the development and refinement of the National Healthcare Disparities Report is essential. J GEN INTERN MED 2004;19:195–200. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Quality control
KW - ETHNICITY
KW - SOCIAL status
KW - PRIMARY care (Medicine)
KW - UNITED States
KW - disparities
KW - ethnicity
KW - health care
KW - race
KW - socioeconomic status.
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 12378149; Siegel, Sari 1; Email Address: SSIEGEL@ahrq.gov Moy, Ernest 2 Burstin, Helen 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Department of Health and Human Services , Rockville, Md. 2: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Department of Health and Human Services (EM), Rockville, Md.; Source Info: Feb2004, Vol. 19 Issue 2, p195; Subject Term: MEDICAL care -- Quality control; Subject Term: ETHNICITY; Subject Term: SOCIAL status; Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Author-Supplied Keyword: disparities; Author-Supplied Keyword: ethnicity; Author-Supplied Keyword: health care; Author-Supplied Keyword: race; Author-Supplied Keyword: socioeconomic status.; Company/Entity: UNITED States. Agency for Healthcare Research & Quality; Number of Pages: 6p; Document Type: Other
L3 - 10.1111/j.1525-1497.2004.30221.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, John R.
T1 - It's Time for a Change, One Way or Another.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2004/02//
VL - 10
IS - 1
M3 - Article
SP - 3
EP - 5
SN - 10747583
AB - Focuses on the use of rollover protective structures (ROPS) for agricultural safety and health of tractor operators in the U.S. Impact of using ROPS on the provision of protection from tractor overturns; Reduction of death risks from operators falling from moving tractors; Continuance of educational activities designed to promote ROPS use to the farming community.
KW - Rollover protective structures (Machinery)
KW - Agricultural safety
KW - Farm tractors
KW - Farm risks
KW - United States
N1 - Accession Number: 12448203; Myers, John R. 1; Email Address: jrmyers@cdc.gov; Affiliations: 1: Health Statistician, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Feb2004, Vol. 10 Issue 1, p3; Subject Term: Rollover protective structures (Machinery); Subject Term: Agricultural safety; Subject Term: Farm tractors; Subject Term: Farm risks; Subject: United States; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vann, Willie F.
AU - Daines, Dayle A.
AU - Murkin, Andrew S.
AU - Tanner, Martin E.
AU - Chaffin, Donald O.
AU - Rubens, Craig E.
AU - Vionnet, Justine
AU - Silver, Richard P.
T1 - The NeuC Protein of Escherichia coli K1 Is a UDP N-Acetylglucosamine 2-Epimerase.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2004/02//
VL - 186
IS - 3
M3 - Article
SP - 706
EP - 712
SN - 00219193
AB - Discusses the determination of Escherichia coli strains which cause meningitis in neonates. Implication of the gene in sialic acid synthesis by allelic exchange; Restoration of capsule expression in the deletion strain; Similarity of the deduced amino acid sequence.
KW - ESCHERICHIA coli
KW - MENINGITIS
KW - NEWBORN infants
KW - GENES
KW - SIALIC acids
KW - ALLELES
N1 - Accession Number: 12333023; Vann, Willie F. 1; Email Address: wvann@helix.nih.gov Daines, Dayle A. 2 Murkin, Andrew S. 3 Tanner, Martin E. 3 Chaffin, Donald O. 4 Rubens, Craig E. 4 Vionnet, Justine 1 Silver, Richard P. 2; Affiliation: 1: Department of Microbiology and Immunology, University of Rochester Medical Center, New York 2: Laboratory of Bacterial Toxins, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland 3: Department of Chemistry, The University of British Columbia, Canada 4: Department of Pediatrics, University of Washington, Children's Hospital and Regional Medical Center, Washington; Source Info: Feb2004, Vol. 186 Issue 3, p706; Subject Term: ESCHERICHIA coli; Subject Term: MENINGITIS; Subject Term: NEWBORN infants; Subject Term: GENES; Subject Term: SIALIC acids; Subject Term: ALLELES; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 1 Diagram, 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1128/JB.186.3.706-712.2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12333023&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hong, Sung Ran
AU - Chong, Moo Sang
AU - Lee, Sang Bong
AU - Lee, Young Moo
AU - Song, Kang Won
AU - Park, Moon Hyang
AU - Hong, Sung Hwa
T1 - Biocompatibility and biodegradation of cross-linked gelatin/hyaluronic acid sponge in rat subcutaneous tissue.
JO - Journal of Biomaterials Science -- Polymer Edition
JF - Journal of Biomaterials Science -- Polymer Edition
Y1 - 2004/02//
VL - 15
IS - 2
M3 - Article
SP - 201
EP - 214
PB - Taylor & Francis Ltd
SN - 09205063
AB - A gelatin/hyaluronic acid (GH) sponge has been fabricated by freeze-drying and cross-linking. The GH sponge was insoluble when cross-linked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The morphologies of sponges were investigated using a field emission scanning electron microscope. The porosity of the GH sponge increased with hyaluronic acid content. The GH sponge was biodegradable, as evidenced by implantation in Wistar rat subcutaneous connective tissue. Fibroblasts infiltrated into the sponge matrix, and regenerated collagen in the matrix to a level of 25% by 15 days after surgery. The GH73 sponge induced an acute inflammatory response compared with the GH91 sponge. This inflammatory response could have been stimulated by the presence of hyaluronic acid up to Day 10, as it decreased afterwards. The C-reactive protein of blood samples also indicated the same result. The blood tests and histological results show that GH sponges have good biocompatibility and low antigenicity for tissue engineering scaffolds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GELATIN
KW - HYALURONIC acid
KW - SPONGES (Invertebrates)
KW - RATS
KW - PROTEINS
KW - FIBROBLASTS
KW - BIOCOMPATIBILITY
KW - BIODEGRADATION
KW - BLOOD TEST
KW - HYALURONIC ACID
KW - SPONGE
N1 - Accession Number: 12336452; Hong, Sung Ran Chong, Moo Sang 1 Lee, Sang Bong 1 Lee, Young Moo 1; Email Address: ymlee@hanyang.ac.kr Song, Kang Won 2 Park, Moon Hyang 2 Hong, Sung Hwa 3; Affiliation: 1: School of Chemical Engineering, College of Engineering, Hanyang University, Seongdong-ku, Seoul, 133-791, South Korea. 2: Department of Pathology, College of Medicine, Hanyang University, Seongdong-ku, Seoul, 133-791, South Korea. 3: Blood products division, Biologics Evaluation Department, Korea Food and Drug Administration, Seoul, 122-704, South Korea.; Source Info: Feb2004, Vol. 15 Issue 2, p201; Subject Term: GELATIN; Subject Term: HYALURONIC acid; Subject Term: SPONGES (Invertebrates); Subject Term: RATS; Subject Term: PROTEINS; Subject Term: FIBROBLASTS; Author-Supplied Keyword: BIOCOMPATIBILITY; Author-Supplied Keyword: BIODEGRADATION; Author-Supplied Keyword: BLOOD TEST; Author-Supplied Keyword: HYALURONIC ACID; Author-Supplied Keyword: SPONGE; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 14p; Document Type: Article
L3 - 10.1163/156856204322793584
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12336452&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sridhara, Rajeshwari
AU - Chen, Gang
AU - Chi, George Y.H.
AU - Griebel, Donna J.
T1 - Evaluation of Health-Related Quality-of-Life Measures in Oncology Drug Product Applications: Issues and Concerns#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2004/02//
VL - 14
IS - 1
M3 - Article
SP - 23
EP - 30
PB - Taylor & Francis Ltd
SN - 10543406
AB - Health-related quality-of-life outcomes as reported by patients are valuable data and ideally should be critical to evaluating clinical benefit. The unblinded or open-label designs commonly adapted in oncology trials have the potential to introduce selection bias, reporting bias, and analyses bias. In this paper, issues surrounding use of patient reported outcomes to evaluate oncology drug products, including definition of hypothesis, study design, analysis, and interpretation of patient reported outcome data, are reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITY of life
KW - HEALTH
KW - ONCOLOGY
KW - CLINICAL trials
KW - CLINICAL drug trials
KW - BIOPHARMACEUTICS
KW - HRQOL
KW - Oncology drug products
KW - Patient reported outcome
N1 - Accession Number: 12523831; Sridhara, Rajeshwari 1; Email Address: sridharar@cder.fda.gov Chen, Gang 2 Chi, George Y.H. 1 Griebel, Donna J. 3; Affiliation: 1: Division of Biometrics 1, HFD-710, Office of Biostatistics, The Food and Drug Administration, Rockville, Maryland, USA 2: Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey, USA 3: Division of Reproductive and Urologic Drug Products, Office of New Drugs, The Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2004, Vol. 14 Issue 1, p23; Subject Term: QUALITY of life; Subject Term: HEALTH; Subject Term: ONCOLOGY; Subject Term: CLINICAL trials; Subject Term: CLINICAL drug trials; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: HRQOL; Author-Supplied Keyword: Oncology drug products; Author-Supplied Keyword: Patient reported outcome; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1081/BIP-120028504
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tanofsky-Kraff, Marian
AU - Wilfley, Denise E.
AU - Morgan, Christina M.
AU - Yanovski, Susan Z.
AU - Marmarosh, Cheri
AU - Yanovski, Jack A.
T1 - Eating-Disordered Behaviors, Body Fat, and Psychopathology in Overweight and Normal-Weight Children.
JO - Journal of Consulting & Clinical Psychology
JF - Journal of Consulting & Clinical Psychology
Y1 - 2004/02//
VL - 72
IS - 1
M3 - Article
SP - 53
EP - 61
SN - 0022006X
AB - This study examined eating-disordered pathology in relation to psychopathology and adiposity in 162 non-treatment-seeking overweight (OW) and normal weight (NW) children, ages 6-13 years. Participants experienced objective or subjective binge eating (S/OBE; loss-of-control eating), objective over- eating (OO), or no episodes (NE). OW children experienced significantly higher eating-disordered cognitions and behaviors than NW children and more behavior problems than NW children: 9.3% endorsed S/OBEs, 20.4% reported OOs, and 70.4% reported NEs. OW children reported S/OBEs more frequently than did NW children (p = .01), but similar percentages endorsed OOs. SIOBE children experienced greater eating-disordered cognitions (ps from < .05 to < .01) and had higher body fat (p < .05) than OOs or NEs. OOs are common in childhood, but S/OBEs are more prevalent in OW children and associated with increased adiposity and eating-disordered cognitions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Consulting & Clinical Psychology is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EATING disorders
KW - PATHOLOGY
KW - PATHOLOGICAL psychology
KW - OBESITY
KW - COGNITION
KW - CHILDREN
N1 - Accession Number: 12316226; Tanofsky-Kraff, Marian 1 Wilfley, Denise E. 2 Morgan, Christina M. 3 Yanovski, Susan Z. 4 Marmarosh, Cheri 5 Yanovski, Jack A. 6; Email Address: jy15i@nih.gov; Affiliation: 1: Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development and Catholic University of America. 2: Washington University School of Medicine. 3: Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development and Universidade Federal de São Paulo, Brazil. 4: Unit on Growth and Obesity, Developmental Endocrinology Branch, NICHD, and Division of Digestive Diseases and Nutrition, National Institute of Child Health and Human Development and National Institute of Diabetes and Digestive and Kidney Diseases. 5: Department of Psychology, Catholic University of America. 6: Unit on Growth and Obesity, Developmental Endocrinology Branch, NICHD, National Institute of Child Health and Human Development and United States Public Health Service.; Source Info: Feb2004, Vol. 72 Issue 1, p53; Subject Term: EATING disorders; Subject Term: PATHOLOGY; Subject Term: PATHOLOGICAL psychology; Subject Term: OBESITY; Subject Term: COGNITION; Subject Term: CHILDREN; Number of Pages: 9p; Document Type: Article
L3 - 10.1037/0022-006X072.1.53
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waters, Thomas R.
T1 - National efforts to identify research issues related to prevention of work-related musculoskeletal disorders
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
Y1 - 2004/02//
VL - 14
IS - 1
M3 - Article
SP - 7
SN - 10506411
AB - Musculoskeletal disorders (MSDs), including low back and upper extremity disorders, represent one of the greatest work-related health concerns facing industrialized nations. Recently, two national groups were charged with developing research agendas aimed at increasing our knowledge of the prevention of these disorders. The first agenda, developed by the National Institute for Occupational Safety and Health''s (NIOSH) National Occupational Research Agenda (NORA) MSD team, was based on input from several hundred practitioners and safety and health experts representing industry, labor, and academia. The second agenda, developed by the National Research Council (NRC) and the Institute of Medicine''s (IOM) National Panel on Musculoskeletal Disorders and the Workplace, was based on input from leading researchers in the fields of medicine, information science, and ergonomics. This paper summarizes the findings of the two groups and compares the two research agendas. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electromyography & Kinesiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - RESEARCH
KW - DEVELOPED countries
KW - Low back pain
KW - Prevention
KW - Research gaps
KW - Upper extremity disorders
N1 - Accession Number: 12097038; Waters, Thomas R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, OH, 45226, USA; Source Info: Feb2004, Vol. 14 Issue 1, p7; Subject Term: MEDICAL care; Subject Term: RESEARCH; Subject Term: DEVELOPED countries; Author-Supplied Keyword: Low back pain; Author-Supplied Keyword: Prevention; Author-Supplied Keyword: Research gaps; Author-Supplied Keyword: Upper extremity disorders; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jelekin.2003.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Glew, R.S.
AU - VanderJagt, D.J.
AU - Huang, Y.-S.
AU - Chuang, L.-T.
AU - Bosse, R.
AU - Glew, R.H.
T1 - Nutritional analysis of the edible pit of Sclerocarya birrea in the Republic of Niger (daniya, Hausa)
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2004/02//
VL - 17
IS - 1
M3 - Article
SP - 99
SN - 08891575
AB - Wild plant foods in the Sahel region of West Africa play an important role in the diets of local residents. During periods of grain shortage, people in rural Niger increase their reliance on wild plant foods to supplement their diets. We report the partial nutrient content of the pit of the seed Sclerocarya birrea, a snack food eaten by children in rural Niger. The pit contained relatively large amounts of copper (24.8 μg/g dry wt), magnesium (4210 μg/g dry wt), and zinc (62.4 μg/g dry wt). The protein content of the pit was high (36.4% of dry wt); however, the protein fraction contained relatively low proportions of leucine, phenylalanine, lysine, and threonine. Fatty acids accounted for 47 mg/g dry wt of the pit, two-thirds of which was due to oleic acid. The essential fatty acid linoleic acid was present (24.5 mg/g dry wt), but the other essential fatty acid, α -linolenic acid, was absent. Such data are useful for health and nutrition program planning by governmental and non-governmental organizations in Niger. The consumption of daniya pits by just children highlights the need to better understand the cultural context of how wild plant foods are used in a particular local context. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EDIBLE wild plants
KW - DIET
KW - NIGER
KW - SAHEL
KW - Amino acids
KW - Daniya
KW - Famine food
KW - Fatty acids
KW - Minerals
KW - Niger
KW - Nutrients
KW - Sclerocarya birrea
N1 - Accession Number: 12238629; Glew, R.S. 1 VanderJagt, D.J. 2 Huang, Y.-S. 3 Chuang, L.-T. 3 Bosse, R. 4 Glew, R.H. 2; Email Address: rglew@salud.unm.edu; Affiliation: 1: Center for Advanced Study of International Development, Michigan State University, East Lansing, MI, USA 2: Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico, Albuquerque, NM 87131-5221, USA 3: Ross Products Division, Abbott Laboratories, Columbus, OH, USA 4: National Institute of Occupational Safety and Health (NIOSH), Cincinnati, OH, USA; Source Info: Feb2004, Vol. 17 Issue 1, p99; Subject Term: EDIBLE wild plants; Subject Term: DIET; Subject Term: NIGER; Subject Term: SAHEL; Author-Supplied Keyword: Amino acids; Author-Supplied Keyword: Daniya; Author-Supplied Keyword: Famine food; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Minerals; Author-Supplied Keyword: Niger; Author-Supplied Keyword: Nutrients; Author-Supplied Keyword: Sclerocarya birrea; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0889-1575(03)00101-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spencer, Steven E.
AU - Valentin-Bon, Iris E.
AU - Whaley, Kevin
AU - Jerse, Ann E.
T1 - Inhibition of Neisseria gonorrhoeae Genital Tract Infection by Leading-Candidate Topical Microbicides in a Mouse Model.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/02//2/1/2004
VL - 189
IS - 3
M3 - Article
SP - 410
EP - 419
SN - 00221899
AB - The development of effective vaginal microbicides is paramount in the fight against the spread of sexually transmitted infections. Preclinical testing of candidate microbicides for the prevention of gonorrhea has been seriously hindered by the lack of an animal model. We assessed the efficacy of 7 promising formulated agents—CarraGuard, Ushercell, [poly]sodium 4-styrene sulfonate (T-PSS), PRO 2000, ACIDFORM, cellulose acetate phthalate (CAP), and BufferGel—by use of a mouse model of Neisseria gonorrhoeae genital tract infection. Mice received test agent, relevant placebo, or no treatment, followed by intravaginal N. gonorrhoeae challenge. N. gonorrhoeae colonization was tested by vaginal culture. CarraGuard, Ushercell, and T-PSS demonstrated significant protection, compared with control agents and no treatment. PRO 2000, ACIDFORM, and CAP showed significant protection, compared with no treatment but not compared with respective control agents. Mice that received BufferGel were provided significant protection, compared with untreated control mice; no placebo was tested. The findings of the present study suggest that topical agents may effectively reduce N. gonorrhoeae infection and that further evaluation is warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Animal models in research
KW - Neisseria gonorrhoeae
KW - Genitalia
KW - Sexually transmitted diseases
KW - Gonorrhea -- Prevention
KW - Medical research
KW - Clinical medicine
N1 - Accession Number: 12083701; Spencer, Steven E. 1,2; Email Address: SSpencerMD@comcast.net; Valentin-Bon, Iris E. 3; Whaley, Kevin 4,5,6; Jerse, Ann E. 1; Email Address: ajerse@usuhs.mil; Affiliations: 1: Department of Microbiology and Immunology, Uniformed Services University, Bethesda; 2: Walter Reed Army Medical Center, Washington, DC; 3: United States Food and Drug Administration, Rockville; 4: Department of Biophysics, Johns Hopkins University; 5: ReProtect, Baltimore, Maryland; 6: Epicyte Pharmaceutical, San Diego, California; Issue Info: 2/1/2004, Vol. 189 Issue 3, p410; Thesaurus Term: DISEASES; Thesaurus Term: Animal models in research; Subject Term: Neisseria gonorrhoeae; Subject Term: Genitalia; Subject Term: Sexually transmitted diseases; Subject Term: Gonorrhea -- Prevention; Subject Term: Medical research; Subject Term: Clinical medicine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aletras, Anthony H.
AU - Freidlin, Raisa Z.
AU - Navon, Gil
AU - Arai, Andrew E.
T1 - AIR-SPAMM: alternative inversion recovery spatial modulation of magnetization for myocardial tagging
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
Y1 - 2004/02//
VL - 166
IS - 2
M3 - Article
SP - 236
SN - 10907807
AB - Alternate inversion recovery spatial modulation of magnetization (AIR-SPAMM) can be used either for doubling the number of tags for a given tagging encoding gradient strength or for improving tagging contrast ratio. AIR-SPAMM requires only a single acquisition and utilizes inversion pulses spaced throughout the gradient recalled echo (GRE) cine acquisition to “lock” the recovering magnetization at a desired level. The theory of AIR-SPAMM is presented along with simulations and results from phantoms. AIR-SPAMM can be used either for imaging systole as demonstrated by initial in vivo results or potentially for imaging the entire cardiac cycle in a slice-interleaved manner. [Copyright &y& Elsevier]
AB - Copyright of Journal of Magnetic Resonance is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIZATION
KW - HEART beat
KW - SPATIAL systems
KW - MAGNETICS
KW - Cardiac
KW - DENSE
KW - Function
KW - HARP
KW - Heart
KW - MRI
KW - SPAMM
KW - Tagging
N1 - Accession Number: 11886423; Aletras, Anthony H. 1; Email Address: Anthony_Aletras@nih.gov Freidlin, Raisa Z. 1,2 Navon, Gil 1,3 Arai, Andrew E. 1; Affiliation: 1: Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D416, MSC 1061, Bethesda, MD 20892-1061, USA 2: US Department of Health and Human Services, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA 3: School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel; Source Info: Feb2004, Vol. 166 Issue 2, p236; Subject Term: MAGNETIZATION; Subject Term: HEART beat; Subject Term: SPATIAL systems; Subject Term: MAGNETICS; Author-Supplied Keyword: Cardiac; Author-Supplied Keyword: DENSE; Author-Supplied Keyword: Function; Author-Supplied Keyword: HARP; Author-Supplied Keyword: Heart; Author-Supplied Keyword: MRI; Author-Supplied Keyword: SPAMM; Author-Supplied Keyword: Tagging; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jmr.2003.10.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106770684
T1 - Building comprehensive community care systems.
AU - Manderscheid RW
AU - Hutchings GP
Y1 - 2004/02//
N1 - Accession Number: 106770684. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9212352.
KW - Community Mental Health Services -- Standards -- United States
KW - Government Agencies
KW - Health and Welfare Planning
KW - Health Care Delivery -- United States
KW - Community-Institutional Relations
KW - Consumer Participation
KW - Health Services Accessibility
KW - Health Services Needs and Demand
KW - Mental Health Services -- Legislation and Jurisprudence -- United States
KW - Organizational Change
KW - Practice Guidelines
KW - Professional Practice, Evidence-Based
KW - Quality of Health Care
KW - United States
SP - 37
EP - 41
JO - Journal of Mental Health
JF - Journal of Mental Health
JA - J MENT HEALTH
VL - 13
IS - 1
CY - Oxfordshire,
PB - Routledge
AB - Comprehensive community systems of care are essential for successful transformation of mental health services in the US. This document outlines core principles that can guide development of such systems and proposes key actions steps to initiate the process.Declaration of interest: This paper was produced while Ms. Hutchings and I were employees of the US Government. Therefore, it is in the public domain and cannot be copyrighted. Rights are transferred to the extent possible.
SN - 0963-8237
AD - Center for Mental Health Services, SAMHSA HHS, Room 15c-04, 5600 Fishers Lane, Rockville, MD 20857; rmanders@samhsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taitt, C. R.
AU - Golden, J. P.
AU - Shubin, Y. S.
AU - Shriver-Lake, L. C.
AU - Sapsford, K. E.
AU - Rasooly, A.
AU - Ligler, F. S.
T1 - A Portable Array Biosensor for Detecting Multiple Analytes in Complex Samples.
JO - Microbial Ecology
JF - Microbial Ecology
Y1 - 2004/02//
VL - 47
IS - 2
M3 - Article
SP - 175
EP - 185
SN - 00953628
AB - The Multi-Analyte Array Biosensor (MAAB) has been developed at the Naval Research Laboratory (NRL) with the goal of simultaneously detecting and identifying multiple target agents in complex samples with minimal user manipulation. This paper will focus on recent improvements in the biochemical and engineering aspects of this instrument. These improvements have enabled the expansion of the repertoire of analytes detected to include Salmonella typhimurium and Listeria monocytogenes, and also expanded the different sample matrices tested. Furthermore, all components of the biochemical assays could be prepared well in advance of sample testing, resulting in a “plug-and-play” methodology. Simultaneous detection of three toxins (ricin, staphylococcal enterotoxin B, and cholera toxin) was demonstrated using a novel fluidics cube module that limits the number of manipulations to only the initial sample loading. This work demonstrates the utility of the MAAB for rapid analysis of complex samples with multianalyte capability, with a minimum of operator manipulations required for either sample preparation or final analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbial Ecology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - NAVAL research
KW - SALMONELLA typhimurium
KW - LISTERIA monocytogenes
KW - TOXINS
N1 - Accession Number: 16936060; Taitt, C. R. 1; Email Address: crtaitt@cbmse.nrl.navy.mil Golden, J. P. 1 Shubin, Y. S. 2 Shriver-Lake, L. C. 1 Sapsford, K. E. 3 Rasooly, A. 4 Ligler, F. S. 1; Affiliation: 1: Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348, USA 2: Geo-Centers, Inc., Suitland, MD, USA 3: George Mason University, Arlington, VA, USA 4: CFSAN, Food and Drug Administration, College Park, MD, USA; Source Info: Feb2004, Vol. 47 Issue 2, p175; Subject Term: BIOSENSORS; Subject Term: NAVAL research; Subject Term: SALMONELLA typhimurium; Subject Term: LISTERIA monocytogenes; Subject Term: TOXINS; Number of Pages: 11p; Illustrations: 3 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00248-003-1011-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brady, P. Jeffrey
AU - Olsen, Cara H.
AU - Trump, David H.
T1 - Self-Rated Health and Subsequent Health Care Use among Military Personnel Returning from International Deployments.
JO - Military Medicine
JF - Military Medicine
Y1 - 2004/02//
VL - 169
IS - 2
M3 - Article
SP - 128
EP - 133
PB - AMSUS
SN - 00264075
AB - Individual health status assessment upon completion of U.S. military deployments was standardized in 1999 with a brief health assessment questionnaire. This cohort study analyzed health status responses and their relationship to postdeployment health outcomes among 16,142 military personnel who completed a health questionnaire after a deployment ending in 1999. Respondents were Army and Air Force personnel returning from Europe or Southwest Asia. Fourteen percent documented at least one health concern and 1.8% had fair/poor self-rated health. In the 6 months after deployment, 1.4% were hospitalized, 25% made five or more outpatient visits, and 4% separated from military service. Deployers with fair/poor self-rated health were at a significantly increased risk for high use of outpatient services (risk ratio, men 1.8, women 1.7) but not for hospitalization or separation. Self-report of low health status or other health concerns may help identify deployers with higher health care needs after future deployments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH status indicators
KW - HEALTH risk assessment
KW - MILITARY personnel
KW - DEPLOYMENT (Military strategy)
KW - UNITED States
N1 - Accession Number: 12372163; Brady, P. Jeffrey 1,2 Olsen, Cara H. 3 Trump, David H. 3; Affiliation: 1: Army Medical Surveillance Activity, U.S. Army Center for Health Promotion and Preventive Medicine, Washington, DC 20307-5001 2: Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland 3: Department of Preventive Medicine and Biometrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799; Source Info: Feb2004, Vol. 169 Issue 2, p128; Subject Term: HEALTH status indicators; Subject Term: HEALTH risk assessment; Subject Term: MILITARY personnel; Subject Term: DEPLOYMENT (Military strategy); Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alayash, Abdu I.
T1 - OXYGEN THERAPEUTICS: CAN WE TAME HAEMOGLOBIN?
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2004/02//
VL - 3
IS - 2
M3 - Article
SP - 152
EP - 159
PB - Nature Publishing Group
SN - 14741776
AB - Chemically modified or genetically engineered haemoglobins (Hbs) developed as oxygen therapeutics (often termed "blood substitutes") are designed to correct oxygen deficit due to ischaemia in a variety of clinical settings. These modifications are intended to stabilize Hb outside its natural environment -- red blood cells -- in a functional tetrameric and/or polymeric form. Uncontrolled haem-mediated oxidative reactions of cell-free Hb and its reactions with various oxidant/antioxidant and cell signalling systems have emerged as an important pathway of toxicity. Current protective strategies designed to produce safe Hb-based products are focused on controlling or suppressing the "radical" nature of Hb while retaining its oxygen-carrying function. INSETS: Fluorocarbon emulsions as oxygen carriers;Role of the US FDA in regulating blood substitutes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMATOLOGIC agents
KW - BLOOD substitutes
KW - ISCHEMIA
KW - ANOXEMIA
KW - OXYGEN
KW - BLOOD cells
KW - BLOOD circulation disorders
N1 - Accession Number: 17996314; Alayash, Abdu I. 1; Email Address: alayash@cber.fda.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, National Institutes of Health Building 29,Room 112, Bethesda, Maryland 20892, USA; Source Info: Feb2004, Vol. 3 Issue 2, p152; Subject Term: HEMATOLOGIC agents; Subject Term: BLOOD substitutes; Subject Term: ISCHEMIA; Subject Term: ANOXEMIA; Subject Term: OXYGEN; Subject Term: BLOOD cells; Subject Term: BLOOD circulation disorders; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 10 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyer, Susan L. F.
AU - Huettel, Robin N.
AU - Liu, Xing Zhong
AU - Humber, Richard A.
AU - Juba, Jean
AU - Nitao, James K.
T1 - Activity of fungal culture filtrates against soybean cyst nematode and root-knot nematode egg hatch and juvenile motility.
JO - Nematology
JF - Nematology
Y1 - 2004/02//
VL - 6
IS - 1
M3 - Article
SP - 23
EP - 32
PB - Brill Academic Publishers
SN - 13885545
AB - Fungi were isolated from soybean cyst nematode (SCN, Heterodera glycines) eggs collected in China, and 253 fungal isolates were assayed for production of compounds active against SCN and root-knot nematode (RKN, Meloidogyne incognita). Fungal isolates were grown for 3 and 7 days in potato dextrose broth (PDB), the culture broths were sterile-filtered to remove fungal biomass, and the filtrates were placed into 24-well plates to test for effects on egg hatch and juvenile motility. Meloidogyne incognita egg hatch ranged from 2 to 121% of hatch in PDB controls and H. glycines hatch from 15 to 224%. Activities of filtrates harvested after 3 and 7 days were significantly correlated. Only four isolates produced filtrates that significantly inhibited juvenile motility of SCN, RKN or both nematodes. This study identified fungal isolates capable of producing compounds active against these nematodes, and demonstrated that there was a low correlation in activity against SCN and RKN. The active fungal isolates are candidates for studies on identification of potential nematicides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nematology is the property of Brill Academic Publishers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FUNGI
KW - SOYBEAN cyst nematode
KW - SOYBEAN -- Diseases & pests
KW - PLANT nematodes
KW - ROOT-knot
KW - ROOT-knot nematodes
KW - NATURAL products
KW - CHINA
KW - China
KW - fungi
KW - HETERODERA GLYCINES
KW - MELOIDOGYNE INCOGNITA
KW - natural products
KW - NATURAL PRODUCTS.
N1 - Accession Number: 13155488; Meyer, Susan L. F. 1; Email Address: meyerf@ba.ars.usda.gov Huettel, Robin N. 1,2 Liu, Xing Zhong 3 Humber, Richard A. 4 Juba, Jean 5 Nitao, James K. 1,6; Affiliation: 1: USDA, ARS Nematology Lab, Bldg 011A, Rm 165B, BARC-West, 10300 Baltimore Avenue, Beltsville, MD 20705-2350, USA 2: Alabama Agricultural Experiment Station, 105 Comer Hall, Auburn University, AL 36849-5403, USA 3: Systematic Mycology and Lichenology Laboratory, Institute of Microbiology, Chinese Academy of Sciences, P.O. Box 2714, Beijing 100080, China 4: USDA, ARS Plant Protection Research Unit, US Plant, Soil and Nutrition Laboratory, Tower Road, Ithaca, NY 14853-2901, USA 5: Fusarium Research Center, Department of Plant Pathology, 216 Buckhout Laboratory, Pennsylvania State University, University Park, PA 16802, USA 6: USDA Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: 2004, Vol. 6 Issue 1, p23; Subject Term: FUNGI; Subject Term: SOYBEAN cyst nematode; Subject Term: SOYBEAN -- Diseases & pests; Subject Term: PLANT nematodes; Subject Term: ROOT-knot; Subject Term: ROOT-knot nematodes; Subject Term: NATURAL products; Subject Term: CHINA; Author-Supplied Keyword: China; Author-Supplied Keyword: fungi; Author-Supplied Keyword: HETERODERA GLYCINES; Author-Supplied Keyword: MELOIDOGYNE INCOGNITA; Author-Supplied Keyword: natural products; Author-Supplied Keyword: NATURAL PRODUCTS.; NAICS/Industry Codes: 111110 Soybean Farming; Number of Pages: 10p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1163/156854104323072883
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gallauresi, BeverlY Albrecht
T1 - Watch those power connections!
JO - Nursing
JF - Nursing
Y1 - 2004/02//
VL - 34
IS - 2
M3 - Article
SP - 27
EP - 27
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article provides information on tackling electricity problems while using medical apparatus and equipment. Many electronic devices have similar connection ports that can be mistakenly connected to other devices. When using more than one medical device at a time, carefully observe all connections and outlets.
KW - ELECTRICITY
KW - MEDICAL equipment
KW - ELECTRIC power
KW - ELECTRIC apparatus & appliances
KW - ELECTRIC connectors
KW - MEDICAL supplies
N1 - Accession Number: 12074214; Gallauresi, BeverlY Albrecht 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md.; Source Info: Feb2004, Vol. 34 Issue 2, p27; Subject Term: ELECTRICITY; Subject Term: MEDICAL equipment; Subject Term: ELECTRIC power; Subject Term: ELECTRIC apparatus & appliances; Subject Term: ELECTRIC connectors; Subject Term: MEDICAL supplies; NAICS/Industry Codes: 335999 All Other Miscellaneous Electrical Equipment and Component Manufacturing; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; NAICS/Industry Codes: 416110 Electrical wiring and construction supplies merchant wholesalers; NAICS/Industry Codes: 335990 All other electrical equipment and component manufacturing; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 335313 Switchgear and Switchboard Apparatus Manufacturing; NAICS/Industry Codes: 335930 Wiring device manufacturing; NAICS/Industry Codes: 335931 Current-Carrying Wiring Device Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106710993
T1 - Device safety. Watch those power connections!
AU - Gallauresi BA
Y1 - 2004/02//
N1 - Accession Number: 106710993. Language: English. Entry Date: 20040312. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Failure
KW - Equipment Safety
KW - Power Sources
KW - Defibrillators
KW - Suction -- Equipment and Supplies
SP - 27
EP - 27
JO - Nursing
JF - Nursing
JA - NURSING
VL - 34
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 14964222.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taylor, Christine Lewis
T1 - Regulatory Frameworks for Functional Foods and Dietary Supplements.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2004/02//
VL - 62
IS - 2
M3 - Article
SP - 55
EP - 59
SN - 00296643
AB - An understanding of the legal and regulatory requirements for foods, including dietary supplements and so-called functional foods, helps to focus attention on the special challenges that exist, which range from safety determinations to claim substantiation and consumer understanding. This article provides an overview of the Food and Drug Administration's regulatory framework for these products; it also highlights issues that are emerging and will require consideration and dialog. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMER protection
KW - FOOD -- Safety measures
KW - DIETARY supplements
KW - DELEGATED legislation
KW - CONSUMER education
KW - FOOD industry
KW - UNITED States
KW - dietary supplements
KW - foods
KW - regulations
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 12412255; Taylor, Christine Lewis 1; Affiliation: 1: Director, Office of Nutritional Products, Labelling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, USA; Source Info: Feb2004, Vol. 62 Issue 2, p55; Subject Term: CONSUMER protection; Subject Term: FOOD -- Safety measures; Subject Term: DIETARY supplements; Subject Term: DELEGATED legislation; Subject Term: CONSUMER education; Subject Term: FOOD industry; Subject Term: UNITED States; Author-Supplied Keyword: dietary supplements; Author-Supplied Keyword: foods; Author-Supplied Keyword: regulations; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1301/nr.2004feb.55-59
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106767967
T1 - Regulatory frameworks for functional foods and dietary supplements.
AU - Taylor CL
Y1 - 2004/02//
N1 - Accession Number: 106767967. Language: English. Entry Date: 20040820. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Functional Food -- Legislation and Jurisprudence
KW - Dietary Supplementation -- Legislation and Jurisprudence
KW - United States Food and Drug Administration -- Legislation and Jurisprudence
KW - United States
KW - Food Security
KW - Food Labeling
KW - Product Labeling
SP - 55
EP - 59
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 62
IS - 2
PB - Oxford University Press / USA
SN - 0029-6643
AD - Director, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20704
U2 - PMID: 15080366.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zeidler, Patti C.
AU - Castranova, Vincent
T1 - Role of nitric oxide in pathological responses of the lung to exposure to environmental/occupational agents.
JO - Redox Report
JF - Redox Report
Y1 - 2004/02//
VL - 9
IS - 1
M3 - Article
SP - 7
EP - 18
PB - Taylor & Francis Ltd
SN - 13510002
AB - Conflicting evidence exists as to whether nitric oxide expresses damaging/inflammatory or antioxidant/anti-inflammatory properties. Data presented in this review indicate that in vitro or in vivo exposure to selected environmental or occupational agents, such as asbestos, silica, ozone or lipopolysaccharide, can result in up-regulation of inducible nitric oxide synthase by alveolar macrophages and pulmonary epithelial cells. In the case of silica exposure, evidence consistently supports a damaging/inflammatory role of nitric oxide and/or peroxynitrite in the pathogenesis of lung disease. Although conflicting data have been reported, the majority of published studies suggest that nitric oxide plays a damaging role in pulmonary injury resulting from exposure to ozone or asbestos. In contrast, most information supports an anti-inflammatory role of nitric oxide following exposure to lipopolysaccharide. Further investigation is required to elucidate fully the mechanisms involved in determining the role of nitric oxide in the initiation and progression of various pulmonary diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Redox Report is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITRIC oxide
KW - LUNGS
KW - PATHOLOGY
KW - ASBESTOS
KW - SILICA
KW - PULMONARY alveoli
KW - ALVEOLAR MACROPHAGES
KW - asbestos
KW - lipopolysaccharide
KW - LUNG PATHOLOGY
KW - NITRIC OXIDE
KW - OZONE
KW - pulmonary epithelial cells
KW - silica
N1 - Accession Number: 12513860; Zeidler, Patti C. 1,2 Castranova, Vincent 1,2; Email Address: vic1@cdc.gov; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University, West Virginia, USA 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: 2004, Vol. 9 Issue 1, p7; Subject Term: NITRIC oxide; Subject Term: LUNGS; Subject Term: PATHOLOGY; Subject Term: ASBESTOS; Subject Term: SILICA; Subject Term: PULMONARY alveoli; Author-Supplied Keyword: ALVEOLAR MACROPHAGES; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: lipopolysaccharide; Author-Supplied Keyword: LUNG PATHOLOGY; Author-Supplied Keyword: NITRIC OXIDE; Author-Supplied Keyword: OZONE; Author-Supplied Keyword: pulmonary epithelial cells; Author-Supplied Keyword: silica; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 12p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1179/135100004225003879
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12513860&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wassell, James T.
T1 - Statistics With Applications in Biology and Geology (Book).
JO - Technometrics
JF - Technometrics
Y1 - 2004/02//
VL - 46
IS - 1
M3 - Book Review
SP - 111
EP - 111
SN - 00401706
AB - Reviews the book "Statistics With Applications in Biology and Geology," by Preben Blaesild and Jørgen Granfeldt.
KW - STATISTICS
KW - NONFICTION
KW - BLAESILD, Preben
KW - GRANFELDT, Jorgen
KW - STATISTICS With Applications in Biology & Geology (Book)
N1 - Accession Number: 12349237; Wassell, James T. 1; Affiliation: 1: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention; Source Info: Feb2004, Vol. 46 Issue 1, p111; Subject Term: STATISTICS; Subject Term: NONFICTION; Reviews & Products: STATISTICS With Applications in Biology & Geology (Book); People: BLAESILD, Preben; People: GRANFELDT, Jorgen; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MacDonald, James
AU - French, John E.
AU - Gerson, Ronald J.
AU - Goodman, Jay
AU - Inoue, Tohru
AU - Jacobs, Abigail
AU - Kasper, Peter
AU - Keller, Douglas
AU - Lavin, Amy
AU - Long, Gerald
AU - McCullough, Bruce
AU - Sistare, Frank D.
AU - Storer, Richard
AU - van der Laan, Jan Willem
T1 - The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/02//
VL - 77
IS - 2
M3 - Article
SP - 188
EP - 194
PB - Oxford University Press / USA
SN - 10966080
AB - The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several genetically modified mouse assays for assessing the human carcinogenic potential of compounds. The data from this testing program have made an important contribution to the general understanding of how these models can be best applied in hazard identification; however, questions still exist regarding methodology and data interpretation. To address these issues, ILSI HESI hosted a February 2003 workshop on the Utility of Transgenic Assays for Risk Assessment. The purpose of this workshop was to reach an understanding of how data from genetically modified mouse models are viewed by different regulatory bodies in the pharmaceutical sector and, based on this understanding, to identify areas in which more experimental work may be needed to increase the utility of data derived from these assays. In the course of discussions, various data gaps related to model selection and protocol issues were identified. Based on the outcome of the workshop, various studies are proposed to provide data to improve the utility of currently available assays for cancer hazard identification and risk assessment purposes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Carcinogenicity testing
KW - Risk assessment
KW - Life sciences
KW - Genetics
KW - Environmental sciences
KW - Toxicology
KW - carcinogenicity
KW - genetically modified mice
KW - p53+/- knockout mouse
KW - regulatory perspective
KW - risk assessment
KW - Tg.rasH2 transgenic mouse
N1 - Accession Number: 20606034; MacDonald, James 1; French, John E. 2; Gerson, Ronald J. 3; Goodman, Jay 4; Inoue, Tohru 5; Jacobs, Abigail 6; Kasper, Peter 7; Keller, Douglas 8; Lavin, Amy 9; Email Address: alavin@ilsi.org; Long, Gerald 10; McCullough, Bruce 11; Sistare, Frank D. 6; Storer, Richard 12; van der Laan, Jan Willem 13; Affiliations: 1: Schering-Plough Research Institute, Kenilworth, New Jersey 07033; 2: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; 3: Endo Pharmaceuticals, Chadds Ford, Pennsylvania 19352; 4: Michigan State University, East Lansing, Michigan 48824; 5: National Institute of Health Sciences, Tokyo 158-8501, Japan; 6: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, Maryland 20857; 7: Federal Institute for Drugs and Medical Devices (BfArM), D-53175 Berlin, Germany; 8: Sanofi-Synthelabo Research, Malvern, Pennsylvania 19355; 9: ILSI Health and Environmental Sciences Institute, Washington, DC 20005; 10: Eli Lilly & Company, Greenfield, Indiana 46140; 11: Aventis Pharmaceuticals, Inc., Bridgewater, New Jersey 08807; 12: Merck Research Laboratories, West Point, Pennsylvania, 19486; 13: National Institute of Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands; Issue Info: Feb2004, Vol. 77 Issue 2, p188; Thesaurus Term: RESEARCH; Thesaurus Term: Carcinogenicity testing; Thesaurus Term: Risk assessment; Thesaurus Term: Life sciences; Thesaurus Term: Genetics; Thesaurus Term: Environmental sciences; Subject Term: Toxicology; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: genetically modified mice; Author-Supplied Keyword: p53+/- knockout mouse; Author-Supplied Keyword: regulatory perspective; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: Tg.rasH2 transgenic mouse; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1093/toxsci/kfh037
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yin, Xuejun J.
AU - Dong, Caroline C.
AU - Ma, Jane Y. C.
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Stanley, Charles F.
AU - Schafer, Rosana
AU - Ma, Joseph K. H.
T1 - Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/02//
VL - 77
IS - 2
M3 - Article
SP - 263
EP - 271
PB - Oxford University Press / USA
SN - 10966080
AB - Diesel exhaust particles (DEP) have been shown to alter pulmonary immune responses to bacterial infection. Exposure of rats to 100 mg/m3 DEP for 4 h was found to aggravate Listeria monocytogenes(Listeria) infection at 3 days postinfection, but the bacteria were largely cleared at 7 days postinfection due to the development of a strong T cell–mediated immunity. In the present study, we examined the effects of repeated DEP exposure at lower doses on pulmonary responses to bacterial infection. Brown Norway rats were exposed to DEP by inhalation at 20.62 ± 1.31 mg/m 3 for 4 h/day for 5 days, followed by intratracheal inoculation with 100,000 Listeria at 2 h after the last DEP exposure. DEP-exposed rats showed a significant increase in lung bacterial load at both 3 and 7 days postinfection. The repeated DEP exposure was shown to suppress both the innate, orchestrated by alveolar macrophages (AM), and T cell–mediated responses to Listeria. DEP inhibited AM production of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) &agr;, and IL-12 but enhanced Listeria-induced AM production of IL-10, which has been shown to prolong the survival of intracellular pathogens such as Listeria. DEP exposure also suppressed the development of bacteria-specific lymphocytes from lung-draining lymph nodes, as indicated by the decreased numbers of T lymphocytes and their CD4+ and CD8+ subsets. Furthermore, the DEP exposure markedly inhibited the Listeria-induced lymphocyte secretion of IL-2 at day 7, IL-10 at days 3 and 7, and interferon- (IFN-) &ggr; at days 3 to 10 postinfection when compared to air-exposed controls. These results show a sustained pattern of downregulation of T cell–mediated immune responses by repeated low-dose DEP exposure, which is different from the results of a single high-dose exposure where the acute effect of DEP aggravated bacteria infection but triggered a strong T cell–mediated immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Diesel motor exhaust gas
KW - Immune response
KW - Prokaryotes
KW - Gram-positive bacteria
KW - Toxicology
KW - Rats as laboratory animals
KW - Listeria monocytogenes
KW - alveolar macrophages
KW - cytokines
KW - diesel exhaust particles
KW - inhalation
KW - lymphocytes
N1 - Accession Number: 20606041; Yin, Xuejun J. 1; Dong, Caroline C. 1; Ma, Jane Y. C. 2; Antonini, James M. 2; Roberts, Jenny R. 2; Stanley, Charles F. 3; Schafer, Rosana 4; Ma, Joseph K. H. 1; Email Address: jma@hsc.wvu.edu; Affiliations: 1: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 3: Mechanical and Aerospace Engineering Department, West Virginia University, Morgantown, West Virginia 26506; 4: School of Medicine, West Virginia University, Morgantown, West Virginia 26506; Issue Info: Feb2004, Vol. 77 Issue 2, p263; Thesaurus Term: RESEARCH; Thesaurus Term: Diesel motor exhaust gas; Thesaurus Term: Immune response; Thesaurus Term: Prokaryotes; Thesaurus Term: Gram-positive bacteria; Subject Term: Toxicology; Subject Term: Rats as laboratory animals; Subject Term: Listeria monocytogenes; Author-Supplied Keyword: alveolar macrophages; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: inhalation; Author-Supplied Keyword: lymphocytes; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfh035
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scofield, Terry L.
AU - Miller, John P.
AU - Storry, Jill R.
AU - Rios, Maria
AU - Reid, Marion E.
T1 - Evidence that Hy– RBCs express weak Joa antigen.
JO - Transfusion
JF - Transfusion
Y1 - 2004/02//
VL - 44
IS - 2
M3 - Article
SP - 170
EP - 172
PB - Wiley-Blackwell
SN - 00411132
AB - RBCs of the Hy– phenotype have, in the past, been typed as Gy(a+w), Hy–, Jo(a–), and RBCs with the Jo(a–) phenotype type Gy(a+), Hy+w, and Jo(a–). Anti-Hy and anti-Joa are difficult to identify mainly because appropriate reagent RBCs are poorly characterized. Historically, anti-Joa has not reacted with RBCs with either phenotype. This report describes a case of an anti-Joa that shows Hy– RBCs express some Joa antigen, albeit weakly. Anti-Joa was identified in a serum sample of a 71-year-old woman. The antibody reacted 1+ to 2+ by the IAT with all untreated and ficin-treated panel RBCs and did not react with Gy(a–) RBCs and Jo(a–) RBCs. Unexpectedly, the serum sample reacted weakly with six of eight RBC samples with the Hy– phenotype. The anti-Joa was adsorbed onto and eluted from Hy– RBCs, indicating the presence of weak Joa antigen. The patient's RBCs typed Gy(a+), Hy+, Jo(a–). DNA studies using PCR-RFLP analysis showed the patient to be homozygous for the JO allele, which is consistent with the serologically determined Jo(a–) status. The DNA and serologic evidence of this case show that Hy– RBCs may express low levels of Joa antigen, which contradicts previously published data concerning the Joa type of Hy– RBCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - ERYTHROCYTES
KW - PHENOTYPE
KW - ANTIGENIC determinants
KW - BLOOD
KW - CELLS
N1 - Accession Number: 12255585; Scofield, Terry L. 1 Miller, John P. 1 Storry, Jill R. 1 Rios, Maria 1 Reid, Marion E. 1; Affiliation: 1: American Red Cross-North Central Blood Services, St. Paul, Minnesota; the Immunohematology Laboratory, New York Blood Center; Skåne Blood Center, University Hospital, Lund, Sweden; and the Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland; Source Info: Feb2004, Vol. 44 Issue 2, p170; Subject Term: ANTIGENS; Subject Term: ERYTHROCYTES; Subject Term: PHENOTYPE; Subject Term: ANTIGENIC determinants; Subject Term: BLOOD; Subject Term: CELLS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/j.1537-2995.2004.00627.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldsmith, J. C.
AU - Eller, N.
AU - Mikolajczyk, M.
AU - Manischewitz, J.
AU - Golding, H.
AU - Scott, D. E.
T1 - ORIGINAL PAPER Intravenous immunoglobulin products contain neutralizing antibodies to vaccinia.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2004/02//
VL - 86
IS - 2
M3 - Article
SP - 125
EP - 129
PB - Wiley-Blackwell
SN - 00429007
AB - Individuals with primary or secondary immune-deficiency diseases may be at risk for vaccinia infection if widespread smallpox-immunization programmes are implemented in the United States of America (USA) for bioterrorism preparedness. The objective of this study was to determine whether commercial immune globulin (intravenous, human) products contain biologically active antibodies to vaccinia that have the potential to protect people, with immune deficiencies, from complications of vaccinia. Eight currently United States (US)-licensed and two European intravenous immunoglobulin (IVIG) products were tested in a vaccinia plaque-reduction neutralization assay. The in vivo activity of five of these lots was assessed in severely immune-deficient mice. All tested products contained neutralizing anti-vaccinia activity, in vitro and in vivo. The use of IVIG by individuals with inherited or acquired humoral immune deficiencies may provide some protection if they are inadvertently exposed to vaccinia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - IMMUNODEFICIENCY
KW - IMMUNOLOGIC diseases
KW - VACCINIA
KW - GLOBULINS
KW - SMALLPOX -- Vaccination
KW - anti-vaccinia virus antibodies
KW - human)
KW - immune globulin (intravenous
KW - primary immune deficiency
KW - smallpox vaccination
N1 - Accession Number: 12540033; Goldsmith, J. C. 1; Email Address: jgoldsmith@primaryimmune.org Eller, N. 2 Mikolajczyk, M. 2 Manischewitz, J. 2 Golding, H. 2 Scott, D. E. 2; Affiliation: 1: Immune Deficiency Foundation, Towson, MD, USA 2: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD USA; Source Info: Feb2004, Vol. 86 Issue 2, p125; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNODEFICIENCY; Subject Term: IMMUNOLOGIC diseases; Subject Term: VACCINIA; Subject Term: GLOBULINS; Subject Term: SMALLPOX -- Vaccination; Author-Supplied Keyword: anti-vaccinia virus antibodies; Author-Supplied Keyword: human); Author-Supplied Keyword: immune globulin (intravenous; Author-Supplied Keyword: primary immune deficiency; Author-Supplied Keyword: smallpox vaccination; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.0042-9007.2004.00397.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-10283-001
AN - 2004-10283-001
AU - Levkoff, Sue E.
AU - Chen, Hongtu
AU - Coakley, Eugenie
AU - Herr, Elizabeth C. McDonel
AU - Oslin, David W.
AU - Katz, Ira
AU - Bartels, Stephen J.
AU - Maxwell, James
AU - Olsen, Edwin
AU - Miles, Keith M.
AU - Costantino, Giuseppe
AU - Ware, James H.
T1 - Design and Sample Characteristics of the PRISM-E Multisite Randomized Trial to Improve Behavioral Health Care for the Elderly.
JF - Journal of Aging and Health
JO - Journal of Aging and Health
JA - J Aging Health
Y1 - 2004/02//
VL - 16
IS - 1
SP - 3
EP - 27
CY - US
PB - Sage Publications
SN - 0898-2643
SN - 1552-6887
N1 - Accession Number: 2004-10283-001. PMID: 14979308 Partial author list: First Author & Affiliation: Levkoff, Sue E.; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, US. Release Date: 20040712. Correction Date: 20111107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Anxiety; At Risk Populations; Geriatric Patients; Major Depression. Classification: Psychological Disorders (3210); Gerontology (2860). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 25. Issue Publication Date: Feb, 2004.
AB - Objective: To describe the design of the Primary Care Research in Substance Abuse and Mental Health for Elderly (PRISM-E) study and baseline characteristics of the randomized primary care patients with mental health problems and at-risk alcohol use. Method: Adults aged 65 and older were screened at primary care clinics from 10 study sites throughout the United States. Those diagnosed for depression, anxiety, and/or at-risk alcohol consumption were randomized to either integrated or enhanced referral care. Results: Of the 23,828 participants, 14% had a positive assessment for depressive and/or anxiety disorders, and 6% had at-risk alcohol consumption diagnoses. Among patients with mental health diagnoses, there was a higher preponderance of younger ages, women, and ethnic minorities. Among patients with at-risk drinking, there was a higher preponderance of younger ages, Whites, and men. Discussion: These findings indicate the need for screening in primary care and for engaging older adults in treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Primary Care Research in Substance Abuse and Mental Health for Elderly
KW - alcohol abuse
KW - behavioral health care
KW - elderly
KW - at risk population
KW - primary care
KW - mental disorder
KW - 2004
KW - Alcohol Abuse
KW - Anxiety
KW - At Risk Populations
KW - Geriatric Patients
KW - Major Depression
KW - 2004
DO - 10.1177/0898264303260390
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11699-001
AN - 2004-11699-001
AU - Gulbinat, Walter
AU - Manderscheid, Ron
AU - Baingana, Florence
AU - Jenkins, Rachel
AU - Khandelwal, Sudhir
AU - Levav, Itzhak
AU - Mak, F. Lieh
AU - Mayeya, John
AU - Minoletti, Albert
AU - Mubbashar, Malik H.
AU - Murthy, R. Srinivasa
AU - Deva, M. Parameshvara
AU - Schilder, Klaas
AU - Tomov, Toma
AU - Baba, Aliko
AU - Townsend, Clare
AU - Whiteford, Harvey
T1 - The International Consortium on Mental Health Policy and Services: Objectives, design and project implementation.
JF - International Review of Psychiatry
JO - International Review of Psychiatry
JA - Int Rev Psychiatry
Y1 - 2004/02//Feb-May, 2004
VL - 16
IS - 1-2
SP - 5
EP - 17
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0261
SN - 1369-1627
AD - Gulbinat, Walter, Global Network for Research in Mental and Neurological Health, Lichtenstein, Germany
N1 - Accession Number: 2004-11699-001. PMID: 15276933 Partial author list: First Author & Affiliation: Gulbinat, Walter; Global Network for Research in Mental and Neurological Health, Lichtenstein, Germany. Other Publishers: Informa Healthcare. Release Date: 20040503. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Government Policy Making; Mental Health Services; Program Development; Health Care Policy. Minor Descriptor: Developed Countries; Developing Countries. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Bulgaria; Chile; Egypt; Georgia; India; Iran; Lithuania; Malaysia; Nepal; Philippines; Pakistan; Thailand; Trinidad and Tobago; Uganda; Ukraine; Zambia. References Available: Y. Page Count: 13. Issue Publication Date: Feb-May, 2004.
AB - The concept of the burden of disease, introduced and estimated for a broad range of diseases in the World Bank report of 1993 illustrated that mental and neurological disorders not only entail a higher burden than cancer, but are responsible, in developed and developing countries, for more than 15% of the total burden of all diseases. In most developing countries the treatment gap for mental and neurological disorders is still unacceptably high. To address this problem, an international network of collaborating institutions in low-income countries has been set up. The establishment and the achievements of this network--the International Consortium on Mental Health Policy and Services--are reported. Over a two-year period, the network produced the key elements of a national mental health policy; provided tools and methods for assessing a country's current mental health status established a global network of expertise, i.e., institutions and experts, for use by countries wishing to reform their mental health policy, services and care; and generated guidelines and examples for upgrading mental health policy with due regard to the existing mental health delivery system and demographic, cultural and economic factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health policy
KW - mental health services
KW - disease burden
KW - International Consortium on Mental Health Policy
KW - objectives
KW - project implementation
KW - developed countries
KW - developing countries
KW - 2004
KW - Government Policy Making
KW - Mental Health Services
KW - Program Development
KW - Health Care Policy
KW - Developed Countries
KW - Developing Countries
KW - 2004
DO - 10.1080/09540260310001635050
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11699-001&site=ehost-live&scope=site
UR - walter@gulbinat.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11699-002
AN - 2004-11699-002
AU - Townsend, Clare
AU - Whiteford, Harvey
AU - Baingana, Florence
AU - Gulbinat, Walter
AU - Jenkins, Rachel
AU - Baba, Aliko
AU - Mak, F. Lieh
AU - Manderscheid, Ron
AU - Mayeya, John
AU - Minoletti, Albert
AU - Mubbashar, Malik H.
AU - Khandelwal, Sudhir
AU - Schilder, Klaas
AU - Tomov, Toma
AU - Deva, M. Parameshvara
T1 - The Mental Health Policy Template: Domains and elements for mental health policy formulation.
JF - International Review of Psychiatry
JO - International Review of Psychiatry
JA - Int Rev Psychiatry
Y1 - 2004/02//Feb-May, 2004
VL - 16
IS - 1-2
SP - 18
EP - 23
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0261
SN - 1369-1627
AD - Whiteford, Harvey, Department of Psychiatry, University of Queensland, Brisbane, QLD, Australia
N1 - Accession Number: 2004-11699-002. PMID: 15276934 Partial author list: First Author & Affiliation: Townsend, Clare; Queensland Centre for Mental Health Research, Wacol, QLD, Australia. Other Publishers: Informa Healthcare. Release Date: 20040503. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Government Policy Making; Mental Disorders; Mental Health; Mental Health Services; Health Care Policy. Minor Descriptor: Countries. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Chile; China; Czech Republic; India; Lithuania; Pakistan; Zambia. Methodology: Empirical Study. References Available: Y. Page Count: 6. Issue Publication Date: Feb-May, 2004.
AB - Mental disorders are a major and rising cause of disease burden in all countries. Even when resources are available, many countries do not have the policy and planning frameworks in place to identify and deliver effective interventions. The World Health Organization (WHO) and the World Bank have emphasized the need for ready access to the basic tools for mental health policy formulation, implementation and sustained development. The Analytical Studies on Mental Health Policy and Service Project, undertaken in 1999-2001 by the International Consortium for Mental Health Services and funded by the Global Forum for Health Research aims to address this need through the development of a template for mental health policy formulation. A mental health policy template has been developed based on an inventory of the key elements of a successful mental health policy. The Mental Health Policy Template has been revised and its applicability will be tested in a number of developing countries during 2001-2002. The Mental Health Policy Template and the work of the Consortium for Mental Health Services will be presented and the future role of the template in mental health policy development and reform in developing countries will be discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental disorders
KW - disease burden
KW - mental health policy formulation
KW - mental health services
KW - countries
KW - 2004
KW - Government Policy Making
KW - Mental Disorders
KW - Mental Health
KW - Mental Health Services
KW - Health Care Policy
KW - Countries
KW - 2004
DO - 10.1080/09540260310001635069
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11699-002&site=ehost-live&scope=site
UR - h.whiteford@uq.edu.au
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11699-003
AN - 2004-11699-003
AU - Schilder, Klaas
AU - Tomov, Toma
AU - Mladenova, M.
AU - Mayeya, John
AU - Jenkins, Rachel
AU - Gulbinat, Walter
AU - Manderscheid, Ron
AU - Baingana, Florence
AU - Whiteford, Harvey
AU - Khandelval, Sudhir
AU - Minoletti, Alberto
AU - Mubbashar, Malik H.
AU - Murthy, R. Srinivasa
AU - Deva, M. Parameshvara
AU - Baba, Aliko
AU - Townsend, Clare
AU - Sakuta, T.
T1 - The appropriateness and use of focus group methodology across international mental health communities.
JF - International Review of Psychiatry
JO - International Review of Psychiatry
JA - Int Rev Psychiatry
Y1 - 2004/02//Feb-May, 2004
VL - 16
IS - 1-2
SP - 24
EP - 30
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0261
SN - 1369-1627
AD - Schilder, Klaas, PAR 45-47, P.O. Box 616, 6200 MD, Maastricht, Netherlands
N1 - Accession Number: 2004-11699-003. PMID: 15276935 Partial author list: First Author & Affiliation: Schilder, Klaas; Consortium Center for Public Mental Health, Maastricht, Netherlands. Other Publishers: Informa Healthcare. Release Date: 20040503. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Cross Cultural Psychology; Data Collection; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: Bulgaria; Zambia. Methodology: Empirical Study; Interview; Focus Group; Qualitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb-May, 2004.
AB - The ability to interpret collected data across international mental health communities often proves to be difficult. The following paper reports on the use and appropriateness of focus group methodology in helping to clarify issues that could help substantiate data collection and comparison across different cultures and regions. Field tests of the focus group methodology were undertaken in different regions and this paper describes an overview of the final field test in Sofia, Bulgaria. The findings and experiences with utilizing this methodology were incorporated in subsequent data collections. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - focus group methodology
KW - international mental health communities
KW - data collection
KW - 2004
KW - Communities
KW - Cross Cultural Psychology
KW - Data Collection
KW - Mental Health
KW - 2004
DO - 10.1080/09540260310001635078
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11699-003&site=ehost-live&scope=site
UR - kschilder@ccpmh.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11699-004
AN - 2004-11699-004
AU - Jenkins, Rachel
AU - Gulbinat, Walter
AU - Manderscheid, Ron
AU - Baingana, Florence
AU - Whiteford, Harvey
AU - Khandelwal, Sudhir
AU - Minoletti, Alberto
AU - Mubbashar, Malik H.
AU - Murthy, R. Srinivasa
AU - Deva, M. Parameshvara
AU - Mak, F. Lieh
AU - Baba, Aliko
AU - Townsend, Clare
AU - Harrison, Marc
AU - Mohit, Ahmed
T1 - The Mental Health Country Profile: Background, design and use of a systematic method of appraisal.
JF - International Review of Psychiatry
JO - International Review of Psychiatry
JA - Int Rev Psychiatry
Y1 - 2004/02//Feb-May, 2004
VL - 16
IS - 1-2
SP - 31
EP - 47
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0261
SN - 1369-1627
AD - Jenkins, Rachel, Institute of Psychiatry, King's College London, London, United Kingdom, SE5 8AF
N1 - Accession Number: 2004-11699-004. PMID: 15276936 Partial author list: First Author & Affiliation: Jenkins, Rachel; Institute of Psychiatry, King's College London, London School of Hygiene & Tropical Medicine, London, United Kingdom. Other Publishers: Informa Healthcare. Release Date: 20040503. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Countries; Government Policy Making; Mental Health Services; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Azerbaijan; Bulgaria; Chile; Egypt; Georgia; India; Kenya; Kyrgyzstan; Lithuania; Malaysia; Nepal; Pakistan; Thailand; Uganda; Zambia. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Feb-May, 2004.
AB - This article describes the construction and use of a systematic structured method of mental health country situation appraisal, in order to help meet the need for conceptual tools to assist planners and policy makers develop and audit policy and implementation strategies. The tool encompasses the key domains of context, needs, resources, provisions and outcomes, and provides a framework for synthesizing key qualitative and quantitative information, flagging up gaps in knowledge, and for reviewing existing policies. It serves as an enabling tool to alert and inform policy makers, professionals and other key stakeholders about important issues which need to be considered in mental health policy development. It provides detailed country specific information in a systematic format, to facilitate global sharing of experiences of mental health reform and strategies between policy makers and other stakeholders. Lastly, it is designed to be a capacity building tool for local stakeholders to enhance situation appraisal, and multisectorial policy development and implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - country profile
KW - systematic structured method
KW - mental health country situation appraisal
KW - policy implementation
KW - 2004
KW - Countries
KW - Government Policy Making
KW - Mental Health Services
KW - Health Care Policy
KW - 2004
DO - 10.1080/09540260310001635087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11699-004&site=ehost-live&scope=site
UR - r.jenkins@iop.kcl.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11240-005
AN - 2004-11240-005
AU - Manderscheid, Ronald W.
AU - Hutchings, Gail P.
T1 - Building comprehensive community care systems.
JF - Journal of Mental Health
JO - Journal of Mental Health
JA - J Ment Health
Y1 - 2004/02//
VL - 13
IS - 1
SP - 37
EP - 41
CY - United Kingdom
PB - Taylor & Francis
SN - 0963-8237
SN - 1360-0567
AD - Manderscheid, Ronald W., Center for Mental Health Services, SAMHSA HHS, Room 15c-04, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-11240-005. Partial author list: First Author & Affiliation: Manderscheid, Ronald W.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20040322. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Page Count: 5. Issue Publication Date: Feb, 2004.
AB - Comprehensive community systems of care are essential for successful transformation of mental health services in the US. This document outlines core principles that can guide development of such systems and proposes key actions steps to initiate the process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community care systems
KW - mental health services
KW - 2004
KW - Community Mental Health Services
KW - 2004
DO - 10.1080/09638230410001654521
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11240-005&site=ehost-live&scope=site
UR - rmanders@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11548-005
AN - 2004-11548-005
AU - Spector, William D.
AU - Cohen, Joel W.
AU - Pesis-Katz, Irena
T1 - Home Care Before and After the Balanced Budget Act of 1997: Shifts in Financing and Services.
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2004/02//
VL - 44
IS - 1
SP - 39
EP - 47
CY - US
PB - Gerontological Society of America
SN - 0016-9013
SN - 1758-5341
AD - Spector, William D., Agency for Healthcare Research and Quality, 540 Gaither Road, Roclcville, MD, US, 20850
N1 - Accession Number: 2004-11548-005. PMID: 14978319 Partial author list: First Author & Affiliation: Spector, William D.; Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20041206. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Budgets; Health Care Costs; Home Care. Classification: Home Care & Hospice (3375). Population: Human (10). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2004.
AB - Purpose: This article describes the pattern of change in home-care use and expenditures, the distribution of payments by source, and the mix of skilled versus nonskilled services before and after 1996. Design and Methods: The analysis is based on tabulations of the 1987 National Medical Expenditure Survey and the 1996, 1998, and 1999 Medical Expenditure Panel Surveys. Estimates are weighted to represent the U.S. civilian noninstitutionalized population. Results: After increasing dramatically between 1987 and 1996, formal home-care use and expenditures fell between 1996 and 1999. The decline was largely due to a decrease in funding under Medicare, which coincided with changes initiated in the Balanced Budget Act of 1997 (BBA). Declines in total spending were attenuated by increases in expenditures under state and local programs. After the BBA, fewer skilled services were provided to the elderly population and more unskilled services were provided to the nonelderly population. Implications: These findings highlight the increasing role of state governments in funding home care after the BBA. However, more recent pressure on state budgets and the institution of prospective payment under Medicare for home care may alter these trends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - home care
KW - Balanced Budget Act
KW - payment patterns
KW - health care expenditures
KW - Medicare
KW - Medicaid
KW - 2004
KW - Budgets
KW - Health Care Costs
KW - Home Care
KW - 2004
DO - 10.1093/geront/44.1.39
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11548-005&site=ehost-live&scope=site
UR - wspector@AHRQ.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12877-005
AN - 2004-12877-005
AU - Conners, Nicola A.
AU - Bradley, Robert H.
AU - Mansell, Leanne Whiteside
AU - Liu, Jeffrey Y.
AU - Roberts, Tracy J.
AU - Burgdorf, Ken
AU - Herrell, James M.
T1 - Children of Mothers with Serious Substance Abuse Problems: An Accumulation of Risks.
JF - The American Journal of Drug and Alcohol Abuse
JO - The American Journal of Drug and Alcohol Abuse
JA - Am J Drug Alcohol Abuse
Y1 - 2004/02//
VL - 30
IS - 1
SP - 85
EP - 100
CY - United Kingdom
PB - Taylor & Francis
SN - 0095-2990
SN - 1097-9891
AD - Conners, Nicola A., Department of Pediatrics, University of Arkansas for Medical Sciences, AR, US
N1 - Accession Number: 2004-12877-005. PMID: 15083555 Partial author list: First Author & Affiliation: Conners, Nicola A.; Department of Pediatrics, University of Arkansas for Medical Sciences, AR, US. Other Publishers: Informa Healthcare. Release Date: 20040503. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Drug Abuse; Drug Rehabilitation; Mothers; Risk Factors. Minor Descriptor: Experiences (Events); Offspring. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). Tests & Measures: Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Feb, 2004.
AB - This study examines the life circumstances and experiences of 4,084 children affected by maternal addiction to alcohol or other drugs. The paper will address the characteristics of their caregivers, the multiple risk factors faced by these children, their health and development, and their school performance. Data were collected from mothers at intake into 50 publicly funded residential substance abuse treatment programs for pregnant and parenting women. Findings from this study suggest that children whose mothers abuse alcohol or other drugs confront a high level of risk and are at increased vulnerability for physical, academic, and social-emotional problems. Children affected by maternal addiction are in need of long-term supportive services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal alcohol addiction
KW - maternal drug addiction
KW - children's experiences
KW - life circumstances
KW - 2004
KW - At Risk Populations
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Mothers
KW - Risk Factors
KW - Experiences (Events)
KW - Offspring
KW - 2004
DO - 10.1081/ADA-120029867
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12877-005&site=ehost-live&scope=site
UR - connersnicolaa@uams.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2003-11055-005
AN - 2003-11055-005
AU - Eggerth, Donald E.
T1 - Applying the Bradley-Terry-Luce method to P-E fit.
JF - Journal of Vocational Behavior
JO - Journal of Vocational Behavior
JA - J Vocat Behav
Y1 - 2004/02//
VL - 64
IS - 1
SP - 92
EP - 107
CY - Netherlands
PB - Elsevier Science
SN - 0001-8791
SN - 1095-9084
AD - Eggerth, Donald E., Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2003-11055-005. Partial author list: First Author & Affiliation: Eggerth, Donald E.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20040126. Correction Date: 20160915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Goodness of Fit; Job Satisfaction; Mathematical Modeling; Occupational Adjustment; Person Environment Fit. Minor Descriptor: Theories. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Minnesota Importance Questionnaire DOI: 10.1037/t07495-000. Methodology: Empirical Study. References Available: Y. Page Count: 16. Issue Publication Date: Feb, 2004.
AB - This study attempted to increase the size of the correlation between person-environment (P-E) fit and job satisfaction by rescaling the instrumentation of the Theory of Work Adjustment using the Bradley-Terry-Luce method and a probability-based fit index. This approach worked as well as, but failed to outperform, the currently used correlation-based fit index. However, a probability-based fit index offers the advantage of being intuitively easier to understand than a correlation-based index. The very high correlation between the correlation-based fit index and the probability-based fit index suggests that both assess the same construct. It is argued that, considering the restriction of range common to all assessments of job satisfaction, the correlation between fit index and job satisfaction may not represent an upper limit, but rather a lower bound of the relationship between P-E fit and job satisfaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - person-environment fit
KW - job satisfaction
KW - theory of work adjustment
KW - Bradley-Terry-Luce method
KW - 2004
KW - Goodness of Fit
KW - Job Satisfaction
KW - Mathematical Modeling
KW - Occupational Adjustment
KW - Person Environment Fit
KW - Theories
KW - 2004
DO - 10.1016/S0001-8791(03)00048-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2003-11055-005&site=ehost-live&scope=site
UR - deggerth@cdc.gov.
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13628-002
AN - 2004-13628-002
AU - Clark, Pamela I.
AU - Gardiner, Phillip S.
AU - Djordjevic, Mirjana V.
AU - Leischow, Scott J.
AU - Robinson, Robert G.
T1 - Menthol Cigarettes: Setting the Research Agenda.
JF - Nicotine & Tobacco Research
JO - Nicotine & Tobacco Research
JA - Nicotine Tob Res
Y1 - 2004/02//
VL - 6
IS - Suppl1
SP - S5
EP - S9
CY - United Kingdom
PB - Taylor & Francis
SN - 1462-2203
SN - 1469-994X
AD - Clark, Pamela I., Battelle Centers for Public Health Research and Evaluation, 6115 Falls Road, Suite 200, Baltimore, MD, US, 21209
N1 - Accession Number: 2004-13628-002. Partial author list: First Author & Affiliation: Clark, Pamela I.; Battelle Centers for Public Health Research and Evaluation, Baltimore, MD, US. Other Publishers: Oxford University Press. Release Date: 20050222. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Conference on Menthol Cigarettes: Setting the Research Agenda, 1st, Mar, 2002, Atlanta, GA, US. Conference Note: Portions of this research were presented at the aformentioned conference. Major Descriptor: Consumer Behavior; Tobacco Smoking; Toxicity. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Feb, 2004.
AB - This supplement to Nicotine & Tobacco Research provides a summary of the state of our knowledge of the history, sociology, epidemiology, and toxicology of menthol cigarettes as well as the proposed future research agenda. Menthol is unique in that it is the only cigarette additive actively marketed to consumers. It is the only aspect of cigarette design that is marketed explicitly based on its physiological effects, as an anti-irritant and a cooling agent. It is the only cigarette additive about which consumers make conscious buying choices. Menthol, a chemical compound extracted from the peppermint plant and classified as a mild local anesthetic, was commonly used in veterinary medicine. Menthol stimulates cold receptors, with the resulting sensation of coolness perceived not only in the mouth and pharynx but also in the lungs. Stimulation of laryngeal cold receptors may reduce airway irritation. This sensation of coolness might result in deeper inhalation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - menthol cigarettes
KW - buying choices
KW - toxicology
KW - 2004
KW - Consumer Behavior
KW - Tobacco Smoking
KW - Toxicity
KW - 2004
DO - 10.1080/14622200310001649441
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13628-002&site=ehost-live&scope=site
UR - clarkp@battelle.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08432-022
AN - 2006-08432-022
AU - Finke, Bruce
AU - Bowannie, Theresa
AU - Kitzes, Judith
T1 - Palliative Care in the Pueblo of Zuni.
JF - Journal of Palliative Medicine
JO - Journal of Palliative Medicine
JA - J Palliat Med
Y1 - 2004/02//
VL - 7
IS - 1
SP - 135
EP - 143
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1096-6218
SN - 1557-7740
AD - Kitzes, Judith, University of New Mexico Health Sciences Center, PERT Epi-CC, MSC 11 6020, Albuquerque, MN, US, 87131-0001
N1 - Accession Number: 2006-08432-022. PMID: 15000797 Partial author list: First Author & Affiliation: Finke, Bruce; Indian Health Service, Rockville, MD, US. Release Date: 20070116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Palliative Care; Rural Environments; Terminally Ill Patients. Minor Descriptor: Cooperation; Death and Dying; Health Care Services; Hospice. Classification: Home Care & Hospice (3375). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2004.
AB - The American Indian and Alaska Native population is aging and the leading causes of death for those aged 55 and older are chronic diseases such as cancer, heart disease, and the complications of diabetes. There are limited formal palliative care services available to rural and reservation dwelling American Indians and Alaska Natives. This collaboration between a tribally operated home health care agency and a federally operated Indian Health Service hospital, with the support of a palliative care center within an academic medical center, has established a palliative care program in the Pueblo of Zuni. The program is based in the tribal home health agency. Barriers to development included the rural setting with limited professional workforce, competing demands in a small agency, the need for coordination across distinct organizations, and the need to address the dying process in a culturally proficient manner. Family- focused interviews and other techniques were used to tailor the palliative care program to the unique cultural setting. The program has sought to integrate inpatient care of terminally ill patients at the Indian Health Service (IHS) hospital with outpatient hospice care. The initial goal of obtaining certification as a Medicare Hospice provider has not been met and remains a goal. Meanwhile alternative mechanisms for funding the services have been found. The experience of this collaboration suggests that a tribally based, culturally proficient palliative care program can be developed within an American Indian/Alaska Native community and that it can drive the local health system toward improved end-of-life care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - palliative care services
KW - geriatrics
KW - Zuni
KW - rural setting
KW - cooperation
KW - Indian health services
KW - 2004
KW - Alaska Natives
KW - American Indians
KW - Palliative Care
KW - Rural Environments
KW - Terminally Ill Patients
KW - Cooperation
KW - Death and Dying
KW - Health Care Services
KW - Hospice
KW - 2004
DO - 10.1089/109662104322737403
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08432-022&site=ehost-live&scope=site
UR - JKitzes@Salud.unm.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11525-005
AN - 2004-11525-005
AU - Siegel, Sari
AU - Moy, Ernest
AU - Burstin, Helen
T1 - Assessing the Nation's Progress Toward Elimination of Disparities in Health Care: The National Healthcare Disparities Report.
JF - Journal of General Internal Medicine
JO - Journal of General Internal Medicine
JA - J Gen Intern Med
Y1 - 2004/02//
VL - 19
IS - 2
SP - 195
EP - 200
CY - United Kingdom
PB - Blackwell Publishing
SN - 0884-8734
SN - 1525-1497
AD - Siegel, Sari, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, 6th Floor, Rockville, MD, US, 20850
N1 - Accession Number: 2004-11525-005. PMID: 15009799 Partial author list: First Author & Affiliation: Siegel, Sari; Dept of Health & Human Services, Agency for Healthcare Research & Quality, Ctr for Primary Care, Prevention & Clinical Partnerships, Rockville, MD, US. Other Publishers: Springer. Release Date: 20050207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: General Practitioners; Primary Health Care; Quality of Care; Racial and Ethnic Groups; Socioeconomic Status. Minor Descriptor: Cultural Sensitivity; Health. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 6. Issue Publication Date: Feb, 2004.
AB - The Agency for Healthcare Research and Quality submitted the first annual National Healthcare Disparities Report to Congress in December, 2003. This first report will provide a snapshot of the state of racial, ethnic, and socioeconomic disparities in access and quality of care in America. It examines disparities in the general population and within the Agency's priority populations. While focused on extant data, the first report will form the foundation for future versions, which examines causes of disparities and shape solutions to the problem. As patient advocates and agents of change, primary care physicians play a critical role in efforts to eliminate disparities in health care. It is argued that continuing participation by primary care physicians in the development and refinement of the National Healthcare Disparities Report is essential. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - primary care physicians
KW - National Healthcare Disparities Report
KW - racial disparities
KW - ethnic disparities
KW - socioeconomic disparities
KW - access to care
KW - quality of care
KW - 2004
KW - General Practitioners
KW - Primary Health Care
KW - Quality of Care
KW - Racial and Ethnic Groups
KW - Socioeconomic Status
KW - Cultural Sensitivity
KW - Health
KW - 2004
DO - 10.1111/j.1525-1497.2004.30221.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11525-005&site=ehost-live&scope=site
UR - SSIEGEL@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10824-007
AN - 2004-10824-007
AU - Fiore, Michael C.
AU - Croyle, Robert T.
AU - Curry, Susan J.
AU - Cutler, Charles M.
AU - Davis, Ronald M.
AU - Gordon, Catherine
AU - Healton, Cheryl
AU - Koh, Howard K.
AU - Orleans, C. Tracy
AU - Richling, Dennis
AU - Satcher, David
AU - Seffrin, John
AU - Williams, Christine
AU - Williams, Larry N.
AU - Keller, Paula A.
AU - Baker, Timothy B.
T1 - Preventing 3 Million Premature Deaths and Helping 5 Million Smokers Quit: A National Action Plan for Tobacco Cessation.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2004/02//
VL - 94
IS - 2
SP - 205
EP - 210
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Fiore, Michael C., University of Wisconsin Medical School, Center for Tobacco Research and Intervention, 1930 Monroe St., Suite 200, Madison, WI, US, 53711
N1 - Accession Number: 2004-10824-007. PMID: 14759928 Partial author list: First Author & Affiliation: Fiore, Michael C.; Center for Tobacco Research and Intervention, University of Wisconsin Medical School, Madison, WI, US. Release Date: 20040719. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Government Programs; Health; Mortality Rate; Smoking Cessation; Tobacco Smoking. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. References Available: Y. Page Count: 6. Issue Publication Date: Feb, 2004.
AB - In August 2002, the Subcommittee on Cessation of the Interagency Committee on Smoking and Health (ICSH) was charged with developing recommendations to substantially increase rates of tobacco cessation in the United States. The subcommittee's report, A National Action Plan for Tobacco Cessation, outlines 10 recommendations for reducing premature morbidity and mortality by helping millions of Americans stop using tobacco. The plan includes both evidence-based, population-wide strategies designed to promote cessation (e.g., a national quitline network) and a Smokers' Health Fund to finance the programs (through a $2 per pack excise tax increase). The subcommittee report was presented to the ICSH (February 11, 2003), which unanimously endorsed sending it to Secretary Thompson for his consideration. In this article, we summarize the national action plan. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Subcommittee on Cessation of the Interagency Committee on Smoking and Health
KW - smoking cessation
KW - tobacco smoking
KW - National Action Plan for Tobacco Cessation
KW - premature morbidity
KW - mortality
KW - 2004
KW - Government Programs
KW - Health
KW - Mortality Rate
KW - Smoking Cessation
KW - Tobacco Smoking
KW - 2004
DO - 10.2105/AJPH.94.2.205
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10824-007&site=ehost-live&scope=site
UR - mcf@ctri.medicine.wisc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12175-003
AN - 2004-12175-003
AU - Larson, S. L.
AU - Clark, M. R.
AU - Eaton, W. W.
T1 - Depressive disorder as a long-term antecedent risk factor for incident back pain: A 13-year follow-up study from the Baltimore Epidemiological Catchment Area Sample.
JF - Psychological Medicine
JO - Psychological Medicine
JA - Psychol Med
Y1 - 2004/02//
VL - 34
IS - 2
SP - 211
EP - 219
CY - United Kingdom
PB - Cambridge University Press
SN - 0033-2917
SN - 1469-8978
AD - Larson, S. L., Agency for Healthcare Research and Quality (AHQR), Center for Financing, Access and Cost Trends, Division of Social and Economic Research (CFACT-DSER), 540 Gaither Road, Suite 5000, Rockville, MD, US, 20850
N1 - Accession Number: 2004-12175-003. PMID: 14982127 Partial author list: First Author & Affiliation: Larson, S. L.; Centre for Cost and Financing Studies, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20040426. Correction Date: 20120611. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Back Pain; Major Depression; Risk Factors. Minor Descriptor: Epidemiology. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Diagnostic Interview Schedule; General Health Questionnaire. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2004.
AB - This study examines the relationship between lifetime occurrence of depressive disorder and incident back pain reported over a 13-year period. The Baltimore Epidemiologic Catchment Area Study is a prospective study of a household-residing cohort, selected probabilistically from East Baltimore in 1981. Between 1982-3 (wave 2) and again between 1993-6 (wave 3), a follow-up study of the original cohort was conducted. In cross-sectional analyses, lifetime occurrence of depressive disorder was a significant correlate of lifetime prevalence of back pain at wave 1 (OR = 1.6, P = 0.01). During the 13-year follow-up, across three data collection points, there was an increase in the risk for incident back pain when depressive disorder was present at baseline. Depressive disorder appears to be a risk factor for incident back pain independent of other characteristics often associated with back pain. Back pain is not a short-term consequence of depressive disorder but emerges over periods longer than 1 year. Moreover, in this study the alternative pathway of back pain as a risk factor for depressive disorder could not be supported. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - back pain
KW - depressive disorder
KW - risk factor
KW - 2004
KW - Back Pain
KW - Major Depression
KW - Risk Factors
KW - Epidemiology
KW - 2004
DO - 10.1017/S0033291703001041
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12175-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12178-020
AN - 2004-12178-020
AU - Ferguson, Sherry A.
AU - Cada, Amy M.
T1 - Spatial learning/memory and social and nonsocial behaviors in the Spontaneously Hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains.
JF - Pharmacology, Biochemistry and Behavior
JO - Pharmacology, Biochemistry and Behavior
JA - Pharmacol Biochem Behav
Y1 - 2004/02//
VL - 77
IS - 3
SP - 583
EP - 594
CY - Netherlands
PB - Elsevier Science
SN - 0091-3057
AD - Ferguson, Sherry A., Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2004-12178-020. PMID: 15006470 Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20040426. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Social Behavior; Hypertension; Memory; Rats; Spatial Learning. Classification: Physiological Processes (2540). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Feb, 2004.
AB - The Spontaneously Hypertensive rat (SHR) is often described as less behaviorally reactive than its normotensive strain, the Wistar-Kyoto (WKY), although results are somewhat inconsistent across studies. In part, this may be due to the lack of a definitive characterization of 'reactivity.' Still, results from identical behavioral tests of SHR and WKY across studies are sometimes conflicting. Further, few comparisons with other rodent strains are available and these might provide guidance in outlining the meaning of reactivity. Here, social and nonsocial behaviors and spatial learning and memory were measured in male and female SHR, WKY, and Sprague-Dawley (SD) rats. Systolic blood pressure measurements at adulthood confirmed hypertension in the SHR. Juvenile play behavior indicated that SHRs were more sensitive to the strain of their play partner than were the WKY or SD, playing less with different strain partners than with same strain partners. These results do not support hypotheses of decreased behavioral reactivity in the SHR strain. Rather, they suggest complex interactions between social and nonsocial environments and the behavioral capabilities and requirements of the rat strain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - spatial learning
KW - memory
KW - social-nonsocial behaviors
KW - Spontaneously Hypertensive rats
KW - Wistar-Kyoto rats
KW - Sprague-Dawley rats
KW - rodent strains
KW - 2004
KW - Animal Social Behavior
KW - Hypertension
KW - Memory
KW - Rats
KW - Spatial Learning
KW - 2004
DO - 10.1016/j.pbb.2003.12.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12178-020&site=ehost-live&scope=site
UR - sferguson@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13628-008
AN - 2004-13628-008
AU - Giovino, Gary A.
AU - Sidney, Stephen
AU - Gfroerer, Joseph C.
AU - O'Malley, Patrick M.
AU - Allen, Jane A.
AU - Richter, Patricia A.
AU - Cummings, K. Michael
T1 - Epidemiology of menthol cigarette use.
JF - Nicotine & Tobacco Research
JO - Nicotine & Tobacco Research
JA - Nicotine Tob Res
Y1 - 2004/02//
VL - 6
IS - Suppl1
SP - S67
EP - S81
CY - United Kingdom
PB - Taylor & Francis
SN - 1462-2203
SN - 1469-994X
AD - Giovino, Gary A., Tobacco Control Research Program, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, US, 14263
N1 - Accession Number: 2004-13628-008. Partial author list: First Author & Affiliation: Giovino, Gary A.; Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, US. Other Publishers: Oxford University Press. Release Date: 20050222. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Health; Risk Factors; Tobacco Smoking. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Literature Review. References Available: Y. Page Count: 15. Issue Publication Date: Feb, 2004.
AB - Approximately one-fourth of ail cigarettes sold in the United States are mentholated. An understanding of the consequences, patterns, and correlates of menthol cigarette use can guide the development and implementation of strategies to reduce smoking prevalence and smoking-attributable morbidity and mortality. This paper summarizes the literature on the health effects of mentholated cigarettes and describes various patterns of use as indicated by consumption and survey data from the United States and other nations. The epidemiological literature on menthol cigarettes and cancer risk is inconclusive regarding whether these cigarettes confer a risk for cancer above that of nonmentholated varieties. Available data indicate that mentholated cigarettes are at least as dangerous as their nonmentholated counterparts. In addition, because mentholation improves the taste of cigarettes for a substantial segment of the smoking population and appears to mask disease symptoms, this additive may facilitate initiation or inhibit quitting. Menthol market share is high in the Philippines (60%), Cameroon (35%-40%), Hong Kong (26%), the United States (26%), and Singapore (22%). Newport has become the leading menthol brand in the United States. Surveys from four nations indicate that menthol use among adult smokers is more common among females than males. Among U.S. smokers, 68.9% of Blacks, 29.2% of Hispanics, and 22.4% of Whites reported smoking a mentholated variety. Research is needed to better explain factors that may influence menthol preference, such as marketing, risk perceptions, brand formulation, and taste preferences. Such research would guide the development of potentially more effective programs and policies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - menthol cigarette use
KW - epidemiology
KW - health effects
KW - 2004
KW - Epidemiology
KW - Health
KW - Risk Factors
KW - Tobacco Smoking
KW - 2004
DO - 10.1080/14622203710001649696
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13628-008&site=ehost-live&scope=site
UR - gary.giovino@roswellpark.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13628-009
AN - 2004-13628-009
AU - Sutton, Charyn D.
AU - Robinson, Robert G.
T1 - The marketing of menthol cigarettes in the United States: Populations, messages, and channels.
JF - Nicotine & Tobacco Research
JO - Nicotine & Tobacco Research
JA - Nicotine Tob Res
Y1 - 2004/02//
VL - 6
IS - Suppl1
SP - S83
EP - S91
CY - United Kingdom
PB - Taylor & Francis
SN - 1462-2203
SN - 1469-994X
AD - Sutton, Charyn D., c/o The Onyx Group, P.O. Box 60, Bala Cynwyd, PA, US, 19004
N1 - Accession Number: 2004-13628-009. Partial author list: First Author & Affiliation: Sutton, Charyn D.; Onyx Group, Bala Cynwyd, PA, US. Other Publishers: Oxford University Press. Release Date: 20050222. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Marketing; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Blacks; Immigration; Middle School Students. Classification: Drug & Alcohol Usage (Legal) (2990); Marketing & Advertising (3940). Population: Human (10); Male (30); Female (40). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2004.
AB - This commentary looks at the marketing menthol cigarettes to various targeted populations--women, middle school youth and Asian/Pacific Islander immigrants as well as African Americans. The authors take the position that 'ethnic awareness' as evidenced in the advertising of menthol cigarette brands to African Americans is just one of four distinct messages that tobacco marketers have used for what they have termed the 'coolness' category. The other messages are: healthy/medicinal; fresh/refreshing/cool/clean/crisp; and youthfulness/silliness and fun. The commentary poses three questions: (a) Are new population segments being steered toward menthol cigarettes using marketing approaches that are similar to what has occurred with African Americans and women? (b) What exactly is the relationship between the marketing of menthol cigarettes and subsequent use of menthol tobacco products by specific population subgroups? (c) Are there lessons to be learned from the marketing of menthol cigarettes that can be used to improve the public health and medical communities' smoking cessation and tobacco use prevention communications efforts?. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - menthol cigarettes
KW - marketing
KW - African Americans
KW - immigrants
KW - 2004
KW - Marketing
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Blacks
KW - Immigration
KW - Middle School Students
KW - 2004
DO - 10.1080/14622203310001649504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13628-009&site=ehost-live&scope=site
UR - charynsutton@onyx-group.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Jacobs, Abigail C.
AU - Brown, Paul C.
AU - Chen, Conrad
AU - Ellis, Amy
AU - Farrelly, James
AU - Osterberg, Robert
T1 - CDER Photosafety Guidance for Industry.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2004/02/02/Feb2004 Supplement
VL - 32
IS - 2S
M3 - Article
SP - 17
EP - 18
SN - 01926233
AB - In the Federal Register of January 10, 2000 (65 FR 1399), FDA published a draft guidance entitled “Photosafety Testing.” The notice gave interested persons an opportunity to submit comments. As a result of the comments, certain sections of the guidance were reworded to improve clarity. A final guidance was published in May 2003. The final guidance further emphasizes that a flexible approach can be used to address adverse photoeffects and that specific assays are not required. Moreover, it encourages the development of methods that can efficiently be used to evaluate human safety. The guidance describes a consistent, science-based approach for testing of topically and systemically administered drug products. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CDER guidance
KW - Photoirritation
KW - photosensitivity
N1 - Accession Number: 54381099; Jacobs, Abigail C. 1; Brown, Paul C. 2; Chen, Conrad 2; Ellis, Amy 2; Farrelly, James 2; Osterberg, Robert 2; Affiliations: 1: Center for Drug Evaluation and Research/U.S. Food and Drug Administration (CDER/FDA), Rockville, Maryland 20857, USA, jacobsa@cder.fda.gov; 2: Center for Drug Evaluation and Research/U.S. Food and Drug Administration (CDER/FDA), Rockville, Maryland 20857, USA; Issue Info: Feb2004 Supplement, Vol. 32 Issue 2S, p17; Author-Supplied Keyword: CDER guidance; Author-Supplied Keyword: Photoirritation; Author-Supplied Keyword: photosensitivity; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1176
L3 - 10.1080/01926230490463821
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=54381099&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ellenberger, Dennis
AU - Li, Bin
AU - Smith, James
AU - Yi, Hong
AU - Folks, Thomas
AU - Robinson, Harriet
AU - Butera, Salvatore
T1 - Optimization of a multi-gene HIV-1 recombinant subtype CRF02_AG DNA vaccine for expression of multiple immunogenic forms
JO - Virology
JF - Virology
Y1 - 2004/02/05/
VL - 319
IS - 1
M3 - Article
SP - 118
SN - 00426822
AB - We developed an AIDS vaccine for Western and West-Central Africa based on a DNA plasmid vector expressing HIV-1 recombinant subtype CRF02_AG gag, pol, and env genes. To optimize the production of noninfectious HIV-like particles (VLPs) and potentially improve the effectiveness of the vaccine, we generated four potential vaccine constructs: the parental (IC2) and three modifications (IC25, IC48, and IC90) containing mutations within the HIV protease. While the parental construct IC2 expressed aggregates of Gag proteins, the IC25 construct resulted in the production of immature VLPs (the core comprises unprocessed Pr55Gag). The remaining two constructs (IC48 and IC90) produced mature VLPs (the core comprises processed capsid p24) in addition to immature VLPs and aggregates of Gag proteins. VLPs incorporated significant levels of mature gp120 envelope glycoprotein. Importantly, the mature VLPs were fusion competent and entered coreceptor-specific target cells. The production of multiple antigenic forms, including fusion-competent VLPs, by candidate DNA vaccine constructs may provide immunologic advantages for induction of protective cellular and humoral responses against HIV-1 proteins. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - DNA vaccines
KW - MICROBIAL mutation
KW - AFRICA
KW - CRF02_AG
KW - HIV-1 DNA vaccine
KW - HIV-like particles
KW - Protease mutation
KW - VLP
N1 - Accession Number: 12173464; Ellenberger, Dennis 1; Email Address: dellenberger@cdc.gov Li, Bin 1 Smith, James 2 Yi, Hong 3 Folks, Thomas 1 Robinson, Harriet 2 Butera, Salvatore 1; Affiliation: 1: HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA 2: Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA 3: Emory Neurology Microscopy Core Laboratory, Atlanta, GA 30322, USA; Source Info: Feb2004, Vol. 319 Issue 1, p118; Subject Term: HIV (Viruses); Subject Term: DNA vaccines; Subject Term: MICROBIAL mutation; Subject Term: AFRICA; Author-Supplied Keyword: CRF02_AG; Author-Supplied Keyword: HIV-1 DNA vaccine; Author-Supplied Keyword: HIV-like particles; Author-Supplied Keyword: Protease mutation; Author-Supplied Keyword: VLP; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.virol.2003.10.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12173464&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morgan, Gareth
T1 - An aspirin a day...
JO - New Scientist
JF - New Scientist
Y1 - 2004/02/07/
VL - 181
IS - 2433
M3 - Article
SP - 36
EP - 39
PB - Reed Business Information Limited (New Scientist)
SN - 02624079
AB - The article focuses on the drug, Aspirin. The humble little pill has reinvented itself as a wonder drug for all manner of diseases. Aspirin's blood-thinning properties make it an excellent long-term treatment to help prevent heart attacks and strokes, and it now appears that the drug could reduce the risk of developing cancer and Alzheimer's disease. Here is a case for regarding salicylate as a micronutrient, akin to vitamins and antioxidants, that is essential for maintaining good health There is good evidence to suggest that humans' natural diet would once have contained small but significant quantities of salicylates from fruit and vegetables.
KW - ASPIRIN
KW - DRUGS
KW - ALZHEIMER'S disease
KW - MYOCARDIAL infarction
KW - DIET
KW - SALICYLATES
KW - CEREBROVASCULAR disease
N1 - Accession Number: 12330830; Morgan, Gareth 1; Affiliation: 1: A public health practitioner at the National Public Health Service for Wales in Swansea.; Source Info: 2/7/2004, Vol. 181 Issue 2433, p36; Subject Term: ASPIRIN; Subject Term: DRUGS; Subject Term: ALZHEIMER'S disease; Subject Term: MYOCARDIAL infarction; Subject Term: DIET; Subject Term: SALICYLATES; Subject Term: CEREBROVASCULAR disease; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Diagram; Document Type: Article; Full Text Word Count: 2429
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12330830&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Lawrence X.
AU - Carlin, Alan S.
AU - Amidon, Gordon L.
AU - Hussain, Ajaz S.
T1 - Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2004/02/11/
VL - 270
IS - 1/2
M3 - Article
SP - 221
SN - 03785173
AB - The purpose of this report was to investigate the feasibility of using disk intrinsic dissolution rate (DIDR) to determine solubility class membership. We employed a VanKel dissolution apparatus fitted with a Wood’s intrinsic dissolution die. To test the robustness of the method, variations of DIDR with compression force, dissolution volume, distance of the drug disk from the bottom of the dissolution vessel, and drug disk rotation speed were studied using furosemide and metoprolol in pH 4.5 acetate buffer as a model system. The DIDRs of six low solubility and nine high solubility model drugs were then determined at pH 1.2, 4.5, and 6.8 and compared to their BCS solubility class membership. It was found that the compression force, dissolution medium volume, and die position had no significant effect on DIDR for the system studied. The proposed compression force, dissolution volume, die position, and rotation speed are 2000 psi, 900 ml, 0.5 in., and 100 rpm, respectively. The test results obtained from 15 model BCS drugs show a good relationship between the DIDR and BCS solubility classification with 0.1 mg/min/cm2 as a class boundary unless the dose is either extremely low or high where discrepancies may exist between the solubility and DIDR methods. Therefore, more scientific research and debates are needed before considered for regulatory purpose. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOLUBILITY
KW - METOPROLOL
KW - CARDIOVASCULAR agents
KW - DRUGS -- Effectiveness
KW - Biopharmaceutics classification system
KW - Disk intrinsic dissolution rate
KW - Dissolution
KW - Solubility
N1 - Accession Number: 11883864; Yu, Lawrence X. 1; Email Address: yul@cder.fda.gov Carlin, Alan S. 1 Amidon, Gordon L. 2 Hussain, Ajaz S. 1; Affiliation: 1: Food and Drug Administration, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, 5600 Fishers Lane, Rockville, MD 20857, USA 2: Department of Pharmaceutics, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA; Source Info: Feb2004, Vol. 270 Issue 1/2, p221; Subject Term: SOLUBILITY; Subject Term: METOPROLOL; Subject Term: CARDIOVASCULAR agents; Subject Term: DRUGS -- Effectiveness; Author-Supplied Keyword: Biopharmaceutics classification system; Author-Supplied Keyword: Disk intrinsic dissolution rate; Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Solubility; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ijpharm.2003.10.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Carol
AU - Casey, David
T1 - An infection control link nurse network in the care home setting.
JO - British Journal of Nursing
JF - British Journal of Nursing
Y1 - 2004/02/12/
VL - 13
IS - 3
M3 - Article
SP - 166
EP - 170
SN - 09660461
AB - Link nurse groups or networks are used to enhance practice at clinical level (Cooper, 2001), improve the collaboration and education of nursing staff (MacArthur, 1998) and, therefore, have an effect on patient care. The use of link nurse networks is widespread and applied to a range of nursing specialties, particularly in acute settings. Reference in the literature to link nurse networks in nursing homes is very limited, despite their existence. This article examines the advantages and disadvantages of link nurse networks and the fink nurse role as described in the literature. In addition, comparisons are made with an established infection control link nurse network in North Wales nursing homes. The article describes the assessment of the North Wales network using an audit cycle. The efficacy of link nurse networks is rarely considered; however, the process of audit can enable the evaluation of the link nurse network in relation to staff education, monitoring of infection control practice and dissemination of information. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Nursing is the property of Mark Allen Holdings Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING
KW - NURSING care facilities
KW - HEALTH facilities
KW - MEDICAL care
KW - INFECTION
KW - PATIENTS
N1 - Accession Number: 12391393; Roberts, Carol 1 Casey, David 2; Affiliation: 1: Senior Infection Control Nurse, Health Protection Team (North Wales), National Public Health Service for Wales 2: Senior Infection Control Nurse, Ysbyty Glan Clwyd, North Wales; Source Info: 2/12/2004, Vol. 13 Issue 3, p166; Subject Term: NURSING; Subject Term: NURSING care facilities; Subject Term: HEALTH facilities; Subject Term: MEDICAL care; Subject Term: INFECTION; Subject Term: PATIENTS; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106743299
T1 - Link nursing. An infection control link nurse network in the care home setting.
AU - Roberts C
AU - Casey D
Y1 - 2004/02/12/
N1 - Accession Number: 106743299. Language: English. Entry Date: 20040611. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9212059.
KW - Community Health Nursing -- Administration
KW - Infection Preventionists -- Administration
KW - Nursing Homes
KW - Community Health Nursing -- Education
KW - Education, Nursing, Continuing -- Administration
KW - Evaluation Research
KW - Infection Preventionists -- Education
KW - Nurses -- Education
KW - Nursing Audit -- Administration
KW - Nursing Role
KW - Staff Development -- Administration
KW - Wales
KW - Human
SP - 166
EP - 170
JO - British Journal of Nursing
JF - British Journal of Nursing
JA - BR J NURS
VL - 13
IS - 3
PB - Mark Allen Holdings Limited
AB - Link nurse groups or networks are used to enhance practice at clinical level (Cooper, 2001), improve the collaboration and education of nursing staff (MacArthur, 1998) and, therefore, have an effect on patient care. The use of link nurse networks is widespread and applied to a range of nursing specialties, particularly in acute settings. Reference in the literature to link nurse networks in nursing homes is very limited, despite their existence. This article examines the advantages and disadvantages of link nurse networks and the link nurse role as described in the literature. In addition, comparisons are made with an established infection control link nurse network in North Wales nursing homes. The article describes the assessment of the North Wales network using an audit cycle. The efficacy of link nurse networks is rarely considered; however, the process of audit can enable the evaluation of the link nurse network in relation to staff education, monitoring of infection control practice and dissemination of information.
SN - 0966-0461
AD - Senior Infection Control Nurse, Health Protection Team (North Wales), National Public Health Service for Wales
U2 - PMID: 14997079.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Castranova, Vincent
T1 - Symposium Proceedings--Occupational Lung Disease in Response to Mixed Exposures: Approaches to Identify the Toxicity of Process-Dependent Contaminants.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/02/13/
VL - 67
IS - 3
M3 - Article
SP - 193
EP - 194
SN - 15287394
AB - Introduces a series of articles on occupational lung disease in response to mixed exposures. Approaches to identifying the toxicity of process-dependent contaminants; Exposure limits set by government authorities for individual particulate agents or chemical compounds; Complex mixed aerosols generated by modern industrial operations; Increasing awareness that the toxicity of a mixed exposure may not simply be the additive effects of its components.
KW - LUNG diseases
KW - OCCUPATIONAL diseases
KW - TOXICOLOGY
KW - POISONOUS gases
KW - INDUSTRIAL hygiene
KW - ENVIRONMENTAL health
N1 - Accession Number: 11715207; Castranova, Vincent 1; Affiliation: 1: National Institute for Occupational Safety and Health; Source Info: 2004, Vol. 67 Issue 3, p193; Subject Term: LUNG diseases; Subject Term: OCCUPATIONAL diseases; Subject Term: TOXICOLOGY; Subject Term: POISONOUS gases; Subject Term: INDUSTRIAL hygiene; Subject Term: ENVIRONMENTAL health; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Taylor, Michael D.
AU - Zimmer, Anthony T.
AU - Roberts, Jenny R.
T1 - Pulmonary Responses to Welding Fumes: Role of Metal Constituents.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/02/13/
VL - 67
IS - 3
M3 - Article
SP - 233
EP - 249
SN - 15287394
AB - It is estimated that more than 1 million workers worldwide perform some type of welding as part of their work duties. Epidemiology studies have shown that a large number of welders experience some type of respiratory illness. Respiratory effects seen in full-time welders have included bronchitis, siderosis, asthma, and a possible increase in the incidence of lung cancer. Pulmonary infections are increased in terms of severity, duration, and frequency among welders. Inhalation exposure to welding fumes may vary due to differences in the materials used and methods employed. The chemical properties of welding fumes can be quite complex. Most welding materials are alloy mixtures of metals characterized by different steels that may contain iron, manganese, chromium, and nickel. Animal studies have indicated that the presence and combination of different metal constituents is an important determinant in the potential pneumotoxic responses associated with welding fumes. Animal models have demonstrated that stainless steel (SS) welding fumes, which contain significant levels of nickel and chromium, induce more lung injury and inflammation, and are retained in the lungs longer than mild steel (MS) welding fumes, which contain mostly iron. In addition, SS fumes generated from welding processes using fluxes to protect the resulting weld contain elevated levels of soluble metals, which may affect respiratory health. Recent animal studies have indicated that the lung injury and inflammation induced by SS welding fumes that contain water-soluble metals are dependent on both the soluble and insoluble fractions of the fume. This article reviews the role that metals play in the pulmonary effects associated with welding fume exposure in workers and laboratory animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WELDING -- Health aspects
KW - WELDING fumes
KW - POISONOUS gases
KW - WELDERS (Persons)
KW - RESPIRATORY diseases
KW - TOXICOLOGY
N1 - Accession Number: 11715206; Antonini, James M. 1; Email Address: jga6@cdc.gov Taylor, Michael D. 1 Zimmer, Anthony T. 2 Roberts, Jenny R. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health; Source Info: 2004, Vol. 67 Issue 3, p233; Subject Term: WELDING -- Health aspects; Subject Term: WELDING fumes; Subject Term: POISONOUS gases; Subject Term: WELDERS (Persons); Subject Term: RESPIRATORY diseases; Subject Term: TOXICOLOGY; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Jenny R.
AU - Taylor, Michael D.
AU - Castranova, Vincent
AU - Clarke, Robert W.
AU - Antonini, James M.
T1 - Soluble Metals Associated with Residual Oil Fly Ash Increase Morbidity and Lung Injury after Bacterial Infection in Rats.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/02/13/
VL - 67
IS - 3
M3 - Article
SP - 251
EP - 263
SN - 15287394
AB - Inhalation of residual oil fly ash (ROFA) has been shown to impair lung defense mechanisms in laboratory animals and susceptible populations. Bioavailability of soluble transition metals has been shown to play a key role in lung injury caused by ROFA exposure. The goal of this study was to evaluate the effect of soluble metals on lung defense and injury in animals preexposed to ROFA followed by pulmonary challenge with a bacterial pathogen. ROFA was suspended in saline (ROFA-TOTAL), incubated overnight at 37 °C, and separated by centrifugation into soluble (ROFA-SOL) and insoluble (ROFA-INSOL) fractions. A portion of the soluble sample was treated with the metal-binding resin Chelex for 24 h at 37 °C. Sprague-Dawley rats were intratracheally dosed at d 0 with ROFA-TOTAL (1.0 mg/100 g body weight), ROFA-INSOL, ROFA-SOL, saline, saline + Chelex, or ROFA-SOL + Chelex. At d 3, 5 ×10 5 Listeria monocytogenes were intratracheally instilled into rats from each treatment group. At d 6, 8, and 10, left lungs were removed, homogenized, and cultured to assess bacterial clearance. Histopathological analysis was performed on the right lungs. Pulmonary exposure of ROFA-TOTAL or ROFA-SOL before infection led to a marked increase in lung injury and inflammation at all three time points after inoculation, and an increase in morbidity in comparison to saline control rats. Treatment with ROFA-INSOL, saline + Chelex, or ROFA-SOL + Chelex caused no significant increases in lung damage and morbidity when compared to control. By d 10, the ROFA-SOL and ROFA-TOTAL groups had approximately 200-fold more bacteria in the lung than saline control, indicating the inability of these groups to effectively respond to the infection. None of the other treatment groups had significant impairments in bacterial clearance when compared to saline. In conclusion, exposure to ROFA-TOTAL and ROFA-SOL significantly suppressed the lung response to infection. These results suggest that soluble metals present in ROFA may play a key role in increased susceptibility to pulmonary infection in exposed populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POISONOUS gases
KW - LUNG diseases
KW - BACTERIA
KW - PATHOGENIC microorganisms
KW - TOXICOLOGY
KW - ENVIRONMENTAL health
N1 - Accession Number: 11715209; Roberts, Jenny R. 1; Email Address: jur6@cdc.gov Taylor, Michael D. 2 Castranova, Vincent 1 Clarke, Robert W. 3 Antonini, James M.; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Department of Physiology and Pharmacology, West Virginia University 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health 3: Department of Environmental Health, Harvard School of Public Health; Source Info: 2004, Vol. 67 Issue 3, p251; Subject Term: POISONOUS gases; Subject Term: LUNG diseases; Subject Term: BACTERIA; Subject Term: PATHOGENIC microorganisms; Subject Term: TOXICOLOGY; Subject Term: ENVIRONMENTAL health; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, H.W.
AU - Yin, X.J.
AU - Frazer, D.
AU - Barger, M.W.
AU - Siegel, P.D.
AU - Millecchia, L.
AU - Zhong, B.Z.
AU - Tomblyn, S.
AU - Stone, S.
AU - Ma, J.K.H.
AU - Castranova, V.
AU - Ma, J.Y.C.
T1 - Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the rat lung
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2004/02/14/
VL - 557
IS - 2
M3 - Article
SP - 137
SN - 13835718
AB - Asphalt fumes are complex mixtures of aerosols and vapors containing various organic compounds, including polycyclic aromatic hydrocarbons (PAHs). Previously, we have demonstrated that inhalation exposure of rats to asphalt fumes resulted in dose-dependent induction of CYP1A1 with concomitant down-regulation of CYP2B1 and increased phase II enzyme quinone reductase activity in the rat lung. In the present study, the potential genotoxic effects of asphalt fume exposure due to altered lung microsomal enzymes were studied. Rats were exposed to air or asphalt fume generated under road paving conditions at various concentrations and sacrificed the next day. Alveolar macrophages (AM) were obtained by bronchoalveolar lavage and examined for DNA damage using the comet assay. To evaluate the systemic genotoxic effect of asphalt fume, micronuclei formation in bone marrow polychromatic erythrocytes (PCEs) was monitored. Lung S9 from various exposure groups was isolated from tissue homogenates and characterized for metabolic activity in activating 2-aminoanthracene (2-AA) and benzo[a]pyrene (BaP) mutagenicity using the Ames test with Salmonella typhimurium YG1024 and YG1029. This study showed that the paving asphalt fumes significantly induced DNA damage in AM, as revealed by DNA migration in the comet assay, in a dose-dependent manner, whereas the micronuclei formation in bone marrow PCEs was not detected even at a very high exposure level (1733 mg h/m3). The conversion of 2-AA to mutagens in the Ames test required lung S9-mediated metabolic activation in a dose-dependent manner. In comparison to the controls, lung S9 from rats exposed to asphalt fume at a total exposure level of 479±33 mg h/m3 did not significantly enhance 2-AA mutagenicity with either S. typhimurium YG1024 or YG1029. At a higher total asphalt fume exposure level (1150±63 mg h/m3), S9 significantly increased the mutagenicity of 2-AA as compared to the control. However, S9 from asphalt fume-exposed rats did not significantly activate the mutagenicity of BaP in the Ames test. These results show that asphalt fume exposure, which significantly altered both phases I and II metabolic enzymes in lung microsomes, is genotoxic to AM and enhances the metabolic activation of certain mutagens through altered S9 content. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt
KW - Polycyclic aromatic compounds
KW - Aerosols (Sprays)
KW - Hydrocarbons
KW - CYP1A1
KW - CYP2B1
KW - DNA damage
KW - Mutagenicity
KW - Paving asphalt fumes
KW - Polycyclic aromatic hydrocarbons
N1 - Accession Number: 11885901; Zhao, H.W. 1; Yin, X.J. 2; Frazer, D. 1; Barger, M.W. 1; Siegel, P.D. 1; Millecchia, L. 1; Zhong, B.Z. 1; Tomblyn, S. 1; Stone, S. 1; Ma, J.K.H. 2; Castranova, V. 1; Ma, J.Y.C. 1; Email Address: jym1@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; 2: School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Issue Info: Feb2004, Vol. 557 Issue 2, p137; Thesaurus Term: Asphalt; Thesaurus Term: Polycyclic aromatic compounds; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Hydrocarbons; Author-Supplied Keyword: CYP1A1; Author-Supplied Keyword: CYP2B1; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Paving asphalt fumes; Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.mrgentox.2003.10.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106744886
T1 - Counseling to prevent skin cancer: recommendations and rationale.
AU - Berg AO
Y1 - 2004/02/15/
N1 - Accession Number: 106744886. Corporate Author: US Preventive Services Task Force. Language: English. Entry Date: 20040611. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Counseling
KW - Preventive Health Care
KW - Skin Neoplasms -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Health Behavior
KW - Medical Practice, Evidence-Based
KW - Sunlight -- Adverse Effects
KW - Sunscreening Agents -- Utilization
SP - 903
EP - 1004
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 69
IS - 4
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - U.S. Preventive Services Task Force: recommendations and rationale series
SN - 0002-838X
AD - Chair, US Preventive Services Task Force, c/o Project Director, USPSTF, 540 Gaither Rd, Rockville, MD 20850; uspstf@ahrq.gov
U2 - PMID: 14989578.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Williams, Tracie L.
AU - Callahan, John H.
AU - Monday, Steven R.
AU - Feng, Peter C. H.
AU - Musser, Steven M.
T1 - Relative Quantitation of Intact Proteins of Bacterial Cell Extracts Using Coextracted Proteins as Internal Standards.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2004/02/15/
VL - 76
IS - 4
M3 - Article
SP - 1002
EP - 1007
SN - 00032700
AB - aA method for quantitating protein expression using LC/MS of whole proteins is described. This method is based on the fact that some proteins present in cells are abundant universal proteins whose expression levels exhibit lithe variation. This method demonstrates that these coextracted proteins can be used as internal standards to which the other proteins in the sample can be compared. By comparing the intensities of a selected protein to marker proteins, or internal standards, a relative ratio is obtained. This ratio can then be used to determine the relative amount of protein expression between cellular extracts. The validity of this approach is described for a standard protein mixture, as well as, E. coil cells that were known to differentially express green fluorescent protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - MASS spectrometry
KW - CHROMATOGRAPHIC analysis
KW - CELLS
KW - EXTRACTION (Chemistry)
KW - BACTERIA
N1 - Accession Number: 12464276; Williams, Tracie L. 1; Email Address: tracie.williams@cfsan.fda.gov Callahan, John H. 1 Monday, Steven R. 1 Feng, Peter C. H. 1 Musser, Steven M. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740-3835.; Source Info: 2/15/2004, Vol. 76 Issue 4, p1002; Subject Term: PROTEINS; Subject Term: MASS spectrometry; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CELLS; Subject Term: EXTRACTION (Chemistry); Subject Term: BACTERIA; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kennedy, Dianne L.
AU - Uhl, Kathleen
AU - Kweder, Sandra L.
T1 - Pregnancy Exposure Registries.
JO - Drug Safety
JF - Drug Safety
Y1 - 2004/02/15/
VL - 27
IS - 4
M3 - Article
SP - 215
EP - 228
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Scientifically valid data on the safety of drug use during pregnancy are a significant public health need. Data are rarely available on the fetal effects of in utero exposure in human pregnancies, particularly where when a drug is first marketed. Data from animal reproductive toxicology studies, which function as a screen for potential human teratogenicity, are usually all that is available in a product's labelling. For practicing clinicians, translating known animal risks into an accurate assessment of teratogenic risks in their patients is very difficult, if not impossible. Without human data on the effects of in utero drug exposure, it is difficult for physicians and other healthcare providers (e.g. genetic counselors) to adequately counsel patients about fetal risks. Therefore, a pregnant woman may decide to unnecessarily terminate a wanted pregnancy or forego needed drug therapy. In spite of the lack of data on the safety of drug use during human pregnancies, pregnant women are exposed to drugs either as prescribed therapy or inadvertently before pregnancy is known (over one-half of pregnancies are unplanned). Because little is known about the teratogentic potential of a drug in humans before marketing, post-marketing surveillance of drug use in pregnancy is critical to the detection of drug-induced fetal effects. The existing passive mechanism of spontaneous reporting of adverse drug effects is inadequate to routinely detect drug-induced fetal risks or lack of such risks. Therefore, post-marketing for major fetal effects and to describe margins of safety associated with drug exposure during pregnancy. However, differing methodological rigour has been applied to the development of pregnancy exposure registries. It is important that all pregnancy registries develop epidemiologically sound written study protocols a priori. It is only through the use of rigourous methodology and procedures that data from pregnancy exposure registers will withstand scientific scrutiny. Successful recruitment of an adequate number of exposed pregnancies, aggressive, follow-up, and complete and accurate ascertainment of pregnancy outcome are critical attributes of a well-designed registry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANCY
KW - REPRODUCTIVE toxicology
KW - DEVELOPMENTAL toxicology
KW - PUBLIC health
KW - DRUGS
KW - PHYSICIANS
N1 - Accession Number: 12753680; Kennedy, Dianne L. 1 Uhl, Kathleen 1 Kweder, Sandra L. 1; Affiliation: 1: Pregnancy Labeling Task Force, US Food and Drug Administration, Rockville, Maryland, USA.; Source Info: 2004, Vol. 27 Issue 4, p215; Subject Term: PREGNANCY; Subject Term: REPRODUCTIVE toxicology; Subject Term: DEVELOPMENTAL toxicology; Subject Term: PUBLIC health; Subject Term: DRUGS; Subject Term: PHYSICIANS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liang, Xing-Jie
AU - Yin, Jun-Jie
AU - Zhou, Jien-Wei
AU - Wang, Paul C.
AU - Taylor, Barbara
AU - Cardarelli, Carol
AU - Kozar, Michael
AU - Forte, Raynard
AU - Aszalos, Adorjan
AU - Gottesman, Michael M.
T1 - Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells
JO - Experimental Cell Research
JF - Experimental Cell Research
Y1 - 2004/02/15/
VL - 293
IS - 2
M3 - Article
SP - 283
SN - 00144827
AB - The mechanism of resistance of cancer cells to the anticancer drug cisplatin is not fully understood. Using cisplatin-sensitive KB-3-1 and -resistant KCP-20 cells, we found that the resistant cells have higher membrane potential, as determined by membrane potential sensing oxonol dye. Electron spin resonance and fluorescence polarization studies revealed that the resistant cells have more “fluid” plasma membranes than the sensitive cells. Because of this observed difference in membrane “fluidity,” we attempted modification of the plasma membrane fluidity by the incorporation of heptadecanoic acid into KB-3-1 and KCP-20 cell membranes. We found that such treatment resulted in increased heptadecanoic acid content and increased fluidity in the plasma membranes of both cell types, and also resulted in increased cisplatin resistance in the KCP-20 cells. This finding is in accord with our results, which showed that the cisplatin-resistant KCP-20 cells have more fluid membranes than the cisplatin-sensitive KB-3-1 cells. It remains to be determined whether the observed differences in biophysical status and/or fatty acid composition alone, or the secondary effect of these differences on the structure or function of some transmembrane protein(s), is the reason for increased cisplatin resistance. [Copyright &y& Elsevier]
AB - Copyright of Experimental Cell Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER cells
KW - CISPLATIN
KW - CELL membranes
KW - FLUORESCENCE
KW - Cisplatin resistance
KW - Fluorescence polarization
KW - Heptadecanoic acid
KW - Human epidermal carcinoma KB cells
KW - Membrane potential
KW - Plasma membrane fluidity
N1 - Accession Number: 11960494; Liang, Xing-Jie 1 Yin, Jun-Jie 2 Zhou, Jien-Wei 3 Wang, Paul C. 3 Taylor, Barbara 1 Cardarelli, Carol 1 Kozar, Michael 4 Forte, Raynard 4 Aszalos, Adorjan 1 Gottesman, Michael M. 1; Email Address: mgottesman@nih.gov; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4254, USA 2: Instrumentation and Biophysics Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA 3: Department of Radiology, Howard University, Washington, DC 20060, USA 4: Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Source Info: Feb2004, Vol. 293 Issue 2, p283; Subject Term: CANCER cells; Subject Term: CISPLATIN; Subject Term: CELL membranes; Subject Term: FLUORESCENCE; Author-Supplied Keyword: Cisplatin resistance; Author-Supplied Keyword: Fluorescence polarization; Author-Supplied Keyword: Heptadecanoic acid; Author-Supplied Keyword: Human epidermal carcinoma KB cells; Author-Supplied Keyword: Membrane potential; Author-Supplied Keyword: Plasma membrane fluidity; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.yexcr.2003.10.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nayak, R.
AU - Stewart, T.
AU - Wang, R.-F.
AU - Lin, J.
AU - Cerniglia, C.E.
AU - Kenney, P.B.
T1 - Genetic diversity and virulence gene determinants of antibiotic-resistant Salmonella isolated from preharvest turkey production sources
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2004/02/15/
VL - 91
IS - 1
M3 - Article
SP - 51
SN - 01681605
AB - This study evaluated the molecular diversity of 29 Salmonella serotypes isolated from turkey ceca and the production environment. Isolates were resistant to bacitracin (100%), erythromycin (100%), novobiocin (100%), rifampin (100%), streptomycin (62%), gentamicin (52%), spectinomycin (48%), tetracycline (31%), sulfamethoxazole/trimethoprim (SXT) (3%) and tobramycin (3%). The minimum inhibitory concentration (MIC) values ranged from 32 to ≥1024 μg/ml. The pulsed-field gel electrophoresis (PFGE) and ribotyping patterns were identical within each of the serotypes Heidelberg, Worthington and Muenster. The plasmid profiles were identical within each of the Salmonella serotypes. Two different clones of Salmonella anatum were differentiated by PFGE typing but not by ribotyping. Heidelberg isolates from nine turkey ceca and three drinker samples had identical antibiotic resistance, PFGE, ribotype and plasmid patterns, suggesting that transmission of this particular clone may have occurred between the birds and the drinkers. Identical PFGE, ribotype and plasmid patterns were observed in one Salmonella worthington isolate from turkey ceca in one flock and two S. worthington isolates from feeder contents and drinkers from a subsequent flock, suggesting transmission of this pathogen between flocks. Individual and multiple polymerase chain reaction (PCR) analyses revealed the presence of the virulence genes invA, aceK and sopB and the absence of the h-1i gene in all isolates. A combination of genotypic and phenotypic markers can be useful in studying genetic variation among natural salmonellae populations in turkey production and delineating possible transmission pathways. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Molecular dynamics
KW - Bacitracin
KW - Turkey
KW - Antibiotic resistance
KW - Molecular typing
N1 - Accession Number: 12170055; Nayak, R. 1; Email Address: RNayak@nctr.fda.gov; Stewart, T. 1; Wang, R.-F. 1; Lin, J. 2; Cerniglia, C.E. 1; Kenney, P.B. 3; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; 2: Pacific Regional Laboratory SW, US Food and Drug Administration, Los Angeles, CA 90015, USA; 3: Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, WV 26505, USA; Issue Info: Feb2004, Vol. 91 Issue 1, p51; Thesaurus Term: Salmonella; Subject Term: Molecular dynamics; Subject Term: Bacitracin; Subject: Turkey; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: Molecular typing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S0168-1605(03)00330-1
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gurer-Orhan, Hande
AU - Sabır, Handan U.
AU - Özgüneş, Hilal
T1 - Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers
JO - Toxicology
JF - Toxicology
Y1 - 2004/02/15/
VL - 195
IS - 2/3
M3 - Article
SP - 147
SN - 0300483X
AB - The present study was undertaken to investigate the involvement of oxidative damage in lead-induced toxicity in humans and to enlighten whether oxidative stress indicators are correlated with the known indices of lead toxicity. For these purposes, selected oxidative stress parameters along with some clinical indices of lead poisoning were determined in blood of battery plant workers and control subjects. Workers had significantly increased erythrocyte malondialdehyde (MDA) levels, catalase and glucose-6-phosphate dehydrogenase (G6PD) activities, and decreased blood glutathione:glutathione disulfide ratio compared to the controls. Increased blood lead concentrations and zinc protoporphyrin (ZPP) levels, and decreased δ-aminolevulinic acid dehydratase (ALAD) activity were used as clinical indices of lead toxicity. Statistically significant correlation between oxidative stress parameters and clinical indices implies that disrupted prooxidant/antioxidant balance might contribute to lead-induced toxicity in erythrocytes. A significant correlation was found between ALAD activity and blood lead levels in human subjects. Similarly significant correlation between ALAD activity and erythrocyte MDA concentrations was shown. Present data indicates that ALAD can serve as a valuable biomarker of oxidative stress in lead-exposed hematological system as well as being a biochemical indicator of lead exposure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATIVE stress
KW - LEAD
KW - TOXICOLOGY
KW - ZINC
KW - δ-Aminolevulinic acid dehydratase
KW - Lead poisoning
KW - Oxidative stress
KW - Workers
N1 - Accession Number: 12042047; Gurer-Orhan, Hande 1; Email Address: handegurer@yahoo.com Sabır, Handan U. 2 Özgüneş, Hilal 1; Affiliation: 1: Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey 2: National Institute of Occupational Safety and Health, Etimesgut, Ankara, Turkey; Source Info: Feb2004, Vol. 195 Issue 2/3, p147; Subject Term: OXIDATIVE stress; Subject Term: LEAD; Subject Term: TOXICOLOGY; Subject Term: ZINC; Author-Supplied Keyword: δ-Aminolevulinic acid dehydratase; Author-Supplied Keyword: Lead poisoning; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Workers; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.tox.2003.09.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zeidler, Patti C.
AU - Millecchia, Lyndell M.
AU - Castranova, Vincent
T1 - Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-γ-induced pulmonary inflammation
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/02/15/
VL - 195
IS - 1
M3 - Article
SP - 45
SN - 0041008X
AB - Exposure of mice to lipopolysaccharide (LPS) plus interferon-γ (IFN-γ) increases nitric oxide (NO) production, which is proposed to play a role in the resulting pulmonary damage and inflammation. To determine the role of inducible nitric oxide synthase (iNOS)-induced NO in this lung reaction, the responses of inducible nitric oxide synthase knockout (iNOS KO) versus C57BL/6J wild-type (WT) mice to aspirated LPS + IFN-γ were compared. Male mice (8–10 weeks) were exposed to LPS (1.2 mg/kg) + IFN-γ (5000 U/mouse) or saline. At 24 or 72 h postexposure, lungs were lavaged with saline and the acellular fluid from the first bronchoalveolar lavage (BAL) was analyzed for total antioxidant capacity (TAC), lactate dehydrogenase (LDH) activity, albumin, tumor necrosis factor-α (TNF-α), and macrophage inflammatory protein-2 (MIP-2). The cellular fraction of the total BAL was used to determine alveolar macrophage (AM) and polymorphonuclear leukocyte (PMN) counts, and AM zymosan-stimulated chemiluminescence (AM-CL). Pulmonary responses 24 h postexposure to LPS + IFN-γ were characterized by significantly decreased TAC, increased BAL AMs and PMNs, LDH, albumin, TNF-α, and MIP-2, and enhanced AM-CL to the same extent in both WT and iNOS KO mice. Responses 72 h postexposure were similar; however, significant differences were found between WT and iNOS KO mice. iNOS KO mice demonstrated a greater decline in total antioxidant capacity, greater BAL PMNs, LDH, albumin, TNF-α, and MIP-2, and an enhanced AM-CL compared to the WT. These data suggest that the role of iNOS-derived NO in the pulmonary response to LPS + IFN-γ is anti-inflammatory, and this becomes evident over time. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitric oxide
KW - Endotoxins
KW - Albumins
KW - Pneumonia
KW - Inducible nitric oxide synthase
KW - Interferon-gamma
KW - Lipopolysaccharide
KW - Lung inflammation
N1 - Accession Number: 12176743; Zeidler, Patti C. 1,2; Millecchia, Lyndell M. 1; Castranova, Vincent 1,2; Email Address: vic1@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; 2: Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA; Issue Info: Feb2004, Vol. 195 Issue 1, p45; Thesaurus Term: Nitric oxide; Thesaurus Term: Endotoxins; Thesaurus Term: Albumins; Subject Term: Pneumonia; Author-Supplied Keyword: Inducible nitric oxide synthase; Author-Supplied Keyword: Interferon-gamma; Author-Supplied Keyword: Lipopolysaccharide; Author-Supplied Keyword: Lung inflammation; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2003.10.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kirma, Nameer
AU - Ferreira, Joseph L.
AU - Baumstark, Barbara R.
T1 - Characterization of six type A strains of Clostridium botulinum that contain type B toxin gene sequences
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/02/16/
VL - 231
IS - 2
M3 - Article
SP - 159
SN - 03781097
AB - Six Clostridium botulinum isolates exhibiting type A toxicity as measured by the mouse bioassay were found to contain both type A and type B neurotoxin DNA sequences. The six strains were divided into three groups based on the DNA sequence of the type B neurotoxin gene. Members of each group exhibited 100% sequence identity over the 3876 bp type B toxin open reading frame. The type B toxin sequence of all groups differed at more than 60 positions when compared to the BGB control strain. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Neurotoxic agents
KW - Clostridium botulinum
KW - Genes
KW - Polymerase chain reaction
KW - Neurotoxin gene sequence
N1 - Accession Number: 12310333; Kirma, Nameer 1; Email Address: nkirma@emory.edu; Ferreira, Joseph L. 2; Baumstark, Barbara R. 1; Affiliations: 1: Department of Biology, P.O. Box 4010, Georgia State University, Atlanta, GA 30302-4010, USA; 2: Food and Drug Administration, 60 8th Street, Atlanta, GA 30309, USA; Issue Info: Feb2004, Vol. 231 Issue 2, p159; Thesaurus Term: Neurotoxic agents; Subject Term: Clostridium botulinum; Subject Term: Genes; Subject Term: Polymerase chain reaction; Author-Supplied Keyword: Neurotoxin gene sequence; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0378-1097(03)00911-X
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Walker, Richard I.
AU - Blanchard, Thomas
AU - Braun, Jan Matthias
AU - Cebra, John J.
AU - Cross, Alan S.
AU - Fattom, Ali
AU - Giannasca, Paul J.
AU - Holder, Ian Alan
AU - Huebner, J.
AU - Matthews, Ruth
AU - Pier, Gerald B.
AU - Romani, Luigina
AU - von Specht, B.U.
AU - Trautmann, Matthias
T1 - Meeting summary: Possibilities for active and passive vaccination against opportunistic infections
JO - Vaccine
JF - Vaccine
Y1 - 2004/02/17/
VL - 22
IS - 7
M3 - Editorial
SP - 801
SN - 0264410X
N1 - Accession Number: 12097123; Walker, Richard I.; Email Address: walkerri@cber.fda.gov; Blanchard, Thomas 1; Braun, Jan Matthias 1; Cebra, John J. 1; Cross, Alan S. 1; Fattom, Ali 1; Giannasca, Paul J. 1; Holder, Ian Alan 1; Huebner, J. 1; Matthews, Ruth 1; Pier, Gerald B. 1; Romani, Luigina 1; von Specht, B.U. 1; Trautmann, Matthias 1; Affiliations: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA; Issue Info: Feb2004, Vol. 22 Issue 7, p801; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1016/j.vaccine.2003.11.042
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bao-Zhu Yuan, Edward E.
AU - Jefferson, Amy M.
AU - Baldwin, Kimberly T.
AU - Thorgeirsson, Snorri S.
AU - Popescu, Nicholas C.
AU - Reynolds, Steven H.
T1 - DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.
JO - Oncogene
JF - Oncogene
Y1 - 2004/02/19/
VL - 23
IS - 7
M3 - Article
SP - 1405
EP - 1411
PB - Nature Publishing Group
SN - 09509232
AB - The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth. Given the high frequency of deletion involving region 8p21-22 in human non-small cell lung carcinoma (NSCLC), we examined alterations of DLC-1 in a series of primary tumors and tumor cell lines and tested effects of DLC-1 on tumor cell growth. A significant decrease or absence of the DLC-1 mRNA expression was found in 95% of primary NSCLC (20/21) and 58% of NSCLC cell lines (11/19). Transcriptional silencing of DLC-1 was primarily associated with aberrant DNA methylation, rather than genomic deletion as 5-aza-2'-deoxycytidine induced reactivation of DLC-1 expression in 82% (9/11) NSCLC cell lines showing downregulated DLC-1. It was further evidenced by an aberrant DLC-1 promoter methylation pattern, which was detected by Southern blotting in 73% (8/11) of NSCLC cell lines with downregulation of the gene. The transfer of DLC-1 into three DLC-1 negative cell lines caused a significant inhibition in cell proliferation and/or a decrease in colony formation. Furthermore, stable transfer of DLC-1 abolished tumorigenicity in nude mice of two cell lines, suggesting that DLC-1 plays a role in NSCLC by acting as a bona fide new tumor suppressor gene.Oncogene (2004) 23, 1405-1411. doi:10.1038/sj.onc.1207291 Published online 8 December 2003 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIONCOGENES
KW - LIVER -- Cancer
KW - SMALL cell lung cancer
KW - METHYLATION
KW - CHROMOSOMES
KW - NUCLEOTIDE sequence
KW - CARCINOGENESIS
KW - aberrant DNA methylation
KW - DLC-1
KW - non-small cell lung carcinoma
KW - tumor suppressor gene
KW - tumorigenicity
N1 - Accession Number: 12324715; Bao-Zhu Yuan, Edward E. 1; Email Address: bby1@cdc.gov Jefferson, Amy M. 1 Baldwin, Kimberly T. 1 Thorgeirsson, Snorri S. 2 Popescu, Nicholas C. 2 Reynolds, Steven H. 1; Affiliation: 1: Laboratory of Genetic Susceptibility, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA; Source Info: 2/19/2004, Vol. 23 Issue 7, p1405; Subject Term: ANTIONCOGENES; Subject Term: LIVER -- Cancer; Subject Term: SMALL cell lung cancer; Subject Term: METHYLATION; Subject Term: CHROMOSOMES; Subject Term: NUCLEOTIDE sequence; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: aberrant DNA methylation; Author-Supplied Keyword: DLC-1; Author-Supplied Keyword: non-small cell lung carcinoma; Author-Supplied Keyword: tumor suppressor gene; Author-Supplied Keyword: tumorigenicity; Number of Pages: 7p; Illustrations: 6 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1038/sj.onc.1207291
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lopez, Hector
AU - Beer, Janusz Z.
AU - Miller, Sharon A.
AU - Zmudzka, Barbara Z.
T1 - Ultrasound measurements of skin thickness after UV exposure: a feasibility study
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2004/02/20/
VL - 73
IS - 3
M3 - Article
SP - 123
SN - 10111344
AB - High-frequency ultrasound images were used to measure the thickness of the dermis and epidermis of four human subjects. These measurements were performed before and after a single exposure to ultraviolet radiation (UV). Doses ranging from 0.5 to 3 minimal erythema doses (MED) were delivered to the skin of the back of four human subjects, and thickness measurements were made over a period of 16 days. We found: (1) exposures ⩾2 MED caused a 10–30% increase in the thickness of the dermis–epidermis layer; (2) the thickening response was not always in direct proportion to the UV dose; (3) maximum thickening response time was 48 h for the 2.8–3.0 MED exposure levels; (4) “diffusion” or spreading of the thickening response to neighboring areas occurred in some cases, as far as 4 cm from the exposed region (center-to-center), with changes ranging from 12% to 17%; (5) decreased thickness of the dermis–epidermis layer of up to 12% was observed for 3 out of 4 of the subjects. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology B: Biology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Physiology
KW - THICKNESS measurement
KW - INTRAVASCULAR ultrasonography
KW - EPIDERMIS
KW - Dermis
KW - Epidermis
KW - Human skin
KW - Skin exposure
KW - Skin thickness
KW - Ultrasound
KW - Ultraviolet radiation
N1 - Accession Number: 12236257; Lopez, Hector; Email Address: hxl8@cdrh.fda.gov Beer, Janusz Z. 1 Miller, Sharon A. 1 Zmudzka, Barbara Z. 1; Affiliation: 1: Food and Drug Administration, Department of Health and Human Services, Center for Devices and Radiological Health, Office of Science and Technology, 9200 Corporate Blvd., HFZ-132, Rockville, MD 20850, USA; Source Info: Feb2004, Vol. 73 Issue 3, p123; Subject Term: SKIN -- Physiology; Subject Term: THICKNESS measurement; Subject Term: INTRAVASCULAR ultrasonography; Subject Term: EPIDERMIS; Author-Supplied Keyword: Dermis; Author-Supplied Keyword: Epidermis; Author-Supplied Keyword: Human skin; Author-Supplied Keyword: Skin exposure; Author-Supplied Keyword: Skin thickness; Author-Supplied Keyword: Ultrasound; Author-Supplied Keyword: Ultraviolet radiation; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jphotobiol.2003.11.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Lawrence X.
AU - Lionberger, Robert A.
AU - Raw, Andre S.
AU - D'Costa, Rosario
AU - Wu, Huiquan
AU - Hussain, Ajaz S.
T1 - Applications of process analytical technology to crystallization processes
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2004/02/23/
VL - 56
IS - 3
M3 - Article
SP - 349
SN - 0169409X
AB - Crystallizations of pharmaceutical active ingredients, particularly those that posses multiple polymorphic forms, are among the most critical and least understood pharmaceutical manufacturing processes. Many process and product failures can be traced to a poor understanding and control of crystallization processes. The Food and Drug Administration''s process analytical technology (PAT) initiative is a collaborative effort with industry to introduce new and efficient manufacturing technologies into the pharmaceutical industry. PAT''s are systems for design, analysis, and control of manufacturing processes. They aim to assure high quality through timely measurements of critical quality and performance attributes of raw materials, in-process materials, and final products. Implementation of PAT involves scientifically based process design and optimization, appropriate sensor technologies, statistical and information tools (chemometrics), and feedback process control strategies working together to produce quality products. This review introduces the concept of PAT and discusses its application to crystallization processes through review of several case studies. A variety of in situ analytical methods combined with chemometric tools for analysis of multivariate process information provide a basis for future improvements in modeling, simulation, and control of crystallization processes. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYSTALLIZATION
KW - POLYMORPHISM (Crystallography)
KW - DRUGS
KW - HIGH throughput screening (Drug development)
KW - Control
KW - Crystallization
KW - In situ
KW - Modelling
KW - Polymorphism
KW - Process analytical technology
KW - Simulation
N1 - Accession Number: 12169956; Yu, Lawrence X. 1 Lionberger, Robert A. 1 Raw, Andre S. 1; Email Address: rawa@cder.fda.gov D'Costa, Rosario 1 Wu, Huiquan 2 Hussain, Ajaz S. 2; Email Address: hussaina@cder.fda.gov; Affiliation: 1: Office of Generic Drugs, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA 2: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: Feb2004, Vol. 56 Issue 3, p349; Subject Term: CRYSTALLIZATION; Subject Term: POLYMORPHISM (Crystallography); Subject Term: DRUGS; Subject Term: HIGH throughput screening (Drug development); Author-Supplied Keyword: Control; Author-Supplied Keyword: Crystallization; Author-Supplied Keyword: In situ; Author-Supplied Keyword: Modelling; Author-Supplied Keyword: Polymorphism; Author-Supplied Keyword: Process analytical technology; Author-Supplied Keyword: Simulation; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.addr.2003.10.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Passerini, Anthony G.
AU - Polacek, Denise C.
AU - Shi, Congzhu
AU - Francesco, Nadeene M.
AU - Manduchi, Elisabetta
AU - Grant, Gregory R.
AU - Pritchard, William F.
AU - Powell, Steven
AU - Chang, Gary Y.
AU - Stoeckert, Christian J.
AU - Jr.
AU - Davies, Peter F.
T1 - Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2004/02/24/
VL - 101
IS - 8
M3 - Article
SP - 2482
EP - 2487
SN - 00278424
AB - In the arterial circulation, regions of disturbed flow (DF), which are characterized by flow separation and transient vortices, are susceptible to atherogenesis, whereas regions of undisturbed laminar flow (UF) appear protected. Coordinated regulation of gene expression by endothelial cells (EC) may result in differing regional phenotypes that either favor or inhibit atherogenesis. Linearly amplified RNA from freshly isolated EC of DF (inner aortic arch) and UF (descending thoracic aorta) regions of normal adult pigs was used to profile differential gene expression reflecting the steady state in vivo. By using human cDNA arrays, ≈2,000 putatively differentially expressed genes were identified through false-discovery-rate statistical methods. A sampling of these genes was validated by quantitative real-time PCR and/or immunostaining en face. Biological pathway analysis revealed that in DF there was up-regulation of several broad-acting inflammatory cytokines and receptors, in addition to elements of the NF-κB system, which is consistent with a proinflammatory phenotype. However, the NF-κB complex was predominantly cytoplasmic (inactive) in both regions, and no significant differences were observed in the expression of key adhesion molecules for inflammatory cells associated with early atherogenesis. Furthermore, there was no histological evidence of inflammation. Protective profiles were observed in DF regions, notably an enhanced antioxidative gene expression. This study provides a public database of regional EC gene expression in a normal animal, implicates hemodynamics as a contributory mechanism to athero-susceptibility, and reveals the coexistence of pro- and antiatherosclerotic transcript profiles in susceptible regions. The introduction of additional risk factors may shift this balance to favor lesion development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LAMINAR flow
KW - AORTA
KW - RNA
KW - DNA
KW - GENE expression
KW - ENDOTHELIUM
N1 - Accession Number: 12927156; Passerini, Anthony G. 1,2 Polacek, Denise C. 1 Shi, Congzhu 1 Francesco, Nadeene M. 1 Manduchi, Elisabetta 3 Grant, Gregory R. 3 Pritchard, William F. 4 Powell, Steven 5 Chang, Gary Y. 1,2 Stoeckert, Christian J. Jr. 3,6 Davies, Peter F. 1,2,7; Email Address: pfd@pobox.upenn.edu; Affiliation: 1: institute for Medicine and Engineering, University of Pennsylvania. Philadelphia, PA 19104. 2: Department of Bioengineering, University of Pennsylvania. Philadelphia, PA 19104. 3: Center for Bioinformatics. University of Pennsylvania. Philadelphia, PA 19104. 4: U.S. Food and Drug Administration, Rockville, MD 20852. 5: AstraZeneca Pharmaceuticals, Mereside Alderley Park, Macclesfield, Cheshire SK1O 41G. United Kingdom. 6: Department of Genetics, University of Pennsylvania. Philadelphia, PA 19104. 7: Department of pathology and Laboratory Medicine, University of Pennsylvania. Philadelphia, PA 19104.; Source Info: 2/24/2004, Vol. 101 Issue 8, p2482; Subject Term: LAMINAR flow; Subject Term: AORTA; Subject Term: RNA; Subject Term: DNA; Subject Term: GENE expression; Subject Term: ENDOTHELIUM; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krieg, Rene C.
AU - Liotta, Lance A.
AU - Petricoin III, Emanuel F.
AU - Herrmann, Paul C.
T1 - Trapping radioactive carbon dioxide during cellular metabolic assays under standard culture conditions: description of a unique gas-capturing device
JO - Journal of Biochemical & Biophysical Methods
JF - Journal of Biochemical & Biophysical Methods
Y1 - 2004/02/27/
VL - 58
IS - 2
M3 - Article
SP - 119
SN - 0165022X
AB - Measurement of carbon dioxide levels has been employed to follow cellular metabolic reactions for quite some time. By radio-labeling substrate molecules and evaluating the radioactivity levels of the carbon dioxide released, insight into metabolic pathways can be gleaned. Currently, no carbon dioxide capturing device is available that can be used with large volume cell monolayers growing under standard conditions within a regular commercially available culture flask. In this note we describe a simple device for collecting radio-labeled carbon dioxide from a standard culture flask. The device is independent of the culture flask, but can be attached for metabolic measurements allowing cells to be grown under standard conditions prior to study. The presented design permits convenient transfer of the device between flasks without contaminating or disturbing cells growing within the flasks. Data are presented demonstrating the reproducibility of measurements made with multiple devices with different substrate concentrations and varying periods of time, ranging up to 3 h. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biochemical & Biophysical Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON dioxide
KW - METABOLISM
KW - RADIOACTIVITY
KW - PHYSIOLOGY
KW - Carbon dioxide
KW - Metabolism
KW - Physiological
KW - Radioactivity
N1 - Accession Number: 12310188; Krieg, Rene C. 1 Liotta, Lance A. 1 Petricoin III, Emanuel F. 2 Herrmann, Paul C. 1; Email Address: herrmanp@mail.nih.gov; Affiliation: 1: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10 Room 2n212, Bethesda, MD 20892, USA 2: Clinical Proteomics Program, Office of the Director, CBER, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Feb2004, Vol. 58 Issue 2, p119; Subject Term: CARBON dioxide; Subject Term: METABOLISM; Subject Term: RADIOACTIVITY; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Carbon dioxide; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Physiological; Author-Supplied Keyword: Radioactivity; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jbbm.2003.10.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Watabe, Hidenori
AU - Valencia, Julio C.
AU - Yasumoto, Ken-ichi
AU - Kushimoto, Tsuneto
AU - Ando, Hideya
AU - Muller, Jacqueline
AU - Vieira, Wilfred D.
AU - Mizoguchi, Masako
AU - Appella, Ettore
AU - Hearing, Vincent J.
T1 - Regulation of Tyrosinase Processing and Trafficking by Organellar pH and by Proteasome Activity.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/02/27/
VL - 279
IS - 9
M3 - Article
SP - 7971
EP - 7981
SN - 00219258
AB - Pigmentation of the hair, skin, and eyes of mammals results from a number of melanocyte-specific proteins that are required for the biosynthesis of melanin. Those proteins comprise the structural and enzymatic components of melanosomes, the membrane-bound organelles in which melanin is synthesized and deposited. Tyrosinase (TYR) is absolutely required for melanogenesis, but other melanosomal proteins, such as TYRP1, DCT, and gp100, also play important roles in regulating mammalian pigmentation. However, pigmentation does not always correlate with the expression of TYR mRNA/protein, and thus its function is also regulated at the post-translational level. Thus, TYR does not necessarily exist in a catalytically active state, and its post-translational activation could be an important control point for regulating melanin synthesis. In this study, we used a multidisciplinary approach to examine the processing and sorting of TYR through the endoplasmic reticulum (ER), Golgi apparatus, coated vesicles, endosomes and early melanosomes because those organelles hold the key to understanding the trafficking of TYR to melanosomes and thus the regulation of melanogenesis. In pigmented cells, TYR is trafticked through those organelles rapidly, but in a melanotic cells, TYR is retained within the ER and is eventually degraded by proteasomes. We now show that TYR can be released from the ER in the presence of protonophore or proton pump inhibitors which increase the pH of intracellular organelles, after which TYR is transported correctly to the Golgi, and then to melanosomes via the endosomal sorting system. The expression of TYRP1, which facilitates TYR processing in the ER, is down-regulated in the amelanotic cells; this is analogous to a hypopigmentary disease known as oculocutaneous albinism type 3 and further impairs melanin production. The sum of these results shows that organellar pH, proteasome activity, and down-regulation of TYRP1 expression all contribute to the lack of pigmentation in TYRpositive amelanotic melanoma cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOL oxidase
KW - CELL organelles
KW - HYDROGEN-ion concentration
KW - ANIMAL coloration
KW - MAMMALS
KW - MELANOCYTES
KW - ENDOPLASMIC reticulum
N1 - Accession Number: 12685755; Watabe, Hidenori 1 Valencia, Julio C. 1 Yasumoto, Ken-ichi 1 Kushimoto, Tsuneto 1 Ando, Hideya 1 Muller, Jacqueline 2 Vieira, Wilfred D. 1 Mizoguchi, Masako 3 Appella, Ettore 1 Hearing, Vincent J. 1; Email Address: hearing@nih.gov; Affiliation: 1: Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 2: Division of Viral Products, Food and Drug Administration, Rockville, Maryland 3: Department of Dermatology, St. Marianna University School of Medicine, Japan; Source Info: 2/27/2004, Vol. 279 Issue 9, p7971; Subject Term: PHENOL oxidase; Subject Term: CELL organelles; Subject Term: HYDROGEN-ion concentration; Subject Term: ANIMAL coloration; Subject Term: MAMMALS; Subject Term: MELANOCYTES; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 11p; Illustrations: 22 Color Photographs, 14 Black and White Photographs; Document Type: Article
L3 - 10.1074/jbc.M309714200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jae Ho Oh, Katherine S.
AU - Hai Kwan Jung, Katherine S.
AU - Yun Ju Park, Katherine S.
AU - Cheul Kyu Kim, Katherine S.
AU - Soo Youn Chung
AU - Nam Gyu Park, Katherine S.
AU - Young Won Yun, Katherine S.
AU - Dae Joong Kim
AU - Tae Youl Ha, Katherine S.
AU - Yuen Sook Song, Katherine S.
AU - Yoot Mo Lee, Katherine S.
AU - Ki wan Oh, Katherine S.
AU - Jin Tae Hong, Katherine S.
T1 - Inhibitory Effects of Ochratoxin a on Nerve Growth Factor-Induced Neurite Extension Through Downregulation of p38 Map Kinase and AP-1 Activation in Cultured Pheochromocytoma Cells.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/02/27/
VL - 67
IS - 4
M3 - Article
SP - 357
EP - 371
SN - 15287394
AB - Ochratoxin A (OTA) induces microcephaly in animals and in vitro cultured whole embryos. Inhibition of neuronal cell differentiation was proposed as underlying mechanisms responsible for OTA-induced microcephaly. Previously it was found that OTA inhibited differentiation of cultured rat embryonic midbrain cells into neurons. In this study, the influence of OTA on differentiation in PC-12 cells, a widely accepted model cells for study of neuronal differentiation was examined. Cell differentiation was assessed by measurement of neurite extension and quantified by the number of neurites extended. OTA decreased serum and nerve growth factor (NGF)-induced neurite extension in a concentration-dependent manner. Since MAP kinase and transcription factors have been implicated in cell differentiation of neuronal cells, and our previous study demonstrated that p38 MAP kinase and AP-1 are activated during PC 12 cell differentiation, the effect of OTA on NGF-induced p38 MAP kinase and transcription factor activation was examined. Co-treatment of OTA with NGF resulted in inhibition of NGF-induced p38 MAP kinase and AP-1 activation. Moreover, SB203580, a specific inhibitor of p38 MAP kinase blocked p38 MAP kinase and AP-1 activation accompanied by further inhibition of neurite extension. The present study shows that OTA inhibited cell differentiation of PC-12 cells, and this inhibitory effect may be related to inhibition of the activation of the p38 MAP kinase in conjunction with transcription factors AP-1. This finding suggests that the inhibitory effect on neuronal cell differentiation by OTA might be a mechanism responsible for OTA-induced microcephaly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCHRATOXINS
KW - NERVE Growth Factor
KW - PHEOCHROMOCYTOMA
KW - CELL differentiation
KW - MICROCEPHALY
KW - NEURONS
N1 - Accession Number: 11901062; Jae Ho Oh, Katherine S. 1 Hai Kwan Jung, Katherine S. 1 Yun Ju Park, Katherine S. 1 Cheul Kyu Kim, Katherine S. 1 Soo Youn Chung 1 Nam Gyu Park, Katherine S. 2 Young Won Yun, Katherine S. 3 Dae Joong Kim 3 Tae Youl Ha, Katherine S. 4 Yuen Sook Song, Katherine S. 5 Yoot Mo Lee, Katherine S. 5 Ki wan Oh, Katherine S. 5 Jin Tae Hong, Katherine S. 5; Affiliation: 1: Korea Food and Drug Administration 2: Department of Biotechnology and Bioengineering, Pukyong National University 3: Korea Food Research Institute 4: College of Veterinary Medicine, Korea 5: Pharmacy, Chungbuk National University Cheongju; Source Info: 2004, Vol. 67 Issue 4, p357; Subject Term: OCHRATOXINS; Subject Term: NERVE Growth Factor; Subject Term: PHEOCHROMOCYTOMA; Subject Term: CELL differentiation; Subject Term: MICROCEPHALY; Subject Term: NEURONS; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106772979
T1 - Parent's language of interview and access to care for children with special health care needs.
AU - Yu SM
AU - Nyman RM
AU - Kogan MD
AU - Huang ZJ
AU - Schwalberg RH
Y1 - 2004/03//Mar/Apr2004
N1 - Accession Number: 106772979. Language: English. Entry Date: 20040903. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Chronic Disease -- In Infancy and Childhood
KW - Health Services Accessibility
KW - Immigrants
KW - Language
KW - Adolescence
KW - Asians
KW - Child
KW - Child, Preschool
KW - Comparative Studies
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Hispanics
KW - Infant
KW - Interviews
KW - Male
KW - Odds Ratio
KW - Random Sample
KW - Telephone
KW - Whites
KW - Human
SP - 181
EP - 187
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 4
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To examine the association between the parent's language of interview and the access to care for children with special health care needs (CSHCN). METHODS: We used the 2001 National Survey of Children with Special Health Care Needs to compare socio-demographic characteristics and health care access variables among CSHCN with parents who interviewed in English and another language. Additional multivariate analyses explored the effect of language of interview on access to health care for the subgroup of Hispanic respondents. RESULTS: CSHCN with non-English-speaking parents were from less-educated and lower-income families and were more likely to lack insurance and have conditions that greatly affected their activities. These children were also more likely to have inadequate insurance (odds ratio [OR]=11.29), have an unmet need for family support services (OR=1.88), lack a personal doctor or nurse (OR=1.98), lack a usual source of care (OR=1.89), and lack family-centered care (OR=1.74). Non-English-speaking parents were more likely to report having employment consequences (OR=1.94) and spending over $500 out-of-pocket annually on the child's health care needs (OR=1.49). The likelihood of Hispanic children experiencing health care access barriers compared with non-Hispanic children was reduced when language was controlled for and several disparities between Hispanic children and other children became insignificant. CONCLUSIONS: CSHCN with non-English-speaking parents were more likely to be from disadvantaged families and to experience barriers to access than were CSHCN with English-speaking parents. Systems of care for CSHCN should consider the needs and challenges experienced by families whose primary language is not English.
SN - 1530-1567
AD - Maternal and Child Health Bureau, Division of Ressearch and Training, 5600 Fishers Ln, 18A-55, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 15018600.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Crawford, Lester
T1 - Genetic Kingdom: Reaping the Bounties of Our Biotech Future.
JO - American Enterprise
JF - American Enterprise
Y1 - 2004/03//
VL - 15
IS - 2
M3 - Article
SP - 22
EP - 23
PB - American Enterprise Institute for Public Policy Research
SN - 10473572
AB - Focuses on the use of genetically modified animals in medicine. Kinds of bioengineered animals for laboratory models; Overview of the bioengineering of cows for production of specialized milk; Assessment of the physiological risks of biotechnology.
KW - ANIMAL genetic engineering
KW - GENETIC engineering
KW - LABORATORY animals
KW - ANIMAL genetics
KW - ANIMAL biotechnology
KW - TRANSGENIC animals
N1 - Accession Number: 12475290; Crawford, Lester 1; Affiliations: 1: Deputy commissioner, U.S. Food and Drug Administration; Issue Info: Mar2004, Vol. 15 Issue 2, p22; Subject Term: ANIMAL genetic engineering; Subject Term: GENETIC engineering; Subject Term: LABORATORY animals; Subject Term: ANIMAL genetics; Subject Term: ANIMAL biotechnology; Subject Term: TRANSGENIC animals; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gottlieb, Scott
T1 - Developing the Biomedical Century: How to Get the Treatment from the Lab to the Patient.
JO - American Enterprise
JF - American Enterprise
Y1 - 2004/03//
VL - 15
IS - 2
M3 - Article
SP - 32
EP - 33
PB - American Enterprise Institute for Public Policy Research
SN - 10473572
AB - Focuses on the development of biomedical research in the U.S. Budget of the National Institutes of Health for medical products in the 1990s; Challenges to the development of medical treatments; Factors that hinder the progress of medical technologies.
KW - MEDICAL research
KW - DRUG development
KW - MEDICAL technology
KW - UNITED States
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 12475419; Gottlieb, Scott 1; Affiliations: 1: Senior adviser for medical technology, Food and Drug Administration; Issue Info: Mar2004, Vol. 15 Issue 2, p32; Subject Term: MEDICAL research; Subject Term: DRUG development; Subject Term: MEDICAL technology; Subject: UNITED States ; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106762894
T1 - Screening for gestational diabetes mellitus.
AU - Fink K
AU - Clark B
Y1 - 2004/03//3/1/2004
N1 - Accession Number: 106762894. Language: English. Entry Date: 20040806. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Diabetes Mellitus, Gestational -- Diagnosis
KW - Health Screening
KW - Adult
KW - Education, Continuing (Credit)
KW - False Positive Results
KW - Female
KW - Medical Practice, Evidence-Based
KW - Obesity -- Chemically Induced
KW - Pregnancy
KW - Pregnancy Complications
KW - Pregnancy Outcomes
KW - Risk Assessment
KW - Risk Factors
SP - 1187
EP - 1310
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 69
IS - 5
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - Putting prevention into practice: an evidence-based approach
SN - 0002-838X
AD - Program Director, US Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality
U2 - PMID: 15023021.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Macher, Abe M.
AU - Schuster-Walker, Marmie
AU - Mayne, Donna
T1 - Black Tar Heroin, Injection Drug Use, and Wound Botulism.
JO - American Jails
JF - American Jails
Y1 - 2004/03//Mar/Apr2004
VL - 18
IS - 1
M3 - Article
SP - 56
EP - 58
SN - 10560319
AB - Looks into lethal consequences of heroin abuse among injection drug users (IDUs) in the U.S. Increase of the number of IDUs in the nation; Germination of botulinum toxin; Association of wound botulism to black tar heroin.
KW - HEROIN abuse
KW - DRUG addiction
KW - INJECTIONS
KW - HEROIN
KW - DRUGS
KW - DRUG abuse
KW - UNITED States
N1 - Accession Number: 12814783; Macher, Abe M. 1 Schuster-Walker, Marmie 2 Mayne, Donna 3; Email Address: donna,mayne@fairfaxcounty.gov; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. 2: Nursing supervisor at the Prince William-Manasas Regional Adult Detention Center, Manasas, Virginia 3: Director of Medical Services at the Fairfax COunty Adult Detention Center, Virginia; Source Info: Mar/Apr2004, Vol. 18 Issue 1, p56; Subject Term: HEROIN abuse; Subject Term: DRUG addiction; Subject Term: INJECTIONS; Subject Term: HEROIN; Subject Term: DRUGS; Subject Term: DRUG abuse; Subject Term: UNITED States; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106723868
T1 - First, do no harm. Are you tired? Sleep deprivation compromises nurses' health -- and jeopardizes patients.
AU - Hughes RG
AU - Rogers AE
Y1 - 2004/03//
N1 - Accession Number: 106723868. Language: English. Entry Date: 20040416. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Fatigue
KW - Job Performance
KW - Nurses
KW - Occupational Health
KW - Patient Safety
KW - Sleep Deprivation
KW - Circadian Rhythm
KW - Health Behavior
KW - Personnel Staffing and Scheduling
KW - Shiftwork
KW - Sleep
KW - Sleep Deprivation -- Complications
SP - 36
EP - 38
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 104
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Senior Advisor on End-of-Life Care, Senior Health Scientist Administrator, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality (AHRQ)
U2 - PMID: 15108568.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MATTORANO, DINO A.
AU - KUPPER, LAWRENCE L.
AU - NYLANDER-FRENCH, LEENA A.
T1 - Estimating Dermal Exposure to Jet Fuel (Naphthalene) Using Adhesive Tape Strip Samples.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2004/03//
VL - 48
IS - 2
M3 - Article
SP - 139
EP - 146
SN - 00034878
AB - A simple, non-invasive dermal sampling technique was developed and tested on 22 human volunteers under laboratory conditions to estimate acute dermal exposure to jet fuel (JP-8). Two sites on the ventral surface of each forearm were exposed to 25 µl of JP-8 and the non-viable epidermis (stratum corneum) was sequentially tape-stripped using an adhesive tape. Samples were extracted with acetone and analyzed by gas chromatography/mass spectrometry. Analysis of the first tape strips indicated that JP-8 was rapidly removed from the stratum corneum over the 20 min study period. On average, after 5 min of exposure the first two tape strips removed 69.8% of the applied dose. The amount recovered with two tape strips decreased over time to a recovery of 0.9% 20 min after exposure. By fitting a mixed-effects linear regression model to the tape strip data, we were able to estimate accurately the amount of JP-8 initially applied. This study indicates that naphthalene has a short retention time in the human stratum corneum and that the tape stripping method, if used within 20 min of the initial exposure, can be used to measure reliably the amount of naphthalene initially in the stratum corneum due to a single exposure to jet fuel. We are currently investigating the applicability of the developed mixed-effects linear regression model to estimate acute JP-8 exposure levels based upon naphthalene measurements from tape strips collected from occupationally exposed workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - FUEL
KW - DISEASES
KW - Industrial hygiene
KW - Naphthalene
KW - Jet planes
KW - Epidermis
KW - Regression analysis
KW - dermal exposure
KW - jet fuel
KW - monitoring method
KW - naphthalene
KW - tape stripping
N1 - Accession Number: 20125625; MATTORANO, DINO A. 1,2; KUPPER, LAWRENCE L. 3; NYLANDER-FRENCH, LEENA A. 1; Email Address: leena_french@unc.edu; Affiliations: 1: Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, CB 7431, Rosenau Hall, Chapel Hill, NC 27599-7431, USA; 2: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Hazard Evaluations and Technical Assistance Branch, Cincinnati, OH 45226, USA; 3: Department of Biostatistics, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Issue Info: Mar2004, Vol. 48 Issue 2, p139; Thesaurus Term: Occupational diseases; Thesaurus Term: FUEL; Thesaurus Term: DISEASES; Thesaurus Term: Industrial hygiene; Thesaurus Term: Naphthalene; Subject Term: Jet planes; Subject Term: Epidermis; Subject Term: Regression analysis; Author-Supplied Keyword: dermal exposure; Author-Supplied Keyword: jet fuel; Author-Supplied Keyword: monitoring method; Author-Supplied Keyword: naphthalene; Author-Supplied Keyword: tape stripping; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1093/annhyg/meh003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lowe, Brian D.
T1 - Accuracy and validity of observational estimates of shoulder and elbow posture
JO - Applied Ergonomics
JF - Applied Ergonomics
Y1 - 2004/03//
VL - 35
IS - 2
M3 - Article
SP - 159
SN - 00036870
AB - This study investigated the accuracy of video-based observational posture analysis for the elbow and shoulder. Posture analyses were conducted by 28 ergonomists for four jobs presented on a traditional VHS format video recording. Estimates of posture from the observational-based methods were compared with values measured directly with an optical motion capture system. Ergonomists used categorical posture scales and a continuous visual analog scale to estimate the peak and most frequently occurring or average posture for each job. Use of a three-category scale resulted in misclassifications of peak and most frequently occurring elbow and shoulder posture with a probability averaging 30.1%. With the six-category posture scale this average probability of misclassification increased to 64.9%. Using a continuous visual analog scale peak shoulder elevation was the only posture for which the average error among ergonomists’ estimates was significantly different from zero (p<0.05) . Correlations between the estimated postures and measured postures were higher and statistically significant (p<0.05) for elbow flexion and shoulder elevation (r2 between 0.45 and 0.66) but were considerably lower and not significant (r2 between 0.03 and 0.18) for the peak and average horizontal shoulder abduction. Ergonomists’ estimates of the temporal distribution of shoulder posture, indicating the duration severity of the posture, appeared to be biased such that the percentage of the cycle time in each posture category was estimated as more uniformly distributed than the measured values indicated. [Copyright &y& Elsevier]
AB - Copyright of Applied Ergonomics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POSTURE
KW - SHOULDER
KW - ELBOW diseases
KW - STATURE
KW - Exposure assessment
KW - Musculoskeletal disorders
KW - Shoulder posture
N1 - Accession Number: 12896683; Lowe, Brian D. 1; Email Address: blowe@cdu.gov; Affiliation: 1: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226, USA; Source Info: Mar2004, Vol. 35 Issue 2, p159; Subject Term: POSTURE; Subject Term: SHOULDER; Subject Term: ELBOW diseases; Subject Term: STATURE; Author-Supplied Keyword: Exposure assessment; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Shoulder posture; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.apergo.2004.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Brumfield, Anne
AU - Miller, Gerald R.
AU - Metheny, Rebecca
AU - Cutlip, Robert G.
T1 - Comparison of mechanical properties of rat tibialis anterior tendon evaluated using two different approaches.
JO - Bio-Medical Materials & Engineering
JF - Bio-Medical Materials & Engineering
Y1 - 2004/03//
VL - 14
IS - 1
M3 - Article
SP - 13
EP - 22
PB - IOS Press
SN - 09592989
AB - Tendon injuries may result in variations of its mechanical properties. The published data of the tendon stiffness of small animals, such as mouse and rat, are exclusively obtained by measuring grip‐to‐grip (g‐t‐g) displacement. Local strain concentration and relative sliding of the specimens in the clamps might significantly affect the measured tendon deformation. In the present study, the mechanical properties of the rat tibialis anterior tendon measured using the proposed tendon mark method were compared to those evaluated using the g‐t‐g displacement method. Five male Sprague Dawley rats (∼418 g) were used in this study. For the proposed method, reference marks were made on the tendons using permanent ink. A microscope video system was customized to observe and record the tendon deformation. Pattern recognition software was developed to obtain the displacement time‐histories of the reference marks. The distance between the grips was approximately 7 mm; and the distance between the reference marks used for the data processing was approximately 5 mm. The cross‐section areas of the specimens were measured using a custom‐made slot gauge and by applying a constant compressive stress (0.15 MPa). The tendons were clamped between two custom‐made metal grips and stretched on a testing machine at a constant speed (1 mm/s) up to failure. Throughout the tests, the tendon specimens were submerged in a PBS bath at 22°C. The deformation of the specimens was evaluated using the g‐t‐g displacement method and the proposed method. The stress/strain curves obtained by using the g‐t‐g displacement can be characterized by an initial toe zone, a quasi‐linear zone, and a final failure stage. The stress/strain curves determined using the proposed method are quite different from those obtained using the g‐t‐g displacement: it has a smaller toe zone and a stress‐hardening transition, over which the tendon stiffness increases dramatically with the increasing strain. The tendon stiffness measured by using the g‐t‐g displacement method may underestimate the actual mechanical properties of tendon by approximately 43%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMECHANICS
KW - TENDONS
KW - STRAIN (Physiology)
KW - MEDICAL research
KW - RATS as laboratory animals
KW - DISPLACEMENT (Psychology)
N1 - Accession Number: 12084528; Wu, John Z. 1; Email Address: jwu@cdc.gov Brumfield, Anne 1 Miller, Gerald R. 1 Metheny, Rebecca 1 Cutlip, Robert G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: 2004, Vol. 14 Issue 1, p13; Subject Term: BIOMECHANICS; Subject Term: TENDONS; Subject Term: STRAIN (Physiology); Subject Term: MEDICAL research; Subject Term: RATS as laboratory animals; Subject Term: DISPLACEMENT (Psychology); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106680262
T1 - Clinical governance in a Welsh health authority.
AU - Morgan G
AU - John N
AU - Sandifer Q
Y1 - 2004/03//2004 Mar
N1 - Accession Number: 106680262. Language: English. Entry Date: 20040514. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Europe; Health Services Administration; Peer Reviewed; UK & Ireland.
KW - Clinical Governance
KW - National Health Programs -- Wales
KW - Collaboration
KW - Health Policy
KW - Wales
SP - 4
EP - 6
JO - Clinical Governance Bulletin
JF - Clinical Governance Bulletin
JA - CLIN GOVERNANCE BULL
VL - 4
IS - 6
PB - Royal Society of Medicine Press Limited
AB - In Wales, top-down guidance on clinical governance was issued. The guidance provided a platform for the delivery of the clinical governance agenda.Health authorities in Wales, such as lechyd Morgannwg, took a strategic role in delivering the agenda, which informed the development of the local Health Improvement Programme and other activities.Informal discussions between professionals in joint fora can facilitate the sharing of knowledge and encourage good practice.Good practice can be further developed within the reorganised NHS in Wales.
SN - 1470-9023
AD - Public Health Practitioner, National Public Health Service for Wales, Mid and West Wales Region, 36 Orchard Street, Swansea SA1 5AQ; gareth.morgan@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Boulanger, L. Lucy
AU - Ettestad, Paul
AU - Fogarty, John D.
AU - Dennis, David T.
AU - Romig, Donald
AU - Mertz, Gregory
T1 - Gentamicin and Tetracyclines for the Treatment of Human Plague: Review of 75 Cases in New Mexico, 1985--1999.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/03//3/1/2004
VL - 38
IS - 5
M3 - Article
SP - 663
EP - 669
SN - 10584838
AB - Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern. We evaluated the efficacy of gentamicin and tetracyclines for treating human plague. A medical record review was conducted on all 75 patients with plague who were reported in New Mexico during 1985-1999. Fifty patients were included in an analysis that compared streptomycin-treated patients (n = 14) with those treated with gentamicin and/or a tetracycline (n = 36). The mean numbers of fever days, hospital days, and complications and the number of deaths did not differ between patients treated with streptomycin and those treated with gentamicin. One patient who received tetracycline alone experienced a serious complication. Gentamicin alone or in combination with a tetracycline was as efficacious as streptomycin for treating human plague. The efficacy of a tetracycline alone could not be determined from the study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bioterrorism
KW - Epidemics
KW - Plague
KW - Gentamicin
KW - Tetracyclines
KW - New Mexico
KW - United States
N1 - Accession Number: 12353949; Boulanger, L. Lucy 1,2; Email Address: lucyjohn@hotmail.com; Ettestad, Paul 3; Fogarty, John D. 2,4; Dennis, David T. 5; Romig, Donald 6; Mertz, Gregory 1; Affiliations: 1: Department of Internal Medicine, Division of Infectious Diseases; 2: Indian Health Service, United States Public Health Service, New Mexico; 3: Office of Epidemiology, New Mexico Department of Health; 4: Department of Family Medicine and Masters in Public Health Program, University of New Mexico; 5: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Colorado; 6: Private practice, Santa Fe; Issue Info: 3/1/2004, Vol. 38 Issue 5, p663; Thesaurus Term: Bioterrorism; Thesaurus Term: Epidemics; Thesaurus Term: Plague; Subject Term: Gentamicin; Subject Term: Tetracyclines; Subject: New Mexico; Subject: United States; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Doty, Richard L.
AU - Cometto-muñiz, J. Enrique
AU - Jalowaysk, Alfredo A.
AU - Dalton, Pamela
AU - Kendal-reed, Martin
AU - Hodgson, Michael
T1 - Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans.
JO - Critical Reviews in Toxicology
JF - Critical Reviews in Toxicology
Y1 - 2004/03//Mar/Apr2004
VL - 34
IS - 2
M3 - Article
SP - 85
EP - 142
PB - Taylor & Francis Ltd
SN - 10408444
AB - Accurate assessment of upper respiratory tract and ocular irritation is critical for identifying and remedying problems related to overexposure to volatile chemicals, as well as for establishing parameters of irritation useful for regulatory purposes. This article (a) describes the basic anatomy and physiology of the human upper respiratory tract and ocular mucosae, (b) discusses how airborne chemicals induce irritative sensations, and (c) reviews practical means employed for assessing such phenomena, including psychophysical (e.g., threshold and suprathreshold perceptual measures), physiological (e.g., cardiovascular responses), electrophysiological (e.g., event-related potentials), and imaging (e.g., magnetic resonance imaging) techniques. Although traditionally animal models have been used as the first step in assessing such irritation, they are not addressed here since (a) there are numerous reviews available on this topic and (b) many rodents and rabbits are obligate nose breathers whose nasal passages differ considerably from those of humans, potentially limiting generalization of animal-based data to humans. A major goal of this compendium is to inform the reader of procedures for assessing irritation in humans and to provide information of value in the continued interpretation and development of empirical databases upon which future reasoned regulatory health decisions can be made. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Electrophysiology
KW - Glossopharyngeal nerve
KW - Magnetic resonance imaging
KW - Trigeminal nerve
KW - Vagus nerve
KW - cilia
KW - electrophysiology
KW - glossopharyngeal nerve
KW - irritation
KW - magnetic resonance imaging
KW - psychophysics
KW - rhinomanometry
KW - thresholds
KW - trigeminal nerve
KW - vagus nerve.
N1 - Accession Number: 13025271; Doty, Richard L. 1; Email Address: doty@mail.med.upenn.edu; Cometto-muñiz, J. Enrique 2; Jalowaysk, Alfredo A. 2; Dalton, Pamela 3; Kendal-reed, Martin 4; Hodgson, Michael 5; Affiliations: 1: University of Pennsylvania, Philadelphia, PA, USA; 2: University of California, San Diego, CA, USA; 3: Monell Chemical Senses Center, Philadelphia, PA, USA; 4: Florida State University, Tallahassee, FL, USA; 5: National Institute of Occupational Safety and Health, Bethesda, MD, USA; Issue Info: Mar/Apr2004, Vol. 34 Issue 2, p85; Subject Term: Electrophysiology; Subject Term: Glossopharyngeal nerve; Subject Term: Magnetic resonance imaging; Subject Term: Trigeminal nerve; Subject Term: Vagus nerve; Author-Supplied Keyword: cilia; Author-Supplied Keyword: electrophysiology; Author-Supplied Keyword: glossopharyngeal nerve; Author-Supplied Keyword: irritation; Author-Supplied Keyword: magnetic resonance imaging; Author-Supplied Keyword: psychophysics; Author-Supplied Keyword: rhinomanometry; Author-Supplied Keyword: thresholds; Author-Supplied Keyword: trigeminal nerve; Author-Supplied Keyword: vagus nerve.; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 58p; Document Type: Article
L3 - 10.1080/10408440490269586
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Smith, Robert M. M.
AU - Drobniewski, Francis
AU - Gibson, Andrea
AU - Montague, John D. E.
AU - Logan, Margaret N.
AU - Hunt, David
AU - Hewinson, Glyn
AU - Salmon, Roland L.
AU - O'Neill, Brian
T1 - Mycobacterium bovis Infection, United Kingdom.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/03//
VL - 10
IS - 3
M3 - Article
SP - 539
EP - 541
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We describe the first documented spillover of bovine tuberculosis from animals into the human population of the United Kingdom since the resurgence of the disease in cattle in the country. This finding suggests that there may be a small risk for transmission to humans, making continued vigilance particularly necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases -- Transmission
KW - Tuberculosis in cattle
KW - Mycobacterial diseases
KW - Disease relapse
KW - Great Britain
N1 - Accession Number: 12525662; Smith, Robert M. M. 1; Email Address: robert.smith@nphs.wales.nhs.uk; Drobniewski, Francis 2; Gibson, Andrea 2; Montague, John D. E. 3; Logan, Margaret N. 4; Hunt, David 5; Hewinson, Glyn 6; Salmon, Roland L. 1; O'Neill, Brian 7; Affiliations: 1: National Public Health Service for Wales, Cardiff, United Kingdom; 2: Health Protection Agency, London, United Kingdom; 3: Department for Environment, Food and Rural Affairs, Gloucestershire, United Kingdom; 4: Gloucester Hospitals National Health Service Trust (formerly Gloucester Public Health Laboratory), Gloucester, United Kingdom; 5: Health Protection Agency (West Midlands) Regional Surveillance Unit, Birmingham, United Kingdom; 6: Veterinary Laboratories Agency, Weybridge, United Kingdom; 7: Gloucestershire Health Protection Unit, Gloucester, United Kingdom; Issue Info: Mar2004, Vol. 10 Issue 3, p539; Thesaurus Term: Communicable diseases -- Transmission; Subject Term: Tuberculosis in cattle; Subject Term: Mycobacterial diseases; Subject Term: Disease relapse; Subject: Great Britain; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morgan, Gareth
T1 - Aspirin and colorectal cancer?
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2004/03//
VL - 14
IS - 1
M3 - Article
SP - 105
EP - 106
SN - 11011262
AB - This paper evaluates aspirin in the reduction of colorectal cancer risk against the nine causality criteria suggested by Bradford-Hill in 1965. Although some questions remain, the evidence is suggestive of a reduction by perhaps 20-30%. Aspirin could make important contributions to public health programmes given that it reduces cardiovascular disease risk and is relatively safe. It is appropriate for bodies such as the World Health Organisation and national governments to begin to consider the future use of aspirin for the reduction of two major sources of death and disability. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Public Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPIRIN
KW - CARDIOVASCULAR diseases
KW - PUBLIC health
KW - COLON cancer
KW - ANALGESICS
KW - aspirin
KW - Bradford-Hill
KW - cardiovascular disease
KW - colorectal cancer
N1 - Accession Number: 13503850; Morgan, Gareth 1; Email Address: gareth.morgan@nphs.wales.nhs.uk; Affiliation: 1: Public Health Practitioner, National Public Health Service for Wales, 36 Orchard Street, Swansea SA1 5AQ, UK; Source Info: Mar2004, Vol. 14 Issue 1, p105; Subject Term: ASPIRIN; Subject Term: CARDIOVASCULAR diseases; Subject Term: PUBLIC health; Subject Term: COLON cancer; Subject Term: ANALGESICS; Author-Supplied Keyword: aspirin; Author-Supplied Keyword: Bradford-Hill; Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: colorectal cancer; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106650378
T1 - Aspirin and colorectal cancer?
AU - Morgan G
Y1 - 2004/03//
N1 - Accession Number: 106650378. Language: English. Entry Date: 20041008. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Bradford-Hill A. The environment and disease: association or causation? PROC R SOC MED 1965; 9: 295-300. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9204966.
KW - Aspirin -- Therapeutic Use
KW - Colorectal Neoplasms -- Prevention and Control
SP - 105
EP - 106
JO - European Journal of Public Health
JF - European Journal of Public Health
JA - EUR J PUBLIC HEALTH
VL - 14
IS - 1
PB - Oxford University Press / USA
AB - This paper evaluates aspirin in the reduction of colorectal cancer risk against the nine causality criteria suggested by Bradford-Hill in 1965. Although some questions remain, the evidence is suggestive of a reduction by perhaps 20-30%. Aspirin could make important contributions to public health programmes given that it reduces cardiovascular disease risk and is relatively safe. It is appropriate for bodies such as the World Health Organisation and national governments to begin to consider the future use of aspirin for the reduction of two major sources of death and disability.
SN - 1101-1262
AD - Public Health Practitioner, National Public Health Service for Wales, 36 Orchard St, Swansea SA1 5AQ, UK; gareth.morgan@nphs.wales.nhs.uk
U2 - PMID: 15080402.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Morgan, Gareth
T1 - Aspirin and colorectal cancer?
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2004/03//
VL - 14
IS - 1
M3 - Article
SP - 105
EP - 106
SN - 11011262
AB - This paper evaluates aspirin in the reduction of colorectal cancer risk against the nine causality criteria suggested by Bradford-Hill in 1965. Although some questions remain, the evidence is suggestive of a reduction by perhaps 20-30%. Aspirin could make important contributions to public health programmes given that it reduces cardiovascular disease risk and is relatively safe. It is appropriate for bodies such as the World Health Organisation and national governments to begin to consider the future use of aspirin for the reduction of two major sources of death and disability. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Public Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPIRIN
KW - CARDIOVASCULAR diseases
KW - PUBLIC health
KW - COLON cancer
KW - ANALGESICS
KW - aspirin
KW - Bradford-Hill
KW - cardiovascular disease
KW - colorectal cancer
N1 - Accession Number: 13503850; Morgan, Gareth 1; Email Address: gareth.morgan@nphs.wales.nhs.uk; Source Information: Mar2004, Vol. 14 Issue 1, p105; Subject: ASPIRIN; Subject: CARDIOVASCULAR diseases; Subject: PUBLIC health; Subject: COLON cancer; Subject: ANALGESICS; Author-Supplied Keyword: aspirin; Author-Supplied Keyword: Bradford-Hill; Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: colorectal cancer; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Smith, J. S.
AU - Tian, J.
AU - Muller, J.
AU - Byrnes, A. P.
T1 - Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease.
JO - Gene Therapy
JF - Gene Therapy
Y1 - 2004/03//
VL - 11
IS - 5
M3 - Article
SP - 431
EP - 438
PB - Nature Publishing Group
SN - 09697128
AB - When adenovirus vectors are injected intravenously, most of the virions are quickly taken up by the reticuloendothelial system, primarily by the liver macrophages known as Kupffer cells. However, little is known about the behavior of adenovirus vectors when there is pre-existing liver disease. To study this, we examined the biodistribution of intravenously injected vector in a rat model of cirrhosis induced by bile duct ligation. Using quantitative PCR and fluorescently tagged adenovirus vectors, we observed a significant reduction in vector uptake by the cirrhotic liver and increased accumulation in the lungs. Immunocytochemistry and electron microscopy demonstrated that this was due to changes in the reticuloendothelial system, with the vector being taken up by large numbers of pulmonary intravascular macrophages in the lungs of cirrhotic rats. Interestingly, expression of vector-encoded luciferase was significantly reduced in the livers of cirrhotic rats, but was not increased in the lungs. These data demonstrate that the biodistribution of adenovirus vectors in rats is altered by cirrhosis, which suggests the possibility that these vectors might behave unexpectedly in patients with pre-existing liver conditions, particularly since pulmonary reticuloendothelial changes are known to occur in human disease.Gene Therapy (2004) 11, 431-438. doi:10.1038/sj.gt.3302149 [ABSTRACT FROM AUTHOR]
AB - Copyright of Gene Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER diseases
KW - ADENOVIRUSES
KW - RETICULO-endothelial system
KW - KUPFFER cells
KW - CIRRHOSIS of the liver
KW - RATS as laboratory animals
KW - adenovirus
KW - biodistribution
KW - cirrhosis.
KW - pulmonary intravascular macrophage
KW - reticuloendothelial system
N1 - Accession Number: 12324681; Smith, J. S. 1 Tian, J. 1 Muller, J. 2 Byrnes, A. P. 1; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. 2: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.; Source Info: Mar2004, Vol. 11 Issue 5, p431; Subject Term: LIVER diseases; Subject Term: ADENOVIRUSES; Subject Term: RETICULO-endothelial system; Subject Term: KUPFFER cells; Subject Term: CIRRHOSIS of the liver; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: adenovirus; Author-Supplied Keyword: biodistribution; Author-Supplied Keyword: cirrhosis.; Author-Supplied Keyword: pulmonary intravascular macrophage; Author-Supplied Keyword: reticuloendothelial system; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1038/sj.gt.3302149
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12324681&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirtava, A.
AU - Crudder, S.
AU - Dilley, A.
AU - Lally, C.
AU - Evatt, B.
T1 - Trends in clinical management of women with von Willebrand disease: a survey of 75 women enrolled in haemophilia treatment centres in the United States.
JO - Haemophilia
JF - Haemophilia
Y1 - 2004/03//
VL - 10
IS - 2
M3 - Article
SP - 158
EP - 161
PB - Wiley-Blackwell
SN - 13518216
AB - To assess the management of women with von Willebrand disease( vWD) in an Heamophilia Treatment Center (HTC) setting. A total of 75 women with vWd who were registered in HTCs in the United States participated in this study. A telephone interview elicited information about symptoms pertaining to bleeding disorders, diagnostic issues, referral patterns, treatment modalities before and after the enrollment in the HTC, HTC services provided, and satisfaction with care in the HTC. Menorrhagia was the most commonly reported symptom (84%). The average time from the first symptom until clinician recognition was 16 years (range 0-39). In HTC, DDAVP was the most commonly used drug (31%). Of the 75 women, 71 reported a strong positive opinion and satisfaction about their care in the HTCs. Women with VWD were typically diagnosed with the condition well into adulthood, in spite of the fact that majority of them experienced several bleeding symptoms beginning in early childhood. In general an HTC setting is appropriate for management of women with bleeding disorders. Diagnosis, treatment and education provided in the HTCs were viewed positively by those surveyed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Haemophilia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOPHILIA
KW - VON Willebrand disease
KW - GENETIC disorders
KW - HEMORRHAGIC diseases
KW - BLOOD coagulation disorders
KW - UNITED States
N1 - Accession Number: 12255641; Kirtava, A. 1; Email Address: akirtava@cdc.gov Crudder, S. 1 Dilley, A. 1 Lally, C. 1 Evatt, B. 1; Affiliation: 1: Division of AIDS, STD, and Laboratory Research, national Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, USA; Source Info: Mar2004, Vol. 10 Issue 2, p158; Subject Term: HEMOPHILIA; Subject Term: VON Willebrand disease; Subject Term: GENETIC disorders; Subject Term: HEMORRHAGIC diseases; Subject Term: BLOOD coagulation disorders; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
L3 - 10.1046/j.1351-8216.2003.00832.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hellinger, Fred J.
T1 - HIV Patients in the HCUP Database: A Study of Hospital Utilization and Costs.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2004///Spring2004
VL - 41
IS - 1
M3 - Article
SP - 95
EP - 105
SN - 00469580
AB - This study examines the utilization of hospital care by HlV patients in all hospitals in eight states (California, Colorado, Florida, Kansas, New Jersey, New York, Pennsylvania, and South Carolina), and examines the cost of hospital care for HIV patients in six of these states (California, Colorado, Kansas, New Jersey, New York, and South Carolina). The eight states in the sample account for more than 52% of all persons living with AIDS in the United States; the six states account for 39%. The unit of observation in both studies is a hospital admission by a patient with HIV. Hospital data were obtained from the Healthcare Cost and Utilization Project (HCUP), State Inpatient Database (SID), which is maintained by the Agency for Healthcare Research and Quality (AHRQ). The HCUP contains hospital discharge data and is a federal/state/industry partnership to build a multistate health care data system. Using multivariate analytic techniques and data from 2000, results indicate that cost and length of a hospital stay vary significantly across states after accounting for a patient's gender, insurance type, race, age, and number of diagnoses, as well as the teaching status and ownership category of the hospital. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL utilization
KW - HIV-positive persons
KW - AIDS (Disease)
KW - MEDICAL care costs
KW - SOCIODEMOGRAPHIC factors
KW - UNITED States
N1 - Accession Number: 13585247; Hellinger, Fred J. 1; Email Address: fhelling@ahrq.gov; Affiliations: 1: Economist, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality; Issue Info: Spring2004, Vol. 41 Issue 1, p95; Subject Term: HOSPITAL utilization; Subject Term: HIV-positive persons; Subject Term: AIDS (Disease); Subject Term: MEDICAL care costs; Subject Term: SOCIODEMOGRAPHIC factors; Subject: UNITED States; Number of Pages: 11p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106775469
T1 - HIV patients in the HCUP database: a study of hospital utilization and costs.
AU - Hellinger FJ
Y1 - 2004///Spring2004
N1 - Accession Number: 106775469. Language: English. Entry Date: 20040910. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Databases
KW - Health Facility Costs
KW - HIV Infections -- Economics
KW - Hospitals -- Utilization
KW - Informatics
KW - Public Health
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Comparative Studies
KW - Confidence Intervals
KW - Data Analysis Software
KW - Demography
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - HIV Infections -- Epidemiology -- United States
KW - HIV Infections -- Therapy
KW - Length of Stay -- Economics
KW - Male
KW - Patient Admission -- Economics
KW - Regression
KW - Surveys
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - Human
SP - 95
EP - 105
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 41
IS - 1
PB - Sage Publications Inc.
AB - This study examines the utilization of hospital care by HIV patients in all hospitals in eight states (California, Colorado, Florida, Kansas, New Jersey, New York, Pennsylvania, and South Carolina), and examines the cost of hospital care for HIV patients in six of these states (California, Colorado, Kansas, New Jersey, New York, and South Carolina). The eight states in the sample account for more than 52% of all persons living with AIDS in the United States; the six states account for 39%. The unit of observation in both studies is a hospital admission by a patient with HIV. Hospital data were obtained from the Healthcare Cost and Utilization Project (HCUP), State Inpatient Database (SID), which is maintained by the Agency for Healthcare Research and Quality (AHRQ). The HCUP contains hospital discharge data and is a federal/state/industry partnership to build a multistate health care data system. Using multivariate analytic techniques and data from 2000, results indicate that cost and length of a hospital stay vary significantly across states after accounting for a patient's gender, insurance type, race, age, and number of diagnoses, as well as the teaching status and ownership category of the hospital.
SN - 0046-9580
AD - Agency for Healthcare Research and Quality, CDOM, Suite 5315, 540 Gaither Road, Rockville, MD 20850; fhelling@ahrq.gov
U2 - PMID: 15224963.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mason, Brendan W.
AU - Howard, Anthony J.
T1 - Fusidic acid resistance in community isolates of methicillin susceptible Staphylococcus aureus and the use of topical fusidic acid: a retrospective case–control study
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2004/03//
VL - 23
IS - 3
M3 - Article
SP - 299
SN - 09248579
AB - Resistance to fusidic acid among community methicillin susceptible Staphylococcus aureus (MSSA) isolates in the United Kingdom and prescriptions for fusidic acid have both doubled over the past 6 years. A retrospective case–control study was undertaken to test the hypothesis that the use of topical fusidic acid is associated with the isolation of resistant organisms. A statistically significant association was found between fusidic acid resistance in MSSA isolates and exposure to topical fusidic acid (odds ratio: 2.77, 95%CI 1.01–7.93, P=0.027 ). This study demonstrates for the first time an association between the use of topical fusidic acid and resistance at the individual patient level and supports the hypothesis that the observed increase in resistance is causally associated with the increased use of topical fusidic acid. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Methicillin
KW - Staphylococcus aureus
KW - Patients
KW - Drug resistance
KW - Great Britain
KW - Antimicrobial resistance
KW - Case–control study
KW - Fusidic acid
KW - Methicillin susceptible Staphylococcus aureus
N1 - Accession Number: 12379035; Mason, Brendan W. 1; Email Address: brendan.mason@nphs.wales.nhs.uk; Howard, Anthony J. 2; Affiliations: 1: National Public Health Service for Wales, Communicable Disease Surveillance Centre (Wales), Abton House, Wedal Road, Cardiff CF14 3QX, UK; 2: Department of Medical Microbiology and National Public Health Service for Wales Laboratory, University Hospital of Wales, Cardiff CF14 4XW, UK; Issue Info: Mar2004, Vol. 23 Issue 3, p299; Thesaurus Term: Anti-infective agents; Subject Term: Methicillin; Subject Term: Staphylococcus aureus; Subject Term: Patients; Subject Term: Drug resistance; Subject: Great Britain; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Case–control study; Author-Supplied Keyword: Fusidic acid; Author-Supplied Keyword: Methicillin susceptible Staphylococcus aureus; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2003.09.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12379035&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yoshitomi, Ken
T1 - Short communication Alkaline phosphatase activity in cheeses measured by fluorometry.
JO - International Journal of Food Science & Technology
JF - International Journal of Food Science & Technology
Y1 - 2004/03//
VL - 39
IS - 3
M3 - Article
SP - 349
EP - 353
PB - Wiley-Blackwell
SN - 09505423
AB - Presents results of an investigation into assaying alkaline phosphatase activity in cheese using 4UMP as a substrate. Comparison between fluorometric and colorimetric determinations; Correlation of fluorometric determinations of ALP activity with colorimetric values.
KW - ALKALINE phosphatase
KW - PHOSPHATASES
KW - ZINC enzymes
KW - CHEESE
KW - FLUORIMETER
KW - ESTERASES
N1 - Accession Number: 12254978; Yoshitomi, Ken 1; Email Address: ken.yoshitomi@fda.gov; Affiliation: 1: US Food and Drug Administration, Pacific Regional Laboratory Northwest, Seafood Products Research Center, USA; Source Info: Mar2004, Vol. 39 Issue 3, p349; Subject Term: ALKALINE phosphatase; Subject Term: PHOSPHATASES; Subject Term: ZINC enzymes; Subject Term: CHEESE; Subject Term: FLUORIMETER; Subject Term: ESTERASES; NAICS/Industry Codes: 311513 Cheese Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1365-2621.2004.00786.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Heinze, Thomas M.
AU - Beger, Richard
AU - Pothuluri, Jairaj V.
AU - Cerniglia, Carl E.
T1 - A kinetic study on the degradation of erythromycin A in aqueous solution
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2004/03//
VL - 271
IS - 1/2
M3 - Article
SP - 63
SN - 03785173
AB - The pH is a critical factor determining the rate of the degradation of erythromycin A in aqueous solutions. However, the kinetics of the acid- and base-catalyzed degradation is still uncertain. This study used a sensitive coulometric detection method to determine concentrations of erythromycin A and its degradation products. To determine the buffer-independent rate constants, sodium acetate (0.05–0.2 M) and Tris–HCl (0.1–0.5 M) were used in a pH range of 3.5–5.5 and 7.0–9.0, respectively. In acidic conditions, anhydroerythromycin A appeared to be produced directly through an internal dehydration of erythromycin A-6,9-hemiketal which simultaneously established an equilibrium with erythromycin A enol ether on the other hand. In weakly alkaline conditions, hydroxide ion appeared to catalyze the hydrolysis of the lactonyl ester bond of erythromycin A-6,9-hemiketal by the pseudo-first-order kinetics, and the C13→C11 translactonization and internal dehydration reactions subsequently occurred to form pseudoerythromycin A enol ether. We suggest here a predictive model for reasonable interpretation of the kinetics of erythromycin A degradation in aqueous solutions, in which the observed rate constant was expressed by the sum of the partial reaction rate constants for the acid- and base-catalyzed degradation of erythromycin A-6,9-hemiketal as a function of pH in a range of 3.0–10.0. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROMYCIN
KW - BIODEGRADATION
KW - CATALYSIS
KW - ACID-base chemistry
KW - Acid-catalysis
KW - Base-catalysis
KW - Erythromycin
KW - Kinetics
N1 - Accession Number: 12170022; Kim, Yong-Hak 1 Heinze, Thomas M. 1 Beger, Richard 1 Pothuluri, Jairaj V. 1 Cerniglia, Carl E.; Email Address: ccerniglia@nctr.fda.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA; Source Info: Mar2004, Vol. 271 Issue 1/2, p63; Subject Term: ERYTHROMYCIN; Subject Term: BIODEGRADATION; Subject Term: CATALYSIS; Subject Term: ACID-base chemistry; Author-Supplied Keyword: Acid-catalysis; Author-Supplied Keyword: Base-catalysis; Author-Supplied Keyword: Erythromycin; Author-Supplied Keyword: Kinetics; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.ijpharm.2003.10.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lutz, T. J.
AU - Homce, G. T.
T1 - Remote control of an agricultural tractor in SAE field upset tests.
JO - International Journal of Vehicle Design
JF - International Journal of Vehicle Design
Y1 - 2004/03//
VL - 34
IS - 3
M3 - Article
SP - 286
EP - 296
SN - 01433369
AB - Research by the National Institute for Occupational Safety and Health (NIOSH), Division of Safety Research in Morgantown, West Virginia is addressing the problem of injuries due to agricultural tractor rollovers, and improvements to rollover protective structures (ROPS). As part of this research, the NIOSH, Pittsburgh Research Laboratory modified a Ford model 4600 agricultural tractor for remote control operation, and used this tractor to conduct SAE field upset tests. Modifications to the tractor involved installing a protective framework, electrical actuators for fuel, brake, clutch, and steering controls, and a radio link for remote operation. The tractor has been used to complete over 30 total side and back upset tests, with no failures of the remote control system. These tests have allowed NIOSH researchers to study the performance of currently available ROPS, use this information for the development of improved ROPS designs, and test a NIOSH-developed prototype automatically deploying ROPS. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Vehicle Design is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL safety
KW - FARM tractors
KW - AGRICULTURAL equipment -- Rollover protective structures
KW - ROLLOVER protective structures (Machinery)
KW - REMOTE control
KW - agricultural safety
KW - field upset test
KW - overturn
KW - remote control
KW - rollover
KW - ROPS
KW - SAE J2194
KW - tractor
KW - tractor safety
N1 - Accession Number: 14792298; Lutz, T. J. 1; Email Address: tcl9@cdc.gov; Homce, G. T. 1; Email Address: gdh3@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh, PA 15236-0070, USA; Issue Info: 2004, Vol. 34 Issue 3, p286; Thesaurus Term: INDUSTRIAL safety; Subject Term: FARM tractors; Subject Term: AGRICULTURAL equipment -- Rollover protective structures; Subject Term: ROLLOVER protective structures (Machinery); Subject Term: REMOTE control; Author-Supplied Keyword: agricultural safety; Author-Supplied Keyword: field upset test; Author-Supplied Keyword: overturn; Author-Supplied Keyword: remote control; Author-Supplied Keyword: rollover; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: SAE J2194; Author-Supplied Keyword: tractor; Author-Supplied Keyword: tractor safety; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Letarte, Simon
AU - Morency, Daniel
AU - Wilkes, J.
AU - Bertrand, Michel J.
T1 - Py-MAB-Tof detection and Identification of microorganisms in urine
JO - Journal of Analytical & Applied Pyrolysis
JF - Journal of Analytical & Applied Pyrolysis
Y1 - 2004/03//
VL - 71
IS - 1
M3 - Article
SP - 13
SN - 01652370
AB - Rapid detection and identification of bacteria and other microorganisms has become a field where new analytical methods are needed. An approach, based on the use of pyrolysis coupled to mass spectrometry (Py-MS), for the detection and identification of bacteria in urine and other aqueous samples is described. In this procedure, the sample is placed on a direct insertion probe and pyrolysis is conducted directly into the ion source of the mass spectrometer. Ionization is achieved with a metastable atom bombardment source (MAB). In contrast to electron ionization, this novel ionization source, by providing discrete ionization energies, allows selective ionization and control over fragmentation. The MAB source is coupled to a time-of-flight (Tof) mass analyzer that provides high sensitivity and fast spectral acquisition. Experiments conducted with a number of uropathogenic bacteria, such as Escherichia coli, Citrobacter freundii, Proteus mirabilis and Pseudomonas aeruginosa, reveal that they provide discernable fingerprints when analyzed in urine samples by Py-MAB-Tof. Results can be obtained in minutes and the sensitivity is such that 104 bacteria on the pyrolysis probe are required for analysis. [Copyright &y& Elsevier]
AB - Copyright of Journal of Analytical & Applied Pyrolysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROORGANISMS -- Detection
KW - IDENTIFICATION of bacteria
KW - URINE
KW - PYROLYSIS
KW - Bacteria
KW - Diagnostic
KW - MAB
KW - Mass spectrometry
KW - Microorganisms
KW - Pyrolysis
KW - Urine
N1 - Accession Number: 12740529; Letarte, Simon 1 Morency, Daniel 2 Wilkes, J. 3 Bertrand, Michel J. 1; Email Address: michelj.bertrand@sympatico.ca; Affiliation: 1: Department of Chemistry, Regional Center for Mass Spectrometry, University of Montreal, C.P. 6128, Montreal, Quebec, Canada H3C 3J7 2: Department of Microbiology and Immunology, University of Montreal, C.P. 6128, Montreal, Quebec, Canada H3C 3J7 3: National Center for Toxicological Research, Jefferson, AK, USA; Source Info: Mar2004, Vol. 71 Issue 1, p13; Subject Term: MICROORGANISMS -- Detection; Subject Term: IDENTIFICATION of bacteria; Subject Term: URINE; Subject Term: PYROLYSIS; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Diagnostic; Author-Supplied Keyword: MAB; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Microorganisms; Author-Supplied Keyword: Pyrolysis; Author-Supplied Keyword: Urine; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/S0165-2370(03)00095-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, Mary W.
AU - Brewer, Vickery A.
AU - Williams, Kristina M.
AU - Westphal, Carmen D.
AU - Heeres, James T.
T1 - Preparation of Peanut Butter Suspension for Determination of Peanuts Using Enzyme-Linked Immunoassay Kits.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/03//Mar/Apr2004
VL - 87
IS - 2
M3 - Article
SP - 424
EP - 428
SN - 10603271
AB - Studies the preparation of peanut butter suspension for the determination of peanuts using enzyme-linked immunoassay kits. Specific protein constituents in the peanuts; Qualities of the suspension that makes it applicable for adding to ice cream, cookies, breakfast cereals and chocolate; Implications on food composition and additives.
KW - IMMUNOASSAY
KW - IMMUNOGLOBULINS
KW - SUSPENSIONS (Chemistry)
KW - PEANUT butter
KW - FOOD contamination
KW - CONTAMINATION (Technology)
N1 - Accession Number: 13263685; Trucksess, Mary W. 1; Email Address: mary.trucksess@cfsan.fda.gov Brewer, Vickery A. 1 Williams, Kristina M. 1 Westphal, Carmen D. 1 Heeres, James T. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition 2: Joint Institute for Food Safety and Applied Nutrition, University of Maryland; Source Info: Mar/Apr2004, Vol. 87 Issue 2, p424; Subject Term: IMMUNOASSAY; Subject Term: IMMUNOGLOBULINS; Subject Term: SUSPENSIONS (Chemistry); Subject Term: PEANUT butter; Subject Term: FOOD contamination; Subject Term: CONTAMINATION (Technology); NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mossoba, Magdi M.
AU - Yurawecz, Martin P.
AU - Delmonte, Pierluigi
AU - Kramer, John K.G.
T1 - Overview of Infrared Methodologies for trans Fat Determination.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/03//Mar/Apr2004
VL - 87
IS - 2
M3 - Article
SP - 540
EP - 544
SN - 10603271
AB - Presents an overview of infrared methodologies for the determination of trans fatty acids. Reasons why the quantitation and identification of trans fatty acid isomers is difficult; Presence of trans fatty acids in food products that contain commercially hydrogenated fats; Modifications to the procedure to eliminate any adverse impact on accuracy arising from interfering minor food components.
KW - INFRARED spectroscopy
KW - TRANS fatty acids
KW - STEREOISOMERS
KW - FOOD
KW - SPECTRUM analysis
N1 - Accession Number: 13263700; Mossoba, Magdi M. 1; Email Address: mmossoba@cfsan.fdsa.gov Yurawecz, Martin P. 2 Delmonte, Pierluigi 2 Kramer, John K.G. 3; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements 3: Agriculture and Agri-Food Canada, Food Research Program, Canada; Source Info: Mar/Apr2004, Vol. 87 Issue 2, p540; Subject Term: INFRARED spectroscopy; Subject Term: TRANS fatty acids; Subject Term: STEREOISOMERS; Subject Term: FOOD; Subject Term: SPECTRUM analysis; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cruz-Hernandez, Cristina
AU - Deng, Zeyuan
AU - Jianqiang Zhou
AU - Hill, Arthur R.
AU - Yurawecz, Martin P.
AU - Delmonte, Pierluigi
AU - Mossoba, Magdi M.
AU - Dugan, Michael E.R.
AU - Kramer, John K.G.
T1 - Methods for Analysis of Conjugated Linoleic Acids and trans-18:1 Isomers in Dairy Fats by Using a Combination of Gas Chromatography, Silver-Ion Thin-Layer Chromatography/Gas Chromatography, and Silver-Ion Liquid Chromatography.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/03//Mar/Apr2004
VL - 87
IS - 2
M3 - Article
SP - 545
EP - 562
SN - 10603271
AB - Studies several methods that are combined for the analysis of conjugated linoleic acids and trans-18:1 isomers in dairy fats. Gas chromatography; Silver-ion thin-layer chromatography/gas chromatography; Silver-ion liquid chromatography.
KW - LINOLEIC acid
KW - ESSENTIAL fatty acids
KW - DAIRY products
KW - FAT
KW - GAS chromatography
KW - LIQUID chromatography
N1 - Accession Number: 13263701; Cruz-Hernandez, Cristina 1 Deng, Zeyuan 2 Jianqiang Zhou 1 Hill, Arthur R. 1 Yurawecz, Martin P. 3 Delmonte, Pierluigi 4 Mossoba, Magdi M. 1; Email Address: kramerj@agr.gc.ca Dugan, Michael E.R. Kramer, John K.G.; Affiliation: 1: Agriculture and Agri-Food Canada, Foor Research Program, Canada, University of Guelph, Department of Food Science, Canada 2: Agriculture and Agri-Food Canada, Food Research Program, Canada, University of Nanchang, Department of Food Science, China 3: U.S. Food and Drug Administration 4: Agriculture and Agri-Food Canada, Lacombe Research Center, Canada; Source Info: Mar/Apr2004, Vol. 87 Issue 2, p545; Subject Term: LINOLEIC acid; Subject Term: ESSENTIAL fatty acids; Subject Term: DAIRY products; Subject Term: FAT; Subject Term: GAS chromatography; Subject Term: LIQUID chromatography; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 18p; Illustrations: 1 Diagram, 3 Charts, 17 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delmonte, Pierluigi
AU - Yurawecz, Martin P.
AU - Mossoba, Magdi M.
AU - Cruz-Hernandez, Cristina
AU - Kramer, John K.G.
T1 - Improved Identification of Conjugated Linoleic Acid Isomers Using Silver-Ion HPLC Separations.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/03//Mar/Apr2004
VL - 87
IS - 2
M3 - Article
SP - 563
EP - 568
SN - 10603271
AB - Studies the use of silver-ion high performance liquid chromatography separations to improve the identification of conjugated linoleic acid (CLA) isomers. CLA isomers identified in natural fats from ruminants; Addition of diethyl ether to the mobile phase that partly stabilizes the solvent mixture; Synthesis of authentic CLA isomers.
KW - LINOLEIC acid
KW - ESSENTIAL fatty acids
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - FAT
KW - ETHER (Anesthetic)
N1 - Accession Number: 13263702; Delmonte, Pierluigi 1 Yurawecz, Martin P. 1; Email Address: mpy@cfsan.fda.gov Mossoba, Magdi M. 1 Cruz-Hernandez, Cristina 2 Kramer, John K.G. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition 2: Agriculture and Agri-Food Canada, Food Research Program, Canada; Source Info: Mar/Apr2004, Vol. 87 Issue 2, p563; Subject Term: LINOLEIC acid; Subject Term: ESSENTIAL fatty acids; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: FAT; Subject Term: ETHER (Anesthetic); NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Illustrations: 2 Diagrams, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Differential effects of sodium selenite in reducing tissue damage caused by three hemoglobin-based oxygen carriers.
AU - Baldwin, Ann L.
AU - Wiley, Elizabeth B.
AU - Alayash, Abdu I.
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
Y1 - 2004/03//
VL - 96
IS - 3
SP - 893
EP - 903
SN - 87507587
N1 - Accession Number: 12589546; Author: Baldwin, Ann L.: 1 email: abaldwin@u.arizona.edu. Author: Wiley, Elizabeth B.: 1 Author: Alayash, Abdu I.: 2 ; Author Affiliation: 1 Department of Physiology, College of Medicine, University of Arizona: 2 Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland; No. of Pages: 11; Language: English; Publication Type: Article; Update Code: 20040323
N2 - Examines whether sodium selenite would reduce the microvascular damage caused by PolyHbBv and O-R-PolyHbA[sub 0] in the rat mesentery and whether site-specific modifications of hemoglobin (Hb) can play a role in the interactions between Hb and selenium; Measurement of the effects of sodium selenite on the rates of autooxidation, oxidation and oxygen affinity of the Hbs.
KW - *HEMOGLOBIN
KW - *TISSUES
KW - SELENITES
KW - SODIUM selenite
KW - MESENTERY
KW - RATS as laboratory animals
KW - intestinal mucosal epithelium
KW - mast cell degranulation
KW - rat mesentery
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Wegienka, Ganesa
AU - Baird, Donna Day
AU - Hertz-Picciotto, Irva
AU - Harlow, Siobán D.
AU - Hartmann, Katherine E.
T1 - Uterine leiomyomata (fibroids): are bleeding symptoms more likely to be reported after diagnosis?
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2004/03//
VL - 57
IS - 3
M3 - Article
SP - 318
SN - 08954356
N1 - Accession Number: 12745647; Wegienka, Ganesa 1,2; Email Address: gwegien1@hfhs.org Baird, Donna Day 2 Hertz-Picciotto, Irva 3 Harlow, Siobán D. 4 Hartmann, Katherine E. 5; Affiliation: 1: Department of Biostatistics and Research Epidemiology, Henry Ford Health System, One Ford Place, 3E, Detroit, MI 48202, USA 2: Epidemiology Branch, The National Institute of Environmental Health Sciences, The National Institutes of Health, The United States Department of Health and Human Services, Mail Drop A3-05, P.O. Box 12233, Research Triangle Park, NC 27709, USA 3: Department of Epidemiology and Preventive Medicine, TB-168, University of California Davis, One Shields Avenue, Davis, CA 95616-8638, USA 4: Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, 1009 SPH 1, Ann Arbor, MI 48109-2029, USA 5: The North Carolina Program for Women's Health Research, University of North Carolina–Chapel Hill, 725 Airport Road, CB#7590, Chapel Hill, NC 27599-7590, USA; Source Info: Mar2004, Vol. 57 Issue 3, p318; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jclinepi.2003.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106665724
T1 - Meta-analysis: its role in the drug approval process and the implications for evidence-based dentistry.
AU - Anello C
AU - Hyman F
Y1 - 2004/03//2004 Mar
N1 - Accession Number: 106665724. Language: English. Entry Date: 20041119. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101083101.
KW - Dentistry
KW - Drug Approval
KW - Meta Analysis -- Utilization
KW - Professional Practice, Evidence-Based
SP - 52
EP - 58
JO - Journal of Evidence-Based Dental Practice
JF - Journal of Evidence-Based Dental Practice
JA - J EVID BASED DENT PRACT
VL - 4
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1532-3382
AD - Office of Biostatistics and Division of Dermatological and Dental Products Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Borucinska, J. D.
AU - Harshbarger, J. C.
AU - Reimschuessel, R.
AU - Bogicevic, T.
T1 - Short communication Gingival neoplasms in a captive sand tiger shark, Carcharias taurus (Rafinesque), and a wild-caught blue shark, Prionace glauca (L.).
JO - Journal of Fish Diseases
JF - Journal of Fish Diseases
Y1 - 2004/03//
VL - 27
IS - 3
M3 - Article
SP - 185
EP - 191
PB - Wiley-Blackwell
SN - 01407775
AB - Neoplasms of odontogenic origin with stromal and epithelial elements and tumors of oral epithelium are well known in domestic animals. The purpose of this article is to describe two oral tumours in sharks, a sand tiger shark Carcharias taurus and a blue shark Prionace glauca. The oral tumour from the first shark was submitted as a biopsy to the University of Maryland's Pathobiology Center in 1993 by a commercial aquarium. The tumour had been removed, under anaesthesia, from the gingiva posterior to the maxillary teeth.
KW - TUMORS in animals
KW - ODONTOGENIC tumors
KW - SHARKS
KW - GINGIVAL hyperplasia
KW - MANDIBLE
KW - CELLULAR pathology
N1 - Accession Number: 12453128; Borucinska, J. D. 1; Email Address: borucinsk@hartford.edu Harshbarger, J. C. 2 Reimschuessel, R. 3 Bogicevic, T. 1; Affiliation: 1: Department of Biology, University of Hartford, West Hartford, CT, USA. 2: Department of Pathology, George Washington University Medical Center, Washington, DC, USA. 3: Office of Research, United States Food and Drug Administration, Laurel, MD, USA.; Source Info: Mar2004, Vol. 27 Issue 3, p185; Subject Term: TUMORS in animals; Subject Term: ODONTOGENIC tumors; Subject Term: SHARKS; Subject Term: GINGIVAL hyperplasia; Subject Term: MANDIBLE; Subject Term: CELLULAR pathology; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1365-2761.2004.00532.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, Roderick C.
AU - Gerber, Susan I.
AU - Diaz, Pamela S.
AU - Williams, Larry L.
AU - Dennis, Sherri B.
AU - Parish, Eileen S.
AU - Paul, William S.
T1 - Intensive Investigation of Bacterial Foodborne Disease Outbreaks: Proposed Guidelines and Tools for the Collection of Dose-Response Data by Local Health Departments.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/03//
VL - 67
IS - 3
M3 - Article
SP - 616
EP - 623
SN - 0362028X
AB - Local health departments that investigate foodborne disease outbreaks do not have adequate guidelines for collecting data that could be used to estimate dose-response relationships, a key component of hazard characterization in quantitative microbial risk assessment. To meet this need, criteria and a questionnaire template for the collection of appropriate dose-response data in the context of outbreaks were developed and applied in the investigation of a point-source outbreak linked to Salmonella serotype Enteritidis in a salmon entree in February 2000. In this outbreak, the attack rate and risk of hospitalization increased with the amount of salmon entree consumed, and detailed data were obtained on illness severity measures and host susceptibility factors. Local health departments might consider broadening investigations to include the collection of additional data when investigating outbreaks that have met a specific set of conditions. These data could provide information needed by federal regulatory agencies and other organizations for quantitative microbial risk assessment. Intensive investigations of outbreaks could prevent future illnesses by providing information needed to develop approaches to minimizing risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Health risk assessment
KW - Epidemics
KW - Enteritis
KW - United States
N1 - Accession Number: 12732665; Jones, Roderick C. 1; Email Address: Jones_Rodericl@cdph.org; Gerber, Susan I. 1; Diaz, Pamela S. 1; Williams, Larry L. 2; Dennis, Sherri B. 3; Parish, Eileen S. 3; Paul, William S. 1; Affiliations: 1: Chicago Department of Public Health, Chicago, Illinois; 2: Illinois Department of Public Health, Chicago, Illinois; 3: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Maryland, USA; Issue Info: Mar2004, Vol. 67 Issue 3, p616; Thesaurus Term: Foodborne diseases; Thesaurus Term: Health risk assessment; Thesaurus Term: Epidemics; Subject Term: Enteritis; Subject: United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Elkins, Christopher A.
AU - Savage, Dwayne C.
T1 - CbsT2 from Lactobacillus johnsonii 100-100 Is a Transport Protein of the Major Facilitator Superfamily That Facilitates Bile Acid Antiport.
JO - Journal of Molecular Microbiology & Biotechnology
JF - Journal of Molecular Microbiology & Biotechnology
Y1 - 2004/03//
VL - 6
IS - 2
M3 - Article
SP - 76
EP - 87
SN - 14641801
AB - We previously identified two conjugated bile acid transporters, CbsT1 and CbsT2, in Lactobacillus johnsonii 100-100 and Lactobacillus acidophilus KS-13 that are gene duplicates encoded in tandem with a conjugated bile salt hydrolase (BSH) [Elkins and Savage, J. Bacteriol. 180:4344–4349, 1998; Elkins et al., Microbiology 147: 3403–3412, 2001]. CbsT2 from 100–100 was shown to increase taurocholic acid (TCA) uptake in Escherichia coli; however, higher levels were achieved when an extracellular factor (EF) from 100–100 was present in the assay medium (spent medium from 100–100, pH 4.2). We continued this study here to determine the role of EF in this transport system. Kinetic studies revealed that the previously observed CbsT2- and EF-mediated TCA accumulation is rapid (<15 s) but not saturable, suggesting that EF is limiting. In addition, uptake of TCA by E. coli expressing CbsT2 was insensitive to ionophores, 2,4-dinitrophenol and carbonyl cyanide m-chlorophenylhydrazone, and thus, is independent of the proton motive force. Since BSH converts [24-[sup 14] C]TCA to [24-[sup 14] C]cholic acid (CA), we measured net radiolabel uptake in E. coli cells expressing transporter(s) and BSH. Interestingly, such cells accumulated less [sup 14] C radiolabel (by approximately half) than cells expressing CbsT2 alone. These data can be explained if CA diffuses out of E. coli through the transporter(s). We, therefore, added exogenous, unlabeled CA to EF-spent media, which under our assay conditions, performed similarly to EF+ culture supernatant in TCA and CA uptake assays. Thus, unlabeled CA (a protonated, neutral lipophile) can partition directly into E. coli cells especially at low pH. These findings were validated in uptake assays with [[sup 3] H]TCA, which yields [[sup 3] H]taurine (a hydrophilic moiety) upon hydrolysis by the BSH. Amounts of cell-associated [sup 3] H radiolabel remained similar in cells expressing CbsT2 and BSH versus cells expressing only CbsT2, both of which were higher than in cells expressing BSH alone. Our data support a hypothesis that these transporters, which comprise a new subfamily of the major facilitator superfamily, facilitate antiport of TCA and CA. Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Molecular Microbiology & Biotechnology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LACTOBACILLUS
KW - PROTEINS
KW - BILE acids
KW - BILE salts
KW - ESCHERICHIA coli
KW - CARRIER proteins
KW - HYDROLYSIS
KW - Antiport
KW - Bile acids
KW - Bile salt hydrolysis
KW - Major facilitator superfamily
N1 - Accession Number: 12616685; Elkins, Christopher A. 1,2; Email Address: Caelkins@nctr.fda.gov Savage, Dwayne C. 1; Affiliation: 1: Department of Microbiology, University of Tennessee, Knoxville, Tennessee 2: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Ark., USA; Source Info: 2004, Vol. 6 Issue 2, p76; Subject Term: LACTOBACILLUS; Subject Term: PROTEINS; Subject Term: BILE acids; Subject Term: BILE salts; Subject Term: ESCHERICHIA coli; Subject Term: CARRIER proteins; Subject Term: HYDROLYSIS; Author-Supplied Keyword: Antiport; Author-Supplied Keyword: Bile acids; Author-Supplied Keyword: Bile salt hydrolysis; Author-Supplied Keyword: Major facilitator superfamily; Number of Pages: 12p; Document Type: Article
L3 - 10.1159/000076738
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Golla, Vijay
AU - Heitbrink, William
T1 - Control Technology for Crystalline Silica Exposures in Construction: Wet Abrasive Blasting.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/03//
VL - 1
IS - 3
M3 - Article
SP - D26
EP - D32
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study was designed to document the effect that wet abrasive blasting has on reducing worker exposure to crystalline silica, which has been associated with silicosis and premature death. In this study, worker exposure to respirable crystalline silica was monitored during we! abrasive blasting on the exterior walls of a parking garage to remove surface concrete and expose the underlying aggregate. In this process a we! sand mix comprised of 80% dry sand and 20% water was used. Sampling and analysis revealed that the geometric mean respirable quartz concentration was 0.2 mg/m3 for workers conducting abrasive blasting and 0.06 mg/m3 for helpers. When abrasive blasting was conducted in area that apparently had reduced natural ventilation, dust exposures appeared to increase. when compared with other published data, this case study suggests that wet abrasive blasting causes less exposure to crystalline silica than dry abrasive blasting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Industrial hygiene
KW - Occupational hazards
KW - Blasting
KW - Abrasives
KW - Silica
KW - Quartz crystals
KW - Silicosis
N1 - Accession Number: 12827348; Golla, Vijay 1; Heitbrink, William 1; Affiliations: 1: Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Issue Info: Mar2004, Vol. 1 Issue 3, pD26; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Industrial hygiene; Thesaurus Term: Occupational hazards; Subject Term: Blasting; Subject Term: Abrasives; Subject Term: Silica; Subject Term: Quartz crystals; Subject Term: Silicosis; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 327910 Abrasive Product Manufacturing; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 325920 Explosives Manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 213115 Support Activities for Nonmetallic Minerals (except Fuels) Mining; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15459620490279665
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cavanaugh, Doreen A.
AU - Muck, Randolph D.
T1 - Using Research to Improve Treatment for Adolescents: Findings from Two CSAT Demonstrations.
JO - Journal of Psychoactive Drugs
JF - Journal of Psychoactive Drugs
Y1 - 2004/03//
VL - 36
IS - 1
M3 - Article
SP - 1
EP - 3
SN - 02791072
AB - Introduces articles regarding the use of research to improve the treatment for addicted adolescents, published in the March 2004 issue of the "Journal of Psychoactive Drugs."
KW - TEENAGERS -- Substance use
KW - SUBSTANCE abuse
KW - ADDICTIONS
KW - DRUG abuse
KW - RESEARCH
KW - PERIODICALS
N1 - Accession Number: 13001483; Cavanaugh, Doreen A. 1 Muck, Randolph D. 2; Affiliation: 1: Health Policy Institute, Georgetown Public Policy Institute, Georgetown University, Washington, D.C. 2: Center for Substance Abuse Treatment, Subtance Abuse and Mental Health Services Administration, Rockville, Maryland; Source Info: Mar2004, Vol. 36 Issue 1, p1; Subject Term: TEENAGERS -- Substance use; Subject Term: SUBSTANCE abuse; Subject Term: ADDICTIONS; Subject Term: DRUG abuse; Subject Term: RESEARCH; Subject Term: PERIODICALS; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvartsburg, Alexandre A.
AU - Jones, Richard C.
T1 - Attachment of metal trications to peptides
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2004/03//
VL - 15
IS - 3
M3 - Article
SP - 406
SN - 10440305
AB - Gas-phase complexes of triply charged metal ions with peptides may be readily produced using electrospray ionization, including for small peptides such as bradykinin and peptides with no basic residues such as insulin chain A. Attachment without charge-reduction is demonstrated for all trications studied: La3+, Al3+, Ga3+, Fe3+, V3+, and Cr3+. The intensities of adducts are often comparable to, or even exceed, those of protonated analogs in any charge state. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METAL ions
KW - PEPTIDES
KW - BRADYKININ
KW - INSULIN
N1 - Accession Number: 12379816; Shvartsburg, Alexandre A. 1; Email Address: alexandre.shvartsburg@pnl.gov Jones, Richard C. 2; Affiliation: 1: Pacific Northwest National Laboratory, Richland, Washington, USA 2: Chemistry Division, National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Mar2004, Vol. 15 Issue 3, p406; Subject Term: METAL ions; Subject Term: PEPTIDES; Subject Term: BRADYKININ; Subject Term: INSULIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jasms.2003.11.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de Rosny, Eve
AU - Vassell, Russell
AU - Shibo Jiang
AU - Kunert, Renate
AU - Weiss, Carol D.
T1 - Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/03//
VL - 78
IS - 5
M3 - Article
SP - 2627
EP - 2631
SN - 0022538X
AB - We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus entry. We also demonstrate conformational changes in the C heptad of gp41. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - HIV (Viruses)
KW - GLYCOPROTEINS
KW - VIRUSES
KW - IMMUNOGLOBULINS
KW - VIROLOGY
N1 - Accession Number: 12517941; de Rosny, Eve 1 Vassell, Russell 1 Shibo Jiang 2 Kunert, Renate 3 Weiss, Carol D. 1; Email Address: cdweiss@helix.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration 2: Lindsley F. Kimball Research Institute, New York Blood Center 3: Institute of Applied Microbiology, Universität für Bodenkultur; Source Info: Mar2004, Vol. 78 Issue 5, p2627; Subject Term: MONOCLONAL antibodies; Subject Term: HIV (Viruses); Subject Term: GLYCOPROTEINS; Subject Term: VIRUSES; Subject Term: IMMUNOGLOBULINS; Subject Term: VIROLOGY; Number of Pages: 5p; Illustrations: 3 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.5.2627-2631.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Ying
AU - Howard, Barbara V.
AU - Cowan, Linda D.
AU - Welty, Thomas K.
AU - Schaefer, Carl F.
AU - Wild, Robert A.
AU - Yeh, Jeunliang
AU - Lee, Elisa T.
T1 - Associations of Postmenopausal Hormone Therapy with Markers of Hemostasis and Inflammation and Lipid Profiles in Diabetic and Nondiabetic American Indian Women: The Strong Heart Study.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2004/03//
VL - 13
IS - 2
M3 - Article
SP - 155
EP - 163
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - To examine the associations of postmenopausal hormone therapy (PHT) with indicators of hemostasis and inflammation and with lipid profiles in American Indian women and to determine if diabetes modifies these associations. This report is a cross-sectional analysis of data from 1446 postmenopausal women who were free from cardiovascular disease (CVD) at the second Strong Heart Study examination (1993–1995). Diabetes was diagnosed by WHO criteria. Postmenopausal hormone use was ascertained by review of the medications brought to the examination or by medical record review. Lipoproteins, plasminogen activator inhibitor type 1 (PAI-1), fibrinogen, and C-reactive protein (CRP) were measured in fasting plasma samples. Among nondiabetic women, current PHT users had lower mean fibrinogen, PAI-1, and low-density lipoprotein cholesterol (LDLC) levels than those in never users (38.4 mg/dl, 8.68 ng/ml, and 14.16 mg/dl lower, respectively) but higher CRP and triglyceride levels (1.53 mg/l and 31.43 mg/dl higher, respectively). Multivariate adjustment did not alter any of these associations. In diabetic women, current PHT use was associated only with lower PAI-1 (5.48 ng/ml lower) and higher high-density lipoprotein cholesterol (HDLC) levels (3.33 mg/dl higher) compared with never users. In American Indian women without diabetes, PHT was associated with lower levels of hemostatic markers but higher levels of an inflammatory marker. Associations were less marked in women with diabetes. The relation of PHT with lipid profiles also differed in nondiabetic and diabetic women. These data provide an additional rationale for considering diabetes status when deciding whether or not to use PHT. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HORMONE therapy
KW - DIABETES -- Diagnosis
KW - CARDIOVASCULAR diseases
KW - WOMEN -- Health
KW - WOMEN -- Diseases
KW - PUBLIC health
KW - EPIDEMIOLOGY
N1 - Accession Number: 12761804; Zhang, Ying 1; Email Address: ying-zhang4@ouhsc.edu Howard, Barbara V. 2 Cowan, Linda D. 3 Welty, Thomas K. 4 Schaefer, Carl F. 1 Wild, Robert A. 5 Yeh, Jeunliang 1 Lee, Elisa T. 1; Affiliation: 1: Center for American Indian Health Research, University of Oklahoma HSC, Oklahoma City, Oklahoma 2: MedStar Research Institute, Washington, D.C. 3: Department of Biostatics and Epidemiology, University of Oklahoma HSC, Oklahoma City, Oklahoma 4: Public Health Service, Indian Hospital, Rapid City, South Dakota 5: Department of Obstetrics/Gynecology, University of Oklahoma HSC, Oklahoma City, Oklahoma; Source Info: Mar2004, Vol. 13 Issue 2, p155; Subject Term: HORMONE therapy; Subject Term: DIABETES -- Diagnosis; Subject Term: CARDIOVASCULAR diseases; Subject Term: WOMEN -- Health; Subject Term: WOMEN -- Diseases; Subject Term: PUBLIC health; Subject Term: EPIDEMIOLOGY; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, J.Z.
AU - Dong, R.G.
AU - Rakheja, S.
AU - Schopper, A.W.
AU - Smutz, W.P.
T1 - A structural fingertip model for simulating of the biomechanics of tactile sensation
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
Y1 - 2004/03//
VL - 26
IS - 2
M3 - Article
SP - 165
SN - 13504533
AB - Tactile performance of human fingertips is associated with activity of the nerve endings and sensitivity of the soft tissue within the fingertip to the static and dynamic skin indentation. The nerve endings in the fingertips sense the stress/strain states developed within the soft tissue, which are affected by the material properties of the tissues. The vibrotactile sensation and tactile performance are thus believed to be strongly influenced by the nonlinear and time-dependent properties of the soft tissues. The purpose of the present research is to simulate the biomechanics of tactile sensation. A two-dimensional model, which incorporates the essential anatomical structures of a finger (i.e. skin, subcutaneous tissue, bone, and nail), has been used for the analysis. The skin tissue is assumed to be hyperelastic and viscoelastic. The subcutaneous tissue is considered to be a nonlinear, biphasic material composed of a hyperelastic solid and an inviscid fluid phase. The nail and bone are considered to be linearly elastic. The advantages of the proposed fingertip model over the previous “waterbed” and “continuum” fingertip models include its ability to predict the deflection profile of the fingertip surface, the stress and strain distributions within the soft tissue, and most importantly, the dynamic response of the fingertip to mechanical stimuli. The proposed model is applied to simulate the mechanical responses of a fingertip under a line load, and in one-point (1PT) and two-point (2PT) tactile discrimination tests. The model’s predictions of the deflection profiles of a fingertip surface under a line load agree well with the reported experimental data. Assuming that the mechanoreceptors in the dermis sense the stimuli associated with normal strains (the vertical and horizontal strains) and strain energy density, our numerical results suggest that the threshold of 2PT discrimination may lie between 2.0 and 3.0 mm, which is consistent with the published experimental data. The present study represents an effort to develop a structural model of the fingertip that incorporates its anatomical structure, and the nonlinear and time-dependent properties of the soft tissues. [Copyright &y& Elsevier]
AB - Copyright of Medical Engineering & Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TACTILE sensors
KW - SOFT tissue injuries
KW - SKIN
KW - NERVE endings
KW - Finite element model
KW - Hyperelastic
KW - Poroelastic
KW - Soft tissue mechanics
KW - Tactile sensation
N1 - Accession Number: 11730600; Wu, J.Z. 1; Email Address: jwu@cdc.gov Dong, R.G. 1 Rakheja, S. 1 Schopper, A.W. 1 Smutz, W.P. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Concordia University, Montreal, Quebec H3G 1M8, Canada; Source Info: Mar2004, Vol. 26 Issue 2, p165; Subject Term: TACTILE sensors; Subject Term: SOFT tissue injuries; Subject Term: SKIN; Subject Term: NERVE endings; Author-Supplied Keyword: Finite element model; Author-Supplied Keyword: Hyperelastic; Author-Supplied Keyword: Poroelastic; Author-Supplied Keyword: Soft tissue mechanics; Author-Supplied Keyword: Tactile sensation; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.medengphy.2003.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slater, Jay E.
T1 - Recombinant allergens in the US
JO - Methods
JF - Methods
Y1 - 2004/03//
VL - 32
IS - 3
M3 - Article
SP - 209
SN - 10462023
AB - Recombinant allergens may increase the safety and efficacy of allergen immunodiagnostics and immunotherapy, and may prove to be excellent tools for the standardization of existing, natural allergens. However, there are several biological and regulatory issues that need to be addressed as these products are moved from bench to bedside. This article discusses some of these issues. [Copyright &y& Elsevier]
AB - Copyright of Methods is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - IMMUNODIAGNOSIS
KW - IMMUNOTHERAPY
KW - UNITED States
N1 - Accession Number: 12173427; Slater, Jay E. 1; Affiliation: 1: Laboratory of Immunobiochemistry, Division of Bacterial Parasitic and Allergenic Products, Office of Vaccines Regulation and Research, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA; Source Info: Mar2004, Vol. 32 Issue 3, p209; Subject Term: ALLERGENS; Subject Term: IMMUNODIAGNOSIS; Subject Term: IMMUNOTHERAPY; Subject Term: UNITED States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.ymeth.2003.08.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cisneros, Francisco J.
AU - Branch, Stacy
T1 - Transplacental Exposure to the DNA Demethylating Agent, 5-AZA-CdR, Affects the Sexual Behavior of CD-1 Male Mice
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2004/03//
VL - 25
IS - 3
M3 - Article
SP - 411
SN - 0161813X
AB - Intrauterine exposure to 5-AZA-2′-deoxycytidine (5-AZA-CdR) alters gene expression causing malformations, abnormal post-natal growth and altered reproductive capacity. To elucidate whether the phenomenon observed in 5-AZA-CdR in utero exposed male mice was a behavioral alteration, at gestation day (GD) 10, CD-1 pregnant mice were administered 1 mg/kg i.p. of 5-AZA-CdR or saline solution. After parturition, the number and sex of pups were recorded. While litter size was not affected, the ratio of male to female offspring was altered in treated mice. To determine whether the phenotypic observation of male gender corresponded to the appropriate genotype, presence of Sry gene in 5-AZA-CdR F1 males was determined. At 3 months of age, the male sexual behavior test outlined by Chubb was conducted. Presence of vaginal plug and pregnancy were determined in the natural breeding phase. Mount latency and number of mounts per mouse were assessed in the behavioral test phase. In utero exposed male mice resulted in diminished mating behavior (as measured by vaginal plug presence, mount latency and number of mounts) and reduced sexual interest while exposed to a receptive female. While normal presence of Sry gene was observed, mating behavior was altered in exposed males suggesting that the reproductive alteration could be attributed to a behavioral phenomenon. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - MICE
KW - PREGNANCY in animals
KW - SEXUAL behavior in animals
KW - ANIMAL behavior
KW - 5-AZA-2′-deoxycytidine (5-AZA-CdR)
KW - Daily sperm production
KW - Reproductive behavior
KW - Reproductive toxicity
KW - Sry gene
N1 - Accession Number: 12374717; Cisneros, Francisco J. 1; Email Address: fcisneros@nctr.fda.gov Branch, Stacy 2; Affiliation: 1: National Center for Toxicological Research /FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA 2: Department of Environmental & Molecular Toxicology, North Carolina State University, 850 Main Campus Dr. Room 1105, Raleigh, NC 27695, USA; Source Info: Mar2004, Vol. 25 Issue 3, p411; Subject Term: GENE expression; Subject Term: MICE; Subject Term: PREGNANCY in animals; Subject Term: SEXUAL behavior in animals; Subject Term: ANIMAL behavior; Author-Supplied Keyword: 5-AZA-2′-deoxycytidine (5-AZA-CdR); Author-Supplied Keyword: Daily sperm production; Author-Supplied Keyword: Reproductive behavior; Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Sry gene; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuro.2003.09.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pinkerton, L. E.
AU - Hein, M. J.
AU - Stayner, L. T.
T1 - Mortality among a cohort of garment workers exposed to formaldehyde: an update.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2004/03//
VL - 61
IS - 3
M3 - Article
SP - 193
EP - 200
SN - 13510711
AB - Aims: To evaluate the mortality experience of 11 039 workers exposed to formaldehyde for three months or more in three garment plants. The mean time weighted average formaldehyde exposure at the plants in the early 1980s was 0.15 ppm but past exposures may have been substantially higher. Methods: Vital status was updated through 1998, and life table analyses were conducted. Results: Mortality from all causes (2206 deaths, standardised mortality ratio (SMR) 0.92, 95% CI 0.88 to 0.96) and all cancers (SMR 0.89, 95% CI 0.82 to 0.97) was less than expected based on US mortality rates. A non-significant increase in mortality from myeloid leukaemia (15 deaths, SMR 1.44, 95% CI 0.80 to 2.37) was observed. Mortality from myeloid leukaemia was greatest among workers first exposed in the earliest years when exposures were presumably higher, among workers with 10 or more years of exposure, and among workers with 20 or more years since first exposure. No nasal or nasopharyngeal cancers were observed. Mortality from trachea, bronchus, and lung cancer (147 deaths, SMR 0.98, 95% CI 0.82 to 1.15) was not increased. Multiple cause mortality from leukaemia was increased almost twofold among workers with both 10 or more years of exposure and 20 years or more since first exposure (15 deaths, SMR 1.92, 95% CI 1.08 to 3.17). Multiple cause mortality from myeloid leukaemia among this group of workers was also significantly increased (8 deaths, SMR 2.55, 95% CI 1.10 to 5.03). Conclusions: Results support a possible relation between formaldehyde exposure and myeloid leukaemia mortality. Previous epidemiological studies supporting a relation between formaldehyde exposure and leukaemia mortality have been primarily of formaldehyde exposed professional groups, not formaldehyde exposed industrial workers. Limitations include limited power to detect an excess for rare cancers such as nasal and nasopharyngeal cancers and lack of individual exposure estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Formaldehyde
KW - Hazardous substance exposure
KW - Hazardous substances
KW - Health risk assessment
KW - Industrial safety
KW - Occupational mortality
KW - Myeloid leukemia
KW - Diseases -- Risk factors
KW - Industrial workers
N1 - Accession Number: 12952004; Pinkerton, L. E. 1; Email Address: LPinkerton@cdc.gov; Hein, M. J. 1; Stayner, L. T. 2; Affiliations: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, The National Institute for Occupational Safely and Health, Cincinnati, Ohio, USA; 2: Risk Evaluation Branch, Education and Information Division, The National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Mar2004, Vol. 61 Issue 3, p193; Thesaurus Term: Formaldehyde; Thesaurus Term: Hazardous substance exposure; Thesaurus Term: Hazardous substances; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial safety; Subject Term: Occupational mortality; Subject Term: Myeloid leukemia; Subject Term: Diseases -- Risk factors; Subject Term: Industrial workers; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1136/oem.2003.007476
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12952004&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106572703
T1 - Mortality among a cohort of garment workers exposed to formaldehyde: an update.
AU - Pinkerton LE
AU - Hein MJ
AU - Stayner LT
Y1 - 2004/03//
N1 - Accession Number: 106572703. Language: English. Entry Date: 20050121. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Carcinogens -- Adverse Effects
KW - Clothing
KW - Formaldehyde -- Adverse Effects
KW - Neoplasms -- Mortality
KW - Occupational Diseases -- Mortality
KW - Occupational Exposure -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Aged
KW - Confidence Intervals
KW - Data Analysis Software
KW - Epidemiological Research
KW - Female
KW - Georgia
KW - Leukemia, Myeloid -- Chemically Induced
KW - Leukemia, Myeloid -- Mortality
KW - Male
KW - Middle Age
KW - National Institute for Occupational Safety and Health
KW - Pennsylvania
KW - Prospective Studies
KW - Sensitivity and Specificity
KW - Textile Industry
KW - United States Occupational Safety and Health Administration -- Standards
KW - Whites
KW - Work Environment
KW - Human
SP - 193
EP - 200
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 61
IS - 3
PB - BMJ Publishing Group
AB - AIMS: To evaluate the mortality experience of 11 039 workers exposed to formaldehyde for three months or more in three garment plants. The mean time weighted average formaldehyde exposure at the plants in the early 1980s was 0.15 ppm but past exposures may have been substantially higher. METHODS: Vital status was updated through 1998, and life table analyses were conducted. RESULTS: Mortality from all causes (2206 deaths, standardised mortality ratio (SMR) 0.92, 95% CI 0.88 to 0.96) and all cancers (SMR 0.89, 95% CI 0.82 to 0.97) was less than expected based on US mortality rates. A non-significant increase in mortality from myeloid leukaemia (15 deaths, SMR 1.44, 95% CI 0.80 to 2.37) was observed. Mortality from myeloid leukaemia was greatest among workers first exposed in the earliest years when exposures were presumably higher, among workers with 10 or more years of exposure, and among workers with 20 or more years since first exposure. No nasal or nasopharyngeal cancers were observed. Mortality from trachea, bronchus, and lung cancer (147 deaths, SMR 0.98, 95% CI 0.82 to 1.15) was not increased. Multiple cause mortality from leukaemia was increased almost twofold among workers with both 10 or more years of exposure and 20 years or more since first exposure (15 deaths, SMR 1.92, 95% CI 1.08 to 3.17). Multiple cause mortality from myeloid leukaemia among this group of workers was also significantly increased (8 deaths, SMR 2.55, 95% CI 1.10 to 5.03). CONCLUSIONS: Results support a possible relation between formaldehyde exposure and myeloid leukaemia mortality. Previous epidemiological studies supporting a relation between formaldehyde exposure and leukaemia mortality have been primarily of formaldehyde exposed professional groups, not formaldehyde exposed industrial workers. Limitations include limited power to detect an excess for rare cancers such as nasal and nasopharyngeal cancers and lack of individual exposure estimates.
SN - 1351-0711
AD - Epidemiology Section, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226; LPinkerton@cdc.gov
U2 - PMID: 14985513.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nicholson, Joanne
AU - Claylield, Jonathan C.
T1 - Responding to Depression in Parents.
JO - Pediatric Nursing
JF - Pediatric Nursing
Y1 - 2004/03//Mar/Apr2004
VL - 30
IS - 2
M3 - Article
SP - 136
EP - 142
PB - Jannetti Publications, Inc.
SN - 00979805
AB - According to the U.S. Surgeon General's Report on Mental Health, major depression is the predominant of four disorders commonly grouped together as affective or mood disorders: major depressive disorder, bipolar disorder, dysthymia, and cyclothymia. Major depression affects a person's body, mood, and thoughts. Dysthymia is a longer-lasting, less disabling, chronic Form of major depression, absent the thoughts of death and suicide. Likewise, cyctothymia involves less disabling, chronic mood swings from elation to depression, not meeting the full criteria for a manic, mixed, or major depressive episode. Depression may range from mild to severe. People dealing with the same level of depression will cope with their symptoms differently, depending on a multitude of factors such as early detection, response to treatment, effective coping strategies, and the availability of social supports.
KW - MENTAL depression
KW - DEPRESSED persons
KW - MENTAL health
KW - SYMPTOMS
KW - SOCIAL groups
KW - AFFECTIVE disorders
N1 - Accession Number: 13081818; Nicholson, Joanne 1 Claylield, Jonathan C. 2; Affiliation: 1: Associate Professor of Psychiatry and Family Medicine, Department of Psychiatry. Center for Mental Health Services Research. University of Massachusetts Medical School. Worcester, MA. 2: Research Associate. Department of Psychiatry. Center For Mental Health Services Research. University of Massachusetts Medical School, Worcester. MA.; Source Info: Mar/Apr2004, Vol. 30 Issue 2, p136; Subject Term: MENTAL depression; Subject Term: DEPRESSED persons; Subject Term: MENTAL health; Subject Term: SYMPTOMS; Subject Term: SOCIAL groups; Subject Term: AFFECTIVE disorders; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106750592
T1 - Family matters. Responding to depression in parents.
AU - Nicholson J
AU - Clayfield JC
A2 - Ahmann E
Y1 - 2004/03//Mar/Apr2004
N1 - Accession Number: 106750592. Language: English. Entry Date: 20050712. Revision Date: 20150818. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7505804.
KW - Depression -- Psychosocial Factors -- In Infancy and Childhood
KW - Parents -- Psychosocial Factors
KW - Child
KW - Depression -- Classification
KW - Depression -- Nursing
KW - Depression -- Prevention and Control
KW - Depression -- Symptoms
KW - Depression -- Therapy
KW - Health Screening -- Nursing
KW - Information Resources
KW - Mothers -- Psychosocial Factors
KW - Parents -- Education
KW - Pediatric Nursing
KW - World Wide Web
SP - 136
EP - 142
JO - Pediatric Nursing
JF - Pediatric Nursing
JA - PEDIATR NURS
VL - 30
IS - 2
CY - Pitman, New Jersey
PB - Jannetti Publications, Inc.
AB - Pediatric professionals may naturally view themselves as gatekeepers or facilitators of access to mental health services for children, but may not see themselves as the first line of 'defense' for parents with mental health issues. However, about two thirds of women who meet criteria for affective disorders, and slightly more than half of the men who do, are parents. Given that the average age of onset for affective disorders is several years after the birth of first children, parental depression may initially come to the attention of pediatric providers, the most likely professionals with whom parents have contact prior to children starting school. The health and well-being of parents and children are intimately intertwined. Simple screening, education, and support strategies for parents and referral to specialty services, when appropriate, have the potential for positive impact on all family members.
SN - 0097-9805
AD - Associate Professor of Psychiatry and Family Medicine, Dept of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA
U2 - PMID: 15185736.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106655597
T1 - Combining evidence-based practice with stakeholder consensus to enhance psychosocial rehabilitation services in the Texas Benefit Design Initiative.
AU - Cook JA
AU - Toprac M
AU - Shore SE
Y1 - 2004///Spring2004
N1 - Accession Number: 106655597. Language: English. Entry Date: 20050712. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: National Institute on Disability and Rehabilitation Research, U.S. Department of Education, and the Center for Mental Health Services, Substance Abuse and Mental Health Services Administration (Cooperative Agreement No. H133B000700). NLM UID: 9601800.
KW - Medical Practice, Evidence-Based
KW - Mental Health Services -- Administration
KW - Mental Health Services -- Methods
KW - Rehabilitation, Psychosocial -- Methods
KW - Funding Source
KW - Strategic Planning
KW - Texas
SP - 307
EP - 318
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 27
IS - 4
CY - Washington, District of Columbia
PB - American Psychological Association
AB - This article describes the use of evidence-based practice along with a multi-stakeholder consensus process to design the psychosocial rehabilitation components in a benefit package of publicly funded mental health services in Texas. The Texas Benefit Design initiative demonstrates how the combination of science and consensus can be used as a powerful tool for change. It applies the findings of rigorous research regarding psychosocial rehabilitation service delivery approaches that achieve positive outcomes in real world, community settings. At the same time, it makes use of the unique knowledge and experience that mental health service consumers, providers and other advocates can bring to service system design and planning.
SN - 1095-158X
AD - Professor/Director of the Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago; cook@ripco.com
U2 - PMID: 15222144.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106655597&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106606121
T1 - Datapoints. Trends in naltrexone use among members of a large private health plan.
AU - Harris KM
AU - DeVries A
AU - Dimidjian K
Y1 - 2004/03//
N1 - Accession Number: 106606121. Language: English. Entry Date: 20050415. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Drug Therapy -- Trends
KW - Insurance, Health
KW - Naltrexone -- Therapeutic Use
KW - Alcoholism -- Drug Therapy
KW - Descriptive Statistics
KW - United States
KW - Human
SP - 221
EP - 221
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 55
IS - 3
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Office of Applied Studies of the Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, room 16-105, Rockville, MD 20857; kharris@samhsa.gov
U2 - PMID: 15001719.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106606121&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - McCammon, Jane B.
AU - Jumbelic, Mary I.
AU - Baron, Robert L.
T1 - COMMENTS ON WATERCRAFT-RELATED DROWNINGS.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2004/03//Mar/Apr2004
VL - 119
IS - 2
M3 - Letter
SP - 112
EP - 113
SN - 00333549
AB - Presents a letter to the editor about boat-related carbon monoxide poisonings in the U.S.
KW - LETTERS to the editor
KW - DROWNING
N1 - Accession Number: 18449883; McCammon, Jane B. 1 Jumbelic, Mary I. Baron, Robert L. 2,3; Affiliation: 1: National Institute for Occupational Safety and Health Denver Field Office Director, Denver, Colorado 80225 2: ED Co-Director, Banner Good Samaritan Regional Medical Center, Phoenix 3: Medical Director, Glen Canyon National Recreation Area; Source Info: Mar/Apr2004, Vol. 119 Issue 2, p112; Subject Term: LETTERS to the editor; Subject Term: DROWNING; Number of Pages: 2p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18449883&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106622326
T1 - Comments on watercraft-related drownings...Watercraft-related drownings among New York State residents, 1988-1994. Public Health Rep 2003;118:459-63
AU - McCammon JB
AU - Jumbelic MI
AU - Baron RL
AU - Browne ML
Y1 - 2004/03//Mar/Apr2004
N1 - Accession Number: 106622326. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter; response. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Aquatic Sports
KW - Carbon Monoxide Poisoning -- Epidemiology -- United States
KW - Drowning -- Epidemiology -- United States
KW - Drowning -- Risk Factors
KW - Alcohol Abuse -- Complications
KW - Information Resources
KW - New York
KW - United States
SP - 112
EP - 113
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 119
IS - 2
PB - Sage Publications Inc.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health Denver Field Office Director, Denver, Colorado 80225
U2 - PMID: 15192896.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106622326&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Accurate body composition equations for American Indian men. (Abstract)
AU - Hicks, V.
AU - Reano, L.
JO - Research Quarterly for Exercise & Sport
JF - Research Quarterly for Exercise & Sport
Y1 - 2004/03//
VL - 75
IS - 1 Suppl
SP - A
EP - 9-a-10
CY - ;
SN - 02701367
N1 - Accession Number: SPHS-949578; Author: Hicks, V.: 1 email: hicksv@uww.edu. Author: Reano, L.: 2 email: lorene.reano@mail.ihs.gov. ; Author Affiliation: 1 University of Wisconsin-Whitewater: 2 Indian Health Service; Conference: American Alliance for Health, Physical Education, Recreation and Dance (2004 : New Orleans, Louisiana).; No. of Pages: 2; Language: English; Parent Item: SPHP2055; General Notes: Exercise physiology and fitness.; Publication Type: Article; Material Type: PRINT; Update Code: 20061001; SIRC Article No.: S-949578
KW - *BODY composition
KW - MATHEMATICAL models
KW - MALES
KW - INDIANS of North America
KW - CALIBRATION
KW - ACCURACY
L2 - http://articles.sirc.ca/search.cfm?id=S-949578
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=SPHS-949578&site=ehost-live&scope=site
UR - http://articles.sirc.ca/search.cfm?id=S-949578
UR - http://www.aahperd.org/
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Kang, Hye Na
AU - Kim, Soon Nam
AU - Lee, Seok Ho
AU - Hong, Seung Hwa
T1 - A collaborative study to establish a Korean Standard for factor VIII:C concentrate
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2004/03//
VL - 113
IS - 3/4
M3 - Article
SP - 261
EP - 267
SN - 00493848
AB - Background and objectives: A collaborative study among five laboratories including three manufacturers and two national control laboratories was carried out to evaluate the suitability of a candidate to serve as a Korean Standard for factor VIII:C concentrate. Materials and methods: Two approaches were attempted to determine the potency of this candidate. The one is a one-stage clotting assay and the other is a chromogenic assay. To achieve acceptable precision and accuracy, the following recommendations by the International Society on Thrombosis and Haemostasis were adopted in the assays, e.g., pre-dilution of samples in factor VIII (FVIII)-deficient plasma, inclusion of 1% albumin in the dilution buffer and calibration against the sixth International Standard for the blood coagulation factor VIII:C concentrate, coded 97/616. Results: The data collected within each laboratory and among laboratories for both assays employed here were in good agreements in the calibration of the candidate preparation against the International Standard. The overall potencies by the one-stage clotting assay and the chromogenic assay, however, showed recognizable differences between them. Each differed from each other in that the potency obtained from chromogenic assay was approximately 17% lower than that from one-stage clotting assay. The estimated geometric mean value obtained from the one-stage clotting assay was 8.4 international units (IU)/vial and that from the chromogenic assay was 6.7 IU/vial. Conclusions: Based on the results of this collaborative study, the candidate standard is judged to be suitable to serve as a Korean National Standard for factor VIII:C concentrate. [Copyright &y& Elsevier]
AB - Copyright of Thrombosis Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMOGENIC compounds
KW - HEMOSTASIS
KW - HEMORRHAGE
KW - CALIBRATION
KW - Factor VIII:C concentrate
KW - National biological standard
N1 - Accession Number: 13181212; Kang, Hye Na; Email Address: hyena52000@yahoo.co.kr Kim, Soon Nam 1 Lee, Seok Ho 1 Hong, Seung Hwa 1; Affiliation: 1: Biologics Evaluation Department, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Gu, Seoul, South Korea 122-704; Source Info: Mar2004, Vol. 113 Issue 3/4, p261; Subject Term: CHROMOGENIC compounds; Subject Term: HEMOSTASIS; Subject Term: HEMORRHAGE; Subject Term: CALIBRATION; Author-Supplied Keyword: Factor VIII:C concentrate; Author-Supplied Keyword: National biological standard; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.thromres.2004.03.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13181212&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Na, Dong Hee
AU - Cho, Cheong Kwan
AU - Youn, Yu Seok
AU - Choi, Youngju
AU - Lee, Kang Ro
AU - Yoo, Sun Dong
AU - Lee, Kang Choon
T1 - Capillary electrophoresis to characterize ricin and its subunits with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
JO - Toxicon
JF - Toxicon
Y1 - 2004/03//
VL - 43
IS - 3
M3 - Article
SP - 329
SN - 00410101
AB - Capillary electrophoresis (CE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) have been employed as highly efficient methods to characterize ricin, its subunits, and the chemically deglycosylated forms. As a CE method, sodium dodecyl sulfate–capillary gel electrophoresis (SDS–CGE) was used because of its merit over the conventional slab gel techniques. SDS–CGE showed higher resolution capability over other analytical tools in the analysis of the ricin mixture as well as in each of its purified forms. The high resolution was considered to be a result of the presence of carbohydrates on ricin subunits, and this property was useful for identifying the native ricin or its A chain from their chemically deglycosylated forms. However, this method exhibited an overestimation of the molecular mass due to the carbohydrate moieties on ricin subunits, and the inaccuracies were observed to be dependent on the carbohydrate content of the subunits. The exact molecular masses were measured by MALDI-TOF MS, and the results were almost consistent with the expected values. This study clearly illustrates the usefulness and necessity of complementary use of two powerful analytical techniques to characterize ricin and its subunits in a various research fields such as poisoning and immunotoxin research. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAPILLARY electrophoresis
KW - MASS spectrometry
KW - ANTIBODY-toxin conjugates
KW - RICIN
KW - Capillary electrophoresis
KW - Immunotoxin
KW - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
KW - Ricin
KW - Sodium dodecyl sulfate–capillary gel electrophoresis
N1 - Accession Number: 12500611; Na, Dong Hee 1 Cho, Cheong Kwan 1 Youn, Yu Seok 1 Choi, Youngju 2 Lee, Kang Ro 1 Yoo, Sun Dong 1 Lee, Kang Choon 1; Email Address: kclee@skku.edu; Affiliation: 1: Drug Targeting Laboratory, College of Pharmacy, SungKyunKwan University, 300 Chonchon-dong, Jangan-ku, Suwon City 440-746, South Korea 2: Center for Biologics Evaluation, Korea Food and Drug Administration, Seoul, South Korea; Source Info: Mar2004, Vol. 43 Issue 3, p329; Subject Term: CAPILLARY electrophoresis; Subject Term: MASS spectrometry; Subject Term: ANTIBODY-toxin conjugates; Subject Term: RICIN; Author-Supplied Keyword: Capillary electrophoresis; Author-Supplied Keyword: Immunotoxin; Author-Supplied Keyword: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Author-Supplied Keyword: Ricin; Author-Supplied Keyword: Sodium dodecyl sulfate–capillary gel electrophoresis; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxicon.2004.01.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12500611&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Correa-de-Araujo, Rosaly
T1 - A wake-up call to advance women's health
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2004/03//
VL - 14
IS - 2
M3 - Editorial
SP - 31
SN - 10493867
N1 - Accession Number: 12982577; Correa-de-Araujo, Rosaly 1; Email Address: rcorrea@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland, USA; Source Info: Mar2004, Vol. 14 Issue 2, p31; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1016/j.whi.2004.03.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12982577&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-10917-001
AN - 2004-10917-001
AU - Kaftarian, Shakeh
AU - Robinson, Elizabeth
AU - Compton, Wilson
AU - Davis, Beverly Watts
AU - Volkow, Nora
T1 - Blending Prevention Research and Practice in Schools: Critical Issues and Suggestions.
JF - Prevention Science
JO - Prevention Science
JA - Prev Sci
Y1 - 2004/03//
VL - 5
IS - 1
SP - 1
EP - 3
CY - Germany
PB - Springer
SN - 1389-4986
SN - 1573-6695
AD - Kaftarian, Shakeh, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD, US, 20892-9589
N1 - Accession Number: 2004-10917-001. PMID: 15058906 Partial author list: First Author & Affiliation: Kaftarian, Shakeh; National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, US. Release Date: 20040308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse Prevention; Program Development; Schools. Classification: Drug & Alcohol Rehabilitation (3383); Educational/Vocational Counseling & Student Services (3580). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Mar, 2004.
AB - Drug abuse often starts during childhood and adolescence; therefore, prevention strategies need to target these early stages of development. Increasing demands on schools to focus their efforts on the 'basics' has led to what is perceived to be decreased access to schools for prevention research and to diminished interest by schools in investing time and money in science-based prevention interventions. This special issue includes a total of eight articles, six of which grew out of presentations from the meeting. The remaining two were included here because of their direct relevance to the theme of the conference. This introduction provides an overview of all eight articles as well as the suggestions developed in the interactive discussion sessions. In general the articles explore three main themes: (1) the necessity for innovative research designs and methodologies which could have direct bearing on the value and applicability of research-based programs in practice; (2) the importance of building the capacity of practitioners for a successful implementation of research-based programs in real-life settings; and (3) the dynamic tension between fidelity of implementation and program adaptation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention research
KW - prevention strategies
KW - drug abuse
KW - schools
KW - 2004
KW - Drug Abuse Prevention
KW - Program Development
KW - Schools
KW - 2004
DO - 10.1023/B:PREV.0000013975.74774.bc
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10917-001&site=ehost-live&scope=site
UR - jkaftari@nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10205-001
AN - 2004-10205-001
AU - Walrath, Christine M.
AU - Mandell, David S.
AU - Holden, E. Wayne
AU - Santiago, Rolando L.
T1 - Assessing the strengths of children referred for community-based mental health services.
JF - Mental Health Services Research
JO - Mental Health Services Research
JA - Ment Health Serv Res
Y1 - 2004/03//
VL - 6
IS - 1
SP - 1
EP - 8
CY - Germany
PB - Springer
SN - 1522-3434
SN - 1573-6636
AD - Walrath, Christine M., ORC Macro, 116 John Street, Suite 800, New York, NY, US, 10038
N1 - Accession Number: 2004-10205-001. PMID: 15002676 Partial author list: First Author & Affiliation: Walrath, Christine M.; ORC Macro, New York, NY, US. Release Date: 20040217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ability Level; Cognitive Impairment; Community Mental Health Services; Demographic Characteristics. Minor Descriptor: Family Socioeconomic Level; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Behavioral and Emotional Rating Scale: A Strength-Based Approach to Assessment. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2004.
AB - This study investigated the relationship between child strengths and functional impairment, specifically whether youth with greater levels of functional impairment also exhibit strengths. The relationship was investigated for children (N = 1,838) of different genders, ages, race, and ethnic backgrounds and whose families were living at different income levels. A moderate relationship was found between child strengths and functional impairment. Those children with even the most severe functional impairment were rated as having average or near average strengths. With the exception of gender, the relationship between impairment and strengths did not differ as a function of demographic characteristics. These findings provide additional support for the construct validity of the Behavioral and Emotional Strengths Rating Scale (M. Epstein & J. Sharma, 1998) and they highlight the need for strength-based assessment and screening for youth entering mental health services. Child strengths as the foundation for service planning and implementation, and other implications are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - functional impairment
KW - community mental health services
KW - ethnic backgrounds
KW - family income level
KW - child strengths
KW - demographic characteristics
KW - 2004
KW - Ability Level
KW - Cognitive Impairment
KW - Community Mental Health Services
KW - Demographic Characteristics
KW - Family Socioeconomic Level
KW - Mental Health
KW - 2004
DO - 10.1023/B:MHSR.0000011252.84719.f2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10205-001&site=ehost-live&scope=site
UR - christine.m.walrath@orcmacro.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13615-003
AN - 2004-13615-003
AU - Lucksted, Alicia
AU - McGuire, Colleen
AU - Postrado, Leticia
AU - Kreyenbuhl, Julie
AU - Dixon, Lisa B.
T1 - Specifying Cigarette Smoking and Quitting among People with Serious Mental Illness.
JF - The American Journal on Addictions
JO - The American Journal on Addictions
JA - Am J Addict
Y1 - 2004/03//Mar-Apr, 2004
VL - 13
IS - 2
SP - 128
EP - 138
CY - United Kingdom
PB - Taylor & Francis
SN - 1055-0496
SN - 1521-0391
AD - Lucksted, Alicia, Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, 685 West Baltimore Street, MSTF Building, Suite 300, Baltimore, MD, US, 21201
N1 - Accession Number: 2004-13615-003. PMID: 15204664 Partial author list: First Author & Affiliation: Lucksted, Alicia; Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, Baltimore, MD, US. Other Publishers: Informa Healthcare; Wiley-Blackwell Publishing Ltd. Release Date: 20040517. Correction Date: 20150316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Smoking Cessation; Tobacco Smoking. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Fagerstrom Nicotine Dependence Questionnaire; Smoking Decisional Balance Scale DOI: 10.1037/t37783-000; Symptom Checklist-90–Revised DOI: 10.1037/t01210-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Mar-Apr, 2004.
AB - People with serious mental illnesses (SMI) have a high prevalence of cigarette smoking. Details of their smoking and quitting behaviors are needed to create effective interventions. This study aims to describe the smoking and quitting histories, current behaviors, and motivations of an outpatient sample of smokers with SMI. A structured interview and Breathalyzer assessment were administered to 120 smokers from four diverse mental health settings. Participants' smoking and quitting self-report data are presented in combination with demographic and clinical variables; the results provide implications for smoking cessation, amelioration, and prevention interventions and for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cigarette smoking
KW - serious mental illness
KW - 2004
KW - Mental Disorders
KW - Smoking Cessation
KW - Tobacco Smoking
KW - 2004
DO - 10.1080/10550490490436000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13615-003&site=ehost-live&scope=site
UR - aluckste@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12599-008
AN - 2004-12599-008
AU - Kidd, Pamela
AU - Parshall, Mark B.
AU - Wojcik, Susan
AU - Struttmann, Tim
T1 - Assessing Recalibration as a Response-Shift Phenomenon.
JF - Nursing Research
JO - Nursing Research
JA - Nurs Res
Y1 - 2004/03//Mar-Apr, 2004
VL - 53
IS - 2
SP - 130
EP - 135
CY - US
PB - Lippincott Williams & Wilkins
SN - 0029-6562
SN - 1538-9847
AD - Parshall, Mark B., College of Nursing, University of New Mexico, MSC09 5350, 1, Albuquerque, NM, US, 87131-0001
N1 - Accession Number: 2004-12599-008. PMID: 15084998 Partial author list: First Author & Affiliation: Kidd, Pamela; Graduate Programs and Research, College of Nursing, Arizona State University, Tempe, AZ, US. Release Date: 20050222. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Western Institute for Nursing Research Conference, Apr, 2002, Palm Springs, CA. Conference Note: Portions of this research were presented at the aforementioned conference and at the Sigma Theta Tau International Nursing Research Congress, Brisbane, Queensland, Australia, July 2002. Major Descriptor: Measurement; Posttesting; Pretesting; Response Variability. Minor Descriptor: Experiment Controls. Classification: Research Methods & Experimental Design (2260). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Mar-Apr, 2004.
AB - Background: Traditionally, the difference between pretest and posttest scores is used as an estimate of change. This can be problematic when repeated self-report measures are used to assess change resulting from interventions intended to change beliefs, behaviors, attitudes, or values about health or safety. If the intervention is effective, participants may apply more stringent criteria in response to a posttest questionnaire than they did at the pretest. This kind of change has been termed a recalibration response shift. Objectives: To present scale recalibration as a measurable response shift, and to illustrate a method that can be used to estimate its magnitude and direction: the retrospective pretest. Methods: In a quasi-experimental study investigating the effectiveness in small construction companies of narrative simulation exercises targeting back and fall injuries, a retrospective pretest was administered concurrently with a delayed posttest 4 months after the simulation exercises. Results: In the first intervention year, the results from a brief (two-item) retrospective pretest pertaining to safety climate were consistent with a recalibration response shift in the intervention group, but not in the control group. In the second intervention year, when all 10 items of the safety climate questionnaire were used for the retrospective pretest, no evidence of recalibration was found. Conclusions: Although the evidence of recalibration was equivocal, the findings illustrate circumstances in which recalibration response shifts may occur and characteristic patterns of findings may suggest that recalibration has or has not occurred. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - scale recalibration assessment
KW - response-shift
KW - pretest
KW - posttest
KW - 2004
KW - Measurement
KW - Posttesting
KW - Pretesting
KW - Response Variability
KW - Experiment Controls
KW - 2004
DO - 10.1097/00006199-200403000-00009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12599-008&site=ehost-live&scope=site
UR - mparshall@salud.unm.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-01432-003
AN - 2005-01432-003
AU - Berg, Alfred O.
AU - Allen, Janet D.
AU - Frame, Paul
AU - Homer, Charles J.
AU - Johnson, Mark S.
AU - Klein, Jonathan D.
AU - Lieu, Tracy A.
AU - Orleans, C. Tracy
AU - Peipert, Jeffrey F.
AU - Pender, Nola J.
AU - Siu, Albert L.
AU - Teutsch, Steven M.
AU - Westhoff, Carolyn
AU - Woolf, Steven H.
T1 - Screening for Family and Intimate Partner Violence: Recommendation Statement.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2004/03//Mar-Apr, 2004
VL - 2
IS - 2
SP - 156
EP - 160
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Berg, Alfred O., USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2005-01432-003. Partial author list: First Author & Affiliation: Berg, Alfred O.; USPSTF, Department of Family Medicine, University of Washington, Seattle, WA, US. Institutional Authors: U.S. Preventive Services Task Force. Release Date: 20050627. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Domestic Violence; Intimate Partner Violence; Partner Abuse; Screening. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: Mar-Apr, 2004.
AB - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for family and intimate partner violence based on the USPSTF's examination of evidence specific to family and intimate partner violence. It updates the 1996 recommendations contained in the Guide to Clinical Preventive Services, second edition. In 1996, the USPSTF found insufficient evidence to recommend for or against the use of specific instruments to detect domestic violence (a 'C' recommendation according to 1996 grade definitions). The Task Force now uses an explicit process in which the balance of benefits and harms is determined exclusively by the quality and magnitude of the evidence. As a result, current letter grades are based on different criteria than those in 1996. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family violence
KW - partner violence
KW - U.S. Preventive Services Task Force
KW - screening
KW - 2004
KW - Domestic Violence
KW - Intimate Partner Violence
KW - Partner Abuse
KW - Screening
KW - 2004
DO - 10.1370/afm.128
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01432-003&site=ehost-live&scope=site
UR - uspstf@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13031-013
AN - 2004-13031-013
AU - Goldberg, Richard W.
T1 - Hepatitis and HIV screening, education, and treatment for adults with serious mental illness.
JF - General Hospital Psychiatry
JO - General Hospital Psychiatry
JA - Gen Hosp Psychiatry
Y1 - 2004/03//Mar-Apr, 2004
VL - 26
IS - 2
SP - 167
EP - 168
CY - Netherlands
PB - Elsevier Science
SN - 0163-8343
AD - Goldberg, Richard W., Center for Mental Health Services Research, U Maryland-Baltimore, School of Medicine, Baltimore, MD, US, 21201
N1 - Accession Number: 2004-13031-013. PMID: 15038938 Partial author list: First Author & Affiliation: Goldberg, Richard W.; U Maryland, Center for Mental Health Services Research, Baltimore, MD, US. Release Date: 20040426. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Health Screening; Hepatitis; HIV; Mental Disorders; Treatment. Minor Descriptor: Health Education. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 2. Issue Publication Date: Mar-Apr, 2004.
AB - Letter to the editor about hepatitis and HIV screening, education, and treatment for adults with serious mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV screening
KW - serious mental illness
KW - hepatitis
KW - screening
KW - education
KW - treatment
KW - adults
KW - 2004
KW - Health Screening
KW - Hepatitis
KW - HIV
KW - Mental Disorders
KW - Treatment
KW - Health Education
KW - 2004
DO - 10.1016/j.genhosppsych.2003.08.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13031-013&site=ehost-live&scope=site
UR - rgoldber@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-10668-007
AN - 2004-10668-007
AU - Dixon, L.
AU - Lucksted, A.
AU - Stewart, B.
AU - Burland, J.
AU - Brown, C. H.
AU - Postrado, L.
AU - McGuire, C.
AU - Hoffman, M.
T1 - Outcomes of the peer-taught 12-week family-to-family education program for severe mental illness.
JF - Acta Psychiatrica Scandinavica
JO - Acta Psychiatrica Scandinavica
JA - Acta Psychiatr Scand
Y1 - 2004/03//
VL - 109
IS - 3
SP - 207
EP - 215
CY - United Kingdom
PB - Blackwell Publishing
SN - 0001-690X
SN - 1600-0447
AD - Dixon, L., University of Maryland School of Medicine, VA Capitol Health Care Network MIRECC, 685 West Baltimore St MSTF/Room 300, Baltimore, MD, US, 21201
N1 - Accession Number: 2004-10668-007. PMID: 14984393 Partial author list: First Author & Affiliation: Dixon, L.; Center for Mental Health Services Research, University of Maryland, Department of Psychiatry, School of Medicine, Baltimore, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040628. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Caregiver Burden; Educational Program Evaluation; Educational Programs; Family Members; Mental Disorders. Minor Descriptor: Mental Health Services; Self-Care Skills; Severity (Disorders). Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Family Environment Scale [Third Edition Manual]. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2004.
AB - The Family-to-Family Education Program (FFEP) is a 12-week course for family members of adults with serious mental illness (SMI). This study evaluated the effectiveness of FFEP for several family member outcomes. The FFEP enrollees on a waiting list were eligible; 95 consenting family members agreed to four interviews (waitlist, pre- FFEP, post-FFEP, and 6 months post-FFEP) regarding subjective and objective burden, empowerment, and depression. Mixed effects ANOVA models tested hypotheses of decreased burden and increased empowerment after FFEP. The FFEP was associated with reduced subjective burden (P < 0.01) and increased empowerment (P < 0.01) without changes in objective burden. Knowledge about SMI, understanding the mental health system, and self-care also improved. There was no significant decay at 6-month followup. This study provides evidence that FFEP is helpful to relatives of persons with SMI by reducing subjective burden and worry, and increasing empowerment, knowledge about SMI, understanding the mental health system, and self-care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family education program
KW - program evaluation
KW - severe mental illness
KW - caregiver burden
KW - self care
KW - peer education
KW - 2004
KW - Caregiver Burden
KW - Educational Program Evaluation
KW - Educational Programs
KW - Family Members
KW - Mental Disorders
KW - Mental Health Services
KW - Self-Care Skills
KW - Severity (Disorders)
KW - 2004
DO - 10.1046/j.0001-690X.2003.00242.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-10668-007&site=ehost-live&scope=site
UR - ldixon@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11806-009
AN - 2004-11806-009
AU - Harris, Katherine M.
AU - DeVries, Andrea
AU - Dimidjian, Kelli
AU - Pincus, Harold Alan
AU - Tanielian, Terri L.
ED - Pincus, Harold Alan
ED - Tanielian, Terri L.
T1 - Trends in Naltrexone Use Among Members of a Large Private Health Plan.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2004/03//
VL - 55
IS - 3
SP - 221
EP - 221
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Harris, Katherine M., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16-105, Rockville, MD, US, 20857
N1 - Accession Number: 2004-11806-009. PMID: 15001719 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Harris, Katherine M.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20040802. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Health Maintenance Organizations; Naltrexone; Psychosocial Rehabilitation; Health Care Administration. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 1. Issue Publication Date: Mar, 2004.
AB - Naltrexone was approved by the Food and Drug Administration in 1994 as an adjunct to psychosocial therapy for alcohol-dependent and alcohol abusing patients. Clinical evidence suggests that when naltrexone is combined with psychosocial treatment models, it reduces the percentage of days that the patient drinks, reduces the alcohol consumed when the patient does drink, and prevents the patient from relapsing and drinking excessively and destructively. Guidelines recommend that patients use naltrexone daily for three to six months avid up to 24 months on the basis of the patient's preference and compliance with treatment. Existing research suggests that a lack of information, physicians' perceptions that naltrexone is ineffective, and a lack of marketing by the manufacturer help to explain the low rates of naltrexone use. Our data suggest that less than 10 percent of plan members who received alcohol treatment in any setting received naltrexone in any of the three study years. Our data also suggest that a typical patient who initiates naltrexone treatment uses the medication for a substantially shorter period than the recommended guidelines and that trends in the duration of naltrexone use have not changed over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - naltrexone use
KW - private health plan
KW - food and drug administration
KW - psychosocial therapy
KW - alcohol abusing patients
KW - 2004
KW - Alcohol Abuse
KW - Health Maintenance Organizations
KW - Naltrexone
KW - Psychosocial Rehabilitation
KW - Health Care Administration
KW - 2004
DO - 10.1176/appi.ps.55.3.221
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11806-009&site=ehost-live&scope=site
UR - kharris@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12537-010
AN - 2004-12537-010
AU - Hitchcock, Edward M.
AU - Dick, Robert B.
AU - Krieg, Edward F.
T1 - Visual contrast sensitivity testing: A comparison of two F.A.C.T. test types.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2004/03//Mar-Apr, 2004
VL - 26
IS - 2
SP - 271
EP - 277
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Hitchcock, Edward M., U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45226-1998
N1 - Accession Number: 2004-12537-010. PMID: 15019960 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Hitchcock, Edward M.; U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, OH, US. Release Date: 20050228. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Test Reliability; Visual Contrast; Visual Perception. Minor Descriptor: Psychometrics; Visual Acuity. Classification: Sensory & Motor Testing (2221); Visual Perception (2323). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Mar-Apr, 2004.
AB - Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of contrast sensitivity that use similar stimuli, specifically, a hand-held chart and an Optec 1000 vision tester. Monocular contrast sensitivity measures using both tests were obtained from 45 individuals as part of a NIOSH neurobehavioral test-battery appraisal. Test-retest reliability was found to be high for both the hand-held system and the Optec 1000 test (r=.750 and .773, respectively). In comparison to the automated test, the hand-held version produced statistically significant higher contrast sensitivity scores for lower spatial frequencies (1.5 and 3.0 cycles per degree) and lower scores for a relatively higher spatial frequency (18.0 cycles per degree [cpd]). Consequently, this study documents a difference in spatial frequency scores obtained with the hand-held form and Optec 1000 form of contrast sensitivity test, and attributes these differences to design characteristics affecting viewing. It is concluded that caution should be taken when making absolute comparisons of contrast sensitivity test scores between neurobehavioral studies that have used different forms of VCS testing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - visual contrast sensitivity
KW - hand-held chart
KW - Optec 1000 vision tester
KW - visual acuity
KW - test reliability
KW - Functional Acuity Contrast Test
KW - 2004
KW - Test Reliability
KW - Visual Contrast
KW - Visual Perception
KW - Psychometrics
KW - Visual Acuity
KW - 2004
DO - 10.1016/j.ntt.2003.10.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12537-010&site=ehost-live&scope=site
UR - EHitchcock@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15452-003
AN - 2004-15452-003
AU - Cook, Judith A.
T1 - Blazing New Trails: Using Evidence-Based Practice and Stakeholder Consensus to Enhance Psychosocial Rehabilitation Services in Texas.
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2004///Spr 2004
VL - 27
IS - 4
SP - 305
EP - 306
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
N1 - Accession Number: 2004-15452-003. PMID: 15222143 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois, Chicago, IL, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20041025. Correction Date: 20150907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Housing; Mental Health Services; Psychosocial Rehabilitation; Social Skills Training. Classification: Rehabilitation (3380). Population: Human (10). Page Count: 2. Issue Publication Date: Spr 2004.
AB - Presents an introduction to the articles appearing in this special issue. The articles describe a unique initiative undertaken by the Texas Department of Mental Health and Mental Retardation to use best practice along with community consensus in designing a package of psychosocial rehabilitation services for people using public mental health services. In her review of the evidence on supported housing (see record [rid]2004-15452-006[/rid]), Debra Rog argues that affordable housing with an array of supports is backed by both the research literature as well as overwhelming consumer preference. Gary Bond's (see record [rid]2004-15452-007[/rid]) review of supported employment research concludes that the strongest evidence endorses a focus on competitive employment, rapid job search, and integration of mental health and vocational services. Alan Bellack's (see record [rid]2004-15452-009[/rid]) review of research on social skills training, cognitive behavior therapy, and cognitive remediation,finds the strongest evidence base for social skills training. At a time when much is being made about evidence-based practice, this collection of articles acknowledges that research evidence alone will not meet the needs of those faced with designing tomorrow's service systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial rehabilitation services
KW - mental health services
KW - supported housing
KW - social skills training
KW - evidence-based practice
KW - 2004
KW - Evidence Based Practice
KW - Housing
KW - Mental Health Services
KW - Psychosocial Rehabilitation
KW - Social Skills Training
KW - 2004
DO - 10.2975/27.2004.305.306
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15452-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15452-004
AN - 2004-15452-004
AU - Cook, Judith A.
AU - Toprac, Marcia
AU - Shore, Samuel E.
T1 - Combining Evidence-Based Practice with Stakeholder Consensus to Enhance Psychosocial Rehabilitation Services in the Texas Benefit Design Initiative.
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2004///Spr 2004
VL - 27
IS - 4
SP - 307
EP - 318
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Cook, Judith A., UIC Center on Mental Health Services Research and Policy, 104 South Michigan Ave., Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2004-15452-004. PMID: 15222144 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois, Chicago, IL, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20041025. Correction Date: 20150907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Health Care Delivery; Mental Health Services; Psychosocial Rehabilitation. Classification: Rehabilitation (3380). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Spr 2004.
AB - This article describes the use of evidence-based practice along with a multi-stakeholder consensus process to design the psychosocial rehabilitation components in a benefit package of publicly funded mental health services in Texas. The Texas Benefit Design Initiative demonstrates how the combination of science and consensus can be used as a powerful tool for change. It applies the findings of rigorous research regarding psychosocial rehabilitation service delivery approaches that achieve positive outcomes in real world, community settings. At the same time, it makes use of the unique knowledge and experience that mental health service consumers, providers and other advocates can bring to service system design and planning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evidence based practice
KW - psychosocial rehabilitation
KW - mental health services
KW - service delivery
KW - service system design
KW - 2004
KW - Evidence Based Practice
KW - Health Care Delivery
KW - Mental Health Services
KW - Psychosocial Rehabilitation
KW - 2004
DO - 10.2975/27.2004.307.318
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15452-004&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15237-004
AN - 2004-15237-004
AU - Glazer, Sharon
AU - Daniel, Sophie Carole
AU - Short, Kenneth M.
T1 - A study of the relationship between organizational commitment and human values in four countries.
JF - Human Relations
JO - Human Relations
JA - Hum Relat
Y1 - 2004/03//
VL - 57
IS - 3
SP - 323
EP - 345
CY - US
PB - Sage Publications
SN - 0018-7267
SN - 1741-282X
AD - Glazer, Sharon
N1 - Accession Number: 2004-15237-004. Partial author list: First Author & Affiliation: Glazer, Sharon; National Institute of Occupational Safety and Health, US. Release Date: 20040823. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Organizational Commitment; Personal Values. Classification: Organizational Behavior (3660). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: Hungary; Italy; United Kingdom; US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Schwartz's Values Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: Mar, 2004.
AB - Cross-cultural comparisons of the relationship between human values and both continuance commitment (CC) and affective commitment (AC) are presented using data collected from 1259 nurses from Hungary, Italy, the UK, and USA. That correlations between Schwartz's (1992) values and both AC and CC will differ between communal and contractual cultures was partially supported. Moreover, certain values correlate more often with AC or CC depending on the culture one is in. Openness to change values accounted for significant variance in AC in Hungary, Italy and the USA. Pan-culturally, openness to change values partially mediated the effects of countries on AC. It is concluded that values likely influence one's organizational commitment and that the values people endorse might be influenced by national culture. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - organizational commitment
KW - human values
KW - cross-cultural comparisons
KW - continuance commitment
KW - affective commitment
KW - Hungary
KW - Italy
KW - UK
KW - US
KW - 2004
KW - Cross Cultural Differences
KW - Organizational Commitment
KW - Personal Values
KW - 2004
DO - 10.1177/0018726704043271
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15237-004&site=ehost-live&scope=site
UR - shortratt@yahoo.com
UR - sophh@wanadoo.fr
UR - sglazer@email.sjsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12537-016
AN - 2004-12537-016
AU - Scallet, Andrew C.
AU - Kowalke, Pawel K.
AU - Rountree, Robert L.
AU - Thorn, Brett T.
AU - Binienda, Zbigniew K.
T1 - Electroencephalographic, behavioral, and c-fos responses to acute domoic acid exposure.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2004/03//Mar-Apr, 2004
VL - 26
IS - 2
SP - 331
EP - 342
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Scallet, Andrew C., Division of Neurotoxicology, National Center for Toxicological Research, USFDA, 3900 NCTR Drive, Jefferson, AR, US, 72079
N1 - Accession Number: 2004-12537-016. PMID: 15019966 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Scallet, Andrew C.; Division of Neurotoxicology, National Center for Toxicological Research, USFDA, Jefferson, AR, US. Release Date: 20050228. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Acids; Animal Ethology; Drug Dosages; Electroencephalography; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Mar-Apr, 2004.
AB - Domoic acid, a potent excitotoxic analogue of glutamate and kainate, may cause seizures, amnesia, and sometimes death in humans consuming contaminated shellfish. Continuous behavioral observations and recordings of the electrocorticogram (ECoG, via bipolar, epidural electrodes) were obtained from nonanesthetized rats for 2 h after intraperitoneal injection with either saline, 2.2, or 4.4 mg/kg of domoic acid. Rats were then sacrificed for c-fos immunohistochemistry. Fast Fourier transformation (FFT) of the ECoG data to obtain the voltage as a function of frequency indicated that the lower frequency bands (theta, 4.75-6.75 Hz and delta, 1.25-4.50 Hz) were the first to respond, with a significant elevation by 30 min after the high dose of domoic acid. The lower dose of domoic acid also caused a significant elevation of ECoG voltage, but not until later in the session. Sixty minutes after dosing, the behavioral biomarkers of 'ear scratching' and 'rearing, praying' (RP) seizures became significantly elevated in the high-dose rats. The low-dose rats showed no significant alterations in behavior at any time during the session. In postmortem brains obtained immediately after the sessions, c-fos was activated in the anterior olfactory nucleus by both the low and high doses of domoic acid. However, only the high dose increased c-fos immunoreactivity in the hippocampus, affecting both the granule and pyramidal neurons. These data indicate that electroencephalographic and c-fos responses can be obtained at a dose of domoic acid that fails to activate the behavioral response most commonly used as a bioassay for this marine toxin: ear scratching with the ipsilateral foot. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - domoic acid exposure
KW - electroencephalographic responses
KW - behavioral response
KW - rats
KW - drug doses
KW - 2004
KW - Acids
KW - Animal Ethology
KW - Drug Dosages
KW - Electroencephalography
KW - Rats
KW - 2004
DO - 10.1016/j.ntt.2003.10.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12537-016&site=ehost-live&scope=site
UR - AScallet@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11704-011
AN - 2004-11704-011
AU - Robinson, James H.
AU - Haaz, Edward J.
AU - Petrica, Stephen C.
AU - Hillsberg, Bonnie S.
AU - Kennedy, Nancy J.
T1 - Managed Care and Prevention of Mental Health and Substance Abuse Problems: Opportunities for Growth Through Collaboration in the New Millennium.
JF - The Journal of Primary Prevention
JO - The Journal of Primary Prevention
JA - J Prim Prev
Y1 - 2004///Spr 2004
VL - 24
IS - 3
SP - 355
EP - 373
CY - Germany
PB - Springer
SN - 0278-095X
SN - 1573-6547
AD - Petrica, Stephen C., The CDM Group, Inc., 5530 Wisconsin Avenue, Suite 1600, Chevy Chase, MD, US, 20815
N1 - Accession Number: 2004-11704-011. Partial author list: First Author & Affiliation: Robinson, James H.; Strategic Resources Associates, Inc., Sicklersville, NJ, US. Release Date: 20040705. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Managed Care; Mental Health; Primary Mental Health Prevention. Minor Descriptor: Health Care Psychology. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 19. Issue Publication Date: Spr 2004.
AB - Mental health and substance abuse problems impose significant direct and indirect costs on society, yet an increasing number of effective preventive interventions have been identified in the field of behavioral health. Using the Institute of Medicine's 'Continuum of Care' model of prevention, we examine the evolution and future prospects of prevention in the managed care environment. Specific barriers and opportunities for expanding prevention efforts are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse
KW - mental health prevention
KW - managed care
KW - behavioral health
KW - 2004
KW - Drug Abuse
KW - Managed Care
KW - Mental Health
KW - Primary Mental Health Prevention
KW - Health Care Psychology
KW - 2004
DO - 10.1023/B:JOPP.0000018054.94355.eb
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11704-011&site=ehost-live&scope=site
UR - spetrica@cdmgroup.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-11676-002
AN - 2004-11676-002
AU - Aseltine, Robert H. Jr.
AU - DeMartino, Robert
T1 - An Outcome Evaluation of the SOS Suicide Prevention Program.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2004/03//
VL - 94
IS - 3
SP - 446
EP - 451
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Aseltine, Robert H. Jr., Dept of Behavioral Sciences and Community Health, University of Connecticut Health Center, MC 3910, 263 Farmington Ave, Farmington, CT, US, 06030-3910
N1 - Accession Number: 2004-11676-002. PMID: 14998812 Partial author list: First Author & Affiliation: Aseltine, Robert H. Jr.; Department of Behavioral Sciences and Community Health, University of Connecticut Health Center, Farmington, CT, US. Release Date: 20050228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Educational Programs; Program Evaluation; Suicidal Ideation; Suicide; Suicide Prevention. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Mar, 2004.
AB - Objectives: We examined the effectiveness of the Signs of Suicide (SOS) prevention program in reducing suicidal behavior. Methods: 2,100 students in 5 high schools in Columbus, Ga, and Hartford, Conn, were randomly assigned to intervention and control groups. Self-administered questionnaires were completed by students in both groups approximately 3 months after program implementation. Results: Significantly lower rates of suicide attempts and greater knowledge and more adaptive attitudes about depression and suicide were observed among students in the intervention group. The modest changes in knowledge and attitudes partially explained the beneficial effects of the program. Conclusions: SOS is the first school-based suicide prevention program to demonstrate significant reductions in self-reported suicide attempts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention program
KW - suicidal ideation
KW - suicidal behavior
KW - 2004
KW - Educational Programs
KW - Program Evaluation
KW - Suicidal Ideation
KW - Suicide
KW - Suicide Prevention
KW - 2004
DO - 10.2105/AJPH.94.3.446
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-11676-002&site=ehost-live&scope=site
UR - aseltine@uchc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Eswaramoorthy, Subramaniam
AU - Kumaran, Desigan
AU - Keller, James
AU - Swaminathan, Subramanyam
T1 - Role of Metals in the Biological Activity of Clostridium botulinum Neurotoxins.
JO - Biochemistry
JF - Biochemistry
Y1 - 2004/03/02/
VL - 43
IS - 8
M3 - Article
SP - 2209
EP - 2216
SN - 00062960
AB - Clostridium botulinum neurotoxins are the most potent toxins to humans and cause paralysis by blocking neurotransmitter release at the presynaptic nerve terminals. The toxicity involves four steps, viz., binding to neuronal cells, internalization, translocation, and catalytic activity. While the catalytic activity is a zinc endopeptidase activity on the SNARE complex proteins, the translocation is believed to be a pH-dependent process allowing the translocation domain to change its conformation to penetrate the endosomal membrane. Here, we report the crystal structures of botulinum neurotoxin type B at various pHs and of an ape form of the neurotoxin, and discuss the role of metal ions and the effect of pH variation in the biological activity. Except for the perturbation of a few side chains, the conformation of the catalytic domain is unchanged in the zinc-depleted apotoxin, suggesting that zinc's role is catalytic. We have also identified two calcium ions in the molecule and present biochemical evidence to show that they play a role in the translocation of the light chain through the membrane. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXIC agents
KW - NEUROTRANSMITTERS
KW - ENDOPEPTIDASES
KW - BOTULINUM toxin
KW - CLOSTRIDIUM botulinum
KW - POISONS
N1 - Accession Number: 12470738; Eswaramoorthy, Subramaniam 1 Kumaran, Desigan 1 Keller, James 2 Swaminathan, Subramanyam 1; Email Address: swami@bnl.gov; Affiliation: 1: Biology Department, Brookhaven National Laboratory, Upton, New York 11973. 2: Laboratory of Bacterial Toxins, Food and Drug Administration, Bethesda, Maryland 20892.; Source Info: 3/2/2004, Vol. 43 Issue 8, p2209; Subject Term: NEUROTOXIC agents; Subject Term: NEUROTRANSMITTERS; Subject Term: ENDOPEPTIDASES; Subject Term: BOTULINUM toxin; Subject Term: CLOSTRIDIUM botulinum; Subject Term: POISONS; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Depree, G.J.
AU - Siegel, P.D.
T1 - Determination of 3-amino-5-mercapto-1,2,4-triazole in serum
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2004/03/05/
VL - 801
IS - 2
M3 - Article
SP - 359
SN - 15700232
AB - A high performance liquid chromatography (HPLC) method using fluorescence detection to determine 3-amino-5-mercapto-1,2,4-triazole (AMT) levels in serum has been developed. Sample preparation involved treatment with tributylphosphine (TBP) to reduce disulfides formed during storage, precipitation of proteins with acetonitrile (ACN), and precolumn derivatization using the thiol reactive fluorescent probe monobromobimane (MBB). The conjugate (AMT-MBB) was resolved by gradient elution from a C18 reversed-phase column. The assay method was linear over a concentration range of 0.78–50 μg/ml and had a limit of detection (LOD) of 0.05 μg/ml AMT (10 μl injection). This method provides a sensitive and specific tool for the determination of AMT in serum and may have potential industrial hygiene application. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - LIQUID chromatography
KW - FLUORESCENCE
KW - TRIAZOLES
KW - SERUM
KW - PROTEINS
KW - ACETONITRILE
KW - THIOLS
KW - INDUSTRIAL hygiene
KW - 3-Amino-5-mercapto-1,2,4-triazole
N1 - Accession Number: 12039406; Depree, G.J. 1 Siegel, P.D.; Email Address: pds3@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA; Source Info: Mar2004, Vol. 801 Issue 2, p359; Subject Term: HIGH performance liquid chromatography; Subject Term: LIQUID chromatography; Subject Term: FLUORESCENCE; Subject Term: TRIAZOLES; Subject Term: SERUM; Subject Term: PROTEINS; Subject Term: ACETONITRILE; Subject Term: THIOLS; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: 3-Amino-5-mercapto-1,2,4-triazole; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jchromb.2003.11.031
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kang, S.J.
AU - Ryu, S.J.
AU - Chae, J.S.
AU - Eo, S.K.
AU - Woo, G.J.
AU - Lee, J.H.
T1 - Occurrence and characteristics of enterohemorrhagic Escherichia coli O157 in calves associated with diarrhoea
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2004/03/05/
VL - 98
IS - 3/4
M3 - Article
SP - 323
SN - 03781135
AB - Little is known of the association of enterohemorrhagic Escherichia coli O157:H7/NM (EHEC O157) with disease in naturally infected calves, although cattle have been known as a major source for EHEC O157 outbreaks in humans. In this study, we investigated the occurrence of EHEC O157 in calves associated with/without diarrhoea to examine if EHEC O157 is involved in calf diarrhoea and to characterize the isolates. Four hundred and ninety eight diarrhoeic and non-diarrhoeic young calves from 115 different farms were examined. Of 244 diarrhoeic calves, 24 (9.8%) were positive for EHEC O157, and of 254 non-diarrhoeic calves, 7 (2.8%) were positive. EHEC O157 was recovered from 12/76 (15.79%) of diarrhoeic calves less than 2-week-old, and no EHEC O157 was detected in this age group of non-diarrhoeic calves. This implicates EHEC O157 as a possible cause of the disease in naturally infected neonatal calves. The occurrence of EHEC O157 was relatively lower in the older calves (aged older than 8 weeks) and no significant difference was found in the occurrence rates between these diarrhoeic and non-diarrhoeic calves. PCR analysis of virulence markers revealed that the isolates carried various virulence genes such as Ehly, eae, stx1 and stx2, which underlines the potential importance of these attributes for the infection, colonization and possible pathogenesis of calf diarrhoea. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETICS
KW - PHENOTYPE
KW - ESCHERICHIA coli
KW - CALVES
KW - Cattle-bacteria
KW - Diarrhoea
KW - EHEC O157
KW - Escherichia coli
KW - Genetic and phenotypic characteristics
N1 - Accession Number: 12235973; Kang, S.J. 1 Ryu, S.J. 1 Chae, J.S. 1 Eo, S.K. 1 Woo, G.J. 2 Lee, J.H. 1; Email Address: johnhlee@chonbuk.ac.kr; Affiliation: 1: College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University, Chonju 561-756, Republic of Korea 2: Division of Food Microbiology, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Mar2004, Vol. 98 Issue 3/4, p323; Subject Term: GENETICS; Subject Term: PHENOTYPE; Subject Term: ESCHERICHIA coli; Subject Term: CALVES; Author-Supplied Keyword: Cattle-bacteria; Author-Supplied Keyword: Diarrhoea; Author-Supplied Keyword: EHEC O157; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Genetic and phenotypic characteristics; NAICS/Industry Codes: 112111 Beef Cattle Ranching and Farming; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vetmic.2003.11.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, HyeYoung
AU - Lee, JooYong
AU - Kwak, Noh-Jin
AU - Lee, Kweon-Haeng
AU - Rha, SukJoo
AU - Kim, Young-Hoon
AU - Cho, Yong-Yeun
AU - Yang, Ki-Hwa
AU - Kim, KyoungAh
AU - Lim, Young
T1 - Erratum to “Silica induces nuclear factor-κB activation through TAK1 and NIK in Rat2 cell line” [Toxicol. Lett. 143 (3) (2003) 323–330]
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2004/03/07/
VL - 147
IS - 3
M3 - Correction notice
SP - 283
SN - 03784274
N1 - Accession Number: 12170100; Cho, HyeYoung 1; Lee, JooYong 2; Kwak, Noh-Jin 2; Lee, Kweon-Haeng 2,3; Rha, SukJoo 2; Kim, Young-Hoon 2; Cho, Yong-Yeun 4; Yang, Ki-Hwa 4; Kim, KyoungAh 1; Lim, Young 1,5; Email Address: nglim@catholic.ac.kr; Affiliations: 1: Department of Occupational and Environmental Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 2: Research Institute of New Drug Development, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 3: Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; 4: Korea Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea; 5: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-ku, Seoul, South Korea; Issue Info: Mar2004, Vol. 147 Issue 3, p283; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.toxlet.2003.10.019
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ruley, Kristin M.
AU - Ansede, John H.
AU - Pritchett, Christopher L.
AU - Talaat, Adel M.
AU - Reimschuessel, Renate
AU - Trucksis, Michele
T1 - Identification of Mycobacterium marinum virulence genes using signature-tagged mutagenesis and the goldfish model of mycobacterial pathogenesis
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/03/12/
VL - 232
IS - 1
M3 - Article
SP - 75
SN - 03781097
AB - Mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related Mycobacterium species (outside the M. tuberculosis complex) to M. tuberculosis, the etiologic agent of human tuberculosis. Signature-tagged mutagenesis was used to identify genes of M. marinum required for in vivo survival in a goldfish model of mycobacterial pathogenesis. Screening the first 1008 M. marinum mutants led to the identification of 40 putative virulence mutants. DNA sequence analysis of these 40 mutants identified transposon insertions in 35 unique loci. Twenty-eight out of 33 (85%) loci encoding putative virulence genes have homologous genes in M. tuberculosis. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Heredity
KW - Mutation (Biology)
KW - Mycobacterium
KW - Mycobacterial diseases
KW - Goldfish model
KW - Mycobacterium marinum
KW - Pathogenesis
KW - Signature-tagged mutagenesis
KW - Virulence
N1 - Accession Number: 12435416; Ruley, Kristin M. 1; Ansede, John H. 1; Pritchett, Christopher L. 1; Talaat, Adel M. 1; Reimschuessel, Renate 2; Trucksis, Michele 1,3; Email Address: michele.trucksis@umassmed.edu; Affiliations: 1: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA; 2: Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20857, USA; 3: Medical Service, Veterans’ Affairs Medical Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Issue Info: Mar2004, Vol. 232 Issue 1, p75; Thesaurus Term: Heredity; Thesaurus Term: Mutation (Biology); Subject Term: Mycobacterium; Subject Term: Mycobacterial diseases; Author-Supplied Keyword: Goldfish model; Author-Supplied Keyword: Mycobacterium marinum; Author-Supplied Keyword: Pathogenesis; Author-Supplied Keyword: Signature-tagged mutagenesis; Author-Supplied Keyword: Virulence; Language of Keywords: English; Language of Keywords: French; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0378-1097(04)00017-5
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Min Ding
AU - Yongju Lu
AU - Bowman, Linda
AU - Chuanshu Huang
AU - Leonard, Stephen
AU - Liying Wang
AU - Vallyathan, Val
AU - Castranova, Vince
AU - Xianglin Shi
T1 - Inhibition of AP-1 and Neoplastic Transformation by Fresh Apple Peel Extract.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/03/12/
VL - 279
IS - 11
M3 - Article
SP - 10670
EP - 10676
SN - 00219258
AB - Consumption of fruits and vegetables has been associated with a low incidence of cancers and other chronic diseases. Previous studies suggested that fresh apples inhibit tumor cell proliferation. Here we report that oral administration of apple peel extracts decreased the number of nonmalignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz(a)anthracene-initiated mouse skin. ESR analysis indicated that apple extract strongly scavenged hydroxyl (OH) and superoxide (O2...) radicals. Mechanistic studies showed that pretreatment with apple peel extract inhibited AP-1 transactivation induced by ultraviolet B irradiation or TPA in JB6 cells and AP-1-luciferase reporter transgenic mice. This inhibitory effect appears to be mediated by the inhibition of ERKs and JNK activity. The results provide the first evidence that an extract from fresh apple peel extract may inhibit tumor promoter-induced carcinogenesis and associated cell signaling, and suggest that the chemopreventive effects of fresh apple may be through its antioxidant properties by blocking reactive oxygen species-mediated AP-1-MAPK activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Tumors
KW - APPLES
KW - CHRONIC diseases
KW - BIOCHEMISTRY
KW - BIOLOGY
KW - CHEMISTRY
N1 - Accession Number: 12829890; Min Ding 1; Email Address: mid5@cdc.gov Yongju Lu 1 Bowman, Linda 1 Chuanshu Huang 2 Leonard, Stephen 1 Liying Wang 1 Vallyathan, Val 1 Castranova, Vince 1 Xianglin Shi 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Nelson Institute of Environmental Medicine, New York University School of Medicine; Source Info: 3/12/2004, Vol. 279 Issue 11, p10670; Subject Term: SKIN -- Tumors; Subject Term: APPLES; Subject Term: CHRONIC diseases; Subject Term: BIOCHEMISTRY; Subject Term: BIOLOGY; Subject Term: CHEMISTRY; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; Number of Pages: 7p; Illustrations: 6 Color Photographs, 8 Black and White Photographs, 7 Graphs; Document Type: Article
L3 - 10.1074/jbc.M311465200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenman, K. D.
AU - Pechter, E.
AU - Schill, D. P.
AU - Valiante, D. J.
AU - Bresnitz, E. A.
AU - Cummings, K. R.
AU - Socie, E.
AU - Filios, M. S.
T1 - Silicosis in Dental Laboratory Technicians -- Five States, 1994--2000.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/03/12/
VL - 53
IS - 9
M3 - Article
SP - 195
EP - 197
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Describes several cases of silicosis in the U.S. from 1994 to 2000 and underscores the need for employers of dental laboratory technicians to ensure appropriate control of worker exposure to crystalline silica. List of states that reported cases of silicosis; Identification and diagnosis of silicosis in several states; Details of the cases in New Jersey and New York.
KW - SILICOSIS
KW - LUNGS -- Dust diseases
KW - SILICA
KW - DISEASES
KW - UNITED States
N1 - Accession Number: 12679381; Rosenman, K. D. 1 Pechter, E. 2 Schill, D. P. 3 Valiante, D. J. 3 Bresnitz, E. A. 3 Cummings, K. R. 4 Socie, E. 5 Filios, M. S. 6; Affiliation: 1: Michigan State Univ, East Lansing, Michigan 2: Massachusetts Dept of Public Health 3: New Jersey Dept of Health and Senior Svcs. 4: New York State Dept of Health 5: Ohio Dept of Health 6: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 3/12/2004, Vol. 53 Issue 9, p195; Subject Term: SILICOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: SILICA; Subject Term: DISEASES; Subject Term: UNITED States; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Muthyala, Rajeev S.
AU - Ju, Young H.
AU - Sheng, Shubin
AU - Williams, Lee D.
AU - Doerge, Daniel R.
AU - Katzenellenbogen, Benita S.
AU - Helferich, William G.
AU - Katzenellenbogen, John A.
T1 - Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
Y1 - 2004/03/15/
VL - 12
IS - 6
M3 - Article
SP - 1559
SN - 09680896
AB - Equol is a metabolite produced in vivo from the soy phytoestrogen daidzein by the action of gut microflora. It is known to be estrogenic, so human exposure to equol could have significant biological effects. Equol is a chiral molecule that can exist as the enantiomers R-equol and S-equol. To study the biological activity of racemic (±)-equol, as well as that of its pure enantiomers, we developed an efficient and convenient method to prepare (±)-equol from available isoflavanoid precursors. Furthermore, we optimized a method to separate the enantiomers of equol by chiral HPLC, and we studied for the first time, the activities of the enantiomers on the two estrogen receptors, ERα and ERβ. In binding assays, S-equol has a high binding affinity, preferential for ERβ (Ki[ERβ]=16 nM; β/α=13 fold), that is comparable to that of genistein (Ki[ERβ]=6.7 nM; β/α=16), whereas R-equol binds more weakly and with a preference for ERα (Ki[ERα]=50 nM; β/α=0.29). All equol isomers have higher affinity for both ERs than does the biosynthetic precursor daidzein. The availability and the in vitro characterization of the equol enantiomers should enable their biological effects to be studied in detail. [Copyright &y& Elsevier]
AB - Copyright of Bioorganic & Medicinal Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTROGEN receptors
KW - HIGH performance liquid chromatography
KW - BIOSYNTHESIS
KW - CANCER
KW - METABOLITES
KW - Estrogen Receptor (ER)
KW - High Performance Liquid Chromatography (HPLC)
KW - Human Endometrial Carcinoma Cells-1 (HEC-1)
KW - Relative Binding Affinity (RBA)
N1 - Accession Number: 12374818; Muthyala, Rajeev S. 1 Ju, Young H. 2 Sheng, Shubin 3 Williams, Lee D. 4 Doerge, Daniel R. 4 Katzenellenbogen, Benita S. 3 Helferich, William G. 2; Email Address: helferic@staff.uiuc.edu Katzenellenbogen, John A. 1; Email Address: jkatzene@uiuc.edu; Affiliation: 1: Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA 2: Department of Food Science and Human Nutrition, University of Illinois, 905 South Goodwin Avenue, Urbana, IL 61801, USA 3: Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA 4: National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Mar2004, Vol. 12 Issue 6, p1559; Subject Term: ESTROGEN receptors; Subject Term: HIGH performance liquid chromatography; Subject Term: BIOSYNTHESIS; Subject Term: CANCER; Subject Term: METABOLITES; Author-Supplied Keyword: Estrogen Receptor (ER); Author-Supplied Keyword: High Performance Liquid Chromatography (HPLC); Author-Supplied Keyword: Human Endometrial Carcinoma Cells-1 (HEC-1); Author-Supplied Keyword: Relative Binding Affinity (RBA); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bmc.2003.11.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Begier, Elizabeth M.
AU - Burwen, Dale R.
AU - Haber, Penina
AU - Ball, Robert
T1 - Postmarketing Safety Surveillance for Typhoid Fever Vaccines from the Vaccine Adverse Event Reporting System, July 1990 through June 2002.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/03/15/
VL - 38
IS - 6
M3 - Article
SP - 771
EP - 779
SN - 10584838
AB - Vaccines against Salmonella enterica serotype Typhi are used for prophylaxis of international travelers and have potential use as counterbioterrorism agents. The Vaccine Adverse Event Reporting System (VAERS) cannot usually establish causal relationships between vaccines and reported adverse events without further research but has successfully detected unrecognized side effects of vaccine. We reviewed reports to VAERS for US-licensed typhoid fever vaccines for the period of July 1990 through June 2002. We received 321 reports for parenteral Vi capsular polysaccharide vaccine and 345 reports for live, oral, attenuated Ty21a vaccine, with 7.5% and 5.5%, respectively, describing death, hospitalization, permanent disability, or life-threatening illness. Unexpected frequently reported symptoms included dizziness and pruritus for Vi vaccine and fatigue and myalgia for Ty21a vaccine. Gastroenteritis-like illness after receipt of Ty21a vaccine and abdominal pain after receipt of Vi vaccine, which are previously recognized events, occasionally required hospitalization. Nonfatal anaphylaxis was reported after both vaccines. VAERS reports do not indicate any unexpected serious side effects that compromise these vaccines' use for travelers' prophylaxis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Bioterrorism
KW - Vaccination
KW - Salmonella typhi
KW - COMPLICATIONS
KW - Anaphylaxis
KW - Typhoid fever
N1 - Accession Number: 12529895; Begier, Elizabeth M. 1; Burwen, Dale R. 1; Haber, Penina 2; Ball, Robert 1; Email Address: ballr@ cber.fda.gov.; Affiliations: 1: Vaccine Safety Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland.; 2: Immunization Safety Branch, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia; Issue Info: 3/15/2004, Vol. 38 Issue 6, p771; Thesaurus Term: VACCINATION; Thesaurus Term: Bioterrorism; Thesaurus Term: Vaccination; Subject Term: Salmonella typhi; Subject Term: COMPLICATIONS; Subject Term: Anaphylaxis; Subject Term: Typhoid fever; Number of Pages: 9p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kramer, Jeffrey A.
AU - Pettit, Syril D.
AU - Amin, Rupesh P.
AU - Bertram, Timothy A.
AU - Car, Bruce
AU - Cunningham, Michael
AU - Curtis, Sandra W.
AU - Davis, John W.
AU - Kind, Clive
AU - Lawton, Michael
AU - Naciff, Jorge M.
AU - Oreffo, Victor
AU - Roman, Richard J.
AU - Sistare, Frank D.
AU - Stevens, James
AU - Thompson, Karol
AU - Vickers, Alison E.
AU - Wild, Stacey
AU - Afshari, Cynthia A.
T1 - Overview of the Application of Transcription Profiling Using Selected Nephrotoxicants for Toxicology Assessment.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/03/15/
VL - 112
IS - 4
M3 - Article
SP - 460
EP - 464
PB - Superintendent of Documents
SN - 00916765
AB - Microarrays allow for the simultaneous measurement of changes in the levels of thousands of messenger RNAs within a single experiment. As such, the potential for the application of transcription profiling to preclinical safety assessment and mechanism-based risk assessment is profound. However, several practical and technical challenges remain. Among these are nomenclature issues, platform-specific data formats, and the lack of uniform analysis methods and tools. Experiments were designed to address biological, technical, and methodological variability, to evaluate different approaches to data analysis, and to understand the application of the technology to other profiling methodologies and to mechanism-based risk assessment. These goals were addressed using experimental information derived from analysis of the biological response to three mechanistically distinct nephrotoxins: cisplatin, gentamicin, and puromycin aminonucleoside. In spite of the technical challenges, the transcription profiling data yielded mechanistically and topographically valuable information. The analyses detailed in the articles from the Nephrotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute suggest at least equal sensitivity of microarray technology compared to traditional end points. Additionally, microarray analysis of these prototypical nephrotoxicants provided an opportunity for the development of candidate bridging biomarkers of nephrotoxicity. The potential future extension of these applications for risk assessment is also discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Toxins
KW - Biochemical markers
KW - Genetic transcription
KW - Nephrotoxicology
KW - Messenger RNA
N1 - Accession Number: 12791246; Kramer, Jeffrey A. 1; Pettit, Syril D. 2; Email Address: spettit@ilsi.org; Amin, Rupesh P. 3; Bertram, Timothy A. 4; Car, Bruce 5; Cunningham, Michael 3; Curtis, Sandra W. 1; Davis, John W. 6; Kind, Clive 7; Lawton, Michael 4; Naciff, Jorge M. 8; Oreffo, Victor 7; Roman, Richard J. 9; Sistare, Frank D. 10; Stevens, James 11; Thompson, Karol 10; Vickers, Alison E. 12; Wild, Stacey 1,2; Afshari, Cynthia A. 3,13; Affiliations: 1: Pfizer Inc., St. Louis, Missouri, USA; 2: ILSI Health and Environmental Sciences Institute, Washington DC, USA; 3: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.; 4: Pfizer Inc., Groton, Connecticut, USA; 5: Briston-Myers Squibb, Wilmington, Delaware, USA; 6: Schering-Plough Research Institute, Lafayette, New Jersey, USA; 7: AstraZeneca, Charnwood, Leicestershire, United Kingdom; 8: The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio, USA; 9: Medical College of Wisconsin, Milwaukee, Wisconsin, USA; 10: Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, Maryland, USA; 11: Eli Lilly, Greenfield, Indiana, USA; 12: Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA; 13: Amgen Inc., Thousand Oaks, California, USA; Issue Info: Mar2004, Vol. 112 Issue 4, p460; Thesaurus Term: Health risk assessment; Thesaurus Term: Toxins; Thesaurus Term: Biochemical markers; Subject Term: Genetic transcription; Subject Term: Nephrotoxicology; Subject Term: Messenger RNA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Amin, Rupesh P.
AU - Vickers, Alison E.
AU - Sistare, Frank
AU - Thompson, Karol L.
AU - Roman, Richard J.
AU - Lawton, Michael
AU - Kramer, Jeffrey
AU - Hamadeh, Hisham K.
AU - Collins, Jennifer
AU - Grissom, Sherry
AU - Bennett, Lee
AU - Tucker, C. Jeffrey
AU - Wild, Stacie
AU - Kind, Clive
AU - Oreffo, Victor
AU - Davis II, John W.
AU - Curtiss, Sandra
AU - Naciff, Jorge M.
AU - Cunningham, Michael
T1 - Identification of Putative Gene-Based Markers of Renal Toxicity.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/03/15/
VL - 112
IS - 4
M3 - Article
SP - 465
EP - 479
PB - Superintendent of Documents
SN - 00916765
AB - This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined the changes in the expression profile of genes associated with the administration of three different nephrotoxicants—cisplatin, gentamicin, and puromycin—to assess the usefulness of microarrays in the understanding of mechanism(s) of nephrotoxicity. Male Sprague-Dawley rats were treated with daily doses of puromycin (5-20 mg/kg/day for 21 days), gentamicin (2-240 mg/kg/day for 7 days), or a single dose of cisplatin (0.1-5 mg/kg). Groups of rats were sacrificed at various times after administration of these compounds for standard clinical chemistry, urine analysis, and histological evaluation of the kidney. RNA was extracted from the kidney for microarray analysis. Principal component analysis and gene expression-based clustering of compound effects confirmed sample separation based on dose, time, and degree of renal toxicity. In addition, analysis of the profile components revealed some novel changes in the expression of genes that appeared to be associated with injury in specific portions of the nephron and reflected the mechanism of action of these various nephrotoxicants. For example, although puromycin is thought to specifically promote injury of the podocytes in the glomerulus, the changes in gene expression after chronic exposure of this compound suggested a pattern similar to the known proximal tubular nephrotoxicants cisplatin and gentamicin; this prediction was confirmed histologically. We conclude that renal gene expression profiling coupled with analysis of classical end points affords promising opportunities to reveal potential new mechanistic markers of renal toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - Nephrotoxicology
KW - Gene expression
KW - Cisplatin
KW - Gentamicin
KW - Puromycin
N1 - Accession Number: 12792896; Amin, Rupesh P. 1; Vickers, Alison E. 2; Sistare, Frank 3; Thompson, Karol L. 3; Roman, Richard J. 4; Lawton, Michael 5; Kramer, Jeffrey 5; Hamadeh, Hisham K. 1,6; Collins, Jennifer 1; Grissom, Sherry 1; Bennett, Lee 1; Tucker, C. Jeffrey 1; Wild, Stacie 6; Kind, Clive 7; Oreffo, Victor 7; Davis II, John W. 8; Curtiss, Sandra 5; Naciff, Jorge M. 9; Cunningham, Michael 1; Affiliations: 1: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, USA; 2: Novartis Pharmaceuticals Corporation, USA; 3: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, USA; 4: Medical College of Wisconsin and Physiogenix Inc., USA; 5: Pfizer Inc., USA; 6: Amgen Inc., USA; 7: AstraZeneca Inc., UK; 8: Schering-Plough Research Institute, USA; 9: The Procter & Gamble Company, Miami Valley Laboratories, USA; Issue Info: Mar2004, Vol. 112 Issue 4, p465; Thesaurus Term: Biochemical markers; Subject Term: Nephrotoxicology; Subject Term: Gene expression; Subject Term: Cisplatin; Subject Term: Gentamicin; Subject Term: Puromycin; Number of Pages: 15p; Illustrations: 4 Color Photographs, 8 Diagrams, 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rosenzweig, Barry A.
AU - Pine, P. Scott
AU - Domon, Olen E.
AU - Morris, Suzanne M.
AU - Chen, James J.
AU - Sistare, Frank D.
T1 - Dye-Bias Correction in Dual-Labeled cDNA Microarray Gene Expression Measurements
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/03/15/
VL - 112
IS - 4
M3 - Article
SP - 480
EP - 487
PB - Superintendent of Documents
SN - 00916765
AB - A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias. Transcript-dependent dye bias may be due to gene-specific differences of incorporation of two distinctly different chemical dyes and the resultant differential hybridization efficiencies of these two chemically different targets for the same probe. Several approaches were used to assess and minimize the effects of dye bias on fluorescent hybridization signals and maximize the experimental design efficiency of a cell culture experiment. Dye bias was measured at the individual transcript level within each batch of simultaneously processed arrays by replicate dual-labeled split-control sample hybridizations and accounted for a significant component of fluorescent signal differences. This transcript-dependent dye bias alone could introduce unacceptably high numbers of both false-positive and false-negative signals. We found that within a given set of concurrently processed hybridizations, the bias is remarkably consistent and therefore measurable and correctable. The additional microarrays and reagents required for paired technical replicate dye-swap corrections commonly performed to control for dye bias could be costly to end users. Incorporating split-control microarrays within a set of concurrently processed hybridizations to specifically measure dye bias can eliminate the need for technical dye swap replicates and reduce microarray and reagent costs while maintaining experimental accuracy and technical precision. These data support a practical and more efficient experimental design to measure and mathematically correct for dye bias. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hybridization
KW - Antisense DNA
KW - Gene expression
KW - Dyes & dyeing
KW - Cell culture
KW - Genetic transcription
N1 - Accession Number: 12792902; Rosenzweig, Barry A. 1; Email Address: rosenzweigb@cder.fda.gov; Pine, P. Scott 1; Domon, Olen E. 2; Morris, Suzanne M. 2; Chen, James J. 2; Sistare, Frank D. 1; Affiliations: 1: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, USA; 2: National Center for Toxicological Research, U.S. food and Drug Administration, USA; Issue Info: Mar2004, Vol. 112 Issue 4, p480; Thesaurus Term: Hybridization; Subject Term: Antisense DNA; Subject Term: Gene expression; Subject Term: Dyes & dyeing; Subject Term: Cell culture; Subject Term: Genetic transcription; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts, 11 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thompson, Karol L.
AU - Afshari, Cynthia A.
AU - Amin, Rupesh P.
AU - Bertram, Timothy A.
AU - Car, Bruce
AU - Cunningham, Michael
AU - Kind, Clive
AU - Kramer, Jeffrey A.
AU - Lawton, Michael
AU - Mirsky, Michael
AU - Naciff, Jorge M.
AU - Oreffo, Victor
AU - Pine, P. Scott
AU - Sistare, Frank D.
T1 - Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/03/15/
VL - 112
IS - 4
M3 - Article
SP - 488
EP - 494
PB - Superintendent of Documents
SN - 00916765
AB - Within the International Life Sciences Institute Committee on Genomics, a working group was formed to focus on the application of microarray technology to preclinical assessments of drug-induced nephrotoxicity. As part of this effort, Sprague-Dawley rats were treated with the nephrotoxicant cisplatin at doses of 0.3-5 mg/kg over a 4- to 144-hr time course. RNA prepared from these animals was run on a variety of microarray formats at multiple sites. A set of 93 differentially expressed genes associated with cisplatin-induced renal injury was identified on the National Institute of Environmental Health Sciences (NIEHS) custom cDNA microarray platform using quadruplicate measurements of pooled animal RNA. The reproducibility of this profile of statistically significant gene changes on other platforms, in pooled and individual animal replicate samples, and in an independent study was investigated. A good correlation in response between platforms was found among the 48 genes in the NIEHS data set that could be matched to probes on the Affymetrix RGU34A array by UniGene identifier or sequence alignment. Similar results were obtained with genes that could be linked between the NIEHS and Incyte or PHASE-1 arrays. The degree of renal damage induced by cisplatin in individual animals was commensurate with the number of differentially expressed genes in this data set. These results suggest that gene profiles linked to specific types of tissue injury or mechanisms of toxicity and identified in well-performed replicated microarray experiments may be extrapolatable across platform technologies, laboratories, and in-life studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - RNA
KW - Gene expression
KW - Nephrotoxicology
KW - Cisplatin
KW - Rats as laboratory animals
N1 - Accession Number: 12792908; Thompson, Karol L. 1; Email Address: Thompson@cder.fda.gov; Afshari, Cynthia A. 2,3; Amin, Rupesh P. 3; Bertram, Timothy A. 4; Car, Bruce 5; Cunningham, Michael 3; Kind, Clive 6; Kramer, Jeffrey A. 4; Lawton, Michael 4; Mirsky, Michael 4; Naciff, Jorge M. 7; Oreffo, Victor 6; Pine, P. Scott 1; Sistare, Frank D. 1; Affiliations: 1: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, USA; 2: Amgen Inc., USA; 3: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, USA; 4: Pfizer Inc., USA; 5: Bristol-Myers Squibb, USA; 6: AstraZeneca Research and Development, UK; 7: The Procter & Gamble Company, USA; Issue Info: Mar2004, Vol. 112 Issue 4, p488; Thesaurus Term: Biochemical markers; Thesaurus Term: RNA; Subject Term: Gene expression; Subject Term: Nephrotoxicology; Subject Term: Cisplatin; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Al-Khaldi, Sufian F.
AU - Villanueva, Doralis
AU - Chizhikov, Vladimir
T1 - Identification and characterization of Clostridium perfringens using single target DNA microarray chip
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2004/03/15/
VL - 91
IS - 3
M3 - Article
SP - 289
SN - 01681605
AB - A DNA microarray method was developed to identify the presence of toxin genes: encoding beta toxin (cpb), epsilon toxin (etx), enterotoxin (cpe), alpha toxin (cpa), and iota toxin (iA) in Clostridium perfringens. To build the DNA chip, each gene sequence was represented by one ∼22-bp amino-modified oligonucleotide printed twice on aldehyde-coated slides. Multiplex PCR with Cy3 and Cy5-dCTP derivatized fluorescent nucleotides was used to label five genes and fluorescent probes were prepared. The PCR probes were denatured and single-strand-labeled DNAs were separated and purified using magnetic beads. The presence of toxin genes in C. perfringens was detected by hybridization of amplified ssDNA probes to oligonucleotides on the chip representing one target sequence of each toxin gene. The DNA chip was able to identify eight strains of C. perfringens. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Clostridium perfringens
KW - Genes
KW - DNA
KW - Clostridium
KW - Single target DNA microarray chip
KW - Toxin genes
N1 - Accession Number: 12309218; Al-Khaldi, Sufian F. 1; Email Address: Sufian.Al-Khaldi@cfsan.fda.gov; Villanueva, Doralis 1; Chizhikov, Vladimir 2; Affiliations: 1: HFS-517, Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA; 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: Mar2004, Vol. 91 Issue 3, p289; Subject Term: Clostridium perfringens; Subject Term: Genes; Subject Term: DNA; Subject Term: Clostridium; Author-Supplied Keyword: Single target DNA microarray chip; Author-Supplied Keyword: Toxin genes; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2003.07.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bhattacharya, Siddhartha S.
AU - Kulka, Michael
AU - Lampel, Keith A.
AU - Cebula, Thomas A.
AU - Goswami, Biswendu B.
T1 - Use of reverse transcription and PCR to discriminate between infectious and non-infectious hepatitis A virus
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004/03/15/
VL - 116
IS - 2
M3 - Article
SP - 181
SN - 01660934
AB - Hepatitis A virus (HAV) is a major cause of infectious hepatitis worldwide. Detection of HAV in contaminated food or water is a priority research area in laboratories worldwide. Our laboratory has reported previously the development of reverse transcription-polymerase chain reaction (RT-PCR) based detection and typing methods for HAV in contaminated shellfish and produce. It is commonly held that RT-PCR can detect viral genome, but cannot distinguish between infectious and inactivated virus. Therefore, signals obtained after PCR should be considered as false positives unless it can be shown that the sample contains virus capable of infecting a suitable host cell line in culture. We present data to show that this general assumption is not valid. Evidence is provided that demonstrate that signals generated after RT-PCR amplification of viral genome correlated well with the presence of infectious virus in the sample. Viral samples inactivated by heat or UV treatment produced significantly lower signal strength that paralleled infectivity of the sample in cultured cells. The loss of signal strength is most likely the result of damage to the viral RNA that renders it unsuitable for RT-PCR. The correlation between PCR signal and infectivity was better following UV inactivation than heat treatment. The procedure may be adapted to other viruses and inactivating agents. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - COMMUNICABLE diseases
KW - POLYMERASE chain reaction
KW - CELL lines
KW - Discrimination by RT-PCR
KW - Hepatitis A virus
KW - Inactivated
KW - Infectious
N1 - Accession Number: 11959507; Bhattacharya, Siddhartha S. 1 Kulka, Michael 1 Lampel, Keith A. 1 Cebula, Thomas A. 1 Goswami, Biswendu B.; Email Address: bgoswami@cfsan.fda.gov; Affiliation: 1: Division of Molecular Biology, HFS-025, Office of Applied Research and Safety Assessment, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Mar2004, Vol. 116 Issue 2, p181; Subject Term: HEPATITIS A virus; Subject Term: COMMUNICABLE diseases; Subject Term: POLYMERASE chain reaction; Subject Term: CELL lines; Author-Supplied Keyword: Discrimination by RT-PCR; Author-Supplied Keyword: Hepatitis A virus; Author-Supplied Keyword: Inactivated; Author-Supplied Keyword: Infectious; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2003.11.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karrow, N.A.
AU - Guo, T.L.
AU - Delclos, K.B.
AU - Newbold, R.R.
AU - Weis, C.
AU - Germolec, D.R.
AU - White Jr, K.L.
AU - McCay, J. Ann
T1 - Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague–Dawley rats: a two-generation feeding study
JO - Toxicology
JF - Toxicology
Y1 - 2004/03/15/
VL - 196
IS - 3
M3 - Article
SP - 237
SN - 0300483X
AB - Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of certain non-ionic surfactants, and has been reported to have weak estrogen-like activity. As estrogen has immunoregulatory properties and is crucial for normal fetal development, it was hypothesized that adult and developmental exposures to NP had the potential to adversely affect the immune system. Furthermore, developmental exposure to NP might also produce differential immunomodulation in F1 male and female rats. Thus, a two-generation feeding study was conducted to evaluate the potential for NP to modulate certain immune parameters. Pregnant female Sprague–Dawley rats were exposed to NP (0, 25, 500, and 2000 ppm) in their feed for 65 days, beginning 7 days into gestation. The F1 generation male and female offspring were exposed in utero at the respective treatment levels, commencing the 7th day of gestation, and continuing through to 64 days of age. Changes in splenic antibody-forming cell response, natural killer cell activity, and leukocyte numbers were used to evaluate NP immunotoxicity. The results from the present study indicate that dietary exposure to NP can increase splenic natural killer (NK) cell activity and splenocyte subpopulation numbers in the F1 generation rats, without similar changes to the F0 generation. The immunological changes that were observed in the F1 generation also appeared to be gender-specific. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOLS
KW - SURFACE active agents
KW - ESTROGEN
KW - NORTH America
KW - Feeding study
KW - Immunomodulation
KW - In utero exposure
KW - Nonylphenol (NP)
KW - Rat
N1 - Accession Number: 12236437; Karrow, N.A. 1 Guo, T.L. 1 Delclos, K.B. 2 Newbold, R.R. 3 Weis, C. 2 Germolec, D.R. 3 White Jr, K.L. 1; Email Address: kwhite@hsc.vcu.edu McCay, J. Ann 1; Affiliation: 1: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298-6013, USA 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 3: Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA; Source Info: Mar2004, Vol. 196 Issue 3, p237; Subject Term: PHENOLS; Subject Term: SURFACE active agents; Subject Term: ESTROGEN; Subject Term: NORTH America; Author-Supplied Keyword: Feeding study; Author-Supplied Keyword: Immunomodulation; Author-Supplied Keyword: In utero exposure; Author-Supplied Keyword: Nonylphenol (NP); Author-Supplied Keyword: Rat; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2003.11.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yourick, Jeffrey J.
AU - Koenig, Michael L.
AU - Yourick, Debra L.
AU - Bronaugh, Robert L.
T1 - Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption?
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/03/15/
VL - 195
IS - 3
M3 - Article
SP - 309
SN - 0041008X
AB - Recent international guidelines for the conduct of in vitro skin absorption studies put forward different approaches for addressing the status of chemicals remaining in the stratum corneum and epidermis/dermis at the end of a study. The present study investigated the fate of three chemicals [dihydroxyacetone (DHA), 7-(2H-naphtho[1,2-d]triazol-2-yl)-3-phenylcoumarin (7NTPC), and disperse blue 1 (DB1)] in an in vitro absorption study. In these studies, human and fuzzy rat skin penetration and absorption were determined over 24 or 72 h in flow-through diffusion cells. Skin penetration of these chemicals resulted in relatively low receptor fluid levels but high skin levels. For DHA, penetration studies found approximately 22% of the applied dose remaining in the skin (in both the stratum corneum and viable tissue) as a reservoir after 24 h. Little of the DHA that penetrates into skin is actually available to become systemically absorbed. 7NTPC remaining in the skin after 24 h was approximately 14.7% of the applied dose absorbed. Confocal laser cytometry studies with 7NTPC showed that it is present across skin in mainly the epidermis and dermis with intense fluorescence around hair. For DB1, penetration studies found approximately 10% (ethanol vehicle) and 3% (formulation vehicle) of the applied dose localized in mainly the stratum corneum after 24 h. An extended absorption study (72 h) revealed that little additional DB1 was absorbed into the receptor fluid. Skin levels should not be considered as absorbed material for DHA or DB1, while 7NTPC requires further investigation. These studies illustrate the importance of determining the fate of chemicals remaining in skin, which could significantly affect the estimates of systemically available material to be used in exposure estimates. We recommend that a more conclusive means to determine the fate of skin levels is to perform an extended study as conducted for DB1. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSIOLOGY
KW - Skin
KW - Chemicals
KW - Epidermis
KW - Hair -- Dyeing & bleaching
KW - Absorption
KW - Skin
N1 - Accession Number: 12504518; Yourick, Jeffrey J. 1; Email Address: jyourick@cfsan.fda.gov; Koenig, Michael L. 2; Yourick, Debra L. 2; Bronaugh, Robert L. 1; Affiliations: 1: Skin Absorption and Metabolism Section, Cosmetics Toxicology Branch, Office of Cosmetics and Colors, US Food and Drug Administration, Laurel, MD 20708, USA; 2: Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; Issue Info: Mar2004, Vol. 195 Issue 3, p309; Thesaurus Term: PHYSIOLOGY; Subject Term: Skin; Subject Term: Chemicals; Subject Term: Epidermis; Subject Term: Hair -- Dyeing & bleaching; Author-Supplied Keyword: Absorption; Author-Supplied Keyword: Skin; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.taap.2003.07.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wang, Zhihong
AU - Plakas, Steven M.
AU - El Said, Kathleen R.
AU - Jester, Edward L.E.
AU - Granade, H. Ray
AU - Dickey, Robert W.
T1 - LC/MS analysis of brevetoxin metabolites in the Eastern oyster (Crassostrea virginica)
JO - Toxicon
JF - Toxicon
Y1 - 2004/03/15/
VL - 43
IS - 4
M3 - Article
SP - 455
SN - 00410101
AB - Brevetoxin (PbTx) metabolism was examined in the Eastern oyster (Crassostrea virginica) following exposure to a Karenia brevis red tide, by using LC/MS(/MS) and cytotoxicity assay. Metabolites observed in field-exposed oysters were confirmed in oysters exposed to K. brevis cultures in the laboratory. Previously, we identified a cysteine conjugate and its sulfoxide (MH+: m/z 1018 and 1034) as metabolites of the brevetoxin congener PbTx-2. In the present study, we found a cysteine conjugate and its sulfoxide with A-type brevetoxin backbone structure (MH+: m/z 990 and 1006), as probable derivatives of PbTx-1. We also found glycine-cysteine–PbTx (m/z 1047 and 1075), γ-glutamyl-cysteine–PbTx (m/z 1147), and glutathione–PbTx (m/z 1176 and 1204) conjugates with A- and B-type backbone structures. Amino acid–PbTx conjugates react with fatty acids through amide linkage to form a series of fatty acid–amino acid–PbTx conjugates. These fatty acid conjugates are major contributors to the composite cytototoxic responses obtained in extracts of brevetoxin-contaminated oysters. Other brevetoxin derivatives found in oysters are consistent with hydrolytic ring-opening and oxidation/reduction reactions. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - AMERICAN oyster
KW - LIQUID chromatography
KW - MASS spectrometry
KW - Brevetoxins
KW - Cytotoxicity
KW - Eastern oyster
KW - Liquid chromatography/mass spectrometry
KW - Metabolism
N1 - Accession Number: 12639923; Wang, Zhihong 1 Plakas, Steven M.; Email Address: splakas@cfsan.fda.gov El Said, Kathleen R. 1 Jester, Edward L.E. 1 Granade, H. Ray 1 Dickey, Robert W. 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA; Source Info: Mar2004, Vol. 43 Issue 4, p455; Subject Term: METABOLISM; Subject Term: AMERICAN oyster; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Brevetoxins; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: Eastern oyster; Author-Supplied Keyword: Liquid chromatography/mass spectrometry; Author-Supplied Keyword: Metabolism; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.toxicon.2004.02.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kanitz, Mary Helen
AU - Swaminathan, Santhanam
AU - Savage Jr., Russell E.
T1 - Two-dimensional electrophoretic protein profile analysis following exposure of human uroepithelial cells to occupational bladder carcinogens
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/03/18/
VL - 205
IS - 2
M3 - Article
SP - 121
SN - 03043835
AB - Protein biomarkers to occupational carcinogens were investigated using a transformable human uroepithelial cell system, SV-HUC.PC. SV-HUC.PC was treated with N-hydroxy-4,4′-methylene bis (2-chloroaniline) (N-OH-MOCA) or N-hydroxy-4 aminobiphenyl (N-OH-ABP). Two-dimensional gel electrophoresis of cell lysates compared protein changes across treatments. Increasing N-OH-MOCA resulted in a dose-related increase in protein spots altered. Comparing cell profiles treated with either carcinogen revealed alterations in the expression of nine proteins, identified using the TagIdent database. These demonstrated isoelectric point shift (1) or quantity change (8). Our investigation may be useful in identifying biomarkers of effects of exposure to bladder carcinogens. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - PROTEINS
KW - BLADDER
KW - CARCINOGENESIS
KW - Bladder carcinogen
KW - Protein biomarkers
KW - Two-dimensional gel electrophoresis
KW - Uroepithelial cells
N1 - Accession Number: 12310300; Kanitz, Mary Helen 1; Email Address: mhk2@cdc.gov Swaminathan, Santhanam 2 Savage Jr., Russell E. 1; Affiliation: 1: Division of Applied Research and Technology, Taft Laboratory, National Institute for Occupational Safety and Health, MS/C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Department of Pharmacology, University of Wisconsin Medical School, Madison, WI 53706, USA; Source Info: Mar2004, Vol. 205 Issue 2, p121; Subject Term: BIOCHEMICAL markers; Subject Term: PROTEINS; Subject Term: BLADDER; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: Bladder carcinogen; Author-Supplied Keyword: Protein biomarkers; Author-Supplied Keyword: Two-dimensional gel electrophoresis; Author-Supplied Keyword: Uroepithelial cells; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.canlet.2003.09.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manjanatha, M.G.
AU - Shelton, S.D.
AU - Bishop, M.
AU - Shaddock, J.G.
AU - Dobrovolsky, V.N.
AU - Heflich, R.H.
AU - Webb, P.J.
AU - Blankenship, L.R.
AU - Beland, F.A.
AU - Greenlees, K.J.
AU - Culp, S.J.
T1 - Analysis of mutations and bone marrow micronuclei in Big Blue® rats fed leucomalachite green
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/03/22/
VL - 547
IS - 1/2
M3 - Article
SP - 5
SN - 00275107
AB - Leucomalachite green (LMG) is the major metabolite of malachite green (MG), a triphenylmethane dye that has been used widely as an antifungal agent in the fish industry. Concern over MG and LMG is due to the potential for consumer exposure, suggestive evidence of tumor promotion in rodent liver, and suspicion of carcinogenicity based on structure–activity relationships. In order to evaluate the risks associated with exposure to LMG, female Big Blue rats were fed up to 543 ppm LMG; groups of these rats were killed after 4, 16, or 32 weeks of exposure and evaluated for genotoxicity. We previously reported that this treatment resulted in a dose-dependent induction of liver DNA adducts, and that the liver lacI mutant frequency (MF) was increased, but only in rats fed 543 ppm LMG for 16 weeks [Mutation Res. 506/507 (2002) 55–63]. In the present study, we report the results from lymphocyte Hprt mutant assays and bone marrow micronucleus assays performed on these same rats. In addition, we have determined the types of lacI mutations induced in the rats fed 543 ppm LMG for 16 weeks and the rats fed control diet. No significant increases in the frequency of micronuclei or Hprt mutants were observed for any of the doses or time points assayed. Molecular analysis of 80 liver lacI mutants from rats fed 543 ppm LMG for 16 weeks revealed that 21% (17/80) were clonal in origin and that most (55/63) of the independent mutations were base pair substitutions. The predominant type of mutation was G:C→A :T transition (31/63) and the majority (68%) of these involved CpG sites. When corrected for clonality, the 16-week lacI mutation frequency ((36±10)×10−6 ) in treated rats was not significantly different from the clonally corrected control frequency ((17±9)×10−6 ; P=0.06 ). Furthermore, the lacI mutational spectrum in treated rats was not significantly different from that found for control rats (P=0.09 ). Taken together, these data indicate that the DNA adducts produced by LMG in female rats do not result in detectable levels of genotoxicity, and that the increase in lacI MF observed previously in the liver of treated rats may be due to the disproportionate expansion of spontaneous lacI mutations. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALACHITE
KW - METABOLITES
KW - VAT dyes
KW - BONE marrow
KW - MUTATION (Biology)
KW - RATS
KW - Big Blue rats
KW - lacI
KW - Leucomalachite green
KW - Mutant frequency
KW - Mutation frequency
N1 - Accession Number: 12435515; Manjanatha, M.G. 1; Email Address: mmanjanatha@nctr.fda.gov Shelton, S.D. 1 Bishop, M. 1 Shaddock, J.G. 1 Dobrovolsky, V.N. 1 Heflich, R.H. 1 Webb, P.J. 1 Blankenship, L.R. 1 Beland, F.A. 1 Greenlees, K.J. 2 Culp, S.J. 1; Affiliation: 1: Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD 20855, USA; Source Info: Mar2004, Vol. 547 Issue 1/2, p5; Subject Term: MALACHITE; Subject Term: METABOLITES; Subject Term: VAT dyes; Subject Term: BONE marrow; Subject Term: MUTATION (Biology); Subject Term: RATS; Author-Supplied Keyword: Big Blue rats; Author-Supplied Keyword: lacI; Author-Supplied Keyword: Leucomalachite green; Author-Supplied Keyword: Mutant frequency; Author-Supplied Keyword: Mutation frequency; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.11.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mittelstaedt, Roberta A.
AU - Von Tungeln, Linda S.
AU - Shaddock, Joseph G.
AU - Dobrovolsky, Vasily N.
AU - Beland, Frederick A.
AU - Heflich, Robert H.
T1 - Analysis of mutations in the Tk gene of Tk+/− mice treated as neonates with 3′-azido-3′-deoxythymidine (AZT)
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/03/22/
VL - 547
IS - 1/2
M3 - Article
SP - 63
SN - 00275107
AB - Mother-to-child transmission of the human immunodeficiency virus (HIV) is reduced by perinatal treatment with the antiretroviral nucleoside analogue 3′-azido-3′-deoxythymidine (AZT, zidovudine). AZT, however, is genotoxic and carcinogenic in mice when administered either transplacentally or neonatally, suggesting a possible cancer risk for children later in life. In a previous study [Carcinogenesis 23 (2002) 1427–1432] we found that treating B6C3F1/Tk+/− mice on postnatal days 1 through 8 with intraperitoneal injections of 200 mg AZT per kg body weight per day significantly increased spleen lymphocyte mutant frequencies in the autosomal Tk gene. Allele-specific PCR of Tk mutants from treated mice indicated that 61% had lost the Tk+ allele (loss of heterozygosity; LOH), compared with 35% of Tk mutants from control mice, a difference that was significant. In the present study, Tk mutant lymphocyte clones were analyzed further using polymorphic microsatellite markers that flank the Tk gene along the length of mouse chromosome 11. The analysis indicated that allele-loss mutations in control mice were due to either total chromosome loss, mitotic recombination, or both. The pattern of marker loss in mutants from AZT-treated mice differed significantly from the control mice and was consistent with chromosome loss, mitotic recombination, interstitial deletion, gene conversion, and an unusual discontinuous LOH. The results indicate that AZT induced a unique pattern of mutations in the Tk gene of mice and that the major mechanisms of mutation by AZT involved deletion and recombination. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - COMMUNICABLE diseases -- Transmission
KW - MUTATION (Biology)
KW - MATERNAL health services
KW - MOTHER & child
KW - Loss of heterozygosity
KW - Microsatellites
KW - Transgenic mouse model
KW - Zidovudine
N1 - Accession Number: 12435522; Mittelstaedt, Roberta A. 1; Email Address: rmittelstaedt@nctr.fda.gov Von Tungeln, Linda S. 2 Shaddock, Joseph G. 1 Dobrovolsky, Vasily N. 1 Beland, Frederick A. 2 Heflich, Robert H. 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, US FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of Biochemical Toxicology, US FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Mar2004, Vol. 547 Issue 1/2, p63; Subject Term: HIV (Viruses); Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: MUTATION (Biology); Subject Term: MATERNAL health services; Subject Term: MOTHER & child; Author-Supplied Keyword: Loss of heterozygosity; Author-Supplied Keyword: Microsatellites; Author-Supplied Keyword: Transgenic mouse model; Author-Supplied Keyword: Zidovudine; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.12.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12435522&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barić, Ivo
AU - Fumić, Ksenija
AU - Glenn, Byron
AU - Ćuk, Mario
AU - Schulze, Andreas
AU - Finkeistein, James D.
AU - James, S. Jill
AU - Mejaški-Bošnjak, Vlatka
AU - Pažanin, Leo
AU - Pogribny, Igor P.
AU - Radoš, Marko
AU - Sarnavka, Vladimir
AU - Sćukanec-Spoljar, Mira
AU - Allen, Robert H.
AU - Stabler, Sally
AU - Uzelac, Lidija
AU - Vugrek, Oliver
AU - Wagnerd, Conrad
AU - Zeisel, Steven
AU - Mudd, S. Harvey
T1 - S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2004/03/23/
VL - 101
IS - 12
M3 - Article
SP - 4234
EP - 4239
SN - 00278424
AB - We report studies of a Croatian boy, a proven case of human S-adenosylhomocysteine (AdoHcy) hydrolase deficiency. Psychomotor development was slow until his fifth month; thereafter, virtually absent until treatment was started. He had marked hypotonia with elevated serum creatine kinase and transaminases, prolonged prothrombin time and low albumin. Electron microscopy of muscle showed numerous abnormal myelin figures; liver biopsy showed mild hepatitis with sparse rough endoplasmic reticulum. Brain MRI at 12.7 months revealed white matter atrophy and abnormally slow myelination. Hypermethioninemia was present in the initial metabolic study at age 8 months, and persisted (up to 784 μM) without tyrosine elevation. Plasma total homocysteine was very slightly elevated for an infant to 14.5-15.9 μM. In plasma, S-adenosylmethionine was 30-fold and AdoHcy 150-fold elevated. Activity of AdoHcy hydrolase was ≈3% of control in liver and was 5-10% of the control values in red blood cells and cultured fibroblasts. We found no evidence of a soluble inhibitor of the enzyme in extracts of the patient's cultured fibroblasts. Additional pretreatment abnormalities in plasma included low concentrations of phosphatidylcholine and choline, with elevations of guanidinoacetate. betaine, dimethyiglycine, and cystathionine. Leukocyte DNA was hypermethylated. Gene analysis revealed two mutations in exon 4: a maternally derived stop codon, and a paternally derived missense mutation. We discuss reasons for biochemical abnormalities and pathophysiological aspects of AdoHcy hydrolase deficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROLASES
KW - PSYCHOMOTOR disorders
KW - ENZYMES
KW - MOVEMENT disorders
KW - METHIONINE
KW - HOMOCYSTEINE
N1 - Accession Number: 12874250; Barić, Ivo 1; Email Address: i.baric@kbc-zagreb.hr Fumić, Ksenija 2 Glenn, Byron 3 Ćuk, Mario 1 Schulze, Andreas 4 Finkeistein, James D. 5 James, S. Jill 6 Mejaški-Bošnjak, Vlatka 7 Pažanin, Leo 8 Pogribny, Igor P. 9 Radoš, Marko 10 Sarnavka, Vladimir 1 Sćukanec-Spoljar, Mira 11 Allen, Robert H. 12 Stabler, Sally 12 Uzelac, Lidija 13 Vugrek, Oliver 13 Wagnerd, Conrad 3 Zeisel, Steven 14 Mudd, S. Harvey 15; Affiliation: 1: Departments of Pediatrics, University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia. 2: Clinical Institute of Laboratory Diagnosis, University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia. 3: Department of Biochemistry, Vanderbilt University and Department of Veterans Affairs Medical Center, Nashville, TN 37232-01 46. 4: University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany. 5: Veterans Affairs Medical Center and George Washington University, Washington, DC 20422. 6: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202. 7: University Children's Hospital, Klaićeva 16, 10000 Zagreb, Croatia. 8: Departments of Neuropathology, University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia. 9: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. 10: Departments of Radiology, University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia. 11: Departments of Pathology, University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia. 12: Division of Hematology, University of Colorado Health Sciences Center, Denver, CO 80262. 13: Department of Molecular Medicine, Institute "Ruóer Bšković", Bijenička 54, 10000 Zagreb, Croatia. 14: Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599. 15: Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892.; Source Info: 3/23/2004, Vol. 101 Issue 12, p4234; Subject Term: HYDROLASES; Subject Term: PSYCHOMOTOR disorders; Subject Term: ENZYMES; Subject Term: MOVEMENT disorders; Subject Term: METHIONINE; Subject Term: HOMOCYSTEINE; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0400658101
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turesky, Robert J.
AU - Vouros, Paul
T1 - Formation and analysis of heterocyclic aromatic amine–DNA adducts in vitro and in vivo
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2004/03/25/
VL - 802
IS - 1
M3 - Article
SP - 155
SN - 15700232
AB - The detection and quantification of heterocyclic aromatic amine (HAA)–DNA adducts, critical biomarkers in interspecies extrapolation of toxicity data for human risk assessment, remains a challenging analytical problem. The two main analytical methods currently in use to screen for HAA–DNA adducts are the 32P -postlabeling assay and mass spectrometry, using either accelerated mass spectrometry (AMS) or liquid chromatography and electrospray ionization mass spectrometry (LC–ESI–MS). In this review, the principal methods to synthesize and characterize DNA adducts, and the methods applied to measure HAA–DNA adduct in vitro and vivo are discussed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AROMATIC amines
KW - HETEROCYCLIC compounds
KW - BIOCHEMICAL markers
KW - TOXICOLOGY
KW - DNA
KW - MASS spectrometry
KW - LIQUID chromatography
KW - Heterocyclic aromatic amine–DNA adducts
KW - Reviews
KW - DNA
N1 - Accession Number: 12234401; Turesky, Robert J. 1; Email Address: rturesky@nctr.fda.gov Vouros, Paul 2; Affiliation: 1: Division of Chemistry, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Department of Chemistry and Barnett Institute, Northeastern University, Boston, MA 02115, USA; Source Info: Mar2004, Vol. 802 Issue 1, p155; Subject Term: AROMATIC amines; Subject Term: HETEROCYCLIC compounds; Subject Term: BIOCHEMICAL markers; Subject Term: TOXICOLOGY; Subject Term: DNA; Subject Term: MASS spectrometry; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Heterocyclic aromatic amine–DNA adducts; Author-Supplied Keyword: Reviews; Author-Supplied Keyword: DNA; Language of Keywords: English; Language of Keywords: French; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.jchromb.2003.10.053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nomaguchi, Masako
AU - Teramoto, Tadahisa
AU - Li Yu
AU - Markoff, Lewis
AU - Padmanabhan, R.
T1 - Requirements for West Nile Virus (-)- and (+)-Strand Subgenomic RNA Synthesis in Vitro by the Viral RNA-dependent RNA Polymerase Expressed in Escherichia coli.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/03/26/
VL - 279
IS - 13
M3 - Article
SP - 12141
EP - 12151
SN - 00219258
AB - RNA-dependent RNA polymerases (RdRPs) of the Flaviviridae family catalyze replication of positive (+)strand viral RNA through synthesis of minus (-)-and progeny (+)-strand RNAs. West Nile virus (WNV), a mosquito-borne member, is a rapidly re-emerging human pathogen in the United States since its first outbreak in 1999. To study the replication of the WNV RNA in vitro, an assay is described here that utilizes the WNV RdRP and subgenomic (-)- and (+)-strand template RNAs containing 5'- and 3'-terminal regions (TR) with the conserved sequence elements. Our results show that both 5'- and 3'-TRs of the (+)-strand RNA template including the wild type cyclization (CYC) motifs are important for RNA synthesis. However, the 3'-TR of the (-)-strand RNA template alone is sufficient for RNA synthesis. Mutational analysis of the CYC motifs revealed that the (+)-strand 5'-CYC motif is critical for (-)-strand RNA synthesis but neither the (-)-strand 5'- nor 3'-CYC motif is important for the (+)-strand RNA synthesis. Moreover, the 5'-cap inhibits the (-)-strand RNA synthesis from the 3' fold-back structure of (+)-strand RNA template without affecting the de novo synthesis of RNA. These results support a model that "cyclization" of the viral RNA play a role for (-)-strand RNA synthesis but not for (+)-strand RNA synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEST Nile virus
KW - RNA polymerases
KW - ESCHERICHIA coli
KW - MUTATION (Biology)
KW - NUCLEIC acids
KW - RNA
KW - VIRUSES
N1 - Accession Number: 15413072; Nomaguchi, Masako 1 Teramoto, Tadahisa 1 Li Yu 2 Markoff, Lewis 2 Padmanabhan, R. 1; Email Address: rp55@georgetown.edu; Affiliation: 1: Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, D. C. 20057 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 3/26/2004, Vol. 279 Issue 13, p12141; Subject Term: WEST Nile virus; Subject Term: RNA polymerases; Subject Term: ESCHERICHIA coli; Subject Term: MUTATION (Biology); Subject Term: NUCLEIC acids; Subject Term: RNA; Subject Term: VIRUSES; Number of Pages: 11p; Document Type: Article
L3 - 10.1074/jbc.M310839200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salmon, R. L.
T1 - Science in the face of disaster.
JO - Lancet
JF - Lancet
Y1 - 2004/03/27/
VL - 363
IS - 9414
M3 - Book Review
SP - 1084
EP - 1085
PB - Lancet
SN - 00995355
AB - Reviews the book "When food kills: BSE, E. coli and disaster science," by T. Hugh Pennington.
KW - BOVINE spongiform encephalopathy
KW - ESCHERICHIA coli
KW - NONFICTION
KW - PENNINGTON, T. Hugh
KW - WHEN Food Kills: BSE, E.Coli & Disaster Science (Book)
N1 - Accession Number: 12648145; Salmon, R. L. 1; Affiliation: 1: National Public Health Service for Wales, Cardiff, UK; Source Info: 3/27/2004, Vol. 363 Issue 9414, p1084; Subject Term: BOVINE spongiform encephalopathy; Subject Term: ESCHERICHIA coli; Subject Term: NONFICTION; Reviews & Products: WHEN Food Kills: BSE, E.Coli & Disaster Science (Book); People: PENNINGTON, T. Hugh; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Isaguliants, Maria G.
AU - Iakimtchouk, Konstantin
AU - Petrakova, Natalia V.
AU - Yermalovich, Marina A.
AU - Zuber, Anne Kjerrström
AU - Kashuba, Vladimir I.
AU - Belikov, Sergey V.
AU - Andersson, Sören
AU - Kochetkov, Sergey N.
AU - Klinman, Dennis M.
AU - Wahren, Britta
T1 - Gene immunization may induce secondary antibodies reacting with DNA
JO - Vaccine
JF - Vaccine
Y1 - 2004/03/29/
VL - 22
IS - 11/12
M3 - Article
SP - 1576
SN - 0264410X
AB - The fear of autoimmunity in DNA-vaccine recipients initiated screening for anti-DNA antibodies in rabbits immunized with genes of viral nucleic acid-binding and adapter proteins. Of 11 DNA/protein-immunized rabbits, seven had developed secondary antibodies against DNA detected at weeks 11–50 from the on-start of immunization. Two rabbits immunized with HIV-1 reverse transcriptase gene developed transient anti-double-stranded DNA antibodies of high avidity that recognized DNA in the kinetoplasts of Crithidia luciliae. Others developed antibodies reacting with DNA in ELISA and targeting nuclear-associated antigens in the immunofluoresence test. No anti-DNA antibodies were detected at these time-points in any of the controls (P=0.036 ). Induction of anti-DNA antibodies by epitope spreading from protein domains involved in nucleic acid-binding versus maturation of anti-protein antibodies to dual protein-DNA specificity is discussed. (126 words). [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunization
KW - Genes
KW - Immunoglobulins
KW - DNA
KW - amino acid(s) (aa)
KW - Anti-DNA antibodies
KW - core protein of HCV truncated at aa 152 (core152)
KW - DNA immunization
KW - HCV core
KW - HIV-1 reverse transcriptase
KW - human hepatitis C virus (HCV)
KW - human immunodeficiency virus type 1 (HIV-1)
KW - immediate early cytomegalovirus promoter (CMV IE promoter)
KW - native human placental DNA (nDNA)
KW - nef
KW - optical density (OD)
KW - reverse transcriptase of HIV-1 strain HXB-2 (RT)
KW - ribonuclear protein (RNP)
KW - single- and double-stranded DNA (ss- and dsDNA)
KW - stimulation indice (SI)
KW - systemic lupus erythematosus (SLE)
N1 - Accession Number: 12740039; Isaguliants, Maria G. 1,2; Email Address: isaguliats@hotmail.com; Iakimtchouk, Konstantin 1,2; Petrakova, Natalia V. 2; Yermalovich, Marina A. 1; Zuber, Anne Kjerrström 1; Kashuba, Vladimir I. 1; Belikov, Sergey V. 1,3; Andersson, Sören 1,4; Kochetkov, Sergey N. 5; Klinman, Dennis M. 6; Wahren, Britta 1; Affiliations: 1: Swedish Institute for Infectious Disease Control and Microbiology and Tumour Biology Center, Karolinska Institute, SE-171 82 Solna, Sweden; 2: D.I. Ivanovsky Institute of Virology, Gamaleja Str. 16, 123098 Moscow, Russia; 3: Department of Cell Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden; 4: Department of Clinical Microbiology and Immunology, Regionsjukhuset, Örebro Läns Landsting, Örebro SE-70185, Sweden; 5: W.A. Engelhardt Institute of Molecular Biology, Vavilova Str. 32, 117984 Moscow, Russia; 6: Division of Viral Products/CBER, US Food and Drug Administration, Rockville, MD 20902, USA; Issue Info: Mar2004, Vol. 22 Issue 11/12, p1576; Thesaurus Term: Immunization; Subject Term: Genes; Subject Term: Immunoglobulins; Subject Term: DNA; Author-Supplied Keyword: amino acid(s) (aa); Author-Supplied Keyword: Anti-DNA antibodies; Author-Supplied Keyword: core protein of HCV truncated at aa 152 (core152); Author-Supplied Keyword: DNA immunization; Author-Supplied Keyword: HCV core; Author-Supplied Keyword: HIV-1 reverse transcriptase; Author-Supplied Keyword: human hepatitis C virus (HCV); Author-Supplied Keyword: human immunodeficiency virus type 1 (HIV-1); Author-Supplied Keyword: immediate early cytomegalovirus promoter (CMV IE promoter); Author-Supplied Keyword: native human placental DNA (nDNA); Author-Supplied Keyword: nef; Author-Supplied Keyword: optical density (OD); Author-Supplied Keyword: reverse transcriptase of HIV-1 strain HXB-2 (RT); Author-Supplied Keyword: ribonuclear protein (RNP); Author-Supplied Keyword: single- and double-stranded DNA (ss- and dsDNA); Author-Supplied Keyword: stimulation indice (SI); Author-Supplied Keyword: systemic lupus erythematosus (SLE); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.09.033
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hunyady, László
AU - Gáborik, Zsuzsanna
AU - Shah, Bukhtiar H.
AU - Jagadeesh, Gowraganahalli
AU - Clark, Adrian J.L.
AU - Catt, Kevin J.
T1 - Structural determinants of agonist-induced signaling and regulation of the angiotensin AT1 receptor
JO - Molecular & Cellular Endocrinology
JF - Molecular & Cellular Endocrinology
Y1 - 2004/03/31/
VL - 217
IS - 1/2
M3 - Article
SP - 89
EP - 100
SN - 03037207
AB - Angiotensin II (Ang II) regulates aldosterone secretion by stimulating inositol phosphate production and Ca2+ signaling in adrenal glomerulosa cells via the Gq-coupled AT1 receptor, which is rapidly internalized upon agonist binding. Ang II also binds to the heptahelical AT2 receptor, which neither activates inositol phosphate signaling nor undergoes receptor internalization. The differential behaviors of the AT1 and AT2 receptors were analyzed in chimeric angiotensin receptors created by swapping the second (IL2), the third (IL3) intracellular loops and/or the cytoplasmic tail (CT) between these receptors. When transiently expressed in COS-7 cells, the chimeric receptors showed only minor alterations in their ligand binding properties. Measurements of the internalization kinetics and inositol phosphate responses of chimeric AT1A receptors indicated that the CT is required for normal receptor internalization, and IL2 is a determinant of G protein activation. In addition, the amino-terminal portion of IL3 is required for both receptor functions. However, only substitution of IL2 impaired Ang II-induced ERK activation, suggesting that alternative mechanisms are responsible for ERK activation in signaling-deficient mutant AT1 receptors. Substitution of IL2, IL3, or CT of the AT1A receptor into the AT2 receptor sequence did not endow the latter with the ability to internalize or to mediate inositol phosphate signaling responses. These data suggest that the lack of receptor internalization and inositol phosphate signal generation by the AT2 receptor is a consequence of its different activation mechanism, rather than the inability of its cytoplasmic domains to couple to intracellular effectors. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Endocrinology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANGIOTENSINS
KW - CELL receptors
KW - MINERALOCORTICOIDS
KW - SECRETION
KW - Angiotensin II
KW - Ca2+ signaling
KW - Inositol phosphate responses
KW - Receptor internalization
KW - Site-directed mutagenesis
N1 - Accession Number: 13067333; Hunyady, László 1; Email Address: hunyady@puskin.sote.hu Gáborik, Zsuzsanna 1 Shah, Bukhtiar H. 2 Jagadeesh, Gowraganahalli 3 Clark, Adrian J.L. 4 Catt, Kevin J. 2; Affiliation: 1: Department of Physiology, Semmelweis University, Faculty of Medicine, H-1088 Budapest, Hungary 2: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4510, USA 3: Division of Cardio-Renal Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA 4: Department of Endocrinology, Barts & the London, Queen Mary School of Medicine and Dentistry, London EC1A 7BE, UK; Source Info: Mar2004, Vol. 217 Issue 1/2, p89; Subject Term: ANGIOTENSINS; Subject Term: CELL receptors; Subject Term: MINERALOCORTICOIDS; Subject Term: SECRETION; Author-Supplied Keyword: Angiotensin II; Author-Supplied Keyword: Ca2+ signaling; Author-Supplied Keyword: Inositol phosphate responses; Author-Supplied Keyword: Receptor internalization; Author-Supplied Keyword: Site-directed mutagenesis; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.mce.2003.10.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maynard, Andrew D.
AU - Ito, Yasuo
AU - Arslan, Ilke
AU - Zimmer, Anthony T.
AU - Browning, Nigel
AU - Nicholls, Alan
T1 - Examining Elemental Surface Enrichment in Ultrafine Aerosol Particles Using Analytical Scanning Transmission Electron Microscopy.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2004/04//
VL - 38
IS - 4
M3 - Article
SP - 365
EP - 381
SN - 02786826
AB - The surface structure and chemistry of ultrafine aerosol particles (typically particles smaller than 100 nm in diameter) play key roles in determining physical and chemical behavior, and is relevant to fields as diverse as nanotechnology and aerosol toxicity. Analytical scanning transmission electron microscopy (STEM) is one of the few analytical methods available that is potentially capable of characterizing ultrafine particles at subnanometer resolution. We propose a method that enables STEM to characterize and quantify elemental surface enrichment within radially symmetrical particles at a spatial resolution of less than 1 nm when used in conjunction with electron energy loss spectroscopy (EELS) and X-ray energy dispersive spectroscopy (EDS). Although the method relies on a number of assumptions for complete particle characterization, estimation of the depth of an outer layer of elemental enrichment should be possible with relatively few assumptions. A preliminary investigation of the method has been carried out using particles from gas metal arc welding on mild steel. Using the analysis method, we were able to characterize Si and O enrichment in a number of particles. Two particles were investigated extensively using EELS and EDS analysis. Both techniques allowed surface enrichment of Si to be identified and quantified in the particles, although the relatively poor sensitivity of EDS was a limiting factor in the analysis. EELS allowed rapid data collection and enabled surface enrichment of Si and O to be characterized. Using a simple model to describe elemental composition with radial position, it was estimated that Si andOwere enriched in an outer layer around the particle approximately 1 nm deep. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLES
KW - AEROSOLS (Sprays)
KW - SCANNING transmission electron microscopy
KW - ELECTRON energy loss spectroscopy
KW - X-ray spectroscopy
N1 - Accession Number: 51836109; Maynard, Andrew D. 1; Email Address: amaynard@cdc.gov Ito, Yasuo 2 Arslan, Ilke 3 Zimmer, Anthony T. 1 Browning, Nigel 3 Nicholls, Alan 4; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: Northern University Illinois, Department of Physics, DeKalib, Illinois 3: University of Illinois at Chicago, Department of Physics, Chicago, Illinois 4: University of Illinois at Chicago, Research Resources Center, Chicago, Illinois; Source Info: Apr2004, Vol. 38 Issue 4, p365; Subject Term: PARTICLES; Subject Term: AEROSOLS (Sprays); Subject Term: SCANNING transmission electron microscopy; Subject Term: ELECTRON energy loss spectroscopy; Subject Term: X-ray spectroscopy; Number of Pages: 17p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106765384
T1 - Screening for prostate cancer.
AU - Fink K
AU - Clark B
Y1 - 2004/04//4/1/2004
N1 - Accession Number: 106765384. Language: English. Entry Date: 20040813. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Cancer Screening
KW - Prostatic Neoplasms -- Diagnosis
KW - Prostatic Neoplasms -- Prevention and Control
KW - Blacks
KW - Education, Continuing (Credit)
KW - Ethnic Groups
KW - Male
KW - Middle Age
KW - Risk Factors
SP - 1721
EP - 1810
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 69
IS - 7
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - Putting prevention into practice: an evidence-based approach series
SN - 0002-838X
AD - Program Director, US Preventive Services Task Force Center for Primary Care, Prevention, and Clinical Partnerships Agency for Healthcare Research and Quality
U2 - PMID: 15086044.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bodnar, Lisa M.
AU - Nelson, Melissa C.
AU - Mathews, Fiona
AU - Youngman, Linda
AU - Neil, Andrew
T1 - Maternal nutrition and fetal growth: bias introduced because of an inappropriate statistical modeling strategy may explain null findings.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2004/04//
VL - 79
IS - 4
M3 - Article
SP - 525
EP - 527
SN - 00029165
N1 - Accession Number: 94347426; Bodnar, Lisa M. 1; Email Address: bodnar@mwri.magee.edu; Nelson, Melissa C. 2; Email Address: melissa_nelson@unc.edu; Mathews, Fiona 3; Email Address: fiona.mathews@zoology.ox.ac.uk; Youngman, Linda 4; Neil, Andrew 5; Affiliations: 1: Magee-Women's Research Institute 204 Craft Avenue Pittsburgh, PA 15213; 2: Department of Nutrition University of North Carolina School of Public Health Carolina Population Center University of North Carolina Chapel Hill, NC; 3: Department of Zoology University of Oxford South Parks Road Oxford OX1 3PS United Kingdom; 4: Center for Veterinary Medicine Food and Drug Administration Laurel, MD; 5: Division of Public Health and Primary Health Care University of Oxford Institute of Health Sciences Oxford United Kingdom; Issue Info: Apr2004, Vol. 79 Issue 4, p525; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lachenbruch, Peter A.
AU - Rosenberg, Amy S.
AU - Bonvini, Ezio
AU - Cavaillé-Coll, Marc W.
AU - Colvin, Robert B.
T1 - Minireview Biomarkers and Surrogate Endpoints in Renal Transplantation: Present Status and Considerations for Clinical Trial Design.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2004/04//
VL - 4
IS - 4
M3 - Article
SP - 451
EP - 457
PB - Wiley-Blackwell
SN - 16006135
AB - Of major importance in clinical trials is the ability to predict individual patient outcome or endpoints using biomarkers, also known as variables or predictors, in as safe, efficient, and accurate a manner as possible. This review addresses the concepts and possible strategies for use of predictor and surrogate biomarkers in the design of clinical trials in renal transplantation. The statistical concepts apply equally well to other organ grafts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - KIDNEY transplants
KW - TRANSPLANTATION of organs, tissues, etc.
KW - CLINICAL trials
KW - GRAFT rejection
KW - Allograft rejection
KW - predictive variables
KW - surrogate endpoints
N1 - Accession Number: 12540208; Lachenbruch, Peter A. 1 Rosenberg, Amy S. 2,3; Email Address: rosenberg@cber.fda.gov Bonvini, Ezio 4 Cavaillé-Coll, Marc W. 5 Colvin, Robert B. 6; Affiliation: 1: Division of Biostatistics, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, Rockville, MD, USA 2: Division of Therapeutic Proteins, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA 3: Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research 4: Division of Monoclonal Antibodies, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA 5: Division of Special pathogen and Immunologic Drug products, Office of New Drugs, Center for Drugs Evaluation and Research, FDA, Rockville, MD, USA 6: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Source Info: Apr2004, Vol. 4 Issue 4, p451; Subject Term: BIOCHEMICAL markers; Subject Term: KIDNEY transplants; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: CLINICAL trials; Subject Term: GRAFT rejection; Author-Supplied Keyword: Allograft rejection; Author-Supplied Keyword: predictive variables; Author-Supplied Keyword: surrogate endpoints; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1600-6143.2004.00386.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - J. H. Lu
AU - G. Dveksler
AU - G. G. Kaplan
T1 - Rescue of Hepatitis A virus from cDNA-transfected but not virion RNA-transfected mouse Ltk- cells.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2004/04//
VL - 149
IS - 4
M3 - Article
SP - 759
EP - 772
SN - 03048608
AB - Summary. Hepatitis A virus (HAV) has stringent replication requirements and a restricted host-range. Mouse Ltk- cells do not support growth of HAV upon infection or transfection of virion RNA. However, low levels of HAV were rescued from Ltk- cells transiently transfected with its infectious cDNA. Ltk- stable transfectants that expressed HAV antigens and produced infectious HAV were selected and termed Ltk-pJH15 cells. After a few serial passages, HAV became undetectable in the Ltk-pJH15 cells. Multiple rounds of single cell cloning of HAV antigen positive Ltk-pJH15 cells resulted in the isolation of clone E8 that produced higher levels of HAV for at least 5 passages. HAV produced in E8 cells was similar to the parental virus as shown by infectivity assays. Luciferase assays using a bi-cistronic construct containing the HAV 5? noncoding region showed similar levels of HAV IRES-dependent translation in Ltk- and Ltk-pJH15 cells, which suggested that HAV IRES-dependent translation was not a limiting factor for HAV growth in these cells. The availability of the Ltk-pHJ15 cells will allow the identification of cellular factors required for HAV growth, which could lead to the development of a mouse model to study pathogenesis of HAV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - ENTEROVIRUSES
KW - GENE transfection
KW - VIRAL genetics
N1 - Accession Number: 12636300; J. H. Lu 1 G. Dveksler 2 G. G. Kaplan; Affiliation: 1: Laboratory of Hepatitis, Center for Biologics Evaluation and Research, Food and Drug Administration Bethesda Maryland U.S.A. 2: Department of Pathology Uniformed Services University of the Health Sciences Bethesda Maryland U.S.A.; Source Info: Apr2004, Vol. 149 Issue 4, p759; Subject Term: HEPATITIS A virus; Subject Term: ENTEROVIRUSES; Subject Term: GENE transfection; Subject Term: VIRAL genetics; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - C. D. Atreya
AU - S. Kulkarni
AU - K.V. K. Mohan
T1 - Rubella virus P90 associates with the cytokinesis regulatory protein Citron-K kinase and the viral infection and constitutive expression of P90 protein both induce cell cycle arrest following S phase in cell culture.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2004/04//
VL - 149
IS - 4
M3 - Article
SP - 779
EP - 789
SN - 03048608
AB - Summary. In utero infection of developing fetus by Rubella virus (RV) causes cell division inhibition of critical precursor cells in organogenesis, CNS-associated birth defects and induction of apoptosis in cell culture. The underlying mechanisms of RV-induced congenital abnormalities are not known. Here, we identified a novel interaction between RV replicase P90 protein and a cytokinesis-regulatory protein, the Citron-K kinase (CK), in a yeast two-hybrid cDNA library screen. Aberrations in cytokinesis and subsequent apoptosis do occur in specific cell types when the CK gene is knocked out or, its regulatory function is perturbed. Our analysis found that full-length P90 binds CK and in RV-infected cells P90 colocalizes with CK in the cytoplasm. Furthermore, during RV infection as well as cellular expression of P90 alone, we identified a discrete subpopulation of cells containing 4N DNA content, indicating that these cells are arrested in the cell cycle following S phase, suggesting that cellular expression of viral P90 during RV infection perturbs cytokinesis. Previous reports by others established that RV infection leads to apoptosis in cell culture. These observations together taken to the fetal organogenesis level, favor the idea that RV P90, by binding to cellular CK, invokes cell cycle aberrations resulting in the cell- and organ-specific growth inhibition and programmed cell death during RV infection in utero, which commonly is referred to as RV-induced teratogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RUBELLA virus
KW - TOGAVIRUSES
KW - CYTOKINESIS
KW - VIRUS diseases
N1 - Accession Number: 12636309; C. D. Atreya 1 S. Kulkarni 1 K.V. K. Mohan 1; Affiliation: 1: Section of Viral Pathogenesis and Adverse Reactions Laboratory of Pediatric and Respiratory Viral Diseases, Center for Biologics Evaluation and Research Bethesda Maryland U.S.A.; Source Info: Apr2004, Vol. 149 Issue 4, p779; Subject Term: RUBELLA virus; Subject Term: TOGAVIRUSES; Subject Term: CYTOKINESIS; Subject Term: VIRUS diseases; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feldman, Debra M.
AU - Baron, Sherry L.
AU - Bernard, Bruce P.
AU - Lushniak, Boris D.
AU - Banauck, Gisela
AU - Arcentales, Nicole
AU - Kelly, Kerry J.
AU - Prezant, David J.
T1 - Symptoms, Respirator Use, and Pulmonary Function Changes Among New York City Firefighters Responding to the World Trade Center Disaster.
JO - CHEST
JF - CHEST
Y1 - 2004/04//
VL - 125
IS - 4
M3 - Article
SP - 1256
EP - 1264
PB - American College of Chest Physicians
SN - 00123692
AB - New York City firefighters responding to the World Trade Center (WTC) disaster on September 11, 2001, were exposed to numerous hazards. A medical screening program was conducted 3 weeks after the disaster on a sample of firefighters. To determine whether arrival time at the WTC and other exposure variables (including respirator use) were associated with symptoms and changes in pulmonary function During the first 2 weeks at the WTC site, 19% of study firefighters reported not using a respirator; 50% reported using a respirator but only rarely. Prevalence ratios (PRs) for skin, eye, respiratory, and NT symptoms showed a dose-response pattern between exposure groups based on time of arrival at the WTC site, with PRs between 2.6 and 11.4 with 95% confidence intervals (CIs) excluding 1.0 for all but skin symptoms. For those spending > 7 days at the site, the PR for respiratory symptoms was 1.39, (95% CI, 1.13 to 1.55), compared with those who were exposed for < 7 days. Mean spirometry results before and after exposure were within normal limits. The change in spirometry findings (after exposure - before exposure) showed near-equal reductions for FVC and FEV1. These reductions were greater than the annual reductions measured in a referent population of incumbent FDNY firefighters prior to September 11 (p lt 0.05). There was a 60% increased risk of a decline of ≥ 450 mL in FEV1 in those arriving during the first 48 h compared to the referent (p ≤ 0.05). The symptoms and pulmonary function changes following exposure at the WTC demonstrate the need for improvements in respirators and their use, as well as long-term medical monitoring of rescue workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIRE fighters -- Health
KW - SEPTEMBER 11 Terrorist Attacks, 2001
KW - MEDICAL screening
KW - RESPIRATORS (Medical equipment)
KW - LUNG diseases
KW - SPIROMETRY
KW - NEW York (State)
KW - UNITED States
KW - disaster
KW - firefighters
KW - occupational exposure
KW - pulmonary function
KW - world trade center
N1 - Accession Number: 13091178; Feldman, Debra M. 1 Baron, Sherry L. 1 Bernard, Bruce P. 1 Lushniak, Boris D. 1 Banauck, Gisela 2 Arcentales, Nicole 3 Kelly, Kerry J. 3 Prezant, David J. 2; Email Address: prezand@fdny.nyc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 2: Pulmonary Division, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 3: Fire Department of the City of New York, Bureau of Health Services, Brooklyn, NY; Source Info: Apr2004, Vol. 125 Issue 4, p1256; Subject Term: FIRE fighters -- Health; Subject Term: SEPTEMBER 11 Terrorist Attacks, 2001; Subject Term: MEDICAL screening; Subject Term: RESPIRATORS (Medical equipment); Subject Term: LUNG diseases; Subject Term: SPIROMETRY; Subject Term: NEW York (State); Subject Term: UNITED States; Author-Supplied Keyword: disaster; Author-Supplied Keyword: firefighters; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: pulmonary function; Author-Supplied Keyword: world trade center; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Brinker, Allen
AU - Johnston, Michael
T1 - Acute Pulmonary Injury in Association With Amiodarone.
JO - CHEST
JF - CHEST
Y1 - 2004/04//
VL - 125
IS - 4
M3 - Letter
SP - 1591
EP - 1592
PB - American College of Chest Physicians
SN - 00123692
AB - Presents a letter to the editor regarding the association of the drug amiodarone with acute pulmonary injury.
KW - LETTERS to the editor
KW - AMIODARONE
KW - LUNGS -- Wounds & injuries
N1 - Accession Number: 13094942; Brinker, Allen 1; Email Address: brinkera@cder.fda.gov Johnston, Michael 1; Affiliation: 1: Food and Drug Administration, Rockville; Source Info: Apr2004, Vol. 125 Issue 4, p1591; Subject Term: LETTERS to the editor; Subject Term: AMIODARONE; Subject Term: LUNGS -- Wounds & injuries; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106594987
T1 - Symptoms, respirator use, and pulmonary function changes among New York City firefighters responding to the World Trade Center disaster.
AU - Feldman DM
AU - Baron SL
AU - Bernard BP
AU - Lushniak BD
AU - Banauch G
AU - Arcentales N
AU - Kelly KJ
AU - Prezant DJ
Y1 - 2004/04//
N1 - Accession Number: 106594987. Language: English. Entry Date: 20050318. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported by grants from CDC U1Q/CCU221158 and NIOSH RO1-OH07350. NLM UID: 0231335.
KW - Disasters
KW - Firefighters
KW - Occupational Exposure
KW - Rescue Work
KW - Respiratory Tract Diseases -- Diagnosis
KW - Adult
KW - Confidence Intervals
KW - Cough -- Etiology
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Dose-Response Relationship
KW - Health Screening
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - New York
KW - Nonparametric Statistics
KW - Questionnaires
KW - Radiography, Thoracic
KW - Random Sample
KW - Respiratory Function Tests
KW - Respiratory Protective Devices -- Utilization
KW - Respiratory Tract Diseases -- Etiology
KW - T-Tests
KW - Time Factors
KW - Funding Source
KW - Human
SP - 1256
EP - 1264
JO - CHEST
JF - CHEST
JA - CHEST
VL - 125
IS - 4
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - CONTEXT: New York City firefighters responding to the World Trade Center (WTC) disaster on September 11, 2001, were exposed to numerous hazards. A medical screening program was conducted 3 weeks after the disaster on a sample of firefighters. OBJECTIVES: To determine whether arrival time at the WTC and other exposure variables (including respirator use) were associated with symptoms and changes in pulmonary function (after exposure - before exposure). DESIGN: A cross-sectional comparison of firefighters representing the following groups: (1) firefighters who arrived before/during the WTC collapse, (2) firefighters who arrived 1 to 2 days after the collapse, (3) firefighters who arrived 3 to 7 days after the collapse, and (4) unexposed firefighters. SETTING: Fire Department of New York City (FDNY) Bureau of Health Services on October 1 to 5, 2001. POPULATION: A stratified random sample of 362 of 398 recruited working firefighters (91%). Of these, 149 firefighters (41%) were present at the WTC collapse, 142 firefighters (39%) arrived after the collapse but within 48 h, 28 firefighters (8%) arrived 3 to 7 days after the collapse, and 43 firefighters (12%) were unexposed. MAIN OUTCOME MEASURES: New/worsening symptoms involving the eyes, skin, respiratory system, and nose and throat (NT), and changes in spirometry from before to after exposure. RESULTS: During the first 2 weeks at the WTC site, 19% of study firefighters reported not using a respirator; 50% reported using a respirator but only rarely. Prevalence ratios (PRs) for skin, eye, respiratory, and NT symptoms showed a dose-response pattern between exposure groups based on time of arrival at the WTC site, with PRs between 2.6 and 11.4 with 95% confidence intervals (CIs) excluding 1.0 for all but skin symptoms. For those spending > 7 days at the site, the PR for respiratory symptoms was 1.32 (95% CI, 1.13 to 1.55), compared with those who were exposed for < 7 days. Mean spirometry results before and after exposure were within normal limits. The change in spirometry findings (after exposure - before exposure) showed near-equal reductions for FVC and FEV(1). These reductions were greater than the annual reductions measured in a referent population of incumbent FDNY firefighters prior to September 11 (p or= 450 mL in FEV(1) in those arriving during the first 48 h compared to the referent (p 35 years of age. Using data from 1989 to 1999, we compared race-specific age-adjusted incidences, histological distributions, extent of disease at diagnosis, and race-specific survival.Results. During the period of 1989–1999, 2677 women were diagnosed with uterine sarcoma, 2098 (78%) of whom were white and 420 (16%) of whom were black, and 159 (6%) of whom were of other races. The overall age-adjusted incidence for blacks was twice that of whites and more than twice that of women of other races (7/105 vs. 3.6/105 vs. 2.7/105, P < 0.0001). Racial differences in the incidence of uterine sarcoma existed for leiomyosarcoma (1.51/105 for blacks vs. 0.91/105 for whites, and 0.89 for women of other races, P < 0.01) and carcinosarcoma (4.3/105 for blacks, vs. 1.7/105 for whites, and 0.99 for women of other races, P < 0.001), but not for other histological types. Blacks with stage II disease were less likely to receive radiation in addition to surgery compared to whites (33% vs. 54%, P < 0.05). Five-year relative survival of patients with disease beyond the uterus was significantly longer for those that received radiation and surgery compared to those that received surgery alone. There were no racial differences in survival for women that received similar therapy.Conclusions. Adjuvant therapy improved survival for women with stage II–IV disease. Survival of black and white patients who received comparable treatment was similar. [Copyright &y& Elsevier]
AB - Copyright of Gynecologic Oncology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - WOMEN -- Health
KW - TUMORS
KW - CANCER in women
KW - Race
KW - Survival
KW - Uterine sarcoma
N1 - Accession Number: 12638797; Brooks, Sandra E. 1; Email Address: sbrooks@umm.edu Zhan, Min 2 Cote, Timothy 3 Baquet, Claudia R. 2; Affiliation: 1: Department of Obstetrics and Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA 2: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA 3: Food and Drug Administration, Rockville, MD 20857, USA; Source Info: Apr2004, Vol. 93 Issue 1, p204; Subject Term: EPIDEMIOLOGY; Subject Term: WOMEN -- Health; Subject Term: TUMORS; Subject Term: CANCER in women; Author-Supplied Keyword: Race; Author-Supplied Keyword: Survival; Author-Supplied Keyword: Uterine sarcoma; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ygyno.2003.12.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhan, Chunliu
AU - Miller, Marlene R.
AU - Wong, Herbert
AU - Meyer, Gregg S.
T1 - The Effects of HMO Penetration on Preventable Hospitalizations.
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/04//
VL - 39
IS - 2
M3 - Article
SP - 345
EP - 362
PB - Wiley-Blackwell
SN - 00179124
AB - To examine the effects of health maintenance organization (HMO) penetration on preventable hospitalizations. Hospital inpatient discharge abstracts for 932 urban counties in 22 states from the Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID), hospital data from American Hospital Association (AHA) annual survey, and population characteristics and health care capacity data from Health Resources and Services Administration (HRSA) Area Resource File (ARF) for 1998. Preventable hospitalizations due to 14 ambulatory care sensitive conditions were identified using the Agency for Healthcare Research and Quality (AHRQ) Prevention Quality Indicators. Multiple regressions were used to determine the association between preventable hospitalizations and HMO penetration while controlling for demographic and socioeconomic characteristics and health care capacity of the counties. A 10 percent increase in HMO penetration was associated with a 3.8 percent decrease in preventable hospitalizations (95 percent confidence interval, 2.0 percent–5.6 percent). Advanced age, female gender, poor health, poverty, more hospital beds, and fewer primary care physicians per capita were significantly associated with more preventable hospitalizations. Our study suggests that HMO penetration has significant effects in reducing preventable hospitalizations due to some ambulatory care sensitive conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL care
KW - HEALTH maintenance organizations
KW - MEDICAL care
KW - MEDICAL care costs
KW - INPATIENT care
KW - HOSPITALS
KW - HMOs
KW - preventable hospitalizations
KW - quality of care.
N1 - Accession Number: 12284950; Zhan, Chunliu 1 Miller, Marlene R. 2 Wong, Herbert 3 Meyer, Gregg S. 4; Affiliation: 1: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Department of Pediatrics, Johns Hopkins University, Baltimore, MD 3: Agency for Healthcare Research and Quality, Rockville, MD 4: Massachusetts General Hospital, Boston; Source Info: Apr2004, Vol. 39 Issue 2, p345; Subject Term: HOSPITAL care; Subject Term: HEALTH maintenance organizations; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs; Subject Term: INPATIENT care; Subject Term: HOSPITALS; Author-Supplied Keyword: HMOs; Author-Supplied Keyword: preventable hospitalizations; Author-Supplied Keyword: quality of care.; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 18p; Document Type: Article
L3 - 10.1111/j.1475-6773.2004.00231.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barnato, Amber E.
AU - McClellan, Mark B.
AU - Kagay, Christopher R.
AU - Garber, Alan M.
T1 - Practice Patterns Trends in Inpatient Treatment Intensity among Medicare Beneficiaries at the End of Life.
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/04//
VL - 39
IS - 2
M3 - Article
SP - 363
EP - 376
PB - Wiley-Blackwell
SN - 00179124
AB - Although an increasing fraction of Medicare beneficiaries die outside the hospital, the proportion of total Medicare expenditures attributable to care in the last year of life has not dropped. We sought to determine whether disproportionate increases in hospital treatment intensity over time among decedents are responsible for the persistent growth in end-of-life expenditures. The 1985–1999 Medicare Medical Provider Analysis and Review (MedPAR) and Denominator files. We sampled inpatient claims for 20 percent of all elderly fee-for-service Medicare decedents and 5 percent of all survivors between 1985 and 1999 and calculated age-, race-, and gender-adjusted per-capita inpatient expenditures and rates of intensive care unit (ICU) and intensive procedure use. We used the decedent-to-survivor expenditure ratio to determine whether growth rates among decedents outpaced growth relative to survivors, using the growth rate among survivors to control for secular trends in treatment intensity. The data were collected by the Centers for Medicare and Medicaid Services. Real inpatient expenditures for the Medicare fee-for-service population increased by 60 percent, from $58 billion in 1985 to $90 billion in 1999, one-quarter of which were accrued by decedents. Between 1985 and 1999 the proportion of beneficiaries with one or more intensive care unit (ICU) admission increased from 30.5 percent to 35.0 percent among decedents and from 5.0 percent to 7.1 percent among survivors; those undergoing one or more intensive procedure increased from 20.9 percent to 31.0 percent among decedents and from 5.8 percent to 8.5 percent among survivors. The majority of intensive procedures in the United States were performed in the more numerous survivors, although in 1999 50 percent of feeding tube placements, 60 percent of intubations/tracheostomies, and 75 percent of cardiopulmonary resuscitations were in decedents. The proportion of beneficiaries dying in a hospital decreased from 44.4 percent to 39.3 percent, but the likelihood of being admitted to an ICU or undergoing an intensive procedure during the terminal hospitalization increased from 38.0 percent to 39.8 percent and from 17.8 percent to 30.3 percent, respectively. One in five Medicare beneficiaries who died in the hospital in 1999 received mechanical ventilation during their terminal admission. Inpatient treatment intensity for all fee-for-service beneficiaries increased between 1985 and 1999 regardless of survivorship status. Absolute changes in per-capita hospital expenditures, ICU admissions, and intensive inpatient procedure use were much higher among decedents. Relative changes were similar except for ICU admissions, which grew faster among survivors. The secular decline in in-hospital deaths has not resulted in decreased per capita utilization of expensive inpatient services in the last year of life. This could imply that net hospital expenditures for the dying might have been even higher over this time period if the shift toward hospice had not occurred. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE beneficiaries
KW - INPATIENT care
KW - MEDICARE
KW - MEDICAL care costs
KW - HOSPITALS
KW - THERAPEUTICS
KW - elderly
KW - end of life
KW - health care expenditures
KW - intensive care.
KW - Medicare
N1 - Accession Number: 12284949; Barnato, Amber E. 1 McClellan, Mark B. 2 Kagay, Christopher R. 3 Garber, Alan M. 4; Affiliation: 1: Medicine and Health Policy and Management, University of Pittsburgh, 230 McKee Place, Pittsburgh, PA 15213 2: Stanford University School of Medicine, Stanford, CA, and the United States Food and Drug Administration, Washington, DC 3: UCSF School of Medicine, San Francisco, CA 4: Stanford University School of Medicine, the Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, and the National Bureau of Economic Research, Inc., Palo Alto, CA; Source Info: Apr2004, Vol. 39 Issue 2, p363; Subject Term: MEDICARE beneficiaries; Subject Term: INPATIENT care; Subject Term: MEDICARE; Subject Term: MEDICAL care costs; Subject Term: HOSPITALS; Subject Term: THERAPEUTICS; Author-Supplied Keyword: elderly; Author-Supplied Keyword: end of life; Author-Supplied Keyword: health care expenditures; Author-Supplied Keyword: intensive care.; Author-Supplied Keyword: Medicare; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 14p; Document Type: Article
L3 - 10.1111/j.1475-6773.2004.00232.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106593462
T1 - The effects of HMO penetration on preventable hospitalizations.
AU - Zhan C
AU - Miller MR
AU - Wong H
AU - Meyer GS
Y1 - 2004/04//
N1 - Accession Number: 106593462. Language: English. Entry Date: 20050311. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Health Maintenance Organizations
KW - Hospitalization
KW - Adolescence
KW - Adult
KW - Aged
KW - Ambulatory Care
KW - Clinical Indicators
KW - Correlation Coefficient
KW - Descriptive Statistics
KW - Health Resource Utilization
KW - Health Services Research
KW - Middle Age
KW - Patient Discharge
KW - Preventive Health Care
KW - Regression
KW - Surveys
KW - United States
KW - Human
SP - 345
EP - 361
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 39
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVE: To examine the effects of health maintenance organization (HMO) penetration on preventable hospitalizations. DATA SOURCE: Hospital inpatient discharge abstracts for 932 urban counties in 22 states from the Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID), hospital data from American Hospital Association (AHA) annual survey, and population characteristics and health care capacity data from Health Resources and Services Administration (HRSA) Area Resource File (ARF) for 1998. METHODS: Preventable hospitalizations due to 14 ambulatory care sensitive conditions were identified using the Agency for Healthcare Research and Quality (AHRQ) Prevention Quality Indicators. Multiple regressions were used to determine the association between preventable hospitalizations and HMO penetration while controlling for demographic and socioeconomic characteristics and health care capacity of the counties. PRINCIPAL FINDINGS: A 10 percent increase in HMO penetration was associated with a 3.8 percent decrease in preventable hospitalizations (95 percent confidence interval, 2.0 percent-5.6 percent). Advanced age, female gender, poor health, poverty, more hospital beds, and fewer primary care physicians per capita were significantly associated with more preventable hospitalizations. CONCLUSIONS: Our study suggests that HMO penetration has significant effects in reducing preventable hospitalizations due to some ambulatory care sensitive conditions.
SN - 0017-9124
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850
U2 - PMID: 15032958.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - M. Ak
AU - A. Babaoğlu
AU - H. Dağci
AU - M. Türk
AU - S. Bayram
AU - H. Ertabaklar
AU - M. A. Özcel
AU - A. Üner
AU - Y. Charoenvit
AU - S. Kumar
AU - S. L. Hoffman
T1 - Production of Monoclonal Antibodies Against a 19-kD Recombinant Plasmodium vivax MSP1 for Detection of P. vivax Malaria in Turkey.
JO - Hybridoma & Hybridomics
JF - Hybridoma & Hybridomics
Y1 - 2004/04//
VL - 23
IS - 2
M3 - Article
SP - 133
EP - 136
SN - 15368599
AB - Plasmodium vivax malaria, which is transmitted to humans by mosquitoes, is one of the most important parasitic diseases in Turkey. The major protein on the surface of asexual erythrocytic stage merozoites of P. vivax (Pv) is 200 kD and called major merozoite surface protein-1 (PvMSP1). Polyclonal antibodies against the 19-kD C-terminal fragment of PvMSP1 (PvMSP119) are protective in monkey models of P. vivax and associated with protection in field studies. In this research, monoclonal antibodies were produced against PvMSP119. A total of 214 IgG1 antibody-releasing hybridomas were obtained and three monoclonal antibodies were produced (PvMSP119.1, PvMSP119.2, and PvMSP119.3) and selected for further study. They have now been purified from ascitic fluid on a Staphylococcus protein A affinity column.These are the first monoclonal antibodies produced against P. vivax in Turkey and the first monoclonal antibodies produced against this recombinant PvMSP119 in the world. The monoclonal antibodies will be used to study the epidemiology of P. vivax in patients with malaria in Turkey, and to develop better strategies for early diagnosis and treatment of the disease in our population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hybridoma & Hybridomics is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - MALARIA
KW - TURKEY
N1 - Accession Number: 19985060; M. Ak 1 A. Babaoğlu 1 H. Dağci 1 M. Türk 2 S. Bayram 3 H. Ertabaklar 4 M. A. Özcel 1 A. Üner 1 Y. Charoenvit 5 S. Kumar 6 S. L. Hoffman 7; Affiliation: 1: Department of Parasitology, Ege Univ. Med. Fac., Bornova, Izmir, Turkey 2: Microbiology Lab, Izmir State Hospital, Yesilyurt, Izmir, Turkey 3: Department of Parasitology, 9 Eylül Univ. Med. Fac., Inciralti, Izmir, Turkey 4: Department of Parasitology, Adnan Menderes Univ. Med. Fac., Aydin, Turkey 5: Malaria Program, IDD, NMRC, Silver Spring, Maryland 6: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 7: Sanaria Inc., Rockville, Maryland; Source Info: Apr2004, Vol. 23 Issue 2, p133; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: MALARIA; Subject Term: TURKEY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guor-Cheng Fang
AU - Yuh-Shen Wu
AU - Winn-Jung Huang
AU - Hsin-Chung Lu
AU - Pi-Cheng Fu, Peter
AU - Yuh-Shuen Chen
T1 - Short-term variations in ambient particulates and their sources in Taichung, Taiwan.
JO - International Journal of Environment & Pollution
JF - International Journal of Environment & Pollution
Y1 - 2004/04//
VL - 21
IS - 4
M3 - Article
SP - 383
EP - 395
SN - 09574352
AB - Ambient particulate measurements were carried out using TE-PUF sampling and a Universal Air Sampler between 8 March and 25 April 2001 at Taichung. Samples were collected every 6 hours beginning at 0100 LST (Local Standard Time) each day at two sites, one at a university campus and the other at a roadside. Chemical species (CI-, NO3-, SO4[2,-], Na+, NH4+,K+, Mg+,Ca[2,+],Fe, Zn, Pb, Ni) were analysed simultaneously. The main sources at the campus sampling site were identified as soil dust re-suspension, sea salt spray, secondary aerosols and zinc-related industry, and those at the traffic sampling site as soil dust re-suspension, sea salt spray, secondary aerosol and fuel combustion. The diurnal variation of all the chemical species' concentrations were also measured. The meteorological conditions and the pollutant emission sources near the sampling sites are likely impact factors. These results also showed that the short-term diurnal variation of the concentrations of chemical species in the ambient suspended particulates is useful to identify the sources and modes of formation of the particulates. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Environment & Pollution is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Air pollution
KW - Dust
KW - Pollution
KW - Sea salt
KW - diurnal variation
KW - fine and coarse particulates
KW - PCA
KW - short-term variation
KW - TSP
N1 - Accession Number: 13829895; Guor-Cheng Fang 1; Email Address: gcfang@sunrise.hk.edu.tw; Yuh-Shen Wu 1; Winn-Jung Huang 1; Hsin-Chung Lu 1; Pi-Cheng Fu, Peter 2; Yuh-Shuen Chen 3; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan, R.O.C.; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; 3: Department of Food Nutrition, Hungkuang University, Sha-Lu, Taichung 433, Taiwan, R.O.C.; Issue Info: 2004, Vol. 21 Issue 4, p383; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Air pollution; Thesaurus Term: Dust; Thesaurus Term: Pollution; Subject Term: Sea salt; Author-Supplied Keyword: diurnal variation; Author-Supplied Keyword: fine and coarse particulates; Author-Supplied Keyword: PCA; Author-Supplied Keyword: short-term variation; Author-Supplied Keyword: TSP; Number of Pages: 17p; Illustrations: 5 Charts, 6 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 104738516
T1 - Correlates of coping with perceived discriminatory experiences among African American adolescents.
AU - Scott Jr, Lionel D
Y1 - 2004/04//
N1 - Accession Number: 104738516. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7808986.
KW - Adaptation, Psychological
KW - Adolescent Behavior
KW - Blacks -- Psychosocial Factors
KW - Prejudice
KW - Adolescence
KW - Alabama
KW - Family Characteristics
KW - Female
KW - Human
KW - Male
KW - Sex Factors
KW - Social Class
KW - Stress, Psychological
SP - 123
EP - 137
JO - Journal of Adolescence
JF - Journal of Adolescence
JA - J ADOLESC
VL - 27
IS - 2
CY - Burlington, Massachusetts
PB - Academic Press Inc.
SN - 0140-1971
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130, USA. lscott@gwbmail.wustl.edu
U2 - PMID: 15023512.
DO - 10.1016/j.adolescence.2003.11.005
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moore, C.
AU - Clark, E.M.
AU - Gallimore, C.I.
AU - Corden, S.A.
AU - Gray, J.J.
AU - Westmoreland, D.
T1 - Evaluation of a broadly reactive nucleic acid sequence based amplification assay for the detection of noroviruses in faecal material
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2004/04//
VL - 29
IS - 4
M3 - Article
SP - 290
SN - 13866532
AB - A recently described nucleic acid sequence based amplification (NASBA) assay for the detection of genogroup I (GI) and genogroup II (GII) norovirus RNA in faecal samples was evaluated against a reverse transcription polymerase chain reaction (RT-PCR). Both assays were used to screen a panel of 38 faecal samples known to contain 17 different norovirus strains and 131 clinical samples collected from 60 gastroenteritis outbreaks of unknown aetiology.The NASBA assay detected 13 out of the 17 strains of norovirus in the characterised panel, failing to detect a single GII strain and three GI strains. There was 90% agreement between the two assays used to detect norovirus in clinical samples from outbreaks. NASBA detected norovirus RNA in all 64 samples positive by RT-PCR and also detected norovirus RNA in additional 13 samples that were negative by RT-PCR. The sensitivity and specificity of NASBA was 100% and 80%, respectively, compared to RT-PCR results.The norovirus NASBA assay was shown to be highly sensitive and specific, and its ease of use and rapid turnaround time makes it a favourable alternative to RT-PCR for the investigation of norovirus outbreaks. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - RNA
KW - FECES
KW - POLYMERASE chain reaction
KW - GASTROENTERITIS
KW - GASTROINTESTINAL diseases
KW - VIRUSES
KW - Faeces
KW - NLV
KW - Norwalk-like virus
KW - SRSV
KW - Viral gastroenteritis
N1 - Accession Number: 12382422; Moore, C. 1; Email Address: catherine.moore@nphs.wales.nhs.uk Clark, E.M. 1 Gallimore, C.I. 2 Corden, S.A. 1 Gray, J.J. 2 Westmoreland, D. 1; Affiliation: 1: National Public Health Service for Wales Microbiology Cardiff, Specialist Virology Centre, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK 2: Enteric Virus Unit, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London NW9 5HT, UK; Source Info: Apr2004, Vol. 29 Issue 4, p290; Subject Term: NUCLEIC acids; Subject Term: RNA; Subject Term: FECES; Subject Term: POLYMERASE chain reaction; Subject Term: GASTROENTERITIS; Subject Term: GASTROINTESTINAL diseases; Subject Term: VIRUSES; Author-Supplied Keyword: Faeces; Author-Supplied Keyword: NLV; Author-Supplied Keyword: Norwalk-like virus; Author-Supplied Keyword: SRSV; Author-Supplied Keyword: Viral gastroenteritis; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S1386-6532(03)00170-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Foley, Steven L.
AU - Simjee, Shabbir
AU - Jianghong Meng
AU - White, David G.
AU - McDermott, Patrick F.
AU - Shaohua Zhao
T1 - Evaluation of Molecular Typing Methods for Escherichia coli O157:H7 Isolates from Cattle, Food, and Humans.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/04//
VL - 67
IS - 4
M3 - Article
SP - 651
EP - 657
SN - 0362028X
AB - Escherichia coli O157:H7, a Shiga toxin-producing E. coli, has been the causative agent of many cases of severe, often life-threatening foodhorne illness. Because of the importance of E. coli O157:H7 to public health, many molecular typing methods have been developed to determine its transmission routes and source of infection during epidemiological investigations. Pulsed-field gel electrophoresis (PFGE) is currently used by public health organizations to track infections of E. coli O157:H7 and other foodborne pathogens. In this study, we compared the ability of PFGE, multilocus sequence typing (MLST), and repetitive-element PCR (Rep-PCR) to distinguish among 92 E. coli O157:H7 isolates from cattle, food, and infected humans. Several virulence genes, including the intimin gene (eaeA), the hemolysin gene (hlyA), and the H7 fimbrial gene (fliC), and a housekeeping gene for β-glucuronidase (uidA) were included in MLST Rep-PCR reactions were performed using a commercially available typing kit (Bacterial Barcodes Inc., Houston, Tex.) with the provided Uptime-RI primer set. Results of the study indicated that PFGE provided the most discrimination among the techniques, identifying 72 distinct PFGE profiles for the isolates; Rep-PCR elucidated 14 different profiles, whereas MLST generated five profiles. Additionally, there did not appear to be any correlation among the typing methods examined in this study. Therefore, to date, PFGE remains the technique of choice for molecular subtyping of E. coli O157:H7. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Escherichia coli O157:H7
KW - Escherichia coli diseases
KW - Pulsed-field gel electrophoresis
KW - Bacteriophage typing
KW - Bacterial BarCodes Inc.
N1 - Accession Number: 12999398; Foley, Steven L. 1; Simjee, Shabbir 2; Jianghong Meng 3; White, David G. 2; McDermott, Patrick F. 2; Shaohua Zhao 2; Email Address: szhao@cvm.fda.gov; Affiliations: 1: Department of Biology, University of Central Arkansas, Conway, Arkansas; 2: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland; 3: Department of Nutrition and Food Science, University of Maryland, USA; Issue Info: Apr2004, Vol. 67 Issue 4, p651; Thesaurus Term: Foodborne diseases; Subject Term: Escherichia coli O157:H7; Subject Term: Escherichia coli diseases; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Bacteriophage typing ; Company/Entity: Bacterial BarCodes Inc.; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - White Jr., K. L.
AU - Germolec, D. R.
AU - Musgrove, D. L.
AU - Delclos, K. B.
AU - Newbold, R. R.
AU - Weis, C.
AU - Guo, T. L.
T1 - Vinclozolin Modulates Splenic Natural Killer Cell Activity, Antibody-Forming Cell Response and Phenotypic Marker Expression in Sprague Dawley Rats: A Two-Generation Feeding Study.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2004/04//
VL - 1
IS - 2
M3 - Article
SP - 113
EP - 121
PB - Taylor & Francis Ltd
SN - 1547691X
AB - The potential effects of the fungicide vinclozolin (VCZ) on the immune system were evaluated in F0 (dams) and F1 generations of Sprague Dawley rats exposed to a soy-free diet containing VCZ at 10, 150 and 750 ppm. In dams, exposure to VCZ at the highest concentration from gestation day 7 to postpartum day 51 (65 days total exposure) produced a significant increase in the numbers of splenocytes, B cells, T cells, helper T cells and cytotoxic T cells and a decrease in the percentage of NK cells. In F1 males, exposure to VCZ gestationally, lactationally and through feed from postnatal day 22 to 64 (78 days total exposure) produced no effect on spleen or thymus weights or splenocyte subsets. However, increases in the spleen IgM antibody-forming cell response to sheep red blood cells (150 and 750 ppm) and the activity of NK cells (150 ppm) were observed. In F1 females, exposure to VCZ produced a decrease in the activity of NK cells in all the treatment groups. Although decreases in the number of cytotoxic T cells (150 ppm) and the percentages of NK cells (10 ppm) and cytotoxic T cells (150 ppm) were also observed, the lack of a dose-related response suggested that these findings might not be biologically meaningful. In conclusion, these results demonstrate that exposure to VCZ at the concentrations tested modulates the immune responses in Sprague Dawley rats. Furthermore, the differential effect of VCZ in F1 male and female rats is consistent with the reported anti-androgenic properties of VCZ. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vinclozolin
KW - Killer cells
KW - Immune system
KW - Cells
KW - Rats as laboratory animals
KW - antibody-forming cell responses
KW - Antibody-forming Cell Responses.
KW - developmental immunotoxicity
KW - NK cell activity
KW - vinclozolin
N1 - Accession Number: 15314096; White Jr., K. L. 1; Germolec, D. R. 2; Musgrove, D. L. 1; Delclos, K. B. 3; Newbold, R. R. 2; Weis, C. 3; Guo, T. L. 1; Email Address: tlguo@hsc.vcu.edu; Affiliations: 1: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; 2: Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC, USA; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA; Issue Info: Apr2004, Vol. 1 Issue 2, p113; Subject Term: Vinclozolin; Subject Term: Killer cells; Subject Term: Immune system; Subject Term: Cells; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: antibody-forming cell responses; Author-Supplied Keyword: Antibody-forming Cell Responses.; Author-Supplied Keyword: developmental immunotoxicity; Author-Supplied Keyword: NK cell activity; Author-Supplied Keyword: vinclozolin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/15476910490518893
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - House, Robert V.
AU - Hastings, Kenneth L.
T1 - Multidimensional Immunomodulation.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2004/04//
VL - 1
IS - 2
M3 - Article
SP - 123
EP - 129
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Discusses the concept of immunotoxicology. Condition of increased immune function leading to either autoimmunity or hypersensitivity; Models of immunotoxicology; Definition of hypersensitivity.
KW - Toxicology
KW - Immunity
KW - Allergy
KW - Immunotoxicology
KW - Autoimmunity
N1 - Accession Number: 15314097; House, Robert V. 1; Hastings, Kenneth L. 2; Affiliations: 1: DynPort Vaccine Company LLC, Frederick, Maryland, USA; 2: Office of New Drugs, Center for Drug Evaluation and Research, United States Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Apr2004, Vol. 1 Issue 2, p123; Thesaurus Term: Toxicology; Thesaurus Term: Immunity; Thesaurus Term: Allergy; Subject Term: Immunotoxicology; Subject Term: Autoimmunity; Number of Pages: 7p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1080/15476910490503646
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106776006
T1 - Comparison of capillary earlobe and venous blood monitoring for occupational lead surveillance.
AU - Taylor L
AU - Jones RL
AU - Ashley K
AU - Deddens JA
AU - Kwan L
Y1 - 2004/04//2004 Apr
N1 - Accession Number: 106776006. Language: English. Entry Date: 20040910. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0375375.
KW - Occupational Exposure -- Prevention and Control
KW - Blood Specimen Collection -- Methods
KW - Lead -- Blood
KW - Lead Poisoning -- Prevention and Control
KW - Ear, External -- Blood Supply
KW - Capillaries
KW - Veins
KW - Lead Poisoning -- Diagnosis
KW - Occupational Health
KW - Hemoglobins
KW - Skin Care
KW - Comparative Studies
KW - Descriptive Statistics
KW - Linear Regression
KW - Adult
KW - Middle Age
KW - Female
KW - Male
KW - Human
SP - 217
EP - 224
JO - Journal of Laboratory & Clinical Medicine
JF - Journal of Laboratory & Clinical Medicine
JA - J LAB CLIN MED
VL - 143
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - Biological monitoring for occupational lead exposure involves routine venous blood draws from exposed employees. This uncomfortable procedure normally yields more blood than what is needed for analysis. Capillary blood sampling is less invasive but introduces the possibility of surface contamination. The objective of this study was to compare venous and capillary (earlobe) blood lead samples obtained from occupationally exposed individuals. Phlebotomists trained specifically in the collection of blood samples for lead determination collected 2 venous blood samples and 2 capillary earlobe samples from each participating employee. Before the capillary draw, the employee's earlobe was cleansed with an alcohol wipe in an effort to remove potential lead contamination. A second alcohol wipe was then used to sanitize the lancing area and was retained for lead analysis. Both the venous and capillary samples were subsequently analyzed with the use of graphite furnace atomic absorption spectrometry (GFAAS). GFAAS of venous blood specimens was considered the reference method of sampling and analysis. We collected and analyzed 126 paired earlobe and venous samples. Earlobe sampling was preferred to venous sampling by 54% of the employees surveyed. The mean difference between the capillary and venous results was 38.8 +/- 48.1 microg/dL. Lead concentrations in earlobe blood were more than twice those found in venous samples in more than half of the samples (64 of 126). Despite simple cleansing with an alcohol wipe and no visible skin contamination, 94% of the wipe samples from earlobes contained more than 1 microg of lead. Even low concentrations of contamination can significantly alter the concentration of lead in the blood; for example, sample contamination of 0.3 microg lead in a 200-microL blood sample would yield an increase of 150 microg/dL in the measured lead concentration. The findings of this study suggest that until satisfactory skin cleansing and decontamination techniques are identified and evaluated, earlobe sampling should be avoided in the surveillance of occupational blood lead levels.
SN - 0022-2143
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226-1998; LTaylor@cdc.gov
U2 - PMID: 15085080.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106779651
T1 - Discrimination and occupational mental health.
AU - Roberts RK
AU - Swanson NG
AU - Murphy LR
Y1 - 2004/04//
N1 - Accession Number: 106779651. Language: English. Entry Date: 20040924. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9212352.
KW - Mental Health Services
KW - Occupational Health
KW - Racism
KW - Adult
KW - Analysis of Covariance
KW - Chi Square Test
KW - Descriptive Statistics
KW - Discrimination
KW - Female
KW - Health Status Indicators
KW - Interviews
KW - Job Satisfaction
KW - Male
KW - Middle Age
KW - Minority Groups
KW - Occupations and Professions
KW - P-Value
KW - Race Factors
KW - Social Attitudes
KW - Stress, Occupational
KW - Surveys
KW - United States
KW - Work Environment
KW - Human
SP - 129
EP - 142
JO - Journal of Mental Health
JF - Journal of Mental Health
JA - J MENT HEALTH
VL - 13
IS - 2
CY - Oxfordshire,
PB - Routledge
AB - Background: Racial and ethnic discrimination has been shown to occur in work organizations, yet little is known about the relationship of this stressor to occupational mental health.Aims: This paper explores the degree to which racial and ethnic groups may be subjected to discrimination at work and examines associations between discrimination and mental health indicators.Methods: In a national study, 1728 American workers were interviewed about aspects of their jobs, their exposure to racial and ethnic discrimination at work, and dimensions of their mental health.Results: American minorities reported perceptions of discrimination at work at greater frequencies than White Americans, and findings suggested some indication of institutional discrimination against minorities. Further, White, Black, and Hispanic-Americans, who reported that they had been discriminated against, were found to have poorer mental health outcomes than their same-race counterparts, who did not acknowledge being discriminated against.Conclusions: These findings may be used to inform the development of occupational stress and health models that are more cross-culturally applicable.
SN - 0963-8237
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, C-24, Cincinnati, OH 45226; rsr3@cdc.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Coffey, Christopher C.
AU - Lawrence, Robert B.
AU - Campbell, Donald L.
AU - Zhuang, Ziqing
AU - Calvert, Catherine A.
AU - Jensen, Paul A.
T1 - Fitting Characteristics of Eighteen N95 Filtering-Facepiece Respirators.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/04//
VL - 1
IS - 4
M3 - Article
SP - 262
EP - 271
PB - Taylor & Francis Ltd
SN - 15459624
AB - Four performance measures were used to evaluate the fitting characteristics of 18 models of N95 filtering-facepiece respirators: (1) the 5th percentile simulated workplace protection factor (SWPF) value, (2) the shift average SWPF value, (3) the h-value, and (4) the assignment error. The effect of fit-testing on the level of protection provided by the respirators was also evaluated. The respirators were tested on a panel of 25 subjects with various face sizes. Simulated workplace protection factor values, determined from six total penetration (face-seal leakage plus filter penetration) tests with re-donning between each test, were used to indicate respirator performance. Five fit-tests were used: Bitrex™, saccharin, generated aerosol corrected for filter penetration, PortaCount® Plus corrected for filter penetration, and the PortaCount Plus with the N95-Companion™ accessory. Without fit-testing, the 5th percentile SWPF for all models combined was 2.9 with individual model values ranging from 1.3 to 48.0. Passing a fit-test generally resulted in an increase in protection. In addition, the h-value of each respirator was computed. The h-value has been determined to be the population fraction of individuals who will obtain an adequate level of protection (i.e., SWPF >10, which is the expected level of protection for half-facepiece respirators) when a respirator is selected and donned (including a user seal check) in accordance with the manufacturer's instructions without fit-testing. The h-value for all models combined was 0.74 (i.e., 74% of all donnings resulted in an adequate level of protection), with individual model h-values ranging from 0.31 to 0.99. Only three models had h-values above 0.95. Higher SWPF values were achieved by excluding SWPF values determined for test subject respirator combinations that failed a fit-test. The improvement was greatest for respirator models with lower h-values. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Artificial respiration
KW - Breathing apparatus
KW - Gas masks
KW - Work environment
KW - Industrial engineering
KW - Accident prevention
N1 - Accession Number: 12828599; Coffey, Christopher C. 1; Email Address: ecoffey@edc.gov; Lawrence, Robert B. 1; Campbell, Donald L. 1; Zhuang, Ziqing 2; Calvert, Catherine A. 1; Jensen, Paul A. 1; Affiliations: 1: Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia.; 2: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania.; Issue Info: Apr2004, Vol. 1 Issue 4, p262; Thesaurus Term: Industrial safety; Thesaurus Term: Artificial respiration; Subject Term: Breathing apparatus; Subject Term: Gas masks; Subject Term: Work environment; Subject Term: Industrial engineering; Subject Term: Accident prevention; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15459620490433799
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DB - eih
ER -
TY - JOUR
ID - 106681021
T1 - Fitting characteristics of eighteen N95 filtering-facepiece respirators.
AU - Coffey CC
AU - Lawrence RB
AU - Campbell DL
AU - Zhuang Z
AU - Calvert CA
AU - Jensen PA
Y1 - 2004/04//
N1 - Accession Number: 106681021. Language: English. Entry Date: 20040625. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Note: For CE see Suppl pages D47-8. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Evaluation
KW - Respiratory Protective Devices -- Standards
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Evaluation Research
KW - National Institute for Occupational Safety and Health -- Standards
KW - Saccharin
KW - United States Occupational Safety and Health Administration -- Standards
KW - Human
SP - 262
EP - 271
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Four performance measures were used to evaluate the fitting characteristics of 18 models of N95 filtering-facepiece respirators: (1) the 5th percentile simulated workplace protection factor (SWPF) value, (2) the shift average SWPF value, (3) the h-value, and (4) the assignment error. The effect of fit-testing on the level of protection provided by the respirators was also evaluated. The respirators were tested on a panel of 25 subjects with various face sizes. Simulated workplace protection factor values, determined from six total penetration (face-seal leakage plus filter penetration) tests with re-donning between each test, were used to indicate respirator performance. Five fit-tests were used: BitrexT, saccharin, generated aerosol corrected for filter penetration, PortaCountr Plus corrected for filter penetration, and the PortaCount Plus with the N95-CompanionT accessory. Without fit-testing, the 5th percentile SWPF for all models combined was 2.9 with individual model values ranging from 1.3 to 48.0. Passing a fit-test generally resulted in an increase in protection. In addition, the h-value of each respirator was computed. The h-value has been determined to be the population fraction of individuals who will obtain an adequate level of protection (i.e., SWPF =10, which is the expected level of protection for half-facepiece respirators) when a respirator is selected and donned (including a user seal check) in accordance with the manufacturer's instructions without fit-testing. The h-value for all models combined was 0.74 (i.e., 74% of all donnings resulted in an adequate level of protection), with individual model h-values ranging from 0.31 to 0.99. Only three models had h-values above 0.95. Higher SWPF values were achieved by excluding SWPF values determined for test subject/respirator combinations that failed a fit-test. The improvement was greatest for respirator models with lower h-values. Using the concepts of shift average and assignment error to measure respirator performance yielded similar results. The highest level of protection was provided by passing a fit-test with a respirator having good fitting characteristics.
SN - 1545-9624
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888; ccoffey@cdc.gov
U2 - PMID: 15204866.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shopland, Donald R.
AU - Anderson, Christy M.
AU - Burns, David M.
AU - Gerlach, Karen K.
T1 - Disparities in Smoke-Free Workplace Policies Among Food Service Workers.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2004/04//
VL - 46
IS - 4
M3 - Article
SP - 347
EP - 356
SN - 10762752
AB - Information is lacking on which groups of workers are protected from job-related environmental tobacco smoke. Data from the Census Bureau's Current Population Survey are analyzed for trends in smoke-free workplace policies among 38 major occupations. Data are also analyzed to determine the degree of compliance with such policies. Although over three fourths of white collar workers are covered by smoke-free policies, including 90% of teachers, just 43% of the country's 6.6 million food preparation and service occupations workers benefit from this level of protection. Compliance with workplace restrictions is not a significant human resources issue because only 3.8% of workers reported that someone violated a smoke-free policy in 1999, down from 4.9% in 1996. Protection for workers is increasing, but those in food preparation and service occupations are significantly less protected than others. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOBACCO smoke pollution
KW - INDOOR air pollution
KW - PASSIVE smoking
KW - INDUSTRIAL workers
KW - SURVEYS
KW - INDUSTRIAL hygiene
KW - ENVIRONMENTAL health
N1 - Accession Number: 13049658; Shopland, Donald R. 1,2; Email Address: reedonald@aol.com Anderson, Christy M. 2 Burns, David M. 2 Gerlach, Karen K. 3; Affiliation: 1: U.S. Public Health Service, Georgia 2: University of California at San Diego, California 3: The Robert Wood Johnson Foundation, New Jersey; Source Info: Apr2004, Vol. 46 Issue 4, p347; Subject Term: TOBACCO smoke pollution; Subject Term: INDOOR air pollution; Subject Term: PASSIVE smoking; Subject Term: INDUSTRIAL workers; Subject Term: SURVEYS; Subject Term: INDUSTRIAL hygiene; Subject Term: ENVIRONMENTAL health; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1097/01.jom.0000121129.78510
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13049658&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106607012
T1 - Disparities in smoke-free workplace policies among food service workers.
AU - Shopland DR
AU - Anderson CM
AU - Burns DM
AU - Gerlach KK
Y1 - 2004/04//
N1 - Accession Number: 106607012. Language: English. Entry Date: 20050415. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: American Legacy Foundation, Washington, DC and the Flight Attendant Medical Research Foundation, Miami, FL. NLM UID: 9504688.
KW - Food Services -- Evaluation
KW - Occupational Exposure -- Prevention and Control
KW - Organizational Policies -- Evaluation
KW - Smoking -- Prevention and Control
KW - Confidence Intervals
KW - Cooperative Behavior
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Interviews
KW - Male
KW - P-Value
KW - Sex Factors
KW - Human
SP - 347
EP - 356
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 46
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Information is lacking on which groups of workers are protected from job-related environmental tobacco smoke. Data from the Census Bureau's Current Population Survey are analyzed for trends in smoke-free workplace policies among 38 major occupations. Data are also analyzed to determine the degree of compliance with such policies. Although over three fourths of white collar workers are covered by smoke-free policies, including 90% of teachers, just 43% of the country's 6.6 million food preparation and service occupations workers benefit from this level of protection. Compliance with workplace restrictions is not a significant human resources issue because only 3.8% of workers reported that someone violated a smoke-free policy in 1999, down from 4.9% in 1996. Protection for workers is increasing, but those in food preparation and service occupations are significantly less protected than others.
SN - 1076-2752
AD - U.S. Public Health Service, Ringgold, GA; reedonald@aol.com
U2 - PMID: 15076653.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Idowu, Olutosin R.
AU - Peggins, James O.
T1 - Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high-performance liquid chromatography with fluorescence detection
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2004/04//
VL - 35
IS - 1
M3 - Article
SP - 143
SN - 07317085
AB - A rapid and simple procedure for determination of enrofloxacin and ciprofloxacin in bovine milk and plasma is described.Protein precipitation from both milk and plasma samples was achieved by addition of acetonitrile and phosphoric acid. Acetonitrile was removed with methylene chloride, leaving enrofloxacin and ciprofloxacin in the acidic aqueous extract. The aqueous extract was analyzed by high-performance liquid chromatography (HPLC) with fluorescence detection. The limit of quantitation (LOQ) for enrofloxacin and ciprofloxacin in milk was found to be 2 ng/ml. LOQ for enrofloxacin and ciprofloxacin in plasma was found to be 1 ng/ml. Linear calibration curves were obtained with correlation coefficient (r2) ≥0.99. Analysis of quality control (QC) samples gave results within ±10% of the nominal values. Inter-assay precision for the analysis of milk QC samples were in the ranges: 4.63–12.49% (for enrofloxacin) and 4.67–9.86% (for ciprofloxacin). Inter-assay precision for the analysis of plasma QC samples were in the ranges: 6.60–17.31% (for enrofloxacin) and 6.14–13.87% (for ciprofloxacin).Intra-assay precision for the analysis of milk QC samples were in the following ranges: 3.65–7.21% (for enrofloxacin) and 1.58–14.28% (for ciprofloxacin). Intra-assay precision for the analysis of plasma QC samples were in the following ranges: 2.17–16.95% (for enrofloxacin) and 3.31–16.31% (for ciprofloxacin).The effectiveness of protein precipitants other than phosphoric acid was investigated. The method described has been applied to a study of the pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CIPROFLOXACIN
KW - QUINOLONE antibacterial agents
KW - BLOOD plasma
KW - LIQUID chromatography
KW - Bovine milk
KW - Bovine plasma
KW - Ciprofloxacin
KW - Enrofloxacin
KW - HPLC
N1 - Accession Number: 12503040; Idowu, Olutosin R.; Email Address: oidowu@cvm.fda.gov Peggins, James O. 1; Affiliation: 1: US Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Apr2004, Vol. 35 Issue 1, p143; Subject Term: CIPROFLOXACIN; Subject Term: QUINOLONE antibacterial agents; Subject Term: BLOOD plasma; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Bovine milk; Author-Supplied Keyword: Bovine plasma; Author-Supplied Keyword: Ciprofloxacin; Author-Supplied Keyword: Enrofloxacin; Author-Supplied Keyword: HPLC; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jpba.2004.01.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Yasnoff, WA;
AU - Humphreys, BL;
AU - Overhage, JM;
AU - Detmer, DE;
AU - Fanning, JP;
AU - et al;
T1 - A consensus action agenda for achieving the national health information infrastructure
CT - A consensus action agenda for achieving the national health information infrastructure
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
Y1 - 2004/04/01/
VL - 11
IS - Apr
SP - 332
EP - 338
SN - 10675027
AD - US Dept HHS, Off Assistant Secretary Planning & Evaluat, Room 440D,Hubert H Humphrey Bldg,220 Independence, Washington, DC 20201, USA william.yasnoff@hhs.gov
N1 - Accession Number: 41-17442; Language: English; References: 23; Journal Coden: JAMIA; Section Heading: Information Processing and Literature; Sociology, Economics and Ethics
N2 - Background: Improving the safety, quality, and efficiency of health care will require immediate and ubiquitous access to complete patient information and decision support provided through a National Health Information Infrastructure (NHII). Methods: To help define the action steps needed to achieve an NHII, the U.S. Department of Health and Human Services sponsored a national consensus conference in July 2003. Results: Attendees favored a public-private coordination group to guide NHII activities, provide education, share resources, and monitor relevant metrics to mark progress. They identified financial incentives, health information standards, and overcoming a few important legal obstacles as key NHII enablers. Community and regional implementation projects, including consumer access to a personal health record, were seen as necessary to demonstrate comprehensive functional systems that can serve as models for the entire nation. Finally, the participants identified the need for increased funding for research on the impact of health information technology on patient safety and quality of care. Individuals, organizations, and federal agencies are using these consensus recommendations to guide NHII efforts.
KW - Computers--patient information;
KW - Decision making--patient information;
KW - Standards--patient information;
KW - Economics--patient information;
KW - Regulations--patient information;
KW - Patient information--computers;
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DP - EBSCOhost
DB - ipa
ER -
TY - GEN
AU - Hubbard, William K.
T1 - High Prescription Drug Prices and the Influence of the Food and Drug Administration.
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
Y1 - 2004/04//
VL - 79
IS - 4
M3 - Letter
SP - 569
EP - 570
SN - 00256196
AB - Presents a letter to the editor to respond to the comment on the role of the U.S. Food and Drug Administration in the reduction of high prescription drug prices.
KW - LETTERS to the editor
KW - DRUGS -- Prices
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 12736849; Hubbard, William K. 1; Affiliation: 1: US Food and Drug Administration; Source Info: Apr2004, Vol. 79 Issue 4, p569; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Prices; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106603954
T1 - Predicting EuroQoL EQ-5D preference scores from the SF-12 health survey in a nationally representative sample.
AU - Lawrence WF
AU - Fleishman JA
Y1 - 2004/04//Mar/Apr2004
N1 - Accession Number: 106603954. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: EuroQol EQ-5D; Short Form 12 Health Survey (SF-12). Grant Information: Agency for Healthcare Research and Quality. NLM UID: 8109073.
KW - Health Status
KW - Quality of Life -- Evaluation
KW - Adult
KW - Aged
KW - Analysis of Covariance
KW - Analysis of Variance
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Regression
KW - Research Instruments
KW - Funding Source
KW - Human
SP - 160
EP - 169
JO - Medical Decision Making
JF - Medical Decision Making
JA - MED DECIS MAKING
VL - 24
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - PURPOSE: To predict the EuroQoL EQ-5D utility index from the SF-12 Health Survey for a US national sample of adults. METHODS: The authors used the 2000 Medical Expenditure Panel Survey to examine the relationship between instruments. Linear regression was used to predict EQ-5D scores from Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the SF-12. A prediction model was derived in one half of the sample and validated in the other half. RESULTS: Complete responses to both measures were available for 14,580 adults; 7313 (50.2%) surveys were used for the derivation set. The 2-variable model predicted 61% of the variance in EQ-5D scores and provided reasonable ability to predict mean EQ-5D scores from mean PCS and MCS scores. Confidence intervals are dependent on sample size and variance of PCS and MCS scores. CONCLUSIONS: EQ-5D scores can be reasonably predicted from the SF-12. This model allows researchers to estimate utility data for use in decision and cost-utility analyses.
SN - 0272-989X
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Suite 300, 540 Gaither Rd, Rockville, MD 20850; william.lawrence@ahrq.hhs.gov
U2 - PMID: 15090102.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106610620
T1 - Counterfeit drugs.
AU - Rudolf PM
AU - Bernstein IBG
Y1 - 2004/04//4/1/2004
N1 - Accession Number: 106610620. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Counterfeit Drugs -- Legislation and Jurisprudence -- United States
KW - Fraud -- Legislation and Jurisprudence -- United States
KW - Sellers and Selling -- Legislation and Jurisprudence -- United States
KW - Fraud -- Prevention and Control
KW - United States
KW - United States Food and Drug Administration
SP - 1384
EP - 1386
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 350
IS - 14
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Food and Drug Administration, Rockville, MD
U2 - PMID: 15070787.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Marders, Julia
T1 - PCA by proxy: Too much of a good thing.
JO - Nursing
JF - Nursing
Y1 - 2004/04//
VL - 34
IS - 4
M3 - Article
SP - 24
EP - 24
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - Provides device safety tips on patient-controlled analgesia (PCA) by proxy. Importance of patient's participation to maintain safety; Need to develop and follow guidelines for using PCA pumps; Notification of nurse if the patients seems overly sleepy.
KW - PATIENT-controlled analgesia
KW - PATIENTS
KW - SAFETY
KW - PUMPING machinery
KW - NURSES
KW - SELF-Made (Book)
N1 - Accession Number: 12596393; Marders, Julia 1; Affiliation: 1: Center for Devices and Radiological Health of the Food and Drug Administration in Rockville; Source Info: Apr2004, Vol. 34 Issue 4, p24; Subject Term: PATIENT-controlled analgesia; Subject Term: PATIENTS; Subject Term: SAFETY; Subject Term: PUMPING machinery; Subject Term: NURSES; Reviews & Products: SELF-Made (Book); NAICS/Industry Codes: 333910 Pump and compressor manufacturing; NAICS/Industry Codes: 333911 Pump and Pumping Equipment Manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106728109
T1 - Device safety. PCA by proxy: too much of a good thing.
AU - Marders J
Y1 - 2004/04//
N1 - Accession Number: 106728109. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety
KW - Patient Safety
KW - Patient-Controlled Analgesia -- Adverse Effects
KW - Patient-Controlled Analgesia -- Nursing
SP - 24
EP - 24
JO - Nursing
JF - Nursing
JA - NURSING
VL - 34
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 15247654.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Haber, Penina
AU - Chen, Robert T.
AU - Zanardi, Lynn R.
AU - Mootrey, Gina T.
AU - English, Roseanne
AU - Braun, M. Miles
AU - Iskander, John
AU - Pool, Vitali
AU - Campbell, Scott
AU - Weigong Zhou, Scott
AU - Miller, Elaine
AU - Rashidee, Ali
AU - Kohl, Katrin
AU - Holmes, Sharon
AU - Pless, Robert
AU - Ball, Robert
AU - Wise, Robert
AU - Burwen, Dale
AU - Varricchio, Fred
AU - Davis, David
T1 - An Analysis of Rotavirus Vaccine Reports to the Vaccine Adverse Event Reporting System: More Than Intussusception Alone?
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/04//
VL - 113
IS - 4
M3 - Article
SP - e353
EP - e359
PB - American Academy of Pediatrics
SN - 00314005
AB - Background. The rhesus-human rotavirus reassortant-tetravalent vaccine (RRV-TV) was licensed on August, 31, 1998, and subsequently recommended for routine infant immunizations in the United States. After ∼1 million doses had been administered, an increase in acute risk of intussusception in vaccinees led to the suspension of the use of RRV-TV and its withdrawal from the market. These postmarketing safety studies focused on a single adverse event (intussusception) and, to minimize the risk of a false-positive finding, accepted only cases that met a strict case definition. Safer rotavirus vaccines are needed to prevent the substantial global morbidity and mortality caused by rotavirus infections; their development and future use may benefit from a better understanding of the postmarketing safety profile of RRV-TV beyond intussusception. Objective. To characterize more completely the post-marketing surveillance safety profile of RRV-TV more completely by review and analysis of Vaccine Adverse Event Reporting System (VAERS) case reports to better understand 1) whether severe adverse events other than intussusception may have occurred after RRV-TV and 2) the likely scope of gastrointestinal illnesses, of which the previously identified, highly specific intussusception cases may account for just a fraction. Setting and Participants. Infants vaccinated with RRV-TV and other vaccines in the United States and for whom a report was submitted to VAERS during September 1, 1998, to December 31, 1999. Methodology. To detect adverse events of interest other than intussusception, we used proportional morbidity analysis to compare the adverse event profile of VAERS reports among infants who received routine vaccines including RRV-TV (after excluding confirmed and suspected intussusception reports) with infants who received identical vaccine combinations but without RRV-TV. Next, to better capture all described diagnoses, signs, and symptoms associated with the suspected... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases -- Vaccination
KW - ROTAVIRUS diseases
KW - IMMUNIZATION of infants
KW - PEDIATRICS -- Immunological aspects
KW - INTUSSUSCEPTION in children
KW - postmarketing surveillance
KW - rotavirus vaccine
KW - Vaccine Adverse Event Reporting System
KW - vaccine safety
KW - VAERS
N1 - Accession Number: 12517368; Haber, Penina 1; Email Address: phaber@cdc.gov Chen, Robert T. 1 Zanardi, Lynn R. 1 Mootrey, Gina T. 1 English, Roseanne 1 Braun, M. Miles 2 Iskander, John 3 Pool, Vitali 3 Campbell, Scott 3 Weigong Zhou, Scott 3 Miller, Elaine 3 Rashidee, Ali 3 Kohl, Katrin 3 Holmes, Sharon 3 Pless, Robert 3 Ball, Robert 3 Wise, Robert 3 Burwen, Dale 3 Varricchio, Fred 3 Davis, David 3; Affiliation: 1: National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Division of Epidemiology, Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, Maryland 3: Member, VAERS; Source Info: Apr2004, Vol. 113 Issue 4, pe353; Subject Term: ROTAVIRUS diseases -- Vaccination; Subject Term: ROTAVIRUS diseases; Subject Term: IMMUNIZATION of infants; Subject Term: PEDIATRICS -- Immunological aspects; Subject Term: INTUSSUSCEPTION in children; Author-Supplied Keyword: postmarketing surveillance; Author-Supplied Keyword: rotavirus vaccine; Author-Supplied Keyword: Vaccine Adverse Event Reporting System; Author-Supplied Keyword: vaccine safety; Author-Supplied Keyword: VAERS; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Willy, Mary E.
AU - Li, Zili
T1 - What is prescription labeling communicating to doctors about hepatotoxic drugs? A study of FDA approved product labeling.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2004/04//
VL - 13
IS - 4
M3 - Article
SP - 201
EP - 206
SN - 10538569
AB - Purpose The objective of this study was to evaluate the informativeness and consistency of product labeling of hepatotoxic drugs marketed in the United States. Methods We searched the Physicians' Desk Reference-2000 for prescription drugs with hepatic failure and/or hepatic necrosis listed in the labeling. We used a six-item checklist to evaluate the 'informativeness' and consistency of the labeling content. An informativeness score equaled the proportion of checklist items present in each drug's labeling. Results Ninety-five prescription drugs were included in the study. Eleven (12%) of the drugs had information related to hepatic failure in a Black Boxed Warning, 52 (54%) in the Warnings section and 32 (34%) in the Adverse Reactions section of the label. The mean informativeness score was 35%; the score was significantly higher, 61%, when the risk was perceived to be high. The informativeness of labeling was not affected by the time of the labeling, but differed across the Center for Drug Evaluation and Research (CDER) Review Division responsible for the labeling. Conclusions The information provided in labeling is variable and affected by many factors, including the perceived level of risk and review division strategy. Product labeling may benefit from current FDA initiatives to improve the consistency of risk-related labeling. Published in 2003 by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64710019; Willy, Mary E. 1; Li, Zili 1; Affiliations: 1: Office of Drug Safety, Food and Drug Administration, Rockville, MD, USA; Issue Info: Apr2004, Vol. 13 Issue 4, p201; Number of Pages: 6p; Document Type: Article
L3 - 10.1002/pds.856
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, Huizhong
AU - Wang, Rong-Fu
AU - Cerniglia, Carl E.
T1 - Molecular cloning, overexpression, purification, and characterization of an aerobic FMN-dependent azoreductase from Enterococcus faecalis
JO - Protein Expression & Purification
JF - Protein Expression & Purification
Y1 - 2004/04//
VL - 34
IS - 2
M3 - Article
SP - 302
SN - 10465928
AB - Azo dyes represent a major class of synthetic colorants that are ubiquitous in foods and consumer products. Enterococcus faecalis is a predominant member of the human gastrointestinal microflora. Strain ATCC 19433 grew in the presence of azo dyes and metabolized them to colorless products. A gene encoding a putative FMN-dependent aerobic azoreductase that shares 34% identity with azoreductase (AcpD) of Escherichia coli has been identified in this strain. The gene in E. faecalis, designated as azoA, encoded a protein of 208 amino acids with a calculated isoelectric point of 4.8. AzoA was heterologously overexpressed in E. coli with a strong band of 23 kDa on SDS–PAGE. The purified recombinant enzyme was a homodimer with a molecular weight of 43 kDa, probably containing one molecule of FMN per dimer. AzoA required FMN and NADH, but not NADPH, as a preferred electron donor for its activity. The apparent Km values for both NADH and 2-[4-(dimethylamino)phenylazo]benzoic acid (Methyl red) substrates were 0.14 and 0.024 mM, respectively. The apparent Vmax was 86.2 μM/min/mg protein. The enzyme was not only able to decolorize Methyl red, but was also able to convert sulfonated azo dyes Orange II, Amaranth, Ponceau BS, and Ponceau S. AzoA is the first aerobic azoreductase to be identified and characterized from human intestinal gram-positive bacteria. [Copyright &y& Elsevier]
AB - Copyright of Protein Expression & Purification is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - ENZYME activation
KW - ESCHERICHIA coli
KW - BACTERIA
KW - Aerobic azoreductase
KW - Azo dye
KW - Enterococcus faecalis
KW - Human intestinal microflora
N1 - Accession Number: 12383142; Chen, Huizhong; Email Address: HChen@nctr.fda.gov Wang, Rong-Fu 1 Cerniglia, Carl E. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA; Source Info: Apr2004, Vol. 34 Issue 2, p302; Subject Term: AMINO acids; Subject Term: ENZYME activation; Subject Term: ESCHERICHIA coli; Subject Term: BACTERIA; Author-Supplied Keyword: Aerobic azoreductase; Author-Supplied Keyword: Azo dye; Author-Supplied Keyword: Enterococcus faecalis; Author-Supplied Keyword: Human intestinal microflora; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.pep.2003.12.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12383142&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, K.
AU - Aalbers, M.
AU - Bannon, G.A.
AU - Bartels, M.
AU - Dearman, R.J.
AU - Esdaile, D.J.
AU - Fu, T.J.
AU - Glatt, C.M.
AU - Hadfield, N.
AU - Hatzos, C.
AU - Hefle, S.L.
AU - Heylings, J.R.
AU - Goodman, R.E.
AU - Henry, B.
AU - Herouet, C.
AU - Holsapple, M.
AU - Ladics, G.S.
AU - Landry, T.D.
AU - MacIntosh, S.C.
AU - Rice, E.A.
T1 - A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2004/04//
VL - 39
IS - 2
M3 - Article
SP - 87
SN - 02732300
AB - Rationale. Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that incorporates an evaluation of protein digestibility in pepsin. Currently, there is no standardized protocol to assess the digestibility of proteins using simulated gastric fluid. Potential variations in assay parameters include: pH, pepsin purity, pepsin to target protein ratio, target protein purity, and method of detection. The objective was to assess the digestibility of a common set of proteins in nine independent laboratories to determine the reproducibility of the assay when performed using a common protocol.Methods. A single lot of each test protein and pepsin was obtained and distributed to each laboratory. The test proteins consisted of Ara h 2 (a peanut conglutin-like protein), β-lactoglobulin, bovine serum albumin, concanavalin A, horseradish peroxidase, ovalbumin, ovomucoid, phosphinothricin acetyltransferase, ribulose diphosphate carboxylase, and soybean trypsin inhibitor. A ratio of 10 U of pepsin activity/μg test protein was selected for all tests (3:1 pepsin to protein, w:w). Digestions were performed at pH 1.2 and 2.0, with sampling at 0.5, 2, 5, 10, 20, 30, and 60 min. Protein digestibility was assessed from stained gels following SDS–PAGE of digestion samples and controls.Results. Results were relatively consistent across laboratories for the full-length proteins. The identification of proteolytic fragments was less consistent, being affected by different fixation and staining methods. Overall, assay pH did not influence the time to disappearance of the full-length protein or protein fragments, however, results across laboratories were more consistent at pH 1.2 (91% agreement) than pH 2.0 (77%).Conclusions. These data demonstrate that this common protocol for evaluating the in vitro digestibility of proteins is reproducible and yields consistent results when performed using the same proteins at different laboratories. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Genetically modified foods
KW - Gastrointestinal system
KW - Proteins
KW - Biotechnology
KW - Digestive stability
KW - Pepsinolysis
KW - Protein allergenicity
N1 - Accession Number: 12578199; Thomas, K. 1; Email Address: kthomas@ilsi.org; Aalbers, M. 2; Bannon, G.A. 3; Bartels, M. 4; Dearman, R.J. 5; Esdaile, D.J. 6; Fu, T.J. 7; Glatt, C.M. 8; Hadfield, N. 5; Hatzos, C. 7; Hefle, S.L. 9; Heylings, J.R. 5; Goodman, R.E. 3; Henry, B. 10; Herouet, C. 6; Holsapple, M. 1; Ladics, G.S. 8; Landry, T.D. 4; MacIntosh, S.C. 10; Rice, E.A. 3; Affiliations: 1: ILSI Health and Environmental Sciences Institute, Washington, DC, USA; 2: Sanquin Research, Amsterdam, Netherlands; 3: Monsanto Co., St.Louis, MO, USA; 4: The Dow Chemical Co., Midland, MI, USA; 5: Syngenta Central Toxicology Laboratory, Alderley Park, UK; 6: Bayer CropScience, Sophia Antipolis, France; 7: US Food and Drug Administration National Center for Food Safety and Technology, Summit Argo, IL, USA; 8: DuPont Co., Newark, DE,USA; 9: University of Nebraska, Lincoln, NE, USA; 10: Bayer CropScience, Research Triangle Park, NC, USA; Issue Info: Apr2004, Vol. 39 Issue 2, p87; Thesaurus Term: Allergens; Thesaurus Term: Genetically modified foods; Subject Term: Gastrointestinal system; Subject Term: Proteins; Author-Supplied Keyword: Biotechnology; Author-Supplied Keyword: Digestive stability; Author-Supplied Keyword: Pepsinolysis; Author-Supplied Keyword: Protein allergenicity; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.yrtph.2003.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12578199&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Whetten, Kathryn
AU - Reif, Susan
AU - Lowe, Kristin
AU - Eldred, Lois
T1 - Gender Differences in Knowledge and Perceptions of HIV Resources Among Individuals Living with HIV in the Southeast.
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 2004/04//
VL - 97
IS - 4
M3 - Article
SP - 342
EP - 349
PB - Lippincott Williams & Wilkins
SN - 15418243
AB - Objectives: Ancillary services have been associated with beneficial health utilization outcomes among individuals infected with the human immunodeficiency virus (HIV), including greater retention in medical care and greater likelihood of antiretroviral use. Our primary objectives were to examine gender differences in barriers to ancillary services among people living with HIV in the Southeastern United States. Methods: Survey and chart abstraction data were collected from six tertiary infectious diseases clinics in the Southeast. Using multivariate analyses, we examined the relationship between gender and 1) knowledge of how to access HIV and acquired immunodeficiency syndrome (AIDS) resource information and 2) opinions about the helpfulness of local services for people with HIV/AIDS. Results: Women were less knowledgeable about HIV/AIDS resources and rated local services less favorably than men. Middle-aged and older African-American women rated local services as less helpful than other survey participants did. Conclusions: These findings indicate a need for outreach services that are designed to address the specific needs of older African-American women, and women in general.
KW - HIV (Viruses)
KW - MEDICAL care
KW - ANTIRETROVIRAL agents
KW - AIDS (Disease)
KW - SEX differences (Biology)
KW - UNITED States
KW - acquired immunodeficiency syndrome
KW - African-American
KW - ancillary services
KW - human immunodeficiency virus
KW - women
N1 - Accession Number: 13001643; Whetten, Kathryn 1,2 Reif, Susan 1,2 Lowe, Kristin 1,2; Email Address: KML@duke.edu Eldred, Lois 1,2; Affiliation: 1: Health Inequalities Program, Duke University Center for Health Policy, Law and Management, Durham, NC. 2: Health Resources and Services Administration, Demonstration Project Development and Evaluation Branch, Rockville, MD.; Source Info: Apr2004, Vol. 97 Issue 4, p342; Subject Term: HIV (Viruses); Subject Term: MEDICAL care; Subject Term: ANTIRETROVIRAL agents; Subject Term: AIDS (Disease); Subject Term: SEX differences (Biology); Subject Term: UNITED States; Author-Supplied Keyword: acquired immunodeficiency syndrome; Author-Supplied Keyword: African-American; Author-Supplied Keyword: ancillary services; Author-Supplied Keyword: human immunodeficiency virus; Author-Supplied Keyword: women; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13001643&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106675665
T1 - Implementing a national health information infrastructure to support the medical response to emerging microbial pathogens and bioterrorism.
AU - Rippen HE
AU - Gursky E
AU - Yasnoff WA
Y1 - 2004/04//Apr-Jun2004
N1 - Accession Number: 106675665. Language: English. Entry Date: 20041210. Revision Date: 20150818. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7906354.
KW - Bioterrorism
KW - Emergency Medical Service Communication Systems
KW - Systems Design
SP - 110
EP - 118
JO - Topics in Emergency Medicine
JF - Topics in Emergency Medicine
JA - TOP EMERG MED
VL - 26
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Emerging diseases and the threat of bioterrorist events are placing increasing demands on physicians. Although many emergency departments across the country are serving as sentries for these events, tools to help identify and respond to these challenges are still in early development or deployment. Moreover, many of these tools are stove-piped in approach, not providing benefits to the delivery of routine care. Coordinating efforts across healthcare and information technology communities through local health information infrastructures and the resulting national health information infrastructure can simultaneously improve our ability to detect and respond to emerging microbial threats and bioterrorism and enhance the quality and efficiency of routine care.
SN - 0164-2340
AD - National Health Information Infrastructure, US Department of Health and Human Services, Humphrey Building, 443F10, 220 Independence Ave, SW Washington, DC 20201; helga.rippen@hhs.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106675665&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gopee, Neera V.
AU - Johnson, Victor J.
AU - Sharma, Raghubir P.
T1 - Sodium Selenite-Induced Apoptosis in Murine B-Lymphoma Cells Is Associated with Inhibition of Protein Kinase C-δ, Nuclear Factor κB, and Inhibitor of Apoptosis Protein.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/04//
VL - 78
IS - 2
M3 - Article
SP - 204
EP - 214
PB - Oxford University Press / USA
SN - 10966080
AB - Selenium (Se) is an essential trace element possessing anticarcinogenic properties and other biological functions. This study determined the role sodium selenite plays on intracellular signaling, including protein kinase C (PKC), nuclear factor-kappa B (NF-κB), and inhibitor of apoptosis protein (IAP) in murine B lymphoma (A20) cells. In vitro supplementation of A20 cells with low concentrations of sodium selenite (0.005–5 μM) caused a significant increase in cellular proliferation exclusively at 72 h. Proliferation and cell viability were decreased in response to selenium concentrations of ≥ 25 μM and ≥ 5 μM at 72 and 96 h, respectively. Flow cytometric analysis of A20 cells exposed to 5 μM Se at 72 and 96 h indicated G2-M phase arrest and increased cell death at higher concentrations. Se-induced cytotoxicity was associated with apoptosis indicated by nuclear fragmentation and DNA laddering. Se concentrations, which induced cell cycle arrest and apoptosis, were associated with inhibition of cytosol to membrane translocation of PKCδ and PKC activity at 72 h. Coincubation of cultures with 0.5 μM phorbol 12-myristate 13-acetate (PMA) and Se (5 and 25 μM) reversed the Se-induced cell death at 72 h. The nuclear NF-κB translocation and NF-κB DNA-binding were inhibited by increasing concentrations of Se (5 and 25 μM) at 72 h. After 72 h exposure to 5 and 25 μM Se, cIAP-2 concentration was decreased. Differential inhibition of PKCδ, NF-κB, and cIAP-2 by Se may represent important intracellular signaling processes through which Se induces apoptosis and subsequently exerts its anticarcinogenic potential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Apoptosis
KW - Cell death
KW - Lymphomas
KW - Lymphoproliferative disorders
KW - B cells
KW - Protein kinase C
KW - cellular inhibitor of apoptosis protein-2
KW - nuclear factor-κB
KW - phorbol 12-myristate 13-acetate
KW - protein kinase C-δ
KW - selenium
N1 - Accession Number: 20620207; Gopee, Neera V. 1,2; Johnson, Victor J. 1,3; Sharma, Raghubir P. 1; Email Address: rpsharma@vet.uga.edu; Affiliations: 1: Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602-7389; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079; 3: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505; Issue Info: Apr2004, Vol. 78 Issue 2, p204; Thesaurus Term: Apoptosis; Thesaurus Term: Cell death; Subject Term: Lymphomas; Subject Term: Lymphoproliferative disorders; Subject Term: B cells; Subject Term: Protein kinase C; Author-Supplied Keyword: cellular inhibitor of apoptosis protein-2; Author-Supplied Keyword: nuclear factor-κB; Author-Supplied Keyword: phorbol 12-myristate 13-acetate; Author-Supplied Keyword: protein kinase C-δ; Author-Supplied Keyword: selenium; Number of Pages: 11p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfh072
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20620207&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2004-13202-001
AN - 2004-13202-001
AU - Scott, Lionel D. Jr.
T1 - Correlates of coping with perceived discriminatory experiences among African American adolescents.
JF - Journal of Adolescence
JO - Journal of Adolescence
JA - J Adolesc
Y1 - 2004/04//
VL - 27
IS - 2
SP - 123
EP - 137
CY - Netherlands
PB - Elsevier Science
SN - 0140-1971
SN - 1095-9254
AD - Scott, Lionel D. Jr., Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1093, One Brookings Drive, St. Louis, MO, US, 63130
N1 - Accession Number: 2004-13202-001. PMID: 15023512 Partial author list: First Author & Affiliation: Scott, Lionel D. Jr.; Washington U, George Warren Brown School of Social Work, Center for Mental Health Services Research, St Louis, MO, US. Release Date: 20040510. Correction Date: 20170123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Avoidance; Blacks; Coping Behavior; Discrimination. Minor Descriptor: Cross Cultural Differences. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: The Self-Report Coping Scale; The Racial Centrality subscale of the Multidimensional Inventory of Black Identity; The Racism-Related Socialization Influences Scale; The Racism Experiences Stress Scale; The Daily Life Experiences Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Apr, 2004.
AB - This study examined the relation of background and race-related factors to the use of approach and avoidance strategies to cope with perceived discriminatory experiences among a sample of African American adolescents of relative affluence (n = 71). Results showed that gender, family structure, socioeconomic status (SES), perceived control over discriminatory experiences, discrimination distress, and racism-related socialization were significant correlates of coping with perceived discriminatory experiences. Results concerning gender, perceived control, and stress arousal were consistent with findings from the general adolescent stress and coping literature. Results concerning family structure, SES, and socialization suggest that certain factors may be very important for the positive adjustment of African American adolescents in the face of race-related adversity. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - coping
KW - discriminatory experiences
KW - African American adolescents
KW - avoidance strategies
KW - 2004
KW - Avoidance
KW - Blacks
KW - Coping Behavior
KW - Discrimination
KW - Cross Cultural Differences
KW - 2004
DO - 10.1016/j.adolescence.2003.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13202-001&site=ehost-live&scope=site
UR - lscott@gwbmail.wustl.ed
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12677-003
AN - 2004-12677-003
AU - Roberts, Rashaun K.
AU - Swanson, Naomi G.
AU - Murphy, Lawrence R.
T1 - Discrimination and occupational mental health.
JF - Journal of Mental Health
JO - Journal of Mental Health
JA - J Ment Health
Y1 - 2004/04//
VL - 13
IS - 2
SP - 129
EP - 142
CY - United Kingdom
PB - Taylor & Francis
SN - 0963-8237
SN - 1360-0567
AD - Roberts, Rashaun K., National Institute for Occupational Safety and Health, 4676 Columbia Parkway, C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2004-12677-003. Partial author list: First Author & Affiliation: Roberts, Rashaun K.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20040503. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employment Discrimination; Mental Health; Race and Ethnic Discrimination; Racial and Ethnic Groups. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Apr, 2004.
AB - Background: Racial and ethnic discrimination has been shown to occur in work organizations, yet little is known about the relationship of this stressor to occupational mental health. Aims: This paper explores the degree to which racial and ethnic groups may be subjected to discrimination at work and examines associations between discrimination and mental health indicators. Methods: In a national study, 1,728 American workers were interviewed about aspects of their jobs, their exposure to racial and ethnic discrimination at work, and dimensions of their mental health. Results: American minorities reported perceptions of discrimination at work at greater frequencies than White Americans, and findings suggested some indication of institutional discrimination against minorities. Further, White, Black, and Hispanic-Americans, who reported that they had been discriminated against, were found to have poorer mental health outcomes than their same-race counterparts, who did not acknowledge being discriminated against. Conclusions: These findings may be used to inform the development of occupational stress and health models that are more cross-culturally applicable. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnic discrimination
KW - racial discrimination
KW - occupational mental health
KW - racial groups
KW - ethnic groups
KW - 2004
KW - Employment Discrimination
KW - Mental Health
KW - Race and Ethnic Discrimination
KW - Racial and Ethnic Groups
KW - 2004
DO - 10.1080/09638230410001669264
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12677-003&site=ehost-live&scope=site
UR - rsr3@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-13704-002
AN - 2004-13704-002
AU - Humphreys, Keith
AU - Wing, Stephen
AU - McCarty, Dennis
AU - Chappel, John
AU - Gallant, Lewis
AU - Haberle, Beverly
AU - Horvath, A. Thomas
AU - Kaskutas, Lee Ann
AU - Kirk, Thomas
AU - Kivlahan, Daniel
AU - Laudet, Alexandre
AU - McCrady, Barbara S.
AU - McLellan, A. Thomas
AU - Morgenstern, Jon
AU - Townsend, Mike
AU - Weiss, Roger
T1 - Self-help organizations for alcohol and drug problems: Toward evidence-based practice and policy.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2004/04//
VL - 26
IS - 3
SP - 151
EP - 158
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Humphreys, Keith, Substance Abuse and Mental Health Services Administration/Veterans Health Administration Workgroup on Substance Abuse Self-Help Organizations, c/o Program Evaluation and Resource Center, Veterans Affairs Health Care System (152-MPD), 795 Willow Road, Menlo Park, CA, US, 94025
N1 - Accession Number: 2004-13704-002. PMID: 15063905 Partial author list: First Author & Affiliation: Humphreys, Keith; Substance Abuse and Mental Health Services Administration/Veterans Health Administration Workgroup on Substance Abuse Self-Help Organizations, Menlo Park, CA, US. Release Date: 20040510. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Organizations; Self-Help Techniques; Support Groups; Treatment Effectiveness Evaluation. Minor Descriptor: Clinicians; Drug Abuse; Drug Addiction; Government Policy Making; Treatment Outcomes. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2004.
AB - This expert consensus statement reviews evidence on the effectiveness of drug and alcohol self-help groups and presents potential implications for clinicians, treatment program managers and policymakers. Because longitudinal studies associate self-help group involvement with reduced substance use, improved psychosocial functioning, and lessened health care costs, there are humane and practical reasons to develop self-help group supportive policies. Policies described here that could be implemented by clinicians and program managers include making greater use of empirically-validated self-help group referral methods in both specialty and non-specialty treatment settings and developing a menu of locally available self-help group options that are responsive to client's needs, preferences, and cultural background. The workgroup also offered possible self-help supportive policy options (e.g., supporting self-help clearinghouses) for state and federal decision makers. Implementing such policies could strengthen alcohol and drug self-help organizations, and thereby enhance the national response to the serious public health problem of substance abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - expert consensus statement
KW - self-help organizations
KW - policymakers
KW - implications
KW - program managers
KW - group involvement
KW - substance use
KW - psychosocial functioning
KW - self-help clearinghouse
KW - referral methods
KW - 2004
KW - Drug Rehabilitation
KW - Organizations
KW - Self-Help Techniques
KW - Support Groups
KW - Treatment Effectiveness Evaluation
KW - Clinicians
KW - Drug Abuse
KW - Drug Addiction
KW - Government Policy Making
KW - Treatment Outcomes
KW - 2004
DO - 10.1016/S0740-5472(03)00212-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13704-002&site=ehost-live&scope=site
UR - KNH@Stanford.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-03759-003
AN - 2011-03759-003
AU - Katz, Russell
T1 - Biomarkers and surrogate markers: An FDA perspective.
JF - NeuroRX®
JO - NeuroRX®
JA - NeuroRx
Y1 - 2004/04//
VL - 1
IS - 2
SP - 189
EP - 195
CY - Netherlands
PB - Elsevier Science
SN - 1545-5343
AD - Katz, Russell, Food and Drug Administration, 1451 Rockville Pike, Room 4037, Rockville, MD, US, 20852
N1 - Accession Number: 2011-03759-003. PMID: 15717019 Other Journal Title: Neurotherapeutics. Partial author list: First Author & Affiliation: Katz, Russell; Division of Neuropharmacological Drug Products, United States Food and Drug Administration, Rockville, MD, US. Other Publishers: Springer. Release Date: 20110627. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Biological Markers; Drugs; Mental Disorders. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2004. Copyright Statement: The American Society for Experimental NeuroTherapeutics, Inc.
AB - Interest is increasing rapidly in the use of surrogate markers as primary measures of the effectiveness of investigational drugs in definitive drug trials. Many such surrogate markers have been proposed as potential candidates for use in definitive effectiveness trials of agents to treat neurologic or psychiatric disease, but as of this date, there are no such markers that have been adequately 'validated,' that is, shown to predict the effect of the treatment on the clinical outcome of interest. While the current law and regulations permit the United States Food and Drug Administration to base the approval of a drug product on a determination the effect of the drug on an unvalidated surrogate marker (that is, one for which it is not known that an effect on the surrogate actually predicts the desired clinical benefit), there are a number of difficulties in interpreting trials that use surrogate markers as primary measures of drug effect. In this article, the relevant regulatory context will be discussed, as well as the epistemological problems related to the interpretation of clinical trials in which unvalidated surrogate markers are used as primary outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - biomarkers
KW - surrogate markers
KW - investigational drugs
KW - drug trials
KW - psychiatric disease
KW - Food and Drug Administration
KW - 2004
KW - Biological Markers
KW - Drugs
KW - Mental Disorders
KW - 2004
DO - 10.1602/neurorx.1.2.189
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-03759-003&site=ehost-live&scope=site
UR - katzr@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12786-001
AN - 2004-12786-001
AU - Weinick, Robin M.
AU - Jacobs, Elizabeth A.
AU - Stone, Lisa Cacari
AU - Ortega, Alexander N.
AU - Burstin, Helen
T1 - Hispanic Healthcare Disparities: Challenging the Myth of a Monolithic Hispanic Population.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2004/04//
VL - 42
IS - 4
SP - 313
EP - 320
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Weinick, Robin M., Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2004-12786-001. PMID: 15076807 Partial author list: First Author & Affiliation: Weinick, Robin M.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20050307. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Care Utilization; Race and Ethnic Discrimination; Racial and Ethnic Groups; Latinos/Latinas. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2004.
AB - Background: Hispanic Americans are often treated as a monolithic ethnic group with a single pattern of healthcare utilization. However, there could be considerable differences within this population. We examine the association between use of healthcare services and Hispanic Americans' country of ancestry or origin, language of interview, and length of time lived in the United States. Methods: Our data come from the Medical Expenditure Panel Survey, a nationally representative survey of healthcare use and expenditures. Descriptive statistics and logistic regression results are presented. Results: Multivariate models show that Mexicans and Cubans are less likely, and Puerto Ricans more likely, to have any emergency department visits than non-Hispanic whites. Mexicans, Central American/Caribbeans, and South Americans are less likely to have any prescription medications. All Hispanics are less likely to have any ambulatory visits and prescription medications, whereas only those with a Spanish-language interview are less likely to have emergency department visits and inpatient admissions. More recent immigrants are less likely to have any ambulatory care or emergency department visits, whereas all Hispanics born outside the United States are less likely to have any prescription medications. Conclusions: The Hispanic population is composed of many different groups with diverse health needs and different barriers to accessing care. Misconceptions of Hispanics as a monolithic population lacking within-group diversity could function as a barrier to efforts aimed at providing appropriate care to Hispanic persons and could be 1 factor contributing to inequalities in the availability, use, and quality of healthcare services in this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Hispanic Americans
KW - health care disparities
KW - monolithic ethnic group
KW - healthcare utilization
KW - healthcare services
KW - 2004
KW - Health Care Services
KW - Health Care Utilization
KW - Race and Ethnic Discrimination
KW - Racial and Ethnic Groups
KW - Latinos/Latinas
KW - 2004
DO - 10.1097/01.mlr.0000118705.27241.7c
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12786-001&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6861-6993
UR -
UR - rweinick@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12205-005
AN - 2004-12205-005
AU - Lowe, Brian D.
T1 - Accuracy and validity of observational estimates of wrist and forearm posture.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2004/04//
VL - 47
IS - 5
SP - 527
EP - 554
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Lowe, Brian D., National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2004-12205-005. PMID: 15204302 Partial author list: First Author & Affiliation: Lowe, Brian D.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20050214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Observation Methods; Posture; Statistical Validity; Wrist. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 28. Issue Publication Date: Apr, 2004.
AB - Numerous observational methods for analysis of working posture of the wrist/forearm have been reported in the literature yet few of these methods have been validated for the accuracy of their posture classification. The present study evaluated the accuracy of estimates of working posture made by 28 experienced ergonomists using methods of scaling upper limb posture typical of those reported in the literature. Observational estimates of wrist/forearm posture of four jobs presented on video-recording were compared with posture levels measured directly with an electrogoniometer system. Ergonomists using a visual analogue scale tended to underestimate peak and average wrist extension with mean errors of -29.4% and -10.5% of the joint ROM, respectively (p < 0.05). While estimates of wrist flexion, pronation and supination resulted in less bias, variability in observer error was large for all wrist postures. The probability of an analyst misclassifying the most frequently occurring posture using a three- and a six-category scale was 54 and 70%, respectively. The probability of misclassifying peak posture was 22 and 61% using a three- and a six-category scale respectively. This suggests a trade-off between the degree of precision afforded by the categorical scale and the likelihood of posture misclassification. Estimates of the temporal distribution of posture among the categories appeared to be biased towards more neutral postures than were measured for the jobs. This indicated the possibility of a trend towards underestimation of posture duration severity by the ergonomists. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - wrist posture
KW - forearm posture
KW - working posture
KW - observational methods
KW - accuracy
KW - validity
KW - ergonomics
KW - 2004
KW - Human Factors Engineering
KW - Observation Methods
KW - Posture
KW - Statistical Validity
KW - Wrist
KW - 2004
DO - 10.1080/00140130310001653057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12205-005&site=ehost-live&scope=site
UR - blowe@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-12890-001
AN - 2004-12890-001
AU - Stryer, Daniel B.
AU - Siegel, Joanna E.
AU - Rodgers, Anne Brown
T1 - Outcomes Research: Priorities for an Evolving Field.
T3 - Outcomes Research: New Priorities for an Evolving Field
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2004/04//
VL - 42
IS - Suppl4
SP - III-1
EP - III-5
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Stryer, Daniel B., Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2004-12890-001. Partial author list: First Author & Affiliation: Stryer, Daniel B.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20050228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Experimentation; Health; Intervention; Quality of Life; Treatment Outcomes. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2004.
AB - Outcomes research, research that evaluates the impact of health care on the health outcomes of patients and populations, has been a priority for the Agency for Healthcare Research and Quality (AHRQ) since the agency's inception in 1989. Consistent with AHRQ's mission, outcomes and effectiveness research emphasizes health problem- or disease- oriented evaluations of care delivered in 'real-world' settings. Outcomes research includes evaluation of the impact of both discrete healthcare interventions such as drugs, medical devices, and procedures and broad programmatic or system-level interventions. It assesses impact on a spectrum of health outcomes that could include mortality, morbidity, functional status, mental well being, and other aspects of health-related quality of life, and it could include evaluation of economic impacts linked to health outcomes. Outcomes research could use any of a variety of primary data collection methods, or it could rely on secondary methods that combine data from primary studies. Although outcomes research has led to impressive gains in our understanding of the healthcare system, how to measure its performance and how to transform it, outcomes research itself must also evolve in response to new demands, new realities, and cumulative experience. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - outcomes research
KW - health outcomes
KW - health care interventions
KW - quality of life
KW - 2004
KW - Experimentation
KW - Health
KW - Intervention
KW - Quality of Life
KW - Treatment Outcomes
KW - 2004
DO - 10.1097/01.mlr.0000119324.73834.3b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-12890-001&site=ehost-live&scope=site
UR - dstryer@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cieślak, Jacek
AU - Grajkowski, Andrzej
AU - Livengood, Victor
AU - Beaucage, Serge L.
T1 - Thermolytic 4-Methylthio-1-butyl Group for Phosphate/Thiophosphate Protection in Solid-Phase Synthesis of DNA Oligonucleotides.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2004/04/02/
VL - 69
IS - 7
M3 - Article
SP - 2509
EP - 2515
SN - 00223263
AB - The thermolabile 4-methylthio-1-butyl phosphate/thiophosphate protecting group for DNA oligonucleotides has been investigated for its potential application to a "heat-driven" process for either oligonucleotide synthesis on diagnostic microarrays or, oppositely, to the large-scale preparation of therapeutic oligonucleotides. The preparation of phosphoramidites 10a-d is straightforward, and the incorporation of these amidites into oligonucleotides via solid-phase techniques proceeds as efficiently as that achieved with 2-cyanoethyl deoxyribonucleoside phosphoramidites. The versatility of the 4-methylthio-1-butyl phosphate/thiophosphate protecting group is exemplified by its facile removal from oligonucleotides upon heating for 30 min at 55 °C in an aqueous buffer under neutral conditions or within 2 h at 55 °C in concentrated NH4OH. The deprotection reaction occurs through an intramolecular cyclodeesterification mechanism leading to the formation of sulfonium salt 18. When mixed with deoxyribonucleosides and N-protected 2'-deoxyribonucleosides or with a model phosphorothioate diester under conditions approximating those of large-scale (> 50 mmol) oligonucleotide deprotection reactions, the salt 18 did not significantly alter DNA nucleobases or desulfurize the phosphorothioate diester model to an appreciable extent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLIGONUCLEOTIDES
KW - DNA
KW - ORGANIC synthesis (Chemistry)
KW - PHOSPHATES
KW - SULFUR compounds
KW - ESTERS
N1 - Accession Number: 12977709; Cieślak, Jacek 1 Grajkowski, Andrzej 2 Livengood, Victor 3 Beaucage, Serge L. 2; Email Address: beaucage@cber.fda.gov; Affiliation: 1: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland 2: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland 3: Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Maryland; Source Info: 4/2/2004, Vol. 69 Issue 7, p2509; Subject Term: OLIGONUCLEOTIDES; Subject Term: DNA; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: PHOSPHATES; Subject Term: SULFUR compounds; Subject Term: ESTERS; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 7p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1021/jo035861f
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12977709&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pratt, S.
T1 - Work-Related Roadway Crashes--United States, 1992--2002.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/04/02/
VL - 53
IS - 12
M3 - Article
SP - 260
EP - 264
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the results of an analysis of from the Fatality Analysis Reporting System of the U.S. National Highway Traffic Safety Administration and the Census of Fatal Occupational Injuries of the U.S. Bureau of Labor Statistics for the period 1992 to 2002. Number of workers who were classified as motor-vehicle operators in 2001; Causes of vehicle crashes; Vehicles that are most commonly involved in the crashes; Policies that should be considered for safe workplace driving.
KW - TRAFFIC accidents
KW - WORK-related injuries
KW - AUTOMOBILE drivers
KW - AUTOMOBILE driving
KW - UNITED States
KW - UNITED States. National Highway Traffic Safety Administration
KW - UNITED States. Bureau of Labor Statistics
N1 - Accession Number: 12912619; Pratt, S. 1; Affiliation: 1: Div of Safety Research, National Institute for Occupational Safety and Health, CDC; Source Info: 4/2/2004, Vol. 53 Issue 12, p260; Subject Term: TRAFFIC accidents; Subject Term: WORK-related injuries; Subject Term: AUTOMOBILE drivers; Subject Term: AUTOMOBILE driving; Subject Term: UNITED States; Company/Entity: UNITED States. National Highway Traffic Safety Administration Company/Entity: UNITED States. Bureau of Labor Statistics; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 926120 Regulation and Administration of Transportation Programs; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aronson, N.
AU - Ananthakrishnan, M.
AU - Berstein, W.
AU - Hochberg, L.
AU - Marovich, M.
AU - Ockenhouse, C.
AU - Yoon, I.
AU - Weina, P.
AU - Benson, P.
AU - Fischer, J.
AU - Hack, D.
AU - Hawkes, C.
AU - Polhemus, M.
AU - Wortmann, G.
AU - McEvoy, P.
AU - Neafie, R.
AU - Defraites, R.
AU - Herwaldt, B. L.
T1 - Update: Cutaneous Leishmaniasis in U.S. Military Personnel -- Southwest/Central Asia, 2002--2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/04/02/
VL - 53
IS - 12
M3 - Article
SP - 264
EP - 265
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Presents information on cases of cutaneous leishmaniasis (CL) in U.S. military personnel deployed to Afghanistan, Iraq and Kuwait from August 2002 to February 2004. Percentage of CL military patients who were non-Hispanic white; Measures implemented by the Department of Defense to decrease the risk of CL.
KW - CUTANEOUS leishmaniasis
KW - MILITARY hygiene
KW - MILITARY personnel -- United States
KW - DEPLOYMENT (Military strategy)
KW - HISPANIC American soldiers
KW - UNITED States
KW - UNITED States. Dept. of Defense
N1 - Accession Number: 12912625; Aronson, N. 1 Ananthakrishnan, M. 2 Berstein, W. 2 Hochberg, L. 2 Marovich, M. 2 Ockenhouse, C. 2 Yoon, I. 2 Weina, P. 2 Benson, P. 3 Fischer, J. 3 Hack, D. 3 Hawkes, C. 3 Polhemus, M. 3 Wortmann, G. 3 McEvoy, P. 4 Neafie, R. 4 Defraites, R. 5 Herwaldt, B. L. 6; Affiliation: 1: Uniformed Svcs Univ of the Health Sciences, Bethesda 2: Walter Reed Army Institute of Research, Silver Spring, Maryland 3: Walter Reed Army Medical Center, CDC 4: Armed Forces Institute of Pathology, District of Columbia 5: Office of the Surgeon General of the Army, Alexandria, Virginia 6: Div of Parasitic Diseases, National Center for Infectious Diseases, CDC; Source Info: 4/2/2004, Vol. 53 Issue 12, p264; Subject Term: CUTANEOUS leishmaniasis; Subject Term: MILITARY hygiene; Subject Term: MILITARY personnel -- United States; Subject Term: DEPLOYMENT (Military strategy); Subject Term: HISPANIC American soldiers; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Defense; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haffner, Marlene E.
T1 - Developing treatments for inborn errors: incentives available to the clinician
JO - Molecular Genetics & Metabolism
JF - Molecular Genetics & Metabolism
Y1 - 2004/04/02/Apr2004 Supplement
VL - 81
M3 - Article
SP - 63
SN - 10967192
AB - Disorders resulting from inborn errors of metabolism (IEM) affect very small numbers of individuals. The entire population, however, of patients suffering the results of inherited metabolic disorders is large, and has been of increasing concern to patient groups and health care professionals in the United States as well as other countries throughout the world. The 1983 US Orphan Drug Act (ODA) serves to facilitate the development of drugs to treat rare diseases by providing several economic incentives. The sponsor of a product designated as an orphan by the Food & Drugs Administration (FDA) Office of Orphan Products Development (OPD) qualifies for tax credits on clinical trial expenses, the award of grant funding by FDA, through the OPD, and 7 years of marketing exclusivity for a designated drug, or biological product that receives FDA market approval. Orphan drug legislation in the US has benefited victims of IEM by encouraging development of drugs for metabolic deficiencies affecting populations that otherwise would be ignored. America’s solution to the orphan drug problem has had worldwide impact. The success of this legislation was a factor leading to the 1993 orphan drug law in Japan; the 1997 implementation of a process whereby most FDA-approved orphan drugs and biological products will be similarly approved in Australia; and, in 1999, regulation on orphan medicinal products in the European Union (EU). Today, international support for rare disease research is providing stimulus and motivation to overcome the financial barriers and encourage development of treatment for very rare diseases throughout the world. [Copyright &y& Elsevier]
AB - Copyright of Molecular Genetics & Metabolism is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORPHAN drugs
KW - CLINICAL drug trials
KW - GENETIC disorders
KW - LEGISLATION
KW - Incentives
KW - Orphan
KW - Orphan drug act
KW - Rare disease
KW - Research grants
N1 - Accession Number: 12709723; Haffner, Marlene E. 1; Email Address: mhaffner@oc.fda.gov; Affiliation: 1: FDA Office of Orphan Products Development, Food and Drug Administration, Rockville, MD 20857, USA; Source Info: Apr2004 Supplement, Vol. 81, p63; Subject Term: ORPHAN drugs; Subject Term: CLINICAL drug trials; Subject Term: GENETIC disorders; Subject Term: LEGISLATION; Author-Supplied Keyword: Incentives; Author-Supplied Keyword: Orphan; Author-Supplied Keyword: Orphan drug act; Author-Supplied Keyword: Rare disease; Author-Supplied Keyword: Research grants; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ymgme.2003.10.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12709723&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weiss, Bernard
AU - Amler, Sherlita
AU - Amler, Robert W.
T1 - Pesticides.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/04/02/Apr2004 Supplement
VL - 113
M3 - Article
SP - 1030
EP - 1036
PB - American Academy of Pediatrics
SN - 00314005
AB - Pesticides are a broad group of heterogeneous chemicals that have a significant public health benefit by increasing food production productivity and decreasing food-borne and vector-borne diseases. However, depending on the agent and the exposure, they may pose health risks. Because of their behavior, acute accidental toxic exposures occur more commonly in children. Because of the dietary habits and greater intake of foods per kilogram in children and because some infants are breastfed, there is also concern about the effects on them of low-level environmental exposures. In the absence of direct conclusive evidence, consistent and relevant observations have led some investigators to infer that chronic low-dose exposure to certain pesticides might pose a potential hazard to the health and development of infants and children. Other investigators have concluded that such inferences can be neither supported nor refuted at the present time. The pediatrician has a role to play in recognizing the symptoms of acute exposure and to be able to provide appropriate treatment. It is essential to study whether there are subtle neurologic effects that may result from low-level pesticide exposures in individual patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - PEDIATRICS
KW - PUBLIC health
KW - HEALTH risk assessment
KW - CHILD development
KW - NEUROTOXICOLOGY
KW - behavior
KW - brain development
KW - endocrine disruption
KW - neurotoxicity
KW - pesticides
N1 - Accession Number: 12518226; Weiss, Bernard 1; Email Address: bernard_weiss@urmc.rochester.edu Amler, Sherlita 2 Amler, Robert W. 2; Affiliation: 1: Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 2: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia; Source Info: Apr2004 Supplement, Vol. 113, p1030; Subject Term: PESTICIDES; Subject Term: PEDIATRICS; Subject Term: PUBLIC health; Subject Term: HEALTH risk assessment; Subject Term: CHILD development; Subject Term: NEUROTOXICOLOGY; Author-Supplied Keyword: behavior; Author-Supplied Keyword: brain development; Author-Supplied Keyword: endocrine disruption; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: pesticides; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mone, Suzanne M.
AU - Gillman, Matthew W.
AU - Miller, Tracie L.
AU - Herman, Eugene H.
AU - Lipshultz, Steven E.
T1 - Effects of Environmental Exposures on the Cardiovascular System: Prenatal Period Through Adolescence.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/04/02/Apr2004 Supplement
VL - 113
M3 - Article
SP - 1058
EP - 1069
PB - American Academy of Pediatrics
SN - 00314005
AB - Exposures to drugs, chemical and biological agents, therapeutic radiation, and other factors before and after birth can lead to pediatric or adult cardiovascular anomalies. Furthermore, nutritional deficiencies in the perinatal period can cause cardiovascular anomalies. These anomalies may affect heart structure, the conduction system, the myocardium, blood pressure, or cholesterol metabolism. Developmental periods before and after birth are associated with different types of risks. The embryonic period is the critical window of vulnerability for congenital malformations. The fetal period seems to have lifelong effects on coronary heart disease and its precursors. During the weeks immediately after birth, susceptibility to myocardial damage seems to be high. Exposure to cancer chemotherapy or radiotherapy in childhood raises the risk of long-term progressive left ventricular dysfunction and other cardiovascular problems. In childhood and adolescence, use of recreational drugs such as cocaine and tobacco poses cardiovascular dangers as well. Where evidence about environmental exposures is limited, we have included models of disease and other exposures that are suggestive of the potential impact of environmental exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENVIRONMENTAL toxicology
KW - TOXICOLOGY
KW - CARDIOVASCULAR diseases
KW - CHILD development
KW - DEVELOPMENTAL biology
KW - cardiovascular system
KW - environmental exposures
KW - fetal
KW - pediatric
N1 - Accession Number: 12518281; Mone, Suzanne M. 1 Gillman, Matthew W. 2,3 Miller, Tracie L. 4,5 Herman, Eugene H. 6 Lipshultz, Steven E. 5,7,8; Email Address: SLipshultz@med.miami.edu; Affiliation: 1: Division of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 3: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 4: Division of Pediatric Clinical Research, University of Miami School of Medicine, Miami, Florida 5: Holtz Children's Hospital-Jackson Memorial Medical Center, University of Miami School of Medicine, Miami, Florida 6: Division of Applied Pharmacology Research (HFD-910), Food and Drug Administration, Laurel, Maryland 7: Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 8: Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida; Source Info: Apr2004 Supplement, Vol. 113, p1058; Subject Term: ENVIRONMENTAL toxicology; Subject Term: TOXICOLOGY; Subject Term: CARDIOVASCULAR diseases; Subject Term: CHILD development; Subject Term: DEVELOPMENTAL biology; Author-Supplied Keyword: cardiovascular system; Author-Supplied Keyword: environmental exposures; Author-Supplied Keyword: fetal; Author-Supplied Keyword: pediatric; Number of Pages: 12p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12518281&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Solhaug, Michael J.
AU - Bolger, Philip M.
AU - Jose, Pedro A.
T1 - The Developing Kidney and Environmental Toxins.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/04/02/Apr2004 Supplement
VL - 113
M3 - Article
SP - 1084
EP - 1091
PB - American Academy of Pediatrics
SN - 00314005
AB - The effects of environmental chemicals, drugs, and physical agents on the developing kidney are influenced by the state of renal development and maturation. The development of the kidney, the major excretory organ after birth, consists of 3 stages: the pronephros, or cervical kidney; mesonephros, or thoracic kidney; and metanephros, or abdominal kidney, the definitive kidney. In humans, nephrogenesis and organo-genesis occur from the 6th to the 36th weeks of gestational age. After 36 weeks, nephrogenesis is complete and each kidney has a full complement of nephrons. The extent of chemical-induced renal toxicity is related, in part, to the efficiency in which the particular compound is transported by renal tubules. Because renal tubular transport capacities vary with maturation, the degree of nephrotoxicity may also vary with maturation. The signs and symptoms of nephrotoxicity can appear acutely or insidiously. Unexplained acute renal failure, chronic mild proteinuria, or even hypertension can be a manifestation of nephrotoxic agents. Species differences occur, thus the need for studies in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENVIRONMENTAL toxicology
KW - TOXICOLOGY
KW - KIDNEY diseases
KW - TOXINS
KW - NEPHROTOXICOLOGY
KW - angiotensin
KW - development
KW - kidney
KW - prostanoids
KW - toxins
N1 - Accession Number: 12519040; Solhaug, Michael J. 1 Bolger, Philip M. 2 Jose, Pedro A. 3; Email Address: pjose01@georgetown.edu; Affiliation: 1: Department of Physiology, Eastern Virginia School of Medicine, Norfolk, Virginia 2: Food and Drug Administration, Washington, DC 3: Department of Pediatrics and Physiology and Biophysics, Georgetown University Medical Center, Washington, DC; Source Info: Apr2004 Supplement, Vol. 113, p1084; Subject Term: ENVIRONMENTAL toxicology; Subject Term: TOXICOLOGY; Subject Term: KIDNEY diseases; Subject Term: TOXINS; Subject Term: NEPHROTOXICOLOGY; Author-Supplied Keyword: angiotensin; Author-Supplied Keyword: development; Author-Supplied Keyword: kidney; Author-Supplied Keyword: prostanoids; Author-Supplied Keyword: toxins; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - B’Hymer, C.
AU - Cheever, K.L.
T1 - Development of a gas chromatographic test for the quantification of the biomarker 3-bromopropionic acid in human urine
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2004/04/05/
VL - 802
IS - 2
M3 - Article
SP - 361
SN - 15700232
AB - An accurate and precise method was developed for the detection and quantification of 3-bromopropionic acid (3-BPA), a metabolite and biomarker for exposure to 1-bromopropane (1-BP). 1-BP is used as an industrial solvent and exposure is a health concern for industrial workers due to its toxicity. It has been associated with neurological disorders in both animals and humans. Urine sample preparation for the determination of 3-BPA consisted of liquid–liquid extraction (LLE) with ethyl acetate and silylation with N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide (MTBSTFA). Quantification was by means of a gas chromatograph (GC) equipped with a mass selective detector (MSD) using a dimethylpolysiloxane (HP-1) capillary column and 3-chloropropionic acid was used as an internal standard in the procedure. Demonstrated accuracy and precision during this method’s validation was good; recovery varied between 93 and 98% with relative standard deviations (R.D.S.) of 5.7% or less. The limit of detection (LOD) for the procedure was approximately 0.01 μg/ml 3-BPA in urine. These data and other factors of the development and validation of this test method will be discussed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROPIONIC acid
KW - FATTY acids
KW - BIOCHEMICAL markers
KW - SOLVENTS
KW - TOXICOLOGY
KW - NERVOUS system -- Diseases
KW - 1-Bromopropane
KW - 3-Bromopropionic acid
N1 - Accession Number: 12375078; B’Hymer, C.; Email Address: cbhymer@cdc.gov Cheever, K.L. 1; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Taft Laboratory C-26, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Apr2004, Vol. 802 Issue 2, p361; Subject Term: PROPIONIC acid; Subject Term: FATTY acids; Subject Term: BIOCHEMICAL markers; Subject Term: SOLVENTS; Subject Term: TOXICOLOGY; Subject Term: NERVOUS system -- Diseases; Author-Supplied Keyword: 1-Bromopropane; Author-Supplied Keyword: 3-Bromopropionic acid; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jchromb.2003.12.004
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Powers, John H.
AU - Higgins, Karen M.
T1 - Itraconazole versus Fluconazole for Antifungal Prophylaxis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2004/04/06/
VL - 140
IS - 7
M3 - Letter
SP - 580
EP - 580
SN - 00034819
AB - Presents a letter to the editor in response to the article "Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients:A multicenter, randomized trial," by D. J. Winston et al., published in a previous issue.
KW - LETTERS to the editor
KW - ANTIFUNGAL agents
KW - HEMATOPOIETIC stem cells -- Transplantation
N1 - Accession Number: 12735498; Powers, John H. 1 Higgins, Karen M. 1; Affiliation: 1: U.S. Food and Drug Administration, Rockville, MD 20850; Source Info: 4/6/2004, Vol. 140 Issue 7, p580; Subject Term: LETTERS to the editor; Subject Term: ANTIFUNGAL agents; Subject Term: HEMATOPOIETIC stem cells -- Transplantation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Auch, Corey J.
AU - Saha, Ramendra N.
AU - Sheikh, Faruk G.
AU - Liu, Xiaojuan
AU - Jacobs, Bertram L.
AU - Pahan, Kalipada
T1 - Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia
JO - FEBS Letters
JF - FEBS Letters
Y1 - 2004/04/09/
VL - 563
IS - 1-3
M3 - Article
SP - 223
SN - 00145793
AB - Environmental factor(s), such as viral infection, has been implicated as one of the triggering events leading to neuroinflammation in multiple sclerosis. This study underlines the importance of double-stranded RNA (dsRNA), the active component of a viral infection, in inducing the expression of inducible nitric oxide synthase (iNOS) in human astroglia. DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-κB and CCAAT/enhancer-binding proteinβ (C/EBPβ). In addition, we show that inhibitors of protein kinase R attenuated iNOS by suppressing the activation of NF-κB but not C/EBPβ. In contrast, knock down of p38 mitogen-activated protein kinase (MAPK) attenuated iNOS by suppressing the activation of C/EBPβ but not NF-κB. This study delineates a novel role of dsRNA in inducing the expression of iNOS through dsRNA-activated protein kinase (PKR)-mediated activation of NF-κB and p38-mediated activation of C/EBPβ in human astroglia that may participate in virus-induced neurological abnormalities. [Copyright &y& Elsevier]
AB - Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinases
KW - RNA
KW - NEUROLOGY
KW - MITOGENS
KW - CCAAT/enhancer-binding proteinβ
KW - Double-stranded RNA
KW - Human astroglia
KW - Inducible nitric oxide synthase
KW - Nuclear factor-κB
N1 - Accession Number: 12745092; Auch, Corey J. 1 Saha, Ramendra N. 1 Sheikh, Faruk G. 2 Liu, Xiaojuan 1 Jacobs, Bertram L. 3 Pahan, Kalipada 1; Email Address: kpahan@unmc.edu; Affiliation: 1: Department of Oral Biology, University of Nebraska Medical Center, 40th and Holdrege, Lincoln, NE 68583-0740, USA 2: Division of Therapeutic Protein, Food and Drug Administration, Bethesda, MD 20892, USA 3: Department of Microbiology, Arizona State University, Tempe, AZ 85287, USA; Source Info: Apr2004, Vol. 563 Issue 1-3, p223; Subject Term: PROTEIN kinases; Subject Term: RNA; Subject Term: NEUROLOGY; Subject Term: MITOGENS; Author-Supplied Keyword: CCAAT/enhancer-binding proteinβ; Author-Supplied Keyword: Double-stranded RNA; Author-Supplied Keyword: Human astroglia; Author-Supplied Keyword: Inducible nitric oxide synthase; Author-Supplied Keyword: Nuclear factor-κB; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0014-5793(04)00302-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lipscomb, John C.
AU - Barton, Hugh A.
AU - Tornero-Velez, Rogelio
AU - Evans, Marina V.
AU - Alcasey, Sattar
AU - Snawder, John E.
AU - Laskey, John
T1 - The Metabolic Rate Constants and Specific Activity of Human and Rat Hepatic Cytochrome P-450 2E1 Toward Toluene and Chloroform.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/04/09/
VL - 67
IS - 7
M3 - Article
SP - 537
EP - 553
SN - 15287394
AB - Chloroform (CHCl 3 ) is a near-ubiquitous environmental contaminant, a by-product of the disinfection of drinking water sources and a commercially important compound. Standards for safe exposure have been established based on information defining its toxicity, which is mediated by metabolites. The metabolism of CHCl 3 is via cytochrome P-450 2E1 (CYP2E1)-mediated oxidation to phosgene, which is known to obey a saturable mechanism. CYP2E1 is a highly conserved form, expressed in all mammalian systems studied, and is responsible for the metabolism of a great many low-molecular-weight (halogenated) compounds. However, the Michaelis-Menten rate constants for CHCl 3 oxidation have not been derived in vitro, and the specific activity of CYP2E1 toward CHCl 3 has not been reported. In this investigation with microsomal protein (MSP), apparent V max values of 27.6 and 28.3 nmol/h/mg MSP and apparent K m values of 1 and 0.15 μM in rats and human organ donors, respectively, were demonstrated. The specific activity of CYP2E1 toward CHCl 3 in rats and humans was 5.29 and 5.24 pmol/min/pmol CYP2E1, respectively. Toluene metabolism to benzyl alcohol (BA), another CYP2E1-dependent reaction, was also highly dependent on CYP2E1 content in humans, and was more efficient than was CHCl 3 metabolism. The specific activity of human CYP2E1 toward toluene metabolism in human MSP was 23 pmol/min/pmol CYP2E1. These results demonstrate that differences in CYP2E1 content of MSP among individuals and between species are largely responsible for observed differences in toluene and CHCl 3 metabolism in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLOROFORM
KW - DRINKING water
KW - CYTOCHROME P-450
KW - MOLECULAR weights
KW - MAMMALS
KW - PHOSGENE
N1 - Accession Number: 12453919; Lipscomb, John C. 1; Email Address: Iipscomb.john@epa.gov Barton, Hugh A. 2 Tornero-Velez, Rogelio 3 Evans, Marina V. 2 Alcasey, Sattar 2 Snawder, John E. 4 Laskey, John 5; Affiliation: 1: U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Cincinnati, Ohio, USA. 2: U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA. 3: U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, North Carolina, USA. 4: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. 5: National Caucus and Center on Black Aged Inc., Senior Environmental Program (NCBA-SEP), Research Triangle Park, North Carolina, USA.; Source Info: 2004, Vol. 67 Issue 7, p537; Subject Term: CHLOROFORM; Subject Term: DRINKING water; Subject Term: CYTOCHROME P-450; Subject Term: MOLECULAR weights; Subject Term: MAMMALS; Subject Term: PHOSGENE; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1080/15287390490425588
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - James, S. Jill
AU - Jernigan, Stefanie
AU - Pogribna, Marta
T1 - Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/04/14/
VL - 548
IS - 1/2
M3 - Article
SP - 53
SN - 00275107
AB - Chronic dietary insufficiency of the lipotropic nutrients choline and methionine is hepatocarcinogenic in male rats and certain mouse strains. Despite the fact that DNA hypomethylation is a hallmark of most cancer genomes, the tissue-specific consequences of this alternation with respect to tumorigenesis remain to be determined. In the present study, the folate/methyl deficient model of multistage hepatocarcinogenesis was used to evaluate in vivo alterations in DNA methylation in the liver, the carcinogenesis target tissue, and in non-target tissues, including pancreas, spleen, kidney, and thymus, of male F344 rats. By utilizing the HpaII/MspI-based cytosine extension assay, we demonstrated that the percent of CpG sites that lost methyl groups on both strands progressively increased in liver tissue after 9, 18, and 36 weeks of folate/methyl deficiency. The endogenous activity of DNA methyltransferase in liver of rats fed with folate/methyl deficient diet for the 36-week period gradually increased with time. In contrast, non-target tissues displayed no changes in DNA methylation level or activity of DNA methyltransferase. The failure of DNA methyltransferase to restore and maintain DNA methylation patterns in preneoplastic liver tissue may lead to the establishment of tumor-specific DNA methylation and DNA methyltransferase profiles that are not expressed in normal liver. These results provide additional information about alterations in DNA methylation during early preneoplastic stages of carcinogenesis. They also demonstrate that DNA hypomethylation is localized to tissue that undergoes carcinogenesis, and is not altered in non-target tissues. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA hypomethylation
KW - DNA methyltransferase
KW - Rat folate/methyl deficiency
N1 - Accession Number: 12745105; Pogribny, Igor P. 1; Email Address: ipogribny@nctr.fda.gov James, S. Jill 2 Jernigan, Stefanie 2 Pogribna, Marta 1; Affiliation: 1: Division of Biochemical Toxicology, FDA-National Center for Toxicological Research, NCTR, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Source Info: Apr2004, Vol. 548 Issue 1/2, p53; Author-Supplied Keyword: DNA hypomethylation; Author-Supplied Keyword: DNA methyltransferase; Author-Supplied Keyword: Rat folate/methyl deficiency; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.12.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kovalchuk, Olga
AU - Burke, Paula
AU - Besplug, Jill
AU - Slovack, Mark
AU - Filkowski, Jody
AU - Pogribny, Igor
T1 - Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/04/14/
VL - 548
IS - 1/2
M3 - Article
SP - 75
SN - 00275107
AB - The biological and genetic effects of chronic low-dose radiation (LDR) exposure and its relationship to carcinogenesis have received a lot of attention in the recent years. For example, radiation-induced genome instability, which is thought to be a precursor of tumorogenesis, was shown to have a transgenerational nature. This indicates a possible involvement of epigenetic mechanisms in LDR-induced genome instability. Genomic DNA methylation is one of the most important epigenetic mechanisms. Existing data on radiation effects on DNA methylation patterns is limited, and no one has specifically studied the effects of the LDR. We report the first study of the effects of whole-body LDR exposure on global genome methylation in muscle and liver tissues of male and female mice. In parallel, we evaluated changes in promoter methylation and expression of the tumor suppressor gene p16INKa and DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT).We observed different patterns of radiation-induced global genome DNA methylation in the liver and muscle of exposed males and females. We also found sex and tissue-specific differences in p16INKa promoter methylation upon LDR exposure. In male liver tissue, p16INKa promoter methylation was more pronounced than in female tissue. In contrast, no significant radiation-induced changes in p16INKa promoter methylation were noted in the muscle tissue of exposed males and females. Radiation also did not significantly affect methylation status of MGMT promoter. We also observed substantial sex differences in acute and chronic radiation-induced expression of p16INKa and MGMT genes. Another important outcome of our study was the fact that chronic low-dose radiation exposure proved to be a more potent inducer of epigenetic effects than the acute exposure. This supports previous findings that chronic exposure leads to greater genome destabilization than acute exposure. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gene expression
KW - Global genome methylation
KW - Ionizing radiation
KW - Low doses
KW - MGMT
KW - p16INKa
KW - Promoter methylation
N1 - Accession Number: 12745107; Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca Burke, Paula 1 Besplug, Jill 1 Slovack, Mark 1 Filkowski, Jody 1 Pogribny, Igor 2; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta., Canada T1K 3M4 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Apr2004, Vol. 548 Issue 1/2, p75; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Global genome methylation; Author-Supplied Keyword: Ionizing radiation; Author-Supplied Keyword: Low doses; Author-Supplied Keyword: MGMT; Author-Supplied Keyword: p16INKa; Author-Supplied Keyword: Promoter methylation; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.12.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106744956
T1 - Screening for obesity in adults: recommendations and rationale.
AU - Calonge N
Y1 - 2004/04/15/
N1 - Accession Number: 106744956. Corporate Author: US Preventive Services Task Force. Language: English. Entry Date: 20040611. Revision Date: 20161128. Publication Type: journal article; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Obesity -- Diagnosis
KW - Obesity -- Prevention and Control
KW - Adult
KW - Body Mass Index
KW - Body Weight
KW - Education, Continuing (Credit)
KW - Medical Practice, Evidence-Based
KW - Preventive Health Care
SP - 1973
EP - 2019
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 69
IS - 8
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - U.S. Preventive Services Task Force: recommendations and rationale series
SN - 0002-838X
AD - Chair, US Preventive Services Task Force, c/o Program Director, USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; uspstf@ahrq.gov
U2 - PMID: 15117019.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Twaddle, Nathan C.
AU - McDaniel, L. Patrice
AU - Gamboa da Costa, Gonçalo
AU - Churchwell, Mona I.
AU - Beland, Frederick A.
AU - Doerge, Daniel R.
AU - Gamboa da Costa, Gonçalo
T1 - Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/04/15/
VL - 207
IS - 1
M3 - journal article
SP - 9
EP - 17
SN - 03043835
AB - Acrylamide (AA) is a well-studied industrial toxicant; however, recent findings of AA at ppm levels in cooked starchy foods have refocused attention on the potential for neurotoxicity, germ cell mutagenicity, and carcinogenicity from AA. Oxidative metabolism of AA to glycidamide (GA) in experimental animals has previously been linked with many toxic effects of AA exposure. We report a new sensitive and selective analytical method, based on LC with electrospray tandem mass spectrometry, for the quantification of AA and GA in serum and its application to a preliminary toxicokinetic evaluation of AA and GA in adult B6C3F1 mice following oral administration of AA. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLAMIDE
KW - MASS spectrometry
KW - POISONS
KW - MICE
KW - OXYGEN -- Metabolism
KW - AMIDES
KW - ANIMAL experimentation
KW - COMPARATIVE studies
KW - DYNAMICS
KW - ETHERS
KW - LIQUID chromatography
KW - MATHEMATICAL models
KW - RESEARCH -- Methodology
KW - MEDICAL cooperation
KW - MUTAGENS
KW - ORAL medication
KW - RATS
KW - RESEARCH
KW - TIME
KW - THEORY
KW - EVALUATION -- Research
KW - Acrylamide
KW - Glycidamide
KW - Mass spectrometry
KW - Toxicokinetics
N1 - Accession Number: 12651657; Twaddle, Nathan C. 1 McDaniel, L. Patrice 1 Gamboa da Costa, Gonçalo 1,2 Churchwell, Mona I. 1 Beland, Frederick A. 1 Doerge, Daniel R. 1; Email Address: ddoerge@nctr.fda.gov Gamboa da Costa, Gonçalo; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 USA 2: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001, Lisboa, Portugal; Source Info: Apr2004, Vol. 207 Issue 1, p9; Subject Term: ACRYLAMIDE; Subject Term: MASS spectrometry; Subject Term: POISONS; Subject Term: MICE; Subject Term: OXYGEN -- Metabolism; Subject Term: AMIDES; Subject Term: ANIMAL experimentation; Subject Term: COMPARATIVE studies; Subject Term: DYNAMICS; Subject Term: ETHERS; Subject Term: LIQUID chromatography; Subject Term: MATHEMATICAL models; Subject Term: RESEARCH -- Methodology; Subject Term: MEDICAL cooperation; Subject Term: MUTAGENS; Subject Term: ORAL medication; Subject Term: RATS; Subject Term: RESEARCH; Subject Term: TIME; Subject Term: THEORY; Subject Term: EVALUATION -- Research; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: Glycidamide; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Toxicokinetics; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: journal article
L3 - 10.1016/j.canlet.2003.10.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahn, Seong-Min
AU - Jeong, Seo-Jin
AU - Kim, Yeon-Soo
AU - Sohn, Yeowon
AU - Moon, Aree
T1 - Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/04/15/
VL - 207
IS - 1
M3 - journal article
SP - 49
EP - 57
SN - 03043835
AB - The matrix metalloproteases (MMPs) play important roles in invasion, metastasis and angiogenesis in various cell types. Tissue inhibitor of metalloprotease (TIMP)-2, an endogenous inhibitor of MMP-2, has been shown to inhibit invasion and metastasis. We have previously shown that MMP-2 is responsible for the H-ras-induced invasive and migrative phenotypes in MCF10A human breast epithelial cells. Here, we investigated the effect of TIMP-2 overexpression on migration and invasion in H-ras MCF10A cells. Human TIMP-2 gene was effectively introduced into H-ras MCF10A cells by retrovirus-mediated gene delivery. TIMP-2 overexpression mediated by retrovirus significantly inhibited migration as well as invasion of H-ras MCF10A cells in a dose-dependent manner. We also show the antiangiogenic effect of TIMP-2 gene delivery. Taken together, our study shows that retrovirus-mediated delivery of TIMP-2 efficiently inhibits metastatic progression of ras-transformed human breast epithelial cells, suggesting a potential use of the TIMP-2 gene therapy for the treatment of breast cancer. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE therapy
KW - RETROVIRUSES
KW - NEOVASCULARIZATION
KW - CANCER genetics
KW - Angiogenesis
KW - Gene therapy
KW - Invasion
KW - Migration
KW - Retrovirus
KW - TIMP-2
N1 - Accession Number: 12651661; Ahn, Seong-Min 1 Jeong, Seo-Jin 1 Kim, Yeon-Soo 2 Sohn, Yeowon 3 Moon, Aree 1; Email Address: armoon@duksung.ac.kr; Affiliation: 1: College of Pharmacy, Duksung Women's University, Seoul 132-714, South Korea 2: Indang Institute of Molecular Biology, Inje University, Seoul 100-032, South Korea 3: Department of Biotechnology, Korea Food and Drug Administration, Seoul 122-020, South Korea; Source Info: Apr2004, Vol. 207 Issue 1, p49; Subject Term: GENE therapy; Subject Term: RETROVIRUSES; Subject Term: NEOVASCULARIZATION; Subject Term: CANCER genetics; Author-Supplied Keyword: Angiogenesis; Author-Supplied Keyword: Gene therapy; Author-Supplied Keyword: Invasion; Author-Supplied Keyword: Migration; Author-Supplied Keyword: Retrovirus; Author-Supplied Keyword: TIMP-2; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: journal article
L3 - 10.1016/j.canlet.2003.11.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chou, Ming W.
AU - Yan, Jian
AU - Nichols, Jasyl
AU - Xia, Qingsu
AU - Beland, Frederick A.
AU - Chan, Po-Cheun
AU - Fu, Peter P.
T1 - Erratum to “Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice” [Cancer Letters 193 (2003) 119–125]
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/04/15/
VL - 207
IS - 1
M3 - Correction notice
SP - 117
SN - 03043835
N1 - Accession Number: 12651670; Chou, Ming W. 1; Email Address: mchou@nctr.fda.gov Yan, Jian 1 Nichols, Jasyl 1 Xia, Qingsu 1 Beland, Frederick A. 1,2 Chan, Po-Cheun 2 Fu, Peter P. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: National Institute of Environmental Health Research, Triangle Park, NC 27709, USA; Source Info: Apr2004, Vol. 207 Issue 1, p117; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.canlet.2003.11.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12651670&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chou, Ming W.
AU - Yan, Jian
AU - Nichols, Jasyl
AU - Xia, Qingsu
AU - Beland, Frederick A.
AU - Chan, Po-Cheun
AU - Fu, Peter P.
T1 - Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice[Cancer Lett. 193 (2003) 119–125]
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/04/15/
VL - 207
IS - 1
M3 - Correction notice
SP - 119
SN - 03043835
AB - Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in male and female F344 rats and male B6C3F1 mice. We previously reported that eight dehydroretronecine (DHR)-derived DNA adducts were formed in liver DNA of rats treated with riddelliine. In order to examine the relationship between DNA adduct levels and the incidence of hemangiosarcomas, we have measured DHR-derived DNA adduct levels in purified rat and mouse liver endothelial cells, the cells of origin for the hemangiosarcomas. F344 rats and B6C3F1 mice were treated by gavage 5 days per week for 2 weeks with riddelliine at 1.0 mg/kg for rats and 3.0 mg/kg for mice. One, 3, 7, and 28 days after the last dose, liver parenchymal and endothelial cell fractions were isolated, and the quantities of DHR-derived DNA adducts were determined by 32P-postlabeling/HPLC. The DHR-derived DNA adduct levels in the endothelial cells were significantly greater than in the parenchymal cells. The DNA adduct levels in rat endothelial cells were greater than in the mouse endothelial cells. These results indicate that the levels of riddelliine-induced DNA adducts in specific populations of liver cells correlate with the preferential induction of liver hemangiosarcomas by riddelliine. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PYRROLIZIDINES
KW - DNA
KW - ALKALOIDS
KW - RATS
KW - DNA adducts
KW - Hemangiosarcomas
KW - Pyrrolizidine alkaloid
KW - Riddelliine
N1 - Accession Number: 12651671; Chou, Ming W. 1; Email Address: mchou@nctr.fda.gov Yan, Jian 1 Nichols, Jasyl 1 Xia, Qingsu 1 Beland, Frederick A. 1 Chan, Po-Cheun 2 Fu, Peter P. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: National Institute of Environmental Health, Research Triangle Park, NC 27709, USA; Source Info: Apr2004, Vol. 207 Issue 1, p119; Subject Term: PYRROLIZIDINES; Subject Term: DNA; Subject Term: ALKALOIDS; Subject Term: RATS; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Hemangiosarcomas; Author-Supplied Keyword: Pyrrolizidine alkaloid; Author-Supplied Keyword: Riddelliine; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Correction notice
L3 - 10.1016/j.canlet.2003.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fleischer, Russell
AU - Boxwell, Debra
AU - Sherman, Kenneth E.
T1 - Nucleoside Analogues and Mitochondrial Toxicity.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/04/15/
VL - 38
IS - 8
M3 - Article
SP - e79
EP - e80
SN - 10584838
AB - An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis. In response, the US product labels for didanosine and ribavirin have been revised to caution clinicians against coadministration of these drugs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - Nucleosides
KW - Acyclovir
KW - Antiviral nucleosides
KW - Mitochondrial pathology
KW - Ribavirin
N1 - Accession Number: 13020575; Fleischer, Russell 1; Email Address: fleischerr@cder.fda.gov; Boxwell, Debra 2; Sherman, Kenneth E. 3; Affiliations: 1: Division of Antiviral Drug Products; 2: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 3: Division of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio; Issue Info: 4/15/2004, Vol. 38 Issue 8, pe79; Thesaurus Term: HIV (Viruses); Subject Term: Nucleosides; Subject Term: Acyclovir; Subject Term: Antiviral nucleosides; Subject Term: Mitochondrial pathology; Subject Term: Ribavirin; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Doublet, Benoît
AU - Carattoli, Alessandra
AU - Whichard, Jean M.
AU - White, David G.
AU - Baucheron, Sylvie
AU - Chaslus-Dancla, Elisabeth
AU - Cloeckaert, Axel
T1 - Plasmid-mediated florfenicol and ceftriaxone resistance encoded by the floR and blaCMY-2 genes in Salmonella enterica serovars Typhimurium and Newport isolated in the United States
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/04/15/
VL - 233
IS - 2
M3 - Article
SP - 301
SN - 03781097
AB - Multidrug resistance plasmids carrying the blaCMY-2 gene have been identified in Salmonella enterica serovars Typhimurium and Newport from the United States. This gene confers decreased susceptibility to ceftriaxone, and is most often found in strains with concomitant resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole and tetracycline. The blaCMY-2-carrying plasmids studied here were shown to also carry the florfenicol resistance gene, floR, on a genetic structure previously identified in Escherichia coli plasmids in Europe. These data indicate that the use of different antimicrobial agents, including phenicols, may serve to maintain multidrug resistance plasmids on which extended-spectrum cephalosporin resistance determinants co-exist with other resistance genes in Salmonella. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Multidrug resistance
KW - Cephalosporins
KW - Plasmids
KW - Conjugation
KW - Phenicols
KW - Plasmid
N1 - Accession Number: 12745020; Doublet, Benoît 1; Carattoli, Alessandra 2; Whichard, Jean M. 3; White, David G. 4; Baucheron, Sylvie 1; Chaslus-Dancla, Elisabeth 1; Cloeckaert, Axel 1; Email Address: cloeckae@tours.inra.fr; Affiliations: 1: Unité BioAgresseurs, Santé, Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France; 2: Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy; 3: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; 4: Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Apr2004, Vol. 233 Issue 2, p301; Thesaurus Term: Salmonella; Subject Term: Multidrug resistance; Subject Term: Cephalosporins; Subject Term: Plasmids; Author-Supplied Keyword: Conjugation; Author-Supplied Keyword: Phenicols; Author-Supplied Keyword: Plasmid; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.femsle.2004.02.023
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Baylor, Melisse Sloas
AU - Johann-Liang, Rosemary
T1 - Hepatotoxicity Associated With Nevirapine Use.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2004/04/15/
VL - 35
IS - 5
M3 - Letter
SP - 538
EP - 539
SN - 15254135
AB - Presents a letter to the editor on hepatotoxicity associated with nevirapine use.
KW - LETTERS to the editor
KW - HEPATOTOXICOLOGY
N1 - Accession Number: 12975963; Baylor, Melisse Sloas 1 Johann-Liang, Rosemary 1; Affiliation: 1: Division of Antiviral Drug Products, US Food and Drug Administration; Source Info: 4/15/2004, Vol. 35 Issue 5, p538; Subject Term: LETTERS to the editor; Subject Term: HEPATOTOXICOLOGY; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Monday, Steven R.
AU - Minnich, Scott A.
AU - Feng, Peter C.H.
T1 - A 12-Base-Pair Deletion in the Flagellar Master Control Gene flhC Causes Nonmotility of the Pathogenic German Sorbitol-Fermenting Escherichia coli O157:H- Strains.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2004/04/15/
VL - 186
IS - 8
M3 - Article
SP - 2319
EP - 2327
SN - 00219193
AB - An atypical, Stx2-producing, pathogenic Escherichia coli O157:H- strain has been isolated with increasing frequency from hemolytic uremic syndrome patients in Germany. The lack of the H7 antigen coupled with the strain's ability to ferment sorbitol and express β-glucuronidase have complicated its detection and identification. In this study, we have determined that the loss of motility in these German sorbitol-fermenting (SF) O157 strains is due to a 12-bp in-frame deletion in flhC that is required for transcriptional activation of genes involved in flagellum biosynthesis. Either complementation with a functional flhC or repair of this mutation restored H7 antigen expression and motility. PCR analysis of several nonmotile E. coli O157 strains from various geographical sources confirmed that the 12-bp flhC deletion is found only in the cluster of German SF O157 strains, providing a potentially useful marker by which these atypical strains can be identified. The loss of motility via mutations in the flhDC operon that we observed in the German SF O157 strains is consistent with a similar phenomenon currently observed in a significant subset of other important gram-negative pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli O157:H7
KW - SORBITOL
KW - PATHOGENIC microorganisms
KW - HEMOLYTIC-uremic syndrome
KW - ANTIGENS
KW - GERMANY
N1 - Accession Number: 13020693; Monday, Steven R. 1 Minnich, Scott A. 2 Feng, Peter C.H. 1; Email Address: pfeng@cfsan.fda.gov; Affiliation: 1: Division of Microbiological Studies, Food and Drug Administration, College Park, Maryland 2: Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho; Source Info: Apr2004, Vol. 186 Issue 8, p2319; Subject Term: ESCHERICHIA coli O157:H7; Subject Term: SORBITOL; Subject Term: PATHOGENIC microorganisms; Subject Term: HEMOLYTIC-uremic syndrome; Subject Term: ANTIGENS; Subject Term: GERMANY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 7 Black and White Photographs, 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1128/JB.186.8.2319-2327.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spann, Kirsten M.
AU - Tran, Kim-C.
AU - Bo Chi
AU - Rabin, Ronald L.
AU - Collins, Peter L.
T1 - Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/04/15/
VL - 78
IS - 8
M3 - Article
SP - 4363
EP - 4369
SN - 0022538X
AB - Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-α/β). However, recombinant HRSV lacking the NSI and NS2 genes (ΔNS½) induced high levels of IFN-α and -β in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary human peripheral blood monocytes. Results with NSI and NS2 single- and double-gene-deletion viruses indicated that the two proteins function independently as well as coordinately to achieve the full inhibitory effect, with NS1 having a greater independent role. The relative contributions of the individual NS proteins were the converse of that recently described for bovine RSV (J. F. Valarcher, J. Furze, S. Wyld, R. Cook, K. K. Conzelmann, and G. Taylor, J. Virol. 77:8426–8439, 2003). This pattern of inhibition by HRSV NS1 and NS2 also extended to the newly described antiviral cytokines IFN-λ1, -2 and -3. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - MEDICAL microbiology
KW - GENETIC vectors
KW - PROTEINS
KW - VIRUS diseases
KW - MEDICAL research
N1 - Accession Number: 13199490; Spann, Kirsten M. 1 Tran, Kim-C. 1 Bo Chi 2 Rabin, Ronald L. 2 Collins, Peter L. 1; Email Address: pcollins@niaid.nih.gov; Affiliation: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 2: Laboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: Apr2004, Vol. 78 Issue 8, p4363; Subject Term: VIRUSES; Subject Term: MEDICAL microbiology; Subject Term: GENETIC vectors; Subject Term: PROTEINS; Subject Term: VIRUS diseases; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.8.4363-4369.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bo Xu
AU - Bhattacharjee, Ashish
AU - Roy, Biswajit
AU - Feldman, Gerald M.
AU - Cathcart, Martha K.
T1 - Role of Protein Kinase C Isoforms in the Regulation of Interleukin-13-induced 15-Lipoxygenase Gene Expression in Human Monocytes.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/04/16/
VL - 279
IS - 16
M3 - Article
SP - 15954
EP - 15960
SN - 00219258
AB - We reported previously that interleukin-13 (IL-13) induces tyrosine phosphorylation/activation of Jak2 and Tyk2 kinases and Stats 1, 3, 5, and 6 in primary human monocytes. We recently revealed that p38 MAPK-mediated serine phosphorylation of both Stat1 and Stat3 is required for the induction of 15-lipoxygenase (15-LO) expression by IL-13. In this study, we present data indicating that another serine/threonine kinase, PKCδ, is also required for IL-13-induced 15-LO expression. PKCδ, a member of the novel protein kinase C (PKC) subclass, was rapidly phosphorylated and activated upon exposure to IL-13. Treatment of cells with rottlerin, a PKCδ inhibitor, blocked IL-13-induced 15-LO mRNA and protein expression, whereas Go6976, an inhibitor of the conventional PKC subclass, had no inhibitory effects. Down-regulation of cellular PKCδ protein levels by PKCδ-specific antisense oligodeoxyribonucleotides also inhibited 15-LO expression markedly. IL-13-induced 15-LO expression resulted in significant inhibition of synthesis of the potent chemotactic factor leukotriene B4, and that process was reversed by rottlerin, presumably through the blockage of PKCδ-dependent 15-LO expression. Furthermore, our data demonstrate that IL-13-mediated activation of PKCδ and p38 MAPK are independent pathways, because inhibition of one kinase activity had no effect on the other, suggesting that the two pathways act in parallel to regulate the downstream targets necessary for 15-LO expression. Inhibition of PKCδ activation by rottlerin also markedly attenuated IL-13-induced Stat3 DNA binding activity. Our findings indicate that PKCδ plays an important role in regulating IL-13-induced 15-LO expression in human monocytes and subsequently modulates the inflammatory responses mediated by 15-LO products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinase C
KW - INTERLEUKINS
KW - LIPOXYGENASES
KW - GENE expression
KW - MONOCYTES
KW - PHOSPHORYLATION
N1 - Accession Number: 13049458; Bo Xu 1 Bhattacharjee, Ashish 1 Roy, Biswajit 1 Feldman, Gerald M. 2 Cathcart, Martha K. 1; Email Address: cathcam@ccf.org; Affiliation: 1: Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 2: Division of Monoclonal Antibodies, Office of Therapeutics, Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: 4/16/2004, Vol. 279 Issue 16, p15954; Subject Term: PROTEIN kinase C; Subject Term: INTERLEUKINS; Subject Term: LIPOXYGENASES; Subject Term: GENE expression; Subject Term: MONOCYTES; Subject Term: PHOSPHORYLATION; Number of Pages: 7p; Illustrations: 4 Diagrams, 5 Graphs; Document Type: Article
L3 - 10.1074/jbc.M400413200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morel, Fabrice
AU - Rauch, Claudine
AU - Petit, Elise
AU - Piton, Amélie
AU - Theret, Nathalie
AU - Coles, Brian
AU - Guillouzo, André
T1 - Gene and Protein Characterization of the Human Glutathione S-Transferase Kappa and Evidence for a Peroxisomal Localization.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/04/16/
VL - 279
IS - 16
M3 - Article
SP - 16246
EP - 16253
SN - 00219258
AB - Kappa class glutathione S-transferase (GST) cDNA sequences have been identified in rat, mouse, and human. In the present study, we determined the structure and chromosomal location of the human GST Kappa 1 (hGSTK1) gene, characterized the protein, and demonstrated its subcellular localization. The human gene spans ∼5 kb, has 8 exons, and maps onto chromosome 7q34. The 5'-flanking region lacks TATA or CCAAT boxes, but there is an initiator element overlapping the transcription start site. hGSTK1 amino acid sequence showed homology to bacterial 2-hydroxychromene-2-carboxylate isomerase, an enzyme involved in naphthalene degradation pathway, hGSTK1 mRNA was expressed in all of the organs examined. Subcellular fractionation of HepG2 cells showed that the protein was located in peroxisomes and mitochondria and was not detectable in cytoplasm. The peroxisomal localization was confirmed by transfection of HepG2 cells with a plasmid coding a green fluorescent protein fused in-frame to the N terminus of hGSTK1. The C terminus of hGSTK1 was essential for localization of the protein to peroxisomes, and the C-terminal sequence Ala-Arg-Leu represents a peroxisome targeting signal. This is the first time that a human GST has been found in peroxisomes, suggesting a new function for this family of enzymes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE transferase
KW - NUCLEOTIDE sequence
KW - PEROXISOMES
KW - AMINO acid sequence
KW - GENETIC transcription
KW - GREEN fluorescent protein
N1 - Accession Number: 13049494; Morel, Fabrice 1; Email Address: Fabrice.More@rennes.inserm.fr Rauch, Claudine 1 Petit, Elise 1 Piton, Amélie 1 Theret, Nathalie 1 Coles, Brian 2 Guillouzo, André 1; Affiliation: 1: INSERM U456, Université de Rennes I, France 2: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas; Source Info: 4/16/2004, Vol. 279 Issue 16, p16246; Subject Term: GLUTATHIONE transferase; Subject Term: NUCLEOTIDE sequence; Subject Term: PEROXISOMES; Subject Term: AMINO acid sequence; Subject Term: GENETIC transcription; Subject Term: GREEN fluorescent protein; Number of Pages: 8p; Illustrations: 6 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M313357200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn
T1 - Commentary: Reinventing continuing medical education.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2004/04/17/
VL - 328
IS - 7445
M3 - Article
SP - E291
EP - E291
SN - 09598146
AB - Presents a commentary on the reinvention of continuing medical education. Details of two significant reports that confirmed large gaps in the quality of American health care; Continuing medical education (CME) as a time-honored but questionable strategy; Importance of systems and practice organizations as critical components of closing the gap in the delivery of evidence-based care; Obstacles in the linking of CME and practice improvements.
KW - MEDICINE -- Study & teaching (Continuing education)
KW - MEDICAL education
KW - CONTINUING education
KW - EVIDENCE-based medicine
KW - HEALTH care reform
KW - MEDICAL care -- United States
KW - UNITED States
N1 - Accession Number: 12826358; Clancy, Carolyn 1; Email Address: cclancy@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Md.; Source Info: 4/17/2004, Vol. 328 Issue 7445, pE291; Subject Term: MEDICINE -- Study & teaching (Continuing education); Subject Term: MEDICAL education; Subject Term: CONTINUING education; Subject Term: EVIDENCE-based medicine; Subject Term: HEALTH care reform; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maier, Andrew
AU - Savage Jr., Russell E.
AU - Haber, Lynne T.
T1 - Assessing Biomarker Use in Risk Assessment--A Survey of Practitioners.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/04/23/
VL - 67
IS - 8-10
M3 - Article
SP - 687
EP - 695
SN - 15287394
AB - Advances in molecular epidemiology and mechanistic toxicology have provided increased opportunities for incorporating biomarkers in the human health risk assessment process. For years, the published literature has lauded the concept of incorporating biomarkers into risk assessments as a means to reduce uncertainty in estimating health risk. For all the potential benefits, one would think that markers of effective dose, markers of early biological effects, and markers of human susceptibility are frequently selected as the basis for quantitative human health risk assessments. For this article, we sought to determine the degree to which this evolution in risk assessment has come to pass. The extent to which biomarkers are being used in current human health risk assessment was determined through an informal survey of leading risk assessment practitioners. Case studies highlighting the evolution of risk assessment methods to include biomarkers are also described. The goal of this review was to enhance the implementation of biomarker technology in risk assessment by (1) highlighting successes in biomarker implementation, (2) identifying key barriers to overcome, and (3) describing evolutions in risk assessment methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - BIOCHEMICAL markers
KW - MOLECULAR epidemiology
KW - TOXICOLOGY
KW - HEALTH risk assessment
KW - ENVIRONMENTAL health
N1 - Accession Number: 12673735; Maier, Andrew 1; Email Address: maier@tera.org Savage Jr., Russell E. 2 Haber, Lynne T. 1; Affiliation: 1: Toxicology Excellence for Risk Assessment, Cincinnati, Ohio, USA 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: 2004, Vol. 67 Issue 8-10, p687; Subject Term: RISK assessment; Subject Term: BIOCHEMICAL markers; Subject Term: MOLECULAR epidemiology; Subject Term: TOXICOLOGY; Subject Term: HEALTH risk assessment; Subject Term: ENVIRONMENTAL health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lentz, T.
AU - Votaw, D.
AU - Ahlers, H.
AU - Hendricks, K.
AU - Pratt, S.
AU - Coleman, P.
AU - Gillen, M.
AU - Ehrenberg, R.
T1 - Occupational Fatalities During Trenching and Excavation Work--United States, 1992--2001.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/04/23/
VL - 53
IS - 15
M3 - Article
SP - 311
EP - 314
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Discusses the results of the analysis of national occupational fatality record and investigative reports of fatal injuries focusing on trenching and excavation work in the U.S. Statistics concerning the death caused by cave-ins and of companies with less than 10 workers; Means to reduce the risk of employees' death; Information on trenching and excavation fatalities in 1992 to 2001; Onsite investigations conducted by researchers with the Fatality Assessment and Control Evaluation program.
KW - OCCUPATIONAL hazards
KW - INDUSTRIAL safety
KW - WORK-related injuries
KW - EXCAVATION
KW - STATISTICS
KW - UNITED States
N1 - Accession Number: 13015414; Lentz, T. 1 Votaw, D. 1 Ahlers, H. 1 Hendricks, K. 2 Pratt, S. 2 Coleman, P. 3 Gillen, M. 4 Ehrenberg, R. 4; Affiliation: 1: Education and Information Div., National Institute for Occupational Safety and Health, CDC 2: Div of Safety Research, National Institute for Occupational Safety and Health, CDC 3: Spokane Research Laboratory, National Institute for Occupational Safety and Health, CDC 4: Office of the Director, National Institute for Occupational Safety and Health, CDC; Source Info: 4/23/2004, Vol. 53 Issue 15, p311; Subject Term: OCCUPATIONAL hazards; Subject Term: INDUSTRIAL safety; Subject Term: WORK-related injuries; Subject Term: EXCAVATION; Subject Term: STATISTICS; Subject Term: UNITED States; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 4p; Illustrations: 1 Color Photograph, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, P.
AU - Ward, M.
AU - Baron, R. L.
AU - Humble, W.
AU - Hadzihasanovic, M.
AU - Cox, R.
AU - Tapp, L.
AU - McCammon, J.
AU - McCleery, R.
T1 - Carbon Monoxide Poisonings Resulting from Open Air Exposures to Operating Motorboats -- Lake Havasu City, Arizona, 2003.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/04/23/
VL - 53
IS - 15
M3 - Article
SP - 314
EP - 318
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the findings of environmental surveys to assess carbon monoxide (CO) exposure in Bridgewater Channel of Lake Havasu in Arizona. Fatal and non-fatal cases of CO poisoning which occurred in vacationers who were boating near the Bridgewater Channel of Lake Havasu in Arizona within February 1997 to August 2002; Prevalence of reported post-shift symptoms among municipal employees; Concentration of CO obtained through ambient air monitoring.
KW - CARBON dioxide -- Physiological effect
KW - AIR analysis
KW - OCCUPATIONAL hazards
KW - EMPLOYEES
KW - SYMPTOMS
KW - HAVASU, Lake (Ariz. & Calif.)
KW - ARIZONA
KW - UNITED States
N1 - Accession Number: 13015454; Roberts, P. 1 Ward, M. 2 Baron, R. L. 3 Humble, W. 4 Hadzihasanovic, M. 4 Cox, R. 4 Tapp, L. 5 McCammon, J. 5 McCleery, R. 5; Affiliation: 1: Sonoma Technology, Inc., Petaluma, California 2: Havasu Regional Medical Center Emergency Dept, Lake Havasu City 3: Banner Good Samaritan Regional Medical Center Emergency Dept, Phoenix 4: Office of Environmental Health, Arizona Dept of Health Svcs. 5: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 4/23/2004, Vol. 53 Issue 15, p314; Subject Term: CARBON dioxide -- Physiological effect; Subject Term: AIR analysis; Subject Term: OCCUPATIONAL hazards; Subject Term: EMPLOYEES; Subject Term: SYMPTOMS; Subject Term: HAVASU, Lake (Ariz. & Calif.); Subject Term: ARIZONA; Subject Term: UNITED States; Number of Pages: 4p; Illustrations: 1 Color Photograph, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Struttmann, T. W.
AU - Marsh, S. W.
T1 - Work-Related Pilot Fatalities in Agriculture-- United States, 1992--2001.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/04/23/
VL - 53
IS - 15
M3 - Article
SP - 318
EP - 320
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the results of the analysis of data on fatal injuries to pilots working in the U.S. agriculture industry from 1992 to 2001. Comparison of risk for fatal injury between agricultural pilots with pilots in other industries; Efforts of the agriculture aviation profession regarding reducing fatalities; Statistics concerning pilot/navigator fatalities in agriculture; Causes of aircraft crashes.
KW - AIRCRAFT accidents
KW - AGRICULTURE -- United States
KW - PILOTS & pilotage
KW - OCCUPATIONAL hazards
KW - UNITED States
N1 - Accession Number: 13015460; Struttmann, T. W. 1 Marsh, S. W. 1; Affiliation: 1: Div of Safety Research, National Institute for Occupational Safety and Health, CDC; Source Info: 4/23/2004, Vol. 53 Issue 15, p318; Subject Term: AIRCRAFT accidents; Subject Term: AGRICULTURE -- United States; Subject Term: PILOTS & pilotage; Subject Term: OCCUPATIONAL hazards; Subject Term: UNITED States; NAICS/Industry Codes: 488330 Navigational Services to Shipping; NAICS/Industry Codes: 488332 Ship piloting services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yue, Hongfei
AU - Strauss, Kenneth I.
AU - Borenstein, Michael R.
AU - Barbe, Mary F.
AU - Rossi, Luella J.
AU - Jansen, Susan A.
T1 - Determination of bioactive eicosanoids in brain tissue by a sensitive reversed-phase liquid chromatographic method with fluorescence detection
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2004/04/25/
VL - 803
IS - 2
M3 - Article
SP - 267
SN - 15700232
AB - Arachidonic acid (AA) is metabolized to prostaglandins (PGs) via cyclooxygenases (COX) catalysis, and to epoxyeicosatrienoic acids (EETs), dihydroxyeicosatrienoic acids (DiHETrEs), and hydroxyeicosatetraenoic acids (HETEs) via cytochrome P450 (CYP450) enzymes. A reliable and robust fluorescence based HPLC method for these eicosanoids was developed. A new selective reverse-phase solid phase extraction (SPE) procedure was developed for PG, DiHETrEs, HETE, and EETs of interest from rat cortical brain tissue. The eicosanoids were derivatized with 2-(2,3-naphthalimino)ethyl-trifluoromethanesulphonate (NE-OTf), followed by separation and quantification at high sensitivity using reverse-phase HPLC with fluorescent detection, and further identified via LC/MS. The derivatization was studied and optimized to obtain reproducible reactions. Various PGs, DiHETrEs, HETEs, EETs, and AA were sensitively detected and baseline resolved simultaneously. LC/MS under positive electrospray ionization selected ion monitoring (SIM) mode was developed to further identify the peaks of these eicosanoids in cortical brain tissue. The method was applied in the traumatic brain injured rat brain. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EICOSANOIC acid -- Derivatives
KW - ARACHIDONIC acid
KW - PROSTAGLANDINS
KW - CYCLOOXYGENASES
KW - CYTOCHROMES
KW - Eicosanoids
N1 - Accession Number: 12739452; Yue, Hongfei 1 Strauss, Kenneth I. 2 Borenstein, Michael R. 3 Barbe, Mary F. 4 Rossi, Luella J. 5 Jansen, Susan A. 1; Email Address: suebee@unix.temple.edu; Affiliation: 1: Chemistry Department, Analytical Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA 2: Department of Neurosurgery, College of Medicine, University of Cincinnati, ML515, 231 Albert Sabin Way, Cincinnati, OH 45267-0515, USA 3: School of Pharmacy, Temple University, 3307 N. Broad Street, Philadelphia, PA 19140, USA 4: Departments of Physical Therapy; Anatomy and Cell Biology, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA 5: US Food and Drug Administration, 2nd and Chestnut Street, Philadelphia, PA 19106, USA; Source Info: Apr2004, Vol. 803 Issue 2, p267; Subject Term: EICOSANOIC acid -- Derivatives; Subject Term: ARACHIDONIC acid; Subject Term: PROSTAGLANDINS; Subject Term: CYCLOOXYGENASES; Subject Term: CYTOCHROMES; Author-Supplied Keyword: Eicosanoids; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jchromb.2003.12.027
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gamache, R. M.
AU - Drotar, J. T.
AU - Lee, R. J.
AU - Callahan, J. H.
AU - Evans, T. W.
AU - Turner, N. H.
T1 - Study of Secondary Reactions from Explosives Detonated within a Bombproof and Shock Tube System via Visible Spectrometry and Gas and Solids Collection.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2004/04/26/
VL - 706
IS - 1
M3 - Article
SP - 843
EP - 846
PB - American Institute of Physics
SN - 0094243X
AB - An investigation into the secondary reactions of 5 selected explosives of nominally 2.3 lb and 5 lb charges has been performed. To investigate points of ignition and chemical potential for a secondary energy release, the following instrumentation was incorporated: total light output, visible spectrometry, blast pressure measurement, and gas and solids collection. Two internal blast structures were investigated: a 20 ft square bombproof room (ceiling height 16 ft) (only 2.3 lb charges were detonated within bombproof) and a 100 ft long × 4 ft diameter explosive shock tube. A comparison in performance of explosives detonated within both bombproof and shock tube displayed different results. Within the bombproof, after detonation but prior to initial wall impact, collected gas and solids displayed a large percentage of unburned fuels. After wall impact, the unburned fuel within the gas was greatly reduced. Collection within the shock tube at the first collection station, 9 ft from the point of detonation, displayed almost no unburned fuel (both gas and solids). Real time light emission and blast pressure measurements were correlated with collected gas and solids data. © 2004 American Institute of Physics [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXPLOSIVES
KW - SHOCK tubes
KW - BALLISTIC ranges
KW - SHOCK (Mechanics)
KW - SHOCK waves
KW - DETONATION waves
KW - BOMBPROOF building
N1 - Accession Number: 14019975; Gamache, R. M. 1 Drotar, J. T. 1 Lee, R. J. 2 Callahan, J. H. 3,4 Evans, T. W. 3 Turner, N. H. 3; Affiliation: 1: Warheads Branch, Naval Surface Warfare Center Dahlgren, Dahlgren, VA 22448 2: Research and Technology Dept., Naval Surface Warfare Center Indian Head, Indian Head, MD 20640 3: Code 6113, Naval Research Laboratory, Washington, DC 20375 4: U.S. Food and Drug Administration, College Park, MD 20740; Source Info: 2004, Vol. 706 Issue 1, p843; Subject Term: EXPLOSIVES; Subject Term: SHOCK tubes; Subject Term: BALLISTIC ranges; Subject Term: SHOCK (Mechanics); Subject Term: SHOCK waves; Subject Term: DETONATION waves; Subject Term: BOMBPROOF building; NAICS/Industry Codes: 325920 Explosives Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1063/1.1780368
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Macher, Abe M.
AU - Kibble, Deborah
AU - Schuster-Walker, Marmie
T1 - Retroviral Rebound Syndrome.
JO - American Jails
JF - American Jails
Y1 - 2004/05//May/Jun2004
VL - 18
IS - 2
M3 - Article
SP - 37
EP - 39
SN - 10560319
AB - Discusses the retroviral rebound syndrome in U.S. correctional HIV care. Case studies of inmates with retroviral rebound syndrome; Factors affecting the unnecessary interruption of patients' antiretroviral therapy; Need for correctional health services administrators to coordinate and monitor antiretroviral therapy continuity to prevent unnecessary patient morbidity.
KW - HIV infections
KW - PRISONERS -- Medical care
KW - ANTIRETROVIRAL agents
KW - HIV-positive persons
KW - CORRECTIONAL institutions
KW - UNITED States
N1 - Accession Number: 13334982; Macher, Abe M. 1 Kibble, Deborah 2 Schuster-Walker, Marmie 3; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Public Health Service, Rockville, Maryland 2: nursing supervisor, Prince William-Manassas Regional Adult Detention Center, Manassas, Virginia 3: Chronic Care Nurse, Prince William-Manassas Regional Adult Detention Center, Manassas, Virginia; Source Info: May/Jun2004, Vol. 18 Issue 2, p37; Subject Term: HIV infections; Subject Term: PRISONERS -- Medical care; Subject Term: ANTIRETROVIRAL agents; Subject Term: HIV-positive persons; Subject Term: CORRECTIONAL institutions; Subject Term: UNITED States; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 922140 Correctional Institutions; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106745891
T1 - First, do no harm. Avoiding the near misses: taking into account one ever-present factor: human fallibility.
AU - Hughes RG
Y1 - 2004/05//
N1 - Accession Number: 106745891. Language: English. Entry Date: 20040618. Revision Date: 20150819. Publication Type: Journal Article; review; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Patient Safety
KW - Quality Assurance
KW - Risk Management
KW - Incident Reports
KW - Organizational Culture
KW - Personnel Staffing and Scheduling
KW - Simulations
KW - Staff Development
KW - Stress, Occupational
SP - 81
EP - 84
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 104
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Senior Health Science Administrator and Senior Advisor for End-of-Life, Agency for Healthcare Research and Quality; rhughes@ahrq.gov
U2 - PMID: 15166731.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roy, S.
AU - Caillouette, J.C.
AU - Roy, T.
AU - Faden, J.S.
T1 - Vaginal pH is similar to follicle-stimulating hormone for menopause diagnosis.
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2004/05//
VL - 190
IS - 5
M3 - Article
SP - 1272
EP - 1277
SN - 00029378
AB - Objective: This paper is intended to demonstrate whether vaginal pH value is associated with menopausal status and symptoms, to review the sensitivity of follicle-stimulating hormone or vaginal pH to diagnose menopause, to compare these findings to a group of practice patients, and to determine whether vaginal pH could be used in place of follicle-stimulating hormone as an initial screen to determine menopause. Study design: Sixteen studies regarding vaginal pH and menopausal symptoms before and after estrogen administration were analyzed. Two epidemiologic studies that reported follicle-stimulating hormone or vaginal pH with menopause were reviewed. These findings were compared with similar data from the practice of one of the authors (J.C.C.). Results: Menopausal women who do not receive estrogen therapy have a weighted average vaginal pH of 6.0, which is reduced significantly to 4.5 with estrogen therapy. To diagnose menopause, follicle-stimulating hormone ≥15 or ≥20 mu/mL in the Third National Health and Nutrition Examination Survey had a sensitivity of 65% to 68%. In a study in Costa Rica, where 3 definitions of menopause were used, a pH of >5.0 had a sensitivity of 64% to 67%. From the practice patients, the 95% confidence interval sensitivities and positive predictive values of vaginal pH and follicle-stimulating hormone to diagnose menopause overlapped, while a pH≤4.5 indicated mid follicular phase estradiol levels. Conclusion: In women without vaginitis and no estrogen therapy, a vaginal pH of >4.5 indicates menopause, because it demonstrates a similar sensitivity as follicle-stimulating hormone in epidemiologic studies. In the practice patients, the sensitivity of follicle-stimulating hormone was no different than vaginal pH in the diagnosis of menopause. Furthermore, with estrogen therapy, a vaginal pH of ≤4.5 indicates a mid follicular phase estradiol. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROGEN-ion concentration
KW - VAGINA
KW - FEMALE reproductive organs
KW - FOLLICLE-stimulating hormone
KW - GONADOTROPIN
KW - MENOPAUSE
KW - Follicle-stimulating hormone
KW - Menopause
KW - Vaginal pH value
N1 - Accession Number: 13587499; Roy, S. 1; Email Address: subirro@usc.edu; Caillouette, J.C. 1; Roy, T.; Faden, J.S. 2; Source Information: May2004, Vol. 190 Issue 5, p1272; Subject: HYDROGEN-ion concentration; Subject: VAGINA; Subject: FEMALE reproductive organs; Subject: FOLLICLE-stimulating hormone; Subject: GONADOTROPIN; Subject: MENOPAUSE; Author-Supplied Keyword: Follicle-stimulating hormone; Author-Supplied Keyword: Menopause; Author-Supplied Keyword: Vaginal pH value; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1016/j.ajog.2003.12.015
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Warren, Gordon L.
AU - O'Farrell, Laura
AU - Summan, Mukesh
AU - Hulderman, Tracy
AU - Mishra, Dawn
AU - Luster, Michael I.
AU - Kuziel, William A.
AU - Simeonova, Petia P.
T1 - Role of CC chemokines in skeletal muscle functional restoration after injury.
JO - American Journal of Physiology: Cell Physiology
JF - American Journal of Physiology: Cell Physiology
Y1 - 2004/05//
VL - 55
IS - 5
M3 - Article
SP - C1031
EP - C1036
SN - 03636143
AB - The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1α, MIP-1β, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradually returned to control (uninjured) levels by 14 days. Muscle function and histological characteristics were monitored in injured mice that were genetically deficient for the CCR5 receptor (a major receptor for MIP-1α and MIP-1β) and also rendered MCP-1 deficient with neutralizing antibodies. To dissect the role of these chemokines, additional studies were conducted in CCR5- and CCR2-deficient mice. CCR5-/- mice injected with MCP-1 antiserum for the first 3 days after injury exhibited a twofold greater maximal isometric tetanic torque deficit at 14 days after injury than did controls (i.e., 33% vs. 17%; P = 0.002). The impaired functional recovery was accompanied with an increased fat infiltration within the regenerating muscle without a significant difference in the influx of inflammatory cells, including macrophages. Strength recovery was also impaired in mice deficient for the receptor of MCP-1, CCR2, but not in CCR5-/mice that were not injected with MCP-1 antiserum. The data suggest that MCP-1/CCR2 plays a role in the regeneration and recovery of function after traumatic muscle injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Cell Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMOKINES
KW - INFLAMMATION
KW - REGENERATION (Biology)
KW - IMMUNOGLOBULINS
KW - MONOCYTES
KW - MACROPHAGES
KW - chemokine receptors
KW - inflammation
KW - regeneration
N1 - Accession Number: 13017007; Warren, Gordon L. 1 O'Farrell, Laura 1 Summan, Mukesh 2 Hulderman, Tracy 2 Mishra, Dawn 2 Luster, Michael I. 2 Kuziel, William A. 3 Simeonova, Petia P. 2; Email Address: psimeonova@cdc.gov; Affiliation: 1: Department of Physical Therapy, Georgia State University, Atlanta, Georgia 30303 2: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 3: Autoinmmune and Inflammatory Diseases, Protein Design Labs, Fremont, California 94555; Source Info: May2004, Vol. 55 Issue 5, pC1031; Subject Term: CHEMOKINES; Subject Term: INFLAMMATION; Subject Term: REGENERATION (Biology); Subject Term: IMMUNOGLOBULINS; Subject Term: MONOCYTES; Subject Term: MACROPHAGES; Author-Supplied Keyword: chemokine receptors; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: regeneration; Number of Pages: 6p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1152/ajpcell.00467.2003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manski, Richard J.
AU - Goodman, Harold S.
AU - Reid, Britt C.
AU - Macek, Mark D.
T1 - Dental Insurance Visits and Expenditures Among Older Adults.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/05//
VL - 94
IS - 5
M3 - Article
SP - 759
EP - 764
PB - American Public Health Association
SN - 00900036
AB - Objectives. We examined the effect of age, income, and coverage on dental service utilization during 1996. Methods. We used data from the 1996 Medical Expenditure Panel Survey. Results. Edentulous and poorer older adults are less likely to have coverage and less likely to report a dental visit than dentate or wealthier older adults. Conclusions. These analyses help to describe the needs of older adults as they cope with diminishing resources as a consequence of retirement, including persons previously accustomed to accessing oral health services with dental insurance. (Am J Public Health. 2004;94:759-764). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - DENTAL insurance
KW - MEDICAL care
KW - MEDICAL care costs
KW - OLDER people -- Health
N1 - Accession Number: 12988701; Manski, Richard J. 1,2; Email Address: manski@dental.umaryland.edu Goodman, Harold S. 1 Reid, Britt C. 1 Macek, Mark D. 1; Affiliation: 1: Department of Health Promotion and Policy, University of Maryland School of Dentistry, Baltimore 2: Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Md.; Source Info: May2004, Vol. 94 Issue 5, p759; Subject Term: DENTAL care; Subject Term: DENTAL insurance; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs; Subject Term: OLDER people -- Health; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article; Full Text Word Count: 5383
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106633789
T1 - Regulatory toxicology perspective on the development of botanical drug products in the United States.
AU - Wu K
AU - Farrelly J
AU - Birnkrant D
AU - Chen S
AU - Dou J
AU - Atrakchi A
AU - Bigger A
AU - Chen C
AU - Chen Z
AU - Freed L
AU - Ghantous H
AU - Goheer A
AU - Hausner E
AU - Osterberg R
AU - Rhee H
AU - Zhang K
Y1 - 2004/05//
N1 - Accession Number: 106633789. Language: English. Entry Date: 20050513. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9441347.
KW - Drug Design -- Legislation and Jurisprudence
KW - Plants, Medicinal -- Legislation and Jurisprudence
KW - Rules and Regulations
KW - Toxicology
KW - United States
SP - 213
EP - 217
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
JA - AM J THER
VL - 11
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Toxicological studies constitute an essential part of the effort in developing a botanical supplement into a drug product. The US Food and Drug Administration recently published a draft guidance and established a special botanical review team to assist academic and industry sponsors to manage this and other regulatory considerations related to this unique group of drug products. In this article, the current state of regulatory viewpoints on issues related to requirements and recommendations of various types of nonclinical toxicity studies in support of advanced phases clinical trials and filing a New Drug Application of a botanical are discussed. Topics include nonclinical pharmacology/toxicology view of previous human experience and initial clinical trial, regulatory perspectives on acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive 2-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated.
SN - 1075-2765
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD
U2 - PMID: 15133537.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106604211
T1 - Clinical use of immunoassays in assessing exposure to fungi and potential health effects related to fungal exposure.
AU - Trout DB
AU - Seltzer JM
AU - Page EH
AU - Biagini RE
AU - Schmechel D
AU - Lewis DM
AU - Boudreau AY
Y1 - 2004/05//2004 May
N1 - Accession Number: 106604211. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9503580.
KW - Environmental Exposure
KW - Environmental Microbiology
KW - Fungi
KW - Hypersensitivity, Immediate
KW - Immunoassay
KW - Mycoses -- Diagnosis
KW - Mycoses -- Immunology
KW - Education, Continuing (Credit)
SP - 483
EP - 575
JO - Annals of Allergy, Asthma & Immunology
JF - Annals of Allergy, Asthma & Immunology
JA - ANN ALLERGY ASTHMA IMMUNOL
VL - 92
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To review and summarize current evidence regarding the proper role of immunoassays in clinical assessments of exposure to fungi and health effects related to fungal exposure. DATA SOURCES: We reviewed relevant scientific investigations and previously published reviews concerning this topic. STUDY SELECTION: The authors' clinical, laboratory, and public health experiences were used to evaluate relevant data for scientific merit. RESULTS: Testing to determine the presence of IgE to specific fungi may be a useful component of a complete clinical evaluation in the diagnosis of illnesses that can be caused by immediate hypersensitivity such as allergic rhinitis and asthma. Detection of IgG to specific fungi has been used as a marker of exposure to agents that may cause illnesses such as hypersensitivity pneumonitis. However, the ubiquitous nature of many fungi and the lack of specificity of fungal antigens limit the usefulness of these types of tests in the evaluation of potential building-related illness and fungal exposure. Specific serologic tests (such as tests for cryptococcal antigen, coccidioidal antibody, and Histoplasma antigen) have been shown to be useful in the diagnosis of some fungal infections, but these are the exception not the rule. CONCLUSIONS: There is currently not enough scientific evidence to support the routine clinical use of immunoassays as a primary means of assessing environmental fungal exposure or health effects related to fungal exposure. Health care providers who care for persons expressing concerns about the relationship of symptoms to potential exposure to fungi are advised to use immunoassay results with care and only as an adjunct to a comprehensive approach to patient care.
SN - 1081-1206
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, 4676 Columbia Pkwy, MS R-10, Cincinnati, OH 45226-1998; dtrout@cdc.gov
U2 - PMID: 15191015.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Calonge, Ned
T1 - Screening for Ovarian Cancer: Recommendation Statement.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2004/05//May/Jun2004
VL - 2
IS - 3
M3 - Article
SP - 260
EP - 262
PB - Annals of Family Medicine
SN - 15441709
AB - Summarizes the current U.S. Preventive Services Task Force recommendation on screening for ovarian cancer. Nature of diagnostic testing after a positive screening test; Addition of color Doppler imaging to ultrasound screening; Risk factors associated with ovarian cancer.
KW - MEDICAL screening
KW - DIAGNOSIS
KW - OVARIAN diseases
KW - CANCER -- Risk factors
KW - DOPPLER ultrasonography
KW - DIAGNOSTIC imaging
KW - UNITED States
KW - mass screening
KW - Ovarian neoplasms
KW - practice guidelines
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 14071815; Calonge, Ned 1; Email Address: auspstf@ahrq.gov; Affiliation: 1: Chair, US Preventive Services Task Force c/o Program Director, USPSTF, Agency for Healthcare Research and Quality 540 Gaither Road, Rockville, MD 20850; Source Info: May/Jun2004, Vol. 2 Issue 3, p260; Subject Term: MEDICAL screening; Subject Term: DIAGNOSIS; Subject Term: OVARIAN diseases; Subject Term: CANCER -- Risk factors; Subject Term: DOPPLER ultrasonography; Subject Term: DIAGNOSTIC imaging; Subject Term: UNITED States; Author-Supplied Keyword: mass screening; Author-Supplied Keyword: Ovarian neoplasms; Author-Supplied Keyword: practice guidelines; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
L3 - 10.1370/afm.200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calonge, Ned
T1 - Screening for Visual Impairment in Children Younger Than Age 5 Years: Recommendation Statement.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2004/05//May/Jun2004
VL - 2
IS - 3
M3 - Article
SP - 263
EP - 266
PB - Annals of Family Medicine
SN - 15441709
AB - Summarizes the U.S. Preventive Services Task Force recommendation on screening for visual impairment in children younger than age 5 years. Improvement of visual acuity; Association of intense screening by eye professionals with decrease in the prevalence of amblyopia; Accuracy of vision screening tests in children.
KW - EYE -- Examination
KW - EYE -- Diseases
KW - AMBLYOPIA
KW - VISION disorders in children
KW - VISUAL acuity
KW - U.S. Preventive Services Task Force
KW - UNITED States
KW - Amblyopia
KW - mass screening
KW - practice guidelines
N1 - Accession Number: 14071871; Calonge, Ned 1; Email Address: uspstf@ahrq.gov; Source Information: May/Jun2004, Vol. 2 Issue 3, p263; Subject: EYE -- Examination; Subject: EYE -- Diseases; Subject: AMBLYOPIA; Subject: VISION disorders in children; Subject: VISUAL acuity; Subject: U.S. Preventive Services Task Force; Geographic Terms: UNITED States; Author-Supplied Keyword: Amblyopia; Author-Supplied Keyword: mass screening; Author-Supplied Keyword: practice guidelines; Number of Pages: 4p; Document Type: Article
L3 - 10.1370/afm.193
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Adam M. Huber
AU - Brian M. Feldman
AU - Robert M. Rennebohm
AU - Jeanne E. Hicks
AU - Carol B. Lindsley
AU - Maria D. Perez
AU - Lawrence S. Zemel
AU - Carol A. Wallace
AU - Susan H. Ballinger
AU - Murray H. Passo
AU - Ann M. Reed
AU - Ronald M. Summers
AU - Patience H. White
AU - Ildy M. Katona
AU - Frederick W. Miller
AU - Peter A. Lachenbruch
AU - Lisa G. Rider
T1 - Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2004/05//
VL - 50
IS - 5
M3 - Article
SP - 1595
EP - 1603
SN - 00043591
AB - To examine the measurement characteristics of the Childhood Myositis Assessment Scale (CMAS) in children with juvenile idiopathic inflammatory myopathy (juvenile IIM), and to obtain preliminary data on the clinical significance of CMAS scores. One hundred eight children with juvenile IIM were evaluated on 2 occasions, 79 months apart, using various measures of physical function, strength, and disease activity. Interrater reliability, construct validity, and responsiveness of the CMAS were examined. The minimum clinically important difference (MID) and CMAS scores corresponding to various degrees of physical disability were estimated. The intraclass correlation coefficient for 26 patients assessed by 2 examiners was 0.89, indicating very good interrater reliability. The CMAS score correlated highly with the Childhood Health Assessment Questionnaire (C-HAQ) score and with findings on manual muscle testing (MMT) (rs = −0.73 and 0.73, respectively) and moderately with physician-assessed global disease activity and skin activity, parent-assessed global disease severity, and muscle magnetic resonance imaging (rs = −0.44 to −0.61), thereby demonstrating good construct validity. The standardized response mean was 0.81 (95% confidence interval 0.53, 1.09) in patients with at least 0.8 cm improvement on a 10-cm visual analog scale for physician-assessed global disease activity, indicating strong responsiveness. In bivariate regression models predicting physician-assessed global disease activity, MMT remained significant in models containing the CMAS (P = 0.03) while the C-HAQ did not (P = 0.4). Estimates of the MID ranged from 1.5 to 3.0 points on a 052-point scale. CMAS scores corresponding to no, mild, mild-to-moderate, and moderate physical disability, respectively, were 48, 45, 39, and 30. The CMAS exhibits good reliability, construct validity, and responsiveness, and is therefore a valid instrument for the assessment of physical function, muscle strength, and endurance in children with juvenile IIM. Preliminary data on MID and corresponding levels of disability should aid in the clinical interpretation of CMAS scores when assessing patients with juvenile IIM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYOSITIS
KW - MUSCLES -- Diseases
KW - PATIENTS
KW - DIAGNOSTIC imaging
KW - MAGNETIC resonance imaging
KW - MUSCLE strength
KW - DISABILITY evaluation
N1 - Accession Number: 20685502; Adam M. Huber 1 Brian M. Feldman 2 Robert M. Rennebohm 3 Jeanne E. Hicks 4 Carol B. Lindsley 5 Maria D. Perez 6 Lawrence S. Zemel 7 Carol A. Wallace 8 Susan H. Ballinger 9 Murray H. Passo 10 Ann M. Reed 11 Ronald M. Summers 4 Patience H. White 12 Ildy M. Katona 13 Frederick W. Miller 14 Peter A. Lachenbruch 15 Lisa G. Rider 14; Affiliation: 1: IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada 2: Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada 3: Columbus Children's Hospital and Ohio State University, Columbus 4: Clinical Center, NIH, Bethesda, Maryland 5: University of Kansas, Kansas City 6: Texas Children's Hospital and Baylor College of Medicine, Houston 7: Connecticut Children's Medical Center and University of Connecticut, Hartford 8: Children's Hospital and University of Washington, Seattle 9: Riley Children's Hospital and University of Indiana, Indianapolis 10: Children's Hospital and University of Cincinnati, Cincinnati, Ohio 11: Mayo Clinic, Rochester, Minnesota 12: Children's National Medical Center, Washington, DC 13: Uniformed Services University of the Health Sciences, Bethesda, Maryland 14: National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 15: Center for Biologics Evaluation and Research, FDA, Rockville, Maryland; Source Info: May2004, Vol. 50 Issue 5, p1595; Subject Term: MYOSITIS; Subject Term: MUSCLES -- Diseases; Subject Term: PATIENTS; Subject Term: DIAGNOSTIC imaging; Subject Term: MAGNETIC resonance imaging; Subject Term: MUSCLE strength; Subject Term: DISABILITY evaluation; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li Dong
AU - Shu-ichi Ito
AU - Ken J. Ishii
AU - Dennis M. Klinman
T1 - Suppressive oligonucleotides protect against collagen-induced arthritis in mice.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2004/05//
VL - 50
IS - 5
M3 - Article
SP - 1686
EP - 1689
SN - 00043591
AB - To examine whether systemic administration of oligonucleotides (ODNs), known to inhibit the production of proinflammatory cytokines, alters host susceptibility to collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA). CIA was induced by injecting DBA/1 mice with type II collagen (CII) in Freund's complete adjuvant, followed 3 weeks later by CII in Freund's incomplete adjuvant. The effect of suppressive ODNs on the incidence and severity of disease was monitored, as were immune correlates of CIA. Suppressive ODNs administered during the inductive phase of CIA significantly reduced the incidence and severity of arthritis. Treatment with suppressive ODNs significantly decreased serum titers of pathogenic IgG anti-CII autoantibodies and interferon-γ production by collagen-reactive T cells. Suppressive ODNs may be of therapeutic value in the treatment of RA, and potentially other autoimmune diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTHRITIS
KW - JOINTS (Anatomy) -- Diseases
KW - RHEUMATOID arthritis
KW - CYTOKINES
KW - IMMUNE response -- Regulation
KW - OLIGONUCLEOTIDES -- Therapeutic use
KW - EXTRACELLULAR matrix proteins
KW - IMMUNOLOGICAL adjuvants
KW - AUTOIMMUNE diseases
KW - ANTINEOPLASTIC agents
KW - ANTIVIRAL agents
KW - T cells
N1 - Accession Number: 20685531; Li Dong 1 Shu-ichi Ito 1 Ken J. Ishii 1 Dennis M. Klinman 1; Affiliation: 1: US Food and Drug Administration, Bethesda, Maryland; Source Info: May2004, Vol. 50 Issue 5, p1686; Subject Term: ARTHRITIS; Subject Term: JOINTS (Anatomy) -- Diseases; Subject Term: RHEUMATOID arthritis; Subject Term: CYTOKINES; Subject Term: IMMUNE response -- Regulation; Subject Term: OLIGONUCLEOTIDES -- Therapeutic use; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: AUTOIMMUNE diseases; Subject Term: ANTINEOPLASTIC agents; Subject Term: ANTIVIRAL agents; Subject Term: T cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chera, Bhisham
AU - Schaecher, Kurt E.
AU - Rocchini, Anne
AU - Imam, Syed Z.
AU - Sribnick, Eric A.
AU - Ray, Swapan K.
AU - Ali, Syed F.
AU - Banik, Naren L.
T1 - Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice
JO - Brain Research
JF - Brain Research
Y1 - 2004/05//
VL - 1006
IS - 2
M3 - Article
SP - 150
SN - 00068993
AB - Parkinson''s disease (PD) is a movement disorder characterized by rigidity, tremor, and bradykinesia, originating from degeneration of dopaminergic neurons in the substantia nigra (SN), retrorubral area, and locus ceoruleus (LC). Calpain has been implicated in the pathophysiology of neurodegenerative diseases. Since the spinal cord (SC) and brain are integrally connected and calpain is involved in cell death and mitochondrial dysfunction, we hypothesized that SC neurons are also affected in PD. In order to examine this hypothesis, we examined both brain and SC from mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To identify cells expressing calpain, double immunofluorescent labeling was performed with antibodies specific for calpain and a cell type (OX-42, GFAP, or NeuN). Combined terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) and double immunofluorescent labeling were used to identify death of specific cells in the central nervous system (CNS). There was an increase in calpain expression in microglia, astrocytes, and neurons in the SC of MPTP-treated mice at 1 and 7 days, as compared to controls. TUNEL-positive neurons in the SC and SN showed apoptotic characteristics. These results demonstrated that neuronal death occurred not only in SN but also in the SC of MPTP-treated mice and has provided evidence for a possible calpain-mediated SC neuronal death in MPTP-induced parkinsonism in mice. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARKINSON'S disease
KW - MOVEMENT disorders
KW - DOPAMINERGIC neurons
KW - SUBSTANTIA nigra
KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
KW - Calpain
KW - Double immunofluorescent labeling
KW - Neuronal death
KW - Parkinson's disease
KW - Spinal cord
N1 - Accession Number: 12651625; Chera, Bhisham 1 Schaecher, Kurt E. 1,2 Rocchini, Anne 1 Imam, Syed Z. 3 Sribnick, Eric A. 1 Ray, Swapan K. 1 Ali, Syed F. 3 Banik, Naren L. 1; Email Address: baniknl@musc.edu; Affiliation: 1: Department of Neurology, Medical University of South Carolina, 96 Jonathan Lucas Street, PO Box 250606, Charleston, SC 29425, USA 2: Department of Microbiology and Immunology, Walter Reed Memorial Institute, Uniformed Services University of the Health Sciences, Baltimore, MD 20814, USA 3: Neurochemisty Laboratory, Division of Neurotoxicology, National Center for Toxicological Research-FDA, Jefferson, AR 72079, USA; Source Info: May2004, Vol. 1006 Issue 2, p150; Subject Term: PARKINSON'S disease; Subject Term: MOVEMENT disorders; Subject Term: DOPAMINERGIC neurons; Subject Term: SUBSTANTIA nigra; Author-Supplied Keyword: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Author-Supplied Keyword: Calpain; Author-Supplied Keyword: Double immunofluorescent labeling; Author-Supplied Keyword: Neuronal death; Author-Supplied Keyword: Parkinson's disease; Author-Supplied Keyword: Spinal cord; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.brainres.2004.01.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kioi, Mitomu
AU - Kawakami, Koji
AU - Puri, Raj K.
T1 - Mechanism of action of interleukin-13 antagonist (IL-13E13K) in cells expressing various types of IL-4R
JO - Cellular Immunology
JF - Cellular Immunology
Y1 - 2004/05//
VL - 229
IS - 1
M3 - Article
SP - 41
EP - 51
SN - 00088749
AB - As interleukin (IL)-13 and IL-4 play a major role in various diseases including asthma, allergy, and malignancies, it is desirable to generate a molecule that blocks the effects of both cytokines. We previously generated a human IL-13 mutant (IL-13E13K), which is a powerful antagonist of IL-13, blocking the biological activities of IL-13. We now show that IL-13E13K also competitively inhibits signaling and biological activities of IL-4 through type II and partially through type III IL-4 receptor (R) system. IL-13E13K completely blocked the IL-4-induced phosphorylation of STAT6 and IL-4-dependent protein synthesis in cells expressing type II and partially type III IL-4R but not type I IL- 4R. Consistent with the inhibition of biological activities, IL-13E13K inhibited IL-4 binding to type II IL-4R-expressing cells but not to type I IL-4R-expressing cells. The inhibition efficiency of IL-4 binding by IL-13E13K was relatively lower compared to wtIL-13 even though IL-13E13K bound to IL-13Rα1 positive cells with a similar affinity to wtIL-13. These results indicate that Glu13 in IL-13 associates with IL-4Rα, and mutation to lysine decreases its binding ability to IL-4Rα chain. IL-13E13K binds to IL- 13Rα1, which is shared by both IL-13R and IL-4R systems. Consequently, IL-13E13K inhibits IL-4 binding to these cells and prevents heterodimer formation between IL-13Rα1 and IL-4Rα chains. This interference by IL-13E13K blocks the biological activities of not only IL-13 but also partially of IL-4. Thus, IL-13E13K may be a useful agent for the treatment of diseases such as asthma, allergic rhinitis, and cancer, which are dependent on signaling through both IL-4 and IL-13 receptors. [Copyright &y& Elsevier]
AB - Copyright of Cellular Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-13
KW - INTERLEUKIN-4
KW - CYTOKINES
KW - CELL culture
KW - Antagonist
KW - Interleukin-13
KW - Interleukin-4
KW - Receptor
KW - Signal transduction
N1 - Accession Number: 14247597; Kioi, Mitomu 1 Kawakami, Koji 1 Puri, Raj K.; Email Address: puri@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: May2004, Vol. 229 Issue 1, p41; Subject Term: INTERLEUKIN-13; Subject Term: INTERLEUKIN-4; Subject Term: CYTOKINES; Subject Term: CELL culture; Author-Supplied Keyword: Antagonist; Author-Supplied Keyword: Interleukin-13; Author-Supplied Keyword: Interleukin-4; Author-Supplied Keyword: Receptor; Author-Supplied Keyword: Signal transduction; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.cellimm.2004.06.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spellberg, Brad
AU - Powers, John H.
AU - Brass, Eric P.
AU - Miller, Loren G.
AU - Edwards Jr., John E.
T1 - Trends in Antimicrobial Drug Development: Implications for the Future.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/05//5/1/2004
VL - 38
IS - 9
M3 - Article
SP - 1279
EP - 1286
SN - 10584838
AB - The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens, the rapid emergence of new infections, and the potential for use of multidrug-resistant agents in bioweapons. Paradoxically, some pharmaceutical companies have indicated that they are curtailing anti-infective research programs. We evaluated the United States Food and Drug Administration (FDA) databases of approved drugs and the research and development programs of the world's largest pharmaceutical and biotechnology companies to document trends in the development of new antimicrobial agents. FDA approval of new antibacterial agents decreased by 56% over the past 20 years (1998-2002 vs. 1983-1987). Projecting future development, new antibacterial agents constitute 6 of 506 drugs disclosed in the developmental programs of the largest pharmaceutical and biotechnology companies. Despite the critical need for new antimicrobial agents, the development of these agents is declining. Solutions encouraging and facilitating the development of new antimicrobial agents are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Anti-infective agents
KW - Infection
KW - Pathogenic microorganisms
KW - Biotechnology industries
KW - Drug development
N1 - Accession Number: 13058758; Spellberg, Brad 1; Powers, John H. 2; Brass, Eric P. 1,3; Miller, Loren G. 1,3; Edwards Jr., John E. 1,3; Email Address: edwards@humc.edu; Affiliations: 1: Research and Education Institute and Department of Medicine, Harbor-University of California, Los Angeles (UCLA), Medical Center, Torrance.; 2: Office of Drug Evaluation IV, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; 3: David Geffen School of Medicine, UCLA, Los Angeles, California.; Issue Info: 5/1/2004, Vol. 38 Issue 9, p1279; Thesaurus Term: Antibacterial agents; Thesaurus Term: Anti-infective agents; Thesaurus Term: Infection; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Biotechnology industries; Subject Term: Drug development; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leaf, Philip J.
AU - Owens, Pamela L.
AU - Leventhal, John M.
AU - Forsyth, Brian W.C.
AU - Vaden-Kiernan, Michael
AU - Epstein, Leonardo D.
AU - Riley, Anne W.
AU - Horwitz, Sarah M.
T1 - Pediatricians' Training and Identification and Management of Psychosocial Problems.
JO - Clinical Pediatrics
JF - Clinical Pediatrics
Y1 - 2004/05//
VL - 43
IS - 4
M3 - Article
SP - 355
EP - 365
SN - 00099228
AB - This study evaluated the association of pediatrician training on the identification and management of current and ongoing emotional or behavioral problems among children ages 4-8 years in 19 practices in south-central Connecticut. Pediatricians with advanced training in psychosocial issues were more likely to identify children's psychosocial problems and use multiple management strategies compared with pediatricians with no specialized training. Although pediatricians with moderate training in psychosocial issues were more likely to identify psychosocial problems compared with pediatricians with no training, there was no relationship between moderate training and management of psychosocial problems. These results suggest that identification and management of young children's psychosocial problems demands advanced training and support the American Academy of Pediatrics' call for more extensive training. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pediatrics is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BEHAVIOR disorders in children
KW - EMOTIONAL problems of children
KW - CHILD psychology
KW - CHILD mental health
KW - PEDIATRICS
KW - CHILD psychopathology
N1 - Accession Number: 13143762; Leaf, Philip J. 1 Owens, Pamela L. 1,2 Leventhal, John M. 3,4 Forsyth, Brian W.C. 3,4 Vaden-Kiernan, Michael 5 Epstein, Leonardo D. 6,7 Riley, Anne W. 8 Horwitz, Sarah M. 3,9,10; Affiliation: 1: Department of Mental Health, Johns Hopkins Bloomberg School of Public Helath, MD 2: Agency for Healthcare Research and Quality, MD 3: Child Study Center 4: Department of Pediatrics, Yale University School of Medicine, CT 5: The CDM Group, Inc., Chevy Chase, MD 6: Department of International Health, Johns Hopkins Bloomberg School of Public Health, MD 7: Department of Statistics, Catholic University of Chile, Chile 8: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, MD 9: Department of Epidemiology and Public Helath, Yale University School of Medicine, CT 10: Department of Psychiatry, Case Western Reserve School of Medicine, OH; Source Info: May2004, Vol. 43 Issue 4, p355; Subject Term: BEHAVIOR disorders in children; Subject Term: EMOTIONAL problems of children; Subject Term: CHILD psychology; Subject Term: CHILD mental health; Subject Term: PEDIATRICS; Subject Term: CHILD psychopathology; Number of Pages: 11p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rabatsky-Her, Therese
AU - Whichard, Jean
AU - Rossiter, Shannon
AU - Holland, Ben
AU - Stamey, Karen
AU - Headrick, Marcia L.
AU - Barrett, Timothy J.
AU - Angulo, Frederick J.
T1 - Multidrug-resistant Strains of Salmonella enterica Typhimurium, United States, 1997-1998.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/05//
VL - 10
IS - 5
M3 - Article
SP - 795
EP - 801
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - To evaluate multidrug-resistant strains of Salmonella enterica serotype Typhimurium, including definitive type 104 (DT104) in the United States, we reviewed data from the National Antimicrobial Resistance Monitoring System (NARMS). In 1997 to 1998, 703 (25%) of 2,767 serotyped Salmonella isolates received at NARMS were S. Typhimurium; antimicrobial susceptibility testing and phage typing were completed for 697. Fifty-eight percent (402) were resistant to ≥1 antimicrobial agent. Three multidrug-resistant (≥5 drugs) strains accounted for (74%) 296 of all resistant isolates. Ceftriaxone resistance was present in 8 (3%), and nalidixic acid resistance in 4 (1%), of these multidrug-resistant strains. By phage typing, 259 (37%) of S. Typhimurium isolates were DT104, 209 (30%) were of undefined type and 103 (15%) were untypable. Fifty percent (202) of resistant (≥1 drug) isolates were DT104. Multidrug-resistant S. Typhimurium isolates, particularly DT104, account for a substantial proportion of S. Typhimurium isolates; ceftriaxone resistance is exhibited by some of these strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbiology
KW - Drug resistance in microorganisms
KW - Salmonella typhimurium
KW - Effect of drugs on microorganisms
KW - United States
N1 - Accession Number: 13027553; Rabatsky-Her, Therese 1; Email Address: Therese.Rabatsky-Ehr@po.state.ct.us; Whichard, Jean 2; Rossiter, Shannon 2; Holland, Ben 2; Stamey, Karen 2; Headrick, Marcia L. 3; Barrett, Timothy J. 2; Angulo, Frederick J. 2; Affiliations: 1: Yale University School of Medicine, New Haven, Connecticut, USA; 2: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: U.S. Food and Drug Administration, Bethesda, Maryland, USA; Issue Info: May2004, Vol. 10 Issue 5, p795; Thesaurus Term: Microbiology; Subject Term: Drug resistance in microorganisms; Subject Term: Salmonella typhimurium; Subject Term: Effect of drugs on microorganisms; Subject: United States; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Olsen, Sonja J.
AU - Ying, Michelle
AU - Davis, Meghan F.
AU - Deasy, Marshall
AU - Holland, Ben
AU - Iampietro, Larry
AU - Baysinger, C. Michael
AU - Sassano, Frances
AU - Polk, Lewis D.
AU - Gormley, Betty
AU - Hung, Mary Jane
AU - Pilot, Keith
AU - Orsini, Maria
AU - Van Duyne, Susan
AU - Rankin, Shelley
AU - Genese, Carol
AU - Bresnitz, Eddy A.
AU - Smucker, Joseph
AU - Moll, Maria
AU - Sobel, Jeremy
T1 - Multidrug-resistant Salmonella Typhimurium Infection for Milk Contaminated after Pasteurization.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/05//
VL - 10
IS - 5
M3 - Article
SP - 932
EP - 935
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - An outbreak of multidrug-resistant Salmonella enterica serotype Typhimurium infections occurred in Pennsylvania and New Jersey. A case-control study implicated pasteurized milk from a dairy, and an inspection indicated the potential for contamination after pasteurization. Dairy cattle are the likely reservoir, and milk may be an important vehicle of Salmonella transmission to humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Milk contamination
KW - Drug resistance in microorganisms
KW - Salmonella typhimurium
KW - Pennsylvania
KW - New Jersey
KW - United States
N1 - Accession Number: 13027907; Olsen, Sonja J. 1; Email Address: sco2@cdc.gov; Ying, Michelle 1; Davis, Meghan F. 1; Deasy, Marshall 2; Holland, Ben 1; Iampietro, Larry 2; Baysinger, C. Michael 3; Sassano, Frances 4; Polk, Lewis D. 4; Gormley, Betty 5; Hung, Mary Jane 6; Pilot, Keith 6; Orsini, Maria 6; Van Duyne, Susan 1; Rankin, Shelley 7; Genese, Carol 6; Bresnitz, Eddy A. 6; Smucker, Joseph 8; Moll, Maria 2; Sobel, Jeremy 1; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Pennsylvania Department of Health, Harrisburg, Pennsylvania, USA; 3: Montgomery County Department of Health, Norristown, Pennsylvania, USA; 4: Bucks County Department of Health, Doylestown, Pennsylvania, USA; 5: Gloucester County Health Department, Turnersville, New Jersey, USA; 6: New Jersey State Department of Health and Senior Services, Trenton, New Jersey, USA; 7: University of Pennsylvania, Philadelphia, Pennsylvania, USA; 8: U.S. Food and Drug Administration, Washington, D.C., USA; Issue Info: May2004, Vol. 10 Issue 5, p932; Thesaurus Term: Milk contamination; Subject Term: Drug resistance in microorganisms; Subject Term: Salmonella typhimurium; Subject: Pennsylvania; Subject: New Jersey; Subject: United States; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Luostarinen, T.
AU - Lehtinen, M.
AU - Bjørge, T.
AU - Abeler, V.
AU - Hakama, M.
AU - Hallmans, G.
AU - Jellum, E.
AU - Koskela, P.
AU - Lenner, P.
AU - Lie, A.K.
AU - Paavonen, J.
AU - Pukkala, E.
AU - Saikku, P.
AU - Sigstad, E.
AU - Thoresen, S.
AU - Youngman, L.D.
AU - Dillner, J.
AU - Hakulinen, T.
T1 - Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteri
JO - European Journal of Cancer
JF - European Journal of Cancer
Y1 - 2004/05//
VL - 40
IS - 7
M3 - Article
SP - 1058
SN - 09598049
AB - This case–control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG antibodies. The odds ratio (OR) for the second-order interaction of HPV16, HPV6/11 and C. trachomatis was small (1.0) compared to the expected multiplicative OR, 57, and the additive OR, 11. The interactions were not materially different among HPV16 DNA-positive squamous cell carcinomas. When HPV16 was replaced with HPV18/33 in the analysis of second-order interactions with HPV6/11 and C. trachomatis, there was no evidence of interaction, the joint effect being close to the expected additive OR. Possible explanations for the observed antagonism include misclassification, selection bias or a true biological phenomenon with HPV6/11 and C. trachomatis exposures antagonizing the carcinogenic effects of HPV16. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - PAPILLOMAVIRUSES
KW - UTERUS
KW - INFECTION
KW - Cervix
KW - Chlamydia trachomatis
KW - Interaction
KW - Neoplasms
KW - Papillomaviruses
N1 - Accession Number: 12853914; Luostarinen, T. 1; Email Address: tapio.luostarinen@cancer.fi Lehtinen, M. 2 Bjørge, T. 3 Abeler, V. 3 Hakama, M. 4 Hallmans, G. 5 Jellum, E. 6 Koskela, P. 7 Lenner, P. 8 Lie, A.K. 3 Paavonen, J. 9 Pukkala, E. 1 Saikku, P. 10 Sigstad, E. 3 Thoresen, S. 11 Youngman, L.D. 12 Dillner, J. 13 Hakulinen, T. 14; Affiliation: 1: Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Box 169, FIN-00171 Helsinki, Finland 2: Department of Infectious Disease Epidemiology, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland 3: Department of Pathology, The Norwegian Radium Hospital, Montebello, NO-0310 Oslo, Norway 4: Tampere School of Public Health, FIN-33014 University of Tampere, Finland 5: Department of Public Health and Clinical Medicine, Nutritional Research, University of Umeå, SE-90185 Umeå, Sweden 6: Janus Committee, Norwegian Cancer Society, NO-0369 Oslo, Norway 7: Department of Microbiology, National Public Health Institute, Box 310, FIN-90101 Oulu, Finland 8: Department of Oncology, University of Umeå, SE-90187 Umeå, Sweden 9: Department of Obstetrics and Gynecology, University of Helsinki, Box 140, FIN-00029 HUS, Finland 10: Department of Medical Microbiology, Box 5000, FIN-90014 University of Oulu, Finland 11: The Cancer Registry of Norway, Institute for Epidemiological Cancer Research, Montebello, NO-0310 Oslo, Norway 12: Office of Research, US Department of Health and Human Services, 8401 Muirkirk Road, Laurel, MD-20708, USA 13: Department of Medical Microbiology, Lund University, MAS University Hospital, SE-20502 Malmö, Sweden 14: Department of Public Health, Box 41, FIN-00014 University of Helsinki, Finland; Source Info: May2004, Vol. 40 Issue 7, p1058; Subject Term: CANCER; Subject Term: PAPILLOMAVIRUSES; Subject Term: UTERUS; Subject Term: INFECTION; Author-Supplied Keyword: Cervix; Author-Supplied Keyword: Chlamydia trachomatis; Author-Supplied Keyword: Interaction; Author-Supplied Keyword: Neoplasms; Author-Supplied Keyword: Papillomaviruses; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ejca.2003.11.032
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Herrell, James M.
AU - Burgdorf, Kenneth
AU - Porowski, Allan W.
AU - Yu, Ping
T1 - Residential substance abuse treatment for pregnant and parenting women: findings from a multisite demonstration project
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Editorial
SP - 187
SN - 01497189
AB - This Special Issue presents findings from a multisite, multiyear national demonstration project funded by the Center for Substance Abuse Treatment, in the Substance Abuse and Mental Health Services Administration. The project evaluation examined the clinical effectiveness and costs of providing concurrent residential care for infants and/or young children while providing comprehensive, gender-specific, culturally appropriate residential treatment for their mothers. This issue contains findings from the national evaluation and from studies conducted at individual sites. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANT women
KW - HEALTH promotion
KW - ADDICTIONS
KW - Evaluation
KW - Gender-specific
KW - Parenting women
KW - Pregnant women
KW - Residential treatment program
KW - Substance abuse treatment
N1 - Accession Number: 12573532; Herrell, James M. 1; Email Address: jherrell@samhsa.gov; Burgdorf, Kenneth 2; Porowski, Allan W. 2; Yu, Ping 3; Affiliations: 1: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockwall II, #8-179, Rockville, MD 20857, USA; 2: Caliber Associates, Fairfax, VA, USA; 3: Battelle Centers for Public Health Research and Evaluation, Arlington, VA, USA; Issue Info: May2004, Vol. 27 Issue 2, p187; Subject Term: SUBSTANCE abuse; Subject Term: PREGNANT women; Subject Term: HEALTH promotion; Subject Term: ADDICTIONS; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Gender-specific; Author-Supplied Keyword: Parenting women; Author-Supplied Keyword: Pregnant women; Author-Supplied Keyword: Residential treatment program; Author-Supplied Keyword: Substance abuse treatment; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.evalprogplan.2004.01.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573532&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Porowski, Allan W.
AU - Burgdorf, Kenneth
AU - Herrell, James M.
T1 - Effectiveness and sustainability of residential substance abuse treatment programs for pregnant and parenting women
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Article
SP - 191
SN - 01497189
AB - This paper summarizes outcome findings from an evaluation of residential treatment projects funded by the Center for Substance Abuse Treatment (CSAT), in the Substance Abuse and Mental Health Services Administration, under its Residential Women and Children and Pregnant and Postpartum Women demonstration programs. It first examines client-level treatment outcomes as indicated by pre–post changes in drug and alcohol use, criminal involvement, economic well-being, parenting success, and other important outcome dimensions. Post-treatment status was assessed through interviews administered 6 months after discharge to a sample of approximately 1200 former clients from 32 treatment sites. The paper also examines projects'' success in obtaining continuation funding after the initial 5-year CSAT grant ended. Project sustainability provides another major indicator of the perceived value and effectiveness of the treatment program''s services. Key findings were that a majority of former clients (61%) reported being completely drug- and alcohol-free throughout the follow-up period, large pre–post improvements were noted in other important areas of client and family functioning, and most of the projects begun with CSAT seed-money support (92%) were able to continue operations after the grant support ended. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANT women
KW - HEALTH promotion
KW - ADDICTIONS
KW - Relapse
KW - Residential treatment
KW - Substance abuse
KW - Sustainability
KW - Treatment
N1 - Accession Number: 12573533; Porowski, Allan W. 1; Email Address: porowski@calib.com; Burgdorf, Kenneth 1; Herrell, James M. 2; Affiliations: 1: Caliber Associates, 10530 Rosehaven Street, Suite 400, Fairfax, VA 22030, USA; 2: Center for Substance Abuse Treatment, 5600 Fishers Lane, Rockwall II, #8-179, Rockville, MD 20857, USA; Issue Info: May2004, Vol. 27 Issue 2, p191; Subject Term: SUBSTANCE abuse; Subject Term: PREGNANT women; Subject Term: HEALTH promotion; Subject Term: ADDICTIONS; Author-Supplied Keyword: Relapse; Author-Supplied Keyword: Residential treatment; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Sustainability; Author-Supplied Keyword: Treatment; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2004.01.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573533&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Burgdorf, Kenneth
AU - Dowell, Kathleen
AU - Chen, Xiaowu
AU - Roberts, Tracy
AU - Herrell, James M.
T1 - Birth outcomes for pregnant women in residential substance abuse treatment
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Article
SP - 199
SN - 01497189
AB - This exploratory study investigates impacts of residential substance abuse treatment in reducing risks of adverse pregnancy outcomes. Pregnancy outcomes for 739 women who delivered in treatment were compared to findings from previous research on outcomes for drug-using women, outcomes for clients'' previous pregnancies, and national infant morbidity and mortality rates. Infants born during their mothers'' treatment had substantially lower rates of mortality and morbidity than all comparison groups, including the general US population. The findings suggest that residential substance abuse treatment can substantially reduce risks of negative birth outcomes for pregnant women. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - PREGNANT women
KW - INFANT mortality
KW - CHILDBIRTH
KW - Infant morbidity
KW - Infant mortality
KW - Pregnant women
KW - Retention
KW - Substance abuse treatment
N1 - Accession Number: 12573534; Burgdorf, Kenneth 1; Dowell, Kathleen 1; Chen, Xiaowu 1; Roberts, Tracy 1; Herrell, James M. 2; Email Address: jherrell@samhsa.gov; Affiliations: 1: Caliber Associates, 10530 Rosehaven Street, Suite 400, Fairfax, VA, USA; 2: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockwall II, 8-179, Rockville, MD 20857, USA; Issue Info: May2004, Vol. 27 Issue 2, p199; Subject Term: SUBSTANCE abuse; Subject Term: PREGNANT women; Subject Term: INFANT mortality; Subject Term: CHILDBIRTH; Author-Supplied Keyword: Infant morbidity; Author-Supplied Keyword: Infant mortality; Author-Supplied Keyword: Pregnant women; Author-Supplied Keyword: Retention; Author-Supplied Keyword: Substance abuse treatment; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2004.01.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573534&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Chen, Xiaowu
AU - Burgdorf, Kenneth
AU - Dowell, Kathleen
AU - Roberts, Tracy
AU - Porowski, Allan
AU - Herrell, James M.
T1 - Factors associated with retention of drug abusing women in long-term residential treatment
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Article
SP - 205
SN - 01497189
AB - This study examines factors associated with retention at 50 projects funded by the Center for Substance Abuse Treatment, in the Substance Abuse and Mental Health Services Administration, under its Residential Women and Children and Pregnant and Postpartum Women (RWC/PPW) Demonstration Program. These programs provided long-term, intensive residential treatment for pregnant and parenting women and their children. Data for this study were collected from 3265 clients from 24 six-month and 26 twelve-month RWC/PPW projects, admitted to and discharged from treatment between January 1, 1995 and March 31, 2001. Results from an analysis of covariance (ANCOVA) model indicate that, for both 6- and 12-month projects, significant predictors of retention include: bringing children into treatment, age, and coercion (either through CJS or CPS actions). In six-month projects, longer LOS was also associated with frequency of client–counselor contact, as well as with pregnancy status. Taken together, these findings suggest that enabling parenting women to remain together with their children during residential treatment is an important key to achieving the extended period of stay needed to accomplish treatment objectives. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of covariance
KW - PREGNANCY
KW - HEALTH promotion
KW - CHILDREN
KW - Children
KW - Length of stay
KW - Pregnancy
KW - Retention
N1 - Accession Number: 12573535; Chen, Xiaowu 1; Burgdorf, Kenneth 1; Dowell, Kathleen 1; Roberts, Tracy 1; Porowski, Allan 1; Herrell, James M. 2; Email Address: jherrell@samhsa.gov; Affiliations: 1: Caliber Associates, 10530 Rosehaven Street, Ste. 400, Fairfax, VA 22030, USA; 2: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockwall II, 8-179, Rockville, MD 20857, USA; Issue Info: May2004, Vol. 27 Issue 2, p205; Thesaurus Term: ANALYSIS of covariance; Subject Term: PREGNANCY; Subject Term: HEALTH promotion; Subject Term: CHILDREN; Author-Supplied Keyword: Children; Author-Supplied Keyword: Length of stay; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: Retention; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2004.01.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573535&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Ellis, Bruce
AU - Bernichon, Tiffiny
AU - Yu, Ping
AU - Roberts, Tracy
AU - Herrell, James M.
T1 - Effect of social support on substance abuse relapse in a residential treatment setting for women
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Article
SP - 213
SN - 01497189
AB - This study looked at the influence of family functioning, activities of friends, and substance abuse by spouses or significant others on women''s substance abuse relapse within 6 months following residential treatment. Data were from the Center for Substance Abuse Treatment''s national cross-site evaluation of 6-month residential treatment programs for women with children and pregnant/postpartum women (RWC/PPW). At treatment admission 1758 RWC/PPW clients were interviewed, and 1181 were followed up 6 months after discharge from treatment. Relapse was defined as any use of alcohol or drugs other than nicotine. Positive activities such as families getting along and helping each other during the post-discharge period significantly decreased the likelihood of relapse, while negative activities such as family fights and drug use or criminal activity by friends increased the likelihood of relapse. Post-discharge alcohol and other drug abuse by spouses or significant others also significantly increased the likelihood of relapse. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL networks
KW - SUBSTANCE abuse
KW - SOCIAL support
KW - DISEASE relapse
KW - Family support
KW - Relapse
KW - Residential treatment
KW - Social network
KW - Social support
KW - Substance abuse treatment
N1 - Accession Number: 12573536; Ellis, Bruce 1; Email Address: ellis@battelle.org; Bernichon, Tiffiny 1; Yu, Ping 1; Roberts, Tracy 2; Herrell, James M. 3; Affiliations: 1: Battelle Centers for Public Health Research and Evaluation, 2101 Wilson Boulevard, Suite 800, Arlington, VA 22201, USA; 2: Caliber Associates, 10530 Rosehaven Street, Suite 400, Fairfax, VA 20120, USA; 3: Center for Substance Abuse Treatment, Rockwall II, 5515 Security Lane, Rockville, MD 20852, USA; Issue Info: May2004, Vol. 27 Issue 2, p213; Thesaurus Term: SOCIAL networks; Subject Term: SUBSTANCE abuse; Subject Term: SOCIAL support; Subject Term: DISEASE relapse; Author-Supplied Keyword: Family support; Author-Supplied Keyword: Relapse; Author-Supplied Keyword: Residential treatment; Author-Supplied Keyword: Social network; Author-Supplied Keyword: Social support; Author-Supplied Keyword: Substance abuse treatment; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2004.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573536&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Burgdorf, Kenneth
AU - Layne, Mary
AU - Roberts, Tracy
AU - Miles, Dan
AU - Herrell, James M.
T1 - Economic costs of residential substance abuse treatment for pregnant and parenting women and their children
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2004/05//
VL - 27
IS - 2
M3 - Article
SP - 233
SN - 01497189
AB - This paper provides basic information about the economic cost of substance abuse treatment provided in 39 demonstration projects funded by the Center for Substance Abuse Treatment, in the Substance Abuse and Mental Health Services Administration, under its Residential Women and Children and Pregnant and Postpartum Women (RWC/PPW) programs. It integrates data assembled in two studies, a study of annual project implementation costs based on the CSAT-developed Substance Abuse Treatment Cost Analysis and Allocation Template (SATCAAT) and a cross-site study of other project and client characteristics. Findings indicate that the average economic cost of treating a woman and her infants and young children in this type of long-term residential program, in fiscal 1997 dollars, was $25,744. This cost had three components of roughly equal size: services for clients, services for clients'' children, and housing. Clinical services were found to be highly front-loaded, being more intensive in the initial weeks of treatment than in later stabilization phases. Considerable project-to-project variation in average episode cost was observed, linked primarily to project differences in size/occupancy and in average client length of stay. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COST
KW - SUBSTANCE abuse -- Treatment
KW - PREGNANT women
KW - Economic cost
KW - Parenting women
KW - Pregnant women
KW - Substance abuse treatment
N1 - Accession Number: 12573538; Burgdorf, Kenneth 1; Layne, Mary 1; Roberts, Tracy 1; Miles, Dan 2; Herrell, James M. 3; Email Address: jherrell@samhsa.gov; Affiliations: 1: Caliber Associates, 10530 Rosehaven Street, Suite 400, Fairfax, VA 22030, USA; 2: Capital Consulting Corporation, 7606 Highway 42W, Raleigh, NC 27603, USA; 3: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockwall II, #8-179, Rockville, MD 20857, USA; Issue Info: May2004, Vol. 27 Issue 2, p233; Thesaurus Term: COST; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: PREGNANT women; Author-Supplied Keyword: Economic cost; Author-Supplied Keyword: Parenting women; Author-Supplied Keyword: Pregnant women; Author-Supplied Keyword: Substance abuse treatment; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2004.01.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=12573538&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Pak, Kyungran
AU - Pothuluri, Jairaj V.
AU - Cerniglia, Carl E.
T1 - Mineralization of erythromycin A in aquaculture sediments
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/05//
VL - 234
IS - 1
M3 - Article
SP - 169
SN - 03781097
AB - Mineralization of erythromycin A was studied using two differently 14C-labeled erythromycins A, which were added to aquaculture sediment samples obtained from the two salmon hatchery sites in Washington state. The added erythromycin A did not significantly alter the numbers of the total viable colonies and erythromycin-resistant bacteria. Erythromycin-resistant Pseudomonas species contained a constitutive erythromycin esterase activity contributing to the inactivation of biologically active erythromycin A in aquatic and sediment environments. The initial rate of mineralization of erythromycin A appeared to be governed by the rate of release of soil-sorbed erythromycin A. After a prolonged lag time, the S-curves of erythromycin A mineralization were observed probably because of the increase in the population density metabolizing it. This study suggests that erythromycin A is partially or completely mineralized by the sediment microbial populations. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aquaculture
KW - Soil mineralogy
KW - Erythromycin
KW - Biomineralization
KW - Desorption
KW - Erythromycin A
KW - Erythromycin esterase
KW - Microcosm
KW - Mineralization
N1 - Accession Number: 12898723; Kim, Yong-Hak; Pak, Kyungran 1; Pothuluri, Jairaj V. 1; Cerniglia, Carl E.; Email Address: ccerniglia@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA; Issue Info: May2004, Vol. 234 Issue 1, p169; Thesaurus Term: Aquaculture; Thesaurus Term: Soil mineralogy; Subject Term: Erythromycin; Subject Term: Biomineralization; Author-Supplied Keyword: Desorption; Author-Supplied Keyword: Erythromycin A; Author-Supplied Keyword: Erythromycin esterase; Author-Supplied Keyword: Microcosm; Author-Supplied Keyword: Mineralization; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.femsle.2004.03.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12898723&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Il Kim, Pyoung
AU - Chung, Ki-Chul
T1 - Production of an antifungal protein for control of Colletotrichum lagenarium by Bacillus amyloliquefaciens MET0908
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/05//
VL - 234
IS - 1
M3 - Article
SP - 177
SN - 03781097
AB - A plant pathogenic fungus, Colletotrichum lagenarium, causing watermelon anthracnose, was isolated from naturally infected leaves, stems, and fruits of watermelon. A bacterial strain, MET0908, showing a potent antifungal activity against C. lagenarium, was isolated from soil. An antifungal protein was purified by 30% ammonium sulfate saturation and concentrated using Centricon 10, DEAE–SepharoseTM Fast Flow column and Sephacryl S-100 gel filtration chromatography. The molecular weight of the purified protein was estimated as 40 kDa by SDS–PAGE. The purified protein was stable at 80 °C for 20 min and exhibited a broad spectrum of antifungal activity against various plant pathogenic fungi. Confocal microscopy image analysis and scanning electron microscopy showed that the protein acted on the cell wall of C. lagenarium. The purified antifungal protein exhibited β-1,3-glucanase activity. The N-terminal amino acid sequence of the purified protein was determined as Ser-Lys-Ile-x-Ile-Asn-Ile-Asn-Ile-x-Gln-Ala-Pro-Ala-Pro-x-Ala. A search of the sequence with NCBI BLAST showed no significant homology with any known proteins, suggesting that the purified protein may be novel. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic fungi
KW - Antifungal agents
KW - Colletotrichum lagenarium
KW - Gel permeation chromatography
KW - β-Glucanase
KW - Antifungal agent
KW - Bacillus amyloliquefaciens
KW - Watermelon anthracnose
N1 - Accession Number: 12898724; Il Kim, Pyoung 1; Email Address: pkim@nctr.fda.gov; Chung, Ki-Chul 2; Email Address: chungkc@chonnam.ac.kr; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 2: Department of Genetic Engineering and Biotechnology Research Institute, Chonnam National University, Kwangju, Republic of Korea; Issue Info: May2004, Vol. 234 Issue 1, p177; Thesaurus Term: Pathogenic fungi; Thesaurus Term: Antifungal agents; Subject Term: Colletotrichum lagenarium; Subject Term: Gel permeation chromatography; Author-Supplied Keyword: β-Glucanase; Author-Supplied Keyword: Antifungal agent; Author-Supplied Keyword: Bacillus amyloliquefaciens; Author-Supplied Keyword: Watermelon anthracnose; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.femsle.2004.03.032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12898724&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wood, John M.
AU - Webster, Robert G.
AU - Webby, Richard J.
AU - Robertson, James S.
AU - Katz, Jacqueline
AU - Levandowski, Roland A.
AU - Grohmann, Gary
AU - Cox, Nancy
AU - Hay, Alan J.
AU - Tashiro, Masato
AU - Hampson, Alan
AU - Gust, Ian
AU - Stöhr, Klaus
T1 - Influenza pandemic vaccines: the imminent challenges from a technical and regulatory perspective
JO - International Congress Series
JF - International Congress Series
Y1 - 2004/05//
VL - 1263
M3 - Article
SP - 51
SN - 05315131
AB - In 1997, we were ill prepared to produce vaccines in response to the sudden emergence of highly pathogenic H5N1 influenza. This experience stimulated efforts to improve technical and regulatory procedures for pandemic vaccine virus development and, in February 2003, when highly pathogenic H5N1 influenza re-appeared in man, we were able to produce H5N1 vaccine strains by reverse genetics within the space of 3 months. The technical and regulatory progress which made this possible is reviewed and newly developed WHO biosafety risk assessment for vaccine production is described. Recommendations are made for the significant challenges that lie ahead. [Copyright &y& Elsevier]
AB - Copyright of International Congress Series is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - VIRAL vaccines
KW - GENETICS
KW - PATHOLOGY
KW - Pandemic influenza
KW - Reverse genetics
KW - Vaccines
N1 - Accession Number: 13589919; Wood, John M. 1; Email Address: jwood@nibsc.ac.uk Webster, Robert G. 2 Webby, Richard J. 2 Robertson, James S. 1 Katz, Jacqueline 3 Levandowski, Roland A. 4 Grohmann, Gary 5 Cox, Nancy 3 Hay, Alan J. 6 Tashiro, Masato 7 Hampson, Alan 8 Gust, Ian 8 Stöhr, Klaus 9; Affiliation: 1: Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG, UK 2: Department of Infectious Diseases, Division of Virology, St. Jude Children's Research Hospital, Memphis, TN, USA 3: WHO Collaborating Center for Influenza, Centers for Disease Control, Atlanta, GA, USA 4: Office of Vaccines Research and Review, Division of Viral Products, Laboratory of Pediatric and Respiratory Viral Diseases, Center for Biologics Evaluation and Research, Bethesda, MD, USA 5: Therapeutics Goods Administration Laboratories, Woden ACT, Australia 6: WHO Collaborating Centre for Influenza, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK 7: WHO Collaborating Centre for Influenza, National Institute for Infectious Diseases, Tokyo, Japan 8: WHO Collaborating Centre for Influenza, Parkville, Victoria, Australia 9: WHO Global Influenza Programme, WHO, Geneva, Switzerland; Source Info: May2004, Vol. 1263, p51; Subject Term: INFLUENZA; Subject Term: VIRAL vaccines; Subject Term: GENETICS; Subject Term: PATHOLOGY; Author-Supplied Keyword: Pandemic influenza; Author-Supplied Keyword: Reverse genetics; Author-Supplied Keyword: Vaccines; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ics.2004.01.049
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13589919&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Watkins, John
T1 - Effectiveness of incentive payments to family physicians in improving uptake of influenza vaccine in extreme high-risk patients under the age of 65 years
JO - International Congress Series
JF - International Congress Series
Y1 - 2004/05//
VL - 1263
M3 - Article
SP - 573
SN - 05315131
AB - Background: In 2000, the United Kingdom government recommended universal vaccination for all those 65 years and older and those younger with chronic conditions. The UK''s separate administrative health regions adopted this policy, but introduced different funding strategies to improve uptake. England, while offering family doctors a payment for each high-risk individual aged 65 and over, offered no additional payments for targeting the young. In contrast, Wales offered its doctors additional payments regardless of age. This study set out to examine whether these incentive payments resulted in an increased uptake amongst extreme high-risk patients under the age of 65 years. Method: Medical outpatient departments in 13 large hospital sites in Wales were used as a sampling frame and matched for size, socio-economic and demographic characteristics of the populations they serve with hospitals in England. Nurses in charge of the outpatient department were asked to fill out a questionnaire for the first 10 patients who arrived at the general medicine outpatient department during the first week of March 2002. In total, 190 attendees in England and 222 in Wales were recruited. Results: The patients recruited in the two regions were similar in terms of age, sex and chronic disease condition status. No significant difference was found in the uptake rates between patients attending in England and Wales. Overall uptake in both regions was in excess of 80% of patients with chronic health problems and no attendees outside of the recommended groups were vaccinated. No significant difference existed between the uptake rates for the individual chronic disease morbidities either within or between regions. Conclusions: This study found that overall a change in national policy resulted in a dramatic increase in vaccine uptake both overall and within the extreme high-risk groups. Introducing incentives into the influenza vaccine national programme resulted in a general significant increase in uptake in those recommended for vaccination, whereas specific payments for targeting younger individuals resulted in no additional benefit. [Copyright &y& Elsevier]
AB - Copyright of International Congress Series is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA -- Vaccination
KW - INFLUENZA viruses
KW - INFLUENZA -- Prevention
KW - GREAT Britain
KW - High-risk groups
KW - Influenza vaccination rates
KW - United Kingdom national policy
N1 - Accession Number: 13590062; Watkins, John 1; Email Address: john.watkins@nphs.wales.nhs.uk; Affiliation: 1: Department of Epidemiology, University of Wales College of Medicine, National Public Health Service, Mamhilad House, Mamhilad, Pontypool NP4 0YP, Wales, UK; Source Info: May2004, Vol. 1263, p573; Subject Term: INFLUENZA -- Vaccination; Subject Term: INFLUENZA viruses; Subject Term: INFLUENZA -- Prevention; Subject Term: GREAT Britain; Author-Supplied Keyword: High-risk groups; Author-Supplied Keyword: Influenza vaccination rates; Author-Supplied Keyword: United Kingdom national policy; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ics.2004.02.127
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13590062&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mayor, S.
AU - Watkins, J.
AU - Matthews, I.P.
T1 - The effectiveness of influenza vaccination in preventing hospitalisations for acute respiratory disease during the influenza outbreak of 1999–2000—a case-control study
JO - International Congress Series
JF - International Congress Series
Y1 - 2004/05//
VL - 1263
M3 - Article
SP - 577
SN - 05315131
AB - Background: During the influenza outbreak of 1999/2000, in the United Kingdom between weeks 49/99 and 06/00. We set out to prospectively recruit all adult patients with respiratory symptoms admitted to the largest non-teaching hospital in the country. Methods: All patients 18 years and older admitted with acute respiratory symptoms to a large district general hospital, serving a population of 190,000, during a period of influenza activity, were seen and if they fulfilled the case definition criteria for the study were recruited. Details were recorded of their age, chronic disease status, smoking behaviour, alcohol consumption, influenza and pneumococcal vaccination status. Each was matched with community controls for family physician, age, sex, socio-economic and chronic disease status. In addition, the study generated a 2:1 pool of unmatched controls to cases. Using case-control methodology, we set out to estimate the clinical effectiveness of influenza vaccination in preventing hospitalisation and the risks associated with chronic disease, alcohol consumption, smoking behaviour and previous hospitalisation. Presented here are the results for the matched subjects. Results: 346 cases were recruited, 89% with pre-existing chronic disease, matched community controls were found for 326 (95%). In total, the study generated 725 unmatched controls. Matched pair analysis revealed that vaccination protects against hospitalisation with an Odds Ratio of 0.38 (95% CI 0.25 to 0.51) indicating a strong protective effect, giving vaccine effectiveness of 62±13% in preventing hospitalisations. Overwhelmingly previous hospitalisation for respiratory disease (OR 7.6) contributed the greatest risk of being hospitalised with influenza, yet only 33% of cases in recommended groups received vaccination. Conclusions: This study has advantages over some other studies and again shows the benefits of vaccination and reinforces the contribution chronic ill health contributes to the complications of influenza infection and the missed opportunities for protection. [Copyright &y& Elsevier]
AB - Copyright of International Congress Series is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA -- Vaccination
KW - INFLUENZA -- Prevention
KW - RESPIRATORY infections
KW - GREAT Britain
KW - Case-control study
KW - Impact and burden of influenza
KW - Vaccine effectiveness
N1 - Accession Number: 13590063; Mayor, S. 1 Watkins, J.; Email Address: john.watkins@nphs.wales.nhs.uk Matthews, I.P. 1; Affiliation: 1: Department of Epidemiology, University of Wales College of Medicine, National Public Health Service, Mamhilad House, Mamhilad, Pontypool NP4 0YP Wales, UK; Source Info: May2004, Vol. 1263, p577; Subject Term: INFLUENZA -- Vaccination; Subject Term: INFLUENZA -- Prevention; Subject Term: RESPIRATORY infections; Subject Term: GREAT Britain; Author-Supplied Keyword: Case-control study; Author-Supplied Keyword: Impact and burden of influenza; Author-Supplied Keyword: Vaccine effectiveness; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ics.2004.02.143
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13590063&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gallagher, Grant
AU - Eskdale, Joyce
AU - Jordan, William
AU - Peat, Jon
AU - Campbell, John
AU - Boniotto, Michele
AU - Lennon, Greig P.
AU - Dickensheets, Harold
AU - Donnelly, Raymond P.
T1 - Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses
JO - International Immunopharmacology
JF - International Immunopharmacology
Y1 - 2004/05//
VL - 4
IS - 5
M3 - Article
SP - 615
SN - 15675769
AB - Interleukin-19 (IL-19) is a newly discovered member of the IL-10 family of ligands whose function is presently undefined. We recently described its cloning and initial characterization and in so doing, noted that the induction of IL-19 by LPS in human monocytes was down-regulated by interferon-gamma (IFN-γ) and up-regulated by IL-4. This preliminary observation led us to speculate that IL-19 may play a role in the Th1/Th2 system and we examined this hypothesis further. Our results suggested that IL-19 is able to influence the maturation of human T-cells. CD4+ T-cells resulting from SEB stimulation in the presence of IL-19 contained a higher proportion of IL-4 producing cells than those developing in the absence of IL-19. This observation was complimented by the observation that fewer IFN-γ cells accrued in the presence of IL-19, thereby suggesting that IL-19 altered the balance of Th1/Th2 cells in favour of Th2. Furthermore, in whole PBMC cultures, IL-19 up-regulated IL-4 and down-regulated IFNγ in a dose-dependent manner. These results are presented here in review format, in the context of an overall discussion of IL-19 and its receptor. [Copyright &y& Elsevier]
AB - Copyright of International Immunopharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKINS
KW - INTERLEUKIN-10
KW - INTERLEUKIN-4
KW - LIGANDS
KW - MONOCYTES
KW - INTERFERONS
KW - T cells
KW - Induction
KW - Interleukin-19
KW - Th2 response
N1 - Accession Number: 12962108; Gallagher, Grant 1; Email Address: gallaggr@umdnj.edu Eskdale, Joyce 1 Jordan, William 1 Peat, Jon 2 Campbell, John 3 Boniotto, Michele 1 Lennon, Greig P. 1 Dickensheets, Harold 4 Donnelly, Raymond P. 4; Affiliation: 1: Department of Oral Biology, University of Medicine and Dentistry of New Jersey, Room C-636, MSB, 185 South Orange Avenue, Newark, NJ 07103, USA 2: Department of Surgery, University of Glasgow, Glasgow, UK 3: Department of Medicine, University of Glasgow, Glasgow, UK 4: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Source Info: May2004, Vol. 4 Issue 5, p615; Subject Term: INTERLEUKINS; Subject Term: INTERLEUKIN-10; Subject Term: INTERLEUKIN-4; Subject Term: LIGANDS; Subject Term: MONOCYTES; Subject Term: INTERFERONS; Subject Term: T cells; Author-Supplied Keyword: Induction; Author-Supplied Keyword: Interleukin-19; Author-Supplied Keyword: Th2 response; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.intimp.2004.01.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12962108&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuh-Shen Wu
AU - Guor-Cheng Fang
AU - Chia-Chium Chu
AU - Deng-Yuan Ji
AU - Ming-Hsiang Chen
AU - I-Lin Yang
AU - Peter Pi-Cheng Fu
T1 - A study of polycyclic aromatic hydrocarbons in airborne particulate matter in central Taiwan.
JO - International Journal of Environment & Pollution
JF - International Journal of Environment & Pollution
Y1 - 2004/05//
VL - 21
IS - 5
M3 - Article
SP - 471
EP - 480
SN - 09574352
AB - Two sampling sites in central Taiwan, at Hungkuang University (HKU) and Tunghai University (THU), were chosen to contrast the content of polycyclic aromatic hydrocarbons (PAHs) in the atmosphere from November 2000 to April 2001. PAHs that arise from incomplete combustion of organic materials, especially fossil fuels, are the major toxic pollutants in central Taiwan. This study aimed to analyse PAHs, by using a PS-1 sampler and a gas chromatograph/mass selective detector (GC/MSD), and to identify the major sources of PAHs. At the HKU sampling site, the primary emission sources are probably vehicles and coal burning, and vehicular emissions are the primary contributor at the THU sampling site. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Environment & Pollution is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Hydrocarbons
KW - Air pollution
KW - Fossil fuels
KW - Taiwan
KW - coal combustion
KW - PAH
KW - TSP
KW - vehicular emissions
N1 - Accession Number: 13829847; Yuh-Shen Wu 1; Guor-Cheng Fang 1; Email Address: gcfang@sunrise.hk.edu.tw; Chia-Chium Chu 2; Deng-Yuan Ji 1; Ming-Hsiang Chen 3; I-Lin Yang 3; Peter Pi-Cheng Fu 4; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan; 2: Department of Internal Medicine, Intensive Care Unit, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan; 3: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan; 4: Division of Biochemical Toxicology National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; Issue Info: 2004, Vol. 21 Issue 5, p471; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Hydrocarbons; Thesaurus Term: Air pollution; Thesaurus Term: Fossil fuels; Subject: Taiwan; Author-Supplied Keyword: coal combustion; Author-Supplied Keyword: PAH; Author-Supplied Keyword: TSP; Author-Supplied Keyword: vehicular emissions; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 10p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Iyer, S. Purushothaman
AU - Hislop, David
AU - Jones, Paul L.
AU - Lee, Jaime
AU - Pearce, Frederick
AU - Van Albert, Stephen
T1 - Introductory paper.
JO - International Journal on Software Tools for Technology Transfer
JF - International Journal on Software Tools for Technology Transfer
Y1 - 2004/05//
VL - 5
IS - 4
M3 - Article
SP - 299
EP - 300
SN - 14332779
AB - The computer-assisted resuscitation algorithm (CARA) is the software component of an automatic infusion pump system being designed by US Army’s Walter Reed Institute of Research (WRAIR) to be used in the battlefields of tomorrow. Such medical devices are safety critical, and their use needs to be approved by the US Food and Drug Administration (FDA) – a process on which formal methods can have a great impact. In this special section, six papers on the analysis of CARA’s requirements are presented. In the rest of this introduction, we present the framework and summary of results from those papers. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal on Software Tools for Technology Transfer is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER software
KW - ALGORITHMS
KW - INFUSION therapy -- Equipment & supplies
KW - MEDICAL equipment
KW - UNITED States
KW - Analysis of requirements and designs
KW - Formal methods
KW - Safety of software
KW - Software in medical devices
KW - US Food and Drug Administration
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 13677718; Iyer, S. Purushothaman 1; Email Address: iyer@sc.ncsu.edu Hislop, David 2; Email Address: hislop@aro.arl.army.mil Jones, Paul L. 3; Email Address: pxj@cdrh.fda.gov Lee, Jaime 4; Email Address: Jaime.Lee@na.amedd.army.mil Pearce, Frederick 4; Email Address: Fredrick.Pearce@na.amedd.army.mil Van Albert, Stephen 4; Email Address: Steve.VanAlbert@na.amedd.army.mil; Affiliation: 1: Department of Computer Science, North Carolina State University, USA 2: Army Research Office, Research Triangle Park, USA 3: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, USA 4: Department of Resuscitative Medicine, Walter Reed Army Institute of Research, Silver Spring, USA; Source Info: May2004, Vol. 5 Issue 4, p299; Subject Term: COMPUTER software; Subject Term: ALGORITHMS; Subject Term: INFUSION therapy -- Equipment & supplies; Subject Term: MEDICAL equipment; Subject Term: UNITED States; Author-Supplied Keyword: Analysis of requirements and designs; Author-Supplied Keyword: Formal methods; Author-Supplied Keyword: Safety of software; Author-Supplied Keyword: Software in medical devices; Author-Supplied Keyword: US Food and Drug Administration; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lard-Whiteford, Sheryl L.
AU - Matecka, Dorota
AU - O'Rear, Julian J.
AU - Yuen, Ita S.
AU - Litterst, Charles
AU - Reichelderfer, Patricia
T1 - Recommendations for the Nonclinical Development of Topical Microbicides for Prevention of HIV Transmission: An Update.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2004/05//5/1/2004
VL - 36
IS - 1
M3 - Article
SP - 541
EP - 552
SN - 15254135
AB - Discusses updates and developments concerning the nonclinical recommendations of a previously published document on the development of microbicides prepared by the International Working Group on Microbicides. General concepts; Regulatory considerations; Product development; Mechanism of action; Activity against vaginal microflora and pathogens; Nonclinical data on toxicology and pharmacokinetics.
KW - ANTI-infective agents
KW - ANTIBACTERIAL agents
KW - ANTIFUNGAL agents
KW - DRUGS
KW - PHARMACEUTICAL industry
KW - PHARMACOKINETICS
KW - antimicrobial activities
KW - HIV
KW - topical microcides
N1 - Accession Number: 13220496; Lard-Whiteford, Sheryl L. 1 Matecka, Dorota 2 O'Rear, Julian J. 2 Yuen, Ita S. 2; Email Address: yueni@cder.fda.gov Litterst, Charles 3 Reichelderfer, Patricia 4; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockvill, MD 2: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockvill, MD 3: National Institute of Allergy and Infectious Disases, National Institutes of Health, Bethesda, MD 4: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Source Info: 5/1/2004, Vol. 36 Issue 1, p541; Subject Term: ANTI-infective agents; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTIFUNGAL agents; Subject Term: DRUGS; Subject Term: PHARMACEUTICAL industry; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: antimicrobial activities; Author-Supplied Keyword: HIV; Author-Supplied Keyword: topical microcides; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 13p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sanderson, W. T.
AU - Stoddard, R. R.
AU - Echt, A. S.
AU - Piacitelli, C. A.
AU - Kim, D.
AU - Horan, J.
AU - Davies, M. M.
AU - McCleery, R. E.
AU - Muller, P.
AU - Schnorr, T. M.
AU - Ward, E. M.
AU - Hales, T. R.
T1 - Bacillus anthracis contamination and inhalational anthrax in a mail processing and distribution center.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2004/05//
VL - 96
IS - 5
M3 - Article
SP - 1048
EP - 1056
PB - Wiley-Blackwell
SN - 13645072
AB - w.t. sanderson, r.r. stoddard, a.s. echt, c.a. piacitelli, d. kim, j. horan, m.m. davies, r.e. mccleery, p. muller, t.m. schnorr, e.m. ward and t.r. hales. 2004. Four inhalational anthrax cases occurred in a large mail processing and distribution center in Washington, DC, after envelopes containing Bacillus anthracis spores were processed. This report describes the results of sampling for B. anthracis spores during investigations conducted in October and December 2001. Wet swabs, wet wipes, vacuum sock, and air-filter samples were collected throughout the facility to characterize the extent of building contamination. The results showed widespread contamination of B. anthracis spores, particularly associated with one delivery bar code sorter (DBCS) machine that had sorted the spore-containing envelopes and an area where the envelopes were handled by postal workers. Spore concentrations decreased as distance from the DBCS machine increased, but spores were widely dispersed into surrounding areas. The spatial distribution of culture positive samples was closely related to the work areas of the inhalational anthrax cases and supported epidemiological evidence that the workers became ill from exposure to B. anthracis spores in areas where the contaminated envelopes had travelled. The results of this investigation were used to guide decontamination efforts and provided baseline spore concentrations for follow-up measurements after the building had been cleaned. Implementing methods to reduce aerosolization and dispersion of dust within the facility would reduce postal workers’ potential exposures to bioterrorism agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Bacillus anthracis
KW - Aerosols (Sprays)
KW - Microbial contamination
KW - Viral contamination
KW - Dispersing agents
KW - Anthrax
KW - Bacillus (Bacteria)
KW - anthrax
KW - bacillus anthracis
KW - bacterial spores
KW - bioterrorism
KW - postal facility
KW - surface sampling
N1 - Accession Number: 12767060; Sanderson, W. T. 1; Email Address: wayne-sanderson@uiowa.edu; Stoddard, R. R. 2; Echt, A. S. 3; Piacitelli, C. A. 3; Kim, D. 4; Horan, J. 5; Davies, M. M. 5; McCleery, R. E. 3; Muller, P. 6; Schnorr, T. M. 3; Ward, E. M. 3; Hales, T. R. 3; Affiliations: 1: The University of Iowa, Iowa City, IA; 2: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA; 3: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH; 4: Epidemiologic Intelligence Service, National Center for Environmental Health; 5: National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA; 6: Muller Architects, Cincinnati, OH, USA; Issue Info: May2004, Vol. 96 Issue 5, p1048; Thesaurus Term: Bacterial diseases; Thesaurus Term: Bacillus anthracis; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Microbial contamination; Thesaurus Term: Viral contamination; Thesaurus Term: Dispersing agents; Subject Term: Anthrax; Subject Term: Bacillus (Bacteria); Author-Supplied Keyword: anthrax; Author-Supplied Keyword: bacillus anthracis; Author-Supplied Keyword: bacterial spores; Author-Supplied Keyword: bioterrorism; Author-Supplied Keyword: postal facility; Author-Supplied Keyword: surface sampling; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1365-2672.2004.02223.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ivan A. Ross
AU - Philip P. Sapienza
AU - Darcy E. Hanes
AU - Widmark Johnson
AU - Chung S. Kim
T1 - Determination of the rat tissue partitioning of endotoxin in vitro for physiologically‐based pharmacokinetic (PBPK) modelingPresented in part at the 2001 Annual Meeting of the Society of Toxicology, San Francisco, CA.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2004/05//
VL - 24
IS - 3
M3 - Article
SP - 177
EP - 181
SN - 0260437X
AB - The biosynthetically double‐labeled lipopolysaccharide (LPS), containing 3H‐labeled on the fatty acyl‐chains and 14C‐labeled on the glucosamine of Salmonella enterica serotype typhimurium, was isolated from bacteria grown in proteose peptone‐beef extract (PPBE) medium in the presence of labeled precursors; 133 µCi/ml of [2‐3H] acetate sodium salt and 0.167 µCi/ml of N‐acetyl[D‐1‐14C]glucosamine. The LPS was extracted from the bacteria with 90% phenol/chloroform/petroleum ether, purified and stored in 0.1% (v/v) triethylamine/10 mM Tris HCl at −70 °C. Tissue slices and portions of the meninges were prepared and incubated in artificial cerebrospinal fluid (CSF) or Krebs phosphate buffer (Krebs) containing 150 ng/ml LPS with [3H] LPS (0.004 µCi/ml, sp. act. 28 µCi/mg LPS). The tissues were incubated under 95% oxygen/5% carbon dioxide at 37 °C with constant agitation until steady‐state uptake was reached (60 min). At the end of the incubation period, tissues were processed for radioactivity measurement. The rat tissue partitioning of LPS in artificial CSF for brain and Krebs for other organs was measured by using the ratio of tissue to medium at the steady state in vitro. The following results were obtained from the study: Heart, 0.15; liver, 0.19; spleen, 0.12; kidney, 0.18; stomach, 0.17; small intestine, 0.18; brain stem, 0.10; cerebellum, 0.11; meninges, 0.77; hippocampus, 0.12; hypothalamus, 0.12; frontal cortex, 0.09 and caudate nucleus, 0.10. This information, along with plasma or blood/buffer partition coefficients, is a requisite for constructing a physiologically‐based pharmacokinetic (PBPK) model of endotoxins for quantitative risk assessment. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endotoxins
KW - Toxicology
KW - Pharmacokinetics
KW - Rats
N1 - Accession Number: 19673069; Ivan A. Ross 1; Philip P. Sapienza 1; Darcy E. Hanes 1; Widmark Johnson 1; Chung S. Kim 1; Affiliations: 1: Of?ce of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204.; Issue Info: May2004, Vol. 24 Issue 3, p177; Thesaurus Term: Endotoxins; Thesaurus Term: Toxicology; Subject Term: Pharmacokinetics; Subject Term: Rats; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lachenbruch, P. A.
AU - Rida, W.
AU - Kou, J.
T1 - Lot Consistency as an Equivalence Problem#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2004/05//
VL - 14
IS - 2
M3 - Article
SP - 275
EP - 290
PB - Taylor & Francis Ltd
SN - 10543406
AB - One requirement for licensure of a vaccine in the United States is demonstration by the manufacturer of consistently produced lots of vaccine. Demonstration of consistency of manufacturing can be viewed as a multigroup equivalence problem. The standard statistical procedures for evaluating equivalence assume normally distributed data and define equivalence margins with respect to group means. As an alternative approach, we define a measure of the similarity among group distributions and their nonparametric estimators. Through computer simulations we explore the statistical properties of an equivalence test based on this estimator and compare them to the standard methods. Preliminary work suggests that a test of similarity can be useful in demonstrating equivalence when distributions are not normal or when there are differences in scale or shape. It appears to detect departures from equivalence that are not reflected by differences among group means. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - ESTIMATION theory
KW - MANUFACTURING processes
KW - DISTRIBUTION (Probability theory)
KW - STATISTICS
KW - COMPUTER simulation
KW - Density estimation
KW - Multiple group equivalence
KW - Overlap.
N1 - Accession Number: 14262593; Lachenbruch, P. A. 1; Email Address: lchenbruch@cber.fda.gov Rida, W. 2 Kou, J. 1; Affiliation: 1: U.S. FDA/Center for Biologics Evaluation and Research, Rockville, Maryland, USA. 2: Statistics Collaborative, Washington, DC, USA.; Source Info: May2004, Vol. 14 Issue 2, p275; Subject Term: VACCINES; Subject Term: ESTIMATION theory; Subject Term: MANUFACTURING processes; Subject Term: DISTRIBUTION (Probability theory); Subject Term: STATISTICS; Subject Term: COMPUTER simulation; Author-Supplied Keyword: Density estimation; Author-Supplied Keyword: Multiple group equivalence; Author-Supplied Keyword: Overlap.; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 16p; Document Type: Article
L3 - 10.1081/BIP-120037179
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hung, H. M. James
AU - Sue-Jane Wang
T1 - Multiple Testing of Noninferiority Hypotheses in Active Controlled Trials#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2004/05//
VL - 14
IS - 2
M3 - Article
SP - 327
EP - 335
PB - Taylor & Francis Ltd
SN - 10543406
AB - For noninferiority testing with the maximum allowable noninferiority margin being prespecified, one can perform valid statistical testing at the same alpha level for multiple noninferiority hypotheses with margins being smaller than this maximum margin. This is easily comprehensible because only one confidence level is used to assess which margins within the interval bounded by the maximum margin can be ruled out. If different confidence intervals are used, e.g., the interval generated from the intent-to-treat population is used for testing superiority and the interval generated from the per-protocol population is used for testing noninferiority, the problem of multiplicity will surface and the adjustment of alpha for each testing may be needed. All these predicate on the condition that at least a certain element of the maximum allowable noninferiority margin, whether it is the entire margin or the fraction of the active control effect to be retained, must be fixed in advance. None of these elements can be allowed to be influenced directly or indirectly by any analysis of the noninferiority trial data. Otherwise, the noninferiority analysis may be invalid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - STATISTICS
KW - CLINICAL medicine -- Research
KW - BIOPHARMACEUTICS
KW - THERAPEUTICS
KW - MEDICINE
KW - Active controlled clinical trial.
KW - Maximum allowable noninferiority margin
KW - Multiple testing
N1 - Accession Number: 14262589; Hung, H. M. James 1; Email Address: hung@cder.fda.gov Sue-Jane Wang 2; Affiliation: 1: Division of Biometrics I, Food and Drug Administration, Rockville, Maryland, USA. 2: Division of Biometrics IL Food and Drug Administration, Rockville, Maryland, USA.; Source Info: May2004, Vol. 14 Issue 2, p327; Subject Term: CLINICAL trials; Subject Term: STATISTICS; Subject Term: CLINICAL medicine -- Research; Subject Term: BIOPHARMACEUTICS; Subject Term: THERAPEUTICS; Subject Term: MEDICINE; Author-Supplied Keyword: Active controlled clinical trial.; Author-Supplied Keyword: Maximum allowable noninferiority margin; Author-Supplied Keyword: Multiple testing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Document Type: Article
L3 - 10.1081/BIP-120037183
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Tsong
AU - Juan Zhang
AU - Sue Jane Wang
T1 - Group Sequential Design and Analysis of Clinical Equivalence Assessment for Generic Nonsystematic Drug Products#.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2004/05//
VL - 14
IS - 2
M3 - Article
SP - 359
EP - 373
PB - Taylor & Francis Ltd
SN - 10543406
AB - Clinical trials with therapeutical endpoints are designed with three arms to demonstrate both the efficacy and the equivalence of the test generic treatment and the reference treatment. A generic drug product is determined to be equivalent to the reference drug product if the ratio or difference between the mean responses is bounded within the pre-specified equivalence limits. Often the trials are oversized for the placebo arm. For improvement, we propose a group sequential design with hierarchical testing for the purpose of terminating the placebo arm before testing equivalence between the test and the reference treatments. The hierarchical feature of the proposal will reduce the sample size of the placebo arm and provide treatments to patients in a more efficient manner in a clinical trial setting. After dropping the placebo arm, the option of allocating the planned but unused sample size from the placebo group to the test and reference groups will increase the sample size and power of the equivalence test without inflating the type I error rate by delaying spending it. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENERIC drugs
KW - CLINICAL trials
KW - THERAPEUTICS
KW - PLACEBOS (Medicine)
KW - SAMPLE size (Statistics)
KW - GENERIC products
KW - Adaptive design.
KW - Group sequential
KW - Hierarchical testing
KW - Nonsystemic drug products
N1 - Accession Number: 14262586; Yi Tsong 1,2; Email Address: TSONG@cder.fda.gov Juan Zhang 1,2 Sue Jane Wang 1,2; Affiliation: 1: Office of Biostatistics, Center of Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA. 2: Center of Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA. Office of Pharmacoepidemiology and Statistical Sciences,; Source Info: May2004, Vol. 14 Issue 2, p359; Subject Term: GENERIC drugs; Subject Term: CLINICAL trials; Subject Term: THERAPEUTICS; Subject Term: PLACEBOS (Medicine); Subject Term: SAMPLE size (Statistics); Subject Term: GENERIC products; Author-Supplied Keyword: Adaptive design.; Author-Supplied Keyword: Group sequential; Author-Supplied Keyword: Hierarchical testing; Author-Supplied Keyword: Nonsystemic drug products; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Document Type: Article
L3 - 10.1081/BIP-120037186
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakubzick, C.
AU - Choi, E. S.
AU - Kunkel, S. L.
AU - Evanoff, H.
AU - Martinez, F. J.
AU - Puri, R. K.
AU - Floherly, K. R.
AU - Toews, G. B.
AU - Colby, T. V.
AU - Kazerooni, E. A.
AU - Gross, B. H.
AU - Travis, W. D.
AU - Hogaboam, C. M.
T1 - Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia.
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
Y1 - 2004/05//
VL - 57
IS - 5
M3 - Article
SP - 477
EP - 486
SN - 00219746
AB - Background: Some idiopathic interstitial pneumonias (IIPs) are characterised by fibroproliferation and deposition of extracellular matrix. Because efficacious treatment options are limited, research has been directed towards understanding the cytokine networks that may affect fibroblast activation and, hence, the progression of certain IIPs. Aims: To examine the expression of interleukin 4 (IL-4), IL- 13, and their corresponding receptor subunits in the various forms of IIP and normal patient groups. Methods: Molecular and immunohistochemical analysis of IL-4, interferon γ (IFNγ), IL-13, IL-4 receptor (IL-R), and IL-13 receptor subunits in surgical lung biopsies (SLBs) from 39 patients (21 usual interstitial pneumonia (UIP), six non-specific interstitial pneumonia (NSIP), eight respiratory bronchiolitic interstitial lung disease (RBILD), and five normal controls). Results: Molecular analysis demonstrated that IL-13Rα2, lL-13Rα1, and IL-4Rα were present in a greater proportion of upper and lower lobe biopsies from patients with UIP than patients with NSIP and RBILD. Immunohistochemical analysis of patients with UIP, NSIP, and RBILD revealed interstitial staining for all three receptor subunits, whereas such staining was only seen in mononuclear cells present in normal SIRs. Fibroblastic foci in patients with UIP strongly stained for IL-4Rα and IL-13Rα2. Localised expression of IL-4Rα was also seen in SLBs from patients with NSIP but not in other groups. Conclusion: Some histological subtypes of IIP are associated with increased pulmonary expression of receptor subunits responsive to IL-4 and IL-13. These findings may be of particular importance in understanding the pathogenesis of lip and, more importantly, may provide important novel therapeutic targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pathology is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PNEUMONIA
KW - INTERLEUKIN-4
KW - LYMPHOCYTES
KW - LUNG diseases
KW - EXTRACELLULAR matrix
KW - EXTRACELLULAR space
N1 - Accession Number: 13266240; Jakubzick, C. 1 Choi, E. S. 1 Kunkel, S. L. 1 Evanoff, H. 1 Martinez, F. J. 2 Puri, R. K. 3 Floherly, K. R. 2 Toews, G. B. 2 Colby, T. V. 4 Kazerooni, E. A. 5 Gross, B. H. 5 Travis, W. D. 6 Hogaboam, C. M. 1; Email Address: Hogaboam@med.umich.edu; Affiliation: 1: Department of Pathology, University of Michigan Medical School, Ann Arbor, Ml 48109-0602, USA. 2: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical School. 3: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852-1448, USA. 4: Mayo Clinic, Scottsdale, AZ 85259, USA. 5: Department of Radiology, University of Michigan Medical School. 6: Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.; Source Info: May2004, Vol. 57 Issue 5, p477; Subject Term: PNEUMONIA; Subject Term: INTERLEUKIN-4; Subject Term: LYMPHOCYTES; Subject Term: LUNG diseases; Subject Term: EXTRACELLULAR matrix; Subject Term: EXTRACELLULAR space; Number of Pages: 10p; Illustrations: 3 Color Photographs, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1136/jcp.2003.012799
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Junjian Z.
AU - Kadlubar, Fred F.
T1 - Mitochondrial Mutagenesis and Oxidative Stress in Human Prostate Cancer.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2004/05//
VL - 22
IS - 1
M3 - Article
SP - 1
EP - 12
SN - 10590501
AB - Prostate cancer is the most common cancer diagnosed in men in the United States, but the primary cause and the molecular events leading to prostate carcinogenesis are poorly understood. Using the approach of laser capture microdissection, we revealed extensive somatic mitochondrial DNA (mtDNA) mutations in prostatic neoplastic lesions. Inspection of the lesion associated mutations not only provided new insights into the genetics of prostate cancer, but also revealed new patterns of mtDNA mutation in prostate carcinogenesis. Further analysis on a high frequency of multiple mutational events observed in the same neoplastic lesion revealed an unusually rapid process in mitochondrial mutagenesis, suggesting a new process of mitochondrial hyper-mutagenesis in cancer cells, likely mediated by cellular oxidative stress. Thus, active mitochondrial mutagenesis in prostate cancer suggests a prominent role of increased cellular oxidative stress in neoplastic transformation and the increased susceptibility of neoplastic cells to oxidative damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE cancer
KW - MUTAGENESIS
KW - OXIDATIVE stress
KW - MITOCHONDRIAL DNA
KW - CELLS
KW - UNITED States
KW - Mitochondrial DNA
KW - Mutation
KW - Oxidative stress
KW - Prostate cancer
N1 - Accession Number: 15494795; Chen, Junjian Z. 1; Email Address: jjchen@nctr.fda.gov Kadlubar, Fred F. 1; Affiliation: 1: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA.; Source Info: May2004, Vol. 22 Issue 1, p1; Subject Term: PROSTATE cancer; Subject Term: MUTAGENESIS; Subject Term: OXIDATIVE stress; Subject Term: MITOCHONDRIAL DNA; Subject Term: CELLS; Subject Term: UNITED States; Author-Supplied Keyword: Mitochondrial DNA; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Prostate cancer; Number of Pages: 12p; Document Type: Article
L3 - 10.1081/GNC-120037931
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seo, K.H.
AU - Valentin-Bon, I.E.
AU - Brackett, R.E.
AU - Holt, P.S.
T1 - Rapid, Specific Detection of Salmonella Enteritidis in Pooled Eggs by Real-Time PCR.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/05//
VL - 67
IS - 5
M3 - Article
SP - 864
EP - 869
SN - 0362028X
AB - An assay was developed for the specific detection of Salmonella Enteritidis in eggs with the use of an application of the fluorogenic 5' nuclease assay (TaqMan). In this assay, a segment of the gene sefA specific to Salmonella group D strains such as Salmonella Enteritidis was used. The amplification of the target gene products was monitored in real-time by incorporating a fluorescent dye-labeled gene-specific probe in the PCR reaction. This method correctly detected and distinguished Salmonella Enteritidis from nearly 50 of non-group D Salmonella and other non-Salmonella strains. Detection of the sefA gene was linear for DNA extracted from approximately 10² to 109 CFU/ml in phosphate-buffered saline and 10³ to 108 CFU/ml in raw egg. In two trials, when applied to detection of Salmonella Enteritidis in homogenized egg pools and compared with conventional culture methods, the newly developed PCR method yielded a 100% correlation with results obtained by a conventional culture method. However, the PCR method required only 2 days, compared to the 5 days required by the culture method. The sensitivity of this assay was approximately less than 1 CFU/600 g of egg pool. The real-time PCR assay proved to be a rapid, highly sensitive test for detection and quantification of low concentrations of Salmonella Enteritidis in egg samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Eggs
KW - Salmonella enteritidis
KW - Polymerase chain reaction
N1 - Accession Number: 13373386; Seo, K.H. 1; Email Address: kseo@cfsan.fda.gov; Valentin-Bon, I.E. 1; Brackett, R.E. 1; Holt, P.S. 2; Affiliations: 1: U.S. Food and Drug Administration, CFSA/OPDFB, 5100 Paint Branch Parkway, College Park, Maryland 20740; 2: U.S. Department of Agricultural Research Service, SEPRL, 934 College Station Roas, Athens, Georgia, 30605, USA; Issue Info: May2004, Vol. 67 Issue 5, p864; Thesaurus Term: Eggs; Subject Term: Salmonella enteritidis; Subject Term: Polymerase chain reaction; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 112310 Chicken Egg Production; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hammack, Thomas S.
AU - Valentin-Bon, Iris E.
AU - Jacobson, Andrew P.
AU - Andrews, Wallace H.
T1 - Relative Effectiveness of the Bacteriological Analytical Manual Method for the Recovery of Salmonella from Whole Cantaloupes and Cantaloupe Rinses with Selected Preenrichment Media and Rapid Methods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/05//
VL - 67
IS - 5
M3 - Article
SP - 870
EP - 877
SN - 0362028X
AB - Soak and rinse methods were compared for the recovery of Salmonella from whole cantaloupes. Cantaloupes were surface inoculated with Salmonella cell suspensions and stored for 4 days at 2 to 6°C. Cantaloupes were placed in sterile plastic bags with a nonselective preenrichment broth at a 1:1.5 cantaloupe weight-to-broth volume ratio. The cantaloupe broths were shaken for 5 min at 100 rpm after which 25-ml aliquots (rinse) were removed from the bags. The 25-ml rinses were preenriched in 225-ml portions of the same uninoculated broth type at 35°C for 24 h (rinse method). The remaining cantaloupe broths were incubated at 35°C for 24 h (soak method). The preenrichment broths used were buffered peptone water (BPW), modified BPW, lactose (LAC) broth, and Universal Preenrichment (UP) broth. The Bacteriological Analytical Manual Salmonella culture method was compared with the following rapid methods: the TECRA Unique Salmonella method, the VIDAS ICS/SLM method, and the VIDAS SLM method. The soak method detected significantly more Salmonella-positive cantaloupes (P < 0.05) than did the rinse method: 367 Salmonella-positive cantaloupes of 540 test cantaloupes by the soak method and 24 Salmonella-positive cantaloupes of 540 test cantaloupes by the rinse method. Overall, BPW, LAC, and UP broths were equivalent for the recovery of Salmonella from cantaloupes. Both the VIDAS ICS/SLM and TECRA Unique Salmonella methods detected significantly fewer Salmonella-positive cantaloupes than did the culture method: the VIDAS ICS/SLM method detected 23 of 50 Salmonella-positive cantaloupes (60 tested) and the TECRA Unique Salmonella method detected 16 of 29 Salmonella-positive cantaloupes (60 tested). The VIDAS SLM and culture methods were equivalent: both methods detected 37 of 37 Salmonella-positive cantaloupes (60 tested). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Bacteriology
KW - Muskmelon
KW - Food poisoning
N1 - Accession Number: 13373387; Hammack, Thomas S. 1; Email Address: Thomas.Hammack@fda.hhs.gov; Valentin-Bon, Iris E. 1; Jacobson, Andrew P. 1; Andrews, Wallace H. 1; Affiliations: 1: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: May2004, Vol. 67 Issue 5, p870; Thesaurus Term: Salmonella; Thesaurus Term: Bacteriology; Thesaurus Term: Muskmelon; Thesaurus Term: Food poisoning; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 8p; Illustrations: 4 Diagrams, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lampel, Keith A.
AU - Dyer, Deanne
AU - Kornegay, Leroy
AU - Orlandi, Palmer A.
T1 - Detection of Bacillus Spores Using PCR and FTA Filters.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/05//
VL - 67
IS - 5
M3 - Article
SP - 1036
EP - 1038
SN - 0362028X
AB - Emphasis has been placed on developing and implementing rapid detection systems for microbial pathogens. We have explored the utility of expanding FTA filter technology for the preparation of template DNA for PCR from bacterial spores. Isolated spores from several Bacillus spp., B. subtilis, B. cereus, and B. megaterium, were applied to FTA filters, and specific DNA products were amplified by PCR. Spore preparations were examined microscopically to ensure that the presence of vegetative cells, if any, did not yield misleading results. PCR primers SRM86 and SRM87 targeted a conserved region of bacterial rRNA genes, whereas primers Bsub5F and Bsub3R amplified a product from a conserved sequence of the B. subtilis rRNA gene. With the use of the latter set of primers for nested PCR, the sensitivity of the PCR-based assay was increased. Overall, 53 spores could be detected after the first round of PCR, and the sensitivity was increased to five spores by nested PCR. FTA filters are an excellent platform to remove PCR inhibitors and have universal applications for environmental, clinical, and food samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial spores
KW - Filters & filtration
KW - Pathogenic microorganisms
KW - Bacillus (Bacteria)
KW - Polymerase chain reaction
N1 - Accession Number: 13373414; Lampel, Keith A. 1; Email Address: klampel@cfsan.fda.gov; Dyer, Deanne 1; Kornegay, Leroy 1; Orlandi, Palmer A. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, Maryland 20708, USA; Issue Info: May2004, Vol. 67 Issue 5, p1036; Thesaurus Term: Bacterial spores; Thesaurus Term: Filters & filtration; Thesaurus Term: Pathogenic microorganisms; Subject Term: Bacillus (Bacteria); Subject Term: Polymerase chain reaction; Number of Pages: 3p; Illustrations: 2 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tomazi-Jezic, Vesna J.
AU - Lucas, Anne D.
AU - Sanchez, Beatriz A.
T1 - Binding and Measuring Natural Rubber Latex Proteins on Glove Powder.
JO - Journal of Immunoassay & Immunochemistry
JF - Journal of Immunoassay & Immunochemistry
Y1 - 2004/05//
VL - 25
IS - 2
M3 - Article
SP - 109
EP - 123
PB - Taylor & Francis Ltd
SN - 15321819
AB - Cornstarch used as a donning powder on natural robber latex (NRL) gloves adsorbs NRL proteins. During glove use, powder-carried proteins can be aerosolized and can cause allergic reactions in NRL sensitized individuals. The amount of NRL proteins bound to glove powder and its relative relationship to the total amount of proteins on the glove has not been studied, due to the difficulty in measuring proteins on powder. Using the ELISA inhibition assay for NRL proteins [Standard test method for the immunological measurement of antigenic protein in natural robber and its products. In: The Annual Book of ASTM Standards; ASTM: West Conshohocken, PA, 2000; ASTM D 64-0] we have investigated possible protocol modifications in order to include measurement of proteins bound to glove powder, as well as the water-extractable glove proteins. Possible interference of the starch itself was evaluated by adding clean cornstarch to the assay. No significant interference was observed with powder concentrations below 5 mg/mL. We analyzed 19 extracts of powdered surgical and examination gloves before and after removal of the particulate component. Comparison of NRL glove extracts with, and without, the cornstarch powder fraction indicated significant variations in the ratios of powder-bound protein and corresponding water-extractable protein. The ratios did not appear to correlate with either the total protein on the glove, the glove weight, or the total amount of powder on the glove. However, when virgin glove powders were exposed to NRL proteins, binding was proportional to the protein concentration in the suspension. Temperature in the range from 4°C to 37°C, did not affect binding intensity, while a higher pH resulted in a higher level of protein associated with, or bound to, the starch. The major differences in the propensity for NRL protein binding were observed among different glove powders. The data indicate that the amount of protein that binds to glove powder does not depend only on the initial protein levels in the raw NRL. More likely, other physical or chemical factors introduced during the manufacturing process, as well as the properties of the donning powder itself, may influence protein binding. Moreover, we demonstrated that the ELISA inhibition assay could be successfully modified for quantitation of proteins adsorbed on the glove powder, together with water-extractable proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunoassay & Immunochemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LATEX
KW - RUBBER
KW - SURGICAL gloves
KW - PROTEINS
KW - ORGANIC compounds
KW - BIOMOLECULES
KW - Glove powder
KW - Latex proteins
KW - Natural rubber latex
N1 - Accession Number: 13578945; Tomazi-Jezic, Vesna J. 1 Lucas, Anne D. 1 Sanchez, Beatriz A. 1; Affiliation: 1: USFDA, Center for Devices and Radiological Health, Division of Life Sciences, Rockville, Maryland, USA; Source Info: May2004, Vol. 25 Issue 2, p109; Subject Term: LATEX; Subject Term: RUBBER; Subject Term: SURGICAL gloves; Subject Term: PROTEINS; Subject Term: ORGANIC compounds; Subject Term: BIOMOLECULES; Author-Supplied Keyword: Glove powder; Author-Supplied Keyword: Latex proteins; Author-Supplied Keyword: Natural rubber latex; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; Number of Pages: 15p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1081/IAS-120030521
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ross, Sharon A.
AU - Milner, John
T1 - Functional Foods & Nutraceuticals in Cancer Prevention (Book).
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
Y1 - 2004/05//May/Jun2004
VL - 36
IS - 3
M3 - Book Review
SP - 162
EP - 162
PB - Elsevier Science
SN - 14994046
AB - Reviews the book "Functional Foods & Nutraceuticals in Cancer Prevention," by R. R. Watson.
KW - FUNCTIONAL foods
KW - NONFICTION
KW - WATSON, R. R.
KW - FUNCTIONAL Foods & Nutraceuticals in Cancer Prevention (Book)
N1 - Accession Number: 13883940; Ross, Sharon A. 1 Milner, John 1; Affiliation: 1: Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 6130 Executive Blvd, EPN 3160, Bethesda, MD 20892-7328; Source Info: May/Jun2004, Vol. 36 Issue 3, p162; Subject Term: FUNCTIONAL foods; Subject Term: NONFICTION; Reviews & Products: FUNCTIONAL Foods & Nutraceuticals in Cancer Prevention (Book); People: WATSON, R. R.; Number of Pages: 3/4p; Illustrations: 1 Black and White Photograph; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - CASE
AU - Hall, Ronald M.
AU - Trout, Douglas
AU - Earnest, G. Scott
T1 - An Industrial Hygiene Survey of an Office Building in the Vicinity of the World Trade Center: Assessment of Potential Hazards Following the Collapse of the World Trade Center Buildings.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/05//
VL - 1
IS - 5
M3 - Case Study
SP - D49
EP - D53
PB - Taylor & Francis Ltd
SN - 15459624
AB - Presents a case study of industrial hygiene in an office building in the vicinity of the World Trade Center Building in New York City. Assessment of potential hazards following the collapse of the building; Characterization of the environment on the floors of the Federal Office Building.
KW - Industrial hygiene
KW - Environmental health
KW - Office buildings
KW - Industrial management
KW - New York (N.Y.)
KW - New York (State)
KW - United States
KW - World Trade Center (New York, N.Y. : 1970-2001)
N1 - Accession Number: 13238737; Hall, Ronald M. 1; Trout, Douglas 1; Earnest, G. Scott 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2004, Vol. 1 Issue 5, pD49; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Thesaurus Term: Office buildings; Subject Term: Industrial management; Subject: New York (N.Y.); Subject: New York (State); Subject: United States ; Company/Entity: World Trade Center (New York, N.Y. : 1970-2001); NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 5p; Document Type: Case Study
L3 - 10.1080/15459620490438802
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DeBord, D. Gayle
AU - Savage Jr., Russell E.
AU - Drexler, Hans
AU - Freeman, Caroline
AU - Goopman, John
AU - Jayjock, Michael
AU - McDiarmid, Melissa
AU - Morgan, Michael
AU - Santella, Regina
AU - Schulte, Paul
AU - Talaska, Glenn
AU - Tardiff, Robert
AU - Viau, Claude
T1 - A Summary of the Workshop "Applying Biomarkers to Occupational Health Practice."
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/05//
VL - 1
IS - 5
M3 - Article
SP - D57
EP - D60
PB - Taylor & Francis Ltd
SN - 15459624
AB - Presents a summary of the workshop titled Applying Biomarkers to Occupational Health Practice in the U.S. Analysis of biomarker application from toxicology perspective; Biomarker research for risk assessment; Background on the development and use of biomarkers.
KW - Biochemical markers
KW - Industrial hygiene
KW - Environmental health
KW - Toxicology
KW - Risk assessment
KW - United States
N1 - Accession Number: 13238800; DeBord, D. Gayle 1; Savage Jr., Russell E. 1; Drexler, Hans 2; Freeman, Caroline 3; Goopman, John 4; Jayjock, Michael 5; McDiarmid, Melissa 6; Morgan, Michael 7; Santella, Regina 8; Schulte, Paul 2; Talaska, Glenn 9; Tardiff, Robert 10; Viau, Claude 11; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: University of Erlangen-Nuremburg, Erlangen, Germany; 3: Occupational Safety and Health Administration, Washington, DC; 4: Johns Hopkins University, Baltimore, Md.; 5: Rohm and Haas, Co, Spring House, Pa.; 6: University of Maryland, Baltimore, Md.; 7: University of Washington, Seattle, Wash.; 8: Columbia University, New york, N.Y.; 9: University of Cincinnati, Cincinnati, Ohio; 10: Sapphire Group, Inc., Washington, D.C.; 11: University of Montreal, Montreal, Canada; Issue Info: May2004, Vol. 1 Issue 5, pD57; Thesaurus Term: Biochemical markers; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Thesaurus Term: Toxicology; Thesaurus Term: Risk assessment; Subject: United States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106684247
T1 - Case studies. An industrial hygiene survey of an office building in the vicinity of the World Trade Center: assessment of potential hazards following the collapse of the World Trade Center buildings.
AU - Hall RM
AU - Trout D
AU - Earnest GS
A2 - Mazzuckelli L
Y1 - 2004/05//
N1 - Accession Number: 106684247. Language: English. Entry Date: 20041105. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Disasters -- New York
KW - Hazardous Materials -- Analysis
KW - Occupational Diseases -- Epidemiology
KW - Sick Building Syndrome -- Epidemiology
KW - National Institute for Occupational Safety and Health
KW - New York
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Sick Building Syndrome -- Etiology
KW - Terrorism
KW - United States
SP - D49
EP - 53
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 15238343.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106684249
T1 - A summary of the workshop 'Applying Biomarkers to Occupational Health Practice'.
AU - DeBord DG
AU - Savage RE Jr.
AU - Drexler H
AU - Freeman C
AU - Groopman J
AU - Jayjock M
AU - McDiarmid M
AU - Morgan M
AU - Santella R
AU - Schulte P
AU - Talaska G
AU - Tardiff R
AU - Viau C
Y1 - 2004/05//
N1 - Accession Number: 106684249. Language: English. Entry Date: 20041105. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Biological Markers -- Analysis
KW - Hazardous Materials -- Poisoning
KW - Occupational Exposure -- Prevention and Control
KW - Occupational Health
KW - Education
SP - D57
EP - 60
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 15238345.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106684249&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Casteel, Carri
AU - Peek-Asa, Corinne
AU - Howard, John
AU - Kraus, Jess F.
T1 - Effectiveness of Crime Prevention Through Envrionmental Design in Reducing Criminal Activity in Liquor Stores: A Pilot Study.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2004/05//
VL - 46
IS - 5
M3 - Article
SP - 450
EP - 458
SN - 10762752
AB - Liquor store employees experience disproportionately higher rates of workplace injury death than employees in any other retail setting. However, efforts to introduce workplace violence prevention programs into liquor stores have been minimal. This study examines the effectiveness of a Crime Prevention Through Environmental Design intervention in reducing criminal activity in Santa Monica, California liquor stores. Nine stores enrolling in the study received an individualized intervention safety plan; the remaining 13 served as a comparison group. Mixed-effects Poisson regression was used to examine intervention effectiveness. The largest reductions in criminal activity occurred for robbery and shoplifting outcomes. WE conclude that the Crime Prevention Through Environmental Design program reduced crime and injury in liquor stores and educated small business about the risks associated with retail violence and the countermeasures that can be taken. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRIME prevention
KW - LIQUOR stores
KW - WORK-related injuries
KW - OCCUPATIONAL medicine
KW - CALIFORNIA
KW - UNITED States
N1 - Accession Number: 13232778; Casteel, Carri 1; Email Address: ccasteel@email.unc.edu Peek-Asa, Corinne 2 Howard, John 3 Kraus, Jess F. 4; Affiliation: 1: Injury Prevention Research Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 2: Injury Prevention Research Center, University of Iowa, Iowa City 3: National Institute for Occupational Safety and Health, University of California, Los Angeles 4: Southern California Injury Prevention Research Center, University of California, Los Angeles; Source Info: May2004, Vol. 46 Issue 5, p450; Subject Term: CRIME prevention; Subject Term: LIQUOR stores; Subject Term: WORK-related injuries; Subject Term: OCCUPATIONAL medicine; Subject Term: CALIFORNIA; Subject Term: UNITED States; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1097/01.jom.000126025.14847.b1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kittusamy, N. Kumar
AU - Buchholz, Bryan
T1 - Whole-body vibration and postural stress among operators of construction equipment: A literature review
JO - Journal of Safety Research
JF - Journal of Safety Research
Y1 - 2004/05//
VL - 35
IS - 3
M3 - Article
SP - 255
EP - 261
SN - 00224375
AB - Introduction: Operators of construction equipment perform various duties at work that expose them to a variety of risk factors that may lead to health problems. A few of the health hazards among operators of construction equipment are: (a) whole-body vibration, (b) awkward postural requirements (including static sitting), (c) dust, (d) noise, (e) temperature extremes, and (f) shift work. It has been suggested that operating engineers (OEs) are exposed to two important risk factors for the development of musculoskeletal disorders: whole-body vibration and non-neutral body postures. Method: This review evaluates selected papers that have studied exposure to whole-body vibration and awkward posture among operators of mobile equipment. There have been only few studies that have specifically examined exposure of these risk factors among operators of construction equipment. Thus other studies from related industry and equipment were reviewed as applicable. Conclusion: In order to better understand whole-body vibration and postural stress among OEs, it is recommended that future studies are needed in evaluating these risk factors among OEs. [Copyright &y& Elsevier]
AB - Copyright of Journal of Safety Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Construction equipment
KW - Posture disorders
KW - Machinery
N1 - Accession Number: 14109395; Kittusamy, N. Kumar 1; Email Address: NFK8@CDC.GOV; Buchholz, Bryan 2; Affiliations: 1: Spokane Research Laboratory, National Institute for Occupational Safety and Health, 315 E. Montgomery Ave., Spokane, WA 99207, USA; 2: Construction Occupational Health Project, University of Massachusetts Lowell, One University Ave., Lowell, MA 01854, USA; Issue Info: May2004, Vol. 35 Issue 3, p255; Thesaurus Term: Health risk assessment; Subject Term: Construction equipment; Subject Term: Posture disorders; Subject Term: Machinery; NAICS/Industry Codes: 333120 Construction Machinery Manufacturing; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417210 Construction and forestry machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 333999 All Other Miscellaneous General Purpose Machinery Manufacturing; NAICS/Industry Codes: 417990 All other machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jsr.2004.03.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cardwell, Kitty F.
AU - Henry, Sara H.
T1 - Risk of Exposure to and Mitigation of Effect of Aflatoxin on Human Health: A West African Example.
JO - Journal of Toxicology -- Toxin Reviews
JF - Journal of Toxicology -- Toxin Reviews
Y1 - 2004/05//
VL - 23
IS - 2/3
M3 - Article
SP - 217
EP - 247
PB - Taylor & Francis Ltd
SN - 07313837
AB - The purpose of this chapter is to examine the relative risk of exposure of different human populations to food-borne aflatoxins; the types of health impact that may be incurred by dietary exposure to aflatoxins; and possible strategies likely to mitigate risks to human health. Risk of exposure is examined in a global context comparing risk of toxin exposure by levels of national socioeconomic development. Then risk of exposure is reexamined in the context of agro-ecology, distribution of toxigenicity of Aspergillus flavus, and social factors that influence food management practices. The effects of aflatoxin exposure on human health are explored in three sections: human disease and nutritional status, carcinogenicity, and child growth and development. The section concerning mitigation of the effects of aflatoxin on human health contrasts efficacy of regulation, food basket modification, and production-side agriculture intervention. It is concluded that risk of hepatocellular carcinoma in developing countries, such as West Africa, may be addressed by vaccination for hepatitis B virus(HBV) and other public health options. Young children in West Africa who are chronically exposed to aflatoxin in foods and who consume nutritionally deficient diets have been shown to be stunted and underweight, as measured by World Health Organization(WHO) Z-scores. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Toxin Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFLATOXINS
KW - MYCOTOXINS -- Physiological effect
KW - FOODBORNE diseases
KW - FOOD -- Safety measures
KW - PUBLIC health
KW - Aflatoxin
KW - Agro-ecology
KW - Aspergillus flavus
KW - Child growth development
KW - Hepatitis B virus
KW - Hepatocellular carcinoma
KW - Nutritional status
KW - West Africa
N1 - Accession Number: 14309934; Cardwell, Kitty F. 1; Email Address: kcardwell@csrees.usda.gov Henry, Sara H. 2; Affiliation: 1: U.S. Department of Agriculture, CSREES Washington, District of Columbia, USA 2: U.S. Food and Drug Administration, CFSAN, Washington, District of Columbia, USA; Source Info: May2004, Vol. 23 Issue 2/3, p217; Subject Term: AFLATOXINS; Subject Term: MYCOTOXINS -- Physiological effect; Subject Term: FOODBORNE diseases; Subject Term: FOOD -- Safety measures; Subject Term: PUBLIC health; Author-Supplied Keyword: Aflatoxin; Author-Supplied Keyword: Agro-ecology; Author-Supplied Keyword: Aspergillus flavus; Author-Supplied Keyword: Child growth development; Author-Supplied Keyword: Hepatitis B virus; Author-Supplied Keyword: Hepatocellular carcinoma; Author-Supplied Keyword: Nutritional status; Author-Supplied Keyword: West Africa; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 31p; Illustrations: 4 Charts, 2 Maps; Document Type: Article
L3 - 10.1081/TXR-200027817
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14309934&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holm, Geoffrey H.
AU - Chengsheng Zhang
AU - Gorry, Paul R.
AU - Peden, Keith
AU - Schols, Dominique
AU - De Clercq, Erik
AU - Gabuzda, Dana
T1 - Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/05//
VL - 78
IS - 9
M3 - Article
SP - 4541
EP - 4551
SN - 0022538X
AB - Apoptosis of uninfected bystander CD4+ T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander apoptosis are not well understood. To investigate properties of the viral envelope glycoproteins (Env proteins) that influence the ability of HIV-1 to induce bystander apoptosis, we used molecularly cloned viruses that differ only in specific amino acids in Env. The ability of these strains to induce bystander apoptosis was tested in herpesvirus saimiri-immortalized primary CD4+ T cells (CD4/HVS), which resemble activated primary T cells. Changes in Env that increase affinity for CD4 or CCR5 or increase coreceptor binding site exposure enhanced the capacity of HIV-1 to induce bystander apoptosis following viral infection or exposure to nonreplicating virions. Apoptosis induced by HIV-1 virions was inhibited by CD4, CXCR4, and CCR5 antibodies or by the CXCR4 inhibitor AMD3100, but not the fusion inhibitor T20. HIV-1 virions with mutant Envs that bind CXCR4 but are defective for CD4 binding or membrane fusion induced apoptosis, whereas CXCR4 binding-defective mutants did not. These results demonstrate that HIV-1 virions induce apoptosis through a CXCR4- or CCR5-dependent pathway that does not require Env/CD4 signaling or membrane fusion and suggest that HIV-1 variants with increased envelope/receptor affinity or coreceptor binding site exposure may promote T-cell depletion in vivo by accelerating bystander cell death. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - T cells
KW - HIV (Viruses)
KW - BINDING sites (Biochemistry)
KW - VIRUS diseases
KW - PROTEINS
KW - BIOLOGICAL membranes
KW - CELL membranes
KW - AMINO acids
KW - CELL death
N1 - Accession Number: 13086833; Holm, Geoffrey H. 1,2 Chengsheng Zhang 1,2 Gorry, Paul R. 1,2 Peden, Keith 3 Schols, Dominique 4 De Clercq, Erik 4 Gabuzda, Dana 1,5; Email Address: dana_gabuzda@dfci.harvard.edu; Affiliation: 1: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School 2: Laboratory of Retrovirus Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland 3: Laboratory of Experimental Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium 4: Department of Pathology 5: Department of Neurology, Harvard Medical School; Source Info: May2004, Vol. 78 Issue 9, p4541; Subject Term: APOPTOSIS; Subject Term: T cells; Subject Term: HIV (Viruses); Subject Term: BINDING sites (Biochemistry); Subject Term: VIRUS diseases; Subject Term: PROTEINS; Subject Term: BIOLOGICAL membranes; Subject Term: CELL membranes; Subject Term: AMINO acids; Subject Term: CELL death; Number of Pages: 11p; Illustrations: 1 Chart, 29 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.9.4541-4551.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lori Brown, S.
AU - Todd, Joan Ferlo
AU - Do Luu, Hoan-My
T1 - Breast Implant Adverse Events during Mammography: Reports to the Food and Drug Administration.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2004/05//
VL - 13
IS - 4
M3 - Article
SP - 371
EP - 378
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - Objective: To characterize reports of adverse events occurring during mammography to women with breast implants submitted to the Food and Drug Administration (FDA). Methods: We searched the adverse events database for any report on silicone gel breast im: plants or saline breast implants that included the word "mammography" or "mammogram" in the text. We also searched adverse event reports for mammographic equipment that included the term "breast implant" in the text. Results: We retrieved 714 adverse event reports using this strategy. Sixty-six of these reports detailed an adverse event that occurred during mammography or described breast implant interference with mammography. The majority of these reports, 41 of 66 (62.1%), described breast implant rupture during mammography. Other adverse events reported included mammographic compression crushing implants, pain during mammography attributed to implants, inability to perform mammography because of capsular contracture or fear of implant rupture, and delayed detection of cancer attributed to implants. Conclusions: It is important that women considering breast implants be informed of these potential risks and that clinicians, radiologists, and mammographic technicians keep them in mind when imaging women with implants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMOGRAMS
KW - SILICONES
KW - BREAST implants
KW - MEDICAL care
KW - RADIOLOGISTS
KW - PHYSICIANS
N1 - Accession Number: 13582398; Lori Brown, S. 1 Todd, Joan Ferlo 1 Do Luu, Hoan-My 2; Affiliation: 1: Division of Postmarket Surveillance, Office of Surveillance and Biometrics. 2: Division of Mechanical and Material Sciences, Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland.; Source Info: May2004, Vol. 13 Issue 4, p371; Subject Term: MAMMOGRAMS; Subject Term: SILICONES; Subject Term: BREAST implants; Subject Term: MEDICAL care; Subject Term: RADIOLOGISTS; Subject Term: PHYSICIANS; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106564300
T1 - Breast implant adverse events during mammography: reports to the Food and Drug Administration.
AU - Brown SL
AU - Todd JF
AU - Luu HD
Y1 - 2004/05//
N1 - Accession Number: 106564300. Language: English. Entry Date: 20050121. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Commentary: Middleton MS. Editorial. (J WOMENS HEALTH (15409996)) May2004; 13 (4): 379-380. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101159262.
KW - Breast Diseases -- Etiology
KW - Breast Implants -- Adverse Effects
KW - Breast -- Pathology
KW - Mammography -- Adverse Effects
KW - Prosthesis Failure
KW - Breast Diseases -- Diagnosis
KW - Databases
KW - Descriptive Research
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - Gels
KW - Polyurethanes
KW - Risk Factors
KW - Rupture -- Etiology
KW - Silicones
KW - United States
KW - United States Food and Drug Administration
KW - Women's Health
KW - Human
SP - 371
EP - 378
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
JA - J WOMENS HEALTH (15409996)
VL - 13
IS - 4
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - OBJECTIVE: To characterize reports of adverse events occurring during mammography to women with breast implants submitted to the Food and Drug Administration (FDA). METHODS: We searched the adverse events database for any report on silicone gel breast implants or saline breast implants that included the word 'mammography' or 'mammogram'in the text. We also searched adverse event reports for mammographic equipment that included the term 'breast implant' in the text. RESULTS: We retrieved 714 adverse event reports using this strategy. Sixty-six of these reports detailed an adverse event that occurred during mammography or described breast implant interference with mammography. The majority of these reports, 41 of 66 (62.1%), described breast implant rupture during mammography. Other adverse events reported included mammographic compression crushing implants, pain during mammography attributed to implants, inability to perform mammography because of capsular contracture or fear of implant rupture, and delayed detection of cancer attributed to implants. CONCLUSIONS: It is important that women considering breast implants be informed of these potential risks and that clinicians, radiologists, and mammographic technicians keep them in mind when imaging women with implants.
SN - 1540-9996
AD - Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Centers for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, HFZ 541, Rockville, MD 20850; syb@cdrh.fda.gov
U2 - PMID: 15195650.
DO - 10.1089/154099904323087042
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106564300&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vilà, Maya R.
AU - Kaplan, Gerardo G.
AU - Feigelstock, Dino
AU - Nadal, Margarita
AU - Morote, Joan
AU - Porta, Ruth
AU - Bellmunt, Joaquim
AU - Meseguer, Anna
T1 - CELL BIOLOGY - IMMUNOLOGY - PATHOLOGY Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma.
JO - Kidney International
JF - Kidney International
Y1 - 2004/05//
VL - 65
IS - 5
M3 - Article
SP - 1761
EP - 1773
SN - 00852538
AB - Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma. Background. The molecular mechanisms underlying tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC) are not well understood. We aimed to identify new molecular markers to provide insight into these processes. Methods. This work reports on the identification of human hepatitis A virus cellular receptor 1 (hHAVcr-1) as a differentially expressed gene in ccRCC using RNA-based arbitrarily primed polymerase chain reaction (RAP-PCR). Results were further confirmed by Northern and Western blot assays. Carcinoma 769-P and normal HK-2 cells derived from proximal tubule epithelial cells, grown under different culture conditions, were used to understand the putative role of hHAVcr-1 in renal malignancy. hHAVcr-1 stable transfected clones and dipeptidyl peptidase IV (DPPIV) assays allowed assessing its involvement in cell differentiation. Results. The hHAVcr-1 is overexpressed in eight out of 13 ccRCC and its expression neglected in benign oncocytomas. In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment. Similarly, differentiation prevention by addition of PMA to confluent cells also increases hhavcr-1 expression. hHAVcr-1 stable transfected 769-P cells proved that hhavcr-1 itself blocks differentiation. Since hhavcr-1 is expressed at higher levels in tumor cells, we used an African green monkey cell model to show that immunotoxins directed against the monkey homologue of hhavcr-1 could kill kidney cells. Conclusion. Our results showed that hHAVcr-1 blocks differentiation of proximal tubule epithelial cells and that it could be used as a target for therapy of kidney carcinomas. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - CELL receptors
KW - CELL differentiation
KW - KIDNEY tumors
KW - TUMOR markers
KW - CARCINOGENESIS
N1 - Accession Number: 12767083; Vilà, Maya R. 1 Kaplan, Gerardo G. 1 Feigelstock, Dino 1 Nadal, Margarita 1 Morote, Joan 1 Porta, Ruth 1 Bellmunt, Joaquim 1 Meseguer, Anna 1; Email Address: ameseguer@vhebron.net; Affiliation: 1: Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Barcelona, Spain; Laboratory of Hepatitis and Related Emerging Agents, CBER, Food and Drug Administration, Bethesda, Maryland; Institut de Recerca Oncològica (IRO), Hospital Duran i Reynals, Barcelona, Spain; Servei d'Urologia and Servei d'Oncologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Source Info: May2004, Vol. 65 Issue 5, p1761; Subject Term: HEPATITIS A virus; Subject Term: CELL receptors; Subject Term: CELL differentiation; Subject Term: KIDNEY tumors; Subject Term: TUMOR markers; Subject Term: CARCINOGENESIS; Number of Pages: 13p; Document Type: Article
L3 - 10.1111/j.1523-1755.2004.00601.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schiffenbauer, J.
AU - Simon, L.S.
T1 - Randomized controlled trials in systemic lupus erythematosus: what has been done and what do we need to do?
JO - Lupus
JF - Lupus
Y1 - 2004/05//
VL - 13
IS - 5
M3 - Article
SP - 398
EP - 405
PB - Sage Publications Inc.
SN - 09612033
AB - The study of systemic lupus erythematosus (SLE) is a challenging undertaking. It is difficult to assess outcomes in SLErandomized controlled trials (RCTs), and this is illustrated by the lack of new therapies approved for use in lupus. In a disease that is waxing and waning, and requires constantly changing medications, identifying treatment effects of new therapies may be difficult, and the use of potentially toxic therapies requires a rigorous understanding of the benefit to risk ratio. Some issues that need to be considered by the investigator in designing these studies include: 1)should the trialfocus on patients with active or inactive disease; 2) which of the measures of disease activity should be used or should prevention of flares be examined; 3) should the study focus on defined organ specific endpoints or utilize one of the available disease activity indices to identify changes in disease activity; 4) should the trial be a superiority trial or an equivalence trial. This review summarizes the critical issues involving the design of studies in lupus and provides the reader with suggestions and recommendations for consideration before embarking on trials in this area. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - CLINICAL medicine -- Research
KW - MEDICAL research
KW - SYSTEMIC lupus erythematosus
KW - LUPUS erythematosus
KW - THERAPEUTICS
KW - disease activity indices (DAIs)
KW - DISEASE ACTIVITY INDICES DAIS
KW - flare
KW - HEALTH RELATED QUALITY OF LIFE
KW - health related quality of life (HRQOL)
KW - HRQOL
KW - LUPUS
KW - NONINFERIORITY TRIALS
KW - RANDOMIZED CONTROLLED TRIALS (RCTS)
N1 - Accession Number: 13233958; Schiffenbauer, J. 1; Email Address: schiffenbaue@cder.fda.gov Simon, L.S. 2; Affiliation: 1: Food and Drug Administration, CDER, Rockville, MD 20850, USA 2: Harvard Medical School, Boston, MA 02115, USA; Source Info: 2004, Vol. 13 Issue 5, p398; Subject Term: CLINICAL trials; Subject Term: CLINICAL medicine -- Research; Subject Term: MEDICAL research; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: LUPUS erythematosus; Subject Term: THERAPEUTICS; Author-Supplied Keyword: disease activity indices (DAIs); Author-Supplied Keyword: DISEASE ACTIVITY INDICES DAIS; Author-Supplied Keyword: flare; Author-Supplied Keyword: HEALTH RELATED QUALITY OF LIFE; Author-Supplied Keyword: health related quality of life (HRQOL); Author-Supplied Keyword: HRQOL; Author-Supplied Keyword: LUPUS; Author-Supplied Keyword: NONINFERIORITY TRIALS; Author-Supplied Keyword: RANDOMIZED CONTROLLED TRIALS (RCTS); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1191/0961203303lu1033oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cieslak, Theodore J.
AU - Pavlin, Julie A.
AU - Noah, Donald L.
AU - Dire, Daniel J.
AU - Stanek, Scott A.
AU - Kortepeter, Mark G.
AU - Jarrett, David G.
AU - Pastel, Ross H.
AU - Darling, Robert G.
AU - Jacocks, John M.
AU - Hurst, Charles G.
AU - Richards, Barbara A.
AU - Eitzen Jr., Edward M.
T1 - Military Medical Education: Nuclear, Biological, and Chemical Medical Defense Training as a Model for Planners.
JO - Military Medicine
JF - Military Medicine
Y1 - 2004/05//
VL - 169
IS - 5
M3 - Article
SP - 337
EP - 341
PB - AMSUS
SN - 00264075
AB - Tackles issues concerning medical defense training in the U.S. Types of military medical training; Requirements for the training programs; Initiatives launched to promote military defense training.
KW - MILITARY medicine -- Study & teaching
KW - MILITARY education
KW - MILITARY personnel -- United States
KW - MILITARY readiness
KW - MILITARY medicine
KW - UNITED States
N1 - Accession Number: 13126315; Cieslak, Theodore J. 1; Email Address: Ted.Cieslak@amedd.army.mill Pavlin, Julie A. 2 Noah, Donald L. 3 Dire, Daniel J. 4 Stanek, Scott A. 5 Kortepeter, Mark G. 5 Jarrett, David G. 5 Pastel, Ross H. 5 Darling, Robert G. 5 Jacocks, John M. 6 Hurst, Charles G. 7 Richards, Barbara A. 8 Eitzen Jr., Edward M. 9; Affiliation: 1: San Antonio Military Pediatric Center, San Antonio, TX 2: Walter Reed Army Institute of Research, Silver Spring, MD 3: Office of Air Force Surgeon General, Boiling Air Force Base, Washington, DC 4: Fifth Medical Group, United States Army, Birmingham, AL 5: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 6: Armed Forces Radiobiology Research Institute, Bethesda, MD 7: United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 8: United States Food and Drug Administration, Center for Radiologic Devices and Health, Gaithersburg, MD 9: United States Dept of the Health and Human Services, Washington, DC; Source Info: May2004, Vol. 169 Issue 5, p337; Subject Term: MILITARY medicine -- Study & teaching; Subject Term: MILITARY education; Subject Term: MILITARY personnel -- United States; Subject Term: MILITARY readiness; Subject Term: MILITARY medicine; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ravichandran, Veerasamy
AU - Vasquez, Gregory B.
AU - Srivastava, Sudhir
AU - Verma, Mukesh
AU - Petricoin, Emanuel
AU - Lubell, Joshua
AU - Sriram, Ram D.
AU - Barker, Peter E.
AU - Gilliland, Gary L.
T1 - Data standards for proteomics: mitochondrial two-dimensional polyacrylamide gel electrophoresis data as a model system
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2004/05//
VL - 3
IS - 6
M3 - Article
SP - 327
SN - 15677249
AB - Proteomics has emerged as a major discipline that led to a re-examination of the need for consensus and a nationally sanctioned set of proteomics technology standards. Such standards for databases and data reporting may be applied to two-dimensional polyacrylamide gel electrophoresis (2D PAGE) technology as a pilot project for assessing global and national needs in proteomics, and the role of the National Institute of Standards and Technology (NIST) and other similar standards and measurement organizations. The experience of harmonizing the heterogeneous data included in the Protein Data Bank (PDB) provides a paradigm for technology in an area where significant heterogeneity in technical detail and data storage has evolved. Here we propose an approach toward standardizing mitochondrial 2D PAGE data in support of a globally relevant proteomics consensus. [Copyright &y& Elsevier]
AB - Copyright of Mitochondrion is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - POLYACRYLAMIDE
KW - GEL electrophoresis
KW - DATABASES
KW - TECHNOLOGY
KW - 2D gel electrophoresis
KW - Data standards
KW - Data uniformity
KW - Interoperability
KW - Proteomics
N1 - Accession Number: 12895736; Ravichandran, Veerasamy 1; Email Address: vravi@nist.gov Vasquez, Gregory B. 1 Srivastava, Sudhir 2 Verma, Mukesh 2 Petricoin, Emanuel 3 Lubell, Joshua 4 Sriram, Ram D. 4 Barker, Peter E. 1 Gilliland, Gary L. 1; Affiliation: 1: Biotechnology Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA 2: Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852, USA 3: Division of Therapeutic Products, Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA 4: Manufacturing Systems Integration Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA; Source Info: May2004, Vol. 3 Issue 6, p327; Subject Term: PROTEOMICS; Subject Term: POLYACRYLAMIDE; Subject Term: GEL electrophoresis; Subject Term: DATABASES; Subject Term: TECHNOLOGY; Author-Supplied Keyword: 2D gel electrophoresis; Author-Supplied Keyword: Data standards; Author-Supplied Keyword: Data uniformity; Author-Supplied Keyword: Interoperability; Author-Supplied Keyword: Proteomics; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mito.2004.02.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bernstein, Ralph M.
AU - Mills, Frederick C.
AU - Mitchell, Mary
AU - Max, Edward E.
T1 - Complex mechanisms for inhibition of immunoglobulin gene expression in a germinal center B cell line
JO - Molecular Immunology
JF - Molecular Immunology
Y1 - 2004/05//
VL - 41
IS - 1
M3 - Article
SP - 63
EP - 72
SN - 01615890
AB - CD40 ligation and IL-4 stimulation are critical Th2 cell-derived signals that act on germinal center B cells to stimulate immunoglobulin isotype switching. In addition to this well-known effect, these same Th2 signals have also been reported to inhibit ongoing immunoglobulin synthesis in germinal center B cells. To study the mechanism of this inhibition, we have investigated which immunoglobulin gene regulatory regions might be affected by IL-4 and CD40 Ligand (CD40L). CL-01 cells, a human B cell line of germinal center phenotype, were transiently transfected with luciferase reporter constructs containing various light and heavy chain enhancers and promoters; the cells were then incubated with or without CD40L and IL-4 and then assayed for luciferase expression. We find that the intronic enhancer of the κ light chain (but not the heavy chain) is upregulated by CD40 ligation, but that VH and Vκ promoters and the 3′ enhancers of both the κ and heavy chain loci are inhibited by CD40 ligation and the Th2 cytokines IL-4 and IL-10. The inhibitory response of the 3′α enhancer can be observed with a 130 bp core fragment of the enhancer, and remains unaffected by mutations in several motifs known or suspected to contribute to enhancer function. The ultimate effects of cytokines and CD40 ligation on immunoglobulin gene transcription therefore represent a complex integration of positive and negative stimuli acting on enhancers and promoters. [Copyright &y& Elsevier]
AB - Copyright of Molecular Immunology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - GENE expression
KW - B cells
KW - CYTOKINES
KW - Antibodies
KW - B lymphocytes
KW - Cytokines
KW - Gene regulation
KW - Human
N1 - Accession Number: 13106732; Bernstein, Ralph M. 1 Mills, Frederick C. 1 Mitchell, Mary 1 Max, Edward E.; Email Address: max@cber.fda.gov; Affiliation: 1: Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-541, Bethesda, MD 20892, USA; Source Info: May2004, Vol. 41 Issue 1, p63; Subject Term: IMMUNOGLOBULINS; Subject Term: GENE expression; Subject Term: B cells; Subject Term: CYTOKINES; Author-Supplied Keyword: Antibodies; Author-Supplied Keyword: B lymphocytes; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: Gene regulation; Author-Supplied Keyword: Human; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.molimm.2004.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delogu, Giovanni
AU - Pusceddu, Cinzia
AU - Bua, Alessandra
AU - Fadda, Giovanni
AU - Brennan, Michael J.
AU - Zanetti, Stefania
T1 - Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2004/05//
VL - 52
IS - 3
M3 - Article
SP - 725
EP - 733
PB - Wiley-Blackwell
SN - 0950382X
AB - Identification of the novel PE multigene family was an unexpected finding of the genomic sequencing of Mycobacterium tuberculosis. Presently, the biological role of the PE and PE_PGRS proteins encoded by this unique family of mycobacterial genes remains unknown. In this report, a representative PE_PGRS gene (Rv1818c/PE_PGRS33) was selected to investigate the role of these proteins. Cell fractionation studies and fluorescence analysis of recombinant strains of Mycobacterium smegmatis and M. tuberculosis expressing green fluorescent protein (GFP)-tagged proteins indicated that the Rv1818c gene product localized in the mycobacterial cell wall, mostly at the bacterial cell poles, where it is exposed to the extracellular milieu. Further analysis of this PE_PGRS protein showed that the PE domain is necessary for subcellular localization. In addition, the PGRS domain, but not PE, affects bacterial shape and colony morphology when Rv1818c is overexpressed in M. smegmatis and M. tuberculosis. Taken together, the results indicate that PE_PGRS and PE proteins can be associated with the mycobacterial cell wall and influence cellular structure as well as the formation of mycobacterial colonies. Regulated expression of PE genes could have implications for the survival and pathogenesis of mycobacteria within the human host and in other environmental niches. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIAL diseases
KW - MYCOBACTERIUM
KW - MYCOBACTERIUM tuberculosis
KW - BIOMOLECULES
KW - GREEN fluorescent protein
KW - GENES
KW - HEREDITY
KW - FLUORIMETRY
KW - PROTEINS
N1 - Accession Number: 12867072; Delogu, Giovanni 1,2; Email Address: gdelogu@rm.unicatt.it Pusceddu, Cinzia 1 Bua, Alessandra 1 Fadda, Giovanni 3 Brennan, Michael J. 4 Zanetti, Stefania 1; Affiliation: 1: Department of Biomedical Sciences, University of Sassari, Italy 2: Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Roma, Italy 3: Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy 4: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: May2004, Vol. 52 Issue 3, p725; Subject Term: MYCOBACTERIAL diseases; Subject Term: MYCOBACTERIUM; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: BIOMOLECULES; Subject Term: GREEN fluorescent protein; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: FLUORIMETRY; Subject Term: PROTEINS; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1365-2958.2004.04007.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chelonis, John J.
AU - Flake, Rebecca A.
AU - Baldwin, Ronald L.
AU - Blake, Donna J.
AU - Paule, Merle G.
T1 - Developmental aspects of timing behavior in children
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2004/05//
VL - 26
IS - 3
M3 - Article
SP - 461
SN - 08920362
AB - This research examined the association of age, sex, and intelligence on the performance of a time production (temporal response differentiation, TRD) task. Variations of this task have been used extensively with both animals and humans to study factors that affect aspects of timing ability. The participants in this study (720 children, ages 5 to 13 years) were required to hold down a response lever for at least 10 s, but no more than 14 s, to receive a nickel. Older children made more correct lever holds and exhibited less variability in the duration of their lever holds than did the younger children. Boys and girls performed similarly on this task, whereas children with higher IQs made more correct lever holds. Young children with below average IQs exhibited increased variability in lever hold duration compared with young children with average and above average IQs. The results of this study illustrate that both age and intelligence influence timing ability. The use of this timing task in children, which also has been widely used in animal models, provides unique opportunities for interspecies comparisons. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TIME perception -- Experiments
KW - INTELLIGENCE levels
KW - EDUCATIONAL psychology
KW - GIFTED children
KW - Age
KW - Children
KW - Intelligence
KW - Sex
KW - Temporal response differentiation
KW - Time production
KW - Timing
N1 - Accession Number: 12899082; Chelonis, John J. 1,2,3; Email Address: JJChelonis@UALR.edu Flake, Rebecca A. 1 Baldwin, Ronald L. 2 Blake, Donna J. 2 Paule, Merle G. 2,3; Affiliation: 1: Department of Psychology, University of Arkansas at Little Rock, 2801 South University Ave., Little Rock, AR 72204, USA 2: University of Arkansas for Medical Sciences—Arkansas Children's Hospital, USA 3: National Center for Toxicological Research, USA; Source Info: May2004, Vol. 26 Issue 3, p461; Subject Term: TIME perception -- Experiments; Subject Term: INTELLIGENCE levels; Subject Term: EDUCATIONAL psychology; Subject Term: GIFTED children; Author-Supplied Keyword: Age; Author-Supplied Keyword: Children; Author-Supplied Keyword: Intelligence; Author-Supplied Keyword: Sex; Author-Supplied Keyword: Temporal response differentiation; Author-Supplied Keyword: Time production; Author-Supplied Keyword: Timing; NAICS/Industry Codes: 611710 Educational Support Services; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.ntt.2004.01.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kovalchuk, Igor
AU - Abramov, Vladimir
AU - Pogribny, Igor
AU - Kovalchuk, Olga
T1 - Molecular Aspects of Plant Adaptation to Life in the Chernobyl Zone.
JO - Plant Physiology
JF - Plant Physiology
Y1 - 2004/05//
VL - 135
IS - 1
M3 - Article
SP - 357
EP - 363
SN - 00320889
AB - With each passing year since the Chernobyl accident of 1986, more questions arise about the potential for organisms to adapt to radiation exposure. Often this is thought to be attributed to somatic and germline mutation rates in various organisms. We analyzed the adaptability of native Arabidopsis plants collected from areas with different levels of contamination around the Chernobyl nuclear power plant from 1986 to 1992. Notably, progeny of Chernobyl plants resisted higher concentrations of the mutagens Rose Bengal and methyl methane sulfonate. We analyzed the possible molecular mechanisms of their resistance to mutagens and found a more than 10-fold lower frequency of extrachromosomal homologous recombination, significant differences in the expression of radical scavenging (CAT1 and FSD3) and DNA-repair (RAD1 and RAD51-1ike) genes upon exposure to mutagens (Rose Bengal and x-rays), and a higher level of global genome methylation. This data suggests that adaptation to ionizing radiation is a complex process involving epigenetic regulation of gene expression and genome stabilization that improves plants' resistance to environmental mutagens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Plant Physiology is the property of American Society of Plant Physiologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLANTS -- Adaptation
KW - MUTATION (Biology)
KW - RADIATION
KW - MUTAGENESIS
KW - GENETICS
KW - ARABIDOPSIS
KW - NUCLEIC acids
KW - GENETIC regulation
KW - CHORNOBYL (Ukraine)
KW - UKRAINE
N1 - Accession Number: 13354370; Kovalchuk, Igor 1 Abramov, Vladimir 2 Pogribny, Igor 3 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4 2: Vavilov Institute of General Genetics, Russian Academy of Sciences, 117809 Moscow, Russia 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; Source Info: May2004, Vol. 135 Issue 1, p357; Subject Term: PLANTS -- Adaptation; Subject Term: MUTATION (Biology); Subject Term: RADIATION; Subject Term: MUTAGENESIS; Subject Term: GENETICS; Subject Term: ARABIDOPSIS; Subject Term: NUCLEIC acids; Subject Term: GENETIC regulation; Subject Term: CHORNOBYL (Ukraine); Subject Term: UKRAINE; Number of Pages: 7p; Illustrations: 2 Black and White Photographs, 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1104/pp.104.040477
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Satterfield, Dawn W.
AU - Murphy, Dara
AU - Hosey, Gwen
AU - Stankus, Melissa
AU - Hoffman, Pete
AU - Beartusk, Kaetz
AU - Mitchell, Patricia L.
AU - Alfaro-Correa, Ana
AU - Essien, Joyce D. K.
T1 - Using the Essential Public Health Services as Strategic Leverage to Strengthen the Public Health Response to Diabetes.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2004/05//May/Jun2004
VL - 119
IS - 3
M3 - Article
SP - 311
EP - 321
SN - 00333549
AB - If current trends continue, health systems will soon be overwhelmed by type 2 diabetes mellitus. Successful population-based diabetes prevention and control efforts require a sound and continually improving infrastructure. In states and U.S. territories, the Diabetes Prevention and Control Programs supported by the U.S. Centers for Disease Control and Prevention's Division of Diabetes Translation serve as a fulcrum for building and refining the infrastructure that links diverse and dynamic partners dedicated to increasing the years and quality of life and achieving health equity among people with and at risk for diabetes. The National Public Health Performance Standards offer a conceptual framework that articulates the requisite infrastructure and services provided by an interconnected network of intersectoral partners to strengthen the public health response to diabetes. These standards associated with the Essential Public Health Services are valuable tools to assess the status of the performance of the health system's infrastructure to guide improvement. The process of engaging system partners in a system-wide assessment informs and leverages cross-sectoral assets to improve health outcomes for citizens in communities shouldering the growing burden of diabetes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - DIABETES
KW - PREVENTIVE medicine
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 13635986; Satterfield, Dawn W. 1; Email Address: dxs9@cdc.gov Murphy, Dara 1 Hosey, Gwen 1 Stankus, Melissa 1 Hoffman, Pete 1 Beartusk, Kaetz 1 Mitchell, Patricia L. 1 Alfaro-Correa, Ana 1 Essien, Joyce D. K. 2,3; Affiliation: 1: Program Development Branch, Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA 2: Commissioned Health Officer, Public Health Service, Public Health Practice Program Office, Centers for Disease Control and Prevention 3: Center for Public Health Practice, Rollins School of Public Health, Emory University, Atlanta, GA; Source Info: May/Jun2004, Vol. 119 Issue 3, p311; Subject Term: PUBLIC health; Subject Term: DIABETES; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Illustrations: 2 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schachter, E. Neil
AU - Zuskin, Eugenija
AU - Rienzi, Nicholas
AU - Goswami, Satindra
AU - Castranova, Vincent
AU - Siegel, Paul
AU - Whitmer, Michael
AU - Chung, Eric
T1 - Pharmacological Studies of the Effect of Wheat Grain Extract.
JO - Respiration
JF - Respiration
Y1 - 2004/05//May/Jun2004
VL - 71
IS - 3
M3 - Article
SP - 276
EP - 283
SN - 00257931
AB - Background: Agricultural farm workers exposed to wheat grain dust are at risk of developing respiratory abnormalities. The pathogenesis of this injury is only partially understood. Objectives: To determine the effect of wheat grain extract on isolated guinea pig tracheal smooth muscle. Methods: In the current study, pharmacologic properties of wheat grain extract (WGE) were tested using guinea pig tracheas studied in vitro. Dose-related contractions of nonsensitized guinea pig trachea were demonstrated using these extracts. Pharmacologic studies were performed by pretreating guinea pig tracheal tissue with drugs known to modulate smooth muscle contraction: atropine 10-6 M, indomethacin 10-6 M, pyrilamine 10-6 M, acivicin 10-5 M, nordihydroguaretic acid (NDGA) 10-5 M, bromophenacyl bromide (BPB) 10-5 M, 3,4,5-trimethoxybenzoic acid-8-(diethylamino)-octyl ester TMB8 10-5 M, captopril 10-5 M and capsaicin 5 x 10-6 M. Results: WGE causes a dose-dependent constriction of guinea pig tracheal smooth muscle. Atropine, pyrilamine, TMB8 and acivicin significantly reduced the contractile effects of the WGE. Inhibition of contraction by blocking of other mediators was significant but less complete. Conclusion: We conclude that WGE causes a dose-related constriction of airway smooth muscle by nonimmunological mechanisms involving a variety of airway mediators and possibly cholinergic receptors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Respiration is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WHEAT
KW - GRAIN
KW - GUINEA pigs as laboratory animals
KW - TRACHEA
KW - PHYSIOLOGY
KW - Guinea pig trachea
KW - Wheat grain extract
N1 - Accession Number: 20716146; Schachter, E. Neil 1; Email Address: neil.schachter@mssm.edu Zuskin, Eugenija 2 Rienzi, Nicholas 1 Goswami, Satindra 1 Castranova, Vincent 3 Siegel, Paul 3 Whitmer, Michael 3 Chung, Eric 3; Affiliation: 1: The Mount Sinai School of Medicine, New York, N.Y., USA 2: Andrija Stampar School of Public Health, Zagreb, Croatia, USA 3: The National Institute of Occupational Safety and Health, Morgantown, W.Va., USA; Source Info: May/Jun2004, Vol. 71 Issue 3, p276; Subject Term: WHEAT; Subject Term: GRAIN; Subject Term: GUINEA pigs as laboratory animals; Subject Term: TRACHEA; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: Guinea pig trachea; Author-Supplied Keyword: Wheat grain extract; NAICS/Industry Codes: 111190 Other grain farming; NAICS/Industry Codes: 484232 Dry bulk materials trucking, long distance; NAICS/Industry Codes: 484222 Dry bulk materials trucking, local; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 312120 Breweries; NAICS/Industry Codes: 311214 Rice milling and malt manufacturing; NAICS/Industry Codes: 111191 Oilseed and Grain Combination Farming; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 311211 Flour Milling; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; NAICS/Industry Codes: 111140 Wheat Farming; Number of Pages: 8p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1159/000077426
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moncada, Jeanne
AU - Schachter, Julius
AU - Hook III, Edward W.
AU - Ferrero, Dennis
AU - Gaydos, Charlotte
AU - Quinn, Thomas C.
AU - Willis, Dean
AU - Weissfeld, Alice
AU - Martin, David H.
T1 - The Effect of Urine Testing in Evaluations of the Sensitivity of the Gen-Probe APTIMA® Combo 2 Assay on Endocervical Swabs for Chlamydia trachomatis and Neisseria gonorrhoeae.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2004/05//
VL - 31
IS - 5
M3 - Article
SP - 273
EP - 277
SN - 01485717
AB - The Gen-Probe APTIMA Combo 2 (AC2) assay is a second-generation transcription-mediated amplification assay for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). The goal of this study was to evaluate AC2 performance of endocervical (cx) swabs for the detection of CT and NG using either a specimen or an infected patient standard. In a multicenter clinical study, we compared AC2 with Abbott's ligase chain reaction (LCR) and Roche's polymerase chain reaction (PCR; Amplicor or COBAS) for CT, and we compared AC2 with Abbott's LCR and culture for NG. A total of 1569 females were enrolled in the study; we collected cx and first-catch urine (FCU) specimens. CT prevalence was 13.3% for cx specimens and 13.7% for FCU specimens. NG prevalence was 8.7% and 7.9% for cx and FCU specimens, respectively. When based only on cx specimens, AC2, LCR, and PCR sensitivities for CT were 99.4%, 95.6%, and 95.6%, respectively. However, cx sensitivity for CT was reduced to 92.1%, 86.6%, and 87.1% for each respective assay when based on both cx and FCU specimen results (infected patient standard). NG sensitivities for AC2, LCR, and culture based solely on cx specimen results were 99.2%, 96.1%, and 85.9%, respectively. Based on infected patient standard, the sensitivities of each respective assay were 98.5%, 93.9%, and 84.0%. The infected patient standard reduces the sensitivity of the endocervical evaluation because some infected patients are positive only with FCU. The reduction in sensitivity is greater when testing for CT. Specificities improved slightly, because some unique cx positives, initially classified as false-positive were confirmed by a positive FCU result. Sensitivity of AC2 was higher than LCR, PCR, and culture. Specificity was slightly lower, but discrepant analysis (using alternate TMA targets) of apparent AC2 false-positives showed that 75% to 80% were true-positives. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Diseases is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINALYSIS
KW - CLINICAL pathology
KW - MOLECULAR probes -- Diagnostic use
KW - SWABS (Surgery)
KW - CHLAMYDIA trachomatis
KW - NEISSERIA gonorrhoeae
KW - SEXUALLY transmitted diseases
KW - PUBLIC health
N1 - Accession Number: 13152967; Moncada, Jeanne 1; Email Address: jevemo@itsa.ucsf.edu Schachter, Julius 1 Hook III, Edward W. 2 Ferrero, Dennis 3 Gaydos, Charlotte 4 Quinn, Thomas C. 4 Willis, Dean 5 Weissfeld, Alice 6 Martin, David H. 7; Affiliation: 1: University of California, San Francisco, California 2: University of Alabama, Birmingham, Alabama 3: San Joaquin County Public Health Service, Stockton, California 4: Johns Hopkins University, Baltimore, Maryland 5: Florida Department of Heath, Jacksonville, Florida 6: Microbiology Specialist Inc., Houston, Texas 7: Louisiana State University, New Orleans, Louisiana; Source Info: May2004, Vol. 31 Issue 5, p273; Subject Term: URINALYSIS; Subject Term: CLINICAL pathology; Subject Term: MOLECULAR probes -- Diagnostic use; Subject Term: SWABS (Surgery); Subject Term: CHLAMYDIA trachomatis; Subject Term: NEISSERIA gonorrhoeae; Subject Term: SEXUALLY transmitted diseases; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
L3 - 10.1097/01.OLQ.0000124611.73009.D5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13152967&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duncan, Robert
T1 - DNA microarray analysis of protozoan parasite gene expression: outcomes correlate with mechanisms of regulation
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2004/05//
VL - 20
IS - 5
M3 - Article
SP - 211
SN - 14714922
AB - DNA microarray analysis has been successfully applied to most of the protozoan parasites that cause human disease, but has not made equal progress in all cases. The results for kinetoplastid parasites (Leishmania and Trypanosoma) are primarily at the stage of validation and new gene discovery. By contrast, the results for apicomplexan parasites (Plasmodium and Toxoplasma) have advanced to the analysis of coordinate regulation of clusters of genes. This difference in progress relates to the more complete genome sequence identified for the apicomplexans and, more significantly, to the differences in the regulation of gene expression between these two groups. [Copyright &y& Elsevier]
AB - Copyright of Trends in Parasitology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - PROTOZOA
KW - PARASITES
KW - PROTOZOAN diseases
KW - LEISHMANIA
KW - TRYPANOSOMA
N1 - Accession Number: 12895752; Duncan, Robert 1; Email Address: duncan@cber.fda.gov; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 1401 Rockville Pk, Rockville, MD 20852, USA; Source Info: May2004, Vol. 20 Issue 5, p211; Subject Term: DNA microarrays; Subject Term: PROTOZOA; Subject Term: PARASITES; Subject Term: PROTOZOAN diseases; Subject Term: LEISHMANIA; Subject Term: TRYPANOSOMA; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.pt.2004.02.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Henry, Alexis D.
AU - Lucca, Anna M.
T1 - Facilitators and barriers to employment: The perspectives of people with psychiatric disabilities and employment service providers.
JO - Work
JF - Work
Y1 - 2004/05//
VL - 22
IS - 3
M3 - Article
SP - 169
EP - 182
PB - IOS Press
SN - 10519815
AB - This study examined the perspectives of people with psychiatric disabilities and employment service providers regarding factors that most directly help or hinder consumer efforts to obtain and maintain employment. Forty-four adults with serious mental illness (SMI) (consumers) and 30 providers participated in 12 focus groups across Massachusetts. We began both consumer and provider groups by posing two broad questions: 1) what factors most help people with SMI get and keep jobs (facilitators), and 2) what factors most prevent people with SMI from getting and keeping jobs (barriers)? Data were analyzed qualitatively and both person and environmental factors were highlighted. Among facilitators, participants agreed that quality consumer-provider relationships and individualized employment services are most instrumental in helping consumers achieve employment goals. Participants identified a range of environmental barriers, including issues related to the service system, entitlement programs, non-human resources, and social stigma. Implications for services are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Work is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - People with disabilities -- Employment
KW - People with disabilities -- Vocational guidance
KW - Mentally ill -- Employment
KW - Employment (Economic theory)
KW - Employment agencies
N1 - Accession Number: 13121218; Henry, Alexis D. 1,2; Email Address: alexis.henry@umassmed.edu.; Lucca, Anna M. 3; Affiliations: 1: Department of Rehabilitation Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, USA; 2: Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, USA; 3: The Lewin Group, Falls Church, VA, USA; Issue Info: 2004, Vol. 22 Issue 3, p169; Subject Term: People with disabilities -- Employment; Subject Term: People with disabilities -- Vocational guidance; Subject Term: Mentally ill -- Employment; Subject Term: Employment (Economic theory); Subject Term: Employment agencies; NAICS/Industry Codes: 561311 Employment Placement Agencies; NAICS/Industry Codes: 561310 Employment placement agencies and executive search services; NAICS/Industry Codes: 912210 Provincial labour and employment services; NAICS/Industry Codes: 911310 Federal labour and employment services; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 14p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2004-15362-007
AN - 2004-15362-007
AU - Johnson, Elizabeth Anne
AU - O'Callaghan, James P.
AU - Miller, Diane B.
T1 - Brain concentrations of d-MDMA are increased after stress.
T3 - MDMA (ecstasy)
JF - Psychopharmacology
JO - Psychopharmacology
JA - Psychopharmacology (Berl)
Y1 - 2004/05//
VL - 173
IS - 3-4
SP - 278
EP - 286
CY - Germany
PB - Springer
SN - 0033-3158
SN - 1432-2072
AD - Johnson, Elizabeth Anne, Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Mailstop 3014, Morgantown, VA, US
N1 - Accession Number: 2004-15362-007. PMID: 14735292 Other Journal Title: Psychopharmacologia. Partial author list: First Author & Affiliation: Johnson, Elizabeth Anne; Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health/Centers for Disease Control, Morgantown, VA, US. Release Date: 20040705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Dopamine; Hippocampus; Methylenedioxymethamphetamine; Stress. Minor Descriptor: Concentration; Hyperthermia; Mice; Psychopharmacology; Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2004.
AB - In the mouse but not the rat, d-3,4-methylenedioxymethamphetamine (d-MDMA) is a dopaminergic neurotoxicant. Various stressors and hypothermia protect against d-MDMA-induced neurotoxicity through unknown mechanisms, one of which could be a reduction in the distribution of d-MDMA to the brain. We determined striatal levels of d-MDMA in relation to body temperature in mice exposed to a neurotoxic regimen of d-MDMA in the presence or absence of various stressors. Female C57BL6/J mice received a neurotoxic regimen of d-MDMA (15.0 mg/kg s.c. as the base every 2 hx4) alone or in combination with manipulations with a known neuroprotective status. Levels of dopamine, tyrosine hydroxylase and GFAP were used to assess neurotoxicity. Restraint, ethanol co-treatment and cold stress were neuroprotective, caused hypothermia and increased striatal d-MDMA levels by 4- to 7-fold. Corticosterone treatment, as a stress mimic, did not alter striatal d-MDMA or temperature and was not protective. Although stress and other protective manipulations can alter the striatal concentration of d- MDMA their hypothermia-inducing properties appear a more likely determinant of their neuroprotection against the striatal dopaminergic neurotoxicity of d-MDMA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ecstasy
KW - MDMA
KW - dopaminergic neurotoxicity
KW - stress
KW - hypothermia
KW - striatal glutamate receptor antagonist
KW - corticosterone treatment
KW - brain concentrations
KW - cold stress
KW - 3
KW - 4- methylenedioxymethamphetamine
KW - 2004
KW - Brain
KW - Dopamine
KW - Hippocampus
KW - Methylenedioxymethamphetamine
KW - Stress
KW - Concentration
KW - Hyperthermia
KW - Mice
KW - Psychopharmacology
KW - Rats
KW - 2004
DO - 10.1007/s00213-003-1740-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15362-007&site=ehost-live&scope=site
UR - EDJ2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-14024-006
AN - 2004-14024-006
AU - Becker, Julie
AU - Kovach, Andrea Crivelli
AU - Gronseth, Dickie Lynn
T1 - Individual Empowerment: How Community Health Workers Operationalize Self-Determination, Self-Sufficiency, and Decision-Making Abilities of Low-Income Mothers.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2004/05//
VL - 32
IS - 3
SP - 327
EP - 342
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Kovach, Andrea Crivelli, Department of Medical Science and Community Health, Arcadia University, 450 South Easton Road, Glenside, PA, US, 19038
N1 - Accession Number: 2004-14024-006. Partial author list: First Author & Affiliation: Becker, Julie; Public Health Consultants, US. Release Date: 20040705. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Decision Making; Empowerment; Mothers; Self-Determination. Minor Descriptor: Lower Income Level; Community Health. Classification: Community & Social Services (3373). Population: Human (10); Female (40). Location: US. Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: May, 2004.
AB - The purposes of this study were to operationalize individual empowerment within the context of the MOMobile Program, to explore the relationships formed between MOMobile Advocates and their clients, and to develop an appropriate survey instrument for assessing the impact of a Community Health Worker (CHW) intervention in a community-based social service agency. Phase 1 of a multiphase study used focus group interviews with MOMobile Advocates to operationalize empowerment, define their professional roles, and explore the relationships formed with their clients. This article focuses specifically on operationalizing individual empowerment and describing the relationships formed between the Advocates and their clients. Three major themes emerged: (1) the importance of relationships established between Advocates and their clients, (2) the resources available to the clients, and (3) the ability of Advocates to become change agents for their clients. The Community Health Worker (CHW) model is effective for health promotion in disadvantaged communities. MOMobile Advocates improve quality of life by fostering better patient-provider communication, continuity of care,and help-seeking behavior and by expanding the women's social support systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - individual empowerment
KW - community health workers
KW - self sufficiency
KW - self determination
KW - decision making
KW - low income mothers
KW - 2004
KW - Community Services
KW - Decision Making
KW - Empowerment
KW - Mothers
KW - Self-Determination
KW - Lower Income Level
KW - Community Health
KW - 2004
DO - 10.1002/jcop.20000
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-14024-006&site=ehost-live&scope=site
UR - kovach@arcadia.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15581-005
AN - 2004-15581-005
AU - Foley, Daniel
AU - Ancoli-Israel, Sonia
AU - Britz, Patricia
AU - Walsh, James
T1 - Sleep disturbances and chronic disease in older adults: Results of the 2003 National Sleep Foundation Sleep in America Survey.
JF - Journal of Psychosomatic Research
JO - Journal of Psychosomatic Research
JA - J Psychosom Res
Y1 - 2004/05//
VL - 56
IS - 5
SP - 497
EP - 502
CY - Netherlands
PB - Elsevier Science
SN - 0022-3999
AD - Foley, Daniel, Substance Abuse and Mental Health Services Administration, Department of Health and Human Services, 5600 Fishers Lane, Room 15C-04, Rockville, MD, US, 20857
N1 - Accession Number: 2004-15581-005. PMID: 15172205 Partial author list: First Author & Affiliation: Foley, Daniel; Substance Abuse and Mental Health Services Administration, Department of Health and Human Services, Rockville, MD, US. Release Date: 20040705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Chronic Illness; Comorbidity; Sleep Disorders; Surveys. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: May, 2004.
AB - The objective of the study is to assess the association between sleep problems and chronic disease in older adults. Self-reported standardized questionnaire data from 1506 community-dwelling men and women aged 55-84 years in the continental United States who completed a 20-min telephone interview when contacted from lists of randomly selected telephone numbers. The results stated that a majority of the participants (83%) reported one or more of 11 medical conditions and nearly one in four elderly respondents (age 65-84 years) had major comorbidity. Depression, heart disease, bodily pain and memory problems were associated with more prevalent symptoms of insomnia. Other conditions such as obesity, arthritis, diabetes, lung diseases, stroke and osteoporosis were associated with other sleep-related problems such as breathing pauses, snoring, daytime sleepiness, restless legs or insufficient sleep (<6 h nightly). It was concluded that poll findings are consistent with epidemiological studies of sleep, aging and chronic disease. These results suggest that the sleep complaints common in older adults are often secondary to their comorbidities and not to aging per se. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sleep disturbances
KW - chronic disease
KW - older adults
KW - comorbidities
KW - sleep problems
KW - Sleep in American survey
KW - 2004
KW - Aging
KW - Chronic Illness
KW - Comorbidity
KW - Sleep Disorders
KW - Surveys
KW - 2004
DO - 10.1016/j.jpsychores.2004.02.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15581-005&site=ehost-live&scope=site
UR - foleyd@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Strickland, Bonnie
AU - McPherson, Merle
AU - Weissman, Gloria
AU - Van Dyck, Peter
AU - Zhihuan J. Huang, Peter
AU - Newacheck, Paul
T1 - Access to the Medical Home: Results of the National Survey of Children With Special Health Care Needs.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/05/02/May2004 Supplement
VL - 113
M3 - Article
SP - 1485
EP - 1492
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. The purpose of this article is to report the findings of the National Survey of Children With Special Health Care Needs regarding parent per-ceptions of the extent to which children with special health care needs (CSHCN) have access to a medical home. Methods. Five criteria, selected to reflect the charac-teristics of a medical home as defined by the American Academy of Pediatrics (AAP) policy statement on the medical home, were analyzed to describe the extent to which CSHCN receive care characteristic of the medical home concept. These criteria included having 1) a usual place for sick/well care, 2) a personal doctor or nurse, 3) no difficulty in obtaining needed referrals, 4) needed care coordination, and 5) family-centered care received. Items from the Survey were selected and clustered to characterize each of the 5 components. Criteria for each item were established with the requirement that the cri-teria must be met for all items in a component to receive credit for the component. Results. Results of the survey indicate that 1) approx-imately half of CSHCN receive care that meets all 5 components established for medical home; 2) most CSHCN have a usual source of care and a personal doctor or nurse, but other components of the medical home, especially elements of care coordination and family-cen-tered care, are lacking; 3) access to a medical home is significantly affected by race/ethnicity, poverty, and the limitations imposed on daily activity by the child's spe-cial health care need; and 4) parents of children who do have a medical home report significantly less delayed or forgone care, significantly fewer unmet health care needs, and significantly fewer unmet needs for family support services. The 5 components described represent major characteristics of the comprehensive care model recommended for all children by the AAP. Conclusions. The findings suggest that although some components of the medical home... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD health services
KW - MEDICAL care -- United States
KW - PEDIATRICS
KW - MEDICAL care surveys
KW - UNITED States
N1 - Accession Number: 12858586; Strickland, Bonnie 1 McPherson, Merle 1 Weissman, Gloria 1 Van Dyck, Peter 1 Zhihuan J. Huang, Peter 2 Newacheck, Paul 3; Affiliation: 1: Maternal and Child Health Bureau Health, Resources and Services Administration, Washington, DC 2: Children's National Medical Center, George Washington University Medical Center, Washington, DC 3: Institute for Health Policy Studies and Department of Pediatrics, University of California at San Francisco, San Francisco, California; Source Info: May2004 Supplement, Vol. 113, p1485; Subject Term: CHILD health services; Subject Term: MEDICAL care -- United States; Subject Term: PEDIATRICS; Subject Term: MEDICAL care surveys; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McPherson, Merle
AU - Weissman, Gloria
AU - Strickland, Bonnie B.
AU - Van Dyck, Peter C.
AU - Blumberg, Stephen J.
AU - Newacheck, Paul W.
T1 - Implementing Community-Based Systems of Services for Children and Youths With Special Health Care Needs: How Well Are We Doing?
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/05/02/May2004 Supplement
VL - 113
M3 - Article
SP - 1538
EP - 1544
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. To provide a baseline mea-sure of the proportion of US children who meet the Maternal and Child Health Bureau's core outcomes for children with special health care needs (CSHCN). Those core outcomes include the following: 1) families of CSHCN will partner in decision making and will be satisfied with the services that they receive; 2) CSHCN will receive coordinated, ongoing comprehensive care within a medical home; 3) families of CSHCN will have adequate private and/or public insurance to pay for the services that they need; 4) children will be screened early and continuously for special health care needs; 5) com-munity- based service systems will be organized so that families can use them easily; and 6) youths with special health care needs will receive the services necessary to make transitions to adult life, including adult health care, work, and independence. Methods. A national household survey was con-ducted using telephone interviews. We analyzed data on 38 866 CSHCN included in the 2001 National Survey of CSHCN and 13 579 children included in the 2001 Na-tional Health Interview Survey. We assessed the propor-tion of US children who met each of the 6 core outcomes for CSHCN using data from 2 surveys. Results. Success rates ranged from 6% (the core out-come on successful transition to adulthood) to 74% (the core outcome on organization of the service system). For 5 of the 6 core outcomes, success rates exceeded 50%. Conclusion. Our results indicate that, for the most part, the United States is well positioned to meet the 6 core outcomes. However, much more work lies ahead before success can be claimed. This is especially true for the core outcome on transition to adulthood, for which only 6% of children in the target population are now meeting this goal. Pediatrics 2004;113:1538 --1544; children with special health care needs, children, chronic illness, access, insurance, medical home. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - PEDIATRICS
KW - MEDICAL care -- United States
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 12859073; McPherson, Merle 1; Email Address: mmcpherson@hrsa.gov Weissman, Gloria 1 Strickland, Bonnie B. 1 Van Dyck, Peter C. 1 Blumberg, Stephen J. 2 Newacheck, Paul W. 3; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 3: Institute for Health Policy Studies and Department of Pediatrics, University of California at San Francisco, San Francisco, California; Source Info: May2004 Supplement, Vol. 113, p1538; Subject Term: CHILDREN -- Health; Subject Term: PEDIATRICS; Subject Term: MEDICAL care -- United States; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106611800
T1 - Access to the medical home: results of the National Survey of Children With Special Health Care Needs.
AU - Strickland B
AU - McPherson M
AU - Weissman G
AU - van Dyck P
AU - Huang ZJ
AU - Newacheck P
Y1 - 2004/05/03/2004 May Supplement
N1 - Accession Number: 106611800. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2004 May Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: National Survey of Children With Special Health Care Needs. NLM UID: 0376422.
KW - Child Health Services
KW - Child, Disabled
KW - Health Services Accessibility -- In Infancy and Childhood
KW - Primary Health Care -- In Infancy and Childhood
KW - Child
KW - Chronic Disease -- In Infancy and Childhood
KW - Female
KW - Interviews
KW - Male
KW - Parents
KW - Patient Centered Care -- In Infancy and Childhood
KW - Pediatrics -- Standards
KW - Questionnaires
KW - Surveys
KW - Telephone
KW - United States
KW - Human
SP - 1485
EP - 1492
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
IS - 5 Part 2
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: The purpose of this article is to report the findings of the National Survey of Children With Special Health Care Needs regarding parent perceptions of the extent to which children with special health care needs (CSHCN) have access to a medical home. METHODS: Five criteria, selected to reflect the characteristics of a medical home as defined by the American Academy of Pediatrics (AAP) policy statement on the medical home, were analyzed to describe the extent to which CSHCN receive care characteristic of the medical home concept. These criteria included having 1) a usual place for sick/well care, 2) a personal doctor or nurse, 3) no difficulty in obtaining needed referrals, 4) needed care coordination, and 5) family-centered care received. Items from the Survey were selected and clustered to characterize each of the 5 components. Criteria for each item were established with the requirement that the criteria must be met for all items in a component to receive credit for the component. RESULTS: Results of the survey indicate that 1) approximately half of CSHCN receive care that meets all 5 components established for medical home; 2) most CSHCN have a usual source of care and a personal doctor or nurse, but other components of the medical home, especially elements of care coordination and family-centered care, are lacking; 3) access to a medical home is significantly affected by race/ethnicity, poverty, and the limitations imposed on daily activity by the child's special health care need; and 4) parents of children who do have a medical home report significantly less delayed or forgone care, significantly fewer unmet health care needs, and significantly fewer unmet needs for family support services. The 5 components described represent major characteristics of the comprehensive care model recommended for all children by the AAP. CONCLUSIONS: The findings suggest that although some components of the medical home concept have been achieved for most CSHCN, the comprehensive care model described by the AAP policy statement on the medical home is not yet in place for a significant number of CSHCN and their families.
SN - 0031-4005
AD - Division of Services for Children With Special Health Care Needs, Health Resources and Services Administration, Parklawn Bldg, 18-A-18, 5600 Fishers Ln, Rockville, MD 20857
U2 - PMID: 15121916.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106611800&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106611827
T1 - Implementing community-based systems of services for children and youths with special health care needs: how well are we doing?
AU - McPherson M
AU - Weissman G
AU - Strickland BB
AU - van Dyck PC
AU - Blumberg SJ
AU - Newacheck PW
Y1 - 2004/05/03/2004 May Supplement
N1 - Accession Number: 106611827. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2004 May Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: National Survey of Children With Special Health Care Needs. NLM UID: 0376422.
KW - Child Health Services
KW - Child, Disabled
KW - Community Health Services -- In Infancy and Childhood
KW - Health Services Accessibility -- In Infancy and Childhood
KW - Adolescence
KW - Child
KW - Interviews
KW - Questionnaires
KW - Surveys
KW - Telephone
KW - United States
KW - Human
SP - 1538
EP - 1544
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
IS - 5 Part 2
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To provide a baseline measure of the proportion of US children who meet the Maternal and Child Health Bureau's core outcomes for children with special health care needs (CSHCN). Those core outcomes include the following: 1) families of CSHCN will partner in decision making and will be satisfied with the services that they receive; 2) CSHCN will receive coordinated, ongoing comprehensive care within a medical home; 3) families of CSHCN will have adequate private and/or public insurance to pay for the services that they need; 4) children will be screened early and continuously for special health care needs; 5) community-based service systems will be organized so that families can use them easily; and 6) youths with special health care needs will receive the services necessary to make transitions to adult life, including adult health care, work, and independence. METHODS: A national household survey was conducted using telephone interviews. We analyzed data on 38,866 CSHCN included in the 2001 National Survey of CSHCN and 13,579 children included in the 2001 National Health Interview Survey. We assessed the proportion of US children who met each of the 6 core outcomes for CSHCN using data from 2 surveys. RESULTS: Success rates ranged from 6% (the core outcome on successful transition to adulthood) to 74% (the core outcome on organization of the service system). For 5 of the 6 core outcomes, success rates exceeded 50%. CONCLUSION: Our results indicate that, for the most part, the United States is well positioned to meet the 6 core outcomes. However, much more work lies ahead before success can be claimed. This is especially true for the core outcome on transition to adulthood, for which only 6% of children in the target population are now meeting this goal.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Ln, Rm 18A27, Parklawn Bldg, Rockville, MD 20857; mmcpherson@hrsa.gov
U2 - PMID: 15121923.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sriram, Krishnan
AU - Benkovic, Stanley A.
AU - Hebert, Meleik A.
AU - Miller, Diane B.
AU - O'Calaghan, James P.
T1 - Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/05/07/
VL - 279
IS - 19
M3 - Article
SP - 19936
EP - 19947
SN - 00219258
AB - Reactive gliosis is a hallmark of disease-, trauma-, and chemical-induced damage to the central nervous system. The signaling pathways associated with this response to neural injury remain to be elucidated, but recent evidence implicates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Here, we used the known dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to selectively damage striatal dopaminergic nerve terminals and elicit a glial response. We then analyzed changes in gene expression and protein phosphorylation, in vivo, to identify ligands and mediators of the JAK-STAT pathway that accompany glial activation. Administration of MPTP caused rapid tyrosine (Tyr-705) phosphorylation and nuclear translocation of STAT3 in striatal astrocytes, prior to the induction of glial fibrillary acidic protein mRNA and protein. Pharmacological protection of dopaminergic nerve terminals with nomifensine abolished MPTP-mediated phosphorylation and translocation of STAT3 and prevented induction of astrogliosis. Among the Janus kinase family of tyrosine kinases, only JAK2 was associated with the phosphorylation of STAT3 after MPTP and, inhibition of JAK2 by AG490, in vivo, attenuated both the phosphorylation of STAT3 and induction of GFAP. The p44/42 mitogen-activated protein kinase (MAPK; ERK½) also was activated by MPTP, but was not associated with activation of STAT3, because serine (Ser-727) was not phosphorylated. The mRNA for ligands of the gp130-JAK/STAT3 signaling pathway, interleukin-6, leukemia inhibitory factor, and oncostatin M were elevated prior to activation of STAT3 and induction of astrogliosis; neuroprotection with nomifensine blocked these effects of MPTP. Taken together, our results suggest that the gp130-mediated activation of JAK2/STAT3 signaling pathway may play a key role in the induction of astrogliosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - ASTROCYTES
KW - CELLULAR signal transduction
KW - NEUROGLIA
KW - PHOSPHORYLATION
KW - CENTRAL nervous system
N1 - Accession Number: 13297165; Sriram, Krishnan 1 Benkovic, Stanley A. 1 Hebert, Meleik A. 1 Miller, Diane B. 1 O'Calaghan, James P. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: 5/7/2004, Vol. 279 Issue 19, p19936; Subject Term: CYTOKINES; Subject Term: ASTROCYTES; Subject Term: CELLULAR signal transduction; Subject Term: NEUROGLIA; Subject Term: PHOSPHORYLATION; Subject Term: CENTRAL nervous system; Number of Pages: 12p; Illustrations: 12 Color Photographs, 4 Black and White Photographs, 1 Diagram, 29 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hess, Sonja
AU - Gustafson, Kirk R.
AU - Milanowski, Dennis J.
AU - Alvira, Edgardo
AU - Lipton, Mark A.
AU - Pannell, Lewis K.
T1 - Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography–electrospray ionization mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2004/05/07/
VL - 1035
IS - 2
M3 - Article
SP - 211
SN - 00219673
AB - Unusual amino acids such as β-methoxytyrosine (β-MeOTyr), allo-threonine (allo-Thr) and allo-isoleucine (allo-Ile) were derivatized with N-α-(2,4-dinitro-5-fluorophenyl)-l-alaninamide (FDAA), 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate (GITC), (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester (S-NIFE), or o-phthalaldehyde/isobutyryl-l-cysteine (OPA-IBLC), and then separated via reversed-phase high-performance chromatography followed by UV and electrospray ionization mass spectrometry detection. FDAA generally showed the highest enantioselectivity but the lowest sensitivity among the chiral derivatizing agents (CDAs) investigated. The detection limit of FDAA-derivatized amino acids was in the low picomolar range. Although the enantioselectivity of FDAA derivatives was generally quite high, its selectivity among β-MeOTyr isomers was poor. The best separation of β-MeOTyr stereoisomers was achieved with S-NIFE. Due to the complex relationships between the investigated CDAs, stereochemical analyses using a combination of two or more of the CDAs gave the most reliable results for a given separation problem. In general, the methods described are selective and reliable, and are being applied to the analysis of unusual amino acids as they occur in marine peptides. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Spectrum analysis
KW - Amino acids
KW - Symmetry (Physics)
KW - Chirality
KW - Derivatization, LC
N1 - Accession Number: 12740558; Hess, Sonja 1; Email Address: sonja_hess@nih.gov; Gustafson, Kirk R. 2; Milanowski, Dennis J. 2; Alvira, Edgardo 3; Lipton, Mark A. 3; Pannell, Lewis K. 1; Affiliations: 1: Structural Mass Spectrometry Facility, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Building 8, Room B2A21, Bethesda, MD 20892-0805, USA; 2: Molecular Targets Development Program, CCR, NCI-Frederick, Frederick, MD, USA; 3: Department of Chemistry, Purdue University, West Lafayette, IN, USA; Issue Info: May2004, Vol. 1035 Issue 2, p211; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Spectrum analysis; Subject Term: Amino acids; Subject Term: Symmetry (Physics); Author-Supplied Keyword: Chirality; Author-Supplied Keyword: Derivatization, LC; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2004.02.068
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Song, James X.
AU - Wassell, James T.
AU - Kapadia, Asha
T1 - Relative mortality for correlated lifetime data
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2004/05/10/
VL - 45
IS - 4
M3 - Article
SP - 849
SN - 01679473
AB - Comparing correlated lifetimes for a group of individuals to a standard reference population may require variance adjustment of marginal model estimates or the use of conditional random effects models with shared frailty. We present the cumulative relative mortality, the marginal model robust variance estimator and the frailty models in estimating relative mortality for individuals who have correlated lifetimes due to group clustering. The positive stable and gamma frailty distributions are considered in the frailty models. The performances of both marginal and frailty models are compared using simulation. Applying these methods, we show siblings for centenarians had longer life spans than their US cohort reference population. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - ESTIMATES
KW - SIMULATION methods & models
KW - ANALYSIS of variance
KW - Correlated survival data
KW - Cumulative relative mortality
KW - Frailty model
KW - Marginal survival model
KW - Robust variance estimator
KW - Taylor linearization
N1 - Accession Number: 12642219; Song, James X. 1; Email Address: james.song.b@bayer.com Wassell, James T. 2 Kapadia, Asha 3; Affiliation: 1: Department of Biometry, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA 2: Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale, Morgantown, WV 26505, USA 3: UT-Houston School of Public Health, 1200 Herman Pressler, Houston, TX 77030, USA; Source Info: May2004, Vol. 45 Issue 4, p849; Subject Term: ESTIMATION theory; Subject Term: ESTIMATES; Subject Term: SIMULATION methods & models; Subject Term: ANALYSIS of variance; Author-Supplied Keyword: Correlated survival data; Author-Supplied Keyword: Cumulative relative mortality; Author-Supplied Keyword: Frailty model; Author-Supplied Keyword: Marginal survival model; Author-Supplied Keyword: Robust variance estimator; Author-Supplied Keyword: Taylor linearization; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/S0167-9473(03)00096-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12642219&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Lin, Jordan
T1 - Call efforts and subject matter estimates: the experience with a nutrition related RDD survey.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2004/05/13/2004 Annual Meeting, Phoenix, AZ
M3 - Conference Paper
SP - N.PAG
AB - Using the example of a national RDD survey about health and diet knowledge, attitude, and practice, this study explores the relationships between call efforts, such as refusal conversion and number of calls, and subject matter estimates. Three distinguishing features of the study are: (1) it examines responses to health and diet topics, including knowledge, attitude, and practice; (2) it investigates responses collected and/or coded using dichotomous measures (e.g., yes, no) and rank-order measures (e.g., degree of agreement); and (3) it isolates the relationships between call efforts and response variations by controlling for not only demographic factors but also other substantive covariates. Preliminary results suggest subject matter estimates are fairly robust with respect to levels and measures of call effort, content of subject matter, and types of response measure. In cases where estimate variations are found to be related to call efforts, there does not appear to be a discernible pattern. These findings should enrich survey researchers? understanding of the impacts of extra call efforts on RDD survey results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TELEPHONE surveys -- Random digit dialing
KW - SAMPLING (Statistics)
KW - ATTITUDES toward health
KW - DIET
KW - TELEPHONE calls
KW - ORAL communication
KW - non
KW - rdd
KW - response
N1 - Accession Number: 16022591; Lin, Jordan 1; Email Address: clin@cfsan.fda.gov; Affiliation: 1: US Food and Drug Administration; Source Info: 2004 Annual Meeting, Phoenix, AZ, pN.PAG; Subject Term: TELEPHONE surveys -- Random digit dialing; Subject Term: SAMPLING (Statistics); Subject Term: ATTITUDES toward health; Subject Term: DIET; Subject Term: TELEPHONE calls; Subject Term: ORAL communication; Author-Supplied Keyword: non; Author-Supplied Keyword: rdd; Author-Supplied Keyword: response; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 0p; Document Type: Conference Paper
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Murphy, Joe
AU - Baxter, Rodney
AU - Eyerman, Joe
AU - Cunningham, David
AU - Barker, Peggy
T1 - A System for Detecting Interviewer Falsification.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2004/05/13/2004 Annual Meeting, Phoenix, AZ
M3 - Conference Paper
SP - N.PAG
AB - The National Survey on Drug Use and Health (NSDUH), a federally sponsored annual survey that gathers data on substance use and abuse among the non-institutionalized household population of the United States, has developed a detailed system for the detection of interviewer falsification. This process includes phone, mail, and in-person field verification procedures, and the review of interview and interviewer-level process data to identify cases and interviewers requiring extra verification efforts. While these components of the system successfully identify a majority of potential falsifiers, more savvy falsifiers may be able to remain undetected if they are aware that their process data are being scrutinized. To address this gap, the NSDUH has recently added a new component to the falsification detection system: the regular review of interview response and question-level timing data. Based on what is known about the area in which an interviewer is working and the types of cases he or she is assigned, a likely range of interview responses is calculated. Response distributions are compared to this likely range at the interviewer level to identify interviewers whose responses appear to be highly unlikely, given their caseloads. These additional measures make it even more difficult for falsifiers to remain undetected, since they would need to have a specific understanding of the prevalence and correlates of substance use in order to enter likely responses. Similarly, question-level timings for particular items that require certain interviewer-respondent interactions are compared to a ?gold standard? to detect outliers. Once potential falsifiers are identified, the work of the suspected interviewers is subject to 100 percent and/or in-person verification. This paper will detail the structure and operationalization of this system and will present examples of its effectiveness on NSDUH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURVEYS
KW - FALSIFICATION
KW - SUBSTANCE abuse
KW - HEALTH surveys -- United States
KW - INTERVIEWS
KW - UNITED States
KW - based
KW - Falsification
KW - field
KW - fraud
KW - interviewers
KW - model
KW - prediction
N1 - Accession Number: 16022665; Murphy, Joe 1; Email Address: jmurphy@rti.org Baxter, Rodney 1; Email Address: rbaxter@rti.org Eyerman, Joe 1; Email Address: eyerman@rti.org Cunningham, David 1; Email Address: dbc@rti.org Barker, Peggy 2; Email Address: pbarker@samhsa.gov; Affiliation: 1: RTI International 2: Substance Abuse and Mental Health Services Administration; Source Info: 2004 Annual Meeting, Phoenix, AZ, pN.PAG; Subject Term: SURVEYS; Subject Term: FALSIFICATION; Subject Term: SUBSTANCE abuse; Subject Term: HEALTH surveys -- United States; Subject Term: INTERVIEWS; Subject Term: UNITED States; Author-Supplied Keyword: based; Author-Supplied Keyword: Falsification; Author-Supplied Keyword: field; Author-Supplied Keyword: fraud; Author-Supplied Keyword: interviewers; Author-Supplied Keyword: model; Author-Supplied Keyword: prediction; Number of Pages: 0p; Document Type: Conference Paper
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16022665&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Rodkin, Sergei
AU - Olson, Lorayn
AU - Frankel, Martin
AU - Blumberg, Stephen
AU - O’Connor, Kathleen
AU - Kogan, Michael
T1 - A Promise or a Partial Payment: The Successful Use of Incentives in an RDD Survey.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2004/05/13/2004 Annual Meeting, Phoenix, AZ
M3 - Conference Paper
SP - N.PAG
AB - In an effort to achieve high response rates on a random-digit-dialing telephone survey, incentives were incorporated into a follow-up effort for 10,500 eligible nonrespondents. An experimental design allowed for a comparison of the impact of (1) offering a $15.00 or $25.00 incentive for completion of a 25-minute interview and (2) enclosing an initial $5.00 payment with the nonresponse follow-up letter or just promising to send the full incentive upon completion of the interview. The experiment was conducted as part of the National Survey of Children’s Health, a module of the State and Local Area Integrated Telephone Survey that is being sponsored by the Maternal and Child Health Bureau, Health Resources and Services Administration, and is conducted by the National Center for Health Statistics, Centers for Disease Control and Prevention. A random-digit-dialing sample of households with children less than 18 years of age was selected from each of the 50 states and Washington, DC. Non-responding households that were known to include age-eligible chldren were included in this experiment. Letters were mailed to addresses that had been matched to sampled telephone numbers. If no addresses were available, the full payment ($15.00 or $25.00) for completing the interview was offered when the household was called. Completion rates for the six treatment groups (incentive amount crossed by initial payment, promise of payment, or no letter) will be compared. Preliminary results from the first wave indicate that partial incentive payments accompanying advance letters yield the highest participation rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- American Association for Public Opinion Research is the property of American Association for Public Opinion Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TELEPHONE surveys -- Random digit dialing
KW - HEALTH surveys
KW - CHILDREN
KW - SAMPLING (Statistics)
KW - HOUSEHOLDS
KW - INTERVIEWS
KW - incentives
KW - RDD
KW - survey
KW - telephone
N1 - Accession Number: 16022610; Rodkin, Sergei 1; Email Address: Sergei_Rodkin@abtassoc.com Olson, Lorayn 1; Email Address: elazan@aol.com Frankel, Martin 2; Email Address: martin_frankel@baruch.cuny.edu Blumberg, Stephen 3; Email Address: sblumberg@cdc.gov O’Connor, Kathleen 3; Email Address: koconnor1@cdc.gov Kogan, Michael 4; Email Address: mkogan@hrsa.gov; Affiliation: 1: Abt Associates Inc. 2: Baruch College and Abt Associates Inc. 3: National Center for Health Statistics 4: HRSA / Maternal and Child Health Bureau; Source Info: 2004 Annual Meeting, Phoenix, AZ, pN.PAG; Subject Term: TELEPHONE surveys -- Random digit dialing; Subject Term: HEALTH surveys; Subject Term: CHILDREN; Subject Term: SAMPLING (Statistics); Subject Term: HOUSEHOLDS; Subject Term: INTERVIEWS; Author-Supplied Keyword: incentives; Author-Supplied Keyword: RDD; Author-Supplied Keyword: survey; Author-Supplied Keyword: telephone; NAICS/Industry Codes: 814110 Private Households; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 0p; Document Type: Conference Paper
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cordoba-Rodriguez, Ruth
AU - Fang, Hui
AU - Lankford, Carla S. R.
AU - Frucht, David M.
T1 - Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1β and IL-18.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/05/14/
VL - 279
IS - 20
M3 - Article
SP - 20563
EP - 20566
SN - 00219258
AB - Anthrax lethal toxin (LT), a critical virulence factor for Bacillus anthracis, has been demonstrated to cleave and to inactivate mitogen-activated protein kinase kinases (MAPKKs) that propagate prosurvival signals in macrophages (1–5). Whether this action of anthrax LT leads to the production of proinflammatory cytokines by macrophages has been more controversial (6, 7). We now report that anthrax LT treatment leads to the specific extracellular release of interleukin (IL)-Iβ and IL-18 by the murine macrophage cell lines, RAW264.7 and J774A.1. Studies of the processing of IL-Iβ reveal that the levels of activated/cleaved IL-Iβ in RAW264.7 and J774.A1 cells are increased following treatment with anthrax LT. Enhanced processing of IL-Iβ directly correlates with increased levels in the activation of its upstream regulator, IL-lβ-converting enzyme/Caspase-1 (ICE). The extracellular release of IL-Iβ and IL-18 in response to anthrax LT is ICE-dependent, as an ICE-specific inhibitor blocks this process. These data indicate that ICE, IL-lβ, and IL-18 are downstream effectors of anthrax LT in macrophages, providing the basis for new bioassays for anthrax LT activity and representing potential therapeutic targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTHRAX
KW - TOXINS
KW - BACILLUS anthracis
KW - PROTEIN kinases
KW - MITOGENS
KW - INTERLEUKINS
KW - MACROPHAGES
KW - BIOLOGICAL assay
N1 - Accession Number: 13364120; Cordoba-Rodriguez, Ruth 1 Fang, Hui 1 Lankford, Carla S. R. 1 Frucht, David M. 1; Email Address: frucht@cber.fda.gov; Affiliation: 1: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 5/14/2004, Vol. 279 Issue 20, p20563; Subject Term: ANTHRAX; Subject Term: TOXINS; Subject Term: BACILLUS anthracis; Subject Term: PROTEIN kinases; Subject Term: MITOGENS; Subject Term: INTERLEUKINS; Subject Term: MACROPHAGES; Subject Term: BIOLOGICAL assay; Number of Pages: 4p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1074/jbc.C300539200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13364120&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Budge, Philip J.
AU - Yeqiang Li
AU - Beeler, Judy A.
AU - Graham, Barney S.
T1 - RhoA-Derived Peptide Dimers Share Mechanistic Properties with Other Polyanionic Inhibitors of Respiratory Syncytial Virus (RSV), Including Disruption of Viral Attachment and Dependence on RSV G.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/05/15/
VL - 78
IS - 10
M3 - Article
SP - 5015
EP - 5022
SN - 0022538X
AB - Large polyanionic molecules, such as sulfated polysaccharides (including soluble heparin and dextran sulfate), synthetic polyanionic polymers, and negatively charged proteins, have been shown to broadly inhibit several enveloped viruses. We recently reported the antiviral activity of a peptide derived from amino acids 77 to 95 of a potential binding partner of respiratory syncytial virus F protein (RSV F), the GTPase RhoA. A subsequent study with a truncated peptide (amino acids 80 to 94) revealed that optimal antiviral activity required dimerization via intermolecular disulfide bonds. We report here that the net negative charge of this peptide is also a determining factor for its antiviral activity and that it, like other polyanions, inhibits virus attachment. In a flow cytometry-based binding assay, peptide 80–94, heparin, and dextran sulfate inhibited the attachment of virus to cells at 4°C at the same effective concentrations at which they prevent viral infectivity. Interestingly, time-of-addition experiments revealed that peptide 80–94 and soluble heparin were also able to inhibit the infectivity of a virus that had been prebound to cells at 4°C, as had previously been shown for dextran sulfate, suggesting a potential role for postattachment effects of polyanions on RSV entry. Neutralization experiments with recombinant viruses showed that the antiviral activities of peptide 80–94 and dextran sulfate were diminished in the absence of the RSV attachment glycoprotein (G). Taken together, these data indicate that the antiviral activity of RhoA-derived peptides is functionally similar to that of other polyanions, is dependent on RSV G, and does not specifically relate to a protein-protein interaction between F and RhoA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - PARAMYXOVIRUSES
KW - PEPTIDES
KW - VIRUS inhibitors
KW - PROTEINS
KW - VIRAL genetics
N1 - Accession Number: 13232587; Budge, Philip J. 1,2 Yeqiang Li 3 Beeler, Judy A. 3 Graham, Barney S. 2; Email Address: bgraham@nih.gov; Affiliation: 1: Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 2: viral Pathogenesis Laboratory, Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 3: Laboratory of Pediatric and Respiratory Virus Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: May2004, Vol. 78 Issue 10, p5015; Subject Term: RESPIRATORY syncytial virus; Subject Term: PARAMYXOVIRUSES; Subject Term: PEPTIDES; Subject Term: VIRUS inhibitors; Subject Term: PROTEINS; Subject Term: VIRAL genetics; Number of Pages: 8p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.10.5015-5022.2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13232587&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Azadi, Shahla
AU - Klink, Kimberly J.
AU - Meade, B. Jean
T1 - Divergent immunological responses following glutaraldehyde exposure
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/05/15/
VL - 197
IS - 1
M3 - Article
SP - 1
SN - 0041008X
AB - Although Glutaraldehyde (Glut) has been demonstrated to be a moderate contact sensitizer, numerous cases of occupational asthma related to Glut exposure have been reported. The purpose of these studies was to examine the dose–response relationship between Glut exposure and the development of T cell-mediated vs. IgE- mediated responses. Initial evaluation of the sensitization potential was conducted using the local lymph node assay (LLNA) at concentrations ranging from 0.75% to 2.5%. A concentration-dependent increase in lymphocyte proliferation was observed with EC3 values of 0.072% and 0.089% in CBA and BALB/c mice, respectively. The mouse ear swelling test (MEST) was used to evaluate the potential for Glut to elicit IgE (1/2 h post challenge) and contact hypersensitivity (24 and 48 h post challenge) responses. An immediate response was observed in animals induced and challenged with 2.5% Glut, whereas animals induced with 0.1% or 0.75% and challenged with 2.5% exhibited a delayed response 48 h post challenge. IgE-inducing potential was evaluated by phenotypic analysis of draining lymph node cells and measurement of total serum IgE levels. Only the 2.5% exposed group demonstrated a significant increase (P < 0.01) in the percentage of IgE+B220+ cells and serum IgE. Following 3 days of dermal exposure, a significant increase in IL-4 mRNA in the draining lymph nodes was observed only in the 2.5% exposed group. These results indicate that the development of an immediate vs. a delayed hypersensitivity response following dermal exposure to Glut is at least in part mediated by the exposure concentration. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Allergy
KW - Serum
KW - Messenger RNA
KW - T cells
KW - Dose response
KW - Glutaraldehyde
KW - LLNA
KW - Th1/Th2 response
N1 - Accession Number: 12984694; Azadi, Shahla 1; Email Address: sazadi@cdc.gov; Klink, Kimberly J. 1; Email Address: kklink@cdc.gov; Meade, B. Jean; Email Address: bhm8@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Issue Info: May2004, Vol. 197 Issue 1, p1; Thesaurus Term: Asthma; Thesaurus Term: Allergy; Subject Term: Serum; Subject Term: Messenger RNA; Subject Term: T cells; Author-Supplied Keyword: Dose response; Author-Supplied Keyword: Glutaraldehyde; Author-Supplied Keyword: LLNA; Author-Supplied Keyword: Th1/Th2 response; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.taap.2004.01.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=12984694&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Casciano, Daniel A.
AU - Fuscoe, James C.
T1 - Preface to mutation research special issue on toxicogenomics
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/05/18/
VL - 549
IS - 1/2
M3 - Editorial
SP - 1
SN - 00275107
N1 - Accession Number: 12982887; Casciano, Daniel A.; Email Address: dcasciano@nctr.fda.gov Fuscoe, James C. 1; Email Address: jfuscoe@nctr.fda.gov; Affiliation: 1: National Center for Toxicological Research, HFT-1, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72223, USA; Source Info: May2004, Vol. 549 Issue 1/2, p1; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.mrfmmm.2004.02.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12982887&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Akerman, G.S.
AU - Rosenzweig, B.A.
AU - Domon, O.E.
AU - McGarrity, L.J.
AU - Blankenship, L.R.
AU - Tsai, C.A.
AU - Culp, S.J.
AU - MacGregor, J.T.
AU - Sistare, F.D.
AU - Chen, J.J.
AU - Morris, S.M.
T1 - Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/05/18/
VL - 549
IS - 1/2
M3 - Article
SP - 43
SN - 00275107
AB - Microarray analysis is a powerful tool to identify the biological effects of drugs or chemicals on cellular gene expression. In this study, we compare the relationships between traditional measures of genetic toxicology and mutagen-induced alterations in gene expression profiles. TK6 cells were incubated with 0.01, 0.1, or 1.0 μM ±anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE) for 4 h and then cultured for an additional 20 h. Aliquots of the exposed cells were removed at 4 and 24 h in order to quantify DNA adduct levels by 32P post-labeling and measure cell viability by cloning efficiency and flow cytometry. Gene expression profiles were developed by extracting total RNA from the control and exposed cells at 4 and 24 h, labeling with Cy3 or Cy5 and hybridizing to a human 350 gene array. Mutant frequencies in the Thymidine Kinase and Hypoxanthine Phosphoribosyl Transferase genes were also determined. The 10α-(deoxyguanosin-N2-yl)-7α,8β,9β-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene (dG-N2-BPDE) adduct increased as a function of dose and was the only adduct identified. A dose-related decrease in cell viability was evident at 24 h, but not at 4 h. Cell death occurred by apoptosis. At 4 h, analysis of the gene expression profiles revealed that Glutathione Peroxidase and Gadd45 were consistently upregulated (greater than 1.5-fold and significantly (P<0.001 ) greater than the control in two experiments) in response to 1.0 μM BPDE exposure. Fifteen genes were consistently down-regulated (less than 0.67-fold and significantly (P<0.001 ) lower than the control in two experiments) at 4 h in cultures exposed to 1.0 μM BPDE. Genes with altered expression at 4 h included genes important in the progression of the cell-cycle and those that inhibit apoptosis. At 24 h post-exposure, 16 genes, involved in cell-cycle control, detoxification, and apoptosis were consistently upregulated; 10 genes were repressed in cultures exposed to the high dose of BPDE. Real-time quantitative PCR confirmed the differential expression of selected genes. These data suggest that changes in gene expression will help to identify effects of drugs and chemicals on molecular pathways in cells, and will provide useful information about the molecular responses associated with DNA damage. Of the endpoints evaluated, DNA adduct formation was the most sensitive indicator of DNA damage. DNA adduct formation was clearly evident at low doses, but the number of genes with significantly altered expression (P<0.001 ) was minimal. Alterations in gene expression were more robust at doses associated with cellular toxicity and induction of mutations. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - GENETIC toxicology
KW - CELL death
KW - DNA
KW - ±anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE)
KW - 10α-(deoxyguanosin-N2-yl)-7α,8β,9β-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene (dG-N2-BPDE)
KW - 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMG-CoA Reductase)
KW - analysis of variance (ANOVA)
KW - Annexin-V-FITC/7-Aminoactinomycin D (ANX-V-FITC/7-AAD)
KW - benzo(a)pyrene (B(a)P)
KW - Benzo(a)pyrene diol epoxide
KW - BPDE
KW - cDNA microarray
KW - dimethyl sulfoxide (DMSO)
KW - Gene expression profiles
KW - Glutathione Peroxidase (GPX)
KW - Glutathione Synthetase (GSS)
KW - Hypoxanthine Phosphoribosyl Transferase (HPRT)
KW - hypoxanthine/aminopterin/thymidine (HAT)
KW - hypoxanthine/thymidine (HT)
KW - Inhibitor of Apoptosis-1 (IAP-1)
KW - Multi-drug Resistant Protein-1 (MDR-1)
KW - Ornithine Decarboxylase (ODC)
KW - phosphate-buffered saline (PBS)
KW - real-time quantitative PCR (RTqPCR)
KW - S-Adenosylmethionine Decarboxylase (SAMdC)
KW - Spermine/Spermidine-N′-Acetyltransferase (SSAT)
KW - Src homology 2 protein (SHB)
KW - Thymidine Kinase (TK)
KW - TK6 cells
KW - topoisomerase-II (topo-II)
N1 - Accession Number: 12982890; Akerman, G.S. 1 Rosenzweig, B.A. 2 Domon, O.E. 1 McGarrity, L.J. 1 Blankenship, L.R. 3 Tsai, C.A. 4 Culp, S.J. 5 MacGregor, J.T. 6 Sistare, F.D. 2 Chen, J.J. 4 Morris, S.M. 1; Email Address: smorris@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, 3801 Muirkirk Road, Laurel, MD, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 4: Division of Biometry and Risk Assessment, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 5: Environmental Health and Program Assurance Staff, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 6: Washington Operations Office, National Center for Toxicological Research, US Food and Drug Administration, Parklawn Building, 5600 Fisher’s Lane, Rockville, MD, USA; Source Info: May2004, Vol. 549 Issue 1/2, p43; Subject Term: GENE expression; Subject Term: GENETIC toxicology; Subject Term: CELL death; Subject Term: DNA; Author-Supplied Keyword: ±anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE); Author-Supplied Keyword: 10α-(deoxyguanosin-N2-yl)-7α,8β,9β-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene (dG-N2-BPDE); Author-Supplied Keyword: 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMG-CoA Reductase); Author-Supplied Keyword: analysis of variance (ANOVA); Author-Supplied Keyword: Annexin-V-FITC/7-Aminoactinomycin D (ANX-V-FITC/7-AAD); Author-Supplied Keyword: benzo(a)pyrene (B(a)P); Author-Supplied Keyword: Benzo(a)pyrene diol epoxide; Author-Supplied Keyword: BPDE; Author-Supplied Keyword: cDNA microarray; Author-Supplied Keyword: dimethyl sulfoxide (DMSO); Author-Supplied Keyword: Gene expression profiles; Author-Supplied Keyword: Glutathione Peroxidase (GPX); Author-Supplied Keyword: Glutathione Synthetase (GSS); Author-Supplied Keyword: Hypoxanthine Phosphoribosyl Transferase (HPRT); Author-Supplied Keyword: hypoxanthine/aminopterin/thymidine (HAT); Author-Supplied Keyword: hypoxanthine/thymidine (HT); Author-Supplied Keyword: Inhibitor of Apoptosis-1 (IAP-1); Author-Supplied Keyword: Multi-drug Resistant Protein-1 (MDR-1); Author-Supplied Keyword: Ornithine Decarboxylase (ODC); Author-Supplied Keyword: phosphate-buffered saline (PBS); Author-Supplied Keyword: real-time quantitative PCR (RTqPCR); Author-Supplied Keyword: S-Adenosylmethionine Decarboxylase (SAMdC); Author-Supplied Keyword: Spermine/Spermidine-N′-Acetyltransferase (SSAT); Author-Supplied Keyword: Src homology 2 protein (SHB); Author-Supplied Keyword: Thymidine Kinase (TK); Author-Supplied Keyword: TK6 cells; Author-Supplied Keyword: topoisomerase-II (topo-II); Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.11.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12982890&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, Angela J.
AU - Dial, Stacey L.
AU - Casciano, Daniel A.
T1 - Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/05/18/
VL - 549
IS - 1/2
M3 - Article
SP - 79
SN - 00275107
AB - Toxicogenomics is a relatively new discipline of toxicology. Microarrays and bioinformatics tools are being used successfully to understand the effects of toxicants on in vivo and in vitro model systems, and to gain a better understanding of the relevance of in vitro models commonly used in toxicological studies. In this study, cDNA filter arrays were used to determine the basal expression patterns of human cultured primary hepatocytes from different male donors; compare the gene expression profile of HepG2 to that of primary hepatocytes; and analyze the effects of three genotoxic hepatocarcinogens; aflatoxin B1 (AFB1), 2-acetylaminofluorene (2AAF), and dimethylnitrosamine (DMN), as well as one non-gentoxic hepatotoxin, acetaminophen (APAP) on gene expression in both in vitro systems. Real-time PCR was used to verify differential gene expression for selected genes. Of the approximately 31,000 genes screened, 3–6% were expressed in primary hepatocytes cultured on matrigel for 16 h. Of these genes, 867 were expressed in cultured hepatocytes from all donors. HepG2 cells expressed about 98% of the genes detectable in cultured primary hepatocytes, however, 31% of the HepG2 transcriptome was unique to the cell line. A number of these genes are expressed in human liver but expression is apparently lost during culture. There was considerable variability in the response to chemical carcinogen exposure in primary hepatocytes from different donors. The transcription factors, E2F1 and ID1 mRNA were increased three-fold and six-fold (P<0.05 , P<0.01 ), respectively, in AFB1 treated primary human hepatocytes but were not altered in HepG2. ID1 expression was also increased by dimethylnitrosamine, acetylaminofluorene and acetaminophen in both primary hepatocytes and HepG2. Identification of genes that are expressed in primary hepatocytes from most donors, as well as those genes with variable expression, will aid in understanding the variability in human reactions to drugs and chemicals. This study suggests that identification of biomarkers of exposure to some chemicals may be possible in the human through microarray analysis, despite the variability in responses. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - TOXICOLOGY
KW - ANTISENSE DNA
KW - LIVER cells
KW - Filter array
KW - Gene expression
KW - HepG2
KW - Primary human hepatocytes
N1 - Accession Number: 12982892; Harris, Angela J. 1; Email Address: aharris@cteh.com Dial, Stacey L. 1 Casciano, Daniel A. 2; Affiliation: 1: Center for Hepatotoxicity, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079, USA 2: Office of the Director, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: May2004, Vol. 549 Issue 1/2, p79; Subject Term: GENE expression; Subject Term: TOXICOLOGY; Subject Term: ANTISENSE DNA; Subject Term: LIVER cells; Author-Supplied Keyword: Filter array; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: HepG2; Author-Supplied Keyword: Primary human hepatocytes; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.11.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12982892&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Moland, Carrie L.
AU - Branham, William S.
AU - Delongchamp, Robert R.
AU - Fang, Hong
AU - Duffy, Peter H.
AU - Peterson, Charlotte A.
AU - Beggs, Marjorie L.
AU - Fuscoe, James C.
T1 - Changes in expression level of genes as a function of time of day in the liver of rats
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2004/05/18/
VL - 549
IS - 1/2
M3 - Article
SP - 115
SN - 00275107
AB - Daily, rhythmic variation in various biochemical, physiological, and behavioral events is a fundamental property of biological organization. Here, we report analysis of relative levels of gene expression in the liver of 16 Fischer 344 rats as a function of time of day. Expression levels were determined for 3906 genes using high-density oligonucleotide microarrays. Of the 3906 genes, 1171 (30%) were clearly expressed while 2735 (70%) were not expressed or the expression was too low to distinguish from background levels. The maximum estimated changes observed for most genes (1029, 88%) were less than 1.5-fold. Analysis of variance and the Kruskal–Wallis tests were used to identify 67 genes whose expression was significantly altered as a function of time of day. These significantly altered genes were classified according to their functions and fall into key cellular pathways including drug metabolism, ion transport, signal transduction, DNA binding and regulation of transcription, and immune response. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLIGONUCLEOTIDES
KW - RATS as laboratory animals
KW - GENES
KW - IMMUNE response
KW - Circadian rhythm
KW - Liver
KW - Microarray analysis
N1 - Accession Number: 12982895; Desai, Varsha G. 1,2; Email Address: vdesai@nctr.fda.gov Moland, Carrie L. 1,2 Branham, William S. 1,2 Delongchamp, Robert R. 3 Fang, Hong 4 Duffy, Peter H. 2 Peterson, Charlotte A. 5 Beggs, Marjorie L. 5 Fuscoe, James C. 1,2; Affiliation: 1: Center for Functional Genomics, National Center for Toxicological Research, US FDA, Jefferson, AR, USA 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, US FDA, Jefferson, AR, USA 4: Northrop Grumman Informational Technology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA 5: Central Arkansas Veterans Health Care System, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Source Info: May2004, Vol. 549 Issue 1/2, p115; Subject Term: OLIGONUCLEOTIDES; Subject Term: RATS as laboratory animals; Subject Term: GENES; Subject Term: IMMUNE response; Author-Supplied Keyword: Circadian rhythm; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Microarray analysis; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2003.11.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12982895&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Mei-ying W.
AU - Bartosch, Birke
AU - Pei Zhang
AU - Guo, Zheng-ping
AU - Renzi, Paula M.
AU - Shen, Li-ming
AU - Granier, Christelle
AU - Feinstone, Stephen M.
AU - Cosset, François-Loïc
AU - Purcell, Robert H.
T1 - Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2004/05/18/
VL - 101
IS - 20
M3 - Article
SP - 7705
EP - 7710
SN - 00278424
AB - The role of humoral immunity in hepatitis C virus (HCV) infections is uncertain. Nevertheless, there is increasing evidence for neutralizing antibodies to HCV in the serum or plasma of chronically infected individuals. Immune globulins prepared by ethanol fractionation of plasma had long been considered safe until a commercial immune globulin product, Gammagard, prepared from plasma from which units containing anti-HCV had been excluded, transmitted HCV to recipients. Studies suggested that the exclusion might have removed neutralizing antibodies from the plasma and hence compromised the safety of the resulting immune globulins. In the present study, by using chimpanzees and a recently validated in vitro system based on neutralization of infectious HCV pseudoparticles, we found broadly reactive neutralizing and protective antibodies in experimental immune globulin preparations made from anti-HCV-positive donations. Neutralizing antibodies were also found in Gammagard lots made from unscreened plasma that did not transmit hepatitis C but not in Gammagard lots, which were prepared from anti-HCV-screened plasma, that did transmit hepatitis C. The results provide an explanation for the mechanism by which the safety of this product was compromised. Immune globulins made from anti-HO/-positive plasma and containing broadly reactive neutralizing antibodies may provide a method of preventing HCV infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - IMMUNOGLOBULINS
KW - GLOBULINS
KW - VIRUS diseases
KW - BLOOD plasma
KW - NEUTRALIZATION (Chemistry)
N1 - Accession Number: 13391837; Yu, Mei-ying W. 1; Email Address: yu@cber.fda.gov Bartosch, Birke 2 Pei Zhang 1 Guo, Zheng-ping 1 Renzi, Paula M. 1 Shen, Li-ming 1 Granier, Christelle 2 Feinstone, Stephen M. 3 Cosset, François-Loïc 2 Purcell, Robert H. 4; Email Address: rpurcell@niaid.nih.gov; Affiliation: 1: Divisions of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892. 2: Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Institut National de Ia Sante et de Ia Recherche Médicale U412, IFR 128, Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 07, France. 3: Divisions of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892. 4: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8009, Bethesda, MD 20892-8009.; Source Info: 5/18/2004, Vol. 101 Issue 20, p7705; Subject Term: HEPATITIS C virus; Subject Term: IMMUNOGLOBULINS; Subject Term: GLOBULINS; Subject Term: VIRUS diseases; Subject Term: BLOOD plasma; Subject Term: NEUTRALIZATION (Chemistry); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0402458101
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DB - aph
ER -
TY - JOUR
AU - Hanigan, M.D.
AU - Crompton, L.A.
AU - Reynolds, C.K.
AU - Wray-Cahen, D.
AU - Lomax, M.A.
AU - France, J.
T1 - An integrative model of amino acid metabolism in the liver of the lactating dairy cow
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
Y1 - 2004/05/21/
VL - 228
IS - 2
M3 - Article
SP - 271
SN - 00225193
AB - The objective of this work was to construct a dynamic model of hepatic amino acid metabolism in the lactating dairy cow that could be parameterized using net flow data from in vivo experiments. The model considers 22 amino acids, ammonia, urea, and 13 energetic metabolites, and was parameterized using a steady-state balance model and two in vivo, net flow experiments conducted with mid-lactation dairy cows. Extracellular flows were derived directly from the observed data. An optimization routine was used to derive nine intracellular flows. The resulting dynamic model was found to be stable across a range of inputs suggesting that it can be perturbed and applied to other physiological states. Although nitrogen was generally in balance, leucine was in slight deficit compared to predicted needs for export protein synthesis, suggesting that an alternative source of leucine (e.g. peptides) was utilized. Simulations of varying glucagon concentrations indicated that an additional 5 mol/d of glucose could be synthesized at the reference substrate concentrations and blood flows. The increased glucose production was supported by increased removal from blood of lactate, glutamate, aspartate, alanine, asparagine, and glutamine. As glucose output increased, ketone body and acetate release increased while CO2 release declined. The pattern of amino acids appearing in hepatic vein blood was affected by changes in amino acid concentration in portal vein blood, portal blood flow rate and glucagon concentration, with methionine and phenylalanine being the most affected of essential amino acids. Experimental evidence is insufficient to determine whether essential amino acids are affected by varying gluconeogenic demands. [Copyright &y& Elsevier]
AB - Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - ORGANIC acids
KW - BLOOD
KW - METABOLISM
KW - Amino acid
KW - Dairy cow
KW - Lactation
KW - Liver
KW - Metabolism
KW - Model
N1 - Accession Number: 12840278; Hanigan, M.D. 1 Crompton, L.A. 2 Reynolds, C.K. 3 Wray-Cahen, D. 4 Lomax, M.A. 5 France, J. 6; Email Address: jfrance@uoguelph.ca; Affiliation: 1: Purina Mills LLC, P.O. Box 66812, St. Louis, MO 63166-6812, USA 2: School of Agriculture, Policy & Development, The University of Reading, Whiteknights, P.O. Box 237, Reading, Berkshire RG6 6AR, UK 3: Department of Animal Sciences, Ohio State University, OARDC, 1680 Madison Avenue, Wooster, OH 44691-4076, USA 4: Center for Devices and Radiological Health, Food and Drug Administration, OST DLS/HSB, 8401 Muirkirk Road, Laurel, MD 20708, USA 5: Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK 6: Department of Animal & Poultry Science, University of Guelph, 50 Gordon Street, Guelph, Ont., Canada N1G 2W1; Source Info: May2004, Vol. 228 Issue 2, p271; Subject Term: AMINO acids; Subject Term: ORGANIC acids; Subject Term: BLOOD; Subject Term: METABOLISM; Author-Supplied Keyword: Amino acid; Author-Supplied Keyword: Dairy cow; Author-Supplied Keyword: Lactation; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Model; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.jtbi.2004.01.010
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DB - aph
ER -
TY - JOUR
AU - Bernier, Roger
AU - Midthun, Karen
T1 - Getting the Science Right and Doing the Right Science in Vaccine Safety.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/06//
VL - 94
IS - 6
M3 - Article
SP - 914
EP - 917
PB - American Public Health Association
SN - 00900036
AB - Because of the potential for conflicts of interest, Salmon et al. propose in this issue the creation of an independent vaccine safety board to assume responsibility for assessing the safety of licensed vaccines. We believe that the current system at the Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC) facilitates needed interactions between those involved in risk assessment and risk management, provides substantial safeguards against conflicts of interest, and results in sound decisions. The CDC, given its role in promoting immunization, may be perceived to have a greater potential conflict and plans to review its vaccine safety activities. Both agencies recognize the importance of transparency in considering vaccine safety and welcome the opportunity to work with the public and the medical community to improve the quality of scientific information and decisionmaking. (Am J Public Health. 2004;94:914-917). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - SAFETY
KW - CONFLICT of interests
KW - HEALTH risk assessment
KW - DECISION making
N1 - Accession Number: 13270359; Bernier, Roger 1; Email Address: rbernier@cdc.gov Midthun, Karen 2; Affiliation: 1: National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Washington, D.C.; Source Info: Jun2004, Vol. 94 Issue 6, p914; Subject Term: VACCINES; Subject Term: SAFETY; Subject Term: CONFLICT of interests; Subject Term: HEALTH risk assessment; Subject Term: DECISION making; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 3234
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bialek, Stephanie R.
AU - Thoroughman, Douglas A.
AU - Hu, Diana
AU - Simard, Edgar P.
AU - Chattin, Jody
AU - Cheek, Jim
AU - Bell, Beth P.
T1 - Hepatitis A Incidence and Hepatitis A Vaccination Among American Indians and Alaska Natives, 1990-2001.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/06//
VL - 94
IS - 6
M3 - Article
SP - 996
EP - 1001
PB - American Public Health Association
SN - 00900036
AB - Objectives. We assessed the effect on trends in hepatitis A incidence of the 1996 recommendation for routine hepatitis A vaccination of American Indian/ Alaska Native (ALAN) children. Methods. We examined trends in hepatitis A incidence among AIAN peoples during 1990-2001 and vaccination coverage levels among children on the largest American Indian reservation. Results. Hepatitis A rates among AIANs declined 20-fold during 1997-2001. Declines in hepatitis A incidence occurred among AIANs in reservation and metropolitan areas. Among 1956 children living on the Navajo Nation whose medical records were reviewed, 1508 (77.1%) had received at least one dose of hepatitis A vaccine, and 1020 (52.1%) had completed the vaccine series. Conclusions. Hepatitis A rates among AIAN peoples have declined dramatically coincident with implementation of routine hepatitis A vaccination of AIAN children. (Am J Public Health. 2004;94:996-1001). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A -- Vaccination
KW - VACCINATION of children
KW - JUVENILE diseases
KW - CHILD health services
KW - UNITED States
N1 - Accession Number: 13270520; Bialek, Stephanie R. 1 Thoroughman, Douglas A. Hu, Diana 2 Simard, Edgar P. 1 Chattin, Jody Cheek, Jim 3 Bell, Beth P. 1; Affiliation: 1: Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Indian Health Service, Tuba City Indian Medical Center, Tuba City, Az. 3: Indian Health Service National Epidemiology Program, Albuquerque, NM.; Source Info: Jun2004, Vol. 94 Issue 6, p996; Subject Term: HEPATITIS A -- Vaccination; Subject Term: VACCINATION of children; Subject Term: JUVENILE diseases; Subject Term: CHILD health services; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 4 Graphs; Document Type: Article; Full Text Word Count: 4193
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steenland, Kyle
AU - Hu, Sherry
AU - Walker, James
T1 - All-Cause and Cause-Specific Mortality by Socioeconomic Status Among Employed Persons in 27 States, 1984--1997.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/06//
VL - 94
IS - 6
M3 - Article
SP - 1037
EP - 1042
PB - American Public Health Association
SN - 00900036
AB - Objectives. We investigated mortality differences according to socioeconomic status (SES)for employed persons in 27 states during 1984-1997. Methods. SES was determined for persons aged 35-64 years according to the "usual occupation" listed on their death certificates. We used US Census denominator data. Results. For all-cause mortality, rate ratios from lowest to highest SES quartile for men and women were 2.02, 1.69, 1.25, and 1.00 and 1.29, 1.01, 1.07, and 1.00, respectively. Percentage of all deaths attributable to being in the lowest 3 SES quartiles was 27%. Inverse SES gradients were strong for most major causes of death except breast cancer and colorectal cancer. Heart disease mortality for highest and lowest SES quartiles dropped 45% and 25%, respectively, between 1984 and 1997. Conclusions. Mortality differences by SES were sustained through the 1990s and are increasing for men. (Am J Public Health. 2004;94:1037-1042). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORTALITY
KW - EMPLOYEES
KW - SOCIAL status
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 13270539; Steenland, Kyle 1; Email Address: nsteenl@sph.emory.edu Hu, Sherry 2 Walker, James 3; Affiliation: 1: Department of Environmental and Occupational Health, Emory School of Public Health, Emory University, Atlanta, Ga. 2: National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta. 3: National Institute for Occupational Safety and Health, CDC Cincinnati, Ohio.; Source Info: Jun2004, Vol. 94 Issue 6, p1037; Subject Term: MORTALITY; Subject Term: EMPLOYEES; Subject Term: SOCIAL status; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5492
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106562954
T1 - Vaccine risk perception among reporters of autism after vaccination: vaccine adverse event reporting system 1990-2001.
AU - Woo EJ
AU - Ball R
AU - Bostrom A
AU - Shadomy SV
AU - Ball LK
AU - Evans G
AU - Braun M
Y1 - 2004/06//
N1 - Accession Number: 106562954. Language: English. Entry Date: 20050121. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Adverse Health Care Event
KW - Attitude to Illness
KW - Autistic Disorder -- Etiology
KW - Autistic Disorder -- Risk Factors
KW - Health Beliefs
KW - Parental Attitudes
KW - Vaccines -- Adverse Effects
KW - Adult
KW - Coding
KW - Communications Media
KW - Data Analysis Software
KW - Descriptive Research
KW - Descriptive Statistics
KW - Disease Surveillance -- Methods
KW - Female
KW - Measles-Mumps-Rubella Vaccine -- Adverse Effects
KW - Mothers -- Psychosocial Factors
KW - Prospective Studies
KW - Record Review
KW - Reports
KW - Structured Interview
KW - Structured Interview Guides
KW - Time Factors
KW - Trust
KW - Voluntary Reporting
KW - Human
SP - 990
EP - 995
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 94
IS - 6
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We investigated vaccine risk perception among reporters of autism to the Vaccine Adverse Event Reporting System (VAERS). METHODS: We conducted structured interviews with 124 parents who reported autism and related disorders to VAERS from 1990 to 2001 and compared results with those of a published survey of parents in the general population. RESULTS: Respondents perceived vaccine-preventable diseases as less serious than did other parents. Only 15% of respondents deemed immunization extremely important for children's health; two thirds had withheld vaccines from their children. CONCLUSIONS: Views of parents who believe vaccines injured their children differ significantly from those of the general population regarding the benefits of immunization. Understanding the factors that shape this perspective can improve communication among vaccine providers, policymakers, and parents/patients.
SN - 0090-0036
AD - Vaccine Safety Branch, Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852; wooj@cber.fda.gov
U2 - PMID: 15249304.
DO - 10.2105/AJPH.94.6.990
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DB - rzh
ER -
TY - JOUR
AU - Biagini, R. E.
AU - Smith, J. P.
AU - Sammons, D. L.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Robertson, S. K.
AU - Snawder, J. E.
T1 - Development of a sensitivity enhanced multiplexed fluorescence covalent microbead immunosorbent assay (FCMIA) for the measurement of glyphosate, atrazine and metolachlor mercapturate in water and urine.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2004/06//
VL - 379
IS - 3
M3 - Article
SP - 368
EP - 374
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Body burdens from exposures to pesticides may be estimated from urinary analyses of pesticide parent/metaboliteauthor="Administrator" time="20040416T135220+0000" data="s" concentrations. Pesticide applicators and others are often exposed to numerous unrelated pesticides, either sequentially or simultaneously. Classically, body burdens of pesticides are analyzed using chemical/instrumental analysis (CIM) or enzyme immunoassays (EIAs). Both of these technologies can usually be used to quantitate one analyte (or closely related groups of analytes) per analysis. Alternatively, multiple analytes can be measured simultaneously using a multiplexed fluorescence covalent microbead immunoassay (FCMIA). We developed a multiplexed FCMIA to simultaneously measure glyphosate (Gly), atrazine (Atz), and metolachlor mercapturate (MM) in water and urine. The assay had least detectable doses (LDDs) in water/diluted urine of 0.11/0.09 ng/ml (Gly, water/urine LDD), 0.10/0.07 ng/ml (Atz)author="Administrator" time="20040416T135943+0000", and 0.09/0.03 ng/ml (MM). The sensitivity for the measurement of Gly was enhanced by derivatization. All assays gave linear responses from the LDDs for each respective pesticide to 300 ng/ml. There was no cross-reactivity between the three analytes. Using a 96-well microplate and an autosampler, as many as 288 separate analyses can be completed in ~120 min with precision, sensitivityauthor="Administrator" time="20040416T140055+0000", and specificity equivalent to, if not better, than that found when these same analytes are measured by CIM or EIA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATRAZINE
KW - WATER -- Glyphosate content
KW - ENZYME-linked immunosorbent assay
KW - IMMUNOASSAY
KW - PESTICIDES
KW - DERIVATIZATION
KW - Atrazine
KW - Biomonitoring
KW - Glyphosate
KW - Luminex
KW - Metolachlor mercapturate
N1 - Accession Number: 15125106; Biagini, R. E. 1; Email Address: reb4@cdc.gov Smith, J. P. 1 Sammons, D. L. 1 MacKenzie, B. A. 1 Striley, C. A. F. 1 Robertson, S. K. 1 Snawder, J. E. 1; Affiliation: 1: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Columbia Parkway, 4676, 45226, Cincinnati, OH, USA.; Source Info: Jun2004, Vol. 379 Issue 3, p368; Subject Term: ATRAZINE; Subject Term: WATER -- Glyphosate content; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: IMMUNOASSAY; Subject Term: PESTICIDES; Subject Term: DERIVATIZATION; Author-Supplied Keyword: Atrazine; Author-Supplied Keyword: Biomonitoring; Author-Supplied Keyword: Glyphosate; Author-Supplied Keyword: Luminex; Author-Supplied Keyword: Metolachlor mercapturate; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s00216-004-2628-8
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ER -
TY - JOUR
ID - 106610582
T1 - Evaluation of the prevalence of antiwheat-, anti-flour dust, and anti-alpha-amylase specific IgE antibodies in US blood donors.
AU - Biagini RE
AU - MacKenzie BA
AU - Sammons DL
AU - Smith JP
AU - Striley CAF
AU - Robertson SK
AU - Snawder JE
Y1 - 2004/06//2004 Jun
N1 - Accession Number: 106610582. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by the National Institute for Occupational Safety and Health (NIOSH) and the National Institute of Environmental Health Services (NIEHS) (Y02ES10189). NLM UID: 9503580.
KW - Occupational Exposure
KW - Cereals
KW - Blood Donors
KW - Immunoglobulins -- Blood
KW - Allergens -- Immunology
KW - Dust
KW - Amylases -- Immunology
KW - Prevalence
KW - Linear Regression
KW - Data Analysis Software
KW - Kruskal-Wallis Test
KW - Spearman's Rank Correlation Coefficient
KW - Confidence Intervals
KW - Funding Source
KW - Human
SP - 649
EP - 653
JO - Annals of Allergy, Asthma & Immunology
JF - Annals of Allergy, Asthma & Immunology
JA - ANN ALLERGY ASTHMA IMMUNOL
VL - 92
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: Asthma in bakery workers is one of the most frequently occurring forms of occupational asthma in the world. Experience from other countries has shown the prevalence of sensitization (IgE) to bakery-associated allergens (BAAs) (wheat [W], flour dust [FD], alpha-amylase [AA]) in bakery workers to be 5% to 53%, whereas the prevalence in nonoccupationally exposed individuals was estimated to be 1.2% to 6.4%. OBJECTIVE: To estimate the prevalence of BAA sensitization by measuring BAA specific IgE in the residual serum tubes of volunteer blood donors. METHODS: Serum samples from 534 volunteer blood donors were measured for anti-W, anti-FD, and anti-AA specific IgE antibodies (in duplicate) using the AlaSTAT microplate assay. Samples with BAA IgE concentrations of 0.35 kU/L or greater were considered positive. RESULTS: Nineteen of 530 serum samples (3.6%; 95% confidence interval [CI], 3.3%-3.9%) were positive for W (range, 0.38-3.61 kU/L), whereas 31 of 534 (5.8%; 95% CI, 5.3%-6.3%) were positive for FD (range, 0.35-2.34 kU/L) and 5 of 529 (1.0%; 95% CI, 0.9%-1.1%) were positive for AA (range, 0.38-1.59 kU/L). Thirteen serum samples were positive for both W and FD; 1 sample each was positive for W and AA and FD and AA. CONCLUSIONS: The prevalence of IgE sensitization in serum samples from a relatively large unselected population of volunteer blood donors is 1.0% for AA, 3.6% for W, and 5.8% for FD, which agrees well with data from other countries for sensitization prevalence rates for nonoccupationally exposed individuals.
SN - 1081-1206
AD - Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, MS C-26, Robert A. Taft Laboratories, 4676 Columbia Pkwy, Cincinnati, OH 45226; rbiagini@cdc.gov
U2 - PMID: 15239172.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - RICE, FAYE L.
T1 - Respirable Crystalline Silica—Phase 1: Variability in fibrogenic potency and exposure–response relationships for silicosis. Hazard assessment document. EH75/4 Health & Safety Executive 2002. ISBN 0 7176 2374 2. 80 pp. Respirable Crystalline ...
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2004/06//
VL - 48
IS - 4
M3 - Article
SP - 379
EP - 380
SN - 00034878
KW - asbestos
KW - brakes
KW - epidemiology
KW - lung cancer
KW - mesothelioma
KW - meta-analysis
KW - motor vehicle mechanics
N1 - Accession Number: 45211616; RICE, FAYE L. 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA; Issue Info: Jun2004, Vol. 48 Issue 4, p379; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: brakes; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: lung cancer; Author-Supplied Keyword: mesothelioma; Author-Supplied Keyword: meta-analysis; Author-Supplied Keyword: motor vehicle mechanics; Number of Pages: 2p; Document Type: Article
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ER -
TY - JOUR
AU - Ryan, Una
AU - O'Hara, Amamda
AU - Lihua Xiao
T1 - Molecular and Biological Characterization of a Cryptosporidium molnari-Like Isolate from a Guppy (Poecilia reticulata).
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/06//
VL - 70
IS - 6
M3 - Article
SP - 3761
EP - 3765
SN - 00992240
AB - Histological, morphological, genetic, and phylogenetic analyses of a Cryptosporidium molnari-like isolate from a guppy (Poecilia reticulata) identified stages consistent with those of C. molnari and revealed that C. molnari is genetically very distinct from all other species of Cryptosporidium. This study represents the first genetic characterization of C. molnari. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCCIDIA
KW - GUPPIES
KW - CRYPTOSPORIDIUM
KW - GENETICS
KW - MICROBIAL ecology
N1 - Accession Number: 13723497; Ryan, Una 1; Email Address: unaryan@central.murlock.edu.au O'Hara, Amamda 1 Lihua Xiao 2; Affiliation: 1: Division of Health Science, School of Veterinary and Biomedical Sciences, Murlock University, Murlock, Western Australia 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia; Source Info: Jun2004, Vol. 70 Issue 6, p3761; Subject Term: COCCIDIA; Subject Term: GUPPIES; Subject Term: CRYPTOSPORIDIUM; Subject Term: GENETICS; Subject Term: MICROBIAL ecology; Number of Pages: 5p; Illustrations: 4 Black and White Photographs, 3 Diagrams; Document Type: Article
L3 - 10.1128/AEM.70.6.3761-3765.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sulaiman, Irshad M.
AU - Jianlin Jiang
AU - Singh, Ajaib
AU - Lihua Xiao
T1 - Distribution of Giardia duodenalis Genotypes and Subgenotypes in Raw Urban Wastewater in Milwaukee, Wisconsin.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/06//
VL - 70
IS - 6
M3 - Article
SP - 3776
EP - 3780
SN - 00992240
AB - Giardia cysts in 131 raw wastewater samples from Milwaukee, Wis., were genotyped by sequence analysis of the triosephosphate isomerase gene which showed the presence of two distinct genotypes (assemblages A and B) of Giardia duodenalis. Of the 131 samples, 111 belonged to assemblage A, and the remaining samples belonged to assemblage B. A high degree of genetic polymorphism was evident within the assemblage B cluster, with 10 distinct subgenotypes identified, eight of which have not been reported before. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - WASTEWATER treatment
KW - SEWAGE
KW - GIARDIA
KW - MILWAUKEE (Wis.)
KW - WISCONSIN
KW - UNITED States
N1 - Accession Number: 13723501; Sulaiman, Irshad M. 1 Jianlin Jiang 1 Singh, Ajaib 2 Lihua Xiao 1; Email Address: lxiao@cdc.gov; Affiliation: 1: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 2: City of Milwaukee Public Health Laboratories, Milwaukee, Wisconsin; Source Info: Jun2004, Vol. 70 Issue 6, p3776; Subject Term: GENETIC polymorphisms; Subject Term: WASTEWATER treatment; Subject Term: SEWAGE; Subject Term: GIARDIA; Subject Term: MILWAUKEE (Wis.); Subject Term: WISCONSIN; Subject Term: UNITED States; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; Number of Pages: 5p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1128/AEM.70.6.3776-3780.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duk Woong Park
AU - Bohwan Jin
AU - Dongdeuk Jang
AU - Kihwa Yang
AU - Jung-Duck Park
AU - Yong-Soon Lee
AU - Doug-Young Ryu
T1 - Genetic polymorphisms of CYP1A1 in a Korean population.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2004/06//
VL - 78
IS - 6
M3 - Article
SP - 306
EP - 308
SN - 03405761
AB - Genetic polymorphisms in the coding exons of the CYP1A1 gene were analyzed in 100 Koreans. Three types of CYP1A1 polymorphisms, specifically G134A, G184C and A2455G, were identified with allelic frequencies of 18, 3, and 16%, respectively, and no linkage was observed among them. The novel G184C polymorphism identified in this study was associated with the mutation of an alanine residue at position 62 to proline. Other earlier-reported polymorphisms in the coding region of CYP1A1 were not detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AROMATASE
KW - EXONS (Genetics)
KW - CYTOCHROME P-450
KW - POLYMERASE chain reaction
KW - GENETIC polymorphisms
KW - METABOLISM
KW - TOXICOLOGY
KW - CYP1A1
KW - Genetic polymorphism
KW - Human
N1 - Accession Number: 15732018; Duk Woong Park 1 Bohwan Jin 1 Dongdeuk Jang 2 Kihwa Yang 2 Jung-Duck Park 3 Yong-Soon Lee 1 Doug-Young Ryu 1; Email Address: dyryu@snu.ac.kr; Affiliation: 1: College of Veterinary Medicine, Seoul National University, San 56-1, Sinlimdong, Kwanakgu, 151-2013;742, Seoul, Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, 122-704, Seoul, Korea 3: College of Medicine, Chung-Ang University, 156-746, Seoul, Korea; Source Info: Jun2004, Vol. 78 Issue 6, p306; Subject Term: AROMATASE; Subject Term: EXONS (Genetics); Subject Term: CYTOCHROME P-450; Subject Term: POLYMERASE chain reaction; Subject Term: GENETIC polymorphisms; Subject Term: METABOLISM; Subject Term: TOXICOLOGY; Author-Supplied Keyword: CYP1A1; Author-Supplied Keyword: Genetic polymorphism; Author-Supplied Keyword: Human; Number of Pages: 3p; Document Type: Article
L3 - 10.1007/s00204-004-0552-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15732018&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106774284
T1 - Health care advocate. Nurses can play a significant role in reducing tobacco use in the U.S.
AU - Murray E
AU - Wewers ME
Y1 - 2004/06//2004 Jun-Jul
N1 - Accession Number: 106774284. Language: English. Entry Date: 20040910. Revision Date: 20150820. Publication Type: Journal Article; consumer/patient teaching materials; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9708553.
KW - Nursing Role
KW - Patient Education
KW - Smoking Cessation
KW - Female
KW - Pregnancy
KW - Smoking -- Complications -- In Pregnancy
KW - Smoking -- Epidemiology
KW - United States Agency for Healthcare Research and Quality
SP - 200
EP - 206
JO - AWHONN Lifelines
JF - AWHONN Lifelines
JA - AWHONN LIFELINES
VL - 8
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1091-5923
AD - Captain, US Public Health Services, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 15305592.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Akpinar-Elci, Muge
AU - Elci, Omur Cinar
AU - Odabasi, Aygul
T1 - Work-Related Asthma-Like Symptoms Among Florists.
JO - CHEST
JF - CHEST
Y1 - 2004/06//
VL - 125
IS - 6
M3 - Article
SP - 2336
EP - 2339
PB - American College of Chest Physicians
SN - 00123692
AB - Objectives: In this study, we evaluated the prevalence of work-related asthma-like symptoms and possible risk factors among florists in Turkey. Methods: We collected questionnaire data from 128 florists, and investigated occupational history and respiratory, ocular, dermal, and nasal symptoms. We evaluated pulmonary function tests with spirometry and atopy by using the skin-prick test. Possible risk factors were analyzed by age-adjusted, smoking-adjusted, and gender-adjusted logistic regression models comparing symptomatic and asymptomatic individuals. Results: The prevalence of work-related asthma-like symptoms was 14.1% (18 patients). We observed excess risk with a high work intensity (odds ratio [OR], 7.3; 95% confidence interval [CI], 1.1 to 51.8) and long work duration (OR, 5.1; 95% CI, 1.2 to 21.6). Florists with work-related asthma-like symptoms were 5.9 times more likely (95% CI, 1.4 to 24.3) to have a positive skin test response to a flower mix allergen. We also observed an excess risk for work-related asthma-like symptoms among those with allergic rhinitis (OR, 13.2; 95% CI, 3.1 to 56.4) and conjunctivitis (OR, 8.4; 95% CI, 2.4 to 29.2). Conclusion: The most prominent risk factors in florists were work intensity, work duration, and specific atopy. [ABSTRACT FROM AUTHOR]
AB - Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASTHMA
KW - OBSTRUCTIVE lung diseases
KW - HEALTH risk assessment
KW - ASTHMATICS
KW - PULMONARY function tests
KW - PATHOLOGICAL physiology
KW - NONINVASIVE diagnostic tests
KW - asthma
KW - atopy
KW - flower
N1 - Accession Number: 13461512; Akpinar-Elci, Muge 1; Email Address: mra8@cdc.gov Elci, Omur Cinar 1 Odabasi, Aygul 2; Affiliation: 1: Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Morgantown, WV 2: Department of Respiratory Medicine, Izmir Chest Diseases and Surgery Training Hospital, Izmir, Turkey; Source Info: Jun2004, Vol. 125 Issue 6, p2336; Subject Term: ASTHMA; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: HEALTH risk assessment; Subject Term: ASTHMATICS; Subject Term: PULMONARY function tests; Subject Term: PATHOLOGICAL physiology; Subject Term: NONINVASIVE diagnostic tests; Author-Supplied Keyword: asthma; Author-Supplied Keyword: atopy; Author-Supplied Keyword: flower; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106502697
T1 - Work-related asthma-like symptoms among florists.
AU - Akpinar-Elci M
AU - Elci OC
AU - Odabasi A
Y1 - 2004/06//
N1 - Accession Number: 106502697. Language: English. Entry Date: 20050819. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: American Thoracic Society questionnaire [modified]. NLM UID: 0231335.
KW - Asthma -- Etiology
KW - Flowers -- Adverse Effects
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Allergens -- Adverse Effects
KW - Asthma -- Epidemiology
KW - Child
KW - Confidence Intervals
KW - Data Analysis Software
KW - Female
KW - Flowers -- Immunology
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Risk Factors
KW - Odds Ratio
KW - Prevalence
KW - Questionnaires
KW - Risk Assessment
KW - Severity of Illness Indices
KW - Skin Tests
KW - Turkey
KW - Human
SP - 2336
EP - 2339
JO - CHEST
JF - CHEST
JA - CHEST
VL - 125
IS - 6
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - OBJECTIVES: In this study, we evaluated the prevalence of work-related asthma-like symptoms and possible risk factors among florists in Turkey. METHODS: We collected questionnaire data from 128 florists, and investigated occupational history and respiratory, ocular, dermal, and nasal symptoms. We evaluated pulmonary function tests with spirometry and atopy by using the skin-prick test. Possible risk factors were analyzed by age-adjusted, smoking-adjusted, and gender-adjusted logistic regression models comparing symptomatic and asymptomatic individuals. RESULTS: The prevalence of work-related asthma-like symptoms was 14.1% (18 patients). We observed excess risk with a high work intensity (odds ratio [OR], 7.3; 95% confidence interval [CI], 1.1 to 51.8) and long work duration (OR, 5.1; 95% CI, 1.2 to 21.6). Florists with work-related asthma-like symptoms were 5.9 times more likely (95% CI, 1.4 to 24.3) to have a positive skin test response to a flower mix allergen. We also observed an excess risk for work-related asthma-like symptoms among those with allergic rhinitis (OR, 13.2; 95% CI, 3.1 to 56.4) and conjunctivitis (OR, 8.4; 95% CI, 2.4 to 29.2). CONCLUSION: The most prominent risk factors in florists were work intensity, work duration, and specific atopy.
SN - 0012-3692
AD - Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Morgantown, WV; mra8@cdc.gov
U2 - PMID: 15189959.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106502697&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bernstein, Wendy B.
AU - Cox, Josephine H.
AU - Aronson, Naomi E.
AU - Tracy, LaRee
AU - Schlienger, Katia
AU - Ratto-Kim, Silvia
AU - Garner, Robin
AU - Cotte, Julio
AU - Zheng, Zhaohui
AU - Winestone, Lena
AU - Liebig, Caroline
AU - Galley, Lynee M.
AU - Connors, Mark
AU - Birx, Deborah L.
AU - Carroll, Richard G.
AU - Levine, Bruce L.
T1 - Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4+ T cells to HIV-infected persons
JO - Clinical Immunology
JF - Clinical Immunology
Y1 - 2004/06//
VL - 111
IS - 3
M3 - Article
SP - 262
EP - 274
SN - 15216616
AB - We have previously shown that adoptive transfer of in vitro CD3/CD28 activated autologous CD4+ T cells results in increased CD4 counts and CD4/CD8 ratios in HIV+ subjects. In this report, analysis of variable beta (Vβ) chain T cell receptor (TCR) repertoire showed that CD3/CD28 stimulation was able to increase polyclonality within skewed spectra types in vitro. In vivo, two of eight subjects showed increase in TCR diversity and importantly, in no subject did a highly skewed in vivo repertoire emerge. Measurement of proliferative response to alloantigen showed increases following infusions. Response to pharmacological stimulus and lectin via Interferon-γ ELISpot assay showed increases in a subset of subjects following infusions. However, interferon-γ response to HIV antigens and peptides declined concurrent with stable or diminishing latent infectious viral load in CD4+ T cells. These data provide further evidence that adoptive transfer of activated autologous CD4+ T cells can augment the immune system. [Copyright &y& Elsevier]
AB - Copyright of Clinical Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cell receptors
KW - LYMPHOCYTES
KW - ANTIGENS
KW - IMMUNITY
KW - Adoptive transfer
KW - CD28
KW - ELISpot
KW - HIV
KW - Immune reconstitution
KW - Immunotherapy
KW - TCR V beta
N1 - Accession Number: 13289004; Bernstein, Wendy B. 1,2,3 Cox, Josephine H. 4 Aronson, Naomi E. 2,5 Tracy, LaRee 6 Schlienger, Katia 7 Ratto-Kim, Silvia 4 Garner, Robin 4 Cotte, Julio 7 Zheng, Zhaohui 7 Winestone, Lena 7 Liebig, Caroline 4 Galley, Lynee M. 4 Connors, Mark 8 Birx, Deborah L. 1 Carroll, Richard G. 7 Levine, Bruce L. 7; Email Address: levinebl@mail.med.upenn.edu; Affiliation: 1: Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD 20850, USA 2: Uniformed Services, University of the Health Sciences, Bethesda, MD 20814, USA 3: National Naval Medical Center, Bethesda, MD 20889, USA 4: Henry M. Jackson Foundation, Rockville MD 20850, USA 5: Walter Reed Army Medical Center, Washington, DC 20307, USA 6: FDA Center for Drug Evaluation and Research, Bethesda, MD 20857, USA 7: Abramson Family Cancer Research Institute at the University of Pennsylvania Cancer Center, Philadelphia, PA 19104-6160, USA 8: National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA; Source Info: Jun2004, Vol. 111 Issue 3, p262; Subject Term: T cell receptors; Subject Term: LYMPHOCYTES; Subject Term: ANTIGENS; Subject Term: IMMUNITY; Author-Supplied Keyword: Adoptive transfer; Author-Supplied Keyword: CD28; Author-Supplied Keyword: ELISpot; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Immune reconstitution; Author-Supplied Keyword: Immunotherapy; Author-Supplied Keyword: TCR V beta; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.clim.2004.03.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106584000
T1 - Osteoporosis prevention: what kind of exercise is best?
AU - Whyte JJ
AU - Marting RN
Y1 - 2004/06//2004 Jun
N1 - Accession Number: 106584000. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials; pictorial; tables/charts; website. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110.
KW - Exercise -- Classification
KW - Osteoporosis -- Prevention and Control
KW - Weight Lifting
KW - Information Resources
KW - World Wide Web
SP - 1002
EP - 1007
JO - Consultant (00107069)
JF - Consultant (00107069)
JA - CONSULTANT
VL - 44
IS - 7
CY - Framingham, Massachusetts
PB - United Business Media
AB - Because of concerns raised by recent studies about the safety of hormone replacement therapy, attention has shifted to alternative therapies for prevention of osteoporosis. Resistance training has been shown to strengthen skeletal muscles, increase bone mineral density (BMD), and reduce fractures. Low-impact aerobic exercises, such as walking, improve cardiovascular fitness but do not create enough stress to increase BMD or muscle mass. A basic resistance training regimen consists of 5 or 6 weight-bearing exercises performed 2 or 3 times a week. Results can be seen in 4 to 6 weeks.
SN - 0010-7069
AD - Medical Advisor, US Department of Health and Human Services (USDHHS), Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wade, Mary Margaret
AU - Volokhov, Dmitriy
AU - Peredelchuk, Mike
AU - Chizhikov, Vladimir
AU - Zhang, Ying
T1 - Accurate mapping of mutations of pyrazinamide-resistant Mycobacterium tuberculosis strains with a scanning-frame oligonucleotide microarray
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2004/06//
VL - 49
IS - 2
M3 - Article
SP - 89
EP - 97
SN - 07328893
AB - The increasing emergence of drug-resistant Mycobacterium tuberculosis poses significant threat to the treatment of tuberculosis. Conventional susceptibility testing for the front-line tuberculosis drug pyrazinamide (PZA) is difficult, because of the requirement for acid pH for the drug to show activity. Resistance to PZA in M. tuberculosis is caused by mutations in the pncA gene, and detection of pncA mutations can be an indicator of PZA resistance. In this study, we examined the feasibility of a microarray-based approach exploiting short overlapping oligonucleotides (sliding-frame array) to rapidly detect pncA mutations (substitutions, deletions, and insertions) in multiple strains of PZA-resistant M. tuberculosis. The genetic mapping of these mutations is necessary to link the gene sequence to the protein function defined by mutant phenotype. Microarray analysis was performed in a blind manner using 57 isolates of M. tuberculosis for which the sequence of the pncA gene was previously determined. Our results showed that all mutations could be unambiguously detected, suggesting that microarray can be a routine and valuable tool for rapid identification of drug-resistant M. tuberculosis isolates. We expect that mutation mapping with a sliding-frame microarray will accelerate the molecular analysis of drug-resistant M. tuberculosis bacteria and the microorganism populations. [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS
KW - MUTATION (Biology)
KW - NUCLEOTIDES
KW - GENE mapping
KW - PHENOTYPE
N1 - Accession Number: 13291443; Wade, Mary Margaret 1 Volokhov, Dmitriy 2 Peredelchuk, Mike 2 Chizhikov, Vladimir 2 Zhang, Ying 1; Email Address: yzhang@jhsph.edu; Affiliation: 1: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD, USA; Source Info: Jun2004, Vol. 49 Issue 2, p89; Subject Term: TUBERCULOSIS; Subject Term: MUTATION (Biology); Subject Term: NUCLEOTIDES; Subject Term: GENE mapping; Subject Term: PHENOTYPE; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2004.01.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rui-Heng Xu
AU - Jian-Feng He
AU - Guo-Wen Peng
AU - De-Wen Yu
AU - Hui-Min Luo
AU - Wei-Sheng Lin
AU - Peng Lin
AU - Ling-Hui Li
AU - Wen-Jia Liang
AU - Jin-Yan Lin
AU - Evans, Meirion R.
AU - Chin-Kei Lee
AU - Schnur, Alan
AU - Field, Hume E.
T1 - Epidemiologic Clues to SARS Origin in China.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/06//
VL - 10
IS - 6
M3 - Article
SP - 1030
EP - 1037
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - An epidemic of severe acute respiratory syndrome (SARS) began in Foshan municipality, Guangdong Province, China, in November 2002. We studied SARS case reports through April 30, 2003, including data from case investigations and a case series analysis of index cases. A total of 1,454 clinically confirmed cases (and 55 deaths) occurred; the epidemic peak was in the first week of February 2003. Healthcare workers accounted for 24% of cases. Clinical signs and symptoms differed between children (<18 years) and older persons (≥65 years). Several observations support the hypothesis of a wild animal origin for SARS. Cases apparently occurred independently in at least five different municipalities; early case-patients were more likely than later patients to report living near a produce market (odds ratio undefined; lower 95% confidence interval 2.39) but not near a farm; and 9 (39%) of 23 early patients, including 6 who lived or worked in Foshan, were food handlers with probable animal contact. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SARS (Disease)
KW - Epidemics
KW - Coronavirus diseases
KW - Respiratory infections
KW - Syndromes
KW - Symptoms
KW - Guangdong Sheng (China)
KW - China
N1 - Accession Number: 13283003; Rui-Heng Xu 1; Jian-Feng He 1; Guo-Wen Peng 1; De-Wen Yu 1; Hui-Min Luo 1; Wei-Sheng Lin 1; Peng Lin 1; Ling-Hui Li 1; Wen-Jia Liang 1; Jin-Yan Lin 1; Evans, Meirion R. 2,3; Email Address: meirion.evans@nphs.wales.nhs.uk; Chin-Kei Lee 4; Schnur, Alan 5; Field, Hume E. 6; Affiliations: 1: Guangdong Province Center for Disease Control and Prevention, Guangzhou, China; 2: University of Wales College of Medicine, Cardiff, United Kingdom; 3: National Public Health Service for Wales, Cardiff, United Kingdom; 4: Australian National University, Canberra, Australia; 5: World Health Organization, Beijing, China; 6: Animal Research Institute, Brisbane, Australia; Issue Info: Jun2004, Vol. 10 Issue 6, p1030; Thesaurus Term: SARS (Disease); Thesaurus Term: Epidemics; Subject Term: Coronavirus diseases; Subject Term: Respiratory infections; Subject Term: Syndromes; Subject Term: Symptoms; Subject: Guangdong Sheng (China); Subject: China; Number of Pages: 8p; Illustrations: 6 Charts, 3 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Hee Park, Seung
AU - Byun, Jung A.
AU - Kim, Hyung Soo
AU - Oh, Hye Young
T1 - Evaluation of lymphocyte subpopulations in draining lymph node cells following allergen and irritant
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2004/06//
VL - 17
IS - 2
M3 - Article
SP - 95
EP - 102
SN - 13826689
AB - The murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for the assessment of the contact sensitization potential. However, there is a need to develop a non-radioisotopic endpoint for the LLNA, because of the radioisotopic method’s requiring the use of special facilities. In this study, we investigated to evaluate the lymphocyte subpopulations in the lymph node cells following allergen and irritant treatment. Female Balb/c mice were treated by the topical application on the dorsum of both ears with sensitizers, 2,4-dinitrochlorobenzene (DNCB), toluene diisocyanate (TDI), and α-hexylcinnamaldehyde (HCA), and an irritant, sodium lauryl sulfate (SLS), once daily for three consecutive days. The lymph node (LN) cells were harvested 72 h after the final treatment. Phenotypic analysis of lymphocytes subsets was performed with a flow cytometry. The allergens DNCB, TDI, and HCA and an irritant, SLS increased cell number compared to the vehicle. Mice were treated with DNCB, HCA, and TDI showed a preferential increase in the percentage of B220+CD40+ cells compared with vehicle and irritant-treated mice. There was an increase in B220+CD86+ cells of mice treated with DNCB, TDI, and HCA, but no significant increases were observed in mice treated with SLS. Mice were treated with DNCB and TDI showed an increase in the percentage of B220+CD23+ cells compared with vehicle and irritant-treated mice. These results suggest that analysis of B cell activation marker, CD40 on B cells may be useful in differentiating allergen and irritant responses in the draining lymph nodes of chemically treated mice. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Lymphocytes
KW - Lymph nodes
KW - Mice as laboratory animals
KW - CD23
KW - CD40
KW - CD86
KW - Flow cytometry
KW - LLNA
N1 - Accession Number: 13397639; Lee, Jong Kwon; Email Address: jkleest@kfda.go.kr; Hee Park, Seung 1; Byun, Jung A. 1; Kim, Hyung Soo 1; Oh, Hye Young 1; Affiliations: 1: Division of Immunotoxicology, National Institute of Toxicology Research, Korea Food and Drug Administration, 122-704 Seoul, South Korea; Issue Info: Jun2004, Vol. 17 Issue 2, p95; Thesaurus Term: Allergens; Subject Term: Lymphocytes; Subject Term: Lymph nodes; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: CD23; Author-Supplied Keyword: CD40; Author-Supplied Keyword: CD86; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: LLNA; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.etap.2004.03.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=13397639&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sprando, Robert L.
AU - Collins, Thomas F.X.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Grundel, Erich
AU - Ruggles, Dennis I.
T1 - Effects of androstenedione on in utero development in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2004/06//
VL - 42
IS - 6
M3 - Article
SP - 917
SN - 02786915
AB - This study was conducted to characterize the effect of androstenedione on estrous cyclicity, mating behavior and fetal development. Thirty-day old rats received corn oil alone or androstenedione (in corn oil) at one of four concentrations (0, 1.0, 5.0, 10.0 or 30.0 mg/kg body weight) by gavage for two weeks prior to mating, during the mating period and throughout gestation. Dose related increases in serum androstenedione, estradiol and estrone were observed in all androstenedione treated animals at gestation day 20. A statistically significant increase in serum testosterone concentration was observed in the 30 mg/kg dose group. Feed and fluid consumption were not affected by androstenedione treatment during the pre-mating or gestational periods, however a statistically significant decrease in the number of females with regular estrous cycles was observed in the 10.0 and 30.0 mg/kg dose groups. Exposure to androstenedione did not affect mean body weight gain during pre-mating or gestation. Slight not statistically significant reductions in the number of implants, number of viable fetuses and number of viable male fetuses were observed in the 30.0 mg/kg androstenedione group. Reductions were not observed in the number of corpora lutea. Fetal growth in terms of fetal weight, crown-rump length, anogenital distance and the number of external abnormalities was not affected by androstenedione exposure. At the doses given, androstenedione had no specific effect on the development of individual bones, including sternebrae. Dose related effects of androstenedione were not observed on the development of soft tissues. A statistically significant increase in moderately enlarged ureter at the kidney was observed in both the 1.0 and 5.0 mg/kg dose groups. Organ weights (expressed per gram of body weight or per gram of brain weight) were not affected by androstenedione treatment. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROSTENEDIONE
KW - ESTRUS
KW - COURTSHIP in animals
KW - FETAL development
KW - ESTRADIOL
KW - ESTRONE
KW - Analysis of Covariance (ANCOVA)
KW - Analysis of Variance (ANOVA)
KW - Androstenedione
KW - Estrous
KW - Fetus
KW - Rats
N1 - Accession Number: 12907687; Sprando, Robert L.; Email Address: rsprando@cfsan.fda.gov Collins, Thomas F.X. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Grundel, Erich 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, USA; Source Info: Jun2004, Vol. 42 Issue 6, p917; Subject Term: ANDROSTENEDIONE; Subject Term: ESTRUS; Subject Term: COURTSHIP in animals; Subject Term: FETAL development; Subject Term: ESTRADIOL; Subject Term: ESTRONE; Author-Supplied Keyword: Analysis of Covariance (ANCOVA); Author-Supplied Keyword: Analysis of Variance (ANOVA); Author-Supplied Keyword: Androstenedione; Author-Supplied Keyword: Estrous; Author-Supplied Keyword: Fetus; Author-Supplied Keyword: Rats; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2004.01.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12907687&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schroeder, Carl M.
AU - White, David G.
AU - Meng, Jianghong
T1 - Retail meat and poultry as a reservoir of antimicrobial-resistant Escherichia coli
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2004/06//
VL - 21
IS - 3
M3 - Article
SP - 249
SN - 07400020
AB - The purpose of this review article is to summarize steadily accruing evidence from around the world which indicate retail meat and poultry are a reservoir of antimicrobial-resistant Escherichia coli. The majority of E. coli recovered from retail meat and poultry have been found resistant to at least one antimicrobial, and an increasing proportion have been found resistant to clinically important, frontline antimicrobials, including trimethoprim-sulphamethoxazole, fluoroquinolones, and third-generation cephalosporins. Continued surveillance throughout the food production continuum is needed to detect emerging resistance phenotypes. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - TRIMETHOPRIM
KW - ANTI-infective agents
KW - CEPHALOSPORINS
KW - Antibiotic resistance
KW - Antimicrobial
KW - Escherichia coli
KW - Poultry
KW - Retail meat
N1 - Accession Number: 12436419; Schroeder, Carl M. 1; Email Address: carl.schroeder@fsis.usda.gov White, David G. 2 Meng, Jianghong 1; Affiliation: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD 20301, USA 2: US Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708, USA; Source Info: Jun2004, Vol. 21 Issue 3, p249; Subject Term: ESCHERICHIA coli; Subject Term: TRIMETHOPRIM; Subject Term: ANTI-infective agents; Subject Term: CEPHALOSPORINS; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: Antimicrobial; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Poultry; Author-Supplied Keyword: Retail meat; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/S0740-0020(03)00074-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Yudong
AU - Fang, Jing
AU - Leonard, Stephen S.
AU - Krishna Rao, K. Murali
T1 - Cadmium inhibits the electron transfer chain and induces Reactive Oxygen Species
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2004/06//
VL - 36
IS - 11
M3 - Article
SP - 1434
EP - 1443
SN - 08915849
AB - Recent research indicates that cadmium (Cd) induces oxidative damage in cells; however, the mechanism of the oxidative stress induced by this metal is unclear. We investigated the effects of Cd on the individual complexes of the electron transfer chain (ETC) and on the stimulation of reactive oxygen species (ROS) production in mitochondria. The activity of complexes II (succinate:ubiquinone oxidoreductase) and III (ubiquinol:cytochrome c oxidoreductase) of mitochondrial ETC from liver, brain, and heart showed greater inhibition by Cd than the other complexes. Cd stimulated ROS production in the mitochondria of all three tissues mentioned above. The effect of various electron donors (NADH, succinate, and 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol) on ROS production was tested separately in the presence and in the absence of Cd. ESR showed that complex III might be the only site of ROS production induced by Cd. The results of kinetic studies and electron turnover experiments suggest that Cd may bind between semiubiquinone and cytochrome b566 of the Q0 site of cytochrome b of complex III, resulting in accumulation of semiubiquinones at the Q0 site. The semiubiquinones, being unstable, are prone to transfer one electron to molecular oxygen to form superoxide, providing a possible mechanism for Cd-induced generation of ROS in mitochondria. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTOSYNTHETIC oxygen evolution
KW - PLANT cell microbodies
KW - CYTOCHROME c
KW - CYTOCHROME oxidase
KW - ADENOSINE triphosphatase
KW - 1,1-diphenyl-2-picrylhydrazyl (DPPH)
KW - 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol (DBH2)
KW - 5,5-dimethyl-L-pyrroline N-oxide (DMPO)
KW - ATP synthase (complex V)
KW - Cadmium
KW - Complex III
KW - cytochrome c oxidase (complex IV)
KW - dichlorophenolindophenol (DCIP)
KW - dodecyl maltoside (DM)
KW - electron spin resonance (ESR)
KW - Electron transfer chain
KW - electron transfer chain (ETC)
KW - Free radicals
KW - Mitochondria
KW - NADH:ubiquinone oxidoreductase (complex I)
KW - phosphate-buffered saline (PBS)
KW - Q cycle
KW - Reactive oxygen species
KW - reactive oxygen species (ROS)
KW - succinate:ubiquinone oxidoreductase (complex II)
KW - ubiquinone:cytochrome c oxidoreductase (complex III)
N1 - Accession Number: 13068574; Wang, Yudong 1,2; Email Address: ybw4@cdc.gov Fang, Jing 3 Leonard, Stephen S. 1 Krishna Rao, K. Murali 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Department of Biochemistry and Molecular Pharmacology, West Virginia University, School of Medicine, Morgantown, WV 26506, USA 3: Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA; Source Info: Jun2004, Vol. 36 Issue 11, p1434; Subject Term: PHOTOSYNTHETIC oxygen evolution; Subject Term: PLANT cell microbodies; Subject Term: CYTOCHROME c; Subject Term: CYTOCHROME oxidase; Subject Term: ADENOSINE triphosphatase; Author-Supplied Keyword: 1,1-diphenyl-2-picrylhydrazyl (DPPH); Author-Supplied Keyword: 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol (DBH2); Author-Supplied Keyword: 5,5-dimethyl-L-pyrroline N-oxide (DMPO); Author-Supplied Keyword: ATP synthase (complex V); Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Complex III; Author-Supplied Keyword: cytochrome c oxidase (complex IV); Author-Supplied Keyword: dichlorophenolindophenol (DCIP); Author-Supplied Keyword: dodecyl maltoside (DM); Author-Supplied Keyword: electron spin resonance (ESR); Author-Supplied Keyword: Electron transfer chain; Author-Supplied Keyword: electron transfer chain (ETC); Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: NADH:ubiquinone oxidoreductase (complex I); Author-Supplied Keyword: phosphate-buffered saline (PBS); Author-Supplied Keyword: Q cycle; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: succinate:ubiquinone oxidoreductase (complex II); Author-Supplied Keyword: ubiquinone:cytochrome c oxidoreductase (complex III); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2004.03.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13068574&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olson, S.H.
AU - Carlson, M.D.A.
AU - Ostrer, H.
AU - Harlap, S.
AU - Stone, A.
AU - Winters, M.
AU - Ambrosone, C.B.
T1 - Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer
JO - Gynecologic Oncology
JF - Gynecologic Oncology
Y1 - 2004/06//
VL - 93
IS - 3
M3 - Article
SP - 615
EP - 620
SN - 00908258
AB - Objective. One way in which parity and use of oral contraceptives may protect against ovarian cancer is by preventing inflammation and oxidative stress associated with ovulation. Since the genes superoxide dismutase (SOD2), myeloperoxidase (MPO), and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress, we investigated whether variants of these genes are associated with risk of ovarian cancer.Methods. In a hospital-based case-control study, we compared 125 cases and 193 controls with respect to prevalence of (1) the T→C (val→ala) substitution at the -9 position in the signal sequence of SOD2; (2) the G→A substitution at the -463 position in the promoter region of MPO; and (3) the C→T (pro→ser) change in exon 6 of NQO1. Genotyping was done using PCR and gel electrophoresis for MPO and NQO1 and using MALDI-TOF mass spectrometry for SOD2.Results. For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1–4.0]. Results for MPO and NQO1 were in the hypothesized directions but were not statistically significant. For MPO, there was a small inverse association among women with GA or AA genotypes (OR = 0.72, 95% CI 0.43–1.2). For NQO1, the TT (ser/ser) genotype was associated with somewhat increased risk (OR = 2.3, 95% CI 0.69–7.6).Conclusions. While these results need to be confirmed in other studies, they point to a possible role for genes involved in oxidative stress in the development of ovarian cancer. [Copyright &y& Elsevier]
AB - Copyright of Gynecologic Oncology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVARIAN cancer
KW - INFLAMMATION
KW - OXIDATIVE stress
KW - OVULATION
KW - Genetic polymorphisms
KW - Manganese superoxide dismutase
KW - Myeloperoxidase
KW - NAD(P)H:oxidoreductase 1
KW - Ovarian carcinoma
N1 - Accession Number: 13396901; Olson, S.H. 1; Email Address: olsons@mskcc.org Carlson, M.D.A. 1 Ostrer, H. 2 Harlap, S. 3 Stone, A. 4 Winters, M. 4 Ambrosone, C.B. 5; Affiliation: 1: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA 2: New York University School of Medicine, New York, NY 10016, USA 3: Mailman School of Public Health, Columbia University, New York, NY 10032, USA 4: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA 5: Roswell Park Cancer Institute, Buffalo, NY 14263, USA; Source Info: Jun2004, Vol. 93 Issue 3, p615; Subject Term: OVARIAN cancer; Subject Term: INFLAMMATION; Subject Term: OXIDATIVE stress; Subject Term: OVULATION; Author-Supplied Keyword: Genetic polymorphisms; Author-Supplied Keyword: Manganese superoxide dismutase; Author-Supplied Keyword: Myeloperoxidase; Author-Supplied Keyword: NAD(P)H:oxidoreductase 1; Author-Supplied Keyword: Ovarian carcinoma; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ygyno.2004.03.027
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - McClellan, Mark B.
T1 - SCHROEDER LECTURE FDA: PROTECTING AND ADVANCING AMERICA'S HEALTH.
JO - Health Matrix: Journal of Law-Medicine
JF - Health Matrix: Journal of Law-Medicine
Y1 - 2004///Summer2004
VL - 14
IS - 2
M3 - Speech
SP - 357
EP - 370
PB - Case Western Reserve University School of Law
SN - 0748383X
AB - Presents a speech by U.S. Food and Drug Administration commissioner Mark B. McClellan, delivered at the Case Western Reserve University's Schroeder Lecture, October 7, 2003. Concern over the increasing medical spending and access to quality care; Factors responsible for the high prices of medicines in the U.S. compared to other countries; Adverse effects of the liability system on medical care.
KW - MEDICAL care costs
KW - MEDICAL care
KW - PUBLIC health
KW - UNITED States
KW - MCCLELLAN, Mark B.
N1 - Accession Number: 14497483; McClellan, Mark B. 1; Affiliation: 1: Commissioner of Food and Drugs, U.S. Department Of Health & Human Services, Food and Drug Administration; Source Info: Summer2004, Vol. 14 Issue 2, p357; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: MCCLELLAN, Mark B.; Number of Pages: 14p; Document Type: Speech
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Basu, Jayasree
AU - Friedman, Bernard
AU - Burstin, Helen
T1 - Managed Care and Preventable Hospitalization among Medicaid Adults.
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/06//
VL - 39
IS - 3
M3 - Article
SP - 489
EP - 510
PB - Wiley-Blackwell
SN - 00179124
AB - The study examines the association between managed care enrollment and preventable hospitalization patterns of adult Medicaid enrollees hospitalized in four states. Hospital discharge data from the Healthcare Cost and Utilization Project (HCUP) database of the Agency for Healthcare Research and Quality (AHRQ) for New York (NY), Pennsylvania (PA), Wisconsin (WI), and Tennessee (TN) residents in the age group 20–64 hospitalized in those states, linked to the Area Resource File (ARF) and American Hospital Association (AHA) survey files for 1997. The study uses separate logistic models for each state comparing preventable admissions with marker admissions (urgent, insensitive to primary care). The model controls for socioeconomic and demographic variables, and severity of illness. Consistently in different states, private health maintenance organization (HMO) enrollment was associated with fewer preventable admissions than marker admissions, compared to private fee-for-service (FFS). However, Medicaid managed care enrollment was not associated with a reduction in preventable admissions, compared to Medicaid FFS. Our analysis suggests that the preventable hospitalization pattern for private HMO enrollees differs significantly from that for commercial FFS enrollees. However, little difference is found between Medicaid HMO enrollees and Medicaid FFS patients. The findings did not vary by the level of Medicaid managed care penetration in the study states. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTPATIENT medical care
KW - MANAGED care plans (Medical care)
KW - MEDICAL care -- Research
KW - MEDICAID
KW - PUBLIC health
KW - PREVENTIVE medicine
KW - MEDICAL care surveys
KW - access
KW - ambulatory care sensitive admissions
KW - hmo enrollment
KW - managed care
KW - medicaid
KW - preventable hospitalization
N1 - Accession Number: 12984751; Basu, Jayasree 1 Friedman, Bernard 2 Burstin, Helen 3; Affiliation: 1: Senior Economist, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD 20850 2: Staff member of the Center for Delivery, Organization and Markets, AHRQ 3: Director of the Center for Primary Care, Prevention, and Clinical Partnerships, AHRQ; Source Info: Jun2004, Vol. 39 Issue 3, p489; Subject Term: OUTPATIENT medical care; Subject Term: MANAGED care plans (Medical care); Subject Term: MEDICAL care -- Research; Subject Term: MEDICAID; Subject Term: PUBLIC health; Subject Term: PREVENTIVE medicine; Subject Term: MEDICAL care surveys; Author-Supplied Keyword: access; Author-Supplied Keyword: ambulatory care sensitive admissions; Author-Supplied Keyword: hmo enrollment; Author-Supplied Keyword: managed care; Author-Supplied Keyword: medicaid; Author-Supplied Keyword: preventable hospitalization; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 22p; Document Type: Article
L3 - 10.1111/j.1475-6773.2004.00241.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106604178
T1 - AHRQ's FY 2005 budget request: new mission, new vision.
AU - Clancy CM
Y1 - 2004/06//
N1 - Accession Number: 106604178. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Health Policy
KW - Organizational Objectives
KW - United States Agency for Healthcare Research and Quality -- Administration
KW - Budgets
KW - Health Resource Allocation
KW - Organizational Policies
KW - Strategic Planning
KW - United States
SP - xi
EP - xviii
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 39
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Director, Agency for Healthcare Research and Quality
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106604205
T1 - Managed care and preventable hospitalization among Medicaid adults.
AU - Basu J
AU - Friedman B
AU - Burstin H
Y1 - 2004/06//
N1 - Accession Number: 106604205. Language: English. Entry Date: 20050408. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Health Maintenance Organizations
KW - Hospitalization
KW - Medicaid
KW - Adult
KW - Comparative Studies
KW - Descriptive Statistics
KW - Fee for Service Plans
KW - Health Resource Utilization
KW - Health Services Misuse
KW - Middle Age
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - Record Review
KW - Retrospective Design
KW - Severity of Illness
KW - United States
KW - Utilization Review
KW - Human
SP - 489
EP - 509
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 39
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVE: The study examines the association between managed care enrollment and preventable hospitalization patterns of adult Medicaid enrollees hospitalized in four states. DATA SOURCES/STUDY SETTING: Hospital discharge data from the Healthcare Cost and Utilization Project (HCUP) database of the Agency for Healthcare Research and Quality (AHRQ) for New York (NY), Pennsylvania (PA), Wisconsin (WI), and Tennessee (TN) residents in the age group 20-64 hospitalized in those states, linked to the Area Resource File (ARF) and American Hospital Association (AHA) survey files for 1997. STUDY DESIGN: The study uses separate logistic models for each state comparing preventable admissions with marker admissions (urgent, insensitive to primary care). The model controls for socioeconomic and demographic variables, and severity of illness. PRINCIPAL FINDINGS: Consistently in different states, private health maintenance organization (HMO) enrollment was associated with fewer preventable admissions than marker admissions, compared to private fee-for-service (FFS). However, Medicaid managed care enrollment was not associated with a reduction in preventable admissions, compared to Medicaid FFS. CONCLUSIONS: Our analysis suggests that the preventable hospitalization pattern for private HMO enrollees differs significantly from that for commercial FFS enrollees. However, little difference is found between Medicaid HMO enrollees and Medicaid FFS patients. The findings did not vary by the level of Medicaid managed care penetration in the study states.
SN - 0017-9124
AD - Senior Economist, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850
U2 - PMID: 15149475.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Klinman, Dennis M.
AU - Currie, Debra
AU - Gursel, Ihsan
AU - Verthelyi, Daniela
T1 - Use of CpG oligodeoxynucleotides as immune adjuvants.
JO - Immunological Reviews
JF - Immunological Reviews
Y1 - 2004/06//
VL - 199
IS - 1
M3 - Article
SP - 201
EP - 216
PB - Wiley-Blackwell
SN - 01052896
AB - Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of T helper 1 (Th1) and pro-inflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5–500-fold. These effects are optimized by maintaining close physical contact between the CpG DNA and the immunogen. Animal challenge models establish that protective immunity can be accelerated and magnified by coadministering CpG DNA with vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans, and in some cases, they increase vaccine-induced immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunological Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDES
KW - IMMUNOLOGICAL adjuvants
KW - B cells
KW - DENDRITIC cells
KW - T cells
N1 - Accession Number: 13017747; Klinman, Dennis M. 1; Email Address: klinman@cber.fda.gov Currie, Debra 1 Gursel, Ihsan 1 Verthelyi, Daniela 2; Affiliation: 1: Section of Retroviral Immunology, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Jun2004, Vol. 199 Issue 1, p201; Subject Term: NUCLEOTIDES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: B cells; Subject Term: DENDRITIC cells; Subject Term: T cells; Number of Pages: 16p; Illustrations: 12 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.0105-2896.2004.00148.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koutchma, Tatiana
AU - Keller, Susanne
AU - Chirtel, Stuart
AU - Parisi, Brian
T1 - Ultraviolet disinfection of juice products in laminar and turbulent flow reactors
JO - Innovative Food Science & Emerging Technologies
JF - Innovative Food Science & Emerging Technologies
Y1 - 2004/06//
VL - 5
IS - 2
M3 - Article
SP - 179
EP - 189
SN - 14668564
AB - Individual physical and chemical factors were examined in a model fluid for their effects on the efficacy of UV light on the destruction of Escherichia coli K-12 bacteria using laminar and turbulent flow treatment systems. Factors unique to juice, such as Brix and pH, did not exhibit a large effect over the range tested when examined individually. The single factor found to consistently affect the efficacy of UV light inactivation in juice was absorbance. Particulate material resulted in apparent increased rates of UV killing when solutions of equal absorption coefficients were compared. The flow rates and mixing in the turbulent flow also affected microbial inactivation: the higher the flow rates the higher inactivation rates in turbulent flow UV reactor. Regression equations were developed to describe the relationship between the rate of reduction of E. coli K-12 and absorption coefficient in a thin film reactor and for turbulent flow UV reactor. Running biodosimetry test with minimum and maximum flow rates is recommended to ascertain safe UV disinfection. [Copyright &y& Elsevier]
AB - Copyright of Innovative Food Science & Emerging Technologies is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VEGETABLE juices
KW - ESCHERICHIA coli
KW - DISINFECTION & disinfectants
KW - FOOD -- Preservation
KW - Absorption coefficient
KW - Apple cider
KW - Escherichia coli
KW - Flow rate
KW - Suspended solids
KW - UV light irradiation
N1 - Accession Number: 13350621; Koutchma, Tatiana 1; Email Address: koutchma@iit.edu Keller, Susanne 2 Chirtel, Stuart 3 Parisi, Brian 1; Affiliation: 1: Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer Road, Summit Agro, IL 60501, USA 2: US Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit Agro, IL 60501, USA 3: US Food and Drug Administration, Center for Food Safety and Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740, USA; Source Info: Jun2004, Vol. 5 Issue 2, p179; Subject Term: VEGETABLE juices; Subject Term: ESCHERICHIA coli; Subject Term: DISINFECTION & disinfectants; Subject Term: FOOD -- Preservation; Author-Supplied Keyword: Absorption coefficient; Author-Supplied Keyword: Apple cider; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Flow rate; Author-Supplied Keyword: Suspended solids; Author-Supplied Keyword: UV light irradiation; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; NAICS/Industry Codes: 311421 Fruit and Vegetable Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ifset.2004.01.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guor-Cheng Fang
AU - Yuh-Shen Wu
AU - Chia-Chium Chu
AU - Peter Pi-Cheng Fu
T1 - Sampling errors in the study of acid gases and anion species in atmospheric aerosols.
JO - International Journal of Environment & Pollution
JF - International Journal of Environment & Pollution
Y1 - 2004/06//
VL - 21
IS - 6
M3 - Article
SP - 566
EP - 578
SN - 09574352
AB - Atmospheric acid aerosols were sampled by two annular denuder systems (ADS) and a micro-orifice uniform deposit impactor (MOUDI) at a traffic site in central Taiwan. Theoretical analysis showed that the relative artifact for HNO[sub3] gas sampling was about 0.53 when the initial HNO3 concentration was under 0.2 µg/m³ and should be considered carefully. The concentrations of gaseous acid at the traffic sampling site were higher than those in the other study. The size distributions of acid aerosols were unimodal for C1-, NO2- and NO3-, and bimodal for SO42-. The dominant acid ions in particles less than 18 µm were SO42-, NO3-, NO2- and C1-. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Environment & Pollution is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Acids
KW - Ions
KW - Coal gas
KW - Taiwan
KW - acid aerosols
KW - annular denuder
KW - ions
KW - MOUDI
KW - size distribution
N1 - Accession Number: 14265740; Guor-Cheng Fang 1; Yuh-Shen Wu 1; Chia-Chium Chu 2; Peter Pi-Cheng Fu 3; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan; 2: Dept of Internal Medicine, Chien Yu Regional Teaching Hospital, Lin Yuang, Kaohsiung 832, Taiwan; 3: Division of Biochemical Toxicology National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; Issue Info: 2004, Vol. 21 Issue 6, p566; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Acids; Thesaurus Term: Ions; Thesaurus Term: Coal gas; Subject: Taiwan; Author-Supplied Keyword: acid aerosols; Author-Supplied Keyword: annular denuder; Author-Supplied Keyword: ions; Author-Supplied Keyword: MOUDI; Author-Supplied Keyword: size distribution; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 13p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - De Jesús, Antonio J.
AU - Olsen, Alan R.
AU - Bryce, John R.
AU - Whiting, Richard C.
T1 - Quantitative contamination and transfer of Escherichia coli from foods by houseflies, Musca domestica L. (Diptera: Muscidae)
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2004/06//
VL - 93
IS - 2
M3 - Article
SP - 259
EP - 262
SN - 01681605
AB - The housefly, Musca domestica L. (Diptera: Muscidae), is recognized as an important factor in the dissemination of various infectious diseases such as cholera, shigellosis, and salmonellosis. They can also serve as a cross-contamination vector for other foodborne pathogens. However, the potential for bacterial transfer by houseflies has been demonstrated in a qualitative rather than quantitative manner. In this study, the numbers of bacteria a housefly can carry on its body and transfer to a clean surface after exposure to a sugar–milk aqueous solution, steak, and potato salad contaminated with a fluorescent gene Escherichia coli (8 log10 CFU/ml) were determined. In the first series of experiments to quantify bacterial numbers on the flies, about 40–60 flies were transferred into a sterile cage, exposed to the food for 30 min, the flies immobilized and the attached E. coli on each fly enumerated. Detectable E. coli (>1.7 log10 CFU/fly) were found on 43% (29/67), 53% (23/43), and 62% (32/52) of the flies in the cages with sugar/milk, steak, and potato salad, respectively. For the positive flies, the geometric mean carriage (log10 CFU/fly) was 2.93±1.24 for sugar–milk, 3.77±1.28 for steak, and 2.25±0.64 for the potato salad. In the second series of experiments, the transfer of bacteria by individual flies from contaminated food to the inner surface of a sterile jar per each landing was determined. E. coli transferred from the sugar–milk was 3.5±0.7 log10 CFU/fly-landing, 3.9±0.7 for steak and 2.61±1.16 for the potato salad. From the initial contamination levels of bacteria and the number of transferred bacteria, it can be calculated that flies contaminate clean surfaces with approximately 0.1 mg of food per landing. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Escherichia coli
KW - Communicable diseases
KW - Housefly
KW - Bacterial transfer
KW - Food
KW - Houseflies
N1 - Accession Number: 13066607; De Jesús, Antonio J.; Email Address: adejesus@cfsan.fda.gov; Olsen, Alan R. 1; Bryce, John R. 1; Whiting, Richard C. 1; Affiliations: 1: U.S. Food and Drug Administration/Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Jun2004, Vol. 93 Issue 2, p259; Thesaurus Term: Food contamination; Thesaurus Term: Escherichia coli; Thesaurus Term: Communicable diseases; Subject Term: Housefly; Author-Supplied Keyword: Bacterial transfer; Author-Supplied Keyword: Food; Author-Supplied Keyword: Houseflies; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2003.12.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wong, Herbert S.
AU - McNamara, Peggy
AU - Greenberg, Warren
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville
AD - George Washington U
T1 - Provider Competition and Health Care Quality: Challenges and Opportunities for Research
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2004/06//
VL - 4
IS - 2
SP - 99
EP - 111
SN - 13896563
N1 - Accession Number: 0800889; Keywords: Health Care; Health; Healthcare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200511
N2 - On May 28, 2003, the Agency for Healthcare Research and Quality and the Federal Trade Commission co-sponsored an invitational conference entitled, "Provider Competition and Quality: Latest Findings and Implications for the Next Generation of Research". The main objectives of this conference were to share and discuss the latest findings on provider competition and quality, to identify implications for antitrust policy, and to develop an agenda for further research in this area. While it is impossible to completely capture the rich exchange of ideas and perspectives that transpired at the conference, we highlight several key themes that emerged and present a research agenda to guide future investigations.
KW - Analysis of Health Care Markets I11
L3 - http://link.springer.com/journal/volumesAndIssues/10754
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UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Romano, Patrick S.
AU - Mutter, Ryan
AD - U CA, Davis
AD - U MD, Baltimore County and Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville
T1 - The Evolving Science of Quality Measurement for Hospitals: Implications for Studies of Competition and Consolidation
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2004/06//
VL - 4
IS - 2
SP - 131
EP - 157
SN - 13896563
N1 - Accession Number: 0800891; Keywords: Hospital; Hospitals; Publication Type: Journal Article; Update Code: 200511
N2 - The literature on hospital competition and quality is young; most empirical studies have focused on few conditions and outcomes. Measures of in-hospital mortality and complications are susceptible to bias from unmeasured severity and transfer/discharge practices. Only one research team has evaluated related process and outcome measures, and none has exploited chart-review or patient survey-based data. Prior studies have generated inconsistent findings, suggesting the need for additional research. We describe the strengths and limitations of various approaches to quality measurement, summarize how quality has been operationalized in studies of hospital competition, outline three mechanisms by which competition may affect hospital quality, and propose measures appropriate for testing each mechanism.
KW - Mergers; Acquisitions; Restructuring; Voting; Proxy Contests; Corporate Governance G34
KW - Analysis of Health Care Markets I11
KW - Production, Pricing, and Market Structure; Size Distribution of Firms L11
L3 - http://link.springer.com/journal/volumesAndIssues/10754
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UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Selden, Thomas M.
AU - Bernard, Didem M.
AD - Center for Financing, Access, and Cost Studies, Agency for Healthcare Research and Quality, Rockville
AD - Center for Financing, Access, and Cost Studies, Agency for Healthcare Research and Quality, Rockville
T1 - Tax Incidence and Net Benefits in the Market for Employment-Related Health Insurance: Sensitivity of Estimates to the Incidence of Employer Costs
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2004/06//
VL - 4
IS - 2
SP - 167
EP - 192
SN - 13896563
N1 - Accession Number: 0800893; Keywords: Health Insurance; Health; Incidence; Insurance; Tax Incidence; Tax System; Tax; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200511
N2 - The market for employment-related coverage contains public transfers through the tax system and private transfers across workers with predictably different risks. We examine both transfers across a wide range of employee characteristics, including age, race, ethnicity, family size, poverty level, and health risk. To resolve longstanding questions regarding the incidence of employer contributions, we simulate a range of alternative incidence scenarios in which (i) all employees offered coverage in a firm share equally in the employer's costs, (ii) burdens are narrowly targeted according to employee-specific health risks, and (iii) intermediate cases with burdens targeted by job characteristics, age, sex, race, ethnicity, and family size. Our results provide evidence regarding the distribution of tax subsidies and net benefits under a range of scenarios that we believe bound the true incidence of employer premium contributions.
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Taxation and Subsidies: Incidence H22
KW - Taxation and Subsidies: Externalities; Redistributive Effects; Environmental Taxes and Subsidies H23
KW - Analysis of Health Care Markets I11
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
KW - Personnel Economics: Compensation and Compensation Methods and Their Effects M52
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Margaret L. Heginbothom
AU - J. T. Magee
AU - Joanna L. Bell
AU - F. D. J. Dunstan
AU - A. J. Howard
AU - Sharon L. Hillier
AU - S. R. Palmer
AU - B. W. Mason
T1 - Laboratory testing policies and their effects on routine surveillance of community antimicrobial resistance.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2004/06//
VL - 53
IS - 6
M3 - Article
SP - 1010
EP - 1017
SN - 03057453
N1 - Accession Number: 19810461; Margaret L. Heginbothom 1; J. T. Magee 1; Joanna L. Bell 1; F. D. J. Dunstan 2; A. J. Howard 1; Sharon L. Hillier 2; S. R. Palmer 2; B. W. Mason 1; Affiliations: 1: National Public Health Service for Wales, Abton House, Wedal Road, Cardiff CF14 3QX;; 2: Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff CF14 4XW, UK; Issue Info: June,2004, Vol. 53 Issue 6, p1010; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mei-Shiang Jang
AU - Haixi Miao
AU - Nadia Carlesso
AU - Leslie Shelly
AU - Andrei Zlobin
AU - Nicole Darack
AU - Jian-Zhong Qin
AU - Brian J. Nickoloff
AU - Lucio Miele
T1 - Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways.
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
Y1 - 2004/06//
VL - 199
IS - 3
M3 - Article
SP - 418
EP - 433
SN - 00219541
AB - Notch signaling is a potential therapeutic target for various solid and hematopoietic malignancies. We have recently shown that downregulation of Notch-1 expression has significant anti-neoplastic activity in pre-clinical models. However, the mechanisms through which Notch modulation may affect cell fate in cancer remain poorly understood. We had previously shown that Notch-1 prevents apoptosis and is necessary for pharmacologically induced differentiation in murine erythroleukemia (MEL) cells. We investigated the mechanisms of these effects using three experimental strategies: (1) MEL cells stably transfected with antisense Notch-1 or constitutively active Notch-1, (2) activation of Notch-1 by a cell-associated ligand, and (d3) activation of Notch-1 by a soluble peptide ligand. We show that: (1) downregulation of Notch-1 sensitizes MEL cells to apoptosis induced by a Ca2+ influx or anti-neoplastic drugs; (2) Notch-1 downregulation induces phosphorylation of c-Jun N-terminal kinase (JNK) while constitutive activation of Notch-1 or prolonged exposure to a soluble Notch ligand abolishes it; (3) Notch-1 has dose- and time-dependent effects on the levels of apoptotic inhibitor Bcl-xL and cell cycle regulators p21cip1/waf1, p27kip1, and Rb; and (4) Notch-1 activation by a cell-associated ligand is accompanied by rapid and transient induction of NF-κB DNA-binding activity. The relative effects of Notch-1 signaling on these pathways depend on the levels of Notch-1 expression, the mechanism of activation, and the timing of activation. The relevance of these findings to the role of Notch signaling in differentiation and cancer are discussed. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cellular Physiology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CELL death
KW - CHEMICAL reactions
KW - CELL differentiation
N1 - Accession Number: 12869958; Mei-Shiang Jang 1 Haixi Miao 1 Nadia Carlesso 2 Leslie Shelly 3 Andrei Zlobin 1 Nicole Darack 4 Jian-Zhong Qin Brian J. Nickoloff Lucio Miele 4; Affiliation: 1: Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois 2: AIDS Research Center/Experimental Hematology, Massachusetts General Hospital, Boston, Massachusetts 3: Center for Biologics Evaluation and Research, Division of Monoclonal Antibodies, Bethesda, Maryland 4: Department of Biopharmaceutical Sciences and Cancer Center, University of Illinois at Chicago, Chicago, Illinois; Source Info: Jun2004, Vol. 199 Issue 3, p418; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: CHEMICAL reactions; Subject Term: CELL differentiation; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106601258
T1 - Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned?
AU - Huang S
AU - Lesko LJ
Y1 - 2004/06//
N1 - Accession Number: 106601258. Language: English. Entry Date: 20050401. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Dietary Supplementation -- Adverse Effects
KW - Drug Interactions
KW - Drugs -- Metabolism
KW - Fruit -- Pharmacodynamics
KW - Case Studies
KW - Drug Labeling
KW - Drugs -- Pharmacokinetics
KW - Echinacea -- Pharmacodynamics
KW - Fruit -- Adverse Effects
KW - Genetics
KW - Ginkgo Biloba -- Pharmacodynamics
KW - In Vitro Studies
KW - Isoenzymes -- Drug Effects
KW - Polypharmacy -- Adverse Effects
KW - Research Methodology
KW - Sex Factors
KW - St. John's Wort -- Pharmacodynamics
SP - 559
EP - 569
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 44
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Serious drug-drug interactions have contributed to recent U.S. market withdrawals and also recent nonapprovals of a few new molecular entities. Many of these interactions involved the inhibition or induction of metabolizing enzymes and efflux transporters, resulting in altered systemic exposure and adverse drug reactions or loss of efficacy. In addition to drug-drug interactions, drug-dietary supplement and drug-citrus fruit interactions, among others, could also cause adverse drug reactions or loss of efficacy and are important issues to consider in the evaluation of new drug candidates. This commentary reviews (1). the current understanding of the mechanistic basis of these interactions, (2). issues to consider in the interpretation of study results, and (3). recent labeling examples to illustrate the translation of study results to information useful for patients and health care providers.
SN - 0091-2700
AD - Office of Clinical Pharmacology and Biopharmaceutics, HFD-850, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, PKLN 6A/19, Rockville, MD 20850
U2 - PMID: 15145962.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dwyer, Johanna T.
AU - Picciano, Mary Frances
AU - Betz, Joseph M.
AU - Coates, Paul M.
T1 - Mission and activities of the NIH Office of Dietary Supplements
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2004/06//
VL - 17
IS - 3/4
M3 - Article
SP - 493
EP - 500
SN - 08891575
AB - Major initiatives of the US National Institutes of Health Office of Dietary Supplements (ODS) include development of analytical methods and reference materials to make the development of analytically substantiated dietary supplement databases possible in the future. ODS has an active evidence-based review program focused on efficacy and safety of dietary supplements. It also sponsors basic and clinical research, and information and educational resources, including continuing education conferences and training efforts. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - VITAMINS
KW - EDUCATION
KW - CONTINUING education
KW - Analytical substantiation
KW - Certified Reference Materials
KW - Dietary supplement composition
KW - Dietary supplements
KW - Standard Reference Materials
N1 - Accession Number: 13241909; Dwyer, Johanna T. 1,2; Email Address: Jdwyer1@tufts-nemc.org Picciano, Mary Frances 2 Betz, Joseph M. 3 Coates, Paul M. 2; Affiliation: 1: Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Frances Stern Nutrition Center, Tufts-New England Medical Center, Friedman School of Nutrition Science and Policy, School of Medicine. Boston, MA 02111, USA 2: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA 3: Dietary Supplement Methods and Reference Materials Program, Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Jun2004, Vol. 17 Issue 3/4, p493; Subject Term: DIETARY supplements; Subject Term: VITAMINS; Subject Term: EDUCATION; Subject Term: CONTINUING education; Author-Supplied Keyword: Analytical substantiation; Author-Supplied Keyword: Certified Reference Materials; Author-Supplied Keyword: Dietary supplement composition; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Standard Reference Materials; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jfca.2004.03.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meldrum, R.J.
AU - Tucker, D.
AU - Edwards, C.
T1 - Baseline Rates of Campylobacter and Salmonella in Raw Chicken in Wales, United kingdom, in 2002.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/06//
VL - 67
IS - 6
M3 - Article
SP - 1226
EP - 1228
SN - 0362028X
AB - The Public Health Laboratory Service in Wales, in cooperation with local authorities and the Food Standards Agency Wales, carried out a survey to establish baseline figures for the contamination of raw retail chicken with Salmonella and Campylobacter available within Wales, a devolved part of the United Kingdom with a population of ∼3 million. Seven hundred thirty-nine samples were obtained between November 2001 and December 2002. Overall, 71% of samples were contaminated with Campylobacter, and 8% were contaminated with Salmonella. There were no significant differences between fresh and frozen carcasses and between samples taken from retailers or butchers. There was seasonal variation in the level of Campylobacter contamination of fresh chicken, with a peak in June and the lowest positive rates in January, March, and December. There was no similar peak observed in frozen samples or for Salmonella. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Chickens
KW - Salmonella
KW - Campylobacter
KW - Cooking (Chicken)
KW - Wales
N1 - Accession Number: 13722903; Meldrum, R.J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Tucker, D. 1; Edwards, C. 2; Affiliations: 1: Food, Water and Environmental Section, Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, UK; 2: Caerphilly County Borough Council, Council Offices, Pontlanfraidd, UK; Issue Info: Jun2004, Vol. 67 Issue 6, p1226; Thesaurus Term: Food contamination; Thesaurus Term: Chickens; Thesaurus Term: Salmonella; Thesaurus Term: Campylobacter; Subject Term: Cooking (Chicken); Subject: Wales; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mire-Sluis, Anthony R.
AU - Barrett, Yu Chen
AU - Devanarayan, Viswanath
AU - Koren, Eugene
AU - Liu, Hank
AU - Maia, Mauricio
AU - Parish, Thomas
AU - Scott, George
AU - Shankar, Gopi
AU - Shores, Elizabeth
AU - Swanson, Steven J.
AU - Taniguchi, Gary
AU - Wierda, Daniel
AU - Zuckerman, Linda A.
T1 - Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2004/06//
VL - 289
IS - 1/2
M3 - Article
SP - 1
EP - 16
SN - 00221759
AB - Most biopharmaceutical therapeutics elicit some level of antibody response against the product. This antibody response can, in some cases, lead to potentially serious side effects and/or loss of efficacy. Therefore, the immunogenicity of therapeutic proteins is a concern for clinicians, manufacturers and regulatory agencies. In order to assess immunogenicity of these molecules, appropriate detection, quantitation and characterization of antibody responses are necessary. Inadequately designed antibody assays have led to the hampering of product development or, during licensure, post-marketing commitments. This document provides scientific recommendations based on the experience of the authors for the development of anti-product antibody immunoassays intended for preclinical or clinical studies. While the main focus of this document is assay design considerations, we provide scientific focus and background to the various assay performance parameters necessary for developing a valid assay. Sections on assay performance parameters, including those that appear in regulatory guidances, are contained in this manuscript. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - BIOTECHNOLOGY
KW - THERAPEUTICS
KW - ASSAYING
KW - Antibody
KW - Assays
KW - Immunogenicity
N1 - Accession Number: 13703796; Mire-Sluis, Anthony R. 1; Email Address: mire-sluisa@cder.fda.gov Barrett, Yu Chen 2 Devanarayan, Viswanath 3 Koren, Eugene 4 Liu, Hank 5 Maia, Mauricio 6 Parish, Thomas 7 Scott, George 8 Shankar, Gopi 9 Shores, Elizabeth 10 Swanson, Steven J. 4 Taniguchi, Gary 11 Wierda, Daniel 12 Zuckerman, Linda A. 13; Affiliation: 1: Office of Biotechnology Products, Center for Drug Evaluation and Research, FDA, 5515 Security Lane, HFD-3, Rm 1011, Rockville, MD 20852, USA 2: Bristol-Myers Squibb Company, PO Box 5400 Princeton, NJ 08543, USA 3: Global Statistical Sciences, Lilly Research Labs, DC 2233, Eli Lilly & Co., Indianapolis, IN 46285, USA 4: Clinical Immunology, Amgen Inc., Thousand Oaks, CA 91320, USA 5: Wyeth Pharmaceuticals, 401 N. Middletown Road, Pearl River, NY 10965, USA 6: Preclinical and Clinical Development Sciences, PDL Inc., 34801 Campus Drive Fremont, CA 94555, USA 7: Proctor and Gamble Pharmaceuticals, Route 320 Woods Corners, Norwich NY 13346, USA 8: Ligand Binding Services, MDS Pharma Services, 2350 Cohen Street, St. Laurent, Quebec, Canada H4R 2N6 9: Department of Clinical Pharmacology, CENTOCOR, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA 10: Division of Therapeutic Proteins, CDER, FDA, N29A RM2A01 HFM-538, 8800 Rockville Pike, Bethesda MD 20892, USA 11: Clinical Laboratory Operations, Biomarin Pharmaceutical Inc., 371 Bel Marin Keys Blvd., Novato, CA 94949, USA 12: Department of Immunotoxicology, Eli Lilly & Company, 2001 W Main Street, Greenfield, IN 46140, USA 13: BioAnalytical Research and Development, ZymoGenetics, Inc., Seattle, WA 98102, USA; Source Info: Jun2004, Vol. 289 Issue 1/2, p1; Subject Term: IMMUNOGLOBULINS; Subject Term: BIOTECHNOLOGY; Subject Term: THERAPEUTICS; Subject Term: ASSAYING; Author-Supplied Keyword: Antibody; Author-Supplied Keyword: Assays; Author-Supplied Keyword: Immunogenicity; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.jim.2004.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dybul, Mark
AU - Nies-Kraske,, Elizabeth
AU - Dewar, Robin
AU - Maldarelli, Frank
AU - Hallahan, Calire W.
AU - Daucher, Marybeth
AU - Piscitelli, Stephen C.
AU - Ehler, Linda
AU - Weigand, Ann
AU - Palmer, Sara
AU - Metcalf, Julia A.
AU - Davey, Richard T.
AU - Rock Kress, Diane M.
AU - Powers, April
AU - beck, Ingrid
AU - Frenkel, Lisa
AU - Baseler, Michael
AU - Coffin, John
AU - Fauci, Anthony S.
T1 - A Proof-of-Concept Study of Short-Cycle Intermittent Antiretroviral Therapy with a Once-Daily Regimen of Didanosine, Lamivudine, and Efavirenz for the Treatment of Chronic HIV Infection.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/06//6/1/2004
VL - 189
IS - 11
M3 - Article
SP - 1974
EP - 1982
SN - 00221899
AB - We previously demonstrated that short-cycle structured intermittent therapy (SIT; 7 days without therapy followed by 7 days with antiretroviral therapy [ART]) with a ritonavir-boosted, indinavir-based, twice- daily regimen maintained suppression of plasma HIV viremia while reducing serum levels of lipids. Adherence to such a regimen may be problematic for certain patients. For 7 patients, suppression of plasma HIV RNA to <50 copies/mL was maintained for 60–84 weeks. Four patients with adequate samples had no evidence for an increase in plasma viremia for up to 72 weeks, by use of an assay with a limit of detection of <1 copy/mL. The lack of rebound viremia may be the result of the persistence of efavirenz in plasma on day 7 of the no-therapy period, as was detected in 7 of 7 patients. There was no significant change in CD4+ T cell counts or serum hepatic transaminase or lipid levels. A once-daily short-cycle SIT regimen maintained suppression of plasma HIV RNA while pre- serving CD4+ T cell counts. Such a regimen may have importance in resource-limited settings where the monetary cost of continuous ART is prohibitive. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antiretroviral agents
KW - HIV infections -- Treatment
KW - Lipids
KW - Patient compliance
KW - T cells
KW - Aminotransferases
N1 - Accession Number: 13135889; Dybul, Mark 1; Email Address: mdybul@nih.gov; Nies-Kraske,, Elizabeth 1; Dewar, Robin 2; Maldarelli, Frank 3; Hallahan, Calire W. 1; Daucher, Marybeth 1; Piscitelli, Stephen C. 4; Ehler, Linda 1; Weigand, Ann 3; Palmer, Sara 3; Metcalf, Julia A. 1; Davey, Richard T. 1; Rock Kress, Diane M. 1; Powers, April 1; beck, Ingrid 5; Frenkel, Lisa 5; Baseler, Michael 2; Coffin, John 3; Fauci, Anthony S. 1; Affiliations: 1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, United States Department of Health and Human Services, Bethesda, Maryland; 2: Science Applications International Corporation, Rockville, Maryland; 3: National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland; 4: Tibotec-Virco, Mechelen, Belgium; 5: University of Washington and Children's Hospital, Seattle; Issue Info: 6/1/2004, Vol. 189 Issue 11, p1974; Subject Term: Antiretroviral agents; Subject Term: HIV infections -- Treatment; Subject Term: Lipids; Subject Term: Patient compliance; Subject Term: T cells; Subject Term: Aminotransferases; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Giles, Julie A.
AU - Falconio, Jason
AU - Yuenger, Jeffrey D.
AU - Zenilman, Jonathan M.
AU - Dan, Michael
AU - Bash, Margaret C.
T1 - Quinolone Resistance--Determining Region Mutations and por Type of Neisseria gonorrhoeae Isolates: Resistance Surveillance and Typing by Molecular Methodologies.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/06//6/1/2004
VL - 189
IS - 11
M3 - Article
SP - 2085
EP - 2093
SN - 00221899
AB - Quinolone resistance is increasing rapidly in Neisseria gonorrhoeae and is a significant public health problem that requires ongoing surveillance. To examine the feasibility of molecular surveillance of quinolone resistance, and to further characterize an outbreak of resistant N. gonorrhoeae in Israel, the quinolone resistance determining region (QRDR) sequences and the por types of 80 N. gonorrhoeae isolates were determined using molecular techniques. QRDRs of gyrA and parC were amplified by polymerase chain reaction and were sequenced directly. The por type was determined by checkerboard hybridizations performed using oligonucleotide probes to regions encoding 5 variable loops of the porin protein. All 42 ciprofloxacin-resistant (CipR) isolates had mutations in QRDRs of both gyrA and parC, and identical mutations were found in 93% of these isolates. One intermediately resistant isolate had 1 mutation in gyrA, and susceptible isolates showed no mutations. Forty isolates had 1 of 2 por types that differed only by an in-frame deletion in variable region 5; all but 1 of these isolates were CipR. QRDR sequencing and por type determination showed that the outbreak of CipR N. gonorrhoeae in Israel was clonal. QRDR mutations were consistent with those previously characterized; this indicates that DNA probes can be developed for rapid detection and surveillance of quinolone-resistant N. gonorrhoeae in settings in which nonculture diagnostic methods are used. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Quinolone antibacterial agents
KW - Public health
KW - Microbial mutation
KW - Drug resistance in microorganisms
KW - Neisseria gonorrhoeae
KW - Polymerase chain reaction
KW - Oligonucleotides
KW - DNA probes
KW - Israel
N1 - Accession Number: 13135992; Giles, Julie A. 1; Email Address: jgiles4@jhmi.edu; Falconio, Jason 2,3; Yuenger, Jeffrey D. 1; Zenilman, Jonathan M. 1; Dan, Michael 4; Bash, Margaret C. 2; Affiliations: 1: Division of Allergies and Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland; 2: Division of Bacterial Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland; 3: Montgomery Coutny Public Schools, Maryland; 4: Infectious Disease Unit, Edith Wolfson Hospital, Tel Aviv, Israel; Issue Info: 6/1/2004, Vol. 189 Issue 11, p2085; Thesaurus Term: Quinolone antibacterial agents; Thesaurus Term: Public health; Thesaurus Term: Microbial mutation; Subject Term: Drug resistance in microorganisms; Subject Term: Neisseria gonorrhoeae; Subject Term: Polymerase chain reaction; Subject Term: Oligonucleotides; Subject Term: DNA probes; Subject: Israel; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lulu Xu
AU - Heinze, Tom
AU - Pogge, Amy
AU - Slikker Jr., William
AU - Schmued, Larry
T1 - Isolation and Characterization of Fluoro-Jade B, a Selective Histochemical Stain for Neuronal Degeneration.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 2004/06//
VL - 27
IS - 10
M3 - Article
SP - 1627
EP - 1640
PB - Taylor & Francis Ltd
SN - 10826076
AB - Fluoro-Jade B is a novel fluorescent dye, and since its introduction in 1999 it has been widely used in neuroscience research for selectively staining degenerating neurons in brain tissue sections. However, the chemical composition of Fluoro-Jade B has not been previously resolved. We here report successful separation and identification of eight isomers and structural analogues of Fluoro-Jade B. Two analytical HPLC methods, consisting of a reversed-phase C18 column and a mobile phase with either a pH gradient or an acetonitrile gradient, were developed. A quantitative separation was performed by a semi-preparative reversed phase C18 HPLC column. Each individual component was characterized by LC/ESI mass spectrometry and NMR spectroscopy. The compounds 5-(6'-hydroxy-3'-oxo-3H-xanthen-9'-yl)benzene- 1,2,4-tricarboxylic acid, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-(2,4-dihydroxybenzoyl)terephthalic acid, and 4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-6-(2,4-dihydroxybenzoyl)isophthalic acid represent three new fluorescent compounds discovered in Fluoro-Jade B. They are, presumably, responsible for the dye's ability to detect degenerating neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Liquid Chromatography & Related Technologies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DYES & dyeing
KW - FLUORESCEIN
KW - STAINS & staining (Microscopy)
KW - NEURONS
KW - BRAIN
KW - TISSUES
KW - ISOLATION perfusion (Physiology)
KW - Derivatives of carboxyfluorescein.
KW - Fluorescent dye
KW - Fluoro-Jade B components
KW - Neuronal degeneration
N1 - Accession Number: 13108745; Lulu Xu 1 Heinze, Tom 2 Pogge, Amy 1 Slikker Jr., William 1 Schmued, Larry 1; Email Address: lschmued@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA/USA, Jefferson, Arkansas, USA. 2: Division of Chemistry, National Center for Toxicological Research/FDA/USA, Jefferson, Arkansas, USA.; Source Info: Jun2004, Vol. 27 Issue 10, p1627; Subject Term: DYES & dyeing; Subject Term: FLUORESCEIN; Subject Term: STAINS & staining (Microscopy); Subject Term: NEURONS; Subject Term: BRAIN; Subject Term: TISSUES; Subject Term: ISOLATION perfusion (Physiology); Author-Supplied Keyword: Derivatives of carboxyfluorescein.; Author-Supplied Keyword: Fluorescent dye; Author-Supplied Keyword: Fluoro-Jade B components; Author-Supplied Keyword: Neuronal degeneration; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 14p; Document Type: Article
L3 - 10.1081/JLC-120034096
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei-Lin Wang
AU - Petsonik, Edward L.
T1 - Repeated Measures of FEV1 Over Six to Twelve Months: What Change is Abnormal?
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2004/06//
VL - 46
IS - 6
M3 - Article
SP - 591
EP - 595
SN - 10762752
AB - Monitoring change in FEV1 (ΔFEV1) is useful for assessing adverse respiratory effects in an individual, but high variability impedes reliable recognition of accelerated decline. The American Thoracic Society (ATS) recommends a ≥ 15% year-to-year FEV1 decline for clinical significance. To evaluate the applicability of this criterion in health monitoring programs, we examined the mean, lower 5th percentile, and lower 5% cutoff value of ΔFEV1 determined from 2 tests at 6- and 12-month intervals using data obtained with ATS-recommended equipment and procedures in 389 white male workers, each with 3 to 11 spirometry tests over 5 years. Results indicate that when healthy working males perform spirometry according to ATS standards, a yearly decline in FEV1 greater than 8% or 330 mL should not be considered normal, whereas the 15% ATS criterion could be appropriate in clinical settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL screening
KW - HEALTH promotion
KW - SPIROMETRY
KW - PREVENTIVE health services
KW - PUBLIC health
KW - MEDICAL care
N1 - Accession Number: 13671354; Mei-Lin Wang 1 Petsonik, Edward L. 1; Email Address: elp2@cdc.gov; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention; Source Info: Jun2004, Vol. 46 Issue 6, p591; Subject Term: MEDICAL screening; Subject Term: HEALTH promotion; Subject Term: SPIROMETRY; Subject Term: PREVENTIVE health services; Subject Term: PUBLIC health; Subject Term: MEDICAL care; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1097/01.jom.0000128159.09520.2a
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Owen, S.M.
AU - Rudolph, D.
AU - Wang, W.
AU - Cole, A.M.
AU - Sherman, M.A.
AU - Waring, A.J.
AU - R.I. Lehrer
AU - Lal, R.B.
T1 - A θ-defensin composed exclusively of d-amino acids is active against HIV-1.
JO - Journal of Peptide Research
JF - Journal of Peptide Research
Y1 - 2004/06//
VL - 63
IS - 6
M3 - Article
SP - 469
EP - 476
PB - Wiley-Blackwell
SN - 1397002X
AB - The ability of certain θ-defensins, including retrocyclin-1, to protect human cells from infection by HIV-1 marks them as potentially useful molecules. θ-Defensins composed of l-amino acids are likely to be unstable in environments that contain host and microbial proteases. This study compared the properties of two enantiomeric θ-defensins, retrocyclin-1, and RC-112. Although these peptides have identical sequences, RC-112 is composed exclusively of d-amino acids, whereas retrocyclin-1 contains only l-amino acids. We compared the ability of these peptides to protect JC53-BL human cells from infection by 30 primary HIV-1 isolates. JC53-BL cells are modified HeLa cells that express surface CD4, CXCR4, and CCR5. They also contain reporter cassettes that are driven by the HIV-1 LTR, and express β-galactosidase and luciferase. The HIV-1 isolates varied in co-receptor specificity and included subtypes A, B, C, D, CRF01-AE, and G. RC-112 was several fold more potent than retrocyclin-1 across the entire HIV-1 panel. Although RC-112 bound immobilized gp120 and CD4 with lower affinity than did retrocyclin-1, surface plasmon resonance experiments performed with 1 μg/mL of RC-112 and retrocyclin-1 revealed that both glycoproteins were bound to a similar extent. The superior antiviral performance of RC-112 most likely reflected its resistance to degradation by surface-associated or secreted proteases of the JC53-BL target cells. θ-Defensins composed exclusively of d-amino acids merit consideration as starting points for designing microbicides for topical application to the vagina or rectum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Peptide Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - HIV infections
KW - MOLECULES
KW - PEPTIDES
KW - HELA cells
KW - GLYCOPROTEINS
KW - enantiopeptide
KW - HIV-1
KW - retrocyclin
N1 - Accession Number: 13229402; Owen, S.M. 1; Email Address: smo2@cdc.gov Rudolph, D. 1 Wang, W. 2 Cole, A.M. 2 Sherman, M.A. 3 Waring, A.J. 2 R.I. Lehrer 2 Lal, R.B. 1; Affiliation: 1: HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research National center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Public Health Services, US Department of Health and Human Services, Atlanta, GA 30333, USA 2: Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA 3: Division of Biomedical Informatics, City of Hope National Medical Center, Duarte, CA 91010, USA; Source Info: Jun2004, Vol. 63 Issue 6, p469; Subject Term: AMINO acids; Subject Term: HIV infections; Subject Term: MOLECULES; Subject Term: PEPTIDES; Subject Term: HELA cells; Subject Term: GLYCOPROTEINS; Author-Supplied Keyword: enantiopeptide; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: retrocyclin; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1399-3011.2004.00155.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Matthew R.
T1 - Transient temperature rise due to ultrasound absorption at a bone/soft-tissue interface.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2004/06//
VL - 115
IS - 6
M3 - Article
SP - 2887
EP - 2891
SN - 00014966
AB - Thermal effects due to high ultrasound absorption in bone pose an ongoing safety issue. Of considerable concern is the heating of the soft tissue adjacent to the bone surface. Mathematical models can be useful in predicting the transient temperature near the interface during insonation. This paper develops a model that provides the temperature field in terms of simple expressions that convey the functional dependence of the material properties, and are easily incorporated into standards and ultrasound machine software, yet are able to incorporate the material properties of both bone and soft tissue. The model contains an asymptotic theory based upon a "high-attenuation" assumption: the distance diffused by heat over the time of interest is large compared to the ultrasound attenuation length. Model predictions of temperature rise and location of maximum temperature were in close agreement with finite-element calculations, using parameters appropriate for radiation-force imaging and focused-ultrasound surgery. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGING systems in medicine
KW - MATHEMATICAL models
KW - BONE
KW - TISSUES
KW - MEDICAL equipment
N1 - Accession Number: 20805180; Myers, Matthew R. 1; Affiliation: 1: Center for Devices and Radiological Health, HFZ-132, U. S. Food and Drug Administration, Rockville, Maryland 20852; Source Info: Jun2004, Vol. 115 Issue 6, p2887; Subject Term: IMAGING systems in medicine; Subject Term: MATHEMATICAL models; Subject Term: BONE; Subject Term: TISSUES; Subject Term: MEDICAL equipment; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 5p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1121/1.1707091
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, Gerald R.
AU - Gammell, Paul M.
T1 - 1-3 piezoelectric composite transducers for swept-frequency calibration of hydrophones from 100 kHz to 2 MHz.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2004/06//
VL - 115
IS - 6
M3 - Article
SP - 2914
EP - 2918
SN - 00014966
AB - Rapid calibration of hydrophones used in biomedical ultrasound is possible with swept frequency techniques such as time delay spectrometry. However, calibrations below 2 MHz largely have been neglected because of insufficient transmitting transducer bandwidth, even though important medical applications operate in this range. To address this deficiency, several transmitting transducer designs were developed and tested, and two 1-3 piezoelectric composite designs were found to have the requisite bandwidth and uniformity of response. In one the element has a plane front face and spherically concave back face (plano-concave), and in the second both faces are concave, but with different radii of curvature (biconcave). The nonuniform thickness disperses the thickness resonance, and the composite structure suppresses radial-mode resonances. Also, the composite's lower acoustic impedance provides a more efficient match to water. The piezoelectric composite transducers were found to have transmitting pressure sensitivities superior to ceramic single-element and segmented designs having similar dimensions, and their responses were significantly more uniform (<25 dB variation from 0.1-2 MHz, with ,1 dB fine structure variation), likely due to decreased contributions from radial modes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROPHONE
KW - ELECTROACOUSTIC transducers
KW - SOUND -- Equipment & supplies
KW - PIEZOELECTRIC transducers
KW - PIEZOELECTRIC devices
N1 - Accession Number: 20805183; Harris, Gerald R. 1; Email Address: gerald.harris@fda.hhs.gov Gammell, Paul M. 2; Affiliation: 1: Food and Drug Administration, 9200 Corporate Boulevard, Rockville, Maryland 20850 2: Gammell Applied Technologies, LLC, 6139 Pleasant Cove Drive, Exmore, Virginia 23350; Source Info: Jun2004, Vol. 115 Issue 6, p2914; Subject Term: HYDROPHONE; Subject Term: ELECTROACOUSTIC transducers; Subject Term: SOUND -- Equipment & supplies; Subject Term: PIEZOELECTRIC transducers; Subject Term: PIEZOELECTRIC devices; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; Number of Pages: 5p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1121/1.1707090
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106770390
T1 - 2000-2001 Food Label and Package Survey: an update on prevalence of nutrition labeling and claims on processed, packaged foods.
AU - LeGault L
AU - Brandt MB
AU - McCabe N
AU - Adler C
AU - Brown A
AU - Brecher S
Y1 - 2004/06//
N1 - Accession Number: 106770390. Language: English. Entry Date: 20040827. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Food Labeling -- Evaluation
KW - Consumer Health Information
KW - Nutrients
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 952
EP - 958
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 104
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Nutritionist, Food and Drug Administration, Center for Food Safety and Applied Nutrition (HFS-840), 5100 Paint Branch Parkway, College Park, MD 20740; llegault@cfsan.fda.gov
U2 - PMID: 15175594.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106770390&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Robert, Elizabeth S.
AU - Charboneau, Lu
AU - Espina, Virginia
AU - Liotta, Lance A.
AU - Petricoin III, Emmanuel F.
AU - Dreher, Kevin L.
T1 - Application of Laser Capture Microdissection and Protein MicroArray Technologies in the Molecular Analysis of Airway Injury Following Pollution Particle Exposure.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/06//
VL - 67
IS - 11
M3 - Article
SP - 851
EP - 861
SN - 15287394
AB - Understanding the mechanisms by which various types of air pollution particles (particulate matter, PM) mediate adverse health effects would provide biological plausibility to epidemiological associations of increased rates of morbidity and mortality. The majority of information regarding the means by which PM generates lung injury has been derived from in vitro studies. However, it is unclear as to what extent these mechanisms can be extrapolated to the in vivo situation. Current methods to assess mechanisms of PM-induced lung injury make it difficult to obtain site-specific, sensitive, and comprehensive determinations of cellular and molecular pathology associated with PM-induced injury. In the present study, the ability of laser capture microdissection (LCM) and protein microarray technologies were assessed to examine the effect of residual oil fly ash (ROFA) exposure on airway intracellular signaling pathways and transcription factor activation. Sprague-Dawley rats were intratracheally instilled with 0.5 mg/rat of ROFA. LCM was used to recover airway cells and protein extracts derived from the microdissected airways were analyzed by protein microarray. ROFA exposure increased p-ERK:ERK and p-I κ B:I κ B, suggesting changes in cell growth, transformation, and inflammation within the airway. These results are consistent with previously reported in vitro findings, demonstrating for the first time the credibility of applying LCM and protein microarray technologies to assess acute lung injury induced by environmental air pollutants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLLUTANTS
KW - AIR pollution
KW - LUNGS -- Wounds & injuries
KW - MOLECULAR pathology
KW - MICRODISSECTION
KW - MICRODISSECTION -- Instruments
N1 - Accession Number: 12888632; Robert, Elizabeth S. 1 Charboneau, Lu 2 Espina, Virginia 2 Liotta, Lance A. 2 Petricoin III, Emmanuel F. 3 Dreher, Kevin L. 4; Email Address: DREHER.KEVIN@EPA.GOV; Affiliation: 1: Depatment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA 2: National Center Institute, National Institutes of Health, Bethesda, Maryland, USA 3: U.S. Food and Drug Administration, CBER, Rockville, Maryland, USA 4: U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA; Source Info: 2004, Vol. 67 Issue 11, p851; Subject Term: POLLUTANTS; Subject Term: AIR pollution; Subject Term: LUNGS -- Wounds & injuries; Subject Term: MOLECULAR pathology; Subject Term: MICRODISSECTION; Subject Term: MICRODISSECTION -- Instruments; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Mihi
AU - Coles, Brian F.
AU - Caporaso, Neil E.
AU - Choi, Yunhee
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism
JO - Lung Cancer (01695002)
JF - Lung Cancer (01695002)
Y1 - 2004/06//
VL - 44
IS - 3
M3 - Article
SP - 281
EP - 286
SN - 01695002
AB - The formation of DNA adducts is thought to be a critical step for the induction of chemically induced cancer. O6-Methylguanine-DNA methyltransferase (MGMT) is a ubiquitously expressed enzyme that repairs DNA adducts formed by alkylating carcinogens. Thus, genetic polymorphisms of the MGMT that could result in differences in MGMT activity are potential risk factors for cancer. In the present study, we established a convenient and reliable genotyping method for the MGMT codon 178 polymorphism, a Lys (AAG) to Arg (AGG) substitution, using restriction fragment length polymorphism (RFLP), and studied differences in the distribution of this polymorphism in 92 Caucasian lung cancer patients and 85 controls. Frequencies of the “A” and “G” alleles (MGMT codon 178, AAG and AGG, respectively) were 0.91 and 0.09, respectively. The genetic polymorphism of the MGMT codon 178 was linked with that of the MGMT codon 143 (P<0.05 ). The distribution of the MGMT codon 178 genetic polymorphism was not significantly different between lung cancer patients and controls. Thus, our study suggests that the MGMT codon 178 (and possibly 143) polymorphisms do not appear to markedly affect lung cancer risk for this population. In addition, we found an apparent 10 bp-deletion in the intron before exon 5 by DNA sequencing. Because this “deletion” was observed in all sequenced samples (N=20 ), the previously reported human (Caucasian) MGMT gene sequence should be revised to exclude this 10 bp segment. [Copyright &y& Elsevier]
AB - Copyright of Lung Cancer (01695002) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Cancer
KW - RISK
KW - DNA
KW - ENZYMES
KW - Codon 178
KW - Genetic polymorphism
KW - Lung cancer
KW - MGMT
KW - RFLP
N1 - Accession Number: 13114842; Yang, Mihi 1,2; Email Address: myang@snu.ac.kr Coles, Brian F. 2 Caporaso, Neil E. 3 Choi, Yunhee 1 Lang, Nicholas P. 4 Kadlubar, Fred F. 2; Affiliation: 1: Department of Preventive Medicine, Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon-dong, Chongno-gu, 110-799, Seoul, South Korea 2: Division of Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Drive, Jefferson, AR 72079, USA 3: National Cancer Institute, NIH, Bethesda, MD 20892, USA 4: Central Arkansas Veterans Health Care System, 4300 West 7th, Little Rock, AR 72205, USA; Source Info: Jun2004, Vol. 44 Issue 3, p281; Subject Term: LUNGS -- Cancer; Subject Term: RISK; Subject Term: DNA; Subject Term: ENZYMES; Author-Supplied Keyword: Codon 178; Author-Supplied Keyword: Genetic polymorphism; Author-Supplied Keyword: Lung cancer; Author-Supplied Keyword: MGMT; Author-Supplied Keyword: RFLP; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.lungcan.2003.12.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Friedman, Bernard
AU - Basu, Jayasree
T1 - The Rate and Cost of Hospital Readmissions for Preventable Conditions.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2004/06//
VL - 61
IS - 2
M3 - Article
SP - 225
EP - 240
SN - 10775587
AB - The study estimates the rate and cost of preventable readmissions within 6 months after a first preventable admission, by age-group, and by payer and race within age-group. The descriptive results are contrasted with several hypotheses. The hospital discharge data are for residents of New York, Pennsylvania, Tennessee, and Wisconsin in 1999, from files of the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality. About 19 percent of persons with an initial preventable admission had at least one preventable readmission rate within 6 months. Hospital cost for preventable readmissions during 6 months was about $730 million. There were substantial differences in readmission rates by payer group and by race. Some evidence suggests that preventable readmissions may partly reflect complexity of underlying problems. Interventions to reduce cost might focus on identifying high-risk patients before discharge and devising new approaches to follow-up. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MEDICAL care
KW - HOSPITAL costs
KW - PATIENTS
KW - UNITED States
KW - cost
KW - Healthcare Cost and Utilization
KW - PQI
KW - preventable readmissions
KW - Project
N1 - Accession Number: 13376214; Friedman, Bernard 1 Basu, Jayasree 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Jun2004, Vol. 61 Issue 2, p225; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care; Subject Term: HOSPITAL costs; Subject Term: PATIENTS; Subject Term: UNITED States; Author-Supplied Keyword: cost; Author-Supplied Keyword: Healthcare Cost and Utilization; Author-Supplied Keyword: PQI; Author-Supplied Keyword: preventable readmissions; Author-Supplied Keyword: Project; Number of Pages: 16p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1177/1077558704263799
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13376214&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BRIAN D. LOWE
T1 - Effect of Bicycle Saddle Designs on the Pressure to the Perineum of the Bicyclist.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2004/06//
VL - 36
IS - 6
M3 - Article
SP - 1055
EP - 1062
SN - 01959131
AB - LOWE, B. D., S. M. SCHRADER, and M. J. BREITENSTEIN. Effect of Bicycle Saddle Designs on the Pressure to the Perineum of the Bicyclist. Med. Sci. Sports Exerc., Vol. 36, No. 6, pp. 1055'''1062, 2004. PURPOSE:: Increasing awareness of an association between bicycling and male sexual dysfunction has led to the appearance of a variety of bicycle saddles that share the design objective of reducing pressure in the groin of the cyclist by removal of the narrow protruding nose of the saddle. This study compared three of these saddle designs to a traditional sport/road racing saddle with a narrow protruding nose in terms of pressure in the region of the perineum (groin) of the cyclist. METHODS:: Saddle, pedal, and handlebar contact pressure were measured from 33 bicycle police patrol officers pedaling a stationary bicycle at a controlled cadence and workload. Pressure was characterized over the saddle as a whole and over a region of the saddle assumed to represent pressure on the cyclist'''s perineum located anteriorly to the ischial tuberosities. RESULTS:: The traditional sport/racing saddle was associated with more than two times the pressure in the perineal region than the saddles without a protruding nose (P < 0.01). There were no significant differences in perineal pressure among the nontraditional saddles. Measures of load on the pedals and handlebars indicated no differences between the traditional saddle and those without protruding noses. This finding is contradictory to those studies suggesting a shift toward greater weight distribution on the handlebars and pedals when using a saddle without a nose. CONCLUSIONS:: The recommendation of a saddle without a narrow protruding nose appears to be justified to reduce pressure to the perineum of the bicyclist. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medicine & Science in Sports & Exercise is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLING
KW - PERINEAL care
KW - SEXUAL dysfunction
KW - SPORTS sciences
N1 - Accession Number: 13498404; BRIAN D. LOWE 1; Affiliation: 1: Human Factors and Ergonomics Research Section; and Reproductive Health Assessment Section, National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: Jun2004, Vol. 36 Issue 6, p1055; Subject Term: CYCLING; Subject Term: PERINEAL care; Subject Term: SEXUAL dysfunction; Subject Term: SPORTS sciences; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106567530
T1 - Effect of bicycle saddle designs on the pressure to the perineum of the bicyclist.
AU - Lowe BD
AU - Schrader SM
AU - Breitenstein MJ
Y1 - 2004/06//
N1 - Accession Number: 106567530. Language: English. Entry Date: 20050128. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8005433.
KW - Bicycles
KW - Equipment Design
KW - Pressure (Physiology)
KW - Perineum
KW - Biomechanics
KW - Male
KW - Female
KW - Men's Health
KW - Comparative Studies
KW - Police
KW - Ergometry
KW - Exercise Test
KW - Groin
KW - Exercise Physiology
KW - Random Assignment
KW - Body Weights and Measures
KW - Descriptive Statistics
KW - Self Report
KW - Time Factors
KW - Biophysiological Methods
KW - Mathematics
KW - Biophysical Instruments
KW - Spectral Analysis
KW - Post Hoc Analysis
KW - Analysis of Covariance
KW - Human
SP - 1055
EP - 1062
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
JA - MED SCI SPORTS EXERC
VL - 36
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE: Increasing awareness of an association between bicycling and male sexual dysfunction has led to the appearance of a variety of bicycle saddles that share the design objective of reducing pressure in the groin of the cyclist by removal of the narrow protruding nose of the saddle. This study compared three of these saddle designs to a traditional sport/road racing saddle with a narrow protruding nose in terms of pressure in the region of the perineum (groin) of the cyclist. METHODS: Saddle, pedal, and handlebar contact pressure were measured from 33 bicycle police patrol officers pedaling a stationary bicycle at a controlled cadence and workload. Pressure was characterized over the saddle as a whole and over a region of the saddle assumed to represent pressure on the cyclist's perineum located anteriorly to the ischial tuberosities. RESULTS: The traditional sport/racing saddle was associated with more than two times the pressure in the perineal region than the saddles without a protruding nose (P < 0.01). There were no significant differences in perineal pressure among the nontraditional saddles. Measures of load on the pedals and handlebars indicated no differences between the traditional saddle and those without protruding noses. This finding is contradictory to those studies suggesting a shift toward greater weight distribution on the handlebars and pedals when using a saddle without a nose. CONCLUSIONS: The recommendation of a saddle without a narrow protruding nose appears to be justified to reduce pressure to the perineum of the bicyclist.
SN - 0195-9131
AD - Human Factors and Ergonomics Research Section, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226; blowe@cdc.gov
U2 - PMID: 15179177.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106567530&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Effect of bicycle saddle designs on the pressure to the perineum of the bicyclist.
AU - Lowe, B.D.
AU - Schrader, S.M.
AU - Breitenstein, M.J.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2004/06//
VL - 36
IS - 6
SP - 1055
EP - 1062
CY - ;
SN - 01959131
N1 - Accession Number: SPHS-954204; Author: Lowe, B.D.: 1 email: blowe@cdc.gov. Author: Schrader, S.M.: 2 Author: Breitenstein, M.J.: 3 ; Author Affiliation: 1 Human Factors and Ergonomics Research Section, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226: 2 Reproductive Health Assessment Section, National Institute for Occupational Safety and Health, 4676 Columbia parkway, MS C-24, Cincinnati, OH 45226: 3 Reproductive Health Assessment Section, National Institute for Occupational Safety and Health, 4676 Columbia parkway, MS C-24, Cincinnati, OH 45226; No. of Pages: 8; Language: English; Parent Item: SPHP1978; References: 22; General Notes: Applied sciences: physical fitness and performance.; Publication Type: Article; Update Code: 20050101; SIRC Article No.: S-954204
N2 - Purpose: Increasing awareness of an association between bicycling and male sexual dysfunction has led to the appearance of a variety of bicycle saddles that share the design objective of reducing pressure in the groin of the cyclist by removal of the narrow protruding nose of the saddle. This study compared three of these saddle designs to a traditional sport/road racing saddle with a narrow protruding nose in terms of pressure in the region of the perineum (groin) of the cyclist. Methods: Saddle, pedal, and handlebar contact pressure were measured from 33 bicycle police patrol officers pedaling a stationary bicycle at a controlled cadence and workload. Pressure was characterized over the saddle as a whole and over a region of the saddle assumed to represent pressure on the cyclist's perineum located anteriorly to the ischial tuberosities. Results: The traditional sport/racing saddle was associated with more than two times the pressure in the perineal region than the saddles without a protruding nose (P < 0.01). There were no significant differences in perineal pressure among the nontraditional saddles. Measures of load on the pedals and handlebars indicated no differences between the traditional saddle and those without protruding noses. This finding is contradictory to those studies suggesting a shift toward greater weight distribution on the handlebars and pedals when using a saddle without a nose. Conclusions: The recommendation of a saddle without a narrow protruding nose appears to be justified to reduce pressure to the perineum of the bicyclist.
KW - *CYCLING -- Equipment & supplies
KW - *CYCLING
KW - *SADDLERY
KW - *GROIN
KW - *PENIS
KW - *NEUROPATHY
KW - COMPARATIVE studies
KW - DESIGN
L2 - http://articles.sirc.ca/search.cfm?id=S-954204
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UR - http://articles.sirc.ca/search.cfm?id=S-954204
UR - http://www.wwilkins.com
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Smith, Jeffrey S.
AU - Tian, Jie
AU - Lozier, Jay N.
AU - Byrnes, Andrew P.
T1 - Severe pulmonary pathology after intravenous administration of vectors in cirrhotic rats
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2004/06//
VL - 9
IS - 6
M3 - Article
SP - 932
EP - 941
SN - 15250016
AB - After an intravascular injection, adenoviral vectors are normally taken up by the reticuloendothelial system in the liver, where they rapidly trigger an innate response. However, we have previously found that the biodistribution of adenoviral vectors is altered in cirrhotic rats due to the presence of pulmonary intravascular macrophages, which cause a shift in vector uptake from the liver to the lungs. We now report that this is correlated with fatal pulmonary hemorrhagic edema in cirrhotic rats. In addition, cirrhotic rats reacted to vector with enormous increases in TNF-α and IL-6 and markedly prolonged coagulation times. Although we also saw fatal reactions to high doses of adenoviral vectors in normal rats, the time course and symptoms were very different, and pulmonary hemorrhagic edema was seen only in cirrhotic rats. Because abnormal pulmonary reticuloendothelial uptake is known to occur in humans during cirrhosis and other diseases, there is the potential that intravascular administration of adenoviral vectors might cause lung pathology in such patients. [Copyright &y& Elsevier]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE therapy
KW - EDEMA
KW - LUNGS
KW - THERAPEUTICS
KW - adenovirus
KW - cirrhosis
KW - coagulopathy
KW - edema
KW - gene therapy
KW - hemorrhage
KW - lung
KW - pulmonary intravascular macrophage
N1 - Accession Number: 13390885; Smith, Jeffrey S. 1 Tian, Jie 1 Lozier, Jay N. 2 Byrnes, Andrew P. 1; Email Address: byrnesa@cber.fda.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jun2004, Vol. 9 Issue 6, p932; Subject Term: GENE therapy; Subject Term: EDEMA; Subject Term: LUNGS; Subject Term: THERAPEUTICS; Author-Supplied Keyword: adenovirus; Author-Supplied Keyword: cirrhosis; Author-Supplied Keyword: coagulopathy; Author-Supplied Keyword: edema; Author-Supplied Keyword: gene therapy; Author-Supplied Keyword: hemorrhage; Author-Supplied Keyword: lung; Author-Supplied Keyword: pulmonary intravascular macrophage; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ymthe.2004.03.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slikker Jr., William
AU - Pogge, Amy
AU - Walker, Ronald
AU - Chatziiannou, Arion
AU - Charles, Cecil
AU - Ellisman, Mark
T1 - Neuroimaging: Strategies to Illuminate Environment-Disease Linkages: Session II. Summary and Research Needs
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2004/06//
VL - 25
IS - 4
M3 - Article
SP - 501
EP - 502
SN - 0161813X
N1 - Accession Number: 13332768; Slikker Jr., William 1 Pogge, Amy 1; Email Address: wslikker@nctr.fda.gov Walker, Ronald 2 Chatziiannou, Arion 3 Charles, Cecil 4 Ellisman, Mark 5; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of PET Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3: Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA 4: Duke Image Analysis Laboratory, Duke University, Durham, NC 27708, USA 5: National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA; Source Info: Jun2004, Vol. 25 Issue 4, p501; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.neuro.2003.09.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowyer, John F.
AU - Harris, Angela J.
AU - Delongchamp, Robert R.
AU - Jakab, Robert L.
AU - Miller, Diane B.
AU - Little, A. Roger
AU - O’Callaghan, James P.
T1 - Selective Changes in Gene Expression in Cortical Regions Sensitive to Amphetamine During the Neurodegenerative Process
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2004/06//
VL - 25
IS - 4
M3 - Article
SP - 555
EP - 572
SN - 0161813X
AB - Gene expression profiles in several brain regions of adult male rats were evaluated following a d-amphetamine (AMPH) exposure paradigm previously established to produce AMPH neurotoxicity. Escalating doses of AMPH (5–30 mg/kg) were given over the course of 16 h per day in an 18 °C environment for 2 days. This paradigm produces neurotoxicity but eliminates or minimizes the hyperthermia and seizure activity that might influence gene expression in a manner unrelated to the neurotoxic effects of AMPH. The expression of 1185 genes was monitored in the striatum, parietal cortex, piriform cortex and posteriolateral cortical amygdaloid nucleus (PLCo) using cDNA array technology, and potentially significant changes were verified by RT–PCR. Gene expression was determined at time points after AMPH when neurodegeneration was beginning to appear (16 h) or maximal (64 h). Expression was also determined 14 days after AMPH to find long-term changes in gene expression that might be biomarkers of a neurotoxic event. In the parietal cortex there was a two-fold increase in neuropeptide Y precursor protein mRNA whereas nerve growth factor-induced receptor protein I-A and I-B mRNA decreased 50% at 16 h after the end of AMPH exposure. Although these changes in expression were not observed in the PLCo, insulin-like growth factor binding protein 1 mRNA was increased two-fold in the PLCo at 16 and 64 h after AMPH. Changes in gene expression in the cortical regions were all between 1.2- and 1.5-fold 14 days after AMPH but some of these changes, such as annexin V increases, may be relevant to neurotoxicity. Gene expression was not affected by more than 1.5-fold at the time points in the striatum, although 65% dopamine depletions occurred, but the plasma membrane-associated dopamine transporter and dopamine D2 receptor were decreased about 40% in the substantia nigra at 64 h and 14 days post-AMPH. Thus, the 2-day AMPH treatment produced a few changes in gene expression in the two-fold range at time points 16 h or more after exposure but the majority of expression changes were less than 1.5-fold of control. Nonetheless, some of these lesser fold-changes appeared to be relevant to the neurotoxic process. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - AMPHETAMINES
KW - NEUROTOXICOLOGY
KW - FEVER
KW - DNA
KW - Amphetamine
KW - Gene expression
KW - Neurodegeneration
N1 - Accession Number: 13332778; Bowyer, John F. 1; Email Address: jbowyer@nctr.fda.gov Harris, Angela J. 1 Delongchamp, Robert R. 1 Jakab, Robert L. 1 Miller, Diane B. 2 Little, A. Roger 2 O’Callaghan, James P. 2; Affiliation: 1: Divisions of Neurotoxicology, Biometry and Risk Assessment and Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Centers for Disease Control and Prevention-NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Jun2004, Vol. 25 Issue 4, p555; Subject Term: GENE expression; Subject Term: AMPHETAMINES; Subject Term: NEUROTOXICOLOGY; Subject Term: FEVER; Subject Term: DNA; Author-Supplied Keyword: Amphetamine; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Neurodegeneration; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.neuro.2003.08.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goe, S. K.
AU - Henneberger, P. K.
AU - Filios, M. S.
AU - Reilly, M. J.
AU - Rosenman, K. D.
AU - Schill, D. P.
AU - Valiante, D.
AU - Flattery, J.
AU - Harrison, R.
AU - Reinisch, F.
AU - Tumpowsky, C.
T1 - A descriptive study of work aggravated asthma.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2004/06//
VL - 61
IS - 6
M3 - Article
SP - 512
EP - 517
SN - 13510711
AB - Background and Aims: Work related asthma (WRA) is one of the most frequently reported occupational lung diseases in a number of industrialised countries. A better understanding of work aggravated asthma (WAA), as well as work related new onset asthma (NOA), is needed to aid in prevention efforts. Methods: WAA and NOA in the United States were compared using cases reported to the National Institute for Occupational Safety and Health (NIOSH) from four state Sentinel Event Notification Systems for Occupational Risks (SENSOR) surveillance programmes for 1993-95. Results: A total of 210 WAA cases and 891 NOA cases were reported. WAA cases reported mineral and inorganic dusts as the most common exposure agent, as opposed to NOA cases, in which diisocyanates were reported most frequently. A similar percentage of WAA and NOA cases still experienced breathing problems at the time of the interview or had visited a hospital of emergency room for work related breathing problems. NOA cases were twice as likely to have applied for workers' compensation compared with WAA cases. However, among those who had applied for worker compensation, approximately three-fourths of both WAA and NOA cases had received awards. The services and manufacturing industrial categories together accounted for the majority of both WAA (62%) and NOA (75%) cases. The risk of WAA, measured by average annual rate, was clearly the highest in the public administration (14.2 cases/105) industrial category, while the risk of NOA was increased in both the manufacturing (3.2 cases/105) and public administration (2.9 cases/105) categories. Conclusions: WAA cases reported many of the same adverse consequences as NOA cases. Certain industries were identified as potential targets for prevention efforts based on either the number of cases of the risk of WAA and NOA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Occupational diseases
KW - Prevention
KW - Lung diseases
KW - United States
N1 - Accession Number: 13640268; Goe, S. K. 1; Henneberger, P. K. 1; Email Address: pkh0@cdc.gov; Filios, M. S. 1; Reilly, M. J. 2; Rosenman, K. D. 2; Schill, D. P. 3; Valiante, D. 3; Flattery, J. 4; Harrison, R. 4; Reinisch, F. 4; Tumpowsky, C. 5; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, WV, USA; 2: Michigan State University, East Lansing, MI, USA; 3: New Jersey Department of Health and Senior Services, Trenton, NJ, USA; 4: California Department of Health Services, Sacramento, CA, USA; 5: Massachusetts Department of Public Health, Boston, MA, USA; Issue Info: Jun2004, Vol. 61 Issue 6, p512; Thesaurus Term: Asthma; Thesaurus Term: Occupational diseases; Subject Term: Prevention; Subject Term: Lung diseases; Subject: United States; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1136/oem.2003.008177
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106586686
T1 - A descriptive study of work aggravated asthma.
AU - Goe SK
AU - Henneberger PK
AU - Reilly MJ
AU - Rosenman KD
AU - Schill DP
AU - Valiante D
AU - Flattery J
AU - Harrison R
AU - Reinisch F
AU - Tumpowsky C
AU - Filios MS
Y1 - 2004/06//
N1 - Accession Number: 106586686. Language: English. Entry Date: 20050225. Revision Date: 20150711. Publication Type: Journal Article; forms; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Air Pollutants, Occupational -- Adverse Effects
KW - Asthma -- Etiology
KW - Dust
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Adult
KW - Asthma -- Epidemiology
KW - Asthma -- Prevention and Control
KW - Chi Square Test
KW - Descriptive Statistics
KW - Disease Surveillance
KW - Epidemiological Research
KW - Female
KW - Fisher's Exact Test
KW - Incidence
KW - Male
KW - National Institute for Occupational Safety and Health -- Standards
KW - Occupational Diseases -- Epidemiology
KW - Statistical Significance
KW - T-Tests
KW - United States
KW - Human
SP - 512
EP - 517
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 61
IS - 6
PB - BMJ Publishing Group
AB - BACKGROUND AND AIMS: Work related asthma (WRA) is one of the most frequently reported occupational lung diseases in a number of industrialised countries. A better understanding of work aggravated asthma (WAA), as well as work related new onset asthma (NOA), is needed to aid in prevention efforts. METHODS: WAA and NOA in the United States were compared using cases reported to the National Institute for Occupational Safety and Health (NIOSH) from four state Sentinel Event Notification Systems for Occupational Risks (SENSOR) surveillance programmes for 1993-95. RESULTS: A total of 210 WAA cases and 891 NOA cases were reported. WAA cases reported mineral and inorganic dusts as the most common exposure agent, as opposed to NOA cases, in which diisocyanates were reported most frequently. A similar percentage of WAA and NOA cases still experienced breathing problems at the time of the interview or had visited a hospital or emergency room for work related breathing problems. NOA cases were twice as likely to have applied for workers' compensation compared with WAA cases. However, among those who had applied for worker compensation, approximately three-fourths of both WAA and NOA cases had received awards. The services and manufacturing industrial categories together accounted for the majority of both WAA (62%) and NOA (75%) cases. The risk of WAA, measured by average annual rate, was clearly the highest in the public administration (14.2 cases/10(5)) industrial category, while the risk of NOA was increased in both the manufacturing (3.2 cases/10(5)) and public administration (2.9 cases/10(5)) categories. CONCLUSIONS: WAA cases reported many of the same adverse consequences as NOA cases. Certain industries were identified as potential targets for prevention efforts based on either the number of cases or the risk of WAA and NOA.
SN - 1351-0711
AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS H-2800 Morgantown, WV 26505; pkh0@cdc.gov
U2 - PMID: 15150390.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106667102
T1 - Culture-specific diabetes care for Surinam South Asians with a low socio-economic position: who benefits?
AU - Middelkoop BJC
AU - van der Wal G
Y1 - 2004/06//
N1 - Accession Number: 106667102. Language: English. Entry Date: 20041126. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Core Nursing; Europe; Health Promotion/Education; Nursing; Peer Reviewed; UK & Ireland. Grant Information: Vrije Universiteit Amsterdam, the Hague Green Cross Fund and the Municipality of The Hague. NLM UID: 8406280.
KW - Asians -- Netherlands
KW - Cultural Sensitivity
KW - Diabetes Mellitus -- Therapy
KW - Body Mass Index
KW - Clinical Trials
KW - Female
KW - Funding Source
KW - Glycemic Control
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Netherlands
KW - Odds Ratio
KW - South America -- Ethnology
KW - T-Tests
KW - Univariate Statistics
KW - Human
SP - 353
EP - 358
JO - Patient Education & Counseling
JF - Patient Education & Counseling
JA - PATIENT EDUC COUNS
VL - 53
IS - 3
PB - Elsevier Science
SN - 0738-3991
AD - Department of Epidemiology, Public Health Service, (GGD) PO Box 12 652, 2500 DP The Hague, The Netherlands; b.j.c.middelkoop@ocw.denhaag.nl
U2 - PMID: 15186874.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miller, Marlene R.
AU - Zhan, Chunliu
T1 - Pediatric Patient Safety in Hospitals: A National Picture in 2000.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/06//
VL - 113
IS - 6
M3 - Article
SP - 1741
EP - 1746
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. To describe potential patient safety events for hospitalized children, examine associ-ated factors, and explore impacts of safety events. Methods. The newly released Patient Safety Indica-tors (PSIs), developed by researchers at the Agency for Healthcare Research and Quality to identify potential in-hospital patient safety problems using administrative data, were applied to hospital discharge data. All 5.7 million discharge records for children younger than 19 years from 27 states in the 2000 Healthcare Cost and Utilization Project were analyzed for PSI events. Preva-lence of PSI events and associations with patient-level and hospital-level characteristics were examined. Multi-variate regression adjusting for patient severity of illness was used to estimate impacts of safety events in terms of excess length of stay, charges, and in-hospital mortality. Results. The prevalence of pediatric patient safety events is significant. PSI events occurred more fre-quently in the very young and those on Medicaid insur-ance, some of the most vulnerable hospitalized children. Regression analysis found that almost all PSIs are asso-ciated with significant and substantial increases in length of stay, charges, and in-hospital death. Using the estimates derived here and the actual number of cases identified in the 2000 data, we estimate that patient safety events incurred >$1 billion in excess charges for children alone in 2000. Conclusions. Patient safety problems for hospitalized children occur frequently and with substantial impacts to our health care industry. Unmeasurable by this study are the additional "costs" and"burdens"of safety events that our patients are forced to handle. Additional work to describe and quantify better these outcomes in addition to ones measured here can help solidify the"business case" for patient safety efforts. Pediatrics 2004;113: 1741--1746; safety, quality of health care, medical error, infant,... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN'S hospitals
KW - PEDIATRICS
KW - CHILDREN -- Hospital care
KW - CHILDREN -- United States
KW - CHILD health services
N1 - Accession Number: 13165257; Miller, Marlene R. 1; Email Address: mmille21@jhmi.edu Zhan, Chunliu 2; Affiliation: 1: Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 2: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, Maryland.; Source Info: Jun2004, Vol. 113 Issue 6, p1741; Subject Term: CHILDREN'S hospitals; Subject Term: PEDIATRICS; Subject Term: CHILDREN -- Hospital care; Subject Term: CHILDREN -- United States; Subject Term: CHILD health services; NAICS/Industry Codes: 622112 Paediatric hospitals; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Michaud, Linda J.
AU - Sandler, Adrian D.
AU - Cartwright, J. Daniel
AU - Duby, John C.
AU - Johnson, Chris Plauch
AU - Kaplan, Lawrence C.
AU - Levey, Eric B.
AU - Murphy, Nancy A.
AU - Tilton, Ann Henderson
AU - Crider, Bev
AU - McPherson, Merle
AU - Yeargin-Allsopp, Marshalyn
AU - Mucha, Stephanie
T1 - Prescribing Therapy Services for Children With Motor Disabilities.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/06//
VL - 113
IS - 6
M3 - Article
SP - 1836
EP - 1838
PB - American Academy of Pediatrics
SN - 00314005
AB - Pediatricians often are called on to pre-scribe physical, occupational, and speech-language ther-apy services for children with motor disabilities. This report defines the context in which rehabilitation thera-pies should be prescribed, emphasizing the evaluation and enhancement of the child's function and abilities and participation in age-appropriate life roles. The report encourages pediatricians to work with teams including the parents, child, teachers, therapists, and other physi-cians to ensure that their patients receive appropriate therapy services. Pediatrics 2004;113:1836 --1838; children with motor disabilities, physical therapy, occupational therapy, speech-language therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSICAL therapy for children
KW - OCCUPATIONAL therapy for children
KW - MOTOR ability in children
KW - DISABILITIES
KW - PHYSICAL therapy
N1 - Accession Number: 13164779; Michaud, Linda J. 1 Sandler, Adrian D. Cartwright, J. Daniel Duby, John C. Johnson, Chris Plauch Kaplan, Lawrence C. Levey, Eric B. Murphy, Nancy A. Tilton, Ann Henderson Crider, Bev McPherson, Merle 2 Yeargin-Allsopp, Marshalyn 3 Mucha, Stephanie; Affiliation: 1: American Academy of Physical Medicine and Rehabilitation 2: Maternal and Child Health Bureau 3: Centers for Disease Control and Prevention; Source Info: Jun2004, Vol. 113 Issue 6, p1836; Subject Term: PHYSICAL therapy for children; Subject Term: OCCUPATIONAL therapy for children; Subject Term: MOTOR ability in children; Subject Term: DISABILITIES; Subject Term: PHYSICAL therapy; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gaughan, Denise M.
AU - Hughes, Michael D.
AU - Oleske, James M.
AU - Malee, Kathleen
AU - Gore, Carol A.
AU - Nachman, Sharon
T1 - Psychiatric Hospitalizations Among Children and Youths With Human Immunodeficiency Virus Infection.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/06//
VL - 113
IS - 6
M3 - Article
SP - e544
EP - e551
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. Psychiatric manifestations of pediatric human immunodeficiency virus (HIV) infec-tion have been described. However, data on severe se-quelae requiring hospitalization among this population have not been reported. Methods. The Pediatric Acquired Immunodeficiency Syndrome (AIDS) Clinical Trials Group (PACTG) 219C is a prospective cohort study designed to examine long-term outcomes among HIV-infected children and HIV-uninfected infants born to HIV-infected women. Chil-dren with HIV infection who have enrolled in PACTG 219C are examined quarterly, with collection of clinical and laboratory data. Hospitalizations and diagnoses for all participants between September 2000 (when enroll-ment into PACTG 219C was started) and December 2002 were reviewed. Results. Among 1808 HIV-infected participants who were <15 years of age at the last visit date, 25 children had been hospitalized for psychiatric manifestations, 8 before enrollment into PACTG 219C. Seventeen children were hospitalized during 2757 person-years of follow-up monitoring after entry into PACTG 219C, which repre-sents an incidence of 6.17 cases per 1000 person-years (95% confidence interval: 3.59 --9.87 cases per 1000 person-years). This was significantly higher than the incidence of 1.70 cases per 1000 person-years (95% confidence in-terval: 1.67--1.72 cases per 1000 person-years) in the gen-eral pediatric population <15 years of age, as reported in the 2000 National Hospital Discharge Survey, yielding a relative rate of 3.62 (95% confidence interval: 2.11--5.80). A total of 32 HIV-infected children, regardless of age, were hospitalized because of psychiatric illnesses. The major-ity of patients were admitted because of depression (n = 16) or behavioral disorders (n = 8). Fifteen (47%) under-went multiple psychiatric hospitalizations. The median age at the first psychiatric hospitalization was 11 years (range: 4--17 years); all patients had been... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHIATRIC hospital care
KW - CHILDREN -- Hospital care
KW - HIV infections
KW - CHILD psychology
KW - AIDS (Disease)
N1 - Accession Number: 13164639; Gaughan, Denise M. 1,2 Hughes, Michael D. 2 Oleske, James M. 3 Malee, Kathleen 4 Gore, Carol A. 5 Nachman, Sharon 6; Email Address: sharon.nachman@stonybrook.edu; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 2: Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 3: Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 4: Departments of Infectious Diseases and Child and Adolescent Psychiatry, Children's Memorial Hospital, Chicago, Illinois 5: Community Constituency Group, Conroe, Texas 6: Department of Pediatric Infectious Disease, State University of New York, Health Science Center, Stony Brook, New York.; Source Info: Jun2004, Vol. 113 Issue 6, pe544; Subject Term: PSYCHIATRIC hospital care; Subject Term: CHILDREN -- Hospital care; Subject Term: HIV infections; Subject Term: CHILD psychology; Subject Term: AIDS (Disease); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Griffin, Marie R.
AU - Stein, C. Michael
AU - Graham, David J.
AU - Daugherty, James R.
AU - Arbogast, Patrick G.
AU - Ray, Wayne A.
T1 - High frequency of use of rofecoxib at greater than recommended doses: cause for concern.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2004/06//
VL - 13
IS - 6
M3 - Article
SP - 339
EP - 343
SN - 10538569
AB - Purpose To determine the prevalence of chronic use of rofecoxib 50 mg. Rofecoxib is unusual among nonsteroidal anti-inflammatory drugs (NSAIDs) in that the licensed dose for acute pain is double the maximum dose recommended for chronic use. The 50 mg dose is recommended for acute pain only, for a maximum of 5 days. In clinical trials of chronic use for arthritis, hypertension was more frequent in patients assigned 50 mg rofecoxib than in those assigned lower doses or other NSAIDs. Thus chronic use of high doses of rofecoxib has implications for patient safety. Methods Cross-sectional analysis of the prevalence of chronic use of rofecoxib 50 mg in 2001, among persons aged ≥50 years, enrolled in the Tennessee Medicaid program. Results On 1 July 2001, 14% of the study population had a current prescription for an NSAID, with a supply of pills for >5 days. Of all NSAID prescriptions, 25% were for rofecoxib, and 17% of these prescriptions were for >25 mg daily. Of those prescribed >25 mg daily, 71% filled prescriptions for at least 50 mg for 30 days. In this latter group, 60% and 69% filled another rofecoxib prescription within 1 and 2 weeks, respectively, of the end of their 30 days supply. Demographics and co-morbid conditions of high dose rofecoxib users did not differ substantially from users of other NSAIDs or the total population. Conclusion Use of rofecoxib 50 mg for >5 days is relatively common. In view of dose-related adverse effects, such use should be discouraged. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709973; Griffin, Marie R. 1,2,3,4; Stein, C. Michael 2,3; Graham, David J. 5; Daugherty, James R. 1; Arbogast, Patrick G. 1,3; Ray, Wayne A. 1,3,4; Affiliations: 1: Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; 2: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; 3: Vanderbilt Center for Education and Research on Therapeutics, Nashville, TN, USA; 4: Geriatric Research Education and Clinical Center, Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA; 5: Food and Drug Administration, TN, USA; Issue Info: Jun2004, Vol. 13 Issue 6, p339; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.879
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brown, A. E.
AU - Sadler, K. E.
AU - Tomkins, S. E.
AU - McGarrigle, C. A.
AU - LaMontagne, D. S.
AU - Goldberg, D.
AU - Tookey, P. A.
AU - Smyth, B.
AU - Thomas, D.
AU - Murphy, G.
AU - Parry, J. V.
AU - Evans, B. G.
AU - Gill, O. N.
AU - Ncube, F.
AU - Fenton, K. A.
T1 - Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2004/06//
VL - 80
IS - 3
M3 - Article
SP - 159
EP - 166
SN - 13684973
AB - Sexual health in the United Kingdom has deteriorated in recent years with further increases in HIV and other sexually transmitted infections (STIs) reported in 2002. This paper describes results from the available surveillance data in the United Kingdom from the Health Protection Agency and its national collaborators. The data sources range from voluntary reports of HIV/AIDS from clinicians, CD4 cell count monitoring, a national census of individuals living with HIV, and the Unlinked Anonymous Programme, to statutory reports of STIs from genitourinary medicine (GUM) clinics and enhanced STI surveillance systems. In 2002, an estimated 49 500 adults aged over 15 years were living with HIV in the United Kingdom, of whom 31% were unaware of their infection. Diagnoses of new HIV infections have doubled from 1997 to 2002, mainly driven by heterosexuals who acquired their infection abroad. HIV transmission also continues within the United Kingdom, particularly among homo/bisexual men who, in 2002, accounted for 80% of all newly diagnosed HIV infections acquired in the United Kingdom. New diagnoses of syphilis have increased eightfold, and diagnoses of chlamydia and gonorrhoea have doubled from 1997 to 2002 overall; STI rates disproportionately affect homo/bisexual men and young people. Effective surveillance is essential in the provision of timely information on the changing epidemiology of HIV and other STIs; this information is necessary for the targeting of prevention efforts and through providing baseline information against which progress towards targets can be monitored. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Infections is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - MEDICAL personnel
KW - PUBLIC health
KW - HEALTH surveys
KW - CHLAMYDIA
KW - GENITOURINARY organs
N1 - Accession Number: 13527733; Brown, A. E. 1; Email Address: brown@hpa.org.uk Sadler, K. E. 1 Tomkins, S. E. 1 McGarrigle, C. A. 1 LaMontagne, D. S. 1 Goldberg, D. 2 Tookey, P. A. 3 Smyth, B. 4 Thomas, D. 5 Murphy, G. 6 Parry, J. V. 6 Evans, B. G. 1 Gill, O. N. 1 Ncube, F. 1 Fenton, K. A. 7; Affiliation: 1: HIV and STI Department, Health Protection Agency, Communicable Disease Surveillance Centre, UK. 2: Scottish Centre for Infection and Environmental Health, UK. 3: Institute of Child Health (ICH), University College London, UK. 4: Health Protection Agency, Communicable Disease Surveillance Centre (Northern Ireland), UK. 5: National Public Health Service for Wales, Communicable Disease Surveillance Centre, UK. 6: Sexually Transmitted and Blood Borne Viruses Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, UK. 7: Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK.; Source Info: Jun2004, Vol. 80 Issue 3, p159; Subject Term: HIV infections; Subject Term: MEDICAL personnel; Subject Term: PUBLIC health; Subject Term: HEALTH surveys; Subject Term: CHLAMYDIA; Subject Term: GENITOURINARY organs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1136/sti.2003.009571
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13527733&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Hubbs, Ann F.
AU - Mercer, Robert
AU - Robinson, Victor A.
AU - Ramsey, Dawn
AU - McLaurin, Jeff
AU - Khan, Amir
AU - Battelli, Lori
AU - Brumbaugh, Kurt
AU - Teass, Alexander
AU - Castranova, Vincent
T1 - Progression of Lung Inflammation and Damage in Rats After Cessation of Silica Inhalation.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/06//
VL - 79
IS - 2
M3 - Article
SP - 370
EP - 380
PB - Oxford University Press / USA
SN - 10966080
AB - Human epidemiologic studies have found that silicosis may develop or progress even after occupational exposure has ended, suggesting that there is a threshold lung burden above which silica-induced pulmonary disease progresses without further exposure. We previously described the time course of rat pulmonary responses to silica inhalation as biphasic, the initial phase characterized by increased but controlled pulmonary inflammation and damage. However, after a threshold lung burden was exceeded, rapid progression of silica-induced pulmonary disease occurred. To test the hypothesis that there is a threshold lung burden above which silica-induced pulmonary disease progresses without further exposure we initiated a study to investigate the relationship between silica exposure, the initiation and progression of silica-induced pulmonary disease, and recovery. Rats were exposed to silica (15 mg/m3, 6 h/day) for either 20, 40, or 60 days. A portion of the rats from each exposure were maintained without further exposure for 36 days to examine recovery. The major findings of this study are: (1) silica-exposed rats were not in pulmonary overload, and lung silica burden decreased with recovery; (2) pulmonary inflammation, damage and lipidosis increased with recovery for rats exposed to silica for 40 and 60 days, but not 20 days; (3) histopathology revealed changes in silica-induced alveolitis, epithelial hypertrophy and hyperplasia, and alveolar lipoproteinosis consistent with bronchoalveolar lavage (BAL) endpoints; and (4) pulmonary fibrosis developed even when exposure was stopped prior to its initial development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Threshold limit values (Industrial toxicology)
KW - Silicon compounds
KW - Lung diseases
KW - Silicosis -- Risk factors
KW - Rats
KW - Pulmonary fibrosis
KW - Inflammation
KW - pulmonary inflammation
KW - recovery
KW - silica inhalation
KW - silica lung burden
N1 - Accession Number: 20620234; Porter, Dale W. 1; Email Address: DPorter@cdc.gov; Hubbs, Ann F. 1; Mercer, Robert 1; Robinson, Victor A. 1; Ramsey, Dawn 2; McLaurin, Jeff 2; Khan, Amir 2; Battelli, Lori 1; Brumbaugh, Kurt 1; Teass, Alexander 2; Castranova, Vincent 1; Affiliations: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505; 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio 45226; Issue Info: Jun2004, Vol. 79 Issue 2, p370; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Silicon compounds; Subject Term: Lung diseases; Subject Term: Silicosis -- Risk factors; Subject Term: Rats; Subject Term: Pulmonary fibrosis; Subject Term: Inflammation; Author-Supplied Keyword: pulmonary inflammation; Author-Supplied Keyword: recovery; Author-Supplied Keyword: silica inhalation; Author-Supplied Keyword: silica lung burden; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1093/toxsci/kfh110
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hutter, Joseph C.
AU - Luu, Hoan M. Y.
AU - Kim, Chung S.
T1 - A dynamic simulation of bisphenol A dosimetry in neuroendocrine organs.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2004/06//
VL - 20
IS - 1-5
M3 - Article
SP - 29
EP - 40
PB - Sage Publications, Ltd.
SN - 07482337
AB - Bisphenol A (BPA) is a known xenoestrogen with similar properties to 17β-estradiol. BPA and estrogen are hydrophobic compounds, and this affects the pharmacokinetics of both compounds in mammals. In a previous study we measured the distribution of BPA in female F344 rats exposed to oral doses of 0.1, 10 and 100 mg/kg. The results showed distribution to target neuroendocrine organs at all doses tested. Using these results, we developed a pharmacokinetic model to predict the dynamic uptake and excretion of BPA by various routes of exposure (po, iv, sc, ip). The model was able to simulate the entire time course (48 h) following various routes of exposure in rats over the dose ranges tested. The model indicated that the ultimate tissue uptake of BPA was established by the rapid initial transfer of free BPA into tissues. After free BPA enters the systemic circulation, metabolism and excretion reactions cause a relatively short duration and rapid decline. This period is followed by a slower long-term decline characteristic of BPA's biphasic pharmacokinetics. Plasma protein and tissue binding reactions established the long-term half-life of BPA in the body. Route differences in tissue uptake were directly related to the competition between transfer and binding reactions during the absorption phase. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARANEURONS
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
KW - PHARMACOLOGY
KW - MICE as laboratory animals
KW - ESTROGEN
KW - bisphenol A
KW - neuroendocrine organs
KW - PHARMACOKINETIC MODELLING
N1 - Accession Number: 16382550; Hutter, Joseph C. 1; Email Address: jch@cdrh.fda.gov Luu, Hoan M. Y. 1 Kim, Chung S. 2; Affiliation: 1: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA 2: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, USA; Source Info: 2004, Vol. 20 Issue 1-5, p29; Subject Term: PARANEURONS; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Subject Term: PHARMACOLOGY; Subject Term: MICE as laboratory animals; Subject Term: ESTROGEN; Author-Supplied Keyword: bisphenol A; Author-Supplied Keyword: neuroendocrine organs; Author-Supplied Keyword: PHARMACOKINETIC MODELLING; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
L3 - 10.1191/0748233704th187oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16382550&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, CS
AU - Sapienza, PP
AU - Ross, IA
AU - Johnson, W
AU - Luu, HMD
AU - Hutter, JC
T1 - Distribution of bisphenol A in the neuroendocrine organs of female rats.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2004/06//
VL - 20
IS - 1-5
M3 - Article
SP - 41
EP - 50
PB - Sage Publications, Ltd.
SN - 07482337
AB - The distribution of 14C-bisphenol A (BPA) in plasma and neuroendocrine organs was determined in Fischer 344 female rats following three oral doses (0.1, 10 or 100 mg/kg). Plasma and tissue maximum concentrations (Cmax) were reached within 15–30 min of dosing. Plasma areas-under-thecurve (AUC) ranged from 0.06 to 53.9 m g-h/mL. The AUCs of the pituitary gland and uterus/gonads were 16–21% higher than that of plasma. The AUCs of hypothalamus and the rest of the brain were 43.7% and 77% of the plasma AUCs, respectively. In the brain tissue, the exposure increased linearly with the oral dose, as the dose was increased from 0.1 to 10 and 100 mg/kg; the exposure in the brain relative to the plasma increased by factors of 1, 1.19 and 1.24. This indicates that the brain barrier systems do not limit the access of the lipophilic BPA to the brain. The increases of the uterus/gonads relative to the plasma were 1, 1.07 and 1.04. Tissue partitioning was also examined in vitro by the uptake of 14C-BPA. The BPA tissue/blood partition coefficients were as follows: heart, 7.5; liver, 6.1; kidney, 6.4; fat, 3.6; muscle, 2.6; breast, 3.6; ovaries, 9.1; uterus, 5.9; stomach, 5.1; and small intestine, 6.7. The tissue/cerebrospinal fluid partition coefficients were as follows: pituitary gland, 12.8; brain stem, 6.1; cerebellum, 6.4; hippocampus, 7.1; hypothalamus, 6.1; frontal cortex, 4.9; and caudate nucleus, 6.8. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARANEURONS
KW - MICE as laboratory animals
KW - HIPPOCAMPUS (Brain)
KW - CEREBRAL cortex
KW - BRAIN
KW - BLOOD plasma
KW - bisphenol A
KW - neuroendocrine organs
KW - PHARMACOKINETICS
N1 - Accession Number: 16382549; Kim, CS 1; Email Address: csk@cfsan.fda.gov Sapienza, PP 1 Ross, IA 1 Johnson, W 1 Luu, HMD 2 Hutter, JC 2; Affiliation: 1: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, USA 2: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Rock ville, USA; Source Info: 2004, Vol. 20 Issue 1-5, p41; Subject Term: PARANEURONS; Subject Term: MICE as laboratory animals; Subject Term: HIPPOCAMPUS (Brain); Subject Term: CEREBRAL cortex; Subject Term: BRAIN; Subject Term: BLOOD plasma; Author-Supplied Keyword: bisphenol A; Author-Supplied Keyword: neuroendocrine organs; Author-Supplied Keyword: PHARMACOKINETICS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1191/0748233704th186oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16382549&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holovac, Mary Ann
T1 - A balancing act in the United States Drug Industry: pioneer and generic drugs, the Orange Book, marketing protection and the US consumer
JO - World Patent Information
JF - World Patent Information
Y1 - 2004/06//
VL - 26
IS - 2
M3 - Article
SP - 123
SN - 01722190
AB - This article reviews the range of laws and requirements that surround the creation, testing and marketing of pharmaceutical materials in the USA. It focuses in particular on the Orange Book––more formally Approved Drug Products with Therapeutic Equivalence Evaluations––and its role in the process of providing safe and effective drugs at reasonable cost for the consumer, while ensuring that the corresponding research and development in creating new drug products is rewarded. Specific topics covered include: the history and purpose of the `Orange Book'', the legislative background, safety and effectiveness, therapeutic equivalence, Waxman-Hatch legislation, the patent position, various forms of exclusivity of marketing rights––such as orphan, Waxman-Hatch, and pediatric, and patent certification as part of an abbreviated new drug application. [Copyright &y& Elsevier]
AB - Copyright of World Patent Information is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - GENERIC drugs
KW - CONSUMERS -- United States
KW - UNITED States
KW - Bioequivalence
KW - Drug effectiveness
KW - Drug safety
KW - Generic drug
KW - Grandfather drug
KW - Kefauver-Harris
KW - Marketing exclusivity
KW - NDA
KW - New drug application
KW - Orange Book
KW - Orphan drug
KW - Patent certification
KW - Patent protection
KW - Pediatric drug
KW - Pharmaceutical products
KW - Therapeutic equivalence
KW - Waxman-Hatch
N1 - Accession Number: 12906486; Holovac, Mary Ann 1; Email Address: holovacm@cder.fda.gov; Affiliation: 1: Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Jun2004, Vol. 26 Issue 2, p123; Subject Term: PHARMACEUTICAL industry; Subject Term: GENERIC drugs; Subject Term: CONSUMERS -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Bioequivalence; Author-Supplied Keyword: Drug effectiveness; Author-Supplied Keyword: Drug safety; Author-Supplied Keyword: Generic drug; Author-Supplied Keyword: Grandfather drug; Author-Supplied Keyword: Kefauver-Harris; Author-Supplied Keyword: Marketing exclusivity; Author-Supplied Keyword: NDA; Author-Supplied Keyword: New drug application; Author-Supplied Keyword: Orange Book; Author-Supplied Keyword: Orphan drug; Author-Supplied Keyword: Patent certification; Author-Supplied Keyword: Patent protection; Author-Supplied Keyword: Pediatric drug; Author-Supplied Keyword: Pharmaceutical products; Author-Supplied Keyword: Therapeutic equivalence; Author-Supplied Keyword: Waxman-Hatch; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.wpi.2003.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=12906486&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-13222-006
AN - 2004-13222-006
AU - Kaftarian, Shakeh
AU - Robinson, Elizabeth
AU - Compton, Wilson
AU - Davis, Beverly Watts
AU - Volkow, Nora
T1 - Erratum.
JF - Prevention Science
JO - Prevention Science
JA - Prev Sci
Y1 - 2004/06//
VL - 5
IS - 2
SP - 135
EP - 135
CY - Germany
PB - Springer
SN - 1389-4986
SN - 1573-6695
AD - Kaftarian, Shakeh, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD, US, 20892-9589
N1 - Accession Number: 2004-13222-006. Partial author list: First Author & Affiliation: Kaftarian, Shakeh; National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, US. Release Date: 20040517. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Drug Abuse Prevention; Program Development; Schools. Classification: Drug & Alcohol Rehabilitation (3383); Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Page Count: 1. Issue Publication Date: Jun, 2004.
AB - Reports an error in the original article by Kaftarian et al (Prevention Science, 2004[March], Vol 5(1), 1-3). The name of the author Elizabeth Robertson was incorrectly printed as Elizaqbeth Robinson. (The following abstract of this article originally appeared in record [rid]2004-10917-001[/rid].) Drug abuse often starts during childhood and adolescence; therefore, prevention strategies need to target these early stages of development. Increasing demands on schools to focus their efforts on the 'basics' has led to what is perceived to be decreased access to schools for prevention research and to diminished interest by schools in investing time and money in science-based prevention interventions. This special issue includes a total of eight articles, six of which grew out of presentations from the meeting. The remaining two were included here because of their direct relevance to the theme of the conference. This introduction provides an overview of all eight articles as well as the suggestions developed in the interactive discussion sessions. In general the articles explore three main themes: (1) the necessity for innovative research designs and methodologies which could have direct bearing on the value and applicability of research-based programs in practice; (2) the importance of... (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention research
KW - prevention strategies
KW - drug abuse
KW - schools
KW - 2004
KW - Drug Abuse Prevention
KW - Program Development
KW - Schools
KW - 2004
DO - 10.1023/B:PREV.0000023170.81886.1f
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-13222-006&site=ehost-live&scope=site
UR - jkaftari@nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15880-005
AN - 2004-15880-005
AU - Ashman, Jill J.
AU - Pérez-Jiménez, David
AU - Marconi, Katherine
T1 - Health and Support Service Utilization Patterns of American Indians and Alaska Natives Diagnosed with HIV/AIDS.
JF - AIDS Education and Prevention
JO - AIDS Education and Prevention
Y1 - 2004/06//
VL - 16
IS - 3
SP - 238
EP - 249
CY - US
PB - Guilford Publications
SN - 0899-9546
AD - Ashman, Jill J., Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 7-90, Rockville, MD, US, 20857
N1 - Accession Number: 2004-15880-005. PMID: 15237053 Partial author list: First Author & Affiliation: Ashman, Jill J.; Health Resources and Services Administration, Rockville, MD, US. Release Date: 20040726. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Alaska Natives; American Indians; Health Care Services; Health Care Utilization. Minor Descriptor: Demographic Characteristics; Health; Treatment Outcomes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jun, 2004.
AB - The purpose of this analysis is twofold: to examine the types of health and support services provided by CARE Act funded providers to American Indians/ Alaska Natives and to compare the characteristics and service utilization patterns for this group with those of individuals from other racial/ethnic groups. We present an analysis of the demographic characteristics, service utilization, and health outcomes of all HIV-infected clients who received services in five geographic areas at agencies that were funded through the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act. Standard chi-square tests were used to test for statistically significant differences (p < .05) between the demographic characteristics and service utilization patterns of matched pairs of HIV-positive American Indian/Native Alaskans with HIV-positive individuals of other racial and ethnic backgrounds. Individuals were matched on gender, age, insurance, AIDS diagnosis, and site. Other data examined include client characteristics (income, homelessness, HIV exposure category, and source of health care), health indicators (CDC-defined disease stage, CD4+ counts, substance abuse and psychiatric illness) and service utilization (medical care; mental health treatment/counseling; substance abuse treatment/counseling; case management; dental care; housing, food, emergency financial, and transportation assistance, and buddy/companion and client advocacy services). There were no statistically significant differences between the two groups for HIV exposure category, CD4 count, substance abuse problem, and being homeless and in their likelihood to receive medical care, mental health or substance abuse treatment/counseling, dental care, food, emergency financial, and transportation assistance, as well as buddy/companion and client advocacy services. They were more likely (55% vs. 46%) to receive case management services than the matched individuals from other racial/ethnic groups. They were also more likely to receive housing assistance (35% vs. 25%). The analysis provides evidence that when individuals are matched on key demographic and health characteristics, few differences remain between HIV-positive American Indians/Native Alaskans and other racial/ethnic groups. The two exceptions are case management and housing assistance. The significantly higher use of case management is not surprising, given the emphasis by American Indians/ Alaska Natives on traditional Native American case management. In contrast, the significantly higher use of housing assistance by American Indians/Alaska Natives was unexpected. Exploring the potential need for housing assistance among all American Indians/Alaska Natives served by the Ryan White CARE Act needs to be considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service utilization pattern
KW - health service
KW - American Indians
KW - Alaska Natives
KW - AIDS patients
KW - demographic characteristics
KW - health outcomes
KW - 2004
KW - AIDS
KW - Alaska Natives
KW - American Indians
KW - Health Care Services
KW - Health Care Utilization
KW - Demographic Characteristics
KW - Health
KW - Treatment Outcomes
KW - 2004
DO - 10.1521/aeap.16.3.238.35437
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15880-005&site=ehost-live&scope=site
UR - JAshman@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-15815-014
AN - 2004-15815-014
AU - Middelkoop, Barend J. C.
AU - van der Wal, Gerrit
T1 - Culture-specific diabetes care for Surinam South Asians with a low socio-economic position: Who benefits?
T3 - Diabetes Mellitus
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 2004/06//
VL - 53
IS - 3
SP - 353
EP - 358
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
AD - Middelkoop, Barend J. C., Department of Epidemiology, Public Health Service (GGD), P.O. Box 12 652, 2500 DP, Hague, Netherlands
N1 - Accession Number: 2004-15815-014. PMID: 15186874 Partial author list: First Author & Affiliation: Middelkoop, Barend J. C.; Department of Epidemiology, Public Health Service (GGD), Hague, Netherlands. Release Date: 20050131. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blood Sugar; Client Characteristics; Diabetes; Intervention; Socioeconomic Status. Minor Descriptor: South Asian Cultural Groups. Classification: Health Psychology & Medicine (3360). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2004.
AB - The South Asians in The Netherlands have a high diabetes prevalence in combination with a low socio-economic position. A new, culture-specific type of care was developed. This intervention study investigates which patient characteristics are associated with success and whether those in the lowest socio-economic position have been reached. Before and after the end of the intensive guidance, the HbA1c of the patients (n=101) was measured. The following variables were significantly related to success (defined as a decrease in HbA1c ≥ 0.8%): a high initial HbA1c, a low BMI and presence of complications. The average improvement in HbA1c was significant only in the group with a higher socio-economic position. Although the patients with the lowest socio-economic position did not sufficiently benefit from this intervention, an overall improvement was achieved in this poorly educated study population. The further improvements in the care after the completion of this study should be evaluated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Surinam South Asians
KW - low socio-economic status
KW - patient characteristics
KW - culture-specific diabetes care
KW - intervention
KW - blood sugar
KW - 2004
KW - Blood Sugar
KW - Client Characteristics
KW - Diabetes
KW - Intervention
KW - Socioeconomic Status
KW - South Asian Cultural Groups
KW - 2004
DO - 10.1016/j.pec.2003.03.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-15815-014&site=ehost-live&scope=site
UR - b.j.c.middelkoop@ocw.denhaag.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-16094-015
AN - 2004-16094-015
AU - Mays, Glen P.
AU - Hesketh, Heather A.
AU - Ammerman, Alice S.
AU - Stockmyer, Chris K.
AU - Johnson, Tamara Lewis
AU - Bayne-Smith, Marcia
T1 - Integrating Preventive Health Services within Community Health Centers: Lessons from WISEWOMAN.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2004/06//
VL - 13
IS - 5
SP - 607
EP - 615
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Hesketh, Heather A., Mathematica Policy Research, Inc., 600 Maryland Avenue, S.W., Suite 550, Washington, DC, US, 20024
N1 - Accession Number: 2004-16094-015. PMID: 15257852 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Mays, Glen P.; Mathematica Policy Research, Inc., Washington, DC, US. Release Date: 20041206. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Human Females; Lifestyle; Risk Factors; Screening. Minor Descriptor: Cardiovascular Disorders; Community Services; Community Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jun, 2004.
AB - Background: Well-Integrated Screening and Evaluation for Women Across the Nation (WISEWOMAN) provides low-income, underserved women ages 40-64 with risk factor screening and lifestyle intervention and referral services to prevent cardiovascular disease (CVD). Integrating WISEWOMAN's services with the culturally appropriate medical care and support services offered by community health centers may improve the program's ability to reduce CVD burden among underserved women. Methods: We conducted a formative assessment of the perceived opportunities, challenges, and strategies associated with integrating WISEWOMAN into community health center settings. A panel of stakeholders that included health center and WISEWOMAN representatives was convened in 2002, and a semistructured discussion guide was used to elicit perspectives about integration. We also conducted an in-depth review of WISEWOMAN's history of collaboration with health centers in North Carolina. Results: Stakeholders perceived a clear need for integrating WISEWOMAN within health center settings, indicating that centers have few other resources to expand preventive services delivery and offer effective lifestyle interventions for underserved populations. Perceived barriers to integration included competing demands on health center resources, difficulties hiring staff for new programs, and administrative burdens associated with data collection and reporting. Experiences within North Carolina's WISEWOMAN project demonstrate, however, that lifestyle interventions can be designed in ways that facilitate integration by health centers. Conclusions: Integration strategies need to be tailored to the resources, skills, and capacities available within health centers. As health centers and WISEWOMAN projects gain more experience in collaborating, additional research should be conducted to identify how best to achieve integration within specific institutional and community contexts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventive health services
KW - community health centers
KW - Well-Integrated Screening and Evaluation for Women Across the Nation
KW - risk factor screening
KW - cardiovascular disease
KW - lifestyle intervention
KW - 2004
KW - Health Care Services
KW - Human Females
KW - Lifestyle
KW - Risk Factors
KW - Screening
KW - Cardiovascular Disorders
KW - Community Services
KW - Community Health
KW - 2004
DO - 10.1089/1540999041281070
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16094-015&site=ehost-live&scope=site
UR - hhesketh@mathematica-mpr.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-14927-006
AN - 2004-14927-006
AU - Herbeck, Diane M.
AU - West, Joyce C.
AU - Ruditis, Ilze
AU - Duffy, Farifteh F.
AU - Fitek, Diana J.
AU - Bell, Carl C.
AU - Snowden, Lonnie R.
T1 - Variations in use of second-generation antipsychotic medication by race among adult psychiatric patients.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2004/06//
VL - 55
IS - 6
SP - 677
EP - 684
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - West, Joyce C., 1000 Wilson Boulevard, Suite 1825, Arlington, VA, US, 22209
N1 - Accession Number: 2004-14927-006. PMID: 15175466 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Herbeck, Diane M.; University of California, Integrated Substance Abuse Programs, Los Angeles, CA, US. Release Date: 20040823. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Mental Health Services; Neuroleptic Drugs; Psychiatric Patients; Racial and Ethnic Differences. Minor Descriptor: Blacks; Psychiatrists; Treatment Outcomes; Whites. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2004.
AB - Objective: This study examined variations in the use of second-generation antipsychotic medication among African-American and non-Hispanic white patients in a national sample of adults who were treated by psychiatrists. Methods: This study used data from studies of psychiatric patients and treatments that were conducted by the American Psychiatric Institute for Research and Education's (APIRE's) Practice Research Network (PRN). Psychiatrists provided detailed clinical data for 126 African-American patients and 574 white patients who were randomly selected and for whom antipsychotic medications were prescribed. The study assessed differences by race in the use of second-generation antipsychotic medication, adjusting for clinical, sociodemographic, and health-system characteristics, including patients' source of payment for treatment. Results: African-American patients were less likely than white patients to receive second-generation antipsychotic medications (49 percent compared with 66 percent). After the analysis statistically adjusted for clinical, sociodemographic, and health-system characteristics, African-American patients remained less likely than white patients to receive second-generation antipsychotics. Conclusions: Because African Americans tended to receive medications that are not first-line recommended treatments and that have a greater risk of producing tardive dyskinesia and extrapyramidal side effects, African Americans could be expected to suffer diminished clinical status. This disparity may also contribute to lower rates of adherence and to more frequent emergency department visits and psychiatric hospitalizations among African Americans. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - African-American patients
KW - antipsychotic medication
KW - psychiatric hospitalizations
KW - adult psychiatric patients
KW - race
KW - 2004
KW - Drug Therapy
KW - Mental Health Services
KW - Neuroleptic Drugs
KW - Psychiatric Patients
KW - Racial and Ethnic Differences
KW - Blacks
KW - Psychiatrists
KW - Treatment Outcomes
KW - Whites
KW - 2004
DO - 10.1176/appi.ps.55.6.677
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-14927-006&site=ehost-live&scope=site
UR - jwest@psych.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-14418-006
AN - 2004-14418-006
AU - Rawson, Richard A.
AU - Marinelli-Casey, Patricia
AU - Anglin, M. Douglas
AU - Dickow, Alice
AU - Frazier, Yvonne
AU - Gallagher, Cheryl
AU - Galloway, Gantt P.
AU - Herrell, James
AU - Huber, Alice
AU - McCann, Michael J.
AU - Obert, Jeanne
AU - Pennell, Susan
AU - Reiber, Chris
AU - Vandersloot, Denna
AU - Zweben, Joan
T1 - A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2004/06//
VL - 99
IS - 6
SP - 708
EP - 717
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Rawson, Richard A., UCLA Integrated Substance Abuse Programs, 1640 S. Sepulveda Blvd, Suite 200, Los Angeles, CA, US, 90025
N1 - Accession Number: 2004-14418-006. PMID: 15139869 Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Rawson, Richard A.; University of California, Integrated Substance Abuse Programs, Los Angeles, CA, US. Institutional Authors: Methamphetamine Treatment Project Corporate Authors. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20040816. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Biopsychosocial Approach; Drug Abuse; Drug Therapy; Methamphetamine. Minor Descriptor: Drug Rehabilitation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: methamphetamine-dependence checklist; Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Clinical Trial; Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jun, 2004.
AB - Aims The Center for Substance Abuse Treatment (CSAT) Methamphetamine Treatment Project (MTP) is the largest randomized clinical trial of treatments for methamphetamine (MA) dependence to date. The objective of the study was to compare the Matrix Model, a manualized treatment method, with treatment-as-usual (TAU) in eight community out-patient settings in the Western United States. Design Over an 18-month period between 1999 and 2001, 978 treatment-seeking, MA-dependent people were randomly assigned to receive either TAU at each site or a manualized 16-week treatment (Matrix Model). Setting The study was conducted as an eight-site out-patient trial, with six sites located in California and one each in Montana and Hawaii. Findings In the overall sample, and in the majority of sites, those who were assigned to Matrix treatment attended more clinical sessions, stayed in treatment longer, provided more MA-free urine samples during the treatment period and had longer periods of MA abstinence than those assigned to receive TAU. Measures of drug use and functioning collected at treatment discharge and 6 months post-admission indicate significant improvement by participants in all sites and conditions when compared to baseline levels, but the superiority of the Matrix approach did not persist at these two timepoints. Conclusions Study results demonstrate a significant initial step in documenting the efficacy of the Matrix approach. Although the superiority of the Matrix approach over TAU was not maintained at the post-treatment timepoints, the in-treatment benefit is an important demonstration of empirical support for this psychosocial treatment approach. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methamphetamine dependence
KW - treatment-as-usual
KW - psychosocial approach
KW - 2004
KW - Biopsychosocial Approach
KW - Drug Abuse
KW - Drug Therapy
KW - Methamphetamine
KW - Drug Rehabilitation
KW - 2004
DO - 10.1111/j.1360-0443.2004.00707.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-14418-006&site=ehost-live&scope=site
UR - matrixex@ucla.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-16875-019
AN - 2004-16875-019
AU - Koller, Elizabeth A.
AU - Weber, Jena
AU - Doraiswamy, P. Murali
AU - Schneider, Bruce S.
T1 - A Survey of Reports of Quetiapine-Associated Hyperglycemia and Diabetes Mellitus.
JF - The Journal of Clinical Psychiatry
JO - The Journal of Clinical Psychiatry
JA - J Clin Psychiatry
Y1 - 2004/06//
VL - 65
IS - 6
SP - 857
EP - 863
CY - US
PB - Physicians Postgraduate Press
SN - 0160-6689
AD - Schneider, Bruce S., American Association of Medical Colleges, 2450 N Street, NW, Washington, DC, US, 20037-1126
N1 - Accession Number: 2004-16875-019. PMID: 15291665 Other Journal Title: Diseases of the Nervous System. Partial author list: First Author & Affiliation: Koller, Elizabeth A.; Division of Metabolic and Endocrine Drug Products, Center for Drug Evaluation and Review, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20040830. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes Mellitus; Hyperglycemia; Patients; Quetiapine. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2004.
AB - Objective: To explore the clinical characteristics of hyperglycemia in patients treated with quetiapine. Method: A pharmacovigilance survey of spontaneously reported adverse events in quetiapinetreated patients was conducted using reports from the U.S. Food and Drug Administration MedWatch program (January 1, 1997, through July 31, 2002) end published cases using the search terms hyperglycemia, diabetes, acidosis, ketosis, and ketoacidosis. Results: We identified 46 reports of quetiapine- associated hyperglycemia or diabetes and 9 additional reports of acidosis that occurred in the absence of hyperglycemia and were excluded from the immediate analyses. Of the reports of quetiapine-associated hyperglycemia, 34 patients had newly diagnosed hyperglycemia, 8 had exacerbation of preexisting diabetes mellitus, and 4 could not be classified. The mean ± SD age was 35.3 ± 16.2 years (range, 5-76 years). New-onset patients (aged 31.2 ± 14.8 years) tended to be younger than those with preexisting diabetes (43.5 ± 16.4 years, p = .08). The overall male:female ratio was 1.9. Most cases appeared within 6 months of quetiapine initiation. The severity of cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma. There were 21 cases of ketoacidosis or ketosis. There were 11 deaths. Conclusion: Atypical antipsychotic use may unmask or precipitate hyperglycemia. Update: An additional 23 cases were identified since August 1, 2002, the end of the first survey, by extending the search through November 30, 2003, bringing the total to 69. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quetiapine
KW - hyperglycemia
KW - diabetes mellitus
KW - patients
KW - acidosis
KW - 2004
KW - Diabetes Mellitus
KW - Hyperglycemia
KW - Patients
KW - Quetiapine
KW - 2004
DO - 10.4088/JCP.v65n0619
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16875-019&site=ehost-live&scope=site
UR - bschneider@aamc.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19007-006
AN - 2004-19007-006
AU - Woo, Emily Jane
AU - Ball, Robert
AU - Bostrom, Ann
AU - Shadomy, Sean V.
AU - Ball, Leslie K.
AU - Evans, Geoffrey
AU - Braun, Miles
T1 - Vaccine Risk Perception Among Reporters of Autism After Vaccination: Vaccine Adverse Event Reporting System 1990-2001.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2004/06//
VL - 94
IS - 6
SP - 990
EP - 955
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Woo, Emily Jane, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD, US, 20852
N1 - Accession Number: 2004-19007-006. Partial author list: First Author & Affiliation: Woo, Emily Jane; Vaccine Safety Branch, Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, US. Release Date: 20041101. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Autism Spectrum Disorders; Immunization; Risk Perception. Classification: Promotion & Maintenance of Health & Wellness (3365); Developmental Disorders & Autism (3250). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Issue Publication Date: Jun, 2004.
AB - Objectives: We investigated vaccine risk perception among reporters of autism to the Vaccine Adverse Event Reporting System (VAERS). Methods: We conducted structured interviews with 124 parents who reported autism and related disorders to VAERS from 1990 to 2001 and compared results with those of a published survey of parents in the general population. Results: Respondents perceived vaccine-preventable diseases as less serious than did other pa rents. Only 15% of respondents deemed immunization extremely important for children's health; two thirds had withheld vaccines from their children. Conclusions: Views of parents who believe vaccines injured their children differ significantly from those of the general population regarding the benefits of immunization. Understanding the factors that shape this perspective can improve communication among vaccine providers, policymakers, and parents/patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vaccination
KW - risk perception
KW - autism
KW - 2004
KW - Autism Spectrum Disorders
KW - Immunization
KW - Risk Perception
KW - 2004
DO - 10.2105/AJPH.94.6.990
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19007-006&site=ehost-live&scope=site
UR - wooj@cber.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Yetley, Elizabeth A.
AU - Rader, Jeanne I.
T1 - Modeling the Level of Fortification and Post-Fortification Assessments: U.S. Experience.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2004/06/02/Jun2004 Supplement
VL - 62
IS - 6
M3 - Article
SP - S50
EP - S59
SN - 00296643
AB - Mandatory fortification of enriched cereal-grain products became effective in the United States on January 1, 1998. This fortification was undertaken to assist women of child-bearing age in increasing their intake of folic acid to reduce their risk of having a pregnancy affected by a neural tube birth defect. The process by which the Food and Drug Administration modeled the level of fortification with folic acid illustrates the complex issues and general principles that emerge when fortification of a nation's food supply is evaluated as a means of addressing a public health concern. The effectiveness of fortification for a target population and safety for the much larger general population impose conflicting challenges that must be considered concurrently when making decisions regarding fortification. Recent data show improved folate status and apparent decreases in risk of neural tube birth defects in the U.S. Much about the long-term effects of the fortification program remains unknown and careful monitoring over time will be necessary to ensure that the program functions as intended. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid in human nutrition
KW - VITAMIN B12
KW - CEREAL products
KW - NUTRITION in pregnancy
KW - NEURAL tube -- Abnormalities
KW - UNITED States
KW - folic acid
KW - fortification
KW - post-fortification assessments
KW - vitamin b12
N1 - Accession Number: 13656239; Yetley, Elizabeth A. 1 Rader, Jeanne I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Source Info: Jun2004 Supplement, Vol. 62 Issue 6, pS50; Subject Term: FOLIC acid in human nutrition; Subject Term: VITAMIN B12; Subject Term: CEREAL products; Subject Term: NUTRITION in pregnancy; Subject Term: NEURAL tube -- Abnormalities; Subject Term: UNITED States; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: fortification; Author-Supplied Keyword: post-fortification assessments; Author-Supplied Keyword: vitamin b12; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13656239&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kogan, Michael D.
AU - Schuster, Mark A.
AU - Yu, Stella M.
AU - Park, Christina H.
AU - Olson, Lynn M.
AU - Inkelas, Moira
AU - Bethell, Christina
AU - Chung, Paul J.
AU - Halfon, Neal
T1 - Routine Assessment of Family and Community Health Risks: Parent Views and What They Receive.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/06/02/Jun2004 Supplement
VL - 113
M3 - Article
SP - 1934
EP - 1943
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. To examine the prevalence of parent--provider discussions of family and community health risks during well-child visits and the gaps between which issues are discussed and which issues parents would like to discuss. Methods. Data came from the National Survey of Early Childhood Health, a nationally representative sample of parents of 2068 children aged 4 to 35 months. The outcome measures were 1) the reported discussions with pediatric clinicians about 7 family and community health risks and 2) whether the parent believes that pediatric clinicians should ask parents about each risk. Results. Most parents believe that pediatric providers should discuss topics such as smoking in the household, financial difficulties, and emotional support available to the parent. However, with the exception of "household smoking," fewer than half of parents have been asked about these topics by their child's clinician. Parents of black and Hispanic children were more likely than parents of white children to be asked about several of these issues, as were parents of the youngest children and those with publicly financed health insurance. The greatest gap between parents' views and their reports of discussion with the clinician occur for parents of white children and older children. Among parents who hold the view that a topic should be discussed, parents of white and older children are less likely than others to report discussing some or all family and community health risks. Conclusion. The low frequency of discussions for many topics indicates potential unmet need. More universal surveillance of parents with young children might ensure that needs are not missed, particularly given that strong majorities of parents view family and community topics, with the exception of community violence, as appropriate for discussion in clinic visits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY health services
KW - FAMILIES -- Health
KW - PUBLIC health
KW - HEALTH risk assessment
KW - PSYCHOSOCIAL factors
N1 - Accession Number: 13165608; Kogan, Michael D. 1; Email Address: mkogan@hrsa.gov Schuster, Mark A. 2,3,4 Yu, Stella M. 1 Park, Christina H. 5 Olson, Lynn M. 6 Inkelas, Moira 7 Bethell, Christina 8 Chung, Paul J. 2 Halfon, Neal 2,7; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: Department of Pediatrics, University of California, Los Angeles, Los Angeles, California 3: Department of Health Services, School of Public Health, University of California, Los Angeles, Los Angeles, California 4: RAND Corporation, Los Angeles, California 5: ANASYS, Inc. 6: American Academy of Pediatrics, Elk Grove Village, Illinois 7: Department of Community Health Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, California 8: Child and Adolescent Health Measurement Initiative, Kaiser NW Center for Health Research; Source Info: Jun2004 Supplement, Vol. 113, p1934; Subject Term: COMMUNITY health services; Subject Term: FAMILIES -- Health; Subject Term: PUBLIC health; Subject Term: HEALTH risk assessment; Subject Term: PSYCHOSOCIAL factors; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13165608&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106611877
T1 - Psychiatric hospitalizations among children and youths with human immunodeficiency virus infection.
AU - Gaughan DM
AU - Hughes MD
AU - Oleske JM
AU - Malee K
AU - Gore CA
AU - Nachman S
Y1 - 2004/06/02/Jun2004 Supplement
N1 - Accession Number: 106611877. Corporate Author: Pediatric AIDS Clinical Trials Group 219C Team. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Jun2004 Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Statistical and Data Management Center of the PACTG, under National Institute of Allergy and Infectious Diseases cooperative agreement AI 41110. NLM UID: 0376422.
KW - HIV Infections -- Psychosocial Factors
KW - Hospitalization
KW - Hospitals, Psychiatric
KW - Mental Disorders -- Epidemiology
KW - Adolescence
KW - Antiviral Agents -- Therapeutic Use
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Cox Proportional Hazards Model
KW - Female
KW - HIV Infections -- Drug Therapy
KW - Incidence
KW - Length of Stay
KW - Male
KW - Mental Disorders -- Etiology
KW - Poisson Distribution
KW - Prospective Studies
KW - Puerto Rico
KW - Relative Risk
KW - Funding Source
KW - Risk Factors
KW - United States
KW - Human
SP - e544
EP - 51
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: Psychiatric manifestations of pediatric human immunodeficiency virus (HIV) infection have been described. However, data on severe sequelae requiring hospitalization among this population have not been reported. METHODS: The Pediatric Acquired Immunodeficiency Syndrome (AIDS) Clinical Trials Group (PACTG) 219C is a prospective cohort study designed to examine long-term outcomes among HIV-infected children and HIV-uninfected infants born to HIV-infected women. Children with HIV infection who have enrolled in PACTG 219C are examined quarterly, with collection of clinical and laboratory data. Hospitalizations and diagnoses for all participants between September 2000 (when enrollment into PACTG 219C was started) and December 2002 were reviewed. RESULTS: Among 1808 HIV-infected participants who were <15 years of age at the last visit date, 25 children had been hospitalized for psychiatric manifestations, 8 before enrollment into PACTG 219C. Seventeen children were hospitalized during 2757 person-years of follow-up monitoring after entry into PACTG 219C, which represents an incidence of 6.17 cases per 1000 person-years (95% confidence interval: 3.59-9.87 cases per 1000 person-years). This was significantly higher than the incidence of 1.70 cases per 1000 person-years (95% confidence interval: 1.67-1.72 cases per 1000 person-years) in the general pediatric population <15 years of age, as reported in the 2000 National Hospital Discharge Survey, yielding a relative rate of 3.62 (95% confidence interval: 2.11-5.80). A total of 32 HIV-infected children, regardless of age, were hospitalized because of psychiatric illnesses. The majority of patients were admitted because of depression (n = 16) or behavioral disorders (n = 8). Fifteen (47%) underwent multiple psychiatric hospitalizations. The median age at the first psychiatric hospitalization was 11 years (range: 4-17 years); all patients had been perinatally infected. Knowledge of HIV seropositivity status and having experienced a significant life event were both significantly associated with an increased risk of psychiatric hospitalization (hazard ratios of 6.13 and 3.04, respectively). No psychiatric hospitalizations were observed among the 1021 HIV-uninfected members of the cohort. CONCLUSIONS: Children with HIV/AIDS are at increased risk for psychiatric hospitalizations during childhood and early adolescence, compared with the general pediatric population. Knowledge of HIV seropositivity status and recent significant life events were significantly associated with increased risks of admission in this population.
SN - 0031-4005
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV
U2 - PMID: 15173535.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106611877&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106611932
T1 - Routine assessment of family and community health risks: parent view and what they receive [corrected] [published erratum appears in PEDIATRICS 2005 Sep;116(3):802].
AU - Kogan MD
AU - Schuster MA
AU - Yu SM
AU - Park CH
AU - Olson LM
AU - Inkelas M
AU - Bethell C
AU - Chung PJ
AU - Halfon N
Y1 - 2004/06/03/2004 Jun Supplement
N1 - Accession Number: 106611932. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2004 Jun Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Gerber Foundation; American Academy of Pediatrics Friends of Children Fund; Maternal and Child Health Bureau in the Health Resources and Services Administration (5-U05MC-00010200); and Commonwealth Fund. NLM UID: 0376422.
KW - Attitude to Health
KW - Child Welfare
KW - Parents -- Psychosocial Factors
KW - Pediatricians
KW - Professional-Family Relations
KW - Adult
KW - Analysis of Variance
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child Care
KW - Child, Preschool
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Ethnic Groups
KW - Family Relations
KW - Female
KW - Health Behavior
KW - Infant
KW - Interviews
KW - Logistic Regression
KW - Multivariate Analysis
KW - Odds Ratio
KW - Quality of Health Care
KW - Random Sample
KW - Risk Assessment
KW - Risk Taking Behavior
KW - Socioeconomic Factors
KW - United States
KW - Funding Source
KW - Human
SP - 1934
EP - 1943
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 113
IS - 6 part 2
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To examine the prevalence of parent-provider discussions of family and community health risks during well-child visits and the gaps between which issues are discussed and which issues parents would like to discuss. METHODS: Data came from the National Survey of Early Childhood Health, a nationally representative sample of parents of 2068 children aged 4 to 35 months. The outcome measures were 1) the reported discussions with pediatric clinicians about 7 family and community health risks and 2) whether the parent believes that pediatric clinicians should ask parents about each risk. RESULTS: Most parents believe that pediatric providers should discuss topics such as smoking in the household, financial difficulties, and emotional support available to the parent. However, with the exception of 'household smoking,' fewer than half of parents have been asked about these topics by their child's clinician. Parents of black and Hispanic children were more likely than parents of white children to be asked about several of these issues, as were parents of the youngest children and those with publicly financed health insurance. The greatest gap between parents' views and their reports of discussion with the clinician occur for parents of white children and older children. Among parents who hold the view that a topic should be discussed, parents of white and older children are less likely than others to report discussing some or all family and community health risks. CONCLUSION: The low frequency of discussions for many topics indicates potential unmet need. More universal surveillance of parents with young children might ensure that needs are not missed, particularly given that strong majorities of parents view family and community topics, with the exception of community violence, as appropriate for discussion in clinic visits.
SN - 0031-4005
AD - Office of Data and Information Management, Maternal and Child Health Bureau, HRSA, 5600 Fishers La, Rm 18-41, Rockville, MD 20857; mkogan@hrsa.gov
U2 - PMID: 15173464.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kumar, Amit
AU - Vaid, Ankush
AU - Syin, Chaing
AU - Sharma, Pushkar
T1 - PfPKB, a Novel Protein Kinase B-like Enzyme from Plasmodium falciparum.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/06/04/
VL - 279
IS - 23
M3 - Article
SP - 24255
EP - 24264
SN - 00219258
AB - Extracellular signals control various important functions of a eukaryotic cell, which is often achieved by regulating a battery of protein kinases and phosphatases. Protein Kinase B (PKB) is an important member of the phosphatidylinositol 3-kinase-dependent signaling pathways in several eukaryotes, but the role of PKB in protozoan parasites is not known. We have identified a protein kinase B homologue in Plasmodium falciparum (PfPKB) that is expressed mainly in the schizonts and merozoites. Even though PfPKB shares high sequence homology with PKB catalytic domain, it lacks a pleckstrin homology domain typically found at the N terminus of the mammalian enzyme. Biochemical studies performed to understand the mechanism of PfPKB catalytic activation suggested (i) its activation is dependent on autophosphorylation of a serine residue (Ser-271) in its activation loop region and (ii) PfPKB has an unusual N-terminal region that was found to negatively regulate its catalytic activity. We also identified an inhibitor of PfPKB activity that also inhibits P. falciparum growth, suggesting that this enzyme may be important for the development of the parasite. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EUKARYOTIC cells
KW - PROTEIN kinases
KW - PHOSPHATASES
KW - PROTOZOA
KW - FUNGI -- Parasites
KW - PLASMODIUM falciparum
KW - MALARIA
N1 - Accession Number: 13884726; Kumar, Amit 1 Vaid, Ankush 1 Syin, Chaing 2 Sharma, Pushkar 1; Email Address: pushkar@nii.res.in; Affiliation: 1: Eukaryotic Gene Expression Laboratory, National Insitute of Immunology, New Delhi 110067, India 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852; Source Info: 6/4/2004, Vol. 279 Issue 23, p24255; Subject Term: EUKARYOTIC cells; Subject Term: PROTEIN kinases; Subject Term: PHOSPHATASES; Subject Term: PROTOZOA; Subject Term: FUNGI -- Parasites; Subject Term: PLASMODIUM falciparum; Subject Term: MALARIA; Number of Pages: 10p; Document Type: Article
L3 - 10.1074/jbc.M312855200
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Meehan, Patrick J.
AU - Rosenstein, Nancy E.
AU - Gillen, Matthew
AU - Meyer, Richard F.
AU - Kiefer, Max J.
AU - Deitchman, Scott
AU - Besser, Richard E.
AU - Ehrenberg, Richard L.
AU - Edwards, Kathleen M.
AU - Martinez, Kenneth F.
T1 - Responding to Detection of Aerosolized Bacillus anthracis by Autonomous Detection Systems in the Workplace.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/06/05/6/4/2004 Aerosolized Bacillus
VL - 53
IS - RR-7
M3 - Report
SP - 1
EP - 11
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Autonomous detection systems (ADSs) are under development to detect agents of biologic and chemical terror in the environment. These systems will eventually be able to detect biologic and chemical hazards reliably and provide approximate real-time alerts that an agent is present. One type of ADS that tests specifically for Bacillus anthracis is being deployed in hundreds of postal distribution centers across the United States. Identification of aerosolized B. anthracis spores in an air sample can facilitate prompt on-site decontamination of workers and subsequent administration of postexposure prophylaxis to prevent inhalational anthrax. Every employer who deploys an ADS should develop detailed plans for responding to a positive signal. Responding to ADS detection of B. anthracis involves coordinating responses with community partners and should include drills and exercises with these partners. This report provides guidelines in the following six areas: 1) response and consequence management planning, including the minimum components of a facility response plan; 2) immediate response and evacuation; 3) decontamination of potentially exposed workers to remove spores from clothing and skin and prevent introduction of B. anthracis into the worker's home and conveyances; 4) laboratory confirmation of an ADS signal; 5) steps for evaluating potentially contaminated environments; and 6) postexposure prophylaxis and follow-up. [ABSTRACT FROM AUTHOR]
AB - Copyright of MMWR: Morbidity & Mortality Weekly Report is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS anthracis
KW - BACILLUS (Bacteria)
KW - ANTHRAX
KW - INDUSTRIAL hygiene
KW - UNITED States
N1 - Accession Number: 13581657; Meehan, Patrick J. 1 Rosenstein, Nancy E. 2 Gillen, Matthew 3 Meyer, Richard F. 4 Kiefer, Max J. 3 Deitchman, Scott 1 Besser, Richard E. 2 Ehrenberg, Richard L. 3 Edwards, Kathleen M. 5 Martinez, Kenneth F. 6; Affiliation: 1: Office of the Director, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry 2: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases 3: Office of the Director, National Institute for Occupational Safety and Health 4: Bioterrorism Preparedness and Response Program, National Center for Infectious Diseases 5: Office of the Director, Office for Terrorism Preparedness and Emergency Response 6: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health; Source Info: 6/4/2004 Aerosolized Bacillus, Vol. 53 Issue RR-7, p1; Subject Term: BACILLUS anthracis; Subject Term: BACILLUS (Bacteria); Subject Term: ANTHRAX; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Report
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tompkins, Stephen Mark
AU - Chia-Yun Lo
AU - Tumpey, Terrence M.
AU - Epstein, Suzanne L.
T1 - Protection against lethal influenza virus challenge by RNA interference in vivo.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2004/06/08/
VL - 101
IS - 23
M3 - Article
SP - 8682
EP - 8686
SN - 00278424
AB - Influenza virus infection is responsible for hundreds of thousands of deaths annually. Current vaccination strategies and antiviral drugs provide limited protection; therefore, new strategies are needed. RNA interference is an effective means of suppressing virus replication in vitro. Here we demonstrate that treatment with small interfering RNAs (siRNAs) specific for highly conserved regions of the nucleoprotein or acidic polymerase inhibits influenza A virus replication in vivo. Delivery of these siRNAs significantly reduced lung virus titers in infected mice and protected animals from lethal challenge. This protection was specific and not mediated by an antiviral IFN response. Moreover, influenza-specific siRNA treatment was broadly effective and protected animals against lethal challenge with highly pathogenic avian influenza A viruses of the H5 and H7 subtypes. These results indicate that RNA interference is promising for control of influenza virus infection, as well as other viral infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases
KW - AVIAN influenza
KW - RESPIRATORY infections
KW - RNA
KW - INFLUENZA viruses
KW - NUCLEOPROTEINS
KW - ANTIVIRAL agents
N1 - Accession Number: 13679819; Tompkins, Stephen Mark 1 Chia-Yun Lo 1 Tumpey, Terrence M. 2 Epstein, Suzanne L. 1; Email Address: epsteins@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. 2: Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.; Source Info: 6/8/2004, Vol. 101 Issue 23, p8682; Subject Term: VIRUS diseases; Subject Term: AVIAN influenza; Subject Term: RESPIRATORY infections; Subject Term: RNA; Subject Term: INFLUENZA viruses; Subject Term: NUCLEOPROTEINS; Subject Term: ANTIVIRAL agents; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1073/pnas.0402630101
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Munderloh, Ulrike G.
AU - Lynch, Meghan J.
AU - Herron, Michael J.
AU - Palmer, Ann T.
AU - Kurtti, Timothy J.
AU - Nelson, Robert D.
AU - Goodman, Jesse L.
T1 - Infection of endothelial cells with Anaplasma marginale and A. phagocytophilum
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2004/06/10/
VL - 101
IS - 1
M3 - Article
SP - 53
EP - 64
SN - 03781135
AB - Anaplasma marginale and A. phagocytophilum are obligate intracellular, tick-borne pathogens that target erythrocytes and neutrophil granulocytes, respectively. Because ticks do not directly tap blood vessels, an intermediate tissue may mediate infection of blood cells. We considered that vascular endothelium interacts with circulating blood cells in vivo, and could be involved in pathogenesis and dissemination of the organisms. We used light and electron microscopy and immune labeling to show that A. phagocytophilum invaded rhesus (RF/6A), human (HMEC-1, MVEC), as well as bovine (BCE C/D-1b) endothelial cell lines, whereas A. marginale infected rhesus and bovine endothelial cells. A. marginale formed large intracellular inclusions that appeared smooth and solid at first, and subsequently coalesced into discrete granules. A. phagocytophilum formed numerous smaller inclusions in each cell. Within 1–3 weeks, the monolayers were destroyed, and lysed cultures were diluted onto fresh monolayers. Electron microscopy demonstrated uneven distribution of A. marginale inside large inclusions, with reticulated forms grouped more tightly than denser cells, whereas in A. phagocytophilum individual organisms appeared more evenly spaced. Specific polyclonal and monoclonal antibodies both labeled A. marginale and A. phagocytophilum in endothelial cells, and oligonucleotide primers complimentary to either A. marginale or A. phagocytophilum amplified their expected target from these cultures. In conclusion, we demonstrate that relevant microvascular endothelium is susceptible to anaplasmas in vitro and may present a link that could explain development of the immune response and persistent infection. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANAPLASMA marginale
KW - EPITHELIUM
KW - ANAPLASMA
KW - ENDOTHELIUM
KW - Anaplasma culture
KW - Anaplasma marginale
KW - Anaplasma phagocytophilum
KW - Microvascular endothelium
N1 - Accession Number: 13388070; Munderloh, Ulrike G. 1; Email Address: munde001@umn.edu Lynch, Meghan J. 1 Herron, Michael J. 1 Palmer, Ann T. 1 Kurtti, Timothy J. 1 Nelson, Robert D. 2 Goodman, Jesse L. 3; Affiliation: 1: University of Minnesota, Department of Entomology, 219 Hodson Hall, 1980 Folwell Ave., St. Paul, MN 55108, USA 2: University of Minnesota, Department of Dermatology, 420 Delaware, Minneapolis, MN 55455, USA 3: Center for Biologics Evaluation and Research, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Jun2004, Vol. 101 Issue 1, p53; Subject Term: ANAPLASMA marginale; Subject Term: EPITHELIUM; Subject Term: ANAPLASMA; Subject Term: ENDOTHELIUM; Author-Supplied Keyword: Anaplasma culture; Author-Supplied Keyword: Anaplasma marginale; Author-Supplied Keyword: Anaplasma phagocytophilum; Author-Supplied Keyword: Microvascular endothelium; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vetmic.2004.02.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jia, Yiping
AU - Wood, Francine
AU - Menu, Patrick
AU - Faivre, Béatrice
AU - Caron, Alexis
AU - Alayash, Abdu I.
T1 - Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran
JO - BBA - General Subjects
JF - BBA - General Subjects
Y1 - 2004/06/11/
VL - 1672
IS - 3
M3 - Article
SP - 164
EP - 173
SN - 03044165
AB - Human hemoglobin (Hb) conjugated to benzene tetracarboxylate substituted dextran produces a polymeric Hb (Dex-BTC-Hb) with similar oxygen affinity to that of red blood cells (P50=28–29 mm Hg). Under physiological conditions, the oxygen affinity (P50) of Dex-BTC-Hb is 26 mm Hg, while that of native purified human HbA0 is 14 mm Hg, but it exhibits a slight reduction in cooperativity (n50), Bohr effect, and lacks sensitivity to inositol hexaphosphate (IHP), when compared to HbA0. Oxygen-binding kinetics, measured by rapid mixing stopped-flow method showed comparable oxygen dissociation and association rates for both HbA0 and Dex-BTC-Hb. The rate constant for NO-mediated oxidation of the oxy form of Dex-BTC-Hb, which is governed by NO entry to the heme pocket, was reduced to half of the value obtained for HbA0. Moreover, Dex-BTC-Hb is only slightly more sensitive to oxidative reactions than HbA0, as shown by about 2-fold increase in autoxidation, and slightly higher H2O2 reaction and heme degradation rates. Dextran-BTC-based modification of Hb produced an oxygen-carrying compound with increased oxygen release rates, decreased oxygen affinity and reduced nitric oxide scavenging, desirable properties for a viable blood substitute. However, the reduction in the allosteric function of this protein and the lack of apparent quaternary T→R transition may hinder its physiological role as an oxygen transporter. [Copyright &y& Elsevier]
AB - Copyright of BBA - General Subjects is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - BLOOD proteins
KW - OXYGEN
KW - HEMOPROTEINS
KW - Blood substitute
KW - Hemoglobin
KW - Oxygen affinity
KW - Redox reaction
N1 - Accession Number: 13334411; Jia, Yiping 1 Wood, Francine 1 Menu, Patrick 2 Faivre, Béatrice 2 Caron, Alexis 2 Alayash, Abdu I. 1; Email Address: Alayash@cber.fda.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Department of Hematology and Physiology, School of Pharmacy, University of Henri Poincare-Nancy, 54001 Nancy, France; Source Info: Jun2004, Vol. 1672 Issue 3, p164; Subject Term: HEMOGLOBIN; Subject Term: BLOOD proteins; Subject Term: OXYGEN; Subject Term: HEMOPROTEINS; Author-Supplied Keyword: Blood substitute; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: Oxygen affinity; Author-Supplied Keyword: Redox reaction; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bbagen.2004.03.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Selvapandiyan, Angamuthu
AU - Debrabant, Alain
AU - Duncan, Robert
AU - Muller, Jacqueline
AU - Salotra, Poonam
AU - Sreenivas, Gannavaram
AU - Salisbury, Jeffrey L.
AU - Nakhasi, Hira L.
T1 - Centrin Gene Disruption Impairs Stage-specific Basal Body Duplication and Cell Cycle Progression in Leishmania.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/06/11/
VL - 279
IS - 24
M3 - Article
SP - 25703
EP - 25710
SN - 00219258
AB - Centrin is a calcium-binding cytoskeletal protein involved in the duplication of centrosomes in higher eukaryotes. To explore the role of centrin in the protozoan parasite Leishmania, we created Leishmania deficient in the centrin gene (LdCEN). Remarkably, centrin null mutants (LdCEN-/-) showed selective growth arrest as axenic amastigotes but not as promastigotes. Flow cytometry analysis confirmed that the mutant axenic amastigotes have a cell cycle arrest at the G2/M stage. The axenic amastigotes also showed failure of basal body duplication and failure of cytokinesis resulting in multinucleated "large" cells. Increased terminal deoxy uridine triphosphate nick end labeling positivity was observed in centrin mutant axenic amastigotes compared with wild type cells, suggesting the activation of a programmed cell death pathway. Growth of LdCEN-/- amastigotes in infected macrophages in vitro was inhibited and also resulted in large multinucleated parasites. Normal basal body duplication and cell division in the LdCEN knockout promastigote is unique and surprising. Further, this is the first report where disruption of a centrin gene displays stage-specific/cell type-specific failure in cell division in a eukaryote. The centrin null mutant defective in amastigote growth could be useful as a vaccine candidate against leishmaniasis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEISHMANIA
KW - CELLS
KW - CELL proliferation
KW - CELL death
KW - KILLER cells
KW - VACCINATION
N1 - Accession Number: 13808638; Selvapandiyan, Angamuthu 1 Debrabant, Alain 1 Duncan, Robert 1 Muller, Jacqueline 2 Salotra, Poonam 3 Sreenivas, Gannavaram 3 Salisbury, Jeffrey L. 4 Nakhasi, Hira L. 1; Email Address: nakhasi@cber.fda.gov; Affiliation: 1: Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Maryland 2: Laboratory of Vector Borne Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland 3: Institute of Pathology (Indian Council of Medical Research), Safdarjung Hospital, India 4: Tumor Biology Program, Mayo Clinic College of Medicine, Minnesota; Source Info: 6/11/2004, Vol. 279 Issue 24, p25703; Subject Term: LEISHMANIA; Subject Term: CELLS; Subject Term: CELL proliferation; Subject Term: CELL death; Subject Term: KILLER cells; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 12 Color Photographs, 23 Black and White Photographs, 3 Diagrams, 5 Graphs; Document Type: Article
L3 - 10.1074/jbc.M402794200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simak, Jan
AU - Holada, Karel
AU - Risitano, Antonio M.
AU - Zivny, Jan H.
AU - Young, Neal S.
AU - Vostal, Jaroslav G.
T1 - Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2004/06/15/
VL - 125
IS - 6
M3 - Article
SP - 804
EP - 813
PB - Wiley-Blackwell
SN - 00071048
AB - We analysed endothelial cell membrane microparticles (ECMP) in the peripheral blood of patients with paroxysmal nocturnal haemoglobinuria (PNH) ( n = 9), aplastic anaemia (AA) ( n = 10), sickle cell disease (SCD) ( n = 8), and healthy donors (HD) ( n = 11). There was no clinically manifested thrombosis in the PNH or AA group, except one cured thrombophlebitis (PNH), while all SCD patients had a history of vaso-occlusive crises. We used three-colour flow cytometry with blood cell-specific antibodies and antibodies to endothelial antigens CD105 and CD144. Phosphatidylserine-positive microparticles were detected using the annexin V-binding (AVB) assay. The population of CD105+AVB+ ECMP was significantly ( P < 0·05) higher in SCD (median: 0·568 × 109/l; 25–75th percentile range: 0·351–0·976 × 109/l) and PNH (0·401 × 109/l ; 0·19–0·441 × 109/l) patients when compared with AA (0·122 × 109/l; 0·061–0·172 × 109/l) or HD (0·180 × 109/l; 0·137–0·217 × 109/l) group. Even more pronounced differences were observed in ECMP exhibiting a marker of inflammatory stimulation CD54 (CD105+CD54+). Similarly, ECMP that exhibited endothelial specific and proteolysis-sensitive antigen CD144 were increased in SCD and PNH, but not in AA. Elevated CD54+ ECMP may reflect the inflammatory status of endothelial cells in SCD and PNH, while CD144+ ECMP could indicate continuous endothelial stimulation and/or injury. Analysis of circulating ECMP appears promising to provide useful information on the status of the vascular endothelium in PNH and SCD. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL membranes
KW - PAROXYSMAL hemoglobinuria
KW - APLASTIC anemia
KW - SICKLE cell anemia
KW - THROMBOSIS
KW - THROMBOPHLEBITIS
KW - FLOW cytometry
KW - BLOOD cells
KW - IMMUNOGLOBULINS
KW - LIPOCORTINS
KW - adhesion molecules
KW - endothelial cells
KW - flow cytometry
KW - paroxysmal nocturnal haemoglobinuria
KW - sickle cell disease
N1 - Accession Number: 13286061; Simak, Jan 1; Email Address: jan.simak@fda.hhs.gov Holada, Karel 1,2 Risitano, Antonio M. 3 Zivny, Jan H. 1 Young, Neal S. 3 Vostal, Jaroslav G. 1; Affiliation: 1: Laboratory of Cellular Hematology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Institute of Immunology and Microbiology, 1st School of Medicine, Charles University, Prague, Czech Republic 3: Hematolgy Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA; Source Info: Jun2004, Vol. 125 Issue 6, p804; Subject Term: CELL membranes; Subject Term: PAROXYSMAL hemoglobinuria; Subject Term: APLASTIC anemia; Subject Term: SICKLE cell anemia; Subject Term: THROMBOSIS; Subject Term: THROMBOPHLEBITIS; Subject Term: FLOW cytometry; Subject Term: BLOOD cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LIPOCORTINS; Author-Supplied Keyword: adhesion molecules; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: flow cytometry; Author-Supplied Keyword: paroxysmal nocturnal haemoglobinuria; Author-Supplied Keyword: sickle cell disease; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1365-2141.2004.04974.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Camus, Daniel
AU - Djossou, Félix
AU - Schilthuis, Herbert J.
AU - Høgh, Birthe
AU - Dutoit, Emmanuel
AU - Malvy, Denis
AU - Roskell, Neil S.
AU - Hedgley, Corinne
AU - De Boever, Erika H.
AU - Miller, Gerri B.
T1 - Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria Prophylaxis in Nonimmune Pediatric Travelers: Results of an International, Randomized, Open-Label Study.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/06/15/
VL - 38
IS - 12
M3 - Article
SP - 1716
EP - 1723
SN - 10584838
AB - Atovaquone-proguanil has been shown to be effective and well tolerated for malaria prophylaxis in residents of countries of endemicity and in nonimmune adult travelers, but data about traveling children are limited. In a randomized, open-label, multicenter prophylaxis trial, 221 nonimmune pediatric travelers (age, 2-17 years) received either atovaquone-proguanil or chloroquine-proguanil. Safety and clinical outcome were evaluated 7, 28, and 60 days after travel. By posttravel day 7, a total of 39 (35%) of 110 atovaquone-proguanil and 41 (37%) of 111 chloroquine-proguanil recipients reported ⩾1 adverse event. The data indicate that, over the course of treatment, fewer atovaquone-proguanil recipients had treatment-related adverse events (8% vs. 14%), including gastrointestinal complaints (5% vs. 10%). Two subjects discontinued prophylaxis because of drug-related adverse events; both had received chloroquine-proguanil. Observed compliance with prophylaxis was similar before and during travel, but it was higher for atovaquone-proguanil in the posttravel period. No study participant developed malaria. Atovaquone-proguanil was well tolerated and is an important addition to the limited arsenal of prophylactic agents available to children. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Malaria
KW - Travelers
KW - Pediatrics
KW - Gastrointestinal diseases
KW - Fever
KW - Antimalarials
N1 - Accession Number: 13282056; Camus, Daniel 1; Djossou, Félix 2; Schilthuis, Herbert J. 3,4; Høgh, Birthe 5; Dutoit, Emmanuel 1; Malvy, Denis 2; Roskell, Neil S. 6; Hedgley, Corinne 6; De Boever, Erika H. 7; Miller, Gerri B. 8; Affiliations: 1: Institut Pasteur, Lille.; 2: Hôpital Saint-André, Bordeaux, France.; 3: Municipal Public Health Service (GG&GD), Amsterdam.; 4: Health Inspectorate, The Hague, The Netherlands.; 5: International Travel Vaccination Centre, Copenhagen, Denmark.; 6: GlaxoSmithKline, Greenford,United Kingdom.; 7: GlaxoSmithKline, Collegeville, Pennsylvania.; 8: GlaxoSmithKline, Research Triangle Park, North Carolina.; Issue Info: 6/15/2004, Vol. 38 Issue 12, p1716; Thesaurus Term: Malaria; Subject Term: Travelers; Subject Term: Pediatrics; Subject Term: Gastrointestinal diseases; Subject Term: Fever; Subject Term: Antimalarials; NAICS/Industry Codes: 721199 All Other Traveler Accommodation; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Spann, Kirsten M.
AU - Tran, Kim-C.
AU - Bo Chi
AU - Rabin, Ronald L.
AU - Collins, Peter L.
T1 - ERRATUM.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/06/15/
VL - 78
IS - 12
M3 - Correction notice
SP - 6705
EP - 6705
SN - 0022538X
AB - Presents a corrected reprint of an error in an article about virology published in the June 24, issue of "The Journal of Virology."
KW - VIROLOGY
N1 - Accession Number: 13565872; Spann, Kirsten M. 1 Tran, Kim-C. 1 Bo Chi 1 Rabin, Ronald L. 1 Collins, Peter L. 1; Affiliation: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, and Laboratory of Immunobiochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Maryland; Source Info: Jun2004, Vol. 78 Issue 12, p6705; Subject Term: VIROLOGY; Number of Pages: 1p; Document Type: Correction notice
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106561353
T1 - Modeling the level of fortification and post-fortification assessments: U.S. experience...including summary
AU - Yetley EA
AU - Rader JI
Y1 - 2004/06/15/2004 Jun
N1 - Accession Number: 106561353. Language: English. Entry Date: 20050114. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Folic Acid -- United States
KW - Food, Fortified -- United States
KW - Neural Tube Defects -- Prevention and Control -- United States
KW - Cereals
KW - Dietary Reference Intakes
KW - Female
KW - Fetus
KW - Folic Acid -- Adverse Effects
KW - Folic Acid -- Blood
KW - Neural Tube Defects -- Epidemiology
KW - Nutrition Policy
KW - Nutritional Status
KW - Pregnancy
KW - Public Health
KW - United States
KW - United States Food and Drug Administration
KW - Vitamin B12
KW - Women's Health
SP - S50
EP - 61
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 62
IS - 6 part 2
PB - Oxford University Press / USA
SN - 0029-6643
AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740
U2 - PMID: 15298449.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Saviola, James
T1 - Post-Approval Clinical Studies: A Useful Tool for Answering Difficult Questions.
JO - Review of Optometry
JF - Review of Optometry
Y1 - 2004/06/17/6/15/2004 Supplement
VL - 141
M3 - Article
SP - 30
EP - 33
PB - Jobson Publishing, LLC
SN - 1930160X
AB - Explains the importance of post-approval clinical studies in addressing contact lens safety or effectiveness issues that cannot completely be characterized during the pre-approval study. Overview of microbial keratitis or contact lens-related corneal ulcer; Examples of companies that have been give approval by the U.S. Food and Drug Administration to market their contact lenses in the United States; Frequency of post-approval studies.
KW - CONTACT lenses
KW - EYE -- Care & hygiene
KW - OPHTHALMIC lenses
KW - MEDICAL research
KW - PRODUCT safety
KW - UNITED States
N1 - Accession Number: 13618769; Saviola, James 1; Affiliation: 1: Branch Chief, Division of Opthalmic and ENT Devices in the FDA's Office of Device Evaluation, part of the FDA Center for Devices and Radiological Health; Source Info: 6/15/2004 Supplement, Vol. 141, p30; Subject Term: CONTACT lenses; Subject Term: EYE -- Care & hygiene; Subject Term: OPHTHALMIC lenses; Subject Term: MEDICAL research; Subject Term: PRODUCT safety; Subject Term: UNITED States; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423460 Ophthalmic Goods Merchant Wholesalers; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wuilloud, Jorgelina C.A.
AU - Wuilloud, Rodolfo G.
AU - Vonderheide, Anne P.
AU - Caruso, Joseph A.
T1 - Gas chromatography/plasma spectrometry—an important analytical tool for elemental speciation studies
JO - Spectrochimica Acta Part B
JF - Spectrochimica Acta Part B
Y1 - 2004/06/18/
VL - 59
IS - 6
M3 - Article
SP - 755
EP - 792
SN - 05848547
AB - In this review, a full discussion and update of the state-of-the-art of gas chromatography (GC) coupled to all known plasma spectrometers is presented. A brief introductive discussion of the advantages and disadvantages of GC–plasma interfaces, as well as types of plasmas and mass spectrometers, is given. The plasma-based techniques covered include inductively coupled plasma mass spectrometry (ICP-MS) microwave-induced plasma optical emission spectrometry (MIP-OES), and inductively coupled plasma optical emission spectrometry (ICP-OES). Also, different variants of plasma sources, such as low power plasmas and glow discharge (GD) sources, are described and compared with respect to their capabilities in elemental speciation. Recent advances and alternative mass analyzers (collision/reaction cell; time-of-flight; double-focusing sector field) are also mentioned. Different aspects of the GC–plasma coupling are discussed with particular attention to the applications of these hyphenated techniques to the analysis of elemental species. Additionally, classical and modern sample preparation methods, including extraction and/or preconcentration and derivatization reactions, are presented and evaluated. [Copyright &y& Elsevier]
AB - Copyright of Spectrochimica Acta Part B is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAS chromatography
KW - SPECTROMETRY
KW - GLOW discharges
KW - ELECTRIC discharges
KW - Gas chromatography
KW - Glow discharge
KW - ICP
KW - MIP
KW - Plasma spectrometry
KW - Review
KW - Speciation
N1 - Accession Number: 13389774; Wuilloud, Jorgelina C.A. 1,2 Wuilloud, Rodolfo G. 1,2 Vonderheide, Anne P. 1 Caruso, Joseph A. 1; Email Address: joseph.caruso@uc.edu; Affiliation: 1: Department of Chemistry, University of Cincinnati, P.O. Box 0172, Cincinnati, OH 45221-0172, USA 2: U.S. Food and Drug Administration (FDA), Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA; Source Info: Jun2004, Vol. 59 Issue 6, p755; Subject Term: GAS chromatography; Subject Term: SPECTROMETRY; Subject Term: GLOW discharges; Subject Term: ELECTRIC discharges; Author-Supplied Keyword: Gas chromatography; Author-Supplied Keyword: Glow discharge; Author-Supplied Keyword: ICP; Author-Supplied Keyword: MIP; Author-Supplied Keyword: Plasma spectrometry; Author-Supplied Keyword: Review; Author-Supplied Keyword: Speciation; Number of Pages: 38p; Document Type: Article
L3 - 10.1016/j.sab.2004.03.009
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Rathbone, Michael J.
AU - Martinez, Marilyn
T1 - Veterinary drug delivery: Part VI
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2004/06/23/
VL - 56
IS - 10
M3 - Editorial
SP - 1339
EP - 1344
SN - 0169409X
N1 - Accession Number: 13397421; Rathbone, Michael J. 1; Email Address: mjr@interag.co.nz Martinez, Marilyn 2; Email Address: marilyn.martinez@fda.hhs.gov; Affiliation: 1: InterAg, 558 Te Rapa Road, P.O. Box 20055, Hamilton, New Zealand 2: Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Place, HFV-130, Rockville, Maryland 20855, USA; Source Info: Jun2004, Vol. 56 Issue 10, p1339; Number of Pages: 6p; Document Type: Editorial
L3 - 10.1016/j.addr.2004.04.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yan, S. Steve
AU - Gilbert, Jeffrey M.
T1 - Antimicrobial drug delivery in food animals and microbial food safety concerns: an overview of in vitro and in vivo factors potentially affecting the animal gut microflora
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2004/06/23/
VL - 56
IS - 10
M3 - Article
SP - 1497
EP - 1521
SN - 0169409X
AB - This review provides an overview of considerations particular to the delivery of antimicrobial agents to food animals. Antimicrobial drugs are used in food animals for a variety of purposes. These drugs may have therapeutic effects against disease agents, or may cause changes in the structure and/or function of systems within the target animal. Routes of administration, quantity, duration, and potency of an antimicrobial drug are all important factors affecting their action(s) and success. Not only might targeted pathogens be affected, but also bacteria residing in (or on) the treated food animals, especially in the intestines (gastrointestinal tract microflora). Resistance to antimicrobial agents can occur through a number of mechanisms. The extent to which resistance develops is greatly affected by the amount of drug [or its metabolite(s)] a bacterium is exposed to, the duration of exposure, and the interaction between an individual antimicrobial agent and a particular bacterium. The impact of antimicrobial agents on the emergence of resistance in vitro and in vivo may not readily correlate. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - DRUG delivery systems
KW - GASTROINTESTINAL system
KW - FOOD animals
KW - Activity
KW - Antimicrobial agent
KW - Antimicrobial resistance
KW - Food animals
KW - Gastrointestinal tract
KW - In vitro and in vivo
KW - Microflora
N1 - Accession Number: 13397431; Yan, S. Steve 1 Gilbert, Jeffrey M.; Email Address: jgilbert@cvm.fda.gov; Affiliation: 1: Division of Human Food Safety, Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Place, HFV-150, Rockville, MD 20850, USA; Source Info: Jun2004, Vol. 56 Issue 10, p1497; Subject Term: ANTI-infective agents; Subject Term: DRUG delivery systems; Subject Term: GASTROINTESTINAL system; Subject Term: FOOD animals; Author-Supplied Keyword: Activity; Author-Supplied Keyword: Antimicrobial agent; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Food animals; Author-Supplied Keyword: Gastrointestinal tract; Author-Supplied Keyword: In vitro and in vivo; Author-Supplied Keyword: Microflora; Number of Pages: 25p; Document Type: Article
L3 - 10.1016/j.addr.2004.02.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shen, Jing Yu
AU - Kim, Mi Ra
AU - Lee, Chang Joo
AU - Kim, In Seon
AU - Lee, Kang Bong
AU - Shim, Jae Han
T1 - Supercritical fluid extraction of the fluoroquinolones norfloxacin and ofloxacin from orally treated-chicken breast muscles
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2004/06/25/
VL - 513
IS - 2
M3 - Article
SP - 451
EP - 455
SN - 00032670
AB - Supercritical fluid extraction (SFE) of the fluoroquinolones norfloxacin and ofloxacin from chicken breast muscles was examined. A liquid chromatography with fluorescence detection was used for the determination of the fluoroquinolones. Extraction conditions of the SFE were optimized by determining the extraction parameters to achieve a sufficiently high recovery of each fluoroquinolone in fortified-muscle samples. Recovery values for the extraction of the fluoroquinolones using the SFE ranged from 70 to 87%. Chickens were treated orally with each fluoroquinolone and their muscles were extracted at set time intervals for time-course determination of the fluoroquinolones in chickens. The SFE combined with liquid chromatographic analysis showed that the concentrations of the fluoroquinolones decreased gradually with time in the chicken muscles after oral treatment, giving a concentration less than 5 ng/ml in 120 h. No further sample cleanup procedures were required after the SFE. These results suggest that SFE method is an extraction method for the determination of norfloxacin and ofloxacin in chicken muscle. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NORFLOXACIN
KW - QUINOLONE antibacterial agents
KW - CHROMATOGRAPHIC analysis
KW - EXTRACTION (Chemistry)
KW - Fluoroquinolones
KW - Norfloxacin
KW - Ofloxacin
KW - SFE
KW - Supercritical fluid extraction
N1 - Accession Number: 13101039; Shen, Jing Yu 1 Kim, Mi Ra 2 Lee, Chang Joo 3 Kim, In Seon 2 Lee, Kang Bong 4 Shim, Jae Han 2; Email Address: jhshim@chonnam.ac.kr; Affiliation: 1: Chemistry and Biology College, Yantai University, Yantai 264005, China 2: Division of Applied Bioscience and Biotechnology, Institute of Agricultural Science and Technology, College of Agriculture and Life Science, Chonnam National University, 300 Yong-Bong Dong, Buk-ku, Gwangju 500-757, South Korea 3: Department of Civil and Environmental Engineering, Kwangju University, Gwangju 503-703, South Korea 4: Division of Pesticide Residue, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Jun2004, Vol. 513 Issue 2, p451; Subject Term: NORFLOXACIN; Subject Term: QUINOLONE antibacterial agents; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: EXTRACTION (Chemistry); Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Norfloxacin; Author-Supplied Keyword: Ofloxacin; Author-Supplied Keyword: SFE; Author-Supplied Keyword: Supercritical fluid extraction; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.aca.2004.02.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jessouroun, Ellen
AU - da Silveira, Ivna F.B.
AU - Larangeira, Andréa P.
AU - Pereira, Solange
AU - Fernandes, Solange A.
AU - Rabinovitch, Leon
AU - Frasch, Carl E.
AU - Castro-Faria-Neto, Hugo C.
AU - Bozza, Patricia T.
T1 - Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock
JO - Vaccine
JF - Vaccine
Y1 - 2004/06/30/
VL - 22
IS - 20
M3 - Article
SP - 2617
EP - 2625
SN - 0264410X
AB - Neisseria meningitidis (N. meningitidis) is a serious bacterial pathogen that causes life-threatening invasive bacterial infections especially in children below 2 years of age, teenagers and young adults. We have investigated the protective potential of outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains. Swiss mice were immunized with different combinations of OMV and dLOS from N. meningitidis serogroup B strains compared to a reference vaccine (VA-MENGOC-BC®, Cuba). The OMVs + dLOS from Brazilian prevalent strains induced higher bactericidal antibody titers against homologous and heterologous target strains and stronger inhibition of thrombocytopenia as compared to the reference vaccine. When the challenge was performed with the B strain, all immunogens tested showed similar survival rates (80%) significantly higher than the control group. Bacterial clearance against the group B strain was comparable for animals immunized with the tested immunogen and the reference vaccine. Inclusion of dLOS from the B strain with the OMV, induced a similar clearance of C strain bacteria as compared to VA-MENGOC-BC®. The immunogens, as well as the reference vaccine drastically inhibited increases in TNF-α and IL-6 plasma levels after challenge. In conclusion, the OMV/dLOS formulation obtained from Brazilian prevalent strains of N. meningitidis has a remarkable performance protecting mice against the lethal effects of meningococcal challenge showing a good potential as a vaccine and should be considered for clinical evaluation. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic microorganisms
KW - Immunization
KW - Bacterial diseases
KW - Neisseria meningitidis
KW - Cytokines
KW - N. meningitidis vaccines
KW - Outer membrane vesicles
N1 - Accession Number: 13387706; Jessouroun, Ellen 1; Email Address: ellen@bio.fiocruz.br; da Silveira, Ivna F.B. 1; Larangeira, Andréa P. 1,2; Pereira, Solange 1; Fernandes, Solange A. 1; Rabinovitch, Leon 3; Frasch, Carl E. 4; Castro-Faria-Neto, Hugo C. 2; Bozza, Patricia T. 2; Affiliations: 1: Laboratório de Tecnologias Bacterianas, Departamento de Desenvolvimento Tecnológico—Bio-Manguinhos, FIOCRUZ, Rio de Janeiro, RJ, Brazil; 2: Laboratório Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, FIOCRUZ, Rio de Janeiro, RJ, Brazil; 3: Departamento de Bacteriologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil; 4: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Issue Info: Jun2004, Vol. 22 Issue 20, p2617; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Immunization; Thesaurus Term: Bacterial diseases; Subject Term: Neisseria meningitidis; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: N. meningitidis vaccines; Author-Supplied Keyword: Outer membrane vesicles; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2003.12.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106592157
T1 - Putting prevention into practice. Counseling for breastfeeding.
AU - Guirguis-Blake J
Y1 - 2004/07//7/1/2004
N1 - Accession Number: 106592157. Language: English. Entry Date: 20050311. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Breast Feeding
KW - Breast Feeding Promotion
KW - Counseling -- Methods
KW - Adult
KW - Education, Continuing (Credit)
KW - Female
KW - Pregnancy
KW - Prenatal Care
SP - 149
EP - B
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 70
IS - 1
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Medical Officer, U.S. Preventive Services Task Force Agency for Healthcare Research and Quality Center for Primary Care, Prevention, and Clinical Partnerships
U2 - PMID: 15259530.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Macher, Abe
AU - Kibble, Deborah
AU - Schuster-Walken, Marmie
T1 - Mycobacterium Avium Complex and the Immune Reconstitution Inflammatory Syndrome.
JO - American Jails
JF - American Jails
Y1 - 2004/07//Jul/Aug2004
VL - 18
IS - 3
M3 - Article
SP - 65
EP - 67
SN - 10560319
AB - Describes several clinical presentations of inmates with mycobacterium avium complex (MAC) associated immune reconstitution inflammatory syndrome in jails in the U.S. Diagnosis of a male patient with AIDS; Treatment of patient with AIDS and a history of MAC; Description of an exuberant immune response to a subclinical infection following the initiation of highly active antiretroviral therapy.
KW - PRISONERS
KW - DISEASES
KW - MYCOBACTERIUM avium
KW - AIDS (Disease)
KW - IMMUNE response
KW - ANTIRETROVIRAL agents
KW - UNITED States
N1 - Accession Number: 14097173; Macher, Abe 1 Kibble, Deborah 2 Schuster-Walken, Marmie 3; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland 2: nursing supervisor, Prince William Manassas Regional Adult Detention Center, Manassas, Virginia 3: Chronic Care Nurse, Prince William-Manassas Regional Adult Detention Center, Manassas, Virginia; Source Info: Jul/Aug2004, Vol. 18 Issue 3, p65; Subject Term: PRISONERS; Subject Term: DISEASES; Subject Term: MYCOBACTERIUM avium; Subject Term: AIDS (Disease); Subject Term: IMMUNE response; Subject Term: ANTIRETROVIRAL agents; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McNeil, Melodi J.
T1 - FDA video news show.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2004/07//7/1/2004
VL - 61
IS - 13
M3 - Article
SP - 1340
EP - 1340
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Presents the "FDA Patient Safety News" video news show produced by the U.S. Food and Drug Administration. Aim of the show to bring important patient safety information to busy health care professionals; Information provided on medical errors, patient safety, product recalls and new products approved by the agency; Television networks broadcasting the show.
KW - TELEVISION programs
KW - PATIENTS
KW - MEDICAL personnel
KW - MEDICAL errors
KW - PRODUCT recall
KW - NEW product development
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - FDA Patient Safety News (TV program)
N1 - Accession Number: 13642650; McNeil, Melodi J. 1; Email Address: mcneilm@cder.fda.gov; Affiliation: 1: Special Assistant to the Director, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, HFD-030, Room 15B-03, Rockville, MD; Source Info: 7/1/2004, Vol. 61 Issue 13, p1340; Subject Term: TELEVISION programs; Subject Term: PATIENTS; Subject Term: MEDICAL personnel; Subject Term: MEDICAL errors; Subject Term: PRODUCT recall; Subject Term: NEW product development; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Reviews & Products: FDA Patient Safety News (TV program); NAICS/Industry Codes: 541613 Marketing Consulting Services; NAICS/Industry Codes: 512110 Motion Picture and Video Production; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calonge, Ned
T1 - Screening for Syphilis Infection: Recommendation Statement.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2004/07//Jul/Aug2004
VL - 2
IS - 4
M3 - Article
SP - 362
EP - 365
PB - Annals of Family Medicine
SN - 15441709
AB - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for syphilis and the supporting scientific evidence, and updates the 1996 recommendations contained in the "Guide to Clinical Preventive Services." Populations at increased risk for syphilis infection include men who have sex with men and engage in high-risk sexual behavior, commercial sex workers, persons who exchange sex for drugs, and those in adult correctional facilities. Prevalence of syphilis infection varies widely among communities and patient populations.
KW - SYPHILIS -- Diagnosis
KW - SEXUALLY transmitted diseases
KW - SYPHILIS
KW - DRUG abuse
KW - HOMOSEXUALITY
KW - UNITED States
N1 - Accession Number: 14078412; Calonge, Ned 1; Email Address: usptf@ahrq.gov; Affiliation: 1: Chair, U.S. Preventive Services Task Force, Program Director USPSTF Agency for Healthcare Research and Quality 540 Gaither Road Rockville, MD 20850.; Source Info: Jul/Aug2004, Vol. 2 Issue 4, p362; Subject Term: SYPHILIS -- Diagnosis; Subject Term: SEXUALLY transmitted diseases; Subject Term: SYPHILIS; Subject Term: DRUG abuse; Subject Term: HOMOSEXUALITY; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
L3 - 10.1370/afm.215
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14078412&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calonge, Ned
T1 - Screening for Syphilis Infection: Recommendation Statement.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2004/07//Jul/Aug2004
VL - 2
IS - 4
M3 - Article
SP - 362
EP - 365
PB - Annals of Family Medicine
SN - 15441709
AB - This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for syphilis and the supporting scientific evidence, and updates the 1996 recommendations contained in the "Guide to Clinical Preventive Services." Populations at increased risk for syphilis infection include men who have sex with men and engage in high-risk sexual behavior, commercial sex workers, persons who exchange sex for drugs, and those in adult correctional facilities. Prevalence of syphilis infection varies widely among communities and patient populations.
KW - SYPHILIS -- Diagnosis
KW - SEXUALLY transmitted diseases
KW - SYPHILIS
KW - DRUG abuse
KW - HOMOSEXUALITY
KW - UNITED States
N1 - Accession Number: 14078412; Calonge, Ned 1; Email Address: usptf@ahrq.gov; Source Information: Jul/Aug2004, Vol. 2 Issue 4, p362; Subject: SYPHILIS -- Diagnosis; Subject: SEXUALLY transmitted diseases; Subject: SYPHILIS; Subject: DRUG abuse; Subject: HOMOSEXUALITY; Geographic Terms: UNITED States; Number of Pages: 4p; Document Type: Article
L3 - 10.1370/afm.215
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=14078412&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Yildirim, Suleyman
AU - Wen Lin
AU - Hitchins, Anthony D.
AU - Jaykus, Lee-Ann
AU - Altermann, Eric
AU - Klaenhammer, Todd R.
AU - Kathariou, Sophia
T1 - Epidemic Clone I-Specific Genetic Markers in Strains of Listeria monocytogenes Serotype 4b from Foods.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/07//
VL - 70
IS - 7
M3 - Article
SP - 4158
EP - 4164
SN - 00992240
AB - Listeria monocytogenes contamination of ready-to-eat foods has been implicated in numerous outbreaks of food-borne listeriosis. However, the health hazards posed by L. monocytogenes detected in foods may vary, and speculations exist that strains actually implicated in illness may constitute only a fraction of those that contaminate foods. In this study, examination of 34 serogroup 4 (putative or confirmed serotype 4b) isolates of L. monocytogenes obtained from various foods and food-processing environments, without known implication in illness, revealed that many of these strains had methylation of cytosines at GATC sites in the genome, rendering their DNA resistant to digestion by the restriction endonuclease Sau3AI. These strains also harbored a gene cassette with putative restriction-modification system genes as well as other, genomically unlinked genetic markers characteristic of the major epidemic-associated lineage of L. monocytogenes (epidemic clone I), implicated in numerous outbreaks in Europe and North America. This may reflect a relatively high fitness of strains with these genetic markers in foods and food-related environments relative to other serotype 4b strains and may partially account for the repeated involvement of such strains in human food.borne listeriosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - BIOCHEMICAL markers
KW - GENETIC markers
KW - LISTERIOSIS
KW - BACTERIAL diseases
KW - GENES
KW - NUCLEIC acids
N1 - Accession Number: 13951000; Yildirim, Suleyman 1 Wen Lin 2 Hitchins, Anthony D. 3 Jaykus, Lee-Ann 1 Altermann, Eric 1 Klaenhammer, Todd R. 1 Kathariou, Sophia 1; Email Address: skathar@unity.ncsu.edu; Affiliation: 1: Department of Food Science, North Carolina State University, Raleigh, North Carolina 2: Food and Drug Administration, Irvine, California 3: Food and Drug Administration, Washington; Source Info: Jul2004, Vol. 70 Issue 7, p4158; Subject Term: LISTERIA monocytogenes; Subject Term: BIOCHEMICAL markers; Subject Term: GENETIC markers; Subject Term: LISTERIOSIS; Subject Term: BACTERIAL diseases; Subject Term: GENES; Subject Term: NUCLEIC acids; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.70.7.4158-4164.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, J.
AU - Jinneman, K.
AU - Stelma, G.
AU - Smith, B.G.
AU - Lye, D.
AU - Messer, J.
AU - Ulaszek, J.
AU - Evsen, L.
AU - Gendel, S.
AU - Bennett, R.W.
AU - Swaminathan, B.
AU - Pruckler, J.
AU - Steigerwalt, A.
AU - Kathariou, S.
AU - Yildirim, S.
AU - Volokhov, D.
AU - Rasooly, A.
AU - Chizhikov, V.
AU - Wiedmann, M.
AU - Fortes, E.
T1 - Natural Atypical Listeria innocua Strains with Listeria monocytogenes Pathogenicity Island 1 Genes.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/07//
VL - 70
IS - 7
M3 - Article
SP - 4256
EP - 4266
SN - 00992240
AB - Identification of bona fide Listeria isolates into the six species of the genus normally requires only a few tests. Aberrant isolates do occur, but even then only one or two extra confirmatory tests are generally needed for identification to species level. We have discovered a hemolytic-positive, rhamnose and xylose fermentationnegative Listeria strain with surprising recalcitrance to identification to the species level due to contradictory results in standard confirmatory tests. The issue had to be resolved by using total DNA-DNA hybridization testing and then confirmed by further specific PCR-based tests including a Listeria microarray assay. The results show that this isolate is indeed a novel one. Its discovery provides the first fully documented instance of a hemolytic Listeria innocua strain. This species, by definition, is typically nonhemolytic. The L. innocua isolate contains all the members of the PrfA. regulated virulence gene cluster (Listeria pathogenicity island 1) of L. monocytogenes. It is avirulent in the mouse pathogenicity test. Avirulence is likely at least partly due to the absence of the L. monocytogenes-specific allele of iap, as well as the absence of inlA, inlB, inlC, and daaA. At least two of the virulence cluster genes, hly and plcA, which encode the L. monocytogenes hemolysin (listeriolysin O) and inositol-specific phospholipase C, respectively, are phenotypically expressed in this L. innocua strain. The detection by PCR assays of specific L. innocua genes (linO198,1in0372,1in0419,1in0558, lin1068,1in1073,1in1074, lin2454, and iin2693) and noncoding intergenic regions (lino454-1in0455 and nadA-lin2134) in the strain is consistent with its L. innocua DNA-DNA hybridization identity. Additional distinctly different hemolytic L. innocua strains were also studied. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - DNA
KW - NUCLEIC acids
KW - HYBRIDIZATION
KW - INOSITOL
KW - PHOSPHOINOSITIDES
KW - VITAMIN B complex
N1 - Accession Number: 13951013; Johnson, J. 1 Jinneman, K. 1 Stelma, G. 2 Smith, B.G. 2 Lye, D. 2 Messer, J. 2 Ulaszek, J. 3 Evsen, L. 4 Gendel, S. 5 Bennett, R.W. 5 Swaminathan, B. 6 Pruckler, J. 6 Steigerwalt, A. 6 Kathariou, S. 7 Yildirim, S. 7 Volokhov, D. 8 Rasooly, A. 5 Chizhikov, V. 8 Wiedmann, M. 9 Fortes, E. 9; Affiliation: 1: Food and Drug Administration, Bothell, Washington, Cincinnati, Ohio 2: Environmental Protection Agency, Cincinnati, Ohio 3: National Center for Food Safety and Technology, Summit-Argo, Illinois 4: University of Maryland College Park, Maryland 5: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 6: Center for Disease Control and Prevention, Atlanta, Georgia 7: North Carolina State University, Raleigh, North Carolina 8: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 9: Cornell University, Ithaca, New York; Source Info: Jul2004, Vol. 70 Issue 7, p4256; Subject Term: LISTERIA monocytogenes; Subject Term: DNA; Subject Term: NUCLEIC acids; Subject Term: HYBRIDIZATION; Subject Term: INOSITOL; Subject Term: PHOSPHOINOSITIDES; Subject Term: VITAMIN B complex; Number of Pages: 11p; Illustrations: 3 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1128/AEM.70.7.4256-4266.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schenck, F. J.
AU - Hobbs, J. E.
T1 - Evaluation of the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) Approach to Pesticide Residue Analysis.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 2004/07//
VL - 73
IS - 1
M3 - Article
SP - 24
EP - 30
PB - Springer Science & Business Media B.V.
SN - 00074861
AB - This article focuses on pesticide residue analysis. Recently, a rapid and inexpensive approach to the analysis of pesticide residues in fruits and vegetables was reported. minutes by a single analyst. The Quick, Easy, Cheap, Effective, Rugged and Safe method entails extracting the pesticide residues from 10 g of sample by vortex mixing with 10 ml of acetonitrile. No mechanical homogenizers or blenders are used. Water is removed from the extract by salting out with sodium chloride and magnesium sulfate and a subsequent cleanup of the acetonitrile extract is performed by vortexing an aliquot of the extract with a small quantity of solid phase extraction (SPE) sorbent.
KW - Pesticides
KW - Agricultural chemicals
KW - Vegetables
KW - Alkali metals
KW - Acetonitrile
KW - Fruit -- Development
N1 - Accession Number: 15410651; Schenck, F. J. 1; Hobbs, J. E. 1; Affiliations: 1: Southeast Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth Street NE, Atlanta, GA 30309, USA.; Issue Info: Jul2004, Vol. 73 Issue 1, p24; Thesaurus Term: Pesticides; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Vegetables; Thesaurus Term: Alkali metals; Thesaurus Term: Acetonitrile; Subject Term: Fruit -- Development; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s00128-004-0388-y
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Volpe, Donna A.
AU - LoRusso, Patricia M.
AU - Foster, Brenda J.
AU - Parchment, Ralph E.
T1 - In vitro and in vivo effects of acetyldinaline on murine megakaryocytopoiesis.
JO - Cancer Chemotherapy & Pharmacology
JF - Cancer Chemotherapy & Pharmacology
Y1 - 2004/07//
VL - 54
IS - 1
M3 - Article
SP - 89
EP - 94
SN - 03445704
AB - Purpose. Acetyldinaline (CI-994) has shown preclinical efficacy in vitro and in vivo against solid tumor and leukemia cell lines. Since myelosuppression was the dose-limiting toxicity for acetyldinaline in preclinical and clinical studies, experiments were conducted to examine the in vitro and in vivo effects of acetyldinaline on murine megakaryocytic (CFU-meg) progenitor cells. Methods. Bone marrow and spleen cells from untreated mice were continuously exposed in vitro to acetyldinaline or dinaline in clonal assays. For the in vivo study, BDF1 mice were dosed orally with 50 mg/kg acetyldinaline every day for 14 days. Results. Both acetyldinaline and dinaline induced an in vitro dose-dependent decrease in CFU-meg colonies derived from either the spleen or bone marrow. Splenic CFU-meg were more sensitive in vitro to acetyldinaline and dinaline than their marrow counterparts. In the in vivo experiments, platelet counts decreased throughout the 14-day dosing period and had returned to normal by day 18. Marrow and spleen CFU-meg declined after the first dose but had recovered by days 4 and 7, respectively. Elevated splenic CFU-meg counts were observed through day 20, 6 days after dosing ended. Recovery of platelet counts in treated mice was associated with increases in both marrow and splenic CFU-meg. Conclusions. There was differential in vitro toxicity of acetyldinaline to murine CFU-meg derived from the bone marrow versus spleen. The in vitro assay predicted the more severe effect of acetyldinaline on splenic progenitors than on their marrow counterparts that was observed in the in vivo phase. In addition, megakaryocytopoiesis in the marrow showed evidence of recovery from drug toxicity in the face of continuing daily acetyldinaline treatments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEGAKARYOCYTES
KW - CELL lines
KW - MYELOID leukemia
KW - IMMUNOSUPPRESSION
KW - MICE as laboratory animals
KW - BONE marrow cells
KW - Acetyldinaline
KW - CFU-meg
KW - In vitro
KW - In vivo
KW - Mice
KW - Platelets
N1 - Accession Number: 16821418; Volpe, Donna A. 1,2 LoRusso, Patricia M. 3 Foster, Brenda J. 3,4 Parchment, Ralph E. 1,5; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 2: Food and Drug Administration, HFD-940, Life Sciences Bldg. 64, 10903 New Hampshire Ave., MD 20993, Silver Spring, USA 3: Wayne State University, School of Medicine, Detroit, MI, USA 4: Sanofi-Synthelabo, Malvern, PA, USA 5: Karmanos Cancer Institute, Detroit, MI, USA; Source Info: Jul2004, Vol. 54 Issue 1, p89; Subject Term: MEGAKARYOCYTES; Subject Term: CELL lines; Subject Term: MYELOID leukemia; Subject Term: IMMUNOSUPPRESSION; Subject Term: MICE as laboratory animals; Subject Term: BONE marrow cells; Author-Supplied Keyword: Acetyldinaline; Author-Supplied Keyword: CFU-meg; Author-Supplied Keyword: In vitro; Author-Supplied Keyword: In vivo; Author-Supplied Keyword: Mice; Author-Supplied Keyword: Platelets; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Powers, John H.
AU - Ross, David B.
AU - Lin, Daphne
AU - Soreth, Janice
AU - Wunderink, Richard G.
AU - Kollef, Marin
AU - Rello, Jordi
T1 - Linezolid and Vancomycin for Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia.
JO - CHEST
JF - CHEST
Y1 - 2004/07//
VL - 126
IS - 1
M3 - Letter
SP - 314
EP - 316
PB - American College of Chest Physicians
SN - 00123692
AB - Presents a letter to the editor commenting on R.G. Wunderink and colleagues' article on the association between the initial therapy with linezolid and better survival and clinical cure rates compared to that with vancomycin in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus.
KW - LETTERS to the editor
KW - VANCOMYCIN
KW - PNEUMONIA
KW - STAPHYLOCOCCUS aureus
N1 - Accession Number: 13948572; Powers, John H. 1; Email Address: POWERSJOH@cder.fda.gov Ross, David B. 1 Lin, Daphne 1 Soreth, Janice 1 Wunderink, Richard G. 2; Email Address: r-wunderink@northwestern.edu Kollef, Marin 3 Rello, Jordi 4; Affiliation: 1: US Food and Drug Administration, Rockville, MD 2: Northwestern University Feinberg School of Medicine, Chicago, IL 3: Washington University School of Medicine, St. Louis, MO 4: University Rovira I Virgili, Tarragona, Spain; Source Info: Jul2004, Vol. 126 Issue 1, p314; Subject Term: LETTERS to the editor; Subject Term: VANCOMYCIN; Subject Term: PNEUMONIA; Subject Term: STAPHYLOCOCCUS aureus; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Åstrand, Per
AU - Engquist, Bo
AU - Anzén, Bengt
AU - Bergendal, Tom
AU - Hallman, Mats
AU - Karlsson, Ulf
AU - Kvint, Sven
AU - Lysell, Leif
AU - Rundcranz, Torgil
T1 - A Three-Year Follow-Up Report of a Comparative Study of ITI Dental Implants® and Brånemark System® Implants in the Treatment of the Partially Edentulous Maxilla.
JO - Clinical Implant Dentistry & Related Research
JF - Clinical Implant Dentistry & Related Research
Y1 - 2004/07//
VL - 6
IS - 3
M3 - Article
SP - 16
EP - 141
SN - 15230899
AB - Background: Many longitudinal studies of different implant systems have been published but few controlled randomized investigations have been reported. A 1-year report of a comparative study of ITI Dental Implant System® implants (Straumann AG, Waldenburg, Switzerland) and Brånemark System® implants (Nobel Biocare AB, Gothenburg, Sweden) has been published by the present authors. This paper is a 3-year follow-up of that randomized study. Purpose: The aim of the study was to compare the outcome of fixed partial prostheses supported by ITI or Brånemark implants. The outcome was evaluated primarily in terms of survival rates and changes in marginal bone level. Material and Methods: The study group comprised 28 patients with anterior residual dentition in the maxilla. The patients were provided with two to four implants on each side of the dentition and were randomly allocated to Brånemark implants or ITI implants; 77 ITI implants and 73 Brånemark implants were inserted. After 6 months abutment connections were made to both ITI and Brånemark implants. All patients were provided with fixed partial prostheses of gold-ceramic. The patients were followed up annually with clinical and radiographic examinations for 3 years. Results: Two Brånemark implants and two ITI implants were lost. The Brånemark implants were lost before loading whereas the ITI implants were lost because of periimplantitis. The survival rate for both groups was 97.3%. The mean marginal bone level of the Brånemark implants was situated 1,8 mm from the reference point at both the baseline and the 3-year examinations. The corresponding values for the ITI implants were 1.4 mm at baseline and 1.3 mm after 3 years. There was no significant difference between the implant systems with regard to bone level or bone level change. A steady state of the marginal bone level was calculated to have been reached after 3 years for 95.5% of the Brånemark implants and 87.1% of the ITI implants. Periimplantitis (infection including pus and bone loss) was observed with seven ITI implants but with none of the Brånemark implants. This difference was statistically significant. Conclusions: No statistically significant differences were found between the implants studied, except for the frequency of periimplantitis, which was higher for the ITI implants. The survival rates were high, and the marginal bone loss was small for both systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Implant Dentistry & Related Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL implants
KW - MAXILLA
KW - ORAL surgery
KW - DENTISTRY
KW - RESEARCH
KW - Brånemark System®
KW - comparative study
KW - implants
KW - ITI dental implants
KW - marginal bone change
KW - randomized study
N1 - Accession Number: 15236308; Åstrand, Per 1 Engquist, Bo 2 Anzén, Bengt 3 Bergendal, Tom 4 Hallman, Mats 5 Karlsson, Ulf 6 Kvint, Sven 7 Lysell, Leif 8 Rundcranz, Torgil 9; Affiliation: 1: Department of Oral and Maxillofacial Surgery, University Hospital, Linköping, Sweden 2: Department of Prosthodontics, Centre of Oral Rehabilitation, Linköping, Sweden 3: Department of Oral and Maxillofacial Surgery, Vrinnevi Hospital, Norrköping, Sweden 4: Department of Prosthetic Dentistry, Institute of Postgraduate Dental Education, Jönköping, Sweden 5: Department of Oral and Maxillofacial Surgery, Public Health Service, Gävle Hospital, Gävle, Sweden 6: Department of Prosthodontics, Specialist Dental Centre, Norrköping, Sweden 7: Department of Oral and Maxillofacial Surgery, Institute of Postgraduate Dental Education, Jönkoping, Sweden 8: Department of Oral and Maxillofacial Surgery, Kristianstad Hospital, Kristianstad, Sweden 9: Department of Prosthodontics, Public Dental Health, Kristianstad, Sweden; Source Info: 2004, Vol. 6 Issue 3, p16; Subject Term: DENTAL implants; Subject Term: MAXILLA; Subject Term: ORAL surgery; Subject Term: DENTISTRY; Subject Term: RESEARCH; Author-Supplied Keyword: Brånemark System®; Author-Supplied Keyword: comparative study; Author-Supplied Keyword: implants; Author-Supplied Keyword: ITI dental implants; Author-Supplied Keyword: marginal bone change; Author-Supplied Keyword: randomized study; Number of Pages: 12p; Illustrations: 1 Color Photograph, 2 Black and White Photographs, 1 Diagram, 8 Charts, 4 Graphs; Document Type: Article; Full Text Word Count: 6472
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jackson, Andre J.
AU - Robbie, Gabriel
AU - Marroum, Patrick
T1 - Metabolites and Bioequivalence Past and Present.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2004/07//
VL - 43
IS - 10
M3 - Article
SP - 655
EP - 672
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Although it is widely recognised that measurement of metabolite concentrations is crucial to understanding the clinical pharmacology characteristics of a new molecular entity, a clear consensus on the role of metabolites in the assessment of bioequivalence has never been achieved within the scientific community. However, a regulatory policy for the role of metabolites in bioavailability and bioequivalence has been established by the US FDA. One school of thought believes that the parent drug alone is sensitive to picking up formulation differences, whereas another school of thought believes that establishing bioequivalence criteria on all the species that contribute to safety and efficacy is the only way to ensure the switchability of two products. In this paper, a brief review of the pharmacokinetics of metabolites under different scenarios is presented and the history of the role of metabolites in the assessment of bioequivalence is summarised. Relevant examples from the literature illustrating conflicting opinions on the need for the measurement of metabolites in bioequivalence studies are given. Cases from the literature in which the parent drug is able to meet the 90% confidence intervals while the metabolite(s) fail to do so, and vice versa, are presented to illustrate the difficulty in choosing the pertinent entity to measure. The relevant current US FDA policy and guide- lines related to bioavailability and bioequivalence are discussed and contrasted with the rules and regulations applicable in Canada and Europe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - DRUGS -- Therapeutic equivalency
KW - PHARMACOKINETICS
KW - PHARMACOLOGY
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 14246699; Jackson, Andre J. 1 Robbie, Gabriel 1 Marroum, Patrick 2; Affiliation: 1: Division of Pharmaceutical Evaluation I, Center for Drug Evaluation and Research, Food. 2: Drug Administration, Office of Clinical Pharmacology and Biopharmaceutics, Rockville, Maryland, USA.; Source Info: 2004, Vol. 43 Issue 10, p655; Subject Term: METABOLITES; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: PHARMACOKINETICS; Subject Term: PHARMACOLOGY; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Okamura, M.
AU - Lillehoj, H.S.
AU - Raybourne, R.B.
AU - Babu, U.S.
AU - Heckert, R.A.
T1 - Cell-mediated immune responses to a killed Salmonella enteritidis vaccine: lymphocyte proliferation, T-cell changes and interleukin-6 (IL-6), IL-1, IL-2, and IFN-γ production
JO - Comparative Immunology, Microbiology & Infectious Diseases
JF - Comparative Immunology, Microbiology & Infectious Diseases
Y1 - 2004/07//
VL - 27
IS - 4
M3 - Article
SP - 255
EP - 272
SN - 01479571
AB - Two experimental approaches were used to investigate the immunological responses of chickens to a commercial killed Salmonella enteritidis (SE) vaccine. In the first, the effects of host age on antigen-specific proliferative responses and cytokine production were examined. Compared with non-vaccinated controls, 4-wk-old vaccinated chickens showed higher proliferation to SE LPS and flagella. The lymphoproliferation responses to these antigens of 8-mo-old vaccinated chickens were not different compared to the non-vaccinated controls. Increased production of interferon-γ (IFN-γ) and interleukin-2 (IL-2) by antigen-stimulated splenocytes following vaccination were, in general, more often observed in 4-wk-old compared with 8-mo-old chickens, whereas serum levels of these cytokines were consistently higher in the vaccinated birds compared with controls regardless of age. The second set of experiments were designed to determine the effects of SE vaccination on mitogen- or antigen-induced splenocyte proliferation and serum nitric oxide (NO) and cytokine levels. Splenocytes from vaccinated chickens stimulated with SE flagella showed significantly increased numbers of TCRγδ+ cells at 7 days post-vaccination compared with non-vaccinated birds. In contrast, no differences were noted with CD4+, CD8+, or TCRαβ+ cells at any time points examined. Higher levels of NO production were observed following stimulation with SE flagella at 4, 7, 11, and 14 days after SE vaccination while serum levels of IFN-γ, IL-1, IL-6, and IL-8 were elevated only at day 7 post-vaccination. In conclusion, younger chickens mounted a more robust antigen-specific immune response to the SE vaccine compared with older birds and vaccination induced not only T-cell-mediated responses but also host innate and pro-inflammatory responses. (English) [Copyright &y& Elsevier]
AB - Deux approches expe´rimentales ont e´te´ utilise´es pour examiner les re´actions immunologiques de poulets au vaccin tue´ commercial Salmonella enteritidis. La premie`re visait a` observer les effets de l'aˆge du sujet sur les re´actions prolife´ratives spe´cifiques aux antige`nes et la production de cytokine. Par comparaison avec des te´moins non vaccine´s, les poulets de 4 semaines vaccine´s ont montre´ un taux supe´rieur de prolife´ration de LPS et flagelles de SE. Les re´actions de lymphoprolife´ration a` ces antige`nes chez des poulets vaccine´s aˆge´s de 8 mois n'e´taient pas diffe´rentes de celles de te´moins non vaccine´s. On a en ge´ne´ral observe´ l'augmentation de la production d'interfe´rone-γ (IFN-γ) et d'interleukine-2 (IL-2) par des sple´nocytes stimule´s par des antige`nes a` la suite de la vaccination plus souvent chez des poulets de 4 semaines que chez des poulets de 8 mois, tandis que les niveaux de se´rum de ces cytokines e´taient re´gulie`rement plus e´leve´s chez les volatiles vaccine´s que chez les te´moins non vaccine´s, quel que soit leur aˆge.La seconde se´rie d'expe´riences e´tait conc¸ue pour de´terminer les effets de la vaccination SE sur la prolife´ration de sple´nocytes cause´e par des mitoge`nes ou des antige`nes, et sur les niveaux d'oxyde nitrique (NO) et de cytokine. Les sple´nocytes de poulets vaccine´s stimule´s avec flagelles SE montraient des taux de cellules TCRγδ+ beaucoup plus e´leve´s a` 7 jours apre`s la vaccination que ceux de volatiles non vaccine´s. Des taux de production de NO supe´rieurs e´taient observables a` la suite d'une stimulation avec flagelle SE a` 4, 7, 11 et 14 jours apre`s vaccination SE tandis que les niveaux de IFN-γ, IL-1, IL-6, et IL-8 n'e´taient supe´rieurs qu'au 7e`me jour apre`s la vaccination. En conclusion, des poulets plus jeunes ont te´moigne´ d'une re´ponse immunitaire spe´cifique aux antige`nes au vaccin SE plus forte que celle de volatiles plus aˆge´s, et la vaccination a produit non seulement des re´ponses me´diatise´es par les cellules T mais aussi des re´ponses inne´es et pro-inflammatoires chez les sujets. (French) [Copyright 2004 Elsevier]
AB - Copyright of Comparative Immunology, Microbiology & Infectious Diseases is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - IMMUNE response
KW - IMMUNOLOGY
KW - VACCINES
KW - VACCINATION
KW - VACCINATION of animals
KW - VETERINARY immunology
KW - CHICKENS
KW - Cell proliferation
KW - Chicken
KW - Cytokines
KW - DTH, delayed-type hypersensitivity
KW - FCS, fetal calf serum
KW - HBSS, Hanks' balanced salt solution
KW - HK-SE, heat-killed SE
KW - Killed vaccine
KW - OMP, outer membrane protein
KW - PBS-T, PBS containing 0.05% Tween
KW - ppi, post-primary immunization
KW - psi, post-secondary immunization
KW - RPMI-10, RPMI-1640 medium supplemented with 10% fetal calf serum and 100 U/ml penicillin and 100 μg/ml streptomycin
KW - Salmonella enteritidis
KW - SE, Salmonella enteritidis
KW - SI, stimulation index
KW - WST-8, 2-[2-methoxy-4-nitrophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H-tetrazolium, monosodium salt
KW - Poulet
KW - Prolifération des cellules
KW - Vaccin tué
N1 - Accession Number: 13333119; Okamura, M. 1 Lillehoj, H.S. 1; Email Address: hlilleho@anri.barc.usda.gov Raybourne, R.B. 2 Babu, U.S. 2 Heckert, R.A. 3; Affiliation: 1: Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, USDA-ARS, BARC-East, Building 1043, Beltsville, MD 20705, USA 2: Immunobiology Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA 3: Department of Avian Diseases, VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA; Source Info: Jul2004, Vol. 27 Issue 4, p255; Subject Term: SALMONELLA enteritidis; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: VACCINES; Subject Term: VACCINATION; Subject Term: VACCINATION of animals; Subject Term: VETERINARY immunology; Subject Term: CHICKENS; Author-Supplied Keyword: Cell proliferation; Author-Supplied Keyword: Chicken; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: DTH, delayed-type hypersensitivity; Author-Supplied Keyword: FCS, fetal calf serum; Author-Supplied Keyword: HBSS, Hanks' balanced salt solution; Author-Supplied Keyword: HK-SE, heat-killed SE; Author-Supplied Keyword: Killed vaccine; Author-Supplied Keyword: OMP, outer membrane protein; Author-Supplied Keyword: PBS-T, PBS containing 0.05% Tween; Author-Supplied Keyword: ppi, post-primary immunization; Author-Supplied Keyword: psi, post-secondary immunization; Author-Supplied Keyword: RPMI-10, RPMI-1640 medium supplemented with 10% fetal calf serum and 100 U/ml penicillin and 100 μg/ml streptomycin; Author-Supplied Keyword: Salmonella enteritidis; Author-Supplied Keyword: SE, Salmonella enteritidis; Author-Supplied Keyword: SI, stimulation index; Author-Supplied Keyword: WST-8, 2-[2-methoxy-4-nitrophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H-tetrazolium, monosodium salt; Author-Supplied Keyword: Poulet; Author-Supplied Keyword: Prolifération des cellules; Author-Supplied Keyword: Vaccin tué; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.cimid.2003.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tan, Yongxi
AU - Shi, Leming
AU - Tong, Weida
AU - Gene Hwang, G.T.
AU - Wang, Charles
T1 - Multi-class tumor classification by discriminant partial least squares using microarray gene expression data and assessment of classification models
JO - Computational Biology & Chemistry
JF - Computational Biology & Chemistry
Y1 - 2004/07//
VL - 28
IS - 3
M3 - Article
SP - 235
EP - 243
SN - 14769271
AB - High-throughput DNA microarray provides an effective approach to the monitoring of expression levels of thousands of genes in a sample simultaneously. One promising application of this technology is the molecular diagnostics of cancer, e.g. to distinguish normal tissue from tumor or to classify tumors into different types or subtypes. One problem arising from the use of microarray data is how to analyze the high-dimensional gene expression data, typically with thousands of variables (genes) and much fewer observations (samples). There is a need to develop reliable classification methods to make full use of microarray data and to evaluate accurately the predictive ability and reliability of such derived models. In this paper, discriminant partial least squares was used to classify the different types of human tumors using four microarray datasets and showed good prediction performance. Four different cross-validation procedures (leave-one-out versus leave-half-out; incomplete versus full) were used to evaluate the classification model. Our results indicate that discriminant partial least squares using leave-half-out cross-validation provides a more realistic estimate of the predictive ability of a classification model, which may be overestimated by some of the cross-validation procedures, and the information obtained from different cross-validation procedures can be used to evaluate the reliability of the classification model. [Copyright &y& Elsevier]
AB - Copyright of Computational Biology & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - GENES
KW - TUMORS
KW - NUCLEIC acids
KW - DPLS
KW - Leave-half-out cross-validation
KW - Microarray
KW - Reliability
KW - Classification
N1 - Accession Number: 13804947; Tan, Yongxi 1 Shi, Leming 2 Tong, Weida 2 Gene Hwang, G.T. 3 Wang, Charles 1; Email Address: charles.wang@cshs.org; Affiliation: 1: Burns and Allen Research Institute Microarray Core, Cedars-Sinai Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA 2: Center for Toxicoinformatics, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: Department of Mathematics, Cornell University, Cornell, NY 14850, USA; Source Info: Jul2004, Vol. 28 Issue 3, p235; Subject Term: DNA; Subject Term: GENES; Subject Term: TUMORS; Subject Term: NUCLEIC acids; Author-Supplied Keyword: DPLS; Author-Supplied Keyword: Leave-half-out cross-validation; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Reliability; Author-Supplied Keyword: Classification; Language of Keywords: English; Language of Keywords: German; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.compbiolchem.2004.05.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biddle, Elyce Anne
T1 - THE ECONOMIC COST OF FATAL OCCUPATIONAL INJURIES IN THE UNITED STATES, 1980-97.
JO - Contemporary Economic Policy
JF - Contemporary Economic Policy
Y1 - 2004/07//
VL - 22
IS - 3
M3 - Article
SP - 370
EP - 381
SN - 10743529
AB - According to the National Traumatic Occupational Fatalities (NTOF) surveillance system, occupational injuries claimed the lives of over 100,000 American workers from 1980 to 1997. Previous estimates presented aggregate values of life, providing no information on the cost variations for different case or worker characteristics. This research developed an interactive computer program that estimates comprehensive national costs for all occupational fatal injuries reported through NTOF, nearly $85 billion for 1980-97, and specific estimates for the burden on selected groups and characteristics of the fatality. These estimates provide an additional basis for targeting and evaluating the effectiveness of investments in prevention of occupational fatalities. (JEL I18). [ABSTRACT FROM AUTHOR]
AB - Copyright of Contemporary Economic Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ECONOMICS
KW - RESEARCH
KW - EMPLOYEES
KW - OCCUPATIONS
KW - UNITED States
KW - Health and Human Resources
N1 - Accession Number: 13672582; Biddle, Elyce Anne 1; Email Address: Ebbiddle@cdc.gov; Affiliations: 1 : Chief, Methods and Analysis Team, Analysis and Field Evaluations Branch, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS/1811, Centers for Disease Control and Prevention, Morgantown, WV 26505; Source Info: Jul2004, Vol. 22 Issue 3, p370; Subject Term: ECONOMICS; Subject Term: RESEARCH; Subject Term: EMPLOYEES; Subject Term: OCCUPATIONS; Subject: UNITED States; Author-Supplied Keyword: Health and Human Resources; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
AU - Misbin, Robert I.
T1 - The Phantom of Lactic Acidosis due to Metformin in Patients With Diabetes.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2004/07//
VL - 27
IS - 7
M3 - Article
SP - 1791
EP - 1793
SN - 01495992
AB - Comments on research findings on the risk of lactic acidosis from metformin use by patients with diabetes. Lingering concerns that metformin might also cause lactic acidosis; Safety concerns regarding the drug; Implications on diabetes research.
KW - DIABETIC acidosis
KW - ACIDOSIS
KW - KETOACIDOSIS
KW - DRUGS
KW - DIABETES
KW - ENDOCRINE diseases
N1 - Accession Number: 13681685; Misbin, Robert I. 1; Email Address: misbim@cder.fda.gov; Affiliation: 1: Division of Endocrinology and Metabolism, U.S. Food and Drug Administration, Rockville, Maryland; Source Info: Jul2004, Vol. 27 Issue 7, p1791; Subject Term: DIABETIC acidosis; Subject Term: ACIDOSIS; Subject Term: KETOACIDOSIS; Subject Term: DRUGS; Subject Term: DIABETES; Subject Term: ENDOCRINE diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 2199
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volokhov, Dmitriy
AU - Pomerantsev, Andrei
AU - Kivovich, Violetta
AU - Rasooly, Avraham
AU - Chizhikov, Vladimir
T1 - Identification of Bacillus anthracis by multiprobe microarray hybridization
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2004/07//
VL - 49
IS - 3
M3 - Article
SP - 163
EP - 171
SN - 07328893
AB - We have developed a rapid assay based on microarray analysis of amplified genetic markers for reliable identification of Bacillus anthracis and its discrimination from other closely related bacterial species of the Bacillus cereus group. By combining polymerase chain reaction (PCR) amplification of six B. anthracis-specific genes (plasmid-associated genes encoding virulence factors (cyaA, pagA, lef, and capA, capB, capC) and one chromosomal marker BA-5449) with analysis of amplicons by microarray hybridization, we were able to unambiguously identify and discriminate B. anthracis among other closely related species. Bacillus identification relied on hybridization with multiple individual microarray oligonucleotide probes (oligoprobes) specific to each target B. anthracis gene. Evaluation of the assay was conducted using several B. anthracis strains (with or without pXO1 and pXO2 plasmids) as well as over 50 other species phylogenetically related to B. anthracis, including B. cereus, B. thuringiensis, B. mycoides, and B. subtilis. The developed microarray analysis of amplified genetic markers protocol provides an efficient method for (i) unambiguous identification and discrimination of B. anthracis from other Bacillus species and (ii) distinguishing between plasmid-containing and plasmid-free Bacillus anthracis strains. [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC markers
KW - BACILLUS anthracis
KW - BACILLUS cereus
KW - NUCLEIC acid probes
KW - Anthrax toxins
KW - Multiplex PCR
KW - pXO1
KW - pXO2
KW - Virulence factors
N1 - Accession Number: 13703745; Volokhov, Dmitriy 1 Pomerantsev, Andrei 2 Kivovich, Violetta 2 Rasooly, Avraham 3 Chizhikov, Vladimir 1; Email Address: chizhikov@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, MD 20895, USA 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA; Source Info: Jul2004, Vol. 49 Issue 3, p163; Subject Term: GENETIC markers; Subject Term: BACILLUS anthracis; Subject Term: BACILLUS cereus; Subject Term: NUCLEIC acid probes; Author-Supplied Keyword: Anthrax toxins; Author-Supplied Keyword: Multiplex PCR; Author-Supplied Keyword: pXO1; Author-Supplied Keyword: pXO2; Author-Supplied Keyword: Virulence factors; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2004.03.015
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Watson, Christopher
AU - Woodcock, Janet
T1 - Janet Woodcock discusses the FDA and the drug development process
JO - Drug Discovery Today
JF - Drug Discovery Today
Y1 - 2004/07//
VL - 9
IS - 13
M3 - Editorial
SP - 548
EP - 550
SN - 13596446
AB - T1 recovering signal, yields higher quality DENSE myocardial strain maps. Phantom and human images are provided to demonstrate the technique, which is capable of acquiring phase contrast displacement encoded images at low encoding gradient strengths providing better spatial resolution and less signal loss due to intravoxel dephasing than prior methods. [Copyright &y& Elsevier]
AB - Copyright of Journal of Magnetic Resonance is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIAC contraction
KW - IMAGING systems in medicine
KW - ECHO
KW - ACOUSTIC phenomena in nature
KW - Cardiac
KW - Contraction
KW - DENSE
KW - Function
KW - HARP
KW - Heart
KW - MRI
KW - Myocardial
KW - SPAMM
KW - Tagging
N1 - Accession Number: 13808412; Aletras, Anthony H.; Email Address: AletrasA@nhlbi.nih.gov Arai, Andrew E. 1; Affiliation: 1: Laboratory of Cardiac Energetics, US Department of Health and Human Services, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD, USA; Source Info: Aug2004, Vol. 169 Issue 2, p246; Subject Term: CARDIAC contraction; Subject Term: IMAGING systems in medicine; Subject Term: ECHO; Subject Term: ACOUSTIC phenomena in nature; Author-Supplied Keyword: Cardiac; Author-Supplied Keyword: Contraction; Author-Supplied Keyword: DENSE; Author-Supplied Keyword: Function; Author-Supplied Keyword: HARP; Author-Supplied Keyword: Heart; Author-Supplied Keyword: MRI; Author-Supplied Keyword: Myocardial; Author-Supplied Keyword: SPAMM; Author-Supplied Keyword: Tagging; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jmr.2004.05.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eller, Nancy
AU - Golding, Hana
AU - Inoue, Satoshi
AU - Beining, Paul
AU - Inman, John
AU - Matthews, Natasha
AU - Scott, Dorothy E.
AU - Golding, Basil
T1 - Systemic and mucosal immunity in rhesus macaques immunized with HIV-1 peptide and gp120 conjugated to Brucella abortus.
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
Y1 - 2004/08//
VL - 33
IS - 4
M3 - Article
SP - 167
EP - 174
PB - Wiley-Blackwell
SN - 00472565
AB - HIV vaccine testing in primates is an important method for determining the possibility of vaccine benefit in humans. Goals of HIV-1 vaccination include establishing neutralizing antibodies and a strong CD8+ T-cell response. We tested a novel vaccine conjugate for its ability to elicit relevant immune responses to HIV proteins and peptides in rhesus macaques. A neutralizing epitope, V3 loop peptide from HIV-1 envelope, was coupled to heat-inactivated Brucella abortus (V3-HKBA). Rhesus macaques were immunized with this conjugate in the anterior thigh. After two immunizations V3-specific antibodies were found in the sera and at mucosal sites. Neutralizing activity of these antibodies was demonstrated by syncytia inhibition assays. Cellular immune recall responses were demonstrated by antigen-specific induction of interferon-gamma and Regulation on Activation Noraml T Cell Expressed and Secreted (RANTES) secretion in vitro. These results confirm and extend preliminary studies in mice that suggest HKBA is an effective carrier that promotes neutralizing antibody secretion at relevant mucosal sites, as well as cellular immune responses that are correlated with viral protection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Medical Primatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACAQUES
KW - HIV (Viruses)
KW - VACCINATION
KW - COMMUNICABLE diseases -- Prevention
KW - RHESUS monkey
KW - VETERINARY vaccines
KW - VETERINARY medicine
KW - CD8+ T cells
KW - interferon-gamma
KW - tumor necrosis factor
KW - V3-peptide
KW - antibodies
N1 - Accession Number: 13662287; Eller, Nancy 1 Golding, Hana 2 Inoue, Satoshi 1 Beining, Paul 1 Inman, John 3 Matthews, Natasha 1 Scott, Dorothy E. 1 Golding, Basil 1; Email Address: golding@cber.fda.gov; Affiliation: 1: Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Bethesda, MD 2: Laboratory of Retrovirus Research, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 3: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Source Info: Aug2004, Vol. 33 Issue 4, p167; Subject Term: MACAQUES; Subject Term: HIV (Viruses); Subject Term: VACCINATION; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: RHESUS monkey; Subject Term: VETERINARY vaccines; Subject Term: VETERINARY medicine; Author-Supplied Keyword: CD8+ T cells; Author-Supplied Keyword: interferon-gamma; Author-Supplied Keyword: tumor necrosis factor; Author-Supplied Keyword: V3-peptide; Author-Supplied Keyword: antibodies; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1600-0684.2004.00068.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - March, John
AU - Kratochvil, Christopher
AU - Clarke, Gregory
AU - Beardslee, William
AU - Derivan, Albert
AU - Emslie, Graham
AU - Green, Evelyn P.
AU - Heiligenstein, John
AU - Hinshaw, Stephen
AU - Hoagwood, Kimberly
AU - Jensen, Peter
AU - Lavori, Philip
AU - Leonard, Henrietta
AU - McNulty, James
AU - Michaels, M. Alex
AU - Mossholder, Andrew
AU - Osher, Trina
AU - Petti, Theodore
AU - Prentice, Ernest
AU - Vitiello, Benedetto
T1 - AACAP 2002 Research Forum: Placebo and Alternatives to Placebo in Randomized Controlled Trials in Pediatric Psychopharmacology.
JO - Journal of the American Academy of Child & Adolescent Psychiatry
JF - Journal of the American Academy of Child & Adolescent Psychiatry
Y1 - 2004/08//
VL - 43
IS - 8
M3 - Article
SP - 1046
EP - 1056
SN - 08908567
AB - Objective: The use of placebo in the pediatric age group has come under increasing scrutiny. At the 2002 Annual Meeting of the American Academy of Child and Adolescent Psychiatry, the Academy's Workgroup on Research conducted a research forum. The purpose was to identify challenges and their solutions regarding the use of placebo in randomized controlled trials in pediatric psychopharmacology. Method: Workgroups focused on problems and solutions in five areas: ethics and human subjects, research design and statistics, partnering with consumers, U.S. Food and Drug Administration and pharmaceutical industry perspectives, and psychosocial treatments. Results: In many but not all circumstances, inclusion of a placebo control is essential to meet the scientific goals of treatment outcome research. Innovative research designs; involvement of consumers in planning and implementing research; flexibility by industry, academia, the National Institutes of Health, and regulatory agencies acting in partnership; and concomitant use of evidence-based psychosocial services can and should assist in making placebo-controlled trials acceptable. Conclusions: Properly designed placebo-controlled trials remain necessary, ethical, and feasible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLACEBOS (Medicine)
KW - PSYCHOPHARMACOLOGY
KW - PEDIATRICIANS
KW - PSYCHIATRY
KW - PATHOLOGICAL psychology
KW - MENTAL health
KW - adolescence.
KW - placebo
KW - psychopharmacology
KW - randomized controlled trial
KW - treatment
N1 - Accession Number: 14011571; March, John 1; Email Address: jsmarch@acpub.duke.edu Kratochvil, Christopher 2 Clarke, Gregory 3 Beardslee, William 4 Derivan, Albert 5 Emslie, Graham 6 Green, Evelyn P. 7 Heiligenstein, John 8 Hinshaw, Stephen 9 Hoagwood, Kimberly 10 Jensen, Peter 10 Lavori, Philip 11 Leonard, Henrietta 12 McNulty, James 13 Michaels, M. Alex 14 Mossholder, Andrew 15 Osher, Trina 16 Petti, Theodore 17 Prentice, Ernest 2 Vitiello, Benedetto 18; Affiliation: 1: Duke University Medical Center, Durham, NO. 2: University of Nebraska Medical Center, Omaha. 3: Kaiser Permanente Center for Health Research, Portland OR. 4: Harvard Medical School, Boston. 5: Johnson and Johnson Pharmaceuticals 6: University of Texas, Southwestern Medical Branch. 7: Children and Adults with Attention Deficit Disorder, Landover, MD. 8: Eli Lilly, Inc., Indianapolis, IN. 9: University of California, Berkeley. 10: Columbia University, NY. 11: Stanford University, CA. 12: Brown University, Providence, RI. 13: National Alliance for the Mentally Ill, Arlington, VA. 14: Shire Pharmaceutical Development. Inc., Hampshire, UK. 15: US. Food and Drug Administration, Rockville, MD. 16: Federation of Families for Children's Mental Health, Alexandria, VA. 17: Indiana University Medical Center, Indianapolis. 18: National Institute of Mental Health. Bethesda, MD.; Source Info: Aug2004, Vol. 43 Issue 8, p1046; Subject Term: PLACEBOS (Medicine); Subject Term: PSYCHOPHARMACOLOGY; Subject Term: PEDIATRICIANS; Subject Term: PSYCHIATRY; Subject Term: PATHOLOGICAL psychology; Subject Term: MENTAL health; Author-Supplied Keyword: adolescence.; Author-Supplied Keyword: placebo; Author-Supplied Keyword: psychopharmacology; Author-Supplied Keyword: randomized controlled trial; Author-Supplied Keyword: treatment; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1097/01.chi.0000129606.83206.77
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14011571&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mitchell, Abigail E.
AU - Bakshi, Kulbir S.
AU - Kimmel, Carole A.
AU - Buck, Germaine M.
AU - Feuston, Maureen H.
AU - Foster, Paul M.D.
AU - Friedman, J.M.
AU - Holson, Joseph F.
AU - Hughes, Claude L.
AU - Moore, John A.
AU - Schwetz, Bernard A.
AU - Scialli, Anthony R.
AU - Scott Jr., William J.
AU - Vorhees, Charles V.
AU - Zirkin, Barry R.
T1 - Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/08//
VL - 67
IS - 15/16
M3 - Article
SP - 1159
EP - 1314
SN - 15287394
AB - Reports on the U.S. National Research Council's recommended approach to evaluate chemical and physical agents for their potential to cause reproductive and developmental toxicity. Recommendations made by the Council's Board on Environmental Studies and Toxicology's Committee on Toxicology; Abigail E. Mitchell's appointment as project director; Concern regarding reproductive and developmental hazards in the workplace; U.S. Navy's efforts to protect military and civilian personnel from reproductive and developmental hazards in the workplace.
KW - TOXICITY testing
KW - CHEMICAL warfare agents
KW - POISONS
KW - TOXICOLOGY
KW - UNITED States
KW - NATIONAL Research Council (U.S.)
KW - UNITED States. Navy
N1 - Accession Number: 13379726; Mitchell, Abigail E. 1 Bakshi, Kulbir S. 1; Email Address: Kbakshi@nas.edu Kimmel, Carole A. 2 Buck, Germaine M. 3 Feuston, Maureen H. 4 Foster, Paul M.D. 5 Friedman, J.M. 6 Holson, Joseph F. 7 Hughes, Claude L. 8 Moore, John A. 9 Schwetz, Bernard A. 10 Scialli, Anthony R. 11 Scott Jr., William J. 12 Vorhees, Charles V. 12 Zirkin, Barry R. 13; Affiliation: 1: National Research Council, Washington, DC 2: US Environmental Protection Agency, Washington, DC 3: State University of New York, Buffalo, NY 4: Sanofi Pharmaceuticals, Malvern, PA 5: Chemical Industry Institute of Technology, Research Triangle Park, NC 6: University of British Columbia, Vancouver, British Columbia 7: WIL Research Lab., Ashland, OH 8: Cedars-Sinai Medical Center, Los Angeles, CA 9: Insitute for Evaluating Health Risks, Washington, DC 10: National Center for Toxicological Research, Rockville, MD 11: Georgetown University Medical Center, Washington, DC 12: University of Cincinnati College of Medicine, Cincinnati, OH 13: Johns Hopkins University School of Public Health, Baltimore, MD; Source Info: 2004, Vol. 67 Issue 15/16, p1159; Subject Term: TOXICITY testing; Subject Term: CHEMICAL warfare agents; Subject Term: POISONS; Subject Term: TOXICOLOGY; Subject Term: UNITED States; Company/Entity: NATIONAL Research Council (U.S.) Company/Entity: UNITED States. Navy; NAICS/Industry Codes: 928110 National Security; Number of Pages: 156p; Document Type: Article
L3 - 10.1080/15287390490460994
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clavet, Charles R.
AU - Margolin, Aaron B.
AU - Regan, Patrick M.
T1 - Herpes simplex virus type-2 specific glycoprotein G-2 immunomagnetically captured from HEp-2 infected tissue culture extracts
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004/08//
VL - 119
IS - 2
M3 - Article
SP - 121
EP - 128
SN - 01660934
AB - Monoclonal antibody H1206 anti-HSV-2 gG-2 bound to tosylactivated paramagnetic Dynabeads® (Dynal®) has been used to isolate HSV-2 type-specific gG-2 from solubilized HEp-2 HSV-2 infected cell extracts. The immunomagnetically captured type-specific glycoprotein reacted strongly with monoclonal antibody H1206 and demonstrated a single band with apparent molecular weight of 100,000 (100 kDa) and a doublet band with an apparent molecular weight of 60,000–64,000 (60–64 kDa). We observed the same exact banding pattern when monoclonal H1206 was immunoblotted with Helix pomatia lectin purified HSV-2 gG-2. The immunomagnetically purified gG-2 was unreactive to monoclonal antibody H1379 anti-HSV-1 gG-1 and four human HSV antibody negative sera. In addition, 20 human HSV antibody positive sera obtained from the Centers for Disease Control (CDC), Atlanta, GA, were used for the evaluation of our methodology. Immunoblotting of the human HSV antibody positive samples were in agreement with the CDC HSV serological designation. Sera characterized by reactivity to the immunomagnetically purified gG-2 in conjunction with Western blot has the potential to be used as a confirmatory serological test or to determine the accuracy of clinical serological immunoassays used to determine HSV-2 seropositivity. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - HERPESVIRUS diseases
KW - GLYCOPROTEINS
KW - LECTINS
KW - Glycoprotein G-2
KW - HSV-2
KW - Immunomagnetic separation
KW - Type-specific gG-2
N1 - Accession Number: 13178977; Clavet, Charles R. 1; Email Address: cclavet@ora.fda.gov Margolin, Aaron B. 2 Regan, Patrick M. 1; Affiliation: 1: US Food and Drug Administration, Winchester Engineering and Analytical Center, Winchester, MA 01890, USA 2: University of New Hampshire, Durham, NH 03824, USA; Source Info: Aug2004, Vol. 119 Issue 2, p121; Subject Term: IMMUNOGLOBULINS; Subject Term: HERPESVIRUS diseases; Subject Term: GLYCOPROTEINS; Subject Term: LECTINS; Author-Supplied Keyword: Glycoprotein G-2; Author-Supplied Keyword: HSV-2; Author-Supplied Keyword: Immunomagnetic separation; Author-Supplied Keyword: Type-specific gG-2; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jviromet.2004.03.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Rong-Fu
AU - Beggs, Marjorie L.
AU - Erickson, Bruce D.
AU - Cerniglia, Carl E.
T1 - DNA microarray analysis of predominant human intestinal bacteria in fecal samples
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2004/08//
VL - 18
IS - 4
M3 - Article
SP - 223
EP - 234
SN - 08908508
AB - A microarray method was developed for the detection of 40 bacterial species reported in the literature to be predominant in the human gastrointestinal tract. The 40 species include seven species each of Bacteroides and Clostridium, six species of Ruminococcus, five species of Bifidobacterium, four species of Eubacterium, two species each of Fusobacterium, Lactobacillus and Enterococcus, and single species each of Collinsella, Eggerthella, Escherichia, Faecalibacterium and Finegoldia. Three 40-mer oligos specific for each bacterial species were designed based on comparison of the 16S rDNA sequences available in the GenBank database, and were used to make the DNA-array on epoxy slides. Using two universal primers, the 16S rRNA gene from bacteria present in fecal samples were amplified and labeled with Cyanine5-dCTP by PCR, and then hybridized to the DNA-array. After resolving some difficulties caused by sequence conflicts in GenBank and inaccurate reference strains, all 40 bacterial reference species gave positive results. The microarray method was used to screen fecal samples obtained from 11 healthy human volunteers for the presence of these intestinal bacteria. The results indicated that 25–37 of the 40 species could be detected in each fecal sample and that 33 of the species were found in a majority of the samples. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FECAL microbiology
KW - PROTEIN microarrays
KW - GASTROINTESTINAL diseases
KW - BACTEROIDES
KW - 16S rRNA gene amplification
KW - Fecal samples
KW - Human intestinal bacteria
KW - Microarray
KW - PCR
N1 - Accession Number: 13905862; Wang, Rong-Fu 1; Email Address: rwang@nctr.fda.gov Beggs, Marjorie L. 2 Erickson, Bruce D. 1 Cerniglia, Carl E. 1; Affiliation: 1: Microbiology Division, National Center for Toxicological Research, US-FDA, 3900 NCTR Rd, Jefferson, AR 72079, USA 2: Department of Geriatrics, Microarray Core Facility, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Source Info: Aug2004, Vol. 18 Issue 4, p223; Subject Term: FECAL microbiology; Subject Term: PROTEIN microarrays; Subject Term: GASTROINTESTINAL diseases; Subject Term: BACTEROIDES; Author-Supplied Keyword: 16S rRNA gene amplification; Author-Supplied Keyword: Fecal samples; Author-Supplied Keyword: Human intestinal bacteria; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: PCR; Language of Keywords: English; Language of Keywords: German; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.mcp.2004.03.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barmada, Sami
AU - Piccardo, Pedro
AU - Yamaguchi, Keiji
AU - Ghetti, Bernardino
AU - Harris, David A.
T1 - GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice
JO - Neurobiology of Disease
JF - Neurobiology of Disease
Y1 - 2004/08//
VL - 16
IS - 3
M3 - Article
SP - 527
EP - 537
SN - 09699961
AB - Prion diseases result from conversion of PrPC, a neuronal membrane glycoprotein of unknown function, into PrPSc, an abnormal conformer that is thought to be infectious. To facilitate analysis of PrP distribution in the brain, we have generated transgenic mice in which a PrP promoter drives expression of PrP-EGFP, a fusion protein consisting of enhanced green fluorescent protein inserted adjacent to the glycolipid attachment site of PrP. We find that PrP-EGFP in the brain is glycosylated and glycolipid-anchored and is localized to the surface membrane and the Golgi apparatus of neurons. Like endogenous PrP, PrP-EGFP is concentrated in synapse-rich regions and along axon tracts. PrP-EGFP is functional in vivo, since it ameliorates the cerebellar neurodegeneration induced by a truncated form of PrP. These observations clarify uncertainties in the cellular localization of PrPC in brain, and they establish PrP-EGFP transgenic mice as useful models for further studies of prion biology. [Copyright &y& Elsevier]
AB - Copyright of Neurobiology of Disease is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GREEN fluorescent protein
KW - TRANSGENIC mice
KW - NERVOUS system
KW - GLYCOLIPIDS
KW - Brain
KW - Golgi apparatus
KW - Prion
N1 - Accession Number: 13808456; Barmada, Sami 1 Piccardo, Pedro 2,3 Yamaguchi, Keiji 2 Ghetti, Bernardino 2 Harris, David A. 1; Email Address: dharris@cellbio.wustl.edu; Affiliation: 1: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA 2: Division of Neuropathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA; Source Info: Aug2004, Vol. 16 Issue 3, p527; Subject Term: GREEN fluorescent protein; Subject Term: TRANSGENIC mice; Subject Term: NERVOUS system; Subject Term: GLYCOLIPIDS; Author-Supplied Keyword: Brain; Author-Supplied Keyword: Golgi apparatus; Author-Supplied Keyword: Prion; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.nbd.2004.05.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slatin, Craig
AU - Estabrook, Tom
T1 - WE ARE THE KEEPERS OF THE ENVIRONMENT: AN INTERVIEW WITH STEPHEN L. GAUTHIER, HEALTH AND SAFETY ACTIVIST, MEMBER OF IUE/CWA LOCAL 201.
JO - New Solutions: A Journal of Environmental & Occupational Health Policy
JF - New Solutions: A Journal of Environmental & Occupational Health Policy
Y1 - 2004/08//
VL - 14
IS - 3
M3 - Article
SP - 263
EP - 271
SN - 10482911
AB - Interviews Stephen Gauthier, a machinist at the General Electric facility in Lynn, Massachusetts, concerning a variety of health and safety and environmental health issues relevant to union organizing. His works on the field of health and safety and environmental health; Obstacles to the working relationship between labor unions and environmentalists; Approach in convincing labor leaders to support precautionary legislation.
KW - Environmental health
KW - Health
KW - Safety
KW - Labor organizing
KW - Machinists
KW - Labor unions
KW - Gauthier, Stephen -- Interviews
N1 - Accession Number: 15118431; Slatin, Craig 1,2; Email Address: Craig_Slatin@uml.com; Estabrook, Tom; Email Address: Thomas_Estabrook@uml.edu; Affiliations: 1: Assistant Professor, Health Education and Policy, Department of Health and Clinical Science, University of Massachusetts Lowell; 2: Principal investigator, National Institute for Occupational Safety and Health; Issue Info: 2004, Vol. 14 Issue 3, p263; Thesaurus Term: Environmental health; Thesaurus Term: Health; Thesaurus Term: Safety; Subject Term: Labor organizing; Subject Term: Machinists; Subject Term: Labor unions; NAICS/Industry Codes: 813930 Labor Unions and Similar Labor Organizations; People: Gauthier, Stephen -- Interviews; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Biagini, R. E.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - Page, E. H.
AU - Snawder, J. E.
AU - Striley, C. A. F.
AU - MacKenzie, B. A.
T1 - Determination of serum IgG antibodies to Bacillus anthracis protective antigen in environmental sampling workers using a fluorescent covalent microsphere immunoassay.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2004/08//
VL - 61
IS - 8
M3 - Article
SP - 703
EP - 708
SN - 13510711
AB - Aims: To evaluate potential exposure to Bacillis anthracis (Ba) spores in sampling/decontamination workers in the aftermath of an anthrax terror attack. Methods: Fifty six serum samples were obtained from workers involved in environmental sampling for Ba spores at the American Media, Inc. (AMI) building in Boca Raton, FL after the anthrax attack there in October 2001. Nineteen sera were drawn from individuals both pre-entry and several weeks after entrance into the building. Nine sera each were drawn from unique individuals at the pre-entry and follow up blood draws. Thirteen donor control sera were also evaluated. Individuals were surveyed for Ba exposure by measurement of serum Ba anti-protective antigen (PA) specific IgG antibodies using a newly developed fluorescent covalent microsphere immunoassay (FCMIA). Results: Four sera gave positive anti-PA IgG results (defined as anti-PA IgG concentrations ≥ the mean µg/ml anti-PA IgG from donor control sera (n = 13 plus 2 SD which were also inhibited ≥ 85% when the serum was pre-adsorbed with PA). The positive sera were the pre-entry and follow up samples of two workers who had received their last dose of anthrax vaccine in 2000. Conclusion: It appears that the sampling/decontamination workers of the present study either had insufficient exposure to Ba spores to cause the production of anti-PA IgG antibodies or they were exposed to anthrax spores without producing antibody. The FCMIA appears to be a fast, sensitive, accurate, and precise method for the measurement of anti-PA IgG antibodies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacillus anthracis
KW - VACCINATION
KW - Environmental sampling
KW - Anthrax
KW - Serum
KW - Terrorism
KW - Immunoassay
KW - American Media Inc.
N1 - Accession Number: 14096538; Biagini, R. E. 1; Email Address: rbiagini@cdc.gov; Sammons, D. L. 1; Smith, J. P. 1; Page, E. H. 2; Snawder, J. E. 1; Striley, C. A. F. 1; MacKenzie, B. A. 1; Affiliations: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, US; 2: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincin; Issue Info: Aug2004, Vol. 61 Issue 8, p703; Thesaurus Term: Bacillus anthracis; Thesaurus Term: VACCINATION; Thesaurus Term: Environmental sampling; Subject Term: Anthrax; Subject Term: Serum; Subject Term: Terrorism; Subject Term: Immunoassay ; Company/Entity: American Media Inc.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1136/oem.2003.008565
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106660382
T1 - Immunizations: important at every stage of life.
AU - Cochi SL
Y1 - 2004/08//2004 Aug
N1 - Accession Number: 106660382. Language: English. Entry Date: 20041105. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9890954.
KW - Immunization -- Trends -- In Adolescence
KW - Immunization -- Trends -- In Old Age
KW - Adolescence
KW - Aged
KW - Chickenpox Vaccine -- Administration and Dosage
KW - Influenza Vaccine -- Administration and Dosage
KW - Measles-Mumps-Rubella Vaccine -- Administration and Dosage
KW - Middle Age
KW - World Wide Web
SP - 90
EP - 93
JO - Patient Education Management
JF - Patient Education Management
JA - PATIENT EDUC MANAGE
VL - 11
IS - 8
CY - Atlanta, Georgia
PB - AHC Media LLC
SN - 1087-0296
AD - Captain, United States Public Health Service, Acting Director, National Immunization Program, Centers for Disease Control and Prevention
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - McPherson, Merle
T1 - 2003 Job Lewis Smith Award Acceptance Address: Achieving the Unfinished Agenda Through Public--Private Partnerships.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/08//
VL - 114
IS - 2
M3 - Speech
SP - 474
EP - 476
PB - American Academy of Pediatrics
SN - 00314005
AB - Presents the text of a speech delivered by pediatrician Merle McPherson, fellow of the American Academy of Pediatrics, at the American Academy of Pediatrics convention. Career as a professional pediatrician; Effort to improve the services for children with special health care needs; Development of community-based systems of services for children and their family.
KW - PEDIATRICIANS
KW - CHILDREN -- Health
KW - PEDIATRICS
KW - MCPHERSON, Merle
N1 - Accession Number: 13854308; McPherson, Merle 1; Email Address: mmcpherson@hrsa.gov; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Service Administration, DHHS, Rockville, Maryland; Source Info: Aug2004, Vol. 114 Issue 2, p474; Subject Term: PEDIATRICIANS; Subject Term: CHILDREN -- Health; Subject Term: PEDIATRICS; People: MCPHERSON, Merle; Number of Pages: 3p; Document Type: Speech
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106627061
T1 - 2003 Job Lewis Smith award acceptance address: achieving the unfinished agenda through public-private partnerships.
AU - McPherson M
Y1 - 2004/08//
N1 - Accession Number: 106627061. Language: English. Entry Date: 20050425. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child, Disabled -- History
KW - Child, Disabled -- Legislation and Jurisprudence
KW - Child, Disabled
KW - Community Health Services -- Administration
KW - Community Health Services -- History
KW - American Academy of Pediatrics
KW - Awards and Honors
KW - Child
KW - Pediatrics
KW - Private Sector
KW - Public Sector
KW - United States
SP - 474
EP - 476
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 114
IS - 2
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Service Administration, DHHS, Rockville, Maryland mmcpherson@hrsa.gov
U2 - PMID: 15286233.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Flynn, Brian W.
AU - Norwood, Ann E.
T1 - Defining Normal Psychological Reactions to Disaster.
JO - Psychiatric Annals
JF - Psychiatric Annals
Y1 - 2004/08//
VL - 34
IS - 8
M3 - Article
SP - 597
EP - 603
PB - SLACK Incorporated
SN - 00485713
AB - The article identifies the normal phases of psychological reactions to disaster. It examines the different groups affected by disaster including primary victims and survivors. It offers an overview of psychiatric disorders associated with disasters such as post-traumatic stress disorder. It describes the basic assumptions and principles of the mental health response to disaster.
KW - DISASTERS -- Psychological aspects
KW - DISASTER victims -- Psychology
KW - MENTAL health
KW - POST-traumatic stress disorder
KW - MENTAL health services
N1 - Accession Number: 21439052; Flynn, Brian W. 1; Norwood, Ann E. 2; Source Information: Aug2004, Vol. 34 Issue 8, p597; Subject: DISASTERS -- Psychological aspects; Subject: DISASTER victims -- Psychology; Subject: MENTAL health; Subject: POST-traumatic stress disorder; Subject: MENTAL health services; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Reissman, Dori
AU - Klomp, Richard W.
AU - Kent, Adrian T.
AU - Pfefferbaum, Betty
T1 - Exploring Psychological Resilience in the Face Of Terrorism.
JO - Psychiatric Annals
JF - Psychiatric Annals
Y1 - 2004/08//
VL - 34
IS - 8
M3 - Article
SP - 626
EP - 632
PB - SLACK Incorporated
SN - 00485713
AB - The article examines psychological resilience in the aftermath of terrorist events. It defines the construct of psychological resilience and discusses the risk and protective factors that have been identified as capable of influencing individuals' resilience. It provides an overview of the adaptive processes associated with resilience in individuals.
KW - TERRORISM -- Psychological aspects
KW - RESILIENCE (Personality trait)
KW - PSYCHOLOGY
KW - PERSONALITY
KW - PERSONS
N1 - Accession Number: 21439061; Reissman, Dori 1,2; Klomp, Richard W. 3; Kent, Adrian T. 4; Pfefferbaum, Betty 5,6; Source Information: Aug2004, Vol. 34 Issue 8, p626; Subject: TERRORISM -- Psychological aspects; Subject: RESILIENCE (Personality trait); Subject: PSYCHOLOGY; Subject: PERSONALITY; Subject: PERSONS; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=21439061&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106627174
T1 - Growth of mental health services in state adult correctional facilities, 1988 to 2000.
AU - Manderscheide RW
AU - Gravesande A
AU - Goldstrom ID
Y1 - 2004/08//
N1 - Accession Number: 106627174. Language: English. Entry Date: 20050506. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Correctional Facilities
KW - Mental Disorders -- Therapy
KW - Mental Health Services -- Utilization -- United States
KW - Adult
KW - Descriptive Statistics
KW - Health Services Accessibility
KW - Mental Disorders -- Epidemiology
KW - Questionnaires
KW - Surveys
KW - United States
KW - Human
SP - 869
EP - 872
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 55
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: This study examined trends in the availability and use of mental health services in state adult correctional facilities. METHODS: Results from the 1988 Inventory of Mental Health Services in State Adult Correctional Facilities of the Center for Mental Health Services were compared with those from the 2000 Census of State and Federal Adult Correctional Facilities survey of the Bureau of Justice Statistics. The two surveys were chosen because they occurred more than a decade apart, had a reasonable amount of data, and could be made comparable. RESULTS: This analysis used data from 757 state adult correctional facilities that were sampled in 1988. The number of such facilities increased to 1,097 in 2000, a 44.9 percent increase. A dramatic increase was also seen in the prison population, from 505,712 in 1988 to 1,084,625 in 2000, a 114.5 percent increase. Mental health services were offered in significantly more facilities in 2000 than in 1988. However, the relative percentage of facilities that offered mental health services decreased overall. Simultaneously, the percentage of inmates who used these services increased overall. CONCLUSIONS: The growth in prison facilities and the growth in prisoner populations are outstripping the more meager growth in mental health services. These results suggest that mental health services are becoming less available to the prison population, and service populations are becoming more concentrated in the facilities that do offer such services.
SN - 1075-2730
AD - Division of State and Community Systems Development, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 15-C-04, Rockville, MD 20857; rmanders@samhsa.gov
U2 - PMID: 15292535.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106627174&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hawks, Catharine
AU - Makos, Kathryn
AU - Bell, Deborah
AU - Wambach, Paul F.
AU - Burroughs, G. Edward
T1 - An inexpensive method to test for mercury vapor in herbarium cabinets.
JO - Taxon
JF - Taxon
Y1 - 2004/08//
VL - 53
IS - 3
M3 - Article
SP - 783
EP - 790
SN - 00400262
AB - Mercuric chloride has been used for control of insect and fungal infestations in herbarium collections for over two centuries. One of the lasting effects of this use is the long-term evolution of elemental mercury vapor from treated specimens. The vapor can contaminate untreated specimens sharing the same closed environment and can pose a human health hazard. By modifying the technique for use of a commercially available mercury indicating powder (Mallinckrodt Baker, Inc., J. T. Baker Mercury Indicator) it is possible to create an inexpensive and fairly rapid test for mercury vapor in herbarium cabinets. The indicator is mixed with deionized water and applied to glass microscope slides. One or more slides are placed inside a cabinet and any color change in the indicator is compared to unexposed controls. In the authors' experiments, the indicator results were compared against readings taken using a Jerome 431-X Mercury Vapor Analyzer and a Lumex RA-915+ Multifunctional Mercury Analyzer and were found to be broadly related to the concentration of mercury vapor present in each cabinet. The method can be used to check for mercury contamination in incoming shipments of specimens and to identify cabinets that currently contain or formerly contained contaminated specimens. Practical safety guidelines have been developed for accessing cabinets that give a positive test for the vapor and for handling contaminated specimens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Taxon is the property of International Association for Plant Taxonomy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Herbaria
KW - Mercuric chloride
KW - Mercury compounds
KW - Botany
KW - Mercury vapor
KW - Botanical specimens
KW - corrosive sublimate
KW - herbaria
KW - mercuric chloride
KW - mercury contamination
KW - mercury detection
KW - mercury indicator
KW - mercury vapor
N1 - Accession Number: 14849898; Hawks, Catharine 1; Email Address: cahawks@aol.com; Makos, Kathryn 2; Email Address: makosk@si.edu; Bell, Deborah 3; Email Address: belLdeborah@nmnh.si.edu; Wambach, Paul F. 4; Email Address: paul.wambaeh@eh.doe.gov; Burroughs, G. Edward 5; Email Address: gebl@cdc.gov; Affiliations: 1: Conservator, 2419 Barbour Road, Falls Church, Virginia 22043, U.S.A; 2: Smithsonian Office of Safety and Environmental Management, 750 Ninth Street, Suite 9100, Washington, D.C. 20560, U.S.A; 3: Department of Systematic Biology-Botany Section, National Museum of Natural History, MRC 166, Smithsonian Institution, Washington, D.C. 20560, U.S.A; 4: U.S. Department of Energy, EH-53/270 Corporate Square Building 1000 Independence Avenue, SW, Washington, D. C. 20585, U.S.A.; 5: National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, Ohio 45226, U.S.A.; Issue Info: Aug2004, Vol. 53 Issue 3, p783; Thesaurus Term: Herbaria; Thesaurus Term: Mercuric chloride; Thesaurus Term: Mercury compounds; Thesaurus Term: Botany; Subject Term: Mercury vapor; Subject Term: Botanical specimens; Author-Supplied Keyword: corrosive sublimate; Author-Supplied Keyword: herbaria; Author-Supplied Keyword: mercuric chloride; Author-Supplied Keyword: mercury contamination; Author-Supplied Keyword: mercury detection; Author-Supplied Keyword: mercury indicator; Author-Supplied Keyword: mercury vapor; NAICS/Industry Codes: 712110 Museums; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Luster, Michael I.
AU - Simeonova, Petia P.
T1 - Arsenic and urinary bladder cell proliferation
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/08//
VL - 198
IS - 3
M3 - Article
SP - 419
EP - 423
SN - 0041008X
AB - Epidemiologic studies have demonstrated that a close association exists between the elevated levels of arsenic in drinking water and the incidence of certain cancers, including transitional cell carcinomas of the urinary bladder. We have employed in vitro and in vivo models to examine the effects of sodium arsenite on the urinary bladder epithelium. Mice exposed to 0.01% sodium arsenite in drinking water demonstrated hyperproliferation of the bladder uroepithelium within 4 weeks after initiating treatment. This occurred in the absence of amorphous precipitates and was accompanied by the accumulation of trivalent arsenite (iAs3+), and to a lesser extent dimethylarsenic (DMA), arsenate (iAs5+), and monomethylarsenic (MMA) in bladder tissue. In contrast to the bladder, urinary secretion was primarily in the form of DMA and MMA. Arsenic-induced cell proliferation in the bladder epithelium was correlated with activation of the MAP kinase pathway, leading to extracellular signal-regulated kinase (ERK) kinase activity, AP-1 activation, and expression of AP-1-associated genes involved in cell proliferation. Activation of the MAP kinase pathway involved both epidermal growth factor (EGF) receptor-dependent and -independent events, the latter involving Src activation. Studies summarized in this review suggest that arsenic accumulates in urinary bladder epithelium causing activation of specific signaling pathways that lead to chronic increased cell proliferation. This may play a non-epigenetic role in carcinogenesis by increasing the proliferation of initiated cells or increasing the mutational rate. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Arsenic
KW - Drinking water
KW - Urinary organs
KW - Epithelium
KW - Arsenic carcinogenesis
KW - Arsenic toxicity
KW - MAP kinase activation
KW - Transitional cell carcinomas
KW - Urinary bladder cancer
N1 - Accession Number: 13905988; Luster, Michael I.; Email Address: mluster@cdc.gov; Simeonova, Petia P. 1; Affiliations: 1: Inflammatory Disease Teams, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA; Issue Info: Aug2004, Vol. 198 Issue 3, p419; Thesaurus Term: Arsenic; Thesaurus Term: Drinking water; Subject Term: Urinary organs; Subject Term: Epithelium; Author-Supplied Keyword: Arsenic carcinogenesis; Author-Supplied Keyword: Arsenic toxicity; Author-Supplied Keyword: MAP kinase activation; Author-Supplied Keyword: Transitional cell carcinomas; Author-Supplied Keyword: Urinary bladder cancer; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.taap.2003.07.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=13905988&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simeonova, Petia P.
AU - Luster, Michael I.
T1 - Arsenic and atherosclerosis
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/08//
VL - 198
IS - 3
M3 - Article
SP - 444
EP - 449
SN - 0041008X
AB - Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitrogen compounds
KW - Arsenic
KW - Atherosclerosis
KW - Apolipoprotein E
KW - “blackfoot” disease (BFD)
KW - apolipoprotein E (ApoE)
KW - Arsenic toxicity
KW - Cardiovascular toxicity
KW - endothelial nitric oxide synthase (eNOS)
KW - Environmental factors
KW - human aortic endothelial cells (HAEC)
KW - Inflammation
KW - interleukin-8 (IL-8)
KW - low-density lipoprotein (LDL)
KW - monocyte chemoattractant protein (MCP-1)
KW - nitric oxide (NO)
KW - reactive oxygen species (ROS)
KW - vascular adhesion molecules (VCAM-1)
KW - Vascular diseases
N1 - Accession Number: 13905991; Simeonova, Petia P.; Email Address: psimeonova@cdc.gov; Luster, Michael I. 1; Affiliations: 1: Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA; Issue Info: Aug2004, Vol. 198 Issue 3, p444; Thesaurus Term: Nitrogen compounds; Thesaurus Term: Arsenic; Subject Term: Atherosclerosis; Subject Term: Apolipoprotein E; Author-Supplied Keyword: “blackfoot” disease (BFD); Author-Supplied Keyword: apolipoprotein E (ApoE); Author-Supplied Keyword: Arsenic toxicity; Author-Supplied Keyword: Cardiovascular toxicity; Author-Supplied Keyword: endothelial nitric oxide synthase (eNOS); Author-Supplied Keyword: Environmental factors; Author-Supplied Keyword: human aortic endothelial cells (HAEC); Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: interleukin-8 (IL-8); Author-Supplied Keyword: low-density lipoprotein (LDL); Author-Supplied Keyword: monocyte chemoattractant protein (MCP-1); Author-Supplied Keyword: nitric oxide (NO); Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: vascular adhesion molecules (VCAM-1); Author-Supplied Keyword: Vascular diseases; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.taap.2003.10.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=13905991&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Escalante, Ananias A.
AU - Cornejo, Omar E.
AU - Rojas, Ascanio
AU - Udhayakumar, Venkatachalam
AU - Lal, Altaf A.
T1 - Assessing the effect of natural selection in malaria parasites
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2004/08//
VL - 20
IS - 8
M3 - Article
SP - 388
EP - 395
SN - 14714922
AB - There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago. [Copyright &y& Elsevier]
AB - Copyright of Trends in Parasitology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITES
KW - NATURAL selection
KW - DRUG resistance
KW - GENETICS
KW - VACCINES
KW - ANTIGENS
N1 - Accession Number: 13701810; Escalante, Ananias A. 1,2; Email Address: Aescalante@cdc.gov Cornejo, Omar E. 1 Rojas, Ascanio 1 Udhayakumar, Venkatachalam 2 Lal, Altaf A. 2; Affiliation: 1: Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020-A, Venezuela 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Mail Stop F-12, 4770 Buford Highway, Chamblee, GA 30341, USA; Source Info: Aug2004, Vol. 20 Issue 8, p388; Subject Term: PARASITES; Subject Term: NATURAL selection; Subject Term: DRUG resistance; Subject Term: GENETICS; Subject Term: VACCINES; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.pt.2004.06.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13701810&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-17048-009
AN - 2004-17048-009
AU - Atkins, David
AU - Clancy, Carolyn
T1 - Multiple Risk Factors Interventions: Are We Up to the Challenge?
T3 - Addressing Multiple Behavioral Risk Factors in Primary Care
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2004/08//
VL - 27
IS - 2,Suppl
SP - 102
EP - 103
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Atkins, David, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2004-17048-009. PMID: 15275678 Partial author list: First Author & Affiliation: Atkins, David; Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20050321. Correction Date: 20160516. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Promotion; Lifestyle; Preventive Medicine; Risk Factors. Minor Descriptor: At Risk Populations; Intervention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Aug, 2004.
AB - Authors of the series of papers in this supplement to the 'American Journal of Preventive Medicine' argue that it is now time for both clinicians and researchers to adopt a more comprehensive and integrated approach to promoting healthier lifestyles in place of the current practice of addressing individual risk factors in isolation. The papers document the prevalence of the multiple risk factors, summarize what we know and still need to learn about how to identify and intervene against them, and suggest an agenda for moving research and policy forward. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventive medicine
KW - healthy lifestyle
KW - health promotion
KW - behavioral risk factors
KW - interventions
KW - at risk population
KW - 2004
KW - Health Promotion
KW - Lifestyle
KW - Preventive Medicine
KW - Risk Factors
KW - At Risk Populations
KW - Intervention
KW - 2004
DO - 10.1016/j.amepre.2004.04.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17048-009&site=ehost-live&scope=site
UR - datkins@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-16054-012
AN - 2004-16054-012
AU - Dixon, L.
AU - Lucksted, A.
AU - Stewart, B.
AU - Burland, J.
AU - Brown, C. H.
AU - Postrado, L.
AU - McGuire, C.
AU - Hoffman, M.
AU - Munk-Jørgensen, Povl
ED - Munk-Jørgensen, Povl
T1 - Erratum.
JF - Acta Psychiatrica Scandinavica
JO - Acta Psychiatrica Scandinavica
JA - Acta Psychiatr Scand
Y1 - 2004/08//
VL - 110
IS - 2
SP - 159
EP - 159
CY - United Kingdom
PB - Blackwell Publishing
SN - 0001-690X
SN - 1600-0447
AD - Dixon, L., University of Maryland School of Medicine, VA Capital Health Care Network MIRECC, 685 West Baltimore St MSTF/Room 300, Baltimore, MD, US, 21201
N1 - Accession Number: 2004-16054-012. Partial author list: First Author & Affiliation: Dixon, L.; Center for Mental Health Services Research, University of Maryland, Department of Psychiatry, School of Medicine, Baltimore, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050131. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Caregiver Burden; Educational Program Evaluation; Educational Programs; Family Members; Mental Disorders. Minor Descriptor: Mental Health Services; Self-Care Skills; Severity (Disorders). Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 1. Issue Publication Date: Aug, 2004.
AB - Reports an error in the original article by Dixon et al. (Acta Psychiatrica Scandinavica, 2004[Mar], Vol 109[3], 207-215). The article stated that Joyce Burland, the creator of the Family-to-Family Program, also created the Family Member Questionnaire for this research study. Fourteen of the 37 items of the Family Member Questionnaire are items of the Cook and Pickett Parental Burden Scale. (The following abstract of this article originally appeared in record [rid]2004-10668-007[/rid].) The Family-to-Family Education Program (FFEP) is a 12-week course for family members of adults with serious mental illness (SMI). This study evaluated the effectiveness of FFEP for several family member outcomes. The FFEP enrollees on a waiting list were eligible; 95 consenting family members agreed to four interviews (waitlist, pre- FFEP, post-FFEP, and 6 months post-FFEP) regarding subjective and objective burden, empowerment, and depression. Mixed effects ANOVA models tested hypotheses of decreased burden and increased empowerment after FFEP. The FFEP was associated with reduced subjective burden (P < 0.01) and increased empowerment (P < 0.01) without changes in objective burden. Knowledge about SMI, understanding the mental health system, and self-care also improved. There was no significant decay at 6-month followup. This study provides evidence that FFEP is helpful to relatives of persons with SMI by reducing subjective burden and worry, and increasing empowerment, knowledge about SMI, understanding the mental health system, and self-care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family education program
KW - program evaluation
KW - severe mental illness
KW - caregiver burden
KW - self care
KW - peer education
KW - 2004
KW - Caregiver Burden
KW - Educational Program Evaluation
KW - Educational Programs
KW - Family Members
KW - Mental Disorders
KW - Mental Health Services
KW - Self-Care Skills
KW - Severity (Disorders)
KW - 2004
DO - 10.1111/j.1600-0047.2004.00379.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-16054-012&site=ehost-live&scope=site
UR - ldixon@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19710-003
AN - 2004-19710-003
AU - Meyer, Jerrold S.
AU - Grande, Mark
AU - Johnson, Kenneth
AU - Ali, Syed F.
T1 - Neurotoxic effects of MDMA ('ecstasy') administration to neonatal rats.
T3 - Developmental aspects of addiction
JF - International Journal of Developmental Neuroscience
JO - International Journal of Developmental Neuroscience
JA - Int J Dev Neurosci
Y1 - 2004/08//Aug-Oct, 2004
VL - 22
IS - 5-6
SP - 261
EP - 271
CY - Netherlands
PB - Elsevier Science
SN - 0736-5748
AD - Meyer, Jerrold S., Department of Psychology, Neuroscience and Behavior Program, University of Massachusetts, Tobin Hall, 135 Hicks Way, Amherst, MA, US, 01003
N1 - Accession Number: 2004-19710-003. PMID: 15380826 Partial author list: First Author & Affiliation: Meyer, Jerrold S.; Department of Psychology, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA, US. Release Date: 20050228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hyperthermia; Methylenedioxymethamphetamine; Neonatal Period; Neurotoxicity; Rats. Minor Descriptor: Injections. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug-Oct, 2004.
AB - 3,4-Methylenedioxymethamphetamine damages fine serotonergic fibers and nerve terminals in adult organisms. Developing animals seem to be less susceptible to this effect, possibly due to a lack of drug-induced hyperthermia. We tested this hypothesis by producing hyperthermia in neonatal rats for 2h after each of twice-daily MDMA (l0mg/kg s.c.) or saline injections administered from postnatal days 1-4. Other drug-treated and control litters were maintained at normothermic temperatures following injection. Changes in forebrain serotonergic innervation were assessed at postnatal day 25 (serotonin transporter binding and serotonin levels), postnatal day 60 (serotonin transporter binding), and 9 months of age (serotonin transporter immunohistochemistry). We also determined the influence of MDMA treatment on apoptotic activity by means of immunohistochemistry for cleaved caspase-3 at postnatal day 5. The hippocampus showed significant MDMA-related reductions in serotonergic markers at postnatal day 25 and postnatal day 60. At 9 months, there was no effect of prior MDMA exposure on serotonin transporter-immunoreactive fiber density in the hippocampus; however, significant reductions in fiber density were observed in two neocortical areas and a hyperinnervation was found in the caudate-putamen and nucleus accumbens shell. MDMA treatment also produced a two-fold increase in the number of cleaved caspase-3-immunoreactive cells in the rostral forebrain and hippocampus. All of these effects were completely independent of pup body temperature. These findings demonstrate that neonatal MDMA administration exposure stimulates apoptotic cell death in various forebrain areas and also leads to a long-term reorganization of the forebrain serotonergic innervation. Consequently, offspring of MDMA-using women may be at heightened risk for abnormal neural and behavioral development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurotoxic effects
KW - methylenedioxymethamphetamine
KW - neonatal rats
KW - hyperthermia
KW - saline injections
KW - 2004
KW - Hyperthermia
KW - Methylenedioxymethamphetamine
KW - Neonatal Period
KW - Neurotoxicity
KW - Rats
KW - Injections
KW - 2004
DO - 10.1016/j.ijdevneu.2004.04.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19710-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-8382-7075
UR - jmeyer@psych.umass.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04256-001
AN - 2005-04256-001
AU - Ritchie, Elspeth Cameron
AU - Friedman, Matthew
AU - Watson, Patricia
AU - Ursano, Robert
AU - Wessely, Simon
AU - Flynn, Brian
T1 - Mass Violence and Early Mental Health Intervention: A Proposed Application of Best Practice Guidelines to Chemical, Biological, and Radiological Attacks.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2004/08//
VL - 169
IS - 8
SP - 575
EP - 579
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Ritchie, Elspeth Cameron, Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, US, 20814
N1 - Accession Number: 2005-04256-001. PMID: 15379065 Partial author list: First Author & Affiliation: Ritchie, Elspeth Cameron; Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, US. Release Date: 20050620. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Crisis Intervention Services; Early Intervention; Mental Health; Terrorism; Violence. Minor Descriptor: Chemicals; Emergency Preparedness; Best Practices. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: Aug, 2004.
AB - Based on past episodes, there will be psychological sequelae to chemical, biological, and radiological attacks. Some of the psychological morbidity should be able to be ameliorated through planning and appropriate early intervention. Key components of early intervention are illustrated following a hypothetical scenario of a bomb and anthrax threat near the Pentagon. Many of these components, such as monitoring clear, consistent messages about health risks, are provided by physicians or politicians, not mental health providers, but have a serious impact on the mental health of the population. We hope that this scenario and the principles of response will prove useful to planners of emergency preparedness and responders in the case of an actual attack. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - mass violence
KW - early mental health intervention
KW - best practice guidelines
KW - radiological attacks
KW - biological atacks
KW - chemical atacks
KW - emergency preparedness
KW - 2004
KW - Crisis Intervention Services
KW - Early Intervention
KW - Mental Health
KW - Terrorism
KW - Violence
KW - Chemicals
KW - Emergency Preparedness
KW - Best Practices
KW - 2004
DO - 10.7205/MILMED.169.8.575
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04256-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-17293-001
AN - 2004-17293-001
AU - Manderscheid, Ronald W.
AU - Gravesande, Aliya
AU - Goldstrom, Ingrid D.
T1 - Growth of Mental Health Services in State Adult Correctional Facilities, 1988 to 2000.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2004/08//
VL - 55
IS - 8
SP - 869
EP - 872
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Manderscheid, Ronald W., Division of State and Community Systems Development, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 15-C-04, Rockville, MD, US, 20857
N1 - Accession Number: 2004-17293-001. PMID: 15292535 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Manderscheid, Ronald W.; Division of State and Community Systems Development, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20040920. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Correctional Institutions; Health Care Delivery; Health Care Utilization; Mental Health Services. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Aug, 2004.
AB - Objective: This study examined trends in the availability and use of mental health services in state adult correctional facilities. Methods: Results from the 1988 Inventory of Mental Health Services in State Adult Correctional Facilities of the Center for Mental Health Services were compared with those from the 2000 Census of State and Federal Adult Correctional Facilities survey of the Bureau of Justice Statistics. The two surveys were chosen because they occurred more than a decade apart, had a reasonable amount of data, and could be made comparable. Results: This analysis used data from 757 state adult correctional facilities that were sampled in 1988. The number of such facilities increased to 1,097 in 2000, a 44.9 percent increase. A dramatic increase was also seen in the prison population, from 505,712 in 1988 to 1,084,625 in 2000, a 114.5 percent increase. Mental health services were offered in significantly more facilities in 2000 than in 1988. However, the relative percentage of facilities that offered mental health services decreased overall. Simultaneously, the percentage of inmates who used these services increased overall. Conclusions: The growth in prison facilities and the growth in prisoner populations are outstripping the more meager growth in mental health services. These results suggest that mental health services are becoming less available to the prison population, and service populations are becoming more concentrated in the facilities that do offer such services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - state adult correctional facilities
KW - care services usage
KW - 2004
KW - Correctional Institutions
KW - Health Care Delivery
KW - Health Care Utilization
KW - Mental Health Services
KW - 2004
DO - 10.1176/appi.ps.55.8.869
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-17293-001&site=ehost-live&scope=site
UR - rmanders@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18946-002
AN - 2004-18946-002
AU - Gfroerer, Joseph
AU - Epstein, Joan
AU - Wright, Doug
T1 - Estimating substance abuse treatment need by state.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2004/08//
VL - 99
IS - 8
SP - 938
EP - 939
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Gfroerer, Joseph, Office of Applied Studies, SAMHSA, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2004-18946-002. PMID: 15265089 Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Gfroerer, Joseph; Office of Applied Studies, SAMHSA, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20041012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Health Care Utilization; Regional Differences; Treatment Facilities. Minor Descriptor: Epidemiology; Needs. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Aug, 2004.
AB - Comments on an article by W. E. McAuliffe and R. Dunn (see record [rid]2004-18946-010[/rid]) on substance abuse treatment needs and access. SAMHSA (Substance Abuse and Mental Health Services Administration) and others have used a variety of methods over the past three decades to measure the scope of the substance abuse problem. These efforts have focused on national estimates of heroin addicts, cocaine abusers, and the overall population in need of treatment for any type of substance. A critical first step in assessing treatment need is to define it. SAMHSA uses the DSM-IV criteria for substance dependence or abuse, widely used by policymakers, treatment providers, and researchers. A hierarchical Bayes estimation method produces state level estimates from the National Survey on Drug Use and Health (NSDUH; formerly called the National Household Survey on Drug Abuse). The NSDUH method has several important properties that index methods do not, including the one proposed by authors. However, a drawback of this and other index methods is their lack of clarity on what they measure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse treatment
KW - treatment needs
KW - geographic distribution
KW - treatment access
KW - interstate variations
KW - 2004
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Utilization
KW - Regional Differences
KW - Treatment Facilities
KW - Epidemiology
KW - Needs
KW - 2004
DO - 10.1111/j.1360-0443.2004.00818.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18946-002&site=ehost-live&scope=site
UR - JGfroere@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gauthier, Anne K.
AU - Clancy, Carolyn M.
AD - Robert Wood Johnson Foundation
AD - US Department of Health and Human Services
T1 - Consumer-Driven Health Care--Beyond Rhetoric with Research and Experience
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/08/02/
VL - 39
IS - 4
SP - 1049
EP - 1054
SN - 00179124
N1 - Accession Number: 0750082; Keywords: Health Care; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200410
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Analysis of Health Care Markets I11
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0750082&site=ehost-live&scope=site
UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Garcia, N.
AU - Gil, E.
AU - Rodriguez, E.
AU - Cordoba, D.
AU - Cisneros, M.
AU - Barquero, M.
AU - de Paz, C.
AU - Sanchez, S.
T1 - HEALTH INEQUALITIES: MORTALITY IN VALLECAS.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2004/08/02/Aug2004 Supplement 1
VL - 58
M3 - Article
SP - A81
EP - A82
SN - 0143005X
AB - Mortality statistics are one of the major sources of information in the evaluation of the state of health of the population. The main objective of this study is to analyze pathologies causing excess mortality in Vallecas with respect to the community of Madrid. Cumulative deaths from 1994 to 1998 were analyzed, calculating the gross and specific mortality rates by cause and sex potential years of life loss. Results were compared with those of the community as a whole, by direct standardization and using the 1990 European population as a standard.
KW - MORTALITY
KW - POPULATION
KW - HEALTH
KW - PATHOLOGY
KW - MADRID (Spain)
KW - SPAIN
N1 - Accession Number: 14439027; Garcia, N. 1 Gil, E. 1 Rodriguez, E. 1 Cordoba, D. 1 Cisneros, M. 1 Barquero, M. 1 de Paz, C. 1 Sanchez, S. 1; Affiliation: 1: Regional Public Health Institute. Ministry of Health, Public Health Service Area, Community of Madrid, Spain.; Source Info: Aug2004 Supplement 1, Vol. 58, pA81; Subject Term: MORTALITY; Subject Term: POPULATION; Subject Term: HEALTH; Subject Term: PATHOLOGY; Subject Term: MADRID (Spain); Subject Term: SPAIN; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14439027&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neira, P.
AU - Rodriguez, E.
AU - Cisneros, M.
AU - Barquero, M.
AU - Iriso, A.
AU - Cobos, A.
T1 - COMPREHENSIVE PUBLIC HEALTH IMPROVEMENT PLAN FOR VALLECAS: A NEW EXPERIENCE WITH CITIZEN PARTICIPATION.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2004/08/02/Aug2004 Supplement 1
VL - 58
M3 - Article
SP - A106
EP - A106
SN - 0143005X
AB - In 2000, the government of the community of Madrid and the Vallecas Residents' Association agreed on an investment plan for this district of Madrid for the period 2001-2005, including financial provision, known as the Comprehensive Public Health Improvement Plan for Vallecas. The priority lines of action of the plan agreed on with the residents were established as follows: awareness of morbidity and mortality patterns; health promotion and health education programmes; and study and control of environmental and nutritional risk factors. The plan has resulted in: analysis of health related risk behaviour; identification and geo-referencing of environmental risk elements; qualitative research into the health needs perceived by the population and tuberculosis control by directly observed treatment.
KW - PUBLIC health administration
KW - HEALTH education
KW - HEALTH promotion
KW - PREVENTIVE health services
KW - NUTRITION -- Requirements
KW - TUBERCULOSIS
KW - MADRID (Spain)
KW - SPAIN
N1 - Accession Number: 14439116; Neira, P. 1 Rodriguez, E. 1 Cisneros, M. 1 Barquero, M. 1 Iriso, A. 2 Cobos, A. 1; Affiliation: 1: Public Health Institute Regional/Ministry of Health, Public Health Service Area 1, Community Madrid. Spain 2: Public Health Institute Regional Ministry of Health, Enronmental Health Service, Community Madrid. Spain; Source Info: Aug2004 Supplement 1, Vol. 58, pA106; Subject Term: PUBLIC health administration; Subject Term: HEALTH education; Subject Term: HEALTH promotion; Subject Term: PREVENTIVE health services; Subject Term: NUTRITION -- Requirements; Subject Term: TUBERCULOSIS; Subject Term: MADRID (Spain); Subject Term: SPAIN; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1/4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14439116&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Suleiman, O.H.
T1 - Radiation doses in pediatric radiology: influence of regulations and standards.
JO - Pediatric Radiology
JF - Pediatric Radiology
Y1 - 2004/08/02/Aug2004 Supplement 3
VL - 34
M3 - Article
SP - S242
EP - S246
SN - 03010449
AB - The benefits of x-ray examinations contribute to the quality of modern medicine; however the risk of using x-rays, a carcinogen, has always been a concern. This concern is heightened for pediatric patients, who have a much greater sensitivity to the carcinogenic effects of radiation than adults. The principle of as low as reasonably achievable, or ALARA, is essential for minimizing the radiation dose patients receive, especially for pediatric patients. In order to keep radiation doses ALARA, one must know the dose patients receive. The determination of radiation dose in a standard way is therefore necessary so that these doses can be compared with practice, and for meaningful comparison against voluntary standards. In extreme situations, where public health needs may require mandatory standards, or regulations, the quantitative measurement and calculation of radiation dose becomes essential. How some radiation dose metrics and standards have evolved, including the value of different metrics such as entrance air kerma, organ dose, and effective dose will be presented. Recent pediatric x-ray studies, whether or not dedicated pediatric equipment is necessary, and recent initiatives by the Food and Drug Administration for pediatric population will be discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Radiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION
KW - X-rays
KW - PEDIATRIC radiology
KW - MEDICAL radiology
KW - IMAGING systems
KW - JUVENILE diseases
KW - CANCER -- Risk factors
KW - Pediatrics
KW - Radiation dose
KW - Regulations
KW - Standards
N1 - Accession Number: 15399334; Suleiman, O.H. 1; Email Address: SuleimanO@cder.fda.gov; Affiliation: 1: Senior Science Policy Advisor, Food and Drug Administration (HFD-103), Center for Drug Evaluation and Research; Source Info: Aug2004 Supplement 3, Vol. 34, pS242; Subject Term: RADIATION; Subject Term: X-rays; Subject Term: PEDIATRIC radiology; Subject Term: MEDICAL radiology; Subject Term: IMAGING systems; Subject Term: JUVENILE diseases; Subject Term: CANCER -- Risk factors; Author-Supplied Keyword: Pediatrics; Author-Supplied Keyword: Radiation dose; Author-Supplied Keyword: Regulations; Author-Supplied Keyword: Standards; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/s00247-004-1276-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15399334&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Durand-Zaleski, Isabelle
AU - Bertrand, Michel
T1 - The Value of Clopidogrel versus Aspirin in Reducing Atherothrombotic Events: The CAPRIE Study.
JO - PharmacoEconomics
JF - PharmacoEconomics
Y1 - 2004/08/02/2004 Supplement 4
VL - 22
M3 - Article
SP - 19
EP - 27
PB - Springer Science & Business Media B.V.
SN - 11707690
AB - Atherothrombotic disease is a growing health problem, and is increasingly more costly to manage. Clopidogrel is an advanced, specific adenosine diphosphate receptor antagonist, which has been shown to be a highly potent antiplatelet agent. Data from the Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE) study have demonstrated the significantly superior clinical benefit of clopidogrel over aspirin for secondary prevention of atherothrombotic disease, with a relative risk reduction in myocardial infarction, stroke or vascular death of 8.7% (95% confidence interval 0.3, 16.5; P = 0.043). Moreover, clopidogrel demonstrated an amplified clinical benefit versus aspirin in patients at high risk of atherothrombotic events, such as those with a previous history of symptomatic atherothrombotic disease or with major risk factors such as diabetes mellitus or hypercholesterolaemia. On the basis of commonly accepted threshold criteria (e20 000 per life-year gained; LYG), clopidogrel in comparison with aspirin is cost-effective for the secondary prevention of atherothrombotic disease (cost per LYG ranging from e19 462 to e3256). Economic analyses have demonstrated consistent cost-effectiveness results with clopidogrel in different countries. Moreover, in high-risk patient subgroups the cost-effectiveness of clopidogrel in comparison with aspirin was even better (cost per LYG ranging from e5900 to e6310). Compared with other treatment strategies used for the prevention of ischaemic or atherothrombotic events, the cost-effectiveness of clopidogrel in comparison with aspirin based on CAPRIE is favourable, with most analyses in the intermediate range of cost-effectiveness. The available data thus support the use of clopidogrel as a clinically efficient and cost-effective option for secondary prevention of atherothrombotic disease, particularly in high-risk patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of PharmacoEconomics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALGESICS
KW - ISCHEMIA
KW - ASPIRIN
KW - CORONARY heart disease
KW - MYOCARDIAL infarction
KW - COST effectiveness
KW - EFFECTIVENESS
N1 - Accession Number: 15683579; Durand-Zaleski, Isabelle 1; Email Address: i.durand-zaleski@anaes.fr Bertrand, Michel 2; Affiliation: 1: Public Health Service, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France 2: Department of Cardiology, Hôpital Cardiologique, Lille, France; Source Info: 2004 Supplement 4, Vol. 22, p19; Subject Term: ANALGESICS; Subject Term: ISCHEMIA; Subject Term: ASPIRIN; Subject Term: CORONARY heart disease; Subject Term: MYOCARDIAL infarction; Subject Term: COST effectiveness; Subject Term: EFFECTIVENESS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15683579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kang, Ju-Hee
AU - Park, In-Sook
AU - Oh, Woo-Yong
AU - Lim, Hwa-Kyung
AU - Wang, So-Young
AU - Lee, Sung Yong
AU - Choi, Ki Hwan
AU - Kim, Joo-il
AU - Jung, Sang-Yong
AU - Suh, Chang Kook
AU - Kim, Dong Sup
T1 - Inhibition of aroclor 1254-induced depletion of stored calcium prevents the cell death in catecholaminergic cells
JO - Toxicology
JF - Toxicology
Y1 - 2004/08/05/
VL - 200
IS - 2/3
M3 - Article
SP - 93
EP - 101
SN - 0300483X
AB - The relationship between depleting effects of polychlorinated biphenyls (PCBs) on the intracellular calcium store and PCBs-induced cell death in dopaminergic cells has not been fully evaluated. Here, we evaluated the effects of inhibitors of the release of ER-stored calcium on the cytotoxicities induced by 10 μg/ml of Aroclor 1254 (A1254; polychlorinated biphenyl mixture) in a catecholaminergic cell-line, CATH.a cells. Exposure to A1254 produced an elevation in free calcium ([Ca2+]i) in the presence or absence of extracellular calcium and decreased in cell viability. From our results, we deduced that the A1254-induced elevation of [Ca2+]i resulted from the depletion of ER-stored calcium. The [Ca2+]i elevation was dramatically inhibited by an inositol 1,4,5-triphosphate receptor (IP3R) antagonist, and slightly inhibited by a ryanodine receptor (RyR) blocker. IP3R blockers conferred significant protection against A1254-induced cell death, as did RyR blockers, but calcium chelators or NMDA blockers did not. However, none of these reagents inhibited the depletion of intracellular dopamine by A1254 indicating that the mechanism of PCB-induced dopamine depletion may be independent of calcium alterations. Taken together, these data suggest that agents inhibiting the receptor-mediated depletion of stored calcium can prevent the A1254-induced cell death, but not modulate the A1254-induced intracellular dopamine depletion in CATH.a cells. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL death
KW - APOPTOSIS
KW - DOPAMINE
KW - CATECHOLAMINES
KW - Aroclor 1254
KW - Calcium
KW - CATH.a
KW - Cell death
KW - Dopamine
KW - ER depletion
N1 - Accession Number: 13470491; Kang, Ju-Hee 1 Park, In-Sook 2 Oh, Woo-Yong 2 Lim, Hwa-Kyung 2 Wang, So-Young 2 Lee, Sung Yong 2 Choi, Ki Hwan 2 Kim, Joo-il 2 Jung, Sang-Yong 3 Suh, Chang Kook 3 Kim, Dong Sup 2; Email Address: dskeem@kfda.go.kr; Affiliation: 1: Department of Pharmacology and Toxicology, College of Medicine, Inha University, Incheon 402-751, South Korea 2: Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyung-Gu, Seoul 122-704, South Korea 3: Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon 402-751, South Korea; Source Info: Aug2004, Vol. 200 Issue 2/3, p93; Subject Term: CELL death; Subject Term: APOPTOSIS; Subject Term: DOPAMINE; Subject Term: CATECHOLAMINES; Author-Supplied Keyword: Aroclor 1254; Author-Supplied Keyword: Calcium; Author-Supplied Keyword: CATH.a; Author-Supplied Keyword: Cell death; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: ER depletion; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2004.03.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13470491&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor
AU - Raiche, Joe
AU - Slovack, Mark
AU - Kovalchuk, Olga
T1 - Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2004/08/06/
VL - 320
IS - 4
M3 - Article
SP - 1253
EP - 1261
SN - 0006291X
AB - Radiation is a well-known genotoxic agent and human carcinogen that gives rise to a variety of long-term effects. Its detrimental influence on cellular function is actively studied nowadays. One of the most analyzed, yet least understood long-term effects of ionizing radiation is transgenerational genomic instability. The inheritance of genomic instability suggests the possible involvement of epigenetic mechanisms, such as changes of the methylation of cytosine residues located within CpG dinucleotides. In the current study we evaluated the dose-dependence of the radiation-induced global genome DNA methylation changes. We also analyzed the effects of acute and chronic high dose (5 Gy) exposure on DNA methylation in liver, spleen, and lung tissues of male and female mice and evaluated the possible persistence of the radiation-induced DNA methylation changes. Here we report that radiation-induced DNA methylation changes were sex- and tissue-specific, dose-dependent, and persistent. In parallel we have studied the levels of DNA damage in the exposed tissues. Based on the correlation between the levels of DNA methylation and DNA damage we propose that radiation-induced global genome DNA hypomethylation is DNA repair-related. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - GENES
KW - METHYLATION
KW - TISSUES
KW - DNA methylation
KW - DNA repair
KW - Epigenetics
KW - Genome instability
KW - Hypomethylation
KW - Ionizing radiation
N1 - Accession Number: 13705083; Pogribny, Igor 1 Raiche, Joe 2 Slovack, Mark 2 Kovalchuk, Olga 2; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada T1K 3M4; Source Info: Aug2004, Vol. 320 Issue 4, p1253; Subject Term: DNA; Subject Term: GENES; Subject Term: METHYLATION; Subject Term: TISSUES; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: DNA repair; Author-Supplied Keyword: Epigenetics; Author-Supplied Keyword: Genome instability; Author-Supplied Keyword: Hypomethylation; Author-Supplied Keyword: Ionizing radiation; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bbrc.2004.06.081
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=13705083&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Costamagna, P.
AU - Furst, K.
AU - Tully, K.
AU - Landis, J.
AU - Quach, L
AU - Kwak, J.
AU - Calvet, H.
AU - Lindsey, B.
AU - Flood, J
AU - Siegel, J.
AU - Winthrop, K.
AU - Jereb, J.
AU - Taylor, Z.
AU - Iademarco, M.
AU - Castro, K.
AU - Moser, K.
AU - Braun, M.
T1 - Tuberculosis Associated with Blocking Agents Against Tumor Necrosis Factor-Alpha -- California, 2002-2003.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/08/06/
VL - 53
IS - 30
M3 - Article
SP - 683
EP - 686
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Deals with the association of antagonists against tumor necrosis factor (TNF)-α with the tuberculosis (TB) disease according to the U.S. Food and Drug Administration. Effect of blocking TNF-α on TB; Overview of cases of TB occurring in association with infliximab therapy; Recommendations for TB prevention and treatment in patients administered or scheduled to receive TNF-α antagonists.
KW - TUMOR necrosis factor
KW - TUBERCULOSIS -- Prevention
KW - CHEMICAL inhibitors
KW - INFLIXIMAB
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 14329590; Costamagna, P. 1 Furst, K. 1 Tully, K. 1 Landis, J. 2 Quach, L 3 Kwak, J. 3 Calvet, H. 4 Lindsey, B. 4 Flood, J 5 Siegel, J. 6 Winthrop, K. 7 Jereb, J. 7 Taylor, Z. 7 Iademarco, M. 7 Castro, K. 7 Moser, K. 8 Braun, M. 9; Affiliation: 1: San Joaquin County Public Health Svcs 2: Santa Cruz County Health Svcs 3: County of Orange Health Care Agency 4: Long Beach City Dept of Health and Human Svcs 5: California Dept of Health Svcs 6: Center for Drug Evaluation and Research, Food and Drug Administration 7: Div of TB Elimination, National Center for HIV, STD, and TB Prevention, CDC 8: San Diego County Dept of Health 9: Center for Biologics Evaluation and Research; Source Info: 8/6/2004, Vol. 53 Issue 30, p683; Subject Term: TUMOR necrosis factor; Subject Term: TUBERCULOSIS -- Prevention; Subject Term: CHEMICAL inhibitors; Subject Term: INFLIXIMAB; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Lei
AU - Yan, Jian
AU - Wang, Shuguang
AU - Cohly, Hari
AU - Fu, Peter P.
AU - Hwang, Huey-Min
AU - Yu, Hongtao
T1 - Phototoxicity and DNA damage induced by the cosmetic ingredient chemical azulene in human Jurkat T-cells
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2004/08/08/
VL - 562
IS - 1/2
M3 - Article
SP - 143
EP - 150
SN - 13835718
AB - Previous study showed that the cosmetic ingredient chemical azulene and its derivative gauiazulene exhibited photomutagenicity four- to five-fold higher than spontaneous mutation in Salmonella typhimurium TA102. In this study, phototoxicity including photogenotoxicity of azulene in human Jurkat T-cells is reported. When the cell suspensions are irradiated by light (UVA plus visible light) in the presence of azulene, an azulene dose-dependent cellular DNA damage is observed. At the highest azulene concentration of 50 μM, the average DNA fragmentation is 33 ± 10%, determined by single cell gel electrophoresis (Comet assay). Cell viability assay using fluorescein diacetate indicates that the cells could endure the damage and remain viable. Further study revealed that the combination of light and azulene can cause single-strand cleavage on pure ΦX174 plasmid DNA in solution. Studies using scavengers reveal that singlet oxygen and free radicals are involved in causing DNA cleavage. This suggests that the photomutagenicity of azulene in S. typhimurium TA102 could be due to DNA fragmentation caused by the concurrent exposure to azulene and light. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Light
KW - DNA
KW - Cosmetics
KW - Cell suspensions
KW - Azulene
KW - Comet assay
KW - Cosmetic ingredient
KW - DNA cleavage
KW - Phototoxicity
N1 - Accession Number: 13905220; Wang, Lei 1; Yan, Jian 1; Wang, Shuguang 1; Cohly, Hari 2; Fu, Peter P. 3; Hwang, Huey-Min 4; Yu, Hongtao 1; Email Address: yu@ccaix.jsums.edu; Affiliations: 1: Department of Chemistry, Jackson State University, 1400 JR Lynch Street, Jackson, MS 39217, USA; 2: Department of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA; 3: National Center for Toxicological Research, Jefferson, AR 72709, USA; 4: Department of Biology, Jackson State University, Jackson, MS 39217, USA; Issue Info: Aug2004, Vol. 562 Issue 1/2, p143; Thesaurus Term: Light; Subject Term: DNA; Subject Term: Cosmetics; Subject Term: Cell suspensions; Author-Supplied Keyword: Azulene; Author-Supplied Keyword: Comet assay; Author-Supplied Keyword: Cosmetic ingredient; Author-Supplied Keyword: DNA cleavage; Author-Supplied Keyword: Phototoxicity; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrgentox.2004.06.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Giblin, Tara Bridget
AU - Sinkowitz-Cochran, Ronda L.
AU - Harris, Patricia L.
AU - Jacobs, Sharon
AU - Liberatore, Kathy
AU - Palfreyman, Marsha A.
AU - Harrison, Edward I.
AU - Denise M. Cardo
T1 - Clinicians' Perceptions of the Problem of Antimicrobial Resistance in Health Care Facilities.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2004/08/09/
VL - 164
IS - 15
M3 - Article
SP - 1662
EP - 1668
SN - 00039926
AB - Background Many clinicians do not comply with guidelines regarding antimicrobial resistance (AR). In response, the Centers for Disease Control and Prevention developed a national Campaign to Prevent Antimicrobial Resistance in Healthcare Settings that presents 4 strategies and 12 evidence-based steps. Methods To assess clinicians' perceptions of AR, barriers and facilitators to preventing AR, and how best to reach clinicians, a questionnaire and 4 focus groups were conducted after presentation of the Campaign at 4 Pittsburgh Regional Healthcare Initiative hospitals. Results One hundred seventeen clinicians completed the questionnaire; 28 participated in the focus groups. Clinicians were significantly more likely to perceive that AR was a problem nationally than in their own institution (95% vs 77%; P<.001) or practice (95% vs 65%; P = .002), consistent with focus group results (93% nationally vs 46% institution or practice). The 3 Campaign steps with the most barriers to implementation were "Treat infection, not colonization" (35%), "Stop treatment when infection is cured or unlikely" (35%), and "Practice antimicrobial control" (33%). Clinicians in the focus groups cited the additional barriers of the health care culture, lack of knowledge, and the nursing shortage; facilitators included education, information technology, and consults. Computer programs, posters, and local data were suggested for reaching clinicians about AR. Conclusions Clinicians perceive AR to be a complex national problem but less relevant to their own institution or practice. Providing clinicians with information and steps for preventing AR, as in the Campaign, may affect their perceptions of the problem and motivate them to take actions to ensure patient safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Internal Medicine is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG resistance in microorganisms
KW - EFFECT of drugs on microorganisms
KW - ANTI-infective agents
KW - HEALTH facilities
KW - MEDICAL personnel
KW - PUBLIC health
KW - Drug Resistance
KW - Evidence-Based Medicine
KW - Guidelines
N1 - Accession Number: 14069063; Giblin, Tara Bridget 1 Sinkowitz-Cochran, Ronda L. 1; Email Address: rls7@cdc.gov Harris, Patricia L. 2 Jacobs, Sharon 3 Liberatore, Kathy 4 Palfreyman, Marsha A. 5 Harrison, Edward I. 6 Denise M. Cardo 1; Affiliation: 1: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Ga 2: Department of Infection Control, the University of Pittsburgh Medical Center, Pittsburgh, PA 3: Department of Infection Control, St Clair Memorial Hospital, Pittsburgh, PA 4: Department of Infection Control, Monongahela Valley Hospital, Pittsburgh, PaDepartment of Infection Control, the Washington Hospital, Washington, Pa 5: Department of Infection Control, the Washington Hospital, Washington, Pa 6: Pittsburgh Regional Healthcare Initiative; Source Info: 8/9/2004, Vol. 164 Issue 15, p1662; Subject Term: DRUG resistance in microorganisms; Subject Term: EFFECT of drugs on microorganisms; Subject Term: ANTI-infective agents; Subject Term: HEALTH facilities; Subject Term: MEDICAL personnel; Subject Term: PUBLIC health; Author-Supplied Keyword: Drug Resistance; Author-Supplied Keyword: Evidence-Based Medicine; Author-Supplied Keyword: Guidelines; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106621202
T1 - Clinicians' perception of the problem of antimicrobial resistance in health care facilities.
AU - Giblin TB
AU - Sinkowitz-Cochran RL
AU - Harris PL
AU - Jacobs S
AU - Liberatore K
AU - Palfreyman MA
AU - Harrison EI
AU - Cardo DM
Y1 - 2004/08/09/
N1 - Accession Number: 106621202. Corporate Author: CDC (Centers for Disease Control and Prevention) Campaign to Prevent Antimicrobial Resistance Team. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Drug Resistance, Microbial
KW - Infection Control -- Standards
KW - Attitude of Health Personnel
KW - Staff Development
KW - Medical Staff, Hospital -- Psychosocial Factors
KW - Hospitals
KW - Pennsylvania
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Chi Square Test
KW - Questionnaires
KW - Focus Groups
KW - Human
SP - 1662
EP - 1668
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 164
IS - 15
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 15302636.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Young, John
AU - Tong, Weida
AU - Fang, Hong
AU - Xie, Qian
AU - Pearce>, Bruce
AU - Hashemi, Ray
AU - Beger, Richard
AU - Cheeseman, Mitchell
AU - Chen, James
AU - Chang, Yuan-chin
AU - Kodell, Ralph
T1 - BUILDING AN ORGAN-SPECIFIC CARCINOGENIC DATABASE FOR SAR ANALYSES.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/08/13/
VL - 67
IS - 17
M3 - Article
SP - 1363
EP - 1389
SN - 15287394
AB - FDA reviewers need a means to rapidly predict organ-specific carcinogenicity to aid in evaluating new chemicals submitted for approval. This research addressed the building of a database to use in developing a predictive model for such an application based on structure–activity relationships (SAR). The Internet availability of the Carcinogenic Potency Database (CPDB) provided a solid foundation on which to base such a model. The addition of molecular structures to the CPDB provided the extra ingredient necessary for SAR analyses. However, the CPDB had to be compressed from a multirecord to a single record per chemical database; multiple records representing each gender, species, route of administration, and organ-specific toxicity had to be summarized into a single record for each study. Multiple studies on a single chemical had to be further reduced based on a hierarchical scheme. Structural cleanup involved removal of all chemicals that would impede the accurate generation of SAR type descriptors from commercial software programs; that is, inorganic chemicals, mixtures, and organometallics were removed. Counterions such as Na, K, sulfates, hydrates, and salts were also removed for structural consistency. Structural modification sometimes resulted in duplicate records that also had to be reduced to a single record based on the hierarchical scheme. The modified database containing 999 chemicals was evaluated for liver-specific carcinogenicity using a variety of analysis techniques. These preliminary analyses all yielded approximately the same results with an overall predictability of about 63%, which was comprised of a sensitivity of about 30% and a specificity of about 77%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENICITY testing
KW - DATABASES
KW - COMPUTER software
KW - MEDICAL research
KW - CHEMICALS
KW - CHRONIC toxicity testing
N1 - Accession Number: 14167684; Young, John 1 Tong, Weida 1 Fang, Hong 2 Xie, Qian 2 Pearce>, Bruce 1 Hashemi, Ray 3 Beger, Richard 4 Cheeseman, Mitchell 5 Chen, James 1 Chang, Yuan-chin 6 Kodell, Ralph 1; Affiliation: 1: 1 Division of Biometry and Risk Assessment, Food and Drug Administration, National Center for Toxicological Research, Jefferson Arkansas USA 2: 2 Logicon ROW Sciences, Jefferson Arkansas USA 3: 3 Department of Computer Science, Armstrong Atlantic State University Savannah Georgia USA 4: 4 Division of Chemistry, Food and Drug Administration, National Center for Toxicological Research, Jefferson Arkansas, USA 5: 5 Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, Food andDrug Administration, College Park, Maryland USA 6: 6 Institute of Statistical Science, Academia Sinica, Taipei Taiwan; Source Info: 2004, Vol. 67 Issue 17, p1363; Subject Term: CARCINOGENICITY testing; Subject Term: DATABASES; Subject Term: COMPUTER software; Subject Term: MEDICAL research; Subject Term: CHEMICALS; Subject Term: CHRONIC toxicity testing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 27p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, H. W.
AU - Hu, S. Y.
AU - Barger, M. W.
AU - Ma, J. K. H.
AU - Castranova, V.
AU - Ma, J. Y. C.
T1 - TIME-DEPENDENT APOPTOSIS OF ALVEOLAR MACROPHAGES FROM RATS EXPOSED TO BLEOMYCIN: INVOLVEMENT OF TNF RECEPTOR 2.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2004/08/13/
VL - 67
IS - 17
M3 - Article
SP - 1391
EP - 1406
SN - 15287394
AB - Tumor necrosis factor-alpha (TNF-α) is produced by alveolar macrophages (AM) in response to bleomycin (BLM) exposure. This cytokine has been linked to BLM-induced pulmonary inflammation, an early drug effect, and to lung fibrosis, the ultimate toxic effect of BLM. The present study was carried out to study the time dependence of apoptotic signaling pathways and the potential roles of TNF receptors in BLM-induced AM apoptosis. Male Sprague-Dawley rats were exposed to saline or BLM (1 mg/kg) by intratracheal instillation. At 1, 3, or 7 d postexposure, AM were isolated by bronchoalveolar (BAL) lavage and evaluated for apoptosis by ELISA. The release of cytochrome c from mitochrondria, the activation of caspase-3, -8, and -9, the cleavage of nuclear poly(ADP-ribose) polymerase (PARP), and the expression of TNF receptors (TNF-R1/p55 and TNF-R2/p75), TNF-R-associated factor 2 (TRAF2), and cellular inhibitor of apoptosis 1 (c-IAP1) were determined by immunoblotting. The results showed that BLM exposure induced AM apoptosis, with the highest apoptotic effect occurring at 1 d after exposure and gradually decreasing at 3 and 7 d postexposure, but still remaining significantly above the control level. The maximal translocation of cytochromec from mitochondria into the cytosol was observed at 1 d postexposure, whereas the activation of caspase-9 and caspase-3 and caspase-3-dependent cleavage of PARP was found to reach a peak level at 3 d postexposure. BLM exposure had no marked effect on AM expression of TNF-R1 or caspase-8 activation, but significantly increased the expression of TNF-R2 that was accompanied by a rise in c-IAP1 and a decrease in TRAF2. This induction of TNF-R2 by BLM was significant on d 1 and increased with greater exposure time. In vitro studies showed that pretreatment of naive AM with a TNF-R2 antibody significantly inhibited BLM-induced caspase-3 activity and apoptosis. These results suggest that BLM-induced apoptosis involves multiple pathways in a time-dependent manner. Since maximal BLM-induced AM apoptosis (1 d postexposure) preceded maximal changes in caspase-9 and -3 (3 d postexposure), it is possible that a caspase-independent mechanism is involved in this initial response. These results indicate that the sustained expression of TNF-R2 in AM by BLM exposure may sensitize these cells to TNF-α-mediated toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - TUMOR necrosis factor
KW - APOPTOSIS
KW - BLEOMYCIN
KW - RATS as laboratory animals
KW - RETICULO-endothelial system
N1 - Accession Number: 14167682; Zhao, H. W. 1 Hu, S. Y. 2 Barger, M. W. 1 Ma, J. K. H. 1 Castranova, V. 1 Ma, J. Y. C. 1; Affiliation: 1: 1 Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown West Virginia USA 2: 2 School of Pharmacy, West Virginia University Morgantown West Virginia USA; Source Info: 2004, Vol. 67 Issue 17, p1391; Subject Term: MACROPHAGES; Subject Term: TUMOR necrosis factor; Subject Term: APOPTOSIS; Subject Term: BLEOMYCIN; Subject Term: RATS as laboratory animals; Subject Term: RETICULO-endothelial system; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hunter, Paul R.
AU - Hughes, Sara
AU - Woodhouse, Sarah
AU - Raj, Nicholas
AU - Syed, Qutub
AU - Chalmers, Rachel M.
AU - Verlander, Neville Q.
AU - Goodacre, John
T1 - Health Sequelae of Human Cryptosporidiosis in Immunocompetent Patients.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/08/15/
VL - 39
IS - 4
M3 - Article
SP - 504
EP - 510
SN - 10584838
AB - Background. There have been no systematic studies following up the longer term health effects of cases of cryptosporidliosis for which genotype data exist. Methods. We report a follow-up study of cases of laboratory-confirmed cryptosporidiosis. Case patients were sent a postal questionnaire asking about a wide range of symptoms occurring within 2 months after their initial diagnosis, and control subjects were sent the questionnaire 2 months after they had been recruited to the original study. Results. Completed questionnaires were received from 235 case patients and 232 control subjects. For 111 of the case patients, the species of the infecting strain was known; 61 of these strains were Cryptosporidium hominis (human genotype), and 50 were Cryptosporidium parvum (bovine genotype). Forty percent of the case patients reported recurrence of intestinal symptoms after resolution of the acute stage of illness, irrespective of whether infection was with C. hominis or C. parvum . Reports of joint pain (odds ratio [OR], 2.8), eye pains (OR, 2.44), recurrent headache (OR, 2.10), dizzy spells (OR, 1.69), and fatigue (OR, 3.0) were significantly more common in case patients than in control subjects, but only in people who had experienced C. hominis infection, Joint symptoms experienced by case patients were of longer duration than those experienced by control subjects. Conclusions. Our results confirm previous reports of a high rate of relapse of gastrointestinal symptoms following recovery from an acute episode of cryptosporidiosis and show that C. ho minis but not C. parvum is associated with an increased risk of nonintestinal sequelae. This study demonstrates that the impact of cryptosporidiosis on public health extends beyond that of the acute diarrheal illness and can lead to significant health sequelae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryptosporidiosis
KW - Public health
KW - Disease complications
KW - Genetic research
KW - Symptoms
KW - Patients
N1 - Accession Number: 14048052; Hunter, Paul R. 1; Email Address: paul.hunter@uea.ac.uk; Hughes, Sara 2; Woodhouse, Sarah 2; Raj, Nicholas 3; Syed, Qutub 2; Chalmers, Rachel M. 4; Verlander, Neville Q. 5; Goodacre, John 6; Affiliations: 1: School of Medicine, Health Policy and Practice, University of East Anglia, Norwich.; 2: Health Protection Agency-North West, Vernon Prichard Court, Chester.; 3: Department of Rheumatology, City Hospital, Nottingham.; 4: Health Protection Agency Cryptosporidium Reference Unit, National Public Health Service Microbiology Swansea, Singleton Hospital, Swansea.; 5: Statistics Unit, Health Protection Agency, Communicable Disease Surveillance Centre, London.; 6: Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, United Kingom.; Issue Info: 8/15/2004, Vol. 39 Issue 4, p504; Thesaurus Term: Cryptosporidiosis; Thesaurus Term: Public health; Subject Term: Disease complications; Subject Term: Genetic research; Subject Term: Symptoms; Subject Term: Patients; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hampshire, Victoria A.
AU - Doddy, Frederick M.
AU - Post, Lynn O.
AU - Koogler, Teresa L.
AU - Burgess, Tina M.
AU - Batten, Priscilla O.
AU - Hudson, Roderick
AU - McAdams, Dorothy R.
AU - Brown, Margarita A.
T1 - Adverse drug event reports at the United States Food and Drug Administration Center for Veterinary Medicine.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2004/08/15/
VL - 225
IS - 4
M3 - Article
SP - 533
EP - 536
SN - 00031488
AB - Explains to veterinarians the adverse drug event (ADE) reporting system in the United States and illustrates why reporting ADEs is ultimately helpful in updating labeled safety information. Blindness associated with high doses of enrofloxin in cats; Overdoses of moxidectin in horses associated with failure of a syringe-locking device; Keratoconjunctivitis sicca associated with etodolac in dogs.
KW - DRUGS -- Side effects
KW - VETERINARY drugs
KW - VETERINARY prescriptions
KW - VETERINARIANS
KW - ANIMAL specialists
KW - VETERINARY medicine
KW - UNITED States
N1 - Accession Number: 14362338; Hampshire, Victoria A. 1 Doddy, Frederick M. 1 Post, Lynn O. 1 Koogler, Teresa L. 1 Burgess, Tina M. 1 Batten, Priscilla O. 1 Hudson, Roderick 1 McAdams, Dorothy R. 1 Brown, Margarita A. 1; Affiliation: 1: United States Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish PI, Rockville, MD 20885; Source Info: 8/15/2004, Vol. 225 Issue 4, p533; Subject Term: DRUGS -- Side effects; Subject Term: VETERINARY drugs; Subject Term: VETERINARY prescriptions; Subject Term: VETERINARIANS; Subject Term: ANIMAL specialists; Subject Term: VETERINARY medicine; Subject Term: UNITED States; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106580457
T1 - The safety and availability of blood and tissues -- progress and challenges.
AU - Goodman JL
Y1 - 2004/08/19/
N1 - Accession Number: 106580457. Language: English. Entry Date: 20050211. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: Stramer SL, Glynn SA, Kleinman SH, Strong DM, Caglioti S, Wright DJ, et al. Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing. (N ENGL J MED) 8/19/2004; 351 (8): 760-844. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Blood Donors
KW - Bloodborne Pathogens
KW - Transplant Donors
KW - Virus Diseases -- Diagnosis
KW - Virus Diseases -- Transmission
KW - Blood Banks -- Standards
KW - Hepatitis C -- Transmission
KW - HIV Infections -- Transmission
KW - Nucleic Acid Amplification Techniques
KW - Tissue Banks -- Standards
SP - 819
EP - 822
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 351
IS - 8
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 15317896.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Andreishcheva, Ekaterina N.
AU - Kunkel, Jeremy P.
AU - Gemmill, Trent R.
AU - Trimble, Robert B.
T1 - Five Genes Involved in Biosynthesis of the Pyruvylated Ga1β1,3-Epitope in Schizosaccharomyces pombe N-Linked Glycans.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/08/20/
VL - 279
IS - 34
M3 - Article
SP - 35644
EP - 35655
SN - 00219258
AB - The N-linked galactomannans of Schizosaccharomyces pombe have pyruvylated Galβ1,3- (PvGal) caps on a portion of the Galα1,2-residues in their outer chains (Gemmill, T. R., and Trimble, R. B. (1998) Glycobiology 8, 1087–1095). PvGal biosynthesis was investigated by ethyl methanesulfonate mutagenesis of S. pombe, followed by the isolation of cells devoid of negatively charged N-glycans by Q-Sepharose exclusion and failure to bind human serum amyloid P component, which acts as a lectin for terminal PvGal residues. Mutant glycans were characterized by lectin binding, saccharide composition, exoglycosidase sensitivity, and NMR spectroscopy. Restoration of the cell surface negative charge by complementation with an S. pombe genomic library led to the identification of five genes involved in PvGal biosynthesis, which we designated pvg1-pvg5. Pvg1p may be a pyruvyltransferase, since NMR of pvg1- mutant N-glycans revealed the absence of only the pyruvyl moiety. Pvg2p-Pvg5p are crucial for attachment of the Galβ1,3- residue that becomes pyruvylated. Pvg3p is predicted to be a member of the β1,3-galactosyltransferase family, and Pvg3p-green fluorescent protein labeling was consistent with Golgi localization. Predicted Pvg1p and Pvg3p functions imply that Galβ1,3- is added to the galactomannans and is then pyruvylated in situ, rather than by an en bloc addition of PvGalβ1,3- caps to the outer chain. Pvg4p-green fluorescent protein targeted to the nucleus, and its sequence contains a MADS-box DNA-binding and dimerization domain; however, it does not appear to solely control transcription of the other identified genes. Pvg2p and/or Pvg5p may contribute to an enzyme complex. Whereas a functional role for the PvGal epitope in S. pombe remains unclear, it is nonessential for either cell growth or mating under laboratory conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMISTRY
KW - GENES
KW - ORGANIC synthesis (Chemistry)
KW - GREEN fluorescent protein
KW - MUTATION (Biology)
KW - TERATOGENESIS
KW - BLOOD plasma
KW - CELL membranes
N1 - Accession Number: 14464767; Andreishcheva, Ekaterina N. 1,2 Kunkel, Jeremy P. 1 Gemmill, Trent R. 1 Trimble, Robert B. 1,3; Email Address: trimble@wadsworth.org; Affiliation: 1: Wadsworth Center, New York State Department of Health, Albany, New York 12201-0509 2: Laboratory of Bacterial Toxins, Center for Biologics Evaluation and Research, Federal Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892 3: Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, New York 12201; Source Info: 8/20/2004, Vol. 279 Issue 34, p35644; Subject Term: BIOCHEMISTRY; Subject Term: GENES; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: GREEN fluorescent protein; Subject Term: MUTATION (Biology); Subject Term: TERATOGENESIS; Subject Term: BLOOD plasma; Subject Term: CELL membranes; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 12p; Illustrations: 8 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1074/jbc.M403574200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Bean T.
AU - Feather, Gregory A.
AU - Maynard, Andrew
AU - Rao, Carol Y.
T1 - Development of a Personal Sampler for Collecting Fungal Spores.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2004/09//
VL - 38
IS - 9
M3 - Article
SP - 926
EP - 937
SN - 02786826
AB - Exposure to fungal aerosols is of concern in indoor environments. However, sampling limitations have previously made it difficult to assess exposures accurately, especially long-term exposures. A prototype personal aerosol sampler, based on cyclone principles and using a 1.5 ml microcentrifuge tube as a particle collection receptacle has been designed and fabricated. Collection efficiency for aerosol particles in the size range of fungal spores has been evaluated for different types of microcentrifuge tubes, together with the effect of a polyethylene glycol coating on the inside of the tube and the effect of adding water to the tube. Monodisperse, fluorescently tagged polymer microspheres with median diameters of 0.5, 1, 2, 3, 6, 11, and 16 µm were used to evaluate sampler performance with particle diameter. The microcentrifuge-tube sampler was tested at flow rates of 2 and 4 liters per minute (l/min). Experimental results indicate that the microcentrifuge-tube sampler has an aspiration efficiency of 100% in calm air for particles up to 16 µm. At 4 l/min, the microcentrifuge-tube sampler is able to collect nearly 100% of particles greater than 3 ìm and >90% of particles between 2.5 and 3 µm. The 50% cutoff size is 1.5 µm. The performance of the sampler did not vary with the different brands of tubes tested or with the presence or absence of a coating on the tube surface. Furthermore, the addition of water to the tube resulted in a slight increase in collection efficiency. A sampling time of 5 h was feasible at 45-50% relative humidity before evaporation led to significant water loss. The cutoff size of 1.5 ìm is comparable to many commercially available bioaerosol samplers. Besides being easy to use, simple to fabricate, and inexpensive, this novel sampler has several advantages over conventional samplers: long-term samples are possible (the limitation of impaction methods); there is no sample transfer loss since the transfer step has been eliminated (the limitation of filter cassettes); laboratory analyses are not dependent solely upon a single analysis method (the limitation of impaction methods), and there is no sampler adherence loss (the limitation of trying to wash microorganisms from filters). In addition, use of the sampler would be applicable in a variety of occupational settings from low bioaerosol concentrations (i.e., indoor environments) to high bioaerosol concentrations (i.e., agricultural setting) by varying sampling time periods and using sensitive analytical methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FUNGAL spores
KW - AEROSOLS (Sprays)
KW - PARTICLES
KW - CENTRIFUGES
KW - SCIENTIFIC apparatus & instruments
N1 - Accession Number: 51876621; Chen, Bean T. 1; Email Address: bdc4@cdc.gov Feather, Gregory A. 1 Maynard, Andrew 2 Rao, Carol Y. 3; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, West Virginia 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, West Virginia 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, West Virginia; Source Info: Sep2004, Vol. 38 Issue 9, p926; Subject Term: FUNGAL spores; Subject Term: AEROSOLS (Sprays); Subject Term: PARTICLES; Subject Term: CENTRIFUGES; Subject Term: SCIENTIFIC apparatus & instruments; NAICS/Industry Codes: 333999 All Other Miscellaneous General Purpose Machinery Manufacturing; NAICS/Industry Codes: 333990 All other general-purpose machinery manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Shelagh
AU - Glik, Deborah
T1 - Evaluating Health Promotion Programs.
JO - American Journal of Health Behavior
JF - American Journal of Health Behavior
Y1 - 2004/09//Sep/Oct2004
VL - 28
IS - 5
M3 - Book Review
SP - 475
EP - 477
SN - 10873244
AB - Reviews the book "Evaluating Health Promotion Programs," by Thomas W. Valente.
KW - HEALTH promotion
KW - NONFICTION
KW - VALENTE, Thomas W.
KW - EVALUATING Health Promotion Programs (Book)
N1 - Accession Number: 16729669; Smith, Shelagh 1; Email Address: ssmith@samhsa.gov Glik, Deborah 2; Email Address: dglik@ucla.edu; Affiliation: 1: Public Health Advisor, Center for Mental Health Services, Substance Abuse & Mental Health Services Administration (SAMHSA), 5600 Fishers Lane, Rom 15-87, Rockville, MD. 2: Professor, UCLA School of Public Health, PO Box 951772, Los Angeles, CA 90095-1722.; Source Info: Sep/Oct2004, Vol. 28 Issue 5, p475; Subject Term: HEALTH promotion; Subject Term: NONFICTION; Reviews & Products: EVALUATING Health Promotion Programs (Book); People: VALENTE, Thomas W.; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106653460
T1 - First, do no harm: the perils of shift work.
AU - Hughes R
AU - Stone P
Y1 - 2004/09//
N1 - Accession Number: 106653460. Language: English. Entry Date: 20041022. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; pictorial; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Occupational Health
KW - Shift Workers
KW - Shiftwork
KW - Circadian Rhythm
KW - Education, Continuing (Credit)
KW - Fatigue -- Etiology
KW - Job Performance
KW - Nurses
KW - Sleep Deprivation -- Etiology
SP - 60
EP - 64
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 104
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Evening shift, night shift, and rotating shifts: are they for you?
SN - 0002-936X
AD - Senior Advisor on End-of-Life Care and Senior Health Scientist Administrator, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality
U2 - PMID: 15365343.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106653460&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goswami, Biswendu B.
AU - Kulka, Michael
AU - Ngo, Diana
AU - Cebula, Thomas A.
T1 - Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2′–5′ oligoadenylate synthetase
JO - Antiviral Research
JF - Antiviral Research
Y1 - 2004/09//
VL - 63
IS - 3
M3 - Article
SP - 153
EP - 166
SN - 01663542
AB - We have presented previously evidence that the cytopathogenic 18f strain of hepatitis A virus (HAV) induced degradation of ribosomal RNA (rRNA) in infected cells [Arch. Virol. 148 (2003) 1275–1300]. In contrast, the non-cytopathogenic parent virus HM175 clone 1 had no effect on rRNA integrity. We present here data showing that rRNA degradation is followed by apoptosis accompanied by characteristic DNA laddering in the cytoplasm of 18f infected cells. The DNA laddering coincided with the detection of caspase 3 and PARP-1 cleavage and was dependent upon activation of the caspase pathway, since treatment with Z-VAD-FMK, a pan-caspase inhibitor, inhibited both events. RNase L mRNA was present in both virus-infected and uninfected cells. Messenger RNA for the interferon inducible enzyme 2′–5′ oligoadenylate synthetase (2′–5′ OAS), which polymerizes ATP into 2′–5′ oligo adenylate (2–5A, the activator of RNase L) in the presence of double-stranded RNA, was not detected following virus infection. 2′–5′ OAS mRNA was induced by treatment of the cells with interferon-β (IFN-β). IFN-β mRNA was marginally induced following infection. However, phosphorylated STAT 1, a key regulator of interferon-stimulated gene transcription was not detected in virus infected cells. STAT 1 phosphorylation in response to IFN treatment was lower in virus-infected cells, compared to uninfected cells treated with interferon, suggesting that 18f virus infection interferes with interferon signaling. The results suggest that 18f infection causes the induction of a 2–5A independent RNase L like activity. [Copyright &y& Elsevier]
AB - Copyright of Antiviral Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - HEPATITIS A virus
KW - RNA
KW - OLIGOADENYLATES
KW - Apoptosis
KW - Caspase
KW - Hepatitis A virus
KW - RNA degradation
N1 - Accession Number: 14513268; Goswami, Biswendu B.; Email Address: bgoswami@cfsan.fda.gov Kulka, Michael 1 Ngo, Diana 1 Cebula, Thomas A. 1; Affiliation: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Food and Drug Administration, HFS-025, OARSA, FDA, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Sep2004, Vol. 63 Issue 3, p153; Subject Term: APOPTOSIS; Subject Term: HEPATITIS A virus; Subject Term: RNA; Subject Term: OLIGOADENYLATES; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Caspase; Author-Supplied Keyword: Hepatitis A virus; Author-Supplied Keyword: RNA degradation; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.antiviral.2004.02.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106530048
T1 - Prevalence and characteristics of children with special health care needs.
AU - van Dyck PC
AU - Kogan MD
AU - McPherson MG
AU - Weissman GR
AU - Newacheck PW
Y1 - 2004/09//
N1 - Accession Number: 106530048. Language: English. Entry Date: 20051021. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9422751.
KW - Child Health Services -- Evaluation
KW - Health Services Needs and Demand -- Evaluation -- In Infancy and Childhood
KW - Adolescence
KW - Age Factors
KW - Blacks
KW - Child
KW - Child, Disabled
KW - Child, Preschool
KW - Confidence Intervals
KW - Consumer Satisfaction
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Health Services Accessibility
KW - Hispanics
KW - Infant
KW - Infant, Newborn
KW - Interviews
KW - Male
KW - Multiple Logistic Regression
KW - Needs Assessment
KW - Odds Ratio
KW - Race Factors
KW - Socioeconomic Factors
KW - Survey Research
KW - United States
KW - Whites
KW - Human
SP - 884
EP - 890
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 158
IS - 9
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md
U2 - PMID: 15351754.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106530048&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Delongchamp, Robert R.
AU - Bowyer, John F.
AU - Chen, James J.
AU - Kodell, Ralph L.
T1 - Multiple-Testing Strategy for Analyzing cDNA Array Data on Gene Expression.
JO - Biometrics
JF - Biometrics
Y1 - 2004/09//
VL - 60
IS - 3
M3 - Article
SP - 774
EP - 782
PB - Wiley-Blackwell
SN - 0006341X
AB - An objective of many functional genomics studies is to estimate treatment-induced changes in gene expression. cDNA arrays interrogate each tissue sample for the levels of mRNA for hundreds to tens of thousands of genes, and the use of this technology leads to a multitude of treatment contrasts. By-gene hypotheses tests evaluate the evidence supporting no effect, but selecting a significance level requires dealing with the multitude of comparisons. The p-values from these tests order the genes such that a p-value cutoff divides the genes into two sets. Ideally one set would contain the affected genes and the other would contain the unaffected genes. However, the set of genes selected as affected will have false positives, i.e., genes that are not affected by treatment. Likewise, the other set of genes, selected as unaffected, will contain false negatives, i.e., genes that are affected. A plot of the observed p-values versus their expectation under a uniform [0, 1] distribution allows one to estimate the number of true null hypotheses. With this estimate, the false positive rates and false negative rates associated with any p-value cutoff can be estimated. When computed for a range of cutoffs, these rates summarize the ability of the study to resolve effects. In our work, we are more interested in selecting most of the affected genes rather than protecting against a few false positives. An optimum cutoff, i.e., the best set given the data, depends upon the relative cost of falsely classifying a gene as affected versus the cost of falsely classifying a gene as unaffected. We select the cutoff by a decision-theoretic method analogous to methods developed for receiver operating characteristic curves. In addition, we estimate the false discovery rate and the false nondiscovery rate associated with any cutoff value. Two functional genomics studies that were designed to assess a treatment effect are used to illustrate how the methods allowed the investigators to determine a cutoff to suit their research goals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biometrics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL decision making
KW - MATHEMATICAL models
KW - DNA microarrays
KW - GENE expression
KW - MESSENGER RNA
KW - GENOMICS
KW - BIOMETRY
KW - MEDICAL statistics
N1 - Accession Number: 14236198; Delongchamp, Robert R. 1; Email Address: rdelongchamp@nctr.fda.gov Bowyer, John F. 2 Chen, James J. 1 Kodell, Ralph L. 1; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079,fU.S.A. 2: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, U.S.A.; Source Info: Sep2004, Vol. 60 Issue 3, p774; Subject Term: STATISTICAL decision making; Subject Term: MATHEMATICAL models; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: MESSENGER RNA; Subject Term: GENOMICS; Subject Term: BIOMETRY; Subject Term: MEDICAL statistics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.0006-341X.2004.00228.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14236198&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106514593
T1 - Long-term care counselor: an electronic decision-support tool.
AU - Polniaszek S
AU - Klinger C
Y1 - 2004///Fall2004
N1 - Accession Number: 106514593. Language: English. Entry Date: 20050916. Revision Date: 20150820. Publication Type: Journal Article; case study; tables/charts; website. Journal Subset: Nursing; Peer Reviewed; USA. NLM UID: 100888264.
KW - Counseling
KW - Decision Making, Family
KW - Health Services for the Aged
KW - Long Term Care -- In Old Age
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Child
KW - Child, Preschool
KW - Housing for the Elderly
KW - Information Resources
KW - Long Term Care -- Economics
KW - Medicaid
KW - Medicare
KW - Middle Age
KW - Population
KW - United States
SP - 139
EP - 144
JO - Care Management Journals
JF - Care Management Journals
JA - CARE MANAGE J
VL - 5
IS - 3
CY - New York, New York
PB - Springer Publishing Company, Inc.
AB - With the Amrican population aging at a steady pace, the need to help individuals, families, and aging/health care professionals in making often-difficult long-term care decisions is increasing. Finding accurate, impartial information is also critically important, especially information that is personalized to the individual rather than for the general public. The Long-Term Care Counselor (LTCC) is a free and confidential, web-based, decision-support tool developed by The National Council on Aging (NCOA) to meet this particular need. It is part of the Centers for Medicare and Medicaid Service's (CMS) long-term care information initiative and is found via the official Medicare website at http://www.medicare.gov/longtermcare/ static/ltccounselor.asp. The LTCC helps individuals, caregivers, and professionals to find information relevant to particular circumstances based on the age, health, level of activity, finances, or personal preferences of the person.
SN - 1521-0987
AD - Project Director for the CMS Long-Term Care Counselor/Vice President for Long-Term Care, National Council on Aging (NCOA); susan.polniaszek@hhs.gov
U2 - PMID: 16149251.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106514593&site=ehost-live&scope=site
UR - Related websites: www.medicare.gov/longtermcare/static/ltccounselor.asp
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sue-Jane Wang
AU - Nevius, S. Edward
T1 - On the Commonly Used Design and Statistical Considerations in Double Blind, Potentially Unblind, and Open-Label Clinical Trials.
JO - Clinical Research & Regulatory Affairs
JF - Clinical Research & Regulatory Affairs
Y1 - 2004/09//
VL - 21
IS - 3/4
M3 - Article
SP - 213
EP - 229
PB - Taylor & Francis Ltd
SN - 10601333
AB - In clinical trials, parallel group designs, such as placebo-controlled trials or activecontrolled trials, are commonly used. The study design in comparative clinical trials to address the intended objective is vital to the interpretation of the trial results. If inappropriate study design are employed, they not only cannot answer the intended clinical hypothesis, but they can also impose adverse effects on the collection of efficacy and safety data that may further be compounded by observable and unobservable baseline data. Documentation and interpretation of the outcomes need to be carefully considered. It is well known that various sources of biases can arise during the course of the trial, for instance, design bias, operational bias, analytical bias, methodological bias, interpretation bias, and documentation bias. As a result of such biases, the accuracy and precision of the treatment effect estimate may be severely compromised, depending on the design considered. In this article, commonly used study designs for comparative clinical trials are described. Statistical considerations with various designs, the concept of robustness of statistical findings, and statistical evidence will be discussed in light of the blinding, potential unblinding, and open-label designs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Research & Regulatory Affairs is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLINDNESS
KW - PLACEBOS (Medicine)
KW - VISION disorders
KW - CLINICAL trials
KW - MEDICAL research
KW - MEDICAL care
KW - Bias
KW - Comparative clinical trial
KW - Imprecision
KW - Statistical evidence
N1 - Accession Number: 16858374; Sue-Jane Wang 1; Email Address: wangs@cder.fda.gov Nevius, S. Edward 1; Affiliation: 1: Division of Biometrics II, Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA.; Source Info: 2004, Vol. 21 Issue 3/4, p213; Subject Term: BLINDNESS; Subject Term: PLACEBOS (Medicine); Subject Term: VISION disorders; Subject Term: CLINICAL trials; Subject Term: MEDICAL research; Subject Term: MEDICAL care; Author-Supplied Keyword: Bias; Author-Supplied Keyword: Comparative clinical trial; Author-Supplied Keyword: Imprecision; Author-Supplied Keyword: Statistical evidence; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 17p; Document Type: Article
L3 - 10.1081/CRP-200050001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16858374&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lushniak, Boris D.
T1 - Occupational contact dermatitis.
JO - Dermatologic Therapy
JF - Dermatologic Therapy
Y1 - 2004/09//
VL - 17
IS - 3
M3 - Article
SP - 272
EP - 277
PB - Wiley-Blackwell
SN - 13960296
AB - The dermatologist should be aware of the many facets of occupational skin diseases, which can be caused by physical, chemical, and biological insults. The most common manifestation of occupational skin diseases is contact dermatitis (both irritant and allergic). Three factors point out the importance of occupational skin diseases as diseases that have a public health impact: 1) occupational skin diseases are common; 2) they often have a poor prognosis; and 3) they result in a noteworthy economic impact for society and for an individual. They are also diseases amenable to public health interventions. Specific industries and exposures may put a worker at risk of occupational contact dermatitis. The accuracy of the diagnosis of occupational contact dermatitis is related to the skill level, experience, and knowledge of the medical professional who makes the diagnosis and confirms the relationship with a workplace exposure. Prevention of occupational contact dermatitis is important, and a variety of prevention strategies are available. [ABSTRACT FROM AUTHOR]
AB - Copyright of Dermatologic Therapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - EPIDEMIOLOGY
KW - SKIN diseases
KW - DERMATOLOGY
KW - PUBLIC health
KW - contact dermatitis
KW - dermatitis
KW - epidemiology
KW - occupational contact dermatitis
KW - skin diseases
N1 - Accession Number: 13266348; Lushniak, Boris D. 1; Email Address: BLushniak@cdc.gov; Affiliation: 1: US Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio; Source Info: Sep2004, Vol. 17 Issue 3, p272; Subject Term: CONTACT dermatitis; Subject Term: EPIDEMIOLOGY; Subject Term: SKIN diseases; Subject Term: DERMATOLOGY; Subject Term: PUBLIC health; Author-Supplied Keyword: contact dermatitis; Author-Supplied Keyword: dermatitis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: occupational contact dermatitis; Author-Supplied Keyword: skin diseases; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 3 Color Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1396-0296.2004.04032.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoebe, Christian J. P. A.
AU - De Melker, Hester
AU - Spanjaard, Lodewijk
AU - Dankert, Jacob
AU - Nagelkerke, Nico
T1 - Space-Time Cluster Analysis of Invasive Meningococcal Disease.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2004/09//
VL - 10
IS - 9
M3 - Article
SP - 1621
EP - 1626
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Clusters are recognized when meningococcal cases of the same phenotypic strain (markers: serogroup, serotype, and subtype) occur in spatial and temporal proximity. The incidence of such clusters was compared to the incidence that would be expected by chance by using space-time nearest-neighbor analysis of 4,887 confirmed invasive meningococcal cases identified in the 9-year surveillance period 1993-2001 in the Netherlands. Clustering beyond chance only occurred among the closest neighboring cases (comparable to secondary cases) and was small (3.1%, 95% confidence interval 2.1%-4.1%). [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Neisseria meningitidis
KW - Phenotype
KW - Cluster analysis (Statistics)
KW - Correlation (Statistics)
KW - Netherlands
N1 - Accession Number: 14388862; Hoebe, Christian J. P. A. 1; Email Address: hoebec@ggdozl.nl; De Melker, Hester 2; Spanjaard, Lodewijk 3; Dankert, Jacob 3; Nagelkerke, Nico 2; Affiliations: 1: Eastern South Limburg Municipal Public Health Service, Heerlen, Netherlands; 2: National Institute of Public Health and the Environment, Bilthoven, Netherlands; 3: Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam, Netherlands; Issue Info: Sep2004, Vol. 10 Issue 9, p1621; Subject Term: Neisseria meningitidis; Subject Term: Phenotype; Subject Term: Cluster analysis (Statistics); Subject Term: Correlation (Statistics); Subject: Netherlands; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nurkiewicz, Timothy A.
AU - Porter, Dale W.
AU - Barger, Mark
AU - Castranova, Vincent
AU - Boegehold, Matthew A.
T1 - Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/09//
VL - 112
IS - 13
M3 - Article
SP - 1299
EP - 1306
PB - Superintendent of Documents
SN - 00916765
AB - Acute exposure to airborne pollutants such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified. The purpose of this study was to determine if pulmonary exposure to a PM surrogate. such as residual oil fly ash (ROFA)1 affects endotheliume&pendent dilation in the systemic microcirculation. Rats were intratracheally instilled with ROFA at 0.1, 0.25. 1 or 2 mg/rat 24 hr before experimental measurements. Rats intratracheally instilled with saline or titanium dioxide (0.25 mg/rat) served as vehicle or particle control groups. respectively. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar dilator responses to the Ca2+ ionophore A23187, administered by ejection via pressurized micropipette into the arteriolar lumen. We used analysis of bronchoalveolar lavage (BAL) samples to monitor identified pulmonary inflammation and damage. To determine if ROFA exposure affected arteriolar nitric oxide sensitivity, sodium nitroprusside was iontophoretically applied to arterioles of nu exposed to ROFA. In saline-treated rats, A23187 dilated arterioles up to 72 ± 7% of maximum. In ROFA- and TiO2-exposed rats, A23187-induced dilation was significantly attenuated. BAL fluid analysis revealed measurable pulmonary inflammation and damage after exposure to 1 and 2 mg ROFA (but not TiO2 or < 1 mg ROFA), as evidenced by significantly higher polymorphonudear kulcocyte cell counts, enhanced BAL albumin levels, and increased lactate dehydrogenase activity in SAL fluid. The sensitivity of arteriolar smooth muscle to NO was similar in saline-treated and ROFA-exposed rats, suggesting that pulmonary exposure to ROFA affected endothelial rather than smooth muscle function. A significant increase in venular kulcocyte adhesion and rolling was observed in ROFA-exposed a suggesting local inflammation at the systemic microvascular level. These results indicate that pulmonary PM exposure impairs systemic endothelium-dependent arteriolar dilation Moreover, because rats exposed to < 1 mg ROFA or TiO2 did not exhibit SAL signs of pulmonary damage or inflammation, it appears that PM exposure can impair systemic microvascular function independently of detectable pulmonary inflammation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - DISEASES
KW - Endothelium
KW - Cardiovascular diseases
KW - Pulmonary artery
KW - Diagnosis
KW - arteriole
KW - endothelium
KW - nitric oxide
KW - particulate matter
KW - residual oil fly ash
KW - ROFA
KW - spinotrapezius muscle
KW - systemic microcirculation
KW - titanium dioxide
N1 - Accession Number: 14665005; Nurkiewicz, Timothy A. 1,2; Porter, Dale W. 1,3; Barger, Mark 3; Castranova, Vincent 1,3; Boegehold, Matthew A. 1,2; Affiliations: 1: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, USA; 2: Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA; 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Sep2004, Vol. 112 Issue 13, p1299; Thesaurus Term: Air pollution; Thesaurus Term: DISEASES; Subject Term: Endothelium; Subject Term: Cardiovascular diseases; Subject Term: Pulmonary artery; Subject Term: Diagnosis; Author-Supplied Keyword: arteriole; Author-Supplied Keyword: endothelium; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: particulate matter; Author-Supplied Keyword: residual oil fly ash; Author-Supplied Keyword: ROFA; Author-Supplied Keyword: spinotrapezius muscle; Author-Supplied Keyword: systemic microcirculation; Author-Supplied Keyword: titanium dioxide; Number of Pages: 8p; Document Type: Article
L3 - 10.1289/ehp.7001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nam, K. T.
AU - Oh, S. -Y.
AU - Ahn, B.
AU - Kim, Y. B.
AU - Jang, D. D.
AU - Yang, K. -H.
AU - Hahm, K. -B.
AU - Kim, D. -Y.
T1 - Decreased Helicobacter pylon associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase.
JO - Gut
JF - Gut
Y1 - 2004/09//
VL - 53
IS - 9
M3 - Article
SP - 1250
EP - 1255
SN - 00175749
AB - Background and aims: Overproduction of nitric oxide via inducible nitric oxide synthase (iNOS) is suggested to be a significant pathogenic factor in Helicobacter Pylori induced gastritis. The purpose of this study was to examine the role of iNOS in H Pylori associated gastric carcinogenesis. Methods: Two types of mice were used in this study: iNOS deficient mice (iNOS-/-) and wild-type liltermates. Gastric cancer was generated in mice using a combination treatment comprising N-methyl-N-nitrosourea administration and H Pylori infection. Fifty weeks alter treatment, tumours in gastric tissues from both types of mice were examined using histopathology, immunohistochemistry, and immunoblotting for iNOS and 3-nitrolyrosine. Results: The overall incidence of gastric cancer at week 50 was significantly lower in iNOS-/- compared with iNOS wild-type mice (pp<0.0001 ) and that the protection effectiveness provided by AutoROPS will be superior to the protection provided by manual ROPS (p<0.01 ). Of great prevention importance was the increase in interest in purchasing a tractor with an AutoROPS compared to purchasing a tractor with manual ROPS (p<0.0001 ). This result indicates that this new technology may successfully achieve wide use on the farm. Farmer opinions indicate the need for further design work to improve seating restraint and the method for lowering the structure. Based on the results of this study, NIOSH will be able to make recommendations to companies interested in developing and manufacturing an AutoROPS for the farm workplace. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural implements
KW - Agricultural equipment
KW - Ergonomics
KW - Design
KW - Evaluation
KW - Passive protection
KW - ROPS
KW - Usability
N1 - Accession Number: 13624279; Etherton, John; Email Address: jrel@cdc.gov; McKenzie Jr., E.A. 1; Lutz, Tim 1; Cantis, Doug 1; Kau, Tsui-Ying 1; Affiliations: 1: Centres for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown WV 26505-2888, USA; Issue Info: Sep2004, Vol. 34 Issue 3, p155; Thesaurus Term: Agricultural implements; Thesaurus Term: Agricultural equipment; Subject Term: Ergonomics; Author-Supplied Keyword: Design; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Passive protection; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: Usability; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ergon.2004.03.007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yabroff, K Robin
AU - Lawrence, William F.
AU - Clauser, Steven
AU - Davis, William W.
AU - Brown, Martin L.
T1 - Burden of Illness in Cancer Survivors: Findings From a Population-Based National Sample.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2004/09//9/1/2004
VL - 96
IS - 17
M3 - Article
SP - 1322
EP - 1330
SN - 00278874
AB - Background: Population trends in aging and improved cancer survival are likely to result in increased cancer prevalence in the United States, but few estimates of the burden of illness among cancer survivors are currently available. The purpose of this study was to estimate the burden of illness in cancer survivors in a national, population-based sample. Methods: A total of 1823 cancer survivors and 5469 age-, sex-, and educational attainment-matched control subjects were identified from the 2000 National Health Interview Survey. Multiple measures of burden, including utility, a summary measure of health, and days lost from work, were compared using two-sided tests of statistical significance for the two groups overall and for subgroups stratified by tumor site and time since diagnosis. Results: Compared with matched control subjects, cancer survivors had poorer outcomes across all burden measures (P<.01). Cancer survivors had lower utility values (0.74 versus 0.80; P<.001) and higher levels of lost productivity and were more likely to report their health as fair or poor (31.0% versus 17.9%; P<.001) than matched control subjects. Cancer survivors reported statistically significantly higher burden than did control subjects across tumor sites and across time since diagnosis (i.e., within the past year, 2-5 years, 6-10 years, and ≥11 years for the majority of measures. Conclusions: Cancer survivors have poorer health outcomes than do similar individuals without cancer across multiple burden measures. These decrements are consistent across tumor sites and are found in patients many years following reported diagnosis. Improved measurement of long-term burden of illness will be important for future prospective research. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER patients
KW - DISEASES
KW - TUMORS
KW - DEMOGRAPHIC surveys
KW - CANCER research
KW - UNITED States
N1 - Accession Number: 14524671; Yabroff, K Robin 1; Email Address: yabroffr@mail.nih.gov Lawrence, William F. 2 Clauser, Steven 1 Davis, William W. 1 Brown, Martin L. 1; Affiliation: 1: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 2: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rock- yule, MD; Source Info: 9/1/2004, Vol. 96 Issue 17, p1322; Subject Term: CANCER patients; Subject Term: DISEASES; Subject Term: TUMORS; Subject Term: DEMOGRAPHIC surveys; Subject Term: CANCER research; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 30p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1093/jnci/djh255
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Jager, Lowm S.
AU - Perfetti, Gracia A.
AU - Diachenk, Gregory W.
T1 - Liquid Chromatographic Determination of St. John's Wort Components in Functional Foods.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1042
EP - 1048
SN - 10603271
AB - Discusses a method for determining St. John's wort marker compounds, hypericin, pseudohypericin, hyperforin and adhyperforim in functional foods, using liquid chromatography (LC). Solid-phase extraction; Detection of analytes; Electrospray ionization LC mass spectrometry.
KW - FUNCTIONAL foods
KW - HYPERICUM
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - ANALYTICAL chemistry
KW - DIETARY supplements
KW - MASS spectrometry
N1 - Accession Number: 14542670; De Jager, Lowm S. 1; Email Address: Ldejager@cfsan.fda.gov Perfetti, Gracia A. 1 Diachenk, Gregory W. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1042; Subject Term: FUNCTIONAL foods; Subject Term: HYPERICUM; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ANALYTICAL chemistry; Subject Term: DIETARY supplements; Subject Term: MASS spectrometry; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 7p; Illustrations: 1 Diagram, 6 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Idowu, Olutosin R.
AU - Kijak, Philip J.
AU - Meinertz, Jeffery R.
AU - Schmidt, Larry J.
T1 - Development and Validation of a Gas Chromatography/Mass Spectrometry Procedure for Confirmation of Para-Toluenesulfonamide in Edible Fish Fillet Tissue.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1098
EP - 1108
SN - 10603271
AB - Studies the development and validation of a gas chromatography/mass spectrometry procedure for confirmation of para-toluenesulfonamide (p-TSA) in edible fish fillet tissue. Chemical and reagent solutions; Extraction of p-TSA from fortified or incurred fillet tissue; Back-extraction of p-TSA.
KW - GAS chromatography
KW - CHROMATOGRAPHIC analysis
KW - MASS spectrometry
KW - FISH fillets
KW - ANALYTICAL chemistry
KW - CHLORAMINE-T
N1 - Accession Number: 14542677; Idowu, Olutosin R. 1; Email Address: oidowu@cvm.fda.gov Kijak, Philip J. 1 Meinertz, Jeffery R. 2 Schmidt, Larry J. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Rd, Laurel, MD 20708 2: U.S. Geological Survey, Biological Resources Division, Upper Midwest Environmental Sciences Center, 2630 Fanta Reed Rd, La Crosse, WI 54603; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1098; Subject Term: GAS chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MASS spectrometry; Subject Term: FISH fillets; Subject Term: ANALYTICAL chemistry; Subject Term: CHLORAMINE-T; Number of Pages: 11p; Illustrations: 3 Diagrams, 5 Charts, 15 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobson, Andrew P.
AU - Thunberg, Richard L.
AU - Johnson, Mildred L.
AU - Hammack, Thomas S.
AU - Andrews, Wallace H.
T1 - Alternative Anaerobic Enrichments to the Bacteriological Analytical Manual Culture Method for Isolation of Shigella sonnei from Selected Types of Fresh Produce.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1115
EP - 1122
SN - 10603271
AB - Studies the alternative anaerobic enrichments to the "Bacteriological Analytical Manual" culture method for isolation of Shigella sonnei from selected types of fresh produce. Preparation of inoculum for unstressed cell studies; Recovery of chill and freeze-stressed Shigella sonnei with alternative reducing agents; Isolation of Shigella sonnei from produce with GasPak and Oxyrase for borth anaerobic enrichment methods.
KW - SHIGELLA sonnei
KW - ANAEROBIC bacteria
KW - BACTERIOLOGY
KW - BACTERIAL cultures
KW - ANALYTICAL chemistry
KW - FOOD contamination
N1 - Accession Number: 14542679; Jacobson, Andrew P. 1; Email Address: andrew.jacobson@fda.hhs.gov Thunberg, Richard L. 1 Johnson, Mildred L. 1 Hammack, Thomas S. 1 Andrews, Wallace H. 1; Affiliation: 1: U.S. Food and Drug Administration, Division of Microbiological Studies, HFS-516, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1115; Subject Term: SHIGELLA sonnei; Subject Term: ANAEROBIC bacteria; Subject Term: BACTERIOLOGY; Subject Term: BACTERIAL cultures; Subject Term: ANALYTICAL chemistry; Subject Term: FOOD contamination; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chase Jr., G. William
AU - Lin Ye
AU - Stoakes, Vicky C.
AU - Eitenmiller, Ronald R.
AU - Long, Austin R.
T1 - An Interlaboratory-Verified Method for the Determination of Vitamins A and E in Milk- and Soy-Based Infant Formula by Liquid Chromatography with Matrix Solid-Phase Dispersion Extraction.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1173
EP - 1178
SN - 10603271
AB - Discusses an interlaboratory-verified method for the determination of vitamins A and E in milk and soy-based infant formula by liquid chromatography with matrix solid-phase dispersion extraction. Evaporation and filtration process; Recoveries of retinyl palmitate; Extraction and cleanup.
KW - INFANT formulas
KW - SOYMILK
KW - VITAMIN A
KW - VITAMIN E
KW - CHROMATOGRAPHIC analysis
KW - ANALYTICAL chemistry
KW - LIQUID chromatography
N1 - Accession Number: 14542686; Chase Jr., G. William 1; Email Address: William.chase@fda.gov Lin Ye 2 Stoakes, Vicky C. 1 Eitenmiller, Ronald R. 2 Long, Austin R. 1; Affiliation: 1: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30602 2: University of Georgia, Department of Food Science and Technology, Athens, GA 30309; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1173; Subject Term: INFANT formulas; Subject Term: SOYMILK; Subject Term: VITAMIN A; Subject Term: VITAMIN E; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ANALYTICAL chemistry; Subject Term: LIQUID chromatography; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 6p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mercer, Gregory E.
AU - Hurlbut, Jeffrey A.
T1 - A Multiresidue Pesticide Monitoring Procedure Using Gas Chromatography/Mass Spectrometry and Selected Ion Monitoring for the Determination of Pesticides Containing Nitrogen, Sulfur, and/or Oxygen...
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1224
EP - 1236
SN - 10603271
AB - Studies a multiresidue pesticide monitoring procedure using gas chromatography/mass spectrometry (GC/MS) and selected ion monitoring for the determination of pesticides containing nitrogen, sulfur and/or oxygen in fruits and vegetables. Confirmation of pesticide residues; Quantitation of a pesticide by GC/MS; Limit of quantitation; Results of regulatory sample analysis.
KW - PESTICIDES
KW - GAS chromatography
KW - MASS spectrometry
KW - FOOD additives
KW - IONIZATION (Atomic physics)
KW - ANALYTICAL chemistry
N1 - Accession Number: 14542693; Mercer, Gregory E. 1; Email Address: gmercer@ora.fda.gov Hurlbut, Jeffrey A. 2; Affiliation: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, WA 98021 2: Western Washington University, Chemistry Department, Bellingham, WA 98225-9150; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1224; Subject Term: PESTICIDES; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: FOOD additives; Subject Term: IONIZATION (Atomic physics); Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 13p; Illustrations: 7 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Podhorniak, Lynda V.
AU - Schenck, Frank J.
AU - Krynitsky, Alexander
AU - Griffith Jr., Francis
T1 - Multiresidue Method for N-Methyl Carbamates and Metabolite Pesticide Residues at the Parts-per-Billion Level in Selected Representative Commodities of Fruit and Vegetable Crop Groups.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/09//Sep/Oct2004
VL - 87
IS - 5
M3 - Article
SP - 1237
EP - 1251
SN - 10603271
AB - Studies the multiresidue method for N-methyl carbamates and metabolite pesticide residues at the parts-per-billion level in selected representative commodities of fruit and vegetable crop groups. Acetone extraction; Solid-phase extraction cleanup; Determination of residues by liquid chromatography.
KW - CROP residues
KW - CARBAMATES
KW - PESTICIDES
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - ANALYTICAL chemistry
N1 - Accession Number: 14542694; Podhorniak, Lynda V. 1; Email Address: Podhorniak.Lynda@epa.gov Schenck, Frank J. 2 Krynitsky, Alexander 3 Griffith Jr., Francis 4; Affiliation: 1: U.S. Environmental Protection Agency, Office of Pesticide Programs, Biological and Economic Analysis Division, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd, Mail Code 7503C, Rm C209, Fort George G Meade, MD 20755-5350 2: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St NE, Atlanta, GA 30309 3: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740-38350 4: U.S. Environmental Protection Agency, Office of Pesticide Programs, Biological and Economic Analysis Division, Analytical Chemistry Branch, 701 Mapes Rd, Fort George G. Meade, MD 20755-5350; Source Info: Sep/Oct2004, Vol. 87 Issue 5, p1237; Subject Term: CROP residues; Subject Term: CARBAMATES; Subject Term: PESTICIDES; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 15p; Illustrations: 1 Diagram, 9 Charts, 13 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liming Yuan
AU - Lazzara, Charles P.
T1 - The Effects of Ventilation and Preburn Time on Water Mist Extinguishing of Diesel Fuel Pool Fires.
JO - Journal of Fire Sciences
JF - Journal of Fire Sciences
Y1 - 2004/09//
VL - 22
IS - 5
M3 - Article
SP - 379
EP - 494
SN - 07349041
AB - The goal of the National Institute for Occupational Safety and Health (NIOSH) Pittsburgh Research Laboratory Fire Fighting and Prevention Program is to reduce the number of fires and fire-related injuries in the mining industry. As part of this effort, water mist is being evaluated for the suppression of underground mine fires, such as fires in diesel fuel storage areas. In this study a series of large-scale fire tests was conducted to investigate the effects of ventilation and preburn time on water mist extinguishing of three diesel fuel pool fires with heat release rates of 230 kW, 1, and 3 MW. The experiments were conducted in a simulated underground coal mine diesel fuel storage area under three ventilation conditions: no ventilation, natural ventilation, and forced ventilation and with two preburn times for the no ventilation condition: 30 s and 1 mm. Without ventilation the 230 kW fire was the most difficult to extinguish; with natural ventilation the 1 MW fire took the longest time to extinguish; and with forced ventilation the 3 MW fire was the most challenging one. With the 30-s preburn time, the extinguishing time was nearly the same for the 230 kW fire as with the 1-mm preburn time, while it increased for both 1 and 3 MW fires, with the 1 MW fire being the most difficult to extinguish. The extinguishing mechanisms including fuel surface cooling, flame cooling, and oxygen depletion and displacement are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Fire Sciences is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel fuels
KW - Ventilation
KW - Industrial safety
KW - Fire extinction
KW - Mine fires -- Prevention & control
KW - Cooling
KW - fire suppression
KW - pool fires
KW - water mist
N1 - Accession Number: 14419808; Liming Yuan 1; Email Address: lcy6@cdc.gov; Lazzara, Charles P. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mills Road, Pittsburgh, PA 15236, USA; Issue Info: Sep2004, Vol. 22 Issue 5, p379; Thesaurus Term: Diesel fuels; Thesaurus Term: Ventilation; Thesaurus Term: Industrial safety; Subject Term: Fire extinction; Subject Term: Mine fires -- Prevention & control; Subject Term: Cooling; Author-Supplied Keyword: fire suppression; Author-Supplied Keyword: pool fires; Author-Supplied Keyword: water mist; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 922160 Fire Protection; Number of Pages: 26p; Illustrations: 1 Diagram, 4 Charts, 5 Graphs; Document Type: Article
L3 - 10.1177/0734904104042438
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brito, G.
AU - Novotná, K.
AU - Peña-Méndez, E. M.
AU - Díaz, C.
AU - García, F. J.
T1 - Correlation of Heavy Metal Concentrations with Various Factors in Canned Liver Paste Products Using Multivariate Statistical Strategies.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/09//
VL - 67
IS - 9
M3 - Article
SP - 1927
EP - 1932
SN - 0362028X
AB - The content of Cu, Fe, Mn, Zn, Co, Crk, Ni, and Pb were determined in 496 samples of heat-treated canned liver pastes by atomic absorption spectrometry. Canned samples were classified according to the presence or absence of coated varnish on the inner side of the can. For each sample, two subsamples were taken: one from the area in contact with the side of the can, the other from the center of the container. Univariate (correlation, box and whisker) and multivariate (quality control charts, principal component analysis, and factor analysis) statistical techniques were applied to detect the presence of outliers and for exploratory data analysis. No significant differences (P < 0.05) were found between the subsamples considered, presence or absence of coated varnish, the sampling areas, or countries of origin. The multivariate analysis allows for the interpretation of grouping tendencies in samples. Crk, Ni, and Pb were associated with presence or absence of oxide in the can, and the essential metals (Fe, Cu, Zn, and Co) were associated with the kind of can. The samples tended to differentiate according to the type of container. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Heavy metals
KW - Canned foods
KW - Atomic absorption spectroscopy
KW - Multivariate analysis
N1 - Accession Number: 14543358; Brito, G. 1,2; Novotná, K. 1; Peña-Méndez, E. M. 1; Email Address: empena@ull.es; Díaz, C. 1; García, F. J. 1; Affiliations: 1: Department of Analytical Chemistry, Nutrition and Food Chemistry, Faculty of Chemistry, University of La Laguna, Campus de Anchieta, 38071-La Laguna, Tenerife, Spain; 2: Department of Health, Canary Islands Public Health Service, Canary Government, 38004-S/C de Tenerjfe, Tenerife, Spain; Issue Info: Sep2004, Vol. 67 Issue 9, p1927; Thesaurus Term: Food contamination; Thesaurus Term: Heavy metals; Subject Term: Canned foods; Subject Term: Atomic absorption spectroscopy; Subject Term: Multivariate analysis; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311422 Specialty Canning; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buchanan, Robert L.
AU - Dennis, Sherri
AU - Miliotis, Marianne
T1 - Initiating and Managing Risk Assessments within a Risk Analysis Framework: FDA/CFSAN'S Practical Approach.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/09//
VL - 67
IS - 9
M3 - Article
SP - 2058
EP - 2062
SN - 0362028X
AB - Management of risk analysis involves the integration and coordination of activities associated with risk assessment, risk management, and risk communication. Risk analysis is used to guide regulatory decision making, including trade decisions at national and international levels. The U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition (CFSAN) formed a working group to evaluate and improve the quality and consistency of major risk assessments conducted by the Center. Drawing on risk analysis experiences, CFSAN developed a practical framework for initiating and managing risk assessments, including addressing issues related to (i) commissioning a risk assessment, (ii) interactions between risk managers and risk assessors, and (iii) peer review. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Risk assessment
KW - Food -- Safety measures
KW - United States
KW - Center for Food Safety & Applied Nutrition (U.S.)
N1 - Accession Number: 14543378; Buchanan, Robert L. 1; Email Address: robert@buchanan@cfsan.fda.gov; Dennis, Sherri 1; Miliotis, Marianne 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-06, 5100 Paint Branch Parkway 2B64, College Park, Maryland 20740-3835, USA; Issue Info: Sep2004, Vol. 67 Issue 9, p2058; Thesaurus Term: Health risk assessment; Thesaurus Term: Risk assessment; Thesaurus Term: Food -- Safety measures; Subject: United States ; Company/Entity: Center for Food Safety & Applied Nutrition (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Claycamp, H. Gregg
AU - Hooberman, Barry H.
T1 - Antimicrobial Resistance Risk Assessment in Food Safety.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/09//
VL - 67
IS - 9
M3 - Article
SP - 2063
EP - 2071
SN - 0362028X
AB - Microbiological risk assessments generally focus on estimating adverse human health risks from exposures to human pathogenic microbes. The assessment of potential human health risks posed by pathogens that have acquired resistance to antimicrobial drugs is a new application of risk assessment that is closely related to microbiological risk assessment. Antimicrobial resistance risk assessment is a risk analytical process that focuses on resistance determinants as hazardous agents that might lead to drug-resistant microbial infections in humans exposed to bacteria carrying the determinants. Antimicrobialresistant infections could occur directly from actively invading or opportunistic pathogens or indirectly from the transfer of resistance genes to other bacteria. Here, we discuss risk assessment models that might be employed to estimate risks from drug-resistant bacteria in the animal food pathway and the types of models and data that may be used for microbiological risk assessments or antimicrobial resistance risk assessments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Food -- Safety measures
KW - Food -- Microbiology
KW - Microbiology
KW - Risk assessment
N1 - Accession Number: 14543379; Claycamp, H. Gregg 1; Email Address: hclaycam@cvm.fda.gov; Hooberman, Barry H. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7519 Standish Place, HFV 102, Rockville, Maryland 20855, USA; Issue Info: Sep2004, Vol. 67 Issue 9, p2063; Thesaurus Term: Health risk assessment; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Microbiology; Thesaurus Term: Risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Illustrations: 4 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buchanan, Robert L.
T1 - 1st International Conference on Microbiological Risk Assessment: Foodborne HazardsA—What We Heard.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/09//
VL - 67
IS - 9
M3 - Article
SP - 2072
EP - 2074
SN - 0362028X
AB - Outlines discussions on the application of microbiological risk assessment (MRA) to various food safety issues during the First International Conference on Microbiological Risk Assessment: Foodborne Hazards. Challenges and opportunities; Interaction between risk assessors and managers; Resources for risk assessors; Standard MRA practices.
KW - Risk assessment
KW - Food -- Safety measures
KW - Food handling
KW - Food -- Microbiology
KW - Sanitary microbiology
N1 - Accession Number: 14543380; Buchanan, Robert L. 1; Email Address: robert.buchanan@cfsan.fda.gov; Affiliations: 1: U.S. Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway 2B64, College Park, Maryland 20740-3835, USA; Issue Info: Sep2004, Vol. 67 Issue 9, p2072; Thesaurus Term: Risk assessment; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food handling; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Sanitary microbiology; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lin, Feng-Ying C.
AU - Weisman, Leonard E.
AU - Azimi, Parvin H.
AU - Philips III, Joseph B.
AU - Clark, Penny
AU - Regan, Joan
AU - Rhoads, George G.
AU - Frasch, Carl E.
AU - Gray, Barry M.
AU - Troendle, James
AU - Brenner, Ruth A.
AU - Moyer, Patricia
AU - Clemens, John D.
T1 - Level of Maternal IgG Anti--Group B Streptococcus Type III Antibody Correlated with Protection of Neonates against Early-Onset Disease Caused by This Pathogen.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/09//9/1/2004
VL - 190
IS - 5
M3 - Article
SP - 928
EP - 934
SN - 00221899
AB - The present study estimates the level of maternal immunoglobulin (Ig) G anti-group B streptococcus (GBS) type III required to protect neonates against early-onset disease (EOD) caused by this pathogen. Levels of maternal serum IgG anti-GBS type III, measured by enzyme-linked immunosorbent assay, in 26 case patients (neonates with EOD caused by GBS type III) and 143 matched control subjects (neonates colonized by GBS type III who did not develop EOD) of ≥34 weeks gestation were compared. The probability of EOD decreased with increasing levels of maternal IgG anti-GBS type III (P = .01). Neonates whose mothers had ≥10 µg/mL IgG anti-GBS type III had a 91% lower risk for EOD, compared with those whose mothers had levels of <2 µg/mL. A vaccine that induces IgG anti-GBS type III levels of ≥10 µg/mL in mothers can be predicted to offer a significant degree of protection against EOD caused by this pathogen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOLOGY
KW - Immune response
KW - Pathogenic microorganisms
KW - Newborn infants
KW - Maternally acquired immunity
KW - Streptococcus
KW - Immunoglobulins
N1 - Accession Number: 14052758; Lin, Feng-Ying C. 1; Email Address: link@exchange.nih.gov; Weisman, Leonard E. 2; Azimi, Parvin H. 3; Philips III, Joseph B. 4; Clark, Penny; Regan, Joan 5; Rhoads, George G. 6; Frasch, Carl E. 7; Gray, Barry M. 8; Troendle, James 1; Brenner, Ruth A. 1; Moyer, Patricia 1; Clemens, John D. 9; Affiliations: 1: National Institute of Child Health and Human Development, National Institutes of Health; 2: Baylor College of Medicine, Houston, Texas; 3: Children's Hospital Medical Center of Northern California, Oakland; 4: University of Alabama at Birmingham, Birmingham; 5: Columbia University Health Sciences, New York, New York; 6: University of Dentistry and Medicine of New Jersey, Piscataway; 7: Center for Biologics Research and Review, Food and Drug Administration, Department of Health and Human Services, Bethesda, Maryland; 8: Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria; 9: International Vaccine Institute, Seoul, South Korea; Issue Info: 9/1/2004, Vol. 190 Issue 5, p928; Thesaurus Term: IMMUNOLOGY; Thesaurus Term: Immune response; Thesaurus Term: Pathogenic microorganisms; Subject Term: Newborn infants; Subject Term: Maternally acquired immunity; Subject Term: Streptococcus; Subject Term: Immunoglobulins; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DeVincenzo, John P.
AU - Hall, Caroline B.
AU - Kimberlin, David W.
AU - Sánchez, Pablo J.
AU - Rodriguez, William J.
AU - Jantausch, Barbara A.
AU - Corey, Lawrence
AU - Kahn, Jeffrey S.
AU - Englund, Janet A.
AU - Suzich, JoAnn A.
AU - Palmer-Hill, Frances J.
AU - Branco, Luis
AU - Johnson, Syd
AU - Patel, Nita K.
AU - Piazza, Franco M.
T1 - Surveillance of Clinical Isolates of Respiratory Syncytial Virus for Palivizumab (Synagis)--Resistant Mutants.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/09//9/1/2004
VL - 190
IS - 5
M3 - Article
SP - 975
EP - 978
SN - 00221899
AB - Premature infants and those with chronic lung disease or congenital heart disease are at high risk of severe respiratory syncytial virus (RSV) disease. Palivizumab (Synagis), a humanized anti-RSV monoclonal antibody, has been used extensively since 1998 to prevent severe RSV disease in high-risk infants. To monitor for possible palivizumab-resistant mutants, an immunofluorescence binding assay that predicts palivizumab neutralization of RSV was developed. RSV isolates were collected at 8 US sites from 458 infants hospitalized for RSV disease (1998-2002). Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Respiratory syncytial virus
KW - Lung diseases
KW - Monoclonal antibodies
KW - Congenital heart disease
KW - Nosocomial infections in children
N1 - Accession Number: 14052776; DeVincenzo, John P. 1; Email Address: jdevincenzo@utmem.edu; Hall, Caroline B. 2; Kimberlin, David W. 3; Sánchez, Pablo J. 4; Rodriguez, William J. 5; Jantausch, Barbara A. 6; Corey, Lawrence 7; Kahn, Jeffrey S. 8; Englund, Janet A. 7; Suzich, JoAnn A. 9; Palmer-Hill, Frances J.; Branco, Luis 9; Johnson, Syd 9; Patel, Nita K. 9; Piazza, Franco M. 9; Affiliations: 1: University of Tennessee, LeBonheur Children's Medical Center and Children's Foundation Research Center, Memphis; 2: University of Rochester, Rochester, New York; 3: University of Alabama, Birmingham; 4: University of Texas Southwestern Medical Center at Dallas, Dallas; 5: Food and Drug Administration, Office of Counterterrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Washington, DC; 6: Children's National Medical Center, Washington, DC; 7: University of Washington, Seattle; 8: Yale University, New Haven, Connecticut; 9: MedImmune, Gaithersburg, Maryland; Issue Info: 9/1/2004, Vol. 190 Issue 5, p975; Thesaurus Term: Immune response; Subject Term: Respiratory syncytial virus; Subject Term: Lung diseases; Subject Term: Monoclonal antibodies; Subject Term: Congenital heart disease; Subject Term: Nosocomial infections in children; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PAN, CHRISTOPHER S.
AU - MILLER, KIMBERLY M.
AU - CHIOU, SHARON
AU - WU, JOHN Z.
T1 - EVALUATION OF A COMPUTER-SIMULATION MODEL FOR HUMAN AMBULATION ON STILTS.
JO - Journal of Mechanics in Medicine & Biology
JF - Journal of Mechanics in Medicine & Biology
Y1 - 2004/09//
VL - 4
IS - 3
M3 - Article
SP - 283
EP - 303
PB - World Scientific Publishing Company
SN - 02195194
AB - Stilts are elevated tools that are frequently used by construction workers to raise workers 18 to 40 inches above the ground without the burden of erecting scaffolding or a ladder. Some previous studies indicated that construction workers perceive an increased risk of injury when working on stilts. However, no in-depth biomechanical analyses have been conducted to examine the fall risks associated with the use of stilts. The objective of this study is to evaluate a computer-simulation stilts model. Three construction workers were recruited for walking tasks on 24-inch stilts. The model was evaluated using whole body center of mass and ground reaction forces. A PEAK™ motion system and two Kistler™ force platforms were used to collect data on both kinetic and kinematic measures. Inverse- and direct-dynamics simulations were performed using a model developed using commercial software — ADAMS and LifeMOD. For three coordinates (X, Y, Z) of the center of mass, the results of univariate analyses indicated very small variability for the mean difference between the model predictions and the experimental measurements. The results of correlation analyses indicated similar trends for the three coordinates. Plotting the resultant and vertical ground reaction force for both right and left feet showed small discrepancies, but the overall shape was identical. The percentage differences between the model and the actual measurement for three coordinates of the center of mass, as well as resultant and vertical ground reaction force, were within 20%. This newly-developed stilt walking model may be used to assist in improving the design of stilts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Mechanics in Medicine & Biology is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER simulation
KW - ELECTROMECHANICAL analogies
KW - SIMULATION methods & models
KW - BIOMECHANICS
KW - STILTS
KW - DYNAMICS
KW - KINEMATICS
KW - biomechanics
KW - Computer simulation
KW - direct-dynamics
KW - gait
KW - gait.
KW - inverse-dynamics
KW - model evaluation
KW - multi-body dynamics
KW - stilts
N1 - Accession Number: 14259372; PAN, CHRISTOPHER S. 1; Email Address: cpan@cdc.gov MILLER, KIMBERLY M. 1 CHIOU, SHARON 1 WU, JOHN Z. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Sep2004, Vol. 4 Issue 3, p283; Subject Term: COMPUTER simulation; Subject Term: ELECTROMECHANICAL analogies; Subject Term: SIMULATION methods & models; Subject Term: BIOMECHANICS; Subject Term: STILTS; Subject Term: DYNAMICS; Subject Term: KINEMATICS; Author-Supplied Keyword: biomechanics; Author-Supplied Keyword: Computer simulation; Author-Supplied Keyword: direct-dynamics; Author-Supplied Keyword: gait; Author-Supplied Keyword: gait.; Author-Supplied Keyword: inverse-dynamics; Author-Supplied Keyword: model evaluation; Author-Supplied Keyword: multi-body dynamics; Author-Supplied Keyword: stilts; Number of Pages: 21p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Osterkamp, Linda Kautz
AU - Longstaff, Laura
T1 - Development of a Dietary Teaching Tool for American Indians and Alaskan Natives in Southern Arizona.
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
Y1 - 2004/09//Sep/Oct2004
VL - 36
IS - 5
M3 - Article
SP - 272
EP - 274
PB - Elsevier Science
SN - 14994046
AB - The article focuses on the development of a dietary teaching tool for American Indians and Alaskan Natives in Southern Arizona. Nutrition education is needed throughout the United States and the world as people face the growing epidemics of poor nutrition, obesity, and health issues resulting from them. To facilitate nutrition education of the public, the U.S. Department of Agriculture (USDA) developed the food guide pyramid as a teaching tool in 1992. To be effective, teaching materials must address the needs and desires of a variety of people; therefore, modification of a basic educational tool is sometimes necessary to increase its relevance to the targeted audience. A major health issue for American Indians and Alaskan Natives in the United States is poor nutrition. American Indians and Alaskan Natives have been removed from or limited within native tribal lands for the past 2 centuries, thereby causing significant changes in the availability at traditional foods. Now displacement and near-poverty living conditions are among the factors that preclude traditional methods of provision, which can lead to dependence on government-supplied commodity foods. Geographic constraints and local food environments impact food quality.
KW - DIETARIES
KW - NATIVE Americans
KW - NUTRITION -- Study & teaching
KW - BODY weight
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 15495521; Osterkamp, Linda Kautz; Email Address: oster2@mindspring.com Longstaff, Laura 1; Affiliation: 1: US Public Health Service, Bethesda, MD.; Source Info: Sep/Oct2004, Vol. 36 Issue 5, p272; Subject Term: DIETARIES; Subject Term: NATIVE Americans; Subject Term: NUTRITION -- Study & teaching; Subject Term: BODY weight; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kerr, Lesley N.
AU - Chaput, Maria P.
AU - Cash, Lisa D.
AU - O'Malley, Louis G.
AU - Sarhrani, Elmiloudi M.
AU - Teixeira, Joseph C.
AU - Bolvin, William S.
AU - Mailhot, Seth A.
T1 - Assessment of the Durability of Medical Examination Gloves.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/09//
VL - 1
IS - 9
M3 - Article
SP - 607
EP - 612
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study determined the durability of various types of medical examination gloves using a laboratory test developed by the researchers. Results of this testing are compared with a simulated clinical method, also developed by the researchers, found to produce failures at rates similar to actual clinical use. Ten types of exam gloves were tested. One set of gloves was tested using a glove durability method. A second set was worn and conditioned using a simulated clinical method for comparison. The third set consisted of a control set of gloves that were not stressed. Samples consisted of 100 gloves combined from 2 or 4 manufacturers. All gloves were water-leak tested as the last step. The glove durability method created failures at similar rates to the simulated clinical method. The majority of the defects were located in the finger regions of the gloves. Durability of powdered and powder-free vinyl gloves was inferior to that of other glove types tested, with failure rates ranging from 24% to 42%, compared with 3% to 17% for the other glove types tested. Glove durability was also affected by the powdered state of the gloves and the user having long fingernails. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Surgical gloves
KW - Diagnosis
KW - Surgical instruments & apparatus
KW - Powders
KW - Fingernails
KW - Clinical medicine
KW - glove durability
KW - leakage
KW - medical examination gloves
KW - simulated clinical use
N1 - Accession Number: 14622923; Kerr, Lesley N. 1; Email Address: lesley.kerr@fda.gov; Chaput, Maria P. 1; Cash, Lisa D. 1; O'Malley, Louis G. 1; Sarhrani, Elmiloudi M. 1; Teixeira, Joseph C. 1; Bolvin, William S. 1; Mailhot, Seth A.; Affiliations: 1: U.S. Food and Drug Administration, Winchester, Massachusetts; Issue Info: Sep2004, Vol. 1 Issue 9, p607; Subject Term: Surgical gloves; Subject Term: Diagnosis; Subject Term: Surgical instruments & apparatus; Subject Term: Powders; Subject Term: Fingernails; Subject Term: Clinical medicine; Author-Supplied Keyword: glove durability; Author-Supplied Keyword: leakage; Author-Supplied Keyword: medical examination gloves; Author-Supplied Keyword: simulated clinical use; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/15459620490491803
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14622923&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hazelwood, Kyle J.
AU - Drake, Pamela L.
AU - Ashley, Kevin
AU - Marcy, Dale
T1 - Field Method for the Determination of Insoluble or Total Hexavalent Chromium in Workplace Air.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/09//
VL - 1
IS - 9
M3 - Article
SP - 613
EP - 619
PB - Taylor & Francis Ltd
SN - 15459624
AB - National Institute for Occupational Safety and Health method 7703 is a portable field procedure for the analysis of workplace air filter samples for hexavalent chromium (CrVI) content immediately after the samples are collected. The field method prescribes CrVI extraction from air filter samples with an ammonium sulfate/ammonium hydroxide extraction buffer using ultrasonic extraction (UE). Strong anion-exchange solid-phase extraction (SAE-SPE) is then used to separate CrVI from trivalent chromium and other interferences. Portable spectrophotometric measurement of CrVI is then conducted using the 1,5-diphenylcarbazide (DPC) method. However, it has been found that the ammonium extraction buffer does not adequately bring insoluble CrVI compounds into solution during the UE process. Thus, it was deemed necessary to modify the field method so that it would provide acceptable recoveries for insoluble CrVI compounds. To this end, a more alkaline extraction solution—sodium carbonate/sodium bicarbonate buffer—was investigated. The modified procedure using the highly alkaline extraction solution was demonstrated to be compatible with SAE-SPE cartridges when determining insoluble CrVI in air filter samples. It was found that the carbonate/bicarbonate buffer was equally effective for complete dissolution of both insoluble and soluble forms of CrVI. Furthermore, the modified procedure met desired performance criteria established for air sampling and analytical methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hexavalent chromium
KW - Air filters
KW - Ammonium sulfate
KW - Dust control
KW - Air -- Purification
KW - Work environment
KW - field method
KW - hexavalent chromium
KW - insoluble chromates
KW - on-site analysis
KW - sample preparation
KW - workplace air
N1 - Accession Number: 14622924; Hazelwood, Kyle J. 1; Drake, Pamela L. 1; Email Address: PDrake@cdc.gov; Ashley, Kevin 2; Marcy, Dale 3; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane, Washington; 2: U.S. Department of Health and Human Services, Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: North Idaho College, Coeur D'Alene, Idaho; Issue Info: Sep2004, Vol. 1 Issue 9, p613; Thesaurus Term: Hexavalent chromium; Thesaurus Term: Air filters; Thesaurus Term: Ammonium sulfate; Thesaurus Term: Dust control; Thesaurus Term: Air -- Purification; Subject Term: Work environment; Author-Supplied Keyword: field method; Author-Supplied Keyword: hexavalent chromium; Author-Supplied Keyword: insoluble chromates; Author-Supplied Keyword: on-site analysis; Author-Supplied Keyword: sample preparation; Author-Supplied Keyword: workplace air; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15459620490493810
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14622924&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mazzuckelli, Larry
AU - Methner, M.M.
T1 - Identification of Potential Sources of Arsenic Exposure During Scrapyard Work at a Former Uranium Enrichment Facility.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/09//
VL - 1
IS - 9
M3 - Article
SP - D96
EP - D100
PB - Taylor & Francis Ltd
SN - 15459624
AB - Discusses a case study on the identification of potential sources of arsenic exposure during scrapyard work at a former uranium enrichment facility. Request for a Health Hazard Evaluation from union workers and management of a former uranium enrichment facility in Ohio; Operation of the facility by a nongovernment contractor and subcontractors; Presence of arsenic in the inner surfaces of the workers' respirators and urine.
KW - Arsenic
KW - Chemical plants
KW - Uranium
KW - Employees
KW - Respirators (Medical equipment)
KW - Urine
KW - Ohio
KW - United States
N1 - Accession Number: 14622922; Mazzuckelli, Larry 1; Methner, M.M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Sep2004, Vol. 1 Issue 9, pD96; Thesaurus Term: Arsenic; Thesaurus Term: Chemical plants; Thesaurus Term: Uranium; Subject Term: Employees; Subject Term: Respirators (Medical equipment); Subject Term: Urine; Subject: Ohio; Subject: United States; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 236210 Industrial Building Construction; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1080/15459620490484621
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14622922&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106683414
T1 - Assessment of the durability of medical examination gloves.
AU - Kerr LN
AU - Chaput MP
AU - Cash LD
AU - O'Malley LG
AU - Sarhrani EM
AU - Teixeira JC
AU - Boivin WS
AU - Mailhot SA
Y1 - 2004/09//
N1 - Accession Number: 106683414. Language: English. Entry Date: 20041008. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D101-3. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Gloves -- Evaluation
KW - Surgical Equipment and Supplies
KW - Chi Square Test
KW - Coefficient Alpha
KW - Education, Continuing (Credit)
KW - Human
SP - 607
EP - 612
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study determined the durability of various types of medical examination gloves using a laboratory test developed by the researchers. Results of this testing are compared with a simulated clinical method, also developed by the researchers, found to produce failures at rates similar to actual clinical use. Ten types of exam gloves were tested. One set of gloves was tested using a glove durability method. A second set was worn and conditioned using a simulated clinical method for comparison. The third set consisted of a control set of gloves that were not stressed. Samples consisted of 100 gloves combined from 2 or 4 manufacturers. All gloves were water-leak tested as the last step. The glove durability method created failures at similar rates to the simulated clinical method. The majority of the defects were located in the finger regions of the gloves. Durability of powdered and powder-free vinyl gloves was inferior to that of other glove types tested, with failure rates ranging from 24% to 42%, compared with 3% to 17% for the other glove types tested. Glove durability was also affected by the powdered state of the gloves and the user having long fingernails.
SN - 1545-9624
AD - U.S. Food and Drug Administration, Winchester Engineering and Analytical Center, 109 Holton St., Winchester, MA 01890; lesley.kerr@fda.gov
U2 - PMID: 15559332.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106683413
T1 - Field method for the determination of insoluble or total hexavalent chromium in workplace air.
AU - Hazelwood KJ
AU - Drake PL
AU - Ashley K
AU - Marcy D
Y1 - 2004/09//
N1 - Accession Number: 106683413. Language: English. Entry Date: 20041008. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D101-3. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Chromium Compounds -- Adverse Effects
KW - Environmental Monitoring -- Methods
KW - Occupational Exposure
KW - Education, Continuing (Credit)
KW - National Institute for Occupational Safety and Health
KW - Human
SP - 613
EP - 619
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - National Institute for Occupational Safety and Health method 7703 is a portable field procedure for the analysis of workplace air filter samples for hexavalent chromium (Cr[VI]) content immediately after the samples are collected. The field method prescribes Cr[VI] extraction from air filter samples with an ammonium sulfate/ammonium hydroxide extraction buffer using ultrasonic extraction (UE). Strong anion-exchange solid-phase extraction (SAE-SPE) is then used to separate Cr[VI] from trivalent chromium and other interferences. Portable spectrophotometric measurement of Cr[VI] is then conducted using the 1,5-diphenylcarbazide (DPC) method. However, it has been found that the ammonium extraction buffer does not adequately bring insoluble Cr[VI] compounds into solution during the UE process. Thus, it was deemed necessary to modify the field method so that it would provide acceptable recoveries for insoluble Cr[VI] compounds. To this end, a more alkaline extraction solution--sodium carbonate/sodium bicarbonate buffer--was investigated. The modified procedure using the highly alkaline extraction solution was demonstrated to be compatible with SAE-SPE cartridges when determining insoluble Cr[VI] in air filter samples. It was found that the carbonate/bicarbonate buffer was equally effective for complete dissolution of both insoluble and soluble forms of Cr[VI]. Furthermore, the modified procedure met desired performance criteria established for air sampling and analytical methods.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers of Disease Control and Prevention, National Institute for occupational Safety and Health, Spokane, WA
U2 - PMID: 15559333.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106683408
T1 - Case studies. Identification of potential sources of arsenic exposure during scrapyard work at a former uranium enrichment facility.
AU - Methner MM
A2 - Mazzuckelli L
Y1 - 2004/09//
N1 - Accession Number: 106683408. Language: English. Entry Date: 20041008. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Arsenic -- Poisoning
KW - Environmental Monitoring -- Methods
KW - National Institute for Occupational Safety and Health
KW - Ohio
SP - D96
EP - 100
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 15559327.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106683408&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thomas, Eric J.
AU - Sherwood, Gwen D.
AU - Muihollem, Jennipher L
AU - Sexton, J. Bryan
AU - Helmreich, Robert L.
T1 - Working Together in the Neonatal Intensive Care Unit: Provider Perspectives.
JO - Journal of Perinatology
JF - Journal of Perinatology
Y1 - 2004/09//
VL - 24
IS - 9
M3 - Article
SP - 552
EP - 559
SN - 07438346
AB - OBJECTIVES:: To elicit healthcare provider perceptions of working together in a neonatal intensive care unit (NICU). STUDY DESIGN:: We conducted focus groups to elicit descriptions of how providers work together. The groups included one each of transport nurses, staff nurses, residents, fellows, attending physicians and two multiple provider groups. To identify themes and their descriptive elements we performed qualitative data analysis. RESULTS:: There were three to seven participants per group for a total sample of 36. Provider responses to questions about working together centered around three major themes: (1) Provider Characteristics; (2) Workplace Factors and; (3) Group Influences. Provider Characteristics were defined by personal attributes, reputation, and expertise. Workplace Factors included staffing, work organization, and work environment. Group Influences were described by communication and relationships. CONCLUSIONS:: Providers in this NICU described three broad organizational and interpersonal factors that influence how they work together, yet no consistent descriptions of teams or teamwork were found. The organizational factors, often far removed from bedside, should be considered when evaluating how providers work together.Journal of Perinatology (2004) 24, 552-559. doi:10.1038/sj.jp.7211136 Published online 13 May 2004 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Perinatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - NEONATAL intensive care
KW - WORK environment
KW - INTERPERSONAL relations
KW - PERINATOLOGY
N1 - Accession Number: 14261878; Thomas, Eric J. 1,2 Sherwood, Gwen D. 1,2 Muihollem, Jennipher L 1,2 Sexton, J. Bryan 2,3 Helmreich, Robert L. 2,3; Affiliation: 1: University of Texas Health Science Center at Houston Medical School, and School of Nursing. 2: The University of Texas Center of Excellence for Patient Safety Research and Practice (Agency for Healthcare Research and Quality grant # IPO1HS1154401, TX USA. 3: The University of Texas at Department of Psychology and Human Factors Research Project.; Source Info: Sep2004, Vol. 24 Issue 9, p552; Subject Term: MEDICAL care; Subject Term: NEONATAL intensive care; Subject Term: WORK environment; Subject Term: INTERPERSONAL relations; Subject Term: PERINATOLOGY; Number of Pages: 8p; Document Type: Article
L3 - 10.1038/sj.jp.7211136
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14261878&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106559765
T1 - Readiness and response to public health emergencies: help needed now from professional nursing associations.
AU - Phillips S
AU - Lavin R
Y1 - 2004/09//2004 Sep-Oct
N1 - Accession Number: 106559765. Language: English. Entry Date: 20050114. Revision Date: 20150711. Publication Type: Journal Article. Commentary: Rowe DS. Readiness and response to public health emergencies help needed now from professional nursing associations. (NEV RNFORMATION) May2008; 17 (2): 15-15; Rowe DS. Readiness and response to public health emergencies: help needed now from professional nursing associations. (NEV RNFORMATION) Aug2008; 17 (3): 20-20. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - Disaster Planning -- United States
KW - Disasters
KW - Emergencies
KW - Nursing Organizations
KW - Public Policy -- United States
KW - Disaster Planning -- Legislation and Jurisprudence
KW - Legislation
KW - Nursing Role
KW - United States
KW - United States Department of Health and Human Services
SP - 279
EP - 280
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 20
IS - 5
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 8755-7223
AD - Bioterrorism Preparedness Research Program, Agency for Healthcare Research and Quality (AHRQ) Rockville, MD
U2 - PMID: 15494959.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106559765&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Davis, Joseph A.
AU - Brown, Aliza T.
AU - Chen, Hongjiang
AU - Wang, Yunfang
AU - Poirier, Lionel A.
AU - Eidt, John F.
AU - Cruz, Carlos P.
AU - Moursi, Mohammed M.
T1 - Cigarette smoke increases intimal hyperplasia and homocysteine in a rat carotid endarterectomy
JO - Journal of Surgical Research
JF - Journal of Surgical Research
Y1 - 2004/09//
VL - 121
IS - 1
M3 - Article
SP - 69
EP - 75
SN - 00224804
AB - Homocysteine and smoking are independent risks for CVD; however their importance in post-CEA intimal hyperplasia is unclear. We performed a CEA in rats exposed to cigarette smoke with the hypothesis that smoking would increase intimal hyperplasia that may be associated with an elevated serum homocysteine. Folic acid (FA) and the homocysteine metabolic enzymes MTHFR and CBS were used to test for the significance of homocysteine elevation.Rats underwent an open CEA. N = 13 rats received smoke exposure 2 weeks prior, and 2 weeks post-CEA and N = 12 received no smoke. Each group was divided into either control or an FA-added diet resulting in four groups. Rats were sacrificed at 2 weeks post-CEA; liver, urine, blood, and carotid arteries samples were obtained.Smoked rats had increased urinary peak and trough cotinine levels versus non-smoke rats, which decreased with FA. Smoke exposure increased intimal hyperplasia versus non-smoke controls by nearly 120% (57.8 ± 6.2 versus 26.8 ± 5.4% luminal stenosis, P = 0.005). Smoke-exposed rats had an increased serum homocysteine versus non-smoke controls (8.3 ± 0.8 versus 5.7 ± 0.8 μm, P = 0.014). Smoked rats given FA had decreased serum homocysteine compared to the smoke group. Along with reductions in homocysteine, FA eliminated the increase in intimal hyperplasia seen with smoke exposure (33.5 ± 6.1 versus 57.8 ± 6.2% luminal stenosis, P = 0.03). CBS activity decreased in smoked rats by nearly 20% versus non-smoke rats. FA supplementation in smoked rats both (1) increased CBS activity and (2) decreased MTHFR compared to control non-smoke-exposure levels.Smoking increases plasma homocysteine and post-CEA intimal hyperplasia. This suggests homocysteine has an etiological role in the intimal hyperplasia increase observed with smoking, since both were negated with FA. [Copyright &y& Elsevier]
AB - Copyright of Journal of Surgical Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERPLASIA
KW - SULFUR amino acids
KW - CELLULAR pathology
KW - PTERIDINES
KW - CBS
KW - cigarette
KW - folic acid
KW - homocysteine
KW - intimal hyperplasia
KW - MTHFR
N1 - Accession Number: 14101366; Davis, Joseph A. 1 Brown, Aliza T. 1 Chen, Hongjiang 1 Wang, Yunfang 1 Poirier, Lionel A. 2 Eidt, John F. 1 Cruz, Carlos P. 1 Moursi, Mohammed M.; Email Address: moursimohammedm@exchange.uams.edu; Affiliation: 1: University of Arkansas for Medical Sciences, Central Arkansas Veterans HealthCare System Little Rock, Arkansas 2: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas; Source Info: Sep2004, Vol. 121 Issue 1, p69; Subject Term: HYPERPLASIA; Subject Term: SULFUR amino acids; Subject Term: CELLULAR pathology; Subject Term: PTERIDINES; Author-Supplied Keyword: CBS; Author-Supplied Keyword: cigarette; Author-Supplied Keyword: folic acid; Author-Supplied Keyword: homocysteine; Author-Supplied Keyword: intimal hyperplasia; Author-Supplied Keyword: MTHFR; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jss.2004.04.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14101366&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, S. Lori
AU - Woo, Eileen K.
T1 - Surgical stapler-associated fatalities and adverse events reported to the food and drug administration
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
Y1 - 2004/09//
VL - 199
IS - 3
M3 - Article
SP - 374
EP - 381
SN - 10727515
AB - Background: Use of stapling devices has become standard practice in many operations, and these devices have many applications, including ligation and division, resection, anastomosis, and fascial closure. The Food and Drug Administration (FDA) regulates surgical staplers as a medical device. Manufacturers and health-care providers report adverse events occurring during the use of surgical staplers to the FDA.Study design: Two FDA adverse event databases, the Manufacturer and User Facility Device Experience database and the Alternative Summary Reporting database were searched for adverse events related to the use of surgical staplers. An FDA recall database, Oracle System Center Automated Retrieval, was searched for surgical stapler recalls and the reason for these recalls.Results: We characterized adverse events from 112 death, 2,180 injury, and 22,804 malfunction reports from FDA adverse event databases. We described 22 recalls for these products that are listed in an FDA database. A majority of these recalls were related to manufacturing or design problems.Conclusions: The overall incidence of these events remains unknown; because these products are used so frequently, even uncommon adverse events may affect many patients. It is important for health-care providers to report adverse events to manufacturers so that they may work to improve the design of these devices and reduce use errors that contribute to the events. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Surgeons is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAPLERS (Surgery)
KW - SUTURING -- Instruments
KW - EXCISION (Surgery)
KW - OPERATIVE surgery
N1 - Accession Number: 14189055; Brown, S. Lori 1 Woo, Eileen K. 1; Affiliation: 1: Epidemiology Branch and the Product Evaluation Branch, Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA; Source Info: Sep2004, Vol. 199 Issue 3, p374; Subject Term: STAPLERS (Surgery); Subject Term: SUTURING -- Instruments; Subject Term: EXCISION (Surgery); Subject Term: OPERATIVE surgery; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jamcollsurg.2004.05.264
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Forsman, Zac H.
AU - Lednicky, John A.
AU - Fox, George E.
AU - Wilison, Richard C.
AU - White, Zoe S.
AU - Halvorson, Steven J.
AU - Wong, Connie
AU - Lewis Jr., Andrew M.
AU - Butel, Janet S.
T1 - Phylogenetic Analysis of Polyomavirus Simian Virus 40 from Monkeys and Humans Reveals Genetic Variation.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/09//
VL - 78
IS - 17
M3 - Article
SP - 9306
EP - 9316
SN - 0022538X
AB - A phylogenetic analysis of 14 complete simian virus 40 (SV40) genomes was conducted in order to determine strain relatedness and the extent of genetic variation. This analysis included infectious isolates recovered between 1960 and 1999 from primary cultures of monkey kidney cells, from contaminated poliovaccines and an adenovirus seed stock, from human malignancies, and from transformed human cells. Maximum-parsimony and distance methods revealed distinct SV40 clades. However, no clear patterns of association between genotype and viral source were apparent. One clade (clade A) is derived from strain 776, the reference strain of SV40. Clade B contains isolates from poliovaccines (strains 777 and Baylor), from monkeys (strains N128, Rh911, and K661), and from human tumors (strains SVCPC and SVMEN). Thus, adaptation is not essential for SV40 survival in humans. The C terminus of the T-antigen (T-ag-C) gene contains the highest proportion of variable sites in the SV40 genome. An analysis based on just the T-ag-C region was highly congruent with the whole-genome analysis; hence, sequencing of just this one region is useful in strain identification. Analysis of an additional 16 strains for which only the T-ag-C gene was sequenced indicated that further SV40 genetic diversity is likely, resulting in a provisional clade (clade C) that currently contains strains associated with human tumors and human strain PML-1. Four other polymorphic regions in the genome were also identified. If these regions were analyzed in conjunction with the T-ag-C region, most of the phylogenetic signal could be captured without complete genome sequencing. This report represents the first whole-genome approach to establishing phylogenetic relatedness among different strains of SV40. It will be important in the future to develop a more complete catalog of SV40 variation in its natural monkey host, to determine if SV40 strains from different clades vary in biological or pathogenic properties, and to identify which SV40 strains are transmissible among humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SIMIAN viruses
KW - PHYLOGENY
KW - GENETICS
KW - TUMORS
KW - MONKEYS
KW - VIROLOGY
N1 - Accession Number: 14445496; Forsman, Zac H. 1 Lednicky, John A. 2 Fox, George E. 3 Wilison, Richard C. 3 White, Zoe S. 4 Halvorson, Steven J. 4 Wong, Connie 4 Lewis Jr., Andrew M. 5 Butel, Janet S. 4; Email Address: jbutel@bcm.tmc.edu; Affiliation: 1: Department of Biology, University of Hawaii at Manoa, Honolulu, HI 96815 2: Department of Pathology, Loyola University Medical Center, Maywood, IL 60153 3: Department of Biology and Biochemistiy, University of Houston, Texas 4: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 5: DNA Virus Laboratory, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: Sep2004, Vol. 78 Issue 17, p9306; Subject Term: SIMIAN viruses; Subject Term: PHYLOGENY; Subject Term: GENETICS; Subject Term: TUMORS; Subject Term: MONKEYS; Subject Term: VIROLOGY; Number of Pages: 11p; Illustrations: 4 Diagrams, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.17.9306-9316.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antani, Sameer
AU - Lee, D. J.
AU - Rodney Long, L.
AU - Thoma, George R.
T1 - Evaluation of shape similarity measurement methods for spine X-ray images.
JO - Journal of Visual Communication & Image Representation
JF - Journal of Visual Communication & Image Representation
Y1 - 2004/09//
VL - 15
IS - 3
M3 - Article
SP - 285
EP - 302
SN - 10473203
AB - Efficient content-based image retrieval (CBIR) of biomedical images is a challenging problem. Feature representation algorithms used in indexing medical images on the pathology of interest have to address conflicting goals of reducing feature dimensionality while retaining important and often subtle biomedical features. At the Lister Hill National Center for Biomedical Communications, an intramural R&D division of the U.S. National Library of Medicine, we are developing CBIR prototype for digitized images of a collection of 17,000 cervical and lumbar spine X-rays taken as a part of the second National Health and Nutrition Examination Survey (NHANES II). The vertebra shape effectively describes various pathologies identified by medical experts as being consistently and reliably found in the image collection. A suitable shape algorithm must represent shapes in low dimension, be invariant to rotation, translation, and scale transforms, and retain relevant pathology. Additionally, supported similarity algorithms must be useful in retrieving images that are relevant to the queries posed by the intended target community, viz. medical researchers, physicians, etc. This paper describes an evaluation of two popular shape similarity methods from the literature on a set of 250 vertebra boundary shapes. The polygon approximation method achieved a performance score of 55.94% and bettered the Fourier descriptor algorithm which had a performance score of 46.96%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Visual Communication & Image Representation is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Multimedia systems
KW - Diagnostic imaging
KW - Imaging systems in medicine
KW - Radiography
KW - Radiology
KW - Image retrieval
KW - Imaging systems
KW - Content-based image retrieval
KW - Medical image database
KW - Performance
KW - Shape representation
N1 - Accession Number: 14937314; Antani, Sameer 1; Email Address: antani@nlm.hih.gov; Lee, D. J. 2; Rodney Long, L. 1; Thoma, George R. 1; Affiliations: 1: Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20894, USA; 2: Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA; Issue Info: Sep2004, Vol. 15 Issue 3, p285; Thesaurus Term: Multimedia systems; Subject Term: Diagnostic imaging; Subject Term: Imaging systems in medicine; Subject Term: Radiography; Subject Term: Radiology; Subject Term: Image retrieval; Subject Term: Imaging systems; Author-Supplied Keyword: Content-based image retrieval; Author-Supplied Keyword: Medical image database; Author-Supplied Keyword: Performance; Author-Supplied Keyword: Shape representation; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.jvcir.2004.04.005
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
ID - 106561265
T1 - The National Survey of Children's Health: a new data resource.
AU - van Dyck P
AU - Kogan MD
AU - Heppel D
AU - Blumberg SJ
AU - Cynamon ML
AU - Newacheck PW
Y1 - 2004/09//
N1 - Accession Number: 106561265. Language: English. Entry Date: 20050114. Revision Date: 20150820. Publication Type: Journal Article; questionnaire/scale; tables/charts. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. NLM UID: 9715672.
KW - Child Health -- Trends -- United States
KW - Health Services Needs and Demand -- In Infancy and Childhood -- United States
KW - Psychological Well-Being -- In Infancy and Childhood -- United States
KW - Resource Databases, Health -- United States
KW - Child Development
KW - Data Collection, Computer Assisted
KW - Family Characteristics
KW - Government Agencies
KW - Health Promotion
KW - Health Resource Utilization
KW - Health Services Accessibility
KW - Health Status -- In Infancy and Childhood
KW - Healthy People 2010
KW - Instrument Construction
KW - Insurance, Health
KW - Random Sample
KW - Residence Characteristics
KW - Surveys
KW - Telephone
KW - United States
SP - 183
EP - 188
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 8
IS - 3
CY - ,
PB - Springer Science & Business Media B.V.
AB - Context: Federal and state maternal and child health programs are responsible for promoting and improving the health and well-being of children. To support achievement of this goal, the federal Maternal and Child Health Bureau (MCHB) in partnership with the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention has developed a new survey that will provide uniform national and state data on the health and well-being of children, as well as the characteristics of their families and neighborhoods. Purpose: The National Survey of Children's Health was designed to produce reliable and representative state- and national-level estimates for Healthy People 2010 national prevention objectives, for each state's Title V needs assessment, and for Title V program planning and evaluation. In addition, it will provide a new data resource for researchers, advocacy groups, and other interested parties. It is anticipated that this survey will be repeated periodically, making trend analysis possible. Methods: This survey was conducted using the State and Local Area Integrated Telephone Survey (SLAITS) mechanism, which shares the random-digit-dial sampling frame of the National Immunization Survey (sponsored by the National Immunization Program and NCHS). Using the SLAITS platform, interviews on approximately 2000 children were conducted in each state and the District of Columbia. The parent or guardian most knowledgeable about the child completed a battery of questions on health and development, health insurance coverage, access to care, utilization of health care services, presence of a medical home, family functioning, parental health, and neighborhood characteristics. Data collection began in January 2003 and continued through April 2004. Summary reports and electronic data files will be available to the public by early 2005. Conclusion: This is the second state and national survey jointly completed by MCHB and NCHS. It is designed to complement the 2001 National Survey of Children with Special Health Care Needs by providing data on the health of the general child population.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD
U2 - PMID: 15499874.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Votano, Joseph R.
AU - Parham, Marc
AU - Hall, Lowell H.
AU - Kier, Lemont B.
AU - Oloff, Scott
AU - Tropsha, Alexander
AU - Qian Xie
AU - Weida Tong
T1 - Three new consensus QSAR models for the prediction of Ames genotoxicity.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2004/09//
VL - 19
IS - 5
M3 - Article
SP - 365
EP - 377
PB - Oxford University Press / USA
SN - 02678357
AB - Three QSAR methods, artificial neural net (ANN), k-nearest neighbors (kNN), and Decision Forest (DF), were applied to 3363 diverse compounds tested for their Ames genotoxicity. The ratio of mutagens to non-mutagens was 60/40 for this dataset. This group of compounds includes >300 therapeutic drugs. All models were developed using the same initial set of 148 topological indices: molecular connectivity χ indices and electrotopological state indices (atom-type, bond-type and group-type E-state), as well as binary indicators. While previous studies have found logP to be a determining factor in genotoxicity, it was not found to be important by any modeling method employed in this study. The three models yielded an average training/test concordance value of 88%, with a low percentage of false positives and false negatives. External validation testing on 400 compounds not used for QSAR model development gave an average concordance of 82%. This value increased to 92% upon removal of less reliable outcomes, as determined by a reliability criterion used within each model. The ANN model showed the best performance in predicting drug compounds, yielding 97% concordance (34/35 drugs) after the removal of less reliable predictions. The appreciable commonality found among the top 10 ranked descriptors from each model is of particular interest because of the diversity in the learning algorithms and descriptor selection techniques employed in this study. Forty percent of the most important descriptors in any one model are found in one or two other models. Fourteen of the most important descriptors relate directly to known toxicophores involved in potent genotoxic responses in Salmonella typhimurium. A comparison of the validation results with those of MULTICASE and DEREK indicated that the new models presented in this work perform substantially better than the former models in predicting genotoxicity of therapeutic drugs. Substantially higher specificity was achieved with these new models as compared with MULTICASE or DEREK with comparable sensitivities among all models. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QSAR (Biochemistry)
KW - Structure-activity relationships (Biochemistry)
KW - Genetic toxicology
KW - Enterobacteriaceae
KW - Salmonella typhimurium
N1 - Accession Number: 20122127; Votano, Joseph R. 1; Email Address: jvotano@chemsilico.com; Parham, Marc 1; Hall, Lowell H. 2; Kier, Lemont B. 3; Oloff, Scott 4; Tropsha, Alexander 4; Qian Xie 1; Weida Tong 5; Affiliations: 1: ChemSilico LLC, 48 Baldwin Street, Tewksbury, MA 01876, USA; 2: Department of Chemistry, Eastern Nazarene College, Quincy, MA 02170, USA; 3: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA; 4: Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA; 5: Center for Toxicoinformatics, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AK 72079, USA; Issue Info: Sep2004, Vol. 19 Issue 5, p365; Thesaurus Term: QSAR (Biochemistry); Thesaurus Term: Structure-activity relationships (Biochemistry); Thesaurus Term: Genetic toxicology; Thesaurus Term: Enterobacteriaceae; Subject Term: Salmonella typhimurium; Number of Pages: 13p; Document Type: Article
L3 - 10.1093/mutage/geh043
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Temmerman, Stephane
AU - Pethe, Kevin
AU - Parra, Marcela
AU - Alonso, Sylvie
AU - Rouanet, Carine
AU - Pickett, Thames
AU - Drowart, Annie
AU - Debrie, Anne-Sophie
AU - Delogu, Giovanni
AU - Menozzi, Franco D.
AU - Sergheraert, Christian
AU - Brennan, Michael J.
AU - Mascart, Françoise
AU - Locht, Camille
T1 - Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2004/09//
VL - 10
IS - 9
M3 - Article
SP - 935
EP - 941
PB - Nature Publishing Group
SN - 10788956
AB - Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified peptides. Here we show that methylation of the Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA) by the bacterium is essential for effective T cell immunity to this antigen in infected healthy humans and in mice. Methylated HBHA provides high levels of protection against M. tuberculosis challenge in mice, whereas nonmethylated HBHA does not. Protective immunity induced by methylated HBHA is comparable to that afforded by vaccination with bacille Calmette et Guérin, the only available anti-tuberculosis vaccine. Thus, post-translational modifications of proteins may be crucial for their ability to induce protective T cell-mediated immunity against infectious diseases such as tuberculosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - B cells
KW - ANTIGENIC determinants
KW - T cells
KW - IMMUNITY
KW - CELLULAR immunity
KW - MOLECULAR immunology
N1 - Accession Number: 14307359; Temmerman, Stephane 1 Pethe, Kevin 2,3 Parra, Marcela Alonso, Sylvie 2,3 Rouanet, Carine 2 Pickett, Thames 4 Drowart, Annie 5 Debrie, Anne-Sophie 2 Delogu, Giovanni 4,6 Menozzi, Franco D. 2 Sergheraert, Christian 7 Brennan, Michael J. 4 Mascart, Françoise 1 Locht, Camille 2; Email Address: camille.locht@pasteur-lille.fr; Affiliation: 1: Laboratory of Immunology, Erasme Hospital, Universitéde Bruxelles, Route de Lennik, 808, B-1070 Brussels, Belgium 2: Unité INSERM U629, IBL, Institut Pasteur de Lille, 1, Rue du Professor Calmette, F-59019 Lille Cedex, France 3: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA 5: Department of Internal Medicine, Brugmann Hospital, Place Van Gehuchten, 4, B-1020 Brussels, Belgium 6: Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy 7: CNRS-Université Lille 2 UMR8525, IBL, Institut Pasteur de Lille, 1, rue du Prof. Calmette, F-59019 Lille Cedex, France; Source Info: Sep2004, Vol. 10 Issue 9, p935; Subject Term: ANTIGENS; Subject Term: B cells; Subject Term: ANTIGENIC determinants; Subject Term: T cells; Subject Term: IMMUNITY; Subject Term: CELLULAR immunity; Subject Term: MOLECULAR immunology; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1038/nm1090
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lesko, Lawrence J.
AU - Woodcock, Janet
T1 - Opinion: Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective.
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2004/09//
VL - 3
IS - 9
M3 - Article
SP - 763
EP - 769
PB - Nature Publishing Group
SN - 14741776
AB - Pharmacogenomics and pharmacogenetics provide methodologies that can lead to DNA-based tests to improve drug selection, identify optimal dosing, maximize drug efficacy or minimize the risk of toxicity. Rapid advances in basic research have identified many opportunities for the development of 'personalized' treatments for individuals and/or subsets of patients defined by genetic and/or genomic tests. However, the integration of these tests into routine clinical practice remains a major multidisciplinary challenge, and even for well-established biomarkers there has been little progress. Here, we consider this challenge from a regulatory perspective, highlighting recent initiatives from the FDA that aim to facilitate the integration of pharmacogenetics and pharmacogenomics into drug development and clinical practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - DRUG development
KW - MEDICAL genetics
KW - BIOCHEMICAL genetics
KW - PHARMACOLOGY
N1 - Accession Number: 14307203; Lesko, Lawrence J. 1; Email Address: leskol@cder.fda.gov Woodcock, Janet 2; Affiliation: 1: Director of the Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA 2: Acting Deputy Commissioner of Operations, Food and Drug Administration, Maryland, USA; Source Info: Sep2004, Vol. 3 Issue 9, p763; Subject Term: PHARMACOGENOMICS; Subject Term: DRUG development; Subject Term: MEDICAL genetics; Subject Term: BIOCHEMICAL genetics; Subject Term: PHARMACOLOGY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Document Type: Article
L3 - 10.1038/nrd1499
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106650872
T1 - Device safety. Burning beds.
AU - Todd JF
Y1 - 2004/09//
N1 - Accession Number: 106650872. Language: English. Entry Date: 20050712. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Beds and Mattresses
KW - Equipment Safety
KW - Fires -- Prevention and Control
SP - 23
EP - 23
JO - Nursing
JF - Nursing
JA - NURSING
VL - 34
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 15345931.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Feng, Rentian
AU - Bowman, Linda L.
AU - Lu, Yongju
AU - Leonard, Stephen S.
AU - Shi, Xianglin
AU - Jiang, Bing-Hua
AU - Castranova, Vince
AU - Vallyathan, Val
AU - Ding, Min
T1 - Blackberry Extracts Inhibit Activating Protein 1 Activation and Cell Transformation by Perturbing the Mitogenic Signaling Pathway.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2004/09//
VL - 50
IS - 1
M3 - Article
SP - 80
EP - 89
PB - Taylor & Francis Ltd
SN - 01635581
AB - Abstract: Blackberries are natural rich sources of bioflavonoids and phenolic compounds that are commonly known as potential chemopreventive agents. Here, we investigated the effects of fresh blackberry extracts on proliferation of cancer cells and neoplastic transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as well as the underlying mechanisms of signal transduction pathways. Using electron spin resonance, we found that blackberry extract is an effective scavenger of free radicals, including hydroxyl and superoxide radicals. Blackberry extract inhibited the proliferation of a human lung cancer cell line, A549. Pretreatment of A549 cells with blackberry extract resulted in an inhibition of 8-hydroxy-2′-deoxyguanosine (8-OHdG) formation induced by ultraviolet B (UVB) irradiation. Blackberry extract decreased TPA-induced neoplastic transformation of JB6 P+ cells. Pretreatment of JB6 cells with blackberry extract resulted in the inhibition of both UVB- and TPA-induced AP-1 transactivation. Furthermore, blackberry extract also blocked UVB- or TPA-induced phosphorylation of ERKs and JNKs, but not p38 kinase. Overall, these results indicated that an extract from fresh blackberry may inhibit tumor promoter-induced carcinogenesis and associated cell signaling, and suggest that the chemopreventive effects of fresh blackberry may be through its antioxidant properties by blocking reactive oxygen species-mediated AP-1 and mitogen-activated protein kinase activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLACKBERRIES
KW - BIOFLAVONOIDS
KW - PHENOLS
KW - CHEMOPREVENTION
KW - PREVENTIVE medicine
KW - CELL proliferation
KW - CANCER cells
KW - FREE radicals (Chemistry)
N1 - Accession Number: 15441005; Feng, Rentian 1 Bowman, Linda L. 1 Lu, Yongju 1 Leonard, Stephen S. 1 Shi, Xianglin 1 Jiang, Bing-Hua 2 Castranova, Vince 1 Vallyathan, Val 1 Ding, Min 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505. 2: Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506.; Source Info: 2004, Vol. 50 Issue 1, p80; Subject Term: BLACKBERRIES; Subject Term: BIOFLAVONOIDS; Subject Term: PHENOLS; Subject Term: CHEMOPREVENTION; Subject Term: PREVENTIVE medicine; Subject Term: CELL proliferation; Subject Term: CANCER cells; Subject Term: FREE radicals (Chemistry); NAICS/Industry Codes: 111334 Berry (except Strawberry) Farming; Number of Pages: 10p; Document Type: Article
L3 - 10.1207/s15327914nc5001_11
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Szarfman, Ana
AU - Tonning, Joseph M.
AU - Doraiswamy, P. Murali
T1 - Pharmacovigilance in the 21st Century: New Systematic Tools for an Old Problem.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2004/09//
VL - 24
IS - 9
M3 - Editorial
SP - 1099
EP - 1104
SN - 02770008
AB - The large number of adverse-event reports generated by marketed drugs and devices argues for the application of validated computerized algorithms to supplement traditional methods of detecting adverse-event signals. Difficulties in accurately estimating patient exposure and background rates for a given event in a specific population hinder risk estimation in spontaneous adverse-event databases. The United States Food and Drug Administration (FDA) is evaluating a Bayesian data mining system called Multi-item Gamma Poisson Shrinker (MGPS) to enhance the FDA's ability to monitor the safety of drugs, biologics, and vaccines after they have been approved for use. The MGPS computes adjusted higher-than-expected reporting relationships between drugs and adverse events across 35 years of data relative to internal background rates. The MGPS can also adjust for random noise by using a model derived from the data, and corrects for temporal trends and confounding related to age, sex, and other variables by stratifying over 900 categories. Signals can then be compared with or used in conjunction with other sources (e.g. clinical trials, general practice databases) to further study the adverse-event risk. The example of pancreatitis risk with atypical antipsychotics, valproic acid, and vaiproate is used to discuss the strengths and limitations of MGPS versus traditional methods. Validated data mining techniques offer great promise to enhance pharmacovigilance practices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Side effects
KW - MEDICAL research
KW - PANCREATITIS
KW - ANTIPSYCHOTIC drugs
KW - DATA mining
KW - VACCINATION -- Complications
KW - VACCINES
KW - adverse events
KW - AERS
KW - antipsychotics.
KW - data mining
KW - MGPS
KW - pancreatitis
KW - vaiproic acid
N1 - Accession Number: 14436817; Szarfman, Ana 1 Tonning, Joseph M. 1 Doraiswamy, P. Murali 2,3; Email Address: dorai001@mc.duke.edu; Affiliation: 1: Office of Pharmacoepidemiology and Statistical Sciences, Immediate Office, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland. 2: Department of Psychiatry, Duke University Medical Center, Durham, North Carolina. 3: Department of Medicine, Duke University Medical Center, Durham, North Carolina.; Source Info: Sep2004, Vol. 24 Issue 9, p1099; Subject Term: DRUGS -- Side effects; Subject Term: MEDICAL research; Subject Term: PANCREATITIS; Subject Term: ANTIPSYCHOTIC drugs; Subject Term: DATA mining; Subject Term: VACCINATION -- Complications; Subject Term: VACCINES; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: AERS; Author-Supplied Keyword: antipsychotics.; Author-Supplied Keyword: data mining; Author-Supplied Keyword: MGPS; Author-Supplied Keyword: pancreatitis; Author-Supplied Keyword: vaiproic acid; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahn, Hyun-Joo
AU - Kim, Jae-Hyun
AU - Jo, Cheorun
AU - Lee, Ju-Woon
AU - Yook, Hong-Sun
AU - Kim, Hee-Yun
AU - Byun, Myung-Woo
T1 - Combined effects of gamma irradiation and a modified atmospheric packaging on the physicochemical characteristics of sausage
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/09//
VL - 71
IS - 1/2
M3 - Article
SP - 53
EP - 56
SN - 0969806X
AB - This study is to investigate the combined effects of irradiation and a modified atmospheric packaging (MAP) on the color, nitrosoheme pigments (NO-Mb), residual nitrite and N-nitrosodimethylamine (NDMA) in sausage during storage. Sausage with air, vacuum, CO2, N2, or CO2/N2 packaging was irradiated at 5 kGy. Irradiation reduced the red color of sausage, and a vacuum or MAP was effective in minimizing the loss of redness. The reduction of NO-Mb was observed by irradiation, while the MAP was more effective in maintaining the NO-Mb than the aerobic ones. Residual nitrite was reduced by irradiation, and the contents were lower under vacuum or MAP than aerobic ones. NDMA was significantly reduced by irradiation. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAMMA rays -- Physiological effect
KW - PACKAGING
KW - SAUSAGES
KW - IRRADIATION
KW - Color
KW - Irradiation
KW - Modified atmosphere packaging
KW - Nitrite
KW - Nitrosamine
KW - Sausage
N1 - Accession Number: 14034463; Ahn, Hyun-Joo 1 Kim, Jae-Hyun 1 Jo, Cheorun 1 Lee, Ju-Woon 1 Yook, Hong-Sun 2 Kim, Hee-Yun 3 Byun, Myung-Woo 1; Email Address: mwbyun@kaeri.re.kr; Affiliation: 1: Radiation Food Science & Biotechnology Team, Korea Atomic Energy Research Institute, 150, Deokjin-Dong, Yuseong, Daejeon 305-353, South Korea 2: Department of Food and Nutrition, Chungnam National University, Daejeon 305-764, South Korea 3: Division of Food Additives, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Sep2004, Vol. 71 Issue 1/2, p53; Subject Term: GAMMA rays -- Physiological effect; Subject Term: PACKAGING; Subject Term: SAUSAGES; Subject Term: IRRADIATION; Author-Supplied Keyword: Color; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: Modified atmosphere packaging; Author-Supplied Keyword: Nitrite; Author-Supplied Keyword: Nitrosamine; Author-Supplied Keyword: Sausage; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2004.04.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jo, Cheorun
AU - Kim, Dong Ho
AU - Kim, Hee Yun
AU - Lee, Won Dong
AU - Lee, Hyo Ku
AU - Byun, Myung Woo
T1 - Studies on the development of low-salted, fermented, and seasoned Changran Jeotkal using the intestines of Therage chalcogramma
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/09//
VL - 71
IS - 1/2
M3 - Article
SP - 123
EP - 126
SN - 0969806X
AB - Low salt (5% salt content) Changran Jeotkal was prepared. Microbiological, chemical, and sensory qualities were compared with a commercially available sample (8% salt content). Irradiation at 2.5 kGy or higher significantly reduced the microbial contamination. The contents of volatile basic nitrogen (VBN) and amino nitrogen (AN) were also higher in the non-irradiated and low salted Jeotkal compared to the commercial control. However, 2.5 kGy of irradiation reduced the content of VBN and AN in Joetkal, and improved the chemical storage stability. A sensory evaluation indicated that 2.5 kGy-irradiated Changran Jeotkal with 5% salt content was more acceptable than the commercial control (8% salt content). The results show that irradiation can be applied for the development of low salted, seasoned Changran Jeotkal. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALT
KW - MICROBIAL contamination
KW - IRRADIATION
KW - GASTROINTESTINAL system
KW - Changran Jeotkal
KW - Irradiation
KW - Low salt
N1 - Accession Number: 14034478; Jo, Cheorun 1 Kim, Dong Ho 1 Kim, Hee Yun 2 Lee, Won Dong 3 Lee, Hyo Ku 4 Byun, Myung Woo 1; Email Address: mwbyun@kaeri.re.kr; Affiliation: 1: Korea Atomic Energy Research Institute, Radiation Food Science and Biotechnology Team, 150, Deokjin-Dong, Yuseong, Daejeon 305-353, South Korea 2: Division of Food Additives, Korea Food and Drug Administration, Seoul 122-704, South Korea 3: R&D Department, Hanseong Co. Ltd., Busan 602-812, South Korea 4: Department of Food Technology, Kongju National University, Choongnam 340-802, South Korea; Source Info: Sep2004, Vol. 71 Issue 1/2, p123; Subject Term: SALT; Subject Term: MICROBIAL contamination; Subject Term: IRRADIATION; Subject Term: GASTROINTESTINAL system; Author-Supplied Keyword: Changran Jeotkal; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: Low salt; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2004.04.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, Hyung-Wook
AU - Delincée, Henry
AU - Han, Sang-Bae
AU - Hong, Jin-Hwan
AU - Kim, Hee-Yun
AU - Kim, Myung-Chul
AU - Byun, Myung-Woo
AU - Kwon, Joong-Ho
T1 - Trials to identify irradiated chestnut (Castanea bungena) with different analytical techniques
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/09//
VL - 71
IS - 1/2
M3 - Article
SP - 181
EP - 184
SN - 0969806X
AB - Photostimulated luminescence (PSL) measurement, DNA comet assay, electron spin resonance (ESR) spectroscopy and thermoluminescence (TL) measurement were applied to identify irradiated chestnut. Samples were irradiated with 60Co γ-rays at 0–0.5 kGy. The PSL photon counts for irradiated chestnuts were too low to be distinguished from those of the non-irradiated sample. There was no difference in DNA comets between non-irradiated and irradiated chestnuts. ESR spectroscopy did not show any radiation-induced specific signals but a symmetric singlet. However, using TL, the shape of the glow curve (Glow 1) made it possible to identify the irradiated chestnuts. In addition, the TL glow ratio (Glow 1/Glow 2) obtained by normalization was less than 0.01 for the non-irradiated sample and ≥0.10 for irradiated ones, respectively. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHESTNUT
KW - THERMOLUMINESCENCE
KW - SPECTRUM analysis
KW - RADIATION
KW - Identification
KW - Irradiated chestnut
KW - Thermoluminescence
N1 - Accession Number: 14034490; Chung, Hyung-Wook 1; Email Address: chunghw@kfda.go.kr Delincée, Henry 2 Han, Sang-Bae 1 Hong, Jin-Hwan 1 Kim, Hee-Yun 3 Kim, Myung-Chul 1 Byun, Myung-Woo 4 Kwon, Joong-Ho 5; Affiliation: 1: Division of Food Standard, Department of Food Evaluation, Korea Food and Drug Administration (KFDA), Seoul 122-704, South Korea 2: Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid-und-Neu-Str. 9, D-76131 Karlsruhe, Germany 3: Division of Food Additives, Department of Food Additives Evaluation, KFDA, Seoul 122-704, South Korea 4: Department of Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-353, South Korea 5: Department of Food Science and Technology, Kyungpook National University, Daegu 702-701, South Korea; Source Info: Sep2004, Vol. 71 Issue 1/2, p181; Subject Term: CHESTNUT; Subject Term: THERMOLUMINESCENCE; Subject Term: SPECTRUM analysis; Subject Term: RADIATION; Author-Supplied Keyword: Identification; Author-Supplied Keyword: Irradiated chestnut; Author-Supplied Keyword: Thermoluminescence; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2004.04.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - May, J.C.
AU - Rey, L.
AU - Lee, Chi-Jen
AU - Arciniega, Juan
T1 - Evaluation of components of X-ray irradiated 7-valent pneumococcal conjugate vaccine and pneumococcal vaccine polyvalent and X-ray and gamma-ray irradiated acellular pertussis component of DTaP vaccine products
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/09//
VL - 71
IS - 1/2
M3 - Article
SP - 415
EP - 418
SN - 0969806X
AB - Samples of pneumococcal vaccine polyvalent, 7-valent pneumococcal conjugate vaccine, and two different diphtheria and tetanus toxoids and acellular pertussis vaccines adsorbed were irradiated with X-rays and/or gamma-rays (Co-60). Mouse IgG and IgM antibody responses (ELISA) for types 9V, 14, 18C, and 19F pneumococcal polysaccharides and conjugates indicated that the polysaccharides were more tolerant of the radiation than the conjugates. The mouse antibody response for the detoxified pertussis toxin (PT) antigen, filamentous hemagglutinin antigen (FHA), pertactin (PRN), and fimbriae types 2 and 3 (FIM) antigens for the appropriate vaccine type indicated that the antibody response was not significantly changed in the 25 kGy X-ray irradiated vaccines frozen in liquid nitrogen compared to the control vaccine. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - X-rays
KW - GAMMA rays
KW - IMMUNOGLOBULIN M
KW - ENZYME-linked immunosorbent assay
KW - 7-Valent pneumococcal conjugate vaccine
KW - Co-60 gamma irradiation
KW - DTaP vaccine
KW - Irradiated vaccines
KW - Pneumococcal polysaccharide vaccine polyvalent
KW - X-ray
N1 - Accession Number: 14034540; May, J.C. 1; Email Address: may@cber.fda.gov Rey, L. 2; Email Address: louis.rey@bluewin.ch Lee, Chi-Jen 1 Arciniega, Juan 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-406,1401 Rockville Pike, Rockville, MD 20852, USA 2: Professeur des Universites, Conseiller Scientifique, Chemin de Verdonnet 2, Lausanne CH-1010, Switzerland; Source Info: Sep2004, Vol. 71 Issue 1/2, p415; Subject Term: X-rays; Subject Term: GAMMA rays; Subject Term: IMMUNOGLOBULIN M; Subject Term: ENZYME-linked immunosorbent assay; Author-Supplied Keyword: 7-Valent pneumococcal conjugate vaccine; Author-Supplied Keyword: Co-60 gamma irradiation; Author-Supplied Keyword: DTaP vaccine; Author-Supplied Keyword: Irradiated vaccines; Author-Supplied Keyword: Pneumococcal polysaccharide vaccine polyvalent; Author-Supplied Keyword: X-ray; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2004.03.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slikker, William
AU - Nan Mei
AU - Tao Chen
T1 - N-Ethyl-N-nitrosourea (ENU) Increased Brain Mutations in Prenatal and Neonatal Mice but Not in the Adults.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/09//
VL - 81
IS - 1
M3 - Article
SP - 112
EP - 120
PB - Oxford University Press / USA
SN - 10966080
AB - The incidence of childhood cancer is increasing. One of the most common cancers for children under 15 years of age, gliomas for example, has been reported to have increased in incidence over the last 20 years by approximately 40%. The rising trend of childhood cancer in brain may be associated with environmental exposure to genotoxins and susceptibility to mutation in early development. To investigate age-dependent mutagenic sensitivity of brain tissue to genotoxins, the Big Blue mouse model was utilized in this study. Groups of five male mice were treated with a single dose of 120 mg/kg ENU transplacentally at three days before birth (prenatal), eight days (neonate) or eighteen weeks (adult) after birth. The animals were sacrificed six weeks after the treatment. The mutant frequencies and types of mutations in the brain cII gene from ENU-treated and concurrent control mice were determined. A significant increase in mutant frequencies over control was found in the prenatal and neonatal groups whereas there was no significant difference between the adult group and its control. Molecular analysis of the mutants also indicated that the mutational spectra from the ENU-treated mice were age-dependent. The percentage of A:T→T:A transversion, the typical type of mutation induced by ENU, was inversely related to the treatment age, whereas G:C→A: T transition was the main type of mutation in the adult group, the same as the control. These results demonstrate a differential mutagenic effect of ENU on the mouse brain depending on the stages of development and suggest an enhanced susceptibility of brain cancer hazard for perinatal exposure to genotoxicants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Animal models in research
KW - Genetic toxicology
KW - Mutagenicity testing
KW - Mutagens
KW - Animal mutation
KW - Mice as laboratory animals
KW - Brain abnormalities
KW - Nitrosoureas
KW - Big Blue mouse
KW - carcinogenesis
KW - development
KW - ethylnitrosourea
KW - mutagenesis
N1 - Accession Number: 20606098; Slikker, William 1; Nan Mei 2; Tao Chen 2; Email Address: tchen@nctr.fda.gov; Affiliations: 1: College of Letters and Science, University of California, Los Angeles, California 90024; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, Arkansas 72079; Issue Info: Sep2004, Vol. 81 Issue 1, p112; Thesaurus Term: RESEARCH; Thesaurus Term: Animal models in research; Thesaurus Term: Genetic toxicology; Thesaurus Term: Mutagenicity testing; Thesaurus Term: Mutagens; Subject Term: Animal mutation; Subject Term: Mice as laboratory animals; Subject Term: Brain abnormalities; Subject Term: Nitrosoureas; Author-Supplied Keyword: Big Blue mouse; Author-Supplied Keyword: carcinogenesis; Author-Supplied Keyword: development; Author-Supplied Keyword: ethylnitrosourea; Author-Supplied Keyword: mutagenesis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/toxsci/kfh177
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harris, Angela J.
AU - Shaddock, Joseph C.
AU - Delongchamp, Robert
AU - Dragan, Yvonne
AU - Casciano, Daniel A.
T1 - Comparison of Basal Gene Expression in Cultured Primary Rat Hepatocytes and Freshly Isolated Rat Hepatocytes.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2004/09//Sep/Oct2004
VL - 14
IS - 5
M3 - Article
SP - 257
EP - 270
PB - Taylor & Francis Ltd
SN - 15376516
AB - Cultured primary hepatocytes are one of the most suitable in vitro models for hepatic toxicological studies. Unfortunately, there is a temporal loss of liver-specific function in culture that limits their utility for some applications. Plating hepatocytes on a substratum has been shown to stabilize the differentiated phenotype for short-term culture. In order to identify the substratum that best supports in vivo basal hepatocyte gene expression profiles in vitro, the gene expression profiles of primary rat hepatocytes plated on collagen I in hepatocyte maintenance medium (HMM) or hepatocyte culture medium (HCM), or on matrigel in HMM medium for 2 h, 16 h, or 72 h were compared to the expression profiles of freshly isolated rat hepatocytes using the Atlas rat stress array. After 16 h in culture, there were differences in gene expression between cultured primary hepatocytes and freshly isolated hepatocytes, but no apparent substratum effects. At 72 h, the expression of 9 genes was altered in hepatocytes plated on either substratum compared to expression in freshly isolated hepatocytes. However, there were an additional 13 genes with increased expression in hepatocytes plated on collagen I that were expressed at low or non-detectable levels in freshly isolated hepatocytes or primary hepatocytes plated on matrigel. In summary, after 72 h, primary hepatocytes plated on matrigel had basal gene expression patterns more similar to patterns in freshly isolated hepatocytes than did hepatocytes cultured on collagen. In addition, culture on matrigel suppressed the expression of atypical genes in culture. These preliminary studies suggest that culture on matrigel may be preferable for longer-term in vitro toxicological studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetics
KW - Gene expression
KW - Genetic regulation
KW - Liver cells
KW - Liver
KW - Cells
KW - Collagen I
KW - Filter Array
KW - Gene Expression
KW - Matrigel
KW - Primary Hepatocytes
N1 - Accession Number: 14350414; Harris, Angela J. 1; Shaddock, Joseph C. 2; Delongchamp, Robert 3; Dragan, Yvonne 1; Casciano, Daniel A. 4; Affiliations: 1: Center for Hepatotoxicity, National Center for Toxicological Research, Jefferson, Arkansas, USA; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA; 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas, USA; 4: Office of the Director, National Center for Toxicological Research, Jefferson, Arkansas, USA; Issue Info: Sep/Oct2004, Vol. 14 Issue 5, p257; Thesaurus Term: Genetics; Subject Term: Gene expression; Subject Term: Genetic regulation; Subject Term: Liver cells; Subject Term: Liver; Subject Term: Cells; Author-Supplied Keyword: Collagen I; Author-Supplied Keyword: Filter Array; Author-Supplied Keyword: Gene Expression; Author-Supplied Keyword: Matrigel; Author-Supplied Keyword: Primary Hepatocytes; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/15376520490434593
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - McClellan, Mark B.
T1 - Use of Outcomes Research in Assuring Patient Safety and Quality Care, Second Plenary Session, ISPOR 8th Annual International Meeting, Arlington, VA, USA.
JO - Value in Health
JF - Value in Health
Y1 - 2004/09//
VL - 7
IS - 5
M3 - Editorial
SP - 529
EP - 534
PB - Elsevier Science
SN - 15244733
AB - Discusses topics related to health and medical economics at the second plenary session of the ISPOR 8th Annual International Meeting in Arlington, Virginia. Use of outcomes research in assuring patient safety and quality care; Importance of medical economics; Main elements of medical innovation initiatives; Development of information technology tools.
KW - HEALTH
KW - OUTCOME assessment (Medical care)
KW - MEDICAL care -- Evaluation
KW - MEDICAL care -- Quality control
KW - MEDICAL innovations
KW - ARLINGTON (Va.)
KW - VIRGINIA
KW - UNITED States
N1 - Accession Number: 14359831; McClellan, Mark B. 1; Affiliation: 1: Commissioner, Food and Drug Administration, Rockville, MD, USA; Source Info: Sep2004, Vol. 7 Issue 5, p529; Subject Term: HEALTH; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL care -- Evaluation; Subject Term: MEDICAL care -- Quality control; Subject Term: MEDICAL innovations; Subject Term: ARLINGTON (Va.); Subject Term: VIRGINIA; Subject Term: UNITED States; Number of Pages: 6p; Document Type: Editorial
L3 - 10.1111/j.1524-4733.2004.75004.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Brien, Daniel J.
AU - Yereb, Daniel J.
AU - Cosgrove, Melinda K.
AU - Carlson, Elaine S.
AU - Schmitt, Stephen M.
AU - Wilkins, Melinda J.
T1 - From the Field: An occupational safety program for wildlife professionals involved with bovine tuberculosis surveillance.
JO - Wildlife Society Bulletin
JF - Wildlife Society Bulletin
Y1 - 2004///Fall2004
VL - 32
IS - 3
M3 - Article
SP - 992
EP - 999
SN - 00917648
AB - The discovery of bovine tuberculosis (caused by Mycobacterium bovis) in white-tailed deer (Odocoileus virginianus) and other free-ranging Michigan wildlife has made ongoing surveillance for the disease a reality for wildlife professionals. The wide susceptibility of mammals, including humans, to M. bovis led us to be concerned with the potential risks of acquiring tuberculosis that Michigan Department of Natural Resources staff face in their occupational activities. Consequently, we developed a bovine tuberculosis occupational safety program for our staff and volunteer cooperators taking part in disease surveillance. Close similarities between bovine and human tuberculosis allowed occupational safety principles used in human health care to be used as a guide. We produced an occupational safety training document to educate personnel about bovine tuberculosis in humans, evaluate the risk posed by job duties, and make recommendations on risk mitigation. Following implementation, the National Institute for Occupational Safety and Health conducted field evaluations of the occupational safety program that validated its protectiveness for workers. As wildlife disease surveillance becomes a greater responsibility for management agencies across the United States, we believe the lessons learned in development of the Michigan program can be widely adapted to other areas and potentially to other diseases, and can raise awareness of occupational exposure to zoonotic diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wildlife Society Bulletin is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS in cattle
KW - WHITE-tailed deer
KW - WILDLIFE managers
KW - MYCOBACTERIUM bovis
KW - ZOONOSES
KW - ANIMALS as carriers of disease
KW - bovine tuberculosis
KW - Mycobacterium bovis
KW - occupational safety
KW - wildlife disease surveillance
N1 - Accession Number: 15196115; O'Brien, Daniel J. 1; Email Address: obriend@michigan.gov Yereb, Daniel J. 2 Cosgrove, Melinda K. 1 Carlson, Elaine S. 3 Schmitt, Stephen M. 1 Wilkins, Melinda J. 4; Affiliation: 1: Rose Lake Wildlife Disease Laboratory, Michigan Department of Natural Resources, 8562 E. Stoll Road, East Lansing, MI 48823, USA 2: Field Studies Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 3: Mio Field Office, Wildlife Division, Michigan Department of Natural Resources, 191 S. Mt. Tom Road, Box 939, Mio, MI 48647, USA 4: Bureau of Epidemiology, Michigan Department of Community Health, 3423 N. Martin Luther King, Jr. Boulevard, Lansing, MI 48909, USA; Source Info: Fall2004, Vol. 32 Issue 3, p992; Subject Term: TUBERCULOSIS in cattle; Subject Term: WHITE-tailed deer; Subject Term: WILDLIFE managers; Subject Term: MYCOBACTERIUM bovis; Subject Term: ZOONOSES; Subject Term: ANIMALS as carriers of disease; Author-Supplied Keyword: bovine tuberculosis; Author-Supplied Keyword: Mycobacterium bovis; Author-Supplied Keyword: occupational safety; Author-Supplied Keyword: wildlife disease surveillance; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-18264-001
AN - 2004-18264-001
AU - Buck, Jeffrey A.
AU - Teich, Judith L.
AU - Graver, Linda
AU - Schroeder, Don
AU - Zheng, Dian
T1 - Utilization of Public Mental Health Services by Adults with Serious Mental Illness.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2004/09//
VL - 32
IS - 1
SP - 3
EP - 14
CY - Germany
PB - Springer
SN - 0894-587X
AD - Buck, Jeffrey A., SAMHSA/CMHS, 5600 Fishers Lane, 15-87, Rockville, MD, US, 20857
N1 - Accession Number: 2004-18264-001. Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; SAMHSA/CMHS, Rockville, MD, US. Release Date: 20040927. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Mental Disorders; Mental Health Services; Psychiatric Hospitalization; Public Health Services. Minor Descriptor: Medicaid; Psychiatric Hospitals. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Sep, 2004.
AB - Public mental health (MH) services were examined for non-elderly adults with serious mental illness (SMI) using a database combining information from Medicaid, MH, and substance abuse agencies in three states. These data show that between 23% and 39% of those with SMI received MH services only through Medicaid. Relative use of community versus state hospitals for delivery of psychiatric inpatient care varied across the three states. However, state hospitals accounted for a large proportion of total inpatient days, due to high mean annual days of care. In two states, Medicaid paid for fewer psychiatric inpatient days than expected. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health service utilization
KW - public mental health services
KW - mentally ill adults
KW - psychiatric inpatient care
KW - serious mental illness
KW - Medicaid
KW - 2004
KW - Health Care Utilization
KW - Mental Disorders
KW - Mental Health Services
KW - Psychiatric Hospitalization
KW - Public Health Services
KW - Medicaid
KW - Psychiatric Hospitals
KW - 2004
DO - 10.1023/B:APIH.0000039659.07516.1a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18264-001&site=ehost-live&scope=site
UR - jbuck@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18264-003
AN - 2004-18264-003
AU - Biebel, Kathleen
AU - Nicholson, Joanne
AU - Williams, Valerie
AU - Hinden, Beth R.
T1 - The Responsiveness of State Mental Health Authorities to Parents with Mental Illness.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2004/09//
VL - 32
IS - 1
SP - 31
EP - 48
CY - Germany
PB - Springer
SN - 0894-587X
AD - Biebel, Kathleen, Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2004-18264-003. PMID: 15527040 Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Biebel, Kathleen; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20040927. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Conference on State Mental Health Agencies Services Research, Program Evaluation, and Policy, 13th, Feb, 2003, US. Conference Note: Data from this article were presented at the aforementioned conference. Major Descriptor: Advocacy; Intervention; Mental Disorders; Mental Health Services; Parents. Minor Descriptor: Health Personnel Attitudes; Parent Child Relations. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Intergovernmental Relations' Index of Fiscal Comfort. Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: Sep, 2004.
AB - The majority of adults with serious mental illness living in the community are parents, many of whom may be receiving services from State Mental Health Authorities (SMHA). Innovative intervention approaches are available to improve outcomes for these parents and their children. Analyses of SMHA and state-level data, as well as qualitative interviews of administrators, service providers, and consumers, underscore the importance of organizational structure and philosophy, an advocacy presence, and available funding to SMHA efforts on behalf of parents and their families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health authority responsiveness
KW - State Mental Health Authorities
KW - mentally ill parents
KW - serious mental illness
KW - advocacy
KW - intervention
KW - 2004
KW - Advocacy
KW - Intervention
KW - Mental Disorders
KW - Mental Health Services
KW - Parents
KW - Health Personnel Attitudes
KW - Parent Child Relations
KW - 2004
DO - 10.1023/B:APIH.0000039661.54974.ce
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18264-003&site=ehost-live&scope=site
UR - Kathleen.Biebel@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18264-004
AN - 2004-18264-004
AU - Manderscheid, Ronald W.
AU - Henderson, Marilyn J.
T1 - Mental Health, United States, 2002 Executive Summary.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2004/09//
VL - 32
IS - 1
SP - 49
EP - 55
CY - Germany
PB - Springer
SN - 0894-587X
N1 - Accession Number: 2004-18264-004. PMID: 15527041 Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Manderscheid, Ronald W. Release Date: 20040927. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Medicaid; Mental Health; Mental Health Services; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 7. Issue Publication Date: Sep, 2004.
AB - Mental Health, United States, 2002, encompasses 21 chapters organized into six sections. Bernard Arons and colleagues (Chapter 1) describe the evolution of the Center for Mental Health Services over its first decade. Rosenthal and colleagues (Chapter 4) have developed such a typology as part of the SAMHSA initiative on Decision Support 2000+. Galea and colleagues (Chapter 7) report the results of two telephone surveys conducted in Manhattan one and four months after these events. Finkelstein and colleagues (Chapter 13) present updates of earlier estimates for payments and service use for mental health and substance abuse beneficiaries from Medicaid, Medicare, and private sector health plans. Medicaid data are from all claims for 1994 in New Jersey, Michigan, and Washington, and for 1995 in Pennsylvania. Levine and Jaffe (Chapter 15) present information on anti-psychotic medication use in a state hospital system between 1994 and 2000. Manderscheid and colleagues (Chapter 18) provide an overview of mental health organizations in 2000, together with major national and state trends. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - executive summary
KW - mental health services
KW - Center for Mental Health Services
KW - substance abuse beneficiaries
KW - Medicaid
KW - health policy
KW - 2004
KW - Medicaid
KW - Mental Health
KW - Mental Health Services
KW - Health Care Policy
KW - 2004
DO - 10.1023/B:APIH.0000039662.13491.2a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18264-004&site=ehost-live&scope=site
UR - rmanders@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23634-005
AN - 2006-23634-005
AU - Kennedy, Cheryl
AU - Finkelstein, Norma
AU - Hutchins, Ellen
AU - Mahoney, Jeanne
T1 - Improving Screening for Alcohol Use During Pregnancy: The Massachusetts ASAP Program.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2004/09//
VL - 8
IS - 3
SP - 137
EP - 147
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Kennedy, Cheryl, Institute for Health and Recovery, 349 Broadway, Cambridge, MA, US, 02139
N1 - Accession Number: 2006-23634-005. PMID: 15503394 Partial author list: First Author & Affiliation: Kennedy, Cheryl; Institute for Health and Recovery, Cambridge, MA, US. Release Date: 20070122. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Drug Abuse Prevention; Drug Usage Screening; Intervention; Prenatal Exposure. Minor Descriptor: Pregnancy; Health Personnel. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Location: US. Tests & Measures: 5P's Screening Tool. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 2004.
AB - Objective: To motivate prenatal care staff in public and private settings to universally screen for risk of alcohol and drug use and to conduct a brief intervention with follow-up referral when appropriate during a routine office visit. Methods: The ASAP Project methods were engagement of site staff; staff training; self-administered questionnaires embedded with a relational and broad catch screening tool; a brief intervention protocol; unique clinical decision tree/protocols for each site; identification of treatment and referral resources; and ongoing technical assistance and consultation. Sites were located in four regions of the state and included four community health centers, a network of multi-specialty private practices and a teaching hospital. Results: Across 16 sites, 118 prenatal staff were trained on use of the screening tool and 175 staff on the brief intervention. The ASAP Project resulted in 95% of pregnant women being screened for alcohol use and 77% of those screening positive for at least one risk factor receiving a brief intervention during a routine office visit. Conclusions: Screening and brief interventions for alcohol use can be delivered effectively within a routine prenatal care visit by prenatal staff by utilizing and building on existing office systems with practice staff, screening for any use not only at risk use, providing training with skills building sessions and information delivered by physicians, offering easy-to-access community treatment resources, and providing ongoing technical assistance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prenatal screening
KW - alcohol use
KW - substance use
KW - pregnancy
KW - brief intervention
KW - prenatal health
KW - drug abuse prevention
KW - prenatal staff
KW - 2004
KW - Alcohol Abuse
KW - Drug Abuse Prevention
KW - Drug Usage Screening
KW - Intervention
KW - Prenatal Exposure
KW - Pregnancy
KW - Health Personnel
KW - 2004
U1 - Sponsor: U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, US. Grant: H51MC011. Other Details: Grant to the Massachusetts Department of Public Health, Bureau of Family and Community Health.. Recipients: No recipient indicated
DO - 10.1023/B:MACI.0000037647.78420.e3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23634-005&site=ehost-live&scope=site
UR - cherylkennedy@healthrecovery.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04238-003
AN - 2005-04238-003
AU - Jones, Wanda K.
T1 - Men's health as a public health issue.
JF - Journal of Men's Health & Gender
JO - Journal of Men's Health & Gender
JA - J Mens Health Gend
Y1 - 2004/09//
VL - 1
IS - 2-3
SP - 147
EP - 149
CY - Netherlands
PB - Elsevier Science
SN - 1571-8913
AD - Jones, Wanda K.
N1 - Accession Number: 2005-04238-003. Other Journal Title: Journal of Men's Health. Partial author list: First Author & Affiliation: Jones, Wanda K.; US Department of Health and Human Services, Washington, DC, US. Other Publishers: Andrew John Publishing; Mary Ann Liebert, Inc. Release Date: 20050705. Correction Date: 20150720. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Conference Information: National Men's Health Conference, May, 2004, Arlington, VA, US. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Brain; Health; Human Sex Differences; Mental Health; Physiology. Minor Descriptor: Public Health. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. References Available: Y. Page Count: 3. Issue Publication Date: Sep, 2004.
AB - This editorial discusses the revelations through the past quarter century's focus on women's health, of new examples of fundamental differences between men and women, beyond their reproductive tracts. Basic physiological differences between men and women can influence their reactions to drugs. The structure of the brain and the way it functions is different in women and men. Given these differences in brain function, we should not be surprised to see sex differences manifest in mental health. We continue to benefit from collecting data on diseases, behaviors and conditions that affect our health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mens health
KW - public health issue
KW - women's health
KW - physiological differences
KW - sex differences
KW - brain function
KW - mental health
KW - 2004
KW - Brain
KW - Health
KW - Human Sex Differences
KW - Mental Health
KW - Physiology
KW - Public Health
KW - 2004
DO - 10.1016/j.jmhg.2004.07.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04238-003&site=ehost-live&scope=site
UR - wjones@osophs.dhhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23634-009
AN - 2006-23634-009
AU - van Dyck, Peter
AU - Kogan, Michael D.
AU - Heppel, David
AU - Blumberg, Stephen J.
AU - Cynamon, Marcie L.
AU - Newacheck, Paul W.
T1 - The National Survey of Children's Health: A New Data Resource.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2004/09//
VL - 8
IS - 3
SP - 183
EP - 188
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Kogan, Michael D., Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2006-23634-009. PMID: 15499874 Partial author list: First Author & Affiliation: van Dyck, Peter; Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20070122. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Care Services; Health Care Utilization; Special Needs; Surveys. Minor Descriptor: Health Insurance; Needs Assessment. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 2004.
AB - Context: Federal and state maternal and child health programs are responsible for promoting and improving the health and well-being of children. To support achievement of this goal, the federal Maternal and Child Health Bureau (MCHB) in partnership with the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention has developed a new survey that will provide uniform national and state data on the health and well-being of children, as well as the characteristics of their families and neighborhoods. Purpose: The National Survey of Children's Health was designed to produce reliable and representative state- and national-level estimates for Healthy People 2010 national prevention objectives, for each state's Title V needs assessment, and for Title V program planning and evaluation. In addition, it will provide a new data resource for researchers, advocacy groups, and other interested parties. It is anticipated that this survey will be repeated periodically, making trend analysis possible. Methods: This survey was conducted using the State and Local Area Integrated Telephone Survey (SLAITS) mechanism, which shares the random-digit-dial sampling frame of the National Immunization Survey (sponsored by the National Immunization Program and NCHS). Using the SLAITS platform, interviews on approximately 2000 children were conducted in each state and the District of Columbia. The parent or guardian most knowledgeable about the child completed a battery of questions on health and development, health insurance coverage, access to care, utilization of health care services, presence of a medical home, family functioning, parental health, and neighborhood characteristics. Data collection began in January 2003 and continued through April 2004. Summary reports and electronic data files will be available to the public by early 2005. Conclusion: This is the second state and national survey jointly completed by MCHB and NCHS. It is designed to complement the 2001 National Survey of Children with Special Health Care Needs by providing data on the health of the general child population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child health
KW - children with special needs
KW - health care utilization
KW - health insurance
KW - health care access
KW - needs assessment
KW - national survey
KW - 2004
KW - Health
KW - Health Care Services
KW - Health Care Utilization
KW - Special Needs
KW - Surveys
KW - Health Insurance
KW - Needs Assessment
KW - 2004
DO - 10.1023/B:MACI.0000037693.09847.f6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23634-009&site=ehost-live&scope=site
UR - mkogan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-22045-009
AN - 2004-22045-009
AU - Reynolds, Brady
AU - Schiffbauer, Ryan M.
T1 - Impulsive Choice and Workplace Safety: A New Area of Inquiry for Research in Occupational Settings.
JF - The Behavior Analyst
JO - The Behavior Analyst
JA - Behav Anal
Y1 - 2004///Fal 2004
VL - 27
IS - 2
SP - 239
EP - 246
CY - US
PB - Assn for Behavior Analysis
SN - 0738-6729
SN - 2196-8918
AD - Reynolds, Brady, Research Institute on Addictions, University at Buffalo, State University of New York, 1021 Main Street, Buffalo, NY, US, 14203
N1 - Accession Number: 2004-22045-009. PMID: 22478432 Partial author list: First Author & Affiliation: Reynolds, Brady; National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Assn for Behavior Analysis International; Springer. Release Date: 20050110. Correction Date: 20140113. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Choice Behavior; Employee Attitudes; Health Behavior; Impulsiveness; Occupational Safety. Minor Descriptor: Occupational Stress; Sleep Deprivation. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Fal 2004.
AB - A conceptual argument is presented for the relevance of behavior-analytic research on impulsive choice to issues of occupational safety and health. Impulsive choice is denned in terms of discounting, which is the tendency for the value of a commodity to decrease as a function of various parameters (e.g., having to wait or expend energy to receive the commodity). A high degree of discounting is often considered an index of impulsivity. We argue that for workers, possible negative consequences (e.g., injury or disease) are often disregarded, or discounted, in choices about workplace safety because such consequences are typically delayed and uncertain. Furthermore, some evidence suggests that certain environmental conditions, such as those that lead to stress or sleep deprivation, may increase discounting. Increased discounting, by extension, leads to a further devaluation of safety practices and their benefits. A call is made for research aimed at more clearly delineating the relation between impulsive choice and workplace safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - impulsive choice
KW - occupational safety
KW - stress
KW - sleep deprivation
KW - discounting
KW - employee attitude
KW - health attitude
KW - 2004
KW - Choice Behavior
KW - Employee Attitudes
KW - Health Behavior
KW - Impulsiveness
KW - Occupational Safety
KW - Occupational Stress
KW - Sleep Deprivation
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-22045-009&site=ehost-live&scope=site
UR - breynold@ria.buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19925-007
AN - 2004-19925-007
AU - Harrow, Brooke S.
AU - Mahoney, Diane F.
AU - Mendelsohn, Aaron B.
AU - Ory, Marcia G.
AU - Coon, David W.
AU - Belle, Steven H.
AU - Nichols, Linda O.
T1 - Variation in cost of informal caregiving and formal-service use for people with Alzheimer's disease.
JF - American Journal of Alzheimer's Disease and Other Dementias
JO - American Journal of Alzheimer's Disease and Other Dementias
JA - Am J Alzheimers Dis Other Demen
Y1 - 2004/09//Sep-Oct, 2004
VL - 19
IS - 5
SP - 299
EP - 308
CY - US
PB - Prime National Publishing
SN - 1533-3175
SN - 1938-2731
N1 - Accession Number: 2004-19925-007. PMID: 15553986 Other Journal Title: American Journal of Alzheimer's Disease. Partial author list: First Author & Affiliation: Harrow, Brooke S.; College of Nursing and Health Sciences, University of Massachusetts, Boston, MA, US. Other Publishers: Sage Publications. Release Date: 20041101. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alzheimer's Disease; Caregivers; Community Facilities; Costs and Cost Analysis; Home Care. Minor Descriptor: Health Care Costs; Regional Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep-Oct, 2004.
AB - This study used a geographically diverse sample to estimate the total cost of informal care and formal services for community-residing Alzheimer's disease (AD) care recipients. Baseline data were used for 1200 family caregivers from the Resources for Enhancing Alzheimer's Caregiver Health (REACH) study, a multisite intervention trial. The replacement-wage-rate approach estimated informal cost. Formal services were assigned a cost based on secondary sources. Annual cost per care recipient amounted to $23,436 for informal care and $8,064 for formal services. Variation in informal cost was almost entirely due to instrumental activities of daily living (lADLs) assistance. Cross-site differences in cost persisted after controlling for caregiver and care-recipient characteristics. Geographic variation may suggest regional preferences or ethnic/cultural values. Further study is needed to determine whether this reflects differences in access or availability or how including a control group for care recipients with nondementia diagnoses might have affected these findings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - caregiving costs
KW - total cost
KW - formal-service use
KW - Alzheimer's disease
KW - informal care
KW - community-residing patients
KW - care recipients
KW - geographic variation
KW - 2004
KW - Alzheimer's Disease
KW - Caregivers
KW - Community Facilities
KW - Costs and Cost Analysis
KW - Home Care
KW - Health Care Costs
KW - Regional Differences
KW - 2004
DO - 10.1177/153331750401900507
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19925-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20579-013
AN - 2004-20579-013
AU - Smith, Shelagh
AU - Glik, Deborah
T1 - Review of Evaluating Health Promotion Programs.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2004/09//Sep-Oct, 2004
VL - 28
IS - 5
SP - 475
EP - 478
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Smith, Shelagh, Center for Mental Health Services, Substance Abuse & Mental Health Services Administration (SAMHSA), 5600 Fishers Lane, Rom 15-87, Rockville, MD, US
N1 - Accession Number: 2004-20579-013. Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Smith, Shelagh; Center for Mental Health Services, Substance Abuse & Mental Health Services Administration (SAMHSA), Rockville, MD, US. Release Date: 20050110. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Health; Health Education; Health Promotion; Program Evaluation. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Reviewed Item: Valente, Thomas W. Evaluating Health Promotion Programs=Oxford University Press, Inc., Publishers, New York, NY 10016, 2002, xviii + 305 pp, $47.95, hardcover; 2002. Page Count: 4. Issue Publication Date: Sep-Oct, 2004.
AB - Reviews the book 'Evaluating Health Promotion Programs,' (2002) by Thomas W. Valente. The book is not nearly so mystifying or quirky. For the most part, it is clearly written, concise, useful, and covers a lot of ground. The author is able to describe complex concepts clearly with nice detail. The author is an expert in communications, network analysis, diffusion, and evaluation; and he takes obvious delight in his field. The book is primarily a textbook for students of health communications or program evaluation research, but could be used as a practitioner's reference, or for multiple purposes and audiences, because each of the 3 major sections has various levels of depth, detail, and difficulty. The author has written a book that is a strong contribution to the growing literature on evaluation and 'provides information that will help evaluators improve their skills, exercise their talents and increase their chances of conducting a successful evaluation.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - program evaluation research
KW - health promotion programs
KW - health communications
KW - 2004
KW - Health
KW - Health Education
KW - Health Promotion
KW - Program Evaluation
KW - 2004
U2 - Valente, Thomas W. (2002); Evaluating Health Promotion Programs; Oxford University Press, Inc., Publishers, New York, NY 10016, 2002, xviii + 305 pp, $47.95, hardcover
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20579-013&site=ehost-live&scope=site
UR - dglik@ucla.edu
UR - ssmith@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-01267-008
AN - 2005-01267-008
AU - Zayas, Luis H.
AU - McKee, M. Diane
AU - Jankowski, Katherine R. B.
T1 - Adapting Psychosocial Intervention Research to Urban Primary Care Environments: A Case Example.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2004/09//Sep-Oct, 2004
VL - 2
IS - 5
SP - 504
EP - 508
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Zayas, Luis H., Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, One Brookings Drive, Campus Box 1196, St. Louis, MO, US, 63130-4899
N1 - Accession Number: 2005-01267-008. PMID: 15506589 Partial author list: First Author & Affiliation: Zayas, Luis H.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20050822. Correction Date: 20130520. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Intervention; Perinatal Period; Postpartum Depression; Primary Health Care. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Beck Depression Inventory–II DOI: 10.1037/t00742-000; Life Events Questionnaire; SF-36 Health Survey; Norbeck Social Support Questionnaire. Methodology: Empirical Study. References Available: Y. Page Count: 5. Issue Publication Date: Sep-Oct, 2004.
AB - Purpose: We wanted to describe the unique issues encountered by our research team in testing an intervention to reduce perinatal depression in real-world community health centers. Method: We used a case study of an experience in conducting a randomized controlled trial designed to test the effectiveness of a low-cost multimodal psychosocial intervention to reduce prenatal and postpartum depression. Low-income minority women (N = 187) with low-risk pregnancies were randomly assigned to the intervention or treatment as usual. Outcomes of interest were depressive symptoms and social support assessed at 3 months' postpartum. Results: Our intervention was not associated with changes in depressive symptoms or social support. Challenges in implementation were related to participant retention and intervention delivery. Turnover of student therapists affected continuity in participant-therapist relationships and created missed opportunities to deliver the intervention. The academic-community partnership that was formed also required more involvement of health center personnel to facilitate ownership at the site level, especially for fidelity monitoring. While attentive to cultural sensitivity, the project called for more collaboration with participants to define common goals and outcomes. Participatory research strategies could have anticipated barriers to uptake of the intervention and achieved a better match between outcomes desired by researchers and those of participants. Conclusion: Several criteria for future research planning emerged: assessing what the population is willing and able to accept, considering what treatment providers can be expected to implement, assessing the setting's capacity to accommodate intervention research, and collecting and using emerging unanticipated data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial intervention testing
KW - low income minority subjects
KW - primary care
KW - perinatal depression
KW - research issues
KW - 2004
KW - Experimentation
KW - Intervention
KW - Perinatal Period
KW - Postpartum Depression
KW - Primary Health Care
KW - 2004
DO - 10.1370/afm.108
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01267-008&site=ehost-live&scope=site
UR - lzayas@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21331-001
AN - 2004-21331-001
AU - Yawn, Barbara P.
AU - Fryer, George E.
AU - Lanier, David
T1 - Asthma Severity: The Patient's Perspective.
JF - Journal of Asthma
JO - Journal of Asthma
JA - J Asthma
Y1 - 2004/09//
VL - 41
IS - 6
SP - 623
EP - 630
CY - United Kingdom
PB - Taylor & Francis
SN - 0277-0903
SN - 1532-4303
AD - Yawn, Barbara P., Department of Research, Olmsted Medical Center, 210 Ninth St. SE, Rochester, MN, US, 55904
N1 - Accession Number: 2004-21331-001. PMID: 15584311 Other Journal Title: Journal of Asthma Research. Partial author list: First Author & Affiliation: Yawn, Barbara P.; Department of Research, Olmsted Medical Center, Rochester, MN, US. Other Publishers: Informa Healthcare. Release Date: 20050425. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Asthma; Child Psychiatry; Client Attitudes; Self-Evaluation; Severity (Disorders). Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2004.
AB - Background: Although asthma is a common condition, limited epidemiological data exists on the distribution or course of asthma severity. We know even less about how patients or parents rate the severity of their or their child's asthma or what factors they associate with more severe asthma. A large nationally diverse sample of asthma patients' self-assessment of severity is available but has not been analyzed to look at asthma severity from the patients' perspective. Method: Data from the 'household' and 'event' files from the 1999 Medical Expenditure Panel Survey were combined to obtain a distribution of patient-reported asthma severity and the health care utilization, medication usage, and personal characteristics associated with different levels of self-reported severity for that subgroup that answered the chronic disease portion of the survey. Results: Almost two thirds of patients (63% of adults) or parents (65% of children) described their or their child's asthma as very or somewhat serious. Among both children and adults, more severe asthma was associated with greater numbers of missed school and workdays, and lower overall health status. The associated differences in health utilization varied by age. Models of severity based on available NAEPP criteria explained less than 10% of the participant's variation in self-reported asthma severity. Conclusion: Parents and patients with asthma appear to use different metrics than physicians and researchers to define the more severe categories of asthma. This disparity suggests the need for an asthma measure that is more widely understood, and accepted by patients and clinicians to serve as a tool to improve asthma-related communications and the achievement of mutually determined therapy goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - asthma severity
KW - patient perspective
KW - self-assessment
KW - 2004
KW - Asthma
KW - Child Psychiatry
KW - Client Attitudes
KW - Self-Evaluation
KW - Severity (Disorders)
KW - 2004
DO - 10.1081/JAS-200026403
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21331-001&site=ehost-live&scope=site
UR - yawnX002@umn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18509-001
AN - 2004-18509-001
AU - Primm, Benny J.
AU - Perez, Lucille
AU - Dennis, Gary C.
AU - Benjamin, Lennette
AU - Clark, H. Westley
AU - Keough, Kathy
AU - Leak, W. David
AU - Payne, Richard
AU - Smith, Deborah
AU - Sullivan, Louis W.
T1 - Managing Pain: The Challenge in Underserved Populations: Appropriate Use versus Abuse and Diversion.
JF - Journal of the National Medical Association
JO - Journal of the National Medical Association
JA - J Natl Med Assoc
Y1 - 2004/09//
VL - 96
IS - 9
SP - 1152
EP - 1161
CY - US
PB - National Medical Assn
SN - 0027-9684
SN - 1943-4693
N1 - Accession Number: 2004-18509-001. PMID: 15481743 Partial author list: First Author & Affiliation: Primm, Benny J.; Research and Treatment Corp., Brooklyn, NY, US. Other Publishers: Elsevier Science. Release Date: 20050314. Correction Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Managing Pain: The Challenge in Underserved Populations: Appropriate Use versus Abuse and Diversion Consensus Meeting, Jul, 2002, Washington, DC, US. Major Descriptor: At Risk Populations; Drug Abuse; Drug Usage; Epidemiology; Pain Management. Minor Descriptor: Minority Groups. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2004.
AB - ISSUE: Inadequate pain management is a serious public health problem that affects a wide cross-section of Americans. Patients are often denied sufficient medication, because physicians lack training and fear scrutiny from federal and state regulatory agencies. In addition, even the state-financed system of care, Medicaid, has been increasingly denying payment for the best treatment for pain management. These factors are complicated by physician bias about various subgroups and poor physicianpatient communication. Comprehensive patient assessment plays a crucial role in determining appropriate treatment and identifying potential abuse problems. Physicians must routinely document medications analgesic effects and screen for potential ill effects and drug abuse. OBJECTIVE: To examine the prevalence of the undertreatment of pain, particularly among African Americans, and to recommend relevant proactive policy and practice changes to aid in eliminating this health problem. CONSENSUS PROCESS: In July 2002, the NMA convened the 'Managing Pain: The Challenge in Underserved Populations: Appropriate Use versus Abuse and Diversion' Consensus Meeting in Washington, DC. The country's most renowned experts in the area of pain management and substance abuse reviewed substantial information regarding pain management and substance abuse including the following: A draft summary paper on pain management and substance abuse that served as briefing material for consensus members; Annotated bibliographies; Articles on pain management and substance abuse; and Key presentations on pain management and substance abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - healthcare provider
KW - pain management
KW - underserved populations
KW - drug abuse
KW - drug use
KW - diversion
KW - 2004
KW - At Risk Populations
KW - Drug Abuse
KW - Drug Usage
KW - Epidemiology
KW - Pain Management
KW - Minority Groups
KW - 2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18509-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Bryan, Wilson
T1 - Regulatory issues in ALS clinical trials.
JO - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
Y1 - 2004/09/02/Sep2004 Supplement 1
VL - 5
M3 - Article
SP - 36
EP - 41
PB - Taylor & Francis Ltd
SN - 14660822
AB - Focuses on the regulatory issue on the clinical trials of amyotrophic lateral sclerosis drugs. Necessity of clinical trial to investigate issues related to safety and efficacy to provide critical information to future drug development; Means to guide the design of subsequent clinical trials; Stages of drug development.
KW - MEDICAL research
KW - CLINICAL trials
KW - CLINICAL medicine
KW - DRUG development
KW - AMYOTROPHIC lateral sclerosis -- Treatment
KW - DRUGS -- Effectiveness
N1 - Accession Number: 14664838; Bryan, Wilson 1; Affiliation: 1: US Food and Drug Administration Maryland; Source Info: Sep2004 Supplement 1, Vol. 5, p36; Subject Term: MEDICAL research; Subject Term: CLINICAL trials; Subject Term: CLINICAL medicine; Subject Term: DRUG development; Subject Term: AMYOTROPHIC lateral sclerosis -- Treatment; Subject Term: DRUGS -- Effectiveness; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/17434470410015964
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14664838&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walton, Marc
T1 - Use of surrogate markers.
JO - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders
Y1 - 2004/09/02/Sep2004 Supplement 1
VL - 5
M3 - Article
SP - 103
EP - 103
PB - Taylor & Francis Ltd
SN - 14660822
AB - Comments on the efficacy of the use of surrogates. Relevance of surrogate endpoints during clinical development; Ability to be used as the basis of approval; Likelihood to predict clinical benefit.
KW - MEDICAL sciences
KW - LIFE sciences
KW - BIOLOGY
KW - SCIENCE
KW - LIFE (Biology)
N1 - Accession Number: 14664821; Walton, Marc 1; Affiliation: 1: Director, Division of Therapeutic Biological Internal Medicine Products, Center for Drug Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852; Source Info: Sep2004 Supplement 1, Vol. 5, p103; Subject Term: MEDICAL sciences; Subject Term: LIFE sciences; Subject Term: BIOLOGY; Subject Term: SCIENCE; Subject Term: LIFE (Biology); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1p; Document Type: Article
L3 - 10.1080/17434470410019834
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14664821&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petricoin, Emanuel F.
AU - Zoon, Kathryn C.
AU - Kohn, Elise C.
AU - Barrett, J. Carl
AU - Liotta, Lance A.
T1 - CLINICAL PROTEOMICS: TRANSLATING BENCHSIDE PROMISE INTO BEDSIDE REALITY.
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
Y1 - 2004/09/02/Sep2004 Supplement
VL - 5
M3 - Article
SP - 20
EP - 32
PB - Nature Publishing Group
SN - 14710056
AB - Describes proteomic technologies that are being developed to detect cancer, to discover the next generation of targets and imaging biomarkers and to tailor the therapy to cancer patients. Classification of cancer as a proteomic disease; Application of proteomics in cancer diagnosis; Potential of proteomics to treat and manage cancer; Future of clinical proteomics. INSETS: Box 1 Proteomic pattern diagnostics;Box 2 Laser-capture microdissection.
KW - PROTEOMICS
KW - MOLECULAR biology
KW - CANCER -- Diagnosis
KW - CANCER treatment
KW - CANCER patients
KW - THERAPEUTICS
N1 - Accession Number: 14637739; Petricoin, Emanuel F. 1; Email Address: petricoin@cber.fda.gov Zoon, Kathryn C. 2 Kohn, Elise C. 3 Barrett, J. Carl 3 Liotta, Lance A. 4; Affiliation: 1: FDA-NCI Clinical Proteomics Program, Division of Therapeutic Proteins, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA 2: Office of the Director, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA 3: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 4: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; Source Info: Sep2004 Supplement, Vol. 5, p20; Subject Term: PROTEOMICS; Subject Term: MOLECULAR biology; Subject Term: CANCER -- Diagnosis; Subject Term: CANCER treatment; Subject Term: CANCER patients; Subject Term: THERAPEUTICS; Number of Pages: 13p; Illustrations: 11 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1038/nrd891
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14637739&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Binienda, Zbigniew
AU - Virmani, Ashraf
AU - Przybyla-Zawislak, Beata
AU - Schmued, Larry
T1 - Neuroprotective effect of l-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2004/09/02/
VL - 367
IS - 2
M3 - Article
SP - 264
EP - 267
SN - 03043940
AB - A plant and fungal toxin, 3-NPA, acts as an inhibitor of mitochondrial function via irreversible inactivation of the mitochondrial inner membrane enzyme, succinate dehydrogenase (SDH). Inhibition of SDH disturbs electron transport and leads to cellular energy deficits and neuronal injury. We have shown that pretreatment with l-carnitine, while not significantly attenuating SDH inhibition, prevented hypothermia and oxidative stress-associated increased activity of free radical-scavenging enzymes. Here, a neurohistological method was applied to examine the effect of carnitine pretreatment against 3-NPA-induced neurotoxicity. Twenty adult male Sprague–Dawley rats were randomly divided into two groups (n = 10/group). Rats in the first group were injected twice with 3-NPA at 30 mg/kg s.c., 2 days apart, and the second group of animals received l-carnitine pretreatment at 100 mg/kg 30–40 min before 3-NPA administration. Rats in both groups were perfused 7 days later and their brains harvested. Degenerating neurons were identified and localized via the fluorescent marker Fluoro-Jade B. In the three animals that survived 3-NPA dosing, one exhibited no pathology, one exhibited moderate unilateral damage to the striatum, and the third exhibited extensive bilateral neuronal degeneration in multiple forebrain regions. In the seven surviving animals that received l-carnitine prior to 3-NPA insult, six exhibited no lesions, while one exhibited a modest unilateral lesion in the striatum. It appears that l-carnitine is protective against 3-NPA-induced toxicity, as reflected by both reduced mortality and significantly reduced neuronal degeneration. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXICOLOGY
KW - RATS
KW - PREVENTIVE medicine
KW - HYPOTHERMIA
KW - 3-Nitropropionic acid
KW - Fluoro-Jade B
KW - l-Carnitine
KW - Neuroprotection
KW - Rat
KW - Striatum
N1 - Accession Number: 14250071; Binienda, Zbigniew 1; Email Address: zbinienda@nctr.fda.gov Virmani, Ashraf 2 Przybyla-Zawislak, Beata 1 Schmued, Larry 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 2: Research and Development, Sigma tau-HealthScience, Pomezia 00040, Italy; Source Info: Sep2004, Vol. 367 Issue 2, p264; Subject Term: NEUROTOXICOLOGY; Subject Term: RATS; Subject Term: PREVENTIVE medicine; Subject Term: HYPOTHERMIA; Author-Supplied Keyword: 3-Nitropropionic acid; Author-Supplied Keyword: Fluoro-Jade B; Author-Supplied Keyword: l-Carnitine; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Striatum; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neulet.2004.05.031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14250071&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Ellenberg, Susan S.
AU - Orloff, David G.
AU - Temple, Robert J.
T1 - Homocysteine as a Predictive Factor for Hip Fracture in Older Persons.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2004/09/02/
VL - 351
IS - 10
M3 - Letter
SP - 1027
EP - 1030
SN - 00284793
AB - A letter to the editor is presented in response to the article "Homocysteine as a Predictive Factor for Hip Fracture in Older Persons," by McLean, et al. in the May 13, 2004 issue.
KW - LETTERS to the editor
KW - HOMOCYSTEINE
N1 - Accession Number: 24933014; Ellenberg, Susan S. 1 Orloff, David G. 2 Temple, Robert J. 2; Affiliation: 1: . Food and Drug Administration Rockville, MD 20852 2: Food and Drug Administration Rockville, MD 20857; Source Info: 9/2/2004, Vol. 351 Issue 10, p1027; Subject Term: LETTERS to the editor; Subject Term: HOMOCYSTEINE; Number of Pages: 1p; Document Type: Letter; Full Text Word Count: 219
L3 - 10.1056/NEJM200409023511017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24933014&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106600610
T1 - Organizational research with impact: working backwards.
AU - Fraser I
Y1 - 2004/09/02/2004 Supplement 1
N1 - Accession Number: 106600610. Language: English. Entry Date: 20050401. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Supplement Title: 2004 Supplement 1. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 101185267.
KW - Health Services Research
KW - Management
KW - Professional Practice, Evidence-Based
KW - Research, Nursing
SP - S52
EP - 9
JO - Worldviews on Evidence-Based Nursing
JF - Worldviews on Evidence-Based Nursing
JA - WORLDVIEWS EVID BASED NURS
VL - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background or Rationale: To improve health care, we need to improve the organization of care, along with the payment systems that shape organizational priorities and behavior. The opportunity and challenge for research are to find a way to work with health care leadership so that future management decisions can make use of strong evidence.Aims and Methods: This article uses findings from research on nursing to illustrate the potential for organizational research and management research to improve health care. It then distills recommendations from six focused stakeholder meetings to identify five ways in which we might improve organizational, management, and policy research to maximize its use.Results and Discussion: Hospital, health plan, and other system leaders have five recommendations for research: (1) Design studies that answer user questions, with a focus on the 'why' and 'what if' rather than just the 'what.' (2) Present findings in leaders' time and space, defining evidence as they do and identifying generalizability of findings. (3) Change the incentive system for researchers so that they are rewarded for the activities that maximize impact on decision making. (4) Build user-researcher collaborations and dialogue. (5) Change the way we disseminate evidence, with dissemination through 'early adopters,' trade association meetings, consultants, etc.Implications for Research, Practice, and Policy: System and policy leaders control important levers for improving health care, since they shape organizational structure, processes and culture, payment strategies, program design, and regulation. Just as evidence-based medicine can improve clinical practice, evidence-based management and policymaking can change how these powerful levers are used. But for evidence to inform the decisions of system and policy leaders, we will need to rethink and restructure the research enterprise itself, bringing the potential users of evidence into the production process.
SN - 1545-102X
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; ifraser@ahrq.gov
DO - 10.1111/j.1524-475X.2004.04044.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106600610&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106600615
T1 - Translation research: where do we go from here?
AU - Fraser I
Y1 - 2004/09/02/2004 Supplement 1
N1 - Accession Number: 106600615. Language: English. Entry Date: 20050401. Revision Date: 20150818. Publication Type: Journal Article. Supplement Title: 2004 Supplement 1. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 101185267.
KW - Health Services Research
KW - Professional Practice, Evidence-Based
KW - Health Care Delivery
KW - Organizational Change
SP - S78
EP - 83
JO - Worldviews on Evidence-Based Nursing
JF - Worldviews on Evidence-Based Nursing
JA - WORLDVIEWS EVID BASED NURS
VL - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Aim: Where do we go from here? This article draws on other articles in this supplement, the dialogue from the meeting that generated it, and other sources to identify steps to advance translation research, and in particular to achieve broader translation and use of evidence.Implications: To move from the growing accumulation of individual successes in translation to broader scale translation and implementation of evidence, those who use research and those who do research will need to do four things: (1) increase synergy and synchronization across studies, through cross-disease studies, adoption of a common and precise language to describe interventions, addressing issues of customization of interventions, and finding commonality in quality and outcomes measures; (2) take account of organizational factors that can shape the impact of interventions, and also move to the implementation of organizational evidence; (3) address environmental factors such as reimbursement and market competition; and (4) take findings to a larger scale through national demonstrations, efforts of national agents of change, challenge or partnership grants, or use of provider-based networks.
SN - 1545-102X
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; ifraser@ahrq.gov
DO - 10.1111/j.1524-475X.2004.04046.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106600615&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roscoe, R. J.
AU - Graydon, J. R.
T1 - Adult Blood Lead Epidemiology and Surveillance--United States, 2002.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/09/08/
VL - 292
IS - 10
M3 - Article
SP - 1169
EP - 1171
SN - 00987484
AB - Offers a look at the United States Centers for Disease Control and Prevention's state-based Adult Blood Lead Epidemiology and Surveillance program. Report that in 2002, approximately 95 percent of adult lead exposures were occupational; Importance of prevention activities, particularly in work environments, to achieve the 2010 health objective.
KW - LEAD in the body
KW - INDUSTRIAL hygiene
KW - ENVIRONMENTAL health
KW - OCCUPATIONAL diseases
KW - WORK environment
KW - PUBLIC health
KW - UNITED States
KW - Environmental Exposure
KW - FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
KW - Lead
KW - Occupational Exposure
N1 - Accession Number: 14358271; Roscoe, R. J. 1 Graydon, J. R. 1; Affiliation: 1: National Institute for Occupational Safety and Health; Source Info: 9/8/2004, Vol. 292 Issue 10, p1169; Subject Term: LEAD in the body; Subject Term: INDUSTRIAL hygiene; Subject Term: ENVIRONMENTAL health; Subject Term: OCCUPATIONAL diseases; Subject Term: WORK environment; Subject Term: PUBLIC health; Subject Term: UNITED States; Author-Supplied Keyword: Environmental Exposure; Author-Supplied Keyword: FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION; Author-Supplied Keyword: Lead; Author-Supplied Keyword: Occupational Exposure; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14358271&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hierro, Aitor
AU - Ji Sun
AU - Rusnak, Alexander S.
AU - Kim, Jaewon
AU - Prag, Gali
AU - Emr, Scott D.
AU - Hurley, James H.
T1 - Structure of the ESCRT-II endosomal trafficking complex.
JO - Nature
JF - Nature
Y1 - 2004/09/09/
VL - 431
IS - 7005
M3 - Article
SP - 221
EP - 225
PB - Nature Publishing Group
SN - 00280836
AB - The multivesicular-body (MVB) pathway delivers transmembrahe proteins and lipids to the lumen of the endosome. The multivesicular-body sorting pathway has crucial roles in growth-factor-receptor downregulatlon1, developmental signalling2-4, regulation of the immune response5 and the budding of certain enveloped viruses such as human immunodeficiency virus6. Ubiquitination is a signal for sorting into the MVB pathway7,8, which also requires the functions of three protein complexes, termed ESCRT-I, -II and -HI (endosomal sorting complex required for transport)7,9,10. Here we report the crystal structure of the core of the yeast ESCRT-II complex, which contains one molecule of the Vim protein Vps22, the carboxy-terminal domain of Vps36 and two molecules of Vps25, and has the shape of a capital letter ‘Y’. The amino-terminal coiled coil of Vps22 and the flexible linker leading to the ubiquitin-binding NZF domain of Vps36 both protrude from the tip of one branch of the ‘Y’. Vps22 and Vps36 form neatly equivalent interactions with the two Vps25 molecules at the centre of the ‘Y’. The structure suggests how ubiquitinated cargo could be passed between ESCRT components of the MVB pathway through the sequential transfer of ubiquitinated cargo from one complex to the next. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - LIPIDS
KW - GROWTH factors
KW - IMMUNE response
KW - HIV (Viruses)
KW - AMINO acids
N1 - Accession Number: 14396902; Hierro, Aitor 1 Ji Sun 2 Rusnak, Alexander S. 2 Kim, Jaewon 1 Prag, Gali 1 Emr, Scott D. 2 Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892-0580, USA 2: Department of Cellular and Molecular Medicine and Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0668, USA; Source Info: 9/9/2004, Vol. 431 Issue 7005, p221; Subject Term: PROTEINS; Subject Term: LIPIDS; Subject Term: GROWTH factors; Subject Term: IMMUNE response; Subject Term: HIV (Viruses); Subject Term: AMINO acids; Number of Pages: 5p; Document Type: Article
L3 - 10.1038/nature02914
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14396902&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shinoda, Kaori
AU - Xin, Ke-Qin
AU - Jounai, Nao
AU - Kojima, Yoshitsugu
AU - Tamura, Yuichi
AU - Okada, Eiichi
AU - Kawamoto, Susumu
AU - Okuda, Katsuji
AU - Klinman, Dennis
AU - Okuda, Kenji
T1 - Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
JO - Vaccine
JF - Vaccine
Y1 - 2004/09/09/
VL - 22
IS - 27/28
M3 - Article
SP - 3676
EP - 3690
SN - 0264410X
AB - Single HIV-1 subtype DNA vaccine is unlikely to provide reactive protection across a wide range of HIV strains since the HIV virus changes the antigenic sites, particularly, in env gene. To overcome these issues, we constructed a multivalent poly-epitope DNA vaccine. A polygenic DNA vaccine encoding 20 antigenic epitopes from the HIV-1 Env, Gag, and Pol proteins of several clades was constructed using humanized and optimized codons and it was named here hDNA vaccine. In mice, this hDNA vaccine stimulated the following strong (1) antigen-specific serum antibody (Ab) responses, (2) delayed-type hypersensitivity, (3) the activation of IFN-γ secretion cells targeting gp120 and synthetic antigenic peptides, in addition (4) a significant level of several peptide specific cytotoxic T lymphocytes (CTL) responses. Challenged with modified vaccinia viruses vPE16 and vP1206 expressing HIV-1 env and gag·pol genes, respectively, demonstrated the viral titers in the ovary of the mice vaccinated with hDNA significantly less compared to the unvaccinated mice. Thus, the use of polygene DNA vaccine appears to induce a high level of HIV-specific immune responses and is very effective against challenge with recombinant HIV-vaccinia viruses. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - HIV (Viruses)
KW - Antigenic determinants
KW - Vaccines
KW - HIV-1
KW - Multivalent poly epitope vaccine
N1 - Accession Number: 14102408; Shinoda, Kaori 1; Xin, Ke-Qin 1; Jounai, Nao 1; Kojima, Yoshitsugu 1; Tamura, Yuichi 1; Okada, Eiichi 1; Kawamoto, Susumu 1; Okuda, Katsuji 2; Klinman, Dennis 3; Okuda, Kenji 1; Email Address: kokuda@med.yokohama-cu.ac.jp; Affiliations: 1: Department of Bacteriology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan; 2: Department of Microbiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan; 3: Division of Viral Production, Laboratory of Retrovirology and Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29A, Rm. 3D10, Bethesda, MD 20892-4555, USA; Issue Info: Sep2004, Vol. 22 Issue 27/28, p3676; Thesaurus Term: Vaccination; Thesaurus Term: HIV (Viruses); Subject Term: Antigenic determinants; Subject Term: Vaccines; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: Multivalent poly epitope vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.03.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stingley, Robin L.
AU - Khan, Ashraf A.
AU - Cerniglia, Carl E.
T1 - Molecular characterization of a phenanthrene degradation pathway in Mycobacterium vanbaalenii PYR-1
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2004/09/10/
VL - 322
IS - 1
M3 - Article
SP - 133
EP - 146
SN - 0006291X
AB - Mycobacterium vanbaalenii PYR-1 is capable of degrading a number of polycyclic aromatic hydrocarbons (PAHs) to ring cleavage metabolites via multiple pathways. Genes for the large and small subunits of a pyrene dioxygenase, nidA and nidB, respectively, were previously identified in M. vanbaalenii PYR-1 [Appl. Environ. Microbiol. 67 (2001) 3577]. A library of the M. vanbaalenii PYR-1 genome was constructed in a fosmid vector to identify additional genes involved in PAH degradation. Twelve fosmid clones containing nidA were identified by Southern hybridization. Sequence analysis of one nidA-positive clone, pFOS608, revealed a number of additional genes involved in PAH degradation. At this locus, one putative operon contained genes involved in phthalate degradation, and another contained genes encoding a putative ABC transporter(s). A number of the genes found in this region are homologous to those involved in phenanthrene degradation via the phthalic acid pathway. The majority of phenanthrene degradation genes were located between putative transposase genes. In Escherichia coli, pFOS608 converted phenanthrene into phenanthrene cis-3,4-dihydrodiol, and converted 1-hydroxy-2-naphthoic acid into 2′-carboxybenzalpyruvate, 2-carboxybenzaldehyde, and phthalic acid. A subclone containing nidA and nidB converted phenanthrene into phenanthrene cis-3,4-dihydrodiol, suggesting that the NidAB dioxygenase is responsible for an initial attack on phenanthrene. This study is the first to identify genes responsible for the degradation of phenanthrene via the phthalic acid pathway in Mycobacterium species. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENANTHRENE
KW - POLYCYCLIC aromatic hydrocarbons
KW - ENTEROBACTERIACEAE
KW - ESCHERICHIA coli
KW - Mycobacterium vanbaalenii
KW - PAH degradation
KW - Phenanthrene degradation
N1 - Accession Number: 14101028; Stingley, Robin L. 1 Khan, Ashraf A.; Email Address: ashraf@nctr.fda.gov Cerniglia, Carl E. 1; Affiliation: 1: National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Sep2004, Vol. 322 Issue 1, p133; Subject Term: PHENANTHRENE; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: ENTEROBACTERIACEAE; Subject Term: ESCHERICHIA coli; Author-Supplied Keyword: Mycobacterium vanbaalenii; Author-Supplied Keyword: PAH degradation; Author-Supplied Keyword: Phenanthrene degradation; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.bbrc.2004.07.089
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ying-Xin Fan
AU - Wong, Lily
AU - Deb, Tushar B.
AU - Johnson, Gibbes R.
T1 - Ligand Regulates Epidermal Growth Factor Receptor Kinase Specificity.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/09/10/
VL - 279
IS - 37
M3 - Article
SP - 38143
EP - 38150
SN - 00219258
AB - The epidermal growth factor receptor (EGFR) kinase catalyzes phosphorylation of tyrosines in its C terminus and in other cellular targets upon epidermal growth factor (EGF) stimulation. Here, by using peptides derived from EGFR autophosphorylation sites and cellular substrates, we tested the hypothesis that ligand may function to regulate EGFR kinase specificity by modulating the binding affinity of peptide sequences to the active site. Measurement of the steady-state kinetic parameters, Km and kcat, revealed that EGF did not affect the binding of EGFR peptides but increased the binding affinity for peptides corresponding to the major EGFR- mediated phosphorylation sites of the adaptor proteins Gab1 (Tyr-627) and Shc (Tyr-317), and for peptides containing the previously identified optimal EGFR kinase substrate sequence EEEEYFELV (3-7-fold). Conversely, EGF stimulation increased heat ∼5-fold for all peptides. Thus, ligand changed the relative preference of the EGFR kinase for substrates as evidenced by EGF increases of ∼5-fold in the specificity constants (kcat/Km) for EGFR peptides, whereas ∼15-40-fold increases were observed for other peptides, such as Gab1 Tyr-627. Furthermore, we demonstrate that EGF (i) increased the binding affinity of EGFR to Gab1 Tyr-627 and Shc Tyr- 317 sites in purified GST fusion proteins ∼4-6-fold, and (ii) EGF significantly enhanced the phosphorylation of these sites, relative to EGFR autophosphorylation, in cell lysates containing the full-length Gab1 and Shc proteins. Analysis of peptides containing amino acid substitutions indicated that residues C-terminal to the target tyrosine were critical for EGF-stimulated increases in substrate binding and regulation of kinase specificity. To our knowledge, this represents the first demonstration that ligand can alter specificity of a receptor kinase toward physiologically relevant targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMAL growth factor
KW - PROTEINS
KW - PEPTIDES
KW - CYTOKINES
KW - PHOSPHORYLATION
KW - TYROSINE
KW - AMINO acid sequence
N1 - Accession Number: 14601861; Ying-Xin Fan 1 Wong, Lily 1 Deb, Tushar B. 1 Johnson, Gibbes R. 1; Email Address: johnsong@cber.fda.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 9/10/2004, Vol. 279 Issue 37, p38143; Subject Term: EPIDERMAL growth factor; Subject Term: PROTEINS; Subject Term: PEPTIDES; Subject Term: CYTOKINES; Subject Term: PHOSPHORYLATION; Subject Term: TYROSINE; Subject Term: AMINO acid sequence; Number of Pages: 8p; Illustrations: 5 Black and White Photographs, 4 Charts, 8 Graphs; Document Type: Article
L3 - 10.1074/jbc.M405760200
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Brinker, A.
AU - Avigan, M.
T1 - Epidemiology of ischaemic colitis.
JO - Alimentary Pharmacology & Therapeutics
JF - Alimentary Pharmacology & Therapeutics
Y1 - 2004/09/15/
VL - 20
IS - 6
M3 - Letter
SP - 697
EP - 698
PB - Wiley-Blackwell
SN - 02692813
AB - Presents a letter to the editor in response to article discussing ischaemic colitis published in the previous issue of "Aliment Pharmacol Ther."
KW - LETTERS to the editor
KW - ISCHEMIC colitis
N1 - Accession Number: 14358404; Brinker, A. 1; Email Address: brinkera@cder.fda.gov Avigan, M. 1; Affiliation: 1: Food and Drug Administration, Rockville, MD 20857 USA; Source Info: Sep2004, Vol. 20 Issue 6, p697; Subject Term: LETTERS to the editor; Subject Term: ISCHEMIC colitis; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1365-2036.2004.02117.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krynitsky, Alexander J.
AU - Niemann, Richard A.
AU - Nortrup, David A.
T1 - Determination of Psrchlorate Anion in Food by ton Chromatography -- Tandem Mass Spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2004/09/15/
VL - 76
IS - 18
M3 - Article
SP - 5518
EP - 5522
SN - 00032700
AB - A rapid, sensitive, and specific method was developed for determining perchlorate anion in lettuce, cantaloupe, bottled water, and milk. A test portion of chopped crop homogenate was extracted with diluted nitric add and filtered. Milk proteins were precipitated with acetonitrile, and the supernatant, after centrifugation, was cleaned up on a graphitized carbon solid-phase extraction column. Water samples were analyzed directly. All test solutions were syringe filtered and mixed with an 18O4-labeled perchlorate internal standard before ion chromatography-tandem mass spectrometry. A strong anion exchange column eluted with 100 mM ammonium acetate in 50:50 (v/v) acetonitrile/water was interfaced via electrospray ionization to a triple stage quadrupole mass spectrometer operated in the negative ion mode. The labeled internal standard corrected for any sample matrix effects on measured signals. Four parent-to-product ion transitions, for loss of oxygen, were monitored for native and 18O4-labeled perchlorate anion, respectively: 35Cl-perchlorate, m/z 99 → 83 and 107 → 89; 37Cl-perchlorate, m/z 101 → 85 and 109 → 91. The limit of quantitation was 1.0 μg/kg in lettuce, 2.0 μg/kg in cantaloupe, 0.50 μg/L in bottled water, and 3.0 μg/L in milk. Native perchlorate was recovered from fortified test portions in the range 93-107% for lettuce, 107-114% for cantaloupe, 100-115% for bottled water, and 99-101% for milk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANION separation
KW - MILK proteins
KW - BOTTLED water
KW - PROCESSED foods
KW - ANIONS
KW - SOLID phase extraction
KW - MASS spectrometers
N1 - Accession Number: 14533660; Krynitsky, Alexander J. 1; Email Address: Alex.Krynitsky@cfsan.fda.gov Niemann, Richard A. 1 Nortrup, David A. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835.; Source Info: 9/15/2004, Vol. 76 Issue 18, p5518; Subject Term: ANION separation; Subject Term: MILK proteins; Subject Term: BOTTLED water; Subject Term: PROCESSED foods; Subject Term: ANIONS; Subject Term: SOLID phase extraction; Subject Term: MASS spectrometers; NAICS/Industry Codes: 312110 Soft drink and ice manufacturing; NAICS/Industry Codes: 312112 Bottled Water Manufacturing; NAICS/Industry Codes: 413210 Non-alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lomander, Andrea
AU - Schreuders, Paul
AU - Russek-Cohen, Estelle
AU - Ali, Laila
T1 - Evaluation of chlorines' impact on biofilms on scratched stainless steel surfaces
JO - Bioresource Technology
JF - Bioresource Technology
Y1 - 2004/09/15/
VL - 94
IS - 3
M3 - Article
SP - 275
EP - 283
SN - 09608524
AB - Biofilms of a wild type Escherichia coli were grown on 316 stainless steel slides in a nutrient starved medium. The stainless steel surfaces were either polished to a smooth finish or scribed. The scribes consisted of lines and crosses. Biofilm samples were taken after 3, 6, 12, 24 and 48 h of growth. After sampling, the slides were soaked in deionized water or 50 or 200 ppm free chlorine prior to vital staining. Images were captured and the areas of viable and total biofilm were estimated. The individual biofilm patches, circularities, total percentage coverage, and viability percentage coverage were analyzed. The biofilms tended to increase in size between 6 and 24 h. A 3–6 h old biofilm on a polished stainless steel surface detached when 200 ppm sodium hypochlorite was applied. When grown in scribes, the circularity decreased up to 24 h, but thereafter increased. As the film grew older, it detached with or without a sodium hypochlorite treatment from the part of the surface that was polished, but remained in the neighborhood of the scribe. Based on the results, we recommend sanitizing at intervals of less than 12 h for this and similar strains of bacteria and protection of stainless steel surfaces to minimize scratching. [Copyright &y& Elsevier]
AB - Copyright of Bioresource Technology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia
KW - Microbial aggregation
KW - Stainless steel
KW - Hypochlorites
KW - 316 stainless steel
KW - Biofilms
KW - Chlorine
KW - Escherichia coli
KW - Image analysis
KW - Surface morphology
N1 - Accession Number: 13327940; Lomander, Andrea 1; Schreuders, Paul 1; Email Address: ps129@umail.umd.edu; Russek-Cohen, Estelle 2; Ali, Laila 3; Affiliations: 1: Biological Resources Engineering Department, University of Maryland, College Park, MD 20742, USA; 2: Animal and Avian Sciences Department, University of Maryland, College Park, MD 20742, USA; 3: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Sep2004, Vol. 94 Issue 3, p275; Thesaurus Term: Escherichia; Thesaurus Term: Microbial aggregation; Subject Term: Stainless steel; Subject Term: Hypochlorites; Author-Supplied Keyword: 316 stainless steel; Author-Supplied Keyword: Biofilms; Author-Supplied Keyword: Chlorine; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Image analysis; Author-Supplied Keyword: Surface morphology; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.biortech.2004.01.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Liu, Teresa
AU - Zhiping Ye
T1 - Introduction of a Temperature-Sensitive Phenotype into Influenza A/WSN/33 Virus by Altering the Basic Amino Acid Domain of Influenza Virus Matrix Protein.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/09/15/
VL - 78
IS - 18
M3 - Article
SP - 9585
EP - 9591
SN - 0022538X
AB - Our previous studies with influenza A viruses indicated that the association of M1 with viral RNA and nucleoprotein (NP) is required for the efficient formation of helical ribonucleoprotein (RNP) and for the nuclear export of RNPs. RNA-binding domains of M1 map to the following two independent regions: a zinc finger motif at amino acid positions 148 to 162 and a series of basic amino acids (RKLKR) at amino acid positions 101 to 105. Altering the zinc finger motif of M1 reduces viral growth slightly. A substitution of Ser for Arg at either position 101 or position 105 of the RKLKR domain partially reduces the nuclear export of RNP and viral replication. To further understand the role of the zinc finger motif and the RKLKR domain in viral assembly and replication, we introduced multiple mutations by using reverse genetics to modify these regions of the M gene of influenza virus A/WSN/33. Of multiple mutants analyzed, a double mutant, RI01S– RI05S, of RKLKR resulted in a temperature-sensitive phenotype. The R101S–R105S double mutant had a greatly reduced ratio of M1 to NP in viral particles and a weaker binding of M1 to RNPs. These results suggest that mutations can be introduced into the RKLKR domain to control viral replication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA viruses
KW - INFLUENZA
KW - AMINO acids
KW - NUCLEOPROTEINS
KW - RNA
KW - ZINC-finger proteins
KW - VIRAL replication
N1 - Accession Number: 14584337; Liu, Teresa 1 Zhiping Ye 1; Email Address: yez@cber.fda.gov; Affiliation: 1: Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: Sep2004, Vol. 78 Issue 18, p9585; Subject Term: INFLUENZA viruses; Subject Term: INFLUENZA; Subject Term: AMINO acids; Subject Term: NUCLEOPROTEINS; Subject Term: RNA; Subject Term: ZINC-finger proteins; Subject Term: VIRAL replication; Number of Pages: 7p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.18.9585-9591.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fernabdez, Javier
AU - Taylor, Deborah
AU - Morhardt, Duncan R.
AU - Mihalik, Kathleen
AU - Puig, Montserrat
AU - Rice, Charles M.
AU - Feinstone, Stephen M.
AU - Major, Marian E.
T1 - Long-Term Persistence of Infection in Chimpanzees Inoculated with an Infectious Hepatitis C Virus Clone Is Associated with a Decrease in the Viral Amino Acid Substitution Rate and Low Levels of.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/09/15/
VL - 78
IS - 18
M3 - Article
SP - 9782
EP - 9789
SN - 0022538X
AB - Two chimpanzees, 1535 and 1536, became persistently infected following inoculation with RNA transcripts from cDNA clones of hepatitis C virus (HCV). Analysis of the HCV genomes from both animals showed an accumulation of amino acid substitutions over time. The appearance of substitutions in the envelope genes was associated with increased antienvelope antibody titers. However, extensive mutations were not incorporated into hypervariable region 1 (HVR1). A comparison of the nonsynonymous substitution rate/synonymous substitution rate was made at various time points to analyze selective pressure. The highest level of selective pressure occurred during the acute phase and decreased as the infection continued. The nonsynonymous substitution rate was initially higher than the synonymous substitution rate but decreased over time from 3.3 × 10-3 (chimpanzee 1535) and 3.2 × 10-3 (chimpanzee 1536) substitutions/site/year at week 26 to 1.4 7times; 10-3 (chimpanzee 1535) and 1.7 × 10-3 (chimpanzee 1536) at week 216, while the synonymous substitution rate remained steady at ∼1 × 10-3 substitutions/site/year. Analysis of PCR products using single-stranded conformational polymorphism indicated a low level of heterogeneity in the viral genome. The results of these studies confirm that the persistence of infection is not solely due to changes in HVR1 or heterogeneity and that the majority of variants observed in natural infections could not arise simply through mutation during the time period most humans and chimpanzees are observed. These data also indicate that immune pressure and selection continue throughout the chronic phase. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - VIRAL genomes
KW - AMINO acids
KW - GENES
KW - CHIMPANZEES
KW - FLAVIVIRUSES
N1 - Accession Number: 14584358; Fernabdez, Javier 1 Taylor, Deborah 1 Morhardt, Duncan R. 1 Mihalik, Kathleen 1 Puig, Montserrat 1 Rice, Charles M. 2 Feinstone, Stephen M. 1 Major, Marian E. 1; Email Address: major@cber.fda.gov; Affiliation: 1: Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Center for the Study of Hepatitis C, Rockefeller University, New York, New York; Source Info: Sep2004, Vol. 78 Issue 18, p9782; Subject Term: HEPATITIS C virus; Subject Term: VIRAL genomes; Subject Term: AMINO acids; Subject Term: GENES; Subject Term: CHIMPANZEES; Subject Term: FLAVIVIRUSES; Number of Pages: 8p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.18.9782-9789.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grim, Charles
T1 - Indian Health Services reorganizes with tribes' help.
JO - Federal Times
JF - Federal Times
J1 - Federal Times
PY - 2004/09/20/
Y1 - 2004/09/20/
VL - 40
IS - 32
M3 - Article
SP - 21
EP - 21
SN - 00149233
AB - Comments on the headquarters management structure reorganization undertaken by the Indian Health Service (IHS), an agency in the U.S. Health and Human Services Department. Purpose of the revised structure; Number of members being served by IHS; Changes that took effect in the reorganization.
KW - EXECUTIVE department reorganization
KW - UNITED States. Indian Health Service
KW - MEDICAL care -- United States
KW - HEALTH
KW - INDIGENOUS peoples of the Americas
N1 - Accession Number: 14637193; Source Information: 9/20/2004, Vol. 40 Issue 32, p21; Subject Term: EXECUTIVE department reorganization; Subject Term: UNITED States. Indian Health Service; Subject Term: MEDICAL care -- United States; Subject Term: HEALTH; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: ; Number of Pages: 1/2p; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Johnson, Victor J.
AU - Yucesoy, Berran
AU - Luster, Michael I.
T1 - Genotyping of single nucleotide polymorphisms in cytokine genes using real-time PCR allelic discrimination technology
JO - Cytokine
JF - Cytokine
Y1 - 2004/09/21/
VL - 27
IS - 6
M3 - Article
SP - 135
EP - 141
SN - 10434666
AB - Single nucleotide polymorphisms (SNPs), particularly those within regulatory regions of genes that code for cytokines often impact expression levels and can be disease modifiers. Investigating associations between cytokine genotype and disease outcome provides valuable insight into disease etiology and potential therapeutic intervention. Traditionally, genotyping for cytokine SNPs has been conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), a low throughput technique not amenable for use in large-scale cytokine SNP association studies. Recently, Taqman® real-time PCR chemistry has been adapted for use in allelic discrimination assays. The present study validated the accuracy and utility of real-time PCR technology for a number of commonly studied cytokine polymorphisms known to influence chronic inflammatory diseases. We show that this technique is amenable to high-throughput genotyping and overcomes many of the problematic features associated with PCR-RFLP including post-PCR manipulation, non-standardized assay conditions, manual allelic identification and false allelic identification due to incomplete enzyme digestion. The real-time PCR assays are highly accurate with an error rate in the present study of <1% and concordance rate with PCR-RFLP genotyping of 99.4%. The public databases of cytokine polymorphisms and validated genotyping assays highlighted in the present study will greatly benefit this important field of research. [Copyright &y& Elsevier]
AB - Copyright of Cytokine is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETICS
KW - NUCLEOTIDES
KW - POLYMORPHISM (Zoology)
KW - CYTOKINES
KW - Real-time PCR
KW - Single nucleotide polymorphism (SNP)
KW - Taqman
KW - Cytokine
KW - Polymorphism
N1 - Accession Number: 14037284; Johnson, Victor J.; Email Address: vjohnson3@cdc.gov Yucesoy, Berran 1 Luster, Michael I. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA; Source Info: Sep2004, Vol. 27 Issue 6, p135; Subject Term: GENETICS; Subject Term: NUCLEOTIDES; Subject Term: POLYMORPHISM (Zoology); Subject Term: CYTOKINES; Author-Supplied Keyword: Real-time PCR; Author-Supplied Keyword: Single nucleotide polymorphism (SNP); Author-Supplied Keyword: Taqman; Author-Supplied Keyword: Cytokine; Author-Supplied Keyword: Polymorphism; Language of Keywords: English; Language of Keywords: German; Language of Keywords: Chinese; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.cyto.2004.05.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, Nicholas F.
AU - Marshall, R.
T1 - Evaluation of an Electronic General-Practitioner-Based Syndromic Surveillance System -- Auckland, New Zealand, 2000-2001.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/09/25/9/24/2004 Supplement
VL - 53
M3 - Article
SP - 173
EP - 178
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Introduction: During 2000 and 2001, Auckland Regional Public Health Service piloted a general-practitioner--based syndromic surveillance system (GPSURV). Objectives: The pilot evaluated data capture, the method used to distinguish initial from follow-up visits, the definition of denominators, and the external validity of measured influenza-like illness trends. Methods: GPSURV monitored three acute infectious-disease syndromes: gastroenteritis, influenza-like illness, and skin and subcutaneous tissue infection. Standardized terms were used to describe the syndromes. Data were uploaded daily from clinics and transferred to a database via a secure network after one-way encryption of patient identifiers. Records were matched to allow the distinction of follow-ups from first visits, based on between-visit intervals of ≤ 8 weeks. Denominator populations were based on counts of unique patients treated at participating clinics during the previous 2 years. Record completion was examined by using before-and-after surveys of self-assessed standardized-term recording. Between-visit intervals were counted for matching records and alternative denominators were calculated on the basis of different observation periods. Weekly influenza-like illness rates were compared with rates generated by an alternative system. Results: Physicians' self-reported recording compliance was highest for skin and subcutaneous tissue infection (71%) and lowest for influenza-like illness (48%). Initial visits had 18%--19% greater compliance than follow-up visits. The number of physicians reporting increasing compliance during the pilot was greater than the number reporting decreases for all conditions. Comparison of data with an independent influenza-like illness surveillance system indicated a close agreement between the two data series. Conclusions: These results indicate that incidence of acute syndromes can be monitored, at least as successfully as a manual system, by using standardized... [ABSTRACT FROM AUTHOR]
AB - Copyright of MMWR: Morbidity & Mortality Weekly Report is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVALUATION
KW - PUBLIC health surveillance
KW - EPIDEMIOLOGY
KW - ELECTRONIC surveillance
KW - INFLUENZA
KW - AUCKLAND (N.Z.)
KW - NEW Zealand
N1 - Accession Number: 16346858; Jones, Nicholas F. 1; Email Address: nickj@adhb.govt.nz Marshall, R. 2; Affiliation: 1: Auckland Regional Public Health Service, Auckland, New Zealand 2: University of Auckland, Auckland, New Zealand; Source Info: 9/24/2004 Supplement, Vol. 53, p173; Subject Term: EVALUATION; Subject Term: PUBLIC health surveillance; Subject Term: EPIDEMIOLOGY; Subject Term: ELECTRONIC surveillance; Subject Term: INFLUENZA; Subject Term: AUCKLAND (N.Z.); Subject Term: NEW Zealand; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106585952
T1 - Expecting the unexpected -- drug safety, pharmacovigilance, and the prepared mind.
AU - Trontell A
Y1 - 2004/09/30/
N1 - Accession Number: 106585952. Language: English. Entry Date: 20050225. Revision Date: 20150711. Publication Type: Journal Article; commentary; tables/charts. Original Study: Bennett CL, Luminari S, Nissenson AR, Tallman MS, Klinge SA, McWilliams N, et al. Pure red-cell aplasia and epoetin therapy. (N ENGL J MED) 9/30/2004; 351 (14): 1403-1408. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Adverse Drug Event
KW - Erythropoietin -- Adverse Effects
KW - Pharmacovigilance
KW - Anemia -- Chemically Induced
KW - Data Collection
KW - United States Food and Drug Administration
SP - 1385
EP - 1387
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 351
IS - 14
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 15459298.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106591975
T1 - Putting prevention into practice. Screening for dementia.
AU - Randhawa G
Y1 - 2004/10//10/1/2004
N1 - Accession Number: 106591975. Language: English. Entry Date: 20050311. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Dementia -- Diagnosis -- In Old Age
KW - Mental Status -- Evaluation
KW - Aged
KW - Cognition -- Drug Effects
KW - Dementia -- Drug Therapy
KW - Education, Continuing (Credit)
KW - Male
KW - Medical Practice, Evidence-Based
SP - 1329
EP - 1402
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 70
IS - 7
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Program Director, U.S. Preventive Services Task Force, Center for Primary Care, Prevention and Clinical Partnerships Agency for Healthcare Research and Quality
U2 - PMID: 15508544.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106557145
T1 - Respiratory protection against bioaerosols: literature review and research needs.
AU - Rengasamy A
AU - Zhuang Z
AU - BerryAnn R
Y1 - 2004/10//2004 Oct
N1 - Accession Number: 106557145. Language: English. Entry Date: 20050107. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Aerosols
KW - Biological Warfare -- Prevention and Control
KW - Microbial Contamination
KW - Occupational Safety
KW - Respiratory Protective Devices -- Evaluation
KW - Respiratory Tract Infections -- Prevention and Control
KW - Terrorism -- Prevention and Control
KW - Air Microbiology
KW - Anthrax -- Prevention and Control
KW - Decontamination, Hazardous Materials
KW - Equipment Maintenance
KW - Filtration
KW - Literature Review
KW - Materials Testing
KW - Microbiology
KW - Risk Assessment
SP - 345
EP - 354
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 32
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - Research on respiratory protection against biologic agents is important to address major concerns such as occupational safety and terrorist attack. This review describes the literature on respiratory protection against bioaerosols and identifies research gaps. Respiratory protection is a complex field involving a number of factors, such as the efficiency of respirator filter material; face-piece fitting; and maintenance, storage, and reuse of respirators. Several studies used nonpathogenic microorganisms having physical characteristics similar to that of Mycobacterium tuberculosis to analyze microbial penetration through respirators. Some studies showed that high-efficiency particulate air (HEPA) and N95 filters provided a higher level of protection than dust/mist (DM) and dust/mist/fume (DMF) filters. Flow rate and relative humidity appear to alter the level of penetration of microorganisms through respirator filters. The relationship between microbial penetration through respirator filters and the aerodynamic diameter, length, or other physical characteristics of microorganisms remains controversial. Whether reaerosolization of bioaerosol particles should be a concern is unclear, given the fact that one study has demonstrated significant reaerosolization of 1- to 5-microm particles loaded onto respirator filters. Respirator maintenance, storage, and decontamination are important factors to be considered when reusing respirators. The respiratory protection against biologic warfare agents such as anthrax in military and civilian situations is described.
SN - 0196-6553
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Bruceton, PA 15236; rda5@cdc.gov
U2 - PMID: 15454893.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fraunfelder, Frederick W.
T1 - Ocular side effects from herbal medicines and nutritional supplements
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
Y1 - 2004/10//
VL - 138
IS - 4
M3 - Article
SP - 639
EP - 647
SN - 00029394
AB - To review the more significant herbal and nutritional agents of clinical importance to ophthalmologists and describe the ocular side effects for each. World Health Organization (WHO) classification and guidelines for clinicians are provided.Retrospective observational case series.A retrospective observational case series of reports of ocular side effects or systemic side effects from medications used for the eye from herbal medicines and nutritional supplements. Cases were collected from spontaneous reports submitted to the WHO, the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects. A review of the world''s literature was performed to obtain additional case reports and insight into adverse ocular reactions. Data were collected on age, gender, duration of therapy, concomitant medications, dosage, and dechallenge and rechallenge results.The National Registry of Drug-Induced Ocular Side Effects received 263 spontaneous reports, in addition to 60 case reports from the literature. Canthaxanthine, chamomile, Datura, Echinacea purpurea, Ginkgo biloba, licorice, niacin, and vitamin A are all associated with clinically significant ocular side effects.Herbal medicines and nutritional supplements can cause ocular side effects. Clinicians need to recognize these adverse events, because a large segment of the population uses them, many times without the treating physician''s knowledge. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Ophthalmology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBAL medicine
KW - GINKGO
KW - RETINOIDS
KW - EYE
N1 - Accession Number: 14729646; Fraunfelder, Frederick W. 1; Email Address: eyedrug@ohsu.edu; Affiliation: 1: Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA; Collaborating Center for International Drug Monitoring, World Health Organization (WHO), Uppsala, Sweden; the Food and Drug Administration, Rockville, Maryland; and the National Registry of Drug-Induced Ocular Side Effects, Casey Eye Institute, Portland, Oregon, USA; Source Info: Oct2004, Vol. 138 Issue 4, p639; Subject Term: HERBAL medicine; Subject Term: GINKGO; Subject Term: RETINOIDS; Subject Term: EYE; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ajo.2004.04.072
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - D'Agnillo, Felice
T1 - Redox active hemoglobin enhances lipopolysaccharide-induced injury to cultured bovine endothelial cells.
JO - American Journal of Physiology: Heart & Circulatory Physiology
JF - American Journal of Physiology: Heart & Circulatory Physiology
Y1 - 2004/10//
VL - 56
IS - 4
M3 - Article
SP - H1875
EP - H1882
SN - 03636135
AB - The interaction of cell-free hemoglobin with lipopolysaccharide (LPS) is thought to aggravate the pathophysiology of sepsis and/or septic shock. This study examines the possible modulatory role of cell-free hemoglobin on LPS-induced apoptosis of cultured bovine aortic endothelial cells. Experiments were performed with or without fetal bovine serum, a source of LPS-binding protein and soluble CD14. In the absence of serum, LPS alone or coincubated with purified bovine hemoglobin (BvHb), human hemoglobin (Hb), or α-cross-linked Hb (ααHb) did not induce apoptosis. In the presence of serum, LPS induced significant apoptosis. LPS combined with BvHb, Hb, or ααHb produced the same extent of apoptosis as LPS alone. To examine whether the H2O2-driven redox activity of hemoglobin alters LPS-induced apoptosis, glucose oxidase was added to the system to generate a subtoxic flux of H2O2. The combined treatment of LPS, glucose oxidase, and BvHb, Hb, or ααHb enhanced apoptosis compared with LPS alone. These findings support a possible mechanism whereby the redox cycling of hemoglobin, and not its direct interaction with LPS, contributes to the hemoglobin-mediated enhancement of LPS-related pathophysiology. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Heart & Circulatory Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATION-reduction reaction
KW - HEMOGLOBIN
KW - ENDOTHELIUM
KW - ENDOTOXINS
KW - APOPTOSIS
KW - HYDROGEN peroxide
KW - apoptosis
KW - ferryl hemoglobin
KW - glucose oxidase
KW - hydrogen peroxide
N1 - Accession Number: 14723416; D'Agnillo, Felice 1; Email Address: dagnillo@cber.fda.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Oct2004, Vol. 56 Issue 4, pH1875; Subject Term: OXIDATION-reduction reaction; Subject Term: HEMOGLOBIN; Subject Term: ENDOTHELIUM; Subject Term: ENDOTOXINS; Subject Term: APOPTOSIS; Subject Term: HYDROGEN peroxide; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: ferryl hemoglobin; Author-Supplied Keyword: glucose oxidase; Author-Supplied Keyword: hydrogen peroxide; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 3 Color Photographs, 3 Black and White Photographs, 13 Graphs; Document Type: Article
L3 - 10.1152/ajpheart.00164.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hefflin, Brockton J.
AU - Gross, Thomas P.
AU - Schroeder, Thomas J.
T1 - Estimates of medical device–associated adverse events from emergency departments
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2004/10//
VL - 27
IS - 3
M3 - Article
SP - 246
EP - 253
SN - 07493797
AB - Background: The true public health burden of adverse events associated with medical devices is unknown. The purpose of this study, therefore, was to produce the first-ever national estimates of medical device–associated adverse events resulting in emergency department (ED) visits.Methods: From July 1999 through June 2000, reports of 10,395 medical device–associated adverse events were accumulated using the National Electronic Injury Surveillance System (NEISS), which collects information on product-related injuries from the ED records of a national stratified probability sample of hospitals. The reports were used to estimate annual total number of medical device–associated adverse events as well as number of adverse events associated with specific devices, injury diagnoses, demographic characteristics, and patient disposition status.Results: The total estimated number of adverse events was 454,383 (95% confidence interval [CI]=371,156–537,610), involving a broad range of devices from 15 medical specialty groups. Unintentional traumatic events associated with a particular device appeared to be the most common mechanism of injury. The most prevalent types of injuries included contusions/abrasions, punctures, and lacerations; 13% of total estimated cases resulted in patient hospitalization. Adverse events occurred within healthcare facilities, and some were occupationally related, although they occurred at home more frequently than any other location (about 42%).Conclusions: The magnitude of the total estimate, which is over four times greater than the annual number of adverse event reports received by medical device–regulating surveillance systems, emphasizes medical device–associated adverse events as an under-recognized public health problem. Planned collection of more detailed NEISS data will allow for appropriate public health interventions. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - MEDICAL equipment
KW - EMERGENCY medical services
KW - MEDICAL care
N1 - Accession Number: 14513869; Hefflin, Brockton J. 1; Email Address: bjh@cdrh.fda.gov Gross, Thomas P. 1 Schroeder, Thomas J. 2; Affiliation: 1: U.S. Food and Drug Administration Center for Devices and Radiological Health (Hefflin, Gross), Rockville, Maryland, USA 2: U.S. Consumer Product Safety Commission (Schroeder), Bethesda, Maryland, USA; Source Info: Oct2004, Vol. 27 Issue 3, p246; Subject Term: PUBLIC health; Subject Term: MEDICAL equipment; Subject Term: EMERGENCY medical services; Subject Term: MEDICAL care; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.amepre.2004.04.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Richardson, David B.
AU - Loomis, Dana
AU - Bena, James
AU - Bailer, A. John
T1 - Fatal Occupational Injury Rates in Southern and Non-Southern States, by Race and Hispanic Ethnicity.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/10//
VL - 94
IS - 10
M3 - Article
SP - 1756
EP - 1761
PB - American Public Health Association
SN - 00900036
AB - Objectives. We investigated fatal occupational injury rates in the United States by race and Hispanic ethnicity during the period 1990-1996. Methods. Fatalities were identified by means of the national traumatic occupational fatalities surveillance system. Fatal occupational injury rates were calculated by race/ethnicity and region using US-census-based workforce estimates. Results. Non-Hispanic Black men in the South had the highest fatal occupational injury rate (8.5 per 100000 worker-years), followed by Hispanic men in the South (7.9 per 100000 worker-years). Fatal injury rates for Hispanic men increased over the study period, exceeding rates for non-Hispanic Black men in the latter years of observation. Conclusions. These data suggest a change in the demographics of fatal occupational injuries in the United States. Hispanic men in the South appear to be emerging as the group with the nation's highest unintentional fatal occupational injury rate. (Am J Public Health. 2004;94:1756-1761). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - RACE
KW - ETHNICITY
KW - HISPANIC Americans
KW - UNITED States
N1 - Accession Number: 14653874; Richardson, David B. 1; Email Address: david_richardson@unc.edu Loomis, Dana 1 Bena, James 2 Bailer, A. John 2,3; Affiliation: 1: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 2: Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Department of Mathematics and Statistics, Miami University, Oxford, Ohio; Source Info: Oct2004, Vol. 94 Issue 10, p1756; Subject Term: WORK-related injuries; Subject Term: RACE; Subject Term: ETHNICITY; Subject Term: HISPANIC Americans; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 4865
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Hettick, Justin M.
AU - Kashon, Michael L.
AU - Simpson, Janet P.
AU - Siegel, Paul D.
AU - Mazurek, Gerald H.
AU - Weissman, David N.
T1 - Proteomic profiling of Intact Mycobacteria by Matrix-Assisted Laser Desorption/lonization Time-of-Flight Mass spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2004/10//10/1/2004
VL - 76
IS - 19
M3 - Abstract
SP - 5769
EP - 5776
SN - 00032700
AB - Current methods for the identification of mycobacteria in culture are time-consuming, requiring as long as 12 weeks for positive identification. One potential approach to rapid mycobacterial identification is to utilize proteomic profiling of cultures by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF MS). In this report, we have applied MALDI-TOF MS to proteomic profiling of cultured microorganisms representing six species of the genus Mycobacterium. We find that analysis of acetonitrile/trifluoroacetic acid cellular extracts produces data similar to that of the analysis of deposited whole cells, while minimizing human contact with the microorganisms and rendering them nonviable. A matrix composition of α-cyano-4-hydroxycinnamic acid with fructose yields highly reproducible MALDI-TOF spectra. Statistical analysis of MALDI-TOF MS data allows differentiation of each individual mycobacterial species on the basis of unique mass fingerprints. The methodology allows identification of a number of unique (potentially diagnostic) biomarkers as targets for protein identification by MS/MS experiments. In addition, we observe a number of signals common to all mycobacterial species studied by MALDI-TOF MS, which may be genus-specific bio- markers. The potentially genus-specific biomarkers occur at low mass (<2 kDa) and are likely to be lipids and cell wail components such as mycolic acids. This study demonstrates the potential for mass spectrometry-based idendfication/classthcatiohl of mycobacteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM
KW - PROTEOMICS
KW - MATRIX-assisted laser desorption-ionization
KW - TIME-of-flight mass spectrometry
KW - TIME measurements
KW - SPECTRUM analysis
N1 - Accession Number: 14695733; Hettick, Justin M. 1; Email Address: ayf2@cdc.gov Kashon, Michael L. 1 Simpson, Janet P. 1 Siegel, Paul D. 1 Mazurek, Gerald H. 2 Weissman, David N. 1; Affiliation: 1: National Institute for Occupational Safety and Health. 2: National Center for HIV, STD and TB Prevention.; Source Info: 10/1/2004, Vol. 76 Issue 19, p5769; Subject Term: MYCOBACTERIUM; Subject Term: PROTEOMICS; Subject Term: MATRIX-assisted laser desorption-ionization; Subject Term: TIME-of-flight mass spectrometry; Subject Term: TIME measurements; Subject Term: SPECTRUM analysis; Number of Pages: 8p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Elisa T.
AU - Begum, Momotaz
AU - Wang, Wenyu
AU - Blackett, Piers R.
AU - Blevins, Kathleen S.
AU - Stoddart, Martha
AU - Tolbert, Bernadine
AU - Alaupovic, Petar
T1 - Type 2 diabetes and impaired fasting glucose in American Indians aged 5–40 years: the Cherokee diabetes study
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2004/10//
VL - 14
IS - 9
M3 - Article
SP - 696
EP - 704
SN - 10472797
AB - Purpose: To estimate the prevalence of type 2 diabetes and impaired fasting glucose (IFG) and to study several potential risk factors for type 2 diabetes among Oklahoma Cherokees aged 5 to 40 years.Methods: A random sample of 2205 members of the Cherokee Nation of Oklahoma aged 5 to 40 years was recruited. Demographic, clinical, and laboratory data were collected. Type 2 diabetes and IFG were determined using the 1997 American Diabetes Association (ADA) criteria. Relationships between type 2 diabetes and potential risk factors were examined by univariate and multivariate regression methods.Results: According to ADA criteria, the age-adjusted prevalence proportions of type 2 diabetes were 4.3% in females and 4.8% in males. Among the 89 individuals who had type 2 diabetes, 31 were newly diagnosed. Thirty-two (1.5%, 18 females and 14 males) were found to have IFG. The prevalence of type 2 diabetes and IFG increased with age, number of parents with diabetes, obesity, degree of Indian heritage, high triglyceride value, and low HDL cholesterol.Conclusions: The increasing prevalence of type 2 diabetes in young American Indians is alarming. The findings must be disseminated to the Indian communities and their health care providers. Preventive measures and early detection programs must be designed and implemented for children and adolescents in this population. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-insulin-dependent diabetes
KW - CARBOHYDRATE intolerance
KW - DIABETES
KW - DISEASES -- Risk factors
KW - NATIVE Americans
KW - American Indians
KW - Children and Young Adults
KW - Risk Factors
KW - Type 2 Diabetes
N1 - Accession Number: 14428978; Lee, Elisa T.; Email Address: elisa-lee@ouhsc.edu Begum, Momotaz 1 Wang, Wenyu 1 Blackett, Piers R. 1 Blevins, Kathleen S. 1 Stoddart, Martha 1 Tolbert, Bernadine 1 Alaupovic, Petar 1; Affiliation: 1: From the Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK (E.T.L., M.B., W.W., K.S.B., M.S.); Department of Pediatrics, OUHSC, Oklahoma City, OK (P.R.B.); Oklahoma City Area Indian Health Service, Oklahoma City, OK (B.T.); and Oklahoma Medical Research Foundation, Oklahoma City, OK (P.A.) USA; Source Info: Oct2004, Vol. 14 Issue 9, p696; Subject Term: NON-insulin-dependent diabetes; Subject Term: CARBOHYDRATE intolerance; Subject Term: DIABETES; Subject Term: DISEASES -- Risk factors; Subject Term: NATIVE Americans; Author-Supplied Keyword: American Indians; Author-Supplied Keyword: Children and Young Adults; Author-Supplied Keyword: Risk Factors; Author-Supplied Keyword: Type 2 Diabetes; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.annepidem.2003.10.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SCHULTE, P. A.
AU - LENTZ, T. J.
AU - ANDERSON, V. P.
AU - LAMBORG, A. D.
T1 - Knowledge Management in Occupational Hygiene: The United States Example.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2004/10//
VL - 48
IS - 7
M3 - Article
SP - 583
EP - 594
SN - 00034878
AB - Knowledge management is an emerging field focusing on assessing the creation, transfer, and utilization of knowledge to address specific challenges. Generally, knowledge management has described efforts within and between companies to consider knowledge as a manageable asset. In this paper, we suggest that occupational hygiene knowledge can be considered a manageable asset by businesses and that the entire field of occupational hygiene in the USA can be appraised in terms of knowledge management. The knowledge cycle creates a foundation for knowledge management. Knowledge creation (research, recognition and evaluation), transfer (distribution, dissemination and diffusion), and utilization (risk management and control) make up the key elements of the knowledge cycle. Defining and understanding the roles of knowledge cycle elements facilitate the application of knowledge management to problems, systems, and situations in individual companies and in the field of occupational hygiene in general. Examples of current, effective knowledge management practices within occupational hygiene in the USA are described, and recommendations for further utilization of knowledge management principles are also presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Knowledge management
KW - Industrial hygiene -- United States
KW - Knowledge transfer (Communication)
KW - Risk management in business
KW - Management
KW - United States
KW - dissemination
KW - knowledge
KW - management
KW - occupational hygiene
KW - transfer
KW - utilization
N1 - Accession Number: 20367906; SCHULTE, P. A. 1; Email Address: pas4@CDC.gov; LENTZ, T. J. 1; ANDERSON, V. P. 1; LAMBORG, A. D. 1; Affiliations: 1: National Institute for Occupational Safety and Health: Centers for Disease Control and Prevention, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: Oct2004, Vol. 48 Issue 7, p583; Subject Term: Knowledge management; Subject Term: Industrial hygiene -- United States; Subject Term: Knowledge transfer (Communication); Subject Term: Risk management in business; Subject Term: Management; Subject: United States; Author-Supplied Keyword: dissemination; Author-Supplied Keyword: knowledge; Author-Supplied Keyword: management; Author-Supplied Keyword: occupational hygiene; Author-Supplied Keyword: transfer; Author-Supplied Keyword: utilization; Number of Pages: 12p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1093/annhyg/meh061
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hayes, Joshua R.
AU - English, Linda L.
AU - Cart, Lewis E.
AU - Wagner, David D.
AU - Joseph, Sam W.
T1 - Multiple-Antibiotic Resistance of Enterococcus spp. Isolated from Commercial Poultry Production Environments.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/10//
VL - 70
IS - 10
M3 - Article
SP - 6005
EP - 6011
SN - 00992240
AB - The potential impact of food animals in the production environment on the bacterial population as a result of antimicrobial drug use for growth enhancement continues to be a cause for concern. Enterococci from 82 farms within a poultry production region on the eastern seaboard were isolated to establish a baseline of susceptibility profiles for a number of antimicrobials used in production as well as clinical environments. Of the 541 isolates recovered, Enterococcus faecalis (53%) and E. faecium (31%) were the predominant species, while multiresistant antimicrobial phenotypes were observed among all species. The prevalence of resistance among isolates of E. faecalis was comparatively higher among lincosamide, macrolide, and tetracycline anti-microbials, while isolates of E. faecium were observed to be more frequently resistant to fluoroquinolones and penicillins. Notably, 63% of the E. faecium isolates were resistant to the streptogramin quinupristin-dalfopristin, while high-level gentamicin resistance was observed only among the E. faecalis population, of which 7% of the isolates were resistant. The primary observations are that enterococci can be frequently isolated from the poultry production environment and can be multiresistant to antimicrobials used in human medicine. The high frequency with which resistant enterococci are isolated from this environment suggests that these organisms might be useful as sentinels to monitor the development of resistance resulting from the usage of antimicrobial agents in animal production. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIAL sensitivity tests
KW - ENTEROCOCCUS
KW - POULTRY products
KW - MICROBIOLOGY -- Technique
KW - ANIMAL culture
KW - MOLECULAR genetics
KW - MICROBIOLOGY
N1 - Accession Number: 14777192; Hayes, Joshua R. 1,2 English, Linda L. 2 Cart, Lewis E. 3 Wagner, David D. 2 Joseph, Sam W. 1; Email Address: sj13@umail.umd.edu; Affiliation: 1: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park 2: Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 3: Department of Biological Resources Engineering, University of Maryland, College Park; Source Info: Oct2004, Vol. 70 Issue 10, p6005; Subject Term: MICROBIAL sensitivity tests; Subject Term: ENTEROCOCCUS; Subject Term: POULTRY products; Subject Term: MICROBIOLOGY -- Technique; Subject Term: ANIMAL culture; Subject Term: MOLECULAR genetics; Subject Term: MICROBIOLOGY; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112390 Other Poultry Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1128/AEM.70.10.6005-6011.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lowe, G. L.
AU - Salmon, R. L.
AU - Thomas, D. Rh
AU - Evans, M. R.
T1 - Declining incidence of chickenpox in the absence of universal childhood immunisation.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2004/10//
VL - 89
IS - 10
M3 - Article
SP - 966
EP - 969
SN - 00039888
AB - Objective: To examine the epidemiology of chickenpox in Wales from 1986 to 2001. Design: Descriptive analysis of chickenpox consultations reported by the Welsh general practice sentinel surveillance scheme for infectious diseases, compared with annual shingles consultation rates from the same scheme to exclude reporting fatigue and data from a general practice morbidity database to validate results. Selling: A total of 226 884 patients registered with one of 30 volunteer general practices participating in the sentinel surveillance scheme. Main outcome measures: Age standardised and age specific incidence of chickenpox. Results: Crude and age standardised consultation rates for chickenpox declined from 1986 to 2001, with loss of epidemic cycling. Rates remained stable in 0-4 year olds but declined in all older age groups, particularly those aged 5-14 years. Shingles consultation rates remained constant over the same period. Data from the morbidity database displayed similar trends. Conclusion: General practitioner consultation rates for chickenpox are declining in Wales except in pre-school children. These findings are unlikely to be a reporting artefact but may be explained either by an overall decline in transmission or increased social mixing in those under 5 years old, through formal child care and earlier school entry, and associated increasing rates of mild or subclinical infection in this age group. Further investigation, particularly by serological surveillance, is necessary before universal varicella immunisation can be considered in the UK. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHICKENPOX
KW - HERPESVIRUS diseases
KW - COMMUNICABLE diseases -- Transmission
KW - IMMUNIZATION
KW - EPIDEMIOLOGY
KW - MEDICAL consultation
N1 - Accession Number: 14813109; Lowe, G. L. 1; Email Address: lowe@nphs.wales.nhs.uk Salmon, R. L. 1 Thomas, D. Rh 1 Evans, M. R. 1; Affiliation: 1: National Public Health Service Communicable Disease Surveillance Centre, Abton House, Cardiff CF14 3QX, UK.; Source Info: Oct2004, Vol. 89 Issue 10, p966; Subject Term: CHICKENPOX; Subject Term: HERPESVIRUS diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: IMMUNIZATION; Subject Term: EPIDEMIOLOGY; Subject Term: MEDICAL consultation; Number of Pages: 4p; Document Type: Article
L3 - 10.1136/adc.2002.021618
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106607696
T1 - Declining incidence of chickenpox in the absence of universal childhood immunisation.
AU - Lowe GL
AU - Salmon RL
AU - Thomas DR
AU - Evans MR
Y1 - 2004/10//
N1 - Accession Number: 106607696. Language: English. Entry Date: 20050415. Revision Date: 20150711. Publication Type: Journal Article; cartoon; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0372434.
KW - Chickenpox Vaccine -- Therapeutic Use -- In Infancy and Childhood
KW - Chickenpox -- Epidemiology -- Wales
KW - Immunization Programs
KW - Adolescence
KW - Age Factors
KW - Child
KW - Child, Preschool
KW - Descriptive Research
KW - Disease Surveillance
KW - Female
KW - Herpes Zoster -- Epidemiology -- Wales
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Kendall's Tau
KW - Male
KW - Wales
KW - Human
SP - 966
EP - 969
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
JA - ARCH DIS CHILD
VL - 89
IS - 10
PB - BMJ Publishing Group
AB - OBJECTIVE: To examine the epidemiology of chickenpox in Wales from 1986 to 2001. DESIGN: Descriptive analysis of chickenpox consultations reported by the Welsh general practice sentinel surveillance scheme for infectious diseases, compared with annual shingles consultation rates from the same scheme to exclude reporting fatigue and data from a general practice morbidity database to validate results. SETTING: A total of 226,884 patients registered with one of 30 volunteer general practices participating in the sentinel surveillance scheme. MAIN OUTCOME MEASURES: Age standardised and age specific incidence of chickenpox. RESULTS: Crude and age standardised consultation rates for chickenpox declined from 1986 to 2001, with loss of epidemic cycling. Rates remained stable in 0-4 year olds but declined in all older age groups, particularly those aged 5-14 years. Shingles consultation rates remained constant over the same period. Data from the morbidity database displayed similar trends. CONCLUSION: General practitioner consultation rates for chickenpox are declining in Wales except in pre-school children. These findings are unlikely to be a reporting artefact but may be explained either by an overall decline in transmission or increased social mixing in those under 5 years old, through formal child care and earlier school entry, and associated increasing rates of mild or subclinical infection in this age group. Further investigation, particularly by serological surveillance, is necessary before universal varicella immunisation can be considered in the UK.
SN - 0003-9888
AD - National Public Health Service Communicable Disease Surveillance Centre, Abton House, Cardiff CF14 3QX, UK; Gwen.lowe@nphs.wales.nhs.uk
U2 - PMID: 15383443.
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DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Lazarus, E.
T1 - Implementation of the FDA regulatory approach to cells and tissue: Focus on cord blood
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2004/10//
VL - 10
IS - 10
M3 - Abstract
SP - 739
EP - 739
SN - 10838791
N1 - Accession Number: 14511244; Lazarus, E. 1; Affiliation: 1: Division of Human Tissues, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, FDA; Source Info: Oct2004, Vol. 10 Issue 10, p739; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.bbmt.2004.06.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slavin-Chiorini, Dale C
AU - Catalfamo, Marta
AU - Kudo-Saito, Chie
AU - Hodge, James W
AU - Schlom, Jeffrey
AU - Sabzevari, Helen
T1 - Amplification of the lytic potential of effector/memory CD8+ cells by vector-based enhancement of ICAM-1 (CD54) in target cells: implications for intratumoral vaccine therapy.
JO - Cancer Gene Therapy
JF - Cancer Gene Therapy
Y1 - 2004/10//
VL - 11
IS - 10
M3 - Article
SP - 665
EP - 680
PB - Nature Publishing Group
SN - 09291903
AB - We demonstrated that enhanced expression of the costimulatory molecules CD80, CD54 and CD48 (designated rF-TRICOM) on target cells, as delivered via a recombinant fowlpox vector, results in an increased state of stimulation of CD8+ T cells, and consequent increased lysis of target cells. CTL studies in conjunction with antibody-blocking studies demonstrated that the enhanced effector activity of these CD8+ T cells is mediated mainly through CD54. Intracellular staining of CD8+ cells that interact with target cells infected with rF-TRICOM showed that they contain higher amounts of perforin and have a higher level of perforin message. Enhanced expression of costimulatory molecules (specifically CD54) on target cells using rF-TRICOM vectors also leads to the formation of stable conjugates/synapses between targets and T cells. The interaction of T cells with target cells that overexpress costimulatory molecules upon infection with rF-TRICOM leads to enhanced signaling through Lck, ZAP70, and STAT-1 in CD8+ T cells and heightened lytic activity of CD8+ cells through the formation of a greater number of immunological synapses. This, in turn, leads to enhanced signaling in T cells. Finally, studies were conducted in mice in which CEA is a self-antigen in an attempt to understand the potential clinical relevancy of intratumoral vaccine therapy. Mice were transplanted subcutaneously with CEA expressing tumors. Intratumoral (i.t.) vaccination was administered 8 days post tumor transplant. Mice vaccinated i.t. with rF-TRICOM demonstrated significantly reduced tumor growth and 40%of the mice had complete tumor regression. The antitumor effects were further improved by the addition of tumor antigen (CEA) in the vaccination by utilizing rF-CEA/TRICOM, with 80%of the mice experiencing complete tumor regression. These studies thus support the concept of intratumoral vaccination employing vectors expressing costimulatory... [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Gene Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOWL pox
KW - T cells
KW - IMMUNOGLOBULINS
KW - SYNAPSES
KW - CANCER vaccines
KW - MICE as laboratory animals
KW - VACCINATION
KW - costimulation
KW - CTL
KW - T lymphocytes
KW - tumor immunity
KW - vaccination
N1 - Accession Number: 14541872; Slavin-Chiorini, Dale C 1,2 Catalfamo, Marta 3 Kudo-Saito, Chie 1 Hodge, James W 1 Schlom, Jeffrey 1; Email Address: js141c@nih.gov Sabzevari, Helen 1; Affiliation: 1: Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 2: Cellular, Gene Therapy and Monoclonal Products Branch, Division of Application Review and Policy, Center for Biologics Evaluation and Review, Food and Drug Administration, Rockville, MD, USA 3: Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Source Info: Oct2004, Vol. 11 Issue 10, p665; Subject Term: FOWL pox; Subject Term: T cells; Subject Term: IMMUNOGLOBULINS; Subject Term: SYNAPSES; Subject Term: CANCER vaccines; Subject Term: MICE as laboratory animals; Subject Term: VACCINATION; Author-Supplied Keyword: costimulation; Author-Supplied Keyword: CTL; Author-Supplied Keyword: T lymphocytes; Author-Supplied Keyword: tumor immunity; Author-Supplied Keyword: vaccination; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 16p; Document Type: Article
L3 - 10.1038/sj.cgt.7700741
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Rosa, Maria I.
T1 - EQUIPMENT FIRES CAUSE INJURIES.
JO - Coal Age
JF - Coal Age
Y1 - 2004/10//
VL - 109
IS - 10
M3 - Article
SP - 28
EP - 31
PB - Mining Media Inc.
SN - 10407820
AB - Presents information on the results of a study conducted by the U.S. National Institute for Occupational Safety and Health on the trends in equipment fires at several coal mines in the U.S. from 1990 to 1999. Number of equipment fires in underground coal mines; Types of equipment that were involved in surface fires at underground coal mines; Causes of equipment fires at surface mines.
KW - COAL mines & mining
KW - INDUSTRIAL equipment
KW - MINE fires
KW - EQUIPMENT & supplies
KW - MINE accidents
KW - FIRES
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 15017693; De Rosa, Maria I. 1; Affiliations: 1: Industrial hygienist, Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pa; Issue Info: Oct2004, Vol. 109 Issue 10, p28; Thesaurus Term: COAL mines & mining; Thesaurus Term: INDUSTRIAL equipment; Subject Term: MINE fires; Subject Term: EQUIPMENT & supplies; Subject Term: MINE accidents; Subject Term: FIRES; Subject: UNITED States ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Chart, 2 Graphs; Document Type: Article; Full Text Word Count: 3163
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hiroshi Yamada
T1 - Suppressive oligodeoxynucleotides inhibit CpG-induced inflammation of the mouse lung.
JO - Critical Care Medicine
JF - Critical Care Medicine
Y1 - 2004/10//
VL - 32
IS - 10
M3 - Article
SP - 2045
EP - 2049
SN - 00903493
AB - OBJECTIVE:: To examine the effect of suppressive oligodeoxynucleotides (ODNs) on the pulmonary inflammation induced by immunostimulatory CpG DNA.DESIGN:: Prospective, randomized, controlled study.SETTING:: Research laboratories.SUBJECTS:: RAW 264.7 murine macrophage-like cell line and BALB/c mice.INTERVENTIONS:: RAW 264.7 cells were incubated with bacterial DNA or CpG ODN, alone or combined with suppressive ODN. The in vivo effect of suppressive ODN was determined using an acute lung injury model. CpG ODN alone or combined with suppressive ODN was instilled into the mouse lung.MEASUREMENTS AND MAIN RESULTS:: Production of tumor necrosis factor (TNF)-? and macrophage inflammatory protein (MIP)-2 by RAW 264.7 cells were measured by enzyme-linked immunosorbent assay (ELISA), whereas their messenger RNA levels were determined by reverse transcriptase-polymerase chain reaction. Synthetic ODN containing CpG motifs (CpG ODN) mimicked the ability of bacterial DNA to stimulate the production of TNF-? and MIP-2. Suppressive ODN significantly inhibited the activation of RAW 264.7 cells by both bacterial DNA and CpG ODN. In the lung injury model, production of proinflammatory cytokines (TNF-? and IL-6) and chemokines (MIP-2 and KC) in bronchoalveolar lavage (BAL) fluids was measured by ELISA. Neutrophil accumulation in the alveolar spaces was also evaluated. Instillation of CpG ODN into the lungs of normal mice triggered the synthesis of TNF-?, IL-6, MIP-2, and KC. Suppressive ODN significantly blocked the production of these proinflammatory cytokines and chemokines and also reduced neutrophil mobilization into the alveolar spaces by CpG DNA.CONCLUSIONS:: Proinflammatory cytokines and chemokines are up-regulated by CpG motifs in bacterial DNA. Suppressive ODN significantly inhibits the inflammatory response induced by CpG DNA in murine macrophages and the lung. This study supports the use of suppressive ODN to reduce the deleterious inflammatory responses induced by bacterial DNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDES
KW - RESEARCH
KW - INFLAMMATION -- Treatment
KW - CARDIOPULMONARY system -- Diseases
KW - LUNG diseases -- Diagnosis
KW - RESPIRATORY organs
N1 - Accession Number: 20365495; Hiroshi Yamada 1; Affiliation: 1: From the Department of Anesthesiology (HY), Yokohama City University, School of Medicine; Akira Innate Immunity Project (KJI), ERATO, Japan Science and Technology Agency, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University; and the Section of Retroviral Immunology (DMM), Center for Biologics Evaluation and Research, U.S. Food and Drug Administration.; Source Info: Oct2004, Vol. 32 Issue 10, p2045; Subject Term: NUCLEOTIDES; Subject Term: RESEARCH; Subject Term: INFLAMMATION -- Treatment; Subject Term: CARDIOPULMONARY system -- Diseases; Subject Term: LUNG diseases -- Diagnosis; Subject Term: RESPIRATORY organs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsai, Chen-An
AU - Chen, Chun-Houh
AU - Lee, Te-Chang
AU - Ho, I-Ching
AU - Yang, Ueng-Cheng
AU - Chen, James J.
T1 - Gene Selection for Sample Classifications in Microarray Experiments.
JO - DNA & Cell Biology
JF - DNA & Cell Biology
Y1 - 2004/10//
VL - 23
IS - 10
M3 - Article
SP - 607
EP - 614
PB - Mary Ann Liebert, Inc.
SN - 10445498
AB - DNA microarray technology provides useful tools for profiling global gene expression patterns in different cell/tissue samples. One major challenge is the large number of genes relative to the number of samples. The use of all genes can suppress or reduce the performance of a classification rule due to the noise of nondiscriminatory genes. Selection of an optimal subset from the original gene set becomes an important prestep in sample classification. In this study, we propose a family-wise error (FWE) rate approach to selection of discriminatory genes for two-sample or multiple-sample classification. The FWE approach controls the probability of the number of one or more false positives at a prespecified level. A public colon cancer data set is used to evaluate the performance of the proposed approach for the two classification methods: k nearest neighbors (k-NN) and support vector machine (SVM). The selected gene sets from the proposed procedure appears to perform better than or comparable to several results reported in the literature using the univariate analysis without performing multivariate search. In addition, we apply the FWE approach to a toxicogenomic data set with nine treatments (a control and eight metals, As, Cd, Ni, Cr, Sb, Pb, Cu, and AsV) for a total of 55 samples for a multisample classification. Two gene sets are considered: the gene set ΩF formed by the ANOVA F-test, and a gene set ΩT formed by the union of one-versus-all t-tests. The predicted accuracies are evaluated using the internal and external crossvalidation. Using the SVM classification, the overall accuracies to predict 55 samples into one of the nine treatments are above 80% for internal crossvalidation. ΩF has slightly higher accuracy rates than ΩT. The overall predicted accuracies are above 70% for the external crossvali- dation; the two gene sets ΩT and ΩF performed equally well. [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA & Cell Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - GENETIC regulation
KW - DNA microarrays
KW - IMMOBILIZED nucleic acids
KW - GENES
KW - NUCLEIC acids
KW - HEREDITY
N1 - Accession Number: 15109752; Tsai, Chen-An 1 Chen, Chun-Houh 2 Lee, Te-Chang 3,4 Ho, I-Ching 4 Yang, Ueng-Cheng 5 Chen, James J. 1; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 2: Institute of Statistical Science, Academia Sinica, Taipei, 115, Taiwan 3: Institute of Biochemistry Sciences, Academia Sinica, Taipei, 115, Taiwan 4: Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, 112, Taiwan 5: Institute of Biochemistry, National Yang-Ming University, Taipei, 112, Taiwan; Source Info: Oct2004, Vol. 23 Issue 10, p607; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: DNA microarrays; Subject Term: IMMOBILIZED nucleic acids; Subject Term: GENES; Subject Term: NUCLEIC acids; Subject Term: HEREDITY; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3 - 10.1089/1044549042476947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15109752&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delongchamp, Robert R.
AU - Velasco, Cruz
AU - Razzaghi, Mehdi
AU - Harris, Angela
AU - Casciano, Dan
T1 - Median-of-Subsets Normalization of Intensities for cDNA Array Data.
JO - DNA & Cell Biology
JF - DNA & Cell Biology
Y1 - 2004/10//
VL - 23
IS - 10
M3 - Article
SP - 653
EP - 659
PB - Mary Ann Liebert, Inc.
SN - 10445498
AB - cDNA arrays allow quantitative measurement of expression levels for thousands of genes simultaneously. The measurements are affected by many sources of variation, and substantial improvements in the precision of estimated effects accompany adjustments for these effects. Two generic nuisance variations, one associated with the magnitude of expression and the other associated with array location, are common in data from filter arrays. Procedures, like normalization using lowess regression, are effective at reducing variation associated with magnitude, and they have been widely adopted. However, variation associated with location has received less attention. Here, a simple, but effective method based on localized median is expounded for dealing with these nuisance effects, and its properties are discussed. The proposed methodology handles location-dependent variation ("splotches") and magnitude-dependent variation (background and/or saturation) effectively. The procedure is related to lowess when implemented to adjust magnitude-dependent variation, and it performs similarly. The proposed methodology is illustrated with data from the National Center for Toxicological Research (NCTR), where treatment differences in levels of mRNA from rat hepatocytes were assessed using 33 P-labeled samples hybridized to cDNA spotted arrays. Normalizing intensities by the median-of-subsets removes systematic variation associated with the location of a gene on the array and/or the level of its expression. This procedure is easy to implement using iteratively reweighted least-squares algorithms. Although less sophisticated than lowess, this procedure works nearly as well for normalizing intensities based upon their magnitude. Unlike lowess, it can adjust for location-dependent effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA & Cell Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - NUCLEIC acids
KW - GENE expression
KW - GENETIC regulation
N1 - Accession Number: 15109747; Delongchamp, Robert R. 1; Email Address: rdelongchamp@nctr.fda.gov Velasco, Cruz 2 Razzaghi, Mehdi 1,3 Harris, Angela 1 Casciano, Dan 1; Affiliation: 1: National Center for Toxicological Research, Jefferson, Arkansas 2: Louisiana State University Health Sciences Center, New Orleans, Louisiana 3: Bloomsburg University, Bloomsburg, Pennsylvania; Source Info: Oct2004, Vol. 23 Issue 10, p653; Subject Term: DNA; Subject Term: NUCLEIC acids; Subject Term: GENE expression; Subject Term: GENETIC regulation; Number of Pages: 7p; Document Type: Article
L3 - 10.1089/1044549042476820
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15109747&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Hong
AU - Tong, Weida
AU - Shi, Leming
AU - Jakab, Robert L.
AU - Bowyer, John F.
T1 - Classification of cDNA Array Genes That Have a Highly Significant Discriminative Power Due to Their Unique Distribution in Four Brain Regions.
JO - DNA & Cell Biology
JF - DNA & Cell Biology
Y1 - 2004/10//
VL - 23
IS - 10
M3 - Article
SP - 661
EP - 674
PB - Mary Ann Liebert, Inc.
SN - 10445498
AB - Novel statistical methods were used to distinguish functionally distinct brain regions using their cDNA array gene expression profiles, and it was found that one of four specific factors is often associated with the most regionally discriminative genes. The gene expression profiles for the substantia nigra (SN), striatum (STR), parietal cortex (PC), and posterolateral cortical amygdaloid nucleus (PLCo) brain regions were determined from each brain region. An F-test identified 339 genes of the 1185 array genes as having a P≥ 0.01 and applied a gene ranking and selection method based on Soft Independent Modeling of Class Analogy (SIMCA) to obtain 59 of the most discriminative genes. Their discriminative power was validated in three steps. The most convincing step showed their ability to correctly predict the brain regional classifications for 18 "test" gene expression sets obtained from the four regions. A two-way Hierarchical Cluster Analysis organized the 59 genes in six clusters according to their expression differences in the brain regions. Expression patterns in the SN and STR regions greatly differed from each other and the PC and PLCo. The closer similarity in the gene expression patterns of the PC and PLCo was probably due to their functional similarity. The important factors in determining differences in the regional gene expression profiles in six clusters were (1) regional myelin/ oligodendrocyte levels, (2) resident neuron types, (3) neurotransmitter innervation profiles, and (4) Ca++-dependent signaling and second messenger systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA & Cell Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - MOLECULAR genetics
KW - GENE expression
KW - GENETIC regulation
KW - HEREDITY
N1 - Accession Number: 15109746; Fang, Hong 1 Tong, Weida 2 Shi, Leming 2 Jakab, Robert L. 3 Bowyer, John F. 3; Email Address: jbowyer@nctr.fda.gov; Affiliation: 1: Northrop Gruman Information Technology, Jefferson, Arkansas 2: Center for Toxicoinformatics, Division of Biometry and Risk Assessment, National Center for Toxicological Research (NCTR), FDA, Jefferson, Arkansas 3: Division of Neurotoxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, Arkansas; Source Info: Oct2004, Vol. 23 Issue 10, p661; Subject Term: GENES; Subject Term: MOLECULAR genetics; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: HEREDITY; Number of Pages: 14p; Document Type: Article
L3 - 10.1089/1044549042476875
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15109746&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hong, Huixiao
AU - Tong, Weida
AU - Perkins, Roger
AU - Fang, Hong
AU - Xie, Qian
AU - Shi, Leming
T1 - Multiclass Decision Forest—A Novel Pattern Recognition Method for Multiclass Classification in Microarray Data Analysis.
JO - DNA & Cell Biology
JF - DNA & Cell Biology
Y1 - 2004/10//
VL - 23
IS - 10
M3 - Article
SP - 685
EP - 694
PB - Mary Ann Liebert, Inc.
SN - 10445498
AB - The wealth of knowledge imbedded in gene expression data from DNA microarrays portends rapid advances in both research and clinic. Turning the prodigious and noisy data into knowledge is a challenge to the field of bioinformatics, and development of classifiers using supervised learning techniques is the primary methodological approach for clinical application using gene expression data. In this paper, we present a novel classification method, multiclass Decision Forest (DF), that is the direct extension of the two-class DF previously developed in our lab. Central to DF is the synergistic combining of multiple heterogenic but comparable decision trees to reach a more accurate and robust classification model. The computationally inexpensive multiclass DF algorithm integrates gene selection and model development, and thus eliminates the bias of gene preselection in crossvalidation. Importantly, the method provides several statistical means for assessment of prediction accuracy, prediction confidence, and diagnostic capability. We demonstrate the method by application to gene expression data for 83 small round blue-cell tumors (SRBCTs) samples belonging to one of four different classes. Based on 500 runs of 10-fold crossvalidation, tumor prediction accuracy was ~97%, sensitivity was ~95%, diagnostic sensitivity was ~91%, and diagnostic accuracy was ~99.5%. Among 25 genes selected to distinguish tumor class, 12 have functional information in the literature implicating their involvement in cancer. The four types of SRBCTs samples are also distinguishable in a clustering analysis based on the expression profiles of these 25 genes. The results demonstrated that the multiclass DF is an effective classification method for analysis of gene expression data for the purpose of molecular diagnostics. [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA & Cell Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DECISION making
KW - PATTERN recognition systems
KW - PATTERN perception
KW - DNA microarrays
KW - IMMOBILIZED nucleic acids
KW - GENE expression
KW - GENETIC regulation
N1 - Accession Number: 15109758; Hong, Huixiao 1 Tong, Weida 2; Email Address: wtong@nctr.fda.gov Perkins, Roger 1 Fang, Hong 1 Xie, Qian 1 Shi, Leming 2; Affiliation: 1: Bioinformatics Laboratory 2: Center for Toxicoinformatics, National Center for Toxicological Research, FDA, Jefferson, Arkansas; Source Info: Oct2004, Vol. 23 Issue 10, p685; Subject Term: DECISION making; Subject Term: PATTERN recognition systems; Subject Term: PATTERN perception; Subject Term: DNA microarrays; Subject Term: IMMOBILIZED nucleic acids; Subject Term: GENE expression; Subject Term: GENETIC regulation; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Document Type: Article
L3 - 10.1089/1044549042476839
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15109758&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawson, Christina C.
AU - Schnorr, Teresa M.
AU - Whelan, Elizabeth A.
AU - Deddens, James A.
AU - Dankovic, David A.
AU - Piacitelli, Laurie A.
AU - Sweeney, Marie H.
AU - Connally, L. Barbara
T1 - Paternal Occupational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Birth Outcomes of Offspring: Birth Weight, Preterm Delivery, and Birth Defects.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/10//
VL - 112
IS - 14
M3 - Article
SP - 1403
EP - 1408
PB - Superintendent of Documents
SN - 00916765
AB - Agent Orange is a phenoxy herbicide that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We studied pregnancy outcomes among wives of male chemical workers who were highly exposed to chemicals contaminated with TCDD and among wives of nonexposed neighborhood referents. For exposed pregnancies, we estimated serum TCDD concentration at the time of conception using a pharmacokinetic model. The mean TCDD concentration fin workers' births was 254 μg/g lipid (range, 3-16,340 μg/g). The mean referent concentration 0.16 μg/g was assigned to pregnancies fathered by workers before exposure. A total of 1,117 live singleton births of 217 referent wives and 176 worker wives were included. Only full-term births were included in the birth weight analysis ( 37 weeks of gestation). Mean birth weight among hill-term babies was similar among referents' babies (n = 604), pre-exposure workers' babies (n = 221), and exposed workers' babies (n = 292) (3,420, 3,347, and 3,442 g, respectively). Neither continuous nor categorical TCDD concentration had an effect on birth weight kr term infants after adjustment kr infant sex, mother's education, parity, prenatal cigarette smoking, and gestation length. An analysis to estimate potential direct exposure of the wives during periods of workers' exposure yielded a nonstatistically significant increase in infant birth weight of 130 g in the highest exposure group (TCDD concentration > 254 μg/g) compared with referents (p = 0.09). Mothers' reports of preterm delivery showed a somewhat protective association with paternal TCDD (log) concentration (odds ratio = 0.8; 95% confidence interval, 0.6-1.1). We also include descriptive information on reported birth defects. Because the estimated TCDD concentrations in this population were much higher than in other studies, the results indicate that TCDD is unlikely to increase the risk of low birth weight or preterm delivery through a paternal mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Human abnormalities
KW - Newborn infants
KW - Chemical workers
KW - Male employees
KW - Birth weight
KW - Premature labor
KW - birth defects
KW - birth weight
KW - congenital anomalies
KW - dioxin
KW - occupation
KW - paternal exposure
KW - preterm birth
KW - TCDD.
N1 - Accession Number: 14941530; Lawson, Christina C. 1; Email Address: CJL9@cdc.gov; Schnorr, Teresa M. 1; Whelan, Elizabeth A. 1; Deddens, James A. 1; Dankovic, David A. 1; Piacitelli, Laurie A. 1; Sweeney, Marie H. 2; Connally, L. Barbara 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; 2: Office of Global Health Affairs, Department of Health and Human Services, Hanoi, Vietnam.; Issue Info: Oct2004, Vol. 112 Issue 14, p1403; Thesaurus Term: Human abnormalities; Subject Term: Newborn infants; Subject Term: Chemical workers; Subject Term: Male employees; Subject Term: Birth weight; Subject Term: Premature labor; Author-Supplied Keyword: birth defects; Author-Supplied Keyword: birth weight; Author-Supplied Keyword: congenital anomalies; Author-Supplied Keyword: dioxin; Author-Supplied Keyword: occupation; Author-Supplied Keyword: paternal exposure; Author-Supplied Keyword: preterm birth; Author-Supplied Keyword: TCDD.; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.7051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14941530&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106593535
T1 - Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects.
AU - Lawson CC
AU - Schnorr TM
AU - Whelan EA
AU - Deddens JA
AU - Dankovic DA
AU - Piacitelli LA
AU - Sweeney MH
AU - Connally LB
Y1 - 2004/10//
N1 - Accession Number: 106593535. Language: English. Entry Date: 20050311. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Birth Weight -- Drug Effects
KW - Herbicides -- Adverse Effects
KW - Paternal Exposure -- Adverse Effects
KW - Abnormalities -- Etiology
KW - Adolescence
KW - Adult
KW - Analysis of Variance
KW - Childbirth, Premature -- Chemically Induced
KW - Descriptive Statistics
KW - Female
KW - Infant, Newborn
KW - Male
KW - Secondary Analysis
KW - Human
SP - 1403
EP - 1408
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 112
IS - 14
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - Agent Orange is a phenoxy herbicide that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We studied pregnancy outcomes among wives of male chemical workers who were highly exposed to chemicals contaminated with TCDD and among wives of nonexposed neighborhood referents. For exposed pregnancies, we estimated serum TCDD concentration at the time of conception using a pharmacokinetic model. The mean TCDD concentration for workers' births was 254 pg/g lipid (range, 3-16,340 pg/g). The mean referent concentration of 6 pg/g was assigned to pregnancies fathered by workers before exposure. A total of 1,117 live singleton births of 217 referent wives and 176 worker wives were included. Only full-term births were included in the birth weight analysis (greater than or equal to 37 weeks of gestation). Mean birth weight among full-term babies was similar among referents' babies (n = 604), preexposure workers' babies (n = 221), and exposed workers' babies (n = 292) (3,420, 3,347, and 3,442 g, respectively). Neither continuous nor categorical TCDD concentration had an effect on birth weight for term infants after adjustment for infant sex, mother's education, parity, prenatal cigarette smoking, and gestation length. An analysis to estimate potential direct exposure of the wives during periods of workers' exposure yielded a nonstatistically significant increase in infant birth weight of 130 g in the highest exposure group (TCDD concentration > 254 pg/g) compared with referents (p = 0.09). Mothers' reports of preterm delivery showed a somewhat protective association with paternal TCDD (log) concentration (odds ratio = 0.8; 95% confidence interval, 0.6-1.1). We also include descriptive information on reported birth defects. Because the estimated TCDD concentrations in this population were much higher than in other studies, the results indicate that TCDD is unlikely to increase the risk of low birth weight or preterm delivery through a paternal mechanism.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-15), Cincinnati, OH 45226; CJL9@cdc.gov
U2 - PMID: 15471733.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Delogu, Giovanni
AU - Bua, Alessandra
AU - Pusceddu, Cinzia
AU - Parra, Marcela
AU - Fadda, Giovanni
AU - Brennan, Michael J.
AU - Zanetti, Stefania
T1 - Expression and purification of recombinant methylated HBHA in Mycobacterium smegmatis
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2004/10//
VL - 239
IS - 1
M3 - Article
SP - 33
EP - 39
SN - 03781097
AB - The Heparin-Binding Haemagglutinin (HBHA) is a mycobacterial adhesin involved in the dissemination of Mycobacterium tuberculosis from the site of primary infection and a potential candidate for the development of a new vaccine against tuberculosis. Methylation of HBHA is a novel post-translational event that imparts important immunological properties to the protein. Since recombinant HBHA expressed in Escherichia coli is not methylated, we investigated the possibility of producing recombinant methylated HBHA in fast growing mycobacteria for use in immunological and biochemical studies. The complete coding sequence of HBHA was cloned in the plasmid pMV206, under the control of a strong promoter (hsp60) or its own promoter. The constructs generated were electroporated into Mycobacterium smegmatis and the recombinant strains obtained were analyzed for the presence of the HBHA protein using the anti-HBHA monoclonal antibodies D2 and E4. Our results indicate that expression of high amounts of intact protein can be toxic for the mycobacteria, that methylated HBHA can be obtained in M. smegmatis only when using a promoter sequence weaker than hsp60 and that the expression of the complete structural gene is required in order to obtain methylated HBHA. We constructed a recombinant M. smegmatis strain (pMV3-38) that expresses a histidine-tagged methylated HBHA that can be easily purified. The use of fast-growing strains of M. smegmatis to obtain significant amounts of purified HBHA protein within a short timeframe, should be an effective strategy for the evaluation of a new HBHA-based vaccine candidate for tuberculosis. [Copyright &y& Elsevier]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacteria
KW - Vaccination
KW - Escherichia
KW - Mycobacterium
KW - HBHA
KW - Methylation
KW - Protein expression
KW - Tuberculosis
KW - Vaccine
N1 - Accession Number: 14513157; Delogu, Giovanni; Email Address: gdelogu@rm.unicatt.it; Bua, Alessandra 1; Pusceddu, Cinzia 2; Parra, Marcela 3; Fadda, Giovanni 2; Brennan, Michael J. 3; Zanetti, Stefania 1; Affiliations: 1: Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari; 2: Institute of Microbiology, Catholic University, Rome; 3: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Issue Info: Oct2004, Vol. 239 Issue 1, p33; Thesaurus Term: Mycobacteria; Thesaurus Term: Vaccination; Thesaurus Term: Escherichia; Subject Term: Mycobacterium; Author-Supplied Keyword: HBHA; Author-Supplied Keyword: Methylation; Author-Supplied Keyword: Protein expression; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.femsle.2004.08.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kraeling, M.E.K.
AU - Yourick, J.J.
AU - Bronaugh, R.L.
T1 - In vitro human skin penetration of diethanolamine
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2004/10//
VL - 42
IS - 10
M3 - Article
SP - 1553
EP - 1561
SN - 02786915
AB - Concerns about the safety of diethanolamine (DEA) have been raised by the National Toxicology Program (NTP). Therefore, we measured the extent of DEA absorption in human skin relevant to exposures from shampoos, hair dyes and body lotions. Radiolabeled [14C]-DEA was added to two commercial products from each class and applied to excised viable and non-viable human skin in flow-through diffusion cells. The products remained on the skin for 5, 30 and 24 h for shampoos, hair dyes and body lotions, respectively. After 24 h, most of the absorbed dose was found in skin: 2.8% for shampoos, 2.9% for hair dyes and 10.0% for body lotions. Only small amounts were absorbed into the receptor fluid: 0.08%, 0.09% and 0.9% for shampoos, hair dyes and body lotions respectively. There was no significant difference in the absorption of DEA through viable and non-viable skin or from product application doses of 1, 2 or 3 mg lotion/cm2. In 72 h daily repeat dose studies with a lotion, DEA appeared to accumulate in the skin (29.2%) with little diffusing out into the receptor fluid. Therefore, skin levels of DEA should not be included in estimates of systemic absorption used in exposure assessments. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINES
KW - ORGANIC compounds
KW - SHAMPOOS
KW - HAIR -- Dyeing & bleaching
KW - TOXICOLOGY
KW - BSA, bovine serum albumin
KW - CIR, Cosmetic Ingredient Review Expert Panel
KW - CTFA, The Cosmetic, Toiletry, and Fragrance Association
KW - DEA, diethanolamine
KW - Diethanolamine (DEA)
KW - HHBSS, HEPES-buffered Hanks' balanced salt solution
KW - HPLC, high-performance liquid chromatography
KW - Human skin
KW - LSC, liquid scintillation counting
KW - NTP, National Toxicology Program
KW - PDA, photodiode array detector
KW - Percutaneous absorption
KW - Percutaneous penetration
KW - TEA, triethanolamine
KW - TLC, thin-layer chromatography
N1 - Accession Number: 14034254; Kraeling, M.E.K.; Email Address: margaret.kraeling@cfsan.fda.gov Yourick, J.J. 1 Bronaugh, R.L. 1; Affiliation: 1: Office of Cosmetics and Colors, US Food and Drug Administration, BRF HFS-128, 8301 Muirkirk Rd, Laurel, MD 20708, USA; Source Info: Oct2004, Vol. 42 Issue 10, p1553; Subject Term: AMINES; Subject Term: ORGANIC compounds; Subject Term: SHAMPOOS; Subject Term: HAIR -- Dyeing & bleaching; Subject Term: TOXICOLOGY; Author-Supplied Keyword: BSA, bovine serum albumin; Author-Supplied Keyword: CIR, Cosmetic Ingredient Review Expert Panel; Author-Supplied Keyword: CTFA, The Cosmetic, Toiletry, and Fragrance Association; Author-Supplied Keyword: DEA, diethanolamine; Author-Supplied Keyword: Diethanolamine (DEA); Author-Supplied Keyword: HHBSS, HEPES-buffered Hanks' balanced salt solution; Author-Supplied Keyword: HPLC, high-performance liquid chromatography; Author-Supplied Keyword: Human skin; Author-Supplied Keyword: LSC, liquid scintillation counting; Author-Supplied Keyword: NTP, National Toxicology Program; Author-Supplied Keyword: PDA, photodiode array detector; Author-Supplied Keyword: Percutaneous absorption; Author-Supplied Keyword: Percutaneous penetration; Author-Supplied Keyword: TEA, triethanolamine; Author-Supplied Keyword: TLC, thin-layer chromatography; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2004.04.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14034254&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de Jager, L. S.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
T1 - LC-UV and LC-MS analysis of food and drink products containing kava.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2004/10//
VL - 21
IS - 10
M3 - Article
SP - 921
EP - 934
PB - Taylor & Francis Ltd
SN - 0265203X
AB - A method for the determination of six kava lactones, methysticin, dihydromethysticin, kawain, dihydrokawain, yangonin and desmethoxyyangonin, in solid foods and beverages has been developed. Solid samples were prepared using methanol extraction, while beverages were extracted using a separate solid phase extraction (SPE) method. After sample preparation, the extracts were analysed using LC-UV or atmospheric pressure photoionization (APPI) LC-MS in the positive mode. Using the method, 10 beverage products, two chocolate products, three unbrewed tea products, three dietary supplements and a drink mix product were analysed. The results obtained using the LC-UV were comparable to those obtained using APPI-LC-MS for most products. Using the SPE method in conjunction with LC-MS, individual kava lactones were detected in drink products at ppb concentrations. Concentrations of total kava lactones ranged between 135-0.035 mg per serving in the food and beverage products tested and between 40-61 mg per serving for the dietary supplement products tested. Results of these analyses as well as extraction efficiency and reproducibility data are reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food additives
KW - Food contamination
KW - Food adulteration & inspection
KW - Food -- Safety measures
KW - Kava (Beverage)
KW - Beverages
KW - food analysis
KW - kava
KW - kava lactones
KW - LC-MS
KW - Piper methysticum
N1 - Accession Number: 15328360; de Jager, L. S. 1; Email Address: ldejager@cfsan.fda.gov; Perfetti, G. A. 1; Diachenko, G. W. 1; Affiliations: 1: US Food and Drug Administration, Centre for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD, USA; Issue Info: Oct2004, Vol. 21 Issue 10, p921; Thesaurus Term: Food additives; Thesaurus Term: Food contamination; Thesaurus Term: Food adulteration & inspection; Thesaurus Term: Food -- Safety measures; Subject Term: Kava (Beverage); Subject Term: Beverages; Author-Supplied Keyword: food analysis; Author-Supplied Keyword: kava; Author-Supplied Keyword: kava lactones; Author-Supplied Keyword: LC-MS; Author-Supplied Keyword: Piper methysticum; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - de Jager, L. S.
AU - Perfetti, G. A.
AU - Diachenko, G. W.
T1 - LC-UV and LC-MS analysis of food and drink products containing kava.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2004/10//
VL - 21
IS - 10
M3 - Article
SP - 921
EP - 934
PB - Taylor & Francis Ltd
SN - 0265203X
AB - A method for the determination of six kava lactones, methysticin, dihydromethysticin, kawain, dihydrokawain, yangonin and desmethoxyyangonin, in solid foods and beverages has been developed. Solid samples were prepared using methanol extraction, while beverages were extracted using a separate solid phase extraction (SPE) method. After sample preparation, the extracts were analysed using LC-UV or atmospheric pressure photoionization (APPI) LC-MS in the positive mode. Using the method, 10 beverage products, two chocolate products, three unbrewed tea products, three dietary supplements and a drink mix product were analysed. The results obtained using the LC-UV were comparable to those obtained using APPI-LC-MS for most products. Using the SPE method in conjunction with LC-MS, individual kava lactones were detected in drink products at ppb concentrations. Concentrations of total kava lactones ranged between 135-0.035 mg per serving in the food and beverage products tested and between 40-61 mg per serving for the dietary supplement products tested. Results of these analyses as well as extraction efficiency and reproducibility data are reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KAVA (Beverage)
KW - FOOD additives
KW - BEVERAGES
KW - FOOD contamination
KW - FOOD adulteration & inspection
KW - FOOD -- Safety measures
KW - food analysis
KW - kava
KW - kava lactones
KW - LC-MS
KW - Piper methysticum
N1 - Accession Number: 15328360; de Jager, L. S. 1; Email Address: ldejager@cfsan.fda.gov Perfetti, G. A. 1 Diachenko, G. W. 1; Affiliation: 1: US Food and Drug Administration, Centre for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD, USA; Source Info: Oct2004, Vol. 21 Issue 10, p921; Subject Term: KAVA (Beverage); Subject Term: FOOD additives; Subject Term: BEVERAGES; Subject Term: FOOD contamination; Subject Term: FOOD adulteration & inspection; Subject Term: FOOD -- Safety measures; Author-Supplied Keyword: food analysis; Author-Supplied Keyword: kava; Author-Supplied Keyword: kava lactones; Author-Supplied Keyword: LC-MS; Author-Supplied Keyword: Piper methysticum; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Begley, T. H.
AU - Biles, J. E.
AU - Cunningham, C.
AU - Piringer, O.
T1 - Migration of a UV stabilizer from polyethylene terephthalate (PET) into food simulants.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2004/10//
VL - 21
IS - 10
M3 - Article
SP - 1007
EP - 1014
PB - Taylor & Francis Ltd
SN - 0265203X
AB - The migration characteristics of the UV stabilizer Tinuvin 234 (2-(2H-benzotriazol-2-yl)-4,6-bis (1-methyl-1-phenylethyl)phenol) into food simulants has been measured from polyethylene terephthalate (PET) using HPLC with UV detection. Ethanol/water, isooctane and a fractionated coconut oil simulant (Miglyol®) were used as food simulating solvents. The migration characteristics were measured at temperatures in the range of 40-70°C. Diffusion coefficients were determined to be in the range of 1 × 10 -14 cm 2 s -1 to 1 × 10 -18 cm 2 s -1 . At 40°C, the amount of migration into 95% ethanol after 10 days was 2 μg dm -2 . Isooctane is determined to be a good fatty food simulant that provides similar results for PET to those of fatty foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Stabilizing agents
KW - Polyethylene terephthalate
KW - Food contamination
KW - Contamination (Technology)
KW - Food adulteration & inspection
KW - Food -- Safety measures
KW - diffusion
KW - food packaging
KW - food simulants
KW - Migration
KW - polyethylene terephthalate
KW - UV stabilizers
N1 - Accession Number: 15328363; Begley, T. H. 1; Email Address: timothy.begley@cfsan.fda.gov; Biles, J. E. 1; Cunningham, C. 1; Piringer, O. 2; Affiliations: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; 2: Fabes GmbH, Schragenhofstr, 35, D-80992, Munich, Germany; Issue Info: Oct2004, Vol. 21 Issue 10, p1007; Thesaurus Term: Stabilizing agents; Thesaurus Term: Polyethylene terephthalate; Thesaurus Term: Food contamination; Thesaurus Term: Contamination (Technology); Thesaurus Term: Food adulteration & inspection; Thesaurus Term: Food -- Safety measures; Author-Supplied Keyword: diffusion; Author-Supplied Keyword: food packaging; Author-Supplied Keyword: food simulants; Author-Supplied Keyword: Migration; Author-Supplied Keyword: polyethylene terephthalate; Author-Supplied Keyword: UV stabilizers; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325220 Artificial and Synthetic Fibers and Filaments Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Castranova, Vincent
T1 - Signaling Pathways Controlling The Production Of Inflammatory Mediators in Response To Crystalline Silica Exposure: Role Of Reactive Oxygen/Nitrogen Species
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2004/10//
VL - 37
IS - 7
M3 - Article
SP - 916
EP - 925
SN - 08915849
AB - Occupational exposure to crystalline silica has been linked to pulmonary fibrosis and lung cancer. Surface properties of crystalline silica are critical to the production of oxidant species, chemokines, inflammatory cytokines, and proliferative factors involved in the initiation and progression of silica-induced damage, inflammation, alveolar type II cell hyperplasia, fibroblast activation, and disease. The transcription factors nuclear factor κB (NF-κB) and activator protein 1 (AP-1) have been shown to play key roles in gene promotion for inflammatory mediators, oncogenes, and growth factors. This review summarizes evidence that in vitro and in vivo exposure to crystalline silica results in activation of NF-κB and AP-1. Signaling pathways for activation of these transcription factors are described. In addition, the role of silica-induced reactive oxygen species and nitric oxide in the activation of these signaling events is presented. Last, the generalizability of mechanisms regulating silica-induced pulmonary responses to pulmonary reactions to other occupational particles is discussed. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - PROTEINS
KW - LUNG diseases
KW - NITROGEN
KW - Fibers
KW - Free radicals
KW - Reactive oxygen species
KW - Signaling pathways
KW - Silica
KW - Transcription factors
N1 - Accession Number: 14271019; Castranova, Vincent 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Oct2004, Vol. 37 Issue 7, p916; Subject Term: CYTOKINES; Subject Term: PROTEINS; Subject Term: LUNG diseases; Subject Term: NITROGEN; Author-Supplied Keyword: Fibers; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Signaling pathways; Author-Supplied Keyword: Silica; Author-Supplied Keyword: Transcription factors; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2004.05.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilson, Willie
AU - Pardo-Manuel de Villena, Fernando
AU - Lyn-Cook, Beverly D.
AU - Chatterjee, Pradeep K.
AU - Bell, Timothy A.
AU - Detwiler, David A.
AU - Gilmore, Rodney C.
AU - Valladeras, Isis C.
AU - Wright, Camille C.
AU - Threadgill, David W.
AU - Grant, Delores J.
T1 - Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15
JO - Genomics
JF - Genomics
Y1 - 2004/10//
VL - 84
IS - 4
M3 - Article
SP - 707
EP - 714
SN - 08887543
AB - Members of the human UDP-glucuronosyltransferase 2B family are located in a cluster on chromosome 4q13 and code for enzymes whose gene products are responsible for the normal catabolism of steroid hormones. Two members of this family, UGT2B15 and UGT2B17, share over 95% sequence identity. However, UGT2B17 exhibits broader substrate specificity due to a single amino acid difference. Using gene-specific primers to explore the genomic organization of these two genes, it was determined that UGT2B17 is absent in some human DNA samples. The gene-specific primers demonstrated the presence or absence of a 150 kb genomic interval spanning the entire UGT2B17 gene, revealing that UGT2B17 is present in the human genome as a deletion polymorphism linked to UGT2B15. Furthermore, it is shown that the UGT2B17 deletion polymorphism shows Mendelian segregation and allele frequencies that differ between African Americans and Caucasians. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - STEROID hormones
KW - HUMAN genome
KW - UNITED States
KW - Duplicate genes
KW - Gene deletion
KW - Genetic diversity
KW - Genetic variation
KW - Polymorphisms (genetics)
KW - UDP Glucuronosyltransferase
N1 - Accession Number: 14650240; Wilson, Willie 1 Pardo-Manuel de Villena, Fernando 2 Lyn-Cook, Beverly D. 3 Chatterjee, Pradeep K. 4 Bell, Timothy A. 2 Detwiler, David A. 2 Gilmore, Rodney C. 1 Valladeras, Isis C. 1 Wright, Camille C. 1 Threadgill, David W. 2 Grant, Delores J. 1; Email Address: dgrant@wpo.nccu.edu; Affiliation: 1: Cancer Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USA 2: Department of Genetics, Lineberger Comprehensive Cancer Center and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 3: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AK, USA 4: Genomics Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USA; Source Info: Oct2004, Vol. 84 Issue 4, p707; Subject Term: GENETIC polymorphisms; Subject Term: STEROID hormones; Subject Term: HUMAN genome; Subject Term: UNITED States; Author-Supplied Keyword: Duplicate genes; Author-Supplied Keyword: Gene deletion; Author-Supplied Keyword: Genetic diversity; Author-Supplied Keyword: Genetic variation; Author-Supplied Keyword: Polymorphisms (genetics); Author-Supplied Keyword: UDP Glucuronosyltransferase; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ygeno.2004.06.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn M.
AU - Slutsky, Jean R.
AU - Patton, Larry T.
AD - Agency for Healthcare Research and Quality
AD - Unlisted
AD - Unlisted
T1 - Evidence-Based Health Care 2004: AHRQ Moves Research to Translation and Implementation
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/10//
VL - 39
IS - 5
SP - xv
EP - xxiii
SN - 00179124
N1 - Accession Number: 0761378; Keywords: Health Care; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200502
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Lau, Denys T.
AU - Kasper, Judith D.
AU - Potter, D. E. B.
AU - Lyles, Alan
AD - U MI
AD - Johns Hopkins U
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - U Baltimore
T1 - Potentially Inappropriate Medication Prescriptions among Elderly Nursing Home Residents: Their Scope and Associated Resident and Facility Characteristics
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/10//
VL - 39
IS - 5
SP - 1257
EP - 1276
SN - 00179124
N1 - Accession Number: 0761380; Keywords: Elderly; Medicine; Nursing; Prescription; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200502
N2 - The PIRx, defined by Beers's consensus criteria (1991, 1997), was identified using up to a year's worth of NH prescribed medicine data for each resident. The study sample represented 1.6 million NH residents (n = 3,372). At a minimum, 50 percent of all residents aged 65 or older, with an NH stay of three months or longer received at least one PIRx in 1996. The most common PIRx involved propoxyphene, diphenhydramine, hydroxyzine, oxybutynin, amitriptyline, cyproheptadine, iron supplements, and ranitidine. Resident factors associated with greater odds of PIRx were Medicaid coverage, no high school diploma, and nondementia mental disorders. Facility factors were more beds and lower RN-to-resident ratio. Factors associated with lower odds of PIRx were fewer medications, residents with communication problems, and being in an accredited NH. Onsite availability of pharmacists or mental health providers was not related.
KW - Analysis of Health Care Markets I11
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106586363
T1 - Rapid induction of protective tolerance to potential terrorist agents: a systematic review of low- and ultra-low dose research.
AU - Szeto AL
AU - Rollwagen F
AU - Jonas WB
Y1 - 2004/10//2004 Oct
N1 - Accession Number: 106586363. Language: English. Entry Date: 20050225. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Alternative/Complementary Therapies; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Samueli Institute for Information Biology and NIH [NCCAM] grant R21 AT00350-01A1. NLM UID: 101140517.
KW - Biological Warfare -- Prevention and Control
KW - Chemical Warfare Agents -- Metabolism
KW - Homeopathy -- Methods
KW - CINAHL Database
KW - Disaster Planning -- Methods
KW - Funding Source
KW - Medline
KW - Study Design
KW - Toxicology
KW - Human
SP - 173
EP - 178
JO - Homeopathy
JF - Homeopathy
JA - HOMEOPATHY
VL - 93
IS - 4
PB - Churchill Livingstone, Inc.
AB - OBJECTIVE: To systematically review the literature on the ability of low-dose (LD) and ultra-low-dose (ULD) toxin exposure to prevent and treat biological and chemical threats. METHODS: Laboratory research articles on protection or treatment from LD or ULD exposure for the 13 high-risk chemical and biological warfare threats were collected and systematically evaluated for quantity and scientific quality using pre-defined methodological criteria. RESULTS: Over 2600 articles were screened. Only five studies met the inclusion criteria examining stimulation and protective effects of LD- or ULD-exposures to the 13 pre-identified biological and chemical agents. The quality evaluation (QE) of these studies was above average with a mean QE score of 70.6% of maximum. Two articles of fair to good quality reported both protective and treatment efficacy from exposure of animals or humans to LD- and ULD-exposures to toxins of risk in biochemical warfare. CONCLUSION: There is little research on agents of biological and chemical warfare investigating the possible use of LD- and ULD-toxins for protection and treatment. The existing literature is generally of good quality and indicates that rapid induction of protective tolerance is a feasible but under-investigated approach to bioterrorist or biowarfare defense. In our opinion, further research into the role of induced protection with LD- and ULD-toxic agents is needed.
SN - 1475-4916
AD - Food and Drug Administration, Rockville, MD
U2 - PMID: 15532694.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Burstin, Helen
AU - Clancy, Carolyn
T1 - Primary Care Experience.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2004/10//
VL - 19
IS - 10
M3 - Editorial
SP - 1064
EP - 1065
SN - 08848734
AB - This article presents a study, which focuses on primary health care. At the dawn of a new century, health care professionals confront the challenges of caring for an aging and increasingly diverse population, a patient population with more chronic illnesses and more treatment options, and significantly increased access to current scientific evidence. In theory, these challenges should reinforce the importance of primary care values and competencies. In practice, however, the daily experience of many primary care clinicians doesn't quite suggest a golden age. Primary care and general internal medicine needs careful growth and development.
KW - PRIMARY care (Medicine)
KW - MEDICAL care
KW - CHRONIC diseases
KW - MEDICAL personnel
KW - INTERNAL medicine
KW - DISEASES
N1 - Accession Number: 14641929; Burstin, Helen 1 Clancy, Carolyn 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Md.; Source Info: Oct2004, Vol. 19 Issue 10, p1064; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL care; Subject Term: CHRONIC diseases; Subject Term: MEDICAL personnel; Subject Term: INTERNAL medicine; Subject Term: DISEASES; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1111/j.1525-1497.2004.40702.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daniel K. Benjamin
AU - Steven Hirschfeld
AU - Coleen K. Cunningham
AU - Ross E. McKinney
T1 - Growth as a part of the composite endpoint in paediatric antiretroviral clinical trials.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2004/10//
VL - 54
IS - 4
M3 - Article
SP - 701
EP - 703
SN - 03057453
N1 - Accession Number: 20161238; Daniel K. Benjamin 1; Steven Hirschfeld 2; Coleen K. Cunningham 1; Ross E. McKinney 1; Affiliations: 1: Department of Pediatrics, Duke University, Durham, NC;; 2: Food and Drug Administration, Washington, DC, USA; Issue Info: Oct2004, Vol. 54 Issue 4, p701; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nano, Francis E.
AU - Na Zhang
AU - Cowley, Siobhán C.
AU - Klose, Karl E.
AU - Karen K. M. Cheung
AU - Roberts, Michael J.
AU - Ludu, Jagjit S.
AU - Letendre, Gregg W.
AU - Meierovics, Anda I.
AU - Stephens, Gwen
AU - Elkins, Karen L.
T1 - A Franc&ella tularens& Pathogenicity Island Required for Intramacrophage Growth.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2004/10//
VL - 186
IS - 19
M3 - Article
SP - 6430
EP - 6436
SN - 00219193
AB - Francisella tularensis is a gram-negative, facultative intracellular pathogen that causes the highly infectious zoonotic disease tularemia. We have discovered a ca. 30-kb pathogenicity island of F. tularensis (FPI) that includes four large open reading frames (ORFs) of 2.5 to 3.9 kb and 13 ORFs of 1.5 kb or smaller. Previously, two small genes located near the center of the FPI were shown to be needed for intramacrophage growth. In this work we show that two of the large ORFs, located toward the ends of the FPI, are needed for virulence. Although most genes in the FPI encode proteins with amino acid sequences that are highly conserved between high- and low-virulence strains, one of the FPI genes is present in highly virulent type A F. tularensis, absent in moderately virulent type B F. tularensis, and altered in F. tularensis subsp, novicida, which is highly virulent for mice but avirulent for humans. The G+C content of a 17.7-kb stretch of the FPI is 26.6%, which is 6.6% below the average G+C content of the F. tularensis genome. This extremely low G+C content suggests that the DNA was imported from a microbe with a very low G+C-containing chromosome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FRANCISELLA tularensis
KW - GRAM-negative bacteria
KW - PATHOGENIC microorganisms
KW - TULAREMIA
KW - MACROPHAGES
KW - AMINO acids
KW - GENOMES
N1 - Accession Number: 14746340; Nano, Francis E. 1; Email Address: fnano@uvic.ca. Na Zhang 1 Cowley, Siobhán C. 2 Klose, Karl E. 3 Karen K. M. Cheung 1 Roberts, Michael J. 1 Ludu, Jagjit S. 1 Letendre, Gregg W. 1 Meierovics, Anda I. 2 Stephens, Gwen 4 Elkins, Karen L. 2; Affiliation: 1: Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 3: Department of Microbiology and Immunology, University of Texas Health Sciences Center, San Antonio, Texas 4: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada; Source Info: Oct2004, Vol. 186 Issue 19, p6430; Subject Term: FRANCISELLA tularensis; Subject Term: GRAM-negative bacteria; Subject Term: PATHOGENIC microorganisms; Subject Term: TULAREMIA; Subject Term: MACROPHAGES; Subject Term: AMINO acids; Subject Term: GENOMES; Number of Pages: 7p; Illustrations: 4 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1128/JB.186.19.6430-6436.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung-Tung Jordan Lin
AU - Jonq-Ying Lee
T1 - Who Uses Food Label Information: A Case Study of Dietary Fat.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2004/10//
VL - 10
IS - 4
M3 - Article
SP - 17
EP - 37
SN - 10454446
AB - Consumer psychology suggests that fat intake and search for fat information on food labels may be mutually dependent. This study extends previous research by using a simultaneous-equation model to measure the relationship between fat intake and label use. Using the 1994-6 USDA CSII and DHKS data, our results suggest individuals who consume a higher percentage of calories from fat are less likely to report searching for fat information on food labels. We also identified the roles played by several psychological variables on information search and fat intake. These findings have important implications on nutrition education and effectiveness of food labels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Products Marketing is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - DIET
KW - FAT
KW - PERSONS
KW - PSYCHOLOGY
KW - CASE studies
KW - CSII
KW - dietary fat
KW - Food label
N1 - Accession Number: 15851381; Chung-Tung Jordan Lin 1; Email Address: clin@cfsan.fda.gov Jonq-Ying Lee 2; Email Address: jle@rnail.ifas.ufl.edu; Affiliation: 1: Consumer Science Specialist for Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park. 2: Senior Research Economist, Florida Department of Citrus, University of Florida, Gainesville, FL.; Source Info: 2004, Vol. 10 Issue 4, p17; Subject Term: FOOD labeling; Subject Term: DIET; Subject Term: FAT; Subject Term: PERSONS; Subject Term: PSYCHOLOGY; Subject Term: CASE studies; Author-Supplied Keyword: CSII; Author-Supplied Keyword: dietary fat; Author-Supplied Keyword: Food label; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 21p; Document Type: Article
L3 - 10.1300/J038v10n04-02
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15851381&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nordstrom, J. L.
AU - Kaysner, C. A.
AU - Blackstone, G. M.
AU - Vickery, M. C. L.
AU - Bowers, J. C.
AU - DePaola, A.
T1 - Effect of Intertidal Exposure on Vibrio parahaemolyticus Levels in Pacific Northwest Oysters.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/10//
VL - 67
IS - 10
M3 - Article
SP - 2178
EP - 2182
SN - 0362028X
AB - Interest in Vibrio parahaemolyticus (Vp) increased in the United States following Vp-associated gastroenteritis outbreaks in 1997 and 1998 involving the West Coast and other areas. The present study evaluated multiple aspects of Vp ecology in the Pacific Northwest with three objectives: (1) to determine the effect of low-tide exposure on Vp levels in oysters, (ii) to determine the relationship between total and pathogenic Vp, and (iii) to examine sediments and aquatic fauna as reservoirs for pathogenic Vp. Samples were collected from intertidal reefs along Hood Canal, Wash., in August 2001. Fecal matter from marine mammals and aquatic birds as well as intestinal contents from bottom-dwelling fish were tested. Total and pathogenic Vp levels in all the samples were enumerated with colony hybridization procedures using DNA probes that targeted the thermolabile direct hemolysin (tlh) and thermostable direct hemolysin (tdh) genes, respectively. The mean Vp densities in oysters were four to eight times greater at maximum exposure than at the corresponding first exposure. While tdh-positive Vp counts were generally ⩽10 CFU/g at first exposure, counts as high as 160 CFU/g were found at maximum exposure. Vp concentrations in sediments were not significantly different from those in oysters at maximum exposure. Pathogenic (tdh positive) Vp was detected in 9 of 42 (21%) oyster samples at maximum exposure, in 5 of 19 (26%) sediment samples, but in 0 of 9 excreta samples. These results demonstrate that summer conditions permit the multiplication of Vp in oysters exposed by a receding tide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters
KW - Pathogenic microorganisms
KW - Vibrio parahaemolyticus
KW - Gastroenteritis
KW - Nucleic acid probes
KW - Deoxyribonucleotides
N1 - Accession Number: 14896450; Nordstrom, J. L. 1; Email Address: jessica.nordstrom@cfsan.fda.gov; Kaysner, C. A. 2; Blackstone, G. M. 1; Vickery, M. C. L. 1; Bowers, J. C. 3; DePaola, A. 1; Affiliations: 1: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, I Iberville Drive, Dauphin Island, Alabama 36528-0158.; 2: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Drive S.E., Bothell, Washington 98021-4421.; 3: U.S. Food and Drug Administration, Division of Mathematics, CPKI RM 2D020, College Park, Maryland 20740, USA.; Issue Info: Oct2004, Vol. 67 Issue 10, p2178; Thesaurus Term: Oysters; Thesaurus Term: Pathogenic microorganisms; Subject Term: Vibrio parahaemolyticus; Subject Term: Gastroenteritis; Subject Term: Nucleic acid probes; Subject Term: Deoxyribonucleotides; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keller, Susanne E.
AU - Chirtel, Stuart J.
AU - Merker, Robert I.
AU - Taylor, Kirk T.
AU - Tan, Hsu Ling
AU - Miller, Arthur J.
T1 - Influence of Fruit Variety, Harvest Technique, Quality Sorting, and Storage on the Native Microflora of Unpasteurized Apple Cider.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/10//
VL - 67
IS - 10
M3 - Article
SP - 2240
EP - 2247
SN - 0362028X
AB - Apple variety, harvest, quality sorting, and storage practices were assessed to determine their impact on the microflora of unpasteurized cider. Seven apple varieties were harvested from the tree or the ground. The apples were used fresh or were stored at 0 to 4°C for ⩽5 months and were pressed with or without quality selection. Cider yield, pH, Brix value, and titratable acidity were measured. Apples, postpressing apple pomace, and cider samples were analyzed for aerobic bacteria, yeasts, and molds. Aerobic bacterial plate counts (APCs) of ciders from fresh ground-picked apples (4.89 log CFU/mI) were higher than those of ciders made from fresh, tree-picked apples (3.45 log CFU/ml). Quality sorting further reduced the average APC to 2.88 log CFU/ml. Differences among all three treatment groups were significant (P < 0.0001). Apple and pomace microbial concentrations revealed harvest and postharvest treatment-dependent differences similar to those found in cider. There were significant differences in APC among apple varieties (P = 0.0001). Lower counts were associated with varieties exhibiting higher Brix values and higher titratable acidity. Differences in APC for stored and fresh apples used for cider production were not significant (P > 0.05). Yeast and mold counts revealed relationships similar to those for APCs. The relationship between initial microbial load found on incoming fruit and final cider microbial population was curvilinear, with the weakest correlations for the lowest apple microflora concentrations. The lack of linearity suggests that processing equipment contributed to cider contamination. Tree-picked quality fruit should be used for unpasteurized cider production, and careful manufacturing practices at cider plants can impact both safety and quality of the final product. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Harvesting
KW - Apples
KW - POPULATION biology
KW - Fruit -- Quality
KW - Cider (Alcoholic beverage)
KW - Microorganisms
KW - Plate counts (Microbiology)
N1 - Accession Number: 14896459; Keller, Susanne E. 1; Chirtel, Stuart J. 2; Merker, Robert I. 2; Email Address: robert.merker@cfsan.fda.gov I 1 TT It ! Y!; Taylor, Kirk T. 3; Tan, Hsu Ling 4; Miller, Arthur J. 2; Affiliations: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Avenue, Summit-Argo, Illinois 60501.; 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park Maryland 20740.; 3: EI Dorado County Department of Agriculture, 311 Fair Lane, Placerville, California 95667.; 4: Department of Food Science and Technology, University of California, Davis, California 95616, USA.; Issue Info: Oct2004, Vol. 67 Issue 10, p2240; Thesaurus Term: Harvesting; Thesaurus Term: Apples; Thesaurus Term: POPULATION biology; Subject Term: Fruit -- Quality; Subject Term: Cider (Alcoholic beverage); Subject Term: Microorganisms; Subject Term: Plate counts (Microbiology); NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - RODRIGUEZ, A. C.
AU - LARKIN, J. W.
AU - DUNN, J.
AU - PATAZCA, E.
AU - REDDY, N. R.
AU - ALVAREZ-MEDINA, M.
AU - TETZLOFF, R.
AU - FLEISCHMAN, G. J.
T1 - Model of the Inactivation of Bacterial Spores by Moist Heat and High Pressure.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2004/10//
VL - 69
IS - 8
M3 - Article
SP - E367
EP - E373
SN - 00221147
AB - Formulae for the prediction of inactivation and accumulated lethality of bacterial spores under moist heat and high pressures were derived on the basis of classic thermodynamic and kinetics principles. The capability of the model to describe the inactivation of bacterial spores was verified using 2 independent data sets corresponding to Clostridium botulinum processed at 60°C to 75°C and Bacillus stearothermophilus processed at 92°C to 110°C. Both sets included pressures between 5 × 10 Pa and 7 × 10 Pa. The equation fit explained more than 86% of the variation of the rate constant data. The developed equations establish a strong foundation on which to compare high-pressure processing treatments of different systems. This is especially useful because most systems have different transient temperature-pressure conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIAL spores
KW - RESEARCH
KW - BACILLUS (Bacteria)
KW - CLOSTRIDIUM botulinum
KW - STERILIZATION (Disinfection)
KW - HIGH pressure (Technology)
KW - Bacillus stearothermophilus
KW - Clostridium botulinum
KW - high-pressure
KW - inactivation
KW - kinetics
KW - model
KW - shelf-stable
KW - spore
KW - sterilization
KW - terminal sterilization
N1 - Accession Number: 60467686; RODRIGUEZ, A. C. 1; Email Address: Alfredo_Rodriguez@baxter.com LARKIN, J. W. 2 DUNN, J. 3 PATAZCA, E. 3 REDDY, N. R. 2 ALVAREZ-MEDINA, M. 1 TETZLOFF, R. 3 FLEISCHMAN, G. J. 2; Affiliation: 1: Baxter Healthcare Corp., RLT-10, Route 120 and Wilson Rd., Round Lake, IL 60073 2: Food and Drug Administration, Natl. Center for Food Safety and Technology, Summit-Argo, Ill. 3: Natl. Center for Food Safety and Technology, Illinois Inst. of Technology, Summit-Argo, Ill.; Source Info: Oct2004, Vol. 69 Issue 8, pE367; Subject Term: BACTERIAL spores; Subject Term: RESEARCH; Subject Term: BACILLUS (Bacteria); Subject Term: CLOSTRIDIUM botulinum; Subject Term: STERILIZATION (Disinfection); Subject Term: HIGH pressure (Technology); Author-Supplied Keyword: Bacillus stearothermophilus; Author-Supplied Keyword: Clostridium botulinum; Author-Supplied Keyword: high-pressure; Author-Supplied Keyword: inactivation; Author-Supplied Keyword: kinetics; Author-Supplied Keyword: model; Author-Supplied Keyword: shelf-stable; Author-Supplied Keyword: spore; Author-Supplied Keyword: sterilization; Author-Supplied Keyword: terminal sterilization; Number of Pages: 7p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2621.2004.tb09897.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106573094
T1 - The first national reports on United States healthcare quality and disparities.
AU - Poker A
AU - Hubbard H
AU - Sharp BAC
Y1 - 2004/10//Oct-Nov2004
N1 - Accession Number: 106573094. Language: English. Entry Date: 20050128. Revision Date: 20150711. Publication Type: Journal Article; forms; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Quality of Health Care
KW - Reports
KW - United States Agency for Healthcare Research and Quality
KW - Conceptual Framework
KW - Health Services Accessibility
KW - Quality Improvement
SP - 316
EP - 321
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 19
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - In the Healthcare Research and Quality Act of 1999 (Public Law 106-129), Congress mandated that the Agency for Healthcare Research and Quality (AHRQ) produce annual reports on healthcare quality and disparities in the United States. The National Healthcare Quality Report and the National Healthcare Disparities Report were first released in 2003 by the AHRQ. These reports include broad sets of performance measures to portray the nation's progress toward improving the quality of care provided to all Americans. This article provides an overview of the framework, development, and future uses of the reports by consumers, practitioners, researchers, and policy makers.
SN - 1057-3631
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; apoker@ahrq.gov
U2 - PMID: 15535536.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106684606
T1 - Industries in the United States with airborne beryllium exposure and estimates of the number of current workers potentially exposed.
AU - Henneberger PK
AU - Goe SK
AU - Miller WE
AU - Doney B
AU - Groce DW
Y1 - 2004/10//
N1 - Accession Number: 106684606. Language: English. Entry Date: 20041119. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; research; tables/charts. Note: For CE see Suppl pages D117-8. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Beryllium -- Adverse Effects
KW - Occupational Hazards -- Evaluation -- United States
KW - Confidence Intervals
KW - Education, Continuing (Credit)
KW - National Institute for Occupational Safety and Health
KW - Occupational Exposure -- Evaluation
KW - United States
KW - United States Occupational Safety and Health Administration
KW - Human
SP - 648
EP - 659
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Estimates of the number of workers in the United States occupationally exposed to beryllium were published in the 1970s and 1980s and ranged from 21,200 to 800,000. We obtained information from several sources to identify specific industries with beryllium exposure and to estimate the number of current workers potentially exposed to beryllium. We spoke with representatives from the primary beryllium industry and government agencies about the number of exposed workers in their facilities. To identify industries in the private sector but outside the primary industry, we used data from the Integrated Management Information System (IMIS), which is managed by the Occupational Safety and Health Administration, and the Health Hazard Evaluation program of the National Institute for Occupational Safety and Health. We used IMIS data from OSHA inspections with a previously developed algorithm to estimate the number of potentially exposed workers in nonprimary industries. Workers potentially exposed to beryllium included 1500 current employees in the primary beryllium industry and 26,500 individuals currently working for the Department of Energy or the Department of Defense. We identified 108 four-digit Standard Industrial Classification (SIC) categories in which at least one measurement of airborne beryllium was 0.1 g/m3. Based on the subset of 94 SIC categories with beryllium 0.1 g/m3, we estimated 26,400 to 106,000 workers may be exposed in the private sector (outside the primary industry). In total, there are as many as 134,000 current workers in government and private industry potentially exposed to beryllium in the United States. We recommend that the results of this study be used to target at-risk audiences for hazard communications intended to prevent beryllium sensitization and chronic beryllium disease.
SN - 1545-9624
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS H-2800, Morgantown, WV 26505; pkh0@cdc.gov
U2 - PMID: 15631056.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106684602
T1 - Evaluation of a local exhaust ventilation system for controlling refractory ceramic fibers during disc sanding.
AU - Dunn KH
AU - Shulman SA
AU - Cecala AB
AU - Venturin DE
A2 - Mazzuckelli L
Y1 - 2004/10//
N1 - Accession Number: 106684602. Language: English. Entry Date: 20041119. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Ohio
KW - Ventilation -- Evaluation
KW - Case Studies
KW - Ohio
KW - Human
SP - D107
EP - 11
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 15631052.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Burgess, Jeffrey L.
AU - Fierro, Maria A.
AU - Lantz, R. Clark
AU - Hysong, Tracy A.
AU - Fleming, Joy E.
AU - Gerkin, Richard
AU - Hnizdo, Eva
AU - Conley, Shannon M.
AU - Klimecki, Walter
T1 - Longitudinal Decline in Lung Function: Evaluation of Interleukin-10 Genetic Polymorphisms in Firefighters.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2004/10//
VL - 46
IS - 10
M3 - Article
SP - 1013
EP - 1022
SN - 10762752
AB - During annual medical monitoring, some firefighters are found to have rates of decline in forced expiratory volume in one second (FEV1) far exceeding their peers. lnterleukin-10 (IL-10) suppresses inflammation, and single nucleotide polymorphisms (SNPs) in the IL-10 gene may confer variable susceptibility to more rapid decline in lung function. In 1204 firefighters with at least six annual FEV1 measurements, increased age and greater initial FEV1 were associated with more rapid decline in lung function. DNA collected from 379 of these firefighters was screened for IL-10 SNPs at -1117, -854, 919, 1668, and 1812. A statistically significant difference in decline in lung function was found based on genotyping at the 1668 SNP. Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS
KW - INTERLEUKIN-10
KW - GENETIC polymorphisms
KW - PHYSIOLOGY
KW - INFLAMMATION
KW - FIRE fighters
N1 - Accession Number: 14850919; Burgess, Jeffrey L. 1,2; Email Address: jburgess@u.arizona.edu Fierro, Maria A. 1 Lantz, R. Clark 1 Hysong, Tracy A. 1 Fleming, Joy E. 1 Gerkin, Richard 3 Hnizdo, Eva 4 Conley, Shannon M. 1 Klimecki, Walter 1; Affiliation: 1: University of Arizona, Tucson, Arizona 2: Environmental and Occupational Health, Mel and Enid Zuckerman Arizona College of Public Health, 1435 N. Fremont, Tucson, AZ 85719 3: Good Samaritan Medical Center, Phoenix, Arizona 4: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Oct2004, Vol. 46 Issue 10, p1013; Subject Term: LUNGS; Subject Term: INTERLEUKIN-10; Subject Term: GENETIC polymorphisms; Subject Term: PHYSIOLOGY; Subject Term: INFLAMMATION; Subject Term: FIRE fighters; Number of Pages: 10p; Document Type: Article
L3 - 10.1097/01.jom.0000141668.70006.52
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Stinson, Michael R.1
AU - Hildebrand, John A.2
AU - Benjamin, Kim C.3
AU - Bissinger, George A.4
AU - Ludwigsen, Daniel O.5
AU - Murphy, William J.6
AU - Kaduchak, Gregory A.7
AU - Matula, Thomas J.8
AU - Li Xu9
AU - Russell, Daniel A.5
AU - Shah, Amee P.10
AU - Tiemann, Christopher O.11
AU - Worcester, Peter F.12
AU - Wang, Lily13
AU - Roy, Kenneth P.14
AU - Mapp, Peter A.15
AU - Moore, Sue E.16
AU - Roy, Ronald A.17
AU - Murray, Todd W.17
AU - Daigle, Gilles A.18
T1 - Architectural Acoustics, Noise, Psychological and Physiological Acoustics, Speech Communication and Committee on Standards: Implementation of Classroom Acoustics I.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
J1 - Journal of the Acoustical Society of America
PY - 2004/10//
Y1 - 2004/10//
VL - 116
IS - 4
CP - 4
M3 - Article
SP - 2584
EP - 2636
SN - 00014966
AB - Presents abstracts of studies on architectural acoustics presented at the 148th meeting of the Acoustical Society of America in San Diego, California, November 15-19, 2004. "Forging improvements in classroom acoustical quality," by Angelo Bellomo; "Experiences implementing ANSI S12.60 in classrooms," by R. Kring Herbert and John Erdreich; "Source attenuating HVAC equipment--Just the facts," by Arthur Hallstrom; "Ten years of classroom acoustical design," by Angelo J. Campanella.
KW - Architectural acoustics
KW - Acoustical engineering -- Abstracts
KW - Sound -- Abstracts
KW - Education -- Abstracts
KW - Architecture -- Abstracts
N1 - Accession Number: 20839770; Authors: Stinson, Michael R. 1; Hildebrand, John A. 2; Benjamin, Kim C. 3; Bissinger, George A. 4; Ludwigsen, Daniel O. 5; Murphy, William J. 6; Kaduchak, Gregory A. 7; Matula, Thomas J. 8; Li Xu 9; Russell, Daniel A. 5; Shah, Amee P. 10; Tiemann, Christopher O. 11; Worcester, Peter F. 12; Wang, Lily 13; Roy, Kenneth P. 14; Mapp, Peter A. 15; Moore, Sue E. 16; Roy, Ronald A. 17; Murray, Todd W. 17; Daigle, Gilles A. 18; Affiliations: 1: National Research Council, Institute for Microstructural Science Montreal Road, Ottawa, Ontario K1A OR6, Canada; 2: Scripps Institute of Oceanography, University of California, San Diego, Mail Code A-005, La Jolla, California 92093-0205; 3: Naval Undersea Warfare Center, Newport, Rhode Island 02840; 4: Department of Physics, East Carolina University, Greenville, North Carolina 27858; 5: Science and Mathematics Departments, Kettering University, 1700 West Third Avenue, Flint, Michigan 48504-4898; 6: National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998; 7: Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, New Mexico 87545; 8: Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105-6698; 9: School of Hearing, Speech and Language Sciences, Ohio University, Athens, Ohio 45701; 10: School of Communication Sciences and Disorders, McGill University, 1266 Pine Avenue West, Montreal, Quebec, H3V 1C2 Canada; 11: Applied Research Laboratory, University of Texas at Austin, P.O. Box 8029, Austin, Texas 78731-8029; 12: Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0225; 13: Architectural Engineering, University of Nebraska Lincoln, Omaha, Nebraska 68182; 14: Armstrong World Industries, Innovation Center, 2500 Columbia Avenue, Lancaster, Pennsylvania 17604; 15: Mapp Associates, 5 Worthington Way, Colchester C03 4JZ United Kingdom; 16: National Marine Mammal Laboratory, 7600 Sand Point Way, NE, Seattle, Washington 98115; 17: Department of Aerospace and Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215; 18: Institute of Microstructural Science, National Research Council, Ottawa, Ontario K1A 0R6, Canada; Subject: Architectural acoustics; Subject: Acoustical engineering -- Abstracts; Subject: Sound -- Abstracts; Subject: Education -- Abstracts; Subject: Architecture -- Abstracts; Number of Pages: 53p; Record Type: Article
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DP - EBSCOhost
DB - asu
ER -
TY - JOUR
ID - 106625633
T1 - Product news.
AU - Morgan D
Y1 - 2004/10//2004 Oct
N1 - Accession Number: 106625633. Language: English. Entry Date: 20050506. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9306822.
KW - Bandages and Dressings
KW - Bandages and Dressings -- Economics
KW - Bandages and Dressings -- Trends
KW - Insurance, Health, Reimbursement
KW - United Kingdom
SP - 155
EP - 161
JO - Journal of Tissue Viability
JF - Journal of Tissue Viability
JA - J TISSUE VIABILITY
VL - 14
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0965-206X
AD - Consultant in Pharmaceutica Public Health, National Public Health Service for Wales, Hendy Road, Mold, Flintshire CH7 1PZ; david.morgan@nphs.wales.nhs.uk
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ER -
TY - JOUR
AU - Tollefson, L.
T1 - Developing New Regulatory Approaches to Antimicrobial Safety.
JO - Journal of Veterinary Medicine Series B
JF - Journal of Veterinary Medicine Series B
Y1 - 2004/10//
VL - 51
IS - 8/9
M3 - Article
SP - 415
EP - 418
PB - Wiley-Blackwell
SN - 09311793
AB - Resistance to antimicrobial agents is of concern to public health officials worldwide. In industrialized countries, a significant source of antimicrobial-resistant food-borne infections in humans is the acquisition of resistant bacteria originating from animals. The US Food and Drug Administration (FDA) is committed to resolving the public health impact arising from the use of antimicrobial drugs in food-producing animals. The FDAs goal is to ensure that significant human antimicrobial therapies are not compromised or lost while providing for the safe use of antimicrobials in food animals. Recently the FDA published a guidance document titled‘Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to their Microbiological Effects on Bacteria of Human Health Concern’ (). This document outlines a pathway drug sponsors can use to address concerns about antimicrobial resistance prior to approval of their drug. The process uses a qualitative risk assessment approach to assess the potential of the intended use of a product to develop resistance in bacteria that may harm humans. The level of risk determines the level of risk management that is required for the drug to be used. The Food and Drug Administration (FDA) always has the option of not approving a drug if the risk of a public health consequence is too high. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Medicine Series B is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - ANTIBIOTICS
KW - BACTERIAL diseases
KW - PUBLIC health
KW - ANTIBACTERIAL agents
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 14928093; Tollefson, L. 1; Email Address: ltollefs@cvm.fda.gov; Affiliation: 1: Center for Veterinary Medicine, Rockville, MD, USA; Source Info: Oct2004, Vol. 51 Issue 8/9, p415; Subject Term: ANTI-infective agents; Subject Term: ANTIBIOTICS; Subject Term: BACTERIAL diseases; Subject Term: PUBLIC health; Subject Term: ANTIBACTERIAL agents; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1439-0450.2004.00781.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Darnell, Miriam E.R.
AU - Subbarao, Kanta
AU - Feinstone, Stephen M.
AU - Taylor, Deborah R.
T1 - Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2004/10//
VL - 121
IS - 1
M3 - Article
SP - 85
EP - 91
SN - 01660934
AB - Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health Organization (WHO) recommends that manipulation of active viral cultures of SARS-CoV be performed in containment laboratories at biosafety level 3 (BSL3). The virus was inactivated by ultraviolet light (UV) at 254nm, heat treatment of 65°C or greater, alkaline (pH > 12) or acidic (pH < 3) conditions, formalin and glutaraldehyde treatments. We describe the kinetics of these efficient viral inactivation methods, which will allow research with SARS-CoV containing materials, that are rendered non-infectious, to be conducted at reduced safety levels. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SARS (Disease)
KW - ULTRAVIOLET radiation
KW - FORMALDEHYDE
KW - DYNAMICS
KW - Coronavirus
KW - SARS
KW - Tissue culture
KW - Virus inactivation
N1 - Accession Number: 14313698; Darnell, Miriam E.R. 1 Subbarao, Kanta 2 Feinstone, Stephen M. 1 Taylor, Deborah R.; Email Address: taylord@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, HFM448, Bethesda, MD 20892, USA 2: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Source Info: Oct2004, Vol. 121 Issue 1, p85; Subject Term: SARS (Disease); Subject Term: ULTRAVIOLET radiation; Subject Term: FORMALDEHYDE; Subject Term: DYNAMICS; Author-Supplied Keyword: Coronavirus; Author-Supplied Keyword: SARS; Author-Supplied Keyword: Tissue culture; Author-Supplied Keyword: Virus inactivation; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2004.06.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adamo, Joan E.
AU - Schröer, Jörg
AU - Shenk, Thomas
T1 - Human Cytomegalovirus TRS1 Protein Is Required for Efficient Assembly of DNA-Containing Capsids.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/10//
VL - 78
IS - 19
M3 - Article
SP - 10221
EP - 10229
SN - 0022538X
AB - The human cytomegalovirus tegument protein, pTRS1, appears to function at several discrete stages of the virus replication cycle. We previously demonstrated that pTRS1 acts during the late phase of infection to facilitate the production of infectious virions. We now have more precisely identified the late pTRS1 function by further study of a mutant virus lacking the TRS1 region, ADsubTRS1. We observed a significant reduction in the production of capsids, especially DNA-containing C-capsids, in mutant virus-infected cells. ADsubTRS1 exhibited normal cleavage of DNA concatemers, so the defect in C-capsid production must occur after DNA cleavage and before DNA is stably inserted into a capsid. Further, the normal virus-induced morphological reorganization of the nucleus did not occur after infection with the pTRS1-deficient mutant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOMEGALOVIRUSES
KW - PROTEINS
KW - VIRAL replication
KW - DNA
KW - HERPESVIRUSES
KW - CYTOMEGALOVIRUS diseases
KW - VIROLOGY
KW - MICROBIOLOGY
N1 - Accession Number: 14654238; Adamo, Joan E. 1 Schröer, Jörg 2 Shenk, Thomas 2; Email Address: tshenk@princeton.edu; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 2: Department of Molecular Biology, Princeton University, Princeton, New Jersey; Source Info: Oct2004, Vol. 78 Issue 19, p10221; Subject Term: CYTOMEGALOVIRUSES; Subject Term: PROTEINS; Subject Term: VIRAL replication; Subject Term: DNA; Subject Term: HERPESVIRUSES; Subject Term: CYTOMEGALOVIRUS diseases; Subject Term: VIROLOGY; Subject Term: MICROBIOLOGY; Number of Pages: 9p; Illustrations: 2 Color Photographs, 3 Black and White Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1128/JVI.78.19.10221-10229.2004
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DB - aph
ER -
TY - JOUR
AU - Gilmore, Robert D.
AU - Murphree Bacon, Rendi
AU - Sviat, Steven L.
AU - Petersen, Jeannine M.
AU - Bearden, Scott W.
T1 - Identification of Francisella tularensis genes encoding exported membrane-associated proteins using TnphoA mutagenesis of a genomic library
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2004/10//
VL - 37
IS - 4
M3 - Article
SP - 205
EP - 213
SN - 08824010
AB - Francisella tularensis, the causative agent of tularemia, is a highly infectious pathogen of humans and animals, yet little is known about the surface proteins of this organism that mediate mechanisms of pathogenicity. λTnphoA was used to generate random alkaline phosphatase gene fusions in a F. tularensis subsp. tularensis (strain Schu S4) genomic library to identify genes encoding exported extracytoplasmic proteins. Eleven genes encoding membrane-associated proteins were identified by this method and their respective signal peptides were characterized. Three of the genes encoded conserved ‘housekeeping’ enzymes, while the other eight genes were unique to F. tularensis, encoding proteins with molecular masses ranging from 11 to 78kDa as deduced from the amino acid sequences. Two genes putatively encoded lipoproteins based on the presence of characteristic signal peptidase II cleavage sites. Four selected proteins were found associated with outer membranes from Schu S4 and LVS strains by Western blotting. Indirect immunofluorescence of strain Schu S4 cells also showed evidence of protein localization to the outer membrane. Protein database searches produced significant alignments with proteins from other bacteria involved in carbohydrate transport, lipid metabolism, and cell envelope biogenesis, thereby providing clues for putative functions. These findings demonstrated that TnphoA mutagenesis can be used in conjunction with F. tularensis genome sequence data to provide a foundation for studies to identify and define cellular surface protein virulence factors of this pathogen. [Copyright &y& Elsevier]
AB - Copyright of Microbial Pathogenesis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tularemia
KW - Gram-negative bacterial diseases
KW - Alkaline phosphatase
KW - Amino acids
KW - Francisella tularensis
KW - Protein export
KW - Signal peptide
KW - TnphoA
N1 - Accession Number: 14583077; Gilmore, Robert D.; Email Address: rbg9@cdc.gov; Murphree Bacon, Rendi 1; Sviat, Steven L. 1; Petersen, Jeannine M. 2; Bearden, Scott W. 2; Affiliations: 1: Microbiology and Pathogenesis Laboratory, Bacterial Zoonoses Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, P.O. Box 2087, Rampart Rd, Foothills Campus, Fort Collins, CO 80522, USA; 2: Diagnostic and Reference Laboratory, Bacterial Zoonoses Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, P.O. Box 2087, Rampart Rd., Foothills Campus, Fort Collins, CO 80522, USA; Issue Info: Oct2004, Vol. 37 Issue 4, p205; Thesaurus Term: Tularemia; Thesaurus Term: Gram-negative bacterial diseases; Subject Term: Alkaline phosphatase; Subject Term: Amino acids; Author-Supplied Keyword: Francisella tularensis; Author-Supplied Keyword: Protein export; Author-Supplied Keyword: Signal peptide; Author-Supplied Keyword: TnphoA; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.micpath.2004.07.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Virmani, Ashraf
AU - Binienda, Zbigniew
T1 - Role of carnitine esters in brain neuropathology
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
Y1 - 2004/10//
VL - 25
IS - 5/6
M3 - Article
SP - 533
EP - 549
SN - 00982997
AB - l-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty acids have also been shown to be utilized by brain as an energy substrate. L-C also participates in the control of the mitochondrial acyl-CoA/CoA ratio, peroxisomal oxidation of fatty acids, and the production of ketone bodies. Due to their intrinsic interaction with the bioenergetic processes, they play an important role in diseases associated with metabolic compromise, especially mitochondrial-related disorders. A deficiency of carnitine is known to have major deleterious effects on the CNS. Several syndromes of secondary carnitine deficiency have been described that may result from defects in intermediary metabolism and alterations principally involving mitochondrial oxidative pathways. Mitochondrial superoxide formation resulting from disturbed electron transfer within the respiratory chain may affect the activities of respiratory chain complexes I, II, III, IV, and V and underlie some CNS pathologies. This mitochondrial dysfunction may be ameliorated by L-C and its esters. In addition to its metabolic role, L-C and its esters such as acetyl-l-carnitine (ALC) posses unique neuroprotective, neuromodulatory, and neurotrophic properties which may play an important role in counteracting various disease processes. Neural dysfunction and metabolic imbalances underlie many diseases, and the inclusion of metabolic modifiers may provide an alternative and early intervention approach, which may limit further developmental damage, cognitive loss, and improve long-term therapeutic outcomes. The neurophysiological and neuroprotective actions of L-C and ALC on cellular processes in the central and peripheral nervous system show such effects. Indeed, many studies have shown improvement in processes, such as memory and learning, and are discussed in this review. [Copyright &y& Elsevier]
AB - Copyright of Molecular Aspects of Medicine is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NERVOUS system -- Diseases
KW - VITAMIN B complex
KW - CARNITINE
KW - ORGANIC compounds
KW - Acetyl-l-carnitine
KW - Brain
KW - Cell
KW - FFA
KW - l-Carnitine
KW - Mitochondria
N1 - Accession Number: 14390761; Virmani, Ashraf 1; Email Address: ashraf.virmani@st-hs.it Binienda, Zbigniew 2; Affiliation: 1: Scientific Affairs, Sigma-tau HealthScience, Pomezia 00040, Italy 2: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Oct2004, Vol. 25 Issue 5/6, p533; Subject Term: NERVOUS system -- Diseases; Subject Term: VITAMIN B complex; Subject Term: CARNITINE; Subject Term: ORGANIC compounds; Author-Supplied Keyword: Acetyl-l-carnitine; Author-Supplied Keyword: Brain; Author-Supplied Keyword: Cell; Author-Supplied Keyword: FFA; Author-Supplied Keyword: l-Carnitine; Author-Supplied Keyword: Mitochondria; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.mam.2004.06.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Don
T1 - An IAQ Overview.
JO - Occupational Health & Safety
JF - Occupational Health & Safety
Y1 - 2004/10//
VL - 73
IS - 10
M3 - Article
SP - 66
EP - 96
SN - 03624064
AB - This article presents information on increasing ventilation in various industries. As structures become more airtight, an increasing level of gases, chemicals, and particulates merged with the ambient air. Heating, ventilating, and air-conditioning (HVAC) systems trapped and recirculated pollutants throughout structures. The U.S. Environmental Protection Agency consistently ranks indoor air pollution as one of the top five risks to public health. A lack of air exchange in modern housing is a primary reason these pollutants build to levels that affect health.
KW - Air quality
KW - Public health
KW - Ventilation
KW - Air pollution
KW - United States
KW - United States. Environmental Protection Agency
N1 - Accession Number: 14929583; Williams, Don 1; Email Address: donald.williams@mail.ihs.gov; Affiliations: 1: Environmental Health Officer with Indian Health Service, USPHS, Tucson, Ariz.; Issue Info: Oct2004, Vol. 73 Issue 10, p66; Thesaurus Term: Air quality; Thesaurus Term: Public health; Thesaurus Term: Ventilation; Thesaurus Term: Air pollution; Subject: United States ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106597368
T1 - An IAQ overview.
AU - Williams D
Y1 - 2004/10//
N1 - Accession Number: 106597368. Language: English. Entry Date: 20050325. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Consumer Health; USA. NLM UID: 7610574.
KW - Air Pollution, Indoor -- Prevention and Control
KW - Occupational Safety
KW - Ventilation
SP - 66
EP - 96
JO - Occupational Health & Safety
JF - Occupational Health & Safety
JA - OCCUP HEALTH SAF
VL - 73
IS - 10
CY - Chatsworth, California
PB - 1105 Media, Inc.
AB - Increasing ventilation is a fundamental method to reduce concentrations of several substances of concern.
SN - 0362-4064
AD - Environmental Health Officer, Indian Health Service, USPHS, Tucson, AZ; donald.williams@mail.ihs.gov
U2 - PMID: 15553419.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Feinsod, Matt
AU - Chambers, Wiley A.
T1 - Trials and tribulations: A primer on successfully navigating the waters of the Food and Drug Administration
JO - Ophthalmology
JF - Ophthalmology
Y1 - 2004/10//
VL - 111
IS - 10
M3 - Editorial
SP - 1801
EP - 1806
SN - 01616420
AB - Conducting clinical trials in a regulated environment constitutes unfamiliar territory for most physicians. There exists no formal training in this subject, so many clinicians lack even a basic understanding of the procedures required by the Federal Food, Drug, and Cosmetic Act and their implications vis-à-vis clinical practice. The authors distill drug regulation to relevant applications and elucidate the rationale and procedures for submitting an Investigational New Drug application by providing a user-friendly road map of the process. [Copyright &y& Elsevier]
AB - Copyright of Ophthalmology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - MEDICAL personnel
KW - DRUG delivery systems
KW - MEDICAL research
N1 - Accession Number: 14579293; Feinsod, Matt 1 Chambers, Wiley A. 1; Affiliation: 1: United States Food and Drug Administration, Rockville, Maryland, USA; Source Info: Oct2004, Vol. 111 Issue 10, p1801; Subject Term: CLINICAL trials; Subject Term: MEDICAL personnel; Subject Term: DRUG delivery systems; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Editorial
L3 - 10.1016/j.ophtha.2004.05.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holman, Robert C.
AU - Curns, Aaron T.
AU - Cheek, James E.
AU - Bresee, Joseph S.
AU - Singleton, Rosalyn J.
AU - Carver, Karen
AU - Anderson, Larry J.
T1 - Respiratory Syncytial Virus Hospitalizations Among American Indian and Alaska Native Infants and the General United States Infant Population.
JO - Pediatrics
JF - Pediatrics
Y1 - 2004/10//
VL - 114
IS - 4
M3 - Article
SP - e437
EP - e444
PB - American Academy of Pediatrics
SN - 00314005
AB - ABSTRACT. Objective. To determine the burden of respiratory syncytial virus (RSV) disease among American Indian (AI) and Alaska Native (AN) infants, by examining RSV-associated hospitalizations. Methods. Infant hospitalizations from 1997 through 2001 with RSV listed as a diagnosis were selected by using Indian Health Service/tribal hospital discharge data for AIs/ANs and National Hospital Discharge Survey data for the general US population. Results. In 2000-2001, RSV disease was listed as a diagnosis for 14.4% of all AI/AN infant hospitalizations, with bronchiolitis attributable to RSV infection (12.2%) being among the top 5 listed diagnoses. The rate of RSV-specific hospitalizations was 34.4 hospitalizations per 1000 infants for AI/AN infants and 27.4 hospitalizations per 1000 births for the general US infant population. The hospitalization rates for AI/AN infants living in the Alaska and Southwest regions (70.9 and 48.2 hospitalizations per 1000 infants, respectively) were much higher than the overall rate for US infants. Conclusions. RSV infection is one of the leading causes of hospitalization among all infants in the United States, and AI/AN infants living in the Southwest and Alaska regions are at especially high risk for hospitalizations associated with RSV infection. Development of vaccines, antiviral agents, and other strategies to prevent RSV disease could yield substantial public health benefits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - NATIVE Americans
KW - DISEASES
KW - INFANT diseases
KW - PEDIATRICS
KW - VACCINATION of children
KW - Alaska Native
KW - American Indian
KW - bronchiolitis
KW - epidemiology
KW - hospitalizations
KW - infants
KW - pneumonia
KW - respiratory disease
KW - respiratory syncytial virus
KW - RSV
KW - United States
N1 - Accession Number: 14488670; Holman, Robert C. 1 Curns, Aaron T. 1 Cheek, James E. 2 Bresee, Joseph S. 3 Singleton, Rosalyn J. 4 Carver, Karen 5 Anderson, Larry J. 3; Affiliation: 1: Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Epidemiology Program, Office of Public Health, Indian Health Service Headquarters, Albuquerque, New Mexico 3: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 4: Alaska Native Tribal Health Consortium and Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 5: Office of Public Health, Indian Health Service Headquarters, Rockville, Maryland; Source Info: Oct2004, Vol. 114 Issue 4, pe437; Subject Term: RESPIRATORY syncytial virus; Subject Term: NATIVE Americans; Subject Term: DISEASES; Subject Term: INFANT diseases; Subject Term: PEDIATRICS; Subject Term: VACCINATION of children; Author-Supplied Keyword: Alaska Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: bronchiolitis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hospitalizations; Author-Supplied Keyword: infants; Author-Supplied Keyword: pneumonia; Author-Supplied Keyword: respiratory disease; Author-Supplied Keyword: respiratory syncytial virus; Author-Supplied Keyword: RSV; Author-Supplied Keyword: United States; Number of Pages: 8p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1542/peds.2004-0049
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14488670&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Robert M.
AU - Bena, James F.
AU - Stayner, Leslie T.
AU - Smith, Randall J.
AU - Gibb, Herman J.
AU - Lees, Peter S. J.
T1 - Hexavalent Chromium and Lung Cancer in the Chromate Industry: A Quantitative Risk Assessment.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2004/10//
VL - 24
IS - 5
M3 - Article
SP - 1099
EP - 1108
PB - Wiley-Blackwell
SN - 02724332
AB - The purpose of this investigation was to estimate excess lifetime risk of lung cancer death resulting from occupational exposure to hexavalent-chromium-containing dusts and mists. The mortality experience in a previously studied cohort of 2,357 chromate chemical production workers with 122 lung cancer deaths was analyzed with Poisson regression methods. Extensive records of air samples evaluated for water-soluble total hexavalent chromium were available for the entire employment history of this cohort. Six different models of exposure-response for hexavalent chromium were evaluated by comparing deviances and inspection of cubic splines. Smoking (pack-years) imputed from cigarette use at hire was included in the model. Lifetime risks of lung cancer death from exposure to hexavalent chromium (assuming up to 45 years of exposure) were estimated using an actuarial calculation that accounts for competing causes of death. A linear relative rate model gave a good and readily interpretable fit to the data. The estimated rate ratio for 1 mg/m3-yr of cumulative exposure to hexavalent chromium (as CrO3), with a lag of five years, wasRR= 2.44 (95% CI= 1.54–3.83). The excess lifetime risk of lung cancer death from exposure to hexavalent chromium at the current OSHA permissible exposure limit (PEL) (0.10 mg/m3) was estimated to be 255 per 1,000 (95% CI: 109–416). This estimate is comparable to previous estimates by U.S. EPA, California EPA, and OSHA using different occupational data. Our analysis predicts that current occupational standards for hexavalent chromium permit a lifetime excess risk of dying of lung cancer that exceeds 1 in 10, which is consistent with previous risk assessments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hexavalent chromium
KW - Risk assessment
KW - Health risk assessment
KW - Lungs -- Cancer
KW - Cancer
KW - Regression analysis
KW - Excess lifetime risk
KW - hexavalent chromium exposure-response
KW - race interaction
N1 - Accession Number: 15022563; Park, Robert M. 1; Email Address: rhp9@cdc.gov; Bena, James F. 1; Stayner, Leslie T. 1; Smith, Randall J. 1; Gibb, Herman J. 2; Lees, Peter S. J. 2; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-15, Cincinnati, OH, USA; 2: The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD; Issue Info: Oct2004, Vol. 24 Issue 5, p1099; Thesaurus Term: Hexavalent chromium; Thesaurus Term: Risk assessment; Thesaurus Term: Health risk assessment; Subject Term: Lungs -- Cancer; Subject Term: Cancer; Subject Term: Regression analysis; Author-Supplied Keyword: Excess lifetime risk; Author-Supplied Keyword: hexavalent chromium exposure-response; Author-Supplied Keyword: race interaction; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1111/j.0272-4332.2004.00512.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15022563&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jacobs, Abigail
AU - Jacobson-Kram, David
T1 - Human Carcinogenic Risk Evaluation, Part III: Assessing Cancer Hazard and Risk in Human Drug Development.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/10//
VL - 81
IS - 2
M3 - Article
SP - 260
EP - 262
PB - Oxford University Press / USA
SN - 10966080
AB - Assessing cancer risk for human pharmaceuticals is important because drugs are taken at pharmacologically active doses and often on a chronic basis. Epidemiologic studies on patient populations have limited value because of the long latency period for most cancers and because these studies lack sensitivity. The Center for Drug Evaluation and Research (CDER) of the U.S. Food and Drug Administration relies on short-term surrogate assays (genetic toxicology studies) to assess risk to patients involved in clinical trials and on rodent carcinogenicity studies to assess cancer risk for drug approval. Unlike some other agencies that typically perform quantitative risk assessments on chemical pollutants or pesticide products, CDER does not perform such quantitative extrapolations. Rather, the evaluation of risk is the result of an integrated assessment of what is known about the drug, and risk is considered in the context of the clinical benefit. Mode of action of carcinogenesis and thresholds for effects are important considerations. The results of carcinogenicity studies of approved products are published in the drug labeling and individual clinicians balance risk and benefit in making prescribing decisions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Carcinogens
KW - Genetic toxicology
KW - Epidemiology
KW - Drug development
KW - United States
KW - carcinogenicity
KW - drug development
KW - risk
KW - United States. Food & Drug Administration
N1 - Accession Number: 20605653; Jacobs, Abigail 1; Email Address: abigail.jacobs@fdahhs.gov; Jacobson-Kram, David 1; Affiliations: 1: U.S. Food and Drug Administration, Rockville, Maryland; Issue Info: Oct2004, Vol. 81 Issue 2, p260; Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogens; Thesaurus Term: Genetic toxicology; Thesaurus Term: Epidemiology; Subject Term: Drug development; Subject: United States; Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: drug development; Author-Supplied Keyword: risk ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1093/toxsci/kfh167
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20605653&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buehler, Paul W.
AU - Alayash, Abdu I.
T1 - Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems.
JO - Transfusion
JF - Transfusion
Y1 - 2004/10//
VL - 44
IS - 10
M3 - Article
SP - 1516
EP - 1530
PB - Wiley-Blackwell
SN - 00411132
AB - Several hemoglobin-based oxygen carriers (HBOCs) have been developed with a rationale focused on exploiting one or more physicochemical properties (e.g., oxygen affinity, molecular weight, viscosity, and colloid osmotic pressure) resulting from the chemical or recombinant modification of hemoglobin (Hb). Several chemically modified Hbs have reached late stages of clinical evaluation in the United States and Canada. These Hbs, in general, demonstrated mixed preclinical safety and efficacy, and reasonable safety in Phase I trials. However, as clinical development shifted into later stages, an undesirable safety and efficacy profile became clear in patient populations studied, and as a result some products were withdrawn from further clinical pursuit. Several questions still remain unanswered regarding the safety of Hb products for their proposed clinical indication(s). For example, 1) were preclinical studies predictive of clinical outcome? And, 2) were the most appropriate preclinical studies performed to predict clinical outcome?The primary objectives of this analysis are to explore prelinical safety issues associated with HBOCs and provide an overview of the in-vitro and in-vivo models employed. The methods for obtaining data to serve as a basis for discussion are compiled from a literature-based survey of safety and efficacy derived from biochemical, cellular, and whole animal assessment of HBOCs. Results from this overview of a vast body of published data may provide a means for identifying critical preclinical safety issues, which may ultimately lead to identification of potential limitations in the effective clinical use of certain HBOCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - BLOOD proteins
KW - BLOOD -- Pigments
KW - ERYTHROCYTES
KW - HEMOPROTEINS
KW - BLOOD transfusion
N1 - Accession Number: 14454523; Buehler, Paul W. 1,2 Alayash, Abdu I. 1,2; Email Address: alayash@cber.fda.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology 2: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland; Source Info: Oct2004, Vol. 44 Issue 10, p1516; Subject Term: HEMOGLOBIN; Subject Term: BLOOD proteins; Subject Term: BLOOD -- Pigments; Subject Term: ERYTHROCYTES; Subject Term: HEMOPROTEINS; Subject Term: BLOOD transfusion; Number of Pages: 15p; Document Type: Article
L3 - 10.1111/j.1537-2995.2004.04081.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14454523&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Babu, U.
AU - Dalloul, R.A.
AU - Okamura, M.
AU - Lillehoj, H.S.
AU - Xie, H.
AU - Raybourne, R.B.
AU - Gaines, D.
AU - Heckert, R.A.
T1 - Salmonella enteritidis clearance and immune responses in chickens following Salmonella vaccination and challenge
JO - Veterinary Immunology & Immunopathology
JF - Veterinary Immunology & Immunopathology
Y1 - 2004/10//
VL - 101
IS - 3/4
M3 - Article
SP - 251
EP - 257
SN - 01652427
AB - Our previous work showed that the cell-mediated immunity (CMI) was enhanced by live Salmonella vaccine (LV). The objective of this study was to evaluate the impact of live and killed Salmonella vaccines on Salmonella enteritidis (SE) clearance and to determine if the clearance was mediated by cell-mediated and/or humoral immunity. Chickens were first immunized at 2 weeks of age followed by a booster dose at 4 weeks, challenged with live SE 2 weeks later (6-week-old) and tested for CMI, antibody response and SE clearance 1-week post SE-challenge (7-week-old). Spleen cell proliferation induced by SE-flagella and Concanavalin A (Con A) were significantly higher and SE shedding was significantly lower in the LV group. The splenic CD3 population was significantly lower and B cells were higher in the control group compared to all the SE-challenged groups (with and without vaccination). Serum antibody to SE-flagella and envelope were significantly higher in the KV group compared to all the other groups. These results suggest that LV protects against SE infection, probably by enhancing the CMI. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Immunology & Immunopathology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - IMMUNE response
KW - CHICKENS
KW - IMMUNITY
KW - cell-mediated immunity (CMI)
KW - Chicken
KW - days post immunization (DPI)
KW - delayed type hypersensitivity (DTH)
KW - Flagella
KW - Hank’s balanced salt solution (HBSS)
KW - hour(s) (h)
KW - killed vaccine (KV)
KW - live vaccine (LV)
KW - Lymphocyte proliferation
KW - minute (min)
KW - mononuclear cells (MNC)
KW - room temperature (RT)
KW - Salmonella enteritidis
KW - Salmonella enteritidis (SE)
KW - seconds (s)
KW - Vaccine
N1 - Accession Number: 14312556; Babu, U. 1; Email Address: usb@cfsan.fda.gov Dalloul, R.A. 2,3 Okamura, M. 2 Lillehoj, H.S. 2 Xie, H. 3 Raybourne, R.B. 1 Gaines, D. 1 Heckert, R.A. 3; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS-326, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, ARS, USDA, Building 1040 BARC-East, Beltsville, MD 20705, USA 3: Virginia–Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA; Source Info: Oct2004, Vol. 101 Issue 3/4, p251; Subject Term: SALMONELLA enteritidis; Subject Term: IMMUNE response; Subject Term: CHICKENS; Subject Term: IMMUNITY; Author-Supplied Keyword: cell-mediated immunity (CMI); Author-Supplied Keyword: Chicken; Author-Supplied Keyword: days post immunization (DPI); Author-Supplied Keyword: delayed type hypersensitivity (DTH); Author-Supplied Keyword: Flagella; Author-Supplied Keyword: Hank’s balanced salt solution (HBSS); Author-Supplied Keyword: hour(s) (h); Author-Supplied Keyword: killed vaccine (KV); Author-Supplied Keyword: live vaccine (LV); Author-Supplied Keyword: Lymphocyte proliferation; Author-Supplied Keyword: minute (min); Author-Supplied Keyword: mononuclear cells (MNC); Author-Supplied Keyword: room temperature (RT); Author-Supplied Keyword: Salmonella enteritidis; Author-Supplied Keyword: Salmonella enteritidis (SE); Author-Supplied Keyword: seconds (s); Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vetimm.2004.05.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14312556&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-18967-003
AN - 2004-18967-003
AU - Springer, J. Fred
AU - Sale, Elizabeth
AU - Hermann, Jack
AU - Sambrano, Soledad
AU - Kasim, Rafa
AU - Nistler, Mary
T1 - Characteristics of Effective Substance Abuse Prevention Programs for High-Risk Youth.
JF - The Journal of Primary Prevention
JO - The Journal of Primary Prevention
JA - J Prim Prev
Y1 - 2004/10//
VL - 25
IS - 2
SP - 171
EP - 194
CY - Germany
PB - Springer
SN - 0278-095X
SN - 1573-6547
AD - Springer, J. Fred, EMT Associates, Inc., 771 Oak Avenue Parkway, Folsom, CA, US, 95630
N1 - Accession Number: 2004-18967-003. Partial author list: First Author & Affiliation: Springer, J. Fred; EMT Associates, Inc., Folsom, CA, US. Release Date: 20050314. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Drug Abuse Prevention; Drug Rehabilitation; Program Evaluation. Minor Descriptor: School Based Intervention. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 24. Issue Publication Date: Oct, 2004.
AB - The last two decades have witnessed a rapid development of substance abuse prevention programs. Most efforts to evaluate these programs have been limited to single program studies, and nearly all studies involving multiple drug prevention programs have involved school-based programs for general youth populations. In 1995, the Center for Substance Abuse Prevention (CSAP), with the Substance Abuse and Mental Health Administration (SAMHSA), funded the CSAP National Cross-site Evaluation of High Risk Youth Programs, a five-year, multi-site evaluation study involving 46 programs and over 10,500 youth at high risk for substance use (CSAP, 2002(a)). This article reports findings from this evaluation, focusing on program characteristics that help explain reductions in 30-day substance use among program participants. Programs found to be most effective in reducing substance use were those that offered strong behavioral life skills development content, emphasized team-building and interpersonal delivery methods, emphasized introspective learning approaches focusing on self-reflection, were based upon a clearly articulated and coherent program theory, and provided intense contact with youth. Programs utilizing these positive program components produced consistent and lasting reductions in substance use. These findings provide a solid basis for the adoption of positive program characteristics in the development of future prevention programming for high-risk youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse prevention program
KW - school based intervention
KW - program evaluation
KW - life skills
KW - high risk youth
KW - 2004
KW - At Risk Populations
KW - Drug Abuse Prevention
KW - Drug Rehabilitation
KW - Program Evaluation
KW - School Based Intervention
KW - 2004
DO - 10.1023/B:JOPP.0000042388.63695.3f
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18967-003&site=ehost-live&scope=site
UR - fred@emt.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20575-004
AN - 2004-20575-004
AU - Dennis, Michael
AU - Godley, Susan H.
AU - Diamond, Guy
AU - Tims, Frank M.
AU - Babor, Thomas
AU - Donaldson, Jean
AU - Liddle, Howard
AU - Titus, Janet C.
AU - Kaminer, Yifrah
AU - Webb, Charles
AU - Hamilton, Nancy
AU - Funk, Rod
T1 - The Cannabis Youth Treatment (CYT) Study: Main findings from two randomized trials.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2004/10//
VL - 27
IS - 3
SP - 197
EP - 213
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Dennis, Michael, Chestnut Health Systems, 720 West Chestnut, Bloomington, IL, US, 61701
N1 - Accession Number: 2004-20575-004. PMID: 15501373 Partial author list: First Author & Affiliation: Dennis, Michael; Chestnut Health Systems, Bloomington, IL, US. Release Date: 20041220. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cannabis; Costs and Cost Analysis; Drug Rehabilitation; Health Care Costs; Treatment Outcomes. Minor Descriptor: Cognitive Behavior Therapy; Drug Abstinence; Drug Abuse; Outpatient Treatment. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Global Appraisal of Individual Needs. Methodology: Empirical Study; Followup Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Oct, 2004.
AB - This article presents the main outcome findings from two inter-related randomized trials conducted at four sites to evaluate the effectiveness and cost-effectiveness of five short-term outpatient interventions for adolescents with cannabis use disorders. Trial 1 compared five sessions of Motivational Enhancement Therapy plus Cognitive Behavioral Therapy (MET/CBT) with a 12-session regimen of MET and CBT (MET/CBT 12) and another that included family education and therapy components (Family Support Network [FSN]). Trial II compared the five-session MET/CBT with the Adolescent Community Reinforcement Approach (ACRA) and Multidimensional Family Therapy (MDFT). The 600 cannabis users were predominately white males, aged 15-16. All five CYT interventions demonstrated significant pre-post treatment improvements during the 12 months after random assignment to a treatment intervention in the two main outcomes: days of abstinence and the percent of adolescents in recovery (no use or abuse/dependence problems and living in the community). Overall, the clinical outcomes were very similar across sites and conditions; however, after controlling for initial severity, the most cost-effective interventions were MET/CBT5 and MET/CBT 12 in Trial 1 and ACRA and MET/CBT5 in Trial 2. It is possible that the similar results occurred because outcomes were driven more by general factors beyond the treatment approaches tested in this study; or because of shared, general helping factors across therapies that helped these teens attend to and decrease their connection to cannabis and alcohol. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Cannabis Youth Treatment
KW - outcome findings
KW - randomized trials
KW - adolescent drug treatment
KW - cost effectiveness
KW - intervention
KW - motivational enhancement therapy
KW - cognitive behavior therapy
KW - cannabis use
KW - 2004
KW - Cannabis
KW - Costs and Cost Analysis
KW - Drug Rehabilitation
KW - Health Care Costs
KW - Treatment Outcomes
KW - Cognitive Behavior Therapy
KW - Drug Abstinence
KW - Drug Abuse
KW - Outpatient Treatment
KW - 2004
DO - 10.1016/j.jsat.2003.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20575-004&site=ehost-live&scope=site
UR - mdennis@chestnut.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19212-002
AN - 2004-19212-002
AU - Miller, Jacqueline W.
AU - Gfroerer, Joseph C.
AU - Brewer, Robert D.
AU - Naimi, Timothy S.
AU - Mokdad, Ali
AU - Giles, Wayne H.
T1 - Prevalence of Adult Binge Drinking: A Comparison of Two National Surveys.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2004/10//
VL - 27
IS - 3
SP - 197
EP - 204
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Miller, Jacqueline W., National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K-67, Atlanta, GA, US, 30341
N1 - Accession Number: 2004-19212-002. PMID: 15450631 Partial author list: First Author & Affiliation: Miller, Jacqueline W.; Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, National Centers for Chronic Disease Prevention and Health Promotion, Atlanta, GA, US. Release Date: 20050118. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Alcohol Drinking Patterns; Epidemiology; Methodology; Surveys. Minor Descriptor: Binge Drinking; Drug Abuse Prevention; Mortality Rate. Classification: Health Psychology Testing (2226); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2004.
AB - Background: Binge drinking (defined as five or more drinks on an occasion) causes approximately half of the estimated 85,000 alcohol-related deaths in the United States each year. The Behavioral Risk Factor Surveillance System (BRFSS), a telephone survey, and the National Survey on Drug Use and Health (NSDUH), an in-person survey, provide population-based estimates of binge drinking. Evaluating the concordance of binge drinking estimates from the BRFSS and the NSDUH is important for surveillance and for planning prevention programs. Methods: In 2003, combined data on binge drinking for 1999 and 2001 from the BRFSS (n=355,371) and the NSDUH (n=87,145) were analyzed for respondents aged ≥18 years. Results: National binge drinking estimates were 14.7% (95% confidence interval [CI]=14.5-15.2) for BRFSS and 21.6% (CI=21.2-22.0) for NSDUH. Although there was good correlation between state-specific binge drinking estimates from the two surveys (Pearson's r=0.82), the BRFSS state estimates were significantly lower (p <0.05) than the NSDUH estimates in 46 states and the District of Columbia. The demographic characteristics of binge drinkers and the wording of the binge question were similar in the two surveys. However, in 1999, NSDUH changed from paper interviews to computer-administered interviews, and incorporated an internal validity check with feedback questions to resolve inconsistent responses. Conclusions: Estimates of binge drinking from the NSDUH were consistently higher than those from the BRFSS, probably due to differences in survey methodology. Continued efforts to improve binge drinking surveillance are important for preventing this public health problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - binge drinking
KW - alcohol related deaths
KW - prevention programs planning
KW - 2004
KW - Alcohol Abuse
KW - Alcohol Drinking Patterns
KW - Epidemiology
KW - Methodology
KW - Surveys
KW - Binge Drinking
KW - Drug Abuse Prevention
KW - Mortality Rate
KW - 2004
DO - 10.1016/j.amepre.2004.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19212-002&site=ehost-live&scope=site
UR - ORCID: 0000-0001-9849-4413
UR -
UR - JMiller5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20213-001
AN - 2004-20213-001
AU - Davis, Maryann
AU - Banks, Steven
AU - Fisher, William
AU - Grudzinskas, Albert
T1 - Longitudinal Patterns of Offending During the Transition to Adulthood in Youth From the Mental Health System.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2004/10//Oct-Dec, 2004
VL - 31
IS - 4
SP - 351
EP - 366
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Davis, Maryann, Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Ave., Worcester, MA, US, 01655
N1 - Accession Number: 2004-20213-001. PMID: 15602138 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Davis, Maryann; Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Springer. Release Date: 20041206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Crime; Criminal Justice; Legal Arrest; Mental Health Services. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Oct-Dec, 2004.
AB - Arrest rates among the population of youth who have been served in child mental health systems are known to be high during adolescence and young adulthood, but individual longitudinal patterns have not been examined. The present study used developmental trajectory modeling, a contemporary method used widely in criminology, to examine clusters of individual criminal justice involvement patterns at ages 8 through 25, from database records of 131 individuals in public adolescent mental health services. Three groups of particular concern emerged: one with increasingly high offense rates and two with moderate to high violent offense rates that did not desist. Offense patterns in these groups indicate that early intervention should occur before age 15. Some risk factors were identified. Peak offending for most groups occurred between ages 18 and 20. Implications of these findings for mental health services during the transition to adulthood are offered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - offense rates
KW - mental health services
KW - criminal justice
KW - arrest rates
KW - transition to adulthood
KW - 2004
KW - Crime
KW - Criminal Justice
KW - Legal Arrest
KW - Mental Health Services
KW - 2004
DO - 10.1007/BF02287689
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20213-001&site=ehost-live&scope=site
UR - maryann.davis@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20213-003
AN - 2004-20213-003
AU - Cook, Judith A.
AU - Heflinger, Craig Anne
AU - Hoven, Christina W.
AU - Kelleher, Kelly J.
AU - Mulkern, Virginia
AU - Paulson, Robert I.
AU - Stein-Seroussi, Al
AU - Fitzgibbon, Genevieve
AU - Burke-Miller, Jane
AU - Williams, Melissa
AU - Kim, Jong-Bae
T1 - A Multi-site Study of Medicaid-funded Managed Care Versus Fee-for-Service Plans' Effects on Mental Health Service Utilization of Children With Severe Emotional Disturbance.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2004/10//Oct-Dec, 2004
VL - 31
IS - 4
SP - 384
EP - 402
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Cook, Judith A., Department of Psychiatry, Center on Mental Health Services Research and Policy, University of Illinois, 104 S Michigan Ave, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2004-20213-003. PMID: 15602140 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Cook, Judith A.; Department of Psychiatry, Center on Mental Health Services Research and Policy, University of Illinois, Chicago, IL, US. Other Publishers: Springer. Release Date: 20041206. Correction Date: 20121022. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Disturbances; Health Care Utilization; Managed Care; Medicaid; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Short-Form Health Survey; Child Behavior Checklist; Caregiver Strain Questionnaire DOI: 10.1037/t13809-000; Columbia Impairment Scale DOI: 10.1037/t06724-000. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Other Internet. References Available: Y. Page Count: 19. Issue Publication Date: Oct-Dec, 2004.
AB - Although Medicaid-funded managed care arrangements are commonly used in the delivery of mental health and substance abuse services to low-income children and youth, little is known about the effectiveness of such efforts. This article examines differences in mental health services utilization between children and youth with severe emotional disturbance covered by Medicaid-funded managed care behavioral health plans and those covered by fee-for-service plans. Data are from a federally funded multi-site study. In multivariate analyses controlling for child and caregiver demographic and clinical factors, enrollment in a managed care behavioral health plan was associated with lower inpatient/residential, psychiatric medication, and nontraditional services utilization. No difference was found in outpatient services utilization. Medicaid-funded managed care behavioral health plans appear to reduce use of some types of mental health services, but it is important to address the question of whether low-income children's enrollment in such programs deprives them of needed services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - managed care
KW - fee for service plans
KW - mental health services utilization
KW - substance abuse services
KW - emotional disturbance
KW - low income children
KW - 2004
KW - Emotional Disturbances
KW - Health Care Utilization
KW - Managed Care
KW - Medicaid
KW - Mental Health Services
KW - 2004
DO - 10.1007/BF02287691
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20213-003&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19822-011
AN - 2004-19822-011
AU - Monk, Christopher S.
AU - Nelson, Eric E.
AU - Woldehawariat, Girma
AU - Montgomery, Lee Anne
AU - Zarahn, Eric
AU - McClure, Erin B.
AU - Guyer, Amanda E.
AU - Leibenluft, Ellen
AU - Charney, Dennis S.
AU - Ernst, Monique
AU - Pine, Daniel S.
T1 - Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans.
JF - Biological Psychiatry
JO - Biological Psychiatry
JA - Biol Psychiatry
Y1 - 2004/10//
VL - 56
IS - 8
SP - 607
EP - 610
CY - Netherlands
PB - Elsevier Science
SN - 0006-3223
AD - Monk, Christopher S., 15K North Drive, Room 204, Bethesda, MD, US, 20892-2670
N1 - Accession Number: 2004-19822-011. PMID: 15476691 Partial author list: First Author & Affiliation: Monk, Christopher S.; National Institute of Mental Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20041108. Correction Date: 20121119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Anxiety Disorders; Attention; Neural Plasticity; Threat. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Wechsler Abbreviated Scale of Intelligence DOI: 10.1037/t15170-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Oct, 2004.
AB - Biased attention to threat represents a key feature of anxiety disorders. This bias is altered by therapeutic or stressful experiences, suggesting that the bias is plastic. Charting on-line behavioral and neurophysiological changes in attention bias may generate insights on the nature of such plasticity. We used an attention-orientation task with threat cues to examine how healthy individuals alter their response over time to such cues. In Experiments 1 through 3, we established that healthy individuals demonstrate an increased attention bias away from threat over time. For Experiment 3, we used functional magnetic resonance imaging to determine the neural bases for this phenomenon. Gradually increasing attention bias away from threat is associated with increased activation in the occipitotemporal cortex. Examination of plasticity of attention bias with individuals at risk for anxiety disorders may reveal how threatening stimuli come to be categorized differently in this population over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - plasticity
KW - attention bias
KW - threat
KW - anxiety disorders
KW - 2004
KW - Anxiety Disorders
KW - Attention
KW - Neural Plasticity
KW - Threat
KW - 2004
DO - 10.1016/j.biopsych.2004.07.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19822-011&site=ehost-live&scope=site
UR - ORCID: 0000-0002-3376-2453
UR -
UR - christopher.monk@nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20154-008
AN - 2004-20154-008
AU - McAuley, William J.
AU - Spector, William D.
AU - Van Nostrand, Joan
AU - Shaffer, Tom
T1 - The Influence of Rural Location on Utilization of Formal Home Care: The Role of Medicaid.
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2004/10//
VL - 44
IS - 5
SP - 655
EP - 664
CY - US
PB - Gerontological Society of America
SN - 0016-9013
SN - 1758-5341
AD - McAuley, William J., Department of Health Administration and Policy, UNC, Colvard Building, 9201 University City Blvd., Charlotte, NC, US, 28223
N1 - Accession Number: 2004-20154-008. PMID: 15498841 Partial author list: First Author & Affiliation: McAuley, William J.; Department of Health Administration and Policy, University of North Carolina, Charlotte, NC, US. Other Publishers: Oxford University Press. Release Date: 20050531. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Home Care; Medicaid; Rural Environments; Urban Environments. Classification: Home Care & Hospice (3375). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2004.
AB - Purpose: This research examines the impact of rural-urban residence on formal home-care utilization among older people and determines whether and how Medicaid coverage influences the association between rural-urban location and risk of formal home-care use. Design and Methods: We combined data from the 1998 consolidated file of the Medical Expenditure Panel Survey Household Component with data from the Area Resource File to generate the analytical data set. We established two measures of formal home-care utilization: home care reimbursed through any source, and Medicare-reimbursed home health care. Our measures of rural-urban residence included metropolitan counties, nonmetropolitan counties having towns of at least 10,000 people, and nonmetropolitan counties with no towns of 10,000 people. We used logistic regression analyses to examine main effects and interaction effects of Medicaid coverage and residence on the two types of formal home care under controls for person-level characteristics and state fixed effects. Results: The unadjusted logistic analyses demonstrate that older people who reside in the most rural counties (nonmetropolitan counties having no town of 10,000) are significantly more likely than metropolitan residents to use any formal home care and Medicare home health care. The fully adjusted logistic analysis results point to an interplay between residential status and Medicaid coverage with regard to formal home-care use. In comparison with metropolitan residents covered by Medicaid, the adjusted relative risk of any formal home-care use is significantly higher for Medicaid enrollees residing in nonmetropolitan counties having no town of 10,000 people. Use of Medicare home health care is significantly greater for residents of the most rural counties, irrespective of their Medicaid coverage, as well as Medicaid-covered residents of nonmetropolitan counties having a town of at least 10,000 people. Implications: In nonmetropolitan areas, Medicaid may be an important mechanism for linking older individuals with formal home care, especially Medicare home health care, and with the services that generate formal home care. Formal home care, including Medicare home health care, may substitute for less available forms of care in the most rural of nonmetropolitan areas. Therefore, policies that limit access to formal home care could lead to increased service-related vulnerabilities among older rural residents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rural location
KW - health care utilization
KW - formal home care
KW - medicaid
KW - urban location
KW - 2004
KW - Health Care Utilization
KW - Home Care
KW - Medicaid
KW - Rural Environments
KW - Urban Environments
KW - 2004
DO - 10.1093/geront/44.5.655
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20154-008&site=ehost-live&scope=site
UR - wjmcaule@uncc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18981-007
AN - 2004-18981-007
AU - Benjamins, Maureen R.
AU - Kirby, James B.
AU - Bond Huie, Stephanie A.
T1 - County characteristics and racial and ethnic disparities in the use of preventive services.
JF - Preventive Medicine: An International Journal Devoted to Practice and Theory
JO - Preventive Medicine: An International Journal Devoted to Practice and Theory
JA - Prev Med
Y1 - 2004/10//
VL - 39
IS - 4
SP - 704
EP - 712
CY - Netherlands
PB - Elsevier Science
SN - 0091-7435
AD - Benjamins, Maureen R., Population Research Center, University of Texas, 1 University Station G1800, Austinx, TX, US, 78712
N1 - Accession Number: 2004-18981-007. PMID: 15351536 Other Journal Title: Preventative Medicine: An International Journal Devoted to Practice & Theory. Partial author list: First Author & Affiliation: Benjamins, Maureen R.; Population Research Center, University of Texas, Austin, TX, US. Release Date: 20050321. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Care Utilization; Prevention; Racial and Ethnic Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 2004.
AB - Background: Studies examining predictors of preventive service utilization generally focus on individual characteristics and ignore the role of contextual variables. To help address this gap in the literature, the present study investigates whether county-level characteristics, such as racial and ethnic composition, are associated with the use of preventive services. Methods: Data from the Medical Expenditure Panel Survey and the Area Resource Files (1996-1998) are used to identify the individual-and county-level predictors of five types of preventive services (n = 49,063). Results: County racial or ethnic composition is associated with the utilization of certain preventive services, net of individual-level characteristics. Specifically, individuals in high percent Hispanic counties are more likely to report cholesterol screenings, while those in counties with more blacks are more likely to have regular mammograms. Moreover, county racial or ethnic composition modifies the relationship between individual race or ethnicity and preventive use. In particular, Hispanic individuals who reside in high percent black counties report higher levels of utilization for most preventive services compared to Hispanics living in other counties. Conclusions: Physical and social environments are key determinants of health behaviors and outcomes. Future studies should take into account the racial or ethnic composition of an area and how this interacts with individual race or ethnicity when investigating predictors of preventive care use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - county characteristics
KW - racial disparities
KW - ethnic disparities
KW - preventive services
KW - preventive service utilization
KW - 2004
KW - Health Care Services
KW - Health Care Utilization
KW - Prevention
KW - Racial and Ethnic Differences
KW - 2004
DO - 10.1016/j.ypmed.2004.02.039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18981-007&site=ehost-live&scope=site
UR - reindl@prc.utexas.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18981-009
AN - 2004-18981-009
AU - Amitai, Yona
AU - Fisher, Nirah
AU - Haringman, Miri
AU - Meiraz, Hana
AU - Baram, Nira
AU - Leventhal, Alex
T1 - Increased awareness, knowledge and utilization of preconceptional folic acid in Israel following a national campaign.
JF - Preventive Medicine: An International Journal Devoted to Practice and Theory
JO - Preventive Medicine: An International Journal Devoted to Practice and Theory
JA - Prev Med
Y1 - 2004/10//
VL - 39
IS - 4
SP - 731
EP - 737
CY - Netherlands
PB - Elsevier Science
SN - 0091-7435
AD - Amitai, Yona, Department of Mother Child and Adolescent Health, Ministry of Health, 20 King David St., Jerusalem, Israel, 91010
N1 - Accession Number: 2004-18981-009. PMID: 15351539 Other Journal Title: Preventative Medicine: An International Journal Devoted to Practice & Theory. Partial author list: First Author & Affiliation: Amitai, Yona; Department of Mother, Child and Adolescent Health, Ministry of Health, Jerusalem, Israel. Release Date: 20050321. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Awareness; Folic Acid; Human Females; Neural Development; Prenatal Development. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Location: Israel. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2004.
AB - Background: To decrease the risk of neural tube defects (NTDs), the Israeli Ministry of Health (MOH) issued guidelines in August 2000 recommending daily folic acid (FA) supplementation for women in their childbearing age, and concurrently launched a national FA campaign. Campaign effects were assessed by comparing the results of a survey done in 2002 with a baseline survey done in June 2000. Methods: Both surveys were done within the network of the Public Health Services' Mother and Child Health Clinics (MCHC). Nursing staff conducted structured interviews of pregnant women and mothers of newborn infants. Results: In the 2002 survey (n = 1661), awareness was 85%, correct knowledge was 77.7% and 30.5% utilized FA preconceptionally. Ratios of awareness, knowledge and utilization were highest among women with post-university education (93%, 84%, 46%), and awareness and utilization were significantly higher in the 25-29 year age bracket (90%, 35%). In the baseline 2000 survey (n = 1719), FA awareness had been 54.6%, knowledge of the benefits of FA was 17.6% and preconceptional utilization was reported by a mere 5.2%. Conclusions: A national periconceptional FA campaign in Israel resulted in significant increases in awareness and correct knowledge, and a sixfold increase in its intake. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health awareness
KW - neural tube defects
KW - preconceptional folic acid
KW - compaign effects
KW - 2004
KW - Awareness
KW - Folic Acid
KW - Human Females
KW - Neural Development
KW - Prenatal Development
KW - 2004
DO - 10.1016/j.ypmed.2004.02.042
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18981-009&site=ehost-live&scope=site
UR - yona.amitai@moh.health.gov.il
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18524-007
AN - 2004-18524-007
AU - McInnes, K.
AU - Landon, B. E.
AU - Malitz, F. E.
AU - Wilson, I. B.
AU - Marsden, P. V.
AU - Fleishman, J. A.
AU - Gustafson, D. H.
AU - Cleary, Paul D.
T1 - Differences in patient and clinic characteristics at CARE Act funded versus non-CARE Act funded HIV clinics.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2004/10//
VL - 16
IS - 7
SP - 851
EP - 857
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Cleary, Paul D., Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA, US, 02115-5899
N1 - Accession Number: 2004-18524-007. PMID: 15385240 Partial author list: First Author & Affiliation: McInnes, K.; Department of Health Care Policy, Harvard Medical School, Boston, MA, US. Release Date: 20041213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Client Characteristics; HIV; Risk Factors; Health Care Policy. Minor Descriptor: AIDS Prevention; Health Care Costs; Infectious Disorders. Classification: Medical Treatment of Physical Illness (3363); Immunological Disorders (3291). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2004.
AB - The Ryan White CARE Act supports comprehensive care to persons with HIV infection. With an annual budget of over $1 billion, it is the largest federally funded programme for HIV care in the USA. We analysed data from the HIV Costs and Services Utilization Study, a nationally representative sample of HIV patients. Patient data were collected in 1996-97 and clinic data were collected in 1998-99. We examined whether CARE Act funded clinics differed from other HIV clinics in (1) the characteristics of their patients, and (2) their organization, staffing, and services. We found that patients at CARE Act clinics were younger, less educated, poorer, and more likely to be female, non-white, unemployed, uninsured, and have heterosexual contact as an HIV risk factor, compared to patients at other HIV clinics. CARE Act clinics tended to specialize in HIV care, had more infectious disease specialists, had fewer total patients, and provided more support services (e.g. mental health, nutrition, case management, child care). These results are consistent with findings of other studies that were limited by non-probability samples or restricted geographical areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient characterstics
KW - clinic characteristics
KW - health care policy
KW - HIV infection
KW - child care
KW - risk factor
KW - health care cost
KW - federal funding
KW - 2004
KW - AIDS
KW - Client Characteristics
KW - HIV
KW - Risk Factors
KW - Health Care Policy
KW - AIDS Prevention
KW - Health Care Costs
KW - Infectious Disorders
KW - 2004
DO - 10.1080/09540120412331290202
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18524-007&site=ehost-live&scope=site
UR - ORCID: 0000-0002-0246-738X
UR -
UR - cleary@hcp.med.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18524-008
AN - 2004-18524-008
AU - London, Andrew S.
AU - Wilmoth, J. M.
AU - Fleishman, J. A.
T1 - Moving for care: Findings from the US HIV Cost and Services Utilization Study.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2004/10//
VL - 16
IS - 7
SP - 858
EP - 875
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - London, Andrew S., Maxwell School of Citizenship & Public Affairs, Center for Policy Research, Syracuse University, 426 Eggers Hall, Syracuse, NY, US, 13244-1020
N1 - Accession Number: 2004-18524-008. PMID: 15385241 Partial author list: First Author & Affiliation: London, Andrew S.; Department of Sociology, Center for Policy Research, Syracuse University, Syracuse, NY, US. Release Date: 20041213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Initiative in Population Research Colloquium, Feb, 2002, Ohio State University, Columbus, OH, US. Conference Note: Earlier versions of this paper were presented at the aforementioned conference and the annual meeting of the Population Association of America, Minneapolis, MN, 1-3 May 2003. Major Descriptor: Demographic Characteristics; Health Care Costs; Health Care Services; Health Care Utilization; HIV. Minor Descriptor: Client Characteristics. Classification: Medical Treatment of Physical Illness (3363); Immunological Disorders (3291). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: Oct, 2004.
AB - This paper examines sociodemographic and HIV-related factors associated with moving post-HIV diagnosis for non-care- and care-related reasons (versus never moving post-HIV diagnosis). Distinctions are made between those who move for informal care only, formal care only, or informal and formal care. Data come from the nationally representative US HIV Cost and Services Utilization Study (N=2,864). Overall, 31.8% moved at least once post-HIV diagnosis and 16.3% moved most recently for care. Among those who moved for care, 32.6% moved for informal care only, 26.8% for formal care only, and 40.6% moved for both. Post-HIV diagnosis moves for reasons unrelated to care were less likely among African Americans and older persons, and more likely among those with longer durations positive. Moves for care were less likely among African Americans, older persons, and persons with higher educational attainments, while they were more likely among those with an AIDS diagnosis and longer durations HIV-positive. Among those who moved for care, women and persons with higher incomes were less likely to move for formal or mixed care than informal care only. Given that moving for care may reflect disparities in access to care and unmet needs, additional analyses with more detailed data are warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV diagnosis
KW - informal care
KW - sociodemographic factor
KW - educational status
KW - health care cost
KW - health care services utilization
KW - 2004
KW - Demographic Characteristics
KW - Health Care Costs
KW - Health Care Services
KW - Health Care Utilization
KW - HIV
KW - Client Characteristics
KW - 2004
DO - 10.1080/09540120412331290149
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18524-008&site=ehost-live&scope=site
UR - aslondon@maxwell.syr.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18524-013
AN - 2004-18524-013
AU - Wood, S. A.
AU - Tobias, C.
AU - McCree, J.
T1 - Medication adherence for HIV positive women caring for children: In their own words.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2004/10//
VL - 16
IS - 7
SP - 909
EP - 913
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Wood, S. A., School of Social Welfare, State University of New York, Richardson, 218, 135 Western Avenue, Albany, NY, US, 12222
N1 - Accession Number: 2004-18524-013. PMID: 15385246 Partial author list: First Author & Affiliation: Wood, S. A.; School of Social Welfare, State University of New York, Albany, NY, US. Release Date: 20041213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; HIV; Human Females; Treatment Compliance. Minor Descriptor: Distress; Drug Therapy; Treatment Planning. Classification: Medical Treatment of Physical Illness (3363); Immunological Disorders (3291). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 2004.
AB - Few studies have directly focused on adherence to highly active antiretroviral medication (HAART) in HIV positive women caring for children. These women may have unique barriers and facilitators to taking medication, and a deeper understanding of their adherence patterns could enhance intervention strategies. A total of 36 HIV positive women who care for children less than 18 years of age were interviewed regarding their patterns and decision around taking HAART. The study group was comprised of 19 Latinas, 10 Euro-Americans, 5 African Americans and 2 Cape Verdeans. The mean length of time the women knew they were HIV positive was 11.15 years. Adherence patterns shifted over the course of the women's HIV history. The participants continually discussed medication adherence within the context of events and relationships that either upset or stabilized their adherence. The following themes emerged: (1) shifting adherence patterns; (2) reasons for adherence; (3) reasons for non-adherence; (4) the relationship between distress level and medication adherence; (5) interpersonal relationship as barrier or facilitator of medication adherence; and (6) children as facilitators in adherence. Providers need to be aware of the shifting nature of adherence and its relationship to psychosocial functioning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medication adherence
KW - HIV infection
KW - treatment strategy
KW - distress
KW - child care
KW - women
KW - 2004
KW - Child Care
KW - HIV
KW - Human Females
KW - Treatment Compliance
KW - Distress
KW - Drug Therapy
KW - Treatment Planning
KW - 2004
DO - 10.1080/09540120412331290158
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18524-013&site=ehost-live&scope=site
UR - sawood@albany.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19231-002
AN - 2004-19231-002
AU - Rozario, Philip A.
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
T1 - Comparing the Congruency of Self-Report and Provider Records of Depressed Elders' Service Use by Provider Type.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2004/10//
VL - 42
IS - 10
SP - 952
EP - 959
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Rozario, Philip A., Adelphi University School of Social Work, 1 South Avenue, Garden City, NY, US, 11530
N1 - Accession Number: 2004-19231-002. PMID: 15377927 Partial author list: First Author & Affiliation: Rozario, Philip A.; Adelphi University School of Social Work, Garden City, NY, US. Release Date: 20041108. Correction Date: 20090706. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Health Care Utilization; Major Depression; Medical Records; Self-Report. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Mini Mental State Examination; Geriatric Depression Scale DOI: 10.1037/t00930-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2004.
AB - Background: An accurate accounting of service use is necessary to understand use patterns and outcomes. Yet such an accounting remains challenging, in part because of the reliability and validity of the collection method and sources. Objectives: This study describes 2 methods of data collection: self-report and the retrieval of provider records. We report on the effort, yield, and challenges of retrieving records. Then, we compare the congruency and completeness of 2 methods: self-report and provider records. Finally, we examine the impact of various patients' characteristics on congruency rates. Method: Our sample of depressed older participants was recruited from an inpatient geropsychiatry unit before they were discharged into the community. We interviewed participants at 3 points during a 6-month period. Provider records were obtained across provider type, based on self-report and snowballing technique. We calculated congruency rates and examined completeness of either data source on 91 participants with completed provider records. Using logistic regression, we examined the differences in congruency by provider type as well as factors related to the congruency. Results: The record retrieval process is labor-intensive and challenging. We found that congruency rates were statistically higher for pharmacy and hospital providers and lower for physicians. We also found higher counts of service use, higher depression levels, and being married were significantly related with lower congruency between self-report of service use and provider records. Discussion: Although we found relatively high congruency rates between self-report and service records, the choice of methods depends on the purpose of the research and breadth of provider types. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self-report
KW - health care provider records
KW - depressed elders
KW - health care service use
KW - patient characteristics
KW - 2004
KW - Client Characteristics
KW - Health Care Utilization
KW - Major Depression
KW - Medical Records
KW - Self-Report
KW - 2004
DO - 10.1097/00005650-200410000-00003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19231-002&site=ehost-live&scope=site
UR - rozario@adelphi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-18801-002
AN - 2004-18801-002
AU - Chen, Frederick M.
AU - Bauchner, Howard
AU - Burstin, Helen
T1 - A Call for Outcomes Research in Medical Education.
JF - Academic Medicine
JO - Academic Medicine
JA - Acad Med
Y1 - 2004/10//
VL - 79
IS - 10
SP - 955
EP - 960
CY - US
PB - Lippincott Williams & Wilkins
SN - 1040-2446
SN - 1938-808X
AD - Chen, Frederick M., Department of Family Medicine, University of Washington, Box 354982, Seattle, WA, US, 98195
N1 - Accession Number: 2004-18801-002. PMID: 15383351 Other Journal Title: Journal of Medical Education. Partial author list: First Author & Affiliation: Chen, Frederick M.; Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20050314. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health Care Services; Medical Education. Classification: Research Methods & Experimental Design (2260); Professional Education & Training (3410). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2004.
AB - The primary goal of medical education is to produce physicians who deliver high-quality health care. Recent calls for greater accountability in medical education and the development of outcomes research methodologies should encourage a new research effort to examine the effects of medical training upon clinical outcomes. The authors offer a research agenda that links medical education and quality of health care and give specific examples of potential research projects that would begin to examine that relationship. A proposed model of patient outcomes research in medical education recognizes the contributory effects of health care system-level factors as well as the continuum of medical education, process measures, and individual training and preparedness to deliver high-quality care. There exists an opportunity to create a research agenda in medical education outcomes research that is multidisciplinary, broad based, and focused on patient-centered outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - research outcomes
KW - medical education
KW - health care
KW - medical training
KW - 2004
KW - Experimentation
KW - Health Care Services
KW - Medical Education
KW - 2004
DO - 10.1097/00001888-200410000-00010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-18801-002&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8368-9805
UR -
UR - fchen@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gordon, Christopher M.
AU - Stall, Ron
AU - Cheever, Laura W.
T1 - Prevention Interventions With Persons Living With HIV/AIDS.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2004/10/02/10/1/2004 Supplement
VL - 37
M3 - Article
SP - S53
EP - S57
SN - 15254135
AB - Discusses prevention interventions for HIV/AIDS-positive persons in the United States. Behavioral risk reduction; Integrative intervention to address the challenges of medical care, adherence and prevention needs; Rollout of antivirals in other countries.
KW - AIDS patients
KW - HIV-positive persons
KW - ANTIVIRAL agents
KW - MEDICAL care
KW - PATIENT compliance
KW - UNITED States
N1 - Accession Number: 14699604; Gordon, Christopher M. 1; Email Address: cgordon1@mail.nih.gov Stall, Ron 2 Cheever, Laura W. 3; Affiliation: 1: National Institute of Mental Health (NIMH), Center for Mental Health Research on AIDS, Bethesda, MD 2: Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Prevention Research Branch, GA 3: Health Resources and Services Administration, HIV/AIDS Bureau, MD; Source Info: 10/1/2004 Supplement, Vol. 37, pS53; Subject Term: AIDS patients; Subject Term: HIV-positive persons; Subject Term: ANTIVIRAL agents; Subject Term: MEDICAL care; Subject Term: PATIENT compliance; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Purcell, David W.
AU - Metsch, Lisa R.
AU - Latka, Mary
AU - Santibanez, Scott
AU - Gómez, Cynthia A.
AU - Eldred, Lois
AU - Latkin, Carl A.
T1 - Interventions for Seropositive Injectors Research and Evaluation.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2004/10/02/10/1/2004 Supplement
VL - 37
M3 - Article
SP - S110
EP - S118
SN - 15254135
AB - Discusses the development of Interventions for Seropositive Injectors--Research and Evaluation, a randomized controlled trial of an integrated intervention for HIV-positive intravenous drug users in the United States. Integrated behavioral intervention; Patient adherence; Risk reduction.
KW - HIV infections -- Prevention
KW - HIV-positive persons
KW - INTRAVENOUS drug abuse
KW - CLINICAL trials
KW - PATIENT compliance
KW - UNITED States
KW - adherence
KW - HIV risk behavior
KW - HIV-positive
KW - injection drug users
KW - injection risk behavior
KW - medical care
N1 - Accession Number: 14699611; Purcell, David W. 1; Email Address: dpurcell@cdc.gov Metsch, Lisa R. 2 Latka, Mary 3 Santibanez, Scott 1 Gómez, Cynthia A. 4 Eldred, Lois 5 Latkin, Carl A. 6; Affiliation: 1: Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 2: Department of Epidemiology and Public Health, University of Miami, Miami, FL 3: New York Academy of Medicine University, New York City, NY 4: Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, CA 5: Health Resources and Services Administration, Rockvi]le, MD 6: Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD; Source Info: 10/1/2004 Supplement, Vol. 37, pS110; Subject Term: HIV infections -- Prevention; Subject Term: HIV-positive persons; Subject Term: INTRAVENOUS drug abuse; Subject Term: CLINICAL trials; Subject Term: PATIENT compliance; Subject Term: UNITED States; Author-Supplied Keyword: adherence; Author-Supplied Keyword: HIV risk behavior; Author-Supplied Keyword: HIV-positive; Author-Supplied Keyword: injection drug users; Author-Supplied Keyword: injection risk behavior; Author-Supplied Keyword: medical care; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wise, Robert P.
AU - Iskander, John
AU - Pratt, R. Douglas
AU - Campbell, Scott
AU - Ball, Robert
AU - Pless, Robert P.
AU - Braun, M. Miles
T1 - Postlicensure Safety Surveillance for 7-Valent Pneumococcal Conjugate Vaccine.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/10/13/
VL - 292
IS - 14
M3 - Article
SP - 1702
EP - 1710
SN - 00987484
AB - Context Clinical trials evaluate a vaccine’s safety before approval, but some risks may escape detection or adequate characterization until larger population exposures occur after licensure. Objective To summarize reports of events occurring after vaccination with 7-valent pneumococcal conjugate vaccine (PCV), including those that may warrant further investigation to assess possible causation by PCV. Design Descriptive epidemiology of reports submitted to the Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance database. Setting and Patients United States during first 2 years after licensure of PCV (February 2000 through February 2002). Reports studied were for children younger than 18 years and vaccinated with PCV. Main Outcome Measures Numbers and proportional distributions of reports. Results A total of 4154 reports of events following PCV were submitted to VAERS, for a rate of 13.2 reports per 100 000 doses distributed. Multiple vaccines were given in 74.3% of reports.The most frequently reported symptoms and signs included fever, injection site reactions, fussiness, rashes, and urticaria. Serious events were described in 14.6% of reports. There were 117 deaths, 23 reports of positive rechallenges, and 34 cases of invasive pneumococcal infections possibly representing vaccine failure. Immune-mediated events occurred in 31.3% of reports. All 14 patients with anaphylactic or anaphylactoid reactions survived. Thrombocytopenia developed in 14 patients and serum sickness in 6 others. Neurologic symptoms occurred in 38% of reports. Seizures described in 393 reports included 94 febrile seizures. Conclusions The majority of reports to VAERS in the first 2 years after licensure of PCV described generally minor adverse events previously identified in clinical trials. The proportion of reports portraying serious events was similar to that for other vaccines. Although there are important limitations in passive surveillance data, and caution in their interpretation is necessary, symptoms experienced by a few children more than once after successive PCV doses, including allergic reactions, prolonged or abnormal crying, fussiness, dyspnea, and gastrointestinal distress, warrant continued surveillance, as do reports of rare but potentially serious events, such as seizures, anaphylactic or anaphylactoid reactions, serum sickness, and thrombocytopenia. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - PREVENTIVE medicine
KW - CLINICAL trials
KW - VACCINATION
KW - DISEASES
KW - PUBLIC health
KW - Drug Approval
KW - Drug Reaction, Adverse
KW - Drug Surveillance, Postmarketing see Product Surveillance, Postmarketing
KW - Pneumococcal Vaccines
KW - Product Surveillance, Postmarketing
N1 - Accession Number: 14676959; Wise, Robert P. 1 Iskander, John 1 Pratt, R. Douglas 1 Campbell, Scott 1 Ball, Robert 1 Pless, Robert P. 1 Braun, M. Miles 1; Affiliation: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology (Drs Wise, Ball, and Braun), and Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review (Dr Pratt), Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md; Immunization Safety Branch, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga (Drs Iskander and Pless and Mr Campbell); and Immunization Safety Unit, Immunization and Respiratory Infections Division, Centre for Infectious Disease Prevention and Control Health Canada, Ottawa, Ontario (Dr Pless).; Source Info: 10/13/2004, Vol. 292 Issue 14, p1702; Subject Term: MEDICAL research; Subject Term: PREVENTIVE medicine; Subject Term: CLINICAL trials; Subject Term: VACCINATION; Subject Term: DISEASES; Subject Term: PUBLIC health; Author-Supplied Keyword: Drug Approval; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Drug Surveillance, Postmarketing see Product Surveillance, Postmarketing; Author-Supplied Keyword: Pneumococcal Vaccines; Author-Supplied Keyword: Product Surveillance, Postmarketing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106579347
T1 - Postlicensure safety surveillance for 7-valent pneumococcal conjugate vaccine.
AU - Wise RP
AU - Iskander J
AU - Pratt RD
AU - Campbell S
AU - Ball R
AU - Pless RP
AU - Braun MM
AU - Wise, Robert P
AU - Iskander, John
AU - Pratt, R Douglas
AU - Campbell, Scott
AU - Ball, Robert
AU - Pless, Robert P
AU - Braun, M Miles
Y1 - 2004/10/13/
N1 - Accession Number: 106579347. Language: English. Entry Date: 20050211. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Adverse Drug Event
KW - Immunization -- Adverse Effects -- In Infancy and Childhood
KW - Pneumococcal Vaccine -- Administration and Dosage -- In Infancy and Childhood
KW - Pneumococcal Vaccine -- Adverse Effects -- In Infancy and Childhood
KW - Adolescence
KW - Anaphylaxis -- Chemically Induced
KW - Child
KW - Child, Preschool
KW - Infant
KW - Product Surveillance
KW - Seizures -- Chemically Induced
KW - Serum Sickness -- Chemically Induced
KW - Thrombocytopenia -- Chemically Induced
KW - Human
SP - 1702
EP - 1710
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 292
IS - 14
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Clinical trials evaluate a vaccine's safety before approval, but some risks may escape detection or adequate characterization until larger population exposures occur after licensure.Objective: To summarize reports of events occurring after vaccination with 7-valent pneumococcal conjugate vaccine (PCV), including those that may warrant further investigation to assess possible causation by PCV.Design: Descriptive epidemiology of reports submitted to the Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance database.Setting and Patients: United States during first 2 years after licensure of PCV (February 2000 through February 2002). Reports studied were for children younger than 18 years and vaccinated with PCV.Main Outcome Measures: Numbers and proportional distributions of reports.Results: A total of 4154 reports of events following PCV were submitted to VAERS, for a rate of 13.2 reports per 100,000 doses distributed. Multiple vaccines were given in 74.3% of reports. The most frequently reported symptoms and signs included fever, injection site reactions, fussiness, rashes, and urticaria. Serious events were described in 14.6% of reports. There were 117 deaths, 23 reports of positive rechallenges, and 34 cases of invasive pneumococcal infections possibly representing vaccine failure. Immune-mediated events occurred in 31.3% of reports. All 14 patients with anaphylactic or anaphylactoid reactions survived. Thrombocytopenia developed in 14 patients and serum sickness in 6 others. Neurologic symptoms occurred in 38% of reports. Seizures described in 393 reports included 94 febrile seizures.Conclusions: The majority of reports to VAERS in the first 2 years after licensure of PCV described generally minor adverse events previously identified in clinical trials. The proportion of reports portraying serious events was similar to that for other vaccines. Although there are important limitations in passive surveillance data, and caution in their interpretation is necessary, symptoms experienced by a few children more than once after successive PCV doses, including allergic reactions, prolonged or abnormal crying, fussiness, dyspnea, and gastrointestinal distress, warrant continued surveillance, as do reports of rare but potentially serious events, such as seizures, anaphylactic or anaphylactoid reactions, serum sickness, and thrombocytopenia.
SN - 0098-7484
AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md 20852-1448, USA
AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-225, 1401 Rockville Pike, Rockville, MD 20852-1448; R.P.Wise@cber.fda.gov
U2 - PMID: 15479935.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106579347&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106586556
T1 - Problems with drug-eluting coronary stents -- the FDA perspective.
AU - Muni NI
AU - Gross TP
Y1 - 2004/10/14/
N1 - Accession Number: 106586556. Language: English. Entry Date: 20050225. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Angioplasty, Transluminal, Percutaneous Coronary
KW - Drug Delivery Systems
KW - Stents -- Adverse Effects
KW - Thrombosis -- Etiology
KW - Coronary Disease -- Therapy
KW - Device Approval
KW - Equipment Design
KW - Equipment Failure
KW - Paclitaxel
KW - Sirolimus
KW - Stents -- Methods
KW - United States
KW - United States Food and Drug Administration
SP - 1593
EP - 1595
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 351
IS - 16
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 15483274.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106586556&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Clancy, Carolyn M.
T1 - The new faces of primary care
JO - American Journal of Medicine
JF - American Journal of Medicine
Y1 - 2004/10/15/
VL - 117
IS - 8
M3 - Editorial
SP - 613
EP - 614
SN - 00029343
N1 - Accession Number: 14582061; Clancy, Carolyn M. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland; Source Info: Oct2004, Vol. 117 Issue 8, p613; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.amjmed.2004.08.005
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Winthrop, Kevin L.
AU - Siegel, Jeffrey N.
T1 - Tuberculosis Cases Associated with Infliximab and Etanercept.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/10/15/
VL - 39
IS - 8
M3 - Letter
SP - 1256
EP - 1257
SN - 10584838
AB - Presents a letter to the editor focusing on tuberculosis cases associated with infliximab and etanercept.
KW - Tuberculosis
KW - Letters to the editor
N1 - Accession Number: 14610023; Winthrop, Kevin L. 1; Siegel, Jeffrey N. 2; Email Address: jeffrey.siegel@fda.hhs.gov; Affiliations: 1: Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.; 2: Division of Therapeutic Biologic Internal Medicine Products, Office of Drug Evaluation VI, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; Issue Info: 10/15/2004, Vol. 39 Issue 8, p1256; Thesaurus Term: Tuberculosis; Subject Term: Letters to the editor; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dragunsky, Eugenia M.
AU - Ivanov, Alexander P.
AU - Wells, Virgen R.
AU - Ivshina, Anna V.
AU - Rezapkin, Gennady V.
AU - Abe, Shinobu
AU - Potapova, Svetlana G.
AU - Enterline, Joan C.
AU - Hashizume, Sou
AU - Chumakov, Konstantin M.
T1 - Evaluation of Immunogenicity and Protective Properties of Inactivated Poliovirus Vaccines: A New Surrogate Method for Predicting Vaccine Efficacy.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2004/10/15/
VL - 190
IS - 8
M3 - Article
SP - 1404
EP - 1412
SN - 00221899
AB - An assay for the evaluation of protective properties of inactivated poliovirus vaccines (IPVs) in transgenic (Tg) mice susceptible to poliovirus has been developed and optimized for type 2 IPV. This method was used to compare the immunogenicity and protective properties of experimental IPV produced from the attenuated Sabin strain (sIPV) with those of conventional IPV (cIPV) produced from the wild-type (wt) poliovirus MEF-1 strain. Modified enzyme-linked immunosorbent assays (ELISAs) were used to measure immune response in serum and saliva samples from test mice. Tg mice were vaccinated and were challenged either with wt poliovirus or virulent poliovirus derived from the vaccine strain. Compared with cIPV, sIPV induced lower levels of antibodies and did not completely protect mice against challenge with wt virus but did protect mice against challenge with the virulent vaccine-derived strain. This may be due to an 18% nucleotide difference between the MEF-1 and Sabin 2 strains, resulting in 72 amino acid substitutions and leading to antigenic dissimilarity. Immunological properties of both strains, revealed by cross-neutralization tests and ELISAs, confirmed that MEF-1 possesses broader immunogenicity than does Sabin 2. This animal model may be used for the assessment of new IPVs and of combination vaccines containing an IPV component. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Poliovirus
KW - Viral vaccines
KW - Transgenic mice
KW - Serum
KW - Saliva
N1 - Accession Number: 14518450; Dragunsky, Eugenia M. 1; Email Address: dragunsky@cber.fda.gov; Ivanov, Alexander P. 1; Wells, Virgen R. 1,2; Ivshina, Anna V. 1; Rezapkin, Gennady V. 1; Abe, Shinobu 3; Potapova, Svetlana G. 1; Enterline, Joan C. 1; Hashizume, Sou 3; Chumakov, Konstantin M. 1; Affiliations: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 2: Systems and Concepts Office, Department of Defense, Fort Belvoir, Virginia; 3: Japan Poliomyelitis Research Institute, Tokyo, Japan; Issue Info: 10/15/2004, Vol. 190 Issue 8, p1404; Thesaurus Term: Immune response; Subject Term: Poliovirus; Subject Term: Viral vaccines; Subject Term: Transgenic mice; Subject Term: Serum; Subject Term: Saliva; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Guest, Stephen
AU - Pilipenko, Evgeny
AU - Sharma, Kamal
AU - Chumakov, Konstantin
AU - Roos, Raymond P.
T1 - Molecular Mechanisms of Attenuation of the Sabin Strain of Poliovirus Type 3.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/10/15/
VL - 78
IS - 20
M3 - Article
SP - 11097
EP - 11107
SN - 0022538X
AB - Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of polio-virus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and a neural cell-specific homologue, nPTB. PTB and nPTB were found to bind to a site directly adjacent to the attenuating mutation, and binding at this site was less efficient on the Sabin3 IRES than on the PV3 IRES. Translation mediated by the PV3 and Sabin3 IRESs in neurons of the chicken embryo spinal cord demonstrated a translation deficit for the Sabin3 IRES that could be rescued by increasing PTB expression in the CNS. These data suggest that the low levels of PTB available in the CNS, coupled to a reduced binding of PTB on the Sabin3 IRES, leads to its CNS-specific attenuation. This study also demonstrates the use of the chicken embryo to easily investigate translation of RNA within a neuron in the CNS of an intact living organism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - GENETICS
KW - VARIATION (Biology)
KW - POLIOVIRUS
KW - ENTEROVIRUSES
KW - PICORNAVIRUSES
N1 - Accession Number: 14746605; Guest, Stephen 1 Pilipenko, Evgeny 1,2 Sharma, Kamal 3 Chumakov, Konstantin 4 Roos, Raymond P. 1,5; Email Address: rroos@neurology.bsd.uchicago.edu; Affiliation: 1: Committee on Microbiology, University of Chicago, Chicago, Illinois 2: Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 3: Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 5: Department of Neurology, Biological Sciences Division, University of Chicago, Chicago, Illinois; Source Info: Oct2004, Vol. 78 Issue 20, p11097; Subject Term: MUTATION (Biology); Subject Term: GENETICS; Subject Term: VARIATION (Biology); Subject Term: POLIOVIRUS; Subject Term: ENTEROVIRUSES; Subject Term: PICORNAVIRUSES; Number of Pages: 11p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.20.11097-11107.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levin, S. M.
AU - Herbert, R.
AU - Moline, J. M.
AU - Todd, A. C.
AU - Stevenson, L.
AU - Landsbergis, P.
AU - Jiang, W.
AU - Skloot, G.
AU - Baron, S.
AU - Enright, P.
T1 - Physical Health Status of World Trade Center Rescue and Recovery Workers and Volunteers—New York City, July 2002–August 2004.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/10/20/
VL - 292
IS - 15
M3 - Article
SP - 1811
EP - 1813
SN - 00987484
AB - Discusses the physical health status of World Trade Center rescue and recovery workers and volunteers in New York City from July 2002 to August 2004. Statistical findings of the CDC National Institute for Occupational Safety and Health, which supported the WTC Worker and Volunteer Medical Screening Program; Information on the screening evaluation, the participants, and criteria for WTC-related symptoms; Spirometry findings; Editorial note from the CDC about the limitations in this study.
KW - MEDICAL screening
KW - HEALTH risk assessment
KW - PUBLIC health
KW - HAZARDOUS substances
KW - HEALTH status indicators
KW - SEPTEMBER 11 Terrorist Attacks, 2001
KW - RESCUE work
KW - VOLUNTEERS
KW - DISASTER medicine
KW - NEW York (N.Y.)
KW - NEW York (State)
KW - UNITED States
KW - FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION
KW - New York City
KW - Occupational Exposure
KW - Terrorism
KW - WORLD Trade Center (New York, N.Y. : 1970-2001)
N1 - Accession Number: 14789156; Levin, S. M. 1 Herbert, R. 1 Moline, J. M. 1 Todd, A. C. 1 Stevenson, L. 1 Landsbergis, P. 1 Jiang, W. 1 Skloot, G. 1 Baron, S. 2 Enright, P. 2; Affiliation: 1: Mount Sinai School of Medicine, New York, New York 2: Div. of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 10/20/2004, Vol. 292 Issue 15, p1811; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; Subject Term: PUBLIC health; Subject Term: HAZARDOUS substances; Subject Term: HEALTH status indicators; Subject Term: SEPTEMBER 11 Terrorist Attacks, 2001; Subject Term: RESCUE work; Subject Term: VOLUNTEERS; Subject Term: DISASTER medicine; Subject Term: NEW York (N.Y.); Subject Term: NEW York (State); Subject Term: UNITED States; Author-Supplied Keyword: FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION; Author-Supplied Keyword: New York City; Author-Supplied Keyword: Occupational Exposure; Author-Supplied Keyword: Terrorism; Company/Entity: WORLD Trade Center (New York, N.Y. : 1970-2001); NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dagher, Ramzi
AU - Johnson, John
AU - Williams, Grant
AU - Keegan, Patricia
AU - Pazdur, Richard
T1 - Accelerated Approval of Oncology Products: A Decade of Experience.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2004/10/20/
VL - 96
IS - 20
M3 - Article
SP - 1500
EP - 1509
SN - 00278874
AB - We review the regulatory history of the accelerated approval process and summarize the U.S. Food and Drug Administration experience with accelerated approvals in oncology. The accelerated approval regulations, promulgated in 1992, allow approval of drugs for serious or life-threatening diseases on the basis of a surrogate endpoint that is reasonably likely to predict clinical benefit, such as survival or symptom benefit, pending completion of studies designed to confirm clinical benefit, referred to as phase 4 commitments, which are required to be conducted with due diligence. From 1992 to 2004, 22 applications involving anticancer drugs or biologics were approved. Of these 22 applications, accelerated approval was granted to 15 on the basis of findings from studies without an active comparator (i.e., single-arm studies or studies comparing two dose levels) and to the remaining seven on the basis of one or more randomized studies. Of the 22 approved applications, six (i.e., applications for dexrazoxane, irinotecan, capecitabine, docetaxel, imatinib mesylate, and oxaliplatin) have had one or more indications converted to regular approval. This review reports information that was presented at an Oncologic Drugs Advisory Committee meeting held in March 2003; it also presents a discussion of accelerated approval study designs, the study populations evaluated in the accelerated approval and confirmatory settings, and the integration of accelerated approval into a comprehensive drug development plan. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG approval
KW - DRUG laws & regulations
KW - BIOLOGICALS
KW - MEDICAL supplies
KW - ONCOLOGY
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 14967514; Dagher, Ramzi 1; Email Address: dagherr@cder.fda.gov Johnson, John 1 Williams, Grant 1 Keegan, Patricia 2 Pazdur, Richard 1; Affiliation: 1: Division of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville. MD 2: Division of Therapeutic Biological Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville. MD; Source Info: 10/20/2004, Vol. 96 Issue 20, p1500; Subject Term: DRUG approval; Subject Term: DRUG laws & regulations; Subject Term: BIOLOGICALS; Subject Term: MEDICAL supplies; Subject Term: ONCOLOGY; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1093/jnci/djh279
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ho-Yung Lee
AU - Hojin Moon
AU - Kyung-Hee Chun
AU - Yoon-Soo Chang
AU - Khaled Hassan
AU - Lin Ji
AU - Reuben Lotan
AU - Khuri, Fadlo R.
AU - Waun Ki Hong
T1 - Effects of Insulin-like Growth Factor Binding Protein-3 and Farnesyltransferase Inhibitor SCH66336 on Akt Expression and Apoptosis in Non-Small-Cell Lung Cancer Cells.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2004/10/20/
VL - 96
IS - 20
M3 - Article
SP - 1536
EP - 1548
SN - 00278874
AB - Background: Overexpression of insulin-like growth factor binding protein-3 (IGFBP-3) induces apoptosis in non-small-cell lung cancer (NSCLC) cells in vitro and in vivo. However, Ras-mediated signaling pathways could develop resistance to apoptotic activities of IGFBP-3 in NSCLC cells. We thus evaluated the therapeutic potential of the combination of IGFBP-3 and SCH66336, a farnesyltransferase inhibitor that blocks Ras activation, in NSCLC cell lines. Methods: The effects of the combination of adenoviral IGFBP-3 (Ad-IGFBP3) and SCH66336 on proliferation and apoptosis of NSCLC cell lines (H1299, H596, A549, H460, H358, H322, and H226B) were assessed in vitro and in vivo by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, a flow cytometry-based terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay, western blot analyses, and an NSCLC xenograft tumor model. The specific effects of Ad-IGFBP 3 and SCH66336 on mitogen-activated protein kinase and Akt were assessed by using adenoviral vectors that express constitutively active MEK1 or constitutively active Akt. Synergy was assessed by median effect analysis. Results: The combination of Ad-IGFBP3 and SCH66336 had synergistic antiproliferative effects in five cell lines (H1299, H596, A549, H460, and H322). Antiproliferative effects were accompanied by increased apoptosis in H460 cells in vitro. Overexpression of a constitutively active Akt but not a constitutively active MEK-1 rescued H460 cells from apoptosis induced by single or combined treatment of Ad-IGFBP3 and SCH66336. In H1299 tumor xenografts, Ad-IGFBP3 and SCH66336 was associated with decreased tumor volume, increased apoptosis, and decreased Akt levels. Conclusions: The combination of Ad-IGFBP3 and SCH66336 decreased Akt expression and increased apoptosis in NSCLC cells in vitro and in vivo. Simultaneous treatment with IGFBP-3 and SCH66336 may have the potential to be an effective therapeutic strategy in NSCLC. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN-like growth factor-binding proteins
KW - TRANSFERASES
KW - ENZYME inhibitors
KW - SMALL cell lung cancer
KW - CELL lines
KW - CELL proliferation
KW - APOPTOSIS
N1 - Accession Number: 14967518; Ho-Yung Lee 1; Email Address: hlee@mdanderson.org Hojin Moon 2 Kyung-Hee Chun 1 Yoon-Soo Chang 1 Khaled Hassan 1 Lin Ji 3 Reuben Lotan 1 Khuri, Fadlo R. 4 Waun Ki Hong 1; Affiliation: 1: Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research U.S. Food and Drug Administration, Jefferson, AR 3: Department of Thoracic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, TX 4: Department of Hematology and Medical Oncology, Translational Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA; Source Info: 10/20/2004, Vol. 96 Issue 20, p1536; Subject Term: INSULIN-like growth factor-binding proteins; Subject Term: TRANSFERASES; Subject Term: ENZYME inhibitors; Subject Term: SMALL cell lung cancer; Subject Term: CELL lines; Subject Term: CELL proliferation; Subject Term: APOPTOSIS; Number of Pages: 13p; Document Type: Article
L3 - 10.1093/jnci/djh286
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Benkovic, Stanley Anthony
AU - O'Callaghan, James Patrick
AU - Miller, Diane Bemis
T1 - Sensitive indicators of injury reveal hippocampal damage in C57BL/6J mice treated with kainic acid in the absence of tonic–clonic seizures
JO - Brain Research
JF - Brain Research
Y1 - 2004/10/22/
VL - 1024
IS - 1/2
M3 - Article
SP - 59
EP - 76
SN - 00068993
AB - Sensitive indices of neural injury were used to evaluate the time course of kainic acid (KA)-induced hippocampal damage in adult C57BL/6J mice (4 months), a strain previously reported to be resistant to kainate-induced neurotoxicity. Mice were injected systemically with saline or kainate, scored for seizure severity (Racine scale), and allowed to survive 12 h, one, three, or seven days following which they were evaluated for neuropathological changes using histological or biochemical endpoints. Most kainate-treated mice exhibited limited seizure activity (stage 1); however, cupric-silver and Fluoro-Jade B stains revealed significant damage by 12 h post-treatment. Immunohistochemistry and immunoassay of glial fibrillary acidic protein and lectin staining revealed a strong treatment-induced reactive gliosis and microglial activation. Immunostaining for immunoglobulin G revealed a kainate-induced breach in the blood–brain barrier. Nissl and hematoxylin stains provided little information regarding neuronal damage, but revealed the identity of non-resident cells which infiltrated the pyramidal layer. Our data suggest sensitive indicators of neural injury evaluated over a time course, both proximal and distal to treatment, are necessary to reveal the full extent of neuropathological changes which may be underestimated by traditional histological stains. The battery of neuropathological indices reported here reveals the C57BL/6J mouse is sensitive to excitotoxic neural damage caused by kainic acid, in the absence of tonic–clonic seizures. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXIC agents
KW - NERVOUS system -- Diseases
KW - IMMUNOGLOBULINS
KW - AMINO acids
KW - MICE as laboratory animals
KW - Excitotoxicity
KW - Gliosis
KW - Neuropathology
KW - Neurotoxicity
N1 - Accession Number: 14542767; Benkovic, Stanley Anthony 1 O'Callaghan, James Patrick 1 Miller, Diane Bemis; Email Address: dum6@cdc.gov; Affiliation: 1: Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention–National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505, United States; Source Info: Oct2004, Vol. 1024 Issue 1/2, p59; Subject Term: NEUROTOXIC agents; Subject Term: NERVOUS system -- Diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: AMINO acids; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Excitotoxicity; Author-Supplied Keyword: Gliosis; Author-Supplied Keyword: Neuropathology; Author-Supplied Keyword: Neurotoxicity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.brainres.2004.07.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuling Chi
AU - Bo Zhou
AU - Wei-Qing Wang
AU - Sung-Kee Chung
AU - Yong-Uk Kwon
AU - Young-Hoon Ahnd
AU - Young-Tae Chang
AU - Tsujishita, Yosuke
AU - Hurley, James H.
AU - Zhong-Yin Zhan
T1 - Comparative Mechanistic and Substrate Specificity Study of Inositol Polyphosphate 5-Phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/10/22/
VL - 279
IS - 43
M3 - Article
SP - 44987
EP - 44995
SN - 00219258
AB - Inositol-5-phosphatases are important enzymes involved in the regulation of diverse cellular processes from synaptic vesicle recycling to insulin signaling. We describe a comparative study of two representative inositol-5-phosphatases, Schizosaccharomyces pombe synaptojanin (SPsynaptojanin) and human SH2 domaincontaining inositol-5-phosphatase SHIP2. We show that in addition to Mg2+, transition metals such as Mn2+, Co2+, and Ni2+ are also effective activators of SPsynaptojanin. In contrast, Ca2+ and Cu2+ are inhibitory. We provide evidence that Mg2+ binds the same site occupied by Ca2+ observed in the crystal structure of SPsynaptojanin complexed with inositol 1,4-bisphosphate (Ins(1,4)P2). Ionizations important for substrate binding and catalysis are defined for the SPsynaptojanin-catalyzed Ins(1,4,5)P3 reaction. Kinetic analysis with four phosphatidylinositol lipids bearing a 5-phosphate and 54 water-soluble inositol phosphates reveals that SPsynaptojanin and SHIP2 possess much broader substrate specificity than previously appreciated. The rank order for SPsynaptojanin is Ins(2,4,5)P3 > phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) ≈ Ins(4,5)P2 ≈ Ins(1,4,5)P3 ≈ Ins(4,5,6)P3 > PtdIns(3,5)P2 ≈ PtdIns(3,4,5)P3 ≈ Ins(1,2,4,5)P4 ≈ Ins(1,3,4,5)P4 ≈ Ins(2,4,5,6)P4 ≈ Ins(1,2,4,5,6)P5. The rank order for SHIP2 is Ins(1,2,3,4,5)P5 > Ins(1,3,4,5)P4 > PtdIns(3,4,5)P4 ≈ PtdIns(3,5)P2 ≈ Ins(1,4,5,6)P4 ≈ Ins(2,4,5,6)P4. Because inositol phosphate isomers elicit different biological activities, the extended substrate specificity for SPsynaptojanin and SHIP2 suggest that these enzymes likely have multiple roles in cell signaling and may regulate distinct pathways. The unique substrate specificity profiles and the importance of 2-position phosphate in binding also have important implications for the design of potent and selective SPsynaptojanin and SHIP2 inhibitors for pharmacological investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INOSITOL phosphates
KW - POLYPHOSPHATES
KW - INSULIN
KW - SCHIZOSACCHAROMYCES pombe
KW - CELLULAR signal transduction
KW - PROTEINS
N1 - Accession Number: 15158426; Yuling Chi 1 Bo Zhou 1 Wei-Qing Wang 1 Sung-Kee Chung 2 Yong-Uk Kwon 2 Young-Hoon Ahnd 3 Young-Tae Chang 3 Tsujishita, Yosuke 4 Hurley, James H. 4 Zhong-Yin Zhan 1; Email Address: zyzhang@aecom.yu.edu; Affiliation: 1: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461 2: Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Korea 3: Department of Chemistry, New York University, New York, New York 10003 4: Laboratory of Molecular Biology, NIDDK, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892; Source Info: 10/22/2004, Vol. 279 Issue 43, p44987; Subject Term: INOSITOL phosphates; Subject Term: POLYPHOSPHATES; Subject Term: INSULIN; Subject Term: SCHIZOSACCHAROMYCES pombe; Subject Term: CELLULAR signal transduction; Subject Term: PROTEINS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Illustrations: 3 Diagrams, 3 Charts, 9 Graphs; Document Type: Article
L3 - 10.1074/jbc.M406416200
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lord, Peter G.
AU - Papoian, Thomas
T1 - Genomics and Drug Toxicity.
JO - Science
JF - Science
Y1 - 2004/10/22/
VL - 306
IS - 5696
M3 - Editorial
SP - 575
EP - 575
PB - American Association for the Advancement of Science
SN - 00368075
AB - The article focuses on the analysis of gene expression profiles which is now actively used alongside conventional toxicological assays to assess drug safety. Such toxicogenomic analysis is being used to predict drug toxicities and to gain a more in-depth understanding of toxic mechanisms, so that more successful drug candidates can be selected. The use of toxicogenomics also has promise in proving hypotheses that support safe drug use in humans through a mechanistic understanding of toxicities found in drug-treated animals.
KW - GENE expression
KW - DRUGS -- Toxicology
KW - GENOMICS
KW - DRUG abuse
KW - BIOLOGICAL assay
KW - DRUGS -- Standards
N1 - Accession Number: 14884197; Lord, Peter G. 1 Papoian, Thomas 2; Affiliation: 1: Pharmaceutical Research and Development at Johnson & Johnson in Raritan, NJ. 2: U.S. Food and Drug Administration in Rockville, MD.; Source Info: 10/22/2004, Vol. 306 Issue 5696, p575; Subject Term: GENE expression; Subject Term: DRUGS -- Toxicology; Subject Term: GENOMICS; Subject Term: DRUG abuse; Subject Term: BIOLOGICAL assay; Subject Term: DRUGS -- Standards; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 1p; Document Type: Editorial; Full Text Word Count: 668
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guiochon, Georges A.
AU - Beaver, Lois Ann
T1 - Progress and future of instrumental analytical chemistry applied to the environment
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2004/10/25/
VL - 524
IS - 1/2
M3 - Article
SP - 1
EP - 14
SN - 00032670
AB - The recent trends in the development of environmental analysis are reviewed with emphasis on the progress of extraction techniques, of methods of analysis of pesticide residues in food, of the search for chemical and biological agents released into the environment, and of analytical instrumentation. A variety of new sorbents have been synthesized for the extraction and concentration of pollutants, including general purpose adsorbents (e.g., porous polystyrene/divinylbenzene resins) and polymers imprinted for specific compounds. New, faster, more selective and sensitive methods have been developed to improve analytical performance, e.g., synthetic fibers in the air pollution, stirbars coated with polymethylsiloxane. Bidimensional gas chromatography has brought a considerable leap in separation power and sensitivity. Finally the combination of open tubular columns and miniaturized quadrupole mass spectrometer allows the rapid identification of viral agents or a wide variety of chemicals. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYTICAL chemistry
KW - POLLUTANTS
KW - BIOLOGICAL decontamination
KW - WASTE products
KW - Biological agents
KW - Contaminants
KW - Environment
KW - Instrumental analytical chemistry
N1 - Accession Number: 14511624; Guiochon, Georges A. 1; Email Address: guiochon@utk.edu Beaver, Lois Ann 2; Affiliation: 1: The University of Tennessee, Knoxville, TN 37996-1600, USA 2: Food and Drug Administration, Rockville, MD 20857, USA; Source Info: Oct2004, Vol. 524 Issue 1/2, p1; Subject Term: ANALYTICAL chemistry; Subject Term: POLLUTANTS; Subject Term: BIOLOGICAL decontamination; Subject Term: WASTE products; Author-Supplied Keyword: Biological agents; Author-Supplied Keyword: Contaminants; Author-Supplied Keyword: Environment; Author-Supplied Keyword: Instrumental analytical chemistry; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 423930 Recyclable Material Merchant Wholesalers; NAICS/Industry Codes: 562111 Solid Waste Collection; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.aca.2004.03.102
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Corton, J. Christopher
AU - Apte, Udayan
AU - Anderson, Steven P.
AU - Limaye, Pallavi
AU - Yoon, Lawrence
AU - Latendresse, John
AU - Dunn, Corrie
AU - Everitt, Jeffrey I.
AU - Voss, Kenneth A.
AU - Swanson, Cynthia
AU - Kimbrough, Carie
AU - Wong, Jean S.
AU - Gill, Sarjeet S.
AU - Chandraratna, Roshantha A. S.
AU - Mi-Kyoung Kwak
AU - Kensler, Thomas W.
AU - Stulnig, Thomas M.
AU - Steffensen, Knut R.
AU - Gustafsson, Jan-Åke
AU - Mehendale, Harihara M.
T1 - Mimetics of Caloric Restriction Include Agonists of Lipid-activated Nuclear Receptors.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/10/29/
VL - 279
IS - 44
M3 - Article
SP - 46204
EP - 46212
SN - 00219258
AB - The obesity epidemic in industrialized countries is associated with increases in cardiovascular disease (CVD) and certain types of cancer. In animal models, caloric restriction (CR) suppresses these diseases as well as chemical-induced tissue damage. These beneficial effects of CR overlap with those altered by agonists of nuclear receptors (NR) under control of the fasting-responsive transcriptional co-activator, peroxisome proliferator-activated co-activator 1α (PGC-1α). In a screen for compounds that mimic CR effects in the liver, we found statistically significant overlaps between the CR transcript profile in wild-type mice and the profiles altered by agonists of lipid-activated NR, including peroxisome proliferator-activated receptor α (PPARα), liver X receptor, and their obligate heterodimer partner, retinoid X receptor. The overlapping genes included those involved in CVD (lipid metabolism and inflammation) and cancer (cell fate). Based on this overlap, we hypothesized that some effects of CR are mediated by PPARα. As determined by transcript profiling, 19% of all gene expression changes in wild-type mice were dependent on PPARα, including Cyp4a10 and Cyp4a14, involved in fatty acid ω-oxidation, acute phase response genes, and epidermal growth factor receptor but not increases in PGC-1α. CR protected the livers of wild-type mice from damage induced by thioacetamide, a liver toxicant and hepatocarcinogen. CR protection was lost in PPARα-null mice due to inadequate tissue repair. These results demonstrate that PPARα mediates some of the effects of CR and indicate that a pharmacological approach to mimicking many of the beneficial effects of CR may be possible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW-calorie diet
KW - REDUCING diets
KW - WEIGHT loss
KW - OBESITY
KW - NUCLEAR receptors (Biochemistry)
KW - CELL receptors
KW - LIPIDS
N1 - Accession Number: 16412670; Corton, J. Christopher 1 Apte, Udayan 2 Anderson, Steven P. 3 Limaye, Pallavi 2 Yoon, Lawrence 3 Latendresse, John 4 Dunn, Corrie 5 Everitt, Jeffrey I. 5 Voss, Kenneth A. 6 Swanson, Cynthia 5 Kimbrough, Carie 3 Wong, Jean S. 7 Gill, Sarjeet S. 7 Chandraratna, Roshantha A. S. 8 Mi-Kyoung Kwak 9 Kensler, Thomas W. 9 Stulnig, Thomas M. 10 Steffensen, Knut R. 10 Gustafsson, Jan-Åke 10 Mehendale, Harihara M. 2; Email Address: mehendale@ulm.edu; Affiliation: 1: ToxicoGenomics, Chapel Hill, North Carolina 27514 2: Department of Toxicology, College of Pharmacy, University of Louisiana, Monroe, Louisiana 71209 3: Department of Safety Assessment, GlaxoSmithKline, Research & Development, Research Triangle Park North Carolina 27709 4: Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas 72079 5: CIIT Centers for Health Research, Research Triangle Park North Carolina 27709 6: Toxicology & Mycotoxin Research Unit, United States Department of Agriculture, Agricultural Research Service, Athens, Georgia 30604 7: Environmental Toxicology Graduate Program, Department of Cell Biology and Neuroscience, University of California, Riverside, California 92521 8: Departments of Chemistry and Biology, Retinoid Research, Allergan Inc., Irvine, California 92612 9: Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205 10: Departments of BioSciences and Medical Nutrition, Novum, Karolinska Institute, 5-14186 Huddinge, Sweden; Source Info: 10/29/2004, Vol. 279 Issue 44, p46204; Subject Term: LOW-calorie diet; Subject Term: REDUCING diets; Subject Term: WEIGHT loss; Subject Term: OBESITY; Subject Term: NUCLEAR receptors (Biochemistry); Subject Term: CELL receptors; Subject Term: LIPIDS; Number of Pages: 9p; Illustrations: 4 Color Photographs, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1074/jbc.M406739200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Byun, Myung-Woo
AU - Ahn, Hyun-Joo
AU - Kim, Jae-Hyun
AU - Lee, Ju-Woon
AU - Yook, Hong-Sun
AU - Han, Sang-Bae
T1 - Determination of volatile N-nitrosamines in irradiated fermented sausage by gas chromatography coupled to a thermal energy analyzer
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2004/10/29/
VL - 1054
IS - 1/2
M3 - Article
SP - 403
EP - 407
SN - 00219673
AB - Volatile N-nitrosodimethylamine (NDMA) and N-nitrosopyrrolidine (NPYR) in irradiated pepperoni and salami sausages were determined using a gas chromatography coupled to a thermal energy analyzer (GC–TEA). These fermented sausages with aerobic or vacuum packaging were irradiated at 0, 5, 10, and 20kGy, and then stored for 4 weeks at 4°C. Both NDMA and NPYR in the fermented sausage were significantly reduced by irradiation. The vacuum packaging showed significantly lower (P < 0.05) N-nitrosamine levels than that of the aerobic ones. After storage, the contents of NDMA and NPYR in the irradiated sausage were lower than those of the non-irradiated control. Results indicated that a high dose of irradiation (>10kGy) was needed to reduce the carcinogenic N-nitrosamines in the fermented sausage during storage and the GC–TEA analysis was effective in determining the N-nitrosamines in irradiated meats even at low trace levels. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Irradiation
KW - Gas chromatography
KW - Nitrosoamines
KW - Sausages
KW - Nitrosamines
KW - Thermal energy analyzer
N1 - Accession Number: 14716447; Byun, Myung-Woo; Email Address: mwbyun@kaeri.re.kr; Ahn, Hyun-Joo 1; Kim, Jae-Hyun 1; Lee, Ju-Woon 1; Yook, Hong-Sun 2; Han, Sang-Bae 3; Affiliations: 1: Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-353, South Korea; 2: Department of Food and Nutrition, Chungnam National University, Daejeon 305-764, South Korea; 3: Division of Food Standards, Korea Food and Drug Administration, Seoul 122-704, South Korea; Issue Info: Oct2004, Vol. 1054 Issue 1/2, p403; Thesaurus Term: Irradiation; Thesaurus Term: Gas chromatography; Subject Term: Nitrosoamines; Subject Term: Sausages; Author-Supplied Keyword: Nitrosamines; Author-Supplied Keyword: Thermal energy analyzer; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.chroma.2004.07.096
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Macher, Abe
AU - Kibble, Deborah
AU - Schuster-Walker, Marmie
T1 - Issues in Correctional HIV Care: Pneumocystis Pneumonia and the Immune Reconstitution Inflammatory Syndrome.
JO - American Jails
JF - American Jails
Y1 - 2004/11//Nov/Dec2004
VL - 18
IS - 5
M3 - Article
SP - 37
EP - 39
SN - 10560319
AB - Reports on cases that demonstrate some of the clinical presentations of patients who have developed pneumocystic-pneumonia-associated immune reconstitution inflammatory syndrome. Paradoxical exacerbation of recently treated pneumocystis pneumonia; Paradoxical exacerbation of remotely treated pneumocystic pneumonia; Unmasking of latent pneumocystis disease; Acute respiratory failure following initiation of antiretroviral therapy in a patient treated for pneumocystis pneumonia.
KW - PNEUMOCYSTIS carinii pneumonia
KW - INFLAMMATION
KW - IMMUNOLOGIC diseases
KW - LUNG diseases
KW - PATIENTS
KW - ANTIRETROVIRAL agents
KW - CLINICAL medicine
KW - ADULT respiratory distress syndrome
N1 - Accession Number: 15394499; Macher, Abe 1 Kibble, Deborah 2 Schuster-Walker, Marmie 3; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland 2: Chronic Care Nurse, Prince William-Manassas Regional Adult Detention center in Manassas, Virginia 3: Nursing Supervisor, Prince William-Manassas Regional Adult Detention center in Manassas, Virginia; Source Info: Nov/Dec2004, Vol. 18 Issue 5, p37; Subject Term: PNEUMOCYSTIS carinii pneumonia; Subject Term: INFLAMMATION; Subject Term: IMMUNOLOGIC diseases; Subject Term: LUNG diseases; Subject Term: PATIENTS; Subject Term: ANTIRETROVIRAL agents; Subject Term: CLINICAL medicine; Subject Term: ADULT respiratory distress syndrome; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106492360
T1 - CYP3A4 polymorphisms -- potential risk factors for breast and prostate cancer: a HuGE review...this article is also available on the website of the Human Genome Epidemiology Network (http://www.cdc.gov/genomics/hugenet/reviews.htm)
AU - Keshava C
AU - McCanlies EC
AU - Weston A
Y1 - 2004/11//
N1 - Accession Number: 106492360. Language: English. Entry Date: 20050729. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653.
KW - Enzymes
KW - Liver
KW - Genetics
KW - Breast Neoplasms -- Risk Factors
KW - Prostatic Neoplasms -- Risk Factors
KW - Male
KW - Men's Health
KW - Female
KW - Women's Health
KW - Drugs, Prescription -- Metabolism
KW - Liver -- Metabolism
KW - Sex Hormones -- Metabolism
KW - Carcinogens
KW - Menarche
KW - Age of Onset
KW - Prostatic Hypertrophy
KW - Information Resources
SP - 825
EP - 841
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 160
IS - 9
PB - Oxford University Press / USA
AB - The steroid hydroxylase CYP3A4 is the most abundant P-450 enzyme in the human liver, and CYP3A enzymes metabolize more than 50% of prescription drugs. The CYP3A4 gene is expressed in the liver, gut, colon, prostate, and breast. Individual variation in CYP3A4 may play a role in breast and prostate carcinogenesis through modulation of sex hormone metabolite levels. Alternatively, CYP3A4 can metabolically activate exogenous carcinogens. CYP3A4 activity varies widely in humans, and more than 78 DNA sequence polymorphisms are known. These observations prompted the hypothesis that variant CYP3A4 may be involved in breast and prostate cancer. Two epidemiologic studies of breast cancer and five of prostate cancer examined CYP3A4 genotypes. A US study showed that inheritance of CYP3A4*1B correlates with early menarche, a breast cancer risk factor. However, an Australian breast cancer case-control study found no association with CYP3A4*1B. Two Scottish prospective studies showed CYP3A4*1B to be a risk factor for prostate cancer among men with benign prostatic hyperplasia. Three other studies were undertaken in the United States: two were case-only studies and the other was a case-sibling control study. Although results for African Americans were inconsistent, these studies suggested that CYP3A4*1B was associated with markers of advanced disease. These observations support the notion that development of robust, conventional molecular epidemiologic case-control studies to address these questions, including gene-gene and gene-environment interactions, will be timely.
SN - 0002-9262
AD - Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV
U2 - PMID: 15496535.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Folb, Peter I.
AU - Bernatowska, Ewa
AU - Chen, Robert
AU - Clemens, John
AU - Dodoo, Alex N. O.
AU - Ellenberg, Susan S.
AU - Farrington, C. Patrick
AU - John, T. Jacob
AU - Lambert, Paul-Henri
AU - MacDonald, Noni E.
AU - Miller, Elizabeth
AU - Salisbury, David
AU - Schmitt, Heinz-J.
AU - Siegrist, Claire-Anne
AU - Wimalaratne, Omala
T1 - A Global Perspective on Vaccine Safety and Public Health: The Global Advisory Committee on Vaccine Safety.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2004/11//
VL - 94
IS - 11
M3 - Article
SP - 1926
EP - 1931
PB - American Public Health Association
SN - 00900036
AB - Established in 1999, the Global Advisory Committee on Vaccine Safety advises the World Health Organization (WHO) on vaccine-related safety issues and enables WHO to respond promptly, efficiently, and with scientific rigor to issues of vaccine safety with potential global importance. The committee also assesses the implications of vaccine safety for practice worldwide and for WHO policies. We describe the principles on which the committee was established, its modus operandi, and the scope of the work undertaken, both present and future. We highlight its recent recommendations on major issues, including the purported link between the measles--mumps--rubella vaccine and autism and the safety of the mumps, influenza, yellow fever, BCG, and smallpox vaccines as well as that of thiomersal-containing vaccines. (Am J Public Health. 2004;94:1926-1931). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMITTEES
KW - ASSOCIATIONS, institutions, etc.
KW - SAFETY
KW - VACCINES
KW - WORLD Health Organization
N1 - Accession Number: 14898920; Folb, Peter I. 1; Email Address: pfolb@mrc.ac.za Bernatowska, Ewa 2 Chen, Robert 3 Clemens, John 4 Dodoo, Alex N. O. 5 Ellenberg, Susan S. 6 Farrington, C. Patrick 7 John, T. Jacob 8 Lambert, Paul-Henri 9 MacDonald, Noni E. 10 Miller, Elizabeth 11 Salisbury, David 12 Schmitt, Heinz-J. 13 Siegrist, Claire-Anne 9 Wimalaratne, Omala 14; Affiliation: 1: Medical Research Council, Cape Town, South Africa 2: Department of Immunology, Children's Memorial Health Institute, Warsaw, Poland 3: Immunization Safety Branch, Centers for Disease Control and Prevention, Atlanta, Ga. 4: International Vaccine Institute, Seoul, Korea 5: Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Accra 6: Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, Maryland 7: Department of Statistics, Open University, Milton Keynes, England 8: Kerala State Institute of Virology and Infectious Diseases, Vellore, India 9: World Health Organization Collaborating Centre for Neonatal Vaccinology, Centre Médical Universitaire, Geneva, Switzerland 10: Department of Paediatrics, Dalhousie University, Halifax, Nova Scotia, Canada 11: Immunisation Department, Health Protection Agency, London, England 12: Communicable Disease and Immunisation Team, Department of Health, London 13: Center for Preventive Pediatrics, Johannes Gutenberg-Universität, Mainz, Germany 14: Department of Rabies and Vaccines, Medical Research Institute, Colombo, Sri Lanka; Source Info: Nov2004, Vol. 94 Issue 11, p1926; Subject Term: COMMITTEES; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: SAFETY; Subject Term: VACCINES; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 4940
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeske, Daniel R.
AU - Blessinger, Todd
T1 - Tunable Approximations for the Mean and Variance of the Maximum of Heterogeneous Geometrically Distributed Random Variables.
JO - American Statistician
JF - American Statistician
Y1 - 2004/11//
VL - 58
IS - 4
M3 - Article
SP - 322
EP - 327
SN - 15372731
AB - Analysis of the maximum of n independent geometrically distributed random variables arises in a variety of applications in computer science and engineering. Evaluating the mean and variance of the maximum when n is large presents considerable computational challenges. Although approximate formulas have been proposed in the case where each geometric distribution has the same probability of success, the heterogeneous case has not received any attention. We derive an epsilon-accurate approximation for both the mean and the variance in the heterogeneous case. The approximations also apply to the homogeneous case, and offer something new with their ability to tune the approximation to any desired level of accuracy. We illustrate the formulas with a reliability application where the heterogeneous context arose quite naturally. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Statistician is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANDOM variables
KW - VARIABLES (Mathematics)
KW - PROBABILITY theory
KW - APPROXIMATION theory
KW - VARIANCES
KW - STATISTICS
KW - Expected value
KW - Extreme value
KW - Negative binomial
KW - System throughput
N1 - Accession Number: 14912465; Jeske, Daniel R. 1; Email Address: daniel.jeske@ucr.edu Blessinger, Todd 2; Affiliation: 1: Associate Professor, Department of Statistics, University of California, Riverside, CA 92521 2: Research Statistician, Food and Drug Administration, Rockville, MD 20855; Source Info: Nov2004, Vol. 58 Issue 4, p322; Subject Term: RANDOM variables; Subject Term: VARIABLES (Mathematics); Subject Term: PROBABILITY theory; Subject Term: APPROXIMATION theory; Subject Term: VARIANCES; Subject Term: STATISTICS; Author-Supplied Keyword: Expected value; Author-Supplied Keyword: Extreme value; Author-Supplied Keyword: Negative binomial; Author-Supplied Keyword: System throughput; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1198/000313004X5509
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106582473
T1 - Ask an expert. Some tips on getting funding for health services research.
AU - Hughes RG
A2 - Stone PW
Y1 - 2004/11//2004 Nov
N1 - Accession Number: 106582473. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8901557.
KW - Grants
KW - Health Services Research
KW - Research Support
KW - Research Priorities
KW - United States Agency for Healthcare Research and Quality
SP - 305
EP - 307
JO - Applied Nursing Research
JF - Applied Nursing Research
JA - APPL NURS RES
VL - 17
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0897-1897
AD - Center for Primary Care, Prevention, & Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; rhughes@ahrq.gov
U2 - PMID: 15573341.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106596323
T1 - Damage of office supply, personal use items, and over-the-counter medical devices after sterilization by ethylene oxide gas, electron beam, and gamma radiation.
AU - Lucas AD
AU - Merritt K
AU - Hitchins VM
AU - Lucas, Anne D
AU - Merritt, Katharine
AU - Hitchins, Victoria M
Y1 - 2004/11//Nov/Dec2004
N1 - Accession Number: 106596323. Language: English. Entry Date: 20050318. Revision Date: 20161117. Publication Type: journal article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Equipment and Supplies
KW - Sterilization and Disinfection -- Methods
KW - Office Management
KW - Mail
KW - Gamma Rays
KW - Ethylene Oxide
KW - Electrons
KW - Biosensing Techniques
KW - Comparative Studies
KW - Human
SP - 476
EP - 484
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 38
IS - 6
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - After letters containing Bacillus anthracis spores entered the U.S. mail in 2001, a problem emerged regarding how to decontaminate the letters, packages, and personal items in offices that received these letters. The effects of three sterilization methods (i.e. ethylene oxide gas [EO], electron beam [e-beam] radiation, and gamma radiation) were evaluated for a variety of office supply and equipment, personal use items, and over-the-counter medical devices. No single sterilization method was suitable for all items that could be mailed or found in an office. Damage or discoloration was evident for some items by each sterilization method. There were changes in the color of certain items, such as some of the packaging material, some pacifiers, some of the fabrics, and the nylon stockings after e-beam and gamma radiation. Both e-beam and gamma radiation damaged all film samples. Following EO sterilization and normal aeration, there were a number of samples with high (above 250 microg/g) levels of EO and samples with detectable ethylene chlorohydrin levels. The data would suggest that certain items exposed to EO sterilization must be further aerated prior to use, or discarded. Generic descriptions of products (such as plastics) or grouping of items (such as condoms) were not sufficient to predict what is safe in terms of EO residual levels remaining on an item. Successful decontamination of a wide variety of items will require careful selection of different sterilization methods.
SN - 0899-8205
AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD, USA
AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD; adl@cdrh.fda.gov
U2 - PMID: 15635999.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sergeev, Nikolay
AU - Distler, Margaret
AU - Courtney, Shannon
AU - Al-Khaldi, Sufian F.
AU - Volokhov, Dmitriy
AU - Chizhikov, Vladimir
AU - Rasooly, Avraham
T1 - Multipathogen oligonucleotide microarray for environmental and biodefense applications
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2004/11//
VL - 20
IS - 4
M3 - Article
SP - 684
EP - 698
SN - 09565663
AB - Food-borne pathogens are a major health problem. The large and diverse number of microbial pathogens and their virulence factors has fueled interest in technologies capable of detecting multiple pathogens and multiple virulence factors simultaneously. Some of these pathogens and their toxins have potential use as bioweapons. DNA microarray technology allows the simultaneous analysis of thousands of sequences of DNA in a relatively short time, making it appropriate for biodefense and for public health uses. This paper describes methods for using DNA microarrays to detect and analyze microbial pathogens. The FDA-1 microarray was developed for the simultaneous detection of several food-borne pathogens and their virulence factors including Listeria spp., Campylobacter spp., Staphylococcus aureus enterotoxin genes and Clostridium perfringens toxin genes. Three elements were incorporated to increase confidence in the microarray detection system: redundancy of genes, redundancy of oligonucleotide probes (oligoprobes) for a specific gene, and quality control oligoprobes to monitor array spotting and target DNA hybridization. These elements enhance the reliability of detection and reduce the chance of erroneous results due to the genetic variability of microbes or technical problems with the microarray. The results presented demonstrate the potential of oligonucleotide microarrays for detection of environmental and biodefense relevant microbial pathogens. [Copyright &y& Elsevier]
AB - Copyright of Biosensors & Bioelectronics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - GENES
KW - HEREDITY
KW - QUALITY of products
KW - TOXINS
KW - COMMERCIAL products -- Testing
KW - FACTORY management
KW - INDUSTRIAL engineering
KW - PROCESS control
KW - Microbial pathogens
KW - Oligonucleotide microarray
N1 - Accession Number: 14871010; Sergeev, Nikolay 1 Distler, Margaret 2 Courtney, Shannon 2 Al-Khaldi, Sufian F. 3 Volokhov, Dmitriy 4 Chizhikov, Vladimir 4 Rasooly, Avraham; Email Address: rasoslya@mail.nih.gov; Affiliation: 1: FDA Center for Devices and Radiological Health, Silver Spring, MD, USA 2: Joint Institute for Food Safety and Applied Nutrition College Park, MD, USA 3: FDA Center for Food Safety and Applied Nutrition, College Park, MD, USA 4: FDA Center for Biologics Evaluation and Research, Rockville, MD, USA; Source Info: Nov2004, Vol. 20 Issue 4, p684; Subject Term: PATHOGENIC microorganisms; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: QUALITY of products; Subject Term: TOXINS; Subject Term: COMMERCIAL products -- Testing; Subject Term: FACTORY management; Subject Term: INDUSTRIAL engineering; Subject Term: PROCESS control; Author-Supplied Keyword: Microbial pathogens; Author-Supplied Keyword: Oligonucleotide microarray; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.bios.2004.04.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14871010&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Rong-Fu
AU - Chen, Huizhong
AU - Paine, Donald D.
AU - Cerniglia, Carl E.
T1 - Microarray method to monitor 40 intestinal bacterial species in the study of azo dye reduction
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2004/11//
VL - 20
IS - 4
M3 - Article
SP - 699
EP - 705
SN - 09565663
AB - Azo dyes are widely used in dye manufacturing, paper printing, textile industries, and as tattoo pigmentation. Since intestinal and skin bacteria can metabolize certain azo dyes to carcinogenic compounds, many researchers have studied the azoreductases of these bacteria. In this study, we used a microarray method to identify the intestinal bacterial species from cultured fecal samples in Brain Heart Infusion (BHI) broth with or without azo dyes that may be involved in azo dye reduction. The microarray was designed to identify 40 bacterial species that are reported in the literature to be predominant in human feces. Results from this study showed 26–30 species are present in the cultured fecal samples. The representative bacteria were then examined for the azo dye reduction activity. [Copyright &y& Elsevier]
AB - Copyright of Biosensors & Bioelectronics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DYES & dyeing
KW - INDUSTRIAL laws & legislation
KW - FECES
KW - AZO dyes
KW - Azo dye reduction
KW - Human intestinal microflora
KW - Microarray
N1 - Accession Number: 14871011; Wang, Rong-Fu; Email Address: rwang@nctr.fda.gov Chen, Huizhong 1 Paine, Donald D. 1 Cerniglia, Carl E. 1; Affiliation: 1: Microbiology Division, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Nov2004, Vol. 20 Issue 4, p699; Subject Term: DYES & dyeing; Subject Term: INDUSTRIAL laws & legislation; Subject Term: FECES; Subject Term: AZO dyes; Author-Supplied Keyword: Azo dye reduction; Author-Supplied Keyword: Human intestinal microflora; Author-Supplied Keyword: Microarray; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bios.2004.04.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Panicker, Gitika
AU - Vickery, Michael C.L.
AU - Bej, Asim K.
T1 - Multiplex PCR detection of clinical and environmental strains of Vibrio vulnificus in shellfish.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2004/11//
VL - 50
IS - 11
M3 - Article
SP - 911
EP - 922
PB - Canadian Science Publishing
SN - 00084166
AB - In this study, we developed a PCR-based rapid detection method for clinically important pathogenic strains of Vibrio vulnificus. Positive amplification of the 504-bp viuB fragment was seen in all 22 clinical isolates tested but only in 8 out of 33 environmental isolates. The combination of the species-specific 205-bp vvh fragment along with viuB in a multiplexed PCR enabled us to confirm the presence of potentially pathogenic strains of V. vulnificus. No amplification of other Vibrio spp. or non-Vibrio bacteria was evidenced, suggesting a high specificity of detection by this method. The sensitivity of detection for both targeted genes was 10 pg of purified DNA, which correlated with 103V. vulnificus CFU in 1 mL of pure culture or 1 g un-enriched seeded oyster tissue homogenate. This sensitivity was improved to 1 CFU per gram of oyster tissue homogenate in overnight-enriched samples. A SYBR Green I based real-time PCR method was also developed that was shown to produce results consistent with the conventional PCR method. Application of the multiplexed real-time PCR to natural oyster tissue homogenates exhibited positive detection of vvh in 51% of the samples collected primarily during the summer months; however, only 15% of vvh positive samples exhibited viuB amplicons. The rapid, sensitive, and specific detection of clinically important pathogenic V. vulnificus in shellfish would be beneficial in reducing illnesses and deaths caused by this pathogen. (English) [ABSTRACT FROM AUTHOR]
AB - Dans cette étude, nous avons conçu une méthode rapide basée sur le PCR pour la détection de souches pathogènes cliniquement importantes de Vibrio vulnificus. Une amplification positive du fragment de 504 pb de viuB a été décelée chez les 22 isolats cliniques analysés mais seulement chez 8 des 33 isolats environnementaux. La combinaison du fragment vvh de 205 pb spécifique à l'espèce avec viuB dans un PCR multiplex nous a permis de confirmer la présence de souches potentiellement pathogènes de V. vulnificus. Nous n'avons pas détecté d'amplification d'autres espèces de Vibrio ou d'autres bactéries, ce qui souligne la spécificité élevée de détection par cette méthode. La sensibilité de détection des deux gènes cibles était de 10 pg d'ADN purifié, ce qui corrélait avec 103 ufc de V. vulnificus dans 1 mL de culture pure ou 1 g d'homogénat de tissus d'huître ensemencée non-enrichi. Cette sensibilité a été améliorée jusqu'à 1 ufc par g d'homogénat de tissus d'huître dans des échantillons enrichis pendant 18 heures. Une méthode de PCR en temps réel basé sur le SYBR-Green I a également été conçue et a généré des résultats qui s'accordaient avec la méthode conventionnelle de PCR. Une application du PCR multiplex en temps réel à des homogénats de tissus d'huîtres naturels a permis la détection positive de vvh dans 51 % des échantillons, recueillis principalement pendant les mois d'été; toutefois, seulement 15 % des échantillons positifs pour vvh démontraient des amplicons viuB. La détection rapide, sensible et spécifique de V. vulnificus pathogènes cliniquement importants chez les mollusques et les crustacés serait utile afin de minimiser des maladies et des pertes causées par ce pathogène. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO vulnificus
KW - PATHOGENIC microorganisms
KW - BACTERIA
KW - SHELLFISH
KW - AQUATIC invertebrates
KW - DNA
KW - NUCLEIC acids
KW - multiplex PCR
KW - real-time PCR.
KW - shellfish
KW - SYBR Green I
KW - Vibrio
KW - mollusques et crustacés
KW - PCR en temps réel
KW - PCR multiplex
N1 - Accession Number: 17956134; Panicker, Gitika 1,2 Vickery, Michael C.L. 1,3 Bej, Asim K. 1; Email Address: abej@uab.edu; Affiliation: 1: Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294-1170, USA. 2: Centers for Disease Control and Prevention, HPV Section, MS G-41, 1600 Clifton Road, Atlanta, GA 30333, USA. 3: US Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville, P.O. Box 158, Dauphin Island, AL 36528, USA.; Source Info: Nov2004, Vol. 50 Issue 11, p911; Subject Term: VIBRIO vulnificus; Subject Term: PATHOGENIC microorganisms; Subject Term: BACTERIA; Subject Term: SHELLFISH; Subject Term: AQUATIC invertebrates; Subject Term: DNA; Subject Term: NUCLEIC acids; Author-Supplied Keyword: multiplex PCR; Author-Supplied Keyword: real-time PCR.; Author-Supplied Keyword: shellfish; Author-Supplied Keyword: SYBR Green I; Author-Supplied Keyword: Vibrio; Author-Supplied Keyword: mollusques et crustacés; Author-Supplied Keyword: PCR en temps réel; Author-Supplied Keyword: PCR multiplex; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 12p; Document Type: Article
L3 - 10.1139/W04-085
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, F.
T1 - Arresting NF-?B byß-arrestin2.
JO - Cell Death & Differentiation
JF - Cell Death & Differentiation
Y1 - 2004/11//
VL - 11
IS - 11
M3 - Article
SP - 1155
EP - 1156
PB - Nature Publishing Group
SN - 13509047
AB - The article focuses on the activity of NF-kappa B, a ubiquitous transcription factor governing the expression of genes involved in various cellular functions during both normal physiological conditions and pathological circumstances. A number of endogenous inhibitors that restrict the activation or activity of NF-kappa B have been identified recently, in addition to I-kappa B family proteins. The reputation of NF-kappa B is notorious because of its involvement in inflammatory and/or carcinogenic diseases in human beings. Therefore, inhibition of NF-kappa B may slow down disease processes. A new endogenous inhibitor, β-arrestin2, that blocks signal-induced I-kappa Bα degradation and subsequent activation of NF-kappa B transcription factor. β-arrestin2 is ubiquitously expressed in virtually all types of cells, where it interacts with seven-membrane-spanning receptors after their phosphorylation by G-protein-coupled receptor kinases.
KW - NF-kappa B (DNA-binding protein)
KW - TRANSCRIPTION factors
KW - CELLULAR control mechanisms
KW - CELL interaction (Biology)
KW - CELLULAR pathology
KW - CELLULAR signal transduction
N1 - Accession Number: 14733627; Chen, F. 1; Affiliation: 1: Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Nov2004, Vol. 11 Issue 11, p1155; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: TRANSCRIPTION factors; Subject Term: CELLULAR control mechanisms; Subject Term: CELL interaction (Biology); Subject Term: CELLULAR pathology; Subject Term: CELLULAR signal transduction; Number of Pages: 2p; Document Type: Article
L3 - 10.1038/sj.cdd.4401496
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sen, Goutam
AU - Flora, Michael
AU - Chattopadhyay, Gouri
AU - Klinman, Dennis M.
AU - Lees, Andrew
AU - Mond, James J.
AU - Snapper, Clifford M.
T1 - The critical DNA flanking sequences of a CpG oligodeoxynucleotide, but not the 6 base CpG motif, can be replaced with RNA without quantitative or qualitative changes in Toll-like receptor 9-mediated activity
JO - Cellular Immunology
JF - Cellular Immunology
Y1 - 2004/11//
VL - 232
IS - 1/2
M3 - Article
SP - 64
EP - 74
SN - 00088749
AB - Abstract: Double- and single-stranded oligodeoxynucleotides containing unmethylated cytosine–guanosine (CpG) dinucleotides (CpG-ODN) activate immune cells via TLR9. In this report we synthesized hybrid DNA–RNA molecules (HDR) in order to further explore the structure–immune function relationship of CpG-ODN in TLR9 signaling and the potential immunomodulatory properties of RNA. We demonstrate that replacement of the deoxyadenosine flanking sequences, critical for the immune activating properties of CpG-ODN, with a similar number of adenosines, although not guanosines, cytosines, or uracils, maintains complete immunostimulatory activity of the hybrid oligonucleotide in vitro, whereas a similar RNA replacement of even 1 base of the required unmethylated 6 base DNA motif (purine–purine–CpG–pyrimidine–pyrimidine) results in a complete loss of activity. Regardless of whether the critical flanking sequence was RNA or DNA there was no significant change in the quantitative or qualitative immune-stimulating activity, or TLR-specificity of the resulting sequences, thus underscoring the relatively permissive functional role of the flanking sequence, and the more specific role of the motif in mediating TLR9 signaling. These data further support a potential role for RNA in immunomodulation. [Copyright &y& Elsevier]
AB - Copyright of Cellular Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDES
KW - IMMUNOLOGICAL adjuvants
KW - IMMUNE response -- Regulation
KW - ADENINE
KW - Adjuvant
KW - CpG
KW - DNA
KW - Humoral immunity
KW - Oligonucleotides
KW - RNA
N1 - Accession Number: 17856002; Sen, Goutam 1 Flora, Michael 1 Chattopadhyay, Gouri 1 Klinman, Dennis M. 2 Lees, Andrew 3 Mond, James J. 3 Snapper, Clifford M. 1; Email Address: csnapper@usuhs.mil; Affiliation: 1: Institute for Vaccine Research, Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Biosynexus Inc. Rockville, MD 20850, USA; Source Info: Nov2004, Vol. 232 Issue 1/2, p64; Subject Term: NUCLEOTIDES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: IMMUNE response -- Regulation; Subject Term: ADENINE; Author-Supplied Keyword: Adjuvant; Author-Supplied Keyword: CpG; Author-Supplied Keyword: DNA; Author-Supplied Keyword: Humoral immunity; Author-Supplied Keyword: Oligonucleotides; Author-Supplied Keyword: RNA; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.cellimm.2005.01.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106487305
T1 - Primary care update: brief summaries for clinical practice. Nutrition and physical fitness web sites: a 4-star guide on where to look and what to look for.
AU - Whyte JJ
AU - Marting RN
Y1 - 2004/11//2004 Nov
N1 - Accession Number: 106487305. Language: English. Entry Date: 20050715. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110.
KW - Nutrition
KW - Physical Fitness
KW - Information Resources
KW - World Wide Web
SP - 1684
EP - 1687
JO - Consultant (00107069)
JF - Consultant (00107069)
JA - CONSULTANT
VL - 44
IS - 13
CY - Framingham, Massachusetts
PB - United Business Media
SN - 0010-7069
AD - Medical Advisor, US Department of Health and Human Services (USDHHS/Agency for Healthcare Research), Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pan, Yuan T.
AU - Koroth Edavana, Vineetha
AU - Jourdian, William J.
AU - Edmondson, Rick
AU - Carroll, J. David
AU - Pastuszak, Irena
AU - Elbein, Alan D.
T1 - Trehalose synthase ofMycobacterium smegmatis.
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
Y1 - 2004/11//
VL - 271
IS - 21
M3 - Article
SP - 4259
EP - 4269
PB - Wiley-Blackwell
SN - 00142956
AB - Trehalose synthase (TreS) catalyzes the reversible interconversion of trehalose (glucosyl-α,α-1,1-glucose) and maltose (glucosyl-α1-4-glucose). TreS was purified from the cytosol ofMycobacterium smegmatisto give a single protein band on SDS gels with a molecular mass of≈ 68 kDa. However, active enzyme exhibited a molecular mass of≈ 390 kDa by gel filtration suggesting that TreS is a hexamer of six identical subunits. Based on amino acid compositions of several peptides, thetreSgene was identified in theM. smegmatisgenome sequence, and was cloned and expressed in active form inEscherichia coli.The recombinant protein was synthesized with a (His)6 tag at the amino terminus. The interconversion of trehalose and maltose by the purified TreS was studied at various concentrations of maltose or trehalose. At a maltose concentration of 0.5 mm, an equilibrium mixture containing equal amounts of trehalose and maltose (42–45% of each) was reached during an incubation of about 6 h, whereas at 2 mmmaltose, it took about 22 h to reach the same equilibrium. However, when trehalose was the substrate at either 0.5 or 2 mm, only about 30% of the trehalose was converted to maltose in≥ 12 h, indicating that maltose is the preferred substrate. These incubations also produced up to 8–10% free glucose. TheKm for maltose was≈ 10 mm, whereas for trehalose it was≈ 90 mm. Whileβ,β-trehalose, isomaltose (α1,6-glucose disaccharide), kojibiose (α1,2) or cellobiose (β1,4) were not substrates for TreS, nigerose (α1,3-glucose disaccharide) andα,β-trehalose were utilized at 20 and 15%, respectively, as compared to maltose. The enzyme has a pH optimum of about 7 and is inhibited in a competitive manner by Tris buffer.[3H]Trehalose is converted to[3H]maltose even in the presence of a 100-fold or more excess of unlabeled maltose, and[14C]maltose produces[14C]trehalose in excess unlabeled trehalose, suggesting the possibility of separate binding sites for maltose and trehalose. The catalytic mechanism may involve scission of the incoming disaccharide and transfer of a glucose to an enzyme-bound glucose, as[3H]glucose incubated with TreS and either unlabeled maltose or trehalose results in formation of[3H]disaccharide. TreS also catalyzes production of a glucosamine disaccharide from maltose and glucosamine, suggesting that this enzyme may be valuable in carbohydrate synthetic chemistry. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCOSE
KW - MALTOSE
KW - CYTOSOL
KW - ENZYMES
KW - AMINO acids
KW - MOLECULAR weights
KW - maltose
KW - Mycobacteria
KW - sugar interconversions
KW - trehalose biosynthesis
KW - trehalose metabolism.
N1 - Accession Number: 14848755; Pan, Yuan T. 1 Koroth Edavana, Vineetha 1 Jourdian, William J. 2 Edmondson, Rick 3 Carroll, J. David 4 Pastuszak, Irena 1 Elbein, Alan D. 1; Email Address: elbeinaland@uams.edu; Affiliation: 1: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. 2: Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Ml, USA. 3: National Center for Toxicological Research, Jefferson, AR, USA. 4: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Source Info: Nov2004, Vol. 271 Issue 21, p4259; Subject Term: GLUCOSE; Subject Term: MALTOSE; Subject Term: CYTOSOL; Subject Term: ENZYMES; Subject Term: AMINO acids; Subject Term: MOLECULAR weights; Author-Supplied Keyword: maltose; Author-Supplied Keyword: Mycobacteria; Author-Supplied Keyword: sugar interconversions; Author-Supplied Keyword: trehalose biosynthesis; Author-Supplied Keyword: trehalose metabolism.; Number of Pages: 11p; Document Type: Article
L3 - 10.1111/j.1432-1033.2004.04365.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sedegah, M.
AU - Charoenvit, Y.
AU - Aguiar, J.
AU - Sacci, J.
AU - Hedstrom, R.
AU - Kumar, S.
AU - Belmonte, A.
AU - Lanar, D. E.
AU - Jones, T. R.
AU - Abot, E.
AU - Druilhe, P.
AU - Corradin, G.
AU - Epstein, J. E.
AU - Richie, T. L.
AU - Carucci, D. J.
AU - Hoffman, S. L.
T1 - Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF.
JO - Genes & Immunity
JF - Genes & Immunity
Y1 - 2004/11//
VL - 5
IS - 7
M3 - Article
SP - 553
EP - 561
PB - Nature Publishing Group
SN - 14664879
AB - One potential benefit of DNA vaccines is the capacity to elicit antibody and T-cell responses against multiple antigens at the same time by mixing plasmids expressing different proteins. A possible negative effect of such mixing is interference among plasmids regarding immunogenicity. In preparation for a clinical trial, we assessed the immunogenicity of GMP-produced plasmids encoding five Plasmodium falciparum proteins, PfCSP, PfSSP2, PfEXP1, PfLSA1, and PfLSA3, given as a mixture, or alone. The mixture induced higher levels of antibodies against whole parasites than did the individual plasmids, but was associated with a decrease in antibodies to individual P. falciparum proteins. T-cell responses were in general decreased by administration of the mixture. Immune responses to individual plasmids and mixtures were generally higher in inbred mice than in outbreds. In inbred BALB/c and C57BL/6 mice, coadministration of a plasmid expressing murine granulocyte-macrophage colony-stimulating factor (mGM-CSF), increased antibody and T-cell responses, but in outbred CD-1 mice, coadministration of mGM-CSF was associated with a decrease in antibody responses. Such variability in data from studies in different strains of mice underscores the importance of genetic background on immune response and carefully considering the goals of any preclinical studies of vaccine mixtures planned for human trials.Genes and Immunity (2004) 5, 553-561. doi:10.1038/sj.gene.6364125 Published online 19 August 2004 [ABSTRACT FROM AUTHOR]
AB - Copyright of Genes & Immunity is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA vaccines
KW - T cells
KW - LYMPHOCYTES
KW - MALARIA
KW - PLASMIDS
KW - VACCINATION
KW - IMMUNE response
KW - malaria
KW - T lymphocytes
KW - vaccination
N1 - Accession Number: 14815817; Sedegah, M. 1 Charoenvit, Y. 1 Aguiar, J. 1 Sacci, J. 1,2 Hedstrom, R. 1,3 Kumar, S. 1,4 Belmonte, A. 1 Lanar, D. E. 5 Jones, T. R. 1 Abot, E. 1 Druilhe, P. 6 Corradin, G. 7 Epstein, J. E. 1 Richie, T. L. 1 Carucci, D. J. 1 Hoffman, S. L. 1,8; Email Address: slhoffman@sanaria.com; Affiliation: 1: Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA 2: Department of Microbiology, The University of Maryland School of Medicine, Baltimore, MD, USA 3: DynPort Vaccine Company LLC, Frederick, MD, USA 4: CBER, Food and Drug Administration, Rockville, MD, USA 5: Walter Reed Army Institute of Research, Silver Spring, MD, USA 6: Parasitologie Biomedicale, Institut Pasteur, France 7: Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland 8: Sanaria Inc., 12111 Parklawn Drive, Rockville, MD 20852, USA; Source Info: Nov2004, Vol. 5 Issue 7, p553; Subject Term: DNA vaccines; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: MALARIA; Subject Term: PLASMIDS; Subject Term: VACCINATION; Subject Term: IMMUNE response; Author-Supplied Keyword: malaria; Author-Supplied Keyword: T lymphocytes; Author-Supplied Keyword: vaccination; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1038/sj.gene.6364125
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Weschler, Charles J.
AU - Wells, Ray
T1 - Guest Editorial.
JO - Indoor Air
JF - Indoor Air
Y1 - 2004/11//
VL - 14
IS - 6
M3 - Editorial
SP - 373
EP - 375
PB - Wiley-Blackwell
SN - 09056947
AB - Offers information on the Indoor Chemistry and Health workshop, conducted by the U.S. National Institute for Occupational Safety and Health at the University of California in Santa Cruz on July 12 to 15, 2004. Purpose of the workshop; Highlights of the event; Research priorities and hypothesis relevant to the field of indoor chemistry.
KW - INDOOR air pollution
KW - WORKSHOPS (Adult education)
KW - INDUSTRIAL safety
KW - SEMINARS
KW - CHEMISTRY
KW - CALIFORNIA
N1 - Accession Number: 14797966; Weschler, Charles J. 1,2 Wells, Ray 3; Affiliation: 1: International Centre for Indoor Environment and Energy, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark 2: Environmental and Occupational Health Sciences Institute, University of Medicine & Dentistry of NJ & Rutgers University, Piscataway,NJ 08854,USA 3: National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Exposure Assessment Branch, Morgantown, WV 26505, USA; Source Info: Nov2004, Vol. 14 Issue 6, p373; Subject Term: INDOOR air pollution; Subject Term: WORKSHOPS (Adult education); Subject Term: INDUSTRIAL safety; Subject Term: SEMINARS; Subject Term: CHEMISTRY; Subject Term: CALIFORNIA; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1111/j.1600-0668.2004.00321.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, J.- H.
AU - Schleiff, P. L.
AU - Attfield, M. D.
AU - Cox-Ganser, J. M.
AU - Kreiss, K.
T1 - Building-related respiratory symptoms can be predicted with semi-quantitative indices of exposure to dampness and mold.
JO - Indoor Air
JF - Indoor Air
Y1 - 2004/11//
VL - 14
IS - 6
M3 - Article
SP - 425
EP - 433
PB - Wiley-Blackwell
SN - 09056947
AB - Using a semi-quantitative mold exposure index, the National Institute for Occupational Safety and Health (NIOSH) investigated 13 college buildings to examine whether building-related respiratory symptoms among employees are associated with environmental exposure to mold and dampness in buildings. We collected data on upper and lower respiratory symptoms and their building-relatedness, and time spent in specific rooms with a self-administered questionnaires. Trained NIOSH industrial hygienists classified rooms for water stains, visible mold, mold odor, and moisture using semi-quantitative scales and then estimated individual exposure indices weighted by the time spent in specific rooms. The semi-quantitative exposure indices significantly predicted building-related respiratory symptoms, including wheeze [odds ratio (OR) = 2.3; 95% confidence interval (CI) = 1.1–4.5], chest tightness (OR = 2.2; 95% CI = 1.1–4.6), shortness of breath (OR = 2.7; 95% CI = 1.2–6.1), nasal (OR = 2.5; 95% CI = 1.3–4.7) and sinus (OR = 2.2; 95% CI = 1.2–4.1) symptoms, with exposure–response relationships. We found that conditions suggestive of indoor mold exposure at work were associated with building-related respiratory symptoms. Our findings suggest that observational semi-quantitative indices of exposure to dampness and mold can support action to prevent building-related respiratory diseases. Current air sampling methods have major limitations in assessing exposure to mold and other biological agents that may prevent the demonstration of associations of bioaerosol exposure with health. Our study demonstrates that semi-quantitative dampness/mold exposure indices, based solely on visual and olfactory observation and weighted by time spent in specific rooms, can predict existence of excessive building-related respiratory symptoms and diseases. Relative extent of water stains, visible mold, mold odor, or moisture can be used to prioritize remediation to reduce potential risk of building-related respiratory diseases. From a public health perspective, these observational findings justify action to correct water leaks and repair water damage in order to prevent building-related respiratory diseases. This approach can also be a basis for developing practical building-diagnostic tools for water-incursion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - INDOOR air pollution
KW - SICK building syndrome
KW - DAMPNESS in buildings
KW - MOLDS (Fungi)
KW - Building
KW - Dampness
KW - Indoor air quality
KW - Mold
KW - Respiratory symptoms
KW - Semi-quantitative exposure index
N1 - Accession Number: 14797968; Park, J.- H. 1; Email Address: gzp8@cdc.gov Schleiff, P. L. 1 Attfield, M. D. 1 Cox-Ganser, J. M. 1 Kreiss, K. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, Morgantown, WV, USA; Source Info: Nov2004, Vol. 14 Issue 6, p425; Subject Term: RESPIRATORY diseases; Subject Term: INDOOR air pollution; Subject Term: SICK building syndrome; Subject Term: DAMPNESS in buildings; Subject Term: MOLDS (Fungi); Author-Supplied Keyword: Building; Author-Supplied Keyword: Dampness; Author-Supplied Keyword: Indoor air quality; Author-Supplied Keyword: Mold; Author-Supplied Keyword: Respiratory symptoms; Author-Supplied Keyword: Semi-quantitative exposure index; Number of Pages: 9p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2004.00291.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allread, W.Gary
AU - Wilkins III, J.R.
AU - Marras, William S.
AU - Waters, Thomas R.
T1 - Physical Demands and Low-Back Injury Risk Among Children and Adolescents Working on Farms.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2004/11//
VL - 10
IS - 4
M3 - Article
SP - 257
EP - 273
SN - 10747583
AB - Discusses a study on the risk of musculoskeletal disorders among youths who perform physically demanding farm activities. Use of the lumbar motion monitor to record trunk movements while performing routine manual material handling tasks; Association of high injury risk jobs in industrial workplaces; Quantification of physical demands of tasks performed on farms.
KW - Materials handling
KW - Farms
KW - Wounds & injuries
KW - Musculoskeletal emergencies
KW - Youth
KW - Work environment
KW - Farming
KW - Manual material handling
KW - Musculoskeletal disorders
KW - Spine loading
N1 - Accession Number: 15324769; Allread, W.Gary 1; Email Address: allread.1@osu.edu; Wilkins III, J.R. 2; Marras, William S. 3; Waters, Thomas R. 4; Affiliations: 1: Program Director, Institute for Ergonomics, The Ohio State University, Columbus, Ohio; 2: Professor and Chair, Division of Epidemiology and Biostatistics, School of Public Health, The Ohio State University, Columbus, Ohio; 3: Honda Professor and Director, Biodynamics Laboratory, Institute for Ergonomics, The Ohio State University, Columbus, Ohio; 4: Chief of Human Factors and Ergonomics Research Section, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Nov2004, Vol. 10 Issue 4, p257; Thesaurus Term: Materials handling; Thesaurus Term: Farms; Thesaurus Term: Wounds & injuries; Subject Term: Musculoskeletal emergencies; Subject Term: Youth; Subject Term: Work environment; Author-Supplied Keyword: Farming; Author-Supplied Keyword: Manual material handling; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Spine loading; Number of Pages: 17p; Illustrations: 8 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rader, Jeanne I.
AU - Weaver, Carol M.
AU - Trucksess, Mary W.
T1 - Extension of AOAC Official Method 999.14 (Choline in Infant Formula and Milk) to the Determination of Choline in Dietary Supplements.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1297
EP - 1304
SN - 10603271
AB - Reports on a standard method to determine choline in milk and infant formulas, including dietary supplements. Extension of the standard curve to cover a wider range of choline concentrations; Interference of the vitamin C content with the analysis; Inclusion of an alkaline digestion for use with a product containing lecithin as the sole source of choline.
KW - CHOLINE
KW - INFANT formulas
KW - DIETARY supplements
KW - PHYSICAL & theoretical chemistry
KW - EXTRACTION (Chemistry)
KW - DIGESTION
N1 - Accession Number: 15627988; Rader, Jeanne I. 1; Email Address: Jeanne.Rader@cfsan.fda.gov Weaver, Carol M. 1 Trucksess, Mary W. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1297; Subject Term: CHOLINE; Subject Term: INFANT formulas; Subject Term: DIETARY supplements; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: EXTRACTION (Chemistry); Subject Term: DIGESTION; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 8p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chase Jr., G. William
AU - Lin Ye
AU - Stoakes, Vicky C.
AU - Eitenmiller, Ronald R.
AU - Long, Austin R.
T1 - Interlaboratory Verified Liquid Chromatographic Method for Analysis of Vitamins A and E in Soy-Based Infant Formula Powder.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1329
EP - 1333
SN - 10603271
AB - Presents an interlaboratory verified, chromatographic method for the analysis of vitamin A and E in soy-based infant formula powder. Procedures for extraction; Procurement of the reference material; Analysis of the fortified samples.
KW - ANALYTICAL chemistry
KW - DRUGS
KW - VITAMIN A
KW - VITAMIN E
KW - INFANT formulas
KW - SOYBEAN
N1 - Accession Number: 15627993; Chase Jr., G. William 1; Email Address: wchase@ora.fda.gov Lin Ye 2 Stoakes, Vicky C. 1 Eitenmiller, Ronald R. 1 Long, Austin R. 1; Affiliation: 1: U.S. Food and Drug Administration, Atlanta Center for Nutrient Analysis, 60 Eighth St, Atlanta, GA 30309 2: University of Georgia, Department of Food Science and Technology, Athens, GA 30602; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1329; Subject Term: ANALYTICAL chemistry; Subject Term: DRUGS; Subject Term: VITAMIN A; Subject Term: VITAMIN E; Subject Term: INFANT formulas; Subject Term: SOYBEAN; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 111110 Soybean Farming; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Kristina M.
T1 - Methodological Aspects of Food Allergens.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1380
EP - 1381
SN - 10603271
AB - Comments on the importance of accurate detection methods for food allergens for the food industry. Prevalence of hypersensitive response to food allergens; Influence of the change in population demographics; Benefit of the labeling of commercial products.
KW - ALLERGENS
KW - ANTIGENS
KW - COMMERCIAL products
KW - FOOD industry
KW - MANUFACTURES
KW - PRODUCT management
N1 - Accession Number: 15627998; Williams, Kristina M. 1; Email Address: kwillia2@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Immunobiology Branch, 8301 Muirkirk Rd, Laurel, MD 20708; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1380; Subject Term: ALLERGENS; Subject Term: ANTIGENS; Subject Term: COMMERCIAL products; Subject Term: FOOD industry; Subject Term: MANUFACTURES; Subject Term: PRODUCT management; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 339999 All Other Miscellaneous Manufacturing; NAICS/Industry Codes: 339990 All other miscellaneous manufacturing; Number of Pages: 3p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gendel, Steven M.
T1 - Bioinformatics and Food Allergens.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1417
EP - 1422
SN - 10603271
AB - Reports on the importance of bioinformatics in the improvement of technology for the detection of food allergens. Development of allergen specific databases; Improvement of methods for data mining; Examples of existing allergen databases.
KW - BIOINFORMATICS
KW - INFORMATION science
KW - ALLERGENS
KW - FOOD adulteration & inspection
KW - PUBLIC health
KW - CONSUMERS
N1 - Accession Number: 15628003; Gendel, Steven M. 1; Email Address: sgendel@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Rd, Summit-Argo, IL 60501; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1417; Subject Term: BIOINFORMATICS; Subject Term: INFORMATION science; Subject Term: ALLERGENS; Subject Term: FOOD adulteration & inspection; Subject Term: PUBLIC health; Subject Term: CONSUMERS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 6p; Illustrations: 5 Black and White Photographs, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Westphal, Carmen D.
AU - Raybourne, Richard B.
T1 - Potential Allergenicity of Novel Proteins in Murine Models.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1433
EP - 1440
SN - 10603271
AB - Reports on the importance of bioengineered crops to farmers who want to avoid losses caused by insect infestations or adverse environmental conditions. Concern of the public on the safety of bioengineered foods; Expression of the potential allergenicity of proteins by the newly introduced genes; Development of animal models to evaluate novel proteins.
KW - GENETICALLY modified foods
KW - FOOD -- Biotechnology
KW - FARMERS
KW - CROPS
KW - AGRICULTURE
KW - PROTEINS
N1 - Accession Number: 15628005; Westphal, Carmen D. 1; Email Address: carmen.westphal@cfsan.fda.gov Raybourne, Richard B. 1; Affiliation: 1: U.S. Food and Drug Administration, Center of Food Safety and Applied Nutrition, 8301 Muirkirk Rd, Laurel, MD 20708; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1433; Subject Term: GENETICALLY modified foods; Subject Term: FOOD -- Biotechnology; Subject Term: FARMERS; Subject Term: CROPS; Subject Term: AGRICULTURE; Subject Term: PROTEINS; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Westphal, Carmen D.
AU - Pereira, Marion R.
AU - Raybourne, Richard B.
AU - Williams, Kristina M.
T1 - Evaluation of Extraction Buffers Using the Current Approach of Detecting Multiple Allergenic and Nonallergenic Proteins in Food.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1458
EP - 1465
SN - 10603271
AB - Rreports on the challenge of detecting food allergens due to the need to ensure the absence of undeclared allergens in foods. Difference of commercial kits in their ability to detect allergens; Standardization of the detection methods; Use of a peanut butter suspension as a reference material.
KW - ALLERGENS
KW - ANTIGENS
KW - FOOD
KW - QUALITY control
KW - SPECIFICATIONS
KW - PEANUT products
N1 - Accession Number: 15628008; Westphal, Carmen D. 1; Email Address: carmen.westphal@cfsan.fda.gov Pereira, Marion R. 1 Raybourne, Richard B. 1 Williams, Kristina M. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Rd, Laurel, MD 20708; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1458; Subject Term: ALLERGENS; Subject Term: ANTIGENS; Subject Term: FOOD; Subject Term: QUALITY control; Subject Term: SPECIFICATIONS; Subject Term: PEANUT products; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; Number of Pages: 8p; Illustrations: 6 Black and White Photographs, 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Kristina M.
AU - Westphal, Carmen D.
AU - Shriver-Lake, Lisa C.
T1 - Determination of Egg Proteins in Snack Food and Noodles.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2004/11//Nov/Dec2004
VL - 87
IS - 6
M3 - Article
SP - 1485
EP - 1491
SN - 10603271
AB - Reports on the control of food allergic responses by avoidance of the offending foods. Application of a commercial enzyme-linked immunosorbent assay kit for the detection of egg in food products; Evaluation of an antibody-based biosensor; Examination of the performance of the Veratox for Egg Allergen Test kit from Neogen Corp.
KW - ALLERGENS
KW - FOOD
KW - FOOD industry
KW - ENZYME-linked immunosorbent assay
KW - DETECTORS
KW - PROTEINS
N1 - Accession Number: 15628012; Williams, Kristina M. 1; Email Address: kwillia2@cfsan.fda.gov Westphal, Carmen D. 1 Shriver-Lake, Lisa C. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708 2: Center for Bio/Molecular Science and Engineering, Code 6920, Naval Research Laboratory, 4555 Overlook Avenue, SW, Washington, DC 20375; Source Info: Nov/Dec2004, Vol. 87 Issue 6, p1485; Subject Term: ALLERGENS; Subject Term: FOOD; Subject Term: FOOD industry; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: DETECTORS; Subject Term: PROTEINS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, P.I.
AU - Bai, H.
AU - Bai, D.
AU - Chae, H.
AU - Chung, S.
AU - Kim, V.
AU - Park, R.
AU - Chi, V.-T.
T1 - Purification and characterization of a lipopeptide produced byBacillus thuringiensisCMB26.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2004/11//
VL - 97
IS - 5
M3 - Article
SP - 942
EP - 949
PB - Wiley-Blackwell
SN - 13645072
AB - p.i. kim, h. bai, d. bai, h. chae, s. chung, y. kim, r. park and y.-t. chi. 2004.To isolate an antagonist for use in the biological control of phytopathogenic fungi includingColletotrichum gloeosporioides, then to purify and characterize the biocontrol agent produced by the antagonist.Bacteria that exhibited antifungal activity against the causative agent pepper anthracnose were isolated from soil, withBacillus thuringiensisCMB26 showing the strongest activity. A lipopeptide produced byB. thuringiensisCMB26 was precipitated by adjusting the pH 2 with 3 nHCl and extracted using chloroform/methanol (2 : 1, v/v) and reversed-phase HPLC. The molecular weight was estimated as 1447 Da by MALDI-TOF mass spectrometry. Scanning electron and optical microscopies showed that the lipopeptide has activity againstEscherichia coliO157:ac88, larvae of the cabbage white butterfly (Pieris rapae crucivora) and phytopathogenic fungi. The lipopeptide had cyclic structure and the amino acid composition wasl-Glu,d-Orn,l-Tyr,d-allo-Thr,d-Ala,d-Val,l-Pro, andl-Ile in a molar ratio of 3 : 1 : 2 : 1 : 1 : 2 : 1 : 1. The purified lipopeptide showed the same amino acid composition as fengycin, but differed slightly in fatty acid composition, in which the double bond was at carbons 13–14 (m/z303, 316) and there was no methyl group.A lipopeptide was purified and characterized fromB. thuringiensisCMB26 and found to be similar to the lipopeptide fengycin. This lipopeptide can function as a biocontrol agent, and exhibits fungicidal, bactericidal, and insecticidal activity.Compared with surfactin and iturin, the lipopeptide fromB. thuringiensisCMB26 showed stronger antifungal activity against phytopathogenic fungi. This lipopeptide is a candidate for the biocontrol of pathogens in agriculture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacillus thuringiensis
KW - Phytopathogenic fungi
KW - Antifungal agents
KW - Microbiology
KW - Microbial peptides
KW - Colletotrichum gloeosporioides
KW - Bacillus thuringiensis CMB26
KW - biocontrol agent
KW - fengycin
KW - Golletotriclium gloeosporioides
KW - lipopeptide
N1 - Accession Number: 14621690; Kim, P.I. 1; Bai, H. 2; Bai, D. 3; Chae, H. 3; Chung, S. 4; Kim, V. 5; Park, R. 2; Chi, V.-T. 3; Email Address: ytchi@chonnam.chonnam.ac.kr; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 2: Division of Appiled Bioscience and Biotechnology; 3: School of Biological Sciences and Technology and Biotechnology Research Institute; 4: Division of Applied Plant Science, Chonnam National University, Gwangju, Korea; 5: Proteome Analysis Team, Korea Basic Science Institute, Daejeon, Korea; Issue Info: Nov2004, Vol. 97 Issue 5, p942; Thesaurus Term: Bacillus thuringiensis; Thesaurus Term: Phytopathogenic fungi; Thesaurus Term: Antifungal agents; Thesaurus Term: Microbiology; Subject Term: Microbial peptides; Subject Term: Colletotrichum gloeosporioides; Author-Supplied Keyword: Bacillus thuringiensis CMB26; Author-Supplied Keyword: biocontrol agent; Author-Supplied Keyword: fengycin; Author-Supplied Keyword: Golletotriclium gloeosporioides; Author-Supplied Keyword: lipopeptide; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1365-2672.2004.02356.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tsai, Chen-An
AU - Chen, James J.
T1 - Significance Analysis of ROC Indices for Comparing Diagnostic Markers: Applications to Gene Microarray Data.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2004/11//
VL - 14
IS - 4
M3 - Article
SP - 985
EP - 1003
PB - Taylor & Francis Ltd
SN - 10543406
AB - A common objective in microarray experiments is to select genes that are differentially expressed between two classes (two treatment groups). Selection of differentially expressed genes involves two steps. The first step is to calculate a discriminatory score that will rank the genes in order of evidence of differential expressions. The second step is to determine a cutoff for the ranked scores. Summary indices of the receiver operating characteristic (ROC) curve provide relative measures for a ranking of differential expressions. This article proposes using the hypothesis-testing approach to compute the raw p-values and/or adjusted p-values for three ROC discrimination measures. A cutoff p-value can be determined from the (ranked) p-values or the adjusted p-values to select differentially expressed genes. To quantify the degree of confidence in the selected top-ranked genes, the conditional false discovery rate (FDR) over the selected gene set and the“Type I” (false positive) error probability for each selected gene are estimated. The proposed approach is applied to a public colon tumor data set for illustration. The selected gene sets from three ROC summary indices and the commonly used two-sample t-statistic are applied to the sample classification to evaluate the predictability of the four discrimination measures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - COLON (Insects)
KW - TUMORS
KW - DISCRIMINATION
KW - ASSIMILATION (Sociology)
KW - WEIGHTS & measures
KW - Colon tumor dataset
KW - False discovery rate (FDR)
KW - Familywise error rate (FWE)
KW - Number of true null hypotheses
KW - Receiver operating characteristic curve.
N1 - Accession Number: 15332231; Tsai, Chen-An 1 Chen, James J. 1; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.; Source Info: Nov2004, Vol. 14 Issue 4, p985; Subject Term: GENES; Subject Term: COLON (Insects); Subject Term: TUMORS; Subject Term: DISCRIMINATION; Subject Term: ASSIMILATION (Sociology); Subject Term: WEIGHTS & measures; Author-Supplied Keyword: Colon tumor dataset; Author-Supplied Keyword: False discovery rate (FDR); Author-Supplied Keyword: Familywise error rate (FWE); Author-Supplied Keyword: Number of true null hypotheses; Author-Supplied Keyword: Receiver operating characteristic curve.; Number of Pages: 19p; Document Type: Article
L3 - 10.1081/BIP-200035475
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15332231&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Piperova, L. S.
AU - Moallem, U.
AU - Teter, B. B.
AU - Sampugna, J.
AU - Yurawecz, M. P.
AU - Morehouse, K. M.
AU - Luchini, D.
AU - Erdman, R. A.
T1 - Changes in Milk Fat in Response to Dietary Supplementation with Calcium Salts of Trans-18:1 or Conjugated Linoleic Fatty Acids in Lactating Dairy Cows.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2004/11//
VL - 87
IS - 11
M3 - Article
SP - 3836
EP - 3844
SN - 00220302
AB - Milk fat was investigated in lactating dairy cows fed diets supplemented with Ca salts of trans fatty acids (Ca-tFA) or Ca salts of conjugated linoleic acids (Ca-CLA). Forty-five Holstein cows (115 days in milk) were fed a control diet (51% forage; dry matter basis) supplemented with 400 g of EnerG II (Ca salts of palm oil fatty acids) for 2 wk; subsequently, 5 groups of 9 cows each were assigned for 4 wk to the control diet or diets containing 100 g of Ca-CLA or 100, 200, or 400 g of Ca-tFA in a randomized block design. Treatments had no effect on dry matter intake, milk production, protein, lactose, or somatic cell count. Milk fat percentage was reduced from 3.39% in controls to 3.30, 3.04, and 2.98%, respectively, by the Ca-tFA diets and to 2.54% by the Ca-CLA diet. Milk fat yield (1.24 kg/d in controls) was decreased by 60, 130, and 190 g/d with increasing dose of Ca-tFA and by 290 g/d with the Ca-CLA supplement. Consistent with increased endogenous synthesis of cis9-containing CLA from precursors provided by the Ca-tFA diets, total CLA were similar in milk of cows fed Ca-CLA or Ca-tFA. Compared with controls, the Ca-CLA diet increased trans-10, cis-12-18:2 yield in milk, without altering levels of trans-18:1 isomers. In contrast, yields of most trans-18:1 isomers were elevated in milk of cows fed Ca-tFA diets, whereas yields of trans-10, cis-12-18:2 remained similar to control values. We conclude that milk fat depression can occur without an increase in trans-10, cis-12-18:2 in milk and that other components, perhaps the trans-10-18:1 isomer, may be involved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dairy Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fatty acids
KW - Milkfat
KW - Calcium salts
KW - Dairy cattle -- Feeding & feeds
KW - Milk -- Composition
KW - conjugated linoleic acids
KW - lactating cow
KW - trans fatty acids
N1 - Accession Number: 14938959; Piperova, L. S. 1; Moallem, U. 1; Teter, B. B. 1; Sampugna, J. 1; Yurawecz, M. P. 2; Morehouse, K. M. 2; Luchini, D. 3; Erdman, R. A. 1; Email Address: erdman@umd.edu; Affiliations: 1: Animal and Avian Sciences Department, University of Maryland, College Park 20742; 2: Department of Chemistry and Biochemistry, University of Maryland, College Park 20742; 3: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20742; Issue Info: Nov2004, Vol. 87 Issue 11, p3836; Thesaurus Term: Fatty acids; Subject Term: Milkfat; Subject Term: Calcium salts; Subject Term: Dairy cattle -- Feeding & feeds; Subject Term: Milk -- Composition; Author-Supplied Keyword: conjugated linoleic acids; Author-Supplied Keyword: lactating cow; Author-Supplied Keyword: trans fatty acids; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 8 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Tollefson, Linda
AU - Kruse, Hilde
AU - Wegener, Henrik C.
T1 - "Public Health Consequences of Macrolide Use in Food Animals: A Deterministic Risk Assessment," A Comment on: J. Food Prot. 67(5):980-992 (2004).
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/11//
VL - 67
IS - 11
M3 - Letter
SP - 2368
EP - 2369
SN - 0362028X
AB - Presents a letter to the editor in reaction to the article "Public Health Consequences of Macrolide Use in Food Animals: A Deterministic Risk Assessment," which comments on the issue of antimicrobial resistance in foodborne pathogens resulting from the use of antimicrobials in food-producing animals, published in the May 2004 issue of the "Journal of Food Protection."
KW - Letters to the editor
KW - Macrolide antibiotics
N1 - Accession Number: 15115895; Tollefson, Linda 1; Kruse, Hilde 2; Wegener, Henrik C. 3; Affiliations: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland 20855, USA; 2: Norweigan Zoonosis Centre, National Veterinary Institute, Oslo, Norway; 3: Danish Institute of Food and Veterinary Research, Søborg, Denmark; Issue Info: Nov2004, Vol. 67 Issue 11, p2368; Subject Term: Letters to the editor; Subject Term: Macrolide antibiotics; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kaufman, G. E.
AU - Blackstone, G. M.
AU - Vickery, M. C. L.
AU - Bej, A. K.
AU - Bowers, J.
AU - Bowen, Michael D.
AU - Meyer, Richard F.
AU - dePaola, A.
T1 - Real-Time PCR Quantification of Vibrio parahemolyticus in Oysters Using an Alternative Matrix.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/11//
VL - 67
IS - 11
M3 - Article
SP - 2424
EP - 2429
SN - 0362028X
AB - This study examined the relationship between levels of total Vibrio parahaemolyticus found in oyster tissues and mantle fluid with the goal of using mantle fluid as a template matrix in a new quantitative real-time PCR assay targeting the thermolabile hemolysin (tlh) gene for the enumeration of total V. parahaemolyticus in oysters. Oysters were collected near Mobile Bay, Ala., in June, July, and September and tested immediately after collection and storage at 26°C for 24 h. Initial experiments using DNA colony hybridization targeting tlh demonstrated that natural V. parahaemolyticus levels in the mantle fluid of individual oysters were strongly correlated (r = 0.85, P < 0.05) with the levels found in their tissues. When known quantities of cultured V. parahaemolyticus cells were added to real-time PCR reactions that contained mantle fluid and oyster tissue matrices separately pooled from multiple oysters, a strong linear correlation was observed between the real-time PCR cycle threshold and the log concentration of cells inoculated into each PCR reaction (mantle fluid: r = 0.98, P < 0.05; and oyster: r = 0.99, P < 0.05). However, the mantle fluid exhibited less inhibition of the PCR amplification than the homogenized oyster tissue. Analysis of natural V. parahaemolyticus populations in mantle fluids using both colony hybridization and real-time PCR demonstrated a significant (P < 0.05) but reduced correlation (r = −0.48) between the two methods. Reductions in the efficiency of the real-time PCR that resulted from low population densities of V. parahaemolyticus and PCR inhibitors present in the mantle fluid of some oysters (with significant oyster-to-oyster variation) contributed to the reduction in correlation between the methods that was observed when testing natural V. parahaemolyticus populations. The V. parahaemolyticus-specific real-time PCR assay used for this study could estimate elevated V. parahaemolyticus levels in oyster mantle fluid within 1 h from sampling time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters
KW - Marine microbiology
KW - Vibrio parahaemolyticus
KW - Polymerase chain reaction
KW - Mobile Bay (Ala.)
KW - Alabama
N1 - Accession Number: 15115906; Kaufman, G. E. 1; Blackstone, G. M. 1; Vickery, M. C. L. 1,2; Bej, A. K. 1; Bowers, J. 3; Bowen, Michael D. 4; Meyer, Richard F. 4; dePaola, A. 5; Email Address: adepaola@cfsan.fda.gov; Affiliations: 1: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170; 2: Cepheid, Sunnyvale, CA 94089, USA; 3: U.S. Food and Drug Administrative, Office of Math and Statistics, 5100 Paint Branch Parkway, College Park, Maryland 20740; 4: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30333, USA; 5: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, P.O. Box 158, Dauphin Island, Alabama 36528-0158; Issue Info: Nov2004, Vol. 67 Issue 11, p2424; Thesaurus Term: Oysters; Thesaurus Term: Marine microbiology; Subject Term: Vibrio parahaemolyticus; Subject Term: Polymerase chain reaction; Subject Term: Mobile Bay (Ala.); Subject: Alabama; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 6p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yoon, K. S.
AU - Burnette, C. N.
AU - Abou-zeid, K. A.
AU - Whiting, R. C.
T1 - Control of Growth and Survival of Listeria monocytogenes on Smoked Salmon by Combined Potassium Lactate and Sodium Diacetate and Freezing Stress during Refrigeration and Frozen Storage.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/11//
VL - 67
IS - 11
M3 - Article
SP - 2465
EP - 2471
SN - 0362028X
AB - In this study, we evaluated the antimicrobial effects of different levels of a potassium lactate (PL) plus sodium diacetate (SDA) mixture against the growth and survival of Listeria monocytogenes Scott A inoculated onto smoked salmon stored at 4, 10, and −20°C. The effect of freezing stress on the growth kinetics of L. monocytogenes Scott A on smoked salmon at 4 and 10°C was also investigated. The use of PL+SDA at all tested levels (1.5, 3.3, and 5% of a 60% commercial solution of PURASAL P Opti.Form 4) completely inhibited the growth of L. monocytogenes Scott A on smoked salmon stored at 4°C during 32 days of storage. It also delayed the growth of L. monocytogenes Scott A on smoked salmon stored at 10°C for up to 11 days, but a listeriostatic effect was observed only with 5% PURASAL P Opti.Form 4 at 10°C after 11 days. Addition of PL+SDA at all tested levels decreased the surviving populations of L. monocytogenes Scott A on smoked salmon during 10 months of frozen storage at −20°C. Freezing stress significantly (P < 0.001) extended the lag time and delayed the growth of L. monocytogenes Scott A at both 4 and 10°C. However, the effect of freezing stress was more significant at 4°C than at 10°C, indicating the importance of temperature control of smoked salmon during the retail storage period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial growth
KW - Anti-infective agents
KW - Salmon
KW - Microbiology
KW - Listeria monocytogenes
KW - Food -- Analysis
N1 - Accession Number: 15115912; Yoon, K. S. 1; Email Address: ksyoon@ymes.edu; Burnette, C. N. 1; Abou-zeid, K. A. 1; Whiting, R. C. 2; Affiliations: 1: Center for Food Science and Technology, University of Maryland Eastern Shore, Princess Anne, Maryland 21853; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Nov2004, Vol. 67 Issue 11, p2465; Thesaurus Term: Bacterial growth; Thesaurus Term: Anti-infective agents; Thesaurus Term: Salmon; Thesaurus Term: Microbiology; Subject Term: Listeria monocytogenes; Subject Term: Food -- Analysis; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 7p; Illustrations: 5 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rodriguez-Saona, L. E.
AU - Khambaty, F. M.
AU - Fry, F. S.
AU - Dubois, J.
AU - Calvey, E. M.
T1 - Detection and Identification of Bacteria in a Juice Matrix with Fourier Transform-Near Infrared Spectroscopy and Multivariate Analysis.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2004/11//
VL - 67
IS - 11
M3 - Article
SP - 2555
EP - 2559
SN - 0362028X
AB - The use of Fourier transform-near infrared (FT-NIR) spectroscopy combined with multivariate pattern recognition techniques was evaluated to address the need for a fast and sensitive method for the detection of bacterial contamination in liquids. The complex cellular composition of bacteria produces FT-NIR vibrational transitions (overtone and combination bands), forming the basis for identification and subtyping. A database including strains of Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Bacillus cereus, and Bacillus thuringiensis was built, with special care taken to optimize sample preparation. The bacterial cells were treated with 70% (vol/vol) ethanol to enhance safe handling of pathogenic strains and then concentrated on an aluminum oxide membrane to obtain a thin bacterial film. This simple membrane filtration procedure generated reproducible FT-NIR spectra that allowed for the rapid discrimination among closely related strains. Principal component analysis and soft independent modeling of class analogy of transformed spectra in the region 5,100 to 4,400 cm-1 were able to discriminate between bacterial species. Spectroscopic analysis of apple juices inoculated with different strains of E. coli at approximately 105 CFU/ml showed that FT-NIR spectral features are consistent with bacterial contamination and soft independent modeling of class analogy correctly predicted the identity of the contaminant as strains of E. coli. FT-NIR in conjunction with multivariate techniques can be used for the rapid and accurate evaluation of potential bacterial contamination in liquids with minimal sample manipulation, and hence limited exposure of the laboratory worker to the agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Liquids
KW - Escherichia coli
KW - Bacteriology
KW - Classification of bacteria
KW - Fourier transform infrared spectroscopy
N1 - Accession Number: 15115924; Rodriguez-Saona, L. E. 1,2,3; Khambaty, F. M. 2; Fry, F. S. 2; Dubois, J. 1; Calvey, E. M. 2; Email Address: elizabeth.calvey@cfsan.fda.gov; Affiliations: 1: Joint Institute for Food Safety and Applied Nutrition (JIFSAN) - University of Maryland, College Park, Maryland 20742; 2: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; 3: Food Science and Technology Department, The Ohio State University, 110 Parker Food Science and Technology Building, 2015 Fyffe Road, Columbus, OH 43210, USA; Issue Info: Nov2004, Vol. 67 Issue 11, p2555; Thesaurus Term: Liquids; Thesaurus Term: Escherichia coli; Thesaurus Term: Bacteriology; Subject Term: Classification of bacteria; Subject Term: Fourier transform infrared spectroscopy; Number of Pages: 5p; Illustrations: 4 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106535280
T1 - Characteristics of children who have full or incomplete fetal alcohol syndrome.
AU - Kvigne VL
AU - Leonardson GR
AU - Neff-Smith M
AU - Brock E
AU - Borzelleca J
AU - Welty TK
Y1 - 2004/11//2004 Nov
N1 - Accession Number: 106535280. Language: English. Entry Date: 20051104. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: The Indian Health Service (IHS); the Centers for Disease Control and Prevention. NLM UID: 0375410.
KW - Fetal Alcohol Syndrome
KW - Native Americans
KW - Abnormalities
KW - Birth Order
KW - Case Control Studies
KW - Central Nervous System Diseases -- Etiology
KW - Chi Square Test
KW - Child Development Disorders
KW - Confidence Intervals
KW - Female
KW - Fetal Alcohol Syndrome -- Complications
KW - Fetal Alcohol Syndrome -- Ethnology
KW - Fetal Alcohol Syndrome -- Symptoms
KW - Foster Home Care
KW - Funding Source
KW - Hospitalization
KW - Infant, Newborn
KW - Male
KW - McNemar's Test
KW - Odds Ratio
KW - Pregnancy
KW - Record Review
KW - Retrospective Design
KW - T-Tests
KW - United States
KW - Human
SP - 635
EP - 640
JO - Journal of Pediatrics
JF - Journal of Pediatrics
JA - J PEDIATR
VL - 145
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0022-3476
AD - Aberdeen Area Indian Health Service, PHS Indian Hospital, Rapid City, South Dakota
U2 - PMID: 15520764.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106587703
T1 - Evolution of a child health profile initiative.
AU - Linzer DS
AU - Lloyd-Puryear MA
AU - Mann M
AU - Kogan MD
Y1 - 2004/11//Nov/Dec2004
N1 - Accession Number: 106587703. Language: English. Entry Date: 20050304. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Child Health
KW - Genetic Screening -- In Infancy and Childhood
KW - Health Information Systems
KW - Infant, Newborn, Diseases -- Prevention and Control
KW - Systems Integration
KW - Government Agencies
KW - Health Policy
KW - Infant, Newborn
KW - Informatics
KW - Private Sector
KW - Program Development
KW - Public Health Administration
KW - Public Sector
KW - State Health Plans
SP - S16
EP - 23
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 10
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - While information technology has proliferated and advanced dramatically in the last 10 years, the application of information technology to health care policy and delivery has not been well coordinated either among public health agencies or between the public and private health sectors. In 1998, the Genetic Services Branch, Division of Services for Children with Special Health Needs, Maternal and Child Health Bureau, Health Resources and Services Administration (HRSA/MCHB) began an initiative to help facilitate assessment and prompt provision of appropriate services to improve the health of children. Twenty-five state public health programs received grants to improve integration of newborn screening and genetic services systems with other maternal and child health systems. All Kids Count-a program of the Public Health Informatics Institute-completed a qualitative assessment of state programs that were funded to develop plans for integration. The results are being translated into a business/policy case addressing the need for integration, a description of essential functions that such systems support, ultimately system requirements, and measures for evaluation. HRSA/MCHB's partnership with All Kids Count continues with a project to develop a community of practice to assist programs in moving their integrated child health information systems forward.
SN - 1078-4659
AD - Genetic Services Branch, DSCSHN/MCHB/HRSA, Room 18A-19, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; dlinzer@hrsa.gov
U2 - PMID: 15643353.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hawkshaw, Mary J.
AU - Anticaglia, Joseph
AU - Sataloff, Robert T.
T1 - The Effects of Smoking on Voice Performance.
JO - Journal of Singing
JF - Journal of Singing
Y1 - 2004/11//Nov/Dec2004
VL - 61
IS - 2
M3 - Article
SP - 167
EP - 171
SN - 10867732
AB - Investigates the effects of smoking on voice performance. Effect of tobacco smoking on the mucosal covering of the vocal folds; Significance of the lungs on the power of the vocal tract; Possible causes of dysphonia; Ways of protecting the larynx; Chemical additives found in tobacco; Parts of the anatomy responsible for articulation.
KW - SMOKING
KW - ORAL habits
KW - TOBACCO use
KW - VOICE
KW - MUSIC -- Physiological aspects
KW - THROAT
N1 - Accession Number: 15150098; Hawkshaw, Mary J. 1; Anticaglia, Joseph 2; Sataloff, Robert T.; Affiliations: 1 : Member in the Society of Otolaryngologic Head and Neck Nurses (SOHN); 2 : Chief Medical Officer in the United States Public Health Service; Source Info: Nov/Dec2004, Vol. 61 Issue 2, p167; Subject Term: SMOKING; Subject Term: ORAL habits; Subject Term: TOBACCO use; Subject Term: VOICE; Subject Term: MUSIC -- Physiological aspects; Subject Term: THROAT; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - mah
ER -
TY -
AU - Hassol, Andrea1, andreahassol@abtassoc.com
AU - Walker, James M.2
AU - Kidder, David1
AU - Rokita, Kim2
AU - Young, David2
AU - Pierdon, Steven2
AU - Deitz, Deborah1
AU - Kuck, Sarah1
AU - Ortiz, Eduardo3
T1 - Patient Experiences and Attitudes about Access to a Patient Electronic Health Care Record and Linked Web Messaging.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2004/11//Nov/Dec2004
Y1 - 2004/11//Nov/Dec2004
VL - 11
IS - 6
CP - 6
M3 - Article
SP - 505
EP - 513
SN - 10675027
AB - Objective: Patient access to their electronic health care record (EHR) and Web-based communication between patients and providers can potentially improve the quality of health care, but little is known about patients' attitudes toward this combined electronic access. The objective of our study was to evaluate patients' values and perceptions regarding Web-based communication with their primary care providers in the context of access to their electronic health care record. Methods: We conducted an online survey of 4,282 members of the Geisinger Health System who are registered users of an application (MyChart) that allows patients to communicate electronically with their providers and view selected portions of their EHR. To supplement the survey, we also conducted focus groups with 25 patients who were using the system and conducted one-on-one interviews with ten primary care clinicians. We collected and analyzed data on user satisfaction, ease of use, communication preferences, and the completeness and accuracy of the patient EHR. Results: A total of 4,282 registered patient EHR users were invited to participate in the survey; 1,421 users (33%) completed the survey, 60% of them female. The age distribution of users was as follows: 18 to 30 (5%), 31 to 45 (24%), 46 to 64 (54%), 65 and older (16%). Using a continuous scale from 1 to 100, the majority of users indicated that the system was easy to use (mean scores ranged from 78 to 85) and that their medical record information was complete, accurate, and understandable (mean scores ranged from 65 to 85). Only a minority of users was concerned about the confidentiality of their information or about seeing abnormal test results after receiving only an explanatory electronic message from their provider. Patients preferred e-mail communication for some interactions (e.g., requesting prescription renewals, obtaining general medical information), whereas they preferred in-person communication for others (e.g., getting... [ABSTRACT FROM AUTHOR]
KW - Medical records -- Access control
KW - Medical informatics
KW - Perception
KW - Patients
KW - Medical care -- Quality control
N1 - Accession Number: 15136952; Authors: Hassol, Andrea 1 Email Address: andreahassol@abtassoc.com; Walker, James M. 2; Kidder, David 1; Rokita, Kim 2; Young, David 2; Pierdon, Steven 2; Deitz, Deborah 1; Kuck, Sarah 1; Ortiz, Eduardo 3; Affiliations: 1: Abt Associates Inc., Cambridge, MA; 2: Geisinger Health System, Danville, PA; 3: Agency for Healthcare Research and Quality and VA Medical Center, Washington, DC; Subject: Perception; Subject: Patients; Subject: Medical records -- Access control; Subject: Medical informatics; Subject: Medical care -- Quality control; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Record Type: Article
L3 - 10.1197/jamia.M1593
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Nicolaysen, P. H.
AU - Klink, K. J.
AU - Shriver, E.
AU - Knutsen, G.
AU - Hubbs, A. F.
AU - Depree, G. J.
AU - Siegel, P. D.
AU - Weissman, D. N.
AU - Whitmer, M.
AU - Meade, B. Jean
T1 - Local and Systemic Toxicity in Mice Following Subcutaneous Implantation of Latex Penrose Drains.
JO - Journal of Toxicology -- Cutaneous & Ocular Toxicology
JF - Journal of Toxicology -- Cutaneous & Ocular Toxicology
Y1 - 2004/11//
VL - 23
IS - 4
M3 - Article
SP - 233
EP - 248
PB - Taylor & Francis Ltd
SN - 07313829
AB - Penrose drains are widely used in surgical procedures as an aid in wound healing. The studies presented here investigated the potential toxicity associated with the implantation of latex Penrose drains in BALB/c and B6C3F1 mice. Animals were implanted subcutaneously in the dorsal surface of the neck with 100, 150, or 200 mg of Perry latex drain or 200 mg of Bard(comparative control) latex drain for up to 36 hours. High-dose(200 mg) exposure to the Perry drain induced severe local and systemic toxicity, resulting in mortality within 24 hours. Time- and dose-responsive effects included decreased response to stimulus, inflammation at the implantation site, epaxial myositis, lesions consistent with hepatic glycogen depletion, apoptotic necrosis of the adrenal“X zone,” and massive thymic apoptosis and atrophy. Negligible levels of endotoxin were quantified from Perry drain samples using the Limulus Amebocyte Lysate Assay. Extraction studies revealed the presence of zinc diethyldithiocarbamate(ZDEC) in the Perry drains but not in the control drains. No other differences were noted from gas chromatography mass spectrometry(GCMS) analyses. Quantitation studies measured ZDEC levels at 2.22 ± 0.04µg/mg in Perry samples. When ZDEC was eluted from Perry drains prior to implantation, animals exhibited no signs of toxicity. Although FDA regulations limit accelerators to 1.5% of rubber medical products, these studies indicate that the presence of ZDEC in concentrations lower than 0.25% of the drain weight may induce local toxicity and delayed wound healing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Surgical drainage
KW - Latex
KW - Rubber
KW - Artificial implants
KW - Latex Penrose drains
KW - Subcutaneous implantation
KW - Systemic toxicity
KW - Zinc diethyldithiocarbamate
N1 - Accession Number: 15244744; Nicolaysen, P. H. 1; Klink, K. J. 1; Shriver, E. 1; Knutsen, G. 1; Hubbs, A. F. 1; Depree, G. J. 1; Siegel, P. D. 1; Weissman, D. N. 1; Whitmer, M. 1; Meade, B. Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: M/S L4020, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Nov2004, Vol. 23 Issue 4, p233; Thesaurus Term: Toxicology; Subject Term: Surgical drainage; Subject Term: Latex; Subject Term: Rubber; Subject Term: Artificial implants; Author-Supplied Keyword: Latex Penrose drains; Author-Supplied Keyword: Subcutaneous implantation; Author-Supplied Keyword: Systemic toxicity; Author-Supplied Keyword: Zinc diethyldithiocarbamate; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; Number of Pages: 16p; Illustrations: 1 Black and White Photograph, 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1081/CUS-200036691
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15244744&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fairley, Kimberly J.
AU - Howell, Michael D.
AU - Tomazic-Jezic, Vesna J.
AU - Leakakos, Tina
AU - Truscott, Wava
AU - Meade, B. Jean
T1 - Augmented Latex-Specific IGE Antibody Response in BALB/c Mice Upon Concurrent Exposure to Natural Rubber Latex Proteins with Glutaraldehyde.
JO - Journal of Toxicology -- Cutaneous & Ocular Toxicology
JF - Journal of Toxicology -- Cutaneous & Ocular Toxicology
Y1 - 2004/11//
VL - 23
IS - 4
M3 - Article
SP - 303
EP - 320
PB - Taylor & Francis Ltd
SN - 07313829
AB - Health care workers are exposed to numerous agents that are known to induce hypersensitivity-mediated diseases. Yet, little is known regarding the role of coexposure to these agents on the development of hypersensitivity responses. The present studies were conducted to evaluate the immunomodulatory role of dermal exposure to glutaraldehyde(Glut) on the induction of IgE antibodies to natural rubber latex(NRL) proteins. Female BALB/c mice were dermally exposed to Glut(0.05–1 ppm; 0.1–1%) and nonammoniated latex(NAL; 25µg) 5 days/week for up to 86 days. The NAL alone at concentrations up to 1% did not induce significantly elevated levels of total serum or latex specific IgE. In contrast, both total and NAL-specific serum IgE were dose-dependently(p < 0.01 and p < 0.05, respectively) elevated in mice concurrently exposed to 25µg NAL and increasing concentrations of Glut up to 0.75 ppm. Further testing was performed to investigate the mechanism by which Glut augmented the latex-specific response. Barrier integrity tests demonstrated that Glut did not induce sufficient disruption of the strateum corneum(less than 1% 3H20 penetration was observed in a guinea pig model) to allow for increased penetration of the latex proteins. However, co-exposure to 25µg NAL and 0.75 ppm Glut for 2 days as compared to the vehicle control was shown to induce a 15-fold increase in MHC II positive Langerhans'cells in the epidermis. Additional experiments confirmed the upregulation of a Th2 response. Upon sacrifice following 86 days of exposure, animals exposed to 25µg NAL and 0.75 ppm Glut demonstrated a significant increase(p < 0.01) in CD40 +(3.95 ± 0.38 × 106), B220 +(7.67 ± 1.18 × 106), and IgE + B220 +(3.28 ± 0.75 × 106) cells as compared to the vehicle control groups(2.29 ± 0.18 × 106, 3.31 ± 0.18 × 106, and 0.82 ± 0.15 × 106 cells), respectively. These studies demonstrate the potential for mixed exposures in the health care environment to modulate the development of IgE mediated responses to natural rubber latex proteins, underscoring the importance of environmental factors in the development of allergies to foreign antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology -- Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Proteins
KW - Latex
KW - Immunoglobulin E
KW - Medical personnel
KW - Glutaraldehyde
KW - IgE
KW - Latex proteins
N1 - Accession Number: 15244739; Fairley, Kimberly J. 1; Howell, Michael D. 1; Tomazic-Jezic, Vesna J. 2; Leakakos, Tina 3; Truscott, Wava 4; Meade, B. Jean 1; Email Address: bhm8@cdc.gov; Affiliations: 1: Agriculture and Immunotoxicology Group, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: The Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA; 3: Preclinical Development, FeRX Inc., San Diego, California, USA; 4: Scientific Affairs and Clinical Education, Kimberly-Clark Corporation, Roswell, Georgia, USA; Issue Info: Nov2004, Vol. 23 Issue 4, p303; Thesaurus Term: Allergy; Subject Term: Proteins; Subject Term: Latex; Subject Term: Immunoglobulin E; Subject Term: Medical personnel; Author-Supplied Keyword: Glutaraldehyde; Author-Supplied Keyword: IgE; Author-Supplied Keyword: Latex proteins; Number of Pages: 18p; Illustrations: 1 Black and White Photograph, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1081/CUS-200037220
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cohen, Jeffrey I.
AU - Cox, Edward
AU - Pesnicak, Lesley
AU - Srinivas, Shamala
AU - Krogmann, Tammy
T1 - The Varicella-Zoster Virus Open Reading Frame 63 Latency-Associated Protein Is Critical for Establishment of Latency.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/11//
VL - 78
IS - 21
M3 - Article
SP - 11833
EP - 11840
SN - 0022538X
AB - Varicella-zoster virus (VZV) expresses at least six viral transcripts during latency. One of these transcripts, derived from open reading frame 63 (ORF63), is one of the most abundant viral RNAs expressed during latency. The VZV ORF63 protein has been detected in human and experimentally infected rodent ganglia by several laboratories. We have deleted >90% of both copies of the ORF63 gene from the VZV genome. Animals inoculated with the ORF63 mutant virus had lower mean copy numbers of latent VZV genomes in the dorsal root ganglia 5 to 6 weeks after infection than animals inoculated with parental or rescued virus, and the frequency of latently infected animals was significantly lower in animals infected with the ORF63 mutant virus than in animals inoculated with parental or rescued virus. In contrast, the frequency of animals latently infected with viral mutants in other genes that are equally or more impaired for replication in vitro, compared with the ORF63 mutant, is similar to that of animals latently infected with parental VZV. Examination of dorsal root ganglia 3 days after infection showed high levels of VZV DNA in animals infected with either ORF63 mutant or parental virus; however, by days 6 and 10 after infection, the level of viral DNA in animals infected with the ORF63 mutant was significantly lower than that in animals infected with parental virus. Thus, ORF63 is not required for VZV to enter ganglia but is the first VZV gene shown to be critical for establishment of latency. Since the present vaccine can reactivate and cause shingles, a VZV vaccine based on the ORF63 mutant virus might be safer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VARICELLA-zoster virus
KW - HERPESVIRUSES
KW - VIRUSES
KW - VIROLOGY
KW - MICROBIOLOGY
KW - MICROORGANISMS
N1 - Accession Number: 14976120; Cohen, Jeffrey I. 1; Email Address: jcohen@niaid.nih.gov Cox, Edward 2 Pesnicak, Lesley 1 Srinivas, Shamala 3 Krogmann, Tammy 1; Affiliation: 1: Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland 2: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 20850 3: Grants Review Branch, National Cancer Institute, Bethesda, MD 20892; Source Info: Nov2004, Vol. 78 Issue 21, p11833; Subject Term: VARICELLA-zoster virus; Subject Term: HERPESVIRUSES; Subject Term: VIRUSES; Subject Term: VIROLOGY; Subject Term: MICROBIOLOGY; Subject Term: MICROORGANISMS; Number of Pages: 8p; Illustrations: 5 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1128/JVI.78.21.11833-11840.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tollefson, Linda
AU - Karp, Beth E.
T1 - Human health impact from antimicrobial use in food animals
T2 - Conséquences sur la santé humaine de l’utilisation d’antibiotiques dans l’alimentation animale
JO - Medecine & Maladies Infectieuses
JF - Medecine & Maladies Infectieuses
Y1 - 2004/11//
VL - 34
IS - 11
M3 - Article
SP - 514
EP - 521
SN - 0399077X
AB - Abstract: There is accumulating evidence that the use of antimicrobials in food-producing animals has adverse human health consequences. The use of antibiotics in food animals selects for resistant pathogens and resistance genes that may be transferred to humans through the consumption or handling of foods of animal origin. Recent studies have demonstrated that antimicrobial-resistance among foodborne bacteria may cause excess cases of illness, prolonged duration of illness, and increased rates of bacteremia, hospitalization, and death. The continued availability of safe and effective antimicrobials for humans and animals depends upon the responsible use of these products. [Copyright &y& Elsevier]
AB - Copyright of Medecine & Maladies Infectieuses is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - ANTIBIOTICS
KW - FOOD of animal origin
KW - BACTERIA
KW - ANIMALS
KW - Antibiotics for animals
KW - Antimicrobial-resistance
KW - Foodborne disease
N1 - Accession Number: 15802384; Tollefson, Linda; Email Address: ltollefs@cvm.fda.gov Karp, Beth E. 1; Affiliation: 1: Center for Veterinary Medicine, US Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, États-Unis; Source Info: Nov2004, Vol. 34 Issue 11, p514; Subject Term: ANTI-infective agents; Subject Term: ANTIBIOTICS; Subject Term: FOOD of animal origin; Subject Term: BACTERIA; Subject Term: ANIMALS; Author-Supplied Keyword: Antibiotics for animals; Author-Supplied Keyword: Antimicrobial-resistance; Author-Supplied Keyword: Foodborne disease; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.medmal.2004.07.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stingley, Robin L.
AU - Brezna, Barbara
AU - Khan, Ashraf A.
AU - Cerniglia, Carl E.
T1 - Novel organization of genes in a phthalate degradation operon of Mycobacterium vanbaalenii PYR-1.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2004/11//
VL - 150
IS - 11
M3 - Article
SP - 3749
EP - 3761
SN - 13500872
AB - Mycobacterium vanbaalenii PYR-1 is capable of degrading polycyclic aromatic hydrocarbons (PAHs) to ring cleavage metabolites. This study identified and characterized a putative phthalate degradation operon in the M. vanbaalenii PYR-1 genome. A putative regulatory protein (phtR) was encoded divergently with five tandem genes: phthalate dioxygenase large subunit (phtAa), small subunit (phtAb), phthalate dihydrodiol dehydrogenase (phtB), phthalate dioxygenase ferredoxin subunit (phtAc) and phthalate dioxygenase ferredoxin reductase (phtAd). A 6-7 kb EcoRI fragment containing these genes was cloned into Escherichia coli and converted phthalate to 3,4-dihydroxyphthalate. Homologues to the operon region were detected in a number of PAH-degrading Mycobacterium spp. isolated from various geographical locations. The operon differs from those of other Gram-positive bacteria in both the placement and orientation of the regulatory gene. In addition, the M. vanbaalenii PYR-1 pht operon contains no decarboxylase gene and none was identified within a 37 kb region containing the operon. This study is the first report of a phthalate degradation operon in Mycobacterium spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbiology (13500872) is the property of Society for General Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Metabolites
KW - Hydrocarbons
KW - Escherichia coli
KW - Gram-positive bacteria
KW - Mycobacterium
KW - Genes
N1 - Accession Number: 15353876; Stingley, Robin L. 1; Brezna, Barbara 1,2; Khan, Ashraf A. 1; Email Address: Ashraf@nctr.fdagov; Cerniglia, Carl E. 1; Affiliations: 1: Division of Microbioiogy, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.; 2: institute of Molecular Biology, Slovak Academy of Sciences. 845 51 Bratislava, Slovakia.; Issue Info: Nov2004, Vol. 150 Issue 11, p3749; Thesaurus Term: Metabolites; Thesaurus Term: Hydrocarbons; Thesaurus Term: Escherichia coli; Thesaurus Term: Gram-positive bacteria; Subject Term: Mycobacterium; Subject Term: Genes; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 13p; Document Type: Article
L3 - 10.1099/mic.0.27263-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chirino, Arthur J.
AU - Mire-Sluis, Anthony
T1 - Characterizing biological products and assessing comparability following manufacturing changes.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2004/11//
VL - 22
IS - 11
M3 - Article
SP - 1383
EP - 1391
SN - 10870156
AB - Changes in production methods of a biological product may necessitate an assessment of comparability to ensure that these manufacturing changes have not affected the safety, identity, purity, or efficacy of the product. Depending on the nature of the protein or the change, this assessment consists of a hierarchy of sequential tests in analytical testing, preclinical animal studies and clinical studies. Differences in analytical test results between pre- and post-change products may require functional testing to establish the biological or clinical significance of the observed difference. An underlying principle of comparability is that under certain conditions, protein products may be considered comparable on the basis of analytical testing results alone. However, the ability to compare biological materials is solely dependent on the tests used, since no single analytical method is able to compare every aspect of protein structure or function. The advantages and disadvantages of any given method depends on the protein property being characterized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological products
KW - Natural products
KW - Biotechnology
KW - Manufacturing processes
KW - Proteins
KW - Production planning
N1 - Accession Number: 14945667; Chirino, Arthur J. 1; Email Address: art@xencor.com; Mire-Sluis, Anthony 2; Affiliations: 1: Xencor Inc., 111 West Lemon Avenue, Monrovia, Calfornia 91016, USA.; 2: Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, 1451 Rockville Pike, Maryland 20852, USA.; Issue Info: Nov2004, Vol. 22 Issue 11, p1383; Thesaurus Term: Biological products; Thesaurus Term: Natural products; Thesaurus Term: Biotechnology; Subject Term: Manufacturing processes; Subject Term: Proteins; Subject Term: Production planning; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; Number of Pages: 9p; Document Type: Article
L3 - 10.1038/nbt1030
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Eakle, Melissa
AU - Lenge, Susan
T1 - Power injectors put I.V. lines under pressure.
JO - Nursing
JF - Nursing
Y1 - 2004/11//
VL - 34
IS - 11
M3 - Article
SP - 29
EP - 29
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article presents information on power injectors put I.V. lines under pressure. During a computed tomography scan, a power injector was used to administer contrast media into a patient's I.V. access site. Contrast media suddenly sprayed out of the I.V. administration set connector and into her face and eyes. Power injectors are used to inject radiopaque contrast media at controlled rates during diagnostic studies to enhance the diagnostic image. Manufacturers of power injectors recommend using catheters, tubing, and connectors labeled for use with power injectors; these can withstand the higher pressures.
KW - INTRAVASCULAR ultrasonography
KW - TOMOGRAPHY
KW - CATHETERS
KW - RADIOGRAPHY -- Equipment & supplies
KW - NONINVASIVE diagnostic tests
KW - DIAGNOSTIC imaging
N1 - Accession Number: 14842865; Eakle, Melissa 1 Lenge, Susan 2; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health of the Food and Drug Administration in Rodwille, Md. 2: Medical imaging specialist, Center for Devices and Radiological Health of the Food and Drug Administration in Rodwille, Md.; Source Info: Nov2004, Vol. 34 Issue 11, p29; Subject Term: INTRAVASCULAR ultrasonography; Subject Term: TOMOGRAPHY; Subject Term: CATHETERS; Subject Term: RADIOGRAPHY -- Equipment & supplies; Subject Term: NONINVASIVE diagnostic tests; Subject Term: DIAGNOSTIC imaging; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106555182
T1 - Device safety. Power injectors put I.V. lines under pressure.
AU - Eakle M
AU - Lange S
Y1 - 2004/11//
N1 - Accession Number: 106555182. Language: English. Entry Date: 20050107. Revision Date: 20150820. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Catheters, Vascular
KW - Contrast Media -- Administration and Dosage
KW - Equipment Failure
KW - Tomography, X-Ray Computed
KW - Pressure
SP - 29
EP - 29
JO - Nursing
JF - Nursing
JA - NURSING
VL - 34
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
U2 - PMID: 15686310.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Buist, Diana S. M.
AU - Newton, Katherine M.
AU - Miglioretti, Diana L.
AU - Beverly, Kevin
AU - Connelly, Maureen T.
AU - Andrade, Susan
AU - Hartsfield, Cynthia L.
AU - Feifei Wei
AU - Chan, K. Arnold
AU - Kessler, Larry
T1 - Hormone Therapy Prescribing Patterns in the United States.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2004/11//
VL - 104
IS - 5 part 1
M3 - Article
SP - 1042
EP - 1050
SN - 00297844
AB - OBJECTIVE: We sought to examine prescribing patterns (prevalence and rates of initiation and discontinuation) for estrogen plus progestin (hormone therapy [HT] and estrogen alone [ET]) in the United States in the 2 years before the published results of Women's Health Initiative's (WHI) HT trial's early termination and for 5 months after their release. METHODS: We conducted an observational cohort study of 169,586 women aged 40-80 years who were enrolled in 5 health maintenance organizations in the United States to estimate the prevalence of HT and ET and discontinuation and initiation rates between September 1, 1999, to June 31, 2002 (baseline), and December 31, 2002 (follow-up). We used automated pharmacy data to identify all oral and transdermal estrogen and progestin dispensed during the study period. RESULTS: The prevalence of HT declined 46% from baseline to follow-up (14.6% to 7.9%); ET use declined 28% during the same period (12.6% to 9.1%). The discontinuation of HT increased almost immediately, from 2.5% at baseline to 13.8% in October 2002. We saw an immediate decrease in LIT and ET initiation rates, from 0.4% and 0.3% at baseline, respectively, to 0.2% for HT and ET at follow-up. CONCLUSION: The diffusion of the Will HT trial results had an immediate impact on the discontinuation of HT and ET and is likely responsible for the 46% and 28% decline in the initiation of these respective therapies. Further exploration of why women continue to use HT and identification of methods for addressing reasons for continued use are indicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Obstetrics & Gynecology is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HORMONE therapy
KW - ESTROGEN
KW - PROGESTATIONAL hormones
KW - HEALTH maintenance organizations
KW - PHARMACY
KW - UNITED States
N1 - Accession Number: 18047529; Buist, Diana S. M. 1; Email Address: buist.d@ghc.org Newton, Katherine M. 1 Miglioretti, Diana L. 1 Beverly, Kevin 1 Connelly, Maureen T. 1 Andrade, Susan 1 Hartsfield, Cynthia L. 1 Feifei Wei 1 Chan, K. Arnold 1 Kessler, Larry 1; Affiliation: 1: From the Center for Health Studies, Group Health Cooperative, Seattle, Washington; University of Washington, School of Public Health and Community Medicine, Seattle, Washington; Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care; Harvard Medical School and Menopause Consultation Service and Harvard Vanguard Medical Associates, Boston, Massachusetts; Meyers Primary Care Institute, Worcester, Massachusetts; Kaiser Permanente, Denver, Colorado; Health Partners Research Foundation, Minneapolis, Minnesota; Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Health Maintenance Organization Research Network Center for Education and Research on Therapeutics; and Office of Science and Technology, Center for Devices and Radiological Health, US. Food and Drug Administration, Rockville, Maryland; Source Info: Nov2004, Vol. 104 Issue 5 part 1, p1042; Subject Term: HORMONE therapy; Subject Term: ESTROGEN; Subject Term: PROGESTATIONAL hormones; Subject Term: HEALTH maintenance organizations; Subject Term: PHARMACY; Subject Term: UNITED States; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 9p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1097/01.AOG.0000143826.38439.af
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fillmore, Gary L.
AU - Ward, Thomas P.
AU - Bower, Kraig S.
AU - Dudenhoefer, Eric J.
AU - Grabenstein, John D.
AU - Berry, G. Keith
AU - Madigan Jr, William P.
T1 - Ocular complications in the Department of Defense Smallpox Vaccination Program
JO - Ophthalmology
JF - Ophthalmology
Y1 - 2004/11//
VL - 111
IS - 11
M3 - Article
SP - 2086
EP - 2093
SN - 01616420
AB - Objective: The purpose of this case series was to present an overview of the nature and frequency of ocular complications in the Department of Defense (DoD) Smallpox Vaccination Program.Design: Retrospective, noncomparative case series.Participants: The authors retrospectively evaluated data collected on individuals with an ophthalmologic complaint after receiving smallpox vaccination or after contact with a recently immunized individual. The vaccinee and contact cases occurred secondary to inoculations given between December 13, 2002 and May 28, 2003 as part of the DoD Smallpox Vaccination Program.Methods: Data were collected primarily from reports to military headquarters or to the Vaccine Adverse Event Reporting System and individual medical records.Main outcome measures: The incidence, types, and timing of ocular complications were evaluated. Diagnostic and treatment considerations also were reviewed.Results: Between December 13, 2002 and May 28, 2003, 450,293 smallpox vaccinations were given. We identified 16 confirmed or probable cases of ocular vaccinia, with an incidence of 3.6 per 100,000 inoculations. Of these cases, 12 (75%) were seen in the vaccinees, and 4 (25%) in close contacts. Of the 12 self-inoculation cases, 7 (58.3%) were seen in individuals receiving the vaccine for the first time (primary vaccination), and 3 (25.0%) were seen in individuals previously vaccinated (revaccination); the vaccination status in 2 cases was unknown. Clinical manifestations included lid pustules, blepharitis, periorbital cellulitis, conjunctivitis, conjunctival ulcers, conjunctival membranes, limbal pustules, corneal infiltrates, and iritis, with onset of symptoms 3 to 24 days after inoculation or contact. Five of 9 tested cases were culture or polymerase chain reaction positive for vaccinia. Treatment for most cases was topical trifluridine 1% (Viroptic; King Pharmaceuticals, Inc., Bristol, TN). Vaccinia immune globulin was used in 1 case. In all patients, recovery occurred without significant visual sequelae.Conclusions: When compared with historical data on the ocular complications of smallpox vaccination, the incidence of ocular complications during the DoD Smallpox Vaccination program has been low. In addition, the severity of disease seems to be less than during other vaccination periods. These findings perhaps are the result of improved screening of vaccinees, prevaccination counseling, postvaccination wound care, and the suggested efficacy of trifluridine in the treatment of ocular vaccinia. [Copyright &y& Elsevier]
AB - Copyright of Ophthalmology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMALLPOX -- Vaccination
KW - COMMUNICABLE diseases -- Prevention
KW - IMMUNIZATION
KW - HEALTH promotion
N1 - Accession Number: 14869727; Fillmore, Gary L. 1 Ward, Thomas P. 1 Bower, Kraig S. 1 Dudenhoefer, Eric J. 2 Grabenstein, John D. 3 Berry, G. Keith 2 Madigan Jr, William P. 1; Affiliation: 1: Ophthalmology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA 2: Department of Ophthalmology, Wilford Hall Air Force Medical Center, San Antonio, Texas, USA 3: Office of the Surgeon General, Headquarters, Department of the Army, Washington, DC, USA; Source Info: Nov2004, Vol. 111 Issue 11, p2086; Subject Term: SMALLPOX -- Vaccination; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: IMMUNIZATION; Subject Term: HEALTH promotion; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ophtha.2004.04.027
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106584575
T1 - The handling of patient cues and expressed emotions in psychiatric interviews after a communication skills training.
AU - Rimondini M
AU - Del Piccolo L
AU - Goss C
AU - Mazzi MA
AU - Paccaloni M
AU - Zimmermann C
Y1 - 2004/11//
N1 - Accession Number: 106584575. Language: English. Entry Date: 20050225. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Europe; Health Promotion/Education; Nursing; Peer Reviewed; UK & Ireland. Instrumentation: Verona Psychiatric Interview Classification System (VR-PICS). NLM UID: 8406280.
KW - Communication Skills Training
KW - Physician-Patient Relations
KW - Psychiatrists
KW - Chi Square Test
KW - Cues
KW - Emotions
KW - Italy
KW - Pretest-Posttest Design
KW - Research Instruments
KW - Videorecording
KW - Human
SP - 311
EP - 312
JO - Patient Education & Counseling
JF - Patient Education & Counseling
JA - PATIENT EDUC COUNS
VL - 55
IS - 2
PB - Elsevier Science
SN - 0738-3991
AD - Dept of Medicine and Public Health, Service of Medical Psychology, University of Verona, Italy
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zineh, I.
AU - Gerhard, T.
AU - Aquilante, C. L.
AU - Beitelshees, A. L.
AU - Beasley, BN
AU - Hartzema, A. G.
T1 - Availability of pharmacogenomics-based prescribing information in drug package inserts for currently approved drugs.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2004/11//
VL - 4
IS - 6
M3 - Article
SP - 354
EP - 358
PB - Nature Publishing Group
SN - 1470269X
AB - Examines the availability of pharmacogenomics (Pgx)-based prescribing information in drug package inserts for currently approved drugs. Aim of Pgx; Classes of drugs with Pgx data found in drug package inserts; Prescribing informations that are found in drug package inserts.
KW - PHARMACOGENOMICS
KW - LABELS
KW - PACKAGING
KW - DRUGS
N1 - Accession Number: 15090756; Zineh, I. 1,2; Email Address: zineh@cop.ufl.edu Gerhard, T. 3 Aquilante, C. L. 4 Beitelshees, A. L. 1,2 Beasley, BN 5 Hartzema, A. G. 3; Affiliation: 1: Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL, USA 2: University of Florida Center for Pharmacogenomics, Gainesville, FL, USA 3: Department of Pharmacy Health Care Administration, University of Florida College of Pharmacy, Gainesville, FL, USA 4: Department of Clinical Pharmacy, University of Colorado School of Pharmacy, Denver, CO, USA 5: US Food and Drug Administration, Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Rockville, MD, USA; Source Info: 2004, Vol. 4 Issue 6, p354; Subject Term: PHARMACOGENOMICS; Subject Term: LABELS; Subject Term: PACKAGING; Subject Term: DRUGS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1038/sj.tpj.6500284
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wysowski, Diane K.
AU - Nourjah, Parivash
T1 - ANALYZING PRESCRIPTION DRUGS AS CAUSES OF DEATH ON DEATH CERTIFICATES.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2004/11//Nov/Dec2004
VL - 119
IS - 6
M3 - Letter
SP - 520
EP - 520
SN - 00333549
AB - Discusses a study which analyzed the death certificates for deaths attributed to drugs used therapeutically done by the U.S. Office of Drug Safety of the Food and Drug Administration in collaboration with the Consumer Product Safety Commission. Findings of the study; Percentage of deaths associated with allergic reactions to drugs; Number of deaths caused by the use of steroids or corticosteroids; Limitations of the research.
KW - DEATH certificates
KW - DEATH -- Causes
KW - DRUGS
KW - DRUG allergy
KW - STEROIDS
KW - UNITED States. Food & Drug Administration
KW - U.S. Consumer Product Safety Commission
N1 - Accession Number: 14938916; Wysowski, Diane K. 1 Nourjah, Parivash 1; Affiliation: 1: Office of Drug Safety, Food and Drug Administration; Source Info: Nov/Dec2004, Vol. 119 Issue 6, p520; Subject Term: DEATH certificates; Subject Term: DEATH -- Causes; Subject Term: DRUGS; Subject Term: DRUG allergy; Subject Term: STEROIDS; Company/Entity: UNITED States. Food & Drug Administration Company/Entity: U.S. Consumer Product Safety Commission; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moon, Hojin
AU - Chen, James J.
AU - Gaylor, David W.
AU - Kodell, Ralph L.
T1 - A comparison of microbial dose–response models fitted to human data
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2004/11//
VL - 40
IS - 2
M3 - Article
SP - 177
EP - 184
SN - 02732300
AB - A study of eight mathematical dose–response models for microbial risk assessment was conducted using infectivity and illness data on a variety of microbial pathogens from published studies with human volunteers. The purpose was to evaluate variability among the models for human microbial dose–response data in order to determine whether two-parameter models might suffice for most microbial dose–response data or whether three-parameter models should generally be fitted. Model variability was measured in terms of estimated ED01s and ED10s, with the view that these effective dose levels correspond to the lower and upper limits of the 1–10% risk range generally recommended for establishing benchmark doses in risk assessment. An investigation of the ranks of the ED01 and ED10 values among the models led to the conclusion that the two-parameter models captured at least as much uncertainty as the three-parameter models for the data examined. A further evaluation of the two-parameter models did not result in the selection of one “best” model, but it did provide some insights into the models’ relative behavior. The model uncertainty analysis proposed by Kang et al. [Regulat. Toxicol. Pharmacol. 32 (2000) 68] using four two-parameter models was reinforced. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Infection
KW - Human behavior
KW - Uncertainty
KW - Benchmark dose
KW - Model uncertainty
N1 - Accession Number: 14514477; Moon, Hojin 1; Chen, James J. 1; Gaylor, David W. 2; Kodell, Ralph L.; Email Address: rkodell@nctr.fda.gov; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Gaylor and Associates, LLC, 453 County Road 212, Eureka Springs, AR 72631, USA; Issue Info: Nov2004, Vol. 40 Issue 2, p177; Thesaurus Term: Risk assessment; Thesaurus Term: Infection; Thesaurus Term: Human behavior; Subject Term: Uncertainty; Author-Supplied Keyword: Benchmark dose; Author-Supplied Keyword: Model uncertainty; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.yrtph.2004.07.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murono, Eisuke P.
AU - Derk, Raymond C.
T1 - The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2004/11//
VL - 19
IS - 1
M3 - Article
SP - 135
EP - 146
SN - 08906238
AB - Methoxychlor (MC) is an insecticide that is currently used on a variety of agricultural crops, especially following the ban of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) use in the United States. Following in vivo administration, MC is converted to 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which is proposed to be the active agent. Both MC and HPTE have been demonstrated to exhibit weak estrogenic and antiandrogenic activities, and they are thought to exert their effects through estrogen or androgen receptors, respectively. A recent study reported that HPTE inhibited both basal and hCG-stimulated testosterone formation by immature and adult cultured rat Leydig cells and that this effect was mediated through the estrogen receptor. In the current studies, we examined the effects of HPTE on basal and hCG-stimulated testosterone formation by cultured Leydig cells from young adult rats. In addition, we evaluated whether the effects of HPTE on rat Leydig cell testosterone biosynthesis were mediated through the estrogen receptor as an estrogen agonist or the androgen receptor as an antiandrogen. The current studies demonstrated that HPTE inhibited both basal and hCG-stimulated testosterone formation in a dose-dependent manner with significant declines in testosterone being observed at ∼100nM. The effects of HPTE were localized to the cholesterol side-chain cleavage step; however, these effects were not mediated through the classic estrogen receptor or by its acting as an antiandrogen, the currently recognized modes of action of MC and HPTE. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TESTOSTERONE
KW - LEYDIG cells
KW - ESTROGEN
KW - METHOXYCHLOR
KW - HPTE
KW - Leydig cell
KW - Testosterone
N1 - Accession Number: 14250576; Murono, Eisuke P.; Email Address: eem8@cdc.gov Derk, Raymond C. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road Morgantown, WV 26505, USA; Source Info: Nov2004, Vol. 19 Issue 1, p135; Subject Term: TESTOSTERONE; Subject Term: LEYDIG cells; Subject Term: ESTROGEN; Subject Term: METHOXYCHLOR; Author-Supplied Keyword: HPTE; Author-Supplied Keyword: Leydig cell; Author-Supplied Keyword: Testosterone; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.reprotox.2004.06.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jordan Lin, Chung-Tung
AU - Lee, Jonq-Ying
AU - Yen, Steven T.
T1 - Do dietary intakes affect search for nutrient information on food labels?
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2004/11//
VL - 59
IS - 9
M3 - Article
SP - 1955
EP - 1967
SN - 02779536
AB - Nutrition labels on food packages are designed to promote and protect public health by providing nutrition information so that consumers can make informed dietary choices. High levels of total fat, saturated fat and cholesterol in diets are linked to increased blood cholesterol levels and a greater risk of heart disease. Therefore, an understanding of consumer use of total fat, saturated fat, and cholesterol information on food labels has important implications for public health and nutrition education. This study explores the association between dietary intakes of these three nutrients and psychological or demographic factors and the search for total fat, saturated fat, and cholesterol information on food labels. Psychology literature suggests a negative association between intakes of these nutrients and probability of search for their information on food labels. Health behavior theories also suggest perceived benefits and costs of using labels and perceived capability of using labels are associated with the search behavior. We estimate the relationship between label information search and its predictors using logistic regressions. Our samples came from the 1994–1996 Continuing Survey of Food Intakes by Individuals and Diet and Health Knowledge Survey conducted by the United States Department of Agriculture. Results suggest that search for total fat, saturated fat, and cholesterol information on food labels is less likely among individuals who consume more of the three nutrients, respectively. The search is also related to perceived benefits and costs of using the label, perceived capability of using the label, knowledge of nutrition and fats, perceived efficacy of diets in reducing the risk of illnesses, perceived importance of nutrition in food shopping, perceived importance of a healthy diet, and awareness of linkage between excessive consumption of the nutrients and health problems. These findings suggest encouraging search of food label information among consumers with unhealthy dietary habits would need innovative approaches. Yet, nutrition education can be instrumental in encouraging this search by stimulating motivation and providing technical help. [Copyright &y& Elsevier]
AB - Copyright of Social Science & Medicine is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION
KW - INFORMATION resources
KW - FOOD -- Packaging
KW - HEALTH behavior
KW - UNITED States
KW - Binary choice model
KW - Fat
KW - Food labels
KW - Information search
KW - Nutrition
KW - USA
N1 - Accession Number: 14101883; Jordan Lin, Chung-Tung 1 Lee, Jonq-Ying 2 Yen, Steven T. 3; Email Address: syen@utk.edu; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-727, College Park, MD 20740-3835, USA 2: Florida Department of Citrus, PO Box 110249, University of Florida, Gainesville, FL 32601-0249, USA 3: Department of Agricultural Economics, 308D Morgan Hall, University of Tennessee, Knoxville, TN 37996-4518, USA; Source Info: Nov2004, Vol. 59 Issue 9, p1955; Subject Term: NUTRITION; Subject Term: INFORMATION resources; Subject Term: FOOD -- Packaging; Subject Term: HEALTH behavior; Subject Term: UNITED States; Author-Supplied Keyword: Binary choice model; Author-Supplied Keyword: Fat; Author-Supplied Keyword: Food labels; Author-Supplied Keyword: Information search; Author-Supplied Keyword: Nutrition; Author-Supplied Keyword: USA; NAICS/Industry Codes: 327213 Glass Container Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.socscimed.2004.02.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106595302
T1 - Do dietary intakes affect search for nutrient information on food labels?
AU - Lin CJ
AU - Lee J
AU - Yen ST
Y1 - 2004/11//
N1 - Accession Number: 106595302. Language: English. Entry Date: 20050318. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8303205.
KW - Diet
KW - Food Labeling
KW - Cholesterol, Dietary
KW - Cognitive Dissonance
KW - Descriptive Statistics
KW - Dietary Fats
KW - Nutrition Education
KW - P-Value
KW - T-Tests
KW - Human
SP - 1955
EP - 1967
JO - Social Science & Medicine
JF - Social Science & Medicine
JA - SOC SCI MED
VL - 59
IS - 9
PB - Pergamon Press - An Imprint of Elsevier Science
AB - Nutrition labels on food packages are designed to promote and protect public health by providing nutrition information so that consumers can make informed dietary choices. High levels of total fat, saturated fat and cholesterol in diets are linked to increased blood cholesterol levels and a greater risk of heart disease. Therefore, an understanding of consumer use of total fat, saturated fat, and cholesterol information on food labels has important implications for public health and nutrition education. This study explores the association between dietary intakes of these three nutrients and psychological or demographic factors and the search for total fat, saturated fat, and cholesterol information on food labels. Psychology literature suggests a negative association between intakes of these nutrients and probability of search for their information on food labels. Health behavior theories also suggest perceived benefits and costs of using labels and perceived capability of using labels are associated with the search behavior. We estimate the relationship between label information search and its predictors using logistic regressions. Our samples came from the 1994-1996 Continuing Survey of Food Intakes by Individuals and Diet and Health Knowledge Survey conducted by the United States Department of Agriculture. Results suggest that search for total fat, saturated fat, and cholesterol information on food labels is less likely among individuals who consume more of the three nutrients, respectively. The search is also related to perceived benefits and costs of using the label, perceived capability of using the label, knowledge of nutrition and fats, perceived efficacy of diets in reducing the risk of illnesses, perceived importance of nutrition in food shopping, perceived importance of a healthy diet, and awareness of linkage between excessive consumption of the nutrients and health problems. These findings suggest encouraging search of food label information among consumers with unhealthy dietary habits would need innovative approaches. Yet, nutrition education can be instrumental in encouraging this search by stimulating motivation and providing technical help.
SN - 0277-9536
AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-727, College Park, MD 20740-3835
U2 - PMID: 15312929.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jianyong Wang
AU - Xiaoli Liu
AU - Heflich, Robert H.
AU - Tao Chen
T1 - Time Course of cII Gene Mutant Manifestation in the Liver, Spleen, and Bone Marrow of N-Ethyl-N-Nitrosourea-Treated Big Blue Transgenic Mice.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/11//
VL - 82
IS - 1
M3 - Article
SP - 124
EP - 128
PB - Oxford University Press / USA
SN - 10966080
AB - The time between treatment and the appearance of mutants (mutant manifestation time) is a critical variable for in vivo transgenic mutation assays. There are, however, limited data describing the optimal sampling time for detecting mutations in various tissues of mutagen-treated animals. In this study, we investigated the time course of cII gene mutant induction in the liver, spleen, and bone marrow of Big Blue transgenic mice treated with N-ethyl-N-nitrosourea (ENU). Six-month-old female mice were treated with a single dose (120 mg/kg) of ENU, and the animals were sacrificed, and the cII mutant frequencies (MFs) were determined at 1, 3, 7, 15, 30, and 120 days after the treatment. The MFs in the liver cII gene of ENU-treated mice increased with time after the treatment, while the MFs for concurrent controls remained constant. The liver cII MFs in ENU-treated mice were significantly increased at day 30 and 120 (p < 0.01), with the largest increase at day 120. The spleen cII MFs in ENU-treated mice were increased significantly at day 7 and later (p < 0.01), and reached a plateau at day 30. In the bone marrow, the cII MFs in ENU-treated mice were increased significantly at all sampling times (p < 0.01), with the maximum MF at day 3. These results confirm that the time after treatment required to reach the maximum MF is tissue specific, with the approximate time for the maximum ENU-induced cII MF response being: bone marrow, 3 days; spleen, 14–30 days; and liver, more than 30 days. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Transgenic animals
KW - Nitrosoureas
KW - Mutagenesis
KW - Liver cells
KW - Bone marrow
KW - Big Blue transgenic mice
KW - mutant manifestation
KW - mutation assay
KW - N-ethyl-N-nitrosourea
N1 - Accession Number: 20736997; Jianyong Wang 1,2; Xiaoli Liu 1; Heflich, Robert H. 1,2; Tao Chen 1; Email Address: tchen@nctr.fda.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079; 2: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; Issue Info: Nov2004, Vol. 82 Issue 1, p124; Thesaurus Term: Mutation (Biology); Thesaurus Term: Transgenic animals; Subject Term: Nitrosoureas; Subject Term: Mutagenesis; Subject Term: Liver cells; Subject Term: Bone marrow; Author-Supplied Keyword: Big Blue transgenic mice; Author-Supplied Keyword: mutant manifestation; Author-Supplied Keyword: mutation assay; Author-Supplied Keyword: N-ethyl-N-nitrosourea; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1093/toxsci/kfh234
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yin, Xuejun J.
AU - a, Jane Y. C.
AU - Antonini, James M.
AU - Castranova, Vincent
AU - Ma, Joseph K. H.
T1 - Roles of Reactive Oxygen Species and Heme Oxygenase-1 in Modulation of Alveolar Macrophage-Mediated Pulmonary Immune Responses to Listeria monocytogenes by Diesel Exhaust Particles.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/11//
VL - 82
IS - 1
M3 - Article
SP - 143
EP - 153
PB - Oxford University Press / USA
SN - 10966080
AB - Diesel exhaust particles (DEP) have been shown to suppress alveolar macrophage (AM)-mediated pulmonary immune responses to Listeria monocytogenesin vivo. In this study, effects of DEP-derived reactive oxygen species (ROS) and heme oxygenase (HO)-1 on AM-mediated immune responses to L. monocytogenes were investigated. Brown Norway rats were intratracheally inoculated with 100,000 L. monocytogenes, and AM were isolated at 7 days post-infection. Exposure to DEP or their organic extract (eDEP), but not the washed DEP (wDEP) or carbon black, increased intracellular ROS and HO-1 expression in AM. Induction of ROS and HO-1 by eDEP was partially reversed by ?-naphthoflavone, a cytochrome P450 1A1 inhibitor, and totally blocked by N-acetylcysteine. In addition, exposure to eDEP, but not wDEP, inhibited lipopolysacchride-stimulated secretion of tumor necrosis factor-? (TNF-?) and interleukin-12 (IL-12), but augmented production of IL-10 by AM. Kinetic studies showed that modulation of cytokines by eDEP was preceded by ROS and HO-1 induction. Furthermore, pretreatment of AM with superoxide dismutase (SOD) or zinc protoporphrin IX (Znpp), which attenuated eDEP-induced HO-1 expression/activity, substantially inhibited eDEP effect on IL-10. Finally, direct stimulation with pyrogallol (PYR), a superoxide donor, upregulated HO-1 and IL-10 but decreased secretion of IL-12 in L. monocytogenes-infected AM. These results show that DEP, through eDEP-mediated ROS, induce HO-1 expression and IL-10 production and at the same time inhibit AM production of TNF-? and IL-12 to dampen the host immune responses. The results also suggest that HO-1 may play an important role in regulating production of IL-10 by DEP-exposed and L. monocytogenes-infected AM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Alveolar nerve
KW - Active oxygen
KW - Listeria monocytogenes
KW - Heme oxygenase
KW - Gene expression
KW - Superoxide dismutase
KW - cytokines
KW - diesel exhaust particles
KW - heme oxygenase-1
KW - reactive oxygen species
N1 - Accession Number: 20737017; Yin, Xuejun J. 1; a, Jane Y. C. 2; Antonini, James M. 2; Castranova, Vincent 2; Ma, Joseph K. H. 1; Email Address: jma@hsc.wvu.edu; Affiliations: 1: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Nov2004, Vol. 82 Issue 1, p143; Subject Term: Alveolar nerve; Subject Term: Active oxygen; Subject Term: Listeria monocytogenes; Subject Term: Heme oxygenase; Subject Term: Gene expression; Subject Term: Superoxide dismutase; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: heme oxygenase-1; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 11p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfh255
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20737017&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Byun, Jung A.
AU - Park, Seung Hee
AU - Kim, Hyung Soo
AU - Park, Jae Hyun
AU - Eom, Juno H.
AU - Oh, Hye Young
T1 - Evaluation of the potential immunotoxicity of 3-monochloro-1,2-propanediol in Balb/c mice: I. Effect on antibody forming cell, mitogen-stimulated lymphocyte proliferation, splenic subset, and natural killer cell activity
JO - Toxicology
JF - Toxicology
Y1 - 2004/11//
VL - 204
IS - 1
M3 - Article
SP - 1
EP - 11
SN - 0300483X
AB - 3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. MCPD has been reported genotoxic in vitro, and reproductive toxicity and carcinogenicity in rats. However, no previous studies have investigated MCPD-induced alterations in the immune system. In the present study, MCPD was administered by gavage for 14 days at 0, 25, 50, and 100 mg/kg per day to female Balb/c mice. The antibody-mediated immune response to sheep red blood cells (SRBC) was assessed using the antibody-forming cell (AFC) assay, and splenic cell phenotypes were quantified by flow cytometry. Hematological and histopathological changes were assessed. Mitogen-stimulated spleen lymphocyte proliferation and natural killer (NK) cell activity were evaluated. The T-lymphocyte blastogenesis by concanavalin A (Con A) or anti-CD3 and B-lymphocyte blastogenesis by lipopolysaccharide (LPS) were not significantly changed. There were no significant changes in the hematological and histopathological findings of MCPD-treated mice. However, the significant decrease in thymus weight was observed in 100 mg dose group, even though that did not change body weight gain. The cellularities of spleen and thymus were significantly reduced in high-dose group. Exposure to high dose of MCPD decreased the AFC response to SRBC in mice. There was a significant decrease in NK cell activity of mice treated with high dose of MCPD. These results indicate that MCPD could modulate the immune function in Balb/c mice. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOGENS
KW - MALONIC acid
KW - CELL proliferation
KW - IMMUNOTOXICOLOGY
KW - SOY sauce manufacturing
KW - AFC
KW - Cellularity
KW - Immunotoxicity
KW - MCPD
KW - Mitogen
KW - NK activity
N1 - Accession Number: 14428426; Lee, Jong Kwon; Email Address: jkleest@yahoo.com Byun, Jung A. 1 Park, Seung Hee 1 Kim, Hyung Soo 1 Park, Jae Hyun 1 Eom, Juno H. 1 Oh, Hye Young 1; Affiliation: 1: Division of Immunotoxicology, National Institute of Toxicological Korea Food and Drug Administration, 122-704 Seoul, South Korea; Source Info: Nov2004, Vol. 204 Issue 1, p1; Subject Term: MITOGENS; Subject Term: MALONIC acid; Subject Term: CELL proliferation; Subject Term: IMMUNOTOXICOLOGY; Subject Term: SOY sauce manufacturing; Author-Supplied Keyword: AFC; Author-Supplied Keyword: Cellularity; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: MCPD; Author-Supplied Keyword: Mitogen; Author-Supplied Keyword: NK activity; NAICS/Industry Codes: 311941 Mayonnaise, Dressing, and Other Prepared Sauce Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.tox.2004.04.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14428426&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Taylor, Michael D.
AU - Millecchia, Lyndell
AU - Bebout, Alicia R.
AU - Roberts, Jenny R.
T1 - Suppression in lung defense responses after bacterial infection in rats pretreated with different welding fumes
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/11//
VL - 200
IS - 3
M3 - Article
SP - 206
EP - 218
SN - 0041008X
AB - Epidemiology suggests that inhalation of welding fumes increases the susceptibility to lung infection. The effects of chemically distinct welding fumes on lung defense responses after bacterial infection were compared. Fume was collected during gas metal arc (GMA) or flux-covered manual metal arc (MMA) welding using two consumable electrodes: stainless steel (SS) or mild steel (MS). The fumes were separated into water-soluble and -insoluble fractions. The GMA-SS and GMA-MS fumes were found to be relatively insoluble, whereas the MMA-SS was highly water soluble, with the soluble fraction comprised of 87% Cr and 11% Mn. On day 0, male Sprague–Dawley rats were intratracheally instilled with saline (vehicle control) or the different welding fumes (0.1 or 2 mg/rat). At day 3, the rats were intratracheally inoculated with 5 × 103 Listeria monocytogenes. On days 6, 8, and 10, left lungs were removed, homogenized, cultured overnight, and colony-forming units were counted to assess pulmonary bacterial clearance. Bronchoalveolar lavage (BAL) was performed on right lungs to recover phagocytes and BAL fluid to measure the production of nitric oxide (NO) and immunomodulatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-6, and IL-10. In contrast to the GMA-SS, GMA-MS, and saline groups, pretreatment with the highly water soluble MMA-SS fume caused significant body weight loss, extensive lung damage, and a dramatic reduction in pulmonary clearance of L. monocytogenes after infection. NO concentrations in BAL fluid and lung immunostaining of inducible NO synthase were dramatically increased in rats pretreated with MMA-SS before and after infection. MMA-SS treatment caused a significant decrease in IL-2 and significant increases in TNF-α, IL-6, and IL-10 after infection. In conclusion, pretreatment with MMA-SS increased production of NO and proinflammatory cytokines (TNF-α and IL-6) after infection, which are likely responsible for the elevation in lung inflammation and injury. In addition, MMA-SS treatment reduced IL-2 (involved in T cell proliferation) and enhanced IL-10 (involved in inhibiting macrophage function) after bacterial infection, which might result in a possible suppression in immune response and an increase in susceptibility to infection. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cellular immunity
KW - Nitric oxide
KW - Cytokines
KW - Listeria monocytogenes
KW - Bacterial clearance
KW - Macrophage
KW - Welding fume
KW - Cytokines
N1 - Accession Number: 14783897; Antonini, James M.; Email Address: jga6@cdc.gov; Taylor, Michael D. 1; Millecchia, Lyndell 1; Bebout, Alicia R. 1; Roberts, Jenny R. 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 USA; Issue Info: Nov2004, Vol. 200 Issue 3, p206; Thesaurus Term: Cellular immunity; Thesaurus Term: Nitric oxide; Subject Term: Cytokines; Subject Term: Listeria monocytogenes; Author-Supplied Keyword: Bacterial clearance; Author-Supplied Keyword: Macrophage; Author-Supplied Keyword: Welding fume; Author-Supplied Keyword: Cytokines; Language of Keywords: English; Language of Keywords: Abkhazian; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.taap.2004.04.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14783897&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Plakas, Steven M.
AU - Wang, Zhihong
AU - El Said, Kathleen R.
AU - Jester, Edward L.E.
AU - Granade, Hudson R.
AU - Flewelling, Leanne
AU - Scott, Paula
AU - Dickey, Robert W.
T1 - Brevetoxin metabolism and elimination in the Eastern oyster (Crassostrea virginica) after controlled exposures to Karenia brevis
JO - Toxicon
JF - Toxicon
Y1 - 2004/11//
VL - 44
IS - 6
M3 - Article
SP - 677
EP - 685
SN - 00410101
AB - The metabolism and elimination of brevetoxins were examined in the Eastern oyster (Crassostrea virginica) following controlled exposures to Karenia brevis cultures in the laboratory. After a 2-day exposure period (∼62 million cells/oyster), elimination of brevetoxins and their metabolites was monitored by using liquid chromatography/mass spectrometry (LC/MS). Composite toxin in oyster extracts was measured by in vitro assay (i.e. cytotoxicity, receptor binding, and ELISA). Of the parent algal toxins, PbTx-1 and PbTx-2 were not detectable by LC/MS in K. brevis-exposed oysters. PbTx-3 and PbTx-9, which are accumulated directly from K. brevis and through metabolic reduction of PbTx-2 in the oyster, were at levels initially (after exposure) of 0.74 and 0.49μgequiv./g, respectively, and were eliminated largely within 2 weeks after dosing. PbTx-7 and PbTx-10, the reduced forms of PbTx-1, were non-detectable. Conjugative brevetoxin metabolites identified previously in field-exposed oysters were confirmed in the laboratory-exposed oysters. Cysteine conjugates of PbTx-1 and PbTx-2, and their sulfoxides, were in the highest abundance, as apparent in LC/MS ion traces, and were detectable for up to 6 months after dosing. Composite toxin measurements by in vitro assay also reflected persistence (up to 6 months) of brevetoxin residues in the oyster. Levels of cysteine conjugates, as determined by LC/MS, were well correlated with those of composite toxin, as measured by ELISA, throughout depuration. Composite toxin levels by cytotoxicity assay were well correlated with those by receptor binding assay. Cysteine–PbTx conjugates are useful LC/MS determinants of brevetoxin exposure and potential markers for composite toxin in the Eastern oyster. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - AMERICAN oyster
KW - CHROMATOGRAPHIC analysis
KW - CRASSOSTREA
KW - Brevetoxin
KW - Eastern oyster
KW - Elimination
KW - Liquid chromatography/mass spectrometry.
KW - Metabolism
N1 - Accession Number: 14784171; Plakas, Steven M.; Email Address: splakas@cfsan.fda.gov Wang, Zhihong 1 El Said, Kathleen R. 1 Jester, Edward L.E. 1 Granade, Hudson R. 1 Flewelling, Leanne 2 Scott, Paula 2 Dickey, Robert W. 1; Affiliation: 1: Gulf Coast Seafood Laboratory, US Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA 2: Florida Fish and Wildlife Conservation Commission, Florida Marine Research Institute, 100 8th Avenue SE, St Petersburg, FL 33701-5020, USA; Source Info: Nov2004, Vol. 44 Issue 6, p677; Subject Term: METABOLISM; Subject Term: AMERICAN oyster; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CRASSOSTREA; Author-Supplied Keyword: Brevetoxin; Author-Supplied Keyword: Eastern oyster; Author-Supplied Keyword: Elimination; Author-Supplied Keyword: Liquid chromatography/mass spectrometry.; Author-Supplied Keyword: Metabolism; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.toxicon.2004.07.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14784171&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2004-22481-001
AN - 2004-22481-001
AU - Kruesi, Markus J.P.
AU - Casanova, Manuel F.
AU - Mannheim, Glenn
AU - Johnson-Bilder, Adrienne
T1 - Reduced temporal lobe volume in early onset conduct disorder.
JF - Psychiatry Research: Neuroimaging
JO - Psychiatry Research: Neuroimaging
Y1 - 2004/11//
VL - 132
IS - 1
SP - 1
EP - 11
CY - Netherlands
PB - Elsevier Science
SN - 0925-4927
AD - Kruesi, Markus J.P., Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, P.O. Box 250861, Charleston, SC, US, 29425
N1 - Accession Number: 2004-22481-001. PMID: 15546698 Partial author list: First Author & Affiliation: Kruesi, Markus J.P.; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, US. Release Date: 20050118. Correction Date: 20130401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain Size; Conduct Disorder; Magnetic Resonance Imaging; Onset (Disorders); Temporal Lobe. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Wechsler Adult Intelligence Scale (WAIS); Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Longitudinal Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov, 2004.
AB - Regional brain volumes derived from magnetic resonance imaging (MRI) scans from 10 youths with early onset conduct disorder and 10 healthy controls matched for age, sex and handedness were compared to determine whether prefrontal or temporal lobe brain volumes differed in the two groups. Right temporal lobe and right temporal gray matter volumes were significantly reduced in subjects with conduct disorder compared with controls. Prefrontal volumes in subjects with conduct disorder were 16% smaller than in controls, but the difference did not reach statistical significance. Early onset conduct disorder without substance abuse comorbidity was also significantly associated with smaller right temporal gray volumes. Further investigation of both the temporal and frontal localizations of the pathophysiology of early onset conduct disorder is warranted in larger samples. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - temporal lobe volume
KW - early onset
KW - conduct disorder
KW - magnetic resonance imaging
KW - brain
KW - 2004
KW - Brain Size
KW - Conduct Disorder
KW - Magnetic Resonance Imaging
KW - Onset (Disorders)
KW - Temporal Lobe
KW - 2004
DO - 10.1016/j.pscychresns.2004.07.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-22481-001&site=ehost-live&scope=site
UR - kruesi@musc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21206-001
AN - 2004-21206-001
AU - Wagner, Robert F.
AU - Beam, Craig A.
AU - Beiden, Sergey V.
T1 - Reader Variability in Mammography and Its Implications for Expected Utility over the Population of Readers and Cases.
JF - Medical Decision Making
JO - Medical Decision Making
JA - Med Decis Making
Y1 - 2004/11//Nov-Dec, 2004
VL - 24
IS - 6
SP - 561
EP - 572
CY - US
PB - Sage Publications
SN - 0272-989X
SN - 1552-681X
AD - Wagner, Robert F., Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, US, 20850
N1 - Accession Number: 2004-21206-001. PMID: 15534338 Partial author list: First Author & Affiliation: Wagner, Robert F.; Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, US. Release Date: 20050725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Mammography; Statistical Analysis. Minor Descriptor: Ability Level; Health Screening; Technology. Classification: Health Psychology & Medicine (3360). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Nov-Dec, 2004.
AB - The multiple-reader, multiple-case (MRMC) approach to receiver operating characteristic (ROC) analysis is becoming the dominant assessment paradigm in medical imaging. Its most common version involves having many readers read every patient case in the study, a critical feature since differences among competing imaging modalities are often dominated by differences in reader performance. The present authors have carried out MRMC ROC analysis on a uniquely large data set for mammography. The analysis quantifies the great range of observed reader skill in that data set. It also demonstrates that the sample sizes are sufficiently large that the conclusions generalize to the populations sampled here with little uncertainty from the finite sample size. A schematic approach to bracketing the utility matrix is then used to study trends in the resulting expected utility functions that correspond to the range of observed ROC curves. This is done for both the screening and the diagnostic context. The results raise 2 hypotheses for further investigation. First, it is possible that the present ambiguity surrounding the effectiveness of mammography is due in part to the observed range of reader skills and corresponding expected utility functions. Second, it is possible that computer-assisted modalities for mammography may lead to improvements in the expected utility function not only for screening but also in the diagnostic context, especially for the lower performing readers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mammography
KW - reader variations
KW - receiver operating characteristic analysis
KW - multiple reader multiple case approach
KW - 2004
KW - Decision Making
KW - Mammography
KW - Statistical Analysis
KW - Ability Level
KW - Health Screening
KW - Technology
KW - 2004
DO - 10.1177/0272989X04271043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21206-001&site=ehost-live&scope=site
UR - rfw@cdrh.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-01435-005
AN - 2005-01435-005
AU - Svensson, Eva B.
AU - Morata, Thais C.
AU - Nylén, Per
AU - Krieg, Edward F.
AU - Johnson, Ann-Christin
T1 - Beliefs and attitudes among Swedish workers regarding the risk of hearing loss.
JF - International Journal of Audiology
JO - International Journal of Audiology
JA - Int J Audiol
Y1 - 2004/11//Nov-Dec, 2004
VL - 43
IS - 10
SP - 585
EP - 593
CY - United Kingdom
PB - Taylor & Francis
SN - 1499-2027
SN - 1708-8186
AD - Svensson, Eva B., Unit of Technical Audiology, Department of Clinical Neuroscience, Karolinska Institutet, Bla vagen, hus 15, S-182 30, Danderyd, Sweden
N1 - Accession Number: 2005-01435-005. PMID: 15724523 Partial author list: First Author & Affiliation: Svensson, Eva B.; National Institute for Working Life, Program of Technical Hygiene, Umeå, Sweden. Other Publishers: Informa Healthcare. Release Date: 20050228. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Attitudes; Hearing Disorders; Occupational Exposure; Safety Devices. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: Sweden. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov-Dec, 2004.
AB - The beliefs and attitudes regarding the risk of hearing loss and their impact on hearing protector use were investigated among Swedish workers. A questionnaire, developed by the US National Institute for Occupational Safety and Health (NIOSH), was used. The study objective was to assess workers1 attitudes towards using hearing protection devices (HPDs) and to enhance the ability of workers to protect themselves from occupational hearing loss. Ninety-five per cent of the respondents were aware that loud noise could damage their hearing, 90% considered that a hearing loss would be a serious problem, and 85% believed that HPDs could protect their hearing. However, lower percentages of workers always used the HPDs when they were noise-exposed. Fifty-five per cent of the workers indicated that they could not hear warning signals when using HPDs, and 45% of the workers indicated that they considered HPDs to be uncomfortable. These issues must be addressed to make HPD use more effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hearing loss
KW - worker attitudes
KW - hearing protection device use
KW - 2004
KW - Employee Attitudes
KW - Hearing Disorders
KW - Occupational Exposure
KW - Safety Devices
KW - 2004
DO - 10.1080/14992020400050075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01435-005&site=ehost-live&scope=site
UR - eva.b.svensson@cns.ki.se
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21590-001
AN - 2004-21590-001
AU - O'Brien, Charles P.
AU - Charney, Dennis S.
AU - Lewis, Lydia
AU - Cornish, James W.
AU - Post, Robert M.
AU - Woody, George E.
AU - Zubieta, Jon-Kar
AU - Anthony, James C.
AU - Blaine, Jack D.
AU - Bowden, Charles L.
AU - Calabrese, Joseph R.
AU - Carroll, Kathleen
AU - Kosten, Thomas
AU - Rounsaville, Bruce
AU - Childress, Anna Rose
AU - Oslin, David W.
AU - Pettinati, Helen M.
AU - Davis, Mark A.
AU - DeMartino, Robert
AU - Drake, Robert E.
AU - Fleming, Michael F.
AU - Fricks, Larry
AU - Glassman, Alexander H.
AU - Levin, Frances R.
AU - Nunes, Edward V.
AU - Johnson, Robert L.
AU - Jordan, Clarence
AU - Kessler, Ronald C.
AU - Laden, Sally K.
AU - Regier, Darrel A.
AU - Renner, John A. Jr.
AU - Ries, Richard K.
AU - Sklar-Blake, Thomas
AU - Weisner, Constance
T1 - Priority Actions to Improve the Care of Persons with Co-occurring Substance Abuse and Other Mental Disorders: A Call to Action.
JF - Biological Psychiatry
JO - Biological Psychiatry
JA - Biol Psychiatry
Y1 - 2004/11//
VL - 56
IS - 10
SP - 703
EP - 713
CY - Netherlands
PB - Elsevier Science
SN - 0006-3223
AD - O'Brien, Charles P., Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA, US, 19104-6178
N1 - Accession Number: 2004-21590-001. PMID: 15556110 Partial author list: First Author & Affiliation: O'Brien, Charles P.; Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, US. Release Date: 20050207. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Comorbidity; Drug Abuse; Health Service Needs; Major Depression. Minor Descriptor: Professional Organizations; Substance Use Disorder. Classification: Affective Disorders (3211). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Nov, 2004.
AB - The Depression and Bipolar Support Alliance (DBSA) is the nation's largest, illness-specific organization run by and for people living with depression or bipolar disorder. In November 2003, the DBSA convened a conference to address the unmet needs of substance use disorders in persons with depression or bipolar disorder. The prevalence and severity of substance use disorders that are comorbid with other mental illnesses was acknowledged; however, the DBSA conference focused on comorbid mood and substance use disorders. Unless otherwise specified, the term 'substance use disorders' is used in this statement to include the full spectrum of abuse and dependence on alcohol, nicotine, and illegal and prescription drugs. Participants included 43 experts in psychiatry, psychology, addiction treatment, health care policy, primary care, adolescent health, epidemiology, and advocacy. Presentations and deliberations from the conference and articles published in this special issue of Biological Psychiatry (Vol 56) are reflected herein. Participants listened to presentations, debated workgroup reports, and provided input to interim versions of this statement. All authors approved the final version. The objectives of this statement are to assess available data, describe unmet needs, and outline priority clinical actions and research directions that are needed to improve treatment, access to care, and professional training. Recommendations for priority actions are evidence-based, when possible; however, there is a remarkable lack of empirical data in this area. When data are available, they are often gleaned from heterogeneous populations that include patients with psychiatric diagnoses other than mood disorders. Thus, by necessity, the remaining priority action recommendations are based on the opinions and clinical experiences of the experts who participated in this conference. This statement reflects input from all participants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Depression and Bipolar Support Alliance
KW - comorbidity
KW - depression
KW - bipolar disorder
KW - substance use disorders
KW - health care needs
KW - 2004
KW - Bipolar Disorder
KW - Comorbidity
KW - Drug Abuse
KW - Health Service Needs
KW - Major Depression
KW - Professional Organizations
KW - Substance Use Disorder
KW - 2004
DO - 10.1016/j.biopsych.2004.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21590-001&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3263-3374
UR -
UR - obrien@mail.trc.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21590-004
AN - 2004-21590-004
AU - Power, Kathryn
AU - DeMartino, Robert
T1 - Co-occurring Disorders and Achieving Recovery: The Substance Abuse and Mental Health Services Administration Perspective.
JF - Biological Psychiatry
JO - Biological Psychiatry
JA - Biol Psychiatry
Y1 - 2004/11//
VL - 56
IS - 10
SP - 721
EP - 722
CY - Netherlands
PB - Elsevier Science
SN - 0006-3223
AD - Power, Kathryn, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, 5600 Fishers Lane, Room 15-105, Rockville, MD, US, 20857
N1 - Accession Number: 2004-21590-004. PMID: 15556113 Partial author list: First Author & Affiliation: Power, Kathryn; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20050207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Health Care Delivery; Mental Health Services; Recovery (Disorders). Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Nov, 2004.
AB - The Substance Abuse and Mental Health Services Administration (SAMHSA) is the federal agency charged with improving the quality and availability of prevention, treatment, and rehabilitative services to reduce illness, death, disability, and cost to society resulting from substance abuse and mental illnesses. The SAMHSA perspective is people-centered and results-driven. The goal is simple: to improve outcomes for individuals of all ages who are at risk for or who have co-occurring disorders. Being able to reach the goal is a far more complex matter. In part, it depends on our ability to be guided by clearly defined principles and to overcome the numerous barriers to effective and coordinated care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - comorbidity
KW - substance abuse
KW - mental illness
KW - recovery
KW - health care delivery
KW - 2004
KW - Comorbidity
KW - Drug Abuse
KW - Health Care Delivery
KW - Mental Health Services
KW - Recovery (Disorders)
KW - 2004
DO - 10.1016/j.biopsych.2004.03.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21590-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-19767-012
AN - 2004-19767-012
AU - Paule, Merle G.
AU - Chelonis, John J.
AU - Blake, Donna J.
AU - Dornhoffer, John L.
T1 - Effects of drug countermeasures for space motion sickness on working memory in humans.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2004/11//Nov-Dec, 2004
VL - 26
IS - 6
SP - 825
EP - 837
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Paule, Merle G., Behavioral Toxicology Laboratories, Division of Neurotoxicology, USFDA's National Center for Toxicological Research, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2004-19767-012. PMID: 15451046 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Paule, Merle G.; Behavioral Toxicology Laboratories, Division of Neurotoxicology, USFDA's National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20050411. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Gravitational Effects; Motion Sickness; Short Term Memory; Spaceflight. Minor Descriptor: Drug Therapy; Teratogens; Weightlessness. Classification: Psychological & Physical Disorders (3200); Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Nov-Dec, 2004.
AB - Space motion sickness (SMS) is a problem during the first 72 h of space flight and during transitions from different gravity environments. There currently are no effective drug countermeasures for SMS that also accommodate the retention of optimal cognitive function. This creates a dilemma for astronauts because cognitive skills are particularly important during gravity transitions (e.g., take-off and landing). To quantify the cognitive side effects of potential drug countermeasures, an automated delayed matching-to-sample (DMTS) procedure was used to assess visual working memory before and after drug countermeasures (meclizine 25 mg, scopolamine 0.4 mg, promethazine 25 mg, or lorazepam 1 mg, given orally approximately 45 min prior to testing) and/or the induction of SMS by vestibular stimulation in a rotary chair (spinning). Sixty-seven normal healthy volunteers (mean age, in years, 26.6±4.8 S.D.; 24 females and 43 males) each participated in two test sessions, one 'off drug and one 'on' drug. Spinning by itself significantly decreased task accuracy (Acc) and choice response speed, especially at longer recall delays. Meclizine alone had no effect on Acc or speed with or without spinning. Scopolamine alone decreased Acc, and with spinning, slowed speed. Promethazine alone had no adverse effect, but combined with spinning, decreased Acc and speed. Lorazepam alone decreased speed, and with spinning, decreased Ace. The data suggest that, at clinically useful doses, the rank order of the drugs with the best cognitive profiles is meclizine>scopolamine>promethazine>lorazepam. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - space motion sickness
KW - working memory
KW - gravity environments
KW - space flight
KW - cognitive function
KW - 2004
KW - Cognitive Ability
KW - Gravitational Effects
KW - Motion Sickness
KW - Short Term Memory
KW - Spaceflight
KW - Drug Therapy
KW - Teratogens
KW - Weightlessness
KW - 2004
DO - 10.1016/j.ntt.2004.07.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-19767-012&site=ehost-live&scope=site
UR - mpaule@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20489-002
AN - 2004-20489-002
AU - Jones, Danson R.
AU - Macias, Cathaleene
AU - Barreira, Paul J.
AU - Fisher, William H.
AU - Hargreaves, William A.
AU - Harding, Courtenay M.
T1 - Prevalence, severity, and co-occurrence of chronic physical health problems of persons with serious mental illness.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2004/11//
VL - 55
IS - 11
SP - 1250
EP - 1257
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Jones, Danson R., Department of Community Intervention Research, McLean Hospital, 115 Mill Street, Belmont, MA, US, 02478-9106
N1 - Accession Number: 2004-20489-002. PMID: 15534013 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Jones, Danson R.; Department of Community Intervention Research, McLean Hospital, Belmont, MA, US. Release Date: 20041206. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Illness; Epidemiology; Mental Disorders; Physical Disorders; Physical Health. Minor Descriptor: Comorbidity; Severity (Disorders). Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Positive and Negative Syndrome Scale DOI: 10.1037/t05056-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2004.
AB - Objectives: This study examined Medicaid claims forms to determine the prevalence, severity, and co-occurrence of physical illness within a representative sample of persons with serious mental illness (N= 147). Methods: Representativeness of health problems in the study sample was established through comparison with a larger sample of persons with serious mental illness enrolled in Medicaid within the same state. Standardized annual costs were then assigned to Medicaid claims diagnoses, and individual health problem severity was measured as the sum of estimated treatment costs for diagnosed conditions. Results: Seventy-four percent of the study sample (N= 109) had been given a diagnosis of at least one chronic health problem, and 50 percent (N=73) had been given a diagnosis of two or more chronic health problems. Of the 14 chronic health conditions surveyed, chronic pulmonary illness was the most prevalent (31 percent incidence) and the most comorbid. Persons with chronic pulmonary illness were second only to those with infectious diseases in average annual cost of treatment ($8,277). Also, 50 percent or more of participants in eight other diagnostic categories had chronic pulmonary illness. A regression analysis identified age, obesity, and substance use disorders as significant predictors of individual health problem severity. Conclusions: Risk adjustment for physical health is essential when setting performance standards or cost expectations for mental health treatment. Excluding persons with chronic health problems from mental health service evaluations restricts generalizability of research findings and may promote interventions that are inappropriate for many persons with serious mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chronic physical health problems
KW - mental illness
KW - severity
KW - 2004
KW - Chronic Illness
KW - Epidemiology
KW - Mental Disorders
KW - Physical Disorders
KW - Physical Health
KW - Comorbidity
KW - Severity (Disorders)
KW - 2004
DO - 10.1176/appi.ps.55.11.1250
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20489-002&site=ehost-live&scope=site
UR - djones@mclean.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Calonge, Ned
AU - Randhawa, Gurvaneet
T1 - The Meaning of the U.S. Preventive Services Task Force Grade I Recommendation: Screening for Hepatitis C Virus Infection.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2004/11/02/
VL - 141
IS - 9
M3 - Article
SP - 718
EP - 719
SN - 00034819
AB - The U.S. Preventive Services Task Force (USPSTF) formulates evidence-based recommendations for clinical preventive services. These recommendations are communicated by letter grades that reflect the quality of evidence and the magnitude of net health benefit expected from delivering the preventive service. When the USPSTF finds insufficient evidence to determine the balance of health benefits or harms of delivering a preventive service, because of a lack of studies, poor-quality studies, or good-quality studies with conflicting results, the USPSTF assigns the service an I letter grade. The USPSTF found insufficient evidence to recommend for or against screening for hepatitis C virus infection in high-risk individuals (I letter grade). This recommendation reflects the need for further research that would provide adequate evidence to assess the net health benefit for persons screened for hepatitis C virus infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL hepatitis
KW - MEDICAL care
KW - HEPATITIS C virus
KW - VIRUS diseases
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 14941194; Calonge, Ned 1 Randhawa, Gurvaneet 2; Affiliation: 1: Colorado Department of Public Health and Environment, Denver, Colorado. 2: Agency for Healthcare Research and Quality, Rockville, Maryland.; Source Info: 11/2/2004, Vol. 141 Issue 9, p718; Subject Term: VIRAL hepatitis; Subject Term: MEDICAL care; Subject Term: HEPATITIS C virus; Subject Term: VIRUS diseases; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14941194&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Powers, J. H.
T1 - Antimicrobial drug development– the past, the present, and the future.
JO - Clinical Microbiology & Infection
JF - Clinical Microbiology & Infection
Y1 - 2004/11/02/Nov2004 Supplement 4
VL - 10
M3 - Article
SP - 23
EP - 31
PB - Elsevier Science
SN - 1198743X
AB - Antimicrobial resistance has been an issue since the introduction into clinical use of the first agents in the 1940s. Although the discovery and development of new classes of antimicrobials through the 1960s presented an array of treatment options, these options for some serious and life-threatening infectious diseases may now be more limited. This paper examines the history of antimicrobial development, showing how the challenges in discovering new classes of drugs have been with us for the last 40 years. The present state of antimicrobial discovery and development is shaped by these challenges as well as by the economic realities of the pharmaceutical industry. This paper also discusses some of the regulatory considerations in antimicrobial drug development, and presents some potential solutions to the challenges inherent in antimicrobial drug development, including steps taken by the US Food and Drug Administration to streamline the drug review process for antimicrobial agents while maintaining the standards necessary to protect and promote the health of the public. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Microbiology & Infection is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Drug development
KW - Pharmaceutical industry
KW - Drug resistance in microorganisms
KW - Pharmaceutical policy
KW - Drug approval
KW - Antimicrobial resistance
KW - clinical trials
KW - drug design
KW - drug development
N1 - Accession Number: 14763289; Powers, J. H. 1; Email Address: POWERSJOH@cder.fda.gov; Affiliations: 1: US Food and Drug Administration, Rockville, MD, USA; Issue Info: Nov2004 Supplement 4, Vol. 10, p23; Thesaurus Term: Anti-infective agents; Subject Term: Drug development; Subject Term: Pharmaceutical industry; Subject Term: Drug resistance in microorganisms; Subject Term: Pharmaceutical policy; Subject Term: Drug approval; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: drug design; Author-Supplied Keyword: drug development; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1465-0691.2004.1007.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=14763289&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Prikhod'ko, Elena A.
AU - Prikhod'ko, Grigori G.
AU - Siegel, Richard M.
AU - Thompson, Peter
AU - Major, Marian E.
AU - Cohen, Jeffrey I.
T1 - The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities
JO - Virology
JF - Virology
Y1 - 2004/11/10/
VL - 329
IS - 1
M3 - Article
SP - 53
EP - 67
SN - 00426822
AB - Apoptosis has been implicated in the pathogenesis of hepatitis C virus (HCV)-related disease. Here, we show that expression of HCV NS3, or the NS2/NS3 precursor protein, in mammalian cells results in induction of apoptosis and activation of caspases. HCV NS3-induced apoptosis was blocked by a caspase-8, but not a caspase-9-specific inhibitor. HCV NS3 coimmunoprecipitated with caspase-8, but not with other caspases or with FADD. Coexpression of HCV NS3 and caspase-8 resulted in aggregation of the caspase in punctate structures that colocalized with HCV NS3. Cell lines stably expressing low levels HCV NS3 showed increased sensitivity to Fas-induced cell death. Point mutations of NS3 showed that the pro-apoptotic function of the protein is distinct from its protease and helicase activities. These findings suggest that HCV NS3 promotes caspase-8 induced apoptosis at a pathway site distal to FADD, and that flavivirus NS3 may represent a new class of pro-apoptotic proteins. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C
KW - APOPTOSIS
KW - HEPATITIS C virus
KW - FLAVIVIRUSES
KW - Apoptosis
KW - Caspase-8
KW - Flavivirus
KW - Hepatitis C virus
N1 - Accession Number: 14680662; Prikhod'ko, Elena A. 1 Prikhod'ko, Grigori G. 2 Siegel, Richard M. 3 Thompson, Peter 4 Major, Marian E. 4 Cohen, Jeffrey I.; Email Address: jcohen@niaid.nih.gov; Affiliation: 1: Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 2: Plasma Derivatives Department, American Red Cross, Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA 3: Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4: Laboratory of Hepatitis Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Nov2004, Vol. 329 Issue 1, p53; Subject Term: HEPATITIS C; Subject Term: APOPTOSIS; Subject Term: HEPATITIS C virus; Subject Term: FLAVIVIRUSES; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Caspase-8; Author-Supplied Keyword: Flavivirus; Author-Supplied Keyword: Hepatitis C virus; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.virol.2004.08.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14680662&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - O’Brien, Charles P.
AU - Charney, Dennis S.
AU - Lewis, Lydia
AU - Cornish, James W.
AU - Post, Robert M.
AU - Woody, George E.
AU - Zubieta, Jon-Kar
AU - Anthony, James C.
AU - Blaine, Jack D.
AU - Bowden, Charles L.
AU - Calabrese, Joseph R.
AU - Carroll, Kathleen
AU - Kosten, Thomas
AU - Rounsaville, Bruce
AU - Childress, Anna Rose
AU - Oslin, David W.
AU - Pettinati, Helen M.
AU - Davis, Mark A.
AU - DeMartino, Robert
AU - Drake, Robert E.
T1 - Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: A call to action
JO - Biological Psychiatry
JF - Biological Psychiatry
Y1 - 2004/11/15/
VL - 56
IS - 10
M3 - Editorial
SP - 703
EP - 713
SN - 00063223
N1 - Accession Number: 15448958; O’Brien, Charles P. 1; Email Address: obrien@mail.trc.upenn.edu Charney, Dennis S. 2 Lewis, Lydia 3 Cornish, James W. 4 Post, Robert M. 5 Woody, George E. 4 Zubieta, Jon-Kar 6 Anthony, James C. 7 Blaine, Jack D. 8 Bowden, Charles L. 9 Calabrese, Joseph R. 10 Carroll, Kathleen 11 Kosten, Thomas 11 Rounsaville, Bruce 11 Childress, Anna Rose 4 Oslin, David W. 4 Pettinati, Helen M. 4 Davis, Mark A. 12 DeMartino, Robert 13 Drake, Robert E. 14; Affiliation: 1: Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104-6178, 2: Mount Sinai School of Medicine, New York, New York 3: Depression and Bipolar Support Alliance, Chicago, Illinois 4: VAMC-Mental Illness Research, Education and Clinical Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 5: National Institute of Mental Health, Bethesda, Maryland 6: University of Michigan, Ann Arbor, Michigan 7: Michigan State University, East Lansing, Michigan 8: Biopharmaceutical Research Consultants, Inc., Ann Arbor, Michigan 9: University of Texas Health Science Center at San Antonio, San Antonio, Texas 10: Case Western Reserve University School of Medicine, Cleveland, Ohio 11: Yale University School of Medicine, New Haven, Connecticut 12: Depression and Bipolar Support Alliance Pink and Blues, Philadelphia, Pennsylvania 13: Substance Abuse and Mental Health Services Administration, Washington, DC 14: Dartmouth Medical School, Hanover, New Hampshire; Source Info: Nov2004, Vol. 56 Issue 10, p703; Number of Pages: 11p; Document Type: Editorial
L3 - 10.1016/j.biopsych.2004.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15448958&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Paul
AU - Rau, Edward H.
AU - Lemieux, Paul
AU - Johnson, Bruce K.
AU - Bacote, Alfred E.
AU - Gajdusek, D. Carleton
T1 - Infectivity Studies of Both Ash and Air Emissions from Simulated Contaminated Tissues.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2004/11/15/
VL - 38
IS - 22
M3 - Article
SP - 6156
EP - 6160
SN - 0013936X
AB - We investigated the effectiveness of 15 mm exposures to 600 and 1000 °C in continuous flow normal and starved- air incineration-like conditions to inactivate samples of pooled brain macerates from hamsters infected with the 263K strain of hamster-adapted scrapie with an infectivity titer in excess of 109 mean lethal doses (LD50) per g. Bioassays of the ash, outflow tubing residues, and vented emissions from heating 1 g of tissue samples yielded a total of two transmissions among 21 inoculated animals from the ash of a single specimen burned in normal air at 600 °C. No other ash, residue, or emission from samples heated at either 600 or 1000 °C, under either normal or starved-air conditions, transmitted disease. We conclude that at temperatures approaching 1000 °C under the air conditions and combustion times used in these experiments, contaminated tissues can be completely inactivated, with no release of infectivity into the environment from emissions. The extent to which this result can be realized in actual incinerators and other combustion devices will depend on equipment design and operating conditions during the heating process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Hamsters
KW - Muridae
KW - Biological assay
KW - Tissues
KW - Scrapie
N1 - Accession Number: 15272950; Brown, Paul 1; Email Address: paulwbrown@comcast.net; Rau, Edward H. 2; Lemieux, Paul 3; Johnson, Bruce K. 1; Bacote, Alfred E. 1; Gajdusek, D. Carleton 4; Affiliations: 1: Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke,; 2: Division of Environmental Protection, Office of Research Facilities Development and Operations, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892.; 3: National Homeland Security Research Center, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711.; 4: Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France.; Issue Info: 11/15/2004, Vol. 38 Issue 22, p6156; Thesaurus Term: Air pollution; Thesaurus Term: Hamsters; Thesaurus Term: Muridae; Thesaurus Term: Biological assay; Subject Term: Tissues; Subject Term: Scrapie; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15272950&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wulfkuhle, Julia
AU - Espina, Virginia
AU - Liotta, Lance
AU - Petricoin, Emanuel
T1 - Genomic and proteomic technologies for individualisation and improvement of cancer treatment
JO - European Journal of Cancer
JF - European Journal of Cancer
Y1 - 2004/11/15/
VL - 40
IS - 17
M3 - Article
SP - 2623
EP - 2632
SN - 09598049
AB - The development of microarray-based technologies for characterising tumours, both at the genomic and proteomic levels, has had a significant impact on the field of oncology. Gene expression profiling of various human tumour tissues has led to the identification of expression patterns related to disease outcome and drug resistance, as well as to the discovery of new therapeutic targets and insights into disease pathogenesis. Protein microarray technologies, such as reverse-phase protein arrays, provide the unique opportunity to profile tissues and assess the activity of signalling pathways within isolated cell populations. This technology can be used to identify patients likely to benefit from specific treatment modalities and also to monitor therapeutic response in samples obtained during and after treatment. Routine application of genomic and proteomic microarray technologies in clinical practice will require significant efforts to standardise the techniques, controls and reference standards, and analytical tools used. Extensive, independent validation using large, statistically-powered datasets will also be necessary. Inclusion of concomitant genomic and proteomic-based molecular profiling techniques into clinical trial protocols will bring us closer to the reality of patient-tailored therapy. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - GENETICS
KW - TUMORS
KW - CELL proliferation
KW - Cancer
KW - Genomics
KW - Individual targeted therapy
KW - Microarrays
KW - Molecular profiling
KW - Protein microarrays
KW - Proteomics
KW - Cancer
N1 - Accession Number: 15800280; Wulfkuhle, Julia 1; Email Address: wulfkuhle@cber.fda.gov Espina, Virginia 1 Liotta, Lance 1 Petricoin, Emanuel 2; Affiliation: 1: NCI/FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bldg. 29A/2B20, HFM 710, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: NCI/FDA Clinical Proteomics Program, Office of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Nov2004, Vol. 40 Issue 17, p2623; Subject Term: CANCER treatment; Subject Term: GENETICS; Subject Term: TUMORS; Subject Term: CELL proliferation; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Genomics; Author-Supplied Keyword: Individual targeted therapy; Author-Supplied Keyword: Microarrays; Author-Supplied Keyword: Molecular profiling; Author-Supplied Keyword: Protein microarrays; Author-Supplied Keyword: Proteomics; Author-Supplied Keyword: Cancer; Language of Keywords: English; Language of Keywords: French; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ejca.2004.05.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15800280&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106492253
T1 - Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration.
AU - Talarico L
AU - Chen G
AU - Pazdur R
Y1 - 2004/11/15/
N1 - Accession Number: 106492253. Language: English. Entry Date: 20050729. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Clinical Trials
KW - Patient Selection
KW - United States Food and Drug Administration
KW - Age Factors
KW - Neoplasms -- Therapy
KW - Retrospective Design
KW - Aged
KW - Aged, 80 and Over
KW - Human
SP - 4626
EP - 4631
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 22
IS - 22
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - PURPOSE: To analyze the age-related enrollment of cancer patients onto registration trials of new drugs or new indications approved by the US Food and Drug Administration from 1995 to 2002. PATIENTS AND METHODS: This study involved retrospective analyses of demographic data of cancer patients enrolled onto registration trials. The data on 28,766 cancer patients from 55 registration trials were analyzed according to age distributions of > or = 65, > or = 70, and > or = 75 years. The rates of enrollment in each age group for each cancer were compared with the corresponding rates in the US cancer population. The age distributions of the US cancer population were derived from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute for the period 1995 to 1999 based on the 2000 US Census. RESULTS: The proportions of the overall patient populations aged > or = 65, > or = 70, and > or = 75 years were 36%, 20%, and 9% compared with 60%, 46%, and 31%, respectively, in the US cancer population. Statistically significant under-representation of the elderly (P < .001) was noted in registration trials for all cancer treatment except for breast cancer hormonal therapies. Patients aged > or = 70 years accounted for most of the under-representation. CONCLUSION: Elderly were under-represented in the registration trials of new cancer therapies. Various strategies may be needed to evaluate cancer therapies for the elderly in prospective clinical trials and to improve cancer care in the elderly population.
SN - 0732-183X
AD - Division of Oncology Drug Products, HFD 150, Food and Drug Administration, 1451 Rockville Pike, Rockville, MD 20857; Talarico@cder.fda.gov
U2 - PMID: 15542812.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gratz, Samuel R.
AU - Flurer, Cheryl L.
AU - Wolnik, Karen A.
T1 - Analysis of undeclared synthetic phosphodiesterase-5 inhibitors in dietary supplements and herbal matrices by LC–ESI–MS and LC–UV
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2004/11/15/
VL - 36
IS - 3
M3 - Article
SP - 525
EP - 533
SN - 07317085
AB - A liquid chromatography–electrospray ionisation–mass spectrometry (LC–ESI–MS) method was developed to screen for the presence of synthetic phosphodiesterase type 5 (PDE-5) inhibitors including sildenafil, tadalafil and vardenafil. The method was applied to the analysis of dietary supplements and bulk herbal materials. Bulk powders or composites of tablets, capsules or liquids were prepared and an extraction of PDE-5 inhibitors was performed using a mixture of acetonitrile and water with sonication. Identification of sildenafil, vardenafil or tadalafil was accomplished using a single quadrupole mass spectrometer coupled to a liquid chromatograph with an electrospray interface. Positive ion detection in the full scan mode was used while in-source collision induced dissociation (CID) provided several structurally significant fragment ions to aid in the mass spectral identification. Approximately half of the 40 botanical products analyzed were found to contain undeclared synthetic PDE-5 inhibitors. For products found to contain one of these three compounds by LC–MS, HPLC with UV detection was used for quantitation. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILDENAFIL
KW - CYCLIC nucleotide phosphodiesterases -- Inhibitors
KW - MASS spectrometry
KW - ELECTROSPRAY ionization mass spectrometry
KW - Dietary supplements
KW - Electrospray
KW - Mass spectrometry
KW - Phosphodiesterase-5
KW - Reversed-phase liquid chromatography
KW - Sildenafil
KW - Tadalafil
KW - Vardenafil
N1 - Accession Number: 14873050; Gratz, Samuel R.; Email Address: sgratz@ora.fda.gov Flurer, Cheryl L. 1 Wolnik, Karen A. 1; Affiliation: 1: US Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237-3097, USA; Source Info: Nov2004, Vol. 36 Issue 3, p525; Subject Term: SILDENAFIL; Subject Term: CYCLIC nucleotide phosphodiesterases -- Inhibitors; Subject Term: MASS spectrometry; Subject Term: ELECTROSPRAY ionization mass spectrometry; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Electrospray; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Phosphodiesterase-5; Author-Supplied Keyword: Reversed-phase liquid chromatography; Author-Supplied Keyword: Sildenafil; Author-Supplied Keyword: Tadalafil; Author-Supplied Keyword: Vardenafil; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jpba.2004.07.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mackey, E.A.
AU - Anderson, D.L.
AU - Liposky, P.J.
AU - Lindstrom, R.M.
AU - Chen-Mayer, H.
AU - Lamaze, G.P.
T1 - New thermal neutron prompt γ-ray activation analysis instrument at the National Institute of Standards and Technology Center for Neutron Research
JO - Nuclear Instruments & Methods in Physics Research Section B
JF - Nuclear Instruments & Methods in Physics Research Section B
Y1 - 2004/11/15/
VL - 226
IS - 3
M3 - Article
SP - 426
EP - 440
SN - 0168583X
AB - A new thermal neutron prompt γ-ray activation analysis (PGAA) instrument was designed and built to replace the original PGAA system at the NIST Center for Neutron Research. By placing a sapphire filter in the neutron beam shutter assembly, the fast neutron fluence rate was reduced by a factor of 5 and low-energy (50–200 keV) γ-ray intensities were reduced by factors of 5–10. The thermal neutron fluence rate was reduced by only a factor of 1.13. A new external beam tube, sample chamber, beam stop, and support structure were built and a new detection system installed. The new beam tube is made of two cylindrical aluminum sections lined with a lithiated polymer. Both sections are kept under vacuum to reduce the number of neutrons scattered by air into the beam tube walls. The sample chamber is also fabricated from aluminum and lined with lithiated polymer, and may be evacuated to minimize the number of neutrons scattered and absorbed by air. The beam tube and sample chamber assembly is suspended from the aluminum support structure. The detection system consists of a 40% efficient (relative) germanium detector (resolution 2.0 at 1332.5 keV) and a bismuth germanate Compton suppressor. The detection system is shielded by lead, surrounded by borated and lithiated polyethylene, and placed on a table attached to the support structure. The new, more compact beam stop is welded to the support structure. Capture γ-ray photopeaks from H, B, C, N, Na, Al, Fe, Ge, I and Pb in the background spectrum were either of lower intensity or eliminated with the new PGAA instrument. The more efficient detection system, positioned closer to the sample, yielded element sensitivity increases of 5–50%. Limits of detection have been greatly reduced compared with those of the original instrument due to reduced Compton and scattered γ-ray backgrounds (especially in the low-energy region), increased sensitivities, and reduction of background γ-ray photopeak intensities. [Copyright &y& Elsevier]
AB - Copyright of Nuclear Instruments & Methods in Physics Research Section B is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR reactors
KW - NATIVE element minerals
KW - SEALING (Technology)
KW - SOLDER & soldering
KW - BLACKSMITHING
KW - γ-Ray spectrometry
KW - Neutron beam
KW - Neutron capture
KW - Prompt gamma activation analysis
KW - Prompt gamma-rays
N1 - Accession Number: 14812134; Mackey, E.A. 1; Email Address: lmackey@nist.gov Anderson, D.L. 2 Liposky, P.J. 3 Lindstrom, R.M. 1 Chen-Mayer, H. 1 Lamaze, G.P. 1; Affiliation: 1: Analytical Chemistry Division, National Institute of Standards and Technology, 100 Bureau Dr., Gaithersburg, MD 20899-8395, USA 2: US Food and Drug Administration, Elemental Research Branch, College Park, MD 20740-3835, USA 3: Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-8561, USA; Source Info: Nov2004, Vol. 226 Issue 3, p426; Subject Term: NUCLEAR reactors; Subject Term: NATIVE element minerals; Subject Term: SEALING (Technology); Subject Term: SOLDER & soldering; Subject Term: BLACKSMITHING; Author-Supplied Keyword: γ-Ray spectrometry; Author-Supplied Keyword: Neutron beam; Author-Supplied Keyword: Neutron capture; Author-Supplied Keyword: Prompt gamma activation analysis; Author-Supplied Keyword: Prompt gamma-rays; NAICS/Industry Codes: 332410 Power Boiler and Heat Exchanger Manufacturing; NAICS/Industry Codes: 333992 Welding and Soldering Equipment Manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.nimb.2004.05.038
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14812134&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horne, Amelia Dale
AU - Clifford, Julianne
AU - Goldenthal, Karen L.
AU - Kleppinger, Cynthia
AU - Lachenbruch, Peter A.
T1 - Preventive vaccines against bioterrorism: evaluation of efficacy and safety
JO - Vaccine
JF - Vaccine
Y1 - 2004/11/15/
VL - 23
IS - 1
M3 - Article
SP - 84
EP - 90
SN - 0264410X
AB - This paper discusses the US Food and Drug Administration’s approach to evaluation of vaccines in general, and vaccines against diseases of bioterrorism in particular. We summarize the scientific bases for development and approval of vaccines and then discuss specific issues regarding vaccines against disease organisms that could potentially be used as weapons of bioterrorism. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Bioterrorism
KW - Terrorism
KW - Vaccines
KW - Animal Rule
KW - Copper cryptates
KW - Fluorescent probes
KW - Glutamate
KW - Immunogenicity
KW - Non-inferiority
N1 - Accession Number: 14870876; Horne, Amelia Dale; Email Address: horne@cber.fda.gov; Clifford, Julianne 1; Goldenthal, Karen L. 1; Kleppinger, Cynthia 2; Lachenbruch, Peter A. 3; Affiliations: 1: Division of Vaccines and Related Products Applications, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, MD, USA; 2: Center for Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, USA; 3: Division of Biostatistics, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research (CBER), FDA, HFM-217, 1401 Rockville Pike, Rockville, MD 20852-1448, USA; Issue Info: Nov2004, Vol. 23 Issue 1, p84; Thesaurus Term: Vaccination; Thesaurus Term: Bioterrorism; Subject Term: Terrorism; Subject Term: Vaccines; Author-Supplied Keyword: Animal Rule; Author-Supplied Keyword: Copper cryptates; Author-Supplied Keyword: Fluorescent probes; Author-Supplied Keyword: Glutamate; Author-Supplied Keyword: Immunogenicity; Author-Supplied Keyword: Non-inferiority; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.04.037
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ioannidis, John P.A.
AU - Evans, Stephen J. W.
AU - Gøtzsche, Peter C.
AU - O'Neill, Robert T.
AU - Altman, Douglas G.
AU - Schulz, Kenneth
AU - Moher, David
T1 - Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2004/11/16/
VL - 141
IS - 10
M3 - Article
SP - 781
EP - W-151
SN - 00034819
AB - In response to overwhelming evidence and the consequences of poor-quality reporting of randomized, controlled trials (RCTs), many medical journals and editorial groups have now endorsed the CONSORT (Consolidated Standards of Reporting Trials) statement, a 22-item checklist and flow diagram. Because CONSORT primarily aimed at improving the quality of reporting of efficacy, only 1 checklist item specifically addressed the reporting of safety. Considerable evidence suggests that reporting of harmsrelated data from RCTs also needs improvement. Members of the CONSORT Group, including journal editors and scientists, met in Montebello, Quebec, Canada, in May 2003 to address this problem. The result is the following document: the standard CONSORT checklist with 10 new recommendations about reporting harms-related issues, accompanying explanation, and examples to highlight specific aspects of proper reporting. We hope that this document, in conjunction with other CONSORT-related materials (www.consort-statement.org), will help authors improve their reporting of harms-related data from RCTs. Better reporting will help readers critically appraise and interpret trial results. Journals can support this goal by revising Instructions to Authors so that they refer authors to this document. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - DRUGS -- Effectiveness
KW - QUALITY
KW - QUALITY assurance
KW - GOAL (Psychology)
KW - SCIENTISTS
N1 - Accession Number: 15155074; Ioannidis, John P.A. 1 Evans, Stephen J. W. 2 Gøtzsche, Peter C. 3 O'Neill, Robert T. 4 Altman, Douglas G. 5 Schulz, Kenneth 6 Moher, David 7; Email Address: dmoher@uottawa.ca; Affiliation: 1: Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece. 2: Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. 3: The Nordic Cochrane Centre, Rigshospitalet, Department 7112, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. 4: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857. 5: Cancer Research UK/NHS Centre for Statistics in Medicine, Old Road Campus, Old Road, Headington, Oxford OX3 7LF, United Kingdom. 6: Family Health International, PO Box 13950, Research Triangle Park, NC 27709. 7: Chalmers Research Group, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada.; Source Info: 11/16/2004, Vol. 141 Issue 10, p781; Subject Term: CLINICAL trials; Subject Term: DRUGS -- Effectiveness; Subject Term: QUALITY; Subject Term: QUALITY assurance; Subject Term: GOAL (Psychology); Subject Term: SCIENTISTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobs, Elizabeth T.
AU - Jiang, Ruiyun
AU - Alberts, David S.
AU - Greenberg, E. Robert
AU - Gunter, Elaine W.
AU - Karagas, Margaret R.
AU - Lanza, Elaine
AU - Ratnasinghe, Luke
AU - Reid, Mary E.
AU - Schatzkin, Arthur
AU - Smith-Warner, Stephanie A.
AU - Wallace, Kristin
AU - Martinez, Maria Elena
T1 - Selenium and Colorectal Adenoma: Results of a Pooled Analysis.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2004/11/17/
VL - 96
IS - 22
M3 - Article
SP - 1669
EP - 1675
SN - 00278874
AB - Background: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. Methods: We conducted a combined analysis of data from three randomized trials—the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study—which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (Cis) were calculated using logistic regression modeling. All statistical tests were two-sided. Results: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67,95% CI = 0.43 to 1.05; Ptrend = .21; Wheat Bran Fiber Trial: OR = 0.66,95% CI = 0.40 to 1.10; Ptrend = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, Ptrend = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95 % CI = 0.50 to 087; Ptrend = .006). Conclusions: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer -- Risk factors
KW - CANCER -- Risk factors
KW - SELENIUM -- Physiological effect
KW - MINERALS in the body
KW - CANCER research
KW - DISEASES -- Risk factors
N1 - Accession Number: 15320552; Jacobs, Elizabeth T. 1,2; Email Address: jacobse@u.arizona.edu Jiang, Ruiyun 1 Alberts, David S. 1 Greenberg, E. Robert 3 Gunter, Elaine W. 4 Karagas, Margaret R. 3 Lanza, Elaine 5 Ratnasinghe, Luke 6 Reid, Mary E. 7 Schatzkin, Arthur 5 Smith-Warner, Stephanie A. 8 Wallace, Kristin 3 Martinez, Maria Elena 3; Affiliation: 1: Arizona Cancer Center, University of Arizona, Tucson 2: Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson 3: Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 4: Centers for Disease Control and Prevention, Atlanta, GA 5: National Cancer is institute, Bethesda, MD 6: Food and Drug Administration, Jefferson, AR 7: Roswell Park Cancer Institute, Buffalo, NY 8: Harvard School of Public Health, Boston, MA; Source Info: 11/17/2004, Vol. 96 Issue 22, p1669; Subject Term: COLON cancer -- Risk factors; Subject Term: CANCER -- Risk factors; Subject Term: SELENIUM -- Physiological effect; Subject Term: MINERALS in the body; Subject Term: CANCER research; Subject Term: DISEASES -- Risk factors; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kibler, Karen V.
AU - Miyazato, Akiko
AU - Yedavalli, Venkat S. R. K.
AU - Dayton, Andrew I.
AU - Jacobs, Bertram L.
AU - Dapolito, George
AU - Seong-jin Kim
AU - Kuan-Teh Jeang
T1 - Polyarginine Inhibits gp160 Processing by Furin and Suppresses Productive Human Immunodeficiency Virus Type 1 Infection.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/11/19/
VL - 279
IS - 47
M3 - Article
SP - 49055
EP - 49063
SN - 00219258
AB - Correct endoproteolytic maturation of gp160 is essential for the infectivity of human immunodeficiency virus type 1. This processing of human immunodeficiency virus-1 envelope protein, gp160, into gp120 and gp41 has been attributed to the activity of the cellular subtilisin-like proprotein convertase furin. The prototypic furin recognition cleavage site is Arg-X-Arg/Lys-Arg. Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin. Here, we tested polyarginine for inhibition of productive human immunodeficiency virus-1-infection in T-cell lines, primary peripheral blood mononuclear cells, and macrophages. We found that polyarginine inhibited significantly human immunodeficiency virus-1 replication at concentrations that were benign to cell cultures ex vivo and mice in vivo. Using a fluorogenic assay, we demonstrated that polyarginine potently inhibited substrate-specific proteolytic cleavage by furin. Moreover, we verified that authentic processing of human immunodeficiency virus-1 gp160 synthesized in human cells from an infectious human immunodeficiency virus-1 (HIV-1) molecular clone was effectively blocked by polyarginine. Taken together, our data support that inhibitors of proteolytic processing of gp160 may be useful for combating human immunodeficiency virus-1 and that polyarginine represents a lead example of such inhibitors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARGININE
KW - HIV infections
KW - T cells
KW - VIRAL replication
KW - VIRAL proteins
KW - MOLECULAR cloning
KW - BIOCHEMISTRY
N1 - Accession Number: 15370470; Kibler, Karen V. 1 Miyazato, Akiko 1 Yedavalli, Venkat S. R. K. 1 Dayton, Andrew I. 2 Jacobs, Bertram L. 3 Dapolito, George 1 Seong-jin Kim 4 Kuan-Teh Jeang 1; Email Address: kj7e@nih.gov; Affiliation: 1: Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 208920460 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892-0460 3: Biodesign Institute, Center for Infectious Disease and Vaccinology, Arizona State University, Tempe, Arizona 85287 4: Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892-0460; Source Info: 11/19/2004, Vol. 279 Issue 47, p49055; Subject Term: ARGININE; Subject Term: HIV infections; Subject Term: T cells; Subject Term: VIRAL replication; Subject Term: VIRAL proteins; Subject Term: MOLECULAR cloning; Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Illustrations: 11 Graphs; Document Type: Article
L3 - 10.1074/jbc.M403394200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weisz, Adrian
AU - Andrzejewski, Denis
AU - Rasooly, Irit R.
T1 - Determination of 2,4,6-tribromoaniline in the color additives D&C Red Nos. 21 and 22 (Eosin Y) using solid-phase microextraction and gas chromatography-mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2004/11/19/
VL - 1057
IS - 1/2
M3 - Article
SP - 185
EP - 191
SN - 00219673
AB - The present work demonstrates the presence of an impurity, 2,4,6-tribromoaniline (TBA), in the color additives D&C Red Nos. 21 and 21 lake (21L) and describes the determination of TBA in certified lots of D&C Red Nos. 21, 21L and 22 (Eosin Y). A method was developed using solid-phase microextraction with [13C6]TBA as an internal standard followed by gas chromatography-mass spectrometry analysis. Test portions from 23 lots of US-certified color additives D&C Red Nos. 21, 21L and 22 were analyzed for TBA using the new method. These lots represent domestic (four) and foreign (four) manufacturers that requested certification for the color additives during the past 2 years. Of the test portions analyzed, 12 (52.2%) contained TBA in amounts ranging from 19.9 to 638.9ppm with an average value of ∼278.7ppm. The remaining 11 (47.2%) test portions contained no detectable TBA or less than 0.01ppm, which is the limit of quantification of the present method. The wide range of TBA levels found in lots submitted for certification suggest that the contamination with TBA may be avoided or significantly decreased through appropriate changes in the color-manufacturing process. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gas chromatography
KW - Additives
KW - Solid phase extraction
KW - Mass spectrometry
KW - 2,4,6-Tribromoaniline
KW - Aromatic amine
KW - Color additives
KW - D&C Red No. 21
KW - D&C Red No. 22
KW - D&C Red No. 21
KW - D&C Red No. 22
KW - Eosins
N1 - Accession Number: 14959258; Weisz, Adrian; Email Address: aweisz@cfsan.fda.gov; Andrzejewski, Denis 1; Rasooly, Irit R. 2; Affiliations: 1: Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; 2: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Chantilly, VA 20151, USA; Issue Info: Nov2004, Vol. 1057 Issue 1/2, p185; Thesaurus Term: Gas chromatography; Thesaurus Term: Additives; Thesaurus Term: Solid phase extraction; Thesaurus Term: Mass spectrometry; Author-Supplied Keyword: 2,4,6-Tribromoaniline; Author-Supplied Keyword: Aromatic amine; Author-Supplied Keyword: Color additives; Author-Supplied Keyword: D&C Red No. 21; Author-Supplied Keyword: D&C Red No. 22; Author-Supplied Keyword: D&C Red No. 21; Author-Supplied Keyword: D&C Red No. 22; Author-Supplied Keyword: Eosins; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.chroma.2004.09.065
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Kiley, Kevin C.
T1 - Military medicine and human rights.
JO - Lancet
JF - Lancet
Y1 - 2004/11/20/
VL - 364
IS - 9448
M3 - Letter
SP - 1851
EP - 1852
PB - Lancet
SN - 00995355
AB - Presents a letter to the editor in response to the article "Abu Graib: its legacy for military medicine," by Steven Miles in the August 21, 2004 issue.
KW - LETTERS to the editor
KW - MILITARY medicine
N1 - Accession Number: 15120593; Kiley, Kevin C. 1; Email Address: Virginia.stephanakis@otsg.amedd.army.mil; Affiliation: 1: Department of the Army, Office of the Surgeon General, 5109 Leesburg Pike Palls Church, VA 22041, USA; Source Info: 11/20/2004, Vol. 364 Issue 9448, p1851; Subject Term: LETTERS to the editor; Subject Term: MILITARY medicine; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - da Silva, Manuela
AU - Esposito, Elisa
AU - Moody, Joanna D.
AU - Canhos, Vanderlei P.
AU - Cerniglia, Carl E.
T1 - Metabolism of aromatic hydrocarbons by the filamentous fungus Cyclothyrium sp.
JO - Chemosphere
JF - Chemosphere
Y1 - 2004/11/22/
VL - 57
IS - 8
M3 - Article
SP - 943
EP - 952
SN - 00456535
AB - The metabolism of biphenyl, naphthalene, anthracene, phenanthrene, pyrene and benzo[a]pyrene by Cyclothyrium sp. CBS 109850, a coelomycete isolated for the first time in Brazil from industrially polluted estuarine sediment, was studied. The metabolites were extracted and separated by high performance liquid chromatography (HPLC) and characterized by UV spectral analyses and mass, and proton nuclear magnetic resonance (1H NMR) spectrometry. Cyclothyrium sp. transformed biphenyl to 4-hydroxybiphenyl and anthracene to anthracene trans-1,2-dihydrodiol. This isolate metabolized 90% of [9-14C]phenanthrene, producing phenanthrene trans-9,10-dihydrodiol as a major metabolite, phenanthrene trans-3,4-dihydrodiol, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 4-hydroxyphenanthrene, and a novel metabolite, 2-hydroxy-7-methoxyphenanthrene. Circular dichroism spectra analyses indicated that the major enantiomers of phenanthrene trans-9, 10-dihydrodiol, phenanthrene trans-3,4-dihydrodiol and pyrene trans-4,5-dihydrodiol, a pyrene metabolite produced previously by Cyclothyrium sp. CBS 109850, were predominantly in the (R,R) configuration, revealing a high stereoselectivity for initial monooxygenation and enzymatic hydration of phenanthrene and pyrene by Cyclothyrium sp. CBS109850. The results also show a high regioselectivity since the K-regions of phenanthrene and pyrene were the major sites of metabolism. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - HYDROCARBONS
KW - ORGANIC compounds
KW - NAPHTHALENE
KW - PYRENE (Chemical)
KW - COELOMYCETES
KW - Aromatic hydrocarbons
KW - Biotransformation
KW - Coelomycetes
KW - Fungi
KW - Pollutants
N1 - Accession Number: 14748542; da Silva, Manuela; Email Address: manuela@incqs.fiocruz.br Esposito, Elisa 1 Moody, Joanna D. 2 Canhos, Vanderlei P. 3 Cerniglia, Carl E. 2; Affiliation: 1: Department of Environmental Science, University of Mogi das Cruzes, 08780-911 Mogi das Cruzes, São Paulo, Brazil 2: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA 3: Department of Food Science, School of Food Engineering, State University of Campinas, 13083-970 Campinas, São Paulo, Brazil; Source Info: Nov2004, Vol. 57 Issue 8, p943; Subject Term: METABOLISM; Subject Term: HYDROCARBONS; Subject Term: ORGANIC compounds; Subject Term: NAPHTHALENE; Subject Term: PYRENE (Chemical); Subject Term: COELOMYCETES; Author-Supplied Keyword: Aromatic hydrocarbons; Author-Supplied Keyword: Biotransformation; Author-Supplied Keyword: Coelomycetes; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Pollutants; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chemosphere.2004.07.051
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hakimian, Rina
AU - Korn, David
T1 - Ownership and Use of Tissue Specimens for Research.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/11/24/
VL - 292
IS - 20
M3 - Article
SP - 2500
EP - 2505
SN - 00987484
AB - Academic and industrial scientists have sharply increased their demand for properly prepared and clinically annotated tissue samples that yield valuable insights into the origins and expressions of human disease. Historically, research on human tissue samples has been relatively unencumbered by federal regulations and occurred without delineation of ownership rights to the specimens, patient data, or research products. As regulations have become increasingly restrictive, and because clear ownership interests have never been established, the presumed right of researchers and institutions to collect, use, and dispose of specimens and their associated patient data has remained undefined and occasionally contentious. Recent examination of these issues by a US federal court resulted in a ruling that individuals do not retain rights of ownership or control of biological materials contributed for research, regardless of whether commercial benefit accrues. This article examines the legal, regulatory, and ethical framework within which human tissue research is currently conducted. We contend that because the benefits of medical knowledge derived from tissue research potentially accrue to all individuals and future generations (rather than a single recipient), society may justify an expansive use of these valuable resources for future studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUES
KW - RESEARCH
KW - RESEARCH -- Law & legislation
KW - DONATION of organs, tissues, etc.
KW - MEDICAL ethics
KW - BIOETHICS
KW - Ethics, Medical
KW - HEALTH LAW AND ETHICS (Gostin LO, Cole HM, eds)
KW - Jurisprudence
KW - Legislation
KW - Research
KW - Tissue Donors
N1 - Accession Number: 15149038; Hakimian, Rina 1,2 Korn, David 3; Email Address: dkorn@aamc.org; Affiliation: 1: Division of Biomedical and Health Sciences, Research, Association of American Medical Colleges, Washington DC 2: Office for Human Research Protections, US Department of Health and Human Services, Rockville, Md 3: Association of American Medical Colleges, 2450 N St NW, Washington DC, 20037; Source Info: 11/24/2004, Vol. 292 Issue 20, p2500; Subject Term: TISSUES; Subject Term: RESEARCH; Subject Term: RESEARCH -- Law & legislation; Subject Term: DONATION of organs, tissues, etc.; Subject Term: MEDICAL ethics; Subject Term: BIOETHICS; Author-Supplied Keyword: Ethics, Medical; Author-Supplied Keyword: HEALTH LAW AND ETHICS (Gostin LO, Cole HM, eds); Author-Supplied Keyword: Jurisprudence; Author-Supplied Keyword: Legislation; Author-Supplied Keyword: Research; Author-Supplied Keyword: Tissue Donors; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei, Nan
AU - Chou, Ming W.
AU - Fu, Peter P.
AU - Heflich, Robert H.
AU - Chen, Tao
T1 - Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/11/25/
VL - 215
IS - 2
M3 - Article
SP - 151
EP - 158
SN - 03043835
AB - Riddelliine is a naturally occurring pyrrolizidine alkaloid that induces liver hemangiosarcomas in rats and mice. We previously reported higher levels of DNA adducts in liver endothelial cells than in liver parenchymal cells of riddelliine-treated mice and rats [Cancer Lett. 193 (2003) 119], suggesting that the tumor specificity is due to higher levels of DNA damage in the cells that form hemangosarcomas. In the present study, we evaluated the cell-specificity of riddelliine mutagenicity in rat liver. Female transgenic Big Blue rats were treated by gavage with 0.3mg riddelliine per kg body weight, 5 days a week for 12 weeks. One day after the last treatment, the rats were sacrificed and liver parenchymal and endothelial cell fractions were isolated and purified. DNA was extracted from the cell fractions and used to assay for mutant frequency (MF) in the cII transgene. While there was no difference in the cII MFs of liver parenchymal cells in control and riddelliine-treated rats, the cII MF of liver endothelial cells from treated rats was significantly greater than the cII MF of endothelial cells from control rats. Molecular analysis of the mutants in liver endothelial cells indicated that G:C→T:A transversion, a mutation that is characteristically induced by riddelliine, accounted for only 9% of all mutations in control rats, but made up 17% of mutations in treated rats. In contrast, G:C→A:T transition, the major mutation in control rats where it made up 54% of all mutations, was reduced to 40% of mutations in riddelliine-treated rats. These results suggest that the relatively high mutagenicity of riddelliine in rat liver endothelial cells may be partially responsible for the tumorigenic specificity of this agent. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENICITY testing
KW - CELLS
KW - DNA
KW - LIVER
KW - cII gene
KW - Endothelial cell
KW - Hemangiosarcomas
KW - Pyrrolizidine alkaloid
KW - Riddelliine
KW - Transgenic rat
N1 - Accession Number: 14717292; Mei, Nan; Email Address: nmei@nctr.fda.gov Chou, Ming W. 1 Fu, Peter P. 1 Heflich, Robert H. 2 Chen, Tao 2; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Nov2004, Vol. 215 Issue 2, p151; Subject Term: MUTAGENICITY testing; Subject Term: CELLS; Subject Term: DNA; Subject Term: LIVER; Author-Supplied Keyword: cII gene; Author-Supplied Keyword: Endothelial cell; Author-Supplied Keyword: Hemangiosarcomas; Author-Supplied Keyword: Pyrrolizidine alkaloid; Author-Supplied Keyword: Riddelliine; Author-Supplied Keyword: Transgenic rat; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.canlet.2004.06.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - M. Oelbermann
AU - R.P. Voroney
AU - A.M. Schlönvoigt
AU - D.C.L. Kass
T1 - Decomposition of Erythrina poeppigiana leaves in 3-, 9-, and 18-year-old alleycropping systems in Costa Rica.
JO - Agroforestry Systems
JF - Agroforestry Systems
Y1 - 2004/12//
VL - 63
IS - 1
M3 - Article
SP - 27
EP - 32
SN - 01674366
AB - Timing the application of organic residues and therefore the release of nutrients during decomposition may be critical to the growing crop in tropical alleycropping agroforestry systems. Field experiments were carried out in Turrialba, Costa Rica, to determine differences in Erythrina poeppigiana (Walp.) O.F. Cook leaf decomposition in 3, 9 and 18-year alleycropped agroforestry systems. Treatments consisted of mulch-only, and mulch plus Arachis pintoi Krapov. and W. Gregory var. CIAT 18347 in 3 and 9-year old alleycrops under no-till cultivation. The 18-year old site consisted of treatments with mulch-only and mulch plus chicken manure under disk plow cultivation. Litterbags, filled with E. poeppigiana leaves from 3, 9 and 18-year old trees, were placed on the soil surface and collected over a period of 84 days. Results showed no significant differences in the amount of plant residues remaining after 84 days in the 3-, 9-, and 18-year-old systems, or between the manure and mulch-only treatments. Comparing mulch-only treatments, leaves in the 18-year old system decomposed most rapidly which may be due to disk-plow cultivation practices where litterbags were in direct contact with the soil as opposed to the no-till system in the younger alleycrops. [ABSTRACT FROM AUTHOR]
AB - Copyright of Agroforestry Systems is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Plant nutrients
KW - Erythrina
KW - Agroforestry
KW - Costa Rica
N1 - Accession Number: 21962777; M. Oelbermann 1; R.P. Voroney 2; A.M. Schlönvoigt 3,4; D.C.L. Kass 3,5; Affiliations: 1: University of Waterloo Department of Earth Sciences Waterloo ON N2L 3G1 ((phone Waterloo ON N2L 3G1 ((phone; 2: University of Guelph Department of Land Resource Science Guelph ON N1G 2W1 Canada Guelph ON N1G 2W1 Canada; 3: Area de Cuencas y Sistemas Agroforestales CATIE Apdo 7170 Turrialba Costa Rica CATIE Apdo 7170 Turrialba Costa Rica; 4: GFA Terra Systems Latin America Division Eulenkrugstrasse 82 22359 Hamburg Germany Eulenkrugstrasse 82 22359 Hamburg Germany; 5: Northeast Regional Laboratory, Food and Drug Administration Department of Health and Human Services 158-15 Liberty Avenue Jamaica NY 11433 158-15 Liberty Avenue Jamaica NY 11433; Issue Info: Dec2004, Vol. 63 Issue 1, p27; Thesaurus Term: Plant nutrients; Thesaurus Term: Erythrina; Thesaurus Term: Agroforestry; Subject: Costa Rica; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Oelbermann M.
AU - Voroney R.P.
AU - Schlönvoigt A.M.
AU - Kass D.C.L.
T1 - Decomposition of Erythrina poeppigiana leaves in 3-, 9-, and 18-year-old alleycropping systems in Costa Rica.
JO - Agroforestry Systems
JF - Agroforestry Systems
Y1 - 2004/12//
VL - 63
IS - 1
M3 - Article
SP - 27
EP - 32
SN - 01674366
AB - Timing the application of organic residues and therefore the release of nutrients during decomposition may be critical to the growing crop in tropical alleycropping agroforestry systems. Field experiments were carried out in Turrialba, Costa Rica, to determine differences in Erythrina poeppigiana (Walp.) O.F. Cook leaf decomposition in 3, 9 and 18-year alleycropped agroforestry systems. Treatments consisted of mulch-only, and mulch plus Arachis pintoi Krapov. and W. Gregory var. CIAT 18347 in 3 and 9-year old alleycrops under no-till cultivation. The 18-year old site consisted of treatments with mulch-only and mulch plus chicken manure under disk plow cultivation. Litterbags, filled with E. poeppigiana leaves from 3, 9 and 18-year old trees, were placed on the soil surface and collected over a period of 84 days. Results showed no significant differences in the amount of plant residues remaining after 84 days in the 3-, 9-, and 18-year-old systems, or between the manure and mulch-only treatments. Comparing mulch-only treatments, leaves in the 18-year old system decomposed most rapidly which may be due to disk-plow cultivation practices where litterbags were in direct contact with the soil as opposed to the no-till system in the younger alleycrops. [ABSTRACT FROM AUTHOR]
AB - Copyright of Agroforestry Systems is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Horticulture
KW - Agroforestry
KW - Agricultural systems
KW - Forests & forestry
N1 - Accession Number: 21962763; Oelbermann M. 1,2,3,4; Voroney R.P. 1,2,3,4; Schlönvoigt A.M. 1,2,3,4; Kass D.C.L. 1,2,3,4; Affiliations: 1: Department of Earth Sciences, University of Waterloo, Waterloo, ON N2L 3G1 ((phone: (519) 888-4567 Ext. 6495; fax: (519) 746-7484; e-mail: moelberm@sciborg.uwaterloo.ca )); 2: Department of Land Resource Science, University of Guelph, Guelph, ON N1G 2W1 Canada; 3: Area de Cuencas y Sistemas Agroforestales, CATIE Apdo 7170, Turrialba, Costa Rica; Current address: GFA Terra Systems, Latin America Division, Eulenkrugstrasse 82, 22359 Hamburg, Germany; 4: Area de Cuencas y Sistemas Agroforestales, CATIE Apdo 7170, Turrialba, Costa Rica; Current address: Northeast Regional Laboratory, Food and Drug Administration, Department of Health and Human Services, 158-15 Liberty Avenue, Jamaica, NY 11433, dclk9@hotmail.com; Issue Info: Dec2004, Vol. 63 Issue 1, p27; Thesaurus Term: Horticulture; Thesaurus Term: Agroforestry; Thesaurus Term: Agricultural systems; Thesaurus Term: Forests & forestry; NAICS/Industry Codes: 561730 Landscaping Services; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106597612
T1 - Putting prevention into practice. Screening for suicide risk.
AU - Guirguis-Blake J
AU - Hales CM
Y1 - 2004/12//12/1/2004
N1 - Accession Number: 106597612. Language: English. Entry Date: 20050325. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Suicide -- Diagnosis
KW - Suicide -- Risk Factors
KW - Adolescence
KW - Diagnosis, Psychosocial
KW - Education, Continuing (Credit)
KW - Male
SP - 2193
EP - B
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 70
IS - 11
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Program Director, U.S. Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 15606067.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mehendale, Sangeeta R.
AU - Aung, Han H.
AU - Jun-Jie Yin
AU - Lin, Elaine
AU - Fishbein, Anna
AU - Chong-Zhi Wang
AU - Jing-Tian Xie
AU - Chun-Su Yuan
T1 - Effects of Antioxidant Herbs on Chemotherapy-Induced Nausea and Vomiting in a Rat-Pica Model.
JO - American Journal of Chinese Medicine
JF - American Journal of Chinese Medicine
Y1 - 2004/12//
VL - 32
IS - 6
M3 - Article
SP - 897
EP - 905
PB - World Scientific Publishing Company
SN - 0192415X
AB - Nausea and vomiting are significant adverse effects of chemotherapeutic agents like cisplatin, and cause significant patient morbidity. Cisplatin treatment results in oxidant gut injury, which is postulated to be the primary cause of nausea and vomiting. We evaluated the effects of two antioxidant herbs, Scutellaria baicalensis and American ginseng berry, on cisplatin-induced nausea and vomiting using a rat model. Rats react to emetic or nausea-producing stimuli, such as cisplatin, with altered feeding habits, manifested by increased kaolin consumption (pica). We measured pica in rats to quantify cisplatin-induced nausea. We observed that pretreatment of rats with S. baicalensis or ginseng berry extracts resulted in a significant reduction in cisplatin-induced pica. The in vitro free radical scavenging ability of the herbal extract observed in the study, further confirmed the antioxidant action of the herb. We conclude that herbal antioxidants may have a role in attenuating cisplatin-induced nausea and vomiting. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG therapy
KW - CISPLATIN
KW - METAL-ammonia compounds
KW - ANTIOXIDANTS
KW - CHEMICAL inhibitors
KW - American Ginseng
KW - Antioxidant
KW - Chemotherapy
KW - Cisplatin
KW - Emesis
KW - Free Radical
KW - Ginseng Berry
KW - Kaolin
KW - Nausea and Vomiting
KW - Pica
KW - Rat
KW - Scutellaria baicalensis
N1 - Accession Number: 15276457; Mehendale, Sangeeta R. 1 Aung, Han H. 1 Jun-Jie Yin 2 Lin, Elaine 1 Fishbein, Anna 1 Chong-Zhi Wang 1 Jing-Tian Xie 1 Chun-Su Yuan 1; Email Address: cyuan@airway.uchicago.edu; Affiliation: 1: Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, USA 2: Center for Food Safety and Applied Nutritions, Food and Drug Administration (FDA), College Park, MD, USA; Source Info: 2004, Vol. 32 Issue 6, p897; Subject Term: DRUG therapy; Subject Term: CISPLATIN; Subject Term: METAL-ammonia compounds; Subject Term: ANTIOXIDANTS; Subject Term: CHEMICAL inhibitors; Author-Supplied Keyword: American Ginseng; Author-Supplied Keyword: Antioxidant; Author-Supplied Keyword: Chemotherapy; Author-Supplied Keyword: Cisplatin; Author-Supplied Keyword: Emesis; Author-Supplied Keyword: Free Radical; Author-Supplied Keyword: Ginseng Berry; Author-Supplied Keyword: Kaolin; Author-Supplied Keyword: Nausea and Vomiting; Author-Supplied Keyword: Pica; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Scutellaria baicalensis; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raiten, Daniel J.
AU - Picciano, Mary Frances
T1 - Vitamin D and health in the 21st century: bone and beyond. Executive summary.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2004/12//
VL - 80
IS - 6
M3 - Article
SP - 1673S
EP - 1677S
SN - 00029165
AB - Vitamin D is unique, in terms of its metabolism and physiologic features and the human reliance on both endogenous production (activation through exposure to ultraviolet light) and exogenous sources (diet, primarily fortified foods) to meet biological requirements. Recent evidence has indicated a reemergence of vitamin D-deficient rickets and an alarming prevalence of vitamin D insufficiency (ie, low circulating concentrations of 25-hydroxyvitamin D) in particular segments of the US population. Furthermore, evidence has emerged implicating vitamin D status in a range of adverse health conditions, including cancer and certain autoimmune diseases. Therefore, a conference organized by the National Institute of Child Health and Human Development and the National Institutes of Health Office of Dietary Supplements was held to explore current knowledge and to develop a research agenda to address the range of issues associated with vitamin D and health during the life cycle. These proceedings contain presentations about 1) existing data on vitamin D status in the United States and internationally, 2) the current state of knowledge regarding the biological functions of vitamin D, 3) the strength of evidence supporting reconsideration of current policies regarding vitamin D intake, 4) gaps in understanding of the factors affecting and current options for improving vitamin D status in the United States and internationally, and 5) research needs to address gaps in knowledge regarding vitamin D assessment, biological features, and requirements. This executive summary provides an overview of the conference and its conclusions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - National Institutes of Health conference
KW - Vitamin D
N1 - Accession Number: 94702838; Raiten, Daniel J. 1; Email Address: raitend@mail.nih.gov; Picciano, Mary Frances 2; Affiliations: 1: Office of Prevention Research and International Programs, Endocrinology, Nutrition, and Growth Branch, Center for Research on Mothers and Children, National Institute of Child Health and Human Development; 2: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD.; Issue Info: Dec2004, Vol. 80 Issue 6, p1673S; Author-Supplied Keyword: National Institutes of Health conference; Author-Supplied Keyword: Vitamin D; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Calvo, Mona S.
AU - Whiting, Susan J.
AU - Barton, Curtis N.
T1 - Vitamin D fortification in the United States and Canada: current status and data needs.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2004/12//
VL - 80
IS - 6
M3 - Article
SP - 1710S
EP - 1716S
SN - 00029165
AB - Most circulating 25-hydroxyvitamin D originates from exposure to sunlight; nevertheless, many factors can impair this process, necessitating periodic reliance on dietary sources to maintain adequate serum concentrations. The US and Canadian populations are largely dependent on fortified foods and dietary supplements to meet these needs, because foods naturally rich in vitamin D are limited. Fluid milk and breakfast cereals are the predominant vehicles for vitamin D in the United States, whereas Canada fortifies fluid milk and margarine. Reports of a high prevalence of hypovitaminosis D and its association with increased risks of chronic diseases have raised concerns regarding the adequacy of current intake levels and the safest and most effective way to increase vitamin D intake in the general population and in vulnerable groups. The usual daily intakes of vitamin D from food alone and from food and supplements combined, as estimated from the US third National Health and Nutrition Examination Survey, 1988-1994, show median values above the adequate intake of 5 μg/d for children 6-11 y of age; however, median intakes are generally below the adequate intake for female subjects > 12 y of age and men > 50 y. In Canada, there are no national survey data for estimation of intake. Cross-sectional studies suggest that current US/Canadian fortification practices are not effective in preventing hypovitaminosis D, particularly among vulnerable populations during the winter, whereas supplement use shows more promise. Recent prospective intervention studies with higher vitamin D concentrations provided evidence of safety and efficacy for fortification of specific foods and use of supplements. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - dietary requirements
KW - dietary supplements
KW - food fortification
KW - nutrition labeling
KW - Usual vitamin D intake
KW - vitamin D insufficiency
N1 - Accession Number: 94702809; Calvo, Mona S. 1; Email Address: mona.calvo@cfsan.fda.gov.; Whiting, Susan J. 2; Barton, Curtis N. 3; Affiliations: 1: Office of Applied Research and Safety Assessment and Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD; 2: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatchewan, Canada; 3: Office of Mathematical Assessment and Services, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD; Issue Info: Dec2004, Vol. 80 Issue 6, p1710S; Author-Supplied Keyword: dietary requirements; Author-Supplied Keyword: dietary supplements; Author-Supplied Keyword: food fortification; Author-Supplied Keyword: nutrition labeling; Author-Supplied Keyword: Usual vitamin D intake; Author-Supplied Keyword: vitamin D insufficiency; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106620530
T1 - Vitamin D fortification in the United States and Canada: current status and data needs...Vitamin D and Health in the 21st Century: proceedings of a conference held in Bethesda, MD, October 9-10, 2003
AU - Calvo MS
AU - Whiting SJ
AU - Barton CN
Y1 - 2004/12//
N1 - Accession Number: 106620530. Language: English. Entry Date: 20050429. Revision Date: 20150819. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Food, Fortified
KW - Public Health -- Canada
KW - Public Health -- United States
KW - Vitamin D
KW - Adolescence
KW - Adult
KW - Canada
KW - Cereals
KW - Child
KW - Dairy Products
KW - Diet
KW - Dietary Supplementation
KW - Female
KW - Health Policy
KW - Male
KW - Margarine
KW - Milk
KW - Nutrition Policy
KW - Nutritional Assessment
KW - Nutritional Status
KW - Reference Values
KW - Sunlight
KW - United States
KW - Vitamin D Deficiency -- Prevention and Control
KW - Vitamin D -- Metabolism
KW - Vitamin D -- Pharmacokinetics
SP - 1710S
EP - 6S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 80
IS - 6
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - Most circulating 25-hydroxyvitamin D originates from exposure to sunlight; nevertheless, many factors can impair this process, necessitating periodic reliance on dietary sources to maintain adequate serum concentrations. The US and Canadian populations are largely dependent on fortified foods and dietary supplements to meet these needs, because foods naturally rich in vitamin D are limited. Fluid milk and breakfast cereals are the predominant vehicles for vitamin D in the United States, whereas Canada fortifies fluid milk and margarine. Reports of a high prevalence of hypovitaminosis D and its association with increased risks of chronic diseases have raised concerns regarding the adequacy of current intake levels and the safest and most effective way to increase vitamin D intake in the general population and in vulnerable groups. The usual daily intakes of vitamin D from food alone and from food and supplements combined, as estimated from the US third National Health and Nutrition Examination Survey, 1988-1994, show median values above the adequate intake of 5 microg/d for children 6-11 y of age; however, median intakes are generally below the adequate intake for female subjects > 12 y of age and men > 50 y. In Canada, there are no national survey data for estimation of intake. Cross-sectional studies suggest that current US/Canadian fortification practices are not effective in preventing hypovitaminosis D, particularly among vulnerable populations during the winter, whereas supplement use shows more promise. Recent prospective intervention studies with higher vitamin D concentrations provided evidence of safety and efficacy for fortification of specific foods and use of supplements. Copyright © 2004 American Society for Clinical Nutrition
SN - 0002-9165
AD - Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD
U2 - PMID: 15585792.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Coben, Jeffrey H.
AU - Steiner, Claudia A.
AU - Owens, Pamela
T1 - Motorcycle-related hospitalizations in the United States, 2001
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2004/12//
VL - 27
IS - 5
M3 - Article
SP - 355
EP - 362
SN - 07493797
AB - Objectives: To estimate the prevalence of motorcycle-related hospitalization in the United States in 2001 and to describe the demographic, clinical, hospital, and financial characteristics associated with these injuries. Methods: Cross-sectional analysis of the 2001 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project was conducted in 2003. Results: There were an estimated 30,505 (confidence interval=26,566–34,445) motorcycle-related hospital discharges in 2001. Approximately 62% of cases were aged ≥30 years, and males accounted for 89% of cases. The most common principal diagnoses were fractures of the lower limb (29.4%), fractures of the upper limb (13.1%), and intracranial injuries (12.3%). The mean length of stay was 5 days, the median hospital charge was $15,404, and the total estimated hospital charges were >$841 million. The majority of patients (56.5%) were admitted to large urban teaching hospitals, and these hospitals accounted for nearly 70% of all hospital charges. Approximately 26% of cases were self-pay or listed public insurance as the expected payer. Conclusions: These findings shed light on the substantial morbidity and financial impact of motorcycle-related injuries. Renewed and strengthened prevention efforts are warranted. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MOTORCYCLES
KW - HOSPITAL care
KW - UNITED States
N1 - Accession Number: 15450197; Coben, Jeffrey H. 1,2; Email Address: jcoben@hsc.wva.edu Steiner, Claudia A. 1 Owens, Pamela 1; Affiliation: 1: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services (Coben, Steiner, Owens), Washington DC 2: Departments of Emergency Medicine and Community Medicine, Injury Control Research Center, West Virginia University (Coben), Morgantown, West Virginia; Source Info: Dec2004, Vol. 27 Issue 5, p355; Subject Term: MEDICAL care costs; Subject Term: MOTORCYCLES; Subject Term: HOSPITAL care; Subject Term: UNITED States; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 441228 Motorcycle, ATV, and All Other Motor Vehicle Dealers; NAICS/Industry Codes: 441220 Motorcycle, boat and other motor vehicle dealers; NAICS/Industry Codes: 415190 Recreational and other motor vehicles merchant wholesalers; NAICS/Industry Codes: 336991 Motorcycle, Bicycle, and Parts Manufacturing; NAICS/Industry Codes: 336990 Other transportation equipment manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.amepre.2004.08.002
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Healthy People Curriculum Task Force: A commentary by the Surgeon General
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2004/12//
VL - 27
IS - 5
M3 - Editorial
SP - 478
EP - 479
SN - 07493797
N1 - Accession Number: 15450212; Carmona, Richard H. 1; Affiliation: 1: Office of the Surgeon General, U.S. Public Health Service Commissioned Corps, U.S. Department of Health and Human Services, Rockville, Maryland; Source Info: Dec2004, Vol. 27 Issue 5, p478; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.amepre.2004.09.004
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ER -
TY - JOUR
AU - Richardson, Douglas D.
AU - Kannamkumarath, Sasi S.
AU - Wuilloud, Rodolfo G.
AU - Caruso, Joseph A.
T1 - Hydride Generation Interface for Speciation Analysis Coupling Capillary Electrophoresis to Inductively Coupled Plasma Mass Spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2004/12//12/1/2004
VL - 76
IS - 23
M3 - Article
SP - 7137
EP - 7142
SN - 00032700
AB - A novel hydride generation (HG) interface for coupling capillary electrophoresis (CE) with inductively coupled plasma mass spectrometry (ICPMS) is presented in this work. The CE-HG-ICPMS interface was applied to the separation and quantitation of common arsenic species. Lack of a commercially available HG interface for CE- ICPMS led to a three concentric tube design allowing alleviation of back pressure commonly observed in CE- HG-ICPMS. Due to the high sensitivity and element- specific detection of ICPMS, quantitative analysis of As(III), As(V), monomethylarsonic acid, and dimethylarsinic acid was achieved. Optimization of CE separation conditions resulted in the use of 20 mmol L-1 sodium borate with 2% osmotic flow modifier (pH 9.0) and -20 kV applied potential for baseline resolution of each arsenic species in the shortest time. Hydride generation conditions were optimized through multiple electrophoretic separation analyses with 5% HCI and 3% NaBH4 (in 0.2% NaOH) determined to be the optimum conditions. After completion of system optimization, detection limits obtained for the arsenic species were less than 40 ng in with electromigration time precision less than 1% within a total analysis lime of 9.0 mm. Finally, the interface was used for speciation analysis of arsenic in river and tap water samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTROPHORESIS
KW - INDUCTIVELY coupled plasma mass spectrometry
KW - ARSENIC
KW - ELECTRODIFFUSION
KW - HYDRIDES
KW - CACODYLIC acid
N1 - Accession Number: 15320341; Richardson, Douglas D. 1 Kannamkumarath, Sasi S. 1 Wuilloud, Rodolfo G. 1,2 Caruso, Joseph A. 1; Email Address: joseph.caruso@uc.edu.; Affiliation: 1: Department of Chemistry, University of Cincinnati Cincinnati, Ohio 45221-0172, 2: Forensic Chemistry Center, U.S. Food and Drug Administration, 6751 Steger Drive, Cincinnati, Ohio 45237; Source Info: 12/1/2004, Vol. 76 Issue 23, p7137; Subject Term: ELECTROPHORESIS; Subject Term: INDUCTIVELY coupled plasma mass spectrometry; Subject Term: ARSENIC; Subject Term: ELECTRODIFFUSION; Subject Term: HYDRIDES; Subject Term: CACODYLIC acid; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106645186
T1 - An evaluation of portable high-efficiency particulate air filtration for expedient patient isolation in epidemic and emergency response.
AU - Mead K
AU - Johnson DL
Y1 - 2004/12//2004 Dec
N1 - Accession Number: 106645186. Language: English. Entry Date: 20050610. Revision Date: 20150818. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646.
KW - Patient Isolation -- Equipment and Supplies
KW - Ventilation -- Equipment and Supplies
KW - Filtration
KW - Respiratory Protective Devices
KW - Ventilation
KW - Evaluation Research
KW - Human
SP - 635
EP - 645
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
JA - ANN EMERG MED
VL - 44
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - Extraordinary incidents resulting in airborne infectious disease outbreaks could produce patient isolation requirements that exceed most hospitals' capacity. This article investigates expedient methods to establish airborne infection isolation areas using a commercially available portable filtration unit and common hardware supplies. The study was conducted within a conventional, nonisolation hospital room, and researchers evaluated several airborne isolation configurations that did not require building ventilation or structural modifications. A portable high-efficiency particulate air filtration unit and full-length plastic curtains established a 'zone-within-zone' protective environment using local capture and directional airflows. The cost of constructing the expedient configurations was less than US2,300 dollars and required fewer than 3 person-hours to construct. A medical nebulizer aerosolized polystyrene latex microspheres to generate respirable condensation nuclei. Aerosol spectrometers sized and counted respirable particles at the source patient and health care worker positions and in areas outside the inner zone. The best-performing designs showed no measurable source migration out of the inner isolation zone and mean respirable particle counts up to 87% lower at the health care worker position(s) than those observed directly near the source patient location. Investigators conclude that with careful implementation under emergency circumstances in which engineered isolation rooms are unavailable, expedient methods can provide affordable and effective patient isolation while reducing exposure risks and potential disease transmission to health care workers, other patients, and visitors.
SN - 0196-0644
AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway (MS R5), Cincinnati, OH 45226; kmead@cdc.gov
U2 - PMID: 15573040.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Elkins, Christopher A.
AU - Mullis, Lisa B.
T1 - Bile-Mediated Aminoglycoside Sensitivity in Lactobacillus Species Likely Results from Increased Membrane Permeability Attributable to Cholic Acid.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2004/12//
VL - 70
IS - 12
M3 - Article
SP - 7200
EP - 7209
SN - 00992240
AB - Few studies have been conducted on antimicrobial resistance in lactobacilli, presumably because of their nonpathogenic nature as anaerobic commensals. We assessed resistance in 43 type strains and isolates representing 14 species by using agar disk diffusion and MIC analysis in MRS medium. Most noteworthy were two general phenotypes displayed by nearly every strain tested: (i) they were more susceptible (up to 256-fold in some cases) to the deconjugated bile acid cholic acid than to the conjugate taurocholic or taurodeoxycholic acid, and (ii) they became susceptible to aminoglycosides when assayed on agar medium containing 0.5% fractionated bovine bile (ox gall). Two-dimensional MIC analyses of one representative strain, Lactobacillus plantarum WCFS1, at increasing concentrations of ox gall (0 to 30.3 mg/ml) displayed corresponding decreases in resistance to all of the aminoglycosides tested and ethidium bromide. This effect was clinically relevant, with the gentamicin MIC decreasing from >1,000 to 4 µg/ml in just 3.8 mg of ox gall per mi. In uptake studies at pH 6.5, [G-³H]gentamicin accumulation increased over control levels when cells of this strain were exposed to bile acids or reserpine but not when they were exposed to carbonyl cyanide m-chlorophenylhydrazone. The effect was dramatic, particularly with cholic acid, increasing up to 18-fold, whereas only modest increases, 3and 5-fold, could be achieved with taurocholic acid and ox gall, respectively. Since L. plantarum, particularly strain WCFS1, is known to encode bile salt hydrolase (deconjugation) activity, our data indicate that mainly cholic acid, but not taurocholic acid, effectively permeabilizes the membrane to aminoglycosides. However, at phs approaching neutral conditions in the intestinal lumen, aminoglycoside resistance due to membrane impermeability may be complemented by a potential efflux mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINOGLYCOSIDES
KW - AMINO compounds
KW - GLYCOSIDES
KW - LACTOBACILLUS
KW - CHOLIC acid
KW - BILE acids
N1 - Accession Number: 15749309; Elkins, Christopher A. 1; Email Address: chris.elkins@fda.hhs.gov Mullis, Lisa B. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas; Source Info: Dec2004, Vol. 70 Issue 12, p7200; Subject Term: AMINOGLYCOSIDES; Subject Term: AMINO compounds; Subject Term: GLYCOSIDES; Subject Term: LACTOBACILLUS; Subject Term: CHOLIC acid; Subject Term: BILE acids; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1 128/AEM.70.12.7200-7209.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ruder, Avima M.
AU - Waters, Martha A.
AU - Butler, Mary Ann
AU - Carreón, Tania
AU - Calvert, Geoffrey M.
AU - Davis-King, Karen E.
AU - Schulte, Paul A.
AU - Sanderson, Wayne T.
AU - Ward, Elizabeth M.
AU - Connally, L. Barbara
AU - Heineman, Ellen F.
AU - Mandel, Jack S.
AU - Morton, Roscoe F.
AU - Reding, Dougias J.
AU - Rosenman, Kenneth D.
AU - Talaska, Glenn
T1 - Gliomas and Farm Pesticide Exposure in Men: The Upper Midwest Health Study.
JO - Archives of Environmental Health
JF - Archives of Environmental Health
Y1 - 2004/12//
VL - 59
IS - 12
M3 - Article
SP - 650
EP - 658
PB - Taylor & Francis Ltd
SN - 00039896
AB - The article presents a study on farm pesticide exposure and glioma risk in men. The study involved adult men who were nonmetropolitan residents of Michigan, Wisconsin, Minnesota, and Iowa. Multiple logistic regressions, which were used to control for farm residence, education, age, age group, and exposure to other pesticides, revealed no association between glioma and 12 specific pesticides. Farm pesticide exposure was found to have no positive association with glioma. The excess brain cancer risk may be caused by other farm exposures.
KW - Pesticides
KW - Agricultural chemicals
KW - Health
KW - Gliomas
KW - Age groups
KW - Michigan
KW - Wisconsin
KW - Minnesota
KW - Iowa
KW - agricultural workers' diseases
KW - case-control studies
KW - glioma
KW - pesticides
KW - rural population
N1 - Accession Number: 21832668; Ruder, Avima M. 1; Email Address: amr2@cdc.gov; Waters, Martha A. 1; Butler, Mary Ann 1; Carreón, Tania 1; Calvert, Geoffrey M. 1; Davis-King, Karen E. 1; Schulte, Paul A. 1; Sanderson, Wayne T. 1; Ward, Elizabeth M. 1; Connally, L. Barbara 1; Heineman, Ellen F. 2; Mandel, Jack S. 3; Morton, Roscoe F. 4; Reding, Dougias J. 5; Rosenman, Kenneth D. 6; Talaska, Glenn 7; Affiliations: 1: The National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Cincinnati, Ohio; 2: The National Cancer Institute Rockville, Maryland; 3: The University of Minnesota Minneapolis, Minnesota; 4: The Mercy Foundation Des Moines, Iowa; 5: The Marshfield Clinic Marshfield, Wisconsin; 6: Michigan State University East Lansing, Michigan; 7: The University of Cincinnati Cincinnati, Ohio; Issue Info: Dec2004, Vol. 59 Issue 12, p650; Thesaurus Term: Pesticides; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Health; Subject Term: Gliomas; Subject Term: Age groups; Subject: Michigan; Subject: Wisconsin; Subject: Minnesota; Subject: Iowa; Author-Supplied Keyword: agricultural workers' diseases; Author-Supplied Keyword: case-control studies; Author-Supplied Keyword: glioma; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: rural population; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Powers, John H.
AU - Wingard, John R.
T1 - Empirical Antifungal Therapy in Febrile Neutropenic Patients: Caution about Composite End Points and the Perils of P Values.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2004/12//12/1/2004
VL - 39
IS - 11
M3 - Letter
SP - 1738
EP - 1739
SN - 10584838
AB - Presents letters to the editor. Debate on clinical trials of empirical antifungal therapy in febrile neutropenic patients; Insight into the issue of invasive fungal infection.
KW - Antifungal agents
KW - Anti-infective agents
KW - Letters to the editor
KW - Febrile neutropenia
KW - Debates & debating
KW - Clinical trials
KW - Therapeutics
N1 - Accession Number: 15055576; Powers, John H. 1; Email Address: powersoh@cder.fda.gov; Wingard, John R. 2; Email Address: wingajr@medicine.ufl.edu; Affiliations: 1: US Food and Drug Administration, Rockville, Maryland.; 2: Division of Hematology/Oncology, Department of Medicine, Blood and Marrow Transplant Program, University of Florida Shands Cancer Center, Gainesville, Florida.; Issue Info: 12/1/2004, Vol. 39 Issue 11, p1738; Thesaurus Term: Antifungal agents; Thesaurus Term: Anti-infective agents; Subject Term: Letters to the editor; Subject Term: Febrile neutropenia; Subject Term: Debates & debating; Subject Term: Clinical trials; Subject Term: Therapeutics; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Willke, Richard J.
AU - Burke, Laurie B.
AU - Erickson, Pennifer
T1 - Measuring treatment impact: a review of patient-reported outcomes and other efficacy endpoints in approved product labels
JO - Controlled Clinical Trials
JF - Controlled Clinical Trials
Y1 - 2004/12//
VL - 25
IS - 6
M3 - Article
SP - 535
EP - 552
SN - 01972456
AB - Abstract: Context: The term “patient-reported outcomes” (PROs) has evolved to include any endpoint derived from patient reports, whether collected in the clinic, in a diary, or by other means, including single-item outcome measures, event logs, symptom reports, formal instruments to measure health-related quality of life (HRQL), health status, adherence, and satisfaction with treatment. This term coincides with the explicit interest from drug development researchers and regulatory authorities in the appropriate utilization and reporting of treatment impact measures. Objective: To determine the level and nature of use of PROs compared to other types of effectiveness endpoints in approved product labeling for new drugs recently approved in the United States. Design and sources: Review and analysis of effectiveness endpoints as reported in clinical study descriptions in approved product labeling of new molecular entities (NMEs) approved in the United States from 1997 through 2002. Main outcome measures: Effectiveness study endpoints reported in approved product labeling that fall into the following categories of measurement: PROs, clinician-reported outcomes (CROs), and laboratory test/device measurement endpoints. Results: PROs were reported in 64 (30%) of the 215 product labels reviewed. Clinician-reported outcomes were reported most frequently (62%) followed by laboratory/device endpoints (50%). PROs were the only type of endpoint used in the FDA-approved label for 23 products. Formal multiitem PRO scales were cited 22 times. Use of PROs is most common in antiinflammatory, CNS, gastrointestinal, respiratory, allergic conjunctivitis, and urologic therapy areas. The frequency of reported PRO use over this period did not change. Conclusion: PROs, although quite variable as a class of study endpoints, were found to have a significant role in the development and evaluation of new medicines. More formal guidance from the FDA about use of such measures along with continued collaboration by PRO researchers to develop and disseminate standards will enhance the appropriate use of PROs in future drug development and labeling. [Copyright &y& Elsevier]
AB - Copyright of Controlled Clinical Trials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTCOME assessment (Medical care)
KW - MEDICAL personnel
KW - DRUG development
KW - EYE -- Inflammation
KW - Drug development
KW - Drug labeling
KW - Health-related quality of life
KW - Patient-reported outcomes
N1 - Accession Number: 17122389; Willke, Richard J. 1; Email Address: richard.j.willke@pfizer.com Burke, Laurie B. 2 Erickson, Pennifer 3; Affiliation: 1: Pfizer Inc., Bridgewater, NJ, United States 2: U.S. Food and Drug Administration, Rockville, MD, United States 3: Hershey Medical School, Pennsylvania State University, Hershey, PA, United States; Source Info: Dec2004, Vol. 25 Issue 6, p535; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL personnel; Subject Term: DRUG development; Subject Term: EYE -- Inflammation; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: Drug labeling; Author-Supplied Keyword: Health-related quality of life; Author-Supplied Keyword: Patient-reported outcomes; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.cct.2004.09.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rao, K. Murali Krishna
AU - Porter, Dale W.
AU - Meighan, Terence
AU - Castranova, Vince
T1 - The Sources of Inflammatory Mediators in the Lung after Silica Exposure.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2004/12//
VL - 112
IS - 17
M3 - Article
SP - 1679
EP - 1685
PB - Superintendent of Documents
SN - 00916765
AB - The expression of 10 genes implicated in regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in viva. Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. AMs isolated after intratracheal instillation of silica up-regulated mRNA levels of four additional genes [granulocyte/macrophage-colony stimulating factor (GM-CSF), IL-1β, IL-10, and inducible nitric oxide synthase]. IL-6, MCP-1, and MIP-2 protein levels were elevated in bronchoalveolar lavage fluid. Fibroblasts under basal culture conditions express much higher levels of IL-6 and GM-CSF compared with AMs. Coculture of AMs and alveolar type II cells, or coculture of AMs and lung fibroblasts, in contact cultures or Transwell chambers, revealed no synergistic effect. Therefore, such interaction does not explain the effects seen in viva. Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental impact analysis
KW - Inflammation -- Mediators
KW - Silica -- Environmental aspects
KW - Alveolar process
KW - Macrophages
KW - Genetic disorders
KW - alveolar macrophages
KW - alveolar type II cells
KW - cytokines
KW - fibroblasts
KW - gene expression
KW - lung
KW - silica.
N1 - Accession Number: 15548995; Rao, K. Murali Krishna 1; Email Address: mir8@cdc.gov; Porter, Dale W. 1; Meighan, Terence 1; Castranova, Vince 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Dec2004, Vol. 112 Issue 17, p1679; Thesaurus Term: Environmental impact analysis; Subject Term: Inflammation -- Mediators; Subject Term: Silica -- Environmental aspects; Subject Term: Alveolar process; Subject Term: Macrophages; Subject Term: Genetic disorders; Author-Supplied Keyword: alveolar macrophages; Author-Supplied Keyword: alveolar type II cells; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: fibroblasts; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: lung; Author-Supplied Keyword: silica.; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106454385
T1 - Guideline for prevention of surgical site infection, 1999.
AU - Mangram AJ
AU - Horan TC
AU - Pearson ML
AU - Silver LC
AU - Jarvis WR
Y1 - 2004/12//2004 Dec
N1 - Accession Number: 106454385. Corporate Author: Hospital Infection Control Practices Advisory Committee. Language: English. Entry Date: 20060609. Revision Date: 20150818. Publication Type: Journal Article; practice guidelines; tables/charts. Journal Subset: Nursing; USA.
KW - Infection Control -- Methods
KW - Infection Control -- Standards
KW - Perioperative Care -- Standards
KW - Surgical Wound Infection
KW - Surgical Wound Infection -- Prevention and Control
KW - Disease Surveillance
KW - Inpatients
KW - Staphylococcal Infections -- Prevention and Control
KW - Surgical Patients
SP - 247
EP - 278
JO - Excellence in Nursing Knowledge
JF - Excellence in Nursing Knowledge
JA - EXCELLENCE NURS KNOWLEDGE
CY - Indianapolis, Indiana
PB - Sigma Theta Tau International
SN - 1554-5989
AD - Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Martinez, Kenneth
AU - Rao, Carol
AU - Burton, Nancy
T1 - Exposure assessment and analysis for biological agents.
JO - Grana
JF - Grana
Y1 - 2004/12//
VL - 43
IS - 4
M3 - Article
SP - 193
EP - 208
PB - Taylor & Francis Ltd
SN - 00173134
AB - Airborne biological agents have become prominent safety and health issues in agriculture, biotechnology, industrial settings, and the indoor environment. Each of these environments presents unique exposure concerns due to the nature of the encountered biological agent, the microbial concentrations, the modes of exposure, and the susceptibility of the exposed population. Acceptable levels of airborne microorganisms have not been established and the sampling methods and analytical techniques employed to assess airborne biocontaminants are varied and non-standardized. This paper reviews and compares the different air sampling methods for biological agents and classical analytical methods (i.e., culture and microscopy), analysis for specific microorganism constituents (i.e., ergosterol, muramic acid, glucans, allergens, mycotoxins, endotoxins) and molecular methods (i.e., polymerase chain reactions). Each of the described methods has distinct advantages and disadvantages. Selection of sampling and analytical methods depends upon the nature of the information that is sought; there is no one ideal sampling or analytical method. Combinations of sampling and analytical methods can provide a wide range of data that can be effectively tailored to many different environmental settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Grana is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROORGANISMS
KW - MICROBIOLOGY
KW - ENDOTOXINS
KW - BACTERIAL toxins
KW - POLYMERASE chain reaction
KW - HIGH technology
N1 - Accession Number: 15328370; Martinez, Kenneth 1 Rao, Carol 2 Burton, Nancy 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R11, Cincinnati, 45213 Oh 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale, MS 2800, USA; Source Info: 2004, Vol. 43 Issue 4, p193; Subject Term: MICROORGANISMS; Subject Term: MICROBIOLOGY; Subject Term: ENDOTOXINS; Subject Term: BACTERIAL toxins; Subject Term: POLYMERASE chain reaction; Subject Term: HIGH technology; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106636496
T1 - Health promotion in small workplaces -- a feasibility study.
AU - Fine A
AU - Ward M
AU - Burr M
AU - Tudor-Smith C
AU - Kingdon A
Y1 - 2004/12//
N1 - Accession Number: 106636496. Language: English. Entry Date: 20050527. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; UK & Ireland. Grant Information: Bro Taf Health Authority. NLM UID: 0374646.
KW - Back Pain -- Prevention and Control
KW - Coronary Disease -- Prevention and Control
KW - Health Behavior
KW - Health Promotion
KW - Occupational Health
KW - Back Pain -- Risk Factors
KW - Cardiovascular Risk Factors
KW - Chi Square Test
KW - Comparative Studies
KW - Female
KW - Funding Source
KW - Health Education
KW - Male
KW - P-Value
KW - Pilot Studies
KW - Private Sector
KW - Public Sector
KW - Questionnaires
KW - Random Assignment
KW - Risk Assessment
KW - Self Report
KW - Stress Management
KW - Stress, Occupational
KW - Support, Psychosocial
KW - T-Tests
KW - Wales
KW - Work Environment
KW - Human
SP - 334
EP - 346
JO - Health Education Journal
JF - Health Education Journal
JA - HEALTH EDUC J
VL - 63
IS - 4
PB - Sage Publications, Ltd.
AB - Objective: To address the risk factors for coronary heart disease (CHD) and back pain in workplaces employing less than 50 people in the Merthyr/Cynon area of South Wales.Design: A comparative study of small workplaces randomly allocated into either CHD or musculo-skeletal intervention groups.Setting: Small workplaces, employing 50 staff or less.Method: Following random allocation into CHD or musculo-skeletal groups, participating workplaces received a dual approach consisting of organisational health promotion policy advice and support with individual employee health screening, advice and limited intervention.Results: Stress was the most commonly reported CHD risk factor amongst respondents and was more prevalent amongst women, although there was also an important differentiation identified between 'workplace' and 'domestic' stress. Advice about stress was twice as often reported in the private than in the public sector, although the prevalence of'current stress' was slightly higher among the public than the private workers. Most smokers wanted to stop. Over 50 per cent of respondents reported some form of musculo-skeletal problem and physical inactivity was generally high across all sectors. There appeared to be an increased awareness of health messages following the interventions but no statistically significant changes in behaviour were evident. Nearly all workplaces (97 per cent) had smoking policies. The commonest obstacle to health promotion was lack of obvious benefit as perceived by the employer.Conclusions: Overall, there appeared to be a resistance to workplace health promotion, which was viewed as not benefiting the business, requiring too much time, and not the employer's responsibility. Most small businesses do not have the resources available to larger employers to address the health needs of their workforce and alternative ways of helping these workplaces needs to be explored. The major issue that needs to be addressed is stress, which may originate in the workplace or at home. Other important health related matters include exercise, diet, smoking and spinal pain.
SN - 0017-8969
AD - Workplace Counsellor, National Public Health Service for Wales, Merthyr Tydfil
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yung Sung Cheng
AU - Guilmette, Raymond A.
AU - Yue Zhou
AU - Jun Gao
AU - Thomas Labone
AU - Whicker, Jeffrey J.
AU - Hoover, Mark D.
T1 - CHARACTERIZATION OF PLUTONIUM AEROSOL COLLECTED DURING AN ACCIDENT.
JO - Health Physics
JF - Health Physics
Y1 - 2004/12//
VL - 87
IS - 6
M3 - Article
SP - 596
EP - 605
SN - 00179078
AB - This study determined the plutonium particle size distribution and dissolution rate of 238PuO2 aerosol collected during the 16 March 2000 release of an undetermined amount of 238PuO2 in a room within a plutonium facility at Los Alamos National Laboratory. The facility has been in operation since 1978 to support the development, fabrication, and testing of 238Pu heat sources for the U.S. Department of Energy. Several workers were in the room at the time of the release and in vivo study of five of the workers began the day after the exposure event. Four of the subjects subsequently received chelation therapy. Over 30 fixed air filter samplers (FASs) and four continuous air monitors (CAMs) were operating in the room during the radiological release. One 47-mm-diameter glass fiber FAS filter and one 25-cm-diameter mixed cellulose ester CAM filter containing Pu aerosol from the incident were examined in the study described here. Total alpha radioactivity on the filters was determined by gross alpha counting. Isotopic identification of the 238Pu was made by alpha spectrometry. Film autoradiography was used to characterize the spatial distribution of alpha-emitting particles on the filters. Track-etch autoradiography was used to estimate the distribution of alpha radioactivity in individual plutonium particles on the filters for particle size measurement. The glass fiber filter was then cut into six sections. Particles from two sections were resuspended in alcohol, dispersed as an aerosol using a Lovelace nebulizer, and characterized by aerodynamic diameter using a Lovelace Multi-jet cascade impactor. The measured activity median aerodynamic diameter from the cascade impactor was 4.8 µm with a geometric standard deviation of 1.5. That agreed with the size distribution obtained from the alpha track detection technique. The remaining four filter sections were used in an in vitro dissolution study with synthetic serum ultrafiltrate. The retention of undissolved was consistent with a biphasic exponential function. The majority of the 238Pu dissolved with a half-time of 900 d. The information on particle size distribution and solubility from this study was useful in assigning a radiation dose to the exposed workers, supporting the decision to administer chelation therapy, and providing a model for characterizing accident-associated aerosols in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Physics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Plutonium
KW - Aerosols (Sprays)
KW - Air pollution
KW - Air quality
KW - Radioactivity
KW - Transuranium elements
KW - accident analysis
KW - aerosols
KW - exposure
KW - occupational
KW - plutonium
N1 - Accession Number: 15284228; Yung Sung Cheng 1; Email Address: ycheng@lrri.org; Guilmette, Raymond A. 2; Yue Zhou 1; Jun Gao 1; Thomas Labone 3; Whicker, Jeffrey J. 2; Hoover, Mark D. 4; Affiliations: 1: Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM; 2: Los Alamos National Laboratory, P0 Box 1663, Los Alamos, NM; 3: Savannah River Site, Building 735-4B, Aiken, SC; 4: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV; Issue Info: Dec2004, Vol. 87 Issue 6, p596; Thesaurus Term: Plutonium; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Air pollution; Thesaurus Term: Air quality; Thesaurus Term: Radioactivity; Subject Term: Transuranium elements; Author-Supplied Keyword: accident analysis; Author-Supplied Keyword: aerosols; Author-Supplied Keyword: exposure; Author-Supplied Keyword: occupational; Author-Supplied Keyword: plutonium; Number of Pages: 10p; Illustrations: 2 Diagrams, 3 Charts, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shi, Leiyu
AU - Stevens, Gregory D.
AU - Wulu, John T., Jr.
AU - Politzer, Robert M.
AU - Xu, Jiahong
AD - Johns Hopkins U
AD - Center for Healthier Children, Families and Communities, UCLA
AD - US Department of Health and Human Services
AD - US Department of Health and Human Services
AD - Johns Hopkins U
T1 - America's Health Centers: Reducing Racial and Ethnic Disparities in Perinatal Care and Birth Outcomes
JO - Health Services Research
JF - Health Services Research
Y1 - 2004/12/01/
VL - 39
IS - 6
SP - 1881
EP - 1901
SN - 00179124
N1 - Accession Number: 0770193; Keywords: Health; Racial; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200504
N2 - To examine whether community health centers (CHCs) reduce racial/ethnic disparities in perinatal care and birth outcomes, and to identify CHC characteristics associated with better outcomes. Racial/ethnic disparities in certain prenatal services and birth outcomes may be lower in CHCs compared to the general population, despite serving higher-risk groups. Within CHCs, increasing first-trimester prenatal care use through perinatal care capacity may lead to further improvement in birth outcomes for the underserved.
KW - Analysis of Health Care Markets I11
KW - Health Production I12
KW - Economics of Minorities, Races, Indigenous Peoples, and Immigrants; Non-labor Discrimination J15
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Buchmueller, Thomas C.
AU - Gilmer, Todd
AU - Harris, Katherine
T1 - Health Plan Disenrollment in a Choice-Based Medicaid Managed Care Program.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2004///Winter2004/2005
VL - 41
IS - 4
M3 - Article
SP - 447
EP - 460
SN - 00469580
AB - Consumer decisions to switch health plans have implications for quality of care and risk selection. We examine factors related to time to disenrollment in a Medicaid managed care program where beneficiaries face a menu of plans and can change plans every month. Several findings have direct policy relevance. Families and individuals who make active choices upon entering the program are at substantially lower risk of disenrollment than those who are auto-assigned. Interactions between enrollee ethnicity and provider language proficiency suggest that enrollee satisfaction depends on the cultural competence of providers. Differential disenrollment by risk status results in adverse retention for certain types of plans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAID
KW - NATIONAL health insurance
KW - HEALTH planning
KW - MEDICAL policy
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 16785940; Buchmueller, Thomas C. 1; Email Address: tcbuchmu@uci.edu; Gilmer, Todd 2; Harris, Katherine 3; Affiliations: 1: Associate Professor, Graduate School of Management, University of California, Irvine; 2: Assistant Professor, Department of Family and Preventive Medicine, University of California, San Diego; 3: Service Fellow, Office of Applied Studies, Substance Abuse and Mental Health Services Administration; Issue Info: Winter2004/2005, Vol. 41 Issue 4, p447; Thesaurus Term: MEDICAID; Thesaurus Term: NATIONAL health insurance; Subject Term: HEALTH planning; Subject Term: MEDICAL policy; Subject Term: PUBLIC health -- United States; Subject: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 14p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Guor-Cheng Fang
AU - Yuh-Shen Wu
AU - Pi-Cheng Fu, Peter
AU - Cheng-Nan Chang
AU - Tse-Tsung Ho
AU - Ming-Hsiang Chen
T1 - The study of temple and pastureland particle-bound polycyclic aromatic hydrocarbons concentrations in central Taiwan.
JO - International Journal of Environment & Pollution
JF - International Journal of Environment & Pollution
Y1 - 2004/12//
VL - 22
IS - 6
M3 - Article
SP - 688
EP - 700
SN - 09574352
AB - The concentrations of polycyclic aromatic hydrocarbons in the atmosphere were measured simultaneously at Tzu Yun Yen temple and Tung Hai University pastureland in Taichung, central Taiwan. At both sites, 24 h samplings were performed between August 2001 and December 2001. The results indicated that high molecular mass polycyclic aromatic hydrocarbons are predominant at the Tzu Yun Yen temple sampling site. Moreover, the PM2.5 (fine particulate) fraction of total polycyclic aromatic hydrocarbons was higher than that of the PM2.5-10 (coarse particulate) fraction by a factor of about 1.48 at the temple sampling site. This ratio was 1.24 for the pastureland environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Environment & Pollution is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Polycyclic aromatic compounds
KW - Hydrocarbons
KW - Chemicals
KW - Taiwan
KW - PAH
KW - pastureland
KW - PM10
KW - PM2.5-10
KW - PM2.5
KW - temple
N1 - Accession Number: 15958477; Guor-Cheng Fang 1; Email Address: gcfang@sunrise.hk.edu.tw; Yuh-Shen Wu 1; Pi-Cheng Fu, Peter 2; Cheng-Nan Chang 3; Tse-Tsung Ho 3; Ming-Hsiang Chen 3; Affiliations: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung 433, Taiwan; 2: Division of Biochemical Toxicology National Center for Toxicological Research Jefferson, Arkansas 72079, USA; 3: Department of Environmental Science, Tunghai University Taichung 407, Taiwan; Issue Info: 2004, Vol. 22 Issue 6, p688; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Polycyclic aromatic compounds; Thesaurus Term: Hydrocarbons; Subject Term: Chemicals; Subject: Taiwan; Author-Supplied Keyword: PAH; Author-Supplied Keyword: pastureland; Author-Supplied Keyword: PM10; Author-Supplied Keyword: PM2.5-10; Author-Supplied Keyword: PM2.5; Author-Supplied Keyword: temple; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 13p; Illustrations: 3 Charts, 5 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Graham, David J.
AU - Staffa, Judy A.
AU - Shatin, Deborah
AU - Andrade, Susan E.
AU - Schech, Stephanie D.
AU - La Grenade, Lois
AU - Gurwitz, Jerry H.
AU - Chan, K. Arnold
AU - Goodman, Michael J.
AU - Platt, Richard
T1 - Incidence of Hospitalized Rhabdomyolysis in Patients Treated With Lipid-Lowering Drugs.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/12//12/1/2004
VL - 292
IS - 21
M3 - Article
SP - 2585
EP - 2590
SN - 00987484
AB - Context Lipid-lowering agents are widely prescribed in the United States. Reliable estimates of rhabdomyolysis risk with various lipid-lowering agents are not available. Objective To estimate the incidence of rhabdomyolysis in patients treated with different statins and fibrates, alone and in combination, in the ambulatory setting. Design, Setting, and Patients Drug-specific inception cohorts of statin and fibrate users were established using claims data from 11 managed care health plans across the United States. Patients with at least 180 days of prior health plan enrollment were entered into the cohorts between January 1, 1998, and June 30, 2001. Person-time was classified as monotherapy or combined statin-fibrate therapy. Main Outcome Measure Incidence rates of rhabdomyolysis per 10,000 person-years of treatment, number needed to treat, and relative risk of rhabdomyolysis. Results In 252 460 patients treated with lipid-lowering agents, 24 cases of hospitalized rhabdomyolysis occurred during treatment. Average incidence per 10,000 person-years for monotherapy with atorvastatin, pravastatin, or simvastatin was 0.44 (95% confidence interval [CI], 0.20-0.84); for cerivastatin, 5.34 (95% CI, 1.46-13.68); and for fibrate, 2.82 (95% CI, 0.58-8.24). By comparison, the incidence during unexposed person-time was 0 (95% CI, 0-0.48; P = .056). The incidence increased to 5.98 (95% CI, 0.72-216.0) for combined therapy of atorvastatin, pravastatin, or simvastatin with a fibrate, and to 1035 (95% CI, 389-2117) for combined cerivastatin-fibrate use. Per year of therapy, the number needed to treat to observe 1 case of rhabdomyolysis was 22,727 for statin monotherapy, 484 for older patients with diabetes mellitus who were treated with both a statin and fibrate, and ranged from 9.7 to 12.7 for patients who were treated with cerivastatin plus fibrate. Conclusions Rhabdomyolysis risk was similar and low for monotherapy with atorvastatin, pravastatin, and simvastatin; combined stati... [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHABDOMYOLYSIS
KW - STRIATED muscle -- Necrosis
KW - STATINS (Cardiovascular agents)
KW - THERAPEUTICS
KW - PUBLIC health
KW - MEDICAL care -- United States
KW - ENDOCRINE diseases
KW - DIABETICS
KW - Atorvastatin
KW - Cerivastatin
KW - Drug Reaction, Adverse
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW - Pravastatin
KW - Rhabdomyolysis
KW - Risk Assessment
KW - Simvastatin
N1 - Accession Number: 15226203; Graham, David J. 1 Staffa, Judy A. 1 Shatin, Deborah 1 Andrade, Susan E. 1 Schech, Stephanie D. 1 La Grenade, Lois 1 Gurwitz, Jerry H. 1 Chan, K. Arnold 1 Goodman, Michael J. 1 Platt, Richard 1; Affiliation: 1: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md (Drs Graham, Staffa, and La Grenade); Center for Health Care Policy and Evaluation, Eden Prairie, Minn (Dr Shatin and Ms Schech); Meyers Primary Care Institute, Fallon Foundation and the University of Massachusetts Medical School, Worcester (Drs Andrade and Gurwitz); Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School (Drs Chan and Platt), Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School (Dr Platt), and Department of Epidemiology, Harvard School of Public Health (Dr Chan), Boston, Mass; and HealthPartners Research Foundation, Minneapolis, Minn (Dr Goodman).; Source Info: 12/1/2004, Vol. 292 Issue 21, p2585; Subject Term: RHABDOMYOLYSIS; Subject Term: STRIATED muscle -- Necrosis; Subject Term: STATINS (Cardiovascular agents); Subject Term: THERAPEUTICS; Subject Term: PUBLIC health; Subject Term: MEDICAL care -- United States; Subject Term: ENDOCRINE diseases; Subject Term: DIABETICS; Author-Supplied Keyword: Atorvastatin; Author-Supplied Keyword: Cerivastatin; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Author-Supplied Keyword: Pravastatin; Author-Supplied Keyword: Rhabdomyolysis; Author-Supplied Keyword: Risk Assessment; Author-Supplied Keyword: Simvastatin; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106540718
T1 - Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.
AU - Graham DJ
AU - Staffa JA
AU - Shatin D
AU - Andrade SE
AU - Schech SD
AU - La Grenade L
AU - Gurwitz JH
AU - Chan KA
AU - Goodman MJ
AU - Platt R
AU - Graham, David J
AU - Staffa, Judy A
AU - Shatin, Deborah
AU - Andrade, Susan E
AU - Schech, Stephanie D
AU - La Grenade, Lois
AU - Gurwitz, Jerry H
AU - Chan, K Arnold
AU - Goodman, Michael J
AU - Platt, Richard
Y1 - 2004/12//12/1/2004
N1 - Accession Number: 106540718. Language: English. Entry Date: 20051118. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: FD-U-002067/FD/FDA HHS/United States. NLM UID: 7501160.
KW - Antilipemic Agents -- Adverse Effects
KW - Hospitalization
KW - Rhabdomyolysis -- Chemically Induced
KW - Rhabdomyolysis -- Epidemiology
KW - Adult
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Drug Therapy, Combination
KW - Female
KW - Incidence
KW - Male
KW - Middle Age
KW - Relative Risk
KW - Statins -- Adverse Effects
KW - United States
KW - Funding Source
KW - Human
SP - 2585
EP - 2590
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 292
IS - 21
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Lipid-lowering agents are widely prescribed in the United States. Reliable estimates of rhabdomyolysis risk with various lipid-lowering agents are not available.Objective: To estimate the incidence of rhabdomyolysis in patients treated with different statins and fibrates, alone and in combination, in the ambulatory setting.Design, Setting, and Patients: Drug-specific inception cohorts of statin and fibrate users were established using claims data from 11 managed care health plans across the United States. Patients with at least 180 days of prior health plan enrollment were entered into the cohorts between January 1, 1998, and June 30, 2001. Person-time was classified as monotherapy or combined statin-fibrate therapy.Main Outcome Measure: Incidence rates of rhabdomyolysis per 10,000 person-years of treatment, number needed to treat, and relative risk of rhabdomyolysis.Results: In 252,460 patients treated with lipid-lowering agents, 24 cases of hospitalized rhabdomyolysis occurred during treatment. Average incidence per 10,000 person-years for monotherapy with atorvastatin, pravastatin, or simvastatin was 0.44 (95% confidence interval [CI], 0.20-0.84); for cerivastatin, 5.34 (95% CI, 1.46-13.68); and for fibrate, 2.82 (95% CI, 0.58-8.24). By comparison, the incidence during unexposed person-time was 0 (95% CI, 0-0.48; P = .056). The incidence increased to 5.98 (95% CI, 0.72-216.0) for combined therapy of atorvastatin, pravastatin, or simvastatin with a fibrate, and to 1035 (95% CI, 389-2117) for combined cerivastatin-fibrate use. Per year of therapy, the number needed to treat to observe 1 case of rhabdomyolysis was 22,727 for statin monotherapy, 484 for older patients with diabetes mellitus who were treated with both a statin and fibrate, and ranged from 9.7 to 12.7 for patients who were treated with cerivastatin plus fibrate.Conclusions: Rhabdomyolysis risk was similar and low for monotherapy with atorvastatin, pravastatin, and simvastatin; combined statin-fibrate use increased risk, especially in older patients with diabetes mellitus. Cerivastatin combined with fibrate conferred a risk of approximately 1 in 10 treated patients per year.
SN - 0098-7484
AD - Office of of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md 20857, USA
U2 - PMID: 15572716.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106509117
T1 - Naltrexone and pharmacy benefit management.
AU - Harris KM
AU - Thomas C
Y1 - 2004/12//
N1 - Accession Number: 106509117. Language: English. Entry Date: 20050902. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9107051.
KW - Drug Utilization
KW - Insurance, Health
KW - Naltrexone
KW - Alcoholism -- Drug Therapy
KW - Drugs, Prescription
KW - Formularies
KW - Insurance, Health, Reimbursement
KW - Medicaid
KW - Pharmacy and Pharmacology
KW - Private Sector
KW - Public Sector
KW - United States Department of Veterans Affairs
SP - 11
EP - 29
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
JA - J ADDICT DIS
VL - 23
IS - 4
PB - Taylor & Francis Ltd
AB - Naltrexone was approved by the FDA in 1994 for the treatment of alcohol dependence. Despite the potential to make treatment more effective and accessible, naltrexone use remains low by almost any measure. While many of the factors responsible for the slow pace of diffusion are unique to naltrexone and to the organization and delivery of alcohol treatment services, other factors are the same as those that affect the use of prescription medications more generally. Access to third-party coverage and formulary inclusion are necessary conditions for the adoption and diffusion of any new pharmaceutical technology. This paper describes current issues in drug benefit design and formulary coverage decisions, reviews publicly available information on naltrexone coverage by large health insurance programs and pharmaceutical benefit management companies, and examines whether drug benefit design constitutes a barrier to naltrexone use. Our review suggests that naltrexone is widely covered on public and private health plan formularies, though restrictions on use (i.e., quantity limits, prior authorization) are common.
SN - 1055-0887
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD 20857; kharris@amhsa.gov
U2 - PMID: 15339711.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bobick, Thomas G.
T1 - Falls through Roof and Floor Openings and Surfaces, Including Skylights: 1992–2000.
JO - Journal of Construction Engineering & Management
JF - Journal of Construction Engineering & Management
Y1 - 2004/12//
VL - 130
IS - 6
M3 - Article
SP - 895
EP - 907
PB - American Society of Civil Engineers
SN - 07339364
AB - Fall-related occupational injuries and fatalities are still serious problems in the U.S. construction industry. Two Bureau of Labor Statistics databases—Census of Fatal Occupational Injuries and Survey of Occupational Injuries and Illnesses—were examined for 1992-2000. An important subset of falls-to-lower-level incidents is when workers fall through openings or surfaces, including skylights. A total of 605 fall-through fatalities occurred during 1992-2000. Also, 21,985 workers were injured seriously enough from fall-through incidents to miss a day away from work (DAFW). Fall-through injuries are among the most severe cases for median number of DAFW. Median DAFW were 35, 11, 25, 12, and 36 for fall-through roof and floor openings, roof and floor surfaces, and skylights, respectively, compared to 10 DAFW for all fall-to-lower-level incidents in all U.S. private industry. A conservative approach, which assumes that direct and indirect costs are equal, estimates a range of $55,000-$76,000 for the total cost of a 1998 DAFW fall-through injury. Current work practices should use commercial fall-prevention products to reduce the frequency and costs of fall-through incidents. These analyses have identified a subset of fall-related incidents that contribute to excessive costs to the U.S. construction industry. Researchers can use a systems approach on these incidents to identify contributing risk factors. Employers and practitioners can alert managers and work crews about these dangerous locations to eliminate these hazards that are often obvious and easy to rectify. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Construction Engineering & Management is the property of American Society of Civil Engineers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FALLS (Accidents)
KW - INDUSTRIAL hygiene
KW - BUILDING
KW - CONSTRUCTION industry
KW - WORK-related injuries
KW - UNITED States
KW - Construction site accidents
KW - Cost estimates
KW - Fatalities
KW - Injuries
KW - Occupational safety
N1 - Accession Number: 15074374; Bobick, Thomas G. 1; Email Address: txb4@cdc.gov; Affiliation: 1: PhD, CSP, Research Safety Engineer, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Rd., Mailstop H-G800, Morgantown, WV 26505-2888; Source Info: Dec2004, Vol. 130 Issue 6, p895; Subject Term: FALLS (Accidents); Subject Term: INDUSTRIAL hygiene; Subject Term: BUILDING; Subject Term: CONSTRUCTION industry; Subject Term: WORK-related injuries; Subject Term: UNITED States; Author-Supplied Keyword: Construction site accidents; Author-Supplied Keyword: Cost estimates; Author-Supplied Keyword: Fatalities; Author-Supplied Keyword: Injuries; Author-Supplied Keyword: Occupational safety; NAICS/Industry Codes: 236110 Residential building construction; Number of Pages: 13p; Document Type: Article
L3 - 10.1061/(ASCE)0733-9364(2004)130:6(895)
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106492617
T1 - Effect of viewing angle on luminance and contrast for a five-million-pixel monochrome display and a nine-million-pilel color liquid crystal display.
AU - Fifadara DH
AU - Averbukh A
AU - Channin DS
AU - Badano A
Y1 - 2004/12//
N1 - Accession Number: 106492617. Language: English. Entry Date: 20050729. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Computer/Information Science; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9100529.
KW - Computer Peripherals
KW - Data Display
KW - User-Computer Interface
KW - Radiographic Image Enhancement
KW - Light
KW - Evaluation Research
KW - Human
SP - 264
EP - 270
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
JA - J DIGIT IMAGING
VL - 17
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - Digital imaging systems used in radiology rely on electronic display devices to present images to human observers. Active-matrix liquid crystal displays (AMLCDs) continue to improve and are beginning to be considered for diagnostic image display. In spite of recent progress, AMLCDs are characterized by a change in luminance and contrast response with changes in viewing direction. In this article, we characterize high pixel density AMLCDs (a five-million-pixel monochrome display and a nine-million-pixel color display) in terms of the effect of viewing angle on their luminance and contrast response. We measured angular luminance profiles using a custom-made computer-controlled goniometric instrument and a conoscopic Fourier-optics instrument. We show the angular luminance response as a function of viewing angle, as well as the departure of the measured contrast from the desired response. Our findings indicate small differences between the five-million-pixel (5 MP) and the nine-million-pixel (9 MP) AMLCDs. The 9 MP shows lower variance in contrast with changes in viewing angle, whereas the 5 MP provides a slightly better GSDF compliance for off-normal viewing.
SN - 0897-1889
AD - Center for Devices and Radiological Health, Food and Drug Administration, 12720 Twinbrook Parkway, Rockville, MD 20857
U2 - PMID: 15692870.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Otto III, Charles S.
T1 - Letters to the Editor.
JO - Journal of Environmental Health
JF - Journal of Environmental Health
Y1 - 2004/12//
VL - 67
IS - 5
M3 - Letter
SP - 6
EP - 6
PB - National Environmental Health Association
SN - 00220892
AB - The article presents a letter to the editor about complex subject of environmental health preparedness.
KW - Environmental health
KW - Letters to the editor
N1 - Accession Number: 15176435; Otto III, Charles S. 1; Affiliations: 1: Captain U.S. Public Health Service Centers for Disease Control; Issue Info: Dec2004, Vol. 67 Issue 5, p6; Thesaurus Term: Environmental health; Subject Term: Letters to the editor; Number of Pages: 1p; Document Type: Letter; Full Text Word Count: 462
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DB - eih
ER -
TY - JOUR
AU - Kim, S.H.
AU - Lee, H.S.
AU - Lee, S.
AU - Cho, J.
AU - Ze, K.
AU - Sung, J.
AU - Kim, Y.C.
T1 - Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatotoxins
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2004/12//
VL - 95
IS - 2/3
M3 - Article
SP - 367
EP - 372
SN - 03788741
AB - Abstract: Hepatoprotective activity of Phellinus linteus was studied using H2O2- or galactosamine-injured primary cultures of rat hepatocytes as screening systems. The methanolic extract of the mycelial culture of Phellinus linteus significantly protected against hepatotoxins-induced toxicity in primary cultured rat hepatocytes as seen from the decreased level of glutamic pyruvic transaminase released from the injured hepatocytes. The methanolic extract of the mycelial culture of Phellinus linteus was subsequently fractionated with n-hexane, ethyl acetate, n-butanol and water. Among these fractions, 100μg/mL of the ethyl acetate fraction was the most active one. The relative protections were 68.9 ± 5.3% in H2O2-injured hepatocytes and 46.8 ± 3.9% in galactosamine-injured hepatocytes, respectively. The ethyl acetate fraction appeared to maintain the glutathione level which was decreased by the treatment of H2O2 or galactosamine and restored the level of RNA synthesis more than two times compared to galactosamine-injured hepatocytes. These results suggest that the ethyl acetate fraction of the mycelial culture of Phellinus linteus protects hepatocytes from H2O2- or galactosamine-induced injury by maintaining hepatic glutathione level and RNA synthesis as well. [Copyright &y& Elsevier]
AB - Copyright of Journal of Ethnopharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHELLINUS
KW - LIVER cells
KW - OLIGOPEPTIDES
KW - HEPATOTOXICOLOGY
KW - Galactosamine
KW - Glutathione
KW - H2O2
KW - Phellinus linteus
N1 - Accession Number: 18162220; Kim, S.H. 1 Lee, H.S. 2 Lee, S. 3 Cho, J. 3 Ze, K. 3 Sung, J. 4 Kim, Y.C. 1; Email Address: youngkim@plaza.snu.ac.kr; Affiliation: 1: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1, Shillim-Dong, Seoul 151-742, Republic of Korea 2: Department of Food Science and Technology, Seoul National Polytechnic University, Seoul 139-743, Republic of Korea 3: Herbal Medicine Evaluation Department, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea 4: Department of Biological Environment, Kangwon National University, Kangwon 200-701, Republic of Korea; Source Info: Dec2004, Vol. 95 Issue 2/3, p367; Subject Term: PHELLINUS; Subject Term: LIVER cells; Subject Term: OLIGOPEPTIDES; Subject Term: HEPATOTOXICOLOGY; Author-Supplied Keyword: Galactosamine; Author-Supplied Keyword: Glutathione; Author-Supplied Keyword: H2O2; Author-Supplied Keyword: Phellinus linteus; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jep.2004.08.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oh, Hyuncheol
AU - Kim, Do-Hoon
AU - Cho, Jung-Hee
AU - Kim, Youn-Chul
T1 - Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2004/12//
VL - 95
IS - 2/3
M3 - Article
SP - 421
EP - 424
SN - 03788741
AB - Abstract: Hepatoprotective activity-guided fractionation of the MeOH extract of Equisetum arvense L. (Equisetaceae) resulted in the isolation of two phenolic petrosins, onitin (1) and onitin-9-O-glucoside (2), along with four flavonoids, apigenin (3), luteolin (4), kaempferol-3-O-glucoside (5), and quercetin-3-O-glucoside (6). Among these, compounds 1 and 4 exhibited hepatoprotective activities on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, displaying EC50 values of 85.8±9.3μM and 20.2 ± 1.4μM, respectively. Silybin, used as a positive control, showed the EC50 value of 69.0±3.3μM. Compounds 1 and 4 also showed superoxide scavenging effects (IC50 =35.3 ± 0.2μM and 5.9 ± 0.3μM, respectively) and DPPH free radical scavenging effect (IC50 of 35.8±0.4μM and 22.7±2.8μM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine. [Copyright &y& Elsevier]
AB - Copyright of Journal of Ethnopharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVONOIDS
KW - FATTY acids
KW - ALTERNATIVE medicine
KW - TRADITIONAL medicine
KW - Antioxidants
KW - Equisetum arvense
KW - Flavonoids
KW - Hepatoprotective
KW - Phenolic petrosins
N1 - Accession Number: 18162227; Oh, Hyuncheol 1 Kim, Do-Hoon 2 Cho, Jung-Hee 2 Kim, Youn-Chul 3; Email Address: yckim@wonkwang.ac.kr; Affiliation: 1: Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea 2: Korea Food and Drug Administration, Seoul 122-704, South Korea 3: MRRC and College of Pharmacy, Wonkwang University, Iksan 570-749, South Korea; Source Info: Dec2004, Vol. 95 Issue 2/3, p421; Subject Term: FLAVONOIDS; Subject Term: FATTY acids; Subject Term: ALTERNATIVE medicine; Subject Term: TRADITIONAL medicine; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: Equisetum arvense; Author-Supplied Keyword: Flavonoids; Author-Supplied Keyword: Hepatoprotective; Author-Supplied Keyword: Phenolic petrosins; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jep.2004.08.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Moody, Joanna D.
AU - Freeman, James P.
AU - Brezna, Barbara
AU - Engesser, Karl-Heinrich
AU - Cerniglia, Carl E.
T1 - Evidence for the existence of PAH-quinone reductase and catechol-O-methyltransferase inMycobacterium vanbaaleniiPYR-1.
JO - Journal of Industrial Microbiology & Biotechnology
JF - Journal of Industrial Microbiology & Biotechnology
Y1 - 2004/12//
VL - 31
IS - 11
M3 - Article
SP - 507
EP - 516
PB - Springer Science & Business Media B.V.
SN - 13675435
AB - Polycyclic aromatic hydrocarbon (PAH) quinone reductase (PQR) and catechol-O-methyltransferase (COMT), from the PAH-degradingMycobacteriumvanbaaleniiPYR-1, were demonstrated to be constitutive enzymes located in the soluble fraction of cell extracts. PQR activities for the reduction of 9,10-phenanthrenequinone and 4,5-pyrene- quinone were 1.40±0.13 and 0.12±0.01 µmol min-1 mg-protein-1, respectively. The exogenous catechols alizarin, anthrarobin, 2,3-dihydroxynaphthalene and esculetin inhibited PQR activity. Anthrarobin (100 µM) and esculetin (100 µM) inhibited 4,5-pyrenequinone reduction by 64-92%. COMT was involved in theO-methylation of 1,2-dihydroxyphenanthrene to form 1-methoxy-2-hydroxyphenanthrene and 1,2-dimethoxyphenanthrene. Both pyrene and 1-hydroxypyrene were metabolized byM. vanbaaleniiPYR-1 to form 1-methoxypyrene, 1-methoxy-2-hydroxypyrene, 1-hydroxy-2-methoxypyrene and 1,2-dimethoxypyrene. Among the catechols tested, anthrarobin showed the highest COMT activity (1.06±0.04 nmol/30 min-1 mg-protein-1). These results suggest that the PQR and COMT activities ofM. vanbaaleniiPYR-1 may play an important role in the detoxification of PAH catechols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Industrial Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYPHENOLS
KW - PLANT pigments
KW - CATECHOL
KW - QUINONE
KW - MATERIA medica
KW - COAL-tar colors
KW - Catechol-O-methyltransferase
KW - Polycyclic aromatic hydrocarbon
KW - Quinone reductase
N1 - Accession Number: 15806234; Kim, Yong-Hak 1 Moody, Joanna D. 1 Freeman, James P. 2 Brezna, Barbara 3 Engesser, Karl-Heinrich 4 Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd., Jefferson, AR 72079, USA. 2: Division of Chemistry, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA. 3: Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovak Republic. 4: Abteilung Biologische Abluftreinigung, ISWA, Universität Stuttgart, Stuttgart, Germany.; Source Info: Dec2004, Vol. 31 Issue 11, p507; Subject Term: POLYPHENOLS; Subject Term: PLANT pigments; Subject Term: CATECHOL; Subject Term: QUINONE; Subject Term: MATERIA medica; Subject Term: COAL-tar colors; Author-Supplied Keyword: Catechol-O-methyltransferase; Author-Supplied Keyword: Polycyclic aromatic hydrocarbon; Author-Supplied Keyword: Quinone reductase; Number of Pages: 10p; Document Type: Article
L3 - 10.1007/s10295-004-0178-x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vo, Evanly
T1 - Application of Colorimetric Indicators and Thermo-Hand Method to Determine Base Permeation Through Chemical Protective Gloves.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/12//
VL - 1
IS - 12
M3 - Article
SP - 799
EP - 805
SN - 15459624
AB - The aim of this study was to assess the use of colorimetric indicator pads and the thermo-hand method for detection of inorganic/organic base permeation of chemical protective gloves under simulated in-use conditions. Breakthrough times for four types of gloves were determined based on the color change of pads and ranged from 3 to 10 min for butylamine, from 4 min to > 4 hours for diisopropylamine, from 6 min to > 4 hours for triethylamine, and > 4 hours for sodium hydroxide. Quantification was performed for butylamine, diisopropylamine, and triethylamine by gas chromatography following solvent desorption. These chemicals exhibited > 99%adsorption on the pads at spiking levels of 1.08–1.11μg for each base. The recovery for the system was calculated for each chemical, with results ranging from 50–74%(RSD≤5%) for these bases over the spiking range 0.22–1.11μg. The quantitative mass of the bases on the pads at the time of breakthrough detection ranged from 118–121, 117–120, and 109–116μg/cm2for butylamine, diisopropylamine, and triethylamine, respectively. The thermo-hand test method and base indicators together should find utility in detecting, collecting, and quantitatively analyzing base permeation samples under simulated in-use conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLORIMETRIC analysis
KW - PROTECTIVE coverings
KW - QUALITATIVE chemical analysis
KW - THERMOCHEMISTRY
KW - SAFETY
KW - breakthrough times
KW - chemical protective gloves
KW - colorimetric indicators
KW - quantitative analysis
KW - safety
KW - thermo-hand method
N1 - Accession Number: 14797066; Vo, Evanly 1; Email Address: eav8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania; Source Info: Dec2004, Vol. 1 Issue 12, p799; Subject Term: COLORIMETRIC analysis; Subject Term: PROTECTIVE coverings; Subject Term: QUALITATIVE chemical analysis; Subject Term: THERMOCHEMISTRY; Subject Term: SAFETY; Author-Supplied Keyword: breakthrough times; Author-Supplied Keyword: chemical protective gloves; Author-Supplied Keyword: colorimetric indicators; Author-Supplied Keyword: quantitative analysis; Author-Supplied Keyword: safety; Author-Supplied Keyword: thermo-hand method; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15459620490887048
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14797066&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dababneh, Awwad
AU - Lowe, Brian
AU - Krieg, Ed
AU - Kong, Yong-Ku
AU - Waters, Thomas
T1 - A Checklist for the Ergonomic Evaluation of Nonpowered Hand Tools.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2004/12//
VL - 1
IS - 12
M3 - Article
SP - D135
EP - D145
SN - 15459624
AB - A checklist was developed to evaluate nonpowered hand tools for basic features related to good ergonomic tool design. The checklist contains 16 items to which a yes/no response is required. The checklist is intended to be used by tradespersons and is written in clear, simple language. This column reports on a study conducted to examine the reliability of the checklist questions in identifying the presence or absence of the basic ergonomic design features that are believed to be important for nonpowered hand tools. Using the checklist, 14 ergonomists and 126 carpenters evaluated 18 typical hand tools. Agreement among the carpenters and ergonomists was high for most of the checklist items. A few checklist questions were associated with relatively low agreement among raters in terms of the presence or absence of a design feature. Lack of agreement between raters indicates that the criterion was not explicit or that users had difficulty identifying whether the tool satisfied the particular criterion. The majority of the 18 hand tools evaluated were deemed to be lacking in multiple highly important ergonomic design features. Additional studies are being conducted to make appropriate revisions to the checklist criteria based on quantitative measures of musculoskeletal loading. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERGONOMICS
KW - TOOLS -- Design & construction
KW - EVALUATION
KW - TOOLS
KW - CARPENTERS
KW - IMPLEMENTS, utensils, etc.
KW - WORK environment
N1 - Accession Number: 14797070; Dababneh, Awwad 1 Lowe, Brian 2 Krieg, Ed 2 Kong, Yong-Ku 2 Waters, Thomas 2; Affiliation: 1: Department of Industrial Engineering University of Jordan, Amman, Jordan 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Dec2004, Vol. 1 Issue 12, pD135; Subject Term: ERGONOMICS; Subject Term: TOOLS -- Design & construction; Subject Term: EVALUATION; Subject Term: TOOLS; Subject Term: CARPENTERS; Subject Term: IMPLEMENTS, utensils, etc.; Subject Term: WORK environment; NAICS/Industry Codes: 238350 Finish Carpentry Contractors; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/15459620490883150
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106570066
T1 - Application of colorimetric indicators and thermo-hand method to determine base permeation through chemical protective gloves.
AU - Vo E
Y1 - 2004/12//
N1 - Accession Number: 106570066. Language: English. Entry Date: 20050128. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Gloves -- Evaluation
KW - Occupational Exposure
KW - Chromatography, Gas
KW - Simulations
KW - Human
SP - 799
EP - 805
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 1
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The aim of this study was to assess the use of colorimetric indicator pads and the thermo-hand method for detection of inorganic/organic base permeation of chemical protective gloves under simulated in-use conditions. Breakthrough times for four types of gloves were determined based on the color change of pads and ranged from 3 to 10 min for butylamine, from 4 min to > 4 hours for diisopropylamine, from 6 min to > 4 hours for triethylamine, and > 4 hours for sodium hydroxide. Quantification was performed for butylamine, diisopropylamine, and triethylamine by gas chromatography following solvent desorption. These chemicals exhibited > 99% adsorption on the pads at spiking levels of 1.08-1.11 microg for each base. The recovery for the system was calculated for each chemical, with results ranging from 50-74% (RSD
PB - Springer Science & Business Media B.V.
AB - Infant mortality review (IMR), the forerunner of fetal and infant mortality review (FIMR), emerged at the national level in the mid-1980s as a promising method to improve understanding of local factors contributing to infant mortality and to motivate community response. Building on federal efforts to enhance data capacity and early state and local infant mortality case review studies, the federal Maternal and Child Health Bureau (MCHB) initiated its IMR Program in 1988. Key actions taken to refine and diffuse the IMR/FIMR method include forging a public-private partnership between MCHB and the American College of Obstetricians and Gynecologists in 1990 to develop the National Fetal and Infant Mortality Review Program, recruiting prominent leaders to advocate for FIMR, seeding community projects in geographically dispersed states and localities, and routinely reporting best practices information to the field. In concert with the articulation of core public health functions and a growing emphasis on accountability, attention at the national level has turned to promoting and institutionalizing FIMR in state systems. Efforts are underway in states to build on the FIMR model and coordinate multiple maternal and child health-related review programs. Increasingly, FIMR is recognized as a strategy for contributing to implementation of the core public health functions of assessment, policy development, and quality assurance. The recent national evaluation of FIMR sheds new light on the role of FIMR in community and state maternal and child health systems and marks a new phase in the evolution of FIMR.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland; akoontz@hrsa.gov
U2 - PMID: 15623142.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106594901&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106594932
T1 - FIMR and other mortality reviews as public health tools for strengthening maternal and child health systems in communities: where do we need to go next?
AU - Hutchins E
AU - Grason H
AU - Handler A
Y1 - 2004/12//
N1 - Accession Number: 106594932. Language: English. Entry Date: 20050318. Revision Date: 20150820. Publication Type: Journal Article; research. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. Grant Information: Supported in part by grant U08MC00136 from the Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services. NLM UID: 9715672.
KW - Health Policy
KW - Infant Mortality -- Evaluation
KW - Interinstitutional Relations
KW - Maternal Mortality -- Evaluation
KW - Maternal-Child Health
KW - Public Health Administration
KW - Child Mortality
KW - Collaboration
KW - Comparative Studies
KW - Data Analysis -- Methods
KW - Funding Source
KW - Organizational Structure
KW - Outcomes (Health Care)
KW - Quality Improvement -- Methods
KW - Record Review -- Methods
KW - Record Review -- Standards
KW - Sentinel Event -- Evaluation
KW - Human
SP - 259
EP - 268
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 8
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - This article examines FIMR in relationship to two other maternal and child health mortality reviews-child fatality review (CFR) and maternal mortality review (MMR), and explores how their approaches to reviewing deaths can complement one another. Identifying opportunities for collaboration among these case review methodologies may lead to greater efficiencies at the local and state levels and strengthen the case review approach as a public health tool for improving maternal and child health outcomes. To enable comparative analysis, a table was constructed that identifies the purpose, structure, and process features of each case review approach. This was followed by an examination of two possible ways to improve maternal and child mortality review processes in states: 1) better coordination; and 2) improving each individual process through adapting and adopting promising practices from the others. A discussion is also provided of the state Title V role in facilitating both the coordination of reviews and the process of sharing best practices. Given the similarities that exist among the three MCH mortality reviews, it is important to view each review as one component of a larger system of maternal and child health death reviews. Implementing widely the recommendations generated by these reviews may increase the likelihood of improvements in services and systems on behalf of women and children.
SN - 1092-7875
AD - Chief, Perinatal and Women's Health Branch, Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Parklawn Building -- Room 18-12, 5600 Fishers Lane, Rockville, MD 20857; ehutchins@hrsa.gov
U2 - PMID: 15623148.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106598269
T1 - Reader variability in mammography and its implications for expected utility over the population of readers and cases.
AU - Wagner RF
AU - Beam CA
AU - Beiden SV
Y1 - 2004/12//Nov/Dec2004
N1 - Accession Number: 106598269. Language: English. Entry Date: 20050325. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8109073.
KW - Breast Neoplasms -- Diagnosis
KW - Mammography
KW - Descriptive Statistics
KW - Female
KW - P-Value
KW - ROC Curve
KW - Human
SP - 561
EP - 572
JO - Medical Decision Making
JF - Medical Decision Making
JA - MED DECIS MAKING
VL - 24
IS - 6
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - The multiple-reader, multiple-case (MRMC) approach to receiver operating characteristic (ROC) analysis is becoming the dominant assessment paradigm in medical imaging. Its most common version involves having many readers read every patient case in the study, a critical feature since differences among competing imaging modalities are often dominated by differences in reader performance. The present authors have carried out MRMC ROC analysis on a uniquely large data set for mammography. The analysis quantifies the great range of observed reader skill in that data set. It also demonstrates that the sample sizes are sufficiently large that the conclusions generalize to the populations sampled here with little uncertainty from the finite sample size. A schematic approach to bracketing the utility matrix is then used to study trends in the resulting expected utility functions that correspond to the range of observed ROC curves. This is done for both the screening and the diagnostic context. The results raise 2 hypotheses for further investigation. First, it is possible that the present ambiguity surrounding the effectiveness of mammography is due in part to the observed range of reader skills and corresponding expected utility functions. Second, it is possible that computer-assisted modalities for mammography may lead to improvements in the expected utility function not only for screening but also in the diagnostic context, especially for the lower performing readers.
SN - 0272-989X
AD - Office of Science and Technology, Center for Devices & Radiological Health, Food and Drug Administration, Rockville, MD 20850; rfw@cdrh.fda.gov
U2 - PMID: 15534338.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Al-Khaldi, S.F.
AU - Myers, K.M.
AU - Rasooly, A.
AU - Chizhikov, V.
T1 - Genotyping of Clostridium perfringens toxins using multiple oligonucleotide microarray hybridization
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2004/12//
VL - 18
IS - 6
M3 - Article
SP - 359
EP - 367
SN - 08908508
AB - A microarray-based method for characterization of six Clostridium perfringens toxin genes: iA (iota toxin), cpa (alpha toxin), cpe (enterotoxin E), etxD (epsilon toxin), cpb1 (beta toxin 1),and cpb2 (beta toxin 2) was developed and evaluated using 17 C. perfringens isolates. Three individual oligonucleotide probes (oligoprobes), complementary to the unique sequences of each toxin gene, were designed and immobilized on a surface of aldehyde-coated glass slides. Multiplex PCR was used to simultaneously amplify DNA target regions of all six genes. Single-stranded DNA (ssDNA) samples for microarray analysis were prepared by following a primer extension of amplicons in the presence of one primer. Fluorescent moieties (Cy3) were incorporated into the ssDNA by chemical modification of guanine bases. The presence of toxin genes in C. perfringens was established by hybridization of the fluorescently labeled ssDNA representing different samples to the microarray gene-specific oligoprobes. Results of the study showed sensitivity and specificity of genotyping C. perfringens using multiple microarray-based assays. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM
KW - TOXINS
KW - BIOLOGY
KW - OLIGONUCLEOTIDES
KW - Clostridium perfringens
KW - DNA microarray
KW - Multiplex PCR
N1 - Accession Number: 14714746; Al-Khaldi, S.F.; Email Address: sufian.al-khaldi@cfsan.fda.gov Myers, K.M. 1 Rasooly, A. 1 Chizhikov, V. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Source Info: Dec2004, Vol. 18 Issue 6, p359; Subject Term: CLOSTRIDIUM; Subject Term: TOXINS; Subject Term: BIOLOGY; Subject Term: OLIGONUCLEOTIDES; Author-Supplied Keyword: Clostridium perfringens; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: Multiplex PCR; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mcp.2004.05.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guerra de Hoyos, Juan Antonio
AU - Martín, Maria del Carmen Andrés
AU - Leon, Elena Bassas y Baena de
AU - Lopez, Miguel Vigára
AU - López, Teresa Molina
AU - Morilla, Francisco Antonio Verdugo
AU - Moreno, Maria José González
T1 - Randomised trial of long term effect of acupuncture for shoulder pain
JO - Pain (03043959)
JF - Pain (03043959)
Y1 - 2004/12//
VL - 112
IS - 3
M3 - Article
SP - 289
EP - 298
SN - 03043959
AB - Abstract: The objective of the study is to compare the efficacy of electro-acupuncture with placebo-acupuncture for the treatment of shoulder pain. This study comprised of a prospective, randomized, placebo controlled trial, with independent evaluator set in a Public primary care clinic in Spain. The participants are patients aged from 25 to 83 years with shoulder pain. Patients were randomly allocated to two treatments over eight weeks, with electro-acupuncture or skin non-penetrating placebo-acupuncture, both able to take diclofenac if needed for intense pain. Primary outcome measure was the difference between groups in pain intensity (visual analogue scale—VAS). Secondary outcomes were differences between groups in pain intensity measured by Lattinen index, in range of motion (goniometer), functional ability (SPADI), quality of life (COOP-WONCA charts), NSAIDS intake, credibility (Borkoveck and Nau scale) and global satisfaction (10 points analogue scale). Assessments were performed before, during and three and six months after treatment. At six month follow-up after treatment the acupuncture group showed a significantly greater improvement in pain intensity compared with the control group [VAS mean difference 2.0 (95% CI 1.2–2.9)]. The acupuncture group had consistently better results in every secondary outcome measure than the control group. Acupuncture is an effective long-term treatment for patients with shoulder pain (from soft tissues lesions) in a primary care setting. [Copyright &y& Elsevier]
AB - Copyright of Pain (03043959) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACUPUNCTURE
KW - ALTERNATIVE medicine
KW - SHOULDER pain
KW - CLINICAL trials
KW - Acupuncture
KW - Electro-acupuncture
KW - Randomised controlled trial
KW - Shoulder pain
N1 - Accession Number: 15816416; Guerra de Hoyos, Juan Antonio 1; Email Address: med010042@saludalia.es Martín, Maria del Carmen Andrés 2 Leon, Elena Bassas y Baena de 3,4; Email Address: turku62@hotmail.com Lopez, Miguel Vigára 5 López, Teresa Molina 6 Morilla, Francisco Antonio Verdugo 7; Email Address: faverdugo@hotmail.com Moreno, Maria José González 8; Email Address: mjgonza@hus.es; Affiliation: 1: Andalusia Public Health Service, C/La Maria 26, DP 41008 Sevilla, Spain 2: C/Avda Eduardo Dato no. 54 3° B DP 41005, Sevilla, Spain 3: Analysis Department, Riotinto Hospital, Andalucia Public Health Service, Huelva, Spain 4: C/Pastor y Landero 23-25, 2° A. DP 41001 Sevilla, Spain 5: Andalusia Public Health Service, Distrito Sanitario Este-Sur, Calle Greco s\n, Sevilla, Spain 6: Andalusia Public Health Service, Sevilla Primary Health Care Pharmacist, C/Greco s\n, Sevilla, Spain 7: C/Cardenal Rodrigo de Castro n°5, 1° Puerta 5, DP 41005, Seville, Spain 8: Nursing and Physiotherapy Department, Health Sciences School, Sevilla University, Avda Sanchez Pizjuan s/n 41009 Sevilla, Spain; Source Info: Dec2004, Vol. 112 Issue 3, p289; Subject Term: ACUPUNCTURE; Subject Term: ALTERNATIVE medicine; Subject Term: SHOULDER pain; Subject Term: CLINICAL trials; Author-Supplied Keyword: Acupuncture; Author-Supplied Keyword: Electro-acupuncture; Author-Supplied Keyword: Randomised controlled trial; Author-Supplied Keyword: Shoulder pain; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.pain.2004.08.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104740565
T1 - Randomised trial of long term effect of acupuncture for shoulder pain.
AU - Guerra de Hoyos, Juan Antonio
AU - Andrés Martín, Maria del Carmen
AU - Bassas y Baena de Leon, Elena
AU - Vigára Lopez, Miguel
AU - Molina López, Teresa
AU - Verdugo Morilla, Francisco Antonio
AU - González Moreno, Maria José
Y1 - 2004/12//
N1 - Accession Number: 104740565. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 7508686.
KW - Acupuncture -- Methods
KW - Shoulder Pain -- Therapy
KW - Time
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Analysis of Variance
KW - Demography
KW - Double-Blind Studies
KW - Female
KW - Prospective Studies
KW - Human
KW - Male
KW - Middle Age
KW - Pain Measurement -- Methods
KW - Patient Satisfaction
KW - Quality of Life
KW - Time Factors
KW - Treatment Outcomes
SP - 289
EP - 298
JO - Pain (03043959)
JF - Pain (03043959)
JA - PAIN
VL - 112
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0304-3959
AD - Andalusia Public Health Service, C/La Maria 26, DP 41008 Sevilla, Spain. med010042@saludalia.es
U2 - PMID: 15561384.
DO - 10.1016/j.pain.2004.08.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104740565&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stamatas, Georgios N.
AU - Zmudzka, Barbara Z.
AU - Kollias, Nikiforos
AU - Beer, Janusz Z.
T1 - Non-Invasive Measurements of Skin Pigmentation In Situ.
JO - Pigment Cell Research
JF - Pigment Cell Research
Y1 - 2004/12//
VL - 17
IS - 6
M3 - Article
SP - 618
EP - 626
PB - Wiley-Blackwell
SN - 08935785
AB - Objective in situ measurements of skin pigmentation are needed for accurate documentation of pigmentation disorders, in studies of constitutive and induced skin pigmentation, for testing of the efficacy of pro-pigmentation or de-pigmentation agents, etc. Non-invasive instrumental measurements of skin pigmentation have been used for many decades. All are based on the ability of melanin to attenuate light. However, hemoglobin in dermal capillaries also attenuates light and needs to be accounted for when pigmentation is assessed. The methods under consideration include: (a) single point measurements, in which light reflected from a defined skin area is collected and a pigment index is calculated representing the average pigmentation over the examined area, and (b) imaging methods that attempt to generate a concentration distribution map of melanin pigment for the skin area being imaged. In this article, we describe the potentials and the limitations of the different approaches to both single point and imaging methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pigment Cell Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN skin color
KW - MELANINS
KW - REFLECTANCE spectroscopy
KW - PIGMENTATION disorders
KW - NONINVASIVE diagnostic tests
KW - Imaging
KW - In vivo
KW - Melanin
KW - Reflectance
KW - Spectroscopy
N1 - Accession Number: 15026447; Stamatas, Georgios N. 1 Zmudzka, Barbara Z. 2 Kollias, Nikiforos 1 Beer, Janusz Z. 2; Email Address: janusz.beer@fda.hhs.gov; Affiliation: 1: Methods and Models Development, Johnson and Johnson Consumer Products, Skillman, NJ, USA 2: Center for Devices and Radiological Health, Food and Drug Administration, 12720 Twinbrook Parkway, Rockville, MD, USA; Source Info: Dec2004, Vol. 17 Issue 6, p618; Subject Term: HUMAN skin color; Subject Term: MELANINS; Subject Term: REFLECTANCE spectroscopy; Subject Term: PIGMENTATION disorders; Subject Term: NONINVASIVE diagnostic tests; Author-Supplied Keyword: Imaging; Author-Supplied Keyword: In vivo; Author-Supplied Keyword: Melanin; Author-Supplied Keyword: Reflectance; Author-Supplied Keyword: Spectroscopy; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0749.2004.00204.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SL Archer
AU - KJ Greenlund
AU - R Valdez
AU - ML Casper
AU - S Rith-Najarian
AU - JB Croft
T1 - Differences in food habits and cardiovascular disease risk factors among Native Americans with and without diabetes: the Inter-Tribal Heart Project .
JO - Public Health Nutrition
JF - Public Health Nutrition
Y1 - 2004/12//
VL - 7
IS - 8
M3 - Article
SP - 1025
EP - 1032
SN - 13689800
AB - Objective: To examine differences in food habits among Native Americans with and without diabetes.Design: A cross-sectional epidemiological study in which participants underwent a physical examination and answered an extensive interviewer-administered questionnaire to assess differences in food servings, preparation and eating habits.Setting/participants: Participants aged =25 years were randomly selected from three reservations in Minnesota and Wisconsin. There were 990 persons without diabetes, 294 with a prior diagnosis of diabetes, and 80 with fasting glucose >125?mg?dl-1 but no prior diabetes diagnosis.Results: Persons with prior diabetes diagnosis were less likely than those without diabetes to report eating fast-food meals two or more times per week, eat visible fat on meat or the skin on poultry, eat fried chicken or fried fish, to add fat to cooked vegetables and drink whole milk. Persons with previously undiagnosed diabetes were more likely than previously diagnosed persons to report eating fast-food meals two or more times per week, eat visible fat on meat and the skin on poultry, drink whole milk and eat fried fish, but were less likely to drink low-fat milk. Previously undiagnosed persons were more likely than either diagnosed persons or persons without diabetes to consume lard from cooked foods and use it when cooking.Conclusion: Persons with diagnosed diabetes showed healthier eating patterns than those without diabetes, while undiagnosed persons showed some less favourable patterns. Because virtually all persons with diabetes in these communities receive nutrition education, the results suggest that nutrition education programmes for diabetics may be associated with healthier eating patterns. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Nutrition is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETIC acidosis
KW - DIABETES
KW - FOOD habits
KW - MALNUTRITION
N1 - Accession Number: 18401020; SL Archer 1 KJ Greenlund 2 R Valdez 3 ML Casper 2 S Rith-Najarian 4 JB Croft 2; Affiliation: 1: Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA 2: ment of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA, 1 , Cardiovascular Health Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-47, Atlanta, GA 30341-3717, USA 3: ment of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA, 1 , Cardiovascular Health Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-47, Atlanta, GA 30341-3717, USA, 2 , Division of Diabetes Translation, Atlanta, GA, USA 4: ment of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA, 1 , Cardiovascular Health Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-47, Atlanta, GA 30341-3717, USA, 2 , Division of Diabetes Translation, Atlanta, GA, USA, 3 , Bemidji Area Indian Health Service, Bemidji, MN, USA; Source Info: Dec2004, Vol. 7 Issue 8, p1025; Subject Term: DIABETIC acidosis; Subject Term: DIABETES; Subject Term: FOOD habits; Subject Term: MALNUTRITION; Number of Pages: 8p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Jeon, Dae Hoon
AU - Lee, Kwang Ho
AU - Park, Hyun Jin
T1 - The effects of irradiation on physicochemical characteristics of PET packaging film
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2004/12//
VL - 71
IS - 5
M3 - Article
SP - 1059
EP - 1064
SN - 0969806X
AB - The effects of γ-irradiation on physicochemical characteristics of biaxially stretched poly(ethylene terephthalate) (PET) packaging film were investigated in the range of 0–200 kGy. The diethylene glycol (DEG) contents in PET chains were increased at the low doses, 5 and 10 kGy, while these values were decreased at high doses, in the range of 30–200 kGy. Molecular weights, intrinsic viscosity and carboxy end group contents decreased slightly after 60 kGy dose. Permeability, thermal properties, color, haze and surface resistivity on γ-irradiation of oriented PET films were not significantly affected. Although some of the effects were measurable, they have no significance with respect to the use of PET for packaging of foods or medical devices to be irradiated. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IRRADIATION
KW - PERMEABILITY
KW - THIN films
KW - VISCOSITY
KW - Irradiation
KW - PET
KW - Physicochemical characteristics
KW - Poly(ethylene terephthalate)
N1 - Accession Number: 14748472; Jeon, Dae Hoon 1,2 Lee, Kwang Ho 2; Email Address: khlee@kfda.go.kr Park, Hyun Jin 1,3; Email Address: hjpark@korea.ac.kr; Affiliation: 1: Graduate School of Biotechnology, Korea University, 1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, South Korea 2: Food Packaging Division, Korea Food and Drug Administration (KFDA), 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, South Korea 3: Department of Packaging Science, Clemson University, Clemson SC 29634-0370, USA; Source Info: Dec2004, Vol. 71 Issue 5, p1059; Subject Term: IRRADIATION; Subject Term: PERMEABILITY; Subject Term: THIN films; Subject Term: VISCOSITY; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: PET; Author-Supplied Keyword: Physicochemical characteristics; Author-Supplied Keyword: Poly(ethylene terephthalate); NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.radphyschem.2003.10.009
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ER -
TY - JOUR
AU - Contrera, Joseph F.
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Benz, R. Daniel
T1 - Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2004/12//
VL - 40
IS - 3
M3 - Article
SP - 185
EP - 206
SN - 02732300
AB - Abstract: Estimating the maximum recommended starting dose (MRSD) of a pharmaceutical for phase I human clinical trials and the no observed effect level (NOEL) for non-pharmaceuticals is currently based exclusively on an extrapolation of the results of animal toxicity studies. This process is inexact and requires the results of toxicity studies in multiple species (rat, dog, and monkey) to identify the no observed adverse effect level (NOAEL) and most sensitive test species. Multiple uncertainty (safety) factors are also necessary to compensate for incompatibility and uncertainty underlying the extrapolation of animal toxicity to humans. The maximum recommended daily dose for pharmaceuticals (MRDD) is empirically derived from human clinical trials. The MRDD is an estimated upper dose limit beyond which a drug’s efficacy is not increased and/or undesirable adverse effects begin to outweigh beneficial effects. The MRDD is essentially equivalent to the NOAEL in humans, a dose beyond which adverse (toxicological) or undesirable pharmacological effects are observed. The NOAEL in test animals is currently used to estimate the safe starting dose in human clinical trials. MDL QSAR predictive modeling of the human MRDD may provide a better, simpler and more relevant estimation of the MRSD for pharmaceuticals and the toxic dose threshold of chemicals in humans than current animal extrapolation based risk assessment models and may be a useful addition to current methods. A database of the MRDD for over 1300 pharmaceuticals was compiled and modeled using MDL QSAR software and E-state and connectivity topological descriptors. MDL QSAR MRDD models were found to have good predictive performance with 74–78% of predicted MRDD values for 120 internal and 160 external validation compounds falling within a range of ±10-fold the actual MRDD value. The predicted MRDD can be used to estimate the MRSD for pharmaceuticals in phase I clinical trials with the addition of a 10-fold safety factor. For non-pharmaceutical chemicals any compound-related effect can be considered an undesirable and adverse toxicological effect and the predicted MRDD can be used to estimate the NOEL with the addition of an appropriate safety factor. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Toxicology
KW - Clinical trials
KW - Clinical medicine
KW - Medical experimentation on humans
KW - E-state descriptors
KW - In silico modeling
KW - Maximum recommended daily dose
KW - Maximum recommended safe starting dose
KW - No observed adverse effect level
KW - Phase 1 clinical trials
KW - Predictive modeling
KW - Predictive toxicology
KW - Quantitative structure activity relationship
KW - Safety factors
N1 - Accession Number: 15424452; Contrera, Joseph F.; Email Address: contrerajf@cder.fda.gov; Matthews, Edwin J. 1; Kruhlak, Naomi L. 1; Benz, R. Daniel 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research (HFD-901), Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 5600 Fishers Lane, Rockville, MD 20857, USA; Issue Info: Dec2004, Vol. 40 Issue 3, p185; Thesaurus Term: RESEARCH; Thesaurus Term: Toxicology; Subject Term: Clinical trials; Subject Term: Clinical medicine; Subject Term: Medical experimentation on humans; Author-Supplied Keyword: E-state descriptors; Author-Supplied Keyword: In silico modeling; Author-Supplied Keyword: Maximum recommended daily dose; Author-Supplied Keyword: Maximum recommended safe starting dose; Author-Supplied Keyword: No observed adverse effect level; Author-Supplied Keyword: Phase 1 clinical trials; Author-Supplied Keyword: Predictive modeling; Author-Supplied Keyword: Predictive toxicology; Author-Supplied Keyword: Quantitative structure activity relationship; Author-Supplied Keyword: Safety factors; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.yrtph.2004.08.004
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ER -
TY - JOUR
AU - Carrington, C.D.
AU - Montwill, B.
AU - Bolger, P.M.
T1 - An intervention analysis for the reduction of exposure to methylmercury from the consumption of seafood by women of child-bearing age
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2004/12//
VL - 40
IS - 3
M3 - Article
SP - 272
EP - 280
SN - 02732300
AB - Abstract: A previously developed exposure model was used [Risk Anal. 22 (2002) 689] to assess the effectiveness of various advisory scenarios on minimizing mercury (Hg) blood levels via the consumption of commercial seafood, both finfish and shellfish. This exposure model was developed to predict levels of Hg in blood in women of child-bearing age in the US based on the frequency of seafood consumption, the amount of seafood consumed per serving, and the types of seafood consumed. Steady-state relationships that employed descriptive statistics to account for toxicokinetic variation were used to predict levels of Hg in blood. The model incorporates an uncertainty dimension that is intended to represent the range of plausible interpretations of the data. The predictability of the model was confirmed via the use of National Health and Nutrition Examination Survey (NHANES) blood Hg data. In the present analysis, the model was used to predict the impact of limitations in the amount or types of seafood consumed on blood Hg levels. Specifically, simulations for various advisory scenarios were developed on the basis of limitations on total consumption of seafood, elimination of the consumption of certain species altogether, and/or a combination of both. In the baseline model, the median (uncertainty) estimates for the 50th, 95th, and 99th per capita population percentiles were 1.25, 8.2, and 16.1ppb blood Hg, respectively. After restriction of seafood consumption to no more than 12oz/week, the median (uncertainty) estimates for the 50th, 95th, and 99th per capita population percentiles were 1.22, 6.8, and 10.6ppb blood Hg, respectively. Elimination of MeHg species, with average concentrations above 0.6ppm, resulted in very modest decrements in Hg blood levels, in comparison to either the baseline or the reduced consumption scenarios. These results suggest that strategies to reduce MeHg exposure by reducing the amount of fish consumed (e.g., 12 oz/week) are more effective at eliminating the high end of the exposure distribution than are strategies intended to change the types of fish consumed. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Methylmercury
KW - Population
KW - Organomercury compounds
KW - Blood
KW - Advisory
KW - Fish consumption
N1 - Accession Number: 15424459; Carrington, C.D.; Email Address: cdc@cfsan.fda.gov; Montwill, B. 1; Bolger, P.M. 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA; Issue Info: Dec2004, Vol. 40 Issue 3, p272; Thesaurus Term: Methylmercury; Thesaurus Term: Population; Subject Term: Organomercury compounds; Subject Term: Blood; Author-Supplied Keyword: Advisory; Author-Supplied Keyword: Fish consumption; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.yrtph.2004.07.006
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ER -
TY - JOUR
AU - Carman, Robert J.
AU - Simon, Mary Alice
AU - Fernández, Haydée
AU - Miller, Margaret A.
AU - Bartholomew, Mary J.
T1 - Ciprofloxacin at low levels disrupts colonization resistance of human fecal microflora growing in chemostats
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2004/12//
VL - 40
IS - 3
M3 - Article
SP - 319
EP - 326
SN - 02732300
AB - Abstract: We studied the in vitro effects of a range of ciprofloxacin (CI) concentrations on the human intestinal flora’s colonization resistance (CR) to Salmonella kedougou NCTC 12173. Four steady state microbial communities were established in chemostats using inocula from a single pool of human feces. Three chemostats were exposed to CI (0.1, 0.43 and 5 μg/mL, respectively); one served as a no-drug control. The CR of each community was tested by three successive daily challenges of 108 S. kedougou, each delivered in a 1 mL bolus. There was no colonization of the no-drug chemostat. Likewise, after exposure to only 0.1 μg/mL CI there was no loss of CR and S. kedougou did not colonize. Conversely, both the 0.43 and the 5 μg/mL-exposed floras suffered a loss of CR and these chemostats were colonized. S. kedougou overgrew faster and reached higher counts in the presence of 0.43 than it did in the presence of 5 μg/mL. One possible explanation is that CI had a dose-dependent effect on both the challenge strain and CR. Thus, at higher levels, even though CR was disrupted by CI, so too was the growth of the challenge strain. Since exposure to CI elicited a dose-dependent reduction in Escherichia coli counts [Reg. Pharmacol. Toxicol. 33 (2001) 276] our new data suggest that E. coli may contribute to the CR against salmonella. We further conclude that, even at fecal levels below those reached during therapy, CI may impact the human gut flora sufficiently to facilitate colonization by S. kedougou. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Quinolone antibacterial agents
KW - Food contamination
KW - Salmonella
KW - Ciprofloxacin
KW - Antibiotic
KW - Antimicrobial
KW - Barrier effect
KW - Chemostat
KW - Competitive exclusion
KW - Feces
KW - Fluoroquinolone
KW - Intestinal
KW - Nurmi effect
KW - Residue
N1 - Accession Number: 15424464; Carman, Robert J. 1; Email Address: rjcarman@techlab.com; Simon, Mary Alice 1; Fernández, Haydée 2; Miller, Margaret A. 2; Bartholomew, Mary J. 2; Affiliations: 1: TechLab, Inc., 2001 Kraft Drive, Blacksburg, VA 24060-6358, United States; 2: United States Food and Drug Administration—Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, United States; Issue Info: Dec2004, Vol. 40 Issue 3, p319; Thesaurus Term: Quinolone antibacterial agents; Thesaurus Term: Food contamination; Thesaurus Term: Salmonella; Subject Term: Ciprofloxacin; Author-Supplied Keyword: Antibiotic; Author-Supplied Keyword: Antimicrobial; Author-Supplied Keyword: Barrier effect; Author-Supplied Keyword: Chemostat; Author-Supplied Keyword: Competitive exclusion; Author-Supplied Keyword: Feces; Author-Supplied Keyword: Fluoroquinolone; Author-Supplied Keyword: Intestinal; Author-Supplied Keyword: Nurmi effect; Author-Supplied Keyword: Residue; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.yrtph.2004.08.005
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ER -
TY - JOUR
AU - Dietz, Vance
AU - Venczel, Linda
AU - Izurieta, Héctor
AU - Stroh, George
AU - Zell, Elizabeth R.
AU - Monterroso, Edgar
AU - Tambini, Gina
T1 - Assessing and monitoring vaccination coverage levels: lessons from the Americas.
JO - Revista Panamericana de Salud Publica
JF - Revista Panamericana de Salud Publica
Y1 - 2004/12//
VL - 16
IS - 6
M3 - Article
SP - 432
EP - 442
SN - 10204989
AB - Examines the methods used by countries in the U.S. to assess vaccination information and coverage levels and assesses the methods recommended by the Pan American Health Organization (PAHO). Method used in examining the actual coverage level; Comparison of different methodologies to assess vaccination coverage levels; Objectives of PAHO; Factors needed in adopting coverage goals.
KW - VACCINATION
KW - VACCINES
KW - HEALTH
KW - ASSOCIATIONS, institutions, etc.
KW - UNITED States
KW - Americas
KW - health care evaluation mechanisms
KW - health surveys
KW - immunization programs
KW - mass immunization
KW - population surveillance
N1 - Accession Number: 15852241; Dietz, Vance 1; Email Address: vxd0@cdc.gov Venczel, Linda 1 Izurieta, Héctor 2 Stroh, George 3 Zell, Elizabeth R. 4 Monterroso, Edgar 5 Tambini, Gina 6; Affiliation: 1: Centers for Disease Control and Prevention, National Immunization Program, Global Immunization Division, Atlanta, Georgia, United States of America 2: United States Food and Drug Administration, Rockville, Maryland, United States of America 3: Private consultant, Donnelly, Idaho, United States of America 4: United States of America, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America 5: Centers for Disease Control and Prevention, Global AIDS Program, Guatemala City, Guatemala 6: Pan American Health Organization, Family and Community Health Area, Washington, D.C., United States of America; Source Info: Dec2004, Vol. 16 Issue 6, p432; Subject Term: VACCINATION; Subject Term: VACCINES; Subject Term: HEALTH; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: UNITED States; Author-Supplied Keyword: Americas; Author-Supplied Keyword: health care evaluation mechanisms; Author-Supplied Keyword: health surveys; Author-Supplied Keyword: immunization programs; Author-Supplied Keyword: mass immunization; Author-Supplied Keyword: population surveillance; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Illustrations: 3 Diagrams, 1 Chart; Document Type: Article
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ER -
TY - JOUR
AU - Williams, Richard A.
AU - Thompson, Kimberly M.
T1 - Integrated Analysis: Combining Risk and Economic Assessments While Preserving the Separation of Powers.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2004/12//
VL - 24
IS - 6
M3 - Article
SP - 1613
EP - 1623
PB - Wiley-Blackwell
SN - 02724332
AB - This article presents a process for an integrated policy analysis that combines risk assessment and benefit-cost analysis. This concept, which explicitly combines the two types of related analyses, seems to contradict the long-accepted risk analysis paradigm of separating risk assessment and risk management since benefit-cost analysis is generally considered to be a part of risk management. Yet that separation has become a problem because benefit-cost analysis uses risk assessment results as a starting point and considerable debate over the last several years focused on the incompatibility of the use of upper bounds or“safe” point estimates in many risk assessments with benefit-cost analysis. The problem with these risk assessments is that they ignore probabilistic information. As advanced probabilistic techniques for risk assessment emerge and economic analysts receive distributions of risks instead of point estimates, the artificial separation between risk analysts and the economic/decision analysts complicates the overall analysis. In addition, recent developments in countervailing risk theory suggest that combining the risk and benefit-cost analyses is required to fully understand the complexity of choices and tradeoffs faced by the decisionmaker. This article also argues that the separation of analysis and management is important, but that benefit-cost analysis has been wrongly classified into the risk management category and that the analytical effort associated with understanding the economic impacts of risk reduction actions need to be part of a broader risk assessment process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Cost analysis
KW - Risk management in business
KW - Policy analysis
KW - Benefit-cost analysis
KW - countervailing risk
KW - economic analysis
N1 - Accession Number: 15456649; Williams, Richard A. 1; Thompson, Kimberly M. 2; Email Address: kimt@hsph.harvard.edu; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740; 2: Harvard University, School of Public Health, Department of Health Policy and Management, 677 HuntingtonAvenue, Boston, MA 02115; Issue Info: Dec2004, Vol. 24 Issue 6, p1613; Thesaurus Term: Risk assessment; Thesaurus Term: Cost analysis; Subject Term: Risk management in business; Subject Term: Policy analysis; Author-Supplied Keyword: Benefit-cost analysis; Author-Supplied Keyword: countervailing risk; Author-Supplied Keyword: economic analysis; Number of Pages: 11p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1111/j.0272-4332.2004.00554.x
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DB - eih
ER -
TY - JOUR
AU - Gaylor, David W.
AU - Slikker Jr., William
T1 - Role of the Standard Deviation in the Estimation of Benchmark Doses with Continuous Data.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2004/12//
VL - 24
IS - 6
M3 - Article
SP - 1683
EP - 1687
PB - Wiley-Blackwell
SN - 02724332
AB - For continuous data, risk is defined here as the proportion of animals with values above a large percentile, e.g., the 99th percentile or below the 1st percentile, for the distribution of values among control animals. It is known that reducing the standard deviation of measurements through improved experimental techniques will result in less stringent (higher) doses for the lower confidence limit on the benchmark dose that is estimated to produce a specified risk of animals with abnormal levels for a biological effect. Thus, a somewhat larger (less stringent) lower confidence limit is obtained that may be used as a point of departure for low-dose risk assessment. It is shown in this article that it is important for the benchmark dose to be based primarily on the standard deviation among animals, sa, apart from the standard deviation of measurement errors, m, within animals. If the benchmark dose is incorrectly based on the overall standard deviation among average values for animals, which includes measurement error variation, the benchmark dose will be overestimated and the risk will be underestimated. The bias increases as sm increases relative to sa. The bias is relatively small if sm is less than one-third of sa, a condition achieved in most experimental designs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Animals
KW - Standard deviations
KW - Analysis of variance
KW - Measurement errors
KW - Analytical measurement variation
KW - benchmark dose
KW - confidence limits
KW - risk assessment
KW - standard deviation among animals
N1 - Accession Number: 15456644; Gaylor, David W. 1; Slikker Jr., William 2; Email Address: wslikker@nctr.fda.gov; Affiliations: 1: Gaylor and Associates, LLC, Little Rock, AR; 2: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR; Issue Info: Dec2004, Vol. 24 Issue 6, p1683; Thesaurus Term: Risk assessment; Thesaurus Term: Animals; Subject Term: Standard deviations; Subject Term: Analysis of variance; Subject Term: Measurement errors; Author-Supplied Keyword: Analytical measurement variation; Author-Supplied Keyword: benchmark dose; Author-Supplied Keyword: confidence limits; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: standard deviation among animals; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.0272-4332.2004.559_1.x
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ER -
TY - JOUR
AU - Lord, Alexandra M.
T1 - 'Naturally Clean and Wholesome': Women, Sex Education, and the United States Public Health Service, 1918-1928.
JO - Social History of Medicine
JF - Social History of Medicine
Y1 - 2004/12//
VL - 17
IS - 3
M3 - Article
SP - 423
EP - 441
SN - 0951631X
AB - In 1918, the US Public Health Service (PHS) launched a sex education campaign intended to educate Americans, young and old, male and female, on the perils of venereal disease (VD). As the "guardians of the community's health," women were central to this effort, and the PHS aggressively called on these newly enfranchised citizens to provide comprehensive sex education in their homes, schools, churches, and community settings. But even as the PHS called on women to spearhead local and community efforts against VD, it used highly stereotyped images to endorse and advocate passive images of women and female sexuality. An analysis of this campaign and its failure provides insight into the ways in which the federal government attempted to use the forum of public health both to reshape the family and to transform existing patterns of sexual behavior during the 1920's. The failure of these attempts also provides a new understanding into the question of why federally funded sex education programs have generally been unsuccessful in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social History of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX education
KW - PUBLIC health
KW - WOMEN
KW - HUMAN sexuality -- Psychological aspects
KW - HUMAN sexuality
KW - STEREOTYPES (Social psychology)
KW - SEXUALLY transmitted diseases
KW - UNITED States
KW - adolescence
KW - female sexuality
KW - gender
KW - progressivism
KW - prostitution
KW - public health
KW - sex education
KW - the General Federation of Women's Clubs
KW - the United States Public Health Service
KW - venereal disease
KW - UNITED States. Public Health Service
N1 - Accession Number: 15650024; Lord, Alexandra M. 1; Email Address: alord@psc.gov; Affiliations: 1 : Acting Historian, United States Public Health Service, Office of the Public Health Service Historian, Parklawn Building, Room 695, 5600 Fishers Lane, Rockville MD 20857, USA; Source Info: Dec2004, Vol. 17 Issue 3, p423; Note: Copyright© 2004 Society for the Social History of Medicine. All rights reserved. Reprinted by permission of Oxford University Press.; Historical Period: 1918 to 1928; Subject Term: SEX education; Subject Term: PUBLIC health; Subject Term: WOMEN; Subject Term: HUMAN sexuality -- Psychological aspects; Subject Term: HUMAN sexuality; Subject Term: STEREOTYPES (Social psychology); Subject Term: SEXUALLY transmitted diseases; Subject: UNITED States; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: female sexuality; Author-Supplied Keyword: gender; Author-Supplied Keyword: progressivism; Author-Supplied Keyword: prostitution; Author-Supplied Keyword: public health; Author-Supplied Keyword: sex education; Author-Supplied Keyword: the General Federation of Women's Clubs; Author-Supplied Keyword: the United States Public Health Service; Author-Supplied Keyword: venereal disease; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Germolec, D. R.
AU - Kashon, M.
AU - Nyska, A.
AU - Kuper, C. F.
AU - Portier, C.
AU - Kommineni, C.
AU - Johnson, K. A.
AU - Luster, M. I.
T1 - The Accuracy of Extended Histopathology to Detect Immunotoxic Chemicals.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/12//
VL - 82
IS - 2
M3 - Article
SP - 504
EP - 514
PB - Oxford University Press / USA
SN - 10966080
AB - The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies, in which previously detailed immunotoxicity assessment was performed. In addition, a positive control data set of three known immunosuppressive agents, one negative control data set, and an additional negative control group composed of the vehicle only treated groups were included. Data obtained from extended histopathology evaluations were compared to more traditional immune test results (both functional and nonfunctional) from previously conducted immunotoxicity assessments. Analyses of the data indicated that the ability to identify immunotoxic chemicals using histological endpoints decreased linearly as the level of stringency used to determine significant histopathological changes increased. A relatively high (80%) accuracy level was achieved when histological changes were considered in toto (i.e., any histological abnormality in the three tissues examined), using minimal or mild criteria for scoring. When minimal or mild histological changes were considered significant for a specific tissue, a 60% level of accuracy in identifying immunotoxic chemicals was obtained as compared to a 90% accuracy level that was achieved with this data set using the antibody plaque forming cell response, considered to represent the most predictive functional test. A minimal classification was obtained in the analyses of the negative control groups, suggesting that use of the minimal classification for hazard identification is inappropriate as it will likely result in a high incidence of false positives. This was not the case when mild classifications were used as an indicator of significance, which in most instances allowed the successful identification of negatives. When moderate to marked histopathological changes were used to identify immunotoxic chemicals, the level of accuracy that could be achieved was poor. A considerably higher level of accuracy was obtained for the positive control data set than the test chemical data set suggesting that the ability to detect an immunotoxic agent histologically is proportional to the potency of the immunotoxic agent. Comparison of immune function test results and histopathological results obtained from the high-dose treatment groups and the lower-dose treatment group did not reveal any significant differences between the two endpoints to predict immunotoxicity as a function of dose. Of the three lymphoid organs examined, (i.e., lymph node, thymus, and spleen), the most consistent and discernible histological lesions were observed in the thymus cortical region. These lesions correlated with thymus: body weight ratios and to a slightly lesser extent, the antibody plaque forming cell response. Addition of general toxicological endpoints such as body weight and leukocyte counts did not significantly improve the sensitivity of extended histopathology for this data set. Taken together, these data suggest that, while not as sensitive as functional analyses, extended histopathology may provide a reasonable level of accuracy as a screening test to identify immunotoxic chemicals, provided the level of stringency used to score histological lesions is carefully considered to allow for detection of immunotoxic agents while limiting false positives. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathological histology
KW - Immunotoxicology
KW - Lymphoid tissue
KW - Immunosuppressive agents
KW - Functional analysis
KW - B6C3F1 mice
KW - extended histopathology
KW - immunotoxicity
KW - safety assessment
KW - screening tests
KW - National Toxicology Program (U.S.)
N1 - Accession Number: 20606062; Germolec, D. R. 1; Email Address: germolec@niehs.nih.gov; Kashon, M. 2; Nyska, A. 3; Kuper, C. F. 4; Portier, C. 5; Kommineni, C. 6; Johnson, K. A. 7; Luster, M. I. 8; Affiliations: 1: Laboratory of Molecular Toxicology/National Toxicology Program, National Institute of Environmental Health Sciences, RTP, North Carolina; 2: Biostatistics Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 3: Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, RTP, North Carolina; 4: TNO Nutrition and Food Research, Zeist, The Netherlands; 5: Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, RTP, North Carolina; 6: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 7: Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan; 8: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Dec2004, Vol. 82 Issue 2, p504; Subject Term: Pathological histology; Subject Term: Immunotoxicology; Subject Term: Lymphoid tissue; Subject Term: Immunosuppressive agents; Subject Term: Functional analysis; Author-Supplied Keyword: B6C3F1 mice; Author-Supplied Keyword: extended histopathology; Author-Supplied Keyword: immunotoxicity; Author-Supplied Keyword: safety assessment; Author-Supplied Keyword: screening tests ; Company/Entity: National Toxicology Program (U.S.); Number of Pages: 11p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfh271
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scallet, A. C.
AU - Divine, R. L.
AU - Newbold, R. R.
AU - Delclos, K. B.
T1 - Increased Volume of the Calbindin D28k-Labeled Sexually Dimorphic Hypothalamus in Genistein and Nonylphenol-Treated Male Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2004/12//
VL - 82
IS - 2
M3 - Article
SP - 570
EP - 576
PB - Oxford University Press / USA
SN - 10966080
AB - The adult rat brain develops through an interplay of neuronal proliferation and programmed cell death. Steroid hormones and growth factors may alter the balance between these competing processes. “Endocrine disrupters” (EDs) may also alter brain development, by mimicry or modulation of endogenous hormone systems. Under control conditions, the sexually dimorphic nucleus (SDN) of the medial preoptic hypothalamus becomes larger in adult males than females, but its final volume may also reflect the hormonal conditions prevailing during development. Two EDs that have recently been studied in protocols involving lifespan exposures are the phytoestrogen genistein and the weakly estrogenic compound para-nonylphenol, which is used in the production of many surfactants and plastics. Experimental dietary exposure of adult female rats to genistein or p-nonylphenol began 28 days prior to their mating at concentrations of 5 ppm, 100 ppm, and 500 ppm for genistein or 25 ppm, 200 ppm, and 750 ppm for p-nonylphenol. Exposure of the offspring continued throughout gestation and lactation, as well as in their chow after weaning, until they were sacrificed at 140 days of age for immunohistochemical labeling of the calbindin D28k-labeled subdivision of the SDN: the CALB-SDN. Both genistein and nonylphenol were found to increase the volume of the CALB-SDN in male rats (p's < 0.01), but not in female rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cell death
KW - Endocrine disruptors
KW - PHYSIOLOGY
KW - Rats
KW - Steroid hormones
KW - Growth factors
KW - Hypothalamic hormones
KW - Hypothalamus
KW - 3-D reconstruction
KW - calcium binding proteins
KW - endocrine disrupters
KW - estrogens
KW - hypothalamus
KW - medial preoptic nucleus
KW - sex differences
N1 - Accession Number: 20606085; Scallet, A. C. 1; Email Address: ascallet@nctr.fda.gov; Divine, R. L. 2; Newbold, R. R. 3; Delclos, K. B. 4; Affiliations: 1: Division of Neurotoxicology National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079; 2: Charles River Laboratories, Jefferson, Arkansas 72079; 3: Environmental Toxicology Program, National Institute for Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709; 4: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079; Issue Info: Dec2004, Vol. 82 Issue 2, p570; Thesaurus Term: Cell death; Thesaurus Term: Endocrine disruptors; Thesaurus Term: PHYSIOLOGY; Subject Term: Rats; Subject Term: Steroid hormones; Subject Term: Growth factors; Subject Term: Hypothalamic hormones; Subject Term: Hypothalamus; Author-Supplied Keyword: 3-D reconstruction; Author-Supplied Keyword: calcium binding proteins; Author-Supplied Keyword: endocrine disrupters; Author-Supplied Keyword: estrogens; Author-Supplied Keyword: hypothalamus; Author-Supplied Keyword: medial preoptic nucleus; Author-Supplied Keyword: sex differences; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfh297
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Derlet, Robert W.
AU - Carlson, James R.
AU - Noponen, Mikla N.
T1 - Coliform and Pathologic Bacteria in Sierra Nevada National Forest Wilderness Area Lakes and Streams.
JO - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
JF - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
Y1 - 2004///Winter2004
VL - 15
IS - 4
M3 - Article
SP - 245
EP - 249
PB - Allen Press Publishing Services Inc.
SN - 10806032
AB - Objective.--To analyze backcountry-area water quality in US Department of Agriculture Forest Service-designated wilderness areas for the presence of coliform and potentially pathogenic bacteria. Methods.--Thirty-one backcountry lakes and streams were selected that would stratify the risk based on use by backpackers, pack animals, commercial grazing animals, or natural unaffected wilderness areas. Sites included Desolation Wilderness (10 sites), Carson-Iceberg Wilderness (4 sites), Emigrant Wilderness (3 sites), Hoover Wilderness (6 sites), John Muir Wilderness (3 sites), and Golden Trout Wilderness (5 sites). Water was collected in sterile tubes and quantification was performed through Millipore bacterial samplers. On return to the laboratory, bacteria were harvested from the samplers and subjected to qualitative analysis that identified species according to standard laboratory methods. Results.--Coliform bacteria were detected in 14 of 31 sites (45%). Eight sites had high levels of coliforms. All 8 of these sites correlated with heavy human use or commercial grazing. Coliforms were identified as Escherichia coli. In addition, 1 sample contained Yersinia entercolitica. All samples contained expected amounts of normal aquatic bacteria, including Pseudomonas spp, Rahnella aquatilis, Serratia spp, and other nonpathogenic species of Yersinia in concentrations of 600 to 10 000 colony-forming units per 100 mL. Conclusions.--In this study, coliform bacteria were found at nearly half of the sampling sites. High coliform levels correlated with high-impact human use or cattle grazing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.) is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic bacteria
KW - Wilderness areas
KW - Bacteria
KW - Hoover Wilderness (Calif.)
KW - California
KW - coliforms
KW - Escherichia coli
KW - Sierra Nevada
KW - wilderness bacteria
KW - wilderness water
KW - United States. Dept. of Agriculture
N1 - Accession Number: 15418058; Derlet, Robert W. 1; Email Address: rwderlet@ucdavis.edu; Carlson, James R. 2; Noponen, Mikla N. 3; Affiliations: 1: Departments of Internal Medicine, University of California, Davis, School of Medicine, Sacramento, CA; 2: Departments of Pathology, and Medical Microbiology Lab University of California, Davis, School of Medicine, Sacramento, CA; 3: US Indian Health Service, Tuolumne County, CA; Issue Info: Winter2004, Vol. 15 Issue 4, p245; Thesaurus Term: Pathogenic bacteria; Thesaurus Term: Wilderness areas; Thesaurus Term: Bacteria; Subject: Hoover Wilderness (Calif.); Subject: California; Author-Supplied Keyword: coliforms; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Sierra Nevada; Author-Supplied Keyword: wilderness bacteria; Author-Supplied Keyword: wilderness water ; Company/Entity: United States. Dept. of Agriculture; NAICS/Industry Codes: 712190 Nature Parks and Other Similar Institutions; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2004-11446-016
AN - 2004-11446-016
AU - Petrikis, P.
AU - Andreou, C.
AU - Pitsavas, A.
AU - Garyfallos, G.
T1 - Late-Onset Obsessive-Compulsive Disorder Without Evidence of Focal Cerebral Lesions: A Case Report.
JF - The Journal of Neuropsychiatry and Clinical Neurosciences
JO - The Journal of Neuropsychiatry and Clinical Neurosciences
Y1 - 2004///Win 2004
VL - 16
IS - 1
SP - 116
EP - 117
CY - US
PB - American Psychiatric Assn
SN - 0895-0172
SN - 1545-7222
N1 - Accession Number: 2004-11446-016. PMID: 14990768 Partial author list: First Author & Affiliation: Petrikis, P.; Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece. Release Date: 20040726. Correction Date: 20090727. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Conference Information: 16th Hellenic Congress of Psychiatry, Apr, 2002, Chalkidiki, Greece. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Drug Therapy; Obsessive Compulsive Disorder; Onset (Disorders); Paroxetine. Classification: Neuroses & Anxiety Disorders (3215). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Clinical Case Study; Empirical Study. References Available: Y. Page Count: 2. Issue Publication Date: Win 2004.
AB - This article presents a case-report describing the rare case of a patient with late-onset obsessive-compulsive disorder (OCD) without any specific underlying cerebral lesions. Mr. L., a 68-year-old married white man, presented himself at the Center of Mental Health Services with OCD symptoms that had appeared two years before. His symptoms consisted of excessive worries of infection. Head scans with computed tomography (CT) and magnetic resonance imaging (MRI) did not reveal any abnormalities. Mr. L. was started on a treatment with paroxetine, whose dose was gradually raised to 40 mg/day. His symptoms resolved after 3 weeks of treatment. Ten months later, Mr. L. continues his treatment and remains asymptomatic. The uniqueness of the presented case consists in the fact that it concerns a late-onset, after the age of 65, occurrence of OCD in a man; moreover, no signs of underlying cerebral pathology could be detected, as it usually is the case in late-onset OCD. Our patient's response to medication was excellent, something rather unusual in the 'late' forms of OCD. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - late-onset obsessive-compulsive disorder
KW - focal cerebral lesions
KW - cerebral pathology
KW - paroxetine
KW - drug therapy
KW - 2004
KW - Drug Therapy
KW - Obsessive Compulsive Disorder
KW - Onset (Disorders)
KW - Paroxetine
KW - 2004
DO - 10.1176/appi.neuropsych.16.1.116
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06984-002
AN - 2005-06984-002
AU - Koontz, Ann M.
AU - Buckley, Kathleen A.
AU - Ruderman, Marjory
T1 - The Evolution of Fetal and Infant Mortality Review as a Public Health Strategy.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2004/12//
VL - 8
IS - 4
SP - 195
EP - 203
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Koontz, Ann M., Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-12, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06984-002. PMID: 15623142 Partial author list: First Author & Affiliation: Koontz, Ann M.; Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20051024. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Fetus; Health Promotion; Infant Development; Mortality Rate; Health Care Policy. Minor Descriptor: Public Health. Classification: Community & Social Services (3373). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2004.
AB - Infant mortality review (IMR), the forerunner of fetal and infant mortality review (FIMR), emerged at the national level in the mid-1980s as a promising method to improve understanding of local factors contributing to infant mortality and to motivate community response. Building on federal efforts to enhance data capacity and early state and local infant mortality case review studies, the federal Maternal and Child Health Bureau (MCHB) initiated its IMR Program in 1988. Key actions taken to refine and diffuse the IMR/FIMR method include forging a public-private partnership between MCHB and the American College of Obstetricians and Gynecologists in 1990 to develop the National Fetal and Infant Mortality Review Program, recruiting prominent leaders to advocate for FIMR, seeding community projects in geographically dispersed states and localities, and routinely reporting best practices information to the field. In concert with the articulation of core public health functions and a growing emphasis on accountability, attention at the national level has turned to promoting and institutionalizing FIMR in state systems. Efforts are underway in states to build on the FIMR model and coordinate multiple maternal and child health-related review programs. Increasingly, FIMR is recognized as a strategy for contributing to implementation of the core public health functions of assessment, policy development, and quality assurance. The recent national evaluation of FIMR sheds new light on the role of FIMR in community and state maternal and child health systems and marks a new phase in the evolution of FIMR. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal mortality
KW - infant mortality review
KW - public health strategy
KW - health care programs
KW - health promotion
KW - 2004
KW - Fetus
KW - Health Promotion
KW - Infant Development
KW - Mortality Rate
KW - Health Care Policy
KW - Public Health
KW - 2004
DO - 10.1023/B:MACI.0000047418.14086.fc
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UR - akoontz@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20067-004
AN - 2004-20067-004
AU - Henry, Alexis D.
AU - Lucca, Anna M.
AU - Banks, Steven
AU - Simon, Lorna
AU - Page, Stephanie
T1 - Inpatient Hospitalizations and Emergency Service Visits among Participants in an Individual Placement and Support (IPS) Model Program.
JF - Mental Health Services Research
JO - Mental Health Services Research
JA - Ment Health Serv Res
Y1 - 2004/12//
VL - 6
IS - 4
SP - 227
EP - 237
CY - Germany
PB - Springer
SN - 1522-3434
SN - 1573-6636
AD - Henry, Alexis D., Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US
N1 - Accession Number: 2004-20067-004. PMID: 15588033 Partial author list: First Author & Affiliation: Henry, Alexis D.; Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, US. Release Date: 20041129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emergency Services; Hospitalization; Program Evaluation; Supported Employment. Minor Descriptor: Mental Disorders. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Tests & Measures: Global Assessment of Function Scale. Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2004.
AB - Supported employment (SE) is considered an 'evidence-based' practice for people with serious mental illness. We examined inpatient hospitalizations and emergency service visits among clients in a SE program based on the Individual Placement and Support (IPS) model in comparison to a propensity score matched group of clients who did not participate in IPS. A significant interaction showed that only IPS/SE clients who were also high in regular mental health services had fewer hospitalizations and emergency service visits than matched controls. The interaction effect was moderate, even when we controlled for client functioning. These findings provide support for the integration of mental health and vocational rehabilitation services, a key feature of evidence-based SE services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - inpatient hospitalizations
KW - emergency service visits
KW - supported employment program
KW - Individual Placement and Support model
KW - mental illness
KW - 2004
KW - Emergency Services
KW - Hospitalization
KW - Program Evaluation
KW - Supported Employment
KW - Mental Disorders
KW - 2004
DO - 10.1023/B:MHSR.0000044748.24924.a0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20067-004&site=ehost-live&scope=site
UR - alexis.henry@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06984-008
AN - 2005-06984-008
AU - Hutchins, Ellen
AU - Grason, Holly
AU - Handler, Arden
T1 - FIMR and Other Mortality Reviews as Public Health Tools for Strengthening Maternal and Child Health Systems in Communities: Where do We Need to go Next?
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2004/12//
VL - 8
IS - 4
SP - 259
EP - 268
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Hutchins, Ellen, Perinatal and Women's Health Branch, Maternal and Child Health Bureau, Parklawn Building, Room 18-12, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06984-008. PMID: 15623148 Partial author list: First Author & Affiliation: Hutchins, Ellen; Department of Health and Human Services, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20051024. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Services; Fetus; Infant Development; Mortality Rate; Public Health Services. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2004.
AB - This article examines FIMR in relationship to two other maternal and child health mortality reviews--child fatality review (CFR) and maternal mortality review (MMR), and explores how their approaches to reviewing deaths can complement one another. Identifying opportunities for collaboration among these case review methodologies may lead to greater efficiencies at the local and state levels and strengthen the case review approach as a public health tool for improving maternal and child health outcomes. To enable comparative analysis, a table was constructed that identifies the purpose, structure, and process features of each case review approach. This was followed by an examination of two possible ways to improve maternal and child mortality review processes in states: 1) better coordination; and 2) improving each individual process through adapting and adopting promising practices from the others. A discussion is also provided of the state Title V role in facilitating both the coordination of reviews and the process of sharing best practices. Given the similarities that exist among the three MCH mortality reviews, it is important to view each review as one component of a larger system of maternal and child health death reviews. Implementing widely the recommendations generated by these reviews may increase the likelihood of improvements in services and systems on behalf of women and children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal infant mortality review
KW - public health tools
KW - maternal health system
KW - child health system
KW - child care services
KW - 2004
KW - Community Services
KW - Fetus
KW - Infant Development
KW - Mortality Rate
KW - Public Health Services
KW - 2004
DO - 10.1023/B:MACI.0000047424.62781.0d
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06984-008&site=ehost-live&scope=site
UR - ehutchins@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07156-005
AN - 2005-07156-005
AU - Higgins, Doloris N.
AU - Tierney, Jeanette
AU - Lins, Meredith
AU - Hanrahan, Lawrence
T1 - School Nurses: A Resource for Young Worker Safety.
JF - The Journal of School Nursing
JO - The Journal of School Nursing
JA - J Sch Nurs
Y1 - 2004/12//
VL - 20
IS - 6
SP - 317
EP - 323
CY - US
PB - Alliance Communications Group
SN - 1059-8405
SN - 1546-8364
N1 - Accession Number: 2005-07156-005. PMID: 15560728 Partial author list: First Author & Affiliation: Higgins, Doloris N.; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Sage Publications. Release Date: 20060213. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Labor; Injuries; Occupational Safety; School Nurses. Minor Descriptor: Child Welfare; Death and Dying; Schools. Classification: Working Conditions & Industrial Safety (3670); Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2004.
AB - On average, 67 youths under age 18 die at work in the United States each year, and many more suffer work-related injuries. In 1998, an estimated 77,000 young workers suffered work injuries that required treatment in hospital emergency rooms. It is estimated that only one third of work-related injuries are seen in emergency departments; therefore, the National Institute for Occupational Safety and Health (NIOSH) estimates that nearly 230,000 youths suffer work-related injuries each year. Through NIOSH's Fatality Assessment and Control Evaluation (FACE) program, NIOSH investigators identified poor knowledge of child labor laws, lack of safety training and supervision, inappropriate job assignment, and lack of employer compliance with labor laws as factors contributing to young worker deaths. School nurses serve as a resource to other professionals, parents, employers, and students and can help foster safer working conditions for youth by providing these groups with young worker safety information. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - school nurses
KW - work related injuries
KW - youth labor
KW - occupational safety
KW - job assignment
KW - fatalities
KW - 2004
KW - Child Labor
KW - Injuries
KW - Occupational Safety
KW - School Nurses
KW - Child Welfare
KW - Death and Dying
KW - Schools
KW - 2004
DO - 10.1177/10598405040200060501
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07156-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20142-005
AN - 2004-20142-005
AU - Rivera, Edil Torres
AU - Wilbur, Michael
AU - Roberts-Wilbur, Janice
AU - Phan, Loan T.
AU - Garrett, Michael T.
AU - Betz, Robert L.
T1 - Supervising and Training Psychoeducational Group Leaders.
JF - Journal for Specialists in Group Work
JO - Journal for Specialists in Group Work
Y1 - 2004/12//
VL - 29
IS - 4
SP - 377
EP - 394
CY - United Kingdom
PB - Taylor & Francis
SN - 0193-3922
SN - 1549-6295
AD - Rivera, Edil Torres, Counseling, School, and Educational Psychology Department, University at Buffalo, SUNY, 409 Baldy Hall, Buffalo, NY, US, 14260
N1 - Accession Number: 2004-20142-005. Partial author list: First Author & Affiliation: Rivera, Edil Torres; Counseling, School, and Educational Psychology Department, University at Buffalo, SUNY, Buffalo, NY, US. Release Date: 20041129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counselor Education; Group Counseling; Professional Supervision; Psychoeducation. Classification: Professional Education & Training (3410). Population: Human (10). References Available: Y. Page Count: 18. Issue Publication Date: Dec, 2004.
AB - This article provides a description of the structure and examples of how the socio-process group may be used as a major approach for the training and supervision of psychoeducational groups. The distinguishing characteristics of this psychoeducational group approach are provided, along with examples, strategies, and guidelines for its application to the training and supervision of group leaders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychoeducational group
KW - training
KW - group leaders
KW - supervising
KW - 2004
KW - Counselor Education
KW - Group Counseling
KW - Professional Supervision
KW - Psychoeducation
KW - 2004
DO - 10.1080/01933920490516134
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20142-005&site=ehost-live&scope=site
UR - etrivera@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20136-008
AN - 2004-20136-008
AU - Nguyen, Ly
AU - Arganza, Girlyn F.
AU - Huang, Larke N.
AU - Liao, Qinghong
AU - Nguyen, Hoang T.
AU - Santiago, Rolando
T1 - Psychiatric diagnoses and clinical characteristics of Asian American youth in children's services.
JF - Journal of Child and Family Studies
JO - Journal of Child and Family Studies
JA - J Child Fam Stud
Y1 - 2004/12//
VL - 13
IS - 4
SP - 483
EP - 495
CY - Germany
PB - Springer
SN - 1062-1024
SN - 1573-2843
AD - Nguyen, Ly, 803 Bonifant Street, Silver Spring, MD, US, 20910
N1 - Accession Number: 2004-20136-008. Partial author list: First Author & Affiliation: Nguyen, Ly; Center for Urban Health Research, Morgan State University, Baltimore, MD, US. Release Date: 20041129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Asians; Child Welfare; Mental Health Services; Psychiatric Symptoms; Psychodiagnosis. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Child and Adolescent Functional Assessment Scale; Child Behavior Checklist. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Dec, 2004.
AB - This study examined the psychiatric diagnoses and clinical characteristics of the 981 Asian American children enrolled in the first phase of the Comprehensive Community Mental Health Services for Children and Their Families Program. Asian Americans were less likely than non-Asian Americans to receive diagnoses of depression and ADHD and more likely to receive diagnoses of anxiety and adjustment disorder. As compared to non-Asians, Asian Americans were significantly more likely to be rated with severe functional impairment in community role performance, self-harmful behavior, and thinking. There was also a trend for fewer externalizing behavior problems. Implications for research and practice are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric diagnoses
KW - clinical characteristics
KW - Asian American youth
KW - children's services
KW - 2004
KW - Asians
KW - Child Welfare
KW - Mental Health Services
KW - Psychiatric Symptoms
KW - Psychodiagnosis
KW - 2004
DO - 10.1023/B:JCFS.0000044729.93879.c2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20136-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21562-008
AN - 2004-21562-008
AU - Murray-Johnson, Lisa
AU - Witte, Kim
AU - Patel, Dhaval
AU - Orrego, Victoria
AU - Zuckerman, Cynthia
AU - Maxfield, Andrew M.
AU - Thimons, Edward D.
T1 - Using the Extended Parallel Process Model to Prevent Noise-Induced Hearing Loss Among Coal Miners in Appalachia.
JF - Health Education & Behavior
JO - Health Education & Behavior
JA - Health Educ Behav
Y1 - 2004/12//
VL - 31
IS - 6
SP - 741
EP - 755
CY - US
PB - Sage Publications
SN - 1090-1981
SN - 1552-6127
AD - Murray-Johnson, Lisa, School of Journalism and Communication, Ohio State University, 3016 Derby Hall, 154N. Oval Mall, Columbus, OH, US, 43210
N1 - Accession Number: 2004-21562-008. PMID: 15539545 Other Journal Title: Health Education Monographs; Health Education Quarterly. Partial author list: First Author & Affiliation: Murray-Johnson, Lisa; School of Journalism and Communication, Ohio State University, Columbus, OH, US. Release Date: 20050207. Correction Date: 20110725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hearing Disorders; Injuries; Noise Effects; Occupational Safety; Risk Factors. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 2004.
AB - Occupational noise-induced hearing loss is the second most self-reported occupational illness or injury in the United States. Among coal miners, more than 90% of the population reports a hearing deficit by age 55. In this formative evaluation, focus groups were conducted with coal miners in Appalachia to ascertain whether miners perceive hearing loss as a major health risk and if so, what would motivate the consistent wearing of hearing protection devices (HPDs). The theoretical framework of the Extended Parallel Process Model was used to identify the miners' knowledge, attitudes, beliefs, and current behaviors regarding hearing protection. Focus group participants had strong perceived severity and varying levels of perceived susceptibility to hearing loss. Various barriers significantly reduced the self-efficacy and the response efficacy of using hearing protection. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - noise-induced hearing loss
KW - occupational injury
KW - health risk
KW - coal miners
KW - 2004
KW - Hearing Disorders
KW - Injuries
KW - Noise Effects
KW - Occupational Safety
KW - Risk Factors
KW - 2004
DO - 10.1177/1090198104263396
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21562-008&site=ehost-live&scope=site
UR - murray-johnson.1@osu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-21450-035
AN - 2004-21450-035
AU - Davis, Maryann
T1 - Review of You Remind Me of Me.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2004/12//
VL - 55
IS - 12
SP - 1454
EP - 1454
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2004-21450-035. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20041213. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Literature. Minor Descriptor: Drug Abuse; Emotional Trauma; Family Relations; Major Depression; Self-Concept. Classification: Literature & Fine Arts (2610). Population: Human (10). Reviewed Item: Chaon, Dan. You Remind Me of Me=New York, Ballantine Publications, 2004, 368 pages, $24.95; 2004. Page Count: 1. Issue Publication Date: Dec, 2004.
AB - In this article, I review 'You Remind Me of Me' by Dan Chaon. This is a novel about the meaning and impact of family, and about becoming an adult. In its exploration of both of these ideas, it is also a striking portrait of inner life juxtaposed with others' interpretations of behavior. It is a gentle novel that has great compassion for people struggling with their circumstances and choices. Most of the characters are clearly troubled and searching for ways to deal with emotional pain. Depression and substance abuse flow throughout the novel. Struggles to understand what it means to be a mother, a father, a brother, or a grandparent, the complexities of these relationships, and the issues raised by adoption permeate the pages. The inner ruminations are real and burning. Although readers will likely feel empathy for each of these characters, they will also understand why others react to them as they do. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - novel
KW - family
KW - behavior
KW - choices
KW - emotional pain
KW - depression
KW - substance abuse
KW - 2004
KW - Literature
KW - Drug Abuse
KW - Emotional Trauma
KW - Family Relations
KW - Major Depression
KW - Self-Concept
KW - 2004
U2 - Chaon, Dan. (2004); You Remind Me of Me; New York, Ballantine Publications, 2004, 368 pages, $24.95
DO - 10.1176/appi.ps.55.12.1454
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-21450-035&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-22438-004
AN - 2004-22438-004
AU - Razzaghi, Mehdi
AU - Kodell, Ralph
T1 - Quantitative Risk Assessment for Developmental Neurotoxic Effects.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2004/12//
VL - 24
IS - 6
SP - 1673
EP - 1681
CY - United Kingdom
PB - Blackwell Publishing
SN - 0272-4332
SN - 1539-6924
AD - Razzaghi, Mehdi, Bloomsburg University, Bloomsburg, PA, US, 17815
N1 - Accession Number: 2004-22438-004. PMID: 15660620 Partial author list: First Author & Affiliation: Razzaghi, Mehdi; Bloomsburg University, Bloomsburg, PA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain Damage; Neural Development; Neurotoxicity; Neurotoxins; Risk Assessment. Minor Descriptor: Brain Development; Decision Making; Fetus; Mathematical Modeling; Prenatal Exposure. Classification: Neurological Disorders & Brain Damage (3297); Animal Experimental & Comparative Psychology (2400). Population: Human (10); Animal (20). References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2004.
AB - Developmental neurotoxicity concerns the adverse health effects of exogenous agents acting on neurodevelopment. Because human brain development is a delicate process involving many cellular events, the developing fetus is rather susceptible to compounds that can alter the structure and function of the brain. Today, there is clear evidence that early exposure to many neurotoxicants can severely damage the developing nervous system. Although in recent years, there has been much attention given to model development and risk assessment procedures for developmental toxicants, the area of developmental neurotoxicity has been largely ignored. Here, we consider the problem of risk estimation for developmental neurotoxicants from animal bioassay data. Since most responses from developmental neurotoxicity experiments are nonquantal in nature, an adverse health effect will be defined as a response that occurs with very small probability in unexposed animals. Using a two-stage hierarchical normal dose-response model, upper confidence limits on the excess risk due to a given level of added exposure are derived. Equivalently, the model is used to obtain lower confidence limits on dose for a small negligible level of risk. Our method is based on the asymptotic distribution of the likelihood ratio statistic (cf. Crump, 1995). An example is used to provide further illustration. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developmental neurotoxicity
KW - adverse health effects
KW - exogenous agents
KW - neurodevelopment
KW - brain development
KW - neurotoxicants
KW - neurotoxins
KW - nervous system damage
KW - mathematical modeling
KW - 2004
KW - Brain Damage
KW - Neural Development
KW - Neurotoxicity
KW - Neurotoxins
KW - Risk Assessment
KW - Brain Development
KW - Decision Making
KW - Fetus
KW - Mathematical Modeling
KW - Prenatal Exposure
KW - 2004
DO - 10.1111/j.0272-4332.2004.00558.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-22438-004&site=ehost-live&scope=site
UR - razzaghi@bloomu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2004-20474-016
AN - 2004-20474-016
AU - Lin, Chung-Tung Jordan
AU - Lee, Jonq-Ying
AU - Yen, Steven T.
T1 - Do dietary intakes affect search for nutrient information on food labels?
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2004/12//
VL - 59
IS - 9
SP - 1955
EP - 1967
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Yen, Steven T., Department of Agricultural Economics, University of Tennessee, 308D Morgan Hall, Knoxville, TN, US, 37996-4518
N1 - Accession Number: 2004-20474-016. PMID: 15312929 Partial author list: First Author & Affiliation: Lin, Chung-Tung Jordan; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, US. Release Date: 20050307. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brand Preferences; Dietary Supplements; Food; Health Education; Nutrition. Minor Descriptor: Diets; Public Health. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Dec, 2004.
AB - Nutrition labels on food packages are designed to promote and protect public health by providing nutrition information so that consumers can make informed dietary choices. High levels of total fat, saturated fat and cholesterol in diets are linked to increased blood cholesterol levels and a greater risk of heart disease. Therefore, an understanding of consumer use of total fat, saturated fat, and cholesterol information on food labels has important implications for public health and nutrition education. This study explores the association between dietary intakes of these three nutrients and psychological or demographic factors and the search for total fat, saturated fat. and cholesterol information on food labels. Psychology literature suggests a negative association between intakes of these nutrients and probability of search for their information on food labels. Health behavior theories also suggest perceived benefits and costs of using labels and perceived capability of using labels are associated with the search behavior. We estimate the relationship between label information search and its predictors using logistic regressions. Our samples came from the 1994-1996 Continuing Survey of Food Intakes by Individuals and Diet and Health Knowledge Survey conducted by the United States Department of Agriculture. Results suggest that search for total fat, saturated fat, and cholesterol information on food labels is less likely among individuals who consume more of the three nutrients, respectively. The search is also related to perceived benefits and costs of using the label, perceived capability of using the label, knowledge of nutrition and fats, perceived efficacy of diets in reducing the risk of illnesses, perceived importance of nutrition in food shopping, perceived importance of a healthy diet, and awareness of linkage between excessive consumption of the nutrients and health problems. These findings suggest encouraging search of food label information among consumers with unhealthy dietary habits would need innovative approaches. Yet, nutrition education can be instrumental in encouraging this search by stimulating motivation and providing technical help. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dietary intake
KW - nutrient information
KW - food labels
KW - health education
KW - public health
KW - consumer preferences
KW - 2004
KW - Brand Preferences
KW - Dietary Supplements
KW - Food
KW - Health Education
KW - Nutrition
KW - Diets
KW - Public Health
KW - 2004
DO - 10.1016/j.socscimed.2004.02.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2004-20474-016&site=ehost-live&scope=site
UR - syen@utk.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2015-58146-005
AN - 2015-58146-005
AU - Riegel, Arthur C.
AU - Lupica, Carl R.
T1 - Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2004/12//
VL - 24
IS - 49
SP - 11070
EP - 11078
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Lupica, Carl R., Cellular Neurobiology Branch, Electrophysiology Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, MD, US, 21224
N1 - Accession Number: 2015-58146-005. PMID: 15590923 Partial author list: First Author & Affiliation: Riegel, Arthur C.; Cellular Neurobiology Branch, Electrophysiology Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Baltimore, MD, US. Release Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Gamma Aminobutyric Acid; Glutamate Receptors; Synapses. Minor Descriptor: Drug Abuse; Tegmentum. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2004. Publication History: Accepted Date: Nov 2, 2004; Revised Date: Oct 7, 2004; First Submitted Date: Jul 23, 2004. Copyright Statement: Society for Neuroscience. 2004.
AB - Dopamine (DA) neurons in the ventral tegmental area have been implicated in psychiatric disorders and drug abuse. Understanding the mechanisms through which their activity is regulated via the modulation of afferent input is imperative to understanding their roles in these conditions. Here we demonstrate that endocannabinoids liberated from DA neurons activate cannabinoid CB1 receptors located on glutamatergic axons and on GABAergic terminals targeting GABAB receptors located on these cells. Endocannabinoid release was initiated by inhibiting either presynaptic type-III metabotropic glutamate receptors or postsynaptic calcium-activated potassium channels, two conditions that also promote enhanced DA neuron excitability and bursting. Thus, activity-dependent release of endocannabinoids may act as a regulatory feedback mechanism to inhibit synaptic inputs in response to DA neuron bursting, thereby regulating firing patterns that may fine-tune DA release from afferent terminals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marijuana
KW - metabotropic glutamate receptors
KW - SK channels
KW - bursting
KW - mesolimbic
KW - GABA
KW - dopamine neuron
KW - GABA-B receptors
KW - 2004
KW - Dopamine
KW - Gamma Aminobutyric Acid
KW - Glutamate Receptors
KW - Synapses
KW - Drug Abuse
KW - Tegmentum
KW - 2004
U1 - Sponsor: National Institute on Drug Abuse, Intramural Research Program, US. Recipients: No recipient indicated
DO - 10.1523/JNEUROSCI.3695-04.2004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-58146-005&site=ehost-live&scope=site
UR - clupica@intra.nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Raiche, Joe
AU - Rodriguez-Juarez, Rocio
AU - Pogribny, Igor
AU - Kovalchuk, Olga
T1 - Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2004/12/03/
VL - 325
IS - 1
M3 - Article
SP - 39
EP - 47
SN - 0006291X
AB - DNA methylation is crucial for normal development, proliferation, and proper maintenance of genome stability for a given organism. A variety of DNA damaging agents that are known to affect genome stability were also shown to alter DNA methylation patterns. We have recently pioneered the studies in the area of the radiation effects on DNA methylation, and found that radiation exposure led to substantial dose-dependent and tissue-specific DNA hypomethylation, which was much more pronounced in spleen and liver of female animals. The exact mechanisms of radiation-induced DNA hypomethylation are still to be uncovered. We have previously shown that one of those mechanisms may potentially be DNA repair related. Another possible mechanism may be linked to changes in the expression of DNA methyltransferases (DNMTs). In the current study, we examined the radiation-induced changes in expression of maintenance DNMT1, and de novo methyltransferases DNMT3a and DNMT3b in spleen and liver of irradiated animals. This was paralleled by the studies of acute and chronic IR-induced methylation changes in spleen and liver of intact animals, as well as in animals with altered sex hormone status. Here we report that radiation-induced DNA methylation changes correlated with radiation-induced alterations in expression of DNA methyltransferases. We present the data on tissue-specificity in radiation-induced expression of DNA methyltransferases, and prove that changes in the expression of de novo methyltransferases DNMT3a and DNMT3b are the most important in radiation-induced DNA methylation alterations. We also discuss the role of sex hormones, especially estrogen, in the generation of the sex-specific radiation-induced methylation changes. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX hormones
KW - STEROID hormones
KW - LYMPHOID tissue
KW - GENETICS
KW - DNA methylation
KW - DNA methyltransferases
KW - Radiation
KW - Sex hormones
N1 - Accession Number: 14869294; Raiche, Joe 1 Rodriguez-Juarez, Rocio 1 Pogribny, Igor 2 Kovalchuk, Olga; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta., Canada T1K 3M4 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Dec2004, Vol. 325 Issue 1, p39; Subject Term: SEX hormones; Subject Term: STEROID hormones; Subject Term: LYMPHOID tissue; Subject Term: GENETICS; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: DNA methyltransferases; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: Sex hormones; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bbrc.2004.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14869294&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Struttmann, T. W.
T1 - Fatal and Nonfatal Occupational Injuries Involving Wood Chippers -- United States, 1992-2002.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/12/10/
VL - 53
IS - 48
M3 - Article
SP - 1130
EP - 1131
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Discusses a study conducted by the U.S. Centers for Disease Control and Prevention, which described fatal and nonfatal injuries related to occupational wood chippers based on the data from the U.S. Bureau of Labor Statistics Census of Fatal Occupational Injuries from 1992-2002. Total number of occupational injury deaths attributed to mobile chippers; Estimated number of injuries resulted from working with chippers; Factors to consider by employees to reduce their risk for injury of using wood chippers; Examples of personal protective equipment recommended during chipper operations.
KW - WORK-related injuries
KW - CHIPPERS (Landscape equipment)
KW - DEATH
KW - WOUNDS & injuries
KW - EMPLOYEES
KW - PROTECTIVE clothing
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States. Bureau of Labor Statistics
N1 - Accession Number: 15345442; Struttmann, T. W. 1; Affiliation: 1: Div of Safety Research, National Institute for Occupational Safety and Health, CDC; Source Info: 12/10/2004, Vol. 53 Issue 48, p1130; Subject Term: WORK-related injuries; Subject Term: CHIPPERS (Landscape equipment); Subject Term: DEATH; Subject Term: WOUNDS & injuries; Subject Term: EMPLOYEES; Subject Term: PROTECTIVE clothing; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: UNITED States. Bureau of Labor Statistics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 113310 Logging; NAICS/Industry Codes: 333120 Construction Machinery Manufacturing; NAICS/Industry Codes: 333247 Paper industry machinery manufacturing; NAICS/Industry Codes: 333112 Lawn and Garden Tractor and Home Lawn and Garden Equipment Manufacturing; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15345442&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, H.W.
AU - Barger, M.W.
AU - Ma, J.K.H.
AU - Castranova, V.
AU - Ma, J.Y.C.
T1 - Effects of exposure to diesel exhaust particles (DEP) on pulmonary metabolic activation of mutagenic agents
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2004/12/12/
VL - 564
IS - 2
M3 - Article
SP - 103
EP - 113
SN - 13835718
AB - Exposure of rats to diesel exhaust particles (DEP) or carbon black (CB) has been shown to induce time-dependent changes in CYP1A1and CYP2B1 in the lung. The present study evaluated the role of these metabolic enzymes on the pulmonary bioactivation of mutagens. Male Sprague–Dawley rats were intratracheally instilled with saline (control), DEP or CB (35mg/kg body weight) and sacrificed at 1, 3, or 7 days post-exposure. Both control and exposed lung S9 increased the mutagenic activity of 2-aminoanthracene (2-AA), 2-aminofluorene (2-AF), 1-nitropyrene (1-NP), and the organic extract of DEP (DEPE) in Ames tests with Salmonella typhimurium YG1024 in a dose-dependent manner. Lung microsomes prepared form control or particle-exposed S9, but not cytosolic protein, activated 2-AA mutagenicity. Compared to saline controls, CB-exposed S9 was a less potent inducer of 2-AA mutagenicity at all time points, whereas DEP-exposed S9 was less potent than control saline at 3 and 7 days but not 1 day post-exposure. At 3 days post-exposure, DEP- or CB-exposed lung S9 did not significantly affect the mutagenicity of DEPE or 1-NP, when compared to the controls. The mutgenicity of 2-AA, 2-AF, 1-NP, and DEPE were significantly decreased in the presence of inhibitors for CYP1A1 (α-naphthoflavone) or CYP2B (metyrapone), but markedly enhanced by CYP1A1 or CYP2B1 supersomes with all the cofactors, suggesting that both CYP1A1 and CYP2B1 were responsible for mutagen activation. These results demonstrated that exposure of rats to DEP or CB altered metabolic activity of lung S9 and S9 metabolic activity dependent mutagen activation. The bioactivation of mutagens are metabolic enzyme- and substrate-specific, and both CYP1A1 and CYP2B1 play important roles in pulmonary mutagen activation. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Body composition
KW - Enterobacteriaceae
KW - Mutagenesis
KW - Salmonella typhimurium
KW - Carbon black
KW - CYP1A1
KW - CYP2B1
KW - Diesel exhaust particles
KW - Mutagenicity
N1 - Accession Number: 14786638; Zhao, H.W. 1; Barger, M.W. 1; Ma, J.K.H. 2; Castranova, V. 1; Ma, J.Y.C.; Email Address: jym1@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA; 2: School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Issue Info: Dec2004, Vol. 564 Issue 2, p103; Thesaurus Term: Body composition; Thesaurus Term: Enterobacteriaceae; Subject Term: Mutagenesis; Subject Term: Salmonella typhimurium; Author-Supplied Keyword: Carbon black; Author-Supplied Keyword: CYP1A1; Author-Supplied Keyword: CYP2B1; Author-Supplied Keyword: Diesel exhaust particles; Author-Supplied Keyword: Mutagenicity; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mrgentox.2004.07.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106590465
T1 - Reflections on a decade of device review at the FDA...second in a series
AU - Cygnarowicz T
Y1 - 2004/12/14/
N1 - Accession Number: 106590465. Language: English. Entry Date: 20050311. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; USA. NLM UID: 9890324.
KW - Audiologists
KW - Product Evaluation
KW - United States Food and Drug Administration
KW - Cochlear Implant
KW - Hearing Aids
KW - Quality Control (Technology)
SP - 17
EP - 18
JO - ASHA Leader
JF - ASHA Leader
JA - ASHA LEADER
VL - 9
IS - 22
CY - Rockville, Maryland
PB - American Speech-Language-Hearing Association
SN - 1085-9586
AD - Scientific Reviewer/Audiologist, Ear, Nose and Throat Devices Branch, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Sung Hee
AU - Seo, Geom Seog
AU - Park, Young Nyun
AU - Yoo, Tae Moo
AU - Sohn, Dong Hwan
T1 - Effects and regulation of osteopontin in rat hepatic stellate cells
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2004/12/15/
VL - 68
IS - 12
M3 - Article
SP - 2367
EP - 2378
SN - 00062952
AB - Abstract: Using a cDNA microarray, we identified osteopontin (OPN) as one of the genes upregulated in cultured activated hepatic stellate cells (HSCs). Northern and western blot analyses showed that OPN was increasingly expressed during the progressive activation of cultured rat HSCs, and a significant increase in OPN was observed in carbon tetrachloride-induced rat liver fibrosis. In biliary atresia, OPN protein was predominantly expressed in Kupffer cells and HSCs in the necrotic areas. Incubation of HSCs with recombinant OPN-induced significant proliferative and migratory effects, and induced matrix metalloproteinase 2 production and activation. Moreover, OPN increased type I collagen production and type II transforming growth factor-β receptor mRNA and protein. In conclusion, this study shows that OPN is expressed in activated HSCs and suggests that the upregulation of OPN might be a central pathway of HSC activation. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL adhesion molecules
KW - CYTOKINES
KW - CONNECTIVE tissues
KW - EXTRACELLULAR matrix
KW - receptor (type II TGF-β )
KW - ECM, extracellular matrix
KW - MMP-2, matrix metalloproteinase 2
KW - MTI-MMP, membrane type I matrix metalloproteinase
KW - OPN, osteopontin
KW - PDGF, platelet-derived growth factor
KW - TβRII
KW - TGF-β, transforming growth factor β
KW - TIMP-2 t, issue inhibitor of metalloproteinase 2
N1 - Accession Number: 15449753; Lee, Sung Hee 1 Seo, Geom Seog 2 Park, Young Nyun 3 Yoo, Tae Moo 4 Sohn, Dong Hwan 1; Email Address: dhsohn@wonkwang.ac.kr; Affiliation: 1: Medicinal Resources Research Center, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea 2: Department of Internal Medicine, Wonkwang University Medical School, Iksan, Jeonbuk 570-749, Republic of Korea 3: Department of Pathology and Brain Korea 21 project for Medical Science, Center for Chronic Metabolic Disease Research, Yonsei University College of Medicine, Seoul 120-749, Republic of Korea 4: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Dec2004, Vol. 68 Issue 12, p2367; Subject Term: CELL adhesion molecules; Subject Term: CYTOKINES; Subject Term: CONNECTIVE tissues; Subject Term: EXTRACELLULAR matrix; Author-Supplied Keyword: receptor (type II TGF-β ); Author-Supplied Keyword: ECM, extracellular matrix; Author-Supplied Keyword: MMP-2, matrix metalloproteinase 2; Author-Supplied Keyword: MTI-MMP, membrane type I matrix metalloproteinase; Author-Supplied Keyword: OPN, osteopontin; Author-Supplied Keyword: PDGF, platelet-derived growth factor; Author-Supplied Keyword: TβRII; Author-Supplied Keyword: TGF-β, transforming growth factor β; Author-Supplied Keyword: TIMP-2 t, issue inhibitor of metalloproteinase 2; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bcp.2004.08.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krauthamer, V.
AU - Smith, T. C.
T1 - Acute effects of adrenergic agents on post-defibrillation arrest time in a cultured heart model.
JO - Cellular & Molecular Life Sciences
JF - Cellular & Molecular Life Sciences
Y1 - 2004/12/15/
VL - 61
IS - 24
M3 - Article
SP - 3093
EP - 3099
SN - 1420682X
AB - Possible drug interactions with electrical defibrillation were examined. We tested the hypothesis that adrenergic agents (epinephrine, norepinephrine, isoproterenol) and a calcium channel blocker (verapamil), when applied acutely, alter the duration of arrest following a defibrillator shock. A secondary hypothesis (based on observations) was that the drugs alter the occurrence of changes to normal rhythms following the shock. Dissociated heart cells from 10-day chicken embryos were cultured to form spherical aggregates and plated in petri dishes. In the experiments, the spheres were paced at 0.75 V/cm above contraction threshold, and a biphasic defibrillator shock was applied for 1 ms at 46 V/cm. The arrest time and occurrence of rhythm changes were recorded. The adrenergic agents shortened the duration of arrest following a defibrillator shock, while the calcium channel blocker lengthened the arrest time. Comparisons with the control proportion of double beats showed no significant change with the adrenergic agents and a decrease with verapamil. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular & Molecular Life Sciences is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTROPORATION
KW - ADRENALINE
KW - NORADRENALINE
KW - ISOPROTERENOL
KW - VERAPAMIL
KW - asystole
KW - bigeminy
KW - Electroporation
KW - epinephrine
KW - isoproterenol
KW - norepinephrine
KW - verapamil
N1 - Accession Number: 15276311; Krauthamer, V. 1; Email Address: victor.krauthamer@hhs.fda.gov Smith, T. C. 1,2; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, 12725 Twinbrook Parkway, Mail stop HFZ-130, Rockville, Maryland 20852 (USA) 2: National Institute of Biomedical Imaging and Bioengineering, 6707 Democracy Boulevard -- Suite 200, Bethesda, Maryland 20892 (USA); Source Info: Dec2004, Vol. 61 Issue 24, p3093; Subject Term: ELECTROPORATION; Subject Term: ADRENALINE; Subject Term: NORADRENALINE; Subject Term: ISOPROTERENOL; Subject Term: VERAPAMIL; Author-Supplied Keyword: asystole; Author-Supplied Keyword: bigeminy; Author-Supplied Keyword: Electroporation; Author-Supplied Keyword: epinephrine; Author-Supplied Keyword: isoproterenol; Author-Supplied Keyword: norepinephrine; Author-Supplied Keyword: verapamil; Number of Pages: 7p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1007/s00018-004-4372-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leonard, Stephen S.
AU - Harris, Gabriel K.
AU - Shi, Xianglin
T1 - Metal-induced oxidative stress and signal transduction
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2004/12/15/
VL - 37
IS - 12
M3 - Article
SP - 1921
EP - 1942
SN - 08915849
AB - Abstract: Occupational and environmental exposures to metals are associated with the development of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the mechanisms of action, especially at the molecular level, are still unclear. Accumulating evidence indicates that reactive oxygen species generated by metals may play an important role in the etiology of disease. This review covers recent advances in (1) metal-induced generation of reactive oxygen species; (2) the receptors, kinases, and nuclear transcription factors affected by metals and metal-induced oxidative stress, including growth factor receptors, src kinase, ras signaling, mitogen-activated protein kinases, the phosphoinositide 3-phosphate/Akt pathway, nuclear transcription factor κB, activator protein 1, p53, nuclear factor of activated T cells, and hypoxia-inducible factor 1; and (3) global cellular phenomena (signal transduction, cell cycle regulation, and apoptosis) associated with metal-induced ROS production and gene expression. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMAL growth factor
KW - CYTOKINES
KW - METALLURGY
KW - PROTEIN kinases
KW - activator protein-1 (AP-1)
KW - ataxia–telangiectasia mutated (ATM)
KW - ATM and Rad3-related (ATR)
KW - big MAPK-1 (BMAPK-1)
KW - c-jun-NH2-terminal kinase (JNK)
KW - cultured granular progenitors (CGP)
KW - epidermal growth factor (EGF)
KW - extracellular-regulated kinase (ERK)
KW - Fas-associated death domain (FADD)
KW - gene arrest and DNA damage (GADD)
KW - heme-oxygenase 1 (HO-1)
KW - human analog of v-Akt mouse lymphoma retrovirus protein (Akt)
KW - hypoxia-inducible factor 1 (HIF-1)
KW - inhibitory κB kinase (IKK)
KW - interleukin (IL)
KW - MAPK/ERK kinase (MEK)
KW - mitogen-activated protein kinase (MAPK)
KW - murine double minute 2 (mdm2)
KW - nonreceptor tyrosine kinase (NTK)
KW - nuclear factor of activated T cells (NFAT)
KW - nuclear transcription factor κB (NF-κB)
KW - phosphoinositide 3-kinase (PI3K)
KW - platelet-derived growth factor (PDGF)
KW - protein kinase C (PKC)
KW - reactive oxygen species (ROS)
KW - receptor tyrosine kinase (RTK)
KW - reduced glutathione (GSH)
KW - reduced nicotine adenine dinucleotide phosphate (NADPH)
KW - superoxide dismutase (SOD)
KW - tumor necrosis factor (TNF)
KW - vascular endothelial growth factor (VEGF)
N1 - Accession Number: 15801460; Leonard, Stephen S.; Email Address: SEL5@cdc.gov Harris, Gabriel K. 1 Shi, Xianglin 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Dec2004, Vol. 37 Issue 12, p1921; Subject Term: EPIDERMAL growth factor; Subject Term: CYTOKINES; Subject Term: METALLURGY; Subject Term: PROTEIN kinases; Author-Supplied Keyword: activator protein-1 (AP-1); Author-Supplied Keyword: ataxia–telangiectasia mutated (ATM); Author-Supplied Keyword: ATM and Rad3-related (ATR); Author-Supplied Keyword: big MAPK-1 (BMAPK-1); Author-Supplied Keyword: c-jun-NH2-terminal kinase (JNK); Author-Supplied Keyword: cultured granular progenitors (CGP); Author-Supplied Keyword: epidermal growth factor (EGF); Author-Supplied Keyword: extracellular-regulated kinase (ERK); Author-Supplied Keyword: Fas-associated death domain (FADD); Author-Supplied Keyword: gene arrest and DNA damage (GADD); Author-Supplied Keyword: heme-oxygenase 1 (HO-1); Author-Supplied Keyword: human analog of v-Akt mouse lymphoma retrovirus protein (Akt); Author-Supplied Keyword: hypoxia-inducible factor 1 (HIF-1); Author-Supplied Keyword: inhibitory κB kinase (IKK); Author-Supplied Keyword: interleukin (IL); Author-Supplied Keyword: MAPK/ERK kinase (MEK); Author-Supplied Keyword: mitogen-activated protein kinase (MAPK); Author-Supplied Keyword: murine double minute 2 (mdm2); Author-Supplied Keyword: nonreceptor tyrosine kinase (NTK); Author-Supplied Keyword: nuclear factor of activated T cells (NFAT); Author-Supplied Keyword: nuclear transcription factor κB (NF-κB); Author-Supplied Keyword: phosphoinositide 3-kinase (PI3K); Author-Supplied Keyword: platelet-derived growth factor (PDGF); Author-Supplied Keyword: protein kinase C (PKC); Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: receptor tyrosine kinase (RTK); Author-Supplied Keyword: reduced glutathione (GSH); Author-Supplied Keyword: reduced nicotine adenine dinucleotide phosphate (NADPH); Author-Supplied Keyword: superoxide dismutase (SOD); Author-Supplied Keyword: tumor necrosis factor (TNF); Author-Supplied Keyword: vascular endothelial growth factor (VEGF); Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2004.09.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Correa-de-Araujo, Rosaly
AU - Clancy, Carolyn
T1 - Principles of Gender-Specific Medicine, vols 1 & 2.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2004/12/15/
VL - 292
IS - 23
M3 - Book Review
SP - 2921
EP - 2922
SN - 00987484
AB - Reviews the book "Principles of Gender-Specific Medicine, vols. 1 & 2," edited by Marianne J. Legato.
KW - MEDICINE
KW - NONFICTION
KW - BOOK REVIEWS (Meyer HS, ed)
KW - LEGATO, Marianne
KW - PRINCIPLES of Gender-Specific Medicine (Book)
N1 - Accession Number: 15359235; Correa-de-Araujo, Rosaly 1; Email Address: rcorrea@.ahrq.gov Clancy, Carolyn 2; Email Address: cclancy@ahrq.gov; Affiliation: 1: 1 2: Agency for Healthcare Research and Quality, DHHS Rockville, Md; Source Info: 12/15/2004, Vol. 292 Issue 23, p2921; Subject Term: MEDICINE; Subject Term: NONFICTION; Author-Supplied Keyword: BOOK REVIEWS (Meyer HS, ed); Reviews & Products: PRINCIPLES of Gender-Specific Medicine (Book); People: LEGATO, Marianne; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomason, Lynn C.
AU - Court, Donald L.
AU - Datta, Atin R.
AU - Khanna, Rita
AU - Rosner, Judah L.
T1 - Identification of the Escherichia coli K-12 ybhE Gene as pgl, Encoding 6-Phosphogluconolactonase.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2004/12/15/
VL - 186
IS - 24
M3 - Article
SP - 8248
EP - 8253
SN - 00219193
AB - We report identification of the Escherichia coli ybhE gene as the pg1 gene that encodes 6-phosphoglucono- lactonase. A tentative identification was first made based on the known approximate location of the pg1 gene and the similarity of the presumptive ybhE-encoded protein sequence to a known Pgl enzyme. To test this notion, the ybhE gene was deleted and replaced with a drug marker. Like previously characterized pg1 mutants, the ybhE deletion mutant had a Blu- phenotype (dark-blue staining with iodine due to accumulation of starch after growth on minimal maltose) and demonstrated impaired growth on minimal glucose medium when combined with a pgi mutation. Biochemical assay of crude extracts for 6-phosphogluconolactonase enzymatic activity showed that ybhE encodes this activity. The ybhE gene was transferred from the E. coli chromosome to an expression vector. This ybhE clone complemented both the precise deletion of the ybhE gene and a larger deletion, pglΔ8, for the Blu- phenotype and for phosphogluconolactonase activity, confirming that ybhE is the pg1 gene. A newly observed phenotype of pg1 strains is a lowered frequency of appearance of Bgl+ mutants that can utilize the β-glucoside salicin. This is likely due to poor growth of Bgl+ pg1 strains on salicin due to the accumulation of 6-phosphogluconolactone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - ESCHERICHIA
KW - GENES
KW - PROTEINS
KW - ENZYMES
KW - PHENOTYPE
N1 - Accession Number: 15513242; Thomason, Lynn C. 1; Email Address: lthomason@ncifcrf.gov Court, Donald L. 1 Datta, Atin R. 2,3 Khanna, Rita 2,4 Rosner, Judah L. 2; Affiliation: 1: Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland 2: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 3: Food and Drug Administration, Rockville, MD 20857 4: International Technology Transfer Management, Inc., Bethesda, MD 20817; Source Info: Dec2004, Vol. 186 Issue 24, p8248; Subject Term: ESCHERICHIA coli; Subject Term: ESCHERICHIA; Subject Term: GENES; Subject Term: PROTEINS; Subject Term: ENZYMES; Subject Term: PHENOTYPE; Number of Pages: 6p; Illustrations: 4 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/JB.186.24.8248-8253.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crill, Wayne D.
AU - Chang, Gwong-Jen J.
T1 - Localization and Characterization of Flavivirus Envelope Glycoprotein Cross-Reactive Epitopes.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2004/12/15/
VL - 78
IS - 24
M3 - Article
SP - 13975
EP - 13986
SN - 0022538X
AB - The flavivirus E glycoprotein, the primary antigen that induces protective immunity, is essential for membrane fusion and mediates binding to cellular receptors. Human flavivirus infections stimulate virus species-specific as well as flavivirus cross-reactive immune responses. Flavivirus cross-reactive antibodies in human sera create a serious problem for serodiagnosis, especially for secondary flavivirus infections, due to the difficulty of differentiating primary from secondary cross-reactive serum antibodies. The presence of subneutralizing levels of flavivirus cross-reactive serum antibodies may result in a dramatic increase in the severity of secondary flavivirus infections via antibody-dependent enhancement. An understanding of flavivirus E-glycoprotein cross-reactive epitopes is therefore critical for improving public health responses to these serious diseases. We identified six E-glycoprotein residues that are incorporated into three distinct flavivirus cross-reactive epitopes. Two of these epitopes which are recognized by distinct monoclonal antibodies contain overlapping continuous residues located within the highly conserved fusion peptide. The third epitope consists of discontinuous residues that are structurally related to the strictly conserved tryptophan at dengue virus serotype 2 E-glycoprotein position 231. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVIVIRUSES
KW - ARBOVIRUSES
KW - TOGAVIRUSES
KW - GLYCOPROTEINS
KW - GLYCOCONJUGATES
KW - ANTIGENIC determinants
KW - ANTIGENS
N1 - Accession Number: 15499534; Crill, Wayne D. 1; Email Address: wcrill@cdc.gov Chang, Gwong-Jen J. 1; Affiliation: 1: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S. Department of Health and Human Services, Fort Collins, Colorado; Source Info: Dec2004, Vol. 78 Issue 24, p13975; Subject Term: FLAVIVIRUSES; Subject Term: ARBOVIRUSES; Subject Term: TOGAVIRUSES; Subject Term: GLYCOPROTEINS; Subject Term: GLYCOCONJUGATES; Subject Term: ANTIGENIC determinants; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Illustrations: 2 Color Photographs, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/JVI.78.24.13975-13986.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slikker, William
AU - Andersen, Melvin E.
AU - Bogdanffy, Matthew S.
AU - Bus, James S.
AU - Cohen, Steven D.
AU - Conolly, Rory B.
AU - David, Raymond M.
AU - Doerrer, Nancy G.
AU - Dorman, David C.
AU - Gaylor, David W.
AU - Hattis, Dale
AU - Rogers, John M.
AU - Woodrow Setzer, R.
AU - Swenberg, James A.
AU - Wallace, Kendall
T1 - Dose-dependent transitions in mechanisms of toxicity
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2004/12/15/
VL - 201
IS - 3
M3 - Article
SP - 203
EP - 225
SN - 0041008X
AB - Abstract: Scientists and decision makers from all sectors agree that risk assessments should be based on the best available science. Several years ago, the Health and Environmental Sciences Institute (HESI), a global branch of the International Life Sciences Institute (ILSI), identified the need for better scientific understanding of dose-dependent transitions in mechanisms of toxicity as one avenue by which the best and latest science can be integrated into the decision making process. In July 2001, the HESI Project Committee on Dose-Dependent Transitions in Mechanisms of Toxicity established a group of academic, government, and industry scientists to engage in active technical discourse on the issue of dose-dependent transitions in mechanisms of toxicity. Over the next 18 months, case studies were examined. These case studies included acetaminophen, butadiene, ethylene glycol, formaldehyde, manganese, methylene chloride, the peroxisome proliferator-activated receptor, progesterone/hydroxyflutamide, propylene oxide, vinyl acetate, vinyl chloride, vinylidene chloride, and zinc (Slikker, W., Jr., Andersen, M.E., Bogdanffy, M.S., Bus, J.S., Cohen, S.D., Conolly, R.B., David, R.M., Doerrer, N.G., Dorman, D.C., Gaylor, D.W., Hattis, D., Rogers, J.M., Setzer, R.W., Swenberg, J.A., Wallace, K., 2004. Dose-dependent transitions in mechanisms of toxicity: case studies. Toxicol. Appl. Pharmacol. 201(3), 226–294 (this issue)). The HESI Project Committee sponsored two technical workshops in 2003. The first of these workshops took place on February 12–13, 2003, and was co-sponsored by the Agency for Toxic Substances and Disease Registry, the American Chemistry Council, the National Institute of Environmental Health Sciences, the Society of Toxicology, and the U.S. Environmental Protection Agency. Additional support was provided by Health Canada. Invited experts from government, academia, and industry provided scientific perspectives and recommendations at the workshop. The purpose of the workshop was to examine approaches to dose–response analysis, learn from the case study examples, and gather feedback from invited participants on the impact of dose-dependent transitions on the risk assessment process. The second forum consisted of a workshop in March 2003 at the Society of Toxicology Annual Meeting in Salt Lake City, UT. This paper addresses the issues discussed at both workshops, and presents the consensus conclusions drawn by expert participants. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisons
KW - Dose-response relationship (Biochemistry)
KW - Public health
KW - Vinyl polymers
KW - Dose–response
KW - Dose-dependent transitions
KW - Mechanisms of toxicity
N1 - Accession Number: 15562768; Slikker, William 1; Andersen, Melvin E. 2; Bogdanffy, Matthew S. 3; Bus, James S. 4; Cohen, Steven D. 5; Conolly, Rory B. 2; David, Raymond M. 6; Doerrer, Nancy G. 7; Email Address: ndoerrer@ilsi.org; Dorman, David C. 2; Gaylor, David W. 8; Hattis, Dale 9; Rogers, John M. 10; Woodrow Setzer, R. 10; Swenberg, James A. 11; Wallace, Kendall 12; Affiliations: 1: U.S. FDA National Center for Toxicological Research, Jefferson, AR 72079, USA; 2: CIIT Centers for Health Research, Research Triangle Park, NC 27709-2137, USA; 3: DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714, USA; 4: The Dow Chemical Company, Midland, MI 48674, USA; 5: Massachusetts College of Pharmacy, Worcester, MA 01610, USA; 6: Eastman Kodak Company, Rochester, NY 14652-6272, USA; 7: ILSI Health and Environmental Sciences Institute, Washington, DC 20005, USA; 8: Gaylor and Associates, LLC, Eureka Springs, AR 72631, USA; 9: Clark University, Worcester, MA 01610, USA; 10: U.S. EPA National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA; 11: University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; 12: University of Minnesota, Duluth, MN 55812-2487, USA; Issue Info: Dec2004, Vol. 201 Issue 3, p203; Thesaurus Term: Poisons; Thesaurus Term: Dose-response relationship (Biochemistry); Thesaurus Term: Public health; Subject Term: Vinyl polymers; Author-Supplied Keyword: Dose–response; Author-Supplied Keyword: Dose-dependent transitions; Author-Supplied Keyword: Mechanisms of toxicity; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 23p; Document Type: Article
L3 - 10.1016/j.taap.2004.06.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=15562768&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yarovinsky, Felix
AU - Andersen, John F.
AU - King, Lisa R.
AU - Caspar, Patricia
AU - Aliberti, Julio
AU - Golding, Hana
AU - Sher, Alan
T1 - Structural Determinants of the Anti-HIV Activity of a CCR5 Antagonist Derived from Toxoplasma gondii.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/12/17/
VL - 279
IS - 51
M3 - Article
SP - 53635
EP - 53642
SN - 00219258
AB - The protozoan parasite Toxoplasma gondii possesses a protein, cyclophilin-18 (C-18), which binds to the chemokine receptor CCR5, induces interleukin-12 production from murine dendritic cells, and inhibits fusion and infectivity of human immunodeficiency virus 1 (HIV-1) R5 viruses by co-receptor antagonism. Site-directed mutagenesis was employed to identify the domains in C-18 responsible for its CCR5 binding and antiviral functions. To do so we focused on amino acid differences with Plasmodium falciparum cyclophilin, which, although 53% identical with C-18, has minimal binding activity for CCR5, and we generated 22 mutants with substitutions in the regions of non-homology located on the putative surface of the molecule. Two mutations situated on the face of C-18, predicted to be involved in its interaction with the ligand cyclosporin A, were shown to be critical for CCR5-binding and the inhibition of HIV-1 fusion and infectivity. In contrast, four mutations in C-18 specifically designed to abolish the peptidyl-prolyl cis-trans-isomerase activity of the protein failed to inactivate its CCR5 binding and HIV inhibitory activities. Interleukin-12 induction by C-18, on the other hand, was abrogated by mutations effecting either the CCR5 binding or enzymatic function of the molecule. These findings shed light on the structural basis of the molecular mimicry of the chemokine function by a pathogen-derived protein and provide a basis for further modification of C-18 into an antiviral agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXOPLASMA gondii
KW - PEPTIDYLPROLYL isomerase
KW - ANTIRETROVIRAL agents
KW - HIV infections -- Prevention
KW - HIV (Viruses)
KW - MUTAGENESIS
N1 - Accession Number: 15678784; Yarovinsky, Felix 1 Andersen, John F. 2 King, Lisa R. 3 Caspar, Patricia 1 Aliberti, Julio 1,4 Golding, Hana 3 Sher, Alan 1; Email Address: asher@mail.nih.gov; Affiliation: 1: Immunobiology Section, Laboratory of Parasitic Diseases 2: Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 3: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4: Dept. of Immunology, Duke University Medical Center, Durham, NC 27710; Source Info: 12/17/2004, Vol. 279 Issue 51, p53635; Subject Term: TOXOPLASMA gondii; Subject Term: PEPTIDYLPROLYL isomerase; Subject Term: ANTIRETROVIRAL agents; Subject Term: HIV infections -- Prevention; Subject Term: HIV (Viruses); Subject Term: MUTAGENESIS; Number of Pages: 8p; Illustrations: 2 Diagrams, 13 Graphs; Document Type: Article
L3 - 10.1074/jbc.M410550200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Finlayson, J.S.
T1 - John Ferry—the most important man I never knew
JO - Biophysical Chemistry
JF - Biophysical Chemistry
Y1 - 2004/12/20/
VL - 112
IS - 2/3
M3 - Article
SP - 153
EP - 154
SN - 03014622
N1 - Accession Number: 15552808; Finlayson, J.S. 1; Email Address: scottd@cber.fda.gov; Affiliation: 1: Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, United States; Source Info: Dec2004, Vol. 112 Issue 2/3, p153; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.bpc.2004.07.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15552808&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Derrick, Steven C.
AU - Yang, Amy Li
AU - Morris, Sheldon L.
T1 - A polyvalent DNA vaccine expressing an ESAT6–Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity
JO - Vaccine
JF - Vaccine
Y1 - 2004/12/21/
VL - 23
IS - 6
M3 - Article
SP - 780
EP - 788
SN - 0264410X
AB - Abstract: In this study, we evaluated the protective efficacy of a DNA vaccine (pE6/85) expressing an ESAT6–Ag85B fusion protein against a primary Mycobacterium tuberculosis infection in mice. In short-term studies, vaccination with pE6/85 protected as well as Mycobacterium bovis BCG immunization with similar lung pathology and bacterial burdens detected 28 days after a low dose aerogenic challenge (>1.0log10 reduction relative to naïves). In a survival experiment, the protection induced by pE6/85 immunization was also not significantly different than that elicited by BCG vaccination with the mean-times-to-death (±standard error of the mean) being 102±20, 271±32 and 299±14 days for naïve, pE6/85 and BCG-vaccinated mice, respectively. Furthermore, boosting with pE6/85 but not BCG or a DNA vaccine cocktail at 1 year after an initial BCG immunization (when BCG-induced protection was declining), augmented protection in the lung at 15 and 18 months to levels detected at 3 months post-BCG vaccination. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Immunization
KW - DNA vaccines
KW - Vaccines
KW - BCG
KW - Tuberculosis
KW - Vaccine
N1 - Accession Number: 15425642; Derrick, Steven C. 1; Yang, Amy Li 1; Morris, Sheldon L.; Email Address: morris@cber.fda.gov; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Building 29, Room 502, CBER/FDA, 29 Lincoln Drive, Bethesda, MD 20892, USA; Issue Info: Dec2004, Vol. 23 Issue 6, p780; Thesaurus Term: Vaccination; Thesaurus Term: Immunization; Subject Term: DNA vaccines; Subject Term: Vaccines; Author-Supplied Keyword: BCG; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.07.036
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Srisodsai, Achara
AU - Kurotani, Reiko
AU - Chiba, Yoshihiko
AU - Sheikh, Faruk
AU - Young, Howard A.
AU - Donnelly, Raymond P.
AU - Kimura, Shioko
T1 - Interleukin-10 Induces Uteroglobin-related Protein (UGRP) 1 Gene Expression in Lung Epithelial Cells through Homeodomain Transcription Factor T/EBP/NKX2.1.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2004/12/24/
VL - 279
IS - 52
M3 - Article
SP - 54358
EP - 54368
SN - 00219258
AB - UGRP1 is a downstream target gene for homeodomain transcription factor T/EBP/NKX2.1, which is predominantly expressed in lung epithelial cells, and may play an anti-inflammatory role in lung inflammation. To understand the role of UGRP1 in inflammation, its expression was investigated in relation to cytokine signaling. In vivo experiments using mouse embryonic lung organ culture and intranasal administration of interleukin (IL) 10 revealed that constitutive expression of Ugrp1 mRNA is enhanced by IL-10. Increase of protein levels was also demonstrated by immunohistochemistry using embryonic lungs. This IL-10 induction of Ugrp1 gene expression occurs at the transcriptional level when examined using mouse embryonic lung primary cultures. In human lung NCI-H441 cells that in contrast to mouse lung cells, do not exhibit constitutive expression of the gene, expression of the UGRP1 gene was induced in a rapid and stable fashion. Two T/EBP, but not STAT3, binding sites located in the human UGRP1 gene promoter are responsible for IL-10 induction of the UGRP1 gene as judged by transfection, gel shift, and chromatin immunoprecipitation analyses. The IL-10 receptor chains, IL-10R1 and IL-10R2, are expressed in H441 cells, however, STAT3 was only weakly activated upon IL-10 treatment. In contrast, STAT3 was strongly activated when the cells were treated with other cytokines such as IL-22 and interferon-β but UGRP1 expression was not increased. Together these results demonstrate that IL-10 induces UGRP1 gene expression in lung epithelial cells through a T/EBP/NKX2.1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-10
KW - GENE expression
KW - UTEROGLOBIN
KW - TRANSCRIPTION factors
KW - EPITHELIAL cells
KW - LYMPHOCYTES
KW - GLYCOPROTEINS
N1 - Accession Number: 15727092; Srisodsai, Achara 1 Kurotani, Reiko 1 Chiba, Yoshihiko 1,2 Sheikh, Faruk 3 Young, Howard A. 4 Donnelly, Raymond P. 3 Kimura, Shioko 1; Email Address: shioko@helix.nih.gov; Affiliation: 1: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 2: Dept. of Pharmacology, School of Pharmacy, Hoshi University, Tokyo 142-8501, Japan 3: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4: Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland 21701; Source Info: 12/24/2004, Vol. 279 Issue 52, p54358; Subject Term: INTERLEUKIN-10; Subject Term: GENE expression; Subject Term: UTEROGLOBIN; Subject Term: TRANSCRIPTION factors; Subject Term: EPITHELIAL cells; Subject Term: LYMPHOCYTES; Subject Term: GLYCOPROTEINS; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 5 Graphs; Document Type: Article
L3 - 10.1074/jbc.M405331200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15727092&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kreiss, K.
AU - Rao, C. Y.
AU - Harrison, J. M.
T1 - Investigation of a Home with Extremely Elevated Carbon Dioxide Levels -- West Virginia, December 2003.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2004/12/24/
VL - 53
IS - 50
M3 - Article
SP - 1181
EP - 1182
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Documents the investigation on carbon dioxide exposures at a home in West Virginia in which the occupants had respiratory and neurologic symptoms. Facts of the case; Discovery of low oxygen and carbon dioxide concentrations in the home; Equipment used for short-term sampling and monitoring carbon dioxide concentrations; Indication of the carbon isotopic composition analysis of air samples.
KW - AIR analysis
KW - CARBON dioxide
KW - OXYGEN
KW - AIR quality
KW - RESPIRATORY diseases
KW - WEST Virginia
N1 - Accession Number: 15495024; Kreiss, K. 1 Rao, C. Y. 1 Harrison, J. M. 1; Affiliation: 1: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health; Source Info: 12/24/2004, Vol. 53 Issue 50, p1181; Subject Term: AIR analysis; Subject Term: CARBON dioxide; Subject Term: OXYGEN; Subject Term: AIR quality; Subject Term: RESPIRATORY diseases; Subject Term: WEST Virginia; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Lee D.
AU - Churchwell, Mona I.
AU - Doerge, Daniel R.
T1 - Multiresidue confirmation of β-agonists in bovine retina and liver using LC-ES/MS/MS
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2004/12/25/
VL - 813
IS - 1/2
M3 - Article
SP - 35
EP - 45
SN - 15700232
AB - Abstract: Misuse of numerous β-agonist drugs for their growth promoting effects in livestock production requires significant regulatory enforcement activities worldwide. The proof of illegal drug use needed for regulatory action usually requires the high degree of specificity derived from mass spectrometric analysis of suspect tissues and body fluids. In this paper, we describe a multiresidue screening method for confirmation of nine β-agonist compounds in bovine liver and retina. A wide range of analyte structures was selected in order to demonstrate applicability to other chemically related β-agonists for which standards are not currently available. The class-specific method, which is based on mixed mode cation exchange/reverse phase solid phase extraction, reverse phase gradient LC separation using a cyanopropyl-silica phase, and tandem mass spectrometry (MS/MS) in the multiple reaction monitoring (MRM) mode, yields high analyte recoveries at the target level of 1ppb (ng/g). In addition, acquisition of multiple MRM transitions for each analyte permits simultaneous confirmation of β-agonists at the level of 1ppb in liver and retina by using intensity ratios between fragment ions and protonated molecules. Estimated values for the limit of quantification (LOQ) for individual β-agonists were 0.08–0.3ppb in liver and 0.02–0.5 in retina; the estimated limits of confirmation, using accepted criteria from international regulatory agencies, were 0.25–0.8ppb in liver and 0.1–1ppb in retina. This method should be useful in supporting regulatory enforcement programs that monitor β-agonist misuse. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVESTOCK
KW - DRUGS
KW - MASS spectrometry
KW - BODY fluids
KW - LIVER
KW - β-Agonists
KW - Clenbuterol
KW - Mass spectrometry
KW - Ractopamine
KW - Retina
N1 - Accession Number: 15446731; Williams, Lee D. 1 Churchwell, Mona I. 1 Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov; Affiliation: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Dec2004, Vol. 813 Issue 1/2, p35; Subject Term: LIVESTOCK; Subject Term: DRUGS; Subject Term: MASS spectrometry; Subject Term: BODY fluids; Subject Term: LIVER; Author-Supplied Keyword: β-Agonists; Author-Supplied Keyword: Clenbuterol; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Ractopamine; Author-Supplied Keyword: Retina; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jchromb.2004.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15446731&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Angeles-Boza, Alfredo M.
AU - Bradley, Patricia M.
AU - Fu, Patty K.-L.
AU - Wicke, Sara E.
AU - Bacsa, John
AU - Dunbar, Kim R.
AU - Turro, Claudia
T1 - DNA Binding and Photocleavage in Vitro by New Dirhodium(ll) dppz Complexes: Correlation to Cytotoxicity and Photocytotoxicity.
JO - Inorganic Chemistry
JF - Inorganic Chemistry
Y1 - 2004/12/27/
VL - 43
IS - 26
M3 - Article
SP - 8510
EP - 8519
SN - 00201669
AB - Two new dirhodium(II) complexes possessing the intercalating dppz ligand (dppz = dipyrido[3,2-a:2',3'-c]phenazine), cis-[Rh2(µ-O2CH3)2(dppz)(η¹-O2CCH3)(CH3OH)]+ (1) and cis-[Rh2(µ-O2CCH3)2(dppz)2]2+(2), were synthesized and characterized as potential agents for photochemotherapy. Various techniques show that 1 binds to DNA through intercalation, although some aggregation of the complex on the DNA surface is also present. In contrast, 2 does not intercalate between the DNA bases; however, strong hypochromic behavior is observed in the presence of DNA, which can be attributed to intermolecular π-stacking of 2 enhanced by the polyanion. The apparent DNA binding constants determined using optical titrations are compared to those from dialysis experiments. Both complexes photocleave pUC18 plasmid in vitro under irradiation with visible light (λirr ≥ 395 nm, 15 min), resulting in the nicked, circular form. Greater photocleavage is observed for 1 relative to 2, which may be due to the ability of 1 to intercalate between the DNA bases. The cytotoxicity toward human skin cells (Hs-27) measured as the concentration at which 50% cell death is recorded, LC50, was found to be 135 ± 8 µM for 2 in the dark (30 min), which is significantly lower than those of 1 (LC50 = 27 ± 2 µM) and Rh2(O2CCH3))4 (LC50 = 15 ± 2 µM). (LC50 = 15 ± 2/µM). Irradiation of cell cultures containing 1 and Rh2(O2CCH3)4 with visible light (400-700 nm, 30 min) has little effect on their cytotoxicity, with LC50 values of 21 ± 3 and 13 ± 2 µM, respectively. Interestingly, a 3.4-fold increase in the toxicity of 2 is observed when the cell cultures are irradiated (400-700 nm, 30 min), resulting in LC50 = 39 ± 1 µM. The greater toxicity of 1 compared to 2 in the dark may be related to the ability of the former compound to intercalate between the DNA bases. The lower cytotoxicity of 2, together with its significantly greater photocytotoxicity, makes this complex a potential agent for photodynamic therapy (PDT). These results suggest that intercalation or strong DNA binding may not be a desirable property of a potential PDT agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inorganic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHODIUM compounds
KW - DNA
KW - TOXICITY testing
KW - CLATHRATE compounds
KW - IRRADIATION
KW - CELL culture
N1 - Accession Number: 15728724; Angeles-Boza, Alfredo M. 1 Bradley, Patricia M. 2 Fu, Patty K.-L. 3 Wicke, Sara E. 2 Bacsa, John 1 Dunbar, Kim R. 1; Email Address: dunbar@mail.chem.tamu.edu Turro, Claudia 2; Email Address: turro@chemistry.ohio-state.edu; Affiliation: 1: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210 2: Department of Chemistry, Texas A&M University, College Station, Texas 77843 3: Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, Maryland 20740; Source Info: 12/27/2004, Vol. 43 Issue 26, p8510; Subject Term: RHODIUM compounds; Subject Term: DNA; Subject Term: TOXICITY testing; Subject Term: CLATHRATE compounds; Subject Term: IRRADIATION; Subject Term: CELL culture; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 10p; Illustrations: 4 Diagrams, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ratnasinghe, Luke D.
AU - Abnet, Christian
AU - Qiao, You-Lin
AU - Modali, Rama
AU - Stolzenberg-Solomon, Rachael
AU - Dong, Zhi-Wei
AU - Dawsey, Sanford M.
AU - Mark, Steven D.
AU - Taylor, Philip R.
T1 - Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2004/12/28/
VL - 216
IS - 2
M3 - Article
SP - 157
EP - 164
SN - 03043835
AB - Background: Linxian, a rural county in North Central China, has among the highest rates of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in the world. In a nested case-cohort study that originated from two cancer prevention trials in Linxian, we examined the relationship between these cancers and two polymorphisms in the DNA repair gene XRCC1.Methods: We conducted a case-cohort study among individuals in the cohort who were alive and cancer free in 1991, and had blood samples for DNA extraction. Real time Taqman analyses were conducted to genotype incident cancer cases (n=221, 131 esophageal and 90 gastric cardia cancer cases) that developed through May 1996, and on an age- and sex-matched reference cohort (n=454). We used Cox proportional hazard models to estimate relative risks (RR) and 95% confidence intervals (95% CI).Results: We observed no association between the variant genotype in XRCC1 Arg194Trp (codon 194 arganine to tryptophan substitution) and esophageal or gastric cardia cancer. However, carrying at least one copy of the variant allele in XRCC1 Arg399Gln (codon 399 arganine to glutamine substitution) was associated with reduced risk of gastric cardia cancer (RR: 0.60, 95% CI: 0.37–0.97) and the combined category esophageal/gastric cancer (RR: 0.67, 95% CI: 0.48–0.95). In combined polymorphisms analyses, we observed a significant reduction in risk of combined esophageal/gastric cancer among individuals that had both the XRCC1 Arg194Trp and Arg399Gln variant genotyopes (RR: 0.47, 95% CI: 0.26–0.84).Conclusions: Our results suggest that the XRCC1 Arg399Gln variant genotype is associated with reduced risk of upper GI cancer and that individuals with both XRCC1 variant genotypes are also at significantly reduced risk of upper GI cancer in this high-risk Chinese population. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - GENETIC research
KW - AMINO acids
KW - CANCER
KW - POPULATION genetics
KW - Esophageal cancer
KW - Gastric cardia cancer
KW - XRCC1
KW - Polymorphism
N1 - Accession Number: 14960414; Ratnasinghe, Luke D. 1; Email Address: lratnasinghe@nctr.fda.gov Abnet, Christian 2 Qiao, You-Lin 3 Modali, Rama 4 Stolzenberg-Solomon, Rachael 5 Dong, Zhi-Wei 3 Dawsey, Sanford M. 2 Mark, Steven D. 6 Taylor, Philip R. 2; Affiliation: 1: Center for Structural Genomics, NCTR, Food and Drug Administration, National Center for Toxicological Research/FDA, 3900 NCTR Drive, Jefferson, Arkansas, AR 72079-9502, USA 2: Cancer Prevention Studies Branch, Center for Clinical Research, National Cancer Institute, Rockville, MD, USA 3: Chinese Academy of Medical Sciences, Beijing, China 4: BioServe Biotechnologies, Ltd, Laurel, MD, USA 5: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA 6: Biostatitics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Source Info: Dec2004, Vol. 216 Issue 2, p157; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC research; Subject Term: AMINO acids; Subject Term: CANCER; Subject Term: POPULATION genetics; Author-Supplied Keyword: Esophageal cancer; Author-Supplied Keyword: Gastric cardia cancer; Author-Supplied Keyword: XRCC1; Author-Supplied Keyword: Polymorphism; Language of Keywords: English; Language of Keywords: Chinese; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.canlet.2004.03.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=14960414&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowyer, John F.
AU - Delongchamp, Robert R.
AU - Jakab, Robert L.
T1 - Glutamate N-methyl-d-aspartate and dopamine receptors have contrasting effects on the limbic versus the somatosensory cortex with respect to amphetamine-induced neurodegeneration
JO - Brain Research
JF - Brain Research
Y1 - 2004/12/31/
VL - 1030
IS - 2
M3 - Article
SP - 234
EP - 246
SN - 00068993
AB - Abstract: The roles that glutamate N-methyl-d-aspartate (NMDA) and dopamine D1-like and D2-like receptors play in the cortical neurotoxicity occurring in rats exposed to multiple doses of amphetamine (AMPH) for 2 days was evaluated. Neurodegeneration in rats that did not become hyperthermic during AMPH exposure was quantified by counting isolectin B4-labeled phagocytic microglia and Fluoro-Jade (F-J)-labeled neurons in the somatosensory parietal cortex, piriform cortex and posterolateral cortical amygdaloid nucleus (PLCo). The NMDA receptor antagonist, dizocilpine (0.63 mg/kg day) blocked AMPH-induced neurodegeneration in the somatosensory cortex. However, it did not affect degeneration in the piriform cortex and PLCo indicating that limbic degeneration was not NMDA-mediated. The dopamine antagonists, eticlopride (D2/3, 0.25 mg/kg day) and SCH-23390 (D1, 0.25 mg/kg day), blocked the stereotypic behavior and neurodegeneration in the somatosensory cortex. However, eticlopride had a lesser protective effect in the limbic regions. As well, the dopamine D2/D3 agonist quinpirole (1.5 mg/kg day) protected against cortical neurodegeneration when it was given during AMPH exposure and continued until sacrifice. The dopamine D1 agonist (SKF-38393, 12.5 mg/kg day) had no significant effect on neurodegeneration. These data indicate that there are significant differences in NMDA and dopamine D2 modulation of AMPH-induced neurodegeneration in the somatosensory cortex compared to the limbic cortices, and limbic cortical degeneration is not necessarily dependent on excessive stimulation of NMDA receptors as it is in the somatosensory cortex. Although excessive dopamine receptor stimulation during amphetamine exposure may trigger the neurodegenerative processes, continued D2 stimulation after AMPH exposure is neuroprotective in the cortex. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOPAMINE
KW - NEUROTRANSMITTERS
KW - CATECHOLAMINES
KW - EUGENICS
KW - AMPH, d-amphetamine
KW - Amphetamine
KW - ANOVA, analysis of variance
KW - Cortical amygdaloid nucleus
KW - CPu, caudate/putamen
KW - Dopamine receptor
KW - F-J, Fluoro-Jade
KW - GABA, gamma-amino-butyric acid
KW - GFAP, glial fibrillary acidic protein
KW - Limbic Cortex
KW - MBTOT, mean body temperature over time
KW - METH, methamphetamine
KW - Neurotoxicity
KW - NMDA receptor
KW - NMDA, N-methyl-d-aspartate
KW - Piriform cortex
KW - PLCo, posterolateral cortical amygdaloid nucleus
KW - REGWQ, Ryan–Eniot–Gabriel–Welsch
KW - Somatosensory cortex
N1 - Accession Number: 15552576; Bowyer, John F. 1; Email Address: jbowyer@nctr.fda.gov Delongchamp, Robert R. 2 Jakab, Robert L. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, United States 2: Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079, United States; Source Info: Dec2004, Vol. 1030 Issue 2, p234; Subject Term: DOPAMINE; Subject Term: NEUROTRANSMITTERS; Subject Term: CATECHOLAMINES; Subject Term: EUGENICS; Author-Supplied Keyword: AMPH, d-amphetamine; Author-Supplied Keyword: Amphetamine; Author-Supplied Keyword: ANOVA, analysis of variance; Author-Supplied Keyword: Cortical amygdaloid nucleus; Author-Supplied Keyword: CPu, caudate/putamen; Author-Supplied Keyword: Dopamine receptor; Author-Supplied Keyword: F-J, Fluoro-Jade; Author-Supplied Keyword: GABA, gamma-amino-butyric acid; Author-Supplied Keyword: GFAP, glial fibrillary acidic protein; Author-Supplied Keyword: Limbic Cortex; Author-Supplied Keyword: MBTOT, mean body temperature over time; Author-Supplied Keyword: METH, methamphetamine; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: NMDA receptor; Author-Supplied Keyword: NMDA, N-methyl-d-aspartate; Author-Supplied Keyword: Piriform cortex; Author-Supplied Keyword: PLCo, posterolateral cortical amygdaloid nucleus; Author-Supplied Keyword: REGWQ, Ryan–Eniot–Gabriel–Welsch; Author-Supplied Keyword: Somatosensory cortex; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.brainres.2004.10.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15552576&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - Gen
ID - 9999-20101-000
AN - 9999-20101-000
AU - DeSena, Allen D.
AU - Murphy, Robert A.
AU - Douglas-Palumberi, Heather
AU - Blau, Gary
AU - Kelly, Blandina
AU - Horwitz, Sarah M.
AU - Kaufman, Joan
T1 - Child Maltreatment Risk Assessment Checklist
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2005///
AD - Kaufman, Joan, Yale University, Department of Psychiatry, Congress Place, 301 Cedar St., PO Box 208098, New Haven, Connecticut, United States, 06520
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-20101-000. Partial author list: First Author & Affiliation: DeSena, Allen D.; Yale University, Department of Psychiatry, Child and Adolescent Research and Education (CARE) Program, New Haven, Connecticut, United States. Release Date: 20130408. Correction Date: 20151207. Instrument Type: Checklist. Test Location: Text, Page 633. Test Format: The items are rated as present or not present.. Language: English. Constructs: Child Maltreatment Risk Factors; Classification: Family Relationships and Parenting (6100). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180).
AB - Purpose: The purpose of this checklist is to measure risk factors for child maltreatment.
AB - Description: A Child Maltreatment Risk Assessment Checklist was developed by DeSena et al. (2005) in a study examining a group home permanency planning program (SAFE Homes) for children in out-of-home care. The checklist was used for each substantiated report of maltreatment. The 11 items, rated present or not present, included, for example, 'primary caretaker has previously had a child removed from care due to abuse or neglect' and 'caretaker does not take responsibility for the protection of the child.' The risk factors were used in generating propensity scores for matching subjects who received SAFE Home services with those in foster care. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Child Maltreatment Risk Assessment Checklist
KW - Test Development
KW - Child Welfare Services
U5 - Child Maltreatment Risk Assessment Checklist [Test Development]SAFE Homes: Is it worth the cost? An evaluation of a group home permanency planning program for children who first enter out-of-home care. (AN: 2005-08312-002 from PsycINFO) DeSena, Allen D.; Murphy, Robert A.; Douglas-Palumberi, Heather; Blau, Gary; Kelly, Blandina; Horwitz, Sarah M.; Kaufman, Joan; Jun, 2005. Source: Child Abuse & Neglect. 29(6), Elsevier Science, Netherlands; Jun, 2005; Age Group: Childhood (birth-12 yrs), Preschool Age (2-5 yrs), School Age (6-12 yrs); Population: Human; Male; Female; Age Range: 3-12 Yrs; Location: United States; Sample: Children Receiving SAFE Home Services and Foster Care Services Keywords: Child Maltreatment Risk Assessment Checklist; Test Development; Child Welfare Services; Subjects: Checklist (Testing); Child Abuse; Child Welfare; Foster Care; Risk Assessment; Test Construction;
DO - 10.1037/t20101-000
L3 - Full; Full text; 999920101_full_001.pdf
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UR - joan.kaufman@yale.edu
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 106391591
T1 - Delayed or forgone care among children with special health care needs: an analysis of the 2001 National Survey of Children with Special Health Care Needs.
AU - Huang ZJ
AU - Kogan MD
AU - Yu SM
AU - Strickland B
Y1 - 2005/01//Jan/Feb2005
N1 - Accession Number: 106391591. Language: English. Entry Date: 20060203. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101089367.
KW - Child Health Services -- Utilization
KW - Child, Medically Fragile
KW - Adolescence
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Female
KW - Health Services Accessibility
KW - Infant
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Multivariate Analysis
KW - Odds Ratio
KW - Questionnaires
KW - Random Sample
KW - Socioeconomic Factors
KW - Time Factors
KW - United States
KW - Human
SP - 60
EP - 67
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 5
IS - 1
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To examine the associations of sociodemographic characteristics with both the prevalence and the causes of delayed or forgone care in a nationally representative sample of children with special health care needs. METHODS: Data were abstracted from the 2001 National Survey of Children with Special Health Care Needs. The families of children with special health care needs (CSHCN) who reported delayed or forgone care were asked about the reasons. The 12 reasons in the questionnaire were grouped into 5 categories. Bivariate and multivariate logistic regression analyses were conducted in SUDAAN to examine the relationship between sociodemographic characteristics of CSHCN and the incidence of delayed or forgone care by its reasons. RESULTS: Nearly 10% of CSHCN had experienced delayed or forgone health care in the past 12 months in 2001. Logistic regression showed that delayed or forgone care was more likely to be reported by the families of CSHCN who were adolescents, who had more severe limitations, lived in the South or West, lacked medical insurance, and who lived in families under or near the federal poverty line. Hispanics were more likely to report 'lack of medical specialty' and 'had language, communication, or cultural problems with provider.' Both Hispanics and non-Hispanic others were twice as likely to report 'provider not accessible' as reasons for the delayed or forgone care compared with non-Hispanic whites or blacks. conclusion: CSHCN with certain socioeconomic status and sociodemographic characteristics, as well as those with severe limitations in activity, were more likely to be affected by circumstances that result in delayed or forgone care.
SN - 1530-1567
AD - Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Ln 18-44, Rockville, MD 20857; jhuang@hrsa.gov
U2 - PMID: 15656708.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Macher, Abe
T1 - Issues in Correctional HIV Care: Treatment of Tuberculosis.
JO - American Jails
JF - American Jails
Y1 - 2005/01//Jan/Feb2005
VL - 18
IS - 6
M3 - Article
SP - 25
EP - 28
SN - 10560319
AB - Discusses specific treatment considerations for patients with HIV-infection and tuberculosis (TB) in the U.S. Total number of TB cases in the country; Use of antiretroviral drugs in patients with concomitant TB; Association of all antiretroviral drugs with the potential for hepatotoxicity.
KW - HIV infections
KW - MEDICAL care
KW - TUBERCULOSIS
KW - THERAPEUTICS
KW - ANTIRETROVIRAL agents
KW - HEPATOTOXICOLOGY
KW - UNITED States
N1 - Accession Number: 16090162; Macher, Abe 1; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland; Source Info: Jan/Feb2005, Vol. 18 Issue 6, p25; Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: TUBERCULOSIS; Subject Term: THERAPEUTICS; Subject Term: ANTIRETROVIRAL agents; Subject Term: HEPATOTOXICOLOGY; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calci, Kevin R.
AU - Meade, Gloria K.
AU - Tezloff, Robert C.
AU - Kingsley, David H.
T1 - High-Pressure Inactivation of Hepatitis A Virus within Oysters.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2005/01//
VL - 71
IS - 1
M3 - Article
SP - 339
EP - 343
SN - 00992240
AB - Previous results demonstrated that hepatitis A virus (HAV) could be inactivated by high hydrostatic pressure (HHP) (D. H. Kingsley, D. Hoover, E. Papafragkou, and G. P. Richards, J. Food Prot. 65:1605-1609, 2002); however, direct evaluation of HAY inactivation within contaminated oysters was not performed. In this study, we report confirmation that HAV within contaminated shellfish is inactivated by HHP. Shellfish were initially contaminated with HAV by using a flowthrough system. PFU reductions of >1, >2, and >3 log10 were observed for 1-min treatments at 350, 375, and 400 megapascals, respectively, within a temperature range of 8.7 to 10.3°C. Bioconcentration of nearly 6 log10 PFU of HAV per oyster was achieved under simulated natural conditions. These results suggest that HHP treatment of raw shellfish will be a viable strategy for the reduction of infectious HAV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - OYSTERS -- Diseases
KW - HEPATITIS A
KW - HYDROSTATIC pressure
KW - SHELLFISH -- Microbiology
KW - MICROBIAL contamination
N1 - Accession Number: 17207061; Calci, Kevin R. 1 Meade, Gloria K. 2 Tezloff, Robert C. 3 Kingsley, David H. 2; Email Address: dkingsle@desu.edu; Affiliation: 1: Gulf Coast Seafood Laboratory, U S. Food and Drug Administration, Dauphin Island, Alabama 2: Microbial Food Safety Research Unit, W. W. Baker Center, Agricultural Research Service, U. S. Department of Agriculture, Delaware State University, Dover, Delaware 3: National Center for Food Safety and Technology, U S. Food and Drug Administration, Summit-Argo, Illinois; Source Info: Jan2005, Vol. 71 Issue 1, p339; Subject Term: HEPATITIS A virus; Subject Term: OYSTERS -- Diseases; Subject Term: HEPATITIS A; Subject Term: HYDROSTATIC pressure; Subject Term: SHELLFISH -- Microbiology; Subject Term: MICROBIAL contamination; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.71.1.339-343.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murphy, Dianne
T1 - Pediatric Trials: The Impact of U.S. Legislative and Regulatory Efforts.
JO - Applied Clinical Trials
JF - Applied Clinical Trials
Y1 - 2005/01//
VL - 14
IS - 1
M3 - Article
SP - 38
EP - 42
PB - Advanstar Communications Inc.
SN - 10648542
AB - Reports on the impact of legislative and regulatory efforts on pediatric trials in the U.S. Implications for the production and regulation of drug labeling; Globalized pediatic safety and efficacy trials.
KW - CLINICAL trials
KW - CHILDREN
KW - DRUGS
KW - MEDICAL policy
KW - LABELING
KW - UNITED States
N1 - Accession Number: 15622298; Murphy, Dianne 1; Affiliation: 1: Director, Office of Pediatric Therapeutics, U.S. Food and Drug Administration, 5600 Fishers Lane, Room 4B-44, Rockville, MD 20857; Source Info: Jan2005, Vol. 14 Issue 1, p38; Subject Term: CLINICAL trials; Subject Term: CHILDREN; Subject Term: DRUGS; Subject Term: MEDICAL policy; Subject Term: LABELING; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cerutti, Soledad
AU - Martinez, Luis D.
AU - Wuilloud, Rodolfo G.
T1 - Knotted Reactors and their Role in Flow- Injection On-line Preconcentration Systems Coupled to Atomic Spectrometry-Based Detectors.
JO - Applied Spectroscopy Reviews
JF - Applied Spectroscopy Reviews
Y1 - 2005/01//Jan-Mar2005
VL - 40
IS - 1
M3 - Article
SP - 71
EP - 101
SN - 05704928
AB - The progress in flow-injection (FI) on-line separation and preconcentration employing knotted reactors (KRs) as a sorption medium for organometallic complexes associated to atomic spectrometry techniques is reviewed in this article, focusing the attention on the more frequently complexing agents used. In the last years, the KR has demonstrated to be an excellent alternative in the FI on-line preconcentration procedures; the on-line preconcentration and separation of different metallic species on the inner walls of the KR have been developed utilizing diverse organic and inorganic reagents. The choice of complexing reagents, the coupling of the FI preconcentration system to atomic spectrometry techniques, and the application of the methodologies developed to different samples are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Spectroscopy Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR reactors
KW - FLOW injection analysis
KW - ATOMIC spectra
KW - NUCLEAR spectroscopy
KW - SPECTRUM analysis
KW - DETECTORS
KW - atomic spectrometry techniques
KW - flow-injection
KW - Knotted reactors
KW - preconcentration
N1 - Accession Number: 16133583; Cerutti, Soledad 1,2 Martinez, Luis D. 1,2; Email Address: ldm@unsl.edu.ar Wuilloud, Rodolfo G. 3; Affiliation: 1: Department of Analytical Chemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina 2: Consejo Nacional de Investigaciones Cientificas y Tećnicas (CONICET), Ciudad de Buenos Aires, Argentina 3: US Food and Drug Administration, Forensic Chimistry Center, Cincinnati, Ohio, USA; Source Info: Jan-Mar2005, Vol. 40 Issue 1, p71; Subject Term: NUCLEAR reactors; Subject Term: FLOW injection analysis; Subject Term: ATOMIC spectra; Subject Term: NUCLEAR spectroscopy; Subject Term: SPECTRUM analysis; Subject Term: DETECTORS; Author-Supplied Keyword: atomic spectrometry techniques; Author-Supplied Keyword: flow-injection; Author-Supplied Keyword: Knotted reactors; Author-Supplied Keyword: preconcentration; NAICS/Industry Codes: 332410 Power Boiler and Heat Exchanger Manufacturing; Number of Pages: 31p; Document Type: Article
L3 - 10.1081/LAPS38313
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - C.-H.-Lin
AU - Dunn, K. H.
AU - Horstman, R. H.
AU - Topmiller, J. L.
AU - Ahlers, M. F.
AU - Bennett, J. S.
AU - Sedgwick, L. M.
AU - Wirogo, S.
T1 - Numerical Simulation of Airflow and Airborne Pathogen Transport in Aircraft Cabins--Part I: Numerical Simulation of the Flow Field.
JO - ASHRAE Transactions
JF - ASHRAE Transactions
Y1 - 2005/01//
VL - 111
IS - 1
M3 - Article
SP - 755
EP - 763
PB - ASHRAE
SN - 00012505
AB - An initial study to develop a numerical tool using computational fluid dynamics (CFD) methods for investigating the potential of disease transmission in commercial aircraft is completed. To gain insight of the general airflow pattern, a detailed CFD model of a small section in the passenger cabin of a B767-300 passenger cabin was built and a Reynolds-averaged Navier-Stokes (RANS) simulation was performed. By comparing with the available test data, the RANS simulation substantially underpredicted the turbulence intensity, especially in and around the breathing zone. A .separate large eddy simulation (LES) was conducted to obtain a more realistic turbulent energy transport in a generic cabin model. The LES-predicted turbulence level is in fairly good agreement with the test data. Based on the LES results, the k and ε equations used in the RANS simulation were modified by using a special user subroutine. A RANS simulation with adjusted turbulence was then employed to simulate the dispersion of airborne pathogen in the detailed passenger cabin model. These adjustments allow for the simulation of disease transmission using less than 1/100 of the computing hardware resources required for an equivalent LES of airflow and particle transport. [ABSTRACT FROM AUTHOR]
AB - Copyright of ASHRAE Transactions is the property of ASHRAE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases -- Transmission
KW - AIR flow
KW - PATHOGENIC microorganisms
KW - FLUID dynamics
KW - AIRPLANES
KW - REYNOLDS number
KW - NAVIER-Stokes equations
KW - RESPIRATION
KW - TURBULENCE
N1 - Accession Number: 20295395; C.-H.-Lin 1 Dunn, K. H. 2 Horstman, R. H. 1 Topmiller, J. L. 2 Ahlers, M. F. 1 Bennett, J. S. 2 Sedgwick, L. M. 1 Wirogo, S. 3; Affiliation: 1: Boeing Commercial Airplanes Group, Seattle, Wash. 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Fluent, Inc., Lebanon, NH.; Source Info: 2005, Vol. 111 Issue 1, p755; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: AIR flow; Subject Term: PATHOGENIC microorganisms; Subject Term: FLUID dynamics; Subject Term: AIRPLANES; Subject Term: REYNOLDS number; Subject Term: NAVIER-Stokes equations; Subject Term: RESPIRATION; Subject Term: TURBULENCE; NAICS/Industry Codes: 336411 Aircraft Manufacturing; NAICS/Industry Codes: 336410 Aerospace product and parts manufacturing; Number of Pages: 9p; Illustrations: 5 Diagrams, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, C.-H.
AU - Dunn, K. H.
AU - Horstman, R. H.
AU - Topmiller, J. L.
AU - Ahlers, M. F.
AU - Bennett, J. S.
AU - Sedgwick, L. M.
AU - Wirogo, S.
T1 - Numerical Simulation of Airflow and Airborne Pathogen Transport in Aircraft Cabins--Part II: Numerical Simulation of Airborne Pathogen Transport.
JO - ASHRAE Transactions
JF - ASHRAE Transactions
Y1 - 2005/01//
VL - 111
IS - 1
M3 - Article
SP - 764
EP - 768
PB - ASHRAE
SN - 00012505
AB - There has been considerable public debate regarding airborne disease transmission in the passenger cabin of commercial aircraft. An initial study to develop a numerical tool, using computational fluid dynamics (CFD) methods, for investigating the potential of disease transmission in commercial aircraft, is completed and reported in this paper To gain insight of the general airflow pattern, a detailed CFD model of a section in the passenger cabin of a B767-300 passenger cabin was built and a Reynolds-averaged Navier-Stokes (RANS) simulation was performed. By comparison with the available test data, the RANS simulation substantially underpredicted the turbulence intensity, especially in and around the breathing zone (Lin et al. 2004). A separate large eddy simulation (LES) was conducted to obtain a more realistic turbulent energy transport in a generic cabin model. The LES-predicted turbulence level is in fairly good agreement with the test data, as reported separately in Lin et al. (2004). Based on the LES results, the k and e equations used in the RANS simulation were modified by using a special user subroutine. A RANS simulation with adjusted turbulence was then employed to simulate the dispersion of airborne pathogen in the detailed passenger cabin model. These adjustments allow for the simulation of disease transmission using less than I/WO the computing hardware resources required for an equivalent LES of airflow and particle transport. This paper is an elaboration on the numerical study of the transport of airborne pathogens in an aircraft cabin. [ABSTRACT FROM AUTHOR]
AB - Copyright of ASHRAE Transactions is the property of ASHRAE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases -- Transmission
KW - AIRBORNE infection
KW - FLUID dynamics
KW - FLUID mechanics
KW - AIRPLANES
KW - NAVIER-Stokes equations
KW - SIMULATION methods & models
KW - TURBULENCE
KW - PATHOGENIC microorganisms
N1 - Accession Number: 20295405; Lin, C.-H. 1 Dunn, K. H. 2 Horstman, R. H. 1 Topmiller, J. L. 2 Ahlers, M. F. 1 Bennett, J. S. 2 Sedgwick, L. M. 1 Wirogo, S. 3; Affiliation: 1: Boeing Commercial Airplanes Group, Seattle, Wash. 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Fluent, Inc., Lebanon, N.H.; Source Info: 2005, Vol. 111 Issue 1, p764; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: AIRBORNE infection; Subject Term: FLUID dynamics; Subject Term: FLUID mechanics; Subject Term: AIRPLANES; Subject Term: NAVIER-Stokes equations; Subject Term: SIMULATION methods & models; Subject Term: TURBULENCE; Subject Term: PATHOGENIC microorganisms; NAICS/Industry Codes: 336410 Aerospace product and parts manufacturing; NAICS/Industry Codes: 336411 Aircraft Manufacturing; Number of Pages: 5p; Illustrations: 7 Diagrams, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoffman, Richard M.
AU - Stone, S. Noell
AU - Espey, David
AU - Potosky, Arnold L.
T1 - Differences between men with screening-detected versus clinically diagnosed prostate cancers in the USA.
JO - BMC Cancer
JF - BMC Cancer
Y1 - 2005/01//
VL - 5
M3 - Article
SP - 27
EP - 9
PB - BioMed Central
SN - 14712407
AB - Background: The advent of prostate specific antigen (PSA) testing in the United States of America (USA) has led to a dramatic increase in the incidence of prostate cancer in the United States as well as the number of men undergoing aggressive treatment with radical prostatectomy and radiation therapy. We compared patient characteristics and treatment selection between American men with screening-detected versus clinically diagnosed prostate cancers. Methods: We evaluated 3,173 men with prostate cancer in the USA. Surveys and medical records provided information on demographics, socioeconomic status, comorbidities, symptoms, tumor characteristics, and treatment. We classified men presenting with symptoms of advanced cancer - bone pain, weight loss, or hematuria - as "clinically diagnosed"; asymptomatic men and those with only lower urinary tract symptoms were considered "screening-detected." We used multivariate analyses to determine whether screening predicted receiving aggressive treatment for a clinically localized cancer. Results: We classified 11% of cancers as being clinically diagnosed. Men with screening-detected cancers were more often non-Hispanic white (77% vs. 65%, P < 0.01), younger (36% < 65 years vs. 25%, P ≤ 0.01), better educated (80% = high school vs. 67%, P < 0.01), healthier (18% excellent health vs. 10%, P < 0.01), and diagnosed with localized disease (90% vs. 75%, P < 0.01). Men with screening-detected localized cancers more often underwent aggressive treatment, 76% vs. 70%, P = 0.05. Conclusion: Most cancers were detected by screening in this American cohort. Appropriately, younger, healthier men were more likely to be diagnosed by screening. Minority status and lower socio-economic status appeared to be screening barriers. Screening detected earlier-stage cancers and was associated with receiving aggressive treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE cancer
KW - CANCER treatment
KW - CANCER patients
KW - URINARY organs -- Diseases
KW - URINARY organs
KW - URINALYSIS
N1 - Accession Number: 31613916; Hoffman, Richard M. 1,2; Email Address: rhoffman@unm.edu Stone, S. Noell 2,3; Email Address: noells@nmtr.unm.edu Espey, David 4; Email Address: david.espey@ihs.gov Potosky, Arnold L. 5; Email Address: potoskya@mail.nih.gov; Affiliation: 1: Medicine Service, New Mexico VA Health Care System, Albuquerque, New Mexico, USA 2: New Mexico Tumor Registry, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA 3: Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK 4: CDC Division of Cancer Prevention and Control and Indian Health Service National Epidemiology Program, Albuquerque, New Mexico, USA 5: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA; Source Info: 2005, Vol. 5, p27; Subject Term: PROSTATE cancer; Subject Term: CANCER treatment; Subject Term: CANCER patients; Subject Term: URINARY organs -- Diseases; Subject Term: URINARY organs; Subject Term: URINALYSIS; Number of Pages: 9p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1186/1471-2407-5-27
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bhattacharya, Bhaskar
AU - Cai, Jingli
AU - Luo, Youngquan
AU - Miura, Takumi
AU - Mejido, Josef
AU - Brimble, Sandii N
AU - Zeng, Xianmin
AU - Schulz, Thomas C
AU - Rao, Mahendra S
AU - Puri, Raj K
T1 - Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies.
JO - BMC Developmental Biology
JF - BMC Developmental Biology
Y1 - 2005/01//
VL - 5
M3 - Article
SP - 22
EP - 16
PB - BioMed Central
SN - 1471213X
AB - Background: The identification of molecular pathways of differentiation of embryonic stem cells (hESC) is critical for the development of stem cell based medical therapies. In order to identify biomarkers and potential regulators of the process of differentiation, a high quality microarray containing 16,659 seventy base pair oligonucleotides was used to compare gene expression profiles of undifferentiated hESC lines and differentiating embryoid bodies. Results: Previously identified "stemness" genes in undifferentiated hESC lines showed down modulation in differentiated cells while expression of several genes was induced as cells differentiated. In addition, a subset of 194 genes showed overexpression of greater than ⩾ 3 folds in human embryoid bodies (hEB). These included 37 novel and 157 known genes. Gene expression was validated by a variety of techniques including another large scale array, reverse transcription polymerase chain reaction, focused cDNA microarrays, massively parallel signature sequencing (MPSS) analysis and immunocytochemisty. Several novel hEB specific expressed sequence tags (ESTs) were mapped to the human genome database and their expression profile characterized. A hierarchical clustering analysis clearly depicted a distinct difference in gene expression profile among undifferentiated and differentiated hESC and confirmed that microarray analysis could readily distinguish them. Conclusion: These results present a detailed characterization of a unique set of genes, which can be used to assess the hESC differentiation. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Developmental Biology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - EMBRYONIC stem cells
KW - EMBRYOS
KW - OLIGONUCLEOTIDES
KW - POLYMERASE chain reaction
N1 - Accession Number: 28808205; Bhattacharya, Bhaskar 1; Email Address: Bhattacharya@cber.fda.gov Cai, Jingli 2; Email Address: CaiJi@grc.nia.nih.gov Luo, Youngquan 2; Email Address: LuoYo@grc.nia.nih.gov Miura, Takumi 2; Email Address: miurat@grc.nia.nih.gov Mejido, Josef 1; Email Address: jmejido@niaid.nih.gov Brimble, Sandii N 3; Email Address: sbrimble@novocell.com Zeng, Xianmin 4; Email Address: Xzeng@intra.nida.nih.gov Schulz, Thomas C 3; Email Address: tjschulz@novocell.com Rao, Mahendra S 1,2; Email Address: raomah@grc.nia.nih.gov Puri, Raj K 1; Email Address: puri@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Laboratory of Neuroscience, National Institute on Aging, Baltimore, Maryland 21224, USA, 3: Bresagen Inc., Athens, GA, USA 4: National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 2005, Vol. 5, p22; Subject Term: GENE expression; Subject Term: EMBRYONIC stem cells; Subject Term: EMBRYOS; Subject Term: OLIGONUCLEOTIDES; Subject Term: POLYMERASE chain reaction; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 16p; Illustrations: 6 Black and White Photographs, 1 Diagram; Document Type: Article
L3 - 10.1186/1471-213X-5-22
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brazil, Kevin
AU - Ozer, Elizabeth
AU - Cloutier, Michelle M
AU - Levine, Robert
AU - Stryer, Daniel
T1 - From theory to practice: improving the impact of health services research.
JO - BMC Health Services Research
JF - BMC Health Services Research
Y1 - 2005/01//
VL - 5
M3 - Article
SP - 1
EP - 5
PB - BioMed Central
SN - 14726963
AB - Background: While significant strides have been made in health research, the incorporation of research evidence into healthcare decision-making has been marginal. The purpose of this paper is to provide an overview of how the utility of health services research can be improved through the use of theory. Integrating theory into health services research can improve research methodology and encourage stronger collaboration with decision-makers. Discussion: Recognizing the importance of theory calls for new expectations in the practice of health services research. These include: the formation of interdisciplinary research teams; broadening the training for those who will practice health services research; and supportive organizational conditions that promote collaboration between researchers and decision makers. Further, funding bodies can provide a significant role in guiding and supporting the use of theory in the practice of health services research. Summary: Institutions and researchers should incorporate the use of theory if health services research is to fulfill its potential for improving the delivery of health care. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Health Services Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health research
KW - DECISION making
KW - THEORY
KW - METHODOLOGY
KW - RESEARCH
KW - RESEARCH teams
N1 - Accession Number: 29324198; Brazil, Kevin 1; Email Address: brazilk@mcmaster.ca Ozer, Elizabeth 2; Email Address: eozer@itsa.ucsf.edu Cloutier, Michelle M 3; Email Address: mclouti@ccmckids.org Levine, Robert 4; Email Address: rlevine@mmc.edu Stryer, Daniel 5; Email Address: dstryer@AHRQ.gov; Affiliation: 1: Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University and St. Joseph's Health System Research Network, Hamilton, ON, Canada 2: Department of Pediatrics/Adolescent Medicine, University of California, San Francisco, CA, USA, 3: Department of Pediatrics, University of Connecticut Health Center and Connecticut. Children's Medical Center, Hartford, CT, USA, 4: Occupational and Preventive Medicine, Meharry Medical College, Nashville, TN, USA 5: Center for Outcomes and Effectiveness Research, Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: 2005, Vol. 5, p1; Subject Term: PUBLIC health research; Subject Term: DECISION making; Subject Term: THEORY; Subject Term: METHODOLOGY; Subject Term: RESEARCH; Subject Term: RESEARCH teams; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Document Type: Article
L3 - 10.1186/1472-6963-5-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atkins, David
AU - Briss, Peter A
AU - Eccles, Martin
AU - Flottorp, Signe
AU - Guyatt, Gordon H
AU - Harbour, Robin T
AU - Hill, Suzanne
AU - Jaeschke, Roman
AU - Liberati, Alessandro
AU - Magrini, Nicola
AU - Mason, James
AU - O'Connell, Dianne
AU - Oxman, Andrew D
AU - Phillips, Bob
AU - Schünemann, Holger
AU - Edejer, Tessa Tan-Torres
AU - Vist, Gunn E
AU - Williams Jr, John W
T1 - Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system.
JO - BMC Health Services Research
JF - BMC Health Services Research
Y1 - 2005/01//
VL - 5
M3 - Article
SP - 25
EP - 12
PB - BioMed Central
SN - 14726963
AB - Background: Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach to grading evidence and recommendations. Methods: A GRADE evidence profile consists of two tables: a quality assessment and a summary of findings. Twelve evidence profiles were used in this pilot study. Each evidence profile was made based on information available in a systematic review. Seventeen people were given instructions and independently graded the level of evidence and strength of recommendation for each of the 12 evidence profiles. For each example judgements were collected, summarised and discussed in the group with the aim of improving the proposed grading system. Kappas ere calculated as a measure of chance-corrected agreement for the quality of evidence for each outcome for each of the twelve evidence profiles. The seventeen judges were also asked about the ease of understanding and the sensibility of the approach. All of the judgements were recorded and disagreements discussed. Results: There was a varied amount of agreement on the quality of evidence for the outcomes relating to each of the twelve questions (kappa coefficients for agreement beyond chance ranged from 0 to 0.82). However, there was fair agreement about the relative importance of each outcome. There was poor agreement about the balance of benefits and harms and recommendations. Most of the disagreements were easily resolved through discussion. In general we found the GRADE approach to be clear, understandable and sensible. Some modifications were made in the approach and it was agreed that more information was needed in the evidence profiles. Conclusion: Judgements about evidence and recommendations are complex. Some subjectivity, especially regarding recommendations, is unavoidable. We believe our system for guiding these complex judgements appropriately balances the need for simplicity with the need for full and transparent consideration of all important issues. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Health Services Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMATIC reviews (Medical research)
KW - QUALITY
KW - EVIDENCE
KW - TESTING
KW - RECOMMENDER systems (Information filtering)
N1 - Accession Number: 29324222; Atkins, David 1; Email Address: DAtkins@AHRQ.GOV Briss, Peter A 2; Email Address: pxb5@cdc.gov; Eccles, Martin 3; Email Address: Martin.Eccles@newcastle.ac.uk Flottorp, Signe 4; Email Address: signe.flottorp@nhsrc.no Guyatt, Gordon H 5; Email Address: guyatt@mcmaster.ca Harbour, Robin T 6; Email Address: r.harbour@sign.ac.uk Hill, Suzanne 7; Email Address: hillsu@mail.newcastle.edu.au Jaeschke, Roman 8; Email Address: jaeschke@mcmaster.ca Liberati, Alessandro 9; Email Address: alesslib@tin.it Magrini, Nicola 10; Email Address: n.magrini@ausl.mo.it Mason, James 3; Email Address: jmason123@orange.ne O'Connell, Dianne 11; Email Address: dianneo@nswcc.org.au Oxman, Andrew D 4; Email Address: oxman@online.no Phillips, Bob 12; Email Address: bob.phillips@doctors.org.uk Schünemann, Holger 5,13; Email Address: hjs@buffalo.edu Edejer, Tessa Tan-Torres 14; Email Address: tantorrest@who.ch Vist, Gunn E 4; Email Address: gev@nhsrc.no Williams Jr, John W 15; Email Address: jw.williams@duke.edu; Affiliation: 1: Center for Practice and Technology Assessment, Agency for Healthcare Research and Quality, 540 Gaither Rd. Rokville, MD 20852, USA 2: Community Guide Branch, Centers for Disease Control and Prevention, MS K73, 4770 Buford Highway, Atlanta, GA 30341, USA 3: Centre for Health Services Research, University of Newcastle upon Tyne, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, UK 4: Informed Choice Research Department, Norwegian Health Services Research Centre, Pb. 7004 St. Olavs Plass, 0130 Oslo, Norway 5: Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada 6: Scottish Intercollegiate Guidelines Network, 9 Queen Street, Edinburgh EH2 1JQ, UK 7: Department of Clinical Pharmacology, Faculty of Medicine and Health Sciences, University of Newcastle, Level 5, New Med 2 Building, Newcastle Mater Hospital, Waratah, NSW 2298, Australia 8: Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada 9: Department of Oncology and Hematology, Universita di Modena e Reggio Emilia, Azienda Ospedaliera Policlinico, Via dal Pozzo 41, 41100 Modena, Italia and Centro per la Valutazione della Efficacia della Assistenza Sanitaria (CeVEAS), Modena, Italy 10: Centro per la Valutazione della Efficacia della Assistenza Sanitaria (CeVEAS), NHS Centre for the Evaluation of the Effectiveness of Health Care, Viale Muratori 201, Modena 41100, Italy 11: Cancer Epidemiology Research Unit, Cancer Research and Registers Division, The Cancer Council NSW, PO Box 572, Kings Cross NSW 1340, Australia 12: Centre for Evidence-based Medicine, University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK 13: Departments of Medicine and Social & Preventive Medicine, University at Buffalo, State University of New York, ECMC-CC142, 462 Grider St, Buffalo, NY 14215, USA 14: Global Programme on Evidence for Health Policy, World Health Organisation, CH-1211 Geneva 27, Switzerland 15: The Center for Health Services Research in Primary Care, HSR&D, Department of Veterans Affairs Medical Center and Duke University Medical Center, 508 Fulton St., Durham, NC 27705, USA; Source Info: 2005, Vol. 5, p25; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: QUALITY; Subject Term: EVIDENCE; Subject Term: TESTING; Subject Term: RECOMMENDER systems (Information filtering); Number of Pages: 12p; Illustrations: 11 Charts; Document Type: Article
L3 - 10.1186/1472-6963-5-25
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van Loock, Marnix
AU - Verminnen, Kristel
AU - Messmer, Trudy O.
AU - Volckaert, Guido
AU - Goddeeris, Bruno M.
AU - Vanrompay, Daisy
T1 - Use of a nested PCR-enzyme immunoassay with an internal control to detect Chlamydophila psittaci in turkeys.
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
Y1 - 2005/01//
VL - 5
IS - 1
M3 - Article
SP - 1
EP - 9
PB - BioMed Central
SN - 14712334
AB - Background: Laboratory diagnosis of Chlamydophila psittaci, an important turkey respiratory pathogen, is difficult. To facilitate the diagnosis, a nested PCR-enzyme immunoassay (PCR-EIA) was developed to detect the Cp. psittaci outer membrane protein A (ompA) gene in pharyngeal swabs. Methods: The fluorescein-biotin labelled PCR products were immobilized on streptavidin-coated microtiter plates and detected with anti-fluorescein peroxidase conjugate and a colorimetric substrate. An internal inhibition control was included to rule out the presence of inhibitors of DNA amplification. The diagnostic value of the ompA nested PCR-EIA in comparison to cell culture and a 16S-rRNA based nested PCR was assessed in pharyngeal turkey swabs from 10 different farms experiencing respiratory disease. Results: The sensitivity of the nested PCR-EIA was established at 0.1 infection forming units (IFU). Specificity was 100%. The ompA nested PCR-EIA was more sensitive than the 16S-rRNA based nested PCR and isolation, revealing 105 out of 200 (52.5%) positives against 13 and 74 for the latter two tests, respectively. Twenty-nine (23.8%) out of 122 ompA PCR-EIA negatives showed the presence of inhibitors of DNA amplification, although 27 of them became positive after diluting (1/10) the specimens in PCR buffer or after phenol-chloroform extraction and subsequent ethanol precipitation. Conclusion: The present study stresses the need for an internal control to confirm PCR truenegatives and demonstrates the high prevalence of chlamydiosis in Belgian turkeys and its potential zoonotic risk. The ompA nested PCR- EIA described here is a rapid, highly sensitive and specific diagnostic assay and will help to facilitate the diagnosis of Cp. psittaci infections in both poultry and man. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Infectious Diseases is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEMBRANE proteins
KW - POLYMERASE chain reaction
KW - ENZYME-linked immunosorbent assay
KW - CHLAMYDOPHILA infections
KW - TURKEYS
KW - DISEASES
KW - FLUORESCEIN
N1 - Accession Number: 28796231; Van Loock, Marnix 1; Email Address: marnix.van.loock@pandora.be Verminnen, Kristel 2; Email Address: Kristel.Verminnen@UGent.be Messmer, Trudy O. 3; Email Address: TMessmer@cdc.gov Volckaert, Guido 1; Email Address: Guido.Volckaert@biw.kuleuven.be Goddeeris, Bruno M. 1,4; Email Address: Bruno.Goddeeris@biw.kuleuven.be Vanrompay, Daisy 2; Email Address: Daisy.Vanrompay@UGent.be; Affiliation: 1: Department of Biosystems, Catholic University of Leuven, Kasteelpark Arenberg 30, 3001 Heverlee, Belgium 2: Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium 3: Department of Health and Human Services, National Center for Infectious Diseases, Centres for Disease Control and Prevention, Public Health Service, Atlanta, Georgia 30333, USA 4: Department of Virology, Parasitology and Immunology, Ghent University, Salisburylaan 133, 9820 Merelbeke; Belgium; Source Info: 2005, Vol. 5 Issue 1, p1; Subject Term: MEMBRANE proteins; Subject Term: POLYMERASE chain reaction; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: CHLAMYDOPHILA infections; Subject Term: TURKEYS; Subject Term: DISEASES; Subject Term: FLUORESCEIN; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112330 Turkey Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; Number of Pages: 9p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1186/1471-2334-5-76
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Watson, John T.
AU - Jones, Roderick C.
AU - Siston, Alicia M.
AU - Diaz, Pamela S.
AU - Gerber, Susan I.
AU - Crowe, John B.
AU - Satzger, Duane
T1 - Outbreak of Food-borne Illness Associated with Plant Material Containing Raphides.
JO - Clinical Toxicology (15563650)
JF - Clinical Toxicology (15563650)
Y1 - 2005/01//
VL - 43
IS - 1
M3 - Article
SP - 17
EP - 21
PB - Taylor & Francis Ltd
SN - 15563650
AB - Background. Many botanicals, particularly ornamental houseplants, contain crystals of calcium oxalate called raphides. Raphides have known toxic effects when chewed, including painful edema, vesicle formation, and dysphagia. We report a food-borne illness outbreak associated with ingestion of raphides. Methods. On February 24, 2003, the Chicago Department of Public Health was notified of multiple cases of oral burning and facial edema associated with lunch in an office cafeteria on February 21. The investigation included a case-control study, interviews with kitchen staff, an environmental inspection, and laboratory analysis of leftover foods. Results. Ten cases were identified, including one admitted to the Intensive Care Unit for potential airway obstruction secondary to severe edema, and another seen by Emergency Department staff for oral edema and pain. Ten of 10 case-patients reported oral stinging and burning, and 8 of 10 reported dysphagia. Four of 10 case-patients continued to have symptoms 2 weeks later. Food from the cafeteria's international buffet was consumed by 10 of 10 case-patients and by 1 of 22 control subjects (odds ratio = undefined); each of the 10 case-patients reported consumption of a Chinese vegetable entrée from the international buffet and had no other foods in common. Plant material from the Chinese vegetable entrée contained raphides. Conclusion. This outbreak was associated with consumption of raphides resembling those from common botanicals. Clinicians and public health practitioners should be aware of raphide-containing plants as a potential cause of food-borne illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Toxicology (15563650) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOODBORNE diseases
KW - RAPHIDES
KW - PLANTS
KW - TOXICOLOGY
KW - EDEMA
KW - DEGLUTITION disorders
KW - Araceae
KW - Calcium oxalate
KW - Disease outbreaks
KW - Food poisoning
KW - Toxic plants
N1 - Accession Number: 16237232; Watson, John T. 1,2; Email Address: watson_john@cdph.org Jones, Roderick C. 2 Siston, Alicia M. 2 Diaz, Pamela S. 2 Gerber, Susan I. 2 Crowe, John B. 3 Satzger, Duane 3; Affiliation: 1: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA 2: Chicago Department of Public Health, Chicago, Illinois, USA 3: Forensic Chemistry Center, Food and Drug Administration, Cincinnati, Ohio, USA; Source Info: Jan2005, Vol. 43 Issue 1, p17; Subject Term: FOODBORNE diseases; Subject Term: RAPHIDES; Subject Term: PLANTS; Subject Term: TOXICOLOGY; Subject Term: EDEMA; Subject Term: DEGLUTITION disorders; Author-Supplied Keyword: Araceae; Author-Supplied Keyword: Calcium oxalate; Author-Supplied Keyword: Disease outbreaks; Author-Supplied Keyword: Food poisoning; Author-Supplied Keyword: Toxic plants; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1081/CLT-200044721
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16237232&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barczak, Thomas M.
AU - Tadolini, Stephen C.
AU - McKelvey, Paul
T1 - Hydraulic Prestressing Units: An Innovation In Roof Support Technology.
JO - Coal International
JF - Coal International
Y1 - 2005/01//Jan/Feb2005
VL - 253
IS - 1
M3 - Article
SP - 16
EP - 26
PB - Tradelink Publications Ltd.
SN - 13576941
AB - Examines the performance capabilities of a mine roof support technology, hydraulic prestressing units and their applications in U.S. coal mines. Advantages hydraulic prestressing over passive mine roof support system; Historical overview of prestressing systems; Issues concerning ground control performance of PSU; Installation procedures of PSU.
KW - COAL mines & mining
KW - MINING engineering
KW - MINE roof control
KW - HYDRAULIC mining
KW - EQUIPMENT & supplies
KW - GROUND control (Mining)
KW - COAL mining machinery
KW - UNITED States
N1 - Accession Number: 16182548; Barczak, Thomas M. 1; Tadolini, Stephen C. 2; McKelvey, Paul 3; Affiliations: 1: Research Geophysicist, Geotechnical Engineering National Institute for Occupational Safety and Health Pittsburgh Research Laboratory Pittsburgh, Pennsylvania USA; 2: Section Chief, Geotechnical Engineering National Institute for Occupational Safety and Health Pittsburgh Research Laboratory Pittsburgh, Pennsylvania USA; 3: Director-AMSS, New Concept Mining Johannesburg, South Africa; Issue Info: Jan/Feb2005, Vol. 253 Issue 1, p16; Thesaurus Term: COAL mines & mining; Thesaurus Term: MINING engineering; Subject Term: MINE roof control; Subject Term: HYDRAULIC mining; Subject Term: EQUIPMENT & supplies; Subject Term: GROUND control (Mining); Subject Term: COAL mining machinery; Subject: UNITED States; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 212220 Gold and silver ore mining; NAICS/Industry Codes: 541330 Engineering Services; Number of Pages: 9p; Illustrations: 12 Color Photographs, 1 Black and White Photograph, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106487138
T1 - Co-occurrence of DSM-IV personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
AU - Grant BF
AU - Stinson FS
AU - Dawson DA
AU - Chou SP
AU - Ruan WJ
Y1 - 2005/01//Jan/Feb2005
N1 - Accession Number: 106487138. Language: English. Entry Date: 20050715. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Short Form 12 Health Survey (SF-12); Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV version (AUDADIS-IV). NLM UID: 0372612.
KW - Comorbidity
KW - Personality Disorders -- Epidemiology
KW - Adult
KW - Data Analysis Software
KW - DSM
KW - Epidemiological Research
KW - Interrater Reliability
KW - Interview Guides
KW - Kappa Statistic
KW - Linear Regression
KW - Odds Ratio
KW - Personality Disorders -- Classification
KW - Personality Disorders -- Diagnosis
KW - Psychological Tests
KW - Questionnaires
KW - Semi-Structured Interview
KW - Surveys
KW - Test-Retest Reliability
KW - United States
KW - Human
SP - 1
EP - 5
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
JA - COMPR PSYCHIATRY
VL - 46
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0010-440X
AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304; bgrant@willco.niaaa.nih.gov
U2 - PMID: 15714187.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106487138&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kennet, Joel
AU - Aldworth, Jeremy
AU - Painter, Dicy
AU - Barker, Peggy
T1 - Applying Cognitive Psychological Principles to the Improvement of Survey Data: A Case Study from the National Survey on Drug Use and Health.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2005/01//
M3 - Article
SP - 1
KW - expert review
KW - questionnaire design
KW - response process..PAT.-Conference Proceeding
N1 - Accession Number: 26606887; Kennet, Joel 1; Email Address: joel.kennet@samhsa.hhs.gov Aldworth, Jeremy 2; Email Address: jaldworth@rti.org Painter, Dicy 1; Email Address: dicy.painter@samhsa.hhs.gov Barker, Peggy 1; Email Address: peggy.barker@samhsa.hhs.gov; Affiliation: 1: Substance Abuse and Mental Health Services Administration 2: RTI International; Source Info: 2005, p1; Author-Supplied Keyword: expert review; Author-Supplied Keyword: questionnaire design; Author-Supplied Keyword: response process..PAT.-Conference Proceeding; Number of Pages: 0p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kennet, Joel
AU - Murphy, Joseph
AU - Cunningham, David
AU - Flicker, Laura
AU - Aldworth, Jeremy
AU - Myers, Susan
T1 - Incidence and Impact of Controlled Access Situations on Unit Nonresponse.
JO - Conference Papers -- American Association for Public Opinion Research
JF - Conference Papers -- American Association for Public Opinion Research
Y1 - 2005/01//
M3 - Article
SP - 1
KW - controlled access
KW - limited access
KW - nonresponse..PAT.-Conference Proceeding
N1 - Accession Number: 26607000; Kennet, Joel 1; Email Address: joel.kennet@samhsa.hhs.gov Murphy, Joseph 2; Email Address: jmurphy@rti.org Cunningham, David 2; Email Address: dbc@rti.org Flicker, Laura 2; Email Address: lflicker@rti.org Aldworth, Jeremy 2; Email Address: jaldworth@rti.org Myers, Susan 2; Email Address: smyers@rti.org; Affiliation: 1: Substance Abuse and Mental Health Services Administration 2: RTI International; Source Info: 2005, p1; Author-Supplied Keyword: controlled access; Author-Supplied Keyword: limited access; Author-Supplied Keyword: nonresponse..PAT.-Conference Proceeding; Number of Pages: 0p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26607000&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Farquhar, Marybeth
T1 - New Governance in Hospital Quality Improvement:.
JO - Conference Papers -- Law & Society
JF - Conference Papers -- Law & Society
Y1 - 2005///2005 Annual Meeting
M3 - Article
SP - 1
AB - Across the nation, many Americans are provided with high quality services that either maintain or restore health. Yet concern has surfaced about the quality of care being delivered by the healthcare sector. While there are many systems that can measure, track, and report on the quality of care delivered in the United States, there is no national comprehensive system that can provide this information to the public. In 2002, the American Hospital Association (AHA), the Federation of American Hospitals (FAH), and American Association of Medical Colleges (AAMC) announced the formation of the Quality Initiative(now known as the Hospital Quality Alliance), a public-private partnership that will work together to standardize and to voluntary report hospital quality indicators to the public. Therefore, the purpose of this paper is to explore the origins of this collaborative, and report on its progress thus far. In particular to look at those aspects that influenced the development of the collaborative as well as those factors that predisposed the Centers for Medicare & Medicaid Services (CMS) current decision to enter into a public-private partnership with the hospital industry. ..PAT.-Conference Proceeding [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- Law & Society is the property of Law & Society Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - PARTNERSHIP (Business)
KW - MEDICARE
KW - HOSPITAL administration
KW - AMERICAN Hospital Association
N1 - Accession Number: 27211471; Farquhar, Marybeth 1; Email Address: mfarquha@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: 2005 Annual Meeting, p1; Subject Term: HEALTH; Subject Term: PARTNERSHIP (Business); Subject Term: MEDICARE; Subject Term: HOSPITAL administration; Company/Entity: AMERICAN Hospital Association DUNS Number: 051064566; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 0p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shukla, H. D.
AU - Sharma, S. K.
T1 - Clostridium botulinum: A Bug with Beauty and Weapon.
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
Y1 - 2005/01//Jan-Mar2005
VL - 31
IS - 1
M3 - Article
SP - 11
EP - 18
PB - Taylor & Francis Ltd
SN - 1040841X
AB - Clostridium botulinum, a Gram-positive, anaerobic sporeforming bacteria, is distinguished by its significant clinical applications as well as its potential to be used as bioterror agent. Growing cells secrete botulinum neurotoxin (BoNT), the most poisonous of all known poisons. While BoNT is the causative agent of deadly neuroparalytic botulism, it also serves as a remarkably effective treatment for involuntary muscle disorders such as blepharospasm, strabismus, hemifacial spasm, certain types of spasticity in children, and other ailments. BoNT is also used in cosmetology for the treatment of glabellar lines, and is well-known as the active component of the anti-aging medications Botox® and Dysport®. In addition, recent reports show that botulinum neurotoxin can be used as a tool for pharmaceutical drug delivery. However, BoNT remains the deadliest of all toxins, and is viewed by biodefense researchers as a possible agent of bioterrorism (BT). Among seven serotypes, C. botulinum type A is responsible for the highest mortality rate in botulism, and thus has the greatest potential to act as biological weapon. Genome sequencing of C. botulinum type A Hall strain (ATCC 3502) is now complete, and has shown the genome size to be 3.89 Mb with a G+C content of approximately 28.2%. The bacterium harbors a 16.3 kb plasmid with a 26.8% G+C content—slightly lower than that of the chromosome. Most of the virulence factors in C. botulinum are chromosomally encoded; bioinformatic analysis of the genome sequence has shown that the plasmid does not harbor toxin genes or genes for related virulence factors. Interestingly, the plasmid does harbor genes essential to replication, including dnaE, which encodes the alpha subunit of DNA polymerase III which has close similarity with its counterpart in C. perfringens strain 13. The plasmid also contains similar genes to those that encode the ABC-type multidrug transport ATPase, and permease. The presence of ABC-type multidrug transport ATPase, and permease suggests putative involvement of efflux pumps in bacteriocin production, modification, and export in C. botulinum. The C. botulinum plasmid additionally harbors genes for LambdaBa04 prophage and site-specific recombinase that are similar to those found in the Ames strain of Bacillus anthracis; these genes and their products may play a role in genomic rearrangement. Completion of genome sequencing for C. botulinum will provide an opportunity to design genomic and proteomic-based systems for detecting different serotypes of C. botulinum strains in the environment. The completed sequence may also facilitate identification of potential virulence factors and drug targets, as well as help characterize neurotoxin-complexing proteins, their polycistronic expression, and phylogenetic relationships between different serotypes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Microbiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetics
KW - Hazardous substances
KW - Botulinum toxin
KW - Clostridium diseases
KW - Bacillus (Bacteria)
KW - DNA polymerases
KW - Bioweapon
KW - Botulism
KW - C. botulinum
KW - Genome
KW - Neurotransmitter
N1 - Accession Number: 16358279; Shukla, H. D. 1; Email Address: shukla@umbi.umd.edu; Sharma, S. K. 2; Affiliations: 1: Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA.; 2: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA.; Issue Info: Jan-Mar2005, Vol. 31 Issue 1, p11; Thesaurus Term: Genetics; Thesaurus Term: Hazardous substances; Subject Term: Botulinum toxin; Subject Term: Clostridium diseases; Subject Term: Bacillus (Bacteria); Subject Term: DNA polymerases; Author-Supplied Keyword: Bioweapon; Author-Supplied Keyword: Botulism; Author-Supplied Keyword: C. botulinum; Author-Supplied Keyword: Genome; Author-Supplied Keyword: Neurotransmitter; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10408410590912952
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16358279&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tournas, V. H.
T1 - Spoilage of Vegetable Crops by Bacteria and Fungi and Related Health Hazards.
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
Y1 - 2005/01//Jan-Mar2005
VL - 31
IS - 1
M3 - Article
SP - 33
EP - 44
PB - Taylor & Francis Ltd
SN - 1040841X
AB - After harvest, vegetables are often spoiled by a wide variety of microorganisms including many bacterial and fungal species. The most common bacterial agents are Erwinia carotovora, Pseudomonas spp., Corynebacterium, Xanthomonas campestris, and lactic acid bacteria with E. carotovora being the most common, attacking virtually every vegetable type. Fungi commonly causing spoilage of fresh vegetables are Botrytis cinerea, various species of the genera Alternaria, Aspergillus, Cladosporium, Colletotrichum, Phomopsis, Fusarium, Penicillium, Phoma, Phytophthora, Pythium and Rhizopus spp., Botrytis cinerea, Ceratocystis fimbriata, Rhizoctonia solani, Sclerotinia sclerotiorum, and some mildews. A few of these organisms show a substrate preference whereas others such as Botrytis cinerea, Colletotrichum, Alternaria, Cladosporium, Phytophthora, and Rhizopus spp., affect a wide variety of vegetables causing devastating losses. Many of these agents enter the plant tissue through mechanical or chilling injuries, or after the skin barrier has been broken down by other organisms. Besides causing huge economic losses, some fungal species could produce toxic metabolites in the affected sites, constituting a potential health hazard for humans. Additionally, vegetables have often served as vehicles for pathogenic bacteria, viruses, and parasites and were implicated in many food borne illness outbreaks. In order to slow down vegetable spoilage and minimize the associated adverse health effects, great caution should be taken to follow strict hygiene, good agricultural practices (GAPs) and good manufacturing practices (GMPs) during cultivation, harvest, storage, transport, and marketing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Microbiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food crops
KW - Parasitic plants
KW - Agriculture
KW - Pathogenic bacteria
KW - Horticultural products
KW - Fusarium oxysporum
KW - Bacteria
KW - Fresh Vegetables
KW - Fungi
KW - Health Hazards
KW - Spoilage
N1 - Accession Number: 16358280; Tournas, V. H. 1; Email Address: vtournas@cfsan.fda.gov; Affiliations: 1: Division of Natural Products, Food and Drug Administration, College Park, Maryland, USA.; Issue Info: Jan-Mar2005, Vol. 31 Issue 1, p33; Thesaurus Term: Food crops; Thesaurus Term: Parasitic plants; Thesaurus Term: Agriculture; Thesaurus Term: Pathogenic bacteria; Subject Term: Horticultural products; Subject Term: Fusarium oxysporum; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Fresh Vegetables; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Health Hazards; Author-Supplied Keyword: Spoilage; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/10408410590886024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16358280&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Hastings, Kenneth L.
AU - Bala, Shukal
AU - Vohr, Hans-Werner
T1 - Animal Models of Immunodeficiency.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 22
EP - 23
SN - 9783540441724
AB - This article offers information about animal models of immunodeficiency. The characteristics of immunodeficient animals are described. The advantages and disadvantages of using immunodeficient animal models are discussed. Several techniques used for making animals immunodeficient include chemical, radiological, biological, surgical or by genetic manipulation.
KW - ANIMAL models in research
KW - ANIMAL experimentation
KW - IMMUNODEFICIENCY
KW - IMMUNE response -- Regulation
KW - IMMUNOLOGY
N1 - Accession Number: 21873933; Hastings, Kenneth L. 1 Bala, Shukal 1 Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: Division of Special Pathogen and Immunologic Drug Products, Center For Drug Evaluation And Research, US Food and Drug Administration 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal 42096; Source Info: 2005, p22; Subject Term: ANIMAL models in research; Subject Term: ANIMAL experimentation; Subject Term: IMMUNODEFICIENCY; Subject Term: IMMUNE response -- Regulation; Subject Term: IMMUNOLOGY; Number of Pages: 2p; Document Type: Reference Entry
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Simeonova, Petia P.
AU - Vohr, Hans-Werner
T1 - Anti-Inflammatory (Nonsteroidal) Drugs.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 24
EP - 27
SN - 9783540441724
AB - This article offers information about several anti-inflammatory or nonsteroidal drugs (NSAID). These drugs belong to a group of dissimilar agents which are used to treat various conditions. It has analgesic, anti-inflammatory and antipyretic properties. The characteristics of NSAID drugs are described. A diagram is presented that illustrates the synthesis of prostagandins and leukotrienes.
KW - ANTI-inflammatory agents
KW - ANTIPYRETICS
KW - NONSTEROIDAL anti-inflammatory agents
KW - ANALGESICS
KW - LEUKOTRIENES
N1 - Accession Number: 21873939; Simeonova, Petia P. 1 Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal 42096; Source Info: 2005, p24; Subject Term: ANTI-inflammatory agents; Subject Term: ANTIPYRETICS; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: ANALGESICS; Subject Term: LEUKOTRIENES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Reference Entry
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21873939&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Yucesoy, Berran
AU - Johnson, Victor J.
AU - Luster, Michael I.
AU - Vohr, Hans-Werner
T1 - Cytokine Polymorphisms and Immunotoxicology.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 174
EP - 176
SN - 9783540441724
AB - The article presents an encyclopedia entry for cytokine polymorphisms and its immunotoxicology. it mentions the several types of polymorphisms in the genome. It describes the characteristics of single nucleotide polymorphisms. It explains the use of single nucleotide polymorphisms as a method for examining the genetic etiology of human diseases and in gene-environment interactions. It discusses its relevance to clinical trials of drugs.
KW - CYTOKINES
KW - GENETIC polymorphisms
KW - IMMUNOTOXICOLOGY
KW - GENOMES
KW - GENOTYPE-environment interaction
KW - ENCYCLOPEDIAS & dictionaries
N1 - Accession Number: 21874116; Yucesoy, Berran 1 Johnson, Victor J. 1 Luster, Michael I. 1; Email Address: mluster@cdc.gov Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal, 42096; Source Info: 2005, p174; Subject Term: CYTOKINES; Subject Term: GENETIC polymorphisms; Subject Term: IMMUNOTOXICOLOGY; Subject Term: GENOMES; Subject Term: GENOTYPE-environment interaction; Subject Term: ENCYCLOPEDIAS & dictionaries; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Chart; Document Type: Reference Entry
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Meade, B. Jean
AU - Fairley, Kimberly J.
AU - Vohr, Hans-Werner
T1 - Exposure Route and Respiratory Hypersensitivity.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 233
EP - 237
SN - 9783540441724
AB - The article presents an encyclopedia entry for exposure route and respiratory hypersensitivity. Respiratory hypersensitivity is the result of the induction of humoral- or cellular-mediated sensitization in the lung. It can be local or systemic immunologic response. It is classified as types I-IV. A recent data has demonstrated that dermal exposure may play a significant role in the development of respiratory track sensitization.
KW - RESPIRATORY allergy
KW - HYPERSENSITIVITY pneumonitis
KW - ALLERGY
KW - LUNGS -- Dust diseases
KW - RESPIRATORY diseases
N1 - Accession Number: 21874216; Meade, B. Jean 1 Fairley, Kimberly J. 1 Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal 42096; Source Info: 2005, p233; Subject Term: RESPIRATORY allergy; Subject Term: HYPERSENSITIVITY pneumonitis; Subject Term: ALLERGY; Subject Term: LUNGS -- Dust diseases; Subject Term: RESPIRATORY diseases; Number of Pages: 5p; Document Type: Reference Entry
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21874216&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Luster, Michael I.
AU - Vohr, Hans-Werner
T1 - Inflammatory Reactions, Acute Versus Chronic.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 345
EP - 347
SN - 9783540441724
AB - The article presents a comparison between acute and chronic inflammatory reactions. Acute inflammation is of short duration and relatively stereospecific. It is found to be associated with edema and neutrophil infiltration. On the other hand, chronic inflammation is less uniform and of longer duration.
KW - DEFINITIONS
KW - INFLAMMATION
KW - NEUTROPHILS
KW - GRANULOCYTES
KW - ANTI-inflammatory agents
KW - EDEMA
N1 - Accession Number: 21874396; Luster, Michael I. 1 Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Rd Morgantown, WV 26505 USA 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, D-42096 Wuppertal; Source Info: 2005, p345; Subject Term: DEFINITIONS; Subject Term: INFLAMMATION; Subject Term: NEUTROPHILS; Subject Term: GRANULOCYTES; Subject Term: ANTI-inflammatory agents; Subject Term: EDEMA; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Reference Entry
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Johnson, Victor J.
AU - Vohr, Hans-Werner
T1 - Tumor Necrosis Factor-α.
JO - Encyclopedic Reference of Immunotoxicology
JF - Encyclopedic Reference of Immunotoxicology
Y1 - 2005/01//
M3 - Reference Entry
SP - 674
EP - 677
SN - 9783540441724
AB - The article provides information on tumor necrosis factor (TNF)-α. TNF-α is a pleiotropic inflammatory cytokine that mediates roles in homeostasis, cell growth and tissue damage. The stimuli that trigger the production of TNF-α include bacterial products, oxidative stress and other cytokines. Moreover, the relevance of TNF-α with immunotoxicity and humans is discussed.
KW - TUMOR necrosis factor
KW - CYTOKINES
KW - HOMEOSTASIS
KW - OXIDATIVE stress
KW - IMMUNOTOXICOLOGY
N1 - Accession Number: 21874898; Johnson, Victor J. 1 Vohr, Hans-Werner 2; Email Address: hans-werner.vohr@bayerhealthcare.com; Affiliation: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: PH-PD, Toxicology, Bayer HealthCare AG, Aprather Weg 18a, Wuppertal, 42096; Source Info: 2005, p674; Subject Term: TUMOR necrosis factor; Subject Term: CYTOKINES; Subject Term: HOMEOSTASIS; Subject Term: OXIDATIVE stress; Subject Term: IMMUNOTOXICOLOGY; Number of Pages: 4p; Document Type: Reference Entry
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21874898&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Byun, Jung-A
AU - Heo, Yong
AU - Kim, Young-Ok
AU - Pyo, Myoung-Yun
T1 - Bisphenol A-induced downregulation of murine macrophage activities in vitro and ex vivo
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2005/01//
VL - 19
IS - 1
M3 - Article
SP - 19
EP - 24
SN - 13826689
AB - Abstract: Bisphenol A (BPA) is known to have detrimental effects on the reproductive system, but the toxicity of BPA on immune responses has not been systematically investigated. We investigated the effects of BPA exposure on the activities of murine peritoneal macrophages through evaluation of BPA-induced alteration of nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) synthesis, and expression of co-stimulatory molecules B7. Macrophages were examined ex vivo from mice orally treated with various doses of BPA for 5 consecutive days per week for 4 weeks followed by culture for 2 or 4 days in the presence of lipopolysaccharides (LPS). Macrophages from naive mice were also stimulated with LPS ± BPA for 2 or 4 days. NO production was decreased with the in vitro exposure to 1, 10 and 100μM BPA. NO production was lower in the BPA-exposed mice than the control mice with all doses. In vitro, BPA suppressed TNF-α secretion with significant reduction at 10 and 100μM BPA. Similar findings were observed with the macrophages from the BPA-exposed mice. This study provides the substantial evidence on BPA-induced alteration in macrophage activity. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RODENTS
KW - TUMOR necrosis factor
KW - CYTOKINES
KW - IMMUNE response
KW - B7.
KW - Bisphenol A
KW - Macrophages
KW - Nitric oxide
KW - Tumor necrosis factor-α
N1 - Accession Number: 15585768; Byun, Jung-A 1 Heo, Yong 2 Kim, Young-Ok 3 Pyo, Myoung-Yun 1; Email Address: mypyo@sdic.sookmyung.ac.kr; Affiliation: 1: College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong 2 Ka, Yongsan-ku, Seoul 140-742, Korea 2: Department of Occupational Health, College of Natural Sciences, Catholic University of Daegu, 330 Kumrak 1-ri, Hayang-eup, Kyongsan-si, Kyongbuk 712-702, Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-704, Korea; Source Info: Jan2005, Vol. 19 Issue 1, p19; Subject Term: RODENTS; Subject Term: TUMOR necrosis factor; Subject Term: CYTOKINES; Subject Term: IMMUNE response; Author-Supplied Keyword: B7.; Author-Supplied Keyword: Bisphenol A; Author-Supplied Keyword: Macrophages; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: Tumor necrosis factor-α; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.etap.2004.02.006
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Murphy, M. Dianne
AU - Goldkind, Sara F.
AD - US Food and Drug Administration
AD - US Food and Drug Administration
A2 - Santoro, Michael A.
A2 - Gorrie, Thomas M.
T1 - The Regulatory and Ethical Challenges of Pediatric Research
T2 - Ethics and the Pharmaceutical Industry
PB - Cambridge and New York:
PB - Cambridge University Press
Y1 - 2005///
SP - 48
EP - 67
N1 - Accession Number: 0876650; Reviewed Book ISBN: 0-521-85496-2; Keywords: Ethical; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200612
KW - Analysis of Health Care Markets I11
KW - Chemicals; Rubber; Drugs; Biotechnology L65
KW - Corporate Culture; Diversity; Social Responsibility M14
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0876650&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Abrams, Thomas
AD - US Food and Drug Administration
A2 - Santoro, Michael A.
A2 - Gorrie, Thomas M.
T1 - The Regulation of Prescription Drug Promotion
T2 - Ethics and the Pharmaceutical Industry
PB - Cambridge and New York:
PB - Cambridge University Press
Y1 - 2005///
SP - 153
EP - 168
N1 - Accession Number: 0876657; Reviewed Book ISBN: 0-521-85496-2; Keywords: Drug; Drugs; Prescription; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200612
KW - Analysis of Health Care Markets I11
KW - Chemicals; Rubber; Drugs; Biotechnology L65
KW - Marketing M31
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DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Delaney, Martin
AD - AIDS Foundation and US Department of Health and Human Services
A2 - Santoro, Michael A.
A2 - Gorrie, Thomas M.
T1 - AIDS Activism and the Pharmaceutical Industry
T2 - Ethics and the Pharmaceutical Industry
PB - Cambridge and New York:
PB - Cambridge University Press
Y1 - 2005///
SP - 300
EP - 325
N1 - Accession Number: 0876666; Reviewed Book ISBN: 0-521-85496-2; Keywords: AIDS; Pharmaceutical; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200612
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Chemicals; Rubber; Drugs; Biotechnology L65
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0876666&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Sun, Haihao
AU - Sloan, Andrew
AU - Mangner, Thomas
AU - Vaishampayan, Ulka
AU - Muzik, Otto
AU - Collins, Jerry
AU - Douglas, Kirk
AU - Shields, Anthony
T1 - Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer.
JO - European Journal of Nuclear Medicine & Molecular Imaging
JF - European Journal of Nuclear Medicine & Molecular Imaging
Y1 - 2005/01//
VL - 32
IS - 1
M3 - Article
SP - 15
EP - 22
PB - Springer Science & Business Media B.V.
SN - 16197070
AB - Purpose: FMAU (1-(2'-deoxy-2'-fluoro-Β-Darabinofuranosyl)thymine) is a thymidine analog that can be phosphorylated by thymidine kinase and incorporated into DNA. This first-in-human study of [18F]FMAU was conducted as a pilot in patients to determine its biodistribution and suitability for imaging DNA synthesis in tumors using positron emission tomography (PET). Methods: Fourteen patients with diverse cancers (brain, prostate, colorectal, lung, and breast) were imaged with [18F]FMAU. We obtained dynamic PET images for 60 min and a whole-body image. Blood and urine samples were analyzed by high-performance liquid chromatography to measure metabolites and clearance. Results: Active tumors in the breast, brain, lung and prostate were clearly visualized with standardized uptake values (SUVs) of 2.19, 1.28, 2.21, and 2.27-4.42, respectively. Unlike with other tracers of proliferation, low uptake of [18F]FMAU was seen in the normal bone marrow (SUVmean 0.7), allowing visualization of metastatic prostate cancer (SUV 3.07). Low background was also observed in the brain, pelvis, and thorax, aside from heart uptake (SUV 3.36-8.78). In the abdomen, increased physiological uptake was seen in the liver (SUV 10.07-20.88) and kidneys (SUV 7.18-15.66) due to metabolism and/or excretion, but the urinary bladder was barely visible (SUVmean 2.03). On average, 95% of the activity in the blood was cleared within 10 min post injection and an average of 70% of the activity in the urine was intact FMAU at 60 min post injection. Conclusion: Tumors in the brain, prostate, thorax, and bone can be clearly visualized with FMAU. In the upper abdomen, visualization is limited by the physiological uptake by the liver and kidneys. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Nuclear Medicine & Molecular Imaging is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMISSION tomography
KW - DNA synthesis
KW - THYMIDINE
KW - ONCOLOGY
KW - NUCLEAR medicine
KW - RADIOACTIVE tracers in cytology
KW - FMAU
KW - PET
KW - Proliferation
N1 - Accession Number: 15397730; Sun, Haihao 1 Sloan, Andrew 1 Mangner, Thomas 1 Vaishampayan, Ulka 1 Muzik, Otto 1 Collins, Jerry 2 Douglas, Kirk 1 Shields, Anthony 1; Email Address: shieldsA@karmanos.org; Affiliation: 1: Karmanos Cancer Institute, Departments of Medicine, Radiology and Pediatrics, Wayne State University 2: Food and Drug Administration; Source Info: 2005, Vol. 32 Issue 1, p15; Subject Term: EMISSION tomography; Subject Term: DNA synthesis; Subject Term: THYMIDINE; Subject Term: ONCOLOGY; Subject Term: NUCLEAR medicine; Subject Term: RADIOACTIVE tracers in cytology; Author-Supplied Keyword: FMAU; Author-Supplied Keyword: PET; Author-Supplied Keyword: Proliferation; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 8p; Document Type: Article
L3 - 10.1007/s00259-004-1713-8
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-16871-001
AN - 2008-16871-001
AU - Snyder, Lori Anderson
AU - Chen, Peter Y.
AU - Grubb, Paula L.
AU - Roberts, Rashaun K.
AU - Sauter, Steven L.
AU - Swanson, Naomi G.
ED - Perrewé, Pamela L.
ED - Ganster, Daniel C.
ED - Perrewé, Pamela L., (Ed)
ED - Ganster, Daniel C., (Ed)
T1 - Workplace aggression and violence against individuals and organizations: Causes, consequences, and interventions.
T2 - Exploring interpersonal dynamics.
T3 - Research in occupational stress and well being; Vol 4; ISSN: 1479-3555 (Print)
Y1 - 2005///
VL - 4
SP - 1
EP - 65
CY - US
PB - Elsevier Science/JAI Press
SN - 1479-3555
SN - 0-7623-1153-3
SN - 978-0-7623-1153-8
N1 - Accession Number: 2008-16871-001. Partial author list: First Author & Affiliation: Snyder, Lori Anderson; University of Oklahoma, OK, US. Release Date: 20090914. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-1153-3, Hardcover; 978-0-7623-1153-8, Hardcover. Language: English. Major Descriptor: Aggressive Behavior; Intervention; Organizations; Working Conditions; Workplace Violence. Minor Descriptor: Physical Abuse; Verbal Abuse; Consequence. Classification: Industrial & Organizational Psychology (3600); Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 65.
AB - This chapter examines aggression at work perpetrated by individual insiders by bringing together streams of research that have often been examined separately. A comparison of the similarities and differences of aggression toward individuals, such as verbal abuse or physical attack, and aggression toward organizations, such as embezzlement or work slowdowns, is shown to provide important insights about the causes and consequences of workplace aggression. We propose a comprehensive model based on the integration of prior theoretical treatments and empirical findings. The model attempts to offer a framework to systematically examine psychological and organizational mechanisms underlying workplace aggression, and to explain the reasons why workplace violence policies and procedures sometimes fail. A set of research propositions is also suggested to assist in achieving this end in future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace aggression
KW - workplace violence
KW - individuals
KW - organizations
KW - interventions
KW - verbal & physical abuse
KW - embezzlement
KW - work slowdowns
KW - 2005
KW - Aggressive Behavior
KW - Intervention
KW - Organizations
KW - Working Conditions
KW - Workplace Violence
KW - Physical Abuse
KW - Verbal Abuse
KW - Consequence
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16871-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-16871-003
AN - 2008-16871-003
AU - Tausig, Mark
AU - Fenwick, Rudy
AU - Sauter, Steven L.
AU - Murphy, Lawrence R.
AU - Graif, Corina
ED - Perrewé, Pamela L.
ED - Ganster, Daniel C.
ED - Perrewé, Pamela L., (Ed)
ED - Ganster, Daniel C., (Ed)
T1 - The changing nature of job stress: Risk and resources.
T2 - Exploring interpersonal dynamics.
T3 - Research in occupational stress and well being; Vol 4; ISSN: 1479-3555 (Print)
Y1 - 2005///
VL - 4
SP - 93
EP - 126
CY - US
PB - Elsevier Science/JAI Press
SN - 1479-3555
SN - 0-7623-1153-3
SN - 978-0-7623-1153-8
N1 - Accession Number: 2008-16871-003. Partial author list: First Author & Affiliation: Tausig, Mark; University of Akron, OH, US. Release Date: 20090914. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-1153-3, Hardcover; 978-0-7623-1153-8, Hardcover. Language: English. Major Descriptor: Occupational Stress; Personnel; Quality of Work Life; Working Conditions. Minor Descriptor: Risk Factors. Classification: Industrial & Organizational Psychology (3600). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. References Available: Y. Page Count: 34.
AB - The nature of work has changed in the past 30 years but we do not know what these changes have meant for worker job stress. In this chapter we compare data from three surveys of the quality of work life from 1972 to 2002. At the most general level, work today is less stressful than it was in 1972. Workers report fewer job demands, more decision latitude, less job strain, more job security and greater access to job resources and job support. However, these changes have not affected all workers equally. Women, those with less education, non self-employed workers, blue collar workers and workers in manufacturing industries showed the greatest decreases in job stress although levels of job stress remain higher than for comparison groups (men, college educated, white collar, service workers). Changes were not always linear across time suggesting that some aspects of job strain are sensitive to economic cycles. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job stress
KW - workers
KW - quality of work life
KW - work
KW - changes
KW - risk
KW - resources
KW - 2005
KW - Occupational Stress
KW - Personnel
KW - Quality of Work Life
KW - Working Conditions
KW - Risk Factors
KW - 2005
U1 - Sponsor: National Institute for Occupational Safety and Health, Organizational Science and Human Factors Branch. Recipients: No recipient indicated
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Beland, Frederick A.
AU - Benson, R. Wayne
AU - Mellick, Paul W.
AU - Kovatch, Robert M.
AU - Roberts, Dean W.
AU - Fang, Jia-Long
AU - Doerge, Daniel R.
T1 - Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/01//
VL - 43
IS - 1
M3 - Article
SP - 1
EP - 19
SN - 02786915
AB - Abstract: Urethane is a carcinogen to which there is widespread exposure through the consumption of fermented foods and alcoholic beverages. In this study, we have assessed the carcinogenicity of urethane in combination with ethanol. Male and female B6C3F1 mice (48 mice per sex per group) were exposed to 0, 10, 30, or 90ppm urethane in the presence of 0%, 2.5%, or 5% ethanol in drinking water ad libitum for two years, at which time the extent of tumorigenesis was assessed. Additional mice (four per sex per group) received the same doses for four weeks to assess serum levels of urethane and ethanol, DNA adduct formation, and the induction of microsomal cytochromes P450, cell proliferation, and apoptosis. Urethane decreased cell replication in the livers of female, but not male, mice, decreased cell replication in the lungs of both sexes, and induced cytochrome P450 2E1 in the livers of female mice. Hepatic levels of the DNA adduct 1,N6-ethenodeoxyadenosine were increased by exposure to urethane and decreased by treatment with ethanol. Animal weights and survival were not affected by ethanol; in contrast, urethane administration decreased body weights and survival. Urethane caused dose-dependent increases in liver, lung, and harderian gland adenoma or carcinoma and hemangiosarcoma of the liver and heart in both sexes, mammary gland and ovarian tumors in females, and squamous cell papilloma or carcinoma of the skin and forestomach in males. The increase in hepatocellular tumors occurred in a relatively linear manner and was attributed to the formation of 1,N6-ethenodeoxyadenosine in hepatic DNA coupled with an increase in cell replication. Hemangiosarcomas were observed only at the 90ppm urethane dose and were probably a result of high-dose urethane-induced toxicity. Lung alveolar/bronchiolar and harderian gland adenoma or carcinoma increased in a relatively linear manner, suggestive of a genotoxic mechanism for tumor induction. Ethanol induced a dose-dependent trend in hepatocellular adenoma or carcinoma in male mice, with the incidence being marginally increased at the highest dose. In female mice administered 10ppm and 90ppm urethane, ethanol caused dose-related increases in alveolar/bronchiolar adenoma or carcinoma and hemangiosarcoma of the heart, respectively. This may be due to ethanol decreasing the first-pass clearance of urethane, thus, increasing systemic distribution. In male mice a different relationship was observed: ethanol caused a dose-related decrease in alveolar/bronchiolar and harderian gland adenoma or carcinoma in mice administered 30ppm urethane. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URETHANE
KW - CARCINOGENS
KW - ALCOHOL
KW - LIVER -- Cancer
KW - MICE as laboratory animals
KW - ANOVA, analysis of variance
KW - LC-ES/MS/MS, liquid chromatography-electrospray mass spectrometry/mass spectrometry
KW - PCNA, proliferating cell nuclear antigen
N1 - Accession Number: 15559788; Beland, Frederick A. 1; Email Address: fbeland@nctr.fda.gov Benson, R. Wayne 1 Mellick, Paul W. 2 Kovatch, Robert M. 2 Roberts, Dean W. 1 Fang, Jia-Long 1 Doerge, Daniel R. 1; Affiliation: 1: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, Jefferson AR 72079, United States 2: Pathology Associates International, National Center for Toxicological Research, Jefferson AR 72079, United States; Source Info: Jan2005, Vol. 43 Issue 1, p1; Subject Term: URETHANE; Subject Term: CARCINOGENS; Subject Term: ALCOHOL; Subject Term: LIVER -- Cancer; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: ANOVA, analysis of variance; Author-Supplied Keyword: LC-ES/MS/MS, liquid chromatography-electrospray mass spectrometry/mass spectrometry; Author-Supplied Keyword: PCNA, proliferating cell nuclear antigen; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.fct.2004.07.018
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2005-04218-025
AN - 2005-04218-025
AU - Holden, E. Wayne
AU - Stephens, Robert L.
AU - Santiago, Rolando L.
ED - Steele, Ric G.
ED - Roberts, Michael C.
ED - Steele, Ric G., (Ed)
ED - Roberts, Michael C., (Ed)
T1 - Methodological Challenges in the National Evaluation of the Comprehensive Community Mental Health Services for Children and Their Families Program.
T2 - Handbook of mental health services for children, adolescents, and families.
T3 - Issues in clinical child psychology
Y1 - 2005///
SP - 387
EP - 401
CY - New York, NY, US
PB - Kluwer Academic/Plenum Publishers
SN - 0-306-48560-5
AD - Holden, E. Wayne, Applied Research Division, ORC Macro, Atlanta, GA, US, 30329
N1 - Accession Number: 2005-04218-025. Partial author list: First Author & Affiliation: Holden, E. Wayne; Applied Research Division, ORC Macro, Atlanta, GA, US. Release Date: 20060117. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-306-48560-5, Hardcover. Language: English. Conference Information: Annual Meeting of the American Psychological Association, 110th, Aug, 2002, Chicago, IL, US. Conference Note: Portions of this chapter were based upon a presentation made at the aforementioned conference. Major Descriptor: Adolescent Development; Childhood Development; Community Mental Health Services; Emotional Disturbances; Program Evaluation. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 15.
AB - The Comprehensive Community Mental Health Services for Children and Their Families Program is the federal government's principal response to the service needs of the estimated 4.5-6.3 million children in the US who have serious emotional disturbance (Friedman, Katz-Leavy, Manderscheid, & Sondheimer, 1999). The program provides grants to states, communities, territories, and American Indian tribes to improve and expand their systems of care to meet the needs of children and adolescents with serious emotional disturbance and their families. These include children and youth with a serious emotional disturbance (SED) from birth to the age of 21 years who currently have, or at any time during the past year, had a mental, behavioral, or emotional disorder of sufficient duration to meet diagnostic criteria specified in the DSM-IV (American Psychiatric Association, 1994). The two major goals of this large-scale program evaluation are (1) to obtain an overall program evaluation of the Comprehensive Community Mental Health Services for Children and Their Families Program that informs federal policy making and (2) to develop evaluation capacity locally within the funded communities. In the conduct of a large-scale program evaluation, a significant amount of tension can exist between these two goals. This dynamic tension creates a unique contextual challenge that has implications for the overall design and successful implementation of evaluation strategies. This chapter describes the methodological challenges involved in this large-scale evaluation. These challenges are important to consider as we move into the future as they parallel those encountered in efforts to evaluate the effects of other socially complex services delivered in community settings (Herrell & Straw, 2002; Wolff, 2000). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Comprehensive Community Mental Health Services for Children and Their Families Program
KW - children
KW - adolescents
KW - serious emotional disturbance
KW - program evaluation
KW - 2005
KW - Adolescent Development
KW - Childhood Development
KW - Community Mental Health Services
KW - Emotional Disturbances
KW - Program Evaluation
KW - 2005
DO - 10.1007/0-387-23864-6_25
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04218-025&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-04216-021
AN - 2005-04216-021
AU - Taub, Jennifer
AU - Pearrow, Melissa
ED - Goldstein, Sam
ED - Brooks, Robert B.
ED - Goldstein, Sam, (Ed)
ED - Brooks, Robert B., (Ed)
T1 - Resilience through Violence Prevention in Schools.
T2 - Handbook of resilience in children.
Y1 - 2005///
SP - 357
EP - 371
CY - New York, NY, US
PB - Kluwer Academic/Plenum Publishers
SN - 0-306-48571-0
AD - Taub, Jennifer, Center for Mental Health Services, Research University of Massachusetts Medical School, Worcester, MA, US, 01655
N1 - Accession Number: 2005-04216-021. Partial author list: First Author & Affiliation: Taub, Jennifer; Center for Mental Health Services, Research University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20050718. Correction Date: 20130218. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-306-48571-0, Hardcover. Language: English. Major Descriptor: Prevention; Resilience (Psychological); School Based Intervention; Violence. Minor Descriptor: Classrooms; Mental Health Programs; Strategies. Classification: Educational Psychology (3500). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 15.
AB - Programs such as school-based mental health clinics, drug and alcohol prevention programs, weapons-reduction programs, school-community partnerships, and school-based family support services (to name but a few) all target the social and emotional well being of our nation's students. Many of these could be said to broadly foster resilience. In our focus on 'school-wide' interventions, we are taking a primary prevention perspective. These types of interventions are intentionally designed to reduce the future incidence of adjustment problems in currently normal populations, and directed at the promotion of mental health functioning. This chapter will broadly focus on school- and classroom-based programs that are implemented within the school environment and are specifically designed to promote social and emotional competence and prevent the development of violent behaviors. Our focus is on universal (school-wide) and primary prevention programs that target the entire school population. Violence prevention programs that have been empirically validated will be reviewed, as well as strategies necessary to examine the effectiveness of such programs. Needs and future directions of violence prevention programming and research will also be highlighted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - resilience
KW - school-wide intervention
KW - violence
KW - classroom-based programs
KW - social & emotional competence
KW - schools
KW - mental health clinics
KW - primary prevention
KW - effectiveness examination strategies
KW - 2005
KW - Prevention
KW - Resilience (Psychological)
KW - School Based Intervention
KW - Violence
KW - Classrooms
KW - Mental Health Programs
KW - Strategies
KW - 2005
DO - 10.1007/0-306-48572-9_21
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04216-021&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2005-04647-010
AN - 2005-04647-010
AU - Walsh, W. Bruce
AU - Eggerth, Donald E.
ED - Walsh, W. Bruce
ED - Savickas, Mark L.
ED - Walsh, W. Bruce, (Ed)
ED - Savickas, Mark L., (Ed)
T1 - Vocational Psychology and Personality: The Relationship of the Five-Factor Model to Job Performance and Job Satisfaction.
T2 - Handbook of vocational psychology: Theory, research, and practice, 3rd ed.
T3 - Contemporary topics in vocational psychology
Y1 - 2005///
SP - 267
EP - 295
CY - Mahwah, NJ, US
PB - Lawrence Erlbaum Associates Publishers
SN - 0-8058-4517-8
N1 - Accession Number: 2005-04647-010. Partial author list: First Author & Affiliation: Walsh, W. Bruce; Ohio State University, Columbus, OH, US. Release Date: 20060828. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-8058-4517-8, Hardcover. Language: English. Major Descriptor: Five Factor Personality Model; Job Performance; Job Satisfaction; Personality; Well Being. Minor Descriptor: Applied Psychology; Occupations. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 29.
AB - Recently, there has been renewed interest in the role that personality plays in job-related performance, satisfaction, and well-being. Much of this renewed interest is attributable to two advances: one methodological and the other theoretical (Hurtz & Donovan, 2000). The technique of meta-analysis provides researchers with an objective method to equate and summarize results across multiple studies. Over the last several decades, meta-analysis has evolved from a simple summing of effect sizes across studies into a complex statistical procedure requiring many well-informed decisions regarding corrections for error and bias in data sets. A second reason for the renewed interest in personality measures was the emergence of the Five Factor Model (FFM) of personality (Hogan & Roberts, 2001). The FFM provided a much-needed, empirically validated schema for classifying personality measures and imposing order on the confusing mass of personality and job performance and job satisfaction literature. The resulting order laid the foundation for new investigations of the relationship between personality and job performance and job satisfaction. An additional important reason for the renewed interest in the relationship between personality and job performance is that for selection purposes, personality assessment can add a relatively race- and gender-neutral increment to the predictive validity of cognitive assessment. It is in this context that we have explored the topic of vocational psychology and personality by first describing the FFM, then reviewing the meta-analytic studies focusing on personality and job performance; third, discussing meta-analytic studies focusing on personality and job satisfaction; and fourth, concluding with a review of relevant research focusing on personality and well-being. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vocational psychology
KW - personality
KW - job satisfaction
KW - job performance
KW - Five-Factor Model of personality
KW - well-being
KW - 2005
KW - Five Factor Personality Model
KW - Job Performance
KW - Job Satisfaction
KW - Personality
KW - Well Being
KW - Applied Psychology
KW - Occupations
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04647-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - ABST
AU - Atkins, David
AU - Siegel, Joanna
AU - Slutsky, Jean
T1 - Making Policy When The Evidence Is In Dispute.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/01//Jan/Feb2005
VL - 24
IS - 1
M3 - Abstract
SP - 102
EP - 113
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Policymakers often struggle with medical issues that are the subject of fierce scientific debate. On closer examination, many of these debates are manifestations of conflicting perspectives and values as much as disagreements over the evidence. We summarize common factors underlying recent debates and outline a series of questions that can help disentangle questions of evidence from those of values. These questions focus on identifying the most important outcomes, evaluating the quality of evidence, and assessing the trade-offs involved. We then use four recent policy debates -- involving prostate-specific antigen (PSA) screening, high-dose chemotherapy for breast cancer, antibiotic therapy for otitis media, and newborn hearing screening -- to illustrate how this approach can help clarify areas of agreement and disagreement of the opposing sides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - DECISION making
KW - THERAPEUTICS
KW - EVIDENCE
KW - MEDICAL care
KW - QUALITY
N1 - Accession Number: 15610455; Atkins, David 1; Email Address: datkins@ahrq.gov Siegel, Joanna 2 Slutsky, Jean 3; Affiliation: 1: Chief Medical Officer, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. 2: Director, Research Initiative in Clinical Economics, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. 3: Director, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland.; Source Info: Jan/Feb2005, Vol. 24 Issue 1, p102; Subject Term: MEDICAL research; Subject Term: DECISION making; Subject Term: THERAPEUTICS; Subject Term: EVIDENCE; Subject Term: MEDICAL care; Subject Term: QUALITY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Abstract
L3 - 10.1377/hlthaff.24.1.102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15610455&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Clancy, Carolyn M.
AU - Cronin, Kelly
T1 - Evidence-Based Decision Making: Global Evidence, Local Decisions.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/01//Jan/Feb2005
VL - 24
IS - 1
M3 - Abstract
SP - 151
EP - 162
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Variations in health care services have been well documented worldwide. The result is that increased health care spending is not uniformly associated with improved health. Interest in increasing the value obtained from health care investments has stimulated efforts to develop the best science and apply it to health care delivery. Advances in communications and information technology have made such developments of the scientific basis for health care a truly global enterprise, but its application must remain local. Consumers' use of evidence-based information to choose providers, make treatment decisions, and play a more active role represents the ultimate local application of scientific information. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - DECISION making
KW - EVIDENCE-based medicine
KW - MEDICAL care
KW - MEDICAL care costs
KW - THERAPEUTICS
N1 - Accession Number: 15610462; Clancy, Carolyn M. 1; Email Address: cclancy@ahrq.gov Cronin, Kelly 2; Affiliation: 1: Director, Agency for Healthcare Research and quality (AHRQ), Rockville, Maryland. 2: Senior Adviser, Office of the National Coordinator for Health Information Technology, Department of Health and Human Services, Washington, D.C.; Source Info: Jan/Feb2005, Vol. 24 Issue 1, p151; Subject Term: MEDICAL research; Subject Term: DECISION making; Subject Term: EVIDENCE-based medicine; Subject Term: MEDICAL care; Subject Term: MEDICAL care costs; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Abstract
L3 - 10.1377/hlthaff.24.1.151
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15610462&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Zuvekas, Samuel H.
T1 - Prescription Drugs And The Changing Patterns Of Treatment For Mental Disorders, 1996-2001.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/01//Jan/Feb2005
VL - 24
IS - 1
M3 - Abstract
SP - 195
EP - 205
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - This paper uses detailed data on prescription drug and other services from the Medical Expenditure Panel Survey (MEPS) to examine recent trends in mental health and substance abuse (MH/SA) treatment between 1996 and 2001. While use of ambulatory services remained constant, prescription drug use increased rapidly, with the result that 5.5 million more Americans received treatment in 2001. Prescription drug spending increased at a real rate of almost 20 percent a year. About one-third of this increase came from more MH/SA medication users and two-thirds from higher costs per user. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - MEDICINE -- Formulae, receipts, prescriptions
KW - MENTAL illness
KW - THERAPEUTICS
KW - HEALTH surveys
KW - UNITED States
N1 - Accession Number: 15610472; Zuvekas, Samuel H. 1; Email Address: szuvekas@ahrq.gov; Affiliation: 1: Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland.; Source Info: Jan/Feb2005, Vol. 24 Issue 1, p195; Subject Term: DRUGS; Subject Term: MEDICINE -- Formulae, receipts, prescriptions; Subject Term: MENTAL illness; Subject Term: THERAPEUTICS; Subject Term: HEALTH surveys; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Document Type: Abstract
L3 - 10.1377/hlthaff.24.1.195
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15610472&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106583342
T1 - Making policy when the evidence is in dispute...Atkins D
AU - Siegel J
AU - Slutsky J
Y1 - 2005/01//Jan/Feb2005
N1 - Accession Number: 106583342. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Decision Making, Clinical
KW - Medical Practice, Evidence-Based
KW - Policy Making
KW - Antibiotics -- Therapeutic Use
KW - Bone Marrow Transplantation
KW - Breast Neoplasms -- Therapy
KW - Cancer Screening
KW - Chemotherapy, Cancer
KW - Clinical Research -- Standards
KW - Health Policy
KW - Hearing Screening -- In Infancy and Childhood
KW - Infant, Newborn
KW - Insurance, Health
KW - Otitis Media -- Drug Therapy
KW - Prostate-Specific Antigen
KW - Prostatic Neoplasms -- Prevention and Control
KW - Treatment Outcomes
SP - 102
EP - 113
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 24
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Policymakers often struggle with medical issues that are the subject of fierce scientific debate. On closer examination, many of these debates are manifestations of conflicting perspectives and values as much as disagreements over the evidence. We summarize common factors underlying recent debates and outline a series of questions that can help disentangle questions of evidence from those of values. These questions focus on identifying the most important outcomes, evaluating the quality of evidence, and assessing the trade-offs involved. We then use four recent policy debates-involving prostate-specific antigen (PSA) screening, high-dose chemotherapy for breast cancer, antibiotic therapy for otitis media, and newborn hearing screening-to illustrate how this approach can help clarify areas of agreement and disagreement of the opposing sides.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality (AHRQ), Rockville, MD
U2 - PMID: 15647220.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106583342&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106583356
T1 - Evidence-based decision making: global evidence, local decisions.
AU - Clancy CM
AU - Cronin K
Y1 - 2005/01//Jan/Feb2005
N1 - Accession Number: 106583356. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Decision Making, Clinical
KW - Health Care Delivery -- Standards
KW - Medical Practice, Evidence-Based
KW - Access to Information
KW - Clinical Research
KW - Electronic Health Records
KW - Drug Approval
KW - Information Technology
KW - Insurance, Health
KW - Medicare
KW - Policy Making
KW - Practice Guidelines
KW - Quality Improvement
KW - Systematic Review
SP - 151
EP - 162
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 24
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Variations in health care services have been well documented worldwide. The result is that increased health care spending is not uniformly associated with improved health. Interest in increasing the value obtained from health care investments has stimulated efforts to develop the best science and apply it to health care delivery. Advances in communications and information technology have made such developments of the scientific basis for health care a truly global enterprise, but its application must remain local. Consumers' use of evidence-based information to choose providers, make treatment decisions, and play a more active role represents the ultimate local application of scientific information.
SN - 0278-2715
AD - Director, Agency for Healthcare Research and Quality (AHRQ), Rockville, MD; cclancy@ahrq.gov
U2 - PMID: 15647226.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106583356&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106583365
T1 - Trends. Prescription drugs and the changing patterns of treatment for mental disorders, 1996-2001.
AU - Zuvekas SH
Y1 - 2005/01//Jan/Feb2005
N1 - Accession Number: 106583365. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Drug Therapy -- Trends
KW - Drugs, Prescription -- Economics
KW - Mental Disorders -- Drug Therapy
KW - Substance Abuse -- Drug Therapy
KW - Adult
KW - Aged
KW - Antidepressive Agents -- Economics
KW - Costs and Cost Analysis
KW - Female
KW - Health Care Costs
KW - Health Policy
KW - Health Services Accessibility
KW - Insurance, Health -- Economics
KW - Insurance, Pharmaceutical Services
KW - Male
KW - Managed Care Programs -- Economics
KW - Mental Health Services -- Utilization
KW - Middle Age
KW - Psychotropic Drugs -- Economics
KW - Sex Factors
KW - United States
KW - Human
SP - 195
EP - 205
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 24
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - This paper uses detailed data on prescription drug and other services from the Medical Expenditure Panel Survey (MEPS) to examine recent trends in mental health and substance abuse (MH/SA) treatment between 1996 and 2001. While use of ambulatory services remained constant, prescription drug use increased rapidly, with the result that 5.5 million more Americans received treatment in 2001. Prescription drug spending increased at a real rate of almost 20 percent a year. About one-third of this increase came from more MH/SA medication users and two-thirds from higher costs per user.
SN - 0278-2715
AD - Senior Economist, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD; szuvekas@ahrq.gov
U2 - PMID: 15647230.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106583365&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gebo, Kelly A.
AU - Fleishman, John A.
AU - Conviser, Richard
AU - Reilly, Erin D.
AU - Korthuis, Todd
AU - Moore, Richard D.
AU - Hellinger, James
AU - Keiser, Philip
AU - Rubin, Haya R.
AU - Crane, Lawrence
AU - Hellinger, Fred J.
AU - Christopher Mathews, W.
T1 - Racial and Gender Disparities in Receipt of Highly Active Antiretroviral Persist in a Multistate Sample of HIV Patients in 2001.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/01//1/1/2005
VL - 38
IS - 1
M3 - Article
SP - 96
EP - 103
SN - 15254135
AB - Examines demographic and clinical differences associated with receipt of highly active antiretroviral therapy (HAART) and the association of outpatient utilization with HAART. Redaction of persistent disparities in women; Evidence for racial and ethnic disparities in the receipt of antiretroviral therapy; Risk factors for HIV transmission.
KW - ANTIRETROVIRAL agents
KW - DRUG utilization
KW - HIV infections
KW - HIV-positive women
KW - AIDS (Disease) -- Transmission
KW - African American
KW - disparities
KW - female
KW - gender
KW - highly active antiretroviral therapy
KW - injection drug use
KW - race
N1 - Accession Number: 15838748; Gebo, Kelly A. 1; Email Address: kgebo@jhmi.edu Fleishman, John A. 2 Conviser, Richard 3 Reilly, Erin D. 1 Korthuis, Todd 4 Moore, Richard D. 1 Hellinger, James 5 Keiser, Philip 6 Rubin, Haya R. 1 Crane, Lawrence 7 Hellinger, Fred J. 1 Christopher Mathews, W. 8; Affiliation: 1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 2: Agency for Healthcare Research and Quality, Rockville, MD 3: Health Resources and Services Administration, Rockville, MD 4: Department of Medicine, Oregon Health and Science University, Portland, OR 5: Community Medical Alliance, Boston, MA 6: Parkland Health and Hospital Systems, Dallas, TX 7: Wayne State University, Detroit, MI 8: Department of Medicine, University of California, La Jolla, CA; Source Info: 1/1/2005, Vol. 38 Issue 1, p96; Subject Term: ANTIRETROVIRAL agents; Subject Term: DRUG utilization; Subject Term: HIV infections; Subject Term: HIV-positive women; Subject Term: AIDS (Disease) -- Transmission; Author-Supplied Keyword: African American; Author-Supplied Keyword: disparities; Author-Supplied Keyword: female; Author-Supplied Keyword: gender; Author-Supplied Keyword: highly active antiretroviral therapy; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: race; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=15838748&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gebo, Kelly A.
AU - Fleishman, John A.
AU - Conviser, Richard
AU - Reilly, Erin D.
AU - Korthuis, Todd
AU - Moore, Richard D.
AU - Hellinger, James
AU - Keiser, Philip
AU - Rubin, Haya R.
AU - Crane, Lawrence
AU - Hellinger, Fred J.
AU - Christopher Mathews, W.
T1 - Racial and Gender Disparities in Receipt of Highly Active Antiretroviral Persist in a Multistate Sample of HIV Patients in 2001.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/01//1/1/2005
VL - 38
IS - 1
M3 - Article
SP - 96
EP - 103
SN - 15254135
AB - Examines demographic and clinical differences associated with receipt of highly active antiretroviral therapy (HAART) and the association of outpatient utilization with HAART. Redaction of persistent disparities in women; Evidence for racial and ethnic disparities in the receipt of antiretroviral therapy; Risk factors for HIV transmission.
KW - ANTIRETROVIRAL agents
KW - DRUG utilization
KW - HIV infections
KW - HIV-positive women
KW - AIDS (Disease) -- Transmission
KW - African American
KW - disparities
KW - female
KW - gender
KW - highly active antiretroviral therapy
KW - injection drug use
KW - race
N1 - Accession Number: 15838748; Gebo, Kelly A. 1; Email Address: kgebo@jhmi.edu; Fleishman, John A. 2; Conviser, Richard 3; Reilly, Erin D. 1; Korthuis, Todd 4; Moore, Richard D. 1; Hellinger, James 5; Keiser, Philip 6; Rubin, Haya R. 1; Crane, Lawrence 7; Hellinger, Fred J. 1; Christopher Mathews, W. 8; Source Information: 1/1/2005, Vol. 38 Issue 1, p96; Subject: ANTIRETROVIRAL agents; Subject: DRUG utilization; Subject: HIV infections; Subject: HIV-positive women; Subject: AIDS (Disease) -- Transmission; Author-Supplied Keyword: African American; Author-Supplied Keyword: disparities; Author-Supplied Keyword: female; Author-Supplied Keyword: gender; Author-Supplied Keyword: highly active antiretroviral therapy; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: race; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=15838748&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Joshua R. Hayes
AU - David D. Wagner
AU - Linda L. English
AU - Lewis E. Carr
AU - Sam W. Joseph
T1 - Distribution of streptogramin resistance determinants among Enterococcus faecium from a poultry production environment of the USA.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2005/01//
VL - 55
IS - 1
M3 - Article
SP - 123
EP - 126
SN - 03057453
N1 - Accession Number: 18250028; Joshua R. Hayes 1; David D. Wagner 2; Linda L. English 2; Lewis E. Carr 3; Sam W. Joseph 1; Affiliations: 1: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742;; 2: ment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742; , 1 , Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708;; 3: ment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742; , 1 , Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708; , 2 , Department of Biological Resources Engineering, University of Maryland, College Park, MD 20742, USA; Issue Info: Jan2005, Vol. 55 Issue 1, p123; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18250028&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cieri, Ugo R.
T1 - Identification and Estimation of the Levo Isomer in Raw Materials and Finished Products Containing Atropine and/or Hyoscyamine.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 1
EP - 4
SN - 10603271
AB - Presents a study which sought to develop a method for identifying and estimating the isomers of atropine in raw materials and commercial preparations. Presence of identical molecular formulas in atropine and hyoscyamine; Percentage of hyoscyamine sulfate contained in hyoscyamine sulfate; Use of liquid chromatography in the study; Identification of atropine and hyoscyamine as the principal active constituents of Atropa belladonna.
KW - ATROPINE
KW - PARASYMPATHOLYTIC agents
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - BELLADONNA (Plant)
N1 - Accession Number: 16123832; Cieri, Ugo R. 1; Email Address: ucieri@ora.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 2nd and Chestnut Sts, Philadelphia, PA 19106; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p1; Subject Term: ATROPINE; Subject Term: PARASYMPATHOLYTIC agents; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: BELLADONNA (Plant); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16123832&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DeVries, Jonathan W.
AU - Rader, Jeanne I.
AU - Keagy, Pamela M.
AU - Hudson, Carol A.
T1 - Microbiological Assay-Trienzyme Procedure for Total Folates in Cereals and Cereal Foods: Collaborative Study.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 5
EP - 15
SN - 10603271
AB - Cites a study on development of a microbiological assay with the use of trienzyme procedure for the analysis of folates in cereals and cereal foods. Reference to the mandate by the U.S. Food and Drug Administration on the fortication of enriched cereal-grain products with folic acid; Identification of folate and its polyglutamyl homologs as essential vitamins for humans; Selection of cereal-based products with a range of protein, fat, and carbohydrate in the study; Potential of folate supplementation to reduce the the incidence of neural tube defects in certain high-risk populations.
KW - MICROBIOLOGICAL assay
KW - BIOLOGICAL assay
KW - CEREAL products
KW - CEREALS as food
KW - FOLIC acid
KW - NEURAL tube -- Abnormalities
N1 - Accession Number: 16123833; DeVries, Jonathan W. 1; Email Address: jon.devries@genmills.com Rader, Jeanne I. 2 Keagy, Pamela M. 3 Hudson, Carol A. 3; Affiliation: 1: Medallion Laboratories, General Mills Inc., 90000 Plymouth Ave North, Minneapolis, MN 55427 2: U.S. Food and Drug Administration, Center for Food Safety and Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740-3835 3: U.S. Department of Agriculture, Western Regional Research Center, 800 Buchanan St, Albany, CA 94710; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p5; Subject Term: MICROBIOLOGICAL assay; Subject Term: BIOLOGICAL assay; Subject Term: CEREAL products; Subject Term: CEREALS as food; Subject Term: FOLIC acid; Subject Term: NEURAL tube -- Abnormalities; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lihong Hu
AU - Jin-Woo Jhoo
AU - Catharina Y. W. Ang
AU - Dinovi, Michael
AU - Mattia, Antonia
T1 - Determination of Six Kavalactones in Dietary Supplements and Selected Functional Foods Containing Piper methysticum by Isocratic Liquid Chromatography with Internal Standard.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 16
EP - 25
SN - 10603271
AB - Presents a study on the determination of six kavalactones in dietary supplements and selected functional foods containing piper methysticum by isocratic liquid chromatography. Worldwide sale of Kava dietary products for treatment of nervous anxiety, tension, and restlessness; Demonstration on the potential association of kava usage with liver injuries; Development of simple and reliable methodologies for the extraction and determination of of 6 major kavalactones.
KW - DIETARY supplements
KW - PIPER (Genus)
KW - KAVA plant
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - FUNCTIONAL foods
N1 - Accession Number: 16123834; Lihong Hu 1,2 Jin-Woo Jhoo 1 Catharina Y. W. Ang 1; Email Address: cang@nctr.fda.gov Dinovi, Michael 3 Mattia, Antonia 3; Affiliation: 1: U. S. Food and Drug Adminstration, National Center for Toxicological Research, Division of Chemistry, HFT-230, 3900 NCTR Rd, Jefferson, AR 72079 2: National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China 3: U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Biotechnology and GRAS Review, 5100 Paint Branch Pkwy, HFS-265, College Park, MD 20740; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p16; Subject Term: DIETARY supplements; Subject Term: PIPER (Genus); Subject Term: KAVA plant; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: FUNCTIONAL foods; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 10p; Illustrations: 1 Diagram, 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Douglas L.
AU - Coates, Scott
AU - Brewer, Vickery A.
AU - Garber, Eric A. E.
AU - Abouzied, Mohamed
AU - Johnson, Kurt
AU - Ritter, Bruce
AU - McKenzie, Deborah
T1 - Performance Tested MethodSM Multiple Laboratory Validation Study of ELISA-Based Assays for the Detection of Peanuts in Food.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 156
EP - 160
SN - 10603271
AB - Cites a study on the conduction of a Performance Tested Method multiple laboratory validations for the detection of peanut protein in different food matrixes. Validation of commercially available enzyme-linked immunoabsorbent assay (ELISA) test kits in the study; Ability of the commercially available test kits to identify spiked and peanut-free samples; Identification of peanuts as a common source for proteins.
KW - ENZYME-linked immunosorbent assay
KW - SOLID-phase analysis
KW - IMMUNOENZYME technique
KW - PEANUTS
KW - PEANUT products
KW - PROTEINS
KW - FOOD
N1 - Accession Number: 16123850; Park, Douglas L. 1; Email Address: dpark@cfsan.fda.gov Coates, Scott 2 Brewer, Vickery A. 1 Garber, Eric A. E. 1 Abouzied, Mohamed 3 Johnson, Kurt 4 Ritter, Bruce 5 McKenzie, Deborah 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Natural Products, 5100 Paint Branch Pkwy, College Park, MD 20740 2: AOAC Research Institute, 481 N. Frederick Ave, 4th Fl, Gaithersburg, MD 20877 3: Neogen Corp., 620 Lesher Pl, Lansing, MI 48912 4: R-Boppharm, Inc., 7950 Old U.S. 27 South, Marshall, MI 49068 5: ELISA Technologies, Inc., 4581-L NW 6th St, Gainesville, FL 32609; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p156; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: SOLID-phase analysis; Subject Term: IMMUNOENZYME technique; Subject Term: PEANUTS; Subject Term: PEANUT products; Subject Term: PROTEINS; Subject Term: FOOD; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111992 Peanut Farming; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whitaker, Thomas B.
AU - Williams, Kristina M.
AU - Trucksess, Mary W.
AU - Slate, Andrew B.
T1 - Immunochemical Analytical Methods for the Determination of Peanut Proteins in Foods.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 161
EP - 174
SN - 10603271
AB - Cites a study which sought to determine peanut proteins in foods though the use of immunochemical analytical methods. Ability of peanut proteins to cause allergenic reactions that can result in respiratory and circulatory effects in the body; Evaluation of the method performance of commercially available enzyme-linked immunosorbent assay (ELISA) kits for the detection of peanut proteins in milk, chocolate, ice cream, cookies, and breakfast cereals; Increase in the incidence and severity of allergic reactions to peanut proteins; Minimization of the risk of serious or fatal outcome by accidental consumption of peanut allergens; Potential of the commercial peanut detection kits to detect either peanuts or peanut proteins in various food matrixes.
KW - ENZYME-linked immunosorbent assay
KW - SOLID-phase analysis
KW - IMMUNOENZYME technique
KW - PEANUTS
KW - PEANUT products
KW - PROTEINS
KW - FOOD allergy
N1 - Accession Number: 16123851; Whitaker, Thomas B. 1; Email Address: tom_whitaker@ncsu.edu Williams, Kristina M. 2 Trucksess, Mary W. 2 Slate, Andrew B.; Affiliation: 1: U.S. Department of Agriculture, Agricultural Research Service, Box 7625, North Carolina State University, Raleigh, NC 27695–7625 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Rd, Laurel, MD 20708–2476; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p161; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: SOLID-phase analysis; Subject Term: IMMUNOENZYME technique; Subject Term: PEANUTS; Subject Term: PEANUT products; Subject Term: PROTEINS; Subject Term: FOOD allergy; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111992 Peanut Farming; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; Number of Pages: 14p; Illustrations: 1 Diagram, 10 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hungerford, James M.
T1 - Committee on Natural Toxins and Food Allergens.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 299
EP - 313
SN - 10603271
AB - Presents updates involving the AOAC Presidential Task Force on Marine and Freshwater Toxins in the U.S. Objectives of the task force; Total number of members in the task force; Meetings and conventions sponsored by the task force.
KW - ASSOCIATIONS, institutions, etc.
KW - ORGANIZATION
KW - ANALYTICAL chemistry
KW - TOXINS
KW - ALLERGENS
KW - ANTIGENS
N1 - Accession Number: 16123869; Hungerford, James M. 1; Email Address: James.Hungerford@fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Dr SE, Bothell, WA 98021; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p299; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: ORGANIZATION; Subject Term: ANALYTICAL chemistry; Subject Term: TOXINS; Subject Term: ALLERGENS; Subject Term: ANTIGENS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, Mary W.
T1 - Mycotoxins.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/01//Jan/Feb2005
VL - 88
IS - 1
M3 - Article
SP - 314
EP - 324
SN - 10603271
AB - Presents updates related to international organizations that focus on mycotoxins. Selection by the Harvey W. Wiley Selection Committee of AOAC International of Mary W. Trucksess as the recipient of the 2004 Harvey W. Wiley Award by AOAC Harvey W. Wiley Selection Committee for her significant contributions analytical method development of mycotoxins; Location of the 36th Codex Committee of Food Additives and Contaminants; Presentation of the methods approved by AOAC International as Official Final Action.
KW - ORGANIZATION
KW - ASSOCIATIONS, institutions, etc.
KW - MYCOTOXINS
KW - CONFERENCES & conventions
KW - SPECIAL events
KW - SPECIAL events -- Marketing
KW - AWARDS
N1 - Accession Number: 16123870; Trucksess, Mary W. 1; Email Address: mtruckse@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Jan/Feb2005, Vol. 88 Issue 1, p314; Subject Term: ORGANIZATION; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: MYCOTOXINS; Subject Term: CONFERENCES & conventions; Subject Term: SPECIAL events; Subject Term: SPECIAL events -- Marketing; Subject Term: AWARDS; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 711310 Promoters of Performing Arts, Sports, and Similar Events with Facilities; NAICS/Industry Codes: 711320 Promoters of Performing Arts, Sports, and Similar Events without Facilities; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scallet, Andrew C.
AU - Muskhelishvili, Levan
AU - Slikker, William
AU - Kadlubar, Fred F.
T1 - Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
Y1 - 2005/01//
VL - 29
IS - 1
M3 - Article
SP - 71
EP - 80
SN - 08910618
AB - Abstract: The metabolic enzyme CYP1B1 is a recently cloned member of the cytochrome P450 superfamily, expressed widely throughout primate tissue, including the CNS. Although CYP1B1 protein is known to metabolize estradiol to catecholestrogens in the uterus, its localization and function in brain have not yet been described. To better understand CYP1B1 distribution, we have combined in situ hybridization (ISH) for its mRNA with immunohistochemistry (IHC) for the CYP1B1 protein in selected brain regions of male and female adult rhesus monkeys (Macaca mulatta). Blocks of formalin-fixed tissue obtained from the frontal cortex, hippocampus, thalamus, and amygdala were processed and embedded in paraffin. They were then sectioned and stained as described for human tissue [Muskhelishvili, L., Thompson, P.A., Kusewitt, D.F., Wang, C., Kadlubar, F.F., 2001. In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues. J. Histochem. Cytochem. 49, 229–236]. Results indicated widespread distribution of CYP1B1 mRNA in both male and female monkey frontal cortex, hippocampus, thalamus, and amygdala. In contrast, although CYP1B1 protein was co-localized with its mRNA in the female brains, it was primarily restricted to hippocampal pyramidal neurons in the male brains. These results suggest that CYP1B1 may subserve widespread metabolic functions in the female primate brain but have more restricted actions within the hippocampal pyramidal neurons of the male. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chemical Neuroanatomy is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEX hormones
KW - RHESUS monkey
KW - IN situ hybridization
KW - SEX differences (Biology)
KW - Catecholestrogen
KW - Dopamine
KW - Estrogen
KW - Immunohistochemistry
KW - In situ hybridization
KW - Sex differences
N1 - Accession Number: 15585458; Scallet, Andrew C. 1; Email Address: ascallet@nctr.fda.gov Muskhelishvili, Levan 2 Slikker, William 1 Kadlubar, Fred F. 3; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, NCTR/FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA 2: Charles River Laboratories, NCTR/FDA, Jefferson, AR 72079, USA 3: Division of Molecular Epidemiology, NCTR/FDA, Jefferson, AR 72079, USA; Source Info: Jan2005, Vol. 29 Issue 1, p71; Subject Term: SEX hormones; Subject Term: RHESUS monkey; Subject Term: IN situ hybridization; Subject Term: SEX differences (Biology); Author-Supplied Keyword: Catecholestrogen; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Estrogen; Author-Supplied Keyword: Immunohistochemistry; Author-Supplied Keyword: In situ hybridization; Author-Supplied Keyword: Sex differences; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jchemneu.2004.09.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Steven B.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - Guest Editor's Preface
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 97
EP - 100
SN - 07479662
N1 - Accession Number: 0849346; Publication Type: Journal Article; Update Code: 200606
KW - Introductory Material Y20
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Cohen, Steven B.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - Integrated Survey Designs: A Framework for Nonresponse Bias Reduction
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 101
EP - 114
SN - 07479662
N1 - Accession Number: 0849347; Keywords: Health; Publication Type: Journal Article; Update Code: 200606
N2 - The quality and data content of household specific health surveys are often enhanced through integrated designs which include the conduct of follow back surveys to medical providers and facilities that have provided care to household respondents. In terms of data quality, household reported medical conditions can be evaluated for accuracy relative to provider specific records on medical conditions for the same patient and specific health events. With respect to health care expenditures collected from household respondents for their reported health care events, available linked medical provider level data is a more accurate source of information. The availability of such supplemental data on use and expenditures allows for the conduct of methodological studies to evaluate the accuracy of household reported data and informs adjustment strategies to household data in the absence of provider specific data to reduce bias attributable to response error. In this paper, the capacity of integrated survey designs to achieve reductions in bias attributable to survey nonresponse is discussed. Examples are drawn from the Medical Expenditure Panel Survey (MEPS), an ongoing longitudinal panel survey designed to produce estimates of health care utilization, expenditures, sources of payment, and insurance coverage of the U.S. civilian non-institutionalized population.
KW - Methodology for Collecting, Estimating, and Organizing Microeconomic Data; Data Access C81
KW - Health: General I10
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Cohen, Steven B.
AU - Wun, Lap-Ming
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - A Comparison of Household and Medical Provider Reported Health Care Utilization and an Estimation Strategy to Correct for Response Error
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 115
EP - 126
SN - 07479662
N1 - Accession Number: 0849348; Keywords: Health Care; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200606
N2 - In health care surveys similar to the MEPS, the use of additional administrative data and medical records for survey participants permits additional methodological investigations and evaluations to examine the accuracy of household reported data. When differentials are observed in the response profiles through these evaluations and comparisons, the design permits well specified adjustment and estimation strategies to correct for measurement error. In addition to serving as the primary source for the expenditures in the MEPS, the design of the Medical Provider Component provides data that could potentially facilitate adjustments to household reported utilization data that correct for reporting errors (both under-reporting and over-reporting (telescoping errors)), under the assumption that the medical provider reports are the gold standard. In this paper, we examine the level of concordance between household and medical provider utilization reports. An adjustment strategy to correct for response error attributable to household utilization reports is also presented.
KW - Health: General I10
KW - Analysis of Health Care Markets I11
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Yu, William W.
AU - Machlin, Steven R.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - An Examination of Skewed Health Expenditure Data from the Medical Expenditure Panel Survey (MEPS)
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 127
EP - 134
SN - 07479662
N1 - Accession Number: 0849349; Keywords: Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200606
N2 - The Medical Expenditure Panel Survey Household Component (MEPS-HC) is designed to provide nationally representative annual estimates of health care use, expenditures, sources of payment, and insurance coverage for the US civilian noninstitutionalized population. The expenditure data from MEPS have been shown to exhibit a marked positive skewness, with a few high expenditure respondents and many low or zero expenditure respondents. As a consequence of this departure from the normal distribution, the frequency with which a conventional confidence interval for a MEPS expenditure estimate will not capture the true population parameter may be higher than the probability stated for the confidence interval. Based on repeated sample simulations using data from the 1996 to 2001 MEPS-HC, this paper evaluates and compares the actual probability achieved for confidence intervals derived from expenditure data by types of expenditure and varying sample sizes. The results are also compared to estimated confidence probabilities obtained from repeated sample simulations for other types of variables that do not exhibit as marked a positive skewness as health care expenditures.
KW - Health: General I10
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Cohen, Steven B.
AU - Ezzati-Rice, Trena
AU - Yu, William
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - The Utility of Probabilistic Models to Identify Individuals with Future High Medical Expenditures
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 135
EP - 144
SN - 07479662
N1 - Accession Number: 0849350; Keywords: Health Care; Health; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200606
N2 - In this paper, an evaluation model is presented to assess the utility of probabilistic models in terms of their capacity to successfully oversample policy relevant population subgroups that are subject to transitions. Examples of these applications are drawn from the Medical Expenditure Panel Survey (MEPS). Given the high concentration of health care expenditures in a given year among a relatively small percentage of the population, a prediction model that can accurately identify the persistence of high levels of expenditures is an important analytical tool. This type of modeling effort also enhances the ability to discern the causes of high health care expenses and the characteristics of the individuals who incur them. This feature also applies to prediction models that can accurately identify those individuals with persistently low or average levels of expenditures. The models that are presented have particular relevance as statistical tools to facilitate efficient sampling strategies that permit the selection of an over-sample of individuals likely to incur high levels of medical expenditures in the future.
KW - Analysis of Health Care Markets I11
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Zuvekas, Samuel H.
AU - Cohen, Joel W.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - Trends in Provider Capitation, 1996-2000
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 145
EP - 156
SN - 07479662
N1 - Accession Number: 0849351; Keywords: Health Care; Health; Hospital; Hospitals; Physician; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200606
N2 - We examine the extent to which the health care services delivered by physicians and hospitals in public and private health plans are capitated, and how this changed from 1996 to 2000. The data are from the 1996 to 2000 years of the nationally representative Medical Expenditure Panel Survey (MEPS). Information on whether health care use was covered by capitated arrangements was obtained from billing offices of physicians and hospitals. We compare changes in the percentage of office-based physician visits, hospital outpatient department (OPD) visits, hospital emergency department (ED) visits, and hospital inpatient stays that are covered by capitation arrangements. We also compare differences by health insurance coverage and socio-demographic characteristics. We use standard two-tail tests of significance, accounting for the complex survey design of the MEPS. We find that only 15 percent of visits to office-based physicians were capitated in 1996, declining to 13 percent in 2000. Even among HMO enrollees, visits covered by a provider capitation arrangement represented a minority of all office visits, declining to 25 percent for Private HMO enrollees and 15 percent for Medicaid HMO enrollees in 2000. Even smaller proportions of hospital services were capitated. Conclusions: Capitation remains relatively rare even among public and private HMO enrollees.
KW - Analysis of Health Care Markets I11
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Eyerman, Joe
AU - Bowman, Katherine
AU - Butler, Dicy
AU - Wright, Douglas
AD - RTI International, Research Triangle Park, NC
AD - RTI International, Research Triangle Park, NC
AD - Substance Abuse and Mental Health Services Administration, Rockville, MD
AD - Substance Abuse and Mental Health Services Administration, Rockville, MD
T1 - The Differential Impact of Incentives on Refusals: Results from the 2001 National Household Survey on Drug Abuse Incentive Experiment
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 157
EP - 169
SN - 07479662
N1 - Accession Number: 0849352; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200606
N2 - Research has demonstrated that cash incentives paid to respondents in sample surveys can increase the level of cooperation, reduce non-response bias, and lower data collection costs. However, recent research has shown that gains in response rate and reduced data collection costs associated with monetary incentives may vary across sub-groups in the population. Consequently, monetary incentives may result in inconsistent reductions in non-response error and systemic changes in sample composition. This paper describes an incentive experiment conducted as part of the 2001 National Household Survey on Drug Abuse (NHSDA), and evaluates the impact of monetary incentives on measures of cooperation for different population sub-groups. Findings indicate that the incentive had a positive impact on cooperation. Furthermore, the incentive neither introduced additional differences in cooperation propensities, nor did it eliminate the pre-existing differences in cooperation among population sub-groups.
KW - Health: General I10
KW - Health Production I12
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Krenzke, Thomas
AU - Mohadjer, Leyla
AU - Ritter, Grant
AU - Gadzuk, Anita
AD - WESTAT, Rockville, MD
AD - WESTAT, Rockville, MD
AD - Schneider Institute for Health Policy, Brandeis U
AD - Substance Abuse and Mental Health Services Administration, Rockville, MD
T1 - Incentive Effects on Self-Report of Drug Use and Other Measures of Response Quality in the Alcohol and Drug Services Study
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2005///
VL - 30
IS - 2-3
SP - 191
EP - 217
SN - 07479662
N1 - Accession Number: 0849354; Keywords: Health; Substance Abuse; Publication Type: Journal Article; Update Code: 200606
N2 - The Alcohol and Drug Services Study (ADSS) was conducted for the Substance Abuse and Mental Health Services Administration between 1996 and 1999 to assess the nation's substance abuse treatment system. The sample for ADSS was selected using a multi-stage stratified design. Clients were sampled from selected substance abuse treatment facilities as part of the Phase II sample. Client follow-up comprised interviews and urine specimen collection in Phase III of the survey. One component of ADSS examined the impact of different incentive payments on measures of response rate and response quality using ADSS Phase III client interview data. To test for the effects of four payment levels, several measures of response quality were used. The analysis of consistency involving respondent self-reports, abstracted record data, and urine test results showed no conclusive evidence that incentive payments have any positive or negative effect on data consistency. The analysis of item non-response rates showed that an increase in incentive payments was associated with a subtle decrease in item type non-response rates. Furthermore, mixed results were observed when analyzing the relationship between incentive payment and clients reporting more (or less) of certain types of behavior.
KW - Health: General I10
KW - Health Production I12
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Seo, K. H.
AU - Brackett, R. E.
T1 - Rapid, Specific Detection of Enterobacter sakazakii in Infact Formula Using a Real-Time PCR Assay.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/01//
VL - 68
IS - 1
M3 - Article
SP - 59
EP - 63
SN - 0362028X
AB - Enterobacter sakazakii is a rare cause of invasive infection with high mortality rates in neonates. Powdered milk based infant formulas have been associated with the E. sakazakii-related outbreaks in premature or other immunocompromised infants. In this study, an assay was developed for the specific detection of E. sakazakii in infant formula using an application of the fluorogenic 5′ nuclease assay (TaqMan). A set of primers and probe was designed using the E. sakazakii partial macromolecular synthesis operon: the rpsU gene 3′ end and the primase (dnaG) gene 5′ end. The specificity of the assay was evaluated using 68 Enterobacter and 55 non-Enterobacter strains. The newly developed assay enables us to detect 100 CFU/ ml in pure culture and in reconstituted infant formula in 50 cycles of PCR without enrichment. The assay was specific enough to discriminate E. sakazakii from all other Enterobacter and non-Enterobacter strains tested. The developed real-time PCR assay could save up to 5 days and eliminate the need for plating samples on selective or diagnostic agars and for biochemical confirmation steps. The real-time PCR assay could be used to rapidly screen infant formula samples for E. sakazakii and would be a boon to food industries and regulatory agencies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Assaying
KW - Enterobacteriaceae
KW - Polymerase chain reaction
KW - Polymerization
KW - Enterobacter
KW - Newborn infants
KW - Infants
N1 - Accession Number: 15851149; Seo, K. H. 1; Email Address: kseo@cfsan.fda.gov; Brackett, R. E. 1; Affiliations: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy, Foods, and Beverages, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Jan2005, Vol. 68 Issue 1, p59; Thesaurus Term: Assaying; Thesaurus Term: Enterobacteriaceae; Subject Term: Polymerase chain reaction; Subject Term: Polymerization; Subject Term: Enterobacter; Subject Term: Newborn infants; Subject Term: Infants; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Edelson-Mammel, Sharon G.
AU - Whiting, Richard C.
AU - Joseph, Sam W.
AU - Buchanan, Robert L.
T1 - Effect of Prior Growth Conditions on the Thermal Inactivation of 13 Strains of Listeria monocytogenes in Two Heating Menstrua.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/01//
VL - 68
IS - 1
M3 - Article
SP - 168
EP - 172
SN - 0362028X
AB - The thermal tolerance of 13 Listeria monocytogenes strains was tested using a submerged heating coil apparatus. The strains were grown individually for 18 h at 37°C in acidogenic tryptic soy broth (without dextrose) supplemented with 1% glucose and 1% glutamine (TSB+G) or nonacidogenic tryptic soy broth supplemented with 1% glutamine but containing no glucose (dextrose) (TSB-G). The former medium results in cells induced for pH-dependent, stationary-phase acid resistance, whereas the latter medium allows L. monocytogenes to grow to high numbers in the absence of glucose, yielding cells that are not induced for pH-dependent, stationary-phase acid resistance. The average final pH values of the 18-h TSB+G and the TSB-G cultures were 4.7 and 6.7, respectively. The cells grown in the acid resistance-inducing and non-acid resis- tance-inducing media were then tested in two heating menstrua that consisted of brain heart infusion broth adjusted to pH 3.0 and water activity (aw) of 0.987 or pH 7.0 and aw 0.970. In 14 of the 26 menstruum-strain combinations tested, the acid resistance-induced strains were more heat resistant then the equivalent noninduced cultures. No difference in the pattern of thermal resistance in response to induction of acid resistance was apparent among the different serovars tested. The results suggest that the ability of prior induction of acid resistance to enhance thermal resistance can vary substantially among L. monocytogenes strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Listeria
KW - Food pathogens
KW - Gram-positive bacteria
KW - Nonfermented soyfoods
KW - Food science
KW - Listeria monocytogenes
N1 - Accession Number: 15851167; Edelson-Mammel, Sharon G. 1; Whiting, Richard C. 1; Joseph, Sam W. 2; Buchanan, Robert L. 1; Email Address: Robert.Buchanan@cfsan.fda.gov; Affiliations: 1: Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland; 2: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA; Issue Info: Jan2005, Vol. 68 Issue 1, p168; Thesaurus Term: Listeria; Thesaurus Term: Food pathogens; Thesaurus Term: Gram-positive bacteria; Thesaurus Term: Nonfermented soyfoods; Thesaurus Term: Food science; Subject Term: Listeria monocytogenes; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Isaacs, S.
AU - Aramini, J.
AU - Ciebin, B.
AU - Farrar, J. A.
AU - Ahmed, R.
AU - Middleton, D.
AU - Chandran, A. U.
AU - Harris, l. J.
AU - Howes, M.
AU - Chan, E.
AU - Pichette, A. S.
AU - Campbell, K.
AU - Gupata, A.
AU - Lior, L. Y.
AU - Pearce, M.
AU - Clark, C.
AU - Rodgers, F.
AU - Jamieson, F.
AU - Brophy, I.
AU - Ellis, A.
T1 - An International Outbreak of Salmonellosis Associated with Raw Almonds Contaminated with a Rare Phage Type of Salmonella Enteritidis.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/01//
VL - 68
IS - 1
M3 - Article
SP - 191
EP - 198
SN - 0362028X
AB - During the winter of 2000 to 2001, an outbreak due to Salmonella Enteritidis (SE) phage type 30 (PT30), a rare strain, was detected in Canada. The ensuing investigation involved Canadian and American public health and food regulatory agencies and an academic research laboratory. Enhanced laboratory surveillance, including phage typing and pulsed-field gel electro phoresis, was used to identify cases. Case questionnaires were administered to collect information about food and environmental exposures. A case-control study with 16 matched case-control pairs was conducted to test the hypothesis of an association between raw whole almond consumption and infection. Almond samples were collected from case homes, retail outlets, and the implicated processor, and environmental samples were collected from processing equipment and associated farms for microbiological testing. One hundred sixty-eight laboratory-confirmed cases of SE PT30 infection (157 in Canada, 11 in the United States) were identified between October 2000 and July 2001. The case-control study identified raw whole almonds as the source of infection (odds ration, 21.1; 95% confidence interval, 3.6 to ∞). SE PT30 was detected in raw whole natural almonds collected from home, retail, distribution, and warehouse sources and from environmental swabs of processing equipment and associated farmers' orchards. The frequent and prolonged recovery of this specific organism from a large agricultural area was an unexpected finding and may indicate significant diffuse contamination on these farms. Identification of almonds as the source of a foodborne outbreak is a previously undocumented finding, leading to a North American recall of this product and a review of current industry practices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food pathogens
KW - Food poisoning
KW - Foodborne diseases
KW - Food handling
KW - Food -- Safety measures
KW - Salmonella enteritidis
N1 - Accession Number: 15851172; Isaacs, S. 1; Email Address: sandy_isaacs@hc-sc.gc.ca; Aramini, J. 1; Ciebin, B. 2; Farrar, J. A. 3; Ahmed, R. 4; Middleton, D. 5; Chandran, A. U. 1,6; Harris, l. J. 7; Howes, M. 8; Chan, E. 5; Pichette, A. S. 9; Campbell, K. 8; Gupata, A. 10,11; Lior, L. Y. 6; Pearce, M. 12; Clark, C. 4; Rodgers, F. 4; Jamieson, F. 2; Brophy, I. 13; Ellis, A. 1; Affiliations: 1: Foodborne, Waterborne and Zoonotic Infections Division, Centre for Infectious Disease Prevention and Control, Health Canada, 160 Research Lane, Unit 206, Guelph, Ontario, Canada NIG 5B2; 2: Central Public Health Laboratory, Laboratories Branch, Ministry of Health and Lang-Term Care, Province of Ontario, 81 Resources Road, Ezobicoke, Ontario, Canada M9P 3T1; 3: Food and Drug Branch, California Department of Health Services, 601 North 7th Street, MS 357, P.O. Box 942732, Sacramento, CaIifornia 94234, USA; 4: National Laboratory of Enteric Pathogens, National Microbiology Laboratory, Health Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2; 5: Disease Control Service, Public Health Branch, Ministry of Health and Long-Term Care, Province of Ontario, 5700 Yonge Street, 8th Floor, Toronto, Ontario, Canada M2M 4K5; 6: Canadian Field Epidemiology Program, Population and Public Health Branch, Health Canada, 130 Colonnade Road, AL 6503A, Ottawa, Ontario, Canada KJA 0K9; 7: Department of Food Science and Technology, University of California, One Shields Avenue, Davis, California 95616, USA; 8: Canadian Food Inspection Agency, 3155 Willingdon Green, Burnaby, British Columbia, Canada V5G 4P2; 9: U.S. Food and Drug Administration, 5600 Fishers Lane, HFC-160 Room 12A55, Rockville, Maryland 20857, USA; 10: Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control, 1600 Clifton Road, MS-A -38, Atlanta, Georgia 30333, USA; 11: Foodborne and Diarrhea! Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, MS-C- 14, 1600 Clifton Road, MS-A- 38, Atlanta, Georgia 30333, USA; 12: Vancouver Island Health Authority, 2-2631 Quadra Street, Victoria, British Columbia, Canada V8T 4E2; 13: Provincial Epidemiology Service, Department of Health and Weilness, Province of New Brunswick, 520 King Street, 2nd Floor, Carleton Place, Fredericton, New Brunswick, Canada E3A 3N6; Issue Info: Jan2005, Vol. 68 Issue 1, p191; Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Food poisoning; Thesaurus Term: Foodborne diseases; Thesaurus Term: Food handling; Thesaurus Term: Food -- Safety measures; Subject Term: Salmonella enteritidis; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chamberlain, Paul
AU - Mire-Sluis, Anthony
T1 - Constructing an immunogenicity risk assessment for follow-on biologics.
JO - Journal of Generic Medicines
JF - Journal of Generic Medicines
Y1 - 2005/01//
VL - 2
IS - 2
M3 - Article
SP - 133
EP - 144
SN - 17411343
AB - The registration of follow-on biologics will depend on the availability of data demonstrating comparability with a reference product. It is recognised that measurement of relative immunogenicity will be an important component of the product comparability assessment. The way in which this is done will depend on a multidimensional risk-based approach that considers the probability of generating an immune response relative to the consequences of such a response. This paper presents principles and practical guidance for constructing a risk assessment, building on the experience gained for a variety of biopharmaceutical products. This includes the use of preclinical models and validated bioanalytical methods. Ultimately, postmarketing monitoring will be required to evaluate more fully the risk in representative settings, given the multifactorial nature of the potential immunogenicity of different therapeutic proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Generic Medicines is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - IMMUNOGENETICS
KW - GENETICS
KW - BIOLOGICALS
KW - CREDIT risk
KW - PROTEINS
KW - biogeneric
KW - biologic
KW - follow-on
KW - immunogeniciy
KW - regulatory
KW - risk
N1 - Accession Number: 15851353; Chamberlain, Paul 1; Email Address: paul.chamberlain@mdsps.com Mire-Sluis, Anthony 2; Affiliation: 1: Director of Biopharmaceuticals for the Drug Development Programs group of MDS Pharma Services. 2: Principal Advisor for Regulatory Science and Review,Office of Biotechnology Products, Center for Drug Evaluation and Research, FDA.; Source Info: Jan2005, Vol. 2 Issue 2, p133; Subject Term: RISK assessment; Subject Term: IMMUNOGENETICS; Subject Term: GENETICS; Subject Term: BIOLOGICALS; Subject Term: CREDIT risk; Subject Term: PROTEINS; Author-Supplied Keyword: biogeneric; Author-Supplied Keyword: biologic; Author-Supplied Keyword: follow-on; Author-Supplied Keyword: immunogeniciy; Author-Supplied Keyword: regulatory; Author-Supplied Keyword: risk; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106463260
T1 - Bridging the resource gap between underserved communities and HIV/AIDS care: the challenges and the commitments.
AU - Hopson DP
Y1 - 2005///Winter2005
N1 - Accession Number: 106463260. Language: English. Entry Date: 20060630. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9509701.
KW - Financing, Government
KW - Health Services
KW - HIV Infections -- Therapy
KW - Medically Underserved
KW - Acquired Immunodeficiency Syndrome -- Epidemiology
KW - Acquired Immunodeficiency Syndrome -- Mortality
KW - Cultural Competence
KW - Health Services Accessibility
KW - Health Services Needs and Demand
KW - HIV Infections -- Prevention and Control
KW - Minority Groups
KW - Primary Health Care
KW - United States
SP - 8
EP - 13
JO - Journal of Multicultural Nursing & Health (JMCNH)
JF - Journal of Multicultural Nursing & Health (JMCNH)
JA - J MULTICULT NURS HEALTH
VL - 11
IS - 1
CY - Houston, Texas
PB - Riley Publications
AB - OBJECTIVES: The Ryan White Comprehensive AIDS Resources Emergency (CARE) Act funds outpatient HIV/AIDS care for underserved individuals living in the United States. It is the largest HIV/AIDS-specific care program in the world. Representatives of organizations funded through the CARE Act met In Washington in August 2004 to address issues facing the HIV/AIDS care community and to learn more about effective care interventions, METHODS: At the opening plenary of the conference, Dr Deborah Parham Hopson, Associate Administrator for AIDS at the Health Resources and Services Administration (HRSA), the agency that administers the CARE Act, discussed the challenges facing the CARE Act community. RESULTS: Challenges include the growing HIV/AIDS prevalence, especially among minority and underserved communities; increasing demand for CARE Act-funded services; health care cost inflation; and the hundreds of thousands of people living with HIV/AIDS who are still not in care. CONCLUSIONS: After defining the challenges, Dr. Parham Hopson identified key principles for commitment to reducing the unequal burden of HIV/AIDS for underserved communities in the United States in the future. This paper presents an abridged version of Dr. Parham Hopson's address.
SN - 1526-8233
AD - U.S. Public Health Service, Health Resources and Services Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106583269
T1 - Sampling results of the improved SKC diesel particulate matter cassette.
AU - Noll JD
AU - Timko RJ
AU - McWilliams L
AU - Hall P
AU - Haney R
Y1 - 2005/01//
N1 - Accession Number: 106583269. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D4-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Equipment and Supplies
KW - Particulate Matter -- Evaluation
KW - Carbon
KW - Dust
KW - Education, Continuing (Credit)
KW - Human
SP - 29
EP - 37
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Diesel particulate matter (DPM) samples from underground metal/nonmetal mines are collected on quartz fiber filters and measured for carbon content using National Institute of Occupational Safety and Health Method 5040. If size-selective samplers are not used to collect DPM in the presence of carbonaceous ore dust, both the ore dust and DPM will collect on the quartz filters, causing the carbon attributed to DPM to be artificially high. Because the DPM particle size is much smaller than that of mechanically generated mine dust aerosols, it can be separated from the larger mine dust aerosol by a single-stage impactor. The SKC DPM cassette is a single-stage impactor designed to collect only DPM aerosols in the presence of carbonaceous mine ore aerosols, which are commonly found in underground nonmetal mines. However, there is limited data on how efficiently the SKC DPM cassette can collect DPM in the presence of ore dust. In this study we investigated the ability of the SKC DPM cassette to collect DPM while segregating ore dust from the sample. We found that the SKC DPM cassette accurately collected DPM. In the presence of carbon-based ore aerosols having an average concentration of 8 mg/m[3], no ore dust was detected on SKC DPM cassette filters. We did discover a problem: the surface areas of the DPM deposits on SKC DPM cassettes, manufactured prior to August 2002, were inconsistent. To correct this problem, SKC modified the cassette. The new cassette produced, with 99%confidence, a range of DPM deposit areas between 8.05 and 8.28 cm2, a difference of less than 3%.
SN - 1545-9624
AD - Pittsburgh Research Center, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Pittsburgh, PA 15236; jin1@cdc.gov
U2 - PMID: 15764521.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106583324
T1 - Reducing enclosed cab drill operator's respirable dust exposure with effective filtration and pressurization techniques.
AU - Cecala AB
AU - Organiscak JA
AU - Zimmer JA
AU - Heitbrink WA
AU - Moyer ES
AU - Schmitz M
AU - Ahrenholtz E
AU - Coppock CC
AU - Andrews EH
Y1 - 2005/01//
N1 - Accession Number: 106583324. Language: English. Entry Date: 20050218. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D4-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Dust -- Prevention and Control
KW - Pressure -- Methods
KW - Analysis of Covariance
KW - Analysis of Variance
KW - Education, Continuing (Credit)
KW - Quantitative Studies
KW - Regression
KW - Human
SP - 54
EP - 63
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Many different types of surface mining equipment use enclosed cabs to protect equipment operators from health and safety hazards. The overburden removal and mining process can be extremely dusty and can cause excessive dust exposure. To study this issue, a cooperative research effort was established between the National Institute for Occupational Safety and Health, U.S. Silica Co., Clean Air Filter Co., and Red Dot Corp. in an effort to lower respirable dust levels in an enclosed cab on an older surface drill at a silica sand operation. Throughout this research effort, a number of modifications were incorporated into the drill's filtration and pressurization system, as well as in other areas, to improve its design and performance. An average cab efficiency of 93.4% was determined with the gravimetric sampling instruments when comparing the outside with the inside cab dust levels on the final design. Although this study considered just one operation, the goal was to identify cost-effective improvements that could be implemented on all types of enclosed cabs to lower respirable dust concentrations. Two critical components for an effective enclosed cab system are having a properly designed, installed, and maintained filtration and pressurization system, along with a method for maintaining structural cab integrity, which allows the cab to be positively pressurized. Another important component is maintaining cab cleanliness. Although this research was originally directed toward the mining industry, it is also applicable to agricultural or construction equipment.
SN - 1545-9624
AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA; aic1@cdc.gov
U2 - PMID: 15764524.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - MANIPULATION VERSUS GRADED MOBILIZATION FOR TREATMENT OF MECHANICAL NECK DISORDERS. (Poster Session)
AU - Boyles, R.E.
AU - Walker, M.
AU - Young, B.
AU - Strunce, J.
AU - Wainner, R.
JO - Journal of Orthopaedic & Sports Physical Therapy
JF - Journal of Orthopaedic & Sports Physical Therapy
Y1 - 2005/01//
VL - 35
IS - 1
SP - A46
EP - A46
CY - ;
SN - 01906011
N1 - Accession Number: SPHS-970460; Author: Boyles, R.E.: 1 Author: Walker, M.: 2 Author: Young, B.: 3 Author: Strunce, J.: 4 Author: Wainner, R.: 5 ; Author Affiliation: 1 Physical Therapy, US Army-Baylor University, San Antonio, TX, USA; Physical Therapy, US Army Community Hospital, Ft Leonard Wood, MO, USA; Physical Therapy, US Air Force, Wilford Hall Medical Center, San Antonio, TX, USA; Physical Therapy, US Indian Health Service, Chinle, AZ, USA: 2 Physical Therapy, US Army-Baylor University, San Antonio, TX, USA; Physical Therapy, US Army Community Hospital, Ft Leonard Wood, MO, USA; Physical Therapy, US Air Force, Wilford Hall Medical Center, San Antonio, TX, USA; Physical Therapy, US Indian Health Service, Chinle, AZ, USA: 3 Physical Therapy, US Army-Baylor University, San Antonio, TX, USA; Physical Therapy, US Army Community Hospital, Ft Leonard Wood, MO, USA; Physical Therapy, US Air Force, Wilford Hall Medical Center, San Antonio, TX, USA; Physical Therapy, US Indian Health Service, Chinle, AZ, USA: 4 Physical Therapy, US Army-Baylor University, San Antonio, TX, USA; Physical Therapy, US Army Community Hospital, Ft Leonard Wood, MO, USA; Physical Therapy, US Air Force, Wilford Hall Medical Center, San Antonio, TX, USA; Physical Therapy, US Indian Health Service, Chinle, AZ, USA: 5 Physical Therapy, US Army-Baylor University, San Antonio, TX, USA; Physical Therapy, US Army Community Hospital, Ft Leonard Wood, MO, USA; Physical Therapy, US Air Force, Wilford Hall Medical Center, San Antonio, TX, USA; Physical Therapy, US Indian Health Service, Chinle, AZ, USA; No. of Pages: 1; Language: English; Parent Item: SPHP1980; General Notes: Orthopaedic section research abstracts: poster presentations.; Publication Type: Article; Material Type: PRINT; Update Code: 20060101; SIRC Article No.: S-970460
KW - *NECK
KW - *PAIN
KW - *BIOMECHANICS
KW - *THERAPEUTICS
KW - *MANIPULATION (Therapeutics)
KW - *MOTOR ability
KW - *EXERCISE
KW - *DRUGS -- Side effects
KW - METHODOLOGY
KW - COMPARATIVE studies
KW - ADULTHOOD
KW - EFFECTIVENESS
L2 - http://articles.sirc.ca/search.cfm?id=S-970460
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UR - http://articles.sirc.ca/search.cfm?id=S-970460
UR - http://www.apta.org/
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106127717
T1 - Rural-urban differences in employment-related health insurance.
AU - Larson SL
AU - Hill SC
Y1 - 2005/01//
N1 - Accession Number: 106127717. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Agency for Healthcare Research and Quality, Rockville, Maryland. NLM UID: 8508122.
KW - Health Services Accessibility
KW - Insurance, Health
KW - Medically Uninsured
KW - Rural Areas
KW - Urban Areas
KW - Adult
KW - Chi Square Test
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Health Services Accessibility -- Economics
KW - Insurance Benefits -- Economics
KW - Insurance, Health -- Economics
KW - Male
KW - Middle Age
KW - Regression
KW - Socioeconomic Factors
KW - Survey Research
KW - Time Factors
KW - Two-Tailed Test
KW - United States
KW - Human
SP - 21
EP - 30
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 21
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - CONTEXT: Rural residents are disproportionately represented among the uninsured in the United States. PURPOSE: We compared nonelderly adult residents in 3 types of nonmetropolitan areas with metropolitan workers to evaluate which characteristics contribute to lack of employment-related insurance. RESEARCH DESIGN AND ANALYSIS: Data were obtained from the Medical Expenditure Panel Survey, pooled across 3 panels (1996--1998) to enhance the rural sample size. Econometric decomposition was used to quantify the contribution of employment structure to differences in the probability of being offered employment-related health insurance. FINDINGS: The most rural workers are 10.4 percentage points less likely to be offered insurance compared with urban workers; the difference is smaller for residents of other rural areas. In rural counties not adjacent to urban areas, lower wages and smaller employers each account for about one-third of the total difference. CONCLUSIONS: Health insurance disparities associated with rural residence are related to the structure of employment. Major factors include smaller employers, lower wages, greater prevalence of self-employment, and sociodemographic characteristics.
SN - 0890-765X
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. slarson@ahrq.gov
U2 - PMID: 15667006.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106127717&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - JUNOD, SUZANNE WHITE
T1 - Review: Quacks & Crusaders: The Fabulous Careers of John Brinkley, Norman Baker, and Harry Hoxsey.
JO - Journal of the History of Medicine & Allied Sciences
JF - Journal of the History of Medicine & Allied Sciences
Y1 - 2005/01//
VL - 60
IS - 1
M3 - Book Review
SP - 116
EP - 118
SN - 00225045
AB - Reviewed: Quacks and Crusaders: The Fabulous Careers of John Brinkley, Norman Baker, and Harry Hoxsey. Juhnke, Eric S.
KW - QUACKS & quackery -- History
KW - NONFICTION
KW - RURAL geography
KW - QUACKS & quackery
KW - MEDICINE -- Practice
KW - MASS media
KW - colonial health
KW - decline of mortality
KW - Gibraltar
KW - military medicine
KW - Morbidity
KW - soldiers.
KW - Victorian British army
KW - Juhnke, Eric S.
KW - JUHNKE, Eric S.
KW - HOXSEY, Harry
KW - BRINKLEY, John Richard, 1885-1942
KW - BAKER, Norman, 1882-1958
KW - QUACKS & Crusaders: The Fabulous Careers of John Brinkley, Norman Baker & Harry Hoxsey (Book)
N1 - Accession Number: 44549342; JUNOD, SUZANNE WHITE 1; Affiliations: 1 : U.S. Food and Drug Administration, Rockville, Maryland 20857; Source Info: Jan2005, Vol. 60 Issue 1, p116; Note: Publication Information: Lawrence: U. Pr. of Kansas, 2002. 215 pp.; Historical Period: 1900 to 1949; Subject Term: QUACKS & quackery -- History; Subject Term: NONFICTION; Subject Term: RURAL geography; Subject Term: QUACKS & quackery; Subject Term: MEDICINE -- Practice; Subject Term: MASS media; Author-Supplied Keyword: colonial health; Author-Supplied Keyword: decline of mortality; Author-Supplied Keyword: Gibraltar; Author-Supplied Keyword: military medicine; Author-Supplied Keyword: Morbidity; Author-Supplied Keyword: soldiers.; Author-Supplied Keyword: Victorian British army; Number of Pages: 3p; Document Type: Book Review
L3 - 10.1093/jhmas/jri013
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Pieorsch, Walter W.
AU - West, R. Webster
AU - Pan, Wei
AU - Kodell, Ralpha L.
T1 - Low dose risk estimation via simultaneous statistical inferences.
JO - Journal of the Royal Statistical Society: Series C (Applied Statistics)
JF - Journal of the Royal Statistical Society: Series C (Applied Statistics)
Y1 - 2005/01//
VL - 54
IS - 1
M3 - Article
SP - 245
EP - 258
PB - Wiley-Blackwell
SN - 00359254
AB - The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as abench-mark dose) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Royal Statistical Society: Series C (Applied Statistics) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - CONFIDENCE intervals
KW - INFERENCE (Logic)
KW - CLINICAL trials
KW - ANIMAL experimentation
KW - ECOLOGY
KW - Bench-mark dose
KW - Environmental risk assessment
KW - Non-quantal dose--response
KW - Simultaneous confidence bands
KW - Simultaneous inference
N1 - Accession Number: 14798167; Pieorsch, Walter W. 1; Email Address: piegorsc@stat.sc.edu; West, R. Webster 1; Pan, Wei 2; Kodell, Ralpha L. 3; Affiliations: 1: University of South Carolina, Columbia, USA; 2: National Ocean Service, Charleston, USA; 3: National Center for Toxicological Research, Jefferson, USA; Issue Info: Jan2005, Vol. 54 Issue 1, p245; Thesaurus Term: RISK assessment; Subject Term: CONFIDENCE intervals; Subject Term: INFERENCE (Logic); Subject Term: CLINICAL trials; Subject Term: ANIMAL experimentation; Subject Term: ECOLOGY; Author-Supplied Keyword: Bench-mark dose; Author-Supplied Keyword: Environmental risk assessment; Author-Supplied Keyword: Non-quantal dose--response; Author-Supplied Keyword: Simultaneous confidence bands; Author-Supplied Keyword: Simultaneous inference; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 14p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1467-9876.2005.00481.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gao, G.
AU - Stuver, S. O.
AU - Okayama, A.
AU - Tsubouchi, H.
AU - Mueller, N. E.
AU - Tabor, E.
T1 - The minimum number of clones necessary to sequence in order to obtain the maximum information about hepatitis C virus quasispecies: a comparison of subjects with and without liver cancer.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005/01//
VL - 12
IS - 1
M3 - Article
SP - 46
EP - 50
PB - Wiley-Blackwell
SN - 13520504
AB - Most studies of hepatitis C virus (HCV) quasispecies have reported the results of sequencing only three to five clones per sample. The possibility that sequencing so few clones might not provide a representative picture of the quasispecies present in a sample has never been evaluated. The present study was conducted to evaluate whether sequencing greater numbers of clones results in better information about the HCV quasispecies number and distribution, and to compare the HCV quasispecies in liver cancer cases and controls. RNA was extracted from serial serum samples from six subjects with HCV-associated liver cancer and 11 age- and sex-matched HCV-infected controls without liver cancer. The hypervariable region 1 (HVR1) of the HCV genome was amplified, cloned, and sequenced. For further studies of 12 serum samples from two liver cancer cases and two matched controls, successive groups of 10 additional clones were sequenced up to a total of 50 clones per serum sample. When only 10 clones were sequenced from each specimen, no consistent differences were seen between the number of HCV quasispecies in the six liver cancer cases and the 11 controls. However, sequencing 40 clones from each of 12 samples from two liver cancer cases and two controls revealed a greater number of quasispecies in liver cancer cases than in controls. Testing an additional 10 clones (50 clones per sample) did not significantly increase the number of quasispecies detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C
KW - VIRAL hepatitis
KW - RNA
KW - LIVER -- Cancer
KW - SERUM
KW - LIVER diseases
KW - hepatitis C virus
KW - hepatoceliular carcinoma
KW - quasispecies
N1 - Accession Number: 15683877; Gao, G. 1 Stuver, S. O. 2,3 Okayama, A. 4 Tsubouchi, H. 4 Mueller, N. E. 2 Tabor, E. 1; Email Address: tabor@cber.fda.gov; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, MD, USA. 2: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. 3: Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. 4: Second Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan.; Source Info: Jan2005, Vol. 12 Issue 1, p46; Subject Term: HEPATITIS C; Subject Term: VIRAL hepatitis; Subject Term: RNA; Subject Term: LIVER -- Cancer; Subject Term: SERUM; Subject Term: LIVER diseases; Author-Supplied Keyword: hepatitis C virus; Author-Supplied Keyword: hepatoceliular carcinoma; Author-Supplied Keyword: quasispecies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1365-2893.2005.00546.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Richard J.
AU - Burgess, Ian F.
T1 - New head-lice treatments: hope or hype?
JO - Lancet
JF - Lancet
Y1 - 2005/01//1/1/2005
VL - 365
IS - 9453
M3 - Article
SP - 8
EP - 10
PB - Lancet
SN - 00995355
AB - Examines a possible new treatment for head lice. Increase in cases in developed countries which is suspected to be the result of increasing resistance to pyrethroid-based treatments; Examination of the lice which showed mutation in a region in the membrane of the nerve cell; Claims of Dale Pearlman who has a new product on the market; Dispute of the science behind the claims; Suspicion that the study used to make claims was written by Pearlman who holds the patents which therefore ruins any objectivity; Suggestion that the product is not ready for use; Advice on other ways to get rid of head lice.
KW - PEDICULOSIS
KW - LICE
KW - INSECTS
KW - PESTICIDE resistance
KW - MUTATION (Biology)
KW - INSECTICIDE resistance
KW - PATENT laws & legislation
KW - MARKETING
KW - PEARLMAN, Dale
N1 - Accession Number: 15535141; Roberts, Richard J. 1; Email Address: roberts@doctors.org.uk Burgess, Ian F. 2; Affiliation: 1: National Public Health Service for Wales, Mold, Flintshire CH7 1PZ, UK 2: Insect Research & Development Limited, Cambridge House, Shepreth, Royston, Hertfordshire, UK; Source Info: 1/1/2005, Vol. 365 Issue 9453, p8; Subject Term: PEDICULOSIS; Subject Term: LICE; Subject Term: INSECTS; Subject Term: PESTICIDE resistance; Subject Term: MUTATION (Biology); Subject Term: INSECTICIDE resistance; Subject Term: PATENT laws & legislation; Subject Term: MARKETING; NAICS/Industry Codes: 541613 Marketing Consulting Services; People: PEARLMAN, Dale; Number of Pages: 3p; Document Type: Article; Full Text Word Count: 1169
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106511967
T1 - New head-lice treatments: hope or hype?
AU - Roberts RJ
AU - Burgess IF
Y1 - 2005/01//1/1/2005
N1 - Accession Number: 106511967. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Lice Infestations -- Drug Therapy
KW - Child
KW - Drug Resistance
KW - Insecticides -- Therapeutic Use
KW - Lice
KW - Lice Infestations -- Diagnosis
KW - Lice Infestations -- Epidemiology
SP - 8
EP - 10
JO - Lancet
JF - Lancet
JA - LANCET
VL - 365 North American Edition
IS - 9453
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - National Public Health Service for Wales, Mold, Flintshire CH7 1PZ, UK; roberts@doctors.org.uk
U2 - PMID: 15639662.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rosen, Jennifer B.
AU - Breman, Joel G.
AU - Manclark, Charles R.
AU - Meade, Bruce D.
AU - Collins, William E.
AU - Lobel, Hans O.
AU - Saliou, Pierre
AU - Roberts, Jacquelin M.
AU - Campaoré, Pierre
AU - Miller, Mark A.
T1 - Malaria chemoprophylaxis and the serologic response to measles and diphtheria-tetanus-whole-cell pertussis vaccines.
JO - Malaria Journal
JF - Malaria Journal
Y1 - 2005/01//
VL - 4
M3 - Article
SP - 53
EP - 9
PB - BioMed Central
SN - 14752875
AB - Background: Acute malaria has been associated with a decreased antibody response to tetanus and diphtheria toxoids, meningococcal, salmonella, and Hib vaccines. Interest in giving malaria drug therapy and prevention at the time of childhood immunizations has increased greatly following recent trials of intermittent preventive therapy during infancy (IPTi), stimulating this re-analysis of unpublished data. The effect of malaria chemoprophylaxis on vaccine response was studied following administration of measles vaccines and diphtheria-tetanus-whole cell pertussis (DTP) vaccines. Methods: In 1975, six villages divided into two groups of children ≤74 months of age from Burkina Faso, were assigned to receive amodiaquine hydrochloride chemoprophylaxis (CH+) every two weeks for seven months or no chemoprophylaxis (CH-). After five months, children in each group received either one dose of measles or two doses of DTP vaccines. Results: For recipients of the measles vaccine, the seroconversion rates in CH+ and CH- children, respectively, were 93% and 96% (P > 0.05). The seroresponse rates in CH+ and CH- children respectively, were 73% and 86% for diphtheria (P > 0.05) and 77% and 91% for tetanus toxoid (P > 0.05). In a subset analysis, in which only children who strictly adhered to chemoprophylaxis criteria were included, there were, likewise, no significant differences in seroconversion or seroresponse for measles, diphtheria, or tetanus vaccines (P > 0.05). While analysis for pertussis showed a 43% (CH+) and 67% (CH-) response (P < 0.05), analyses using logistic regression to control for sex, age, chemoprophylaxis, weight-for-height Z-score, and pre-vaccination geometric mean titer (GMT), demonstrated that chemoprophylaxis was not associated with a significantly different conversion rate following DTP and measles vaccines. Seven months of chemoprophylaxis decreased significantly the malaria IFA and ELISA GMTs in the CH+ group. Conclusion: Malaria chemoprophylaxis prior to vaccination in malaria endemic settings did not improve or impair immunogenicity of DTP and measles vaccines. This is the first human study to look at the association between malaria chemoprophylaxis and the serologic response to whole-cell pertussis vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Malaria Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - PREVENTIVE medicine
KW - CHEMOPREVENTION
KW - IMMUNIZATION of children
KW - VIRUS diseases
N1 - Accession Number: 30095705; Rosen, Jennifer B. 1,2; Email Address: jennifer.rosen@uhmc.sunysb.edu Breman, Joel G. 1; Email Address: bremanj@ficod.fic.nih.gov Manclark, Charles R. 3; Email Address: crm@manclark.com Meade, Bruce D. 3; Email Address: meade@cber.FDA.gov Collins, William E. 4; Email Address: wec1@cdc.gov Lobel, Hans O. 4; Email Address: lobel@hargray.com Saliou, Pierre 5; Email Address: psaliou@pasteur.fr Roberts, Jacquelin M. 4; Email Address: JMR1@CDC.GOV Campaoré, Pierre; Email Address: traoreap@hotmail.com Miller, Mark A. 1; Email Address: millemar@mail.nih.gov; Affiliation: 1: Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. 2: Howard Hughes Medical Institute-National Institutes of Health Research Program, Bethesda, MD 20892, USA. 3: Division of Bacterial Products, Allergenic and Parasitic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. 4: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. 5: Société de Pathologie Exotique, Paris, France.; Source Info: 2005, Vol. 4, p53; Subject Term: VACCINATION; Subject Term: PREVENTIVE medicine; Subject Term: CHEMOPREVENTION; Subject Term: IMMUNIZATION of children; Subject Term: VIRUS diseases; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1186/1475-2875-4-53
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsai, Chen-An
AU - Lee, Te-Chang
AU - Ho, I-Ching
AU - Yang, Ueng-Cheng
AU - Chen, Chun-Houh
AU - Chen, James J.
T1 - Multi-class clustering and prediction in the analysis of microarray data
JO - Mathematical Biosciences
JF - Mathematical Biosciences
Y1 - 2005/01//
VL - 193
IS - 1
M3 - Article
SP - 79
EP - 100
SN - 00255564
AB - Abstract: DNA microarray technology provides tools for studying the expression profiles of a large number of distinct genes simultaneously. This technology has been applied to sample clustering and sample prediction. Because of a large number of genes measured, many of the genes in the original data set are irrelevant to the analysis. Selection of discriminatory genes is critical to the accuracy of clustering and prediction. This paper considers statistical significance testing approach to selecting discriminatory gene sets for multi-class clustering and prediction of experimental samples. A toxicogenomic data set with nine treatments (a control and eight metals, As, Cd, Ni, Cr, Sb, Pb, Cu, and AsV with a total of 55 samples) is used to illustrate a general framework of the approach. Among four selected gene sets, a gene set Ω I formed by the intersection of the F-test and the set of the union of one-versus-all t-tests performs the best in terms of clustering as well as prediction. Hierarchical and two modified partition (k-means) methods all show that the set Ω I is able to group the 55 samples into seven clusters reasonably well, in which the As and AsV samples are considered as one cluster (the same group) as are the Cd and Cu samples. With respect to prediction, the overall accuracy for the gene set Ω I using the nearest neighbors algorithm to predict 55 samples into one of the nine treatments is 85%. [Copyright &y& Elsevier]
AB - Copyright of Mathematical Biosciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - GENES
KW - HEREDITY
KW - NUCLEIC acids
KW - Bagged clustering
KW - Bagging fuzzy clustering
KW - Gene selection
KW - k-nn classification
KW - Rand statistic
KW - Shaded similarity matrix plot
N1 - Accession Number: 17344187; Tsai, Chen-An 1 Lee, Te-Chang 2,3 Ho, I-Ching 3 Yang, Ueng-Cheng 4 Chen, Chun-Houh 5 Chen, James J. 1; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration NCTR/FDA/HFT-20 Jefferson, AR 72079, USA 2: Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, 112 Taiwan 3: Institute of Biomedical Sciences, Academia Sinica, Taipei, 115 Taiwan 4: Institute of Biochemistry, National Yang-Ming University, Taipei, 112 Taiwan 5: Institute of Statistical Science, Academia Sinica, Taipei, 115 Taiwan; Source Info: Jan2005, Vol. 193 Issue 1, p79; Subject Term: DNA microarrays; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: NUCLEIC acids; Author-Supplied Keyword: Bagged clustering; Author-Supplied Keyword: Bagging fuzzy clustering; Author-Supplied Keyword: Gene selection; Author-Supplied Keyword: k-nn classification; Author-Supplied Keyword: Rand statistic; Author-Supplied Keyword: Shaded similarity matrix plot; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.mbs.2004.07.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106495393
T1 - Native American and Alaska Native health.
AU - Cooper D
A2 - Brown ML
Y1 - 2005/01//2005 Jan
N1 - Accession Number: 106495393. Language: English. Entry Date: 20050805. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Computer/Information Science; USA. NLM UID: 57810370R.
KW - Health Information
KW - Health Services, Indigenous
KW - Health Status
KW - Native Americans
KW - United States
KW - World Wide Web
SP - 7
EP - 7
JO - MLA News
JF - MLA News
JA - MLA NEWS
IS - 372
CY - Carol Stream, Illinois
PB - Medical Library Association
SN - 0541-5489
AD - Indian Health Service, Library, National Institutes of Health, Bethesda, MD
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UR - Related websites: www.uchsc.edu/ai/nehcrc/; www.4woman.gov/minority/native.htm; www.oneskycenter.org; americanindianhealth.nlm.nih.gov/intro/html; www.aap.org/nach/; diabetes.niddk.nih.gov/dm/pubs/americanindian/; www.ankn.uaf.edu/health.html; www.nal.usda.gov/outreach/Medicine.htm; www.kstrom.net/isk/food/foodmenu.html; hsc.unm.edu/library/nhd/links.cfm
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ménard, Cynthia
AU - Susil, Robert C.
AU - Choyke, Peter
AU - Coleman, Jonathan
AU - Grubb, Robert
AU - Gharib, Ahmed
AU - Krieger, Axel
AU - Guion, Peter
AU - Thomasson, David
AU - Ullman, Karen
AU - Gupta, Sandeep
AU - Espina, Virginia
AU - Liotta, Lance
AU - Petricoin, Emanuel
AU - Fitchtinger, Gabor
AU - Whitcomb, Louis L.
AU - Atalar, Ergin
AU - Coleman, C. Norman
AU - Camphausen, Kevin
T1 - An Interventional Magnetic Resonance Imaging Technique for the Molecular Characterization of Intraprostatic Dynamic Contrast Enhancement.
JO - Molecular Imaging
JF - Molecular Imaging
Y1 - 2005/01//
VL - 4
IS - 1
M3 - Article
SP - 63
EP - 66
PB - Sage Publications Inc.
SN - 15353508
AB - The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Imaging is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEOVASCULARIZATION
KW - MAGNETIC resonance imaging
KW - CANCER -- Magnetic resonance imaging
KW - TUMORS
KW - PROSTATE cancer
KW - Angiogenesis
KW - interventional MRI
KW - microarray analysis
KW - molecular imaging
KW - prostate cancer
N1 - Accession Number: 20056553; Ménard, Cynthia 1,2; Email Address: Cynthia.Menard@rmp.uhn.on.ca Susil, Robert C. 3 Choyke, Peter 1 Coleman, Jonathan 1 Grubb, Robert 1 Gharib, Ahmed 1 Krieger, Axel 3 Guion, Peter 1 Thomasson, David 1 Ullman, Karen 1 Gupta, Sandeep 4 Espina, Virginia 1 Liotta, Lance 1 Petricoin, Emanuel 5 Fitchtinger, Gabor 3 Whitcomb, Louis L. 3 Atalar, Ergin 3 Coleman, C. Norman 1 Camphausen, Kevin 1; Affiliation: 1: NIH/DHHS 2: University of Toronto 3: Johns Hopkins University 4: GE Healthcare Technologies 5: Food and Drug Administration; Source Info: Jan2005, Vol. 4 Issue 1, p63; Subject Term: NEOVASCULARIZATION; Subject Term: MAGNETIC resonance imaging; Subject Term: CANCER -- Magnetic resonance imaging; Subject Term: TUMORS; Subject Term: PROSTATE cancer; Author-Supplied Keyword: Angiogenesis; Author-Supplied Keyword: interventional MRI; Author-Supplied Keyword: microarray analysis; Author-Supplied Keyword: molecular imaging; Author-Supplied Keyword: prostate cancer; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - James, S.J.
AU - Slikker, William
AU - Melnyk, Stepan
AU - New, Elizabeth
AU - Pogribna, Marta
AU - Jernigan, Stefanie
T1 - Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2005/01//
VL - 26
IS - 1
M3 - Article
SP - 1
EP - 8
SN - 0161813X
AB - Thimerosol is an antiseptic containing 49.5% ethyl mercury that has been used for years as a preservative in many infant vaccines and in flu vaccines. Environmental methyl mercury has been shown to be highly neurotoxic, especially to the developing brain. Because mercury has a high affinity for thiol (sulfhydryl (
PB - Springer Science & Business Media B.V.
AB - OBJECTIVES: To examine the association between parental immigrant status and awareness of health and community resources to help address common family problems. METHODS: Using the 1999 National Survey of America's Families, a survey of the health, economic, and social characteristics of children and adults, bivariate and multivariate analyses were conducted on 35,938 children to examine the relationship between parents' immigrant status (U.S.-born citizens, naturalized citizens, and noncitizens) and their responses to questions about their awareness of specific health and community resources. RESULTS: Compared to U.S.-born citizens, noncitizens were at the highest risk of not being aware of health and community resources for most outcomes, followed by naturalized citizens. The services of which noncitizens were most likely to be unaware were places to get help for family discord, child care issues, and family violence. Multivariate analyses indicate that parental race/ethnicity, education level, employment status, and child age were other significant independent risk factors. CONCLUSIONS: Immigrant parents are at particularly high risk of alienation from systems of health care and support services that are available to low-income and other vulnerable populations in the United States. These findings clearly document disparate awareness among parents of different immigrant status. Community and health resources should reach out to immigrant populations, in linguistically and culturally appropriate ways, to alert them to the availability of their services.
SN - 1092-7875
AD - Maternal and Child Health Bureau, 5600 Fishers Lane, 18A-55, Rockville, MD 20857; syu@hrsa.gov
U2 - PMID: 15880972.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Laura J. Schild
AU - David H. Phillips
AU - Martin R. Osborne
AU - Alan Hewer
AU - Frederick A. Beland
AU - Mona I. Churchwell
AU - Karen Brown
AU - Margaret Gaskell
AU - Elizabeth Wright
AU - Miriam C. Poirier
T1 - Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2005/03//
VL - 20
IS - 2
M3 - Article
SP - 115
EP - 124
PB - Oxford University Press / USA
SN - 02678357
AB - Liver homogenates from rats fed tamoxifen (TAM) in the diet were shared among four different laboratories. TAMDNA adducts were assayed by high pressure liquid chromatographyelectrospray tandem mass spectrometry (HPLCES-MS/MS), TAMDNA chemiluminescence immunoassay (TAMDNA CIA), and 32P-postlabeling with either thin layer (32P-PTLC) or liquid chromatography (32P-PHPLC) separation. In the first study, rats were fed a diet containing 500 p.p.m. TAM for 2 months, and the values for measurements of the (E)-a-(deoxyguanosin-N2-yl)-tamoxifen (dG-N2-TAM) adduct in replicate rat livers varied by 3.5-fold when quantified using in house TAMDNA standards, or other approaches where appropriate. In the second study, rats were fed 0, 50, 250 or 500 p.p.m. TAM for 2 months, and TAMDNA values were quantified using both in house approaches as well as a newly synthesized [N-methyl-3H]TAMDNA standard that was shared among all the participating groups. In the second study, the total TAMDNA adduct values varied by 2-fold, while values for the dG-N2-TAM varied by 2.5-fold. Ratios of dG-N2-TAM:(E)-a-(deoxyguanosin-N2-yl)-N-desmethyltamoxifen (dG-N2-N-desmethyl-TAM) in the second study were ~1:1 over the range of doses examined. The study demonstrated a remarkably good agreement for TAMDNA adduct measurements among the diverse methods employed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Muridae
KW - Nucleic acids
KW - Antineoplastic agents
KW - Tamoxifen
N1 - Accession Number: 18468704; Laura J. Schild; David H. Phillips 1; Martin R. Osborne 1; Alan Hewer 1; Frederick A. Beland 2; Mona I. Churchwell 2; Karen Brown 3; Margaret Gaskell 3; Elizabeth Wright 3; Miriam C. Poirier 4; Affiliations: 1: ogenDNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC-4255, Bethesda, MD 20892-4255, USA, , 1 , Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey, SM2 5NG, UK,; 2: ogenDNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC-4255, Bethesda, MD 20892-4255, USA, , 1 , Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey, SM2 5NG, UK, , 2 , Division of Biochemical Toxicology, National Center for Toxicological Research, HFT-110, Jefferson, AR 72079, USA and; 3: ogenDNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC-4255, Bethesda, MD 20892-4255, USA, , 1 , Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey, SM2 5NG, UK, , 2 , Division of Biochemical Toxicology, National Center for Toxicological Research, HFT-110, Jefferson, AR 72079, USA and , 3 , Cancer Biomarkers and Prevention Group, The Biocentre, University of Leicester, Leicester LE1 7RH, UK; 4: ogenDNA Interactions Section, National Cancer Institute, Building 37, Room 4032 NIH, 37 Convent Drive MSC-4255, Bethesda, MD 20892-4255, USA, , 1 , Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey, SM2 5NG, UK, , 2 , Division of Biochemical Toxicology, National Center for Toxicological Research, HFT-110, Jefferson, AR 72079, USA and , 3 , Cancer Biomarkers and Prevention Group, The Biocentre, University of Leicester, Leicester LE1 7RH, UK, 4 , To whom correspondence should be addressed. Tel: +1 301-402-1835; Fax: +1 301-402-8230; Email: poirierm@exchange.nih.gov; Issue Info: Mar2005, Vol. 20 Issue 2, p115; Thesaurus Term: Muridae; Thesaurus Term: Nucleic acids; Subject Term: Antineoplastic agents; Subject Term: Tamoxifen; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - McGarrity, Lynda J.
AU - VonTungeln, Linda S.
AU - Mittelstaedt, Roberta A.
AU - Morris, Suzanne M.
AU - Beland, Frederick A.
AU - Heflich, Robert H.
T1 - Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2005/03//
VL - 570
IS - 2
M3 - Article
SP - 227
EP - 235
SN - 00275107
AB - Abstract: The first step in the activation of the anti-retroviral nucleoside analogue azidothymidine (AZT) involves its conversion to a 5′-monophosphate. In this study, we have evaluated the role of cytosolic thymidine kinase (Tk), the major enzyme involved in phosphorylating thymidine and its analogues, in the nuclear DNA damage produced by AZT in neonatal mice. Tk+/+, Tk+/- and Tk-/- mice were treated intraperitoneally with 200mg/kg/day of AZT on postnatal days 1 through 8, and micronuclei were measured in peripheral blood 24h after the last dose. AZT treatment increased the micronucleus (MN) frequencies to similar extents in both the reticulocytes (RETs) and normochromatic erythrocytes (NCEs) of Tk+/+ and Tk+/- mice; AZT did not increase the frequency of micronucleated RETs (MN-RETs) or micronucleated NCEs (MN-NCEs) in Tk-/- mice. Unexpectedly, neonatal Tk-/- mice treated with the vehicle had significantly elevated MN frequencies for both RETs and NCEs relative to Tk+/+ and Tk+/- mice (e.g., ∼3.4% MN-RETs and ∼4.8% MN-NCEs in Tk-/- mice versus ∼0.7 and ∼ 0.6% MN-RETs and MN-NCEs in neonatal Tk+/+ mice). Additional assays performed on untreated Tk-/- mice showed that elevated spontaneous MN frequencies persisted until at least 20 weeks of age, which approaches the average lifespan of Tk-/- mice. These results indicate that metabolism by Tk is necessary for the genotoxicity of AZT in neonatal mice; however, the genotoxicity of AZT is not altered by reducing the Tk gene dose by half. The elevated spontaneous MN frequencies in Tk-/- mice suggest the presence of an endogenous genotoxic activity in these mice. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROCYTES
KW - BLOOD cells
KW - AZT (Drug)
KW - MICE
KW - DNA damage
KW - Azidothymidine
KW - Erythrocyte frequency
KW - Micronucleus
KW - Nucleoside analog reverse-transcriptase inhibitor
KW - Pyrimidine metabolism
KW - Thymidine kinase
N1 - Accession Number: 16393906; Dobrovolsky, Vasily N. 1; Email Address: vdobrovolsky@nctr.fda.gov McGarrity, Lynda J. 1 VonTungeln, Linda S. 2 Mittelstaedt, Roberta A. 1 Morris, Suzanne M. 1 Beland, Frederick A. 2 Heflich, Robert H. 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration/National Center for Toxicological Research, HFT-120, 3900 NCTR Rd., Jefferson, AR 72079, USA 2: Division of Biochemical Toxicology, U.S. Food and Drug Administration/National Center for Toxicological Research, HFT-110, 3900 NCTR Rd., Jefferson, AR 72079, USA; Source Info: Mar2005, Vol. 570 Issue 2, p227; Subject Term: ERYTHROCYTES; Subject Term: BLOOD cells; Subject Term: AZT (Drug); Subject Term: MICE; Subject Term: DNA damage; Author-Supplied Keyword: Azidothymidine; Author-Supplied Keyword: Erythrocyte frequency; Author-Supplied Keyword: Micronucleus; Author-Supplied Keyword: Nucleoside analog reverse-transcriptase inhibitor; Author-Supplied Keyword: Pyrimidine metabolism; Author-Supplied Keyword: Thymidine kinase; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2004.11.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogge, Amy
AU - Slikker, William
T1 - Corrigendum to “Neuroimaging: New Approaches for Neurotoxicology” [NeuroToxicology 25 (4) (2004) 525–531]
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2005/03//
VL - 26
IS - 2
M3 - Correction notice
SP - 293
EP - 293
SN - 0161813X
N1 - Accession Number: 16392586; Pogge, Amy; Email Address: apogge@nctr.fda.gov Slikker, William 1; Affiliation: 1: National Center for Toxicological Research, Department of Neurotoxicology, HFT-132, 3900 NCTR Road Jefferson, AR, USA; Source Info: Mar2005, Vol. 26 Issue 2, p293; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.neuro.2003.10.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ferguson, Sherry A.
T1 - Report of the 28th Annual Meeting of the Neurobehavioral Teratology Society, 2004
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2005/03//
VL - 27
IS - 2
M3 - Article
SP - 311
EP - 312
SN - 08920362
N1 - Accession Number: 17426742; Ferguson, Sherry A. 1; Email Address: SFerguson@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, USA; Source Info: Mar2005, Vol. 27 Issue 2, p311; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.ntt.2005.01.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Meehye
T1 - High-methoxyl pectin has greater enhancing effect on glucose uptake in intestinal perfused rats
JO - Nutrition
JF - Nutrition
Y1 - 2005/03//
VL - 21
IS - 3
M3 - Article
SP - 372
EP - 377
SN - 08999007
AB - Abstract: Objective: Pectins have been known to decrease blood glucose levels. However, the mechanism of this effect is unclear. The direct action of various pectins (high- or low-methoxyl pectins) on the intestinal absorption of glucose was investigated in gut-perfused rats. Methods: After equilibrium, jejunal and ileal segments were simultaneously perfused with an isotonic electrolyte solution (pH 7.4) containing glucose (10 mM/L) and high- or low-methoxyl pectins (10 g/L). Each test or control solution was perfused in a random sequence, with perfusion times of 30 min. Changes in glucose concentration of perfusate solution reservoir were determined over the experimental period. Results: High- and low-methoxyl pectins in the perfusate significantly inhibited jejunal uptake of glucose compared with the control (P < 0.05). High-methoxyl pectins had greater inhibitive effect on intestinal absorption of glucose than low-methoxyl pectins. The observed changes in glucose and water absorptions caused by high- or low-methoxyl pectins were reversible by switching to a pectin-free perfusate. In addition, net water absorption changed to secretion after addition of high- or low-methoxyl pectins. Conclusions: These results suggest that the decrease in intestinal absorption of glucose observed after perfusion of high- or low-methoxyl pectins may be caused by viscosity-related increases in mucosal unstirred layer thickness. [Copyright &y& Elsevier]
AB - Copyright of Nutrition is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PECTINS
KW - BLOOD sugar
KW - SUGAR in the body
KW - GLUCOSE
KW - PERFUSION (Physiology)
KW - Glucose uptake
KW - High-methoxyl pectin
KW - Low-methoxyl pectin
KW - Rats
KW - Small intestine
N1 - Accession Number: 16837361; Kim, Meehye 1; Email Address: meehkim@kfda.go.kr; Affiliation: 1: Department of Risk Analysis, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Source Info: Mar2005, Vol. 21 Issue 3, p372; Subject Term: PECTINS; Subject Term: BLOOD sugar; Subject Term: SUGAR in the body; Subject Term: GLUCOSE; Subject Term: PERFUSION (Physiology); Author-Supplied Keyword: Glucose uptake; Author-Supplied Keyword: High-methoxyl pectin; Author-Supplied Keyword: Low-methoxyl pectin; Author-Supplied Keyword: Rats; Author-Supplied Keyword: Small intestine; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.nut.2004.07.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106477592
T1 - High-methoxyl pectin has greater enhancing effect on glucose uptake in intestinal perfused rats.
AU - Kim M
Y1 - 2005/03//
N1 - Accession Number: 106477592. Language: English. Entry Date: 20050708. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8802712.
KW - Dietary Fiber
KW - Intestinal Absorption
KW - Animal Studies
KW - Descriptive Statistics
KW - Experimental Studies
KW - Glucose -- Analysis
KW - Rats
KW - T-Tests
SP - 372
EP - 377
JO - Nutrition
JF - Nutrition
JA - NUTRITION
VL - 21
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - OBJECTIVE: Pectins have been known to decrease blood glucose levels. However, the mechanism of this effect is unclear. The direct action of various pectins (high- or low-methoxyl pectins) on the intestinal absorption of glucose was investigated in gut-perfused rats. METHODS: After equilibrium, jejunal and ileal segments were simultaneously perfused with an isotonic electrolyte solution (pH 7.4) containing glucose (10 mM/L) and high- or low-methoxyl pectins (10 g/L). Each test or control solution was perfused in a random sequence, with perfusion times of 30 min. Changes in glucose concentration of perfusate solution reservoir were determined over the experimental period. RESULTS: High- and low-methoxyl pectins in the perfusate significantly inhibited jejunal uptake of glucose compared with the control (P < 0.05). High-methoxyl pectins had greater inhibitive effect on intestinal absorption of glucose than low-methoxyl pectins. The observed changes in glucose and water absorptions caused by high- or low-methoxyl pectins were reversible by switching to a pectin-free perfusate. In addition, net water absorption changed to secretion after addition of high- or low-methoxyl pectins. CONCLUSIONS: These results suggest that the decrease in intestinal absorption of glucose observed after perfusion of high- or low-methoxyl pectins may be caused by viscosity-related increases in mucosal unstirred layer thickness.
SN - 0899-9007
AD - Dept of Risk Analysis, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; meehkim@kfda.go.kr
U2 - PMID: 15797681.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106460603
T1 - The dangers of drug importation.
AU - Nelson T
AU - Petropoulos JB
Y1 - 2005/03//2005 Mar
N1 - Accession Number: 106460603. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9015516.
KW - Consumer Product Safety
KW - Drugs, Prescription
KW - Fraud
KW - Product Acquisition
KW - Consumer Product Safety -- Education
KW - Drug Evaluation
KW - Health Education
KW - Internet
KW - Patient Safety
KW - Pharmaceutical Companies
KW - Pharmacy, Retail
KW - Product Labeling
KW - Product Packaging
KW - Professional Role
KW - Quality Assurance
KW - United States
KW - United States Food and Drug Administration
SP - 162
EP - 165
JO - P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management
JF - P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management
JA - P&T
VL - 30
IS - 3
CY - Yardley, Pennsylvania
PB - MediMedia Managed Markets, an ICON Company
AB - The authors review the reasons why drug importation is still prohibited.
SN - 1052-1372
AD - Drug Development Fellow, U.S. Food and Drug Administration's Center for Drug Evaluation and Research (CDER), Division of Drug Information, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106460607
T1 - An overview of the FDA's drug shortage program.
AU - Jensen V
AU - Kimzey R
AU - Saliba J
Y1 - 2005/03//2005 Mar
N1 - Accession Number: 106460607. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9015516.
KW - Drugs, Prescription -- Legislation and Jurisprudence -- United States
KW - Government Programs
KW - Health Services Needs and Demand
KW - United States Food and Drug Administration
KW - Health Care Delivery
KW - Health Resource Utilization
KW - Health Services Accessibility
KW - Pharmaceutical Companies
KW - Pharmacy, Retail
KW - Program Evaluation
KW - Program Implementation
KW - United States
SP - 174
EP - 177
JO - P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management
JF - P&T: A Peer-Reviewed Journal for Managed Care & Formulary Management
JA - P&T
VL - 30
IS - 3
CY - Yardley, Pennsylvania
PB - MediMedia Managed Markets, an ICON Company
AB - As members of The Drug Shortage Team, the authors describe the causes of and some solutions to drug shortfalls.
SN - 1052-1372
AD - Drug Shortage Program Project Manager, Drug Shortage Team, U.S. Food and Drug Administration's Center for Drug Evaluation and Research, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Amitai, Yona
AU - Haklai, Ziona
AU - Tarabeia, Jalal
AU - Green, Manfred S.
AU - Rotem, Naama
AU - Fleisher, Eve
AU - Leventhal, Alex
T1 - Infant mortality in Israel during 1950–2000: rates, causes, demographic characteristics and trends.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2005/03//
VL - 19
IS - 2
M3 - Article
SP - 145
EP - 151
PB - Wiley-Blackwell
SN - 02695022
AB - We evaluated the trends and risk factors in infant mortality in Israel over five decades (1950–2000), based on data obtained from the official notifications of live births, and death certificates. Until the 1960s the main cause of infant mortality was infectious disease; this was replaced by congenital anomalies in Moslems and Druzes, and preterm birth in Jews and Christians. In 2000, there were 746 infant deaths, and the national infant mortality rate (IMR) was 5.4 per 1000 live births (Jews 3.9;[95% CI 3.5, 4.3]; Moslems 9.2[8.3, 10.3]; Christians 3.6[1.4, 5.8]; Druzes 6.3[3.6, 9.0]). Between 1955 and 2000 the overall IMR declined sevenfold (absolute declines of 56.8, 56.3, 45.0 and 28.3 per 1000 live births, in Moslems, Druzes, Christians and Jews, respectively). The reduction in IMRs between 1990 and 2000 in all religious groups (>45%) exceeded the goal set by the World Summit for Children in 1990 of 33%. In 2000, the main risk factors were birthweight<1500 g[relative risk (RR) = 69], major congenital malformations (RR = 22.0[18.8, 25.7], and multiple births (RR of 9.3 and 4.2 in triplets and twins respectively). We conclude that the marked decline in IMRs in Israel over five decades reflects a major improvement in population health. Today, infant mortality in Israel represents a unique combination of high rate of congenital malformations among Moslems, where consanguineous marriages are common, and medical termination of pregnancy of malformed fetuses are infrequent; and relatively high IMRs from preterm birth in Jews, associated with high rates of assisted reproduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT mortality
KW - PERINATAL death
KW - HUMAN abnormalities
KW - SOCIAL indicators
KW - BIRTH weight
KW - REPRODUCTIVE technology
N1 - Accession Number: 16479770; Amitai, Yona 1; Email Address: YONA.AMITAI@MOH.HEALTH.GOVIL Haklai, Ziona 2 Tarabeia, Jalal 3 Green, Manfred S. 3 Rotem, Naama 4 Fleisher, Eve 1 Leventhal, Alex 5; Affiliation: 1: Department of Health Information, Jerusalem, Israel 2: Israeli Centre of Disease Control, Jerusalem, Israel 3: The Israeli Bureau of Statistics, Jerusalem, Israel 4: The Public Health Service, Ministry of Health, Jerusalem, Israel 5: Department of Mother, Child and Adolescent Health, Jerusalem, Israel; Source Info: Mar2005, Vol. 19 Issue 2, p145; Subject Term: INFANT mortality; Subject Term: PERINATAL death; Subject Term: HUMAN abnormalities; Subject Term: SOCIAL indicators; Subject Term: BIRTH weight; Subject Term: REPRODUCTIVE technology; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1365-3016.2005.00636.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shatin, Deborah
AU - Gardner, Jacqueline S.
AU - Stergachis, Andy
AU - Blough, David
AU - Graham, David
T1 - Impact of mailed warning to prescribers on the co-prescription of tramadol and antidepressants.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2005/03//
VL - 14
IS - 3
M3 - Article
SP - 149
EP - 154
SN - 10538569
AB - Purpose An evaluation was made of the effectiveness in changing prescribing behavior of 'Dear Health Professional (DHP)' letters mailed by the manufacturer to physicians and other health professionals advising them of safety information on co-prescribing of tramadol and antidepressants. Methods A retrospective cohort analysis of prescription claims of all plan members from 12 UnitedHealth Group-affiliated health plans who received a first prescription for tramadol between 1 April 1995 and 31 December 1996. The prevalence of co-prescribing of antidepressants and tramadol relative to the date of the 'DHP' communication was determined. Results 9218 plan members received an initial prescription for tramadol within the observation period. Prior to the date of the 'DHP' communication 1061/4774 (22.2%) members received a prescription for an antidepressant within 30 days of their first prescription for tramadol. Following the date of the communication 844/4444 (19.0%) of members received an antidepressant within 30 days of their first prescription for tramadol. An overall decreasing linear trend in antidepressant co-prescribing was evident over the observation period, but there was no statistically significant acceleration in the decrease following this communication. Conclusions The mailed 'DHP' advisory letter did not affect the rate of co-prescribing of tramadol with antidepressants. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709612; Shatin, Deborah 1; Gardner, Jacqueline S. 2; Stergachis, Andy 3; Blough, David 2; Graham, David 4; Affiliations: 1: Center for Health Care Policy and Evaluation, UnitedHealth Group, Minneapolis, MN, USA; 2: Department of Pharmacy, University of Washington, Seattle, WA, USA; 3: Department of Epidemiology, University of Washington, Seattle, WA, USA; 4: U.S. Food and Drug Administration, Rockville, MD, USA; Issue Info: Mar2005, Vol. 14 Issue 3, p149; Number of Pages: 6p; Document Type: Article
L3 - 10.1002/pds.961
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Governale, Laura A.
T1 - Use of menopausal hormones in the United States, 1992 through June, 2003.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2005/03//
VL - 14
IS - 3
M3 - Article
SP - 171
EP - 176
SN - 10538569
AB - Purpose The Women's Health Initiative (WHI) study that documented an unfavorable benefit to risk ratio of Prempro and subsequently an increased risk of stroke with menopausal estrogen prompted us to investigate the use during 1992 through June 2003 of menopausal hormones in the United States. Methods Two pharmaceutical research databases from IMS Health, the National Prescription Audit Plus™ and the National Disease and Therapeutic Index™, were accessed and analyzed. Results The number of dispensed outpatient prescriptions for oral menopausal estrogens and oral combination estrogen-progestins increased 2.5-fold (153%) from 34.5 million dispensed in 1992 to a high of 87.3 million in 2000. For July 2002 through June 2003, the year following the publication of the results of the WHI trial, prescriptions for these products declined to 59.6 million, a 32% decrease from their peak in 2000. Prescriptions for transdermal estrogen and transdermal combination estrogen-progestin products increased from 5.2 million dispensed in 1992 to their peak of 8.3 million in 2000, and declined 10% to 7.5 million during July 2002 through June 2003. By contrast, prescriptions for oral menopausal progestins rose to 17.5 million in 1995 and then steadily declined. In the year after the WHI, prescriptions for oral progestins decreased 49% to 8.9 million from their peak in 1995. The earlier decline in oral progestin prescriptions was primarily due to the marketing in 1995 of the popular oral combination estrogen-progestin drugs. Conclusions Prescriptions dispensed for menopausal hormones increased substantially between 1992 and peaked in 2000. By June 2003, prescriptions for oral menopausal estrogens and oral combination estrogen-progestins had declined by about one-third from their peak year. Published in 2004 by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709620; Wysowski, Diane K. 1; Governale, Laura A. 1; Affiliations: 1: Office of Drug Safety, Food and Drug Administration, Rockville, MD, USA; Issue Info: Mar2005, Vol. 14 Issue 3, p171; Number of Pages: 6p; Document Type: Article
L3 - 10.1002/pds.985
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Daniels, R. D.
AU - Schubauer-Berigan, M. K.
T1 - BIAS AND UNCERTAINTY OF PENETRATING PHOTON DOSE MEASURED BY FILM DOSEMETERS IN AN EPIDEMIOLOGICAL STUDY OF US NUCLEAR WORKERS.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2005/03//
VL - 113
IS - 3
M3 - Article
SP - 275
EP - 289
SN - 01448420
AB - A retrospective exposure assessment of 1269 study subjects was completed for use in a multi-site case-control study of the relationship between protracted workplace external radiation exposure and leukaemia mortality. The majority of exposure data result from film badge monitoring programmes at the four US weapons production facilities and a US Naval shipyard. Bias and uncertainty in reported exposures among study facilities and across lime were as result of differences in incident photon energy, exposure geometry, dosemeter type and dosimetry methods. These sources of measurement uncertainty were examined by facility and lime to derive bias factors (B) for normalising exposures. In conjunction with facility reported results, the bias factors provide a means to estimate the equivalent dose, penetrating to a depth of 10 mm [Hp(10)] and the equivalent dose to the active bone marrow for use in the epidemiological study. Uncertainty was expressed as the constructed 95% confidence interval (i.e. the 2.5th-97.5th% range) of the estimated parameter. The bias factors indicate that recorded exposures provide a reasonable estimate of Hp(10) (bias factor near unity) and overestimate equivalent dose to active bone marrow (HT) by a factor between 1.2 and 1.7. On average, dosemeter-response uncertainties estimated using Monte Carlo simulation were approximately ±19 and ±33% for Hp(10) and HT, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Nuclear energy
KW - Radiation
KW - Photons
KW - Immune system
KW - Work environment
N1 - Accession Number: 18069439; Daniels, R. D. 1; Email Address: RTD2@CDC.gov; Schubauer-Berigan, M. K. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), 555 Ridge Avenue, R-44, Cincinnati, OH 45213, USA.; Issue Info: 2005, Vol. 113 Issue 3, p275; Thesaurus Term: Epidemiology; Thesaurus Term: Nuclear energy; Thesaurus Term: Radiation; Subject Term: Photons; Subject Term: Immune system; Subject Term: Work environment; NAICS/Industry Codes: 221113 Nuclear Electric Power Generation; Number of Pages: 15p; Document Type: Article
L3 - 10.1093/rpd/nch470
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Chen, Chen-Peng
AU - Sartorelli, Pietro
T1 - Proceedings of the international conference on occupational and environmental exposures of skin to chemicals: science and policy—session II: health effects and hazard identification
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/03//
VL - 41
IS - 2
M3 - Proceeding
SP - 150
EP - 158
SN - 02732300
N1 - Accession Number: 17344276; Chen, Chen-Peng 1; Email Address: CChen1@cdc.gov; Sartorelli, Pietro 2; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA; 2: Occupational Medicine Institute, University of Siena, Siena, Italy; Issue Info: Mar2005, Vol. 41 Issue 2, p150; Number of Pages: 9p; Document Type: Proceeding
L3 - 10.1016/j.yrtph.2004.10.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matheson, Joanna M.
AU - Johnson, Victor J.
AU - Vallyathan, Velayudhan
AU - Luster, Michael I.
T1 - Exposure and Immunological Determinants in a Murine Model for Toluene Diisocyanate (TDI) Asthma.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/03//
VL - 84
IS - 1
M3 - Article
SP - 88
EP - 98
PB - Oxford University Press / USA
SN - 10966080
AB - Isocyanate-induced asthma, the most commonly reported cause of occupational asthma, has been difficult to diagnose and control, in part, because the biological mechanisms responsible for the disease and the determinants of exposure have been difficult to define. Appropriate animals models of isocyanate asthma will be instrumental to further our understanding of this disease. Previous studies have demonstrated that dermal exposure to isocyanates in mice results in systemic sensitization that leads to eosinophilic airways inflammation upon subsequent airway challenge. We hypothesized that inhalation of vapor phase toluene diisocyante (TDI) will lead to immunologic sensitization in mice and that subsequent challenge will induce pathology and immune system alterations indicative of asthma found in humans. To determine the impact of exposure dose as well as the involvement of immune (allergic) or nonimmune mechanisms, a murine model of TDI asthma was established and characterized following either low-level subchronic or high-dose acute inhalation TDI exposure. C57BL/6 J mice were exposed to TDI by inhalation either subchronically for 6 weeks (20 ppb, 4 h/day, 5 days/week) or by a 2-h acute exposure at 500 ppb. Both groups were challenged 14 days later via inhalation with 20 ppb TDI for 1 h. Mice that underwent the subchronic exposure regimen demonstrated a marked allergic response evidenced by increases in airway inflammation, eosinophilia, goblet cell metaplasia, epithelial cell alterations, airway hyperreponsiveness (AHR), TH1/TH2 cytokine expression in the lung, elevated levels of serum IgE, and TDI-specific IgG antibodies, as well as the ability to transfer these pathologies to naïve mice with lymphocytes or sera from TDI exposed mice. In contrast, mice that received acute TDI exposure demonstrated increased AHR, specific IgG antibodies, and pathology in the lung consistent with asthma, but without the presence of elevated serum IgE, lung eosionophilia, or increased expression of TH cytokines. These results describe mouse models for TDI asthma consistent with that found in workers with occupational asthma and indicate that the pulmonary pathology associated with TDI can vary depending upon the exposure paradigm. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toluene diisocyanate
KW - Asthma
KW - Immunology
KW - Mice as laboratory animals
KW - Pulmonary toxicology -- Animal models
KW - isocyanate-induced asthma
KW - lymphocytes
KW - toluene diisocyanate
N1 - Accession Number: 44406514; Matheson, Joanna M. 1; Johnson, Victor J. 1; Vallyathan, Velayudhan 2; Luster, Michael I. 1; Email Address: mluster@cdc.gov; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Mar2005, Vol. 84 Issue 1, p88; Thesaurus Term: Toluene diisocyanate; Thesaurus Term: Asthma; Thesaurus Term: Immunology; Subject Term: Mice as laboratory animals; Subject Term: Pulmonary toxicology -- Animal models; Author-Supplied Keyword: isocyanate-induced asthma; Author-Supplied Keyword: lymphocytes; Author-Supplied Keyword: toluene diisocyanate; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi050
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matheson, Joanna M.
AU - Johnson, Victor J.
AU - Luster, Michael I.
T1 - Immune Mediators in a Murine Model for Occupational Asthma: Studies with Toluene Diisocyanate.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/03//
VL - 84
IS - 1
M3 - Article
SP - 99
EP - 109
PB - Oxford University Press / USA
SN - 10966080
AB - Isocyanate-induced asthma, which is the most common type of occupational asthma, has been difficult to diagnose and control, in part, because the biological mechanisms responsible for the disease and the determinants of exposure are not fully defined. To help address these issues, we recently established a murine model of toluene diisocyanate (TDI) asthma using inhalation exposure paradigms consistent with potential workplace exposure. In order to confirm our hypothesis that TDI-induce asthma, like allergic asthma, is predominantly a Th2 response, the ability of mice that were deficient in CD4 or CD8 cells or specific Th1 and Th2 cytokines to develop TDI asthma was examined. The development of allergic asthma was evaluated by monitoring lungs for the presence of eosinophilia, goblet cell metaplasia, epithelial cell alterations, airway hyperreactivity (AHR), and Th2 and Th1 cytokine expression, as well as serum IgE levels and TDI-specific IgG antibodies. Transgenic CD8 or CD4 knockout (KO) mice exhibited significant reductions in AHR, cytokine expression, serum antibody levels, airway inflammation, and histopathological lesions, although in a number of the endpoints the effects were more attenuated in CD4 KO mice. IFNγ depletion ablated the increase in AHR in TDI-allergic mice, but had only slight to moderate effects on airway histopathology, serum antibody levels, and cytokine expression compared to sensitized/challenged controls. IL-4 and IL-13 deficiency had moderate inhibitory effects, while combined IL-4/IL-13 depletion effectively prevented almost all asthma-associated pathologies. Taken together, these results indicate that TDI asthma, like immune-mediated asthma produced by large-molecular-weight materials, is driven primarily by CD4+ T cells and is dependent upon the expression of Th2 cytokines. However, as with protein-induced asthma models, certain pathologies are influenced by CD8+ T cells and Th1-derived cytokines, such as AHR and cytokine production. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Toluene diisocyanate
KW - Occupational diseases
KW - Isocyanates
KW - Mice as laboratory animals
KW - airway hyperreactivity
KW - cytokines
KW - isocyanate-induced asthma
KW - occupational asthma
KW - toluene diisocyanate
N1 - Accession Number: 44406513; Matheson, Joanna M. 1; Johnson, Victor J. 1; Luster, Michael I. 1; Email Address: mluster@cdc.gov; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Mar2005, Vol. 84 Issue 1, p99; Thesaurus Term: Asthma; Thesaurus Term: Toluene diisocyanate; Thesaurus Term: Occupational diseases; Subject Term: Isocyanates; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: airway hyperreactivity; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: isocyanate-induced asthma; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: toluene diisocyanate; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi051
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frasch, H. Fred
AU - Barbero, Ana M.
T1 - Application of solid-phase microextraction to in vitro skin permeation experiments: example using diethyl phthalate
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2005/03//
VL - 19
IS - 2
M3 - Article
SP - 253
EP - 259
SN - 08872333
AB - Abstract: The application of automated solid-phase microextraction (SPME) as a sample preparation technique for in vitro studies of skin permeation is described, using diethyl phthalate (DEP) as an example. In vitro diffusion cell experiments and skin–vehicle partition coefficient determinations require quantitative analysis of low-level analytes in aqueous samples. SPME is an ideal candidate for sample preparation for subsequent gas chromatographic analysis, offering numerous advantages over other methods. SPME conditions were optimized and the automated method was found to exhibit adequate sensitivity and good precision (relative standard deviation=3%). Abdominal skin (dermatomed at 350μm) from male hairless guinea pigs (n=6) was used to measure DEP skin permeation parameters. In vitro methods were employed to determine permeability coefficient (kp), time lag (τ) and skin–buffer partition coefficient (KSB) for 2mM DEP in HEPES buffered Hanks Balanced Salt Solution. Measurements (mean±standard deviations) are: kp, 0.021±0.012cm/h; τ, 0.67±0.18h; KSB, 4.74±0.68. The skin may be a significant route for the uptake of DEP. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERMEABILITY
KW - Diethylhexyl phthalate
KW - Guinea pigs
KW - Chromatographic analysis
KW - Skin
KW - Gas chromatography methods
KW - Membrane vehicle partition coefficient
KW - Permeability
KW - Phthalic acid diesters
KW - Time lag
N1 - Accession Number: 22229872; Frasch, H. Fred; Email Address: hbf9@cdc.gov; Barbero, Ana M. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Mar2005, Vol. 19 Issue 2, p253; Thesaurus Term: PERMEABILITY; Thesaurus Term: Diethylhexyl phthalate; Thesaurus Term: Guinea pigs; Thesaurus Term: Chromatographic analysis; Subject Term: Skin; Author-Supplied Keyword: Gas chromatography methods; Author-Supplied Keyword: Membrane vehicle partition coefficient; Author-Supplied Keyword: Permeability; Author-Supplied Keyword: Phthalic acid diesters; Author-Supplied Keyword: Time lag; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.tiv.2004.10.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Savage Jr., R. E.
AU - Kanitz, M. H.
AU - Lotz, W. G.
AU - Conover, D.
AU - Hennessey, E. M.
AU - Hanneman, W. H.
AU - Witzmann, F. A.
T1 - Changes in Gene and Protein Expression in Magnetic Field–Treated Human Glioma Cells.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2005/03//Mar/Apr2005
VL - 15
IS - 2
M3 - Article
SP - 115
EP - 120
PB - Taylor & Francis Ltd
SN - 15376516
AB - Because few cancer studies have examined protein profiles and genetic regulation from a single carcinogen exposure, the objective of this study was to determine genetic change via microarray and to evaluate whether that change was a precursor to cellular protein changes. In separate but experimentally identical studies, human glioma SF767 cells were exposed for 3 h to 60-Hz magnetic fields (sham or 1.2 µT). Microarray results suggested that magnetic field treatment resulted in the up-regulation of 5 genes, whereas 25 genes were down-regulated. The mean abundance of 10 identified proteins was altered following 1.2 µT exposure relative to sham (3 increase, 7 decrease). These studies suggest a limited but complicated response in the glioma cells to the magnetic field treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLIOMAS
KW - PROTEINS
KW - GENETIC regulation
KW - GENOMICS
KW - MAGNETIC fields
KW - PROTEOMICS
KW - DNA microarrays
KW - TOXICOLOGY
KW - Genomics
KW - Glioma
KW - Magnetic Field
KW - Proteomics
N1 - Accession Number: 17121656; Savage Jr., R. E. 1; Email Address: ras6@cdc.gov Kanitz, M. H. 1 Lotz, W. G. 1 Conover, D. 1 Hennessey, E. M. 2 Hanneman, W. H. 2 Witzmann, F. A. 3; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio 45226 2: Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 3: Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202; Source Info: Mar/Apr2005, Vol. 15 Issue 2, p115; Subject Term: GLIOMAS; Subject Term: PROTEINS; Subject Term: GENETIC regulation; Subject Term: GENOMICS; Subject Term: MAGNETIC fields; Subject Term: PROTEOMICS; Subject Term: DNA microarrays; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Genomics; Author-Supplied Keyword: Glioma; Author-Supplied Keyword: Magnetic Field; Author-Supplied Keyword: Proteomics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/15376520590918829
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Di Pentima, M . C.
AU - Steele-Moore, L.
AU - Muehlbauer, L.
AU - Klein, J . D.
T1 - Are your patients at risk? Fungal contamination of Ilex paraguariensis St. Hil (yerba maté).
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
Y1 - 2005/03//
VL - 7
IS - 1
M3 - Letter
SP - 47
EP - 48
PB - Wiley-Blackwell
SN - 13982273
AB - Presents a letter to the editor in response to the article "Are Your Patients at Risk? Fungal Contamination of Ilex paraguariensis St. Hil (yerba maté)," that was previously published in the journal "Transplant Infectious Diseases."
KW - LETTERS to the editor
KW - DISEASES
KW - fungal contamination
KW - Ilex paraguariensis St. Hil
KW - yerba maté
KW - yerba maté
N1 - Accession Number: 17466036; Di Pentima, M . C. 1,2; Email Address: cdipenti@nemours.org Steele-Moore, L. 3,4 Muehlbauer, L. 3 Klein, J . D. 1,2; Affiliation: 1: Nemours Children’s Clinic-Wilmington, Alfred I. duPont Hospital for Children, Department of Pediatric, Infectious Disease Section, Wilmington, Delaware, USA 2: Infectious Disease Section, Department of Pediatric, Thomas Jefferson University, Philadelphia, Pennsylvania, USA 3: Christiana Care Health System, Newark, Delware, USA 4: Food and Drug Administration, Rockville, Maryland, USA; Source Info: Mar2005, Vol. 7 Issue 1, p47; Subject Term: LETTERS to the editor; Subject Term: DISEASES; Author-Supplied Keyword: fungal contamination; Author-Supplied Keyword: Ilex paraguariensis St. Hil; Author-Supplied Keyword: yerba maté; Author-Supplied Keyword: yerba maté; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1399-3062.2005.00085.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17466036&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dionne, Raymond A.
AU - Bartoshuk, Linda
AU - Mogil, Jeffrey
AU - Witter, James
T1 - Individual responder analyses for pain: does one pain scale fit all?
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
Y1 - 2005/03//
VL - 26
IS - 3
M3 - Article
SP - 125
EP - 130
SN - 01656147
AB - The outcomes of clinical trials are based on the mean responses of large numbers of subjects but fail to address inter-individual differences. The molecular mechanisms that underlie pain vary among individuals over time and among different types of pain to produce wide inter-individual variations in pain perception and response. Gender, ethnicity, temperament and genetic factors also contribute to individual variation in pain sensitivity and responses to analgesics. Pain measurement scales can be used differently across individuals based on the past pain experiences of individuals. We propose that individual responder analyses could be used in clinical trials to better detect analgesic activity across patient groups and within sub-groups, and to identify molecular-genetic mechanisms that contribute to individual variation. [Copyright &y& Elsevier]
AB - Copyright of Trends in Pharmacological Sciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAIN
KW - ANALGESICS
KW - ETHNICITY
KW - TEMPERAMENT
KW - GENETICS
N1 - Accession Number: 16671417; Dionne, Raymond A. 1; Email Address: raymond.dionne@nih.gov Bartoshuk, Linda 2 Mogil, Jeffrey 3 Witter, James 4; Affiliation: 1: NIDCR, National Institutes of Health, 10 Center Drive, Room 1N-103, Bethesda, MD 20892-1197, USA 2: Yale University School of Medicine, Surgery PO Box 208041, New Haven, CT 06520-8041, USA 3: Department of Psychology and Centre for Research on Pain, McGill University, 1205 Dr Penfield Drive, Montreal, QC H3A 1B1, Canada 4: Food and Drug Administration, 9200 Corporate Boulevard, Rockville, MD 20850, USA; Source Info: Mar2005, Vol. 26 Issue 3, p125; Subject Term: PAIN; Subject Term: ANALGESICS; Subject Term: ETHNICITY; Subject Term: TEMPERAMENT; Subject Term: GENETICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.tips.2005.01.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16671417&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-04796-001
AN - 2005-04796-001
AU - Leiderman, Deborah B.
AU - Shoptaw, Steve
AU - Montgomery, Ann
AU - Bloch, Daniel A.
AU - Elkashef, Ahmed
AU - LoCastro, Joseph
AU - Vocci, Frank
T1 - Cocaine Rapid Efficacy Screening Trial (CREST): A paradigm for the controlled evaluation of candidate medications for cocaine dependence.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2005/03//
VL - 100
IS - Suppl1
SP - 1
EP - 11
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Leiderman, Deborah B., Controlled Substance Staff, FDA/CDER, HFD 009 5515 Security Lane no. 1201, Rockville, MD, US, 20852
N1 - Accession Number: 2005-04796-001. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Leiderman, Deborah B.; Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Drug Dependency; Drug Therapy. Minor Descriptor: Screening; Treatment. Classification: Drug & Alcohol Rehabilitation (3383); Research Methods & Experimental Design (2260). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 11. Issue Publication Date: Mar, 2005.
AB - Aim: Development of effective medications for the treatment of cocaine dependence remains a major priority for the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. The Cocaine Rapid Efficacy Screening Trial (CREST) paradigm was developed by the Division of Treatment Research and Development (DT R&D) at NIDA with the goal of enhancing pilot clinical trial validity when systematically assessing a range of medications and drug classes for potential utility in treatment of cocaine dependence. Design: CREST utilizes a randomized, controlled, parallel group, blinded methodology for comparing one or more marketed medications against a standard, pharmaceutical grade placebo. The trial design is comprised of a flexible 2-4-week screening/baseline period followed by randomization to an 8-week treatment period. Measures: Standard measures of outcomes for the CREST included urinary benzoylecgonine (primary metabolite of cocaine), retention, cocaine craving, depression, clinical global impression and HIV-risk behaviors. In order to facilitate comparisons of data from the CREST studies across sites, drug classes and time, standardized procedures, measures and psychosocial counseling were used. Results: A total of 19 medications were evaluated in out-patient treatment research clinics in Boston, Cincinnati, Los Angeles, New York and Philadelphia. Conclusions: Findings supported decisions to move forward three medications (cabergoline, reserpine, tiagabine) using full-scale, adequately powered, randomized placebo-controlled trial designs. Lessons learned from the CREST experience continue to shape cocaine pharmacotherapy trial design and execution. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cocaine dependence
KW - Cocaine Rapid Efficacy Screening Trial
KW - candidate medications
KW - clinical trial
KW - treatment
KW - drug therapy
KW - 2005
KW - Cocaine
KW - Drug Dependency
KW - Drug Therapy
KW - Screening
KW - Treatment
KW - 2005
DO - 10.1111/j.1360-0443.2005.00988.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04796-001&site=ehost-live&scope=site
UR - leidermand@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04796-002
AN - 2005-04796-002
AU - Ciraulo, Domenic A.
AU - Sarid-Segal, Ofra
AU - Knapp, Clifford M.
AU - Ciraulo, Ann Marie
AU - LoCastro, Joseph
AU - Bloch, Daniel A.
AU - Montgomery, Margaret A.
AU - Leiderman, Deborah B.
AU - Elkashef, Ahmed
T1 - Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2005/03//
VL - 100
IS - Suppl1
SP - 12
EP - 22
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Ciraulo, Domenic A., Boston University School of Medicine, Doctors Office Building, Suite 914, 720 Harrison Avenue, Boston, MA, US, 02118
N1 - Accession Number: 2005-04796-002. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Ciraulo, Domenic A.; Division of Psychiatry, Boston University School of Medicine, Boston, MA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Drug Dependency; Paroxetine; Polypharmacy; Venlafaxine. Minor Descriptor: Drug Therapy; Treatment Effectiveness Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Brief Substance Craving Scale; Structured Clinical Interview for the DSM-IV; Clinical Global Impression Observer; Clincial Global Impression Self-Report; Hamilton Anxiety Scale; Hamilton Depression Scale; Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 11. Issue Publication Date: Mar, 2005.
AB - Aims: The two studies presented here were conducted to assess the efficacy of paroxetine, pentoxifylline, riluzole, venlafaxine and pramipexole as medications for the treatment of cocaine dependence. Design: A multi-arm, modified blinded, placebo-controlled design was used. Setting: The studies were conducted at the Boston VA Healthcare System and the Boston University School of Medicine Medication Development Research Unit (MDRU). Participants: Participants met criteria for cocaine dependence during a 2-week screening period. Intervention: Following random assignment to one of the treatment groups, subjects received active medication or placebo for 8 weeks in combination with cognitive behavioral counseling. In the first study the efficacy of the antidepressant paroxetine (20 mg daily), the phosphodiesterase inhibitor pentoxifylline (1200 mg daily) and the glutamate release inhibitor riluzole (100 mg daily) was assessed. The antidepressant venlafaxine (150mg daily) and the dopamine agonist pramipexole (1.5 mg daily) were evaluated in the second study. Measurements: Urine benzoylecgonine (BE) concentrations, self-report of cocaine use and global impression scores served as primary outcome measures. Secondary measures included assessments of cocaine craving and psychiatric functioning. Adverse events were monitored during the treatment period. Findings: None of the active medications produced greater reductions in urine BE concentrations over the treatment period than did placebo. There were trends for BE levels to become reduced in the pentoxifylline group during the first 4 weeks of treatment and for Addiction Severity Index (ASI) drug composite scores to be lower in the pentoxyfylline group at end-point compared to the placebo group. Significant within-group reductions in reported cocaine use and craving were found for all treatment groups, but none of the active medications were superior to placebo on these measures. The accuracy of self-reported cocaine use declined over the study period. Overall, the active medications were well tolerated. Conclusions: This study does not support the use of paroxetine, pentoxifylline, riluzole, venlafaxine or pramipexole for the treatment of cocaine dependence. However, these results need to be interpreted with caution because of the small size and lack of homogeneity of the experimental groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cocaine dependence
KW - paroxetine
KW - pentoxifylline
KW - riluzole
KW - pramipexole
KW - venlafaxine
KW - treatment efficacy
KW - 2005
KW - Cocaine
KW - Drug Dependency
KW - Paroxetine
KW - Polypharmacy
KW - Venlafaxine
KW - Drug Therapy
KW - Treatment Effectiveness Evaluation
KW - 2005
DO - 10.1111/j.1360-0443.2005.00985.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04796-002&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0001-6728-9257
UR - ORCID: 0000-0003-4482-7678
UR - ORCID: 0000-0001-5237-0124
UR - ORCID: 0000-0001-7706-8765
UR - dciraulo@bu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04084-004
AN - 2005-04084-004
AU - Kirby, James B.
AU - Kaneda, Toshiko
T1 - Neighborhood Socioeconomic Disadvantage and Access to Health Care.
JF - Journal of Health and Social Behavior
JO - Journal of Health and Social Behavior
JA - J Health Soc Behav
Y1 - 2005/03//
VL - 46
IS - 1
SP - 15
EP - 31
CY - US
PB - American Sociological Assn
SN - 0022-1465
SN - 2150-6000
AD - Kirby, James B., Agency for Healthcare Research and Quality, 540 Gaither Road, Fifth Floor, Rockville, MD, US, 20850
N1 - Accession Number: 2005-04084-004. PMID: 15869118 Other Journal Title: Journal of Health & Human Behavior. Partial author list: First Author & Affiliation: Kirby, James B.; Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20050613. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual meeting of the Population Association of America, Apr, 2004, Boston, MA, US. Conference Note: An earlier version of the article was presented at the aforementioned conference. Major Descriptor: Disadvantaged; Health Care Utilization; Neighborhoods. Minor Descriptor: Health Care Delivery. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Neighborhood socioeconomic disadvantage scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Mar, 2005.
AB - Most research on access to health care focuses on individual-level determinants such as income and insurance coverage. The role of community-level factors in helping or hindering individuals in obtaining needed care, however, has not received much attention. We address this gap in the literature by examining how neighborhood socioeconomic disadvantage is associated with access to health care. We find that living in disadvantaged neighborhoods reduces the likelihood of having a usual source of care and of obtaining recommended preventive services, while it increases the likelihood of having unmet medical need. These associations are not explained by the supply of health care providers. Furthermore, though controlling for individual-level characteristics reduces the association between neighborhood disadvantage and access to health care, a significant association remains. This suggests that when individuals who are disadvantaged are concentrated into specific areas, disadvantage becomes an 'emergent characteristic' of those areas that predicts the ability of residents to obtain health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - socioeconomic disadvantage
KW - health care access
KW - neighbourhood
KW - community-level factors
KW - 2005
KW - Disadvantaged
KW - Health Care Utilization
KW - Neighborhoods
KW - Health Care Delivery
KW - 2005
DO - 10.1177/002214650504600103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04084-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04796-003
AN - 2005-04796-003
AU - Ciraulo, Domenic A.
AU - Knapp, Clifford
AU - Rotrosen, John
AU - Sarid-Segal, Ofra
AU - Ciraulo, Ann Marie
AU - LoCastro, Joseph
AU - Greenblatt, David J.
AU - Leiderman, Deborah
T1 - Nefazodone treatment of cocaine dependence with comorbid depressive symptoms.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2005/03//
VL - 100
IS - Suppl1
SP - 23
EP - 31
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Ciraulo, Domenic A., Boston University School of Medicine, Doctors Office Building, Suite 914, 720 Harrison Avenue, Boston, MA, US, 02118
N1 - Accession Number: 2005-04796-003. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Ciraulo, Domenic A.; Division of Psychiatry, Boston University School of Medicine, Boston, MA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Comorbidity; Drug Dependency; Major Depression; Nefazodone. Minor Descriptor: Drug Therapy; Norepinephrine; Serotonin Reuptake Inhibitors; Treatment Effectiveness Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Structured Clinical Interview for the DSM-IV; Cocaine Craving Scale; Clinical Global Impression Observer Scale; Risk Assessment Battery; Hamilton Axiety Scale; Hamilton Depression Scale; Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2005.
AB - Aims: In the current study, nefazodone, an antidepressant with dual action on serotonin and norepinephrine reuptake as well as 5-HT2A receptor antagonist effects, was studied in subjects with cocaine dependence and depressive symptoms, to determine its efficacy in reducing cocaine use. Design: An 8-week, double blind, placebo-controlled design was used. Setting: The study was conducted at the Medication Development Research Unit (MDRU) at the VA Boston Healthcare System and the Manhattan Department of Veterans Affairs (DVA) Medical Center. Participants: Subjects (n=69) met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence and had Hamilton Depression Scores of 12 or higher. Intervention: Subjects were assigned randomly to receive nefazodone 200 mg twice daily (n=34) or matching placebo (n=35). All subjects received individual counseling. Measurements: Urinary measurements of benzoylecgonine (BE, three times per week) and self-reports of cocaine use were the primary outcome measures. Secondary outcome measures included assessments of psychiatric functioning, cocaine craving and social functioning. Findings: Median weekly BE declined more rapidly in the nefazodone than in the placebo group. Median urine BE at baseline was, however, significantly greater in nefazodone than in the placebo group. Scores for strength of cocaine craving also decreased more rapidly in the nefazodone group compared to the placebo group. Both groups had equivalent improvement in mood, psychosocial functioning and self-reported cocaine use. Conclusions: These results suggest that nefazodone administration can reduce cocaine craving after it has been administered for several weeks. Although the nefazodone group had a greater rate of decrease in BE levels than the placebo group, the interpretation of this finding is obscured by significant group differences in baseline BE levels. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cocaine dependence
KW - nefazodone treatment
KW - comorbid depressive symptoms
KW - antidepressants
KW - serotonin reuptake inhibitors
KW - norepinephrine reuptake inhibitors
KW - major depression
KW - drug therapy
KW - efficacy
KW - 2005
KW - Cocaine
KW - Comorbidity
KW - Drug Dependency
KW - Major Depression
KW - Nefazodone
KW - Drug Therapy
KW - Norepinephrine
KW - Serotonin Reuptake Inhibitors
KW - Treatment Effectiveness Evaluation
KW - 2005
DO - 10.1111/j.1360-0443.2005.00984.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04796-003&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6728-9257
UR - ORCID: 0000-0001-5237-0124
UR -
UR - ORCID: 0000-0003-4482-7678
UR - ORCID: 0000-0001-7706-8765
UR - dciraulo@bu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06769-004
AN - 2005-06769-004
AU - Power, Kathryn
T1 - Strategies for Transforming Mental Health Care Through Data-Based Decision Making.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2005///Spr 2005
VL - 34
IS - 1
SP - 26
EP - 36
CY - US
PB - ME Sharpe
SN - 0020-7411
AD - Power, Kathryn, CMHS, SAMHSA, 1 Choke Cherry Road, Rockville, MD, US, 20853
N1 - Accession Number: 2005-06769-004. Partial author list: First Author & Affiliation: Power, Kathryn; Center for Mental Health Services, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20050705. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Health Care Delivery; Mental Health; Mental Health Services; Strategies. Minor Descriptor: Evidence Based Practice; Information Systems; Information Technology. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 11. Issue Publication Date: Spr 2005.
AB - The President's New Freedom Commission on Mental Health calls for the transformation of the U.S. mental health-care system. The use of information technology is a cornerstone in the preparation for this mission. Achieving transformation, however, means overcoming existing hindrances to high-quality mental health care for all Americans. Strategies in financing, human resources, rapid integration of evidence-based practices, adoption of performance measures, and expanding the use of information technology are crucial to transforming the behavioral health-care system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - strategies
KW - mental health care system
KW - health care system transformation
KW - decision making
KW - evidence based practices
KW - information technology
KW - health care delivery
KW - 2005
KW - Decision Making
KW - Health Care Delivery
KW - Mental Health
KW - Mental Health Services
KW - Strategies
KW - Evidence Based Practice
KW - Information Systems
KW - Information Technology
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06769-004&site=ehost-live&scope=site
UR - Kathryn.power@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06983-005
AN - 2005-06983-005
AU - Yu, Stella M.
AU - Huang, Zhihuan J.
AU - Schwalberg, Renee H.
AU - Kogan, Michael D.
T1 - Parental Awareness of Health and Community Resources among Immigrant Families.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2005/03//
VL - 9
IS - 1
SP - 27
EP - 34
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Yu, Stella M., Maternal and Child Health Bureau, 5600 Fishers Lane, 18A-55, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06983-005. PMID: 15880972 Partial author list: First Author & Affiliation: Yu, Stella M.; Maternal and Child Health Bureau, Rockville, MD, US. Release Date: 20051024. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Community Services; Health; Immigration; Parental Attitudes. Minor Descriptor: At Risk Populations; Communities; Family. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2005.
AB - Objectives: To examine the association between parental immigrant status and awareness of health and community resources to help address common family problems. Methods: Using the 1999 National Survey of America's Families, a survey of the health, economic, and social characteristics of children and adults, bivariate and multivariate analyses were conducted on 35,938 children to examine the relationship between parents' immigrant status (U.S.-born citizens, naturalized citizens, and noncitizens) and their responses to questions about their awareness of specific health and community resources. Results: Compared to U.S.-born citizens, noncitizens were at the highest risk of not being aware of health and community resources for most outcomes, followed by naturalized citizens. The services of which noncitizens were most likely to be unaware were places to get help for family discord, child care issues, and family violence. Multivariate analyses indicate that parental race/ethnicity, education level, employment status, and child age were other significant independent risk factors. Conclusions: Immigrant parents are at particularly high risk of alienation from systems of health care and support services that are available to low-income and other vulnerable populations in the United States. These findings clearly document disparate awareness among parents of different immigrant status. Community and health resources should reach out to immigrant populations, in linguistically and culturally appropriate ways, to alert them to the availability of their services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental immigrantion status
KW - health resources awareness
KW - community resources awareness
KW - common family problems redressal
KW - US born citizens
KW - naturalized citizens
KW - 2005
KW - Child Care
KW - Community Services
KW - Health
KW - Immigration
KW - Parental Attitudes
KW - At Risk Populations
KW - Communities
KW - Family
KW - 2005
DO - 10.1007/s10995-005-2547-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06983-005&site=ehost-live&scope=site
UR - syu@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06769-009
AN - 2005-06769-009
AU - Manderscheid, Ronald
AU - Carroll, Christopher
T1 - Information Technology and Performance Measures as Transformational Strategies.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2005///Spr 2005
VL - 34
IS - 1
SP - 103
EP - 111
CY - US
PB - ME Sharpe
SN - 0020-7411
AD - Manderscheid, Ronald, CMHS, SAMHSA, 1 Choke Cherry, Rd., Rockville, MD, US, 20853
N1 - Accession Number: 2005-06769-009. Partial author list: First Author & Affiliation: Manderscheid, Ronald; Center for Mental Health Services, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20050705. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Information Systems; Mental Health Services; Performance Tests; Technology. Minor Descriptor: Evidence Based Practice; Information Technology; Strategies. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Spr 2005.
AB - As discussed in other articles in this special issue, the Institute of Medicine's Crossing the Quality Chasm model is ideally suited to promote the transformation of mental health-care delivery systems [1]. The model identifies several key strategies through which transformation takes place, including new approaches to financing, preparing, and training of human resources; the introduction of evidence based practices; and implementation of information technology and performance measurement systems. This article focuses on only the last two of these strategies. Specific topics to be addressed include (a) the role of information technology in transformation, (b) development of a national information technology strategy, (c) development of a common information technology platform for the field, and (d) identification of common performance measures. Special attention is devoted to Decision Support 2000+, a Substance Abuse and Mental Health Services Administration initiative to promote these goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - information technology
KW - performance measures
KW - transformational strategies
KW - mental health care delivery
KW - evidence based practices
KW - 2005
KW - Health Care Delivery
KW - Information Systems
KW - Mental Health Services
KW - Performance Tests
KW - Technology
KW - Evidence Based Practice
KW - Information Technology
KW - Strategies
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06769-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03787-002
AN - 2005-03787-002
AU - Chen, Frederick M.
AU - Fryer, George E. Jr.
AU - Phillips, Robert L. Jr.
AU - Wilson, Elisabeth
AU - Pathman, Donald E.
T1 - Patients' Beliefs About Racism, Preferences for Physician Race, and Satisfaction With Care.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2005/03//Mar-Apr, 2005
VL - 3
IS - 2
SP - 138
EP - 143
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Chen, Frederick M., Department of Family Medicine, University of Washington, Box 354982, Seattle, WA, US, 98195
N1 - Accession Number: 2005-03787-002. PMID: 15798040 Partial author list: First Author & Affiliation: Chen, Frederick M.; Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20050516. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual North American Primary Care Research Group Meeting, 31st, Oct, 2003, Banff, AB, Canada. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Client Attitudes; Client Satisfaction; Health Care Delivery; Racism; Therapist Selection. Minor Descriptor: Health Care Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Mar-Apr, 2005.
AB - Purpose: Few studies have attempted to link patients' beliefs about racism in the health care system with how they use and experience health care. Methods: Using telephone survey data from a national sample of 1,479 whites, 1,189 African Americans, and 983 Latinos, we explored patients' beliefs about racism, their preferences for the race and ethnicity of their physician, and their satisfaction with that physician. A scale was developed to reflect patients' beliefs about racism. Race-stratified analyses assessed associations between patients' beliefs, racial preferences for physicians, choice of physician, and satisfaction with care. Results: Among African Americans, stronger beliefs about racial discrimination in health care were associated with preferring an African American physician (P<.001). Whereas only 22% of African Americans preferred an African American physician, those who preferred a African American physician and had an African American physician were more likely to rate their physician as excellent than did African Americans who preferred a African American physician but had a non-African American physician (57% vs 20%, P<.001). Latinos with stronger beliefs about discrimination in health care were more likely to prefer a Latino physician (P <.001). One third of Latinos preferred a Latino physician. Though not statistically significant, those who preferred and had a Latino physician rated their physician higher than Latinos who preferred a Latino physician but had a non-Latino physician (40% vs 29%). Conclusions: Many African Americans and Latinos perceive racism in the health care system, and those who do are more likely to prefer a physician of their own race or ethnicity. African Americans who have preferences are more often satisfied with their care when their own physicians match their preferences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patients beliefs
KW - racism
KW - patient satisfaction
KW - health care
KW - physicians selection
KW - 2005
KW - Client Attitudes
KW - Client Satisfaction
KW - Health Care Delivery
KW - Racism
KW - Therapist Selection
KW - Health Care Services
KW - 2005
DO - 10.1370/afm.282
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03787-002&site=ehost-live&scope=site
UR - fchen@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00866-001
AN - 2007-00866-001
AU - Rich, Suzanne
T1 - Providing Quality End-of-Life Care.
JF - Journal of Cardiovascular Nursing
JO - Journal of Cardiovascular Nursing
JA - J Cardiovasc Nurs
Y1 - 2005/03//Mar-Apr, 2005
VL - 20
IS - 2
SP - 141
EP - 145
CY - US
PB - Lippincott Williams & Wilkins
SN - 0889-4655
AD - Rich, Suzanne, Product Evaluation Branch I, Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Dr, Rockville, MD, US, 20850
N1 - Accession Number: 2007-00866-001. PMID: 15855863 Partial author list: First Author & Affiliation: Rich, Suzanne; Product Evaluation Branch I, Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, US. Release Date: 20070528. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Nurses; Palliative Care. Minor Descriptor: Death and Dying; Grief; Hospitals; Intervention; Major Depression; Terminally Ill Patients. Classification: Health & Mental Health Services (3370); Professional Psychological & Health Personnel Issues (3400). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Mar-Apr, 2005.
AB - End-of-life care involves not only the care of patients but also the care of those providing care for patients. The routine demands of providing care for patients in end-of-life situations often prevent nurses from working through the grief associated with the death of a patient, resulting in frustration, depression, stress, and eventually, burnout. It is important to recognize that grief and mourning are necessary steps in adjusting to the loss associated with the death of a patient or a loved one. The process of mourning can be likened to the process of healing, with predictable stages or tasks. As nurses providing quality end-of-life care, we can provide an opportunity for a patient's family to begin the process of grieving through appropriate interventions while the patient is still in the hospital or care facility. Recognizing and respecting the appropriateness of individual differences in grief responses creates a means of support for both patients and professionals in healthcare settings. By understanding grief as a predictable, yet individual, response to the loss of a patient or a loved one, we, as nurses, can take care of ourselves while providing quality end-of-life care for our patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality end of life care
KW - health care settings
KW - interventions
KW - patients family
KW - grief
KW - nurses
KW - 2005
KW - Health Care Services
KW - Nurses
KW - Palliative Care
KW - Death and Dying
KW - Grief
KW - Hospitals
KW - Intervention
KW - Major Depression
KW - Terminally Ill Patients
KW - 2005
DO - 10.1097/00005082-200503000-00010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00866-001&site=ehost-live&scope=site
UR - SER@CDRH.FDA.GOV
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-01964-014
AN - 2005-01964-014
AU - Shin, Eun-Joo
AU - Nabeshima, Toshitaka
AU - Suh, Hong-Won
AU - Jhoo, Wang-Kee
AU - Oh, Ki-Wan
AU - Lim, Yong-Kwang
AU - Kim, Dong Sup
AU - Choi, Ki Hwan
AU - Kim, Hyoung-Chun
T1 - Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: Possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression.
JF - Behavioural Brain Research
JO - Behavioural Brain Research
JA - Behav Brain Res
Y1 - 2005/03//
VL - 158
IS - 1
SP - 143
EP - 157
CY - Netherlands
PB - Elsevier Science
SN - 0166-4328
AD - Kim, Hyoung-Chun, Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon, Korea, 200-701
N1 - Accession Number: 2005-01964-014. PMID: 15680202 Partial author list: First Author & Affiliation: Shin, Eun-Joo; Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon, Korea. Release Date: 20050321. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: DNA; Gene Expression; Methamphetamine; Mice; Receptor Binding. Minor Descriptor: Adenosine; Animal Locomotion; Place Conditioning; Side Effects (Drug). Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Mar, 2005.
AB - Current evidence suggests that ginsenosides inhibit methamphetamine (MA)-induced changes in behavior, but the precise mechanisms that underlie this effect are yet to be determined. We examined the role of adenosine receptors in the ginsenoside-induced changes in hyperlocomotion and conditioned place preference (CPP) in mice that occurred in response to administration of MA (2 mg/kg, i.p. × 1 or 2 mg/kg, i.p. × 6). Changes in circling behavior paralleled changes in CPP in the presence of MA. Pre-treatment with ginsenosides (50 or 150 mg/kg, i.p.) attenuated the MA-induced circling behavior and CPP. This attenuation was reversed by the adenosine A2A receptor antagonist l,3,7-trimethyl-8-(3-chrostyryl)xanthine (CSC; 0.5 and 1.0mg/kg) in a dose-dependent manner, but neither the adenosine A₁ receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT; 0.5 and 1.0 mg/kg) nor the A2B receptor antagonist alloxazine (ALX; 1.5 and 3.0 mg/kg) had any such effect. MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides. These reductions were largely prevented by CSC, but not by CPT or ALX. Our results suggest that the stimulation of A2A receptors by ginsenosides attenuates the changes in behavior and the increases in AP-1 DNA binding activity, FRA-IR, and proenkephalin gene expression in mouse striatum that are induced by MA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ginsenosides
KW - methamphetamine
KW - conditioned place preference
KW - locomotor activity
KW - AP-1 transcription factor
KW - proenkephalin
KW - adenosine receptor
KW - striatum
KW - mice
KW - 2005
KW - DNA
KW - Gene Expression
KW - Methamphetamine
KW - Mice
KW - Receptor Binding
KW - Adenosine
KW - Animal Locomotion
KW - Place Conditioning
KW - Side Effects (Drug)
KW - 2005
DO - 10.1016/j.bbr.2004.08.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-01964-014&site=ehost-live&scope=site
UR - kimhc@kangwon.ac.kr
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03684-006
AN - 2005-03684-006
AU - Clark, H. Westley
AU - Power, A. Kathryn
T1 - Women, Co-occurring Disorders, and Violence Study: A case for trauma-informed care.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2005/03//
VL - 28
IS - 2
SP - 145
EP - 146
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Clark, H. Westley, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, U. S. Department of Health and Human Services, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2005-03684-006. PMID: 15780543 Partial author list: First Author & Affiliation: Clark, H. Westley; Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, U. S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20050725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Mental Disorders; Treatment; Violence. Minor Descriptor: Emotional Trauma. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2005.
AB - Because of the concern about interpersonal violence that women in substance abuse and psychiatric treatment report, the Substance Abuse and Mental Health Services Administration (SAMHSA) initiated the Women, Co-occurring Disorders, and Violence Study (WCDVS) to expand knowledge about effective approaches for helping women with histories of trauma, substance abuse, and mental illness. The four articles in this issue describe the methods and the main 6-month outcomes of this program. SAMHSA implemented and managed the WCDVS as a multifaceted project of its three centers: the Center for Substance Abuse Prevention, the Center for Substance Abuse Treatment, and the Center for Mental Health Services. The 6-month WCDVS findings suggest that counseling that integrates and addresses substance abuse, mental health, and trauma issues simultaneously may be a key to improved outcomes among women. The WCDVS findings provide excellent groundwork for further study of integrated treatment for women with co-occurring disorders and histories of interpersonal violence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - co-occurring disorders
KW - interpersonal violence
KW - substance abuse
KW - psychiatric treatment
KW - trauma
KW - program outcomes
KW - 2005
KW - Comorbidity
KW - Drug Abuse
KW - Mental Disorders
KW - Treatment
KW - Violence
KW - Emotional Trauma
KW - 2005
DO - 10.1016/j.jsat.2005.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03684-006&site=ehost-live&scope=site
UR - westley.clark@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03545-008
AN - 2005-03545-008
AU - Fillenbaum, Gerda G.
AU - McCurry, Susan M.
AU - Kuchibhatla, Maragatha
AU - Masaki, Kamal H.
AU - Borenstein, Amy R.
AU - Foley, Daniel J.
AU - Heyman, Albert
AU - Larson, Eric B.
AU - White, Lon
T1 - Performance on the CERAD neuropsychology battery of two samples of Japanese-American elders: Norms for persons with and without dementia.
JF - Journal of the International Neuropsychological Society
JO - Journal of the International Neuropsychological Society
JA - J Int Neuropsychol Soc
Y1 - 2005/03//
VL - 11
IS - 2
SP - 192
EP - 201
CY - United Kingdom
PB - Cambridge University Press
SN - 1355-6177
SN - 1469-7661
AD - Fillenbaum, Gerda G., Center for the Study of Aging and Human Development, Duke University Medical Center, Box 3003, Durham, NC, US, 27710
N1 - Accession Number: 2005-03545-008. PMID: 15966108 Partial author list: First Author & Affiliation: Fillenbaum, Gerda G.; Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, US. Release Date: 20050425. Correction Date: 20140519. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Assessment; Dementia; Japanese Cultural Groups; Minority Groups; Neuropsychological Assessment. Minor Descriptor: Statistical Norms. Classification: Neuropsychological Assessment (2225); Neurological Disorders & Brain Damage (3297). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Informant Questionnaire for Cognitive Decline in the Elderly; Consortium to Establish a Registry for Alzheimers Disease Neuropsychology Battery; Shipley Vocabulary Scale; Wechsler Adult Intelligence Scale-Revised; Trails A and B Modified; Purdue Pegboard Test; Clinical Dementia Rating DOI: 10.1037/t28287-000; Cognitive Abilities Screening Instrument DOI: 10.1037/t28521-000; Wechsler Memory Scale--Revised. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2005.
AB - Norms for cognitive measures used to assess dementia are scant for minority groups, in particular for older Japanese Americans. Using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychology Battery, we compared the baseline performance of demented and nondemented Japanese Americans. Participants came from two harmonized epidemiological studies of dementia which were examined separately: the Kame Project, Seattle (350 men and women; 201 nondemented), age 65 and older; Honolulu-Asia Aging Study (HAAS), Hawaii (418 men; 120 nondemented), age 71 and older. The measures examined were Verbal Fluency; abbreviated Boston Naming; constructional praxis; and Word List Learning, Recall, and Recognition. Within each study, the CERAD measures distinguished between nondemented participants and those with mild cognitive impairment. Among persons with dementia, average level of performance decreased as severity of dementia increased. Determinants of score (age, education, language of administration, stage of dementia) varied between the two studies. Among Japanese Americans, the CERAD Neuropsychology Battery distinguished nondemented persons from those with dementia, but was less consistent in distinguishing levels of severity of dementia. This battery is useful for comparative epidemiological studies of dementia in minority populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognitive measures
KW - minority populations
KW - dementia
KW - neuropsychology battery
KW - norms
KW - Japanese American elders
KW - 2005
KW - Cognitive Assessment
KW - Dementia
KW - Japanese Cultural Groups
KW - Minority Groups
KW - Neuropsychological Assessment
KW - Statistical Norms
KW - 2005
DO - 10.1017/S1355617705050198
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03545-008&site=ehost-live&scope=site
UR - ggf@geri.duke.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03173-010
AN - 2005-03173-010
AU - Clark, H. Westley
AU - Bizzell, Anton C.
T1 - A Federal Perspective on the Abuse of Prescription Stimulants.
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 2005/03//
VL - 35
IS - 3
SP - 261
EP - 263
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
AD - Bizzell, Anton C., Center for Substance Abuse Treatment, 1 Choke Cherry Road, Room 2-1067, Rockville, MD, US, 20857
N1 - Accession Number: 2005-03173-010. Partial author list: First Author & Affiliation: Clark, H. Westley; Center for Substance Abuse Treatment, Rockville, MD, US. Release Date: 20050404. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: CNS Stimulating Drugs; Drug Abuse; Drug Laws; Drug Therapy; Prescription Drugs. Classification: Substance Abuse & Addiction (3233); Forensic Psychology & Legal Issues (4200). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Mar, 2005.
AB - Prescription medications are misused and abused by a significant number of young people and adults. The Substance Abuse and Mental Health Services Administration (SAMHSA) 2003 National Survey on Drug Use and Health (NSDUH) surveyed people 12 or older to report their illicit drug use, including their nonmedical use of prescription drugs (ie, pain relievers, tranquilizers, stimulants, sedatives). Nonmedical use is defined as the use of prescription-type drugs not prescribed for the respondent by a physician or used for the experience or feeling they caused. Nonmedical use does not include over-the-counter drugs. It also reported that 20.8 million Americans 12 or older had used prescription-type stimulants nonmedically at least once in their lifetime. The fact that a small portion of prescription medications are prescribed inappropriately by physicians and misused or abused by patients and others raises an important policy dilemma. How can we make such medications readily available for therapeutic use while limiting access for nontherapeutic misuse or abuse? SAMHSA recommendation to the broader problem of prescription drug misuse and abuse are: Uniform Definitions Should Be Established, More Useful Data Are Needed, Health Professionals Need Better Training, Patients and the Public Need Accurate Information, and Public Policies Must Respond to Multiple Needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prescription medication
KW - drug misuse
KW - drug abuse
KW - stimulants
KW - 2005
KW - CNS Stimulating Drugs
KW - Drug Abuse
KW - Drug Laws
KW - Drug Therapy
KW - Prescription Drugs
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03173-010&site=ehost-live&scope=site
UR - anton.bizzell@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03372-001
AN - 2005-03372-001
AU - Hsiao, H.
AU - Whitestone, J.
AU - Bradtmiller, B.
AU - Whisler, R.
AU - Zwiener, J.
AU - Lafferty, C.
AU - Kau, T. -Y.
AU - Gross, M.
T1 - Anthropometric criteria for the design of tractor cabs and protection frames.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2005/03//
VL - 48
IS - 4
SP - 323
EP - 352
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Hsiao, H.
N1 - Accession Number: 2005-03372-001. Partial author list: First Author & Affiliation: Hsiao, H.; National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20050425. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Agricultural Workers; Human Machine Systems Design; Motor Vehicles; Safety. Classification: Lifespace & Institutional Design (4030). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 30. Issue Publication Date: Mar, 2005.
AB - Improved human-tractor interface designs, such as well-accommodated operator enclosures (i.e. cabs and protection frames) can enhance operator productivity, comfort and safety. This study investigated farm-worker anthropometry and determined the critical anthropometric measures and 3- D feature envelopes of body landmarks for the design of tractor operator enclosures. One hundred agriculture workers participated in the study. Their body size and shape information was registered, using a 3-D full-body laser scanner. Knee height (sitting) and another eight parameters were found to affect the cab-enclosure accommodation rating and multiple anthropometric dimensions interactively affected the steering wheel and gear-handle impediment. A principal component analysis has identified 15 representative human body models for digitally assessing tractor-cab accommodation. A set of centroid coordinates of 34 body landmarks and the 95% confidence semiaxis- length for each landmark location were developed to guide tractor designers in their placement of tractor control components in order to best accommodate the user population. Finally, the vertical clearance (90 cm) for agriculture tractor enclosure in the current SAE International J2194 standard appeared to be too short as compared to the 99th percentile sitting height of male farm workers in this study (100.6 cm) and in the 1994 National Health and Nutrition Examination Survey III database (99.9 cm) and of the male civilian population in the 2002 Civilian American and European Surface Anthropometric Resource database (100.4 cm). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - anthropometric criteria
KW - tractor cabs
KW - human tractor interface designs
KW - operator productivity
KW - safety
KW - farm workers
KW - 2005
KW - Agricultural Workers
KW - Human Machine Systems Design
KW - Motor Vehicles
KW - Safety
KW - 2005
DO - 10.1080/00140130512331332891
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03372-001&site=ehost-live&scope=site
UR - hhsiao@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-02429-035
AN - 2005-02429-035
AU - Johnsen, Matthew
AU - Geller, Jeffrey L.
ED - Geller, Jeffrey L.
T1 - Review of Tributes: Personal Reflections on a Century of Social Research.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/03//
VL - 56
IS - 3
SP - 366
EP - 367
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2005-02429-035. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Johnsen, Matthew; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20050404. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Experimentation; History; Social Sciences. Minor Descriptor: Experimenters; History of Psychology; Sociology. Classification: History & Systems (2140). Population: Human (10). Reviewed Item: Horowitz, Irving Louis. Tributes: Personal Reflections on a Century of Social Research=New Brunswick, New Jersey, Transaction Publishers, 2004, 344 pages, $35.95; 2004. References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2005.
AB - Reviews the book 'Tributes: Personal Reflections on a Century of Social Research' by Irving Louis Horowitz (see record [rid]2003-88179-000[/rid]). My dilemma in reviewing this book is that the book's entries are uneven and quite personal. Some subjects were colleagues, and their tributes were written as memorials. Other contributions are about intellectual contestants, the contribution having served a different purpose, such as a presentation in a debate. As such, in some places the tone is loving and uncritical; in others, it is highly critical and provocative. Those who are interested in developing a deeper understanding of ideological contests during an enormously productive time of social theorizing may find that this book fills some gaps, providing interesting chapters about some individuals who are not well recognized today. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - personal reflections
KW - social science
KW - social research
KW - tributes
KW - 2005
KW - Experimentation
KW - History
KW - Social Sciences
KW - Experimenters
KW - History of Psychology
KW - Sociology
KW - 2005
U2 - Horowitz, Irving Louis. (2004); Tributes: Personal Reflections on a Century of Social Research; New Brunswick, New Jersey, Transaction Publishers, 2004, 344 pages, $35.95
DO - 10.1176/appi.ps.56.3.366-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-02429-035&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Elkashef, Ahmed
AU - Holmes, Tyson H.
AU - Bloch, Daniel A.
AU - Shoptaw, Steve
AU - Kampman, Kyle
AU - Reid, Malcolm S.
AU - Somoza, Eugene
AU - Ciraulo, Domenic
AU - Rotrosen, John
AU - Leiderman, Deborah
AU - Montgomery, Ann
AU - Vocci, Frank
T1 - Retrospective analyses of pooled data from CREST I and CREST II trials for treatment of cocaine dependence.
JO - Addiction
JF - Addiction
Y1 - 2005/03/02/Mar2005 Supplement 1
VL - 100
M3 - Article
SP - 91
EP - 101
PB - Wiley-Blackwell
SN - 09652140
AB - To analyze pooled data from the Cocaine Rapid Evaluation Screening Trial (CREST). Pooling data from these small pilot trials into four major drug classes permitted data exploration for treatment and covariate effects with increased sample size.Small pilot trials were conducted to screen fifteen medications as prospective treatments for cocaine dependence. Studies included a flexible 2-week to 4-week screening/baseline period followed by an 8-week randomized treatment condition. Participants were randomized equally to one of up to three active medications or placebo.Five Medications Development Research Units at the five academic centers of University of Cincinnati, New York University, University of Pennsylvania, University of California Los Angeles and Boston University.The pooled data set consisted of 357 total subjects. Standardized inclusion and exclusion criteria were employed in subject selection to enhance consistency of cocaine-dependent study participants across all sites (see reports on individual trials in this supplement for details). All participants provided at least two urine samples that were positive for cocaine metabolite during a two-week period prior to being randomized.All subjects in these trials, those randomized to placebo and active medications, received active treatment in the form of evidence-based cognitive behavioral therapy.Quantitative urine benzoylecgonine (BE), self-report of cocaine use, and total Brief Substance Craving Scale (BSCS) scores were compared between each class of medication and its matched-placebo group.Regression analysis of pooled data did not identify any statistically significant differences between treatment and matched-placebo for any of the four classes. Exploration of the effects of baseline covariates indicated that gender and African American status were associated significantly with outcome. Female gender was consistently associated with poorer outcomes for medication and placebo groups, while the direction of association between African American status and outcome differed by treatment groups. Retention was also examined: dropout rates may have been somewhat higher for placebo than treatment groups during the early active-treatment period. Classification trees were used to identify characteristics of subjects who were abstinent for at least two weeks during the eight-week trial; only 4.0% of females while 17.9% of males achieved this criterion.Results presented here may prove useful for planning future clinical trials for therapies targeting cocaine dependence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - DRUG abuse
KW - COCAINE
KW - PLACEBOS (Medicine)
KW - BEHAVIOR therapy
KW - NARCOTICS
KW - Cocaine
KW - pharmacotherapy
KW - statistics.
N1 - Accession Number: 16224285; Elkashef, Ahmed 1 Holmes, Tyson H. 2; Email Address: tholmes@stanford.edu Bloch, Daniel A. 2 Shoptaw, Steve 3,4 Kampman, Kyle 5 Reid, Malcolm S. 6 Somoza, Eugene 7,8 Ciraulo, Domenic 9 Rotrosen, John 6 Leiderman, Deborah 1,10 Montgomery, Ann Vocci, Frank 1; Affiliation: 1: Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. 2: Stanford University School of Medicine, Department of Health Research and Policy, Division of Biostatistics, Stanford, CA, USA. 3: University of California, Los Angeles, Integrated Substance Abuse Programs, Los Angeles, CA, USA. 4: Friends Research Institute, Inc., Los Angeles, CA, USA. 5: The Philadelphia Veterans Affairs Medical Center Philadelphia, PA, USA. 6: New York University School of Medicine and VA New York Harbor Healthcare System, Department of Psychiatry, New York, NY, USA. 7: Cincinnati VA Medical Center Cincinnati, OH, USA. 8: Cincinnati Addiction Research Center (CinARC), University of Cincinnati College of Medicine, Cincinnati, OH, USA. 9: Division of Psychiatry, Boston University School of Medicine and VA Boston Healthcare System Medication Development Research Unit (MDRU), Boston, MA, USA. 10: Center for Drug Evaluation and Research, Food and Drug Administration, Rodville, MD, USA.; Source Info: Mar2005 Supplement 1, Vol. 100, p91; Subject Term: CLINICAL trials; Subject Term: DRUG abuse; Subject Term: COCAINE; Subject Term: PLACEBOS (Medicine); Subject Term: BEHAVIOR therapy; Subject Term: NARCOTICS; Author-Supplied Keyword: Cocaine; Author-Supplied Keyword: pharmacotherapy; Author-Supplied Keyword: statistics.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1360-0443.2005.00986.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16224285&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106611488
T1 - Cocaine Rapid Efficacy Screening Trial (CREST): a paradigm for the controlled evaluation of candidate medications for cocaine dependence.
AU - Leiderman DB
AU - Shoptaw S
AU - Montgomery A
AU - Bloch DA
AU - Elkashef A
AU - LoCastro J
AU - Vocci F
Y1 - 2005/03/02/Mar2005 Supplement 1
N1 - Accession Number: 106611488. Language: English. Entry Date: 20050422. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Supplement Title: Mar2005 Supplement 1. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Clinical Global Impression Scores (Tracy et al); Risk Assessment Battery (RAB) (Navaline et al); Addiction Severity Index (ASI) (McLellan et al); Brief Substance Craving Scale (BSCS); Hamilton Rating Scale for Depression (HRSD); Hamilton Anxiety Rating Scale; Structured Clinical Inventory for the DSM-IV (SCID) (Spitzer et al). Grant Information: Funded by the National Institute on Drug Abuse (NIDA) through Interagency Agreement Y01 DA 50038-05. NLM UID: 9304118.
KW - Cocaine
KW - Substance Dependence -- Drug Therapy
KW - Clinical Trials
KW - Counseling
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Hamilton Rating Scale for Depression
KW - Interview Guides
KW - Male
KW - Mann-Whitney U Test
KW - Outpatients
KW - Post Hoc Analysis
KW - Random Assignment
KW - Research Instruments
KW - Reserpine -- Therapeutic Use
KW - Scales
KW - Self Report
KW - Summated Rating Scaling
KW - T-Tests
KW - Treatment Outcomes
KW - Two-Tailed Test
KW - Type I Error
KW - United States
KW - Human
SP - 1
EP - 11
JO - Addiction
JF - Addiction
JA - ADDICTION
VL - 100
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Aim Development of effective medications for the treatment of cocaine dependence remains a major priority for the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. The Cocaine Rapid Efficacy Screening Trial (CREST) paradigm was developed by the Division of Treatment Research and Development (DT R&D) at NIDA with the goal of enhancing pilot clinical trial validity when systematically assessing a range of medications and drug classes for potential utility in treatment of cocaine dependence.Design CREST utilizes a randomized, controlled, parallel group, blinded methodology for comparing one or more marketed medications against a standard, pharmaceutical grade placebo. The trial design is comprised of a flexible 2 4-week screening/baseline period followed by randomization to an 8-week treatment period.Measures Standard measures of outcomes for the CREST included urinary benzoylecgonine (primary metabolite of cocaine), retention, cocaine craving, depression, clinical global impression and HIV-risk behaviors. In order to facilitate comparisons of data from the CREST studies across sites, drug classes and time, standardized procedures, measures and psychosocial counseling were used.Results A total of 19 medications were evaluated in out-patient treatment research clinics in Boston, Cincinnati, Los Angeles, New York and Philadelphia.Conclusions Findings supported decisions to move forward three medications (cabergoline, reserpine, tiagabine) using full-scale, adequately powered, randomized placebo-controlled trial designs. Lessons learned from the CREST experience continue to shape cocaine pharmacotherapy trial design and execution.
SN - 0965-2140
AD - Director, Food Substance Staff, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20852; leidermand@cder.fda.gov
U2 - PMID: 15773068.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106611488&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hughes, Ronda G.
AU - Ortiz, Eduardo
T1 - Medication Errors.
JO - American Journal of Nursing
JF - American Journal of Nursing
Y1 - 2005/03/02/Mar2005 Supplement
VL - 105
IS - 3
M3 - Article
SP - 14
EP - 24
SN - 0002936X
AB - The article focuses on the cause of medication errors and suggestion to prevent them. It provides an overview of what is known about errors in medication administration, barriers to implementing safer practices and current potential mechanisma to improve medication administration. Some medication errors change a patient's outcome, but the change does not result in any harm. Other medication errors have potential to cause harm. Serious medication errors that are not intercepted, will actually harm the patient. One of the every three adverse drug events precipitated by a medication errors occurs when a nurse administers medication to a patient.
KW - MEDICATION errors
KW - ADMINISTRATION of drugs
KW - DOSAGE of drugs
KW - MEDICAL errors
KW - PATIENTS
KW - NURSES
N1 - Accession Number: 16348373; Hughes, Ronda G. 1,2; Email Address: rhughes@ahrq.gov Ortiz, Eduardo 3; Affiliation: 1: Senior Health Scientist Administrator and senior Advisor on End-of-Life Care, Center for Primary Care, prevention. 2: Clinical Partnerships of the Agency for Healthcare Research and Quality, Rockville, MD. 3: Associate Chief of Staff, Director of Clinical Informatics and Faculty Physician , VA Medical Center, Washington, DC.; Source Info: Mar2005 Supplement, Vol. 105 Issue 3, p14; Subject Term: MEDICATION errors; Subject Term: ADMINISTRATION of drugs; Subject Term: DOSAGE of drugs; Subject Term: MEDICAL errors; Subject Term: PATIENTS; Subject Term: NURSES; Number of Pages: 11p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16348373&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106639861
T1 - Medication errors: why they happen, and how they can be prevented.
AU - Hughes RG
AU - Ortiz E
Y1 - 2005/03/02/Mar2005 Supplement
N1 - Accession Number: 106639861. Language: English. Entry Date: 20050603. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions; review; tables/charts. Supplement Title: Mar2005 Supplement. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Drug Administration
KW - Medication Errors
KW - Medication Systems
KW - Clinical Information Systems
KW - Education, Continuing (Credit)
KW - Medication Compliance
KW - Medication Errors -- Epidemiology -- United States
KW - Medication Errors -- Prevention and Control
KW - Organizational Culture
KW - Prescriptions, Drug
KW - United States
SP - 14
EP - 51
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 105
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Senior Advisor on End-of-Life Care, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD; rhughes@ahrq.gov
U2 - PMID: 15802994.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106639861&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zheng, Jenny H.
T1 - TOPIC IV: HORMONAL INFLUENCE ON TREATMENT AND THE EFFECT OF TREATMENTS ON CONTRACEPTIVE METHODS, CONTINUED: Data from the United States Food and Drug Administration.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/03/02/3/1/2005 Supplement 1
VL - 38
M3 - Article
SP - S24
EP - 26
SN - 15254135
AB - Reports on the use of oral contraceptives (OC) by HIV-infected women to prevent pregnancy in the U.S. Need for better evaluation of the exposure-response relationships of OCs in order to understand the clinical significance of the OC plasma concentration changes; Effect of drug-drug interactions between OC and other drugs on the safety of OCs and highly active antiretroviral therapy; Inclusion of drug-drug interaction information in drug product prescription information.
KW - ORAL contraceptives
KW - HIV-positive persons
KW - BIRTH control
KW - PREGNANCY
KW - ANTIRETROVIRAL agents
KW - DRUGS -- Effectiveness
KW - UNITED States
N1 - Accession Number: 16994141; Zheng, Jenny H. 1; Affiliation: 1: US Food and Drug Administration, DHHS; Source Info: 3/1/2005 Supplement 1, Vol. 38, pS24; Subject Term: ORAL contraceptives; Subject Term: HIV-positive persons; Subject Term: BIRTH control; Subject Term: PREGNANCY; Subject Term: ANTIRETROVIRAL agents; Subject Term: DRUGS -- Effectiveness; Subject Term: UNITED States; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16994141&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Daniel
AU - Mackay, Trent
AU - Utian, Wulf
AU - Grinspoon, Steven
T1 - TOPIC VII: WHAT IS THE ROLE OF HORMONAL MENOPAUSAL THERAPY IN HIV-INFECTED AND AT-RISK WOMEN?: Effect of Estrogen Receptors (Reports from the FDA, NIH, ACOG, and NAMS) and the Role of Testosterone and Bone Density.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/03/02/3/1/2005 Supplement 1
VL - 38
M3 - Article
SP - S45
EP - S45
SN - 15254135
AB - Explores the regulation issued on the labeling of estrogen receptors by the U.S. Food and Drug Administration. Revision of the labels for Prempro, Premphase and Premarin for patients and healthcare providers to reflect the findings of the Women's Health Initiative on increased risk from the products; Promotion of alternative therapies for vaginal and vulvar atrophy; Advice given to women regarding the use of hormonal therapy.
KW - PHARMACEUTICAL policy
KW - HORMONE therapy
KW - ESTROGEN receptors
KW - WOMEN -- Health
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 16994153; Davis, Daniel 1 Mackay, Trent 1 Utian, Wulf 1 Grinspoon, Steven 1; Affiliation: 1: US Food and Drug Administration, DHHS, USA; Source Info: 3/1/2005 Supplement 1, Vol. 38, pS45; Subject Term: PHARMACEUTICAL policy; Subject Term: HORMONE therapy; Subject Term: ESTROGEN receptors; Subject Term: WOMEN -- Health; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 3/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106634287
T1 - Medication errors: why they happen, and how they can be prevented.
AU - Hughes RG
AU - Ortiz E
Y1 - 2005/03/02/2005 Supplement
N1 - Accession Number: 106634287. Language: English. Entry Date: 20050520. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; tables/charts. Supplement Title: 2005 Supplement. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101124170.
KW - Medication Errors -- Etiology
KW - Medication Errors -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Health Information Systems
KW - Organizational Culture
SP - 14
EP - 51
JO - Journal of Infusion Nursing
JF - Journal of Infusion Nursing
JA - J INFUSION NURS
VL - 28
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1533-1458
AD - Senior Health Scientist Administrator, Center for Primary Care, Prevention, and Clinical Partnerships of the Agency for Healthcare Research and Quality, Rockville, MD; rhughes@ahrq.gov
U2 - PMID: 15965368.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106634287&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106472572
T1 - Assessing patient safety in the United States: challenges and opportunities.
AU - Zhan C
AU - Kelley E
AU - Yang HP
AU - Keyes M
AU - Battles J
AU - Borotkanics RJ
AU - Stryer D
Y1 - 2005/03/02/2005 Mar Supplement
N1 - Accession Number: 106472572. Language: English. Entry Date: 20050624. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2005 Mar Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Patient Safety
KW - Performance Measurement Systems -- Evaluation
KW - Electronic Health Records
KW - Conceptual Framework
KW - Mandatory Reporting
KW - United States Agency for Healthcare Research and Quality
KW - United States Centers for Medicare and Medicaid Services
KW - Human
SP - I
EP - 42
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: In 1999, the US Congress mandated the Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services (DHHS), to report annually to the nation about healthcare quality. One chapter in the National Healthcare Quality Report (NHQR) is focused on patient safety. OBJECTIVES: The objectives of this study were to describe the challenges in reporting the national status on patient safety for the first NHQR and discuss emerging opportunities to improve the comprehensiveness and reliability of future reporting. RESEARCH DESIGN: This study is a selective review of definitions, frameworks, data sources, measures, and emerging developments for assessing patient safety in the United States. RESULTS: Available data and measures for patient safety assessment in the nation are inadequate, especially for comparing regions and subpopulations and for trend analysis. However, many opportunities are emerging from the recently increased investments in patient safety research and many ongoing safety improvement efforts in the private sector and at the federal, state, and local government levels. CONCLUSION: There are many challenges in assessing national performance on patient safety today. Ongoing developments on multiple fronts will provide data and measures for more accurate and more comprehensive assessments of patient safety for future NHQRs.
SN - 0025-7079
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; czhan@ahrq.gov
U2 - PMID: 15746590.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106472572&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106472566
T1 - Challenges in measuring nursing home and home health quality: lessons from the First National Healthcare Quality Report.
AU - Sangl J
AU - Saliba D
AU - Gifford DR
AU - Hittle DF
Y1 - 2005/03/02/2005 Mar Supplement
N1 - Accession Number: 106472566. Language: English. Entry Date: 20050624. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2005 Mar Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: AHRQ intramural funding; VA HSR&D Career Development award #RCD 01-006; CMS Contract No. 500-00-0026. NLM UID: 0230027.
KW - Clinical Indicators
KW - Home Health Care -- Evaluation
KW - Long Term Care -- Evaluation
KW - Nursing Homes -- Evaluation
KW - Performance Measurement Systems -- Evaluation
KW - Descriptive Statistics
KW - Funding Source
KW - Interrater Reliability
KW - Intraclass Correlation Coefficient
KW - Kappa Statistic
KW - Minimum Data Set -- Evaluation
KW - Outcome Assessment Information Set -- Evaluation
KW - Reliability and Validity
KW - Risk Assessment
KW - Human
SP - I
EP - 24
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: The availability of patient assessment data collected by all Medicare- and Medicaid-certified nursing homes (NHs) (the Minimum Data Set [MDS]) and home health agencies (HHAs) (the Outcome and Assessment Information Set [OASIS]) provides an opportunity to measure quality of care in these settings. OBJECTIVE: The objective of this study was to examine methodologic issues encountered as these datasets are used to report the nation's health care in the National Healthcare Quality Report (NHQR) at national and state levels. FINDINGS: Although the reliability of most data elements from MDS and OASIS are considered acceptable in research studies, mixed evidence exists for the reliability and validity of the quality measures themselves. Detection bias can affect the quality measures, particularly for pain and pressure ulcers. Although risk adjustment is used for all measures, effectiveness varies among measures and methods. Additional quality measures such as patient satisfaction, quality of life, and structural measures would be desirable but will require additional data collection efforts. Although the NH measures represent most NH residents, the HHA measures only apply to Medicare and Medicaid patients served by Medicare-certified agencies. Finally, the absence of clinical benchmarks limits the interpretation of the NHQR HHA and NH measures. CONCLUSIONS: Further developmental work is needed to address many of these issues to improve the usefulness of these quality measures in future NHQR reports.
SN - 0025-7079
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD; jsangl@ahrq.gov
U2 - PMID: 15746587.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106472566&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106472581
T1 - Children's health care in the first National Healthcare Quality Report and National Healthcare Disparities Report.
AU - Dougherty D
AU - Meikle SF
AU - Owens P
AU - Kelley E
AU - Moy E
Y1 - 2005/03/02/2005 Mar Supplement
N1 - Accession Number: 106472581. Language: English. Entry Date: 20050624. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: 2005 Mar Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Clinical Indicators
KW - Pediatric Care -- Evaluation
KW - Performance Measurement Systems -- Evaluation
KW - Quality of Health Care -- Evaluation
KW - Adolescence
KW - Antibiotics -- Administration and Dosage
KW - Asthma -- Epidemiology
KW - Birth Weight
KW - Blacks
KW - Child
KW - Child, Preschool
KW - Health Services Accessibility
KW - Hispanics
KW - Immunization
KW - Infant
KW - Infant Mortality
KW - Infant, Newborn
KW - Race Factors
KW - Whites
KW - Human
SP - I
EP - 58
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: The first National Healthcare Quality Report (NHQR) and National Healthcare Disparities Report (NHDR) are landmark events for children's health care quality and are expected to stimulate local measurement, benchmarking, and quality improvement efforts. METHOD: The authors select findings from the NHQR and NHDR, focusing on topics reflecting a range of health care and health care settings affecting children. They highlight disparities by race/ethnicity, socioeconomic status, and insurance source. They critique the first NHQR and NHDR from a child health perspective. SELECT NHQR/DR FINDINGS: Quality-of-care issues in the effectiveness domain were identified for black infant mortality, low and very low birth weight rates, antibiotic use for the common cold, and childhood hospitalizations for asthma. Immunization rates have improved. Patient centeredness and timeliness results vary by race, ethnicity and income. The NHDR found that Hispanic and low-income children are most likely to be uninsured for part of the year. Groups of children most likely to have public coverage are American Indian/Alaska native, black, and Hispanic. CRITIQUE OF REPORTS: The structure and criteria used for the first reports limit their usefulness from a child health perspective. A basic problem is that the conceptualizations of health and health care that are driving national initiatives on quality are based largely on an adult chronic care model focused on conditions with high expenditures as treated in the mainstream health care delivery system. CONCLUSION: NHQR and NHDR provide essential information on children's health care quality. Future reports can be improved by including child-relevant perspectives in priority-setting and data-gathering efforts.
SN - 0025-7079
AD - Senior Advisor, Child Health and Quality Improvement, Agency for Healthcare Research and Quality, John M. Eisenberg Building, 540 Gaither Road, Rockville, MD 20850; ddougher@ahrq.gov
U2 - PMID: 15746592.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106472581&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106472588
T1 - NHQR/NHDR measures for women of reproductive age.
AU - Sharp BAC
AU - Meikle SF
AU - James MD
AU - Steiner C
AU - Remus D
Y1 - 2005/03/02/2005 Mar Supplement
N1 - Accession Number: 106472588. Language: English. Entry Date: 20050624. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2005 Mar Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Clinical Indicators
KW - Performance Measurement Systems -- Evaluation
KW - Quality of Health Care -- Evaluation
KW - Women's Health
KW - Acquired Immunodeficiency Syndrome -- Drug Therapy
KW - Acquired Immunodeficiency Syndrome -- Mortality
KW - Acquired Immunodeficiency Syndrome -- Prevention and Control
KW - Adult
KW - Breast Neoplasms -- Epidemiology
KW - Breast Neoplasms -- Mortality
KW - Cervix Neoplasms -- Epidemiology
KW - Cervix Neoplasms -- Mortality
KW - Depression -- Drug Therapy
KW - Female
KW - Maternal Mortality
KW - Patient Centered Care
KW - Pregnancy
KW - Prenatal Care -- Evaluation
KW - Suicide -- Epidemiology
KW - Time
SP - I
EP - 64
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: This article addresses measures of importance to women of reproductive age in the first National Healthcare Quality Report (NHQR) and National Healthcare Disparities Report (NHDR). METHODS: The authors review each of the 4 components of quality of care: effectiveness, safety, timeliness, and patient centeredness. The effectiveness component topics with relevance to women of childbearing age include breast cancer, cervical cancer, HIV, AIDS, mental health, and maternity care. The safety component includes 3 relevant measures of obstetric trauma. The quality aspects of timeliness of care and patient centeredness will be discussed in terms of women, although the NHQR and NHDR did not include them as a separate topic because the data were so limited regarding women. FINDINGS: There is a foundation of knowledge about many aspects of quality health care for women of reproductive age. However, gaps are evident in some measures, usually due to insufficient data. CONCLUSION: Further development of the measure set would benefit from additional process and outcome variables that can link screening, diagnosis, and treatment with health outcomes. Such linkages will expand our knowledge and capability to improve health outcomes for women of reproductive age.
SN - 0025-7079
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; BCSHARP@AHRQ.GOV
U2 - PMID: 15746593.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106472588&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106472591
T1 - Variation in quality of men's health care by race/ethnicity and social class.
AU - Felix-Aaron K
AU - Moy E
AU - Kang M
AU - Patel M
AU - Chesley FD
AU - Clancy C
Y1 - 2005/03/02/2005 Mar Supplement
N1 - Accession Number: 106472591. Language: English. Entry Date: 20050624. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2005 Mar Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 0230027.
KW - Men's Health
KW - Quality of Health Care -- Evaluation
KW - Race Factors
KW - Socioeconomic Factors
KW - Asians
KW - Blacks
KW - Conceptual Framework
KW - Descriptive Statistics
KW - Funding Source
KW - Hispanics
KW - Kidney Failure, Chronic -- Therapy
KW - Male
KW - P-Value
KW - Patient Centered Care
KW - Postoperative Complications -- Epidemiology
KW - Relative Risk
KW - Substance Abuse
KW - Whites
KW - Human
SP - I
EP - 72
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Until recently, minority and poor men have been characterized as 'an invisible population,' overlooked by public and private efforts to improve the health status of women, children, and the elderly. OBJECTIVE: This study compares the health care experiences of racial and ethnic minority men with that of white men, and low socioeconomic status with those of higher status. MEASURES/SUBJECTS: Quality-of-care measures in multiple clinical domains are evaluated. The authors use data from several databases, including the National Health Interview Survey, Medical Expenditure Panel Survey, and Health Care Cost and Utilization Project State Inpatient Database. The relative difference between each racial/ethnic and socioeconomic group and a fixed reference group is used to assess differences in use of services. Statistical significance is assessed using z tests. RESULTS: Hispanic men were much less likely to receive colorectal cancer screening (relative risk [RR] range, 0.61-0.69), cardiovascular risk factor screening and management (RR, 0.84-0.88), and vaccinations (RR, 0.47-0.94). Black and Asian men were significantly less likely to have received selected preventive services (adult immunization and colorectal cancer screening). The differences in end-stage renal disease care that black and white men received were statistically significant (RR, 0.39-0.97), with black men consistently receiving worse care. For some measures of management of end-stage renal disease, Asian men received care that was similar to or better than that received by non-Hispanic whites. CONCLUSION: Minority men are at a markedly elevated risk for the receipt of poor health care quality. However, generalizations about 'minority' men are likely to be misleading and incomplete. There is a considerable variation in the magnitude, direction, and significance of these risks.
SN - 0025-7079
AD - Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD; kfelix-aaron@hrsa.gov
U2 - PMID: 15746594.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Murashov
AU - V. V.
T1 - Reconstruction of Pristine and Hydrolyzed Quartz Surfaces.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2005/03/03/
VL - 109
IS - 9
M3 - Article
SP - 4144
EP - 4151
SN - 15206106
AB - Reconstruction of the most common pristine and hydrolyzed surfaces of quartz was investigated with periodic density functional theory calculations. Surface energies of reconstructed pristine faces, pertinent to quartz growth morphologies in melts, are found to range from 0.071 eV/Å2 for the (101) surface to 0.139 eV/Å2 for the (001) surface, and they increase as (101) < (102) < (112) < [(100), (111)] < (110) < (001). Four types of reconstruction reactions are observed: (1) formation of two-membered rings from vicinal silyl and siloxy sites, (2) formation of a pair of tricoordinated/unicoordinated oxygen atoms, (3) formation of three-membered rings, and (4) transformation of silanone sites into siloxane sites. The main features of reconstructed pristine quartz surfaces are two-membered rings formed from bridged siloxy and silyl sites on all investigated surfaces, a stable site complex with geminal positively charged tricoordinated and negatively charged unicoordinated oxygen atoms revealed on the (112) surface, and charged nonbridged siloxy/silyl sites, which are more stable than radical siloxy/silyl sites. Hydrolyzed surface energies range from −0.010 eV/Å2 for the (001) surface to 0.002 eV/Å2 for the (101) surface and increase as (001) < (110) < (102) < (111) < (100) < (112) < (101). The hydrolyzed surface stability is found to depend strongly on inter-site silanol hydrogen bonding. Observed networks of hydrogen bonds are important for interactions between silica surfaces and biomolecules in an aqueous environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUARTZ
KW - HYDROGEN bonding
KW - SURFACE energy
KW - SURFACE chemistry
N1 - Accession Number: 21814452; Murashov V. V. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Mar2005, Vol. 109 Issue 9, p4144; Subject Term: QUARTZ; Subject Term: HYDROGEN bonding; Subject Term: SURFACE energy; Subject Term: SURFACE chemistry; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Peilin
AU - Gao, Weiyi
AU - Li, Hongli
AU - Reed, Eddie
AU - Chen, Fei
T1 - Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/03/11/
VL - 328
IS - 2
M3 - Article
SP - 567
EP - 572
SN - 0006291X
AB - Abstract: Checkpoint kinase 2 (Chk2) is one of the critical kinases governing the cell cycle checkpoint, DNA damage repair, and cell apoptosis in response to DNA damaging signals. In the present report, we demonstrate that Chk2 kinase is degraded at the protein level in response to cisplatin through ubiquitin–proteasome pathway. This degradation was independent of the Thr68 phosphorylation, ATM kinase, and BRCA1 tumor suppressor. Examination of Chk2 protein revealed a decreased expression of Chk2 protein in cisplatin-resistant ovarian cancer cell lines, suggesting that degradation or decreased expression of Chk2 is partially responsible for chemo-resistance. Site-directed mutation of the putative destruction box in the Chk2 protein did not affect the Chk2 degradation induced by cisplatin. Therefore, these results are the first to indicate a novel mechanism of regulating Chk2 in cisplatin-induced resistance of cancer cells. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALKYLATING agents
KW - ANTINEOPLASTIC agents
KW - NUCLEIC acids
KW - BIOCHEMICAL genetics
KW - Cancer
KW - Chk2 kinase
KW - Cisplatin resistance
KW - Degradation
KW - Ubiquitination
N1 - Accession Number: 16292034; Zhang, Peilin 1,2 Gao, Weiyi 1 Li, Hongli 1 Reed, Eddie 2 Chen, Fei 1,3; Email Address: lfd3@cdc.gov; Affiliation: 1: Department of Pathology, West Virginia University, Morgantown, WV 26506, USA 2: Mary Baab Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA 3: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Mar2005, Vol. 328 Issue 2, p567; Subject Term: ALKYLATING agents; Subject Term: ANTINEOPLASTIC agents; Subject Term: NUCLEIC acids; Subject Term: BIOCHEMICAL genetics; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Chk2 kinase; Author-Supplied Keyword: Cisplatin resistance; Author-Supplied Keyword: Degradation; Author-Supplied Keyword: Ubiquitination; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.01.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bolan, R.
AU - Amezola, P.
AU - Kerndt, P.
AU - Soreth, J.
AU - Taylor, M.
AU - Heffelfinger, J.
AU - Weinstock, H.
AU - Greenberg, M.
AU - Janowski, M.
T1 - Inadvertent Use of Bicillin® C-R to Treat Syphilis Infection -- Los Angeles, California, 1999-2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/03/11/
VL - 54
IS - 9
M3 - Article
SP - 217
EP - 219
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the investigation of the misuse of Bicillin C-R at a clinic serving the GLBT community in Los Angeles, California from January 1999 to March 2004. Products containing benzathine penicillin G which are being marketed by Monarch Pharmaceuticals; Number of patients who were treated with Bicillin C-R for confirmed syphilis infection at the clinic; Purpose of developing a standard protocol for the patients.
KW - MEDICATION abuse
KW - PENICILLIN
KW - CLINICS
KW - SYPHILIS
KW - LOS Angeles (Calif.)
KW - CALIFORNIA
KW - MONARCH Pharmaceuticals Inc.
N1 - Accession Number: 16371144; Bolan, R. 1 Amezola, P. 1 Kerndt, P. 2 Soreth, J. 3 Taylor, M. 4 Heffelfinger, J. 4 Weinstock, H. 4 Greenberg, M. 5 Janowski, M. 5; Affiliation: 1: Los Angeles Gay and Lesbian Center 2: Los Angeles County Department of Health Services, California 3: Food and Drug Administration 4: Division of STD Prevention, National Center for HIV, STD, and TB Prevention 5: EIS officer, CDC; Source Info: 3/11/2005, Vol. 54 Issue 9, p217; Subject Term: MEDICATION abuse; Subject Term: PENICILLIN; Subject Term: CLINICS; Subject Term: SYPHILIS; Subject Term: LOS Angeles (Calif.); Subject Term: CALIFORNIA; Company/Entity: MONARCH Pharmaceuticals Inc. DUNS Number: 932915242; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Stryer, Daniel
AU - Clancy, Carolyn
T1 - Patients' safety.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2005/03/12/
VL - 330
IS - 7491
M3 - Editorial
SP - 553
EP - 554
SN - 09598146
AB - Discusses medical errors causing preventable deaths worldwide. Impact of medical error on ten percent of patients admitted to hospitals in the United Kingdom annually; Statistics of other hospital systems worldwide; Implementation of reporting systems that will shed additional light on threats to safety; Lack of substantial progress in culture to encompass commitment to open communication about errors to encourage reporting and analysis.
KW - MEDICAL personnel
KW - MEDICAL errors
KW - MEDICATION errors
KW - MEDICAL personnel -- Malpractice
KW - PATIENTS -- Safety measures
KW - HOSPITALS
KW - GREAT Britain
N1 - Accession Number: 16399556; Stryer, Daniel 1 Clancy, Carolyn 1; Affiliation: 1: Center for Quality Improvement and Patient Safety, US Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; Source Info: 3/12/2005, Vol. 330 Issue 7491, p553; Subject Term: MEDICAL personnel; Subject Term: MEDICAL errors; Subject Term: MEDICATION errors; Subject Term: MEDICAL personnel -- Malpractice; Subject Term: PATIENTS -- Safety measures; Subject Term: HOSPITALS; Subject Term: GREAT Britain; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106533201
T1 - Patients' safety: progress is elusive because culture in health care has not changed.
AU - Stryer D
AU - Clancy C
Y1 - 2005/03/12/
N1 - Accession Number: 106533201. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866.
KW - Patient Safety
KW - Quality Assurance
KW - Treatment Errors -- Prevention and Control
KW - Great Britain
KW - Medical Practice, Evidence-Based
KW - United States
SP - 553
EP - 554
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
JA - BMJ
VL - 330
IS - 7491
PB - BMJ Publishing Group
SN - 0959-8146
AD - Director, Center for Quality Improvement and Patient Safety, US Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850
U2 - PMID: 15760975.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106533201&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mei, N.
AU - Guo, L.
AU - Fu, P. P.
AU - Heflich, R. H.
AU - Chen, T.
T1 - Mutagenicity of comfrey (Symphytum Officinale) in rat liver.
JO - British Journal of Cancer
JF - British Journal of Cancer
Y1 - 2005/03/14/
VL - 92
IS - 5
M3 - Article
SP - 873
EP - 875
PB - Nature Publishing Group
SN - 00070920
AB - Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumorigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant.British Journal of Cancer (2005) 92, 873-875. doi:10.1038/sj.bjc.6602420 www.bjcancer.com Published online 22 February 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Cancer is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMFREY
KW - LIVER
KW - MUTAGENESIS
KW - BORAGINACEAE
KW - MUTATION (Biology)
KW - RATS
KW - cll gene
KW - comfrey
KW - pyrrolizidine alkaloid
KW - tandem base substitution
KW - transgenic rat
N1 - Accession Number: 16336253; Mei, N. 1 Guo, L. 2 Fu, P. P. 3 Heflich, R. H. 1 Chen, T. 1; Email Address: tchen@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA. 2: Center for Hepatotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. 3: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.; Source Info: 3/14/2005, Vol. 92 Issue 5, p873; Subject Term: COMFREY; Subject Term: LIVER; Subject Term: MUTAGENESIS; Subject Term: BORAGINACEAE; Subject Term: MUTATION (Biology); Subject Term: RATS; Author-Supplied Keyword: cll gene; Author-Supplied Keyword: comfrey; Author-Supplied Keyword: pyrrolizidine alkaloid; Author-Supplied Keyword: tandem base substitution; Author-Supplied Keyword: transgenic rat; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 3p; Document Type: Article
L3 - 10.1038/sj.bjc.6602420
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berthold, Inge
AU - Pombo, Maria-Luz
AU - Wagner, Leslie
AU - Arciniega, Juan L.
T1 - Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants
JO - Vaccine
JF - Vaccine
Y1 - 2005/03/14/
VL - 23
IS - 16
M3 - Article
SP - 1993
EP - 1999
SN - 0264410X
AB - Abstract: The only US-licensed anthrax vaccine for human use, as well as several experimental vaccines containing solely purified recombinant protective antigen (rPA), are formulated using aluminum hydroxide (Al(OH)3) as an adjuvant. It has been suggested that effective adjuvanticity of aluminum salts for protein antigens depends, at least partially, on the degree of adsorption of the antigen to the adjuvant. On the other hand, the ease of antigen desorption from the adjuvant in a quantitative fashion may facilitate the assessment of vaccine characteristics in the laboratory. In this regard, aluminum phosphate (AlPO4), although deemed a “weaker” adjuvant than Al(OH)3, appears superior to the latter. To investigate the possibility of formulating rPA vaccines with AlPO4, as well as the significance of the adsorption of this antigen to the aluminum salt for adjuvanticity, we studied the effect of AlPO4 and Al(OH)3 on the induction of anti-rPA antibodies in mice. In a first immunization experiment the adjuvanticity of AlPO4 combined with rPA was examined. Antibodies against rPA were measured using an ELISA. Results indicated that AlPO4 is able to significantly increase the antibody response to rPA, irrespective of its degree of adsorption to the adjuvant. Based on these results, in a second experiment mice were immunized twice, with different formulations of rPA containing either AlPO4 or Al(OH)3, and rPA-antibodies were measured using ELISA and an in vitro toxin neutralization assay. Comparable immune responses to rPA were obtained with both aluminum salts. Additionally, results with AlPO4 as adjuvant confirmed that, in this mouse model, binding of the protein to the adjuvant is not essential for adjuvanticity, whereas the amount of adjuvant has an influence on the antibody response induced. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Immunogenetics
KW - Anthrax
KW - Aluminum hydroxide
KW - Aluminum-containing adjuvant
KW - Anthrax vaccine
KW - Immunogenicity
KW - Mice
N1 - Accession Number: 16596785; Berthold, Inge 1; Email Address: ingeberthold@web.de; Pombo, Maria-Luz 2; Email Address: mariluzpombo@telcel.net.ve; Wagner, Leslie 1; Arciniega, Juan L. 1; Email Address: Arciniega@cber.fda.gov; Affiliations: 1: Center for Biologics Evaluation and Research, US FDA, CBER/DBPAP [HFM-443], 1401 Rockville Pike, Rockville, MD 20852, USA; 2: National Institute of Hygiene “Rafael Rangel”, Venezuela, Maria-Luz Pombo, Instituto Nacional de Higiene “Rafael Rangel”, Ciudad Universitaria, Los Chaguaramos, Caracas 1051, Venezuela; Issue Info: Mar2005, Vol. 23 Issue 16, p1993; Thesaurus Term: Antigens; Subject Term: Immunogenetics; Subject Term: Anthrax; Subject Term: Aluminum hydroxide; Author-Supplied Keyword: Aluminum-containing adjuvant; Author-Supplied Keyword: Anthrax vaccine; Author-Supplied Keyword: Immunogenicity; Author-Supplied Keyword: Mice; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.10.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106645731
T1 - Risk of mortality with a bloodstream infection is higher in the less severely ill at admission.
AU - Kim PW
AU - Perl TM
AU - Keelaghan EF
AU - Langenberg P
AU - Perencevich EN
AU - Harris AD
AU - Song X
AU - Roghmann M
Y1 - 2005/03/15/
N1 - Accession Number: 106645731. Language: English. Entry Date: 20050610. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Acute Physiology and Chronic Health Evaluation II (APACHE II). Grant Information: Grant #UR8/CCU315092-03 from the Center for Disease Control and Prevention for Epicenters for the Prevention of Health care-associated Infections. NLM UID: 9421642.
KW - Hospital Mortality -- Risk Factors
KW - Sepsis -- Mortality
KW - Severity of Illness
KW - Adult
KW - Aged
KW - Apache
KW - Chi Square Test
KW - Confidence Intervals
KW - Cox Proportional Hazards Model
KW - Critical Care
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Intensive Care Units
KW - Length of Stay
KW - Male
KW - Mantel-Haenszel Test
KW - Maryland
KW - Microbial Culture and Sensitivity Tests
KW - Middle Age
KW - Patient Admission
KW - Prospective Studies
KW - Record Review
KW - Relative Risk
KW - Sepsis -- Prevention and Control
KW - T-Tests
KW - Human
SP - 616
EP - 620
JO - American Journal of Respiratory & Critical Care Medicine
JF - American Journal of Respiratory & Critical Care Medicine
JA - AM J RESPIR CRIT CARE MED
VL - 171
IS - 6
CY - New York, New York
PB - American Thoracic Society
AB - Rationale: Health care--associated bloodstream infections are common in critically ill patients; however, investigators have had difficulty in quantifying the clinical impact of these infections given the high expected mortality among these patients. Objective: To estimate the impact of health care--associated bloodstream infections on in-hospital mortality after adjusting for severity of illness at critical care admission. Method: A cohort of medical and surgical intensive care unit patients. Measurements: Severity of illness at admission, bloodstream infection, and in-hospital mortality. Main Results: Among the 2,783 adult patients, 269 developed unit-associated bloodstream infections. After adjusting for severity of illness, patients with a lower initial severity of illness who developed an infection had a greater than twofold higher risk for in-hospital mortality (hazard ratio [HR] = 2.42, 95% confidence interval [CI] 1.70, 3.44) when compared with patients without infection and with a similar initial severity of illness. In contrast, patients with a higher initial severity of illness who subsequently developed an infection did not have an increased risk for in-hospital mortality (HR = 0.96, 95%CI 0.76, 1.23) when compared with patients without infection but with a similar initial severity of illness. Conclusions: These results suggest that these infections in less ill patients have a higher attributable impact on subsequent mortality than in more severely ill patients. Focusing interventions to prevent bloodstream infections in less severely ill patients would be expected to have a greater benefit in terms of mortality reduction.
SN - 1073-449X
AD - Food and Drug Administration, Division of Anti-Infective Drug Products, Rockville, MD
U2 - PMID: 15591469.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lin Lin
AU - Yong Qian
AU - Xianglin Shi
AU - Yan Chen
T1 - Induction of a Cell Stress Response Gene RTP801 by DNA Damaging Agent Methyl Methanesulfonate through CCAAT/Enhancer Binding Protein.
JO - Biochemistry
JF - Biochemistry
Y1 - 2005/03/15/
VL - 44
IS - 10
M3 - Article
SP - 3909
EP - 3914
SN - 00062960
AB - RTP801 is a newly discovered stress response gene that is induced by hypoxia and other cell stress signals. Here, we investigated the mechanism by which a DNA damaging agent, methyl methanesulfonate (MMS), induces RTP801 transcription, in HaCaT human keratinocytes, MMS was able to induce a rapid increase in the mRNA level of RTP801. Correspondingly, MMS treatment was capable of stimulating a 2.5 kb RTP801 promoter. Deletion studies with the promoter demonstrated a critical region between -1057 and -981 bp of the promoter that is responsive to MMS treatment. Point mutations of the consensus Elk- I and C/EBP sites within this region were able to abrogate the stimulatory effect of MMS, indicating that Elk-I and CIEBP are both involved in the transcriptional regulation of the RTP8041 gene by MMS. Furthermore, a gel mobility shift assay revealed that MMS was able to initiate rapid formation of a protein complex that bound the C/EBP site of the promoter. In addition, an anti-C/EBP/β antibody was capable of further shifting the bound protein complex. Therefore, these studies indicate that RTP801 is a transcriptional target of MMS in human keratinocytes and that C/EBP is implicated in transcriptional control of the gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - METHANESULFONATES
KW - ORGANOSULFUR compounds
KW - CARRIER proteins
KW - KERATINOCYTES
KW - MESSENGER RNA
N1 - Accession Number: 16456064; Lin Lin 1 Yong Qian 2 Xianglin Shi 2,3 Yan Chen 1,3; Email Address: ychen3@iupui.edu; Affiliation: 1: Department of Medical and Molecular Genetics, Walther Oncology Center, Indiana University School of Medicine and Walther Cancer Institute, Indianapolis. Indiana 46202. 2: Pathology and Physiology Research Branch, National institute for Occupational Safety and Health, Morgantown, West Virginia 26505. 3: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Source Info: 3/15/2005, Vol. 44 Issue 10, p3909; Subject Term: NUCLEIC acids; Subject Term: METHANESULFONATES; Subject Term: ORGANOSULFUR compounds; Subject Term: CARRIER proteins; Subject Term: KERATINOCYTES; Subject Term: MESSENGER RNA; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Millar, Eugene V.
AU - LO'Brien, Katherine
AU - Watt, James P.
AU - Lingappa, Jairam
AU - Pallipamu, Ravi
AU - Rosenstein, Nancy
AU - Hu, Diana
AU - Reid, Raymond
AU - Santosham, Mathuram
T1 - Epidemiology of Invasive Haemophilus influenzae Type A Disease among Navajo and White Mountain Apache Children, 1988-2003.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/03/15/
VL - 40
IS - 6
M3 - Article
SP - 823
EP - 830
SN - 10584838
AB - Background. Before the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, rates of H. influenzae disease among Navajo and White Mountain Apache (WMA) children were among the highest reported worldwide. Routine Hib vaccination has significantly reduced rates of Hib disease in these populations. As Hib disease rates decrease to very low levels, there are concerns that non-type b strains of H. influenzae may emerge as more prevalent causes of invasive disease in children. Methods. We reviewed population-based, active laboratory surveillance data from the period of 1988-2003 for invasive H. influenzae type a (Hia) disease among Navajo and WMA children aged <5 years. Clinical information on cases was collected by chart review. A sample of Hia isolates from Navajo children was typed by pulsed-field gel electrophoresis (PFGE). Results. During 1988-2003, a total of 76 reported cases of invasive Hia disease occurred among Navajo and WMA children. The overall annual incidence was 20.2 cases per 100,000 population aged <5 years. There was no increase in Hia disease rates after Hib vaccination was introduced. The median age of patients was 12 months. Meningitis (50% of cases) was the most common presentation, followed by pneumonia (27.6%). Two children with Hia disease died. PFGE analysis revealed a limited genetic diversity of Hia strains in this population. Conclusions. Active surveillance data showed high rates of invasive Hia disease among Navajo and WMA children but no increase in the incidence after Hib vaccination was introduced. The presentation of Hia disease is similar to that of Hib disease in the prevaccine era. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Communicable diseases -- Transmission
KW - Vaccination
KW - Haemophilus diseases
KW - Navajo children
KW - Juvenile diseases
N1 - Accession Number: 16261271; Millar, Eugene V. 1; Email Address: emillar@jhsph.edu; LO'Brien, Katherine 1; Watt, James P. 1; Lingappa, Jairam 2,3; Pallipamu, Ravi 4; Rosenstein, Nancy 2; Hu, Diana 5; Reid, Raymond 1; Santosham, Mathuram 1; Affiliations: 1: Center for American Indian Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; 2: Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; 3: Department of Medicine, University of Washington, Seattle.; 4: Washington State Department of Health, Public Health Laboratories, Shoreline, Washington; 5: Navajo Area Indian Health Service, Tuba City Indian Medical Center, Tuba City, Arizona; Issue Info: 3/15/2005, Vol. 40 Issue 6, p823; Thesaurus Term: Epidemiology; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Vaccination; Subject Term: Haemophilus diseases; Subject Term: Navajo children; Subject Term: Juvenile diseases; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brass, Clint
AU - Lubran, Robert
AU - Mastello, Albert
T1 - Letters.
JO - Government Executive
JF - Government Executive
J1 - Government Executive
PY - 2005/03/15/
Y1 - 2005/03/15/
VL - 37
IS - 4
M3 - Article
SP - 10
EP - 10
PB - National Journal Group, Inc.
SN - 00172626
AB - Presents letters to the editor referencing articles which have been published in previous editions. Discussion on performance information and program evaluations in the context of budget cycle decisions; "The Big Squeeze" and "The Red Zone," which were published in the February 2005 edition; "Uh Oh!," which was published in the January 2005 edition.
KW - GOVERNMENT executives
KW - BUREAUCRACY
KW - PERFORMANCE
KW - CIVIL service
KW - PUBLIC officers
KW - BUDGET
N1 - Accession Number: 16411478; Source Information: 3/15/2005, Vol. 37 Issue 4, p10; Subject Term: GOVERNMENT executives; Subject Term: BUREAUCRACY; Subject Term: PERFORMANCE; Subject Term: CIVIL service; Subject Term: PUBLIC officers; Subject Term: BUDGET; Subject Term: ; Number of Pages: 2/3p; ; Document Type: Article; ; Full Text Word Count: 507;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Heck, Diane E.
AU - Kagan, Valerian E.
AU - Shvedova, Anna A.
AU - Laskin, Jeffrey D.
T1 - An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis
JO - Toxicology
JF - Toxicology
Y1 - 2005/03/15/
VL - 208
IS - 2
M3 - Article
SP - 259
EP - 271
SN - 0300483X
AB - Abstract: Mitochondria play a central role in the life and death of cells. These organelles serve as the major energy-producing powerhouse, whereby the generation of ATP is associated with the utilization of molecular oxygen. A significant fraction (2–3%) of molecular oxygen consumed by mitochondria may be reduced in a one-electron fashion to yield a series of reactive oxygen species (ROS) such as superoxide anion radical, hydrogen peroxide, and hydroxyl radical. ROS are capable of damaging components of the electron transport apparatus and can, in turn, disrupt mitochondrial functioning, limiting cellular ATP levels and ultimately resulting in cell death. ROS-induced disruption of electron transport can perpetuate production of deleterious ROS and propagate mitochondrial damage. Consequently, mitochondria are highly enriched with water-soluble and lipid-soluble antioxidants (glutathione, ascorbate, Vitamin E, and coenzyme Q) and antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, catalase, thioredoxins, and peroxiredoxin. Another important antioxidant acting as a very effective scavenger of reactive lipid (peroxyl, alkoxyl) radicals is nitric oxide (NO) generated by mitochondrial nitric oxide synthase. However, NO can also be very disruptive to mitochondria function, a process facilitated by its high reactivity with superoxide. This interaction results in the formation of peroxynitrite, an oxidant capable of causing oxidative/nitrosative stress, further aggravating mitochondrial dysfunction, causing ATP depletion and damage to cells. Thus, in the most general sense, the effects of NO in mitochondria may be either protective or deleterious depending on specific conditions of local redox environment (redox potential, ratio of oxidized to reduced glutathione, transition metals, and the presence of other oxygen- and nitrogen-centered radicals). [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITRIC oxide
KW - MITOCHONDRIA
KW - ADENOSINE triphosphate
KW - ACTIVE oxygen
KW - Apoptosis
KW - Nitric oxide
KW - Phosphatidylserine
N1 - Accession Number: 16290851; Heck, Diane E. 1; Email Address: heck@eohsi.rutgers.edu Kagan, Valerian E. 2 Shvedova, Anna A. 3 Laskin, Jeffrey D. 4; Affiliation: 1: Departments of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA 2: Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA 3: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 4: Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA; Source Info: Mar2005, Vol. 208 Issue 2, p259; Subject Term: NITRIC oxide; Subject Term: MITOCHONDRIA; Subject Term: ADENOSINE triphosphate; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: Phosphatidylserine; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.tox.2004.11.027
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Yu-Ping
AU - Yan, Jian
AU - Fu, Peter P.
AU - Chou, Ming W.
T1 - Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2005/03/15/
VL - 155
IS - 3
M3 - Article
SP - 411
EP - 420
SN - 03784274
AB - Abstract: Retronecine-based pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline, are toxic to domestic livestock and carcinogenic to laboratory rodents. Previous in vitro metabolism studies showed that (±)6,7-dihydro-7-hydroxy-1-(hydroxymethyl)-5H-pyrrolizine (DHP) and pyrrolizidine alkaloid N-oxides were the major metabolites of these compounds. DHP is the reactive metabolite of pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides are generally regarded as detoxification products. However, a previous study of rat liver microsomal metabolism of riddelliine N-oxide demonstrated that DHP and its parent compound, riddelliine, were generated as the major metabolites of riddelliine N-oxide. In this study the metabolic activation of the three retronecine-based pyrrolizidine alkaloid N-oxides by human liver microsomes is investigated under oxidative and hypoxic conditions. Results shows that both the DHP and the corresponding parent pyrrolizidine alkaloids are the major metabolites of the human liver microsomal metabolism of pyrrolizidine alkaloid N-oxides. Under oxidative conditions, reduction of the N-oxide to pyrrolizidine alkaloid is inhibited and while under hypoxic conditions, DHP formation is dramatically decreased. The oxidative and reductive products generated from the metabolism of pyrrolizidine alkaloid N-oxides are substrate-, enzyme- and time-dependent. In the presence of troleandomycin, a microsomal CYP3A inhibitor, DHP formation is inhibited by more than 70%, while the N-oxide reduction was not affected. The level of microsomal enzyme activity in human liver is comparable with rats. The rate of in vitro metabolism by either human and rat liver microsomes follows the order of riddelliine≥retrorsine>monocrotaline, and DHP-derived DNA adducts are detected and quantified by 32P-postlabeling/HPLC analysis. Similar DHP-derived DNA adducts are found in liver DNA of F344 rats gavaged with the pyrrolizidine alkaloid N-oxides (1.0mg/kg). The levels of in vivo DHP-DNA adduct formation is correlated with the level of in vitro DHP formation. Our results indicate that pyrrolizidine alkaloid N-oxides may be hepatocarcinogenic to rats through a genotoxic mechanism via the conversion of the N-oxides to their corresponding parent pyrrolizidine alkaloids, and these results may be relevant to humans. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Organonitrogen compounds
KW - Biliary tract
KW - Liver
KW - Pyrrolizidines
KW - 32P-postlabeling
KW - Dehydroretronecine
KW - DNA adducts
KW - Human liver microsomal metabolism
KW - Monocrotaline
KW - Monocrotaline N-oxide
KW - Pyrrolizidine alkaloid
KW - Retrorsine
KW - Retrorsine N-oxide
KW - Riddelliine
KW - Riddelliine N-oxide
N1 - Accession Number: 22230206; Wang, Yu-Ping 1; Yan, Jian 1; Fu, Peter P. 1; Chou, Ming W.; Email Address: mchou@nctr.fda.gov; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079 USA; Issue Info: Mar2005, Vol. 155 Issue 3, p411; Thesaurus Term: Organonitrogen compounds; Subject Term: Biliary tract; Subject Term: Liver; Subject Term: Pyrrolizidines; Author-Supplied Keyword: 32P-postlabeling; Author-Supplied Keyword: Dehydroretronecine; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Human liver microsomal metabolism; Author-Supplied Keyword: Monocrotaline; Author-Supplied Keyword: Monocrotaline N-oxide; Author-Supplied Keyword: Pyrrolizidine alkaloid; Author-Supplied Keyword: Retrorsine; Author-Supplied Keyword: Retrorsine N-oxide; Author-Supplied Keyword: Riddelliine; Author-Supplied Keyword: Riddelliine N-oxide; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.toxlet.2004.11.010
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Purdy, David E.
AU - Chang, Gwong-Jen J.
T1 - Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein
JO - Virology
JF - Virology
Y1 - 2005/03/15/
VL - 333
IS - 2
M3 - Article
SP - 239
EP - 250
SN - 00426822
AB - Abstract: DNA plasmids that express flavivirus premembrane/membrane (prM/M) and envelope (E) proteins in the form of virus-like particles (VLPs) have an excellent potential as DNA vaccine candidates against virus infection. The plasmid-expressed VLPs are also useful as safe, noninfectious antigens in serodiagnostic assays. We have constructed plasmids containing the prM/M and E gene regions for DENV-1, -3, and -4 that express and secrete VLPs when electroporated into Chinese hamster ovary cells. Constructs containing the full-length DENV-1 E protein gene did not secrete VLPs into tissue culture fluid effectively. However, a 16-fold increase in ELISA titers of DENV-1 VLPs was achieved after replacing the carboxy-terminal 20% region of DENV-1 E protein gene with the corresponding sequence of Japanese encephalitis virus (JEV). DENV-3 plasmids containing either the full-length DENV-3 E protein gene or the 20% JEV sequence replacement secreted VLPs to similarly high levels. Whereas DENV-4 VLPs were secreted to high levels by plasmids containing the full-length DENV-4 E protein gene but not by the chimeric plasmid containing 20% JEV E replacement. Domain substitutions by replacing prM/M protein stem-anchor region with the corresponding prM/M stem-anchor region of JEV or DENV-2 in the chimeric DENV-4 construct failed to promote the secretion of DENV-4 VLPs. Using the DENV-2 chimeric plasmid with carboxy-terminal 10% of JEV E gene, the sequence responsible for intracellular localization of E protein was mapped onto the E-H1 α-helix domain of DENV-2 E protein. Substitution of three amino acids from the DENV-2 sequence to the corresponding amino acids in the JEV sequence (I398L, M401A, and M412L) in the E-H1 was sufficient to promote extracellular secretion and resulted in detectable titers of DENV-2 VLP secretion. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - PLASMIDS
KW - DNA vaccines
KW - TISSUE culture
KW - Dengue virus
KW - prM-E-expressing plasmids
KW - Stem-anchor regions
KW - Virus-like particles
N1 - Accession Number: 16513057; Purdy, David E. 1 Chang, Gwong-Jen J.; Email Address: gxc7@cdc.gov; Affiliation: 1: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA; Source Info: Mar2005, Vol. 333 Issue 2, p239; Subject Term: DENGUE viruses; Subject Term: PLASMIDS; Subject Term: DNA vaccines; Subject Term: TISSUE culture; Author-Supplied Keyword: Dengue virus; Author-Supplied Keyword: prM-E-expressing plasmids; Author-Supplied Keyword: Stem-anchor regions; Author-Supplied Keyword: Virus-like particles; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.virol.2004.12.036
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Hakimian, Rina
AU - Korn, David
T1 - Ownership and Use of Tissue Specimens for Research—Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/03/16/
VL - 293
IS - 11
M3 - Letter
SP - 1325
EP - 1326
SN - 00987484
AB - Presents a reply by Rina Hakimian and David Korn to a letter to the editor about their article "Ownership and use of tissue specimens for research."
KW - LETTERS to the editor
KW - TISSUES
KW - RESEARCH
KW - Ethics, Medical
KW - Informed Consent
KW - Patient Rights
KW - Tissue Donors
N1 - Accession Number: 16401516; Hakimian, Rina 1; Email Address: rina.hakimian@psc.hhs.gov Korn, David 2; Affiliation: 1: US Department of Health and Human Services, Rockville, MD 2: Division of Biomedical and Health Sciences Research Association of American Medical Colleges, Washington, DC; Source Info: 3/16/2005, Vol. 293 Issue 11, p1325; Subject Term: LETTERS to the editor; Subject Term: TISSUES; Subject Term: RESEARCH; Author-Supplied Keyword: Ethics, Medical; Author-Supplied Keyword: Informed Consent; Author-Supplied Keyword: Patient Rights; Author-Supplied Keyword: Tissue Donors; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Graham, David J.
AU - Staffa, Judy A.
AU - La Grenade, Lois
AU - Shatin, Deborah
AU - Schech, Stephanie D.
AU - Andrade, Susan E.
AU - Gurwitz, Jerry H.
AU - Goodman, Michael J.
AU - Chan, K. Arnold
AU - Platt, Richard
T1 - Rhabdomyolysis and Lipid-Lowering Drugs—Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/03/23/
VL - 293
IS - 12
M3 - Letter
SP - 1448
EP - 1449
SN - 00987484
AB - Presents a reply by David J. Graham, Judy A. Staffa, Lois La Grenade, Deborah Shatin, Stephanie D. Schech, Susan E. Andrade, Jerry H. Gurwitz, Michael J. Goodman, K. Arnold Chan, and Richard Platt, to a letter to the editor about their article, "Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs."
KW - LETTERS to the editor
KW - RHABDOMYOLYSIS
KW - Bezafibrate
KW - Clofibric Acid
KW - Drug Reaction, Adverse
KW - Fenofibrate see Procetofen
KW - Fibrates see Clofibric Acid
KW - Gemfibrozil
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW - Procetofen
KW - Rhabdomyolysis
KW - Statins, HMG-CoA see Hydroxymethylglutaryl-CoA Reductase Inhibitors
N1 - Accession Number: 16506545; Graham, David J. 1; Email Address: grahamd@cder.fda.gov Staffa, Judy A. 1 La Grenade, Lois 1 Shatin, Deborah 2 Schech, Stephanie D. 2 Andrade, Susan E. 3 Gurwitz, Jerry H. 3 Goodman, Michael J. 4 Chan, K. Arnold 5 Platt, Richard 5; Affiliation: 1: Office for Drug Safety, US Food and Drug Administration, Rockville, Md. 2: Center for Health Care Policy and Evaluation, Eden Prairie, Minn 3: Meyers Primary Care Institute, Worcester, Mass 4: Health Partners Research Foundation, Minneapolis, Minn 5: Harvard Medical School, Boston, Mass; Source Info: 3/23/2005, Vol. 293 Issue 12, p1448; Subject Term: LETTERS to the editor; Subject Term: RHABDOMYOLYSIS; Author-Supplied Keyword: Bezafibrate; Author-Supplied Keyword: Clofibric Acid; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Fenofibrate see Procetofen; Author-Supplied Keyword: Fibrates see Clofibric Acid; Author-Supplied Keyword: Gemfibrozil; Author-Supplied Keyword: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Author-Supplied Keyword: Procetofen; Author-Supplied Keyword: Rhabdomyolysis; Author-Supplied Keyword: Statins, HMG-CoA see Hydroxymethylglutaryl-CoA Reductase Inhibitors; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Norling, Lenore
AU - Lute, Scott
AU - Emery, Rachel
AU - Khuu, Wynn
AU - Voisard, Mark
AU - Xu, Yuan
AU - Chen, Qi
AU - Blank, Greg
AU - Brorson, Kurt
T1 - Impact of multiple re-use of anion-exchange chromatography media on virus removal
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2005/03/25/
VL - 1069
IS - 1
M3 - Article
SP - 79
EP - 89
SN - 00219673
AB - Abstract: We evaluated viral clearance in multiply-cycled anion-exchange media run in flow-through mode. We found that anion-exchange columns do not lose viral clearance capacity after extensive re-use, if they are cleaned with recommended buffers that do not chemically degrade the media. In contrast, anion-exchange (AEX) columns that are not cleaned or are cleaned with buffers that chemically degrade the media lost viral clearance capacity after extended use. In these cases, other performance attributes that changed at the same time were increased band spreading, decreased DNA clearance and accumulating backpressure that prevented re-use past 80–120 cycles. Thus, our data suggests that flow through mode anion-exchange columns that are cleaned with recommended cleaning buffers, and periodically monitored for band spreading, DNA clearance and/or backpressure need not be re-evaluated for viral clearance at the end of the validated media lifetime. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Viruses
KW - Chromatographic analysis
KW - Immunoglobulins
KW - DNA
KW - Anion-exchange media
KW - Bioprocessing
KW - Biotechnology
KW - Chromatography media lifetime
KW - Monoclonal antibodies
KW - Viral clearance
N1 - Accession Number: 17515093; Norling, Lenore 1; Lute, Scott 2; Emery, Rachel 1; Khuu, Wynn 1; Voisard, Mark 3; Xu, Yuan 1; Chen, Qi 1; Blank, Greg 1; Brorson, Kurt 2; Email Address: brorson@cber.fda.gov; Affiliations: 1: Department of Recovery Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA; 2: Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA; 3: Amersham Inc., 800 Centennial Ave., Piscataway, NJ 08855, USA; Issue Info: Mar2005, Vol. 1069 Issue 1, p79; Thesaurus Term: Viruses; Thesaurus Term: Chromatographic analysis; Subject Term: Immunoglobulins; Subject Term: DNA; Author-Supplied Keyword: Anion-exchange media; Author-Supplied Keyword: Bioprocessing; Author-Supplied Keyword: Biotechnology; Author-Supplied Keyword: Chromatography media lifetime; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: Viral clearance; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.chroma.2004.09.072
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Gu, Zu-Wei
AU - Keane, Michael J.
AU - Ong, Tong-man
AU - Wallace, William E.
T1 - Diesel Exhaust Particulate Matter Dispersed in a Phospholipid Surfactant Induces Chromosomal Aberrations and Micronuclei but not 6-Thioguanine-Resistant Gene Mutation in V79 Cells.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/03/26/
VL - 68
IS - 6
M3 - Abstract
SP - 431
EP - 444
SN - 15287394
AB - Diesel exhaust particulate material (DPM) was assayed for induction of chromosomal aberrations (CA), micronucleus (MN) formation, and 6-thioguanine-resistant (TG r ) gene mutation in V79 cells as a dispersion in dipalmitoyl phosphatidylcholine (DPPC) in physiological saline, a simulated pulmonary surfactant. Filter-collected automobile DPM provided for the study was not organic solvent extracted, but was directly mixed into DPPC in saline dispersion as a model of pulmonary surfactant conditioning of a soot particle depositing in a lung alveolus. A statistically significant difference was found between treated and control groups at all concentrations tested in a CA assay. Assay for MN induction also gave a positive response: Above 50 μg/ml, the frequencies of micronucleated cells (MNC) were about 2 times higher than those in the control group. The forward gene mutation assay did not show a positive response when cells were treated with up to 136 μg DPM/ml for 24 h, as dispersion in DPPC in saline. Some comparison assays were run on direct dispersions of the DPM into dimethyl sulfoxide, with results equivalent to those seen with a DPPC–saline preparation: DPM in dimethyl sulfoxide (DMSO) was positive for MN induction but was negative for forward gene mutation in V79 cells. The positive clastogenicity results are consistent with other studies of DPM dispersed into DPPC–saline surfactant that have shown activity in mammalian cells for sister chromatid exchange, unscheduled DNA synthesis, and MN induction. The forward gene mutation negative results are consistent with studies of that assay applied to V79 cells challenged with DPM solvent extract. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMOSOME abnormalities
KW - DIESEL motor exhaust gas
KW - MUTATION (Biology)
KW - PHOSPHOLIPIDS
KW - NUCLEOLUS
KW - SOLVENTS
N1 - Accession Number: 16336422; Gu, Zu-Wei 1 Keane, Michael J. 1 Ong, Tong-man 1 Wallace, William E. 1; Email Address: wwallace@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Source Info: 2005, Vol. 68 Issue 6, p431; Subject Term: CHROMOSOME abnormalities; Subject Term: DIESEL motor exhaust gas; Subject Term: MUTATION (Biology); Subject Term: PHOSPHOLIPIDS; Subject Term: NUCLEOLUS; Subject Term: SOLVENTS; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 14p; Document Type: Abstract
L3 - 10.1080/15287390590903676
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16336422&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stewart, Richard S.
AU - Piccardo, Pedro
AU - Ghetti, Bernardino
AU - Harris, David A.
T1 - Neurodegenerative Illness in Transgenic Mice Expressing a Transmembrane Form of the Prion Protein.
JO - Journal of Neuroscience
JF - Journal of Neuroscience
Y1 - 2005/03/30/
VL - 25
IS - 13
M3 - Article
SP - 3469
EP - 3477
SN - 02706474
AB - Although PrPSc is thought to be the infectious form of the prion protein, it may not be the form that is responsible for neuronal cell death in priori diseases. CtmPrP is a transmembrane version of the prion protein that has been proposed to be a neurotoxic intermediate underlying prion-induced pathogenesis. To investigate this hypothesis, we have constructed transgenic mice that express L9R-3AV PrP, a mutant prion protein that is synthesized exclusively in the CtmPrP form in transfected cells. These mice develop a fatal neurological illness characterized by ataxia and marked neuronal loss in the cerebellum and hippocampus. CtmPrP in neurons cultured from transgenic mice is localized to the Golgi apparatus, rather than to the endoplasmic reticulum as in transfected cell lines. Surprisingly, development of the neurodegenerative phenotype is strongly dependent on coexpression of endogenous, wild-type PrP. Our results provide new insights into the cell biology of CtmPrP, the mechanism by which it induces neurodegeneration, and possible cellular activities of PrPC. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neuroscience is the property of Society for Neuroscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - BIOMOLECULES
KW - CELL death
KW - CELLS
KW - DISEASES
KW - Golgi
KW - mutation
KW - neurodegeneration
KW - prion
KW - transgenic
KW - Transmembrane
N1 - Accession Number: 16816535; Stewart, Richard S. 1 Piccardo, Pedro 2,3 Ghetti, Bernardino 2 Harris, David A. 1; Email Address: dharris@cellbiology.wustl.edu; Affiliation: 1: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110 2: Division of Neuropathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852; Source Info: 3/30/2005, Vol. 25 Issue 13, p3469; Subject Term: PROTEINS; Subject Term: BIOMOLECULES; Subject Term: CELL death; Subject Term: CELLS; Subject Term: DISEASES; Author-Supplied Keyword: Golgi; Author-Supplied Keyword: mutation; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: prion; Author-Supplied Keyword: transgenic; Author-Supplied Keyword: Transmembrane; Number of Pages: 9p; Illustrations: 4 Color Photographs, 2 Black and White Photographs, 4 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1523/JNEUROSCI.0105-05.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kannamkumarath, Sasi S.
AU - Wrobel, Katarzyna
AU - Wuilloud, Rodolfo G.
T1 - Studying the distribution pattern of selenium in nut proteins with information obtained from SEC-UV-ICP-MS and CE-ICP-MS
JO - Talanta
JF - Talanta
Y1 - 2005/03/31/
VL - 66
IS - 1
M3 - Article
SP - 153
EP - 159
SN - 00399140
AB - Abstract: In this work, size exclusion chromatography (SEC) with UV and inductively coupled plasma mass spectrometry (ICP-MS) detection was used to study the association of selenium to proteins present in Brazil nuts (Bertholletia excelsa) under five different extraction conditions. As expected, better solubilization of proteins was observed using 0.05molL−1 sodium hydroxide and 1% sodium dodecylsulfate (SDS) in Tris/HCl buffer (0.05molL−1, pH 8) as compared to 0.05molL−1 HCl, 0.05molL−1 Tris/HCl or hot water (60°C). Due to non-destructive character of Tris-SDS treatment, this was applied for studying molecular weight (MW) distribution patterns of selenium-containing nut proteins. Three different SEC columns were used for obtaining complete MW distribution of selenium: Superdex 75, Superdex Peptide, and Superdex 200 were tested with 50mmolL−1 Tris buffer (pH 8), 150mmolL−1 ammonium bicarbonate buffer (pH 7.8), phosphate (pH 7.5), and CAPS (pH 10.0) mobile phases. Using Superdex 200 column, the elution of at least three MW fractions was observed with UV detection (200–10kDa) and ICP-MS chromatogram showed the co-elution of selenium with the two earlier fractions. The apparent MWs of these selenium-containing fractions were respectively about 107 and 50kDa, as evaluated from the column calibration. For further characterization of individual selenium species, the defatted nuts were hydrolyzed with proteinase K and analyzed by capillary electrophoresis (CE) with ICP-MS detection. The suitability of CE for the separation of selenite, selenate, selenocystine and selenomethionine in the presence of the nut sample matrix is demonstrated. Complete separation of the above mentioned selenium species was obtained within a migration time of 7min. In the analysis of nut extracts with CE-ICP-MS, selenium was found to be present mainly as selenomethionine. [Copyright &y& Elsevier]
AB - Copyright of Talanta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SELENIUM
KW - INDUCTIVELY coupled plasma mass spectrometry
KW - HYDROGEN-ion concentration
KW - NATIVE element minerals
KW - MASS spectrometry
KW - Brazil nuts
KW - CE-ICP-MS
KW - SEC-UV-ICP-MS
KW - Selenocystine
KW - Selenomethionine
KW - Selenoproteins
KW - Speciation
N1 - Accession Number: 17637974; Kannamkumarath, Sasi S. 1; Email Address: kannamkumass@ornl.gov Wrobel, Katarzyna 2 Wuilloud, Rodolfo G. 1,3; Affiliation: 1: Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA 2: Instituto de Investigaciones Cientificas, Universidad de Guanajuato, L. de Retana No. 5, 36000 Guanajuato, Mexico 3: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA; Source Info: Mar2005, Vol. 66 Issue 1, p153; Subject Term: SELENIUM; Subject Term: INDUCTIVELY coupled plasma mass spectrometry; Subject Term: HYDROGEN-ion concentration; Subject Term: NATIVE element minerals; Subject Term: MASS spectrometry; Author-Supplied Keyword: Brazil nuts; Author-Supplied Keyword: CE-ICP-MS; Author-Supplied Keyword: SEC-UV-ICP-MS; Author-Supplied Keyword: Selenocystine; Author-Supplied Keyword: Selenomethionine; Author-Supplied Keyword: Selenoproteins; Author-Supplied Keyword: Speciation; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.talanta.2004.10.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brinker, Allen
AU - Nourjah, Parivash
T1 - Patient characteristics associated with outpatient prescriptions for nabumetone and oxaprozin versus celecoxib and rofecoxib.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2005/04//4/1/2005
VL - 62
IS - 7
M3 - Article
SP - 739
EP - 743
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Presents characterization of patients associated with outpatient prescriptions for nabumetone and oxaprozin versus celecoxib and refocoxib. Identification of celecoxib and rofecoxib as the first two selective cyclooxygenase-2 (COX-2) receptor inhibitors in the market; Ability of inhibitors to produce less irritation to the GI system; Possible usage of celecoxib and rofecoxib in patients at high risk of GI adverse events.
KW - CYCLOOXYGENASE 2 -- Inhibitors
KW - CELECOXIB
KW - IMMUNOGLOBULINS
KW - BLOOD proteins
KW - ANTI-infective agents
KW - DRUGS -- Effectiveness
N1 - Accession Number: 16515804; Brinker, Allen 1; Email Address: brinkera@cder.fda.gov Nourjah, Parivash 2; Affiliation: 1: Medical Epidemiologist, Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD. 2: Epidemiologist, Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD.; Source Info: 4/1/2005, Vol. 62 Issue 7, p739; Subject Term: CYCLOOXYGENASE 2 -- Inhibitors; Subject Term: CELECOXIB; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD proteins; Subject Term: ANTI-infective agents; Subject Term: DRUGS -- Effectiveness; Number of Pages: 5p; Document Type: Article
L3 - 0620739.pdf
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mozzachio, Alicia M.
T1 - A world away.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2005/04//4/1/2005
VL - 62
IS - 7
M3 - Article
SP - 753
EP - 759
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Presents an authors experience during his deployment in Iraq to represent the pharmacy contingent of the Public Health Service (PHS). Development of regulations for imported drug products; Importance of the mission on public health and medical care; Realizations on the major role of the CPA-MOH team in building the health care system in Iraq.
KW - PUBLIC health
KW - HUMAN services
KW - MEDICAL care
KW - HEALTH education
KW - IRAQ
N1 - Accession Number: 16515790; Mozzachio, Alicia M. 1; Email Address: mozzachioa@cder.fda.gov; Affiliation: 1: Consumer Safety Officer, Foreign Inspection Team, Division of Manufacturing and Product Quality, Office of Compliance, Center for Drug Evaluation and Research, Food and Drug Administration, U.S. Public Health Service, Montrose Metro II, Room 415, 11919 Rockville Pike, Rockville, MD 20852; Source Info: 4/1/2005, Vol. 62 Issue 7, p753; Subject Term: PUBLIC health; Subject Term: HUMAN services; Subject Term: MEDICAL care; Subject Term: HEALTH education; Subject Term: IRAQ; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
L3 - 0620753.pdf
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106392101
T1 - Patient characteristics associated with outpatient prescriptions for nabumetone and oxaprozin versus celecoxib and rofecoxib.
AU - Brinker A
AU - Nourjah P
Y1 - 2005/04//4/1/2005
N1 - Accession Number: 106392101. Language: English. Entry Date: 20081219. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Cox-2 Inhibitors -- Adverse Effects
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Data Analysis Software
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Middle Age
KW - Office Visits
KW - Prescriptions, Drug
KW - Record Review
KW - Sampling Methods
KW - Surveys
KW - T-Tests
KW - Human
SP - 739
EP - 743
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 62
IS - 7
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Medical Epidemiologist, Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857; brinkera@cder.fda.gov
U2 - PMID: 15790802.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Scabilloni, James F.
AU - Liying Wang
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Castranova, Vincent
AU - Mercer, Robert R.
T1 - Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation' due to silica inhalation.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2005/04//
VL - 32
IS - 4
M3 - Article
SP - L709
EP - 717
SN - 10400605
AB - Matrix metalloproteinases (MMPs) are the principle enzymes that initiate degradation of collagen. We examined the role of MMPs during alveolar wall fibrosis and fibrotic nodule formation from silica exposure. Rats were exposed to filtered air or 15 mg/m³ silica by inhalation for 5 days/wk, 6 h/day. Lungs were preserved by intratracheal instillation of fixative at 20, 40, 60, 79, and 116 days of exposure. Additional groups were fixed after 20, 40, and 60 days of exposure followed by 36 days of recovery. The number of nodules, defined by a collagenous core and a bounding cell layer detached from the alveolar wall, was determined by morphometry. Lungs showed increased alveolar wall collagen and fibrotic nodules at 79 and 116 days of exposure with increased collagenase and gelatinase activity. The number of nodules per lung in exposed groups increased from 619 ± 447 at 40 days to 13,221 ± 1,096 at 116 days (means ± SE, n = 5). No nodules were seen in control lungs. Silica-exposed rats with a 36-day recovery in filtered air showed enhanced MMP activity over exposure to silica for the same duration with no recovery. MMP-2 and MMP-9 were significantly elevated in alveolar macrophages after 40-day exposure. Stromelysin expression was demonstrated in alveolar macrophages and cells within fibrotic nodules. TIMP-1 expression was not significantly altered. In summary, MMP activity was upregulated at 40 days of silica exposure and progressively increased during ensuing fibrotic responses. Early expression of stromelysin was found in fibrosing alveolar walls and fibrotic nodules. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALLOPROTEINASES
KW - COLLAGEN
KW - FIBROSIS
KW - SILICA
KW - SILICOSIS
KW - LUNGS
KW - lung
KW - remodeling
KW - silicosis
KW - stromelysin
N1 - Accession Number: 16571376; Scabilloni, James F. 1; Email Address: zbc9@cdc.gov Liying Wang 1 Antonini, James M. 1 Roberts, Jenny R. 1 Castranova, Vincent 1 Mercer, Robert R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Physiology and Pathology Research Branch, Morgantown, West Virginia; Source Info: Apr2005, Vol. 32 Issue 4, pL709; Subject Term: METALLOPROTEINASES; Subject Term: COLLAGEN; Subject Term: FIBROSIS; Subject Term: SILICA; Subject Term: SILICOSIS; Subject Term: LUNGS; Author-Supplied Keyword: lung; Author-Supplied Keyword: remodeling; Author-Supplied Keyword: silicosis; Author-Supplied Keyword: stromelysin; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 9p; Illustrations: 1 Color Photograph, 3 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1152/ajplung.00034.2004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oser, Carrie S.
AU - Harwell, Todd S.
AU - Strasheim, Carol
AU - Fogle, Crystelle
AU - Blades, Lynda L.
AU - Dennis, Terry D.
AU - Johnson, Elizabeth A.
AU - Gohdes, Dorothy
AU - Helgerson, Steven D.
T1 - Increasing prevalence of cardiovascular risk factors among American Indians in Montana
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2005/04//
VL - 28
IS - 3
M3 - Article
SP - 295
EP - 297
SN - 07493797
AB - Background: Cardiovascular disease (CVD) is the leading cause of death among American Indians. The objective of this study was to assess trends in CVD and CVD risk factors among American Indians in Montana. Methods: In 1999 and 2003, 1000 American Indian adults aged ≥18 years living on or near the seven reservations in Montana were interviewed each year using an adapted Behavior Risk Factor Surveillance System survey. Results: During the 5-year period from 1999 to 2003, the prevalence of CVD risk factors increased significantly: diabetes (12% to 16%), high blood pressure (26% to 34%), high cholesterol (23% to 30%), and obesity (34% to 39%). The percentage reporting current smoking was stable and remained high (38% to 36%). After adjusting for age and gender, the increases in high blood pressure, high cholesterol, and obesity remained significant. The percentage reporting two or more CVD risk factors increased significantly overall, among men and women, and among older and younger respondents during the 5-year time period. Conclusions: The prevalence of CVD risk factors among American Indian adults in Montana is high, and for many of the risk factors, has increased significantly over a 5-year period. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTENSION
KW - BLOOD pressure
KW - LOW-cholesterol diet
KW - CHOLESTEROL
N1 - Accession Number: 16737282; Oser, Carrie S. 1 Harwell, Todd S. 1; Email Address: tharwell@mt.gov Strasheim, Carol 2 Fogle, Crystelle 1 Blades, Lynda L. 1 Dennis, Terry D. 2 Johnson, Elizabeth A. 1 Gohdes, Dorothy 1 Helgerson, Steven D. 1; Affiliation: 1: Montana Department of Public Health and Human Services, Helena, Montana 2: Billings Area Indian Health Service, Billings, Montana; Source Info: Apr2005, Vol. 28 Issue 3, p295; Subject Term: HYPERTENSION; Subject Term: BLOOD pressure; Subject Term: LOW-cholesterol diet; Subject Term: CHOLESTEROL; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.amepre.2004.12.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shi, Leiyu
AU - Macinko, James
AU - Starfield, Barbara
AU - Politzer, Robert
AU - Wulu, John
AU - Xu, Jiahong
T1 - Primary Care, Social Inequalities, and All-Cause, Heart Disease, and Cancer Mortality in US Counties, 1990.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005/04//
VL - 95
IS - 4
M3 - Article
SP - 674
EP - 680
PB - American Public Health Association
SN - 00900036
AB - Objectives. We tested the association between the availability of primary care and income inequality on several categories of mortality in US counties. Methods. We used cross-sectional analysis of data from counties (n=3081) in 1990, including analysis of variance and multivariate ordinary least squares regression. Independent variables included primary care resources, income inequality, and sociodemographics. Results. Counties with higher availability of primary care resources experienced between 2% and 3% lower mortality than counties with less primary care. Counties with high income inequality experienced between 11% and 13% higher mortality than counties with less inequality. Conclusions. Primary care resources may partially moderate the effects of income inequality on health outcomes at the county level. (Am J Public Health. 2005;95:674-680.). [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY care (Medicine)
KW - MORTALITY
KW - PUBLIC health
KW - MEDICAL care costs
KW - INCOME distribution
KW - REGRESSION analysis
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 16584359; Shi, Leiyu 1; Email Address: lshi@jhsph.edu Macinko, James 2 Starfield, Barbara 3 Politzer, Robert 4 Wulu, John 4 Xu, Jiahong 3; Affiliation: 1: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. 2: Steinhardt School of Education, New York University, New York, NY. 3: Johns Hopkins Bloomberg School of Public Health 4: Bureau for Primary Care, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, Md.; Source Info: Apr2005, Vol. 95 Issue 4, p674; Subject Term: PRIMARY care (Medicine); Subject Term: MORTALITY; Subject Term: PUBLIC health; Subject Term: MEDICAL care costs; Subject Term: INCOME distribution; Subject Term: REGRESSION analysis; Subject Term: MEDICAL policy; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5778
L3 - 10.2105/AJPH.2003.031716
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Christine G. Parks
AU - Glinda S. Cooper
AU - Lori L. Hudson
AU - Mary Anne Dooley
AU - Edward L. Treadwell
AU - E. W. St.Clair
AU - Gary S. Gilkeson
AU - Janardan P. Pandey
T1 - Association of Epstein‐Barr virus with systemic lupus erythematosus: Effect modification by race, age, and cytotoxic T lymphocyte–associated antigen 4 genotype.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2005/04//
VL - 52
IS - 4
M3 - Article
SP - 1148
EP - 1159
SN - 00043591
AB - Epstein‐Barr virus (EBV) is hypothesized to play a role in the development of systemic lupus erythematosus (SLE). Cytotoxic T lymphocyte–associated antigen 4 (CTLA‐4) is important in regulating T cell–mediated immunity, encompassing the first line of response to viral infections, and genetic variation in CTLA‐4 has been associated with SLE. This study examined the seroprevalence of EBV in a population‐based study of SLE patients from the southeastern United States, and potential interactions with CTLA‐4 polymorphisms were assessed.Cases comprised 230 subjects recently diagnosed as having SLE (144 African American and 86 white) from university and community‐based clinics, and controls comprised 276 age‐, sex‐, and state‐matched subjects (72 African American and 204 white) recruited from driver''s license registries. Antibodies to EBV capsid antigen were determined by enzyme‐linked immunosorbent assay, with results expressed as positive or negative using the international standardized ratio (ISR) (a ratio of the sample absorbance to a known standard). CTLA‐4 genotypes were identified by polymerase chain reaction–based methods. In African Americans, EBV‐IgA seroprevalence was strongly associated with SLE (odds ratio [OR] 5.6, 95% confidence interval [95% CI] 3.0–10.6). In whites, the modest association of SLE with EBV‐IgA (OR 1.6) was modified by age, in that the strongest association was observed in those older than age 50 years (OR 4.1, 95% CI 1.6–10.4). The seroprevalence of EBV‐IgM and that of EBV‐IgG were not associated with SLE. Higher EBV‐IgG absorbance ratios were observed in SLE patients, with a significant dose response across units of the ISR in African Americans (P < 0.0001). Allelic variation in the CTLA‐4 gene promoter (−1661A/G) significantly modified the association between SLE and EBV‐IgA (P = 0.03), with a stronger association among those with the −1661AA genotype.These findings suggest that repeated or reactivated EBV infection, which results in increased EBV‐IgA seroprevalence and higher IgG antibody titers, may be associated with SLE, and that the CTLA‐4 genotype influences immune responsiveness to EBV in SLE patients. The observed patterns of effect modification by race, age, and CTLA‐4 genotype should be examined in other studies and may help frame new hypotheses regarding the role of EBV in SLE etiology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPSTEIN-Barr virus
KW - HERPESVIRUSES
KW - SYSTEMIC lupus erythematosus
KW - T cells
KW - DISEASES -- Causes & theories of causation
KW - AFRICAN Americans
N1 - Accession Number: 20685913; Christine G. Parks 1 Glinda S. Cooper 2 Lori L. Hudson 3 Mary Anne Dooley 4 Edward L. Treadwell 5 E. W. St.Clair 6 Gary S. Gilkeson 3 Janardan P. Pandey 3; Affiliation: 1: National Institute of Environmental Health Sciences, Durham, North Carolina, and National Institute for Occupational Safety and Health Sciences, Morgantown, West Virginia 2: National Institute of Environmental Health Sciences, Durham, North Carolina 3: Medical University of South Carolina, Charleston 4: University of North Carolina Medical School, Chapel Hill 5: East Carolina University School of Medicine, Greenville, North Carolina 6: Duke University Medical Center, Durham, North Carolina; Source Info: Apr2005, Vol. 52 Issue 4, p1148; Subject Term: EPSTEIN-Barr virus; Subject Term: HERPESVIRUSES; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: T cells; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: AFRICAN Americans; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Wu, Yuh-Shen
AU - Fu, Peter Pi-Cheng
AU - Chang, Cheng-Nan
AU - Chen, Ming-Hsiang
AU - Ho, Tse-Tsung
AU - Huang, Shih-Han
AU - Rau, Jui-Yeh
T1 - Metallic elements study of fine and coarse particulates using a versatile air pollutant system at a traffic sampling site
JO - Atmospheric Research
JF - Atmospheric Research
Y1 - 2005/04//
VL - 75
IS - 1/2
M3 - Article
SP - 1
EP - 14
SN - 01698095
AB - Abstract: Daytime and nighttime period sampling programs were carried out by a versatile air pollutant system (VAPS) to collect the fine (PM2.5) and coarse (PM2.5–10) particulates simultaneously at a traffic sampling site in front of Hungkuang University during August to October 2003. Chemical analyses of metallic elements were accomplished by a flame atomic absorption spectrophotometer coupled with hollow cathode lamps. Statistical methods, such as correlation coefficients and principal component analysis (PCA), were used to compare chemical components and to find the possible emission sources at this traffic sampling site. The variations of metallic element concentrations in fine and coarse particulates during daytime and nighttime were also discussed in this study. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYTICAL chemistry
KW - SPECTROPHOTOMETERS
KW - SPECTRORADIOMETER
KW - LIGHT sources
KW - Coarse particulate
KW - Fine particulate
KW - Traffic
KW - Versatile air pollutant system
N1 - Accession Number: 17545485; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hk.edu.tw Wu, Yuh-Shen 1 Fu, Peter Pi-Cheng 2 Chang, Cheng-Nan 3 Chen, Ming-Hsiang 3 Ho, Tse-Tsung 3 Huang, Shih-Han 1 Rau, Jui-Yeh 1; Affiliation: 1: Air Toxic and Environmental Analysis Laboratory, Hungkuang University, Sha-Lu, Taichung, ROC 433, Taiwan 2: Division of Biochemical Toxicology, National Center for Toxicological Research Jefferson, Arkansas 72079, U.S.A. 3: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan; Source Info: Apr2005, Vol. 75 Issue 1/2, p1; Subject Term: ANALYTICAL chemistry; Subject Term: SPECTROPHOTOMETERS; Subject Term: SPECTRORADIOMETER; Subject Term: LIGHT sources; Author-Supplied Keyword: Coarse particulate; Author-Supplied Keyword: Fine particulate; Author-Supplied Keyword: Traffic; Author-Supplied Keyword: Versatile air pollutant system; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.atmosres.2004.10.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17545485&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106493931
T1 - Commentary. 2005: the year of the healthy child.
AU - Carmona RH
Y1 - 2005/04//2005 Apr-May
N1 - Accession Number: 106493931. Language: English. Entry Date: 20050805. Revision Date: 20150711. Publication Type: Journal Article; anecdote; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9708553.
KW - Child Health
KW - Abnormalities -- Prevention and Control
KW - Air Pollution, Indoor -- Prevention and Control
KW - California
KW - Child
KW - Child Abuse -- Prevention and Control
KW - Congresses and Conferences -- California
KW - Female
KW - Mental Health
KW - Nutrition
KW - Pregnancy
KW - Prenatal Care -- Utilization
KW - Preventive Health Care
KW - Smoking -- Prevention and Control
KW - United States
KW - Wounds and Injuries -- Prevention and Control
KW - Pediatric Obesity -- Prevention and Control
SP - 107
EP - 111
JO - AWHONN Lifelines
JF - AWHONN Lifelines
JA - AWHONN LIFELINES
VL - 9
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1091-5923
AD - United States Surgeon General, US Department of Health and Human Services
U2 - PMID: 15926266.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106493931&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zheng, Xue
AU - Zhang, Yadong
AU - Chen, Yu-quan
AU - Castranova, Vince
AU - Shi, Xianglin
AU - Chen, Fei
T1 - Inhibition of NF-κB stabilizes gadd45α mRNA
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/04//
VL - 329
IS - 1
M3 - Article
SP - 95
EP - 99
SN - 0006291X
AB - Abstract: Growth arrest- and DNA damage-inducible protein α (gadd45α) is an important regulator for cell cycle, genomic stability, and cell apoptosis. In the present report, we demonstrated that NF-κB inhibition due to Ikkβ deficiency enhanced the stability of gadd45α mNRA. Using embryo fibroblast cells derived from wild type (wt) or Ikkβ gene knockout (Ikkβ−/−) mice, reverse transcription-polymerase chain reaction revealed a three- to fourfold increase of gadd45α mRNA in Ikkβ−/− cells compared with wt cells. The deficiency in Ikkβ substantially decreased basal NF-κB activity and increased accumulation of reactive oxygen species (ROS). However, such deficiency had no effect on the basal expression or activity of Akt, FoxO3a, p53, and c-myc that regulate the transcription of gadd45α gene positively or negatively. Analysis of gadd45α mRNA stability showed a ROS-dependent increase in the half-life of gadd45α mRNA in Ikkβ−/− cells. Immunoprecipitation experiments indicated an increased binding of a RNA stabilizing protein, nucleolin, to gadd45α mRNA in Ikkβ−/− cells. The binding of nucleolin to gadd45α mRNA could be prevented by the antioxidant, N-acetyl-cysteine. Thus, these data are the first to suggest that inhibition of Ikkβ-NF-κB signaling up-regulates the expression of gadd45α mNRA through a post-transcriptional, rather than a transcriptional, mechanism. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESSENGER RNA
KW - NUCLEIC acids
KW - DNA damage
KW - BIOCHEMICAL genetics
KW - DNA polymerases
KW - Gadd45α
KW - Ikkβ
KW - mRNA stability
KW - NF-κB
KW - Nucleolin
N1 - Accession Number: 16512716; Zheng, Xue 1,2 Zhang, Yadong 1 Chen, Yu-quan 2 Castranova, Vince 3 Shi, Xianglin 1,3 Chen, Fei 3; Email Address: LFD3@cdc.gov; Affiliation: 1: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, PR China 2: College of Life Science, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, Shaanxi, China 3: The Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Apr2005, Vol. 329 Issue 1, p95; Subject Term: MESSENGER RNA; Subject Term: NUCLEIC acids; Subject Term: DNA damage; Subject Term: BIOCHEMICAL genetics; Subject Term: DNA polymerases; Author-Supplied Keyword: Gadd45α; Author-Supplied Keyword: Ikkβ; Author-Supplied Keyword: mRNA stability; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: Nucleolin; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.01.105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16512716&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Araujo, R.P.
AU - Petricoin, E.F.
AU - Liotta, L.A.
T1 - A mathematical model of combination therapy using the EGFR signaling network
JO - Biosystems
JF - Biosystems
Y1 - 2005/04//
VL - 80
IS - 1
M3 - Article
SP - 57
EP - 69
SN - 03032647
AB - Abstract: An increasing awareness of the significance of abnormal signal transduction in tumors and the concomitant development of target-based drugs to selectively modulate aberrantly-activated signaling pathways has given rise to a variety of promising new strategies in cancer treatment. This paper uses mathematical modeling to investigate a novel type of combination therapy in which multiple nodes in a signaling cascade are targeted simultaneously with selective inhibitors, pursuing the hypothesis that such an approach may induce the desired signal attenuation with lower doses of the necessary agents than when one node is targeted in isolation. A mathematical model is presented which builds upon previous theoretical work on EGFR signaling, simulating the effect of administering multiple kinase inhibitors in various combinations. The model demonstrates that attenuation of biochemical signals is significantly enhanced when multiple upstream processes are inhibited, in comparison with the inhibition of a single upstream process. Moreover, this enhanced attenuation is most pronounced in signals downstream of serially-connected target points. In addition, the inhibition of serially-connected processes appears to have a supra-additive (synergistic) effect on the attenuation of downstream signals, owing to the highly non-linear relationships between network parameters and signals. [Copyright &y& Elsevier]
AB - Copyright of Biosystems is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - MICROBIAL genetics
KW - MATHEMATICAL models
KW - DRUGS
KW - Cancer treatment
KW - Combination therapy
KW - EGFR network
KW - Kinase inhibitors
KW - Signal transduction
N1 - Accession Number: 17437564; Araujo, R.P. 1; Email Address: araujor@mail.nih.gov Petricoin, E.F. 2 Liotta, L.A. 1; Affiliation: 1: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, NCI/NIH, 8800 Rockville Pike, Building 29A, HFM 710, Bethesda, MD 20892, USA 2: FDA-NCI Clinical Proteomics Program, Office of Cell and Gene Therapies, Center for Biologic Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2005, Vol. 80 Issue 1, p57; Subject Term: CANCER treatment; Subject Term: MICROBIAL genetics; Subject Term: MATHEMATICAL models; Subject Term: DRUGS; Author-Supplied Keyword: Cancer treatment; Author-Supplied Keyword: Combination therapy; Author-Supplied Keyword: EGFR network; Author-Supplied Keyword: Kinase inhibitors; Author-Supplied Keyword: Signal transduction; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.biosystems.2004.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17437564&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Wareham, D. W.
AU - Wilks, M.
AU - Ahmed, D.
AU - Brazier, J. S.
AU - Millar, M.
T1 - Anaerobic Sepsis Due to Multidrug-Resistant Bacteroides fragilis: Microbiological Cure and Clinical Response with Linezolid Therapy.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/04//4/1/2005
VL - 40
IS - 7
M3 - Report
SP - e67
EP - e68
SN - 10584838
AB - We describe the first reported case of anaerobic sepsis due to Bacteroides fragilis with simultaneous resistance to metronidazole, β-lactams, β-lactam/β-lactamase inhibitors, carbapenems, macrolides, and tetracyclines. Microbiological cure and clinical improvement was achieved with linezolid therapy, an agent that may be useful for the treatment of multidrug-resistant anaerobic infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Anti-infective agents
KW - Bacterial diseases
KW - Bacteroides
KW - Antiparasitic agents
KW - Metronidazole
N1 - Accession Number: 16400561; Wareham, D. W. 1,2; Email Address: d.w.wareham@qmul.ac.uk; Wilks, M. 2; Ahmed, D. 1; Brazier, J. S. 3; Millar, M. 1,2; Affiliations: 1: Department of Microbiology, Barts & London NHS Trust.; 2: Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary's School of Medicine and Dentistry, University of London, London.; 3: Anaerobe Reference Laboratory, National Public Health Service Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom.; Issue Info: 4/1/2005, Vol. 40 Issue 7, pe67; Thesaurus Term: Antibacterial agents; Thesaurus Term: Anti-infective agents; Thesaurus Term: Bacterial diseases; Subject Term: Bacteroides; Subject Term: Antiparasitic agents; Subject Term: Metronidazole; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 1p; Document Type: Report
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16400561&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tomkinson, A.
AU - Phillips, P.
AU - Scott, J.B.
AU - Harrison, W.
AU - De Martin, S.
AU - Backhouse, S.S.
AU - Temple, M.
T1 - A laboratory and clinical evaluation of single-use instruments for tonsil and adenoid surgery.
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
Y1 - 2005/04//
VL - 30
IS - 2
M3 - Article
SP - 135
EP - 142
PB - Wiley-Blackwell
SN - 17494478
AB - Clin. Otolaryngol. 2005, 30, 135–142 To compare the quality and consistency of single-use adenotonsillectomy instruments available in the UK with reusable instruments and examine their performance in a clinical setting. A laboratory assessment of each reusable instrument created a detailed specification for the respective single-use equivalent. A surveillance system monitored the performance of a selected set of specified single-use instruments. Single-use instruments were withdrawn shortly after their introduction in 2001. Persisting concerns from the Spongiform Encephalopathy Advisory Committee led to an investigation into the feasibility of continuing to use such instruments. The numbers of instruments from each set judged as unacceptable or as good as the original. The number and cause of instrument failure during clinical surveillance. Between 40% and 93% of the instruments on each set were as good as the original and between 0% and 40% of the instruments were unacceptable from six sets of steel and one set of polymer instruments. 4151 procedures were monitored between 1 February 2003 and 31 March 2004 using a total of 41 376 instruments. Problems were reported with 335 (0.8%) instruments, 46% attributable to instrument design, 14% to poor design control and 13% to instruments escaping quality control systems. Following correction of the faults, between 1 January 2004 and 31 March 2004 the problem rate fell to 0.4%. High quality single-use instruments for tonsil and adenoid surgery are available in the UK. Some companies offered inferior instruments not fit for their purpose. The procurement, introduction and subsequent clinical approval of single-use instruments requires a radically different approach to that currently applied to the purchase of reusable surgical equipment. Careful monitoring of their introduction is essential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Otolaryngology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - TONSILLECTOMY
KW - ADENOIDS -- Surgery
KW - SURGICAL instruments & apparatus
KW - GREAT Britain
N1 - Accession Number: 16719662; Tomkinson, A. 1; Email Address: alun.tomkinson@cardiffandvale.wales.nhs.uk Phillips, P. 2 Scott, J.B. 3 Harrison, W. 4 De Martin, S. 5 Backhouse, S.S. 1 Temple, M. 5; Affiliation: 1: Department of Otolaryngology, Head and Neck Surgery, University Hospital Wales, Cardiff 2: Surgical Material Testing Laboratory (SMTL), Princess of Wales Hospital, Bridgend, South Wales 3: Welsh Health Supplies, Bevan House, Cardiff, UK 4: Communicable Disease Surveillance Centre, Abton House, Cardiff 5: National Public Health Service for Wales, Temple of Peace and Health, Cardiff; Source Info: Apr2005, Vol. 30 Issue 2, p135; Subject Term: MEDICAL equipment; Subject Term: TONSILLECTOMY; Subject Term: ADENOIDS -- Surgery; Subject Term: SURGICAL instruments & apparatus; Subject Term: GREAT Britain; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1365-2273.2005.01011.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16719662&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106323277
T1 - Variation in establishing a diagnosis of obesity in children.
AU - Mabry IR
AU - Clark SJ
AU - Kemper A
AU - Fraser K
AU - Kileny S
AU - Cabana MD
Y1 - 2005/04//
N1 - Accession Number: 106323277. Language: English. Entry Date: 20060825. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0372606.
KW - Medical Practice
KW - Pediatric Obesity -- Diagnosis
KW - Pediatricians
KW - Adolescence
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Counseling
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Documentation
KW - Female
KW - Human
KW - Logistic Regression
KW - Male
KW - Medical Records
KW - Michigan
KW - Multivariate Analysis
KW - Pediatric Obesity -- Therapy
KW - Practice Guidelines
KW - Random Sample
KW - Sex Factors
SP - 221
EP - 227
JO - Clinical Pediatrics
JF - Clinical Pediatrics
JA - CLIN PEDIATR
VL - 44
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Consensus guidelines provide recommendations for the diagnosis and management of obesity. We conducted a medical record review of children initially diagnosed with obesity at a general pediatrics visit. The diagnosis was made most often at health maintenance visits (46%). Body mass index was documented in 5% of initial visits; 74% had documentation of obesity-related history; 64% had documentation of counseling. In multivariate analysis, male patients were more likely to have diet history documentation; female patients were more likely to have weight loss program referrals. Future research should assess pediatricians' perceptions about obesity to better understand clinical practice patterns.
SN - 0009-9228
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Suite 6105, Rockville, MD 20850
U2 - PMID: 15821846.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106323277&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Russek-Cohen, Estelle
AU - Martinez, Marilyn N.
AU - Nevius, Anna B.
T1 - A SAS/IML program for simulating pharmacokinetic data
JO - Computer Methods & Programs in Biomedicine
JF - Computer Methods & Programs in Biomedicine
Y1 - 2005/04//
VL - 78
IS - 1
M3 - Article
SP - 39
EP - 60
SN - 01692607
AB - Summary: Data simulation can be an invaluable tool for optimizing the design of bioequivalence trials. It can be particularly useful when exploring alternative approaches for assessing product comparability especially in the context of encountering various complex experimental situations that can occur in veterinary medicine. With this in mind, we designed a novel SAS/IML program to generate pharmacokinetic datasets that reflect the various kinetic, population, and study design characteristics that complicate the bioequivalence evaluation of animal health products. Developing this simulation program within SAS provides an opportunity to utilize the statistical capabilities of this software platform. [Copyright &y& Elsevier]
AB - Copyright of Computer Methods & Programs in Biomedicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
KW - PHARMACOLOGY
KW - MEDICAL care
KW - Bioequivalence
KW - Monte Carlo simulation
KW - Population kinetics
KW - SAS
KW - Veterinary pharmacokinetics
N1 - Accession Number: 16769550; Russek-Cohen, Estelle 1; Email Address: erussek@umd.edu Martinez, Marilyn N. 2; Email Address: mmartin1@cvm.fda.gov Nevius, Anna B. 2; Email Address: anevius@cvm.fda.gov; Affiliation: 1: Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA 2: Center for Veterinary Medicine, US Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Apr2005, Vol. 78 Issue 1, p39; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Subject Term: PHARMACOLOGY; Subject Term: MEDICAL care; Author-Supplied Keyword: Bioequivalence; Author-Supplied Keyword: Monte Carlo simulation; Author-Supplied Keyword: Population kinetics; Author-Supplied Keyword: SAS; Author-Supplied Keyword: Veterinary pharmacokinetics; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.cmpb.2004.10.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16769550&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gardner, William
AU - Lidz, Charles W.
AU - Hartwig, Kathryn C.
T1 - Authors' reports about research integrity problems in clinical trials
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
Y1 - 2005/04//
VL - 26
IS - 2
M3 - Article
SP - 244
EP - 251
SN - 15517144
AB - Abstract: Background: There is little information about the prevalence of research integrity problems in the scientific literature. We sought to determine how frequently authors of published pharmaceutical clinical trials reported fabrication of data or misrepresentation of research. Methods: We conducted a mail survey of 549 authors who had published reports of pharmaceutical clinical trials from 1998 to 2001 that appeared in the Cochrane Database of Systematic Reviews. We asked authors about fabricated data or misrepresentations of research in three contexts: the target study (the report from which their name was obtained), another study they had participated in, or a study that they personally knew about. Results: We received replies from 64% of authors with valid addresses. Two authors (1%) reported that the target article misrepresented the research. Almost 5% reported fabrication or misrepresentation in a study they had participated in the last 10 years, and 17% of authors personally know about a case of fabrication or misrepresentation in the last 10 years from a source other than published accounts of research misconduct. Conclusions: Fraud and misrepresentation in clinical trials appear to be rare on a per-published report basis. However, they occur sufficiently frequently that scientists have a significant chance of participating in a project affected by fraud or misrepresentation during their research careers. These rates of exposure justify vigorous efforts to prevent research misconduct. [Copyright &y& Elsevier]
AB - Copyright of Contemporary Clinical Trials is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - DRUGS
KW - SCIENTISTS
KW - FRAUD
KW - Clinical trials
KW - Research ethics
KW - Research misconduct
N1 - Accession Number: 17664879; Gardner, William 1; Email Address: gardnerw@pediatrics.ohio-state.edu Lidz, Charles W. 2 Hartwig, Kathryn C. 3; Affiliation: 1: Department of Pediatrics and Children's Research Institute, Ohio State University, Columbus, OH, USA 2: Center for Mental Health Services Research, University of Massachusetts School of Medicine, Worcester, MA, USA 3: Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA; Source Info: Apr2005, Vol. 26 Issue 2, p244; Subject Term: CLINICAL trials; Subject Term: DRUGS; Subject Term: SCIENTISTS; Subject Term: FRAUD; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Research ethics; Author-Supplied Keyword: Research misconduct; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.cct.2004.11.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17664879&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pearl Toy
AU - Mark A Popovsky
AU - Edward Abraham
AU - Daniel R Ambruso
AU - Leslie G Holness
AU - Patricia M Kopko
AU - Janice G McFarland
AU - Avery B Nathens
AU - Christopher C Silliman
AU - David Stroncek
T1 - Transfusion-related acute lung injury: Definition and review.
JO - Critical Care Medicine
JF - Critical Care Medicine
Y1 - 2005/04//
VL - 33
IS - 4
M3 - Article
SP - 721
EP - 726
SN - 00903493
AB - BACKGROUND:: Transfusion-related acute lung injury (TRALI) is now the leading cause of transfusion-associated mortality, even though it is probably still underdiagnosed and underreported. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE ACTION:: The National Heart, Lung, and Blood Institute convened a working group to identify areas of research needed in TRALI. The working group identified the immediate need for a common definition and thus developed the clinical definition in this report. MAJOR CONCEPTS IN THE DEFINITION:: The major concept is that TRALI is defined as new acute lung injury occurring during or within 6 hrs after a transfusion, with a clear temporal relationship to the transfusion. Also, another important concept is that acute lung injury temporally associated with multiple transfusions can be TRALI, because each unit of blood or blood component can carry one or more of the possible causative agents: antileukocyte antibody, biologically active substances, and other yet unidentified agents. RECOMMENDATION:: Using the definition in this report, clinicians can diagnose and report TRALI cases to the blood bank; importantly, researchers can use this definition to determine incidence, pathophysiology, and strategies to prevent this leading cause of transfusion-associated mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD transfusion
KW - MORTALITY
KW - MEDICAL personnel
KW - PATHOLOGICAL physiology
N1 - Accession Number: 18499040; Pearl Toy 1 Mark A Popovsky Edward Abraham Daniel R Ambruso Leslie G Holness Patricia M Kopko Janice G McFarland Avery B Nathens Christopher C Silliman David Stroncek; Affiliation: 1: Professor of Laboratory Medicine, School of Medicine, University of CaliforniaSan Francisco, San Francisco, CA (PT); Vice President and Corporate Medical Director, Haemonetics Corporation, Braintree, MA, and Associate Clinical Professor, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA (MAP); Vice Chair, Department of Medicine, University of Colorado School of Medicine, Health Sciences Center, Denver, CO (EA); Professor of Pediatrics, Associate Professor of Pathology (DRA), Associate Professor of Pediatrics and Surgery (CCS), University of Colorado School of Medicine, Associate Medical Director, Bonfils Blood Center, Denver, CO; Medical Officer, Office of Blood Research and Review, Division of Blood Applications, Center for Biologics Evaluation and Research, U.S; Source Info: Apr2005, Vol. 33 Issue 4, p721; Subject Term: BLOOD transfusion; Subject Term: MORTALITY; Subject Term: MEDICAL personnel; Subject Term: PATHOLOGICAL physiology; Number of Pages: 6p; Document Type: Article
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DB - aph
ER -
TY - JOUR
ID - 106016395
T1 - Administration of first hospital antibiotics for community-acquired pneumonia: does timeliness affect outcomes?
AU - Houck PM
AU - Bratzler DW
Y1 - 2005/04//
N1 - Accession Number: 106016395. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8809878.
KW - Antibiotics -- Administration and Dosage
KW - Community-Acquired Infections -- Drug Therapy
KW - Pneumonia, Bacterial -- Drug Therapy
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Antibiotics -- Therapeutic Use
KW - Community-Acquired Infections -- Mortality
KW - Drug Administration Schedule
KW - Inpatients
KW - Middle Age
KW - Pneumonia, Bacterial -- Mortality
KW - Treatment Outcomes
KW - United States
SP - 151
EP - 156
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
JA - CURR OPIN INFECT DIS
VL - 18
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE OF REVIEW: Associations between processes of care for hospitalized community-acquired pneumonia patients and clinical outcomes are important because of the high incidence of such admissions and substantial related mortality. Several studies have examined these associations. RECENT FINDINGS: Large retrospective studies of older patients have demonstrated associations between time to first dose as short as 4 h and length of stay and mortality during and after hospitalization. Results of smaller studies have been less consistent. The association appears to be strongest among older patients who have not received antibiotics prior to arrival at the hospital. SUMMARY: A significant and causal relationship appears to exist between antibiotic timing and improved outcomes, especially among older patients. Even modest improvements in timeliness of antibiotic administration could impact a substantial number of lives because of the high incidence of community-acquired pneumonia hospitalization.
SN - 0951-7375
AD - U.S. Public Health Service, Region 10; 2201 Sixth Avenue MS 20, Seattle, WA 98121, USA
U2 - PMID: 15735420.
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DB - rzh
ER -
TY - JOUR
AU - Park, Yeon-Joon
AU - Park, Sun Young
AU - Oh, Eun-Jee
AU - Park, Jung-Jun
AU - Lee, Kyo-Young
AU - Woo, Gun-Jo
AU - Lee, Kyungwon
T1 - Occurrence of extended-spectrum β-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens in Korea and investigation of screening criteria
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2005/04//
VL - 51
IS - 4
M3 - Article
SP - 265
EP - 269
SN - 07328893
AB - Abstract: We assessed the occurrence and screening criterion for extended-spectrum β-lactamases (ESBLs) among AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens. The 413 isolates (158 E. cloacae, 126 C. freundii, and 129 S. marcescens) isolated from 11 clinical laboratories in Korea were investigated. ESBL production was confirmed by double-disk synergy test and inhibitor-potentiated diffusion test using ceftazidime (CAZ), cefotaxime (CTX), aztreonam (AZT), and cefepime (FEP) with or without clavulanic acid. One hundred seven isolates (25.9%) were as ESBL producers. Of them, resistance was transferred by conjugation in 82 isolates. In transconjugants, structural genes for CTX-M (53.7%), TEM (46.3%), SHV (29.3%) were found. To evaluate the ESBL screening minimum inhibitory concentration (MIC) criteria, MICs for cefuroxime, CAZ, CTX, AZT, and FEP were determined and cutoff value was selected using receiver operator characteristic curve. The FEP MIC ≥ 1 μg/mL had the highest sensitivity (95.3%), specificity (82.7%), and positive (65.8%) and negative predictive values (98.3%). [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMOSOMES
KW - ENTEROBACTER cloacae
KW - SERRATIA marcescens
KW - SERRATIA
KW - Citrobacter freundii
KW - Enterobacter cloacae
KW - Extended-spectrum β-lactamase
KW - Screening criteria
KW - Serratia marcescens
N1 - Accession Number: 16873475; Park, Yeon-Joon 1; Email Address: yjpk@catholic.ac.kr Park, Sun Young 1 Oh, Eun-Jee 1 Park, Jung-Jun 1 Lee, Kyo-Young 1 Woo, Gun-Jo 2 Lee, Kyungwon 3; Affiliation: 1: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St. Mary's Hospital, Seoul 137-040, Korea 2: Korea Food and Drug Administration, Seoul 137-040, Korea 3: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 137-040, Korea; Source Info: Apr2005, Vol. 51 Issue 4, p265; Subject Term: CHROMOSOMES; Subject Term: ENTEROBACTER cloacae; Subject Term: SERRATIA marcescens; Subject Term: SERRATIA; Author-Supplied Keyword: Citrobacter freundii; Author-Supplied Keyword: Enterobacter cloacae; Author-Supplied Keyword: Extended-spectrum β-lactamase; Author-Supplied Keyword: Screening criteria; Author-Supplied Keyword: Serratia marcescens; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2004.11.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106536395
T1 - The National Response Plan: Health and Human Services the lead for emergency support function #8.
AU - Couig MP
AU - Martinelli A
AU - Lavin RP
Y1 - 2005/04//2005 Apr-Jun
N1 - Accession Number: 106536395. Language: English. Entry Date: 20051111. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101155781.
KW - Disaster Planning
KW - Emergency Care
KW - Government Agencies
KW - Legislation
KW - Military Personnel
KW - Nursing Role
KW - United States
SP - 34
EP - 40
JO - Disaster Management & Response
JF - Disaster Management & Response
JA - DISASTER MANAGE RESPONSE
VL - 3
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - On January 6, 2005, the National Response Plan (NRP) was introduced to standardize a national approach for responding to natural or man-made threats. The underlying structure for the NRP is the National Incident Management System, which establishes standardized training, organization, and communications procedures that can be used by multiple jurisdictions to interact in a disaster. The NRP clearly identifies authority and leader-ship responsibilities. The NRP organizes the government's emergency operations into 15 emergency support functions, of which Emergency Support Function #8 pertains to public health and medical services. The United States Public Health Service (PHS) Commissioned Corps is one of the seven uniformed services of the United States, and PHS officers can be deployed to help meet urgent public health needs when traditional mechanisms and resources are overwhelmed. The role of PHS nurses is presented.
SN - 1540-2487
AD - Assistant Surgeon General, Chief Nurse Officer, United States Public Health Service, Room 6A-55, 5600 Fishers Lane, Rockville, MD 20857
U2 - PMID: 15829907.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106536398
T1 - Medical Reserve Corps: strengthening public health and improving preparedness.
AU - Hoard ML
AU - Tosatto RJ
Y1 - 2005/04//2005 Apr-Jun
N1 - Accession Number: 106536398. Language: English. Entry Date: 20051111. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Allied Health; Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101155781.
KW - Disaster Planning
KW - Volunteer Workers
KW - Government Agencies
KW - United States
SP - 48
EP - 52
JO - Disaster Management & Response
JF - Disaster Management & Response
JA - DISASTER MANAGE RESPONSE
VL - 3
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - Across the United States, millions of Americans volunteer their time and efforts to improve the social fabric of their communities. Inevitably, some of these volunteers will be medical and public health professionals. However, because of the complexities of the health field, including concerns about credentialing, training and legal protections, many of these persons have not been able to volunteer in their professional capacities. The terrorist events of 2001 showed that not only would individuals with medical and public health expertise want to volunteer, but that their help could be very much needed in future mass catastrophic events. The Medical Reserve Corps Program was created as a national system of community-based units to promote the local identification, recruitment, training, and activation of volunteers, especially those with medical and public health backgrounds. These Medical Reserve Corps units supplement the existing public health and emergency response entities in the community.
SN - 1540-2487
AD - Program Officer for Outreach, United States Public Health Service, Office of the US Surgeon General, Medical Reserve Corps Program, Rm 18C-14 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; mhoard@osophs.dhhs.gov
U2 - PMID: 15829909.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - de Rosa, Maria I.
T1 - NIOSH Study Documents a Decade of Equipment Fires.
JO - Engineering & Mining Journal (00958948)
JF - Engineering & Mining Journal (00958948)
Y1 - 2005/04//
VL - 206
IS - 3
M3 - Article
SP - 40
EP - 44
PB - Mining Media Inc.
SN - 00958948
AB - This article focuses on a study in which the U.S. National Institute for Occupational Safety and Health analyzed equipment fires for all types of underground mines and mills in the U.S. during 1990-1999. A total of 24 equipment fires occurred in underground metal/nonmetal and stone mines during 1990-1999; seven injuries were caused by four of those fires. There were 49 equipment fires at surface metal/nonmetal mines during 1990-1999; 35 injuries and one fatality were caused by 24 of those fires. In both cases, the most common ignition source was hydraulic fluid /fuel sprayed onto equipment hot surfaces.
KW - Fires
KW - Mines & mineral resources
KW - Work-related injuries
KW - Disasters
KW - Hydraulic fluids
KW - United States
N1 - Accession Number: 17013282; de Rosa, Maria I. 1; Email Address: MGD8@cdc.gov; Affiliations: 1: Industrial hygienist, Pittsburgh Research Laboratory, National institute for Occupational Safety and Health.; Issue Info: Apr2005, Vol. 206 Issue 3, p40; Thesaurus Term: Fires; Thesaurus Term: Mines & mineral resources; Subject Term: Work-related injuries; Subject Term: Disasters; Subject Term: Hydraulic fluids; Subject: United States; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 3p; Document Type: Article
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ER -
TY - JOUR
AU - Cox-Ganser, Jean M.
AU - White, Sandra K.
AU - Jones, Rebecca
AU - Hilsbos, Ken
AU - Storey, Eileen
AU - Enright, Paul L.
AU - Rao, Carol Y.
AU - Kreiss, Kathleen
T1 - Respiratory Morbidity in Office Workers in a Water-Damaged Building.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/04//
VL - 113
IS - 4
M3 - Article
SP - 485
EP - 490
PB - Superintendent of Documents
SN - 00916765
AB - We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, lifetime asthma, and current asthma, 3.3 for adult-onset asthma, and 3.4 for symptoms improving away from work (p < 0.05). Two-thirds (66/103) of the adult-onset asthma arose after occupancy, with an incidence rate of 1.9/1,000 person-years before building occupancy and 14.5/1,000 person-years after building occupancy. We conducted a second survey on 140 respiratory cases, 63 subjects with fewer symptoms, and 44 comparison subjects. Health-related quality of life decreased with increasing severity of respiratory symptoms and in those with work-related symptoms. Symptom status was not associated with job satisfaction or how often jobs required hard work. Respiratory health problems accounted for one-third of sick leave, and respiratory cases with work-related symptoms had more respiratory sick days than those without work-related symptoms (9.4 vs. 2.4 days/year; p < 0.01). Abnormal lung function and/or breathing medication use was found in 67% of respiratory cases, in 38% of participants with fewer symptoms, and in 11% of the comparison group (p < 0.01), with similar results in never-smokers. Postoccupancy-onset asthma was associated with less atopy than preoccupancy-onset asthma. Occupancy of the water-damaged building was associated with onset and exacerbation of respiratory conditions, confirmed by objective medical tests. The morbidity and lost work time burdened both employees and employers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Office buildings
KW - Asthma
KW - Respiratory diseases
KW - Clerks
KW - Obstructive lung diseases
KW - Wheeze
KW - Job satisfaction
KW - Symptoms
KW - building-related symptoms
KW - hypersensitivity pneumonitis
KW - indoor environment
KW - occupational asthma
KW - office workers
KW - quality of life
KW - sarcoidosis
KW - sick leave
N1 - Accession Number: 16660158; Cox-Ganser, Jean M. 1; Email Address: jjc8@cdc.gov; White, Sandra K. 1; Jones, Rebecca 1; Hilsbos, Ken 1; Storey, Eileen 2; Enright, Paul L. 1; Rao, Carol Y. 1; Kreiss, Kathleen 1; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: University of Connecticut Health Center, Farmington, Connecticut, USA; Issue Info: Apr2005, Vol. 113 Issue 4, p485; Thesaurus Term: Office buildings; Thesaurus Term: Asthma; Subject Term: Respiratory diseases; Subject Term: Clerks; Subject Term: Obstructive lung diseases; Subject Term: Wheeze; Subject Term: Job satisfaction; Subject Term: Symptoms; Author-Supplied Keyword: building-related symptoms; Author-Supplied Keyword: hypersensitivity pneumonitis; Author-Supplied Keyword: indoor environment; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: office workers; Author-Supplied Keyword: quality of life; Author-Supplied Keyword: sarcoidosis; Author-Supplied Keyword: sick leave; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/chp.7559
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ER -
TY - JOUR
AU - Mischler, Steven E.
AU - Volkwein, Jon C.
T1 - Differential Pressure as a Measure of Particulate Matter Emissions from Diesel Engines.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2005/04//4/1/2005
VL - 39
IS - 7
M3 - Article
SP - 2255
EP - 2261
SN - 0013936X
AB - A diesel particulate matter analyzer capable of direct, real-time measurement of engine exhaust particulate is necessary to effectively institute source control technology currently being used on diesel equipment and to ensure that the control measures are working. To investigate the potential of a differential pressure monitor to measure diesel particulate matter in undiluted exhaust, samples were collected from three different diesel engines-Kubota, Isuzu, and Deutz-running under 12 different RPM and load scenarios. These measurements were compared to elemental carbon concentrations in the sampled exhaust as determined by using the NIOSH 5040 analytical method. Elemental carbon is used as a surrogate measurement for diesel particulate matter. The results of the two data sets were then compared using a linear regression analysis. The coefficient of determination (or R²) was calculated to be 0.98, 0.94, and 0.74 for the Kubota, Deutz, and Isuzu engines, respectively. R7sup2; values of this magnitude indicate that this method can be successful in estimating elemental carbon emissions in the engines tested. In addition, for replicate samples, the coefficient of variation ranged from 7.1% to 10.2% with an average of 8.5%. These data indicate that this method could prove useful to mechanics as they work to maintain engines and DPM control technologies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Emissions (Air pollution)
KW - Emission control
KW - Engines
KW - Internal combustion engines
KW - Diesel motors
N1 - Accession Number: 16721659; Mischler, Steven E. 1; Email Address: smischlr@cdc.gov; Volkwein, Jon C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236.; Issue Info: 4/1/2005, Vol. 39 Issue 7, p2255; Thesaurus Term: Air pollution; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Emission control; Thesaurus Term: Engines; Thesaurus Term: Internal combustion engines; Subject Term: Diesel motors; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; NAICS/Industry Codes: 336310 Motor Vehicle Gasoline Engine and Engine Parts Manufacturing; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Gioia, Carolina A.C.
AU - de Sousa, Adriana B.
AU - Cruz, Simone C.
AU - Junior, Feliciano C.S.
AU - Andrade, Arnaldo F.B.
AU - Sassi, Raul M.
AU - Frasch, Carl E.
AU - Milagres, Lucimar G.
T1 - Effect of a booster dose of serogroup B meningococcal vaccine on antibody response to Neisseria meningitidis in mice vaccinated with different immunization schedules
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2005/04//
VL - 44
IS - 1
M3 - Article
SP - 35
EP - 42
SN - 09288244
AB - Abstract: The generation and maintenance of memory antibody response by different primary immunization schedules with the Cuban-produced outer membrane protein based vaccine was investigated in a murine model. We analyzed the duration of the antibody response (IgG-ELISA and bactericidal titer) and the effect of a booster dose on the antibody response. The IgG avidity index was determined in an attempt to find a marker for memory development. This study also included an analysis of IgG subclasses induced by primary and booster immunization. The specificity of bactericidal antibodies was investigated using local strains of the same serotype/serosubtype (4,7:P1.19,15) as the vaccine strain and mutant strains lacking major outer membrane proteins. A significant recall response was induced by a booster dose given 7 months after a primary series of 2, 3 or 4 doses of vaccine. The primary antibody response showed a positive dose-effect. In contrast, a negative dose-effect was found on the booster bactericidal antibody response. There was a significant increase in IgG1 levels after the fourth and booster doses. Three doses of vaccine were required to induce a significant increase in IgG avidity. Two injections of vaccine induced a significant antibody response to PorA protein, while 4 injections induced a larger range of specificities. [Copyright &y& Elsevier]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - GRAM-negative bacteria
KW - VACCINATION
KW - IMMUNOGLOBULINS
KW - Bactericidal antibody and serological memory
KW - Neisseria meningitidis
KW - Vaccine
N1 - Accession Number: 16769558; Gioia, Carolina A.C. 1,2 de Sousa, Adriana B. 2 Cruz, Simone C. 2 Junior, Feliciano C.S. 2 Andrade, Arnaldo F.B. 2 Sassi, Raul M. 1 Frasch, Carl E. 3 Milagres, Lucimar G. 2; Email Address: lucimar@uerj.br; Affiliation: 1: Fundação Universidade Federal de Rio Grande, Hospital Universitário, Departamento de Patologia/Microbiologia e Imunologia, Rua Osório S/N. CEP: 96200400. Rio Grande, RS, Brasil 2: Universidade do Estado do Rio de Janeiro, Bl. 28 de Setembro, 87, Fundos 3° andar, Disciplina de Microbiologia e Imunologia, CEP: 20551030, Rio de Janeiro, RJ, Brasil 3: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Apr2005, Vol. 44 Issue 1, p35; Subject Term: NEISSERIA meningitidis; Subject Term: GRAM-negative bacteria; Subject Term: VACCINATION; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: Bactericidal antibody and serological memory; Author-Supplied Keyword: Neisseria meningitidis; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.femsim.2004.11.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hwang, C.C.
AU - Edwards, J.C.
T1 - The critical ventilation velocity in tunnel fires—a computer simulation
JO - Fire Safety Journal
JF - Fire Safety Journal
Y1 - 2005/04//
VL - 40
IS - 3
M3 - Article
SP - 213
EP - 244
SN - 03797112
AB - Abstract: In ventilated tunnel fires, smoke and hot combustion products may form a layer near the ceiling and flow in the direction opposite to the ventilation stream. The existence of this reverse stratified flow has an important bearing on fire fighting and evacuation of underground mine roadways, tunnels and building corridors. In the present study, conducted by the National Institute for Occupational Safety and Health, a CFD program (fire dynamics simulator) based on large eddy simulations (LES) is used to model floor-level fires in a ventilated tunnel. Specifically, the critical ventilation velocity that is just sufficient to prevent the formation of a reverse stratified layer is simulated for two tunnels of different size. The computer code is verified by checking the computed velocity profile against experimental measurements. The CFD results show the leveling-off of the critical ventilation velocity as the heat release rate surpasses a certain value. At this critical ventilation, the ceiling temperature above the fire reaches a maximum for both tunnels. The velocity leveling-off can be explained from this observation. An extended correlation of Newman (Combust. Flame 57 (1984) 33) is applied to the temperature profiles obtained by CFD. At the critical ventilation, temperature stratification exists downstream from the fire. The computed critical ventilation velocity shows fair agreement with available experimental data taken from both horizontal and inclined fire tunnels. The CFD simulations indicate that the Froude modeling is an approximation for tunnel fires. The Froude-scaling law does not apply to two geometrically similar fire tunnels. The CFD results are compared with two simple theories of critical ventilation by Kennedy et al. (ASHRAE Trans. Res. 102(2) (1996) 40) and Kunsch (Fire safety J. 37 (2002) 67). [Copyright &y& Elsevier]
AB - Copyright of Fire Safety Journal is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ventilation
KW - Computer simulation
KW - Fire prevention
KW - Air conditioning
KW - Critical ventilation velocity
KW - Froude modeling
KW - Large eddy simulation
KW - Stratified flow
KW - Tunnel Fire
N1 - Accession Number: 17674349; Hwang, C.C.; Email Address: ckh9@cdc.gov; Edwards, J.C. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA 15236-0070, USA; Issue Info: Apr2005, Vol. 40 Issue 3, p213; Thesaurus Term: Ventilation; Thesaurus Term: Computer simulation; Thesaurus Term: Fire prevention; Thesaurus Term: Air conditioning; Author-Supplied Keyword: Critical ventilation velocity; Author-Supplied Keyword: Froude modeling; Author-Supplied Keyword: Large eddy simulation; Author-Supplied Keyword: Stratified flow; Author-Supplied Keyword: Tunnel Fire; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; Number of Pages: 32p; Document Type: Article
L3 - 10.1016/j.firesaf.2004.11.001
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ER -
TY - JOUR
AU - Sprando, Robert L.
AU - Collins, Thomas F.X.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Sapienza, Philip
AU - Ramos-Valle, Moraima
AU - Ruggles, Dennis I.
T1 - Maternal exposure to androstenedione does not induce developmental toxicity in the rat
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/04//
VL - 43
IS - 4
M3 - Article
SP - 505
EP - 513
SN - 02786915
AB - Abstract: Thirty-day old female rats received corn oil or androstenedione (in corn oil) at one of four concentrations (5.0, 10.0, 30.0 or 60.0mg/kg body weight) by gavage for two weeks prior to mating, during the mating period and until gestation day (GD) 19. Caesarean sections were performed on GD 20. No dose related changes were observed in serum androstenedione, estradiol, LH, FSH, testosterone or progesterone. A statistically significant decrease in estrous cycle length was observed in the 60.0mg/kg dose group only. Feed and fluid consumption, mean body weight gain, organ weight and fetal parameters were not affected by androstenedione treatment. At the doses given, androstenedione had no specific effect on the development of individual bones or soft tissues. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RATS
KW - CORN oil
KW - ANDROSTENEDIONE
KW - ESTRUS
KW - TESTOSTERONE
KW - analysis of covariance ( ANCOVA )
KW - analysis of variance ( ANOVA )
KW - Androstenedione
KW - Estrous cycle
KW - Fetus
KW - Rats
N1 - Accession Number: 17411852; Sprando, Robert L.; Email Address: rsprando@cfsan.fda.gov Collins, Thomas F.X. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Sapienza, Philip 1 Ramos-Valle, Moraima 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, USA; Source Info: Apr2005, Vol. 43 Issue 4, p505; Subject Term: RATS; Subject Term: CORN oil; Subject Term: ANDROSTENEDIONE; Subject Term: ESTRUS; Subject Term: TESTOSTERONE; Author-Supplied Keyword: analysis of covariance ( ANCOVA ); Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: Androstenedione; Author-Supplied Keyword: Estrous cycle; Author-Supplied Keyword: Fetus; Author-Supplied Keyword: Rats; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; NAICS/Industry Codes: 311221 Wet Corn Milling; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2004.11.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17411852&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flynn, T.J.
AU - Sapienza, P.P.
AU - Wiesenfeld, P.W.
AU - Ross, I.A.
AU - Sahu, S.
AU - Kim, C.S.
AU - O’Donnell, M.W.
AU - Collins, T.F.X.
AU - Sprando, R.L.
T1 - Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/04//
VL - 43
IS - 4
M3 - Article
SP - 537
EP - 542
SN - 02786915
AB - Abstract: It is unknown whether androstenedione, a steroidal dietary supplement taken to enhance athletic performance, can affect physiological hormone levels by altering liver enzyme activities that metabolize steroid hormones. Altered hormone levels could be especially devastating during pregnancy. Mature female rats were gavaged with 0, 5, 30 or 60mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60mg/kg/day androstenedione. Livers were removed from dams on gestation day 20 and from non-pregnant rats after five weeks’ treatment. Liver microsomes were incubated with 200μM testosterone, and the reaction products were isolated and analyzed by HPLC. In pregnant rats, formation of 6α-, 15β-, 7α-, 16β-, and 2β-hydroxytestosterone was increased significantly vs. control at the highest dose level only. Formation of 6β-hydroxytestosterone increased significantly at both the 30 and 60mg/kg/day dose levels. In non-pregnant rats, 60mg/kg/day androstenedione significantly increased formation of 15β-, 6β-, 16β-, and 2β-hydroxytestosterone. The data suggest that high oral doses of androstenedione can induce some female rat liver cytochromes P450 that metabolize steroid hormones and that the response to androstenedione does not differ between pregnant and non-pregnant female rats. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROSTENEDIONE
KW - STEROID hormones
KW - DIETARY supplements
KW - ENZYMES
KW - LIVER
KW - Androstenedione
KW - Cytochromes P450
KW - Endocrine disruption
KW - Liver
KW - Steroids
N1 - Accession Number: 17411856; Flynn, T.J. 1; Email Address: tflynn@cfsan.fda.gov Sapienza, P.P. 1 Wiesenfeld, P.W. 1 Ross, I.A. 1 Sahu, S. 1 Kim, C.S. 1 O’Donnell, M.W. 2 Collins, T.F.X. 1 Sprando, R.L. 1; Affiliation: 1: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: US FDA, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Apr2005, Vol. 43 Issue 4, p537; Subject Term: ANDROSTENEDIONE; Subject Term: STEROID hormones; Subject Term: DIETARY supplements; Subject Term: ENZYMES; Subject Term: LIVER; Author-Supplied Keyword: Androstenedione; Author-Supplied Keyword: Cytochromes P450; Author-Supplied Keyword: Endocrine disruption; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Steroids; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fct.2004.12.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sprando, Robert L.
AU - Collins, Thomas F.X.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Rorie, James I.
AU - Eppley, Robert M.
AU - Ruggles, Dennis I.
T1 - Characterization of the effect of deoxynivalenol on selected male reproductive endpoints
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/04//
VL - 43
IS - 4
M3 - Article
SP - 623
EP - 635
SN - 02786915
AB - Abstract: The effect of deoxynivalenol (DON) exposure on male reproductive function was assessed in the rat. Male rats were divided into a control group (n =15 rats) and four treatment groups (0.5mg/kg, n =15; 1.0mg/kg, n =15; 2.5mg/kg, n =15; and 5.0mg/kg DON, n =16) and exposed to DON daily for 28 days via gastric intubation. Both body weight gain and the final body weight of animals in the 5.0mg/kg dose group and feed consumption in animals in the 2.5mg/kg and 5.0mg/kg dose groups were significantly reduced compared to controls. Fluid consumption was not affected in any of the treated groups. Epididymal and seminal vesicle weights expressed per gram of body weight and brain weight were significantly reduced, compared to control weights, in animals from the 2.5 and 5.0mg/kg dose groups while prostate weight expressed per gram of brain weight and body weight was significantly lower than controls only in the 5.0mg/kg dose group. A statistically significant, dose-related decrease in homogenization resistant testicular spermatid counts, spermatid numbers, absolute cauda epididymal sperm numbers and cauda epididymal sperm numbers per gram of cauda epididymis was observed in the 5.0mg/kg DON treatment group. Sperm tail abnormalities (broken tails) in the 5.0mg/kg dose group were significantly higher than in the control group. Sperm swimming speed (VSL and VCL) was significantly increased only in the 2.5mg/kg dose group. Serum FSH and LH concentrations were increased in a dose dependent manner across all treated groups while serum testosterone concentrations were decreased in a dose-related manner across all dose groups. An increase in germ cell degeneration, sperm retention and abnormal nuclear morphology was observed in the 2.5mg/kg and 5.0mg/kg dose groups. Treatment related effects included lesions in the non-glandular stomach, thymic lymphoid depletion and splenic hematopoiesis in the 5.0mg/kg treatment group. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REPRODUCTION
KW - RATS
KW - MALES
KW - SPERMATOZOA
KW - GERM cells
KW - Analysis of variance, ANOVA
KW - Computer assisted sperm analysis, CASA
KW - Deoxnivalenol
KW - Mycotoxin
KW - Rat
KW - Sperm motility
KW - Spermatogenesis
KW - Testis
KW - Write once read many, WORM
N1 - Accession Number: 17411867; Sprando, Robert L.; Email Address: rsprando@cfsan.fda.gov Collins, Thomas F.X. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Rorie, James I. 1 Eppley, Robert M. 1 Ruggles, Dennis I. 1; Affiliation: 1: Food and Drug Administration, Developmental and Reproductive Toxicology Branch, Division of Toxicology and Nutritional Product Studies, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708, United States; Source Info: Apr2005, Vol. 43 Issue 4, p623; Subject Term: REPRODUCTION; Subject Term: RATS; Subject Term: MALES; Subject Term: SPERMATOZOA; Subject Term: GERM cells; Author-Supplied Keyword: Analysis of variance, ANOVA; Author-Supplied Keyword: Computer assisted sperm analysis, CASA; Author-Supplied Keyword: Deoxnivalenol; Author-Supplied Keyword: Mycotoxin; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Sperm motility; Author-Supplied Keyword: Spermatogenesis; Author-Supplied Keyword: Testis; Author-Supplied Keyword: Write once read many, WORM; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.fct.2004.12.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17411867&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Schulberg, Myles
AU - Corbett, J. Trent
AU - Plyler, Al
T1 - Letters.
JO - Government Executive
JF - Government Executive
J1 - Government Executive
PY - 2005/04//4/1/2005
Y1 - 2005/04//4/1/2005
VL - 37
IS - 5
M3 - Letter
SP - 8
EP - 8
PB - National Journal Group, Inc.
SN - 00172626
AB - Presents several letters to the editor. Discussion on the U.S. Homeland Security Department; Focus on the U.S. missile defense system's controversial acquisition approach; Discussion on the usage of federal employees to bail out the social security system in 1986.
KW - LETTERS to the editor
KW - NATIONAL security -- United States
KW - SOCIAL security
KW - ROCKETS (Ordnance)
KW - UNITED States -- Officials & employees
KW - UNITED States
N1 - Accession Number: 16816196; Source Information: 4/1/2005, Vol. 37 Issue 5, p8; Subject Term: LETTERS to the editor; Subject Term: NATIONAL security -- United States; Subject Term: SOCIAL security; Subject Term: ROCKETS (Ordnance); Subject Term: UNITED States -- Officials & employees; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 2/3p; ; Document Type: Letter; ; Full Text Word Count: 500;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
TY - GEN
AU - Encinosa, WE;
AU - Bernard, DM;
AU - Steiner, CA;
AU - Chen, CC;
T1 - Use and costs of bariatric surgery and prescription weight-loss medications
CT - Use and costs of bariatric surgery and prescription weight-loss medications
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/04/01/
VL - 24
IS - Apr
SP - 1039
EP - 1046
SN - 02782715
AD - Agency Healthcare Res & Qual, Ctr Delivery Org & Markets, Rockville, MD, USA wencinos@ahrq.gov
N1 - Accession Number: 42-17577; Language: English; References: 26; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Drug Evaluations
N2 - The extent of use of bariatric surgery and weight-loss medications is unknown. Using the Nationwide Inpatient Sample, we estimate that the number of bariatric surgeries grew 400 percent between 1998 and 2002; such surgeries were performed on 0.6 percent of the 11.5 million adults clinically eligible in 2002. Hospital costs for bariatric surgery grew sixfold to $948 million in 2002. The inpatient death rate declined 64 percent. Among employers that covered weight-loss drugs in 2002, less than 2.4 percent of adults clinically eligible for these drugs used them, with average annual spending of $304 per user.
KW - Drug utilization--evaluation;
KW - Anorexics--rational therapy;
KW - Obesity--anorexics;
KW - Costs--anorexics;
KW - Prescriptions--drugs;
KW - Surgery--costs;
KW - Outcomes--economics;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=42-17577&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Bradley, Elizabeth H.
AU - Carlson, Melissa D. A.
AU - Gallo, William T.
AU - Scinto, Jeanne
AU - Campbell, Miriam K.
AU - Krumholz, Harlan M.
AD - Yale U
AD - Yale U
AD - Yale U
AD - Saint Raphael Health Care System, New Haven, CT
AD - Center for Medicare and Medicaid Servicees, US Department of Health and Human Services, Boston
AD - Yale U
T1 - From Adversary to Partner: Have Quality Improvement Organizations Made the Transition?
JO - Health Services Research
JF - Health Services Research
Y1 - 2005/04//
VL - 40
IS - 2
SP - 459
EP - 476
SN - 00179124
N1 - Accession Number: 0776684; Keywords: Medicare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200506
N2 - To describe the perceived impact of the Centers for Medicare and Medicaid Services Quality Improvement Organizations (QIOs) on quality of care for patients hospitalized with acute myocardial infarction, in the context of new efforts to work more collaboratively with hospitals in the pursuit of quality improvement. We interviewed quality management directors concerning their interactions with the QIO interventions, the helpfulness of QIO interventions and the degree to which they helped or hindered their hospital quality efforts, and their recommendations for improving QIO effectiveness. Our study demonstrates that the QIOs have overcome, to some degree, the previously adversarial and punitive roles of Peer Review Organizations with hospitals. The generally positive view among most hospital quality improvement directors concerning the QIO interventions suggests that QIOs are potentially poised to take a leading role in promoting quality of care. However, the full potential of QIOs will likely not be realized until QIOs are able to engender greater engagement from senior hospital administration and physicians.
KW - National Government Expenditures and Health H51
KW - Health: Government Policy; Regulation; Public Health I18
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - GEN
AU - Maluping, R.P.
AU - Lavilla-Pitogo, C.R.
AU - DePaola, A.
AU - Janda, J.M.
AU - Krovacek, K.
AU - Greko, C.
T1 - Antimicrobial susceptibility of Aeromonas spp., Vibrio spp. and Plesiomonas shigelloides isolated in the Philippines and Thailand
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2005/04//
VL - 25
IS - 4
M3 - Letter
SP - 348
EP - 350
SN - 09248579
N1 - Accession Number: 17545938; Maluping, R.P. 1,2; Lavilla-Pitogo, C.R. 3; DePaola, A. 4; Janda, J.M. 5; Krovacek, K. 1; Email Address: karel.krovacek@vmm.slu.se; Greko, C. 6; Affiliations: 1: Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine, SLU, Box 7036, SE-75007 Uppsala, Sweden; 2: Department of Veterinary Paraclinical Sciences, College of Veterinary Medicine, University of the Philippines-Los Banos, 4031 College, Laguna, Philippines; 3: Aquaculture Department, Southeast Asian Fisheries Development Centre, Tigbauan, 5021 Iloilo, Philippines; 4: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration (FDA), Dauphin Island, AL 36528-0158, USA; 5: Microbial Diseases Laboratory, California Department of Health, 850 Marina Bay Parkway, Room E164, Richmond, CA 94804, USA; 6: Department of Antibiotics, National Veterinary Institute (SVA), SE-75189 Uppsala, Sweden; Issue Info: Apr2005, Vol. 25 Issue 4, p348; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.ijantimicag.2005.01.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Newton, Katherine M.
AU - Buist, Diana S.M.
AU - Miglioretti, Diana L.
AU - Beverly, Kevin
AU - Hartsfield, Cynthia L.
AU - Chan, K.Arnold
AU - Andrade, Susan E.
AU - Wei, Feifei
AU - Connelly, Maureen T.
AU - Kessler, Larry
T1 - The Impact of Comorbidities on Hormone Use.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2005/04//
VL - 20
IS - 4
M3 - Article
SP - 350
EP - 356
SN - 08848734
AB - Determine the impact of fracture, coronary disease, and diabetes on changes in rates of discontinuation and initiation of estrogen therapy with (EPT) and without (ET) progestin, before (September 1, 1999 to June 30, 2002, baseline) versus 5 months after (follow-up) release of the Women's Health Initiative EPT trial results (WHI).Observational cohort; 169,586 women 40 to 80 years old from 5 U.S. HMOs.We used pharmacy data to identify ET and EPT users. A woman was a user any month she filled≥1 estrogen prescription and in subsequent months based upon the number of pills/patches dispensed. We used inpatient and outpatient claims to identify fracture January 1, 1999 to June 30, 2002 and pharmacy data to identify disease-based groups of medications for diabetes and cardiovascular disease.EPT/ET prevalence, initiation, and discontinuation rates.Baseline to follow-up EPT and ET prevalence declined 45% and 22%, respectively, with no difference by comorbidity. Follow-up EPT initiation was half the baseline rate irrespective of comorbidity. Compared to baseline, follow-up EPT discontinuation rates increased among women with diabetes (relative risk [RR], 6.9; 95% confidence interval [CI], 5.6 to 8.4), cardiovascular disease (RR, 5.5; 95% CI, 4.9 to 6.2), fracture (RR, 3.8; 95% CI, 2.4 to 5.7), and no comorbidity (RR, 4.4; 95% CI, 3.9 to 4.9). The RRs for follow-up versus baseline EPT discontinuation were higher among women with diabetes (P<.01) and cardiovascular disease (P<.01) versus women without these comorbidities. ET discontinuation rates among these same groups were elevated 2- to 2.8-fold.Diabetes and cardiovascular disease were associated with higher EPT discontinuation rates post-WHI compared to women without comorbidity; comorbidity had little impact on changes in prevalence or initiation of ET/EPT after release of the WHI. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMORBIDITY
KW - WOMEN -- Health
KW - EPIDEMIOLOGY
KW - ESTROGEN
KW - CORONARY heart disease
KW - ENDOCRINE diseases
KW - estrogen
KW - fracture
KW - hormone therapy
KW - menopause
KW - women
N1 - Accession Number: 16807580; Newton, Katherine M. 1,2; Email Address: newton.k@ghc.org Buist, Diana S.M. 1,2 Miglioretti, Diana L. 1,2 Beverly, Kevin 1 Hartsfield, Cynthia L. 3 Chan, K.Arnold 4,5 Andrade, Susan E. 6 Wei, Feifei 7 Connelly, Maureen T. 8,9 Kessler, Larry 10; Affiliation: 1: Center for Health Studies, Group Health Cooperative, Seattle, WA, USA. 2: University of Washington, School of Public Health and Community Medicine, Seattle, WA, USA. 3: Kaiser Permanente, Denver, CO, USA. 4: Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 5: HMO Research Network's Center for Education and Research on Therapeutics, , Worcester, MA, USA. 6: Meyers Primary Care Institute, Worcester, MA, USA. 7: HealthPartners Research Foundation, Minneapolis, MN, USA. 8: Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA, USA. 9: Menopause Consultation Service, Harvard Vanguard Medical Associates, Boston, MA, USA. 10: Office of Science and Technology, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA.; Source Info: Apr2005, Vol. 20 Issue 4, p350; Subject Term: COMORBIDITY; Subject Term: WOMEN -- Health; Subject Term: EPIDEMIOLOGY; Subject Term: ESTROGEN; Subject Term: CORONARY heart disease; Subject Term: ENDOCRINE diseases; Author-Supplied Keyword: estrogen; Author-Supplied Keyword: fracture; Author-Supplied Keyword: hormone therapy; Author-Supplied Keyword: menopause; Author-Supplied Keyword: women; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1525-1497.2005.04059.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mayfield Arnold, Elizabeth
AU - Goldston, David B.
AU - Walsh, Adam K.
AU - Reboussin, Beth A.
AU - Sergent Daniel, Stephanie
AU - Hickman, Enith
AU - Wood, Frank B.
T1 - Severity of Emotional and Behavioral Problems Among Poor and Typical Readers.
JO - Journal of Abnormal Child Psychology
JF - Journal of Abnormal Child Psychology
Y1 - 2005/04//
VL - 33
IS - 2
M3 - Article
SP - 205
EP - 217
SN - 00910627
AB - The purpose of this study was to examine the severity of behavioral and emotional problems among adolescents with poor and typical single word reading ability (N = 188) recruited from public schools and followed for a median of 2.4 years. Youth and parents were repeatedly assessed to obtain information regarding the severity and course of symptoms (depression, anxiety, somatic complaints, aggression, delinquent behaviors, inattention), controlling for demographic variables and diagnosis of ADHD. After adjustment for demographic variables and ADHD, poor readers reported higher levels of depression, trait anxiety, and somatic complaints than typical readers, but there were no differences in reported self-reported delinquent or aggressive behaviors. Parent reports indicated no differences in depression, anxiety or aggression between the two groups but indicated more inattention, somatic complaints, and delinquent behaviors for the poor readers. School and health professionals should carefully assess youth with poor reading for behavioral and emotional symptoms and provide services when indicated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Abnormal Child Psychology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BEHAVIOR disorders in adolescence
KW - READING disability
KW - EMOTIONAL problems of teenagers
KW - ADOLESCENT psychopathology
KW - PSYCHOLOGY of reading
KW - PARENT & child
KW - adolescents
KW - emotional/behavioral problems.
KW - poor reading
N1 - Accession Number: 16483497; Mayfield Arnold, Elizabeth 1; Email Address: earnol@wfubmc.edu. Goldston, David B. 2 Walsh, Adam K. 1 Reboussin, Beth A. 3 Sergent Daniel, Stephanie 1 Hickman, Enith 1 Wood, Frank B. 4; Affiliation: 1: Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine 2: Department of Psychiatry, Duke University School of Medicine 3: Department of Public Health Sciences; currently at United States Department of Health and Human Services 4: Section on Neuropsychology, Wake Forest University School of Medicine.; Source Info: Apr2005, Vol. 33 Issue 2, p205; Subject Term: BEHAVIOR disorders in adolescence; Subject Term: READING disability; Subject Term: EMOTIONAL problems of teenagers; Subject Term: ADOLESCENT psychopathology; Subject Term: PSYCHOLOGY of reading; Subject Term: PARENT & child; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: emotional/behavioral problems.; Author-Supplied Keyword: poor reading; Number of Pages: 13p; Document Type: Article
L3 - 10. 1007/s 10802-005-1828-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16483497&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wu, John Z.
AU - Dong, Ren G.
AU - Schopper, Aaron W.
T1 - Response to Dr. K. Miller (Re: Most recent results in the biomechanics of the brain)
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2005/04//
VL - 38
IS - 4
M3 - Letter
SP - 969
EP - 969
SN - 00219290
N1 - Accession Number: 16392795; Wu, John Z. 1; Email Address: jwu@cdc.gov Dong, Ren G. 1 Schopper, Aaron W. 1; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Apr2005, Vol. 38 Issue 4, p969; Number of Pages: 1p; Document Type: Letter
L3 - 10.1016/j.jbiomech.2004.03.033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Djordje Medan
AU - Liying Wang
AU - David Toledo
AU - Bin Lu
AU - Christian Stehlik
AU - Bing-Hua Jiang
AU - Xianglin Shi
AU - Yon Rojanasakul
T1 - Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages.
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
Y1 - 2005/04//
VL - 203
IS - 1
M3 - Article
SP - 78
EP - 84
SN - 00219541
AB - Although reactive oxygen species (ROS) have long been suspected to play a key role in Fas (CD95)-induced cell death, the identity of specific ROS involved in this process and the relationship between apoptotic and necrotic cell death induced by Fas are largely unknown. Using electron spin resonance (ESR) spectroscopy, we showed that activation of Fas receptor by its ligand (FasL) in macrophages resulted in a rapid and transient production of hydrogen peroxide (H2O2) and hydroxyl radicals (OH). The response was visible as early as 5 min and peaked at approximately 45 min post-treatment. Morphological analysis of total death response (apoptosis vs. necrosis) showed dose and time dependency with apoptosis significantly increased at 6 h after the treatment, while necrosis remained at a baseline level. Only at a 35-fold increase in apoptosis did necrosis become significant. Inhibition of apoptosis by a pan-caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-(OMe) fluoromethyl ketone (zVAD-fmk), significantly inhibited cell necrosis, indicating the linkage between the two events. Catalase (H2O2 scavenger) and deferoxamine (OH scavenger) effectively inhibited the total death response as well as the ESR signals, while superoxide dismutase (SOD) (O2- scavenger) had minimal effects. These results established the role for H2O2 and OH as key participants in Fas-induced cell death and indicated apoptosis as a primary mode of cell death preceding necrosis. Because the Fas death pathway is implicated in various inflammatory and immunologic disorders, utilization of antioxidants and apoptosis inhibitors as potential therapeutic agents may be advantageous. 2004 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cellular Physiology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CONNECTIVE tissue cells
KW - RETICULO-endothelial system
KW - MANGANESE enzymes
N1 - Accession Number: 18465158; Djordje Medan 1 Liying Wang 2 David Toledo 3 Bin Lu 1 Christian Stehlik 4 Bing-Hua Jiang 4 Xianglin Shi 2 Yon Rojanasakul 1; Affiliation: 1: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 2: ment of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, 1 , Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: ment of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, 1 , Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 2 , Merck & Co., Pharmaceutical Research Department, West Point, Pennsylvania 4: ment of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, 1 , Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 2 , Merck & Co., Pharmaceutical Research Department, West Point, Pennsylvania, 3 , Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia; Source Info: Apr2005, Vol. 203 Issue 1, p78; Subject Term: APOPTOSIS; Subject Term: CONNECTIVE tissue cells; Subject Term: RETICULO-endothelial system; Subject Term: MANGANESE enzymes; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Noah, Charles W.
AU - Shaw, Christine I.
AU - Ikeda, Jack S.
AU - Kreuzer, Karen S.
AU - Sofos, John N.
T1 - Development of Green Fluorescent Protein-Expressing Bacterial Strains and Evaluation for Potential Use as Positive Controls in Sample Analyses.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/04//
VL - 68
IS - 4
M3 - Article
SP - 680
EP - 686
SN - 0362028X
AB - Strains of enterohemorrhagic Escherichia coli O157:H7 and Salmonella Typhimurium were engineered to express the gene for a modified green fluorescent protein (GFP) and were evaluated for potential use as positive controls in sample analyses. The strains fluoresced when observed as colonies with a handheld UV lamp or as individual cells under a fluorescent micro- scope. The strains maintained their fluorescence following growth in three series of transfer experiments including 8 to 11 passages from broth to broth and twice for 15 consecutive transfers from broth onto Trypticase soy agar plates. Cultures also maintained stability in the ability to fluoresce when agar plates were refrigerated (4°C) for up to 12 days. Growth characteristics of the GFP-positive strains were comparable to those of corresponding control strains. The GFP-positive strains were suc- cessfully identified using rapid diagnostic methods and were differentiated from their corresponding non-GFP strains by pulsed- field gel electrophoresis but not by repetitive extragenic palindromic PCR. The GFP-positive and the control strains were recovered successfully from individually inoculated food samples (Feta cheese, raw shrimp, cooked shrimp, and cooked crawfish). However, in one Feta cheese sample and one raw shrimp sample inoculated with combined GFP-positive and GFP- negative cultures, colonies of the GFP-positive strains were not observed under UV light; fluorescing cells in one of the inoculated samples (raw shrimp) were revealed by microscopy. In general, the isolates from the inoculated foods were GFP positive by microscopic examination; the pure isolates could also be restreaked onto Trypticase soy agar, and colonies could be visually examined under UV light. Because GFP strains are not known to occur naturally in the environment, the use of the Salmonella GFP-positive strain may offer advantages as a positive control even when distinct and rare serotypes are available. The GFP-positive E. coli O157:H7 strain may also prove beneficial for use as a positive control strain for sample analyses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Salmonella
KW - Food pathogens
KW - Bacteriology
KW - Green fluorescent protein
N1 - Accession Number: 16753693; Noah, Charles W. 1; Email Address: cnoah@ora.fda.gov; Shaw, Christine I. 1; Ikeda, Jack S. 2,3; Kreuzer, Karen S. 1; Sofos, John N. 2; Affiliations: 1: Denver District Office, Food and Drug Administration, 6th Avenue and Kipling Street, Denver, Colorado 80225; 2: Department of Animal Sciences, Colorado State University, Fort Collins, Colorado 80523, USA; 3: Department of Microbiology, University of Illinois, 601 South Goodwin Avenue, Urbana, IL 61801, USA; Issue Info: Apr2005, Vol. 68 Issue 4, p680; Thesaurus Term: Escherichia coli; Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Bacteriology; Subject Term: Green fluorescent protein; Number of Pages: 7p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Blau, D. M.
AU - McCluskey, B. J.
AU - Ladely, S. R.
AU - Dargatz, D. A.
AU - Fedorka-Cray, P. J.
AU - Ferris, K. E.
AU - Headrick, M. L.
T1 - Salmonella in Dairy Operations in the United States: Prevalence and Antimicrobial Drug Susceptibility.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/04//
VL - 68
IS - 4
M3 - Article
SP - 696
EP - 702
SN - 0362028X
AB - Salmonella serotypes are important foodborne pathogens of humans that can be acquired through consumption of contaminated meat and dairy products. Salmonella infection also can be a significant animal health issue. As part of a national study of U.S. dairy operations conducted between March and September 2002, fecal samples were collected from representative cows in 97 dairy herds in 21 states and were cultured to determine the prevalence of Salmonella shedding. Salmonella was recovered from the feces of at least one cow in 30.9% of the herds. Overall, 7.3% of fecal samples were culture positive for Salmonella. The three most frequently recovered serotypes were Salmonella Meleagridis (24.1%), Salmonella Montevideo (11.9%), and Salmonella Typhimurium (9.9%). The susceptibilities of Salmonella isolates recovered were determined using a panel of 16 antimicrobial drugs. Salmonella isolates recovered from dairy cows had relatively little resistance to these anti- microbial agents; 83.0% of the isolates were susceptible to all antimicrobials tested. This study provides updated information on the prevalence and susceptibility patterns of Salmonella in dairy herds and on cow and herd characteristics. These data contribute to our understanding of the ecology of Salmonella in the dairy farm environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food pathogens
KW - Food adulteration & inspection
KW - Anti-infective agents
KW - Medical microbiology
N1 - Accession Number: 16753695; Blau, D. M. 1; McCluskey, B. J. 1; Ladely, S. R. 2; Dargatz, D. A. 1; Email Address: david.a.dargatz@aphis.usda.gov; Fedorka-Cray, P. J. 2; Ferris, K. E. 3; Headrick, M. L. 4; Affiliations: 1: Centers for Epidemiology and Animal Health, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Fort Collins, Colorado 80526–8117; 2: Antimicrobial Resistance Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia 30604; 3: National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Ames, Iowa 50010; 4: Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland 20855, USA; Issue Info: Apr2005, Vol. 68 Issue 4, p696; Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Food adulteration & inspection; Thesaurus Term: Anti-infective agents; Thesaurus Term: Medical microbiology; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 7p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rubin, Steven A.
AU - Afzal, Muhammad A.
AU - Powell, Caroline L.
AU - Bentley, Maureen L.
AU - Auda, Ghazi R.
AU - Taffs, Rolf E.
AU - Carbone, Kathryn M.
T1 - The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/04//4/1/2005
VL - 191
IS - 7
M3 - Article
SP - 1123
EP - 1128
SN - 00221899
AB - Because of the highly neurotropic and neurovirulent properties of wild-type mumps viruses, most national regulatory organizations require neurovirulence testing of virus seeds used in the production of mumps vaccines. Such testing has historically been performed in monkeys; however, some data suggest that testing in monkeys does not necessarily discriminate among the relative neurovirulent risks of mumps virus strains. To address this problem, a collaborative study was initiated by the National Institute for Biological Standards and Control in the United Kingdom and the Food and Drug Administration in the United States, to test a novel rat-based mumps virus neurovirulence safety test. Results indicate that the assay correctly assesses the neurovirulence potential of mumps viruses in humans and is robust and reproducible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - MUMPS
KW - VACCINES
KW - MUMPS -- Vaccination
KW - MONKEYS as laboratory animals
KW - VACCINATION
N1 - Accession Number: 16345768; Rubin, Steven A. 1; Email Address: rubins@cber.fda.gov Afzal, Muhammad A. 2 Powell, Caroline L. 2 Bentley, Maureen L. 2 Auda, Ghazi R. 2 Taffs, Rolf E. 3 Carbone, Kathryn M. 4; Affiliation: 1: Office of Vaccines Research and Review, Food and Drug Adminstration, Bethesda, Maryland 2: Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Herts, United Kingdom 3: Office of Blood Research and Review, Food and Drug Adminstration, Bethesda, Maryland 4: Office of the Director, Center for Biologics Evaluation and Research, Food and Drug Adminstration, Bethesda, Maryland; Source Info: 4/1/2005, Vol. 191 Issue 7, p1123; Subject Term: VIRUSES; Subject Term: MUMPS; Subject Term: VACCINES; Subject Term: MUMPS -- Vaccination; Subject Term: MONKEYS as laboratory animals; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105869902
T1 - Center for Substance Abuse Treatment (CSAT), substance Abuse and Mental Health Services Administration (SAMHSA), news from the director, CSAT.
AU - Clark HW
Y1 - 2005/04//2005-2007
N1 - Accession Number: 105869902. Language: English. Entry Date: 20080328. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9707735.
KW - Drug Rehabilitation Programs
KW - Quality Improvement
KW - Substance Abuse and Mental Health Services Administration
KW - Substance Dependence -- Rehabilitation
KW - Hepatitis C -- Prevention and Control
KW - HIV Infections -- Prevention and Control
KW - Natural Disasters
KW - Overdose
KW - United States
KW - Viral Hepatitis Vaccines
SP - 13
EP - 16
JO - Journal of Maintenance in the Addictions
JF - Journal of Maintenance in the Addictions
JA - J MAINTENANCE ADDICT
VL - 3
IS - 2-4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1091-1332
AD - Center for Substance Abuse Treatment (SAMHSA), 1 Choke Cherry Road, Room 5-1020, rockville, MD 20857; westley.clark@samhsa.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Malkin, Robert
AU - Hudock, Stephen
AU - Hayden, Charles
AU - Lentz, Thomas
AU - Topmiller, Jennifer
AU - Niemeier, Richard
T1 - An Assessment of Occupational Safety and Health Hazards in Selected Small Businesses Manufacturing Wood Pallets—Part 1. Noise and Physical Hazards.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2005/04//
VL - 2
IS - 4
M3 - Article
SP - D18
EP - D21
SN - 15459624
AB - Describes the assessments and suggestions to minimize ergonomic and noise exposures from the occupational risk factors at wood pallet manufacturing facilities. Methods used for taking noise measurements and to observe working activities and to assess ergonomic conditions and potential musculoskeletal stressors; Engineering and administrative controls and personal protective equipment that can be employed for preventing noise exposure; Suggestion for companies to purchase or design adjustable tables to be placed at heights correct for each user.
KW - INDUSTRIAL safety
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL management
KW - PALLET industry
KW - FOREST products industry
KW - MANUFACTURES
N1 - Accession Number: 16176125; Malkin, Robert 1 Hudock, Stephen 2 Hayden, Charles 2 Lentz, Thomas 1 Topmiller, Jennifer 2 Niemeier, Richard 1; Affiliation: 1: National Institute for OccupationalSafety and Health, Education and Information Division, Cincinnati, Ohio 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio; Source Info: Apr2005, Vol. 2 Issue 4, pD18; Subject Term: INDUSTRIAL safety; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL management; Subject Term: PALLET industry; Subject Term: FOREST products industry; Subject Term: MANUFACTURES; NAICS/Industry Codes: 321999 All Other Miscellaneous Wood Product Manufacturing; NAICS/Industry Codes: 484223 Forest products trucking, local; NAICS/Industry Codes: 484233 Forest products trucking, long distance; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 321113 Sawmills; NAICS/Industry Codes: 339999 All Other Miscellaneous Manufacturing; NAICS/Industry Codes: 339990 All other miscellaneous manufacturing; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 321920 Wood Container and Pallet Manufacturing; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/15459620590921499
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106512184
T1 - Evaluation of the NIOSH MWF total particulate matter: thoracic particulate matter conversion factor in a machining environment...National Institute for Occupational Safety and Health... Metalworking Fluids
AU - Reh BD
AU - Harney JM
AU - McCleery RE
AU - Mueller CA
Y1 - 2005/04//
N1 - Accession Number: 106512184. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D31-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Occupational Hazards
KW - Particulate Matter
KW - Education, Continuing (Credit)
KW - Linear Regression
KW - Metals -- Adverse Effects
KW - National Institute for Occupational Safety and Health
KW - Human
SP - 239
EP - 243
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Worker exposures to metalworking fluids were characterized at a plant that produced air compressors. Full-shift, side-by-side air samples (n = 147) were collected and analyzed for total particulate matter, extractable total particulate matter, thoracic particulate matter, and extractable thoracic particulate matter. The thoracic particulate matter geometric mean of 0.32 m/m (3)was below the National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit (REL) of 0.4 mg/m (3). The total particulate matter geometric mean of 0.52 mg/m (3), however, was above 0.5 mg/m (3), the total particulate matter concentration offered as a surrogate REL in the NIOSHCriteria for a Recommended Standard for Occupational Exposure to Metalworking Fluids.[1]Of the 83 total particulate matter results that were at or above smash 0.5 mg/m (3), only 50 (60%) of the corresponding thoracic particulate matter results were at or above 0.4 mg/m (3). These data indicated a conversion factor of 1.65 between thoracic particulate matter and total particulate matter concentrations and 1.40 between thoracic extractable particulate matter and total extractable concentrations. These factors were significantly different from the 1.25 used to compare total particulate matter with thoracic particulate matter concentrations in the NIOSHCriteria Document[1](p < 0.01) and call into question the validity of a universal conversion factor. The authors conclude that thoracic particulate matter exposure assessment should be done directly. In terms of protecting the worker, however, the 1.25 conversion factor appeared to be conservative since each time a total particulate matter result was below 0.5 mg/m (3), its paired thoracic particulate matter measurement was below 0.4 mg/m (3).
SN - 1545-9624
AD - U.S. Public Health Service/Division of Federal Occupational Health, Westborough, MA
U2 - PMID: 15788385.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106512169
T1 - Ergonomics. An assessment of occupational safety and health hazards in selected small businesses manufacturing wood pallets -- part 1. Noise and physical hazards.
AU - Malkin R
AU - Hudock SD
AU - Hayden C
AU - Lentz TJ
AU - Topmiller J
AU - Niemeier RW
A2 - Schneider S
Y1 - 2005/04//
N1 - Accession Number: 106512169. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Noise
KW - Occupational Safety
KW - Ergonomics
KW - Interviews
KW - National Institute for Occupational Safety and Health
KW - Human
SP - D18
EP - 21
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Researchers from the National Institute for Occupational Safety and Health (NIOSH) investigated occupational safety and health concerns in the small business wood pallet manufacturing industry. The investigation consisted of interviews with employees and managers and walkthrough tours of seven wood pallet manufacturing companies while taking measurements at several of them. The purpose of the project was to assess and characterize occupational safety and health hazards in the industry and to offer suggestions as to how exposure to the hazards might be mitigated. Noise level measurements and ergonomic observations were made at each facility. This column describes the assessments and suggestions to minimize ergonomic and noise exposures from the occupational risk factors at the facilities. (A companion paper will address the respiratory hazards evaluated during the investigation: i.e., Part 2--airborne particulate and chemical hazards.) The main findings are as follows:1. Short-term (<8 hours) noise measurements associated with certain machines and procedures at all sites produced noise levels greater than 90 dBA, which is the Occupational Safety and Health Administration permissible noise exposure limit' based on an 8-hour time-weighted average (TWA).2. Ergonomics-related deficiencies noted in pallet manufacturing included stretching to assemble pallets, bending to retrieve wood, lifting loads that were too heavy, and twisting and turning while lifting those loads.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, OH
U2 - PMID: 15764543.
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DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Maruvada, Subha
AU - Harris, Gerald R.
T1 - Acoustic regulation of extracorporeal shock wave (ESW) therapy devices in the U.S.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2005/04//
VL - 117
IS - 4
M3 - Abstract
SP - 2382
EP - 2382
SN - 00014966
AB - The focused, large amplitude pressure fields produced by ESW lithotripsy devices were shown in the early 1980s to provide an efficient means for fragmenting urinary tract calculi. More recently, orthopedic applications of intense pressure pulses for pain relief and fracture healing have been developed. Under the US Medical Device Amendments of 1976, ESW therapy devices were deemed Class III, meaning that a pre-market application typically would be supported by both pre-clinical and clinical studies. This classification still applies, except for ESW lithotripters indicated for fragmenting kidney and ureteral calculi. These devices were reclassified to Class II in 2000, resulting in a simpler path to market in which a demonstration of substantial equivalence to a currently marketed device is sufficient. As part of its regulatory responsibility to address the safety and effectiveness of these devices, particularly with regard to acoustic output, the US Food and Drug Administration has recognized two International Electrotechnical Commission (IEC) standards for ESW lithotripters, one covering field measurements (IEC 61846) and the other dealing with labeling and other safety aspects (IEC 60601-2-36). Although these standards were designed primarily for lithotripsy, the FDA has used them where applicable in the regulatory analysis of other ESW therapy devices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - EXTRACORPOREAL shock wave lithotripsy
KW - URINARY calculi
KW - STANDARDS
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20264383; Maruvada, Subha 1; Email Address: subha.maruvada@fda.hhs.gov Harris, Gerald R. 1; Affiliation: 1: Food and Drug Administration, Ctr. for Devices and Radiological Health, 12725 Twinbrook Pkwy., Rockville, MD 20852; Source Info: Apr2005, Vol. 117 Issue 4, p2382; Subject Term: MEDICAL equipment; Subject Term: EXTRACORPOREAL shock wave lithotripsy; Subject Term: URINARY calculi; Subject Term: STANDARDS; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 1p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Jones, Peter
AU - Sundlof, Stephen F.
T1 - Pharmacovigilance of veterinary medicines.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2005/04//
VL - 28
IS - 2
M3 - Editorial
SP - 127
EP - 128
PB - Wiley-Blackwell
SN - 01407783
AB - Focuses on the laboratory toxicology study concerning veterinary medicines and their adverse reactions in animals. Benefits of pharmacovigilance; Advantages of having effective pharmacovigilance in place; Details of the experiments.
KW - VETERINARY medicine
KW - MEDICINE
KW - ANIMAL health
KW - PHARMACOLOGY
KW - PHARMACY
N1 - Accession Number: 16730726; Jones, Peter 1 Sundlof, Stephen F. 2; Affiliation: 1: Head of Veterinary Medicines and Inspections, European Medicines Agency, London, UK 2: Director, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD, USA; Source Info: Apr2005, Vol. 28 Issue 2, p127; Subject Term: VETERINARY medicine; Subject Term: MEDICINE; Subject Term: ANIMAL health; Subject Term: PHARMACOLOGY; Subject Term: PHARMACY; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1111/j.1365-2885.2005.00653.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16730726&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Illei, G.G.
T1 - On the road to the optimal treatment of lupus nephritis: are we there yet?
JO - Lupus
JF - Lupus
Y1 - 2005/04//
VL - 14
IS - 4
M3 - Article
SP - 263
EP - 264
PB - Sage Publications Inc.
SN - 09612033
AB - Comments on research efforts to develop an optimal treatment process for lupus nephritis. Improvement in the prognosis of proliferative lupus nephritis by aggressive immunosuppressive therapy; Research findings; Implications on studies of lupus.
KW - LUPUS nephritis
KW - SYSTEMIC lupus erythematosus
KW - RENAL manifestations of general diseases
KW - GLOMERULONEPHRITIS
KW - COLLAGEN diseases
KW - AUTOIMMUNE diseases
KW - SKIN diseases
KW - VASCULAR diseases
N1 - Accession Number: 16595771; Illei, G.G. 1; Affiliation: 1: Sjören's Syndrome Clinic, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA; Source Info: 2005, Vol. 14 Issue 4, p263; Subject Term: LUPUS nephritis; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: RENAL manifestations of general diseases; Subject Term: GLOMERULONEPHRITIS; Subject Term: COLLAGEN diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: SKIN diseases; Subject Term: VASCULAR diseases; Number of Pages: 2p; Document Type: Article
L3 - 10.1191/0961203305lu2101ed
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16595771&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reed, Meribeth Meixner
T1 - Describing the Life Cycle of U.S. Marine Hospital #17, Port Townsend, Washington, 1855-1933.
JO - Military Medicine
JF - Military Medicine
Y1 - 2005/04//
VL - 170
IS - 4
M3 - Article
SP - 259
EP - 267
PB - AMSUS
SN - 00264075
AB - This study was undertaken to determine why U.S. Marine Hospital #17, Port Townsend, Washington, closed at the peak of its utilization. A social history approach was taken, examining the hospital's developmental changes in the context of its role in the larger society. Both firsthand and interpretive sources were reviewed, and numerous photographs and drawings confirmed the hospital was an active participant in the economy. Regarding the hospital's transitions over time as a life cycle was a useful organizing framework. Inpatient census patterns as a measure of the hospital's growth and development in-formed and enlightened this study. It became clear the Marine Hospital responded to and influenced events in the Port Townsend seaport whose importance diminished when other port cities at the base of the Puget Sound began and sustained rapid growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MILITARY hospitals
KW - MILITARY medicine
KW - HOSPITALS
KW - HEALTH facilities
KW - MEDICAL economics
N1 - Accession Number: 16788284; Reed, Meribeth Meixner 1; Email Address: mreed@hrsa.gov; Affiliation: 1: U.S. Department of Health and Human Services, Health Resources and Services Administration, 18-31 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; Source Info: Apr2005, Vol. 170 Issue 4, p259; Subject Term: MILITARY hospitals; Subject Term: MILITARY medicine; Subject Term: HOSPITALS; Subject Term: HEALTH facilities; Subject Term: MEDICAL economics; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 9p; Illustrations: 3 Black and White Photographs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106491011
T1 - AMSUS History of Military Medicine Essay Award: describing the life cycle of U.S. Marine Hospital #17, Port Townsend, Washington, 1855-1933.
AU - Reed MM
Y1 - 2005/04//
N1 - Accession Number: 106491011. Language: English. Entry Date: 20050729. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2984771R.
KW - Hospitals, Military -- History -- Washington
KW - Hospitals, Military -- Legislation and Jurisprudence
KW - Washington
SP - 259
EP - 267
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 170
IS - 4
CY - Bethesda, Maryland
PB - AMSUS
AB - This study was undertaken to determine why U.S. Marine Hospital #17, Port Townsend, Washington, closed at the peak of its utilization. A social history approach was taken, examining the hospital's developmental changes in the context of its role in the larger society. Both firsthand and interpretive sources were reviewed, and numerous photographs and drawings confirmed the hospital was an active participant in the economy. Regarding the hospital's transitions over time as a life cycle was a useful organizing framework. Inpatient census patterns as a measure of the hospital's growth and development informed and enlightened this study. It became clear the Marine Hospital responded to and influenced events in the Port Townsend seaport whose importance diminished when other port cities at the base of the Puget Sound began and sustained rapid growth.
SN - 0026-4075
AD - U.S. Department of Health and Human Services, Health Resources and Services Administration, 18-31 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; mreed@hrsa.gov
U2 - PMID: 15916290.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106491011&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bloch, A. B.
AU - Mowery, P. D.
AU - Caraballo, R. S.
AU - Malarcher, A. M.
AU - Pechacek, T.
AU - Husten, C. G.
AU - Carmona, R.
T1 - Tobacco Use, Access, and Exposure to Tobacco in Media Among Middle and High School Students -- United States, 2004. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04//4/1/2005
VL - 54
IS - 12
M3 - Article
SP - 297
EP - 301
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Presents the results of the National Youth Tobacco Survey conducted by the U.S. Centers for Disease Control and Prevention from 2002 to 2004. Data on the percentage of middle school students and their tobacco habit; Decline in the prevalence of youth smoking; Limitations of the study.
KW - YOUTH -- Substance use
KW - CIGARETTE smokers
KW - TOBACCO use
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 16639945; Bloch, A. B. 1 Mowery, P. D. 1 Caraballo, R. S. 1 Malarcher, A. M. 1 Pechacek, T. 1 Husten, C. G. 1 Carmona, R. 2; Affiliation: 1: Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, CDC 2: Office of the Surgeon General, National Center for Chronic Disease Prevention and Health Promotion, CDC; Source Info: 4/1/2005, Vol. 54 Issue 12, p297; Subject Term: YOUTH -- Substance use; Subject Term: CIGARETTE smokers; Subject Term: TOBACCO use; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lucas, A.
AU - Doane, M.
AU - Rosenberg, J.
AU - Gilliss, D.
AU - Duffey, P.
AU - Sesline, D.
AU - Lindquist, D.
AU - Das, R.
AU - Materna, B.
AU - Vugia, D.
AU - Reagan, S.
AU - Fischer, M.
AU - Marano, N.
AU - Hoffmaster, A.
AU - Semenova, V.
AU - Martin, S.
AU - Quinn, C.
AU - Patel, J.
AU - Kiefer, M.
AU - Ehrenberg, R.
T1 - Inadvertent Laboratory Exposure to Bacillus anthracis -- California, 2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04//4/1/2005
VL - 54
IS - 12
M3 - Article
SP - 301
EP - 304
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Comments on the unintentional exposure of workers to Bacillus anthracis at the Children's Hospital Oakland Research Institute in California. Overview of research being conducted at the laboratory; Importance of the implementation of BSL-2 practices among laboratory personnel who are exposed to infectious cultures; Recommendation on routine anthrax vaccination of persons who work with production quantities or concentrations of B. anthracis cultures.
KW - BACILLUS anthracis
KW - LABORATORY infections
KW - ANTHRAX -- Vaccination
KW - BACTERIAL diseases -- Vaccination
KW - RESEARCH institutes
KW - CALIFORNIA
N1 - Accession Number: 16639951; Lucas, A. 1 Doane, M. 2 Rosenberg, J. 2 Gilliss, D. 2 Duffey, P. 2 Sesline, D. 2 Lindquist, D. 2 Das, R. 2 Materna, B. 2 Vugia, D. 2 Reagan, S. 3 Fischer, M. 3 Marano, N. 3 Hoffmaster, A. 3 Semenova, V. 3 Martin, S. 3 Quinn, C. 3 Patel, J. 4 Kiefer, M. 5 Ehrenberg, R. 5; Affiliation: 1: Children's Hospital Oakland Research Institute 2: California Dept of Health Svcs. 3: Div Bacterial and Myotic Diseases, National Center for Infectious Diseases 4: Div of Healthcare Quality Promotion, National Center for Infectious Diseases 5: National Institute for Occupational Safety and Health; Source Info: 4/1/2005, Vol. 54 Issue 12, p301; Subject Term: BACILLUS anthracis; Subject Term: LABORATORY infections; Subject Term: ANTHRAX -- Vaccination; Subject Term: BACTERIAL diseases -- Vaccination; Subject Term: RESEARCH institutes; Subject Term: CALIFORNIA; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Corinne L.
AU - Boucher, Philip E.
AU - Stibitz, Scott
AU - Cotter, Peggy A.
T1 - BvgA functions as both an activator and a repressor to control Bvgi phase expression ofbipAinBordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2005/04//
VL - 56
IS - 1
M3 - Article
SP - 175
EP - 188
PB - Wiley-Blackwell
SN - 0950382X
AB - TheBordetella bipAgene is expressed maximally when the BvgAS phosphorelay is semi-active, i.e. in the Bvg-intermediate (Bvgi) phase. We used a BvgA-FeBABE cleavage approach together with site-directed mutagenesis andbipA–lacZfusion analyses to determine precisely where BvgA-phosphate (BvgA∼P) binds at thebipApromoter and how that binding contributes to the complex transcription pattern displayed bybipA. BvgA∼P bound with high affinity and cooperatively with RNAP to sequences at thebipApromoter immediately 5′ to and overlapping those bound by RNAP to activate transcription under Bvgi phase conditions.bipAtherefore, likefhaB, appears to be similar to classical class-II promoters with regard to the mechanism by which its transcription is activated. BvgA∼P bound with relatively low affinity to sequences immediately 3′ of those bound by RNAP at thebipApromoter and this binding mediated repression ofbipAtranscription under Bvg+ phase conditions. BvgA∼P binding to these sequences occurred simultaneously, if not cooperatively, with RNAP, indicating that BvgA∼P repressesbipAexpression by inhibiting transcription initiation and/or elongation, rather than by competing with RNAP for binding. AsbipAis the first Bvgi phase gene to be characterized, and the first gene shown to be repressed by BvgA∼P directly, our results will provide a basis for comparison as additional Bvg-regulated genes are identified and characterized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA pertussis
KW - MUTAGENESIS
KW - IMMUNE response
KW - GENE expression
KW - TRANSCRIPTION factors
KW - BRUCELLACEAE
KW - MUTATION (Biology)
N1 - Accession Number: 16341788; Williams, Corinne L. 1 Boucher, Philip E. 2 Stibitz, Scott 2 Cotter, Peggy A. 1; Email Address: cotter@lifesci.ucsb.edu; Affiliation: 1: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106-9610, USA 2: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Apr2005, Vol. 56 Issue 1, p175; Subject Term: BORDETELLA pertussis; Subject Term: MUTAGENESIS; Subject Term: IMMUNE response; Subject Term: GENE expression; Subject Term: TRANSCRIPTION factors; Subject Term: BRUCELLACEAE; Subject Term: MUTATION (Biology); Number of Pages: 14p; Document Type: Article
L3 - 10.1111/j.1365-2958.2004.04526.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106623304
T1 - Device safety. Sounding the alarm for I.V. infiltration.
AU - Marders J
Y1 - 2005/04//
N1 - Accession Number: 106623304. Language: English. Entry Date: 20050429. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Alarm Systems
KW - Equipment Failure
KW - Equipment Safety
KW - Extravasation of Diagnostic and Therapeutic Materials -- Prevention and Control
KW - Infusion Pumps -- Adverse Effects
KW - Extravasation of Diagnostic and Therapeutic Materials -- Nursing
SP - 18
EP - 20
JO - Nursing
JF - Nursing
JA - NURSING
VL - 35
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 15818227.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Meikle, Susan F.
AU - Steiner, Claudia A.
AU - Zhang, Jun
AU - Lawrence, William L.
T1 - A National Estimate of the Elective Primary Cesarean Delivery Rate.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2005/04//
VL - 105
IS - 4
M3 - Article
SP - 751
EP - 756
SN - 00297844
AB - OBJECTIVE: We describe national trends for elective primary cesarean delivery from 1994 to 2001, with attention to changes in indications. METHODS: We used data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Cesarean deliveries were identified by International Classification of Diseases, 9th Revision, Clinical Modification procedure and diagnostic codes; V codes identified all types of deliveries for denominators. Twelve indications for elective primary cesarean delivery were targeted. International Classification of Diseases, 9th Revision, Clinical Modification coding changes were also evaluated. RESULTS: After excluding women who had labored and previous cesarean deliveries, elective primary cesarean deliveries rose from 19.7% of all cesarean deliveries in 1994 to 28.3% in 2001, an increase of approximately 43.6%. The use of the identified indications for elective primary cesarean delivery increased for codes representing malpresentation, antepartum bleeding, hypertension and severe hypertension, macrosomia, unengaged head, preterm gestation, and maternal soft tissue disorders. Coding for herpes, multiple gestation, other uterine scar, and congenital central nervous system remained the same. Additionally, a new 1998 code for fetal heart rate abnormalities was rapidly adopted during the study period. CONCLUSION: A national estimate of the elective primary cesarean delivery rate shows a rising trend. Additionally, coded indications for these procedures are shifting. Further examination into the use and clinical implications of indications through national surveillance for elective primary cesarean delivery is important for future obstetric practice. A revision of the terminology classification used to identify indications for cesarean delivery procedures would aid in this effort. [ABSTRACT FROM AUTHOR]
AB - Copyright of Obstetrics & Gynecology is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CESAREAN section
KW - DELIVERY (Obstetrics)
KW - MEDICAL care costs
KW - OBSTETRICS
KW - LABOR complications (Obstetrics)
KW - SURVEYS
N1 - Accession Number: 18199411; Meikle, Susan F. 1,2; Email Address: smeikle@ahrq.gov Steiner, Claudia A. 1,2 Zhang, Jun 1,2 Lawrence, William L. 1,2; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland; Source Info: Apr2005, Vol. 105 Issue 4, p751; Subject Term: CESAREAN section; Subject Term: DELIVERY (Obstetrics); Subject Term: MEDICAL care costs; Subject Term: OBSTETRICS; Subject Term: LABOR complications (Obstetrics); Subject Term: SURVEYS; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1097/01.AOG.0000157435.67138.78
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106626918
T1 - A national estimate of the elective primary cesarean delivery rate.
AU - Meikle SF
AU - Steiner CA
AU - Zhang J
AU - Lawrence WL
Y1 - 2005/04//
N1 - Accession Number: 106626918. Language: English. Entry Date: 20050506. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0401101.
KW - Cesarean Section -- Trends
KW - Surgery, Elective -- Trends
KW - Adult
KW - Algorithms
KW - Confidence Intervals
KW - Female
KW - Fetal Macrosomia
KW - Fetus
KW - Heart Rate, Fetal
KW - Labor Complications
KW - Labor Presentation
KW - Maternal Age
KW - Pregnancy
KW - United States
KW - Human
SP - 751
EP - 756
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
JA - OBSTET GYNECOL
VL - 105
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0029-7844
AD - Agency for Healthcare Research and Quality, 540 Gaither Road Rockville, MD 20850; smeikle@ahrq.gov
U2 - PMID: 15802401.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106626918&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Faris, Owen P.
AU - Shein, Mitchell J.
T1 - Government Viewpoint: U.S. Food&Drug Administration: Pacemakers, ICDs and MRI.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 2005/04//
VL - 28
IS - 4
M3 - Editorial
SP - 268
EP - 269
PB - Wiley-Blackwell
SN - 01478389
AB - Focuses on the views of the U.S. Food and Drug Administration on the use of magnetic resonance imaging (MRI) in patients with pacemakers and defibrillators. Information on studies conducted on pacemaker and implanted cardioverter defibrillator patients; Risks in using MRI; Advice on the use of MRI.
KW - MAGNETIC resonance imaging
KW - IMAGING systems in medicine
KW - CARDIAC pacemakers
KW - DEFIBRILLATORS
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 16567837; Faris, Owen P. 1 Shein, Mitchell J. 1; Affiliation: 1: Division of Cardiovascular Devices, Center for Devices and Radiological Health, U.S. Food and Drug Administration Rockville, Maryland; Source Info: Apr2005, Vol. 28 Issue 4, p268; Subject Term: MAGNETIC resonance imaging; Subject Term: IMAGING systems in medicine; Subject Term: CARDIAC pacemakers; Subject Term: DEFIBRILLATORS; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1111/j.1540-8159.2005.50035.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106389452
T1 - Guest editorial. Government viewpoint: U.S. Food & Drug Administration: pacemakers, ICDs and MRI.
AU - Faris OP
AU - Shein MJ
Y1 - 2005/04//
N1 - Accession Number: 106389452. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: del Ojo JL, Moya F, Villalba J, Sanz O, Pavón R, Garcia PD, et al. Is magnetic resonance imaging safe in cardiac pacemaker recipients? (PACING CLIN ELECTROPHYSIOL) Apr2005; 28 (4): 274-278; Gimbel JR, Kanal E, Schwartz KM, Wilkoff BL. Outcome of magnetic resonance imaging (MRI) in selected patients with implantable cardioverter defibrillators (ICDs) (PACING CLIN ELECTROPHYSIOL) Apr2005; 28 (4): 270-273. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7803944.
KW - Defibrillators, Implantable -- Standards
KW - Equipment Safety
KW - Government
KW - Magnetic Resonance Imaging -- Standards
KW - Pacemaker, Artificial -- Standards
KW - Product Labeling
KW - United States Food and Drug Administration
KW - United States
SP - 268
EP - 269
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
JA - PACING CLIN ELECTROPHYSIOL
VL - 28
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0147-8389
AD - Division of Cardiovascular Devices, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland
U2 - PMID: 15826256.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cockburn, Robert
AU - Newton, Paul N.
AU - Agyarko, E. Kyeremateng
AU - Akunylli, Dora
AU - White, Nicholas J.
T1 - The Global Threat of Counterfeit Drugs: Why Industry and Governments Must Communicate the Dangers.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2005/04//
VL - 2
IS - 4
M3 - Article
SP - 302
EP - 308
PB - Public Library of Science
SN - 15491277
AB - Suggests that many pharmaceutical companies and governments are reluctant to publicize the problem to health staff and the public due to the belief that the publicity will harm the sales of brand-name products. Efforts of the U.S. government to address the problem of counterfeit drugs; Absence of reliable accessible databases whereby health workers or the public can access current details of which products are being faked; Examples of counterfeit drugs. INSETS: Recent Examples of Counterfeit Drugs;Box 1. The Pharmaceutical Security Institute.
KW - PHARMACEUTICAL industry
KW - DRUGS
KW - PRODUCT counterfeiting
KW - PUBLICITY
KW - BUSINESS enterprises
KW - PUBLIC administration
N1 - Accession Number: 16858110; Cockburn, Robert; Email Address: rcockburn@libero.it Newton, Paul N. 1 Agyarko, E. Kyeremateng 2 Akunylli, Dora 3 White, Nicholas J. 1,4; Affiliation: 1: Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, United Kingdom 2: Chief Executive, Food and Drug Board, Accra, Ghana 3: Director-General, National Agency for Food and Drug Administration and Control, Lagos, Nigeria 4: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Source Info: Apr2005, Vol. 2 Issue 4, p302; Subject Term: PHARMACEUTICAL industry; Subject Term: DRUGS; Subject Term: PRODUCT counterfeiting; Subject Term: PUBLICITY; Subject Term: BUSINESS enterprises; Subject Term: PUBLIC administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 7p; Illustrations: 3 Color Photographs, 1 Graph; Document Type: Article
L3 - 10.1371/journal.pmed.0020100
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106507940
T1 - Collective review. Blood-borne pathogens among firefighters and emergency medical technicians.
AU - Boal WL
AU - Hales T
AU - Ross CS
Y1 - 2005/04//Apr-Jun2005
N1 - Accession Number: 106507940. Language: English. Entry Date: 20050902. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9703530.
KW - Bloodborne Pathogens
KW - Emergency Medical Technicians
KW - Firefighters
KW - Occupational Exposure
KW - Seroconversion
KW - Hepatitis C -- Epidemiology
KW - HIV Infections -- Epidemiology
KW - Hepatitis B -- Epidemiology
SP - 236
EP - 247
JO - Prehospital Emergency Care
JF - Prehospital Emergency Care
JA - PREHOSPITAL EMERG CARE
VL - 9
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Objective. Firefighters and emergency medical services (EMS) personnel have the potential for occupational exposures to blood, which increases their risk for occupational blood-borne infection. To address this concern, the authors conducted a literature review of occupational blood exposures, the seroprevalence of blood-borne pathogens among these workers, and the seroprevalence of blood-borne pathogens among the patients they serve. Methods. A MEDLINE search was conducted, and all identified articles that described surveys of exposures to blood or surveil-lance of blood-borne infections among firefighters and/or emergency medical technicians (EMTs) in the United States were reviewed. For hepatitis B, only seroprevalence surveys conducted after the 1992 requirement by the Bloodborne Pathogens Standard to offer vaccination to potentially ex-posed employees were included. Results. From these data, the expected number of annual occupational hepatitis C virus seroconversions was estimated to be between 5.8 and 118.9 per 100,000 employee-years for EMT--paramedics, between 3.4 and 33.7 per 100,000 for firefighter--EMTs, and up to 3.6 per 100,000 for firefighters (non-EMT). Conclusions. This review suggests there are a limited number of studies ad-dressing this issue, and these studies have numerous limitations. Despite the expected occupational seroconversions and recognizing the limitations in drawing conclusions from these studies, it appears that firefighters and EMS personnel do not have an elevated seroprevalence of hepatitis C virus compared with the general population. Improved exposure surveillance programs would clarify exposure risks and identify potential interventions for firefighters and EMS personnel.
SN - 1090-3127
AD - Surveillance Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226; wboal2cdc.gov
U2 - PMID: 16036853.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106507940&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bailer, A. John
AU - Noble, Robert B.
AU - Wheeler, Matthew W.
T1 - Model Uncertainty and Risk Estimation for Experimental Studies of Quantal Responses.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2005/04//
VL - 25
IS - 2
M3 - Article
SP - 291
EP - 299
PB - Wiley-Blackwell
SN - 02724332
AB - Experimental animal studies often serve as the basis for predicting risk of adverse responses in humans exposed to occupational hazards. A statistical model is applied to exposure-response data and this fitted model may be used to obtain estimates of the exposure associated with a specified level of adverse response. Unfortunately, a number of different statistical models are candidates for fitting the data and may result in wide ranging estimates of risk. Bayesian model averaging (BMA) offers a strategy for addressing uncertainty in the selection of statistical models when generating risk estimates. This strategy is illustrated with two examples: applying the multistage model to cancer responses and a second example where different quantal models are fit to kidney lesion data. BMA provides excess risk estimates or benchmark dose estimates that reflects model uncertainty. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Risk assessment
KW - Laboratory animals
KW - Bayesian analysis
KW - Uncertainty
KW - Bayesian model averaging
KW - benchmark doses
KW - quantal multistage models
KW - unit cancer risk
N1 - Accession Number: 16925834; Bailer, A. John 1; Email Address: baileraj@muohio.edu; Noble, Robert B. 1; Wheeler, Matthew W. 2; Affiliations: 1: Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA; 2: Risk Evaluation Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45224, USA; Issue Info: Apr2005, Vol. 25 Issue 2, p291; Thesaurus Term: Health risk assessment; Thesaurus Term: Risk assessment; Subject Term: Laboratory animals; Subject Term: Bayesian analysis; Subject Term: Uncertainty; Author-Supplied Keyword: Bayesian model averaging; Author-Supplied Keyword: benchmark doses; Author-Supplied Keyword: quantal multistage models; Author-Supplied Keyword: unit cancer risk; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 9p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1539-6924.2005.00590.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16925834&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Simms, Ian
AU - Fenton, Kevin A.
AU - Ashton, Matthew
AU - Turner, Katherine M.E.
AU - Crawley-Boevey, Emma E.
AU - Gorton, Russell
AU - Thomas, Daniel RH.
AU - Lynch, Audrey
AU - Winter, Andrew
AU - Fisher, Martin J.
AU - Lighton, Lorraine
AU - Maguire, Helen C.
AU - Solomou, Maria
T1 - The Re-Emergence of Syphilis in the United Kingdom: The New Epidemic Phases.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2005/04//
VL - 32
IS - 4
M3 - Article
SP - 220
EP - 226
SN - 01485717
AB - Objective: The objective of this study was to characterize the resurgence of infectious syphilis in the United Kingdom between 1997 and 2003. Study: The authors conducted a retrospective analysis of routine surveillance data from genitourinary medicine clinics and data collected through enhanced surveillance. Results: Between 1997 and 2002, diagnoses of primary, secondary, and early latent syphilis made at genitourinary medicine clinics in- creased by 213% in heterosexual males, 1412% in men who have sex with men (MSM), and 22% in females, These increases have been driven by a series of outbreaks, the largest of which were seen in Manchester (528) and London (1222) up to the end of October 2003. All the outbreaks have been geographically localized and the majority of cases occurred in MSM. A high percentage of concurrent HIV infection was reported, and oral sex was often reported as a route of transmission. Conclusions: Syphilis has reemerged in response to behavior change, probably driven by changes in the HIV epidemic. The future course of the epidemic is difficult to predict and control remains elusive. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Diseases is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYPHILIS
KW - SEXUALLY transmitted diseases
KW - TREPONEMATOSES
KW - DISEASES
KW - EPIDEMICS
KW - GREAT Britain
N1 - Accession Number: 16632517; Simms, Ian 1; Email Address: ian.simms@hpa.org.uk Fenton, Kevin A. 2 Ashton, Matthew 3 Turner, Katherine M.E. 1 Crawley-Boevey, Emma E. 4 Gorton, Russell 5 Thomas, Daniel RH. 6 Lynch, Audrey 7 Winter, Andrew 8 Fisher, Martin J. 9 Lighton, Lorraine 10 Maguire, Helen C. 4 Solomou, Maria 4; Affiliation: 1: Health Protection Agency Communicable Disease Surveillance Centre, London, U.K. 2: HIV & STI Department, Health Protection Agency Communicable Disease Surveillance Centre, London, U.K. 3: Health Protection Agency North West, Liverpool, U.K. 4: Health Protection Agency, London, U.K. 5: Health Protection Agency North East, Newcastle-Upon-Tyne, U.K. 6: National Public Health Service for Wales Communicable Disease Surveillance Centre, Cardiff, Wales 7: CDSC Northern Ireland, Belfast, Northern Ireland 8: HIV and Genitourinary Medicine, Sandyford Initiative, Glasgow, Scotland 9: HIV and Genitourinary Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, U.K. 10: Greater Manchester Syphilis Group, Manchester, U.K.; Source Info: Apr2005, Vol. 32 Issue 4, p220; Subject Term: SYPHILIS; Subject Term: SEXUALLY transmitted diseases; Subject Term: TREPONEMATOSES; Subject Term: DISEASES; Subject Term: EPIDEMICS; Subject Term: GREAT Britain; Number of Pages: 7p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1097/01.olq.0000149848.03733.c1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16632517&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ryu, Gyu Ha
AU - Yang, Won-Sun
AU - Roh, Hye-Won
AU - Lee, In-Seop
AU - Kim, Jeong Koo
AU - Lee, Gun Hwan
AU - Lee, Dong Hee
AU - Park, Bong Joo
AU - Lee, Min Sub
AU - Park, Jong-Chul
T1 - Plasma surface modification of poly (d,l-lactic-co-glycolic acid) (65/35) film for tissue engineering
JO - Surface & Coatings Technology
JF - Surface & Coatings Technology
Y1 - 2005/04//
VL - 193
IS - 1-3
M3 - Article
SP - 60
EP - 64
SN - 02578972
AB - Abstract: Plasma technique can easily be used to introduce desired functional groups or chains onto the surface of materials, so it has a special application to improve the cell affinity of scaffolds. Additionally, it has been demonstrated that plasma treatment is a unique and powerful method for modifying polymeric materials without altering their bulk properties. Cell affinity is the most important factor to be considered when biodegradable polymeric materials such as poly (d,l-lactic-co-glycolic acid) (PLGA) are utilized as a cell scaffold in tissue engineering. In this study, PLGA surface was modified with TiO2 using magnetron sputtering in order to improve PLGA surface/cells interaction. The changes of surface properties have been characterized by contact angle measurement and X-ray photoelectron spectroscopy (XPS). To confirm the attachment or proliferation of human dermal fibroblasts and rat cortical neural cells, MTT assay and scanning electron microscopy (SEM) were carried out. The results indicated that TiO2-coated PLGA film became hydrophilic and enhanced cell affinity and/or proliferation. It has been suggested that TiO2-coated PLGA matrix can be a candidate for cell scaffolds in tissue engineering. [Copyright &y& Elsevier]
AB - Copyright of Surface & Coatings Technology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUE engineering
KW - BIOMEDICAL engineering
KW - PHOTOELECTRON spectroscopy
KW - SURFACE chemistry
KW - Human dermal fibroblast
KW - Plasma treatment
KW - PLGA film
KW - Rat cortical neural cell
KW - Tissue engineering
N1 - Accession Number: 16393437; Ryu, Gyu Ha 1 Yang, Won-Sun 1,2 Roh, Hye-Won 1 Lee, In-Seop 3 Kim, Jeong Koo 4 Lee, Gun Hwan 5 Lee, Dong Hee 2 Park, Bong Joo 2 Lee, Min Sub 2 Park, Jong-Chul 2,6; Email Address: parkjc@yumc.yonsei.ac.kr; Affiliation: 1: Department of Medical Devices and Radiation Health, Korea Food and Drug administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Republic of Korea 2: Department of Medical Engineering, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul 120-752, Republic of Korea 3: Atomic-scale surface science research center, Yonsei University, 134 Shinchon-dong, Seodaemun-ku, Seoul 120-749, Republic of Korea 4: Department of Biomedical Engineering, College of Biomedical Science and Engineering, Inje University, Kimhae 621-749, Republic of Korea 5: Korea Institute of Machinery and Materials, Chang-Won 641-010, Republic of Korea 6: Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun ku Seoul 120-752, Republic of Korea; Source Info: Apr2005, Vol. 193 Issue 1-3, p60; Subject Term: TISSUE engineering; Subject Term: BIOMEDICAL engineering; Subject Term: PHOTOELECTRON spectroscopy; Subject Term: SURFACE chemistry; Author-Supplied Keyword: Human dermal fibroblast; Author-Supplied Keyword: Plasma treatment; Author-Supplied Keyword: PLGA film; Author-Supplied Keyword: Rat cortical neural cell; Author-Supplied Keyword: Tissue engineering; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.surfcoat.2004.07.062
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16393437&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Epstein, Jay S.
T1 - Insights on donor screening for West Nile virus.
JO - Transfusion
JF - Transfusion
Y1 - 2005/04//
VL - 45
IS - 4
M3 - Editorial
SP - 460
EP - 462
PB - Wiley-Blackwell
SN - 00411132
AB - Comments on the articles published in the journal, documenting the outcome and limitations of interventions to prevent transmission of West Nile virus (WNV) by transfusion. Evaluation of the follow-up testing of donors with reactive screening tests which allowed the performance of WNV screening; Assessment and comparison of the sensitivities of the nucleic acid test (NAT) screening and additional assays; Increase in analytical sensitivity of NAT system for WNV.
KW - WEST Nile virus
KW - VIRUS diseases
KW - COMMUNICABLE diseases -- Transmission
KW - BLOOD transfusion
KW - BLOOD donors
N1 - Accession Number: 16466488; Epstein, Jay S. 1; Email Address: epsteinj@cber.FDA.gov; Affiliation: 1: Office of Blood Research and Review, Food and Drug Administration, HFM-300, 1401 Rockville Pike, Rockville, MD 20852-1448; Source Info: Apr2005, Vol. 45 Issue 4, p460; Subject Term: WEST Nile virus; Subject Term: VIRUS diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: BLOOD transfusion; Subject Term: BLOOD donors; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1111/j.0041-1132.2005.45041.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16466488&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-04327-003
AN - 2005-04327-003
AU - Larson, Mary Jo
AU - Miller, Lisa
AU - Becker, Marion
AU - Richardson, Erin
AU - Kammerer, Nina
AU - Thom, Jennifer
AU - Gampel, Joanne
AU - Savage, Andrea
T1 - Physical Health Burdens of Women With Trauma Histories and Co-occurring Substance Abuse and Mental Disorders.
T3 - The Impact of Co-occurring Disorders and Violence on Women
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2005/04//Apr-Jun, 2005
VL - 32
IS - 2
SP - 128
EP - 140
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Larson, Mary Jo, New England Research Institutes Inc, 9 Galen St, Watertown, MA, US, 02472
N1 - Accession Number: 2005-04327-003. PMID: 15834263 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Larson, Mary Jo; New England Research Institutes Inc, Watertown, MA, US. Other Publishers: Springer. Release Date: 20050613. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Emotional Trauma; Health Complaints; Mental Disorders. Minor Descriptor: Health; Physical Abuse; Physical Health; Sexual Abuse. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Apr-Jun, 2005.
AB - This article documents the physical health burdens of participants in a large, federally funded cross-site study of specialized services for women with histories of trauma (physical or sexual abuse) and co-occurring substance abuse and mental health disorders. Nearly half of the 2729 women in the study (48%) reported serious physical illnesses that frequently limited their daily life activities or required them to use special equipment. Nearly half (46%) rated their health status as only fair or poor. Given the prevalence of physical illnesses in this population, behavioral service providers should discuss with clients their overall health and how it might hinder their participation in treatment for trauma, substance abuse, and mental illness, and policymakers should consider this need when designing behavioral health requirements, setting reimbursement rates, and allocating funds. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - co-occurring disorders
KW - women
KW - substance abuse
KW - mental disorders
KW - physical health burdens
KW - trauma history
KW - physical abuse
KW - sexual abuse
KW - 2005
KW - Comorbidity
KW - Drug Abuse
KW - Emotional Trauma
KW - Health Complaints
KW - Mental Disorders
KW - Health
KW - Physical Abuse
KW - Physical Health
KW - Sexual Abuse
KW - 2005
DO - 10.1007/BF02287262
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04327-003&site=ehost-live&scope=site
UR - mjlarson@neri.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04929-004
AN - 2005-04929-004
AU - Chambers, David A.
AU - Pearson, Jane L.
AU - Lubell, Keri
AU - Brandon, Susan
AU - O'Brien, Kevin
AU - Zinn, Janet
T1 - The Science of Public Messages for Suicide Prevention: A Workshop Summary.
JF - Suicide and Life-Threatening Behavior
JO - Suicide and Life-Threatening Behavior
JA - Suicide Life Threat Behav
Y1 - 2005/04//
VL - 35
IS - 2
SP - 134
EP - 145
CY - US
PB - Guilford Publications
SN - 0363-0234
SN - 1943-278X
AD - Chambers, David A., Dissemination and Implementation Program, National Institute of Mental Health, 6001 Executive Blvd., Rm. 7133, MSC 9631, Bethesda, MD, US, 20892-9631
N1 - Accession Number: 2005-04929-004. PMID: 15843331 Other Journal Title: Life-Threatening Behavior; Suicide. Partial author list: First Author & Affiliation: Chambers, David A.; National Institute of Mental Health, Bethesda, MD, US. Other Publishers: Behavioral Publications; Human Sciences Press, Inc.; Wiley-Blackwell Publishing Ltd. Release Date: 20050531. Correction Date: 20130610. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Messages; Public Health; Suicide Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. References Available: Y. Page Count: 12. Issue Publication Date: Apr, 2005.
AB - There is minimal guidance for efforts to create effective public messages that increase awareness that suicide is preventable. To address this need, several agencies in the U.S. Department of Health and Human Services and the Annenberg Foundation convened a workshop consisting of suicide prevention advocates and persons with expertise in public health evaluation, suicide contagion, decision-making, and marketing. 'Logic models' were used to define intended messages and audiences, assumed mechanisms of change, and outcomes. This summary describes some of the challenges and opportunities identified by workshop participants in evaluating public awareness campaigns in suicide prevention, technical assistance needs, and a proposed research agenda. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public messages
KW - suicide prevention
KW - public health
KW - 2005
KW - Messages
KW - Public Health
KW - Suicide Prevention
KW - 2005
DO - 10.1521/suli.35.2.134.62871
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04929-004&site=ehost-live&scope=site
UR - dchamber@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10582-002
AN - 2006-10582-002
AU - Newman, Sara B.
AU - Nelson, Michael B.
AU - Friedman, Heidi B.
AU - Gaydos, Charlotte A.
T1 - Should Female Federal Inmates Be Screened for Chlamydial and Gonococcal Infection?
JF - Journal of Correctional Health Care
JO - Journal of Correctional Health Care
JA - J Correct Health Care
Y1 - 2005/04//
VL - 11
IS - 2
SP - 137
EP - 155
CY - US
PB - Sage Publications
SN - 1078-3458
SN - 1940-5200
AD - Newman, Sara B., 10 N. Fillmore St., Arlington, VA, US, 22201
N1 - Accession Number: 2006-10582-002. Partial author list: First Author & Affiliation: Newman, Sara B.; U.S. Public Health Service, Division of Immigration Health Services, Washington, DC, US. Release Date: 20070305. Correction Date: 20111107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Gonorrhea; Human Females; Prisoners; Screening; Sexually Transmitted Diseases. Minor Descriptor: Prisons. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Apr, 2005.
AB - The study was implemented to assist the Federal Bureau of Prisons (BOP) in designing a rational chlamydial and gonococcal screening protocol for female inmates based on prevalence of infection. Surveys were administered and urine and swab specimens collected from study participants. At the prison where women were screened at entry, 1.2% tested positive for CT and 0.3% tested positive for GC. At the prison where women were not screened, 2.3% were positive for CT; no GC cases were identified. At this site, young age (18-22 years) was the most important factor associated with infection (RR 6.4), where a prevalence of 8.5% was found. Prevalence among women age 30 and younger exceeded 3.5%. Screening women age 30 and younger would identify more than 60% of cases at an estimated cost of less than $60,000 per year at this site. It is recommended that women 30 years of age and younger be screened at intake for chlamydial infection at federal prisons. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chlamydial infection
KW - gonococcal infection
KW - screening
KW - Federal Bureau of Prisons
KW - female inmates
KW - 2005
KW - Gonorrhea
KW - Human Females
KW - Prisoners
KW - Screening
KW - Sexually Transmitted Diseases
KW - Prisons
KW - 2005
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: Federal Bureau of Prisons. Recipients: No recipient indicated
U1 - Sponsor: Uniformed Services University of the Health Sciences. Recipients: No recipient indicated
DO - 10.1177/107834580401100203
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10582-002&site=ehost-live&scope=site
UR - sara.newman@dhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04327-004
AN - 2005-04327-004
AU - Finkelstein, Norma
AU - Rechberger, Elke
AU - Russell, Lisa A.
AU - VanDeMark, Nancy R.
AU - Noether, Chanson D.
AU - O'Keefe, Maura
AU - Gould, Karen
AU - Mockus, Susan
AU - Rael, Melissa
T1 - Building Resilience in Children of Mothers Who Have Co-occurring Disorders and Histories of Violence: Intervention Model and Implementation Issues.
T3 - The Impact of Co-occurring Disorders and Violence on Women
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2005/04//Apr-Jun, 2005
VL - 32
IS - 2
SP - 141
EP - 154
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Finkelstein, Norma, Institute for Health and Recovery, 349 Broadway, Cambridge, MA, US, 02139
N1 - Accession Number: 2005-04327-004. PMID: 15834264 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Finkelstein, Norma; Institute for Health and Recovery, Cambridge, MA, US. Other Publishers: Springer. Release Date: 20050613. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Mental Disorders; Offspring; Resilience (Psychological); Violence. Minor Descriptor: Advocacy; Comorbidity; Group Psychotherapy; Health Care Psychology; Mothers. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Tests & Measures: Behavioral and Emotional Rating Scale; Child Behavior Checklist. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Apr-Jun, 2005.
AB - Historically, children of parents with co-occurring substance abuse and mental health disorders and histories of violence/trauma have been overlooked in behavioral health treatment systems. The Women, Co-occurring Disorders and Violence Study (WCDVS) was a 5-year initiative funded by the United States Substance Abuse and Mental Health Services Administration (SAMHSA) that included a Children's Study that explored the treatment needs of children of women with these multiple disorders. This article describes the development of the Children's Study intervention that included clinical assessment, group intervention, and resource coordination/advocacy for children aged 5-10 to build resilience through increasing coping skills, improving interpersonal relationships, and helping coalesce positive identity and self-esteem. Innovative procedures, including the participation of consumer/survivor/recovering women and mothers, in the planning, implementation, and administrative applications of this intervention and study are also highlighted. It is recommended that programs begin to implement family-focused integrated treatment approaches that can potentially increase protective factors for children affected by parental mental illness, substance abuse, and violence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - resilience
KW - children
KW - mothers
KW - mental disorders
KW - substance abuse disorders
KW - violence
KW - behavioral health treatment
KW - clinical assessment
KW - group intervention
KW - resource coordination
KW - advocacy
KW - 2005
KW - Drug Abuse
KW - Mental Disorders
KW - Offspring
KW - Resilience (Psychological)
KW - Violence
KW - Advocacy
KW - Comorbidity
KW - Group Psychotherapy
KW - Health Care Psychology
KW - Mothers
KW - 2005
DO - 10.1007/BF02287263
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04327-004&site=ehost-live&scope=site
UR - normafinkelstein@healthrecovery.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03810-006
AN - 2005-03810-006
AU - Geller, Jeffrey L.
AU - Shore, Helen
AU - Grudzinskas, Albert J. Jr.
AU - Appelbaum, Paul S.
T1 - Against the Grain? A Reasoned Argument for not Closing a State Hospital.
JF - Psychiatric Quarterly
JO - Psychiatric Quarterly
JA - Psychiatr Q
Y1 - 2005/04//
VL - 76
IS - 2
SP - 177
EP - 194
CY - Germany
PB - Springer
SN - 0033-2720
SN - 1573-6709
AD - Geller, Jeffrey L., UMass Medical School, Department of Psychiatry, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2005-03810-006. PMID: 15884744 Partial author list: First Author & Affiliation: Geller, Jeffrey L.; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20050502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; Psychiatric Hospitals; Psychiatry. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. References Available: Y. Page Count: 18. Issue Publication Date: Apr, 2005.
AB - In the face of the Massachusetts Governor's attempts to close one of the state's four remaining state hospitals, Massachusetts legislators overrode the Governor's veto of funding for the hospital, but required the state's Mental Health Authority to author a study of the implications of further loss of public sector inpatient beds. The Center for Mental Health Services Research of the University of Massachusetts Medical School conducted its own study concluding that maintaining a longer-term inpatient capacity in the public sector in central Massachusetts was both necessary and accrued a significant number of benefits. This article can serve as a model for the reasoned position that a state hospital in 21st century psychiatry can be looked at as a multiservice center that fulfills a key role in a public sector, integrated system of treatment, care, training and research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state hospital
KW - mental health services
KW - inpatient capacity
KW - psychiatry
KW - 2005
KW - Mental Health Services
KW - Psychiatric Hospitals
KW - Psychiatry
KW - 2005
DO - 10.1007/s11089-005-2338-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03810-006&site=ehost-live&scope=site
UR - Jeffrey.geller@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04503-002
AN - 2005-04503-002
AU - Ann Ottinger, Mary
AU - Wu, Julie M.
AU - Hazelton, Julie L.
AU - Abdelnabi, Mahmoud A.
AU - Thompson, Nichola
AU - Quinn, Michael L. Jr.
AU - Donoghue, Dan
AU - Schenck, Frank
AU - Ruscio, Michael
AU - Beavers, Joanne
AU - Jaber, Mark
T1 - Assessing the consequences of the pesticide methoxychlor: Neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical.
T3 - Action of Environmental Estrogens on Neural Circuits and Behavior
JF - Brain Research Bulletin
JO - Brain Research Bulletin
JA - Brain Res Bull
Y1 - 2005/04//
VL - 65
IS - 3
SP - 199
EP - 209
CY - Netherlands
PB - Elsevier Science
SN - 0361-9230
SN - 1873-2747
AD - Ann Ottinger, Mary, Department of Animal and Avian Sciences, University of Maryland, College Park, MD, US, 20742
N1 - Accession Number: 2005-04503-002. PMID: 15811582 Partial author list: First Author & Affiliation: Ann Ottinger, Mary; Department of Animal and Avian Sciences, University of Maryland, College Park, MD, US. Release Date: 20050627. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Chemicals; Environmental Effects; Insecticides; Prenatal Exposure; Quails. Minor Descriptor: Animal Ethology; Estrogens; Neuroendocrinology; Consequence. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Apr, 2005.
AB - Japanese quail provide an advantageous avian model for assessing long-term biological consequences of endocrine disrupting chemicals (EDCs). These studies examined route of exposure and vulnerability to biological impact of EDCs over the life cycle in a precocial avian model, the Japanese quail. Embryonic exposure occurs with maternal deposition and methoxychlor (MXC) accumulated with maternal exposure. Egg injections of MXC or estradiol at selected stages of development impacted hypothalamic neuroendocrine systems in hatchlings and affected sexual maturation, with evidence for long-term effects on neurotransmitters and male behavior. Two-generation dietary studies were conducted to examine transgenerational effects of EDCs. Adult quail (P1) were exposed to dietary MXC (0, 0.5 and 5 ppm), with continued exposure in their offspring (F1), and control diet for all F2 chicks. Toxicological end points, including fertility, hatching success, and 14-day viability were unaffected. F1 and F2 male offspring from MXC-treated pairs MXC had impaired mating behavior and altered plasma hormones. These studies confirm neuroendocrine and behavioral measures as reliable indices of exposure to an estrogenic EDC. Moreover, maternal deposition remains a primary route of EDC exposure, with potential deleterious consequences for field birds, especially precocial species that appear to be particularly sensitive to embryonic EDC exposure. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - pesticide
KW - biological impact
KW - estrogenic environmental chemical
KW - methoxychlor
KW - embryonic exposure
KW - maternal deposition
KW - quail
KW - neuroendocrine & behavioral measures
KW - 2005
KW - Chemicals
KW - Environmental Effects
KW - Insecticides
KW - Prenatal Exposure
KW - Quails
KW - Animal Ethology
KW - Estrogens
KW - Neuroendocrinology
KW - Consequence
KW - 2005
DO - 10.1016/j.brainresbull.2004.11.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04503-002&site=ehost-live&scope=site
UR - maotting@umd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-02361-007
AN - 2005-02361-007
AU - DiGirolamo, Ann
AU - Thompson, Nancy
AU - Martorell, Reynaldo
AU - Fein, Sara
AU - Grummer-Strawn, Laurence
T1 - Intention or Experience? Predictors of Continued Breastfeeding.
JF - Health Education & Behavior
JO - Health Education & Behavior
JA - Health Educ Behav
Y1 - 2005/04//
VL - 32
IS - 2
SP - 208
EP - 226
CY - US
PB - Sage Publications
SN - 1090-1981
SN - 1552-6127
AD - DiGirolamo, Ann, Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd., NE, Atlanta, GA, US, 30322
N1 - Accession Number: 2005-02361-007. PMID: 15749967 Other Journal Title: Health Education Monographs; Health Education Quarterly. Partial author list: First Author & Affiliation: DiGirolamo, Ann; Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, US. Release Date: 20050321. Correction Date: 20110725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Demographic Characteristics; Intention. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Apr, 2005.
AB - Despite the known benefits of breastfeeding, many women do not breastfeed their infants or stop breastfeeding early. This study examines the effects of prenatal intention and initial breastfeeding experiences on breastfeeding initiation and duration among 1,665 U.S. women completing questionnaires on infant feeding practices. Outcomes included no initiation of breastfeeding at birth and termination at < 10 weeks, 10 to < 20 weeks, or 20 to < 30 weeks. Predictor variables included intended breastfeeding duration and early breastfeeding experiences with analyses controlling for demographic characteristics, previous breastfeeding experience, and prenatal intentions to work after delivery. Prenatal intentions to never initiate or to stop breastfeeding early were significant risk factors for all breastfeeding outcomes. Initial breastfeeding experiences were significant risk factors for early termination. This study supports using the intention construct from the theory of reasoned action to predict initiation of behavior but suggests the need to include initial experience when predicting maintenance of behavior. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant feeding practices
KW - prenatal intention
KW - initial breastfeeding experiences
KW - demographic characteristics
KW - intentions to work
KW - 2005
KW - Breast Feeding
KW - Demographic Characteristics
KW - Intention
KW - 2005
DO - 10.1177/1090198104271971
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-02361-007&site=ehost-live&scope=site
UR - adigiro@sph.emory.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04633-003
AN - 2005-04633-003
AU - Wegienka, Ganesa
AU - Baird, Donna Day
T1 - A Comparison of Recalled Date of Last Menstrual Period with Prospectively Recorded Dates.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2005/04//
VL - 14
IS - 3
SP - 248
EP - 252
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Wegienka, Ganesa, Department of Biostatistics and Research Epidemiology, 1 Ford Place, 3E, Detroit, MI, US, 48202
N1 - Accession Number: 2005-04633-003. PMID: 15857271 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Wegienka, Ganesa; Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI, US. Release Date: 20050620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Menstruation; Recall (Learning). Classification: Physiological Processes (2540). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2005.
AB - Background: Women are often asked to recall the first day of their last menstrual period (LMP date) in a clinic setting (i.e., pregnancy dating, x-rays). There are no data supporting the validity of these reports. Methods: Using data from a group of 385 women ages 35-49 from a larger cohort study in the Washington, DC, area, we constructed menstrual segments from a prospective daily menstrual record. We then compared the first day of a menstrual segment to a woman's recalled LMP date at a subsequent study-related clinic appointment to assess the accuracy of recall. Results: More than half of the women (56%) accurately recalled their LMP date; 74% were within 1 day, and 81% were within 2 days. Women tended to underreport (25%) the length of time since their last menstrual period rather than overreport the length of time (19%). Recall accuracy did not vary significantly with education or by whether the woman usually recorded her menstrual cycle when not in the study. As one might expect, women with a shorter recall duration tended to report more accurately. Discussion: Women appear to recall their LMP dates fairly accurately, but inaccurate recall was not random. When length of recall was 3 weeks or longer, women tended to overestimate the time since LMP. This suggests that gestational age calculated from LMP date will tend to be overestimated. Most women can recall the date of their LMP reasonably well regardless of their education and whether they usually record their LMP dates. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recall date
KW - last menstrual period
KW - recall duration
KW - dates
KW - 2005
KW - Human Females
KW - Menstruation
KW - Recall (Learning)
KW - 2005
DO - 10.1089/jwh.2005.14.248
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04633-003&site=ehost-live&scope=site
UR - gwegien1@hfhs.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-03505-003
AN - 2005-03505-003
AU - Lamerz, A.
AU - Kuepper-Nybelen, J.
AU - Wehle, C.
AU - Bruning, N.
AU - Trost-Brinkhues, G.
AU - Brenner, H.
AU - Hebebrand, J.
AU - Herpertz-Dahlmann, B.
T1 - Social class, parental education, and obesity prevalence in a study of six-year-old children in Germany.
JF - International Journal of Obesity
JO - International Journal of Obesity
JA - Int J Obes (Lond)
Y1 - 2005/04//
VL - 29
IS - 4
SP - 373
EP - 380
CY - United Kingdom
PB - Nature Publishing Group
SN - 0307-0565
SN - 1476-5497
AD - Lamerz, A., University Hospital Aachen, Department of Child and Adolescent Psychiatry, Neuenhofer Weg 21, D-52074, Aachen, Germany
N1 - Accession Number: 2005-03505-003. PMID: 15768043 Partial author list: First Author & Affiliation: Lamerz, A.; Department of Child and Adolescent Psychiatry, University Hospital Aachen, Aachen, Germany. Release Date: 20050516. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Obesity; Parent Educational Background; Social Class. Minor Descriptor: At Risk Populations; Socioeconomic Status. Classification: Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: Germany. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2005.
AB - Objective: To assess the association between socioeconomic status (SES) and childhood obesity, and which factor in particular stands out in relation to obesity. Methods: When 2020 children attended their obligatory health exam prior to school entry in the City of Aachen, Germany, 1979 parents (97.9%) filled out a questionnaire on their child's weight development and on indicators of their family's SES in a cross-sectional survey. In addition, standardized measures of weight and height were taken. More detailed information on several different SES variables, such as parental education, occupation, income, family constellation, single parenthood, and the location and size of the family speaking children with a BMI ≥ 85th percentile, defined as cases (n = 146), and with residence was obtained by personal interviews in a subsample of all native German a BMI between the 40th and 60th percentile, defined as controls (n = 221). Results: The indicators of parental education were most strongly associated with children's obesity. There was a strong dose-response relationship between a composed index of social class and obesity. Children of the lowest social status had a more than three-fold risk to be obese than children of the highest social status in the screening population (OR: 3.29, CI: 1.92-5.63). Conclusions: The findings established a strong relationship between parental years of education and childhood obesity. Prevention and treatment programs should endeavor to better target undereducated parents and their young children at high risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental education
KW - socioeconomic status
KW - childhood obesity
KW - prevalence
KW - social class
KW - 2005
KW - Epidemiology
KW - Obesity
KW - Parent Educational Background
KW - Social Class
KW - At Risk Populations
KW - Socioeconomic Status
KW - 2005
DO - 10.1038/sj.ijo.0802914
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03505-003&site=ehost-live&scope=site
UR - alamerz@ukaachen.de
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10895-005
AN - 2006-10895-005
AU - Phillips, Charles D.
AU - Holan, Scott
AU - Sherman, Michael
AU - Spector, William
AU - Hawes, Catherine
T1 - Medicare Expenditures for Residents in Assisted Living: Data from a National Study.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2005/04//
VL - 40
IS - 2
SP - 373
EP - 388
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Phillips, Charles D., School of Rural Public Health, Texas A&M University System of Health Science Center, 3000 Briarcrest Drive, Suite 310, Bryan, TX, US, 77803
N1 - Accession Number: 2006-10895-005. PMID: 15762897 Partial author list: First Author & Affiliation: Phillips, Charles D.; School of Rural Public Health, Texas A&M University System of Health Science Center, Bryan, TX, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070319. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Phillips, Charles D. Major Descriptor: Assisted Living; Health Care Costs; Health Care Utilization; Medicare. Minor Descriptor: Long Term Care; Residential Care Institutions. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Apr, 2005.
AB - Objective: To provide preliminary data on Medicare expenditures for assisted living facility (ALF) residents and to investigate whether ALF characteristics were related to Medicare expenditures for ALF residents. Data Sources/Study Setting: Data from the National Study of Assisted Living for the Frail Elderly conducted in 1998-1999. This analysis was restricted to the 40 percent of ALFs in that sample that adhered to the assisted living (AL) philosophy by offering more than minimal levels of services and privacy. This study involved the approximately 1,200 residents who remained in an ALF from baseline to follow-up data collection. Six months of postbaseline Medicare claims were acquired for 54.5 of these residents, who did not differ significantly from the larger sample. Data Collection: Baseline individual and facility data were collected in personal interviews with residents and a combination of personal and telephone interviews with facility staff. Medicare claims data were acquired from the Centers for Medicare and Medicaid Services. Study Design: Cross-sectional analyses using logistic and ordinary least squares regression techniques were used to determine the relationships among individual and facility characteristics and Medicare utilization and expenditures. Principal Findings: On an annualized basis, AL residents incurred Medicare costs of approximately $4,800. Just less than 15 percent of AL residents accounted for over 75 percent of total Medicare costs. Both the likelihood of utilizing Medicare-covered services and the intensity of service use were largely unaffected by the characteristics of the ALF in which residents lived. Utilization was largely a function of individual characteristics. The only exception to this general finding was that those individuals who utilized services and resided in smaller ALFs had significantly lower average expenditures than did individuals in larger ALFs. Conclusions: These preliminary data imply that both the level and distribution of Medicare expenditures among ALF residents were similar to those among the general community-dwelling Medicare beneficiary population. No significant relationships were observed between ALF characteristics and Medicare expenditures, except the effect of facility size. This result may imply that how the AL industry eventually defines itself in terms of services and amenities, other than size, may have little impact on Medicare expenditures for ALF residents. However, this is a single, initial study, so caution must be exercised when considering the implications of these results. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Medicare expenditures
KW - assisted living facility residents
KW - health care utilization
KW - long term care
KW - 2005
KW - Assisted Living
KW - Health Care Costs
KW - Health Care Utilization
KW - Medicare
KW - Long Term Care
KW - Residential Care Institutions
KW - 2005
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: RO1-HS-10606. Recipients: Phillips, Charles D. (Prin Inv)
U1 - Sponsor: US Department of Health and Human Services, Office of the Assistant Secretary for Planning and Evaluation (ASPE), Office of Disability, Aging, and Long-Term Care Policy, US. Grant: HHS-100-94-0024; HHS-100-98-0013. Recipients: No recipient indicated
DO - 10.1111/j.1475-6773.2005.0s363.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10895-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-02953-006
AN - 2005-02953-006
AU - Lamerz, Andreas
AU - Kuepper-Nybelen, Jutta
AU - Bruning, Nicole
AU - Wehle, Christine
AU - Trost-Brinkhues, Gabriele
AU - Brenner, Hermann
AU - Hebebrand, Johannes
AU - Herpertz-Dahlmann, Beate
T1 - Prevalence of obesity, binge eating, and night eating in a cross-sectional field survey of 6-year-old children and their parents in a German urban population.
JF - Journal of Child Psychology and Psychiatry
JO - Journal of Child Psychology and Psychiatry
JA - J Child Psychol Psychiatry
Y1 - 2005/04//
VL - 46
IS - 4
SP - 385
EP - 393
CY - United Kingdom
PB - Blackwell Publishing
SN - 0021-9630
SN - 1469-7610
AD - Lamerz, Andreas, University Hospital of the Technical, University of Aachen, Department of Child and Adolescent Psychiatry, Neuenhofer Weg 21, D-52074, Aachen, Germany
N1 - Accession Number: 2005-02953-006. PMID: 15819647 Other Journal Title: Child Psychology & Psychiatry & Allied Disciplines. Partial author list: First Author & Affiliation: Lamerz, Andreas; Department of Child and Adolescent Psychiatry, Technical University of Aachen, Aachen, Germany. Other Publishers: Cambridge University Press; Elsevier Science; Pergamon Press; Wiley-Blackwell Publishing Ltd. Release Date: 20050502. Correction Date: 20130527. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Binge Eating; Eating Disorders; Family Background; Obesity. Minor Descriptor: Parents. Classification: Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: Germany. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 2005.
AB - Background: To assess the prevalence of obesity, obesity-related binge eating, non-obesity-related binge eating, and night eating in five- to six-year-old children and to examine the impact of parental eating disturbances. Methods: When 2,020 children attended their obligatory health exam prior to school entry in the city of Aachen, Germany, 1,979 parents (97.9%) filled out a questionnaire on their child's eating habits and weight development in a cross-sectional survey. Anthropometric measurements were collected for all children in a standardized form. Results: Episodes of binge eating were found in 2.0% of the children surveyed and night eating in 1.1%. There was a significant relationship between binge eating and obesity but not between night eating and the child's weight. Children's binge eating and night eating were strongly associated with eating disturbances on the part of their mothers (adjusted odds ratios [95% confidence intervals]: 6.1 [2.7-13.5] and 7.8 [2.1-29.4], respectively) and with a non-German native language (adjusted odds ratios [95% confidence intervals]: 2.6 [1.2-5.5] and 11.6 [3.5-38.7], respectively). Conclusions: In concurrence with studies on adulthood, binge eating is linked to obesity already in early childhood. Children of mothers with eating disorders and children of mothers with a non-German native language are at increased risk of developing eating disorders themselves. Future studies should focus on obesity and eating disorders in early childhood; prevention programs should seek to target young children at risk as early as possible. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - eating disorders
KW - obesity
KW - binge eating
KW - night eating
KW - parental eating disturbances
KW - 2005
KW - Binge Eating
KW - Eating Disorders
KW - Family Background
KW - Obesity
KW - Parents
KW - 2005
DO - 10.1111/j.1469-7610.2004.00363.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-02953-006&site=ehost-live&scope=site
UR - alamerz@ukaachen.de
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06167-012
AN - 2005-06167-012
AU - Harris, Katherine M.
AU - Larson, Sharon
AU - Edlund, Mark J.
T1 - Use of Prescription Psychiatric Drugs and Religious Service Attendance.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/04//
VL - 56
IS - 4
SP - 396
EP - 396
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Harris, Katherine M., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06167-012. PMID: 15812085 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Harris, Katherine M.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20050627. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Mental Health; Mental Health Services; Psychiatrists; Religious Practices. Minor Descriptor: Clergy; Mental Disorders. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Composite International Diagnostic Interview-Short Form; National Survey on Drug Use and Health. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 1. Issue Publication Date: Apr, 2005.
AB - Over their lifetime, persons with mental disorders seek initial treatment from clergy more frequently than from psychiatrists or general medical doctors, and a majority who seek treatment from clergy do so to the exclusion of other providers. However, little is known about the relationship between religion and use of the mental health care system. We examined the use of prescription mental health medications and religious service attendance. Persons who attend more frequently may be more likely to seek help from clergy than from mental health professionals. We focus on medications to reduce ambiguity about the religious affiliation of mental health providers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prescription psychiatric drugs
KW - religious service attendance
KW - clergy
KW - psychiatrists
KW - mental health care
KW - medication
KW - 2005
KW - Drug Therapy
KW - Mental Health
KW - Mental Health Services
KW - Psychiatrists
KW - Religious Practices
KW - Clergy
KW - Mental Disorders
KW - 2005
DO - 10.1176/appi.ps.56.4.396
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06167-012&site=ehost-live&scope=site
UR - kharris@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kim, Tae-gyun
AU - Jung, Jooyoung
AU - Mysliwiec, Matthew R.
AU - Kang, Seogyoun
AU - Lee, Youngsook
T1 - Jumonji represses α-cardiac myosin heavy chain expression via inhibiting MEF2 activity
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/04/08/
VL - 329
IS - 2
M3 - Article
SP - 544
EP - 553
SN - 0006291X
AB - Abstract: Expression of α-cardiac myosin heavy chain gene (αMHC) is developmentally regulated in normal embryonic hearts and down-regulated in cardiac myopathy and failing hearts. Jumonji (JMJ) has been shown to be critical for normal cardiovascular development and functions as a transcriptional repressor. Here, we demonstrate that JMJ represses αMHC expression through inhibition of myocyte enhancer factor 2 (MEF2) activity. In primary cardiomyocytes, overexpression of JMJ leads to marked reduction of endogenous αMHC expression. JMJ represses the synergistic activation of αMHC by MEF2 and thyroid hormone receptor (TR). Interestingly, JMJ inhibits transcriptional activities of all MEF2 isoforms, but not the TR-dependent activation. The transcriptional repression domain of JMJ interacts with the N-terminal part of MEF2A, resulting in the repression of MEF2A activities. These results suggest that JMJ represses αMHC expression via protein–protein interaction with MEF2A. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROID hormones
KW - MYOSIN
KW - CELL receptors
KW - TRANSCRIPTION factors
KW - α-Cardiac myosin heavy chain
KW - Jumonji
KW - Myocyte enhancer factor 2
KW - Transcription factor
N1 - Accession Number: 16598092; Kim, Tae-gyun 1 Jung, Jooyoung 1 Mysliwiec, Matthew R. 1 Kang, Seogyoun 2 Lee, Youngsook 1; Email Address: youngsooklee@facstaff.wisc.edu; Affiliation: 1: Department of Anatomy and Cardiovascular Research Center, University of Wisconsin Medical School, Madison, WI 53706, USA 2: Center for Biological Evaluation, Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Apr2005, Vol. 329 Issue 2, p544; Subject Term: THYROID hormones; Subject Term: MYOSIN; Subject Term: CELL receptors; Subject Term: TRANSCRIPTION factors; Author-Supplied Keyword: α-Cardiac myosin heavy chain; Author-Supplied Keyword: Jumonji; Author-Supplied Keyword: Myocyte enhancer factor 2; Author-Supplied Keyword: Transcription factor; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.01.154
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoashi, Toshihiko
AU - Watanabe, Hidenori
AU - Muller, Jacqueline
AU - Yamaguchi, Yuji
AU - Vieira, Wilfred D.
AU - Hearing, Vincent J.
T1 - MART-1 Is Required for the Function of the Melanosomal Matrix Protein PMEL17/GP100 and the Maturation of Melanosomes.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/04/08/
VL - 280
IS - 14
M3 - Article
SP - 14006
EP - 14016
SN - 00219258
AB - More than 125 genes that regulate pigmentation have been identified to date. Of those, MART-1 has been widely studied as a melanoma-specific antigen and as a melanosome-specific marker. Whereas the functions of other melanosomal proteins, such as tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, and Pmel17, are known, the function of MART-1 in melanogenesis, is unclear. A role for MART-1 in pigmentation is expected because its expression pattern and subcellular distribution is quite similar to the other melanosomal proteins and usually correlates with melanin content. We investigated the function of MART-1 using a multidisciplinary approach, including the use of siRNA to inhibit MART-1 function and the use of transfection to re-express MART-1 in MART-1-negative cells. We show that MART-1 forms a complex with Pmel17 and affects its expression, stability, trafficking, and the processing which is required for melanosome structure and maturation. We conclude that MART-1 is indispensable for Pmell7 function and thus plays an important role in regulating mammalian pigmentation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXTRACELLULAR matrix proteins
KW - PROTEINS
KW - BIOMOLECULES
KW - NEUROENDOCRINE tumors
KW - GENETIC transformation
KW - NUCLEIC acids
N1 - Accession Number: 16756927; Hoashi, Toshihiko 1 Watanabe, Hidenori 1 Muller, Jacqueline 2 Yamaguchi, Yuji Vieira, Wilfred D. 1 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892 2: Division of Viral Products, Food and Drug Administration, Rockville, Maryland 20852; Source Info: 4/8/2005, Vol. 280 Issue 14, p14006; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: PROTEINS; Subject Term: BIOMOLECULES; Subject Term: NEUROENDOCRINE tumors; Subject Term: GENETIC transformation; Subject Term: NUCLEIC acids; Number of Pages: 11p; Illustrations: 31 Color Photographs, 61 Black and White Photographs, 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1074/jbc.M413692200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Corby, R.
AU - Lanni, V.
AU - Kistler, V.
AU - Dato, V.
AU - Weltmanj, A.
AU - Yozviak, C.
AU - Waller, K.
AU - Nalluswami, K.
AU - Moll, M.
AU - Lockett, J.
AU - Montgomery, S.
AU - Lynch, M.
AU - Braden, C.
AU - DuBois, A.
T1 - Outbreaks of Salmonella Infections Associated with Eating Roma Tomatoes -- United States and Canada, 2004. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04/08/
VL - 54
IS - 13
M3 - Article
SP - 325
EP - 328
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Highlights the report on the outbreaks of Salmonella infections which is associated with eating Roma tomatoes in the U.S. and Canada in 2004. Number of culture-confirmed, outbreak associated salmonellosis that were identified in the nine states of the U.S.; Information on the traceback and environmental investigation conducted by the U.S. Food & Drug Administration; Explanation on how Salmonella can enter tomato plants.
KW - EPIDEMICS
KW - FOOD poisoning
KW - TOMATOES
KW - UNITED States
KW - CANADA
N1 - Accession Number: 16681463; Corby, R. 1 Lanni, V. 1 Kistler, V. 2 Dato, V. 3,4,5 Weltmanj, A. 3,4,5 Yozviak, C. 3,4,5 Waller, K. 3,4,5 Nalluswami, K. 3,4,5 Moll, M. 3,4,5 Lockett, J. 6 Montgomery, S. 6 Lynch, M. 6 Braden, C. 6 DuBois, A.; Affiliation: 1: Brant County Health Unit,Ontario, Canada 2: Allentown Health Bur 3: Pennsylvania Dept of Health 4: Center for Food Safety and Applied Nutrition 5: Office of Crisis Management, Food and Drug Admin. 6: Div of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, SK Gupta, MD; Source Info: 4/8/2005, Vol. 54 Issue 13, p325; Subject Term: EPIDEMICS; Subject Term: FOOD poisoning; Subject Term: TOMATOES; Subject Term: UNITED States; Subject Term: CANADA; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 4p; Illustrations: 1 Graph, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Stadel, Bruce V.
AU - Colman, Eric
AU - Sahlroot, Todd
T1 - Misleading use of risk ratios.
JO - Lancet
JF - Lancet
Y1 - 2005/04/09/
VL - 365
IS - 9467
M3 - Letter
SP - 1306
EP - 1307
PB - Lancet
SN - 00995355
AB - Presents a letter to the editor about the risk for side effects associated with prescription drugs.
KW - LETTERS to the editor
KW - DRUGS -- Side effects
N1 - Accession Number: 16693067; Stadel, Bruce V. 1; Email Address: stadel@cder.fda.gov Colman, Eric 1 Sahlroot, Todd 1; Affiliation: 1: Division of Metabolic and Endocrine Drug Products, Office of Drug Evaluation 2, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA; Source Info: 4/9/2005, Vol. 365 Issue 9467, p1306; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Side effects; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Venable, Richard M.
AU - Delaglio, Frank
AU - Norris, Scott E.
AU - Freedberg, Darón I.
T1 - The utility of residual dipolar couplings in detecting motion in carbohydrates: application to sucrose
JO - Carbohydrate Research
JF - Carbohydrate Research
Y1 - 2005/04/11/
VL - 340
IS - 5
M3 - Article
SP - 863
EP - 874
SN - 00086215
AB - Abstract: The solution structure and dynamics of sucrose are examined using a combination of NMR residual dipolar coupling and molecular mechanics force fields. It is found that the alignment tensors of the individual rings are different, and that fitting 35 measured residual dipolar couplings to structures with specific ϕ, ψ values indicates the presence of three major conformations: ϕ, ψ=(120°,270°), (45°,300°) and (90°,180°). Furthermore, fitting two structures simultaneously to the 35 residual dipolar couplings results in a substantial improvement in the fits. The existence of multiple conformations having similar stabilities is a strong indication of motion, due to the interconversion among these states. Results from four molecular mechanics force fields are in general agreement with the experimental results. However, there are major disagreements between force fields. Because fits of residual dipolar couplings to structures are dependent on the force field used to calculate the structures, multiple force fields were used to interpret NMR data. It is demonstrated that the pucker of the fructofuranosyl ring affects the calculated potential energy surface, and the fit to the residual dipolar couplings data. Previously published 13C nuclear relaxation results suggesting that sucrose is rigid are not inconsistent with the present results when motional timescales are considered. [Copyright &y& Elsevier]
AB - Copyright of Carbohydrate Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANIC compounds
KW - RELAXATION (Nuclear physics)
KW - POTENTIAL energy surfaces
KW - QUANTUM chemistry
KW - Carbohydrate dynamics
KW - Carbohydrate structure
KW - Heteronuclear NMR
KW - Residual dipolar coupling
KW - Sucrose
N1 - Accession Number: 18377407; Venable, Richard M. 1 Delaglio, Frank 2 Norris, Scott E. 1 Freedberg, Darón I. 1; Email Address: freedberg@cber.fda.gov; Affiliation: 1: Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM-419, MD 20852, USA 2: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disorders, 5 Center Drive, NIH, Bethesda, MD 20892, USA; Source Info: Apr2005, Vol. 340 Issue 5, p863; Subject Term: ORGANIC compounds; Subject Term: RELAXATION (Nuclear physics); Subject Term: POTENTIAL energy surfaces; Subject Term: QUANTUM chemistry; Author-Supplied Keyword: Carbohydrate dynamics; Author-Supplied Keyword: Carbohydrate structure; Author-Supplied Keyword: Heteronuclear NMR; Author-Supplied Keyword: Residual dipolar coupling; Author-Supplied Keyword: Sucrose; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.carres.2005.01.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Deszo, Eric L.
AU - Steenbergen, Susan M.
AU - Freedberg, Darón I.
AU - Vimr, Eric R.
T1 - Escherichia coil K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2005/04/12/
VL - 102
IS - 15
M3 - Article
SP - 5564
EP - 5569
SN - 00278424
AB - Potential O-acetylation of the sialic acid residues of Escherkhia coil K1, groups W-135, V. and C meningococci, and group B Strepto-coccus capsular polysaccharides modifies their immunogenicity and susceptibility to glycosidases. Despite the biological importance of O-acetylation, no sialic or polysialic acid O-acetyltrans-ferase has been identified in any system. Here we show that the E. coil K1 O-acetyltransferase encoded by neuO is genetically linked to the endo-neuraminidase tail protein gene of a chromosomal accretion element, designated CUS-3, with homology to lambdoid bacteriophage. Molecular epidemiological analysis established concordance between O-acetyltransferase and CUS-3 in a set of E. coli K1 strains. Deleting neuO eliminated enzymatic activity, which was restored by complementation in trans, and confirmed by 13C-NMR analysis of the acetylated product. Analysis of mutants that accumulate intracellular polysialic acid because of export defects (kpsM and kpsS) or an inability to synthesize the sialic acid precursor, N-acetylmannosamine (neuo), indicated that NeuO does not require constant association with its substrate for activity. DNA sequencing and PCR analysis of neuO from strains that had undergone random capsule form variation showed that slip strand DNA mispairing or unequal recombination resulted in gain or loss of (5'-AAGACTC-3')n heptanucleotide repeats (where ≈ 14-39) located in the neuO 5' region. These repeats code for a previously undescribed structure designated the poly(ψ) motif. The unexpected discovery of the neuO contingency locus (hypervariable gene controlling expression of a surface epitope) in E. coil, and of a potential phage for redistributing variant neuO alleles, provides a robust system for investigating the functions of localized hyper mutability in pathogen evolution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - IMMUNOGENETICS
KW - ACETYLTRANSFERASES
KW - DNA
KW - SIALIC acids
KW - ENTEROBACTERIACEAE
N1 - Accession Number: 16991412; Deszo, Eric L. 1 Steenbergen, Susan M. 1 Freedberg, Darón I. 2 Vimr, Eric R. 1; Email Address: ervimr@uiuc.edu; Affiliation: 1: Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802. 2: Laboratory of Biophysics, Center for Biologics Evaluation and Research/Food and Drug Administration, Bethesda, MD 20892.; Source Info: 4/12/2005, Vol. 102 Issue 15, p5564; Subject Term: ESCHERICHIA coli; Subject Term: IMMUNOGENETICS; Subject Term: ACETYLTRANSFERASES; Subject Term: DNA; Subject Term: SIALIC acids; Subject Term: ENTEROBACTERIACEAE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106485759
T1 - Screening for asymptomatic bacteriuria: recommendation statement.
AU - Calonge N
Y1 - 2005/04/15/
N1 - Accession Number: 106485759. Corporate Author: US Preventive Services Task Force. Language: English. Entry Date: 20050715. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Bacteriuria -- Diagnosis
KW - Bacteriuria -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Medical Practice, Evidence-Based
KW - Preventive Health Care
SP - 1575
EP - 1612
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 71
IS - 8
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Chair, US Preventive Services Task Force, c/o Program Director, USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; uspstf@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - López-Rivera, A.
AU - Suárez-Isla, B. A.
AU - Eilers, P. P.
AU - Beaudry, C. G.
AU - Hall, S.
AU - Fernández Amandi, M.
AU - Furey, A.
AU - James, K. J.
T1 - Improved high-performance liquid chromatographic method for the determination of domoic acid and analogues in shellfish: effect of pH.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2005/04/15/
VL - 381
IS - 8
M3 - Article
SP - 1540
EP - 1545
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Domoic acid (DA) is a naturally-occurring amino acid that causes a form of human intoxication called amnesic shellfish poisoning (ASP) following the consumption of shellfish. A rapid and sensitive HPLC-UV method has been developed for analysis of DA and analogues in shellfish without the need for SPE clean-up. Isocratic chromatographic separation of DA and its isomers from shellfish matrix interferences and from the prevalent amino acid, tryptophan, was achieved by careful control of the mobile phase pH. The optimised pH was found to be 2.5 when using a Luna(2) C18 column. Sample extraction was verified with control extracts from shellfish spiked at 5.0 and 10.0 µg/g of DA and with certified reference material. The average extraction efficiency was 98.5%. The calibration, based on mussel tissue spiked with DA standard, was linear in the range 0.05-5.0 µg/ml (r=0.9999) and the detection limit (signal:noise 3:1) was better than 25 ng/ml. The DA assay achieved good precision; %RSD=1.63 (intra-day,n=6) and %RSD=3.7 (inter-day,n=8). This method was successfully applied to a variety of shellfish species, allowing the rapid screening of a large number of samples per day (20-30), without the need for SPE clean-up. Quantitative data were obtained for shellfish samples containing domoic acid in the concentration range 0.25-330 µg/g. Using the same chromatographic conditions, LC-MS3 was used to determine DA and its isomers, isodomoic acid D andepi-domoic acid, in scallop tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SHELLFISH
KW - AQUATIC invertebrates
KW - AMINO acids
KW - HIGH performance liquid chromatography
KW - MASS spectrometry
KW - Amnesic shellfish poisoning
KW - Domoic acid
KW - Ion-trap mass spectrometry
N1 - Accession Number: 16865356; López-Rivera, A. 1; Email Address: amlopez@med.uchile.cl Suárez-Isla, B. A. 1 Eilers, P. P. 2 Beaudry, C. G. 2 Hall, S. 2 Fernández Amandi, M. 3 Furey, A. 3 James, K. J. 3; Affiliation: 1: Laboratory of Marine Toxins, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Santiago, Chile 2: U.S. Food and Drug Administration, CFSAN, Washington, DC, USA 3: PROTEOBIO, Mass Spectrometry Centre for Proteomics and Biotoxin Research, Department of Chemistry, Cork Institute of Technology, Cork, Ireland; Source Info: Apr2005, Vol. 381 Issue 8, p1540; Subject Term: SHELLFISH; Subject Term: AQUATIC invertebrates; Subject Term: AMINO acids; Subject Term: HIGH performance liquid chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Amnesic shellfish poisoning; Author-Supplied Keyword: Domoic acid; Author-Supplied Keyword: Ion-trap mass spectrometry; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 6p; Illustrations: 4 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1007/s00216-005-3109-4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ottinger, Mary Ann
AU - Wu, Julie M.
AU - Hazelton, Julie L.
AU - Abdelnabi, Mahmoud A.
AU - Thompson, Nichola
AU - Quinn, Michael L.
AU - Donoghue, Dan
AU - Schenck, Frank
AU - Ruscio, Michael
AU - Beavers, Joanne
AU - Jaber, Mark
T1 - Assessing the consequences of the pesticide methoxychlor: neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical
JO - Brain Research Bulletin
JF - Brain Research Bulletin
Y1 - 2005/04/15/
VL - 65
IS - 3
M3 - Article
SP - 199
EP - 209
SN - 03619230
AB - Abstract: Japanese quail provide an advantageous avian model for assessing long-term biological consequences of endocrine disrupting chemicals (EDCs). These studies examined route of exposure and vulnerability to biological impact of EDCs over the life cycle in a precocial avian model, the Japanese quail. Embryonic exposure occurs with maternal deposition and methoxychlor (MXC) accumulated with maternal exposure. Egg injections of MXC or estradiol at selected stages of development impacted hypothalamic neuroendocrine systems in hatchlings and affected sexual maturation, with evidence for long-term effects on neurotransmitters and male behavior. Two-generation dietary studies were conducted to examine transgenerational effects of EDCs. Adult quail (P1) were exposed to dietary MXC (0, 0.5 and 5ppm), with continued exposure in their offspring (F1), and control diet for all F2 chicks. Toxicological end points, including fertility, hatching success, and 14-day viability were unaffected. F1 and F2 male offspring from MXC-treated pairs MXC had impaired mating behavior and altered plasma hormones. These studies confirm neuroendocrine and behavioral measures as reliable indices of exposure to an estrogenic EDC. Moreover, maternal deposition remains a primary route of EDC exposure, with potential deleterious consequences for field birds, especially precocial species that appear to be particularly sensitive to embryonic EDC exposure. [Copyright &y& Elsevier]
AB - Copyright of Brain Research Bulletin is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - AGRICULTURAL chemicals
KW - ESTROGEN
KW - ORGANOCHLORINE compounds
KW - Estrogens
KW - Japanese quail
KW - Neuroendocrine systems
KW - Sexual behavior
N1 - Accession Number: 17638033; Ottinger, Mary Ann 1; Email Address: maotting@umd.edu Wu, Julie M. 1 Hazelton, Julie L. 1 Abdelnabi, Mahmoud A. 1 Thompson, Nichola 1 Quinn, Michael L. 1 Donoghue, Dan 2 Schenck, Frank 3 Ruscio, Michael 1 Beavers, Joanne 4 Jaber, Mark 4; Affiliation: 1: Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA 2: Department of Poultry Science, University of Arkansas, Fayetteville, AR, USA 3: US Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA, USA 4: Wildlife International Ltd., Easton, MD, USA; Source Info: Apr2005, Vol. 65 Issue 3, p199; Subject Term: PESTICIDES; Subject Term: AGRICULTURAL chemicals; Subject Term: ESTROGEN; Subject Term: ORGANOCHLORINE compounds; Author-Supplied Keyword: Estrogens; Author-Supplied Keyword: Japanese quail; Author-Supplied Keyword: Neuroendocrine systems; Author-Supplied Keyword: Sexual behavior; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.brainresbull.2004.11.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106529422
T1 - News you can use: implications for your practice. The glycemic index: how is it useful?
AU - Whyte JJ
Y1 - 2005/04/15/
N1 - Accession Number: 106529422. Language: English. Entry Date: 20051021. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110.
KW - Glycemic Index
KW - Clinical Assessment Tools
SP - 558
EP - 560
JO - Consultant (00107069)
JF - Consultant (00107069)
JA - CONSULTANT
VL - 45
IS - 5
CY - Framingham, Massachusetts
PB - United Business Media
SN - 0010-7069
AD - Medical Advisor, US Department of Health and Human Services, Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cieślak, Jacek
AU - Ausín, Cristina
AU - Chmielewski, Marcin K.
AU - Kauffman, Jon S.
AU - Snyder, John
AU - Del-Grosso, Alfred
AU - Beaucage, Serge L.
T1 - 31P NMR Study of the Desulfurization of Oligonucleoside Pho sphorothioates Effected by "Aged" Trichloroacetic Acid Solutions.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2005/04/15/
VL - 70
IS - 8
M3 - Article
SP - 3303
EP - 3306
SN - 00223263
AB - When employing phosphoramidites la-d in the solid-phase synthesis of oligonucleoside phosphorothioates, the thermolytic 2-[N-methyl-N-(2-pyridyl)] aminoethyl thiophosphate protecting group is lost to a large extent during the course of the synthesis. The resulting phosphorothioate diesters are then substantially desulfurized upon recurring exposure to a commercial solution of deblocking reagent during chain assembly. This problem is caused by the secondary decomposition product(s) of the reagent and is alleviated by using a fresh solution of the deblocking reagent prepared from solid trichloroacetic acid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOSIDES
KW - PHOSPHORUS compounds
KW - DESULFURIZATION
KW - NUCLEAR magnetic resonance
KW - THIOPHOSPHATES
KW - ELIMINATION reactions
N1 - Accession Number: 16843630; Cieślak, Jacek 1 Ausín, Cristina Chmielewski, Marcin K. 1 Kauffman, Jon S. 2 Snyder, John 2 Del-Grosso, Alfred 3 Beaucage, Serge L.; Email Address: beaucage@cber.fda.gov; Affiliation: 1: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland 2: Lancaster Laboratories, 2425 New Holland Pike, Lancaster, Pennsylvania 17605-2425 3: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892; Source Info: 4/15/2005, Vol. 70 Issue 8, p3303; Subject Term: NUCLEOSIDES; Subject Term: PHOSPHORUS compounds; Subject Term: DESULFURIZATION; Subject Term: NUCLEAR magnetic resonance; Subject Term: THIOPHOSPHATES; Subject Term: ELIMINATION reactions; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 4p; Illustrations: 1 Diagram, 3 Graphs; Document Type: Article
L3 - 10.1021/jo050035n
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desmezieres, Emmanuel
AU - Gupta, Nidhi
AU - Vassell, Russell
AU - Yong He
AU - Peden, Keith
AU - Sirota, Lev
AU - Zhongning Yang
AU - Wingfield, Paul
AU - Weiss, Carol D.
T1 - Human Immunodeficiency Virus (HIV) gp41 Escape Mutants: Cross-Resistance to Peptide Inhibitors of HIV Fusion and Altered Receptor Activation of gp120.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/04/15/
VL - 79
IS - 8
M3 - Article
SP - 4774
EP - 4781
SN - 0022538X
AB - Human immunodeficiency virus (HIV) infects cells by fusing with cellular membranes. Fusion occurs when the envelope glycoprotein (Env) undergoes conformational changes while binding to cellular receptors. Fusogenic changes involve assembly of two heptad repeats in the ectodomain of the gp41 transmembrane subunit to form a six-helix bundle (6HB), consisting of a trimeric N heptad repeat (N-HR) coiled-coil core with three antiparallel C heptad repeats (C-HRs) that pack in the coiled-coil grooves. Peptides corresponding to the N-and C-HRs (N and C peptides, respectively) interfere with formation of the 6HB in a dominant-negative manner and are emerging as a new class of antiretroviral therapeutics for treating HIV infection. We generated an escape mutant virus with resistance to an N peptide and show that early resistance involved two mutations, one each in the N- and C-HRs. The mutations conferred resistance not only to the selecting N peptide but also to C peptides, as well as other types of N-peptide inhibitors. Moreover, the N-HR mutation altered sensitivity to soluble CD4. Biophysical studies suggest that the 6HB with the resistance mutations is more stable than the wild-type 6HB and the 6HB formed by inhibitor binding to either wild-type or mutant C-HR. These findings provide new insights into potential mechanisms of resistance to HIV peptide fusion inhibitors and dominant-negative inhibitors in general. The results are discussed in the context of current models of Env-mediated membrane fusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - CELL membranes
KW - MEMBRANE fusion
KW - INFECTION
KW - GLYCOPROTEINS
KW - CELL receptors
N1 - Accession Number: 16785965; Desmezieres, Emmanuel 1 Gupta, Nidhi 1 Vassell, Russell 1 Yong He 1 Peden, Keith 1 Sirota, Lev 2 Zhongning Yang Wingfield, Paul 3 Weiss, Carol D. 1; Email Address: cdweiss@helix.nih.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, U. S. 2: Division of Biostatistics, Center for Biologics Evaluation and Research, U. S. 3: Food and Drug Administration, and Protein Expression Lab, National Institute of Arthritis and Musculoskeletal Diseases, National Institutes of Health, Bethesda; Source Info: Apr2005, Vol. 79 Issue 8, p4774; Subject Term: HIV (Viruses); Subject Term: CELL membranes; Subject Term: MEMBRANE fusion; Subject Term: INFECTION; Subject Term: GLYCOPROTEINS; Subject Term: CELL receptors; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.8.4774-4781.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kinney, Richard M.
AU - Huang, Claire Y.-H.
AU - Rose, Becky C.
AU - Kroeker, Andrew D.
AU - Dreher, Theo W.
AU - Iversen, Patrick L.
AU - Stein, David A.
T1 - Inhibition of Dengue Virus Serotypes 1 to 4 in Vero Cell Cultures with Morpholino Oligomers.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/04/15/
VL - 79
IS - 8
M3 - Article
SP - 5116
EP - 5128
SN - 0022538X
AB - Five dengue (DEN) virus-specific R5F2R4 peptide-conjugated phosphorodiamidate morpholino oligomers (P4-PMOs) were evaluated for their ability to inhibit replication of DEN virus serotype 2 (DEN-2 virus) in mammalian cell culture. Initial growth curves of DEN-2 virus 16681 were obtained in Vero cells incubated with 20 µM P4-PMO compounds. At 6 days after infection, a P4-PMO targeting the 3′-terminal nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed relatively little suppression of DEN-2 virus titer (0.1 and 0.9 log10, respectively). P4-PMOs targeting the AUG translation start site region of the single open reading frame and the 5′ cyclization sequence region had moderate activity, generating 1.6- and 1.8-log10 reductions. Two P4-PMO compounds, 5′SL and 3′CS (targeting the 5′-terminal nucleotides and the 3′ cyclization sequence region, respectively), were highly efficacious, each reducing the viral titer by greater than 5.7 log10 compared to controls at 6 days after infection with DEN-2 virus. Further experiments showed that 5′SL and 3′CS inhibited DEN-2 virus replication in a dose-dependent and sequence-specific manner. Treatment with 10 µM 3′CS reduced the titers of all four DEN virus serotypes, i.e., DEN-1 (strain 16007), DEN-2 (16681), DEN-3 (16562), and DEN-4 (1036) viruses by over 4 log10, in most cases to below detectable limits. The extent of 3′CS efficacy was affected by the timing of compound application in relation to viral infection of the cells. The 5′SL and 3′CS P4-PMOs did not suppress the replication of West Nile virus NY99 in Vero cells. These data indicate that further evaluation of the 5′SL and 3′CS compounds as potential DEN virus therapeutics is warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - OLIGOMERS
KW - VIRAL replication
KW - CHEMICAL inhibitors
KW - CELL culture
KW - THERAPEUTICS
N1 - Accession Number: 16785998; Kinney, Richard M. 1 Huang, Claire Y.-H. 1 Rose, Becky C. 1 Kroeker, Andrew D. 2 Dreher, Theo W. 3 Iversen, Patrick L. 2 Stein, David A. 2; Email Address: steind@avibio.com; Affiliation: 1: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US. Department of Health and Human Services, Fort Collins, Colorado 2: AVI BioPhar,na, Inc., Corvallis, Oregon 3: Department of Microbiology, Oregon State University, Corvallis, Oregon; Source Info: Apr2005, Vol. 79 Issue 8, p5116; Subject Term: DENGUE viruses; Subject Term: OLIGOMERS; Subject Term: VIRAL replication; Subject Term: CHEMICAL inhibitors; Subject Term: CELL culture; Subject Term: THERAPEUTICS; Number of Pages: 13p; Illustrations: 8 Color Photographs, 1 Diagram, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.8.5116-5128.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vugia, D.
AU - Cronquist, A.
AU - Hadler, J.
AU - Tobin-D'Angelo, M.
AU - Blythe, D.
AU - Smith, K.
AU - Thornton, K.
AU - Morse, D.
AU - Cieslak, P.
AU - Jones, T.
AU - Varghese, R.
AU - Guzewich, J.
AU - Angulo, F.
AU - Griffin, P.
AU - Tauxe, R.
AU - Dunn, J.
T1 - Preliminary FoodNet Data on the Incidence of Infection with Pathogens Transmitted Commonly Through Food -- 10 Sites, United States, 2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04/15/
VL - 54
IS - 14
M3 - Article
SP - 352
EP - 356
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Describes the 2004 preliminary surveillance data collected by the Foodborne Diseases Active Surveillance Network from the U.S. regarding diseases caused by enteric pathogens transmitted through food. Infections identified by the surveillance; Comparison of the 2004 data with the data during 1996-1998; Factors which contributed to the decline of the incidence of infections.
KW - PUBLIC health surveillance
KW - FOODBORNE diseases
KW - PATHOGENIC microorganisms
KW - INFECTION
KW - UNITED States
N1 - Accession Number: 16780042; Vugia, D. 1 Cronquist, A. 2 Hadler, J. 3 Tobin-D'Angelo, M. 4 Blythe, D. 5 Smith, K. 6 Thornton, K. 7 Morse, D. 8 Cieslak, P. 9 Jones, T. 10 Varghese, R. 11 Guzewich, J. 12 Angulo, F. 13 Griffin, P. 13 Tauxe, R. 13 Dunn, J. 14; Affiliation: 1: California Dept. of Health Svcs. 2: Colorado Dept of Public Health and Environment 3: Connecticut Dept of Public Health 4: Div of Public Health, Georgia Dept of Human Resources 5: Maryland Dept of Health and Mental Hygiene 6: Minnesota Dept of Health 7: Institute for Public Health, Univ of New Mexico Health Sciences Center, Albuquerque 8: New York State Dept of Health 9: Oregon Dept of Human Svcs. 10: Tennessee Dept of Health 11: Office of Public Health Science, Food Safety and Inspection Svc, US Dept of Agriculture 12: Center for Food Safety and Applied Nutrition, Food and Drug Admin. 13: Div of Bacterial and Myotic Diseases, National Center for Infectious Diseases 14: EIS Officer, CDC; Source Info: 4/15/2005, Vol. 54 Issue 14, p352; Subject Term: PUBLIC health surveillance; Subject Term: FOODBORNE diseases; Subject Term: PATHOGENIC microorganisms; Subject Term: INFECTION; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Gregory J.
AU - Wilson, Monita P.
AU - Majerus, Philip W.
AU - Hurley, James H.
T1 - Specificity Determinants in Inositol Polyphosphate Synthesis: Crystal Structure of Inositol 1,3,4-Trisphosphate 5/6-Kinase
JO - Molecular Cell
JF - Molecular Cell
Y1 - 2005/04/15/
VL - 18
IS - 2
M3 - Article
SP - 201
EP - 212
SN - 10972765
AB - Summary: Inositol hexakisphosphate and other inositol high polyphosphates have diverse and critical roles in eukaryotic regulatory pathways. Inositol 1,3,4-trisphosphate 5/6-kinase catalyzes the rate-limiting step in inositol high polyphosphate synthesis in animals. This multifunctional enzyme also has inositol 3,4,5,6-tetrakisphosphate 1-kinase and other activities. The structure of an archetypal family member, from Entamoeba histolytica, has been determined to 1.2 Å resolution in binary and ternary complexes with nucleotide, substrate, and product. The structure reveals an ATP-grasp fold. The inositol ring faces ATP edge-on such that the 5- and 6-hydroxyl groups are nearly equidistant from the ATP γ-phosphate in catalytically productive phosphoacceptor positions and explains the unusual dual site specificity of this kinase. Inositol tris- and tetrakisphosphates interact via three phosphate binding subsites and one solvent-exposed site that could in principle be occupied by 18 different substrates, explaining the mechanisms for the multiple specificities and catalytic activities of this enzyme. [Copyright &y& Elsevier]
AB - Copyright of Molecular Cell is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INOSITOL
KW - POLYPHOSPHATES
KW - VITAMIN B complex
KW - ENTAMOEBA histolytica
N1 - Accession Number: 19178499; Miller, Gregory J. 1 Wilson, Monita P. 2 Majerus, Philip W. 2 Hurley, James H. 1; Email Address: jh8e@nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 2: Division of Hematology, Washington University School of Medicine, St. Louis, Missouri 63110; Source Info: Apr2005, Vol. 18 Issue 2, p201; Subject Term: INOSITOL; Subject Term: POLYPHOSPHATES; Subject Term: VITAMIN B complex; Subject Term: ENTAMOEBA histolytica; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.molcel.2005.03.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bala, Shukal
AU - Weaver, James
AU - Hastings, Kenneth L.
T1 - Clinical relevance of preclinical testing for allergic side effects
JO - Toxicology
JF - Toxicology
Y1 - 2005/04/15/
VL - 209
IS - 2
M3 - Article
SP - 195
EP - 200
SN - 0300483X
AB - Abstract: Immune-mediated hypersensitivity reactions include exaggerated humoral or cell mediated responses to specific antigens and may culminate in adverse, potentially life threatening effects. The immune status of the host and presence of infections or other disorders can alter the kind and extent of immune mediated side effects in individuals. Such variability in the immune status may influence the type of idiosyncratic reaction(s) that patients manifest. The issues typically encountered from a drug development standpoint include the potential for contact hypersensitivity, respiratory sensitivity, systemic hypersensitivity, photoallergy, and pseudoallergy. There are no accepted in vitro or in vivo models available to measure and predict all types of hypersensitivity reactions in humans. There is a need for the development of preclinical models to predict all types of hypersensitivity reactions in humans. The FDA immunotoxicology guidance document recommends doing preclinical testing in animal models for topical and inhalational drugs before initiation of multiple dose studies in humans. Any signs of potential immune related drug hypersensitivity should be further evaluated in an attempt to further understand the potential for hypersensitivity reactions in humans. In summary, existing preclinical models have limited capability for prediction of drug allergy in humans except for topical and inhalational drugs. Additional tools are needed to evaluate drugs in early development and improve performance of existing assays. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGY
KW - IMMUNOLOGIC diseases
KW - DRUGS -- Side effects
KW - CLINICAL trials
KW - Allergy
KW - Animal models
KW - Biomarkers
KW - Contact
KW - Drug
KW - Hypersensitivity
KW - Immune
KW - Preclinical testing
KW - Respiratory
KW - Systemic
N1 - Accession Number: 17515943; Bala, Shukal 1; Email Address: balas@cder.fda.gov Weaver, James 2 Hastings, Kenneth L. 3; Affiliation: 1: Division of Special Pathogen and Immunologic Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA 2: Office of Testing and Research, Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20857, USA 3: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: Apr2005, Vol. 209 Issue 2, p195; Subject Term: ALLERGY; Subject Term: IMMUNOLOGIC diseases; Subject Term: DRUGS -- Side effects; Subject Term: CLINICAL trials; Author-Supplied Keyword: Allergy; Author-Supplied Keyword: Animal models; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Contact; Author-Supplied Keyword: Drug; Author-Supplied Keyword: Hypersensitivity; Author-Supplied Keyword: Immune; Author-Supplied Keyword: Preclinical testing; Author-Supplied Keyword: Respiratory; Author-Supplied Keyword: Systemic; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.tox.2004.12.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barnes, Peter
AU - Price, Lorna
AU - Maddocks, Alison
AU - Cheung, W.Y.
AU - Williams, John
AU - Jackson, Sonia
AU - Mason, Brendan
T1 - Immunisation status in the public care system: A comparative study
JO - Vaccine
JF - Vaccine
Y1 - 2005/04/15/
VL - 23
IS - 21
M3 - Article
SP - 2820
EP - 2823
SN - 0264410X
AB - Abstract: Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6months was compared to that noted in 119 age and sex matched children living in their own homes. Children in public care were significantly less likely to have received immunisations against diphtheria, tetanus, pertussis and polio, than the comparison group. This represents a persisting health disadvantage, which requires remedial action. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunity
KW - Child care
KW - Clostridium diseases
KW - Anaerobic infections
KW - Children in public care
KW - Immunisation status
KW - Looked after children
N1 - Accession Number: 16769272; Barnes, Peter 1; Email Address: peter.barnes@swansea-tr.nhs.wales.uk; Price, Lorna 1; Maddocks, Alison 1; Cheung, W.Y. 2; Williams, John 2; Jackson, Sonia 3; Mason, Brendan 4; Affiliations: 1: Department of Community Child Health, Swansea NHS Trust, Central Clinic, 21, Orchard Street, Swansea SA1 5AT, UK; 2: The Clinical School, University of Wales, Swansea, Singleton Park, Swansea SA2 8PP, UK; 3: School of Social Sciences and International Development, University of Wales, Singleton Park, Swansea SA2 8PP, UK; 4: National Public Health Service, Abton House, Wedal Road, Cardiff CF14 3QX, UK; Issue Info: Apr2005, Vol. 23 Issue 21, p2820; Thesaurus Term: Immunity; Subject Term: Child care; Subject Term: Clostridium diseases; Subject Term: Anaerobic infections; Author-Supplied Keyword: Children in public care; Author-Supplied Keyword: Immunisation status; Author-Supplied Keyword: Looked after children; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.12.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Edlin, Brian R.
AU - Kresina, Thomas F.
AU - Raymond, Daniel B.
AU - Carden, Michael R.
AU - Gourevitch, Marc N.
AU - Rich, Josiah D.
AU - Cheever, Laura W.
AU - Cargill, Victoria A.
T1 - Overcoming Barriers to Prevention, Care, and Treatment of Hepatitis C in Illicit Drug Users.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/04/16/4/15/2005 Supplement
VL - 40
M3 - Article
SP - S276
EP - S285
SN - 10584838
AB - Injection drug use accounts for most of the incident infections with hepatitis C virus (HCV) in the United States and other developed countries. HCV infection is a complex and challenging medical condition in injection drug users (IDUs). Elements of care for hepatitis C in illicit drug users include prevention counseling and education; screening for transmission risk behavior; testing for HCV and human immunodeficiency virus infection; vaccination against hepatitis A and B viruses; evaluation for comorbidities; coordination of substance- abuse treatment services, psychiatric care, and social support; evaluation of liver disease; and interferon-based treatment for HCV infection. Caring for patients who use illicit drugs presents challenges to the health-care team that require patience, experience, and an understanding of the dynamics of substance use and addiction. Nonetheless, programs are successfully integrating hepatitis C care for IDUs into health-care settings, including primary care, methadone treatment and other substance-abuse treatment programs, infectious disease clinics, and clinics in correctional facilities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Antiviral agents
KW - Communicable diseases
KW - Hepatitis C
KW - Liver diseases
KW - Therapeutics
KW - Viral hepatitis
KW - Health facilities
N1 - Accession Number: 16582812; Edlin, Brian R. 1; Kresina, Thomas F. 2; Raymond, Daniel B. 3; Carden, Michael R. 1; Gourevitch, Marc N. 4; Rich, Josiah D. 5; Cheever, Laura W. 6; Cargill, Victoria A. 7; Email Address: vc5zx@nih.gov.; Affiliations: 1: Center for the Study of Hepatitis C, Weill Medical College of Cornell University; 2: Center on AIDS and Other Medical Consequences of Drug Abuse, National Institute on Drug Abuse; 3: Harm Reduction Coalition, New York, New York; 4: Division of General Internal Medicine, New York University School of Medicine; 5: Miriam Hospital, Brown University School of Medicine, Providence, Rhode Island; 6: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Washington, DC; 7: Office of AIDS Research, National Institutes of Health, Bethesda, Maryland; Issue Info: 4/15/2005 Supplement, Vol. 40, pS276; Thesaurus Term: Virus diseases; Thesaurus Term: Antiviral agents; Thesaurus Term: Communicable diseases; Subject Term: Hepatitis C; Subject Term: Liver diseases; Subject Term: Therapeutics; Subject Term: Viral hepatitis; Subject Term: Health facilities; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dong, R.G.
AU - Rakheja, S.
AU - McDowell, T.W.
AU - Welcome, D.E.
AU - Wu, J.Z.
AU - Warren, C.
AU - Barkley, J.
AU - Washington, B.
AU - Schopper, A.W.
T1 - A method for assessing the effectiveness of anti-vibration gloves using biodynamic responses of the hand–arm system
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2005/04/22/
VL - 282
IS - 3-5
M3 - Article
SP - 1101
EP - 1118
SN - 0022460X
AB - Abstract: Anti-vibration gloves are widely used to help minimize hand–arm vibration exposure. In this study, an alternative method is proposed to assess the vibration isolation effectiveness of these gloves using the biodynamic responses of the bare- and gloved-hand–arm system exposed to vibration. The laboratory experiments were performed with a total of five human subjects using a typical anti-vibration air bladder glove subjected to a broad-band random vibration spectrum in conjunction with a specially designed instrumented handle. The measured data were analyzed to derive the biodynamic responses of the bare as well as gloved human hand–arm system in terms of the apparent mass and the mechanical impedance. The two biodynamic responses were applied to estimate the vibration isolation effectiveness of the glove. The validity of the proposed concept was examined by comparing the estimated vibration transmissibility magnitudes of the glove with those obtained using a palm adapter method. The comparison of the results suggests that the proposed method offers a good alternative for estimating glove vibration transmissibility. The measured data and the proposed method based upon the biodynamic responses were further used to investigate the effect of the palm adapter on the vibration transmissibility of the glove. The results suggest that the presence of the palm adapter between the subject''s palm and the glove may not alter the basic trends in the transmissibility response, but it would affect the transmissibility magnitudes in the middle- and high-frequency ranges. A distinct advantage of the proposed method is that it eliminates the use of an adapter in assessing the vibration isolation effectiveness of the gloves. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRATION (Mechanics)
KW - LABORATORIES
KW - OSCILLATIONS
KW - VIBRATIONAL spectra
KW - dynamic response
N1 - Accession Number: 17524212; Dong, R.G. 1; Email Address: rkd6@cdc.gov Rakheja, S. 2 McDowell, T.W. 1 Welcome, D.E. 1 Wu, J.Z. 1 Warren, C. 1 Barkley, J. 1 Washington, B. 1 Schopper, A.W. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Engineering & Control Technology Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Concordia University CONCAVE Research Centre, Department of Mechanical Engineering, 1455, de Maisonneuve Blvd., W. Montreal, Quebec, Canada H3G 1M8; Source Info: Apr2005, Vol. 282 Issue 3-5, p1101; Subject Term: VIBRATION (Mechanics); Subject Term: LABORATORIES; Subject Term: OSCILLATIONS; Subject Term: VIBRATIONAL spectra; Author-Supplied Keyword: dynamic response; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.jsv.2004.03.069
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sim, Joon-Soo
AU - Jun, Gyungjin
AU - Toida, Toshihiko
AU - Cho, So Yean
AU - Choi, Don Woong
AU - Chang, Seung-Yeup
AU - Linhardt, Robert J.
AU - Kim, Yeong Shik
T1 - Quantitative analysis of chondroitin sulfate in raw materials, ophthalmic solutions, soft capsules and liquid preparations
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2005/04/25/
VL - 818
IS - 2
M3 - Article
SP - 133
EP - 139
SN - 15700232
AB - Abstract: We performed the quantitative analysis of chondroitin sulfate (CS) obtained from raw materials and various pharmaceutical preparations. To quantify CS content in raw materials and in an ophthalmic solution, each test sample and the authentic CS were first digested by chondroitinase ABC. The CS disaccharides produced were analyzed by strong anion-exchange high-performance liquid chromatography (SAX-HPLC) and CS content was quantified by calculating the total peak areas of the disaccharides derived from a CS calibration curve. In the case of soft capsules, CS was first extracted with hexane followed by phenol–chloroform to remove oil and protein ingredients. The extracted CS samples were depolymerized by chondroitinase ABC and CS content was determined. Quantitative analysis of the disaccharides derived from raw materials and an ophthalmic solution showed the CS contents (%) were 39.5±0.1 to 105.6±0.1 and 103.3±1.2, respectively. In case of CS analysis in soft capsules and liquid preparations, the overall recovery (%) of the spiked CS was 96.79±0.53–103.54±1.78 and 97.10±1.82 to 103.17±2.34, respectively. In conclusion, the quantitative analysis of the disaccharides produced by enzymatic digestion can be used in the direct quantitation of CS containing pharmaceutical formulations. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHONDROITIN
KW - CARBOHYDRATES
KW - LIQUID chromatography
KW - RAW materials
KW - CLINICAL drug trials
KW - Chondroitin sulfate
KW - Chondroitinase ABC
KW - Formulation material
KW - Liquid preparations
KW - Ophthalmic solutions
KW - Soft capsules
N1 - Accession Number: 19180200; Sim, Joon-Soo 1 Jun, Gyungjin 1 Toida, Toshihiko 2 Cho, So Yean 3 Choi, Don Woong 3 Chang, Seung-Yeup 3 Linhardt, Robert J. 4 Kim, Yeong Shik 1; Email Address: kims@plaza.snu.ac.kr; Affiliation: 1: Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yeonkun-Dong, Jongno-Ku, Seoul 110-460, South Korea 2: Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan 3: Korea Food and Drug Administration, Seoul 122-704, South Korea 4: Department of Chemistry and Chemical Biology, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA; Source Info: Apr2005, Vol. 818 Issue 2, p133; Subject Term: CHONDROITIN; Subject Term: CARBOHYDRATES; Subject Term: LIQUID chromatography; Subject Term: RAW materials; Subject Term: CLINICAL drug trials; Author-Supplied Keyword: Chondroitin sulfate; Author-Supplied Keyword: Chondroitinase ABC; Author-Supplied Keyword: Formulation material; Author-Supplied Keyword: Liquid preparations; Author-Supplied Keyword: Ophthalmic solutions; Author-Supplied Keyword: Soft capsules; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jchromb.2004.12.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19180200&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bang, K. M.
AU - Mazurek, J. M.
AU - Attfield, M. D.
T1 - Silicosis Mortality, Prevention, and Control -- United States, 1968--2002. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04/26/
VL - 54
IS - 16
M3 - Article
SP - 401
EP - 405
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the results of the analysis conducted by the U.S. Centers for Disease Control & Prevention to describe patterns of silicosis mortality in the U.S. Cause of silicosis; Information on the National Occupational Respiratory Mortality System for 1968-2002; Racial distribution of persons who died from silicosis.
KW - SILICOSIS
KW - LUNGS -- Dust diseases
KW - MORTALITY
KW - OCCUPATIONAL hazards
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 16940499; Bang, K. M. 1 Mazurek, J. M. 1 Attfield, M. D. 1; Affiliation: 1: Div. of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 4/26/2005, Vol. 54 Issue 16, p401; Subject Term: SILICOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: MORTALITY; Subject Term: OCCUPATIONAL hazards; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Settimi, L.
AU - Marcello, I.
AU - Davanzo, F.
AU - Faraoni, L.
AU - Miceli, G.
AU - Richmond, D.
AU - Calvert, G. M.
T1 - Update: Hydrogen Cyanamide-- Related Illnesses -- Italy, 2002--2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/04/26/
VL - 54
IS - 16
M3 - Article
SP - 405
EP - 408
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Describes cases of hydrogen cyanamide-related illness that occurred during 2002-2004 in the U.S. Adverse health effects from contact with hydrogen cyanamide; Acetaldehyde syndrome produce by hydrogen cyanamide; Information on a 2000 pilot pesticide-poisoning surveillance program undertaken by the Italian National Institute of Health in collaboration with the Milan Poison Control Center and the Ragusa Local Health Unit.
KW - PESTICIDES -- Toxicology
KW - ACETALDEHYDE
KW - PUBLIC health
KW - UNITED States
KW - ITALY
N1 - Accession Number: 16940521; Settimi, L. 1 Marcello, I. 1 Davanzo, F. 2 Faraoni, L. 2 Miceli, G. 3 Richmond, D. 4 Calvert, G. M. 5; Affiliation: 1: National Institute of Health, Rome 2: Milan Poison Control Center, Cà Granda Hospital, Milan 3: Occupational Health Svc, Ragusa Local Health Unit, Ragusa, Italy 4: California Dept of Pesticide Regulation 5: Div of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 4/26/2005, Vol. 54 Issue 16, p405; Subject Term: PESTICIDES -- Toxicology; Subject Term: ACETALDEHYDE; Subject Term: PUBLIC health; Subject Term: UNITED States; Subject Term: ITALY; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keshava, Channa
AU - Whipkey, Diana
AU - Weston, Ainsley
T1 - Transcriptional signatures of environmentally relevant exposures in normal human mammary epithelial cells: benzo[a]pyrene
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2005/04/28/
VL - 221
IS - 2
M3 - Article
SP - 201
EP - 211
SN - 03043835
AB - Abstract: Changes in gene expression in a panel of primary normal human mammary epithelial cell strains, developed from healthy breast tissue obtained at reduction mammoplasty from different donors, in response to benzo[a]pyrene exposure have been investigated. It was expected that both gene expression changes common to cell strains derived from different donors as well as inter-individual variation would be observed. Therefore, the strategy that has been adopted is to identify potentially important changes, or useful changes from a biomonitoring perspective, using gene-array technology and a small number of donors; then investigate selected transcription responses using a large number of tissue donors and a cheaper method of transcript detection (real-time polymerase chain reaction). Here we report results from four primary normal human mammary epithelial cell strains that were treated with benzo[a]pyrene in vitro for either 6 or 24h. Transcription was monitored using high-density oligonucleotide arrays (Affymetrix HuGeneFL). Total RNA was used for the preparation of labeled targets that were hybridized to microarrays containing probes representing more than 6800 human genes and expressed sequence tags. Gene expression data were analyzed using the GeneChip® software (MAS 5.0). Altered gene expression patterns were observed in response to benzo[a]pyrene in human mammary epithelial cell strains from different donors. Specifically, the dioxin inducible cytochrome P450 CYP1B1 was consistently induced in response to 6 and 24h exposure to benzo[a]pyrene in cell strains from all four donors. Two other genes that were relatively consistently induced were IL1β and MMP1. Less consistent changes in other metabolism genes (CYP1A1, CYP11B2, and NQO1) and certain cell cycle control genes GOS2 and AF1Q were also induced, while EGR1 was suppressed. Although no change in p53 transcription was observed, an accumulation of p53 protein was detected using antibodies. A similar accumulation of Waf1 (p21) was also observed using immunohistochemistry, this was expected since p53 is p21''s transcription factor. Significant inter-individual variations in both the levels and patterns of gene expression were observed, in response to benzo[a]pyrene exposure. These studies provide a complementary approach to molecular epidemiology for the investigation of differential susceptibility to chemical carcinogens, and specifically polycyclic aromatic hydrocarbons. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - EPITHELIAL cells
KW - DNA polymerases
KW - POLYMERASE chain reaction
KW - benzo[a]pyrene (BP)
KW - Carcinogenesis
KW - Cooperative Human Tissue Network (CHTN)
KW - Fold Change (FC)
KW - Mammary cells
KW - National Cancer Institute (NCI)
KW - normal human mammary epithelial cell (NHMEC)
KW - Oligonucleotide arrays
KW - polycyclic aromatic hydrocarbon (PAH)
KW - Polycyclic aromatic hydrocarbons
KW - signal log ratio (SLR)
N1 - Accession Number: 19189185; Keshava, Channa 1 Whipkey, Diana 1 Weston, Ainsley; Email Address: agw8@cdc.gov; Affiliation: 1: Molecular Epidemiology Team, Health Effects Laboratory Division, National Institute for Occupational Safety and Health-CDC, Centers for Disease Control and Prevention, DHHS, 1095 Willowdale Road, M/S L-3014, Morgantown, WV 26505-2888, USA; Source Info: Apr2005, Vol. 221 Issue 2, p201; Subject Term: GENE expression; Subject Term: EPITHELIAL cells; Subject Term: DNA polymerases; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: benzo[a]pyrene (BP); Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Cooperative Human Tissue Network (CHTN); Author-Supplied Keyword: Fold Change (FC); Author-Supplied Keyword: Mammary cells; Author-Supplied Keyword: National Cancer Institute (NCI); Author-Supplied Keyword: normal human mammary epithelial cell (NHMEC); Author-Supplied Keyword: Oligonucleotide arrays; Author-Supplied Keyword: polycyclic aromatic hydrocarbon (PAH); Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; Author-Supplied Keyword: signal log ratio (SLR); Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.canlet.2004.08.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19189185&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keshava, Channa
AU - Divi, Rao L.
AU - Whipkey, Diana L.
AU - Frye, Bonnie L.
AU - McCanlies, Erin
AU - Kuo, Maryanne
AU - Poirier, Miriam C.
AU - Weston, Ainsley
T1 - Induction of CYP1A1 and CYP1B1 and formation of carcinogen–DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2005/04/28/
VL - 221
IS - 2
M3 - Article
SP - 213
EP - 224
SN - 03043835
AB - Abstract: Inter-individual variation in formation of carcinogen–DNA adducts and induction of cytochrome P450 genes was measured in 23 cultured normal human mammary epithelial cell (NHMEC) strains established from reduction mammoplasty tissue. Semi-confluent cells were exposed to 4μM benzo[a]pyrene (BP) for 12h and BP–DNA adduct levels were measured by chemiluminescence immunoassay using antiserum elicited against DNA modified with r7, t8-dihydroxy-t-9, 10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). BP–DNA adduct levels for 22 of 23 different cell strains ranged from non-detectable (three samples) to about 15 adducts/108 nucleotides. Increases in levels of CYP1A1 and CYP1B1 were detected using both oligonucleotide arrays and reverse transcription/quantitative real-time polymerase chain reactions (RT-PCRs). For CYP1A1 and CYP1B1, the oligonucleotide array data and RT-PCR data were highly correlated (r=0.73 and 0.70, respectively), suggesting that oligonucleotide arrays are a suitable gene discovery tool, and demonstrating that the complementary and efficient RT-PCR may be used to confirm microarray data for a specific gene in a large number of samples. As measured by RT-PCR, inter-individual variation in CYP1A1 induction was 100-fold, while the variation in CYP1B1 induction was almost 40-fold. On a per-person basis, CYP1A1 and CYP1B1 induction were well-correlated (r=0.88, P<0.001), which is to be expected as they are under the control of a common transcriptional regulation mechanism in response to BP exposure. Inter-individual variation in carcinogen–DNA adduct formation could not be explained only by variation in levels of CYP1A1 or CYP1B1 induction, as neither was well-correlated with BPDE–DNA adduct level (r=0.40 and 0.50 for CYP1A1 and CYP1B1, respectively). Evaluation of glutathione-S-transferase M1 genotype (GSTM1 positive or null) revealed an apparent correlation between positive GSTM1 genotype and BPDE–DNA adduct levels (r=0.84 and 0.77 for CYP1A1 and CYP1B1, respectively); however, after removal of the single outlier this relationship was not significant. Overall the data suggest that BPDE–DNA adduct levels in normal human breast tissue may be modulated by multiple factors that include, but are not exclusive to, CYP1A1 and CYP1B1 inducibility and the presence or absence of GSTM1. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENESIS
KW - NUCLEIC acids
KW - GENETIC polymorphisms
KW - POLYMERASE chain reaction
KW - 2-[N-morpholino]-ethansulfonic acid (MES)
KW - 8-epoxide (BP-7-8-oxide)
KW - benzo[a]pyrene (BP)
KW - benzo[a]pyrene-7
KW - benzo[a]pyrene-7,8-epoxide (BP-7,8-oxide)
KW - BPdG
KW - Carcinogenesis
KW - Cell culture
KW - Chemiluminescence immunoassay
KW - chemiluminescence immunoassay (CIA)
KW - DNA damage
KW - GeneChip (GC)
KW - Metabolic activation
KW - National Institute for Occupational Safety and Health (NIOSH)
KW - normal human mammary epithelial cell (NHMEC)
KW - polycyclic aromatic hydrocarbon (PAH)
KW - Polycyclic aromatic hydrocarbons
KW - polymerase chain reaction (PCR)
KW - r7,t8,t9-trihydroxy-c-10-(N2deoxyguanosyl)-7,8,9,10-tetrahydrobenzo[a]pyrene
KW - r7,t8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene (BPDE)
KW - r7-t8-dihydroxy-t-9-10-epoxy-7-8-9D-10-tetrahydro-benzo[a]pyrene (BPDE)
KW - r7-t8-t9-trihydroxy-c-10-(N2deoxyguanosyl)-7-8-9-10-tetrahydrobenzo[a]pyrene
KW - reverse transcription (RT)
KW - trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene (BP-7,8-dihydrodiol)
KW - trans-7-8-dihydro-7-8-dihydroxybenzo[a]pyrene (BP-7-8-dihydrodiol)
N1 - Accession Number: 19189187; Keshava, Channa 1 Divi, Rao L. 2 Whipkey, Diana L. 1 Frye, Bonnie L. 1 McCanlies, Erin 3 Kuo, Maryanne 2 Poirier, Miriam C. 2 Weston, Ainsley 1; Email Address: agw8@cdc.gov; Affiliation: 1: Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA 2: Carcinogen–DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892-4255, USA 3: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, Morgantown, WV, USA; Source Info: Apr2005, Vol. 221 Issue 2, p213; Subject Term: CARCINOGENESIS; Subject Term: NUCLEIC acids; Subject Term: GENETIC polymorphisms; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: 2-[N-morpholino]-ethansulfonic acid (MES); Author-Supplied Keyword: 8-epoxide (BP-7-8-oxide); Author-Supplied Keyword: benzo[a]pyrene (BP); Author-Supplied Keyword: benzo[a]pyrene-7; Author-Supplied Keyword: benzo[a]pyrene-7,8-epoxide (BP-7,8-oxide); Author-Supplied Keyword: BPdG; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Cell culture; Author-Supplied Keyword: Chemiluminescence immunoassay; Author-Supplied Keyword: chemiluminescence immunoassay (CIA); Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: GeneChip (GC); Author-Supplied Keyword: Metabolic activation; Author-Supplied Keyword: National Institute for Occupational Safety and Health (NIOSH); Author-Supplied Keyword: normal human mammary epithelial cell (NHMEC); Author-Supplied Keyword: polycyclic aromatic hydrocarbon (PAH); Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; Author-Supplied Keyword: polymerase chain reaction (PCR); Author-Supplied Keyword: r7,t8,t9-trihydroxy-c-10-(N2deoxyguanosyl)-7,8,9,10-tetrahydrobenzo[a]pyrene; Author-Supplied Keyword: r7,t8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene (BPDE); Author-Supplied Keyword: r7-t8-dihydroxy-t-9-10-epoxy-7-8-9D-10-tetrahydro-benzo[a]pyrene (BPDE); Author-Supplied Keyword: r7-t8-t9-trihydroxy-c-10-(N2deoxyguanosyl)-7-8-9-10-tetrahydrobenzo[a]pyrene; Author-Supplied Keyword: reverse transcription (RT); Author-Supplied Keyword: trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene (BP-7,8-dihydrodiol); Author-Supplied Keyword: trans-7-8-dihydro-7-8-dihydroxybenzo[a]pyrene (BP-7-8-dihydrodiol); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.canlet.2004.08.038
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yong Qian
AU - Xiaosong Zhong
AU - Flynn, Daniel C.
AU - Zheng, Jenny Z.
AU - Meng Qiao
AU - Chuanyue Wu
AU - Shoukat Dedhar
AU - Xianglin Shi
AU - Bing-Hua Jiang
T1 - ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.
JO - Oncogene
JF - Oncogene
Y1 - 2005/04/28/
VL - 24
IS - 19
M3 - Article
SP - 3154
EP - 3165
PB - Nature Publishing Group
SN - 09509232
AB - One of the hallmarks of integrin signaling is an increase in cell migration and invasion, both of which are associated with actin filament rearrangements. Integrin-linked kinase (ILK) is a cytoplasmic effector of integrin receptors. ILK is known to be involved in multiple cellular functions. However, the signaling pathways involved in ILK-mediated cellular structure and motility remain to be elucidated. Here, we have demonstrated that overexpression of ILK was sufficient to induce actin filament rearrangements, to form cell motility structures, and to increase cell migration and invasion in a phosphatidylinositol 3-kinase (PI3K)-dependent manner. This corresponds with the activation of both Akt and p70 ribosomal protein S6 kinase (p70S6K1). Overexpression of dominant-negative mutants of Akt inhibited ILK-dependent activation of p70S6K1, indicating that Akt is upstream of p70S6K1 in response to ILK signaling. Overexpression of ILK was sufficient to induce Rac1 activation, which was abolish by a PI3K inhibitor, indicating that Rac1 activity is involved in ILK signaling in a PI3K dependent manner. Inhibition of Akt, Rac1, or p70S6K1 inhibited the effects of ILK on actin filaments and cell migration, suggesting a regulatory role of the PI3K/Akt/p70S6K1/Rac1 signaling pathway in response to ILK signaling. We have shown that overexpression of a dominant-negative ILK was sufficient to abolish fibronectin peptide (PHSRN)-induced rearrangements of actin filaments and cell migration and invasion. Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region.Oncogene (2005) 24, 3154-3165. doi:10.1038/sj.onc.1208525 Published online 21 February 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL migration
KW - CYTOLOGY
KW - PROTEINS
KW - ACTOMYOSIN
KW - FIBRONECTINS
KW - BLOOD proteins
KW - actin filaments
KW - Akt
KW - ILK
KW - P13K
KW - p70S6K1
KW - Rac1
N1 - Accession Number: 16892824; Yong Qian 1; Email Address: yaq2@cdc.gov Xiaosong Zhong 2 Flynn, Daniel C. 2 Zheng, Jenny Z. 2 Meng Qiao 2 Chuanyue Wu 3 Shoukat Dedhar 4 Xianglin Shi 1 Bing-Hua Jiang 2; Email Address: bhjiang@hsc.wvu.edu; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA. 2: The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA. 3: Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA. 4: Department of Biochemistry, University of British Columbia, BC, Cancer Agency and Vancouver Hospital, Jack Bell Research Center, Vancouver, BC, Canada V6H 3Z6.; Source Info: 4/28/2005, Vol. 24 Issue 19, p3154; Subject Term: CELL migration; Subject Term: CYTOLOGY; Subject Term: PROTEINS; Subject Term: ACTOMYOSIN; Subject Term: FIBRONECTINS; Subject Term: BLOOD proteins; Author-Supplied Keyword: actin filaments; Author-Supplied Keyword: Akt; Author-Supplied Keyword: ILK; Author-Supplied Keyword: P13K; Author-Supplied Keyword: p70S6K1; Author-Supplied Keyword: Rac1; Number of Pages: 12p; Document Type: Article
L3 - 10.1038/sj.onc.1208525
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, D.B.
AU - O’Callaghan, J.P.
T1 - Aging, stress and the hippocampus
JO - Ageing Research Reviews
JF - Ageing Research Reviews
Y1 - 2005/05//
VL - 4
IS - 2
M3 - Article
SP - 123
EP - 140
SN - 15681637
AB - Abstract: Functional loss often occurs in many body systems (e.g., endocrine, cognitive, motor) with the passage of years, but there is great individual variation in the degree of compromise shown. The current focus on brain aging will continue because demographic trends indicate that the average lifespan will show a continued increase. There is increasing emphasis on understanding how aging contributes to a decline in brain functions, cognition being a prime example. This is due in part to the fact that dementias and other losses in brain function that sometimes accompany aging cause an obvious decline in the quality of life and these deficits are of more concern as the number of elderly increase. Stress also is a ubiquitous aspect of life and there is now a greater interest in understanding the role of stress and the stress response in brain aging. The key role of the hippocampus and its related brain structures in cognition, as well as in the feedback control of the response to stress, have made this brain area a logical focus of investigation for those interested in the impact of stress on brain aging. Here, we describe how the hippocampus changes with age and we examine the idea that age-related changes in the secretion patterns of the hypothalamic-pituitary adrenal (HPA) axis can contribute to aging of this structure. We also examine the proposal that stress, perhaps due to compromised HPA axis function, can contribute to hippocampal aging through exposure to excessive levels of glucocorticoids. The aging hippocampus does not appear to suffer a generalized loss of cells or synapses, although atrophy of the structure may occur in humans. Thus, age-related cognitive impairments are likely related to other neurobiological alterations that could include changes in the signaling, information encoding, plasticity, electrophysiological or neurochemical properties of neurons or glia. Although excessive levels of glucocorticoids are able to interfere with cognition, as well as hippocampal neuronal integrity, and aging is sometimes accompanied by an increase in these steroids because of inadequate feedback control of the HPA axis, none of these are a foregone consequence of aging. The general preservation of cells and the plastic potential of the hippocampus provide a focus for the development of pharmacological, nutritive or lifestyle strategies to combat age-related declines in the hippocampus as well as other brain areas. [Copyright &y& Elsevier]
AB - Copyright of Ageing Research Reviews is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRAIN -- Aging
KW - DEMENTIA
KW - QUALITY of life
KW - OLDER people -- Health
KW - HIPPOCAMPUS (Brain)
KW - Age
KW - Hippocampus
KW - Plasticity
KW - Stress
N1 - Accession Number: 18231634; Miller, D.B.; Email Address: dum6@cdc.gov O’Callaghan, J.P. 1; Affiliation: 1: Chronic Stress and Neurotoxicology Laboratories, TMBB-HELD, Mailstop L-3014, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health-CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: May2005, Vol. 4 Issue 2, p123; Subject Term: BRAIN -- Aging; Subject Term: DEMENTIA; Subject Term: QUALITY of life; Subject Term: OLDER people -- Health; Subject Term: HIPPOCAMPUS (Brain); Author-Supplied Keyword: Age; Author-Supplied Keyword: Hippocampus; Author-Supplied Keyword: Plasticity; Author-Supplied Keyword: Stress; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.arr.2005.03.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18231634&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Macher, Abe
AU - Kibble, Deborah
T1 - Issues in Correctional HIV Care: Hallucinogenic Amphetamine Derivatives-- Methamphetamine and 3, 4-Methylenedioxymethamphetamine.
JO - American Jails
JF - American Jails
Y1 - 2005/05//May/Jun2005
VL - 19
IS - 2
M3 - Article
SP - 55
EP - 57
SN - 10560319
AB - The article reports on issues related to correctional HIV care. Researchers reported that prisons are at high-risk environment for drug initiation and use. It is clear that abuse of amphetamine derivatives is associated with high-risk sexual behavior and transmission of sexually transmitted diseases including HlV. The public health community is struggling to respond effectively to these interwoven epidemics. The article further includes a case study of a man who was tested seronegative for HIV-I antibodies.
KW - HIV infections
KW - MEDICAL care
KW - COMMUNICABLE diseases
KW - CORRECTIONAL institutions
KW - SEXUALLY transmitted diseases
KW - PRISONS
N1 - Accession Number: 17538421; Macher, Abe 1 Kibble, Deborah 2; Affiliation: 1: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, US. Department of Health and Human Services, Rockville, Maryland. 2: Chronic Care Nurse, Prince William-Manassas Regional Adult Dtention Center, Manassas, Virginia.; Source Info: May/Jun2005, Vol. 19 Issue 2, p55; Subject Term: HIV infections; Subject Term: MEDICAL care; Subject Term: COMMUNICABLE diseases; Subject Term: CORRECTIONAL institutions; Subject Term: SEXUALLY transmitted diseases; Subject Term: PRISONS; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106491576
T1 - Guidance on public reporting of healthcare-associated infections: recommendations of the healthcare infection control practices advisory committee.
AU - McKibben L
AU - Horan T
AU - Tokars JI
AU - Fowler G
AU - Cardo DM
AU - Pearson ML
AU - Brennan PJ
Y1 - 2005/05//2005 May
N1 - Accession Number: 106491576. Corporate Author: Healthcare Infection Control Practices Advisory Committee. Language: English. Entry Date: 20050729. Revision Date: 20150819. Publication Type: Journal Article; glossary; practice guidelines. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Cross Infection -- Prevention and Control
KW - Disease Surveillance -- Standards
KW - Infection Control -- Standards
KW - Mandatory Reporting -- Legislation and Jurisprudence -- United States
KW - Policy Making
KW - Clinical Indicators
KW - Consumer Advocacy
KW - Government Agencies
KW - Organizational Structure
KW - Outcomes (Health Care)
KW - Patient Identification
KW - Patient Rights
KW - Practice Guidelines
KW - Process Assessment (Health Care)
KW - Public Health
KW - Reports
KW - Risk Assessment
KW - United States
KW - Validity
SP - 217
EP - 226
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 33
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - Since 2002, 4 states have enacted legislation that requires health care organizations to publicly disclose health care-associated infection (HAI) rates. Similar legislative efforts are underway in several other states. Advocates of mandatory public reporting of HAIs believe that making such information publicly available will enable consumers to make more informed choices about their health care and improve overall health care quality by reducing HAIs. Further, they believe that patients have a right to know this information. However, others have expressed concern that the reliability of public reporting systems may be compromised by institutional variability in the definitions used for HAIs, or in the methods and resources used to identify HAIs. Presently, there is insufficient evidence on the merits and limitations of an HAI public reporting system. Therefore, the Healthcare Infection Control Practices Advisory Committee (HICPAC) has not recommended for or against mandatory public reporting of HAI rates. However, HICPAC has developed this guidance document based on established principles for public health and HAI reporting systems. This document is intended to assist policymakers, program planners, consumer advocacy organizations, and others tasked with designing and implementing public reporting systems for HAIs. The document provides a framework for legislators, but does not provide model legislation. HICPAC recommends that persons who design and implement such systems 1) use established public health surveillance methods when designing and implementing mandatory HAI reporting systems; 2) create multidisciplinary advisory panels, including persons with expertise in the prevention and control of HAIs, to monitor the planning and oversight of HAI public reporting systems; 3) choose appropriate process and outcome measures based on facility type and phase in measures to allow time for facilities to adapt and to permit ongoing evaluation of data validity; and 4) provide regular and confidential feedback of performance data to healthcare providers. Specifically, HICPAC recommends that states establishing public reporting systems for HAIs select one or more of the following process or outcome measures as appropriate for hospitals or long-term care facilities in their jurisdictions: 1) central-line insertion practices; 2) surgical antimicrobial prophylaxis; 3) influenza vaccination coverage among patients and healthcare personnel; 4) central line-associated bloodstream infections; and 5) surgical site infections following selected operations. HICPAC will update these recommendations as more research and experience become available.
SN - 0196-6553
AD - Office of the Director, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, United States Department of Health and Human Services, Atlanta, GA
U2 - PMID: 15877016.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106639783
T1 - First, do no harm. Reducing pediatric medication errors: children are especially at risk for medication errors.
AU - Hughes RG
AU - Edgerton EA
Y1 - 2005/05//
N1 - Accession Number: 106639783. Language: English. Entry Date: 20050603. Revision Date: 20150819. Publication Type: Journal Article; equations & formulas; review; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Drug Administration -- Nursing
KW - Medication Errors -- Prevention and Control -- In Infancy and Childhood
KW - Pediatric Nursing
KW - Adolescence
KW - Body Surface Area
KW - Body Weight
KW - Child
KW - Child, Preschool
KW - Documentation
KW - Dosage Calculation
KW - Drugs
KW - Incident Reports
KW - Infant
KW - Infant, Newborn
KW - Information Resources
KW - Patient Discharge Education
KW - Prescriptions, Drug
KW - World Wide Web
SP - 79
EP - 85
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 105
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Senior Health Scientist Administrator, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD; rhughes@ahrq.gov
U2 - PMID: 15867545.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106639783&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ducatman, Alan M.
AU - Vanderploeg, James M.
AU - Johnson, Mark
AU - Rubin, Judith
AU - Harber, Philip
AU - Sokas, Rosemary
AU - Harmon, Robert G.
AU - Rumm, Peter
AU - Nilson, Elizabeth
AU - Batalden, Paul
AU - Merchant, Glenn
AU - Krauss, Margot
AU - Goldberg, Robert L.
AU - Valdez, Michael
AU - Dismuke, S. Edwards
AU - Wagner, Gregory R.
AU - Leniek, Karyn
AU - Rosenthal, Jill
T1 - Challenges and opportunities
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2005/05//
VL - 28
IS - 4
M3 - Article
SP - 403
EP - 412
SN - 07493797
N1 - Accession Number: 16992917; Ducatman, Alan M. 1; Email Address: aducatman@hsc.wvu.edu Vanderploeg, James M. 2 Johnson, Mark 3 Rubin, Judith 4,5 Harber, Philip 4,6 Sokas, Rosemary 7 Harmon, Robert G. 8 Rumm, Peter 4,9 Nilson, Elizabeth 4,10 Batalden, Paul 11 Merchant, Glenn 2,4,12 Krauss, Margot 4,13 Goldberg, Robert L. 14 Valdez, Michael 4 Dismuke, S. Edwards 15 Wagner, Gregory R. 16 Leniek, Karyn 17 Rosenthal, Jill 7; Affiliation: 1: Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, West Virginia 2: American Board of Preventive Medicine, Chicago, Illinois 3: Jefferson County Department of Health and Environment, Golden, Colorado 4: Residency Review Committee in Preventive Medicine 5: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 6: Division of Occupational and Environmental Medicine, Department of Family Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 7: Department of Environmental and Occupational Health Sciences, University of Illinois School of Public Health, Chicago, Illinois 8: Ingenix United Health Care Group, Eden Prairie, Minnesota 9: Center for Public Health Readiness and Communication, Drexel University School of Public Health, Philadelphia, Pennsylvania 10: Preventive Medicine Residency, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York 11: Health Care Improvement Leadership Development, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire 12: Department of Defense Center for Education and Research in Patient Safety, Bethesda, Maryland 13: Walter Reed Army Institute of Research, Silver Spring, Maryland 14: Division of Occupational and Environmental Medicine, University of California at San Francisco, San Francisco, California 15: University of Kansas School of Medicine, Wichita, Kansas 16: National Institute for Occupational Safety and Health, Washington, DC 17: University of Illinois College of Medicine, Rockford, Illinois; Source Info: May2005, Vol. 28 Issue 4, p403; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.amepre.2005.01.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16992917&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ellenberg, Susan S.
AU - Foulkes, Mary A.
AU - Midthun, Karen
AU - Goldenthal, Karen L.
T1 - Evaluating the Safety of New Vaccines: Summary of a Workshop.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005/05//
VL - 95
IS - 5
M3 - Article
SP - 800
EP - 807
PB - American Public Health Association
SN - 00900036
AB - Public concerns about the safety of vaccines arise on a regular basis. In November 2000, a workshop titled "Evaluation of New Vaccines: How Much Safety Data?" was convened by US Public Health Service agencies, including the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the Health Resources and Services Administration, to discuss appropriate methods for evaluating the safety of new vaccines. Workshop presentations addressed the current standards and approaches for new vaccine evaluation and postlicensure surveillance, as well as public views about vaccine safety and alternative approaches that could be considered. The advantages and disadvantages of conducting large controlled trials before licensure or widespread use of a new vaccine were discussed. We summarize these presentations and discussions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - GOVERNMENT agencies
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - NATIONAL Institutes of Health (U.S.)
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 16920408; Ellenberg, Susan S. 1; Email Address: sellenbe@cceb.upenn.edu Foulkes, Mary A. 2 Midthun, Karen 2 Goldenthal, Karen L. 2; Affiliation: 1: University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Division of Biostatistics, Blockley Hall, Room 611, 423 Guardian Dr, Philadelphia, PA 19104-6021 2: Center for Biologics Evaluation and Research, US Food and Drug Administration; Source Info: May2005, Vol. 95 Issue 5, p800; Subject Term: VACCINES; Subject Term: GOVERNMENT agencies; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration Company/Entity: NATIONAL Institutes of Health (U.S.) Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article; Full Text Word Count: 7868
L3 - 10.2105/AJPH.2004.039438
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16920408&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106647513
T1 - Public health matters. Evaluating the safety of new vaccines: summary of a workshop.
AU - Ellenberg SS
AU - Foulkes MA
AU - Midthun K
AU - Goldenthal KL
Y1 - 2005/05//
N1 - Accession Number: 106647513. Language: English. Entry Date: 20050617. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Clinical Trials -- Standards
KW - Drug Approval
KW - Patient Safety
KW - Public Health Administration
KW - Seminars and Workshops
KW - Vaccines -- Adverse Effects
KW - Vaccines -- Therapeutic Use
KW - Adverse Health Care Event
KW - Clinical Trials -- Evaluation
KW - Consumer Product Safety
KW - Drug Design
KW - Pharmacy and Pharmacology
KW - Public Opinion
SP - 800
EP - 807
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 95
IS - 5
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Public concerns about the safety of vaccines arise on a regular basis. In November 2000, a workshop titled 'Evaluation of New Vaccines: How Much Safety Data?' was convened by US Public Health Service agencies, including the Food and Drug Administration, the National Institutes of Health, the Centers for Disease Control and Prevention, and the Health Resources and Services Administration, to discuss appropriate methods for evaluating the safety of new vaccines.Workshop presentations addressed the current standards and approaches for new vaccine evaluation and postlicensure surveillance, as well as public views about vaccine safety and alternative approaches that could be considered.The advantages and disadvantages of conducting large controlled trials before licensure or widespread use of a new vaccine were discussed. We summarize these presentations and discussions.
SN - 0090-0036
AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Md
U2 - PMID: 15855455.
DO - 10.2105/AJPH.2004.039438
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106647513&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Fredy, J;
AU - Diggins, DA;
AU - Morrill, GB;
T1 - Blood pressure in native Americans switched from celecoxib to rofecoxib
CT - Blood pressure in native Americans switched from celecoxib to rofecoxib
JO - Annals of Pharmacotherapy (USA)
JF - Annals of Pharmacotherapy (USA)
Y1 - 2005/05/01/
VL - 39
IS - May
SP - 797
EP - 802
SN - 10600280
AD - Phoenix Indian Med Ctr, Dept Pharm, 4212 N 16th St, Phoenix, AZ 85016, USA dan.diggins@ihs.gov
N1 - Accession Number: 42-10285; Language: English; Chemical Name: Celecoxib--169590-42-5 Rofecoxib--186912-82-3; Therapeutic Class: (28:08.04); AHFS Class: Anti inflammatory agents Celecoxib (28:08.04); AHFS Class: Anti inflammatory agents Rofecoxib; References: 25; Journal Coden: APHRER; Human Indicator: Yes; Section Heading: Drug Evaluations; Toxicity
N2 - BACKGROUND: Nonsteroidal antiinflammatory drugs have been associated with exacerbation of hypertension. Differing effects on blood pressure (BP) have been reported in studies comparing celecoxib and rofecoxib. Concern regarding the cardiovascular safety of the cyclooxygenase-2 (COX-2) inhibitor class has intensified since the removal of rofecoxib from the market. OBJECTIVE: To evaluate the effect of a formulary change from celecoxib to rofecoxib on the BP of Native American patients at an Indian Health Service medical center. METHODS: Medical records of patients switched from celecoxib to rofecoxib were retrospectively reviewed. BP during the respective treatments was compared as follows: measurements recorded while taking celecoxib within 6 months before the index date and while taking rofecoxib from 1 week after the index date through 6 months of treatment were averaged. Differences in systolic and diastolic BP before and after the therapy change were evaluated using a paired Student's t-test. Subgroup analysis was performed for patients with preexisting hypertension. RESULTS: During rofecoxib therapy, the mean systolic BP was 2.9 mm Hg higher (p = 0.015) and the mean diastolic BP was 1.5 mm Hg higher (p = 0.042) than during celecoxib therapy. Among hypertensive patients, the respective mean systolic and diastolic BPs were 4.8 mm Hg (p = 0.009) and 2.0 mm Hg (p = 0.063) higher while taking rofecoxib. CONCLUSIONS: Switching patients from celecoxib to rofecoxib resulted in an increase in BP, with a larger difference observed in patients with hypertension. Future studies assessing the cardiovascular safety of currently marketed and investigational COX-2 inhibitors should evaluate the possible contribution of BP effects of these agents to overall risk.
KW - Celecoxib--therapeutic substitution-;
KW - Rofecoxib--therapeutic substitution-;
KW - Toxicity--celecoxib;
KW - Anti inflammatory agents--celecoxib;
KW - Hypertension--celecoxib;
KW - Hemodynamics--celecoxib;
KW - Toxicity--rofecoxib;
KW - Anti inflammatory agents--rofecoxib;
KW - Hypertension--rofecoxib;
KW - Hemodynamics--rofecoxib;
KW - Substitution--therapeutic;
KW - Ethnic groups--Native Americans;
KW - Outcomes--clinical;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Yong-Hak Kim
AU - Freeman, James P.
AU - Moody, Joanna D.
AU - Engesser, Karl-Heinrich
AU - Cerniglia, Carl E.
T1 - Effects of pH on the degradation of phenanthrene and pyrene byMycobacterium vanbaaleniiPYR-1.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2005/05//
VL - 67
IS - 2
M3 - Article
SP - 275
EP - 285
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - The effects of pH on the growth ofMycobacterium vanbaaleniiPYR-1 and its degradation of phenanthrene and pyrene were compared at pH 6.5 and pH 7.5. Various degradation pathways were proposed in this study, based on the identification of metabolites from mass and NMR spectral analyses. In tryptic soy broth,M. vanbaaleniiPYR-1 grew more rapidly at pH 7.5 (µ'=0.058 h-1) than at pH 6.5 (µ'=0.028 h-1). However, resting cells suspended in phosphate buffers with the same pH values displayed a shorter lag time for the degradation of phenanthrene and pyrene at pH 6.5 (6 h) than at pH 7.5 (48 h). The one-unit pH drop increased the degradation rates four-fold. Higher levels of both compounds were detected in the cytosol fractions obtained at pH 6.5. An acidic pH seemed to render the mycobacterial cells more permeable to hydrophobic substrates. The major pathways for the metabolism of phenanthrene and pyrene were initiated by oxidation at the K-regions. Phenanthrene-9,10- and pyrene-4,5-dihydrodiols were metabolized via transient catechols to the ring fission products, 2,2'-diphenic acid and 4,5-dicarboxyphenanthrene, respectively. The metabolic pathways converged to form phthalic acid. At pH 6.5,M. vanbaaleniiPYR-1 produced higher levels of theO-methylated derivatives of non-K-region phenanthrene- and pyrene-diols. Other non-K-region products, such ascis-4-(1-hydroxynaphth-2-yl)-2-oxobut-3-enoic acid, 1,2-dicarboxynaphthalene and benzocoumarin-like compounds, were also detected in the culture fluids. The non-K-region polycyclic aromatic hydrocarbon oxidation might be a significant burden to the cell due to the accumulation of toxic metabolites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anthracene
KW - Cyclopentaphenanthrene
KW - Phenanthrene
KW - Pyrene (Chemical)
KW - Mycobacterium
N1 - Accession Number: 16777935; Yong-Hak Kim 1; Freeman, James P. 2; Moody, Joanna D. 1; Engesser, Karl-Heinrich 3; Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA; 2: Division of Chemistry, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA; 3: Abteilung Biologische Abluftreinigung, ISWA, Universität Stuttgart, Bandtäle 2, Stuttgart, Germany; Issue Info: May2005, Vol. 67 Issue 2, p275; Thesaurus Term: Anthracene; Thesaurus Term: Cyclopentaphenanthrene; Subject Term: Phenanthrene; Subject Term: Pyrene (Chemical); Subject Term: Mycobacterium; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 11p; Illustrations: 2 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00253-004-1796-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16777935&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Timmerman, Michelle M.
AU - Shao, Jian Q.
AU - Apicella, Michael A.
T1 - Ultrastructural analysis of the pathogenesis ofNeisseria gonorrhoeaeendometrial infection.
JO - Cellular Microbiology
JF - Cellular Microbiology
Y1 - 2005/05//
VL - 7
IS - 5
M3 - Article
SP - 627
EP - 636
PB - Wiley-Blackwell
SN - 14625814
AB - We have studied gonococcal infection in human endometrium organ culture and in human primary endometrial epithelial cells using various microscopic techniques including scanning electron microscopy, transmission electron microscopy, bright field light microscopy and laser scanning confocal microscopy. Here we describe the interactions betweenNeisseria gonorrhoeaeand human endometrial luminal epithelial cells at the ultrastructural levels.N. gonorrhoeaeattached to cilia but were not observed associated with the plasma membrane of ciliated epithelial cells or internalized into ciliated epithelial cells.N. gonorrhoeaecould be found in intracellular vacuoles in secretory epithelial cells.N. gonorrhoeaehave diverse interactions with endometrial epithelium. These include intimate association and colocalization with asialoglycoprotein receptor (ASGP-R) and CEACAM, lamellipodia and ruffle formation and colocalization with CR3, and microvillus engagement. These studies indicate thatN. gonorrhoeaeutilize multiple mechanisms to associate with endometrial epithelial cells and can associate with both ciliated and secretory cells. This diversity is consistent with a role of the endometrium as a transition zone between frequently asymptomatic cervical gonorrhoea and symptomatic pelvic inflammatory disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOMETRIUM
KW - MUCOUS membrane
KW - ELECTRON microscopy
KW - CONFOCAL microscopy
KW - CELL membranes
KW - SEXUALLY transmitted diseases
N1 - Accession Number: 16702038; Timmerman, Michelle M. 1 Shao, Jian Q. 2 Apicella, Michael A. 2; Email Address: michael-apicella@uiowa.edu; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish PI HFV-140, Rockville MD 20855, USA. 2: The University of Iowa, Department of Microbiology, Iowa City, IA 52242, USA.; Source Info: May2005, Vol. 7 Issue 5, p627; Subject Term: ENDOMETRIUM; Subject Term: MUCOUS membrane; Subject Term: ELECTRON microscopy; Subject Term: CONFOCAL microscopy; Subject Term: CELL membranes; Subject Term: SEXUALLY transmitted diseases; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1462-5822.2005.00491.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Deschamps, P.
AU - Kulkarni, P.P.
AU - Gautam-Basak, M.
AU - Sarkar, B.
T1 - The saga of copper(II)–l-histidine
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
Y1 - 2005/05//
VL - 249
IS - 9/10
M3 - Article
SP - 895
EP - 909
SN - 00108545
AB - Abstract: Copper is an essential trace element required by all living organisms. Since the discovery in 1966 of copper(II)–l-histidine species in human blood, extensive research has been carried out to determine its role in copper transport. A small fraction of copper(II) bound to l-histidine maintains an exchangeable pool of copper(II) in equilibrium with albumin in human blood. The exchange of copper(II) between l-histidine and albumin modulates the availability of copper to the cell. The role of l-histidine during its interaction with copper(II)–albumin and in the cellular uptake of copper has generated considerable interest to determine the physico-chemical properties and the structure of physiological copper(II)–l-histidine complex. The structure of this complex remained inconclusive for the last four decades despite exhaustive characterization studies in aqueous solution. Recently, the physiological copper(II)–bis(l-histidinato) complex has been crystallized and the crystal structure has been solved. The structure shows a neutral five coordinate complex with a distorted square planar pyramidal geometry. The unique structural features explain its thermodynamic stability and kinetic reactivity. This review summarizes the overall perspectives encompassing copper(II)–l-histidine coordination chemistry and therapeutic applications of the physiological copper(II)–l-histidine complex. The copper(II)–l-histidine (1:2 complex at physiological pH) has been widely used in the treatment of Menkes disease (a genetic neurodegenerative disorder that leads to early death in the children due to impaired copper metabolism) and more recent use has been reported in the treatment of infantile hypertrophic cardioencephalomyopathy (a condition caused by mutations in SCO2, a cytochrome c oxidase assembly gene). [Copyright &y& Elsevier]
AB - Copyright of Coordination Chemistry Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COPPER
KW - ALBUMINS
KW - BLOOD
KW - AMINO acids
KW - Copper
KW - Copper transport
KW - Copper–albumin
KW - Copper–histidine
KW - Menkes disease
KW - X-ray structure
N1 - Accession Number: 16873252; Deschamps, P. 1 Kulkarni, P.P. 1 Gautam-Basak, M. 2 Sarkar, B. 1,3; Email Address: bsarkar@sickkids.ca; Affiliation: 1: Department of Structural Biology and Biochemistry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont., Canada M5G 1X8 2: Office of New Drug Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA 3: Department of Biochemistry, University of Toronto, Ont., Canada M5S 1A8; Source Info: May2005, Vol. 249 Issue 9/10, p895; Subject Term: COPPER; Subject Term: ALBUMINS; Subject Term: BLOOD; Subject Term: AMINO acids; Author-Supplied Keyword: Copper; Author-Supplied Keyword: Copper transport; Author-Supplied Keyword: Copper–albumin; Author-Supplied Keyword: Copper–histidine; Author-Supplied Keyword: Menkes disease; Author-Supplied Keyword: X-ray structure; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.ccr.2004.09.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burrows, Nilka Ríos
AU - Narva, Andrew S.
AU - Geiss, Linda S.
AU - Engelgau, Michael M.
AU - Acton, Kelly J.
T1 - End-Stage Renal Disease due to Diabetes Among Southwestern American Indians, 1990-2001.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2005/05//
VL - 28
IS - 5
M3 - Article
SP - 1041
EP - 1044
SN - 01495992
AB - OBJECTIVE -- This study assesses trends in the incidence of diabetes-related end-stage renal disease (ESRD) among southwestern American Indians (SWAIs). RESEARCH DESIGN AND METHODS -- Using the U.S. Renal Data System, we obtained the total number of new cases of treated ESRD in which diabetes was the primary cause of renal failure in 1990 through 2001 The incidence of diabetes-related ESRD was calculated using census population figures and estimates of the SWAI population with diabetes, then age-adjusted to the 2000 U.S. population. RESULTS -- Between 1990 and 2001, the annual number of new patients starting treatment for diabetes-related ESRD in the SWAI total population increased from 154 to 320, and the age-adjusted diabetes-related ESRD incidence per 10,000 population increased 34% (6.2-8.3 per 10,000 people). However, after adjusting for the increasing number of people with diabetes in the SWAI population between 1993 and 2001, the age-adjusted incidence of diabetes-related ESRD among SWAIs with diabetes decreased 31%, from 80.4 to 55.8 per 10,000 people with diabetes. It decreased for both sexes and in all age-groups. CONCLUSIONS -- The increasing incidence of diabetes-related ESRD in the SWAI population parallels the growing prevalence of diabetes. However, since 1993 diabetes-related ESRD incidence decreased in the SWAI population with diabetes, consistent with national trends. This may reflect the reduction in risk factors and improvements in diabetes care practices in Indian communities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - CHRONIC kidney failure
KW - KIDNEY diseases
KW - DIABETICS
KW - POPULATION
KW - MEDICAL care
N1 - Accession Number: 17018501; Burrows, Nilka Ríos 1,2; Email Address: nrios@cdc.gov Narva, Andrew S. 3 Geiss, Linda S. 1 Engelgau, Michael M. 1 Acton, Kelly J. 2; Affiliation: 1: Epidemiology and Statistics Branch, Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Division of Diabetes Treatment and Prevention, Indian Health Service, Albuquerque, New Mexico 3: Kidney Disease Program, Indian Health Service, Albuquerque, New Mexico; Source Info: May2005, Vol. 28 Issue 5, p1041; Subject Term: DIABETES; Subject Term: CHRONIC kidney failure; Subject Term: KIDNEY diseases; Subject Term: DIABETICS; Subject Term: POPULATION; Subject Term: MEDICAL care; Number of Pages: 4p; Illustrations: 3 Graphs; Document Type: Article; Full Text Word Count: 3072
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johann-Liang, Rosemary
AU - James, Andrea N.
AU - Behr, Virginia L.
AU - Struble, Kimberly
AU - Birnkrant, Debra B.
T1 - Reporting of Deaths During Pre-Approval Clinical Trials for Advanced HIV-Infected Populations.
JO - Drug Safety
JF - Drug Safety
Y1 - 2005/05//
VL - 28
IS - 7
M3 - Article
SP - 559
EP - 564
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - The Division of Antiviral Drug Products of the US FDA has regulatory authority over the investigational new drugs under development by various sponsors to treat HIV-infected populations. The FDA and the sponsors of investigational new drugs use the Code of Federal Regulations to guide the entire drug development process, in order to ensure that safe and efficacious drugs are brought to market. To achieve this goal, diligent monitoring for safety during the pre-approval phase of new drug development is particularly crucial. When deciding what adverse experiences on clinical trials should be expeditiously reported, the Division recommends a conservative interpretation of the Code of Federal Regulations, where an adverse experience in a clinical trial of advanced HIV-infected patients is considered to be ‘associated with the use of the drug’ when the relationship cannot be ruled out with objective evidence. Fatal adverse experiences for subjects on clinical trials should be especially scrutinised. Safety reporting should be expedited when death occurs during clinical trials of advanced HIV-infected populations. The three components of an expedited reportable death occurrence, namely ‘serious’, ‘unexpected’ and ‘associated with the drug use’ as they relate to advanced HIV-infected populations, are discussed in this article. An occurrence of death is by definition serious. Unexpected experiences are unlisted adverse experiences, but need to be put into the context of specificity and severity. ‘Associated with the drug use’ has been clarified as ‘relationship to the drug cannot be ruled out’. Because death in the advanced HIV-infected/AIDS population is usually a complex event, the possible contribution of the study drug is difficult to rule out. Thus, if the three components of the reporting requirement are met or insufficient information is available to make a firm determination of causality by the seventh day of the reporting period, the Division of Antiviral Drug Products expects expedited death reports on subjects participating in investigational new drug clinical studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - HIV-positive persons
KW - CLINICAL trials
KW - AIDS (Disease)
KW - ANTIVIRAL agents
KW - PATIENTS
KW - Adverse reaction monitoring
KW - Death
KW - HIV infections
N1 - Accession Number: 17364574; Johann-Liang, Rosemary 1 James, Andrea N. 1 Behr, Virginia L. 1 Struble, Kimberly 1 Birnkrant, Debra B. 1; Affiliation: 1: Division of Antiviral Drug Products, Center for Drug Evaluation and Research, The US Food and Drug Administration, Rockville, Maryland, USA.; Source Info: 2005, Vol. 28 Issue 7, p559; Subject Term: DRUGS; Subject Term: HIV-positive persons; Subject Term: CLINICAL trials; Subject Term: AIDS (Disease); Subject Term: ANTIVIRAL agents; Subject Term: PATIENTS; Author-Supplied Keyword: Adverse reaction monitoring; Author-Supplied Keyword: Death; Author-Supplied Keyword: HIV infections; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carreón, Tania
AU - Butler, Mary Ann
AU - Ruder, Avima M.
AU - Waters, Martha A.
AU - Davis-King, Karen E.
AU - Calvert, Geoffrey M.
AU - Schulte, Paul A.
AU - Connally, Barbara
AU - Ward, Elizabeth M.
AU - Sanderson, Wayne T.
AU - Heineman, Ellen F.
AU - Mandel, Jack S.
AU - Morton, Roscoe F.
AU - Reding, Douglas J.
AU - Rosenman, Kenneth D.
AU - Talaska, Glenn
T1 - Gliomas and Farm Pesticide Exposure in Women: The Upper Midwest Health Study.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/05//
VL - 113
IS - 5
M3 - Article
SP - 546
EP - 551
PB - Superintendent of Documents
SN - 00916765
AB - An excess incidence of brain cancer in male farmers has been noted in several studies, but few studies have focused on women. The National Institute for Occupational Safety and Health Upper Midwest Health Study evaluated effects of rural exposures for 341 female glioma cases and 528 controls, all adult (18-80 years of age) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. On average, controls lived longer on farms than did cases. After adjusting for age, age group, education, and farm residence, no association with glioma was observed for exposure to arsenicals, benzoic acids, carbamates, chloroacetanilides, dinitroanilines, inorganics, organochlorines, organophosphates, phenoxys, triazines, or urea-based or estrogenic pesticides. An increased risk of glioma was observed for carbamate herbicides but was not statistically significant (odds ratio = 3.0; 95% confidence interval, 0.9-9.5). No association was observed between glioma and exposure to 12 widely used specific pesticides, after adjustment for age, age group, education, and any other pesticide exposure. These results were not affected after exclusion of proxy respondents (43% of cases, 2% of controls). Women were less likely than men to have applied pesticides, but more likely to have laundered pesticide-contaminated clothes. Storing pesticides in the house was associated with a statistically non-significant increased risk. Results show that exposure to pesticides was not associated with an increased risk of intracranial gliomas in women. Other farm-related factors could be etiologic factors and will be discussed in future reports. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural chemicals
KW - Pesticides
KW - DISEASES
KW - Gliomas
KW - Nervous system -- Tumors
KW - Cancer in women -- Risk factors
KW - Women
KW - brain cancer
KW - case-control
KW - farmers
KW - glioma
KW - Midwest
KW - pesticides
KW - women
N1 - Accession Number: 17315959; Carreón, Tania 1; Email Address: carreota@ucmail.uc.edu; Butler, Mary Ann 1; Ruder, Avima M. 1; Waters, Martha A. 1; Davis-King, Karen E. 1; Calvert, Geoffrey M. 1; Schulte, Paul A. 1; Connally, Barbara 1; Ward, Elizabeth M. 1; Sanderson, Wayne T. 1; Heineman, Ellen F. 2; Mandel, Jack S. 3; Morton, Roscoe F. 4; Reding, Douglas J. 5; Rosenman, Kenneth D. 6; Talaska, Glenn 7; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA; 3: School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA; 4: Mercy Foundation, Des Moines, Iowa, USA; 5: Natural Farm Medicine Center, Marshfield Clinic, Marshfield, Wisconsin, USA; 6: Department of Medicine, Michigan State University, East Lansing, Michigan, USA; 7: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA; Issue Info: May2005, Vol. 113 Issue 5, p546; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Pesticides; Thesaurus Term: DISEASES; Subject Term: Gliomas; Subject Term: Nervous system -- Tumors; Subject Term: Cancer in women -- Risk factors; Subject Term: Women; Author-Supplied Keyword: brain cancer; Author-Supplied Keyword: case-control; Author-Supplied Keyword: farmers; Author-Supplied Keyword: glioma; Author-Supplied Keyword: Midwest; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: women; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.7456
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rao, K. Murali Krishna
AU - Ma, Jane Y. C.
AU - Meighan, Terence
AU - Barger, Mark W.
AU - Pack, Donna
AU - Vallyathan, Val
T1 - Time Course of Gene Expression of Inflammatory Mediators in Rat Lung after Diesel Exhaust Particle Exposure.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/05//
VL - 113
IS - 5
M3 - Article
SP - 612
EP - 617
PB - Superintendent of Documents
SN - 00916765
AB - Diesel exhaust particles (DEPs) at three concentrations (5, 35, and 50 mg/kg body weight) were instilled into rats intratracheally. We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in lung tissue. Using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), we measured the mRNA levels of eight genes [interleukin (IL)-1β, IL-6, IL-10, iNOS (inducible nitric oxide synthase), MCP-1 (monocyte chemoattractant protein-1), MIP-2 (macrophage inflammatory protein-2), TGF-β1 (transforming growth factor-β1), and TNF-α (tumor necrosis factor-α)] in BAL cells and four genes [IL-6, ICAM-1 (intercellular adhesion molecule-1), GM-CSF (granulocyte/macrophage-colony stimulating factor), and RANTES (regulated upon activation normal T cell expressed and secreted)] in lung tissue. In BAL cells on day 1, high-dose exposure induced a significant up-regulation of IL-1β, iNOS, MCP-1, and MIP-2 but no change in IL-6, IL-10, TGF-β1, and TNF-α mRNA levels. There was no change in the mRNA levels of IL-6, RANTES, ICAM-1, and GM-CSF in lung tissue. Nitric oxide production and levels of MCP-1 and MIP-2 were increased in the 24-hr culture media of alveolar macrophages (AMs) obtained on day 1. IL-6, MCP-1, and MIP-2 levels were also elevated in the BAL fluid. BAL fluid also showed increases in albumin and lactate dehydrogenase. The cellular content in BAL fluid increased at all doses and at all time periods, mainly due to an increase in polymorphonuclear leukocytes. In vitro studies in AMs and cultured lung fibroblasts showed that lung fibroblasts are a significant source of IL-6 and MCP-1 in the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel motor exhaust gas -- Environmental aspects
KW - Air pollution
KW - Pollution
KW - Chemokines
KW - Cytokines
KW - Inflammation -- Mediators
KW - Macrophages
KW - Gene expression
KW - chemokines
KW - diesel
KW - lung
KW - molecular biology
KW - monocyte/macrophage
N1 - Accession Number: 17316618; Rao, K. Murali Krishna 1; Email Address: mir8@cdc.gov; Ma, Jane Y. C. 1; Meighan, Terence 1; Barger, Mark W. 1; Pack, Donna 1; Vallyathan, Val 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mrgantown, West Virginia, USA; Issue Info: May2005, Vol. 113 Issue 5, p612; Thesaurus Term: Diesel motor exhaust gas -- Environmental aspects; Thesaurus Term: Air pollution; Thesaurus Term: Pollution; Subject Term: Chemokines; Subject Term: Cytokines; Subject Term: Inflammation -- Mediators; Subject Term: Macrophages; Subject Term: Gene expression; Author-Supplied Keyword: chemokines; Author-Supplied Keyword: diesel; Author-Supplied Keyword: lung; Author-Supplied Keyword: molecular biology; Author-Supplied Keyword: monocyte/macrophage; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.7696
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17316618&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fu, Xin
AU - Latendresse, John R.
AU - Muskhelishvili, Levan
AU - Blaydes, Betty S.
AU - Delclos, K. Barry
T1 - Dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/05//
VL - 43
IS - 5
M3 - Article
SP - 765
EP - 774
SN - 02786915
AB - Abstract: In this study, dietary modulation of 7,12-dimethylbenz[a]anthracene (DMBA)-induced adrenal toxicity in rats was investigated. Beginning at postnatal day (PND) 21, female Sprague-Dawley rats were fed either soy-containing NIH-31 diet or soy- and alfalfa-free 5K96 diet. On the first day of diestrus when the animals were PND 50±5, rats received either an oral dose of 80 mg/kg DMBA or sesame oil, the vehicle, and were sacrificed at 24, 36, or 48 h after treatment. Apoptosis was manifested at 24 and 36 h after DMBA treatment in the zona reticularis (ZR) and the zona fasciculata (ZF) of the adrenal cortex; this was followed by severe hemorrhagic necrosis at 48 h. DMBA-induced apoptosis, evaluated by the TUNEL assay, immunohistochemical analysis of activated caspase 3, and the ratio of expression of pro-apoptotic Bax to anti-apoptotic Bcl2, was greater in rats fed NIH-31 diet relative to rats fed 5K96 diet at 24 h after treatment. Four of six DMBA-treated rats fed 5K96 diet had severe adrenal necrosis by 48 h, whereas this lesion was present in only two of six DMBA-treated rats fed NIH-31 diet. DMBA also caused a significant decrease of serum corticosterone relative to controls at 48 h in rats fed 5K96 diet. The present study indicated that diet modulates DMBA-induced adrenal toxicity in female rats, with increased apoptosis early and reduced necrosis later in rats fed a soy-containing diet. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - ADRENAL cortex
KW - RATS
KW - APOPTOSIS
KW - CELL death
KW - ACTH, adrenocorticotropin
KW - Adrenal toxicity
KW - Apoptosis
KW - CYP, cytochrome P450
KW - DAB, Diaminobenzidine
KW - Diet
KW - DMBA
KW - DMBA, 7,12-dimethylbenz[a]anthracene
KW - ER, Estrogen receptor
KW - H&E, Hematoxylin and eosin
KW - PND, postnatal day
KW - SD, Standard deviation
KW - Soy
KW - TUNEL, Terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling
KW - ZF, Zona fasciculate
KW - ZR, Zona reticularis
N1 - Accession Number: 17515912; Fu, Xin 1; Email Address: xfu@nctr.fda.gov Latendresse, John R. 2 Muskhelishvili, Levan 2 Blaydes, Betty S. 1 Delclos, K. Barry 1; Email Address: bdelclos@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Pathology Services, Charles River Laboratories, Jefferson, AR 72079, USA; Source Info: May2005, Vol. 43 Issue 5, p765; Subject Term: TOXICOLOGY; Subject Term: ADRENAL cortex; Subject Term: RATS; Subject Term: APOPTOSIS; Subject Term: CELL death; Author-Supplied Keyword: ACTH, adrenocorticotropin; Author-Supplied Keyword: Adrenal toxicity; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: CYP, cytochrome P450; Author-Supplied Keyword: DAB, Diaminobenzidine; Author-Supplied Keyword: Diet; Author-Supplied Keyword: DMBA; Author-Supplied Keyword: DMBA, 7,12-dimethylbenz[a]anthracene; Author-Supplied Keyword: ER, Estrogen receptor; Author-Supplied Keyword: H&E, Hematoxylin and eosin; Author-Supplied Keyword: PND, postnatal day; Author-Supplied Keyword: SD, Standard deviation; Author-Supplied Keyword: Soy; Author-Supplied Keyword: TUNEL, Terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling; Author-Supplied Keyword: ZF, Zona fasciculate; Author-Supplied Keyword: ZR, Zona reticularis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.fct.2005.01.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tanaka, Toru
AU - Nakamura, Hajime
AU - Yodoi, Junji
AU - Bloom, Eda T.
T1 - Redox regulation of the signaling pathways leading to eNOS phosphorylation
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2005/05//
VL - 38
IS - 9
M3 - Article
SP - 1231
EP - 1242
SN - 08915849
AB - Abstract: Oxidative stress mediates positive and negative effects on physiological processes. Recent reports show that H2O2 induces phosphorylation and activation of endothelial nitric oxide synthase (eNOS) through an Akt-phosphorylation-dependent pathway. In this study, we assessed activation of eNOS and Akt by determining their phosphorylation status. Whereas moderate levels of H2O2 (100 μM) activated the Akt/eNOS pathway, higher levels (500 μM) did not, suggesting differential effects by differing levels of oxidative stress. We then found that two pro-oxidants with activity on sulfhydryl groups, 1-chloro-2,4-dinitrobenzene (CDNB) and diethyl maleate (DEM), blocked the phosphorylation events induced by 100 μM H2O2. GSH was not a target thiol in this system because buthionine sulfoximine did not inhibit this phosphorylation. However, down-regulation of cell membrane surface and intracellular free thiols was associated with the inhibition of phosphorylation, suggesting that oxidation of non-GSH thiols inhibits the H2O2-induced phosphorylation of eNOS and Akt. DTT reversed the inhibitory effects of CDNB and DEM on Akt phosphorylation and concomitantly restored cell surface thiol levels more efficiently than it restored intracellular thiols, suggesting a more prominent role for the former. Similarly, DEM and CDNB inhibited TNF-α-induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways. Our findings suggest that eNOS activation is exquisitely sensitive to regulation by redox and that cell surface thiols, other than glutathione, regulate signal transduction leading to phosphorylation of Akt and eNOS. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATION-reduction reaction
KW - PHOSPHORYLATION
KW - NITRIC oxide
KW - ENDOTHELIUM
KW - 1-chloro-2
KW - 1-chloro-2,4-dinitrobenzene (CDNB)
KW - 2′
KW - 2′,7′-dichlorofluorescein diacetate (DCFH-DA)
KW - 4-dinitrobenzene (CDNB)
KW - 5
KW - 5′-dithiobis-2-nitrobenzonic acid (DTNB)
KW - 5,5′-dithiobis-2-nitrobenzonic acid (DTNB)
KW - 5-chloromethylfluorescein diacetate (CMFDA)
KW - 7′-dichlorofluorescein diacetate (DCFH-DA)
KW - Akt
KW - Alexa-maleimide (ALM)
KW - bovine aortic endothelial cells (BAEC)
KW - buthionine sulfoximine (BSO)
KW - cell membrane surface thiols (cms-SH)
KW - diethyl maleate (DEM)
KW - Endothelial cells
KW - endothelial NOS (eNOS)
KW - Free radicals
KW - interleukin (IL)
KW - intracellular thiols (ic-SH)
KW - natural killer (NK)
KW - Nitric oxide synthase
KW - nitric oxide synthase (NOS)
KW - phosphatidylinositol 3-kinase (PI3-K)
KW - porcine aortic endothelial cells (PAEC)
KW - reduced type glutathione (GSH)
KW - Signal transduction
KW - Thiols
KW - thioredoxin (TRX)
KW - Xenotransplantation
N1 - Accession Number: 16873793; Tanaka, Toru 1 Nakamura, Hajime 2 Yodoi, Junji 2,3 Bloom, Eda T. 1; Email Address: bloom@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center of Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan 3: Department of Biological Responses, Institute of Virus Research, Kyoto University, Kyoto, Japan; Source Info: May2005, Vol. 38 Issue 9, p1231; Subject Term: OXIDATION-reduction reaction; Subject Term: PHOSPHORYLATION; Subject Term: NITRIC oxide; Subject Term: ENDOTHELIUM; Author-Supplied Keyword: 1-chloro-2; Author-Supplied Keyword: 1-chloro-2,4-dinitrobenzene (CDNB); Author-Supplied Keyword: 2′; Author-Supplied Keyword: 2′,7′-dichlorofluorescein diacetate (DCFH-DA); Author-Supplied Keyword: 4-dinitrobenzene (CDNB); Author-Supplied Keyword: 5; Author-Supplied Keyword: 5′-dithiobis-2-nitrobenzonic acid (DTNB); Author-Supplied Keyword: 5,5′-dithiobis-2-nitrobenzonic acid (DTNB); Author-Supplied Keyword: 5-chloromethylfluorescein diacetate (CMFDA); Author-Supplied Keyword: 7′-dichlorofluorescein diacetate (DCFH-DA); Author-Supplied Keyword: Akt; Author-Supplied Keyword: Alexa-maleimide (ALM); Author-Supplied Keyword: bovine aortic endothelial cells (BAEC); Author-Supplied Keyword: buthionine sulfoximine (BSO); Author-Supplied Keyword: cell membrane surface thiols (cms-SH); Author-Supplied Keyword: diethyl maleate (DEM); Author-Supplied Keyword: Endothelial cells; Author-Supplied Keyword: endothelial NOS (eNOS); Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: interleukin (IL); Author-Supplied Keyword: intracellular thiols (ic-SH); Author-Supplied Keyword: natural killer (NK); Author-Supplied Keyword: Nitric oxide synthase; Author-Supplied Keyword: nitric oxide synthase (NOS); Author-Supplied Keyword: phosphatidylinositol 3-kinase (PI3-K); Author-Supplied Keyword: porcine aortic endothelial cells (PAEC); Author-Supplied Keyword: reduced type glutathione (GSH); Author-Supplied Keyword: Signal transduction; Author-Supplied Keyword: Thiols; Author-Supplied Keyword: thioredoxin (TRX); Author-Supplied Keyword: Xenotransplantation; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2005.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16873793&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, Gerald R.
T1 - Progress in Medical Ultrasound Exposimetry.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2005/05//
VL - 52
IS - 5
M3 - Article
SP - 717
EP - 736
SN - 08853010
AB - Biomedical applications of ultrasound have experienced tremendous growth over the past 50 years. Early work in thermal therapy and surgery soon was followed by diagnostic imaging and Doppler. Because patient safety was an important issue from the beginning, the study of methods for measuring exposure levels, and their relationship to possible biological effects, paralleled the growth of the various therapeutic and diagnostic techniques. The diverse conditions of use have presented a range of exposure measurement challenges, and the sensors and techniques used to evaluate ultrasound fields have had to evolve as new or expanded clinical applications have emerged. In this paper some of the more notable of these developments are presented and discussed. Topics covered include devices and techniques, methods of calibration, progress in standardization, and current problem areas, including the effects of nonlinear propagation. Some early methods are described, but emphasis is given to more recent work applicable to present and future uses of ultrasound in medicine and biology. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC imaging
KW - IMAGING systems in medicine
KW - MEASURING instruments
KW - DIAGNOSTIC ultrasonic imaging
KW - ULTRASONICS in medicine
KW - ULTRASONICS in biology
N1 - Accession Number: 17426881; Harris, Gerald R. 1; Email Address: grh@cdrh.fda.gov; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20850; Source Info: May2005, Vol. 52 Issue 5, p717; Subject Term: ULTRASONIC imaging; Subject Term: IMAGING systems in medicine; Subject Term: MEASURING instruments; Subject Term: DIAGNOSTIC ultrasonic imaging; Subject Term: ULTRASONICS in medicine; Subject Term: ULTRASONICS in biology; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 20p; Illustrations: 3 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keane, Michael
AU - Wallace, William
T1 - A Quantitative In Vitro Fluorescence Imaging Method for Phospholipid Loss from Respirable Mineral Particles.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2005/05//
VL - 17
IS - 6
M3 - Article
SP - 287
EP - 292
PB - Taylor & Francis Ltd
SN - 08958378
AB - Respirable quartz and kaolin particles were treated with fluorescent-labeled phospholipids to model contact of fibrogenic and nonfibrogenic particles with pulmonary surfactant in the alveolar regions of the lung. Particles were used to challenge rat pulmonary macrophages in vitro at times from 1 d to 10 d. The objective was to develop a quantitative method to track surfactant components that adsorb to respirable particles in the lung or inside cells. Confocal laser scanning microscopy was used to image and quantify surfactant remaining on particles internalized by cells. Results indicate that the fluorescent label is removed from quartz particles quickly, with the fluorescence intensity less than 15% of initial value at 3 d, and about 5% at 10 d. In contrast, the kaolin particle-associated fluorescence was still ~39% of initial intensity at 3 d, and 10–15% at 10 d. Unchallenged cells showed a background of ~5%, and noninternalized particles did not exhibit any loss of fluorescence over the 10-d exposure. The results indicate the method may be useful in label-removal rate studies of respirable particles in vitro, with some cautions and limitations. Results are discussed and compared with similar studies using nonimaging techniques. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINERALS
KW - FLUORESCENCE
KW - PHOSPHOLIPIDS
KW - CELLS
KW - QUANTITATIVE research
KW - SURFACE active agents
N1 - Accession Number: 16668574; Keane, Michael 1; Email Address: mjk3@cdc.gov Wallace, William 1; Affiliation: 1: National Institute for Occupational Safety and Health Health Effects Laboratory Division Morgantown West Virginia USA; Source Info: May2005, Vol. 17 Issue 6, p287; Subject Term: MINERALS; Subject Term: FLUORESCENCE; Subject Term: PHOSPHOLIPIDS; Subject Term: CELLS; Subject Term: QUANTITATIVE research; Subject Term: SURFACE active agents; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/08958370590922571
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobson-Kram, David
AU - Jacobs, Abigail
T1 - Use of Genotoxicity Data to Support Clinical Trials or Positive Genetox Findings on a Candidate Pharmaceutical or Impurity .... Now What?
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2005/05//May/Jun2005
VL - 24
IS - 3
M3 - Article
SP - 129
EP - 134
PB - Taylor & Francis Ltd
SN - 10915818
AB - Results from carcinogenicity studies are generally not available for drugs until the time of approval. Many people, including healthy volunteers are often exposed to pharmacologically active doses of the drug before carcinogenicity results are available. The Food and Drug Administration (FDA) Center for Drug Evaluation and Research uses results of genetic toxicology studies as a surrogate for carcinogenicity during the drug development phase (clinical trials). A number of issues are considered in deciding whether drugs that give positive results in genetic toxicology studies can be given to subjects in clinical trials. These relate to the drug indication, the target population, duration of treatment, and importance of the drug. In general, single-dose clinical studies are permitted regardless of the genetox results. In situations where a genetic toxicology assay showed a positive result, some review divisions have asked sponsors to perform a Syrian hamster embryo (SHE) cell transformation assay or a p53 carcinogenicity study prior to allowing repeat-dose clinical trials to proceed. This paper discusses alternatives to SHE cell and p53 assays when faced with a positive result in a genetic toxicology assay. In addition, this paper discusses factors to consider when setting limits for genotoxic impurities in drug substances and products. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Carcinogenicity
KW - Pharmacology
KW - Clinical drug trials
KW - Clinical trials
KW - Medical research
KW - Clinical Trials
KW - Genotoxic Impurities
KW - Genotoxicity
KW - Pharmaceutical Safety
KW - Weight-of-Evidence
N1 - Accession Number: 17718076; Jacobson-Kram, David 1; Jacobs, Abigail 1; Email Address: jacobsonkram@cder.fda.gov; Affiliations: 1: Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.; Issue Info: May/Jun2005, Vol. 24 Issue 3, p129; Thesaurus Term: Genetic toxicology; Thesaurus Term: Carcinogenicity; Thesaurus Term: Pharmacology; Subject Term: Clinical drug trials; Subject Term: Clinical trials; Subject Term: Medical research; Author-Supplied Keyword: Clinical Trials; Author-Supplied Keyword: Genotoxic Impurities; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Pharmaceutical Safety; Author-Supplied Keyword: Weight-of-Evidence; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/10915810590952933
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leighton, John K.
T1 - Application of Emerging Technologies in Toxicology and Safety Assessment: Regulatory Perspectives.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2005/05//May/Jun2005
VL - 24
IS - 3
M3 - Article
SP - 153
EP - 155
PB - Taylor & Francis Ltd
SN - 10915818
AB - Emerging technologies applied in the regulatory field encompass a group of technologies that are used in addition to or in replacement of the standard toxicology studies conducted to support an Investigational New Drug Application (IND) or New Drug Application (NDA). The standard package includes general toxicology studies of various duration, safety pharmacology studies, genetic toxicology studies, and reproductive toxicology studies. New and emerging technologies applied to the regulation of new drugs include the use of novel biomarkers, transfected cells and transgenic animals, and the “omics” technologies (toxicogenomics, proteomics, and metabonomics). These technologies are at various stages of regulatory development and acceptance. For example, the use of transgenic animals have gained acceptance by regulatory authorities to replace a 2-year carcinogenicity assay. Alternatively, the “omics” technologies are not sufficiently advanced to achieve regulatory acceptance as replacements, although these assays have a role early in drug development and they may prove useful as supplements to standard studies. Data from these assays have been used to address specific mechanistic questions in combination with standard toxicology assays. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Technology
KW - Pharmacology
KW - Genetic toxicology
KW - Biochemical markers
KW - Transgenic animals
KW - Biomarkers
KW - Carcinogenicity Assessment
KW - Critical Path
KW - Toxicogenomics
KW - Transgenic Animals
N1 - Accession Number: 17718082; Leighton, John K. 1; Email Address: LEIGHTONJ@cder.fda.gov; Affiliations: 1: Division of Oncology Drug Products, Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, Maryland, USA.; Issue Info: May/Jun2005, Vol. 24 Issue 3, p153; Thesaurus Term: Toxicology; Thesaurus Term: Technology; Thesaurus Term: Pharmacology; Thesaurus Term: Genetic toxicology; Thesaurus Term: Biochemical markers; Thesaurus Term: Transgenic animals; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Carcinogenicity Assessment; Author-Supplied Keyword: Critical Path; Author-Supplied Keyword: Toxicogenomics; Author-Supplied Keyword: Transgenic Animals; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10915810590948352
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hwang, Dae Y.
AU - Cho, Jung S.
AU - Oh, Jae H.
AU - Shim, Sun B.
AU - Jee, Seung W.
AU - Lee, Su H.
AU - Seo, Su J.
AU - Kang, Hyun G.
AU - Sheen, Yhun Y.
AU - Lee, Seok H.
AU - Kim, Yong K.
T1 - An In Vivo Bioassay for Detecting Antiandrogens Using Humanized Transgenic Mice Coexpressing the Tetracycline-Controlled Transactivator and Human CYP1B1 Gene.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2005/05//May/Jun2005
VL - 24
IS - 3
M3 - Article
SP - 157
EP - 164
PB - Taylor & Francis Ltd
SN - 10915818
AB - The typical strategy used in analysis of antiandrogens involves the morphological changes of a marker in castrated rats Hershberger assay for the prostate, seminal vesicle, levator ani plus bulbocavernosus muscles (LABC), Cowper's gland, and glans penis. However, there are disadvantages to this approach, such as the time required, and the results may not correspond to those in actual human exposure. To evaluate its ability for detecting antiandrogens, in vivo the dose effect of di-(2-ethylhexyl) phthalate (DEHP) and time effect of five antiandrogens, DEHP, di-n-butyl phthalate (DBP), diethyl phthalate (DEP), linuron (3-(4-dichlorophenyl)-methoxy-1-methylurea), and 2,4 ′ -DDE (1,1-dichloro-2-( p -chlorophenyl)-2-( o -chlorophenyl)ethylene), were investigated using humanized transgenic mice coexpressing tetracycline-controlled transactivator (tTA) and the human cytochrome P450 (CYP) enzyme CYP1B1 (hCYP1B1). Adult transgenic males were treated with each of the five antiandrogens, and their tTA-driven hCYP1B1 expressions analyzed by real-time polymerase chain reaction (PCR) and/or Western blot and for O-debenzylation activity. Herein, the treatments of adult males with the five antiandrogens were shown to affect the increased levels of tTA-driven hCYP1B1 expression in both dose-dependent and repeated experiments. Thus, this novel in vivo bioassay, using humanized transgenic mice, is useful for measuring antiandrogens, and is a means to a more relevant bioassay relating to actual human exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological assay
KW - Antiandrogens
KW - Antimetabolites
KW - Hormone antagonists
KW - Steroid drugs
KW - Transgenic mice
KW - DNA polymerases
KW - Androgen
KW - Antiandrogen
KW - CYP1B1
KW - CYPlBl
KW - Tetracycline
KW - Transgenic
N1 - Accession Number: 17718078; Hwang, Dae Y. 1; Cho, Jung S. 1; Oh, Jae H. 1; Shim, Sun B. 1; Jee, Seung W. 1; Lee, Su H. 1; Seo, Su J. 1; Kang, Hyun G. 2; Sheen, Yhun Y. 3; Lee, Seok H. 4; Kim, Yong K. 1; Email Address: kimyongkyu@hanmail.net; Affiliations: 1: Division of Laboratory Animal Resources, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul, Korea; 2: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Chongju, Korea; 3: College of Pharmacy, Ewha Womans University, Seoul, Korea; 4: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Issue Info: May/Jun2005, Vol. 24 Issue 3, p157; Thesaurus Term: Biological assay; Subject Term: Antiandrogens; Subject Term: Antimetabolites; Subject Term: Hormone antagonists; Subject Term: Steroid drugs; Subject Term: Transgenic mice; Subject Term: DNA polymerases; Author-Supplied Keyword: Androgen; Author-Supplied Keyword: Antiandrogen; Author-Supplied Keyword: CYP1B1; Author-Supplied Keyword: CYPlBl; Author-Supplied Keyword: Tetracycline; Author-Supplied Keyword: Transgenic; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10915810590948370
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hillier, Sharon L.
AU - Moench, Thomas
AU - Shattock, Robin
AU - Black, Roberta
AU - Reichelderfer, Patricia
AU - Veronese, Fulvia
T1 - In Vitro and In Vivo.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/05//5/1/2005
VL - 38
IS - 1
M3 - Article
SP - 1
EP - 8
SN - 15254135
AB - Discusses the in vitro,ex vivo and animal model data on the safety of N-9, a nonionic surfactant for use in the prevention of sexually transmitted diseases. Attribution of the spermicidal action of N-9; Evaluation of a vaginal gel formulation for efficacy in prevention of HIV infection; Assessment of predictive value in relation to the clinical outcome.
KW - PREVENTIVE medicine
KW - SEXUALLY transmitted diseases
KW - HIV infections
KW - SURFACE active agents
KW - SEXUAL health
KW - COMMUNICABLE diseases
KW - acquisition
KW - HIV
KW - microbicide
KW - Nonoxynol-9
KW - prevention
KW - sexually transmitted infection
KW - transmission
KW - women
N1 - Accession Number: 16963959; Hillier, Sharon L. 1 Moench, Thomas 2 Shattock, Robin 3 Black, Roberta 4 Reichelderfer, Patricia 4 Veronese, Fulvia 4; Email Address: FV10X@nih.gov; Affiliation: 1: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 2: ReProtect, Baltimore, MD 3: Department of Infectious Diseases, St. Georges Medical School, University of London, London, England 4: National Institutes of Health, US Department of Health and Human Services, Bethesda, MD; Source Info: 5/1/2005, Vol. 38 Issue 1, p1; Subject Term: PREVENTIVE medicine; Subject Term: SEXUALLY transmitted diseases; Subject Term: HIV infections; Subject Term: SURFACE active agents; Subject Term: SEXUAL health; Subject Term: COMMUNICABLE diseases; Author-Supplied Keyword: acquisition; Author-Supplied Keyword: HIV; Author-Supplied Keyword: microbicide; Author-Supplied Keyword: Nonoxynol-9; Author-Supplied Keyword: prevention; Author-Supplied Keyword: sexually transmitted infection; Author-Supplied Keyword: transmission; Author-Supplied Keyword: women; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ehlers, James
AU - Palermo, Teri
T1 - Community Partners for Healthy Farming Intervention Research.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2005/05//
VL - 11
IS - 2
M3 - Article
SP - 193
EP - 203
SN - 10747583
AB - Focuses on the Community Partners for Healthy Farming Intervention Research (CPHF-IR) program in the U.S. Goal of implementing and evaluating interventions for reduction of agriculture-related injuries, hazards and illnesses; Development of active partnerships between researchers, communities, workers, managers, agricultural organizations, agribusinesses and other stakeholders; Feasibility of Latino lay health advisors as active partners in research; Introduction of public health in social studies and language classes.
KW - Agricultural industries
KW - Rural development
KW - Industrial safety
KW - Public health
KW - Agriculture
KW - United States
KW - Community-based
KW - Ergonomics
KW - Farm worker
KW - Farmer
KW - Intervention research
KW - Participatory research
N1 - Accession Number: 16964036; Ehlers, James 1; Email Address: jehlers@cdc.gov; Palermo, Teri 2; Affiliations: 1: Occupational Health Nurse, Division of Surveillance, Health Hazard Evaluation, Field Studies; 2: Public Health Advisor, Division of Respiratory Disease Studies, Centers of Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Ohio; Issue Info: May2005, Vol. 11 Issue 2, p193; Thesaurus Term: Agricultural industries; Thesaurus Term: Rural development; Thesaurus Term: Industrial safety; Thesaurus Term: Public health; Thesaurus Term: Agriculture; Subject: United States; Author-Supplied Keyword: Community-based; Author-Supplied Keyword: Ergonomics; Author-Supplied Keyword: Farm worker; Author-Supplied Keyword: Farmer; Author-Supplied Keyword: Intervention research; Author-Supplied Keyword: Participatory research; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 925120 Administration of Urban Planning and Community and Rural Development; Number of Pages: 11p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Clark, Susan B.
AU - Turnipseed, Sherri B.
AU - Madson, Mark R.
AU - Hurlbut, Jeffrey A.
AU - Laura R. Kuck
AU - Sofos, John N.
T1 - Confirmation of Sulfamethazine, Sulfathiazole, and Sulfadimethoxine Residues in Condensed Milk and Soft-Cheese Products by Liquid Chromatography/Tandem Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/05//May/Jun2005
VL - 88
IS - 3
M3 - Article
SP - 736
EP - 743
SN - 10603271
AB - Describes a liquid chromatography/tandem mass spectrometry method for the simultaneous detection of three sulfonamide drug residues at 1.25 ppb in condensed milk and soft-cheese products. Steps that comprise the method; Method validation; Confirmation of the presence of sulfathiazole and sulfamethazine residues in three out of six imported flavored and unflavored condensed milk and cream cheese bars.
KW - SULFONAMIDES
KW - LIQUID chromatography
KW - MASS spectrometry
KW - CONDENSED milk
KW - CHEESE products
KW - ANALYTICAL chemistry
N1 - Accession Number: 17279735; Clark, Susan B. 1 Turnipseed, Sherri B. 1; Email Address: sherri.turnipseed@fda.hhs.gov Madson, Mark R. 1 Hurlbut, Jeffrey A. 2 Laura R. Kuck 3 Sofos, John N. 4; Affiliation: 1: U.S. Food and Drug Administration, PO Box 25087, Denver, CO 80225 2: Western Washington University, Chemistry Department. MS-9150, Beilingham, WA 98225 3: University of Colorado, Boulder, CO 80309 4: Colorado State University, Department of Animal Sciences, 1171 Campus Delivery, Ft. Collins, CO 80523; Source Info: May/Jun2005, Vol. 88 Issue 3, p736; Subject Term: SULFONAMIDES; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: CONDENSED milk; Subject Term: CHEESE products; Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 311513 Cheese Manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 36 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Himata, Katsuichi
AU - Warner, Charles
AU - Currie, Douglas
AU - Graves, Qian
AU - Diachenko, Gregory
T1 - The Use of Electrodialysis to Prepare Aqueous Bread Extracts for Bromate Determination by Chemiluminescence.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/05//May/Jun2005
VL - 88
IS - 3
M3 - Article
SP - 794
EP - 799
SN - 10603271
AB - Describes a cleanup procedure based on electrodialysis for the preparation of aqueous bread extracts for bromate determination by chemiluminescence. Procedure's utilization of electrophoresis with three chambers separated by semipermeable membranes; Evaluation of the relative merits of reverse osmosis, ultrafiltration, and nanofiltration membranes with various molecular weight cutoffs; Validation of the method with a variety of commercial bread products.
KW - ELECTRODIALYSIS
KW - BREAD
KW - BROMATE
KW - FOOD -- Analysis
KW - CHEMILUMINESCENCE
KW - ELECTROPHORESIS
N1 - Accession Number: 17279742; Himata, Katsuichi 1 Warner, Charles 2; Email Address: charles.warner@cfsan.fda.gov Currie, Douglas 3 Graves, Qian 4 Diachenko, Gregory 2; Affiliation: 1: Yamazaki Baking Co.. Central Laboratory, 3-15-6 Chitose Sumida, Tokyo, Japan 130-0025 2: U.S. Food and Drug Administration, Office of Food Additive Safety, 5100 Paint Branch Pkwy, College Park, MD 20740 3: University of Maryland, Physics, College Park, MD 20742 4: U.S. Food and Drug Administration, Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: May/Jun2005, Vol. 88 Issue 3, p794; Subject Term: ELECTRODIALYSIS; Subject Term: BREAD; Subject Term: BROMATE; Subject Term: FOOD -- Analysis; Subject Term: CHEMILUMINESCENCE; Subject Term: ELECTROPHORESIS; NAICS/Industry Codes: 311812 Commercial Bakeries; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 311824 Dry Pasta, Dough, and Flour Mixes Manufacturing from Purchased Flour; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, R.G.
AU - Wu, J.Z.
AU - McDowell, T.W.
AU - Welcome, D.E.
AU - Schopper, A.W.
T1 - Distribution of mechanical impedance at the fingers and the palm of the human hand
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2005/05//
VL - 38
IS - 5
M3 - Article
SP - 1165
EP - 1175
SN - 00219290
AB - A comprehensive understanding of the complex biodynamic response of the human fingers–hand–arm system may help researchers determine the causation of injuries arising from hand-transmitted vibration. This study theoretically demonstrates that the mechanical impedance (MI) in a hand power grip, as a measure of the biodynamic response of the system, can be divided into finger MI and palm MI. A methodology is developed to measure them separately and to investigate their distribution characteristics. This study involves 6 adult male subjects, constant-velocity sinusoidal excitations at 10 different discrete frequencies (16, 25, 40, 63, 100, 160, 250, 400, 630, 1000 Hz), and three different hand–handle coupling conditions. Our results suggest that at low frequencies (⩽40 Hz), the palm MI is substantially higher than the finger MI; the majority of the hand MI remains distributed at the palm up to 100 Hz; and at frequencies higher than 160 Hz, the finger MI is comparable to or higher than the palm MI. Furthermore, at frequencies equal to or above 100 Hz, the finger MI is practically independent of the palm–handle coupling conditions. Knowledge of the MI distribution pattern may increase the understanding of vibration transmission to the hand and aid in the development of effective isolation devices. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXTREMITIES (Anatomy)
KW - VIBRATION (Mechanics)
KW - HAND
KW - OSCILLATIONS
KW - Fingers
KW - Hand-arm vibration
KW - Hand-transmitted vibration
KW - Mechanical impedance of the hand
KW - Vibration power absorption
N1 - Accession Number: 16839809; Dong, R.G.; Email Address: rkd6@cdc.gov Wu, J.Z. 1 McDowell, T.W. 1 Welcome, D.E. 1 Schopper, A.W. 1; Affiliation: 1: Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2201, Morgantown, WV 26505, USA; Source Info: May2005, Vol. 38 Issue 5, p1165; Subject Term: EXTREMITIES (Anatomy); Subject Term: VIBRATION (Mechanics); Subject Term: HAND; Subject Term: OSCILLATIONS; Author-Supplied Keyword: Fingers; Author-Supplied Keyword: Hand-arm vibration; Author-Supplied Keyword: Hand-transmitted vibration; Author-Supplied Keyword: Mechanical impedance of the hand; Author-Supplied Keyword: Vibration power absorption; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jbiomech.2004.05.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donald E. Eggerth
T1 - Convergent Validity of O*NET Holland Code Classifications.
JO - Journal of Career Assessment
JF - Journal of Career Assessment
Y1 - 2005/05//
VL - 13
IS - 2
M3 - Article
SP - 150
EP - 168
SN - 10690727
AB - The interpretive ease and intuitive appeal of the Holland RIASEC typology have made it nearly ubiquitous in vocational guidance settings. Its incorporation into the Occupational Information Network (O*NET) has moved it another step closer to reification. This research investigated the rates of agreement between Holland code classifications from three major sources. The Holland code classifications from the O*NET were compared with those from the Strong Interest Inventory and the Dictionary of Holland Occupational Types using six different methods. The mean pairwise rate of agreement for the first Holland code letter was 70.6%, with a three-way rate of agreement of 60.21%. The mean pairwise rate of agreement for the first and second Holland code letters was 32.33%, with a three-way rate of agreement of 15.71%. The mean pairwise rate of agreement for the first, second, and third Holland code letters was 12.56%, with a three-way rate of agreement of 2.62%. The implications of these findings for research and counseling practice are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Career Assessment is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VOCATIONAL guidance
KW - TRUTHFULNESS & falsehood
KW - COUNSELING
KW - APPLIED psychology
N1 - Accession Number: 20132648; Donald E. Eggerth 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, and West Virginia University, eggerth@cdc.gov. West Virginia University. West Virginia University. Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; Source Info: May2005, Vol. 13 Issue 2, p150; Subject Term: VOCATIONAL guidance; Subject Term: TRUTHFULNESS & falsehood; Subject Term: COUNSELING; Subject Term: APPLIED psychology; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Iyengar, Puneeth
AU - Espina, Virginia
AU - Williams, Terence W.
AU - Ying Lin
AU - Berry, David
AU - Jelicks, Linda A.
AU - Hyangkyu Lee
AU - Temple, Karla
AU - Graves, Reed
AU - Pollard, Jeffrey
AU - Chopra, Neeru
AU - Russell, Robert G.
AU - Sasisekharan, Ram
AU - Trock, Bruce J.
AU - Lippman, Marc
AU - Calvert, Vaierie S.
AU - Petricoin III, Emanuel F.
AU - Liotta, Lance
AU - Dadachova, Ekaterina
AU - Pestell, Richard G.
T1 - Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2005/05//
VL - 115
IS - 5
M3 - journal article
SP - 1163
EP - 1176
SN - 00219738
AB - The interactions of transformed cells with the surrounding stromal cells are of importance for tumor progression and metastasis. The relevance of adipocyte-derived factors to breast cancer cell survival and growth is well established. However, it remains unknown which specific adipocyte-derived factors are most critical in this process. Collagen VI is abundantly expressed in adipocytes. Collagen(-/-) mice in the background of the mouse mammary tumor virus/polyoma virus middle T oncogene (MMTV-PyMT) mammary cancer model demonstrate dramatically reduced rates of early hyperplasia and primary tumor growth. Collagen VI promotes its growth-stimulatory and pro-survival effects in part by signaling through the NG2/chondroitin sulfate proteoglycan receptor expressed on the surface of malignant ductal epithelial cells to sequentially activate Akt and beta-catenin and stabilize cyclin D1. Levels of the carboxyterminal domain of collagen VIalpha3, a proteolytic product of the full-length molecule, are dramatically upregulated in murine and human breast cancer lesions. The same fragment exerts potent growth-stimulatory effects on MCF-7 cells in vitro. Therefore, adipocytes play a vital role in defining the ECM environment for normal and tumor-derived ductal epithelial cells and contribute significantly to tumor growth at early stages through secretion and processing of collagen VI. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAT cells
KW - ADIPOSE tissues
KW - CONNECTIVE tissue cells
KW - COLLAGEN
KW - EXTRACELLULAR matrix proteins
KW - TUMORS
N1 - Accession Number: 16924037; Iyengar, Puneeth 1 Espina, Virginia 2 Williams, Terence W. 3 Ying Lin 1 Berry, David 4,5 Jelicks, Linda A. 6 Hyangkyu Lee 3 Temple, Karla 7 Graves, Reed 8 Pollard, Jeffrey 9 Chopra, Neeru 10 Russell, Robert G. 11 Sasisekharan, Ram 12 Trock, Bruce J. 13 Lippman, Marc 14 Calvert, Vaierie S. 15 Petricoin III, Emanuel F. 15 Liotta, Lance 2 Dadachova, Ekaterina 16 Pestell, Richard G. 11; Affiliation: 1: Departments of Cell Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA. 2: Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA. 3: Department of Molecular Pharmacology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA. 4: Harvard Medical School, Boston, Massachusetts, USA. 5: Harvard, Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, USA. 6: Department of Physiology and Biophysics, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA. 7: Committee on Human Nutrition and Nutritional Biology, University of Chicago, Chicago, Illinois, USA. 8: Department of Biochemistry, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA. 9: Department of Developmental and Molecular Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA. 10: Department of Pathology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA. 11: Lombardi Comprehensive Cancer Center, Georgetown University Medical School, Georgetown, Washington, DC, USA. 12: Center for Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. 13: Department of Urology, Johns Hopkins University, Baltimore, Maryland, USA. 14: Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. 15: FDA, National Cancer Institute Clinical Proteomics Program, Office of Cellular and Gene Therapy, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA. 16: Department of Nuclear Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York, USA.; Source Info: May2005, Vol. 115 Issue 5, p1163; Subject Term: FAT cells; Subject Term: ADIPOSE tissues; Subject Term: CONNECTIVE tissue cells; Subject Term: COLLAGEN; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: TUMORS; Number of Pages: 14p; Illustrations: 2 Color Photographs, 5 Graphs; Document Type: journal article
L3 - 10.1172/JCI200523424
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106531841
T1 - Severity of illness, race, and choice of local versus distant hospitals among the elderly.
AU - Basu J
Y1 - 2005/05//
N1 - Accession Number: 106531841. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Instrumentation: Resource Demand Scale (RDSCALE). NLM UID: 9103800.
KW - Age Factors
KW - Race Factors
KW - Severity of Illness -- In Old Age
KW - Travel -- In Old Age
KW - Aged
KW - Ambulatory Care
KW - Connecticut
KW - Cross Sectional Studies
KW - Databases, Health -- Utilization
KW - Female
KW - Hospitalization
KW - Male
KW - Multiple Logistic Regression
KW - New Jersey
KW - New York
KW - Odds Ratio
KW - Patient Admission
KW - Pennsylvania
KW - Referral and Consultation
KW - Scales
KW - Human
SP - 391
EP - 405
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 16
IS - 2
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - This study examines travel patterns for hospitalization among elderly patients to address whether there are differences by age and race/ethnicity, and whether the differences persist even when a severe illness occurs. Using the Healthcare Cost and Utilization Project (HCUP) State Inpatient database (SID) of the Agency for Healthcare Research and Quality, the study focuses on New York residents in the 65-and-over age group who are hospitalized in New York or neighboring states. Two types of hospital admissions are used: referral-sensitive admissions (fairly discretionary, high-technology procedures) and ambulatory care-sensitive admissions (avoidable with appropriate primary care). The study found that, after adjusting for other covariates, travel progressively declines with age among the elderly. Travel patterns across elderly age cohorts were not significantly different when patients were more severely ill. Members of racial/ethnic minority groups were less likely to travel than whites, and this gap persisted even when a severe illness occurred.
SN - 1049-2089
AD - Senior Economist, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Room 6048, Rockville, MD 20850; Jbasu@ahrq.gov
U2 - PMID: 15937400.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106474988
T1 - Breast pump adverse events: reports to the Food and Drug Administration.
AU - Brown SL
AU - Bright RA
AU - Dwyer DE
AU - Foxman B
Y1 - 2005/05//
N1 - Accession Number: 106474988. Language: English. Entry Date: 20050701. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8709498.
KW - Breast Pumps -- Adverse Effects
KW - Databases
KW - Incident Reports
KW - United States Food and Drug Administration
SP - 169
EP - 174
JO - Journal of Human Lactation
JF - Journal of Human Lactation
JA - J HUM LACT
VL - 21
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Breast pumps are medical devices used to express milk and maintain the milk supply. The purpose of this study was to characterize adverse events reported to the United States Food and Drug Administration (FDA) on breast pumps. Thirty-seven adverse event reports on breast pumps were identified from the Manufacturer and User Facility Device Experience database between 1992 and 2003. Four additional reports were found in the Device Experience Network database from 1992 to 1996. The most commonly reported adverse events for electric breast pumps were pain, soreness, or discomfort; the need for medical intervention; and breast tissue damage. Most frequently reported problems for manual breast pumps were breast tissue damage and infection. Contamination of breast milk during pumping was also reported. Breast pump adverse events are likely underreported to the FDA. Reporting adverse events is important for improving the design and manufacture of breast pumps and subsequently decreasing adverse events.
SN - 0890-3344
AD - Medical Device Epidemiologist, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, HFZ-541, Rockville, MD 20850
U2 - PMID: 15886342.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Malaspina, Angela
AU - Moir, Susan
AU - Orsega, Susan M.
AU - Vasquez, Joshua
AU - Miller, Natalie J.
AU - Donoghue, Eileen T.
AU - Kottilil, Shyamasundaran
AU - Gezmu, Misrak
AU - Follmann, Dean
AU - Vodeiko, Galina M.
AU - Levandowski, Roland A.
AU - Mican, JoAnn M.
AU - Fauci, Anthony S.
T1 - Compromised B Cell Responses to Influenza Vaccination in HIV-Infected Individuals.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/05//5/1/2005
VL - 191
IS - 9
M3 - Article
SP - 1442
EP - 1450
SN - 00221899
AB - Background. Yearly influenza vaccination, although recommended for human immunodeficiency virus (HIV)- infected individuals, has not received thorough evaluation in the era of antiretroviral therapy. We assessed the impact of HIV disease on B cell responses to influenza vaccination. Methods. Sixty-four HIV-infected and 17 HIV-negative individuals received the 2003-2004 trivalent inactivated influenza vaccine. Frequencies of influenza-specific antibody-secreting cells (ASCs) were measured by enzyme-linked immunospot (ELISPOT) assay, and antibody responses were measured by hemagglutination-inhibition (HI) assay. Memory responses to influenza were measured by ELIS POT assay after polyclonal activation of B cells in vitro. Results. Prevaccination HI titers were significantly higher in HIV-negative than in HIV-infected individuals. Peak HI titers and influenza-specific ASC frequencies were directly correlated with CD4+ T cell counts in HIV- infected individuals. Influenza-specific memory B cell responses were significantly lower in HIV-infected than in HIV-negative individuals and were directly correlated with CD4+ T cell counts. Conclusions. HIV infection is associated with a weak antibody response to influenza vaccination that is com- pounded by a poor memory B cell response. CD4+ T cell count is a critical determinant of responsiveness to influenza vaccination, and the contribution of plasma HIV RNA level is suggestive and warrants further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - HIV (Viruses)
KW - RESPIRATORY infections
KW - VIRUS diseases
KW - INFLUENZA
KW - VACCINATION
N1 - Accession Number: 16640825; Malaspina, Angela 1 Moir, Susan 1; Email Address: smoir@niaid.nih.gov Orsega, Susan M. 2 Vasquez, Joshua 1 Miller, Natalie J. 1 Donoghue, Eileen T. 1 Kottilil, Shyamasundaran 1 Gezmu, Misrak 3 Follmann, Dean 3 Vodeiko, Galina M. 4 Levandowski, Roland A. 4 Mican, JoAnn M. 3 Fauci, Anthony S. 1; Affiliation: 1: Laboratory of Immunoregulation , National Institute of Allergy and Infectious Diseases 2: Clinical Center, Nursing and Patient Care Services, National Institutes of Health 3: Office of Clinical Research, National Institute of Allergy and Infectious Diseases 4: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: 5/1/2005, Vol. 191 Issue 9, p1442; Subject Term: HIV infections; Subject Term: HIV (Viruses); Subject Term: RESPIRATORY infections; Subject Term: VIRUS diseases; Subject Term: INFLUENZA; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jhaveri, Ravi
AU - Kundu, Pallob
AU - Shapiro, Alan M.
AU - Venkatesan, Arun
AU - Dasgupta, Asim
T1 - Effect of Heptitis C Virus Core Protein on Cellular Gene Expression: Specific Inhibition of Cyclooxygenase 2.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/05//5/1/2005
VL - 191
IS - 9
M3 - Article
SP - 1498
EP - 1506
SN - 00221899
AB - Hepatitis C virus (HCV) core protein plays a significant role in the alteration of cellular gene expression. We expressed HCV core protein using a tetracycline-inducible expression system in HeLa cell lines. Profiles of gene expression in cells expressing the HCV core protein were compared with those in control cells by use of microarray analysis. Cells expressing the HCV core protein showed 86 down-regulated and 41 up-regulated genes, compared with control cells. One gene affected was cyclooxygenase 2 (COX-2). Levels of both COX-2 RNA and the Cox-2 protein were significantly inhibited after the expression of HCV core protein in HeLa cells. Similar results were obtained in hepatoma cells and in a functional assay that measured the production of the Cox-2 protein in response to a mitogenic stimulus. The inhibition of the Cox-2 protein could serve as a means of muting the cellular inflammatory response during HCV infection. Correlation of these findings with analysis of clinical specimens from chronically infected patients should lend further significance to the down-regulation of the inflammatory response via Cox-2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC regulation
KW - GENE expression
KW - HEPATITIS C
KW - CANCER cells
KW - VIRAL hepatitis
KW - HEPATITIS C virus
N1 - Accession Number: 16640683; Jhaveri, Ravi 1 Kundu, Pallob 2 Shapiro, Alan M. 3 Venkatesan, Arun 4 Dasgupta, Asim 2; Email Address: dasgupta@ucla.edu; Affiliation: 1: Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina 2: Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles 3: Division of Pediatric Drug Development, Office of Counter-Terrorism, and Pediatric Drug Development Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 4: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland; Source Info: 5/1/2005, Vol. 191 Issue 9, p1498; Subject Term: GENETIC regulation; Subject Term: GENE expression; Subject Term: HEPATITIS C; Subject Term: CANCER cells; Subject Term: VIRAL hepatitis; Subject Term: HEPATITIS C virus; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sealey, Wendy M.
AU - Stratton, Shawna L.
AU - Mock, Donald M.
AU - Hansen, Deborah K.
T1 - Marginal Maternal Biotin Deficiency in CD-I Mice Reduces Fetal Mass of Biotin-dependent Carboxylases.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2005/05//
VL - 135
IS - 5
M3 - Article
SP - 973
EP - 977
SN - 00223166
AB - Marginal maternal biotin deficiency reduces hepatic activity of biotin-dependent carboxylases and causes high rates of fetal birth defects in mice. We tested the hypothesis that the decreased carboxylase activity observed in deficient dams and their offspring is mediated by decreased abundance of biotinylated carboxylases, decreased expression of their mRNAs, or both. During gestation, CD-1 mice were fed a diet that induced biotin deficiency or a biotin-sufficient diet. On gestational d 17, gravid uteri were removed, and each live fetus was examined grossly for defects. The expected high incidence of cleft palate (83%) in offspring was observed. In maternal and fetal liver, acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-C0A carboxylase, and β-methylcrotonyl-CoA carboxylase abundances were determined by Western blotting; the content of mRNAs for most of these enzymes and holocarboxylase synthetase was determined by real-time RT-PCR. Biotin deficiency significantly reduced the abundance of the carboxylases in maternal and fetal liver; neither the content of mRNAs for the carboxylases nor holocarboxylase synthetase changed. This study provides evidence that the decrease in carboxylase activities is attributable to a decrease in the abundance of biotinylated carboxylases; further, this effect is more severe in fetuses than dams. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN abnormalities
KW - BIOTIN
KW - VITAMIN B complex
KW - VITAMIN B deficiency
KW - WESTERN immunoblotting
KW - PREGNANCY
KW - biotin
KW - biotin-dependent carboxylases
KW - CD-1 mice
KW - mRNA
N1 - Accession Number: 17065142; Sealey, Wendy M. 1,2 Stratton, Shawna L. 1 Mock, Donald M. 1,3; Email Address: mockdonaldm@uams.edu Hansen, Deborah K. 4; Affiliation: 1: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 2: Hagerman Fish Culture Experiment Station, University of Idaho, Hagerman, ID 83332 3: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 4: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079; Source Info: May2005, Vol. 135 Issue 5, p973; Subject Term: HUMAN abnormalities; Subject Term: BIOTIN; Subject Term: VITAMIN B complex; Subject Term: VITAMIN B deficiency; Subject Term: WESTERN immunoblotting; Subject Term: PREGNANCY; Author-Supplied Keyword: biotin; Author-Supplied Keyword: biotin-dependent carboxylases; Author-Supplied Keyword: CD-1 mice; Author-Supplied Keyword: mRNA; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106648369
T1 - A survey of private sector respirator use in the United States: an overview of findings.
AU - Doney BC
AU - Groce DW
AU - Campbell DL
AU - Greskevitch MF
AU - Hoffman WA
AU - Middendorf PJ
AU - Syamlal G
AU - Bang KM
Y1 - 2005/05//
N1 - Accession Number: 106648369. Language: English. Entry Date: 20050617. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D38-9. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Utilization
KW - Education, Continuing (Credit)
KW - Questionnaires
KW - United States
KW - Human
SP - 267
EP - 276
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Limitations of previous surveys of respirator use led the National Institute for Occupational Safety and Health (NIOSH) and the Bureau of Labor Statistics to undertake a survey of respirator use and practices among U.S. private sector employers. The survey was mailed to 40,002 private sector establishments in August 2001; the responses were used to develop national estimates. Respirator use was required in 4.5% of establishments and for 3.1% of employees. Of the establishments requiring respirator use, 95% used air-purifying respirators and 17% used air-supplied respirators. Manufacturing; mining (including oil and gas extraction); construction; and agriculture, forestry, and fishing had the highest rates of establishment respirator use. Respirators were used most frequently to protect against dust/mist, paint vapors, and solvents. Large percentages of establishments requiring respirator use had indicators of potentially inadequate respirator programs. Of establishments requiring respirator use, 91% had at least one indicator of a potentially inadequate respiratory protection program, while 54% had at least five indicators. The survey findings suggest that large numbers of employers may not follow NIOSH recommendations and Occupational Safety and Health Administration (OSHA) and Mine Safety and Health Administration (MSHA) requirements for the selection and use of respirators, potentially putting workers at risk. The findings will aid efforts to increase the appropriate use of respirators in the workplace.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road Mailstop G900.2, Morgantown, WV 26505; bdoney@cdc.gov
U2 - PMID: 15814381.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106648369&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, D. L.
AU - Cunningham, W. C.
T1 - Analysis of total diet study foods for gamma-ray emitting radionuclides.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2005/05//
VL - 264
IS - 2
M3 - Article
SP - 371
EP - 376
SN - 02365731
AB - Foods collected for radionuclide analysis under the Food and Drug Administration's (FDA's) Total Diet Study (TDS) Program were analyzed by the Center for Food Safety and Applied Nutrition (CFSAN) as quality assurance (QA) for analyses performed at FDA's Winchester Engineering and Analytical Center (WEAC). 200-ml QA portions were analyzed for gamma-ray emitting fission products and naturally occurring radionuclides. Efficiency, pileup correction, absorption effects, and accuracy were determined by analyzing a variety of certified reference materials and KNO3 and KCl solutions.40 K results agreed well with those from WEAC and with total K results from other techniques. Count times as low as 2 minutes were sufficient to confirm that radioactivity concentrations were below regulatory limits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOISOTOPES
KW - GAMMA rays
KW - FOOD
KW - NUTRITION
KW - QUALITY assurance
KW - FOOD handling
N1 - Accession Number: 16777666; Anderson, D. L. 1; Email Address: david.anderson@cfsan.fda.gov Cunningham, W. C. 1; Affiliation: 1: Elemental Research Branch (HFS-338), U. S. Food and Drug Administration, USA.; Source Info: May2005, Vol. 264 Issue 2, p371; Subject Term: RADIOISOTOPES; Subject Term: GAMMA rays; Subject Term: FOOD; Subject Term: NUTRITION; Subject Term: QUALITY assurance; Subject Term: FOOD handling; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1007/s10967-005-0723-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16777666&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Matthew R.
T1 - Effect of pulse characteristics on temperature rise due to ultrasound absorption at a bone/soft-tissue interface.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2005/05//
VL - 117
IS - 5
M3 - Article
SP - 3281
EP - 3287
SN - 00014966
AB - The transient temperature rise at a bone/soft-tissue interface is an important quantity in the safety evaluation of procedures involving trains of high-intensity ultrasound pulses. Mathematical models based upon the time-averaged intensity of the pulse train can provide rapid estimates of the temperature rise, but are known to underestimate the temperature rise during the on-time of the pulse. This paper extends a previous analytical model to account for pulse shape, and provides error estimates for simulations employing time-averaged intensities. A simple analytic expression for the interface temperature that accounts for both bone and soft-tissue properties is provided. The analytic expression agrees well with temperature rise predictions based upon the finite-element method, when the insonation time is large compared to the pulse repetition period. In this case of large relative insonation time, the pulse shape is found to be inconsequential. © 2005 Acoustical Society of America. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEMPERATURE
KW - PULSE frequency modulation
KW - IMAGING systems in medicine
KW - FINITE element method
KW - BONE
N1 - Accession Number: 20264614; Myers, Matthew R. 1; Email Address: matthew.myers@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, HFZ-170, U.S. Food and Drug Administration, Rockville, Maryland 20852; Source Info: May2005, Vol. 117 Issue 5, p3281; Subject Term: TEMPERATURE; Subject Term: PULSE frequency modulation; Subject Term: IMAGING systems in medicine; Subject Term: FINITE element method; Subject Term: BONE; Number of Pages: 7p; Illustrations: 3 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1121/1.1879232
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20264614&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
AU - Laib, Andres
AU - Stuber, Angela P.
AU - Reynolds, James C.
T1 - Comparison of measurements of phase velocity in human calcaneus to Biot theory.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2005/05//
VL - 117
IS - 5
M3 - Article
SP - 3319
EP - 3324
SN - 00014966
AB - Biot’s theory for elastic propagation in porous media has previously been shown to be useful for modeling the dependence of phase velocity on porosity in bovine cancellous bone in vitro. In the present study, Biot’s theory is applied to measurements of porosity-dependent phase velocity in 53 human calcanea in vitro. Porosity was measured using microcomputed tomography for some samples (n=23) and estimated based on bone mineral densitometry for the remaining samples (n=30). The phase velocity at 500 kHz was measured in a water tank using a through-transmission technique. Biot’s theory performed well for the prediction of the dependence of sound speed on porosity. The trend was quasilinear, but both the theory and experiment show similar slight curvature. The root mean square error (RMSE) of predicted versus measured sound speed was 15.8 m/s. © 2005 Acoustical Society of America. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POROUS materials
KW - POROSITY
KW - SPEED of sound
KW - SPEED
KW - HEEL bone
KW - BONE densitometry
N1 - Accession Number: 20264610; Wear, Keith A. 1; Email Address: Kaw@cdrh.fda.gov Laib, Andres 2 Stuber, Angela P. 2,3 Reynolds, James C. 2,3; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-140, 12720 Twinbrook Parkway, Rockville, Maryland 20852 2: SCANCO Medical AG, Auenring 6-8, CH-8303 Bassersdorf, Switzerland 3: National Institutes of Health Clinical Center, Bethesda, Maryland 20892; Source Info: May2005, Vol. 117 Issue 5, p3319; Subject Term: POROUS materials; Subject Term: POROSITY; Subject Term: SPEED of sound; Subject Term: SPEED; Subject Term: HEEL bone; Subject Term: BONE densitometry; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1121/1.1886388
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walker, Deborah S.
AU - Darling Fisher, Cynthia S.
AU - Sherman, Anita
AU - Wybrecht, Barbara
AU - Kyndely, Kathleen
T1 - Fetal alcohol spectrum disorders prevention: An exploratory study of women's use of, attitudes toward, and knowledge about alcohol.
JO - Journal of the American Academy of Nurse Practitioners
JF - Journal of the American Academy of Nurse Practitioners
Y1 - 2005/05//
VL - 17
IS - 5
M3 - Article
SP - 187
EP - 193
PB - Wiley-Blackwell
SN - 10412972
AB - The incidence of fetal alcohol spectrum disorders (FASD) is increasing, even though it is 100% preventable. This study examined use of, knowledge about, and attitudes toward alcohol of women requesting emergency contraception (EC) and/or a pregnancy test, and evaluated whether a brief intervention would be effective in educating them about the risks of FASD. Fifty women from two outpatient clinics participated. Information was collected on demographic and personal health habits, alcohol use, and knowledge of and attitudes toward alcohol. As a brief intervention to increase knowledge about FASD, participants read a short pamphlet about the risks of alcohol exposure in pregnancy and then completed a post-test questionnaire. Descriptive statistics, including means, standard deviations, and skewness, were calculated for all variables. Pearson correlations were computed to assess relationships between demographic/lifestyle variables and attitudes toward and knowledge about alcohol. Paired t-tests were used to analyze the relationship between pretest and post-test knowledge scores. The majority of participants were single (76%), college educated (94%), and received EC at the clinic visit (60%). The average age was 24 years. Slightly over half (52%) reported drinking beer at least once a week, with one to six cans on occasion. Younger women expressed more tolerant attitudes toward alcohol use ( p= .02) and drank significantly more beer on occasion ( p= .015). Women who reported drinking alcohol when they last had sex were significantly ( p= .017) less tolerant in their attitudes toward alcohol use. The intervention used in this study was effective in communicating knowledge about FASD to this population ( p < .0001). These findings suggest that young women may be engaging in behaviors that could put potential offspring at risk for exposure to alcohol. Clinicians are advised to take a thorough history to determine alcohol use in all women of childbearing age and to provide information regarding FASD prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Academy of Nurse Practitioners is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN alcoholics
KW - DRINKING of alcoholic beverages
KW - ALCOHOLISM
KW - OBSTETRICS
KW - DRINKING behavior
KW - MEDICAL care -- Research
KW - Adolescence
KW - emergency contraception
KW - fetal alcohol spectrum disorders
KW - preconceptional care
KW - preconceptional care.
N1 - Accession Number: 17753648; Walker, Deborah S. 1; Email Address: dswalker@wayne.edu Darling Fisher, Cynthia S. 2 Sherman, Anita 3 Wybrecht, Barbara 4,5 Kyndely, Kathleen 6; Affiliation: 1: Associate Professor, College of Nursing, School of Medicine, Wayne State University, Detroit, MI 48202. 2: Assistant Professor, School of Nursing, University of Michigan, Ann Arbor. 3: Medical Services Manager, Planned Parenthood, Ann Arbor, MI. 4: FASD Clinical Nurse Specialist, Spectrum Health FASD Diagnostic Clinic, Grand Rapids, MI. 5: Field Trainer for Substance Abuse and Mental Health Services Administration, FASD Center for Excellence. 6: Lecturer, School of Nursing, University of Michigan, Ann Arbor.; Source Info: May2005, Vol. 17 Issue 5, p187; Subject Term: WOMEN alcoholics; Subject Term: DRINKING of alcoholic beverages; Subject Term: ALCOHOLISM; Subject Term: OBSTETRICS; Subject Term: DRINKING behavior; Subject Term: MEDICAL care -- Research; Author-Supplied Keyword: Adolescence; Author-Supplied Keyword: emergency contraception; Author-Supplied Keyword: fetal alcohol spectrum disorders; Author-Supplied Keyword: preconceptional care; Author-Supplied Keyword: preconceptional care.; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 7p; Document Type: Article
L3 - 10.111/j.1745-7599.2005.0031.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17753648&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106516481
T1 - Product news.
AU - Morgan D
Y1 - 2005/05//2005 May
N1 - Accession Number: 106516481. Language: English. Entry Date: 20050923. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9306822.
KW - Bandages and Dressings -- Economics
KW - Bandages and Dressings -- Trends
KW - Wound Care -- Economics
KW - Insurance, Health, Reimbursement
KW - United Kingdom
SP - 31
EP - 34
JO - Journal of Tissue Viability
JF - Journal of Tissue Viability
JA - J TISSUE VIABILITY
VL - 15
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 0965-206X
AD - Consultant in Pharmaceutical Public Health, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold, Flintshire CH7 1PZ; david.morgan@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Momosaki, S.
AU - Nakashima, Y.
AU - Kojiro, M.
AU - Tabor, E.
T1 - HBsAg-negative hepatitis B virus infections in hepatitis C virus-associated hepatocellular carcinoma.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005/05//
VL - 12
IS - 3
M3 - Article
SP - 325
EP - 329
PB - Wiley-Blackwell
SN - 13520504
AB - This study was conducted to evaluate reports that hepatitis B virus (HBV) DNA sequences can be found in the serum and/or tumour tissue from some hepatocellular carcinoma (HCC) patients who have no detectable hepatitis B surface antigen (HBsAg) in their sera. Such HBV infections would be highly atypical, because prospective studies have shown a clear succession of specific serologic markers during and after most HBV infections. As most HBsAg-negative HCC patients in Japan have hepatitis C virus (HCV) infections, the present study was conducted to determine whether some of these patients actually have unrecognized HBV infections. Thirty newly diagnosed HCC patients from Kurume, Japan, with antibody to the hepatitis C virus (anti-HCV) were studied. None of the 30 had HBsAg detectable in their serum. Of 22 for whom test results for antibodies to the hepatitis B core antigen (anti-HBc) and antibodies to HBsAg (anti-HBs) were available, 14 (64%) had anti-HBc and anti-HBs, four (18%) had anti-HBc alone, and four (18%) had no HBV markers. Nested polymerase chain reaction was used to detect the HBV surface (S), core (C), polymerase (P) and core promoter gene sequences in the HCC tissues and in the adjacent nontumorous liver tissues. HBV DNA was detected in HCC and/or adjacent nontumorous liver in 22 of 30 (73%) patients [detected in both HCC and nontumorous liver in 19/30 patients (63%)]. Among the 22 patients with detectable HBV DNA, more than one HBV gene was detected in 10 (46%). Among the four patients whose sera were negative for all HBV markers, three had HBV DNA in either HCC and nontumorous liver (two cases) or only in the nontumorous liver (one case); HBV DNA could not be detected in tissues from the fourth patient. In 18 of 21 (86%) patients with detectable HBV core promoter sequences, mutations at both nucleotides 1762 (A–GT) and 1764 (G–A) in the core promoter region were found. No deletions were detected in the core promoter gene region of the type reported to be associated with some cases of HBsAg-negative HBV infection. Thus, HBV DNA was detectable in 22 (73%) HBsAg-negative, anti-HCV-positive HCCs, including three (10%) who were also negative for anti-HBc and anti-HBs. HBV mutations at both nucleotides 1762 (A–GT) and 1764 (G–A) in the core promoter region were found in the majority of cases, mutations that have previously been reported in HBV that is integrated in HCC DNA. In serologic surveys to determine etiologic associations of HCC, patients such as those in this study would have been incorrectly designated as having‘HCV-associated HCC,’ whereas the data in this study suggest that HBV could have played a role in the development of their HCCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B virus
KW - LIVER -- Cancer
KW - HEPATITIS C virus
KW - HEPATITIS viruses
KW - ONCOLOGY
KW - VIROLOGY
KW - hepatitis B surface antigen
KW - hepatitis B virus
KW - hepatitis C virus
KW - hepatocellular carcinoma
N1 - Accession Number: 16792987; Momosaki, S. 1 Nakashima, Y. 2 Kojiro, M. 2 Tabor, E. 1; Email Address: tabor@cber.fda.gov; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, MD, USA 2: Department of Pathology, Kurume University, Kurume, Japan; Source Info: May2005, Vol. 12 Issue 3, p325; Subject Term: HEPATITIS B virus; Subject Term: LIVER -- Cancer; Subject Term: HEPATITIS C virus; Subject Term: HEPATITIS viruses; Subject Term: ONCOLOGY; Subject Term: VIROLOGY; Author-Supplied Keyword: hepatitis B surface antigen; Author-Supplied Keyword: hepatitis B virus; Author-Supplied Keyword: hepatitis C virus; Author-Supplied Keyword: hepatocellular carcinoma; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1365-2893.2005.00586.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16792987&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Archer, Jeffrey C.
AU - Mabry-Smith, Ronald
AU - Shojaee, Sina
AU - Threet, Jimmy
AU - Eckert, John J.
AU - Litman, Vincent E.
T1 - Dioxin and Furan Levels Found in Tampons.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2005/05//
VL - 14
IS - 4
M3 - Article
SP - 311
EP - 315
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - Background: Human exposure to dioxins and furans through diet and other sources has been of concern for many years. One specific concern, related to exposure in women's health, is the possible link to endometriosis. Although there are differences in opinion about this link, the concern from the public is real. Congressional interest has prompted investigations to determine the amounts of dioxins and furans present in feminine hygiene products available within the United States. Methods: Tampon samples were analyzed via Gas Chromatography/High Resolution Mass Spectrometry (GC/HRMS) using a Micromass AutoSpec Ultima high resolution mass spectrometer at 10,000 mass resolution. As data were confirmed and quantified using direct isotope dilution, only the 17 2,3,7,8-chlorine-containing dioxin and furan concentrations were calculated from these analyses. Results: A total toxic equivalence (TEQ), using the World Health Organization's toxic equivalency factor (TEF) values, was calculated for each sample. The calculated TEQs for samples were not statistically different from those of the calculated TEQs using the average limit of detection (LOD) values. Conclusions: Data show results similar to those reported by DeVito and Schecter (Environ Health Perspect 2002;110:23) in that most of the dioxins and furans were below the detection limit or estimated detection limits (EDLs). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAMPONS
KW - MEDICAL supplies
KW - MENSTRUATION
KW - WOMEN -- Health
KW - DIOXINS
KW - FURANS
N1 - Accession Number: 17137106; Archer, Jeffrey C. 1 Mabry-Smith, Ronald 2 Shojaee, Sina 1 Threet, Jimmy 1 Eckert, John J. 3 Litman, Vincent E. 1; Email Address: VLitman@ora.fda.gov; Affiliation: 1: Food and Drug Administration, Arkansas Regional Laboratory, Jefferson, Arkansas. 2: Food and Drug Administration, Pacific Regional Laboratory, NW, Bothell, Washington. 3: Office of the Secretary, Immediate Office of the Assistant Secretary for Health, Washington, DC.; Source Info: May2005, Vol. 14 Issue 4, p311; Subject Term: TAMPONS; Subject Term: MEDICAL supplies; Subject Term: MENSTRUATION; Subject Term: WOMEN -- Health; Subject Term: DIOXINS; Subject Term: FURANS; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 322121 Paper (except Newsprint) Mills; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1089/jwh.2005.14.311
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17137106&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106514657
T1 - Dioxin and furan levels found in tampons.
AU - Archer JC
AU - Mabry-Smith R
AU - Shojaee S
AU - Threet J
AU - Eckert JJ
AU - Litman VE
Y1 - 2005/05//
N1 - Accession Number: 106514657. Language: English. Entry Date: 20050916. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Office of Women's Health. NLM UID: 101159262.
KW - Dioxins -- Adverse Effects
KW - Heterocyclic Compounds -- Adverse Effects
KW - Tampons -- Adverse Effects
KW - Analytic Research
KW - Chromatography, Gas
KW - Female
KW - Null Hypothesis
KW - Mass Spectrometry
KW - Statistical Significance
KW - Women's Health
KW - Funding Source
KW - Human
SP - 311
EP - 315
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
JA - J WOMENS HEALTH (15409996)
VL - 14
IS - 4
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - BACKGROUND: Human exposure to dioxins and furans through diet and other sources has been of concern for many years. One specific concern, related to exposure in women's health, is the possible link to endometriosis. Although there are differences in opinion about this link, the concern from the public is real. Congressional interest has prompted investigations to determine the amounts of dioxins and furans present in feminine hygiene products available within the United States. METHODS: Tampon samples were analyzed via Gas Chromatography/High Resolution Mass Spectrometry (GC/HRMS) using a Micromass AutoSpec Ultima high resolution mass spectrometer at 10,000 mass resolution. As data were confirmed and quantified using direct isotope dilution, only the 17 2,3,7,8-chlorine-containing dioxin and furan concentrations were calculated from these analyses. RESULTS: A total toxic equivalence (TEQ), using the World Health Organization's toxic equivalency factor (TEF) values, was calculated for each sample. The calculated TEQs for samples were not statistically different from those of the calculated TEQs using the average limit of detection (LOD) values. CONCLUSIONS: Data show results similar to those reported by DeVito and Schecter (Environ Health Perspect 2002;110:23) in that most of the dioxins and furans were below the detection limit or estimated detection limits (EDLs).
SN - 1540-9996
AD - Food and Drug Administration, Arkansas Regional Laboratory, Jefferson, Arkansas
U2 - PMID: 15916504.
DO - 10.1089/jwh.2005.14.311
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Balachandran, Premalatha
AU - Feng Wei
AU - Rui-Chao Lin
AU - Khan, Ikhlas A.
AU - Pasco, David S.
T1 - Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells.
JO - Kidney International
JF - Kidney International
Y1 - 2005/05//
VL - 67
IS - 5
M3 - Article
SP - 1797
EP - 1805
SN - 00852538
AB - Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells. Background. Aristolochia species are nephrotoxic and carcinogenic. Recent studies showed that aristolochic acid (AA) could induce acute renal failure and tubular lesions in several species and available evidences demonstrate the unequivocal role of AA in so called Chinese herbs nephropathy. Methods. A series of AA derivatives isolated from Aristolochia spp. were analyzed for their nephrotoxic potential using the neutral red dye exclusion assay in cultures of LLC-PK1 cells. The structural relationships between AA I and its analogues were compared with their cytotoxic effects to predict structural determinants for AA toxicity. Further, caspase-3 assay was performed on toxic compounds to determine if caspases, the enzymes that play a critical role in apoptosis are involved in AA-induced cytotoxicity. Results. AA I was found to be most toxic followed by AA II, AA VIIIa, and AA Ia in decreasing levels of toxicity. The other compounds, nitrophenanthrene carboxylic acid analogues of AA I, aristolactams, and other derivatives did not exhibit considerable toxicity. The results showed significant relationships between cytotoxicity of AA compounds and the localization of functional groups in their structure. Analogues containing hydroxyl groups diminished cytotoxicity. The demethylated analogues of AA I are markedly less active. The negative impact on cytotoxicity was found on nitroreduction of AA I. AA induced caspase activation was also observed. Conclusion. These cytotoxic data suggest that the nitro and methoxy groups are critical determinants of nephrotoxicologic potency of AA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIAL cells
KW - ARISTOLOCHIACEAE
KW - HERBS
KW - KIDNEY diseases
KW - NEPHROLOGY
KW - INTERNAL medicine
KW - aristolochic acid
KW - structure
KW - toxicity
N1 - Accession Number: 16674160; Balachandran, Premalatha 1 Feng Wei 1 Rui-Chao Lin 1 Khan, Ikhlas A. 1 Pasco, David S. 1; Email Address: dpasco@olemiss.edu; Affiliation: 1: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Oxford, Mississippi; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, Mississippi; and National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing, People's Republic of China; Source Info: May2005, Vol. 67 Issue 5, p1797; Subject Term: EPITHELIAL cells; Subject Term: ARISTOLOCHIACEAE; Subject Term: HERBS; Subject Term: KIDNEY diseases; Subject Term: NEPHROLOGY; Subject Term: INTERNAL medicine; Author-Supplied Keyword: aristolochic acid; Author-Supplied Keyword: structure; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1523-1755.2005.00277.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huizhong Chen
AU - Hopper, Sherryll L.
AU - Cerniglia, Carl E.
T1 - Biochemical and molecular characterization of an azoreductase from Staphylococcus aureus, a tetrameric NADPH-dependent flavoprotein.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2005/05//
VL - 151
IS - 5
M3 - Article
SP - 1433
EP - 1441
SN - 13500872
AB - Azo dyes are a predominant class of colourants used in tattooing, cosmetics, foods and consumer products. A gene encoding NADPH-flavin azoreductase (Azo1) from the skin bacterium Staphylococcus aureus ATCC 25923 was identified and overexpressed in Escherichia coli. RT-PCR results demonstrated that the azo1 gene was constitutively expressed at the mRNA level in S. aureus. Azo1 was found to be a tetramer with a native molecular mass of 85 kDa containing four non-covalently bound FMN. Azo1 requires NADPH, but not NADH, as an electron donor for its activity. The enzyme was resolved to dimeric apoprotein by removing the flavin prosthetic groups using hydrophobic-interaction chromatography. The dimeric apoprotein was reconstituted on-column and in free stage with FMN, resulting in the formation of a fully functional native-like tetrameric enzyme. The enzyme cleaved the model azo dye 2-[4-(dimethylamino)phenylazo]benzoic acid (Methyl Red) into N,N-dimethyl-p-phenylenediamine and 2-aminobenzoic acid. The apparent Km values for NADPH and Methyl Red substrates were 0.074 and 0.057 mM, respectively. The apparent Vmax was 0.4 μM min-1 (mg protein)-1, Azo1 was also able to metabolize Orange II, Amaranth, Ponceau BS and Ponceau S azo dyes. Azo1 represents the first azoreductase to be identified and characterized from human skin microflora. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbiology (13500872) is the property of Society for General Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Staphylococcus aureus
KW - Flavoproteins
KW - Azo dyes
KW - Messenger RNA
KW - Polymerase chain reaction
KW - Flavins
KW - Aminobenzoic acids
N1 - Accession Number: 17177803; Huizhong Chen 1; Email Address: hchen@nctr.fda.gov; Hopper, Sherryll L. 1; Cerniglia, Carl E. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, USA; Issue Info: May2005, Vol. 151 Issue 5, p1433; Thesaurus Term: Escherichia coli; Subject Term: Staphylococcus aureus; Subject Term: Flavoproteins; Subject Term: Azo dyes; Subject Term: Messenger RNA; Subject Term: Polymerase chain reaction; Subject Term: Flavins; Subject Term: Aminobenzoic acids; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 9p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1099/mic.0.27805-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Williams, Robert C.
T1 - ADVANCING Health and Safety.
JO - Military Engineer
JF - Military Engineer
J1 - Military Engineer
PY - 2005/05//May/Jun2005
Y1 - 2005/05//May/Jun2005
VL - 97
IS - 635
M3 - Article
SP - 64
EP - 66
SN - 00263982
AB - Focuses on the accomplishments of the U.S. Public Health Service architects and engineers. Transformation of the Commissioned Corps; Response to natural disasters; Excellence in public health engineering; Advancement of public health science.
KW - UNITED States. Public Health Service
KW - MILITARY engineers
KW - PUBLIC health
KW - HUMAN services
KW - UNITED States
N1 - Accession Number: 17890692; Source Information: May/Jun2005, Vol. 97 Issue 635, p64; Subject Term: UNITED States. Public Health Service; Subject Term: MILITARY engineers; Subject Term: PUBLIC health; Subject Term: HUMAN services; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 3p; ; Illustrations: 3 Color Photographs, 1 Chart; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Swann, John
T1 - My Seven.
JO - National Geographic
JF - National Geographic
Y1 - 2005/05//
VL - 207
IS - 5
M3 - Article
SP - 2
EP - 2
SN - 00279358
AB - Presents a list of seven medicines that changed the world, compiled by John Swann of the United States Food & Drug Administration. Review of the history and use of each medicine; Opium; Smallpox vaccine; Salvarsan; Insulin; Penicillin; Enovid; Thalidomide.
KW - MEDICAL history
KW - OPIUM
KW - SMALLPOX vaccine
KW - SALVARSAN
KW - INSULIN
KW - PENICILLIN
KW - THALIDOMIDE
KW - UNITED States. Food & Drug Administration
KW - SWANN, John
N1 - Accession Number: 16758428; Swann, John 1; Affiliation: 1: Historian, U.S. Food and Drug Administration; Source Info: May2005, Vol. 207 Issue 5, Preceding p2; Subject Term: MEDICAL history; Subject Term: OPIUM; Subject Term: SMALLPOX vaccine; Subject Term: SALVARSAN; Subject Term: INSULIN; Subject Term: PENICILLIN; Subject Term: THALIDOMIDE; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; People: SWANN, John; Number of Pages: 1p; Illustrations: 2 Color Photographs; Document Type: Article; Full Text Word Count: 351
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harding, Richard
AU - Easterbrook, Philippa
AU - Higginson, Irene J.
AU - Karus, Dan
AU - Raveis, Victoria H.
AU - Marconi, Katherine
T1 - Access and equity in HIV/AIDS palliative care: a review of the evidence and responses.
JO - Palliative Medicine
JF - Palliative Medicine
Y1 - 2005/05//
VL - 19
IS - 3
M3 - Article
SP - 251
EP - 258
SN - 02692163
AB - The high prevalence of pain and other symptoms throughout the HIV disease trajectory, the need for management of side effects related to antiretroviral therapy, the continuing incidence of cancers and new emerging co-morbidities as a result of extended life expectancy under new therapeutic regimes, and the ongoing need for terminal care all prove the curative versus palliative dichotomy to be inappropriate. Although there is evidence for both need and effectiveness of palliative care in HIV patient care, access is often poor and care less than optimal. This review aimed to identify evidence of barriers and inequalities in HIV palliative care in order to inform policy and service development. Biomedical databases were searched using a specific strategy, and evidence extracted into the barrier and inequity categories of patient, clinician, service and disease factors. A model of the barriers and inequalities is presented from the evidence. Recommendations are made from the evidence for promoting access and outcomes through integrated palliative care from diagnosis to end-oflife, alongside antiretroviral therapy when initiated. Service responses that have attempted to increase access to palliative care are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Palliative Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - AIDS (Disease)
KW - HOSPICE care
KW - PALLIATIVE treatment
KW - MEDICAL care
KW - PUBLIC health
KW - ACCESS
KW - HIV
KW - HOSPICE
KW - PAIN
KW - PALLIATIVE
KW - REVIEW
N1 - Accession Number: 16745859; Harding, Richard 1; Email Address: richard.harding@kcl.ac.uk Easterbrook, Philippa 2 Higginson, Irene J. 1 Karus, Dan 3 Raveis, Victoria H. 3 Marconi, Katherine 4; Affiliation: 1: Department of Palliative Care and Policy, GKT Medical School, King's College London 2: Department of HIV/GU Medicine, GKT Medical School, King's College London 3: Centre for Study of Psychosocial Health and Illness, Mailman School of Public Health, Columbia University 4: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, US Department of Health and Human Services; Source Info: May2005, Vol. 19 Issue 3, p251; Subject Term: HIV infections; Subject Term: AIDS (Disease); Subject Term: HOSPICE care; Subject Term: PALLIATIVE treatment; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Author-Supplied Keyword: ACCESS; Author-Supplied Keyword: HIV; Author-Supplied Keyword: HOSPICE; Author-Supplied Keyword: PAIN; Author-Supplied Keyword: PALLIATIVE; Author-Supplied Keyword: REVIEW; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
L3 - 10.1191/0269216305pm1005oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Honberg, Lynda
AU - McPherson, Merle
AU - Strickland, Bonnie
AU - Gage, Julia C.
AU - Newacheck, Paul W.
T1 - Assuring Adequate Health Insurance: Results of the National Survey of Children With Special Health Care Needs.
JO - Pediatrics
JF - Pediatrics
Y1 - 2005/05//
VL - 115
IS - 5
M3 - Article
SP - 1233
EP - 1239
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. The purpose of this article is to report the findings of the 2001 National Survey of Children With Special Health Care Needs regarding the extent to which children with special health care needs (CSHCN) have access to public or private health insurance that meets their needs. Methodology. As part of its effort to develop systems of care for CSHCN, the US Maternal and Child Health Bureau established a health insurance core outcome. Successful attainment was measured on the basis of whether the child met 3 distinct components at the time of the interview: presence of public or private coverage; continuity of coverage over the previous 12 months; and adequacy of coverage. Adequacy of coverage was measured from the family's perspective of whether their insurance covered needed services, covered a reasonable share of costs, and allowed families to see the providers they felt were best for their child. Bivariate and multivariate statistical methods were used to assess independent predictors of respondents meeting the health insurance core outcome. Results. Results of the survey indicated that 59.6% of CSHCN nationally met the health insurance core outcome using the 3 components of presence of insurance coverage, continuity of coverage, and adequacy of coverage. Poverty status, race/ethnicity, and functional ability were significant factors in whether a child met the health insurance core outcome as well as each of the 3 components. Of Hispanic and non-Hispanic black CSHCN, 45.2% and 57.6%, respectively, met the health insurance core outcome, compared with 62.5% of their white counterparts. Children with the most limited functional ability were 50% less likely to meet the health insurance core outcome than CSHCN without limitations. More than 10% of Hispanic CSHCN were uninsured at the time of the interview, and 20% of Hispanic CSHCN experienced gaps in coverage. Although insurance met the needs of most families, more than one fourth of... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD health services
KW - CHILD care
KW - PEDIATRICS
KW - CHILDREN -- Health
KW - HEALTH insurance
KW - FAMILIES
N1 - Accession Number: 16786544; Honberg, Lynda 1; Email Address: lhonberg@hrsa.gov McPherson, Merle 1 Strickland, Bonnie 1 Gage, Julia C. 1 Newacheck, Paul W. 2; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland, University of California, San Francisco, California 2: Institute for Health Policy Studies and Department of Pediatrics, University of California, San Francisco, California; Source Info: May2005, Vol. 115 Issue 5, p1233; Subject Term: CHILD health services; Subject Term: CHILD care; Subject Term: PEDIATRICS; Subject Term: CHILDREN -- Health; Subject Term: HEALTH insurance; Subject Term: FAMILIES; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1542/peds.2004-1503
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16786544&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106508244
T1 - Assuring adequate health insurance: results of the National Survey of Children With Special Health Care Needs.
AU - Honberg L
AU - McPherson M
AU - Strickland B
AU - Gage JC
AU - Newacheck PW
Y1 - 2005/05//
N1 - Accession Number: 106508244. Language: English. Entry Date: 20050902. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Chronic Disease -- Economics -- In Infancy and Childhood
KW - Health Services Needs and Demand -- Economics -- In Infancy and Childhood
KW - Insurance, Health
KW - Adolescence
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Female
KW - Health Services Accessibility
KW - Infant
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Multivariate Analysis
KW - Odds Ratio
KW - Patient Satisfaction
KW - Human
SP - 1233
EP - 1239
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 115
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: The purpose of this article is to report the findings of the 2001 National Survey of Children With Special Health Care Needs regarding the extent to which children with special health care needs (CSHCN) have access to public or private health insurance that meets their needs. METHODOLOGY: As part of its effort to develop systems of care for CSHCN, the US Maternal and Child Health Bureau established a health insurance core outcome. Successful attainment was measured on the basis of whether the child met 3 distinct components at the time of the interview: presence of public or private coverage; continuity of coverage over the previous 12 months; and adequacy of coverage. Adequacy of coverage was measured from the family's perspective of whether their insurance covered needed services, covered a reasonable share of costs, and allowed families to see the providers they felt were best for their child. Bivariate and multivariate statistical methods were used to assess independent predictors of respondents meeting the health insurance core outcome. RESULTS: Results of the survey indicated that 59.6% of CSHCN nationally met the health insurance core outcome using the 3 components of presence of insurance coverage, continuity of coverage, and adequacy of coverage. Poverty status, race/ethnicity, and functional ability were significant factors in whether a child met the health insurance core outcome as well as each of the 3 components. Of Hispanic and non-Hispanic black CSHCN, 45.2% and 57.6%, respectively, met the health insurance core outcome, compared with 62.5% of their white counterparts. Children with the most limited functional ability were 50% less likely to meet the health insurance core outcome than CSHCN without limitations. More than 10% of Hispanic CSHCN were uninsured at the time of the interview, and 20% of Hispanic CSHCN experienced gaps in coverage. Although insurance met the needs of most families, more than one fourth of families reported that uncovered costs were not reasonable. Children who did not meet the health insurance core outcome were also more likely to have unmet needs. CONCLUSIONS: Results of the survey demonstrated that although the majority of CSHCN have adequate health insurance, additional work is needed to improve the adequacy of insurance, particularly for children below the poverty line, Hispanic children, and children with the most limited functional ability. The survey results also demonstrated the importance of continuous and adequate health insurance, because children who met the health insurance core outcome had fewer unmet needs.
SN - 0031-4005
AD - Division of Services for Children With Special Health Care Needs, Health Resources and Services Administration, Parklawn Building 18-A-18, 5600 Fishers Lane, Rockville, MD 20857; lhonberg@hrsa.gov
U2 - PMID: 15867029.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106447414
T1 - Cytotoxicity of some Russian ethnomedicinal plants and plant compounds.
AU - Spiridonov NA
AU - Konovalov DA
AU - Arkhipov VV
Y1 - 2005/05//
N1 - Accession Number: 106447414. Language: English. Entry Date: 20060526. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Alternative/Complementary Therapies; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8904486.
KW - Phytochemicals -- Pharmacodynamics
KW - Plants, Medicinal -- Pharmacodynamics
KW - In Vitro Studies
KW - Medicine, Traditional
KW - Russia
KW - Tissue Culture Techniques
KW - Human
SP - 428
EP - 432
JO - Phytotherapy Research
JF - Phytotherapy Research
JA - PHYTOTHER RES
VL - 19
IS - 5
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AB - The cytotoxic action of crude ethanol extracts from 61 plant species used in Russian ethnomedicine for alleviating symptoms of diseases in cancer patients was studied on cultured human lymphoblastoid Raji cells. Extracts from Chelidonium majus, Potentilla erecta, Chamaenerium angustfolium, Filipendula ulmaria and Inula helenium possessed marked cytotoxicity, suppressing the growth of the cells at concentrations of 10 and 50 microg/mL. The cytotoxicity of purified active compounds from selected plant species was evaluated along with pharmaceutical antineoplastic drugs methotrexate, fluorouracil, cyclophosphamide and vinblastine. Sesquiterpene lactones helenin, telekin and artemisinin, aromatic polyacetylene capillin, and alkaloid preparation sanguirythrine suppressed cell growth at concentrations of 1-2 microg/mL, which exceeds the cytotoxicity of cyclophosphamide and fluorouracil.
SN - 0951-418X
AD - Center for Drugs Evaluation and Research, U.S. Food and Drug Administration (HFM-541), Building 29A, Room 3B-20, 29 Lincoln Drive, Bethesda, MD 20892; spiridonov@cber.fda.gov
U2 - PMID: 16106386.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Harrington, Charlene
AU - Crider, Mark C.
AU - Benner, Patricia E.
AU - Malone, Ruth E.
T1 - Advanced Nursing Training in Health Policy: Designing and Implementing a New Program.
JO - Policy, Politics & Nursing Practice
JF - Policy, Politics & Nursing Practice
Y1 - 2005/05//
VL - 6
IS - 2
M3 - Article
SP - 99
EP - 108
SN - 15271544
AB - Although the nursing profession has a growing role in the health policy arena, the rapidly changing health care environment means that clinicians need a sophisticated understanding of health policy. Nurses are assuming leadership roles in advocacy, research, analysis, and policy development, implementation, and evaluation, contributing to a growing need to educate nurses to specialize in health policy research and analysis. This article provides an overview of a new master's and doctoral educational program specializing in health policy for advanced practice nurses who are culturally diverse and sensitive to issues of diversity. The program, currently in its third year of operation at the University of California San Francisco, School of Nursing, is addressing the gap in nursing education and practice expertise in health policy. The program is supported through funding by the Department of Health and Human Services Health Resources and Services Administration, Advanced Nurse Training program. [ABSTRACT FROM AUTHOR]
AB - Copyright of Policy, Politics & Nursing Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTINUING education
KW - NURSING -- Vocational guidance
KW - OCCUPATIONAL training
KW - MEDICAL care
KW - MEDICAL policy
KW - advanced nursing education
KW - graduate education
KW - health policy
N1 - Accession Number: 16903089; Harrington, Charlene 1,2 Crider, Mark C. 3 Benner, Patricia E. 4,5,6 Malone, Ruth E. 7,8; Affiliation: 1: Professor of sociology and nursing and director, Doctoral Nursing Health Policy Specialty Program, Department of Social and Behavioral Sciences, School of Nursing, University of California, San Francisco 2: Principal investigator, Advanced Nurse Training in Health Policy, Health Resources and Services Administration, U.S. Department of Health and Human Services (USDHHS) 3: Project director, Nursing Health Policy PhD and MS programs, Department of Social and Behavioral Sciences, School of Nursing, University of California, San Francisco (UCSF) 4: Professor, Thelma Shobe Endowed Chair in Ethics and Spirituality, University of California, San Francisco 5: Chair, Department of Social and Behavioral Sciences, University of California, San Francisco 6: Coinvestigator, Advanced Nurse Training in Health Policy Grant, Health Resources and Services Administration, USDHHS 7: Associate professor of nursing and health policy, Department of Social and Behavioral Sciences, School of Nursing, University of California, San Francisco 8: Director of the master's Nursing Health Policy Specialty program, Department of Social and Behavioral Sciences, School of Nursing, University of California, San Francisco; Source Info: May2005, Vol. 6 Issue 2, p99; Subject Term: CONTINUING education; Subject Term: NURSING -- Vocational guidance; Subject Term: OCCUPATIONAL training; Subject Term: MEDICAL care; Subject Term: MEDICAL policy; Author-Supplied Keyword: advanced nursing education; Author-Supplied Keyword: graduate education; Author-Supplied Keyword: health policy; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1177/1527154405276070
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106536021
T1 - Injuries and illnesses treated at the World Trade Center, 14 September-20 November 2001.
AU - Perritt KR
AU - Boal WL
Y1 - 2005/05//2005 May-Jun
N1 - Accession Number: 106536021. Corporate Author: The Helix Group Inc.. Language: English. Entry Date: 20051111. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8918173.
KW - Terrorism -- New York
KW - Emergency Medical Services
KW - Rescue Work
KW - Occupational Diseases -- Epidemiology -- New York
KW - Occupational Exposure -- Epidemiology -- New York
KW - Wounds and Injuries -- Epidemiology -- New York
KW - United States Public Health Service
KW - New York
KW - Environmental Illness -- Epidemiology
KW - Environmental Illness -- Classification
KW - Wounds and Injuries -- Classification
KW - Incidence
KW - Injury Pattern
KW - Occupational Diseases -- Classification
KW - Prospective Studies
KW - Descriptive Statistics
KW - Adolescence
KW - Adult
KW - Middle Age
KW - Aged
KW - Female
KW - Male
KW - Human
SP - 177
EP - 183
JO - Prehospital & Disaster Medicine
JF - Prehospital & Disaster Medicine
JA - PREHOSPITAL DISASTER MED
VL - 20
IS - 3
PB - Cambridge University Press
AB - INTRODUCTION: In response to the 11 September 2001 terrorist attacks on the World Trade Center (WTC), the United States Public Health Service (USPHS) deployed Disaster Medical Assistance Teams (DMATs) and the Commissioned Corps to provide on-site, primary medical care to anyone who presented. Patients included rescue and recovery workers, other responders, and some members of the general public. OBJECTIVE: A descriptive analysis of WTC-USPHS patient records was conducted in order to better understand the short-term impact of the WTC site on the safety and health of individuals who were at or near the site from 14 September-20 November 2001. METHODS: The Patient Treatment Record forms that were completed for each patient visit to these USPHS stations over the 10-week deployment period were reviewed. Results: Patient visits numbered 9,349, with visits peaking during Week 2 (21-27 September). More than one-quarter of the visits were due to traumatic injuries not including eye injuries (n = 2,716; 29%). Respiratory problems comprised more than one-fifth of the complaints (n = 2,011; 22%). Eye problems were the third most frequent complaint (n = 1,120; 12%). With respect to the triage class, the majority of visits fell into the lowest category of severity (n = 6,237; 67%). CONCLUSION: USPHS visits probably were skewed to milder complaints when compared to analyses of employer medical department reports or hospital cases; however, given the close proximity of the USPHS stations to the damage, analysis of the USPHS forms provides a more complete picture of the safety and health impact on those who were at or near the WTC site.
SN - 1049-023X
AD - Chief, Special Studies Team, Surveillance and Field Investigation Branch, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 1808, Morgantown, WV, 26505 USA; kperritt@cdc.gov
U2 - PMID: 16018506.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sullivan, Patrick S.
AU - Karon, John M.
AU - Fleming, Patricia L.
AU - Malitz, Faye E.
AU - Broyles, Stephanie
AU - Mokotoff, Eve D.
AU - Buskin, Susan E.
T1 - A Two-Stage Sampling Method for Clinical Surveillance of Individuals in Care for HIV Infection in the United States.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005/05//May/Jun2005
VL - 120
IS - 3
M3 - Article
SP - 230
EP - 239
SN - 00333549
AB - Objectives. The goals of this study were two-fold: (1) to describe methods for drawing a population-based sample of individuals in care for HIV infection and (2) to compare data from the sample with data from existing surveillance systems that describe care for HIV. Methods. The authors implemented a two-stage sampling method, using local HIV/AIDS surveillance data as a sampling frame of HIV care providers in three states. At selected providers, medical records of a random sample of patients were abstracted. Results. The medical records of a number of patients, ranging from 253 to 374 individuals per state, were abstracted. The demographics of sampled individuals and of individuals reported to the local HIV/AIDS surveillance program were similar; however, differences existed in the proportion of individuals receiving HIV care consistent with treatment guidelines between the sample and a contemporary facility-based supplemental surveillance project. The median design effect for outcomes collected in the sample was 1.8 (range=0.5-29.6). Conclusions. This survey method is feasible for collecting population-based data on patients in care for HIV. Sample size and some design elements should be changed in future studies to increase precision of estimates and usefulness of data for local planning and evaluation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - PUBLIC health surveillance
KW - MEDICAL care
KW - PUBLIC health
KW - HIV infections
KW - UNITED States
N1 - Accession Number: 16998972; Sullivan, Patrick S. 1; Email Address: pss0@cdc.gov Karon, John M. 1 Fleming, Patricia L. 1 Malitz, Faye E. 2 Broyles, Stephanie 3 Mokotoff, Eve D. 4 Buskin, Susan E. 5; Affiliation: 1: Division of HIV/AIDS Prevention--Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 2: Office of Science and Epidemiology, HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, MD 3: HIV/AIDS Surveillance Program, Louisiana Office of Public Health, New Orleans, LA 4: HIV/AIDS Surveillance, Michigan Department of Community Health, Detroit and Lansing, MI 5: Public Health--Seattle & King County; Department of Epidemiology, University of Washington, Seattle, WA; Source Info: May/Jun2005, Vol. 120 Issue 3, p230; Subject Term: HIV-positive persons; Subject Term: PUBLIC health surveillance; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: HIV infections; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krieg Jr., Edward F.
AU - Chrislip, David W.
AU - Crespo, Carlos J.
AU - Brightwell, W. Stephen
AU - Ehrenberg, Richard L.
AU - Otto, David A.
T1 - The Relationship Between Blood Lead Levels and Neurobehavioral Test Performance in NHANES III and Related Occupational Studies.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005/05//May/Jun2005
VL - 120
IS - 3
M3 - Article
SP - 240
EP - 251
SN - 00333549
AB - Objectives. The goals of this study were two-fold: (1) to assess the relationship between blood lead levels and neurobehavioral test performance in a nationally representative sample of adults from the third National Health and Nutrition Evaluation Survey and (2) to analyze the results from previously published studies of occupational lead exposure that used the same neurobehavioral tests as those included in the survey. Methods. Regression models were used to test and estimate the relationships between measurements of blood lead and performance on a simple reaction time, a symbol-digit substitution, and a serial digit learning test in adults aged 20-59 years who participated the survey. Mixed models were used to analyze the data from the occupational studies. Results. The blood lead levels of those participating in the survey ranged from 0.7 to 41.8 µg/dl. The estimated geometric mean was 2.51 µg/dl, and the estimated arithmetic mean was 3.30 µg/dl. In the survey, no statistically significant relationships were found between blood lead concentration and performance on the three neurobehavioral tests when adjusted for covariates. In the occupational studies, the groups exposed to lead consistently performed worse than control groups on the simple reaction time and digit-symbol substitution tests. Conclusions. The results from the survey and the occupational studies do not provide evidence for impairment of neurobehavioral test performance at levels below 25 µg/dl, the concentration that the Centers for Disease Control and Prevention define as elevated in adults. The average blood lead level of the exposed groups in the occupational studies was 41.07 µg/dl, less than 50 µg/dl, the minimum concentration that the Occupational Safety and Health Administration requires for medical removal from the workplace. Given the evidence of impaired neurobehavioral performance in these groups, the 50 µg/dl limit should be reevaluated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAD in the body
KW - BEHAVIORAL toxicology
KW - HEALTH surveys
KW - PUBLIC health
KW - INDUSTRIAL hygiene
N1 - Accession Number: 16998973; Krieg Jr., Edward F. 1; Email Address: erk3@cdc.gov Chrislip, David W. 1 Crespo, Carlos J. 2 Brightwell, W. Stephen 1 Ehrenberg, Richard L. 3 Otto, David A. 4; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH 2: State University of New York at Buffalo, Buffalo, NY 3: Office of the Director, National Institute for Occupational Safety and Health, Cincinnati, OH 4: U.S. Environmental Protection Agency, Washington, DC; Source Info: May/Jun2005, Vol. 120 Issue 3, p240; Subject Term: LEAD in the body; Subject Term: BEHAVIORAL toxicology; Subject Term: HEALTH surveys; Subject Term: PUBLIC health; Subject Term: INDUSTRIAL hygiene; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leman, Richard F.
AU - Espey, David
AU - Cobb, Nathaniel
T1 - Invasive Cervical Cancer Among American Indian Women in the Northern Plains, 1994-1998: Incidence, Mortality, and Missed Opportunities.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005/05//May/Jun2005
VL - 120
IS - 3
M3 - Article
SP - 283
EP - 287
SN - 00333549
AB - Objectives. Cervical cancer mortality rates among the American Indian and Alaska Native (AI/AN) population in North and South Dakota were five times the national average (15.6 per 100,000 vs. 3.1 per 100,000, age adjusted) when last evaluated (from 1989 through 1993). Our goals were to update the AI/AN population cervical cancer mortality rates and to present incidence rates for AI/AN women in the region. Methods. We reviewed charts for women diagnosed with invasive cervical cancer at Indian Health Service (IHS) facilities in North and South Dakota from 1994 through 1998 and collected information about cervical cancer screening and treatment history. Incidence and mortality rates were standardized to the 1970 U.S. population. Results. Twenty-one cases of invasive cervical cancer and eight deaths were identified. Annualized incidence and mortality rates were 11.5 per 100,000 and 4.5 per 100 000. These compare with national all-race/ethnicity rates of 8.5 per 100,000 and 2.7 per 100,000 for incidence and mortality. Fifteen (71%) of 21 cases were diagnosed due to symptoms. Conclusions. While cervical cancer mortality rates have declined, incidence and mortality rates among AI/AN women remain higher than in the general U.S. population. Increased use of pap tests and careful follow-up of abnormal results should be aggressively promoted among AI/AN women in North and South Dakota. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CERVICAL cancer
KW - CANCER -- Mortality
KW - MORTALITY
KW - CANCER in women
KW - INDIGENOUS women -- America
KW - UNITED States
N1 - Accession Number: 16998979; Leman, Richard F. 1,2,3; Email Address: Richard.f.leman@state.or.us Espey, David 3,4 Cobb, Nathaniel 3; Affiliation: 1: Oregon Health Services/Health Promotion and Chronic Disease Prevention Program, Portland, OR 2: Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers For Disease Control and Prevention, Atlanta, GA 3: National Epidemiology Program, Indian Health Service, Albuquerque, NM 4: Epidemiology and Health Services Research Branch, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA; Source Info: May/Jun2005, Vol. 120 Issue 3, p283; Subject Term: CERVICAL cancer; Subject Term: CANCER -- Mortality; Subject Term: MORTALITY; Subject Term: CANCER in women; Subject Term: INDIGENOUS women -- America; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106544013
T1 - The relationship between blood lead levels and neurobehavioral test performance in NHANES III and related occupational studies.
AU - Krieg EF Jr.
AU - Chrislip DW
AU - Crespo CJ
AU - Brightwell WS
AU - Ehrenberg RL
AU - Otto DA
Y1 - 2005/05//May/Jun2005
N1 - Accession Number: 106544013. Language: English. Entry Date: 20051125. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Instrumentation: Neurobehavioral Evaluation System 2. NLM UID: 9716844.
KW - Employee Performance Appraisal
KW - Lead Poisoning -- Blood -- In Adulthood
KW - Neurobehavioral Manifestations -- Evaluation
KW - Occupational Exposure
KW - Occupational Health
KW - Adult
KW - Behavior Rating Scales
KW - Clinical Assessment Tools
KW - Clinical Indicators
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Effect Size
KW - Lead -- Blood
KW - Linear Regression
KW - Middle Age
KW - P-Value
KW - Probability Sample
KW - Reaction Time
KW - Regression
KW - Spectrum Analysis
KW - Surveys
KW - Time Factors
KW - Human
SP - 240
EP - 251
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 120
IS - 3
PB - Sage Publications Inc.
AB - OBJECTIVES: The goals of this study were two-fold: (1) to assess the relationship between blood lead levels and neurobehavioral test performance in a nationally sample of adults from the third National Health and Nutrition Evaluation Survey and (2) to analyze the results from previously published studies of occupational lead exposure that used the same neurobehavioral tests as those included in the survey. METHODS: Regression models were used to test and estimate the relationships between measurements of blood lead and performance on a simple reaction time, a symbol-digit substitution, and a serial digit learning test in adults aged 20-59 years who participated the survey. Mixed models were used to analyze the data from the occupational studies. RESULTS: The blood lead levels of those participating in the survey ranged from 0.7 to 41.8 microg/dl. The estimated geometric mean was 2.51 microg/dl, and the estimated arithmetic mean was 3.30 microg/dl. In the survey, no statistically significant relationships were found between blood lead concentration and performance on the three neurobehavioral tests when adjusted for covariates. In the occupational studies, the groups exposed to lead consistently performed worse than control groups on the simple reaction time and digit-symbol substitution tests. CONCLUSIONS: The results from the survey and the occupational studies do not provide evidence for impairment of neurobehavioral test performance at levels below 25 microg/dl, the concentration that the Centers for Disease Control and Prevention define as elevated in adults. The average blood lead level of the exposed groups in the occupational studies was 41.07 microg/dl, less than 50 microg/dl, the minimum concentration that the Occupational Safety and Health Administration requires for medical removal from the workplace. Given the evidence of impaired neurobehavioral performance in these groups, the 50 microg/dl limit should be reevaluated.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health, Robert A Taft Laboratories, 4676 Columbia Pkwy, MS C-22, Cincinnati, OH 45226; erk3@cdc.gov
U2 - PMID: 16134563.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wagner, Robert F.
T1 - LESSONS FROM MY DINNERS WITH THE GIANTS OF MODERN IMAGE SCIENCE.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2005/05//
VL - 114
IS - 1-3
M3 - Article
SP - 4
EP - 10
SN - 01448420
AB - The author traces some critical moments in the history of Image Science in the last half century from first-hand or once-removed experience. The Image Science used in the field of medical imaging today had its origins in the analysis of photon detection developed for modern television, conventional photography, and the human visual system. Almost all "model observers" used in image assessment today converge to the model originally used by Albert Rose in his analysis of those classic photo-detectors. A more general statistical analysis of the various "defects" of conventional and unconventional photon-imaging technologies was provided by Shaw. A number of investigators in medical imaging elaborated the work of these pioneers into a synthesis with the general theory of signal detectability and extended this work to the various forms of CT, energy-spectral-dependent imaging, and the further complication of anatomical-background-noise limited imaging. The author calls for further extensions of this work to the problem of under-sampled and thus artefact-limited imaging that will be important issues for high-speed CT and MRI. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diagnostic imaging
KW - Photons
KW - Detectors
KW - Eye
KW - Medical photography
KW - Imaging systems in medicine
N1 - Accession Number: 18069353; Wagner, Robert F. 1; Email Address: rfw@cdrh.fda.gov; Affiliations: 1: Center for Devices and Radiological Health/FDA, HFZ-142, Rockville, MD 20850, USA.; Issue Info: 2005, Vol. 114 Issue 1-3, p4; Subject Term: Diagnostic imaging; Subject Term: Photons; Subject Term: Detectors; Subject Term: Eye; Subject Term: Medical photography; Subject Term: Imaging systems in medicine; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 541920 Photographic services; NAICS/Industry Codes: 541922 Commercial Photography; Number of Pages: 7p; Document Type: Article
L3 - 10.1093/rpd/nch503
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 119722046
T1 - Absolute stroke mortality burden for non-Hispanic non-Latino whites was disproportionately higher than expected simply based on the US population in 2001.
AU - Fields, Larry E
Y1 - 2005/05//2005 May
N1 - Accession Number: 119722046. Language: English. Entry Date: 20060113. Revision Date: 20161126. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Instrumentation: Impact of Events Scale (IES). NLM UID: 0235266.
KW - Stroke -- Ethnology
KW - Whites
KW - Stroke -- Mortality
KW - United States
KW - Hispanics
KW - Impact of Events Scale
SP - e48
EP - e49
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 36
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background and Purpose: The absolute burden of stroke is a major determinant of health care costs and should also be considered when developing and implementing effective health policy. This study evaluated the impact of specific racial-ethnic categorization on absolute stroke mortality burden and population percentages.Methods: In this population-based analysis, 2001 US data was used to compute absolute values of population and stroke mortality burden for white and black, and other racial-ethnic groups. To test the effect of age-mix, values were age-adjusted using the 2000 US standard population. The z test statistic was computed and a 2-tailed P value of <0.05 was considered significant.Result: Whites comprised a majority of the 2001 absolute US stroke mortality burden and US population (86% and 82%, respectively). Surprisingly, nHnL whites comprised a much higher percentage of the absolute US stroke mortality burden than expected based on their percentage of the US population alone (81% and 69%, respectively; P<0.001). Age-adjustment indicated a contribution by age-mix, however, an age-independent residual component remained.Conclusions: Specific race-ethnicity categorization significantly influences comparisons of the proportion of absolute stroke mortality burden to the population proportion. Accordingly, appropriate caution and care are needed when estimating the societal impact of conditions such as stroke.
SN - 0039-2499
AD - Office of Public Health and Science of the Office of the Secretary, US Department of Health and Human Services, Washington, DC 20201, USA
U2 - PMID: 15817894.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wassell, James T.
T1 - Sensitivity Analysis in Practice.
JO - Technometrics
JF - Technometrics
Y1 - 2005/05//
VL - 47
IS - 2
M3 - Book Review
SP - 236
EP - 237
SN - 00401706
AB - Reviews the book "Sensitivity Analysis in Practice," by Andrea Saltelli, Stefano Tarantola, Francesca Campolongo and Marco Ratto.
KW - ANALYSIS of variance
KW - NONFICTION
KW - SALTELLI, Andrea
KW - TARANTOLA, Stefano
KW - CAMPOLONGO, Francesca
KW - RATTO, Marco
KW - SENSITIVITY Analysis in Practice: A Guide to Assessing Scientific Models (Book)
N1 - Accession Number: 16964846; Wassell, James T. 1; Affiliation: 1: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention.; Source Info: May2005, Vol. 47 Issue 2, p236; Subject Term: ANALYSIS of variance; Subject Term: NONFICTION; Reviews & Products: SENSITIVITY Analysis in Practice: A Guide to Assessing Scientific Models (Book); People: SALTELLI, Andrea; People: TARANTOLA, Stefano; People: CAMPOLONGO, Francesca; People: RATTO, Marco; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Muskhelishvili, Levan
AU - Wingard, Susan K.
AU - Latendresse, John R.
T1 - Proliferating Cell Nuclear Antigen—A Marker for Ovarian Follicle Counts.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2005/05//
VL - 33
IS - 3
M3 - Article
SP - 365
EP - 368
SN - 01926233
AB - Enumerating ovarian follicles is an effective way to estimate the extent of ovarian toxicity in female rodents exposed to xenobiotics. Differential follicle counts are useful in safety assessment bioassays and in interspecies extrapolation of ovarian toxicity. Counting the follicles in H&E-stained sections is labor intensive, tedious, and costly. In the present study we demonstrated that in rat formalin-fixed, paraffin-embedded ovary sections follicles of all degrees of maturity can be visualized by the use of antibody directed against proliferating cell nuclear antigen (PCNA). Follicles are easily distinguished from ovarian background with the ability to detect and identify primordial follicles being enhanced. This translates into a significant decrease in variability of follicle counts, labor, and cost. Specifically, variability dropped from 11% to 0.2%, the counting time was reduced by 46%, and the cost by 48%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - DISEASES
KW - Immunohistochemistry
KW - Ovaries
KW - Women
KW - Gynecology
KW - counts
KW - counts.
KW - immunohistochemistry
KW - ovarian follicles
KW - PCNA
N1 - Accession Number: 20188257; Muskhelishvili, Levan 1; Email Address: lmuskhelishvili@nctr.fda.gov; Wingard, Susan K. 1; Latendresse, John R. 1; Affiliations: 1: Toxicologic Pathology Associates at National Center for Toxicological Research, Jefferson, Arkansas 72079, USA; Issue Info: 2005, Vol. 33 Issue 3, p365; Thesaurus Term: Toxicology; Thesaurus Term: DISEASES; Subject Term: Immunohistochemistry; Subject Term: Ovaries; Subject Term: Women; Subject Term: Gynecology; Author-Supplied Keyword: counts; Author-Supplied Keyword: counts.; Author-Supplied Keyword: immunohistochemistry; Author-Supplied Keyword: ovarian follicles; Author-Supplied Keyword: PCNA; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: Article
L3 - 10.1080/01926230590930164
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Siegel, Joanna E.
AU - Byron, Sepheen C.
AU - Lawrence, William F.
T1 - Federal Sponsorship of Cost-Effectiveness and Related Research in Health Care: 1997–2001.
JO - Value in Health
JF - Value in Health
Y1 - 2005/05//May/Jun2005
VL - 8
IS - 3
M3 - Article
SP - 223
EP - 236
PB - Elsevier Science
SN - 15244733
AB - To describe recent federal sponsorship of cost-effectiveness and related health economics research to provide insight into the functioning of existing research support systems and assess the roles of federal health agencies.Using the PubMed database, we identified cost-effectiveness and related publications citing support from a US government entity and published during the period of 1997 through 2001, and audited them for information on funding sources, study type, and content focus.Five Department of Health and Human Services agencies and centers and the Veterans Administration are cited as funders in 74% of 520 federally supported health economics publications we identified. Three-fourths of federally supported publications address five areas of high disease burden: infections, cancer, HIV/AIDS, cardiovascular disease, and substance abuse. Other high burden diseases, including mental health, diabetes, and injuries, receive less attention. Federal support of health economics studies of health education and care delivery—intervention types underexamined in the field—is relatively strong but most often focuses on substance abuse or mental health services. Each of the top federal funders has a distinct funding pattern, but there are substantial areas of overlap within which we could not identify content domains specific to one funder or another.Federal support of health economics research has paralleled growth in the field. Federal funders support projects consistent with their mission and focus on high-burden disease areas. However, overlapping funding areas, ambiguity concerning agency interests within overlapping content areas, and gaps in some disease and intervention areas suggest that the coordination of health economics research funding could be improved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Value in Health is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COST effectiveness
KW - INDUSTRIAL costs
KW - MEDICAL economics
KW - PUBLIC welfare
KW - DOMESTIC economic assistance
KW - FEDERAL aid to medical research
KW - FEDERAL aid to health facilities
KW - cost-effectiveness
KW - federal funding
KW - federal health agencies
KW - health economics
KW - research priorities
N1 - Accession Number: 16792709; Siegel, Joanna E. 1; Email Address: siegel@AHRQ.gov Byron, Sepheen C. 1 Lawrence, William F. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: May/Jun2005, Vol. 8 Issue 3, p223; Subject Term: COST effectiveness; Subject Term: INDUSTRIAL costs; Subject Term: MEDICAL economics; Subject Term: PUBLIC welfare; Subject Term: DOMESTIC economic assistance; Subject Term: FEDERAL aid to medical research; Subject Term: FEDERAL aid to health facilities; Author-Supplied Keyword: cost-effectiveness; Author-Supplied Keyword: federal funding; Author-Supplied Keyword: federal health agencies; Author-Supplied Keyword: health economics; Author-Supplied Keyword: research priorities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 14p; Document Type: Article
L3 - 10.1111/j.1524-4733.2005.04037.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106411072
T1 - Federal sponsorship of cost-effectiveness and related research in health care: 1997-2001.
AU - Siegel JE
AU - Byron SC
AU - Lawrence WF
Y1 - 2005/05//May/Jun2005
N1 - Accession Number: 106411072. Language: English. Entry Date: 20060317. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 100883818.
KW - Economics
KW - Health
KW - Research Support -- Economics
KW - Centers for Disease Control and Prevention (U.S.)
KW - Cost Benefit Analysis
KW - Grants
KW - National Institute of Mental Health (U.S.)
KW - National Institutes of Health (U.S.)
KW - Organizational Structure
KW - PubMed
KW - Research Priorities
KW - Research, Medical
KW - United States
KW - United States Department of Health and Human Services
KW - United States Department of Veterans Affairs
KW - Funding Source
KW - Human
SP - 223
EP - 236
JO - Value in Health
JF - Value in Health
JA - VALUE HEALTH
VL - 8
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1524-4733
AD - Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 15877594.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lugovtsev, Vladimir Y.
AU - Vodeiko, Galina M.
AU - Levandowski, Roland A.
T1 - Mutational pattern of influenza B viruses adapted to high growth replication in embryonated eggs
JO - Virus Research
JF - Virus Research
Y1 - 2005/05//
VL - 109
IS - 2
M3 - Article
SP - 149
EP - 157
SN - 01681702
AB - Abstract: Improved replication of influenza viruses in embryonated chicken eggs (CE) permits increased vaccine production and availability. We investigated the growth properties of influenza B viruses in relation to specific mutations occurring after serial passage in CE. In serial passage experiments yielding high growth variants of B/Victoria/504/2000, mutations predicted to alter amino acid (AA) composition occurred only near the receptor-binding pocket of the hemagglutinins (HA) and in no other genes. Two B/Victoria/504/2000 high growth variants had the same AA substitutions in HA (R162M and D196Y), but the higher yield variant had a third substitution (G141E), which also altered antigenic characteristics. In a serial passage experiment yielding a high growth variant of B/Hong Kong/330/2001, mutations predicted to alter AA composition occurred only in PB2 and NP in domains predicted to relate to RNP formation and function. Our results indicate that adaptation of influenza B viruses to high-yield replication by serial passage in CE requires few mutations either in internal or external genes. Specific modifications of genes or a combination of genes could be used to optimize or create influenza B viruses for specific growth substrates. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - RESPIRATORY infections
KW - MICROORGANISMS
KW - INFLUENZA viruses
KW - Adaptation
KW - Genotype
KW - Growth characteristics
KW - Influenza B virus
N1 - Accession Number: 17462969; Lugovtsev, Vladimir Y.; Email Address: lugovtsev@cber.fda.gov Vodeiko, Galina M. 1 Levandowski, Roland A. 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: May2005, Vol. 109 Issue 2, p149; Subject Term: INFLUENZA; Subject Term: RESPIRATORY infections; Subject Term: MICROORGANISMS; Subject Term: INFLUENZA viruses; Author-Supplied Keyword: Adaptation; Author-Supplied Keyword: Genotype; Author-Supplied Keyword: Growth characteristics; Author-Supplied Keyword: Influenza B virus; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virusres.2004.11.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17462969&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thorpe, S. J.
AU - Fox, B.
AU - Heath, A.
AU - Dolman, C.
AU - Virata, M. L.
AU - Yu, M. W.
AU - Thorpe, R.
T1 - International collaborative study to evaluate a candidate reference preparation to define an appropriate specified limit of anti-D in intravenous immunoglobulin products.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2005/05//
VL - 88
IS - 4
M3 - Article
SP - 278
EP - 287
PB - Wiley-Blackwell
SN - 00429007
AB - The aim of the study was to evaluate a lyophilized intravenous immunoglobulin (IVIG) preparation containing anti-D (02/228; nominal reciprocal titre of 8) for its suitability to define the maximum limit of anti-D in IVIG products when used in a proposed reference method of direct haemagglutination of papain-treated erythrocytes, in an international collaborative study.Twenty laboratories tested 02/228 along with a negative control IVIG preparation and four IVIG samples containing different levels of anti-D. Nineteen laboratories performed direct haemagglutination methodology using papain-treated erythrocytes; five of these laboratories and one additional laboratory performed their in-house haemagglutination methodology (all indirect antiglobulin tests).The mode titre of 02/228, obtained by using the proposed reference method, was 8 (62·5% of tests). However, there was wide variation in haemagglutination titres between laboratories for three of the four samples. Correcting the titres of the samples relative to those of the proposed reference preparation reduced the interlaboratory variability and increased the frequency of the mode titres in three out of four samples. The indirect antiglobulin tests also showed wide interlaboratory variability and were less sensitive than the direct method in four laboratories. Eleven of the 14 laboratories that expressed an opinion considered that the level of anti-D in 02/228 was appropriate to define a specified limit.Our results demonstrate the necessity of using a reference preparation to define the maximum level of anti-D in IVIG products and ensure sufficient sensitivity in haemagglutination testing methodology. On the basis of these results, members of the European Pharmacopoeia Expert Group 6B recommended revision of the appropriate monograph to include this new specification and test. The Food and Drug Administration in the USA intends to adopt the same maximal specification defined by the reference preparation and to recommend the same test for the safety of IVIG products. Preparations 02/228 and 02/226 were also established by the World Health Organization as International Reference Reagents to standardize haemagglutination testing for anti-D in normal IVIG products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - AGGLUTINATION of blood
KW - BLOOD groups
KW - INTRAVENOUS therapy
KW - ERYTHROCYTES
KW - anti-D
KW - haemagglutination
KW - IVIG
KW - reference method
KW - specification
N1 - Accession Number: 16975353; Thorpe, S. J. 1; Email Address: sthorpe@nibsc.ac.uk Fox, B. 2 Heath, A. 2 Dolman, C. 2 Virata, M. L. 3 Yu, M. W. 3 Thorpe, R. 2; Affiliation: 1: Division of Haematology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK 2: National Institute for Biological Standards and Control, Potters Bar, Herts, UK 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: May2005, Vol. 88 Issue 4, p278; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: AGGLUTINATION of blood; Subject Term: BLOOD groups; Subject Term: INTRAVENOUS therapy; Subject Term: ERYTHROCYTES; Author-Supplied Keyword: anti-D; Author-Supplied Keyword: haemagglutination; Author-Supplied Keyword: IVIG; Author-Supplied Keyword: reference method; Author-Supplied Keyword: specification; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1423-0410.2005.00622.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16975353&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Coste, J.
AU - Reesink, H. W.
AU - Engelfriet, C. P.
AU - Laperche, S.
AU - Brown, S.
AU - Busch, M. P.
AU - Cuijpers, H. T.
AU - Eglin, R.
AU - Ekermo, B.
AU - Epstein, J. S.
AU - Flesland, O.
AU - Heier, H. E.
AU - Henn, G.
AU - Hernandez, J. M.
AU - Hewlett, I. K.
AU - Hyland, C.
AU - Keller, A. J.
AU - Krusius, T.
AU - Levičnik-Stezina, S.
AU - Levy, G.
T1 - International Forum: 1.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2005/05//
VL - 88
IS - 4
M3 - Other
SP - 289
EP - 298
PB - Wiley-Blackwell
SN - 00429007
AB - Discusses the results of a survey on the implementation of Hepatitis C virus (HCV) nucleic acid amplification technology (NAT) in testing of blood donations in eighteen countries. Number of countries who have implemented HCV NAT; Alternatives used by countries whose HCV NAT are yet to be approved; Characteristics of NAT assays.
KW - HEPATITIS C virus
KW - HEALTH surveys
KW - BLOOD collection
KW - MICROBIOLOGICAL assay
KW - MEDICAL screening
KW - HEALTH risk assessment
N1 - Accession Number: 16975344; Coste, J. 1,2; Email Address: joliette.coste@efs.sante.fr Reesink, H. W. 3; Email Address: h.reesink@sanquin.nl Engelfriet, C. P. 4; Email Address: p.engelfriet@sanquin.nl Laperche, S. 5,6; Email Address: slaperche@ints.fr Brown, S. 7 Busch, M. P. 8; Email Address: mpbusch@itsa.ucsf.edu Cuijpers, H. T. 9; Email Address: t.cuijpers@sanquin.nl Eglin, R. 10; Email Address: roger.eglin@nbs.nhs.uk Ekermo, B. 11; Email Address: bengt.ekermo@lio.se Epstein, J. S. 12 Flesland, O. 13; Email Address: oystein.flesland@rikshospitalet.no Heier, H. E. 14; Email Address: hanserik.heier@ulleval.no Henn, G. 15; Email Address: gabriela.henn@roteskreuz.at Hernandez, J. M. 16; Email Address: jmhernandez@vhebron.net Hewlett, I. K. 12 Hyland, C. 7; Email Address: chyland@arcbs.redcross.org.au Keller, A. J. 7 Krusius, T. 17; Email Address: tom.krusius@bts.redcross.fi Levičnik-Stezina, S. 18; Email Address: snezna.levicnik@ztm.si Levy, G. 19; Email Address: guy.levy@redcross.ch; Affiliation: 1: EFS Pyrénées-Mediterranée Laboratoire de R&D Agents Transmissibles par Tranfusion 240 Av Emile Jeanbraug F-34000 Montpellier France 2: R&D – Agents Transmissibles par Transfusion Etablissement Français du Sang de Pyrénées-Méditerranée, 240 Avenue Emile Jeanbrau, F-34094 Montpellier, Cedex 5 3: Sanquin Blood Bank North-West and Sanquin Diagnostic Services PO Box 9137, NL-1006 AC Amsterdam the Netherlands 4: Sanquin Research and Sanquin Diagnostic Services PO Box 9190, NL-1006 AD Amsterdam the Netherlands 5: Centre National de référence pour les hépatites B et C en transfusion Institut National de la Transfusion Sanguine 6, rue Alexandre Cabanel F-75739 Paris, Cedex France 6: Centres National de Référence pour les Hepatites B et C en Transfusion Department des Agents Transmissibles par le Sang Institut National de la Transfusion Sanguine 6, rue Alexandre Cabanel, F-75015 Paris Cedex 7: Australian Red Cross Blood Service 480 Queen Street, Brisbane 8: Blood Systems Research Institute San Francisco, CA 9: Sanquin Diagnostic Services, PO Box 9190, NL-1066 AD Amsterdam 10: National Blood Service Colindale Avenue, London, NW9 5BG 11: University Hospital, Department of Transfusion Medicine SE-58185 Linköping 12: Food and Drug Administration Rockville, MD 13: Institute of Immunology, Rikshospitalet University Hospital N-0027 Oslo 14: Ullevål University Hospital, Dept. of Immunology and Transfusion Medicine N-0407 Oslo 15: Blood Donation Center for Vienna, Lower Austria and Burgenland Wiedner Hauptstrasse 32, A-1040 Vienna 16: Centre de Transfusió I Banc de Teixits P. Vall d'Hebrón, 119-129, E-08035 Barcelona 17: Finnish Red Cross Blood Services, Blood and Blood Components Kivihaantie 7, F-00310 Helsinki 18: Head of Centre for Testing Blood of Blood Donors Blood Transfusion Centre of Slovenia Slajmerjeva 6 Sl-1000 Ljubljana 19: Blood Transfusion Service SRC Gutenbergstrasse 14 Postfach 5510 3001 Bern; Source Info: May2005, Vol. 88 Issue 4, p289; Subject Term: HEPATITIS C virus; Subject Term: HEALTH surveys; Subject Term: BLOOD collection; Subject Term: MICROBIOLOGICAL assay; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Other
L3 - 10.1111/j.1423-0410.2005.00636_1.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=16975344&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-03100-002
AN - 2005-03100-002
AU - Eggerth, Donald E.
AU - Bowles, Shannon M.
AU - Tunick, Roy H.
AU - Andrew, Michael E.
T1 - Convergent Validity of ONET Holland Code Classifications.
JF - Journal of Career Assessment
JO - Journal of Career Assessment
JA - J Career Assess
Y1 - 2005/05//
VL - 13
IS - 2
SP - 150
EP - 168
CY - US
PB - Sage Publications
SN - 1069-0727
SN - 1552-4590
AD - Eggerth, Donald E., Training Research and Evaluation Branch, CDC/NIOSH, 4676 Columbia Parkway, C-10, Cincinnati, OH, US, 45226
N1 - Accession Number: 2005-03100-002. Partial author list: First Author & Affiliation: Eggerth, Donald E.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20050404. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Classification (Cognitive Process); Occupational Guidance; Test Validity. Classification: Occupational & Employment Testing (2228); Occupational Interests & Guidance (3610). Population: Human (10). Location: Netherlands. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: May, 2005.
AB - The interpretive ease and intuitive appeal of the Holland RIASEC typology have made it nearly ubiquitous in vocational guidance settings. Its incorporation into the Occupational Information Network (ONET) has moved it another step closer to reification. This research investigated the rates of agreement between Holland code classifications from three major sources. The Holland code classifications from the ONET were compared with those from the Strong Interest Inventory and the Dictionary of Holland Occupational Types using six different methods. The mean pairwise rate of agreement for the first Holland code letter was 70.6%, with a three-way rate of agreement of 60.21%. The mean pairwise rate of agreement for the first and second Holland code letters was 32.33%, with a three-way rate of agreement of 15.71%. The mean pairwise rate of agreement for the first, second, and third Holland code letters was 12.56%, with a three-way rate of agreement of 2.62%. The implications of these findings for research and counseling practice are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Holland code classifications
KW - test validity
KW - vocational guidance
KW - occupational information network
KW - convergent validity
KW - 2005
KW - Classification (Cognitive Process)
KW - Occupational Guidance
KW - Test Validity
KW - 2005
DO - 10.1177/1069072704273124
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-03100-002&site=ehost-live&scope=site
UR - eggerth@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04329-001
AN - 2005-04329-001
AU - Brown, David R.
AU - Wang, Guijing
AU - Safran, Marc A.
T1 - A Preliminary Analysis of Medical Expenditures Among Active and Sedentary US Adults With Mental Disorders.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2005/05//May-Jun, 2005
VL - 29
IS - 3
SP - 195
EP - 205
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Brown, David R., Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition and Physical Activity, Physical Activity and Health Branch, MS, K-46, 4770 Buford Hwy, N.E., Atlanta, GA, US, 30341-3724
N1 - Accession Number: 2005-04329-001. PMID: 15899683 Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Brown, David R.; Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition and Physical Activity, Physical Activity and Health Branch, Atlanta, GA, US. Release Date: 20050613. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Exercise; Health Care Costs; Leisure Time; Mental Disorders. Minor Descriptor: Motor Processes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: May-Jun, 2005.
AB - Objective: To determine whether leisure-time physical activity is associated with lower direct annual medical expenditures among a sample of adults with mental disorders. Methods: Using the 1995 National Health Interview Survey and 1996 Medical Expenditure Panel Survey, differences between medical expenditures for sedentary and active persons were analyzed using t-tests. Results: The per capita annual direct medical expenditure was $2785 higher for sedentary than for active persons (P<0.05). The total expenditure associated with sedentary behavior was $31.7 billion ($19.1 billion in men; $12.6 billion in women). Conclusions: Physical activity is associated with a reduced economic burden among people with mental disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical expenditures
KW - mental disorders
KW - leisure
KW - physical activity
KW - economic burden
KW - 2005
KW - Activity Level
KW - Exercise
KW - Health Care Costs
KW - Leisure Time
KW - Mental Disorders
KW - Motor Processes
KW - 2005
DO - 10.5993/AJHB.29.3.1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04329-001&site=ehost-live&scope=site
UR - DBrown@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-05204-011
AN - 2005-05204-011
AU - Wright, Douglas
AU - Bobashev, Georgiy V.
AU - Novak, Scott P.
T1 - Decomposing the total variation in a nested random effects model of neighborhood, household, and individual components when the dependent variable is dichotomous: Implications for adolescent marijuana use.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2005/05//
VL - 78
IS - 2
SP - 195
EP - 204
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Wright, Douglas, DHHS/SAMHSA/OAS, Room 7-1019, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2005-05204-011. PMID: 15845323 Partial author list: First Author & Affiliation: Wright, Douglas; DHHS/SAMHSA/OAS, Rockville, MD, US. Release Date: 20050606. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Drug Abuse; Marijuana Usage; Models. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: May, 2005.
AB - Multilevel modeling techniques have become a useful tool that enables substance abuse researchers to more accurately identify the contribution of multiple levels of influence on drug-related attitudes and behaviors. However, it is difficult to determine the relative importance of the different hierarchical levels because, in the case of dichotomous outcomes, the variance components estimation involves calculations using a log-odds metric at the lowest level of estimation. We present methods introduced by Goldstein and Rasbash [Goldstein, H., Rasbash, J., 1996. Improved approximations for multilevel models with binary responses. J. Roy. Stat. Soc. A 159,505-513.] to convert the variance components from the log-odds to the probability metric. This method provides a more logical and interpretable way to examine variation for nonlinear outcomes, which tend to be heavily utilized in substance use research. Using data from the National Household Survey on Drug Abuse [Substance Abuse and Mental Health Services Administration (SAMHSA), 2001. 1999 National Household Survey on Drug Abuse. Data Collection Final Report. Office of Applied Studies (OAS), Rockville, MD. Available at http://www.samhsa.gov/oas/nhsda/1999/Collect/toc.htm. Accessed on July 1, 2003.], we partition variation among individual, household, and neighborhood levels for the binary outcome of past year marijuana use to illustrate this approach. We also conduct a stability analysis to examine the robustness across different estimation procedures commonly available in commercial multilevel software packages. Finally, we partition the variance components using a conventional continuously distributed outcome and compare the relative magnitudes across binary and continuous outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent marijuana use
KW - substance abuse
KW - multilevel modeling
KW - 2005
KW - Adolescent Attitudes
KW - Drug Abuse
KW - Marijuana Usage
KW - Models
KW - 2005
DO - 10.1016/j.drugalcdep.2004.11.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05204-011&site=ehost-live&scope=site
UR - dwright@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-05201-012
AN - 2005-05201-012
AU - Ducatman, Alan M.
AU - Vanderploeg, James M.
AU - Johnson, Mark
AU - Rubin, Judith
AU - Harber, Philip
AU - Sokas, Rosemary
AU - Harmon, Robert G.
AU - Rumm, Peter
AU - Nilson, Elizabeth
AU - Batalden, Paul
AU - Merchant, Glenn
AU - Krauss, Margot
AU - Goldberg, Robert L.
AU - Valdez, Michael
AU - Dismuke, S. Edwards
AU - Wagner, Gregory R.
AU - Leniek, Karyn
AU - Rosenthal, Jill
T1 - Residency Training in Preventive Medicine: Challenges and Opportunities.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2005/05//
VL - 28
IS - 4
SP - 403
EP - 412
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Ducatman, Alan M., Department of Community Medicine, School of Medicine, West Virginia University, P.O. Box 9190, Morgantown, WV, US, 26506
N1 - Accession Number: 2005-05201-012. PMID: 15831349 Partial author list: First Author & Affiliation: Ducatman, Alan M.; Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV, US. Release Date: 20050822. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Medical Residency; Preventive Medicine. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 10. Issue Publication Date: May, 2005.
AB - The goal of this paper is to stimulate a specialty-wide conversation to develop a consensus for an improved model for the future of specialty training in preventive medicine. While other specialties are also heavily invested in evidence-based clinical prevention, preventive medicine is unique because its constant, central focus is on population health. Preventive medicine is in a position to work closely with other specialties because of its strength in clinical health systems, population (health) outcomes, and public health. Preventive medicine training must prepare residents to perform within a specialty-dominated and evidence-based healthcare structure. Preventive medicine residency programs have been closing, especially programs facing funding difficulties due, in part, to reductions of federal funding and decisions to favor larger programs in the federal funding formula. Planning should preserve and enhance what is excellent rather than react to perceptions of crisis. The value added by preventive medicine training should be clarified. Preventive medicine, defined by healthcare needs of populations and characterized by population-based intellectual processes, is poorly understood by the public and even by medical colleagues. Attracting trainees who are interested in clinical care, clinical prevention, and population skills represents the most significant challenge to this vision of improved training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventive medicine
KW - residency training
KW - evidence based clinical prevention
KW - 2005
KW - Evidence Based Practice
KW - Medical Residency
KW - Preventive Medicine
KW - 2005
DO - 10.1016/j.amepre.2005.01.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05201-012&site=ehost-live&scope=site
UR - aducatman@hsc.wvu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07355-002
AN - 2005-07355-002
AU - Slikker, William Jr.
AU - Acuff, Karen
AU - Boyes, William K.
AU - Chelonis, John
AU - Crofton, Kevin M.
AU - Dearlove, George E.
AU - Li, Abby
AU - Moser, Virginia C.
AU - Newland, Chris
AU - Rossi, John
AU - Schantz, Susan
AU - Sette, William
AU - Sheets, Larry
AU - Stanton, Mark
AU - Tyl, Shelley
AU - Sobotka, Thomas J.
T1 - Behavioral test methods workshop.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2005/05//May-Jun, 2005
VL - 27
IS - 3
SP - 417
EP - 427
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Slikker, William Jr., National Center for Toxicological Research/FDA, Division of Neurotoxicology, 3900 NCTR Rd, Jefferson, AR, US, 72079
N1 - Accession Number: 2005-07355-002. PMID: 15939202 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Slikker, William Jr.; National Center for Toxicological Research/FDA, Division of Neurotoxicology, Jefferson, US. Release Date: 20051011. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Behavioral Assessment; Experimental Design; Nervous System; Neurotoxicity. Minor Descriptor: Chemicals. Classification: Personality Scales & Inventories (2223); Personality Traits & Processes (3120). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: May-Jun, 2005.
AB - A one and a half day workshop on behavioral testing was conducted in order to discuss experimental procedures and practices that may help enhance the utility of behavioral data as a reliable index of neurotoxicity and in the safety evaluation of chemical substances. The workshop was open to participation by all sectors of the neuroscience community including academia, government, testing laboratories, and industry. The level of confidence with which changes in behavior can reliably signal adverse effects on the nervous system depends, in part, on the scientific quality of the data generated. With an emphasis on education and problem solving, the workshop focused on the practical aspects and scientific rationale underlying valid and high quality testing. In behavioral testing, there are numerous experimental factors that may impact on the quality of data. These include such elements as experimental design, selection of test methods, the care and precision in the conduct of behavioral testing, procedures to minimize bias and potential confounds, appropriateness of statistical analyses, and data interpretation. In plenary session investigators experienced in behavioral testing discussed the significance of these various experimental factors to data quality, outlined problematic issues, and presented a synopsis of approaches for addressing each of the factors as outlined in a draft of a primer developed by the Interagency Committee on Neurotoxicology (ICON). During the remainder of the workshop, open discussions in small breakout groups were used to address the problematic issues identified by the plenary speakers and explore alternative approaches for dealing with them. Finally, all workshop participants were reconvened in plenary session for summation of breakout group discussions and final recommendations. Information from the workshop was used to form the basis of this manuscript and will be used to help finalize a behavioral test methods primer being drafted by the ICON. The overall conclusions from the workshop were that consensus can be reached on the fundamentals of behavioral assessment, and that aspects of behavioral assessment including experimental design, test method selection, training, validation, control of confounds, data variability, data analysis, and data interpretation need to be carefully considered in the planning and conduct of behavioral safety assessments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral testing
KW - experimental design
KW - neurotoxicity
KW - workshop
KW - nervous system
KW - chemical substances
KW - 2005
KW - Behavioral Assessment
KW - Experimental Design
KW - Nervous System
KW - Neurotoxicity
KW - Chemicals
KW - 2005
DO - 10.1016/j.ntt.2005.02.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07355-002&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1749-9971
UR -
UR - wslikker@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06980-004
AN - 2005-06980-004
AU - Power, A. Kathryn
T1 - Achieving the Promise through Workforce Transformation: A View from the Center for Mental Health Services.
JF - Administration and Policy in Mental Health
JO - Administration and Policy in Mental Health
JA - Adm Policy Ment Health
Y1 - 2005/05//May-Jul, 2005
VL - 32
IS - 5-6
SP - 489
EP - 495
CY - Germany
PB - Springer
SN - 0894-587X
AD - Power, A. Kathryn, Center for Mental Health Services, 1 Choke Cherry Road, Room 6-1057, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06980-004. PMID: 16082792 Other Journal Title: Administration and Policy in Mental Health and Mental Health Services Research; Administration in Mental Health. Partial author list: First Author & Affiliation: Power, A. Kathryn; Center for Mental Health Services in the Substance Abuse, Mental Health Services Administration, Rockville, MD, US. Release Date: 20050705. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Psychology; Mental Health Services; Health Personnel; Health Care Administration. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: May-Jul, 2005.
AB - The Annapolis Coalition was formed when the American College of Mental Health Administration and the Academic Behavioral Health Consortium saw a common problem and united to push for a solution. The problem was that many people involved in behavioral health care were not being taught the skills they needed to practice safely or effectively. As a result, we were and continue to fail to meet our nation's current mental health needs, and unless drastic changes are made, we will be incapable of meeting future needs. The solution proposed by the Annapolis Coalition was a national strategy for workforce development that reflects and supports the transformation of our mental health care system. The inclusion of consumers and their families highlights another critical issue in workforce development. Consumers and their families are too seldom educated, empowered, or encouraged about their essential role in making health care decisions. Transformation of our mental health care system is an extremely powerful concept. It calls for profound change, an upheaval and reorganization of what we know, what we do, and how we go about doing it. Our National Strategy for Workforce Development will be our battle plan. Workforce development is the tool that will better prepare a million providers nationwide to transform an ineffective system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workforce transformation
KW - Annapolis Coalition
KW - Center for Mental Health Services
KW - behavioral health care
KW - 2005
KW - Health Care Psychology
KW - Mental Health Services
KW - Health Personnel
KW - Health Care Administration
KW - 2005
DO - 10.1007/s10488-005-3260-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06980-004&site=ehost-live&scope=site
UR - kathryn.power@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04687-005
AN - 2005-04687-005
AU - Cook, Judith A.
AU - Leff, H. Stephen
AU - Blyler, Crystal R.
AU - Gold, Paul B.
AU - Goldberg, Richard W.
AU - Mueser, Kim T.
AU - Toprac, Marcia G.
AU - McFarlane, William R.
AU - Shafer, Michael S.
AU - Blankertz, Laura E.
AU - Dudek, Ken
AU - Razzano, Lisa A.
AU - Grey, Dennis D.
AU - Burke-Miller, Jane
T1 - Results of a Multisite Randomized Trial of Supported Employment Interventions for Individuals With Severe Mental Illness.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 2005/05//
VL - 62
IS - 5
SP - 505
EP - 512
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
AD - Cook, Judith A., Department of Psychiatry, University of Illinois at Chicago, 104 S Michigan Ave, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2005-04687-005. PMID: 15867103 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Cook, Judith A.; Department of Psychiatry, University of Illinois, Chicago, IL, US. Release Date: 20050516. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Mental Disorders; Supported Employment; Vocational Rehabilitation. Classification: Rehabilitation (3380). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Positive and Negative Syndrome Scale DOI: 10.1037/t05056-000; Structured Clinical Interview for DSM-IV Axis I Disorders: Clinician Version. Methodology: Empirical Study; Followup Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 2005.
AB - National probability surveys indicate that most individuals with schizophrenia and other severe mental illnesses are not employed. This multisite study tested the effectiveness of supported employment (SE) models combining clinical and vocational rehabilitation services to establish competitive employment. We randomly assigned 1273 outpatients with severe mental illness from 7 states in the United States to an experimental SE program or to a comparison or a services-as-usual condition, with follow-up for 24 months. Participants were interviewed semiannually, paid employment was tracked weekly, and vocational and clinical services were measured monthly. Mixed-effects random regression analysis was used to predict the likelihood of competitive employment, working 40 or more hours in a given month, and monthly earnings. Cumulative results during 24 months show that experimental group participants (359/648 [55%]) were more likely than those in the comparison programs (210/625 [34%]) to achieve competitive employment (X²=61.17; P<.001). Similarly, patients in experimental group programs (330/648 [51%]) were more likely than those in comparison programs (245/625 [39%]) to work 40 or more hours in a given month (X²=17.66; P<.001). Finally, participants in experimental group programs had significantly higher monthly earnings than those in the comparison programs had significantly higher monthly earnings than those in the comparison programs (mean,$122/mo [n=639] vs $99/mo [n=622]); t₁₂₅₉=-2.04; P<.05). In the multivariate longitudinal analysis, experimental condition subjects were more likely than comparison group subjects to be competitively employed, work 40 or more hours in a given month, and have higher earnings, despite controlling for demographic, clinical, work history, disability beneficiary status, and study site confounders. Moreover, the advantage of experimental over comparison group participants increased during the 24-month study period. In conclusion the SE models tailored by integrating clinical and vocational services were more effective than services as usual or unenhanced services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment interventions
KW - severe mental illness
KW - supported employment models
KW - clinical and vocational rehabilitation
KW - 2005
KW - Employment Status
KW - Mental Disorders
KW - Supported Employment
KW - Vocational Rehabilitation
KW - 2005
DO - 10.1001/archpsyc.62.5.505
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04687-005&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-04588-011
AN - 2005-04588-011
AU - Nguyen, Hong Nga
AU - Lee, Sun Young
AU - Hwang, Dae Youn
AU - Kim, Yong Kyu
AU - Yuk, Dong Yeon
AU - Lee, Jun Seup
AU - Hong, Jin Tae
T1 - Decrease in NF-κB, AP-1 and SP-1 activities in neuronal cells expressing presenilin 2.
JF - NeuroReport: For Rapid Communication of Neuroscience Research
JO - NeuroReport: For Rapid Communication of Neuroscience Research
JA - Neuroreport
Y1 - 2005/05//
VL - 16
IS - 7
SP - 731
EP - 735
CY - US
PB - Lippincott Williams & Wilkins
SN - 0959-4965
SN - 1473-558X
AD - Hong, Jin Tae, College of Pharmacy, Chungbuk National University, 12, Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk, Korea, 361-763
N1 - Accession Number: 2005-04588-011. PMID: 15858415 Other Journal Title: Neuroreport: An International Journal for the Rapid Communication of Research in Neuroscience. Partial author list: First Author & Affiliation: Nguyen, Hong Nga; College of Pharmacy, Chungbuk National University, Chungbuk, Korea. Release Date: 20050531. Correction Date: 20090831. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cells (Biology); Genes; Neurons. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Location: Korea. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: May, 2005.
AB - Decreases in activities of the NF-κB, AP-1 and SP-1 transcription factors, which could act as antiapoptotic factors, in the presenilin 2 transfected PC12 cells, either in nontreatment conditions or under apoptotic stimulation, were found in this study. Similar results were also found in mice brain cells carrying presenilin 2, especially in the mutant gene expressed ones. These findings suggested that presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - transcription factors
KW - neuronal cells
KW - presenilin genes
KW - mice brain cells
KW - 2005
KW - Cells (Biology)
KW - Genes
KW - Neurons
KW - 2005
DO - 10.1097/00001756-200505120-00015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-04588-011&site=ehost-live&scope=site
UR - jinthong@chungbuk.ac.kr
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-05467-001
AN - 2005-05467-001
AU - Moses-Kolko, Eydie L.
AU - Bogen, Debra
AU - Perel, James
AU - Bregar, Amy
AU - Uhl, Kathleen
AU - Levin, Bob
AU - Wisner, Katherine L.
T1 - Neonatal Signs After Late In Utero Exposure to Serotonin Reuptake Inhibitors: Literature Review and Implications for Clinical Applications.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2005/05//
VL - 293
IS - 19
SP - 2372
EP - 2383
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
AD - Moses-Kolko, Eydie L., Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O'Hara St, Pittsburgh, PA, US, 15213
N1 - Accession Number: 2005-05467-001. PMID: 15900008 Partial author list: First Author & Affiliation: Moses-Kolko, Eydie L.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, US. Release Date: 20050613. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Neonatal Development; Neonatal Disorders; Prenatal Exposure; Serotonin Reuptake Inhibitors; Side Effects (Drug). Minor Descriptor: Neonatal Period; Norepinephrine; Pregnancy; Serotonin Norepinephrine Reuptake Inhibitors; Syndromes; Reuptake. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120). Methodology: Literature Review. References Available: Y. Page Count: 12. Issue Publication Date: May, 2005.
AB - Context A neonatal behavioral syndrome linked to in utero serotonin reuptake inhibitor (SRI) exposure during the last trimester of pregnancy has been identified. The US Food and Drug Administration (FDA) and drug manufacturers have recently agreed to a class labeling change for SRIs, which include selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), to include information about potential adverse events in neonates exposed in utero. Integration of data about the neonatal behavioral syndrome into the management of pregnancy in women who take SRIs is a current challenge for physicians. Objectives To review evidence regarding the SRI-related neonatal syndrome and to help clinicians guide their patients in a risk-benefit decision-making process. Data Sources We searched MEDLINE (1966-February 2005) and PsycINFO (1974- February 2005). All articles related to neonatal signs after in utero SRI exposure were acquired, as well as unpublished data on this topic from the FDA advisory committee meeting of June 2004. References cited in case reports and studies were reviewed. Foreign-language literature was included and translated to English. Study Selection and Data Extraction Studies were included if they had clearly identified maternal SRI exposure for a minimum of the final trimester of pregnancy through delivery and assessed neonatal outcomes. We identified 13 case reports describing a total of 18 cases. Nine cohort studies met criteria. When not included in the published article, relative risks and 95% confidence intervals (CIs) were computed from raw data and summary risk ratios and 95% CIs were determined with Mantel-Haenszel estimates. Data Synthesis Compared with early gestational SRI exposure or no exposure, late SRI exposure carries an overall risk ratio of 3.0 (95% CI, 2.0-4.4) for a neonatal behavioral syndrome. The most SRI-related neonatal case reports involved fluoxetine and paroxetine exposures. Neonates primarily display central nervous system, motor, respiratory, and gastrointestinal signs that are usually mild and disappear by 2 weeks of age. Medical management has consisted primarily of supportive care in special care nurseries. A severe syndrome that consists of seizures, dehydration, excessive weight loss, hyperpyrexia, or intubation is rare in term infants (1/313 quantifiable cases). There have been no reported neonatal deaths attributable to neonatal SRI exposure. Conclusions Available evidence indicates that in utero exposure to SRIs during the last trimester through delivery may result in a self-limited neonatal behavioral syndrome that can be managed with supportive care. The risks and benefits of discontinuing an SRI during pregnancy need to be carefully weighed for each individual patient. Development and validation of assessment methods and clinical management strategies are critical to advancing this research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neonatal signs
KW - in-utero exposure
KW - selective serotonin reuptake inhibitors
KW - pregnancy
KW - serotonin & norepinephrine reuptake inhibitors
KW - neonatal behavioral syndrome
KW - 2005
KW - Neonatal Development
KW - Neonatal Disorders
KW - Prenatal Exposure
KW - Serotonin Reuptake Inhibitors
KW - Side Effects (Drug)
KW - Neonatal Period
KW - Norepinephrine
KW - Pregnancy
KW - Serotonin Norepinephrine Reuptake Inhibitors
KW - Syndromes
KW - Reuptake
KW - 2005
DO - 10.1001/jama.293.19.2372
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05467-001&site=ehost-live&scope=site
UR - mosesel@upmc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Improving Health Literacy: Preventing Obesity with Education
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2005/05/02/May2005 Supplement 1
VL - 105
M3 - Editorial
SP - 9
EP - 10
SN - 00028223
N1 - Accession Number: 19648351; Carmona, Richard H. 1; Affiliation: 1: United States Surgeon General, US Department of Health and Human Services; Source Info: May2005 Supplement 1, Vol. 105, p9; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.jada.2005.03.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19648351&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei, Nan
AU - Heflich, Robert H.
AU - Moore, Martha M.
AU - Chen, Tao
T1 - Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2005/05/02/
VL - 572
IS - 1/2
M3 - Article
SP - 14
EP - 26
SN - 00275107
AB - Abstract: The incidence of childhood cancer is increasing and recent evidence suggests an association between childhood cancer and environmental exposure to genotoxins. In the present study, the Big Blue transgenic mouse model was used to determine whether specific periods in early life represent windows of vulnerability to mutation induction by genotoxins in mouse liver. Groups of mice were treated with single doses of 120mg N-ethyl-N-nitrosourea (ENU)/kg body weight or the vehicle either transplacentally to the 18-day-old fetus or at postnatal days (PNDs) 1, 8, 15, 42 or 126; the animals were sacrificed 6 weeks after their treatment. The cII mutation assay was performed to determine the mutant frequencies (MFs) in the livers of the mice. Liver cII MFs for both sexes were dependent on the age at which the animals were treated. Perinatal treatment with ENU (either transplacental treatment to the 18-day-old fetus or i.p. injection at PND 1) induced relatively high MFs. However, ENU treatment at PNDs 8 and 15 resulted in the highest mutation induction. The lowest mutation induction occurred in those animals treated as adults (PND 126). For instance, the cII MF for the PND 8 female group was 646×10−6 while the MF for female adults was only 145×10−6, a more than 4-fold difference. Molecular analysis of the mutants found that A:T→T:A transversions and A:T→G:C transitions characterized the pattern of mutations induced by ENU in both the neonate and adult mice, while the predominate type of mutation in the controls was G:C→A:T. The results indicate that mouse liver is most sensitive to ENU-induced mutation during infancy. This period correlates well with the age-dependent sensitivity to carcinogenicity in mouse liver, suggesting that mutation is an important rate-limiting factor for age-related carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSGENIC mice
KW - TRANSGENIC animals
KW - NITROSOUREAS
KW - ALKYLATING agents
KW - Age
KW - dimethylsulfoxide ( DMSO )
KW - Ethylnitrosourea
KW - Mutagenicity
KW - mutant frequency ( MF )
KW - N-ethyl-N-nitrosourea ( ENU )
KW - Neonate
KW - postnatal days ( PNDs )
KW - Sensitivity
KW - Transgenic mice
N1 - Accession Number: 17548140; Mei, Nan 1 Heflich, Robert H. 1 Moore, Martha M. 1 Chen, Tao; Email Address: tchen@nctr.fda.gov; Affiliation: 1: aDivision of Genetic and Reproductive Toxicology, National Center for Toxicological Research, HFT-130, NCTR/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: May2005, Vol. 572 Issue 1/2, p14; Subject Term: TRANSGENIC mice; Subject Term: TRANSGENIC animals; Subject Term: NITROSOUREAS; Subject Term: ALKYLATING agents; Author-Supplied Keyword: Age; Author-Supplied Keyword: dimethylsulfoxide ( DMSO ); Author-Supplied Keyword: Ethylnitrosourea; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: mutant frequency ( MF ); Author-Supplied Keyword: N-ethyl-N-nitrosourea ( ENU ); Author-Supplied Keyword: Neonate; Author-Supplied Keyword: postnatal days ( PNDs ); Author-Supplied Keyword: Sensitivity; Author-Supplied Keyword: Transgenic mice; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2004.11.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17548140&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dalloul, Rami A.
AU - Lillehoj, Hyun S.
AU - Klinman, Dennis M.
AU - Ding, Xicheng
AU - Min, Wongi
AU - Heckert, Robert A.
AU - Lillehoj, Erik P.
T1 - In ovo administration of CpG oligodeoxynucleotides and the recombinant microneme protein MIC2 protects against Eimeria infections
JO - Vaccine
JF - Vaccine
Y1 - 2005/05/02/
VL - 23
IS - 24
M3 - Article
SP - 3108
EP - 3113
SN - 0264410X
AB - Abstract: We have previously demonstrated that short oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) exert a positive effect on weight loss and oocyst shedding associated with Eimeria infection when injected in vivo. The present work investigated the effects of in ovo vaccination with CpG ODNs and an Eimeria recombinant microneme protein (MIC2), alone or in combination, on susceptibility to coccidiosis. In ovo injection of CpG ODNs alone enhanced resistance to experimental Eimeria acervulina infection as best exemplified by reduced oocyst shedding. Two CpG ODNs reduced the oocyst load, but did not affect weight gain. When co-administered with the recombinant microneme protein, both ODNs reduced oocyst shedding; however, only ODN D19 plus MIC2 consistently improved weight gain. Vaccinating with ODN 2006 or MIC2 protein curtailed oocyst shedding but did not enhance weight gain in Eimeria tenella-infected birds. Co-administration of CpG ODN and MIC2 did not have an additive effect in reducing the oocyst output; however, it resulted in the highest and lowest Ab response before and after Eimeria tenella infection, respectively. Collectively, CpG ODNs administered in ovo demonstrated immunoenhancing and adjuvant effects following Eimeria infections. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Protozoan diseases
KW - Vaccination
KW - Eimeria
KW - Immunological adjuvants
KW - antibody (Ab)
KW - CpG
KW - days post infection (dpi)
KW - Eimeria acervulina (EA)
KW - Eimeria tenella (ET)
KW - In ovo vaccination
KW - Oligodeoxynucleotide
KW - oligodeoxynucleotide (ODN)
KW - phosphate-buffered saline (PBS)
N1 - Accession Number: 16941265; Dalloul, Rami A. 1; Lillehoj, Hyun S. 1; Email Address: hlilleho@anri.barc.usda.gov; Klinman, Dennis M. 2; Ding, Xicheng 1; Min, Wongi 1,3; Heckert, Robert A. 1; Lillehoj, Erik P. 4; Affiliations: 1: Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, BARC-East, Building 1040, ARS, USDA, Beltsville, MD 20705, USA; 2: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; 3: Department of Animal Science, Sunchon National University, 315 Maegok-Dong, Suncheon, Chonnam 540-742, Korea; 4: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA; Issue Info: May2005, Vol. 23 Issue 24, p3108; Thesaurus Term: Protozoan diseases; Thesaurus Term: Vaccination; Thesaurus Term: Eimeria; Subject Term: Immunological adjuvants; Author-Supplied Keyword: antibody (Ab); Author-Supplied Keyword: CpG; Author-Supplied Keyword: days post infection (dpi); Author-Supplied Keyword: Eimeria acervulina (EA); Author-Supplied Keyword: Eimeria tenella (ET); Author-Supplied Keyword: In ovo vaccination; Author-Supplied Keyword: Oligodeoxynucleotide; Author-Supplied Keyword: oligodeoxynucleotide (ODN); Author-Supplied Keyword: phosphate-buffered saline (PBS); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.01.073
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=16941265&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106485769
T1 - Decomposing the total variation in a nested random effects model of neighborhood, household, and individual components when the dependent variable is dichotomous: implications for adolescent marijuana use.
AU - Wright D
AU - Bobashev GV
AU - Novak SP
Y1 - 2005/05/09/
N1 - Accession Number: 106485769. Language: English. Entry Date: 20050715. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7513587.
KW - Cannabis
KW - Communities -- United States
KW - Substance Abuse -- In Adolescence -- United States
KW - Adolescence
KW - Scales
KW - Survey Research
KW - United States
KW - Human
SP - 195
EP - 204
JO - Drug & Alcohol Dependence
JF - Drug & Alcohol Dependence
JA - DRUG ALCOHOL DEPENDENCE
VL - 78
IS - 2
PB - Elsevier Science
AB - Multilevel modeling techniques have become a useful tool that enables substance abuse researchers to more accurately identify the contribution of multiple levels of influence on drug-related attitudes and behaviors. However, it is difficult to determine the relative importance of the different hierarchical levels because, in the case of dichotomous outcomes, the variance components estimation involves calculations using a log-odds metric at the lowest level of estimation. We present methods introduced by Goldstein and Rasbash [Goldstein, H., Rasbash, J., 1996. Improved approximations for multilevel models with binary responses. J. Roy. Stat. Soc. A 159, 505-513.] to convert the variance components from the log-odds to the probability metric. This method provides a more logical and interpretable way to examine variation for nonlinear outcomes, which tend to be heavily utilized in substance use research. Using data from the National Household Survey on Drug Abuse [Substance Abuse and Mental Health Services Administration (SAMHSA), 2001. 1999 National Household Survey on Drug Abuse. Data Collection Final Report. Office of Applied Studies (OAS), Rockville, MD. Available at . Accessed on July 1, 2003.], we partition variation among individual, household, and neighborhood levels for the binary outcome of past year marijuana use to illustrate this approach. We also conduct a stability analysis to examine the robustness across different estimation procedures commonly available in commercial multilevel software packages. Finally, we partition the variance components using a conventional continuously distributed outcome and compare the relative magnitudes across binary and continuous outcomes.
SN - 0376-8716
AD - DHHS/SAMHSA/OAS, Room 7-1019, 1 Choke Cherry Road, Rockville, MD 20857; dwright@samhsa.gov
U2 - PMID: 15845323.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106485769&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carson, Mary M.
AU - Spady, Donald W.
AU - Beeler, Judith A.
AU - Krezolek, Margaret P.
AU - Audet, Susette
AU - Pabst, Henry F.
T1 - Follow-up of infants given measles vaccine at 6 months of age: antibody and CMI responses to MMRII® at 15 months of age and antibody levels at 27 months of age
JO - Vaccine
JF - Vaccine
Y1 - 2005/05/09/
VL - 23
IS - 25
M3 - Article
SP - 3247
EP - 3255
SN - 0264410X
AB - Abstract: The worldwide elimination of measles is an important target. In developed countries, to control measles outbreaks, immunization from 6 months of age is recommended. In this study, infants (n=290) who were (1) born to mothers with natural immunity or to vaccinated mothers and (2) previously immunized with Connaught (CLL) or AIK-C measles vaccine at 6 months of age, were evaluated for measles immunity before and after measles–mumps–rubella (MMRII®) at 15 months of age. Eight weeks after MMRII®, 98.9% of infants were seropositive by enzyme immunoassay (EIA) and 70% demonstrated measles specific cellular immunity by blast transformation (BT) of lymphocytes. At 27 months of age, 98.4% of infants had protective antibody levels by plaque reduction neutralization (PRN) test. These results suggest that AIK-C and CLL vaccines elicit durable protective immunity in young infants when used in early immunization programs. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Measles
KW - Immunization of children
KW - Leucocytes
KW - Measles vaccines
KW - Vaccination regime
N1 - Accession Number: 16941247; Carson, Mary M. 1; Email Address: mcarson@cha.ab.ca; Spady, Donald W. 1; Beeler, Judith A. 2; Krezolek, Margaret P. 1; Audet, Susette 2; Pabst, Henry F. 1; Affiliations: 1: Department of Pediatrics, University of Alberta, 2C3 Walter Mackenzie Center, Edmonton, Alta., Canada T6G 2R7; 2: Division of Viral Products, U.S. Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: May2005, Vol. 23 Issue 25, p3247; Thesaurus Term: Immune response; Subject Term: Measles; Subject Term: Immunization of children; Subject Term: Leucocytes; Author-Supplied Keyword: Measles vaccines; Author-Supplied Keyword: Vaccination regime; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.01.092
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buhse, Lucinda
AU - Kolinski, Richard
AU - Westenberger, Benjamin
AU - Wokovich, Anna
AU - Spencer, John
AU - Chen, Chi Wan
AU - Turujman, Saleh
AU - Gautam-Basak, Mamta
AU - Kang, Gil Jong
AU - Kibbe, Arthur
AU - Heintzelman, Brian
AU - Wolfgang, Eric
T1 - Topical drug classification
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2005/05/13/
VL - 295
IS - 1/2
M3 - Article
SP - 101
EP - 112
SN - 03785173
AB - Abstract: Current definitions of lotions, gels, creams and ointments vary depending on literature source, market history or traditional use. This often leads to confusion when deciding which dosage form to prescribe and/or purchase. The existing classification of topical dosage forms needs to be re-examined to ensure that definitions for different dosage forms are based on consistent scientific principles and that dosage forms can be distinguished from one another. The purpose of this study is to obtain a scientifically based, systematic classification of dosage forms for topical drugs. A variety of prescription and over-the-counter topical products currently marketed as lotions, gels, creams, and ointments are evaluated using different techniques including rheology (viscosity and shear rate versus shear stress), loss on drying (LOD), specific gravity, surface tension, thermogravimetric analysis (TGA), water absorption, dilution properties, microscopic evaluation, transmittance of visible light, appearance and composition. Rheology is the most discriminating property separating creams and lotions. Water plus volatiles (as measured by LOD) and composition separate ointments and creams. Composition and thermal behavior separate gels from the other dosage forms. Based on these findings, new definitions and a decision tree are presented to assist in the determination of the appropriate nomenclature for a topical dosage form. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG delivery systems
KW - COSMETICS
KW - SURFACE chemistry
KW - SURFACE tension
KW - Cream
KW - Gel
KW - Lotion
KW - Ointment
KW - Topical drug
N1 - Accession Number: 17674317; Buhse, Lucinda 1; Email Address: buhsel@cder.fda.gov Kolinski, Richard 1 Westenberger, Benjamin 1 Wokovich, Anna 1 Spencer, John 1 Chen, Chi Wan 2 Turujman, Saleh 2 Gautam-Basak, Mamta 2 Kang, Gil Jong 3 Kibbe, Arthur 4 Heintzelman, Brian 4 Wolfgang, Eric 4; Affiliation: 1: United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA 2: US FDA/CDER/OPS/Office of New Drug Chemistry, Rockville, MD, USA 3: US FDA/CDER/OPS/Office of Generic Drugs, Rockville, MD, USA 4: Wilkes University, Wilkes-Barre, PA, USA; Source Info: May2005, Vol. 295 Issue 1/2, p101; Subject Term: DRUG delivery systems; Subject Term: COSMETICS; Subject Term: SURFACE chemistry; Subject Term: SURFACE tension; Author-Supplied Keyword: Cream; Author-Supplied Keyword: Gel; Author-Supplied Keyword: Lotion; Author-Supplied Keyword: Ointment; Author-Supplied Keyword: Topical drug; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ijpharm.2005.01.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sander, Lane C.
AU - Sharpless, Katherine E.
AU - Satterfleld, Mary B.
AU - Lhara, Toshihide
AU - Phinney, Karen W.
AU - Yen, James H.
AU - Wise, Stephen A.
AU - Gay, Martha L
AU - Lam, Joseph W.
AU - McCooeye, Margaret
AU - Gardner, Graeme
AU - Fraser, Catharine
AU - Sturgeon, Ralph
AU - Roman, Mark
T1 - Determination of Ephedrine Alkaloids in Dietary Supplement Standard Reference Materials.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2005/05/15/
VL - 77
IS - 10
M3 - Article
SP - 3101
EP - 3112
SN - 00032700
AB - A suite of five ephedra-containing dietary supplement Standard Reference Materials (SRMs) has been issued by the National Institute of Standards and Technology (NIST) with certified values for ephedrine alkaloids, synephrine, caffeine, and selected toxic trace elements. The materials represent a variety of natural, extracted, and processed sample matrixes that provide different analytical challenges. The constituents have been determined by multiple independent methods with measurements performed by NIST and by three collaborating laboratories. The methods utilized different sample extraction and cleanup steps in addition to different instrumental analytical techniques and approaches to quantification. In addition, food-matrix proximates were determined by National Food Processor Association laboratories for one of the ephedra-containing SRMs. The SRMs are primarily in- tended for method validation and for use as control materials to support the analysis of dietary supplements and related botanical materials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPHEDRA
KW - DIETARY supplements
KW - VITAMINS
KW - BRONCHODILATOR agents
KW - METHYLXANTHINES
KW - CHEMICAL elements
N1 - Accession Number: 17130658; Sander, Lane C. 1; Email Address: lane.sander@nist.gov Sharpless, Katherine E. 1 Satterfleld, Mary B. 1 Lhara, Toshihide 1 Phinney, Karen W. 1 Yen, James H. 1 Wise, Stephen A. 1 Gay, Martha L 2 Lam, Joseph W. 3 McCooeye, Margaret 3 Gardner, Graeme 3 Fraser, Catharine 3 Sturgeon, Ralph 3 Roman, Mark 4; Affiliation: 1: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899. 2: Center for Food Safey and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740. 3: Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R9. 4: ChromaDex, Clearwater, Florida 33760.; Source Info: 5/15/2005, Vol. 77 Issue 10, p3101; Subject Term: EPHEDRA; Subject Term: DIETARY supplements; Subject Term: VITAMINS; Subject Term: BRONCHODILATOR agents; Subject Term: METHYLXANTHINES; Subject Term: CHEMICAL elements; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sutherland, John B.
AU - Cross, E. Lynn
AU - Heinze, Thomas M.
AU - Freeman, James P.
AU - Moody, Joanna D.
T1 - Fungal biotransformation of benzo[f]quinoline, benzo[h]quinoline, and phenanthridine.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2005/05/15/
VL - 67
IS - 3
M3 - Article
SP - 405
EP - 411
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Cultures ofUmbelopsis ramanniana(=Mucor ramannianus) were grown in fluid Sabouraud medium for 3 days, dosed with 0.23 mM benzo[f]quinoline, benzo[h]quinoline, or phenanthridine (benzo[c]quinoline), and incubated for another 18 days. Cultures were extracted and metabolites (66-75% of the UV absorbance) were separated by high-performance liquid chromatography. They were identified by mass spectrometry and nuclear magnetic resonance spectroscopy. Benzo[f]quinoline was metabolized to benzo[f]quinolinetrans-7,8-dihydrodiol, benzo[f]quinolineN-oxide, and 7-hydroxybenzo[f]quinoline, benzo[h]quinoline was metabolized to benzo[h]quinolinetrans-5,6-dihydrodiol, benzo[h]quinolinetrans-7,8-dihydrodiol, and 7-hydroxybenzo[h]quinoline, and phenanthridine was metabolized to phenanthridineN-oxide and phenanthridin-6(5H)-one. At least one of the metabolites produced from each compound was mutagenic and could not be considered detoxified. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biotransformation (Metabolism)
KW - Quinoline
KW - Metabolites
KW - Spectrum analysis
KW - High performance liquid chromatography
N1 - Accession Number: 16865373; Sutherland, John B. 1; Email Address: john.sutherland@fda.hhs.gov; Cross, E. Lynn 1; Heinze, Thomas M. 1; Freeman, James P. 1; Moody, Joanna D. 1; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: May2005, Vol. 67 Issue 3, p405; Thesaurus Term: Biotransformation (Metabolism); Thesaurus Term: Quinoline; Thesaurus Term: Metabolites; Thesaurus Term: Spectrum analysis; Subject Term: High performance liquid chromatography; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s00253-004-1738-8
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Marcus, Kendall A.
AU - Johann-Liang, Rosemary
AU - Powers, John H.
T1 - Ribavirin Trials and Hantavirus--What We Should Not Conclude.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/05/15/
VL - 40
IS - 10
M3 - Letter
SP - 1550
EP - 1551
SN - 10584838
AB - Presents a letter to the editor referencing the article on ribavirin trials and hantavirus, which was published in an earlier issue of the journal "Clinical Infectious Diseases."
KW - Letters to the editor
KW - Clinical Infectious Diseases (Periodical)
N1 - Accession Number: 16793690; Marcus, Kendall A. 1; Email Address: marcusk@cder.fda.gov; Johann-Liang, Rosemary 1; Powers, John H. 2; Affiliations: 1: Division of Antiviral Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; 2: Office of Drug Evaluation IV, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; Issue Info: 5/15/2005, Vol. 40 Issue 10, p1550; Subject Term: Letters to the editor; Reviews & Products: Clinical Infectious Diseases (Periodical); Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Hisada, Michie
AU - Biggar, Robert J.
AU - Hong-Chuan Li
AU - Hanchard, Barrie
T1 - Comments on the Brief Report "Provirus Load in Breast Milk and Risk of Mother-to-Child Transmission of Human T Lymphotropic Virus Type I".
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/05/15/
VL - 191
IS - 10
M3 - Letter
SP - 1781
EP - 1781
SN - 00221899
AB - Presents a response to a letter to the editor about the association between the human T lymphotrophic virus proviral load in breast milk and viral transmission.
KW - LETTERS to the editor
KW - HTLV (Viruses)
N1 - Accession Number: 16782908; Hisada, Michie 1 Biggar, Robert J. 1; Email Address: biggarb@mail.nih.gov Hong-Chuan Li 1 Hanchard, Barrie 2; Affiliation: 1: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland 2: Department of Pathology, University of the West Indies, Kingston, Jamaica; Source Info: 5/15/2005, Vol. 191 Issue 10, p1781; Subject Term: LETTERS to the editor; Subject Term: HTLV (Viruses); Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor, Deborah R.
AU - Puig, Montserrat
AU - Darnell, Miriam E. R.
AU - Mihalik, Kathleen
AU - Feinstone, Stephen M.
T1 - New Antiviral Pathway That Mediates Hepatitis C Virus Replicon Interferon Sensitivity through ADAR1.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/05/15/
VL - 79
IS - 10
M3 - Article
SP - 6291
EP - 6298
SN - 0022538X
AB - While many clinical hepatitis C virus (HCV) infections are resistant to alpha interferon (IFN-α) therapy, subgenomic in vitro self-replicating HCV RNAs (HCV replicons) are characterized by marked IFN-α sensitivity. IFN-α treatment of replicon-containing cells results in a rapid loss of viral RNA via translation inhibition through double-stranded RNA-activated protein kinase (PKR) and also through a new pathway involving RNA editing by an adenosine deaminase that acts on double-stranded RNA (ADAR1). More than 200 genes are induced by IFN-α, and yet only a few are attributed with an antiviral role. We show that inhibition of both PKR and ADAR1 by the addition of adenovirus-associated RNA stimulates replicon expression and reduces the amount of inosine recovered from RNA in replicon cells. Small inhibitory RNA, specific for ADAR1, stimulated the replicon 40-fold, indicating that ADAR1 has a role in limiting replication of the viral RNA. This is the first report of ADAR's involvement in a potent antiviral pathway and its action to specifically eliminate HCV RNA through adenosine to inosine editing. These results may explain successful HCV replicon clearance by IFN-α in vitro and may provide a promising new therapeutic strategy for HCV as well as other viral infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - HEPATITIS viruses
KW - ANTINEOPLASTIC agents
KW - INTERFERON inducers
KW - PROTEIN kinases
KW - ADENOSINE deaminase
N1 - Accession Number: 17051693; Taylor, Deborah R. 1; Email Address: taylord@cber.fda.gov Puig, Montserrat 1 Darnell, Miriam E. R. 1 Mihalik, Kathleen 1 Feinstone, Stephen M. 1; Affiliation: 1: Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: May2005, Vol. 79 Issue 10, p6291; Subject Term: HEPATITIS C virus; Subject Term: HEPATITIS viruses; Subject Term: ANTINEOPLASTIC agents; Subject Term: INTERFERON inducers; Subject Term: PROTEIN kinases; Subject Term: ADENOSINE deaminase; Number of Pages: 8p; Illustrations: 1 Diagram, 23 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.10.6291-6298.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spiridonov, Nikolay A.
AU - Wong, Lily
AU - Zerfas, Patricia M.
AU - Starost, Matthew F.
AU - Pack, Svetlana D.
AU - Paweletz, Cloud P.
AU - Johnson, Gibbes R.
T1 - Identification and Characterization of SSTK, a Serine/Threonine Protein Kinase Essential for Male Fertility.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2005/05/15/
VL - 25
IS - 10
M3 - Article
SP - 4250
EP - 4261
SN - 02707306
AB - Here we describe and characterize a small serine/threonine kinase (SSTK) which consists solely of the N- and C-lobes of a protein kinase catalytic domain. SSTK protein is highly consented among mammals, and no close homologues were found in the genomes of nonmammalian organisms. SSTK specifically interacts with HSP90-1β, HSC7O, and HSP7O proteins, and this association appears to be required for SSTK kinase activity. The SSTK transcript was most abundant in human and mouse testes but was also detected in all human tissues tested. In the mouse testis, SSTK protein was localized to the heads of elongating spermatids. Targeted deletion of the SSTK gene in mice resulted in male sterility due to profound impairment in motility and morphology of spermatozoa. A defect in DNA condensation in SSTK null mutants occurred in elongating spermatids at a step in spermiogenesis coincident with chromatin displacement of histones by transition proteins. SSTK phosphorylated histones Hi, H2A, H2AX, and H3 but not H2B or H4 or transition protein 1 in vitro. These results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility. Abnormal sperm chromatin condensation is common in sterile men, and our results may provide insight into the molecular mechanisms underlying certain human infertility disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERINE proteinases
KW - PROTEIN kinases
KW - HEAT shock proteins
KW - SPERMATOGENESIS
KW - HUMAN fertility
KW - CHROMATIN
N1 - Accession Number: 17174374; Spiridonov, Nikolay A. 1; Email Address: johnsong@cber.fda.gov Wong, Lily 1 Zerfas, Patricia M. 2 Starost, Matthew F. 2 Pack, Svetlana D. 3 Paweletz, Cloud P. 4 Johnson, Gibbes R. 1; Email Address: johnsong@cber.fda.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 208921 2: Division of Veterinary Resources, National Institutes of Health, Bethesda, Maryland 20892 3: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 4: Uniformed Services University of the Health Sciences, Department of Anatomy, Physiology and Genetics, Institute of Molecular Medicine, Bethesda, Maryland 20814; Source Info: May2005, Vol. 25 Issue 10, p4250; Subject Term: SERINE proteinases; Subject Term: PROTEIN kinases; Subject Term: HEAT shock proteins; Subject Term: SPERMATOGENESIS; Subject Term: HUMAN fertility; Subject Term: CHROMATIN; Number of Pages: 12p; Illustrations: 9 Color Photographs, 40 Black and White Photographs, 3 Diagrams, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/MCB.25.10.4250-4261.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walker, Richard I.
T1 - Considerations for development of whole cell bacterial vaccines to prevent diarrheal diseases in children in developing countries
JO - Vaccine
JF - Vaccine
Y1 - 2005/05/16/
VL - 23
IS - 26
M3 - Article
SP - 3369
EP - 3385
SN - 0264410X
AB - Abstract: Enteric pathogens constitute a major pediatric threat in the developing world through their impact on morbidity and mortality, physical and cognitive development and cause and effect relationship with malnutrition. Although many bacterial pathogens can cause diarrheal diseases, a group of less than 10 including Shigella spp., enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae, and possibly, Campylobacter jejuni account for a significant percentage of these diseases in developing countries. Rotavirus is also a major cause of diarrheal diseases. Vaccines against these agents offer a potentially effective control measure against these diseases, but safe, practical, and effective vaccines for many of these agents have yet to be realized. Many vaccine development approaches are under investigation, but the one that is currently most advanced and that has been most widely applied to enteric pathogens is the use of orally administered live or killed whole pathogen preparations. If inactivated, these vaccines will probably be administered as multiple doses with approximately 1010 to 1011 total particles per dose, but they are relatively safe for oral administration. Further, they may not require a buffer for delivery and can be stored in liquid formulations. Fewer doses may be required for some live attenuated pathogen vaccines, but a buffer will most likely be required for oral delivery and the product must be stored in a dried formulation. Also, safety becomes more of a concern with live pathogens depending on the degree of attenuation, host immunocompetence, and the total number and kinds of attenuated pathogens which may be present in a combined agent vaccine. Both live and killed whole pathogen vaccines can be immunogenic and have the possibility to serve as vectors for other antigens. Although many organisms and serotypes are clinically important, by exploiting antigenic cross reactivity and using some pathogen components as vectors for cloned antigens of other pathogens, it could be possible to induce immunity against major enteric pathogens/serotypes with <10 whole pathogen components in a multi-agent vaccine. Safe and effective mucosal adjuvants may in the future be useful in whole pathogen vaccines, but they do not seem to be essential for immunization. Further, dietary supplements such as zinc, mixed routes of delivery and new regimens are under study which may in the future enhance further the effectiveness of the whole pathogen vaccines which now seem realizable in the near term. For this to happen, however, a coordinated and committed effort is necessary now to address the immunologic, regulatory, manufacturing, testing and implementation issues which will be involved in the realization of this important product to benefit children''s health worldwide. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Vaccines
KW - Diarrhea
KW - Pediatrics
KW - Bacterial vaccines
KW - Developing countries
KW - Diarrheal diseases
N1 - Accession Number: 16941283; Walker, Richard I. 1; Email Address: walkerri@cber.fda.gov; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA; Issue Info: May2005, Vol. 23 Issue 26, p3369; Thesaurus Term: Bacterial diseases; Subject Term: Vaccines; Subject Term: Diarrhea; Subject Term: Pediatrics; Author-Supplied Keyword: Bacterial vaccines; Author-Supplied Keyword: Developing countries; Author-Supplied Keyword: Diarrheal diseases; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.vaccine.2004.12.029
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mei Qin
AU - Kang, Julia
AU - Burlin, Thomas V.
AU - Chunhui Jiang
AU - Smith, Carolyn Beebe
T1 - Postadolescent Changes in Regional Cerebral Protein Synthesis: An In Vivo Study in the Fmr1 Null Mouse.
JO - Journal of Neuroscience
JF - Journal of Neuroscience
Y1 - 2005/05/18/
VL - 25
IS - 20
M3 - Article
SP - 5087
EP - 5095
SN - 02706474
AB - Methylation-induced transcriptional silencing of the fragile X mental retardation-1 (Fmr1) gene leads to absence of the gene product, fragile X mental retardation protein (FMRP), and consequently fragile X syndrome (FrX), an X-linked inherited form of mental retardation. Absence of FMRP in Fmr1 null mice imparts some characteristics of the FrX phenotype, but the precise role of FMRP in neuronal function remains unknown. FMRP is an RNA-binding protein that has been shown to suppress translation of certain mRNAs in vitro. We applied the quantitative autoradiographic L-[1-14C]leucine method to the in vivo determination of regional rates of cerebral protein synthesis (rCPS) in adult wild-type (WT) and Fmr1 null mice at 4 and 6 months of age. Our results show a substantial decrease in rCPS in all brain regions examined between the ages of 4 and 6 months in both WT and Fmr1 null mice. Superimposed on the age-dependent decline in rCPS, we demonstrate a regionally selective elevation in rCPS in Fmr1 null mice. Our results suggest that the process of synaptic pruning during young adulthood may be reflected in decreased rCPS. Our findings support the hypothesis that FMRP is a suppressor of translation in brain in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neuroscience is the property of Society for Neuroscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN synthesis
KW - FRAGILE X syndrome
KW - GENETIC transcription
KW - MENTAL disabilities
KW - X chromosome -- Abnormalities
KW - age
KW - FMRP
KW - fragile X
KW - protein synthesis
KW - synaptic plasticity
KW - synaptic pruning
N1 - Accession Number: 17457185; Mei Qin 1 Kang, Julia 1 Burlin, Thomas V. 1 Chunhui Jiang 1 Smith, Carolyn Beebe 1; Email Address: beebec@intra.nimh.nih.gov; Affiliation: 1: Unit on Neuroadaptation and Protein Metabolism, Laboratory of Cerebral Metabolism, National Institute of Mental Health, United States Public Health Service, Department of Health and Human Services, Bethesda, Maryland 20892; Source Info: 5/18/2005, Vol. 25 Issue 20, p5087; Subject Term: PROTEIN synthesis; Subject Term: FRAGILE X syndrome; Subject Term: GENETIC transcription; Subject Term: MENTAL disabilities; Subject Term: X chromosome -- Abnormalities; Author-Supplied Keyword: age; Author-Supplied Keyword: FMRP; Author-Supplied Keyword: fragile X; Author-Supplied Keyword: protein synthesis; Author-Supplied Keyword: synaptic plasticity; Author-Supplied Keyword: synaptic pruning; Number of Pages: 9p; Illustrations: 2 Color Photographs, 1 Diagram, 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1523/JNEUROSCI.0093-05.2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17457185&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Collin R.
AU - Rupp, Heidi S.
AU - Wu, Wen-Hsin
T1 - Complexities in tetracycline analysis—chemistry, matrix extraction, cleanup, and liquid chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2005/05/20/
VL - 1075
IS - 1/2
M3 - Article
SP - 23
EP - 32
SN - 00219673
AB - Abstract: The extraction and cleanup of commonly used tetracyclines (oxytetracycline, tetracycline, chlortetracycline, and doxycycline) from sample matrix, and their subsequent determination via liquid chromatography can be problematic. Many manuscripts report on various challenges encountered when developing a method for tetracycline antibiotics determination. These complexities often result in less than perfect recoveries or chromatograms and are based on the underlying chemistry associated with tetracyclines. This review compiles, compares, and discusses the results and observations found in published methods, while focusing on chemical principles in order to increase the practicing chemist''s understanding of TCs to aid him/her in developing useful analyses. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Extraction (Chemistry)
KW - Liquid chromatography
KW - Anti-infective agents
KW - Antibacterial agents
KW - Biological matrix extraction
KW - Chromatography
KW - Tetracycline antibiotics
N1 - Accession Number: 17826043; Anderson, Collin R.; Email Address: collin.anderson@fda.gov; Rupp, Heidi S. 1; Email Address: heidi.rupp@fda.gov; Wu, Wen-Hsin 1; Email Address: cindy.wu@fda.gov; Affiliations: 1: U.S. Food and Drug Administration, 1 Seafood Products Research Center/Pacific Regional Laboratory Northwest, 22201 23rd Drive SE, Bothell, WA 98021, USA; Issue Info: May2005, Vol. 1075 Issue 1/2, p23; Thesaurus Term: Extraction (Chemistry); Thesaurus Term: Liquid chromatography; Thesaurus Term: Anti-infective agents; Thesaurus Term: Antibacterial agents; Author-Supplied Keyword: Biological matrix extraction; Author-Supplied Keyword: Chromatography; Author-Supplied Keyword: Tetracycline antibiotics; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chroma.2005.04.013
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Chalmers, R. M.
AU - Grinberg, A.
T1 - Significance of Cryptosporidium parvum in horses.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2005/05/21/
VL - 156
IS - 21
M3 - Letter
SP - 688
EP - 688
SN - 00424900
AB - Presents a letter to the editor about the parasite Cryptosporidium parvum as a cause of diarrheal disease in horses.
KW - CRYPTOSPORIDIUM parvum
KW - LETTERS to the editor
N1 - Accession Number: 17522087; Chalmers, R. M. 1 Grinberg, A. 2; Affiliation: 1: Cryptosporidium Reference Unit, National Public Health Service Microbiology Swansea, Singleton Hospital, Swansea, SA2 8QA 2: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand; Source Info: 5/21/2005, Vol. 156 Issue 21, p688; Subject Term: CRYPTOSPORIDIUM parvum; Subject Term: LETTERS to the editor; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, Shaohua
AU - Maurer, John J.
AU - Hubert, Susannah
AU - De Villena, Juan F.
AU - McDermott, Patrick F.
AU - Meng, Jianghong
AU - Ayers, Sherry
AU - English, Linda
AU - White, David G.
T1 - Antimicrobial susceptibility and molecular characterization of avian pathogenic Escherichia coli isolates
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2005/05/23/
VL - 107
IS - 3/4
M3 - Article
SP - 215
EP - 224
SN - 03781135
AB - Abstract: Ninety-five avian pathogenic Escherichia coli (APEC) isolates recovered from diagnosed cases of avian colibacillosis from North Georgia between 1996 and 2000 were serotyped and examined for typical virulence-factors, susceptibility to antimicrobials of human and veterinary significance, and genetic relatedness. Twenty different serotypes were identified, with O78 being the most common (12%). The majority of the avian E. coli isolates (60%), however, were non-typeable with standard O antisera. Eighty-four percent of isolates were PCR positive for the temperature-sensitive hemagglutinin (tsh) gene and 86% positive for the increased serum survival (iss) gene. Multiple antimicrobial-resistant phenotypes (≥3 antimicrobials) were observed in 92% of E. coli isolates, with the majority of isolates displaying resistance to sulfamethoxazole (93%), tetracycline (87%), streptomycin (86%), gentamicin (69%), and nalidixic acid (59%). Fifty-six E. coli isolates displaying resistance to nalidixic acid were co-resistant to difloxacin (57%), enrofloxacin (16%), gatifloxacin (2%), and levofloxacin (2%). DNA sequencing revealed point mutations in gyrA (Ser83-Leu, Asp87-Tyr, Asp87-Gly, Asp87-Ala), gyrB (Glu466-Asp, Asp426-Thr), and parC (Ser80-Ile, Ser80-Arg). No mutations were observed in parE. Twelve of the quinolone-resistant E. coli isolates were tolerant to cyclohexane, a marker for upregulation of the acrAB multi-drug resistance efflux pump. Quinolone-resistant isolates were further genetically characterized via ribotyping. Twenty-two distinct ribogroups were identified, with 61% of isolates clustering into four major ribogroups, indicating that quinolone resistance has emerged among multiple avian pathogenic E. coli serogroups and chromosomal backgrounds. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli diseases
KW - AVIAN influenza
KW - ANTI-infective agents
KW - DNA topoisomerase II
KW - ESCHERICHIA coli
KW - Antibiotic resistance
KW - Avian pathogenic Escherichia coli
KW - DNA gyrase
KW - Efflux
KW - Fluoroquinolones
N1 - Accession Number: 17699941; Zhao, Shaohua 1 Maurer, John J. 2 Hubert, Susannah 1 De Villena, Juan F. 3 McDermott, Patrick F. 1 Meng, Jianghong 3 Ayers, Sherry 1 English, Linda 1 White, David G. 1; Email Address: David.White@fda.gov; Affiliation: 1: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA 2: Poultry Diagnostic Research Center, University of Georgia, Athens, GA, USA 3: Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; Source Info: May2005, Vol. 107 Issue 3/4, p215; Subject Term: ESCHERICHIA coli diseases; Subject Term: AVIAN influenza; Subject Term: ANTI-infective agents; Subject Term: DNA topoisomerase II; Subject Term: ESCHERICHIA coli; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: Avian pathogenic Escherichia coli; Author-Supplied Keyword: DNA gyrase; Author-Supplied Keyword: Efflux; Author-Supplied Keyword: Fluoroquinolones; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vetmic.2005.01.021
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17699941&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rathore, Dharmendar
AU - Nagarkatti, Rana
AU - Jani, Dewal
AU - Chattopadhyay, Rana
AU - De La Vega, Patricia
AU - Kumar, Sanjai
AU - Mccutchan, Thomas F.
T1 - An Immunologically Cryptic Epitope of Plasmodium falciparum Circumsporozoite Protein Facilitates Liver Cell Recognition and Induces Protective Antibodies That Block Liver Cell Invasion.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/05/27/
VL - 280
IS - 21
M3 - Article
SP - 20524
EP - 20529
SN - 00219258
AB - Circumsporozoite, a predominant surface protein, is involved in invasion of liver cells by Plasmodium sporozoites, which leads to malaria. We have previously reported that the amino terminus region (amino acids 27117) of P. falciparum circumsporozoite protein plays a critical role in the invasion of liver cells by the parasite. Here we show that invasion-blocking antibodies are induced by a polypeptide encoding these 91 amino acids, only when it is presented in the absence of the rest of the protein. This suggests that when present in the whole protein, the amino terminus remains immunologically cryptic. A single reactive epitope was identified and mapped to a stretch of 21 amino acids from position 93 to 113. The epitope is configurational in nature, since its recognition was affected by deleting as little as 3 amino acids from either end of the 21-residue peptide. Lysine 104, the only known polymorphic position in the epitope, affected its recognition by the antibodies, and its conversion to leucine in the protein led to a substantial loss of binding activity of the protein to the hepatocytes. This indicated that in the protein, the epitope serves as a binding ligand and facilitates the interaction between sporozoite and hepatic cells. When considered along with the observation that in its native state this motif is immunologically unresponsive, we suggest that hiding functional moieties of the protein from the immune system is an evasion strategy to preserve liver cell binding function and may be of importance in designing anti-sporozoite vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENIC determinants
KW - IMMUNOLOGY
KW - PLASMODIUM falciparum
KW - PROTEINS
KW - LIVER cells
KW - AMINO acids
N1 - Accession Number: 17253887; Rathore, Dharmendar 1,2; Email Address: Rathore@vbi.vt.edu Nagarkatti, Rana 1 Jani, Dewal 1 Chattopadhyay, Rana 1 De La Vega, Patricia 3 Kumar, Sanjai 4 Mccutchan, Thomas F. 2; Email Address: Tmccutchan@niaid.nih.gov; Affiliation: 1: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 2: Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 3: Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 4: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: 5/27/2005, Vol. 280 Issue 21, p20524; Subject Term: ANTIGENIC determinants; Subject Term: IMMUNOLOGY; Subject Term: PLASMODIUM falciparum; Subject Term: PROTEINS; Subject Term: LIVER cells; Subject Term: AMINO acids; Number of Pages: 6p; Illustrations: 2 Color Photographs, 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M414254200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17253887&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Song, Kaimei
AU - Rabin, Ronald L.
AU - Hill, Brenna J.
AU - De Rosa, Stephen C.
AU - Perfetto, Stephen P.
AU - Zhang, Hongwei H.
AU - Foley, John F.
AU - Reiner, Jeffrey S.
AU - Jie Liu
AU - Mattapallil, Joseph J.
AU - Douek, Daniel C.
AU - Roederer, Mario
AU - Farber, Joshua M.
T1 - Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2005/05/31/
VL - 102
IS - 22
M3 - Article
SP - 7916
EP - 7921
SN - 00278424
AB - The pathways for differentiation of human CD4+ T cells into functionally distinct subsets of memory cells in vivo are unknown. The identification of these subsets and pathways has clear implications for the design of vaccines and immune-targeted therapies. Here, we show that populations of apparently naive CD4+ T cells express the chemokine receptors CXCR3 or CCR4 and demonstrate patterns of gene expression and functional responses characteristic of memory cells. The proliferation history and T cell receptor repertoire of these chemokine-receptor' cells suggest that they are very early memory CD4+ T cells that have "rested down" before acquiring the phenotypes described for "central" or "effector" memory T cells. In addition, the chemokine-receptor' "naïve" populations contain Th1 and Th2 cells, respectively, demonstrating that Thl/Th2 differentiation can occur very early in vivo in the absence of markers conventionally associated with memory cells. We localized ligands for CXCR3 and CCR4 to separate foci in T cell zones of tonsil, suggesting that the chemokine-receptor' subsets may be recruited and contribute to segregated, polarized micro- environments within lymphoid organs. Importantly, our data suggest that CD4+ T cells do not differentiate according to a simple schema from naïve → CD45RO+ noneffector/central memory → effector/effector memory cells. Rather, developmental pathways branch early on to yield effector/memory populations that are highly heterogeneous and multifunctional and have the potential to become stable resting cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - VACCINES
KW - CELL receptors
KW - GENE expression
KW - GENOTYPE-environment interaction
KW - PREVENTIVE medicine
KW - chemokines
KW - immunologic memory
KW - Th1/Th2 cells
N1 - Accession Number: 17320117; Song, Kaimei 1 Rabin, Ronald L. 2 Hill, Brenna J. 3 De Rosa, Stephen C. 4 Perfetto, Stephen P. 5 Zhang, Hongwei H. 1 Foley, John F. 1 Reiner, Jeffrey S. 1 Jie Liu 5 Mattapallil, Joseph J. 5 Douek, Daniel C. 3 Roederer, Mario 5 Farber, Joshua M. 1; Email Address: jfarber@niaid.nih.gov.; Affiliation: 1: Inflammation Biology Section, Laboratory of Molecular Immunology 2: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892 3: Section of Human Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 4: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109. 5: Section of ImmunoTechnology, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 5/31/2005, Vol. 102 Issue 22, p7916; Subject Term: T cells; Subject Term: VACCINES; Subject Term: CELL receptors; Subject Term: GENE expression; Subject Term: GENOTYPE-environment interaction; Subject Term: PREVENTIVE medicine; Author-Supplied Keyword: chemokines; Author-Supplied Keyword: immunologic memory; Author-Supplied Keyword: Th1/Th2 cells; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0409720102
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kamath, Arun T.
AU - Fruth, Uli
AU - Brennan, Michael J.
AU - Dobbelaer, Roland
AU - Hubrechts, Peter
AU - Ho, Mei Mei
AU - Mayner, Ronald E.
AU - Thole, Jelle
AU - Walker, K. Barry
AU - Liu, Margaret
AU - Lambert, Paul-Henri
T1 - New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development
JO - Vaccine
JF - Vaccine
Y1 - 2005/05/31/
VL - 23
IS - 29
M3 - Article
SP - 3753
EP - 3761
SN - 0264410X
AB - Abstract: As the disease caused by Mycobacterium tuberculosis continues to be a burden, which the world continues to suffer, there is a concerted effort to find new vaccines to combat this problem. Of the various vaccines strategies, one viable option is the development of live mycobacterial vaccines. A meeting with researchers, regulatory bodies, vaccines developers and manufactures was held to consider the challenges and progress, which has been achieved with live mycobacterial vaccines (either modified BCG or attenuated M. tuberculosis). Discussion led to the production of a consensus document of the proposed entry criteria for Phase I clinical trials of candidate live mycobacterial vaccines. The vaccine must be characterised thoroughly to prove identity and consistency, as clinical trial lots are prepared. In pre-clinical studies, greater protective efficacy as well as improved safety potential relative to BCG should be considered when assessing potential vaccine candidates. A standard way to measure the protective efficacy to facilitate comparison between vaccine candidates was suggested. Additional safety criteria and verification of attenuation must be considered for attenuated M. tuberculosis. Two non-reverting independent mutations are recommended for such vaccines. When entering Phase I trials, enrolment should be based upon an acceptable characterisation of the study population regarding mycobacterium status and exclude HIV+ individuals. BCG could be used as a comparator for blinding during the trials and to properly assess vaccine-specific adverse reactions, while assays are being developed to assess immunogenicity of vaccines. The proposed criteria suggested in this consensus document may facilitate the movement of the most promising vaccine candidates to the clinic and towards control of tuberculosis. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Mycobacterium tuberculosis
KW - Mycobacterial diseases
KW - Preventive medicine
KW - Trials
KW - Vaccines
N1 - Accession Number: 17812303; Kamath, Arun T. 1; Fruth, Uli 2; Brennan, Michael J. 3; Dobbelaer, Roland 4; Hubrechts, Peter 5; Ho, Mei Mei 6; Mayner, Ronald E. 7; Thole, Jelle 8; Walker, K. Barry 9; Liu, Margaret 10; Lambert, Paul-Henri 1; Email Address: Paul.Lambert@medecine.unige.ch; Affiliations: 1: Department of Pathology and Immunology, Center for Vaccinology and Neonatal Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland; 2: Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland; 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; 4: Health, Food Chain Security and Environment, Scientific Institute of Public Health, Brussels, Belgium; 5: Quality Control Department, Statens Serum Institut, Copenhagen, Denmark; 6: Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, UK; 7: Aeras Global TB Vaccine Foundation, Bethesda, MD, USA; 8: Division of Infectious Diseases, Animal Sciences Group, Lelystad, The Netherlands; 9: Division of Immunobiology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, UK; 10: Transgene S.A., Strasbourg, France; Issue Info: May2005, Vol. 23 Issue 29, p3753; Thesaurus Term: Vaccination; Subject Term: Mycobacterium tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Preventive medicine; Author-Supplied Keyword: Trials; Author-Supplied Keyword: Vaccines; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.03.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17812303&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jakab, Ferenc
AU - Péterfai, János
AU - Meleg, Edina
AU - Bányai, Krisztián
AU - Mitchell, Douglas K.
AU - SzŰcs, György
T1 - Comparison of clinical characteristics between astrovirus and rotavirus infections diagnosed in 1997 to 2002 in Hungary.
JO - Acta Paediatrica
JF - Acta Paediatrica
Y1 - 2005/06//
VL - 94
IS - 6
M3 - Article
SP - 667
EP - 671
PB - Wiley-Blackwell
SN - 08035253
AB - Aim: To determine the severity and clinical characteristics of human astrovirus (HAstV) infections among hospitalized children and compare them with children infected by rotavirus. Methods: Retrospective, case-control study of astrovirus-infected and rotavirus-infected children. Astroviruses were detected in stool samples by enzyme immunoassay and/or reverse transcriptase-polymerase chain reaction. All stool samples were tested for rotavirus and bacterial pathogens, and all negative samples were further tested for human astrovirus. Children with astrovirus-positive stool samples and complete clinical data were included in this study. Results: Astrovirus was detected in 29 (1.8%) children, and 63 rotavirus-infected children were included as controls. Astrovirus-infected children had shorter duration of diarrhea than rotavirus-infected children (median 4 and 6?d, respectively; p Conclusion: HAstV-infected children had similar symptoms to those occurring in rotavirus infection. However, astrovirus-infected patients had a significantly shorter duration of diarrhea and vomiting, and they required a shorter hospitalization. On the basis of the clinical data and severity scores, children with rotavirus infection had more severe illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Paediatrica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases
KW - VIRUS diseases
KW - INFECTION in children
KW - JUVENILE diseases
KW - PATHOGENIC microorganisms
KW - ENZYME-linked immunosorbent assay
KW - POLYMERASE chain reaction
KW - Astrovirus
KW - children
KW - clinical symptoms
KW - diarrhea
KW - rotavirus
N1 - Accession Number: 17342894; Jakab, Ferenc 1,2; Email Address: jakabf@baranya.antsz.hu Péterfai, János 3 Meleg, Edina 1,2 Bányai, Krisztián 1 Mitchell, Douglas K. 4 SzŰcs, György 1,2; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 2: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary 3: Department of Pediatrics, Municipal “Szent Lászlo” Hospital for Infectious Diseases, Budapest, Hungary 4: Center for Pediatric Research, Children's Hospital of The King's Daughters, Eastern Virginia Medical School Norfolk, VA, USA; Source Info: Jun2005, Vol. 94 Issue 6, p667; Subject Term: ROTAVIRUS diseases; Subject Term: VIRUS diseases; Subject Term: INFECTION in children; Subject Term: JUVENILE diseases; Subject Term: PATHOGENIC microorganisms; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: Astrovirus; Author-Supplied Keyword: children; Author-Supplied Keyword: clinical symptoms; Author-Supplied Keyword: diarrhea; Author-Supplied Keyword: rotavirus; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/08035250510027697
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17342894&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106504865
T1 - Putting prevention into practice: an evidence-based approach Screening for abdominal aortic aneurism.
AU - Guirguis-Blake J
AU - Wolfe TA
Y1 - 2005/06//6/1/2005
N1 - Accession Number: 106504865. Language: English. Entry Date: 20050826. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Aortic Aneurysm, Abdominal -- Prevention and Control
KW - Health Screening
KW - Aged
KW - Aortic Aneurysm, Abdominal -- Risk Factors
KW - Education, Continuing (Credit)
KW - Male
SP - 2154
EP - 2155
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 71
IS - 11
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Program Director, US Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality,
U2 - PMID: 15952445.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106504865&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nelson, Tanya
T1 - Selecting the right residency program.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2005/06//6/1/2005
VL - 62
IS - 11
M3 - Article
SP - 1138
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Offers advice to pharmacists on choosing the right residency, a postgraduate training program in a defined area of pharmacy practice. Benefits of a residency program; Types of residency program; Availability of a director of general pharmacy practice and specialized residencies from the American Society of Health-System Pharmacists.
KW - PHARMACISTS
KW - PHARMACY
KW - PHARMACOLOGY
KW - OCCUPATIONAL training
KW - UNITED States
N1 - Accession Number: 17133844; Nelson, Tanya 1; Email Address: tannels@iupui.edu; Affiliation: 1: Drug Development Fellow, Drug Information, Division of Drug Information Food and Drug Administration; Source Info: 6/1/2005, Vol. 62 Issue 11, p1138; Subject Term: PHARMACISTS; Subject Term: PHARMACY; Subject Term: PHARMACOLOGY; Subject Term: OCCUPATIONAL training; Subject Term: UNITED States; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roy, S.
AU - Caillouette, J. C.
AU - Faden, J. S.
AU - Roy, T.
T1 - The role of an over-the-counter vaginal pH self-test device package insert: Can subjects Learn what the device is for and how to use it?
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2005/06//
VL - 192
IS - 6
M3 - Article
SP - 1963
EP - 1969
SN - 00029378
AB - Objective: This study was undertaken to determine whether subjects could read and understand the package insert of a vaginal pH self-test device to improve self-diagnostic accuracy. Study design: This study was performed at 8 clinic locations with 206 women of varying ages, ethnicity, and education. A package insert explaining the indications and clinical facts associated with the use of a vaginal pH self-test device was used. A 16-item questionnaire was administered to assess comprehension. Results: The cumulative probability of having 12 or more correct answers of 16 was P = .038, significantly different than by chance alone, representing 200 (97.1%) of subjects in this trial. Conclusion: The package insert for the vaginal pH self-test device was read and understood by subjects. Indeed, they correctly understood the role of vaginal pH as an aid in the diagnosis of vaginal symptoms while improving decisions to use an over-the-counter antifungal medication or to see a health care provider. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VAGINAL diseases
KW - VAGINA -- Abnormalities
KW - VAGINA
KW - FEMALE reproductive organs
KW - OBSTETRICS
KW - GYNECOLOGY
KW - MEDICINE
KW - Antifungal
KW - device
KW - Over-the-counter
KW - Vaginal pH self-test
KW - Vaginitis
N1 - Accession Number: 17473712; Roy, S. 1; Email Address: subirro@usc.edu; Caillouette, J. C. 1; Faden, J. S. 2; Roy, T. 3; Source Information: Jun2005, Vol. 192 Issue 6, p1963; Subject: VAGINAL diseases; Subject: VAGINA -- Abnormalities; Subject: VAGINA; Subject: FEMALE reproductive organs; Subject: OBSTETRICS; Subject: GYNECOLOGY; Subject: MEDICINE; Author-Supplied Keyword: Antifungal; Author-Supplied Keyword: device; Author-Supplied Keyword: Over-the-counter; Author-Supplied Keyword: Vaginal pH self-test; Author-Supplied Keyword: Vaginitis; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ajog.2005.02.056
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Bluhm, Louis
AU - Huang, Junmin
AU - Li, Tingyu
T1 - Recent advances in peptide chiral selectors for electrophoresis and liquid chromatography.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2005/06//
VL - 382
IS - 3
M3 - Article
SP - 592
EP - 598
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - The application of peptides in chiral separations using techniques such as capillary electrophoresis (CE), electrokinetic capillary chromatography (EKC) and liquid chromatography is the focus of this review. Methods for finding peptide selectors using combinatorial library approaches are discussed, as well as recent advances in the use of peptides as general chiral selectors for electrophoresis and liquid chromatography. One example shows the effectiveness of polymeric dipeptide surfactants as general chiral selectors for electrophoresis. Another example shows the versatility of oligoproline chiral stationary phases, exhibiting resolution for a number of racemic analytes comparable to other well-established chiral stationary phases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEPTIDES
KW - CHIRALITY
KW - CAPILLARY electrophoresis
KW - ELECTROKINETICS
KW - LIQUID chromatography
KW - SURFACE active agents
KW - Chiral chromatography
KW - Chiral separation
KW - Chiral stationary phase
KW - Combinatorial library
KW - Electrophoresis
KW - Peptide chiral selector
N1 - Accession Number: 17211493; Bluhm, Louis 1 Huang, Junmin 2 Li, Tingyu 2; Email Address: TL45@ra.msstate.edu; Affiliation: 1: U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA 2: Department of Chemistry, Mississippi State University, Box 9573, MS 39762, USA; Source Info: Jun2005, Vol. 382 Issue 3, p592; Subject Term: PEPTIDES; Subject Term: CHIRALITY; Subject Term: CAPILLARY electrophoresis; Subject Term: ELECTROKINETICS; Subject Term: LIQUID chromatography; Subject Term: SURFACE active agents; Author-Supplied Keyword: Chiral chromatography; Author-Supplied Keyword: Chiral separation; Author-Supplied Keyword: Chiral stationary phase; Author-Supplied Keyword: Combinatorial library; Author-Supplied Keyword: Electrophoresis; Author-Supplied Keyword: Peptide chiral selector; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 7p; Illustrations: 8 Diagrams; Document Type: Article
L3 - 10.1007/s00216-005-3171-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buehler, Paul W.
AU - Boykins, Robert A.
AU - Ylping Jia
AU - Norris, Scott
AU - Freedberg, Darón I.
AU - Alayash, Abdu I.
T1 - Structural and Functional Characterization of Glutaraldehyde-Polymerized Bovine Hemoglobin and Its Isolated Fractions.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2005/06//6/1/2005
VL - 77
IS - 11
M3 - Article
SP - 3466
EP - 3478
SN - 00032700
AB - Glutaraldehyde-polymerized bovine hemoglobin (Poly- HbBv, trade name Oxyglobin), is a non-site-specific modified hemoglobin-based oxygen-carrying solution, developed for use in veterinary medicine. PolyHbBv was fractionated into four distinct tetrameric and multiple polytetrameric forms ranging in molecular mass (87.2-502.3 kDa) using size exclusion chromatography (SEC) and verified by laser light scattering. We evaluated the structural modification occuring in the fractionated mixture of PolyHbBv and assessed the functionality and redox stability of each fraction in relation to the mixture as a whole. Intramolecular cross-linking evaluation as per- formed by MALDI-MS and SEC under dissociating conditions revealed no-site-specific tetramer stabilization within the fractions; Intermolecular cross-linking was highly correlated with lysine and histidine modification as determined by amino acid composition analysis. While native unmodified hemoglobin, HbBv, PolyHbBv, and PolyHbBv fractions (F1-F4) revealed significant methionine oxidation, modification, or both, the critical βMet55 located in the functionally plastic domains (α1 - β1 interface) of HbBv was unaltered. Moreover, neither of the two βCys93 located in the highly plastic α1-β2 interface were modified in PolyHbBv or in F1-F4. Our structural analysis also revealed that the reported loss in sensitivity to chloride in PolyHbBv could not be attributed to direct alteration of chloride ion binding amino acids. Structural modification imparted by glutaraldehyde resulted in nearly identical functional characteristics of PolyHbBv and its fractions with regard to oxygen equilibrium, ligand binding, and autoxidative kinetics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - VETERINARY medicine
KW - GEL permeation chromatography
KW - AMINO acids
KW - BIOCHEMISTRY
KW - LYSINE
N1 - Accession Number: 17319798; Buehler, Paul W. 1 Boykins, Robert A. 1 Ylping Jia 1 Norris, Scott 1 Freedberg, Darón I. 1 Alayash, Abdu I. 1; Email Address: alayash@cberida.gov.; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, and Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892.; Source Info: 6/1/2005, Vol. 77 Issue 11, p3466; Subject Term: HEMOGLOBIN; Subject Term: VETERINARY medicine; Subject Term: GEL permeation chromatography; Subject Term: AMINO acids; Subject Term: BIOCHEMISTRY; Subject Term: LYSINE; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Ward, Elizabeth
AU - Jemal, Ahmedin
AU - Thun, Michael
T1 - Regarding “Increase in Breast Cancer Incidence in Middle-aged Women during the 1990s”
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2005/06//
VL - 15
IS - 6
M3 - Letter
SP - 424
EP - 425
SN - 10472797
N1 - Accession Number: 18028029; Ward, Elizabeth 1 Jemal, Ahmedin 1 Thun, Michael 1; Affiliation: 1: National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA; Source Info: Jun2005, Vol. 15 Issue 6, p424; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.annepidem.2004.09.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeffrey N. Siegel
AU - Bo‐Guang Zhen
T1 - Use of the American College of Rheumatology N (ACR‐N) index of improvement in rheumatoid arthritis: Argument in favorNo official support or endorsement of this article by the FDA is intended or should be inferred. The views presented in this article do not necessarily reflect those of the FDA.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2005/06//
VL - 52
IS - 6
M3 - Article
SP - 1637
EP - 1641
SN - 00043591
N1 - Accession Number: 20686038; Jeffrey N. Siegel 1 Bo‐Guang Zhen 1; Affiliation: 1: Center for Drug Evaluation and Research, FDA, Rockville, Maryland; Source Info: Jun2005, Vol. 52 Issue 6, p1637; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106301389
T1 - Use of the American College of Rheumatology N (ACR-N) index of improvement in rheumatoid arthritis: argument in favor.
AU - Siegel JN
AU - Zhen B
Y1 - 2005/06//
N1 - Accession Number: 106301389. Language: English. Entry Date: 20070615. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0370605.
KW - Antirheumatic Agents -- Therapeutic Use
KW - Arthritis, Rheumatoid -- Drug Therapy
KW - Arthritis, Rheumatoid -- Epidemiology
KW - Health Status Indicators
KW - Clinical Trials
KW - T-Tests
KW - Treatment Outcomes
KW - Human
SP - 1637
EP - 1641
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
JA - ARTHRITIS RHEUM
VL - 52
IS - 6
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
SN - 0004-3591
AD - Center for Drug Evaluation and Research, FDA, Rockville, Maryland 20857, USA. siegelj@cber.fda.gov
U2 - PMID: 15934067.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - Bowyer, John F.
AU - Pabarcus, Michael K.
AU - Heflich, Robert H.
AU - Williams, Lee D.
AU - Doerge, Daniel R.
AU - Arvidsson, Björn
AU - Bergquist, Jonas
AU - Casida, John E.
T1 - Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype
JO - BBA - General Subjects
JF - BBA - General Subjects
Y1 - 2005/06//
VL - 1724
IS - 1/2
M3 - Article
SP - 163
EP - 172
SN - 03044165
AB - Abstract: The gene coding for arylformamidase (Afmid, also known as kynurenine formamidase) was inactivated in mice through the removal of a shared bidirectional promoter region regulating expression of the Afmid and thymidine kinase (Tk) genes. Afmid/Tk -deficient mice are known to develop sclerosis of glomeruli and to have an abnormal immune system. Afmid-catalyzed hydrolysis of N-formyl-kynurenine is a key step in tryptophan metabolism and biosynthesis of kynurenine-derived products including kynurenic acid, quinolinic acid, nicotinamide, NAD, and NADP. A disruption of these pathways is implicated in neurotoxicity and immunotoxicity. In wild-type (WT) mice, Afmid-specific activity (as measured by formyl-kynurenine hydrolysis) was 2-fold higher in the liver than in the kidney. Formyl-kynurenine hydrolysis was reduced by ∼50% in mice heterozygous (HZ) for Afmid/Tk and almost completely eliminated in Afmid/Tk knockout (KO) mice. However, there was 13% residual formyl-kynurenine hydrolysis in the kidney of KO mice, suggesting the existence of a formamidase other than Afmid. Liver and kidney levels of nicotinamide plus NAD/NADP remained the same in WT, HZ and KO mice. Plasma concentrations of formyl-kynurenine, kynurenine, and kynurenic acid were elevated in KO mice (but not HZ mice) relative to WT mice, further suggesting that there must be enzymes other than Afmid (possibly in the kidney) capable of metabolizing formyl-kynurenine into kynurenine. Gradual kidney deterioration and subsequent failure in KO mice is consistent with high levels of tissue-specific Afmid expression in the kidney of WT but not KO mice. On this basis, the most significant function of the kynurenine pathway and Afmid in mice may be in eliminating toxic metabolites and to a lesser extent in providing intermediates for other processes. [Copyright &y& Elsevier]
AB - Copyright of BBA - General Subjects is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRYPTOPHAN
KW - BIOLOGICAL products
KW - BIOCHEMISTRY
KW - ABDOMEN
KW - Arylformamidase
KW - Formyl-kynurenine
KW - Kynurenic acid
KW - Kynurenine
KW - Kynurenine formamidase
KW - Tryptophan
N1 - Accession Number: 17924126; Dobrovolsky, Vasily N. 1; Email Address: vdobrovolsky@nctr.fda.gov Bowyer, John F. 2 Pabarcus, Michael K. 3 Heflich, Robert H. 1 Williams, Lee D. 4 Doerge, Daniel R. 4 Arvidsson, Björn 5 Bergquist, Jonas 5 Casida, John E. 3; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., HFT-120, Jefferson, AR 72079, USA 2: Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, USA 3: Department of Environmental Science, Policy and Management, University of California, Berkeley, CA, USA 4: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA 5: Department of Analytical Chemistry, Institute of Chemistry, Uppsala University, Uppsala, Sweden; Source Info: Jun2005, Vol. 1724 Issue 1/2, p163; Subject Term: TRYPTOPHAN; Subject Term: BIOLOGICAL products; Subject Term: BIOCHEMISTRY; Subject Term: ABDOMEN; Author-Supplied Keyword: Arylformamidase; Author-Supplied Keyword: Formyl-kynurenine; Author-Supplied Keyword: Kynurenic acid; Author-Supplied Keyword: Kynurenine; Author-Supplied Keyword: Kynurenine formamidase; Author-Supplied Keyword: Tryptophan; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bbagen.2005.03.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105172939
T1 - Educating correctional health care providers and inmates about drug-drug interactions: HIV-medications and illicit drugs.
AU - Macher A
AU - Kibble D
AU - Bryant K
AU - Cody A
AU - Pilcher T
AU - Jahn D
Y1 - 2005/06//
N1 - Accession Number: 105172939. Language: English. Entry Date: 20100604. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 101193278.
KW - Correctional Health Services
KW - Drug Interactions -- Education
KW - Health Education
KW - HIV Infections -- Drug Therapy
KW - Street Drugs
KW - Access to Information
KW - Clinical Exemplars
KW - Collaboration
KW - Education, Continuing
KW - Government Agencies
KW - Public Health Administration
KW - Ritonavir -- Adverse Effects
SP - 139
EP - 143
JO - Californian Journal of Health Promotion
JF - Californian Journal of Health Promotion
JA - CALIF J HEALTH PROMOT
VL - 3
IS - 2
CY - Fullerton, California
PB - California State University, Fullerton
AB - This paper demonstrates how federal clinicians are collaborating with correctional health care providers in a unique continuing education initiative regarding HIV-medications and drug-drug interactions. Three clinical cases are presented to illustrate the potential dangers associated with concomitant use of ritonavir (a frequently prescribed antiretroviral agent) and illicit drugs. Such clinical cases are regularly presented in an exemplar program that draws clinicians together to share current medical information and notes 'from the field' regarding problems that correctional health care providers and administrators are likely to face. Collaboration between federal clinicians, correctional and community health officials has resulted in a unique forum for disseminating medical information, and represents a prototypical method for broad-based health education.
SN - 1545-8717
AD - U.S. Department of Health and Human Services, USA; AMacher@hrsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Powers, John H.
AU - Lin, Daphne
AU - Ross, David
T1 - FDA Evaluation of Antimicrobials.
JO - CHEST
JF - CHEST
Y1 - 2005/06//
VL - 127
IS - 6
M3 - Letter
SP - 2298
EP - 2299
SN - 00123692
AB - Presents a letter to the editor about the United States Food and drug Administration's evaluation of antimicrobials.
KW - LETTERS to the editor
KW - ANTI-infective agents
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 17376680; Powers, John H. 1; Email Address: powersjoh@cder.fda.gov Lin, Daphne 1 Ross, David 1; Affiliation: 1: Center for Drug Evaluation and Research US Food and Drug Administration Rockville, MD; Source Info: Jun2005, Vol. 127 Issue 6, p2298; Subject Term: LETTERS to the editor; Subject Term: ANTI-infective agents; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Machuca, Ana
AU - Wood, Owen
AU - Lee, Sherwin
AU - Daniel, Sylvester
AU - Rios, Maria
AU - Wolfe, Nathan D.
AU - Carr, Jean K.
AU - Eitel, Mpoudi-Ngole
AU - Tamoufe, Ubald
AU - Torimiro, Judith Ndongo
AU - Burke, Donald
AU - Hewlett, Indira K.
T1 - Seroprevalence of Human T Cell Leukemia Virus in HIV Antibody- Negative Populations in Rural Cameroon.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/06//6/1/2005
VL - 40
IS - 11
M3 - Article
SP - 1673
EP - 1676
SN - 10584838
AB - Seven hundred forty-seven serum samples collected from humans in 4 separate rural village areas in Cameroon were examined for antibody to human T cell leukemia viruses (HTLVs) by use of an enzyme immunoassay followed by a Western blot assay. Of the 88 serum samples that the enzyme immunoassay found to be repeatedly reactive, the HTLV status of 49 samples was confirmed by Western blot assay to be HTLV type I, and the status of 6 samples was confirmed to be HTLV type II. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - Leukemia
KW - T cells
KW - Enzyme-linked immunosorbent assay
KW - Serum
KW - Immunoassay
N1 - Accession Number: 17001517; Machuca, Ana 1; Wood, Owen 2; Lee, Sherwin 2; Daniel, Sylvester 2; Rios, Maria 2; Wolfe, Nathan D. 3,4; Carr, Jean K. 3,4; Eitel, Mpoudi-Ngole 5; Tamoufe, Ubald 5; Torimiro, Judith Ndongo 5; Burke, Donald 3,4; Hewlett, Indira K. 2; Email Address: Hewlett@cber.fda.gov; Affiliations: 1: Division Diagnosticos, Qui mica Farmaceutica Bayer, Madrid, Spain.; 2: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Office of Blood Research and Review, United States Food and Drug Administration, Rockville.; 3: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; 4: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; 5: Army Health Research Center, Yaoundé, Cameroon.; Issue Info: 6/1/2005, Vol. 40 Issue 11, p1673; Thesaurus Term: HIV (Viruses); Subject Term: Leukemia; Subject Term: T cells; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Serum; Subject Term: Immunoassay; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Anand, K.J.S.
AU - Aranda, Jacob V.
AU - Berde, Charles B.
AU - Buckman, ShaAvhrée
AU - Capparelli, Edmund V.
AU - Carlo, Waldemar A.
AU - Hummel, Patricia
AU - Lantos, John
AU - Celeste Johnston, C.
AU - Tutag Lehr, Victoria
AU - Lynn, Anne M.
AU - Maxwell, Lynne G.
AU - Oberlander, Tim F.
AU - Raju, Tonse N.K.
AU - Soriano, Sulpicio G.
AU - Taddio, Anna
AU - Walco, Gary A.
T1 - Analgesia and anesthesia for neonates: Study design and ethical issues
JO - Clinical Therapeutics
JF - Clinical Therapeutics
Y1 - 2005/06//
VL - 27
IS - 6
M3 - Article
SP - 814
EP - 843
SN - 01492918
AB - Abstract: Objective:: The purpose of this article is to summarize the clinical, methodologic, and ethical considerations for researchers interested in designing future trials in neonatal analgesia and anesthesia, hopefully stimulating additional research in this field. Methods:: The MEDLINE, PubMed, EMBASE, and Cochrane register databases were searched using subject headings related to infant, newborn, neonate, analgesia, anesthesia, ethics, and study design. Cross-references and personal files were searched manually. Studies reporting original data or review articles related to these topics were assessed and critically evaluated by experts for each topical area. Data on population demographics, study characteristics, and cognitive and behavioral outcomes were abstracted and synthesized in a systematic manner and refined by group members. Data synthesis and results were reviewed by a panel of independent experts and presented to a wider audience including clinicians, scientists, regulatory personnel, and industry representatives at the Newborn Drug Development Initiative workshop. Recommendations were revised after extensive discussions at the workshop and between committee members. Results:: Designing clinical trials to investigate novel or currently available approaches for analgesia and anesthesia in neonates requires consideration of salient study designs and ethical issues. Conditions requiring treatment include pain/stress resulting from invasive procedures, surgical operations, inflammatory conditions, and routine neonatal intensive care. Study design considerations must define the inclusion and exclusion criteria, a rationale for stratification, the confounding effects of comorbid conditions, and other clinical factors. Significant ethical issues include the constraints of studying neonates, obtaining informed consent, making risk-benefit assessments, defining compensation or rewards for participation, safety considerations, the use of placebo controls, and the variability among institutional review boards in interpreting federal guidelines on human research. For optimal study design, investigators must formulate well-defined study questions, choose appropriate trial designs, estimate drug efficacy, calculate sample size, determine the duration of the studies, identify pharmacokinetic and pharmacodynamic parameters, and avoid drug-drug interactions. Specific outcome measures may include scoring on pain assessment scales, various biomarkers and their patterns of response, process outcomes (eg, length of stay, time to extubation), intermediate or long-term outcomes, and safety parameters. Conclusions:: Much more research is needed in this field to formulate a scientifically sound, evidence-based, and clinically useful framework for management of anesthesia and analgesia in neonates. Newer study designs and additional ethical dilemmas may be defined with accumulating data in this field. [Copyright &y& Elsevier]
AB - Copyright of Clinical Therapeutics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANESTHESIA
KW - NEWBORN infants
KW - INTERNET in medicine
KW - CLINICAL trials
KW - analgesia
KW - anesthesia
KW - infant
KW - neonate
KW - pain
KW - stress
N1 - Accession Number: 18243351; Anand, K.J.S. 1; Email Address: anandsunny@uams.edu Aranda, Jacob V. 2 Berde, Charles B. 3 Buckman, ShaAvhrée 4 Capparelli, Edmund V. 5 Carlo, Waldemar A. 6 Hummel, Patricia 7 Lantos, John 8 Celeste Johnston, C. 9 Tutag Lehr, Victoria 10 Lynn, Anne M. 11 Maxwell, Lynne G. 12 Oberlander, Tim F. 13 Raju, Tonse N.K. 14 Soriano, Sulpicio G. 15 Taddio, Anna 16 Walco, Gary A. 17; Affiliation: 1: Departments of Pediatrics, Anesthesiology, Neurobiology and Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 2: Department of Pediatrics, Pharmacology, and Pharmaceutical Sciences Network, Children's Hospital of Michigan, Detroit, Michigan, USA 3: Division of Pain Medicine and Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, Massachusetts, USA 4: Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA 5: Pediatric Pharmacology Research Unit, University of California, San Diego, California, USA 6: Division of Neonatology, University of Alabama, Birmingham, Alabama, USA 7: Developmental Follow-up Program, Loyola University Medical Center, Maywood, Illinois, USA 8: Departments of Pediatrics and Medicine, University of Chicago, Chicago, Illinois, USA 9: School of Nursing, McGill University, Montreal, Quebec, Canada 10: Department of Pharmacy Practice, Eugene Applebaum School of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA 11: Departments of Anesthesiology and Pediatrics, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, Washington, USA 12: Department of Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 13: Division of Developmental Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada 14: Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Rockville, Maryland, USA 15: Department of Anesthesia, Children's Hospital Boston, Boston, Massachusetts, USA 16: Population Health Sciences, Research Institute, and Department of Pharmacy, Hospital for Sick Children, Toronto, Ontario, Canada 17: Department of Pediatrics, Hackensack University Medical Center, Hackensack, New Jersey, USA; Source Info: Jun2005, Vol. 27 Issue 6, p814; Subject Term: ANESTHESIA; Subject Term: NEWBORN infants; Subject Term: INTERNET in medicine; Subject Term: CLINICAL trials; Author-Supplied Keyword: analgesia; Author-Supplied Keyword: anesthesia; Author-Supplied Keyword: infant; Author-Supplied Keyword: neonate; Author-Supplied Keyword: pain; Author-Supplied Keyword: stress; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 30p; Document Type: Article
L3 - 10.1016/j.clinthera.2005.06.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choi, Yunhee
AU - Ahn, Hongshik
AU - Chen, James J.
T1 - Regression trees for analysis of count data with extra Poisson variation
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2005/06//
VL - 49
IS - 3
M3 - Article
SP - 893
EP - 915
SN - 01679473
AB - Abstract: This article proposes methods for fitting piecewise loglinear models to count data with an extra-Poisson variation. Both SUPPORT (Statistica Sinica, 4 (1994) 143) and GUIDE (Statistica Sinica, 12 (2002) 361) are used for splitting methods. We developed a new bootstrap resampling method performed at each node of the tree to determine the proper size of a tree. The quasi-likelihood approach is used for fitting an extra-Poisson model at each stratum to take into account the extra variability. An adjusted Anscombe residual for the extra-Poisson model is used in this procedure. Performance of the proposed method is evaluated by a Monte Carlo simulation study. The proposed method is used to investigate geographic variability in mortality rates on lung cancer as well as effects of various demographic variability. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - MONTE Carlo method
KW - SIMULATION methods & models
KW - NUMERICAL analysis
KW - Carcinogenicity
KW - Generalized linear model
KW - Quasi-likelihood
KW - Recursive partitioning
N1 - Accession Number: 17229033; Choi, Yunhee 1 Ahn, Hongshik 2; Email Address: hahn@ams.stonybrook.edu Chen, James J. 3; Affiliation: 1: Department of Preventive Medicine, School of Medicine, Seoul National University, 28 Yongeon-Dong, Chongro-Gu, Korea 2: Department of Applied Mathematics and Statistics, Stony Brook University, Math Tower, Stony Brook, NY 11794-3600, USA 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Jun2005, Vol. 49 Issue 3, p893; Subject Term: REGRESSION analysis; Subject Term: MONTE Carlo method; Subject Term: SIMULATION methods & models; Subject Term: NUMERICAL analysis; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Generalized linear model; Author-Supplied Keyword: Quasi-likelihood; Author-Supplied Keyword: Recursive partitioning; Number of Pages: 23p; Document Type: Article
L3 - 10.1016/j.csda.2004.06.011
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Robison, Lee
T1 - A Spinster Physician Weeps While Speaking Her Sermon on Abstinence: A Sonnet without Rhyme.
JO - Dialogue: A Journal of Mormon Thought
JF - Dialogue: A Journal of Mormon Thought
Y1 - 2005///Summer2005
VL - 38
IS - 2
M3 - Poem
SP - 185
EP - 185
SN - 00122157
AB - Presents the poem "A Spinster Physician Weeps While Speaking Her Sermon on Abstinence: A Sonnet without Rhyme," by Lee Robison. First line: In her fiftieth year and all these other; Last line: and so her voice wavers as it pitches to preach.
KW - FICTION
KW - ROBISON, Lee
KW - SPINSTER Physician Weeps While Speaking Her Sermon on Abstinence, A (Poem)
N1 - Accession Number: 17695485; Robison, Lee 1; Affiliation: 1: Indian Health Service, Rockville, Maryland; Source Info: Summer2005, Vol. 38 Issue 2, p185; Subject Term: FICTION; Reviews & Products: SPINSTER Physician Weeps While Speaking Her Sermon on Abstinence, A (Poem); People: ROBISON, Lee; Number of Pages: 1p; Document Type: Poem
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weston, Ainsley
AU - Ensey, James S.
AU - Frye, Bonnie L.
T1 - DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-DPB1*0403.
JO - DNA Sequence
JF - DNA Sequence
Y1 - 2005/06//
VL - 16
IS - 3
M3 - Article
SP - 235
EP - 236
PB - Taylor & Francis Ltd
SN - 10425179
AB - Sequence determination using HLA-DPB1 allele-specific primers for a DNA sample donated by an African–American individual revealed the presence of a novel haplotype. This new allele was found as a heterozygote together with HLA-DPB1*0402 . The new allele was similar to HLA-DPB1*1601 , however, it varied in two single nucleotide polymorphisms resulting in alanine residues at positions 55 and 56 of the mature protein rather than aspartic acid and glutamic acid, respectively. Allele-specific DNA-sequence determination was verified by sequence determination in forward and reverse directions after cloning in pCR2.1. This cloning strategy resulted in DNA products representing 19 clones confirming the novel allele (GenBank accession number AY823995 and is now listed in the IMGT/HLA database as HLA-DPB1*0403 ) and 17 clones representing HLA-DPB1*0402 . [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA Sequence is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXONS (Genetics)
KW - NUCLEOTIDE sequence
KW - AFRICAN Americans
KW - NUCLEOTIDES
KW - GENETIC polymorphisms
KW - CLONING
KW - AY823995
KW - DNA sequence
KW - haplotypes
KW - HLA locus
KW - polymerase chain reaction
N1 - Accession Number: 17343070; Weston, Ainsley 1; Email Address: agw8@cdc.gov Ensey, James S. 1 Frye, Bonnie L. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA; Source Info: Jun2005, Vol. 16 Issue 3, p235; Subject Term: EXONS (Genetics); Subject Term: NUCLEOTIDE sequence; Subject Term: AFRICAN Americans; Subject Term: NUCLEOTIDES; Subject Term: GENETIC polymorphisms; Subject Term: CLONING; Author-Supplied Keyword: AY823995; Author-Supplied Keyword: DNA sequence; Author-Supplied Keyword: haplotypes; Author-Supplied Keyword: HLA locus; Author-Supplied Keyword: polymerase chain reaction; Number of Pages: 2p; Document Type: Article
L3 - 10.1080/10425170500061442
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gurley, Bill J.
AU - Gardner, Stephanie F.
AU - Hubbard, Martha A.
AU - Williams, D. Keith
AU - Gentry, W. Brooks
AU - Cui, Yanyan
AU - Ang, Catharina Y. W.
T1 - Clinical Assessment of Effects of Botanical Supplementation on Cytochrome P450 Phenotypes in the Elderly: St John’s Wort, Garlic Oil, Panax ginseng and Ginkgo biloba.
JO - Drugs & Aging
JF - Drugs & Aging
Y1 - 2005/06//
VL - 22
IS - 6
M3 - Article
SP - 525
EP - 539
PB - Springer Science & Business Media B.V.
SN - 1170229X
AB - Objectives: Elderly patients are more likely to ingest prescription medications concurrently with botanical supplements, and may therefore be vulnerable to herb-drug interactions. Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Some evidence suggests that CYP activity may decrease in the elderly. If so, herb-mediated changes in CYP activity may take on greater clinical relevance in this population. In this study, single timepoint, phenotypic metabolic ratios were used to determine whether long-term supplementation of St John's wort, garlic oil, Panax ginseng, and Ginkgo biloba affected CYP1A2, CYP2D6, CYP2E1 or CYP3A4 activity in elderly subjects. Methods: Twelve healthy volunteers between the ages of 60 and 76 years (mean age 67 years) were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before and at the end of supplementation. Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively. The content of purported 'active' phytochemicals was determined for each supplement. Results: Comparisons of pre- and post-St John's wort phenotypic ratios revealed significant induction of CYP3A4 (≈140%) and CYP2E1 activity (≈28%). Garlic oil inhibited CYP2E1 activity by approximately 22%. P. ginseng inhibition of CYP2D6 was statistically significant, but the magnitude of the effect (≈7%) did not appear to be clinically relevant. None of the supplements tested in this study appeared to affect CYP1A2 activity. Conclusions: Elderly subjects, like their younger counterparts, are susceptible to herb-mediated changes in CYP activity, especially those involving St John's wort. Pharmacokinetic herb-drug interactions stemming from alterations in CYP activity may adversely affect drug efficacy and/or toxicity. When compared with earlier studies that employed young subjects, the data suggest that some age-related changes in CYP responsivity to botanical supplementation may exist. Concomitant ingestion of botanical supplements with prescription medications, therefore, should be strongly discouraged in the elderly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drugs & Aging is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBAL medicine
KW - DRUGS -- Side effects
KW - BLOOD plasma
KW - ANESTHETICS
KW - METHYLXANTHINES
KW - DRUGS -- Effectiveness
KW - Cytochrome P450
KW - Elderly
KW - Garlic
KW - Herbal medicines
KW - Hypericum
N1 - Accession Number: 17434693; Gurley, Bill J. 1; Email Address: gurleybillyj@uams.edu Gardner, Stephanie F. 2 Hubbard, Martha A. 1 Williams, D. Keith 3 Gentry, W. Brooks 4 Cui, Yanyan 5 Ang, Catharina Y. W. 5; Affiliation: 1: Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 2: Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 3: Department of Biometry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 4: Department of Anesthesiology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 5: Division of Chemistry, National Center for Toxicological Research, Jefferson, Arkansas, USA.; Source Info: 2005, Vol. 22 Issue 6, p525; Subject Term: HERBAL medicine; Subject Term: DRUGS -- Side effects; Subject Term: BLOOD plasma; Subject Term: ANESTHETICS; Subject Term: METHYLXANTHINES; Subject Term: DRUGS -- Effectiveness; Author-Supplied Keyword: Cytochrome P450; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Garlic; Author-Supplied Keyword: Herbal medicines; Author-Supplied Keyword: Hypericum; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cole, Dana
AU - Drum, David J. V.
AU - Stallknecht, David E.
AU - White, David G.
AU - Lee, Margie D.
AU - Ayers, Sherry
AU - Sobsey, Mark
AU - Maurer, John J.
AU - Stalknecht, David E
T1 - Free-living Canada geese and antimicrobial resistance.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2005/06//
VL - 11
IS - 6
M3 - journal article
SP - 935
EP - 938
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We describe antimicrobial resistance among Escherichia coli isolated from free-living Canada Geese in Georgia and North Carolina (USA). Resistance patterns are compared to those reported by the National Antimicrobial Resistance Monitoring System. Canada Geese may be vectors of antimicrobial resistance and resistance genes in agricultural environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Escherichia coli
KW - Drugs
KW - Antibacterial agents
KW - Animal experimentation
KW - Animals -- Population biology
KW - Antibiotics
KW - Comparative studies
KW - Poultry
KW - Public health
KW - Research
KW - Genes
KW - Fecal microbiology
KW - Drug resistance in microorganisms
KW - Research -- Methodology
KW - Medical cooperation
KW - Microbial sensitivity tests
KW - Evaluation -- Research
KW - Drugs -- Physiological effect
KW - Georgia
KW - North Carolina
N1 - Accession Number: 17147942; Cole, Dana 1; Email Address: dacole@dhr.state.ga.us; Drum, David J. V. 2; Stallknecht, David E. 2; White, David G. 3; Lee, Margie D. 2; Ayers, Sherry 3; Sobsey, Mark 4; Maurer, John J. 2; Stalknecht, David E; Affiliations: 1: Georgia Division of Public Health, Atlanta, Georgia, USA; 2: University of Georgia, Athens, Georgia, USA; 3: US Food and Drug Administration, Laurel, Maryland, USA; 4: University of North Carolina, Chapel Hill, North Carolina, USA; Issue Info: Jun2005, Vol. 11 Issue 6, p935; Thesaurus Term: Anti-infective agents; Thesaurus Term: Escherichia coli; Thesaurus Term: Drugs; Thesaurus Term: Antibacterial agents; Thesaurus Term: Animal experimentation; Thesaurus Term: Animals -- Population biology; Thesaurus Term: Antibiotics; Thesaurus Term: Comparative studies; Thesaurus Term: Poultry; Thesaurus Term: Public health; Thesaurus Term: Research; Subject Term: Genes; Subject Term: Fecal microbiology; Subject Term: Drug resistance in microorganisms; Subject Term: Research -- Methodology; Subject Term: Medical cooperation; Subject Term: Microbial sensitivity tests; Subject Term: Evaluation -- Research; Subject Term: Drugs -- Physiological effect; Subject: Georgia; Subject: North Carolina; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: journal article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cheshire Jr., William P.
AU - Jones, Nancy L.
T1 - CAN ARTIFICIAL TECHNIQUES SUPPLY MORALLY NEUTRAL HUMAN EMBRYOS FOR RESEARCH?
JO - Ethics & Medicine: An International Journal of Bioethics
JF - Ethics & Medicine: An International Journal of Bioethics
Y1 - 2005///Summer2005
VL - 21
IS - 2
M3 - Article
SP - 73
EP - 88
SN - 0266688X
AB - Amidst controversy surrounding research on human embryos, biotechnology has conceived a substitute in the artificial human embryo. We examine the claim that novel embryos constructed artificially should be exempt from ethical restraints appropriate for research on embryos that come into being through natural processes. Morally relevant differences in intrinsic value depend on the sense in which the entity may be artificial, whether in regard to constituent matter, genetic or cellular form, generative means, or intended purpose. Considering each of these Aristotelian categories from a physicalist viewpoint, technology can achieve only limited degrees of artificiality because redesigned embryos still retain most of their natural features and relationships. From an essentialist viewpoint, the very limits of technology preclude the capability of manipulating the fundamental nature or essence of the individual who, even at the embryonic stage of life, cannot be made to be artificial through and through. A human may possess artificially contributed attributes but cannot be an artificial being. Classification of novel human organisms as artificial, therefore, is insufficient grounds by which to relinquish the principle that human moral status should be recognized for all living beings of human origin. In uncertain cases, at least the possibility of special human moral status should be considered present in organisms that are derived asexually, are developmentally defective, or are otherwise technologically altered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Ethics & Medicine: An International Journal of Bioethics is the property of Bioethics Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN embryos
KW - BIOTECHNOLOGY
KW - MEDICAL ethics
KW - HUMAN reproductive technology
KW - MEDICAL technology
N1 - Accession Number: 18346663; Cheshire Jr., William P. 1,2 Jones, Nancy L. 3,4; Affiliation: 1: Associate Professor of Neurology, Mayo Clinic, Jacksonville, Florida 2: Director of Biotechnology Ethics, The Center for Bioethics and Human Dignity 3: Associate Professor of Pathology, Wake Forest University School of Medicine 4: U.S. Secretary of Health and Human Services Secretary's Advisory Committee on Human Research Protection; Source Info: Summer2005, Vol. 21 Issue 2, p73; Subject Term: HUMAN embryos; Subject Term: BIOTECHNOLOGY; Subject Term: MEDICAL ethics; Subject Term: HUMAN reproductive technology; Subject Term: MEDICAL technology; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - (Kosebalaban) Tokatli, Figen
AU - Cinar, Ali
AU - Schlesser, Joseph E.
T1 - HACCP with multivariate process monitoring and fault diagnosis techniques: application to a food pasteurization process
JO - Food Control
JF - Food Control
Y1 - 2005/06//
VL - 16
IS - 5
M3 - Article
SP - 411
EP - 422
SN - 09567135
AB - Multivariate statistical process monitoring (SPM), and fault detection and diagnosis (FDD) methods are developed to monitor the critical control points (CCPs) in a continuous food pasteurization process. Multivariate SPM techniques effectively use information from all process variables to detect abnormal process behavior. Fault diagnosis techniques isolate the source cause of the deviation in process variable(s). The methods developed are illustrated by implementing them to monitor the critical control points and diagnose causes of abnormal operation of a high temperature short time (HTST) pasteurization pilot plant. The detection power of multivariate SPM and FDD techniques over univariate SPM techniques is shown and their integrated use to ensure the product safety and quality in food processes is demonstrated. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD industry
KW - HIGH temperatures
KW - PRODUCT safety
KW - FOOD -- Quality
KW - Fault diagnosis
KW - HACCP
KW - Multivariate statistical process monitoring
N1 - Accession Number: 15583852; (Kosebalaban) Tokatli, Figen 1 Cinar, Ali 1; Email Address: cinar@iit.edu Schlesser, Joseph E. 2; Affiliation: 1: Department Chemical and Environmental Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA 2: National Center for Food Safety and Technology, US Food and Drug Administration, Summit-Argo, IL 60501, USA; Source Info: Jun2005, Vol. 16 Issue 5, p411; Subject Term: FOOD industry; Subject Term: HIGH temperatures; Subject Term: PRODUCT safety; Subject Term: FOOD -- Quality; Author-Supplied Keyword: Fault diagnosis; Author-Supplied Keyword: HACCP; Author-Supplied Keyword: Multivariate statistical process monitoring; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.foodcont.2004.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ranamukhaarachchi, Daya G.
AU - Unger, Elizabeth R.
AU - Vernon, Suzanne D.
AU - Lee, Daisy
AU - Rajeevan, Mangalathu S.
T1 - Gene expression profiling of dysplastic differentiation in cervical epithelial cells harboring human papillomavirus 16
JO - Genomics
JF - Genomics
Y1 - 2005/06//
VL - 85
IS - 6
M3 - Article
SP - 727
EP - 738
SN - 08887543
AB - Abstract: Molecular events occurring with high-risk human papillomavirus (HPV)-associated dysplastic differentiation of cervical epithelial cells are largely unknown. This study used differential display PCR to identify expression changes between nondifferentiating monolayer and differentiated organotypic (raft) cultures of W12 keratinocytes. These cells were originally derived from a clinical biopsy of HPV 16-positive dysplastic cervical epithelium and retain high-risk HPV 16 and the ability to differentiate, albeit with dysplastic morphology. Using this model system we identified 84 genes with changed expression during dysplastic differentiation. Most (70/84, ≈80%) were down-regulated with differentiation, consistent with a restriction of expression during terminal differentiation. Twenty-two genes had no known function and 6 novel expressed sequence tags were identified among this group. Of the 62 genes with known functions, 25 belonged to transcription-, translation-, and posttranslation-related categories and 30 had functions associated with neoplastic initiation/progression, calcium signaling, epithelial differentiation, and structure remodeling. Some of the genes with altered expression identified in this model of dysplastic differentiation may be useful biomarkers for early detection of cervical neoplasia and other HPV-associated oropharyngeal and anogenital cancers. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - EPITHELIAL cells
KW - MORPHOLOGY
KW - PAPILLOMAVIRUSES
N1 - Accession Number: 17809128; Ranamukhaarachchi, Daya G. Unger, Elizabeth R. 1 Vernon, Suzanne D. 1 Lee, Daisy 1 Rajeevan, Mangalathu S.; Email Address: mor4@cdc.gov; Affiliation: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA; Source Info: Jun2005, Vol. 85 Issue 6, p727; Subject Term: GENE expression; Subject Term: EPITHELIAL cells; Subject Term: MORPHOLOGY; Subject Term: PAPILLOMAVIRUSES; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ygeno.2005.02.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106383903
T1 - Commentary -- assessing the impact of managed care patient protection laws: problems and pitfalls.
AU - Hillinger FJ
Y1 - 2005/06//
N1 - Accession Number: 106383903. Language: English. Entry Date: 20060120. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Sloan FA, Rattliff JR, Hall MA. Impacts of managed care patient protection laws on health services utilization and patient satisfaction with care. (HEALTH SERV RES) Jun2005; 40 (3): 647-667. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Health Resource Utilization
KW - Managed Care Programs -- Legislation and Jurisprudence -- United States
KW - Patient Advocacy
KW - Patient Satisfaction
KW - Patient Attitudes
KW - Patient Rights
KW - Surveys
KW - United States
SP - 669
EP - 674
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 40
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Economist, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850
U2 - PMID: 15960685.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jones, S. J.
AU - Lyons, R. A.
AU - John, A.
AU - Palmer, S. R.
T1 - Traffic calming policy can reduce inequalities in child pedestrian injuries: database study.
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
Y1 - 2005/06//
VL - 11
IS - 3
M3 - Article
SP - 152
EP - 156
SN - 13538047
AB - Objectives: To determine whether area wide traffic calming distribution reflects known inequalities in child pedestrian injury rates. To determine whether traffic calming is associated with changes in childhood pedestrian injury rates. Design: Small area ecological study, longitudinal analysis of injury rates with cross sectional analysis of traffic calming and method of travel to school. Settings: Two cities in the United Kingdom. Participants: 4-16 year old children between 1992 and 2000. Main outcome measures: Area wide traffic calming distribution by area deprivation status and changes in injury rate/1000. Results: The most deprived fourth of city A had 4.8 times (95% CI 3.71 to 6.22) the number of traffic calming features per 1000 population compared with the most affluent fourth. Injury rates among the most deprived dropped from 9.42 to 5.07 from 1992-94 to 1998-2000(95% CI for change 2.82 to 5.91). In city B, the traffic calming ratio of the most to least deprived fourth was 1 .88 (95% CI 1.46 to 2.42); injury rates in the deprived areas dropped from 8.92 to 7.46 (95% CI for change -0.84 to 3.77). Similar proportions of 9-12 year olds walked to school in both cities. Conclusions: Area wide traffic calming is associated with absolute reductions in child pedestrian injury rates and reductions in relative inequalities in child pedestrian injury rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Injury Prevention (1353-8047) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTCOME assessment (Medical care)
KW - MEDICAL care -- Evaluation
KW - PEDESTRIAN accidents
KW - TRAFFIC accidents
KW - CITY traffic
KW - TRAFFIC safety
N1 - Accession Number: 17425658; Jones, S. J. 1 Lyons, R. A. 2; Email Address: r.a.lyons@swansea.ac.uk John, A. 3 Palmer, S. R. 1; Affiliation: 1: Department of Epidemiology Statistics and Public Health, Cardiff University, Cardiff, UK. 2: Center for Health Improvement Research and Evolution University of Wales Swansea, Swansea, UK. 3: National Public Health Service for Wales Swansea Office, Swansea UK.; Source Info: Jun2005, Vol. 11 Issue 3, p152; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL care -- Evaluation; Subject Term: PEDESTRIAN accidents; Subject Term: TRAFFIC accidents; Subject Term: CITY traffic; Subject Term: TRAFFIC safety; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1136/ip.2004.007252
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kong, Yong-Ku
AU - Lowe, Brian D.
T1 - Optimal cylindrical handle diameter for grip force tasks
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2005/06//
VL - 35
IS - 6
M3 - Article
SP - 495
EP - 507
SN - 01698141
AB - Abstract: This study tested maximum grip force on cylindrical aluminum handles to evaluate the relationships between handle diameter (25–50mm diameter handles), perceived comfort, finger and phalange force distribution, and electromyographic efficiency of finger flexor and extensor muscle activity. A force glove system containing 16 thin profile force sensors was developed to measure finger and phalangeal forces on the cylindrical handles. Participants () rated the mid-sized handles (30, 35 and 40mm) as the most comfortable for maximum grip force exertions. Using a polynomial regression the handle diameter that maximized subjective comfort was calculated as a function of the user''s hand length. This optimal handle diameter was 19.7% of the user''s hand length. Total finger force capability was inversely related with handle diameter. Electromyographic amplitude of the primary flexor and extensor was unaffected by handle diameter, so the efficiency of the muscle electrical activity followed the same relationship with handle diameter as total finger force. Individual finger and phalange force distributions were examined to evaluate their relationship with perceived comfort. A non-uniform finger/phalange force distribution, in which finger force was proportional to finger muscle capabilities, exhibited a stronger correlation with subjective ratings of comfort than a uniform finger/phalange force distribution. Relevance to industry: Results obtained in this study will provide guidelines to hand-tool designers and manufacturers for maximizing handle comfort based on the user''s hand size. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Regression analysis
KW - Procedure manuals
KW - Detectors
KW - Businessmen
KW - Finger force
KW - Handle evaluation
KW - Subjective comfort rating
KW - Tool design
N1 - Accession Number: 17673137; Kong, Yong-Ku; Email Address: ykong@cdc.gov; Lowe, Brian D. 1; Affiliations: 1: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226, USA; Issue Info: Jun2005, Vol. 35 Issue 6, p495; Subject Term: Regression analysis; Subject Term: Procedure manuals; Subject Term: Detectors; Subject Term: Businessmen; Author-Supplied Keyword: Finger force; Author-Supplied Keyword: Handle evaluation; Author-Supplied Keyword: Subjective comfort rating; Author-Supplied Keyword: Tool design; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.ergon.2004.11.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kodell, Ralph L.
T1 - Managing uncertainty in health risk assessment.
JO - International Journal of Risk Assessment & Management
JF - International Journal of Risk Assessment & Management
Y1 - 2005/06//
VL - 5
IS - 2/3/4
M3 - Article
SP - 193
EP - 205
SN - 14668297
AB - The process of risk (safety) assessment used to determine negligible-risk levels of human exposure to toxicants is subject to a number of sources of uncertainty. In addition to the common uncertainties related to high-to-low-dose extrapolation, interspecies extrapolation and intraspecies extrapolation, there can be uncertainty associated with extrapolation to alternative routes and durations of exposure. Sampling variation is an important source of uncertainty. It is essential that the various sources of uncertainty be taken into account in the risk and exposure extrapolations, but the total uncertainty should be managed in such a way as to avoid setting overly conservative safe exposures. This article discusses a unifying benchmark-dose approach to risk assessment for carcinogenic and noncarcinogenic health effects, and describes a formal quantitative procedure for managing uncertainty that is less conservative than the common practice of reducing a point of departure on a dose-response curve by a product of uncertainty factors to achieve a safe level of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Risk Assessment & Management is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Risk assessment
KW - Numerical analysis
KW - Environmental health
KW - Approximation theory
KW - Risk management in business
KW - benchmark dose
KW - exposure
KW - extrapolation
KW - hazardous substances
KW - health risk assessment
KW - negligible risk
KW - NOAEL
KW - reference dose
KW - safety assessment
KW - toxic substances
KW - uncertainty management
KW - variability
N1 - Accession Number: 18375845; Kodell, Ralph L. 1; Email Address: rkodell@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.; Issue Info: 2005, Vol. 5 Issue 2/3/4, p193; Thesaurus Term: Health risk assessment; Thesaurus Term: Risk assessment; Thesaurus Term: Numerical analysis; Thesaurus Term: Environmental health; Subject Term: Approximation theory; Subject Term: Risk management in business; Author-Supplied Keyword: benchmark dose; Author-Supplied Keyword: exposure; Author-Supplied Keyword: extrapolation; Author-Supplied Keyword: hazardous substances; Author-Supplied Keyword: health risk assessment; Author-Supplied Keyword: negligible risk; Author-Supplied Keyword: NOAEL; Author-Supplied Keyword: reference dose; Author-Supplied Keyword: safety assessment; Author-Supplied Keyword: toxic substances; Author-Supplied Keyword: uncertainty management; Author-Supplied Keyword: variability; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bailer, A. John
AU - Wheeler, Mathew
AU - Dankovic, David
AU - Noble, Robert
AU - Bena, James
T1 - Incorporating uncertainty and variability in the assessment of occupational hazards.
JO - International Journal of Risk Assessment & Management
JF - International Journal of Risk Assessment & Management
Y1 - 2005/06//
VL - 5
IS - 2/3/4
M3 - Article
SP - 344
EP - 357
SN - 14668297
AB - Uncertainty reflects ignorance associated with population traits (e.g. average exposure levels to a contaminant), with models used to predict risk (e.g. which statistical model is correct), and with a host of other considerations. Variability reflects an intrinsic property of a system (e.g. body mass indices possess a distribution across a population). The incorporation of uncertainty and variability in the assessment of occupational hazards is an important objective. General issues of uncertainty and variability in occupational risk estimation are discussed. This is followed by three illustrations where: firstly, the impact of variability in an exposure assessment and sampling variability in a regression model on risk estimates is considered; secondly, the impact of uncertainty in the size of a workforce on rate modelling is considered; and thirdly, the impact of using different models to predict risk is considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Risk Assessment & Management is the property of Inderscience Enterprises Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Occupational hazards
KW - Population
KW - Health risk assessment
KW - Regression analysis
KW - Risk management in business
KW - exposure assessment
KW - model averaging
KW - occupational hazards
KW - occupational risk
KW - PBPK models
KW - rate modelling
KW - regression models
KW - risk assessment
KW - risk estimation
KW - sampling variability
KW - uncertainty
KW - variability
KW - workforce size
KW - workplace health and safety
N1 - Accession Number: 18375854; Bailer, A. John 1,2; Email Address: baileraj@muohio.edu; Wheeler, Mathew 2; Email Address: aez0@cdc.gov; Dankovic, David 2; Email Address: dad4@cdc.gov; Noble, Robert 1; Email Address: noblerb@muohio.edu; Bena, James 3; Email Address: jbena@bio.ri.ccf.org; Affiliations: 1: Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA.; 2: Risk Evaluation Branch, Education and Information Division, National Institute for Occupational Safety and Health/CDC, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; 3: Cleveland Clinic Foundation, Department of Biostatistics and Epidemiology/Wb4, 9500 Euclid Ave., Cleveland, OH 44195, USA.; Issue Info: 2005, Vol. 5 Issue 2/3/4, p344; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational hazards; Thesaurus Term: Population; Thesaurus Term: Health risk assessment; Subject Term: Regression analysis; Subject Term: Risk management in business; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: model averaging; Author-Supplied Keyword: occupational hazards; Author-Supplied Keyword: occupational risk; Author-Supplied Keyword: PBPK models; Author-Supplied Keyword: rate modelling; Author-Supplied Keyword: regression models; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: risk estimation; Author-Supplied Keyword: sampling variability; Author-Supplied Keyword: uncertainty; Author-Supplied Keyword: variability; Author-Supplied Keyword: workforce size; Author-Supplied Keyword: workplace health and safety; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weinick, Robin M.
AU - Byron, Sepheen C.
AU - Bierman, Arlene S.
T1 - Who Can't Pay for Health Care?
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2005/06//
VL - 20
IS - 6
M3 - Article
SP - 504
EP - 509
SN - 08848734
AB - In an era of rising health care costs, many Americans experience difficulty paying for needed health care services. With costs expected to continue rising, changes to private insurance plans and public programs aimed at containing costs may have a negative impact on Americans' ability to afford care. To provide estimates of the number of adults who avoid health care due to cost, and to assess the association of income, functional status, and type of insurance with the extent to which people with health insurance report financial barriers. Cross-sectional observational study using data from the Commonwealth Fund 2001 Health Care Quality Survey, a nationally representative telephone survey. U.S. adults age 18 and older ( N=6,722). Six measures of avoiding health care due to cost, including delaying or not seeking care; not filling prescription medicines; and not following recommended treatment plan. The proportion of Americans with difficulty affording health care varies by income and health insurance coverage. Overall, 16.9% of Americans report at least 1 financial barrier. Among those with private insurance, the poor (28.4%), near poor (24.3%), and those with functional impairments (22.9%) were more likely to report avoiding care due to cost. In multivariate models, the uninsured are more likely (OR, 2.3; 95% CI, 1.7 to 3.0) to have trouble paying for care. Independent of insurance coverage and other demographic characteristics, the poor (OR, 3.6; 95% CI, 2.1 to 4.6), near poor (OR, 2.1; 95% CI, 1.9 to 3.7), and middle-income (OR, 1.8; 95% CI, 1.3 to 2.5) respondents as well as those with functional impairments (OR, 1.6; 95% CI, 1.3 to 2.0) are significantly more likely to avoid care due to cost. Privately and publicly insured individuals who have low incomes or functional impairments encounter significant financial barriers to care despite having health insurance. Proposals to expand health insurance will need to address these barriers in order to be effective. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MEDICAL care -- United States
KW - HEALTH insurance
KW - PUBLIC health
KW - TELEPHONE surveys
KW - UNITED States
KW - functional impairmen
KW - functional impairment
KW - health care affordability
KW - insurance coverage
KW - low-income populations
N1 - Accession Number: 17466108; Weinick, Robin M. 1,2 Byron, Sepheen C. 1; Email Address: sbyron@ahrq.gov Bierman, Arlene S. 2; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, MD, USA. 2: St. Michael's Hospital and Faculties of Nursing and Medicine, University of Toronto, Toronto, Canada.; Source Info: Jun2005, Vol. 20 Issue 6, p504; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care -- United States; Subject Term: HEALTH insurance; Subject Term: PUBLIC health; Subject Term: TELEPHONE surveys; Subject Term: UNITED States; Author-Supplied Keyword: functional impairmen; Author-Supplied Keyword: functional impairment; Author-Supplied Keyword: health care affordability; Author-Supplied Keyword: insurance coverage; Author-Supplied Keyword: low-income populations; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1525-1497.2005.0087.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106532408
T1 - AHRQ link. AHRQ quality and safety initiatives.
AU - Clancy CM
Y1 - 2005/06//2005 Jun
N1 - Accession Number: 106532408. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 101238023.
KW - Quality of Health Care
KW - United States Agency for Healthcare Research and Quality
KW - Information Technology
KW - Patient Safety
KW - Software
SP - 354
EP - 356
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 31
IS - 6
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1553-7250
AD - Director, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106205342
T1 - Integrating behavioral aspects into community preparedness and response systems.
AU - Reissman DB
AU - Spencer S
AU - Tanielian TL
AU - Stein BD
Y1 - 2005/06//
N1 - Accession Number: 106205342. Language: English. Entry Date: 20070105. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9802540.
KW - Disaster Planning -- Psychosocial Factors
KW - Terrorism -- Prevention and Control
KW - Behavioral Changes
KW - Community Assessment
KW - Disasters -- Psychosocial Factors
KW - Discrimination
KW - Emergency Medical Services
KW - Financing, Government
KW - Hardiness
KW - Health Promotion
KW - Interinstitutional Relations
KW - Life Change Events
KW - Program Evaluation
KW - Public Health
KW - Risk Assessment
KW - Safety
KW - Somatoform Disorders -- Prevention and Control
KW - Stress Disorders, Post-Traumatic -- Prevention and Control
KW - Support, Psychosocial
KW - United States
SP - 707
EP - 720
JO - Journal of Aggression, Maltreatment & Trauma
JF - Journal of Aggression, Maltreatment & Trauma
JA - J AGGRESSION MALTREAT TRAUMA
VL - 10
IS - 3/4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This article examines the role of psychosocial and behavioral dimensions of terrorism that influence community preparedness and homeland defense efforts. Public health interventions will fail if people do not follow the recommendations. A broader public health model is applied to help identify the interactions between risk and safety appraisals, social factors, and behavioral response to uncertain and stressful situations. Community preparedness would benefit by linking disparate programmatic and advocacy initiatives that already exist. It stands to reason that improving the cohesiveness of existing systems of social organization would strengthen community resilience and serve as effective countermeasures for terrorism.
SN - 1092-6771
AD - Commander, U.S. Public Health Service, Senior Advisor for Disaster, Terrorism, and Mental Health, Office of the Director, Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention (CDC), 4770 Buford Highway, NE, Mailstop K-68, Atlanta, GA 30341-3742; dreissman@cdc.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhang, Juan Joanne
AU - Tsong Yi
AU - Lue Ping Zhao
T1 - Evaluation of Nine Strategies for Analyzing a cDNA Toxicology Microarray Data Set.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2005/06//
VL - 15
IS - 3
M3 - Article
SP - 403
EP - 418
PB - Taylor & Francis Ltd
SN - 10543406
AB - Microarray technology with two-color–based cDNA is commonly used for drug development, as well as for a much broader range of biomedical research. Among all the applications, two-group design is probably most commonly used for comparing, e.g., normal and abnormal tissue samples, tissues treated and untreated, or individuals responded and not responded to a drug. Despite the apparent simplicity, there are numerous methods for analyzing such data in a statistically rigorous manner. Here, we discuss nine different analytical strategies, each of which is derived under a set of “reasonable” assumptions. Some of them resemble methods developed for different contexts. In the absence of the truth, investigators should consider underlying assumptions before taking one or more of these strategies for analyzing data from a particular experiment. The issue here is what are the similarities and differences between these analytical strategies. We present these strategies in the context of an actual microarray experiment performed at the U.S. Food and Drug Administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - TOXICOLOGY
KW - DRUG development
KW - BIOCHIPS
KW - IMMOBILIZED nucleic acids
KW - MEDICAL research
KW - cDNA microarray
KW - False discovery rate (FDR)
KW - One- and two-group comparison
KW - Panel data analysis
KW - Replicates
KW - t -Tests
KW - t -Tests,
N1 - Accession Number: 17132523; Zhang, Juan Joanne 1 Tsong Yi 1 Lue Ping Zhao 2; Email Address: lzhao@fhcrc.org; Affiliation: 1: Quantitative Methods and Research Staff, Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA 2: Program of Biostatistics, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Source Info: Jun2005, Vol. 15 Issue 3, p403; Subject Term: DNA microarrays; Subject Term: TOXICOLOGY; Subject Term: DRUG development; Subject Term: BIOCHIPS; Subject Term: IMMOBILIZED nucleic acids; Subject Term: MEDICAL research; Author-Supplied Keyword: cDNA microarray; Author-Supplied Keyword: False discovery rate (FDR); Author-Supplied Keyword: One- and two-group comparison; Author-Supplied Keyword: Panel data analysis; Author-Supplied Keyword: Replicates; Author-Supplied Keyword: t -Tests; Author-Supplied Keyword: t -Tests,; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 16p; Document Type: Article
L3 - 10.1081/BIP-200056518
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Irony, Telba
T1 - A Review of: “Bayesian Approaches to Clinical Trials and Health-Care Evaluation”.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2005/06//
VL - 15
IS - 3
M3 - Book Review
SP - 527
EP - 529
PB - Taylor & Francis Ltd
SN - 10543406
AB - Reviews the book "Bayesian Approaches to Clinical Trials and Health-Care Evaluation," by D. J. Spiegelhalter, K. R. Abrams and J. P. Myles.
KW - CLINICAL trials
KW - NONFICTION
KW - SPIEGELHALTER, D. J.
KW - ABRAMS, K. R.
KW - MYLES, J. P.
KW - BAYESIAN Approaches to Clinical Trials & Health-Care Evaluation (Book)
N1 - Accession Number: 17132527; Irony, Telba 1; Affiliation: 1: Chief, General and Surgical Devices Branch Division of Biostatistics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD, 20850; Source Info: Jun2005, Vol. 15 Issue 3, p527; Subject Term: CLINICAL trials; Subject Term: NONFICTION; Reviews & Products: BAYESIAN Approaches to Clinical Trials & Health-Care Evaluation (Book); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: SPIEGELHALTER, D. J.; People: ABRAMS, K. R.; People: MYLES, J. P.; Number of Pages: 3p; Document Type: Book Review
L3 - 10.1081/BIP-200056556
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17132527&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ritter, Grant
AU - Reif, Sharon
AU - Gadzuk, Anita
AU - Krenzke, Thomas
AU - Mohadjer, Leyla
AU - Lee, Margaret
AU - Horgan, Constance M.
T1 - Incentive effects on cooperation rates and sample composition in the alcohol and drug services study.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2005/06//
VL - 30
IS - 2/3
M3 - Article
SP - 171
EP - 189
PB - IOS Press
SN - 07479662
AB - In the past, incentive payments have proven successful in increasing survey response rates. In particular, incentives have been shown to increase the yield rate for harder-to-interview respondents. Despite this success, incentives are not without controversy. Opponents note that incentives may make the survey appear less important, destroy civic responsibility, and create an unnecessary expectation. Over time researchers may have to pay sizable incentives to achieve the response rates obtained 20 years ago before the use of incentives was common. Incentives could also have a detrimental impact on sample composition. The Alcohol and Drug Services Study (ADSS) included an incentive payment sub-study as part of its client follow-up phase. The sample for this sub-study randomized clients into four groups. One group was paid $25, the amount received by other responding clients in the ADSS main study. Respondents in the other three groups were paid an alternative amount (i.e., $0, $10, or $35). In examining the impact of varying incentives to sampling benchmarks, such as response rate and sample composition, the ADSS incentive sub-study found that the fears of opponents concerning the use of incentives were substantially unfounded, at least among the substance abuse treatment clients in the follow-up phase of ADSS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONETARY incentives
KW - PAYMENT
KW - RESPONSE rates
KW - SAMPLING (Statistics)
KW - SURVEYS
KW - ALCOHOL
KW - DRUG abuse -- Study & teaching
KW - SUBSTANCE abuse
KW - SUBSTANCE abuse -- Treatment
N1 - Accession Number: 19251565; Ritter, Grant 1; Email Address: ritter@brandeis.edu; Reif, Sharon 1; Gadzuk, Anita 2; Krenzke, Thomas 3; Mohadjer, Leyla 3; Lee, Margaret 1; Horgan, Constance M. 1; Affiliations: 1: Schneider Institute for Health Policy, Brandeis University, Waltham, MA, USA; 2: Substance Abuse and Mental Health Services Administration, Rockville, MD, USA; 3: Statistical Group, WESTAT, Rockville, MD, USA; Issue Info: 2005, Vol. 30 Issue 2/3, p171; Thesaurus Term: MONETARY incentives; Thesaurus Term: PAYMENT; Thesaurus Term: RESPONSE rates; Thesaurus Term: SAMPLING (Statistics); Subject Term: SURVEYS; Subject Term: ALCOHOL; Subject Term: DRUG abuse -- Study & teaching; Subject Term: SUBSTANCE abuse; Subject Term: SUBSTANCE abuse -- Treatment; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 19p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wright, Douglas
AU - Bowman, Katherine
AU - Butler, Dicy
AU - Eyerman, Joe
T1 - Non-response bias from the national household survey on drug abuse incentive experiment.
JO - Journal of Economic & Social Measurement
JF - Journal of Economic & Social Measurement
Y1 - 2005/06//
VL - 30
IS - 2/3
M3 - Article
SP - 219
EP - 231
PB - IOS Press
SN - 07479662
AB - The purpose of this paper is to determine whether giving a monetary incentive has an effect on reported drug use rates. Sampling weights were adjusted to account for the differential response rates between the incentive and non-incentive cases. Then logistic regression models of substance use were fitted as a function of the incentive level ($0, $20, and $40) while controlling on other variables that might mask the relationship. The incentive had a statistically significant effect on the reported past-year use of marijuana and on past-month use of cocaine, but no effect on past-month or lifetime use of marijuana. Offering a monetary incentive to respond can result in different estimated prevalence rates for the incentive and non-incentive groups. The extent of the difference may be a function of the perceived level of social disapproval of the substance and the reference period (past month, past year, or any past use). Some of the difference appears to be due to differences in substance use rates between the group that had traditionally reported without an incentive and the new group attracted by the incentive. Other differences appear to result from more honest reporting among the traditional respondents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic & Social Measurement is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONETARY incentives
KW - SAMPLING (Statistics)
KW - RESPONSE rates
KW - STATISTICS
KW - DRUG abuse
KW - LOGISTIC regression analysis
KW - SUBSTANCE abuse
KW - MARIJUANA
KW - COCAINE
N1 - Accession Number: 19251563; Wright, Douglas 1; Email Address: douglas.wright@samhsa.hhs.gov; Bowman, Katherine 2; Butler, Dicy 1; Eyerman, Joe 3; Affiliations: 1: Substance Abuse and Mental Health Services Administration, Rockville, MD, USA; 2: Statistics Research Division, RTI International, Research Triangle Park, NC, USA; 3: Survey Research Division, RTI International, Research Triangle Park, NC, USA; Issue Info: 2005, Vol. 30 Issue 2/3, p219; Thesaurus Term: MONETARY incentives; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: RESPONSE rates; Thesaurus Term: STATISTICS; Subject Term: DRUG abuse; Subject Term: LOGISTIC regression analysis; Subject Term: SUBSTANCE abuse; Subject Term: MARIJUANA; Subject Term: COCAINE; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 13p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - CONF
AU - Miller, Arthur J.
AU - Hileman, Christine L.
AU - Droby, Samir
AU - Paster, Nachman
T1 - Science and Technology Based Countermeasures to Foodborne Terrorism: Introduction.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Proceeding
SP - 1253
EP - 1255
SN - 0362028X
AB - Highlights the workshop on countermeasures to foodborne terrorism in Shepherdstown, West Virginia. Focus of the workshop on technology-based efforts; List of conference objectives; Total number of conference attendees.
KW - Technology
KW - Forums (Discussion & debate)
KW - Conferences & conventions
KW - Terrorism
KW - Conferences & conventions -- Attendance
KW - Shepherdstown (W. Va.)
KW - West Virginia
N1 - Accession Number: 17305906; Miller, Arthur J. 1; Email Address: amiller@cfsan.fda.gov; Hileman, Christine L. 1; Droby, Samir 2; Paster, Nachman 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, U.S. Department of Health and Human Services, College Park, Maryland 21074, USA; 2: Agricultural Research Organization, Volcani Center, Bet Dagan, 50250 Israel; Issue Info: Jun2005, Vol. 68 Issue 6, p1253; Thesaurus Term: Technology; Subject Term: Forums (Discussion & debate); Subject Term: Conferences & conventions; Subject Term: Terrorism; Subject Term: Conferences & conventions -- Attendance; Subject: Shepherdstown (W. Va.); Subject: West Virginia; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Document Type: Proceeding
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Miller, Arthur J.
AU - Hileman, Christine L.
AU - Droby, Samir
AU - Paster, Nachman
T1 - Science and Technology Based Countermeasures to Foodborne Terrorism: Introduction.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Proceeding
SP - 1253
EP - 1255
SN - 0362028X
AB - Highlights the workshop on countermeasures to foodborne terrorism in Shepherdstown, West Virginia. Focus of the workshop on technology-based efforts; List of conference objectives; Total number of conference attendees.
KW - FORUMS (Discussion & debate)
KW - CONFERENCES & conventions
KW - TERRORISM
KW - TECHNOLOGY
KW - CONFERENCES & conventions -- Attendance
KW - SHEPHERDSTOWN (W. Va.)
KW - WEST Virginia
N1 - Accession Number: 17305906; Miller, Arthur J. 1; Email Address: amiller@cfsan.fda.gov Hileman, Christine L. 1 Droby, Samir 2 Paster, Nachman 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, U.S. Department of Health and Human Services, College Park, Maryland 21074, USA 2: Agricultural Research Organization, Volcani Center, Bet Dagan, 50250 Israel; Source Info: Jun2005, Vol. 68 Issue 6, p1253; Subject Term: FORUMS (Discussion & debate); Subject Term: CONFERENCES & conventions; Subject Term: TERRORISM; Subject Term: TECHNOLOGY; Subject Term: CONFERENCES & conventions -- Attendance; Subject Term: SHEPHERDSTOWN (W. Va.); Subject Term: WEST Virginia; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sharma, Shashi K.
AU - Whiting, Richard C.
T1 - Methods for Detection of Clostridium botulinum Toxin in Foods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Article
SP - 1256
EP - 1263
SN - 0362028X
AB - Botulism is a deadly disease caused by ingestion of the preformed neurotoxin produced from the anaerobic spore-forming bacteria Clostridium botulinum. Botulinum neurotoxins are the most poisonous toxins known and have been a concern in the food industry for a long time. Therefore, rapid identification of botulinum neurotoxin using molecular and biochemical techniques is an essential component in the establishment of coordinated laboratory response systems and is the focus of current research and development. Because of the extreme toxicity of botulinum neurotoxin, some confirmatory testing with the mouse bioassay is still necessary, but rapid methods capable of screening large numbers of samples are also needed. This review is focused on the development of several detection methods for botulinum neurotoxins in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Botulism
KW - Food poisoning
KW - Neurotoxic agents
KW - Food industry
KW - Clostridium diseases
KW - Clostridium botulinum
KW - Rapid methods (Microbiology)
N1 - Accession Number: 17305907; Sharma, Shashi K. 1; Email Address: shashi.sharma@cfsan.fda.gov; Whiting, Richard C. 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740-3835, USA; Issue Info: Jun2005, Vol. 68 Issue 6, p1256; Thesaurus Term: Botulism; Thesaurus Term: Food poisoning; Thesaurus Term: Neurotoxic agents; Thesaurus Term: Food industry; Subject Term: Clostridium diseases; Subject Term: Clostridium botulinum; Subject Term: Rapid methods (Microbiology); NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bennett, Reginald W.
T1 - Staphylococcal Enterotoxin and Its Rapid Identification in Foods by Enzyme-Linked Immunosorbent Assay— Based Methodology.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Article
SP - 1264
EP - 1270
SN - 0362028X
AB - The problem of Staphylococcus aureus and other species as contaminants in the food supply remains significant on a global level. Time and temperature abuse of a food product contaminated with enterotoxigenic staphylococci can result in formation of enterotoxin, which can produce foodborne illness when the product is ingested. Between 100 and 200 ng of enterotoxin can cause symptoms consistent with staphylococcal intoxication. Although humans are the primary reservoirs of contamination, animals, air, dust, and food contact surfaces can serve as vehicles in the transfer of this pathogen to the food supply. Foods may become contaminated during production or processing and in homes or food establishments, where the organism can proliferate to high concentrations and subsequently produce enterotoxin. The staphylococcal enterotoxins are highly heat stable and can remain biologically active after exposure to retort temperatures. Prior to the development of serological methods for the identification of enterotoxin, monkeys (gastric intubation) and later kittens (intravenous injection) were used in assays for toxin detection. When enterotoxins were identified as mature proteins that were antigenic, serological assays were developed for use in the laboratory analysis of foods suspected of containing preformed enterotoxin. More recently developed methods are tracer-labeled immunoassays. Of these methods, the enzyme-linked immunosorbent assays are highly specific, highly sensitive, and rapid for the detection of enterotoxin in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Food pathogens
KW - Enterotoxins
KW - Staphylococcus aureus
KW - Rapid methods (Microbiology)
KW - Enzyme-linked immunosorbent assay
N1 - Accession Number: 17305908; Bennett, Reginald W. 1; Email Address: reginald.bennett@cfsan.fda.gov; Affiliations: 1: U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Jun2005, Vol. 68 Issue 6, p1264; Thesaurus Term: Food contamination; Thesaurus Term: Food pathogens; Subject Term: Enterotoxins; Subject Term: Staphylococcus aureus; Subject Term: Rapid methods (Microbiology); Subject Term: Enzyme-linked immunosorbent assay; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cebula, Thomas A.
AU - Jackson, Scott A.
AU - Brown, Eric W.
AU - Goswami, Biswendu
AU - LeClerc, J. Eugene
T1 - Chips and SNPs, Bugs and Thugs: A Molecular Sleuthing Perspective.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Article
SP - 1271
EP - 1284
SN - 0362028X
AB - Recent events both here and abroad have focused attention on the need for ensuring a safe and secure food supply. Although much has been written about the potential of particular select agents in bioterrorism, we must consider seriously the more mundane pathogens, especially those that have been implicated previously in foodborne outbreaks of human disease, as possible agents of bioterrorism. Given their evolutionary history, the enteric pathogens are more diverse than agents such as Bacillus anthracis, Francisella tularensis, or Yersinia pestis. This greater diversity, however, is a double-edged sword; although diversity affords the opportunity for unequivocal identification of an organism without the need for whole-genome sequencing, the same diversity can confound definitive forensic identification if boundaries are not well defined. Here, we discuss molecular approaches used for the identification of Salmonella enterica, Escherichia coli, and Shigella spp. and viral pathogens and discuss the utility of these approaches to the field of microbial molecular forensics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bioterrorism
KW - Food supply
KW - Food pathogens
KW - Foodborne diseases
KW - Salmonella
KW - Shigella
KW - Escherichia coli
N1 - Accession Number: 17305909; Cebula, Thomas A. 1; Email Address: tcebula@cfsan.fda.gov; Jackson, Scott A. 1; Brown, Eric W. 1; Goswami, Biswendu 1; LeClerc, J. Eugene 1; Affiliations: 1: Division of Molecular Biology (HFS-025), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland 20708, USA; Issue Info: Jun2005, Vol. 68 Issue 6, p1271; Thesaurus Term: Bioterrorism; Thesaurus Term: Food supply; Thesaurus Term: Food pathogens; Thesaurus Term: Foodborne diseases; Thesaurus Term: Salmonella; Thesaurus Term: Shigella; Thesaurus Term: Escherichia coli; Number of Pages: 14p; Illustrations: 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Garber, Eric A. E.
AU - Eppley, Robert M.
AU - Stack, Michael E.
AU - McLaughlin, Michael A.
AU - Park, Douglas L.
T1 - Feasibility of Immunodiagnostic Devices for the Detection of Ricin, Amanitin, and T-2 Toxin in Food.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/06//
VL - 68
IS - 6
M3 - Article
SP - 1294
EP - 1301
SN - 0362028X
AB - Qualitative and quantitative comparisons were conducted of commercially available immunodiagnostic devices for the detection of three select agents with oral LDࡐ values ≥0.1 mg/kg of body weight. Ricin (oral LDࡐ > 1 mg/kg), amanitin (oral LDࡐ approximately 0.1 mg/kg), and T-2 toxin (oral LDࡐ > 1 mg/kg) were spiked into beverages, produce, dairy, and baked goods and assayed using commercially available enzyme-linked immunosorbent assays (ELISAs) and lateral flow devices. In all cases, the commercial diagnostic kits successfully detected all three select agents at concentrations below what might be a health concern. The considerable difference between the limit of detection of the immunodiagnostic devices employed (typically ≤0.020 μg/g) and the amour of the select agent necessary to pose a health threat in a single serving of food facilitated the design of protocols for the high throughput screening of food samples. These protocols entailed simple extraction methods followed by sample dilution. Lateral flow devices and sandwich ELISAs for the detection of ricin had no significant background problems due to the food matrices. Competitive ELISAs, which typically have unacceptably high background reactions with food samples, successfully detected amanitin and T-2 toxin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ricin
KW - Plant toxins
KW - Amanitins
KW - Immunodiagnosis -- Equipment & supplies
KW - Immunodiagnosis
KW - Enzyme-linked immunosorbent assay
N1 - Accession Number: 17305911; Garber, Eric A. E. 1; Email Address: egarber@cfsan.fda.gov; Eppley, Robert M. 1; Stack, Michael E. 1; McLaughlin, Michael A. 1; Park, Douglas L. 1; Affiliations: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, Division of Natural Products, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Jun2005, Vol. 68 Issue 6, p1294; Thesaurus Term: Ricin; Thesaurus Term: Plant toxins; Subject Term: Amanitins; Subject Term: Immunodiagnosis -- Equipment & supplies; Subject Term: Immunodiagnosis; Subject Term: Enzyme-linked immunosorbent assay; Number of Pages: 8p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tadokoro, Taketsugu
AU - Yamaguchi, Yuji
AU - Batzer, Jan
AU - Coelho, Sergio G.
AU - Zmudzka, Barbara Z.
AU - Miller, Sharon A.
AU - Wolber, Rainer
AU - Beer, Janusz Z.
AU - Hearing, Vincent J.
T1 - Mechanisms of Skin Tanning in Different Racial/Ethnic Groups in Response to Ultraviolet Radiation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2005/06//
VL - 124
IS - 6
M3 - Article
SP - 1326
EP - 1332
SN - 0022202X
AB - Ultraviolet radiation stimulates pigmentation in human skin, but the mechanism(s) whereby this increase in melanin production (commonly known as tanning) occurs is not well understood. Few studies have examined the molecular consequences of UV on human skin of various racial backgrounds in situ. We investigated the effects of UV on human skin of various races before and at different times after a single 1 minimal erythemal dose UV exposure. We measured the distribution of DNA damage that results, as well as the melanin content/distribution and the expression of various melanocyte-specific genes. The density of melanocytes at the epidermal:dermal junction in different types of human skin are remarkably similar and do not change significantly within 1 wk after UV exposure. The expression of melanocyte-specific proteins (including TYR (tyrosinase), TYRP1 (tyrosinase-related protein 1), DCT (tyrosinase-related protein 2), MART1 (melanoma antigens recognized by T-cells) gp100 (Pmel17/silver), and MITF (micropthalmia transcription factor)) increased from 0 to 7 d after UV exposure, but the melanin content of the skin increased only slightly. The most significant change, however, was a change in the distribution of melanin from the lower layer upwards to the middle layer of the skin, which was more dramatic in the darker skin. These results provide a basis for understanding the origin of different skin colors and responses to UV within different races. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - HUMAN skin color
KW - MELANINS
KW - DNA damage
KW - GENES
KW - MELANOMA
KW - melanocyte
KW - melanosome
KW - photoprotection
KW - pigmentation
KW - ultraviolet
N1 - Accession Number: 17235692; Tadokoro, Taketsugu 1 Yamaguchi, Yuji 1 Batzer, Jan 2 Coelho, Sergio G. 3 Zmudzka, Barbara Z. 3 Miller, Sharon A. 3 Wolber, Rainer 2 Beer, Janusz Z. 3 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 2: R&D, Skin Research, Beiersdorf AG, Hamburg, Germany 3: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jun2005, Vol. 124 Issue 6, p1326; Subject Term: ULTRAVIOLET radiation; Subject Term: HUMAN skin color; Subject Term: MELANINS; Subject Term: DNA damage; Subject Term: GENES; Subject Term: MELANOMA; Author-Supplied Keyword: melanocyte; Author-Supplied Keyword: melanosome; Author-Supplied Keyword: photoprotection; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: ultraviolet; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.0022-202X.2005.23760.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilkes, Jon G.
AU - Rushing, Larry
AU - Nayak, Rajesh
AU - Buzatu, Dan A.
AU - Sutherland, John B.
T1 - Rapid phenotypic characterization of Salmonella enterica strains by pyrolysis metastable atom bombardment mass spectrometry with multivariate statistical and artificial neural network pattern recognition
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2005/06//
VL - 61
IS - 3
M3 - Article
SP - 321
EP - 334
SN - 01677012
AB - Abstract: Pyrolysis mass spectrometry was investigated for rapid characterization of bacteria. Spectra of Salmonella were compared to their serovars, pulsed-field gel electrophoresis (PFGE) patterns, antibiotic resistance profiles, and MIC values. Pyrolysis mass spectra generated via metastable atom bombardment were analyzed by multivariate principal component-discriminant analysis and artificial neural networks (ANNs). Spectral patterns developed by discriminant analysis and tested with Leave-One-Out (LOO) cross-validation distinguished Salmonella strains by serovar (97% correct) and by PFGE groups (49%). An ANN model of the same PFGE groups was cross-validated, using the LOO rule, with 92% agreement. Using an ANN, thirty previously unseen spectra were correctly classified by serotype (97%) and at the PFGE level (67%). Attempts by ANN to model spectra grouped by resistance profile-but ignoring PFGE or serotype-failed (10% correct), but ANNs differentiating ten samples of the same serotype/PFGE class were more successful. To assess the information content of PyMS data serendipitously associated with or directly related to resistance character, the ten isolates were grouped into four, three, or two categories. The four categories corresponded to four resistance profiles. The four class and three class ANNs showed much improved but insufficient modeling power. The two-class ANN and a corresponding multivariate model maximized inferential power for a coarse antibiotic-resistance-related distinction. They each cross-validated by LOO at 90%. This is the first direct correlation of pyrolysis metastable atom bombardment mass spectrometry with immunological (e.g. serology) or molecular biology (e.g. PFGE) based techniques. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - CHEMICAL reactions
KW - PATTERN perception
KW - GEL electrophoresis
KW - ANN
KW - MAB
KW - PyMS
KW - Salmonella
N1 - Accession Number: 17514495; Wilkes, Jon G.; Email Address: jwilkes@nctr.fda.gov Rushing, Larry 1 Nayak, Rajesh 1 Buzatu, Dan A. 1 Sutherland, John B. 1; Affiliation: 1: National Center for Toxicological Research, FDA, 3900 NCTR Drive, Jefferson, AR 72079, United States; Source Info: Jun2005, Vol. 61 Issue 3, p321; Subject Term: ENTEROBACTERIACEAE; Subject Term: CHEMICAL reactions; Subject Term: PATTERN perception; Subject Term: GEL electrophoresis; Author-Supplied Keyword: ANN; Author-Supplied Keyword: MAB; Author-Supplied Keyword: PyMS; Author-Supplied Keyword: Salmonella; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mimet.2004.12.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17514495&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feetham, Suzanne
AU - Thomson, Elizabeth J.
AU - Hinshaw, Ada Sue
T1 - Nursing Leadership in Genomics for Health and Society.
JO - Journal of Nursing Scholarship
JF - Journal of Nursing Scholarship
Y1 - 2005///2005 2nd Quarter
VL - 37
IS - 2
M3 - Article
SP - 102
EP - 110
PB - Wiley-Blackwell
SN - 15276546
AB - Purpose: This article is part of the series regarding genomics and nursing practice, science, education, and policy. Issues in genetic testing, genetic information and the lessons learned through applications of genetic and genomic science are analyzed and discussed.Framework: Scientists, scholars, and members of the public have articulated a vision to guide genomics research and scholarship. The three overarching themes of this conceptual framework are genomes to biology, genomes to health, and genomes to society.Conclusions: Nurses can promote the use of genomic research technologies and information in the context of health, biology, and society, as well as in nursing research, practice, education, and policy.Journal of Nursing Scholarship, 2005; 37:2, 102-110.© 2005Sigma Theta Tau International. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nursing Scholarship is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENOMICS
KW - GENETICS
KW - NURSING
KW - LEADERSHIP
KW - EDUCATION
KW - education
KW - genetics
KW - genomics
KW - health
KW - leadership
KW - nursing
KW - practice
KW - research
N1 - Accession Number: 16977253; Feetham, Suzanne 1; Email Address: sfeetham@hrsa.gov Thomson, Elizabeth J. 2 Hinshaw, Ada Sue 3; Affiliation: 1: Director, Center for Quality, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD 2: Program Director, NHGRI, National Institutes of Health, Bethesda 3: Dean and Professor, University of Michigan School of Nursing, Ann Arbor, MI; Source Info: 2005 2nd Quarter, Vol. 37 Issue 2, p102; Subject Term: GENOMICS; Subject Term: GENETICS; Subject Term: NURSING; Subject Term: LEADERSHIP; Subject Term: EDUCATION; Author-Supplied Keyword: education; Author-Supplied Keyword: genetics; Author-Supplied Keyword: genomics; Author-Supplied Keyword: health; Author-Supplied Keyword: leadership; Author-Supplied Keyword: nursing; Author-Supplied Keyword: practice; Author-Supplied Keyword: research; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1547-5069.2005.00021.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106487837
T1 - Nursing leadership in genomics for health and society.
AU - Feetham S
AU - Thomson EJ
AU - Hinshaw AS
Y1 - 2005///2005 2nd Quarter
N1 - Accession Number: 106487837. Language: English. Entry Date: 20050722. Revision Date: 20150819. Publication Type: Journal Article. Supplement Title: 2005 2nd Quarter. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 100911591.
KW - Genetics
KW - Genome, Human
KW - Health
KW - Hereditary Diseases
KW - Cystic Fibrosis
KW - Genetic Screening
KW - Health Policy
KW - Human Genome Project
KW - Leadership
KW - Mutation
KW - Neoplasms -- Familial and Genetic
KW - Nursing Role
KW - Research, Nursing
SP - 102
EP - 110
JO - Journal of Nursing Scholarship
JF - Journal of Nursing Scholarship
JA - J NURS SCHOLARSH
VL - 37
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Purpose: This article is part of the series regarding genomics and nursing practice, science, education, and policy. Issues in genetic testing, genetic information and the lessons learned through applications of genetic and genomic science are analyzed and discussed.Framework: Scientists, scholars, and members of the public have articulated a vision to guide genomics research and scholarship. The three overarching themes of this conceptual framework are genomes to biology, genomes to health, and genomes to society.Conclusions: Nurses can promote the use of genomic research technologies and information in the context of health, biology, and society, as well as in nursing research, practice, education, and policy.
SN - 1527-6546
AD - Lambda, Director, Center for Quality, Health Resources and Services Administration, Department of Health and Human Services, 17 C 26 Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857; sfeetham@hrsa.gov
U2 - PMID: 15960053.
DO - 10.1111/j.1547-5069.2005.00021.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106487837&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Harper, Martin
T1 - ASTM International Standards for Monitoring Chemical Hazards in Workplaces.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2005/06//
VL - 2
IS - 6
M3 - Article
SP - D44
EP - D47
SN - 15459624
AB - The article presents information on international standards for monitoring chemical hazards in workplaces. The health of workers in many industries is at risk through occupational exposure to toxic substances. To estimate workers' exposures, occupational contact with hazardous materials at the job site is typically monitored by sampling and analyzing workplace atmospheres. This is because in occupational settings, inhalation is ordinarily the most likely route of entry of hazardous substances into the body. Dermal contact and ingestion are other potential routes of occupational exposure to chemical agents. Hence, in addition to methods for workplace air monitoring, procedures for measuring surface contaminants in the workplace are also needed.
KW - WORK environment
KW - INDUSTRIAL safety
KW - INGESTION
KW - HAZARDOUS wastes
KW - POISONS
KW - POLLUTANTS
N1 - Accession Number: 16970558; Ashley, Kevin 1 Harper, Martin 2; Affiliation: 1: U. S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: U. S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Jun2005, Vol. 2 Issue 6, pD44; Subject Term: WORK environment; Subject Term: INDUSTRIAL safety; Subject Term: INGESTION; Subject Term: HAZARDOUS wastes; Subject Term: POISONS; Subject Term: POLLUTANTS; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/15459620590949093
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106478329
T1 - Analytical performance criteria: ASTM International Standards for Monitoring Chemical Hazards in Workplaces...American Society for Testing and Materials
AU - Ashley K
AU - Harper M
Y1 - 2005/06//
N1 - Accession Number: 106478329. Language: English. Entry Date: 20050708. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Occupational Hazards -- Prevention and Control
KW - Poisoning
KW - Occupational Exposure -- Standards
SP - D44
EP - 7
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16020085.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106478329&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schulte, Paul A.
T1 - Characterizing the Burden of Occupational Injury and Disease.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2005/06//
VL - 47
IS - 6
M3 - Article
SP - 607
EP - 622
SN - 10762752
AB - Objectives: To review the literature on the burden of occupational disease and injury and to provide a comprehensive characterization of the burden. Methods: The scientific and governmental literature from 1990 to the present was searched and evaluated. Thirty-eight studies illustrative of the burden of occupational disease were reviewed for findings, methodology, strengths, and limitations. Results: Recent U.S. estimates of occupational mortality and morbidity include approximately 55,000 deaths (eighth leading cause) and 18 million disabling injuries per year, respectively. Comprehensive estimates of U S. costs related to these burdens range between $128 billion and $155 billion per year. Despite these significant indicators, occupational morbidity, mortality, and risks are not well characterized in comparative burden assessments. Conclusions: The magnitude of occupational disease and injury burden is significant but underestimated. There is a need for an integrated approach to address these underestimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - WOUNDS & injuries
KW - OCCUPATIONAL mortality
KW - OCCUPATIONAL diseases
KW - RESEARCH
KW - UNITED States
N1 - Accession Number: 17393752; Schulte, Paul A. 1; Email Address: pas4@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.; Source Info: Jun2005, Vol. 47 Issue 6, p607; Subject Term: WORK-related injuries; Subject Term: WOUNDS & injuries; Subject Term: OCCUPATIONAL mortality; Subject Term: OCCUPATIONAL diseases; Subject Term: RESEARCH; Subject Term: UNITED States; Number of Pages: 16p; Document Type: Article
L3 - 10.1097/01 .jom.0000165086.25595.9d
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17393752&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 109848976
T1 - An ongoing discussion with the readers of the Journal of Patient Safety.
AU - Clancy CM
Y1 - 2005/06//2005 Jun
N1 - Accession Number: 109848976. Language: English. Entry Date: 20080425. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Quality of Health Care -- Trends
KW - United States Agency for Healthcare Research and Quality
KW - Employee Attitudes
KW - Fatigue
KW - Interns and Residents
KW - Organizational Culture
KW - Personnel Staffing and Scheduling
KW - Research Priorities
KW - Surveys
KW - Voluntary Reporting
SP - 76
EP - 77
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 1
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Director, Agency for Healthcare Research and Quality
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chasnoff, Ira J.
AU - McGourty, Richard F.
AU - Bailey, Gregory W.
AU - Hutchins, Ellen
AU - Lightfoot, Saundra O.
AU - Pawson, Leslie Lynn
AU - Fahey, Cynthia
AU - May, Barbara
AU - Brodie, Paula
AU - McCulley, Larry
AU - Campbell, Jan
T1 - The 4P's Plus© Screen for Substance Use in Pregnancy: Clinical Application and Outcomes.
JO - Journal of Perinatology
JF - Journal of Perinatology
Y1 - 2005/06//
VL - 25
IS - 6
M3 - Article
SP - 368
EP - 374
SN - 07438346
AB - OBJECTIVE:Determine the prevalence of substance use among pregnant women in five diverse communities utilizing the 4P's Plus© screen for alcohol, tobacco, and other drug use.STUDY DESIGN:Pregnant women enrolled in prenatal care clinics in five communities were screened for substance use with the 4P's Plus©. Those women with a positive screen underwent an assessment for substance use through a follow-up structured clinical interview conducted at the same prenatal visit.RESULTS:Among 7818 women in five communities, 2555 (32.7%) had a positive screen for substance use in pregnancy. Four of the communities conducted a follow-up assessment on all women with a positive screen (n=1548). Among these women, 717 (15%of the total population) had continued use after learning of the pregnancy. Overall, 21%of the pregnant women used alcohol prior to recognition of the pregnancy, and 11%continued use after knowledge of the pregnancy. Among the 512 women who continued to use alcohol, 2%were drinking daily, 7%were drinking 3 to 6 days per week, 27%were drinking 1 to 2 days per week, and 63%were drinking less than 1 day per week. The rates of marijuana use and other illicit drug use among the women were 7 and 2%, respectively, prior to knowledge of pregnancy and dropped to 3 and 1%after learning of the pregnancy.CONCLUSION:The 4P's Plus© identifies not only those pregnant women whose drinking or drug use is at a high enough level to impair daily functioning, but provides an opportunity for early intervention for the much larger group of women whose pregnancies are at risk from relatively small amounts of substance use.Journal of Perinatology (2005) 25, 368-374. doi:10.1038/sj.jp.7211266 Published online 10 February 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Perinatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANT women
KW - PRENATAL care
KW - NUTRITION in pregnancy
KW - PREGNANCY
KW - MEDICAL care
KW - PERINATOLOGY
N1 - Accession Number: 17134026; Chasnoff, Ira J. 1 McGourty, Richard F. 1 Bailey, Gregory W. 1 Hutchins, Ellen 2 Lightfoot, Saundra O. 3 Pawson, Leslie Lynn 4 Fahey, Cynthia 5 May, Barbara 6 Brodie, Paula 7 McCulley, Larry 7 Campbell, Jan 8; Affiliation: 1: Children's Research Triangle Chicago, IL, USA 2: Maternal Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Washington, DC, USA 3: University of Chicago Comer Children's Hospital, Chicago, IL, USA 4: Ventura County Medical Center, Ventura, CA, USA 5: Ventura County Public Health, Ventura, CA, USA 6: Southern New Jersey Perinatal Coalition, Camden, NJ, USA 7: Southern Illinois Healthcare Foundation, East St. Louis, IL, USA 8: San Luis Obispo County Public Health Department, Family Health Services Division, San Luis Obispo, CA, USA; Source Info: Jun2005, Vol. 25 Issue 6, p368; Subject Term: PREGNANT women; Subject Term: PRENATAL care; Subject Term: NUTRITION in pregnancy; Subject Term: PREGNANCY; Subject Term: MEDICAL care; Subject Term: PERINATOLOGY; Number of Pages: 7p; Document Type: Article
L3 - 10.1038/sj.jp.7211266
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murashov
AU - V. V.
AU - Demchuk
AU - E.
T1 - A Comparative Study of Unrelaxed Surfaces on Quartz and Kaolinite, Using the Periodic Density Functional Theory.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2005/06//
VL - 109
IS - 21
M3 - Article
SP - 10835
EP - 10841
SN - 15206106
AB - To investigate surface properties of fractured silica particles, which are commonly connected to the etiology of silica toxicity, models of low-index unrelaxed surfaces of quartz and kaolinite were constructed and analyzed using the periodic density functional theory calculations. The models were used to investigate surface sites that emerge in the processes of heterolytic and homolytic cleavage of quartz. It is found that the quartz surface is stabilized by two types of interactions. One, due to a more even charge distribution of sites, was characterized by surface energies of up to 0.025 eV·Å-2 and the other, due to a more even oxygen distribution between complementary surfaces, was up to 0.036 eV·Å-2. The total specific surface energies of unrelaxed surfaces ranged from 0.161 to 0.200 eV·Å-2 for quartz and from 0.017 to 0.158 eV·Å-2 for kaolinite. For the conchoidal fracture of quartz an average specific surface energy of 0.187 eV·Å-2 was obtained. These results provide a foundation for further characterization of the surface properties of mechanically comminuted respirable silica particulate and for reduction of occupational health hazards due to pulverized silica. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDE minerals
KW - SILICON
KW - SURFACE chemistry
KW - MATTER -- Properties
N1 - Accession Number: 20142809; Murashov V. V. 1 Demchuk E. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Source Info: Jun2005, Vol. 109 Issue 21, p10835; Subject Term: OXIDE minerals; Subject Term: SILICON; Subject Term: SURFACE chemistry; Subject Term: MATTER -- Properties; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ivanov, Alexander
AU - Dragunsky, Eugenia
AU - Ivanova, Olga
AU - Rezapkin, Gennady
AU - Potapova, Svetlana
AU - Chumakov, Konstantin
T1 - Determination of poliovirus-specific IgA in saliva by ELISA tests
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2005/06//
VL - 126
IS - 1/2
M3 - Article
SP - 45
EP - 52
SN - 01660934
AB - Abstract: This study describes three ELISA methods for detection of immunoglobulin A (IgA) specific to three types of Sabin strains of poliovirus in saliva taken from 70 children aged 6–7 years vaccinated with a full course of oral poliovirus vaccine (OPV). Of the three ELISA methods (conventional IgA ELISA and two new methods described in this communication, the α-capture ELISA and Inhibition ELISA), α-capture ELISA demonstrated the highest sensitivity, with all saliva samples testing positive for Sabin poliovirus strains specific IgA antibodies of 1–3 types. Of 62 available α-capture ELISA positive saliva samples, all were also positive by the inhibition ELISA, and a significant correlation was found between the results. Fifty-two available saliva samples were screened by the three ELISA tests with positive results, and a significant correlation was found between the α-capture ELISA and the IgA ELISA; the correlation between the IgA ELISA and inhibition ELISA was not significant. The results of this study suggest that determination of Sabin poliovirus-specific IgA in human saliva by the ELISA techniques (especially by the novel α-capture ELISA) can be used reliably for evaluation of mucosal immunity in large groups of people immunized with poliovirus vaccines and for epidemiological studies. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - POLIOVIRUS
KW - IMMUNIZATION of children
KW - IMMUNOGLOBULINS
KW - α-Capture technique
KW - ELISA
KW - IgA
KW - OPV
KW - Poliovirus
KW - Saliva
N1 - Accession Number: 17673306; Ivanov, Alexander 1; Email Address: ivanov@cber.fda.gov Dragunsky, Eugenia 1 Ivanova, Olga 2 Rezapkin, Gennady 1 Potapova, Svetlana 1 Chumakov, Konstantin 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-470, NLRC/B-121, 1401 Rockville Pike, Rockville, MD 20852, USA 2: M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, Moscow 142782, Russia; Source Info: Jun2005, Vol. 126 Issue 1/2, p45; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: POLIOVIRUS; Subject Term: IMMUNIZATION of children; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: α-Capture technique; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: IgA; Author-Supplied Keyword: OPV; Author-Supplied Keyword: Poliovirus; Author-Supplied Keyword: Saliva; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jviromet.2005.01.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khurana, Surender
AU - Kennedy, Michael
AU - King, Lisa R.
AU - Golding, Hana
T1 - Identification of a Linear Peptide Recognized by Monoclonal Antibody 2D7 Capable of Generating CCR5-Specific Antibodies with Human Immunodeficiency Virus-Neutralizing Activity.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/06//
VL - 79
IS - 11
M3 - Article
SP - 6791
EP - 6800
SN - 0022538X
AB - CCR5 is the major coreceptor for human immunodeficiency virus (HIV) infection. The murine monoclonal antibody (MAb) 2D7, which recognizes a conformation-dependent epitope in the second extracellular loop of CCR5, is one of the most potent inhibitors of R5 virus cell entry. However, attempts to humanize 2D7 for in vivo human use have been unsuccessful so far. A filamentous phage library expressing random peptides was used to identify a peptide mimitope that is recognized by MAb 2D7. A synthetic peptide containing this sequence (2D7-2SK) bound to MAb 2D7 with high affinity and reversed its HIV type 1 (HIV-1) fusion inhibitory activity. The peptide contains sequence homologies to two distal regions of the second extracellular loop of human CCR5, both of which are required for MAb 2D7 binding. Rabbit anti-2D7-mimitope antibodies competed with MAb 2D7 for binding to the 2D7-2SK peptide in Biacore biosensor testing. Importantly, the rabbit anti-2D7-2SK antibodies bound to CCR5 on cells and specifically inhibited R5 (but not X4) envelope-mediated syncytium formation. These antibodies also neutralized infection of human peripheral blood mononuclear cells with R5 HIV isolates comparably to MAb 2D7. In summary, we have identified a novel peptide that closely mimics the MAb 2D7 epitope on CCR5. This peptide could be included as a potential vaccine candidate or to isolate 2D7-like human antibodies as entry inhibitors for R5 viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - MONOCLONAL antibodies
KW - PEPTIDES
KW - VACCINES
KW - RABBITS as laboratory animals
N1 - Accession Number: 17175801; Khurana, Surender 1 Kennedy, Michael 2 King, Lisa R. 1 Golding, Hana 1; Email Address: goldingh@cber.FDA.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland 20892 2: Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Jun2005, Vol. 79 Issue 11, p6791; Subject Term: HIV (Viruses); Subject Term: MONOCLONAL antibodies; Subject Term: PEPTIDES; Subject Term: VACCINES; Subject Term: RABBITS as laboratory animals; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 1 Chart, 16 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.11.6791-6800.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miles, Lesa R.
AU - Agresta, Beth E.
AU - Khan, Mahfuz B.
AU - Tang, Shixing
AU - Levin, Judith G.
AU - Powell, Michael D.
T1 - Effect of Polypurine Tract (PPT) Mutations on Human Immunodeficiency Virus Type 1 Replication: a Virus with a Completely Randomized PPT Retains Low Infectivity.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/06//
VL - 79
IS - 11
M3 - Article
SP - 6859
EP - 6867
SN - 0022538X
AB - We introduced polypurine tract (PPT) mutations, which we had previously tested in an in vitro assay, into the viral clone NL4-3KFSΔ nef. Each mutant was tested for single-round infectivity and virion production. All of the PPT mutations had an effect on replication; however, mutation of the 5' end appeared to have less of an effect on infectivity than mutation of the 3' end of the PPT sequence. Curiously, a mutation in which the entire PPT sequence was randomized (PPTSUB) retained 12% of the infectivity of the wild type (WT) in a multinuclear activation of galactosidase indicator assay. Supernatants from these infections contained viral particles, as evidenced by the presence of p24 antigen. Two-long terminal repeat (2-LTR) circle junction analysis following PPTSUB infection revealed that the mutant could form a high percentage of normal junctions. Quantification of the 2-LTR circles using real-time PCR revealed that number of 2-LTR circles from cells infected with the PPTSUB mutant was 3.5 logs greater than 2-LTR circles from cells infected with WT virus. To determine whether the progeny virions from a PPTSUB infection could undergo further rounds of replication, we introduced the PPTSUB mutation into a replication-competent virus. Our results show that the mutant virus is able to replicate and that the infectivity of the progeny virions increases with each passage, quickly reverting to a WT PPT sequence. Together, these experiments confirm that the 3' end of the PPT is important for plus-strand priming and that a virus that completely lacks a PPT can replicate at a low level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL replication
KW - POLYMERASE chain reaction
KW - HIV (Viruses)
KW - MUTATION (Biology)
KW - ANTIGENS
N1 - Accession Number: 17175808; Miles, Lesa R. 1 Agresta, Beth E. 2 Khan, Mahfuz B. 1 Tang, Shixing 3 Levin, Judith G. 2 Powell, Michael D. 1; Email Address: powellm@msm.edu; Affiliation: 1: Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310 2: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 3: Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; Source Info: Jun2005, Vol. 79 Issue 11, p6859; Subject Term: VIRAL replication; Subject Term: POLYMERASE chain reaction; Subject Term: HIV (Viruses); Subject Term: MUTATION (Biology); Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 3 Diagrams, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.11.6859-6867.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106519702
T1 - Health-related barriers to employment among people with HIV/AIDS.
AU - Razzano LA
AU - Hamilton MM
Y1 - 2005/06//
N1 - Accession Number: 106519702. Language: English. Entry Date: 20050930. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Beck Depression Inventory (BDI); MOS-HIV Health Survey (MOS-HIV). Grant Information: Funded under the Field-Initiated Research Grant Program, No. H133G010093, United States Department of Education, National Institute on Disability and Rehabilitation Research. NLM UID: 9200437.
KW - HIV-Infected Patients
KW - Employment of Disabled
KW - Illinois
KW - Clinical Assessment Tools
KW - Psychological Tests
KW - Comparative Studies
KW - Chi Square Test
KW - Interviews
KW - One-Way Analysis of Variance
KW - Female
KW - Male
KW - Funding Source
KW - Human
SP - 179
EP - 188
JO - Journal of Vocational Rehabilitation
JF - Journal of Vocational Rehabilitation
JA - J VOCAT REHABIL
VL - 22
IS - 3
PB - IOS Press
AB - With the advent of more advanced treatments and therapies, people with HIV/AIDS are experiencing significant improvements in physical and mental health, making many of their ongoing career goals more realistic. However, many people with HIV/AIDS who are unemployed but would like to work continue to have major concerns regarding the impact of employment on their benefits and entitlements. In addition to issues regarding potential financial hardships, many people living with HIV/AIDS express uncertainty related to their health status, and they worry that some working conditions could deleteriously affect their health. The present evaluation focuses on two major issues identified in previous research: health perceptions and sources of insurance and health benefits. In addition, the study utilizes a standardized instrument, the MOS-HIV Scale, designed specifically to characterize aspects of health and well-being among people with HIV/AIDS.
SN - 1052-2263
AD - Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 104 S. Michigan Avenue, Suite 900, Chicago, IL 60603; razzano@psych.uic.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nayak, Rajesh
AU - Stewart, Tabitha M.
AU - Nawaz, Mohamed S.
T1 - PCR identification of Campylobacter coli and Campylobacter jejuni by partial sequencing of virulence genes
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2005/06//
VL - 19
IS - 3
M3 - Article
SP - 187
EP - 193
SN - 08908508
AB - Abstract: The objective of this study was to utilize a multiplex PCR assay for concurrent detection of Campylobacter spp. and C. coli or C. jejuni, using probes derived from genes cadF and ceuE and an undefined virulence gene. A total of 97 Campylobacter strains, isolated from turkey litter (n=74), chicken livers (n=15) and clinical (n=8) samples, were speciated using the PCR-based assay. PCR amplification of the isolates identified a 400-bp cadF gene, conserved in Campylobacter species, an 894-bp ceuE gene, specific for C. coli, and a 160-bp oxidoreductase gene, specific for C. jejuni. The ∼35kDa cadF adhesion proteins allow Campylobacter to bind to the intestinal epithelial cells and the 37kDa ceuE lipoproteins are involved in siderophore transport. Sequencing of the 160-bp undefined gene yielded a 67% protein identical match with a gene encoding an oxidoreductase subunit in C. jejuni. The specificity of the assay was validated on 36 non-Campylobacter strains (11 Gram-positive and 25 Gram-negative bacteria). The PCR assay identified 59% of turkey and 47% of chicken isolates as C. jejuni, and 41% of turkey and 53% of chicken isolates as C. coli. All human isolates were identified as C. jejuni. The specificity of this assay to detect C. coli or C. jejuni was 97%. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER jejuni
KW - GRAM-negative bacteria
KW - HEREDITY
KW - EPITHELIAL cells
KW - Campylobacter spp.
KW - Multiplex PCR
KW - Virulence genes
N1 - Accession Number: 17613951; Nayak, Rajesh; Email Address: rnayak@nctr.fda.gov Stewart, Tabitha M. Nawaz, Mohamed S. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jun2005, Vol. 19 Issue 3, p187; Subject Term: CAMPYLOBACTER jejuni; Subject Term: GRAM-negative bacteria; Subject Term: HEREDITY; Subject Term: EPITHELIAL cells; Author-Supplied Keyword: Campylobacter spp.; Author-Supplied Keyword: Multiplex PCR; Author-Supplied Keyword: Virulence genes; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mcp.2004.11.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Sheng
AU - Zhao, Shaohua
AU - McDermott, Patrick F.
AU - Schroeder, Carl M.
AU - White, David G.
AU - Meng, Jianghong
T1 - A DNA microarray for identification of virulence and antimicrobial resistance genes in Salmonella serovars and Escherichia coli
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2005/06//
VL - 19
IS - 3
M3 - Article
SP - 195
EP - 201
SN - 08908508
AB - Abstract: Characterization of antimicrobial resistance and virulence gene profiles provides important information on the potential pathogenicity of bacteria. This information can be used to facilitate prompt and effective treatment of bacterial infections. We developed and tested a PCR-based microarray platform for detecting virulence and antimicrobial resistance genes in Salmonella serovars and Escherichia coli. Twelve Salmonella and seven E. coli isolates were screened for the presence of 25 virulence and 23 antimicrobial resistance genes. All S. Typhimurium DT104 isolates harbored virulence plasmids. E. coli O157:H7 isolates possessed virulence genes typical of enterohemorrhagic E. coli (EHEC), whereas E. coli O126 isolates contained virulence genes characteristic of enteropathogenic E. coli (EPEC) and E. coli O111, O78 and O147 isolates had virulence genes characteristic of enterotoxigenic E. coli (ETEC). Correlation between antimicrobial resistance phenotype and genotype was observed for each isolate. The aadA, tetA, and sulI genes were most commonly detected in bacteria resistant to streptomycin, tetracycline and sulfonamide, respectively. All isolates exhibiting resistance to third generation cephalosporins harbored the bla CMY-2 and bla TEM-1 genes. Microarray analysis is an effective method to rapidly screen Salmonella and E. coli for multiple antimicrobial resistance and virulence genes. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRULENCE (Microbiology)
KW - ESCHERICHIA coli
KW - SALMONELLA
KW - GENES
KW - CEPHALOSPORINS
KW - Antimicrobial resistance
KW - DNA microarray
KW - E. coli
KW - Salmonella
KW - Virulence
N1 - Accession Number: 17613952; Chen, Sheng 1 Zhao, Shaohua 2 McDermott, Patrick F. 2 Schroeder, Carl M. 1 White, David G. 2 Meng, Jianghong 1; Email Address: jmeng@umd.edu; Affiliation: 1: Department of Nutrition and Food Science, University of Maryland, 0112 Skinner Building, College Park, MD 20742, USA 2: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD, USA; Source Info: Jun2005, Vol. 19 Issue 3, p195; Subject Term: VIRULENCE (Microbiology); Subject Term: ESCHERICHIA coli; Subject Term: SALMONELLA; Subject Term: GENES; Subject Term: CEPHALOSPORINS; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: E. coli; Author-Supplied Keyword: Salmonella; Author-Supplied Keyword: Virulence; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mcp.2004.11.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106501669
T1 - Why is an infection control program needed in the hemodialysis setting?
AU - Arduino MJ
AU - Tokars JI
Y1 - 2005/06//2005 Jun
N1 - Accession Number: 106501669. Language: English. Entry Date: 20050819. Revision Date: 20150818. Publication Type: Journal Article; practice guidelines; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8709753.
KW - Bacterial Infections -- Prevention and Control
KW - Catheter Care -- Standards
KW - Catheter-Related Infections -- Prevention and Control
KW - Dialysis Centers -- Administration
KW - Hemodialysis -- Adverse Effects
KW - Infection Control
KW - Infection Control -- Standards
KW - Bacteremia -- Epidemiology
KW - Bacterial Colonization
KW - Bacterial Contamination
KW - Centers for Disease Control and Prevention (U.S.)
KW - Kidney Failure, Chronic -- Therapy
KW - Sepsis
KW - Vancomycin Resistance
SP - 44
EP - 49
JO - Nephrology News & Issues
JF - Nephrology News & Issues
JA - NEPHROL NEWS ISSUES
VL - 19
IS - 7
CY - Birmingham, Alabama
PB - Grand View Media Group
AB - Infections account for the second leading cause of mortality among patients with end-stage renal disease. Many of these infections are due to sepsis, primarily arising from the vascular access site. Septicemia alone accounts for almost 11% of mortality in hemodialysis patients. Hemodialysis patients are also a sentinel population for the emergence of antimicrobial resistance, especially with regards to gram positive cocci (vancomycin-resistant enterococci (VRE), methicillin resistant S. aureus (MRSA), Staphylococcus aureus with reduced susceptibility to vancomycin (VISA), and vancomycin resistant S. aureus [VRSAJ). It is extremely important to follow infection control recommendations designed to prevent these types of adverse events from occurring in the hemodialysis population. The campaign to prevent antimicrobial resistance in dialysis includes four strategies: Prevent infection; diagnose and treat infection; use antimicrobials wisely, and prevent transmission. In addition, efforts to prevent infection should include avoiding use of hemodialysis catheters, whenever possible, and meticulous care of hemodialysis catheters and other vascular access sites. These efforts would improve patient outcomes and quality-of--life issues by reducing hospitalizations and mortality due to infection and vascular access complications.
SN - 0896-1263
AD - Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Ga
U2 - PMID: 16008023.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106469396
T1 - FDA drug approval summary: pemetrexed for injection (ALIMTA) for the treatment of non-small cell lung cancer.
AU - Cohen MH
AU - Johnson JR
AU - Wang Y
AU - Sridhara R
AU - Pazdur R
Y1 - 2005/06//
N1 - Accession Number: 106469396. Language: English. Entry Date: 20060707. Revision Date: 20150711. Publication Type: Journal Article; CEU; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Lung Neoplasms -- Drug Therapy
KW - Pemetrexed -- Therapeutic Use
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Clinical Trials
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Female
KW - Human
KW - Kaplan-Meier Estimator
KW - Male
KW - Middle Age
KW - Survival
SP - 363
EP - 368
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 10
IS - 6
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On August 19, 2004, pemetrexed for injection (Alimta); Eli Lilly and Company, Indianapolis, IN, http://www.lilly.com) received accelerated approval as monotherapy for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who had received prior chemotherapy. Approval was primarily based on a single, controlled, unblinded trial. Five hundred seventy-one protocol-eligible patients were randomized to receive either pemetrexed or docetaxel (Taxotere); Aventis Pharmaceuticals Inc., Bridgewater, NJ, http://www.aventispharmaus.com). The primary efficacy end point was overall survival. The median survival times were 8.3 months in the pemetrexed arm and 7.9 months in the docetaxel arm. Neither superiority nor noninferiority for overall survival could be demonstrated, the latter because a reliable and consistent survival effect of docetaxel could not be estimated and because of significant crossover of pemetrexed-treated patients to docetaxel after tumor progression. Comparable response rates, 9.1% for pemetrexed and 8.8% for docetaxel, times to progressive disease, and progression-free survival times supported the conclusion that an effect of pemetrexed on survival was reasonably likely, however.In addition, pemetrexed was felt to have a more favorable safety profile than docetaxel. Of greatest importance, pemetrexed caused significantly less neutropenia, febrile neutropenia, neutropenic infections, and need for granulocyte/macrophage colony-stimulating factors.
SN - 1083-7159
AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD; cohenma@cder.fda.gov
U2 - PMID: 15967829.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dhanireddy, Kiran K.
AU - Maniscalco, Jennifer
AU - Kirk, Allan D.
T1 - Is tolerance induction the answer to adolescent non-adherence?
JO - Pediatric Transplantation
JF - Pediatric Transplantation
Y1 - 2005/06//
VL - 9
IS - 3
M3 - Article
SP - 357
EP - 363
PB - Wiley-Blackwell
SN - 13973142
AB - Dhanireddy KK, Maniscalco J, Kirk AD. Is tolerance induction the answer to adolescent non-adherence?Pediatr Transplantation 2005.© 2005 Blackwell MunksgaardBy definition, tolerance will eliminate the problem of adolescent medication non-adherence. Although adolescents’ propensity toward non-adherence makes them at first glance to be particularly attractive candidates for tolerance trials, there are also immunologic, psychosocial and ethical barriers that temper enthusiasm for their inclusion at present. Limits in emotional and cognitive maturity are combined during the teenage years with adult-like immunologic maturity to lessen the potential for successful implementation of tolerance and near tolerance strategies. Alternatively, an interval step to tolerance in adolescents is to eliminate the medications most likely contributing to non-adherence through harsh side effects such as steroids and calcineurin inhibitors. This manuscript will review the general topic of transplantation tolerance with specific attention given to the application of pro-tolerant therapies in adolescent recipients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATIENT refusal of treatment
KW - PATIENT compliance
KW - MEDICAL cooperation
KW - HEALTH behavior
KW - EMOTIONS (Psychology)
KW - COGNITION
KW - adolescent
KW - chimerism
KW - costimulation blockade
KW - lymphocyte depletion
KW - organ transplantation
KW - patient nonadherence
KW - transplantation tolerance
N1 - Accession Number: 17045620; Dhanireddy, Kiran K. 1,2 Maniscalco, Jennifer 3 Kirk, Allan D. 1; Email Address: allank@intra.niddk.nih.gov; Affiliation: 1: Transplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA 2: Department of Surgery, Georgetown University Medical Center, Washington, DC, USA 3: Department of Pediatrics, Children's National Medical Center, The George Washington University School of Medicine, Washington, DC, USA; Source Info: Jun2005, Vol. 9 Issue 3, p357; Subject Term: PATIENT refusal of treatment; Subject Term: PATIENT compliance; Subject Term: MEDICAL cooperation; Subject Term: HEALTH behavior; Subject Term: EMOTIONS (Psychology); Subject Term: COGNITION; Author-Supplied Keyword: adolescent; Author-Supplied Keyword: chimerism; Author-Supplied Keyword: costimulation blockade; Author-Supplied Keyword: lymphocyte depletion; Author-Supplied Keyword: organ transplantation; Author-Supplied Keyword: patient nonadherence; Author-Supplied Keyword: transplantation tolerance; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1399-3046.2005.00285.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lotstein, Debra S.
AU - McPherson, Merle
AU - Strickland, Bonnie
AU - Newacheck, Paul W.
T1 - Transition Planning for Youth With Special Health Care Needs: Results From the National Survey of Children With Special Health Care Needs.
JO - Pediatrics
JF - Pediatrics
Y1 - 2005/06//
VL - 115
IS - 6
M3 - Article
SP - 1562
EP - 1568
PB - American Academy of Pediatrics
SN - 00314005
AB - Objective. To describe the proportion of youth with special health care needs (YSHCN) who are receiving services for medical transitions and to describe which sociodemographic and health care--related factors are associated with receiving transition services. Methods. We analyzed responses to questions about medical transitions from the 2001 National Survey of Children With Special Health Care Needs (NS-CSHCN). Parents or guardians of youth aged 13 to 17 years who screened positive for the survey were asked (1) whether they had discussed with health care providers how their child's health care needs might change in adulthood, (2) if they had a plan to address these changing needs, and (3) if their child's health care providers had discussed having their child eventually see a doctor who treats adults. Bivariate and multivariate associations were estimated to identify sociodemographic and health care factors related to receiving medical-transition services. Results. Overall, 50% of respondents had discussed their child's changing health care needs with their physicians, although significantly fewer Hispanic youth compared with other youth reported these discussions. Youth who met criteria for a medical home were more likely to have discussed changing needs and to have a plan addressing these needs. Of those who had discussed changing needs, 59%had a plan to address these needs and ∼42% had reported discussing shifting care to adult-oriented providers. Younger teens and non-Hispanic black children were less likely to have discussed changing providers. Fifteen percent of YSHCN met the Maternal and Child Health Bureau's core outcome for medical transitions. A multivariate logistic-regression model found that older age and having a medical home were significantly associated with increased odds of meeting the outcome measure. Conclusion. The proportion of YSHCN meeting the medical-transition outcome measure is quite low, particularly for youth from ethnic... [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS
KW - YOUTH
KW - MEDICAL care
KW - CHILD health services
KW - CHILDREN -- Services for
KW - adolescents
KW - special needs
KW - transition to adulthood
N1 - Accession Number: 17188509; Lotstein, Debra S. 1,2; Email Address: dlotstein@mednet.ucla.edu McPherson, Merle 3 Strickland, Bonnie 3 Newacheck, Paul W. 4; Affiliation: 1: Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, California 2: Rand Health, Santa Monica, California 3: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 4: Institute for Health Policy Studies and Department of Pediatrics, University of California, San Francisco, California; Source Info: Jun2005, Vol. 115 Issue 6, p1562; Subject Term: TEENAGERS; Subject Term: YOUTH; Subject Term: MEDICAL care; Subject Term: CHILD health services; Subject Term: CHILDREN -- Services for; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: special needs; Author-Supplied Keyword: transition to adulthood; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1542/peds.2004-1262
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106546307
T1 - Employment outcomes in Massachusetts Clubhouses.
AU - McKay C
AU - Johnsen M
AU - Stein R
Y1 - 2005///Summer2005
N1 - Accession Number: 106546307. Language: English. Entry Date: 20051202. Revision Date: 20150820. Publication Type: Journal Article; research. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Massachusetts Clubhouse Coalition Employment Survey. NLM UID: 9601800.
KW - Employment
KW - Mental Disorders -- Rehabilitation
KW - Rehabilitation, Vocational
KW - Adult
KW - Analysis of Variance
KW - Chi Square Test
KW - Descriptive Statistics
KW - Female
KW - Formative Evaluation Research
KW - Male
KW - Mann-Whitney U Test
KW - Massachusetts
KW - Middle Age
KW - P-Value
KW - Prospective Studies
KW - Research Instruments
KW - Sample Size
KW - Surveys
KW - T-Tests
KW - Time Factors
KW - Treatment Outcomes
KW - Human
SP - 25
EP - 33
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 29
IS - 1
CY - Washington, District of Columbia
PB - American Psychological Association
AB - Employment outcomes of individuals participating in 17 Massachusetts Clubhouses certified by the International Center for Clubhouse Development were examined through an annual survey. Major components of employment programs in contemporary clubhouses are identified and individual employment outcomes are described. Within contemporary practice in ICCD clubhouses in this sample, clubhouses provided a three-pronged approach to employment. Between 1998-2001, 1702 individuals worked in 2714 separate job placements, employed in Transitional (TE), Supported (SE), and Independent Employment (IE). Forty percent of members with more than one job (N = 385) participated in at least one TE. Individuals with longer memberships tended to work longer and had higher job earnings.
SN - 1095-158X
AD - Research Instructor/Director, Center for Mental Health Services Research, University of Massachusetts Medical School; colleen.mckay@umassmed.edu
U2 - PMID: 16075694.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105070384
T1 - Commentary on 'understanding mass panic and other collective responses to threat and disaster': debunking the myth of panic.
AU - Norwood AE
Y1 - 2005///Summer2005
N1 - Accession Number: 105070384. Language: English. Entry Date: 20100820. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Mawson AR. Understanding mass panic and other collective responses to threat and disaster. (PSYCHIATRY INTERPERS BIOL PROCESS) Summer2005; 68 (2): 95-113. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376470.
KW - Behavior
KW - Disasters
KW - Fear
KW - Attachment Behavior
KW - Disaster Planning
KW - Social Behavior
SP - 114
EP - 114
JO - Psychiatry: Interpersonal & Biological Processes
JF - Psychiatry: Interpersonal & Biological Processes
JA - PSYCHIATRY INTERPERS BIOL PROCESS
VL - 68
IS - 2
CY - Oxfordshire,
PB - Routledge
SN - 0033-2747
AD - Office of Public Health Emergency Preparedness (Room 636 G), Department of Health and Human Services, 200 Independence Avenue, SW Washington, DC 20201; ann.norwood@hhs.gov
U2 - PMID: 16207110.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pohl, H.R.
AU - van Engelen, J.G.M.
AU - Wilson, J.
AU - Sips, A.J.A.M.
T1 - Risk assessment of chemicals and pharmaceuticals in the pediatric population: A workshop report
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/06//
VL - 42
IS - 1
M3 - Article
SP - 83
EP - 95
SN - 02732300
AB - Abstract: ATSDR and RIVM organized an Expert Panel Workshop on the Differences Between Children and Adults and Their Relevance to Risk Assessment. The workshop was held in June 2003, in Brussels, Belgium. The purpose of the workshop was to identify data gaps in current scientific knowledge related to children’s health and to recognize areas of mutual interest that would serve as the basis for upcoming ATSDR/RIVM cooperative projects. The aim for both agencies is a better understanding of the issues related to children’s health, and the improvement of scientifically based (chemical) risk assessment in children. Topics discussed included clinical trials/toxicity studies, testing in juvenile animals, PBPK modeling in children, and children’s risk assessment. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Children & animals
KW - Pediatrics
KW - Clinical medicine
KW - Therapeutics
KW - Children
KW - PBPK modeling
KW - Risk assessment
N1 - Accession Number: 17844588; Pohl, H.R. 1; Email Address: hpohl@cdc.gov; van Engelen, J.G.M. 2; Wilson, J. 1; Sips, A.J.A.M. 2; Affiliations: 1: Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, GA 30333, USA; 2: National Institute for Public Health and the Environment, Centre for Substances and Integrated Risk Assessment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Issue Info: Jun2005, Vol. 42 Issue 1, p83; Subject Term: Children & animals; Subject Term: Pediatrics; Subject Term: Clinical medicine; Subject Term: Therapeutics; Author-Supplied Keyword: Children; Author-Supplied Keyword: PBPK modeling; Author-Supplied Keyword: Risk assessment; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.01.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Wu, Yuh-Shen
AU - Chen, Jyh-Cherng
AU - Pi-Cheng Fu, Peter
AU - Chang, Cheng-Nan
AU - Chen, Ming-Hsiang
T1 - Metallic elements study on fine and coarse particulates during daytime and nighttime periods at a traffic sampling site
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2005/06//
VL - 345
IS - 1-3
M3 - Article
SP - 61
EP - 68
SN - 00489697
AB - Abstract: Fine (PM2.5) and coarse (PM2.5–10) particulates were collected simultaneously by using a versatile air pollutant system at a traffic sampling site during daytime and nighttime sampling periods during August 2003 to March 2004. A flame atomic absorption spectrophotometer coupled with hollow cathode lamps were used for chemical analysis. Enrichment factor and principal component analysis were used to compare chemical components and to find the possible emission sources at this traffic sampling site. The variation of metallic element concentrations on fine and coarse particulates during daytime and nighttime was also discussed in this study. Soil dust, traffic exhaust, marine salt and anthropogenic activities were the major pollutant sources at the traffic sampling site in central Taiwan. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOACTIVE aerosols
KW - SAMPLING (Process)
KW - AIR pollution
KW - LIGHT sources
KW - Coarse particulate
KW - Daytime
KW - Fine particulate
KW - Nighttime
KW - Traffic
KW - Versatile air pollutant system
N1 - Accession Number: 18479382; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hk.edu.tw Wu, Yuh-Shen 1 Chen, Jyh-Cherng 1 Pi-Cheng Fu, Peter 2 Chang, Cheng-Nan 3 Chen, Ming-Hsiang 3; Affiliation: 1: Department of Environmental Engineering, Hungkuang University, Sha-Lu, Taichung 433, Taiwan 2: Division of Biochemical Toxicology National Center for Toxicological Research Jefferson, Arkansas 72079, USA 3: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan; Source Info: Jun2005, Vol. 345 Issue 1-3, p61; Subject Term: RADIOACTIVE aerosols; Subject Term: SAMPLING (Process); Subject Term: AIR pollution; Subject Term: LIGHT sources; Author-Supplied Keyword: Coarse particulate; Author-Supplied Keyword: Daytime; Author-Supplied Keyword: Fine particulate; Author-Supplied Keyword: Nighttime; Author-Supplied Keyword: Traffic; Author-Supplied Keyword: Versatile air pollutant system; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.scitotenv.2004.10.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anello, Charles
AU - O'Neill, Robert T
AU - Dubey, Satya
T1 - Multicentre trials: a US regulatory perspective.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2005/06//
VL - 14
IS - 3
M3 - journal article
SP - 303
EP - 318
PB - Sage Publications, Ltd.
SN - 09622802
AB - Multicentre trials are very common in the field of drug development. In recent years, multicentre trials have taken on a multinational and multiregional aspect. We provide a conceptual framework for the use of multicentre trials in the context of drug development, from the perspective of drug regulation in the United States. In this paper, we review some regulatory history, milestones and standards as they relate to multicentre trials. Special attention is given to the similarities and differences in the approaches to multicentre trials in the following documents; Guideline for the Format and Content of the Clinical and Statistical Sections of New Drug Applications, International Conference on Harmonization, Draft Guideline on Statistical Principles for clinical trials and the Guidance for Industry Providing Clinical Evidence of Effectiveness for Human Drug and Biologic Products. The paper includes a consideration of some of the issues in the analysis of data from multicentre trials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - MEDICAL research
KW - TRADE regulation
KW - DRUG development
KW - PHARMACY
KW - DRUG metabolism
KW - UNITED States
N1 - Accession Number: 17109312; Anello, Charles 1,2; Email Address: charles.anello@fda.hhs.gov O'Neill, Robert T 3 Dubey, Satya 4; Affiliation: 1: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, USA 2: Address for correspondence: C. Anello, Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, USA 3: Office of Pharmacoepidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, USA 4: Office of Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, USA; Source Info: Jun2005, Vol. 14 Issue 3, p303; Subject Term: CLINICAL trials; Subject Term: MEDICAL research; Subject Term: TRADE regulation; Subject Term: DRUG development; Subject Term: PHARMACY; Subject Term: DRUG metabolism; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 16p; Document Type: journal article
L3 - 10.1191/0962280205sm398oa
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yucesoy, B.
AU - Johnson, V. J.
AU - Kashon, M. I.
AU - Fluharty, K.
AU - Vallyathan, V.
AU - Luster, M. I.
T1 - Lack of association between antioxidant gene polymorphisms and progressive massive fibrosis in coal miners.
JO - Thorax
JF - Thorax
Y1 - 2005/06//
VL - 60
IS - 6
M3 - Article
SP - 492
EP - 495
SN - 00406376
AB - Background: Oxidative stress plays a major role in the pathogenesis of interstitial lung diseases. The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. Methods: A matched case-control study was conducted to determine the influence of the GSTP1, GSTT1 and MnSOD polymorphisms on susceptibility to progressive massive fibrosis (PMF). Seven hundred ex-coal miners were included in the study; 350 were classified as PMF cases while 350 with a similar underground mining tenure but no clinical or histological evidence of lung disease served as controls. Genotype analysis was performed on genomic DNA, using a 5' nuclease PCR assay. Results: None of the individual investigated polymorphisms and two-way gene-gene interactions had a statistically significant association with PMF. Conclusion: The results of this study suggest that polymorphic genotypes within the GST gene cluster and MnSOD do not affect individual susceptibility to PMF. [ABSTRACT FROM AUTHOR]
AB - Copyright of Thorax is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - OXIDATIVE stress
KW - ENZYMES
KW - GENES
KW - LUNG diseases
KW - GLUTATHIONE
N1 - Accession Number: 17359838; Yucesoy, B. 1; Email Address: yab7@cdc.gov Johnson, V. J. 1 Kashon, M. I. 2 Fluharty, K. 1 Vallyathan, V. 3 Luster, M. I. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safely and Health, Morgantown, West Virginia, USA 2: Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safely and Health, Morgantown, West Virginia, USA; Source Info: Jun2005, Vol. 60 Issue 6, p492; Subject Term: GENETIC polymorphisms; Subject Term: OXIDATIVE stress; Subject Term: ENZYMES; Subject Term: GENES; Subject Term: LUNG diseases; Subject Term: GLUTATHIONE; Number of Pages: 4p; Document Type: Article
L3 - 10.1136/thx.2004.029090
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Ryu, Mi Hyun
AU - Byun, Jung A
T1 - Immunotoxic effect of β-chlorolactic acid on murine splenocyte and peritoneal macrophage function in vitro
JO - Toxicology
JF - Toxicology
Y1 - 2005/06//
VL - 210
IS - 2/3
M3 - Article
SP - 175
EP - 187
SN - 0300483X
AB - Abstract: β-Chlorolactic acid is a major intermediate of 3-monochloro-1,2-propanediol (MCPD) in mammalian species, which a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. β-Chlorolactic acid has not been studied on immunotoxicity. To evaluate the immunomodulatory effect of β-chlorolactic acid on murine splenocyte and macrophage in vitro, we investigated splenocyte blastogenesis by concanavalin A (Con A), anti-CD3 and lipopolysaccharide (LPS), the production of cytokines from splenocyte, and the activity of mouse peritoneal macrophages. β-Chlorolactic acid suppressed significantly splenic blastogenesis to Con A or anti-CD3 from 8.5 to 54.7% at doses comprised between 200 and 800μM. β-Chlorolactic acid also suppressed significantly splenic blastogeneis to LPS from 8.5 to 71.5% at doses comprised between 200 and 800μM. The production level of interferon (IFN)-g on splenocyte culture with Con A was significantly reduced from 21.5 to 51.4% at the higher concentration than 100μM of β-chlorolactic acid. The levels of interleukin (IL)-2 and IL-4 were also decreased 22.6–58.4 and 10.2–36.6%, respectively, at high concentrations of β-chlorolactic acid. There was a significant decrease from 6.1 to 40.8% in the production of nitric oxide (NO) by peritoneal macrophages treated with 400–1000μM β-chlorolactic acid. These results indicate that β-chlorolactic acid might be able to induce immunotoxic effect on immune response of lymphocytes and peritoneal macrophages in vitro. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - RAPID prototyping
KW - IMMUNE response -- Regulation
KW - CELLULAR immunity
KW - SOY sauce manufacturing
KW - β-Chlorolactic acid
KW - Immunotoxicity
KW - Lymphocytes
KW - Macrophages
N1 - Accession Number: 17675197; Lee, Jong Kwon; Email Address: jkleest@yahoo.com Ryu, Mi Hyun 1 Byun, Jung A 1; Affiliation: 1: Division of Immunotoxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, 122-704 Seoul, South Korea; Source Info: Jun2005, Vol. 210 Issue 2/3, p175; Subject Term: KILLER cells; Subject Term: RAPID prototyping; Subject Term: IMMUNE response -- Regulation; Subject Term: CELLULAR immunity; Subject Term: SOY sauce manufacturing; Author-Supplied Keyword: β-Chlorolactic acid; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Lymphocytes; Author-Supplied Keyword: Macrophages; NAICS/Industry Codes: 311941 Mayonnaise, Dressing, and Other Prepared Sauce Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.tox.2005.01.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chuan-ging Wu
AU - Mason, Bobby
AU - Jong, Julia
AU - Erdman, Dean
AU - McKernan, Laurel
AU - Oakley, Meredith
AU - Soucie, Mike
AU - Evatt, Bruce
AU - Yu, Mei-ying W.
T1 - Parvovirus B19 transmission by a high-purity factor VIII concentrate.
JO - Transfusion
JF - Transfusion
Y1 - 2005/06//
VL - 45
IS - 6
M3 - Article
SP - 1003
EP - 1010
PB - Wiley-Blackwell
SN - 00411132
AB - Parvovirus B19 (B19) is known to cause a variety of human diseases in susceptible individuals by close contact via the respiratory route or by transfusion of contaminated blood or blood products. In this study, whether a case of B19 transmission was causally related to the infusion of implicated lots of a solvent/detergent (S/D)-treated, immunoaffinity-purified factor VIII concentrate (antihemophilic factor[human][AHF]) was investigated.Anti-B19 (both immunoglobulin M[IgM] and immunoglobulin G[IgG]) and B19 DNA (by a nucleic acid testing[NAT] procedure) were assayed in two implicated product lots, a plasma pool, and a recipient's serum sample. Analysis of the partial B19 sequences obtained from sequencing clones or direct sequencing of the samples was performed.Only one of the two implicated lots was B19 DNA–positive. It contained 1.3 × 103 genome equivalents (geq or international units[IU]) per mL. The negative lot was derived from plasma screened for B19 DNA by NAT in a minipool format to exclude high-titer donations, whereas the positive lot was mostly from unscreened plasma. This high-purity AHF product had no detectable anti-B19 IgG. A 4-week postinfusion serum sample from a recipient, who received both lots and became ill, was positive for the presence of B19 antibodies (both IgM and IgG) as well as B19 DNA. The B19 sequences from the positive lot, its plasma pool, and the recipient's serum sample were closely related.These findings and the recipient's clinical history support a causal relationship between the implicated AHF product and B19 infection in this recipient. The seronegative patient became infected after receiving 2 × 104 IU (or geq) of B19 DNA, which was present in this S/D-treated, high-purity AHF product. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases -- Transmission
KW - BLOOD transfusion
KW - BLOOD products
KW - IMMUNOGLOBULIN M
KW - NUCLEIC acids
KW - DNA
N1 - Accession Number: 17078016; Chuan-ging Wu 1 Mason, Bobby 1 Jong, Julia 1 Erdman, Dean 1 McKernan, Laurel 1 Oakley, Meredith 1 Soucie, Mike 1 Evatt, Bruce 1 Yu, Mei-ying W. 1; Email Address: yu@cber.fda.gov; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Dartmouth Hitchcock Hemophilia Program, Lebanon, New Hampshire; Source Info: Jun2005, Vol. 45 Issue 6, p1003; Subject Term: VIRUS diseases -- Transmission; Subject Term: BLOOD transfusion; Subject Term: BLOOD products; Subject Term: IMMUNOGLOBULIN M; Subject Term: NUCLEIC acids; Subject Term: DNA; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1537-2995.2005.04387.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ned, Renée M.
AU - Moore, Julie M.
AU - Chaisavaneeyakorn, Sujittra
AU - Udhayakumar, Venkatachalam
T1 - Modulation of immune responses during HIV–malaria co-infection in pregnancy
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2005/06//
VL - 21
IS - 6
M3 - Article
SP - 284
EP - 291
SN - 14714922
AB - Infection with either HIV or malaria during pregnancy often results in adverse outcomes for mother and child. Co-infection further increases the risks of these events, which include maternal anemia and babies with low birth weight. The immunological bases for the increased susceptibility of HIV-infected mothers to malaria and for the effect of co-infection on mother-to-child transmission of HIV are areas of major importance in public health. In this article, we review current data about humoral and cellular responses to HIV–placental-malaria co-infection and present an immunological hypothesis to explain the epidemiological findings. [Copyright &y& Elsevier]
AB - Copyright of Trends in Parasitology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - MALARIA
KW - PREGNANCY complications
KW - PREGNANT women
KW - ANEMIA
KW - LOW birth weight
N1 - Accession Number: 18480736; Ned, Renée M. 1 Moore, Julie M. 2 Chaisavaneeyakorn, Sujittra 3,4 Udhayakumar, Venkatachalam 1; Email Address: vxu0@cdc.gov; Affiliation: 1: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Chamblee, GA 30341, USA 2: Center for Tropical and Emerging Global Diseases and Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA 3: Atlanta Research and Education Foundation, Decatur, GA 30033, USA 4: Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand; Source Info: Jun2005, Vol. 21 Issue 6, p284; Subject Term: HIV infections; Subject Term: MALARIA; Subject Term: PREGNANCY complications; Subject Term: PREGNANT women; Subject Term: ANEMIA; Subject Term: LOW birth weight; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.pt.2005.04.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carter, Colin A.
AU - Estrin, Andrew J.
T1 - Opening of China's Trade, Labour Market Reform and Impact on Rural Wages.
JO - World Economy
JF - World Economy
Y1 - 2005/06//
VL - 28
IS - 6
M3 - Article
SP - 823
EP - 839
PB - Wiley-Blackwell
SN - 03785920
AB - Government policy in China supports urban wages at the expense of returns to farm labour. A model is developed to estimate how WTO accession and complementary labour market reform will influence factor returns in China. With WTO membership, a larger cut in manufacturing tariffs compared to agriculture will improve agriculture's terms of trade and will raise the agricultural wage. Complementary labour market reforms will further boost farm wages as labour exits agriculture in large numbers. We estimate that WTO membership and complementary labour market reforms will result in a decline in the agricultural labour force by about 25 per cent. [ABSTRACT FROM AUTHOR]
AB - Copyright of World Economy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURAL laborers
KW - LABOR market
KW - GOVERNMENT policy
KW - INCOMES policy (Economics)
KW - INTERNATIONAL economic relations
KW - CHINA
KW - WORLD Trade Organization
N1 - Accession Number: 17297956; Carter, Colin A. 1; Estrin, Andrew J. 2; Affiliations: 1: University of California; 2: US Food and Drug Administration; Issue Info: Jun2005, Vol. 28 Issue 6, p823; Thesaurus Term: AGRICULTURAL laborers; Thesaurus Term: LABOR market; Thesaurus Term: GOVERNMENT policy; Thesaurus Term: INCOMES policy (Economics); Thesaurus Term: INTERNATIONAL economic relations; Subject: CHINA ; Company/Entity: WORLD Trade Organization; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 911420 International assistance; Number of Pages: 17p; Document Type: Article
L3 - 10.1111/j.1467-9701.2005.00708.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 2006-08876-002
AN - 2006-08876-002
AU - Reid, Malcolm S.
AU - Angrist, Burt
AU - Baker, Sherryl A.
AU - O'Leary, Siobhan
AU - Stone, Jennifer
AU - Schwartz, Marion
AU - Leiderman, Deborah
AU - Montgomery, Ann
AU - Elkashef, Ahmed
AU - Majewska, Dorota
AU - Robinson, James
AU - Rotrosen, John
T1 - A Placebo Controlled, Double-Blind Study of Mecamylamine Treatment for Cocaine Dependence in Patients Enrolled in an Opiate Replacement Program.
JF - Substance Abuse
JO - Substance Abuse
JA - Subst Abus
Y1 - 2005/06//
VL - 26
IS - 2
SP - 5
EP - 14
CY - US
PB - Haworth Press
SN - 0889-7077
SN - 1547-0164
AD - Reid, Malcolm S., VA NYHHS, 116A, 423 East 23rd Street, New York, NY, US, 10010
N1 - Accession Number: 2006-08876-002. PMID: 16687365 Partial author list: First Author & Affiliation: Reid, Malcolm S.; New York University School of Medicine, Department of Psychiatry, New York, NY, US. Other Publishers: Plenum Publishing Corp.; Springer; Taylor & Francis. Release Date: 20060821. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cocaine; Drug Dependency; Drug Therapy; Mecamylamine; Opiates. Minor Descriptor: Placebo. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Brief Substance Craving Scale; Risk Assessment Battery; Addiction Severity Index DOI: 10.1037/t00025-000; Hamilton Anxiety Rating Scale DOI: 10.1037/t02824-000; Hamilton Rating Scale for Depression DOI: 10.1037/t04100-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jun, 2005.
AB - A placebo controlled, double-blind trial of mecamylamine treatment of cocaine dependence was performed in methadone or LAAM maintained subjects who met DSM-IV criteria for cocaine dependence. After an eight-week placebo run-in screening period, 35 subjects were randomly assigned to receive either mecamylamine (6 mg/day) or placebo transdermal patches for a 16-week treatment period. Outcome measures included quantitative urine benzoylecognine (BE) levels, self-report of cocaine use, cocaine craving, global impression scores, mood, retention, and safety. Mecamylamine was well tolerated, and study retention did not differ by treatment group. Evidence for cocaine use, based on urine BE levels and cocaine abstinence rates, did not differ by treatment group. Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group. This pilot study does not support the effectiveness of mecamylamine for the treatment of cocaine dependence in methadone or LAAM maintained patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - placebo controlled
KW - mecamylamine treatment
KW - cocaine dependence
KW - opiate replacement program
KW - 2005
KW - Cocaine
KW - Drug Dependency
KW - Drug Therapy
KW - Mecamylamine
KW - Opiates
KW - Placebo
KW - 2005
U1 - Sponsor: National Institute on Drug Abuse. Grant: YO1 DA 50038. Recipients: No recipient indicated
DO - 10.1300/J465v26n02_02
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08876-002&site=ehost-live&scope=site
UR - malcolm.reid@med.va.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08252-005
AN - 2005-08252-005
AU - McKay, Colleen
AU - Johnsen, Mathew
AU - Stein, Reva
T1 - Employment outcomes in Massachusetts Clubhouses.
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2005///Sum 2005
VL - 29
IS - 1
SP - 25
EP - 33
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - McKay, Colleen
N1 - Accession Number: 2005-08252-005. PMID: 16075694 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: McKay, Colleen; Program for Clubhouse Research, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20050815. Correction Date: 20150824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Supported Employment. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sum 2005.
AB - Employment outcomes of individuals participating in 17 Massachusetts Clubhouses certified by the International Center for Clubhouse Development were examined through an annual survey. Major components of employment programs in contemporary clubhouses are identified and individual employment outcomes are described. Within contemporary practice in ICCD clubhouses in this sample, clubhouses provided a three-pronged approach to employment. Between 1998-2001,1702 individuals worked in 2714 separate job placements, employed in Transitional (TE), Supported (SE), and Independent Employment (IE). Forty percent of members with more than one job (N = 385) participated in at least one TE. Individuals with longer memberships tended to work longer and had higher job earnings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment outcomes
KW - Massachusetts Clubhouses
KW - job placements
KW - employment programs
KW - mental illness
KW - transitional employment
KW - supported employment
KW - independent employment
KW - 2005
KW - Employment Status
KW - Supported Employment
KW - 2005
DO - 10.2975/29.2005.25.33
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08252-005&site=ehost-live&scope=site
UR - colleen.mckay@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06207-003
AN - 2005-06207-003
AU - Rivera, Edil Torres
AU - Wilbur, Michael
AU - Frank-Saraceni, James
AU - Roberts-Wilbur, Janice
AU - Phan, Loan T.
AU - Garrett, Michael T.
T1 - Group Chaos Theory: A Metaphor and Model for Group Work.
JF - Journal for Specialists in Group Work
JO - Journal for Specialists in Group Work
Y1 - 2005/06//
VL - 30
IS - 2
SP - 111
EP - 134
CY - United Kingdom
PB - Taylor & Francis
SN - 0193-3922
SN - 1549-6295
AD - Rivera, Edil Torres, Counseling, School, and Educational Psychology Department, University at Buffalo, 409 Baldy Hall, Buffalo, NY, US, 14260
N1 - Accession Number: 2005-06207-003. Partial author list: First Author & Affiliation: Rivera, Edil Torres; Counseling, School and Educational Psychology Department, University at Buffalo, Buffalo, NY, US. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chaos Theory; Group Counseling; Group Dynamics; Group Psychotherapy; Mathematical Modeling. Classification: Group & Family Therapy (3313). Population: Human (10). References Available: Y. Page Count: 24. Issue Publication Date: Jun, 2005.
AB - Group phenomena and interactions are described through the use of the chaos theory constructs and characteristics of sensitive dependence on initial conditions, phase space, turbulence, emergence, self-organization, dissipation, iteration, bifurcation, and attractors and fractals. These constructs and theoretical tenets are presented as applicable metaphors to benefit, expand, and enhance group work practice and knowledge. Guidelines are suggested for application, as well as mathematical research models and procedures that may better address the nonlinear dimensions of groups. Suggestions for future group practice and research are also provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - group chaos theory
KW - group work
KW - mathematical research models
KW - metaphor
KW - 2005
KW - Chaos Theory
KW - Group Counseling
KW - Group Dynamics
KW - Group Psychotherapy
KW - Mathematical Modeling
KW - 2005
DO - 10.1080/01933920590925968
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06207-003&site=ehost-live&scope=site
UR - etrivera@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08287-002
AN - 2005-08287-002
AU - Norwood, Ann E.
T1 - Commentary on 'Understanding Mass Panic and Other Collective Responses to Threat and Disaster': Debunking the Myth of Panic.
JF - Psychiatry: Interpersonal and Biological Processes
JO - Psychiatry: Interpersonal and Biological Processes
JA - Psychiatry
Y1 - 2005///Sum 2005
VL - 68
IS - 2
SP - 114
EP - 114
CY - US
PB - Guilford Publications
SN - 0033-2747
SN - 1943-281X
AD - Norwood, Ann E., Office of Public Health Emergency Preparedness, Department of Health and Human Services, (Room 636 G), 200 Independence Avenue, SW, Washington, DC, US, 20201
N1 - Accession Number: 2005-08287-002. Other Journal Title: Psychiatry: Journal for the Study of Interpersonal Processes. Partial author list: First Author & Affiliation: Norwood, Ann E.; Office of Public Health Emergency Preparedness, Department of Health and Human Services, Washington, DC, US. Other Publishers: Taylor & Francis. Release Date: 20050815. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Attachment Behavior; Collective Behavior; Disasters; Panic; Self-Preservation. Minor Descriptor: Models; Taxonomies; Threat. Classification: Neuroses & Anxiety Disorders (3215). Population: Human (10). Page Count: 1. Issue Publication Date: Sum 2005.
AB - Comments on the article by Anthony R. Mawson (see record [rid]2005-08287-001[/rid]).This excellent review of group responses to threat should be a 'must read' for all those involved in preparing for and responding to emergencies, especially political leaders. Despite considerable effort by many individuals found in this article's reference list, the myth of mass panic stubbornly refuses to die. Key decisionmakers holding this belief all too often subscribe to a corollary that the best way to prevent panic is to withhold 'bad news' from the public and to over-reassure. Thus, the wheels are set in motion to create the very panic officials aim to prevent. Mawson's article masterfully summarizes the data to dispel this pernicious myth and offers a compelling competing hypothesis to explain behavior--the primacy of social attachment behaviors in an emergency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - physical danger
KW - mass panic
KW - terrorist attacks
KW - threat
KW - disaster
KW - social attachment model
KW - self preservation
KW - collective behavior
KW - typology
KW - 2005
KW - Attachment Behavior
KW - Collective Behavior
KW - Disasters
KW - Panic
KW - Self-Preservation
KW - Models
KW - Taxonomies
KW - Threat
KW - 2005
DO - 10.1521/psyc.2005.68.2.114
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08287-002&site=ehost-live&scope=site
UR - ann.norwood@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-11472-001
AN - 2005-11472-001
AU - Alexander, Greg R.
AU - Kogan, Michael D.
T1 - The Expanding Role of MCH Epidemiologists: Evolving Job Description, Tasks and Skill Areas, and Sources of Training Support.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2005/06//
VL - 9
IS - 2
SP - 121
EP - 123
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Alexander, Greg R., Department of Maternal and Child Health, University of Alabama at Birmingham, School of Public Health, 1530 3rd Avenue South RPHB 330Q, Birmingham, AL, US, 35294-0022
N1 - Accession Number: 2005-11472-001. PMID: 15965617 Partial author list: First Author & Affiliation: Alexander, Greg R.; Department of Maternal and Child Health, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, US. Release Date: 20060327. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Epidemiology; Experimentation; Health; Job Analysis; Medical Education. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jun, 2005.
AB - The last two decades have brought increased attention to the need for the training of Maternal and Child Health (MCH) epidemiologists to enhance the analytical and research capacity of the MCH field. The various tasks and functions of MCH epidemiologists have been widely debated without clear resolution. Questions have been raised as to whether MCH epidemiologists are in fact more akin to health service researchers or biostatisticians than traditional epidemiologists. Ongoing support for both continuing and graduate education in MCH epidemiology clearly remains indicated. However, while seeking a general consensus in our field on basic academic competencies for MCH epidemiologists is a worthy pursuit, it may likely remain an elusive goal, as this position continues to evolve as a MCH profession. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternal and child health epidemiologists
KW - job description
KW - skill areas
KW - health service
KW - training support
KW - research
KW - 2005
KW - Epidemiology
KW - Experimentation
KW - Health
KW - Job Analysis
KW - Medical Education
KW - 2005
DO - 10.1007/s10995-005-4903-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11472-001&site=ehost-live&scope=site
UR - mkogan@hrsa.gov
UR - alexandg@uab.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13505-010
AN - 2005-13505-010
AU - Corey, Kristen
AU - Cohen, Marcia
AU - Healy, Heather
AU - Galvin, Deborah
AU - Bekelman, Alan
AU - Edberg, Mark
T1 - Impact of the September 11 attack on flight attendants: A study of an essential first responder group.
JF - International Journal of Emergency Mental Health
JO - International Journal of Emergency Mental Health
JA - Int J Emerg Ment Health
Y1 - 2005///Sum 2005
VL - 7
IS - 3
SP - 227
EP - 240
CY - US
PB - Chevron Publishing
SN - 1522-4821
AD - Corey, Kristen
N1 - Accession Number: 2005-13505-010. PMID: 16265979 Other Journal Title: International Journal of Emergency Mental Health and Human Resilience. Partial author list: First Author & Affiliation: Corey, Kristen; Development Services Group, Inc., US. Other Publishers: OMICS Group. Release Date: 20060117. Correction Date: 20140728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aerospace Personnel; Occupational Safety; Occupational Stress; Working Conditions. Minor Descriptor: Mental Health; Posttraumatic Stress Disorder. Classification: Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Sum 2005.
AB - This paper discusses a study (funded by the Center for Substance Abuse Prevention) of the health/mental health and work-related well-being of flight attendants in the aftermath of September 11. Flight attendants, as an occupational group, had a distinctive exposure to September 11. In addition to work-related exposure in the immediate aftermath of the attacks, flight attendants have experienced major and ongoing changes in their work environment and job description and many have been exposed to potentially traumatic incidents on the job. Analysis of survey and focus group data from flight attendants in the Association of Flight Attendants showed high reported stress and related mental health and behavioral impacts among flight attendants since September 11. A significant new finding is that the effect of continued trauma in the flight attendants' work environment impacted their ability to recover from the original trauma associated with the events of that day. This study highlights the role of the after-effects of a traumatic event on trauma response and suggests that direct exposure, as traditionally defined, is not necessarily a primary mediating factor in trauma response for this occupational group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - flight attendants
KW - 9/11 attack impact
KW - occupational stress
KW - work-related mental health
KW - 2005
KW - Aerospace Personnel
KW - Occupational Safety
KW - Occupational Stress
KW - Working Conditions
KW - Mental Health
KW - Posttraumatic Stress Disorder
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13505-010&site=ehost-live&scope=site
UR - HHealy@afanet.org
UR - kcorey@dsgonline.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07066-011
AN - 2005-07066-011
AU - Nguyen, Ly
AU - Arganza, Girlyn F.
AU - Huang, Larke N.
AU - Liao, Qinghong
AU - Nguyen, Hoang T.
AU - Santiago, Rolando
T1 - Psychiatric diagnoses and clinical characteristics of Asian American youth in children's services: Erratum.
JF - Journal of Child and Family Studies
JO - Journal of Child and Family Studies
JA - J Child Fam Stud
Y1 - 2005/06//
VL - 14
IS - 2
SP - 317
EP - 317
CY - Germany
PB - Springer
SN - 1062-1024
SN - 1573-2843
AD - Nguyen, Ly, 803 Bonifant Street, Silver Spring, MD, US, 20910
N1 - Accession Number: 2005-07066-011. Partial author list: First Author & Affiliation: Nguyen, Ly; Center for Urban Health Research, Morgan State University, Baltimore, MD, US. Release Date: 20050801. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Asians; Child Welfare; Mental Health Services; Psychiatric Symptoms; Psychodiagnosis. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 1. Issue Publication Date: Jun, 2005.
AB - Reports an error in the original article by Nguyen et. al. (Journal of Child & Family Studies, 2004[Dec], Vol 13[(4)], 483-495). The affiliations for the article are incorrect on the website. The correct version is presented. (The following abstract of this article originally appeared in record [rid]2004-20136-008[/rid].)This study examined the psychiatric diagnoses and clinical characteristics of the 981 Asian American children enrolled in the first phase of the Comprehensive Community Mental Health Services for Children and Their Families Program. Asian Americans were less likely than non-Asian Americans to receive diagnoses of depression and ADHD and more likely to receive diagnoses of anxiety and adjustment disorder. As compared to non-Asians, Asian Americans were significantly more likely to be rated with severe functional impairment in community role performance, self-harmful behavior, and thinking. There was also a trend for fewer externalizing behavior problems. Implications for research and practice are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric diagnoses
KW - clinical characteristics
KW - Asian American youth
KW - children's services
KW - 2005
KW - Asians
KW - Child Welfare
KW - Mental Health Services
KW - Psychiatric Symptoms
KW - Psychodiagnosis
KW - 2005
DO - 10.1007/s10826-005-5669-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07066-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-14468-015
AN - 2011-14468-015
AU - Simeonov, Peter I.
AU - Hsiao, Hongwei
AU - Dotson, Brian W.
AU - Ammons, Douglas E.
T1 - Height effects in real and virtual environments.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 2005///Sum 2005
VL - 47
IS - 2
SP - 430
EP - 438
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
AD - Simeonov, Peter I., 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2011-14468-015. PMID: 16170948 Partial author list: First Author & Affiliation: Simeonov, Peter I.; National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Sage Publications. Release Date: 20110815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Risk Factors; Virtual Reality. Minor Descriptor: Anxiety; Physiology; Working Conditions. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sum 2005. Publication History: Accepted Date: Jun 18, 2004; First Submitted Date: Jun 9, 2003.
AB - The study compared human perceptions of height, danger, and anxiety, as well as skin conductance and heart rate responses and postural instability effects, in real and virtual height environments. The 24 participants (12 men, 12 women), whose average age was 23.6 years, performed 'lean-over-the-railing' and standing tasks on real and comparable virtual balconies, using a surround-screen virtual reality (SSVR) system. The results indicate that the virtual display of elevation provided realistic perceptual experience and induced some physiological responses and postural instability effects comparable to those found in a real environment. It appears that a simulation of elevated work environment in a SSVR system, although with reduced visual fidelity, is a valid tool for safety research. Potential applications of this study include the design of virtual environments that will help in safe evaluation of human performance at elevation, identification of risk factors leading to fall incidents, and assessment of new fall prevention strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - virtual reality
KW - risk factors
KW - anxiety
KW - physiological responses
KW - work environments
KW - 2005
KW - Risk Factors
KW - Virtual Reality
KW - Anxiety
KW - Physiology
KW - Working Conditions
KW - 2005
DO - 10.1518/0018720054679506
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-14468-015&site=ehost-live&scope=site
UR - psimeonov@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06599-001
AN - 2005-06599-001
AU - Reyes, Valvincent A.
AU - Hicklin, Thomas A.
T1 - Anger in the Combat Zone.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2005/06//
VL - 170
IS - 6
SP - 483
EP - 487
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Reyes, Valvincent A., Community Mental Health Center, Division of Mental Health, USA MEDDAC, Fort Irwin, CA, US, 92310-5109
N1 - Accession Number: 2005-06599-001. PMID: 16001596 Partial author list: First Author & Affiliation: Reyes, Valvincent A.; Community Mental Health Center, Division of Mental Health, USA MEDDAC, Fort Irwin, CA, US. Release Date: 20051017. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual Tri-Service Combat Stress Conference, 11th, 2003, Camp Pendleton, CA, US. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Anger Control; Combat Experience; Health Care Services; Military Personnel; Stress Management. Classification: Health & Mental Health Services (3370); Military Psychology (3800). Population: Human (10). Location: Afghanistan. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 5. Issue Publication Date: Jun, 2005.
AB - A U.S. Army Reserve Combat Stress Control prevention team was dispatched to Afghanistan in support of Operation Enduring Freedom to provide preventative mental health care to a U.S. Army airborne division and Special Operations forces. The team's mission was to ensure mental health readiness of units in the area of operations. In Bagram, Afghanistan, the Combat Stress Control team identified anger as a very prevalent emotion in the combat zone. Anger management interventions with individual and group counseling were implemented to help soldiers cope with anger. Of 7,000 military personnel stationed there during the team's rotation, there was not one completed suicide or homicide. This article describes how the 113th Medical Company identified, treated, and controlled anger at Bagram Airbase, Afghanistan, between June 20, 2002, and December 20, 2002, with anger management interventions. This article does not address the psychophysiological features of anger. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - combat zone
KW - anger
KW - mental health care
KW - US military personnel
KW - combat stress control prevention team
KW - anger management interventions
KW - 2005
KW - Anger Control
KW - Combat Experience
KW - Health Care Services
KW - Military Personnel
KW - Stress Management
KW - 2005
DO - 10.7205/MILMED.170.6.483
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06599-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-05998-014
AN - 2005-05998-014
AU - Crosby, Richard A.
AU - DiClemente, Ralph J.
AU - Wingood, Gina M.
AU - Salazar, Laura F.
AU - Rose, Eve
AU - Levine, David
AU - Brown, Larry
AU - Lescano, Celia
AU - Pugatch, David
AU - Flanigan, Timothy
AU - Fernandez, Isa
AU - Schlenger, William
AU - Silver, Barbara J.
T1 - Condom failure among adolescents: Implications for STD prevention.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2005/06//
VL - 36
IS - 6
SP - 534
EP - 536
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Crosby, Richard A., College of Public Health, Department of Health Behavior, University of Kentucky, 121 Washington Ave., Room 111C, Lexington, KY, US, 40506-0003
N1 - Accession Number: 2005-05998-014. PMID: 15901520 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Crosby, Richard A.; Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA, US. Release Date: 20050613. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Condoms; Prevention; Sexually Transmitted Diseases. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Jun, 2005.
AB - This study of 921 adolescents found condom failure (past 90 days) was experienced by at least one-third of the sample, regardless of gender. Frequency of condom failure was positively associated with STD diagnosis (AOR = 1.22, 95% CI = 1.01-1.48), with the odds of testing positive increasing 22% for each added event of failure. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - condom failure
KW - STD prevention
KW - STD diagnosis
KW - 2005
KW - Condoms
KW - Prevention
KW - Sexually Transmitted Diseases
KW - 2005
DO - 10.1016/j.jadohealth.2004.05.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-05998-014&site=ehost-live&scope=site
UR - crosby@uky.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08312-002
AN - 2005-08312-002
AU - DeSena, Allen D.
AU - Murphy, Robert A.
AU - Douglas-Palumberi, Heather
AU - Blau, Gary
AU - Kelly, Blandina
AU - Horwitz, Sarah M.
AU - Kaufman, Joan
T1 - SAFE Homes: Is it worth the cost? An evaluation of a group home permanency planning program for children who first enter out-of-home care.
JF - Child Abuse & Neglect
JO - Child Abuse & Neglect
JA - Child Abuse Negl
Y1 - 2005/06//
VL - 29
IS - 6
SP - 627
EP - 643
CY - Netherlands
PB - Elsevier Science
SN - 0145-2134
AD - Kaufman, Joan, Yale University, Department of Psychiatry, Child and Adolescent Research and Education (CARE) Program, University Towers, Suite H, 100 York Street, New Haven, CT, US, 06511
N1 - Accession Number: 2005-08312-002. PMID: 15979706 Partial author list: First Author & Affiliation: DeSena, Allen D.; Yale University, Department of Psychiatry, Child and Adolescent Research and Education (CARE) Program, New Haven, CT, US. Release Date: 20060221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Continuum of Care; Foster Care; Group Homes; Residential Care Institutions. Minor Descriptor: Program Evaluation; Treatment Planning. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jun, 2005.
AB - Objective: To evaluate the SAFE Homes (SH) program, a short-term group care program for children between 3 and 12 years of age who enter care for the first time. The program aims to improve case outcomes by consolidating resources to facilitate assessment and treatment planning. Methods: The 1-year outcomes of 342 children who received SAFE Home services and 342 matched foster care (FC) control children were compared. The 684 subjects used in this report were selected from a larger pool of 909 subjects using propensity score matching to control for hidden bias in treatment group assignment. We hypothesized that SAFE Homes would result in greater continuity of care for children (e.g., fewer placements, more placements with siblings and in towns of origin), identification of more relatives for substitute care when needed, reduced use of high-cost restrictive care settings (e.g., residential, inpatient), and reduced rates of re-abuse through earlier detection and provision of services to meet child and family treatment needs. Results: Prior to the initiation of the SAFE Homes program, 75% of the children who entered care in the State experienced three or more placements in the first year. The outcomes of both the SH and FC cases were significantly improved over pre-SAFE Home State statistics. The FC group, however, had comparable or better outcomes on most variables examined. In addition, the total cost for out-of-home care for the children in FC was significantly less, despite the fact that the two groups spent similar amounts of time in care (average time in care: 7 months). This finding held when the total placement cost was calculated using the State reimbursement rate of $206.00 per day for SAFE Home care (SH: $20,851 ± 24,231; FC: $8,441 ± 21,126,; p < .001), and a conservative SAFE Home program fee of $85.00 per day that only considered the child care and custodial starring costs uniquely associated with the program (SH: $13,314 ± 21,718; FC: $8,441 ± 21,126, p < .001). Conclusion: Improvements in outcomes related to continuity of care can be attained through staff training. The SAFE Home model of care is not cost-effective for first-time placements. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - SAFE homes program
KW - group care program
KW - home permanency planning
KW - treatment planning
KW - continuity of care
KW - child care
KW - 2005
KW - Child Care
KW - Continuum of Care
KW - Foster Care
KW - Group Homes
KW - Residential Care Institutions
KW - Program Evaluation
KW - Treatment Planning
KW - 2005
DO - 10.1016/j.chiabu.2004.05.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08312-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06166-014
AN - 2005-06166-014
AU - Mark, Tami L.
AU - Buck, Jeffrey A.
T1 - Components of Spending for Medicaid Mental Health Services, 2001.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/06//
VL - 56
IS - 6
SP - 648
EP - 648
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Buck, Jeffrey A., Center for Mental Health Services, 1 Choke Cherry Road, 6-1061, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06166-014. PMID: 15939938 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Mark, Tami L.; Medstat, Washington, DC, US. Release Date: 20050815. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Medicaid; Mental Health Services. Minor Descriptor: Treatment Facilities. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 1. Issue Publication Date: Jun, 2005.
AB - Describes briefly the distribution of expenditures for Medicaid mental health services by provider type (both specialty and general health care) in the US in 2001. Psychotropic drugs and multiservice mental health organizations were major components of such spending and accounted for a major proportion of the increase in such spending. These increases suggest that these services merit more attention in discussions of policies for public mental health services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - Medicaid
KW - mental health expenditures
KW - psychotropic drugs
KW - 2005
KW - Health Care Costs
KW - Medicaid
KW - Mental Health Services
KW - Treatment Facilities
KW - 2005
DO - 10.1176/appi.ps.56.6.648
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06166-014&site=ehost-live&scope=site
UR - jbuck@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10899-003
AN - 2006-10899-003
AU - Hellinger, Fred J.
T1 - Commentary--Assessing the Impact of Managed Care Patient Protection Laws: Problems and Pitfalls.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2005/06//
VL - 40
IS - 3
SP - 669
EP - 674
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Hellinger, Fred J., Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-10899-003. PMID: 15960685 Partial author list: First Author & Affiliation: Hellinger, Fred J.; Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Client Rights; Client Satisfaction; Health Care Utilization; Health Maintenance Organizations; Managed Care. Minor Descriptor: Health Care Services; Laws; Safety; Trust (Social Behavior). Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2005.
AB - Comments on the article by Sloan et al. (see record [rid]2006-10899-002[/rid]), whose study found that patient protection laws have had little or no impact on either the utilization of health care services or on patient trust in the health care system. The current author suggests there are two plausible explanations for these findings, and the two explanations are not incompatible. The first explanation is that patient protection laws have (as found by Sloan et al.) indeed had little impact. The second explanation is that the analytic design of this study is unable to detect the impact of patient protection laws on utilization or patient trust because of specification problems in the design as they relate to the magnitude of the impact. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - managed care
KW - patient protection laws
KW - health services utilization
KW - health care
KW - patient satisfaction
KW - HMOs
KW - 2005
KW - Client Rights
KW - Client Satisfaction
KW - Health Care Utilization
KW - Health Maintenance Organizations
KW - Managed Care
KW - Health Care Services
KW - Laws
KW - Safety
KW - Trust (Social Behavior)
KW - 2005
DO - 10.1111/j.1475-6773.2005.00379.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10899-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Schmechel, D.
AU - Simpson, J. P.
AU - Lewis, D. M.
T1 - The production and characterization of monoclonal antibodies to the fungus Aspergillus versicolor.
JO - Indoor Air
JF - Indoor Air
Y1 - 2005/06/02/Jun2005 Supplement 9
VL - 15
M3 - Article
SP - 11
EP - 19
PB - Wiley-Blackwell
SN - 09056947
AB - Fungal exposure measurements in indoor environments require accurate and precise monitoring methods. Such techniques may be based on monoclonal antibodies (Mabs) and enzyme-linked immunosorbent assays (ELISA) and here we report the cross-reactivity patterns of Mabs produced against Aspergillus versicolor. Balb/c mice were immunized with the particulate fraction of homogenized spores and 46 Mabs (35 IgM, nine IgG3, two IgG1) were produced and tested for cross-reactivity against 55 fungal species. None of the Mabs was found to be species-specific for A. versicolor. Several Mabs strongly cross-reacted with most Aspergillus, Penicillium and Eurotium species and some Mabs also cross-reacted with Paecilomyces variotii and several Cladosporium and Stachybotrys species. Our results show that antibody responses in mice against spores of A. versicolor are dominated by highly cross-reactive antibodies of the IgM isotype. The widespread cross-reactivity suggests that the specificity of antibodies to be used for the detection of fungi in environmental samples need to be thoroughly characterized in order to avoid ambiguities in the interpretation of monitoring results. Furthermore, accurate estimates of spore concentrations may require the application of species-specific Mabs in order to avoid bias in result interpretation because of the differential reactivity of cross-reactive Mabs with different fungi. Producers of monoclonal or polyclonal antibodies for the detection of fungi in environmental or clinical samples need to verify antibody reactivity patterns and accurately report that information to potential users. Furthermore, immunoassays based on mouse or human serum or purified immunoglobulin fractions need to consider antibody cross-reactivity as a potential confounding factor during interpretation of results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - ASPERGILLUS
KW - FUNGI
KW - INDOOR air pollution
KW - IMMUNOASSAY
KW - Aspergillus
KW - Enzyme-linked immunosorbent assays
KW - Exposure measurements
KW - Fungi
KW - Monoclonal antibodies
N1 - Accession Number: 17065557; Schmechel, D. 1; Email Address: dschmechel@cdc.gov Simpson, J. P. 1 Lewis, D. M. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA; Source Info: Jun2005 Supplement 9, Vol. 15, p11; Subject Term: MONOCLONAL antibodies; Subject Term: ASPERGILLUS; Subject Term: FUNGI; Subject Term: INDOOR air pollution; Subject Term: IMMUNOASSAY; Author-Supplied Keyword: Aspergillus ; Author-Supplied Keyword: Enzyme-linked immunosorbent assays; Author-Supplied Keyword: Exposure measurements; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Monoclonal antibodies; Number of Pages: 9p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2005.00340.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17065557&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rao, C. Y.
AU - Cox-Ganser, J. M.
AU - Chew, G. L.
AU - Doekes, G.
AU - White, S.
T1 - Use of surrogate markers of biological agents in air and settled dust samples to evaluate a water-damaged hospital.
JO - Indoor Air
JF - Indoor Air
Y1 - 2005/06/02/Jun2005 Supplement 9
VL - 15
M3 - Article
SP - 89
EP - 97
PB - Wiley-Blackwell
SN - 09056947
AB - An environmental survey was conducted in two hospital buildings in Montana, one of which had historical water incursion on the top floors and higher prevalence of reported respiratory symptoms that improved when the occupants were away from work. We measured culturable fungi and bacteria, fungal spores, endotoxin, and sub-micron particles in air; and culturable fungi and bacteria, endotoxin, markers of fungi (extra-cellular polysaccharides specific forPenicillium/Aspergillus, ergosterol, andβ(1→3) glucans) and cat allergen in chair and floor dusts. For the analytes measured in air, the correlation coefficients ranged from 0.43 to 0.78 (P < 0.05). In chair dust,β(1→3) glucan concentrations correlated with culturable fungi and ergosterol concentrations. We found that sub-micron particles and markers of microbiological agents, but not culturable microbiological agents, were significantly positively associated with the building that had both historical water damage and higher prevalence of reported respiratory symptoms. Chair dust measurements tended to be higher in the non-complaint building. These results suggest that air and floor dust measurements of marker compounds may be better indicators of current health risk in a water-damaged environment than chair dust measurements or measurements of culturable fungi or bacteria in air or settled dust. Detection and quantification of nonculture-based microbiological markers and/or agents of disease may be useful methods to assess microbial contamination and to more accurately evaluate microbial exposures in the indoor environment for exposure-response studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - FUNGI
KW - BIOCHEMICAL markers
KW - BIOCHEMISTRY
KW - MICROBIOLOGY
KW - Bacteria
KW - Cat allergen
KW - Endotoxin
KW - Ergosterol
KW - Fungi
KW - Glucans
KW - Hospitals
KW - Particles
N1 - Accession Number: 17065549; Rao, C. Y. 1; Email Address: cnr3@cdc.gov Cox-Ganser, J. M. 1 Chew, G. L. 2 Doekes, G. 3 White, S. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 2: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA 3: Institute for Risk Assessment Sciences (IRAS), University of Utrecht, Utrecht, the Netherlands; Source Info: Jun2005 Supplement 9, Vol. 15, p89; Subject Term: RESPIRATORY diseases; Subject Term: FUNGI; Subject Term: BIOCHEMICAL markers; Subject Term: BIOCHEMISTRY; Subject Term: MICROBIOLOGY; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Cat allergen; Author-Supplied Keyword: Endotoxin; Author-Supplied Keyword: Ergosterol; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Glucans; Author-Supplied Keyword: Hospitals; Author-Supplied Keyword: Particles; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1600-0668.2005.00348.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17065549&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kogan, Michael
AU - Dyck, Peter
T1 - Editorial: The National Survey of Children With Special Health Care Needs: Using State-Level Data to Improve Systems of Care for Children.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2005/06/02/Jun2005 Supplement
VL - 9
M3 - Editorial
SP - 1
EP - 2
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Discusses the 2001 National Survey of Children with Special Health Care Needs (CSHCN) in the United States. Objectives of the survey; Performance measures related to CSHCN from the Maternal and Child Health Bureau's Title V Block Grant performances measurement system; Importance of conducting state-specific analyses.
KW - CHILDREN -- Health
KW - CHILD health services
KW - CHILD care
KW - MEDICAL care
KW - UNITED States
N1 - Accession Number: 17406457; Kogan, Michael 1; Email Address: mkogan@hrsa.gov Dyck, Peter 1; Affiliation: 1: Maternal and Child Health Bureau, Health Services and Resources Administration, 5600 Fishers Lane, Room 18-41 Rockville 20857; Source Info: Jun2005 Supplement, Vol. 9, p1; Subject Term: CHILDREN -- Health; Subject Term: CHILD health services; Subject Term: CHILD care; Subject Term: MEDICAL care; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1007/s10995-005-4917-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17406457&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106529361
T1 - Editorial: The National Survey of Children With Special Health Care Needs: using state-level data to improve systems of care for children.
AU - Kogan MD
AU - van Dyck PC
Y1 - 2005/06/02/Jun2005 Supplement
N1 - Accession Number: 106529361. Language: English. Entry Date: 20051021. Revision Date: 20150820. Publication Type: Journal Article; editorial. Supplement Title: Jun2005 Supplement. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. NLM UID: 9715672.
KW - Child Health
KW - Child, Disabled -- United States
KW - Health Services Needs and Demand -- In Infancy and Childhood
KW - Surveys
KW - Child
KW - Health and Welfare Planning
KW - Health Care Costs
KW - Health Services Accessibility -- In Infancy and Childhood
KW - United States
SP - S1
EP - 2
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 9
CY - ,
PB - Springer Science & Business Media B.V.
SN - 1092-7875
AD - Maternal and Child Health Bureau, Health Services and Resources Administration, 5600 Fishers Lane, Room 18-41 Rockville 20857
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106529361&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Dambach, Megan J.
AU - Trecki, Jordan
AU - Martin, Natalia
AU - Markovitz, Nancy S.
T1 - 159. Unexpected Genetic Alterations Occur in Untargeted Genes during the Construction of Viral Vectors
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2005/06/02/
VL - 11
M3 - Abstract
SP - 64
EP - 64
SN - 15250016
AB - An abstract of the article "Unexpected Genetic Alterations Occur in Untargeted Genes during the Construction of Viral Vectors," by Megan J. Dambach, Jordan Trecki, Natalia Martin and Nancy S. Markovitz is presented.
KW - GENETIC vectors
KW - GENES
KW - ABSTRACTS
N1 - Accession Number: 18293156; Dambach, Megan J. 1 Trecki, Jordan 1 Martin, Natalia 1 Markovitz, Nancy S. 1; Affiliation: 1: Division of Cellular and Gene Therapies, US Food and Drug Administration/ CBER, Bethesda, MD; Source Info: Jun2005, Vol. 11, p64; Subject Term: GENETIC vectors; Subject Term: GENES; Subject Term: ABSTRACTS; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ymthe.2005.06.163
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18293156&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Baolin
AU - Yang, Linda
AU - Zheng, Yi
T1 - Novel intermediate of Rac GTPase activation by guanine nucleotide exchange factor
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/06/03/
VL - 331
IS - 2
M3 - Article
SP - 413
EP - 421
SN - 0006291X
AB - Abstract: The biochemical role of guanine nucleotide exchange factors (GEFs) in catalyzing small GTPase GDP–GTP exchange is thought to be twofold: stimulation of GDP dissociation and stabilization of a nucleotide-free GTPase intermediate. Here we report that TrioN, a Dbl family GEF, activates Rac1 by facilitating GTP binding to, as well as stimulating GDP dissociation from, Rac1. The TrioN-catalyzed GDP dissociation is dependent upon the structural nature and the concentration of free nucleotide, and nucleotide binding serves as the rate-limiting step of the GEF reaction. The TrioN-stimulated nucleotide exchange may undergo a novel two nucleotide-one G-protein intermediate involving two cryptic subsites on Rac1 induced by the GEF, with one subsite contributing to the recognition of the β/γ phosphates of the incoming GTP and another to the binding of the guanine base of the leaving GDP. We propose that the Rac GEF reaction may proceed by competitive displacement of bound GDP by GTP through a transient intermediate of GEF–[GTP–Rac–GDP]. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - G proteins
KW - NUCLEOTIDES
KW - DISSOCIATION (Chemistry)
KW - PHOSPHATES
KW - GDP-dissociation
KW - GTP binding
KW - Guanine nucleotide exchange
KW - Reaction mechanism
KW - Rho GTPases
N1 - Accession Number: 17021106; Zhang, Baolin 1 Yang, Linda 2 Zheng, Yi 2; Email Address: yi.zheng@chmcc.org; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Therapeutic Proteins, Bethesda, MD 20892, USA 2: Division of Experimental Hematology, Children’s Hospital Research Foundation, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Source Info: Jun2005, Vol. 331 Issue 2, p413; Subject Term: G proteins; Subject Term: NUCLEOTIDES; Subject Term: DISSOCIATION (Chemistry); Subject Term: PHOSPHATES; Author-Supplied Keyword: GDP-dissociation; Author-Supplied Keyword: GTP binding; Author-Supplied Keyword: Guanine nucleotide exchange; Author-Supplied Keyword: Reaction mechanism; Author-Supplied Keyword: Rho GTPases; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.03.179
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17021106&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klamt, Fabio
AU - Shaeter, Emily
T1 - Taurine Chloramine, an Oxidant Derived from Neutrophils, Induces Apoptosis in Human B Lymphoma Cells through Mitochondrial Damage.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/06/03/
VL - 280
IS - 22
M3 - Article
SP - 21346
EP - 21352
SN - 00219258
AB - Taurine chloramine (TN-Cl) is one of the most abundant compounds generated by activated neutrophils. In contrast to HOCl, which causes necrosis, TN-Cl is a potent inducer of apoptosis in tumor cells. Here we show that the apoptosis induced by TN-Cl in human B lymphoma cells is dependent upon oxidant-mediated mitochondrial damage, a decrease in mitochondrial membrane potential, and caspase-9 activation. Further, we show that TN-Cl is taken up into the cells and is concentrated in the mitochondria, where it induces opening of the permeability transition pore and mitochondrial swelling. Identical activity is seen upon treatment of isolated mitochondria with TN-Cl and is blocked by the permeability transition pore inhibitors bongkrekic acid and cyclosporin A, as well as by the sulfhydryl-reducing agent tris(2-carboxyethyl)-phosphine. The data suggest that TN-Cl causes apoptosis through direct damage to the mitochondria. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER cells
KW - APOPTOSIS
KW - NEUTROPHILS
KW - OXIDIZING agents
KW - CELL death
KW - MITOCHONDRIA
KW - TUMORS
N1 - Accession Number: 17303866; Klamt, Fabio 1,2 Shaeter, Emily 1; Email Address: emily@shacter@fda.gov; Affiliation: 1: Laboratory of Biochemistry, Division of Therapeutic Proteins, Center of Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Department of Biology, Lutheran University of Brazil (ULBRA), Canoas, RS Brazil; Source Info: 6/3/2005, Vol. 280 Issue 22, p21346; Subject Term: CANCER cells; Subject Term: APOPTOSIS; Subject Term: NEUTROPHILS; Subject Term: OXIDIZING agents; Subject Term: CELL death; Subject Term: MITOCHONDRIA; Subject Term: TUMORS; Number of Pages: 7p; Illustrations: 4 Diagrams, 11 Graphs; Document Type: Article
L3 - 10.1074/jbc.M501170200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17303866&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sievert, J.
AU - Lackovic, M.
AU - Becker, A.
AU - Lew, D. H.
AU - Morrissey, B.
AU - Blondell, J.
AU - Kim-Jung, L. Y.
AU - Pitts, M. R.
AU - Holquist, C. A.
AU - Petersen, A. M.
AU - Alonso-Katzowitz, J. S.
AU - Calvert, G. M.
T1 - Unintentional Topical Lindane Ingestions -- United States, 1998--2003.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/06/03/
VL - 54
IS - 21
M3 - Article
SP - 533
EP - 535
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes the results of an analysis on the unintentional topical lindane ingestions in the U.S. from 1998-2003. Information on the two treatments for pediculosis approved by the U.S. Food & Drug Administration; Common human parasitic infestations; Definition of lindane.
KW - LINDANE
KW - INGESTION
KW - INSECTICIDES
KW - PEDICULOSIS
KW - UNITED States
N1 - Accession Number: 17220872; Sievert, J. 1 Lackovic, M. 2 Becker, A. 3 Lew, D. H. 4 Morrissey, B. 5 Blondell, J. 6 Kim-Jung, L. Y. Pitts, M. R. Holquist, C. A. Petersen, A. M. 7 Alonso-Katzowitz, J. S. 7 Calvert, G. M. 7; Affiliation: 1: Texas Dept of State Health Svcs 2: Louisiana Dept of Health and Hospitals 3: Florida Dept of Health 4: Oregon Dept of Human Svcs 5: Washington State Dept of Health 6: Office of Pesticide Programs, US Environmental Protection Agency 7: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 6/3/2005, Vol. 54 Issue 21, p533; Subject Term: LINDANE; Subject Term: INGESTION; Subject Term: INSECTICIDES; Subject Term: PEDICULOSIS; Subject Term: UNITED States; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nam, Eunjoo
AU - Lee, Seung Min
AU - Koh, Seong Eun
AU - Joo, Wan Seok
AU - Maeng, Sungho
AU - Im, Heh In
AU - Kim, Yong Sik
T1 - Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum
JO - Brain Research
JF - Brain Research
Y1 - 2005/06/07/
VL - 1046
IS - 1/2
M3 - Article
SP - 90
EP - 96
SN - 00068993
AB - Abstract: In this study, the protective effects of melatonin were evaluated against 3-nitropropionic acid (3-NP)-induced striatal neuronal damage in rats. Lesions were induced in the right striatum of Sprague–Dawley rats by stereotaxic injection with 3-NP and melatonin was intraperitoneally administered both 30 min before and 60 min after 3-NP injection. And rats continuously received melatonin daily for 3 days. As indicators of oxidative damage, lipid peroxidation and protein oxidation in the lesioned striatum were measured at 1 day after 3-NP injection. Levels of malondialdehyde (MDA) and protein carbonyl were significantly increased by 3-NP injection, but reduced in the melatonin-treated rats. Four days post-lesion, large lesions and extensive neuronal damage were produced in the 3-NP-injected striata, as revealed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. In addition, marked ipsilateral rotational behavior following apomorphine challenge and a decrease of dopamine content in the lesioned striatum were observed in the 3-NP-injected rats. However, melatonin treatment significantly attenuated the 3-NP-induced neuronal damage, reduced the degree of asymmetric rotational behavior, and restored the dopamine level in the lesioned striatum. The present results indicate that melatonin effectively protects against the neuronal damage caused by 3-NP in vivo and that the neuroprotective effects of melatonin may be related to antioxidant action. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROPLASTICITY
KW - MELATONIN
KW - RATS
KW - ANTIOXIDANTS
KW - 3-Nitropropionic acid (3-NP)
KW - Antioxidant
KW - Melatonin
KW - Neuronal damage
KW - Oxidative stress
N1 - Accession Number: 17960671; Nam, Eunjoo 1 Lee, Seung Min 1 Koh, Seong Eun 2 Joo, Wan Seok 3 Maeng, Sungho 1 Im, Heh In 1 Kim, Yong Sik 1; Email Address: kimysu@plaza.snu.ac.kr; Affiliation: 1: Department of Pharmacology, College of Medicine and Neuroscience Research Institute of Medical Research Center, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea 2: Department of Rehabilitation Medicine, College of Medicine, Konkuk University, Seoul 143-914, Korea 3: Division of Biologics Evaluation, Korea Food and Drug Administration, Seoul 122-704, Korea; Source Info: Jun2005, Vol. 1046 Issue 1/2, p90; Subject Term: NEUROPLASTICITY; Subject Term: MELATONIN; Subject Term: RATS; Subject Term: ANTIOXIDANTS; Author-Supplied Keyword: 3-Nitropropionic acid (3-NP); Author-Supplied Keyword: Antioxidant; Author-Supplied Keyword: Melatonin; Author-Supplied Keyword: Neuronal damage; Author-Supplied Keyword: Oxidative stress; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.brainres.2005.03.053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hubbs, Ann
AU - Greskevitch, Mark
AU - Kuempel, Eileen
AU - Suarez, Fernando
AU - Toraason, Mark
T1 - Abrasive Blasting Agents: Designing Studies to Evaluate Relative Risk.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/06/11/
VL - 68
IS - 11/12
M3 - Article
SP - 999
EP - 1016
SN - 15287394
AB - Workers exposed to respirable crystalline silica used in abrasive blasting are at increased risk of developing a debilitating and often fatal fibrotic lung disease called silicosis. The National Institute for Occupational Safety and Health (NIOSH) recommends that silica sand be prohibited as abrasive blasting material and that less hazardous materials be used in blasting operations. However, data are needed on the relative risks associated with exposure to abrasive blasting materials other than silica. NIOSH has completed acute studies in rats (Hubbs et al., 2001; Porter et al., 2002). To provide dose-response data applicable to making recommendation for occupational exposure limits, NIOSH has collaborated with the National Toxicology Program (NTP) to design longer term studies with silica substitutes. For risk assessment purposes, selected doses will include concentrations that are relevant to human exposures. Rat lung burdens achieved should be comparable to those estimated in humans with working lifetime exposures, even if this results in “overloading” doses in rats. To quantify both dose and response, retained particle burdens in the lungs and lung-associated lymph nodes will be measured, as well as biochemical and pathological indices of pulmonary response. This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - SILICA sand
KW - SILICOSIS
KW - LUNGS -- Dust diseases
KW - TOXICOLOGY -- Dose-response relationship
KW - RATS as laboratory animals
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 17321614; Hubbs, Ann 1; Email Address: AHubbs@cdc.gov Greskevitch, Mark 1 Kuempel, Eileen 2 Suarez, Fernando 3 Toraason, Mark 2; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; Source Info: 2005, Vol. 68 Issue 11/12, p999; Subject Term: RISK assessment; Subject Term: SILICA sand; Subject Term: SILICOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: TOXICOLOGY -- Dose-response relationship; Subject Term: RATS as laboratory animals; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 18p; Document Type: Article
L3 - 10.1080/15287390590912612
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Lavin, Roberta Proffitt
T1 - … nurses need to be professionals.
JO - Modern Healthcare
JF - Modern Healthcare
Y1 - 2005/06/13/
VL - 35
IS - 24
M3 - Letter
SP - 21
EP - 21
PB - Crain Communications Inc. (MI)
SN - 01607480
AB - Presents a letter to the editor about nursing unions.
KW - LETTERS to the editor
KW - NURSING
N1 - Accession Number: 17415345; Lavin, Roberta Proffitt 1; Affiliation: 1: Captain, U.S. Public Health Service, Washington; Source Info: 6/13/2005, Vol. 35 Issue 24, p21; Subject Term: LETTERS to the editor; Subject Term: NURSING; Number of Pages: 1/8p; Document Type: Letter; Full Text Word Count: 126
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biagini, R. E.
AU - Sammons, D. L.
AU - Smith, J. P.
AU - MacKenzie, B. A.
AU - Striley, C. A. F.
AU - Robertson, S. A.
AU - Snawder, J. E.
AU - Quinn, C. P.
T1 - Simultaneous measurement of specific serum IgG responses to five select agents.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2005/06/15/
VL - 382
IS - 4
M3 - Article
SP - 1027
EP - 1034
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Select Agents are defined by CDC and the USDA Animal and Plant Health Inspection Service (APHIS) as biological agents or toxins deemed a threat to public, animal, or plant health, or to animal or plant products. They are classified on the basis of their ease of dissemination, mortality/morbidity rate, and potential for social disruption. A subset of these agents includes Bacillus anthracis, Yersinia pestis, Francisella tularensis, ricin toxin (RT), and staphylococcal enterotoxin B (SEB). Infection or intoxication with these agents has been shown to elicit an antigen-specific serum IgG response. We describe a fluorescent covalent microsphere immunoassay (FCMIA) for measurement of specific IgG antibodies to seven different antigens from five different select agents; B. anthracis [protective antigen (PA) and lethal factor (LF)], Y. pestis (F1 and V antigens), F. tularensis, RT and SEB simultaneously in human B. anthracis vaccinee sera (containing anti-PA and anti-LF IgG) which had been spiked with animal specific IgG antibodies to the other select agents. Inter-assay and intra-assay coefficients of variation were 6.5 and 13.4%, respectively ( N=4). There were no significant differences ( P>0.70) between assay responses when the assays were performed individually or multiplexed. When the observed versus expected interpolated concentrations were compared, highly linear relationships were observed ( r2 values from 0.981 to 0.999, P<0.001). Minimum detectable concentrations (MDC) ranged from 0.3 ng mL−1 ( Y. pestis F1) to 300 ng mL−1 (RT). Finally, the curves showed responses were linear for most analytes from their MDC to 125 (SEB) to 1,300 ( Y. pestis F1)×their MDC. These data indicate that multiplexed FCMIA is a sensitive and accurate method for simultaneous measurement of specific IgG in serum to CDC select agents and may be of value in screening either decontamination workers or the general population for exposure to/infection with these agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXINS
KW - BACILLUS anthracis
KW - YERSINIA pestis
KW - FRANCISELLA tularensis
KW - RICIN
KW - STAPHYLOCOCCAL diseases
KW - IMMUNOGLOBULINS
KW - Anthrax
KW - Plague
KW - Ricin
KW - Staphylococcal enterotoxin B
KW - Tularemia
N1 - Accession Number: 17434196; Biagini, R. E. 1; Email Address: reb4@cdc.gov Sammons, D. L. 1 Smith, J. P. 1 MacKenzie, B. A. 1 Striley, C. A. F. 1 Robertson, S. A. 1 Snawder, J. E. 1 Quinn, C. P. 2; Affiliation: 1: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Microbial Pathogenesis and Immune Response (MPIR) Laboratory, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA 30333, USA; Source Info: Jun2005, Vol. 382 Issue 4, p1027; Subject Term: TOXINS; Subject Term: BACILLUS anthracis; Subject Term: YERSINIA pestis; Subject Term: FRANCISELLA tularensis; Subject Term: RICIN; Subject Term: STAPHYLOCOCCAL diseases; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: Anthrax; Author-Supplied Keyword: Plague; Author-Supplied Keyword: Ricin; Author-Supplied Keyword: Staphylococcal enterotoxin B; Author-Supplied Keyword: Tularemia; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1007/s00216-005-3204-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brinker, Allen
AU - He, Ruyi
AU - Desai, Mehul
AU - Gelperin, Kate
AU - Robie-Suh, Kathy
T1 - Safety of Ximelagatran.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/06/15/
VL - 293
IS - 23
M3 - Article
SP - 2859
EP - 2860
SN - 00987484
AB - Presents a letter to the editor in response to an article about the safety of ximelagatran that appeared in a previous issue of "The Journal of the American Medical Association."
KW - LETTERS to the editor
KW - MEDICINE
KW - Pulmonary Embolism
KW - Thromboembolism
KW - Venous Thrombosis
KW - Vitamin K Antagonists
KW - Ximelagatran
N1 - Accession Number: 17338056; Brinker, Allen 1 He, Ruyi 1 Desai, Mehul 1 Gelperin, Kate 1 Robie-Suh, Kathy 1; Email Address: robiesuh@cder.fda.gov; Affiliation: 1: Office of New Drugs and Office of Drug Safety, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland; Source Info: 6/15/2005, Vol. 293 Issue 23, p2859; Subject Term: LETTERS to the editor; Subject Term: MEDICINE; Author-Supplied Keyword: Pulmonary Embolism; Author-Supplied Keyword: Thromboembolism; Author-Supplied Keyword: Venous Thrombosis; Author-Supplied Keyword: Vitamin K Antagonists; Author-Supplied Keyword: Ximelagatran; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Y.-H. Huang, Claire
AU - Silengo, Shawn J.
AU - Whiteman, Melissa C.
AU - Kinney, Richard M.
T1 - Chimeric Dengue 2 PDK-53/West Nile NY99 Viruses Retain the Phenotypic Attenuation Markers of the Candidate PDK-53 Vaccine Virus and Protect Mice against Lethal Challenge with West Nile Virus.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/06/15/
VL - 79
IS - 12
M3 - Article
SP - 7300
EP - 7310
SN - 0022538X
AB - Chimeric dengue serotype 2/West Nile (D2/WN) viruses expressing prM-E of WN NY99 virus in the genetic background of wild-type D2 16681 virus and two candidate D2 PDK-53 vaccine variants (PDK53-E and PDK53-V) were engineered. The viability of the D2/WN viruses required incorporation of the WN virus-specific signal sequence for prM. Introduction of two mutations at M-58 and E-191 in the chimeric cDNA clones further improved the viability of the chimeras constructed in all three D2 carriers. Two D2/WN chimeras (D2/WN-E2 and -V2) engineered in the backbone of the PDK53-E and -V viruses retained all of the PDK-53 vaccine characteristic phenotypic markers of attenuation and were immunogenic in mice and protected mice from a high-dose 107 PFU challenge with wild-type WN NY99 virus. This report further supports application of the genetic background of the D2 PDK-53 virus as a carrier for development of live-attenuated, chimeric flavivirus vaccines in general and the development of a chimeric D2/WN vaccine virus against WN disease in particular. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE
KW - ARBOVIRUS diseases
KW - VACCINES
KW - WEST Nile virus
KW - VIROLOGY
N1 - Accession Number: 17276226; Y.-H. Huang, Claire 1; Email Address: CHuang1@cdc.gov Silengo, Shawn J. 1 Whiteman, Melissa C. 1 Kinney, Richard M. 1; Affiliation: 1: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado; Source Info: Jun2005, Vol. 79 Issue 12, p7300; Subject Term: DENGUE; Subject Term: ARBOVIRUS diseases; Subject Term: VACCINES; Subject Term: WEST Nile virus; Subject Term: VIROLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1128/JVL79.12.7300-7310.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petrakova, Olga
AU - Volkova, Eugenia
AU - Gorchakov, Rodion
AU - Paessler, Slobodan
AU - Kinney, Richard M.
AU - Frolov, Ilya
T1 - Noncytopathic Replication of Venezuelan Equine Encephalitis Virus and Eastern Equine Encephalitis Virus Replicons in Mammalian Cells.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/06/15/
VL - 79
IS - 12
M3 - Article
SP - 7597
EP - 7608
SN - 0022538X
AB - Venezuelan equine encephalitis (VEE) and eastern equine encephalitis (EEE) viruses are important, naturally emerging zoonotic viruses. They are significant human and equine pathogens which still pose a serious public health threat. Both VEE and EEE cause chronic infection in mosquitoes and persistent or chronic infection in mosquito-derived cell lines. In contrast, vertebrate hosts infected with either virus develop an acute infection with high-titer viremia and encephalitis, followed by host death or virus clearance by the immune system. Accordingly, EEE and VEE infection in vertebrate cell lines is highly cytopathic. To further understand the pathogenesis of alphaviruses on molecular and cellular levels, we designed EEE- and VEE-based replicons and investigated their replication and their ability to generate cytopathic effect (CPE) and to interfere with other viral infections. VEE and EEE replicons appeared to be less cytopathic than Sindbis virus-based constructs that we designed in our previous research and readily established persistent replication in BHK-21 cells. VEE replicons required additional mutations in the 5' untranslated region and nsP2 or nsP3 genes to further reduce cytopathicity and to become capable of persisting in cells with no defects in alpha/beta interferon production or signaling. The results indicated that alphaviruses strongly differ in virus-host cell interactions, and the ability to cause CPE in tissue culture does not necessarily correlate with pathogenesis and strongly depends on the sequence of viral nonstructural proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VENEZUELAN equine encephalomyelitis
KW - EASTERN equine encephalomyelitis
KW - ENCEPHALITIS
KW - VIRUS diseases
KW - VIRUSES
KW - VIROLOGY
N1 - Accession Number: 17276254; Petrakova, Olga 1 Volkova, Eugenia 1 Gorchakov, Rodion 1 Paessler, Slobodan 2 Kinney, Richard M. 3 Frolov, Ilya 1; Email Address: ivfrolov@utmb.edu; Affiliation: 1: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 2: Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 3: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S., Department of Health and Human Services, Fort Collins, Colorado; Source Info: Jun2005, Vol. 79 Issue 12, p7597; Subject Term: VENEZUELAN equine encephalomyelitis; Subject Term: EASTERN equine encephalomyelitis; Subject Term: ENCEPHALITIS; Subject Term: VIRUS diseases; Subject Term: VIRUSES; Subject Term: VIROLOGY; Number of Pages: 12p; Illustrations: 1 Color Photograph, 5 Diagrams, 9 Graphs; Document Type: Article
L3 - 10.1128/J VI.79.12.7597-7608.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chakrabarti, Kausik
AU - Rong Lin
AU - Schiller, Noraisha I.
AU - Yanping Wang
AU - Koubi, David
AU - Ying-Xin Fan
AU - Rudkin, Brian B.
AU - Johnson, Gibbes R.
AU - Schiller, Martin R.
T1 - Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2005/06/15/
VL - 25
IS - 12
M3 - Article
SP - 5106
EP - 5118
SN - 02707306
AB - Kalirin is a multidomain guanine nucleotide exchange factor (GEF) that activates Rho proteins, inducing cytoskeletal rearrangement in neurons. Although much is known about the effects of Kalirin on Rho GTPases and neuronal morphology, little is known about the association of Kalirin with the receptor/signaling systems that affect neuronal morphology. Our experiments demonstrate that Kalirin binds to and colocalizes with the TrkA neurotrophin receptor in neurons. In PC12 cells, inhibition of Kalirin expression using antisense RNA decreased nerve growth factor (NGF)-induced TrkA autophosphorylation and process extension. Kalirin overexpression potentiated neurotrophin-stimulated TrkA autophosphorylation and neurite outgrowth in PC12 cells at a low concentration of NGF. Furthermore, elevated Kalirin expression resulted in catalytic activation of TrkA, as demonstrated by in vitro kinase assays and increased NGF-stimulated cellular activation of Rac, Mek, and CREB. Domain mapping demonstrated that the N-terminal Kalirin pleckstrin homology domain mediates the interaction with TrkA. The effects of Kalirin on TrkA provide a molecular basis for the requirement of Kalirin in process extension from PC12 cells and for previously observed effects on axonal extension and dendritic maintenance. The interaction of TrkA with the pleckstrin homology domain of Kalirin may be one example of a general mechanism whereby receptor/Rho GEF pairings play an important role in receptor tyrosine kinase activation and signal transduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHO GTPases
KW - CELLULAR signal transduction
KW - G proteins
KW - NERVE Growth Factor
KW - PROTEIN-tyrosine kinase
KW - CELL receptors
KW - NEURONS
KW - PROTEIN binding
N1 - Accession Number: 17363962; Chakrabarti, Kausik 1 Rong Lin 1 Schiller, Noraisha I. 1 Yanping Wang 1 Koubi, David 2 Ying-Xin Fan 3 Rudkin, Brian B. 2 Johnson, Gibbes R. 3 Schiller, Martin R. 1; Email Address: schiller@nso.uche.edu; Affiliation: 1: University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut 06030-4301 2: Laboratoire de Biologie Moleculaire de la Cellule, UMR 5161 CNRS, INRA U1237, Ecole Normale Supérieure de Lyon, IFR 128 "BioSciences Lyon-Gerland," 69364 Lyon ceder 07, France 3: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Jun2005, Vol. 25 Issue 12, p5106; Subject Term: RHO GTPases; Subject Term: CELLULAR signal transduction; Subject Term: G proteins; Subject Term: NERVE Growth Factor; Subject Term: PROTEIN-tyrosine kinase; Subject Term: CELL receptors; Subject Term: NEURONS; Subject Term: PROTEIN binding; Number of Pages: 8p; Document Type: Article
L3 - 10.1128/MCB.25.12.5106-5118.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Richard A Deyo
AU - Darryl T Gray
AU - William Kreuter
AU - Sohail Mirza
AU - Brook I Martin
T1 - United States Trends in Lumbar Fusion Surgery for Degenerative Conditions.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2005/06/15/
VL - 30
IS - 12
M3 - Article
SP - 1441
EP - 1445
SN - 03622436
AB - STUDY DESIGN.: Retrospective cohort study using national sample administrative data. OBJECTIVES.: To determine if lumbar fusion rates increased in the 1990s and to compare lumbar fusion rates with those of other major musculoskeletal procedures. SUMMARY OF BACKGROUND DATA.: Previous studies found that lumbar fusion rates rose more rapidly during the 1980s than did other types of lumbar surgery. METHODS.: We used the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1988 through 2001 to examine trends. U.S. Census data were used for calculating age and sex-adjusted population-based rates. We excluded patients with vertebral fractures, cancer, or infection. RESULTS.: In 2001, over 122,000 lumbar fusions were performed nationwide for degenerative conditions. This represented a 220% increase from 1990 in fusions per 100,000. The increase accelerated after 1996, when fusion cages were approved. From 1996 to 2001, the number of lumbar fusions increased 113%, compared with 13 to 15% for hip replacement and knee arthroplasty. Rates of lumbar fusion rose most rapidly among patients aged 60 and above. The proportion of lumbar operations involving a fusion increased for all diagnoses. CONCLUSIONS.: Lumbar fusion rates rose even more rapidly in the 90s than in the 80s. The most rapid increases followed the approval of new surgical implants and were much greater than increases in other major orthopedic procedures. The most rapid increases in fusion rates were among adults aged 60 and above. These increases were not associated with reports of clarified indications or improved efficacy, suggesting a need for better data on the efficacy of various fusion techniques for various indications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Spine (03622436) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASTIC surgery
KW - STIFLE joint
KW - ARTIFICIAL implants
KW - ARTHROPLASTY
N1 - Accession Number: 18498787; Richard A Deyo 1 Darryl T Gray William Kreuter Sohail Mirza Brook I Martin; Affiliation: 1: From the *Departments of Medicine, Health Services, Orthopaedics and Sports Medicine, and the Center for Cost and Outcomes Research, University of Washington, Seattle, Washington; and the Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, Maryland.; Source Info: Jun2005, Vol. 30 Issue 12, p1441; Subject Term: PLASTIC surgery; Subject Term: STIFLE joint; Subject Term: ARTIFICIAL implants; Subject Term: ARTHROPLASTY; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Weila
AU - Merchlinsky, Michael
AU - Inman, John
AU - Golding, Basil
T1 - Identification of a novel immunodominant cytotoxic T lymphocyte epitope derived from human factor VIII in a murine model of hemophilia A
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2005/06/15/
VL - 116
IS - 4
M3 - Article
SP - 335
EP - 344
SN - 00493848
AB - Abstract: Gene therapy of hemophilia A could be complicated by the development of immune responses against the vector as well as the Factor VIII (FVIII) transgene. Previous efforts have been focused on identifying FVIII inhibitor antibody epitopes, whereas the cytotoxic T lymphocyte (CTL) epitopes have not been characterized. CTL would kill cells expressing such epitopes and thus limit the efficacy of gene therapy. To investigate CTL responses against human FVIII in a mouse model of hemophilia A, a computer algorithm program (BIMAS) was employed to predict CTL epitopes of human FVIII. The potential binding of these predicted peptides to MHC class I Kb was evaluated in a TAP-deficient cell line. When recombinant vaccinia virus expressing B domain-deleted human FVIII (vv-FVIII) was used to immunize E16 hemophilia A mice, a specific CTL response against FVIII152–159 was generated. In contrast, a CTL response to four other FVIII peptides was not detected. Therefore, FVIII152–159 represents a dominant CTL epitope. Identification of this epitope raises the possibility that CTL response to FVIII gene-transduced cells can be diminished by deliberatively mutating the dominant CTL epitope while retaining the biologic function of FVIII for hemophilia A gene therapy. [Copyright &y& Elsevier]
AB - Copyright of Thrombosis Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE therapy
KW - GENETIC engineering
KW - HEMOPHILIA
KW - THERAPEUTICS
KW - Animal model
KW - CTL epitope
KW - cytotoxic T lymphocyte ( CTL )
KW - Factor VIII
KW - Factor VIII ( FVIII )
KW - Gene therapy
KW - Heat-killed Brucella abortus ( HKBA )
KW - Hemophilia A
KW - Toll-like receptor ( TLR )
KW - Transporter of antigenic peptides ( TAP )
N1 - Accession Number: 18156580; Wang, Weila 1; Email Address: wangw@cber.fda.gov Merchlinsky, Michael 2 Inman, John 3 Golding, Basil 1; Affiliation: 1: Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA 2: Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA 3: National Institute of Allergy and Infectious Diseases, 29 Lincoln Drive, Bethesda, MD 20892, USA; Source Info: Jun2005, Vol. 116 Issue 4, p335; Subject Term: GENE therapy; Subject Term: GENETIC engineering; Subject Term: HEMOPHILIA; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Animal model; Author-Supplied Keyword: CTL epitope; Author-Supplied Keyword: cytotoxic T lymphocyte ( CTL ); Author-Supplied Keyword: Factor VIII; Author-Supplied Keyword: Factor VIII ( FVIII ); Author-Supplied Keyword: Gene therapy; Author-Supplied Keyword: Heat-killed Brucella abortus ( HKBA ); Author-Supplied Keyword: Hemophilia A; Author-Supplied Keyword: Toll-like receptor ( TLR ); Author-Supplied Keyword: Transporter of antigenic peptides ( TAP ); NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.thromres.2004.12.011
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Agol, Vadim I.
AU - Chumakov, Konstantin
AU - Ehrenfeld, Ellie
AU - Wimmer, Eckard
T1 - Don't drop current vaccine until we have new ones.
JO - Nature
JF - Nature
Y1 - 2005/06/16/
VL - 435
IS - 7044
M3 - Letter
SP - 881
EP - 881
PB - Nature Publishing Group
SN - 00280836
AB - Presents a letter to the editor on new poliovirus vaccines.
KW - LETTERS to the editor
KW - VACCINATION
N1 - Accession Number: 17348653; Agol, Vadim I. 1 Chumakov, Konstantin 2 Ehrenfeld, Ellie 3 Wimmer, Eckard 4; Affiliation: 1: Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow Region 142782, Russia. 2: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, USA. 3: National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA. 4: Department of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, New York, USA.; Source Info: 6/16/2005, Vol. 435 Issue 7044, p881; Subject Term: LETTERS to the editor; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Letter
L3 - 10.1038/435881b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17348653&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Przybyla-Zawislak, Beata D.
AU - Kim, Chung S.
AU - Ali, Syed F.
AU - Slikker, William
AU - Binienda, Zbigniew K.
T1 - The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2005/06/17/
VL - 381
IS - 3
M3 - Article
SP - 354
EP - 357
SN - 03043940
AB - Abstract: The inhibitor of mitochondrial enzyme succinate dehydrogenase, 3-nitropropionic acid (3-NPA), induces cellular energy deficit followed by oxidative stress, secondary excitotoxicity and neuronal degeneration. The fast activation of Jun and Fos proteins and other proteins encoding inducible transcription factors (ITFs) occurs in most tissues upon exposure to a variety of stressors including exposure to mitochondrial inhibitors. However, the consequences of this activation can differ dramatically in different organs. For example, while activation of the same ITFs may lead to apoptosis and necrosis in neurons it may stimulate liver regeneration. Here, we report the alterations in mRNAs levels of c-Fos, JunB, and Krox20 proteins induced in the rat brain and liver by the acute exposure to 3-NPA at 30mg/kg, s.c. While the increase of c-fos transcripts was observed in both the hippocampus and liver, the junb transcript increased in the hippocampus but decreased in the liver. No changes were observed in krox-20 mRNA in the hippocampus. Interestingly, there was a large variation in krox-20 mRNA levels in the liver among animals within the same experimental group. In conclusion, out of the three ITFs transcripts examined here junb may activate different pathways depending on the tissue as indicated by differential responses to mitochondrial inhibition in the hippocampus and liver. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEHYDROGENASES
KW - LIMBIC system
KW - MESSENGER RNA
KW - OXIDATIVE stress
KW - 3-Nitropropionic acid
KW - c-fos
KW - Hippocampus
KW - junb
KW - krox-20
KW - Liver
KW - Rat
N1 - Accession Number: 17852733; Przybyla-Zawislak, Beata D. 1; Email Address: bzawislak@nctr.fda.gov Kim, Chung S. 2 Ali, Syed F. 1 Slikker, William 1 Binienda, Zbigniew K. 1; Affiliation: 1: Division of Neurotoxicology, FDA/National Center for Toxicological Research (NCTR), 3900 NCTR Road, Jefferson, AR 72079-9502, USA 2: Division of Toxicology, FDA/CFSAN, Laurel, MD, USA; Source Info: Jun2005, Vol. 381 Issue 3, p354; Subject Term: DEHYDROGENASES; Subject Term: LIMBIC system; Subject Term: MESSENGER RNA; Subject Term: OXIDATIVE stress; Author-Supplied Keyword: 3-Nitropropionic acid; Author-Supplied Keyword: c-fos; Author-Supplied Keyword: Hippocampus; Author-Supplied Keyword: junb; Author-Supplied Keyword: krox-20; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Rat; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neulet.2005.02.049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bae, S.
AU - Famoye, F.
AU - Wulu, J.T.
AU - Bartolucci, A.A.
AU - Singh, K.P.
T1 - A rich family of generalized Poisson regression models with applications
JO - Mathematics & Computers in Simulation
JF - Mathematics & Computers in Simulation
Y1 - 2005/06/20/
VL - 69
IS - 1/2
M3 - Article
SP - 4
EP - 11
SN - 03784754
AB - Abstract: The Poisson regression (PR) model is inappropriate for modeling over- or under-dispersed (or inflated) data. Several generalizations of PR model have been proposed for modeling such data. In this paper, a rich family of generalized Poisson regression (GPR) models is reviewed in detail. The family has a wide range of applications in various disciplines including agriculture, econometrics, patent applications, species abundance, medicine, and use of recreational facilities. For illustrating the usefulness of the family, several applications with different situations are given. For example, hospital discharge counts are modeled using GPR and other generalized models, in which the applied models show that household size, education, and income are positively related to diagnosis-related groups (DRGs) hospital discharges. One of the advantages of using the family is that it lets data determine which model is appropriate for a given situation. It is expected that the results discussed in the paper would enhance our understanding of various forms of count data originating from primary health care facilities and medical domains. [Copyright &y& Elsevier]
AB - Copyright of Mathematics & Computers in Simulation is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMPTION (Economics) -- Mathematical models
KW - REGRESSION analysis
KW - COMMUNITY health services
KW - MEDICAL care
KW - Dispersion
KW - Hospital discharge
KW - Negative binomial regression
KW - Poisson regression
KW - Sex partners
N1 - Accession Number: 17952205; Bae, S. 1 Famoye, F. 2 Wulu, J.T. 3 Bartolucci, A.A. 4 Singh, K.P. 1; Email Address: ksingh@hsc.unt.edu; Affiliation: 1: Department of Biostatistics, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA 2: Department of Mathematics, Central Michigan University, Mount Pleasant, MI 48859, USA 3: Bureau of Primary Care, Health Resources and Services Administration, Department of Health and Human Services, Bethesda, MD 20814, USA 4: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294-2699, USA; Source Info: Jun2005, Vol. 69 Issue 1/2, p4; Subject Term: CONSUMPTION (Economics) -- Mathematical models; Subject Term: REGRESSION analysis; Subject Term: COMMUNITY health services; Subject Term: MEDICAL care; Author-Supplied Keyword: Dispersion; Author-Supplied Keyword: Hospital discharge; Author-Supplied Keyword: Negative binomial regression; Author-Supplied Keyword: Poisson regression; Author-Supplied Keyword: Sex partners; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.matcom.2005.02.026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17952205&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hartmann, Faye A.
AU - White, David G.
AU - West, Susan E.H.
AU - Walker, Robert D.
AU - DeBoer, Douglas J.
T1 - Molecular characterization of Staphylococcus intermedius carriage by healthy dogs and comparison of antimicrobial susceptibility patterns to isolates from dogs with pyoderma
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2005/06/20/
VL - 108
IS - 1/2
M3 - Article
SP - 119
EP - 131
SN - 03781135
AB - Abstract: We conducted an epidemiological study of Staphylococcus intermedius using arbitrarily primed PCR (AP-PCR) and antibiograms. One hundred and twenty-five S. intermedius isolates were recovered from the oral cavity and/or cranial hair coat of healthy dogs enrolled in a pet therapy program. Commensal S. intermedius was cultured from 32% of the oral cavity cultures and 13% of the cranial hair coat cultures. We characterized the colonization of the dogs as transient, intermittent, or persistent. For dogs characterized as persistently colonized, 73% of the isolates came from the oral cavity. These isolates were also genotyped by AP-PCR. A single major AP-PCR type was observed in 91% of the dogs (n =22); minor variations were frequently observed in these major types. Antibiograms of these commensal isolates were compared to antibiograms from 97 historical clinical isolates (1988–1992) obtained from cases of canine pyoderma. Resistance was most often observed to penicillin (64% and 55%) and tetracycline (38% and 38%) among the commensal and clinical isolates, respectively. The commensal isolates were significantly less resistant to erythromycin, clarithromycin, clindamycin, and trimethoprim/sulfamethoxazole. Our data suggests that differences in both genotype and antimicrobial susceptibility phenotypes exist among S. intermedius strains isolated from different anatomic sites from the same dog and supports the opportunistic nature of S. intermedius in canine infections. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBACTERIAL agents
KW - BETA lactam antibiotics
KW - GENETIC polymorphisms
KW - CO-trimoxazole
KW - Antimicrobial resistance
KW - Pyoderma
KW - Staphylococcus intermedius
N1 - Accession Number: 18512786; Hartmann, Faye A. 1; Email Address: hartmannf@svm.vetmed.wisc.edu White, David G. 2 West, Susan E.H. 3 Walker, Robert D. 2 DeBoer, Douglas J. 4; Affiliation: 1: Veterinary Medical Teaching Hospital, School of Veterinary Medicine, Clinical Pathology Laboratory, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA 2: United States Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Rd., Laurel, MD 20708, USA 3: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA 4: Department of Medicine, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA; Source Info: Jun2005, Vol. 108 Issue 1/2, p119; Subject Term: ANTIBACTERIAL agents; Subject Term: BETA lactam antibiotics; Subject Term: GENETIC polymorphisms; Subject Term: CO-trimoxazole; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Pyoderma; Author-Supplied Keyword: Staphylococcus intermedius; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.vetmic.2005.03.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martella, V.
AU - Ciarlet, M.
AU - Baselga, R.
AU - Arista, S.
AU - Elia, G.
AU - Lorusso, E.
AU - Bányai, K.
AU - Terio, V.
AU - Madio, A.
AU - Ruggeri, F.M.
AU - Falcone, E.
AU - Camero, M.
AU - Decaro, N.
AU - Buonavoglia, C.
T1 - Sequence analysis of the VP7 and VP4 genes identifies a novel VP7 gene allele of porcine rotaviruses, sharing a common evolutionary origin with human G2 rotaviruses
JO - Virology
JF - Virology
Y1 - 2005/06/20/
VL - 337
IS - 1
M3 - Article
SP - 111
EP - 123
SN - 00426822
AB - Abstract: During an epidemiological survey encompassing several porcine herds in Saragoza, Spain, the VP7 and VP4 of a rotavirus-positive sample, 34461-4, could not be predicted by using multiple sets of G- and P-type-specific primers. Sequence analysis of the VP7 gene revealed a low amino acid (aa) identity with those of well-established G serotypes, ranging between 58.33% and 88.88%, with the highest identity being to human G2 rotaviruses. Analysis of the VP4 gene revealed a P[23] VP4 specificity, as its VP8* aa sequence was 95.9% identical to that of the P14[23],G5 porcine strain A34, while analysis of the VP6 indicated a genogroup I, that is predictive of subgroup I specificity. Analysis of the 10th and 11th RNA segments revealed close identity to strains of porcine and human origin, respectively. The relatively low overall aa sequence conservation (<89% aa) to G2 human rotaviruses, the lack of N-glycosylation sites that are usually highly conserved in G2 rotaviruses, and the presence of several amino acid substitutions in the major antigenic hypervariable regions hampered an unambiguous classification of the porcine strain 34461-4 as G2 serotype on the basis of sequence analysis alone. The identification of a borderline, G2-like, VP7 gene allele in pigs, while reinforcing the hypotheses of a tight relationship in the evolution of human and animal rotaviruses, provides additional evidence for the wide genetic/antigenic diversity of group A rotaviruses. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - COMPARISON (Psychology)
KW - AMINO acids
KW - PASTORAL systems
KW - G-type
KW - P-type
KW - Rotavirus
KW - VP4
KW - VP7
N1 - Accession Number: 17855650; Martella, V. 1; Email Address: v.martella@veterinaria.uniba.it Ciarlet, M. 2 Baselga, R. 3 Arista, S. 4 Elia, G. 1 Lorusso, E. 1 Bányai, K. 5 Terio, V. 1 Madio, A. 1 Ruggeri, F.M. 6 Falcone, E. 6 Camero, M. 1 Decaro, N. 1 Buonavoglia, C. 1; Affiliation: 1: Dipartimento di Sanità e Benessere Animale, Facoltà di Medicina Veterinaria di Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy 2: Biologics-Clinical Research, Merck & Co., Inc., Blue Bell, PA, USA 3: Exopol S.L., Zaragoza, Spain 4: Department of Hygiene and Microbiology, University of Palermo, Palermo, Italy 5: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 6: Dipartimento di Sanità alimentare e animale, Istituto Superiore di Sanità, Rome, Italy; Source Info: Jun2005, Vol. 337 Issue 1, p111; Subject Term: ROTAVIRUSES; Subject Term: COMPARISON (Psychology); Subject Term: AMINO acids; Subject Term: PASTORAL systems; Author-Supplied Keyword: G-type; Author-Supplied Keyword: P-type; Author-Supplied Keyword: Rotavirus; Author-Supplied Keyword: VP4; Author-Supplied Keyword: VP7; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.virol.2005.03.031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17855650&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atkins, David
AU - Fink, Kenneth
AU - Slutsky, Jean
T1 - Better Information for Better Health Care: The Evidence-based Practice Center Program and the Agency for Healthcare Research and Quality.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2005/06/22/6/21/2005 Supplement
VL - 142
M3 - Article
SP - 1035
EP - W-245
SN - 00034819
AB - To provide decision makers with the best available evidence, the Agency for Healthcare Research and Quality established a network of Evidence-based Practice Centers across North America. The centers perform systematic reviews on important questions posed by partner organizations about clinical, organizational, and policy interventions in health care. The Agency works closely with partners and other decision makers to help translate that evidence into practice or policy. In this paper, we review important lessons we have learned over the past 7 years about how to increase the efficiency and impact of systematic reviews. Lessons concern selecting the right topics and scope, working effectively with partners, and balancing consistency and flexibility in methods. We examine continuing evolutions of the program and the impact of planned work on comparative effectiveness performed as part of the Medicare Modernization Act of 2003. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- United States
KW - MEDICAL policy
KW - HEALTH insurance
KW - PUBLIC health
KW - SYSTEMATIC reviews (Medical research)
KW - UNITED States
N1 - Accession Number: 17412922; Atkins, David 1; Email Address: datkins@ahrq.gov. Fink, Kenneth Slutsky, Jean; Affiliation: 1: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850.; Source Info: 6/21/2005 Supplement, Vol. 142, p1035; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL policy; Subject Term: HEALTH insurance; Subject Term: PUBLIC health; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: UNITED States; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106522873
T1 - Better information for better health care: the Evidence-Based Practice Center program and the Agency for Healthcare Research and Quality.
AU - Atkins D
AU - Fink K
AU - Slutsky J
Y1 - 2005/06/22/6/21/2005 Supplement
N1 - Accession Number: 106522873. Language: English. Entry Date: 20051007. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Supplement Title: 6/21/2005 Supplement. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Medical Practice, Evidence-Based
KW - United States Agency for Healthcare Research and Quality
KW - Medical Practice, Evidence-Based -- Trends
KW - Program Development
KW - Systematic Review
SP - 1035
EP - 1041
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 142
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - To provide decision makers with the best available evidence, the Agency for Healthcare Research and Quality established a network of Evidence-based Practice Centers across North America. The centers perform systematic reviews on important questions posed by partner organizations about clinical, organizational, and policy interventions in healthcare. The Agency works closely with partners and other decision maker s to help translate that evidence into practice or policy. In this paper, we review important lessons we have learned over the past 7 years about how to increase the efficiency and impact of systematic reviews. Lessons concern selecting the right topics and scope, working effectively with partners, and balancing consistency and flexibility in methods. We examine continuing evolutions of the program and the impact of planned work on comparative effectiveness performed as part of the Medicare Modernization Act of 2003.
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; datkins@ahrq.gov
U2 - PMID: 15968027.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106522902
T1 - Challenges in using nonrandomized studies in systematic reviews of treatment interventions.
AU - Norris SL
AU - Atkins D
Y1 - 2005/06/22/6/21/2005 Supplement
N1 - Accession Number: 106522902. Language: English. Entry Date: 20051007. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Supplement Title: 6/21/2005 Supplement. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Clinical Trials -- Utilization
KW - Medical Practice, Evidence-Based
KW - Study Design
KW - Systematic Review -- Methods
KW - Medical Practice, Evidence-Based -- Methods
KW - Nomenclature
SP - 1112
EP - 1119
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 142
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - Randomized, controlled trials (RCTs) are firmly established as the standard for determining which medical treatments are effective. In some areas of health care, however, among them surgery, public health, and the organization of health care delivery, most evidence addressing the effectiveness of clinical or policy interventions rests on nonrandomized studies. We examine the use of study designs other than RCTs in Evidence-based Practice Center reports addressing questions of the effectiveness of treatment interventions. These reports offer the opportunity to examine the approaches used and the challenges faced by reviewers when nonrandomized studies are included and their quality assessed. We then offer recommendations for using these studies in systematic reviews of treatment interventions.
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Center for Outcomes and Evidence, Room 6325, 540 Gaither Road, Rockville, MD 20850; snorris@ahrq.gov
U2 - PMID: 15968036.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chen, Fei
T1 - Is NF-κB a culprit in type 2 diabetes?
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/06/24/
VL - 332
IS - 1
M3 - Article
SP - 1
EP - 3
SN - 0006291X
AB - Abstract: It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-κB signaling. Earlier studies indicated that IKKβ was the key for the development of insulin resistance. However, it was unknown whether IKKβ itself, or its downstream target, NF-κB, plays major roles in insulin resistance. New data suggest that NF-κB and NF-κB-regulated cytokines are crucial for the diabetogenesis. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES -- Complications
KW - NON-insulin-dependent diabetes
KW - ENDOCRINE diseases
KW - HYPOGLYCEMIC agents
KW - Diabetes
KW - IKKβ
KW - Insulin resistance
KW - NF-κB
N1 - Accession Number: 17827163; Chen, Fei 1; Email Address: fchen@cdc.gov; Affiliation: 1: The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Jun2005, Vol. 332 Issue 1, p1; Subject Term: DIABETES -- Complications; Subject Term: NON-insulin-dependent diabetes; Subject Term: ENDOCRINE diseases; Subject Term: HYPOGLYCEMIC agents; Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: IKKβ; Author-Supplied Keyword: Insulin resistance; Author-Supplied Keyword: NF-κB; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.03.075
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Passerini, Anthony G.
AU - Shi, Congzhu
AU - Francesco, Nadeene M.
AU - Chuan, Peiying
AU - Manduchi, Elisabetta
AU - Grant, Gregory R.
AU - Stoeckert, Christian J.
AU - Karanian, John W.
AU - Wray-Cahen, Diane
AU - Pritchard, William F.
AU - Davies, Peter F.
T1 - Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/06/24/
VL - 332
IS - 1
M3 - Article
SP - 142
EP - 148
SN - 0006291X
AB - Abstract: Regional arterial hemodynamics correlates with distinct endothelial phenotypes that may be modified by risk factors to influence focal and regional susceptibility to atherosclerosis. We compared endothelial transcript profiles from hemodynamically distinct arterial regions in 15 mature pigs: males and females fed a normal diet, and males fed a high-fat diet (15% lard, 1.5% cholesterol) for two weeks. Hierarchical clustering analysis showed preferential grouping of arrays by region over risk factor. A set of differentially expressed genes was identified which clearly distinguished regions of disturbed flow from undisturbed flow; however, few differences were observed within the same region based on gender or diet. Consistent with previous results in the absence of risk factors, the balance in gene expression was not inherently pathological at this early time-point. The results implicate regional hemodynamics as a predominant epigenetic determinant of endothelial phenotypic heterogeneity underlying atherosusceptibility in vivo. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODYNAMICS
KW - GENOTYPE-environment interaction
KW - ISOPENTENOIDS
KW - LOW-cholesterol diet
KW - Atherosclerosis
KW - Cholesterol
KW - Endothelial cell heterogeneity
KW - In vivo
KW - Microarray
KW - Pig
KW - Regional arterial hemodynamics
N1 - Accession Number: 17827183; Passerini, Anthony G. 1,2; Email Address: passerin@mail.med.upenn.edu Shi, Congzhu 1 Francesco, Nadeene M. 1 Chuan, Peiying 1,2 Manduchi, Elisabetta 3 Grant, Gregory R. 3 Stoeckert, Christian J. 3 Karanian, John W. 4 Wray-Cahen, Diane 4 Pritchard, William F. 4 Davies, Peter F. 1,2,5; Email Address: pfd@pobox.upenn.edu; Affiliation: 1: Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA 2: Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA, USA 3: Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA 4: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 5: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Source Info: Jun2005, Vol. 332 Issue 1, p142; Subject Term: HEMODYNAMICS; Subject Term: GENOTYPE-environment interaction; Subject Term: ISOPENTENOIDS; Subject Term: LOW-cholesterol diet; Author-Supplied Keyword: Atherosclerosis; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: Endothelial cell heterogeneity; Author-Supplied Keyword: In vivo; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Pig; Author-Supplied Keyword: Regional arterial hemodynamics; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.04.103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yanping Huang
AU - Norton, Darrell D.
AU - Precht, Patricia
AU - Martindale, Jennifer L.
AU - Burkhardt, Janis K.
AU - Wange, Ronald L.
T1 - Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T CeIIs.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/06/24/
VL - 280
IS - 25
M3 - Article
SP - 23576
EP - 23583
SN - 00219258
AB - ADAP (adhesion and degranulation-promoting adaptor protein) and SKAP55 (Src kinase-associated phosphoprotein of 55 kDa) are T cell adaptors that mediate inside-out signaling from the T cell antigen receptor to integrins, giving rise to increased integrin affinity/avidity and formation of the immunological synapse between the T cell and the antigen-presenting cell. These two proteins are tightly and constitutively associated with one another, and their ability to interact is required for inside-out signaling. Here we show in an ADAP-deficient Jurkat T cell line that the co-dependence of ADAP and SKAP55 extends beyond their functional and physical interactions and show that SKAP55 protein is unstable in the absence of ADAP. Restoration of ADAP to the ADAP-deficient Jurkat T cell line restores SKAP55 expression by causing a 5-fold decrease in the rate of SKAP55 proteolysis. Inactivation of the Src homology 3 domain of SKAP55, which mediates the association between SKAP55 with ADAP, blocks the protective effect of ADAP. The half-life of SKAP55, in the absence of ADAP, is ∼15-20 min, increasing to 90 min in the presence of ADAP. This is a remarkably rapid rate of turnover for a signaling protein and suggests the possibility that stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOPROTEINS
KW - T cells
KW - LYMPHOCYTES
KW - ANTIGENS
KW - INTEGRINS
KW - CELL adhesion molecules
N1 - Accession Number: 17529565; Yanping Huang 1; Email Address: HUANGY@email.chop.edu Norton, Darrell D. 1 Precht, Patricia 1 Martindale, Jennifer L. 1 Burkhardt, Janis K. 2 Wange, Ronald L. 3; Affiliation: 1: Laboratory of Cellular and Molecular Biology, NIA, National Institutes of Health, Intramural Research Program/Department of Health and Human Services, Baltimore, Maryland 21224 2: Department of Pathology, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 3: Center for Drug Evaluation and Research, Food & Drug Administration, 5600 Fishers Ln., HFD-510, Rockville, MD 20857; Source Info: 6/24/2005, Vol. 280 Issue 25, p23576; Subject Term: PHOSPHOPROTEINS; Subject Term: T cells; Subject Term: LYMPHOCYTES; Subject Term: ANTIGENS; Subject Term: INTEGRINS; Subject Term: CELL adhesion molecules; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 6 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1074/jbc.M413201200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neznanov, Niekolay
AU - Chumakov, Konstantin M.
AU - Neznanova, Lubov
AU - Almasan, Alexandru
AU - Banerjee, Amiya K.
AU - Gudkov, Andrei V.
T1 - Proteolytic Cleavage of the p65-ReIA Subunit of NF-κB during Poliovirus Infection.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/06/24/
VL - 280
IS - 25
M3 - Article
SP - 24153
EP - 24158
SN - 00219258
AB - Activation of NF-κB during viral infection is one of the critical elements in innate immune response. Several virus-specific factors, such as double-stranded RNA, can trigger host defense mechanisms by inducing NF-κB-mediated expression of cytokines and interferons. Early stages of poliovirus infection are also associated with degradation of IκBα and translocation of NF-κB into the nucleus. However, at later stages of poliovirus replication the p65-RelA component of the NF-κB complex undergoes a specific cleavage that coincides with the onset of intensive poliovirus protein synthesis and the appearance of the activity of poliovirus protease 3C. Indeed, the p65RelA amino acid sequence contains the recognition site for 3C, and recombinant protein 3C was shown to be capable of proteolytic cleavage of p65-RelA, generating truncated product similar to that observed during poliovirus infection. Cleavage of p65-RelA occurs during replication of ECHO-1 and rhinovirus 14, suggesting that inactivation of NF-κB function by proteolytic cleavage of p65RelA is the common mechanism by which picomaviruses suppress the innate immune response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIOVIRUS
KW - PROTEOLYTIC enzymes
KW - ENTEROVIRUSES
KW - VIRUS diseases
KW - IMMUNE response
KW - IMMUNOLOGY
N1 - Accession Number: 17529632; Neznanov, Niekolay 1; Email Address: neznann@ccf.org Chumakov, Konstantin M. 2 Neznanova, Lubov 1 Almasan, Alexandru 3 Banerjee, Amiya K. 1 Gudkov, Andrei V. 1; Email Address: Gudkov@ccf.org; Affiliation: 1: Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195 2: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Rockuille, Maryland 20852 3: Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195; Source Info: 6/24/2005, Vol. 280 Issue 25, p24153; Subject Term: POLIOVIRUS; Subject Term: PROTEOLYTIC enzymes; Subject Term: ENTEROVIRUSES; Subject Term: VIRUS diseases; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Number of Pages: 6p; Illustrations: 5 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M502303200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowski, Diane K.
AU - Swartz, Lynette
T1 - Adverse Drug Event Surveillance and Drug Withdrawals in the United States, 1969-2002: The Importance of Reporting Suspected Reactions.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2005/06/27/
VL - 165
IS - 12
M3 - Article
SP - 1363
EP - 1369
SN - 00039926
AB - Background The Adverse Event Reporting System is the primary surveillance database used by the Food and Drug Administration for identifying postmarketing drug safety problems. Methods We analyzed all reports of suspected adverse drug reactions submitted to the Food and Drug Administration from the inception of the Adverse Event Reporting System database in 1969 through December 2002. We documented drug withdrawals and restricted distribution programs based on safety concerns. Results During the 33-year period from 1969 when adverse drug event reporting was initiated through 2002, about 2.3 million case reports of adverse events for the cumulative number of approximately 6000 marketed drugs were entered in the database. Most reports were for female patients. During this period, numerous drug reactions have been identified and added to the product labeling as boxed warnings, warnings, precautions, contraindications, and adverse reactions. More than 75 drugs/drug products have been removed from the market due to safety problems. In addition, 11 drugs have special requirements for prescriptions or have restricted distribution programs. Drugs withdrawn or restricted represent a small proportion (about 1%) of marketed drugs. Conclusions The Food and Drug Administration’s Adverse Event Reporting System is the primary surveillance database used for the identification of safety problems of marketed drugs. Despite the limitations of underreporting, differential reporting, and uneven quality, submitted reports often allow the identification of serious adverse events that are added to the product labeling information. In rare instances, additional regulations, up to and including market removal, have been required. We encourage physicians, pharmacists, other health care professionals, and patients to continue to report serious suspected and known adverse drug reactions to manufacturers and the Food and Drug Administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Internal Medicine is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Side effects
KW - ELECTRONIC health records
KW - PUBLIC health surveillance
KW - MEDICINE -- Formulae, receipts, prescriptions
KW - PHARMACOEPIDEMIOLOGY
KW - REPORTING
KW - UNITED States
KW - Adverse
KW - Drug Reaction
KW - Drug Reaction, Adverse
KW - Drug Withdrawal Symptoms see Substance Withdrawal Syndrome
KW - Epidemiologic Studies
KW - Postmarketing
KW - Product Surveillance
KW - Product Surveillance, Postmarketing
KW - Substance Withdrawal Syndrome
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 17457039; Wysowski, Diane K. 1 Swartz, Lynette 1; Affiliation: 1: Office of Drug Safety, Food and Drug Administration, Rockville, Md.; Source Info: 6/27/2005, Vol. 165 Issue 12, p1363; Subject Term: DRUGS -- Side effects; Subject Term: ELECTRONIC health records; Subject Term: PUBLIC health surveillance; Subject Term: MEDICINE -- Formulae, receipts, prescriptions; Subject Term: PHARMACOEPIDEMIOLOGY; Subject Term: REPORTING; Subject Term: UNITED States; Author-Supplied Keyword: Adverse; Author-Supplied Keyword: Drug Reaction; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Drug Withdrawal Symptoms see Substance Withdrawal Syndrome; Author-Supplied Keyword: Epidemiologic Studies; Author-Supplied Keyword: Postmarketing; Author-Supplied Keyword: Product Surveillance; Author-Supplied Keyword: Product Surveillance, Postmarketing; Author-Supplied Keyword: Substance Withdrawal Syndrome; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106240696
T1 - Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions.
AU - Wysowski DK
AU - Swartz L
Y1 - 2005/06/27/
N1 - Accession Number: 106240696. Language: English. Entry Date: 20070223. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Adverse Drug Event
KW - Drugs -- Adverse Effects
KW - United States Food and Drug Administration
KW - Adolescence
KW - Adult
KW - Aged
KW - Child
KW - Demography
KW - Drug Approval -- Administration
KW - Female
KW - Male
KW - Middle Age
KW - United States
KW - Human
SP - 1363
EP - 1369
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 165
IS - 12
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Office of Drug Safety, Food and Drug Administration, Rockville, Md.
U2 - PMID: 15983284.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bird, Aaron J.
T1 - Use of Numerical Calculations to Simulate the Sampling Efficiency Performance of a Personal Aerosol Sampler.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2005/07//
VL - 39
IS - 7
M3 - Article
SP - 596
EP - 610
SN - 02786826
AB - Numerical calculations were conducted to simulate air and particle behavior near and into the inlet of an aerosol sampler in order to determine sampling efficiency performance. This was done with the pre-verified commercial computational fluid dynamics (CFD) software package, FLUENT (Fluent, Inc., Lebanon, NH, US). Air flow behavior was calculated for steady-state conditions approaching and flowing into 3D geometries of an aerosol sampler free in the air that was similar in dimension to two commercial samplers, namely the Gesamtstaubprobenahme sampler (GSP) and the conical inhalable sampler (CIS). Particle trajectories were calculated in a Lagrangian reference frame on the resulting velocity fields. Based on the particle trajectories, sampling efficiencies were calculated and compared to those reported in the literature for a CIS aerosol sampler. They were found to have similar overall trends for particle sizes up to 21 μ m. Using a correction factor, agreement was observed to be very good for smaller particles, but less so for larger particles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLES
KW - AIR flow
KW - SAMPLING (Process)
KW - NUMERICAL calculations
KW - FLUID dynamics
KW - AEROSOLS (Sprays)
N1 - Accession Number: 17718159; Bird, Aaron J. 1; Email Address: ABird@cdc.gov; Affiliation: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Source Info: Jul2005, Vol. 39 Issue 7, p596; Subject Term: PARTICLES; Subject Term: AIR flow; Subject Term: SAMPLING (Process); Subject Term: NUMERICAL calculations; Subject Term: FLUID dynamics; Subject Term: AEROSOLS (Sprays); Number of Pages: 15p; Document Type: Article
L3 - 10.1080/027868291009260
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106516965
T1 - Screening for genital herpes.
AU - Guirguis-Blake J
AU - Wolff TA
Y1 - 2005/07//7/1/2005
N1 - Accession Number: 106516965. Language: English. Entry Date: 20050923. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Health Screening
KW - Herpes Genitalis -- Diagnosis
KW - Herpes Genitalis -- Prevention and Control
KW - Adult
KW - Disease Transmission, Vertical -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Female
KW - Herpes Genitalis -- Transmission
KW - Medical Practice, Evidence-Based
KW - Pregnancy
KW - Prenatal Care
SP - 135
EP - 182
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 72
IS - 1
CY - Skokie, Illinois
PB - American Academy of Family Physicians
T3 - Putting prevention into practice: an evidence-based approach series
SN - 0002-838X
AD - Program Director, US Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality
U2 - PMID: 16035694.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sturgess, Anthony
AU - Macher, Abe
T1 - Issues in Correctional HIV Care: Progressive Disseminated Histoplasmosis.
JO - American Jails
JF - American Jails
Y1 - 2005/07//Jul/Aug2005
VL - 19
IS - 3
M3 - Article
SP - 54
EP - 56
SN - 10560319
AB - Discusses the occurrence of progressive disseminated histoplasmosis in correctional facilities. Description of histoplasmosis as a systemic infection caused by the dimorphic fungus Histoplasma capsulatum; Cutaneous manifestations of disseminated histoplasmosis; Detection of Histoplasma antigen in blood or urine, that is a sensitive method for rapid diagnosis of the condition.
KW - PRISONERS -- Health
KW - HISTOPLASMOSIS
KW - RETICULO-endothelial system -- Infections
KW - SYSTEMIC mycoses
KW - JAILS
KW - CORRECTIONAL institutions
KW - PRISONS
KW - CRIMINAL justice administration
N1 - Accession Number: 17834425; Sturgess, Anthony 1,2 Macher, Abe 3; Affiliation: 1: Health Services Administrator, Montgomery County Department of Correction and Rehabilitation, Boyds, Maryland 2: Chairperson, Correctional Health Care Subcommittee, Metropolitan Washington Council of Governments, Washington, D.C. 3: Chief Medical Advisor, Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, Maryland; Source Info: Jul/Aug2005, Vol. 19 Issue 3, p54; Subject Term: PRISONERS -- Health; Subject Term: HISTOPLASMOSIS; Subject Term: RETICULO-endothelial system -- Infections; Subject Term: SYSTEMIC mycoses; Subject Term: JAILS; Subject Term: CORRECTIONAL institutions; Subject Term: PRISONS; Subject Term: CRIMINAL justice administration; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 913120 Municipal correctional services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106214322
T1 - From the FDA: what's in a label? A guide for the anesthesia practitioner.
AU - Chang NS
AU - Simone AF
AU - Schultheis LW
Y1 - 2005/07//
N1 - Accession Number: 106214322. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article. Commentary: Roizen MF. What's wrong with this label? (ANESTHESIOLOGY) Jul2005; 103 (1): 4-5. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1300217.
KW - Anesthesia
KW - Anesthesiology
KW - Drug Labeling
KW - Government Regulations
KW - Medical Practice
KW - Prescribing Patterns
KW - United States Food and Drug Administration
KW - United States
SP - 179
EP - 185
JO - Anesthesiology
JF - Anesthesiology
JA - ANESTHESIOLOGY
VL - 103
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0003-3022
AD - Food and Drug Administration, Rockville, Maryland 20857, USA.
U2 - PMID: 15983471.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - CURWIN, BRIAN D.
AU - EIN, MISTY J.
AU - SANDERSON, WAYNE T.
AU - NISHIOKA, MARCIA G.
AU - BUHLER, WAYNE
T1 - Nicotine Exposure and Decontamination on Tobacco Harvesters' Hands.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2005/07//
VL - 49
IS - 5
M3 - Article
SP - 407
EP - 413
SN - 00034878
AB - Green tobacco sickness is an illness associated with nicotine exposures among tobacco harvesters. Agricultural workers manually harvest tobacco and thus have the potential for skin exposure to nicotine, particularly on the hands. Often gloves are not worn as it hinders the harvesters' ability to harvest the tobacco leaves. The purposes of this study were to measure the concentration of nicotine residue on the hands of tobacco harvesters and the effectiveness of hand washing at removing the residue. Wipe samples from the hands of 12 tobacco harvesters were collected at the end of morning and afternoon work periods over two consecutive days. Each harvester had one hand wiped before washing his hands, and the other hand wiped after washing his hands with soap and water. Eight samples per worker were collected over the two days for a total of 96 samples collected. In addition to the hand-wipe samples, leaf-wipe samples were collected from 15 tobacco plants to estimate the amount of nicotine residue on the plants. The average nicotine level in leaf-wipe samples was 1.0 μg cm−2. The geometric mean pre-wash and post-wash nicotine levels on the hands were 10 and 0.38 μg cm−2, respectively. Nicotine leaf-wipe level, right or left hand and time of sampling did not significantly influence exposure. Job position—working on the bottom versus the top of the tobacco harvesting machine—was associated with nicotine levels. Pre-wash nicotine levels were higher for workers on the bottom of the harvester but not significantly higher (P = 0.17). Post-wash nicotine levels were significantly higher for workers on the bottom of the harvester (P = 0.012). A substantial amount of nicotine was transferred to the hands, but washing with soap and water in the field significantly reduced nicotine levels by an average of 96% (P < 0.0001). [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Plant-water relationships
KW - Harvesting
KW - Tobacco industry
KW - Smokable plants
KW - Labor laws & legislation
KW - Harvesting machinery
KW - Water -- Religious aspects -- Judaism
KW - Hand -- Care & hygiene
KW - green tobacco sickness
KW - hand exposure
KW - hand washing
KW - nicotine
KW - tobacco harvester
KW - Left Hand, Southern Arapaho chief, ca. 1820-1864?
N1 - Accession Number: 20125676; CURWIN, BRIAN D. 1; EIN, MISTY J. 1; SANDERSON, WAYNE T. 2; NISHIOKA, MARCIA G. 3; BUHLER, WAYNE 4; Affiliations: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MSR-14, Cincinnati, OH 45226, USA;; 2: Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA;; 3: Battelle Memorial Institute, Columbus, OH, USA;; 4: Department of Horticultural Science, North Carolina State University, Raleigh, NC, USA; Issue Info: Jul2005, Vol. 49 Issue 5, p407; Thesaurus Term: Plant-water relationships; Thesaurus Term: Harvesting; Subject Term: Tobacco industry; Subject Term: Smokable plants; Subject Term: Labor laws & legislation; Subject Term: Harvesting machinery; Subject Term: Water -- Religious aspects -- Judaism; Subject Term: Hand -- Care & hygiene; Author-Supplied Keyword: green tobacco sickness; Author-Supplied Keyword: hand exposure; Author-Supplied Keyword: hand washing; Author-Supplied Keyword: nicotine; Author-Supplied Keyword: tobacco harvester; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; People: Left Hand, Southern Arapaho chief, ca. 1820-1864?; Number of Pages: 7p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106446364
T1 - FDA policy on unapproved drug products: past, present, and future.
AU - Chhabra R
AU - Kremzner ME
AU - Kiliany BJ
Y1 - 2005/07//2005 Jul-Aug
N1 - Accession Number: 106446364. Language: English. Entry Date: 20060526. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9203131.
KW - Drug Approval -- Legislation and Jurisprudence
KW - Government Regulations
KW - Health Policy
KW - Safety
KW - United States Food and Drug Administration
KW - United States
SP - 1260
EP - 1264
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
JA - ANN PHARMACOTHER
VL - 39
IS - 7/8
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1060-0280
AD - Team Leader, Division of Drug Information, Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Ln., HFD-240, Rockville, MD 20857-0001; chhabrar@cder.fda.gov
U2 - PMID: 15956239.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sharma, Shashi K.
AU - Eblen, Brian S.
AU - Bull, Robert L.
AU - Burr, Donald H.
AU - Whiting, Richard C.
T1 - Evaluation of Lateral-Flow Clostridium botulinum Neurotoxin Detection Kits for Food Analysis.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2005/07//
VL - 71
IS - 7
M3 - Article
SP - 3935
EP - 3941
SN - 00992240
AB - The suitability and sensitivity of two in vitro lateral-flow assays for detecting Clostridium botulinum neurotoxins (BoNTs) in an assortment of foods were evaluated. Toxin extraction and preparation methods for various liquid, solid, and high-fat-content foods were developed. The lateral-flow assays, one developed by the Naval Medical Research Center (Silver Spring, MD) and the other by Alexeter Technologies (Gaithersburg, MD), are based on the immunodetection of BoNT types A, B, and E. The assays were found to be rapid and easy to perform with minimum requirements for laboratory equipment or skills. They can readily detect 10 ng/ml of BoNT types A and B and 20 ng/ml of BoNT type E. Compared to other in vitro detection methods, these assays are less sensitive, and the assessment of a result is strictly qualitative. However, the assay was found to be simple to use and to require minimal training. The assays successfully detected BoNT types A, B, and E in a wide variety of foods, suggesting their potential usefulness as a preliminary screening system for triaging food samples with elevated BoNT levels in the event of a C. botulinum contamination event. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM botulinum
KW - FOOD -- Analysis
KW - BOTULINUM toxin
KW - NEUROTOXIC agents
KW - MEDICAL research
KW - MICROBIOLOGY
N1 - Accession Number: 17745539; Sharma, Shashi K. 1; Email Address: Shashi.Sharma@jcfsan.fda.gov Eblen, Brian S. 1 Bull, Robert L. 2 Burr, Donald H. 3 Whiting, Richard C. 1; Affiliation: 1: U. S. Food and Drug Administration, Center for Food Safely and Applied Nutrition, College Park, Maryland 20740. 2: Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring Maryland 209102. 3: National Center for Food Safety and Technology, Summit-Argo, Illinois 605010; Source Info: Jul2005, Vol. 71 Issue 7, p3935; Subject Term: CLOSTRIDIUM botulinum; Subject Term: FOOD -- Analysis; Subject Term: BOTULINUM toxin; Subject Term: NEUROTOXIC agents; Subject Term: MEDICAL research; Subject Term: MICROBIOLOGY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1128/AEM.71.7.3935-3941.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Albers, Jim
AU - Estill, Cherie
AU - MacDonald, Leslie
T1 - Identification of ergonomics interventions used to reduce musculoskeletal loading for building installation tasks
JO - Applied Ergonomics
JF - Applied Ergonomics
Y1 - 2005/07//
VL - 36
IS - 4
M3 - Article
SP - 427
EP - 439
SN - 00036870
AB - Abstract: Skilled workers in the mechanical and electrical installation (M/EI) building and construction trades experience high rates of disabling work-related musculoskeletal disorders (WMSDs). The M/EI trades involve installing piping; heating, ventilation and air conditioning (HVAC), and electrical systems in residential, commercial, and industrial buildings. In the absence of an ergonomics standard in the United States, some building and construction contractors, including M/EI sector contractors, have implemented various ergonomics interventions on their worksites on a voluntary basis. However, no data were available to determine the type of voluntary control measures being implemented, the task-specific hazards for which control measures needed to be developed or refined, and perceived barriers to improving hazard control. As part of a larger effort to obtain this data, the National Institute for Occupational Safety and Health (NIOSH) organized a stakeholder meeting to gather information regarding ergonomics interventions or ‘best practices’ by M/EI contractors and tradespeople. The attendees included 39 industry representatives, 17 construction ergonomics researchers from government and academia, and four ergonomics consultants with experience in the construction industry. Participants spent more than 50% of time meeting in small trade-specific breakout sessions. According to the participants, tasks common to the three trades included (1) drill holes and shoot fasteners; (2) place and install systems, and (3) lift and carry materials and equipment. Engineering interventions described in the stakeholder meeting included tools, equipment, and engineered building materials; administrative controls largely consisted of training and education programs and modifications of work and management practice. Most participants believed that there were significant limits to the impact individual contractors and tradespeople could have in leading ergonomics improvement in the building and construction industry. [Copyright &y& Elsevier]
AB - Copyright of Applied Ergonomics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL engineering
KW - VENTILATION
KW - CONSTRUCTION industry
KW - AIR conditioning
KW - Construction industry
KW - Ergonomics intervention
KW - Work-related musculoskeletal disorder
N1 - Accession Number: 17812124; Albers, Jim; Email Address: jalbers@cdc.gov Estill, Cherie 1 MacDonald, Leslie 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226, USA; Source Info: Jul2005, Vol. 36 Issue 4, p427; Subject Term: INDUSTRIAL engineering; Subject Term: VENTILATION; Subject Term: CONSTRUCTION industry; Subject Term: AIR conditioning; Author-Supplied Keyword: Construction industry; Author-Supplied Keyword: Ergonomics intervention; Author-Supplied Keyword: Work-related musculoskeletal disorder; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 236110 Residential building construction; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.apergo.2004.07.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manderscheid, Ronald W.
T1 - REBOOTING BEHAVIORAL HEALTHCARE.
JO - Behavioral Health Management
JF - Behavioral Health Management
Y1 - 2005/07//Jul/Aug2005
VL - 25
IS - 4
M3 - Article
SP - 50
EP - 52
PB - Vendome Group LLC
SN - 10756701
AB - Comments on the transformation of the mental health system in the U.S. Strategies essential to the transformation process, including the implementation of appropriate performance measures; Association of the transformation process with state-of-the-art information technology (IT); Development of a strategic plan for the implementation of an IT infrastructure in the behavioral healthcare field; Creation of a Center for Technology Innovation in Behavioral Healthcare to address the need for rapid application of IT to service delivery and to information processing.
KW - MENTAL health services
KW - MENTAL health
KW - PERFORMANCE standards
KW - INFORMATION technology
KW - TECHNOLOGICAL innovations
KW - UNITED States
N1 - Accession Number: 18096479; Manderscheid, Ronald W. 1; Email Address: manderscheid0705@behavioral.net; Affiliation: 1: Chief, Survey & Analysis, SAMHSA's Center for Mental Health Services; Source Info: Jul/Aug2005, Vol. 25 Issue 4, p50; Subject Term: MENTAL health services; Subject Term: MENTAL health; Subject Term: PERFORMANCE standards; Subject Term: INFORMATION technology; Subject Term: TECHNOLOGICAL innovations; Subject Term: UNITED States; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106328043
T1 - What the code of federal regulations means to you.
AU - Yellin A
AU - Yellin, Arthur
Y1 - 2005/07//Jul/Aug2005
N1 - Accession Number: 106328043. Language: English. Entry Date: 20060901. Revision Date: 20161117. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Government Regulations
KW - United States Food and Drug Administration -- Legislation and Jurisprudence
KW - Equipment and Supplies -- Standards
KW - Biomedical Engineering
SP - 285
EP - 287
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 39
IS - 4
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
SN - 0899-8205
AD - Division of Small Manufacturers, International and Consumer Assistance, Center for Devices and Radiological Health, Food and Drug Administration, USA
AD - Regulatory Policy Analyst, Division of Small Manufacturers, International and Consumer Assistance, Center for Devices and Radiological Health, Food and Drug Administration
U2 - PMID: 16111404.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106328058
T1 - The critical path to new medical devices.
AU - Ashar B
AU - Barnett M
AU - Schultz D
AU - Ashar, Binita
AU - Barnett, Mark
AU - Schultz, Daniel
Y1 - 2005/07//Jul/Aug2005
N1 - Accession Number: 106328058. Language: English. Entry Date: 20060901. Revision Date: 20161117. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Equipment and Supplies
KW - Device Approval
KW - Government Programs
KW - United States Food and Drug Administration
SP - 304
EP - 306
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 39
IS - 4
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
SN - 0899-8205
AD - FDA Center for Devices and Radiological Health, USA
AD - Acting Clinical Deputy Director, FDA Center for Devices and Radiological Health (CDRH)
U2 - PMID: 16111410.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brailer, David J.
AD - US Department of Health and Human Services
T1 - Economic Perspectives on Health Information Technology
JO - Business Economics
JF - Business Economics
Y1 - 2005/07//
VL - 40
IS - 3
SP - 6
EP - 14
SN - 0007666X
N1 - Accession Number: 0811695; Keywords: Health Care; Health; Technology; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200601
N2 - It seems paradoxical that health care spending and examples of inferior health care have been rising rapidly at the same time. An important factor is the slow pace at which the health care system has adopted information technology (IT). This paper discusses the dimensions of the problems that could be mitigated by effective use of IT in the health care system, their consequences, and their potential solutions. It also discusses the economic and institutional barriers to deploying IT and how the inherent economies of scale in IT are likely to lead to new problems of competition within the health care system. Inasmuch as this paper was based on an address followed by a question-and-answer period, it also includes an edited version of the recorded questions and answers.
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Information and Internet Services; Computer Software L86
KW - Technological Change: Choices and Consequences; Diffusion Processes O33
L3 - http://www.palgrave-journals.com/be/archive/index.html
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Ximenes, Eduardo A.
AU - Huizhong Chen
AU - Kataeva, Irina A.
AU - Cotta, Michael A.
AU - Felix, Carlos R.
AU - Ljungdahl, Lars G.
AU - Xin-Liang Li
T1 - A mannanase, ManA, of the polycentric anaerobic fungus Orpinomyces sp. strain PC-2 has carbohydrate binding and docking modules.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2005/07//
VL - 51
IS - 7
M3 - Article
SP - 559
EP - 568
PB - Canadian Science Publishing
SN - 00084166
AB - The anaerobic fungus Orpinomyces sp. strain PC-2 produces a broad spectrum of glycoside hydrolases, most of which are components of a high molecular mass cellulosomal complex. Here we report about a cDNA (manA) having 1924 bp isolated from the fungus and found to encode a polypeptide of 579 amino acid residues. Analysis of the deduced sequence revealed that it had a mannanase catalytic module, a family 1 carbohydrate-binding module, and a noncatalytic docking module. The catalytic module was homologous to aerobic fungal mannanases belonging to family 5 glycoside hydrolases, but unrelated to the previously isolated mannanases (family 26) of the anaerobic fungus Piromyces. No mannanase activity could be detected in Escherichia coli harboring a manA-containing plasmid. The manA was expressed in Saccharomyces cerevisiae and ManA was secreted into the culture medium in multiple forms. The purified extracellular heterologous mannanase hydrolyzed several types of mannan but lacked activity against cellulose, chitin, or β-glucan. The enzyme had high specific activity toward locust bean mannan and an extremely broad pH profile. It was stable for several hours at 50 °C, but was rapidly inactivated at 60 °C. The carbohydrate-binding module of the Man A produced separately in E. coli bound preferably to insoluble lignocellulosic substrates, suggesting that it might play an important role in the complex enzyme system of the fungus for lignocellulose degradation. (English) [ABSTRACT FROM AUTHOR]
AB - Le champignon anaérobie Orpinomyces sp. souche PC-2 produit un large spectre d'hydrolases glycosidiques, la plupart faisant partie d'un complexe cellulosomal de masse moléculaire élevée. Nous faisons ici la description d'un ADNc (manA) de 1924 pb isolé du champignon et codant un polypeptide de 579 acides aminés. L'analyse de la séquence déduite a révélé qu'il renfermait un module catalytique de mannanase, un module de liaison aux glucides de la famille 1 et un module d'arrimage non catalytique. Le module catalytique était homologue à des mannanases de champignons aérobies appartenant aux hydrolases glycosidiques que la famille 5 mais n'était pas apparenté à des mannanases isolées précédemment (famille 26) du champignon anaérobie Piromyces. Aucune activité mannanases n'a pu être détectée chez Escherichia coli renfermant un plasmide contenant manA. Le manA fut exprimé chez Saccharomyces cerevisiae et ManA fut sécrété dans le milieu culture sous des formes multiples. La mannanase hétérologue extracellulaire purifiée a hydrolysé plusieurs types de mannane mais n'a démontré aucune activité envers le cellulose, la chitine ou le β-glucane. L'enzyme a démontré une activité spécifique élevée envers le mannane de caroube et un profil de pH extrêmement large. Elle était stable pendant plusieurs heures à 50 °C mais fut rapidement inactivée à 60 °C. Le module de liaison aux glucides de la mannanase A produite séparément chez E. coli s'est lié de préférence à des substrats lignocellulosiques insolubles, indiquant qu'il pourrait jouer un rôle important dans la dégradation du lignocellulose par le système enzymatique complexe du champignon.[Traduit par la Rédaction] (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANAEROBIC bacteria
KW - GLYCOSIDASES
KW - ANTISENSE DNA
KW - PEPTIDE hormones
KW - AMINO acids
KW - MICROBIOLOGY
KW - anaerobic fungi
KW - cellulose-binding module
KW - cellulosome
KW - mannanase
KW - Orpinomyces
KW - champignons anaérobies
KW - module de liaison au cellulose
N1 - Accession Number: 18589740; Ximenes, Eduardo A. 1 Huizhong Chen 2 Kataeva, Irina A. 3 Cotta, Michael A. 4 Felix, Carlos R. 1 Ljungdahl, Lars G. 3 Xin-Liang Li 4; Email Address: lix@ncaur.usda.gov; Affiliation: 1: Laboratorio De Enzimologia, Departmento De Biologia Celular, Universidade De Brasilia, Asa Norte, Brasilia-DF-Brazil 70910-900, Brazil 2: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA 3: Department of Biochemistry and Molecular Biology and Center for Biological Resource Recovery, The University of Georgia, Athens, GA 30602-7229, USA 4: Fermentation Biotechnology Research Unit, National Center for Agricultural Utilization Research, USDA²/ARS, 1815 N. University Street, Peoria, IL 61604, USA; Source Info: Jul2005, Vol. 51 Issue 7, p559; Subject Term: ANAEROBIC bacteria; Subject Term: GLYCOSIDASES; Subject Term: ANTISENSE DNA; Subject Term: PEPTIDE hormones; Subject Term: AMINO acids; Subject Term: MICROBIOLOGY; Author-Supplied Keyword: anaerobic fungi; Author-Supplied Keyword: cellulose-binding module; Author-Supplied Keyword: cellulosome; Author-Supplied Keyword: mannanase; Author-Supplied Keyword: Orpinomyces; Author-Supplied Keyword: champignons anaérobies; Author-Supplied Keyword: module de liaison au cellulose; Language of Keywords: English; Language of Keywords: French; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1139/W05-033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mehendale, Sangeeta
AU - Han Aung
AU - Anbao Wang
AU - Jun-Jie Yin
AU - Chong-Zhi Wang
AU - Jing-Tian Xie
AU - Chun-Su Yuan
T1 - American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats.
JO - Cancer Chemotherapy & Pharmacology
JF - Cancer Chemotherapy & Pharmacology
Y1 - 2005/07//
VL - 56
IS - 1
M3 - Article
SP - 63
EP - 69
SN - 03445704
AB - Purpose: Cisplatin, a chemotherapeutic agent, causes significant nausea and vomiting. It is postulated that cisplatin-induced oxidant stress may be responsible for these symptoms. We tested whether pretreatment with American ginseng berry extract (AGBE), an herb with potent antioxidant capacity, and one of its active antioxidant constituents, ginsenoside Re, could counter cisplatin-induced emesis using a rat pica model. Methods: In rats, exposure to emetic stimuli such as cisplatin causes significant kaolin intake, a phenomenon called pica. We therefore measured cisplatin-induced kaolin intake as an indicator of the emetic response. Rats were pretreated with vehicle, AGBE (dose range 50-150 mg/kg, IP) or ginsenoside Re (2 and 5 mg/kg, IP). Rats were treated with cisplatin (3 mg/kg, IP) 30 min later. Kaolin intake, food intake, and body weight were measured every 24 h for 120 h. Additionally, the free radical scavenging activity of AGBE was measured in vitro using ESR spectroscopy. Results: A significant dose-response relationship was observed between increasing doses of pretreatment with AGBE and reduction in cisplatin-induced pica. Kaolin intake was maximally attenuated by AGBE at a dose of 100 mg/kg. Food intake also improved significantly at this dose (P<0.05). Pretreatment with ginsenoside Re (5 mg/kg) also decreased kaolin intake (P<0.05). In vitro studies demonstrated a concentration-response relationship between AGBE and its ability to scavenge superoxide and hydroxyl radicals. Conclusion: Pretreatment with AGBE and its major constituent, Re, attenuated cisplatin-induced pica, and demonstrated potential for the treatment of chemotherapy-induced nausea and vomiting. Significant recovery of food intake further strengthens the conclusion that AGBE may exert an antinausea/antiemetic effect. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMERICAN ginseng
KW - CISPLATIN
KW - KAOLIN
KW - ANTIOXIDANTS
KW - ANTINEOPLASTIC agents
KW - ALKYLATING agents
KW - American ginseng
KW - Berry
KW - Cisplatin
KW - Ginsenoside Re
KW - Herbal medicine
N1 - Accession Number: 16947928; Mehendale, Sangeeta 1,2 Han Aung 1,2 Anbao Wang 1,2 Jun-Jie Yin 3 Chong-Zhi Wang 1,2 Jing-Tian Xie 1,2 Chun-Su Yuan 1,2,4; Email Address: cyuan@airway.uchicago.edu; Affiliation: 1: Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, IL, USA 2: Departments of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, Chicago, IL, USA 3: Center for Food Safety and Applied Nutrition, FDA, MD, USA 4: Committee on Clinical Pharmacology and Pharmacogenomics, The Pritzker School of Medicine, University of Chicago, Chicago, IL, USA; Source Info: Jul2005, Vol. 56 Issue 1, p63; Subject Term: AMERICAN ginseng; Subject Term: CISPLATIN; Subject Term: KAOLIN; Subject Term: ANTIOXIDANTS; Subject Term: ANTINEOPLASTIC agents; Subject Term: ALKYLATING agents; Author-Supplied Keyword: American ginseng; Author-Supplied Keyword: Berry; Author-Supplied Keyword: Cisplatin; Author-Supplied Keyword: Ginsenoside Re; Author-Supplied Keyword: Herbal medicine; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 212324 Kaolin and Ball Clay Mining; NAICS/Industry Codes: 212326 Shale, clay and refractory mineral mining and quarrying; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s00280-004-0956-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malejka-Giganti, Danuta
AU - Bennett, Kristen K.
AU - Culp, Sandra J.
AU - Beland, Frederick A.
AU - Shinozuka, Hisashi
AU - Bliss, Robin L.
T1 - Suppression of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis by pre-initiation treatment of rats with β-naphthoflavone coincides with decreased levels of the carcinogen-derived DNA adducts in the mammary gland
JO - Cancer Detection & Prevention
JF - Cancer Detection & Prevention
Y1 - 2005/07//
VL - 29
IS - 4
M3 - Article
SP - 338
EP - 347
SN - 0361090X
AB - Abstract: Background: Mechanisms underlying prevention by β-naphthoflavone (β-NF) of mammary carcinogenesis initiated with 7,12-dimethylbenz[a]anthracene (DMBA) in the rat were elucidated. Methods and results: Treatment of female Sprague–Dawley rats with β-NF at 40mg/kg b.wt. for 4 days by oral gavage in corn oil before a single oral dose of DMBA (112mg/kg b.wt.) suppressed mammary gland carcinogenesis as shown by an increase in the median latent period from 10 to 24 weeks and a 60% decrease in the multiplicity of mammary adenocarcinomas. In contrast, a 20-day treatment with β-NF starting 3 weeks after DMBA had no significant effects on mammary tumorigenesis. The activities of phase I and phase II enzymes were examined in the liver and mammary gland 24h after treatment of rats with β-NF, DMBA, or β-NF followed by DMBA as in the first bioassay. Treatment with either β-NF or DMBA increased the hepatic activities of cytochrome P450 (CYP)1A1, 1A2, and 2B1/2, and glutathione S-transferase, and the mammary activity of CYP1A1. The activity of mammary CYP2B1/2 induced by DMBA was decreased by β-NF. In the liver, the increase of UDP-glucuronosyl transferase (GT) activity in rats treated with β-NF and DMBA was 2.3-fold greater than in rats treated with DMBA alone. Thus, treatment with β-NF likely increased the rate of glucuronidation of DMBA dihydrodiols leading to carcinogen detoxification. The levels of the DMBA adducts determined by 32P-postlabeling of the mammary gland DNA were decreased in the β-NF-pretreated rats. Conclusion: The β-NF-induced increase in the hepatic UDP-GT activity and decrease in the mammary DNA-DMBA adducts occurred under the same treatment regimen that led to suppression of DMBA-induced mammary carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Cancer Detection & Prevention is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - ANTHRACENE
KW - RATS as laboratory animals
KW - ADENOCARCINOMA
KW - BIOLOGICAL assay
KW - MAMMARY glands
KW - β-Naphthoflavone
KW - 7,12-Dimethylbenz[a]anthracene
KW - Enzyme activity determination
KW - Mammary DNA adducts in vivo
KW - Mammary gland carcinogenesis
KW - Nifedipine oxidation (NIFOX)
KW - Phase I/phase II enzymes
KW - Suppression
N1 - Accession Number: 18319378; Malejka-Giganti, Danuta 1,2; Email Address: malej001@umn.edu Bennett, Kristen K. 1 Culp, Sandra J. 3 Beland, Frederick A. 3 Shinozuka, Hisashi 4 Bliss, Robin L. 5; Affiliation: 1: Veterans Affairs Medical Center, Minneapolis, MN 55417, USA 2: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 4: Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA 5: Biostatistics Core, University of Minnesota Comprehensive Cancer Center, Minneapolis, MN 55455, USA; Source Info: Jul2005, Vol. 29 Issue 4, p338; Subject Term: BREAST cancer; Subject Term: ANTHRACENE; Subject Term: RATS as laboratory animals; Subject Term: ADENOCARCINOMA; Subject Term: BIOLOGICAL assay; Subject Term: MAMMARY glands; Author-Supplied Keyword: β-Naphthoflavone; Author-Supplied Keyword: 7,12-Dimethylbenz[a]anthracene; Author-Supplied Keyword: Enzyme activity determination; Author-Supplied Keyword: Mammary DNA adducts in vivo; Author-Supplied Keyword: Mammary gland carcinogenesis; Author-Supplied Keyword: Nifedipine oxidation (NIFOX); Author-Supplied Keyword: Phase I/phase II enzymes; Author-Supplied Keyword: Suppression; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.cdp.2005.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hallman, Mats
AU - Mordenfeld, Arne
AU - Strandkvist, Tomas
T1 - A Retrospective 5-Year Follow-Up Study of Two Different Titanium Implant Surfaces Used after Interpositional Bone Grafting for Reconstruction of the Atrophic Edentulous Maxilla.
JO - Clinical Implant Dentistry & Related Research
JF - Clinical Implant Dentistry & Related Research
Y1 - 2005/07//
VL - 7
IS - 3
M3 - Article
SP - 121
EP - 126
SN - 15230899
AB - Background: Long-term comparative follow-up studies of dental implants placed in augmented bone are rare. Variations in design and surface roughness have been found to be important for bone integration of implants. However, there is no clinical evidence that such variations lead to an improved clinical outcome. Purpose: To compare two different implant systems used after interpositional bone grafting of the severely resorbed maxilla with a modified augmentation technique using fibrin glue. Materials and Methods: Twenty-two consecutive patients presenting with severe maxillary atrophy underwent reconstruction with Le Fort I osteotomies and interpositional bone grafting. Before placement of bone blocks, the floors of the maxillary sinuses were packed with bone chips mixed with a fibrin glue, to stabilize the graft. After 6 months of graft healing, the first 11 consecutive patients received Brånemark System® implants with a turned surface (Nobel Biocare AB, Göteborg, Sweden). The following 11 consecutive patients were treated with Astra Tech implants with a blasted titanium surface (Astra Tech AB, Mölndal, Sweden). All patients received fixed prostheses. Marginal bone resorption and donor and recipient site morbidity were evaluated. All patients were clinically and radiographically observed throughout 5 years of functional loading. Results: In the Brånemark group, 11 (13%) of 84 placed implants were lost, compared to 4 (5.5%) of 72 placed implants in the Astra Tech group. The difference was not significant. All patients retained fixed constructions after 5 years of loading. The mean marginal bone loss was 2.3 F 0.8 mm (range, 0-5.0 mm) in the Brånemark group and 2.4 F 1.4 mm (range, 0-7.0 mm) in the Astra Tech group, although again no statistical difference was found. A larger number of implants in the Astra Tech group had a marginal bone resorption of ≥ 3 mm, and implant success in that group was lower than in the Brånemark group (52% vs 70%). Conclusion: In this study, reconstruction of the severely resorbed maxilla with Le Fort I osteotomy, interpositional bone grafting, and delayed placement of dental implants was found to be a predictable long-term procedure. Although more implants with a turned surface were lost during the follow-up period, there were no statistically significant differences between turned and titanium blasted implants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Implant Dentistry & Related Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL implants
KW - ORAL surgery
KW - ARTIFICIAL implants
KW - FIBRIN tissue adhesive
KW - ADHESIVES in surgery
KW - comparative study
KW - dental implant surface
KW - fibrin glue
KW - interpositional bone grafting
KW - Le Fort I osteotomy
N1 - Accession Number: 18789140; Hallman, Mats 1; Email Address: mats.hallman@lg.se Mordenfeld, Arne 1 Strandkvist, Tomas 1; Affiliation: 1: Department of Oral and Maxillofacial Surgery, Public Health Service, Gävle City, Sweden; Centre for Research and Development, Uppsala University, County Council of Gävleborg, Gävle, Sweden; Source Info: 2005, Vol. 7 Issue 3, p121; Subject Term: DENTAL implants; Subject Term: ORAL surgery; Subject Term: ARTIFICIAL implants; Subject Term: FIBRIN tissue adhesive; Subject Term: ADHESIVES in surgery; Author-Supplied Keyword: comparative study; Author-Supplied Keyword: dental implant surface; Author-Supplied Keyword: fibrin glue; Author-Supplied Keyword: interpositional bone grafting; Author-Supplied Keyword: Le Fort I osteotomy; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106531241
T1 - Topical antiseptics in healthcare.
AU - Jackson MM
Y1 - 2005///Summer2005
N1 - Accession Number: 106531241. Language: English. Entry Date: 20051028. Revision Date: 20150820. Publication Type: Journal Article; CEU; exam questions; glossary; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8806547.
KW - Disinfectants
KW - Disinfectants -- Classification
KW - United States Food and Drug Administration
KW - Government Regulations
KW - Iodine
KW - Chlorhexidine
KW - Education, Continuing (Credit)
SP - 160
EP - 191
JO - Clinical Laboratory Science
JF - Clinical Laboratory Science
JA - CLIN LAB SCI
VL - 18
IS - 3
CY - Tysons Corner, Virginia
PB - American Society for Clinical Laboratory Science
AB - Topical antiseptics are essential for infection control. Antiseptic formulations employ a variety of mechanisms, act at various rates and persistence intervals, demonstrate various levels of toxicity, and are more or less likely to trigger resistance. The desired characteristics are considered when selecting antiseptics for hand washing, surgical scrubbing, and patient preoperative skin preparation. The selection process requires evidence of product safety and efficacy. This article explores currently available topical antimicrobial agents used in medical settings.
SN - 0894-959X
AD - Food and Drug Administration (FDA), Center for Drug Evaluation and Research, Office of Nonprescription Products, 5600 Fishers Lane, HFD-560, Rockville MD 20857; jacksonm@cder.fda.gov
U2 - PMID: 16134476.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Svabek, Scott
T1 - PRE-LIBERATION IRAQI PROCUREMENT PROCESSES: PART 1 OF 2.
JO - Contract Management
JF - Contract Management
Y1 - 2005/07//
VL - 45
IS - 7
M3 - Article
SP - 44
EP - 47
SN - 01903063
AB - Provides insights on the Iraqi health care procurement system. Understanding of how Iraq procured medical items while under the control of the regime of Saddam Hussein; Challenges facing the procurement process; Development of a coalition attempted to move the medical procurement processes.
KW - INDUSTRIAL procurement
KW - MEDICAL care
KW - PLANNING
KW - RISK assessment
KW - RISK management in business
KW - IRAQ
N1 - Accession Number: 17669062; Svabek, Scott 1; Affiliations: 1: Executive Officer, HQDA Office of the Surgeon General in Falls Church, VA; Member of NCMA Battlefield-Dulles Chapter; Issue Info: Jul2005, Vol. 45 Issue 7, p44; Thesaurus Term: INDUSTRIAL procurement; Thesaurus Term: MEDICAL care; Thesaurus Term: PLANNING; Thesaurus Term: RISK assessment; Thesaurus Term: RISK management in business; Subject: IRAQ; Number of Pages: 5p; Illustrations: 1 Color Photograph; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Chi-Jen Lee
AU - Lucia Lee
AU - Xin-Xing Gu
T1 - Mucosal Immunity Induced by Pneumococcal Glycoconjugate.
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
Y1 - 2005/07//Jul-Sep2005
VL - 31
IS - 3
M3 - Article
SP - 137
EP - 144
PB - Taylor & Francis Ltd
SN - 1040841X
AB - Host defenses against Streptococcus pneumoniae involve opsonophagocytosis mediated by antibodies and complement. Because the pneumococcus is a respiratory pathogen, mucosal immunity may play an important role in the defense against infection. The mechanism for protection in mucosal immunity consists of induction of immunity by the activation of lymphocytes within the mucosal-associated lymphoid tissues, transport of antigen-specific B and T cells from inductive sites through bloodstream and distribute to distant mucosal effector sites. Secretory IgA is primarily involved in protection of mucosal surfaces. Mucosal immunization is an effective way of inducing immune responses at mucosal surfaces. Several mucosal vaccines are in various stages of development. A number of mucosal adjuvants have been proposed. CpG oligodeoxynucleotide (ODN) has been shown to be an effective mucosal adjuvant for various antigens. Mucosal immunity induced by intranasal immunization was studied with a pneumococcal glycoconjugate, using CpG ODN as adjuvant. Mice immunized with type 9V polysaccharide (PS) conjugated to inactivated pneumolysin (Ply) plus CpG produced high levels of 9V PS IgG and IgA antibodies compared to the group that received the conjugate alone. High levels of subclasses of IgG1, IgG2 and IgG3 antibodies were also observed in sera of mice immunized with 9V PS-Ply plus CpG. In addition, high IgG and IgA antibody responses were observed in sera of young mice immunized with 9V PS-Ply plus CpG or the conjugate plus non-CpG compared with the group received the conjugate alone. These results reveal that mucosal immunization with pneumococcal glycoconjugate using CpG as adjuvant can confer protective immunity against pneumococcal infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Microbiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cellular immunity
KW - Immune response -- Regulation
KW - Glycoconjugates
KW - Streptococcus pneumoniae
KW - Mucous membrane
KW - Immunoglobulins
KW - CpG Adjuvant
KW - Mucosal Immunity
KW - Mucosal Immunity/Pneumococcal Glycoconjugate/CpG Adjuvant
KW - Pneumococcal Glycoconjugate
N1 - Accession Number: 17843112; Chi-Jen Lee 1; Email Address: leechi@cber.fda.gov; Lucia Lee 1; Xin-Xing Gu 2; Affiliations: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.; 2: National Institute for Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, USA.; Issue Info: Jul-Sep2005, Vol. 31 Issue 3, p137; Thesaurus Term: Cellular immunity; Subject Term: Immune response -- Regulation; Subject Term: Glycoconjugates; Subject Term: Streptococcus pneumoniae; Subject Term: Mucous membrane; Subject Term: Immunoglobulins; Author-Supplied Keyword: CpG Adjuvant; Author-Supplied Keyword: Mucosal Immunity; Author-Supplied Keyword: Mucosal Immunity/Pneumococcal Glycoconjugate/CpG Adjuvant; Author-Supplied Keyword: Pneumococcal Glycoconjugate; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/10408410591005093
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Hai Kwang
AU - Myoungho-Lee
AU - Roh, Hye Won
AU - Lee, Nari
AU - Cho, Yang Ha
AU - Jeong, Jin Baek
AU - Jung, Ho Nyun
AU - Yang, Won Sun
AU - Ryu, Gyu Ha
T1 - DNA chip evaluation as a diagnostic device
JO - Current Applied Physics
JF - Current Applied Physics
Y1 - 2005/07//
VL - 5
IS - 5
M3 - Article
SP - 433
EP - 437
SN - 15671739
AB - Abstract: To use DNA chip as a diagnostic device, it should be evaluated and approved as a medical device. In this study, we developed a guideline for DNA chip evaluation and evaluated a commercialized DNA chip according to the guideline. This guideline consists of three parts: evaluation of quality control system, analytical performance, and clinical performance of DNA chips. First, the quality control system should be evaluated in the aspect of material, manufacturing process, and final product. In addition, the validation of expiration date, storing condition, and required reagents is needed to confirm the quality control system. Second, the analytical performance of DNA chip should be evaluated by accuracy, sensitivity, reproducibility, and cut-off value. Third, the clinical performance of DNA chip should be evaluated by clinical specificity, clinical sensitivity, positive and negative predictive value. We evaluated the accuracy and lot-to-lot reproducibility of a commercial HPV detection DNA chip. We analyzed 20 clinical samples. The accuracy of a DNA chip was evaluated by comparing the test results to DNA sequencing results. Lot-to-lot reproducibility was assessed by consistency of results from three different lots. The accuracy and reproducibility of the HPV DNA chip were almost 100%. In addition to the accuracy and reproducibility, the cut-off value of DNA chip was above 2.3 [Signal to Noise Ratio (SNR)⩾2.3]. [Copyright &y& Elsevier]
AB - Copyright of Current Applied Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - NUCLEIC acids
KW - MEDICAL equipment
KW - QUALITY of products
KW - DNA chip
KW - Evaluation
KW - Guideline
KW - Medical device
KW - Nanotechnology
KW - Performance
N1 - Accession Number: 17952758; Lee, Hai Kwang 1 Myoungho-Lee 2 Roh, Hye Won 1 Lee, Nari 1 Cho, Yang Ha 1 Jeong, Jin Baek 1 Jung, Ho Nyun 1 Yang, Won Sun 1 Ryu, Gyu Ha 1; Email Address: gyuha@kfda.go.kr; Affiliation: 1: Department of Medical Devices and Radiation Health, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Republic of Korea 2: Department of Electrical and Electronics Engineering, Yonsei University, 134 Sinchon-Dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea; Source Info: Jul2005, Vol. 5 Issue 5, p433; Subject Term: DNA; Subject Term: NUCLEIC acids; Subject Term: MEDICAL equipment; Subject Term: QUALITY of products; Author-Supplied Keyword: DNA chip; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Guideline; Author-Supplied Keyword: Medical device; Author-Supplied Keyword: Nanotechnology; Author-Supplied Keyword: Performance; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.cap.2005.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Batz, Michael B.
AU - Doyle, Michael P.
AU - Morris Jr., J. Glenn
AU - Painter, John
AU - Singh, Ruby
AU - Tauxe, Robert V.
AU - Taylor, Michael R.
AU - Lo Fo Wong, Danilo M. A.
T1 - Attributing Illness to Food.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2005/07//
VL - 11
IS - 7
M3 - Article
SP - 993
EP - 999
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Identification and prioritization of effective food safety interventions require an understanding of the relationship between food and pathogen from farm to consumption. Critical to this cause is food attribution, the capacity to attribute cases of foodborne disease to the food vehicle or other source responsible for illness. A wide variety of food attribution approaches and data are used around the world, including the analysis of outbreak data, case-control studies, microbial subtyping and source tracking methods, and expert judgment, among others. The Food Safety Research Consortium sponsored the Food Attribution Data Workshop in October 2003 to discuss the virtues and limitations of these approaches and to identify future options for collecting food attribution data in the United States. We summarize workshop discussions and identify challenges that affect progress in this critical component of a risk-based approach to improving food safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Food -- Safety measures
KW - Pathogenic microorganisms
KW - Food consumption
KW - Foodborne diseases
KW - Epidemics
KW - United States
N1 - Accession Number: 17520801; Batz, Michael B. 1; Email Address: mbatz@rff.org; Doyle, Michael P. 2; Morris Jr., J. Glenn 3; Painter, John 4; Singh, Ruby 5; Tauxe, Robert V. 4; Taylor, Michael R. 1; Lo Fo Wong, Danilo M. A. 6; Affiliations: 1: Resources for the Future, Washington, DC, USA; 2: University of Georgia, Griffin, Georgia, USA; 3: University of Maryland School of Medicine, Baltimore, Maryland, USA; 4: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 5: Food and Drug Administration, Laurel, Maryland, USA; 6: Danish Institute for Food and Veterinary Research, Copenhagen, Denmark; Issue Info: Jul2005, Vol. 11 Issue 7, p993; Thesaurus Term: Diseases; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Food consumption; Thesaurus Term: Foodborne diseases; Thesaurus Term: Epidemics; Subject: United States; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Park, Jae Hyun
AU - Eom, Juno H.
AU - Kim, Hyung Soo
AU - Oh, Hye Young
T1 - Modulation of intracellular cytokines in draining lymph node cells following allergen and irritant
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2005/07//
VL - 20
IS - 1
M3 - Article
SP - 225
EP - 232
SN - 13826689
AB - Abstract: The murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for the assessment of the contact sensitization potential. However, there is a need to develop a non-radioisotopic endpoint for the LLNA because of the radioisotopic method''s requiring the use of special facilities. In this study, we investigated to evaluate the populations of intracellular cytokine producing cells and to analyze the expression of mRNA levels in the lymph node (LN) cells following allergen and irritant. Female Balb/c mice were treated by the topical application on the dorsum of both ears with strong sensitizers, 2,4-dinitrochlorobenzene (DNCB) and toluene diisocyanate (TDI) and a strong irritant, sodium lauryl sulfate (SLS), once daily for 3 consecutive days. The lymph node cells were harvested 72h after the final treatment. The analysis of intracellular cytokine cell in LN cells was performed with a flow cytometry. Mice were treated with DNCB and TDI showed a preferential increase in the percentage of CD4+IL-2+ cells compared with vehicle and irritant-treated mice. There was an increase in CD4+IFN-g+ cells of mice treated with DNCB and TDI, but no significant increases were observed in mice treated with SLS. Mice were treated with DNCB and TDI showed an increase in the percentage of CD4+IL-4+ cells compared with vehicle and irritant-treated mice. There was an increase in the mRNA level for interleukin 4 (IL-4) in mice treated with DNCB and TDI, but no significant increases were observed in mice treated with SLS. These results suggest that the population of interferon-gamma (IFN-g+) and IL-4+ cells on CD4+ cells and the mRNA expression for IL-4 in lymphocytes could be selectively modulated in allergen-treated mice. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPH nodes
KW - GUINEA pigs as laboratory animals
KW - CYTOKINES
KW - ALLERGENS
KW - CD4
KW - IFN-g
KW - IL-2
KW - IL-4
KW - LLNA
N1 - Accession Number: 17790053; Lee, Jong Kwon; Email Address: jkleest@yahoo.com Park, Jae Hyun 1 Eom, Juno H. 1 Kim, Hyung Soo 1 Oh, Hye Young 1; Affiliation: 1: Division of Immunotoxicology, National Institute of Toxicology Research, Korea Food and Drug Administration, 122-704 Seoul, South Korea; Source Info: Jul2005, Vol. 20 Issue 1, p225; Subject Term: LYMPH nodes; Subject Term: GUINEA pigs as laboratory animals; Subject Term: CYTOKINES; Subject Term: ALLERGENS; Author-Supplied Keyword: CD4; Author-Supplied Keyword: IFN-g; Author-Supplied Keyword: IL-2; Author-Supplied Keyword: IL-4; Author-Supplied Keyword: LLNA; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.etap.2005.02.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, Vinod P.
T1 - IV–IVC for topically applied preparations–a critical evaluation
JO - European Journal of Pharmaceutics & Biopharmaceutics
JF - European Journal of Pharmaceutics & Biopharmaceutics
Y1 - 2005/07//
VL - 60
IS - 2
M3 - Article
SP - 309
EP - 314
SN - 09396411
AB - Abstract: In vitro–in vivo correlation (IV–IVC) is the relationship between an in vitro parameter (drug release or other rheological properties/measurement such as viscosity and spreadability) and an in vivo parameter (pharmacodynamic (PD) or dermatopharmacokinetic (DPK) or other measurement). In a true sense of correlation, in vitro measurement should predict in vivo performance of the product. For topically applied preparations, one of the in vitro measurements is the drug release from the formulation and in vivo measurement is the drug concentration in the stratum corneum, DPK or the PD measurements. The in vitro release of the drug is the property of the dosage form and is a measure of product quality and ‘sameness’, especially after certain Scale-UP and Post Approval Changes after initial drug approval. To obtain an IV–IVC for a topically applied drug product is a difficult challenge. However, some success has been achieved in showing a relationship between the drug release and PD and/or DPK measurement. Interestingly, one of the in vitro rheological properties was found to relate to the observed PD and DPK response for Clobetasol dipropionate products. Different rheological properties of the two formulation products explained the difference in DPK results obtained by two laboratories for the same tretinoin gel products. In the scientific arena, it is difficult to obtain a classical IV–IVC even for orally administered products and is more so difficult for topically administered drug products. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutics & Biopharmaceutics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Physiological effect
KW - DERMATOLOGIC agents
KW - TRETINOIN
KW - RETINOIDS
KW - Dermatopharmacokinetics
KW - DPK
KW - In vitro release
KW - In vitro–in vivo correlation
KW - Pharmacodynamics
KW - Rheological properties
KW - Spreadability
N1 - Accession Number: 17916770; Shah, Vinod P. 1; Email Address: shahvi@cder.fda.gov; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, USA; Source Info: Jul2005, Vol. 60 Issue 2, p309; Subject Term: DRUGS -- Physiological effect; Subject Term: DERMATOLOGIC agents; Subject Term: TRETINOIN; Subject Term: RETINOIDS; Author-Supplied Keyword: Dermatopharmacokinetics; Author-Supplied Keyword: DPK; Author-Supplied Keyword: In vitro release; Author-Supplied Keyword: In vitro–in vivo correlation; Author-Supplied Keyword: Pharmacodynamics; Author-Supplied Keyword: Rheological properties; Author-Supplied Keyword: Spreadability; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ejpb.2004.09.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17916770&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, Chung-Tung Jordan
AU - Jensen, Kimberly L.
AU - Yen, Steven T.
T1 - Awareness of foodborne pathogens among US consumers
JO - Food Quality & Preference
JF - Food Quality & Preference
Y1 - 2005/07//
VL - 16
IS - 5
M3 - Article
SP - 401
EP - 412
SN - 09503293
AB - Abstract: Each year in the United States, microbial pathogens cause millions of cases of foodborne disease and result in many hospitalizations and deaths. Effective consumer education programs to promote safer food handling practices and other averting behaviors may benefit from consumer awareness of microbial pathogens. This paper investigates US consumers’ awareness of four major microbial pathogens (Salmonella, Campylobacter, Listeria and Escherichia coli) as food safety problems, using a multivariate probit model. The awareness varies among pathogens and the variations appear to be related to differences in the number and severity of illnesses associated with these pathogens. Our findings suggest that awareness of microbial pathogens is associated with food safety perceptions, awareness of potentially risky foods and substances associated with potential food safety hazards, food safety related behaviors, and demographics. There are differentiated effects of variables on awareness of the four pathogens. [Copyright &y& Elsevier]
AB - Copyright of Food Quality & Preference is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - FOOD handling
KW - FOOD industry
KW - ENTEROBACTERIACEAE
KW - Consumer awareness
KW - Foodborne pathogens
KW - Multivariate probit
N1 - Accession Number: 17034966; Lin, Chung-Tung Jordan 1; Email Address: chung-tung.lin@cfsan.fda.gov Jensen, Kimberly L. 2; Email Address: kjensen@utk.edu Yen, Steven T. 2; Email Address: syen@utk.edu; Affiliation: 1: Division of Market Studies, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, United States 2: Department of Agricultural Economics, University of Tennessee, Knoxville, TN 37996-4518, United States; Source Info: Jul2005, Vol. 16 Issue 5, p401; Subject Term: PATHOGENIC microorganisms; Subject Term: FOOD handling; Subject Term: FOOD industry; Subject Term: ENTEROBACTERIACEAE; Author-Supplied Keyword: Consumer awareness; Author-Supplied Keyword: Foodborne pathogens; Author-Supplied Keyword: Multivariate probit; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.foodqual.2004.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stuart, Bruce
AU - Briesacher, Becky A.
AU - Shea, Dennis G.
AU - Cooper, Barbara
AU - Baysac, Fatima S.
AU - Limcangco, M. Rhona
T1 - Riding The Rollercoaster: The Ups And Downs In Out-Of-Pocket Spending Under The Standard Medicare Drug Benefit.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/07//Jul/Aug2005
VL - 24
IS - 4
M3 - Article
SP - 1022
EP - 1031
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - This study projects how much Medicare beneficiaries who sign up for the standard Part D drug benefit in 2006 will pay in quarterly out-of-pocket payments through 2008. In the first year we estimate that about 38 percent of enrollees will hit the benefit's no-coverage zone, known as the "doughnut hole," and that 14 percent will exceed the catastrophic threshold. Because drug spending is highly persistent overtime, beneficiaries who experience the biggest gaps in coverage are likely to do so year after year, with potentially serious financial consequences. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE beneficiaries
KW - HEALTH insurance
KW - MEDICAL policy
KW - DRUGS
KW - MEDICAL care costs
KW - PUBLIC health
N1 - Accession Number: 17582436; Stuart, Bruce 1; Email Address: BStuart@rxumaryland.edu Briesacher, Becky A. 2 Shea, Dennis G. 3 Cooper, Barbara Baysac, Fatima S. 4 Limcangco, M. Rhona 5; Affiliation: 1: Professor and director of the Peter Lamy Center on Drug Therapy and Aging, University of Maryland, Baltimore. 2: Assistant professor, University of Massachusetts Medical School, Division of Geriatric Medicine, Worcester 3: Professor and chair of the Department of Health Policy and Administration, Pennsylvania State University, University Park 4: Doctoral candidate, Department of Pharmaceutical Health Services Research, University of Maryland, Baltimore. 5: Research analyst, Agency for Healthcare Research and Quality in Rockville, Maryland; Source Info: Jul/Aug2005, Vol. 24 Issue 4, p1022; Subject Term: MEDICARE beneficiaries; Subject Term: HEALTH insurance; Subject Term: MEDICAL policy; Subject Term: DRUGS; Subject Term: MEDICAL care costs; Subject Term: PUBLIC health; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Document Type: Article
L3 - 10.1377/hlthaff.24.4.1022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17582436&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106506608
T1 - Use and costs of bariatric surgery and prescription weight-loss medications: treatment for obesity has skyrocketed since 1998, but coverage policies remain uneven across insurers.
AU - Encinosa WE
AU - Bernard DM
AU - Steiner CA
AU - Chen C
Y1 - 2005/07//Jul/Aug2005
N1 - Accession Number: 106506608. Language: English. Entry Date: 20060519. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 8303128.
KW - Antiobesity Agents -- Economics
KW - Bariatric Surgery -- Economics
KW - Obesity -- Drug Therapy
KW - Obesity -- Surgery
KW - Adolescence
KW - Adult
KW - Bariatric Surgery -- Trends
KW - Costs and Cost Analysis
KW - Female
KW - Health Care Costs
KW - Health Facility Costs
KW - Insurance, Health -- Economics
KW - Length of Stay -- Economics
KW - Male
KW - Middle Age
KW - Sex Factors
KW - Funding Source
KW - Human
SP - 1039
EP - 1046
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 24
IS - 4
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - The extent of use of bariatric surgery and weight-loss medications is unknown. Using the Nationwide Inpatient Sample, we estimate that the number of bariatric surgeries grew 400 percent between 1998 and 2002; such surgeries were performed on 0.6 percent of the 11.5 million adults clinically eligible in 2002. Hospital costs for bariatric surgery grew sixfold to $948 million in 2002. The inpatient death rate declined 64 percent. Among employers that covered weight-loss drugs in 2002, less than 2.4 percent of adults clinically eligible for these drugs used them, with average annual spending of $304 per user.
SN - 0278-2715
AD - Senior Economist, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD; wencinos@ahrq.gov
U2 - PMID: 16012144.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106383536
T1 - Ambulatory care visits for treating adverse drug effects in the United States, 1995-2001.
AU - Zhan C
AU - Arispe I
AU - Kelley E
AU - Ding T
AU - Burt CW
AU - Shinogle J
AU - Stryer D
Y1 - 2005/07//2005 Jul
N1 - Accession Number: 106383536. Language: English. Entry Date: 20060120. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 101238023.
KW - Adverse Drug Event
KW - Ambulatory Care
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Aged
KW - Analysis of Variance
KW - Child
KW - Child, Preschool
KW - Data Analysis Software
KW - Emergency Service
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Age
KW - Office Visits
KW - Outpatient Service
KW - Outpatients
KW - Post Hoc Analysis
KW - Practitioner's Office
KW - Prevalence
KW - Probability Sample
KW - Prospective Studies
KW - Sex Factors
KW - Surveys
KW - Systematic Random Sample
KW - T-Tests
KW - United States
KW - Human
SP - 372
EP - 378
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 31
IS - 7
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - BACKGROUND: Adverse d[rug events (ADEs) are a well-recognized patient safety 4concern, but their magnitude is unknown. Ambulatory viisits for treating adverse drug effects (VADEs) as recordeed in national surveys offer an alternative way to estimatte the national prevalence of ADEs because each VA]DE indicates that an ADE occurred and was seriousenough to require care. METHODS: A nationallyrepresentative sample of visits to physician offices, hospital outpatient departments, and emergency departments was analyzed. VADEs were identified as tthe first-listed cause of injury. RESULTS: In 2001, there Awere 4.3 million VADEs in the United States, averaging 15 visits per 1,000 population. VADE rates at physicianoffices, hospital outpatient departments, and hospittal emergency departments were at 3.7, 3.4, and 7.3 lper 1,000 visits, respectively. There was an upward tr'end in the total number of VADEs from 1995 to 2001 ((p < .05), but the increases in VADEs per 1000 visits an.d per 1,000 population were not statistically significant. VADEs were lower in children younger than 15 and higher in the elderly aged 65-74 than in adults aged 225-44 (p < .01) and were more frequent in females than irn males (p < .05). DISCUSSION: Although methodologically conservative, the study suggests that ADEs are a significant threat to patient safety in the United States.
SN - 1553-7250
AD - Staff Service Fellow, Intramural, National Healthcare Quality Report, Patient Safety, Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services, Rockville, Maryland; czhan@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ruby Singh
AU - Carl M. Schroeder
AU - Jianghong Meng
AU - David G. White
AU - Patrick F. McDermott
AU - David D. Wagner
AU - Hanchun Yang
AU - Shabbir Simjee
AU - Chitrita DebRoy
AU - Robert D. Walker
AU - Shaohua Zhao
T1 - Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animals.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2005/07//
VL - 56
IS - 1
M3 - Article
SP - 216
EP - 219
SN - 03057453
N1 - Accession Number: 18250140; Ruby Singh 1; Carl M. Schroeder 2; Jianghong Meng 2; David G. White 1; Patrick F. McDermott 1; David D. Wagner 1; Hanchun Yang 2; Shabbir Simjee 1; Chitrita DebRoy 3; Robert D. Walker 1; Shaohua Zhao 1; Affiliations: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA;; 2: on of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA; , 1 , Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA;; 3: on of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA; , 1 , Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; , 2 , Gastroenteric Disease Center, The Pennsylvania State University, University Park, PA, USA; Issue Info: Jul2005, Vol. 56 Issue 1, p216; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Heidi S. Rupp
AU - Stuart, James S.
AU - Hurlbut, Jeffrey A.
T1 - Liquid Chromatography/Tandem Mass Spectrometry Analysis of Chloramphenicol in Cooked Crab Meat.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/07//Jul/Aug2005
VL - 88
IS - 4
M3 - Article
SP - 1155
EP - 1159
SN - 10603271
AB - Examines the utility of liquid chromatography/tandem mass spectrometry for the extraction, cleanup, determination and confirmation of chloramphenicol (CAP) in cooked crab meat. Pulverization of cooked crab meat with dry ice; Extraction of the CAP into ethyl acetate; Average absolute recoveries of the drug.
KW - CHLORAMPHENICOL
KW - DRUGS -- Analysis
KW - LIQUID chromatography
KW - MASS spectrometry
KW - PHARMACEUTICAL chemistry
N1 - Accession Number: 17875801; Heidi S. Rupp 1; Email Address: heidi.rupp@fda.gov Stuart, James S. 2 Hurlbut, Jeffrey A. 2; Affiliation: 1: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Dr SE, Bothell, WA 98021 2: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, WA 98021; Source Info: Jul/Aug2005, Vol. 88 Issue 4, p1155; Subject Term: CHLORAMPHENICOL; Subject Term: DRUGS -- Analysis; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: PHARMACEUTICAL chemistry; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - Upper and Lower Bounds for a Serial Dilution Test.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/07//Jul/Aug2005
VL - 88
IS - 4
M3 - Article
SP - 1227
EP - 1231
SN - 10603271
AB - Examines the usability of a Poisson-binomial model in estimating the concentration of a target microbe from a serial dilution test. Likelihood for the procedure to produce an equation whose solution equals the estimate of the concentration; Accuracy of the calculations using the equations; Inequalities in the geometric mean of the upper and lower bounds.
KW - POISSON'S equation
KW - EQUATIONS
KW - DILUTION
KW - ANALYTICAL chemistry
KW - CHEMISTRY
N1 - Accession Number: 17875812; Blodgett, Robert J. 1; Email Address: Robert.Blodgett@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, HFS-705, Rm sD-011 Paint Branch Pkwy, College Park, MD 20740; Source Info: Jul/Aug2005, Vol. 88 Issue 4, p1227; Subject Term: POISSON'S equation; Subject Term: EQUATIONS; Subject Term: DILUTION; Subject Term: ANALYTICAL chemistry; Subject Term: CHEMISTRY; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Othumpangat, Sreekumar
AU - Kashon, Michael
AU - Joseph, Pius
T1 - Eukaryotic Translation Initiation Factor 4E Is a Cellular Target for Toxicity and Death Due to Exposure to Cadmium Chloride.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/07//7/1/2005
VL - 280
IS - 26
M3 - Article
SP - 25162
EP - 25169
SN - 00219258
AB - Whether translation initiation factor 4E (eIF4E), the mRNA cap binding and rate-limiting factor required for translation, is a target for cytotoxicity and cell death induced by cadmium, a human carcinogen, was investigated. Exposure of human cell lines, HCT15, PLC/PR/5, HeLa, and Chang, to cadmium chloride resulted in cytotoxicity and cell death, and this was associated with a significant decrease in eIF4E protein levels. Similarly, specific silencing of the expression of the eIF4E gene, caused by a small interfering RNA, resulted in significant cytotoxicity and cell death. On the other hand, overexpression of the eIF4E gene was protective against the cadmium-induced cytotoxicity and cell death. Further studies revealed the absence of alterations in the eIF4E mRNA level in the cadmium-treated cells despite their decreased eIF4E protein level. In addition, exposure of cells to cadmium resulted in enhanced ubiquitination of eIF4E protein while inhibitors of proteasome activity reversed the cadmium-induced decrease of eIF4E protein. Exposure of cells to cadmium, as well as the specific silencing of eIF4E gene, also resulted in decreased cellular levels of cyclin D1, a critical cell cycle and growth regulating gene, suggesting that the observed inhibition of cyclin D1 gene expression in the cadmium-treated cells is most likely due to decreased cellular level of eIF4E. Taken together, our results demonstrate that the exposure of cells to cadmium chloride resulted in cytotoxicity and cell death due to enhanced ubiquitination and consequent proteolysis of eIF4E protein, which in turn diminished cellular levels of critical genes such as cyclin D1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM
KW - CADMIUM compounds
KW - MESSENGER RNA
KW - CELL death
KW - CELL-mediated cytotoxicity
KW - CELL lines
KW - UBIQUITIN
N1 - Accession Number: 17548881; Othumpangat, Sreekumar 1 Kashon, Michael 2 Joseph, Pius 1; Email Address: pcj5@cdc.gov; Affiliation: 1: Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia 26505; Source Info: 7/1/2005, Vol. 280 Issue 26, p25162; Subject Term: CADMIUM; Subject Term: CADMIUM compounds; Subject Term: MESSENGER RNA; Subject Term: CELL death; Subject Term: CELL-mediated cytotoxicity; Subject Term: CELL lines; Subject Term: UBIQUITIN; Number of Pages: 8p; Illustrations: 7 Black and White Photographs, 1 Diagram, 5 Graphs; Document Type: Article
L3 - 10.1074/jbc.M414303200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kezirian, Guy M.
AU - Drum, Bruce
AU - Eydelman, Malvina
T1 - Systematic evaluation of wavefront-guided outcomes
JO - Journal of Cataract & Refractive Surgery
JF - Journal of Cataract & Refractive Surgery
Y1 - 2005/07//
VL - 31
IS - 7
M3 - Article
SP - 1306
EP - 1313
SN - 08863350
AB - Purpose: To present a format for reporting outcomes of aberrometer-guided refractive procedures. Setting: SurgiVision Consultants, Inc., Scottsdale, Arizona, and Food and Drug Administration, Center for Devices and Radiological Health, Rockland, Maryland, USA. Methods: Reports of standard refractive and visual outcomes (uncorrected visual acuity, manifest refractive spherical equivalent, best spectacle-corrected visual acuity) should be provided for any refractive surgery report. Comparison of postoperative uncorrected visual acuity to preoperative best spectacle-corrected visual acuity should be included. Aberration reports should convert 2nd-order terms to refractions (measured in diopters) and use standard refractive reporting methods. Changes in coma, spherical aberration, and root-mean-square changes should be described using statistical methods for aggregate data. Underlying statistics should be reported. Results: Aberration changes are well described by the mean error of the attempted versus achieved outcomes, comparison of the mean changes, and stability over time. Ancillary plots include histogram representation of the postoperative scores. Additional reports of visual function should be included, as appropriate. Conclusion: Use of standardized tables and graphs permits qualitative and quantitative comparison of outcomes of refractive treatment with wavefront-guided lasers. Modifications of the recommended formats can be expected over time. [Copyright &y& Elsevier]
AB - Copyright of Journal of Cataract & Refractive Surgery is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPHTHALMIC surgery
KW - VISUAL acuity
KW - HOLOGRAPHY
KW - LASERS
N1 - Accession Number: 18234218; Kezirian, Guy M.; Email Address: Guy1000@SurgiVision.net Drum, Bruce 1 Eydelman, Malvina 1; Affiliation: 1: From SurgiVision Consultants, Inc. (Kezirian), Scottsdale, Arizona, and the U.S. Food and Drug Administration, Center for Devices and Radiologic Health (Drum), and Department of Health and Human Services, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jul2005, Vol. 31 Issue 7, p1306; Subject Term: OPHTHALMIC surgery; Subject Term: VISUAL acuity; Subject Term: HOLOGRAPHY; Subject Term: LASERS; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jcrs.2005.01.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adams, Ann M.
AU - Ton, My N.
AU - Wekell, Marleen M.
AU - MacKenzie, Alan P.
AU - Dong, Faye M.
T1 - Survival of Anisakis simplex in Arrowtooth Flounder (Atheresthes stomia) during Frozen Storage.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/07//
VL - 68
IS - 7
M3 - Article
SP - 1441
EP - 1446
SN - 0362028X
AB - Survival of naturally occurring larvae of Anisakis simplex in fresh arrowtooth flounder (Atheresthes stomia) was determined after storage for specified periods at four freezing temperatures. All larvae were killed by 96, 60, 12, and 9 h at temperatures of -15, -20, -30, and -40°C, respectively. The average percentages of live larvae per fillet at the next shortest holding time were as follows: 72 h at 15°C. 0 to 3%; 48 h at 20°C, 11 to 30%;9hat 30°C, 5%; and 6 h at 40°C, 0 to 3%. Larval survival was directly related to fillet thickness or weight (P < 0.05). Larval death was directly correlated to freezing temperatures. Holding time necessary to kill larval nematodes decreased as storage temperature decreased. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anisakidae
KW - Flatfishes
KW - Cryobiology
KW - Anisakis
KW - Frozen fish
KW - Cold (Temperature) -- Physiological effect
N1 - Accession Number: 17648066; Adams, Ann M. 1; Email Address: aadams@ora.fda.gov; Ton, My N. 2; Wekell, Marleen M. 1; MacKenzie, Alan P. 2; Dong, Faye M. 2,3; Affiliations: 1: U.S. Food and Drug Administration, Seafood Producers Research Center, P.O. Box 3012, 22201 23rd Drive S.E., Botherll, Washington 98041-3012; 2: School of Aquatic and Fishery Sciences, University of Washington, 3707 Brooklyn Avenue, Seattle, Washington 98105-6715, USA; 3: Department of Food Science and Human Nutrition, University of Illinois, 260 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL 61801, USA; Issue Info: Jul2005, Vol. 68 Issue 7, p1441; Thesaurus Term: Anisakidae; Thesaurus Term: Flatfishes; Thesaurus Term: Cryobiology; Subject Term: Anisakis; Subject Term: Frozen fish; Subject Term: Cold (Temperature) -- Physiological effect; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 424460 Fish and Seafood Merchant Wholesalers; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; NAICS/Industry Codes: 424420 Packaged Frozen Food Merchant Wholesalers; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Meldrum, R. J.
AU - Tucker, D.
AU - Smith, R. M. M.
AU - Edwards, C.
T1 - Survey of Salmonella and Campylobacter Contamination of Whole, Raw Poultry on Retail Sale in Wales in 2003.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/07//
VL - 68
IS - 7
M3 - Article
SP - 1447
EP - 1449
SN - 0362028X
AB - A survey of the Salmonella and Campylobacter contamination of raw, whole chickens available to consumers in Wales was performed between March and December 2003. In total, 736 samples were taken, and overall contamination rates of 73.1% for Campylobacter and 5.7% for Salmonella were found. This survey follows a survey performed during 2001 to 2002 by Welsh local authorities and the National Public Health Service for Wales that established updated baseline rates for both pathogens in raw, whole chicken available to consumers in Wales. This survey indicated no difference in Campylobacter rates between fresh and frozen samples or between samples taken from retailers and local butchers, but significant differences existed in Salmonella rates between fresh and frozen samples and between those sampled from retailers and butchers, with frozen chickens and samples taken from retailers having significantly higher rates. However, the difference in Salmonella isolation rate between retailers and butchers was found to be due to the differences in the proportions of fresh and frozen chickens sampled from these locations, with a significantly higher number of frozen chickens (with a higher Salmonella rate) being sampled from retailers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Campylobacter
KW - Microbial contamination
KW - Pathogenic microorganisms
KW - Public health
KW - Public health surveillance
KW - Wales
N1 - Accession Number: 17648067; Meldrum, R. J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Tucker, D. 1; Smith, R. M. M. 2; Edwards, C. 3; Affiliations: 1: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK; 2: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Abton House, Wedal Road, Cardiff CF14 3QX, UK; 3: Caerphilly County Borough Council, Council Offices, Pontllanfraidd, Blackwood MP12 2YW, UK; Issue Info: Jul2005, Vol. 68 Issue 7, p1447; Thesaurus Term: Salmonella; Thesaurus Term: Campylobacter; Thesaurus Term: Microbial contamination; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Public health; Subject Term: Public health surveillance; Subject: Wales; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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ER -
TY - JOUR
AU - Yi-Cheng Su
AU - Jingyun Duan
AU - Wen-Hsin Wu
T1 - Selectivity and Specificity of a Chromogenic Medium for Detecting Vibrio parahaemolyticus.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/07//
VL - 68
IS - 7
M3 - Article
SP - 1454
EP - 1456
SN - 0362028X
AB - The thiosulfate-citrate bile salts-sucrose agar (TCBS) used in the most-probable-number method for detecting Vibrio parahaemolyticus cannot differentiate growth of V. parahaemolyticus from Vibrio vulnificus or Vibrio mimicus. This study examined the selectivity and specificity of Bio-Chrome Vibrio medium (BCVM), a chromogenic medium that detects V. parahaemolyticus on the basis of the formation of distinct purple colonies on the medium. A panel consisting of 221 strains of bacteria, including 179 Vibrio spp. and 42 non-Vibrio spp., were examined for their ability to grow and produce colored colonies on BCVM. Growth of Salmonella, Shigella, Escherichia coli, Enterobacter cloacae, Yersinia enterocolitica, and Aeromonas was inhibited by both BCVM and TCBS. All 148 strains of V. parahaemolyticus grew on BCVM, and 145 of them produced purple colonies. The remaining 31 Vibrio spp., except one strain of Vibrio fluvialis, were either unable to grow or produced blue-green or white colonies on BCVM. Bio-Chrome Vibrio medium was capable of differentiating V. parahaemolyticus from other species, including V. vulnificus and V. mimicus. Further studies are needed to evaluate the sensitivity and specificity of BCVM for detecting V. parahaemolyticus in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Food poisoning
KW - Bacteriology
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Aeromonas
N1 - Accession Number: 17648069; Yi-Cheng Su 1; Email Address: yi-cheng.su@oregonstate.edu; Jingyun Duan 1; Wen-Hsin Wu 2; Affiliations: 1: OSU Seafood Laboratory, Oregon State University, 2001 Marine Drive, Room 253, Astoria, Oregon 97103; 2: Seafood Product Research Center, Pacific Regional Laboratory Northwest, Office of Regulatory Affairs, U.S. Food and Drug Administration, Bothell, Washington 98021, USA; Issue Info: Jul2005, Vol. 68 Issue 7, p1454; Thesaurus Term: Escherichia coli; Thesaurus Term: Food poisoning; Thesaurus Term: Bacteriology; Subject Term: Vibrio parahaemolyticus; Subject Term: Vibrio vulnificus; Subject Term: Aeromonas; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106499018
T1 - Focus on patient safety. Patient safety in nursing practice.
AU - Clancy CM
AU - Farquhar MB
AU - Sharp BAC
Y1 - 2005/07//Jul-Sep2005
N1 - Accession Number: 106499018. Language: English. Entry Date: 20050812. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Nursing Practice
KW - Patient Safety
KW - Health Care Errors
KW - Information Resources
KW - United States Agency for Healthcare Research and Quality
KW - World Wide Web
SP - 193
EP - 197
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 20
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, Rockville, Md
U2 - PMID: 15965381.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106498959
T1 - Pesticide contamination inside farm and nonfarm homes.
AU - Curwin BD
AU - Hein MJ
AU - Sanderson WT
AU - Nishioka MG
AU - Reynolds SJ
AU - Ward EM
AU - Alavanja MC
Y1 - 2005/07//
N1 - Accession Number: 106498959. Language: English. Entry Date: 20050812. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D57-8. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Home Environment
KW - Pesticides -- Adverse Effects
KW - Data Analysis Software
KW - Dust
KW - Education, Continuing (Credit)
KW - Environmental Exposure
KW - Iowa
KW - Human
SP - 357
EP - 367
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Twenty-five farm (F) households and 25 nonfarm (NF) households in Iowa were enrolled in a study investigating agricultural pesticide contamination inside homes. Air, surface wipe, and dust samples were collected. Samples from 39 homes (20 F and 19 NF) were analyzed for atrazine, metolachlor, acetochlor, alachlor, and chlorpyrifos. Samples from 11 homes (5 F and 6 NF) were analyzed for glyphosate and 2,4-Dichlorophenoxyac etic acid (2,4-D). Greater than 88% of the air and greater than 74% of the wipe samples were below the limit of detection (LOD). Among the air and wipe samples, chlorpyrifos was detected most frequently in homes. In the dust samples, all the pesticides were detected in greater than 50% of the samples except acetochlor and alachlor, which were detected in less than 30% of the samples. Pesticides in dust samples were detected more often in farm homes except 2,4-D, which was detected in 100% of the farm and nonfarm home samples. The average concentration in dust was higher in farm homes versus nonfarm homes for each pesticide. Further analysis of the data was limited to those pesticides with at least 50% of the dust samples above the LOD. All farms that sprayed a pesticide had higher levels of that pesticide in dust than both farms that did not spray that pesticide and nonfarms; however, only atrazine and metolachlor were significantly higher. The adjusted geometric mean pesticide concentration in dust for farms that sprayed a particular pesticide ranged from 94 to 1300 ng/g compared with 12 to 1000 ng/g for farms that did not spray a particular pesticide, and 2.4 to 320 ng/g for nonfarms. The distributions of the pesticides throughout the various rooms sampled suggest that the strictly agricultural herbicides atrazine and metolachlor are potentially being brought into the home on the farmer's shoes and clothing. These herbicides are not applied in or around the home but they appear to be getting into the home para-occupationally. For agricultural pesticides, take-home exposure may be an important source of home contamination.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226; bcurwin@cdc.gov
U2 - PMID: 16020099.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Yong-Hak
AU - Pothuluri, Jairaj V.
AU - Cerniglia, Carl E.
T1 - Voltammetric investigation of macrolides by an HPLC-coulometric assay
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2005/07//
VL - 38
IS - 3
M3 - Article
SP - 390
EP - 396
SN - 07317085
AB - Abstract: Voltammograms of macrolides, including anhydroerythromycin A, azithromycin, erythromycin A, erythromycin A enol ether, pseudoerythromycin A enol ether, oleandomycin and tylosin have been investigated using a dual electrode cell in combination with a high-throughput LC method. The half-wave potentials (E 1/2) of the seven macrolides investigated ranged from 0.734 to 0.866V, and the current responses reached the maxima at over 1.0V. The current response of the downstream electrode displayed a non-linear behavior at high potentials over +0.75V, probably because of polarization of solvent components, e.g., water. The HPLC-coulometric assay was optimized with the potentials of the upstream and downstream electrodes at +0.65 and +0.85V, respectively. This method is suitable for detection of 14- and 15-membered macrolides (sensitivity<0.05μgml−1), but not for a 16-membered macrolide, tylosin (sensitivity>0.1μgml−1). The assay shows interferences from biomatrices in rat''s blood plasma and serum, and human urine, but they were effectively removed by a cold acetonitrile extraction method. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROLIDE antibiotics
KW - ANTIBIOTICS
KW - ERYTHROMYCIN
KW - ANTIBACTERIAL agents
KW - Coulometric assay
KW - HPLC
KW - Macrolides
KW - Voltammogram
N1 - Accession Number: 17951886; Kim, Yong-Hak 1 Pothuluri, Jairaj V. 1 Cerniglia, Carl E.; Email Address: ccerniglia@nctr.fda.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jul2005, Vol. 38 Issue 3, p390; Subject Term: MACROLIDE antibiotics; Subject Term: ANTIBIOTICS; Subject Term: ERYTHROMYCIN; Subject Term: ANTIBACTERIAL agents; Author-Supplied Keyword: Coulometric assay; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Macrolides; Author-Supplied Keyword: Voltammogram; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2005.01.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verbeeck, R. K.
AU - Junginger, H. E.
AU - Midha, K. K.
AU - Shah, V. P.
AU - Barends, D. M.
T1 - Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: Chloroquine phosphate, chloroquine sulfate, and chloroquine hydrochloride.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2005/07//
VL - 94
IS - 7
M3 - Article
SP - 1389
EP - 1395
SN - 00223549
AB - Literature data on the properties of chloroquine phosphate, chloroquine sulfate, and chloroquine hydrochloride related to the Biopharmaceutics Classification System (BCS) are reviewed. The available information indicates that these chloroquine salts can be classified as highly soluble and highly permeable, i.e., BCS class I. The qualitative composition of immediate release (IR) tablets containing these Active Pharmaceutical Ingredients (APIs) with a Marketing Authorization (MA) in Belgium (BE), Germany (DE), Finland (FI), and The Netherlands (NL) is provided. In view of these MA's and the critical therapeutic indication of chloroquine, it is assumed that the registration authorities had evidence that these formulations are bioequivalent to the innovator. It is concluded that IR tablets formulated with these excipients are candidates for a biowaiver. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:1389–1395, 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLOROQUINE
KW - BIOPHARMACEUTICS
KW - SALTS
KW - TABLETS (Medicine)
KW - EXCIPIENTS
KW - ANTIMALARIALS
KW - absorption
KW - BCS
KW - chloroquine
KW - permeability
KW - solubility
N1 - Accession Number: 22171286; Verbeeck, R. K. 1 Junginger, H. E. 2 Midha, K. K. 3 Shah, V. P. 4 Barends, D. M. 5; Email Address: dirk.barends@rivm.nl; Affiliation: 1: Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa 2: Leiden/Amsterdam Center for Drug Research, Leiden University, Division of Pharmaceutical Technology, Leiden, The Netherlands 3: University of Saskatchewan, Saskatoon, Saskatchewan, Canada 4: Center of Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 5: RIVM—National Institute for Public Health and the Environment, Laboratory for Quality Control of Medicines, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Source Info: Jul2005, Vol. 94 Issue 7, p1389; Subject Term: CHLOROQUINE; Subject Term: BIOPHARMACEUTICS; Subject Term: SALTS; Subject Term: TABLETS (Medicine); Subject Term: EXCIPIENTS; Subject Term: ANTIMALARIALS; Author-Supplied Keyword: absorption; Author-Supplied Keyword: BCS; Author-Supplied Keyword: chloroquine; Author-Supplied Keyword: permeability; Author-Supplied Keyword: solubility; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1002/jps.20343
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valentin, Jean-Pierre
AU - Bass, Alan S.
AU - Atrakchi, Aisar
AU - Olejniczak, Klaus
AU - Kannosuke, Fujimori
T1 - Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A
JO - Journal of Pharmacological & Toxicological Methods
JF - Journal of Pharmacological & Toxicological Methods
Y1 - 2005/07//
VL - 52
IS - 1
M3 - Article
SP - 22
EP - 29
SN - 10568719
AB - Abstract: The International Conference on Harmonization, Topic S7A guidance (ICH S7A) on safety pharmacology for human pharmaceuticals has been in effect for 3 years in Europe, the United States and Japan. Surveys of the pharmaceutical industry, regulatory agencies and the audience attending the 4th Annual Meeting of the Safety Pharmacology Society have helped identify and address areas of controversy, as well as those challenges that have emerged since implementation of the guidance worldwide. Overall, ICH S7A has been successfully implemented. The guidance provides for “Good Laboratory Practice” compliant “safety pharmacology core battery” of studies that are generally performed prior to first administration to humans. The approach is science-driven and specifies the use of robust and sophisticated in vitro and/or in vivo assays. There are, however, some areas that require further refinement/clarification such as the specifics of study design including the selection of dose/concentration, choice of species, modeling of the temporal pharmacodynamic changes in relation to pharmacokinetic profile of parent drug and major metabolites, use of an appropriate sample size, statistical power analysis as a means of demonstrating the sensitivity of the model system, testing of human-specific metabolites and demonstrating not only the model''s sensitivity, but also its specificity for predicting adverse events in humans. There was also discussion of when these studies are needed in relation to the clinical development plan. Representatives from the pharmaceutical industry and regulatory agencies see the implementation of ICH S7A as a major step forward towards identifying the risk to Phase 1 and 2 volunteers and patients. It remains to be seen, however, whether and in what ways the ICH S7A-based strategy will contribute to the modification of the integrated risk assessment during the latter stages of clinical development or once drugs have been introduced to the marketplace. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmacological & Toxicological Methods is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacology
KW - Medical sciences
KW - Pharmaceutical industry
KW - Surveys
KW - central nervous system ( CNS )
KW - food and drug administration ( FDA )
KW - good laboratory practice ( GLP )
KW - good manufacturing practice ( GMP )
KW - international conference on harmonization ( ICH )
KW - investigational new drug ( IND )
KW - new drug application ( NDA )
KW - pharmaceuticals and medical devices agency ( PMDA )
N1 - Accession Number: 18151331; Valentin, Jean-Pierre 1; Email Address: jean-pierre.valentin@astrazeneca.com; Bass, Alan S. 2; Atrakchi, Aisar 3; Olejniczak, Klaus 4; Kannosuke, Fujimori 5; Affiliations: 1: Department of Safety Pharmacology, Safety Assessment UK, AstraZeneca R&D Alderley Park, Macclesfield, Cheshire SK10 4TG, UK; 2: Investigational and Regulatory Safety Pharmacology, Schering-Plough Research Institute, 2015 Galloping Hill Road, K15-2-2770, Kenilworth, NJ 07033-0539, USA; 3: U.S. Food and Drug Administration (FDA), 5600 Fishers Lane, CDER-HFD120, Rockville, MD-20857, USA; 4: Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, D-53175 Bonn, Germany; 5: Pharmaceuticals and Medical Devices Agency, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013, Japan; Issue Info: Jul2005, Vol. 52 Issue 1, p22; Thesaurus Term: Pharmacology; Subject Term: Medical sciences; Subject Term: Pharmaceutical industry; Subject Term: Surveys; Author-Supplied Keyword: central nervous system ( CNS ); Author-Supplied Keyword: food and drug administration ( FDA ); Author-Supplied Keyword: good laboratory practice ( GLP ); Author-Supplied Keyword: good manufacturing practice ( GMP ); Author-Supplied Keyword: international conference on harmonization ( ICH ); Author-Supplied Keyword: investigational new drug ( IND ); Author-Supplied Keyword: new drug application ( NDA ); Author-Supplied Keyword: pharmaceuticals and medical devices agency ( PMDA ); NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vascn.2005.04.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Momosaki, S.
AU - Umemura, T.
AU - Scudamore, C. H.
AU - Kojiro, M.
AU - Alter, H. J.
AU - Tabor, E.
T1 - SEN virus infection in patients with hepatocellular carcinoma.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2005/07//
VL - 12
IS - 4
M3 - Article
SP - 435
EP - 438
PB - Wiley-Blackwell
SN - 13520504
AB - Although most cases of hepatocellular carcinoma (HCC) are associated with either the hepatitis B or C viruses (HBV, HCV), about 10–20% of HCCs occur in patients with chronic hepatitis that is aetiologically undefined. The aim of the present study was to determine the prevalence of the transfusion-transmitted SEN virus (SEN-V) in patients with HCC, including those patients who do not otherwise appear to be infected with HBV or HCV. Fragments of SEN-V subtypes D and H were amplified separately by PCR from the sera of 50 patients with HCC (31 from Canada and 19 from Japan) as well as from HCC and adjacent nontumourous liver tissues from eight of the Canadian patients. SEN-V DNA was found in the serum of 10 of 31 (32%) Canadian patients and eight of 19 (42%) Japanese patients [overall, 18 of 50 (36%) HCC patients]. SEN-V DNA was detected in the serum of 10 of 23 (43%) HCC patients with antibody to HCV (anti-HCV), six of 11 (55%) with hepatitis B surface antigen (HBsAg), and two of 16 (12%) without detectable anti-HCV or HBsAg. Twenty-three HCC patients in this study had ‘silent HBV,’ characterized by the detection of HBV DNA in the absence of HBsAg; eight of these (35%) also had SEN-V infections. SEN-V DNA was detected in HCC patients most typically in those with coexistent HBV or HCV infection. SEN-V was found in only one of seven HCC patients without HBV (without HBsAg or HBV DNA) or HCV and thus does not appear to be an important cause of ‘cryptogenic’ HCC. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Cancer
KW - CANCER patients
KW - DNA
KW - HEPATITIS B
KW - VIRAL hepatitis
KW - GENES
KW - ‘silent’ hepatitis B virus
KW - hepatocellular carcinoma
KW - SEN virus
N1 - Accession Number: 17400792; Momosaki, S. Umemura, T. 1 Scudamore, C. H. 2 Kojiro, M. 3 Alter, H. J. 1 Tabor, E. 4; Affiliation: 1: Division of Transfusion Medicine, National Institutes of Health, Bethesda, MD, USA 2: Department of Surgery, University of British Columbia, Vancouver, BC, Canada 3: Department of Pathology, Kurume University, Kurume, Japan 4: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, MD, USA; Source Info: Jul2005, Vol. 12 Issue 4, p435; Subject Term: LIVER -- Cancer; Subject Term: CANCER patients; Subject Term: DNA; Subject Term: HEPATITIS B; Subject Term: VIRAL hepatitis; Subject Term: GENES; Author-Supplied Keyword: ‘silent’ hepatitis B virus; Author-Supplied Keyword: hepatocellular carcinoma; Author-Supplied Keyword: SEN virus; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1365-2893.2005.00618.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hu, Yuan
AU - Hirshfield, Irvin
T1 - Rapid approach to identify an unrecognized viral agent
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2005/07//
VL - 127
IS - 1
M3 - Article
SP - 80
EP - 86
SN - 01660934
AB - Abstract: For epidemic control, rapid identification and characterization of the responsible unknown agent are crucial. To address this critical question, a method was developed for virus discovery based on a flexible nested-PCR subtraction hybridization. As a positive control, we used hepatitis C virus as a hypothetical unrecognized virus and “discover” it in the sample. Using template-switching universal long-PCR to produce large quantities of cDNA, our nested-PCR-based subtractive hybridization coupled with a single-strand deletion technology removed most of the common cDNA. Following subtraction hybridization, a cDNA library was constructed and displayed by differential reverse dot blot hybridization. This new genomic subtraction hybridization method will be ideally suited to identify rapidly any previously unrecognized viral agent. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C
KW - HEPATITIS C virus
KW - MESSENGER RNA
KW - CIRCULAR DNA
KW - POLYMERASE chain reaction
KW - cDNA
KW - cDNA library
KW - Long-PCR
KW - mRNA
KW - Mung bean nuclease
KW - Nested-PCR
KW - Subtraction hybridization
KW - Unrecognized viral agents
N1 - Accession Number: 17810798; Hu, Yuan 1; Email Address: yhu@ora.fda.gov Hirshfield, Irvin 2; Affiliation: 1: U.S. Food and Drug Administration, Northeast Regional Laboratory, Microbiological Sciences Branch, 158-15 Liberty Avenue, Jamaica, NY 11433, USA 2: St. John's University, Jamaica, NY 11439, USA; Source Info: Jul2005, Vol. 127 Issue 1, p80; Subject Term: HEPATITIS C; Subject Term: HEPATITIS C virus; Subject Term: MESSENGER RNA; Subject Term: CIRCULAR DNA; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: cDNA; Author-Supplied Keyword: cDNA library; Author-Supplied Keyword: Long-PCR; Author-Supplied Keyword: mRNA; Author-Supplied Keyword: Mung bean nuclease; Author-Supplied Keyword: Nested-PCR; Author-Supplied Keyword: Subtraction hybridization; Author-Supplied Keyword: Unrecognized viral agents; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2005.02.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wei-Wei Chiu
AU - Kinney, Richard M.
AU - Dreher, Theo W.
T1 - Control of Translation by the 5′- and 3′-Terminal Regions of the Dengue Virus Genome.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/07//
VL - 79
IS - 13
M3 - Article
SP - 8303
EP - 8315
SN - 0022538X
AB - The genomic RNAs of flaviviruses such as dengue virus (DEN) have a 5′ m⁷GpppN cap like those of cellular mRNAs but lack a 3′ poly(A) tail. We have studied the contributions to translational expression of 5′- and 3′-terminal regions of the DEN serotype 2 genome by using luciferase reporter mRNAs transfected into Vero cells. DCLD RNA contained the entire DEN 5′ and 3′ untranslated regions (UTRs), as well as the first 36 codons of the capsid coding region fused to the luciferase reporter gene. Capped DCLD RNA was as efficiently translated in Vero cells as rapped GLGpA RNA, a reporter with UTRs from the highly expressed α-globin mRNA and a 72-residue poly(A) tail. Analogous reporter RNAs with regulatory sequences from West Nile and Sindbis viruses were also strongly expressed. Although capped DCLD RNA was expressed much more efficiently than its uncapped form, uncapped DCLD RNA was translated 6 to 12 times more efficiently than uncapped RNAs with UTRs from globin mRNA. The 5′ cap and DEN 3′ UTR were the main sources of the translational efficiency of DCLD RNA, and they acted synergistically in enhancing translation. The DEN 3′ UTR increased mRNA stability, although this effect was considerably weaker than the enhancement of translational efficiency. The DEN 3′ UTR thus has translational regulatory properties similar to those of a poly(A) tail. Its translation-enhancing effect was observed for RNAs with globin or DEN 5′ sequences, indicating no codependency between viral 5′ and 3′ sequences. Deletion studies showed that translational enhancement provided by the DEN 3′ UTR is attributable to the cumulative contributions of several conserved elements, as well as a nonconserved domain adjacent to the stop codon. One of the conserved elements was the conserved sequence (CS) CS1 that is complementary to cCS1 present in the 5′ end of the DEN polyprotein open reading frame. Complementarity between CS1 and cCS1 was not required for efficient translation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC translation
KW - DENGUE viruses
KW - VIRAL genomes
KW - FLAVIVIRUSES
KW - MESSENGER RNA
KW - VIROLOGY
KW - GENETIC code
KW - GENETIC regulation
N1 - Accession Number: 17542102; Wei-Wei Chiu 1 Kinney, Richard M. 2 Dreher, Theo W. 1,3; Email Address: theo.dreher@orst.edu; Affiliation: 1: Department of Microbiology, Oregon State University, Corvallis, Oregon 97331-3804 2: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US. Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522 3: Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331-3804; Source Info: Jul2005, Vol. 79 Issue 13, p8303; Subject Term: GENETIC translation; Subject Term: DENGUE viruses; Subject Term: VIRAL genomes; Subject Term: FLAVIVIRUSES; Subject Term: MESSENGER RNA; Subject Term: VIROLOGY; Subject Term: GENETIC code; Subject Term: GENETIC regulation; Number of Pages: 13p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.13.8303-8315.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beasley, David W. C.
AU - Whiteman, Melissa C.
AU - Shuliu Zhang
AU - Huang, Claire Y.-H.
AU - Schneider, Bradley S.
AU - Smith, Darci R.
AU - Gromowski, Gregory D.
AU - Higgs, Stephen
AU - Kinney, Richard M.
AU - Barrett, Alan D. T.
T1 - Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus Strains.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/07//
VL - 79
IS - 13
M3 - Article
SP - 8339
EP - 8347
SN - 0022538X
AB - The introduction of West Nile virus (WNV) into North America has been associated with relatively high rates of neurological disease and death in humans, birds, horses, and some other animals. Previous studies identified strains in both genetic lineage 1 and genetic lineage 2, including North American isolates of lineage 1, that were highly virulent in a mouse neuroinvasion model, while other strains were avirulent or significantly attenuated (D. W. C. Beasley, L. Li, M. T. Suderman, and A. D. T. Barrett, Virology 296:17–23, 2002). To begin to elucidate the basis for these differences, we compared a highly virulent New York 1999 (NY99) isolate with a related Old World lineage l strain, An4766 (ETH76a), which is attenuated for mouse neuroinvasion. Genomic sequencing of ETH76a revealed a relatively small number of nucleotide (5.1%) and amino acid (0.6%) differences compared with NY99. These differences were located throughout the genome and included five amino acid differences in the envelope protein gene. Substitution of premembrane and envelope genes of ETH76a into a NY99 infectious clone backbone yielded a virus with altered in vitro growth characteristics and a mouse virulence phenotype comparable to ETH76a. Further site-specific mutagenesis studies revealed that the altered phenotype was primarily mediated via loss of envelope protein glycosylation and that this was associated with altered stability of the virion at mildly acidic pH. Therefore, the enhanced virulence of North American WNV strains compared with other Old World lineage I strains is at least partly mediated by envelope protein glycosylation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEST Nile virus
KW - PHENOTYPE
KW - VIRULENCE (Microbiology)
KW - GLYCOSYLATION
KW - PROTEINS
KW - VIRAL genomes
KW - MUTAGENESIS
KW - NERVOUS system -- Diseases
KW - VIROLOGY
N1 - Accession Number: 17542105; Beasley, David W. C. 1; Email Address: d.beasley@utmb.edu Whiteman, Melissa C. 1 Shuliu Zhang 1 Huang, Claire Y.-H. 2 Schneider, Bradley S. 1 Smith, Darci R. 1 Gromowski, Gregory D. 1 Higgs, Stephen 1 Kinney, Richard M. 2 Barrett, Alan D. T. 1; Affiliation: 1: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 2: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US. Department of Health and Human Services, Fort Collins, Colorado; Source Info: Jul2005, Vol. 79 Issue 13, p8339; Subject Term: WEST Nile virus; Subject Term: PHENOTYPE; Subject Term: VIRULENCE (Microbiology); Subject Term: GLYCOSYLATION; Subject Term: PROTEINS; Subject Term: VIRAL genomes; Subject Term: MUTAGENESIS; Subject Term: NERVOUS system -- Diseases; Subject Term: VIROLOGY; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/JVI.79.13.8339-8347.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yong-Hak Kim
AU - Engesser, Karl-H.
AU - Cerniglia, Carl E.
T1 - Numerical and Genetic Analysis of Polycyclic Aromatic Hydrocarbon-Degrading Mycobacteria.
JO - Microbial Ecology
JF - Microbial Ecology
Y1 - 2005/07//
VL - 50
IS - 1
M3 - Article
SP - 110
EP - 119
SN - 00953628
AB - Ability to degrade high molecular weight polycyclic aromatic hydrocarbons (PAHs) has been found in diverse species of fast-growing mycobacteria. This study included several PAH-degrading mycobacteria from heavily contaminated sites and an uncontaminated humus soil in the Natural Park, Schwäbische Alb, Germany. The numerical analysis with a total of 131 tests showed that isolates from humus soil and contaminated sites had similar substrate utilization patterns for primary alcohols from ethanol to pentanol, 1,4-butanediol, benzyl alcohol, hexadecane, ethyl acetate, fluoranthene, phenanthrene, and pyrene as the sole carbon and energy (C/E) sources. Significant differences between the two subgroups isolated from humus soil and contaminated sites were observed in the utilization of polyalcoholic sugars, including adonitol, D-arabitol, L-arabitol, erythritol, inositol, rhamnose, sorbitol, and xylitol. Among isolates from humus soil, strain PYR100 showed high similarity in 16S rDNA sequence with M. vanbaalenii strain PYR-1 (=DSM 7251, 100%) and M. austroafricanum ATCC 33464 (99.9%). In addition to the numerical analysis, the 16S–23S intergenic spacer sequence was useful for discriminating between the closely related strains PYR100 and PYR-1 (98% similarity). The patterns of the variable V2 and V3 regions in the ribosomal RNA gene corresponding to Escherichia coli positions 179 to 197 and 1006 to 1023, respectively, were useful for dividing fast-growing and thermosensitive PAH-degrading mycobacteria into ten subgroups consistent with the phylogenetic positions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbial Ecology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCYCLIC aromatic hydrocarbons
KW - MOLECULAR weights
KW - MYCOBACTERIA
KW - SOIL pollution
KW - HUMUS
N1 - Accession Number: 18439167; Yong-Hak Kim 1,2; Email Address: yhkim660628@hotmail.com Engesser, Karl-H. 3 Cerniglia, Carl E. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079 2: School of Biological Sciences, Seoul National University, San 56-1 Shinrim-dong, Kwanak-ku, Seoul 151-747, Republic of Korea 3: Abteilung Biologische Abluftreinigung, Institut für Siedlungswasserbau, Wassergüteund Abfallwirtschaft (ISWA), Universität Stuttgart, Bandtäle 2, 70569 Stuttgart, Germany; Source Info: Jul2005, Vol. 50 Issue 1, p110; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: MOLECULAR weights; Subject Term: MYCOBACTERIA; Subject Term: SOIL pollution; Subject Term: HUMUS; Number of Pages: 10p; Illustrations: 4 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1007/s00248-004-0126-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18439167&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lindon, John C
AU - Nicholson, Jeremy K
AU - Holmes, Elaine
AU - Keun, Hector C
AU - Craig, Andrew
AU - Pearce, Jake T M
AU - Bruce, Stephen J
AU - Hardy, Nigel
AU - Sansone, Susanna-Assunta
AU - Antti, Henrik
AU - Jonsson, Par
AU - Daykin, Clare
AU - Navarange, Mahendra
AU - Beger, Richard D
AU - Verheij, Elwin R
AU - Amberg, Alexander
AU - Baunsgaard, Dorrit
AU - Cantor, Glenn H
AU - Lehman-McKeeman, Lois
AU - Earll, Mark
T1 - Summary recommendations for standardization and reporting of metabolic analyses.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2005/07//
VL - 23
IS - 7
M3 - Article
SP - 833
EP - 838
SN - 10870156
AB - The article focuses on summary recommendations for standardization and reporting of metabolic analyses. The Standard Metabolic Reporting Structures (SMRS) group is a collection of interested parties from academia, industry and the government that first came together in November 2003 to derive and recommend standards for conducting and reporting metabonomics and metabolomics studies. These multivariate metabolic analyses have diverse applications, including pre-clinical drug safety assessment, disease diagnosis, plant metabolite profiling and environmental science. For a particular algorithm used to derive a model, any specific parameters relevant to the algorithm and the particular implementation of algorithm used should be stated. Because biological research now relies on so many different technologies, various protocols, terms, definitions, methods and reporting structures have developed within sub-disciplines employing the various techniques.
KW - Plant products
KW - Standardization
KW - Biological research
KW - Algorithms
KW - Metabolic regulation
KW - Mass production
N1 - Accession Number: 17550729; Lindon, John C 1; Nicholson, Jeremy K 1; Holmes, Elaine 1; Keun, Hector C 1; Craig, Andrew 1; Pearce, Jake T M 1; Bruce, Stephen J 1; Hardy, Nigel 2; Sansone, Susanna-Assunta 3; Antti, Henrik 4; Jonsson, Par 4; Daykin, Clare 5; Navarange, Mahendra 6; Beger, Richard D 7; Verheij, Elwin R 8; Amberg, Alexander 9; Baunsgaard, Dorrit 10; Cantor, Glenn H 11; Lehman-McKeeman, Lois 11; Earll, Mark 12; Affiliations: 1: Biological Chemistry, Biomedical Sciences Division, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK.; 2: Department of Computer Science, University of Wales, Aberystwyth, SY23 3DB, UK.; 3: European Bioinformatics Institute, EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.; 4: Research Group for Chemometrics, University of Umeå, SE-901 87 Umeå, Sweden.; 5: Centre for Analytical Biosciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.; 6: MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.; 7: Center for Metabolomics, Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.; 8: TNO Pharma, Utrechtseweg 48, PO Box 360, 3700AJ Zeist, The Netherlands.; 9: Sanofi-Aventis, Drug Safety Evaluation, Mainzer Landstrasse 50, 65795 Hattersheim, Germany.; 10: NovoNordisk A/S, Novo Nordisk Park DK-2760 Måløv, Denmark.; 11: Bristol-Myers Squibb, PO Box 5400, Princeton, New Jersey 08543, USA.; 12: Umetrics UK Ltd., Woodside House, Woodside Road, Winkfield, Windsor, SL4 2DX, UK.; Issue Info: Jul2005, Vol. 23 Issue 7, p833; Thesaurus Term: Plant products; Subject Term: Standardization; Subject Term: Biological research; Subject Term: Algorithms; Subject Term: Metabolic regulation; Subject Term: Mass production; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1038/nbt0705-833
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Edghill-Smith, Yvette
AU - Golding, Hana
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Scott, Dorothy
AU - Bray, Mike
AU - Nalca, Aysegul
AU - Hooper, Jay W.
AU - Whitehouse, Chris A.
AU - Schmitz, Joern E.
AU - Reimann, Keith A.
AU - Franchini, Genoveffa
T1 - Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox virus.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2005/07//
VL - 11
IS - 7
M3 - Article
SP - 740
EP - 747
PB - Nature Publishing Group
SN - 10788956
AB - Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4+ or CD8+ T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax). [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - VACCINIA
KW - SMALLPOX
KW - B cells
KW - MONKEYPOX virus
N1 - Accession Number: 17601052; Edghill-Smith, Yvette 1 Golding, Hana 2 Manischewitz, Jody 2 King, Lisa R. 2 Scott, Dorothy 3 Bray, Mike 4 Nalca, Aysegul 5 Hooper, Jay W. 6 Whitehouse, Chris A. 6 Schmitz, Joern E. 7 Reimann, Keith A. 7 Franchini, Genoveffa 1; Email Address: franchig@mail.nih.gov; Affiliation: 1: Animal Models ߪ Retroviral Vaccines Section, National Cancer Institute, 41/D804, Bethesda, Maryland 20892, USA 2: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29/232, HFM-345, Bethesda, Maryland 20892, USA 3: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29/232, HFM-345, Bethesda, Maryland 20892, USA 4: Biodefense Clinical Research Branch, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA 5: Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, USA 6: Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA 7: Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE-113, 330 Brookline Avenue, Boston, Massachusetts 02215, USA; Source Info: Jul2005, Vol. 11 Issue 7, p740; Subject Term: VACCINATION; Subject Term: VACCINIA; Subject Term: SMALLPOX; Subject Term: B cells; Subject Term: MONKEYPOX virus; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1038/nm1261
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malli, Suzanne
T1 - Keep a close eye on vacuum-assisted wound closure.
JO - Nursing
JF - Nursing
Y1 - 2005/07//
VL - 35
IS - 7
M3 - Article
SP - 25
EP - 25
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - This article focuses on usage of negative-pressure wound therapy (NPWT) to promote healing. A noninvasive mechanical wound care therapy, NPWT assists in wound healing by applying controlled localized negative pressure to a wound's surface and margins. As specified in the device labeling, NPWT is applied to a special foam dressing packed in the wound cavity or over a flap or graft. Vacuum pressure helps remove fluids and infectious material from the wound, which encourages healing. If a patient is undergoing NPWT, he should be closely monitored for signs and symptoms of overt and occult bleeding.
KW - WOUND healing
KW - WOUNDS & injuries
KW - THERAPEUTICS
KW - PERMEABILITY
KW - HEMORRHAGE
KW - HEALING
N1 - Accession Number: 17392480; Malli, Suzanne 1; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health.; Source Info: Jul2005, Vol. 35 Issue 7, p25; Subject Term: WOUND healing; Subject Term: WOUNDS & injuries; Subject Term: THERAPEUTICS; Subject Term: PERMEABILITY; Subject Term: HEMORRHAGE; Subject Term: HEALING; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106496046
T1 - Device safety. Keep a close eye on vacuum-assisted wound closure.
AU - Malli S
Y1 - 2005/07//
N1 - Accession Number: 106496046. Language: English. Entry Date: 20050812. Revision Date: 20150820. Publication Type: Journal Article; brief item; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Suction -- Methods
KW - Surgical Wound Care
KW - Surgical Wound -- Nursing
KW - Foam Dressings
KW - Monitoring, Physiologic
KW - Nursing Assessment
KW - Postoperative Hemorrhage -- Prevention and Control
KW - Vacuum
KW - Wound Healing
SP - 25
EP - 25
JO - Nursing
JF - Nursing
JA - NURSING
VL - 35
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health
U2 - PMID: 15988191.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - SECOR, W. E.
T1 - Immunology of human schistosomiasis: off the beaten path.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2005/07//Jul/Aug2005
VL - 27
IS - 7/8
M3 - Article
SP - 309
EP - 316
PB - Wiley-Blackwell
SN - 01419838
AB - Reviews of the immunology of human schistosomiasis generally address the host's protective responses against infection or the factors associated with development of severe pathology. However, there is a growing recognition that the high number of patients expressing moderate morbidity, rather than the few patients with severe morbidity, accounts for the greatest public health impact of schistosomiasis. Therefore, other aspects of the host immune response that have received relatively little attention may actually provide pivotal answers in our understanding and management of the morbidity associated with human schistosomiasis. This review highlights lines of investigation that focus on how immune responses to schistosomiasis may affect schistosomiasis-associated anaemia, alter susceptibility or disease progression during co-infections, and influence effective execution of mass treatment programmes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasite Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHISTOSOMIASIS
KW - SCHISTOSOMA
KW - IMMUNE response
KW - ANEMIA
KW - PARASITIC diseases
KW - anaemia
KW - co-infection
KW - HIV
KW - immune response
KW - mass treatment
KW - schistosomiasis
N1 - Accession Number: 18096530; SECOR, W. E. 1; Email Address: was4@cdc.gov; Affiliation: 1: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, GA, USA; Source Info: Jul/Aug2005, Vol. 27 Issue 7/8, p309; Subject Term: SCHISTOSOMIASIS; Subject Term: SCHISTOSOMA; Subject Term: IMMUNE response; Subject Term: ANEMIA; Subject Term: PARASITIC diseases; Author-Supplied Keyword: anaemia; Author-Supplied Keyword: co-infection; Author-Supplied Keyword: HIV; Author-Supplied Keyword: immune response; Author-Supplied Keyword: mass treatment; Author-Supplied Keyword: schistosomiasis; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1365-3024.2005.00778.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ning, Baitang
AU - Nowell, Susan
AU - Sweeney, Carol
AU - Ambrosone, Christine B.
AU - Williams, Suzanne
AU - Miao, Xiaoping
AU - Liang, Gang
AU - Lin, Dongxin
AU - Stone, Angie
AU - Luke Ratnasinghe, D.
AU - Manjanatha, Mugimane
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Common genetic polymorphisms in the 5′-flanking Region of the SULT1A1 gene: haplotypes and their association with platelet enzymatic activity.
JO - Pharmacogenetics
JF - Pharmacogenetics
Y1 - 2005/07//
VL - 15
IS - 7
M3 - Article
SP - 465
EP - 473
SN - 0960314X
AB - SULT1A1 is a phase II detoxification enzyme involved in the biotransformation of a wide variety of endogenous and exogenous phenolic compounds. Human platelet SULT1A1 enzymatic activity shows marked inter-individual variability and a common coding polymorphism, SULT1A1∗1/∗2, has been described that accounts for a proportion of this variability. We examined the 5′-flanking region of the SULT1A1 gene to determine if genetic variability in this portion of the gene influenced enzymatic activity. Direct sequencing revealed five common genetic polymorphisms (-624G>C, -396G>A, -358A>C, -341C>G and -294T>C) that were present at different allele frequencies in Caucasian, African-American and Chinese groups. Platelet SULT1A1 enzymatic activity was significantly correlated with individual promoter region polymorphisms and the associations were different between African-Americans and Caucasians. Haplotypes were constructed and platelet enzymatic activity according to haplotype was examined. The haplotypes were also significantly correlated with activity; haplotypes GAACT and GGACT (accounting for 13% and 5% of inter-individual variability in platelet activity, respectively) were important in Caucasians while haplotypes GAACC, GAACT and GGACC (accounting for 8%, 5% and 4% of variability) were significantly associated with activity in African-Americans. The coding region polymorphism, SULT1A1∗1/∗2 was in linkage disequilibrium with the promoter region polymorphisms and showed no effect on activity when examined in the context of the 5′-flanking region polymorphisms. These studies indicate that variation in the promoter region of the SULT1A1 gene exerts a significant influence on enzymatic activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenetics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - activity
KW - genotype
KW - haplotype
KW - sulphotransferase
N1 - Accession Number: 115111991; Ning, Baitang 1 Nowell, Susan 1 Sweeney, Carol 1 Ambrosone, Christine B. 1 Williams, Suzanne 1 Miao, Xiaoping 1 Liang, Gang 1 Lin, Dongxin 1 Stone, Angie 1 Luke Ratnasinghe, D. 1 Manjanatha, Mugimane 1 Lang, Nicholas P. 1 Kadlubar, Fred F. 1; Affiliation: 1: Divisions of a Pharmacogenomics and Molecular Epidemiology b Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arizona, USA c Roswell Park Cancer Institute, Buffalo, New York, USA d University of Utah, Salt Lake City, Utah, USA e Central Arkansas Veteran's Health Care System, 11-LR, Little Rock, Arkansas, USA f Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China g Department of Surgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Source Info: Jul2005, Vol. 15 Issue 7, p465; Author-Supplied Keyword: activity; Author-Supplied Keyword: genotype; Author-Supplied Keyword: haplotype; Author-Supplied Keyword: sulphotransferase; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 6782
L3 - 10.1097/01.fpc.0000166823.74378.79
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=115111991&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frueh, F. W.
AU - Goodsaid, F.
AU - Rudman, A.
AU - Huang, S. -M.
AU - Lesko, L. J.
T1 - The need for education in pharmacogenomics: a regulatory perspective.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2005/07//
VL - 5
IS - 4
M3 - Article
SP - 218
EP - 220
PB - Nature Publishing Group
SN - 1470269X
AB - Talks about the role of regulatory agencies in providing education on pharmacogenomics. Purposes of the "Guidance for Industry: Pharmacogenomic Data Submissions," issued by the U.S. Food and Drug Administration (FDA); Missions of the FDA in protecting and advancing public health; Examples of drugs with labels that contain information on pharmacogenomics.
KW - PHARMACOGENOMICS
KW - EDUCATION
KW - PUBLIC health
KW - DRUGS
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 17715727; Frueh, F. W. 1 Goodsaid, F. 1 Rudman, A. 1 Huang, S. -M. 1 Lesko, L. J. 1; Affiliation: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Clinical Pharmacology and Biopharmaceutics, 1451 Rockville Pike, HFD-860, Room 2040, Rockville, MD 20852, USA; Source Info: 2005, Vol. 5 Issue 4, p218; Subject Term: PHARMACOGENOMICS; Subject Term: EDUCATION; Subject Term: PUBLIC health; Subject Term: DRUGS; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
L3 - 10.1038/sj.tpj.6500316
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McComas, Katherine A.
AU - Tuite, Leah Simone
AU - Sherman, Linda Ann
T1 - Conflicted scientists: the “shared pool” dilemma of scientific advisory committees.
JO - Public Understanding of Science
JF - Public Understanding of Science
Y1 - 2005/07//
VL - 14
IS - 3
M3 - Article
SP - 285
EP - 303
SN - 09636625
AB - Examines the term "shared pool" dilemma using data collected from a number of members in 11 U.S. Food and Drug Administration (FDA) advisory committees. Role of science advisors in government policy making; Infestation of allegations of conflict on advisory committee despite efforts to manage conflict of interest among science advisors; Association of the neutrality of the process to the success of the FDA's conflict of interest.
KW - CONFLICT of interests
KW - SCIENCE consultants
KW - CONSULTANTS
KW - SCIENTISTS
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 17759208; McComas, Katherine A. 1; Email Address: kam19@cornell.edu; Tuite, Leah Simone 2; Sherman, Linda Ann 3; Affiliations: 1 : Department of Communication, Cornell University, 313 Kennedy Hall, Ithaca, New York 14853, USA; 2 : Department of Communication, University of Maryland; 3 : US Food and Drug Administration, Rockville, MD; Source Info: Jul2005, Vol. 14 Issue 3, p285; Subject Term: CONFLICT of interests; Subject Term: SCIENCE consultants; Subject Term: CONSULTANTS; Subject Term: SCIENTISTS; Subject: UNITED States; Number of Pages: 19p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - 24h
ER -
TY - JOUR
AU - Anderson, Jeri L.
AU - Hertel, Nolan E.
T1 - BREMSSTRAHLUNG DOSES FROM NATURAL URANIUM INGOTS.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2005/07//
VL - 115
IS - 1-4
M3 - Article
SP - 298
EP - 301
SN - 01448420
AB - In the past, some privately owned commercial facilities in the United States were involved in producing or processing radioactive materials used in the production of atomic weapons. Seven different geometrical objects, representative of the configurations of natural uranium metal potentially encountered by workers at these facilities, are modelled to determine gamma ray and bremsstrahlung dose rates. The dose rates are calculated using the MCNP5 code and also by using the MICROSHIELD point-kernel code. Both gamma ray and bremsstrahlung dose rates are calculated and combined to obtain a total dose rate. The two methods were found to be in good agreement despite differences in modelling assumptions and method differences. Computed total dose rates on the surface of these objects ranged from ∼51-84 μSv h-1 and 17-95 μSv h-1 using the MCNP5 and the MICROSHIELD modeling, respectively. The partitioning of the computed dose rates between gamma rays and bremsstrahlung were the same order of magnitude for each object. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nuclear reactions
KW - Ionizing radiation
KW - Nuclear weapons
KW - Radioactive substances
KW - Electromagnetic waves
KW - Gamma rays
N1 - Accession Number: 20074190; Anderson, Jeri L. 1; Email Address: JLAnderson@cdc.gov; Hertel, Nolan E. 2; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.; 2: G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA.; Issue Info: 2005, Vol. 115 Issue 1-4, p298; Thesaurus Term: Nuclear reactions; Thesaurus Term: Ionizing radiation; Thesaurus Term: Nuclear weapons; Thesaurus Term: Radioactive substances; Subject Term: Electromagnetic waves; Subject Term: Gamma rays; Number of Pages: 4p; Document Type: Article
L3 - 10.1093/rpd/nci119
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Perrin-Guyomard, Agnes
AU - Poul, Jean-Michel
AU - Corpet, Denis E.
AU - Sanders, Pascal
AU - Fernández, A. Haydée
AU - Bartholomew, Mary
T1 - Impact of residual and therapeutic doses of ciprofloxacin in the human-flora-associated mice model
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/07//
VL - 42
IS - 2
M3 - Article
SP - 151
EP - 160
SN - 02732300
AB - Abstract: A study was conducted to evaluate the effects of therapeutic and residual doses of ciprofloxacin on the human intestinal flora implanted into germ-free mice. Ciprofloxacin was administered daily via drinking water at concentrations to provide doses of 0, 0.125, 1.25, and 12.5mg/kg b.w. Changes in the intestinal flora composition, alteration in bacterial enzyme activities, fecal short chain fatty acid concentration and bacterial cellular fatty acid profiles, overgrowth of resistant bacteria, and disruption of the colonization barrier were the endpoints evaluated in the feces of human-flora-associated (HFA) mice. Ciprofloxacin at all tested doses decreased significantly the aerobic populations and particularly the population of Enterobacteriaceae. Selection of resistant Bacteroides fragilis group was noticed in HFA mice receiving 12.5mg/kg b.w. In mice challenged with a Salmonella strain, exogenous Salmonella persisted in the feces of all treated mice indicating that the flora responsible for the colonization barrier effect was disturbed by the antibiotic treatment. None of the studied metabolic parameters of the flora were affected by ciprofloxacin at any dose level. Under the experimental conditions of the study, the no-observed-effect level of ciprofloxacin was found to be less than 0.125mg/kg b.w. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterobacteriaceae
KW - Fatty acids
KW - Salmonella
KW - Ciprofloxacin
KW - Veterinary drugs
KW - Human-flora-associated mouse model
KW - Intestinal flora
KW - Veterinary drug residues
N1 - Accession Number: 18007620; Perrin-Guyomard, Agnes 1; Email Address: a.perrin-guyomard@afssa.fr; Poul, Jean-Michel 1; Corpet, Denis E. 2; Sanders, Pascal 1; Fernández, A. Haydée 3; Bartholomew, Mary 3; Affiliations: 1: Agence Française de Sécurité Sanitaire des Aliments, Laboratoire d’études et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougères cedex, France; 2: Ecole Nationale Vétérinaire, INRA, Laboratoire de Sécurité des Aliments, 31076 Toulouse, France; 3: United States Food and Drug Administration—Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Jul2005, Vol. 42 Issue 2, p151; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Fatty acids; Thesaurus Term: Salmonella; Subject Term: Ciprofloxacin; Subject Term: Veterinary drugs; Author-Supplied Keyword: Human-flora-associated mouse model; Author-Supplied Keyword: Intestinal flora; Author-Supplied Keyword: Veterinary drug residues; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.03.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pohl, Hana R.
AU - Luukinen, Bryan
AU - Holler, James S.
T1 - Health effects classification and its role in the derivation of minimal risk levels: Reproductive and endocrine effects
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/07//
VL - 42
IS - 2
M3 - Article
SP - 209
EP - 217
SN - 02732300
AB - Abstract: The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. From the total of 326 MRLs currently posted on ATSDR’s web site (www.atsdr.cdc.gov), 14 and 5 MRLs are based on reproductive and endocrine endpoints, respectively. The paper also describes the ranking of effects into less serious and serious categories according to ATSDR’s Guidance for Developing Toxicological Profiles, endpoints used for the MRLs derivation, and the use of uncertainty factors. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Hormones
KW - Endocrinology
KW - Internal medicine
KW - Health guidance values
KW - MRL
KW - Reproductive effects
KW - RfC
KW - RfD
N1 - Accession Number: 18007626; Pohl, Hana R. 1; Email Address: hpohl@cdc.gov; Luukinen, Bryan 2; Holler, James S. 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA; 2: Internship Fellow Oak Ridge Institute for Science and Education, US Department of Energy, Oak Ridge, TN, USA; Issue Info: Jul2005, Vol. 42 Issue 2, p209; Thesaurus Term: Toxicology; Thesaurus Term: Hormones; Subject Term: Endocrinology; Subject Term: Internal medicine; Author-Supplied Keyword: Health guidance values; Author-Supplied Keyword: MRL; Author-Supplied Keyword: Reproductive effects; Author-Supplied Keyword: RfC; Author-Supplied Keyword: RfD; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.04.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bailey, Allan B.
AU - Chanderbhan, Ronald
AU - Collazo-Braier, Nancy
AU - Cheeseman, M.A.
AU - Twaroski, Michelle L.
T1 - The use of structure–activity relationship analysis in the food contact notification program
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/07//
VL - 42
IS - 2
M3 - Article
SP - 225
EP - 235
SN - 02732300
AB - Abstract: Food contact substances (FCS) include polymers, paper and paperboard, and substances used in their manufacture, that do not impart a technical effect on food. Moreover, FCSs are industrial chemicals generally consumed at dietary concentrations (DC) of less than 1mg/kg food (ppm), and more commonly at less than 0.05ppm (50ppb), in the daily diet. As such, many industrial chemicals have been analyzed for toxicological concern, some of which may share structural similarity with FCSs or their constituents, and the majority of these studies are available in the public domain. The DCs of these compounds lend themselves to using structure–activity relationship (SAR) analysis, as the available “expert systems” and use of analogs allows for prediction and management of potential carcinogens. This paper describes the newly implemented food contact notification (FCN) program, the program by which FDA reviews FCSs for safe use, the administrative review of FCSs, the SAR tools available to FDA, and qualitative and quantitative risk assessments using SAR analysis within the regulatory framework of reviewing the safety of FCSs. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Food consumption
KW - Food contamination
KW - Paper chemicals
KW - Food and drug administration
KW - Food contact notification
KW - Food contact substances
KW - MCASE
KW - Mutagenicity
KW - OnocoLogic
KW - Structure alerts
KW - Structure–activity relationship
KW - TD50
KW - Threshold of regulation
N1 - Accession Number: 18007628; Bailey, Allan B. 1; Chanderbhan, Ronald 1; Collazo-Braier, Nancy; Cheeseman, M.A. 1; Twaroski, Michelle L.; Email Address: Michelle.Twaroski@cfsan.fda.gov; Affiliations: 1: Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA; Issue Info: Jul2005, Vol. 42 Issue 2, p225; Thesaurus Term: Hazardous substances; Thesaurus Term: Food consumption; Thesaurus Term: Food contamination; Thesaurus Term: Paper chemicals; Author-Supplied Keyword: Food and drug administration; Author-Supplied Keyword: Food contact notification; Author-Supplied Keyword: Food contact substances; Author-Supplied Keyword: MCASE; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: OnocoLogic; Author-Supplied Keyword: Structure alerts; Author-Supplied Keyword: Structure–activity relationship; Author-Supplied Keyword: TD50; Author-Supplied Keyword: Threshold of regulation; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.04.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leiyu Shi
AU - Macinko, James
AU - Starfield, Barbara
AU - Politzer, Robert
AU - Jiahong Xu
T1 - Primary care, race, and mortality in US states.
JO - Social Science & Medicine
JF - Social Science & Medicine
Y1 - 2005/07//
VL - 61
IS - 1
M3 - Article
SP - 65
EP - 75
SN - 02779536
AB - This study used US state-level data from 1985 to 1995 to examine the relationship of primary care resources and income inequality with all-cause mortality within the entire population, and in black and white populations. The study is a pooled ecological design with repeated measures using 11 years of state-level data (n = 549). Analyses controlled for socioeconomic and demographic characteristics. Contemporaneous and time-lagged covariates were modeled, and all analyses were stratified by race/ethnicity. In all models, primary care was associated with lower mortality. An increase of one primary care doctor per 10,000 population was associated with a reduction of 14.4 deaths per 100,000. The magnitude of primary care coefficients was higher for black mortality than for white mortality. Income inequality was not associated with mortality after controlling for state-level sociodemographic covariates. The study provides evidence that primary care resources are associated with population health and could aid in reducing socioeconomic disparities in health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Science & Medicine is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY care (Medicine)
KW - MORTALITY
KW - INCOME distribution
KW - ETHNIC groups
KW - PUBLIC health -- United States
KW - UNITED States
KW - Ethnicity.
KW - Mortality
KW - Primary care resources
KW - USA
N1 - Accession Number: 16965078; Leiyu Shi 1; Email Address: lshi@jhsph.edu Macinko, James 2 Starfield, Barbara 1 Politzer, Robert 3 Jiahong Xu 1; Affiliation: 1: Department of Health Policy and Management, Johns Hopkins School of Public Health & Hygiene, 624 North Broadway, Room 409, Baltimore, MD 21205-1996, USA. 2: Department of Nutrition, Food Studies and Public Health, New York University Steinhardt School of Education, New York, NY, USA. 3: Bureau of Primary Health Care, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, MD, USA.; Source Info: Jul2005, Vol. 61 Issue 1, p65; Subject Term: PRIMARY care (Medicine); Subject Term: MORTALITY; Subject Term: INCOME distribution; Subject Term: ETHNIC groups; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Ethnicity.; Author-Supplied Keyword: Mortality; Author-Supplied Keyword: Primary care resources; Author-Supplied Keyword: USA; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.socscimed.2004.11.056
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Akiba, Jun
AU - Umemura, Takeji
AU - Alter, Harvey J.
AU - Kojiro, Masamichi
AU - Tabor, Edward
T1 - SEN virus: epidemiology and characteristics of a transfusion-transmitted virus.
JO - Transfusion
JF - Transfusion
Y1 - 2005/07//
VL - 45
IS - 7
M3 - Article
SP - 1084
EP - 1088
PB - Wiley-Blackwell
SN - 00411132
AB - SEN virus (SEN-V) is a blood-borne, single-stranded, nonenveloped DNA virus. Although its prevalence varies by geographic region, it has been detected in as many as 30 percent of postoperative transfusion recipients, compared to 3 percent of postoperative patients who did not receive transfusions. A significant association has been observed between transfusion volume and the occurrence of SEN-V infection. Transmission by transfusion also has been confirmed by the detection of greater than 99 percent homology between SEN-V in donor and recipient sera. Concurrent infections with SEN-V and hepatitis B virus, hepatitis C virus, or human immunodeficiency virus type 1 have been documented, and these observations probably reflect the blood-borne transmission of these viruses as well as SEN-V. Although SEN-V was discovered as part of a search for causes of posttransfusion hepatitis, there is no firm evidence so far that SEN-V infection either causes hepatitis or worsens the course of coexistent liver disease. Nevertheless, SEN-V appears to be transmitted by transfusion, and further studies may reveal more about its role in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - DNA viruses
KW - BLOOD transfusion
KW - HEPATITIS B virus
KW - HEPATITIS C virus
KW - HIV (Viruses)
N1 - Accession Number: 17412018; Akiba, Jun 1,2,3 Umemura, Takeji 1,2,3 Alter, Harvey J. 1,2,3 Kojiro, Masamichi 1,2,3 Tabor, Edward 1,2,3; Email Address: tabor@cber.fda.gov; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesdal, Maryland. 2: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland. 3: Department of Pathology, Kurume University School of Medicine, Kurume, Japan.; Source Info: Jul2005, Vol. 45 Issue 7, p1084; Subject Term: VIRUSES; Subject Term: DNA viruses; Subject Term: BLOOD transfusion; Subject Term: HEPATITIS B virus; Subject Term: HEPATITIS C virus; Subject Term: HIV (Viruses); Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1537-2995.2004.00209.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17412018&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106426139
T1 - SEN virus: epidemiology and characteristics of a transfusion-transmitted virus.
AU - Akiba J
AU - Umemura T
AU - Alter HJ
AU - Kojiro M
AU - Tabor E
Y1 - 2005/07//
N1 - Accession Number: 106426139. Language: English. Entry Date: 20060414. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Blood Transfusion -- Adverse Effects
KW - DNA Virus Infections -- Transmission
KW - DNA Virus Infections -- Epidemiology
KW - Prevalence
KW - Immunoenzyme Techniques -- Methods
KW - Epidemiological Research
KW - Human
SP - 1084
EP - 1088
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 45
IS - 7
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - SEN virus (SEN-V) is a blood-borne, single-stranded, nonenveloped DNA virus. Although its prevalence varies by geographic region, it has been detected in as many as 30 percent of postoperative transfusion recipients, compared to 3 percent of postoperative patients who did not receive transfusions. A significant association has been observed between transfusion volume and the occurrence of SEN-V infection. Transmission by transfusion also has been confirmed by the detection of greater than 99 percent homology between SEN-V in donor and recipient sera. Concurrent infections with SEN-V and hepatitis B virus, hepatitis C virus, or human immunodeficiency virus type 1 have been documented, and these observations probably reflect the blood-borne transmission of these viruses as well as SEN-V. Although SEN-V was discovered as part of a search for causes of posttransfusion hepatitis, there is no firm evidence so far that SEN-V infection either causes hepatitis or worsens the course of coexistent liver disease. Nevertheless, SEN-V appears to be transmitted by transfusion, and further studies may reveal more about its role in the future.
SN - 0041-1132
AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD
U2 - PMID: 15987351.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106426139&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mossoba, Magdi M.
AU - Al-Khaldi, Sufian F.
AU - Kirkwood, Jonah
AU - Fry, Frederick S.
AU - Sedman, Jacqueline
AU - Ismail, Ashraf A.
T1 - Printing microarrays of bacteria for identification by infrared microspectroscopy
JO - Vibrational Spectroscopy
JF - Vibrational Spectroscopy
Y1 - 2005/07//
VL - 38
IS - 1/2
M3 - Article
SP - 229
EP - 235
SN - 09242031
AB - Abstract: Fourier transform infrared (FTIR) spectroscopy has been established as a rapid bacteria identification technique. To increase the throughput of this methodology, the feasibility of applying contact deposition microarray technology to print intact bacterial cells as arrayed deposits (150μm diameter) on optical substrates and on agar slides was demonstrated for the first time. This contact deposition technology delivers nanoliter (nL) droplets of bacterial suspensions from a microtiter plate onto a slide surface. Protocols for printing microarrays of whole-cells on agar and on infrared (IR)-transparent slides were evaluated and optimized for subsequent measurement by IR microspectroscopy and IR imaging. Parameters that were investigated included pin capacity, deposition mode, and spatial distribution of microarrays. Bacteria representing eight genera (Yersinia, Staphylococcus, Salmonella, Listeria, Enterobacter, Citrobacter, Klebsiella, and Escherichia) were used in this proof-of-concept study. The resulting dendrograms generated by hierarchical cluster analysis (HCA) demonstrated clustering of the descendants of the foodborne bacteria investigated into their respective branches. The suitability of microarray printing coupled to focal-plane-array (FPA) FTIR detection for the rapid identification of bacteria was demonstrated. [Copyright &y& Elsevier]
AB - Copyright of Vibrational Spectroscopy is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - PROKARYOTES
KW - FUNGUS-bacterium relationships
KW - POLYSACCHARIDES
KW - Bacteria identification
KW - Food safety
KW - FPA-FTIR
KW - Imaging
KW - Infrared
KW - Microarray
N1 - Accession Number: 18141866; Mossoba, Magdi M. 1; Email Address: magdi.mossoba@fda.hhs.gov Al-Khaldi, Sufian F. 2 Kirkwood, Jonah 3 Fry, Frederick S. 1 Sedman, Jacqueline 3 Ismail, Ashraf A. 3; Affiliation: 1: Division of General Scientific Support, OSAS, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 2: Division of Microbiological Studies, OPDFB, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 3: McGill IR Group, Department of Food Science and Agricultural Chemistry, McGill University, Montreal, Que., Canada H9X 3V9; Source Info: Jul2005, Vol. 38 Issue 1/2, p229; Subject Term: ENTEROBACTERIACEAE; Subject Term: PROKARYOTES; Subject Term: FUNGUS-bacterium relationships; Subject Term: POLYSACCHARIDES; Author-Supplied Keyword: Bacteria identification; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: FPA-FTIR; Author-Supplied Keyword: Imaging; Author-Supplied Keyword: Infrared; Author-Supplied Keyword: Microarray; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vibspec.2005.04.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18141866&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-06314-001
AN - 2006-06314-001
AU - Fisher, Nirah
AU - Amitai, Yona
AU - Haringman, Miri
AU - Meiraz, Hana
AU - Baram, Nira
AU - Leventhal, Alex
T1 - The prevalence of smoking among pregnant and postpartum women in Israel: A national survey and review.
JF - Health Policy
JO - Health Policy
JA - Health Policy
Y1 - 2005/07//
VL - 73
IS - 1
SP - 1
EP - 9
CY - Netherlands
PB - Elsevier Science
SN - 0168-8510
SN - 1872-6054
AD - Fisher, Nirah, Department of Mother, Child and Adolescent Health, Ministry of Health, 20 King David Street, Jerusalem, Israel, 91010
N1 - Accession Number: 2006-06314-001. PMID: 15911052 Partial author list: First Author & Affiliation: Fisher, Nirah; Department of Mother, Child and Adolescent Health, Ministry of Health, Jerusalem, Israel. Release Date: 20061211. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Jews; Perinatal Period; Pregnancy; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Epidemiology; Health; Human Females; Public Health Services; Risk Factors. Classification: Drug & Alcohol Usage (Legal) (2990); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Location: Israel. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2005.
AB - Background: Cigarette smoking during pregnancy is a significant health risk to the developing fetus. In order to develop and implement an appropriate preconceptional and prenatal smoking cessation program a national pregnancy risk survey was done. Methods: The survey was conducted through the Public Health Service's, Mother and Child Health Clinics (MCHC). The nursing staff initiated structured interviews with pregnant women and mothers of newborn infants. Questions included in the survey addressed folic acid utilization, smoking habits, onset of prenatal care and demographic characteristics. Results: Overall, of the 1613 questionnaires received with smoking data, 12.8% of the women had smoked either in the 3 months preceding their current pregnancy and/or during their pregnancy. The smoking prevalence in Jewish women, was significantly greater then that found among Arab women (17.2 and 3.0%, p < .001, OR = 7.5, CI = 4.2-13.4). The prevalence of smoking for the duration of the pregnancy was 8.0% among Jewish women and 1.8% among Arab women. Among Jewish women, smoking prevalence was significantly associated with education, women who had completed 12 years of education were more likely to be nonsmokers (P = .034, OR = 1.8, CI = 1.0-3). Conclusion: Smoking in the preconceptional and prenatal period is a significant problem among Jewish women. Since fewer years of education is a significant risk factor, smoking cessation programs should focus on this subgroup of Jewish women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking
KW - pregnant women
KW - postpartum women
KW - Israel
KW - risk factor
KW - public health services
KW - smoking cessation
KW - prenatal period
KW - health
KW - Jewish women
KW - 2005
KW - Jews
KW - Perinatal Period
KW - Pregnancy
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Epidemiology
KW - Health
KW - Human Females
KW - Public Health Services
KW - Risk Factors
KW - 2005
DO - 10.1016/j.healthpol.2004.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06314-001&site=ehost-live&scope=site
UR - nirah.fisher@moh.health.gov.il
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07433-004
AN - 2005-07433-004
AU - Powers, John H.
AU - Cooper, Charles K.
AU - Lin, Daphne
AU - Ross, David B.
T1 - Sample size and the ethics of non-inferiority trials.
JF - The Lancet
JO - The Lancet
JA - Lancet
Y1 - 2005/07//
VL - 365
IS - 9479
SP - 24
EP - 25
CY - United Kingdom
PB - Lancet
SN - 0140-6736
SN - 1474-547X
AD - Powers, John H., Office of Drug Evaluation VI (DBR), Center for Drug Evaluation and Research, US Food and Drug Administration, 9201 Corporate Boulevard, HFD-104, Rockville, MD, US, 20850
N1 - Accession Number: 2005-07433-004. Partial author list: First Author & Affiliation: Powers, John H.; Center for Drug Evaluation and Research, US Food and Drug Administration, Office of Drug Evaluation IV, Rockville, MD, US. Release Date: 20050725. Correction Date: 20150413. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Clinical Trials; Experimentation; Sample Size. Minor Descriptor: Experimental Ethics; Methodology. Classification: Research Methods & Experimental Design (2260). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul, 2005.
AB - Comments on article by K. Schulz and D. Grimes (see record [rid]2005-03809-002[/rid]) on sample size and the ethics of non-inferiority clinical trials. The authors of this comment argue that Schulz and Grimes propose that it is ethical to enroll patients in 'underpowered' trials given the uncertainty involved in estimating sample size. However, it seems that this principle is most applicable to superiority trials. The uncertainty about treatment effects should be less when planning sample sizes for non-inferiority trials. Non-inferiority trials are designed to show that one intervention is no worse than another by some specific amount (the non-inferiority margin). Discussions among investigators and institutional review boards over whether placebo-controlled trials in self-resolving infectious diseases are ethical should also question the ethics of exposing patients to the potential risks of experimental treatments in noninferiority trials designed with inappropriately large margins that may not ensure that the effectiveness of a study intervention is greater than placebo. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sample size calculations
KW - clinical research
KW - randomized trials
KW - methodology
KW - ethics
KW - 2005
KW - Clinical Trials
KW - Experimentation
KW - Sample Size
KW - Experimental Ethics
KW - Methodology
KW - 2005
DO - 10.1016/S0140-6736(05)66817-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07433-004&site=ehost-live&scope=site
UR - POWERSJOH@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07657-004
AN - 2005-07657-004
AU - Bray, Jeremy W.
AU - Davis, Keith L.
AU - Graver, Linda
AU - Schroeder, Don
AU - Buck, Jeffrey A.
AU - Dilonardo, Joan
AU - Vandivort, Rita
T1 - Mental Health and Substance Abuse Treatment Utilization Among Individuals Served by Multiple Public Agencies in 3 States.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2005/07//Jul-Sep, 2005
VL - 32
IS - 3
SP - 282
EP - 293
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Bray, Jeremy W., Behavioral Health Economics Program, RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC, US, 27709
N1 - Accession Number: 2005-07657-004. PMID: 16010184 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Bray, Jeremy W.; Behavioral Health Economics Program, RTI International, Research Triangle Park, NC, US. Other Publishers: Springer. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Health Care Utilization; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jul-Sep, 2005.
AB - Patterns of mental health (MH) and substance abuse (SA) treatment utilization among populations receiving services through multiple public programs are not well known. This study examines to what extent populations with MH and/or SA conditions utilize treatment services through Medicaid and State MH/SA Agencies. Data are from the Substance Abuse and Mental Health Services Administration Integrated Database, a multiyear file for 3 states combining Medicaid and State MH/SA Agency administrative data into a uniform database. Although populations with co-occurring conditions and those served by both Medicaid and State MH/SA Agencies have substantial contact with the public treatment system, a majority of the MH/SA populations examined here utilize few services over brief periods of time. Utilization is most limited among individuals with MH-only conditions and those served exclusively by Medicaid. While a lack of data on clinical outcomes prevents us from drawing conclusions about the effectiveness of MH/SA services, results of this analysis indicate that public programs in the states examined here do not provide services that are primarily utilized on a frequent or chronic basis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health treatment
KW - substance abuse treatment
KW - treatment utilization
KW - public health services
KW - 2005
KW - Drug Rehabilitation
KW - Health Care Utilization
KW - Mental Health Services
KW - 2005
DO - 10.1007/BF02291828
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07657-004&site=ehost-live&scope=site
UR - bray@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07666-003
AN - 2005-07666-003
AU - Derzon, James H.
AU - Sale, Elizabeth
AU - Springer, J. Fred
AU - Brounstein, Paul
T1 - Estimating Intervention Effectiveness: Synthetic Projection of Field Evaluation Results.
JF - The Journal of Primary Prevention
JO - The Journal of Primary Prevention
JA - J Prim Prev
Y1 - 2005/07//
VL - 26
IS - 4
SP - 321
EP - 343
CY - Germany
PB - Springer
SN - 0278-095X
SN - 1573-6547
AD - Sale, Elizabeth, Missouri Institute of Mental Health, 5400 Arsenal Street, St. Louis, MO, US, 63139
N1 - Accession Number: 2005-07666-003. PMID: 15995802 Partial author list: First Author & Affiliation: Derzon, James H.; Pacific Institute for Research and Evaluation, Berkeley, CA, US. Release Date: 20051205. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Drug Abuse Prevention; Intervention; Program Evaluation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: Jul, 2005.
AB - In a 46-site, 5-year high-risk youth substance abuse prevention evaluation, effect sizes were adjusted using a meta-analytic regression technique to project potential effectiveness under more optimal research and implementation conditions. Adjusting effect size estimates to control for the impact of comparison group prevention exposure, service intensity, and coherent program implementation raised the mean effectiveness estimate from near zero (.02, SD = .21) to .24 (SD = .18). This finding suggests that adolescent prevention programs can have significant positive effects under optimal, yet obtainable conditions. Editors' Strategic Implications: The authors present a meta-analytic technique that promises to be an important tool for understanding what works in multi-site community-based prevention settings. Researchers will find this to be a creative approach to model the 'noise' in implementation that may often overshadow the potential impact of prevention programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intervention effectiveness
KW - at risk population
KW - substance abuse prevention
KW - adolescent prevention programs
KW - program effectiveness
KW - meta analysis
KW - 2005
KW - At Risk Populations
KW - Drug Abuse Prevention
KW - Intervention
KW - Program Evaluation
KW - 2005
DO - 10.1007/s10935-005-5391-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07666-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-3997-1950
UR - liz.sale@mimh.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06764-001
AN - 2005-06764-001
AU - Gatz, Margaret
AU - Brounstein, Paul
AU - Taylor, Jane
T1 - Serving the Needs of Women With Co-Occurring Disorders and a History of Trauma: Special Issue Introduction.
T3 - Serving the Needs of Women With Co-Occurring Disorders and a History of Trauma
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2005/07//
VL - 33
IS - 4
SP - 373
EP - 378
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Gatz, Margaret, Department of Psychology, University of Southern California, Los Angeles, CA, US, 90089-1061
N1 - Accession Number: 2005-06764-001. Partial author list: First Author & Affiliation: Gatz, Margaret; University of Southern California, Los Angeles, CA, US. Release Date: 20050705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Emotional Trauma; Mental Disorders; Mental Health Services. Minor Descriptor: Health Care Delivery; Health Service Needs. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). References Available: Y. Page Count: 6. Issue Publication Date: Jul, 2005.
AB - As a result of the fractionalization of the mental health and substance abuse treatment systems, as well as society's historically consistent antipathy about dealing with violence committed against women, women with co-occurring substance abuse and mental health disorders who have experienced physical or sexual abuse have not been well treated by existing service delivery systems. In this special issue, the articles lay out the rationale and theoretical foundations for intervention with this population, describe the population, discuss conceptual and pragmatic considerations in implementing the intervention, explore special concerns and compromises in designing the evaluation, and provide a voice for the women who had experienced these human traumas--the consumer/survivor/recoverer (C/S/R) women and the important contributions they made to this effort. Thus, the issue includes perspectives from all of the relevant stakeholders: the federal government, treatment program directors, researchers, clinicians, and C/S/R women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - traumatized women
KW - substance abuse
KW - co-occurring mental disorders
KW - health service needs
KW - health service delivery
KW - 2005
KW - Comorbidity
KW - Drug Abuse
KW - Emotional Trauma
KW - Mental Disorders
KW - Mental Health Services
KW - Health Care Delivery
KW - Health Service Needs
KW - 2005
DO - 10.1002/jcop.20057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06764-001&site=ehost-live&scope=site
UR - gatz@usc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06764-002
AN - 2005-06764-002
AU - Salasin, Susan E.
T1 - Evolution of Women's Trauma-Integrated Services at the Substance Abuse and Mental Health Services Administration.
T3 - Serving the Needs of Women With Co-Occurring Disorders and a History of Trauma
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2005/07//
VL - 33
IS - 4
SP - 379
EP - 393
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Salasin, Susan E., CMHS, SAMHSA, Room 11C-26, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2005-06764-002. Partial author list: First Author & Affiliation: Salasin, Susan E.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20050705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Emotional Trauma; Integrated Services; Health Care Policy. Minor Descriptor: Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). References Available: Y. Page Count: 15. Issue Publication Date: Jul, 2005.
AB - In this article a historical overview of the evolution of the Women's Trauma Integrated Services model at the Substance Abuse and Mental Health Services Administration (SAMHSA) is presented. Milestones in women's services policy development at SAMHSA (1992-1998) and in trauma treatment development for four different trauma populations (1960-1998) are discussed. SAMHSA's 5-year Women, Co-Occurring Disorders and Violence Study (1998-2003) is described, and the rationales for a number of basic decisions about the study design are presented. New knowledge application initiatives and plans at SAMHSA to further develop the Women's Trauma Integrated Services Model are outlined. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trauma integrated services
KW - Substance Abuse and Mental Health Services Administration
KW - health service policy
KW - 2005
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Emotional Trauma
KW - Integrated Services
KW - Health Care Policy
KW - Mental Health Services
KW - 2005
DO - 10.1002/jcop.20058
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06764-002&site=ehost-live&scope=site
UR - susan.salasin@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06764-006
AN - 2005-06764-006
AU - VanDeMark, Nancy R.
AU - Russell, Lisa A.
AU - O'Keefe, Maura
AU - Finkelstein, Norma
AU - Noether, Chanson D.
AU - Gampel, Joanne C.
T1 - Children of Mothers With Histories of Substance Abuse, Mental Illness, and Trauma.
T3 - Serving the Needs of Women With Co-Occurring Disorders and a History of Trauma
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2005/07//
VL - 33
IS - 4
SP - 445
EP - 459
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - VanDeMark, Nancy R., Arapahoe House, Inc., 8801 Lipan Street, Thornton, CO, US, 80260-4912
N1 - Accession Number: 2005-06764-006. Partial author list: First Author & Affiliation: VanDeMark, Nancy R.; Arapahoe House, Inc., Thornton, CO, US. Release Date: 20050705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Domestic Violence; Drug Abuse; Mental Disorders; Offspring; Parental Characteristics. Minor Descriptor: At Risk Populations; Behavior Problems; Child Welfare; Emotional Trauma; Mothers; Victimization. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Tests & Measures: Behavioral and Emotional Rating Scale; Global Severity Index; Child Behavior Checklist; Posttraumatic Stress Diagnostic Scale; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Jul, 2005.
AB - Children exposed to parental substance abuse, mental illness, and violence face profound challenges, including increased risk for emotional and behavioral problems, substance abuse, and victimization. In this article, we describe the characteristics of a sample of children of women entering treatment. These children had been exposed to domestic violence, frequent child welfare involvement, and residential instability. Parental entry into treatment affords treatment providers an opportunity to intervene early with these children, enabling them to offer supportive and preventive services and to help children build skills to avoid problems later. Treatment providers are encouraged to offer assessment and services to children of parents entering treatment, capitalizing on the opportunity to intervene early with a group of children who are at risk for problems with significant individual and social consequences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance abuse
KW - mental illness
KW - maternal trauma
KW - at risk children
KW - domestic violence
KW - child welfare involvement
KW - residential instability
KW - 2005
KW - Domestic Violence
KW - Drug Abuse
KW - Mental Disorders
KW - Offspring
KW - Parental Characteristics
KW - At Risk Populations
KW - Behavior Problems
KW - Child Welfare
KW - Emotional Trauma
KW - Mothers
KW - Victimization
KW - 2005
DO - 10.1002/jcop.20062
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06764-006&site=ehost-live&scope=site
UR - nancy@ahinc.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-06764-009
AN - 2005-06764-009
AU - Amaro, Hortensia
AU - Larson, Mary Jo
AU - Gampel, Joanne
AU - Richardson, Erin
AU - Savage, Andrea
AU - Wagler, Debra
T1 - Racial/Ethnic Differences in Social Vulnerability Among Women With Co-Occurring Mental Health and Substance Abuse Disorders: Implications for Treatment Services.
T3 - Serving the Needs of Women With Co-Occurring Disorders and a History of Trauma
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2005/07//
VL - 33
IS - 4
SP - 495
EP - 511
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Amaro, Hortensia, Bouve College of Health Sciences, 360 Huntington Avenue, Stearns Suite 503, Boston, MA, US, 02115
N1 - Accession Number: 2005-06764-009. Partial author list: First Author & Affiliation: Amaro, Hortensia; Northeastern University, Boston, MA, US. Release Date: 20050705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Mental Disorders; Racial and Ethnic Differences; Susceptibility (Disorders). Minor Descriptor: Blacks; Human Females; Mental Health Services; Latinos/Latinas. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Lifetime Exposure to Stressful Events scale; Global Severity Index; Addiction Severity Index DOI: 10.1037/t00025-000; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jul, 2005.
AB - Little attention has been given to racial/ethnic differences in studies of co-occurring disorders among women. In this article, we present findings from analyses conducted on the influence of racial/ethnic differences on the demographic and clinical profiles of 2,534 women in the Substance Abuse and Mental Health Services Administration-sponsored Women, Co-Occurring Disorders and Violence Study. Black and Hispanic women demonstrated more disadvantaged economic and social life conditions than White women. After controlling for socioeconomic differences, Hispanic women experienced more criminal justice involvement than others did, and both Black and Hispanic women were more likely to be exposed to community violence although they did not demonstrate more severe clinical symptoms than White women. In the design and delivery of services racial/ethnic differences should be considered, and research questions regarding underlying explanatory factors raised. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial differences
KW - ethnic differences
KW - disordered women
KW - substance use
KW - mental disorders
KW - mental health services
KW - comorbidity
KW - treatment services
KW - African Americans
KW - Hispanics
KW - Whites
KW - demographics
KW - 2005
KW - Comorbidity
KW - Drug Abuse
KW - Mental Disorders
KW - Racial and Ethnic Differences
KW - Susceptibility (Disorders)
KW - Blacks
KW - Human Females
KW - Mental Health Services
KW - Latinos/Latinas
KW - 2005
DO - 10.1002/jcop.20065
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06764-009&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-6366-7756
UR - h.amaro@neu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10406-006
AN - 2005-10406-006
AU - Garey, Joan
AU - Ferguson, Sherry A.
AU - Paule, Merle G.
T1 - Developmental and behavioral effects of acrylamide in Fischer 344 rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2005/07//Jul-Aug, 2005
VL - 27
IS - 4
SP - 553
EP - 563
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Garey, Joan, Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, 3900 NCTR Rd., Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2005-10406-006. PMID: 16087067 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Garey, Joan; Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20060522. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Development; Animal Ethology; Drug Dosages; Neurotoxicity; Neurotoxins. Minor Descriptor: Prenatal Exposure; Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul-Aug, 2005.
AB - Human exposures to acrylamide (ACR), a known neurotoxicant, can occur via a variety of substances, including cigarette smoke and the ingestion of certain carbohydrate-based foods cooked at high temperatures. In this study, Fischer 344 sperm plug-positive female rats were treated daily with ACR (0, 0.5, 1.0, 2.5, 5.0 or 10.0 mg/kg/day) by gavage beginning on gestation day 7. Dosing of dams ended when litters were born; pups received daily gavage at the same dose as their dam from postnatal day (PND) 1 through PND22. Pups were tested using a battery of behavioral assessments from PNDs 4-22. Statistically significant decreases in body weight were observed in pups exposed to ACR at doses as low as 1.0 mg/kg/day (treatment x day; repeated measures ANOVA, P < 0.0001). No statistically significant differences among treatment groups were observed in righting reflex, forelimb hang, or open field measures of activity. Statistically significant effects of ACR were observed at the 10 mg/kg/day dose on negative geotaxis performance (P < 0.01) and a linear trend in fall-time latencies on Rotarod performance on PNDs 21-22 (F < 0.05), with higher doses producing shorter latencies. These results suggest that ACR exposure produces deficits in development and motor coordination that are observable before weaning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developmental effects
KW - behavioral effects
KW - acrylamide
KW - Fischer rats
KW - neurotoxicity
KW - prenatal exposure
KW - postnatal exposure
KW - dosage
KW - 2005
KW - Animal Development
KW - Animal Ethology
KW - Drug Dosages
KW - Neurotoxicity
KW - Neurotoxins
KW - Prenatal Exposure
KW - Rats
KW - 2005
U1 - Sponsor: NCTR, FDA. Grant: 224-93-0001. Recipients: No recipient indicated
U1 - Sponsor: National Institute for Environmental Health Sciences, National Toxicology Program. Grant: 224-93-0001. Recipients: No recipient indicated
DO - 10.1016/j.ntt.2005.03.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10406-006&site=ehost-live&scope=site
UR - jgarey@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-07421-012
AN - 2005-07421-012
AU - Horton, Arthur Macneill Jr.
AU - Roberts, Charles
T1 - Derived trail making test cutoffs and malingering among substance abusers.
JF - International Journal of Neuroscience
JO - International Journal of Neuroscience
JA - Int J Neurosci
Y1 - 2005/07//
VL - 115
IS - 7
SP - 1083
EP - 1096
CY - United Kingdom
PB - Taylor & Francis
SN - 0020-7454
SN - 1563-5279
AD - Horton, Arthur Macneill Jr., 5903 Lone Oak Drive, Bethesda, MD, US, 20814
N1 - Accession Number: 2005-07421-012. PMID: 16051551 Partial author list: First Author & Affiliation: Horton, Arthur Macneill Jr.; Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Gordon & Breach Science Publishers, Inc.; Informa Healthcare. Release Date: 20050718. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Assessment; Cognitive Impairment; Cutting Scores; Drug Abuse; Malingering. Classification: Neuropsychological Assessment (2225); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Jul, 2005.
AB - The Trail Making test (TMT) is often used to screen for cognitive impairment in substance abusers. A possible limitation of the TMT in clinical settings is that substance abusers may malinger and give poor effort. Data from the Drug Abuse Treatment Outcome Study (DATOS) were analyzed to develop derived TMT cutoffs. Data were analyzed to determine number of substance abusers that fell beyond the upper end of the distribution of selected derived TMT scores at the 10, 5, and 1 percentiles. These percentiles were set for alcoholics (n = 1000), cocaine abusers (n = 4306), and heroin abusers (n = 1548) for TMT selected derived scores. Inspection of the selected TMT derived scores yielded an impression that the percentile values for the 3 sub-samples of primary drugs of abuse, alcohol, cocaine, and heroin, are actually very similar at each of the 3 percentile levels. This would suggest that these estimates are actually quite stable and reinforces the notion that they may be creditable estimates. The proper use of the derived TMT cutoff scores is to alert clinicians to the increasingly higher probability of poor effort when a substance abuser in one of the three groups scores beyond the one percent cutoff for the primary drug of abuse sample. Clearly, the use of these cutoffs needs further empirical validation before they would be considered as a single source to suggest malingering. Great caution is suggested in using these cutoff scores for clinical purposes with substance abusing patients in their current state of validation. In short, further research is warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trail making test
KW - malingering
KW - substance abusers
KW - cognitive impairment
KW - cutoff scores
KW - 2005
KW - Cognitive Assessment
KW - Cognitive Impairment
KW - Cutting Scores
KW - Drug Abuse
KW - Malingering
KW - 2005
DO - 10.1080/00207450590897914
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-07421-012&site=ehost-live&scope=site
UR - drmachorton@hotmail.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kresina, Thomas F.
AU - Bruce, R. Douglas
AU - Cargill, Victoria A.
AU - Cheever, Laura W.
T1 - Integrating Care for Hepatitis C Virus (HCV) and Primary Care for HIV for Injection Drug Users Coinfected with HIV and HCV.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/07/02/7/1/2005 Supplement
VL - 41
M3 - Article
SP - S83
EP - S88
SN - 10584838
AB - Injection drug use accounts for most of the incident infections with hepatitis C virus (HCV) and for at least one-third of new human immunodeficiency virus (HIV) infections. Coinfection with HCV and HIV presents complex and challenging medical conditions. Ensuring access to and maintaining care for HIV and HCV for drug users presents special challenges to the health care team that require a nonjudgmental attitude, experience, and patience. Care for HCV infection, however, can be used as an instrument to engage drug-using persons in ongoing primary care relationships. Common elements to both care for HCV infection and primary care for HIV infection are testing for and counseling about HCV and HIV, substance abuse and mental health services, social support, and subspecialty referral. These elements, in particular treatment for substance abuse, can be focal points for model care systems that provide integrative care for both HCV and HIV infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - Medical care
KW - Hepatitis C
KW - Substance abuse
KW - Mental health
KW - Pathological psychology
N1 - Accession Number: 17230326; Kresina, Thomas F. 1; Email Address: tk13v@nih.gov; Bruce, R. Douglas 2; Cargill, Victoria A. 3; Cheever, Laura W. 4; Affiliations: 1: Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse.; 2: Yale AIDS Program, Yale University School of Medicine, New Haven, Connecticut.; 3: Office of AIDS Research, National Institutes of Health, Bethesda.; 4: HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland.; Issue Info: 7/1/2005 Supplement, Vol. 41, pS83; Subject Term: HIV infections; Subject Term: Medical care; Subject Term: Hepatitis C; Subject Term: Substance abuse; Subject Term: Mental health; Subject Term: Pathological psychology; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Silverman, Toby
AU - Aebersold, Paul
AU - Landow, Laurence
AU - Lindsey, Kimberly
T1 - Regulatory perspectives on clinical trials for trauma, transfusion, and hemostasis.
JO - Transfusion
JF - Transfusion
Y1 - 2005/07/02/Jul2005 Supplement 1
VL - 45
M3 - Article
SP - 14S
EP - 21S
PB - Wiley-Blackwell
SN - 00411132
AB - Discusses regulatory perspectives on clinical trials for trauma, transfusion and hemostasis in the United States. Considerations for clinical trials in trauma; Considerations in transfusion avoidance; Considerations in the regulation of fibrin sealants.
KW - CLINICAL trials -- Law & legislation
KW - HEMOSTASIS
KW - BLOOD transfusion
KW - TRAUMATOLOGY
KW - FIBRIN tissue adhesive
KW - UNITED States
N1 - Accession Number: 17304209; Silverman, Toby 1; Email Address: silvermant@cber.fda.gov Aebersold, Paul 1 Landow, Laurence 1 Lindsey, Kimberly 1; Affiliation: 1: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: Jul2005 Supplement 1, Vol. 45, p14S; Subject Term: CLINICAL trials -- Law & legislation; Subject Term: HEMOSTASIS; Subject Term: BLOOD transfusion; Subject Term: TRAUMATOLOGY; Subject Term: FIBRIN tissue adhesive; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.0041-1132.2005.00157.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17304209&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lynch, Jeffrey
AU - Guo, Lel
AU - Gelebart, Pascal
AU - Chilibeck, Kaari
AU - Jian Xu
AU - Molkentin, Jeffery D.
AU - Agellon, Luis B.
AU - Michalak, Marek
T1 - Calreticulin signal upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascade.
JO - Journal of Cell Biology
JF - Journal of Cell Biology
Y1 - 2005/07/04/
VL - 170
IS - 1
M3 - Article
SP - 37
EP - 47
SN - 00219525
AB - We uncovered a new pathway of interplay between calreticulin and myocyteenhoncer factor (MEF) 2C, a cardiac-specific transcription factor. We establish that calreticulin works up- stream of calcineurin and MEF2C in a Ca2-dependent signal transduction cascade that links the endoplasmic reticulum and the nucleus during cardiac development. In the absence of calreticulin, translocation of MEF2C to the nucleus is compromised. This defect is reversed by calreticulin itself or by a constitutively active form of calcineurin. Furthermore, we show that expression of the calreticulin gene itself is regulated by MEF2C in vitro and in vivo and that, in turn, increased expression of caireticulin affects MEF2C transcriptional activity. The present findings provide a clear molecular explanation for the embryonic lethality observed in calreticulin-deficient mice and emphasize the importance of caireticulin in the early stages of cardiac development. Our study illustrates the existence of a positive feedback mechanism that ensures an adequate supply of releasable Ca is maintained within the cell for activation of calcineurin and, subsequently, for proper functioning of MEF2C. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Biology is the property of Rockefeller University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALRETICULIN
KW - TRANSCRIPTION factors
KW - MICROBIAL genetics
KW - ENDOPLASMIC reticulum
KW - CELLS
KW - GENETIC transcription
KW - GENETIC transduction
N1 - Accession Number: 17620981; Lynch, Jeffrey 1 Guo, Lel 2 Gelebart, Pascal 1 Chilibeck, Kaari 1 Jian Xu 3 Molkentin, Jeffery D. 3 Agellon, Luis B. 1,4 Michalak, Marek 1; Affiliation: 1: Department of Biochemistry Universily of Alberta 2: Hepatic Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079 3: Children's Hospital Medical Center, Molecular Cardiovascular Biology, Cincinnati, OH 45229 4: Canadian institutes of Health Research Group in the Molecular and Cell Biology of Lipids, Universily of Alberta, Edmonton, Alberta, Canada TÔG 2H7; Source Info: 7/4/2005, Vol. 170 Issue 1, p37; Subject Term: CALRETICULIN; Subject Term: TRANSCRIPTION factors; Subject Term: MICROBIAL genetics; Subject Term: ENDOPLASMIC reticulum; Subject Term: CELLS; Subject Term: GENETIC transcription; Subject Term: GENETIC transduction; Number of Pages: 11p; Document Type: Article
L3 - 10.1083/jcb2004121 56
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17620981&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Heller, David N.
AU - Peggins, James O.
AU - Nochetto, Cristina B.
AU - Smith, Michelle L.
AU - Chiesa, O. Alberto
AU - Moulton, Keesla
T1 - LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2005/07/05/
VL - 821
IS - 1
M3 - Article
SP - 22
EP - 30
SN - 15700232
AB - Abstract: Methods for the measurement of gentamicin concentration in several bovine tissues were developed and validated. A novel liquid chromatographic (LC) technique employed trifluoroacetic acid in the mobile phase so that all gentamicin components co-eluted. Analytes were ionized by positive-ion pneumatically assisted electrospray and detected by selected reaction monitoring (SRM) with an LC-tandem mass spectrometer (LC/MS/MS). Calibration of plasma and urine samples was based on tobramycin internal standard. Calibration of milk and kidney samples was based on external standard, due to variability of tobramycin response in these matrices. The extraction technique employed treatment with aqueous trichloroacetic acid to both precipitate protein and liberate gentamicin from the matrix. Milk samples had to be defatted by centrifugation prior to extraction. Urine samples were further cleaned up with C-18 solid phase extraction (SPE). These methods were validated for use in several residue depletion studies (reported elsewhere) to monitor the depletion of gentamicin in tissues under various dosing conditions. The plasma method was calibrated from 1 to 5000ng/mL in two ranges, with a limit of quantitation (LOQ) in the low range calculated at 3.3ng/mL. The milk method was calibrated from 2.5 to 2500ng/mL with an LOQ calculated at 4.5ng/mL. The urine method was designed for use at low levels, and was calibrated from 1 to 100ng/mL with an LOQ of 3.8ng/mL. The kidney method was primarily designed for analysis of small samples (approximately 100mg). This method was calibrated from 10 to 50,000ng/g with an LOQ of 26ng/g. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENTAMICIN
KW - AMINOGLYCOSIDES
KW - ANTIBACTERIAL agents
KW - BIOACCUMULATION
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - SPECTRUM analysis
KW - Gentamicin
KW - Kidney
KW - Liquid chromatography-tandem mass spectrometry
KW - Milk
KW - Plasma
KW - Quantification
KW - Residue analysis
KW - Urine
N1 - Accession Number: 17952801; Heller, David N.; Email Address: david.heller@fda.gov Peggins, James O. Nochetto, Cristina B. 1 Smith, Michelle L. 1 Chiesa, O. Alberto Moulton, Keesla; Affiliation: 1: Food and Drug Administration, FDA Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jul2005, Vol. 821 Issue 1, p22; Subject Term: GENTAMICIN; Subject Term: AMINOGLYCOSIDES; Subject Term: ANTIBACTERIAL agents; Subject Term: BIOACCUMULATION; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: SPECTRUM analysis; Author-Supplied Keyword: Gentamicin; Author-Supplied Keyword: Kidney; Author-Supplied Keyword: Liquid chromatography-tandem mass spectrometry; Author-Supplied Keyword: Milk; Author-Supplied Keyword: Plasma; Author-Supplied Keyword: Quantification; Author-Supplied Keyword: Residue analysis; Author-Supplied Keyword: Urine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jchromb.2005.04.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17952801&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sundin, Olof H.
AU - Leppert, Gregory S.
AU - Silva, Eduardo D.
AU - Jun-Ming Yanga
AU - Dharmaraj, Sharola
AU - Maumenee, Irene H.
AU - Santos, Luisa Coutinho
AU - Parsa, Cameron F.
AU - Traboulsi, Elias I.
AU - Broman, Karl W.
AU - DiBernardo, Cathy
AU - Sunness, Janet S.
AU - Toy, Jeffrey
AU - Weinberg, Ethan M.
T1 - Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2005/07/05/
VL - 102
IS - 27
M3 - Article
SP - 9553
EP - 9558
SN - 00278424
AB - Nanophthalmos is a rare disorder of eye development characterized by extreme hyperopia (farsightedness), with refractive error in the range of +8.00 to +25.00 diopters. Because the cornea and lens are normal in size and shape, hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. Thickening of these tissues is a general feature of axial hyperopia, whereas the Opposite occurs in myopia. We have mapped recessive nanophthalmos to a unique locus at 11q23.3 and identified four independent mutations in MFRP, a gene that is selectively expressed in the eye and encodes a protein with homology to Tolloid proteases and the Wnt-binding domain of the Frizzled transmembrane receptors. This gene is not critical for retinal function, as patients entirely lacking MFRP can still have good refraction-corrected vision, produce clinically normal electro-retinograms, and show only modest anomalies in the dark adaptation of photo receptors. MFRP appears primarily devoted to regulating axial length of the eye. It remains to be determined whether natural variation in its activity plays a role in common refractive errors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPEROPIA
KW - EYE -- Refractive errors
KW - PROTEOLYTIC enzymes
KW - RETINA
KW - HOMOLOGY (Biology)
KW - POSTERIOR segment (Eye)
KW - eye
KW - genetics
KW - morphology
KW - nanophthalmos
N1 - Accession Number: 17733317; Sundin, Olof H. 1,2; Email Address: osundin@jhmi.edu Leppert, Gregory S. 1,3 Silva, Eduardo D. 1,4,5 Jun-Ming Yanga 1,6 Dharmaraj, Sharola 1,4,7 Maumenee, Irene H. 4,8 Santos, Luisa Coutinho 9 Parsa, Cameron F. 9 Traboulsi, Elias I. 10 Broman, Karl W. 11 DiBernardo, Cathy 12 Sunness, Janet S. 12,13 Toy, Jeffrey 1,14 Weinberg, Ethan M.; Affiliation: 1: Laboratory of Developmental Genetics, Johns Hopkins University, Baltimore, MD 21287 2: Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21287 3: National Institutes of Health/Foundation for Advanced Education in the Sciences, Bethesda, MD 20814. 4: Johns Hopkins Clinic for Hereditary Eye Diseases, Johns Hopkins University, Baltimore, MD 21287 5: Department of Ophthalmology, University of Coimbra, 3000-033 Coimbra, Portugal 6: National Institutes of Health/National Cancer Institute, Bethesda, MD 20892 7: Massachusetts Eye and Ear Infirmary, Boston, MA 02114. 8: Krieger Center for Pediatric Ophthalmology, Johns Hopkins University, Baltimore, MD 21287 9: Instituto de Oftalmologia Dr. Gama Pinto, 1169-019 Lisbon, Portugal 10: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 11: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287 12: Ocular Imaging and Low Vision Clinics, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287 13: Department of Ophthalmology, Greater Baltimore Medical Center, Towson, MD 21204 14: Food and Drug Administration, Rockville, MD 20857; Source Info: 7/5/2005, Vol. 102 Issue 27, p9553; Subject Term: HYPEROPIA; Subject Term: EYE -- Refractive errors; Subject Term: PROTEOLYTIC enzymes; Subject Term: RETINA; Subject Term: HOMOLOGY (Biology); Subject Term: POSTERIOR segment (Eye); Author-Supplied Keyword: eye; Author-Supplied Keyword: genetics; Author-Supplied Keyword: morphology; Author-Supplied Keyword: nanophthalmos; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0501451102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17733317&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Guor-Cheng
AU - Wu, Yuh-Shen
AU - Chen, Jyh-Cherng
AU - Fu, Peter Pi-Cheng
AU - Chang, Cheng-Nan
AU - Ho, Tse-Tsung
AU - Chen, Ming-Hsiang
T1 - Characteristic study of polycyclic aromatic hydrocarbons for fine and coarse particulates at Pastureland near Industrial Park sampling site of central Taiwan
JO - Chemosphere
JF - Chemosphere
Y1 - 2005/07/08/
VL - 60
IS - 3
M3 - Article
SP - 427
EP - 433
SN - 00456535
AB - Abstract: The concentrations of ambient air polycyclic aromatic hydrocarbons were measured in a farm area (Tunghai University Pastureland) between August 2001 and April 2002 in central Taiwan, Taichung. Particle-bound polycyclic aromatic hydrocarbons (PAHs) were collected on quartz filters, the collected sample was extracted with a dichloromethane (DCM)/n-hexane mixture (50/50, v/v) for 24h, and then the extracts were subjected to gas chromatography–mass spectrometric analysis. The PM2.5 (fine particulate) and PM2.5–10 (coarse particulate) total PAHs concentrations at the Tunghai University Pastureland sampling site were found to be 180.62ngm−3 and 164.98ngm−3, respectively. In general, the concentrations of polycyclic aromatic hydrocarbons were higher in spring and winter than those of summer and autumn for either PM2.5 or PM2.5–10 in Pastureland in central Taiwan. Moreover, coarse particulates are the dominant species during the dust storm season (March and April) in central Taiwan. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCYCLIC aromatic hydrocarbons
KW - FARMS
KW - MASS spectrometry
KW - GAS chromatography
KW - TAIWAN
KW - Dust storm
KW - GC–MS
KW - PAHs
KW - Pastureland
KW - PM2.5–10
KW - PM2.5
N1 - Accession Number: 17990587; Fang, Guor-Cheng 1; Email Address: gcfang@sunrise.hkc.edu.tw Wu, Yuh-Shen 1 Chen, Jyh-Cherng 1 Fu, Peter Pi-Cheng 2 Chang, Cheng-Nan 3 Ho, Tse-Tsung 3 Chen, Ming-Hsiang 3; Affiliation: 1: Department of Environmental Engineering, Hungkuang University, Sha-Lu, Taichung 433, Taiwan 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Department of Environmental Science, Tunghai University, Taichung 407, Taiwan; Source Info: Jul2005, Vol. 60 Issue 3, p427; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: FARMS; Subject Term: MASS spectrometry; Subject Term: GAS chromatography; Subject Term: TAIWAN; Author-Supplied Keyword: Dust storm; Author-Supplied Keyword: GC–MS; Author-Supplied Keyword: PAHs; Author-Supplied Keyword: Pastureland; Author-Supplied Keyword: PM2.5–10; Author-Supplied Keyword: PM2.5; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.chemosphere.2004.12.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17990587&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cardis, E.
AU - Vrijheid, M.
AU - Gilbert, E.
AU - Hakama, M.
AU - Hill, C.
AU - Howe, G.
AU - Kaldor, J.
AU - Muirhead, C. R.
AU - Schubauer-Berigan, M.
AU - Yoshimura, T.
AU - Blettner, M.
T1 - Risk of cancer after low doses of ionising radiation--retrospective cohort study in 15 countries.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2005/07/09/
VL - 331
IS - 7508
M3 - Article
SP - 77
EP - 80
SN - 09598146
AB - Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and medical diagnostic exposures. Design Multinational retrospective cohort study of cancer mortality. Setting Cohorts of workers in the nuclear industry in 15 countries. Participants 407 391 workers individually monitored for external radiation with a total follow-up of 5.2 million person years. Main outcome measurements Estimates of excess relative risks per sievert (Sv) of radiation dose for mortality from cancers other than leukaemia and from leukaemia excluding chronic lymphocytic leukaemia, the main causes of death considered by radiation protection authorities. Results The excess relative risk for cancers other than leukaemia was 0.97 per Sv, 95% confidence interval 0.14 to 1.97. Analyses of causes of death related or unrelated to smoking indicate that, although confounding by smoking may be present, it is unlikely to explain all of this increased risk. The excess relative risk for leukaemia excluding chronic lymphocytic leukaemia was 1.93 per Sv (< 0 to 8.47). On the basis of these estimates, 1-2% of deaths from cancer among workers in this cohort may be attributable to radiation. Conclusions These estimates, from the largest study of nuclear workers ever conducted, are higher than, but statistically compatible with, the risk estimates used for current radiation protection standards. The results suggest that there is a small excess risk of cancer, even at the low doses and dose rates typically received by nuclear workers in this study. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMJ: British Medical Journal (International Edition) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - DISEASES
KW - RADIATION
KW - IONIZING radiation
KW - HEALTH risk assessment
KW - HEALTH
N1 - Accession Number: 17593469; Cardis, E. 1; Email Address: cardis@iarc.fr Vrijheid, M. 1 Gilbert, E. 2 Hakama, M. 3 Hill, C. 4 Howe, G. 5 Kaldor, J. 6 Muirhead, C. R. 7 Schubauer-Berigan, M. 8 Yoshimura, T. 9 Blettner, M. 10; Affiliation: 1: International Agency for Research on Cancer, Lyons, France 2: Radiation Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 3: University of Tampere, Tampere, Finland 4: Institut Gustave-Roussy, Villejuif, France 5: Mailman School of Public Health, Columbia University, New York, New York 6: National Centre in HIV Epidemiology and Clinical Research, Sydney, NSW, Australia 7: Radiation Protection Division, Health Protection Agency, Chilton, Didcot, Oxfordshire 8: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. 9: Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan 10: Institute of Medical Biostatistics, Epidemiology and Informatics, University of Mainz, Germany,; Source Info: 7/9/2005, Vol. 331 Issue 7508, p77; Subject Term: CANCER; Subject Term: DISEASES; Subject Term: RADIATION; Subject Term: IONIZING radiation; Subject Term: HEALTH risk assessment; Subject Term: HEALTH; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rinaldi, James J.
T1 - Change is nothing to fear.
JO - Federal Times
JF - Federal Times
J1 - Federal Times
PY - 2005/07/11/
Y1 - 2005/07/11/
VL - 41
IS - 22
M3 - Article
SP - 21
EP - 21
SN - 00149233
AB - Focuses on the decision of the U.S. Food and Drug Administration to consolidate its information technology (IT) system to illustrate the need for government managers to accept change without fear. Actions taken by the agency to combat uncertainties in the project; Benefits of the consolidated IT system; Tips for agencies that will consider IT consolidation.
KW - INFORMATION technology
KW - UNITED States. Food & Drug Administration
KW - GOVERNMENT executives
KW - GOVERNMENT agencies
KW - UNITED States
N1 - Accession Number: 17683909; Source Information: 7/11/2005, Vol. 41 Issue 22, p21; Subject Term: INFORMATION technology; Subject Term: UNITED States. Food & Drug Administration; Subject Term: GOVERNMENT executives; Subject Term: GOVERNMENT agencies; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 1/2p; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Ford, Michael J.
AU - Deibel, Michael A.
AU - Tomkins, Bruce A.
AU - Van Berkel, Gary J.
T1 - Quantitative Thin-Layer Chromatography/Mass Spectrometry Analysis of Caffeine Using a Surface Sampling Probe Electrospray Ionization Tandem Mass Spectrometry System.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2005/07/15/
VL - 77
IS - 14
M3 - Article
SP - 4385
EP - 4389
SN - 00032700
AB - Quantitative determination of caffeine on reversed-phase C8 thin-layer chromatography plates using a surface sampling electrospray ionization system with tandem mass spectrometry detection is reported. The thin-layer chromatography/electrospray tandem mass spectrometry method employed a deuteriumelabeled caffeine internal standard and selected reaction monitoring detection. Up to nine parallel caffeine bands on a single plate were sampled in a single surface scanning experiment requiring 35 mm at a surface scan rate of 44 μm/s. A reversed- phase HPLC/UV caffeine assay was developed in parallel to assess the mass specfrometry method performance. Limits of detection for the HPLC/UV and thin-layer chromatography/electrospray tandem mass specfrometry methods determined from the calibration curve Statistics were 0.20 ng injected (0.50 μL) and 1.0 ng spotted on the plate, respectively. Spike recoveries with standards and real samples ranged between 97 and 106% for both methods. The caffeine content of three diet soft drinks (Diet Coke, Diet Cherry Coke, Diet Pepsi) and three diet sport drinks (Diet Turbo Tea, Speed Stack Grape, Speed Stack Fruit Punch) was measured. The HPLC/UV and mass spectrometry determinations were in general agreement, and these values were consistent with the quoted values for two of the three diet colas. In the case of Diet Cherry Coke and the diet sports drinks, the determined caffeine amounts using both methods were consistently higher (by ∼8% or more) than the literature values. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLXANTHINES
KW - HIGH performance liquid chromatography
KW - CHROMATOGRAPHIC analysis
KW - MASS spectrometry
KW - COAL -- Carbonization
KW - PHYSICAL measurements
N1 - Accession Number: 17733686; Ford, Michael J. 1 Deibel, Michael A. 2 Tomkins, Bruce A. 2 Van Berkel, Gary J. 2; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. 2: Organic and Biological Mass Spectrometry Group, Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6131.; Source Info: 7/15/2005, Vol. 77 Issue 14, p4385; Subject Term: METHYLXANTHINES; Subject Term: HIGH performance liquid chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MASS spectrometry; Subject Term: COAL -- Carbonization; Subject Term: PHYSICAL measurements; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - La Grenade, Lois
AU - Lee, Lauren
AU - Weaver, Joyce
AU - Bonnel, Renan
AU - Karwoski, Claudia
AU - Governale, Laura
AU - Brinker, Allen
T1 - Comparison of Reporting of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Association with Selective COX-2 Inhibitors.
JO - Drug Safety
JF - Drug Safety
Y1 - 2005/07/15/
VL - 28
IS - 10
M3 - Article
SP - 917
EP - 924
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are closely related severe acute life-threatening, drug-induced skin disorders. The US FDA Adverse Events Reporting System (AERS) has received reports of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with the use of the recently introduced selective cyclo-oxygenase (COX)-2 inhibitor NSAIDs, two of which are also sulfonamides. Objective: The objective of this study is to review cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA associated with the use of the selective COX-2 inhibitor NSAIDs celecoxib, rofecoxib and valdecoxib, and to compare reporting rates of the two conditions associated with these drugs to each other, meloxicam (an oxicam NSAID that came on the US market at a similar time) and the background incidence rate. Methods: We reviewed all US cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the FDA AERS database associated with the use of celecoxib, rofecoxib, valdecoxib and meloxicam since these agents were first marketed. We utilised AERS and drug use data to calculate reporting rates for each drug after the first 2 years of marketing. We obtained the background rate from the medical literature. Results: Up to the end of March 2004, there were 63 cases of Stevens-Johnson syndrome/toxic epidermal necrolysis reported with valdecoxib use, 43 with celecoxib, 17 with rofecoxib (the non-sulfonamide coxib) and none for meloxicam. In the first 2 years of marketing the reporting rate for Stevens-Johnson syndrome/toxic epidermal necrolysis with valdecoxib was 49 cases per million person-years of use, 6 cases per million person-years for celecoxib and 3 cases per million person-years for rofecoxib. The reporting rates for the sulfonamide coxibs were substantially higher than the background rate of 1.9 cases per million population per year, with the valdecoxib rate being 8–9 times that of celecoxib and approximately 25 times that of the background rate. Conclusion: There is a strong association between Stevens-Johnson syndrome/toxic epidermal necrolysis and the use of the sulfonamide COX-2 inhibitors, particularly valdecoxib. Physicians should be aware of the possibility of this serious life-threatening event when prescribing these drugs and advise patients to discontinue use at the earliest possible sign or symptom. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYNDROMES
KW - SKIN diseases
KW - DRUGS -- Side effects
KW - EPIDERMIS
KW - NONSTEROIDAL anti-inflammatory agents
KW - CYCLOOXYGENASE 2
KW - Celecoxib
KW - Cyclo oxygenase 2 inhibitors
KW - Meloxicam
KW - Rofecoxib
KW - Stevens Johnson syndrome
KW - Toxic epidermal necrolysis
KW - Valdecoxib
N1 - Accession Number: 18486641; La Grenade, Lois 1; Email Address: lagrenadel@cder.fda.gov Lee, Lauren 1 Weaver, Joyce 1 Bonnel, Renan 1 Karwoski, Claudia 1 Governale, Laura 1 Brinker, Allen 1; Affiliation: 1: Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2005, Vol. 28 Issue 10, p917; Subject Term: SYNDROMES; Subject Term: SKIN diseases; Subject Term: DRUGS -- Side effects; Subject Term: EPIDERMIS; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: CYCLOOXYGENASE 2; Author-Supplied Keyword: Celecoxib; Author-Supplied Keyword: Cyclo oxygenase 2 inhibitors; Author-Supplied Keyword: Meloxicam; Author-Supplied Keyword: Rofecoxib; Author-Supplied Keyword: Stevens Johnson syndrome; Author-Supplied Keyword: Toxic epidermal necrolysis; Author-Supplied Keyword: Valdecoxib; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ackerman, Amanda H.
AU - Creed, Patricia A.
AU - Parks, Amy N.
AU - Fricke, Michael W.
AU - Schwegel, Carol A.
AU - Creed, John T.
AU - Heitkemper, Douglas T.
AU - Vela, Nohora P.
T1 - Comparison of a Chemical and Enzymatic Extraction of Arsenic from Rice and an Assessment of the Arsenic Absorption from Contaminated Water by Cooked Rice.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2005/07/15/
VL - 39
IS - 14
M3 - Article
SP - 5241
EP - 5246
SN - 0013936X
AB - Rice is a target food for arsenic speciation based analyses because of its relatively high arsenic concentration and per capita consumption rates. Improved speciation data for rice can be helpful in estimating inorganic arsenic exposures in the U.S. and in endemic populations. The inorganic arsenic exposure for cooked rice should include both the arsenic in raw rice plus the arsenic absorbed from the water used to prepare it. The amount of arsenic absorbed from water by rice during preparation was assessed using five different types of rice cooked in both contaminated drinking water and arsenic-free reagent water. The rice samples were extracted using trifluoroacetic acid (TFA) and speciated using IC-ICP-MS. The TFA procedure was able to extract 84-104% of the arsenic (As) from the five different cooked rice samples. Chromatographic recoveries ranged from 99% to 116%. The dimethylarsinic acid (DMA) and inorganic arsenic concentration ranged from 22 to 270 ng of As/g of rice and from 31 to 108 ng of As/g of rice, respectively, for samples cooked in reagent water. The overall recoveries, which relate the sum of the chromatographic species back to the total digested concentration, ranged from 89% to 117%. The absorption of arsenic by rice from the total volume of water [1:1 to 4:1 (water:rice)] used in cooking was between 89% and 105% for two different contaminated drinking water samples. A comparison of the TFA extraction to an enzymatic extraction was made using the five rice samples and NIST 1568a rice flour. The two extraction procedures produced good agreement for inorganic arsenic, DMA, and the overall recovery. Through the use of IC-ESI-MS/MS with a parent ion of m/z 153 and fragment ions of m/z 138, 123, and 105, the structure dimethylthioarsinic acid was tentatively identifird in two of the rice samples using the enzymatic extraction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Arsenic
KW - Native element minerals
KW - Water pollution
KW - Drinking water
KW - Rice
KW - Fresh water
N1 - Accession Number: 17702760; Ackerman, Amanda H. 1; Creed, Patricia A. 1; Email Address: Creed.Jack@epa.gov.; Parks, Amy N. 1,2; Fricke, Michael W. 3; Schwegel, Carol A. 2; Creed, John T. 1; Heitkemper, Douglas T. 2; Vela, Nohora P. 2; Affiliations: 1: Microbiological and Chemical Exposure Assessment Research Division, NERL, ORDJ.; 2: Forensic Chemistry Center, United States Food and Drug Administration, Cincinnati, Ohio 45249; 3: United States Environmental Protection Agency, Cincinnati, Ohio 45268,; Issue Info: 7/15/2005, Vol. 39 Issue 14, p5241; Thesaurus Term: Arsenic; Thesaurus Term: Native element minerals; Thesaurus Term: Water pollution; Thesaurus Term: Drinking water; Thesaurus Term: Rice; Thesaurus Term: Fresh water; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111160 Rice Farming; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Perez-Gracia, Jose Luis
AU - Muñoz, Maria
AU - Williams, Grant
AU - Wu, Jun
AU - Carrasco, Eva
AU - Garcia-Ribas, Ignacio
AU - Peiro, Ana
AU - Lopez-Picazo, Jose Maria
AU - Gurpide, Alfonso
AU - Chopitea, Ana
AU - Martín-Algarra, Salvador
AU - García-Foncillas, Jesus
AU - Blatter, Johannes
T1 - Assessment of the value of confirming responses in clinical trials in oncology
JO - European Journal of Cancer
JF - European Journal of Cancer
Y1 - 2005/07/15/
VL - 41
IS - 11
M3 - Article
SP - 1528
EP - 1532
SN - 09598049
AB - Abstract: The requirement for a second assessment to confirm initial tumour response is required by all response guidelines. Its rationale, however, is not clear. We have conducted this study to compare validity of response rate assessment determined with and without secondary confirmation. Using specified criteria, nine trials of one single cytotoxic drug including 416 patients were selected from a pharmaceutical database. Objective response rates were determined by a single determination and by two separate determinations. 81 responses (19.5%, [15.8–23.6%]) were scored by the confirmation method and 97 responses (23.3% [19.3–27.7%]) by the no-confirmation method. The Kappa (κ) coefficient of 0.89 indicates good agreement between both methods. This is the first study that systematically compares response rates calculated with and without performing response confirmation. Results show good agreement between both methods. We suggest that assessing response without confirmation may be the preferred method. These results should be confirmed by additional studies in a variety of cancer settings. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL medicine
KW - CLINICAL trials
KW - MEDICAL research
KW - PUBLIC opinion polls
KW - Clinical trials
KW - Response assessment
KW - Response guidelines
N1 - Accession Number: 18156607; Perez-Gracia, Jose Luis 1; Email Address: jlgracia@unav.es Muñoz, Maria 2 Williams, Grant 3 Wu, Jun 4 Carrasco, Eva 2 Garcia-Ribas, Ignacio 2 Peiro, Ana 2 Lopez-Picazo, Jose Maria 1 Gurpide, Alfonso 1 Chopitea, Ana 1 Martín-Algarra, Salvador 1 García-Foncillas, Jesus 1 Blatter, Johannes 5; Affiliation: 1: Medical Oncology Department, Clínica Universitaria de Navarra, Avenida de Pío XII 36, 31008 Pamplona, Spain 2: Clinical Research Department, Eli Lilly and Company, Madrid, Spain 3: US Food and Drug Administration, USA 4: Clinical Research Department, Eli Lilly and Company Indianapolis, USA 5: Clinical Research Department, Eli Lilly and Company, Frankfort, Germany; Source Info: Jul2005, Vol. 41 Issue 11, p1528; Subject Term: CLINICAL medicine; Subject Term: CLINICAL trials; Subject Term: MEDICAL research; Subject Term: PUBLIC opinion polls; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Response assessment; Author-Supplied Keyword: Response guidelines; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ejca.2005.01.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wagner, R. Doug
AU - Cerniglia, Carl E.
T1 - Antimicrobial susceptibility patterns of competitive exclusion bacteria applied to newly hatched chickens
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2005/07/15/
VL - 102
IS - 3
M3 - Article
SP - 349
EP - 353
SN - 01681605
AB - Abstract: Competitive exclusion (CE) products are mixtures of obligate and facultative anaerobic bacteria applied to poultry hatchlings for prevention of Salmonella colonization. These mixtures have the potential to introduce bacteria with undesirable antimicrobial drug resistance traits into the human food supply. Antimicrobial drug susceptibilities of 27 obligate and facultative anaerobes isolated from a commercial CE product were evaluated with a microdilution minimal inhibitory concentration (MIC) assay. Bacteroides distasonis and Bacteroides fragilis isolates were resistant to tetracycline and other antimicrobial drugs. An Escherichia coli isolate was resistant to four antimicrobial drugs: erythromycin, penicillin, vancomycin, and tylosin. Erythromycin-resistant enterococci and vancomycin-resistant Lactococcus lactis isolates in the CE product were detected. These findings suggest that more work needs to be done to assess the potential effects of CE product use in poultry on the food supply. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poultry
KW - Escherichia
KW - Salmonella
KW - Drug resistance
KW - Anaerobic
KW - Antimicrobial drug resistance
KW - Antimicrobial susceptibility testing
KW - Competitive exclusion
N1 - Accession Number: 18141645; Wagner, R. Doug; Email Address: dwagner@nctr.fda.gov; Cerniglia, Carl E. 1; Affiliations: 1: Microbiology Division, HFT-250, FDA National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, United States; Issue Info: Jul2005, Vol. 102 Issue 3, p349; Thesaurus Term: Poultry; Thesaurus Term: Escherichia; Thesaurus Term: Salmonella; Subject Term: Drug resistance; Author-Supplied Keyword: Anaerobic; Author-Supplied Keyword: Antimicrobial drug resistance; Author-Supplied Keyword: Antimicrobial susceptibility testing; Author-Supplied Keyword: Competitive exclusion; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2004.11.034
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wokovich, A.M.
AU - Spencer, J.A.
AU - Westenberger, B.J.
AU - Buhse, L.F.
AU - Jasper, J.P.
T1 - Stable isotopic composition of the active pharmaceutical ingredient (API) naproxen
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2005/07/15/
VL - 38
IS - 4
M3 - Article
SP - 781
EP - 784
SN - 07317085
AB - Abstract: A survey of the multi-stable isotopic composition of an active pharmaceutical ingredient (API), naproxen, was performed to assess the potential of Isotope Ratio Mass Spectrometry (IRMS) to distinguish the provenance of APIs. Twenty-six lots of naproxen from six manufacturers representing four countries (Italy, India, Ireland, and the USA) were analyzed for three isotope ratios (13C/12C, 18O/16O, and D/H). The samples were analyzed by either Elemental Analyzer/Isotope Ratio Mass Spectrometry (EA/IRMS: carbon (δ 13C)) or by Thermal Conversion-EA/IRMS (TCEA/IRMS: hydrogen (δD) and oxygen (δ 18O)). Bivariate and trivariate isotope ratio graphs for naproxen show marked clustering of the data for five out of the six naproxen manufacturers, suggesting that IRMS may be a plausible means to screen for manufacturer of given APIs. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NAPROXEN
KW - ISOTOPES
KW - MASS spectrometry
KW - NONSTEROIDAL anti-inflammatory agents
KW - δ 13C
KW - δ 18O
KW - δD
KW - Active pharmaceutical ingredient
KW - API
KW - IRMS
KW - Isotope ratio
KW - Isotope Ratio Mass Spectrometry
KW - Naproxen
N1 - Accession Number: 18027865; Wokovich, A.M. 1; Email Address: wokovicha@cder.fda.gov Spencer, J.A. 1 Westenberger, B.J. 1 Buhse, L.F. 1 Jasper, J.P. 2; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA 2: Molecular Isotope Technologies, LLC, 8 Old Oak Lane, Niantic, CT 06357-1815, USA; Source Info: Jul2005, Vol. 38 Issue 4, p781; Subject Term: NAPROXEN; Subject Term: ISOTOPES; Subject Term: MASS spectrometry; Subject Term: NONSTEROIDAL anti-inflammatory agents; Author-Supplied Keyword: δ 13C; Author-Supplied Keyword: δ 18O; Author-Supplied Keyword: δD; Author-Supplied Keyword: Active pharmaceutical ingredient; Author-Supplied Keyword: API; Author-Supplied Keyword: IRMS; Author-Supplied Keyword: Isotope ratio; Author-Supplied Keyword: Isotope Ratio Mass Spectrometry; Author-Supplied Keyword: Naproxen; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jpba.2005.02.033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, C.
AU - Sadovova, N.
AU - Fu, X.
AU - Schmued, L.
AU - Scallet, A.
AU - Hanig, J.
AU - Slikker, W.
T1 - The role of the N-methyl-d-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture
JO - Neuroscience
JF - Neuroscience
Y1 - 2005/07/15/
VL - 132
IS - 4
M3 - Article
SP - 967
EP - 977
SN - 03064522
AB - Abstract: Recent data suggest that anesthetic drugs may cause widespread and dose-dependent apoptotic neurodegeneration during development. The window of vulnerability to this neurotoxic effect, particularly with N-methyl-d-aspartate (NMDA) antagonists such as ketamine, is restricted to the period of synaptogenesis. The purposes of this study are to determine whether treatment of forebrain cultures with ketamine results in a dose-related increase in neurotoxicity and whether upregulation of NMDA receptor subunit NR1 promotes ketamine-induced apoptosis. Forebrain cultures were treated for 12 h with 0.1, 1, 10 and 20 μM ketamine or co-incubated with NR1 antisense oligonucleotide (2 μM). After washout of the ketamine, cultures were kept in serum-containing medium (in presence of glutamate) for 24 h. Application of ketamine (10 and 20 μM) resulted in a substantial increase in DNA fragmentation as measured by cell death enzyme-linked immunosorbent assay, increased number of terminal dUTP nick-end labeling positive cells, and a reduction in mitochondrial metabolism of the dye 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide. No significant effect was seen in the release of lactate dehydrogenase, indicating that cell death presumably occurred via an apoptotic mechanism. Co-incubation of ketamine with NR1 antisense significantly reduced ketamine-induced apoptosis. Western analysis showed that neurotoxic concentrations of ketamine increased Bax and NR1 protein levels. NR1 antisense prevented this increase caused by ketamine, suggesting that ketamine-induced cell death is associated with a compensatory upregulation of the NMDA receptor. These data suggest that NR1 antisense offers neuroprotection from apoptosis in vitro, and that upregulation of the NR1 following ketamine administration is, at least, partially responsible for the observed apoptosis. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CELL death
KW - BLOOD plasma
KW - LACTATE dehydrogenase
KW - 2-d-l-aminophosphonovaleric acid ( d-APV )
KW - 3-(4
KW - 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide ( MTT )
KW - 3-dione ( CNQX )
KW - 5-dimethylthiazole-2-yl)-2
KW - 5-diphenyltetrazolium bromide ( MTT )
KW - 6-cyano-7-nitroquinoxaline-2
KW - 6-cyano-7-nitroquinoxaline-2,3-dione ( CNQX )
KW - antagonist
KW - antisense oligonucleotide
KW - apoptosis
KW - dl-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ( AMPA )
KW - Dulbecco’s modified Eagle’s medium ( DMEM )
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - glial fibrillary acidic protein ( GFAP )
KW - ketamine
KW - lactate dehydrogenase ( LDH )
KW - N-methyl-d-aspartate ( NMDA )
KW - neurodegeneration
KW - NMDA receptor
KW - oligonucleotide ( ODN )
KW - phencyclidine ( PCP )
KW - phosphate-buffered saline ( PBS )
KW - polysialic acid neural cell adhesion molecule ( PSA-NCAM )
KW - postnatal day ( PND )
KW - terminal dUTP nick-end labeling ( TUNEL )
N1 - Accession Number: 17700188; Wang, C. 1; Email Address: cwang@nctr.fda.gov Sadovova, N. 2 Fu, X. 3 Schmued, L. 1 Scallet, A. 1 Hanig, J. 4 Slikker, W. 1; Email Address: wslikker@nctr.fda.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, Food and Drug Administration, Jefferson, AR 72079-0502, USA 2: Charles River Laboratories, Jefferson, AR, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA 4: Center for Drug Evaluation and Research, FDA, Rockville, MD, USA; Source Info: Jul2005, Vol. 132 Issue 4, p967; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: BLOOD plasma; Subject Term: LACTATE dehydrogenase; Author-Supplied Keyword: 2-d-l-aminophosphonovaleric acid ( d-APV ); Author-Supplied Keyword: 3-(4; Author-Supplied Keyword: 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: 3-dione ( CNQX ); Author-Supplied Keyword: 5-dimethylthiazole-2-yl)-2; Author-Supplied Keyword: 5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: 6-cyano-7-nitroquinoxaline-2; Author-Supplied Keyword: 6-cyano-7-nitroquinoxaline-2,3-dione ( CNQX ); Author-Supplied Keyword: antagonist; Author-Supplied Keyword: antisense oligonucleotide; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: dl-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ( AMPA ); Author-Supplied Keyword: Dulbecco’s modified Eagle’s medium ( DMEM ); Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: ketamine; Author-Supplied Keyword: lactate dehydrogenase ( LDH ); Author-Supplied Keyword: N-methyl-d-aspartate ( NMDA ); Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: NMDA receptor; Author-Supplied Keyword: oligonucleotide ( ODN ); Author-Supplied Keyword: phencyclidine ( PCP ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: polysialic acid neural cell adhesion molecule ( PSA-NCAM ); Author-Supplied Keyword: postnatal day ( PND ); Author-Supplied Keyword: terminal dUTP nick-end labeling ( TUNEL ); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.neuroscience.2005.01.053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mönkkönen, P.
AU - Pai, P.
AU - Maynard, A.
AU - Lehtinen, K.E.J.
AU - Hämeri, K.
AU - Rechkemmer, P.
AU - Ramachandran, G.
AU - Prasad, B.
AU - Kulmala, M.
T1 - Fine particle number and mass concentration measurements in urban Indian households
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2005/07/15/
VL - 347
IS - 1-3
M3 - Article
SP - 131
EP - 147
SN - 00489697
AB - Abstract: Fine particle number concentration (D p>10 nm, cm−3), mass concentrations (approximation of PM2.5, μg m−3) and indoor/outdoor number concentration ratio (I/O) measurements have been conducted for the first time in 11 urban households in India, 2002. The results indicate remarkable high indoor number and mass concentrations and I/O number concentration ratios caused by cooking. Besides cooking stoves that used liquefied petroleum gas (LPG) or kerosene as the main fuel, high indoor concentrations can be explained by poor ventilation systems. Particle number concentrations of more than 300,000 cm−3 and mass concentrations of more than 1000 μg m−3 were detected in some cases. When the number and mass concentrations during cooking times were statistically compared, a correlation coefficient r>0.50 was observed in 63% of the households. Some households used other fuels like wood and dung cakes along with the main fuel, but also other living activities influenced the concentrations. In some areas, outdoor combustion processes had a negative impact on indoor air quality. The maximum concentrations observed in most cases were due to indoor combustion sources. Reduction of exposure risk and health effects caused by poor indoor air in urban Indian households is possible by improving indoor ventilation and reducing penetration of outdoor particles. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - BUILDINGS -- Environmental engineering
KW - AIR quality
KW - INDIA
KW - India
KW - Indoor aerosols
KW - Mass concentration
KW - Number concentration
KW - Urban aerosols
N1 - Accession Number: 18222036; Mönkkönen, P. 1; Email Address: petteri.monkkonen@helsinki.fi Pai, P. 2 Maynard, A. 3 Lehtinen, K.E.J. 1 Hämeri, K. 1,4 Rechkemmer, P. 5 Ramachandran, G. 5 Prasad, B. 2 Kulmala, M. 1; Affiliation: 1: University of Helsinki, Department of Physical Sciences, P.O. Box 64, 00014 Helsinki, Finland 2: University of Mysore, Visvavidyanilaya Karya Soudha, Crawford Hall, 570005, India 3: National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA 4: Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland 5: University of Minnesota, Division of Environmental and Occupational Health, MN 55455, USA; Source Info: Jul2005, Vol. 347 Issue 1-3, p131; Subject Term: AEROSOLS (Sprays); Subject Term: BUILDINGS -- Environmental engineering; Subject Term: AIR quality; Subject Term: INDIA; Author-Supplied Keyword: India; Author-Supplied Keyword: Indoor aerosols; Author-Supplied Keyword: Mass concentration; Author-Supplied Keyword: Number concentration; Author-Supplied Keyword: Urban aerosols; NAICS/Industry Codes: 334512 Automatic Environmental Control Manufacturing for Residential, Commercial, and Appliance Use; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.scitotenv.2004.12.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Yadong
AU - Lu, Yongju
AU - Yuan, Bao-Zhu
AU - Castranova, Vince
AU - Shi, Xianglin
AU - Stauffer, John L
AU - Demers, Laurence M
AU - Chen, Fei
T1 - The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer.
JO - Oncogene
JF - Oncogene
Y1 - 2005/07/21/
VL - 24
IS - 31
M3 - Article
SP - 4873
EP - 4882
PB - Nature Publishing Group
SN - 09509232
AB - Environmental or occupational exposure to mineral dusts, mainly silica and asbestos, is associated with an increased incidence of lung inflammation, fibrosis, and/or cancer. To better understand the molecular events associated with these pulmonary diseases, we attempted to identify genes that are regulated by mineral dusts. Using a differential display reverse transcription polymerase chain reaction technique and mRNAs of alveolar macrophages from both normal individuals and coal miners, we identified a novel mineral dust-induced gene named mdig, which had not been fully characterized. The expression of mdig mRNA was detected in alveolar macrophages from coal miners but not from normal subjects. The inducible expression of mdig could be observed in A549 cells exposed to silica particles in a time-dependent manner. The full-length mdig mRNA was expressed in human lung cancer tissues but was barely detectable in the adjacent normal tissues. In addition, a number of lung cancer cell lines constitutively express mdig. Alternative spliced transcripts of mdig were detected in some lung cancer cell lines. Silencing mdig mRNA expression in A549 lung cancer cells by siRNA-mediated RNA interference inhibits cell proliferation and sensitizes the cells to silica-induced cytotoxicity. These results suggest that the mdig gene may be involved in the regulation of cell growth and possibly the development of cancer.Oncogene (2005) 24, 4873–4882. doi:10.1038/sj.onc.1208668; published online 9 May 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DUST
KW - GENETICS
KW - LUNGS -- Cancer
KW - GROWTH factors
KW - REVERSE transcriptase
KW - POLYMERASE chain reaction
KW - lung cancer
KW - mdig
KW - mineral dust
N1 - Accession Number: 17669939; Zhang, Yadong 1 Lu, Yongju 2 Yuan, Bao-Zhu 2 Castranova, Vince 2 Shi, Xianglin 2 Stauffer, John L 3 Demers, Laurence M 3 Chen, Fei 2; Email Address: LFD3@cdc.gov; Affiliation: 1: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Departemnt of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA; Source Info: 7/21/2005, Vol. 24 Issue 31, p4873; Subject Term: DUST; Subject Term: GENETICS; Subject Term: LUNGS -- Cancer; Subject Term: GROWTH factors; Subject Term: REVERSE transcriptase; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: lung cancer; Author-Supplied Keyword: mdig; Author-Supplied Keyword: mineral dust; Number of Pages: 10p; Document Type: Article
L3 - 10.1038/sj.onc.1208668
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hausner, Sven H.
AU - Striley, Cynthia A. F.
AU - Krause-Bauer, Jeanette A.
AU - Zimmer, Hans
T1 - Dibenzotetraaza Crown Ethers: A New Family of Crown Ethers Based on o.Phenylenedianijne.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2005/07/22/
VL - 70
IS - 15
M3 - Article
SP - 5804
EP - 5817
SN - 00223263
AB - Dibenzotetraaza (DBTA) crown ethers possess two α-phenylenediamine moieties. They are homologues of dibenso crown ether phase-transfer catalysts and were prepared from the condensation of benzimidazoles with oligo(ethyleneglycol) dichlorides and oligo(ethyleneglycol) ditosylates. Compounds with ring sizes ranging from 18-crown-6 to 42-crown-14 were prepared. In addition, various altered benzimidizoles were used to produce DBTA crown ethers with modified substituents and ether bridges, as well as benzimidazolidine crown ethers. The synthetic approach presented here proved to be a convenient route to a new family of crown ethers with overall yields of up to 48% based on the benzimidazole. Yields for the ring-closing step were generally high, ranging from 51% to 94%, without the need for high-dilution conditions. Reaction of the DBTA crown ethers with alkyl and benzyl halides was found to be a facile way to obtain the corresponding tetra-(N-organyl) compounds. Picrate extraction studies were carried out to determine phase-transfer catalytic capabilities. Extraction efficiencies for alkali-metal ions were lower than those for dibenzo-18-crown-6. Efficiencies were higher for other metal ions, with some selectivity for Pb2+. Tetra-(N-methyl) DBTA-18-crown-6 generally exhibited higher extraction efficiencies than its N-H analogue, but the selectivity was lower. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CROWN ethers
KW - CHEMICAL reactions
KW - MACROCYCLIC compounds
KW - CATALYSTS
KW - PHENYLENEDIAMINES
KW - ORGANIC chemistry
N1 - Accession Number: 17745308; Hausner, Sven H. 1,2; Email Address: shhausner@ucdavis.edu Striley, Cynthia A. F. 3 Krause-Bauer, Jeanette A. 1 Zimmer, Hans 1; Affiliation: 1: Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221 2: Department of Biomedical Engineering, University of California-Davis, One Shields Ave., Davis, CA 95616 3: Biomonitoring Section, National Institute of Occupational Safety and Health (NIOSH), Cincinnati, Ohio 45226; Source Info: 7/22/2005, Vol. 70 Issue 15, p5804; Subject Term: CROWN ethers; Subject Term: CHEMICAL reactions; Subject Term: MACROCYCLIC compounds; Subject Term: CATALYSTS; Subject Term: PHENYLENEDIAMINES; Subject Term: ORGANIC chemistry; Number of Pages: 14p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1021/jo050281z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Belluco, Claudio
AU - Mammano, Enzo
AU - Petricoin, Emanuel
AU - Prevedello, Luca
AU - Calvert, Valerie
AU - Liotta, Lance
AU - Nitti, Donato
AU - Lise, Mario
T1 - Kinase substrate protein microarray analysis of human colon cancer and hepatic metastasis
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 2005/07/24/
VL - 357
IS - 2
M3 - Article
SP - 180
EP - 183
SN - 00098981
AB - Abstract: Background: Liver metastases represent the major determinant of survival in patients with colorectal cancer (CRC). In cases with unresectable liver disease, more effective agents are needed, since chemotherapy achieves median survival of only 15 months. Protein kinases coordinate complex functions that are often disregulated in cancer and are therefore considered important targets for molecular therapeutics. In this study, we investigated the phosphoproteomic status of different protein kinases in primary CRC and in liver metastases. Methods: The status of 29 key endpoints was evaluated using reverse phase protein array on laser capture microdissected neoplastic cells from five primary CRCs without metastases, three patient-matched primary CRCs and synchronous liver metastases and five CRC metachronous liver metastases. Results: Unsupervised hierarchical two-way clustering analysis showed an entirely different phosphoproteomic profile in primary CRCs compared to liver metastases. This difference was observed also in primary and metastatic patient-matched lesions. Conclusions: Our findings of different signaling pathways between primary and metastatic CRC suggest a possible microenvironment effect, and emphasize the need to perform molecular network analysis of metastatic tissue when molecular targeting is considered. [Copyright &y& Elsevier]
AB - Copyright of Clinica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METASTASIS
KW - CANCER invasiveness
KW - BILIARY tract
KW - LIVER -- Cancer
KW - Colorectal cancer
KW - Metastasis
KW - Protein kinases
KW - Proteomics
N1 - Accession Number: 18094408; Belluco, Claudio 1; Email Address: claudio.belluco@unipd.it Mammano, Enzo 1 Petricoin, Emanuel 2 Prevedello, Luca 1 Calvert, Valerie 2 Liotta, Lance 3 Nitti, Donato 1 Lise, Mario 1; Affiliation: 1: Department of Oncological and Surgical Science, Surgery Branch, University of Padova, Padova, Italy 2: FDA-NCI Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 3: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA; Source Info: Jul2005, Vol. 357 Issue 2, p180; Subject Term: METASTASIS; Subject Term: CANCER invasiveness; Subject Term: BILIARY tract; Subject Term: LIVER -- Cancer; Author-Supplied Keyword: Colorectal cancer; Author-Supplied Keyword: Metastasis; Author-Supplied Keyword: Protein kinases; Author-Supplied Keyword: Proteomics; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.cccn.2005.03.024
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alarcon, Walter A.
AU - Calvert, Geoffrey M.
AU - Blondell, Jerome M.
AU - Mehler, Louise N.
AU - Sievert, Jennifer
AU - Propeck, Maria
AU - Tibbetts, Dorothy S.
AU - Becker, Alan
AU - Lackovic, Michelle
AU - Soileau, Shannon B.
AU - Das, Rupali
AU - Beckman, John
AU - Male, Dorilee P.
AU - Thomsen, Catherine L.
AU - Stanbury, Martha
T1 - Acute Illnesses Associated With Pesticide Exposure at Schools.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/07/27/
VL - 294
IS - 4
M3 - Article
SP - 455
EP - 465
SN - 00987484
AB - Context: Pesticides continue to be used on school property, and some schools are at risk of pesticide drift exposure from neighboring farms, which leads to pesticide exposure among students and school employees. However, information on the magnitude of illnesses and risk factors associated with these pesticide exposures is not available. Objective: To estimate the magnitude of and associated risk factors for pesticide-related illnesses at schools. Design, Setting, and Participants: Analysis of surveillance data from 1998 to 2002 of 2593 persons with acute pesticide-related illnesses associated with exposure at schools. Nationwide information on pesticide-related illnesses is routinely collected by 3 national pesticide surveillance systems: the National Institute for Occupational Safety and Health Sentinel Event Notification System for Occupational Risks pesticides program, the California Department of Pesticide Regulation, and the Toxic Exposure Surveillance System. Main Outcome Measures: Incidence rates and severity of acute pesticide-related illnesses. Results: Incidence rates for 1998-2002 were 7.4 cases per million children and 27.3 cases per million school employee full-time equivalents. The incidence rates among children increased significantly from 1998 to 2002. Illness of high severity was found in 3 cases (0.1%), moderate severity in 275 cases (11%), and low severity in 2315 cases (89%). Most illnesses were associated with insecticides (n = 895, 35%), disinfectants (n = 830, 32%), repellents (n = 335, 13%), or herbicides (n = 279, 11%). Among 406 cases with detailed information on the source of pesticide exposure, 281 (69%) were associated with pesticides used at schools and 125 (31%) were associated with pesticide drift exposure from farmland. Conclusions: Pesticide exposure at schools produces acute illnesses among school employees and students. To prevent pesticide-related illnesses at schools, implementation of integrated pest management programs in schools, practices to reduce pesticide drift, and adoption of pesticide spray buffer zones around schools are recommended. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - CHILDREN
KW - DISEASES
KW - EMPLOYEES
KW - PESTS -- Control
KW - POISONS
KW - SPRAYING & dusting in agriculture
KW - WEED control
KW - Child
KW - Environmental Exposure
KW - Pesticides
KW - Schools
N1 - Accession Number: 17742738; Alarcon, Walter A. 1 Calvert, Geoffrey M. 1 Blondell, Jerome M. 1 Mehler, Louise N. 1 Sievert, Jennifer 1 Propeck, Maria 1 Tibbetts, Dorothy S. 1 Becker, Alan 1 Lackovic, Michelle 1 Soileau, Shannon B. 1 Das, Rupali 1 Beckman, John 1 Male, Dorilee P. 1 Thomsen, Catherine L. 1 Stanbury, Martha 1; Affiliation: 1: National Institute for Occupational Safety and Health, US Centers for Disease Control and Prevention, Cincinnati, Ohio (Drs Alarcon and Calvert); Office of Pesticide Programs, US Environmental Protection Agency, Washington, DC (Dr Blondell); Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento (Dr Mehler); Environmental and Injury Epidemiology and Toxicology Branch, Texas Department of State Health Services, Austin (Mss Sievert and Propeck); Pesticides and Surveillance Section, Washington Department of Health, Olympia (Ms Tibbetts); Bureau of Community Environmental Health, Florida Department of Health, Tallahassee (Mr Becker); Section of Environmental Epidemiology and Toxicology, Louisiana Department of Health and Hospitals, New Orleans (Mss Lackovic and Soileau); Occupational Health Branch, California Department of Health Services, Oakland (Dr Das); Public Health Institute, Oakland, Calif (Mr Beckman); Bureau of Occupational Health, New York State Department of Health, Troy (Ms Male); Environmental and Occupational Epidemiology, Oregon Department of Human Services–Health Services, Portland (Ms Thomsen); and Division of Environmental and Occupational Epidemiology, Michigan Department of Community Health, Lansing (Ms Stanbury).; Source Info: 7/27/2005, Vol. 294 Issue 4, p455; Subject Term: PESTICIDES; Subject Term: CHILDREN; Subject Term: DISEASES; Subject Term: EMPLOYEES; Subject Term: PESTS -- Control; Subject Term: POISONS; Subject Term: SPRAYING & dusting in agriculture; Subject Term: WEED control; Author-Supplied Keyword: Child; Author-Supplied Keyword: Environmental Exposure; Author-Supplied Keyword: Pesticides; Author-Supplied Keyword: Schools; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 561730 Landscaping Services; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106531707
T1 - Acute illnesses associated with pesticide exposure at schools.
AU - Alarcon WA
AU - Calvert GM
AU - Blondell JM
AU - Mehler LN
AU - Sievert J
AU - Propeck M
AU - Tibbetts DS
AU - Becker A
AU - Lackovic M
AU - Soileau SB
AU - Das R
AU - Beckman J
AU - Male DP
AU - Thomsen CL
AU - Stanbury M
AU - Alarcon, Walter A
AU - Calvert, Geoffrey M
AU - Blondell, Jerome M
AU - Mehler, Louise N
AU - Sievert, Jennifer
Y1 - 2005/07/27/
N1 - Accession Number: 106531707. Language: English. Entry Date: 20051028. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the US government through the US Environmental Protection Agency and the Centers for Disease Control and Prevention. NLM UID: 7501160.
KW - Environmental Exposure -- Adverse Effects
KW - Occupational Diseases -- Epidemiology
KW - Pesticides -- Adverse Effects
KW - Poisoning -- Epidemiology
KW - Schools
KW - Adolescence
KW - Adult
KW - California
KW - Child
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Disease Surveillance
KW - Incidence
KW - Odds Ratio
KW - Regression
KW - Funding Source
KW - Human
SP - 455
EP - 465
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 294
IS - 4
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Pesticides continue to be used on school property, and some schools are at risk of pesticide drift exposure from neighboring farms, which leads to pesticide exposure among students and school employees. However, information on the magnitude of illnesses and risk factors associated with these pesticide exposures is not available.Objective: To estimate the magnitude of and associated risk factors for pesticide-related illnesses at schools.Design, Setting, and Participants: Analysis of surveillance data from 1998 to 2002 of 2593 persons with acute pesticide-related illnesses associated with exposure at schools. Nationwide information on pesticide-related illnesses is routinely collected by 3 national pesticide surveillance systems: the National Institute for Occupational Safety and Health's Sentinel Event Notification System for Occupational Risks pesticides program, the California Department of Pesticide Regulation, and the Toxic Exposure Surveillance System.Main Outcome Measures: Incidence rates and severity of acute pesticide-related illnesses.Results: Incidence rates for 1998-2002 were 7.4 cases per million children and 27.3 cases per million school employee full-time equivalents. The incidence rates among children increased significantly from 1998 to 2002. Illness of high severity was found in 3 cases (0.1%), moderate severity in 275 cases (11%), and low severity in 2315 cases (89%). Most illnesses were associated with insecticides (n = 895, 35%), disinfectants (n = 830, 32%), repellents (n = 335, 13%), or herbicides (n = 279, 11%). Among 406 cases with detailed information on the source of pesticide exposure, 281 (69%) were associated with pesticides used at schools and 125 (31%) were associated with pesticide drift exposure from farmland.Conclusions: Pesticide exposure at schools produces acute illnesses among school employees and students. To prevent pesticide-related illnesses at schools, implementation of integrated pest management programs in schools, practices to reduce pesticide drift, and adoption of pesticide spray buffer zones around schools are recommended.
SN - 0098-7484
AD - National Institute for Occupational Safety and Health, US Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA
U2 - PMID: 16046652.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106531707&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rentian Feng
AU - Yongju Lu
AU - Bowman, Linda L.
AU - Yong Qian
AU - Castranova, Vincent
AU - Min Ding
T1 - Inhibition of Activator Protein-1, NF-κB, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/07/29/
VL - 280
IS - 30
M3 - Article
SP - 27888
EP - 27895
SN - 00219258
AB - Chlorogenic acid, the ester of caffeic acid with quinic acid, is one of the most abundant polyphenols in the human diet. The antioxidant and anticarcinogenic properties of chlorogenic acid have been established in animal studies. However, little is known about the molecular mechanisms through which chlorogenic acid inhibits carcinogenesis. In this study, we found that chlorogenic acid inhibited the proliferation of A549 human cancer cells in vitro. The results of the soft agar assay indicated that chlorogenic acid suppressed 12-O-tetradecanoylphorbol-13-acetute (TPA)-induced neoplastic transformation of JB6 P+ cells in a dose-dependent manner. Pretreatment of JB6 cells with chlorogenic acid blocked UVB- or TPA-induced transactivation of AP-1 and NF-κB over the same dose range. At low concentrations, chlorogenic acid decreased the phosphorylation of c-Jun NH2-terminal kinases, p38 kinase, and MAPK kinase 4 induced by UVB/12-O-tetradecanoylphorbol-13-acetate, yet higher doses were required to inhibit extracellular signal-regulated kinases. Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase. Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity. The phosphatidylinositol 3-kinase pathway might be involved in the activation of Nrf2 translocation. These results provide the first evidence that chlorogenic acid could protect against environmental carcinogen-induced carcinogenesis and suggest that the chemopreventive effects of chlorogenic acid may be through its up-regulation of cellular antioxidant enzymes and suppression of ROS-mediated NF-κB, AP-1, and MAPK activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - ENZYMES
KW - CHLOROGENIC acid
KW - DEPSIDES
KW - ESTERS
KW - POLYPHENOLS
N1 - Accession Number: 17867678; Rentian Feng 1,2 Yongju Lu 1 Bowman, Linda L. 1 Yong Qian 1 Castranova, Vincent 1 Min Ding 1; Email Address: mid5@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Dept. of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace St., Pittsburgh, PA 15261; Source Info: 7/29/2005, Vol. 280 Issue 30, p27888; Subject Term: PROTEINS; Subject Term: ENZYMES; Subject Term: CHLOROGENIC acid; Subject Term: DEPSIDES; Subject Term: ESTERS; Subject Term: POLYPHENOLS; Number of Pages: 8p; Illustrations: 10 Graphs; Document Type: Article
L3 - 10.1074/jbc.M503347200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burr, Donald H.
AU - Rollins, David
AU - Lee, Lanfong H.
AU - Pattarini, Dawn L.
AU - Walz, Steven S.
AU - Tian, Jing-Hui
AU - Pace, John L.
AU - Bourgeois, A.L.
AU - Walker, Richard I.
T1 - Prevention of disease in ferrets fed an inactivated whole cell Campylobacter jejuni vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2005/07/29/
VL - 23
IS - 34
M3 - Article
SP - 4315
EP - 4321
SN - 0264410X
AB - Abstract: Ferrets were used to demonstrate the potential of a killed whole cell vaccine prepared from Campylobacter jejuni to protect against disease. C. jejuni strain 81–176 was grown in BHI broth, formalin-fixed, and resuspended in PBS to a concentration of 1010 cells per ml. This vaccine (CWC) or live organisms were delivered orally with a nasogastric tube into anesthetized animals treated to reduce gastric acidity and intestinal motility. When 5×1010 CFU of the vaccine strain (Lior serotype 5) or one of two other serotypes, CGL-7 (Lior 4) or BT44 (Lior 9), was used to challenge the ferrets, all of the animals developed a mucoid diarrhea. If the animals had been challenged with 5×109 CFU of the homologous strain 1 month before challenge with 1010 CFU, 80–100% protection against disease was seen. This protection was also obtained after an initial exposure to the 81–176 strain followed by challenge with either of the heterologous strains. CWC was used to see if protection demonstrated with the live organisms could be produced with the non-living preparation. When 109 cells of CWC was given as two doses 7 days apart with or without 25μg of a coadministered mucosal adjuvant, LTR192G, only 40–60% of the animals were protected. If the regimen was changed to four doses given 48h apart, 80% of the animals were free of diarrhea after subsequent challenge. Increasing the number of cells in the four dose regimen to 1010 cells did not improve protection. Animals given four doses of 1010 cells combined with LTR192G were subsequently challenged with 1010 cells of the homologous strain or the heterologous strain CGL-7. The CWC protected against both strains. Serum IgG antibody titers determined by ELISA showed little increase following the CWC four dose vaccination regimen, compared to animals given one dose of the live organism. On subsequent challenge, however, both CWC vaccinated and live-challenged ferrets showed comparable antibody titer increases above those obtained following the initial challenge or vaccination. Western blots were used to show that the immunodominant antigen in vaccinated animals was a 45kDa protein, while in ferrets challenged with live organisms the immunodominant antigen was a 62kDa protein. These data show that the CWC can be used to protect against disease caused by Campylobacter. They also show that protection and serum IgG responses do not depend upon the use of the mucosal adjuvant and that cross protection among some of the major serotypes of Campylobacter responsible for human disease is possible. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Campylobacter
KW - Campylobacter jejuni
KW - Cells
KW - Diarrhea
KW - Vaccine
N1 - Accession Number: 18127535; Burr, Donald H. 1; Rollins, David 2; Lee, Lanfong H. 2; Pattarini, Dawn L. 1; Walz, Steven S. 2; Tian, Jing-Hui 3; Pace, John L. 3; Bourgeois, A.L. 2; Walker, Richard I. 3; Email Address: walkerri@cber.fda.gov; Affiliations: 1: Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA; 2: Enteric Diseases Program, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910, USA; 3: Antex Biologics, 300 Professional Dr., Gaithersburg, MD 20879, USA; Issue Info: Jul2005, Vol. 23 Issue 34, p4315; Thesaurus Term: Diseases; Thesaurus Term: Campylobacter; Thesaurus Term: Campylobacter jejuni; Subject Term: Cells; Author-Supplied Keyword: Diarrhea; Author-Supplied Keyword: Vaccine; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.03.038
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Bar-Lev, Shirly
AU - Harrison, Michael I.
T1 - LOCALIZATION OF HEALTH IT: HOW USERS "REPAIR" ELECTRONIC MEDICAL RECORD SYSTEMS.
JO - Academy of Management Annual Meeting Proceedings
JF - Academy of Management Annual Meeting Proceedings
Y1 - 2005/08//
M3 - Proceeding
SP - E1
EP - E5
PB - Academy of Management
SN - 21516561
AB - Implementation of Health Information Technologies (HIT) in hospitals encounters difficulties and leads to unintended consequences when there is poor fit between the practices, standards, and assumptions of clinical work and those embedded within HIT. This paper explores ways in which nurses and physicians sought to "repair" an Electronic Medical Record (EMR) system and improve its fit with their everyday practice. The paper is based on a case study of the introduction of an EMR in an academic hospital in Israel. The research was guided by Orlikowski's work on the social construction of technology. We show that repair work by clinical practitioners flowed from pragmatic efforts to incorporate HIT into their practices, rather than from arbitrary resistance to HIT. By negotiating changes in the EMR, the practitioners succeeded in overcoming gaps between the designers' assumptions and realities of clinical work. In this way the EMR became localized. This study supports Orlikowski's argument that the features of a technology are not built in but emerge though negotiations among its stakeholders. Moreover, the study supports previous research findings showing that localization is inherent to implementation of new technologies. Moreover, we argue that localization of HIT implementation may actually contribute to its capacity to improve clinical work. Recognition of gaps between assumptions built into HIT software and the realities of clinical practice may help managers and designers learn to work more effectively with practitioners to develop HIT systems that are flexible and well aligned with the needs and concerns of users. [ABSTRACT FROM AUTHOR]
AB - Copyright of Academy of Management Annual Meeting Proceedings is the property of Academy of Management and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSES
KW - PHYSICIANS
KW - HOSPITALS
KW - MEDICAL records
KW - ELECTRONIC information resources
KW - CASE studies
KW - MEDICINE -- Practice
KW - ELECTRONIC systems
KW - ISRAEL
KW - health information technology
KW - hospitals
KW - innovation
N1 - Accession Number: 18778678; Bar-Lev, Shirly 1; Email Address: shirly.barlev@gmail.com; Harrison, Michael I. 2; Affiliations: 1: Department of Sociology and Anthropology, Bar-Ilan University, Ramat Gan, Israel; 2: Agency for Healthcare Research and Quality; Issue Info: 2005, pE1; Thesaurus Term: NURSES; Thesaurus Term: PHYSICIANS; Thesaurus Term: HOSPITALS; Subject Term: MEDICAL records; Subject Term: ELECTRONIC information resources; Subject Term: CASE studies; Subject Term: MEDICINE -- Practice; Subject Term: ELECTRONIC systems; Subject: ISRAEL; Author-Supplied Keyword: health information technology; Author-Supplied Keyword: hospitals; Author-Supplied Keyword: innovation; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 5p; Document Type: Proceeding
L3 - 10.5465/AMBPP.2005.18778678
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=18778678&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Ranney, Christine K.
AU - Sahn, David E.
AD - Agency for Healthcare Research and Quality, Rockville, MD
AD - Cornell U
AD - Cornell U
T1 - Consistent Estimation of Censored Demand Systems Using Panel Data
JO - American Journal of Agricultural Economics
JF - American Journal of Agricultural Economics
Y1 - 2005/08//
VL - 87
IS - 3
SP - 660
EP - 672
SN - 00029092
N1 - Accession Number: 0807224; Keywords: Elasticity; Estimation; Heterogeneity; Geographic Descriptors: Romania; Geographic Region: Europe; Publication Type: Journal Article; Update Code: 200512
N2 - We derive a joint continuous/censored commodity demand system for panel data applications. Unobserved heterogeneity is controlled for using a correlated random effects specification and a generalized method of moments framework used to estimate the model. While relatively small differences in elasticity estimates are found between a flexible random effects specification and one that restricts the random effect coefficient to be time invariant, larger differences are observed when comparing the flexible model to a pooled cross-sectional estimator. The results suggest the limited ability of such estimators to control for preference heterogeneity and unit-value endogeneity leads to parameter bias.
KW - Model Construction and Estimation C51
KW - Consumer Economics: Empirical Analysis D12
KW - Socialist Institutions and Their Transitions: Consumer Economics; Health; Education and Training: Welfare, Income, Wealth, and Poverty P36
L3 - http://ajae.oxfordjournals.org/content/by/year
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UR - http://ajae.oxfordjournals.org/content/by/year
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Steiner, Alexandre A.
AU - Chakravarty, Sumana
AU - Robbins, Jared R.
AU - Dragic, Alexander S.
AU - Pan, Jennifer
AU - Herkenham, Miles
AU - Romanovsky, Andrej A.
T1 - Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se—not by lipoprotein contaminants.
JO - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
JF - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
Y1 - 2005/08//
VL - 58
IS - 2
M3 - Article
SP - R348
EP - R352
SN - 03636119
AB - LPS preparations cause a variety of body temperature (Tb) responses: monophasic fever, different phases of polyphasic fever, and hypothermia. Conventional (c) LPS preparations contain highly active lipoprotein contaminants (endotoxin proteins). Whereas LPS signals predominantly via the Toll-like receptor (TLR) 4, endotoxin proteins signal via TLR2. Several TLR2-dependent responses of immunocytes to cLPS in vitro are triggered by endotoxin proteins and not by LPS itself. We tested whether any Tb response to cLPS from Escherichia coli 055:B5 is triggered by non-TLR4-signaling contaminants. A decontaminated (d) LPS preparation (free of endotoxin proteins) was produced by subjecting cLPS to phenol-water reextraction. The presence of nonTLR4-signaling contaminants in cLPS (and their absence in dLPS) was confirmed by showing that cLPS (but not dLPS) induced IL-1β expression in the spleen and increased serum levels of TNF-α and IL-1β of C3H/HeJ mice; these mice bear a nonfunctional TLR4. Yet, both cLPS and dLPS caused cytokine responses in C3H/HeOuJ mice; these mice bear a fully functional TLR4. We then studied the Tb responses to cLPS and dLPS in Wistar rats preimplanted with jugular catheters. At a neutral ambient temperature (30°C), a low (0.1 µg/kg iv) dose of cLPS caused a monophasic fever, whereas a moderate (10 µg/kg iv) dose produced a polyphasic fever. In the cold (20°C), a high (500 µg/kg iv) dose of cLPS caused hypothermia. All Tb responses to dLPS were identical to those of cLPS. We conclude that all known Tb responses to LPS preparations are triggered by LPS per se and not by non-TLR4-signaling contaminants of such preparations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Regulatory, Integrative & Comparative Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTOXINS
KW - BODY temperature
KW - LIPOPROTEINS
KW - ESCHERICHIA coli
KW - SPLEEN
KW - CYTOKINES
KW - body temperature
KW - fever
KW - hypothermia
KW - LPS
KW - TLR2
KW - TLR4
KW - Toll-like receptors
N1 - Accession Number: 17882319; Steiner, Alexandre A. 1 Chakravarty, Sumana 2 Robbins, Jared R. 1 Dragic, Alexander S. 1 Pan, Jennifer 1 Herkenham, Miles 2 Romanovsky, Andrej A. 1; Email Address: aromano@chw.edu; Affiliation: 1: Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 2: Section on Functional Neuroanatomy, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland; Source Info: Aug2005, Vol. 58 Issue 2, pR348; Subject Term: ENDOTOXINS; Subject Term: BODY temperature; Subject Term: LIPOPROTEINS; Subject Term: ESCHERICHIA coli; Subject Term: SPLEEN; Subject Term: CYTOKINES; Author-Supplied Keyword: body temperature; Author-Supplied Keyword: fever; Author-Supplied Keyword: hypothermia; Author-Supplied Keyword: LPS; Author-Supplied Keyword: TLR2; Author-Supplied Keyword: TLR4; Author-Supplied Keyword: Toll-like receptors; Number of Pages: 5p; Illustrations: 8 Graphs; Document Type: Article
L3 - 10.1152/ajpregu.00223.2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17882319&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nash, David A.
AU - Nagel, Ron J.
T1 - Confronting Oral Health Disparities Among American Indian/Alaska Native Children: The Pediatric Oral Health Therapist.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005/08//
VL - 95
IS - 8
M3 - Article
SP - 1325
EP - 1329
PB - American Public Health Association
SN - 00900036
AB - American Indian and Alaska Native (ALAN) children are disproportionately affected by oral disease compared with the general population of American children. Additionally, AIAN children have limited access to professional oral health care. The Indian Health Service (IHS) and AIAN tribal leaders face a significant problem in ensuring care for the oral health of these children. We discuss the development and deployment of a new allied oral health professional, a pediatric oral health therapist. This kind of practitioner can effectively extend the ability of dentists to provide for children not receiving care and help to confront the significant oral health disparities existing in AIAN children. Resolving oral health disparities and ensuring access to oral health care for American Indians and Alaska Natives is a moral issue--one of social justice. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - NATIVE American children
KW - DENTAL care
KW - CHILDREN -- Dental care
KW - ALASKA
KW - HEALTH—MEDICAL
N1 - Accession Number: 17783294; Nash, David A. 1; Email Address: danash@email.uky.edu Nagel, Ron J. 2,3; Affiliation: 1: University of Kentucky, College of Dentistry, Division of Pediatric Dentistry, Lexington 2: Indian Health Service, Clinical and Preventive Support Center, Alaska Area 3: Consultant, Alaska Native Tribal Health Consortium, Anchorage, Alaska; Source Info: Aug2005, Vol. 95 Issue 8, p1325; Subject Term: CHILDREN -- Health; Subject Term: NATIVE American children; Subject Term: DENTAL care; Subject Term: CHILDREN -- Dental care; Subject Term: ALASKA; Author-Supplied Keyword: HEALTH—MEDICAL; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4864
L3 - 10.2105/AJPH.2005.061796
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martina, Yuri
AU - Kurian, Sunil
AU - Cherqui, Stephanie
AU - Evanoff, Gabriel
AU - Wilson, Carolyn
AU - Salomon, Daniel R.
T1 - Pseudotyping of Porcine Endogenous Retrovirus by Xenotropic Murine Leukemia Virus in a Pig Islet Xenotransplantation Model.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2005/08//
VL - 5
IS - 8
M3 - Article
SP - 1837
EP - 1847
PB - Wiley-Blackwell
SN - 16006135
AB - The potential of porcine endogenous retrovirus (PERV) as a human pathogen, particularly as a public health risk, is a major concern for xenotransplantation. In vitro PERV transmission to human cells is well established. Evidence from human/pig hematopoietic chimeras in immunodeficient mice suggests PERV transmission from pig to human cells in vivo. However, recently Yang et al. demonstrated in such a model that PERV-C, a nonhuman-tropic class, could be transmitted via pseudotyping by xenotropic murine leukemia virus (X-MLV). We developed a mouse pig islet xenotransplant model, where pig and human cells are located in physically separate compartments, to directly assess PERV transmission from a functional pig xenograft. X-MLV efficiently pseudotypes all three classes of PERV, including PERV-A and -B that are known to productively infect human cell lines and PERV-C that is normally not infectious for human cells. Pseudotyping also extends PERV's natural tropism to nonpermissive, nonhuman primate cells. X-MLV is activated locally by the surgical procedure involved in the tissue transplants. Thus, the presence and activation of endogenous X-MLV in immunodeficient mice limits the clinical significance of previous reports of in vivo PERV transmission from pig tissues to human cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETROVIRUSES
KW - MOUSE leukemia viruses
KW - LEUKEMIA
KW - ISLANDS of Langerhans
KW - TRANSPLANTATION of organs, tissues, etc.
KW - Pig islets
KW - porcine endogenous retrovirus (PERV)
KW - pseudotyping
KW - xenotransplantation
KW - xenotropic MLV
N1 - Accession Number: 17519451; Martina, Yuri 1 Kurian, Sunil 1 Cherqui, Stephanie 1 Evanoff, Gabriel 1 Wilson, Carolyn 2 Salomon, Daniel R. 1; Email Address: dsalomon@scripps.edu; Affiliation: 1: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA 2: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Aug2005, Vol. 5 Issue 8, p1837; Subject Term: RETROVIRUSES; Subject Term: MOUSE leukemia viruses; Subject Term: LEUKEMIA; Subject Term: ISLANDS of Langerhans; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Author-Supplied Keyword: Pig islets; Author-Supplied Keyword: porcine endogenous retrovirus (PERV); Author-Supplied Keyword: pseudotyping; Author-Supplied Keyword: xenotransplantation; Author-Supplied Keyword: xenotropic MLV; Number of Pages: 11p; Illustrations: 2 Diagrams, 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2005.00978.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porter, Cynthia M.
AU - Bloom, Eda T.
T1 - Human CD4+CD25+ Regulatory T Cells Suppress Anti-Porcine Xenogeneic Responses.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2005/08//
VL - 5
IS - 8
M3 - Article
SP - 2052
EP - 2057
PB - Wiley-Blackwell
SN - 16006135
AB - Due to the shortage of human organs, xenotransplantation is being explored as an alternative to allotransplantation, but immune rejection remains a major hurdle to its implementation. We tested the ability of human CD4+CD25+ T cells (Treg cells) to suppress CD4+ T cell-mediated anti-porcine xenoresponses using in vitro assays. Human Treg cells were hyporesponsive to porcine cell stimulation and suppressed the proliferative response of CD4+CD25− T cells in a dose-dependent manner, and comparison of the allo- and xenoresponses indicated that more Treg cells might be required to suppress the xenogeneic response than the allogeneic response. Stimulation of CD4+CD25− T cells with porcine cells resulted in secretion of IFN-γ, TNF-α, IL-10, IL-6 and IL-2, and Treg cells suppressed the secretion of these cytokines, as well as the CD4+CD25− T-cell cytolytic response against porcine cells. These results suggest a potential role for Treg cells in promoting xenograft survival. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - CD4 antigen
KW - CD antigens
KW - IMMUNOLOGY
KW - TRANSPLANTATION of organs, tissues, etc.
KW - CD4+ T cells
KW - cellular rejection
KW - T regulatory cells
KW - tolerance
KW - xenotransplantation
N1 - Accession Number: 17519456; Porter, Cynthia M. 1; Email Address: porterc@cber.fda.gov Bloom, Eda T. 1; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Aug2005, Vol. 5 Issue 8, p2052; Subject Term: T cells; Subject Term: CD4 antigen; Subject Term: CD antigens; Subject Term: IMMUNOLOGY; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Author-Supplied Keyword: CD4+ T cells; Author-Supplied Keyword: cellular rejection; Author-Supplied Keyword: T regulatory cells; Author-Supplied Keyword: tolerance; Author-Supplied Keyword: xenotransplantation; Number of Pages: 6p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2005.00972.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
T1 - Effects of gyrase mutation on the growth kinetics of ciprofloxacin-resistant strains of Clostridium perfringens
JO - Anaerobe
JF - Anaerobe
Y1 - 2005/08//
VL - 11
IS - 4
M3 - Article
SP - 201
EP - 205
SN - 10759964
AB - Abstract: To investigate the effect of gyrA mutation on resistance of Clostridium perfringens to fluoroquinolones, a ciprofloxacin-resistant mutant was developed. The mutant had a single substitution in gyrA at position 87 (Asp to Tyr) and no additional mutations in gyrB, parC or parE. The MIC values of gatifloxacin and ciprofloxacin for this strain were 16 and 32-fold higher than those for the wild type, which were 0.125 and 0.250μg/mL, respectively. The resistant mutant grew equally well in the presence or absence of 5μg/mL of ciprofloxacin or 1μg/mL of gatifloxacin and grew to lower cell densities with up to 30μg/mL of ciprofloxacin or 5μg/mL of gatifloxacin. Higher concentrations of fluoroquinolones resulted in increases in the time required to reach the end of the exponential phase and in lower cell densities at the end. The efflux pump inhibitor reserpine did not affect susceptibility to fluoroquinolones. The substitution of Asp 87 to Tyr in gyrA may have protected C. perfringens from low concentrations of ciprofloxacin and gatifloxacin and enabled survival and growth at higher concentrations. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBIOTICS
KW - CIPROFLOXACIN
KW - CLOSTRIDIUM
KW - SEROTONIN antagonists
KW - Clostridium perfringens
KW - Fluoroquinolones
KW - Gyrase
KW - Mutation
KW - Resistance
N1 - Accession Number: 17827478; Rafii, Fatemeh; Email Address: frafii@nctr.fda.gov Park, Miseon 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 71602, USA; Source Info: Aug2005, Vol. 11 Issue 4, p201; Subject Term: ANTIBIOTICS; Subject Term: CIPROFLOXACIN; Subject Term: CLOSTRIDIUM; Subject Term: SEROTONIN antagonists; Author-Supplied Keyword: Clostridium perfringens; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Gyrase; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: Resistance; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.anaerobe.2005.01.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BEAMER, BRYAN R.
AU - SHULMAN, STANLEY
AU - MAYNARD, ANDREW
AU - WILLIAMS, DENA
AU - WATKINS, DANIEL
T1 - Evaluation of Misting Controls to Reduce Respirable Silica Exposure for Brick Cutting.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2005/08//
VL - 49
IS - 6
M3 - Article
SP - 503
EP - 510
SN - 00034878
AB - It is estimated that more than 1.7 million workers in the United States are potentially exposed to respirable crystalline silica, with a large percentage having been exposed to silica concentrations higher than the limits set by current standards and regulations. The purpose of this study is to characterize the use of water-misting engineering controls to reduce exposure to respirable crystalline silica for construction workers engaged in the task of brick cutting. Since data concerning the efficacy of engineering controls collected at worksites is often confounded by factors such as wind, worker skill level, the experiments were conducted in a laboratory environment. A completely enclosed testing chamber housed the brick-cutting saw. Respirable dust concentrations were measured using the Model 3321 Aerodynamic Particle Sizer®. Specifically, the laboratory experiment was designed to compare dust suppression through water misting using conventional freely flowing water techniques. Brass atomizing nozzles with three flow rates were used for making this comparison: low (5.0 ml s−1 or 4.8 gal h−1), medium (9.0 ml s−1 or 8.6 gal h−1) and high (18 ml s−1 or 17.3 gal h−1). The flow rate for freely flowing water, using manufacturer-supplied equipment, was 50 ml s−1 (48 gal h−1). The experiment consisted of five replications of five samples each (low-misting, medium-misting, high-misting, freely flowing water and no control). The order of sampling within each replicate was randomized. Estimates of dust reduction showed that low-misting nozzles reduced the respirable mass fraction of dust by about 63%, medium-misting nozzles by about 67%, high-misting nozzles by about 79% and freely flowing water by about 93%. Based on these results, it may be feasible to use misting to control respirable silica dust instead of freely flowing water. This strategy is of practical interest to the construction industry which must frequently limit the amount of water used on construction sites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silicon compounds
KW - Atomizers
KW - Noise pollution
KW - Environmental monitoring
KW - Construction industry -- Water-supply
KW - Nozzles
KW - Specifications
KW - Construction workers
KW - United States
KW - construction
KW - dust control
KW - masonry cutting
KW - misting
KW - silica
N1 - Accession Number: 20125683; BEAMER, BRYAN R. 1; Email Address: beamerb@uwstout.edu; SHULMAN, STANLEY 2; MAYNARD, ANDREW 2; WILLIAMS, DENA 3; WATKINS, DANIEL 2; Affiliations: 1: University of Wisconsin-Stout, PO Box 790, Menomonie, WI 54751, USA; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 5555 Ridge Avenue, Cincinnati, OH 45213, USA; 3: Division of Nutrition and Physical Activity, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Atlanta, GA 30341-3717, USA; Issue Info: Aug2005, Vol. 49 Issue 6, p503; Thesaurus Term: Silicon compounds; Thesaurus Term: Atomizers; Thesaurus Term: Noise pollution; Thesaurus Term: Environmental monitoring; Subject Term: Construction industry -- Water-supply; Subject Term: Nozzles; Subject Term: Specifications; Subject Term: Construction workers; Subject: United States; Author-Supplied Keyword: construction; Author-Supplied Keyword: dust control; Author-Supplied Keyword: masonry cutting; Author-Supplied Keyword: misting; Author-Supplied Keyword: silica; NAICS/Industry Codes: 541620 Environmental Consulting Services; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 326198 All other plastic product manufacturing; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mei011
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kardous, Chucri A.
AU - Willson, Robert D.
AU - Murphy, William J.
T1 - Noise dosimeter for monitoring exposure to impulse noise
JO - Applied Acoustics
JF - Applied Acoustics
Y1 - 2005/08//
VL - 66
IS - 8
M3 - Article
SP - 974
EP - 985
SN - 0003682X
AB - Abstract: Commercially available noise dosimeters do not perform properly in impulsive noise environments because they suffer from instrumentation limitations and lack metrics that characterize impulse noise. In this paper, a design concept is proposed for an impulse noise monitoring dosimeter that addresses the current dosimeter’s limited capabilities and describes the various parameters that can appropriately be used to measure and evaluate exposure to impulse noise. The design concept is based on the accurate acquisition and storage of the original impulse waveform. For data analysis (using MATLAB) and calculation of “impulse noise metrics,” National Institute for Occupational Safety and Health (NIOSH) used a prototype impulse noise dosimeter system that consisted of a Bruel&Kjaer 4136 microphone and a Panasonic Digital Audio Tape Recorder. The proposed instrument would enable collection of data for validation of presently defined and yet to be defined metrics quantifying noise-induced permanent threshold shifts (NIPTS) resulting from impulse/impact exposures. It will also enable occupational safety and health professionals to make accurate measurements of ultimately approved metrics. [Copyright &y& Elsevier]
AB - Copyright of Applied Acoustics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSIMETERS
KW - RADIATION dosimetry
KW - RADIOACTIVITY -- Instruments
KW - NOISE
KW - Impulse noise
KW - New design
KW - Noise dosimeter
N1 - Accession Number: 17812117; Kardous, Chucri A. 1; Email Address: cyk5@cdc.gov Willson, Robert D. 2 Murphy, William J. 1; Affiliation: 1: Hearing Loss Prevention Section, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, C27, Cincinnati, OH 45226, USA 2: National Institute for Occupational Safety and Health and Beta Associates, Cincinnati, OH, USA; Source Info: Aug2005, Vol. 66 Issue 8, p974; Subject Term: DOSIMETERS; Subject Term: RADIATION dosimetry; Subject Term: RADIOACTIVITY -- Instruments; Subject Term: NOISE; Author-Supplied Keyword: Impulse noise; Author-Supplied Keyword: New design; Author-Supplied Keyword: Noise dosimeter; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.apacoust.2004.11.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marti, Gerald E.
AU - Rawstron, Andy C.
AU - Ghia, Paolo
AU - Hillmen, Peter
AU - Houlston, Richard S.
AU - Kay, Neil
AU - Schleinitz, Thérèse A.
AU - Caporaso, Neil
T1 - Diagnostic criteria for monoclonal B-cell lymphocytosis.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2005/08//
VL - 130
IS - 3
M3 - Article
SP - 325
EP - 332
PB - Wiley-Blackwell
SN - 00071048
AB - Very low levels of circulating monoclonal B-cell subpopulations can now be detected in apparently healthy individuals using flow cytometry. We propose the term ‘monoclonal B-cell lymphocytosis’ (MBL) to describe this finding. The aim of this document is to provide a working definition of MBL for future clinical, epidemiological and laboratory studies. We propose that the detection of a monoclonal B-cell population by light chain restriction is sufficient to define this condition in individuals not meeting the diagnostic criteria for other B-lymphoproliferative disorders. The majority of individuals with MBL will have cells that are indistinguishable from chronic lymphocytic leukaemia (CLL). However, this blood cell clonal expansion of CD5+ or CD5− B-lymphocytes is age-dependent and immunophenotypic heterogeneity is common. Longitudinal studies are required to determine whether MBL is a precursor state to CLL or other B-lymphoproliferative disease in a situation analogous to a monoclonal gammopathy of undetermined significance and myeloma. Future studies of MBL should be directed towards determining its relationship to clinical disease, particularly in individuals from families with a genetic predisposition to developing CLL. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - CHRONIC lymphocytic leukemia
KW - LYMPHOPROLIFERATIVE disorders
KW - LYMPHOCYTIC leukemia
KW - LYMPHATIC diseases
KW - LEUCOCYTES
KW - early detection
KW - familial chronic lymphocytic leukaemia
KW - monoclonal B-cell lymphocytosis
KW - surrogate biomarker
N1 - Accession Number: 17672411; Marti, Gerald E. 1; Email Address: germarti@helix.nih.gov Rawstron, Andy C. 2 Ghia, Paolo 3 Hillmen, Peter 2 Houlston, Richard S. 4 Kay, Neil 5 Schleinitz, Thérèse A. 1,6 Caporaso, Neil 7; Affiliation: 1: Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, USA 2: Haematological Malignancy Diagnostic Service, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK 3: Department of Oncological Sciences, University of Torino and Laboratory of Cancer Immunology, Istituto per la Ricerca e la Cura del Cancro, Candiolo (TO), Italy 4: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK 5: Division of Hematology, Mayo Clinic, Rochester, MN, USA 6: Institut Paoli-Calmettes, Marseille Cedex9, France 7: Department of Medicine, Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA; Source Info: Aug2005, Vol. 130 Issue 3, p325; Subject Term: B cells; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: LYMPHOCYTIC leukemia; Subject Term: LYMPHATIC diseases; Subject Term: LEUCOCYTES; Author-Supplied Keyword: early detection; Author-Supplied Keyword: familial chronic lymphocytic leukaemia; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Author-Supplied Keyword: surrogate biomarker; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1365-2141.2005.05550.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Akpinar-Elci, Muge
AU - Stemple, Kimberly J.
AU - Enright, Paul L.
AU - Fahy, John V.
AU - Bledsoe, Toni A.
AU - Kreiss, Kathleen
AU - Weissman, David N.
T1 - Induced Sputum Evaluation in Microwave Popcorn Production Workers.
JO - CHEST
JF - CHEST
Y1 - 2005/08//
VL - 128
IS - 2
M3 - Article
SP - 991
EP - 997
SN - 00123692
AB - The article informs that the U.S. National Institute for Occupational Safety and Health recently reported on a microwave popcorn production plant where nine former workers showed severe fixed airways obstruction. Two of the former workers underwent biopsies and had findings compatible with bronchiolitis obliterans. Researchers measured airway inflammation by assessment of induced sputum obtained from workers in the microwave popcorn production plant. Induced sputum analysis is a reproducible, valid, and noninvasive method for studying airway inflammation. Use of induced sputum has been studied extensively in asthma and to a somewhat lesser degree in chronic obstructive pulmonary disease.
KW - INDUSTRIAL safety
KW - OCCUPATIONAL hazards
KW - LUNG diseases
KW - INFLAMMATION
KW - ASTHMA
KW - UNITED States
KW - airway inflammation
KW - bronchiolitis obliterans
KW - cytokines
KW - diacetyl
KW - flavoring
KW - occupation
N1 - Accession Number: 18064506; Akpinar-Elci, Muge 1; Email Address: melci@cdc.gov Stemple, Kimberly J. 2 Enright, Paul L. 1 Fahy, John V. 3 Bledsoe, Toni A. 4 Kreiss, Kathleen 1 Weissman, David N. 1; Affiliation: 1: Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Morgantown, WV. 2: National Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, MD. 3: Division of Pulmonary and Critical Care Medicine and Cardiovascular Research Institute, University of California, San Francisco CA. 4: Health Effects Laboratory Division, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Morgantown, WV.; Source Info: Aug2005, Vol. 128 Issue 2, p991; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL hazards; Subject Term: LUNG diseases; Subject Term: INFLAMMATION; Subject Term: ASTHMA; Subject Term: UNITED States; Author-Supplied Keyword: airway inflammation; Author-Supplied Keyword: bronchiolitis obliterans; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: diacetyl; Author-Supplied Keyword: flavoring; Author-Supplied Keyword: occupation; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106242666
T1 - Occupational and environmental lung disease. Induced sputum evaluation in microwave popcorn production workers.
AU - Akpinar-Elci M
AU - Stemple KJ
AU - Enright PL
AU - Fahy JV
AU - Bledsoe TA
AU - Kreiss K
AU - Weissman DN
A2 - Banks DE
Y1 - 2005/08//
N1 - Accession Number: 106242666. Language: English. Entry Date: 20070302. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0231335.
KW - Airway Obstruction -- Diagnosis
KW - Bronchiolitis Obliterans -- Diagnosis
KW - Cooking
KW - Microwaves
KW - Occupational Diseases -- Diagnosis
KW - Occupational Exposure
KW - Sputum -- Analysis
KW - Adult
KW - California
KW - Corn
KW - Data Analysis Software
KW - Eosinophils -- Analysis
KW - Female
KW - Interleukins -- Analysis
KW - Interviews
KW - Male
KW - Mann-Whitney U Test
KW - Mantel-Haenszel Test
KW - Spirometry
KW - Human
SP - 991
EP - 997
JO - CHEST
JF - CHEST
JA - CHEST
VL - 128
IS - 2
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - OBJECTIVE: Severe airways obstruction and bronchiolitis obliterans have been reported in microwave popcorn production workers and attributed to inhalation of flavoring agents. We investigated whether exposure to flavoring agents is associated with airways inflammation in popcorn production workers. METHODS: Fifty-nine workers with high exposures and 22 patients with low exposures to flavoring vapors completed a questionnaire, spirometry, and sputum induction. Sputum cell counts were categorized as 'high' if greater than (and 'low' if less than or equal to) the median cell counts of a healthy external control group (n = 24). We compared high- and low-exposure groups as well as all workers with control subjects. RESULTS: Neutrophil concentrations in nonsmoking workers were significantly higher than those of the healthy nonsmoking control group (p < 0.05). The smoking-adjusted odds ratio for high neutrophil count (> 1.63 x 10(5)/mL) was 3.8 (95% confidence interval, 1.3 to 11.5) in the high-exposure group compared with the low-exposure group. Sputum interleukin-8 and eosinophil cationic protein levels were higher in high-exposure workers than in low-exposure workers (p < 0.05). For the worker group, mean values of FEV1 percentage of predicted and FEV1/FVC percentage of predicted were > 95%. There were no relationships between sputum characteristics and the presence of airways obstruction. CONCLUSIONS: High exposure to popcorn flavoring agents is associated with neutrophilic airway inflammation in popcorn production workers. These data provide further evidence that popcorn production workers face a significant occupational hazard through exposure to flavoring agents.
SN - 0012-3692
AD - Division of Respiratory Diseases Studies, Field Studies Branch, Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Mail Stop H-2800, 1095 Willowdale Road, Morgantown, WV 26505; melci@cdc.gov
U2 - PMID: 16100197.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Finlay, W. J. J.
AU - deVore, N. C.
AU - Dobrovolskaia, E. N.
AU - Gam, A.
AU - Goodyear, C. S.
AU - Slater, J. E.
T1 - Exploiting the avian immunoglobulin system to simplify the generation of recombinant antibodies to allergenic proteins.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2005/08//
VL - 35
IS - 8
M3 - Article
SP - 1040
EP - 1048
PB - Wiley-Blackwell
SN - 09547894
AB - Monoclonal antibodies are a valuable tool in the study of allergens, but the technology used in their generation can be slow and labour-intensive. Therefore, we have examined recombinant antibody development by phage-display against single allergens and protein mixtures. We used the avian immunoglobulin system (generated from single VH and VL genes) to provide a rapid method for generating highly specific recombinant antibody fragments from a minimal number of animals. A single-chain antibody fragment (scFv) library was generated from a single chicken immunized with model allergens. ScFvs were isolated by phage-display and their properties investigated by ELISA and Western blot. Mono-specific scFvs were generated against recombinant Fel d 1 and native Amb a 1. Pannings against yellow jacket venom extracts only yielded clones that reacted with multiple proteins in the venom extract. The scFvs from each panning type were effectively expressed in Escherichia coli and readily purified. Highly specific and sensitive recognition of Fel d 1 and Amb a 1 was demonstrated in ELISA, with scFvs displaying antibody-concentration-dependent absorbance curves down to picogram levels of antibody. The specificity of selected antibodies for their cognate antigen was further confirmed in Western blot analysis, with scFvs directed to either Fel d 1 or Amb a 1 showing no reactivity for the other antigens used in immunization. Anti-Amb a 1 scFvs also mapped Amb a 1-isoform location in Western blot of ragweed extracts separated by 2D SDS-PAGE. DNA sequence analysis of scFvs showed that multiple different clones had been generated against Fel d 1 and Amb a 1. Using two anti-Fel d 1 scFv for ELISA analysis of Fel d 1 content in crude cat pelt extracts, we could produce data which were highly similar ( P=0.33 and 0.89 by paired t-test analysis) to those obtained using conventional assays (radial immunodiffusion). Phage-display technology may generate multiple allergen-specific recombinant antibody fragments from a single chicken, to allergens from mammalian, plant and insect sources. The resulting antibody fragments are of demonstrable use in allergen identification and quantification, in comparison with standard immunoassays. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Immunity
KW - Antigens
KW - Recombinant antibodies
KW - Immunoglobulins
KW - Genes
KW - 2D SDS-PAGE
KW - chicken
KW - ELISA
KW - phage display
KW - scFv
KW - Western blot
N1 - Accession Number: 18008591; Finlay, W. J. J. 1; deVore, N. C. 1; Dobrovolskaia, E. N. 1; Gam, A. 1; Goodyear, C. S. 2; Slater, J. E. 1; Email Address: SlateriJ@cber.fda.gov; Affiliations: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA.; 2: School of Medicine, University of California, San Diego, CA, USA.; Issue Info: Aug2005, Vol. 35 Issue 8, p1040; Thesaurus Term: Allergens; Thesaurus Term: Immunity; Thesaurus Term: Antigens; Subject Term: Recombinant antibodies; Subject Term: Immunoglobulins; Subject Term: Genes; Author-Supplied Keyword: 2D SDS-PAGE; Author-Supplied Keyword: chicken; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: phage display; Author-Supplied Keyword: scFv; Author-Supplied Keyword: Western blot; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1365-2222.2005.02307.x
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Kraus, Carl N.
AU - Zalkikar, Jyoti
AU - Powers, John H.
T1 - Levofloxacin and Macrolides for Treatment of Legionnaires Disease: Multiple Comparisons Give Few Answers.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/08//8/1/2005
VL - 41
IS - 3
M3 - Letter
SP - 416
EP - 416
SN - 10584838
AB - Presents a letter to the editor in response to the article "Levofloxacin and Macrolides for Treatment of Legionnaires Disease: Multiple Comparisons Give Few Answers," by Rosa M.ª Blázquez Garrido and others in one of the previous issues of the journal "Clinical Infectious Diseases."
KW - Letters to the editor
KW - Legionnaires' disease
N1 - Accession Number: 17528871; Kraus, Carl N. 1; Zalkikar, Jyoti 1; Powers, John H. 1; Email Address: POWERSJOH@cder.fda.gov; Affiliations: 1: Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; Issue Info: 8/1/2005, Vol. 41 Issue 3, p416; Subject Term: Letters to the editor; Subject Term: Legionnaires' disease; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tomkinson, A.
AU - De Martin, S.
AU - Gilchrist, C. R.
AU - Temple, M.
T1 - Instrumentation and patient characteristics that influence postoperative haemorrhage rates following tonsil and adenoid surgery.
JO - Clinical Otolaryngology
JF - Clinical Otolaryngology
Y1 - 2005/08//
VL - 30
IS - 4
M3 - Article
SP - 338
EP - 346
PB - Wiley-Blackwell
SN - 17494478
AB - Clin. Otolaryngol. 2005, 30, 338–346 To investigate the effect of the type instrumentation used and the age and gender characteristics of patients on postoperative haemorrhage rates following tonsil and adenoid surgery. A retrospective analysis of 13 593 procedures was performed from The Patient Episode Database for Wales between 1 January 1999 and 31 March 2004. National health policy changes created four periods of different instrument usage (reusable, single-use with diathermy, single-use alone, specified single-use with diathermy). These and the age and gender distribution of the patients were examined against four categories of postoperative haemorrhage. Postoperative haemorrhage rates were expressed as the number of complications per operations performed. Primary postoperative haemorrhage that occurred during the initial admission either required a return to theatre [R1] or was managed conservatively [N1]; secondary postoperative haemorrhage that required a return to hospital either returned to theatre [R2] or was managed conservatively [N2], were compared. Primary haemorrhage with return to theatre doubled, from the baseline rate with reusable instruments, from 0.6% (CI 0.5–0.8) to 1.2% (CI 0.7–1.9) when single-use instruments were introduced and remained high at 1.4% (CI 0.9–2.1) after the withdrawal of single-use diathermy. This haemorrhage rate returned to the baseline rate (0.6% CI 0.3–1.0) when specified single-use instruments were introduced. None of the other haemorrhage rates changed significantly throughout the four observation periods. Adenotonsillectomy and tonsillectomy patients have different age and gender patterns. In a univariate analysis, males over the age of 12 years were twice as likely to have haemorrhage with return to theatre than girls of the same age, 3.8% (CI 3.0–4.7) versus 1.7% (CI 1.4–2.1). A significant rise in serious postoperative primary haemorrhage but not secondary haemorrhage was seen following the initial introduction of single-use instruments that reverted to baseline with the introduction of specified single-use instruments. Diathermy does not appear to have affected the haemorrhage rates. There is a distinct age and gender pattern for tonsil and adenoid surgery and risk of postoperative haemorrhage. The use of arbitrary divisions of age may be misleading in studies that examine post-tonsillectomy haemorrhage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Otolaryngology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMORRHAGE
KW - POSTOPERATIVE pain
KW - ADENOIDS -- Surgery
KW - TONSILLECTOMY
KW - SURGICAL complications
KW - PATIENT monitoring
KW - CRITICAL care medicine
N1 - Accession Number: 17611149; Tomkinson, A. 1; Email Address: alun.tomkinson@cardiffandvale.wales.nhs.uk De Martin, S. 2 Gilchrist, C. R. 1 Temple, M. 2; Affiliation: 1: Department of Otolaryngology, Head and Neck Surgery, University Hospital Wales, Cardiff, UK 2: National Public Health Service for Wales, Temple of Peace and Health, Cardiff, UK; Source Info: Aug2005, Vol. 30 Issue 4, p338; Subject Term: HEMORRHAGE; Subject Term: POSTOPERATIVE pain; Subject Term: ADENOIDS -- Surgery; Subject Term: TONSILLECTOMY; Subject Term: SURGICAL complications; Subject Term: PATIENT monitoring; Subject Term: CRITICAL care medicine; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1365-2273.2005.01045.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17611149&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Catz, Diana S.
AU - Green, Nancy S.
AU - Tobin, Jonathan N.
AU - Lloyd-Puryear, Michele A.
AU - Kyler, Penny
AU - Umemoto, Ann
AU - Cernoch, Jennifer
AU - Brown, Roxane
AU - Wolman, Fredericka
T1 - Attitudes about Genetics in Underserved, Culturally Diverse Populations.
JO - Community Genetics
JF - Community Genetics
Y1 - 2005/08//
VL - 8
IS - 3
M3 - Article
SP - 161
EP - 172
SN - 14222795
AB - Objective: New medical discoveries regarding genetic susceptibility to common chronic diseases, and the decoding of the human genome have increased public attention to genetics. What information is understood and what attitudes exist towards genetics and genetic research have not been well examined in underserved, culturally diverse communities. Methods: To better understand attitudes and beliefs towards genetics and genetic testing in these groups, we conducted eight focus groups with 55 patients and health care workers in New York City and Westchester, N.Y., in English, Spanish, and Chinese. Results: Focus group participants had limited understanding about genetics or genetic testing. Newborn screening was the least-known genetic issue, even among health care workers. Regardless of their cultural group, most participants expressed a desire for more information about genetics and genetic tests. Latinos and Chinese participants generally expressed positive attitudes towards genetic studies and genetic testing, with the possibility of preventing diseases cited as the main advantage. Black Americans and Non-Hispanic Whites reported mixed feelings about genetic research and genetic testing. Concerns expressed included: anxiety before receiving test results or waiting for a disease to develop, fear of genetic discrimination by health and life insurance companies and employers, not having the financial means to deal with genetic diseases in themselves or a sick child, concern that children and adults are having too many tests. Black Americans expressed the most concern for possibly harmful use of genetic information. Conclusions: Minority populations of diverse cultures have limited knowledge about genetics and genetic testing, would like to have more information, and are not well reached by the current educational approaches. Participants knew the least about newborn screening, a test that is mandatory in the New York State. While genetic knowledge by minority populations was perhaps not different from the level of knowledge of consumers in general, minority populations are at particular risk of being left behind because of historically poor access to information and services. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETICS
KW - CHRONIC diseases
KW - GENOMES
KW - HEREDITY
KW - MINORITIES
KW - HUMAN chromosome abnormalities -- Diagnosis
KW - Attitudes
KW - Consumers
KW - Genetics
KW - Minority
N1 - Accession Number: 19891321; Catz, Diana S. 1 Green, Nancy S. 2; Email Address: ngreen@modimes.org Tobin, Jonathan N. 1 Lloyd-Puryear, Michele A. 3 Kyler, Penny 3 Umemoto, Ann 2 Cernoch, Jennifer 4 Brown, Roxane 5 Wolman, Fredericka 2; Affiliation: 1: Clinical Directors Network, Inc., New York, N.Y., USA 2: March of Dimes Birth Defects Foundation, National Office, White Plains, N.Y., USA 3: Genetic Services Branch, Children with Special Health Care Needs, Maternal Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Md., USA 4: Family Voices, National Office, Albuquerque, N. Mex., USA 5: Genetic Alliance, National Office, Washington, D.C. , USA; Source Info: 2005, Vol. 8 Issue 3, p161; Subject Term: GENETICS; Subject Term: CHRONIC diseases; Subject Term: GENOMES; Subject Term: HEREDITY; Subject Term: MINORITIES; Subject Term: HUMAN chromosome abnormalities -- Diagnosis; Author-Supplied Keyword: Attitudes; Author-Supplied Keyword: Consumers; Author-Supplied Keyword: Genetics; Author-Supplied Keyword: Minority; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1159/000086759
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Depree, G. J.
AU - Bledsoe, T. A.
AU - Siegel, P. D.
T1 - Survey of sulfur-containing rubber accelerator levels in latex and nitrile exam gloves.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 2005/08//
VL - 53
IS - 2
M3 - Article
SP - 107
EP - 113
PB - Wiley-Blackwell
SN - 01051873
AB - 2-Mercaptobenzothiazole and zinc dialkyldithiocarbamates are commonly used sulfur-containing rubber vulcanization accelerators known to cause allergic contact dermatitis. Exposure to these agents occurs through clothing such as undergarments and shoes, latex medical devices and latex and nitrile gloves. A simple, inexpensive screening method for total sulfur accelerator and a high performance liquid chromatographic speciation method were developed in the present study. These methods were applied to screen and quantify the sulfur accelerator content from 38 brands of ‘off-the-shelf’ latex and nitrile gloves obtained from commercial vendors. It was found that accelerator levels ranged from not detectable to 7.35 mg/g in the gloves analysed. Brands were found to contain single and multiple accelerator species within the glove. Powdered gloves had significantly higher accelerator levels than powder-free gloves from the same manufacturer; however, these chemical accelerators do not preferentially partition to the powder. The present analytical methodology is suitable for both manufacturing quality validation purposes, as well as for accelerator allergy research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT dermatitis
KW - ALLERGY
KW - GLOVES
KW - LATEX
KW - NITRILES
KW - SULFUR
KW - VULCANIZATION
KW - SKIN -- Inflammation
KW - allergic contact dermatitis
KW - exposure analysis
KW - rubber chemicals
N1 - Accession Number: 17638289; Depree, G. J. 1 Bledsoe, T. A. 1 Siegel, P. D. 1; Email Address: psiegel@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA.; Source Info: Aug2005, Vol. 53 Issue 2, p107; Subject Term: CONTACT dermatitis; Subject Term: ALLERGY; Subject Term: GLOVES; Subject Term: LATEX; Subject Term: NITRILES; Subject Term: SULFUR; Subject Term: VULCANIZATION; Subject Term: SKIN -- Inflammation; Author-Supplied Keyword: allergic contact dermatitis; Author-Supplied Keyword: exposure analysis; Author-Supplied Keyword: rubber chemicals; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.0105-1873.2005.00657.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Larrañaga, I.
AU - Arteagoitia, J. M.
AU - Rodriguez, J. L.
AU - Gonzalez, F.
AU - Esnaola, S.
AU - Piniés, J. A.
T1 - Socio-economic inequalities in the prevalence of Type 2 diabetes, cardiovascular risk factors and chronic diabetic complications in the Basque Country, Spain.
JO - Diabetic Medicine
JF - Diabetic Medicine
Y1 - 2005/08//
VL - 22
IS - 8
M3 - Article
SP - 1047
EP - 1053
PB - Wiley-Blackwell
SN - 07423071
AB - To establish the relationship between socio-economic status and the prevalence of known Type 2 diabetes, cardiovascular risk factors and chronic diabetic complications. In 2000, a cross-sectional survey was conducted among 61 general practitioners (GPs) who studied 65 651 people older than 24 years. Of those, 2985 known Type 2 diabetic patients were registered. The main outcome measures were: diabetes prevalence, major cardiovascular risk factors, chronic diabetic complications and primary care services utilization in Type 2 diabetic patients. Socio-economic status was based on area-based socio-economic measures. The prevalence of known Type 2 diabetes was higher in patients of lower socio-economic status (OR: 2.17, 95% CI: 1.77–2.28), especially among women (OR: 2.28, 95% CI: 1.91–2.73). In Type 2 diabetes patients, obesity, sedentary lifestyle, and abnormal levels of low-density lipoprotein (LDL) cholesterol and HbA1c were more prevalent among those from lower socio-economic status. Macroangiopathy was inversely associated with socio-economic status after adjustment for clinical and demographic variables. Patients of lower socio-economic status more frequently visited primary care services than those of higher status. This study shows an association between deprivation and Type 2 diabetes prevalence, cardiovascular risk factors and chronic diabetic complications in Type 2 diabetes patients. Despite a greater use of health services by less wealthy patients, they showed worse glycaemic control and more chronic complications. Besides clinical variables, socio-economic status and environmental information need to be considered in the assessment of risk profile of diabetic patients by health professionals and by health service planners. Diabet. Med. 22, 1047–1053 (2005) [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetic Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-insulin-dependent diabetes
KW - DIABETES
KW - SOCIAL status
KW - DIABETES -- Complications
KW - DISEASES -- Risk factors
KW - CARDIOVASCULAR diseases
KW - LOW density lipoproteins
KW - chronic complications
KW - health services use
KW - risk factors
KW - socioeconomic inequalities
KW - Type 2 diabetes
N1 - Accession Number: 17588454; Larrañaga, I. 1; Email Address: ilarranaga@ej-gv.es Arteagoitia, J. M. 1 Rodriguez, J. L. 1 Gonzalez, F. 1 Esnaola, S. 2 Piniés, J. A. 3; Affiliation: 1: Epidemiology Unit, Public Health Service, Basque Government, Vitoria-Gasteiz 2: Studies and Research Service. Department of Health, Basque Government 3: Endocrinology and Metabolism Department, Cruces Hospital, Osakidetza-Basque Health Service, Baracaldo; Source Info: Aug2005, Vol. 22 Issue 8, p1047; Subject Term: NON-insulin-dependent diabetes; Subject Term: DIABETES; Subject Term: SOCIAL status; Subject Term: DIABETES -- Complications; Subject Term: DISEASES -- Risk factors; Subject Term: CARDIOVASCULAR diseases; Subject Term: LOW density lipoproteins; Author-Supplied Keyword: chronic complications; Author-Supplied Keyword: health services use; Author-Supplied Keyword: risk factors; Author-Supplied Keyword: socioeconomic inequalities; Author-Supplied Keyword: Type 2 diabetes; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1464-5491.2005.01598.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17588454&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106520157
T1 - Socio-economic inequalities in the prevalence of type 2 diabetes, cardiovascular risk factors and chronic diabetic complications in the Basque Country, Spain.
AU - Larrañaga I
AU - Arteagoitia JM
AU - Rodriguez JL
AU - Gonzalez F
AU - Esnaola S
AU - Piniés JA
Y1 - 2005/08//
N1 - Accession Number: 106520157. Corporate Author: Sentinel Practice Network of the Basque Country. Language: English. Entry Date: 20050930. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8500858.
KW - Cardiovascular Risk Factors -- Epidemiology
KW - Diabetes Mellitus, Type 2 -- Epidemiology
KW - Socioeconomic Factors
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Diabetes Mellitus -- Risk Factors
KW - Female
KW - Health Services -- Utilization
KW - Hemoglobin A, Glycosylated
KW - Life Style, Sedentary
KW - Lipoproteins, LDL
KW - Logistic Regression
KW - Male
KW - Obesity
KW - Odds Ratio
KW - Smoking
KW - Spain
KW - Human
SP - 1047
EP - 1053
JO - Diabetic Medicine
JF - Diabetic Medicine
JA - DIABETIC MED
VL - 22
IS - 8
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - AIMS: To establish the relationship between socio-economic status and the prevalence of known Type 2 diabetes, cardiovascular risk factors and chronic diabetic complications. METHODS: In 2000, a cross-sectional survey was conducted among 61 general practitioners (GPs) who studied 65 651 people older than 24 years. Of those, 2985 known Type 2 diabetic patients were registered. The main outcome measures were: diabetes prevalence, major cardiovascular risk factors, chronic diabetic complications and primary care services utilization in Type 2 diabetic patients. Socio-economic status was based on area-based socio-economic measures. RESULTS: The prevalence of known Type 2 diabetes was higher in patients of lower socio-economic status (OR: 2.17, 95% CI: 1.77-2.28), especially among women (OR: 2.28, 95% CI: 1.91-2.73). In Type 2 diabetes patients, obesity, sedentary lifestyle, and abnormal levels of low-density lipoprotein (LDL) cholesterol and HbA(1c) were more prevalent among those from lower socio-economic status. Macroangiopathy was inversely associated with socio-economic status after adjustment for clinical and demographic variables. Patients of lower socio-economic status more frequently visited primary care services than those of higher status. CONCLUSIONS: This study shows an association between deprivation and Type 2 diabetes prevalence, cardiovascular risk factors and chronic diabetic complications in Type 2 diabetes patients. Despite a greater use of health services by less wealthy patients, they showed worse glycaemic control and more chronic complications. Besides clinical variables, socio-economic status and environmental information need to be considered in the assessment of risk profile of diabetic patients by health professionals and by health service planners.
SN - 0742-3071
AD - Epidemiology Unit, Public Health Service, Basque Government, Vitoria-Gasteiz; llarranaga@ej-gv.es
U2 - PMID: 16026371.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106520206
T1 - Nurse case manager effectiveness and case load in a large clinical practice: implications for workforce development.
AU - Wilson C
AU - Curtis J
AU - Lipke S
AU - Bochenski C
AU - Gilliland S
Y1 - 2005/08//
N1 - Accession Number: 106520206. Language: English. Entry Date: 20050930. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Special Diabetes Programs for Indians Grant no. 5H1D9400171-06. NLM UID: 8500858.
KW - Case Management -- Evaluation
KW - Workforce
KW - Confidence Intervals
KW - Diabetes Mellitus
KW - Funding Source
KW - Native Americans
KW - Nursing Care
KW - Odds Ratio
KW - Outcomes (Health Care)
KW - Retrospective Design
KW - Human
SP - 1116
EP - 1120
JO - Diabetic Medicine
JF - Diabetic Medicine
JA - DIABETIC MED
VL - 22
IS - 8
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - AIMS: Description of nurse case management experiences across different settings and patient populations is needed to define critical elements of the intervention and to help develop a workforce capable of responding to the growing diabetic population. METHODS: In a clinic providing services to American Indian and Alaska Native people, a retrospective cohort design was used to assess outcomes of patients who did and did not receive case management services and to quantify the case load of a team of four nurse case managers. RESULTS: Patients with nurse case managers were more likely to have an eye examination [OR 2.9, 95% CI (2.1, 3.8)], diet and exercise instruction by a registered dietitian [OR 2.8, 95% CI (1.9, 4.1)], self monitor blood glucose [OR 2.1, 95% CI (1.5, 3.1)], dental examination [OR 1.7, 95% CI (1.3, 2.3)], foot examination [OR 1.6, 95% CI (1.2, 2.1)], and nephropathy screening [OR 1.6, 95% CI (1.2, 2.1)]. After adjustment for type of treatment, initial HbA(1c), and diet instruction by a registered dietitian, the change in HbA(1c) remained significantly greater among those patients with a case manager than in those without (-0.52 units with vs. -0.17 units without, P < 0.006). The case load used to achieve this outcome averaged one nurse case manager per 365 patients. CONCLUSIONS: In this setting, a case management team comprised of four nurses with varying degrees of clinical experience was effective in improving adherence with diabetes services and had a favourable effect on short-term glucose control trends.
SN - 0742-3071
AD - Division of Centers of Excellence, Phoenix Indian Medical Center, 4212 N. 16th Street, Phoenix, AZ 85016; charlton.wilson@ihs.gov
U2 - PMID: 16026383.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106520206&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Martinez-Urtaza, Jaime
AU - Simental, Lourdes
AU - Velasco, David
AU - DePaola, Angelo
AU - lshibashi, Masanori
AU - Nakaguchi, Yoshitsugu
AU - Nishibuchi, Mitsuaki
AU - Carrera-Flores, Dolores
AU - Rey-Alvarez, Carmen
AU - Pousa, Anxela
T1 - Pandemic Vibrio parahaemolyticus O3:K6, Europe.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2005/08//
VL - 11
IS - 8
M3 - Letter
SP - 1319
EP - 1320
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Presents a letter to the editor about Vibrio parahaemolyticus.
KW - Letters to the editor
KW - Vibrio parahaemolyticus
N1 - Accession Number: 17798239; Martinez-Urtaza, Jaime 1; Email Address: ucmjmur@usc.es; Simental, Lourdes 1; Velasco, David 2; DePaola, Angelo 3; lshibashi, Masanori 4; Nakaguchi, Yoshitsugu 5; Nishibuchi, Mitsuaki 5; Carrera-Flores, Dolores 6; Rey-Alvarez, Carmen 6; Pousa, Anxela 6; Affiliations: 1: Universidad de Santiago de Compostela, Santiago de Compostela, Spain; 2: Complexo Hospitalario Universitario Juan Canalejo, A Coruña, Spain; 3: US Food and Drug Administration, Dauphin Island, Alabama, USA; 4: Osaka Prefectural Institute of Public Health, Osaka, Japan; 5: Kyoto University, Kyoto, Japan; 6: Consellería de Sanidade, Santiago de Compostela, Spain; Issue Info: Aug2005, Vol. 11 Issue 8, p1319; Subject Term: Letters to the editor; Subject Term: Vibrio parahaemolyticus; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Roubinian, Nareg
AU - Kirkpatrick, Beth D.
AU - Lynn, Freyja
AU - Zenilman, Jonathan
AU - Bash, Margaret
T1 - Neisseria meningitidis Endotoxin and Capsule Transmission by Transplantation.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2005/08//
VL - 11
IS - 8
M3 - Letter
SP - 1326
EP - 1327
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Presents a letter to the editor about the Neisseria meningitidis endotoxin and capsule transmission by transplantation.
KW - Letters to the editor
KW - Neisseria meningitidis
N1 - Accession Number: 17798437; Roubinian, Nareg 1; Kirkpatrick, Beth D. 1; Lynn, Freyja 2; Zenilman, Jonathan 3; Bash, Margaret 2; Email Address: bash@cber.fda.gov; Affiliations: 1: University of Vermont College of Medicine, Burlington, Vermont, USA; 2: US Food and Drug Administration, Rockville, Maryland, USA; 3: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Issue Info: Aug2005, Vol. 11 Issue 8, p1326; Subject Term: Letters to the editor; Subject Term: Neisseria meningitidis; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xi Huang
AU - Weihong Li
AU - Attfield, Michael D.
AU - Nádas, Arthur
AU - Frenkel, Krystyna
AU - Finkelman, Robert B.
T1 - Mapping and Prediction of Coal Workers' Pneumoconiosis with Bioavailable Iron Content in the Bituminous Coals.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/08//
VL - 113
IS - 8
M3 - Article
SP - 964
EP - 968
PB - Superintendent of Documents
SN - 00916765
AB - Based on the first National Study of Coal Workers' Pneumoconiosis (CWP) and the U.S. Geological Survey database of coal quality, we show that the prevalence of CWP in seven coal mine regions correlates with levels of bioavailable iron (BAI) in the coals from that particular region (correlation coefficient r = 0.94, p < 0.0015). CWP prevalence is also correlated with contents of pyritic sulfur (r = 0.91, p < 0.0048) or total iron (r = 0.85, p < 0.016) but not with coal rank (r = 0.59, p < 0.16) or silica (r = 0.28, p < 0.54). BAI was calculated using our model, taking into account chemical interactions of pyrite, sulfuric acid, calcite, and total iron. That is, iron present in coals can become bioavailable by pyrite oxidation, which produces ferrous sulfate and sulfuric acid. Calcite is the major component in coals that neutralizes the available acid and inhibits iron's bioavailability. Therefore, levels of BAI in the coals are determined by the available amounts of acid after neutralization of calcite and the amount of total iron in the coals. Using the linear fit of CWP prevalence and the calculated BAI in the seven coal mine regions, we have derived and mapped the pneumoconiotic potencies of 7,000 coal samples. Our studies indicate that levels of BAI in the coals may be used to predict coal's toxicity, even before large-scale mining. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational diseases
KW - Bituminous coal
KW - Environmental impact analysis
KW - Environmental risk assessment
KW - Environmental health
KW - Lungs -- Dust diseases
KW - Lung diseases
KW - Coal -- Iron content
KW - United States
KW - bioavailable iron
KW - calcite
KW - chronic obstructive pulmonary disease
KW - coal
KW - COPD
KW - pneumoconiosis
N1 - Accession Number: 17903281; Xi Huang 1; Email Address: xihuang@env.med.nyu.edu; Weihong Li 1; Attfield, Michael D. 2; Nádas, Arthur 1; Frenkel, Krystyna 1; Finkelman, Robert B. 3; Affiliations: 1: Department of Environmental Medicine and NYU Cancer Institute, New York University School of Medicine, New York, New York, USA; 2: Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 3: U.S. Geological Survey, Reston, Virginia, USA; Issue Info: Aug2005, Vol. 113 Issue 8, p964; Thesaurus Term: Occupational diseases; Thesaurus Term: Bituminous coal; Thesaurus Term: Environmental impact analysis; Thesaurus Term: Environmental risk assessment; Thesaurus Term: Environmental health; Subject Term: Lungs -- Dust diseases; Subject Term: Lung diseases; Subject Term: Coal -- Iron content; Subject: United States; Author-Supplied Keyword: bioavailable iron; Author-Supplied Keyword: calcite; Author-Supplied Keyword: chronic obstructive pulmonary disease; Author-Supplied Keyword: coal; Author-Supplied Keyword: COPD; Author-Supplied Keyword: pneumoconiosis; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 212112 Bituminous Coal Underground Mining; NAICS/Industry Codes: 212111 Bituminous Coal and Lignite Surface Mining; Number of Pages: 5p; Document Type: Article
L3 - 10.1289/ehp.7679
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17903281&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Whipkey, Diana L.
AU - Tennant, Lora B.
AU - Weston, Ainsley
T1 - Differential Gene Expression in Normal Human Mammary Epithelial Cells Treated with Malathion Monitored by DNA Microarrays.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/08//
VL - 113
IS - 8
M3 - Article
SP - 1046
EP - 1051
PB - Superintendent of Documents
SN - 00916765
AB - Organophosphate pesticides are a major source of occupational exposure in the United States. Moreover, malathion has been sprayed over major urban populations in an effort to control mosquitoes carrying West Nile virus. Previous research, reviewed by the U.S. Environmental Protection Agency, on the genotoxicity and carcinogenicity of malathion has been inconclusive, although malathion is a known endocrine disruptor. Here, interindividual variations and commonality of gene expression signatures have been studied in normal human mammary epithelial cells from four women undergoing reduction mammoplasty. The cell strains were obtained from the discarded tissues through the Cooperative Human Tissue Network (sponsors: National Cancer Institute and National Disease Research Interchange). Interindividual variation of gene expression patterns in response to malathion was observed in various clustering patterns for the four cell strains. Further clustering identified three genes with increased expression after treatment in all four cell strains. These genes were two aldo-keto reductases (AKR1C1 and AKR1C2) and an estrogen-responsive gene (EBBP). Decreased expression of six RNA species was seen at various time points in all cell strains analyzed: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1), and a gene of unknown function (GenBank accession no. AI859865). Expression changes in all these genes, detected by DNA microarrays, have been verified by real-time polymerase chain reaction. Differential changes in expression of these genes may yield biomarkers that provide insight into interindividual variation in malathion toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cholinesterase-inhibiting insecticides
KW - Occupational hazards
KW - Environmental health
KW - Gene expression
KW - Epithelial cells
KW - Malathion
KW - DNA microarrays
KW - United States
KW - DNA microarray
KW - gene expression
KW - malathion
KW - pesticide
KW - toxicology
N1 - Accession Number: 17903145; Gwinn, Maureen R. 1; Whipkey, Diana L. 2; Tennant, Lora B. 2; Weston, Ainsley 2; Email Address: agw8@cdc.gov; Affiliations: 1: Pathology and Physiology Branch, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 2: Molecular Epidemiology Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: Aug2005, Vol. 113 Issue 8, p1046; Thesaurus Term: Cholinesterase-inhibiting insecticides; Thesaurus Term: Occupational hazards; Thesaurus Term: Environmental health; Subject Term: Gene expression; Subject Term: Epithelial cells; Subject Term: Malathion; Subject Term: DNA microarrays; Subject: United States; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: malathion; Author-Supplied Keyword: pesticide; Author-Supplied Keyword: toxicology; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.7311
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17903145&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106334170
T1 - Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays.
AU - Gwinn MR
AU - Whipkey DL
AU - Tennant LB
AU - Weston A
Y1 - 2005/08//
N1 - Accession Number: 106334170. Language: English. Entry Date: 20060915. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Breast -- Drug Effects
KW - DNA -- Drug Effects
KW - Environmental Exposure -- Adverse Effects
KW - Epithelium -- Drug Effects
KW - Malathion -- Adverse Effects
KW - Breast -- Physiology
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - DNA -- Physiology
KW - In Vitro Studies
KW - West Virginia
KW - Human
SP - 1046
EP - 1051
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 113
IS - 8
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - Organophosphate pesticides are a major source of occupational exposure in the United States. Moreover, malathion has been sprayed over major urban populations in an effort to control mosquitoes carrying West Nile virus. Previous research, reviewed by the U.S. Environmental Protection Agency, on the genotoxicity and carcinogenicity of malathion has been inconclusive, although malathion is a known endocrine disruptor. Here, interindividual variations and commonality of gene expression signatures have been studied in normal human mammary epithelial cells from four women undergoing reduction mammoplasty. The cell strains were obtained from the discarded tissues through the Cooperative Human Tissue Network (sponsors: National Cancer Institute and National Disease Research Interchange). Interindividual variation of gene expression patterns in response to malathion was observed in various clustering patterns for the four cell strains. Further clustering identified three genes with increased expression after treatment in all four cell strains. These genes were two aldo-keto reductases (AKR1C1 and AKR1C2) and an estrogen-responsive gene (EBBP). Decreased expression of six RNA species was seen at various time points in all cell strains analyzed: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1), and a gene of unknown function (GenBank accession no. AI859865). Expression changes in all these genes, detected by DNA microarrays, have been verified by real-time polymerase chain reaction. Differential changes in expression of these genes may yield biomarkers that provide insight into interindividual variation in malathion toxicity.
SN - 0091-6765
AD - Pathology and Physiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
U2 - PMID: 16079077.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mulvey, Kevin P.
AU - Atkinson, Donna Durant
T1 - Evaluation efforts in the era of federal accountability
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2005/08//
VL - 28
IS - 3
M3 - Article
SP - 325
EP - 327
SN - 01497189
AB - Abstract: This special issue of Evaluation and Program Planning presents five articles that discuss the evaluation challenges and issues in implementing the Government Performance and Results Act of 1993 (GPRA) within the Targeted Capacity Expansion (TCE) program sponsored by the Center for Substance Abuse Treatment (CSAT). The goals of these evaluation articles are: (1) to demonstrate how CSAT implemented GPRA within the TCE program; and (2) to demonstrate the effectiveness of TCE grantees in achieving CSAT''s goals. These goals include to: positively influence behaviors related to evaluation activities, reduce the barriers to implementation, and to strengthen the use of research methods that improve the collection of both baseline and follow-up data. In addition to providing an overview of each article, this introduction provides an overview of the Substance Abuse and Mental Health Services Administrations'' (SAMHSA) vision, CSAT''s vision, and a brief context of GPRA. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - ADDICTIONS
KW - ADDICTS
KW - PEOPLE with mental disabilities
KW - Accountability
KW - Capacity building
KW - Evaluation
KW - Government performance & results act
KW - GPRA
KW - Participatory evaluation
KW - Substance abuse
KW - Substance abuse treatment
KW - Substance abuse treatment outcomes
KW - Targeted capacity expansion
KW - TCE
N1 - Accession Number: 18126926; Mulvey, Kevin P. 1; Email Address: kevin.mulvey@samhsa.hhs.gov; Atkinson, Donna Durant 2; Affiliations: 1: Center for Substance Abuse Treatment, SAMHSA, 1 Choke Cherry Road 5-1103, Rockville, MD 20857, USA; 2: ACS/Birch and Davis Associates, Inc., Alexandria, VA, USA; Issue Info: Aug2005, Vol. 28 Issue 3, p325; Subject Term: SUBSTANCE abuse; Subject Term: ADDICTIONS; Subject Term: ADDICTS; Subject Term: PEOPLE with mental disabilities; Author-Supplied Keyword: Accountability; Author-Supplied Keyword: Capacity building; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Government performance & results act; Author-Supplied Keyword: GPRA; Author-Supplied Keyword: Participatory evaluation; Author-Supplied Keyword: Substance abuse; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Substance abuse treatment outcomes; Author-Supplied Keyword: Targeted capacity expansion; Author-Supplied Keyword: TCE; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2005.04.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=18126926&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Atkinson, Donna Durant
AU - Wilson, Maurice
AU - Avula, Deepa
T1 - A participatory approach to building capacity of treatment programs to engage in evaluation
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2005/08//
VL - 28
IS - 3
M3 - Article
SP - 329
EP - 334
SN - 01497189
AB - Abstract: Building the capacity of community-based organizations to engage in evaluation activities has been of primary importance to the Center for Substance Abuse Treatment (CSAT) in its mission to improve treatment services and alleviate substance abuse in communities across the country. One strategy that CSAT uses to encourage this is to engage grantees in evaluation activities so that they are intimately involved in all aspects of the evaluation process. The CSAT Targeted Capacity Expansion (TCE) grantees had an opportunity to participate in the development, design, and execution of an evaluation of their clients'' treatment outcomes. Through this participatory approach, the grantees improved their capacities to conduct evaluation and provided input to the field on treatment outcomes for their specific populations. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRIME
KW - VICTIMLESS crimes
KW - SUBSTANCE abuse
KW - PERSONALITY disorders
KW - Capacity building
KW - Community-based organizations
KW - Empowerment evaluation
KW - Substance abuse treatment
KW - Targeted capacity expansion
KW - TCE
N1 - Accession Number: 18126927; Atkinson, Donna Durant 1; Email Address: donnaatkinson@westat.com; Wilson, Maurice 2; Avula, Deepa 2; Affiliations: 1: ACS/Birch & Davis Associates, Inc. 5270 Shawnee Road, Alexandria, VA 22312, USA; 2: Center for Substance Abuse Treatment, SAMHSA, 1 Choke Cherry Road 5-1103, Rockville, MD 20857, USA; Issue Info: Aug2005, Vol. 28 Issue 3, p329; Thesaurus Term: CRIME; Subject Term: VICTIMLESS crimes; Subject Term: SUBSTANCE abuse; Subject Term: PERSONALITY disorders; Author-Supplied Keyword: Capacity building; Author-Supplied Keyword: Community-based organizations; Author-Supplied Keyword: Empowerment evaluation; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Targeted capacity expansion; Author-Supplied Keyword: TCE; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2005.04.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=18126927&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wilson, Maurice T.
AU - Atanda, Robert
AU - Atkinson, Donna Durant
AU - Mulvey, Kevin
T1 - Outcomes from the targeted capacity expansion (TCE) substance abuse treatment program
JO - Evaluation & Program Planning
JF - Evaluation & Program Planning
Y1 - 2005/08//
VL - 28
IS - 3
M3 - Article
SP - 341
EP - 348
SN - 01497189
AB - Abstract: The Substance Abuse and Mental Health Services Administration (SAMHSA) Center for Substance Abuse Treatment (CSAT), in carrying out its mission to improve access to and the quality of substance abuse treatment services, initiated the Targeted Capacity Expansion (TCE) program—a national initiative, to encourage community-based organizations to expand their existing treatment capacity and implement strategies to evaluate treatment outcomes. Additionally, CSAT sought to provide substance abuse treatment services in communities that had substantial unmet treatment needs. Grantees funded under the TCE program were required to participate in local, regional and national training workshops that covered a variety of topics ranging from program evaluation, interviewing skills, strategies for increasing client follow-up, and data collection. This paper reports the preliminary findings from two components of the TCE program. The results indicate that (1) CSAT was successful in closing gaps in substance abuse treatment services nationally; (2) the TCE initiative provided enhanced treatment substance abuse treatment services to typically underserved populations; (3) substance abuse behaviors and criminal activity resulting from substance abuse were significantly reduced; and (4) critical quality of life factors were improved. [Copyright &y& Elsevier]
AB - Copyright of Evaluation & Program Planning is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG use testing
KW - EMPLOYEES -- Counseling of
KW - SUBSTANCE abuse -- Treatment
KW - Capacity building
KW - Capacity expansion
KW - HIV
KW - Substance abuse treatment
KW - Treatment enhancement
KW - Treatment outcomes
N1 - Accession Number: 18126930; Wilson, Maurice T. 1; Email Address: wilsonmt99@aol.com; Atanda, Robert 1; Atkinson, Donna Durant 1; Mulvey, Kevin 2; Affiliations: 1: ACS/Birch and Davis Associates, Inc. 5270 Shawnee Road, Alexandria, VA 22312, USA; 2: Center for Substance Abuse Treatment, SAMHSA, 1 Choke Cherry Road 5-1103, Rockville, MD 20857, USA; Issue Info: Aug2005, Vol. 28 Issue 3, p341; Thesaurus Term: DRUG use testing; Thesaurus Term: EMPLOYEES -- Counseling of; Subject Term: SUBSTANCE abuse -- Treatment; Author-Supplied Keyword: Capacity building; Author-Supplied Keyword: Capacity expansion; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Substance abuse treatment; Author-Supplied Keyword: Treatment enhancement; Author-Supplied Keyword: Treatment outcomes; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.evalprogplan.2005.04.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=18126930&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - NEWS
AU - Atkins, David
T1 - Hormone therapy increased incidence and severity of urinary incontinence in healthy postmenopausal women: Commentary..
JO - Evidence Based Medicine
JF - Evidence Based Medicine
Y1 - 2005/08//
VL - 10
IS - 4
M3 - Editorial
SP - 121
EP - 121
SN - 13565524
AB - Discusses the role of hormone therapy in treating urinary incontinence (UI) among healthy postmenopausal women. Benefits of oestrogen on genital symptoms; Effects of oestrogen and progestin on UI; Recommendations on drug dosage for the treatment of the disease.
KW - URINARY incontinence
KW - HORMONE therapy
KW - ESTROGEN
KW - MEDICAL research
KW - URINATION disorders
KW - STEROID hormones
N1 - Accession Number: 17937311; Atkins, David 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.; Source Info: Aug2005, Vol. 10 Issue 4, p121; Subject Term: URINARY incontinence; Subject Term: HORMONE therapy; Subject Term: ESTROGEN; Subject Term: MEDICAL research; Subject Term: URINATION disorders; Subject Term: STEROID hormones; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1/4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106297314
T1 - Hormone therapy increased incidence and severity of urinary incontinence in healthy postmenopausal women.
AU - Atkins D
Y1 - 2005/08//
N1 - Accession Number: 106297314. Language: English. Entry Date: 20070608. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary; tables/charts. Original Study: de Vreede PL, Samson MM, van Meeteren NL, Duursma SA, Verhaar HJ. Functional-task exercise versus resistance strength exercise to improve daily function in older women: a randomized, controlled trial. (J AM GERIATR SOC) Jan2005; 53 (1): 2-10. Journal Subset: Biomedical; USA. NLM UID: 9608386.
KW - Hormone Replacement Therapy -- Adverse Effects
KW - Urinary Incontinence -- Epidemiology
KW - Aged
KW - Clinical Trials
KW - Estrogens, Conjugated -- Administration and Dosage
KW - Female
KW - Medroxyprogesterone -- Administration and Dosage
KW - Middle Age
KW - Postmenopause
KW - Treatment Outcomes
KW - United States
KW - Urinary Incontinence -- Physiopathology
SP - 121
EP - 121
JO - Evidence Based Medicine
JF - Evidence Based Medicine
JA - EVID BASED MED
VL - 10
IS - 4
PB - BMJ Publishing Group
SN - 1356-5524
AD - Agency for Healthcare Research and Quality, Rockville, Maryland
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106297314&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Valerio, Jr., Luis G.
T1 - Review: hypericum extracts are safer and lead to fewer adverse effects than older standard antidepressants, but have similar tolerability to SSRIs: Commentary.
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
Y1 - 2005/08//
VL - 8
IS - 3
M3 - Article
SP - 71
EP - 71
SN - 13620347
AB - Comments on a study that showed that hypericum extracts are safer and lead to fewer adverse effects than older standard antidepressants. Mechanism of interaction of hypericum with other therapeutic drugs; Activation of human pregnane X nuclear receptor; Effect of hypericum on efficacy of a combined oral contraceptive.
KW - HYPERICUM
KW - ANTIDEPRESSANTS
KW - CLUSIACEAE
KW - EXTRACTS
KW - DRUG interactions
KW - ORAL contraceptives
N1 - Accession Number: 17937237; Valerio, Jr., Luis G. 1; Affiliation: 1: Toxicologist, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA.; Source Info: Aug2005, Vol. 8 Issue 3, p71; Subject Term: HYPERICUM; Subject Term: ANTIDEPRESSANTS; Subject Term: CLUSIACEAE; Subject Term: EXTRACTS; Subject Term: DRUG interactions; Subject Term: ORAL contraceptives; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - le Fauve, Charlene E.
T1 - Valproate reduces alcohol consumption in people with comorbid alcohol dependency and bipolar disorder: Commentary.
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
Y1 - 2005/08//
VL - 8
IS - 3
M3 - Editorial
SP - 79
EP - 79
SN - 13620347
AB - Comments on the research paper "Efficacy of Valproate Maintenance in Patients With Bipolar Disorder and Alcoholism: A Double-Blind Placebo-Control Led Study," published in the 2005 issue of the journal Archives of General Psychiatry. Focus on providing treatment to alcoholics with co-occurring bipolar I disorder; Challenges associated with clinical medicine for alcohol dependence; Information on the pharmacotherapies and methods of care for patients with mental disorder.
KW - ALCOHOLISM -- Psychological aspects
KW - VALPROIC acid
KW - BIPOLAR disorder
KW - MEDICINE & psychology
KW - PATHOLOGICAL psychology
KW - ARCHIVES of General Psychiatry (Periodical)
N1 - Accession Number: 17937253; le Fauve, Charlene E. 1; Affiliation: 1: Chief, Co-Occurring and Homeless Activities Branch, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Rockville, MD, USA; Source Info: Aug2005, Vol. 8 Issue 3, p79; Subject Term: ALCOHOLISM -- Psychological aspects; Subject Term: VALPROIC acid; Subject Term: BIPOLAR disorder; Subject Term: MEDICINE & psychology; Subject Term: PATHOLOGICAL psychology; Reviews & Products: ARCHIVES of General Psychiatry (Periodical); Number of Pages: 1/4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106524716
T1 - Review: hypericum extracts are safer and lead to fewer adverse effects than older standard antidepressants, but have similar tolerability to SSRIs.
AU - Valerio LG Jr
Y1 - 2005/08//
N1 - Accession Number: 106524716. Language: English. Entry Date: 20051014. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Original Study: Knüppel L, Linde K. Adverse effects of St. John's Wort: a systematic review. J CLIN PSYCHIATRY 2004; 65: 1470-9. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 100883413.
KW - Depression -- Drug Therapy
KW - Drug-Herb Interactions
KW - St. John's Wort -- Therapeutic Use
KW - Meta Analysis
KW - Systematic Review
SP - 71
EP - 71
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
JA - EVID BASED MENT HEALTH
VL - 8
IS - 3
PB - BMJ Publishing Group
AB - Are hypericum extracts safe and tolerable in treating people with depression?METHODSDesign: Systematic review of RCTs with meta-analysis.Data sources: Cochrane Collaborative Review Group for Depression (CCDAN), PubMed, plus hand searches of reference lists; the CCDAN was last searched in July 2003, the PubMed search covered the period 1998 to January 2003.Study selection and analysis: Double blind, randomised, controlled trials comparing hypericum extracts with placebo or standard antidepressant regimens for treatment of depression in adults. Meta-analysis used a fixed effects model as there was no statistical heterogeneity between studies for safety outcomes.Outcomes: Dropouts due to adverse effects, numbers reporting adverse effects.MAIN RESULTSThirty five published RCTs met criteria for inclusion in the review (24 trials comparing hypericum extracts with placebo, seven comparing hypericum extracts with older antidepressants, and six comparing hypericum with selective serotonin reuptake inhibitors (SSRIs)). Compared with placebo, hypericum resulted in similar numbers of dropouts due to adverse effects (24 RCTs, 8/1334 (0.6%) with hypericum v 15 (1.2%) with placebo, OR 0.61, 95% CI 0.28 to 1.31). There was no significant difference between hypericum and placebo in the number of people reporting adverse effects (236/1123 (21%) with hypericum v 254/1077 (23.6%) with placebo, OR 0.79, 95% CI 0.61 to 1.03). Compared with older antidepressants, treatment with hypericum led to fewer dropouts for adverse effects and fewer reports of adverse effects (seven RCTs, dropouts for adverse effects: 14/615 (2.3%) with hypericum v 52/616 (8.4%) with amitriptyline, imipramine, or maprotiline, OR 0.25, 95% CI 0.14 to 0.45; reports of adverse effects: 174/615 (11.1%) with hypericum v 301/616 (15.6%) with amitriptyline, imipramine, or maprotiline, OR 0.39, 95% CI 0.31 to 0.50). There were no significant differences between hypericum and SSRIs in numbers dropping out for adverse effects or total adverse effects reported, though the trend was for fewer adverse effects with hypericum (dropouts due to adverse effects: OR 0.60, 95% CI 0.31 to 1.15, total numbers reporting adverse effects: OR 0.75, 95% CI 0.52 to 1.08).CONCLUSIONSWith respect to adverse effects, hypericum extracts are better tolerated than older standard antidepressants (amitriptyline, imipramine, or maprotiline), though dropout rates and adverse effects are similar with hypericum, SSRIs, and no treatment.NOTESShort follow up periods and small sample sizes may increase the chance that potential adverse effects were overlooked in RCTs. The review also included a review of large observational studies and of case series and individual case reports from drug surveillance agencies. Large observational studies in primary care settings found that rates of treatment discontinuation were low and adverse effects were rare. Individual case reports provide evidence that interactions do occur between hypericum and other drugs, but these are rare.
SN - 1362-0347
AD - Toxicologist, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD
U2 - PMID: 16043613.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106524733
T1 - Valproate reduces alcohol consumption in people with comorbid alcohol dependency and bipolar disorder.
AU - Le Fauve CE
Y1 - 2005/08//
N1 - Accession Number: 106524733. Language: English. Entry Date: 20051014. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Original Study: Salloum IM, Cornelius JR, Daley DC et al. Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism -- a double-blind placebo-controlled study. ARCH GEN PSYCHIATRY 2005; 62: 37-45. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 100883413.
KW - Alcoholism -- Drug Therapy
KW - Bipolar Disorder -- Drug Therapy
KW - Valproic Acid -- Therapeutic Use
KW - Double-Blind Studies
SP - 79
EP - 79
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
JA - EVID BASED MENT HEALTH
VL - 8
IS - 3
PB - BMJ Publishing Group
AB - Is valproate an effective adjuvant treatment for bipolar disorder with co-occurring alcohol dependence?METHODS:Design: Randomised controlled trial. Allocation: Not reported. Blinding: Double blind (assessors and participants blinded to treatment group). Follow up period: Twenty four weeks.Setting: University of Pittsburgh Medical Center, USA. Patients: Fifty nine men and women aged 18-65 years with both an alcohol use disorder (meeting four of seven DSM-IV criteria for alcohol dependence) and an acute episode of bipolar 1 disorder. Exclusion criteria included: schizophrenia or schizoaffective disorder, non-bipolar psychotic disorder, opioid or cocaine dependence or current use of intravenous drugs, epilepsy or history of organic brain syndrome or brain injury, unstable medical conditions, and elevated liver enzymes. Women were excluded if they were pregnant or breast feeding.Intervention: The intervention consisted of valproate (divalproex sodium) at a starting dose of 750 mg/day, increased until serum concentration reached 50 to 100 microg/ml. The placebo group received identical capsules twice daily. All participants continued to receive usual care, consisting of lithium treatment and weekly individual psychosocial counselling, throughout the study.Outcomes: Proportion of heavy drinking (>/=4 drinks/day for women or >/=5 drinks/day for men) days and number of drinks per heavy drinking day (measured using Timeline Follow-Back for Recent Drinking), remission of mania (measured using the Bech-Rafaelsen Mania Scale (BRMS)), and remission of depression (measured using the Hamilton Rating Scale for Depression (HRSD-25)), assessed every four weeks. Patient follow up: 20/59 (38%) completed the study at 24 weeks.MAIN RESULTSFollowing treatment with valproate, there was a significant decrease in number of heavy drinking days and a non-significant reduction in drinks per heavy drinking day (people reporting heavy drinking days: 12/27 (44%) with valproate v 17/25 (68%) with placebo; p = 0.02, number of drinks per heavy drinking days: 5.6 with valproate v 10.2 with placebo; p = 0.055), which became significant when adherence to treatment was controlled for in analysis (p = 0.02). Valproate also increased time to relapse of heavy drinking (days to relapse: 93 with valproate v 62 with placebo; p = 0.048). Valproate had no effect on overall symptoms of mania or depression (BRMS score after treatment: 5.6 with valproate v 6.1 with placebo; p = 0.87, HRSD-25 score after treatment: 16.3 with valproate v 14.4 with placebo; p = 0.36), although there was a trend towards a reduction in time to remission of mania with valproate (p = 0.07). Mania and depression were strongly associated with alcohol consumption (p = 0.006).CONCLUSIONSIn people with comorbid bipolar and alcohol abuse disorder, treatment with valproate is an effective adjunct to lithium and psychosocial counseling and reduces alcohol consumption. Valproate has little effect on mania and depressive symptoms.NOTESThere was a very high dropout of participants in this study, so clinical significance of these results remain unclear. Participants were taking lithium and were having weekly psychosocial counselling throughout the study period.
SN - 1362-0347
AD - Chief, Co-Occuring and Homeless Activities Branch, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Rockville, MD
U2 - PMID: 16043621.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106524733&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kraman, Matthew
AU - McCright, Brent
T1 - Functional conservation of Notch1 and Notch2 intracellular domains.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2005/08//
VL - 19
IS - 10
M3 - Article
SP - 1311
EP - 1313
AB - Presents a study on the differences in the signaling capabilities of the Notch1 and Notch2 intracellular domains. Function of Notch genes; Creation of mice expressing a Notch2-Notch1 fusion protein; Analysis of blood samples from Notch2N1in homozygotes.
KW - NOTCH genes
KW - DROSOPHILA -- Genetics
KW - GENE expression
KW - PROTEINS
KW - BLOOD analysis
N1 - Accession Number: 17959061; Kraman, Matthew 1 McCright, Brent 1; Email Address: mccright@cber.fda.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration Bethesda, Maryland, USA; Source Info: Aug2005, Vol. 19 Issue 10, p1311; Subject Term: NOTCH genes; Subject Term: DROSOPHILA -- Genetics; Subject Term: GENE expression; Subject Term: PROTEINS; Subject Term: BLOOD analysis; Number of Pages: 3p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1096/fj.04-3407fje
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ferguson, Sherry A.
AU - Cisneros, F. Javier
AU - Gough, Bobby J.
AU - Ali, Syed F.
T1 - Four weeks of oral isotretinoin treatment causes few signs of general toxicity in male and female Sprague–Dawley rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/08//
VL - 43
IS - 8
M3 - Article
SP - 1289
EP - 1296
SN - 02786915
AB - Abstract: Despite widespread use of isotretinoin for its anti-acne effects and its current evaluation in clinical trials as a cancer treatment, little is known about its general toxicity in adult nonpregnant animals, particularly after oral administration which mimics the human route. Here, adult male and female Sprague-Dawley rats were gavaged daily with 0 (soy oil), 7.5, or 15mg/kg isotretinoin for 28 days during which time body weight, food/water intake, and estrous phase were measured. At sacrifice, organ weights were collected and concentrations of dopamine (DA), serotonin and metabolites were measured in frontal cortex, striatum, hippocampus, and diencephalon. Food intake was mildly decreased in both treated groups (≈15% in males and 7% in females); however, body weight and water consumption were unaffected. The estrous cycle appeared slightly affected (i.e., lengthened by 15mg/kg, and both treated groups appeared to have less time in diestrus and more time in estrus). Kidney/body weight ratio was decreased by 7.5 and 15mg/kg isotretinoin and spleen/body weight ratio was increased in the 7.5mg/kg group. Males of the 7.5mg/kg group exhibited significantly higher gonad/body weight ratios than did same-sex controls. Concentrations of monoamine and metabolites in the frontal cortex and diencephalon were unaffected. Nor were striatal DA and DOPAC concentrations affected; however, there were isolated effects on striatal HVA and 5-HIAA. Hippocampal DA concentrations were marginally increased. These data indicate mild effects resulting from oral isotretinoin treatment at doses which likely produce serum levels within the range of humans. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOTRETINOIN
KW - ACNE -- Treatment
KW - CANCER treatment
KW - RATS as laboratory animals
KW - CLINICAL trials
KW - Adult
KW - Dopamine
KW - Isotretinoin
KW - Retinoic acid
KW - Toxicity
N1 - Accession Number: 17919421; Ferguson, Sherry A.; Email Address: sferguson@nctr.fda.gov Cisneros, F. Javier 1 Gough, Bobby J. 1 Ali, Syed F. 1; Affiliation: 1: Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900, NCTR Road, Jefferson, AR 72079, USA; Source Info: Aug2005, Vol. 43 Issue 8, p1289; Subject Term: ISOTRETINOIN; Subject Term: ACNE -- Treatment; Subject Term: CANCER treatment; Subject Term: RATS as laboratory animals; Subject Term: CLINICAL trials; Author-Supplied Keyword: Adult; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Isotretinoin; Author-Supplied Keyword: Retinoic acid; Author-Supplied Keyword: Toxicity; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2005.02.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoke, Eileen M.
AU - Maylock, Caroline A.
AU - Shacter, Emily
T1 - Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2005/08//
VL - 39
IS - 3
M3 - Article
SP - 403
EP - 411
SN - 08915849
AB - Abstract: Desferal is a clinically approved iron chelator used to treat iron overload. Doxorubicin is an anthracycline cancer chemotherapy drug used in the treatment of breast cancer. It can undergo redox cycling in the presence of iron to produce reactive oxygen species. The oxidant-generating activity of doxorubicin is thought to be responsible for the cardiotoxic side effects of the drug, but it is unclear whether it is also required for its anti-tumor activity. To test whether an iron-chelating antioxidant would interfere with the tumor-killing activity of doxorubicin, nude mice were transplanted with xenografts of human breast cancer MDA-MB 231 cells and then treated with doxorubicin and/or desferal. Not only did desferal not interfere with the anti-tumor activity of doxorubicin, it inhibited tumor growth on its own. In vitro studies confirmed that desferal inhibits breast tumor growth. However, it did not induce apoptosis, nor did it induce cell cycle arrest. Instead, desferal caused cytostasis, apparently through iron depletion. The cytostatic activity of desferal was partially ameliorated by pretreatment with iron-saturated transferrin, and transferrin receptor expression on breast cancer cells nearly doubled after exposure to desferal. In contrast to its effect on tumor cells, desferal did not inhibit growth of normal breast epithelial cells. The data indicate that the anti-tumor activity of doxorubicin is not dependent on iron-mediated ROS production. Furthermore, desferal may have utility as an adjunctive chemotherapy due to its ability to inhibit breast tumor growth and cardiotoxic side effects without compromising the tumor-killing activity of an anthracycline chemotherapy drug. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - ANTINEOPLASTIC agents
KW - CHEMOTHERAPY (Cancer)
KW - FREE radicals (Chemistry)
KW - DRUGS -- Physiological effect
KW - Antioxidants
KW - Breast cancer
KW - Chemotherapy
KW - Desferal
KW - Doxorubicin
KW - Free radicals
KW - Iron
KW - Oxidants
N1 - Accession Number: 18092937; Hoke, Eileen M. 1 Maylock, Caroline A. 1 Shacter, Emily 2; Email Address: emily.shacter@fda.gov; Affiliation: 1: Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA 2: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892–4555, USA; Source Info: Aug2005, Vol. 39 Issue 3, p403; Subject Term: BREAST cancer; Subject Term: ANTINEOPLASTIC agents; Subject Term: CHEMOTHERAPY (Cancer); Subject Term: FREE radicals (Chemistry); Subject Term: DRUGS -- Physiological effect; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: Chemotherapy; Author-Supplied Keyword: Desferal; Author-Supplied Keyword: Doxorubicin; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Iron; Author-Supplied Keyword: Oxidants; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2005.03.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Han, Jing
AU - Lee, Hin
AU - Nguyen, Nga Yen
AU - Beaucage, Serge L.
AU - Puri, Raj K.
T1 - Novel multiple 5′-amino-modified primer for DNA microarrays
JO - Genomics
JF - Genomics
Y1 - 2005/08//
VL - 86
IS - 2
M3 - Article
SP - 252
EP - 258
SN - 08887543
AB - Abstract: For DNA microarray analysis, total RNA is reverse-transcribed, labeled by incorporating fluorescent dye into the cDNA, and used to hybridize microarray. This protocol requires a minimum of 20 μg of total RNA. To overcome the sample limitation, an RNA amplification technique has been developed. Although it needs less RNA, this amplification technique is relatively expensive, time consuming, and, unfortunately, has been found to introduce bias. In this study, we designed a novel 5′-amino-modified primer and used it for priming cDNA synthesis. The novel primer has a special structure that contains four Uni-Link molecules with two nucleotide (thymine) residues inserted between them as spacers. This novel primer is used in the reverse-transcription reaction for cDNA synthesis. Using the novel 5′-modified primer combined with indirect labeling method, cDNA probes can be prepared with much less total RNA (5 μg or less) without amplification producing optimal results after hybridization of arrays. This primer can also be used to label nucleotides for other purposes. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - HYBRIDIZATION
KW - NUCLEOTIDES
KW - GENETIC transcription
KW - Microarray
KW - Novel multiple 5′-amino-modified primer
KW - Signal intensity
KW - Uni-Link molecules
N1 - Accession Number: 18090998; Han, Jing 1 Lee, Hin 1 Nguyen, Nga Yen 2 Beaucage, Serge L. 3 Puri, Raj K. 1; Email Address: puri@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Bethesda, MD 20892, USA 2: Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA 3: Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Aug2005, Vol. 86 Issue 2, p252; Subject Term: NUCLEIC acids; Subject Term: HYBRIDIZATION; Subject Term: NUCLEOTIDES; Subject Term: GENETIC transcription; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Novel multiple 5′-amino-modified primer; Author-Supplied Keyword: Signal intensity; Author-Supplied Keyword: Uni-Link molecules; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ygeno.2005.04.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mukamel, Dana B.
AU - Spector, William D.
AU - Bajorska, Alina
T1 - Nursing Home Spending Patterns in the 1990s: The Role of Nursing Home Competition and Excess Demand.
JO - Health Services Research
JF - Health Services Research
Y1 - 2005/08//
VL - 40
IS - 4
M3 - Article
SP - 1040
EP - 1055
PB - Wiley-Blackwell
SN - 00179124
AB - To examine nursing home expenditures on clinical, hotel, and administrative activities during the 1990s and to determine the association between nursing home competition and excess demand on expenditures. Secondary data sources for 1991, 1996, and 1999 for 500 free-standing nursing homes in New York State. A retrospective statistical analysis of nursing homes' expenditures. The dependent variables were clinical, hotel, and administrative costs in each year. Independent variables included outputs (inpatient and outpatient), wages, ownership, New York City location, and measures of competition and excess demand. Variables were constructed from annual financial reports submitted by the nursing homes, the Patient Review Instrument and Medicare enrollment data. Clinical and administrative costs have increased over the decade, while hotel expenditures have declined. Increased competition was associated with higher clinical and administrative costs while excess demand was associated with lower clinical and hotel expenditures. Nursing home expenditures are sensitive to competition and excess demand conditions. Policies that influence competition in nursing home markets are therefore likely to have an impact on expenditures as well. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities
KW - NURSING care facilities -- Rates
KW - HEALTH facilities
KW - MEDICARE
KW - STATISTICS
KW - MEDICAL care
KW - competition
KW - costs
KW - excess demand
KW - Nursing homes
N1 - Accession Number: 17519441; Mukamel, Dana B. 1 Spector, William D. 2 Bajorska, Alina 3; Affiliation: 1: Associate Professor, Department of Medicine, Division of General Internal Medicine and Primary Care and Senior Fellow, Center for Health Policy Research, University of California, Irvine, 111 Academy Way, Suite 220, Irvine, CA. 2: Agency for Healthcare Research and Quality, Washington, DC. 3: Community and Preventive Medicine, University of Rochester, Rochester, NY.; Source Info: Aug2005, Vol. 40 Issue 4, p1040; Subject Term: NURSING care facilities; Subject Term: NURSING care facilities -- Rates; Subject Term: HEALTH facilities; Subject Term: MEDICARE; Subject Term: STATISTICS; Subject Term: MEDICAL care; Author-Supplied Keyword: competition; Author-Supplied Keyword: costs; Author-Supplied Keyword: excess demand; Author-Supplied Keyword: Nursing homes; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 16p; Document Type: Article
L3 - 10.1111/j.1475-6773.2005.00394.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104741700
T1 - Quality-based payment: six case examples.
AU - McNamara, Peggy
Y1 - 2005/08//
N1 - Accession Number: 104741700. Language: English. Entry Date: 20110610. Revision Date: 20161117. Publication Type: journal article; review. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9434628.
KW - Quality of Health Care -- Economics
KW - Reimbursement Mechanisms -- Economics
KW - Benchmarking
KW - Developed Countries
KW - Developing Countries
KW - Private Sector -- Economics
KW - Private Sector -- Standards
KW - Public Sector -- Economics
KW - Public Sector -- Standards
KW - Quality of Health Care -- Standards
KW - Reimbursement Mechanisms -- Standards
SP - 357
EP - 362
JO - International Journal for Quality in Health Care
JF - International Journal for Quality in Health Care
JA - INT J QUAL HEALTH CARE
VL - 17
IS - 4
PB - Oxford University Press / USA
AB - Introduction: The logic of paying more for high-quality care and less for low-quality resonates. Increasingly health system leaders worldwide acknowledge that payment reforms are needed to do just that, prompted no doubt by the growing body of evidence indicating that quality is not what it should be.Purpose: This review was undertaken to explore contexts in which quality-based payment appears feasible. The ultimate intent is to provoke thoughtful debate about whether and how quality-based payment might fit within a particular developing country's framework of policies to ensure and promote quality of care.Methods: With guidance from key informants with first-hand knowledge of international quality-based payment schemes, a purposive sample of six quality-based payment schemes was assembled. Schemes were examined to identify environmental contexts and design features.Results: Examples illustrate a variety of approaches and a breadth of contexts in which quality-based payment has been implemented. Contrary to what might be expected, implementation does not appear to be constrained to private-sector purchasers, private-sector providers, hospital settings, nor to any particular type of underlying payment system. Further, quality-based payment pioneers are using a variety of incentive structures, and are tapping a rich mix of structural, process, and outcome standards to benchmark quality.Conclusion: Despite significant operational challenges, quality-based payment has been implemented in developing as well as developed countries, albeit not frequently in either instance. What we do not know--what the literature is nearly silent on--relates to the sustainability and ultimate impact of alternative incentive schemes.
SN - 1353-4505
AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD 20850, USA. pmcnamar@ahrq.gov
U2 - PMID: 15879011.
DO - intqhc/mzi033
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - J. T. Magee
T1 - The resistance ratchet: theoretical implications of cyclic selection pressure.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2005/08//
VL - 56
IS - 2
M3 - Article
SP - 427
EP - 430
SN - 03057453
N1 - Accession Number: 18250109; J. T. Magee 1; Affiliations: 1: al Public Health Service for Wales, Abton House, Wedal Road, Cardiff CF14 3QX, Wales, UK, 1 , Tel: +44-29-2052-1997; Fax: +44-29-2052-1987; E-mail: john.magee@nphs.wales.nhs.uk; Issue Info: Aug2005, Vol. 56 Issue 2, p427; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106541250
T1 - Relationship of distress and perceived control to coping with perceived racial discrimination among black youth.
AU - Scott LD Jr.
AU - House LE
Y1 - 2005/08//
N1 - Accession Number: 106541250. Language: English. Entry Date: 20051118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Self-Report Coping Scale (SRCS) (Causey and Dubow); Daily Life Experiences Scale (DLE-F); Racism Experiences Stress Scale (EXP-STR). NLM UID: 7904302.
KW - Attitude -- Ethnology -- In Adolescence
KW - Blacks -- Psychosocial Factors -- In Adolescence
KW - Control (Psychology) -- In Adolescence
KW - Coping -- In Adolescence
KW - Racism -- In Adolescence
KW - Stress, Psychological -- In Adolescence
KW - Adolescence
KW - Construct Validity
KW - Correlation Coefficient
KW - Correlational Studies
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Middle Age
KW - One-Way Analysis of Variance
KW - Problem Solving
KW - Questionnaires
KW - Regression
KW - Reliability
KW - Scales
KW - Self Report
KW - Sex Factors
KW - Socioeconomic Factors
KW - Summated Rating Scaling
KW - Support, Psychosocial
KW - Human
SP - 254
EP - 272
JO - Journal of Black Psychology
JF - Journal of Black Psychology
JA - J BLACK PSYCHOL
VL - 31
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - This study examines the use of approach (e.g., seeking social support, problem solving) and avoidance (e.g., distancing, internalizing, externalizing) strategies for coping with perceived racial discrimination and their relationship to the subjective feelings of distress evoked by perceived experiences of discrimination and perceived control over discriminatory experiences among a small, relatively homogeneous sample of Black youth (N = 71). Results of hierarchical regression analyses support evidence from the general adolescent stress and coping literature that links avoidance coping to greater feelings of distress and approach coping to a greater sense of personal control. Greater self-reports of distress are related to greater use of internalizing and externalizing coping strategies. Greater self-reports of perceived control over discriminatory experiences are related to greater use of seeking social support and problem-solving coping strategies. Implications for promoting the successful coping of Black youth with perceived racial discrimination are discussed.
SN - 0095-7984
AD - Research Associate, Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, Campus Box 1093, One Brookings Dr, St Louis, MO 63130; lscott@gwbmail.wustl.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Renter, David G.
AU - Morris Jr., J. Glenn
AU - Sargeant, Jan M.
AU - Hungerford, Laura L.
AU - Berezowski, John
AU - Thao Ngo
AU - Williams, Karen
AU - Acheson, David W. K.
T1 - Prevalence, Risk Factors, O Serogroups, and Virulence Profiles of Shiga Toxin—Producing Bacteria from Cattle Production Environments.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/08//
VL - 68
IS - 8
M3 - Article
SP - 1556
EP - 1565
SN - 0362028X
AB - Shiga toxin (Stx)-producing bacteria are important human pathogens that have been linked with cattle and associated food products. We recovered Stx-producing bacteria from 27.5% of cattle, 6.8% of water, and 2.3% of wildlife samples from a cattle production area during an 11-month period. Positive samples were found during every month and on 98% of sampling days. We recovered isolates from all cattle operations sampled, and prevalence within operations ranged from approximately 5 to 33%. Cattle prevalence was associated with the presence of Stx-producing bacteria in water and the production group and environment of cattle, with an interaction between production group and environment. Odds of recovering isolates from cattle were highest for groups of adult cows and their unweaned calves in pasture environments. Overall, 49 O serogroups were identified from 527 isolates. Seventy of the isolates contained virulence genes that encoded intimin and enterohemorrhagic Escherichia coli hemolysin. These were serogroups O111, O157, O109, O103, O145, O172, 084, 026, O108, O117, O126, O159, O5, O69, O74, O98, and O-rough. Our results suggest that the prevalence of Stx-producing bacteria can be relatively high in cattle, and associated factors may not be entirely similar to those reported for serotype O157:H7. Although Stx-producing bacteria were frequently detected, the strains may not be equally pathogenic for humans given the wide variety of serogroups and virulence genes. However, focusing on O157:H7 in food safety and surveillance programs may allow other Stx-producing bacteria, which appear to be widespread in cattle, to go undetected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - Escherichia coli
KW - Pathogenic microorganisms
KW - Bacteria
KW - Cattle -- Pathogens
N1 - Accession Number: 17932775; Renter, David G. 1,2; Email Address: drenter@vet.ksu.edu; Morris Jr., J. Glenn 3; Sargeant, Jan M. 4; Hungerford, Laura L. 3; Berezowski, John 2; Thao Ngo 5; Williams, Karen 3; Acheson, David W. K. 6; Affiliations: 1: Department ot Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA; 2: Agri-Food Systems Branch, Food Safety Division, Alberta Agriculture, Food and Rural Development, Edmonton, Alberta, Canada T6H 4P2; 3: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA; 4: Department of Clinical Epidemiology and Biostatistics, Health Sciences Centre, McMaster University, Hamilton, Ontario, Canada L8N 3Z5; 5: Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111, USA; 6: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; Issue Info: Aug2005, Vol. 68 Issue 8, p1556; Thesaurus Term: Food pathogens; Thesaurus Term: Escherichia coli; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Bacteria; Subject Term: Cattle -- Pathogens; Number of Pages: 10p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Michael A. Grant
T1 - Comparison of a New Enrichment Procedure for Shiga Toxin—Producing Escherichia coil with Five Standard Methods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/08//
VL - 68
IS - 8
M3 - Article
SP - 1593
EP - 1599
SN - 0362028X
AB - A new procedure for enrichment of Escherichia coli O157:H7 and other Shiga toxin-producing E. coli was compared to five standard methods: the British Public Health Laboratory Service, International Standard Method, U.S. Department of Agriculture, Canadian Health Products and Food Branch, and U.S. Food and Drag Administration. The new procedure was comparable to the standard methods in its ability to detect target cells inoculated into foods at approximately 1 CFU g-1. Comparisons were also made of the ability of the six enrichment procedures to detect E. coli O157:H7 against a large background of competitor microorganisms. In these experiments the new procedure yielded more target cells than the other five enrichments by two to three orders of magnitude as determined by enumeration on sorbitol MacConkey agar with tellurite and cefixime and Rainbow agar with tellurite and novobiocin and by verification of presumptive colonies by real-time PCR. For example, the population of enterohemorrhagic E. coli strain 6341 recovered on sorbitol MacConkey agar with tellurite and cefixime after enrichment with the experimental method was 2.42 × 108 CFU ml-1 and 1.80 × 106 CFU ml-1 after enrichment with the Canadian Health Products and Food Branch method, the second most effective in this experiment. In addition, broth cultures resulting from each of the six enrichment procedures were used to prepare templates for real-time PCR detection of stx1/stx2. Resulting threshold cycle (Ct) values after the experimental enrichment were similar to positive control values, whereas the five standard methods produced delayed Ct values or were not detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Escherichia
KW - Microorganisms
KW - Food -- Quality
KW - Tellurites
N1 - Accession Number: 17932780; Michael A. Grant 1; Email Address: mike.grant@fda.gov; Affiliations: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 23rd Drive S.E., Bothell, Washington 98021, USA; Issue Info: Aug2005, Vol. 68 Issue 8, p1593; Thesaurus Term: Escherichia coli; Thesaurus Term: Escherichia; Thesaurus Term: Microorganisms; Subject Term: Food -- Quality; Subject Term: Tellurites; Number of Pages: 7p; Illustrations: 4 Charts, 16 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Meldrum, R. J.
AU - Ribeiro, C. D.
AU - Smith, R. M. M.
AU - Walker, A. M.
AU - Simmons, M.
AU - Worthington, D.
AU - Edwards, C.
T1 - Microbiological Quality of Ready-to-Eat Foods: Results from a Long-Term Surveillance Program (1995 through 2003).
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/08//
VL - 68
IS - 8
M3 - Article
SP - 1654
EP - 1658
SN - 0362028X
AB - The coordination of food sampling activities across Wales, a part of the United Kingdom with a population of approximately 3 million, led to the establishment in 1995 of a coordinated food-sampling program designed to monitor on a long-term basis the microbiological quality and safety of specific ready-to-eat products. This surveillance system has been ongoing for 9 years and has generated a database of microbiological and associated demographic results for 15,228 ready-to-eat food samples. The food types that had the poorest overall results were sliced meats, unsliced poultry, sandwiches made without salad, and cakes made without dairy cream. For all food types, the overall unsatisfactory rate was 17% for aerobic colony counts, 1.6% for Escherichia coli, and 0.5% for Listeria spp. Overall unsatisfactory or unacceptable rates for pathogens such as Clostridium perfringens, Listeria monocytogenes, Bacillus cereus, and Staphylococcus aureus were all below 0.5%. No Campylobacter-positive samples and only one Salmonella-positive sample were found. The analysis of the results show that the ready-to-eat food types sampled over the 9 years of the program were generally of good microbiological quality when compared with current United Kingdom guidelines. The information contained in the database provides a baseline measurement of the microbial quality of a variety of ready-to-eat foods and allows environmental health officers and food microbiologists to generate hypotheses for targeted surveys or research work. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Microbiology
KW - Sanitary microbiology
KW - Food pathogens
KW - Clostridium perfringens
KW - Listeria monocytogenes
KW - Wales
N1 - Accession Number: 17932789; Meldrum, R. J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Ribeiro, C. D. 1; Smith, R. M. M. 2; Walker, A. M. 3; Simmons, M. 4; Worthington, D. 4; Edwards, C. 5; Affiliations: 1: Public Health Laboratory, National Public Health Service (NPHS) for Wales, Llandough Hospital, PenIan Road, Penarth CF64 2XX, UK; 2: CDSC Wa/ac, Abton House, Wedal Road, Cardiff CR4 3QX, UK; 3: Public Health Laboratory, NPHS for Wales, Ysbyzy Gwynedd, Bangor LL57 2PW, UK; 4: Office of the Chief Medical Officer, Welsh Assembly Government, Crown Buildings, Cathays Park, Cardiff UK; 5: Caerphilly County Borough Council, Council Offices, Pontllanfraidd, Blackwood MP12 2YW, UK; Issue Info: Aug2005, Vol. 68 Issue 8, p1654; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Sanitary microbiology; Thesaurus Term: Food pathogens; Subject Term: Clostridium perfringens; Subject Term: Listeria monocytogenes; Subject: Wales; Number of Pages: 5p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trumbo, Paula R.
T1 - Are there Adverse Effects of Lycopene Exposure?
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2005/08//
VL - 135
IS - 8
M3 - Article
SP - 2060S
EP - 2061S
SN - 00223166
AB - The article examines the adverse effects of lycopene exposure. Formulated lycopene is synthetic, includes antioxidants to prevent lycopene oxidation, and is a common form in which lycopene supplements are marketed. Mice were given a single dose of 3 g/kg crystalline lycopene by various routes of administration. There were no adverse effects when mice were given lycopene orally or intraperitoneally. There was, however, a transient decrease in body tone when lycopene was given by subcutaneous injection. There is a dearth of information on the adverse effects of lycopene in humans. Lycopenemia, characterized by an orange discoloration of the skin, has been observed with high intakes of lycopene-containing foods. One case study reported the incidence of lycopenemia in a 6- year-old woman who had consumed approximately 2 litre of tomato juice daily for several years. Although there was evidence of lycopene and fatty deposits in the liver, there was in absence of measurable hepatic dysfunction. After 3 wk of consuming a diet free of tomato juice, the orange discoloration faded.
KW - LYCOPENE
KW - CAROTENES
KW - BILIARY tract
KW - MICE as laboratory animals
KW - TOMATO juice
KW - TOMATO products
KW - lycopene
KW - safety
KW - tomatoes
KW - toxicity
N1 - Accession Number: 17989215; Trumbo, Paula R. 1; Email Address: paula.trumbo@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740.; Source Info: Aug2005, Vol. 135 Issue 8, p2060S; Subject Term: LYCOPENE; Subject Term: CAROTENES; Subject Term: BILIARY tract; Subject Term: MICE as laboratory animals; Subject Term: TOMATO juice; Subject Term: TOMATO products; Author-Supplied Keyword: lycopene; Author-Supplied Keyword: safety; Author-Supplied Keyword: tomatoes; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106512199
T1 - Ototoxic occupational exposures for a stock car racing team: I. Noise surveys.
AU - Van Campen LE
AU - Morata T
AU - Kardous CA
AU - Gwin K
AU - Wallingford KM
AU - Dallaire J
AU - Alvarez FJ
Y1 - 2005/08//
N1 - Accession Number: 106512199. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D65-6. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Motor Sports
KW - Noise
KW - Occupational Exposure
KW - Education, Continuing (Credit)
KW - National Institute for Occupational Safety and Health
KW - Human
SP - 383
EP - 390
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety and Health (NIOSH) surveyed noise exposure for a professional stock car team at their race shop and during two races at one racetrack. At the team's shop, area sound pressure levels (SPLs) were measured for various work tasks. Equivalent levels (Leqs) ranged from 58 to 104 decibels, A-weighted (dBA). Personal noise dosimetry was conducted for at least one employee for each job description in race car assembly (n = 9). The Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) of 90 dBA for an 8-hour, 5-dB exchange rate time-weighted average (TWA) was never exceeded, but in two instances values exceeded OSHA's action level of 85 dBA for hearing conservation implementation. The NIOSH recommended exposure limit (REL) of 85 dBA for a 3-dB exchange rate Leq was exceeded for five of the measured jobs. During the races, SPLs averaged above 100 dBA in the pit area where cars undergo adjustments/refueling, both before and during the race. Peak levels reached 140 dB SPL. NIOSH REL was exceeded for every personal noise dosimetry measurement. Recommendations for hearing protection and communication are presented.
SN - 1545-9624
AD - Hearing Loss Prevention Team, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16080260.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106512200
T1 - Reducing respirator fit test errors: a multi-donning approach.
AU - Campbell DL
AU - Coffey CC
AU - Jensen PA
AU - Zhuang Z
Y1 - 2005/08//
N1 - Accession Number: 106512200. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; tables/charts. Note: For CE see Suppl pages D65-6. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Evaluation
KW - Education, Continuing (Credit)
KW - Statistics
SP - 391
EP - 399
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - As a continuation of recent studies to assess the accuracy of existing fit test methods, a multi-donning approach to fit testing is presented. As an example of that approach, a multi-donning quantitative fit test for filtering-facepiece respirators is presented and analyzed by comparing its error rates with those of the single-donning approach of current fit test methods. That analysis indicates the multi-donning fit test has the potential to reduce both the alpha error and the beta error to half that of single-donning fit tests. The alpha error is the error of failing a respirator that should pass; the beta error is the error of passing a respirator that should fail. Lowering fit test error rates for filtering-facepiece respirators is important because fit testing is an essential means of helping assure that an individual has selected an adequately fitting respirator. To reduce the alpha and beta error inherent in current fit test methods, the proposed fit test for filtering-facepiece respirators incorporates five donnings of the facepiece, unlike the single donning of existing fit test methods. The analysis presented here indicates that the multiple-donning approach reduces the element of chance in the fit test result and thereby increases the consistency and accuracy of the fit tests. The time to conduct the multi-donning test can approximate the time for current, single-donning tests by shortening the time the respirator is worn after each donning to about 10 sec. And, unlike current fit tests for filtering-facepieces that measure only faceseal leakage, the example multiple-donning fit test considered here is based on a measurement of total leakage (faceseal plus filter). Utilizing total respirator leakage can result in simpler quantitative fit test instrumentation and a fit test that is more relevant to the workplace. Further trials with human subjects are recommended in order to validate the proposed multi-donning approach.
SN - 1545-9624
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 16080261.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106512204
T1 - Ototoxic occupational exposures for a stock car racing team: II. Chemical surveys.
AU - Gwin KK
AU - Wallingford KM
AU - Morata TC
AU - Van Campen LE
AU - Dallaire J
AU - Alvarez FJ
Y1 - 2005/08//
N1 - Accession Number: 106512204. Language: English. Entry Date: 20050909. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D65-6. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Carbon Monoxide
KW - Lead
KW - Motor Sports
KW - Occupational Exposure
KW - Solvents
KW - Education, Continuing (Credit)
KW - National Institute for Occupational Safety and Health
KW - Human
SP - 406
EP - 413
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety and Health (NIOSH) conducted a series of surveys to evaluate occupational exposure to noise and potentially ototoxic chemical agents among members of a professional stock car racing team. Exposure assessments included site visits to the team's race shop and a worst-case scenario racetrack. During site visits to the race team's shop, area samples were collected to measure exposures to potentially ototoxic chemicals, including, organic compounds (typical of solvents), metals, and carbon monoxide (CO). Exposures to these chemicals were all below their corresponding Occupational Safety and Health Administration (OSHA) permissible exposure limits (PELs), NIOSH recommended exposure limits (RELs), and American Conference of Governmental Industrial Hygienists (ACGIH[R]) threshold limit values (TLVs[R]). During site visits to the racetrack, area and personal samples were collected for organic compounds, lead, and CO in and around the 'pit' area where the cars undergo race preparation and service during the race. Exposures to organic compounds and lead were either nondetectable or too low to quantify. Twenty-five percent of the CO time-weighted average concentrations exceeded the OSHA PEL, NIOSH REL, and ACGIH TLV after being adjusted for a 10-hour workday. Peak CO measurements exceeded the NIOSH recommended ceiling limit of 200 ppm. Based on these data, exposures to potentially ototoxic chemicals are probably not high enough to produce an adverse effect greater than that produced by the high sound pressure levels alone. However, carbon monoxide levels occasionally exceeded all evaluation criteria at the racetrack.
SN - 1545-9624
AD - Hazard Evaluations and Technical Assistance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16009649.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kortejärvi, H.
AU - Yliperttula, M.
AU - Dressman, J.B.
AU - Junginger, H.E.
AU - Midha, K.K.
AU - Shah, V.P.
AU - Barends, D.M.
T1 - Biowaiver monographs for immediate release solid oral dosage forms: Ranitidine hydrochloride.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2005/08//
VL - 94
IS - 8
M3 - Article
SP - 1617
EP - 1625
SN - 00223549
AB - Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence testing for the approval of immediate release (IR) solid oral dosage forms containing ranitidine hydrochloride are reviewed. According to the current Biopharmaceutics Classification System (BCS), ranitidine hydrochloride should be assigned to Class III. However, based on its therapeutic and therapeutic index, pharmacokinetic properties and data related to the possibility of excipient interactions, a biowaiver can be recommended for IR solid oral dosage forms that are rapidly dissolving and contain only those excipients as reported in this study. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:1617–1625, 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANITIDINE
KW - BIOPHARMACEUTICS
KW - DOSAGE of drugs
KW - DRUGS -- Therapeutic equivalency
KW - PHARMACOKINETICS
KW - THERAPEUTICS
KW - absorption
KW - Biopharmaceutics Classification System (BCS)
KW - permeability
KW - ranitidine
KW - solubility
N1 - Accession Number: 22171128; Kortejärvi, H. 1 Yliperttula, M. 1 Dressman, J.B. 2 Junginger, H.E. 3 Midha, K.K. 4 Shah, V.P. 5 Barends, D.M. 6; Affiliation: 1: Orion Pharma, Research and Development, Espoo, Finland 2: Institut für Pharmazeutische Technologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany 3: Leiden/Amsterdam Center for Drug Research, Leiden University, Division of Pharmaceutical Technology, Leiden, The Netherlands 4: University of Saskatchewan, Saskatoon, Canada 5: U.S. Food and Drug Administration, Center of Drug Evaluation and Research, Rockville, Maryland 6: RIVM, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Source Info: Aug2005, Vol. 94 Issue 8, p1617; Subject Term: RANITIDINE; Subject Term: BIOPHARMACEUTICS; Subject Term: DOSAGE of drugs; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: PHARMACOKINETICS; Subject Term: THERAPEUTICS; Author-Supplied Keyword: absorption; Author-Supplied Keyword: Biopharmaceutics Classification System (BCS); Author-Supplied Keyword: permeability; Author-Supplied Keyword: ranitidine; Author-Supplied Keyword: solubility; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Minton, Allen P.
T1 - Influence of macromolecular crowding upon the stability and state of association of proteins: Predictions and observations.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2005/08//
VL - 94
IS - 8
M3 - Article
SP - 1668
EP - 1675
SN - 00223549
AB - The concept of excluded volume and possible effects of excluded volume on the reactivity of macromolecules in highly volume-occupied or ‘crowded’ media are introduced and briefly summarized. Theoretical and experimental studies of the effect of crowding on protein folding and unfolding, and on the effect of crowding on protein association and aggregation, are reviewed. Possible effects of the effect of crowding on an initially native protein that can undergo unfolding, self-association of native protein, and/or aggregation of non-native protein are considered. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:1668–1675, 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROMOLECULES
KW - PROTEIN folding
KW - DENATURATION of proteins
KW - MOLECULES
KW - SUPRAMOLECULAR chemistry
KW - macromolecular excipients
KW - protein aggregation
KW - protein denaturation
N1 - Accession Number: 22171122; Minton, Allen P. 1; Affiliation: 1: Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Public Health Service, Bethesda, Maryland; Source Info: Aug2005, Vol. 94 Issue 8, p1668; Subject Term: MACROMOLECULES; Subject Term: PROTEIN folding; Subject Term: DENATURATION of proteins; Subject Term: MOLECULES; Subject Term: SUPRAMOLECULAR chemistry; Author-Supplied Keyword: macromolecular excipients; Author-Supplied Keyword: protein aggregation; Author-Supplied Keyword: protein denaturation; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mackey, E. A.
AU - Paul, R. L.
AU - Lindstrom, R. M.
AU - Anderson, D. L.
AU - Greenberg, R. R.
T1 - Sources of uncertainties in prompt gamma activation analysis.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2005/08//
VL - 265
IS - 2
M3 - Article
SP - 273
EP - 281
SN - 02365731
AB - Two prompt gamma-ray activation analysis (PGAA) facilities at the NIST Center for Neutron Research have been used routinely to perform elemental analyses of a variety of materials. Results from these analyses are usually expressed as mass fraction values with expanded uncertainties. The expanded uncertainty consists of the combined uncertainty multiplied by the appropriate coverage factor (k) required to achieve a 95% confidence interval. The combined uncertainty includes the uncertainties associated with preparation, irradiation, and γ-ray spectrometry of samples and standards, and corrections for γ-rays from the background or blanks where necessary. To determine the combined uncertainty, each component of uncertainty associated with each variable and constant in the basic measurement equation is evaluated. In this paper we present the PGAA measurement equation, a description of the potential sources of uncertainty for each component of the equation, and three examples of uncertainty evaluation. The examples are for determination of H in standard reference material (SRM) 2454, hydrogen in titanium alloy using the cold neutron PGAA facility, Cd in SRM 2702 Inorganics in Marine Sediment using the original thermal neutron PGAA facility, and N in SRM 3244 Ephedra-Containing Protein Powder using the recently designed thermal neutron PGAA facility. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATTER -- Constitution
KW - TITANIUM -- Hydrogen content
KW - THERMAL neutrons
KW - COLD neutrons
KW - SEDIMENTATION & deposition
KW - IRRADIATION
N1 - Accession Number: 17671947; Mackey, E. A. 1 Paul, R. L. 1 Lindstrom, R. M. 1 Anderson, D. L. 2 Greenberg, R. R.; Affiliation: 1: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8395, USA. 2: Elemental Research Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park MD 20740-3835, USA.; Source Info: Aug2005, Vol. 265 Issue 2, p273; Subject Term: MATTER -- Constitution; Subject Term: TITANIUM -- Hydrogen content; Subject Term: THERMAL neutrons; Subject Term: COLD neutrons; Subject Term: SEDIMENTATION & deposition; Subject Term: IRRADIATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s10967-005-0820-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The dependencies of phase velocity and dispersion on trabecular thickness and spacing in trabecular bone-mimicking phantoms.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2005/08//
VL - 118
IS - 2
M3 - Article
SP - 1186
EP - 1192
SN - 00014966
AB - Frequency-dependent phase velocity was measured in trabecular-bone-mimicking phantoms consisting of two-dimensional arrays of parallel nylon wires (simulating trabeculae) with thicknesses ranging from 152 to 305 μm and spacings ranging from 700 to 1000 μm. Phase velocity varied approximately linearly with frequency over the range from 400 to 750 kHz. Dispersion was characterized by the slope of a linear least-squares regression fit to phase velocity versus frequency data. The increase in phase velocity (compared with that in water) at 500 kHz was approximately proportional to the (1) square of trabecular thickness, (2) inverse square of trabecular spacing, and (3) volume fraction occupied by nylon wires. The first derivative of phase velocity with respect to frequency was negative and exhibited nonlinear, monotonically decreasing dependencies on trabecular thickness and volume fraction. The dependencies of phase velocity and its first derivative on volume fraction in the phantoms were consistent with those reported in trabecular bone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSIS
KW - SPEED of sound
KW - LEAST squares
KW - FREQUENCY (Linguistics)
KW - ULTRASONIC waves -- Speed
KW - ULTRASONICS in medicine
N1 - Accession Number: 20263382; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142, 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Aug2005, Vol. 118 Issue 2, p1186; Subject Term: DIAGNOSIS; Subject Term: SPEED of sound; Subject Term: LEAST squares; Subject Term: FREQUENCY (Linguistics); Subject Term: ULTRASONIC waves -- Speed; Subject Term: ULTRASONICS in medicine; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1121/1.1940448
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20263382&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barletta, Janet M.
AU - Edelman, Daniel C.
AU - Highsmith, W.E.
AU - Constantine, Niel T.
T1 - Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2005/08//
VL - 127
IS - 2
M3 - Article
SP - 154
EP - 164
SN - 01660934
AB - Abstract: Pathologic prion protein (PrPSc), implicated in transmissible spongiform encephalopathies, is detected by antibody-based tests or bioassays to confirm the diagnosis of prion diseases. Presently, the Western blot or an ELISA is officially used to screen the brain stem in cattle for the presence of PrPSc. The immuno-polymerase chain reaction (IPCR), a technique whereby the exponential amplification ability of PCR is coupled to the detection of proteins by antibodies in an ELISA format, was applied in a modified real-time IPCR method to detect ultra-low levels of prion protein. Using IPCR, recombinant hamster PrPC was consistently detected at 1fg/mL and proteinase K (PK)-digested scrapie infected hamster brain homogenates diluted to 10−8 (approximately 10–100 infectious units) was detected with a semi-quantitative dose response. This level of detection is 1million-fold more sensitive than the levels detected by Western blot or ELISA and poises IPCR as a method capable of detecting PrPSc in the pre-clinical phase of infection. Further, the data indicate that unless complete PK digestion of PrPC in biological materials is verified, ultrasensitive assays such as IPCR may inaccurately classify a sample as positive. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRION diseases
KW - POLYMERASE chain reaction
KW - ENZYME-linked immunosorbent assay
KW - BIOLOGICAL assay
KW - BSE
KW - Immuno-PCR
KW - IPCR
KW - Prion
KW - PrPC
KW - PrPSc
KW - Real-time IPCR
KW - Scrapie
KW - TSE
N1 - Accession Number: 18027154; Barletta, Janet M. 1; Email Address: barlettaj@cder.fda.gov Edelman, Daniel C. 2 Highsmith, W.E. 3 Constantine, Niel T. 2; Affiliation: 1: Food and Drug Administration CDER/OPS/Microbiology, Rockville, MD, USA 2: Department of Pathology, University of Maryland Baltimore, 725 W. Lombard St., Baltimore, MD 21201, USA 3: Department of Laboratory Medicine and Pathology, Division of Laboratory Genetics, Mayo Clinic, Rochester, MD, USA; Source Info: Aug2005, Vol. 127 Issue 2, p154; Subject Term: PRION diseases; Subject Term: POLYMERASE chain reaction; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: BIOLOGICAL assay; Author-Supplied Keyword: BSE; Author-Supplied Keyword: Immuno-PCR; Author-Supplied Keyword: IPCR; Author-Supplied Keyword: Prion; Author-Supplied Keyword: PrPC; Author-Supplied Keyword: PrPSc; Author-Supplied Keyword: Real-time IPCR; Author-Supplied Keyword: Scrapie; Author-Supplied Keyword: TSE; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jviromet.2005.04.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18027154&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106523001
T1 - Racial and ethnic differences in the mental health problems and use of mental health care.
AU - Harris KM
AU - Edlund MJ
AU - Larson S
Y1 - 2005/08//
N1 - Accession Number: 106523001. Language: English. Entry Date: 20051007. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: SAMHSA's Office of Applied Studies, a Research Career Development Award (RCD-03-036) from the VA Health Services Research and Development Services, and the Agency for Healthcare Research and Quality. NLM UID: 0230027.
KW - Health Resource Utilization -- Trends
KW - Mental Health Services -- Utilization
KW - Psychiatric Care -- Trends
KW - Race Factors
KW - Adult
KW - Asians
KW - Blacks
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Hispanics
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Native Americans
KW - Odds Ratio
KW - P-Value
KW - T-Tests
KW - Whites
KW - Human
SP - 775
EP - 784
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 43
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: We compared rates of mental health problems and use of mental health care across multiple racial and ethnic groups using secondary data from a large, nationally representative survey. METHODS: We pooled cross-sectional data from the 2001-2003 National Surveys on Drug Use and Health. Our sample included 134,875 adults classified as white, African American, American Indian/Alaskan Native, Asian, Mexican, Central and South American, Puerto Rican, other Hispanic-Latino, or those with multiple race and ethnicities. For each group, we estimate the past year probability of: (1) having 1 or more mental health symptoms in the past year, (2) having serious mental illness in the past year, (3) using mental health care, (4) using mental health care conditional on having mental health problems, (5) reporting unmet need for mental health care, and (6) reporting unmet need for mental health care conditional on having mental health problems. RESULTS: We found significantly higher rates of mental health problems and higher self-reported unmet need relative to whites among American Indian/Alaskan Natives and lower rates of mental health problems and use of mental health care among African American, Asian, Mexican, Central and South American, and other Hispanic-Latino groups. These differences generally were robust to the inclusion of clinical and socio demographic covariates. CONCLUSIONS: Overall, our study shows wide variation in mental health morbidity and use of mental health care across racial and ethnic groups in the United States. These results can help to focus efforts aimed at understanding the underlying causes of the differences we observe.
SN - 0025-7079
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16-105, Rockville, MD 20856; kharris@samhsa.gov
U2 - PMID: 16034291.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106523001&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Impact of Stretch-Shortening Cycle Rest Interval on in Vivo Muscle Performance.
AU - Cutlip, Robert G.
AU - Geronilla, Ken B.
AU - Baker, Brent A.
AU - Chetlin, Robert D.
AU - Hover, Ian
AU - Kashon, Mike L.
AU - Wu, John Z.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2005/08//
VL - 37
IS - 8
SP - 1345
EP - 1355
CY - ;
SN - 01959131
N1 - Accession Number: SPHS-1014624; Author: Cutlip, Robert G.: 1 email: rgc8@cdc.gov. Author: Geronilla, Ken B.: 2 Author: Baker, Brent A.: 3 Author: Chetlin, Robert D.: 4 Author: Hover, Ian: 5 Author: Kashon, Mike L.: 6 Author: Wu, John Z.: 7 ; Author Affiliation: 1 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 2 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 3 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 4 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 5 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 6 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA: 7 National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, USA; No. of Pages: 11; Language: English; Parent Item: SPHP1978; References: 30; General Notes: Applied sciences: biodynamics.; Publication Type: Article; Material Type: PRINT; Update Code: 20070901; SIRC Article No.: S-1014624
N2 - Introduction: Overuse and overtraining models have implicated both metabolic and mechanical disturbances as contributors to muscle damage and performance decrement but have produced equivocal results. The purpose of the present study was to investigate the impact of rest interval between sets of stretch-shortening cycles (SSC) on static and dynamic muscle performance Methods: Animals were randomly assigned to groups (N = 8 per group) of 10-s, 1-min, or 5-min rest between sets of isometric contractions (10-s, 1-min, or 5-min CON), or SSC (10-s, 1-min, or 5-min INJ). The dorsiflexor muscles were exposed in vivo to either seven sets of 10 SSC (500 degrees.s-1) or seven sets of isometric contractions. Performance was characterized by isometric exertions and positive, negative, and net work, at pretest, during the sets of SSC, and 48 h postexposure Results: The isometric force at 48 h after the 10-s and 5-min INJ groups were statistically different from the 1-min group (P < 0.05), whereas there was no difference in the CON groups. Negative work of the INJ groups were statistically lower at 48 h than pretest values (P < 0.05), whereas there was no change in positive work. Of the real-time parameters, there was a difference in minimum force and positive work (P < 0.05) with treatment with the 10-s INJ group being most affected Conclusion: SSC conducted at shorter work-rest cycles resulted in a more profound isometric force decrement 48 h postexposure, and in real-time changes in isometric prestretch force and positive work. These results indicate that short rest intervals between athletic or vocational tasks of heightened physical exertion (i.e., high intensity) may adversely affect performance and increase injury susceptibility. [ABSTRACT FROM AUTHOR]
KW - *MUSCLE contraction
KW - *PHYSIOLOGY
KW - *BIOMECHANICS
KW - *MUSCLES
KW - *STRETCHING exercises
KW - *ISOMETRIC exercise
KW - *WOUNDS & injuries
KW - MUSCULOSKELETAL system -- Wounds & injuries
KW - RATS
KW - FORCE & energy
KW - TESTING
KW - ANGLES (Geometry)
L2 - http://articles.sirc.ca/search.cfm?id=S-1014624
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=SPHS-1014624&site=ehost-live&scope=site
UR - http://articles.sirc.ca/search.cfm?id=S-1014624
UR - http://www.wwilkins.com
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106431508
T1 - Impact of stretch-shortening cycle rest interval on in vivo muscle performance.
AU - Cutlip RG
AU - Geronilla KB
AU - Baker BA
AU - Chetlin RD
AU - Hover I
AU - Kashon ML
AU - Wu JZ
Y1 - 2005/08//2005 Aug
N1 - Accession Number: 106431508. Language: English. Entry Date: 20060428. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8005433.
KW - Recovery, Exercise
KW - Time Factors
KW - Muscle Contraction
KW - Isometric Exercises
KW - Muscle, Skeletal -- Pathology
KW - Muscle Strength
KW - Exercise Physiology
KW - Animal Studies
KW - In Vivo Studies
KW - Random Assignment
KW - Rats
KW - Descriptive Statistics
KW - Data Analysis Software
KW - Analysis of Variance
KW - Repeated Measures
KW - Post Hoc Analysis
KW - Pearson's Correlation Coefficient
SP - 1345
EP - 1355
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
JA - MED SCI SPORTS EXERC
VL - 37
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - INTRODUCTION: Overuse and overtraining models have implicated both metabolic and mechanical disturbances as contributors to muscle damage and performance decrement but have produced equivocal results. The purpose of the present study was to investigate the impact of rest interval between sets of stretch-shortening cycles (SSC) on static and dynamic muscle performance METHODS: Animals were randomly assigned to groups (N = 8 per group) of 10-s, 1-min, or 5-min rest between sets of isometric contractions (10-s, 1-min, or 5-min CON), or SSC (10-s, 1-min, or 5-min INJ). The dorsiflexor muscles were exposed in vivo to either seven sets of 10 SSC (500 degrees . s) or seven sets of isometric contractions. Performance was characterized by isometric exertions and positive, negative, and net work, at pretest, during the sets of SSC, and 48 h postexposure RESULTS: The isometric force at 48 h after the 10-s and 5-min INJ groups were statistically different from the 1-min group (P < 0.05), whereas there was no difference in the CON groups. Negative work of the INJ groups were statistically lower at 48 h than pretest values (P < 0.05), whereas there was no change in positive work. Of the real-time parameters, there was a difference in minimum force and positive work (P < 0.05) with treatment with the 10-s INJ group being most affected. CONCLUSION: SSC conducted at shorter work-rest cycles resulted in a more profound isometric force decrement 48 h postexposure, and in real-time changes in isometric prestretch force and positive work. These results indicate that short rest intervals between athletic or vocational tasks of heightened physical exertion (i.e., high intensity) may adversely affect performance and increase injury susceptibility.
SN - 0195-9131
AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Don Nehlen Drive, M/S 2027, Morgantown, WV 26505; rgc8@cdc.gov
U2 - PMID: 16118582.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106431508&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baoguang Li
AU - Brown, Eric W.
AU - D'Agostino, Christine
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Structure and distribution of the phosphoprotein phosphatase genes, prpA and prpB, among Shigella subgroups.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2005/08//
VL - 151
IS - 8
M3 - Article
SP - 2671
EP - 2683
SN - 13500872
AB - Phosphoprotein phosphatases encoded by the prpA and prpB genes function in signal transduction pathways for degradation of misfolded proteins in the extracytoplasmic compartments of Escherichia coli. In order to trace the evolution of pip genes and assess their roles in other enteric pathogens, the structure and distribution of these genes among closely related Shigella subgroups were studied. PCR amplification, probe hybridization studies and DNA sequencing were used to determine the prp genotypes of 58 strains from the four Shigella subgroups, Dysenteriae. Boydii, Sonnei and Flexneri. It was found that the prp alleles among Shigella subgroups were extremely susceptible to gene inactivation and that the mutations involved in pip allele inactivation were varied. They included IS insertions, gene replacement by an PS element, a small deletion within the gene or large deletion engulfing the entire gene region. and base substitutions that generated premature termination codons. As a result, of 58 strains studied, only eight (14 %) possessed intact prpA and prpB genes. Of the Shigella strains examined, 760/c (44/58) showed at least one of the pip alleles inactivated by one or more IS elements. including IS1, 1S4, 15600 and 1S629. Phylogenetic analysis revealed that PS elements have been independently acquired in multiple lineages of Shigella, suggesting that loss of functional alleles has been advantageous during Shigella strain evolution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbiology (13500872) is the property of Society for General Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Shigella
KW - Enterobacteriaceae
KW - Pathogenic microorganisms
KW - Phosphoprotein phosphatases
KW - Genes
KW - Microbial genetics
KW - Genetic polymorphisms
N1 - Accession Number: 18002818; Baoguang Li 1; Brown, Eric W. 1; D'Agostino, Christine 1; LeClerc, J. Eugene 1; Cebula, Thomas A. 1; Email Address: tcebula@cfsan.fda.gov; Affiliations: 1: Division of Molecular Biology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA.; Issue Info: Aug2005, Vol. 151 Issue 8, p2671; Thesaurus Term: Shigella; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Pathogenic microorganisms; Subject Term: Phosphoprotein phosphatases; Subject Term: Genes; Subject Term: Microbial genetics; Subject Term: Genetic polymorphisms; Number of Pages: 13p; Document Type: Article
L3 - 10.1099/mic.0.27990-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xu, Z.
AU - Cawthon, D.
AU - McCastlain, K.A.
AU - Duhart, H.M.
AU - Newport, G.D.
AU - Fang, H.
AU - Patterson, T.A.
AU - Slikker, W.
AU - Ali, S.F.
T1 - Selective Alterations of Transcription Factors in MPP+-Induced Neurotoxicity in PC12 Cells
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2005/08//
VL - 26
IS - 4
M3 - Article
SP - 729
EP - 737
SN - 0161813X
AB - Abstract: MPP+ (1-methyl-4-phenylpyridinium; the active metabolite of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine)) depletes dopamine (DA) content and elicits cell death in PC12 cells. However, the mechanism of MPP+-induced neurotoxicity is still unclear. In this study, the dose response and time-course of MPP+-induced DA depletion and decreased cell viability were determined in nerve growth factor (NGF)-differentiated PC12 cells. The alteration of transcription factors (TFs) induced by MPP+ from a selected dose level and time point was then evaluated using protein/DNA-binding arrays. K-means clustering analysis identified four patterns of protein/DNA-binding changes. Three of the 28 TFs identified in PC12 cells increased by 100% (p53, PRE, Smad SBE) and 2 decreased by 50% (HSE, RXR(DR1)) of control with MPP+ treatment. In addition, three TFs decreased within the range of 33–50% (TFIID, E2F1, CREB) and two TFs increased within the range of 50–100% (PAX-5, Stat4). An electrophoretic mobility shift assay (EMSA) was used to confirm the changes of p53 and HSE. The observed changes in TFs correlated with the alterations of DA and cell viability. The data indicates that selective transcription factors are involved in MPP+-induced neurotoxicity and it provides mechanistic information that may be applicable to animal studies with MPTP and clinical studies of Parkinson''s disease. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOPAMINE
KW - NEUROTOXICOLOGY
KW - NERVE Growth Factor
KW - CELL death
KW - TRANSCRIPTION factors
KW - PARKINSON'S disease
KW - NERVOUS system -- Diseases
KW - 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine ( MPTP )
KW - 1-methyl-4-phenylpyridinium ( MPP+ )
KW - Cell viability
KW - Differentiated PC12 cells
KW - dihydroxylbenzylamine ( DHBA )
KW - Dopamine
KW - dopamine ( DA )
KW - MPP+
KW - Neurotoxicity
KW - Protein/DNA array
KW - reactive oxygen species ( ROS )
KW - Transcription factor
KW - transcription factor ( TF )
N1 - Accession Number: 18233132; Xu, Z. 1 Cawthon, D. 1 McCastlain, K.A. 1 Duhart, H.M. 1 Newport, G.D. 1 Fang, H. 2 Patterson, T.A. 1 Slikker, W. 1 Ali, S.F. 1; Email Address: sali@nctr.fda.gov; Affiliation: 1: Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Bioinformatics Division, Z-Tech Corporation, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Aug2005, Vol. 26 Issue 4, p729; Subject Term: DOPAMINE; Subject Term: NEUROTOXICOLOGY; Subject Term: NERVE Growth Factor; Subject Term: CELL death; Subject Term: TRANSCRIPTION factors; Subject Term: PARKINSON'S disease; Subject Term: NERVOUS system -- Diseases; Author-Supplied Keyword: 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine ( MPTP ); Author-Supplied Keyword: 1-methyl-4-phenylpyridinium ( MPP+ ); Author-Supplied Keyword: Cell viability; Author-Supplied Keyword: Differentiated PC12 cells; Author-Supplied Keyword: dihydroxylbenzylamine ( DHBA ); Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: dopamine ( DA ); Author-Supplied Keyword: MPP+; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Protein/DNA array; Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: Transcription factor; Author-Supplied Keyword: transcription factor ( TF ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.neuro.2004.12.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18233132&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bobak, M.
AU - Pikhart, H.
AU - Kubinova, R.
AU - Malyutina, S.
AU - Pajak, A.
AU - Sebakova, H.
AU - Topor-Madry, R.
AU - Nikitin, Y.
AU - Caan, W.
AU - Marmot, M.
T1 - The association between psychosocial characteristics at work and problem drinking: a cross-sectional study of men in three Eastern European urban populations.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2005/08//
VL - 62
IS - 8
M3 - Article
SP - 546
EP - 550
SN - 13510711
AB - Background: Psychosocial factors at work are thought to influence health partly through health behaviours. Aims: To examine the association between effort-reward imbalance and job control and several alcohol related measures in three eastern European populations. Methods: A cross-sectional study was conducted in Novosibirsk (Russia), Krakow (Poland), and Karvina (Czech Republic). The participants completed a questionnaire that included effort-reward at work, job control, and a number of sociodemographic variables. Annual alcohol intake, annual number of drinking sessions, the mean dose of alcohol per drinking session, and binge drinking (≥80 g of ethanol in one session at least once a week) were based on graduated frequencies in the questionnaire. Data were also available on problem drinking (≥2 positive answers on CAGE questionnaire) and negative social consequences of drinking. All male participants in full employment (n = 694) were included in the present analyses. Results: After controlling for age and centre, all indices of alcohol consumption and problem drinking were associated with the effort-reward ratio. Adjustment for material deprivation did not change the results but adjustment for depressive symptoms reduced the estimated effects. Job control was not associated with any of the alcohol related outcomes. Conclusions: The imbalance of effort-reward at work is associated with increased alcohol intake and problem drinking. The association appears to be partly mediated by depressive symptoms, which might be either an antecedent or a consequence of men's drinking behaviour. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drinking of alcoholic beverages
KW - Psychosocial factors
KW - Work environment
KW - Depressed persons
KW - Mental depression
KW - Health behavior
KW - Medicine & psychology
N1 - Accession Number: 17928542; Bobak, M. 1; Email Address: m.bobak@ucl.ac.uk; Pikhart, H. 1; Kubinova, R. 2; Malyutina, S. 3; Pajak, A. 4; Sebakova, H. 5; Topor-Madry, R. 4; Nikitin, Y. 3; Caan, W. 6; Marmot, M. 1; Affiliations: 1: International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, UK.; 2: Centre for Environmental health, Notional Institute of Public Health, Prague, Czech Republic.; 3: Institute of Internal Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.; 4: Deportment of Epidemiology and Population Sciences, Jagiellonian University, Krakow, Poland.; 5: Regional Public Health Service, Ostrava, Czech Republic.; 6: Department of Public and Family Health, Anglia Polytechnic University, Chelmsford, UK.; Issue Info: Aug2005, Vol. 62 Issue 8, p546; Subject Term: Drinking of alcoholic beverages; Subject Term: Psychosocial factors; Subject Term: Work environment; Subject Term: Depressed persons; Subject Term: Mental depression; Subject Term: Health behavior; Subject Term: Medicine & psychology; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1136/oem.2004.017202
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=17928542&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106344018
T1 - FDA drug approval summary: erlotinib (TARCEVA) tablets.
AU - Cohen MH
AU - Johnson JR
AU - Chen Y
AU - Sridhara R
AU - Pazdur R
Y1 - 2005/08//
N1 - Accession Number: 106344018. Language: English. Entry Date: 20061006. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Drug Approval
KW - Lung Neoplasms -- Drug Therapy
KW - Enzyme Inhibitors -- Therapeutic Use
KW - Antineoplastic Agents -- Therapeutic Use
KW - Treatment Outcomes
KW - Clinical Trials
KW - Double-Blind Studies
KW - Placebos
KW - Univariate Statistics
KW - Confidence Intervals
KW - Adult
KW - Middle Age
KW - Female
KW - Male
KW - Human
SP - 461
EP - 466
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 10
IS - 7
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On November 18, 2004, erlotinib (Tarceva); OSI Pharmaceuticals, Inc., Melville, NY, http://www.osip.com, and Genentech, Inc., South San Francisco, CA, http://www.gene.com) received regular approval as monotherapy for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen. Survival of erlotinib-treated patients was superior to that of placebo-treated patients. The median survival duration of erlotinib-treated patients was 6.67 months, compared with 4.70 months for placebo-treated patients. Exploratory univariate analyses showed a larger survival prolongation in two subsets of patients: those who never smoked and those with epidermal growth factor receptor (EGFR)-positive tumors. Patients who never smoked and were EGFR-positive had a large erlotinib survival benefit. Erlotinib was also superior to placebo for progression-free survival and a response rate of 8.9% versus 0.9%. Skin rash and diarrhea were the most common erlotinib adverse events. Severe rash occurred in 8%, and severe diarrhea occurred in 6% of erlotinib-treated patients. In the first-line treatment of NSCLC, two large, controlled, randomized trials showed no benefit from adding erlotinib to doublet, platinum-based chemotherapy. Therefore, erlotinib is not indicated for use in this setting.
SN - 1083-7159
AD - U.S. Food and Drug Administration, HFD-150, 5600 Fishers Lane, Rockville, Maryland 20857; cohenma@cder.fda.gov
U2 - PMID: 16079312.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106344018&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ho-Jong Ju
AU - Samuels, Timmy D.
AU - Yuh-Shuh Wang
AU - Blancaflor, Elison
AU - Payton, Mark
AU - Mitra, Ruchira
AU - Krishnamurthy, Konduru
AU - Nelson, Richard S.
AU - Verchot-Lubicz, Jeanmarie
T1 - The Potato Virus X TGBp2 Movement Protein Associates with Endoplasmic Reticulum-Derived Vesicles during Virus Infection.
JO - Plant Physiology
JF - Plant Physiology
Y1 - 2005/08//
VL - 138
IS - 4
M3 - Article
SP - 1877
EP - 1895
SN - 00320889
AB - The green fluorescent protein (GFP) gene was fused to the potato virus X (PVX) TGBp2 gene, inserted into either the PVX infectious clone or pRTL2 plasmids, and used to study protein subcellular targeting. In protoplasts and plants inoculated with PVX-GFP:TGBp2 or transfected with pRTL2-GFP:TGBp2, fluorescence was mainly in vesicles and the endoplasmic reticulum (ER). During late stages of virus infection, fluorescence became increasingly cytosolic and nuclear. Protoplasts transfected with PVX-GFP:TGBp2 or pRTL2-GFP:TGBp2 were treated with cycloheximide and the decline of GFP fluorescence was greater in virus-infected protoplasts than in pRTL2-GFP:TGBp2-transfected protoplasts. Thus, protein instability is enhanced in virus-infected protoplasts, which may account for the cytosolic and nuclear fluorescence during late stages of infection. Immunogold labeling and electron microscopy were used to further characterize the GFP:TGBp2-induced vesicles. Label was associated with the ER and vesicles, but not the Golgi apparatus. The TGBp2-induced vesicles appeared to be ER derived. For comparison, plasmids expressing GFP fused to TGBp3 were transfected to protoplasts, bombarded to tobacco leaves, and studied in transgenic leaves. The GFP:TGBp3 proteins were associated mainly with the ER and did not cause obvious changes in the endomembrane architecture, suggesting that the vesicles reported in GFP:TGBp2 studies were induced by the PVX TGBp2 protein. In double-labeling studies using confocal microscopy, fluorescence was associated with actin filaments, but not with Golgi vesicles. We propose a model in which reorganization of the ER and increased protein degradation is linked to plasmodesmata gating. [ABSTRACT FROM AUTHOR]
AB - Copyright of Plant Physiology is the property of American Society of Plant Physiologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GREEN fluorescent protein
KW - FLUORESCENT polymers
KW - PLANT proteins
KW - PLANT polymers
KW - PLANT genetics
KW - PLANT genetic engineering
KW - ENDOPLASMIC reticulum
KW - CELL organelles
KW - PLANT physiology
N1 - Accession Number: 18184810; Ho-Jong Ju 1 Samuels, Timmy D. 1 Yuh-Shuh Wang 2 Blancaflor, Elison 2 Payton, Mark 3 Mitra, Ruchira 1,4 Krishnamurthy, Konduru 1,5 Nelson, Richard S. 2 Verchot-Lubicz, Jeanmarie 1; Email Address: verchot@okstate.edu; Affiliation: 1: Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, Oklahoma 74078 2: Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401 3: Department of Statistics, Oklahoma State University, Stillwater, Oklahoma 74078 4: Department of Plant and Soil Science, Delaware Biotechnology Institute, Newark, DE 19711 5: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; Source Info: Aug2005, Vol. 138 Issue 4, p1877; Subject Term: GREEN fluorescent protein; Subject Term: FLUORESCENT polymers; Subject Term: PLANT proteins; Subject Term: PLANT polymers; Subject Term: PLANT genetics; Subject Term: PLANT genetic engineering; Subject Term: ENDOPLASMIC reticulum; Subject Term: CELL organelles; Subject Term: PLANT physiology; Number of Pages: 19p; Document Type: Article
L3 - 10.1104/pp.105.066019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106373830
T1 - Use of mental health care and substance abuse treatment among adults with co-occurring disorders.
AU - Harris KM
AU - Edlund MJ
Y1 - 2005/08//
N1 - Accession Number: 106373830. Language: English. Entry Date: 20060106. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: Composite International Diagnostic Interview-Short Form (CIDI-SF). NLM UID: 9502838.
KW - Health Services Accessibility
KW - Mental Disorders -- Rehabilitation
KW - Mental Health Services -- Utilization
KW - Substance Use Disorders -- Rehabilitation
KW - Adult
KW - Descriptive Statistics
KW - Diagnosis, Dual (Psychiatry)
KW - DSM
KW - P-Value
KW - Prospective Studies
KW - Psychological Tests
KW - Questionnaires
KW - Structured Interview
KW - Surveys
KW - Human
SP - 954
EP - 959
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 56
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVES: This study investigated patterns of use of mental health care and substance abuse treatment for a nationally representative sample of adults with co-occurring mental health problems and a substance use disorder and compared these patterns with those of persons with either a mental health problem or a substance use disorder. METHODS: Data were from the 2001 and 2002 National Surveys on Drug Use and Health. The study examined rates of substance use disorders and mental health problems among adults aged 18 years and older, rates of substance use disorders among adults with mental health problems, and rates of mental health problems among adults with substance use disorders. Next, rates of substance abuse treatment and mental health care use were calculated among five groups that were formed on the basis of the presence of a substance use disorder, mental health problems, or both in the past year. RESULTS: A total of 2,851 respondents had a substance use disorder only, 1,633 had a substance use disorder with one or more mental health symptoms and without serious mental illness, 1,872 had a substance use disorder with serious mental illness, 13,759 had one or more mental health symptoms only, and 7,530 had a serious mental illness only. A substantial proportion of adults with comorbid mental health problems and a substance use disorder did not receive any treatment (46 percent of those with serious mental illness and 65 percent of those with one or more mental health symptoms). Co-occurring substance use disorder was not associated with increased use of mental health care. The likelihood of receiving any substance abuse treatment increased with the presence and severity of mental health problems. Across all five groups, use of mental health care was more common than use of substance abuse treatment. Less than one-third of patients with comorbid mental health problems and a substance use disorder who used mental health care also received substance abuse treatment. CONCLUSIONS: The large proportion of untreated individuals with mental and substance use disorders reinforces existing concerns about barriers to beneficial treatment. Low rates of use of substance abuse treatment among patients who have comorbid mental health problems and a substance use disorder and use mental health care suggest that recommendations that substance use disorders be treated before, or concurrently with, mental disorders have not been widely adopted.
SN - 1075-2730
AD - Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16-105, Rockville, MD 20857; kharris@samhsa.gov
U2 - PMID: 16088012.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106373830&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shi, L.
AU - Macinko, J.
AU - Starfield, B.
AU - Politzer, R.
AU - Wulu, J.
AU - Xu, J.
T1 - Primary care, social inequalities and all-cause, heart disease and cancer mortality in US counties: a comparison between urban and non-urban areas.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2005/08//
VL - 119
IS - 8
M3 - Article
SP - 699
EP - 710
SN - 00333506
AB - Objective: The objective of this study was to test whether the association between primary care and income inequality on art-cause, heart disease and cancer mortality at county level differs in urban (Metropolitan Statistical Area-MSA) compared with non-urban (non-MSA) areas. Study design: The study consisted of a cross-sectional analysis of county-level data stratified by MSA and non-MSA areas in 1990. Dependent variables included age and sex-standardized (per 100,000) all-cause, heart disease and cancer mortality. Independent variables included primary care resources, income inequality, education levels, unemployment, racial/ethnic composition and income levels. Methods: One-way analysis of variance and multivariate ordinary least squares regression were employed for each health outcome. Results: Among non-MSA counties, those in the highest income inequality category experienced 11% higher air-cause mortality, 9% higher heart disease mortality, and 9% higher cancer mortality than counties in the lowest income inequality quartile, while controlling for other health determinants. Non-MSA counties with higher primary care experienced 2% lower all-cause mortality, 4% lower heart disease mortality, and 3% lower cancer mortality than non-MSA counties with lower primary care. MSA counties with median levels of income inequality experienced approximately 6% higher all-cause mortality, 7% higher heart disease mortality, and 7% higher cancer mortality than counties in the lowest income inequality quartile. MSA counties with low primary care (less than 75th percentile) had significantly lower levels of all-cause, heart disease and cancer mortality than those counties with high primary care. Conclusions: In non-MSA counties, increasing primary physician supply could be one way to address the health needs of rural populations. In MSA counties, the association between primary care and health outcomes appears to be more complex and is likely to require intervention that focuses on multiple fronts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health (Elsevier) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY care (Medicine)
KW - EQUALITY
KW - HEART diseases
KW - CANCER
KW - MORTALITY -- Statistics
KW - URBAN health
KW - U.S. states
KW - UNITED States
KW - Health inequalities
KW - Primary care
KW - Social epidemiology
KW - Urban health
N1 - Accession Number: 17707771; Shi, L. 1; Email Address: lshi@jhsph.edu Macinko, J. 2 Starfield, B. 1 Politzer, R. 3 Wulu, J. 3 Xu, J. 1; Affiliation: 1: Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Room 406, Baltimore, MD 21205, USA 2: Steinhardt School of Education, New York University, New York, NY, USA 3: Health Resources and Services Administration, Bureau for Primary Care, US Department of Health and Human Services, Rockville, MD, USA; Source Info: Aug2005, Vol. 119 Issue 8, p699; Subject Term: PRIMARY care (Medicine); Subject Term: EQUALITY; Subject Term: HEART diseases; Subject Term: CANCER; Subject Term: MORTALITY -- Statistics; Subject Term: URBAN health; Subject Term: U.S. states; Subject Term: UNITED States; Author-Supplied Keyword: Health inequalities; Author-Supplied Keyword: Primary care; Author-Supplied Keyword: Social epidemiology; Author-Supplied Keyword: Urban health; Number of Pages: 12p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1016/j.puhe.2004.12.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17707771&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Christie, S.
AU - Morgan, G.
AU - Heaven, M.
AU - Sandifer, Q.
AU - Van Woerden, H.
T1 - Analysis of renal service provision in south and mid Wales.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2005/08//
VL - 119
IS - 8
M3 - Article
SP - 738
EP - 742
SN - 00333506
AB - Objectives: This paper estimates point prevalence of renal replacement therapy (RRT) utilization within population strata defined by geography and deprivation in south and mid Wales. It investigates spatial accessibility of main and satellite renal units by comparing population and patient numbers within bands of travel time. Study design: Prevalence study based on patient registers. Methods: From a fist of patient and renal unit locations, geocoded at the level of unit postcodes, and electoral division-level denominator population data, we calculated RRT point prevalence for the 16 unitary authorities in the study area, fifths of small area deprivation, and three bands of travel time from the nearest main renal unit and any (main or satellite) unit. Results: Overall point prevalence was 633 per million population (pmp) and this varied from 256 to 780 pmp across unitary authorities. RRT prevalence was lower in more deprived areas. Sixty-nine percent of the population and 73% of patients lived within 30 min of a main renal unit. Eighty-four percent of the population and 88% of patients lived within 30 min of a main or satellite renal unit. Conclusions: The provision of satellite renal units has significantly improved spatial accessibility of RRT services. However, a substantial proportion of the population remains geographically distant from renal units. This has important implications for planning of future provision of RRT, given the inverse relationship between RRT acceptance and travel time, and the impact on quality of life of patients who travel frequently to renal units. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health (Elsevier) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODIALYSIS
KW - KIDNEYS -- Displacement
KW - SPATIAL ability
KW - SPATIAL analysis (Statistics)
KW - WALES
KW - Drive time
KW - Renal replacement therapy
KW - Spatial accessibility
KW - Wales
N1 - Accession Number: 17707776; Christie, S. 1; Email Address: stephen.christie@nphs.wales.nhs.uk Morgan, G. 1 Heaven, M. 1 Sandifer, Q. 1 Van Woerden, H. 1; Affiliation: 1: National Public Health Service for Wales, Mamhilad Park Estate, Pontypool, Wales NP4 0YP, UK; Source Info: Aug2005, Vol. 119 Issue 8, p738; Subject Term: HEMODIALYSIS; Subject Term: KIDNEYS -- Displacement; Subject Term: SPATIAL ability; Subject Term: SPATIAL analysis (Statistics); Subject Term: WALES; Author-Supplied Keyword: Drive time; Author-Supplied Keyword: Renal replacement therapy; Author-Supplied Keyword: Spatial accessibility; Author-Supplied Keyword: Wales; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph, 1 Map; Document Type: Article
L3 - 10.1016/j.puhe.2005.01.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17707776&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104741962
T1 - Analysis of renal service provision in south and mid Wales.
AU - Christie, S
AU - Morgan, G
AU - Heaven, M
AU - Sandifer, Q
AU - Woerden, H van
Y1 - 2005/08//
N1 - Accession Number: 104741962. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 0376507.
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Kidney Failure, Chronic -- Therapy
KW - Renal Replacement Therapy -- Utilization
KW - Geographic Factors
KW - Health Services Needs and Demand
KW - Human
KW - Kidney Failure, Chronic -- Epidemiology
KW - Data Collection
KW - Social Class
KW - Wales
SP - 738
EP - 742
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 119
IS - 8
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service for Wales, Mamhilad Park Estate, Pontypool, Wales NP4 0YP, UK. stephen.christie@nphs.wales.uk
U2 - PMID: 15949526.
DO - 10.1016/j.puhe.2005.01.013
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brynes, Steven D.
T1 - Demystifying 21 CFR Part 556—Tolerances for residues of new animal drugs in food
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/08//
VL - 42
IS - 3
M3 - Article
SP - 324
EP - 327
SN - 02732300
AB - Abstract: 21 Code of Federal Regulations Part 556 (Tolerances for Residues of New Animal Drugs in Foods) is one of the Center for Veterinary Medicine’s most significant set of regulations. However, in many respects, it is outdated. Subpart A (General Provisions) defines tolerance designations that are obsolete, while Subpart B (Specific Tolerances for Residues of New Animal Drugs) is inconsistent in terminology and often confusing. The purpose of this paper is to define the older terms and update the reader as to current concepts that apply to tolerance-setting for new animal drugs. A list of useful definitions appears at the end of the article. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animal diseases
KW - Drugs
KW - Health
KW - Animal health
KW - 21 CFR 556
KW - Animal drug residues
KW - Code of Federal Regulations
KW - Safe concentrations
KW - Tolerances
N1 - Accession Number: 18160311; Brynes, Steven D. 1; Email Address: sbrynes@cvm.fda.gov; Affiliations: 1: Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Aug2005, Vol. 42 Issue 3, p324; Thesaurus Term: Animal diseases; Thesaurus Term: Drugs; Thesaurus Term: Health; Subject Term: Animal health; Author-Supplied Keyword: 21 CFR 556; Author-Supplied Keyword: Animal drug residues; Author-Supplied Keyword: Code of Federal Regulations; Author-Supplied Keyword: Safe concentrations; Author-Supplied Keyword: Tolerances; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.05.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hong, H.
AU - Tong, W.
AU - Xie, Q.
AU - Fang, H.
AU - Perkins, R.
T1 - An in silico ensemble method for lead discovery: decision forest.
JO - SAR & QSAR in Environmental Research
JF - SAR & QSAR in Environmental Research
Y1 - 2005/08//
VL - 16
IS - 4
M3 - Article
SP - 339
EP - 347
SN - 1062936X
AB - Recent progress in combinatorial chemistry and parallel synthesis has radically changed the approach to drug discovery in the pharmaceutical industry. Al present, thousands of compounds can be made in a short period, creating a need for fast and effective in silico methods to select the most promising lead candidates. Decision forest is a novel pattern recognition method, which combines the results of multiple distinct but comparable decision tree models to reach a consensus prediction. In Ihis article, a decision forest model was developed using a structurally diverse training data set containing 232 compounds whose estrogen receptor binding activity was tested at the U.S. Food and Drug Administration (FDA)'s National Center for Toxicological Research (NCTR). The model was subsequently validated using a test data set of 463 compounds selected from the literature, and then applied to a large data set with 57,145 compounds as a screening example. The results show that the decision forest method is a fast, reliable and effective in silico approach, which could be useful in drug discovery. [ABSTRACT FROM AUTHOR]
AB - Copyright of SAR & QSAR in Environmental Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMBINATORIAL chemistry
KW - PHARMACOLOGY
KW - PHARMACEUTICAL industry
KW - BIOACTIVE compounds
KW - BINDING sites (Biochemistry)
KW - Classification
KW - Decision forest
KW - Estrogen binding
KW - Lead discovery
KW - QSAR
N1 - Accession Number: 18586917; Hong, H. 1 Tong, W. 2; Email Address: wtong@nctr.fda.gov Xie, Q. 1 Fang, H. 1 Perkins, R. 1; Affiliation: 1: Division of Bioinformatics, Z-Tech at National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Division of Systems Toxicology, Center for Toxicoinformatics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Aug2005, Vol. 16 Issue 4, p339; Subject Term: COMBINATORIAL chemistry; Subject Term: PHARMACOLOGY; Subject Term: PHARMACEUTICAL industry; Subject Term: BIOACTIVE compounds; Subject Term: BINDING sites (Biochemistry); Author-Supplied Keyword: Classification; Author-Supplied Keyword: Decision forest; Author-Supplied Keyword: Estrogen binding; Author-Supplied Keyword: Lead discovery; Author-Supplied Keyword: QSAR; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1080/10659360500203022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Training the Shoulder Complex in Baseball Pitchers: A Sport-Specific Approach.
AU - Jeran, Jeffrey J.
AU - Chetlin, Robert D.
JO - Strength & Conditioning Journal (Allen Press)
JF - Strength & Conditioning Journal (Allen Press)
Y1 - 2005/08//
VL - 27
IS - 4
SP - 14
EP - 31
SN - 15241602
N1 - Accession Number: 17875331; Author: Jeran, Jeffrey J.: 1 Author: Chetlin, Robert D.: 2 ; Author Affiliation: 1 National Institute of Occupational Safety and Health Wellness Center, Morgantown, West Virginia: 2 West Virginia University School of Medicine, Morgantown, West Virginia; No. of Pages: 18; Language: English; Publication Type: Article; Update Code: 20050811
N2 - The purpose of this paper is to identify exercise performance-related factors which may contribute to shoulder pain and dysfunction and to describe appropriate training strategies for promoting shoulder stability and enhanced function. The intent is not to help the reader diagnose and treat injuries or to prescribe therapeutic interventions. Strength and conditioning professionals should encourage injured clients to consult a physician, physical therapist, or other appropriate health care professional before starting a conditioning program. ABSTRACT FROM AUTHOR
KW - *SHOULDER pain
KW - *SHOULDER exercises
KW - *BASEBALL injuries
KW - *BASEBALL players
KW - *EXERCISE therapy
KW - baseball
KW - exercise
KW - pitchers
KW - shoulder
KW - training
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106518697
T1 - Training the shoulder complex in baseball pitchers: a sport-specific approach [corrected] [published erratum appears in STRENGTH CONDITION J 2007 Apr;29(2):80].
AU - Jeran JJ
AU - Chetlin RD
Y1 - 2005/08//
N1 - Accession Number: 106518697. Language: English. Entry Date: 20050930. Revision Date: 20150818. Publication Type: Journal Article; pictorial; review; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 100888833.
KW - Baseball
KW - Throwing
KW - Sport Specific Training
KW - Athletic Training -- Methods
KW - Shoulder
KW - Exercise Physiology
KW - Shoulder -- Anatomy and Histology
KW - Shoulder -- Physiology
KW - Biophysics
KW - Biomechanics
KW - Athletic Injuries -- Prevention and Control
KW - Muscle Strengthening -- Equipment and Supplies
SP - 14
EP - 31
JO - Strength & Conditioning Journal (Allen Press)
JF - Strength & Conditioning Journal (Allen Press)
JA - STRENGTH CONDITION J
VL - 27
IS - 4
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - The purpose of this paper is to identify exercise performance-related factors which may contribute to shoulder pain and dysfunction and to describe appropriate training strategies for promoting shoulder stability and enhanced function. The intent is not to help the reader diagnose and treat injuries or to prescribe therapeutic interventions. Strength and conditioning professionals should encourage injured clients to consult a physician, physical therapist, or other appropriate health care professional before starting a conditioning program.
SN - 1524-1602
AD - National Institute of Occupational Safety and Health Wellness Center, Morgantown, WV
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106518697&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Jong Kwon
AU - Byun, Jung A
AU - Park, Seung Hee
AU - Choi, Han Jin
AU - Kim, Hyung Soo
AU - Oh, Hye Young
T1 - Evaluation of the potential immunotoxicity of 3-monochloro-1,2-propanediol in Balb/c mice: II. Effect on thymic subset, delayed-type hypersensitivity, mixed-lymphocyte reaction, and peritoneal macrophage activity
JO - Toxicology
JF - Toxicology
Y1 - 2005/08//
VL - 211
IS - 3
M3 - Article
SP - 187
EP - 196
SN - 0300483X
AB - Abstract: 3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. To evaluate the immunotoxicity of MCPD, we investigated its effect on the thymic subset, delayed-type hypersensitivity, mixed-lymphocyte reaction and peritoneal macrophage activity. MCPD was administered by gavage for 14 days at 0, 25, 50, and 100mg/kg/day to female Balb/c mice. The thymic subsets and annexin-V positive cells in thymic cells were quantified by flow cytometry. Mixed-lymphocyte reaction, delayed-type hypersensitivity and peritoneal macrophage activity were assessed. The mixed-lymphocyte reaction and delayed-type hypersensitivity were not significantly changed. However, there were significant increases in the apoptosis of mice treated with high dose of MCPD compared to the vehicle control. A significant decrease in the CD4+CD8+ thymic subset of mice treated with high dose of MCPD was observed. The activity of peritoneal macrophage was significantly reduced in high dose group. These results indicate that MCPD could modulate the immune function in Balb/c mice. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CELL death
KW - ALLERGY
KW - CELLS
KW - SOY sauce manufacturing
KW - Apoptosis
KW - Immunotoxicity
KW - Macrophage activity
KW - MCPD
KW - Thymic subsets
N1 - Accession Number: 18481444; Lee, Jong Kwon; Email Address: jkleest@hanmail.net Byun, Jung A 1 Park, Seung Hee 1 Choi, Han Jin 1 Kim, Hyung Soo 1 Oh, Hye Young 1; Affiliation: 1: Division of Immunotoxicology, National Institute of Toxicology Research, Korea Food and Drug Administration, 122-704 Seoul, South Korea; Source Info: Aug2005, Vol. 211 Issue 3, p187; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: ALLERGY; Subject Term: CELLS; Subject Term: SOY sauce manufacturing; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Macrophage activity; Author-Supplied Keyword: MCPD; Author-Supplied Keyword: Thymic subsets; NAICS/Industry Codes: 311941 Mayonnaise, Dressing, and Other Prepared Sauce Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.tox.2005.03.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18481444&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guo, T.L.
AU - Germolec, D.R.
AU - Musgrove, D.L.
AU - Delclos, K.B.
AU - Newbold, R.R.
AU - Weis, C.
AU - White, K.L.
T1 - Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague–Dawley rats following developmental and adult exposures
JO - Toxicology
JF - Toxicology
Y1 - 2005/08//
VL - 211
IS - 3
M3 - Article
SP - 207
EP - 219
SN - 0300483X
AB - Abstract: The myelotoxicity of five endocrine active chemicals was evaluated in F1 generation of Sprague–Dawley rats following developmental and adult exposures at three concentration levels. Rats were exposed to genistein (GEN: 25, 250 and 1250ppm), nonylphenol (NPH: 25, 500 and 2000ppm), methoxychlor (MXC: 10, 100 and 1000ppm), vinclozolin (VCZ: 10, 150 and 750ppm) and ethinyl estradiol (EE2: 5, 25 and 200ppb) gestationally and lactationally through dams from day 7 of gestation and through feed after weaning on postnatal day (PND) 22 to PND 64. The parameters examined included the number of recovered bone marrow cells, DNA synthesis, and colony forming units (CFU) in the presence of granulocyte macrophage-colony stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and erythropoietin. Except for the EE2, the concentrations of other individual chemicals in the diet were in an approximate range that allowed for a comparison to be made in terms of myelotoxic potency. Decreases in the DNA synthesis, CFU-GM and CFU-M seemed to be the common findings among the alterations induced by these compounds. Using the numbers of alterations induced by each chemical in the parameters examined as criteria for comparison, the order of myelotoxic potency in F1 males was: GEN>MXC>NPH>VCZ; the order in females: GEN>NPH>VCZ. Additionally, some of the functional changes induced by these compounds were gender-specific or dimorphic. Overall, the results demonstrated that developmental and adult exposures of F1 rats to these endocrine active chemicals at the concentrations tested had varied degrees of myelotoxicity with GEN being the most potent. Furthermore, the sex-specific effects of these chemicals in F1 male and female rats suggest that there may be interactions between these compounds and sex hormone in modulating these responses. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STEROID hormones
KW - CHEMICAL terrorism
KW - BONE marrow
KW - BONE marrow cells
KW - DNA
KW - Endocrine active chemicals
KW - Ethinyl estradiol
KW - Genistein
KW - Methoxychlor and developmental myelotoxicity
KW - Nonylphenol
KW - Vinclozolin
N1 - Accession Number: 18481446; Guo, T.L. 1; Email Address: tlguo@hsc.vcu.edu Germolec, D.R. 2 Musgrove, D.L. 1 Delclos, K.B. 3 Newbold, R.R. 2 Weis, C. 3 White, K.L. 1; Affiliation: 1: Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298-0613, USA 2: Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Aug2005, Vol. 211 Issue 3, p207; Subject Term: STEROID hormones; Subject Term: CHEMICAL terrorism; Subject Term: BONE marrow; Subject Term: BONE marrow cells; Subject Term: DNA; Author-Supplied Keyword: Endocrine active chemicals; Author-Supplied Keyword: Ethinyl estradiol; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Methoxychlor and developmental myelotoxicity; Author-Supplied Keyword: Nonylphenol; Author-Supplied Keyword: Vinclozolin; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.tox.2005.03.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18481446&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-13824-023
AN - 2005-13824-023
AU - Leonardson, Gary R.
AU - Kemper, Erica
AU - Ness, Frederick K.
AU - Koplin, Brett A.
AU - Daniels, Mark C.
AU - Leonardson, Greg A.
T1 - Validity and reliability of the AUDIT and CAGE-AID in Northern Plains American Indians.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 2005/08//
VL - 97
IS - 1
SP - 161
EP - 166
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
AD - Leonardson, Gary R., 55 Rodeo Trail, Dillon, MT, US, 59725
N1 - Accession Number: 2005-13824-023. PMID: 16279320 Partial author list: First Author & Affiliation: Leonardson, Gary R.; Mountain Plains Research, Dillon, MT, US. Other Publishers: Sage Publications. Release Date: 20051219. Correction Date: 20120917. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Diabetes; Drug Abuse; Primary Health Care; Screening Tests. Minor Descriptor: Health; Test Reliability; Test Validity. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Alcohol Use Disorders Identification Test DOI: 10.1037/t01528-000; Beck Depression Inventory–II DOI: 10.1037/t00742-000; General Well-Being Schedule DOI: 10.1037/t04083-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Aug, 2005.
AB - According to the Indian Health Service, substance abuse and Type 2 diabetes are serious problems among Native Americans. To assess substance use in a medical setting, valid screening tests are needed so the Alcohol Use Disorders Identification Test (AUDIT), a simple brief screen for excessive drinking, and the CAGE-adapted to include Drugs (CAGE-AID) for identifying primary care patients with alcohol and drug disorders were given 50 Northern Plains American Indians with diabetes. Both are short, easy to administer, have good sensitivity and specificity, and can be easily incorporated into a medical history protocol or intake procedure. Reliability coefficients were above .90 and appeared to have sufficient concurrent and divergent validity indicated by moderate correlations with the General Well-being Schedule (rs = -.39 and -.36), the Family-Adaptation, Partnership, Growth, Affection, & Resolve (r = -47 and -.36), and the Beck Depression Inventory-II (r = .36 and .29). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indians
KW - Native Americans
KW - test validity
KW - test reliability
KW - Alcohol Use Disorders Identification Test
KW - CAGE adaptation
KW - substance abuse
KW - diabetes
KW - screening tests
KW - 2005
KW - American Indians
KW - Diabetes
KW - Drug Abuse
KW - Primary Health Care
KW - Screening Tests
KW - Health
KW - Test Reliability
KW - Test Validity
KW - 2005
DO - 10.2466/PR0.97.5.161-166
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13824-023&site=ehost-live&scope=site
UR - mpr@bmt.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09115-001
AN - 2005-09115-001
AU - Evans, Dwight L.
AU - Charney, Dennis S.
AU - Lewis, Lydia
AU - Golden, Robert N.
AU - Gorman, Jack M.
AU - Krishnan, K. Ranga Rama
AU - Nemeroff, Charles B.
AU - Bremner, J. Douglas
AU - Carney, Robert M.
AU - Coyne, James C.
AU - Delong, Mahlon R.
AU - Frasure-Smith, Nancy
AU - Classman, Alexander H.
AU - Gold, Philip W.
AU - Grant, Igor
AU - Gwyther, Lisa
AU - Ironson, Gail
AU - Johnson, Robert L.
AU - Kanner, Andres M.
AU - Katon, Wayne J.
AU - Kaufmann, Peter G.
AU - Keefe, Francis J.
AU - Ketter, Terence
AU - Laughren, Thomas P.
AU - Leserman, Jane
AU - Lyketsos, Constantine G.
AU - McDonald, William M.
AU - McEwen, Bruce S.
AU - Miller, Andrew H.
AU - Musselman, Dominique
AU - O'Connor, Christopher
AU - Petitto, John M.
AU - Pollock, Bruce G.
AU - Robinson, Robert G.
AU - Roose, Steven P.
AU - Rowland, Julia
AU - Sheline, Yvette
AU - Sheps, David S.
AU - Simon, Gregory
AU - Spiegel, David
AU - Stunkard, Albert
AU - Sunderland, Trey
AU - Tibbits, Paul Jr.
AU - Valvo, William J.
T1 - Mood Disorders in the Medically Ill: Scientific Review and Recommendations.
JF - Biological Psychiatry
JO - Biological Psychiatry
JA - Biol Psychiatry
Y1 - 2005/08//
VL - 58
IS - 3
SP - 175
EP - 189
CY - Netherlands
PB - Elsevier Science
SN - 0006-3223
AD - Evans, Dwight L., University of Pennsylvania School of Medicine, Department of Psychiatry, 305 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, US, 19104
N1 - Accession Number: 2005-09115-001. PMID: 16084838 Partial author list: First Author & Affiliation: Evans, Dwight L.; University of Pennsylvania, Philadelphia, PA, US. Release Date: 20050906. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Comorbidity; Death and Dying; Physical Disorders; Risk Factors. Minor Descriptor: Diagnosis; Disease Course; Epidemiology; Major Depression; Primary Health Care. Classification: Affective Disorders (3211); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 15. Issue Publication Date: Aug, 2005.
AB - Objective: The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research. Data Sources: Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors. Study Selection/Data Extraction: Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized, controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed. Conclusions: A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mood disorders
KW - medical illness
KW - comorbidities
KW - risk factors
KW - mortality
KW - morbidity
KW - disease course
KW - 2005
KW - Affective Disorders
KW - Comorbidity
KW - Death and Dying
KW - Physical Disorders
KW - Risk Factors
KW - Diagnosis
KW - Disease Course
KW - Epidemiology
KW - Major Depression
KW - Primary Health Care
KW - 2005
DO - 10.1016/j.biopsych.2005.05.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09115-001&site=ehost-live&scope=site
UR - psych@mail.med.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08794-005
AN - 2005-08794-005
AU - Iida, Elizabeth E.
AU - Springer, J. Fred
AU - Pecora, Peter J.
AU - Bandstra, Emmalee S.
AU - Edwards, Mark C.
AU - Basen, Michele M.
T1 - The SESS multisite collaborative research initiative: Establishing common ground.
JF - Child & Family Social Work
JO - Child & Family Social Work
JA - Child Fam Soc Work
Y1 - 2005/08//
VL - 10
IS - 3
SP - 217
EP - 228
CY - United Kingdom
PB - Blackwell Publishing
SN - 1356-7500
SN - 1365-2206
AD - Iida, Elizabeth E., 1913 Magdalena Circle, No. 107, Santa Clara, CA, US, 95051
N1 - Accession Number: 2005-08794-005. Partial author list: First Author & Affiliation: Iida, Elizabeth E.; Asian American Recovery Services, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20050815. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Early Intervention; Government Programs; Health Service Needs; Interdisciplinary Treatment Approach; Parental Characteristics. Minor Descriptor: At Risk Populations; Drug Abuse; Integrated Services; Mental Disorders; Mental Health Services; Parent Child Relations; Primary Health Care. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 12. Issue Publication Date: Aug, 2005.
AB - Multidisciplinary intervention approaches are needed for meeting service needs for families in which substance abuse and mental health disorders may be interfering with child-rearing. Experiences from the Starting Early Starting Smart (SESS) initiative, a 12-site national collaborative investigation of integrating behavioral health services in early childhood and primary health care service settings for children aged 0-5 years and their families and caregivers, are described. This 4-year applied research initiative was co-funded by the Substance Abuse and Mental Health Services Administration of the US Department of Health and Human Services and Casey Family Programs, a private operating foundation. SESS, which was developed and implemented in 12 geographically and culturally diverse cities in the USA during 1997-2001, encouraged federal, state, and local public/private partnerships. Opportunities and challenges in using an inclusive, consensus-based, stakeholder model to maximize study relevance and utility for researchers, practitioners, and fiscal sponsors are discussed, and lessons for multidisciplinary, multisite research collaborations are identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health service needs
KW - multidisciplinary intervention approach
KW - families
KW - at risk children
KW - collaboration
KW - Starting Early Starting Smart initiative
KW - primary health care
KW - child rearing
KW - 2005
KW - Early Intervention
KW - Government Programs
KW - Health Service Needs
KW - Interdisciplinary Treatment Approach
KW - Parental Characteristics
KW - At Risk Populations
KW - Drug Abuse
KW - Integrated Services
KW - Mental Disorders
KW - Mental Health Services
KW - Parent Child Relations
KW - Primary Health Care
KW - 2005
DO - 10.1111/j.1365-2206.2005.00377.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08794-005&site=ehost-live&scope=site
UR - eeiida@sbcglobal.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10741-012
AN - 2005-10741-012
AU - Ferguson, Sherry A.
AU - Gray, Erika P.
T1 - Aging effects on elevated plus maze behavior in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley male and female rats.
JF - Physiology & Behavior
JO - Physiology & Behavior
JA - Physiol Behav
Y1 - 2005/08//
VL - 85
IS - 5
SP - 621
EP - 628
CY - Netherlands
PB - Elsevier Science
SN - 0031-9384
AD - Ferguson, Sherry A., Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2005-10741-012. PMID: 16043200 Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20051003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Animal Locomotion; Hypertension; Mazes; Rats. Minor Descriptor: Animal Sex Differences; Animal Strain Differences; Anxiety; Behavior Change. Classification: Physiological Processes (2540). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2005.
AB - Male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats were assessed at one of two ages (postnatal day 74 or 346) for open field locomotor activity and anxiety-related behavior in the elevated plus maze (EPM). In general, the SHR displayed the least anxiety-related behavior, an effect that was magnified with age. At 11 months of age, the SHR more frequently entered and remained longer in the open arms than either the SD or the WKY strains. EPM behavior of the WKY strain was much less affected by age than that of the SD strain which displayed increased anxiety-related behavior with age. At the younger age, the typical sex effects were apparent; specifically, females exhibited a shorter duration in the closed arms. While the SHR were the most active strain in the EPM at both ages, they were more active in the open field only at the older age. In general, age-related changes in open field activity mirrored those of the EPM. These results provide a more comprehensive illustration of aging-related behavioral changes in male and female SHR, WKY and SD rats. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - aging
KW - elevated plus maze behavior
KW - hypertensivity
KW - locomotor activity
KW - anxiety behavior
KW - rats
KW - behavioral change
KW - gender differencess
KW - strain differences
KW - 2005
KW - Aging
KW - Animal Locomotion
KW - Hypertension
KW - Mazes
KW - Rats
KW - Animal Sex Differences
KW - Animal Strain Differences
KW - Anxiety
KW - Behavior Change
KW - 2005
DO - 10.1016/j.physbeh.2005.06.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10741-012&site=ehost-live&scope=site
UR - sferguson@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-08179-002
AN - 2005-08179-002
AU - Harris, Katherine M.
AU - Edlund, Mark J.
AU - Larson, Sharon
T1 - Racial and Ethnic Differences in the Mental Health Problems and Use of Mental Health Care.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2005/08//
VL - 43
IS - 8
SP - 775
EP - 784
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Harris, Katherine M., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16105, Rockville, MD, US, 20856
N1 - Accession Number: 2005-08179-002. PMID: 16034291 Partial author list: First Author & Affiliation: Harris, Katherine M.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20051219. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Health Care Utilization; Mental Disorders; Mental Health Services; Racial and Ethnic Differences. Minor Descriptor: Mental Health; Racial and Ethnic Groups. Classification: Health & Mental Health Services (3370); Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 2005.
AB - Objectives: We compared rates of mental health problems and use of mental health care across multiple racial and ethnic groups using secondary data from a large, nationally representative survey. Methods: We pooled cross-sectional data from the 2001-2003 National Surveys on Drug Use and Health. Our sample included 134,875 adults classified as white, African American, American Indian/Alaskan Native, Asian, Mexican, Central and South American, Puerto Rican, other Hispanic-Latino, or those with multiple race and ethnicities. For each group, we estimate the past year probability of: (1) having 1 or more mental health symptoms in the past year, (2) having serious mental illness in the past year, (3) using mental health care, (4) using mental health care conditional on having mental health problems, (5) reporting unmet need for mental health care, and (6) reporting unmet need for mental health care conditional on having mental health problems. Results: We found significantly higher rates of mental health problems and higher self-reported unmet need relative to whites among American Indian/Alaskan Natives and lower rates of mental health problems and use of mental health care among African American, Asian, Mexican, Central and South American, and other Hispanic-Latino groups. These differences generally were robust to the inclusion of clinical and socio demographic covariates. Conclusions: Overall, our study shows wide variation in mental health morbidity and use of mental health care across racial and ethnic groups in the United States. These results can help to focus efforts aimed at understanding the underlying causes of the differences we observe. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health morbidity
KW - mental health care utilization
KW - racial differences
KW - ethnic differences
KW - 2005
KW - Epidemiology
KW - Health Care Utilization
KW - Mental Disorders
KW - Mental Health Services
KW - Racial and Ethnic Differences
KW - Mental Health
KW - Racial and Ethnic Groups
KW - 2005
DO - 10.1097/01.mlr.0000170405.66264.23
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-08179-002&site=ehost-live&scope=site
UR - kharris@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09093-007
AN - 2005-09093-007
AU - Harris, Katherine M.
AU - Edlund, Mark J.
T1 - Use of Mental Health Care and Substance Abuse Treatment Among Adults With Co-occurring Disorders.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/08//
VL - 56
IS - 8
SP - 954
EP - 959
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Harris, Katherine M., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Room 16-105, Rockville, MD, US, 20857
N1 - Accession Number: 2005-09093-007. PMID: 16088012 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Harris, Katherine M.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20050906. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Health Care Delivery; Mental Disorders; Mental Health Services. Minor Descriptor: Substance Use Disorder. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: National Surveys on Drug Use and Health; Composite International Diagnostic Interview-Short Form. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Aug, 2005.
AB - Objectives: This study investigated patterns of use of mental health care and substance abuse treatment for a nationally representative sample of adults with co-occurring mental health problems and a substance use disorder and compared these patterns with those of persons with either a mental health problem or a substance use disorder. Methods: Data were from the 2001 and 2002 National Surveys on Drug Use and Health. The study examined rates of substance use disorders and mental health problems among adults aged 18 years and older, rates of substance use disorders among adults with mental health problems, and rates of mental health problems among adults with substance use disorders. Next, rates of substance abuse treatment and mental health care use were calculated among five groups that were formed on the basis of the presence of a substance use disorder, mental health problems, or both in the past year. Results: A total of 2,851 respondents had a substance use disorder only, 1,633 had a substance use disorder with one or more mental health symptoms and without serious mental illness, 1,872 had a substance use disorder with serious mental illness, 13,759 had one or more mental health symptoms only, and 7,530 had a serious mental illness only. A substantial proportion of adults with comorbid mental health problems and a substance use disorder did not receive any treatment (46 percent of those with serious mental illness and 65 percent of those with one or more mental health symptoms). Co-occurring substance use disorder was not associated with increased use of mental health care. The likelihood of receiving any substance abuse treatment increased with the presence and severity of mental health problems. Across all five groups, use of mental health care was more common than use of substance abuse treatment. Less than one-third of patients with comorbid mental health problems and a substance use disorder who used mental health care also received substance abuse treatment. Conclusions: The large proportion of untreated individuals with mental and substance use disorders reinforces existing concerns about barriers to beneficial treatment. Low rates of use of substance abuse treatment among patients who have comorbid mental health problems and a substance use disorder and use mental health care suggest that recommendations that substance use disorders be treated before, or concurrently with, mental disorders have not been widely adopted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - substance abuse treatment
KW - mental illness
KW - cooccurring disorders
KW - mental health symptoms
KW - substance use disorder
KW - 2005
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Delivery
KW - Mental Disorders
KW - Mental Health Services
KW - Substance Use Disorder
KW - 2005
DO - 10.1176/appi.ps.56.8.954
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09093-007&site=ehost-live&scope=site
UR - kharris@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-14480-001
AN - 2005-14480-001
AU - Hsiao, Hongwei
AU - Simeonov, Peter
AU - Dotson, Brian
AU - Ammons, Douglas
AU - Kau, Tsui-Ying
AU - Chiou, Sharon
T1 - Human responses to augmented virtual scaffolding models.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2005/08//
VL - 48
IS - 10
SP - 1223
EP - 1242
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Hsiao, Hongwei, Protective Technology Branch, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2005-14480-001. PMID: 16253942 Partial author list: First Author & Affiliation: Hsiao, Hongwei; Protective Technology Branch, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20060123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Tactual Perception; Virtual Reality; Walking. Classification: Engineering & Environmental Psychology (4000). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Aug, 2005.
AB - This study investigated the effect of adding real planks, in virtual scaffolding models of elevation, on human performance in a surround-screen virtual reality (SSVR) system. Twenty-four construction workers and 24 inexperienced controls performed walking tasks on real and virtual planks at three virtual heights (0, 6 m, 12 m) and two scaffolding-platform-width conditions (30, 60 cm). Gait patterns, walking instability measurements and cardiovascular reactivity were assessed. The results showed differences in human responses to real vs. virtual planks in walking patterns, instability score and heart-rate inter-beat intervals; it appeared that adding real planks in the SSVR virtual scaffolding model enhanced the quality of SSVR as a human-environment interface research tool. In addition, there were significant differences in performance between construction workers and the control group. The inexperienced participants were more unstable as compared to construction workers. Both groups increased their stride length with repetitions of the task, indicating a possibly confidence- or habit-related learning effect. The practical implications of this study are in the adoption of augmented virtual models of elevated construction environments for injury prevention research, and the development of programme for balance-control training to reduce the risk of falls at elevation before workers enter a construction job. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human responses
KW - virtual scaffolding models
KW - tactile augmentation
KW - 2005
KW - Tactual Perception
KW - Virtual Reality
KW - Walking
KW - 2005
DO - 10.1080/00140130500197112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-14480-001&site=ehost-live&scope=site
UR - hhsiao@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Scavini, Marina
AU - Shah, Vallabh O.
AU - Stidley, Christine A.
AU - Tentori, Francesca
AU - Paine, Susan S.
AU - Harford, Antonia M.
AU - Narva, Andrew S.
AU - Kessler, David S.
AU - Bobelu, Arlene
AU - Albert, Carleton P.
AU - Bobelu, Jeanette
AU - Jamon, Eunice
AU - Natachu, Kathy
AU - Neha, Donica
AU - Welty, Thomas K.
AU - MacCluer, Jean W.
AU - Zager, Philip G.
T1 - Kidney disease among the Zuni Indians: The Zuni Kidney Project.
JO - Kidney International Supplement
JF - Kidney International Supplement
Y1 - 2005/08/02/
IS - 97
M3 - Article
SP - S126
EP - S131
SN - 00986577
AB - Kidney disease among the Zuni Indians: The Zuni Kidney Project. Background. There is an epidemic of kidney disease among the Zuni Indians. In collaboration with health care providers and research institutions, the Zuni Pueblo established the Zuni Kidney Project to reduce the burden of kidney disease. Methods. The Zuni Kidney Project conducted a population-based, cross-sectional survey to estimate the prevalence of albuminuria, hematuria, and related risk factors. Neighborhood household clusters served as the sampling frame. Participants completed a questionnaire, donated blood and urine samples, and had blood pressure, height, and weight measured. This survey provided the foundation for ongoing studies to identify genetic and environmental risk factors for disease susceptibility and progression. Results. Age and gender distributions among survey participants were similar to those in the eligible Zuni population. Prevalence of incipient albuminuria (IA) (0.03≤ urine albumin:creatinine ratio, UACR <0.3) and overt albuminuria (OA) (UACR <0.3) were higher among diabetics [IA 34.3% (28.3, 40.4%); OA 18.6% (13.7, 23.6%)] than nondiabetics [IA 11.1% (9.3, 12.8%); OA 1.7% (1.0, 2.5%)]. Nondiabetics comprised 58.6% (52.2, 65.0%) and 30.9% (19.9, 41.9%) of participants with IA and OA, respectively. The prevalence of hematuria was higher among diabetics [≥ trace 47.0% (40.7, 53.4); ≥50 red blood cell/μL 25.8% (20.3, 31.4%)] than nondiabetics [≥ trace 31.1% (28.5, 33.7%); ≥50 red blood cell/μL 16.6% (14.5, 18.7%)]. Hypertension was associated with albuminuria among diabetic and nondiabetic participants. Hypercholesterolemia was associated with albuminuria among nondiabetic participants. Diabetes and alcohol use were associated with hematuria. Conclusion. The high prevalences of albuminuria among nondiabetics and of hematuria among diabetics and nondiabetics are consistent with high rates of nondiabetic kidney disease among Zuni Indians with and without diabetes. (English) [ABSTRACT FROM AUTHOR]
AB - Antecedentes. Existe una epidemia de enfermedad renal en la etnia Zuni. En colaboración con los proveedores de salud y con centros de investigación, el Pueblo Zuni estableció el Proyecto Renal Zuni (PRZ), con el objetivo de disminuir la prevalencia de la enfermedad renal. Métodos. El PRZ condujo un estudio transversal para estimar la prevalencia de albuminuria, hematuria y los factores de riesgo asociados a enfermedad renal en esta población. Los participantes llenaron un cuestionario, aportaron muestras de sangre y orina y registraron su peso, estatura y presión arterial. La encuesta aportó las bases para estudios concurrentes encaminados a identificar factores de riesgo genéticos y ambientales que influyen en la susceptibilidad y avance de la enfermedad renal. Resultados. La distribución por edad y sexo en el grupo de estudio fue similar a la de la población Zuni elegible. La prevalencia de albuminuria incipiente (AI) (0.03 ≤ razón albumina:creatinina urinaria, RACR < 0.3) y albuminuria franca (AF) (RACR ≥ 0.3) fueron más altas en los diabéticos [AI: 34.3% (28.3, 40.4%); AF: 18.6% (13.7, 23.6%) que en los no diabéticos [AI: 11.1% (9.3, 12.8%); AF: 1.7%, (1.0, 2.5%)]. Los no diabéticos representaron el 58.6% (52.2, 65.0%) y el 30.9% (19.9, 41.9%) de los participantes con AI y AF, respectivamente. La prevalencia de hematuria fue más alta entre los diabéticos [≥ trazas: 47.0% (40.7, 53.4%) ≥ 50 eritrocitos/μL: 25.8% (20.3, 31.4%)] que entre los no diabéticos [≥ trazas: 31.1% (28.5, 33.7%) ≥ 50 eritrocitos/μL: 16.6% (14.5, 18.7%)]. La hipertensión se asoció con albuminuria en ambos grupos. Hipercolesterolemia se asoció con albuminuria entre los participantes no diabéticos. Tanto diabetes como la ingesta de alcohol se asociaron con hematuria. Conclusion. Tanto la elevada prevalencia de albuminuria entre los no diabéticos, como la de hematuria entre diabéticos y no diabéticos, son consistentes con las altas tasas de enfermedad renal no diabética observadas entre la población diabética y no diabética de la etnia Zuni. (Spanish) [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International Supplement is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINALYSIS
KW - KIDNEY diseases
KW - ALBUMINURIA
KW - ACUTE kidney failure
KW - ALPORT'S syndrome
KW - ZUNI (North American people)
KW - albuminuria
KW - American Indians
KW - diabetic and nondiabetic kidney disease
KW - epidemiology
KW - hematuria
KW - hypercholesterolemia
KW - hypertension
KW - obesity
KW - proteinuria
KW - risk factors
N1 - Accession Number: 17550980; Scavini, Marina 1,2,3,4,5,6,7,8 Shah, Vallabh O. 1,2,3,4,5,6,7,8 Stidley, Christine A. 1,2,3,4,5,6,7,8 Tentori, Francesca 1,2,3,4,5,6,7,8 Paine, Susan S. 1,2,3,4,5,6,7,8 Harford, Antonia M. 1,2,3,4,5,6,7,8 Narva, Andrew S. 1,2,3,4,5,6,7,8 Kessler, David S. 1,2,3,4,5,6,7,8 Bobelu, Arlene 1,2,3,4,5,6,7,8 Albert, Carleton P. 1,2,3,4,5,6,7,8 Bobelu, Jeanette 1,2,3,4,5,6,7,8 Jamon, Eunice 1,2,3,4,5,6,7,8 Natachu, Kathy 1,2,3,4,5,6,7,8 Neha, Donica 1,2,3,4,5,6,7,8 Welty, Thomas K. 1,2,3,4,5,6,7,8 MacCluer, Jean W. 1,2,3,4,5,6,7,8 Zager, Philip G. 1,2,3,4,5,6,7,8; Email Address: pzag@unm.edu; Affiliation: 1: Dialysis Clinic, Inc., Albuquerque, New Mexico. 2: Scientific Institute H San Raffaele, Milano, Italy. 3: Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico. 4: Department of Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico. 5: Indian Health Service, Kidney Disease Program, Albuquerque, New Mexico. 6: Zuni PHS Hospital, Zuni, New Mexico. 7: Southwest Foundation for Biomedical Research, San Antonio, Texas. 8: University of Milano, Milano, Italy.; Source Info: Aug2005, Issue 97, pS126; Subject Term: URINALYSIS; Subject Term: KIDNEY diseases; Subject Term: ALBUMINURIA; Subject Term: ACUTE kidney failure; Subject Term: ALPORT'S syndrome; Subject Term: ZUNI (North American people); Author-Supplied Keyword: albuminuria; Author-Supplied Keyword: American Indians; Author-Supplied Keyword: diabetic and nondiabetic kidney disease; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hematuria; Author-Supplied Keyword: hypercholesterolemia; Author-Supplied Keyword: hypertension; Author-Supplied Keyword: obesity; Author-Supplied Keyword: proteinuria; Author-Supplied Keyword: risk factors; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1523-1755.2005.09721.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17550980&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Yu-Ping
AU - Yan, Jian
AU - Beger, Richard D.
AU - Fu, Peter P.
AU - Chou, Ming W.
T1 - Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2005/08/08/
VL - 226
IS - 1
M3 - Article
SP - 27
EP - 35
SN - 03043835
AB - Abstract: Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/−)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetyleandomycin, a P450 3A enzyme inhibitor, reduced the formation of DHP by 52% and monocrotaline N-oxide formation by 59%. Dexamethasone significantly induced microsomal monocrotaline metabolizing enzyme activities in rat liver and lung. Previously, we have identified a set of DHP-derived DNA adducts from DHP-modified calf thymus DNA by 32P-post labeling/HPLC analysis. Metabolism of monocrotaline in the presence of calf thymus DNA resulted in a similar set of DHP–DNA adducts. These DHP–DNA adducts were also found in the liver DNA of rats treated with monocrotaline. The time course of the DHP-derived DNA adduct formation and removal in the liver of rats gavaged with a single dose (10mg/kg) of monocrotaline was similar to that of rats treated with riddelliine. The levels of DHP–DNA adducts in liver DNA of rats treated with monocrotaline were much lower than that of riddelliine-treated rats. Results from this study indicate that (i) DHP is a common reactive metabolite for retronecine-type of pyrrolizidine alkaloids, (ii) the formation of DHP-derived DNA adducts in the liver DNA of rats treated with monocrotaline suggests that monocrotaline-induced tumorigenicity is through a genotoxic mechanism. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - DNA
KW - ABDOMEN
KW - BILIARY tract
KW - DNA adducts
KW - Monocrotaline
KW - Pyrrolizidine alkaloid
N1 - Accession Number: 18127696; Wang, Yu-Ping 1 Yan, Jian 1 Beger, Richard D. 1 Fu, Peter P. 1 Chou, Ming W.; Email Address: mchou@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Aug2005, Vol. 226 Issue 1, p27; Subject Term: NUCLEIC acids; Subject Term: DNA; Subject Term: ABDOMEN; Subject Term: BILIARY tract; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Monocrotaline; Author-Supplied Keyword: Pyrrolizidine alkaloid; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.canlet.2004.11.039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18127696&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106233420
T1 - Metabolic syndrome and echocardiographic left ventricular mass in blacks: the Atherosclerosis Risk in Communities (ARIC) Study.
AU - Burchfiel CM
AU - Skelton TN
AU - Andrew ME
AU - Garrison RJ
AU - Arnett DK
AU - Jones DW
AU - Taylor HA Jr.
Y1 - 2005/08/09/2005 Aug 9
N1 - Accession Number: 106233420. Language: English. Entry Date: 20070209. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Heart, Lung, and Blood Institute contracts N01-HC-955015, N01-HC-955016, N01-HC-955018, N01-HC-955019, N01-HC-955020, N01-HC-955021, N01-HC-955022; NIH contracts N01-HC-95170, N01-HC-95171, N01-HC-95172, Jackson Heart Study, National Heart, Lung, and Blood Institute; National Center for Minority Health and Health Disparities. NLM UID: 0147763.
KW - Blacks
KW - Hypertrophy, Left Ventricular -- Epidemiology
KW - Metabolic Syndrome X -- Epidemiology
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Hypertrophy, Left Ventricular -- Ethnology
KW - Hypertrophy, Left Ventricular -- Risk Factors
KW - Hypertrophy, Left Ventricular -- Ultrasonography
KW - Male
KW - Metabolic Syndrome X -- Ethnology
KW - Metabolic Syndrome X -- Risk Factors
KW - Metabolic Syndrome X -- Ultrasonography
KW - Middle Age
KW - Mississippi
KW - Prospective Studies
KW - Risk Assessment
KW - Human
SP - 819
EP - 827
JO - Circulation
JF - Circulation
JA - CIRCULATION
VL - 112
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: The metabolic syndrome has been associated with cardiovascular disease, but few studies have examined its relationship with subclinical measures such as echocardiographic left ventricular (LV) mass. This relationship is likely to be of particular importance in blacks, in whom both the metabolic syndrome and LV hypertrophy are common. METHODS AND RESULTS: Echocardiography, performed at 1 of 4 sites in the Atherosclerosis Risk in Communities (ARIC) Study, was used to assess LV dimensions in 1572 black women and men aged 49 to 75 years in 1993-1996. Participants were categorized by number of metabolic syndrome characteristics (hypertension, dyslipidemia [low HDL cholesterol or high triglycerides], and glucose intolerance). Age-adjusted mean LV mass indexed by height (g/m) increased in a stepwise gradient with increasing number of metabolic syndrome disorders (none, any 1, any 2, all 3) in both women and men (125.1, 143.9, 153.7, 169.3 and 130.5, 148.7, 160.8, 170.2, respectively; P<0.001, tests for trend). Associations were diminished slightly by adjustment for smoking, alcohol intake, and education; additional adjustment for waist circumference resulted in some attenuation, but associations remained statistically significant. Analyses focusing on components of LV mass revealed that posterior wall and interventricular septal thickness, but not LV chamber size, were significantly and independently associated in general with the number of metabolic syndrome disorders. Consistent with these findings, relative wall thickness was also associated with number of disorders. Associations were similar across age and central adiposity. Hypertension had a strong influence on LV mass with additional contributions from dyslipidemia and glucose intolerance; strong synergistic effects of the syndrome beyond its individual components were not observed. CONCLUSIONS: In this cross-sectional population-based study of black women and men, the degree of metabolic syndrome clustering was strongly related to LV mass and its wall thickness components. These associations are consistent with a possible influence of underlying factors such as insulin resistance or other vascular processes on myocardial thickening and not on chamber size.
SN - 0009-7322
AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, M/S 4020, Morgantown, WV 26505; cburchfiel@cdc.gov
U2 - PMID: 16061739.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106233420&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - Brower, James F.
AU - Ye, Hongping
T1 - Separation and detection of the isomeric equine conjugated estrogens, equilin sulfate and Δ8,9-dehydroestrone sulfate, by liquid chromatography–electrospray-mass spectrometry using carbon-coated zirconia and porous graphitic carbon stationary phases
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2005/08/12/
VL - 1083
IS - 1/2
M3 - Article
SP - 42
EP - 51
SN - 00219673
AB - Abstract: Equilin-3-sulfate and Δ8,9-dehydroestrone-3-sulfate are two isomers found in equine conjugated estrogens that differ in structure only by the position of a double bond in the steroid B-ring. These geometric isomers were not resolved on a C18 column during the analysis of conjugated estrogen drug products by LC–MS using acetonitrile-ammonium acetate buffer as the mobile phase. While no separations of these two isomers were observed on C18 or other alkyl-bonded silica based phases using a variety of mobile phase conditions, partial separations were achieved on phenyl bonded silica phases with a resolution of 1.5 on a diphenyl phase, and baseline separations were readily achieved on two carbonaceous phases with resolutions routinely exceeding three on graphitic carbon-coated zirconia (Zr-CARB) and resolutions as high as 19 on porous graphitic carbon (Hypercarb). An examination of a selected few conjugated estrogens in the complex drug substance by LC–MS on Hypercarb is presented. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silicon compounds
KW - Carbon
KW - Estrogen
KW - Steroid hormones
KW - Carbon coated zircona
KW - Conjugated estrogens
KW - Dehydroestrone sulfate
KW - Equilin sulfate
KW - Porous graphitic carbon
KW - Zr-CARB
N1 - Accession Number: 18093314; Reepmeyer, John C.; Email Address: reepmeyerj@cder.fda.gov; Brower, James F. 1; Ye, Hongping 1; Affiliations: 1: U.S. Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA; Issue Info: Aug2005, Vol. 1083 Issue 1/2, p42; Thesaurus Term: Silicon compounds; Thesaurus Term: Carbon; Subject Term: Estrogen; Subject Term: Steroid hormones; Author-Supplied Keyword: Carbon coated zircona; Author-Supplied Keyword: Conjugated estrogens; Author-Supplied Keyword: Dehydroestrone sulfate; Author-Supplied Keyword: Equilin sulfate; Author-Supplied Keyword: Porous graphitic carbon; Author-Supplied Keyword: Zr-CARB; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chroma.2005.05.092
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18093314&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Calvert, Richard J.
AU - Kammouni, Wafa
AU - Kikawa, Keith D.
T1 - Optimization of a nonradioactive method for consistent and sensitive determination of activated K-ras protein
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2005/08/15/
VL - 343
IS - 2
M3 - Article
SP - 283
EP - 292
SN - 00032697
AB - Abstract: Accurate measurement of activity of wild-type K-ras protein is important due to its tumor suppressor action in tissues such as lung. A published method by Taylor and co-workers uses plasmid-containing Escherichia coli cells to produce a glutathione-S-transferase/raf-1 ras binding domain (GST–RBD) fusion protein attached to glutathione beads to isolate activated ras protein. We systematically optimized the method before use on lung tissues. Changing the GST–RBD protein induction temperature from the original 37 to 30°C produced a consistently greater yield of fusion protein. To improve stability of the GST–RBD beads so as to perform large-scale experiments, 0.1% NaN3 was added. NaN3-treated beads retained full affinity for at least 24 days. Sensitivity was improved by using a polyvinylidene difluoride membrane rather than nitrocellulose for immunoblotting. We also compared our GST–RBD beads with two commercial assay kits and found that our beads had both superior sensitivity and reduced variability. In summary, our modification of the GST–RBD affinity method to recover activated K-ras greatly increased the yield of fusion protein, prolonged the useful life of GST–RBD beads to at least 24 days, and enhanced detection sensitivity. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - G proteins
KW - PRESERVATION of organs, tissues, etc.
KW - CRYOBIOLOGY
KW - HISTOLOGY
KW - Activity assay
KW - K-ras
KW - Lung
N1 - Accession Number: 18160181; Calvert, Richard J. 1; Email Address: calvert@mail.ncifcrf.gov Kammouni, Wafa 2 Kikawa, Keith D. 2; Affiliation: 1: U.S. Food and Drug Administration, Office of Nutritional Products, Labeling, and Dietary Supplements, Division of Research and Applied Technology, College Park, MD 20740, USA 2: National Cancer Institute at Frederick, Laboratory of Comparative Carcinogenesis, Frederick, MD 21702, USA; Source Info: Aug2005, Vol. 343 Issue 2, p283; Subject Term: G proteins; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: CRYOBIOLOGY; Subject Term: HISTOLOGY; Author-Supplied Keyword: Activity assay; Author-Supplied Keyword: K-ras; Author-Supplied Keyword: Lung; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ab.2005.06.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18160181&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klauda
AU - J. B.
AU - Pastor
AU - R. W.
AU - Brooks
AU - B. R.
T1 - Adjacent Gauche Stabilization in Linear Alkanes: Implications for Polymer Models and Conformational Analysis.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2005/08/15/
VL - 109
IS - 33
M3 - Article
SP - 15684
EP - 15686
SN - 15206106
AB - High-level ab initio quantum mechanical calculations are used to study various gauche conformational energies of n-pentane to n-decane. The destabilizing pentane effect (adjacent gauche states of opposite sign) for alkanes is confirmed, but the energies were found to depend slightly on chain length. In contrast, introducing an adjacent gauche of the same sign requires only 0.22−0.37 kcal/mol, approximately half of the single gauche state energy. This adjacent gauche stabilization should be taken into account when formulating or analyzing rotational isomeric models, carrying out conformational analysis, and developing force fields for alkanes, lipids, and related polymers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALIPHATIC compounds
KW - STEROIDS
KW - BIOMOLECULES
KW - POLYMERS
N1 - Accession Number: 20704794; Klauda J. B. 1 Pastor R. W. 1 Brooks B. R. 1; Affiliation: 1: Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8014, and Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, Maryland 20852-1448; Source Info: Aug2005, Vol. 109 Issue 33, p15684; Subject Term: ALIPHATIC compounds; Subject Term: STEROIDS; Subject Term: BIOMOLECULES; Subject Term: POLYMERS; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luster, Michael I.
AU - Johnson, Victor J.
AU - Yucesoy, Berran
AU - Simeonova, Petia P.
T1 - Biomarkers to assess potential developmental immunotoxicity in children
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2005/08/15/
VL - 206
IS - 2
M3 - Article
SP - 229
EP - 236
SN - 0041008X
AB - Abstract: Clinical tests are readily available for assessing severe loss of immune function in children with diseases such as AIDS or primary immunodeficiency. However tests that could reliably identify subtle immune changes, as might be expected to result from exposure to developmental immunotoxic agents, are not readily available. A number of tests are described which we believe have potential applicability for epidemiological studies involving developmental immunotoxicity. Several of the tests, such as T cell receptor rearrangement excision circles (TRECs) and cytokine measurements, while highly relevant from a biological standpoint, may be precluded from use at the current time, for either technical issues or insufficient validation. Immunophenotyping and measurement of serum immunoglobulin levels, on the other hand, are well validated. Yet they may require extraordinary care in experimental design and technical performance in order to obtain data that would consistently detect subtle changes, as these tests are not generally considered highly sensitive. Quantification of the immune response to childhood vaccine, while up to the present used sparingly, may represent an excellent indicator for developmental immunotoxicity when conducted under appropriate conditions. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - Cell receptors
KW - Cellular immunity
KW - Immunotoxicology
KW - AIDS
KW - Developmental immunotoxicity
KW - Immunotoxicity
KW - Primary immunodeficiency
N1 - Accession Number: 18029581; Luster, Michael I.; Email Address: MLuster@cdc.gov; Johnson, Victor J. 1; Yucesoy, Berran 1; Simeonova, Petia P. 1; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Aug2005, Vol. 206 Issue 2, p229; Thesaurus Term: Biochemical markers; Thesaurus Term: Cell receptors; Thesaurus Term: Cellular immunity; Subject Term: Immunotoxicology; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: Developmental immunotoxicity; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Primary immunodeficiency; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.taap.2005.02.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18029581&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Slikker, William
AU - Bowyer, John F.
T1 - Biomarkers of adult and developmental neurotoxicity
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2005/08/15/
VL - 206
IS - 2
M3 - Article
SP - 255
EP - 260
SN - 0041008X
AB - Abstract: Neurotoxicity may be defined as any adverse effect on the structure or function of the central and/or peripheral nervous system by a biological, chemical, or physical agent. A multidisciplinary approach is necessary to assess adult and developmental neurotoxicity due to the complex and diverse functions of the nervous system. The overall strategy for understanding developmental neurotoxicity is based on two assumptions: (1) significant differences in the adult versus the developing nervous system susceptibility to neurotoxicity exist and they are often developmental stage dependent; (2) a multidisciplinary approach using neurobiological, including gene expression assays, neurophysiological, neuropathological, and behavioral function is necessary for a precise assessment of neurotoxicity. Application of genomic approaches to developmental studies must use the same criteria for evaluating microarray studies as those in adults including consideration of reproducibility, statistical analysis, homogenous cell populations, and confirmation with non-array methods. A study using amphetamine to induce neurotoxicity supports the following: (1) gene expression data can help define neurotoxic mechanism(s), (2) gene expression changes can be useful biomarkers of effect, and (3) the site-selective nature of gene expression in the nervous system may mandate assessment of selective cell populations. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - Neurotoxicology
KW - Cell proliferation
KW - Cytology
KW - Amphetamine
KW - amphetamine ( AMPH )
KW - Biomarkers
KW - dopamine ( DA )
KW - Gene expression
KW - insulin-like growth factor ( IGF-1 )
KW - insulin-like growth factor binding protein ( IGFBP-1 )
KW - methamphetamine ( METH )
KW - Nervous system
KW - neuropeptide Y precursor ( NPY )
KW - Neurotoxicity
KW - posteriolateral cortical amygdaloid nucleus ( PLCo )
KW - reverse transcription-polymerase chain reaction ( RT-PCR )
KW - serotonin ( 5-HT )
N1 - Accession Number: 18029584; Slikker, William; Email Address: wslikker@nctr.fda.gov; Bowyer, John F. 1; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR 72079-9502, USA; Issue Info: Aug2005, Vol. 206 Issue 2, p255; Thesaurus Term: Biochemical markers; Subject Term: Neurotoxicology; Subject Term: Cell proliferation; Subject Term: Cytology; Author-Supplied Keyword: Amphetamine; Author-Supplied Keyword: amphetamine ( AMPH ); Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: dopamine ( DA ); Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: insulin-like growth factor ( IGF-1 ); Author-Supplied Keyword: insulin-like growth factor binding protein ( IGFBP-1 ); Author-Supplied Keyword: methamphetamine ( METH ); Author-Supplied Keyword: Nervous system; Author-Supplied Keyword: neuropeptide Y precursor ( NPY ); Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: posteriolateral cortical amygdaloid nucleus ( PLCo ); Author-Supplied Keyword: reverse transcription-polymerase chain reaction ( RT-PCR ); Author-Supplied Keyword: serotonin ( 5-HT ); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.taap.2004.09.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18029584&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Golding, Hana
AU - Khurana, Surender
AU - Yarovinsky, Felix
AU - King, Lisa R.
AU - Abdoulaeva, Galina
AU - Antonsson, Liselotte
AU - Owman, Christer
AU - Platt, Emily J.
AU - Kabat, David
AU - Andersen, John F.
AU - Sher, Alan
T1 - CCR5 N-terminal Region Plays a Critical Role in HIV-1 Inhibition by Toxoplasma gondii-derived Cyclophilin-18.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/08/19/
VL - 280
IS - 33
M3 - Article
SP - 29570
EP - 29577
SN - 00219258
AB - Molecular mimicry of chemokine ligands has been described for several pathogens. Toxoplasma gondii produces a protein, cyclophilin-18 (C-18), which binds to the human immunodeficiency virus (HIV) co-receptor CCR5 and inhibits fusion and infection of T cells and macrophages by R5 viruses but not by X4 viruses. We recently identified structural determinants of C-18 required for anti-HIV activity (Yarovinsky, F., Andersen, J. F., King, L. R., Caspar, P., Aliberti, J., Golding, H., and Sher, A. (2004) J. Biol. Chem. 279, 53635–53642). Here we have elucidated the fine specificity of CCR5 residues involved in binding and HIV inhibitory potential of C-18. To delineate the regions of CCR5 involved in C-18 binding, we analyzed C-18 inhibition of cells expressing CXCR4/CCR5 chimeric receptors and CCR5 with a truncated N terminus (Δ2-19). These experiments identified a critical role for the N terminus of CCR5 in C-18 binding and anti-HIV activity. Studies with a large panel of CCR5 N-terminal peptides, including Tyr-sulfated analogues, truncated peptides, and alanine-scanning mutants, suggested that each of the 12–17 amino acids in the N terminus of CCR5 are essential for C-18 binding and inhibitory activity. Tyr sulfation did not improve C-18 reactivity. This finding is of interest because the same CCR5 N-terminal region was shown previously to play a key role in binding of HIV-1 envelope glycoproteins. The elucidation of the functional C-18-binding mechanism may help in the rational design of novel antiviral agents against HIV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXOPLASMA gondii
KW - HIV (Viruses)
KW - MIMICRY (Chemistry)
KW - PEPTIDYLPROLYL isomerase
KW - TOXOPLASMA
KW - CIS-trans-isomerases
KW - CHEMOKINES
KW - VIROLOGY
N1 - Accession Number: 18121119; Golding, Hana 1; Email Address: goldingh@eber.FDA.gov Khurana, Surender 1 Yarovinsky, Felix 2 King, Lisa R. 1 Abdoulaeva, Galina 3 Antonsson, Liselotte 4,5 Owman, Christer 4 Platt, Emily J. 5 Kabat, David 5 Andersen, John F. 6 Sher, Alan 2; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 2: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 3: Core Facility, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4: Division of Molecular Neurobiology, BMC-A12, SE-221 84 Lund, Sweden 5: Oregon Health and Sciences University, Portland, Oregon 97239 6: Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892; Source Info: 8/19/2005, Vol. 280 Issue 33, p29570; Subject Term: TOXOPLASMA gondii; Subject Term: HIV (Viruses); Subject Term: MIMICRY (Chemistry); Subject Term: PEPTIDYLPROLYL isomerase; Subject Term: TOXOPLASMA; Subject Term: CIS-trans-isomerases; Subject Term: CHEMOKINES; Subject Term: VIROLOGY; Number of Pages: 8p; Document Type: Article
L3 - 10.1074/jbc.M500236200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18121119&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106436644
T1 - Imaging and other biomarkers in early clinical studies: one step at a time or re-engineering drug development?
AU - Collins JM
Y1 - 2005/08/20/
N1 - Accession Number: 106436644. Language: English. Entry Date: 20060505. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Drug Design
SP - 5417
EP - 5419
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 23
IS - 24
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - Laboratory of Clinical Pharmacology, US Food and Drug Administration, Rockville, MD
U2 - PMID: 16027435.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106436644&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Matthew, Resa F.
AU - Wang, Min Qi
AU - Bellamy, Nikki
AU - Copeland, Evelyn
T1 - TEST OF EFFICACY OF MODEL FAMILY STRENGTHENING PROGRAMS.
JO - American Journal of Health Studies
JF - American Journal of Health Studies
Y1 - 2005/09//
VL - 20
IS - 3/4
M3 - Article
SP - 164
EP - 170
PB - American Journal of Health Studies
SN - 10900500
AB - The present study used national, multi-site data to determine the efficacy of the model programs implemented. The data (N=l,080) for the study was the Family Strengthening Initiative funded by the Center for Substance Abuse Prevention (CSAP). Data were collected using the cross-site instrument developed by CSAP and the Program Coordinating Center (PCC) staff. All study sites utilized a longitudinal, pre- and post-test design. Measures included the constructs of family resilience, family conflict, family cohesion, and family attachment. Findings from analysis of covariance (ANCOVA) showed differential effects of these model programs. For family attachment and family cohesion, the Nurturing Parenting Program appeared to be the most effective among all the model programs tested (p<.05). It is concluded that community-based organizations adopting these family-focused programs need to consider the outcome factors that are most relevant to their program. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health Studies is the property of American Journal of Health Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS -- Substance use
KW - PARENT & teenager
KW - FAMILY relations
KW - NURTURING behavior
KW - UNITED States
KW - CENTER for Substance Abuse Treatment (U.S.)
N1 - Accession Number: 23652078; Matthew, Resa F. 1 Wang, Min Qi 2 Bellamy, Nikki 3 Copeland, Evelyn 3; Affiliation: 1: McFarland Institute 2: Professor in the Department of Public and Community Health at the University of Maryland 3: Center for Substance Abuse Prevention at the Substance Abuse and Mental Health Services Administration.; Source Info: 2005, Vol. 20 Issue 3/4, p164; Subject Term: TEENAGERS -- Substance use; Subject Term: PARENT & teenager; Subject Term: FAMILY relations; Subject Term: NURTURING behavior; Subject Term: UNITED States; Company/Entity: CENTER for Substance Abuse Treatment (U.S.); Number of Pages: 7p; Document Type: Article; Full Text Word Count: 4121
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Banks, David
T1 - Pharmacists, pharmaceutical manufacturers, and conflicts of interest.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2005/09//9/1/2005
VL - 62
IS - 17
M3 - Article
SP - 1827
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Examines conflicts of interest (COI) in the relationships between pharmacists and pharmaceutical manufacturers. Therapeutic influence of pharmacists; Concept of discretionary action involving professional judgment; Issue of divided loyalties in COI; Presence of uncertainty, vulnerability and trust in medical care; Pharmaceutical manufacturer guidelines on gifts; Basis of cooperative and adversarial relationships between pharmacists and pharmaceutical makers; Federal actions on drug company relationships.
KW - PHARMACISTS
KW - CONFLICT of interests
KW - PHARMACEUTICAL industry
KW - PROFESSIONAL relationships
KW - PROFESSIONALISM
KW - GIFTS
N1 - Accession Number: 18014615; Banks, David 1; Affiliation: 1: Office of Special Health Issues, Food and Drug Administration, Rockville, MD 20857; Source Info: 9/1/2005, Vol. 62 Issue 17, p1827; Subject Term: PHARMACISTS; Subject Term: CONFLICT of interests; Subject Term: PHARMACEUTICAL industry; Subject Term: PROFESSIONAL relationships; Subject Term: PROFESSIONALISM; Subject Term: GIFTS; NAICS/Industry Codes: 453220 Gift, Novelty, and Souvenir Stores; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 6p; Document Type: Article
L3 - 10.2146/ajhp040504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18014615&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106378548
T1 - Pharmacists, pharmaceutical manufacturers, and conflicts of interest.
AU - Banks D
Y1 - 2005/09//9/1/2005
N1 - Accession Number: 106378548. Language: English. Entry Date: 20070101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Conflict of Interest
KW - Pharmaceutical Companies
KW - Pharmacists
SP - 1827
EP - 1832
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 62
IS - 17
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Office of Special Health Issues, Food and Drug Administration, Rockville, MD 20857
U2 - PMID: 16120744.
DO - 10.2146/ajhp040504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106378548&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wilson, Charlton
AU - Gilliland, Susan
AU - Cullen, Theresa
AU - Moore, Kelly
AU - Roubideaux, Yvette
AU - Valdez, Lorraine
AU - Vanderwagen, William
AU - Acton, Kelly
T1 - Diabetes Outcomes in the Indian Health System During the Era of the Special Diabetes Program for Indians and the Government Performance and Results Act.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005/09//
VL - 95
IS - 9
M3 - Article
SP - 1518
EP - 1522
PB - American Public Health Association
SN - 00900036
AB - Objectives. We reviewed changes in blood glucose, blood pressure, and cholesterol levels among American Indians and Alaska Natives between 1995 and 2001 to estimate the quality of diabetes care in the Indian Health Service (IHS) health care delivery system. Methods. We conducted a cross-sectional analysis of data from the Indian Health Service Diabetes Care and Outcomes Audit. Results. Adjusted mean Hemoglobin A1c (HbA1c) levels (7.9% vs 8.9%) and mean diastolic blood pressure levels (76 vs 79 mm Hg) were lower in 2001 than in 1995, respectively. A similar pattern was observed for mean total cholesterol (193 vs 208 mg/dL) and triglyceride (235 vs 257 mg/dL) levels in 2001 and 1995, respectively. Conclusions. We identified changes in intermediate clinical outcomes over the period from 1995 to 2001 that may reflect the global impact of increased resource allocation and improvements in processes on the quality of diabetes care, and we describe the results that may be achieved when community, health program, and congressional initiatives focus on common goals. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - INDIGENOUS peoples of the Americas -- Health
KW - BLOOD sugar
KW - BLOOD pressure measurement
KW - CHOLESTEROL
KW - MEDICAL care
N1 - Accession Number: 18105288; Wilson, Charlton 1; Email Address: charlton.wilson@ihs.gov Gilliland, Susan 2 Cullen, Theresa 3 Moore, Kelly 4 Roubideaux, Yvette 5 Valdez, Lorraine 4 Vanderwagen, William 6 Acton, Kelly 4; Affiliation: 1: Phoenix Indian Medical Center, Indian Health Service, Phoenix, Ariz. 2: Statistical Consultation and Research Center, Department of Preventive Medicine, University of Southern California, Los Angeles 3: Office of Information Technology, Indian Health Service, Tucson, Ariz. 4: Division of Diabetes Treatment and Prevention, Indian Health Service, Albuquerque, NM 5: Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson 6: Office of Clinical and Preventive Services, Indian Health Service, Rockville, Md.; Source Info: Sep2005, Vol. 95 Issue 9, p1518; Subject Term: DIABETES; Subject Term: INDIGENOUS peoples of the Americas -- Health; Subject Term: BLOOD sugar; Subject Term: BLOOD pressure measurement; Subject Term: CHOLESTEROL; Subject Term: MEDICAL care; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article; Full Text Word Count: 4230
L3 - 10.2105/AJPH.2004.053710
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18105288&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106531426
T1 - Health policy and ethics. Diabetes outcomes in the Indian Health System during the era of the Special Diabetes Program for Indians and the Government Performance and Results Act.
AU - Wilson C
AU - Gilliland S
AU - Cullen T
AU - Moore K
AU - Roubideaux Y
AU - Valdez L
AU - Vanderwagen W
AU - Acton K
Y1 - 2005/09//
N1 - Accession Number: 106531426. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Diabetes Mellitus -- Epidemiology
KW - Diabetes Mellitus -- Prevention and Control
KW - Health Resource Allocation
KW - Health Services, Indigenous -- Evaluation
KW - Outcomes (Health Care)
KW - Preventive Health Care
KW - Accountability
KW - Adult
KW - Aged
KW - Analysis of Covariance
KW - Audit
KW - Blood Glucose
KW - Cholesterol -- Blood
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Diastolic Pressure
KW - Female
KW - Health Services, Indigenous -- Legislation and Jurisprudence -- United States
KW - Health Status Indicators
KW - Hemoglobin A, Glycosylated
KW - Hypercholesterolemia -- Prevention and Control
KW - Hypertension -- Prevention and Control
KW - Male
KW - Middle Age
KW - Performance Measurement Systems
KW - Record Review
KW - Trend Studies
KW - Triglycerides -- Blood
KW - United States
KW - Human
SP - 1518
EP - 1522
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 95
IS - 9
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We reviewed changes in blood glucose, blood pressure, and cholesterol levels among American Indians and Alaska Natives between 1995 and 2001 to estimate the quality of diabetes care in the Indian Health Service (IHS) health care delivery system. METHODS: We conducted a cross-sectional analysis of data from the Indian Health Service Diabetes Care and Outcomes Audit. RESULTS: Adjusted mean Hemoglobin A1c (HbA1c) levels (7.9% vs 8.9%) and mean diastolic blood pressure levels (76 vs 79 mm Hg) were lower in 2001 than in 1995, respectively. A similar pattern was observed for mean total cholesterol (193 vs 208 mg/dL) and triglyceride (235 vs 257 mg/dL) levels in 2001 and 1995, respectively. CONCLUSIONS: We identified changes in intermediate clinical outcomes over the period from 1995 to 2001 that may reflect the global impact of increased resource allocation and improvements in processes on the quality of diabetes care, and we describe the results that may be achieved when community, health program, and congressional initiatives focus on common goals.
SN - 0090-0036
AD - Indian Health Service, Phoenix Indian Medical Center, 4212 N 16th St, Phoenix, AZ 85016; charlton.wilson@ihs.gov
U2 - PMID: 16051933.
DO - 10.2105/AJPH.2004.053710
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106531426&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106531437
T1 - Racial/ethnic disparities in potentially preventable readmissions: the case of diabetes.
AU - Jiang HJ
AU - Andrews R
AU - Stryer D
AU - Friedman B
Y1 - 2005/09//
N1 - Accession Number: 106531437. Language: English. Entry Date: 20051028. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Diabetes Mellitus -- Complications
KW - Diabetes Mellitus -- Prevention and Control
KW - Disease Management
KW - Race Factors
KW - Readmission -- Evaluation
KW - Adult
KW - After Care
KW - Age Factors
KW - Aged
KW - Blacks
KW - California
KW - Chi Square Test
KW - Cross Sectional Studies
KW - Demography
KW - Health Care Costs
KW - Health Resource Utilization
KW - Health Services Research
KW - Hispanics
KW - Hospitals
KW - Inpatients
KW - Insurance, Health
KW - International Classification of Diseases
KW - Logistic Regression
KW - Medicaid
KW - Medicare
KW - Middle Age
KW - Missouri
KW - New York
KW - P-Value
KW - Record Review
KW - Resource Databases, Health
KW - Socioeconomic Factors
KW - Tennessee
KW - Time Factors
KW - Vascular Diseases
KW - Virginia
KW - Human
SP - 1561
EP - 1567
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 95
IS - 9
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: Considerable differences in prevalence of diabetes and management of the disease exist among racial/ethnic groups. We examined the relationship between race/ethnicity and hospital readmissions for diabetes-related conditions. METHODS: Nonmaternal adult patients with Medicare, Medicaid, or private insurance coverage hospitalized for diabetes-related conditions in 5 states were identified from the 1999 State Inpatient Databases of the Healthcare Cost and Utilization Project. Racial/ethnic differences in the likelihood of readmission were estimated by logistic regression with adjustment for patient demographic, clinical, and socioeconomic characteristics and hospital attributes. RESULTS: The risk-adjusted likelihood of 180-day readmission was significantly lower for non-Hispanic Whites than for Hispanics across all 3 payers or for non-Hispanic Blacks among Medicare enrollees. Within each payer, Hispanics from low-income communities had the highest risk of readmission. Among Medicare beneficiaries, Blacks and Hispanics had higher percentages of readmission for acute complications and microvascular disease, while Whites had higher percentages of readmission for macrovascular conditions. CONCLUSIONS: Racial/ethnic disparities are more evident in 180-day than in 30-day readmission rates, and greatest among the Medicare population. Readmission diagnoses vary by race/ethnicity, with Blacks and Hispanics at higher risk for those complications more likely preventable with effective postdischarge care.
SN - 0090-0036
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; jjiang@ahrq.gov
U2 - PMID: 16118367.
DO - 10.2105/AJPH.2004.044222
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106531437&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Lee, Jang-Ik
AU - Tracy, LaRee
AU - Higgins, Karen
AU - Hernandez, Arturo
AU - Cavaille-Coll, Marc
T1 - Analysis of Exposure–Response Relationship in Everolimus–Cyclosporine Combination Regimen.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2005/09//
VL - 5
IS - 9
M3 - Letter
SP - 2328
EP - 2329
PB - Wiley-Blackwell
SN - 16006135
AB - Presents a letter to the editor in response to the article "Therapeutic Drug Monitoring for Everolimus in Heart Transplant Recipients Based on Exposure-Effect Modeling," by R. C. Starling, J. M. Hare, P. Hauptman et al in the 2004 issue.
KW - LETTERS to the editor
KW - HEART transplantation
N1 - Accession Number: 17855506; Lee, Jang-Ik 1 Tracy, LaRee 2 Higgins, Karen 2 Hernandez, Arturo 3 Cavaille-Coll, Marc 3; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration 2: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration 3: Office of Drug Evaluation IV, Center for Drug Evaluation and Research, Food and Drug Administration; Source Info: Sep2005, Vol. 5 Issue 9, p2328; Subject Term: LETTERS to the editor; Subject Term: HEART transplantation; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Letter
L3 - 10.1111/j.1600-6143.2005.00937.x
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Schubauer-Berigan, M.K.
AU - Raudabaugh, W.R.
AU - Ruder, A.M.
AU - Hein, M.J.
AU - Silver, S.R.
AU - Chen, B.
AU - Laber, P.
AU - Spaeth, S.
AU - Steenland, K.
T1 - LTAS.NET: A NIOSH Life Table Analysis System for the windows environment
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2005/09//
VL - 15
IS - 8
M3 - Abstract
SP - 656
EP - 656
SN - 10472797
AB - Purpose: Life table analysis is a fundamental tool of occupational epidemiology. A life table analysis system (LTAS) was developed by the National Institute for Occupational Safety and Health (NIOSH) in the 1980s. The current system, called PC-LTAS, is limited by its platform (MS-DOS) and by its analysis and reporting capabilities. A project was initiated to create a LTAS for the Windows operating system (LTAS.NET) that would permit the analysis of more than one exposure variable, as well as allow stratification by user-defined fixed and time-dependent covariates. Methods: A group of epidemiologists, programmers and statisticians developed system and analysis requirements. The LTAS.NET program is written in Microsoft Visual Studio.NET using a SQL Server database engine. Statistical methods include the use of (indirectly) standardized mortality ratios, (directly) standardized rate ratios, confidence intervals based on Poisson and exact methods, and the Rothman trend test for analyses of linear exposure-response associations. Comprehensive software testing strategies (including algorithms for person-time stratification and statistical calculations) were employed in the development of LTAS.NET. Results: The LTAS.NET program allows for simultaneous stratification and analysis of multiple exposure variables. Time-dependent and fixed user-defined variables, and globally defined temporal variables, can be incorporated. The import, stratification and results reporting options are highly flexible. LTAS.NET supports the use of exposure lags and consideration of active and inactive (working) person-time. Users may export stratified event and person-time data for use in Poisson regression modeling software. Conclusion: The NIOSH LTAS.NET incorporates a number of methodological improvements that should facilitate more complex life table analysis of occupational cohort data than was possible in PC-LTAS. NIOSH plans to release LTAS.NET to the public in the future. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL hygiene
KW - EPIDEMIOLOGY
KW - PUBLIC health
KW - EPIDEMIOLOGISTS
N1 - Accession Number: 18243250; Schubauer-Berigan, M.K. 1 Raudabaugh, W.R. 1 Ruder, A.M. 1 Hein, M.J. 1 Silver, S.R. 1 Chen, B. 1 Laber, P. 1 Spaeth, S. 1 Steenland, K. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH; Source Info: Sep2005, Vol. 15 Issue 8, p656; Subject Term: INDUSTRIAL hygiene; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; Subject Term: EPIDEMIOLOGISTS; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.annepidem.2005.07.027
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Petersen, A.M.
AU - Calvert, G.M.
T1 - Acute pesticide poisoning in the U.S. retail industry, 1998–2002
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2005/09//
VL - 15
IS - 8
M3 - Abstract
SP - 662
EP - 662
SN - 10472797
AB - Purpose: Workers and customers in retail establishments face a potential risk of pesticide poisoning while performing work-related activities or shopping; however little information is presently available concerning this hazard. The magnitude and incidence of acute pesticide-related poisoning among retail workers will be estimated in this analysis. Methods: Surveillance data from 1998–2002 were collected from the Sentinel Event Notification System for Occupational Risks and the California Department of Pesticide Regulation. Cases were 15–64 years old who met the case definition of acute pesticide poisoning. Incidence rates of pesticide-related illness and incidence rate ratios (IRR) comparing rates to nonagricultural, nonretail workers are used to assess risk magnitude. Results: There were 208 cases identified (198 retail employees [95%] and 10 customers [5%]). Common exposures were from disinfectants (N=99, 48%) and insecticides (N=94, 45%). Illness severity was low for 175 cases (84%), moderate for 30 (14%), high for two (1%) and one fatality was identified. There was a significant decrease in incidence rates among retail workers (8.16/million FTEs in 1998 to 4.02/million FTEs in 2002, p < 0.01). Retail employees had a significantly reduced rate of illness compared to nonagricultural, nonretail workers (IRR=0.34, 95% CI=0.29, 0.39). Occupations most commonly exposed were stock handlers/baggers (N=51, 26%), sales workers (N=44, 22%), and clerks/cashiers (N=37, 19%). Stock handlers/baggers had a significant illness risk as compared to non-agricultural, nonretail workers (IRR=1.97, 95% CI=1.49, 2.60). Retail employees at miscellaneous general stores additionally displayed a significant risk for pesticide poisoning (IRR=2.04, 95% CI=1.23, 3.39). Conclusion: Additional preventive measures are needed to decrease the risk of pesticide-related exposures in specific retail settings. Interventions include educational efforts regarding appropriate risk prevention, requirements that pesticide containers be unbreakable and tear-resistant, and greater adaptation of integrated pest management practices. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - RISK management in business
KW - POISONING
KW - AGRICULTURAL chemicals
N1 - Accession Number: 18243267; Petersen, A.M. 1 Calvert, G.M. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH; Source Info: Sep2005, Vol. 15 Issue 8, p662; Subject Term: PESTICIDES; Subject Term: RISK management in business; Subject Term: POISONING; Subject Term: AGRICULTURAL chemicals; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.annepidem.2005.07.044
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McDermott, Patrick F.
AU - Cullen, Patti
AU - Hubert, Susannah K.
AU - McDermott, Shawn D.
AU - Bartholomew, Mary
AU - Simjee, Shabbir
AU - Wagner, David D.
T1 - Changes in Antimicrobial Susceptibility of Native Enterococcus faecium in Chickens Fed Virginiamycin.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2005/09//
VL - 71
IS - 9
M3 - Article
SP - 4986
EP - 4991
SN - 00992240
AB - The extent of transfer of antimicrobial resistance from agricultural environments to humans is controversial. To assess the potential hazard posed by streptogramin use in food animals, this study evaluated the effect of virginiamycin exposure on antimicrobial resistance in Enterococcus faecium recovered from treated broilers. Four consecutive broiler feeding trials were conducted using animals raised on common litter. In the first three trials, one group of birds was fed virginiamycin continuously in feed at 20 g/ton, and a second group served as the nontreated control. In the fourth trial, antimicrobial-free feed was given to both groups. Fecal samples were cultured 1 day after chickens hatched and then at 1,3,5, and 7 weeks of age. Isolates from each time point were tested for susceptibility to a panel of different antimicrobials. Quinupristin/dalfopristin-resistant E. faecium appeared after 5 weeks of treatment in trial 1 and within 7 days of trials 2 to 4. Following removal of virginiamycin in trial 4, no resistant isolates were detected after 5 weeks. PCR failed to detect vat, vgb, or erm(B) in any of the streptogramin-resistant E. faecium isolates, whereas the msr(C) gene was detected in 97% of resistant isolates. In an experimental setting using broiler chickens, continuous virginiamycin exposure was required to maintain a stable streptogramin-resistant population of E. faecium in the animals. The bases of resistance could not be explained by known genetic determinants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG resistance
KW - ANTI-infective agents
KW - ENTEROCOCCUS
KW - CHICKENS
KW - STREPTOGRAMINS
KW - POULTRY
N1 - Accession Number: 18385076; McDermott, Patrick F. 1; Email Address: Patrick.McDermott@fda.gov Cullen, Patti 1 Hubert, Susannah K. 1 McDermott, Shawn D. 1 Bartholomew, Mary 2 Simjee, Shabbir 1 Wagner, David D. 1; Affiliation: 1: Division of Animal and Food Microbiology, Center for Veterinary Medicine, U. S. Food and Drug Administration, Laurel, Maryland. 2: Scientific Support Staff, Center for Veterinary Medicine, U S. Food and Drug Administration, Rockville, Maryland.; Source Info: Sep2005, Vol. 71 Issue 9, p4986; Subject Term: DRUG resistance; Subject Term: ANTI-infective agents; Subject Term: ENTEROCOCCUS; Subject Term: CHICKENS; Subject Term: STREPTOGRAMINS; Subject Term: POULTRY; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1128/AEM.71.9.4986-4991.2005
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Marti, Gerald E.
AU - Rawstron, Andy C.
AU - Ghia, Paolo
AU - Hillmen, Peter
AU - Houlston, Richard S.
AU - Kay, Neil
AU - Schleinitz, Thérëse Aurran
AU - Caporaso, Neil
T1 - MBL and MoBL – Response to Ziegler-Heitbrock.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2005/09//
VL - 130
IS - 5
M3 - Letter
SP - 795
EP - 796
PB - Wiley-Blackwell
SN - 00071048
AB - Presents a response to the letter to the editor concerning the diagnostic criteria for monoclonal B-cell lymphocytosis.
KW - B cells
KW - LYMPHOCYTES
KW - LETTERS to the editor
KW - monoclonal B-cell lymphocytosis
KW - nomenclature
N1 - Accession Number: 17909757; Marti, Gerald E. 1; Email Address: gemarti@hclix.nih.gov Rawstron, Andy C. 2 Ghia, Paolo 3 Hillmen, Peter 2 Houlston, Richard S. 4 Kay, Neil 5 Schleinitz, Thérëse Aurran 1,6 Caporaso, Neil 7; Affiliation: 1: Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH Bethesda, MD, USA 2: HMDS, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK 3: Universit Vita-Salute San Raffaele, Milan, Italy 4: Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK 5: Division of Hematology, Mayo Clinic, Rochester, MN, USA 6: lnstitut Paoli- Calmettes, Marseille Cedex9, France 7: Genetic Epidemiology Bra nch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA; Source Info: Sep2005, Vol. 130 Issue 5, p795; Subject Term: B cells; Subject Term: LYMPHOCYTES; Subject Term: LETTERS to the editor; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Author-Supplied Keyword: nomenclature; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1365-2141.2005.05676.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Junod, Suzanne White
T1 - Quack, Quack, Quack: The Sellers of Nostrums in Prints, Posters, Ephemera, and Books.
JO - Bulletin of the History of Medicine
JF - Bulletin of the History of Medicine
Y1 - 2005///Fall2005
VL - 79
IS - 3
M3 - Book Review
SP - 597
EP - 599
SN - 00075140
AB - Reviewed: Quack, Quack, Quack: The Sellers of Nostrums in Prints, Posters, Ephemera, and Books. Helfand, William H.
KW - QUACKS & quackery
KW - NONFICTION
KW - DRUGS
KW - MASS media
KW - ADVERTISING
KW - Helfand, William H.
KW - HELFAND, William H.
KW - QUACK, Quack, Quack: The Sellers of Nostrums in Prints, Posters, Ephemera & Books (Book)
N1 - Accession Number: 18403095; Junod, Suzanne White 1; Affiliations: 1 : U.S. Food and Drug Administration; Source Info: Fall2005, Vol. 79 Issue 3, p597; Note: Publication Information: New York: Grolier Club, 2002. 252 pp.; Historical Period: 1600 to 1999; Subject Term: QUACKS & quackery; Subject Term: NONFICTION; Subject Term: DRUGS; Subject Term: MASS media; Subject Term: ADVERTISING; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
AU - Wynne, Rebecca
T1 - Evidence for Active Drug Efflux in Fluoroquinolone Resistance in Clostridium hathewayi.
JO - Chemotherapy (0009-3157)
JF - Chemotherapy (0009-3157)
Y1 - 2005/09//
VL - 51
IS - 5
M3 - Article
SP - 256
EP - 262
SN - 00093157
AB - Background: Most fluoroquinolones have shown limited effectiveness against anaerobic bacteria. Evidence for a multidrug efflux pump, like those involved in fluoroquinolone resistance in some other bacteria, was investigated in Clostridium hathewayi. Methods:A parent strain of C.hathewayi wasisolated from human intestinal microflora on a medium with a low concentration of norfloxacin and a mutant strain was selected from it on a medium with a high concentration of norfloxacin. Fluoroquinolone sensitivity, drug accumulation, and the effects of different concentrations of fluoroquinolones on the kinetics of growth in the presence and absence of efflux pump inhibitors were measured. Results: Both strains were resistant to several fluoroquinolones and dyes. The pump inhibitor reserpine increased the sensitivity of both strains to some drugs; it affected the growth kinetics and the efflux of norfloxacin and ethidium bromide. Conclusion: The efflux of fluoroquinolone appears to be one reason for fluoroquinolone resistance inC. hathewayi. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemotherapy (0009-3157) is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM
KW - MULTIDRUG resistance
KW - ANAEROBIC bacteria
KW - NORFLOXACIN
KW - RESERPINE
KW - Anaerobic bacteria
KW - Clostridium hathewayi
KW - Efflux pump
KW - Fluoroquinolone resistance
KW - Multidrug transporter
N1 - Accession Number: 19890417; Rafii, Fatemeh 1; Email Address: frafii@nctr.fda.gov Park, Miseon 1 Wynne, Rebecca 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Ark., USA; Source Info: 2005, Vol. 51 Issue 5, p256; Subject Term: CLOSTRIDIUM; Subject Term: MULTIDRUG resistance; Subject Term: ANAEROBIC bacteria; Subject Term: NORFLOXACIN; Subject Term: RESERPINE; Author-Supplied Keyword: Anaerobic bacteria; Author-Supplied Keyword: Clostridium hathewayi; Author-Supplied Keyword: Efflux pump; Author-Supplied Keyword: Fluoroquinolone resistance; Author-Supplied Keyword: Multidrug transporter; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1159/000087253
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yan, S. Steve
AU - Pendrak, Michael L.
AU - Foley, Steven L.
AU - Powers, John H.
T1 - Campylobacter infection and Guillain–Barré syndrome: public health concerns from a microbial food safety perspective
JO - Clinical & Applied Immunology Reviews
JF - Clinical & Applied Immunology Reviews
Y1 - 2005/09//
VL - 5
IS - 5
M3 - Article
SP - 285
EP - 305
SN - 15291049
AB - Abstract: Campylobacteriosis is a leading bacterial food-borne illness in developed countries. Guillain–Barré syndrome is the most common acute flaccid paralysis due to an autoimmune disorder in nature. A considerable number of Guillain–Barré syndrome patients present with a prior history of campylobacteriosis, and Guillain–Barré syndrome is considered a sequela of infections caused specifically by Campylobacter jejuni. Because Campylobacter is normally contracted through consumption of contaminated foods including those derived from food animals, food safety measures aimed at the disruption of oral transmission will not only reduce the prevalence of campylobacteriosis but also potentially lessen the incidence of Guillain–Barré syndrome. An emerging public health concern regarding Campylobacter is the issue of microbial food safety due to increasing numbers of antimicrobial-resistant isolates. Part of the reason to address this emerging microbial food safety concern is to institute and maintain better monitoring and control programs, which require a collective effort among public health authorities. [Copyright &y& Elsevier]
AB - Copyright of Clinical & Applied Immunology Reviews is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER
KW - FOOD -- Safety measures
KW - FOOD handling
KW - PUBLIC health
KW - Antiganglioside antibodies
KW - Antimicrobial resistance
KW - Campylobacter
KW - Campylobacter fibronectin–binding protein ( CadF )
KW - Campylobacteriosis
KW - Clinical and Laboratory Standards Institute ( CLSI )
KW - Food safety
KW - ganglioside GM or GD antigen type ( GM
KW - ganglioside GM or GD antigen type ( GM, GD, or GQ )
KW - gastrointestinal ( GI )
KW - GD
KW - Guillain–Barré syndrome
KW - Guillain–Barré syndrome ( GBS )
KW - minimum inhibitory concentration or National Institutes of Health ( MIC )
KW - Monitoring program
KW - National Antimicrobial Resistance Monitoring System ( NARMS )
KW - National Committee on Clinical Laboratory Standards ( NCCLS )
KW - or GQ )
KW - Public health
N1 - Accession Number: 19200721; Yan, S. Steve 1; Email Address: syan@cvm.fda.gov Pendrak, Michael L. 2 Foley, Steven L. 3 Powers, John H. 1; Affiliation: 1: Food and Drug Administration (FDA), Rockville, MD, USA 2: National Institutes of Health, Bethesda, MD, USA 3: Department of Biology, University of Central Arkansas, Conway, AR, USA; Source Info: Sep2005, Vol. 5 Issue 5, p285; Subject Term: CAMPYLOBACTER; Subject Term: FOOD -- Safety measures; Subject Term: FOOD handling; Subject Term: PUBLIC health; Author-Supplied Keyword: Antiganglioside antibodies; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Campylobacter; Author-Supplied Keyword: Campylobacter fibronectin–binding protein ( CadF ); Author-Supplied Keyword: Campylobacteriosis; Author-Supplied Keyword: Clinical and Laboratory Standards Institute ( CLSI ); Author-Supplied Keyword: Food safety; Author-Supplied Keyword: ganglioside GM or GD antigen type ( GM; Author-Supplied Keyword: ganglioside GM or GD antigen type ( GM, GD, or GQ ); Author-Supplied Keyword: gastrointestinal ( GI ); Author-Supplied Keyword: GD; Author-Supplied Keyword: Guillain–Barré syndrome; Author-Supplied Keyword: Guillain–Barré syndrome ( GBS ); Author-Supplied Keyword: minimum inhibitory concentration or National Institutes of Health ( MIC ); Author-Supplied Keyword: Monitoring program; Author-Supplied Keyword: National Antimicrobial Resistance Monitoring System ( NARMS ); Author-Supplied Keyword: National Committee on Clinical Laboratory Standards ( NCCLS ); Author-Supplied Keyword: or GQ ); Author-Supplied Keyword: Public health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.cair.2005.08.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wyles, David L.
AU - Patel, Amita
AU - Madinger, Nancy
AU - Bessesen, Mary
AU - Krause, Philip R.
AU - Weinberg, Adriana
T1 - Development of Herpes Simplex Virus Disease in Patients Who Are Receiving Cidofovir.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2005/09//9/1/2005
VL - 41
IS - 5
M3 - Article
SP - 676
EP - 680
SN - 10584838
AB - Background. Cidofovir is a nucleotide analogue with antiviral activity against a wide range of DNA viruses, including herpes simplex virus (HSV). In vitro resistance to cidofovir has been reported with use of laboratory HSV strains; clinical failure of cidofovir therapy for HSV disease has also been reported with an isolate that was susceptible by in vitro testing. Patients and methods. Three patients with HSV disease that was unresponsive to cidofovir therapy had viral isolates obtained and stored; the isolates were analyzed for antiviral susceptibility by an antigen reduction assay (ARA). PCR cloning and automated sequencing were performed for isolates that displayed in vitro resistance. Mutations were identified by comparison with the appropriate HSV consensus sequence. Results. An HSV type 2 (HSV-2) isolate recovered from patient 2 displayed in vitro cidofovir resistance with an inhibitory concentration of 50% (IC50) of 13.06 μg/mL. HSV type 1 isolates recovered from patients 1 and 3 had elevated IC50s to cidofovir (7.32 and 8.23 μg/mL, respectively); however, these isolates did not meet the cutoff point for resistance according to the ARA. Sequencing of a cidofovir-resistant HSV-2 isolate revealed several DNA polymerase mutations that had not been previously described during in vitro resistance selection. Conclusions. To our knowledge, this is the first report of cidofovir resistance in HSV developing in vivo. The 3 sequenced clones all contained mutations truncating the poi C' end, suggesting that this region may be critical for cidofovir antiviral activity. In addition, the presence of multiple mutations suggests that the altered DNA polymerase of cidofovir-resistant virus may have introduced additional mutations into the viral genome. Introduction of the mutations identified in wild-type HSV strains is needed before the resistance phenotype can be definitively associated with any of the mutations found. Additional studies are needed to delineate the mechanisms of cidofovir resistance in HSV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antiviral agents
KW - DNA viruses
KW - Herpesvirus diseases
KW - Virus diseases -- Drug therapy
KW - Herpes simplex virus
KW - DNA polymerases
KW - Polymerase chain reaction -- Diagnostic use
N1 - Accession Number: 17849567; Wyles, David L. 1; Email Address: dwyles@ucsd.edu; Patel, Amita 2; Madinger, Nancy 3; Bessesen, Mary 4; Krause, Philip R. 2; Weinberg, Adriana 3; Affiliations: 1: Division of Infectious Diseases, University of California, San Diego.; 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.; 3: Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado.; 4: Department of Veterans Affairs Medical Center, Denver, Colorado.; Issue Info: 9/1/2005, Vol. 41 Issue 5, p676; Thesaurus Term: Antiviral agents; Thesaurus Term: DNA viruses; Subject Term: Herpesvirus diseases; Subject Term: Virus diseases -- Drug therapy; Subject Term: Herpes simplex virus; Subject Term: DNA polymerases; Subject Term: Polymerase chain reaction -- Diagnostic use; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Flynn, K.M.
AU - Delclos, K.B.
AU - Newbold, R.R.
AU - Ferguson, S.A.
T1 - Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/09//
VL - 43
IS - 9
M3 - Article
SP - 1345
EP - 1354
SN - 02786915
AB - Abstract: Methoxychlor is an insecticide with estrogen-like activity, thus exposure during development might cause sexually dimorphic behavioral alterations. To evaluate this, pregnant rats consumed diets containing 0, 10, 100 or 1000ppm methoxychlor from gestational day 7, and offspring continued on these diets until postnatal day (PND) 77. Assessments of sexually dimorphic behaviors in offspring indicated that intake of a 3.0% sodium chloride solution was significantly increased (41%) in males and females of the 1000ppm group. No treatment group differed from controls in open field nor running wheel activity, play behavior, nor 0.3% saccharin solution intake. Offspring of the 1000ppm group showed significantly decreased body weight, reaching 17% less than controls at PND 77, but not clearly related to their salt solution intake. During pregnancy, 1000ppm dams consumed 23% less food and weighed 10% less than controls, but this did not affect litter outcomes. These results indicate that in rodents, developmental and chronic exposure to dietary methoxychlor alters the sexually dimorphic behavior of salt-solution intake in young adults of both sexes. Similar behavioral alterations with other xenoestrogens, and the potential for interactions among xenoestrogens, suggest that this report may minimize the true effects of dietary methoxychlor exposure. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHOXYCHLOR
KW - INSECTICIDES
KW - SEXUAL dimorphism in animals
KW - RATS as laboratory animals
KW - SALT
KW - BODY weight
KW - ANOVA, analysis of variance
KW - DDT, dichlorodiphenyltrichloroethane
KW - Developmental
KW - EAC, endocrine active compound
KW - Endocrine disrupter
KW - GD, gestational day
KW - HPLC, high pressure liquid chromatography
KW - MET, methoxychlor
KW - Methoxychlor
KW - NCTR, National Center for Toxicological Research
KW - PND, postnatal day
KW - PPD, postparturition day
KW - PPM, parts per million
KW - Sexually dimorphic
KW - Sodium preference
KW - Xenoestrogen
N1 - Accession Number: 18094839; Flynn, K.M. 1; Email Address: flynn@adelphi.edu Delclos, K.B. 2 Newbold, R.R. 3 Ferguson, S.A. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 3: Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States; Source Info: Sep2005, Vol. 43 Issue 9, p1345; Subject Term: METHOXYCHLOR; Subject Term: INSECTICIDES; Subject Term: SEXUAL dimorphism in animals; Subject Term: RATS as laboratory animals; Subject Term: SALT; Subject Term: BODY weight; Author-Supplied Keyword: ANOVA, analysis of variance; Author-Supplied Keyword: DDT, dichlorodiphenyltrichloroethane; Author-Supplied Keyword: Developmental; Author-Supplied Keyword: EAC, endocrine active compound; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: GD, gestational day; Author-Supplied Keyword: HPLC, high pressure liquid chromatography; Author-Supplied Keyword: MET, methoxychlor; Author-Supplied Keyword: Methoxychlor; Author-Supplied Keyword: NCTR, National Center for Toxicological Research; Author-Supplied Keyword: PND, postnatal day; Author-Supplied Keyword: PPD, postparturition day; Author-Supplied Keyword: PPM, parts per million; Author-Supplied Keyword: Sexually dimorphic; Author-Supplied Keyword: Sodium preference; Author-Supplied Keyword: Xenoestrogen; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.fct.2005.03.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Jason
AU - Cain, Carol
AU - Young, Scott
AU - Chockley, Nancy
AU - Burstin, Helen
T1 - The Adoption Gap: Health Information Technology In Small Physician Practices.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/09//Sep/Oct2005
VL - 24
IS - 5
M3 - Article
SP - 1364
EP - 1366
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Health information technology (HIT) can promote higher quality, lower costs, and increased patient and clinician satisfaction. Yet small practice settings (where the vast majority of patient care is provided) have been slow to adopt HIT products and services. Successful adoption requires close attention to office workflow, or how tasks are organized and resources used to achieve outcomes. HIT improvements in the small physician office setting are achieved through strong leadership, strategic planning, process reengineering, change management, and customizing IT systems to match and support desired office workflows and health care outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFORMATION technology
KW - MEDICAL care
KW - PATIENT satisfaction
KW - MEDICAL personnel
KW - LEADERSHIP
KW - STRATEGIC planning
KW - WORKFLOW
N1 - Accession Number: 18284117; Lee, Jason 1; Email Address: jlee@nihcm.org Cain, Carol 2 Young, Scott 3 Chockley, Nancy 4 Burstin, Helen 5; Affiliation: 1: Director of Research and Policy, National Institute for Health Care Management (NIHCM) Foundation, Washington, D.C. 2: Health Information Technology Portfolio Manager, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. 3: Director for Health Information Technology, NIHCM Foundation. 4: President of NIHCM Foundation. 5: Director of Center for Primary Care, Prevention, and Clinical Partnerships, AHRQ.; Source Info: Sep/Oct2005, Vol. 24 Issue 5, p1364; Subject Term: INFORMATION technology; Subject Term: MEDICAL care; Subject Term: PATIENT satisfaction; Subject Term: MEDICAL personnel; Subject Term: LEADERSHIP; Subject Term: STRATEGIC planning; Subject Term: WORKFLOW; Number of Pages: 3p; Document Type: Article
L3 - 10.1377/hlthaff.24.5.1364
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18284117&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Woodcock, Janet
T1 - The FDA And The Safety Of Medical Products.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/09//Sep/Oct2005
VL - 24
IS - 5
M3 - Letter
SP - 1377
EP - 1377
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Presents a letter to the editor on the safety of medical products approved by the U.S. Food and Drug Administration.
KW - LETTERS to the editor
KW - MEDICAL supplies
N1 - Accession Number: 18284601; Woodcock, Janet 1; Affiliation: 1: U.S. Food and Drug Administration, Rockville, Maryland.; Source Info: Sep/Oct2005, Vol. 24 Issue 5, p1377; Subject Term: LETTERS to the editor; Subject Term: MEDICAL supplies; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 3/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bernstein, David
AU - Castranova, Vince
AU - Donaldson, Ken
AU - Fubini, Bice
AU - Hadley, John
AU - Hesterberg, Tom
AU - Kane, Agnes
AU - Lai, David
AU - McConnell, Ernest
AU - Muhle, Hartwig
AU - Oberdorster, Gunter
AU - Olin, Stephen
AU - Warheit, David
T1 - Testing of Fibrous Particles: Short-Term Assays and Strategies.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2005/09//
VL - 17
IS - 10
M3 - Article
SP - 497
EP - 537
PB - Taylor & Francis Ltd
SN - 08958378
AB - Highlights the report of the International Life Sciences Institute Risk Science Institute Working Group about the strategies and short-term assays for testing fibrous particles. Purpose of the study; Health effects of fibers; Mechanisms of fibrogenic and carcinogenic effects; Chemical and physical characteristics of fibers potentially relevant to health effects.
KW - FIBERS
KW - PLANT products
KW - LIFE sciences
KW - LEARNED institutions & societies
KW - PARTICLES (Nuclear physics)
KW - CORDAGE
N1 - Accession Number: 18001701; Bernstein, David Castranova, Vince 1 Donaldson, Ken 2 Fubini, Bice 3 Hadley, John 4 Hesterberg, Tom 5 Kane, Agnes 6 Lai, David 7 McConnell, Ernest 8 Muhle, Hartwig 9 Oberdorster, Gunter 10 Olin, Stephen 11 Warheit, David 12; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: University of Edinburgh Medical School, Edinburgh, UK 3: Interdepartmental Center "G. Scansetti" for Studies on Asbestos and other Toxic Particulates, University of Torino, Italy 4: Owens Corning Science and Technology Center, Granville, OH, USA 5: International Truck and Engine Corp., Warrenville, IL, USA 6: Brown University School of Medicine, Providence, RI, USA 7: U.S. Environmental Protection Agency, Washington, DC, USA 8: ToxPath, Inc., Raleigh, NC, USA 9: Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany 10: University of Rochester School of Environmental Medicine, Rochester, NY, USA 11: ILSI Risk Science Institute, Washington, DC, USA 12: DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE, USA; Source Info: Sep2005, Vol. 17 Issue 10, p497; Subject Term: FIBERS; Subject Term: PLANT products; Subject Term: LIFE sciences; Subject Term: LEARNED institutions & societies; Subject Term: PARTICLES (Nuclear physics); Subject Term: CORDAGE; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 314994 Rope, Cordage, Twine, Tire Cord, and Tire Fabric Mills; NAICS/Industry Codes: 314990 All other textile product mills; NAICS/Industry Codes: 813920 Professional Organizations; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 41p; Document Type: Article
L3 - 10.1080/08958370591001121
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18001701&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buchmueller, Thomas
AU - Cooper, Philip
AU - Simon, Kosali
AU - Vistnes, Jessica
T1 - The Effect of SCHIP Expansions on Health Insurance Decisions by Employers.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2005///Fall2005
VL - 42
IS - 3
M3 - Article
SP - 218
EP - 231
SN - 00469580
AB - This study uses repeated cross-sectional data from the Medical Expenditure Panel Survey-Insurance Component (MEPS-IC), a large nationally representative survey of establishments, to investigate the effect of the State Children's Health Insurance Program (SCHIP) on health insurance decisions by employers. The data span the years 1997 to 2001, the period when states were implementing SCHIP. We exploit cross-state variation in the timing of SCHIP implementation and the extent to which the program increased eligibility for public insurance. We find evidence suggesting that employers whose workers were likely to have been affected by these expansions reacted by raising employee contributions for family coverage options, and that take-up of any coverage, generally, and family coverage, specifically, dropped in these establishments. We find no evidence that employers stopped offering single or family coverage outright. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - INSURANCE
KW - MEDICAL care
KW - EMPLOYERS
KW - HEALTH care reform
KW - GROUP medical practice
KW - HEALTH insurance policies
N1 - Accession Number: 19159463; Buchmueller, Thomas 1,2; Cooper, Philip 3; Email Address: pcooper@ahrq.gov; Simon, Kosali 4,5; Vistnes, Jessica 3; Affiliations: 1: Professor, Paul Merage School of Business, University of California, Irvine; 2: Research Associate, National Bureau of Economic Research, California; 3: Senior Economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality; 4: Assistant Professor, Department of Policy Analysis and Management, Cornell University; 5: Research Fellow, National Bureau of Economic Research; Issue Info: Fall2005, Vol. 42 Issue 3, p218; Thesaurus Term: HEALTH insurance; Thesaurus Term: INSURANCE; Thesaurus Term: MEDICAL care; Thesaurus Term: EMPLOYERS; Thesaurus Term: HEALTH care reform; Thesaurus Term: GROUP medical practice; Thesaurus Term: HEALTH insurance policies; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524114 Direct Health and Medical Insurance Carriers; Number of Pages: 14p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hudson, Julie L.
AU - Selden, Thomas M.
AU - Banthin, Jessica S.
T1 - The Impact of SCHIP on Insurance Coverage of Children.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2005///Fall2005
VL - 42
IS - 3
M3 - Article
SP - 232
EP - 254
SN - 00469580
AB - In this paper we use the Medical Expenditure Panel Survey between 1996 and 2002 to investigate the impact of the State Children's Health Insurance Program (SCHIP) on insurance coverage for children. We explore a range of alternative estimation strategies, including instrumental variables and difference-in-trends models. We find that SCHIP had a significant impact in decreasing uninsurance and increasing public insurance for both children targeted by SCHIP and those eligible for Medicaid. With respect to changes in private coverage our results are less conclusive: some specifications resulted in no significant effect of SCHIP on private insurance coverage, while others showed significant decreases in private insurance. Associated estimates of SCHIP crowd-out had wide confidence intervals and were sensitive to estimation strategy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE
KW - HEALTH insurance
KW - MEDICAID
KW - MEDICAL care
KW - UNITED States
KW - MEDICAL policy
N1 - Accession Number: 19159464; Hudson, Julie L. 1; Email Address: JHudson@ahrq.gov; Selden, Thomas M. 1; Banthin, Jessica S. 2; Affiliations: 1: Economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality; 2: Director, Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality; Issue Info: Fall2005, Vol. 42 Issue 3, p232; Thesaurus Term: INSURANCE; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICAID; Thesaurus Term: MEDICAL care; Subject Term: UNITED States; Subject Term: MEDICAL policy; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 23p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106423342
T1 - The impact of SCHIP on insurance coverage of children.
AU - Hudson JL
AU - Selden TM
AU - Banthin JS
Y1 - 2005///Fall2005
N1 - Accession Number: 106423342. Language: English. Entry Date: 20060407. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Government Programs -- United States
KW - Insurance, Health -- In Infancy and Childhood
KW - Child
KW - Descriptive Statistics
KW - Models, Statistical
KW - Regression
KW - Secondary Analysis
KW - Simulations
KW - United States
KW - Human
SP - 232
EP - 254
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 42
IS - 3
PB - Sage Publications Inc.
AB - In this paper we use the Medical Expenditure Panel Survey between 1996 and 2002 to investigate the impact of the State Children's Health Insurance Program (SCHIP) on insurance coverage for children. We explore a range of alternative estimation strategies, including instrumental variables and difference-in-trends models. We find that SCHIP had a significant impact in decreasing uninsurance and increasing public insurance for both children targeted by SCHIP and those eligible for Medicaid. With respect to changes in private coverage our results are less conclusive: some specifications resulted in no significant effect of SCHIP on private insurance coverage, while others showed significant decreases in private insurance. Associated estimates of SCHIP crowd-out had wide confidence intervals and were sensitive to estimation strategy.
SN - 0046-9580
AD - Economist, Division of Modeling & Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; JHudson@ahrq.gov
U2 - PMID: 16353761.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106423342&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sing, Merrile
AU - Stevens, Beth
T1 - The Value of Experience: Differences in Knowledge Among Medicare Beneficiaries.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2005///Fall2005
VL - 42
IS - 3
M3 - Article
SP - 266
EP - 280
SN - 00469580
AB - The Medicare Advantage program gives Medicare beneficiaries the opportunity to choose from an array of insurance options instead of receiving prescribed benefits. In 2006, beneficiaries who want prescription drug benefits will need to enroll in a Medicare managed care plan or a private prescription drug plan. To examine awareness and use of Medicare information programs, and the extent to which these programs are associated with beneficiary knowledge about Medicare and managed care, we conducted a national survey of Medicare beneficiaries six to 12 months after the nationwide mailing of the Medicare & You 2000 handbook. Beneficiary information-gathering behavior and experience with Medicare managed care were more highly associated with knowledge about Medicare managed care than formal education, age, income, or membership in a managed care plan before enrolling in Medicare. Practical life experience appears to outweigh traditional factors in beneficiary knowledge of Medicare and managed care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE
KW - MANAGED care plans (Medical care)
KW - HEALTH insurance
KW - MEDICARE beneficiaries
KW - UNITED States
KW - BENEFICIARIES
N1 - Accession Number: 19159466; Sing, Merrile 1; Email Address: msing@ahrq.gov; Stevens, Beth 2; Affiliations: 1: Senior Economist, Agency for Healthcare Research and Quality; 2: Senior Researcher, Mathematica Policy Research, Inc.; Issue Info: Fall2005, Vol. 42 Issue 3, p266; Thesaurus Term: MEDICARE; Thesaurus Term: MANAGED care plans (Medical care); Thesaurus Term: HEALTH insurance; Subject Term: MEDICARE beneficiaries; Subject Term: UNITED States; Subject Term: BENEFICIARIES; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 15p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106423343
T1 - The value of experience: differences in knowledge among Medicare beneficiaries.
AU - Sing M
AU - Stevens B
Y1 - 2005///Fall2005
N1 - Accession Number: 106423343. Language: English. Entry Date: 20060407. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Grant Information: Centers for Medicare and Medicaid Services (contract no. 500-95-004717). NLM UID: 0171671.
KW - Consumer Satisfaction
KW - Health Knowledge -- In Old Age
KW - Health Services for the Aged -- Utilization
KW - Managed Care Programs
KW - Medicare -- Trends
KW - Aged
KW - Aged, 80 and Over
KW - Demography
KW - Descriptive Statistics
KW - Funding Source
KW - Questionnaires
KW - Social Class
KW - Survey Research
KW - Surveys
KW - United States
KW - Human
SP - 266
EP - 280
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 42
IS - 3
PB - Sage Publications Inc.
AB - The Medicare Advantage program gives Medicare beneficiaries the opportunity to choose from an array of insurance options instead of receiving prescribed benefits. In 2006, beneficiaries who want prescription drug benefits will need to enroll in a Medicare managed care plan or a private prescription drug plan. To examine awareness and use of Medicare information programs, and the extent to which these programs are associated with beneficiary knowledge about Medicare and managed care, we conducted a national survey of Medicare beneficiaries six to 12 months after the nationwide mailing of the Medicare & You 2000 handbook. Beneficiary information-gathering behavior and experience with Medicare managed care were more highly associated with knowledge about Medicare managed care than formal education, age, income, or membership in a managed care plan before enrolling in Medicare. Practical life experience appears to outweigh traditional factors in beneficiary knowledge of Medicare and managed care.
SN - 0046-9580
AD - Senior Economist, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; msing@ahrq.gov
U2 - PMID: 16353763.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106423343&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mayton, Alan G.
AU - Amirouche, Farid
AU - Jobes, Christopher C.
T1 - Comparison of seat designs for underground mine haulage vehicles using the absorbed power and ISO 2631-1(1985)-based ACGIH threshold limit methods.
JO - International Journal of Heavy Vehicle Systems
JF - International Journal of Heavy Vehicle Systems
Y1 - 2005/09//
VL - 12
IS - 3
M3 - Article
SP - 1
EP - 1
SN - 1744232X
AB - The article presents information on the seat designs for underground mine haulage vehicles using the absorbed power and ISO 2631-1(1985)-based ACGIH threshold limit methods. Researchers from the U.S. National Institute for Occupational Safety and Health (NIOSH) evaluated four seat designs on mine haulage vehicles, with regard to roadway-induced jarring/jolting and operator comfort. Researchers collected objective and subjective data from vehicle operators on two existing and two NIOSH seat designs. The analysis of subjective data showed that operators generally favored the NIOSH-designed seats over the existing seats.
KW - AUTOMOBILE seats
KW - VEHICLES
KW - SEATING (Furniture)
KW - UNITED States
KW - absorbed power
KW - comfort analysis
KW - mine operators
KW - mine vehicles
KW - National Institute for Occupational Safety and Health
KW - NIOSH
KW - seat designs
KW - viscoelastic foam
KW - whole body vibration
KW - NATIONAL Institute for Occupational Safety & Health
KW - INTERNATIONAL Organization for Standardization
N1 - Accession Number: 19360075; Mayton, Alan G. 1; Email Address: amayton@cdc.gov; Amirouche, Farid 2; Email Address: amirouch@uic.edu; Jobes, Christopher C. 1; Email Address: cjobes@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, PA 15236, Pittsburgh, USA.; 2: Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, 2027 Engineering Research Facility, 842 West Taylor St., IL 60607, Chicago, USA.; Issue Info: 2005, Vol. 12 Issue 3, p1; Subject Term: AUTOMOBILE seats; Subject Term: VEHICLES; Subject Term: SEATING (Furniture); Subject: UNITED States; Author-Supplied Keyword: absorbed power; Author-Supplied Keyword: comfort analysis; Author-Supplied Keyword: mine operators; Author-Supplied Keyword: mine vehicles; Author-Supplied Keyword: National Institute for Occupational Safety and Health; Author-Supplied Keyword: NIOSH; Author-Supplied Keyword: seat designs; Author-Supplied Keyword: viscoelastic foam; Author-Supplied Keyword: whole body vibration ; Company/Entity: NATIONAL Institute for Occupational Safety & Health ; Company/Entity: INTERNATIONAL Organization for Standardization; NAICS/Industry Codes: 336360 Motor Vehicle Seating and Interior Trim Manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106286566
T1 - A case of Tourette syndrome presenting with oral self-injurious behaviour.
AU - Leksell E
AU - Edvarson S
Y1 - 2005/09//
N1 - Accession Number: 106286566. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Europe; UK & Ireland. NLM UID: 9107511.
KW - Self-Injurious Behavior -- Etiology
KW - Tooth Avulsion -- Etiology
KW - Tooth Mobility -- Etiology
KW - Tourette Syndrome -- Complications
KW - Behavior Therapy
KW - Bruxism -- Complications
KW - Bruxism -- Etiology
KW - Child, Preschool
KW - Female
KW - Orthodontic Appliances
KW - Self-Injurious Behavior -- Therapy
KW - Tic -- Etiology
SP - 370
EP - 374
JO - International Journal of Paediatric Dentistry
JF - International Journal of Paediatric Dentistry
JA - INT J PAEDIATR DENT
VL - 15
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Self-injurious behaviour (SIB) is deliberate harm to the body without suicidal intent, and the condition occurs in a number of psychiatric, behavioural and developmental disorders. This case report describes a 4-year-old female with SIB who presented to a paediatric dentist after the self-extraction of teeth as a result of oral motor tics. The girl repetitively ground her teeth in a monophasic lateral motion that resulted in luxation of her maxillary right primary canine, and produced generalized oral and facial pain. The parents consulted the dentist about their child's complaint of toothache. The oral findings were unexcephonable except for a mobile primary canine, but there was a history of unusual behaviour including hyperactivity, and after multidisciplinary consultation and exclusion of other systemic diseases, the subject was diagnosed as suffering from Tourette syndrome (TS). Preventive treatment using a dental splint was provided. Noncontingent reinforcement therapy was successfully used to diminish the subject's SIB.
SN - 0960-7439
AD - Department of Paediatric Dentistry, Public Health Service, Eastman Dental Institute, Stockholm
U2 - PMID: 16129002.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106286566&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kawakami, Koji
AU - Kawakami, Mariko
AU - Liu, Qi
AU - Puri, Raj K.
T1 - Combined effects of radiation and interleukin-13 receptor-targeted cytotoxin on glioblastoma cell lines
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
Y1 - 2005/09//
VL - 63
IS - 1
M3 - Article
SP - 230
EP - 237
SN - 03603016
AB - Purpose: Interleukin-13 receptor-targeted cytotoxin (IL13-PE38) is highly cytotoxic to human glioblastoma (GBM) cells. Although this molecule is being tested in a multicenter Phase III clinical trial (PRECISE Study) in patients with recurrent disease, the activity of IL13-PE38 when combined with radiation therapy has not been investigated. Methods and Materials: Cytotoxicity of IL13-PE38 to GBM cell lines was assessed by protein synthesis inhibition and clonogenic assays, and the growth of GBM cells receiving radiation was assessed by thymidine uptake assays. Expression of IL-13 receptor α2 (IL-13Rα2) messenger ribonucleic acid (mRNA) in GBM cells exposed to radiation was assessed by quantitative reverse transcriptase/polymerase chain reaction (RT-PCR) and IL-13R density by radiolabeled IL-13 binding assays. Results: Prior irradiation of GBM cell lines followed by IL13-PE38 treatment did not enhance cytotoxicity; however, concomitant 5 Gy irradiation and IL13-PE38 treatment was highly cytotoxic to T98G, M059K, A172, and LN-229 cell lines as determined by cell viability assays. There was a statistically significant decrease in number of viable cells in IL13-PE38 and irradiated cells compared with irradiated cells alone (p < 0.05) or IL13-PE38 treated cells alone (p < 0.05). In contrast, U251, SN19, and U87MG cell lines did not show any combined effect. These results were confirmed by clonogenic assays. Although three GBM cell lines—U251, SN19, and A172—showed 2.8- to 13.9-fold upregulation of IL-13Rα2 mRNA expression at 6–24 h after exposure to 5 Gy radiation, specific binding of radiolabeled IL-13 to these cell lines did not improve. Conclusions: Our results suggest that concomitant radiation therapy and IL13-PE38 treatment may be beneficial for the treatment of patients with GBM. This strategy may be worth exploring in animal models of human glioma. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-3
KW - INTERLEUKINS
KW - MESSENGER RNA
KW - RADIOTHERAPY
KW - Cytotoxin
KW - Glioblastoma
KW - Interleukin-13 receptor
KW - Radiation
N1 - Accession Number: 18233446; Kawakami, Koji 1 Kawakami, Mariko 1 Liu, Qi 1 Puri, Raj K.; Email Address: puri@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD; Source Info: Sep2005, Vol. 63 Issue 1, p230; Subject Term: INTERLEUKIN-3; Subject Term: INTERLEUKINS; Subject Term: MESSENGER RNA; Subject Term: RADIOTHERAPY; Author-Supplied Keyword: Cytotoxin; Author-Supplied Keyword: Glioblastoma; Author-Supplied Keyword: Interleukin-13 receptor; Author-Supplied Keyword: Radiation; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijrobp.2005.05.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18233446&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106398391
T1 - AHRQ link. Using the AHRQ quality indicators to improve health care quality.
AU - Elixhauser A
AU - Pancholi M
AU - Clancy CM
Y1 - 2005/09//2005 Sep
N1 - Accession Number: 106398391. Language: English. Entry Date: 20060217. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 101238023.
KW - Clinical Indicators
KW - Patient Safety
KW - Quality of Health Care
KW - Inpatients
KW - United States Agency for Healthcare Research and Quality
SP - 533
EP - 538
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 31
IS - 9
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - In summary, the AHRQ QIs are a set of readily available programs that can be downloaded without charge from the AHRQ Web site. The methodology is completely open and accessible to all users. The QI software can be applied to hospital administrative data that is available within individual institutions or from state data organizations and hospital associations and can provide valuable insights into health care quality at extremely low cost. The QIs have been incorporated into numerous quality assessment reports, including hospital-specific reports, with the aim of improving health care quality at a reasonable cost. With enhancements currently underway, the QIs will be an even more valuable part of the toolkit to improve health care quality in the United States.
SN - 1553-7250
AD - Senior Research Scientist, Agency for Healthcare Research and Quality, Rockville, MD; aelixhau@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106383228
T1 - Methadone dosage and retention: an examination of the 60 mg/day threshold.
AU - Brady TM
AU - Salvucci S
AU - Sverdlov LS
AU - Male A
AU - Kyeyune H
AU - Sikali E
AU - DeSale S
AU - Yu P
Y1 - 2005/09//
N1 - Accession Number: 106383228. Language: English. Entry Date: 20060120. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9107051.
KW - Medication Compliance
KW - Methadone -- Administration and Dosage
KW - Substance Dependence -- Drug Therapy
KW - Adult
KW - Blacks
KW - Chi Square Test
KW - Correlation Coefficient
KW - Cox Proportional Hazards Model
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Hispanics
KW - Inferential Statistics
KW - Interviews
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Outpatients
KW - Prevalence
KW - Race Factors
KW - Regression
KW - Socioeconomic Factors
KW - Surveys
KW - Whites
KW - Human
SP - 23
EP - 47
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
JA - J ADDICT DIS
VL - 24
IS - 3
PB - Taylor & Francis Ltd
AB - A National Institutes of Health (NIH) expert panel has mentioned a daily methadone dose of at least 60 mg as a best practice in methadone maintenance. The focus of this research is to estimate the percentage of outpatient methadone clients receiving this level of methadone and examine the association between treatment retention and level of methadone dosage as recommended by the NIH expert panel. A sample of 428 methadone clients discharged from methadone treatment facilities from the Alcohol and Drug Services Study (ADSS) was used, representing 109,973 methadone clients nationally. It was estimated that more than two-thirds of methadone clients nationally were receiving below 60 mg/day. While controlling for a number of client and organizational variables, a daily methadone dose of 60 mg/day or above was found to be associated with longer retention in treatment. Exploring factors affecting the utilization of the recommended daily methadone dose remains an important issue in effective delivery of methadone treatment.
SN - 1055-0887
AD - Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 1 Choke Cherry Road, Room 7-1034, Rockville, MD 20857
U2 - PMID: 16186081.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ki Ku, Bon
AU - Maynard, Andrew D.
T1 - Comparing aerosol surface-area measurements of monodisperse ultrafine silver agglomerates by mobility analysis, transmission electron microscopy and diffusion charging
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2005/09//
VL - 36
IS - 9
M3 - Article
SP - 1108
EP - 1124
SN - 00218502
AB - Abstract: Three methods—scanning mobility particle sizer (SMPS), transmission electron microscopy (TEM), and diffusion charging (DC)—for estimating aerosol surface area were evaluated and compared. The aerosol used was monodisperse silver particles, having morphologies that range from spherical to agglomerated particles, with corresponding fractal dimensions from 1.58 to 1.94. For monodisperse silver particle agglomerates smaller than 100nm, the DC response was proportional to the mobility diameter squared, regardless of morphology. For particle sizes from 80 to 200nm, the DC response varied as the mobility diameter to the power 1.5. The projected surface area of agglomerates analyzed by TEM agreed well with that estimated from particle mobility diameters for particles smaller than 100nm. The surface area of monodisperse particles, measured by DC and SMPS, was comparable to the geometric surface area below 100nm, but in the size range of 100–200nm, the methods used underestimated the geometric surface area. SMPS, TEM, and DC-based measurements of surface area were in good agreement with one another for monodisperse aerosol particles smaller than 100nm. [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - TRANSMISSION electron microscopy
KW - ATOMIZATION
KW - ATOMIZERS
KW - Aerosol surface area
KW - Diffusion charging
KW - Silver agglomerates
N1 - Accession Number: 18235282; Ki Ku, Bon 1 Maynard, Andrew D.; Email Address: amaynard@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, Ohio 45226, USA; Source Info: Sep2005, Vol. 36 Issue 9, p1108; Subject Term: AEROSOLS (Sprays); Subject Term: TRANSMISSION electron microscopy; Subject Term: ATOMIZATION; Subject Term: ATOMIZERS; Author-Supplied Keyword: Aerosol surface area; Author-Supplied Keyword: Diffusion charging; Author-Supplied Keyword: Silver agglomerates; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.jaerosci.2004.12.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andersen, Wendy C.
AU - Roybal, Jose E.
AU - Turnipseed, Sherri B.
T1 - Liquid Chromatographic Determination of Malachite Green and Leucomalachite Green (LMG) Residues in Salmon with in situ LMG Oxidation.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1292
EP - 1298
SN - 10603271
AB - Determines malachite green and leucomalachite green residues in salmon with in situ LMG oxidation using liquid chromatography. Extraction of residues from salmon tissue with ammonium acetate buffer and acetonitrite; Solid-phase extraction; Methods and results of the research.
KW - MALACHITE
KW - SALMON
KW - CHROMATOGRAPHIC analysis
KW - LIQUID chromatography
KW - OXIDATION
KW - AMMONIUM
N1 - Accession Number: 18773977; Andersen, Wendy C. 1; Email Address: wendy.andersen@fda.hhs.gov Roybal, Jose E. 1 Turnipseed, Sherri B. 1; Affiliation: 1: U.S. Food and Drug Administration, Animal Drugs Research Center, Denver Federal Center, PO Box 25087, Denver, CO 80225-0087; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1292; Subject Term: MALACHITE; Subject Term: SALMON; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: LIQUID chromatography; Subject Term: OXIDATION; Subject Term: AMMONIUM; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turnipseed, Sherri B.
AU - Andersen, Wendy C.
AU - Roybal, José E.
T1 - Determination and Confirmation of Malachite Green and Leucomalachite Green Residues in Salmon Using Liquid Chromatography/Mass Spectrometry with No-Discharge Atmospheric Pressure Chemical Ionization.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1312
EP - 1317
SN - 10603271
AB - Determines malachite green and leucomalachite green residues in salmon using liquid chromatography/mass spectrometry with no-discharge atmospheric pressure chemical ionization. Extraction process; Generation of product-ion spectra; Use of an organic oxidizing agent.
KW - MALACHITE
KW - SALMON
KW - LIQUID chromatography
KW - MASS spectrometry
KW - OXIDIZING agents
KW - SPECTRUM analysis
N1 - Accession Number: 18773980; Turnipseed, Sherri B. 1; Email Address: sherri.turnipseed@fda.hhs.gov Andersen, Wendy C. 1 Roybal, José E. 1; Affiliation: 1: U.S. Food and Drug Administration, Animal Drugs Research Center, PO Box 25087, Denver, CO 80225-0087; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1312; Subject Term: MALACHITE; Subject Term: SALMON; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: OXIDIZING agents; Subject Term: SPECTRUM analysis; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114111 Finfish Fishing; Number of Pages: 6p; Illustrations: 2 Charts, 10 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DeVries, Jonathan W.
AU - Rader, Jeanne I.
T1 - Historical Perspective as a Guide for Identifying and Developing Applicable Methods for Dietary Fiber.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1349
EP - 1366
SN - 10603271
AB - Describes the nature and evolving definition of dietary fiber. Development of analytical methods to support food labeling regulations; Characterization and quantitation of resistance starch.
KW - FIBER in human nutrition
KW - FOOD labeling -- Law & legislation
KW - FOOD labeling
KW - STARCH
KW - FOOD law & legislation
N1 - Accession Number: 18773983; DeVries, Jonathan W. 1; Email Address: jon.devries@genmills.com Rader, Jeanne I. 2; Affiliation: 1: Medallion Laboratories, General Mills Inc., 9000 Plymouth Ave North, Minneapolis, MN 55427 2: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1349; Subject Term: FIBER in human nutrition; Subject Term: FOOD labeling -- Law & legislation; Subject Term: FOOD labeling; Subject Term: STARCH; Subject Term: FOOD law & legislation; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311221 Wet Corn Milling; Number of Pages: 18p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vega, Victor A.
T1 - Rapid Extraction of Aflatoxin from Creamy and Crunchy Peanut Butter.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1383
EP - 1386
SN - 10603271
AB - Describes the development and use of a rapid extraction technique for the isolation and subsequent liquid chromatographic determination of aflatoxins in creamy and crunchy butter. Extraction of samples of peanut butter with methanol and sodium chloride solution; Minimal solvent usage for analysis; Decrease in organic solvent consumption.
KW - AFLATOXINS
KW - PEANUT butter
KW - FOOD -- Analysis
KW - LIQUID chromatography
KW - ORGANIC solvents
N1 - Accession Number: 18773986; Vega, Victor A. 1; Email Address: vvega@ora.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 8th St, NE, Atlanta, GA 30309; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1383; Subject Term: AFLATOXINS; Subject Term: PEANUT butter; Subject Term: FOOD -- Analysis; Subject Term: LIQUID chromatography; Subject Term: ORGANIC solvents; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; Number of Pages: 4p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mercer, Gregory E.
T1 - Determination of 112 Halogenated Pesticides Using Gas Chromatography/Mass Spectrometry with Selected Ion Monitoring.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1452
EP - 1462
SN - 10603271
AB - Determines 112 halogenated pesticides using gas chromatography and mass spectrometry with selected ion monitoring. Electron impact ionization; Detection of pesticides in a variety of fruit and vegetable matrixes; Validation of the procedure using target pesticides with an acetone extraction and a solid-phase extraction cleanup.
KW - PESTICIDES
KW - HALOGENATION
KW - GAS chromatography
KW - MASS spectrometry
KW - IONIZATION (Atomic physics)
KW - SOLID-phase analysis
N1 - Accession Number: 18773996; Mercer, Gregory E. 1; Email Address: greg.mercer@fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Dr SE, Bothell, WA 98021; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1452; Subject Term: PESTICIDES; Subject Term: HALOGENATION; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: IONIZATION (Atomic physics); Subject Term: SOLID-phase analysis; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 11p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schermerhorn, Patricia G.
AU - Golden, Paul E.
AU - Krynitsky, Alexander J.
AU - Leimkuehler, William M.
T1 - Determination of 22 Triazole Compounds Including Parent Fungicides and Metabolites in Apples, Peaches, Flour, and Water by Liquid Chromatography/Tandem Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1491
EP - 1502
SN - 10603271
AB - Determines 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography and tandem mass spectrometry. Use of triazole fungicides for the multiresidue method development project; Presence of metabolites in triazole fungicides; Application of electrospray ionization in the positive-ion mode.
KW - TRIAZOLES
KW - FUNGICIDES
KW - FARM produce
KW - METABOLITES
KW - LIQUID chromatography
KW - MASS spectrometry
N1 - Accession Number: 18774000; Schermerhorn, Patricia G. 1; Email Address: schermerhorn.patricia@epa.gov Golden, Paul E. 1 Krynitsky, Alexander J. 2 Leimkuehler, William M. 3; Affiliation: 1: U.S. Environmental Protection Agency, Office of Pesticide Programs, Biological and Economic Analysis Division, Analytical Chemistry Branch, 701 Mapes Rd, Fort George G. Meade, MD 20755-5350 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-336, 5100 Paint Branch Pkwy, College Park, MD 20740-3835 3: Bayer CropScience, 17745 South Metcalf, Stilwell, KS 66085-9104; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1491; Subject Term: TRIAZOLES; Subject Term: FUNGICIDES; Subject Term: FARM produce; Subject Term: METABOLITES; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 493130 Farm Product Warehousing and Storage; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 12p; Illustrations: 4 Diagrams, 3 Charts, 20 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McClure, Foster D.
AU - Lee, Jung K.
T1 - Sample Sizes Needed for Specified Margins of Relative Error in the Estimates of the Repeatability and Reproducibility Standard Deviations.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/09//Sep/Oct2005
VL - 88
IS - 5
M3 - Article
SP - 1503
EP - 1510
SN - 10603271
AB - Discusses the development of sample size formulas to estimate the repeatability and reproducibility standard deviations. Statistical consequences associated with AOAC International required sample size to validate an analytical method; Derivation of formulas to estimate uncertainties; Definition of actual errors relative to their respective true values.
KW - MATHEMATICAL formulas
KW - ANALYTICAL chemistry
KW - STANDARD deviations
KW - ERROR
KW - ERROR analysis (Mathematics)
KW - SAMPLING (Statistics)
N1 - Accession Number: 18774001; McClure, Foster D. 1; Email Address: foster.mcclure@cfsan.fda.gov Lee, Jung K. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Sep/Oct2005, Vol. 88 Issue 5, p1503; Subject Term: MATHEMATICAL formulas; Subject Term: ANALYTICAL chemistry; Subject Term: STANDARD deviations; Subject Term: ERROR; Subject Term: ERROR analysis (Mathematics); Subject Term: SAMPLING (Statistics); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Curie, Charles G.
AU - Minkoff, Kenneth
AU - Hutchings, Gail P.
AU - Cline, Christie A.
T1 - Strategic Implementation of Systems Change for Individuals with Mental Health and Substancè Use Disorders.
JO - Journal of Dual Diagnosis
JF - Journal of Dual Diagnosis
Y1 - 2005/09//
VL - 1
IS - 4
M3 - Article
SP - 75
EP - 96
SN - 15504263
AB - The parallels or similarities between the federal approach to systems change to support services integration, and between the Comprehensive Continuous Integrated System of Care implementation process at the state or county and regional level, imply that there may be common strategic elements in the process of achieving system transformation to support widespread availability of integrated services in any system for any population. These approaches both involve fairly complex mechanisms of promoting change, built on established data-driven methodologies, such as continuous quality improvement, which have not been well-studied in large behavioral health systems attempting to implement technology transfer. This article discusses those strategies and the parallels between them. Recognition of these mechanisms may facilitate better alignment between federal and state or regional activity, provide a template for other systems seeking to create their own design process to improve services integration and, finally, suggest opportunities for design of large-scale systems research on the implementation and outcomes of integrated services development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dual Diagnosis is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - SUBSTANCE abuse
KW - ADDICTIONS
KW - MENTAL health services
KW - MENTAL health facilities
KW - PERSONALITY disorders
KW - continuous quality improvment
KW - Psychotherapeutic Intervention and Treatment
KW - SAMHSA
KW - Systems change
KW - systems integration
N1 - Accession Number: 20074935; Curie, Charles G. 1; Email Address: ccurie@samhsa.gov Minkoff, Kenneth 2; Email Address: kminkov@aol.com Hutchings, Gail P. 3; Email Address: ghutchin@samhsa.gov Cline, Christie A. 4; Email Address: cac@swcp.com; Affiliation: 1: Administrator, Substance Abuse and Mental Health Services Administration, SAMHSA. 2: Clinical Assistant Professor of Psychiatry, Harvard, and Senior Systems Consultant, ZiaLogic. 3: Chief of Staff, Substance Abuse and Mental Health Services Administration, SAMHSA. 4: President, Zialogic.; Source Info: 2005, Vol. 1 Issue 4, p75; Subject Term: MENTAL health; Subject Term: SUBSTANCE abuse; Subject Term: ADDICTIONS; Subject Term: MENTAL health services; Subject Term: MENTAL health facilities; Subject Term: PERSONALITY disorders; Author-Supplied Keyword: continuous quality improvment; Author-Supplied Keyword: Psychotherapeutic Intervention and Treatment; Author-Supplied Keyword: SAMHSA; Author-Supplied Keyword: Systems change; Author-Supplied Keyword: systems integration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 621112 Offices of Physicians, Mental Health Specialists; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 22p; Document Type: Article
L3 - 10.1300/J374v01n0410
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20074935&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106245957
T1 - Strategic implementation of systems changes for individuals with mental health and substance use disorders.
AU - Curie CG
AU - Minkoff K
AU - Hutchings GP
AU - Cline CA
Y1 - 2005/09//
N1 - Accession Number: 106245957. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101197457.
KW - Health Care Delivery, Integrated
KW - Mental Disorders -- Therapy
KW - Program Implementation
KW - Substance Use Disorders -- Therapy
KW - Collaboration
KW - Comorbidity
KW - Consumer Health Information
KW - Grants
KW - Interinstitutional Relations
KW - Leadership
KW - Organizational Objectives
KW - Professional Practice, Evidence-Based
KW - Quality Assurance
KW - Systems Analysis
SP - 75
EP - 96
JO - Journal of Dual Diagnosis
JF - Journal of Dual Diagnosis
JA - J DUAL DIAGN
VL - 1
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The parallels or similarities between the federal approach to systems change to support services integration, and between the Comprehensive Continuous Integrated System of Care implementation process at the state or county and regional level, imply that there may be common strategic elements in the process of achieving system transformation to support widespread availability of integrated services in any system for any population. These approaches both involve fairly complex mechanisms of promoting change, built on established data driven methodologies, such as continuous quality improvement, which have not been well studied in large behavioral health systems attempting to implement technology transfer. This article discusses those strategies and the parallels between them. Recognition of these mechanisms may facilitate better alignment between federal and state or regional activity, provide a template for other systems seeking to create their own design process to improve services integration, and, finally, suggest opportunities for design of large scale systems research on the implementation and outcomes of integrated services development.
SN - 1550-4263
AD - Substance Abuse and Mental Health Services Administration (SAMHSA); ccurie@samhsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shin-Hee Kim
AU - Tung-Shi Huang
AU - Seymour, Thomas A.
AU - Cheng-I Wei
AU - Kempf, Stephen C.
AU - Bridgman, C. Roger
AU - Momcilovic, Dragan
AU - Clemens, Roger A.
AU - Haejung An
T1 - Development of Immunoassay for Detection of Meat and Bone Meal in Animal Feed.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/09//
VL - 68
IS - 9
M3 - Article
SP - 1860
EP - 1865
SN - 0362028X
AB - An immunoassay system was developed for efficient detection of prohibited meat and bone meal (MBM) in animal feed. Monoclonal antibodies (MAbs) were raised against bovine smooth muscle autoclaved at 130°C for 20 min. Among the 1,500 supernatants of hybridoma cells screened, MAbs 3E1, 1G3, and 3E10 were selected and characterized in this study. The first set of MAbs produced, 3E1 and 1G3, had stronger reactivity against MBM than against smooth muscle that was heat treated at 90°C for 10 min. However, reactivity gradually increased against smooth muscle that was autoclaved at 130°C for up to 1 h. The enzyme-linked immunosorbent assay for detection of MBM in animal feed was optimized with the MAb 3E10 because of its superior performance. MAb 3E10 diluted to 100-fold was used to differentiate bovine MBM from that of other species in ingredients used for commercial animal feeds and could detect down to 0.05% MBM mixed in animal feed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Meat -- Contamination
KW - Food contamination
KW - Feeds
KW - Antigens
KW - Animal products
KW - Immunoassay
N1 - Accession Number: 18227775; Shin-Hee Kim 1; Email Address: kimshin@okstate.edu; Tung-Shi Huang 2; Seymour, Thomas A. 2; Cheng-I Wei 1; Kempf, Stephen C. 3; Bridgman, C. Roger 3; Momcilovic, Dragan 4; Clemens, Roger A. 5; Haejung An 5; Affiliations: 1: Department of Nutritional Sciences, College of Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma 74078; 2: Department of Nutrition and Food Science, Auburn University, Auburn, Alabama 36849; 3: Hybridoma Facility, Auburn University, Auburn, Alabama 36849; 4: Center of Veterinary Medicine, U.S. Food and Drug Administration, Rockville, Maryland 20855; 5: School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA; Issue Info: Sep2005, Vol. 68 Issue 9, p1860; Thesaurus Term: Meat -- Contamination; Thesaurus Term: Food contamination; Thesaurus Term: Feeds; Thesaurus Term: Antigens; Subject Term: Animal products; Subject Term: Immunoassay; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jennifer L. Brzezinski
T1 - Detection of Crustacean DNA and Species Identification Using a PCR-Restriction Fragment Length Polymorphism Method.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/09//
VL - 68
IS - 9
M3 - Article
SP - 1866
EP - 1873
SN - 0362028X
AB - The detection of potentially allergenic proteins, such as those derived from crustaceans, in food products is a major concern for the food processing industry. A PCR-restriction fragment length polymorphism (PCR-RFLP) method was designed to detect the presence of crustacean DNA in food products and to determine the species source of the DNA. This PCR assay amplifies an approximately 205-bp fragment of the 16S rRNA gene in crustacean species, including shrimp, crab, lobster, and crawfish. This reaction will not amplify DNA derived from mammals, such as cow and sheep. After amplification, the PCR product is digested with differential restriction endonucleases to determine the species source of the crustacean DNA. The specificity of this assay was demonstrated using four species of shrimp, three species of crab, and two species of lobster and crawfish. This assay is sensitive enough to detect crustacean DNA in a raw meat mixture containing «0.1% shrimp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Crustacea
KW - Food production
KW - Food industry
KW - Food
KW - Polymerase chain reaction
KW - Polymerization
N1 - Accession Number: 18227776; Jennifer L. Brzezinski 1; Email Address: jenmfer.brzczinski@fda.gov; Affiliations: 1: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, Ohio 45237, USA; Issue Info: Sep2005, Vol. 68 Issue 9, p1866; Thesaurus Term: Crustacea; Thesaurus Term: Food production; Thesaurus Term: Food industry; Thesaurus Term: Food; Subject Term: Polymerase chain reaction; Subject Term: Polymerization; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Edelson-Mammel, Sharon G.
AU - Porteous, Mary K.
AU - Buchanan, Robert L.
T1 - Survival of Enterobacter sakazakii in a Dehydrated Powdered Infant Formula.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/09//
VL - 68
IS - 9
M3 - Article
SP - 1900
EP - 1902
SN - 0362028X
AB - A quantity of dehydrated powdered infant formula was prepared to contain Enterobacter sakazakii strain 607 at approximately 106 CFU/ml when rehydrated according to the manufacturer's instructions. The survival of the microorganism in the dry formula was followed for 2 years, during which samples periodically were rehydrated and analyzed for viable E. sakazakii. During the initial 5 months of storage at room temperature, viable counts declined approximately 2.4 log cycles. During the subsequent 19 months, the concentration of viable E. sakazakii declined an additional 1.0 log cycle. These results indicate that a small percentage of E. sakazakii cells can survive for extended periods in dehydrated powdered infant formula. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gram-negative bacteria
KW - Microorganisms
KW - Microbiology
KW - Enterobacter
KW - Dried milk
KW - Dried foods
N1 - Accession Number: 18227780; Edelson-Mammel, Sharon G. 1; Porteous, Mary K. 2; Buchanan, Robert L. 1; Email Address: robert.buchanan@cfsan.fda.gov; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740; 2: Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland 20740, USA; Issue Info: Sep2005, Vol. 68 Issue 9, p1900; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Microorganisms; Thesaurus Term: Microbiology; Subject Term: Enterobacter; Subject Term: Dried milk; Subject Term: Dried foods; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dasenbrock, Catherine O.
AU - Ciolino, Laura A.
AU - Hatfield, Christine L.
AU - Jackson, David S.
T1 - The Determination of Nicotine and Sulfate in Supermarket Ground Beef Adulterated with Black Leaf 40.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2005/09//
VL - 50
IS - 5
M3 - Article
SP - 1134
EP - 1140
SN - 00221198
AB - Reports on the concurrent determination of nicotine and sulfate in ground beef which was adulterated by a supermarket employee with Black Leaf 40, a banned pesticide. Nicotine confirmed and quantitated by HPLC-UV; Sulfate determined by high performance anion exchange chromatography.
KW - MEAT -- Contamination
KW - BEEF
KW - NICOTINE
KW - SULFATES
KW - FOOD contamination
KW - HIGH performance liquid chromatography
KW - Black Leaf 40 insecticide
KW - food tampering
KW - forensic science
KW - gas chromatography mass spectrometry
KW - ground beef
KW - high performance anion exchange chromatography
KW - high performance liquid chromatography-ultraviolet detection
KW - nicotine sulfate
KW - tissue analysis
N1 - Accession Number: 18311807; Dasenbrock, Catherine O. 1 Ciolino, Laura A. 1 Hatfield, Christine L. 1,2 Jackson, David S. 1; Affiliation: 1: U. S. Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 2: U.S. Food and Drug Administration, Pacific Regional Laboratory-Northwest, Bothell, WA; Source Info: Sep2005, Vol. 50 Issue 5, p1134; Subject Term: MEAT -- Contamination; Subject Term: BEEF; Subject Term: NICOTINE; Subject Term: SULFATES; Subject Term: FOOD contamination; Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: Black Leaf 40 insecticide; Author-Supplied Keyword: food tampering; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: gas chromatography mass spectrometry; Author-Supplied Keyword: ground beef; Author-Supplied Keyword: high performance anion exchange chromatography; Author-Supplied Keyword: high performance liquid chromatography-ultraviolet detection; Author-Supplied Keyword: nicotine sulfate; Author-Supplied Keyword: tissue analysis; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 311612 Meat Processed from Carcasses; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 109848988
T1 - The Agency for Healthcare Research and Quality's patient safety network.
AU - Clancy CM
AU - Keyes MA
Y1 - 2005/09//2005 Sep
N1 - Accession Number: 109848988. Language: English. Entry Date: 20080425. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Collaboration
KW - Government Programs
KW - Patient Safety
KW - Research Priorities
KW - United States Agency for Healthcare Research and Quality
KW - Foundations
KW - Institute of Medicine (U.S.)
KW - Joint Commission
KW - Private Sector
KW - Reports
SP - 124
EP - 125
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 1
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brower, Stacey L.
AU - Roberts, Jenny R.
AU - Antonini, James M.
AU - Miller, Michael R.
T1 - Difficulty demonstrating estradiol-mediated Erk1/2 phosphorylation in MCF-7 cells
JO - Journal of Steroid Biochemistry & Molecular Biology
JF - Journal of Steroid Biochemistry & Molecular Biology
Y1 - 2005/09//
VL - 96
IS - 5
M3 - Article
SP - 375
EP - 385
SN - 09600760
AB - Abstract: While some studies report that estradiol (E2) activates extracellular-signal regulated kinase (Erk1/2) in MCF-7 breast cancer cells, others report E2 does not activate this signaling pathway. This study attempted to resolve the conflicting reports by investigating experimental variables that could impact Erk1/2 activation using a high through-put assay that quantitatively assessed Erk1/2 phosphorylation. Variables tested included: cell staging and dosing regimes with and without charcoal-stripped serum, different MCF-7 cell sublines and culture densities and several E2 formulations and solvents. Levels of phosphorylated Erk1/2 were normalized to cellular protein rather than to total Erk1/2 protein because an antibody purported to recognize total Erk1/2 preferentially reacted with non-phosphorylated Erk1/2, potentially exaggerating the apparent level of Erk1/2 activation. Dosing MCF-7 cells with E2 containing small amounts of stripped serum induced Erk1/2 phosphorylation; however, this induction was largely attributed to serum factors. E2 administered in serum-free medium did not significantly alter Erk1/2 phosphorylation under any condition tested; immunocytochemistry corroborated this conclusion. While phosphatase inhibitors generally increased Erk1/2 phosphorylation, they did not impact E2-altered Erk1/2 phosphorylation. It remains important to resolve the basis of conflicting reports regarding E2-induced Erk1/2 activation due to the potential importance of this pathway on breast cancer and other processes. [Copyright &y& Elsevier]
AB - Copyright of Journal of Steroid Biochemistry & Molecular Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICAL reactions
KW - PHOSPHORYLATION
KW - SERUM
KW - BLOOD plasma
KW - Erk/MAPK
KW - Estradiol
KW - MCF-7 cells
N1 - Accession Number: 22389153; Brower, Stacey L. 1 Roberts, Jenny R. 2 Antonini, James M. 2 Miller, Michael R. 1; Email Address: mmiller@hsc.wvu.edu; Affiliation: 1: Department of Biochemistry and Molecular Pharmacology, Mary Babb Randolph Cancer Center, P.O. Box 9142, West Virginia University Health Sciences Center, Morgantown, WV 26506-9142, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1905 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Sep2005, Vol. 96 Issue 5, p375; Subject Term: CHEMICAL reactions; Subject Term: PHOSPHORYLATION; Subject Term: SERUM; Subject Term: BLOOD plasma; Author-Supplied Keyword: Erk/MAPK; Author-Supplied Keyword: Estradiol; Author-Supplied Keyword: MCF-7 cells; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jsbmb.2005.05.006
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Improving Americans’ Health Literacy
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2005/09//
VL - 105
IS - 9
M3 - Editorial
SP - 1345
EP - 1345
SN - 00028223
N1 - Accession Number: 19647881; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Sep2005, Vol. 105 Issue 9, p1345; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2005.07.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kay, Neil E.
AU - Bone, Nancy D.
AU - Lee, Yean K.
AU - Jelinek, Diane F.
AU - Leland, Pamela
AU - Battle, Traci E.
AU - Frank, David A.
AU - Puri, Raj K.
T1 - A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells
JO - Leukemia Research
JF - Leukemia Research
Y1 - 2005/09//
VL - 29
IS - 9
M3 - Article
SP - 1009
EP - 1018
SN - 01452126
AB - Abstract: We have determined that CLL B cells consistently express type 3 membrane receptors for the Th2-derived cytokine IL-4 (IL-4R). Furthermore, when added to CLL B cells, IL-4 induces increased apoptosis resistance, increased protein synthesis in CLL B cells and rapid onset activation of STAT1, STAT5 and STAT6. Since the IL-4–IL-4R pathway is intact in CLL B cells and is related to apoptosis resistance, we considered whether we could target this pathway. A recombinant IL-4 Pseudomonas exotoxin fusion protein (IL-4PE), known to bind to IL-4R, was incubated with CLL B cells. IL-4PE (10ng/ml) cultured with CLL B cells resulted in an increase of apoptosis/death from mean levels of 46.6±7.0 of non-exposed cells to 69±8.6 (n =6). By measuring in vitro protein synthesis, two predominant patterns of sensitivity were observed. In one, CLL B cell clones (n =4) were found to be extremely sensitive to IL-4PE (IC50''s range=6–25ng/ml). In the second, low concentrations of IL-4PE induced agonist activity while increasing concentrations induced cytotoxicity in 6 of 21 patient-derived cells. These studies suggest that the IL-4R, on B-CLL cells, can serve as a unique molecular target for directing cytotoxic agents in the therapy of B-CLL. [Copyright &y& Elsevier]
AB - Copyright of Leukemia Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSEUDOMONAS
KW - PROTEIN synthesis
KW - APOPTOSIS
KW - LEUKEMIA
KW - B-CLL
KW - IL-4
KW - IL-4R
N1 - Accession Number: 18151713; Kay, Neil E. 1; Email Address: kay.neil@mayo.edu Bone, Nancy D. 1 Lee, Yean K. 1 Jelinek, Diane F. 1 Leland, Pamela 2 Battle, Traci E. 3 Frank, David A. 3 Puri, Raj K. 2; Affiliation: 1: Mayo Clinic, Stabile 628, 200 First Street SW, Rochester, MN 55905, USA 2: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA 3: Dana Farber Cancer Institute, Boston, MA, USA; Source Info: Sep2005, Vol. 29 Issue 9, p1009; Subject Term: PSEUDOMONAS; Subject Term: PROTEIN synthesis; Subject Term: APOPTOSIS; Subject Term: LEUKEMIA; Author-Supplied Keyword: B-CLL; Author-Supplied Keyword: IL-4; Author-Supplied Keyword: IL-4R; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.leukres.2004.11.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18151713&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Korst, Lisa M.
AU - Gregory, Kimberly D.
AU - Lu, Michael C.
AU - Reyes, Carolina
AU - Hobel, Calvin J.
AU - Chavez, Gilberto F.
T1 - A Framework for the Development of MaternalQuality of Care Indicators.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2005/09//
VL - 9
IS - 3
M3 - Article
SP - 317
EP - 341
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - Background: In collaboration with the California Department of Health Maternal and Child Health Branch, the authors formed a Working Group to identify potential clinical indicators that could be used to inform decision making regarding maternal health care quality. Objective: To develop potential indicators for the assessment of maternal health care quality. Materials and Methods: A Working Group was convened to review information from the published literature and expert opinion. Selection of potential indicators was guided by the following goals: 1) To identify key areas for routine aggregate monitoring; 2) To include perspectives of relevant stakeholders in maternal health care services; 3) To include measures that are comprehensive and reflect a balance between maternal and fetal interests; and 4) To develop measures that would be valid, generalizable, mutable, and feasible. Results: Ninety potential indicators were identified. Each underwent a thorough review based on: its definition, objective, and validity; its contribution to innovation; the cost and timeliness of implementation; its feasibility, acceptability, and potential effectiveness; and its compatibility with ethics, values, and social policy. This process yielded 24 final indicators from the following categories: Health Status and Access (e.g., availability of 24 h inpatient anesthesia); Preconception and Interconception Care (e.g., Pap smear use); Antenatal Care (e.g., hospitalization for uncontrolled diabetes or pyelonephritis); Labor and Delivery Care (e.g., chorioamnionitis or obstetrical hemorrhage), and Postpartum Care (e.g., rate of postpartum visits). Conclusions: These potential indicators, representative of the women's health continuum, can serve as a foundation to structure the development of consensus and methods for maternal health care quality assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Maternal & Child Health Journal is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERNAL health services
KW - MEDICAL care
KW - PREGNANCY
KW - CHILDREN -- Health
KW - PAP test
KW - MATERNAL & infant welfare
KW - health care
KW - maternal health services
KW - pregnancy
KW - quality indicators
N1 - Accession Number: 19933052; Korst, Lisa M. 1,2,3,4; Email Address: korst@usc.edu Gregory, Kimberly D. 5,6,7,8,9 Lu, Michael C. 6,9 Reyes, Carolina 4,10 Hobel, Calvin J. 5,6,7,11 Chavez, Gilberto F. 12; Affiliation: 1: Saban Research Institute of Childrens Hospital Los Angeles 2: Department of Pediatrics, Keck School of Medicine, University of Southern California 3: Division of Research on Children, Youth, and Families, Keck School of Medicine, University of Southern California 4: Department of Obstetrics & Gynecology, Keck School of Medicine, University of Southern California 5: Burns and Allen Research Institute of Cedars-Sinai Medical Center 6: Department of Obstetrics & Gynecology, David Geffen School of Medicine, University of Southern California 7: Division of Maternal Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles 8: Division of Women’s Health Services Research and Policy, David Geffen School of Medicine, University of California, Los Angeles 9: Department of Community Health Services, School of Public Health, University of California, Los Angeles 10: Agency for Healthcare Research and Quality Rockville, MD 11: Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles 12: California Department of Health Services; Source Info: Sep2005, Vol. 9 Issue 3, p317; Subject Term: MATERNAL health services; Subject Term: MEDICAL care; Subject Term: PREGNANCY; Subject Term: CHILDREN -- Health; Subject Term: PAP test; Subject Term: MATERNAL & infant welfare; Author-Supplied Keyword: health care; Author-Supplied Keyword: maternal health services; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: quality indicators; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 25p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1007/s10995-005-0001-y
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Rasooly, Avraham
T1 - Biosensor technologies
JO - Methods
JF - Methods
Y1 - 2005/09//
VL - 37
IS - 1
M3 - Editorial
SP - 1
EP - 3
SN - 10462023
N1 - Accession Number: 18778859; Rasooly, Avraham 1; Email Address: rasoolya@mail.nih.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biological Sciences, The National Cancer Institutes, Cancer Diagnosis Program, 6130 Executive Blvd., Rockville, MD 20852, USA; Source Info: Sep2005, Vol. 37 Issue 1, p1; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.ymeth.2005.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18778859&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lan Hu
AU - Raybourne, Richard B.
AU - Kopecko, Dennis J.
T1 - Ca2+ release from host intracellular stores and related signal transduction during Campylobacter jejuni 81-176 internalization into human intestinal cells.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2005/09//
VL - 151
IS - 9
M3 - Article
SP - 3097
EP - 3105
SN - 13500872
AB - The article reports on the role of Campylobacter jejuni in human diarrheal disease. The ability of C. jejuni to invade the host intestinal epithelium is an important determinant of virulence. This pathogen displays the mechanism commonly used by pathogenic invasive microorganisms. The effects of calcium availability on invasion of human intestinal epithelial cells by C. jejuni strain 81-176 is analyzed.
KW - Campylobacter jejuni
KW - Pathogenic microorganisms
KW - Virulence (Microbiology)
KW - Gram-negative bacterial diseases
KW - Campylobacter infections
KW - Diarrhea
KW - Calcium in the body
KW - Gastrointestinal diseases
N1 - Accession Number: 19760363; Lan Hu 1; Raybourne, Richard B. 2; Kopecko, Dennis J. 1; Email Address: kopecko@cber.fda.gov; Affiliations: 1: Laboratory of Enteric and Sexually Transmitted Diseases, FDA-Center for Biologics Evaluation and Research, 29 Lincoln Drive, Bldg 29/420 HFM440, Bethesda, MD 20892, USA; 2: Virulence Assessment, FDA-Center, Food Safety and Nutrition, Laurel, MD 20708, USA; Issue Info: Sep2005, Vol. 151 Issue 9, p3097; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Gram-negative bacterial diseases; Thesaurus Term: Campylobacter infections; Subject Term: Diarrhea; Subject Term: Calcium in the body; Subject Term: Gastrointestinal diseases; Number of Pages: 9p; Illustrations: 2 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1099/mic.0.27866-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19760363&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Young Jun Im
AU - Raychaudhuri, Sumana
AU - Prinz, William A.
AU - Hurley, James H.
T1 - Structural mechanism for sterol sensing and transport by OSBP-related proteins.
JO - Nature
JF - Nature
Y1 - 2005/09//9/1/2005
VL - 437
IS - 7055
M3 - Letter
SP - 154
EP - 158
PB - Nature Publishing Group
SN - 00280836
AB - The oxysterol-binding-protein (OSBP)-related proteins (ORPs) are conserved from yeast to humans, and are implicated in the regulation of sterol homeostasis and in signal transduction pathways. Here we report the structure of the full-length yeast ORP Osh4 (also known as Kes1) at 1.5–1.9 Å resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxycholesterol. We find that a single sterol molecule binds within a hydrophobic tunnel in a manner consistent with a transport function for ORPs. The entrance is blocked by a flexible amino-terminal lid and surrounded by basic residues that are critical for Osh4 function. The structure of the open state of a lid-truncated form of Osh4 was determined at 2.5 Å resolution. Structural analysis and limited proteolysis show that sterol binding closes the lid and stabilizes a conformation favouring transport across aqueous barriers and signal transmission. The structure of Osh4 in the absence of ligand exposes potential phospholipid-binding sites that are positioned for membrane docking and sterol exchange. On the basis of these observations, we propose a model in which sterol and membrane binding promote reciprocal conformational changes that facilitate a sterol transfer and signalling cycle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LETTERS to the editor
KW - CARRIER proteins
KW - OXYSTEROLS
KW - PROTEINS
KW - STEROLS
KW - BIOLOGICAL control systems
KW - BIOCHEMISTRY
KW - YEAST
KW - HUMAN beings
KW - PHOSPHOLIPIDS
N1 - Accession Number: 18125024; Young Jun Im 1,2 Raychaudhuri, Sumana 3 Prinz, William A. 3 Hurley, James H. 1; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA 2: Department of Life Science, Gwangju Institute of Science and Technology, Oryongdong 1, Bukgu, Gwangju City 500-712, South Korea 3: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA; Source Info: 9/1/2005, Vol. 437 Issue 7055, p154; Subject Term: LETTERS to the editor; Subject Term: CARRIER proteins; Subject Term: OXYSTEROLS; Subject Term: PROTEINS; Subject Term: STEROLS; Subject Term: BIOLOGICAL control systems; Subject Term: BIOCHEMISTRY; Subject Term: YEAST; Subject Term: HUMAN beings; Subject Term: PHOSPHOLIPIDS; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 5p; Document Type: Letter
L3 - 10.1038/nature03923
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shin, E.-J.
AU - Suh, S.K.
AU - Lim, Y.K.
AU - Jhoo, W.-K.
AU - Hjelle, O.P.
AU - Ottersen, O.P.
AU - Shin, C.Y.
AU - Ko, K.H.
AU - Kim, W.-K.
AU - Kim, D.S.
AU - Chun, W.
AU - Ali, S.
AU - Kim, H.-C.
T1 - Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis
JO - Neuroscience
JF - Neuroscience
Y1 - 2005/09//
VL - 133
IS - 3
M3 - Article
SP - 715
EP - 727
SN - 03064522
AB - Abstract: The specific role of endogenous glutathione in response to neuronal degeneration induced by trimethyltin (TMT) in the hippocampus was examined in rats. A single injection of TMT (8mg/kg, i.p.) produced a rapid increase in the formation of hydroxyl radical and in the levels of malondialdehyde (MDA) and protein carbonyl. TMT-induced seizure activity significantly increased after this initial oxidative stress, and remained elevated for up to 2 weeks post-TMT. Although a significant loss of hippocampal Cornus Ammonis CA1, CA3 and CA4 neurons was observed at 3 weeks post-TMT, the elevation in the level of hydroxyl radicals, MDA, and protein carbonyl had returned to near-control levels at that time. In contrast, the ratio of reduced to oxidized glutathione remained significantly decreased at 3 weeks post-TMT, and the glutathione-like immunoreactivity of the pyramidal neurons was decreased. However glutathione-positive glia-like cells proliferated mainly in the CA1, CA3, and CA4 sectors and were intensely immunoreactive. Double labeling demonstrated the co-localization of glutathione-immunoreactive glia-like cells and reactive astrocytes, as indicated by immunostaining for glial fibrillary acidic protein. This suggests that astroglial cells were mobilized to synthesize glutathione in response to the TMT insult. The TMT-induced changes in glutathione-like immunoreactivity appear to be concurrent with changes in the expression levels of glutathione peroxidase and glutathione reductase. Ascorbate treatment significantly attenuated TMT-induced seizures, as well as the initial oxidative stress, impaired glutathione homeostasis, and neuronal degeneration in a dose-dependent manner. These results suggest that ascorbate is an effective neuroprotectant against TMT. The initial oxidative burden induced by TMT may be a causal factor in the generation of seizures, prolonged disturbance of endogenous glutathione homeostasis, and consequent neuronal degeneration. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOLOGICAL control systems
KW - LIMBIC system
KW - CEREBRAL cortex
KW - NERVOUS system
KW - 2
KW - 2,3-dihydroxybenzoic acid ( 2,3-DHBA )
KW - 2,4-dinitrophenylhydrazine ( DNPH )
KW - 2,5-dihydroxybenzoic acid ( 2,5-DHBA )
KW - 3-DHBA )
KW - 3-dihydroxybenzoic acid ( 2
KW - 4-dinitrophenylhydrazine ( DNPH )
KW - 5-DHBA )
KW - 5-dihydroxybenzoic acid ( 2
KW - analysis of variance ( ANOVA )
KW - ascorbate
KW - brain-derived neurotropic factor ( BDNF )
KW - Cornus Ammonis ( CA )
KW - Duncan’s new multiple range ( DMR )
KW - glial fibrillary acidic protein ( GFAP )
KW - glutathione homeostasis
KW - glutathione peroxidase ( GPX )
KW - glutathione reductase ( GRX )
KW - half-life ( t1/2 )
KW - hippocampus
KW - kainate ( KA )
KW - malondialdehyde ( MDA )
KW - N-methyl-d-aspartate ( NMDA )
KW - National Institutes of Health ( NIH )
KW - neuronal degeneration
KW - oxidative burdens
KW - oxidized glutathione ( GSSG )
KW - phosphate-buffered saline ( PBS )
KW - phosphate-buffered saline containing 0.01% Triton X-100 ( PBS-T )
KW - reactive oxygen species ( ROS )
KW - reduced glutathione ( GSH )
KW - Sprague-Dawley ( S-D )
KW - stratum pyramidale ( SP )
KW - stratum radiatum ( SR )
KW - triethyltin ( TET )
KW - trimethyltin
KW - trimethyltin ( TMT )
N1 - Accession Number: 17924397; Shin, E.-J. 1 Suh, S.K. 2 Lim, Y.K. 1 Jhoo, W.-K. 1 Hjelle, O.P. 3 Ottersen, O.P. 3 Shin, C.Y. 4 Ko, K.H. 4 Kim, W.-K. 5 Kim, D.S. 2 Chun, W. 6 Ali, S. 7 Kim, H.-C. 1; Email Address: kimhc@kangwon.ac.kr; Affiliation: 1: Neurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea 2: Korea Food and Drug Administration, Seoul 122-074, South Korea 3: Center for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, 0317 Oslo, Norway 4: College of Pharmacy, Seoul National University, Seoul 151-742, South Korea 5: Ewha Institute of Neuroscience, Ewha University Medical School, Seoul 110-783, South Korea 6: Department of Pharmacology, College of Medicine, Kangwon National University, Chunchon 200-701, South Korea 7: Neurochemistry Laboratory, Division of Neurotoxicology, NCTR/FDA, Jefferson, AR 72079, USA; Source Info: Sep2005, Vol. 133 Issue 3, p715; Subject Term: BIOLOGICAL control systems; Subject Term: LIMBIC system; Subject Term: CEREBRAL cortex; Subject Term: NERVOUS system; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2,3-dihydroxybenzoic acid ( 2,3-DHBA ); Author-Supplied Keyword: 2,4-dinitrophenylhydrazine ( DNPH ); Author-Supplied Keyword: 2,5-dihydroxybenzoic acid ( 2,5-DHBA ); Author-Supplied Keyword: 3-DHBA ); Author-Supplied Keyword: 3-dihydroxybenzoic acid ( 2; Author-Supplied Keyword: 4-dinitrophenylhydrazine ( DNPH ); Author-Supplied Keyword: 5-DHBA ); Author-Supplied Keyword: 5-dihydroxybenzoic acid ( 2; Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: ascorbate; Author-Supplied Keyword: brain-derived neurotropic factor ( BDNF ); Author-Supplied Keyword: Cornus Ammonis ( CA ); Author-Supplied Keyword: Duncan’s new multiple range ( DMR ); Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: glutathione homeostasis; Author-Supplied Keyword: glutathione peroxidase ( GPX ); Author-Supplied Keyword: glutathione reductase ( GRX ); Author-Supplied Keyword: half-life ( t1/2 ); Author-Supplied Keyword: hippocampus; Author-Supplied Keyword: kainate ( KA ); Author-Supplied Keyword: malondialdehyde ( MDA ); Author-Supplied Keyword: N-methyl-d-aspartate ( NMDA ); Author-Supplied Keyword: National Institutes of Health ( NIH ); Author-Supplied Keyword: neuronal degeneration; Author-Supplied Keyword: oxidative burdens; Author-Supplied Keyword: oxidized glutathione ( GSSG ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: phosphate-buffered saline containing 0.01% Triton X-100 ( PBS-T ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: reduced glutathione ( GSH ); Author-Supplied Keyword: Sprague-Dawley ( S-D ); Author-Supplied Keyword: stratum pyramidale ( SP ); Author-Supplied Keyword: stratum radiatum ( SR ); Author-Supplied Keyword: triethyltin ( TET ); Author-Supplied Keyword: trimethyltin; Author-Supplied Keyword: trimethyltin ( TMT ); Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.neuroscience.2005.02.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106547980
T1 - Pandemic influenza: how worried should we be?
AU - Jones JD
Y1 - 2005///2005 Fall-Winter Spotlight on Research, Issue 22: Fall 2005
N1 - Accession Number: 106547980. Language: English. Entry Date: 20051202. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2005 Fall-Winter Spotlight on Research, Issue 22: Fall 2005. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 101093000.
KW - Disaster Planning
KW - Disease Outbreaks
KW - Influenza -- Prevention and Control
KW - Disease Management
KW - Disease Transmission, Horizontal
KW - Influenza -- History
KW - Organizational Development
KW - Public Health -- History
KW - Zoonoses
SP - 17
EP - 17
JO - Northwest Public Health
JF - Northwest Public Health
JA - NORTHWEST PUBLIC HEALTH
VL - 22
IS - 2
CY - Seattle, Washington
PB - University of Washington, School of Public Health & Community Medicine
SN - 1536-9102
AD - Physician Epidemiologist, Portland Area Office, Indian Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Eakley, Melissa
AU - Gallauresi, Beverly Albrecht
AU - Morrison, Audrey
T1 - Luer-lock misconnects can be deadly.
JO - Nursing
JF - Nursing
Y1 - 2005/09//
VL - 35
IS - 9
M3 - Article
SP - 73
EP - 73
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article focuses on the errorneous use of devices like leur fittings, connectors, and locks in clinical medicine. The U.S. Food and Drug Administration has received reports of enteral feeding tubes mistakenly connected to intravenous (I.V.) lines and tracheal tube pilot balloons. Other reported errors involving luer connections include connecting oxygen tubing to endotracheal tube pilot balloons, noninvasive blood pressure cuffs connected to I.V. lines, and drugs intended for I.V. administration given intrathecally.
KW - MEDICAL equipment
KW - MEDICAL errors
KW - CLINICAL medicine
KW - INTRATRACHEAL anesthesia
KW - BLOOD pressure
KW - INTRAVENOUS therapy
N1 - Accession Number: 18035884; Eakley, Melissa 1 Gallauresi, Beverly Albrecht 1 Morrison, Audrey 1; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health, FDA in Rockville, Md.; Source Info: Sep2005, Vol. 35 Issue 9, p73; Subject Term: MEDICAL equipment; Subject Term: MEDICAL errors; Subject Term: CLINICAL medicine; Subject Term: INTRATRACHEAL anesthesia; Subject Term: BLOOD pressure; Subject Term: INTRAVENOUS therapy; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106524597
T1 - Device safety. Luer-lock misconnects can be deadly.
AU - Eakle M
AU - Gallauresi BA
AU - Morrison A
Y1 - 2005/09//
N1 - Accession Number: 106524597. Language: English. Entry Date: 20051014. Revision Date: 20150820. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety
KW - Intravenous Therapy Equipment and Supplies -- Adverse Effects
KW - Treatment Errors -- Prevention and Control
KW - Catheters, Vascular
KW - Endotracheal Tubes
KW - Feeding Tubes
KW - Female
KW - Male
SP - 73
EP - 73
JO - Nursing
JF - Nursing
JA - NURSING
VL - 35
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Center for Devices and Radiological Health, FDA, Rockville, MD
U2 - PMID: 16148805.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Aidoo, Anane
AU - Bishop, Michelle E.
AU - Shelton, Sharon D.
AU - Lyn-Cook, Lascelles E.
AU - Tao Chen
AU - Manjanatha, Mugimane G.
T1 - Effects of Daidzein, Genistein, and 17β-Estradiol on 7,12-Dimethylbenz[a]anthracene-Induced Mutagenicity and Uterine Dysplasia in Ovariectomized Rats.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2005/09//
VL - 53
IS - 1
M3 - Article
SP - 82
EP - 90
PB - Taylor & Francis Ltd
SN - 01635581
AB - Abstract: Phytoestrogens, primarily isoflavones daidzein (DZ) and genistein (GE), are increasingly used by postmenopausal women as an alternative to hormone replacement therapy due to reports that estrogen therapy increases the risk of breast and endometrial cancers. These compounds, as estrogen receptor agonists, may influence chemical carcinogenesis in estrogen-responsive tissues such as the uterus. We utilized ovariectomized (OVX) rats to model menopause and assessed the effects of dietary DZ, GE, or 17β-estradiol (E2) on carcinogen-induced mutagenesis and carcinogenesis in the rat uterus. Big Blue® transgenic rats (derived from Fischer 344 strain) were exposed to 7,12-dimethylbenz[a]anthracene (DMBA) in the presence or absence of the supplements. At 16- or 20-wk sacrifice, the uteri were removed and processed to determine mutant frequencies (MFs) and immunohistochemical or histopathological parameters, respectively. In rats treated with DMBA alone, a significant increase in lacI MFs (P < 0.01) in both OVX and intact (INT) rats was observed. The DMBA-induced MFs were not significantly altered by dietary DZ, GE, or E2 in both OVX and INT rats. Although dysplasia was not induced in the uterus of OVX and INT rats treated with DMBA alone, it was detected in 55% of OVX rats fed E2 alone and in 100% of OVX rats fed E2 along with DMBA exposure. Cell proliferation also was significantly higher in OVX rats fed E2 and treated with DMBA. In rats fed the isoflavones and treated with DMBA, the incidence of dysplasia was either reduced or virtually absent in both OVX and INT groups. These results indicate that a high incidence of dysplasia was associated with E2 feeding with or without DMBA treatment in the OVX rats, whereas the incidence was low in rats fed DZ or GE and treated with DMBA, suggesting a weak estrogen receptor agonist of DZ or GE in the rat uterus. The absence of dysplasia in OVX rats exposed to DMBA alone also suggests, in part, a promotional mechanism via estrogen- or isoflavone-driven cell proliferation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTRADIOL
KW - MUTAGENICITY testing
KW - DYSPLASIA
KW - RATS as laboratory animals
KW - ESTROGEN
KW - MENOPAUSE
KW - ISOFLAVONES
KW - CELL proliferation
N1 - Accession Number: 19120764; Aidoo, Anane 1 Bishop, Michelle E. 1 Shelton, Sharon D. 1 Lyn-Cook, Lascelles E. 1 Tao Chen 1 Manjanatha, Mugimane G. 1; Affiliation: 1: FDA Jefferson Laboratories, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, Arkansas 72079; Source Info: 2005, Vol. 53 Issue 1, p82; Subject Term: ESTRADIOL; Subject Term: MUTAGENICITY testing; Subject Term: DYSPLASIA; Subject Term: RATS as laboratory animals; Subject Term: ESTROGEN; Subject Term: MENOPAUSE; Subject Term: ISOFLAVONES; Subject Term: CELL proliferation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1207/s15327914nc5301_10
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19120764&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106322566
T1 - Effects of daidzein, genistein, and 17beta-estradiol on 7,12-dimethylbenz[a]anthracene-induced mutagenicity and uterine dysplasia in ovariectomized rats.
AU - Aidoo A
AU - Bishop ME
AU - Shelton SD
AU - Lyn-Cook LE
AU - Chen T
AU - Manjanatha MG
Y1 - 2005/09//
N1 - Accession Number: 106322566. Language: English. Entry Date: 20060825. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Funded in part by the FDA Office of Women's Health, Washington, DC. NLM UID: 7905040.
KW - Estradiol -- Pharmacodynamics
KW - Isoflavones -- Pharmacodynamics
KW - Mutation -- Evaluation
KW - Proteins -- Antagonists and Inhibitors
KW - Uterus -- Pathology
KW - Analysis of Variance
KW - Animals
KW - Cell Physiology
KW - Chemoprevention
KW - Drug Interactions
KW - Genetic Techniques
KW - Oophorectomy
KW - Post Hoc Analysis
KW - Rats
KW - T-Tests
KW - Toxicity Tests
KW - Funding Source
KW - Animal Studies
SP - 82
EP - 90
JO - Nutrition & Cancer
JF - Nutrition & Cancer
JA - NUTR CANCER
VL - 53
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Phytoestrogens, primarily isoflavones daidzein (DZ) and genistein (GE), are increasingly used by postmenopausal women as an alternative to hormone replacement therapy due to reports that estrogen therapy increases the risk of breast and endometrial cancers. These compounds, as estrogen receptor agonists, may influence chemical carcinogenesis in estrogen-responsive tissues such as the uterus. We utilized ovariectomized (OVX) rats to model menopause and assessed the effects of dietary DZ, GE, or 17beta-estradiol (E2) on carcinogen-induced mutagenesis and carcinogenesis in the rat uterus. Big Blue transgenic rats (derived from Fischer 344 strain) were exposed to 7,12-dimethylbenz[a]anthracene (DMBA) in the presence or absence of the supplements. At 16- or 20-wk sacrifice, the uteri were removed and processed to determine mutant frequencies (MFs) and immunohistochemical or histopathological parameters, respectively. In rats treated with DMBA alone, a significant increase in lacI MFs (P < 0.01) in both OVX and intact (INT) rats was observed. The DMBA-induced MFs were not significantly altered by dietary DZ, GE, or E2 in both OVX and INT rats. Although dysplasia was not induced in the uterus of OVX and INT rats treated with DMBA alone, it was detected in 55% of OVX rats fed E2 alone and in 100% of OVX rats fed E2 along with DMBA exposure. Cell proliferation also was significantly higher in OVX rats fed E2 and treated with DMBA. In rats fed the isoflavones and treated with DMBA, the incidence of dysplasia was either reduced or virtually absent in both OVX and INT groups. These results indicate that a high incidence of dysplasia was associated with E2 feeding with or without DMBA treatment in the OVX rats, whereas the incidence was low in rats fed DZ or GE and treated with DMBA, suggesting a weak estrogen receptor agonist of DZ or GE in the rat uterus. The absence of dysplasia in OVX rats exposed to DMBA alone also suggests, in part, a promotional mechanism via estrogen- or isoflavone-driven cell proliferation.
SN - 0163-5581
AD - FDA Jefferson Laboratories, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, Arkansas 72079
U2 - PMID: 16351510.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Henneberger, P. K.
T1 - How "clean" is the cleaning profession?
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2005/09//
VL - 62
IS - 9
M3 - Article
SP - 586
EP - 587
SN - 13510711
AB - Presents a discussion on the cleanliness of cleaning professionals. Risks faced by the cleaning professionals from cleaning compounds; Consideration of cleaning compounds as a risk factor for asthma; Difficulties to measure accidental peak exposures.
KW - Cleaning compounds
KW - Sanitation
KW - Asthma
KW - Cleaning personnel
KW - Hygiene
KW - Chemicals
N1 - Accession Number: 18288066; Henneberger, P. K. 1; Email Address: pkh0@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, M/S H2800 1095 Willowdale Road, Morgantown, WV 26505, USA.; Issue Info: Sep2005, Vol. 62 Issue 9, p586; Thesaurus Term: Cleaning compounds; Thesaurus Term: Sanitation; Thesaurus Term: Asthma; Subject Term: Cleaning personnel; Subject Term: Hygiene; Subject Term: Chemicals; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 561722 Janitorial services (except window cleaning); NAICS/Industry Codes: 561720 Janitorial Services; Number of Pages: 2p; Document Type: Article
L3 - 10.1136/oem.2005.020701
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106388597
T1 - How 'clean' is the cleaning profession?
AU - Henneberger PK
Y1 - 2005/09//
N1 - Accession Number: 106388597. Language: English. Entry Date: 20060127. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Medina-Ramón M, Zock JP, Kogevinas M, Sunyer J, Torralba Y, Borrell A, et al. Asthma, chronic bronchitis, and exposure to irritant agents in occupational domestic cleaning: a nested case-control study. (OCCUP ENVIRON MED) Sep2005; 62 (9): 598-606. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Occupational Exposure -- Adverse Effects
SP - 586
EP - 587
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 62
IS - 9
PB - BMJ Publishing Group
SN - 1351-0711
AD - National Institute for Occupational Safety and Health, M/S H2800 1095 Willowdale Road, Morgantown, WV 26505; pkh0@cdc.gov
U2 - PMID: 16109813.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hussain, Ajaz
T1 - The Nation Needs a Comprehensive Pharmaceutical Engineering Education and Research System.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2005/09//
VL - 29
IS - 9
M3 - Article
SP - 122
EP - 121
PB - Advanstar Communications Inc.
SN - 15432521
AB - Focuses on the efficiency and effectiveness of the pharmaceutical quality decision-making system to address the increasing complexity of pharmaceutical systems in the U.S. Importance of the pharmaceutical science education system to meet the public health objectives in the country; Means of maintaining a highly competitive environment for the pharmaceutical industry; Recognition of efforts to improve pharmaceutical science and engineering education.
KW - DECISION making
KW - PHARMACEUTICAL industry
KW - PHARMACEUTICAL technology
KW - SCIENCE -- Study & teaching
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 18172662; Hussain, Ajaz 1; Email Address: hussaina@cder.fda.gov; Affiliations: 1: Deputy Director, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, FDA, 5600 Fishers Lane, Rockville, MD 20852; Issue Info: Sep2005, Vol. 29 Issue 9, p122; Thesaurus Term: DECISION making; Thesaurus Term: PHARMACEUTICAL industry; Subject Term: PHARMACEUTICAL technology; Subject Term: SCIENCE -- Study & teaching; Subject Term: PUBLIC health; Subject: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Banks, David
AU - Woo, Emily Jane
AU - Burwen, Dale R.
AU - Perucci, Phil
AU - Braun, M. Miles
AU - Ball, Robert
T1 - Comparing data mining methods on the VAERS database.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2005/09//
VL - 14
IS - 9
M3 - Article
SP - 601
EP - 609
SN - 10538569
AB - Purpose Data mining may enhance traditional surveillance of vaccine adverse events by identifying events that are reported more commonly after administering one vaccine than other vaccines. Data mining methods find signals as the proportion of times a condition or group of conditions is reported soon after the administration of a vaccine; thus it is a relative proportion compared across vaccines, and not an absolute rate for the condition. The Vaccine Adverse Event Reporting System (VAERS) contains approximately 150 000 reports of adverse events that are possibly associated with vaccine administration. Methods We studied four data mining techniques: empirical Bayes geometric mean (EBGM), lower-bound of the EBGM's 90% confidence interval (EB05), proportional reporting ratio (PRR), and screened PRR (SPRR). We applied these to the VAERS database and compared the agreement among methods and other performance properties, particularly focusing on the vaccine-event combinations with the highest numerical scores in the various methods. Results The vaccine-event combinations with the highest numerical scores varied substantially among the methods. Not all combinations representing known associations appeared in the top 100 vaccine-event pairs for all methods. Conclusions The four methods differ in their ranking of vaccine-COSTART pairs. A given method may be superior in certain situations but inferior in others. This paper examines the statistical relationships among the four estimators. Determining which method is best for public health will require additional analysis that focuses on the true alarm and false alarm rates using known vaccine-event associations. Evaluating the properties of these data mining methods will help determine the value of such methods in vaccine safety surveillance. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709167; Banks, David 1; Woo, Emily Jane 1; Burwen, Dale R. 1; Perucci, Phil 1; Braun, M. Miles 1; Ball, Robert 1; Affiliations: 1: The Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: Sep2005, Vol. 14 Issue 9, p601; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1107
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mendelsohn, Aaron B.
AU - Governale, Laura
AU - Trontell, Anne
AU - Seligman, Paul
T1 - Changes in isotretinoin prescribing before and after implementation of the System to Manage Accutane Related Teratogenicity™ (SMART™) risk management program.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2005/09//
VL - 14
IS - 9
M3 - Article
SP - 615
EP - 618
SN - 10538569
AB - Purpose To assess changes in isotretinoin prescribing following the implementation of the System to Manage Accutane Related Teratogenicity™ (SMART™) risk management program. Methods Using nationally representative commercial data resources on prescription drug dispensing patterns, surveys of office-based physician practices, and a large, claims database from a pharmacy benefits manager (PBM), we examined the total number of isotretinoin prescriptions (new and refill), prescriber speciality, and patient characteristics (age, gender, severity of acne indication) in the year before (April 2001-March 2002) and the year following (April 2002-March 2003) implementation of the SMART™ program. Results In the 12-months prior to SMART™, 1 508 000 prescriptions were dispensed for isotretinoin, declining approximately 23% to 1 160 000 prescriptions in the year following SMART™. There was little or no change in prescriber specialty, severity of acne, and patient age and gender. Conclusion SMART™ may have lead to a decrease in isotretinoin prescriptions. Further research is needed to determine whether the reduced number of isotretinoin prescriptions reflects appropriate use or inhibited use resulting in loss of access to the product's benefits. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709158; Mendelsohn, Aaron B. 1,2; Governale, Laura 1; Trontell, Anne 1; Seligman, Paul 1; Affiliations: 1: Office of Drug Safety, Food and Drug Administration, Rockville, MD, USA; 2: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA; Issue Info: Sep2005, Vol. 14 Issue 9, p615; Number of Pages: 4p; Document Type: Article
L3 - 10.1002/pds.1111
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sharp, D. S.
AU - Ben-Shlomo, Y.
AU - Beswick, A. D.
AU - Andrew, M. E.
AU - Elwood, P. C.
T1 - Platelet aggregation in whole blood is a paradoxical predictor of ischaemic stroke: Caerphilly Prospective Study revisited.
JO - Platelets
JF - Platelets
Y1 - 2005/09//
VL - 16
IS - 6
M3 - Article
SP - 320
EP - 328
PB - Taylor & Francis Ltd
SN - 09537104
AB - The Caerphilly Prospective Study demonstrates a paradoxical association of increased ischaemic stroke risk with decreased whole blood adenosine diphosphate (ADP) induced platelet sensitivity. A reanalysis of this association examines whether other haematological indices and prevalent disease at baseline may explain this finding. There were 1506 men free of clinical cardiovascular disease at baseline, with 85 men manifesting a first ischaemic stroke event over 8.3 years of follow-up in this population-based prospective cohort study. Using two different approaches, the paradoxical findings are confirmed and associations are slightly stronger after accounting for red cell, platelet, and white cell indices. A U-shaped relation of stroke with platelet count is noted. These findings are consistent with the existence of sub-clinical endothelial disease and compensatory mechanisms down-regulating ADP-induced aggregation sensitivity. They support an allostasis model of causality for understanding the paradox. A public health approach to prevention could have measurable impact if intervention strategies can be developed to alter early stages of disease appropriate to such mechanisms of causation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Platelets is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelet aggregation
KW - ISCHEMIA
KW - BLOOD circulation disorders
KW - ADENOSINE diphosphate
KW - CEREBROVASCULAR disease
KW - ENDOTHELIUM
KW - adenosine diphosphate
KW - allostasis
KW - epidemiology
KW - Platelet aggregation
KW - stroke
KW - thrombosis
N1 - Accession Number: 18406081; Sharp, D. S. 1; Email Address: dsharp@cdc.gov Ben-Shlomo, Y. 2 Beswick, A. D. 2,3 Andrew, M. E. 1 Elwood, P. C. 3; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA 2: Department of Social Medicine, University of Bristol, Bristol, UK 3: Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff, UK; Source Info: Sep2005, Vol. 16 Issue 6, p320; Subject Term: BLOOD platelet aggregation; Subject Term: ISCHEMIA; Subject Term: BLOOD circulation disorders; Subject Term: ADENOSINE diphosphate; Subject Term: CEREBROVASCULAR disease; Subject Term: ENDOTHELIUM; Author-Supplied Keyword: adenosine diphosphate; Author-Supplied Keyword: allostasis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: Platelet aggregation; Author-Supplied Keyword: stroke; Author-Supplied Keyword: thrombosis; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/09537100500124491
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pelletie, John R.
AU - Nguyen, Meeta
AU - Bradley, Kevin
AU - Johnsen, Matthew
AU - McKay, Colleen
T1 - A STUDY OF A STRUCTURED EXERCISE PROGRAM WITH MEMBERS OF AN ICCD CERTIFIED CLUBHOUSE: PROGRAM DESIGN, BENEFITS, AND IMPLICATIONS FOR FEASIBILITY.
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
Y1 - 2005///Fall2005
VL - 29
IS - 2
M3 - Article
SP - 89
EP - 96
SN - 1095158X
AB - Individuals with serious mental illness (SMI) have significantly greater risk of comorbid health problems and premature death, and there is need for interventions that can improve physical fitness and overall health. Accordingly, a study was conducted which evaluated the effectiveness of a structured physical exercise program that was developed as part of a wellness project in an ICCD Certified Clubhouse. Seventeen clubhouse members completed a 16-week program with evidence of significant improvement in aerobic capacity and perceived mental health as well as positive trends in perceived improvements in physical and social functioning. Qualitative data indicated satisfaction with the program by all participants, especially the value of group support, while also highlighting the need for greater attention to nutrition as part of a future program. Moreover, the study found that a structured exercise program can be successfully provided to members of an ICCD Certified Clubhouse. [ABSTRACT FROM AUTHOR]
AB - Copyright of Psychiatric Rehabilitation Journal is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL illness
KW - MENTAL health
KW - HEALTH promotion
KW - PHYSICAL fitness
KW - PUBLIC health
N1 - Accession Number: 18659863; Pelletie, John R. 1 Nguyen, Meeta 2 Bradley, Kevin 3 Johnsen, Matthew 4 McKay, Colleen 5; Affiliation: 1: Associate Professor, Institute for Social and Rehabilitation Services, Assumption College. 2: Physician Specializing in Preventative Medicine, Serves on the staff of the Greater Lawrence Community Health Center. 3: Executive Director of the Genesis Club, Inc. 4: Research Associate Professor, Center for Mental Health Services Research, University of Massachusetts, Medical School. 5: Research Instructor and Program Director of the Program for Clubhouse Research, Center for Mental Health Services Research, University of Massachusetts, Medical School.; Source Info: Fall2005, Vol. 29 Issue 2, p89; Subject Term: MENTAL illness; Subject Term: MENTAL health; Subject Term: HEALTH promotion; Subject Term: PHYSICAL fitness; Subject Term: PUBLIC health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106375672
T1 - SAMHSA's commitment to eliminating the use of seclusion and restraint.
AU - Curie CG
Y1 - 2005/09//
N1 - Accession Number: 106375672. Language: English. Entry Date: 20060106. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Patient Seclusion -- Methods
KW - Patient Seclusion -- Utilization
KW - Restraint, Physical -- Methods
KW - Restraint, Physical -- Utilization
KW - Substance Abuse and Mental Health Services Administration
KW - Trauma -- Etiology
KW - Trauma -- Prevention and Control
KW - Violence -- Prevention and Control
SP - 1139
EP - 1140
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 56
IS - 9
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Administrator, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, MD 20857; charles.curie@samhsa.hhs.gov
U2 - PMID: 16148330.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Provan, Keith G.1, kprovan@eller.arizona.edu
AU - Veazie, Mark A.2, mark.veazie@ihs.gov
AU - Staten, Lisa K.1, staten@u.arizona.edu
AU - Teufel-Shone, Nicolette I.1, eufel@u.arizona.edu
T1 - The Use of Network Analysis to Strengthen Community Partnerships.
JO - Public Administration Review
JF - Public Administration Review
J1 - Public Administration Review
PY - 2005/09//Sep/Oct2005
Y1 - 2005/09//Sep/Oct2005
VL - 65
IS - 5
CP - 5
M3 - Article
SP - 603
EP - 613
SN - 00333352
AB - Community partnerships or networks of collaborating public and nonprofit organizations are an important way of addressing a wide range of problems and needs that communities face. In the academic literature, network analysis has been used to analyze and understand the structure of the relationships that make up multiorganizational partnerships. But this tool is not well-known outside the small group of researchers who study networks, and it is seldom used as a method of assisting communities. This article briefly discusses network analysis and how community leaders can use the results generated by this tool to strengthen relationships among public and nonprofit organizations, thereby building the community's capacity to address critical needs in areas such as health, human services, social problems, and economic development. [ABSTRACT FROM AUTHOR]
KW - Community development
KW - Economic development
KW - Associations, institutions, etc.
KW - Social problems
KW - Public-private sector cooperation
KW - Public administration
KW - Nonprofit organizations
KW - Human services
N1 - Accession Number: 18353696; Authors:Provan, Keith G. 1 Email Address: kprovan@eller.arizona.edu; Veazie, Mark A. 2 Email Address: mark.veazie@ihs.gov; Staten, Lisa K. 1 Email Address: staten@u.arizona.edu; Teufel-Shone, Nicolette I. 1 Email Address: eufel@u.arizona.edu; Affiliations: 1: University of Arizona; 2: Indian Health Service; Subject: Public-private sector cooperation; Subject: Public administration; Subject: Nonprofit organizations; Subject: Community development; Subject: Economic development; Subject: Associations, institutions, etc.; Subject: Human services; Subject: Social problems; Author-Supplied Keyword: Administrative Structure and Organization; Author-Supplied Keyword: Structure, Organization, and Network; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts; Record Type: Article
L3 - 10.1111/j.1540-6210.2005.00487.x
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DP - EBSCOhost
DB - eft
ER -
TY - JOUR
AU - Torm, Siiri
AU - Meriste, Sirli
AU - Tamm, Eda
AU - Alusalu, Sirje
AU - Järviste, Antonina
AU - Lang, Katrin
T1 - Pertussis outbreak in a basic school in Estonia: Description, contributing factors and vaccine effectiveness.
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
Y1 - 2005/09//
VL - 37
IS - 9
M3 - Article
SP - 664
EP - 668
PB - Taylor & Francis Ltd
SN - 00365548
AB - The aim of the current study was to assess the epidemiological situation concerning the emergence of a pertussis outbreak, as well as potential contributing factors and vaccine effectiveness. A retrospective epidemiological description and an analysis of the outbreak among students were performed. The basic school in Adavere had a total of 150 students in 2003. Of these, 54 cases of pertussis, with median age 12 y, all corresponding to clinical case definition, were identified with an attack rate of 36%. Regarding confirmation of the diagnosis, out of all clinical cases, 18 were confirmed by laboratory testing (2 by isolation of B. pertussis and 16 serologically based on single sera) and 36 with epidemiological linkage only. Of all the students with pertussis, 35 (65%) had received 4 doses and 6 (11%) 3 doses of DTwP vaccine; 13 (24%) students had received fewer than 3 doses or were unvaccinated. The contributing factors in generating this outbreak were close epidemiological contacts, late identification of pertussis diagnosis in the primary, secondary and later cases, as well as a too late initiated active surveillance. In this outbreak, low vaccine effectiveness and low vaccination coverage also played an important role. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Infectious Diseases is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WHOOPING cough
KW - VACCINATION
KW - EPIDEMIOLOGY
KW - EPIDEMICS
KW - COUGH
KW - ESTONIA
N1 - Accession Number: 18289178; Torm, Siiri 1 Meriste, Sirli 1 Tamm, Eda 1 Alusalu, Sirje 2 Järviste, Antonina 3 Lang, Katrin 4; Email Address: Katrin.Lang@ut.ee; Affiliation: 1: Department of Infectious Diseases, Tartu University Clinics Children's Clinic, Estonia. 2: Adavere Family Practice Centre, University of Tartu, Estonia. 3: Public Health Service of Tartu, Department of Jõgeva County, University of Tartu, Estonia. 4: Department of Public Health, University of Tartu, Estonia.; Source Info: Sep2005, Vol. 37 Issue 9, p664; Subject Term: WHOOPING cough; Subject Term: VACCINATION; Subject Term: EPIDEMIOLOGY; Subject Term: EPIDEMICS; Subject Term: COUGH; Subject Term: ESTONIA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/00365540510044454
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18289178&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Götz, Hannelore M.
AU - Veldhuijzen, Irene K.
AU - van Bergen, Jan E. A. M.
AU - Hoebe, Christian J. P. A.
AU - de Zwart, Onno
AU - Richardus, Jan H.
AU - Broer, J.
AU - Coenen, A. J. J.
AU - de Groot, F.
AU - van Schaik, D. T.
AU - Verhooren, M. J. C.
T1 - Acceptability and Consequences of Screening for Chlamydia trachomatis by Home-Based Urine Testing.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2005/09//
VL - 32
IS - 9
M3 - Article
SP - 557
EP - 562
SN - 01485717
AB - Objective: The objective of this study was to study the acceptability and consequences of home-based chlamydia (CT) screening by Municipal Health Services (MHS) among 15- to 29-year-old participants. Study: This study consisted of a cross-section of 156 CT-positives and 600 random sampled CT-negatives after receiving the result of their CT test. Results: Thirty-eight percent of the men and 59% of the women responded. The screening method was well-accepted. Seventy percent (52) of the CT-positives were surprised about their result. Infected women more often than men reported a feeling of being dirty and of anxiety about infertility. Curiosity for the CT result was decisive for participation In 68% and perception of personal risk was poor. The willingness to be tested regularly was determined by present chlamydial infection, young age, multiple lifetime partners, short relationship, and earlier test for chlamydia. Conclusions: Chlamydia screening organised by MHS is acceptable for future screening. Participants with an elevated risk are interested in screening as long as test kits are easily available. Counseling with focus on effects of CT, especially on women, is essential. Alternative approaches are needed to motivate men and non-Dutch high-risk groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Diseases is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlamydia
KW - Public health
KW - Chlamydia infections -- Diagnosis
KW - Urinalysis
KW - Medical screening
KW - Diagnosis
N1 - Accession Number: 18123784; Götz, Hannelore M. 1; Email Address: gotzh@ggd.rotterdam.nl; Veldhuijzen, Irene K. 1; van Bergen, Jan E. A. M. 2; Hoebe, Christian J. P. A. 3; de Zwart, Onno 1; Richardus, Jan H. 1,4; Broer, J. 5; Coenen, A. J. J. 2; de Groot, F. 5; van Schaik, D. T. 2; Verhooren, M. J. C. 6; Affiliations: 1: Municipal Public Health Service, Rotterdam, Netherlands; 2: STI AIDS Netherlands, Amsterdam, Netherlands; 3: Municipal Public Health Service, Eastern South Limburg, Netherlands; 4: Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, Rotterdam, Netherlands; 5: Municipal Public Health Service, Groningen, Netherlands; 6: Municipal Public Health Service, “Hart voor Brabant,”, Netherlands; Issue Info: Sep2005, Vol. 32 Issue 9, p557; Thesaurus Term: Chlamydia; Thesaurus Term: Public health; Subject Term: Chlamydia infections -- Diagnosis; Subject Term: Urinalysis; Subject Term: Medical screening; Subject Term: Diagnosis; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
L3 - 10.1097/01.olq.0000175416.15905.db
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18123784&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jian Yan
AU - Qingsu Xia
AU - Shu-Hui Cherng
AU - Wamer, Wayne G.
AU - Howard, Paul C.
AU - Hongtao Yu
AU - Fu, Peter P.
T1 - Photo-induced DNA damage and photocytotoxicity of retinyl palmitate and its photodecomposition products.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2005/09//
VL - 21
IS - 7/8
M3 - Article
SP - 167
EP - 175
PB - Sage Publications, Ltd.
SN - 07482337
AB - Retinyl palmitate (RP) is an ester of retinol (vitamin A) and the predominant form of retinol found endogenously in the skin. We have previously reported that photoirradiation of RP with UVA light resulted in the formation of anhydroretinol (AR), 5,6-epoxyretinyl palmitate (5,6-epoxy-RP) and other photodecomposition products. While AR was formed through an ionic photodissociation mechanism, 5,6-epoxy-RP was formed through a light-mediated, free radical-initiated chain reaction. In the current study, the phototoxicity of RP, AR and 5,6-epoxy-RP in human skin Jurkat T-cells with and without light irradiation was determined using a fluorescein diacetate assay. Under similar conditions, the Comet assay was used to assess damage to cellular DNA. Nuclear DNA was not significantly damaged when the cells were irradiated by UVA plus visible light in the absence of a retinoid; however, when the cells were illuminated with UVA plus visible light in the presence of either RP, 5,6-epoxy-RP or AR (50, 100, 150 and 200 μM), DNA fragmentation was observed. Cell death was observed for retinoid concentrations of 100 μM or higher. When treated with 150 μM of RP, 5,6-epoxy-RP or AR, cell death was 52, 33 and 52%, respectively. These results suggest that RP and its two photodecomposition products, AR and 5,6-epoxy-RP, induce DNA damage and cytotoxicity when irradiated with UVA plus visible light. We also determined that photoirradiation of RP, AR and 5,6-epoxy-RP causes single strand breaks in supercoiled ΦX174 plasmid DNA. Using a constant dose of UVA light (50 J/cm2), the level of DNA cleavage was highest in the presence of AR, followed by 5,6-epoxy-RP, then RP. The induced DNA strand cleavage was inhibited by NaN3. These results suggest that photoirradiation of RP, 5,6-epoxy-RP and AR with UVA light generates free radicals that initiate DNA strand cleavage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN A
KW - DNA damage
KW - PALMITIC acid
KW - DECOMPOSITION (Chemistry)
KW - BIOCHEMICAL genetics
KW - SCISSION (Chemistry)
KW - 5
KW - 5, 6-EPOXY-RETINYL PALMITATE
KW - 6-epoxy-retinyl palmitate
KW - anhydroretinol
KW - Comet assay
KW - DNA STRAND CLEAVAGE
KW - retinyl palmitate
N1 - Accession Number: 17566051; Jian Yan 1,2 Qingsu Xia 1 Shu-Hui Cherng 1 Wamer, Wayne G. 3 Howard, Paul C. 1 Hongtao Yu 2 Fu, Peter P. 1; Email Address: yu@ccaix.jsums.edu; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. 2: Department of Chemistry, Jackson State University, Jackson, MS, USA. 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA.; Source Info: 2005, Vol. 21 Issue 7/8, p167; Subject Term: VITAMIN A; Subject Term: DNA damage; Subject Term: PALMITIC acid; Subject Term: DECOMPOSITION (Chemistry); Subject Term: BIOCHEMICAL genetics; Subject Term: SCISSION (Chemistry); Author-Supplied Keyword: 5; Author-Supplied Keyword: 5, 6-EPOXY-RETINYL PALMITATE; Author-Supplied Keyword: 6-epoxy-retinyl palmitate; Author-Supplied Keyword: anhydroretinol; Author-Supplied Keyword: Comet assay; Author-Supplied Keyword: DNA STRAND CLEAVAGE; Author-Supplied Keyword: retinyl palmitate; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1191/0748233705th225oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17566051&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - B'Hymer, Clayton
AU - Keil, Deborah
AU - Cheever, Kenneth
T1 - A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2005/09//Sep/Oct2005
VL - 15
IS - 5
M3 - Article
SP - 367
EP - 373
PB - Taylor & Francis Ltd
SN - 15376516
AB - A test procedure for the determination of (2-methoxyethoxy)acetic acid (MEAA) was adapted and applied to urine samples from jet fuel (JP-8)-exposed mice using capillary gas chromatography with a mass selective detector (MSD). MEAA is a metabolite and proposed biomarker for exposure to 2-(2-methoxyethoxy)ethanol, a glycol ether component in the formulation of JP-8. The collected urine samples were spiked with deuterated butoxyacetic acid internal standard, and extracted with ethyl acetate, and esterified with ethanol and sulfuric acid, and the esters of the glycol ethers were extracted with methylene chloride. The chromatographic conditions used easily separate the MEAA ethyl ester from interferences within mouse urine. The application of this procedure to urine samples collected from mice demonstrated that MEAA was detectable after oral (2000 mg/kg) or dermal (50 μ L) exposure for 7 days to JP-8 at levels as high as 8.5 or 6.5 μ g/mL, respectively. This pilot demonstration indicated that total urinary MEAA was a viable biomarker for the two routes of JP-8 exposure in laboratory mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL experimentation
KW - ACETIC acid
KW - MICE
KW - URINE
KW - JET planes -- Fuel
KW - GAS chromatography
KW - (2-Methoxyethoxy) acetic Acid
KW - (2-Methoxyethoxy)acetic Acid
KW - GC-MS
KW - Glycol Ethers
KW - Jet Fuel
KW - JP-8
KW - MEAA
N1 - Accession Number: 18685572; B'Hymer, Clayton 1,2; Email Address: cbhymer@cdc.gov Keil, Deborah 1,3 Cheever, Kenneth 1,2; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, Ohio, USA 45226 2: Division of Applied Research and Technology, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, Ohio, USA 45226 3: Agriculture and Immunotoxicology Group, 1095 Willowdale Drive, Morgantown, West Virginia, USA 26505; Source Info: Sep/Oct2005, Vol. 15 Issue 5, p367; Subject Term: ANIMAL experimentation; Subject Term: ACETIC acid; Subject Term: MICE; Subject Term: URINE; Subject Term: JET planes -- Fuel; Subject Term: GAS chromatography; Author-Supplied Keyword: (2-Methoxyethoxy) acetic Acid; Author-Supplied Keyword: (2-Methoxyethoxy)acetic Acid; Author-Supplied Keyword: GC-MS; Author-Supplied Keyword: Glycol Ethers; Author-Supplied Keyword: Jet Fuel; Author-Supplied Keyword: JP-8; Author-Supplied Keyword: MEAA; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/153765291009976
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18685572&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meseda, Clement A.
AU - Garcia, Alonzo D.
AU - Kumar, Arunima
AU - Mayer, Anne E.
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Golding, Hana
AU - Merchlinsky, Michael
AU - Weir, Jerry P.
T1 - Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model
JO - Virology
JF - Virology
Y1 - 2005/09//
VL - 339
IS - 2
M3 - Article
SP - 164
EP - 175
SN - 00426822
AB - Abstract: Significant adverse events are associated with vaccination with the currently licensed smallpox vaccine. Candidate new-generation smallpox vaccines such as the replication-defective modified vaccinia virus Ankara (MVA) produce very few adverse events in experimental animals and in limited human clinical trials conducted near the end of the smallpox eradication campaign. Efficacy evaluation of such new-generation vaccines will be extraordinarily complex, however, since the eradication of smallpox precludes a clinical efficacy trial and the correlates of protection against smallpox are unknown. A combination of relevant animal efficacy studies along with thorough comparative immunogenicity studies between traditional and new-generation smallpox vaccines will be necessary for vaccine licensure. In the present study, a variety of immune responses elicited by MVA and the licensed smallpox vaccine Dryvax in a murine model were compared, with a focus on mimicking conditions and strategies likely to be employed in human vaccine trials. Immunization of mice with MVA, using several relevant vaccination routes including needle-free delivery, elicited humoral and cellular immune responses qualitatively similar to those elicited by vaccination with Dryvax. Similar levels of vaccinia-specific IgG and neutralizing antibody were elicited by Dryvax and MVA when higher doses (approximately 1 log) of MVA were used for immunization. Antibody levels peaked at about 6 weeks post-immunization and remained stable for at least 15 weeks. A booster immunization of either MVA or Dryvax following an initial priming immunization with MVA resulted in an enhanced IgG titer and neutralizing antibody response. In addition, both Dryvax and various MVA vaccination protocols elicited antibody responses to the extracellular enveloped form of the virus and afforded protection against a lethal intranasal challenge with vaccinia virus WR. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - VIRUSES
KW - SMALLPOX vaccine
KW - PREVENTIVE medicine
KW - Dryvax
KW - Modified vaccinia virus Ankara
KW - Smallpox vaccination
KW - Vaccine immunogenicity
N1 - Accession Number: 18236157; Meseda, Clement A. 1 Garcia, Alonzo D. 1 Kumar, Arunima 1 Mayer, Anne E. 1 Manischewitz, Jody 2 King, Lisa R. 2 Golding, Hana 2 Merchlinsky, Michael 1 Weir, Jerry P. 1; Email Address: weirj@cber.fda.gov; Affiliation: 1: Laboratory of DNA Viruses, Division of Viral Products, HFM-457 Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20892, USA 2: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Sep2005, Vol. 339 Issue 2, p164; Subject Term: VACCINATION; Subject Term: VIRUSES; Subject Term: SMALLPOX vaccine; Subject Term: PREVENTIVE medicine; Author-Supplied Keyword: Dryvax; Author-Supplied Keyword: Modified vaccinia virus Ankara; Author-Supplied Keyword: Smallpox vaccination; Author-Supplied Keyword: Vaccine immunogenicity; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.virol.2005.06.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18236157&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-13514-003
AN - 2005-13514-003
AU - Pelletier, John R.
AU - Nguyen, Meeta
AU - Bradley, Kevin
AU - Johnsen, Matthew
AU - McKay, Colleen
T1 - A Study of a Structured Exercise Program with Members of an ICCD Certified Clubhouse: Program Design, Benefits, and Implications for Feasibility.
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2005///Fal 2005
VL - 29
IS - 2
SP - 89
EP - 96
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Pelletier, John R., Institude For Social & Rehab Services, Assumption College, 500 Salibury St, Worcester, MA, US, 01609
N1 - Accession Number: 2005-13514-003. PMID: 16268003 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Pelletier, John R.; Institude for Social and Rehabilitation Services, Assumption College, Worcesten, MA, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20060109. Correction Date: 20150824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Death and Dying; Exercise; Mental Disorders; Therapeutic Social Clubs. Minor Descriptor: Health; Physical Fitness. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: SF-36 Health Survey. Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Fal 2005.
AB - Individuals with serious mental illness (SMI) have significantly greater risk of comorbid health problems and premature death, and there is need for interventions that can improve physical fitness and overall health. Accordingly, a study was conducted which evaluated the effectiveness of a structured physical exercise program that was developed as part of a wellness project in an ICCD Certified Clubhouse. Seventeen clubhouse members completed a i6-week program with evidence of significant improvement in aerobic capacity and perceived mental health as well as positive trends in perceived improvements in physical and social functioning. Qualitative data indicated satisfaction with the program by all participants, especially the value of group support, while also highlighting the need for greater attention to nutrition as part of a future program. Moreover, the study found that a structured exercise program can be successfully provided to members of an ICCD Certified Clubhouse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - structured exercise program
KW - serious mental illness
KW - comorbidity
KW - premature death
KW - certified clubhouse
KW - 2005
KW - Comorbidity
KW - Death and Dying
KW - Exercise
KW - Mental Disorders
KW - Therapeutic Social Clubs
KW - Health
KW - Physical Fitness
KW - 2005
DO - 10.2975/29.2005.89.96
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13514-003&site=ehost-live&scope=site
UR - jpelleti@assumption.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13666-011
AN - 2005-13666-011
AU - Foley, Kevin
AU - Duran, Bonnie
AU - Morris, Priscilla
AU - Lucero, Julie
AU - Jiang, Yizhou
AU - Baxter, Bonita
AU - Harrison, Melvin
AU - Shurley, Maynard
AU - Shorty, Ed
AU - Joe, Darrell
AU - Iralu, Jonathan
AU - Davidson-Stroh, Lynn
AU - Foster, Larry
AU - Mae-Gilene, Begay
AU - Sonleiter, Nancy
T1 - Using motivational interviewing to promote HIV testing at an American Indian substance abuse treatment facility.
T3 - Faces of HIV/AIDS and Substance Abuse in Native American Communities
JF - Journal of Psychoactive Drugs
JO - Journal of Psychoactive Drugs
JA - J Psychoactive Drugs
Y1 - 2005/09//
VL - 37
IS - 3
SP - 321
EP - 329
CY - US
PB - Haight-Ashbury Publications
SN - 0279-1072
SN - 2159-9777
AD - Duran, Bonnie, University of New Mexico, MSC09 5060, 1 University of New Mexico, Albuquerque, NM, US, 87231
N1 - Accession Number: 2005-13666-011. PMID: 16295016 Other Journal Title: Journal of Psychedelic Drugs. Partial author list: First Author & Affiliation: Foley, Kevin; Nainizhoozhi Center Inc., US. Other Publishers: Taylor & Francis. Release Date: 20060123. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; American Indians; HIV Testing; Interviewing; Motivation. Minor Descriptor: AIDS; Alaska Natives; Drug Abuse; Drug Rehabilitation; Motivational Interviewing; Risk Factors. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2005.
AB - Alcohol and drug use are associated with increased risk of HIV/AIDS. American Indians and Alaska Natives (AI/AN) have high rates of alcohol and other drug use, as well as a high incidence of unsafe sex behaviors and injection drug use practices. Indicators of AI/AN HIV risks involving sexual activity include high rates of STDs, such as gonorrhea, chlamydia, and syphilis. Despite these facts, the prevalence of HIV infection among AI/AN is not well known. The present study is part of a HRSA-funded SPNS HIV/AIDS health initiative, one goal of which is to increase the number of HIV-positive individuals who know their HIV status. To meet the goal of the SPNS project, patients in an inpatient alcohol and drug treatment center were provided with an HIV prevention educational presentation followed by one-on-one HIV counseling. Motivational interviewing was used in the counseling sessions to aid participants in recognizing their risk status and making a decision to be HIV tested. Results show that of the 134 who agreed to one-on-one HIV counseling and 105 (78%) returned for their results. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - motivational interviewing
KW - HIV testing
KW - American Indian substance abuse treatment facility
KW - risk factors
KW - 2005
KW - AIDS Prevention
KW - American Indians
KW - HIV Testing
KW - Interviewing
KW - Motivation
KW - AIDS
KW - Alaska Natives
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Motivational Interviewing
KW - Risk Factors
KW - 2005
DO - 10.1080/02791072.2005.10400526
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13666-011&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-12609-001
AN - 2005-12609-001
AU - Wolff, Nancy
AU - Clark, Robin
ED - Wolff, Nancy
ED - Clark, Robin
T1 - Editorial: Money, innovation, and access: The mental health system in motion.
T3 - Economics Of Access To Mental Health Treatment
JF - International Journal of Law and Psychiatry
JO - International Journal of Law and Psychiatry
JA - Int J Law Psychiatry
Y1 - 2005/09//Sep-Oct, 2005
VL - 28
IS - 5
SP - 457
EP - 466
CY - Netherlands
PB - Elsevier Science
SN - 0160-2527
SN - 1873-6386
AD - Wolff, Nancy, Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2005-12609-001. PMID: 16153711 Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20051114. Correction Date: 20170206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Drug Therapy; Health Care Costs; Mental Disorders; Mental Health Services; Psychosocial Rehabilitation. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: Sep-Oct, 2005.
AB - In this special issue of International Journal of Law and Psychiatry, attention is focused on the mental health care market in the United States, Canada, and the United Kingdom, with emphasis on how its financing has interacted with the profit motive and the public's interest to foster and inhibit access to psychotropic medications and psychosocial treatments over the past 50 years. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - psychosocial treatments
KW - mental illness
KW - psychotropic medications
KW - health systems
KW - treatment outcomes
KW - mental health services
KW - 2005
KW - Drug Therapy
KW - Health Care Costs
KW - Mental Disorders
KW - Mental Health Services
KW - Psychosocial Rehabilitation
KW - 2005
DO - 10.1016/j.ijlp.2005.08.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12609-001&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-09660-002
AN - 2005-09660-002
AU - Schrader, Steven M.
T1 - Research on Bicycle Saddles and Sexual Health Comes of Age.
JF - Journal of Sexual Medicine
JO - Journal of Sexual Medicine
JA - J Sex Med
Y1 - 2005/09//
VL - 2
IS - 5
SP - 594
EP - 595
CY - United Kingdom
PB - Blackwell Publishing
SN - 1743-6095
SN - 1743-6109
N1 - Accession Number: 2005-09660-002. PMID: 16422815 Partial author list: First Author & Affiliation: Schrader, Steven M.; Reproductive Health Assessment, National Institute for Occupational Safety and Health, US. Other Publishers: Elsevier Science; Wiley-Blackwell Publishing Ltd. Release Date: 20051121. Correction Date: 20160229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Erectile Dysfunction; Human Factors Engineering; Intervention; Pathophysiology. Minor Descriptor: Erection (Penis); Exercise. Classification: Medical Treatment of Physical Illness (3363); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Sep, 2005.
AB - This editorial discusses the research presented in this issue of The Journal of Sexual Medicine dealing with a relationship between bicycle saddles and sexual health and erectile dysfunction. The evidence-based review by V. Huang et al. (see record [rid]2005-09660-003[/rid]) demonstrates this relationship, noting that research is focused on the pathophysiology of the erectile problem. The articles by G. Breda (see record [rid]2005-09660-004[/rid]) and R. Munarriz et al. (see record [rid]2005-09660-005[/rid]) take this knowledge to the next step: intervention. The next steps are clear. Effective strategies based on sound ergonomics and urogenital physiologic principles and testing are needed to reduce the risk of erectile dysfunction from bicycle riding. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - erectile dysfunction
KW - sexual health
KW - bicycle saddles
KW - pathophysiology
KW - intervention strategies
KW - ergonomics
KW - 2005
KW - Erectile Dysfunction
KW - Human Factors Engineering
KW - Intervention
KW - Pathophysiology
KW - Erection (Penis)
KW - Exercise
KW - 2005
DO - 10.1111/j.1743-6109.2005.00114.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-09660-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-14607-008
AN - 2005-14607-008
AU - Scallet, Andrew C.
AU - Schmued, Larry C.
AU - Johannessen, Jan N.
T1 - Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid.
T3 - Marine and freshwater toxin impacts on neurobehavioral function
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2005/09//Sep-Oct, 2005
VL - 27
IS - 5
SP - 745
EP - 752
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Scallet, Andrew C., Division of Neurotoxicology, National Center for Toxicological Research, FDA 3900 NCTR Drive, Jefferson, AR, US, 72079
N1 - Accession Number: 2005-14607-008. PMID: 16203121 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Scallet, Andrew C.; Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20060130. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Biological Markers; Food; Glutamic Acid; Kainic Acid; Neurotoxicity. Minor Descriptor: Rats. Classification: Psychopharmacology (2580); Environmental Toxins & Health (3280). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep-Oct, 2005.
AB - Domoic acid and its potent excitotoxic analogues glutamic acid and kainic acid, are synthesized by marine algae such as seaweed and phytoplankton. During an algal bloom, domoic acid may enter the food web through its consumption by a variety of marine organisms held in high regard as seafoods by both animals and humans. These seafoods include clams, mussels, oysters, anchovies, sardines, crabs, and scallops, among others. Animals, such as pelicans, cormorants, loons, grebes, sea otters, dolphins, and sea lions, which consume seafood contaminated with domoic acid, suffer disorientation and often death. Humans consuming contaminated seafood may suffer seizures, amnesia and also sometimes death. In addition to analytical measurement of domoic acid exposure levels in algae and/or seafood, it is useful to be able to identify the mode of toxicity through post-mortem evaluation of the intoxicated animal. In the present study, using the rat as an animal model of domoic acid intoxication, we compared histochemical staining of the limbic system and especially the hippocampus with degeneration-selective techniques (Fluoro-Jade and silver), a conventional Nissl stain for cytoplasm (Cresyl violet), a myelin-selective stain (Black-Gold), an astrocyte-specific stain (glial fibrillary acidic protein), early/immediate gene responses (c-Fos and c-Jun), as well as for heat shock protein (HSP-72) and blood-brain barrier integrity (rat IgG). The results demonstrate that the degeneration-selective stains are the biomarkers of domoic acid neurotoxicity that are the most useful and easy to discern when screening brain sections at low magnification. We also observed that an impairment of blood-brain barrier integrity within the piriform cortex accompanied the onset of domoic acid neurotoxicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurohistochemical biomarkers
KW - marine neurotoxicant
KW - domoic acid
KW - glutamic acid
KW - kainic acid
KW - marine algae
KW - seafoods
KW - intoxication
KW - 2005
KW - Biological Markers
KW - Food
KW - Glutamic Acid
KW - Kainic Acid
KW - Neurotoxicity
KW - Rats
KW - 2005
DO - 10.1016/j.ntt.2005.06.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-14607-008&site=ehost-live&scope=site
UR - AScallet@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10937-003
AN - 2005-10937-003
AU - Lyons-Warren, A.
AU - Chang, J. J.
AU - Balkissoon, R.
AU - Kamiya, A.
AU - Garant, M.
AU - Nurnberger, J.
AU - Scheftner, W.
AU - Reich, T.
AU - McMahon, F.
AU - Kelsoe, J.
AU - Gershon, E.
AU - Coryell, W.
AU - Byerley, W.
AU - Berrettini, W.
AU - DePaulo, R.
AU - McInnis, M.
AU - Sawa, A.
T1 - Evidence of association between bipolar disorder and Citron on chromosome 12q24.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2005/09//
VL - 10
IS - 9
SP - 807
EP - 809
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Sawa, A., Department of Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe St. Meyer 2-181, Baltimore, MD, US, 21287
N1 - Accession Number: 2005-10937-003. PMID: 15983625 Partial author list: First Author & Affiliation: Lyons-Warren, A.; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20051003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Bipolar Disorder; Chromosomes; Genes; Genetics; Polymorphism. Classification: Affective Disorders (3211). Population: Human (10). Tests & Measures: Family-Based Association Test. Methodology: Empirical Study; Quantitative Study. Page Count: 3. Issue Publication Date: Sep, 2005.
AB - Presents a letter to the editor discussing evidence of association between bipolar disorder and Citron on chromosome 12q24. This study tested for association in the National Institutes of Mental Health (NIMH) Genetics Initiative wave 3 and wave 4 pedigrees. The sample set available consisted of 307 nuclear families consisting of 1012 individuals, including probands diagnosed with BPI, BPII, (Bipolar disorder) schizoaffective disorder, or unipolar depression. Seven common single nucleotide polymorphisms (SNPs) were chosen roughly equidistant across the 195kb Citron gene. Individuals with unlikely recombination events and families with Mendelian errors were excluded from the analysis. Marker-to-marker linkage disequilibrium (LD) and Hardy-Weinberg equilibrium were determined using Haploview. Pedigrees were analyzed for the presence of association using the Family-Based Association Test (FBAT), a version of a transmission disequilibrium. This study provides the first evidence of a candidate gene for BP on chromosome 12q24, a linkage locus for BP common to many studies. The evidence suggests a possible association of the Citron gene and BP in a family-based sample set. Of particular interest are two SNPs (rs203368 and rs435136) in the proximity of exons that code for the DISC1 binding domain on Citron. The studies warrant further study of Citron and adjacent genes in larger samples and in other ethnic groups in the investigation of a possible etiology for major mood disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bipolar disorder
KW - Citron gene
KW - polymorphisms
KW - chromosomes
KW - 2005
KW - Bipolar Disorder
KW - Chromosomes
KW - Genes
KW - Genetics
KW - Polymorphism
KW - 2005
DO - 10.1038/sj.mp.4001703
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10937-003&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - asawa1@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10219-005
AN - 2005-10219-005
AU - Parrish, Alan R.
AU - Oliver, Sandra
AU - Jenkins, Donald
AU - Ruscio, Bruce
AU - Green, J. Ben
AU - Colenda, Christopher
T1 - A Short Medical School Course on Responding to Bioterrorism and Other Disasters.
JF - Academic Medicine
JO - Academic Medicine
JA - Acad Med
Y1 - 2005/09//
VL - 80
IS - 9
SP - 820
EP - 823
CY - US
PB - Lippincott Williams & Wilkins
SN - 1040-2446
SN - 1938-808X
AD - Colenda, Christopher, College of Medicine, Texas A&M University System Health Science Center, College Station, TX, US, 77843-1114
N1 - Accession Number: 2005-10219-005. PMID: 16123460 Other Journal Title: Journal of Medical Education. Partial author list: First Author & Affiliation: Parrish, Alan R.; College of Medicine, Texas A&M University System Health Science Centre, College Station, TX, US. Release Date: 20051205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Curriculum; Disasters; Emergency Services; Health Care Services; Terrorism. Minor Descriptor: Bioterrorism; Medical Education; Schools. Classification: Professional Education & Training (3410). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 4. Issue Publication Date: Sep, 2005.
AB - The events of 9/11 highlighted the limitations of the United States health care system in responding to large-scale public health emergencies. The key for an effective response to any mass casualty event is preparedness; thus, the education of medical students has become a priority. The Association of American Medical Colleges (AAMC) recommended that the nation's medical schools should thoroughly educate students about the public health and emergency services systems to ensure coordinated responses to weapons of mass destruction or other public health threats. In response, The Texas A&M University System Health Science Center College of Medicine, partnering with the Defense Institute for Medical Operations (DIMO), developed a one-week block of required (but not graded) instruction, the 'Leadership Course in Disaster Response,' first given in 2003-04 to 72 second-year students and taught by six military experts from DIMO. The course goal is to (1) educate students on resources available for regional disaster response; (2) define principles of resource management in disaster response; (3) identify specific agents associated with bioterrorism; and (4) understand the psychosocial aspects of disasters. The course was well received, and the 2004-05 session was improved, based on student and faculty feedback. The authors describe the details of the course (specifically, how the course was tailored to fit the AAMC guidelines), changes in students' knowledge and attitudes, and how the course was improved. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - short medical school course
KW - bioterrorism responses
KW - health care system
KW - disasters
KW - 2005
KW - Curriculum
KW - Disasters
KW - Emergency Services
KW - Health Care Services
KW - Terrorism
KW - Bioterrorism
KW - Medical Education
KW - Schools
KW - 2005
DO - 10.1097/00001888-200509000-00007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10219-005&site=ehost-live&scope=site
UR - Colenda@medicine.tamhsc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10916-011
AN - 2005-10916-011
AU - Walsh, J. Michael
AU - Flegel, Ron
AU - Atkins, Randolph
AU - Cangianelli, Leo A.
AU - Cooper, Carnell
AU - Welsh, Christopher
AU - Kerns, Timothy J.
T1 - Drug and alcohol use among drivers admitted to a Level-1 trauma center.
JF - Accident Analysis and Prevention
JO - Accident Analysis and Prevention
JA - Accid Anal Prev
Y1 - 2005/09//
VL - 37
IS - 5
SP - 894
EP - 901
CY - Netherlands
PB - Elsevier Science
SN - 0001-4575
AD - Walsh, J. Michael, Walsh Group, PA, 6701 Democracy Blvd., Suite 300, Bethesda, MD, US, 20817
N1 - Accession Number: 2005-10916-011. PMID: 15927139 Partial author list: First Author & Affiliation: Walsh, J. Michael; Walsh Group, Bethesda, MD, US. Release Date: 20051003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohols; Drivers; Drug Usage; Injuries; Transportation Accidents. Minor Descriptor: Alcohol Drinking Patterns; Motor Vehicles. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2005.
AB - The purpose of this research was to determine the incidence and prevalence of drug use, alcohol use, and the combination of drug and alcohol use among motor vehicle crash (MVC) victims admitted to a Level-1 trauma center. In a 90-day study, nearly two-thirds of trauma center admissions were victims of motor vehicle crashes. Blood and urine was collected from 168 MVC victims of whom 108 were identified as the driver in the crash. Toxicology results indicated that 65.7% of drivers tested positive for either commonly abused drugs or alcohol. More than half of the drivers tested positive for drugs (50.9%) other than alcohol, with one in four drivers testing positive for marijuana use. About one-third of those using drugs had also been drinking, but alcohol was detected in only 30.6% of all injured drivers. Within the total MVC patient pool, passenger drug/alcohol use was equivalent to the driver population; however, injured pedestrians had higher rates of alcohol only than other MVC victims. There were no significant differences in drug and alcohol use between MVCs and trauma admissions of other causes. Of the patients with positive toxicology results, less than half (42%) were referred for evaluation for substance abuse disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug use
KW - alcohol use
KW - motor vehicle crashes
KW - trauma center
KW - injured drivers
KW - 2005
KW - Alcohols
KW - Drivers
KW - Drug Usage
KW - Injuries
KW - Transportation Accidents
KW - Alcohol Drinking Patterns
KW - Motor Vehicles
KW - 2005
DO - 10.1016/j.aap.2005.04.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10916-011&site=ehost-live&scope=site
UR - tkerns@som.umaryland.edu
UR - cwelsh@psych.umaryland.edu
UR - ccooper@umm.edu
UR - leocan@walshgroup.org
UR - randy.atkins@walshgroup.org
UR - rflegel@samhsa.gov
UR - jmwalsh@walshgroup.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-11028-014
AN - 2005-11028-014
AU - Curie, Charles G.
T1 - SAMHSA's Commitment to Eliminating the Use of Seclusion and Restraint.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/09//
VL - 56
IS - 9
SP - 1139
EP - 1140
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Curie, Charles G., 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2005-11028-014. PMID: 16148330 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Curie, Charles G.; Substance Abuse and Mental Health Services Administration, US. Release Date: 20051011. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; Patient Seclusion; Physical Restraint; Professional Organizations; Health Care Administration. Minor Descriptor: Health Care Delivery; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 2. Issue Publication Date: Sep, 2005.
AB - Substance Abuse and Mental Health Services Administration (SAMHSA), believes that the use of seclusion and restraint clouds the vision of a life in the community for everyone and impedes the mission of building resilience and facilitating recovery. This view squares with U.S. Department of Health and Human Services (HHS) Secretary Mike Leavitt's goal, as part of his 500-day plan, of protecting life, family, and human dignity. SAMHSA's leadership role in reducing and eliminating seclusion and restraint begins within the agency itself, where a member of the executive team chairs the cross-cutting initiatives in this area; extends to other departments and agencies within HHS, such as the Centers for Medicare and Medicaid Services; and reaches other federal, national, and state partners in substance abuse, criminal justice, and education. Although the vision may be clear, its realization requires planning. Policy changes are necessary but not sufficient to eliminate the use of seclusion and restraint. Success begins with a change in culture, from one of power to one of empowerment, from coercion to caring, and from hopelessness to hope. Leadership at the top is essential, but, as we learned in Pennsylvania, these changes can't be implemented by fiat--the buy-in of key staff is essential. Indeed, the values of hospital staff and community advocates and their commitment to a nonrestraint philosophy were the major reasons for the changes in attitude, culture, and environment in Pennsylvania's state hospital system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Substance Abuse and Mental Health Services Administration
KW - seclusion
KW - restraint
KW - psychiatric settings
KW - 2005
KW - Mental Health Services
KW - Patient Seclusion
KW - Physical Restraint
KW - Professional Organizations
KW - Health Care Administration
KW - Health Care Delivery
KW - Health Care Policy
KW - 2005
DO - 10.1176/appi.ps.56.9.1139
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11028-014&site=ehost-live&scope=site
UR - charles.curie@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-10098-009
AN - 2005-10098-009
AU - Jiang, H. Joanna
AU - Andrews, Roxanne
AU - Stryer, Daniel
AU - Friedman, Bernard
T1 - Racial/Ethnic Disparities in Potentially Preventable Readmissions: The Case of Diabetes.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2005/09//
VL - 95
IS - 9
SP - 1561
EP - 1567
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Jiang, H. Joanna, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2005-10098-009. PMID: 16118367 Partial author list: First Author & Affiliation: Jiang, H. Joanna; Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20051128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Epidemiology; Hospital Admission; Medicare; Racial and Ethnic Differences. Minor Descriptor: Disease Management. Classification: General Psychology (2100). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2005.
AB - Objectives: Considerable differences in prevalence of diabetes and management of the disease exist among racial/ethnic groups. We examined the relationship between race/ethnicity and hospital readmissions for diabetes-related conditions. Methods: Nonmaternal adult patients with Medicare, Medicaid, or private insurance coverage hospitalized for diabetes-related conditions in 5 states were identified from the 1999 State Inpatient Databases of the Healthcare Cost and Utilization Project. Racial/ethnic differences in the likelihood of readmission were estimated by logistic regression with adjustment for patient demographic, clinical, and socioeconomic characteristics and hospital attributes. Results: The risk-adjusted likelihood of 180-day readmission was significantly lower for non-Hispanic Whites than for Hispanics across all 3 payers or for non-Hispanic Blacks among Medicare enrollees. Within each payer, Hispanics from low-income communities had the highest risk of readmission. Among Medicare beneficiaries, Blacks and Hispanics had higher percentages of readmission for acute complications and microvascular disease, while Whites had higher percentages of readmission for macrovascular conditions. Conclusions: Racial/ethnic disparities are more evident in 180-day than in 30-day readmission rates, and greatest among the Medicare population. Readmission diagnoses vary by race/ethnicity, with Blacks and Hispanics at higher risk for those complications more likely preventable with effective postdischarge care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial ethnic disparities
KW - preventable hospital readmissions
KW - diabetes
KW - disease management
KW - 2005
KW - Diabetes
KW - Epidemiology
KW - Hospital Admission
KW - Medicare
KW - Racial and Ethnic Differences
KW - Disease Management
KW - 2005
DO - 10.2105/AJPH.2004.044222
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-10098-009&site=ehost-live&scope=site
UR - jjiang@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13237-007
AN - 2005-13237-007
AU - Farrell, Phillippa
AU - Travers, Trish
T1 - A healthy start: Mental health promotion in early childhood settings.
JF - AeJAMH (Australian e-Journal for the Advancement of Mental Health)
JO - AeJAMH (Australian e-Journal for the Advancement of Mental Health)
Y1 - 2005/09//
VL - 4
IS - 2
CY - Australia
PB - Auseinet (Australian Network for Promotion, Prevention and Early Intervention for Mental Health)
SN - 1446-7984
AD - Travers, Trish, Mental Health Promotion, Western Australian Country Health Service, Great Southern Public Health Service, PO Box 5147, Albany, WAU, Australia, 6332
N1 - Accession Number: 2005-13237-007. Other Journal Title: Advances in Mental Health. Partial author list: First Author & Affiliation: Farrell, Phillippa; Rockingham Kwinana Child and Adolescent Mental Health Services, Rockingham, WAU, Australia. Other Publishers: Taylor & Francis; eContent Management Pty Ltd. Release Date: 20060403. Correction Date: 20151026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Care Workers; Early Childhood Development; Health Promotion; Mental Health Programs; Primary Mental Health Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: Australia. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. Supplemental Data: Other Appended. References Available: Y. Issue Publication Date: Sep, 2005.
AB - Childcare services are an important part of life for many families. Childcare workers have a vital role in the development of a child's mental health, and yet are often under-trained in this area. This paper describes the implementation, evaluation and sustainability of the Healthy Start program in regional Western Australia, with particular attention to outcomes for childcare workers. Healthy Start aimed to build the capacity of the childcare workforce to promote the mental health of children attending childcare, their families and those working in the childcare sector. A range of strategies was developed and implemented, including mental health literacy training and communication skills training which were delivered to over thirty-five childcare workers. Pre and post-training questionnaires showed that awareness of risk factors, protective factors and referral sources, as well as levels of confidence in discussing mental health issues with parents, increased immediately after training. Baseline and follow-up telephone surveys showed however that the childcare workers' awareness of risk and protective factors was not sustained over a twelve month period. The findings suggested that messages need to be reinforced post-training to retain new knowledge and confidence. As a result, agency partnerships have grown to include a range of early childhood professionals and provide annual training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health promotion
KW - early childhood settings
KW - childcare services
KW - Healthy Start program
KW - childcare workers
KW - 2005
KW - Child Care Workers
KW - Early Childhood Development
KW - Health Promotion
KW - Mental Health Programs
KW - Primary Mental Health Prevention
KW - 2005
DO - 10.5172/jamh.4.2.98
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13237-007&site=ehost-live&scope=site
UR - trish.travers@health.wa.gov.au
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Reepmeyer, John C.
T1 - Analysis of the nitrogen mustard mechlorethamine in topical pharmaceutical preparations by high-performance liquid chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2005/09/02/
VL - 1085
IS - 2
M3 - Article
SP - 262
EP - 269
SN - 00219673
AB - Abstract: Mechlorethamine in topical pharmaceutical formulations was derivatized with benzenethiol to form the disubstitution product and analyzed by normal-phase HPLC on silica gel using dibutyl phthalate as an internal standard. The derivatization reaction, purification, and isolation were conveniently performed in a single test tube. Analyses were successfully performed on three types of ointment formulations: anhydrous hydrophobic petrolatum-based ointments, anhydrous hydrophilic ointments, and hydrous hydrophilic ointments. Precision for the analysis of mechlorethamine standard or mechlorethamine in ointments ranged from 0.08 to 0.52% RSD (n =6). Recoveries from ointments spiked with 0.02% mechlorethamine hydrochloride were 98.4–100.4%. The chromatograms were clean, showing minimal or no interference from ointment excipients or reagents. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Alkylating agents
KW - Nitrogen mustards
KW - Liquid chromatography
KW - Chemical reactions
KW - HPLC
KW - Mechlorethamine
KW - Nitrogen mustard
KW - Ointments
KW - Topical pharmaceutical
N1 - Accession Number: 18151783; Reepmeyer, John C. 1; Email Address: reepmeyerj@cder.fda.gov; Affiliations: 1: U.S. Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA; Issue Info: Sep2005, Vol. 1085 Issue 2, p262; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Alkylating agents; Thesaurus Term: Nitrogen mustards; Thesaurus Term: Liquid chromatography; Subject Term: Chemical reactions; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Mechlorethamine; Author-Supplied Keyword: Nitrogen mustard; Author-Supplied Keyword: Ointments; Author-Supplied Keyword: Topical pharmaceutical; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.chroma.2005.06.057
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gentsch, Jon R.
AU - Laird, Ashley R.
AU - Bielfelt, Brittany
AU - Griffin, Dixie D.
AU - Bányai, Krisztián
AU - Ramachandran, Madhu
AU - Jain, Vivek
AU - Cunliffe, Nigel A.
AU - Nakagomi, Osamu
AU - Kirkwood, Carl D.
AU - Fischer, Thea K.
AU - Parashar, Umesh D.
AU - Bresee, Joseph S.
AU - Jiang, Baoming
AU - Glass, Roger I.
T1 - Serotype Diversity and Reassortment between Human and Animal Rotavirus Strains: Implications for Rotavirus Vaccine Programs.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/09/02/9/1/2005 Supplement
VL - 192
M3 - Article
SP - S146
EP - S159
SN - 00221899
AB - The development of rotavirus vaccines that are based on heterotypic or serotype-specific immunity has prompted many countries to establish programs to assess the disease burden associated with rotavirus infection and the distribution of rotavirus strains. Strain surveillance helps to determine whether the most prevalent local strains are likely to be covered by the serotype antigens found in current vaccines. After introduction of a vaccine, this surveillance could detect which strains might not be covered by the vaccine. Almost 2 decades ago, studies demonstrated that 4 globally common rotavirus serotypes (G1-G4) represent 190% of the rotavirus strains in circulation. Subsequently, these 4 serotypes were used in the development of reassortant vaccines predicated on serotype-specific immunity. More recently, the application of reverse-transcription polymerase chain reaction genotyping, nucleotide sequencing, and antigenic characterization methods has confirmed the importance of the 4 globally common types, but a much greater strain diversity has also been identified (we now recognize strains with at least 42 P-G combinations). These studies also identified globally (G9) or regionally (G5, G8, and P2A[6]) common serotype antigens not covered by the reassortant vaccines that have undergone efficacy trials. The enormous diversity and capacity of human rotaviruses for change suggest that rotavirus vaccines must provide good heterotypic protection to be optimally effective. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases
KW - VIRAL vaccines
KW - VACCINATION
KW - VIRUS diseases
KW - IMMUNIZATION
KW - PREVENTIVE medicine
N1 - Accession Number: 18046845; Gentsch, Jon R. 1; Email Address: jrg4@cdc.gov Laird, Ashley R. 1 Bielfelt, Brittany 1 Griffin, Dixie D. 1 Bányai, Krisztián 2 Ramachandran, Madhu 1 Jain, Vivek 1 Cunliffe, Nigel A. 3 Nakagomi, Osamu 4 Kirkwood, Carl D. 5 Fischer, Thea K. 1 Parashar, Umesh D. 1 Bresee, Joseph S. 1 Jiang, Baoming 1 Glass, Roger I. 1; Affiliation: 1: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary. 3: Department of Medical Microbiology and Genito-Urinary Medicine, University of Liverpool, Liverpool, United Kingdom. 4: Nagasaki University Graduate School of Biomedical Sciences Sakamoto, Nagasaki, Japan. 5: Murdoch Children's Research Institute, Royal Children's Hospital, Victoria, Australia.; Source Info: 9/1/2005 Supplement, Vol. 192, pS146; Subject Term: ROTAVIRUS diseases; Subject Term: VIRAL vaccines; Subject Term: VACCINATION; Subject Term: VIRUS diseases; Subject Term: IMMUNIZATION; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colman, Eric
T1 - Anorectics on Trial: A Half Century of Federal Regulation of Prescription Appetite Suppressants.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2005/09/06/
VL - 143
IS - 5
M3 - Article
SP - 380
EP - 385
SN - 00034819
AB - Beginning with the passage of the Federal Food, Drug, and Cosmetic Act in 1938 and escalating with the 1962 Kefauver-Harris amendments, increasing pressure has been placed on pharmaceutical manufacturers to demonstrate that a drug's benefits outweigh its risks. Nowhere has the question of risk versus benefit come under greater scrutiny than with anorectics. After the approval in the 1940s and 1950s of a number of amphetamine and amphetamine-like compounds for the treatment of obesity, the U.S. Food and Drug Administration struggled to define the efficacy and safety of these agents. Labeling restrictions on duration of use and warnings about abuse and addiction ultimately contributed to the reduced use of anorectics. That trend continued until the mid-1990s, when the off-label use of fenfluramine plus phentermine (fen-phen) and the approval of dexfenfluramine gave rise to wide- spread, long-term use of anorectics to treat obesity. The adverse effects that came to be associated with fenfluramine and dexfenfluramine, leading to their eventual withdrawal from the market, gave pause to regulators, physicians, patients, and drug companies alike. Sibutramine, the latest anorectic to enter the market, is now the focus of a landmark trial that is examining, for the first time, whether drug-induced weight loss reduces the risk for fatal and nonfatal cardiovascular disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG laws & regulations
KW - PHARMACEUTICAL industry
KW - CARDIOVASCULAR diseases
KW - BODY weight
KW - METABOLIC disorders
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 18270101; Colman, Eric 1; Email Address: colmane@cder.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, Maryland.; Source Info: 9/6/2005, Vol. 143 Issue 5, p380; Subject Term: DRUG laws & regulations; Subject Term: PHARMACEUTICAL industry; Subject Term: CARDIOVASCULAR diseases; Subject Term: BODY weight; Subject Term: METABOLIC disorders; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106543417
T1 - History of medicine. Anorectics on trial: a half century of federal regulation of prescription appetite suppressants.
AU - Colman E
Y1 - 2005/09/06/
N1 - Accession Number: 106543417. Language: English. Entry Date: 20051125. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Drug Approval
KW - Appetite Depressants -- History
KW - Obesity -- Drug Therapy
KW - United States Food and Drug Administration -- Legislation and Jurisprudence
SP - 380
EP - 385
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 143
IS - 5
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - Beginning with the passage of the Federal Food, Drug, and Cosmetic Act in 1938 and escalating with the 1962 Kefauver-Harris amendments, increasing pressure has been placed on pharmaceutical manufacturers to demonstrate that a drug's benefits outweigh its risks. Nowhere has the question of risk versus benefit come under greater scrutiny than with anorectics. After the approval in the 1940s and 1950s of a number of amphetamine and amphetamine-like compounds for the treatment of obesity, the U.S. Food and Drug Administration struggled to define the efficacy and safety of these agents. Labeling restrictions on duration of use and warnings about abuse and addiction ultimately contributed to the reduced use of anorectics. That trend continued until the mid-1990s, when the off-label use of fenfluramine plus phentermine (fen-phen) and the approval of dexfenfluramine gave rise to widespread, long-term use of anorectics to treat obesity. The adverse effects that came to be associated with fenfluramine and dexfenfluramine, leading to their eventual withdrawal from the market, gave pause to regulators, physicians, patients, and drug companies alike. Sibutramine, the latest anorectic to enter the market, is now the focus of a landmark trial that is examining, for the first time, whether drug-induced weight loss reduces the risk for fatal and nonfatal cardiovascular disease.
SN - 0003-4819
AD - Division of Metabolic and Endocrine Drug Products, U.S. Food and Drug Administration, HFD-510, 5600 Fishers Lane, Rockville, MD 20857; colman@cder.fda.gov
U2 - PMID: 16144896.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lugo-Villarino, Geanncarlo
AU - Shu-Ichi Ito
AU - Klinman, Dennis M.
AU - Glimcher, Laurie H.
T1 - The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2005/09/13/
VL - 102
IS - 37
M3 - Article
SP - 13248
EP - 13253
SN - 00278424
AB - Treatment with synthetic oligodeoxynucleotides containing CpG motifs (CpG ODNs) is remarkably protective against otherwise lethal infection. Here, we describe an essential role for the transcription factor T-bet in mediating the protective function of CpG ODNs. Loss of T-bet in conventional CD11 chi dendritic cells (DCs) and in plasmacytoid DCs impaired production of IFNs. Strikingly, in contrast to Rag2-/- mice, Rag2-/- mice that also lacked T-bet (DKO) could not be rescued from lethal Listeria monocytogenes infection by prior treatment with CpG ODN. Rescue was achieved by adoptive transfer of CD11 chi DCs from WT, but not T-ber, CpG ODN-treated donor mice. We conclude that T-bet in DCs is required for the adjuvant activity of CpG ODN in infection, revealing its vital role in innate immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENDRITIC cells
KW - IMMUNOLOGICAL adjuvants
KW - LYMPHOID tissue
KW - TRANSCRIPTION factors
KW - LISTERIA monocytogenes
KW - NATURAL immunity
KW - IFN-γ
KW - oligodeoxynucleotide
KW - plasmacytoid dendritic cells
N1 - Accession Number: 18474971; Lugo-Villarino, Geanncarlo 1 Shu-Ichi Ito 2 Klinman, Dennis M. 2 Glimcher, Laurie H. 1,3; Email Address: glimche@hsph.harvard.edu; Affiliation: 1: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017. 2: Department of Medicine, Harvard Medical School, Boston, MA 02115. 3: Division of Therapeutic Proteins, Food and Drug Administration, Building 29A, Room 3B19, 8800 Rockville Pike, Bethesda, MD 20892.; Source Info: 9/13/2005, Vol. 102 Issue 37, p13248; Subject Term: DENDRITIC cells; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: LYMPHOID tissue; Subject Term: TRANSCRIPTION factors; Subject Term: LISTERIA monocytogenes; Subject Term: NATURAL immunity; Author-Supplied Keyword: IFN-γ; Author-Supplied Keyword: oligodeoxynucleotide; Author-Supplied Keyword: plasmacytoid dendritic cells; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0506638102
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Trontell, Anne E.
T1 - The RADAR Project and the FDA.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/09/14/
VL - 294
IS - 10
M3 - Letter
SP - 1206
EP - 1206
SN - 00987484
AB - Presents a letter to the editor about the Research on Adverse Drug Events and Reports (RADAR) study, described by Dr. Bennett and colleagues, and mentions the surveillance efforts of the U.S. Food and Drug Administration.
KW - LETTERS to the editor
KW - DRUGS -- Side effects
KW - Drug Reaction, Adverse
KW - Drug Surveillance, Postmarketing see Product Surveillance, Postmarketing
KW - Product Surveillance, Postmarketing
KW - United States Food and Drug Administration
N1 - Accession Number: 18353194; Trontell, Anne E. 1; Email Address: trontella@cder.fda.gov; Affiliation: 1: Office of Drug Safety, FDA Center for Drug Evaluation and Research, Rockville, Md.; Source Info: 9/14/2005, Vol. 294 Issue 10, p1206; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Side effects; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Drug Surveillance, Postmarketing see Product Surveillance, Postmarketing; Author-Supplied Keyword: Product Surveillance, Postmarketing; Author-Supplied Keyword: United States Food and Drug Administration; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - B'Hymer, Clayton
AU - Butler, Mary Ann
AU - Cheever, Kenneth L.
T1 - Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2005/09/15/
VL - 383
IS - 2
M3 - Article
SP - 201
EP - 209
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Several extraction and derivatization procedures were evaluated for the quantification of (2-methoxyethoxy)acetic acid (MEAA) in urine. MEAA is a metabolite and a biomarker for exposure to 2-(2-methoxyethoxy)ethanol, a glycol ether with widespread use in various industrial applications and the specific use as an anti-icing additive in the military jet fuel formulation JP-8. Quantification of glycol ether biomarkers is an active area of analytical research. Various sample preparation procedures were evaluated: liquid–liquid extraction (LLE) using ethyl acetate yielded the highest recovery, and solid-phase extraction (SPE) gave low recovery of MEAA. Two derivatization procedures were thoroughly investigated and validated, namely, silylation of MEAA with N-methyl- N-( tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), and esterification of MEAA using ethanol. Quantification was performed by gas chromatography (GC) with a mass spectrometer as detector and using a polydimethylsiloxane (HP-1) capillary column. Deuterated 2-butoxyacetic acid (d-BAA) was used as an internal standard. Recovery studies of spiked human urine demonstrated the accuracy and precision of both procedures. The limit of detection (LOD) and other figures of merit for both derivatization procedures will be discussed in detail. Applications of these analysis procedures are also discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETIC acid
KW - URINE
KW - GLYCOLS
KW - ALCOHOL
KW - FATTY acids
KW - 2-(2-methoxyethoxy)ethanol
KW - Alkoxyacetic acids
KW - Glycol ethers
KW - Urinary biomarkers
N1 - Accession Number: 18527379; B'Hymer, Clayton 1; Email Address: cbhymer@cdc.gov Butler, Mary Ann 1 Cheever, Kenneth L. 1; Affiliation: 1: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Sep2005, Vol. 383 Issue 2, p201; Subject Term: ACETIC acid; Subject Term: URINE; Subject Term: GLYCOLS; Subject Term: ALCOHOL; Subject Term: FATTY acids; Author-Supplied Keyword: 2-(2-methoxyethoxy)ethanol; Author-Supplied Keyword: Alkoxyacetic acids; Author-Supplied Keyword: Glycol ethers; Author-Supplied Keyword: Urinary biomarkers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 9p; Illustrations: 2 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00216-005-0048-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106404446
T1 - The metabolic syndrome: early clues, effective management.
AU - Whyte J
Y1 - 2005/09/15/
N1 - Accession Number: 106404446. Language: English. Entry Date: 20060303. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110.
KW - Metabolic Syndrome X -- Diagnosis
KW - Metabolic Syndrome X -- Therapy
KW - Diet
KW - Exercise
KW - Hypercholesterolemia -- Complications
KW - Obesity -- Complications
SP - 1195
EP - 1200
JO - Consultant (00107069)
JF - Consultant (00107069)
JA - CONSULTANT
VL - 45
IS - 11
CY - Framingham, Massachusetts
PB - United Business Media
AB - The principal components of the metabolic syndrome are abdominal obesity, elevated levels of triglycerides, low levels of high-density lipoprotein cholesterol, hypertension, and an elevated fasting glucose level. Early diagnosis and aggressive treatment may reduce the elevated risk of diabetes and cardiovascular disease associated with the syndrome. Lifestyle modification is the cornerstone of therapy. Weight loss ameliorates all facets of the metabolic syndrome. Exercise contributes to weight loss, reduced blood pressure, improved lipid pro-files, and reduced insulin resistance. Pharmacotherapy or surgery may be options for obese patients in whom lifestyle intervention is unsuccessful. Consider statin therapy for patients in whom dyslipidemia cannot be controlled by lifestyle intervention alone.
SN - 0010-7069
AD - (Former) Medical Advisor, US Department of Health and Human Services, Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wells, J. R.
T1 - Gas-Phase Chemistry of &-Terpineol with Ozone and OH Radical: Rate Constants and Products.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2005/09/15/
VL - 39
IS - 18
M3 - Article
SP - 6937
EP - 6943
SN - 0013936X
AB - A bimolecular rate constant, kOH+αterpineol, of (1.9 ± 0.5) × 10-10 cm3 molecule-1 r-1 was measured using gas chromatography/mass spectrometry and the relative rate technique for the reaction of the hydroxyl radical (OH) with α-terpineol (1-methyl-4-isopropyl-1-cyclohexen-8-ol) at (297 ± 3) K and 1 atm total pressure. Additionally, a bimolecular rate constant kO3+α-terpineol, of (3.0 ± 0.2) × 10-16 cm3 molecule-1 S-1 was measured by monitoring the first order decrease in ozone concentration as a function of excess α-terpineol. To better understand α-terpineol's gas-phase transformation in the indoor environment, the products of the α-terpineol + OH and α-terpineol +O3 reactions were also investigated. The positively identified α-terpineol/OH reaction products were acetone, ethanedial (glyoxal, HC(=O)C(=O)H), and 2-oxopropanal (methyl glyoxal, CH3C(=O)C(=O)H). The positively identified α-terpineol/O3 reaction product was 2-oxopropanal (methyl glyoxal, CH3C(=O)C(=O)H). The use of derivatizing agents O-(2,3,4,5,6-pentalfluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) clearly indicated that several other reaction products were formed. The elucidation of these other reaction products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible α-terpineol/OH and α-terpineol/O3 reaction mechanisms based on previously published volatile organic compound/ OH and volatile organic compound/O3 gas-phase reaction mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gas chromatography
KW - Mass spectrometry
KW - Spectrum analysis
KW - Pressure
KW - Hydroxyl group
KW - Nuclear spectroscopy
N1 - Accession Number: 18366538; Wells, J. R. 1; Email Address: ozw0@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgan town, West Virginia 26505.; Issue Info: 9/15/2005, Vol. 39 Issue 18, p6937; Thesaurus Term: Gas chromatography; Thesaurus Term: Mass spectrometry; Thesaurus Term: Spectrum analysis; Thesaurus Term: Pressure; Subject Term: Hydroxyl group; Subject Term: Nuclear spectroscopy; Number of Pages: 7p; Document Type: Article
L3 - 10.1021/es0481676
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wang, Weila
AU - Golding, Basil
T1 - The cytotoxic T lymphocyte response against a protein antigen does not decrease the antibody response to that antigen although antigen-pulsed B cells can be targets
JO - Immunology Letters
JF - Immunology Letters
Y1 - 2005/09/15/
VL - 100
IS - 2
M3 - Article
SP - 195
EP - 201
SN - 01652478
AB - Abstract: The role of activated CD8+ T cells in shaping the dynamics of in vivo antigen presentation and immune responses is a subject receiving more attention. We studied whether cytotoxic T lymphocyte (CTL) would limit antibody responses by targeting antigen-specific B cells. A modified in vivo CTL assay was developed and used herein to demonstrate cytotoxicity in vivo, and to show that antigen-specific B cells that process exogenous antigen and present peptide in association with MHC class I can be the targets of CD8+ T cells. B cells from C57BL/6 mice immunized with ovalbumin (OVA)/alum were pulsed with OVA in vitro, and transferred into C57BL/6 recipient mice that had been immunized with vaccinia virus expressing SIINFEKL minigene to generate CD8+ CTL against Kb/SIINFEKL. OVA-pulsed B220+ B cells from OVA-immunized mice were killed to a greater extent than B220+ B cells from naïve mice (28±20% versus 12±16%, p =0.0042). However, mice receiving vaccinia-SIINFEKL and generating CTL, did not appear to target endogenous B cells, since both primary and secondary antibody responses to OVA were unaffected. Our findings indicate that CTL responses to the protein antigen do not interfere with endogenous B cell responses, even though exogenous B cells expressing the CTL epitope can be efficiently lysed. [Copyright &y& Elsevier]
AB - Copyright of Immunology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - LEUCOCYTES
KW - LIVER diseases
KW - HEPATITIS B virus
KW - Antibody response
KW - Antigen-specific B cells
KW - CTL
KW - cytotoxic T lymphocyte ( CTL )
KW - hepatitis B virus ( HBV )
KW - lymphocytic choriomeningitis virus ( LCMV )
KW - MHC class I presentation
KW - ovalbumin ( OVA )
KW - Vaccine
KW - vaccinia virus
KW - vv
N1 - Accession Number: 18282993; Wang, Weila; Email Address: wangw@cber.fda.gov Golding, Basil 1; Affiliation: 1: Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA; Source Info: Sep2005, Vol. 100 Issue 2, p195; Subject Term: LYMPHOCYTES; Subject Term: LEUCOCYTES; Subject Term: LIVER diseases; Subject Term: HEPATITIS B virus; Author-Supplied Keyword: Antibody response; Author-Supplied Keyword: Antigen-specific B cells; Author-Supplied Keyword: CTL; Author-Supplied Keyword: cytotoxic T lymphocyte ( CTL ); Author-Supplied Keyword: hepatitis B virus ( HBV ); Author-Supplied Keyword: lymphocytic choriomeningitis virus ( LCMV ); Author-Supplied Keyword: MHC class I presentation; Author-Supplied Keyword: ovalbumin ( OVA ); Author-Supplied Keyword: Vaccine; Author-Supplied Keyword: vaccinia virus; Author-Supplied Keyword: vv; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.imlet.2005.04.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porwollik, S.
AU - Santiviago, C. A.
AU - Cheng, P.
AU - Florea, L.
AU - Jackson, S.
AU - McClelland, M.
T1 - Differences in Gene Content between Salmonella enterica Serovar Enteritidis Isolates and Comparison to Closely Related Serovars Gallinarum and Dublin.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2005/09/15/
VL - 187
IS - 18
M3 - Article
SP - 6545
EP - 6555
SN - 00219193
AB - Salmonella enterica serovar Enteritidis is often transmitted into the human food supply through eggs of hens that appear healthy. This pathogen became far more prevalent in poultry following eradication of the fowl pathogen S. enterica serovar Gallinarum in the mid-20th century. To investigate whether changes in serovar Enteritidis gene content contributed to this increased prevalence, and to evaluate genetic heterogeneity within the serovar, comparative genomic hybridization was performed on eight 60-year-old and nineteen 10- to 20-year-old serovar Enteritidis strains from various hosts, using a Salmonella-specific microarray. Overall, almost all the serovar Enteritidis genomes were very similar to each other. Excluding two rare strains classified as serovar Enteritidis in the Salmonella reference collection B, only eleven regions of the serovar Enteritidis phage type 4 (PT4) chromosome (sequenced at the Sanger Center) were absent or divergent in any of the other serovar Enteritidis strains tested. The more recent isolates did not have consistent differences from 60-year-old field isolates, suggesting that no large genomic additions on a whole-gene scale were needed for serovar Enteritidis to become more prevalent in domestic fowl. Cross-hybridization of phage genes on the array with related genes in the examined genomes grouped the serovar Enteritidis isolates into two major lineages. Microarray comparisons of the sequenced serovar Enteritidis PT4 to isolates of the closely related serovars Dublin and Gallinarum (biovars Gallinarum and Pullorum) revealed several genomic areas that distinguished them from serovar Enteritidis and from each other. These differences in gene content could be useful in DNA-based typing and in understanding the different phenotypes of these related serovars. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - SALMONELLA
KW - PATHOGENIC microorganisms
KW - POULTRY
KW - HYBRIDIZATION
KW - GENOMES
KW - DNA
N1 - Accession Number: 18418214; Porwollik, S. 1 Santiviago, C. A. 1 Cheng, P. 1 Florea, L. 2 Jackson, S. 3 McClelland, M. 1; Email Address: mmcclelland@skcc.org; Affiliation: 1: Sidney Kimmel Cancer Center, 10835 Road to the Cure, San Diego, California 92121 2: George Washington University, 801 22nd Street NW, Suite 704, Washington, DC 20052 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Rd., Laurel, Maryland 20708; Source Info: Sep2005, Vol. 187 Issue 18, p6545; Subject Term: SALMONELLA enteritidis; Subject Term: SALMONELLA; Subject Term: PATHOGENIC microorganisms; Subject Term: POULTRY; Subject Term: HYBRIDIZATION; Subject Term: GENOMES; Subject Term: DNA; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 445210 Meat Markets; Number of Pages: 11p; Illustrations: 1 Color Photograph, 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1128/JB.187.18.6545-6555.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Okamura, Masashi
AU - Lillehoj, Hyun S.
AU - Raybourne, Richard B.
AU - Babu, Uma S.
AU - Heckert, Robert A.
AU - Tani, Hiroyuki
AU - Sasai, Kazumi
AU - Baba, Eiichiroh
AU - Lillehoj, Erik P.
T1 - Differential responses of macrophages to Salmonella enterica serovars Enteritidis and Typhimurium
JO - Veterinary Immunology & Immunopathology
JF - Veterinary Immunology & Immunopathology
Y1 - 2005/09/15/
VL - 107
IS - 3/4
M3 - Article
SP - 327
EP - 335
SN - 01652427
AB - Abstract: Macrophages are major effectors against Salmonella infection, and also transport bacteria between host tissues and provide a protected site for intracellular bacterial replication. We hypothesized that differences in chicken macrophage responses to Salmonella enterica serovar Enteritidis (SE) and serovar Typhimurium (ST) played a role in preferential infection of eggs by SE compared with ST. To test this hypothesis, we determined bacterial phagocytosis and intracellular viability and macrophage nitric oxide (NO) production following in vitro infection with SE or ST in the presence or absence of interferon-γ (IFN-γ). The effects of bacterial components, lipopolysaccharide (LPS), outer membrane proteins (OMP) and flagella, on NO production were also assessed. Our results showed: (1) in the presence or absence of IFN-γ, the percentage macrophages phagocytizing SE and ST was similar; (2) the number of intracellular viable SE was significantly reduced compared with ST in the presence or absence of IFN-γ; (3) increased macrophage necrosis was seen in the presence of IFN-γ and ST; (4) Salmonella infection acted synergistically with IFN-γ in induction of nitric oxide production; and (5) in the absence of IFN-γ, macrophages produced significantly greater NO following treatment with SE outer membrane protein or flagella compared with ST OMP or flagella, while in the presence of IFN-γ significantly less NO was produced following treatment with SE-LPS compared with ST-LPS. These results suggest that differential responses of chicken macrophages to SE versus ST may result in increased macrophage death with ST, which could result in an increased inflammatory response as compared to SE. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Immunology & Immunopathology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - ANTIGEN presenting cells
KW - CONNECTIVE tissue cells
KW - KILLER cells
KW - Chicken
KW - Egg
KW - Food poisoning
KW - green fluorescent protein ( GFP )
KW - Interferon-γ
KW - interferon-γ ( IFN-γ )
KW - Nitric oxide
KW - nitric oxide ( NO )
KW - outer membrane protein ( OMP )
KW - Salmonella enterica serovar Enteritidis ( SE )
KW - Salmonella enterica serovar Typhimurium ( ST )
N1 - Accession Number: 18150841; Okamura, Masashi 1 Lillehoj, Hyun S. 1; Email Address: hlilleho@anri.barc.usda.gov Raybourne, Richard B. 2 Babu, Uma S. 2 Heckert, Robert A. 3 Tani, Hiroyuki 4 Sasai, Kazumi 4 Baba, Eiichiroh 4 Lillehoj, Erik P. 5; Affiliation: 1: Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, US Department of Agriculture, Bldg 1040 BARC-East Beltsville, MD 20705, USA 2: Immunobiology Branch, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA 3: Avrum Gudelsky Veterinary Center, University of Maryland, College Park, MD 20742, USA 4: Department of Veterinary Internal Medicine, Division of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan 5: Department of Pediatrics, University of Maryland, School of Medicine, Baltimore, MD 21201, USA; Source Info: Sep2005, Vol. 107 Issue 3/4, p327; Subject Term: MACROPHAGES; Subject Term: ANTIGEN presenting cells; Subject Term: CONNECTIVE tissue cells; Subject Term: KILLER cells; Author-Supplied Keyword: Chicken; Author-Supplied Keyword: Egg; Author-Supplied Keyword: Food poisoning; Author-Supplied Keyword: green fluorescent protein ( GFP ); Author-Supplied Keyword: Interferon-γ; Author-Supplied Keyword: interferon-γ ( IFN-γ ); Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: nitric oxide ( NO ); Author-Supplied Keyword: outer membrane protein ( OMP ); Author-Supplied Keyword: Salmonella enterica serovar Enteritidis ( SE ); Author-Supplied Keyword: Salmonella enterica serovar Typhimurium ( ST ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vetimm.2005.05.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ellenberger, Dennis
AU - Wyatt, Linda
AU - Li, Bin
AU - Buge, Suzan
AU - Lanier, Nattawan
AU - Rodriguez, I. Vanesssa
AU - Sariol, Carlos A.
AU - Martinez, Melween
AU - Monsour, Michael
AU - Vogt, Jennifer
AU - Smith, James
AU - Otten, Ronald
AU - Montefiori, David
AU - Kraiselburd, Edmundo
AU - Moss, Bernard
AU - Robinson, Harriet
AU - McNicholl, Janet
AU - Butera, Salvatore
T1 - Comparative immunogenicity in rhesus monkeys of multi-protein HIV-1 (CRF02_AG) DNA/MVA vaccines expressing mature and immature VLPs.
JO - Virology
JF - Virology
Y1 - 2005/09/15/
VL - 340
IS - 1
M3 - Article
SP - 21
EP - 32
SN - 00426822
AB - Abstract: We developed an AIDS vaccine for Western and West-Central Africa founded on HIV-1 subtype CRF02_AG. Rhesus macaques were primed with Gag–Pol–Env-expressing plasmid DNA and boosted with a recombinant modified vaccinia virus Ankara (rMVA), expressing matched proteins. Two DNA vaccine constructs (IC1–90 and IC48) that differed by point mutations in gag and pol were compared. IC1–90 produces primarily immature (core comprises unprocessed Pr55Gag) HIV-like particles (VLPs) and IC48 produces mature VLP with processed Pr55Gag, immature VLP, and intracellular protein aggregates. Both vaccines raised significant cellular responses for Gag, Pol, and Env. Approximate twofold higher ELISPOT responses to Gag and Env epitopes were observed for IC48 animals than for IC1–90 animals at the peak post-MVA effector (P = 0.028) and late memory (P = 0.051) phases, respectively. Greater breadth for IC48-primed animals was observed than for IC1–90-primed animals at peak response (P = 0.03). Our results indicated that the vaccines elicited high frequency T cell responses and primed anti-Env antibody. They also suggest that expression of different forms of VLP has a significant effect on elicited cellular and humoral immunity. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHESUS monkey
KW - HIV (Viruses)
KW - DNA
KW - AIDS (Disease)
KW - CRF02_AG
KW - CRF02_AG
KW - Immunogenicity
KW - Rhesus monkeys
N1 - Accession Number: 18241788; Ellenberger, Dennis 1; Email Address: dellenberger@cdc.gov Wyatt, Linda 2 Li, Bin 1 Buge, Suzan 1 Lanier, Nattawan 1 Rodriguez, I. Vanesssa 3 Sariol, Carlos A. 4 Martinez, Melween 3 Monsour, Michael 5 Vogt, Jennifer 2 Smith, James 6 Otten, Ronald 1 Montefiori, David 7 Kraiselburd, Edmundo 4 Moss, Bernard 2 Robinson, Harriet 6 McNicholl, Janet 1 Butera, Salvatore 1; Affiliation: 1: Laboratory Branch, Centers for Disease Control and Prevention, Mail Stop G-19, 1600 Clifton Road NE, Atlanta, GA 30333, USA 2: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 3: Unit of Comparative Medicine, Caribbean Primate Research Center, San Juan 00936, Puerto Rico 4: Department of Microbiology and Medical Zoology, Caribbean Primate Research Center, San Juan 00936, Puerto Rico 5: Statistics and Data Management Branch, Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA 6: Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA 7: Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA; Source Info: Sep2005, Vol. 340 Issue 1, p21; Subject Term: RHESUS monkey; Subject Term: HIV (Viruses); Subject Term: DNA; Subject Term: AIDS (Disease); Author-Supplied Keyword: CRF02_AG; Author-Supplied Keyword: CRF02_AG; Author-Supplied Keyword: Immunogenicity; Author-Supplied Keyword: Rhesus monkeys; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.virol.2005.06.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Qi Chen
AU - Espey, Michael Graham
AU - Krishna, Murali C.
AU - Mitchell, James B.
AU - Corpe, Christopher P.
AU - Buettner, Garry R.
AU - Shacter, Emily
AU - Levine, Mark
T1 - Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2005/09/20/
VL - 102
IS - 38
M3 - Article
SP - 13604
EP - 13609
SN - 00278424
AB - Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether ascorbate killed cancer cells selectively, and if so, to determine mechanisms, using clinically relevant conditions. Cell death in 10 cancer and 4 normal cell types was measured by using 1-h exposures. Normal cells were unaffected by 20 mM ascorbate, whereas 5 cancer lines had EC50 values of <4 mM, a concentration easily achievable iv. Human lymphoma cells were studied in detail because of their sensitivity to ascorbate (EC50 of 0.5 mM) and suitability for addressing mechanisms. Extracellular but not intra- cellular ascorbate mediated cell death, which occurred by apoptosis and pyknosis/necrosis. Cell death was independent of metal chelators and absolutely dependent on H2O2 formation. Cell death from H2O2 added to cells was identical to that found when H2O2 was generated by ascorbate treatment. H2O2 generation was dependent on ascorbate concentration, incubation time, and the presence of 0.5-10% serum, and displayed a linear relationship with ascorbate radical formation. Although ascorbate addition to medium generated H2O2, ascorbate addition to blood generated no detectable H2O2 and only trace detectable ascorbate radical. Taken together, these data indicate that ascorbate at concentrations achieved only by i.v. administration may be a prodrug for formation of H2O2, and that blood can be a delivery system of the pro-drug to tissues. These findings give plausibility to i.v. ascorbic acid in cancer treatment, and have unexpected implications for treatment of infections where H2O2 may be beneficial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - VITAMIN C
KW - PHARMACOKINETICS
KW - CELL death
KW - CANCER cells
KW - DRUG metabolism
KW - APOPTOSIS
KW - ascorbate radical
KW - cell death
N1 - Accession Number: 18520512; Qi Chen 1,2 Espey, Michael Graham 3 Krishna, Murali C. 3 Mitchell, James B. 3 Corpe, Christopher P. 1 Buettner, Garry R. 4 Shacter, Emily 2 Levine, Mark 1; Email Address: markl@mail.nih.gov; Affiliation: 1: Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892. 2: Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. 3: Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. 4: Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242-1101.; Source Info: 9/20/2005, Vol. 102 Issue 38, p13604; Subject Term: CANCER treatment; Subject Term: VITAMIN C; Subject Term: PHARMACOKINETICS; Subject Term: CELL death; Subject Term: CANCER cells; Subject Term: DRUG metabolism; Subject Term: APOPTOSIS; Author-Supplied Keyword: ascorbate radical; Author-Supplied Keyword: cell death; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0506390102
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Snyder
AU - J. A.
T1 - Carboxylate Binding to Be2+ in Proteins and Influence of the Dielectric Environment.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2005/09/22/
VL - 109
IS - 37
M3 - Article
SP - 17757
EP - 17761
SN - 15206106
AB - To gain insight into the interaction of Be2+ ions with negatively charged protein residues, the free energy changes associated with the replacement of water molecules in the first hydration shell of [inline equation] with one and two acetate anions were computed for the gas phase reactions using ab initio methods at the MP2 and DFT-B3LYP computational levels. Both unidentate and bidentate modes of coordination of the carboxylate group with the Be2+ ion are considered. Continuum dielectric calculations were then performed to estimate the corresponding free energy changes in several environments of varying dielectric strength. Environments with dielectric constants of 2 and 4, which represent a protein interior, and 78, which corresponds to water, were used. It is found that the free energy changes for the substitution reactions decrease in magnitude with increasing dielectric strength, in agreement with similar results reported for Mg2+, Ca2+, and Zn2+ (Dudev et al. J. Phys. Chem. B 2000, 104, 3692). However, unlike Mg2+, Ca2+, and Zn2+, the free energy change for single-anion or concerted two-anion substitution reactions with [inline equation] remains negative and indicates the reactions are still favorable in the high dielectric aqueous environment. It is also found that the unidentate mode of binding is favored over the bidentate mode, and this is attributed, in part, to the introduction of hydrogen bonds between one carboxylate oxygen and a water molecule within the cluster when unidentate binding with Be2+ is involved. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERMEDIATES (Chemistry)
KW - CHEMICAL reactions
KW - SOLUTION (Chemistry)
KW - PHOTOSYNTHETIC oxygen evolution
N1 - Accession Number: 20705032; Snyder J. A. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505-2888; Source Info: Sep2005, Vol. 109 Issue 37, p17757; Subject Term: INTERMEDIATES (Chemistry); Subject Term: CHEMICAL reactions; Subject Term: SOLUTION (Chemistry); Subject Term: PHOTOSYNTHETIC oxygen evolution; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rotblatt, H.
AU - Montoya, J.
AU - Kerndt, P. R.
AU - Kim-Farley, R.
AU - Fielding, J.
AU - Bustamante, T.
AU - Bernard, B.
AU - Brooks, J. T.
AU - Kalish, M.
AU - Robbins, K.
AU - Kenney, K
AU - Laubacher, L.
AU - Taylor, M.
AU - Daar, E.
T1 - HIV Transmission in the Adult Film Industry -- Los Angeles, California, 2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2005/09/23/
VL - 54
IS - 37
M3 - Article
SP - 923
EP - 926
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Summarizes an investigation into HIV transmission cases among adult film industry workers in Los Angeles, California in 2004. Use of nucleic acid testing method for testing film industry workers; Background on the sex-related activities of the workers.
KW - AIDS (Disease) -- Transmission
KW - HIV-positive persons
KW - SEXUALLY transmitted diseases
KW - MOTION picture industry
KW - LOS Angeles (Calif.)
KW - CALIFORNIA
N1 - Accession Number: 18419958; Rotblatt, H. 1 Montoya, J. 1 Kerndt, P. R. 1 Kim-Farley, R. 1 Fielding, J. 1 Bustamante, T. 2 Bernard, B. 3 Brooks, J. T. 4 Kalish, M. 4 Robbins, K. 4 Kenney, K 5 Laubacher, L. 5 Taylor, M. 5 Daar, E. 6; Affiliation: 1: Los Angeles Dept of Public Health 2: California Dept of Health Svcs. 3: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health 4: Div of HIV/AIDS Prevention 5: Div of STD Prevention, National Center for HIV, STD, and TB Prevention, CDC 6: Harbor-UCLA Medical Center, Torrance; Source Info: 9/23/2005, Vol. 54 Issue 37, p923; Subject Term: AIDS (Disease) -- Transmission; Subject Term: HIV-positive persons; Subject Term: SEXUALLY transmitted diseases; Subject Term: MOTION picture industry; Subject Term: LOS Angeles (Calif.); Subject Term: CALIFORNIA; NAICS/Industry Codes: 512199 Other Motion Picture and Video Industries; NAICS/Industry Codes: 512130 Motion picture and video exhibition; NAICS/Industry Codes: 512110 Motion Picture and Video Production; NAICS/Industry Codes: 512120 Motion Picture and Video Distribution; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warny, Michel
AU - Pepin, Jacques
AU - Fang, Aiqi
AU - Killgore, George
AU - Thompson, Angela
AU - Brazier, Jon
AU - Frost, Eric
AU - McDonald, L. Clifford
T1 - Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.
JO - Lancet
JF - Lancet
Y1 - 2005/09/24/
VL - 366
IS - 9491
M3 - Article
SP - 1079
EP - 1084
PB - Lancet
SN - 00995355
AB - Summary Background Toxins A and B are the primary virulence factors of Clostridium difficile. Since 2002, an epidemic of C difficile-associated disease with increased morbidity and mortality has been present in Quebec province, Canada. We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains. Methods We obtained isolates from 124 patients from Centre Hospitalier Universitaire de Sherbrooke in Quebec. Additional isolates from the USA, Canada, and the UK were included to increase the genetic diversity of the toxinotypes tested. Isolate characterization included toxinotyping, pulsed-field gel electrophoresis (PFGE), PCR ribotyping, detection of a binary toxin gene, and detection of deletions in a putative negative regulator for toxins A and B (tcdC). By use of an enzyme-linked immunoassay, we measured the in-vitro production of toxins A and B by epidemic strain and non-dominant strain isolates. Findings The epidemic strain was characterized as toxinotype III, North American PFGE type 1, and PCR-ribotype 027 (NAP1/027). This strain carried the binary toxin gene cdtB and an 18-bp deletion in tcdC. We isolated this strain from 72 patients with C difficile-associated disease (58 [67%] of 86 with health-care-associated disease; 14 [37%] of 38 with community-acquired disease). Peak median (IQR) toxin A and toxin B concentrations produced in vitro by NAP1/027 were 16 and 23 times higher, respectively, than those measured in isolates representing 12 different PFGE types, known as toxinotype 0 (toxin A, median 848 μg/L [IQR 504-1022] vs 54 μg/L [23-203]; toxin B, 180 μg/L [137-210] vs 8 μg/L [5-25]; p<0·0001 for both toxins). Interpretation The severity of C difficile-associated disease caused by NAP1/027 could result from hyperproduction of toxins A and B. Dissemination of this strain in North America and Europe could lead to important changes in the epidemiology of C difficile-associated disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM difficile
KW - EPIDEMICS
KW - TOXINS
KW - EPIDEMIOLOGY
KW - COMMUNICABLE diseases
KW - PUBLIC health
KW - QUEBEC (Province)
KW - CANADA
N1 - Accession Number: 18335487; Warny, Michel 1; Email Address: michel.warny@acambis.com Pepin, Jacques 2 Fang, Aiqi 1 Killgore, George 3 Thompson, Angela 3 Brazier, Jon 4 Frost, Eric 2 McDonald, L. Clifford 3; Affiliation: 1: Acambis Inc, Cambridge, MA, USA 2: University of Sherbrooke, Sherbrooke, Quebec, Canada 3: Centers for Disease Control and Prevention, Atlanta, GA, USA 4: Anaerobe Reference Laboratory, National Public Health Service for Wales, Microbiology Cardiff University Hospital of Wales, Cardiff, UK; Source Info: 9/24/2005, Vol. 366 Issue 9491, p1079; Subject Term: CLOSTRIDIUM difficile; Subject Term: EPIDEMICS; Subject Term: TOXINS; Subject Term: EPIDEMIOLOGY; Subject Term: COMMUNICABLE diseases; Subject Term: PUBLIC health; Subject Term: QUEBEC (Province); Subject Term: CANADA; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/S0140-6736(05)67420-X
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Seung-Hyun
AU - Seo, Sung-Chul
AU - Schmechel, Detlef
AU - Grinshpun, Sergey A.
AU - Reponen, Tiina
T1 - Aerodynamic characteristics and respiratory deposition of fungal fragments
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2005/09/30/
VL - 39
IS - 30
M3 - Article
SP - 5454
EP - 5465
SN - 13522310
AB - Abstract: The purpose of this study was to investigate the aerodynamic characteristics of fungal fragments and to estimate their respiratory deposition. Fragments and spores of three different fungal species (Aspergillus versicolor, Penicillium melinii, and Stachybotrys chartarum) were aerosolized by the fungal spore source strength tester (FSSST). An electrical low-pressure impactor (ELPI) measured the size distribution in real-time and collected the aerosolized fungal particles simultaneously onto 12 impactor stages in the size range of 0.3–10μm utilizing water-soluble ZEF-X10 coating of the impaction stages to prevent spore bounce. For S. chartarum, the average concentration of released fungal fragments was 380particlescm−3, which was about 514 times higher than that of spores. A. versicolor was found to release comparable amount of spores and fragments. Microscopic analysis confirmed that S. chartarum and A. versicolor did not show any significant spore bounce, whereas the size distribution of P. melinii fragments was masked by spore bounce. Respiratory deposition was calculated using a computer-based model, LUDEP 2.07, for an adult male and a 3-month-old infant utilizing the database on the concentration and size distribution of S. chartarum and A. versicolor aerosols measured by the ELPI. Total deposition fractions for fragments and spores were 27–46% and 84–95%, respectively, showing slightly higher values in an infant than in an adult. For S. chartarum, fragments demonstrated 230–250 fold higher respiratory deposition than spores, while the number of deposited fragments and spores of A. versicolor were comparable. It was revealed that the deposition ratio (the number of deposited fragments divided by that of deposited spores) in the lower airways for an infant was 4–5 times higher than that for an adult. As fungal fragments have been shown to contain mycotoxins and antigens, further exposure assessment should include the measurement of fungal fragments for evaluating mold exposures in damp buildings. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOACTIVE source strength
KW - MYCOTOXICOSES
KW - POISONING
KW - MYCOTOXINS
KW - Electrical low-pressure impactor
KW - Exposure
KW - Fragment
KW - Mold
KW - Spore
N1 - Accession Number: 18296179; Cho, Seung-Hyun 1 Seo, Sung-Chul 1 Schmechel, Detlef 2 Grinshpun, Sergey A. 1 Reponen, Tiina 1; Email Address: tiina.reponen@uc.edu; Affiliation: 1: Center for Health-Related Aerosol Studies, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA 2: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2845, USA; Source Info: Sep2005, Vol. 39 Issue 30, p5454; Subject Term: RADIOACTIVE source strength; Subject Term: MYCOTOXICOSES; Subject Term: POISONING; Subject Term: MYCOTOXINS; Author-Supplied Keyword: Electrical low-pressure impactor; Author-Supplied Keyword: Exposure; Author-Supplied Keyword: Fragment; Author-Supplied Keyword: Mold; Author-Supplied Keyword: Spore; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.atmosenv.2005.05.042
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andresen, Penny Rechkemmer
AU - Ramachandran, Gurumurthy
AU - Pai, Pramod
AU - Maynard, Andrew
T1 - Women's personal and indoor exposures to PM2.5 in Mysore, India: Impact of domestic fuel usage
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2005/09/30/
VL - 39
IS - 30
M3 - Article
SP - 5500
EP - 5508
SN - 13522310
AB - Abstract: In traditional societies, women are more likely to be adversely affected by exposures to fine particulates from domestic fuel combustion due to their role in the family as the primary cooks. In this study, 24-h gravimetric personal and indoor PM2.5 exposures were measured for 15 women using kerosene and another 15 women using liquefied petroleum gas (LPG) as their main cooking fuel in Mysore, India. The women also answered a detailed questionnaire regarding their residential housing characteristics, health status, cooking practices and socioeconomic status. Repeated measurements were obtained during two seasons. The main objective of this study was to determine whether exposures to PM2.5 differed according to fuel usage patterns. A repeated-measures general linear model (GLM) was used to analyze the data. Women using kerosene as their primary cooking fuel had significantly higher exposures. During summer, the arithmetic mean (± standard error) for kerosene users personal exposure was 111±13 and 71±15μgm−3 for LPG users. Kerosene users had higher exposures in winter (177±21μgm−3) compared to summer exposures. However, for LPG users there was no difference in their seasonal geometric mean exposures at 71±13μgm−3. Indoor concentrations followed similar patterns. In summer, kerosene-using households had an arithmetic mean concentration of 98±9μgm−3 and LPG-using households had an arithmetic mean concentration of 71±9μgm−3. Winter concentrations were significantly higher than summer concentrations for kerosene users (155±13μgm−3). Again, LPG users showed only slightly higher indoor concentrations (73±6μgm−3) than kerosene users. Socioeconomic status, age, season and income were significant predictors of cooking fuel choice. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR pollution standards
KW - KEROSENE
KW - PETROLEUM products
KW - MATHEMATICS
KW - Cooking fuels
KW - Domestic fuel combustion
KW - Exposure assessment
KW - Indoor air pollution
KW - PM2.5
KW - Women's exposures
N1 - Accession Number: 18296184; Andresen, Penny Rechkemmer 1; Email Address: pandrese@jhsph.edu Ramachandran, Gurumurthy 1 Pai, Pramod 2 Maynard, Andrew 3; Affiliation: 1: Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware St. SE, Minneapolis, MN 55455, USA 2: Department of Environmental Sciences, University of Mysore, Mysore-570 006, India 3: National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, OH, USA; Source Info: Sep2005, Vol. 39 Issue 30, p5500; Subject Term: AIR pollution standards; Subject Term: KEROSENE; Subject Term: PETROLEUM products; Subject Term: MATHEMATICS; Author-Supplied Keyword: Cooking fuels; Author-Supplied Keyword: Domestic fuel combustion; Author-Supplied Keyword: Exposure assessment; Author-Supplied Keyword: Indoor air pollution; Author-Supplied Keyword: PM2.5; Author-Supplied Keyword: Women's exposures; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 486910 Pipeline Transportation of Refined Petroleum Products; NAICS/Industry Codes: 424720 Petroleum and Petroleum Products Merchant Wholesalers (except Bulk Stations and Terminals); NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.atmosenv.2005.06.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levitin, Fiana
AU - Stern, Omer
AU - Weiss, Mordechai
AU - Gil-Henn, Chava
AU - Ziv, Ravit
AU - Prokocimer, Zofnat
AU - Smorodinsky, Nechama I.
AU - Rubinstein, Daniel B.
AU - Wreschner, Daniel H.
T1 - The MUC1 SEA Module Is a Self-cleaving Domain.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/09/30/
VL - 280
IS - 39
M3 - Article
SP - 33374
EP - 33386
SN - 00219258
AB - MUC1, a glycoprotein overexpressed by a variety of human adenocarcinomas, is a type I transmembrane protein (MUC1/TM) that soon after its synthesis undergoes proteolytic cleavage in its extracellular domain. This cleavage generates two subunits, α and β, that specifically recognize each other and bind together in a strong non-covalent interaction. Proteolysis occurs within the SEA module, a 120-amino acid domain that is highly conserved in a number of heavily glycosylated mucin-like proteins. Post-translational cleavage of the SEA module occurs at a site similar to that in MUC1 in the glycoproteins IgHepta and MUC3. However, as in the case of other proteins containing the cleaved SEA module, the mechanism of MUC1 proteolysis has not been elucidated. Alternative splicing generates two transmembrane MUC1 isoforms, designated MUC1/Y and MUC1/X. We demonstrated here that MUC1/X, whose extracellular domain is comprised solely of the SEA module in addition to 30 MUC1 N-terminal amino acids, undergoes proteolytic cleavage at the same site as the MUC1/TM protein. In contrast, the MUC1/Y isoform, composed of an N-terminally truncated SEA module, is not cleaved. Cysteine or threonine mutations of the MUC1/X serine residue (Ser-63) immediately C-terminal to the cleavage site generated cleaved proteins, whereas mutation of the Ser-63 residue of MUCI/X to any other of 17 amino acids did not result in cleavage. In vitro incubation of highly purified precursor MUC1/X protein resulted in self-cleavage. Furthermore, addition of hydroxylamine, a strong nucleophile, markedly enhanced cleavage. Both these features are signature characteristics of self-cleaving proteins, and we concluded that MUC1 undergoes autoproteolysis mediated by an N↵O-acyl rearrangement at the cleavage site followed by hydrolytic resolution of the unstable ester and concomitant cleavage. It is likely that all cleaved SEA module-containing proteins follow a similar route. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - ADENOCARCINOMA
KW - PROTEINS
KW - PROTEOLYSIS
KW - AMINO acids
KW - SERINE
N1 - Accession Number: 18579827; Levitin, Fiana 1 Stern, Omer 1 Weiss, Mordechai 2 Gil-Henn, Chava 1 Ziv, Ravit 1 Prokocimer, Zofnat 1 Smorodinsky, Nechama I. 1,3 Rubinstein, Daniel B. 4 Wreschner, Daniel H. 1; Email Address: danielhw@post.tau.ac.il; Affiliation: 1: Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv 69978, Israel 2: Department of Endocrinology, Assaf Harofe Medical Center, Tzrifin 70300, Israel 3: Alec and Myra Marmot Hybridoma Laboratory, Tel Aviv University, Ramat Aviv 69978, Israel 4: Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20851; Source Info: 9/30/2005, Vol. 280 Issue 39, p33374; Subject Term: GLYCOPROTEINS; Subject Term: ADENOCARCINOMA; Subject Term: PROTEINS; Subject Term: PROTEOLYSIS; Subject Term: AMINO acids; Subject Term: SERINE; Number of Pages: 13p; Illustrations: 6 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1074/jbc.M506047200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cook, Judith A.
AU - Lehman, Anthony F.
AU - Drake, Robert
AU - McFarlane, William R.
AU - Gold, Paul B.
AU - Left, H. Stephen
AU - Blyler, Crystal
AU - Toprac, Marcia G.
AU - Razzano, Lisa A.
AU - Burke-Miller, Jane K.
AU - Blankertz, Laura
AU - Shafer, Michael
AU - Pickett-Schenk, Susan A.
AU - Grey, Dennis D.
T1 - Integration of Psychiatric and Vocational Services: A Multisite Randomized, Controlled Trial of Supported Employment.
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
Y1 - 2005/10//
VL - 162
IS - 10
M3 - Article
SP - 1948
EP - 1956
SN - 0002953X
AB - Objective: Although large-scale surveys indicate that patients with severe mental illness want to work, their unemployment rate is three to five times that of the general adult population. This multisite, randomized implementation effectiveness trial examined the impact of highly integrated psychiatric and vocational rehabilitation services on the likelihood of successful work outcomes. Method: At seven sites nationwide, 1,273 outpatients with severe mental illness were randomly assigned either to an experimental supported employment program or to a comparison/services-as-usual condition and followed for 24 months. Data collection involved monthly services tracking, semiannual in-person interviews, recording of all paid employment, and program ratings made by using a services-integration measure. The likelihood of competitive employment and working 40 or more hours per month was examined by using mixed-effects random regression analysis. Results: Subjects served by models that integrated psychiatric and vocational service delivery were more than twice as likely to be competitively employed and almost 1½ times as likely to work at least 40 hours per month when the authors controlled for time, demographic, clinical, and work history confounds. In addition, higher cumulative amounts of vocational services were associated with better employment outcomes, whereas higher cumulative amounts of psychiatric services were associated with poorer outcomes. Conclusions: Supported employment models with high levels of integration of psychiatric and vocational services were more effective than models with low levels of service integration. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Psychiatry is the property of American Psychiatric Publishing, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHIATRY
KW - VOCATIONAL rehabilitation
KW - MENTAL health
KW - CLINICAL trials
KW - UNEMPLOYMENT
KW - CORRELATION (Statistics)
N1 - Accession Number: 18544070; Cook, Judith A. 1,2,3,4,5,6,7,8,9,10; Email Address: cook@ripco.com Lehman, Anthony F. 1,2,3,4,5,6,7,8,9,10 Drake, Robert 1,2,3,4,5,6,7,8,9,10 McFarlane, William R. 1,2,3,4,5,6,7,8,9,10 Gold, Paul B. 1,2,3,4,5,6,7,8,9,10 Left, H. Stephen 1,2,3,4,5,6,7,8,9,10 Blyler, Crystal 1,2,3,4,5,6,7,8,9,10 Toprac, Marcia G. 1,2,3,4,5,6,7,8,9,10 Razzano, Lisa A. 1,2,3,4,5,6,7,8,9,10 Burke-Miller, Jane K. 1,2,3,4,5,6,7,8,9,10 Blankertz, Laura 1,2,3,4,5,6,7,8,9,10 Shafer, Michael 1,2,3,4,5,6,7,8,9,10 Pickett-Schenk, Susan A. 1,2,3,4,5,6,7,8,9,10 Grey, Dennis D. 1,2,3,4,5,6,7,8,9,10; Affiliation: 1: University of Illinois, Chicago. 2: University of Maryland, Baltimore. 3: Dartmouth University, Concord, N.H. 4: Maine Medical Center, Portland. 5: Medical University of South Carolina, Charleston. 6: Human Services Research Institute, Cambridge, Mass. 7: Center for Mental Health Services, Rockville, Md. 8: Texas Department of Mental Health, Austin. 9: Connections, CSP Incorporated, Wilmington, Del. 10: University of Arizona, Tucson.; Source Info: Oct2005, Vol. 162 Issue 10, p1948; Subject Term: PSYCHIATRY; Subject Term: VOCATIONAL rehabilitation; Subject Term: MENTAL health; Subject Term: CLINICAL trials; Subject Term: UNEMPLOYMENT; Subject Term: CORRELATION (Statistics); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106540086
T1 - Public health consequences of imprisonment. Behavioral health problems, ex-offender reentry policies, and the 'Second Chance Act'.
AU - Pogorzelski W
AU - Wolff N
AU - Pan K
AU - Blitz CL
Y1 - 2005/10//
N1 - Accession Number: 106540086. Language: English. Entry Date: 20051118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Center for Mental Health Services & Criminal Justice Research through a center grant from the National Institute of Mental Health (grant P20 MH66170). NLM UID: 1254074.
KW - Health Services Needs and Demand
KW - Mental Disorders -- Rehabilitation
KW - Prisoners -- Legislation and Jurisprudence -- United States
KW - Prisoners -- Psychosocial Factors
KW - Public Policy
KW - Rehabilitation, Psychosocial
KW - Adult
KW - Bivariate Statistics
KW - Chi Square Test
KW - Community Programs
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Housing
KW - Male
KW - Middle Age
KW - New Jersey
KW - P-Value
KW - Policy Studies
KW - Public Assistance
KW - Punishment
KW - Sex Factors
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 1718
EP - 1724
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 95
IS - 10
CY - Washington, District of Columbia
PB - American Public Health Association
AB - The federal 'Second Chance Act of 2005' calls for expanding reentry services for people leaving prison, yet existing policies restrict access to needed services for those with criminal records. We examined the interaction between individual-level characteristics and policy-level restrictions related to criminal conviction, and the likely effects on access to resources upon reentry, using a sample of prisoners with Axis I mental disorders (n=3073).We identified multiple challenges related to convictions, including restricted access to housing, public assistance, and other resources. Invisible punishments embedded within existing policies were inconsistent with the call for second chances. Without modification of federal and state policies, the ability of reentry services to foster behavioral health and community reintegration is limited.
SN - 0090-0036
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ 08901; wpogorzelski@ifh.rutgers.edu
U2 - PMID: 16131635.
DO - 10.2105/AJPH.2005.065805
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106540095
T1 - Gender-specific behavior health and community release patterns among New Jersey prison inmates: implications for treatment and community reentry.
AU - Blitz CL
AU - Wolff N
AU - Pan K
AU - Pogorzelski W
Y1 - 2005/10//
N1 - Accession Number: 106540095. Language: English. Entry Date: 20051118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Center for Mental Health Services & Criminal Justice Research through a center grant from the National Institute of Mental Health (grant P20 MH66170). NLM UID: 1254074.
KW - Correctional Health Services
KW - Health Services Needs and Demand -- Evaluation
KW - Mental Disorders
KW - Mental Health Services
KW - Prisoners -- Psychosocial Factors
KW - Rehabilitation, Psychosocial
KW - Sex Factors -- Evaluation
KW - Behavior, Addictive
KW - Chi Square Test
KW - Comorbidity
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Male
KW - Mental Disorders -- Classification
KW - New Jersey
KW - P-Value
KW - Personality Disorders
KW - Poverty
KW - Race Factors
KW - Record Review
KW - Residence Characteristics
KW - Resource Databases
KW - Human
SP - 1741
EP - 1746
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 95
IS - 10
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We describe behavioral health diagnoses and community release patterns among adult male and female inmates in New Jersey prisons and assess their implications for correctional health care and community reentry. METHODS: We used clinical and classification data on a census of 'special needs' inmates (those with behavioral health disorders) in New Jersey (n=3189) and a census of all special needs inmates released to New Jersey communities over a 12-month period (n=974). RESULTS: Virtually all adult inmates with special needs had at least 1 Axis I mental disorder, and 68% of these had at least 1 additional Axis I mental disorder, a personality disorder, or addiction problem (67% of all male and 75% of all female special needs inmates). Of those special needs inmates released, 25% returned to the most disadvantaged counties in New Jersey (27% of all male and 18% of all female special needs inmates). CONCLUSIONS: Two types of clustering were found: gender-specific clustering of disorders among inmates and spatial clustering of ex-offenders in impoverished communities. These findings suggest a need for gendered treatment strategies within correctional settings and need for successful reentry strategies.
SN - 0090-0036
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ 08901; cblitz@ifh.rutgers.edu
U2 - PMID: 16131640.
DO - 10.2105/AJPH.2004.059733
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - DRAKE, PAMELA L.
AU - HAZELWOOD, KYLE J.
T1 - Exposure-Related Health Effects of Silver and Silver Compounds: A Review.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2005/10//
VL - 49
IS - 7
M3 - Article
SP - 575
EP - 585
SN - 00034878
AB - A critical review of studies examining exposures to the various forms of silver was conducted to determine if some silver species are more toxic than others. The impetus behind conducting this review is that several occupational exposure limits and guidelines exist for silver, but the values for each depend on the form of silver as well as the individual agency making the recommendations. For instance, the American Conference of Governmental Industrial Hygienists has established separate threshold limit values for metallic silver (0.1 mg/m3) and soluble compounds of silver (0.01 mg/m3). On the other hand, the permissible exposure limit (PEL) recommended by the Occupational Safety and Health Administration and the Mine Safety and Health Administration and the recommended exposure limit set by the National Institute for Occupational Safety and Health is 0.01 mg/m3 for all forms of silver. The adverse effects of chronic exposure to silver are a permanent bluish-gray discoloration of the skin (argyria) or eyes (argyrosis). Most studies discuss cases of argyria and argyrosis that have resulted primarily from exposure to the soluble forms of silver. Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects, including liver and kidney damage, irritation of the eyes, skin, respiratory, and intestinal tract, and changes in blood cells. Metallic silver appears to pose minimal risk to health. The current occupational exposure limits do not reflect the apparent difference in toxicities between soluble and metallic silver; thus, many researchers have recommended that separate PELs be established. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silver
KW - Metals -- Toxicology
KW - Threshold limit values (Industrial toxicology)
KW - Argyria
KW - United States
KW - argyrosis
KW - occupational exposure
KW - occupational exposure limits
KW - silver
KW - American Conference of Governmental Industrial Hygienists
KW - United States. Occupational Safety & Health Administration
KW - United States. Mine Safety & Health Administration
N1 - Accession Number: 20125697; DRAKE, PAMELA L. 1; Email Address: pdrake@cdc.gov; HAZELWOOD, KYLE J. 1,2; Affiliations: 1: National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Avenue, Spokane, WA 99207, USA; 2: Loyola University Chicago, Stritch School of Medicine, Versailles on the Lakes, 17 W. 704 Butterfield Road #208, Oakbrook Terrace, IL 60153, USA; Issue Info: Oct2005, Vol. 49 Issue 7, p575; Thesaurus Term: Silver; Thesaurus Term: Metals -- Toxicology; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Argyria; Subject: United States; Author-Supplied Keyword: argyrosis; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: occupational exposure limits; Author-Supplied Keyword: silver ; Company/Entity: American Conference of Governmental Industrial Hygienists ; Company/Entity: United States. Occupational Safety & Health Administration ; Company/Entity: United States. Mine Safety & Health Administration; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 11p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1093/annhyg/mei019
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tobias, Herbert J.
AU - Schafer, Millie P.
AU - Pitesky, Maurice
AU - Fergenson, David P.
AU - Horn, Joanne
AU - Frank, Matthias
AU - Gard, Eric E.
T1 - Bioaerosol Mass Spectrometry for Rapid Detection of Individual Airborne Mycobacterium tuberculosis H37Ra Particles.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2005/10//
VL - 71
IS - 10
M3 - Article
SP - 6086
EP - 6095
SN - 00992240
AB - Single-particle laser desorption/ionization time-of-flight mass spectrometry, in the form of bioaerosol mass spectrometry (BAMS), was evaluated as a rapid detector for individual airborne, micron-sized, Mycobacterium tuberculosis H37Ra particles, comprised of a single cell or a small number of clumped cells. The BAMS mass spectral signatures for aerosolized M. tuberculosis H37Ra particles were found to be distinct from M. smegmatis, Bacillus atrophaeus, and B. cereus particles, using a distinct biomarker. This is the first time a potentially unique biomarker was measured in M. tuberculosis H37Ra on a single-cell level. In addition, M. tuberculosis H37Ra and M. smegmatis were aerosolized into a bioaerosol chamber and were sampled and analyzed using BAMS, an aerodynamic particle sizer, a viable Anderson six-stage sampler, and filter cassette samplers that permitted direct counts of cells. In a background-free environment, BAMS was able to sample and detect M. tuberculosis H37Ra at airborne concentrations of >1 M. tuberculosis H37Ra-containing particles/liter of air in 20 min as determined by direct counts of filter cassette-sampled particles, and concentrations of >40 M. tuberculosis H37Ra CFU/liter of air in 1 min as determined by using viable Andersen six-stage samplers. This is a first step toward the development of a rapid, stand-alone airborne M. tuberculosis particle detector for the direct detection of M. tuberculosis bioaerosols generated by an infectious patient. Additional instrumental development is currently under way to make BAMS useful in realistic environmental and respiratory particle backgrounds expected in tuberculosis diagnostic scenarios. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASS spectrometry
KW - MYCOBACTERIUM tuberculosis
KW - TUBERCULIN
KW - CELLS
KW - MYCOBACTERIAL diseases
KW - LUNG diseases
N1 - Accession Number: 18648257; Tobias, Herbert J. 1 Schafer, Millie P. 2 Pitesky, Maurice 1 Fergenson, David P. 1 Horn, Joanne 1 Frank, Matthias 1 Gard, Eric E. 1; Email Address: gard2@llnl.gov; Affiliation: 1: Lawrence Livermore National Laboratory, Livermore, California. 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; Source Info: Oct2005, Vol. 71 Issue 10, p6086; Subject Term: MASS spectrometry; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: TUBERCULIN; Subject Term: CELLS; Subject Term: MYCOBACTERIAL diseases; Subject Term: LUNG diseases; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1128/AEM.71.10.6086-6095.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yigang Sun
AU - Yuanhui Zhang
AU - Aijun Wang
AU - Topmiller, Jennifer L.
AU - Bennet, James S.
T1 - Experimental Characterization of Airflows in Aircraft Cabins, Part I: Experimental System and Measurement Procedure.
JO - ASHRAE Transactions
JF - ASHRAE Transactions
Y1 - 2005/10//
VL - 111
IS - 2
M3 - Article
SP - 45
EP - 52
PB - ASHRAE
SN - 00012505
AB - Airflow patterns and air velocity within an aircraft cabin have profound effects on the thermal environment and air quality around passengers. To characterize airflows in air cabins experimentally, a full-scale, five-row section of a jumbo aircraft cabin was constructed. Each row had seven passenger seats. The mockup was a wood structure based on the actual dimensions of the Boeing 767 aircraft cabin. Inside the passenger cabin, actual aircraft equipment, including seats, internal panels, and air diffusers, formed the boundary of the cabin airspace. The construction of the mock air cabin included the fuselage, air supply system, a data acquisition system, and software for data processing. A unique volumetric particle streak velocimetry (VPSV) method was used to measure air velocity profiles. The VPSV technique overcomes many limitations in airflow measurement and has features such as being non intrusive, full-scale, three-dimensional, and instantaneous. This paper discusses the experimental systems and the air velocity measurement procedures. The data collected with the system described here is reported in Part II of this work. [ABSTRACT FROM AUTHOR]
AB - Copyright of ASHRAE Transactions is the property of ASHRAE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR flow
KW - AIRCRAFT cabins
KW - SPEED
KW - MEASUREMENT
KW - AIR quality
KW - SEATING (Furniture)
KW - AIRPLANES -- Fuselage
KW - PASSENGERS
KW - ELECTRONIC data processing
N1 - Accession Number: 19414057; Yigang Sun 1 Yuanhui Zhang 2 Aijun Wang 1 Topmiller, Jennifer L. 3 Bennet, James S. 4; Affiliation: 1: Department of Agricultural Engineering, University of Illinois, Urbana-Champaign. 2: Professor, Department of Agricultural Engineering, University of Illinois, Urbana-Champaign. 3: Mechanical Engineer, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. 4: Senior Service Fellow, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention.; Source Info: 2005, Vol. 111 Issue 2, p45; Subject Term: AIR flow; Subject Term: AIRCRAFT cabins; Subject Term: SPEED; Subject Term: MEASUREMENT; Subject Term: AIR quality; Subject Term: SEATING (Furniture); Subject Term: AIRPLANES -- Fuselage; Subject Term: PASSENGERS; Subject Term: ELECTRONIC data processing; NAICS/Industry Codes: 336410 Aerospace product and parts manufacturing; NAICS/Industry Codes: 336413 Other Aircraft Parts and Auxiliary Equipment Manufacturing; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuanhui Zhang
AU - Yigang Sun
AU - Aijun Wang
AU - Topmiller, Jennifer L.
AU - Bennett, James S.
T1 - Experimental Characterization of Airflows in Aircraft Cabins, Part II: Results and Research Recommendations.
JO - ASHRAE Transactions
JF - ASHRAE Transactions
Y1 - 2005/10//
VL - 111
IS - 2
M3 - Article
SP - 53
EP - 59
PB - ASHRAE
SN - 00012505
AB - Air distribution is one of the most important factors determining thermal comfort and transport of airborne contaminants in aircraft cabins. Improvement of air quality in such airspaces is limited by the difficulties in simultaneously measuring the air velocity profile within the entire flow field. Measurement of the airflow field using a new technique, volumetric particle streak velocimetry (VPSV), within aircraft cabins, therefore, has value both theoretically and practically. In this project, quantitative full-cabin air velocities in a full-scale aircraft cabin section were measured under nine experimental conditions (e.g., iso- and nonisothermal, different obstruction configurations,). Obstruction configurations in the cabin had a substantial effect on the air velocity at the passenger breathing level. At 100% passenger occupancy capacity, air speed at the passenger breathing level had the least variation and the empty cabin had the largest. A cold fuselage wall under in-flight conditions increased the air speed and may induce drafts for passengers at window seats. The highest air speeds at the window seats were measured at 0.538, 0.382, and 0.228 m/s for empty, 50%, and 100% occupancy, respectively. Air speeds higher than 0.3 m/s could cause an uncomfortable draft for temperature -sensitive passengers. Sonic seats downstream from the supply air jet had air speeds as low as 0. 034 m/s. Air velocity data presented in this paper are best treated as snapshots rather than mean values for one model of aircraft. Although pollutant concentrations or air ages were not measured at the point of velocity measurements in this study, such low air speed could indicate long mean air age and poor ventilation effectiveness. Further investigations are needed to establish zonal net air exchange rate and local (individual passenger) ventilation effectiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of ASHRAE Transactions is the property of ASHRAE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR flow
KW - AIRCRAFT cabins
KW - AIR quality
KW - THERMAL conductivity
KW - AIR pollution
KW - MEASUREMENT
KW - PASSENGERS
KW - RESPIRATION
KW - AIRPLANES -- Fuselage
N1 - Accession Number: 19414058; Yuanhui Zhang 1 Yigang Sun 2 Aijun Wang 2 Topmiller, Jennifer L. 3 Bennett, James S. 4; Affiliation: 1: Professor, Department of Agricultural Engineering, University of Illinois at Urbana-Champaign, Urbana, Ill. 2: Department of Agricultural Engineering, University of Illinois at Urbana-Champaign, Urbana, Ill. 3: Mechanical Engineer, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. 4: Senior Service Fellow, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention.; Source Info: 2005, Vol. 111 Issue 2, p53; Subject Term: AIR flow; Subject Term: AIRCRAFT cabins; Subject Term: AIR quality; Subject Term: THERMAL conductivity; Subject Term: AIR pollution; Subject Term: MEASUREMENT; Subject Term: PASSENGERS; Subject Term: RESPIRATION; Subject Term: AIRPLANES -- Fuselage; NAICS/Industry Codes: 336410 Aerospace product and parts manufacturing; NAICS/Industry Codes: 336413 Other Aircraft Parts and Auxiliary Equipment Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Lawrence W.
AU - Collins, Jerry M.
AU - Klecker, Raymond W.
AU - Katki, Aspandiar G.
AU - Parchment, Ralph E.
AU - Boinpally, Ramesh R.
AU - LoRusso, Patricia M.
AU - Ivy, S. Percy
T1 - Metabolic profile of XK469 (2( R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug–drug interactions.
JO - Cancer Chemotherapy & Pharmacology
JF - Cancer Chemotherapy & Pharmacology
Y1 - 2005/10//
VL - 56
IS - 4
M3 - Article
SP - 351
EP - 357
SN - 03445704
AB - As part of an ongoing phase 1 study, we studied the excretion of XK469 and its metabolism in patients and in vitro. Five primary metabolites were identified by HPLC/MS/MS. An oxidized product formed by cytosolic aldehyde oxidase was the predominant species both in urine and human hepatocytes in vitro. Conjugates of XK469 with glycine, taurine, and glucuronic acid, as well as the microsomal product, 4-oxo-XK469, were also found in urine and in vitro, but none were major contributors to the mass balance for XK469 elimination. Based upon the relative concentrations circulating in plasma, systemic exposure to parent drug was 100-fold higher than for the metabolites. Thus, both toxicity and efficacy of XK469 are most likely to be produced by the parent molecule, rather than the metabolites. Urinary recovery of parent drug was low (2% of dose in 24 h), partly because of the long half-life of XK469 (approximately 3 days). In addition, the metabolite profile in urine indicates that only 25% of the XK469-derived material was unchanged drug. Thus, urinary excretion was not a major factor in XK469 elimination. Variations in systemic exposure to XK469 will be strongly influenced by factors that alter the activity of aldehyde oxidase, including pharmacogenetics, enzyme inhibition, and enzyme induction, but no specific modifiers have been reported. The multiday half-life of XK469 hampered our ability to obtain a complete mass balance, and the possibility exists that other routes, such as biliary excretion, may also play a substantial role in XK469 disposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Physiological effect
KW - METABOLITES
KW - ALDEHYDES
KW - EXCRETION
KW - CYTOSOL
KW - GLYCINE
KW - TAURINE
KW - GLUCURONIC acid
KW - Drug-drug interactions
KW - Metabolites
KW - NSC698215
N1 - Accession Number: 17743125; Anderson, Lawrence W. 1,2; Email Address: ANDERSONL@cder.fda.gov Collins, Jerry M. 2 Klecker, Raymond W. 2 Katki, Aspandiar G. 2 Parchment, Ralph E. 3 Boinpally, Ramesh R. 3 LoRusso, Patricia M. 3 Ivy, S. Percy 4; Affiliation: 1: Food and Drug Administration, WO Bldg 64, Rm 2014, 10903 New Hampshire Avenue, HFD-902, Silver Spring, MD, 20993 2: Laboratory of Clinical Pharmacology, Food and Drug Administration, Silver Spring, MD, USA 3: Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA 4: Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, MD, USA; Source Info: Oct2005, Vol. 56 Issue 4, p351; Subject Term: DRUGS -- Physiological effect; Subject Term: METABOLITES; Subject Term: ALDEHYDES; Subject Term: EXCRETION; Subject Term: CYTOSOL; Subject Term: GLYCINE; Subject Term: TAURINE; Subject Term: GLUCURONIC acid; Author-Supplied Keyword: Drug-drug interactions; Author-Supplied Keyword: Metabolites; Author-Supplied Keyword: NSC698215; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s00280-004-0962-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Henneberger, Paul K.
AU - Olin, Anna-Carvin
AU - Andersson, Eva
AU - Hagberg, Stig
AU - Torén, Kjell
T1 - The Incidence of Respiratory Symptoms and Diseases Among Pulp Mill Workers With Peak Exposures to Ozone and Other Irritant Gases.
JO - CHEST
JF - CHEST
Y1 - 2005/10//
VL - 128
IS - 4
M3 - Article
SP - 3028
EP - 3037
SN - 00123692
AB - The article provides information on a study that investigates whether the incidence of selected respiratory outcomes was associated with peak exposures to ozone or other irritant gases used in pulp mills in Sweden. Bleachery worker from three pulp mills where ozone was used participated in surveys in the mid- to late-1990s. Based on proportional hazards regression, workers who reported both ozone and ClO2/SO2 peak exposures had elevated hazard ratios (HR) for all the outcomes. Those who reported only ozone peak exposures had elevated HR of 6.5 for asthma and 3.3 for attacks of wheeze but no increase in risk for chronic bronchitis.
KW - PAPER mills
KW - OBSTRUCTIVE lung diseases
KW - BLEACHING materials
KW - OZONE
KW - HEALTH surveys
KW - SWEDEN
KW - asthma
KW - irritant gases
KW - occupation
KW - ozone
N1 - Accession Number: 18769876; Henneberger, Paul K. 1; Email Address: pkh0@cdc.gov Olin, Anna-Carvin 2 Andersson, Eva 2 Hagberg, Stig 2 Torén, Kjell 3; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV. 2: Sections of Occupational and Environmental Medicine, Göteborg, Sweden. 3: Allergology, Sahlgrenska University Hospital, Göteborg, Sweden.; Source Info: Oct2005, Vol. 128 Issue 4, p3028; Subject Term: PAPER mills; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: BLEACHING materials; Subject Term: OZONE; Subject Term: HEALTH surveys; Subject Term: SWEDEN; Author-Supplied Keyword: asthma; Author-Supplied Keyword: irritant gases; Author-Supplied Keyword: occupation; Author-Supplied Keyword: ozone; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 322122 Newsprint Mills; NAICS/Industry Codes: 322121 Paper (except Newsprint) Mills; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106119677
T1 - The incidence of respiratory symptoms and diseases among pulp mill workers with peak exposures to ozone and other irritant gases.
AU - Henneberger PK
AU - Olin A
AU - Andersson E
AU - Hagberg S
AU - Torén K
Y1 - 2005/10//
N1 - Accession Number: 106119677. Language: English. Entry Date: 20070720. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: American Thoracic Society respiratory questionnaire. Grant Information: Swedish Council for Worklife and Social Research (FAS), Swedish Heart and Lung Foundation. NLM UID: 0231335.
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Prevention and Control
KW - Ozone -- Adverse Effects
KW - Respiratory Tract Diseases -- Chemically Induced
KW - Asthma -- Epidemiology
KW - Asthma -- Prevention and Control
KW - Asthma -- Risk Factors
KW - Bronchitis -- Epidemiology
KW - Bronchitis -- Prevention and Control
KW - Bronchitis -- Risk Factors
KW - Chlorine -- Adverse Effects
KW - Confidence Intervals
KW - Cox Proportional Hazards Model
KW - Data Analysis Software
KW - Fisher's Exact Test
KW - Funding Source
KW - Gases
KW - Industry
KW - Occupational Diseases -- Epidemiology
KW - Occupational Diseases -- Prevention and Control
KW - Odds Ratio
KW - Oxides -- Adverse Effects
KW - Questionnaires
KW - Respiratory Sounds -- Etiology
KW - Respiratory Tract Diseases -- Epidemiology
KW - Respiratory Tract Diseases -- Prevention and Control
KW - Sweden
KW - T-Tests
KW - Human
SP - 3028
EP - 3037
JO - CHEST
JF - CHEST
JA - CHEST
VL - 128
IS - 4
CY - Glenview, Illinois
PB - American College of Chest Physicians
AB - OBJECTIVES: Pulp mills in Sweden started to use ozone as a bleaching agent in the early 1990s. The goal of this study was to investigate whether the incidence of selected respiratory outcomes was associated with peak exposures to ozone or other irritant gases (ie, chlorine dioxide [ClO2] or sulfur dioxide [SO2]) used in these mills. METHODS: Bleachery workers (n = 245) from three pulp mills where ozone was used participated in surveys in the mid- to late-1990s. Comparison workers (n = 80) were from two adjacent paper mills. The person-time at risk was calculated for each participant, covering the period of employment when ozone was used. Data were collected by questionnaire, and a peak exposure was defined as a self-reported exposure to an irritant gas resulting in acute respiratory symptoms. The outcomes analyzed were self-reports of physician-diagnosed asthma, attacks of wheeze, and chronic bronchitis (ie, chronic cough with phlegm). Participants also reported when the peak exposures and outcomes occurred. RESULTS: Based on proportional hazards regression (controlling for gender, age, cigarette smoking, atopy, and peak irritant exposures that occurred before follow-up), workers who reported both ozone and ClO2/SO2 peak exposures had elevated hazard ratios (HRs) for all three outcomes. Those who reported only ozone peak exposures had elevated HRs of 6.5 (95% confidence interval [CI], 1.2 to 36.3) for asthma and 3.3 (95% CI, 1.1 to 10.2) for attacks of wheeze but no increase in risk for chronic bronchitis. Workers with only ClO2/SO2 peak exposures had elevated HRs for attacks of wheeze (HR, 7.5; 95% CI, 1.9 to 29.3) and chronic bronchitis (HR, 22.9; 95% CI, 4.5 to 118.2) but not for asthma. CONCLUSIONS: These findings suggest the need for additional efforts to prevent peak exposures in pulp-bleaching operations.
SN - 0012-3692
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-H2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA. pkh0@cdc.gov
U2 - PMID: 16236983.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Seed, Jennifer
AU - Carney, Edward
AU - Corley, Richard
AU - Crofton, Kevin
AU - DeSesso, John
AU - Foster, Paul
AU - Kavlock, Robert
AU - Kimmel, Gary
AU - Klaunig, James
AU - Meek, M.
AU - Preston, R.
AU - Slikker Jr., William
AU - Tabacova, Sonia
AU - Williams, Gary
AU - Wiltse, Jeanette
AU - Zoeller, R.
AU - Fenner-Crisp, Penelope
AU - Patton, Dorothy
T1 - Overview: Using Mode of Action and Life Stage Information to Evaluate the Human Relevance of Animal Toxicity Data.
JO - Critical Reviews in Toxicology
JF - Critical Reviews in Toxicology
Y1 - 2005/10//Oct/Nov2005
VL - 35
IS - 8/9
M3 - Article
SP - 663
EP - 672
PB - Taylor & Francis Ltd
SN - 10408444
AB - A complete mode of action human relevance analysis—as distinct from mode of action (MOA) analysis alone—depends on robust information on the animal MOA, as well as systematic comparison of the animal data with corresponding information from humans. In November 2003, the International Life Sciences Institute's Risk Science Institute (ILSI RSI) published a 2-year study using animal and human MOA information to generate a four-part Human Relevance Framework (HRF) for systematic and transparent analysis of MOA data and information. Based mainly on non-DNA-reactive carcinogens, the HRF features a “concordance” analysis of MOA information from both animal and human sources, with a focus on determining the appropriate role for each MOA data set in human risk assessment. With MOA information increasingly available for risk assessment purposes, this article illustrates the further applicability of the HRF for reproductive, developmental, neurologic, and renal endpoints, as well as cancer. Based on qualitative and quantitative MOA considerations, the MOA/human relevance analysis also contributes to identifying data needs and issues essential for the dose-response and exposure assessment steps in the overall risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Life sciences
KW - Animals
KW - Health risk assessment
KW - Carcinogens
KW - Mechanism of action (Biochemistry)
KW - Human beings
KW - DNA
KW - Neurology
KW - Developmental Window
KW - Human Relevance Framework
KW - Noncancer Modes of Action
KW - Risk Assessment
N1 - Accession Number: 18908830; Seed, Jennifer 1; Carney, Edward 2; Corley, Richard 3; Crofton, Kevin 4; DeSesso, John 5; Foster, Paul 6; Kavlock, Robert 4; Kimmel, Gary 7; Klaunig, James 8; Meek, M. 9; Preston, R. 4; Slikker Jr., William 10; Tabacova, Sonia 11; Williams, Gary 12; Wiltse, Jeanette 7; Zoeller, R. 13; Fenner-Crisp, Penelope 14; Patton, Dorothy 14; Email Address: dpatton@ilsi.org; Affiliations: 1: U.S. Environmental Protection Agency, Washington, DC, USA; 2: The Dow Chemical Company, Midland, Michigan, USA; 3: Pacific Northwest National Laboratory, Richland, , Washington, USA; 4: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 5: Mitretek Systems, Falls Church, Virginia, USA; 6: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; 7: U.S. Environmental Protection Agency (retired), Washington, DC, USA; 8: Indiana University School of Medicine, Indianapolis, Indianapolis, USA; 9: Health Canada, Ottawa, Ontario, Canada; 10: National Center for Toxicological Research, Jefferson, Arkansas, USA; 11: Food and Drug Administration, Rockville, Maryland, USA; 12: New York Medical College, Valhalla, New York, USA; 13: University of Massachusetts-Amherst, Amherst, Massachusetts, USA; 14: ILSI Risk Science Institute, Washington, DC, USA; Issue Info: Oct/Nov2005, Vol. 35 Issue 8/9, p663; Thesaurus Term: Life sciences; Thesaurus Term: Animals; Thesaurus Term: Health risk assessment; Thesaurus Term: Carcinogens; Subject Term: Mechanism of action (Biochemistry); Subject Term: Human beings; Subject Term: DNA; Subject Term: Neurology; Author-Supplied Keyword: Developmental Window; Author-Supplied Keyword: Human Relevance Framework; Author-Supplied Keyword: Noncancer Modes of Action; Author-Supplied Keyword: Risk Assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1080/10408440591007133
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tabacova, Sonia
T1 - Mode of Action: Angiotensin-Converting Enzyme Inhibition—Developmental Effects Associated With Exposure to ACE Inhibitors.
JO - Critical Reviews in Toxicology
JF - Critical Reviews in Toxicology
Y1 - 2005/10//Oct/Nov2005
VL - 35
IS - 8/9
M3 - Article
SP - 747
EP - 755
PB - Taylor & Francis Ltd
SN - 10408444
AB - Relative to species tested in laboratory studies, the human fetus displays higher vulnerability to enalapril and other angiotensin-converting enzyme inhibitors (ACEI) exhibiting a malformative syndrome that does not appear to have a similar counterpart in experimental animals. An important reason for this higher vulnerability is the earlier intrauterine development of the kidney and the renin–angiotensin–aldosterone (RAS) system in humans, organ systems that are specific targets of ACEI's pharmacological effect. In humans, these systems begin developing prior to the onset of skeletal ossification at the end of the first trimester, with continuing vulnerability throughout the pregnancy. In most animal species tested, these target systems develop close to term, when the fetus is relatively more mature and less vulnerable to the effects of developmental toxicants. For this reason, animal studies that follow standard protocols and evaluate developmental toxicity only for exposures during embryogenesis will miss developmental effects arising secondary to disruption of target systems that develop after the period of major organogenesis. Thus, although the animal mode of action (MOA) for enalapril and other ACEI is plausible in humans, differences in the timing of development of critical target organ systems, particularly the renal system and RAS, explain the absence of definitive structural abnormalities in test animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enzyme inhibitors
KW - Human abnormalities
KW - Fetus
KW - Angiotensins
KW - Fetal development
KW - Morphogenesis
KW - Somatic embryogenesis
KW - ACEI Fetopathy
KW - Animal-Human Prenatal Development
KW - Congenital Abnormalities
KW - Critical Exposure Timing
KW - Human Relevance
KW - Renin–Angiotensin System
KW - Renin-Angiotensin System
N1 - Accession Number: 18908840; Tabacova, Sonia 1; Email Address: tabacovas@cder.fda.gov; Affiliations: 1: U.S. Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Oct/Nov2005, Vol. 35 Issue 8/9, p747; Thesaurus Term: Enzyme inhibitors; Thesaurus Term: Human abnormalities; Subject Term: Fetus; Subject Term: Angiotensins; Subject Term: Fetal development; Subject Term: Morphogenesis; Subject Term: Somatic embryogenesis; Author-Supplied Keyword: ACEI Fetopathy; Author-Supplied Keyword: Animal-Human Prenatal Development; Author-Supplied Keyword: Congenital Abnormalities; Author-Supplied Keyword: Critical Exposure Timing; Author-Supplied Keyword: Human Relevance; Author-Supplied Keyword: Renin–Angiotensin System; Author-Supplied Keyword: Renin-Angiotensin System; Number of Pages: 9p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/10408440591007160
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18908840&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Farshid, Mahmood
AU - Taffs, Rolf E
AU - Scott, Dorothy
AU - Asher, David M
AU - Brorson, Kurt
T1 - The clearance of viruses and transmissible spongiform encephalopathy agents from biologicals
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
Y1 - 2005/10//
VL - 16
IS - 5
M3 - Article
SP - 561
EP - 567
SN - 09581669
AB - The viral and transmissible spongiform encephalopathy (TSE) safety of therapeutics of biological origin (biologicals) is greatly influenced by the nature and degree of variability of the source material and by the mode of purification. Plasma-derived and recombinant DNA products currently have good viral safety records, but challenges remain. In general, large enveloped viruses are easier to remove from biologicals than small ‘naked’ viruses. Monoclonal antibodies and recombinant DNA biopharmaceuticals are derived from relatively homogeneous source materials and purified by multistep schemes that are robust and amenable to scientific analysis and engineering improvement. Viral clearance is more challenging for blood and cell products, as they are complex and labile. Source selection (e.g. country of origin, deferral for CJD risk factors) currently occupies the front line for ensuring that biologicals are free of TSE agents, but robust methods for their clearance from products are under development. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Biotechnology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC wasting disease
KW - THERAPEUTICS
KW - BIOLOGICALS
KW - DNA
KW - VIRUSES
KW - MONOCLONAL antibodies
KW - RECOMBINANT DNA
KW - BLOOD
N1 - Accession Number: 18628157; Farshid, Mahmood 1 Taffs, Rolf E 1 Scott, Dorothy 1 Asher, David M 1 Brorson, Kurt 2; Email Address: kurt.brorson@fda.hhs.go; Affiliation: 1: Office of Blood Research and Review, Center for Biologics Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA 2: Research and Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda Maryland 20892, USA; Source Info: Oct2005, Vol. 16 Issue 5, p561; Subject Term: CHRONIC wasting disease; Subject Term: THERAPEUTICS; Subject Term: BIOLOGICALS; Subject Term: DNA; Subject Term: VIRUSES; Subject Term: MONOCLONAL antibodies; Subject Term: RECOMBINANT DNA; Subject Term: BLOOD; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.copbio.2005.07.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Misbin, Robert I.
T1 - Evaluating the Safety of Diabetes Drugs.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2005/10//
VL - 28
IS - 10
M3 - Article
SP - 2573
EP - 2576
SN - 01495992
AB - This article describes the process by which the U.S. Food and Drug Administration (FDA) evaluates safety data relating to diabetes drugs. Problems had been facing FDA for years. In 2004 came the recognition that widely used antidepressants were associated with suicide in young patients, and then came the withdrawal of Vioxx. Drugs in diabetes and metabolism have not been spared. The obesity drug Meridia and the lipid-lowering agent Crestor are two of the five drugs whose safety was challenged by FDA epidemiologist Dr. David Graham in testimony before a U.S. Senate committee. Unique among drug withdrawals is the diabetes drug phenformin, which was declared an imminent hazard and was removed from the market in 1977 because of lactic acidosis. One lesson that should be learned from these examples is that it is hazardous to make firm conclusions about the safety of a new drug. The approval of a new drug is based on safety data from a few thousand patients treated under the intense medical supervision of a clinical trial. Diabetes drugs have typically been approved based on trials involving a few thousand patients. Although some important information is derived from short-term trials, the most important pre-approval safety data come from results of phase 3 trials. These trials generally last from 16 to 52 weeks and compare various doses of the test drug to placebo or to another drug that has already been approved. Phase 3 trials are useful for identifying safety issues that are reasonably common but not large enough to detect adverse events that are rare. In many cases, phase 3 trials generate signals that need to be evaluated further. The FDA may require that approval of a new drug be contingent on the manufacturer's commitment to do additional safety studies after approval.
KW - DRUG development
KW - PHARMACOLOGY
KW - PHARMACY
KW - CLINICAL trials
KW - PLACEBOS (Medicine)
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 18549120; Misbin, Robert I. 1; Email Address: misbinr@cder.fda.gov; Affiliation: 1: Division of Endocrine and Metabolic Drug Products, Food and Drug Administration, Rockville, Maryland; Source Info: Oct2005, Vol. 28 Issue 10, p2573; Subject Term: DRUG development; Subject Term: PHARMACOLOGY; Subject Term: PHARMACY; Subject Term: CLINICAL trials; Subject Term: PLACEBOS (Medicine); Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 3608
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106354068
T1 - Evaluating the safety of diabetes drugs: perspective of a Food and Drug Administration insider.
AU - Misbin RI
Y1 - 2005/10//
N1 - Accession Number: 106354068. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975.
KW - Diabetes Mellitus -- Drug Therapy
KW - Drug Approval
KW - Hypoglycemic Agents -- Therapeutic Use
KW - United States Food and Drug Administration
SP - 2573
EP - 2576
JO - Diabetes Care
JF - Diabetes Care
JA - DIABETES CARE
VL - 28
IS - 10
CY - Alexandria, Virginia
PB - American Diabetes Association
SN - 0149-5992
AD - Division of Endocrine and Metabolic Drug Products, Food and Drug Administration, 5727 Crawford Dr., Rockville, MD 20851; misbinr@cder.fda.gov
U2 - PMID: 16186303.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Earnest, G. Scott
AU - Gressel, Michael G.
AU - Mead, Kenneth R.
T1 - Using Filtration Systems To Protect Building Environments From Airborne Chemicals, Biological, Or Radiological Attacks.
JO - Engineered Systems
JF - Engineered Systems
Y1 - 2005/10//
VL - 22
IS - 10
M3 - Article
SP - 38
EP - 47
PB - BNP Media
SN - 08919976
AB - Focuses on the use of filtration systems to protect building environments from airborne chemicals, biological or radiological attack in the U.S. Types of threats and filters; Life cycle cost and changeout schedule.
KW - OFFICE buildings -- Environmental aspects
KW - BUILDINGS -- Environmental engineering
KW - FILTERS & filtration
KW - BUILDING -- Safety measures
KW - UNITED States
N1 - Accession Number: 18622538; Earnest, G. Scott 1 Gressel, Michael G. 2 Mead, Kenneth R.; Affiliation: 1: Research Engineer, CDC, NIOSH 2: Captain, U.S. Public Health Service, Occupational Health and Safety Engineer, National Institute for Occupational Safety and Health (NIOSH), Center for Disease Control and Prevention (CDC); Source Info: Oct2005, Vol. 22 Issue 10, p38; Subject Term: OFFICE buildings -- Environmental aspects; Subject Term: BUILDINGS -- Environmental engineering; Subject Term: FILTERS & filtration; Subject Term: BUILDING -- Safety measures; Subject Term: UNITED States; NAICS/Industry Codes: 334512 Automatic Environmental Control Manufacturing for Residential, Commercial, and Appliance Use; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cheeseman, M. A.
T1 - Thresholds as a unifying theme in regulatory toxicology.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2005/10//
VL - 22
IS - 10
M3 - Article
SP - 900
EP - 906
PB - Taylor & Francis Ltd
SN - 0265203X
AB - The scientific basis for the US Food and Drug Administration (FDA) threshold of regulation is discussed in relation to its toxicological testing recommendations for food contact substances and the existing methods it employs for exposure estimation. A case is made that the FDA's threshold of regulation is a natural extension of its toxicity testing regime. The genetic toxicity tests recommended in the exposure-based toxicological testing framework for food contact substances are examined regarding their ability to predict positively carcinogens of varying potency. In addition, the computational toxicology program MULTICASE v. 3.1 is also examined for its ability to predict positively carcinogens of varying potency. It is concluded that MULTICASE can provide equivalent results to genetic toxicity tests at the lowest dietary concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Toxicology
KW - Genetics
KW - Carcinogens
KW - Toxicity testing
KW - United States
KW - computational toxicology
KW - genetic toxicity tests
KW - MULTICASE
KW - Threshold of regulation
KW - threshold of regulation (TOR)
KW - United States. Food & Drug Administration
N1 - Accession Number: 18565734; Cheeseman, M. A. 1; Email Address: Mitchell.Cheeseman@FDA.Gov; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Parkway, College Park, MD 20740, USA; Issue Info: Oct2005, Vol. 22 Issue 10, p900; Thesaurus Term: Food -- Toxicology; Thesaurus Term: Genetics; Thesaurus Term: Carcinogens; Thesaurus Term: Toxicity testing; Subject: United States; Author-Supplied Keyword: computational toxicology; Author-Supplied Keyword: genetic toxicity tests; Author-Supplied Keyword: MULTICASE; Author-Supplied Keyword: Threshold of regulation; Author-Supplied Keyword: threshold of regulation (TOR) ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/02652030500150143
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Begley, T. H.
AU - White, K.
AU - Honigfort, P.
AU - Twaroski, M. L.
AU - Neches, R.
AU - Walker, R. A.
T1 - Perfluorochemicals: Potential sources of and migration from food packaging.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2005/10//
VL - 22
IS - 10
M3 - Article
SP - 1023
EP - 1031
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Perfluorochemicals are widely used in the manufacturing and processing of a vast array of consumer goods, including electrical wiring, clothing, household and automotive products. Furthermore, relatively small quantities of perfluorochemicals are also used in the manufacturing of food-contact substances that represent potential sources of oral exposure to these chemicals. The most recognizable products to consumers are the uses of perfluorochemicals in non-stick coatings (polytetrafluoroethylene (PTFE)) for cookware and also their use in paper coatings for oil and moisture resistance. Recent epidemiology studies have demonstrated the presence of two particular perfluorochemicals, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in human serum at very low part per billion levels. These perfluorochemicals are biopersistent and are the subject of numerous studies investigating the many possible sources of human exposure. Among the various uses of these two chemicals, PFOS is a residual impurity in some paper coatings used for food contact and PFOA is a processing aid in the manufacture of PTFE used for many purposes including non-stick cookware. Little information is available on the types of perfluorochemicals that have the potential to migrate from perfluoro coatings into food. One obstacle to studying migration is the difficulty in measuring perfluorochemicals by routine conventional analytical techniques such as GC/MS or LC-UV. Many perfluorochemicals used in food-contact substances are not detectable by these conventional methods. As liquid chromatography-mass spectrometry (LC/MS) develops into a routine analytical technique, potential migrants from perfluoro coatings can be more easily characterized. In this paper, data will be presented on the types of perfluoro chemicals that are used in food packaging and cookware. Additionally, research will be presented on the migration or potential for migration of these chemicals into foods or food simulating liquids. Results from migration tests show mg kg -1 amounts of perfluoro paper additives/coatings transfer to food oil. Analysis of PTFE cookware shows residual amounts of PFOA in the low µg kg -1 range. PFOA is present in microwave popcorn bag paper at amounts as high as 300 µg kg -1 . [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Organofluorine compounds
KW - Food industry
KW - Chemicals
KW - Polytef
KW - Plastic coatings
KW - Serum
KW - food packaging
KW - migration
KW - perfluoro telomers
KW - Perfluorochemicals
KW - perfluorooctanoic acid
N1 - Accession Number: 18565744; Begley, T. H. 1; Email Address: tbegley@cfsan.fda.gov; White, K. 1; Honigfort, P. 1; Twaroski, M. L. 1; Neches, R. 2; Walker, R. A. 2; Affiliations: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; 2: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA; Issue Info: Oct2005, Vol. 22 Issue 10, p1023; Thesaurus Term: Organofluorine compounds; Thesaurus Term: Food industry; Subject Term: Chemicals; Subject Term: Polytef; Subject Term: Plastic coatings; Subject Term: Serum; Author-Supplied Keyword: food packaging; Author-Supplied Keyword: migration; Author-Supplied Keyword: perfluoro telomers; Author-Supplied Keyword: Perfluorochemicals; Author-Supplied Keyword: perfluorooctanoic acid; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/02652030500183474
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chesley, Francis D.
AU - Clancy, Carolyn M.
AD - Unlisted
AD - Agency for Healthcare Research and Quality, Washington, DC
T1 - Research Funding Opportunities: Fiscal Year 2006
JO - Health Services Research
JF - Health Services Research
Y1 - 2005/10//
VL - 40
IS - 5
SP - xi
EP - xiv
SN - 00179124
N1 - Accession Number: 0828809; Publication Type: Journal Article; Update Code: 200604
KW - Miscellaneous Categories: Other Y90
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291475-6773/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Klein, K. S.
AU - Thompson, D.
AU - Scheidt, P. C.
AU - Overpeck, M. D.
AU - Gross, L. A.
T1 - Factors associated with bicycle helmet use among young adolescents in a multinational sample.
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
Y1 - 2005/10//
VL - 11
IS - 5
M3 - Article
SP - 288
EP - 293
SN - 13538047
AB - Objective: To determine factors associated with variation in bicycle helmet use by youth of different industrialized countries. Design: A multinational cross sectional nationally representative survey of health behaviors including symptoms, risk taking, school selling, and family context. Selling: School based survey of 26 countries. Subjects: School students, ages 11, 13, and 15 years totaling 112 843. Outcome measures: Reported frequency of bicycle helmet use among bicycle riders. Results: Reported helmet use varied greatly by country from 39.2% to 1.9%, with 12 countries reporting less than 10% of the bicycle riders as frequent helmet users and 14 countries more than 10%. Reported helmet use was highest at 11 years and decreased as children's age increased. Use was positively associated with other healthy behaviors, with parental involvement, and with per capita gross domestic product of the country. It is negatively associated with risk taking behaviors. Countries reported to have interventions promoting helmet use, exemplified by helmet giveaway programmes, had greater frequency of reported helmet use than those without programmes. Conclusions: Bicycle helmet use among young adolescents varies greatly between countries; however, helmet use does not reach 50% in any country. Age is the most significant individual factor associated with helmet for helmet using countries. The observation that some helmet promotion programmes are reported for countries with relatively higher student helmet use and no programmes reported for the lowest helmet use countries, suggests the possibility of a relation and the need for objective evaluation of programme effectiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Injury Prevention (1353-8047) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BICYCLE helmets
KW - TEENAGERS
KW - CYCLISTS
KW - SAFETY hats
KW - SURVEYS
KW - HEALTH behavior
N1 - Accession Number: 18848967; Klein, K. S. 1 Thompson, D. 2 Scheidt, P. C. 1; Email Address: Scheidtp@nih.gov Overpeck, M. D. 1,3 Gross, L. A. 4; Affiliation: 1: National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA. 2: Maryland Medical Research Institute, Baltimore, MD, USA. 3: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA. 4: Macro International Inc., Calverton, MD, USA.; Source Info: Oct2005, Vol. 11 Issue 5, p288; Subject Term: BICYCLE helmets; Subject Term: TEENAGERS; Subject Term: CYCLISTS; Subject Term: SAFETY hats; Subject Term: SURVEYS; Subject Term: HEALTH behavior; NAICS/Industry Codes: 339920 Sporting and Athletic Goods Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1136/ip.2004.007013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18848967&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Driscoll, T.
AU - Marsh, S.
AU - McNoe, B.
AU - Langley, J.
AU - Stout, N.
AU - Feyer, A.-M.
AU - Williamson, A.
T1 - Comparison of Fatalities From work related motor vehicle traffic incidents in Australia, New Zealand, and the United States.
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
Y1 - 2005/10//
VL - 11
IS - 5
M3 - Article
SP - 294
EP - 299
SN - 13538047
AB - Objective: To compare the extent and characteristics of motor vehicle traffic incidents on public roads resulting in fatal occupational injuries in Australia, New Zealand (NZ), and the United States (US). Design and setting: Information came from separate data sources in Australia (1989-92), NZ (1985-98), and the US (1989-92). Methods: Using data systems based on vital records, distributions and rates of fatal injuries resulting from motor vehicle traffic incidents were compared for the three countries. Common inclusion criteria and occupation and industry classifications were used to maximize comparability. Results: Motor vehicle traffic incident related deaths accounted For 16% (NZ), 22% (US), and 31% (Australia) of all work related deaths during the years covered by the studies. Australia had a considerably higher crude rate (1 .69 deaths/i 00 000 person years; 95% confidence interval (95% CI) 1 .54 to 1.83) compared with both NZ (0.99; 95% Cl 0.85 to 1.12) and the US (0.92; 95% CI 0.89 to 0.94). Industry distribution differences accounted for only a small proportion of this variation in rates. Case selection issues may have accounted for some of the remainder, particularly in NZ. In all three countries, male workers, older workers, and truck drivers were at higher risk. Conclusions: Motor vehicle traffic incidents are an important cause of work related death of workers in Australia, NZ, and the US. The absolute rates appear to differ between the three countries, but most of the incident characteristics were similar. Lack of detailed data and inconsistencies between the data sets limit the extent to which more in-depth comparisons could be made. [ABSTRACT FROM AUTHOR]
AB - Copyright of Injury Prevention (1353-8047) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRAFFIC accidents
KW - WORK-related injuries
KW - TRANSPORTATION accidents
KW - NEW Zealand
KW - AUSTRALIA
KW - UNITED States
N1 - Accession Number: 18848969; Driscoll, T. 1; Email Address: elmatom@optushome.com.au Marsh, S. 2 McNoe, B. 3 Langley, J. 3 Stout, N. 2 Feyer, A.-M. 4,5 Williamson, A. 6; Affiliation: 1: ELMATOM Pty Ltd and School of Public Health, University of Sydney, NSW, Australia. 2: National Institute for Occupational Safety and Health, Morgantown, WV, USA. 3: Injury Prevention Research Unit, Department of Preventive and Social Medicine, University of Otago, New Zealand. 4: Department of Preventive and Social Medicine, University of Otago, New Zealand. 5: Health Advisory Practice, Price Waterhouse Coopers. 6: NSW Injury Risk Management Research Centre, University of New South Wales, Australia.; Source Info: Oct2005, Vol. 11 Issue 5, p294; Subject Term: TRAFFIC accidents; Subject Term: WORK-related injuries; Subject Term: TRANSPORTATION accidents; Subject Term: NEW Zealand; Subject Term: AUSTRALIA; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1136/ip.2004.008094
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tomaso, Herbert
AU - Al Dahouk, Sascha
AU - Hofer, Erwin
AU - Splettstoesser, Wolf D.
AU - Treu, Thomas M.
AU - Dierich, Manfred P.
AU - Neubauer, Heinrich
T1 - Antimicrobial susceptibilities of Austrian Francisella tularensis holarctica biovar II strains
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2005/10//
VL - 26
IS - 4
M3 - Article
SP - 279
EP - 284
SN - 09248579
AB - Abstract: The antibiotic susceptibilities of 50 Francisella tularensis subsp. holarctica biovar II strains isolated from hares and human patients from the eastern part of Austria were examined. Minimum inhibitory concentrations (MICs) of 24 antimicrobial agents were determined using Etests™ on cysteine heart agar plates supplemented with 10% sheep blood. All isolates were sensitive to tetracyclines, aminoglycosides, quinolones, chloramphenicol and rifampicin. Resistance was observed in all isolates against macrolides, penicillins and aztreonam. Bacteria were resistant to cephalosporins and carbapenems, except for 8% of strains investigated that were susceptible or intermediately susceptible. Our in vitro susceptibility data can be applied for the detection and comparison of resistance development and to provide in vitro data for the guidance of therapy. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gram-negative bacteria
KW - Antibiotics
KW - Beta lactam antibiotics
KW - Cephalosporins
KW - Antibiotic susceptibility
KW - Biovar II
KW - Francisella tularensis subsp. holarctica
KW - MIC
N1 - Accession Number: 18342792; Tomaso, Herbert 1; Email Address: herberttomaso@bundeswehr.org; Al Dahouk, Sascha 1; Hofer, Erwin 2; Splettstoesser, Wolf D. 3; Treu, Thomas M. 4; Dierich, Manfred P. 5; Neubauer, Heinrich 1; Affiliations: 1: Bundeswehr Institute of Microbiology, Neuherbergstraße 11, 80937 Munich, Germany; 2: Agentur fuer Gesundheit und Ernaehrungssicherheit, Veterinaermedizinische Untersuchungen Moedling, Robert Koch–Gasse 17, 2340 Moedling, Austria; 3: Splettstoesser, Bundeswehr Institute of Microbiology, Neuherbergstraße 11, 80937 Munich, Germany; 4: Office of the Surgeon General, Military Hospital Vienna, Bruennerstraße 238, 1210 Wien, Austria; 5: Institute for Hygiene and Social Medicine, University of Innsbruck, Fritz-Pregl-Straße 3, 6020 Innsbruck, Austria; Issue Info: Oct2005, Vol. 26 Issue 4, p279; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Antibiotics; Subject Term: Beta lactam antibiotics; Subject Term: Cephalosporins; Author-Supplied Keyword: Antibiotic susceptibility; Author-Supplied Keyword: Biovar II; Author-Supplied Keyword: Francisella tularensis subsp. holarctica; Author-Supplied Keyword: MIC; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2005.07.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Wu, John Z.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
T1 - Estimation of Vibration Power Absorption Density in Human Fingers.
JO - Journal of Biomechanical Engineering
JF - Journal of Biomechanical Engineering
Y1 - 2005/10//
VL - 127
IS - 5
M3 - Article
SP - 849
EP - 856
SN - 01480731
AB - The absorption of hand-transmitted vibration energy may be an etiological factor in vibration-induced disorders. The vibration power absorption density (VPAD) may be a better measure of energy than the total power absorption of the hand-arm system. The objectives of the present study are to develop a method to estimate the average absorption density in the fingers and to investigate its basic characteristics. Ten healthy male subjects were used in this study. The biodynamic response of the fingers in a power grip subjected to a broad-band random excitation was measured under three grip forces (15, 30, 50 N) and three push forces (35, 45, 50 N). The response was used to estimate the total finger energy absorption. The response, together with the finger volume, was also used to estimate the amount of tissue effectively involved in the absorption. Then, the average VPAD under constant-acceleration, constant-power density, constant-velocity vibration spectra, and 20 tool vibration spectra were calculated. The correlations between the VPAD and the unweighted and weighted accelerations (ISO 5349-1, 2001) were also examined. The VPAD depends on both the characteristics of the vibration spectrum and the biodynamic response of the finger-hand-arm system. The biodynamic response generally plays a more important role in determining the VPAD in the middle frequency range (31.5-400 Hz) than those at the low and high ends. The applied force significantly affected the VPAD. The finger VPAD was highly correlated to the unweighted acceleration. The average VPAD can be determined using the proposed experimental method. It can serve as an alternative tool to quantify the severity of the vibration exposure for studying vibration-induced finger disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomechanical Engineering is the property of American Society of Mechanical Engineers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FINGERS
KW - HAND
KW - VIBRATION (Mechanics)
KW - FORCE & energy
KW - BIOMECHANICS
N1 - Accession Number: 18335962; Dong, Ren G. 1; Email Address: rkd6@cdc.gov Wu, John Z. 1 Welcome, Daniel E. 1 McDowell, Thomas W. 1; Affiliation: 1: Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Source Info: Oct2005, Vol. 127 Issue 5, p849; Subject Term: FINGERS; Subject Term: HAND; Subject Term: VIBRATION (Mechanics); Subject Term: FORCE & energy; Subject Term: BIOMECHANICS; Number of Pages: 8p; Illustrations: 2 Diagrams, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1115/1.1992526
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Lee, Vincent H. L.
T1 - Editorial: A Tribute to Professor A.T. Florence for his Life-time Research Achievements.
JO - Journal of Drug Targeting
JF - Journal of Drug Targeting
Y1 - 2005/10//
VL - 13
IS - 8/9
M3 - Editorial
SP - 447
EP - 448
PB - Taylor & Francis Ltd
SN - 1061186X
AB - This article is a tribute to Professor A. T. Florence upon his selection as the recipient of the 2005 "Journal of Drug Targeting" Life-time Research Achievement Award. He has many contributions to research in the mechanisms of self-association of surfactants and surfactant-like monomers and in understanding the diverse array of nanostructures. His educational background include a PhD from the University of Glasgow at the age of 25.
KW - DRUG targeting
KW - PERIODICALS
KW - AWARDS
KW - SURFACE active agents
KW - DOSAGE forms of drugs
KW - MONOMERS
KW - FLORENCE, A. T.
N1 - Accession Number: 19063422; Lee, Vincent H. L. 1; Affiliation: 1: Food and Drug Administration, Office of Pharmaceutical Science, HFD-03 Rockville, MD 20852, USA; Source Info: Oct2005, Vol. 13 Issue 8/9, p447; Subject Term: DRUG targeting; Subject Term: PERIODICALS; Subject Term: AWARDS; Subject Term: SURFACE active agents; Subject Term: DOSAGE forms of drugs; Subject Term: MONOMERS; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; People: FLORENCE, A. T.; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1080/10611860500410862
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hastings, Kenneth L.
T1 - Prospects for Developmental Immunotoxicity Guidance and an Update on ICH S8.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2005/10//
VL - 2
IS - 4
M3 - Article
SP - 217
EP - 220
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Potential adverse effects of drug exposure on the developing immune system had been a relatively neglected area of toxicology until fairly recently. However, with the recent regulatory emphasis on evaluation of drugs for use in pediatric patients, juvenile animal studies have been considered in much more detail than in the past in order to enable clinical trials. Assessment of immunotoxicity potential in these juvenile animal studies has been a natural consequence of drug development for pediatric patients. Unfortunately, the efforts to evaluate developmental immunotoxicity studies have not kept pace with the writing of an immunotoxicology guidance for the International Conference on Harmonisation of Technical Requirements for Registration of Human Pharmaceuticals (ICH). This document has recently reached Step 4 in the approval process: it is thus likely that juvenile animal studies for immunotoxicity would be recommended based on considerations enumerated in the ICH Safety Number 8 (S8) guidance. Sufficient flexibility exists in this document to cover the issue of developmental immunotoxicity. ICH S8 advocates a weight-of-evidence approach, which should be interpreted to indicate that immunotoxicity testing would be conducted based on identified cause(s) for concern rather than as a routine screening method. The presentation reflecting these issues, as presented to attendees of the Pharmaceutical Education Associates workshop on Innovative Methods and Applications for Risk Assessment in Pharmaceutical Development is summarized herein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Drugs
KW - Immunotoxicology
KW - Immune system
KW - Pediatrics
KW - Clinical trials
KW - developmental immunotoxicology
KW - ICH S8
N1 - Accession Number: 18970656; Hastings, Kenneth L. 1; Email Address: hastingsk@cder.fda.gov; Affiliations: 1: Office of New Drugs, Center for Drug Evaluation and Research USFDA, Rockville, Maryland, USA; Issue Info: Oct2005, Vol. 2 Issue 4, p217; Thesaurus Term: Toxicology; Thesaurus Term: Drugs; Subject Term: Immunotoxicology; Subject Term: Immune system; Subject Term: Pediatrics; Subject Term: Clinical trials; Author-Supplied Keyword: developmental immunotoxicology; Author-Supplied Keyword: ICH S8; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/15476910500387173
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ijaz, Samreen
AU - Arnold, Eve
AU - Banks, Malcolm
AU - Bendall, Richard P.
AU - Cramp, Matthew E.
AU - Cunningham, Richard
AU - Dalton, Harry R.
AU - Harrison, Tim J.
AU - Hill, Simon F.
AU - MacFarlane, Lorna
AU - Meigh, Rolf E.
AU - Shafi, Shuja
AU - Sheppard, Martin J.
AU - Smithson, Jacquie
AU - Wilson, Melanie P.
AU - Chong-Gee Teo
T1 - Non-Travel-Associated Hepatitis E in England and Wales: Demographic, Clinical, and Molecular Epidemiological Characteristics.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/10//10/1/2005
VL - 192
IS - 7
M3 - Article
SP - 1166
EP - 1172
SN - 00221899
AB - Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were 155 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travelassociated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS E
KW - VIRAL hepatitis
KW - LIVER diseases
KW - PATIENTS
KW - ENGLAND
KW - WALES
N1 - Accession Number: 18331136; Ijaz, Samreen 1 Arnold, Eve 2 Banks, Malcolm 3 Bendall, Richard P. 4 Cramp, Matthew E. 5 Cunningham, Richard 6 Dalton, Harry R. 7 Harrison, Tim J. 8 Hill, Simon F. 9 MacFarlane, Lorna 10 Meigh, Rolf E. 11 Shafi, Shuja 12 Sheppard, Martin J. 13 Smithson, Jacquie 14 Wilson, Melanie P. 15 Chong-Gee Teo 1; Affiliation: 1: Virus Reference Division, University College London, London. 2: Statistics Unit, Centre for Infections, Health Protection Agency, University College London, London. 3: Mammalian Virology, Veterinary Laboratories Agency, New Haw, United Kingdom. 4: Department of Clinical Microbiology, Royal Cornwall Hospital, Truro, United Kingdom. 5: Department of Gastroenterology, Unit, United Kingdom. 6: Department of Microbiology, Derriford Hospital, Plymouth, United Kingdom. 7: Department of Gastroenterology, Royal Cornwall Hospital, Truro, United Kingdom. 8: Windeyer Institute of Medical Sciences, University College London, London. 9: Department of Microbiology, Poole Hospital, Poole, United Kingdom. 10: National Public Health Service Microbiology Aberystwyth, Bronglais General Hospital, Aberystwyth, United Kingdom. 11: Department of Microbiology, Castle Hill Hospital, Cottingham, United Kingdom. 12: Department of Microbiology, Northwick Park Hospital, Harrow, United Kingdom. 13: Department of Microbiology, Withybush General Hospital, Haverfordwest, United Kingdom. 14: Department of Gastroenterology, Royal Infirmary, Hull, United Kingdom. 15: Department of Microbiology, County Hospital, Hereford, United Kingdom.; Source Info: 10/1/2005, Vol. 192 Issue 7, p1166; Subject Term: HEPATITIS E; Subject Term: VIRAL hepatitis; Subject Term: LIVER diseases; Subject Term: PATIENTS; Subject Term: ENGLAND; Subject Term: WALES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106540529
T1 - AHRQ commentary. Working conditions that support patient safety.
AU - Hughes RG
AU - Clancy CM
Y1 - 2005/10//Oct-Dec2005
N1 - Accession Number: 106540529. Language: English. Entry Date: 20051118. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Patient Safety
KW - Health Care Errors
KW - Nursing Management
KW - Nursing Practice
KW - Personnel Staffing and Scheduling
KW - United States Agency for Healthcare Research and Quality
KW - Work Environment
SP - 289
EP - 292
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 20
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Room 6052, Rockville, MD 20850; rhughes@ahrq.gov
U2 - PMID: 16177577.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106544805
T1 - Test for the integrity of environmental tractor cab filtration systems.
AU - Moyer ES
AU - Heitbrink WA
AU - Jensen PA
Y1 - 2005/10//
N1 - Accession Number: 106544805. Language: English. Entry Date: 20051125. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D79-80. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Occupational Exposure -- Prevention and Control
KW - Respiratory Protective Devices -- Evaluation
KW - Education, Continuing (Credit)
KW - Farmworkers
KW - Human
SP - 516
EP - 523
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Cab filtration systems can be used to protect vehicle operators from hazardous air contaminants. In a cab filtration system, a fan draws air through filters and pressurizes the cab with this filtered air. This article describes the application of a low-cost, optical particle counter to evaluate the performance of tractor cab filtration systems. The tractors were equipped with environmental enclosures to protect the operators from pesticide exposures that occur during air blast spraying in orchards. Prior to testing, all environmental tractor cabs underwent a complete maintenance overhaul followed by a careful inspection by the manufacturer's field representative. As part of this maintenance effort, 13 tractors with cab filtration systems were tested in an enclosure. A Met One model 227B two-channel optical particle counter was used to measure the aerosol concentration outside and inside the cab. Ambient aerosol and/or aerosol generated by burning incense sticks were used to challenge the stationary cab filtration system in an enclosure. The ratio of the outside to inside concentration (Co/Ci) is the exposure reduction attained by the cab system. Alternatively, the inside concentration divided by the outside concentration times 100 (Ci/Co x 100) gives the percent penetration. All 13 tractors were tested for leak sites. Leak sites were identified and sealed. This process was repeated until each cab showed an exposure reduction ratio Co/Ci of at least 50 (aerosol penetration into the cab Ci/Co x 100 was less than 2%) at the 0.3-0.5 microm particle size interval.
SN - 1545-9624
AD - Division of Respiratiory Disease Studies, Laboratory Research Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 1095 Willowdale Road, Mail Stop H2800.4, Morgantown, WV 26505; esm2@cdc.gov
U2 - PMID: 16183625.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Potthast, H.
AU - Dressman, J. B.
AU - Junginger, H. E.
AU - Midha, K. K.
AU - Oeser, H.
AU - Shah, V. P.
AU - Vogelpoel, H.
AU - Barends, D. M.
T1 - Biowaiver monographs for immediate release solid oral dosage forms: Ibuprofen.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2005/10//
VL - 94
IS - 10
M3 - Article
SP - 2121
EP - 2131
SN - 00223549
AB - Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences in composition and/or manufacturing procedures were reported to have an effect on the rate, but not the extent of absorption; such differences are likely to be detectable by comparative in vitro dissolution tests. Also in view of its therapeutic use, its wide therapeutic index and uncomplicated pharmacokinetic properties, a biowaiver for immediate release (IR) ibuprofen solid oral drug products is scientifically justified, provided that the test product contains only those excipients reported in this paper in their usual amounts, the dosage form is rapidly dissolving (85% in 30 min or less) in buffer pH 6.8 and the test product also exhibits similar dissolution profiles to the reference product in buffer pH 1.2, 4.5, and 6.8. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:2121-2131, 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IBUPROFEN
KW - BIOPHARMACEUTICS
KW - SOLID dosage forms
KW - ORAL medication
KW - DOSAGE forms of drugs
KW - absorption
KW - biopharmaceutics classification system(BCS)
KW - ibuprofen
KW - permeability
KW - solubility
N1 - Accession Number: 22171271; Potthast, H. 1 Dressman, J. B. 2 Junginger, H. E. 3 Midha, K. K. 4 Oeser, H. 5 Shah, V. P. 6 Vogelpoel, H. 7 Barends, D. M. 7; Email Address: Dirk.Barends@RIVM.nl; Affiliation: 1: Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, Bonn, Germany 2: Institut für Pharmazeutische Technologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany 3: Center for Drug Research, Leiden University, Division of Pharmaceutical Technology, Leiden, The Netherlands 4: University of Saskatchewan, Saskatoon, Saskatchewan, Canada 5: Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany 6: Center of Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 7: RIVM, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Source Info: Oct2005, Vol. 94 Issue 10, p2121; Subject Term: IBUPROFEN; Subject Term: BIOPHARMACEUTICS; Subject Term: SOLID dosage forms; Subject Term: ORAL medication; Subject Term: DOSAGE forms of drugs; Author-Supplied Keyword: absorption; Author-Supplied Keyword: biopharmaceutics classification system(BCS); Author-Supplied Keyword: ibuprofen; Author-Supplied Keyword: permeability; Author-Supplied Keyword: solubility; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1002/jps.20444
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prodduturi, Suneela
AU - Manek, Rahul V.
AU - Kolling, William M.
AU - Stodghill, Steven P.
AU - Repka, Michael A.
T1 - Solid-state stability and characterization of hot-melt extruded poly(ethylene oxide) films.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2005/10//
VL - 94
IS - 10
M3 - Article
SP - 2232
EP - 2245
SN - 00223549
AB - Poly(ethylene oxide) (PEO) was used to prepare thin polymer films containing clotrimazole (CT) utilizing hot-melt extrusion (HME) technology. Films containing PEOs of two different molecular weights and the drug were investigated for solid-state characteristics, moisture-sorption, bioadhesivity, mechanical properties, release characteristics, and physical and chemical stability of the drug within the HME films. The solid-state characterization of the drug and the polymer were performed utilizing differential scanning calorimetry and X-ray diffractometry. A Texture analyzer was utilized to study the bioadhesive and mechanical properties of the HME films. Physical and chemical stability of the films, stored at 25°C/60% RH, was studied for up to 12 months. XRD profiles indicated that the drug was physically unstable (recrystallization of the drug occurred) after storage for 3 months at 25°C/60% RH. Based on the DSC studies, it has been proposed that the recrystallization of the drug may be due to the folding (due to HME) and unfolding (upon storage) of the linear PEO chains. Desirable bioadhesive, mechanical, and thermoplastic properties of PEO qualify it as a promising and potential drug carrier. However, further investigation is necessary to enhance the physical stability of these PEO–drug systems. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 94:2232–2245, 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHYLENE oxide
KW - THIN films
KW - SOLID state chemistry
KW - POLYMERS
KW - MOLECULAR weights
KW - crystallinity
KW - hot-melt extrusion
KW - polymers
KW - solid solutions
KW - solid state stability
KW - thermal analysis
N1 - Accession Number: 22171266; Prodduturi, Suneela 1 Manek, Rahul V. 2 Kolling, William M. 2 Stodghill, Steven P. 3 Repka, Michael A. 3; Email Address: marepka@olemiss.edu; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101 2: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71209 3: Department and Pharmaceutics and The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677; Source Info: Oct2005, Vol. 94 Issue 10, p2232; Subject Term: ETHYLENE oxide; Subject Term: THIN films; Subject Term: SOLID state chemistry; Subject Term: POLYMERS; Subject Term: MOLECULAR weights; Author-Supplied Keyword: crystallinity; Author-Supplied Keyword: hot-melt extrusion; Author-Supplied Keyword: polymers; Author-Supplied Keyword: solid solutions; Author-Supplied Keyword: solid state stability; Author-Supplied Keyword: thermal analysis; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 14p; Illustrations: 6 Charts, 11 Graphs; Document Type: Article
L3 - 10.1002/jps.20437
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whiting, Susan J.
AU - Calvo, Mona S.
T1 - Dietary recommendations to meet both endocrine and autocrine needs of Vitamin D
JO - Journal of Steroid Biochemistry & Molecular Biology
JF - Journal of Steroid Biochemistry & Molecular Biology
Y1 - 2005/10//
VL - 97
IS - 1/2
M3 - Article
SP - 7
EP - 12
SN - 09600760
AB - Abstract: In the most recent revision of the dietary recommendations for Americans and Canadians in 1997, a recommended intake for Vitamin D was set in the absence of an estimation of mean requirements. There are now new data to estimate average requirements; however, there must be consideration of factors affecting need in populations and of total body tissue needs including the prevention and treatment of cancer. A recent study provides dietary dose–response data in the absence of sun exposure, and a mean requirement of 12.5μg (500IU) was found for Caucasian men. A seasonal build up (summer) and waning (winter) of Vitamin D stores implies that the requirement of Vitamin D in complete absence of yearly summertime sun exposure would approach levels of intake that mimic Vitamin D gained from sun exposure. High prevalence of Vitamin D insufficiency and the re-emergence of rickets have been observed worldwide. For many countries without mandatory staple food fortification, Vitamin D intake is often too low to sustain healthy circulating levels of 25 hydroxyvitamin D. Even in some countries that require (mandatory) or allow fortification (optional), Vitamin D intakes are low in some groups due to their unique dietary patterns, such as low milk consumption, vegetarian diet, limited or no use of dietary supplements, or changes away from traditional food consumption. Supplement use can significantly increase Vitamin D intakes across all age and gender groups but the benefit is primarily gained in persons whose intakes are close to adequate. African American men and women have greater prevalence of Vitamin D insufficiency, which may be a factor in their susceptibility to certain cancers. New recommendations for Vitamin D should be made for the otherwise healthy populations in greatest need of dietary Vitamin D due to lack of adequate sun exposure. [Copyright &y& Elsevier]
AB - Copyright of Journal of Steroid Biochemistry & Molecular Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STEROID hormones
KW - FAT-soluble vitamins
KW - CANCER treatment
KW - VITAMIN D
KW - Dietary reference intakes
KW - Functional indicators
KW - Supplementation
KW - Vitamin D
KW - Vitamin D fortification
KW - Vitamin D intakes
N1 - Accession Number: 18980932; Whiting, Susan J. 1; Email Address: susan.whiting@usask.ca Calvo, Mona S. 2; Email Address: mona.calvo@cfsan.fda.gov; Affiliation: 1: College of Pharmacy and Nutrition, 110 Science Place, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5C9 2: Center for Food Safety and Applied Nutrition (CFSAN), Food and Drug Administration MOD-1 Building, HFS-025, 8301 Muirkirk Road, Laurel, MD 20910, USA; Source Info: Oct2005, Vol. 97 Issue 1/2, p7; Subject Term: STEROID hormones; Subject Term: FAT-soluble vitamins; Subject Term: CANCER treatment; Subject Term: VITAMIN D; Author-Supplied Keyword: Dietary reference intakes; Author-Supplied Keyword: Functional indicators; Author-Supplied Keyword: Supplementation; Author-Supplied Keyword: Vitamin D; Author-Supplied Keyword: Vitamin D fortification; Author-Supplied Keyword: Vitamin D intakes; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jsbmb.2005.06.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18980932&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MARTINEZ, M.
AU - CLARK, J.
AU - DUNHAM, B.
AU - HUNTER, R. P.
AU - LANGSTON, C.
AU - LUCAS, A.
AU - JORDAN, D.
T1 - American Academy of Veterinary Pharmacology and Therapeutics 14th Biennial Symposium.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2005/10//
VL - 28
IS - 5
M3 - Article
SP - 495
EP - 498
PB - Wiley-Blackwell
SN - 01407783
AB - Reports on the 14th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics held in Rockville, Maryland. Theme of the symposium; Individuals awarded during the event for their contribution to the promotion of veterinary pharmacology; Developments in the field of veterinary pharmacology highlighted during the symposium.
KW - VETERINARY pharmacology
KW - CONFERENCES & conventions
KW - PHARMACOLOGY
KW - VETERINARY medicine
KW - ROCKVILLE (Md.)
KW - MARYLAND
N1 - Accession Number: 18473465; MARTINEZ, M. 1 CLARK, J. 2 DUNHAM, B. 1 HUNTER, R. P. 2 LANGSTON, C. 3 LUCAS, A. 2 JORDAN, D. 3; Affiliation: 1: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Rockville, MD 2: Elanco Animal Health, Greenfield, IN 3: Mississippi State University College of Veterinary Medicine, Mississippi, MS, USA; Source Info: Oct2005, Vol. 28 Issue 5, p495; Subject Term: VETERINARY pharmacology; Subject Term: CONFERENCES & conventions; Subject Term: PHARMACOLOGY; Subject Term: VETERINARY medicine; Subject Term: ROCKVILLE (Md.); Subject Term: MARYLAND; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1365-2885.2005.00679.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18473465&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Shawn C.
AU - Bauer, Steven R.
AU - Beyer, Richard P.
AU - Brenton, James D.
AU - Bromley, Bud
AU - Burrill, John
AU - Causton, Helen
AU - Conley, Michael P.
AU - Elespuru, Rosalie
AU - Fero, Michael
AU - Foy, Carole
AU - Fuscoe, James
AU - Xiaolian Gao
AU - Gerhold, David Lee
AU - Gilles, Patrick
AU - Goodsaid, Federico
AU - Xu Guo
AU - Hackett, Joe
AU - Hockett, Richard D.
AU - Ikonomi, Pranvera
T1 - The External RNA Controls Consortium: a progress report.
JO - Nature Methods
JF - Nature Methods
Y1 - 2005/10//
VL - 2
IS - 10
M3 - Article
SP - 731
EP - 734
SN - 15487091
AB - Reports that the External RNA Controls Consortium is developing commonly agreed-upon and tested controls for use in gene expression arrays. Controls for evaluating technical performance in gene expression assays performed by microarray or quantitative real-time reverse transcriptase polymerase chain reaction analysis; Specification document.
KW - GENE expression
KW - DNA microarrays
KW - IMMOBILIZED nucleic acids
KW - BIOCHIPS
KW - POLYMERASE chain reaction
KW - REVERSE transcriptase
N1 - Accession Number: 18446166; Baker, Shawn C. 1 Bauer, Steven R. 2 Beyer, Richard P. 3 Brenton, James D. 4 Bromley, Bud 5 Burrill, John 6 Causton, Helen 7 Conley, Michael P. 8 Elespuru, Rosalie 9 Fero, Michael 10 Foy, Carole 11 Fuscoe, James 12 Xiaolian Gao 13 Gerhold, David Lee 14 Gilles, Patrick 15 Goodsaid, Federico 16 Xu Guo 17 Hackett, Joe 18 Hockett, Richard D. 19 Ikonomi, Pranvera 20; Affiliation: 1: Illumina, Inc., 9885 Towne Centre Drive, San Diego, California 92121, USA 2: US Food and Drug Administration, Center for Biologics Evaluation and Research, Building 29B/2NN12, HFM-521, 1401 Rockville Pike, Rockville, Maryland 20852, USA 3: University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, USA 4: Cambridge University, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK 5: ViaLogy Corporation, 2400 Lincoln Avenue, Altadena, California 91001, USA 6: Applied Biosystems, 850 Lincoln Center Drive, Foster City, California 94404, USA 7: University of London, Imperial College of London, London SW7 2AZ, UK 8: Enzo Life Sciences, Inc., 60 Executive Boulevard, Farmingdale, New York 11735, USA 9: US Food and Drug Administration, Center for Devices and Radiological Health, Federal Laboratories at White Oak, Life Sciences Building 64, Room 3020, 10903 New Hampshire Avenue, Silver Spring, Maryland 20903, USA 10: Stanford University School of Medicine, CCSR 4256, 269 Campus Drive, Stanford, California 94305, USA 11: LGC, Bio-Molecular Innovation, Queens Road, Teddington TW11OLY, UK 12: US Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, HFT-020, Jefferson, Arkansas 72079, USA 13: Atactic Technology, Inc., 2575 W. Bellfort, Suite 270, Houston, Texas 77054, USA 14: Merck Research Laboratories, Department of Molecular Profiling, West Point, Pennsylvania 19486, USA 15: Invitrogen Corporation, 1600 Faraday Avenue, P.O. Box 6482, Carlsbad, California 92008, USA 16: US Food and Drug Administration, Center for Drug Evaluation and Research, 1451 Rockville Pike (HFD-860), Woodmont II Office 2078, Rockville, Maryland 20852, USA 17: Affymetrix Inc., 3380 Central Expressway, Santa Clara, California 95051, USA 18: US Food and Drug Administration, Center for Devices and Radiological Health, HFZ-440, 2098 Oak Grove, Rockville, Maryland 20850, USA 19: Eli Lilly and Company, Lilly Research Lab, Lilly Corporate Center, Indianapolis, Indiana 46285, USA 20: American Type Culture Collection, 10801 University Boulevard, Manassas, Virginia 20110, USA; Source Info: Oct2005, Vol. 2 Issue 10, p731; Subject Term: GENE expression; Subject Term: DNA microarrays; Subject Term: IMMOBILIZED nucleic acids; Subject Term: BIOCHIPS; Subject Term: POLYMERASE chain reaction; Subject Term: REVERSE transcriptase; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1038/nmeth1005-731
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perlman, W.R.
AU - Matsumoto, M.
AU - Beltaifa, S.
AU - Hyde, T.M.
AU - Saunders, R.C.
AU - Webster, M.J.
AU - Rubinow, D.R.
AU - Kleinman, J.E.
AU - Weickert, C.S.
T1 - Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex
JO - Neuroscience
JF - Neuroscience
Y1 - 2005/10//
VL - 134
IS - 1
M3 - Article
SP - 81
EP - 95
SN - 03064522
AB - Abstract: Although estrogen receptor alpha (ERα) mRNA has been detected in the primate frontal cortex, the types of ERα transcripts expressed, including exon-deleted variants (Δ), have not been determined in the monkey or human frontal cortex. Because the types of ERα mRNA expressed in brain could define neuronal responses to estrogens, we examined the transcript pool of ERα mRNAs expressed in normal adult and developing human and macaque frontal cortex. We reverse transcribed total RNA from the postmortem frontal cortex of 29 normal adult humans, 12 rhesus macaques, and 19 people ranging from infants to adults and employed two rounds of nested polymerase chain reaction (PCR) to generate ERα products spanning the coding domain. In a third nested PCR, we used primers specific for novel sequences of exon–exon junctions created when whole exons are missing. By sequencing PCR products, we detected 60 instances of 12 distinct ΔERα mRNAs in adult humans and 94 instances of 13 distinct ΔERα mRNAs in monkeys in differing patterns from one individual to another. In adult humans, 83% of individuals expressed at least 1 ΔERα mRNA variant, and 100% of the monkeys expressed at least 1 ΔERα mRNA variant. The single Δ2, Δ5, and Δ7 variants were frequently expressed in both human and monkey frontal cortex, Δ3 variants were rare in both species, and Δ6 variants were more frequently expressed in monkeys. In both species, we detected double, triple and quadruple Δs, but these were less common than single Δs. The pattern of human variant expression did not appear to change dramatically as a function of age. These findings imply the potential to produce different ERα proteins in frontal cortex, possibly with altered structure and function which may have physiological relevance for gene transcription by virtue of altered functional interactions with each other, other steroid hormone receptors, and genomic DNA. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - STEROID hormones
KW - MESSENGER RNA
KW - POLYMERASE chain reaction
KW - base pair ( bp )
KW - brain
KW - estrogen receptor alpha ( ERα )
KW - gene expression
KW - hormone
KW - isoform
KW - monkey
KW - National Institute of Mental Health ( NIMH )
KW - polymerase chain reaction ( PCR )
KW - postmortem interval ( PMI )
KW - reverse transcriptase ( RT )
KW - splicing
N1 - Accession Number: 18132813; Perlman, W.R. 1; Email Address: perlmanw@intra.nimh.nih.gov Matsumoto, M. 2 Beltaifa, S. 1 Hyde, T.M. 1 Saunders, R.C. 3 Webster, M.J. 4 Rubinow, D.R. 5 Kleinman, J.E. 1 Weickert, C.S. 1; Affiliation: 1: Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, 10 Center Drive, Room 4N313C, Bethesda, MD 20892-1385, USA 2: Genomics Research, Yamanouchi Pharmaceutical Co., Ltd., Tsukuba, Ibaraki 305-8585, Japan 3: Laboratory of Neuropsychology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA 4: Stanley Foundation Laboratory of Brain Research, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA 5: Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Oct2005, Vol. 134 Issue 1, p81; Subject Term: GENE expression; Subject Term: STEROID hormones; Subject Term: MESSENGER RNA; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: base pair ( bp ); Author-Supplied Keyword: brain; Author-Supplied Keyword: estrogen receptor alpha ( ERα ); Author-Supplied Keyword: gene expression; Author-Supplied Keyword: hormone; Author-Supplied Keyword: isoform; Author-Supplied Keyword: monkey; Author-Supplied Keyword: National Institute of Mental Health ( NIMH ); Author-Supplied Keyword: polymerase chain reaction ( PCR ); Author-Supplied Keyword: postmortem interval ( PMI ); Author-Supplied Keyword: reverse transcriptase ( RT ); Author-Supplied Keyword: splicing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.neuroscience.2005.03.055
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106397253
T1 - Rapidly progressive coal workers' pneumoconiosis in the United States: geographic clustering and other factors.
AU - Antao VCS
AU - Petsonk EL
AU - Sokolow LZ
AU - Wolfe AL
AU - Pinheiro GA
AU - Hale JM
AU - Attfield MD
Y1 - 2005/10//
N1 - Accession Number: 106397253. Language: English. Entry Date: 20060217. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Mining
KW - Pneumoconiosis -- Epidemiology
KW - Adult
KW - Appalachian Region
KW - Cluster Analysis
KW - Descriptive Statistics
KW - Disease Progression
KW - Epidemiological Research
KW - Lung -- Radiography
KW - Male
KW - Middle Age
KW - Prevalence
KW - United States
KW - Human
SP - 670
EP - 674
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 62
IS - 10
PB - BMJ Publishing Group
AB - BACKGROUND: Despite significant progress made in reducing dust exposures in underground coal miners in the United States, severe cases of coal workers' pneumoconiosis (CWP), including progressive massive fibrosis (PMF), continue to occur among coal miners. AIMS: To identify US miners with rapidly progressive CWP and to describe their geographic distribution and associated risk factors. METHODS: Radiographic evidence of disease progression was evaluated for underground coal miners examined through US federal chest radiograph surveillance programmes from 1996 to 2002. A case of rapidly progressive CWP was defined as the development of PMF and/or an increase in small opacity profusion greater than one subcategory over five years. County based prevalences were derived for both CWP and rapidly progressive cases. RESULTS: A total of 886 cases of CWP were identified among 29 521 miners examined from 1996 to 2002. Among the subset of 783 miners with CWP for whom progression could be evaluated, 277 (35.4%) were cases of rapidly progressive CWP, including 41 with PMF. Miners with rapidly progressive CWP were younger than miners without rapid progression, were more likely to have worked in smaller mines (<50 employees), and also reported longer mean tenure in jobs involving work at the face of the mine (in contrast to other underground mining jobs), but did not differ with respect to mean underground tenure. There was a clear tendency for the proportion of cases of rapidly progressive CWP to be higher in eastern Kentucky, and western Virginia. CONCLUSIONS: Cases of rapidly progressive CWP can be regarded as sentinel health events, indicating inadequate prevention measures in specific regions. Such events should prompt investigations to identify causal factors and initiate appropriate additional measures to prevent further disease.
SN - 1351-0711
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS 2800, Morgantown, WV 26505; VAntao@cdc.gov
U2 - PMID: 16169911.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106397262
T1 - The precision of longitudinal lung function measurements: monitoring and interpretation.
AU - Hnizdo E
AU - Yu L
AU - Freyder L
AU - Attfield M
AU - Lefante J
AU - Glindmeyer HW
Y1 - 2005/10//
N1 - Accession Number: 106397262. Language: English. Entry Date: 20060217. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Lung Diseases -- Diagnosis
KW - Lung -- Physiopathology
KW - Occupational Diseases -- Diagnosis
KW - Decision Making
KW - Forced Expiratory Volume
KW - Lung Diseases -- Physiopathology
KW - Occupational Diseases -- Physiopathology
KW - Prospective Studies
KW - Sensitivity and Specificity
KW - Spirometry
KW - Human
SP - 695
EP - 701
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 62
IS - 10
PB - BMJ Publishing Group
AB - BACKGROUND: The efficacy of decision making based on longitudinal spirometric measurements depends critically on the precision of the available data, which is determined by the magnitude of the within-person variation. AIMS: Firstly, to describe and investigate two statistical methods-a pairwise estimate of within-person standard deviation s(p) and the reliability coefficient G-for use in the monitoring of precision of longitudinal measurements of forced expiratory volume in one second (FEV1). Secondly, to investigate the effect of longitudinal data precision on the detectable excess rate of decline in FEV1. METHODS: The authors 'monitored' retrospectively on a yearly basis the magnitude of the within-person variation s(p) and the coefficient G in 11 workplace based spirometric monitoring programmes conducted from 1987 to 2001 on 12 729 workers in various industrial plants. RESULTS: The plant-specific mean values s(p) (range 122-166 ml) and G (range 0.88-0.95), averaged over all years of follow up, correlated well with the plant-specific within-person standard deviation s(r) (range 130-177 ml) estimated from all longitudinal data. The correlations were 0.90 for s(p) and 0.68 for G. The average precision of the longitudinal FEV1 measurements affected the duration of follow up needed to identify a 'true' excess rate of decline in FEV1 in an individual. CONCLUSIONS: The results show that monitoring of longitudinal spirometry data precision (1) allows that data precision can be improved or maintained at levels that allow individuals with a rapid decline to be identified at an earlier age; and (2) attaches a measure of precision to the data on which decision making is based.
SN - 1351-0711
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; ehnizdo@cdc.gov
U2 - PMID: 16169915.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pendergrass, Stephanie M.
AU - Dollberg, Donald D.
T1 - NMAM Methods Update.
JO - Occupational Health & Safety
JF - Occupational Health & Safety
Y1 - 2005/10//
VL - 74
IS - 10
M3 - Article
SP - 38
EP - 92
SN - 03624064
AB - This article provides a general comparison of the new capillary column-based methods versus the original, outdated, and/or problematic packed column methods for air sampling and analytical method development. The methods identified and evaluated have incorporated the most recently available fused silica capillary column technology. By selection of alternative desorption solvents and improved or new solid sorbent media, combined with the improved resolution afforded by capillary column chromatography, the desorption efficiency was improved for each analyte evaluated at substantially lower concentrations. This method equip occupational and environmental hygienists with new/or improved procedures for the sampling of workplace hazards.
KW - Air analysis
KW - Industrial hygiene
KW - Chromatographic analysis
KW - Work environment
KW - Technological innovations
KW - Industrial engineering
N1 - Accession Number: 18532293; Pendergrass, Stephanie M. 1; Email Address: smp5@cdc.gov; Dollberg, Donald D. 2,3; Affiliations: 1: Senior Research Chemist and Biologist for NIOSH, Cincinnati, Ohio.; 2: Captain, Public Health Service, NIOSH, Cincinnati.; 3: Team Leader, Chemical Exposure Monitoring Branch, NIOSH, Cincinnati.; Issue Info: Oct2005, Vol. 74 Issue 10, p38; Thesaurus Term: Air analysis; Thesaurus Term: Industrial hygiene; Thesaurus Term: Chromatographic analysis; Subject Term: Work environment; Subject Term: Technological innovations; Subject Term: Industrial engineering; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wolff, George L.
AU - Whittaker, Paul
T1 - Dose–response effects of ectopic agouti protein on iron overload and age-associated aspects of the A vy /a obese mouse phenome
JO - Peptides
JF - Peptides
Y1 - 2005/10//
VL - 26
IS - 10
M3 - Article
SP - 1697
EP - 1711
SN - 01969781
AB - Abstract: Isogenic and congenic offspring from matings of inbred black a/a dams by sibling (or non-sibling from another inbred strain) yellow agouti A vy /a sires provide an animal model of obese yellow agouti A vy /a and isogenic lean pseudoagouti A vy /a mice exhibiting two different in vivo concentrations (high, very low) of ectopic agouti protein (ASP) with congenic lean black a/a mice as null controls. This makes it possible to differentiate between the high and very low dose levels of ectopic ASP with respect to interactions with diverse physiological and molecular pathways. Assay of differential responses to 12 or 24 months of carbonyl iron overload assessed the possible suitability of this animal model for the study of hemochromatosis. Agouti A/a B6C3F1 mice were used as non-congenic null controls. The age-related waxing and waning of body weight, food consumption, and caloric efficiency, as well as associated changes in pancreatic islets and islet cells, and formation of liver tumors were assayed. While the hypothesis that these mice might serve as a tool for investigating hemochromatosis was not confirmed, the data did provide evidence that even the very low levels of ASP in pseudoagouti A vy /a mice affect the network of molecular/metabolic/physiological response pathways that comprises the yellow agouti obese phenome. We suggest that the combination of yellow agouti A vy /a, pseudoagouti A vy /a, and black a/a congenic mice provides a practical tool for applying a dose–response systems biology approach to understanding the dysregulatory influence of ectopic ASP on the molecular-physiological matrix of the organism. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - HEMOCHROMATOSIS
KW - INBORN errors of metabolism
KW - ISLANDS of Langerhans
KW - Age-associated weight loss
KW - Agouti protein
KW - Caloric efficiency
KW - Hepatocellular tumors
KW - Hyperplasia
KW - Iron overload
KW - Melanocortin receptor 4
KW - Obesity
KW - Pancreatic islet cells
KW - Pseudoagouti mice
KW - Systems biology
N1 - Accession Number: 18341449; Wolff, George L. 1; Email Address: gwolffar@prodigy.net Whittaker, Paul 2; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA; Source Info: Oct2005, Vol. 26 Issue 10, p1697; Subject Term: MICE; Subject Term: HEMOCHROMATOSIS; Subject Term: INBORN errors of metabolism; Subject Term: ISLANDS of Langerhans; Author-Supplied Keyword: Age-associated weight loss; Author-Supplied Keyword: Agouti protein; Author-Supplied Keyword: Caloric efficiency; Author-Supplied Keyword: Hepatocellular tumors; Author-Supplied Keyword: Hyperplasia; Author-Supplied Keyword: Iron overload; Author-Supplied Keyword: Melanocortin receptor 4; Author-Supplied Keyword: Obesity; Author-Supplied Keyword: Pancreatic islet cells; Author-Supplied Keyword: Pseudoagouti mice; Author-Supplied Keyword: Systems biology; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.peptides.2004.12.033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pfister, William R.
AU - Ghosh, Tapash K.
T1 - Orally Disintegrating Tablets Products, Technologies, and Development Issues.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2005/10//
VL - 29
IS - 10
M3 - Article
SP - 136
EP - 150
PB - Advanstar Communications Inc.
SN - 15432521
AB - Focuses on orally disintegrating tablets and their manufacturing technologies, development issues and future trends. Comparison of orally disintegrating tablets with conventional sublingual tablets, lozenges and buccal tablets; Freeze-dried wafer; Quick dissolving tablet. INSET: Descriptions of orally disintegrating dosage forms..
KW - TABLETS (Medicine)
KW - SOLID dosage forms
KW - DRUGS
KW - BIOACTIVE compounds
KW - PHARMACOLOGY
N1 - Accession Number: 18567279; Pfister, William R. 1; Ghosh, Tapash K. 2; Affiliations: 1: Senior director of preclinical affairs, NexMed (USA), Inc., (Robbinsville, NJ); 2: Senior clinical pharmacology and biopharmaceutics reviewer, US Food and Drug Administration (HFD 880), 9201 Corporate Blvd., Room N224, Rockville, MD 20850; Issue Info: Oct2005, Vol. 29 Issue 10, p136; Subject Term: TABLETS (Medicine); Subject Term: SOLID dosage forms; Subject Term: DRUGS; Subject Term: BIOACTIVE compounds; Subject Term: PHARMACOLOGY; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Kirkland, Diane
AU - Wills, Wendy
T1 - Book reviews.
JO - Primary Health Care Research & Development (Sage Publications, Ltd.)
JF - Primary Health Care Research & Development (Sage Publications, Ltd.)
Y1 - 2005/10//
VL - 6
IS - 4
M3 - Book Review
SP - 367
EP - 369
PB - Sage Publications, Ltd.
SN - 14634236
AB - Reviews two books "The Ethics of Survivor Research. Guidelines for the Ethical Conduct of Research Carried Out by Mental Health Service Users and Survivors," by A. Faulkner and "Researchers and Their 'Subjects': Ethics, Power, Knowledge and Consent," edited by M. Smyth and E. Williamson.
KW - ETHICS
KW - NONFICTION
KW - FAULKNER, A.
KW - WILLIAMSON, E.
KW - SMYTH, M.
KW - ETHICS of Survivor Research: Guidelines for the Ethical Conduct of Research Carried out by Mental Health Service Users & Survivors, The (Book)
KW - RESEARCHERS & Their Subjects: Ethics, Power, Knowledge & Consent (Book)
N1 - Accession Number: 18407671; Kirkland, Diane 1 Wills, Wendy 2; Affiliation: 1: Senior Public Health Practitioner, National Public Health Service, Wales 2: Research Fellow in Child and Adolescent Health, CRIPACC, University of Hertfordshire; Source Info: Oct2005, Vol. 6 Issue 4, p367; Subject Term: ETHICS; Subject Term: NONFICTION; Reviews & Products: ETHICS of Survivor Research: Guidelines for the Ethical Conduct of Research Carried out by Mental Health Service Users & Survivors, The (Book); Reviews & Products: RESEARCHERS & Their Subjects: Ethics, Power, Knowledge & Consent (Book); People: FAULKNER, A.; People: WILLIAMSON, E.; People: SMYTH, M.; Number of Pages: 3p; Document Type: Book Review
L3 - 10.1191/1463423605pc258xx
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18407671&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104350069
T1 - Book reviews.
AU - Kirkland D
AU - Wills W
Y1 - 2005/10//
N1 - Accession Number: 104350069. Language: English. Entry Date: 20130809. Revision Date: 20150711. Publication Type: Journal Article; book review. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 100897390.
KW - Consent (Research)
KW - Health Services Research -- Ethical Issues
KW - Knowledge
KW - Mental Health Services -- Utilization
KW - Power
KW - Researcher-Subject Relations -- Ethical Issues
KW - Survivors
SP - 367
EP - 369
JO - Primary Health Care Research & Development (Sage Publications, Ltd.)
JF - Primary Health Care Research & Development (Sage Publications, Ltd.)
JA - PRIM HEALTH CARE RES DEV
VL - 6
IS - 4
CY -
PB - Sage Publications, Ltd.
SN - 1463-4236
AD - Senior Public Health Practitioner, National Public Health Service, Wales
DO - 10.1191/1463423605pc258xx
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Griffiths, S.
AU - Fone, D.
AU - Borg, A.
T1 - Bone densitometry: the influence of deprivation on access to care.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2005/10//
VL - 119
IS - 10
M3 - Article
SP - 870
EP - 874
SN - 00333506
AB - Presents a study on bone densitometry. Explanation on osteoporosis; Methods used in the study; Findings.
KW - BONE densitometry
KW - BONES -- Radiography
KW - OSTEOPOROSIS
KW - BONES -- Diseases
KW - MEDICAL research
KW - Equity
KW - Osteoporosis
KW - Socio-economic deprivation
N1 - Accession Number: 18531296; Griffiths, S. 1 Fone, D. 1,2; Email Address: foned@cf.ac.uk Borg, A. 3; Affiliation: 1: National Public Health Service for Wales, 36, Orchard Street, Swansea SAI 5AQ, UK 2: National Public Health Service for Wales, Mamhilad Part Estate, Pontypool, Gwent NP4 0YP, UK 3: Centre for Health Sciences Research, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK; Source Info: Oct2005, Vol. 119 Issue 10, p870; Subject Term: BONE densitometry; Subject Term: BONES -- Radiography; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Diseases; Subject Term: MEDICAL research; Author-Supplied Keyword: Equity; Author-Supplied Keyword: Osteoporosis; Author-Supplied Keyword: Socio-economic deprivation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1016/j.puhe.2005.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18531296&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104742173
T1 - Bone densitometry: the influence of deprivation on access to care.
AU - Griffiths, S
AU - Fone, D
AU - Borg, A
Y1 - 2005/10//
N1 - Accession Number: 104742173. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 0376507.
KW - Absorptiometry, Photon -- Utilization
KW - Bone and Bones -- Radiography
KW - Health Services Accessibility
KW - Osteoporosis -- Radiography
KW - Female
KW - Middle Age
KW - Social Class
KW - Wales
SP - 870
EP - 874
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 119
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service for Wales, 36, Orchard Street, Swansea SAI 5AQ, UK.
U2 - PMID: 16005480.
DO - 10.1016/j.puhe.2005.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104742173&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hojin Moon
AU - Hyun-Joo Kim
AU - Chen, James J.
AU - Kodell, Ralph L.
T1 - Model Averaging Using the Kullback Information Criterion in Estimating Effective Doses for Microbial Infection and Illness.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2005/10//
VL - 25
IS - 5
M3 - Article
SP - 1147
EP - 1159
PB - Wiley-Blackwell
SN - 02724332
AB - Since the National Food Safety Initiative of 1997, risk assessment has been an important issue in food safety areas. Microbial risk assessment is a systematic process for describing and quantifying a potential to cause adverse health effects associated with exposure to microorganisms. Various dose-response models for estimating microbial risks have been investigated. We have considered four two-parameter models and four three-parameter models in order to evaluate variability among the models for microbial risk assessment using infectivity and illness data from studies with human volunteers exposed to a variety of microbial pathogens. Model variability is measured in terms of estimated ED01s and ED10s, with the view that these effective dose levels correspond to the lower and upper limits of the 1% to 10% risk range generally recommended for establishing benchmark doses in risk assessment. Parameters of the statistical models are estimated using the maximum likelihood method. In this article a weighted average of effective dose estimates from eight two- and three-parameter dose-response models, with weights determined by the Kullback information criterion, is proposed to address model uncertainties in microbial risk assessment. The proposed procedures for incorporating model uncertainties and making inferences are illustrated with human infection/illness dose-response data sets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Food -- Safety measures
KW - Food handling
KW - Microorganisms
KW - Bacteria
KW - Pathogenic microorganisms
KW - Benchmark dose
KW - food safety
KW - Kullback information
KW - low-dose extrapolation
KW - model uncertainty
N1 - Accession Number: 18669153; Hojin Moon 1; Email Address: hmoon@nctr.fda.gov; Hyun-Joo Kim 2; Chen, James J. 1; Kodell, Ralph L. 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research,U.S. Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079, USA; 2: Division of Mathematics and Computer Science, Truman State University, 100 East Normal, Violette Hall 2226, Kirksville, MO 63501, USA; Issue Info: Oct2005, Vol. 25 Issue 5, p1147; Thesaurus Term: Risk assessment; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food handling; Thesaurus Term: Microorganisms; Thesaurus Term: Bacteria; Thesaurus Term: Pathogenic microorganisms; Author-Supplied Keyword: Benchmark dose; Author-Supplied Keyword: food safety; Author-Supplied Keyword: Kullback information; Author-Supplied Keyword: low-dose extrapolation; Author-Supplied Keyword: model uncertainty; Number of Pages: 13p; Illustrations: 13 Charts; Document Type: Article
L3 - 10.1111/j.1539-6924.2005.00676.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Veldhuijzen, Irene K.
AU - Van Bergen, Jan E. A. M.
AU - Götz, Hannelore M.
AU - Hoebe, Christian J. P. A.
AU - Morré, Servaas A.
AU - Richardus, Jan Hendrik
T1 - Reinfections, Persistent Infections, and New Infections After General Population Screening for Chiamydia trachomatis Infection in The Netherlands.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2005/10//
VL - 32
IS - 10
M3 - Article
SP - 599
EP - 604
SN - 01485717
AB - Objectives: The objectives of this study were to determine the rate of new infections and reinfections or persistent infections with Chlamydia trachomatis to define appropriate screening intervals and to identify risk factors for reinfection. Design: This was a cross-sectional study among a subsample of participants in a population-based screening. Setting: This study was conducted in urban and rural areas in The Netherlands. Participants: A total of 21,000 15- to 29-year-old women and men were invited for home-based urine testing. One year after the study, a subsample of 299 participants were offered retesting. Main Outcome Measures: The authors studied the rate of infection with C. trachomatis. Serovar determination was used to potentially discriminate between new infections and reinfections or persistent infections. Results: Nine C. trachomatis infections were found among 187 responders (4.8% confidence interval, 1.7-7.9). The prevalence was 10.4% (5 of 48) in previous positives and 2.9% (4 of 139) in negatives. Three of 5 repeatedly positive participants were infected with a different C. trachomatis serovar. Conclusions: Our study indicates that infected persons found in a systematic, population-based screening should be rescreened within 1 year. Optimal screening intervals still need to be determined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Diseases is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLAMYDIA infections
KW - CHLAMYDIA trachomatis
KW - CHLAMYDIA
KW - BACTERIAL diseases
KW - SEXUALLY transmitted diseases
KW - NETHERLANDS
N1 - Accession Number: 18518758; Veldhuijzen, Irene K. 1 Van Bergen, Jan E. A. M. 2,3; Email Address: jvanbergen@soaaids.nl Götz, Hannelore M. 1 Hoebe, Christian J. P. A. 4 Morré, Servaas A. 5 Richardus, Jan Hendrik 1,6; Affiliation: 1: Municipal Public Health Service, Rotterdam, The Netherlands 2: STI AIDS Netherlands, The Netherlands 3: Department of General Practice, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands 4: Municipal Public Health Service, Eastern South Limburg, The Netherlands 5: Laboratory of Immunogenetics, Section Immunogenetics of Infection Diseases, VU University Medical Center, Amsterdam, The Netherlands 6: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Source Info: Oct2005, Vol. 32 Issue 10, p599; Subject Term: CHLAMYDIA infections; Subject Term: CHLAMYDIA trachomatis; Subject Term: CHLAMYDIA; Subject Term: BACTERIAL diseases; Subject Term: SEXUALLY transmitted diseases; Subject Term: NETHERLANDS; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1097/01.olq0000179887.01141.c3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Göotz, Hannelore M.
AU - Hoebe, Christian J. P. A.
AU - Van Bergen, Jan E. A. M.
AU - Irene K. Veldhuijzen
AU - Broer, Jan
AU - De Groot, F.
AU - Verhooren, M. J. C.
AU - Van Schaik, D. T.
AU - Coenen, A. J. J.
AU - Richardus, Jan H.
T1 - Management of Chlamydia Cases and Their Partners: Results From a Home-Based Screening Program Organized by Municipal Publlc Health Services With Referral to Regular Health Care.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2005/10//
VL - 32
IS - 10
M3 - Article
SP - 625
EP - 629
SN - 01485717
AB - Background: We evaluated the management of Chlamydia trachomatis cases and partners found in a systematic home-based chlamydia screening project in the Netherlands among 15- to 29-year-old women and men, organized by the Municipal Public Health Services (MHS). Methods: Infected participants (165/8339 = 2%) were referred to regular curative services. The treating physician provided feedback on treatment and partner notification. Results: Including the effect of a reminder, the treatment rate of all index cases was 91% (150/165); among persons with non-Dutch ethnicity, 81% (25/31). The majority of cases (82%) consulted the general practitioner for treatment as opposed to sexually transmitted disease/ MHS clinics (18%). Eighty-five percent of cases were treated within 2 weeks. The confirmed treatment rate of partners in the last 6 months was 49% (86/176); 57% (81/141) for current versus 14% (5/35) for other partners. Patient referral was advised in an additional 18% (25/141) of current partners and in 9% (3/35) of other partners (potential treatment). Conclusion: Home-based chlamydia screening and treatment through regular treatment facilities has proven to be effective in the Netherlands. The necessity of a reminder to increase treatment rate and the lower treatment rate in non-Dutch high-risk groups deserve attention. Low confirmed treatment rate of current partners carries the potential of reinfection, and patient-delivered treatment should be expanded. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Diseases is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLAMYDIA infections
KW - SEXUALLY transmitted diseases
KW - COMMUNICABLE diseases
KW - PUBLIC health
KW - CHLAMYDIA trachomatis
KW - NETHERLANDS
N1 - Accession Number: 18518762; Göotz, Hannelore M. 1; Email Address: gotzh@ggd.rotterdam.nl Hoebe, Christian J. P. A. 2 Van Bergen, Jan E. A. M. 3 Irene K. Veldhuijzen 1 Broer, Jan 4 De Groot, F. 4 Verhooren, M. J. C. 5 Van Schaik, D. T. 3 Coenen, A. J. J. 3 Richardus, Jan H. 6; Affiliation: 1: Municipal Public Health Service, Rotterdam, The Netherlands 2: Municipal Public Health Service, Eastern South Limburg, Heerlen, The Netherlands 3: STI AIDS Netherlands, Amsterdam, The Netherlands 4: Municipal Public Health Service, Groningen, The Netherlands 5: Municipal Publlc Health Service Hart voor Brabant, Tilburg, The Netherlands 6: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Source Info: Oct2005, Vol. 32 Issue 10, p625; Subject Term: CHLAMYDIA infections; Subject Term: SEXUALLY transmitted diseases; Subject Term: COMMUNICABLE diseases; Subject Term: PUBLIC health; Subject Term: CHLAMYDIA trachomatis; Subject Term: NETHERLANDS; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1097/01.olq.0000175397.82962.d5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18518762&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106388911
T1 - Reinfections, persistent infections, and new infections after general population screening for chlamydia trachomatis infection in The Netherlands.
AU - Veldhuijzen IK
AU - van Bergen JEA
AU - Götz HM
AU - Hoebe CJP
AU - Morré SA
AU - Richardus JH
Y1 - 2005/10//
N1 - Accession Number: 106388911. Corporate Author: Pilot CT Study Group. Language: English. Entry Date: 20060127. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the Netherlands Organisation for Health Research and Development (ZonMw); Tramedico BV, The Netherlands; the Falk Foundation, Germany; the Department of Internal Medicine, VU University Medical Centre; and Foundation of Immunogenetics, Amsterdam, The Netherlands. NLM UID: 7705941.
KW - Chlamydia Infections -- Epidemiology
KW - Chlamydia Infections -- Prevention and Control
KW - Chlamydia Trachomatis
KW - Patient Compliance
KW - Urinalysis -- Utilization
KW - Adolescence
KW - Adult
KW - Chi Square Test
KW - Chlamydia Infections -- Etiology
KW - Chlamydia Infections -- Urine
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Effect Size
KW - Female
KW - Fisher's Exact Test
KW - Health Screening -- Methods
KW - Male
KW - Netherlands
KW - P-Value
KW - Prevalence
KW - Recurrence
KW - Retrospective Design
KW - Risk Factors
KW - Rural Health
KW - Self Administration
KW - Urban Health
KW - Funding Source
KW - Human
SP - 599
EP - 604
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 32
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Municipal Public Health Service, Rotterdam, The Netherlands
U2 - PMID: 16205300.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ferguson, Sherry A.
AU - Cisneros, F. Javier
AU - Gough, B.
AU - Hanig, Joseph P.
AU - Berry, Kimberly J.
T1 - Chronic Oral Treatment with 13-cis -Retinoic Acid (Isotretinoin) or all-trans -Retinoic Acid Does Not Alter Depression-Like Behaviors in Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/10//
VL - 87
IS - 2
M3 - Article
SP - 451
EP - 459
PB - Oxford University Press / USA
SN - 10966080
AB - Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression. Here, depression-like behaviors (i.e., behavioral despair and anhedonia) were quantified in adult Sprague-Dawley rats gavaged daily beginning at postnatal day (PND) 82 with 13-cis-RA (7.5 or 22.5 mg/kg) or all-trans-retinoic acid (10 or 15 mg/kg ). Tested at PND 130–131 in the Forced Swim Test, 7.5 mg/kg 13-cis-RA marginally decreased immobility and slightly increased climb/struggle durations whereas neither all-trans-retinoic acid group differed from controls. Voluntary saccharin solution (0.03%) intake at PND 102–104 and PND 151–153 was not different from controls in any treated group, although all RA-treated groups had lower intakes. Swim speed in a water maze at PND 180 was similar across groups, indicating no RA-induced differences in physical ability. Open field activity was mildly decreased at PND 91 in 7.5 mg/kg–treated males only, but it was within the control range at PND 119, 147, and 175. Thus, at serum levels similar to those in humans receiving the drug, chronic 13-cis-RA treatment did not severely affect depression-like behaviors in rats. These data do not substantiate the hypothesis of 13-cis-RA-induced depression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Isotretinoin
KW - Rats as laboratory animals
KW - Saccharin
KW - Anhedonia
KW - Tretinoin
KW - 13-cis-retinoic acid
KW - all-trans-retinoic acid
KW - anhedonia
KW - depression
KW - Forced Swim Test
KW - isotretinoin
KW - locomotor activity
N1 - Accession Number: 20605996; Ferguson, Sherry A. 1; Email Address: sferguson@nctr.fda.gov; Cisneros, F. Javier 1; Gough, B. 1; Hanig, Joseph P. 2; Berry, Kimberly J. 1; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkasas 72079; 2: Center for Drug Evaluation Research/U.S. Food and Drug Administration, Silver Spring, Maryland; Issue Info: Oct2005, Vol. 87 Issue 2, p451; Subject Term: Isotretinoin; Subject Term: Rats as laboratory animals; Subject Term: Saccharin; Subject Term: Anhedonia; Subject Term: Tretinoin; Author-Supplied Keyword: 13-cis-retinoic acid; Author-Supplied Keyword: all-trans-retinoic acid; Author-Supplied Keyword: anhedonia; Author-Supplied Keyword: depression; Author-Supplied Keyword: Forced Swim Test; Author-Supplied Keyword: isotretinoin; Author-Supplied Keyword: locomotor activity; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/toxsci/kfi262
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sander, Miriam
AU - Cadet, Jean
AU - Casciano, Daniel A.
AU - Galloway, Sheila M.
AU - Marnett, Lawrence J.
AU - Novak, Raymond F.
AU - Pettit, Syril D.
AU - Preston, R. Julian
AU - Skare, Julie A.
AU - Williams, Gary M.
AU - Van Houten, Bennett
AU - Gollapudi, B. Bhaskar
T1 - Proceedings of a workshop on DNA adducts: Biological significance and applications to risk assessment Washington, DC, April 13–14, 2004
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2005/10//
VL - 208
IS - 1
M3 - Article
SP - 1
EP - 20
SN - 0041008X
AB - Abstract: In April 2004, the Health and Environmental Sciences Institute, a branch of the International Life Sciences Institute, with support from the National Institute of Environmental Health Sciences, organized a workshop to discuss the biological significance of DNA adducts. Workshop speakers and attendees included leading international experts from government, academia, and industry in the field of adduct detection and interpretation. The workshop initially examined the relationship between measured adduct levels in the context of exposure and dose. This was followed by a discussion on the complex response of cells to deal with genotoxic insult in complex, interconnected, and interdependent repair pathways. One of the major objectives of the workshop was to address the recurring question about the mechanistic and toxicological relevance of low-concentration measured adducts and the presentations in the session entitled “Can low levels of DNA adducts predict adverse outcomes?” served as catalysts for further discussions on this subject during the course of the workshop. Speakers representing the regulatory community and industry reviewed the value, current practices, and limitations of utilizing DNA adduct data in risk assessment and addressed a number of practical questions pertaining to these issues. While no consensus statement emerged on the biological significance of low levels of DNA adducts, the workshop concluded by identifying the need for more experimental data to address this important question. One of the recommendations stemming from this workshop was the need to develop an interim “decision-logic” or framework to guide the integration of DNA adduct data in the risk assessment process. HESI has recently formed a subcommittee consisting of experts in the field and other key stakeholders to address this recommendation as well as to identify specific research projects that could help advance the understanding of the biological significance of low levels of DNA adducts. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - Genes
KW - Investment analysis
KW - Science
KW - DNA
KW - DNA adducts
KW - DNA damage
KW - Risk assessment
KW - Workshop report
N1 - Accession Number: 18307359; Sander, Miriam 1; Cadet, Jean 2; Casciano, Daniel A. 3; Galloway, Sheila M. 4; Marnett, Lawrence J. 5; Novak, Raymond F. 6; Pettit, Syril D. 7; Email Address: spettit@ilsi.org; Preston, R. Julian 8; Skare, Julie A. 9; Williams, Gary M. 10; Van Houten, Bennett 11; Gollapudi, B. Bhaskar 12; Affiliations: 1: Page One Editorial Services, Durham, NC 27707, USA; 2: The French Atomic Energy Commission, 38054 Grenoble, France; 3: National Center for Toxicological Research, Jefferson, AR 72079, USA; 4: Merck Research Laboratories, West Point, PA 19486, USA; 5: Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37235, USA; 6: Institute of Chemical Toxicology, Wayne State University, Detroit, MI 48201, USA; 7: ILSI Health and Environmental Sciences Institute, One Thomas Circle, 9th Floor, NW, Washington, DC 20005, USA; 8: U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA; 9: Central Product Safety, The Procter and Gamble Company, Cincinnati, OH 45217, USA; 10: Department of Pathology and Toxicology, New York Medical College, Valhalla, NY 10595, USA; 11: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; 12: Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA; Issue Info: Oct2005, Vol. 208 Issue 1, p1; Thesaurus Term: Nucleic acids; Subject Term: Genes; Subject Term: Investment analysis; Subject Term: Science; Author-Supplied Keyword: DNA; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Workshop report; Number of Pages: 20p; Document Type: Article
L3 - 10.1016/j.taap.2004.12.012
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2005-06565-001
AN - 2005-06565-001
AU - Duffy, Farifteh Firoozmand
AU - Narrow, William
AU - West, Joyce C.
AU - Fochtmann, Laura J.
AU - Kahn, David A.
AU - Suppes, Trisha
AU - Oldham, John M.
AU - Mclntyre, John S.
AU - Manderscheid, Ronald W.
AU - Sirovatka, Paul
AU - Regier, Darrel
T1 - Quality of Care Measures for the Treatment of Bipolar Disorder.
JF - Psychiatric Quarterly
JO - Psychiatric Quarterly
JA - Psychiatr Q
Y1 - 2005/10//
VL - 76
IS - 3
SP - 213
EP - 230
CY - Germany
PB - Springer
SN - 0033-2720
SN - 1573-6709
AD - Duffy, Farifteh Firoozmand, American Psychiatric Institute for Research and Education, Education, 1000 Wilson Blvd, Suite 1825, Arlington, VA, US, 22209
N1 - Accession Number: 2005-06565-001. PMID: 16080418 Partial author list: First Author & Affiliation: Duffy, Farifteh Firoozmand; American Psychiatric Institute for Research and Education, Arlington, VA, US. Release Date: 20050711. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Quality of Care; Treatment Effectiveness Evaluation; Treatment Guidelines. Minor Descriptor: Drug Therapy; Psychotherapy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 18. Issue Publication Date: Oct, 2005.
AB - The staff of the American Psychiatric Assocition (APA), the American Psychiatric Institute for Research and Education (APIRE), and a national panel of experts in bipolar disorder and practice guideline development have collaborated to generate a set of quality of care indicators for the pharmacologic and psychosocial treatment of bipolar disorder. The indicators were derived from APA's evidence-based Practice Guideline for the Treatment of Patients with Bipolar Disorder, 2002 (1) and the Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder, 2000 (2) These quality indicators can be used for quality monitoring, benchmarking, and quality improvement efforts across health plans, systems of care, and health care providers to improve quality and outcomes of care for patients with bipolar disorder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bipolar disorder
KW - quality indicators
KW - quality of care measures
KW - pharmacological treatment
KW - practice guidelines
KW - psychosocial treatment
KW - 2005
KW - Bipolar Disorder
KW - Quality of Care
KW - Treatment Effectiveness Evaluation
KW - Treatment Guidelines
KW - Drug Therapy
KW - Psychotherapy
KW - 2005
DO - 10.1007/s11126-005-2975-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-06565-001&site=ehost-live&scope=site
UR - fduffy@psych.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13992-005
AN - 2005-13992-005
AU - Hinden, Beth R.
AU - Biebel, Kathleen
AU - Nicholson, Joanne
AU - Mehnert, Liz
T1 - The Invisible Children's Project: Key Ingredients of an Intervention for Parents With Mental Illness.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2005/10//Oct-Dec, 2005
VL - 32
IS - 4
SP - 393
EP - 408
CY - US
PB - National Council for Community Behavioral Healthcare (NCCBH)
SN - 1094-3412
AD - Hinden, Beth R., Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA, US, 01655
N1 - Accession Number: 2005-13992-005. PMID: 16215449 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Hinden, Beth R.; Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Springer. Release Date: 20060103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Intervention; Mental Disorders; Parental Attitudes; Parents. Minor Descriptor: Family. Classification: Psychological Disorders (3210). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Clinical Case Study; Empirical Study; Qualitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Oct-Dec, 2005.
AB - This study used a collective case study design to identify key ingredients of the Invisible Children's Project, an intervention program for families in which a parent has a mental illness. Data were obtained from interviews with parents and service providers, and from family file records. Qualitative analyses were used to generate hypotheses regarding key ingredients and targeted outcomes, and to develop a testable intervention model. Key ingredients were defined as core processes, essential services, and mediators. Strong convergence across parents and providers suggested core processes defined by family-centered, strengths-based, emotionally supportive, and comprehensive approaches; essential services including family case management, 24-hour crisis services, access to flexible funds, liaison and advocacy, and mediators reflecting parent-provider trust and communication/ cooperation, provider-provider trust, adoption of strengths-based approaches, development of appropriate treatment plans, parent engagement, and parent self-esteem/self-efficacy. A model of the intervention is presented, and results are discussed with respect to research and policy implications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intervention program
KW - mental illness
KW - service providers
KW - parental attitudes
KW - Invisible Childrens Project
KW - 2005
KW - Intervention
KW - Mental Disorders
KW - Parental Attitudes
KW - Parents
KW - Family
KW - 2005
DO - 10.1007/BF02384200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13992-005&site=ehost-live&scope=site
UR - bhinden@rcn.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13265-009
AN - 2005-13265-009
AU - Ward, Michael M.
AU - Weisman, Michael H.
AU - Davis, John C. Jr.
AU - Reveille, John D.
T1 - Risk Factors For Functional Limitations in Patients With Long-Standing Ankylosing Spondylitis.
JF - Arthritis & Rheumatism: Arthritis Care & Research
JO - Arthritis & Rheumatism: Arthritis Care & Research
JA - Arthritis Rheum
Y1 - 2005/10//
VL - 53
IS - 5
SP - 710
EP - 717
CY - US
PB - John Wiley & Sons
SN - 0004-3591
SN - 1529-0131
AD - Ward, Michael M., NIH/NIAMS/IRP, Building 10 CRC. Room 4-1339, 10 Center Drive, MSC 1468, Bethesda, MD, US, 20892-1468
N1 - Accession Number: 2005-13265-009. PMID: 16208654 Other Journal Title: Arthritis Care & Research. Partial author list: First Author & Affiliation: Ward, Michael M.; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Joint Disorders; Medical Patients; Risk Factors. Minor Descriptor: Disease Course. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Bath Ankylosing Spondylitis Functional Index; Health Assessment Questionnaire for the Spondylarthropathies. Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2005.
AB - Objective: To identify risk factors for functional limitations in patients with ankylosing spondylitis (AS) of at least 20 years' duration. Methods: Patients with AS for ≥20 years were enrolled in the cross-sectional component of the Prospective Study of Outcomes in AS. All patients had clinical evaluations and completed questionnaires on functional limitations and potential risk factors. Functional limitations were assessed using the Bath Ankylosing Spondylitis Functional Index (BASFI; score range 0-100, higher scores indicate more limitations) and the Health Assessment Questionnaire for the Spondylarthropathies (HAQS). Risk factors included demographic characteristics, duration of AS, smoking status, number of comorbid medical conditions, recalled level of recreational activity in teens and twenties, occupational physical activity throughout life (rated 1 = little, 2 = moderate, 3 = heavy, and weighted by the number of years in each job), and history of AS in a first-degree relative. Results: The 326 patients (74% men) had a mean ± SD age of 55.0 ± 10.7 years, a mean duration of AS symptoms of 31.7 ± 10.2 years, and a mean BASFI score of 40.7 ± 25.6. BASFI scores increased with higher lifetime occupational physical activity (r = 0.31; P < 0.0001), the number of comorbid conditions (r = 0.25; P < 0.0001), and the duration of AS (r = 0.12; P = 0.04). BASFI scores were higher among current smokers compared with former/nonsmokers (55.5 versus 38.9; P = 0.0002), and among nonwhites compared with whites (49.9 versus 39.3; P = 0.02). In multivariable analyses, lifetime occupational physical activity, current smoking, education level, number of comorbid conditions, and family history were significantly associated with BASFI scores. The same risk factors were associated with the HAQS. Conclusion: Functional limitations in patients with AS for ≥20 years are greater among those with a history of more physically demanding jobs, more comorbid conditions, and among smokers, and are less severe among those with higher levels of education and a family history of AS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk factors
KW - patients
KW - ankylosing spondylitis
KW - 2005
KW - Client Characteristics
KW - Joint Disorders
KW - Medical Patients
KW - Risk Factors
KW - Disease Course
KW - 2005
U1 - Sponsor: US Public Health Service. Grant: AR-48465; AR-46208; M01-RR000079; M01-RR02558; M01-RR00425. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Intramural Research Program. Recipients: No recipient indicated
DO - 10.1002/art.21444
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13265-009&site=ehost-live&scope=site
UR - wardm1@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-12159-002
AN - 2005-12159-002
AU - Lockhart, Tamara L.
AU - Jamieson, Christopher P.
AU - Steinman, Alan M.
AU - Giesbrecht, Gordon G.
T1 - Life Jacket Design Affects Dorsal Head and Chest Exposure, Core Cooling, and Cognition in 10°C Water.
JF - Aviation, Space, and Environmental Medicine
JO - Aviation, Space, and Environmental Medicine
JA - Aviat Space Environ Med
Y1 - 2005/10//
VL - 76
IS - 10
SP - 954
EP - 962
CY - US
PB - Aerospace Medical Assn
SN - 0095-6562
AD - Giesbrecht, Gordon G., University of Manitoba, 211 Max Bell Centre, Winnipeg, Canada, R3T 2N2
N1 - Accession Number: 2005-12159-002. PMID: 16235879 Other Journal Title: Aerospace Medicine; Aerospace Medicine and Human Performance. Partial author list: First Author & Affiliation: Lockhart, Tamara L.; Laboratory for Exercise and Environmental Medicine, Health, Leisure and Human Performance Research Institute, University of Manitoba, Winnipeg, MB, Canada. Release Date: 20060327. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognition; Head (Anatomy); Performance; Safety Devices; Temperature Effects. Classification: Engineering & Environmental Psychology (4000). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Tests of Mental Performance; Cold Sensation and Physical Soreness Scale; Logic Reasoning Test; Stroop Word-Color Test; Digit Symbol Coding; Backward Digit Span; Paced Auditory Serial Addition Test. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 2005.
AB - Purpose: Personal floatation devices (PFDs) differ in whether they maintain the head out of the water or allow the dorsum of the head to be immersed. Partial head submersion may hasten systemic cooling, incapacitation, and death in cold water. Methods: Six healthy male volunteers (mean age = 26.8 yr; height = 184 cm; weight = 81 kg; body fat = 20%) were immersed in 10°C water for 65 min, or until core temperature = 34°C, under three conditions: PFD#1 maintained the head and upper chest out of the water; PFD#2 allowed the dorsal head and whole body to be immersed; and an insulated drysuit (control) allowed the dorsal head to be immersed. Mental performance tests included: logic reasoning test; Stroop word-color test; digit symbol coding; backward digit span; and paced auditory serial addition test (PASAT). Results: Core cooling was significantly faster for PFD#2 (2.8 ± 1.6°C • h-1) than for PFD#1 (1.5 ± 0.7°C • h-1) or for the drysuit (0.4 ± 0.2°C • h-1). Although no statistically significant effects on cognitive performance were noted for the individual PFDs and drysuit, when analyzed as a group, four of the tests of cognitive performance (Stroop word-color, digit symbol coding, backward digit span, and PASAT) showed significant correlations between decreasing core temperature to 34°C and diminished cognitive performance. Conclusions: Performance in more complicated mental tasks was adversely affected as core temperature decreased to 34°C. The PFD that kept the head and upper chest out of the water preserved body heat and mental performance better than the PFD that produced horizontal flotation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - life jacket design
KW - dorsal head exposure
KW - chest exposure
KW - core cooling
KW - cognition
KW - water temperature
KW - personal floatation devices
KW - mental tasks
KW - core temperature
KW - mental performance
KW - 2005
KW - Cognition
KW - Head (Anatomy)
KW - Performance
KW - Safety Devices
KW - Temperature Effects
KW - 2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12159-002&site=ehost-live&scope=site
UR - giesbrec@ms.umanitoba.ca
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-12573-020
AN - 2005-12573-020
AU - Curie, Charles G.
AU - Geller, Jeffrey L.
ED - Geller, Jeffrey L.
T1 - 'Doctor's standing orders'.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/10//
VL - 56
IS - 10
SP - 1203
EP - 1204
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Curie, Charles G., 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2005-12573-020. PMID: 16215185 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Curie, Charles G.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060522. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Kidneys; Recovery (Disorders); Surgery. Minor Descriptor: Hospitals; Treatment Duration. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 2005.
AB - I was admitted to a hospital to undergo surgery for a kidney stone. Throughout most of my hospital stay I received excellent care from the entire medical team assembled around me to oversee my treatment and to help facilitate my recovery. After surgery I worked diligently as a partner in my own recovery to speed up my healing by following the guidance of my physicians and nurses. On the day I was to be discharged a nurse came into my room before dawn and announced that she was going to 'flush out' my healing kidney with a saline solution. The nurse assured me that she had to perform the procedure and that it was 'doctor's standing orders.' Later the same day, after the nurse had gone, my doctor came to check on me, expecting to find my condition much improved. He was livid when he discovered what had happened and explained that the procedure was certainly not among his standing orders. A mistake had been made, and my confidence in the hospital and its staff vaporized. I can say with clarity now that the experience helped me gain a deeper, much more personal understanding of what it may mean to mental health consumers who have endured the practices of seclusion and restraint. At the same time, I realize that this issue is not about me, and I realize that my story pales in comparison with the stories that have been told by consumers, families, and advocates. I am blessed because I am healing and will recover. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - standing orders
KW - kidney stone
KW - hospital stay
KW - surgery
KW - recovery
KW - seclusion
KW - 2005
KW - Kidneys
KW - Recovery (Disorders)
KW - Surgery
KW - Hospitals
KW - Treatment Duration
KW - 2005
DO - 10.1176/appi.ps.56.10.1203
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12573-020&site=ehost-live&scope=site
UR - Charles.curie@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-12573-005
AN - 2005-12573-005
AU - Leff, H. Stephen
AU - Cook, Judith A.
AU - Gold, Paul B.
AU - Toprac, Marcia
AU - Blyler, Crystal
AU - Goldberg, Richard W.
AU - McFarlane, William
AU - Shafer, Michael
AU - Allen, I. Elaine
AU - Camacho-Gonsalves, Teresita
AU - Raab, Barbara
T1 - Effects of job development and job support on competitive employment of persons with severe mental illness.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/10//
VL - 56
IS - 10
SP - 1237
EP - 1244
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Leff, H. Stephen, Human Services Research Institute, 2269 Massachusetts Avenue, Cambridge, MA, US, 02140
N1 - Accession Number: 2005-12573-005. PMID: 16215189 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Leff, H. Stephen; Human Services Research Institute, Cambridge, MA, US. Release Date: 20060522. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Mental Disorders; Supported Employment; Vocational Rehabilitation. Minor Descriptor: Job Performance. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Followup Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2005.
AB - Objectives: Few studies have sought to determine which specific supported employment services improve employment outcomes for people with pyschiatric disabilities. This study examined the effects of job development and job support among other services on acquisition and retention of competitive employment. Methods: Data used in the analysis came from seven sites of the Employment Intervention Demonstration Program. Employment data were collected weekly for a period up to 24 months for 1,340 participants. A random-effects meta-analysis was conducted. Results: Job development increased the probability of obtaining competitive employment. The effects of job development on job acquisition remained after the effects of other factors were controlled for. Job support was associated with more months in the first competitive job but not total hours worked. However, no evidence for the causal role of job support was found in analyses that tested the effects of job support after the job support was provided. The causal role of job support alone was also cast in doubt by the fact that a substantial overlap existed between individuals who received job support and vocational counseling. Conclusions: Job development is a very effective service when the goal is job acquisition. Job support is associated with retention of a first competitive job, but its causal role is questionable. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job support
KW - job development
KW - competitive employment
KW - severe mental illness
KW - 2005
KW - Employment Status
KW - Mental Disorders
KW - Supported Employment
KW - Vocational Rehabilitation
KW - Job Performance
KW - 2005
DO - 10.1176/appi.ps.56.10.1237
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-12573-005&site=ehost-live&scope=site
UR - sleff@hsri.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-11767-005
AN - 2005-11767-005
AU - Pogorzelski, Wendy
AU - Wolff, Nancy
AU - Pan, Ko-Yu
AU - Blitz, Cynthia L.
T1 - Behavioral Health Problems, Ex-Offender Reentry Policies, and the 'Second Chance Act'.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2005/10//
VL - 95
IS - 10
SP - 1718
EP - 1724
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Pogorzelski, Wendy, Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2005-11767-005. PMID: 16131635 Partial author list: First Author & Affiliation: Pogorzelski, Wendy; Center for Mental Health Services Research & Criminal Justice Research, State University of New Jersey, New Brunswick, NJ, US. Release Date: 20060320. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Behavior; Criminals; Health; Mental Disorders; Prisons. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2005.
AB - The federal 'Second Chance Act of 2005' calls for expanding reentry services for people leaving prison, yet existing policies restrict access to needed services for those with criminal records. We examined the interaction between individual-level characteristics and policy-level restrictions related to criminal conviction, and the likely effects on access to resources upon reentry, using a sample of prisoners with Axis I mental disorders (n=3073).We identified multiple challenges related to convictions, including restricted access to housing, public assistance, and other resources. Invisible punishments embedded within existing policies were inconsistent with the call for second chances. Without modification of federal and state policies, the ability of reentry services to foster behavioral health and community reintegration is limited. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Second Chance Act
KW - ex-offenders
KW - reentry policies
KW - resources access
KW - criminal conviction
KW - behavioral health problems
KW - mental disorders
KW - 2005
KW - Criminal Behavior
KW - Criminals
KW - Health
KW - Mental Disorders
KW - Prisons
KW - 2005
DO - 10.2105/AJPH.2005.065805
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11767-005&site=ehost-live&scope=site
UR - wpogorzelski@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-11767-007
AN - 2005-11767-007
AU - Blitz, Cynthia L.
AU - Wolff, Nancy
AU - Pan, Ko-Yu
AU - Pogorzelski, Wendy
T1 - Gender-Specific Behavioral Health and Community Release Patterns Among New Jersey Prison Inmates: Implications for Treatment and Community Reentry.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2005/10//
VL - 95
IS - 10
SP - 1741
EP - 1746
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Blitz, Cynthia L., Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2005-11767-007. PMID: 16131640 Partial author list: First Author & Affiliation: Blitz, Cynthia L.; Center for Mental Health Services, Criminal Justice Research at Rutgers University, New Brunswick, NJ, US. Release Date: 20060320. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Rehabilitation; Diagnosis; Health; Prisoners; Special Needs. Minor Descriptor: Communities; Human Sex Differences; Mental Disorders; Prisons. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2005.
AB - Objectives: We describe behavioral health diagnoses and community release patterns among adult male and female inmates in New Jersey prisons and assess their implications for correctional health care and community reentry. Methods: We used clinical and classification data on a census of 'special needs' inmates (those with behavioral health disorders) in New Jersey (n=3189) and a census of all special needs inmates released to New Jersey communities over a 12-month period (n=974). Results: Virtually all adult inmates with special needs had at least 1 Axis I mental disorder, and 68% of these had at least 1 additional Axis I mental disorder, a personality disorder, or addiction problem (67% of all male and 75% of all female special needs inmates). Of those special needs inmates released, 25% returned to the most disadvantaged counties in New Jersey (27% of all male and 18% of all female special needs inmates). Conclusions: Two types of clustering were found: gender-specific clustering of disorders among inmates and spatial clustering of ex-offenders in impoverished communities. These findings suggest a need for gendered treatment strategies within correctional settings and need for successful reentry strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community reentry
KW - treatment implications
KW - prison inmates
KW - community release
KW - gender-specific behavioral health
KW - health diagnosis
KW - special needs inmates
KW - 2005
KW - Criminal Rehabilitation
KW - Diagnosis
KW - Health
KW - Prisoners
KW - Special Needs
KW - Communities
KW - Human Sex Differences
KW - Mental Disorders
KW - Prisons
KW - 2005
DO - 10.2105/AJPH.2004.059733
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11767-007&site=ehost-live&scope=site
UR - cblitz@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13468-003
AN - 2005-13468-003
AU - Gusev, Pavel A.
AU - Cui, Changhai
AU - Alkon, Daniel L.
AU - Gubin, Alexander N.
T1 - Topography of Arc/Arg3.1 mRNA Expression in the Dorsal and Ventral Hippocampus Induced by Recent and Remote Spatial Memory Recall: Dissociation of CA3 and CA1 Activation.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2005/10//
VL - 25
IS - 41
SP - 9384
EP - 9397
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Gusev, Pavel A., Blanchette Rockefeller Neuroiciences Institute, 9601 Medical Center Drive, Academic and Research Building, Room 316, Rockville, MD, US, 20850-3332
N1 - Accession Number: 2005-13468-003. PMID: 16221847 Partial author list: First Author & Affiliation: Gusev, Pavel A.; Blanchette Rockefeller Neurosciences Institute, Rockville, MD, US. Release Date: 20060213. Correction Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hippocampus; Neural Plasticity; Ribonucleic Acid; Spatial Memory; Topography. Minor Descriptor: Biological Markers; Corticosterone; Stress. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Oct, 2005.
AB - The understanding of the mechanisms of memory retrieval and its deficits, and the detection of memory underlying neuronal plasticity, is greatly impeded by a lack of precise knowledge of the brain circuitry that underlies the functions of memory. The specific roles of anatomically distinct hippocampal subdivisions in recent and long-term memory retention and recall are essentially unknown. To address these questions, we mapped the expression of Arc/Arg 3.1 mRNA, a neuronal activity marker, in memory retention at multiple rostrocaudal levels of the dentate gyrus, CA3, CA1, subiculum, and lateral and medial entorhinal cortices after a platform search in a water-maze spatial task at 24 h and 1 month compared with swim and naive controls. We found that the entorhinohippocampal neuronal activity underlying the recall of recent and remote spatial memory has an anatomically distributed and time-dependent organization throughout both the dorsal and ventral hippocampus that is subdivision specific. We found a dissociation in the activity of the entorhinal cortex, CA3, and CA1 over a period of memory consolidation. Although CA3, the dorsal hippocampus, and the entorhinal cortex demonstrated the most persistent learning-specific signal during both recent and long-term memory recall, CA1 and the ventral hippocampus displayed the most dramatic signal decline. We determined the coordinates of activity clusters in the hippocampal subdivisions during the platform search and their dynamics over time. Our mapping data suggest that although the level of corticohippocampal interaction is similar during the retrieval of recent and remote spatial memories, the mnemonic function of the hippocampus may have changed, and the activity underlying remote spatial memory could be anatomically segregated within hippocampal subdivisions in small segments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - topography
KW - RNA expression
KW - spatial memory
KW - hippocampus
KW - biological marker
KW - memory recall
KW - neuronal plasticity
KW - stress
KW - corticosterone
KW - 2005
KW - Hippocampus
KW - Neural Plasticity
KW - Ribonucleic Acid
KW - Spatial Memory
KW - Topography
KW - Biological Markers
KW - Corticosterone
KW - Stress
KW - 2005
DO - 10.1523/JNEUROSCI.0832-05.2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13468-003&site=ehost-live&scope=site
UR - gusevpa@brni-jhu.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Amat, Albert
AU - Rigau, Josepa
AU - Waynant, Ronald W.
AU - Ilev, Ilko K.
AU - Tomas, Josep
AU - Anders, Juanita J.
T1 - Modification of the intrinsic fluorescence and the biochemical behavior of ATP after irradiation with visible and near-infrared laser light
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2005/10/03/
VL - 81
IS - 1
M3 - Article
SP - 26
EP - 32
SN - 10111344
AB - Abstract: In this work, the effects of visible (655nm) and near-infrared (830nm) light on ATP in solution were examined. The addition of irradiated ATP to the hexokinase reaction caused significant differences in the reaction rates and in the Michaelis–Menten kinetic parameters, k m and v max. Irradiated ATP cleavage by hexokinase occurred in less time. Changes were wavelength and dose dependent. Excitation of ATP with a 260nm wavelength ultraviolet light induced a fluorescence emission that was decreased when Mg2+ was added due to ion binding of the phosphates, which are the structures that modify the fluorescence produced by the adenine dipoles. The irradiation of this ATP·Mg2+ solution using 655 and 830nm light increased the fluorescence by a possible displacement of Mg2+ from the phosphates. In conclusion, visible and near-infrared light modifies the biochemical behavior of ATP in the hexokinase reaction and the fluorescence intensity of the molecule thus altering the Mg2+ binding strength to the oxygen atoms in the phosphate group. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology B: Biology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOSINE triphosphate
KW - FLUORESCENCE
KW - BIOFLUORESCENCE
KW - CHEMICAL kinetics
KW - ATP
KW - Fluorescence
KW - Hexokinase
KW - Laser
KW - Michaelis–Menten enzymatic kinetics
N1 - Accession Number: 18343295; Amat, Albert 1,2,3; Email Address: albert.amat@urv.net Rigau, Josepa 1 Waynant, Ronald W. 2 Ilev, Ilko K. 2 Tomas, Josep 1 Anders, Juanita J. 3; Affiliation: 1: Histology and Neurobiology Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, c. Sant Llorenç 21, 43201 Reus, Spain 2: Division of Physics, Centre for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, Rockville, MD 20857, United States 3: Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States; Source Info: Oct2005, Vol. 81 Issue 1, p26; Subject Term: ADENOSINE triphosphate; Subject Term: FLUORESCENCE; Subject Term: BIOFLUORESCENCE; Subject Term: CHEMICAL kinetics; Author-Supplied Keyword: ATP; Author-Supplied Keyword: Fluorescence; Author-Supplied Keyword: Hexokinase; Author-Supplied Keyword: Laser; Author-Supplied Keyword: Michaelis–Menten enzymatic kinetics; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jphotobiol.2005.05.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18343295&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jihee Lee Kang
AU - Hye Won Lee
AU - Hee Jae Kim
AU - Hui Su Lee
AU - Castranova, Vincent
AU - Chae-Man Lim
AU - Younsuck Koh
T1 - Inhibition of SRC Tyrosine Kinases Suppresses Activation of Nuclear Factor-κB, and Serine and Tyrosine Phosphorylation of IκB-α in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/10/08/
VL - 68
IS - 19
M3 - Article
SP - 1643
EP - 1662
SN - 15287394
AB - Involvement of protein tyrosine kinases (PTK) in lipopolysaccharide (LPS)-induced nuclear factor-kappa B (NF-κB) activation has been demonstrated. Studies investigated the role of PTK and the underlying mechanisms by which PTK play a role in LPS induction of pathways leading to NF-κB activation in macrophages. Inhibitors of PTK—genistein, herbimycin A, or AG126—blocked LPS-induced NF-κB activation. Genistein also blocked pervanadate-induced NF-κB activation. Furthermore, Src TK selective inhibitors—damnacanthal or PP1—blocked LPS-induced NF-κB activation over a range of nanomolar concentrations. Genistein, damnacanthal, or PP1 blocked the LPS-induced serine phosphorylation, the degradation of IκB-α, and the consequent translocation of the p65 subunit of NF-κB to the nucleus. In addition to serine phosphorylation of IκB-α, LPS-induced NF-κB activation also required tyrosine phosphorylation of IκB-α. These TK inhibitors blocked substantially LPS induction of tyrosine phosphorylation of IκB-α. Furthermore, cSrc and Lck were physically associated with IκB-α. These results suggest that the LPS-induced NF-κB pathways are dependent on both serine and tyrosine phosphorylation of IκB-α, and that Src TK, such as cSrc and Lck, are key components of the LPS signaling pathway through at least two different mechanisms associated with NF-κB activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR toxicology
KW - TOXICOLOGICAL chemistry
KW - TOXICOLOGY
KW - ENVIRONMENTAL health
KW - TYROSINE
KW - CHEMICAL reactions
KW - NF-kappa B (DNA-binding protein)
N1 - Accession Number: 18405910; Jihee Lee Kang 1; Email Address: jihee@ewha.ac.kr Hye Won Lee 1 Hee Jae Kim 1 Hui Su Lee 1 Castranova, Vincent 2 Chae-Man Lim 3 Younsuck Koh 3; Affiliation: 1: Department of Physiology, College of Medicine, Division of Cell Biology, Ewha Medical Research Center, Ewha Womans University, Seoul, Korea 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Source Info: 2005, Vol. 68 Issue 19, p1643; Subject Term: MOLECULAR toxicology; Subject Term: TOXICOLOGICAL chemistry; Subject Term: TOXICOLOGY; Subject Term: ENVIRONMENTAL health; Subject Term: TYROSINE; Subject Term: CHEMICAL reactions; Subject Term: NF-kappa B (DNA-binding protein); Number of Pages: 20p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1080/15287390500192114
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18405910&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106290866
T1 - Risk factors for functional limitations in patients with long-standing ankylosing spondylitis.
AU - Ward MM
AU - Weisman MH
AU - Davis JC Jr.
AU - Reveille JD
Y1 - 2005/10/15/
N1 - Accession Number: 106290866. Language: English. Entry Date: 20070525. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire modified for the Spondylarthropathies (HAQS). Grant Information: Supported in part by US Public Health Service grants AR-48465, AR-46208, M01-RR000079, M01-RR02558, and M01-RR00425, and by the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases. NLM UID: 0370605.
KW - Disabled
KW - Spondylitis, Ankylosing -- Physiopathology
KW - Work Capacity Evaluation
KW - Age of Onset
KW - Clinical Assessment Tools
KW - Comorbidity
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Disabled -- Classification
KW - Female
KW - Funding Source
KW - Health Status
KW - Male
KW - Middle Age
KW - Multiple Linear Regression
KW - Pearson's Correlation Coefficient
KW - Regression
KW - Risk Factors
KW - Severity of Illness Indices
KW - Spearman's Rank Correlation Coefficient
KW - Spondylitis, Ankylosing -- Epidemiology
KW - Time Factors
KW - Two-Tailed Test
KW - Univariate Statistics
KW - Human
SP - 710
EP - 717
JO - Arthritis & Rheumatism: Arthritis Care & Research
JF - Arthritis & Rheumatism: Arthritis Care & Research
JA - ARTHRITIS RHEUM (ARTHRITIS CARE RES)
VL - 53
IS - 5
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. wardm1@mail.nih.gov
U2 - PMID: 16208654.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106290866&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zifei Liu
AU - Mingming Lu
AU - Birch, M. Eileen
AU - Keener, Tim C.
AU - Soon-Jai Khang
AU - Fuyan Liang
T1 - Variations of the Particulate Carbon Distribution from a Nonroad Diesel Generator.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2005/10/15/
VL - 39
IS - 20
M3 - Article
SP - 7840
EP - 7844
SN - 0013936X
AB - The emissions of diesel particulate matter (DPM) from diesel engines are causing increasing health concerns due to their suspected carcinogenicity, especially the carbonaceous fractions. The total DPM emissions and the organic and elemental carbon (OC and EC) distributions of the DPM depend on many operating factors, such as load, engine design parameters, fuel sulfur content, fuel usage rate, and sampling conditions. Results of previous studies on the OC/EC variations with load for heavy-duty vehicles have been reported, but information is scarce for nonroad diesel generators. There is a clear need to better characterize nonroad DPM emissions, as studies have indicated that DPM emissions from nonroad diesel engines are significantly higher than those from on-road sources. The objective of the study is to provide a detailed account of the OC/EC distributions for a nonroad diesel generator operated with high and low sulfur fuels under different load conditions. DPM emissions were collected using an EPA Method 5 (Determination of Particulate Matter Emissions from Stationary Sources) sampling train. The OC and EC concentrations were quantified by NIOSH Method 5040. DPM concentrations and the relative contributions of OC, EC, and noncarbonaceous materials vary significantly with engine load, fuel sulfur content, and sample collection temperature. The fractions of EC over DPM increase with increasing load from 21% at OkW to 84% at 75 kW for the low sulfur fuel, while those of OC decrease from 62% to 9%. This is consistent with other studies, and the same trends exist regardless of the sulfur content and DPM collection temperature. The fractions of organic compounds range from 77% to 19% for the high sulfur fuel. Noncarbonaceous materials are from 27% to 18% in fraction from high sulfur DPM as opposed to the 17% to 7% in the low sulfur diesel emissions. At lower collection temperatures, more OC and noncarbonaceous materials are observed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carbon
KW - Carcinogenicity
KW - Air pollution
KW - Diesel fuels
KW - Atmospheric deposition
KW - Environmental protection
N1 - Accession Number: 19153861; Zifei Liu 1; Mingming Lu 1; Email Address: mingming.lu@uc.edu; Birch, M. Eileen 2; Keener, Tim C. 1; Soon-Jai Khang 3; Fuyan Liang 1; Affiliations: 1: Department of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45221.; 2: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, Ohio 45226.; 3: Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45221.; Issue Info: 10/15/2005, Vol. 39 Issue 20, p7840; Thesaurus Term: Carbon; Thesaurus Term: Carcinogenicity; Thesaurus Term: Air pollution; Thesaurus Term: Diesel fuels; Thesaurus Term: Atmospheric deposition; Thesaurus Term: Environmental protection; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1021/es048373d
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19153861&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cantalupo, Paul
AU - Doering, Adrienne
AU - Sullivan, Christopher S.
AU - Pal, Achintya
AU - Peden, K. W. C.
AU - Lewis, Andrew M.
AU - Pipas, James M.
T1 - Complete Nucleotide Sequence of Polyomavirus SA12.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/10/15/
VL - 79
IS - 20
M3 - Article
SP - 13094
EP - 13104
SN - 0022538X
AB - The Polyomaviridae have small icosahedral virions that contain a genuine of approximately 5,000 bp of circular double-stranded DNA. Polyomaviruses infect hosts ranging from humans to birds, and some members of this family induce tumors in test animals or in their natural hosts. We report the complete nucleotide sequence of simian agent 12 (SA12), whose natural host is thought to be Papio ursinus, the chacma baboon. The 5,230-bp genome has a genetic organization typical of polyomaviruses. Sequences encoding large T antigen, small t antigen, agnoprotein, and the viral capsid proteins VP1, VP2, and VP3 are present in the expected locations. We show that, like its close relative simian virus 40 (SV40), SA12 expresses microRNAs that are encoded by the late DNA strand overlapping the 3′ end of large T antigen coding sequences. Based on sequence comparisons, SA12 is most closely related to BK virus (BKV), a human polyomavirus. We have developed a real-time PCR test that distinguishes SA12 from BKV and the other closely related polyomaviruses JC virus and SV40. The close relationship between SA12 and BKV raises the possibility that these viruses circulate between human and baboon hosts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEOTIDE sequence
KW - POLYOMAVIRUSES
KW - PAPILLOMAVIRUSES
KW - DNA
KW - DEOXYRIBOSE
KW - NUCLEIC acids -- Analysis
KW - NUCLEOTIDES -- Analysis
N1 - Accession Number: 18536973; Cantalupo, Paul 1 Doering, Adrienne 1,2 Sullivan, Christopher S. 3 Pal, Achintya 4 Peden, K. W. C. 4 Lewis, Andrew M. 4 Pipas, James M. 1; Email Address: pipas@pitt.edu; Affiliation: 1: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 2: University of Pennsylvania School of Veterinary Medicine, 3800 Spruce St., Philadelphia, PA 19104 3: Howard Hughes Medical Institute and Departments of Microbiology and Medicine, G. W. Hooper Foundation, University of California, San Francisco, California 94143 4: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Oct2005, Vol. 79 Issue 20, p13094; Subject Term: NUCLEOTIDE sequence; Subject Term: POLYOMAVIRUSES; Subject Term: PAPILLOMAVIRUSES; Subject Term: DNA; Subject Term: DEOXYRIBOSE; Subject Term: NUCLEIC acids -- Analysis; Subject Term: NUCLEOTIDES -- Analysis; Number of Pages: 11p; Illustrations: 7 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/JVI.79.20.13094-13104.2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18536973&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bendre, Sachin V.
AU - Shaddock, Joseph G.
AU - Patton, Ralph E.
AU - Dobrovolsky, Vasily N.
AU - Albertini, Richard J.
AU - Heflich, Robert H.
T1 - Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2005/10/15/
VL - 578
IS - 1/2
M3 - Article
SP - 1
EP - 14
SN - 00275107
AB - Abstract: Many patients undergoing chronic therapy with the purine analogue Azathioprine (Aza) have highly elevated HPRT lymphocyte mutant frequencies (MFs), and it is likely that these increases are due to selection of pre-existing HPRT mutant lymphocytes. A similar selection in germ cells might result in an increased frequency of the Lesch-Nyhan syndrome. In this study, a mouse model for Aza mutant selection was developed and Aza toxicity was evaluated in the germ cells of treated mice. Groups of 20 male C57BL/6 mice were treated by gavage three times/week with 0, 5, 10, 25, 50, or 100mg/kg Aza, and three to eight mice from each group were sacrificed at various times for up to 23 weeks. Mice treated with 25–100mg/kg Aza were all dead by 14 weeks of treatment. Hprt lymphocyte MF assays indicated that the treated mice had reduced numbers of spleen lymphocytes. Most treated mice had Hprt MFs similar to those of control mice (2.1±1.6×10−6), however, highly elevated MFs were detected in one out of three mice given 5mg/kg for 10 weeks, one out of three mice given 10mg/kg for 10 weeks, and one out of eight mice given 10mg/kg for 23 weeks (e.g., 233×10−6 after 10 weeks of 5mg/kg). Sequence analysis of Hprt cDNA indicated that all mutant clones from one of these mice had a T→A transversion in the initiation codon. Multiplex-PCR on mutant clones from the other two mice indicated that all the clones from one had a deletion of Hprt exons 2 and 3, while most of the mutants from the other had lost all of the Hprt exons. Measurements of testicular weight, and of sperm count, viability, morphology, and motility found that Aza produced low levels of toxicity in sperm, with the most consistent effect being a reduction in the testicular weight. The data suggest that mice chronically treated with 5 and 10mg/kg Aza (doses similar to those used in humans) have elevated Hprt MFs due to clonal amplification of selected Hprt mutants. The results also suggest that mice treated with these doses of Aza retain reasonable fertility, and will be useful for breeding experiments to examine the possibility of increasing the germ-line transmission of Hprt mutations. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - SPERMATOZOA
KW - LYMPHOID tissue
KW - HYPERURICEMIA
KW - Azathioprine
KW - Hprt mutation
KW - Mutant selection
KW - Sperm toxicity
N1 - Accession Number: 18731898; Bendre, Sachin V. 1,2 Shaddock, Joseph G. 2 Patton, Ralph E. 3 Dobrovolsky, Vasily N. 2 Albertini, Richard J. 4 Heflich, Robert H. 1,2; Email Address: rheflich@nctr.fda.gov; Affiliation: 1: University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, AR, USA 2: National Center for Toxicological Research/US FDA, Division of Genetic and Reproductive Toxicology, HFT-120, 3900 NCTR Drive, Jefferson, AR 72079, USA 3: Charles River Laboratories, Jefferson, AR, USA 4: University of Vermont, Genetic Toxicology Laboratory, Burlington, VT, USA; Source Info: Oct2005, Vol. 578 Issue 1/2, p1; Subject Term: LYMPHOCYTES; Subject Term: SPERMATOZOA; Subject Term: LYMPHOID tissue; Subject Term: HYPERURICEMIA; Author-Supplied Keyword: Azathioprine; Author-Supplied Keyword: Hprt mutation; Author-Supplied Keyword: Mutant selection; Author-Supplied Keyword: Sperm toxicity; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2004.09.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18731898&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sean Gallagher
T1 - Torso Flexion Loads and the Fatigue Failure of Human Lumbosacral Motion Segments.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2005/10/15/
VL - 30
IS - 20
M3 - Article
SP - 2265
EP - 2273
SN - 03622436
AB - STUDY DESIGN.: Spine loads associated with lifting a 9-kg weight were estimated at three torso flexion angles (0°, 22.5°, and 45°), and lumbosacral motion segments were cyclically loaded using these loads until failure or to a maximum of 10,020 cycles.OBJECTIVES.: To simulate the postures and loads experienced by the lumbar spine during repetitive lifting of moderate weights in different torso flexion postures, and to analyze the fatigue failure response of lumbosacral motion segments.SUMMARY OF BACKGROUND DATA.: Previous fatigue failure studies of lumbar motion segments have not reproduced the combination of spinal postures, loads, and load rates anticipated in different torso flexion postures during lifting tasks characteristic of those in occupational settings.METHODS.: Twelve fresh human lumbosacral spines were dissected into three motion segments each (L1–L2, L3–L4, and L5–S1). Motion segments within each spine were randomly assigned to a simulated torso flexion angle (0°, 22.5°, or 45°) using a partially balanced incomplete block experimental design. Spinal load and load rate were determined for each torso flexion angle using previously collected data from an EMG-assisted biomechanical model. Motion segments were creep loaded for 15 minutes, then cyclically loaded at 0.33 Hz. Fatigue life was taken as the number of cycles to failure (10 mm displacement after creep loading). Specimens were inspected to determine failure mechanisms.RESULTS.: The degree of torso flexion had a dramatic impact on cycles to failure. Motion segments experiencing the 0° torso flexion condition averaged 8,253 cycles to failure (±2,895), while the 22.5° torso flexion angle averaged 3,257 (±4,443) cycles to failure, and motion segments at the 45° torso flexion angle lasted only 263 cycles(±646), on average. The difference was significant at P < 0.0001, and torso flexion accounted for 50% of the total variance in cycles to failure.CONCLUSIONS.: Fatigue failure of spinal tissues can occur rapidly when the torso is fully flexed during occupational lifting tasks; however, many thousands of cycles canbe tolerated in a neutral posture. Future lifting recommendations should be sensitive to rapid development of fatigue failure in torso flexion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Spine (03622436) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKELETON
KW - POSTURE
KW - FATIGUE
KW - BONES
N1 - Accession Number: 20110974; Sean Gallagher 1; Affiliation: 1: From the *National Institute for Occupational Safety and Health, Pittsburgh, PA; and †Biodynamics Laboratory, ‡Orthopaedic BioMaterials Laboratory, and §Division of Epidemiology and Biometrics, Ohio State University, Columbus, OH.; Source Info: Oct2005, Vol. 30 Issue 20, p2265; Subject Term: SKELETON; Subject Term: POSTURE; Subject Term: FATIGUE; Subject Term: BONES; Number of Pages: 9p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20110974&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Angeles-Boza, Alfredo M.
AU - Bradley, Patricia M.
AU - Patty K.-L. Fu
AU - Shatruk, Mikhail
AU - Hilfiger, Matthew G.
AU - Dunbar, Kim R.
AU - Turro, Claudia
T1 - Photocytotoxicity of a New Rh2(II,III) Complex: Increase in Cytotoxicity upon Irradiation Similar to That of PDT Agent Hematoporphyrin.
JO - Inorganic Chemistry
JF - Inorganic Chemistry
Y1 - 2005/10/17/
VL - 44
IS - 21
M3 - Article
SP - 7262
EP - 7264
SN - 00201669
AB - A new type of heteroleptic dirhodium complex cis-[Rh2(μO2CCH3)2(bpy)(dppz)]2+ (3) was synthesized and its potential as a photodynamic therapy (PDT) agent was investigated. Although 27% hypochromicity of the absorption of 3 in the near-UV and visible regions is observed in the presence of duplex DNA, relative viscosity measurements reveal that the complex does not intercalate between the DNA bases. The DNA photocleavage with visible light by 3 proceeds via both oxygen dependent and independent mechanisms, and it is more efficient than that of related complexes. The increase in the cytotoxicity of 3 towards human skin cells is similar to that of hematoporphyrin, a key ingredient in a PDT drug currently in use. This feature makes this complex a useful candidate for further PDT studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inorganic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPLEX compounds
KW - PHOTOCHEMOTHERAPY
KW - CELL-mediated cytotoxicity
KW - IRRADIATION
KW - DNA
KW - SCISSION (Chemistry)
KW - HEMATOPORPHYRIN
N1 - Accession Number: 18673274; Angeles-Boza, Alfredo M. 1 Bradley, Patricia M. 2 Patty K.-L. Fu 3 Shatruk, Mikhail 1 Hilfiger, Matthew G. 1 Dunbar, Kim R. 1; Email Address: dunbar@mail.chem.tamu.edu Turro, Claudia 2; Email Address: turro.1@osu.edu; Affiliation: 1: Department of Chemistry, Texas A&M University, College Station, Texas 77842 2: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210 3: Food and Drug Administration, College Park, Maryland 20740; Source Info: 10/17/2005, Vol. 44 Issue 21, p7262; Subject Term: COMPLEX compounds; Subject Term: PHOTOCHEMOTHERAPY; Subject Term: CELL-mediated cytotoxicity; Subject Term: IRRADIATION; Subject Term: DNA; Subject Term: SCISSION (Chemistry); Subject Term: HEMATOPORPHYRIN; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 3p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1021/ic0500715
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mark, C.
AU - Molinda, G.M.
T1 - The Coal Mine Roof Rating (CMRR)—a decade of experience
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2005/10/17/
VL - 64
IS - 1/2
M3 - Article
SP - 85
EP - 103
SN - 01665162
AB - Abstract: The Coal Mine Roof Rating (CMRR) was developed 10 years ago to fill the gap between geologic characterization and engineering design. It combines many years of geologic studies in underground coal mines with worldwide experience with rock mass classification systems. Like other classification systems, the CMRR begins with the premise that the structural competence of mine roof rock is determined primarily by the discontinuities that weaken the rock fabric. However, the CMRR is specifically designed for bedded coal measure rock. Since its introduction, the CMRR has been incorporated into many aspects of mine planning, including longwall pillar design, roof support selection, feasibility studies, extended cut evaluation, and others. It has also become truly international, with involvement in mine designs and funded research projects in South Africa, Canada, and Australia. This paper discusses the sources used in the development of the CMRR, describes the CMRR data collection and calculation procedures, and briefly presents a number of practical mining applications in which the CMRR has played a prominent role. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - COAL industry
KW - MINES & mineral resources
KW - ROCK mechanics
KW - Geologic hazards
KW - Ground control
KW - Rock mass classification
KW - Roof support
KW - Underground mining
N1 - Accession Number: 18729181; Mark, C.; Email Address: cnm7@cdc.gov Molinda, G.M. 1; Affiliation: 1: National Institute of Occupational Safety and Health, P.O. Box 18070, Pittsburgh, PA, 15236, USA; Source Info: Oct2005, Vol. 64 Issue 1/2, p85; Subject Term: COAL mines & mining; Subject Term: COAL industry; Subject Term: MINES & mineral resources; Subject Term: ROCK mechanics; Author-Supplied Keyword: Geologic hazards; Author-Supplied Keyword: Ground control; Author-Supplied Keyword: Rock mass classification; Author-Supplied Keyword: Roof support; Author-Supplied Keyword: Underground mining; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.coal.2005.03.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106247981
T1 - Women's health and the FDA.
AU - Wood SF
Y1 - 2005/10/20/
N1 - Accession Number: 106247981. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Contraceptives, Postcoital -- Administration and Dosage
KW - United States Food and Drug Administration
KW - Women's Health
KW - Female
SP - 1650
EP - 1651
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 353
IS - 16
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Office of Women's Health at the Food and Drug Administration, Rockville, Md, USA.
U2 - PMID: 16236734.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Atkins, David
AU - Moy, Ernest M.
T1 - Left behind: the legacy of hurricane Katrina.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2005/10/22/
VL - 331
IS - 7522
M3 - Editorial
SP - 916
EP - 918
SN - 09598146
AB - The editorial focuses on policy changes that should be made, in the aftermath of Hurricane Katrina. Government and private agencies should develop a comprehensive plan that funds prevention instead of rescue, strengthens the public health infrastructure, recognizes the regional and socioeconomic disparities that affect choices, improves communication concerning health threats, and builds strategies that promote accountability for emergency disaster preparation.
KW - EMERGENCY management
KW - DISASTERS
KW - GOVERNMENT policy
KW - PUBLIC health
N1 - Accession Number: 18680179; Atkins, David 1; Email Address: datkins@ahrq.gov Moy, Ernest M. 2; Affiliation: 1: Chief medical officer, Center for Outcome and Effectiveness, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA 2: Senior service fellow, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA; Source Info: 10/22/2005, Vol. 331 Issue 7522, p916; Subject Term: EMERGENCY management; Subject Term: DISASTERS; Subject Term: GOVERNMENT policy; Subject Term: PUBLIC health; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106358640
T1 - Left behind: the legacy of hurricane Katrina.
AU - Atkins D
AU - Moy EM
Y1 - 2005/10/22/
N1 - Accession Number: 106358640. Language: English. Entry Date: 20061110. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866.
KW - Louisiana
KW - Natural Disasters
KW - Poverty
KW - Public Health
KW - Racism
SP - 916
EP - 918
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
JA - BMJ
VL - 331
IS - 7522
PB - BMJ Publishing Group
SN - 0959-8146
AD - Chief Medical Officer, Center for Outcome and Effectiveness, Agency for Healthcare Research and Quality, Rockville, MD 20850; datkins@ahrq.gov
U2 - PMID: 16239669.
DO - 10.1136/bmj.331.7522.916
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - LaKind, Judy S.
AU - Brent, Robert L.
AU - Dourson, Michael L.
AU - Kacew, Sam
AU - Koren, Gideon
AU - Sonawane, Babasaheb
AU - Tarzian, Anita J.
AU - Uhl, Kathleen
T1 - Human Milk Biomonitoring Data: Interpretation and Risk Assessment Issues.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/10/22/
VL - 68
IS - 20
M3 - Article
SP - 1713
EP - 1769
SN - 15287394
AB - Biomonitoring data can, under certain conditions, be used to describe potential risks to human health (for example, blood lead levels used to determine children’s neurodevelopmental risk). At present, there are very few chemical exposures at low levels for which sufficient data exist to state with confidence the link between levels of environmental chemicals in a person’s body and his or her risk of adverse health effects. Human milk biomonitoring presents additional complications. Human milk can be used to obtain information on both the levels of environmental chemicals in the mother and her infant’s exposure to an environmental chemical. However, in terms of the health of the mother, there are little to no extant data that can be used to link levels of most environmental chemicals in human milk to a particular health outcome in the mother. This is because, traditionally, risks are estimated based on dose, rather than on levels of environmental chemicals in the body, and the relationship between dose and human tissue levels is complex. On the other hand, for the infant, some information on dose is available because the infant is exposed to environmental chemicals in milk as a “dose” from which risk estimates can be derived. However, the traditional risk assessment approach is not designed to consider the benefits to the infant associated with breastfeeding and is complicated by the relatively short-term exposures to the infant from breastfeeding. A further complexity derives from the addition of in utero exposures, which complicates interpretation of epidemiological research on health outcomes of breastfeeding infants. Thus, the concept of “risk assessment” as it applies to human milk biomonitoring is not straightforward, and methodologies for undertaking this type of assessment have not yet been fully developed. This article describes the deliberations of the panel convened for the Technical Workshop on Human Milk Surveillance and Biomonitoring for Environmental Chemicals in the United States, held at the Hershey Medical Center, Pennsylvania State College of Medicine, on several issues related to risk assessment and human milk biomonitoring. Discussion of these topics and the thoughts and conclusions of the panel are described in this article. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST milk
KW - MILK
KW - BREASTFEEDING (Humans)
KW - BIOLOGICAL monitoring
KW - TOXICOLOGY
KW - RISK assessment
KW - PENNSYLVANIA
N1 - Accession Number: 18333757; LaKind, Judy S. 1,2; Email Address: lakindassoc@comcast.net Brent, Robert L. 3 Dourson, Michael L. 4 Kacew, Sam 5 Koren, Gideon 6 Sonawane, Babasaheb 7,8 Tarzian, Anita J. 9 Uhl, Kathleen 10; Affiliation: 1: Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 2: LaKind Associates, LLC Catonsville, Maryland, USA 3: Jefferson Medical College of Thomas Jefferson University, A. I. duPont Hospital for Children, Wilmington, Delaware, USA 4: Toxicology Excellence for Risk Assessment, Cincinnati, Ohio, USA 5: Department of Pharmacology, University of Ottawa, Ottawa, Ontario, Canada 6: Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children Molecular Toxicology, University of Western Ontario, Ontario, Canada 7: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA 8: Ethics and Research Consultant, Baltimore, Maryland, Law and Health Care Program, School of Law, University of Maryland, Baltimore, Maryland 9: School of Nursing, University of Maryland, Baltimore, Maryland, USA 10: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Pregnancy Labeling Team, Rockville, Maryland, USA; Source Info: 2005, Vol. 68 Issue 20, p1713; Subject Term: BREAST milk; Subject Term: MILK; Subject Term: BREASTFEEDING (Humans); Subject Term: BIOLOGICAL monitoring; Subject Term: TOXICOLOGY; Subject Term: RISK assessment; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 57p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1080/15287390500225724
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Richard Y.
AU - Bates, Michael N.
AU - Goldstein, Daniel A.
AU - Haynes, Suzanne G.
AU - Hench, Karen D.
AU - Lawrence, Ruth A.
AU - Paul, Ian M.
AU - Zhengmin Qian
T1 - Human Milk Research for Answering Questions about Human Health.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/10/22/
VL - 68
IS - 20
M3 - Article
SP - 1771
EP - 1801
SN - 15287394
AB - Concerns regarding human milk in our society are diverse, ranging from the presence of environmental chemicals to the health of breastfed infants and the economic value of breastfeeding to society. The panel convened for the Technical Workshop on Human Milk Surveillance and Biomonitoring for Environmental Chemicals in the United States, held at the Hershey Medical Center, Pennsylvania State College of Medicine, on 24–26 September 2004, considered how human milk research may contribute to environmental health initiatives to benefit society. The panel concluded that infant, maternal, and community health can benefit from studies using human milk biomonitoring. Unlike other biological specimens, human milk provides information regarding exposure of the mother and breastfed infant to environmental chemicals. Some of the health topics relevant to this field of research include disorders of growth and development in infants, cancer origins in women, and characterization of the trend of exposure to environmental chemicals in the community. The research focus will determine the design of the study and the need for the collection of alternative biological specimens and the long-term storage of these specimens. In order to strengthen the ability to interpret study results, it is important to identify reference ranges for the chemicals measured and to control for populations with high environmental chemical exposure, because the amount of data on environmental chemical levels in human milk that is available for comparison is extremely limited. In addition, it will be necessary to validate models used to assess infant exposure from breastfeeding because of the variable nature of current models. Information on differences between individual and population risk estimates for toxicity needs to be effectively communicated to the participant. Human milk research designed to answer questions regarding health will require additional resources to meet these objectives. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST milk
KW - RESEARCH
KW - MILK
KW - BREASTFEEDING (Humans)
KW - INFANT nutrition
KW - PUBLIC health
KW - HEALTH
KW - PENNSYLVANIA
N1 - Accession Number: 18333758; Wang, Richard Y. 1; Email Address: RYWang@cdc.gov Bates, Michael N. 2 Goldstein, Daniel A. 3 Haynes, Suzanne G. 4 Hench, Karen D. 5 Lawrence, Ruth A. 6 Paul, Ian M. 7 Zhengmin Qian 8; Affiliation: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA 3: Monsanto Company, St. Louis, Missouri, USA 4: Office on Women's Health, Department of Health and Human Services, Washington, DC, USA 5: Division of Perinatal Systems and Women's Health, Maternal and Child Health Bureau Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland, USA 6: Children's Hospital at Strong, Breastfeeding and Human Lactation Study Center, University of Rochester, Rochester, New York, USA 7: Departments of Pediatrics and Health Evaluation Sciences, Children's Hospital, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA 8: Department of Health Evaluation Sciences, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA; Source Info: 2005, Vol. 68 Issue 20, p1771; Subject Term: BREAST milk; Subject Term: RESEARCH; Subject Term: MILK; Subject Term: BREASTFEEDING (Humans); Subject Term: INFANT nutrition; Subject Term: PUBLIC health; Subject Term: HEALTH; Subject Term: PENNSYLVANIA; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 31p; Document Type: Article
L3 - 10.1080/15287390500226706
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Berlin Jr., Cheston M.
AU - LaKind, Judy S.
AU - Fenton, Suzanne E.
AU - Wang, Richard Y.
AU - Bates, Michael N.
AU - Brent, Robert L.
AU - Condon, Marian
AU - Crase, Betty L.
AU - Dourson, Michael L.
AU - Ettinger, Adrienne S.
AU - Foos, Brenda
AU - Fürst, Peter
AU - Giacoia, George P.
AU - Goldstein, Daniel A.
AU - Haynes, Suzanne G.
AU - Hench, Karen D.
AU - Kacew, Sam
AU - Koren, Gideon
AU - Lawrence, Ruth A.
AU - Mason, Ann
T1 - Conclusions and Recommendations of the Expert Panel: Technical Workshop on Human Milk Surveillance and Biomonitoring for Environmental Chemicals in the United States.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2005/10/22/
VL - 68
IS - 20
M3 - Article
SP - 1825
EP - 1831
SN - 15287394
AB - This article presents the conclusions and recommendations of the expert panel for the Technical Workshop on Human Milk Surveillance and Biomonitoring for Environmental Chemicals in the U.S. and held at the Hershey S. Medical Center in Pennsylvania State University College of Medicine on September 24-26, 2004. The Technical Workshop focused on questions related to interpretation of information gathered from human milk biomonitoring studies. Biomonitoring can measure a person's exposure to a chemical in his/her tissue. It is noted here that many of the conclusions and research needs enumerated by the panel from the first workshop remain important and relevant.
KW - FORUMS (Discussion & debate)
KW - BREAST milk
KW - MILK
KW - BIOLOGICAL monitoring
KW - RESEARCH
KW - PENNSYLVANIA
KW - HERSHEY (Pa.)
N1 - Accession Number: 18333753; Berlin Jr., Cheston M. 1; Email Address: cmb6@psu.edu LaKind, Judy S. 2 Fenton, Suzanne E. 3 Wang, Richard Y. 4 Bates, Michael N. 5 Brent, Robert L. 6 Condon, Marian 7 Crase, Betty L. 8 Dourson, Michael L. 9 Ettinger, Adrienne S. 10 Foos, Brenda 11 Fürst, Peter 12 Giacoia, George P. 13 Goldstein, Daniel A. 14 Haynes, Suzanne G. 15 Hench, Karen D. 16 Kacew, Sam 17 Koren, Gideon 18 Lawrence, Ruth A. 19 Mason, Ann 20; Affiliation: 1: Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA 2: LaKind Associates, LLC, Catonsville, Maryland 3: National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA 4: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 5: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA 6: A. I. duPont Hospital for Children, Wilmington, Delaware, USA 7: Occupational Health Program, University of Maryland School of Medicine, Baltimore, Maryland, USA 8: Breastfeeding Initiatives, Division of Community Health Services, American Academy of Pediatrics, Elk Grove Village, Illinois, USA 9: Toxicology Excellence for Risk Assessment, Cincinnati, Ohio, USA 10: Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, USA 11: Office of Children's Health Protection, US Environmental Protection Agency, Washington, DC, USA 12: Chemical and Veterinary Control Laboratory, Muenster, Germany 13: Pediatric Pharmacology Research Unit Network, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA 14: Monsanto Company, St. Louis, Missouri, USA 15: Office of Women's Health, Department of Health and Human Services, Washington, DC, USA 16: U.S. Public Health Service, Division of Perinatal Systems, and Women's Health Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland, USA 17: Department of Pharmacology, University of Ottawa, Ottawa, Ontario, Canada 18: Division of Clinical Pharmacology and Toxicology, Hospital For Sick Children Molecular Toxicology, University of Western Ontario, Ontario, Canada 19: Golisano Children's Hospital at Strong, Breastfeeding and Human Lactation Study Center, University of Rochester, Rochester, New York, USA 20: Research Foundation for Health and Environmental Effects, Arlington, Virginia, USA; Source Info: 2005, Vol. 68 Issue 20, p1825; Subject Term: FORUMS (Discussion & debate); Subject Term: BREAST milk; Subject Term: MILK; Subject Term: BIOLOGICAL monitoring; Subject Term: RESEARCH; Subject Term: PENNSYLVANIA; Subject Term: HERSHEY (Pa.); NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/15287390500226896
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hampshire, Victoria A.
T1 - Evaluation of efficacy of heartworm preventive products at the FDA
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2005/10/24/
VL - 133
IS - 2/3
M3 - Article
SP - 191
EP - 195
SN - 03044017
AB - Abstract: The Center for Veterinary Medicine, U.S. Food and Drug Administration (FDA/CVM) has authority under the United States Code 21 under Section 514.80 to monitor for adverse experiences of approved animal products. Although veterinarians voluntarily report suspect drug-related events to manufacturers, firms that market FDA-approved animal products must report serious events to the FDA within 15 working days of the veterinarian or pet-owner''s call to them. Under the present regulations, canine heartworm preventatives are approved for 100% efficacy after testing in laboratory and field conditions. The report of lack of efficacy against heartworm larvae is a serious adverse drug event because the resulting condition or the treatment of the condition is life threatening. Information on lack of effect that are deemed possibly, probably, or definitely drug-related available for review under generic product on the FDA/CVM website Surveillance of these reports indicates there are some failures for virtually all heartworm prevention product categories. Most failures have been reported in heartworm-endemic states. At this time, it is unclear whether these are representative of the rare occurrences of failure that have been in existence for a long time, but not reported regularly or promptly, or whether there is a true increase in complaints of ineffectiveness and real variability between products. This paper discusses methods, personnel, and procedures in place in the Division of Surveillance that will aid the FDA to better assess heartworm preventive treatment failures. It discusses scoring paradigms presently utilized by FDA/CVM to assess severity of complaints of lack of efficacy against heartworms, and welcomes audience input as to how to improve existing processes. Results suggest that more comprehensive reporting will provide FDA/CVM more accurate surveillance information regarding efficacy problems. Such practices will permit FDA/CVM to better interpret both incidence and severity of in-effect and possible patterns of emerging resistance and to convey this in any necessary updated labeling. It also indicates that as part of that process, practitioners should return to a more conservative testing schedule. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL specialists
KW - ANIMAL health
KW - UNITED States
KW - Adverse event
KW - Dirofilaria immitis
KW - Heartworm
KW - Preventative
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 18629995; Hampshire, Victoria A. 1; Affiliation: 1: Center for Veterinary Medicine, U.S. Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855-0001, USA; Source Info: Oct2005, Vol. 133 Issue 2/3, p191; Subject Term: ANIMAL specialists; Subject Term: ANIMAL health; Subject Term: UNITED States; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Dirofilaria immitis; Author-Supplied Keyword: Heartworm; Author-Supplied Keyword: Preventative; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.04.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Churchwell, Mona I.
AU - Twaddle, Nathan C.
AU - Meeker, Larry R.
AU - Doerge, Daniel R.
T1 - Improving LC–MS sensitivity through increases in chromatographic performance: Comparisons of UPLC–ES/MS/MS to HPLC–ES/MS/MS
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2005/10/25/
VL - 825
IS - 2
M3 - Article
SP - 134
EP - 143
SN - 15700232
AB - Abstract: Recent technological advances have made available reverse phase chromatographic media with a 1.7μm particle size along with a liquid handling system that can operate such columns at much higher pressures. This technology, termed ultra performance liquid chromatography (UPLC), offers significant theoretical advantages in resolution, speed, and sensitivity for analytical determinations, particularly when coupled with mass spectrometers capable of high-speed acquisitions. This paper explores the differences in LC–MS performance by conducting a side-by-side comparison of UPLC for several methods previously optimized for HPLC-based separation and quantification of multiple analytes with maximum throughput. In general, UPLC produced significant improvements in method sensitivity, speed, and resolution. Sensitivity increases with UPLC, which were found to be analyte-dependent, were as large as 10-fold and improvements in method speed were as large as 5-fold under conditions of comparable peak separations. Improvements in chromatographic resolution with UPLC were apparent from generally narrower peak widths and from a separation of diastereomers not possible using HPLC. Overall, the improvements in LC–MS method sensitivity, speed, and resolution provided by UPLC show that further advances can be made in analytical methodology to add significant value to hypothesis-driven research. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIQUID chromatography
KW - MASS spectrometers
KW - HIGH performance liquid chromatography
KW - SEPARATION (Technology)
KW - CHROMATOGRAPHIC analysis
KW - β-Agonists
KW - Ephedra alkaloids
KW - Isoflavones
KW - Mass spectrometry
KW - Tamoxifen
KW - UPLC
N1 - Accession Number: 18730793; Churchwell, Mona I. 1 Twaddle, Nathan C. 1 Meeker, Larry R. 2 Doerge, Daniel R. 1; Email Address: ddoerge@nctr.fda.gov; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA 2: Waters Corporation, Milford, MA, USA; Source Info: Oct2005, Vol. 825 Issue 2, p134; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometers; Subject Term: HIGH performance liquid chromatography; Subject Term: SEPARATION (Technology); Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: β-Agonists; Author-Supplied Keyword: Ephedra alkaloids; Author-Supplied Keyword: Isoflavones; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Tamoxifen; Author-Supplied Keyword: UPLC; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jchromb.2005.05.037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zuocheng Wang
AU - Hopke, Philip K.
AU - Baron, Paul A.
AU - Ahmadi, Goodarz
AU - Yung-Sung Cheng
AU - Deye, Gregory
AU - Wei-Chung Su
T1 - Fiber Classification and the Influence of Average Air Humidity.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2005/11//
VL - 39
IS - 11
M3 - Article
SP - 1056
EP - 1063
SN - 02786826
AB - The use of man-made vitreous fibers (MMVFs) as a substitute for asbestos in industrial and residential applications has raised the concerns of the potential hazards associated with inhalable aerosolized fibers. The complex movement of fiber makes it difficult to predict the pattern of fiber deposition in human airways from the behavior of spherical particles. Difficulties in producing monodisperse length fibers has been an obstacle to study fibrous particle deposition in the human respiratory system. To address this problem, a narrow length distribution of fibers was generated using dielectrophoretic classification. Dielectrophoresis is the motion of neutral matter in a nonuniform electric field due to an induced dipole moment. It is sensitive to the conductivity of the matter in the field. A fiber classifier has been used to study the influence of atmospheric humidity on the behavior of glass fibers. Glass fibers, as insulators, can not be classified by the dielectrophoretic classifier. However, our study shows that a humidity higher than 15% RH can change the conductivity of the glass fibers so as to permit their effective classification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBERS
KW - PLANT products
KW - ASBESTOS
KW - INDUSTRIAL applications
KW - MATTER -- Properties
KW - CHEMICAL processes
KW - SURFACE chemistry
N1 - Accession Number: 19114479; Zuocheng Wang 1 Hopke, Philip K. 1; Email Address: hopkepk@clarkson.edu Baron, Paul A. 2 Ahmadi, Goodarz 1 Yung-Sung Cheng 3 Deye, Gregory 2 Wei-Chung Su 3; Affiliation: 1: Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York, USA 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA 3: Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA; Source Info: Nov2005, Vol. 39 Issue 11, p1056; Subject Term: FIBERS; Subject Term: PLANT products; Subject Term: ASBESTOS; Subject Term: INDUSTRIAL applications; Subject Term: MATTER -- Properties; Subject Term: CHEMICAL processes; Subject Term: SURFACE chemistry; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/02786820500380198
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Min Qi Wang
AU - Matthew, Resa F.
AU - Bellamy, Nikki
AU - James, Syretta
T1 - A Structural Model of the Substance Use Pathways Among Minority Youth.
JO - American Journal of Health Behavior
JF - American Journal of Health Behavior
Y1 - 2005/11//Nov/Dec2005
VL - 29
IS - 6
M3 - Article
SP - 531
EP - 541
SN - 10873244
AB - Objective: To evaluate the substance use pathways of minority adolescents with a structural equation modeling (SEM) based on the social ecological model. Method: Seven hundred ninety adolescents completed the baseline survey questionnaire for the Center for Substance Abuse Prevention's Mentoring and Family Strengthening Initiative. The exogenous variables were family supervision, family involvement, and social support, whereas self-control, school connectedness, and substance use served as the endogenous variables. Results: The following significant direct effects were found: family involvement to self-control; self-control and social support to school connectedness; school connectedness to substance use. Conclusions: These findings provide empirical evidence that family protective factors can significantly Influence adolescents' substance use and should be adopted into substance use prevention interventions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health Behavior is the property of PNG Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINORITY youth
KW - DRUG use testing
KW - CONTROL (Psychology)
KW - PEOPLE with mental disabilities
KW - PERSONALITY disorders
KW - SUBSTANCE abuse
KW - family protective factors
KW - social ecological model
KW - substance use
N1 - Accession Number: 18675505; Min Qi Wang 1; Email Address: mqw@md.edu Matthew, Resa F. 2 Bellamy, Nikki 3 James, Syretta 4; Affiliation: 1: Professor, Department of Public and Community Health, University of Maryland, College Park, MD. 2: Project Director, McFarland Institute, Silver Spring, MD. 3: Social Science Analyst, Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, CSAP, Rockville MD. 4: Coordinator, McFarland Institute, Silver Spring, MD.; Source Info: Nov/Dec2005, Vol. 29 Issue 6, p531; Subject Term: MINORITY youth; Subject Term: DRUG use testing; Subject Term: CONTROL (Psychology); Subject Term: PEOPLE with mental disabilities; Subject Term: PERSONALITY disorders; Subject Term: SUBSTANCE abuse; Author-Supplied Keyword: family protective factors; Author-Supplied Keyword: social ecological model; Author-Supplied Keyword: substance use; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, Anna A.
AU - Kisin, Elena R.
AU - Mercer, Robert
AU - Murray, Ashley R.
AU - Johnson, Victor J.
AU - Potapovich, Alla I.
AU - Tyurina, Yulia Y.
AU - Gorelik, Olga
AU - Arepalli, Sevaram
AU - Schwegler-Berry, Diane
AU - Hubbs, Ann F.
AU - Antonini, James
AU - Evans, Douglas E.
AU - Boneki Ku
AU - Ramsey, Dawn
AU - Maynard, Andrew
AU - Kagan, Valerian E.
AU - Castranova, Vincent
AU - Baron, Paul
T1 - Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2005/11//
VL - 33
IS - 5
M3 - Article
SP - L698
EP - L708
SN - 10400605
AB - Singlewalled carbon nanotubes (SWCNT) are new materials of emerging technological importance. As SWCNT are introduced into the life cycle of commercial products, their effects on human health and environment should be addressed. We demonstrated that pharyngeal aspiration of SWCNT elicited unusual pulmonary effects in C57BL/6 mice that combined a robust but acute inflammation with early onset yet progressive fibrosis and granulomas. A dose-dependent increase in the protein, LDH, and γ-glutamyl transferase activities in bronchoalveolar lavage were found along with accumulation of 4-hydroxynonenal (oxidative biomarker) and depletion of glutathione in lungs. An early neutrophils accumulation (day I), followed by lymphocyte (day 3) and macrophage (day 7) influx, was accompanied by early elevation of proinflammatory cytokines (TNF-α, IL-1β day 1) followed by fibrogenic transforming growth factor (TGF)-β1 (peaked on day 7). A rapid progressive fibrosis found in mice exhibited two distinct morphologies: 1) SWCNT-induced granulomas mainly associated with hypertrophied epithelial cells surrounding SWCNT aggregates and 2) diffuse interstitial fibrosis and alveolar wall thickening likely associated with dispersed SWCNT. In vitro exposure of murine RAW 264.7 macrophages to SWCNT triggered TGF-β1 production similarly to zymosan but generated less TNF-α and IL-1γ. SWCNT did not cause superoxide or NO production, active SWCNT engulfment, or apoptosis in RAW 264.7 macrophages. Functional respiratory deficiencies and decreased bacterial clearance (Listeria monocytogenes) were found in mice treated with SWCNT. Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOTUBES
KW - CARBON compounds
KW - INFLAMMATION
KW - TECHNOLOGY
KW - BRONCHOALVEOLAR lavage
KW - cytokines
KW - microbial infection
KW - nanoparticles
N1 - Accession Number: 18751449; Shvedova, Anna A. 1; Email Address: AShvedova@cdc.gov Kisin, Elena R. 1 Mercer, Robert 1 Murray, Ashley R. 1 Johnson, Victor J. 1 Potapovich, Alla I. 2,3 Tyurina, Yulia Y. 2,3 Gorelik, Olga 4 Arepalli, Sevaram 4 Schwegler-Berry, Diane 1 Hubbs, Ann F. 1 Antonini, James 1 Evans, Douglas E. 5 Boneki Ku 5 Ramsey, Dawn 5 Maynard, Andrew 5 Kagan, Valerian E. 2,3 Castranova, Vincent 1,3 Baron, Paul 5; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Center for Free Radical & Antioxidant Health 3: Department of Environmental Health, University of Pittsburgh, Pittsburgh, Pennsylvania 4: Nanotube Team, GBTech, Incorporated, National Aeronautics and Space Administration-Johnson Space Center, Houston, Texas 5: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Source Info: Nov2005, Vol. 33 Issue 5, pL698; Subject Term: NANOTUBES; Subject Term: CARBON compounds; Subject Term: INFLAMMATION; Subject Term: TECHNOLOGY; Subject Term: BRONCHOALVEOLAR lavage; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: microbial infection; Author-Supplied Keyword: nanoparticles; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 11p; Illustrations: 14 Black and White Photographs, 25 Graphs; Document Type: Article
L3 - 10.1152/ajplung.00084.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106350322
T1 - Update on regulatory issues in pancreatic islet transplantation.
AU - Wonnacott K
Y1 - 2005/11//
N1 - Accession Number: 106350322. Language: English. Entry Date: 20061020. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9441347.
KW - Cell Transplantation -- Legislation and Jurisprudence
KW - Diabetes Mellitus, Type 1 -- Surgery
KW - Islets of Langerhans -- Transplantation
KW - United States Food and Drug Administration
KW - Biological Response Modifiers
KW - Clinical Trials
KW - Licensure
KW - United States
SP - 600
EP - 604
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
JA - AM J THER
VL - 12
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Over the past 12 years, the US Food and Drug Administration (FDA) has reviewed more than 40 investigational new drug applications for the use of allogeneic pancreatic islets to treat type 1 diabetes mellitus. Recent advances in islet cell isolation, transplantation, and immunosuppressive maintenance have led to multiple centers reporting promising results in the treatment of type 1 diabetes with allogeneic islet cells. The FDA held an advisory committee meeting on October 9-10, 2003, to explore the potential for licensing allogeneic islets as a therapy for severe type 1 diabetes. This article highlights the manufacturing challenges, discussed by the FDA advisory committee, that remain to be resolved before allogeneic islets can be approved for treatment of type 1 diabetes. This article also briefly addresses the challenges facing the clinical trial design of studies that could be used to support licensure.
SN - 1075-2765
AD - US Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, HFM 720, Rockville, MD 20852; wonnacott@cber.fda.gov
U2 - PMID: 16280654.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106275121
T1 - Fatal syncope-related fall after immunization.
AU - Woo EJ
AU - Ball R
AU - Braun MM
Y1 - 2005/11//
N1 - Accession Number: 106275121. Language: English. Entry Date: 20070427. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9422751.
KW - Hepatitis B Vaccines -- Adverse Effects
KW - Syncope, Vasovagal -- Chemically Induced
KW - Accidental Falls
KW - Adolescence
KW - Fatal Outcome
KW - Head Injuries -- Etiology
KW - Hepatitis B -- Prevention and Control
KW - Immunization -- Adverse Effects
KW - Male
SP - 1083
EP - 1083
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 159
IS - 11
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-222, 1401 Rockville Pike, Rockville, MD 20852
U2 - PMID: 16275804.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Parks, Christine G.
AU - Cooper, Glinda S.
T1 - Occupational exposures and risk of systemic lupus erythematosus.
JO - Autoimmunity
JF - Autoimmunity
Y1 - 2005/11//
VL - 38
IS - 7
M3 - Article
SP - 497
EP - 506
PB - Taylor & Francis Ltd
SN - 08916934
AB - This review summarizes the growing body of epidemiologic and experimental research pertaining to the relationship between SLE and occupational exposures, such as crystalline silica, solvents, and pesticides. Epidemiologic studies, using different designs in different settings, have demonstrated moderate to strong associations between occupational silica exposure and SLE. Recent experimental studies of silica in lupus-prone mice provide support for the idea that, in addition to its known adjuvant effect, silica exposure increases the generation of apoptotic material, an important source of self-antigen. Despite compelling experimental studies of the organic solvent trichloroethylene (TCE) in lupus-prone mice, there is little evidence of an overall association of SLE and occupational exposure to a broad classification of solvents in humans. However, there is a lack of data on SLE in occupational cohorts with exposures to TCE or other specific solvents. One epidemiologic study reported an association of pesticide mixing and SLE, while a recent experimental study reported accelerated disease in pesticide-treated lupus-prone mice. Other occupational exposures worth investigating include asbestos, metals, and UV radiation. Attention should also be given to the role of gene-environment interactions, which may require large, multi-site studies that collect both genetic material and occupational exposure data. The quality of exposure assessment is an important consideration in designing and evaluating these studies. The use of pre-clinical endpoints (e.g. high-titer autoantibodies) in occupational cohorts with well-characterized exposure histories may reveal occupational risk factors for autoimmunity, and may also provide baseline data for studies of determinants of progression to SLE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Autoimmunity is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - AUTOIMMUNE diseases
KW - AUTOIMMUNITY
KW - SILICA
KW - SOLVENTS
KW - PESTICIDES
KW - THRESHOLD limit values (Industrial toxicology)
KW - Crystalline silica
KW - occupational exposures
KW - pesticides
KW - SLE
KW - solvents
N1 - Accession Number: 19235893; Parks, Christine G. 1; Email Address: cqp8@cdc.gov Cooper, Glinda S. 2; Affiliation: 1: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Epidemiology Branch, National Institute of Environmental Health Sciences, MDA3-05, PO Box 12233, Durham, NC 27709, USA; Source Info: Nov2005, Vol. 38 Issue 7, p497; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: AUTOIMMUNE diseases; Subject Term: AUTOIMMUNITY; Subject Term: SILICA; Subject Term: SOLVENTS; Subject Term: PESTICIDES; Subject Term: THRESHOLD limit values (Industrial toxicology); Author-Supplied Keyword: Crystalline silica; Author-Supplied Keyword: occupational exposures; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: SLE; Author-Supplied Keyword: solvents; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 10p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/08916930500285493
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Emery, Stephen P.
AU - Levine, Richard J.
AU - Qian, Cong
AU - Ewell, Marian G.
AU - England, Lucinda J.
AU - Yu, Kai F.
AU - Catalano, Patrick M.
T1 - Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertension.
JO - BJOG: An International Journal of Obstetrics & Gynaecology
JF - BJOG: An International Journal of Obstetrics & Gynaecology
Y1 - 2005/11//
VL - 112
IS - 11
M3 - Article
SP - 1479
EP - 1485
SN - 14700328
AB - Objective To evaluate levels of 24-hour urine insulin excretion before the onset of pre-eclampsia and gestational hypertension. Design Nested case–control study within the Calcium for Preeclampsia Prevention (CPEP) study cohort. Setting Five university medical centres in the United States. Sample Cases had developed pre-eclampsia ( n= 70) or gestational hypertension ( n= 142) in the absence of gestational diabetes. Controls ( n= 429) had remained normotensive without gestational diabetes. Methods Subjects were required to have had an adequate baseline 24-hour urine collection prior to CPEP enrolment at 13–21 weeks. Controls were matched to cases by enrolment site and specimen storage time, without regard to gestational age or CPEP treatment. Adjusted mean 24-hour urine insulin excretion was, however, calculated using analysis of covariance, with adjustment models for pre-eclampsia considering body mass index, race and smoking status; and for gestational hypertension, gestational age at specimen collection, height, body mass index and smoking. Urine insulin was measured by radio-immunoassay. Main outcome measures Twenty-four-hour urine insulin excretion. Results Adjusted 24-hour urine insulin excretion at baseline (mean 17 weeks of gestation) was greater in women who developed pre-eclampsia than in normotensive controls (mean [SE]: 15.6 [1.5] vs 13.1 [1.2] × 103μIU/24 hour, P= 0.06), but not in women who developed gestational hypertension (14.7 [0.9] vs 15.0 [0.6] × 103μIU/24 hour, P= 0.79, in cases vs controls). Among women who developed pre-eclampsia, adjusted urine insulin excretion was greater than controls only in women with mild pre-eclampsia and not in severe pre-eclampsia (mild pre-eclampsia vs controls: 17.3 [2.0] vs 13.7 [1.6] × 103μIU/24 hour, P= 0.04; severe pre-eclampsia vs controls: 12.3 [2.2] vs 11.5 [1.2], P= 0.69). Conclusion The data suggest that early hyperinsulinaemia, a marker of insulin resistance, may predispose to mild pre-eclampsia. [ABSTRACT FROM AUTHOR]
AB - Copyright of BJOG: An International Journal of Obstetrics & Gynaecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINE
KW - INSULIN
KW - DIABETES
KW - PREECLAMPSIA
KW - HYPERTENSION
N1 - Accession Number: 18574455; Emery, Stephen P. 1 Levine, Richard J. 2 Qian, Cong 3 Ewell, Marian G. 4 England, Lucinda J. 2 Yu, Kai F. 5 Catalano, Patrick M. 6; Affiliation: 1: Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA 2: National Institute of Child Health and Human Development, Epidemiology Branch, US Department of Health and Human Services, Bethesda, Maryland, USA 3: Allied Technology Group, Rockville, Maryland, USA 4: The Emmes Corporation, Rockville, Maryland, USA 5: National Institute of Child Health and Human Development, Biometry and Mathematical Statistics Branch, US Department of Health and Human Services, Bethesda, Maryland, USA 6: Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA; Source Info: Nov2005, Vol. 112 Issue 11, p1479; Subject Term: URINE; Subject Term: INSULIN; Subject Term: DIABETES; Subject Term: PREECLAMPSIA; Subject Term: HYPERTENSION; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1471-0528.2005.00720.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hotchkiss, Charlotte E.
AU - Weis, Connie
AU - Blaydes, Betty
AU - Newbold, Retha
AU - Delclos, K. Barry
T1 - Multigenerational exposure to genistein does not increase bone mineral density in rats
JO - BONE
JF - BONE
Y1 - 2005/11//
VL - 37
IS - 5
M3 - Article
SP - 720
EP - 727
SN - 87563282
AB - Abstract: Genistein has been shown to prevent bone loss in ovariectomized adult rats. However, the effects of genistein on bone in developing and reproductively-intact rats have not been examined. A large multigenerational experiment involved feeding 0, 5, 100, or 500 ppm genistein in the diet to intact male and female rats from conception until either weaning, postnatal day 140, or continuously for 2 years. Vertebrae (lumbar and caudal) were collected from these animals at necropsy at 2 years of age and subjected to dual-energy x-ray absorptiometry (DXA) scanning to measure bone mineral density (BMD), bone mineral content (BMC), and bone area. Femurs were collected, and length, cross-sectional area, and cortical bone area were measured directly. Serum was collected for measurement of pyridinoline (PYD) and alkaline phosphatase (ALP). BMD was not affected by genistein in any phase of the experiment. In female rats treated continuously with genistein, BMC and bone area were reduced in the 500 ppm group compared to the 5 ppm group in the lumbar vertebrae, and in all treatment groups compared to control in the caudal vertebrae. In both males and females treated continuously, the cross-sectional area of the femur was reduced in rats treated with 500 ppm compared to those treated with 5 ppm. In female rats treated continuously, PYD was higher in the 100 and 500 ppm groups than in the 0 and 5 ppm groups. In conclusion, the effects of genistein on reproductively-intact rats were not dramatic. High dose of genistein throughout the lifespan resulted in decreased bone size, which may reduce the force required to break the bone. [Copyright &y& Elsevier]
AB - Copyright of BONE is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONES
KW - RATS
KW - ALKALINE phosphatase
KW - PHOSPHATASES
KW - THERAPEUTICS
KW - Bone development
KW - Bone mineral density
KW - Endocrine disruptors
KW - Genistein
KW - Rat
N1 - Accession Number: 18951876; Hotchkiss, Charlotte E.; Email Address: chotchkiss@nctr.fda.gov Weis, Connie 1 Blaydes, Betty 1 Newbold, Retha 1 Delclos, K. Barry 1; Affiliation: 1: The Bionetics Corporation, BIO-915, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA; Source Info: Nov2005, Vol. 37 Issue 5, p720; Subject Term: BONES; Subject Term: RATS; Subject Term: ALKALINE phosphatase; Subject Term: PHOSPHATASES; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Bone development; Author-Supplied Keyword: Bone mineral density; Author-Supplied Keyword: Endocrine disruptors; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Rat; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.bone.2005.06.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18951876&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abraham, Joseph H.
AU - Gold, Diane R.
AU - Dockery, Douglas W.
AU - Ryan, Louise
AU - Park, Ju-Hyeong
AU - Milton, Donald K.
T1 - Within-Home versus Between-Home Variability of House Dust Endotoxin in a Birth Cohort.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/11//
VL - 113
IS - 11
M3 - Article
SP - 1516
PB - Superintendent of Documents
SN - 00916765
AB - Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5-11 months. We analyzed 1,287 dust samples from the kitchen, family room, and baby’s bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Endotoxins
KW - Allergens
KW - House dust mites
KW - Households
KW - Boston (Mass.)
KW - Massachusetts
KW - dust endotoxin
KW - endotoxin
KW - intraclass correlation
KW - variance components
N1 - Accession Number: 18712702; Abraham, Joseph H. 1,2,3; Gold, Diane R. 1,2; Dockery, Douglas W. 1; Ryan, Louise 1; Park, Ju-Hyeong 4; Milton, Donald K. 1,2,5; Email Address: Donald_Milton@uml.edu; Affiliations: 1: Harvard School of Public Health, Boston, Massachusetts, USA; 2: Changing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Massachusetts, USA; 3: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 5: University of Massachusetts Lowell, Lowell, Massachusetts, USA; Issue Info: Nov2005, Vol. 113 Issue 11, p1516; Thesaurus Term: Endotoxins; Thesaurus Term: Allergens; Subject Term: House dust mites; Subject Term: Households; Subject: Boston (Mass.); Subject: Massachusetts; Author-Supplied Keyword: dust endotoxin; Author-Supplied Keyword: endotoxin; Author-Supplied Keyword: intraclass correlation; Author-Supplied Keyword: variance components; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1289/ehp.7632
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Mild, Kjell Hanson
AU - Mattsso, Mats-Olof
AU - Hardell, Lennart
AU - Bowman, Joseph D.
AU - Kundi, Michael
T1 - Occupational Carcinogens: ELF MFs.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/11//
VL - 113
IS - 11
M3 - Letter
SP - A 726
PB - Superintendent of Documents
SN - 00916765
AB - Presents a letter to the editor commenting about the list of occupational carcinogens based largely on the evaluations published by the International Agency for Research on Cancer.
KW - Carcinogens
KW - Letters to the editor
N1 - Accession Number: 18712686; Mild, Kjell Hanson 1; Mattsso, Mats-Olof 2; Hardell, Lennart 2; Bowman, Joseph D. 3; Kundi, Michael 4; Affiliations: 1: National Institute for Working Life, Umeå, Sweden; 2: Örebro University, Örebro, Sweden; 3: National Institute for Occupational, Safety and Health, Cincinnati, Ohio; 4: Medical University of Vienna, Vienna, Austria; Issue Info: Nov2005, Vol. 113 Issue 11, pA 726; Thesaurus Term: Carcinogens; Subject Term: Letters to the editor; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hayward, Douglas G.
AU - Bolger, P. Michael
T1 - Tetrachlorodibenzo-p-dioxin in baby food made from chicken produced before and after the termination of ball clay use in chicken feed in the United States
JO - Environmental Research
JF - Environmental Research
Y1 - 2005/11//
VL - 99
IS - 3
M3 - Article
SP - 307
EP - 313
SN - 00139351
AB - Abstract: Polychlorodibenzo-p-dioxin/furans were determined in chicken-containing baby foods collected from an annually conducted total diet survey by the US FDA during the last half of fiscal year (FY) 1997 through the first half of FY 1998. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was found in 8 of 11 baby food samples. The levels were between 0.025 and 0.28ngkg−1 wet wt (0.25–5ngkg−1 lipid). The mean TCDD value for chicken-containing baby food with “nondetects” equal to 0 was 1.2ngkg−1 lipid, eight times higher than the average level found during a previous survey of chicken lipid TCDD levels in 1996. All other 2,3,7,8-chlorine-substituted dibenzo-p-dioxin congeners were also found with a profile consistent with the use of ball clay in chicken feed. TCDD was not detected in any FY 2000 baby foods made with chicken, with an average limit of detection (LOD) of 0.025ngkg−1 wet wt. Whole eggs collected in 1997 from producers that never used ball clay in feed revealed TCDD measurements that were nearly all nondetects and none above the median LOD of 0.015ngkg−1 wet wt. The percentage of chickens fed ball clay in their feed was estimated to be between 2.6% and 3.5% of all chickens produced in the United States in 1997. [Copyright &y& Elsevier]
AB - Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Baby foods
KW - Ball clay
KW - Infant nutrition
KW - Diet
KW - 2
KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
KW - 3
KW - 7
KW - 8-Tetrachlorodibenzo-p-dioxin
KW - Baby food
KW - Chicken
KW - TCDD
KW - Whole eggs
N1 - Accession Number: 19062512; Hayward, Douglas G.; Email Address: dhayward@cfsan.fda.gov; Bolger, P. Michael 1; Affiliations: 1: US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Nov2005, Vol. 99 Issue 3, p307; Subject Term: Baby foods; Subject Term: Ball clay; Subject Term: Infant nutrition; Subject Term: Diet; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Author-Supplied Keyword: 3; Author-Supplied Keyword: 7; Author-Supplied Keyword: 8-Tetrachlorodibenzo-p-dioxin; Author-Supplied Keyword: Baby food; Author-Supplied Keyword: Chicken; Author-Supplied Keyword: TCDD; Author-Supplied Keyword: Whole eggs; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 212326 Shale, clay and refractory mineral mining and quarrying; NAICS/Industry Codes: 212324 Kaolin and Ball Clay Mining; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.envres.2004.11.007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shields, Anthony
AU - Briston, David
AU - Chandupatla, Samatha
AU - Douglas, Kirk A.
AU - Lawhorn-Crews, Jawana
AU - Collins, Jerry M.
AU - Mangner, Thomas J.
AU - Heilbrun, Lance K.
AU - Muzik, Otto
T1 - A simplified analysis of [18F]3′-deoxy-3′-fluorothymidine metabolism and retention.
JO - European Journal of Nuclear Medicine & Molecular Imaging
JF - European Journal of Nuclear Medicine & Molecular Imaging
Y1 - 2005/11//
VL - 32
IS - 11
M3 - Article
SP - 1269
EP - 1275
PB - Springer Science & Business Media B.V.
SN - 16197070
AB - Purpose: [18F]3′-deoxy-3′-fluorothymidine (FLT) is a thymidine analog developed for imaging tumor proliferation with positron emission tomography (PET). To quantitatively assess images, the blood activities of FLT and its glucuronidated metabolite were measured and its kinetics analyzed. This study sought to limit the number of blood samples needed to measure FLT retention. Methods: Total FLT activity was measured from 18 venous samples obtained over the first hour and dynamic imaging performed on 33 patients (average dose 350 MBq/mmol). The 5-, 10-, 30- and 60-min samples were analyzed to measure the fraction of activity in FLT and its glucuronide. HPLC analysis was compared against a two-step column (Sep-Pak) and metabolic rates measured using full and limited sampling. Probenecid (2 g, oral) was given to two patients to determine whether imaging of the liver improved. Results: At 60 min, 74% of the blood activity was unmetabolized (range 57–85%). HPLC and Sep-Pak gave comparable results (r=0.97; average difference 2.1%). For kinetic analysis, eight venous samples were sufficient to accurately measure total activity; for metabolite analysis, a single sample at 60 min yielded data with mean errors of 2.2%. The metabolic rate correlated with average SUV (r²=0.85; p=0.0002). An aorta input function gave kinetic results comparable to venous blood (r²= 0.82). Probenecid did not improve imaging of the liver. Conclusion: Dynamic measurements of FLT retention can be used to calculate metabolic rates using a limited set of samples and correction for metabolites measured in a single sample obtained at 60 min. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Nuclear Medicine & Molecular Imaging is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYMIDINE
KW - GIANT cell tumors
KW - EMISSION tomography
KW - DIAGNOSTIC imaging
KW - PYRIMIDINE nucleotides
KW - THYMINE
KW - TUMORS
KW - FLT
KW - Imaging
KW - PET
KW - Proliferation
KW - Tumor
N1 - Accession Number: 18824441; Shields, Anthony 1,2; Email Address: ShieldsA@Karmanos.org Briston, David 1,2 Chandupatla, Samatha 2 Douglas, Kirk A. 1,2 Lawhorn-Crews, Jawana 1,2 Collins, Jerry M. 3 Mangner, Thomas J. 1,4 Heilbrun, Lance K. 1,2 Muzik, Otto 1,5; Affiliation: 1: Karmanos Cancer Institute, 4100 John R Street, 4 HWCRC, Detroit, MI 48201-2013, USA 2: Department of Internal Medicine, Wayne State University, Detroit, MI, USA 3: The Food and Drug Administration, Rockville, MD, USA 4: Department of Radiology, Wayne State University, Detroit, MI, USA 5: Department of Pediatrics, Wayne State University, Detroit, MI, USA; Source Info: Nov2005, Vol. 32 Issue 11, p1269; Subject Term: THYMIDINE; Subject Term: GIANT cell tumors; Subject Term: EMISSION tomography; Subject Term: DIAGNOSTIC imaging; Subject Term: PYRIMIDINE nucleotides; Subject Term: THYMINE; Subject Term: TUMORS; Author-Supplied Keyword: FLT; Author-Supplied Keyword: Imaging; Author-Supplied Keyword: PET; Author-Supplied Keyword: Proliferation; Author-Supplied Keyword: Tumor; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 7p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1007/s00259-005-1813-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Casciano, Daniel A.
T1 - Paving the Way for Safer, More Effective Drugs, Food, and Medical Products.
JO - FDA Consumer
JF - FDA Consumer
Y1 - 2005/11//Nov/Dec2005
VL - 39
IS - 6
M3 - Article
SP - 8
EP - 11
PB - Food & Drug Administration
SN - 03621332
AB - This article deals with the emergence of technologies that relates to the discovery of and the safety assessment of the food, drugs, biologics and medical devices in the U.S. Structural genomics involves identification of genes that predispose people to various diseases, including cancer. Those working in structural genomics also study genes that may alter a person's response to a drug or other substance, resulting in an adverse event. An example of the latter is the recent episode of some patients' reaction to Vioxx (rofecoxib) and other Cox 2 inhibitors. Scientists in the pharmaceutical industry and the Food and Drug Administration are interested in predicting these adverse events prior to the approval and marketing of a drug, thus the intense interest in determining the value of these new technologies in preclinical and clinical studies.
KW - MEDICAL innovations
KW - GENOMICS
KW - DRUGS -- Side effects
KW - PHARMACEUTICAL industry
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 18937791; Casciano, Daniel A. 1; Affiliation: 1: Director, FDA's National Center for Toxicological Research, Jefferson, Ark.; Source Info: Nov/Dec2005, Vol. 39 Issue 6, p8; Subject Term: MEDICAL innovations; Subject Term: GENOMICS; Subject Term: DRUGS -- Side effects; Subject Term: PHARMACEUTICAL industry; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Illustrations: 2 Color Photographs; Document Type: Article; Full Text Word Count: 1705
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - Pharmacogenomics: On the Road to 'Personalized Medicine'
JO - FDA Consumer
JF - FDA Consumer
Y1 - 2005/11//Nov/Dec2005
VL - 39
IS - 6
M3 - Article
SP - 44
EP - 44
PB - Food & Drug Administration
SN - 03621332
AB - Discusses issues concerning pharmacogenomics and medicine. Factors contributing to the advance of pharmacogenomics; Significance of pharmacogenomics in the field of medicine; Measures taken by the U.S. Food and Drug Administration to promote the application of pharmacogenomics in the health care system.
KW - PHARMACOGENOMICS
KW - MEDICINE
KW - MEDICAL care
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 18937850; Woodcock, Janet 1; Affiliation: 1: Deputy Commissioner for Operations and Chief Operating Officer, U.S. Food and Drug Administration; Source Info: Nov/Dec2005, Vol. 39 Issue 6, p44; Subject Term: PHARMACOGENOMICS; Subject Term: MEDICINE; Subject Term: MEDICAL care; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 715
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106380130
T1 - Proteomics: moving beyond the human genome.
AU - Formanek R Jr.
Y1 - 2005/11//Nov/Dec2005
N1 - Accession Number: 106380130. Language: English. Entry Date: 20060120. Revision Date: 20151016. Publication Type: Journal Article; pictorial. Journal Subset: Consumer Health; USA. NLM UID: 0344327.
KW - Proteins
KW - Proteomics
KW - DNA
KW - Electrophoresis
KW - Genes
KW - Government Regulations
KW - Information Resources
KW - Mass Spectrometry
KW - United States Food and Drug Administration
KW - World Wide Web
SP - 18
EP - 25
JO - FDA Consumer
JF - FDA Consumer
JA - FDA CONSUM
VL - 39
IS - 6
CY - Rockville, Maryland
PB - Food & Drug Administration
AB - While the genes that compose the human genome provide the building blocks for who we are, it's the proteins that do the heavy lifting within the body.
SN - 0362-1332
AD - Director, Division of Cellular and Gene Therapies, Food and Drug Administration's Center for Biologics Evaluation and Research
U2 - PMID: 16669114.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106380152
T1 - Pharmacogenomics: on the road to 'personalized medicine'.
AU - Woodcock J
Y1 - 2005/11//Nov/Dec2005
N1 - Accession Number: 106380152. Language: English. Entry Date: 20060120. Revision Date: 20151016. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. NLM UID: 0344327.
KW - Biotechnology -- Trends
KW - Disease -- Therapy
KW - Therapeutics -- Methods
KW - Genome, Human
KW - Insurance, Health
SP - 44
EP - 44
JO - FDA Consumer
JF - FDA Consumer
JA - FDA CONSUM
VL - 39
IS - 6
CY - Rockville, Maryland
PB - Food & Drug Administration
SN - 0362-1332
AD - Deputy Commissioner for Operations, Chief Operating Officer, U.S. Food and Drug Administration
U2 - PMID: 16669118.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Whittaker, Paul
AU - San, Richard H.C.
AU - Clarke, Jane J.
AU - Seifried, Harold E.
AU - Dunkel, Virginia C.
T1 - Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2005/11//
VL - 43
IS - 11
M3 - Article
SP - 1619
EP - 1625
SN - 02786915
AB - Abstract: Chromium picolinate is one of the most commonly used chromium dietary supplements available in the United States, and it has been marketed to consumers for use in weight loss, increasing muscle mass, and lowering serum cholesterol. Chromium picolinate is a synthetic compound that provides a bioavailable form of Cr(III) that is absorbed better than dietary chromium. However, there are several reports that it can have adverse effects. In order to study the mechanism of observed cellular toxicity and mutagenicity, chromium picolinate and its component compounds, chromium (III) chloride and picolinic acid, were evaluated in Salmonella typhimurium and L5178Y mouse lymphoma cells. Neither chromium picolinate nor chromium chloride induced a mutagenic response in S. typhimurium. However, in the L5178Y mouse lymphoma mutation assay, chromium picolinate induced mutagenic responses without and with the addition of S9. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMIUM compounds
KW - CHROMIUM
KW - WEIGHT loss
KW - TOXICITY testing
KW - UNITED States
KW - 7,12-Dimethylbenzanthracene ( DMBA )
KW - Adequate Intake ( AI )
KW - Chromium
KW - Chromium picolinate
KW - Generally Recognized As Safe ( GRAS )
KW - Methyl methanesulfonate ( MMS )
KW - Mouse lymphoma
KW - Mutagenicity
KW - National Cancer Institute ( NCI )
KW - Reference Daily Intake ( RDI )
KW - Salmonella typhimurium
KW - Thymidine kinase ( TK )
KW - Trifluorothymidine ( TFT )
KW - US Food and Drug Administration ( FDA )
N1 - Accession Number: 18285671; Whittaker, Paul 1; Email Address: paul.whittaker@cfsan.fda.gov San, Richard H.C. 2 Clarke, Jane J. 2 Seifried, Harold E. 3 Dunkel, Virginia C. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, United States 2: BioReliance, Rockville, Maryland, United States 3: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; Source Info: Nov2005, Vol. 43 Issue 11, p1619; Subject Term: CHROMIUM compounds; Subject Term: CHROMIUM; Subject Term: WEIGHT loss; Subject Term: TOXICITY testing; Subject Term: UNITED States; Author-Supplied Keyword: 7,12-Dimethylbenzanthracene ( DMBA ); Author-Supplied Keyword: Adequate Intake ( AI ); Author-Supplied Keyword: Chromium; Author-Supplied Keyword: Chromium picolinate; Author-Supplied Keyword: Generally Recognized As Safe ( GRAS ); Author-Supplied Keyword: Methyl methanesulfonate ( MMS ); Author-Supplied Keyword: Mouse lymphoma; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: National Cancer Institute ( NCI ); Author-Supplied Keyword: Reference Daily Intake ( RDI ); Author-Supplied Keyword: Salmonella typhimurium; Author-Supplied Keyword: Thymidine kinase ( TK ); Author-Supplied Keyword: Trifluorothymidine ( TFT ); Author-Supplied Keyword: US Food and Drug Administration ( FDA ); NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fct.2005.05.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walls, Isabel
AU - Buchanan, Robert L.
T1 - Use of food safety objectives as a tool for reducing foodborne listeriosis
JO - Food Control
JF - Food Control
Y1 - 2005/11//
VL - 16
IS - 9
M3 - Article
SP - 795
EP - 799
SN - 09567135
AB - Abstract: Listeria monocytogenes is a foodborne pathogen that can cause listeriosis, a rare but severe disease whose invasive form has an estimated fatality rate of 20–30% of those who become ill. Typically, listeriosis occurs in individuals who have one or more underlying conditions that depress immune function, which makes them susceptible to the illness. Risk management strategies are required throughout the food chain to reduce the incidence of foodborne listeriosis. Public health objectives can be established to ensure continuous improvement in the health of the population with respect to a particular hazard and ideally should be based on an assessment of the risk to the population by the hazard. Food safety systems can be based on meeting a specific public health objective, to reduce the burden of foodborne disease. The International Commission on Microbiological Specifications for Foods has proposed the establishment of Food Safety Objectives (FSO) to provide a link between a public health objective and performance objectives and performance criteria that are established to control a foodborne hazard. An FSO can be used as a risk management tool for L. monocytogenes in ready-to-eat foods as the FSO establishes the stringency of the measures being used to control the hazard by specifying the frequency and/or cell number of L. monocytogenes in the food that should not be exceeded at the time of consumption. To establish an FSO based on a public health objective, the level of exposure that meets the public health objective must be determined. This requires an understanding of the risk characterization curve and the dose–response relationship for both the normal and the susceptible populations. This may be difficult, as there is considerable variation in the degree of susceptibility of individuals to L. monocytogenes, depending on their age, whether or not they are pregnant, and the severity of any underlying illness. It is likely that when establishing an FSO for L. monocytogenes both the normal and susceptible subpopulations will have to be considered. If the FSO is being met, there should be a concomitant reduction in illness as long as the main factors influencing the risk at the population level remain within the boundaries of the risk assessment. A reduction in illness can be measured through disease surveillance. Once a public health goal is achieved, new, technologically feasible goals should be considered to foster continuous improvement in reductions of listeriosis. Implementing effective food safety control measures, which ensure that the FSO is being met consistently, is key to reducing foodborne listeriosis. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - LISTERIOSIS
KW - BACTERIAL diseases
KW - FOOD -- Safety measures
N1 - Accession Number: 17673797; Walls, Isabel 1 Buchanan, Robert L. 2; Affiliation: 1: International Life Sciences Institute, Risk Science Institute, 1 Thomas Circle, Washington, DC 20005, USA 2: Office of Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Hwy, College Park, MD 20740, USA; Source Info: Nov2005, Vol. 16 Issue 9, p795; Subject Term: LISTERIA monocytogenes; Subject Term: LISTERIOSIS; Subject Term: BACTERIAL diseases; Subject Term: FOOD -- Safety measures; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodcont.2004.10.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=17673797&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zuvekas, Samuel H.
AU - Rupp, Agnes E.
AU - Norqulst, Grayson S.
T1 - The Impacts Of Mental Health Parity And Managed Care In One Large Employer Group: A Reexamination.
JO - Health Affairs
JF - Health Affairs
Y1 - 2005/11//Nov/Dec2005
VL - 24
IS - 6
M3 - Article
SP - 1668
EP - 1671
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Although the impacts of carve-outs to managed behavioral health care organizations (MBHOs and parity mandates on costs are largely settled in the literature, their impacts on access are less clear. Here we reexamine a study published by Samuel Zuvekas and colleagues in this journal, which found that the number of people receiving mental health/substance abuse treatment increased by almost 50 percent after the introduction of mental health parity and an MBHO. Using multivariate panel data methods, we now suggest that secular trends were largely responsible for this increase. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANAGED care plans (Medical care)
KW - MENTAL health
KW - SUBSTANCE abuse -- Treatment
KW - HEALTH facilities
KW - MEDICAL care
KW - EMPLOYERS
KW - ZUVEKAS, Samuel
N1 - Accession Number: 18845412; Zuvekas, Samuel H. 1; Email Address: szuvekas@ahrq.gov Rupp, Agnes E. 2 Norqulst, Grayson S. 3,4; Affiliation: 1: Senior Economist, Center for Financing, Access, and Cost Trends Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. 2: Chief, Mental Health Economics Research Program, National Institute of Mental Health, Bethesda, Maryland. 3: Professor, Department of Psychiatry and Human Behaviour, University of Mississippi Medical Center, Jackson. 4: Chairman, Department of Psychiatry and Human Behaviour, University of Mississippi Medical Center, Jackson.; Source Info: Nov/Dec2005, Vol. 24 Issue 6, p1668; Subject Term: MANAGED care plans (Medical care); Subject Term: MENTAL health; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: HEALTH facilities; Subject Term: MEDICAL care; Subject Term: EMPLOYERS; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; People: ZUVEKAS, Samuel; Number of Pages: 4p; Document Type: Article
L3 - 10.1377/hlthaff.24.6.1668
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18845412&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106388609
T1 - The impacts of mental health parity and managed care in one large employer group: a reexamination: an update of a 2002 study revises the authors' conclusions about changes in mental health/substance abuse specialty services use.
AU - Zuvekas SH
AU - Rupp AE
AU - Norquist GS
Y1 - 2005/11//Nov/Dec2005
N1 - Accession Number: 106388609. Language: English. Entry Date: 20060127. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Health Services Accessibility
KW - Insurance, Health
KW - Mental Health Services
KW - Case Studies
KW - Mental Health Services -- Utilization
KW - Multivariate Analysis
KW - Pearson's Correlation Coefficient
KW - Human
SP - 1668
EP - 1671
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 24
IS - 6
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Although the impacts of carve-outs to managed behavioral health care organizations (MBHOs) and parity mandates on costs are largely settled in the literature, their impacts on access are less clear. Here we reexamine a study published by Samuel Zuvekas and colleagues in this journal, which found that the number of people receiving mental health/substance abuse treatment increased by almost 50 percent after the introduction of mental health parity and an MBHO. Using multivariate panel data methods, we now suggest that secular trends were largely responsible for this increase.
SN - 0278-2715
AD - Senior Economist, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 16284042.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106388609&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hastings, Kenneth
T1 - A Review of: “Investigative Immunotoxicology”.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2005/11//Nov/Dec2005
VL - 24
IS - 6
M3 - Book Review
SP - 469
EP - 470
PB - Taylor & Francis Ltd
SN - 10915818
AB - The article reviews the book "Investigative Immunotoxicology," edited by Helen Tryphonas, Michael Fournier, Barry R. Blakely, Judit E. G. Smits, and Pauline Brousseau.
KW - IMMUNOTOXICOLOGY
KW - NONFICTION
KW - TRYPHONAS, Helen
KW - FOURNIER, Michael
KW - BLAKELY, Barry R.
KW - SMITS, Judits E. G.
KW - BROUSSEAU, Pauline
KW - INVESTIGATIVE Immunotoxicology (Book)
N1 - Accession Number: 19328624; Hastings, Kenneth 1; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research (CDER), US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Nov/Dec2005, Vol. 24 Issue 6, p469; Subject Term: IMMUNOTOXICOLOGY; Subject Term: NONFICTION; Reviews & Products: INVESTIGATIVE Immunotoxicology (Book); People: TRYPHONAS, Helen; People: FOURNIER, Michael; People: BLAKELY, Barry R.; People: SMITS, Judits E. G.; People: BROUSSEAU, Pauline; Number of Pages: 2p; Document Type: Book Review
L3 - 10.1080/10915810500366450
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19328624&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106404435
T1 - Balancing the nation's health care scorecard: the National Healthcare Quality and Disparities Reports.
AU - Kelley E
AU - McNeill D
AU - Moy E
AU - Stryer D
AU - Burgdorf J
AU - Clancy CM
Y1 - 2005/11//2005 Nov
N1 - Accession Number: 106404435. Language: English. Entry Date: 20060303. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 101238023.
KW - Quality of Health Care
KW - Reports
KW - Benchmarking
KW - Conceptual Framework
KW - Health Facility Administration
KW - Quality Improvement
KW - United States Agency for Healthcare Research and Quality
SP - 622
EP - 630
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 31
IS - 11
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - BACKGROUND: In January 2005, the U.S. Agency for Healthcare Research and Quality (AHRQ) released the congressionally mandated reports on the United States health care system--the 2004 National Healthcare Quality and Disparities Reports (NHQR and NHDR). They are intended to summarize the current state of the science of health care quality and disparities for a broad audience, including providers, consumers, researchers, and policy makers. BALANCING THE HEALTH CARE SCORECARDS: The NHQR and NHDR are designed as balanced scorecards, yet measure imbalance is evident with respect to relative attention to the quality dimensions, condition/clinical areas, and priority population. For example, heart disease and nursing home/home health each represent more than 20 measures of the total of 179 measures, whereas mental health and HIV/AIDS care are tracked with a total of six. USING THE SCORECARD FOR QUALITY IMPROVEMENT (QI): The measures making up the scorecards are derived directly from current national initiatives aimed at improving specific performance measures in hospitals, nursing homes, and home health agencies, which facilitates performance benchmarking at different levels of the health care system. CONCLUSION: Much work remains to be done if these reports are to be used to their fullest potential as balanced scorecards for the United States.
SN - 1553-7250
AD - Director, National Healthcare Quality Report, Agency for Healthcare Research and Quality, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106404435&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106404450
T1 - The CAHPS hospital survey: development, testing, and use...Consumer Assessment of Healthcare Providers and Systems
AU - Crofton C
AU - Darby C
AU - Farquhar M
AU - Clancy C
Y1 - 2005/11//2005 Nov
N1 - Accession Number: 106404450. Language: English. Entry Date: 20060303. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Instrumentation: CAHPS Hospital Survey. NLM UID: 101238023.
KW - Consumers
KW - Health Care Delivery -- Evaluation
KW - Quality of Health Care -- Evaluation
KW - Questionnaires
KW - Arizona
KW - Focus Groups
KW - Instrument Construction
KW - Instrument Validation
KW - Interviews
KW - Maryland
KW - New York
KW - Pilot Studies
KW - Reliability and Validity
KW - Surveys
KW - United States Agency for Healthcare Research and Quality
KW - Human
SP - 655
EP - 659
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 31
IS - 11
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1553-7250
AD - Senior Research Scientists, Agency for Healthcare Research and Quality, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106404450&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106384791
T1 - Working smart: in confidence. Practice toolkit: EHR implementation.
AU - Hall T
Y1 - 2005/11//2005 Nov-Dec
N1 - Accession Number: 106384791. Language: English. Entry Date: 20060127. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Computer/Information Science; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 9202024.
KW - Electronic Health Records
KW - Health Services, Indigenous
KW - Systems Implementation
SP - 59
EP - 61
JO - Journal of AHIMA
JF - Journal of AHIMA
JA - J AHIMA
VL - 76
IS - 10
CY - Chicago, Illinois
PB - American Health Information Management Association
SN - 1060-5487
AD - Health Information and Risk Management, Billings Area Indian Health Service, Billings, MT; terri.hall@mail.ihs.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106384791&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McMullen, Sarah E.
AU - Casanova, John A.
AU - Gross, Lois K.
AU - Schenck, Frank J.
T1 - Ion Chromatographic Determination of Nitrate and Nitrite in Vegetable and Fruit Baby Foods.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2005/11//Nov/Dec2005
VL - 88
IS - 6
M3 - Article
SP - 1793
EP - 1796
SN - 10603271
AB - The article discusses the development of an ion chromatographic method for the determination of nitrate and nitrite in vegetable and fruit baby foods. The higher hydrogen-ion concentration found in babies' stomachs was considered. Infants' exposure to nitrite can result in methemoglobinemia. There are indications that carcinogenic nitrosamines can be formed from nitrates at the higher hydrogen-ion concentration.
KW - CHROMATOGRAPHIC analysis
KW - NITRATES
KW - NITRITES
KW - VEGETABLES
KW - BABY foods
KW - NITROSOAMINES
N1 - Accession Number: 19188518; McMullen, Sarah E. 1; Email Address: smcmulle@ora.fda.gov Casanova, John A. 1 Gross, Lois K. 1 Schenck, Frank J. 1; Affiliation: 1: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St NE, Atlanta, GA 30309; Source Info: Nov/Dec2005, Vol. 88 Issue 6, p1793; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: NITRATES; Subject Term: NITRITES; Subject Term: VEGETABLES; Subject Term: BABY foods; Subject Term: NITROSOAMINES; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TOLLESON, WILLIAM H.
T1 - Human Melanocyte Biology, Toxicology, and Pathology.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2005/11//
VL - 23
IS - 2
M3 - Article
SP - 105
EP - 161
SN - 10590501
AB - The human melanocytes of the skin, hair, eyes, inner ears, and covering of the brain provide physiologic functions important in organ development and maintenance. Melanocytes develop from embryonic neural crest progenitors and share certain traits with other neural crest derivatives found in the adrenal medulla and peripheral nervous system. The distinctive metabolic feature of melanocytes is the synthesis of melanin pigments from tyrosine and cysteine precursors involving over 100 gene products. These complex biochemical mechanisms create inherent liabilities for melanocytic cells if intracellular systems necessary for compartmentalization, detoxification, or repair are compromised. Melanocyte disorders may involve pigmentation, sensory functions, autoimmunity, or malignancy. Environmental factors such as ultraviolet radiation and chemical exposures, combined with heritable traits, represent the principal hazards associated with melanocyte disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biology
KW - Toxicology
KW - Pathology
KW - Life sciences
KW - Medicine
KW - Melanocytes
KW - Epithelial cells
KW - Medical sciences
KW - Melanin
KW - Melanoma
KW - Ocular toxicity
KW - Ototoxicity
KW - Oxidative stress
N1 - Accession Number: 18855656; TOLLESON, WILLIAM H. 1; Email Address: wtolleson@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA; Issue Info: Nov2005, Vol. 23 Issue 2, p105; Thesaurus Term: Biology; Thesaurus Term: Toxicology; Thesaurus Term: Pathology; Thesaurus Term: Life sciences; Thesaurus Term: Medicine; Subject Term: Melanocytes; Subject Term: Epithelial cells; Subject Term: Medical sciences; Author-Supplied Keyword: Melanin; Author-Supplied Keyword: Melanoma; Author-Supplied Keyword: Ocular toxicity; Author-Supplied Keyword: Ototoxicity; Author-Supplied Keyword: Oxidative stress; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 57p; Document Type: Article
L3 - 10.1080/10590500500234970
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Curwin, Brian D.
AU - Hein, Misty J.
AU - Sanderson, Wayne T.
AU - Barr, Dana B.
AU - Heederik, Dick
AU - Reynolds, Stephen J.
AU - Ward, Elizabeth M.
AU - Alavanja, Michael C.
T1 - Urinary and hand wipe pesticide levels among farmers and nonfarmers in Iowa.
JO - Journal of Exposure Analysis & Environmental Epidemiology
JF - Journal of Exposure Analysis & Environmental Epidemiology
Y1 - 2005/11//
VL - 15
IS - 6
M3 - Article
SP - 500
EP - 508
PB - Nature Publishing Group
SN - 10534245
AB - In the spring and summer of 2001, as part of a larger study investigating farm family pesticide exposure and home contamination in Iowa, urine and hand wipe samples were collected from 24 male farmers and 23 male nonfarmer controls. On two occasions approximately 1 month apart, one hand wipe sample and an evening and morning urine sample were collected from each participant. The samples were analyzed for the parent compound or metabolites of six commonly used agricultural pesticides: alachlor, atrazine, acetochlor, metolachlor, 2,4-dichlorophenoxyacetic acid (2,4-D) and chlorpyrifos. For atrazine, acetochlor, metolachlor and 2,4-D, farmers who reported applying the pesticide had significantly higher urinary metabolite levels than nonfarmers, farmers who did not apply the pesticide, and farmers who had the pesticide commercially applied (P-value <0.05). Generally, there were no differences in urinary pesticide metabolite levels between nonfarmers, farmers who did not apply the pesticide, and farmers who had the pesticide commercially applied. Among farmers who reported applying 2,4-D themselves, time since application, amount of pesticide applied, and the number of acres to which the pesticide was applied were marginally associated with 2,4-D urine levels. Among farmers who reported applying atrazine themselves, time since application and farm size were marginally associated with atrazine mercapturate urine levels. Farmers who reported using a closed cab to apply these pesticides had higher urinary pesticide metabolite levels, although the difference was not statistically significant. Farmers who reported using closed cabs tended to use more pesticides. The majority of the hand wipe samples were nondetectable. However, detection of atrazine in the hand wipes was significantly associated with urinary levels of atrazine above the median (P-value <0.01).Journal of Exposure Analysis and Environmental Epidemiology (2005) 15, 500–508. doi:10.1038/sj.jea.7500428; published online 20 April 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Analysis & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - AGRICULTURAL chemicals
KW - POISONS
KW - FARMERS
KW - IOWA
KW - biomonitoring
KW - exposure
KW - farmer
KW - hand wipe
KW - herbicides
KW - insecticides
KW - pesticides
KW - urine
N1 - Accession Number: 18892796; Curwin, Brian D. 1; Email Address: bcurwin@cdc.gov Hein, Misty J. 1 Sanderson, Wayne T. 2 Barr, Dana B. 3 Heederik, Dick 4 Reynolds, Stephen J. 5 Ward, Elizabeth M. 6 Alavanja, Michael C. 7; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA 2: Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA 3: Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia, USA 4: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands 5: Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colarado, USA 6: Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA 7: National Cancer Institute, Bethesda, Maryland, USA; Source Info: Nov2005, Vol. 15 Issue 6, p500; Subject Term: PESTICIDES; Subject Term: AGRICULTURAL chemicals; Subject Term: POISONS; Subject Term: FARMERS; Subject Term: IOWA; Author-Supplied Keyword: biomonitoring; Author-Supplied Keyword: exposure; Author-Supplied Keyword: farmer; Author-Supplied Keyword: hand wipe; Author-Supplied Keyword: herbicides; Author-Supplied Keyword: insecticides; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: urine; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 9p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1038/sj.jea.7500428
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106387724
T1 - Family nursing: challenges and opportunities: providing leadership in family nursing from local to global health.
AU - Feetham SL
Y1 - 2005/11//
N1 - Accession Number: 106387724. Language: English. Entry Date: 20060127. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9503761.
KW - Family Nursing
KW - Leadership
KW - World Health
SP - 327
EP - 331
JO - Journal of Family Nursing
JF - Journal of Family Nursing
JA - J FAM NURS
VL - 11
IS - 4
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1074-8407
AD - Senior Program Manager, Center for Quality, Health Resources and Services Administration, U.S. Department of Health and Human Services
U2 - PMID: 16287830.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106387724&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Monheit, Alan C.
AU - Vistnes, Jessica Primoff
T1 - The demand for dependent health insurance: How important is the cost of family coverage?
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2005/11//
VL - 24
IS - 6
M3 - Article
SP - 1108
EP - 1131
SN - 01676296
AB - Abstract: From the mid-1980s to the mid-1990s, the proportion of non-elderly Americans with employment-based health insurance declined. Roughly 80% of this decline was due to the loss of coverage by dependent family members. During this period, workers became increasingly responsible for the costs of family coverage, while expanded Medicaid coverage provided low-income working families with an alternative to employment-based insurance. We examine the role of out-of-pocket premiums and expanded Medicaid eligibility in households’ demand for employment-based family coverage. Cross-sectional results reveal that demand is affected by both factors. We find that between 1987 and 1996, the increase in out-of-pocket premium costs accounted for nearly half of the decline in dependent coverage while expanded Medicaid eligibility represented 14% of the decline. [Copyright &y& Elsevier]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYER-sponsored health insurance
KW - HEALTH insurance
KW - EMPLOYEES
KW - INSURANCE premiums
KW - MEDICAID
KW - UNITED States
KW - Employment-based health insurance
KW - I10
KW - I18
KW - Medicaid
KW - Out-of-pocket premium costs
N1 - Accession Number: 19003650; Monheit, Alan C. 1; Email Address: monheiac@umdnj.edu Vistnes, Jessica Primoff 2; Email Address: jvistnes@ahrq.gov; Affiliation: 1: School of Public Health, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane West Piscataway, NJ 08554-5635, USA 2: Agency for Healthcare Research and Quality, Center for Financing, Access and Cost Trends, 540 Gaither Road Rockville, MD 20850, USA; Source Info: Nov2005, Vol. 24 Issue 6, p1108; Subject Term: EMPLOYER-sponsored health insurance; Subject Term: HEALTH insurance; Subject Term: EMPLOYEES; Subject Term: INSURANCE premiums; Subject Term: MEDICAID; Subject Term: UNITED States; Author-Supplied Keyword: Employment-based health insurance; Author-Supplied Keyword: I10; Author-Supplied Keyword: I18; Author-Supplied Keyword: Medicaid; Author-Supplied Keyword: Out-of-pocket premium costs; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 24p; Document Type: Article
L3 - 10.1016/j.jhealeco.2005.04.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106391626
T1 - Clinical factors associated with employment among people with severe mental illness: findings from the Employment Intervention Demonstration program.
AU - Razzano LA
AU - Cook JA
AU - Burke-Miller JK
AU - Mueser KT
AU - Pickett-Schenk SA
AU - Grey DD
AU - Goldberg RW
AU - Blyler CR
AU - Gold PB
AU - Leff HS
AU - Lehman AF
AU - Shafer MS
AU - Blankertz LE
AU - McFarlane WR
AU - Toprac MG
AU - Carey MA
Y1 - 2005/11//
N1 - Accession Number: 106391626. Language: English. Entry Date: 20060203. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Positive and Negative Syndrome Scale (PANSS) (Kay et al); Alcohol Use Scale and Drug Use Scale (Drake et al). Grant Information: Cooperative Agreement No. SM51820 from CMHS/SAMHSA. NLM UID: 0375402.
KW - Employment of Disabled
KW - Mental Disorders, Chronic -- Rehabilitation
KW - Adult
KW - Aged
KW - Comparative Studies
KW - Descriptive Statistics
KW - DSM
KW - Employment of Disabled -- Methods
KW - Female
KW - Logistic Regression
KW - Male
KW - Mental Disorders, Chronic -- Diagnosis
KW - Mental Disorders, Chronic -- Psychosocial Factors
KW - Middle Age
KW - Odds Ratio
KW - Outcome Assessment
KW - P-Value
KW - Pearson's Correlation Coefficient
KW - Prospective Studies
KW - Psychological Tests
KW - Rehabilitation, Vocational
KW - Scales
KW - Severity of Illness Indices
KW - Work Capacity Evaluation
KW - Workload
KW - Funding Source
KW - Human
SP - 705
EP - 713
JO - Journal of Nervous & Mental Disease
JF - Journal of Nervous & Mental Disease
JA - J NERV MENT DIS
VL - 193
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Research has shown that supported employment programs are effective in helping psychiatric outpatients achieve vocational outcomes, yet not all program participants are able to realize their employment goals. This study used 24 months of longitudinal data from a multisite study of supported employment interventions to examine the relationship of patient clinical factors to employment outcomes. Multivariate random regression analysis indicated that, even when controlling for an extensive series of demographic, study condition (experimental versus control), and work history covariates, clinical factors were associated with individuals' ability to achieve competitive jobs and to work 40 or more hours per month. Poor self-rated functioning, negative psychiatric symptoms, and recent hospitalizations were most consistently associated with failure to achieve these employment outcomes. These findings suggest ways that providers can tailor supported employment programs to achieve success with a diverse array of clinical subpopulations.
SN - 0022-3018
AD - Center on Mental Health Services Research and Policy, Dept of Psychiatry, 104 South Michigan Ave, Suite 900, Chicago, IL 60603
U2 - PMID: 16260923.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106391626&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pengfei Gao
AU - Tomasovic, Beth
T1 - Change in Tensile Properties of Neoprene and Nitrile Gloves After Repeated Exposures to Acetone and Thermal Decontamination.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2005/11//
VL - 2
IS - 11
M3 - Article
SP - 543
EP - 552
SN - 15459624
AB - This study investigated the change intensile properties of neoprene and nitrile gloves after repeated cycles of exposure to acetone, followed by thermal decontamination. The glove was exposed to acetone (outer surface in contact with chemical), subjected to thermal decontamination, and tested for the tensile strength and the ultimate elongation. Thermal decontamination was carried out inside anoven for 16 hours at 100°C. The exposureecontamination procedure was repeated for a maximum of 10 cycles. For neoprene versus acetone, theme antensile strength consistently decreased after each exposure decontamination cycle. Multiple comparisons indicated that theme antensile strengths between the new swatches and each exposure decontamination group were significantly different (p 0.05). The mean tensile strength for the new swatches was 37.1 MPa and the mean tensile strength after nine exposure decontamination cycles was 36.0 MPa, with a loss less than 3%. The largest single cycle loss for ultimate elongation occurred during the first exposure decontamination cycle for both glove materials. In our previous study, decisions regarding the effectiveness of the decontamination process were based on having no discernible change in the breakthrough time and steady-state permeation rate. The results of this study indicate that the effectiveness of the decontamination process cannot be based on permeation parameters alone but must also take into account the change in physical properties. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTIFICIAL rubber
KW - NITRILE rubber
KW - GLOVES
KW - ACETONE
KW - PROTECTIVE clothing
KW - INDUSTRIAL safety
KW - acetone
KW - chemical protective gloves
KW - decontamination
KW - degradation
KW - tensile strength
KW - ultimate elongation
N1 - Accession Number: 18518448; Pengfei Gao 1; Email Address: pcg9@cdc.gov. Tomasovic, Beth 2; Affiliation: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania 2: EG&G Technical Services, Inc, Pittsburgh, Pennsylvania; Source Info: Nov2005, Vol. 2 Issue 11, p543; Subject Term: ARTIFICIAL rubber; Subject Term: NITRILE rubber; Subject Term: GLOVES; Subject Term: ACETONE; Subject Term: PROTECTIVE clothing; Subject Term: INDUSTRIAL safety; Author-Supplied Keyword: acetone; Author-Supplied Keyword: chemical protective gloves; Author-Supplied Keyword: decontamination; Author-Supplied Keyword: degradation; Author-Supplied Keyword: tensile strength; Author-Supplied Keyword: ultimate elongation; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 325212 Synthetic Rubber Manufacturing; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 5 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106375323
T1 - Change in tensile properties of neoprene and nitrile gloves after repeated exposures to acetone and thermal decontamination.
AU - Gao P
AU - Tomasovic B
Y1 - 2005/11//
N1 - Accession Number: 106375323. Language: English. Entry Date: 20060106. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D91-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Decontamination, Hazardous Materials -- Adverse Effects
KW - Gloves -- Evaluation
KW - Ketones -- Adverse Effects
KW - Neoprene
KW - Analysis of Variance
KW - Confidence Intervals
KW - Education, Continuing (Credit)
KW - Tensile Strength -- Evaluation
KW - Human
SP - 543
EP - 552
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study investigated the change in tensile properties of neoprene and nitrile gloves after repeated cycles of exposure to acetone, followed by thermal decontamination. The glove was exposed to acetone (outer surface in contact with chemical), subjected to thermal decontamination, and tested for the tensile strength and the ultimate elongation. Thermal decontamination was carried out inside an oven for 16 hours at 100 degrees C. The exposure/decontamination procedure was repeated for a maximum of 10 cycles. For neoprene versus acetone, the mean tensile strength consistently decreased after each exposure/decontamination cycle. Multiple comparisons indicated that the mean tensile strengths between the new swatches and each exposure/decontamination group were significantly different (p < 0.05). The loss of either tensile strength or ultimate elongation was less than 23% compared with new swatches after four exposure/decontamination cycles. Swatches with out acetone exposure were then cycled through the oven in the same manner. It was found that both the heat used for thermal decontamination and acetone exposure significantly affected the tensile strength and ultimate elongation. For nitrile gloves exposed to acetone, the mean tensile strength remained virtually unchanged (p > 0.05). The mean tensile strength for the new swatches was 37.1 MPa and the mean tensile strength after nine exposure/decontamination cycles was 36.0 MPa, with a loss less than 3%. The largest single cycle loss for ultimate elongation occurred during the first exposure/decontamination cycle for both glove materials. In our previous study, decisions regarding the effectiveness of the decontamination process were based on having no discernible change in the breakthrough time and steady-state permeation rate. The results of this study indicate that the effectiveness of the decontamination process cannot be based on permeation parameters alone but must also take into account the change in physical properties.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Building 29, Pittsburgh, PA 15236; pcg9@cdc.gov
U2 - PMID: 16276643.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106375330
T1 - Head-and-face anthropometric survey of U.S. respirator users.
AU - Zhuang Z
AU - Bradtmiller B
Y1 - 2005/11//
N1 - Accession Number: 106375330. Language: English. Entry Date: 20060106. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D91-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Utilization -- United States
KW - Adult
KW - Aged
KW - Analysis of Variance
KW - Education, Continuing (Credit)
KW - Female
KW - Male
KW - Middle Age
KW - Multivariate Analysis of Variance
KW - United States
KW - Human
SP - 567
EP - 576
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Sizing data generated by the military for use in fitting respirators have been the normative basis for commercial respirator sizing. Anthropometric data developed for males and females of military age in the 1950s and 1960s are still in use today and form the only comprehensive body of information available on this subject. The twofold objective of this study was to: (1) develop an anthropometric database detailing the face size distributions of respirator users using both traditional measurement methods and three-dimensional scanning systems; and (2) use the database to establish fit test panels to be incorporated into the National Institute for Occupational Safety and Health's respirator certification and international standards. A stratified sampling plan was used with three age strata, two gender strata, and four race/ethnic group strata. The plan called for an equal sample size of 166 in each cell. Subjects were obtained at 41 sites from 8 states. In addition to height and weight, 18 facial dimensions and neck circumferences were measured using traditional methods. A total of 3997 subjects were measured using traditional methods, and 1013 of them were also scanned using a 3-D head scanner. As this was a volunteer sample, subjects did not appear in the specific proportions needed for the sampling plan. The resulting data were weighted to correspond to the U.S. population. This article presents the summary statistics for the traditional measurement data only. Multivariate analyses of the data from this study and military data revealed that using historical, military data would be inadequate for describing the anthropometric variability of the current U.S. work force.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236; zaz3@cdc.gov
U2 - PMID: 16223715.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carmona, Richard H.
T1 - Dietetics and Disability
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2005/11//
VL - 105
IS - 11
M3 - Article
SP - 1697
EP - 1697
SN - 00028223
N1 - Accession Number: 19650367; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Nov2005, Vol. 105 Issue 11, p1697; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.jada.2005.09.016
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ER -
TY - JOUR
AU - Duffy, Rosemary E.
AU - Mattson, Barbara J.
AU - Zack, Matthew
T1 - Comorbidities Among Ohio’s Nursing Home Residents With Diabetes
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
Y1 - 2005/11//
VL - 6
IS - 6
M3 - Article
SP - 383
EP - 389
SN - 15258610
AB - Objective: To determine the magnitude of diabetes mellitus among Ohio nursing home residents and the comorbid conditions affecting residents with diabetes. Research Design, Method, and Settings: In certified Ohio nursing homes during 1999, 161,723 residents were eligible for this study because they had been admitted for at least 1 day that year, had been assessed using the Centers for Medicaid and Medicare’s Minimum Data Set instrument, were 21 years old or older, and had a known sex and race. Eligible residents with diabetes were compared with those without diabetes with respect to comorbidity. Results: The 25% of residents diagnosed with diabetes were younger, more often male, and more often black than residents without this disorder. Residents with diabetes were also more likely to have cardiovascular diseases; visual problems; foot conditions, including missing limbs; and kidney failure. Residents with diabetes were less likely to have oral problems than residents without diabetes. Conclusion: The Minimum Data Set instrument identifies important comorbidities among nursing home residents with diabetes and allows their disease course to be followed longitudinally. Nursing home residents in Ohio, and presumably in other states, bear a heavy burden from diabetes and significant comorbidities. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Medical Directors Association is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETIC acidosis
KW - ENDOCRINE diseases
KW - NURSING care facilities
KW - LONG-term care of the sick
KW - comorbidities
KW - Diabetes
KW - nursing homes
N1 - Accession Number: 19012852; Duffy, Rosemary E. 1; Email Address: RDuffy@odh.ohio.gov Mattson, Barbara J. 2 Zack, Matthew 1; Affiliation: 1: Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 2: Ohio Department of Health, Columbus, OH; Source Info: Nov2005, Vol. 6 Issue 6, p383; Subject Term: DIABETIC acidosis; Subject Term: ENDOCRINE diseases; Subject Term: NURSING care facilities; Subject Term: LONG-term care of the sick; Author-Supplied Keyword: comorbidities; Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: nursing homes; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jamda.2005.04.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106182505
T1 - Comorbidities among Ohio's nursing home residents with diabetes.
AU - Duffy RE
AU - Mattson BJ
AU - Zack M
Y1 - 2005/11//
N1 - Accession Number: 106182505. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100893243.
KW - Comorbidity
KW - Diabetes Mellitus -- Epidemiology
KW - Minimum Data Set -- Evaluation
KW - Nursing Home Patients -- Ohio
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Amputation
KW - Cardiovascular Diseases
KW - Confidence Intervals
KW - Data Analysis, Computer Assisted
KW - Descriptive Statistics
KW - Female
KW - Fisher's Exact Test
KW - Foot Diseases
KW - Kidney Diseases
KW - Logistic Regression
KW - Male
KW - Mann-Whitney U Test
KW - Middle Age
KW - Mouth Diseases
KW - Nursing Homes
KW - Odds Ratio
KW - Ohio
KW - Race Factors
KW - Record Review
KW - Sex Factors
KW - Vision Disorders
KW - Human
SP - 383
EP - 389
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
JA - J AM MED DIR ASSOC
VL - 6
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To determine the magnitude of diabetes mellitus among Ohio nursing home residents and the comorbid conditions affecting residents with diabetes. RESEARCH DESIGN, METHOD, AND SETTINGS: In certified Ohio nursing homes during 1999, 161,723 residents were eligible for this study because they had been admitted for at least 1 day that year, had been assessed using the Centers for Medicaid and Medicare's Minimum Data Set instrument, were 21 years old or older, and had a known sex and race. Eligible residents with diabetes were compared with those without diabetes with respect to comorbidity. RESULTS: The 25% of residents diagnosed with diabetes were younger, more often male, and more often black than residents without this disorder. Residents with diabetes were also more likely to have cardiovascular diseases; visual problems; foot conditions, including missing limbs; and kidney failure. Residents with diabetes were less likely to have oral problems than residents without diabetes. CONCLUSION: The Minimum Data Set instrument identifies important comorbidities among nursing home residents with diabetes and allows their disease course to be followed longitudinally. Nursing home residents in Ohio, and presumably in other states, bear a heavy burden from diabetes and significant comorbidities.
SN - 1525-8610
AD - Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA.
U2 - PMID: 16286059.
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DB - rzh
ER -
TY - JOUR
AU - Yedavalli, Venkat S. R. K.
AU - Hsiu-Ming Shih
AU - Yu-Ping Chiang
AU - Chun-Yi Lu
AU - Chang, Luan-Yin
AU - Mao-Yuan Chen
AU - Che-Yen Chuang
AU - Dayton, Andrew I.
AU - Kuan-Teh Jeang
AU - Li-Min Huang
T1 - Human Immunodeficiency Virus Type 1 Vpr Interacts with Antiapoptotic Mitochondrial Protein HAX-1.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/11//
VL - 79
IS - 21
M3 - Article
SP - 13735
EP - 13746
SN - 0022538X
AB - Human immunodeficiency virus type 1 viral protein R (Vpr) is required for viral pathogenesis and has been implicated in T-cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential. To understand better Vpr-mitochondria interaction, we report here the identification of antiapoptotic mitochondrial protein HAX-1 as a novel Vpr target. We show that Vpr and HAX-1 physically associate with each other. Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - VIRAL proteins
KW - T cells
KW - APOPTOSIS
KW - MITOCHONDRIAL membranes
KW - CELL membranes
KW - HTLV (Viruses)
KW - BIOLOGICAL membranes
N1 - Accession Number: 18709361; Yedavalli, Venkat S. R. K. 1 Hsiu-Ming Shih 2 Yu-Ping Chiang 3 Chun-Yi Lu 3 Chang, Luan-Yin 3 Mao-Yuan Chen 4 Che-Yen Chuang 4 Dayton, Andrew I. 5 Kuan-Teh Jeang 1; Email Address: kj7e@nih.gov Li-Min Huang 3; Email Address: lmhuang@ha.mc.ntu.edu.tw; Affiliation: 1: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Maryland 20892-0460 2: Institute of Biomedical Sciences, Academia Sinica, National Taiwan University Hospital, Taipe, Taiwan 100 3: Department of Pediatrics, National Taiwan University Hospital, Taipe, Taiwan 100 4: Internal Medicine, National Taiwan University Hospital, Taipe, Taiwan 100 5: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892-0460; Source Info: Nov2005, Vol. 79 Issue 21, p13735; Subject Term: HIV (Viruses); Subject Term: VIRAL proteins; Subject Term: T cells; Subject Term: APOPTOSIS; Subject Term: MITOCHONDRIAL membranes; Subject Term: CELL membranes; Subject Term: HTLV (Viruses); Subject Term: BIOLOGICAL membranes; Number of Pages: 12p; Illustrations: 4 Color Photographs, 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1128/JVI.79.21.13735-13746.2005
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DB - aph
ER -
TY - JOUR
AU - Machado, Marcos O.
AU - Hirata, Rosario D. C.
AU - Sellitti, Donald F.
AU - Iotti, Roberto
AU - Iotti, Alejandro
AU - Cusumano, Ana M.
AU - Riordan, Gavin P.
AU - Coschigano, Karen T.
AU - Kopchick, John J.
AU - Zuhl, Irina
AU - Nga Nguyen
AU - Hirata, Mario H.
AU - Doi, Sonia Q.
T1 - Growth hormone promotes glomerular lipid accumulation in bGH mice.
JO - Kidney International
JF - Kidney International
Y1 - 2005/11//
VL - 68
IS - 5
M3 - Article
SP - 2019
EP - 2028
SN - 00852538
AB - Background. Bovine growth hormone (bGH) transgenic mice develop progressive glomerulosclerosis and exhibit abnormalities in hepatic lipid metabolism. We have previously shown that growth hormone up-regulates the low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) in mouse mesangial cells. However, a role of lipid abnormalities in bGH kidney disease has not yet been demonstrated. Methods. Groups of bGH mice (5 and 11 months old) presenting with, respectively, moderate and severe degrees of glomerulosclerosis were compared to age-matched controls. Neutral lipid content in kidney cortex was determined by oil red-O staining, serum cholesterol, and triglycerides by enzymatic assays, relative mRNA expression of LDL receptors, HMGR, and scavenger receptor by real-time reverse transcription-polymerase chain reaction (RT-PCR), and HMGR protein expression by immunoblotting. Two younger (5 and 12 weeks old) groups of mice were used to study scavenger receptor expression at earlier time points. Results. Serum cholesterol was significantly increased in bGH mice at 5 months, but triglycerides were lower than control levels at both 5 and 11 months. Renal cortex HMGR expression was elevated at the mRNA but not at the protein level in the 11-month-old bGH group compared to controls. However, glomerular neutral lipid staining and scavenger receptor mRNA expression were markedly increased in all bGH mice, including those at 5 weeks of age compared to respective controls. Conclusion. The bGH mouse exhibits an increased mesangial lipid content and elevated scavenger receptor mRNA expression as early as at 5 weeks of age, suggesting that an increased kidney uptake of oxidized LDL could play a role in the development of glomerulosclerosis in this mouse model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOMATOTROPIN
KW - CHOLESTEROL
KW - TRIGLYCERIDES
KW - LIPOPROTEINS
KW - LOW density lipoproteins
KW - BLOOD lipoproteins
KW - BOVINE somatotropin
KW - LIPID metabolism
KW - cholesterol
KW - glomerulosclerosis
KW - HMG-CoA reductase
KW - low-density lipoprotein receptor
KW - real time RT-PCR
KW - scavenger receptor
KW - triglycerides
N1 - Accession Number: 18473742; Machado, Marcos O. 1,2,3,4,5,6,7 Hirata, Rosario D. C. 1,2,3,4,5,6,7 Sellitti, Donald F. 1,2,3,4,5,6,7 Iotti, Roberto 1,2,3,4,5,6,7 Iotti, Alejandro 1,2,3,4,5,6,7 Cusumano, Ana M. 1,2,3,4,5,6,7 Riordan, Gavin P. 1,2,3,4,5,6,7 Coschigano, Karen T. 1,2,3,4,5,6,7 Kopchick, John J. 1,2,3,4,5,6,7 Zuhl, Irina 1,2,3,4,5,6,7 Nga Nguyen 1,2,3,4,5,6,7 Hirata, Mario H. 1,2,3,4,5,6,7 Doi, Sonia Q. 1,2,3,4,5,6,7; Email Address: sdoi@usush.mil; Affiliation: 1: Uniformed Services University, Bethesda, Maryland 2: School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil 3: Department of Pathology CEMIC, Buenos Aires, Argentina 4: Nephrology Section, CEMIC, Buenos Aires, Argentina 5: Section on Structural Cell Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 6: Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 7: CBER, Food and Drug Administration, Bethesda, Maryland; Source Info: Nov2005, Vol. 68 Issue 5, p2019; Subject Term: SOMATOTROPIN; Subject Term: CHOLESTEROL; Subject Term: TRIGLYCERIDES; Subject Term: LIPOPROTEINS; Subject Term: LOW density lipoproteins; Subject Term: BLOOD lipoproteins; Subject Term: BOVINE somatotropin; Subject Term: LIPID metabolism; Author-Supplied Keyword: cholesterol; Author-Supplied Keyword: glomerulosclerosis; Author-Supplied Keyword: HMG-CoA reductase; Author-Supplied Keyword: low-density lipoprotein receptor; Author-Supplied Keyword: real time RT-PCR; Author-Supplied Keyword: scavenger receptor; Author-Supplied Keyword: triglycerides; Number of Pages: 10p; Illustrations: 1 Color Photograph, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1523-1755.2005.00656.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, Allison M.
AU - Boucher, Philip E.
AU - Williams, Corinne L.
AU - Stibitz, Scott
AU - Cotter, Peggy A.
T1 - Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2005/11//
VL - 58
IS - 3
M3 - Article
SP - 700
EP - 713
PB - Wiley-Blackwell
SN - 0950382X
AB - To investigate the mechanism by which the Bordetella BvgAS phosphorelay controls expression of at least three distinct phenotypic phases, we isolated and characterized two B. pertussis mutants that were able to express Bvg– and Bvgi phase phenotypes but not Bvg+ phase phenotypes. In both cases, the mutant phenotype was due to a single nucleotide change in bvgA resulting in a single amino acid substitution in BvgA. In vitro phosphorylation assays showed that BvgA containing the T194M substitution was significantly impaired in its ability to use either BvgS or acetyl phosphate as a substrate for phosphorylation. Binding studies indicated that this mutant protein was able to bind an oligonucleotide containing a high-affinity BvgA binding site in a manner similar to wild-type BvgA, but was defective for binding the fhaB promoter in the absence of RNA polymerase (RNAP). By contrast, BvgA containing the R152H substitution had wild-type phosphorylation properties but was severely defective in its ability to bind either the high-affinity BvgA binding site-containing oligonucleotide or the fhaB promoter by itself. Both mutant BvgA proteins were able to bind the fhaB promoter in the presence of RNAP however, demonstrating the profound effect that RNAP has on stabilizing the ternary complexes between promoter DNA, BvgA and RNAP. Our results are consistent with the hypothesis that BvgAS controls expression of multiple phenotypic phases by adjusting the intracellular concentration of BvgA∼P and they demonstrate the additive nature of BvgA binding site affinity and protein–protein interactions at different Bvg-regulated promoters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA
KW - BRUCELLACEAE
KW - DNA
KW - GENE expression
KW - RNA polymerases
KW - TRANSFERASES
KW - BACTERIAL genetics
N1 - Accession Number: 18526980; Jones, Allison M. 1 Boucher, Philip E. 2 Williams, Corinne L. 1 Stibitz, Scott 2 Cotter, Peggy A. 1; Email Address: cotter@lifesci.ucsb.edu; Affiliation: 1: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93109-9610, USA 2: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Nov2005, Vol. 58 Issue 3, p700; Subject Term: BORDETELLA; Subject Term: BRUCELLACEAE; Subject Term: DNA; Subject Term: GENE expression; Subject Term: RNA polymerases; Subject Term: TRANSFERASES; Subject Term: BACTERIAL genetics; Number of Pages: 14p; Illustrations: 1 Black and White Photograph, 7 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2958.2005.04875.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18526980&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rapoport, Aaron P.
AU - Stadtmauer, Edward A.
AU - Aqui, Nicole
AU - Badros, Ashraf
AU - Cotte, Julio
AU - Chrisley, Lisa
AU - Veloso, Elizabeth
AU - Zhaohui Zheng
AU - Westphal, Sandra
AU - Mair, Rebecca
AU - Chi, Nina
AU - Ratterree, Bashi
AU - Pochran, Mary Francis
AU - Natt, Sabrina
AU - Hinkle, Joanne
AU - Sickles, Cheryl
AU - Sohal, Ambika
AU - Ruehle, Kathleen
AU - Lynch, Christian
AU - Lei Zhang
T1 - Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2005/11//
VL - 11
IS - 11
M3 - Article
SP - 1230
EP - 1237
PB - Nature Publishing Group
SN - 10788956
AB - Immunodeficiency is a barrier to successful vaccination in individuals with cancer and chronic infection. We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. Combination immunotherapy consisting of a single early post-transplant infusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-transplant booster immunizations improved the severe immunodeficiency associated with high-dose chemotherapy and led to the induction of clinically relevant immunity in adults within a month after transplantation. Immune assays showed accelerated restoration of CD4 T-cell numbers and function. Early T-cell infusions also resulted in significantly improved T-cell proliferation in response to antigens that were not contained in the vaccine, as assessed by responses to staphylococcal enterotoxin B and cytomegalovirus antigens (P < 0.05). In the setting of lymphopenia, combined vaccine therapy and adoptive T-cell transfer fosters the development of enhanced memory T-cell responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNITY
KW - CANCER
KW - VACCINATION
KW - T cells
KW - IMMUNODEFICIENCY
N1 - Accession Number: 18750981; Rapoport, Aaron P. 1 Stadtmauer, Edward A. 2 Aqui, Nicole 2 Badros, Ashraf 1 Cotte, Julio 2 Chrisley, Lisa 1 Veloso, Elizabeth 2 Zhaohui Zheng 2 Westphal, Sandra 1 Mair, Rebecca 2 Chi, Nina 2 Ratterree, Bashi 1 Pochran, Mary Francis 1 Natt, Sabrina 1 Hinkle, Joanne 2 Sickles, Cheryl 2 Sohal, Ambika 2 Ruehle, Kathleen 1 Lynch, Christian 3 Lei Zhang 1; Affiliation: 1: University of Maryland Greenebaum Cancer Center and Center for Vaccine Development, 22 South Greene Street Baltimore, Maryland 21201, USA 2: Abramson Cancer Center, University of Pennsylvania, 421 Curie Boulevard Philadelphia, Pennsylvania 19104, USA 3: Food and Drug Administration, Center for Biologics Evolution and Research, 1401 Rockville Pike, Rockville, Maryland 20852, USA; Source Info: Nov2005, Vol. 11 Issue 11, p1230; Subject Term: IMMUNITY; Subject Term: CANCER; Subject Term: VACCINATION; Subject Term: T cells; Subject Term: IMMUNODEFICIENCY; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1038/nm1310
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tamura, Yuichi
AU - Hamajima, Kenji
AU - Matsui, Kiyohiko
AU - Yanoma, Shunsuke
AU - Narita, Masato
AU - Tajima, NobuyoshiI
AU - Xin, Ke-Qin
AU - Klinman, Dennis
AU - Okuda, Kenji
T1 - The F(ab′)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain
JO - Neurobiology of Disease
JF - Neurobiology of Disease
Y1 - 2005/11//
VL - 20
IS - 2
M3 - Article
SP - 541
EP - 549
SN - 09699961
AB - Abstract: This work examines whether administering the F(ab´)2 fragment of an IgG1 monoclonal antibody (mAb) targeting the N-terminal 1–13 amino acids of the β-amyloid peptide (Aβ mAb) reduces amyloid deposition in Alzheimer''s disease (AD). The F(ab′)2 fragment was injected intraperitoneally or intracranially into Tg2576 mice, a murine model of human AD. Both routes of administration significantly reduced Aβ plaque formation in the brain, as determined immunohistochemically and by monitoring levels of Aβ1–40 and Aβ1–42 peptide. Use of the F(ab′)2 fragment significantly reduced phagocytic infiltration in the CNS when compared to intact mAb. Since IgG1 Abs do not fix complement, these findings suggest that effective in vivo clearance of amyloid deposits can be achieved without stimulation of FcR-reactive phagocytes or activation of the complement cascade. [Copyright &y& Elsevier]
AB - Copyright of Neurobiology of Disease is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - MOLECULAR cloning
KW - MONOCLONAL antibodies
KW - IMMUNE system
KW - β-amyloid peptide (Aβ)
KW - Alzheimer's disease
KW - Amyloid plaque
KW - Anti-Aβ monoclonal antibody
KW - F(ab′)2 fragment
KW - IgG1 isotype
KW - Microglia
KW - Passive immunization
KW - Tg2576 mouse
N1 - Accession Number: 18953559; Tamura, Yuichi 1,2 Hamajima, Kenji 2 Matsui, Kiyohiko 2 Yanoma, Shunsuke 2 Narita, Masato 3 Tajima, NobuyoshiI 2 Xin, Ke-Qin 2 Klinman, Dennis 4 Okuda, Kenji 2; Email Address: kokuda@med.yokohama-cu.ac.jp; Affiliation: 1: Nichiiko Pharmaceutical, Co., Ltd, Toyama, Japan 2: Department of Bacteriology, Yokohama City University School of Medicine, Yokohama, Japan 3: Department of Oral Surgery, Tokyo Dental College, Chiba, Japan 4: Center for Biologics Evaluation and Research, Food and Drug Administration, MD 20587-0001, USA; Source Info: Nov2005, Vol. 20 Issue 2, p541; Subject Term: GLYCOPROTEINS; Subject Term: MOLECULAR cloning; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNE system; Author-Supplied Keyword: β-amyloid peptide (Aβ); Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: Amyloid plaque; Author-Supplied Keyword: Anti-Aβ monoclonal antibody; Author-Supplied Keyword: F(ab′)2 fragment; Author-Supplied Keyword: IgG1 isotype; Author-Supplied Keyword: Microglia; Author-Supplied Keyword: Passive immunization; Author-Supplied Keyword: Tg2576 mouse; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.nbd.2005.04.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106416616
T1 - Guest editorial: intersections for mutual success in nursing and health services research.
AU - Clancy C
AU - Sharp BAC
AU - Hubbard HB
Y1 - 2005/11//
N1 - Accession Number: 106416616. Language: English. Entry Date: 20060331. Revision Date: 20150818. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0401075.
KW - Health Services Research
KW - Nursing Administration Research
KW - Cooperative Behavior
KW - Health Care Errors -- Prevention and Control
KW - Interinstitutional Relations
KW - Organizational Objectives
KW - Quality Assurance -- Administration
KW - United States Agency for Healthcare Research and Quality -- Administration
SP - 263
EP - 265
JO - Nursing Outlook
JF - Nursing Outlook
JA - NURS OUTLOOK
VL - 53
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 0029-6554
AD - Director, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 16360691.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106416616&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hein, Gayle L.
AU - Storey, Maureen L.
AU - White, John S.
AU - Lineback, David R.
T1 - Highs and Lows of High Fructose Corn Syrup: A Report From the Center for Food and Nutrition Policy and Is Ceres® Workshop.
JO - Nutrition Today
JF - Nutrition Today
Y1 - 2005/11//Nov/Dec2005
VL - 40
IS - 6
M3 - Article
SP - 253
EP - 256
SN - 0029666X
AB - The article presents an excerpt of the presentations and discussions from the Ceres Workshop on the "Highs and Lows of High Fructose Corn Syrup" that was convened on May 10, 2004.
KW - WORKSHOPS (Adult education)
KW - CORN syrup
N1 - Accession Number: 25583477; Hein, Gayle L. 1 Storey, Maureen L. 1; Email Address: storey@umd.edu White, John S. 2 Lineback, David R. 3; Affiliation: 1: Center for Food and Nutrition Policy, Virginia Tech—National Capital Region, Alexandria, VA 2: White Technical Research, Argenta, IL 3: University of Maryland/US Food and Drug Administration, Joint Institute for Food Safety and Applied Nutrition, College Park, MD; Source Info: Nov/Dec2005, Vol. 40 Issue 6, p253; Subject Term: WORKSHOPS (Adult education); Subject Term: CORN syrup; NAICS/Industry Codes: 311221 Wet Corn Milling; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, M.-L.
AU - Z.-E. Wu
AU - Q.-G. Du
AU - Petsonk, E. L.
AU - K.-L. Peng
AU - Y.-D. Li
AU - S.-K. Li
AU - G.-H. Han
AU - Atffield, M. D.
T1 - A prospective cohort study among new Chinese coal miners: the early pattern of lung function change.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2005/11//
VL - 62
IS - 11
M3 - Article
SP - 800
EP - 805
SN - 13510711
AB - Aims: To investigate the early pattern of longitudinal change in forced expiratory volume in 1 second (FEV1) among new Chinese coal miners, and the relation between coal mine dust exposure and the decline of lung function. Methods: The early pattern of lung function changes in 317 newly hired Chinese underground coal miners was compared to 132 referents. This three year prospective cohort study involved a pre-employment and 15 follow up health surveys, including a questionnaire and spirometry tests. Twice a month, total and respirable dust area sampling was done. The authors used a two stage analysis and a linear mixed effects model approach to analyse the longitudinal spirometry data, and to investigate the changes in FEV1 over time, controlling for age, height, pack years of smoking, mean respirable dust concentration, the room temperature during testing, and the group ×time interaction terms. Results: FEV1 change over time in new miners is non-linear. New miners experience initial rapid FEV1 declines, primarily during the first year of mining, little change during the second year, and partial recovery during the third year. Both linear and quadratic time trends in FEV1 change are highly significant. Smoking miners lost more FEV1 than non-smokers. Referents, all age less than 20 years, showed continued lung growth, whereas the miners who were under age 20 exhibited a decline in FEV1. Conclusion: Dust and smoking affect lung function in young, newly hired Chinese coal miners. FEV1 change over the first three years of employment is non-linear. The findings have implications for both methods and interpretation of medical screening in coal mining and other dusty work: during the first several years of employment more frequent testing may be desirable, and caution is required in interpreting early FEV1 declines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Mine dusts
KW - Smoking
KW - Coal miners
KW - Lung diseases
KW - Longitudinal method
KW - China
N1 - Accession Number: 18939589; Wang, M.-L. 1; Email Address: mlw4@cdc.edu; Z.-E. Wu 2; Q.-G. Du 3; Petsonk, E. L. 1; K.-L. Peng 2; Y.-D. Li 3; S.-K. Li 3; G.-H. Han 3; Atffield, M. D. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV, USA.; 2: Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China.; 3: Xuzhou Mining Group Company Ltd., Xuzhou, Jiangsu, People's Republic of China.; Issue Info: Nov2005, Vol. 62 Issue 11, p800; Thesaurus Term: DISEASES; Thesaurus Term: Mine dusts; Thesaurus Term: Smoking; Subject Term: Coal miners; Subject Term: Lung diseases; Subject Term: Longitudinal method; Subject: China; Number of Pages: 6p; Illustrations: 4 Charts, 5 Graphs; Document Type: Article
L3 - 10.1136/oem.2005.020271
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18939589&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106411012
T1 - A prospective cohort study among new Chinese coal miners: the early pattern of lung function change.
AU - Wang M
AU - Wu Z
AU - Du Q
AU - Petsonk EL
AU - Peng K
AU - Li Y
AU - Li S
AU - Han G
AU - Atffield MD
Y1 - 2005/11//
N1 - Accession Number: 106411012. Language: English. Entry Date: 20060317. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Supported by the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. NLM UID: 9422759.
KW - Lung -- Physiology
KW - Mining -- China
KW - Occupational Exposure -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - China
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Dust -- Analysis
KW - Environmental Monitoring -- Methods
KW - Epidemiological Research
KW - Forced Expiratory Volume
KW - Inspiration, Respiratory
KW - Prospective Studies
KW - Seasons
KW - Smoking -- Physiopathology
KW - Spirometry -- Methods
KW - T-Tests
KW - Funding Source
KW - Human
SP - 800
EP - 805
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 62
IS - 11
PB - BMJ Publishing Group
AB - AIMS: To investigate the early pattern of longitudinal change in forced expiratory volume in 1 second (FEV1) among new Chinese coal miners, and the relation between coal mine dust exposure and the decline of lung function. METHODS: The early pattern of lung function changes in 317 newly hired Chinese underground coal miners was compared to 132 referents. This three year prospective cohort study involved a pre-employment and 15 follow up health surveys, including a questionnaire and spirometry tests. Twice a month, total and respirable dust area sampling was done. The authors used a two stage analysis and a linear mixed effects model approach to analyse the longitudinal spirometry data, and to investigate the changes in FEV1 over time, controlling for age, height, pack years of smoking, mean respirable dust concentration, the room temperature during testing, and the groupxtime interaction terms. RESULTS: FEV1 change over time in new miners is non-linear. New miners experience initial rapid FEV1 declines, primarily during the first year of mining, little change during the second year, and partial recovery during the third year. Both linear and quadratic time trends in FEV1 change are highly significant. Smoking miners lost more FEV1 than non-smokers. Referents, all age less than 20 years, showed continued lung growth, whereas the miners who were under age 20 exhibited a decline in FEV1. CONCLUSION: Dust and smoking affect lung function in young, newly hired Chinese coal miners. FEV1 change over the first three years of employment is non-linear. The findings have implications for both methods and interpretation of medical screening in coal mining and other dusty work: during the first several years of employment more frequent testing may be desirable, and caution is required in interpreting early FEV1 declines.
SN - 1351-0711
AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Mail Stop H-G900.2, Morgantown, WV 26505; mlw4@cdc.gov
U2 - PMID: 16234407.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hunter, Wanda M.
AU - Helou, Samah
AU - Saluja, Gitanjali
AU - Runyan, Carol W.
AU - Coyne-Beasley, Tamera
T1 - Injury Prevention Advice in Top-Selling Parenting Books.
JO - Pediatrics
JF - Pediatrics
Y1 - 2005/11//
VL - 116
IS - 5
M3 - Article
SP - 1080
EP - 1088
SN - 00314005
AB - Objective. Parenting books are a commonly used source of information on how to keep children and adolescents safe from injuries, the leading cause of death and disability for children aged 1 to 18 years. The content and the quality of the messages contained in these books have not been evaluated formally. The objective of this study was to determine the quantity and the quality of injury prevention messages contained in popular parenting books. Methods. Top-selling parenting books for 2 major booksellers were reviewed to determine the presence and the accuracy of injury prevention messages as compared with those recommended by the American Academy of Pediatrics (AAP) through The Injury Prevention Program (TIPP) for younger children, aged 0 to 12 years, and the American Medical Association (AMA) through its Parent Package for the safety of adolescents. Results. Forty-six parenting books were reviewed, including 41 with messages related to younger children and 19 with messages related to adolescents. These books varied widely with regard to the number of injury prevention messages included. Although some books covered the great majority of TIPP messages for parents of young children, others included very few. In the case of books that address safety for adolescents, no book had more than half of the messages recommended by the AMA. Prevention of burns and motor vehicle injury were the most commonly addressed injury prevention topics in the books focused on younger children, whereas gun safety was the most prevalent injury prevention topic in books that focused on adolescents. Books that were authored by physicians addressed more of the recommended topics and messages than books that were written by authors from other professional backgrounds. The quality of messages was good, ie, consistent with the advice given by the AAP and the AMA. In only a few cases, the parenting books gave injury prevention advice that was inconsistent with recommendations. Conclusions. Overall, books on parenting adolescents are less likely to contain injury prevention messages than those that address younger children. However, the most frequent injury prevention messages for parents of adolescents describe strategies to prevent firearm injury, a leading cause of death for children in this age group. More emphasis should be placed on prevention of motor vehicle injuries, especially as relates to adolescents. Pediatricians and primary care physicians need to be aware of the strengths and weaknesses of parenting manuals in providing adequate guidance related to injury prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL literature
KW - PARENTING
KW - BOOKS
KW - CHILDREN -- Wounds & injuries
KW - PREVENTIVE medicine
KW - anticipatory guidance
KW - injury prevention
KW - parenting books
KW - safety
KW - TIPP
N1 - Accession Number: 18800377; Hunter, Wanda M. 1 Helou, Samah 2 Saluja, Gitanjali 3 Runyan, Carol W. 4,5; Email Address: carol_runyan@unc.edu Coyne-Beasley, Tamera 5,6; Affiliation: 1: The University of North Carolina Injury Prevention Research Center and Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 2: The University of North Carolina Injury Prevention Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 3: National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 4: The University of North Carolina Injury Prevention Research Center and Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 5: Department of Health Behavior and Health Education, University of North Carolina School of Public Health, Chapel Hill, North Carolina 6: The University of North Carolina Injury Prevention Research Center and Departments of Pediatrics and Internal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Source Info: Nov2005, Vol. 116 Issue 5, p1080; Subject Term: MEDICAL literature; Subject Term: PARENTING; Subject Term: BOOKS; Subject Term: CHILDREN -- Wounds & injuries; Subject Term: PREVENTIVE medicine; Author-Supplied Keyword: anticipatory guidance; Author-Supplied Keyword: injury prevention; Author-Supplied Keyword: parenting books; Author-Supplied Keyword: safety; Author-Supplied Keyword: TIPP; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 451211 Book Stores; NAICS/Industry Codes: 451310 Book stores and news dealers; Number of Pages: 9p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
L3 - 10.1542/peds.2004-1757
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kogan, Michael D.
AU - Newacheck, Paul W.
AU - Honberg, Lynda
AU - Strickland, Bonnie
T1 - Association Between Underinsurance and Access to Care Among Children With Special Health Care Needs in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2005/11//
VL - 116
IS - 5
M3 - Article
SP - 1162
EP - 1169
SN - 00314005
AB - Objective. To examine the impact of underinsurance on access to care among children with special health care needs (CSHCN) in the United States. Methods. Interviews were conducted by telephone with the families of 38 866 CSHCN who were younger than 18 years using the 2001 National Survey of Children With Special Health Care Needs. The prevalence of underinsurance and its relationship to access to care and family financial problems was examined in this cross-sectional analysis. CSHCN were classified as underinsured when coverage was deemed inadequate to meet the child's needs. Results. An estimated 12.8% of US children experienced a special health care need in 2001. Although 95% of CSHCN had some type of insurance coverage at the time of the interview, 32% were classified as underinsured. Underinsured CSHCN were disproportionately represented in low-income families and were significantly more likely than fully insured children to have unmet health needs, and their families were more likely to report difficulty in obtaining specialty referrals, experience financial problems, and report that the child's condition caused family members to reduce or stop work. Underinsured CSHCN seemed to be somewhat better off than CSHCN with no insurance coverage on these measures. Conclusions. Underinsured CSHCN represent an important and largely hidden underserved population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UNDERINSURANCE
KW - CHILD health services
KW - CHILD care
KW - JUVENILE diseases
KW - PEDIATRICS
KW - access to care
KW - children with special health care needs
KW - disability
KW - insurance
KW - national estimates
KW - underinsurance
N1 - Accession Number: 18800397; Kogan, Michael D. 1; Email Address: mkogan@hrsa.gov Newacheck, Paul W. 2 Honberg, Lynda 1 Strickland, Bonnie 1; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: University of California, Institute for Health Policy Studies and Department of Pediatrics, San Francisco, California; Source Info: Nov2005, Vol. 116 Issue 5, p1162; Subject Term: UNDERINSURANCE; Subject Term: CHILD health services; Subject Term: CHILD care; Subject Term: JUVENILE diseases; Subject Term: PEDIATRICS; Author-Supplied Keyword: access to care; Author-Supplied Keyword: children with special health care needs; Author-Supplied Keyword: disability; Author-Supplied Keyword: insurance; Author-Supplied Keyword: national estimates; Author-Supplied Keyword: underinsurance; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1542/peds.2004-2432
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106373968
T1 - Association between underinsurance and access to care among children with special health care needs in the United States.
AU - Kogan MD
AU - Newacheck PW
AU - Honberg L
AU - Strickland B
Y1 - 2005/11//
N1 - Accession Number: 106373968. Language: English. Entry Date: 20060106. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child, Medically Fragile
KW - Health Services Accessibility
KW - Health Services -- Utilization
KW - Insurance, Health
KW - Medically Uninsured
KW - Adolescence
KW - Bivariate Statistics
KW - Child
KW - Child, Preschool
KW - Conceptual Framework
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Female
KW - Infant, Newborn
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Random Sample
KW - United States
KW - Human
SP - 1162
EP - 1169
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 116
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To examine the impact of underinsurance on access to care among children with special health care needs (CSHCN) in the United States. METHODS: Interviews were conducted by telephone with the families of 38866 CSHCN who were younger than 18 years using the 2001 National Survey of Children With Special Health Care Needs. The prevalence of underinsurance and its relationship to access to care and family financial problems was examined in this cross-sectional analysis. CSHCN were classified as underinsured when coverage was deemed inadequate to meet the child's needs. RESULTS: An estimated 12.8% of US children experienced a special health care need in 2001. Although 95% of CSHCN had some type of insurance coverage at the time of the interview, 32% were classified as underinsured. Underinsured CSHCN were disproportionately represented in low-income families and were significantly more likely than fully insured children to have unmet health needs, and their families were more likely to report difficulty in obtaining specialty referrals, experience financial problems, and report that the child's condition caused family members to reduce or stop work. Underinsured CSHCN seemed to be somewhat better off than CSHCN with no insurance coverage on these measures. CONCLUSIONS: Underinsured CSHCN represent an important and largely hidden underserved population.
SN - 0031-4005
AD - Maternal and Child Health Bureau Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857; mkogan@hrsa.gov
U2 - PMID: 16264004.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106373968&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Crosby, Richard A.
AU - DiClemente, Ralph J.
AU - Wingood, Gina M.
AU - Salazar, Laura F.
AU - Rose, Eve
AU - Levine, David
AU - Brown, Larry
AU - Lescano, Celia
AU - Pugatch, David
AU - Flanigan, Timothy
AU - Fernandez, Isa
AU - Schlenger, William
AU - Silver, Barabra J.
T1 - Correlates of condom failure among adolescent males: An exploratory study
JO - Preventive Medicine
JF - Preventive Medicine
Y1 - 2005/11//Nov/Dec2005
VL - 41
IS - 5/6
M3 - Article
SP - 873
EP - 876
SN - 00917435
AB - Abstract: Objective. : To identify the prevalence and correlates of condom failure (defined as breakage or slipping off in the past 90 days) among a sample of adolescent males (15 to 21 years of age). Design. : A cross-sectional study of 481 condom-using males residing in three US cities (Atlanta, GA, Providence RI, Miami FL). Data were collected, in the years 2000 and 2001, using audio computer-assisted self-interviewing technology. Prevalence ratios were used to determine the strength and significance of bivariate associations between ten assessed correlates and condom failure. Correlates achieving a screening level of significance were entered into a multivariate model that was used to calculate adjusted odds ratios (AOR). Results. : Recent condom failure was reported by 34.1%. Younger adolescents were about one-third less likely to report condom failure (AOR = 0.66; P = 0.4). Adolescents reporting multiple sex partners were about 80% more likely to report failure (AOR = 1.84; P = 0.09). Adolescents indicating they had sex with someone on the same day they met the person were about 80% more likely to report failure (AOR = 1.77; P = 0.02). Finally, adolescents indicating recent problems obtaining condoms were about 70% more likely to report failure (AOR = 1.69; P = 0.1). Failure was not less common among those reporting a history of STD infection or those ever impregnating a partner. Conclusion. : Because adolescent males may commonly experience condom failure, targeted clinic- and community-based programs designed to reduce user error could be an important aspect of preventing pregnancy and the spread of STDs. [Copyright &y& Elsevier]
AB - Copyright of Preventive Medicine is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS
KW - TEENAGE boys
KW - SEXUALLY transmitted diseases -- Prevention
KW - COMMUNICABLE diseases
KW - Adolescents
KW - Condoms
KW - Prevention
KW - Sexually transmitted diseases
N1 - Accession Number: 19167761; Crosby, Richard A. 1,2; Email Address: crosby@uky.edu DiClemente, Ralph J. 1,2,3,4 Wingood, Gina M. 1,2 Salazar, Laura F. 1,2 Rose, Eve 1 Levine, David 5 Brown, Larry 6 Lescano, Celia 6 Pugatch, David 7 Flanigan, Timothy 8 Fernandez, Isa 9 Schlenger, William 10 Silver, Barabra J. 11; Affiliation: 1: Department of Behavioral Sciences and Health Education, Rollins School of Public Health, GA 30322, USA 2: Emory Center for AIDS Research, GA 30322, USA 3: Department of Pediatrics, Emory University School of Medicine, GA 30322, USA 4: Department of Medicine, Emory University School of Medicine, GA 30322, USA 5: Department of Pediatrics, Morehouse School of Medicine, GA 30310-1495, USA 6: Department of Psychiatry, Brown University School of Medicine, RI 02912, USA 7: Department of Pediatrics, Brown University School of Medicine, RI 02912, USA 8: Department of Medicine, Brown University School of Medicine, RI 02912, USA 9: Department of Epidemiology and Public Health, University of Miami, FL 33149-1098, USA 10: Research Triangle Institute, NC 27709, USA 11: Center for Mental Health Services, SAMHSA, MD 20857, USA; Source Info: Nov/Dec2005, Vol. 41 Issue 5/6, p873; Subject Term: TEENAGERS; Subject Term: TEENAGE boys; Subject Term: SEXUALLY transmitted diseases -- Prevention; Subject Term: COMMUNICABLE diseases; Author-Supplied Keyword: Adolescents; Author-Supplied Keyword: Condoms; Author-Supplied Keyword: Prevention; Author-Supplied Keyword: Sexually transmitted diseases; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ypmed.2005.09.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simpson, Sherri
T1 - Dignosis: Rescue Fantasy, NOS.
JO - Psychiatric Times
JF - Psychiatric Times
Y1 - 2005/11//
VL - 22
IS - 13
M3 - Article
SP - 24
EP - 24
SN - 08932905
AB - The article discusses the involvement of the author in the Building Bridges outreach program in the U.S. developed by child and adolescent psychiatrist Dawnelle Schatte. Manifestations of rescuer fantasy disorder suffered by the author is enumerated. The team solicited the support of psychological associations in an effort to expose the African American community to different partners in mental health care. An estimated 90% of the members of the Shrine of the Black Madonna in Houston, Texas participated in the program.
KW - OUTREACH programs
KW - MENTAL health services
KW - AFRICAN Americans
KW - UNITED States
KW - SCHATTE, Dawnelle
N1 - Accession Number: 19176747; Simpson, Sherri 1,2,3; Affiliation: 1: Fellow, Baylor College of Medicine 2: Chair, APA/AstraZeneca Minority Fellowship 3: Substance Abuse and Mental Health Services Administration Minority Fellowship; Source Info: Nov2005, Vol. 22 Issue 13, p24; Subject Term: OUTREACH programs; Subject Term: MENTAL health services; Subject Term: AFRICAN Americans; Subject Term: UNITED States; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624110 Child and Youth Services; People: SCHATTE, Dawnelle; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Baron, Sherry L.
T1 - Injuries in Child Laborers in the Informal Sector in Mexico City, Mexico, 1997.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2005/11//Nov/Dec2005
VL - 120
IS - 6
M3 - Editorial
SP - 598
EP - 601
SN - 00333549
AB - Focuses on the prevalence of child labor in Mexico City, Mexico as of 1997. Information on the child labor laws in Mexico; Types of work-related injuries which child laborers experienced; Percentage of the child laborers who lived on the streets.
KW - CHILD labor
KW - LABOR laws & legislation
KW - WORK-related injuries
KW - MEXICO City (Mexico)
KW - MEXICO
N1 - Accession Number: 18927821; Baron, Sherry L. 1; Email Address: sbaron@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health; Source Info: Nov/Dec2005, Vol. 120 Issue 6, p598; Subject Term: CHILD labor; Subject Term: LABOR laws & legislation; Subject Term: WORK-related injuries; Subject Term: MEXICO City (Mexico); Subject Term: MEXICO; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106382821
T1 - Injuries in child laborers in the informal sector in Mexico City, Mexico, 1997.
AU - Baron SL
Y1 - 2005/11//Nov/Dec2005
N1 - Accession Number: 106382821. Language: English. Entry Date: 20060120. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Child Health
KW - Disease Surveillance
KW - Occupational-Related Injuries -- Epidemiology -- Mexico
KW - Occupational-Related Injuries -- In Infancy and Childhood -- Mexico
KW - Work -- In Infancy and Childhood
KW - Administrative Personnel
KW - Adolescence
KW - Child
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - Fractures
KW - Hospitals, Public
KW - Interviews
KW - Male
KW - Mexico
KW - Pan American Health Organization
KW - Pilot Studies
KW - Private Sector
KW - Public Housing -- In Infancy and Childhood
KW - Questionnaires
KW - Sex Factors
KW - Sprains and Strains
KW - Surveys
KW - Time
KW - Trauma
KW - Work -- Legislation and Jurisprudence -- Mexico
KW - Wounds and Injuries -- Epidemiology -- In Infancy and Childhood
KW - Human
SP - 598
EP - 601
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 120
IS - 6
PB - Sage Publications Inc.
SN - 0033-3549
AD - Coordinator, Priority Populations and Health Disparities, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R13, Cincinnati, OH 45226; sbaron@cdc.gov
U2 - PMID: 16350328.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carman, Robert J.
AU - Simon, Mary Alice
AU - Petzold, H. Earl
AU - Wimmer, Robert F.
AU - Batra, Monica R.
AU - Fernández, A. Haydée
AU - Miller, Margaret A.
AU - Bartholomew, Mary
T1 - Antibiotics in the human food chain: Establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/11//
VL - 43
IS - 2
M3 - Article
SP - 168
EP - 180
SN - 02732300
AB - Abstract: A chemostat model of the healthy human large bowel ecosystem was used to establish no effect levels for tetracycline, neomycin, and erythromycin. For each compound, the equivalent to four oral doses (0, 1.5, 15, and 150mg/60kg person/d) was studied. Concentrations of the test compounds in the chemostat medium were intended to simulate fecal levels that might be expected following consumption of food containing antibiotic residue and were based on published oral doses and fecal levels. We monitored the following parameters: short chain fatty acids, bile acids, sulfate reduction, azoreductase and nitroreductase activities, β-glucosidase and β-glucuronidase activities, a range of bacterial counts and, lastly, the susceptibility among sentinel bacteria to each test compound. Neomycin and erythromycin reduced bile acid metabolism. Neomycin elevated propionate levels and caused a marginal diminution in azoreductase activity. Based on our results, the no observed effect level (NOEL) of both tetracycline and erythromycin was 15mg/60kg person/d. The NOEL for neomycin was 1.5mg/60kg person/d. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibiotics
KW - Anti-infective agents
KW - Antibiotic residues
KW - Erythromycin
KW - Acceptable daily intake
KW - ADI
KW - Chemostat
KW - Human
KW - Intestinal
KW - Low level
KW - Microflora
KW - Neomycin
KW - NOEL
KW - Residue
KW - Tetracycline
KW - Trace
N1 - Accession Number: 18779031; Carman, Robert J. 1; Email Address: rjcarman@techlab.com; Simon, Mary Alice 1; Petzold, H. Earl 1; Wimmer, Robert F. 1; Batra, Monica R. 1; Fernández, A. Haydée 2; Miller, Margaret A. 2; Bartholomew, Mary 2; Affiliations: 1: TechLab, Inc., 2001 Kraft Drive, Blacksburg, VA 24060-6358, USA; 2: United States Food and Drug Administration-Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Nov2005, Vol. 43 Issue 2, p168; Thesaurus Term: Antibiotics; Thesaurus Term: Anti-infective agents; Thesaurus Term: Antibiotic residues; Subject Term: Erythromycin; Author-Supplied Keyword: Acceptable daily intake; Author-Supplied Keyword: ADI; Author-Supplied Keyword: Chemostat; Author-Supplied Keyword: Human; Author-Supplied Keyword: Intestinal; Author-Supplied Keyword: Low level; Author-Supplied Keyword: Microflora; Author-Supplied Keyword: Neomycin; Author-Supplied Keyword: NOEL; Author-Supplied Keyword: Residue; Author-Supplied Keyword: Tetracycline; Author-Supplied Keyword: Trace; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.06.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murono, Eisuke P.
AU - Derk, Raymond C.
T1 - The reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits testosterone formation by cultured Leydig cells from neonatal rats
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2005/11//
VL - 20
IS - 4
M3 - Article
SP - 503
EP - 513
SN - 08906238
AB - Abstract: Methoxychlor (MC) is an insecticide that is presently used on agricultural crops, especially after the ban on the use of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) in the United States. Following administration in vivo, MC is converted to 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which is thought to be the active agent. However, both MC and HPTE have been reported to have weak estrogenic and antiandrogenic activities, and they are thought to exert their potential adverse (endocrine disruptive) effects through the estrogen and androgen receptors, respectively. In a recent study, HPTE was shown to inhibit both basal and hCG-stimulated testosterone production by cultured Leydig cells from immature and adult rats, and these effects were reported to be mediated through the estrogen receptor. Because fetal Leydig cells represent a separate population from adult Leydig cells and many of the reported adverse actions of endocrine disruptors are thought to have their effects during gestational exposure, the present studies examined the effects of HPTE on testosterone formation by cultured fetal Leydig cells from neonatal rats to determine whether these cells are sensitive to HPTE. Our studies demonstrated that HPTE inhibited both basal and hCG-stimulated testosterone formation in a dose-dependent manner. Significant declines in testosterone were observed at about 100nM HPTE, and this effect was detected as early as 1h after exposure. The main effects of HPTE appeared to be localized to the cholesterol side-chain cleavage step which converts cholesterol to pregnenolone. In addition, this effect did not appear to be mediated through the estrogen receptor as a weak estrogen or the androgen receptor as an antiandrogen, which are the currently proposed modes of action of MC and HPTE. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHANES
KW - ESTROGEN
KW - ANDROGENS
KW - ISOPENTENOIDS
KW - HPTE
KW - Neonatal Leydig cell
KW - Testosterone
N1 - Accession Number: 18628306; Murono, Eisuke P.; Email Address: eisuke.murono@cdc.hhs.gov Derk, Raymond C. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA; Source Info: Nov2005, Vol. 20 Issue 4, p503; Subject Term: ETHANES; Subject Term: ESTROGEN; Subject Term: ANDROGENS; Subject Term: ISOPENTENOIDS; Author-Supplied Keyword: HPTE; Author-Supplied Keyword: Neonatal Leydig cell; Author-Supplied Keyword: Testosterone; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.reprotox.2005.03.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sammarco, John J.
T1 - Operationalizing normal accident theory for safety-related computer systems
JO - Safety Science
JF - Safety Science
Y1 - 2005/11//
VL - 43
IS - 9
M3 - Article
SP - 697
EP - 714
SN - 09257535
AB - Abstract: Computer-related accidents have caused injuries and fatalities in mining as well as other industries. Normal accident theory (NAT) explains that some accidents are inevitable because of system complexity. NAT is a classic argument in organizational sociology although it has been criticized as having imprecise definitions and lacking criteria for quantifying complexity. These limitations are addressed by a unique approach that recasts this organizational theory into an engineering-based methodology to quantify NAT complexities of computer-based systems. In this approach complexity is categorized as external or internal. External complexity is defined by the external behavior of a system, and is quantified by these dependent variables: system predictability, observability, and usability. Dependent variable data contain the perceptions of 32 subjects running simulations of a system. The system’s internal complexity is characterized by modeling system-level requirements with the software cost reduction (SCR) formal method. Model attributes are quantified using 15 graph-theoretical metrics—the independent variables. Five of 15 metrics are correlated with the dependent variables as evidenced by structure correlations exceeding 0.25, with standard errors <0.10 and a 95% confidence interval. The results also show that the system predictability, observability, and usability decreased as NAT complexities increased. This research takes a step forward in operationalizing NAT for computerized systems. The research benefits mining and other industries as well. [Copyright &y& Elsevier]
AB - Copyright of Safety Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Computer systems
KW - Industrial safety
KW - Computer industry
KW - Accident prevention
KW - Normal accident theory
KW - System complexity
KW - System safety
N1 - Accession Number: 19010796; Sammarco, John J. 1; Email Address: JSammarco@cdc.gov; Affiliations: 1: Pittsburgh Research Laboratory, Mining Injury Prevention Branch, National Institute for Occupational Safety and Health, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Nov2005, Vol. 43 Issue 9, p697; Thesaurus Term: Computer systems; Thesaurus Term: Industrial safety; Subject Term: Computer industry; Subject Term: Accident prevention; Author-Supplied Keyword: Normal accident theory; Author-Supplied Keyword: System complexity; Author-Supplied Keyword: System safety; NAICS/Industry Codes: 334111 Electronic Computer Manufacturing; NAICS/Industry Codes: 443142 Electronics Stores; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 334110 Computer and peripheral equipment manufacturing; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.ssci.2005.03.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jacobs, Abigail
T1 - Prediction of 2-Year Carcinogenicity Study Results for Pharmaceutical Products: How Are We Doing?
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 18
EP - 23
PB - Oxford University Press / USA
SN - 10966080
AB - Some have proposed that 2-year carcinogenicity studies may not be necessary if the material is a direct-acting DNA mutagen, induces liver enzymes, causes hyperplasia or toxicity in particular organs, causes cell proliferation, is cytotoxic, causes hormonal perturbations, or if one has QSAR analyses or ‘omics information. Safety pharmacology data, pharmacologic activity, metabolism data, and results of 13-week dose ranging studies (with organ weight data, clinical chemistry data, hematologic data, clinical signs and histopathologic findings) were compared with results of 2-year carcinogenicity studies reviewed by the Center for Drug Evaluation and Research (CDER)/FDA. The experience with the ICH genetic toxicology battery and alternative carcinogenicity models was also reviewed. It appears that the information available from short-term studies is not currently sufficient to accurately and reliably predict the outcome of long-term carcinogenicity studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Structure-activity relationships (Biochemistry)
KW - QSAR (Biochemistry)
KW - Carcinogenicity testing
KW - DNA
KW - Pharmaceutical research
KW - Cell proliferation
KW - Mutation (Biology)
KW - carcinogenicity
KW - drug
KW - genetic toxicology
N1 - Accession Number: 20605770; Jacobs, Abigail 1; Email Address: Abigail.Jacobs@fda.hhs.gov; Affiliations: 1: Center for Drug Evaluation and Research, USFDA, 9201 Corporate Blvd, Rm N212, Rockville, Maryland 20850; Issue Info: Nov2005, Vol. 88 Issue 1, p18; Thesaurus Term: RESEARCH; Thesaurus Term: Structure-activity relationships (Biochemistry); Thesaurus Term: QSAR (Biochemistry); Subject Term: Carcinogenicity testing; Subject Term: DNA; Subject Term: Pharmaceutical research; Subject Term: Cell proliferation; Subject Term: Mutation (Biology); Author-Supplied Keyword: carcinogenicity; Author-Supplied Keyword: drug; Author-Supplied Keyword: genetic toxicology; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1093/toxsci/kfi248
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ladics, Gregory S.
AU - Chapin, Robert E.
AU - Hastings, Kenneth L.
AU - Holsapple, Michael P.
AU - Makris, Susan L.
AU - Sheets, Larry P.
AU - Woolhiser, Michael R.
AU - Burns-Naas, Leigh Ann
T1 - Developmental Toxicology Evaluations—Issues with Including Neurotoxicology and Immunotoxicology Assessments in Reproductive Toxicology Studies.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 24
EP - 29
PB - Oxford University Press / USA
SN - 10966080
AB - Developmental and reproductive toxicology (DART) has routinely been a part of safety assessment. Attention is now focused on the effects of chemicals on the developing nervous and immune systems. This focus on developmental neurotoxicology (DNT) and developmental immunotoxicology (DIT) is based on the premise that children differ from adults in some aspects of their biology and, thus, may also differ in their responses to chemicals. This session's objective was to discuss issues common to DNT and DIT as they relate to DART protocols, including high dose selection and maternal toxicity, adequacy of pup exposure during lactation, use of a different dosing paradigm for DART versus DNT or DIT studies, and whether DIT and DNT endpoints can be incorporated into a single DART study for hazard identification purposes. Consensus was achieved on all topics except the adequacy for risk assessment purposes of the use of a limited number of endpoints for DIT and DNT, with the DNT endpoints being the primary focus of disagreement. Panelists indicated that a combination study design for hazard identification was feasible, though flexibility to meet the scientific needs of the project was emphasized. The adequacy of existing triggers for additional developmental studies was also questioned. Panelists iterated the importance of understanding pup exposure during the various life stages and the use of toxicokinetic data in designing these studies. The group agreed to consider the HESI ACSA Life Stages Task Force recommendations as a next step to address some of the issues and challenges raised during this session. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemicals -- Safety measures
KW - Developmental biology
KW - Reproductive toxicology
KW - Immunologic diseases
KW - Neurotoxicology
KW - Immunotoxicology
KW - combination study
KW - DART
KW - developmental and reproductive toxicology
KW - developmental immunotoxicology
KW - developmental neurotoxicology
KW - DIT
KW - DNT
KW - hazard identification
KW - panel discussion
KW - study design
N1 - Accession Number: 20605793; Ladics, Gregory S. 1; Email Address: gregory.s.ladics@usa.dupont.com; Chapin, Robert E. 2; Hastings, Kenneth L. 3; Holsapple, Michael P. 4; Makris, Susan L. 5; Sheets, Larry P. 6; Woolhiser, Michael R. 7; Burns-Naas, Leigh Ann 8; Email Address: leighann.burns@pfizer.com; Affiliations: 1: DuPont Company., Haskell Laboratory, Newark, Delaware 19714; 2: Worldwide Safety Sciences, Pfizer Global Research and Development, Groton, Connecticut 06340; 3: United States Food and Drug Administration, Center for Drug Evaluation Research, Office of New Drugs, Rockville, Maryland 20857; 4: ILSI Health and Environmental Sciences Institute, Washington, DC 200055802; 5: United States Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460-0001; 6: Bayer CropScience LP, Stilwell, Kansas 66085-9104; 7: Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, Michigan 48674; 8: Worldwide Safety Sciences, Pfizer Global Research and Development, San Diego, CA 92064; Issue Info: Nov2005, Vol. 88 Issue 1, p24; Thesaurus Term: Chemicals -- Safety measures; Thesaurus Term: Developmental biology; Subject Term: Reproductive toxicology; Subject Term: Immunologic diseases; Subject Term: Neurotoxicology; Subject Term: Immunotoxicology; Author-Supplied Keyword: combination study; Author-Supplied Keyword: DART; Author-Supplied Keyword: developmental and reproductive toxicology; Author-Supplied Keyword: developmental immunotoxicology; Author-Supplied Keyword: developmental neurotoxicology; Author-Supplied Keyword: DIT; Author-Supplied Keyword: DNT; Author-Supplied Keyword: hazard identification; Author-Supplied Keyword: panel discussion; Author-Supplied Keyword: study design; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1093/toxsci/kfi299
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ER -
TY - JOUR
AU - Yin, Xuejun J.
AU - Dong, Caroline C.
AU - Ma, Jane Y. C.
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Barger, Mark W.
AU - Ma, Joseph K. H.
T1 - Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte–Mediated Immune Responses Against Listeria monocytogenes .
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 73
EP - 81
PB - Oxford University Press / USA
SN - 10966080
AB - Studies have shown that exposure to diesel exhaust particles (DEP) suppresses pulmonary host defense against bacterial infection. The present study was carried out to characterize whether DEP exposure exerts a sustained effect in which inhaled DEP increase the susceptibility of the lung to bacterial infection occurring at a later time. Brown Norway rats were exposed to filtered air or DEP by inhalation at a dose of 21.2 ± 2.3 mg/m3, 4 h/day for 5 days, and intratracheally instilled with saline or 100,000 Listeria monocytogenes (Listeria) 7 days after the final DEP exposure. Bacterial growth and cellular responses to DEP and Listeria exposures were examined at 3 and 7 days post-infection. The results showed that inhaled DEP prolonged the growth of bacteria, administered 7 days post DEP exposure, in the lung as compared to the air-exposed controls. Pulmonary responses to Listeria infection were characterized by increased production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-12, and IL-10 by alveolar macrophages (AM) and increased presence of T lymphocytes and their CD4+ and CD8+ subsets in lung draining lymph nodes that secreted elevated levels of IL-2, IL-6, IL-10, and interferon (IFN)-γ. Diesel exhaust particles were found to inhibit Listeria-induced production of IL-1β and TNF-α, which are responsible for the innate immunity, and IL-12, which initiates the development of T helper (Th)1 responses, but enhance Listeria-induced AM production of IL-10, which prolongs Listeria survival in these phagocytes. The dual action of DEP on AM production of IL-12 and IL-10 correlated with an inhibition of the development of bacteria-specific T lymphocytes by DEP. Cytokine production by lymphocytes from DEP- and Listeria-exposed rats showed a marked decrease in the production of IL-2, IL-10, and IFN-γ compared to Listeria infection alone, suggesting either that DEP inhibit the production of cytokines by lymphocytes or that these lymphocytes contained T-cell subsets that are different from those of Listeria infection alone and less effective in mediating Th1 immune responses. This study demonstrates that inhaled DEP, after a 7-day resting period, increase the susceptibility of the lung to bacterial infection occurring at a later time by inhibiting macrophage immune function and suppressing the development of T-cell–mediated immune responses. The results support the epidemiological observations that exposure to DEP may be responsible for the pulmonary health effects on humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diethyl phthalate
KW - RESEARCH
KW - Lung diseases
KW - Bacterial diseases
KW - Diesel motor exhaust gas
KW - Combustion gases
KW - Bacterial growth
KW - Macrophages
KW - alveolar macrophages
KW - diesel exhaust particles
KW - host defense
KW - Listeria monocytogenes
KW - T lymphocytes
N1 - Accession Number: 20605777; Yin, Xuejun J. 1; Dong, Caroline C. 1; Ma, Jane Y. C. 2; Antonini, James M. 2; Roberts, Jenny R. 2; Barger, Mark W. 2; Ma, Joseph K. H. 1; Email Address: jma@hsc.wvu.edu; Affiliations: 1: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Nov2005, Vol. 88 Issue 1, p73; Thesaurus Term: Diethyl phthalate; Thesaurus Term: RESEARCH; Subject Term: Lung diseases; Subject Term: Bacterial diseases; Subject Term: Diesel motor exhaust gas; Subject Term: Combustion gases; Subject Term: Bacterial growth; Subject Term: Macrophages; Author-Supplied Keyword: alveolar macrophages; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: host defense; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: T lymphocytes; Number of Pages: 9p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi279
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nan Mei
AU - Qingsu Xia
AU - Ling Chen
AU - Moore, Martha M.
AU - Fu, Peter P.
AU - Tao Chen
T1 - Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 142
EP - 149
PB - Oxford University Press / USA
SN - 10966080
AB - Retinyl palmitate (RP), a storage form of vitamin A, is frequently used as a cosmetic ingredient, with more than 700 RP-containing cosmetic products on the U.S. market in 2004. There are concerns for the possible genotoxicity and carcinogenicity of RP when it is exposed to sunlight. To evaluate the photomutagenicity of RP in cells when exposed to ultraviolet A (UVA) light, L5178Y/Tk+/− mouse lymphoma cells were treated with different doses of RP alone/or in the presence of UVA light. Treatment of the cells with RP alone at the dose range of 25–100 μg/ml did not increase mutant frequencies (MFs) over the negative control, whereas treatment of cells with 1–25 μg/ml RP under UVA light (82.8 mJ/cm2/min for 30 min) produced a dose-dependent mutation induction. The mean induced MF (392 × 10−6) for treatment with 25 μg/ml RP under UVA exposure was about threefold higher than that for UVA alone (122 × 10−6), a synergistic effect. To elucidate the underlying mechanism of action, we examined the mutants for loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11, on which the Tk gene is located. The mutational spectrum for the RP + UVA treatment was significantly different from the negative control, but not significantly different from UVA exposure alone. Ninety four percent of the mutants from RP + UVA treatment lost the Tk+ allele, and 91% of the deleted sequences extended more than 6 cM in chromosome length, indicating clastogenic events affecting a large segment of the chromosome. These results suggest that RP is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Vitamin A
KW - Fat-soluble vitamins
KW - Carcinogenicity testing
KW - Retinoids
KW - Cell nuclei
KW - United States
KW - loss of heterozygosity
KW - mouse lymphoma assay
KW - mutant frequency
KW - photomutagenicity
KW - retinyl palmitate
KW - UVA
N1 - Accession Number: 20605788; Nan Mei 1; Qingsu Xia 2; Ling Chen 1,3; Moore, Martha M. 1; Fu, Peter P. 2; Email Address: pfu@nctr.fda.gov; Tao Chen 1; Email Address: tchen@nctr.fda.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079; 3: College of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China; Issue Info: Nov2005, Vol. 88 Issue 1, p142; Thesaurus Term: RESEARCH; Subject Term: Vitamin A; Subject Term: Fat-soluble vitamins; Subject Term: Carcinogenicity testing; Subject Term: Retinoids; Subject Term: Cell nuclei; Subject: United States; Author-Supplied Keyword: loss of heterozygosity; Author-Supplied Keyword: mouse lymphoma assay; Author-Supplied Keyword: mutant frequency; Author-Supplied Keyword: photomutagenicity; Author-Supplied Keyword: retinyl palmitate; Author-Supplied Keyword: UVA; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi291
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ER -
TY - JOUR
AU - Dong, Caroline C.
AU - Yin, Xuejun J.
AU - Ma, Jane Y. C.
AU - Millecchia, Lyndell
AU - Barger, Mark W.
AU - Roberts, Jenny R.
AU - Xing-Dong Zhang
AU - Antonini, James M.
AU - Ma, Joseph K. H.
T1 - Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin (OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuates OVA-Induced Airway Inflammation.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 150
EP - 160
PB - Oxford University Press / USA
SN - 10966080
AB - Exposure to diesel exhaust particles (DEP) during the sensitization process has been shown to increase antigen-specific IgE production and aggravate allergic airway inflammation in human and animal models. In this study, we evaluated the effect of short-term DEP exposure on ovalbumin (OVA)-mediated responses using a post-sensitization model. Brown Norway rats were first exposed to filtered air or DEP (20.6 ± 2.7 mg/m3) for 4 h/day for five consecutive days. One day after the final air or DEP exposure (day 1), rats were sensitized with aerosolized OVA (40.5 ± 6.3 mg/m3), and then again on days 8 and 15, challenged with OVA on day 29, and sacrificed on days 9 or 30, 24 h after the second OVA exposure or the final OVA challenge, respectively. Control animals received aerosolized saline instead of OVA. DEP were shown to elicit an adjuvant effect on the production of antigen-specific IgE and IgG on day 30. At both time points, no significant airway inflammatory responses and lung injury were found for DEP exposure alone. However, the OVA-induced inflammatory cell infiltration, acellular lactate dehydrogenase activity and albumin content in bronchoalveolar lavage (BAL) fluid, and numbers of T cells and their CD4+ and CD8+ subsets in lung-draining lymph nodes were markedly reduced by DEP on day 30 compared with the air-plus-OVA exposure group. The OVA-induced nitric oxide (NO) in the BAL fluid and production of NO, interleukin (IL)-10, and IL-12 by alveolar macrophages (AM) were also significantly lowered by DEP on day 30 as well as day 9. DEP or OVA alone decreased intracellular glutathione (GSH) in AM and lymphocytes on days 9 and 30. The combined DEP and OVA exposure resulted in further depletion of GSH in both cell types. These results show that short-term DEP exposure prior to sensitization had a delayed effect on enhancement of the sensitization in terms of allergen-specific IgE and IgG production, but caused an attenuation of the allergen-induced airway inflammatory responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel motor exhaust gas
KW - Antigens
KW - Allergy
KW - DISEASES
KW - Immunoglobulin E
KW - Lung diseases
KW - Lymph nodes
KW - Immunoglobulin G
KW - adjuvant effect
KW - airway inflammation
KW - cytokines
KW - diesel exhaust particles
KW - glutathione
KW - nitrite oxide
N1 - Accession Number: 20605792; Dong, Caroline C. 1; Yin, Xuejun J. 1; Ma, Jane Y. C. 2; Millecchia, Lyndell 2; Barger, Mark W. 2; Roberts, Jenny R. 2; Xing-Dong Zhang 2; Antonini, James M. 2; Ma, Joseph K. H. 1; Email Address: jma@hsc.wvu.edu; Affiliations: 1: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Nov2005, Vol. 88 Issue 1, p150; Thesaurus Term: Diesel motor exhaust gas; Thesaurus Term: Antigens; Thesaurus Term: Allergy; Thesaurus Term: DISEASES; Subject Term: Immunoglobulin E; Subject Term: Lung diseases; Subject Term: Lymph nodes; Subject Term: Immunoglobulin G; Author-Supplied Keyword: adjuvant effect; Author-Supplied Keyword: airway inflammation; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: glutathione; Author-Supplied Keyword: nitrite oxide; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi298
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dong, Caroline C.
AU - Yin, Xuejun J.
AU - Ma, Jane Y. C.
AU - Millecchia, Lyndell
AU - Zhong-Xin Wu
AU - Barger, Mark W.
AU - Roberts, Jenny R.
AU - Antonini, James M.
AU - Dey, Richard D.
AU - Ma, Joseph K. H.
T1 - Effect of Diesel Exhaust Particles on Allergic Reactions and Airway Responsiveness in Ovalbumin-Sensitized Brown Norway Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2005/11//
VL - 88
IS - 1
M3 - Article
SP - 202
EP - 212
PB - Oxford University Press / USA
SN - 10966080
AB - We have previously demonstrated that exposure to diesel exhaust particles (DEP) prior to ovalbumin (OVA) sensitization in rats reduced OVA-induced airway inflammation. In the present study, Brown Norway rats were first sensitized to OVA (42.3 ± 5.7 mg/m3) for 30 min on days 1, 8, and 15, then exposed to filtered air or DEP (22.7 ± 2.5 mg/m3) for 4 h/day on days 24–28, and challenged with OVA on day 29. Airway responsiveness was examined on day 30, and animals were sacrificed on day 31. Ovalbumin sensitization and challenge resulted in a significant infiltration of neutrophils, lymphocytes, and eosinophils into the lung, elevated presence of CD4+ and CD8+ T lymphocytes in lung draining lymph nodes, and increased production of serum OVA-specific immunoglobulin (Ig)E and IgG. Diesel exhaust particles pre-exposure augmented OVA-induced production of allergen-specific IgE and IgG and pulmonary inflammation characterized by marked increases in T lymphocytes and infiltration of eosinophils after OVA challenge, whereas DEP alone did not have these effects. Although OVA-sensitized rats showed modest response to methacholine challenge, it was the combined DEP and OVA exposure that produced significant airway hyperresponsiveness in this animal model. The effect of DEP pre-exposure on OVA-induced immune responses correlated with an interactive effect of DEP with OVA on increased production of reactive oxygen species (ROS) and nitric oxide (NO) by alveolar macrophages (AM) and alveolar type II (ATII) cells, NO levels in bronchoalveolar lavage fluid, the induction of inducible NO synthase expression in AM and ATII cells, and a depletion of total intracellular glutathione (GSH) in AM and lymphocytes. These results show that DEP pre-exposure exacerbates the allergic responses to the subsequent challenge with OVA in OVA-sensitized rats. This DEP effect may be, at least partially, attributed to the elevated generation of ROS in AM and ATII cells, a depletion of GSH in AM and lymphocytes, and an increase in AM and ATII cell production of NO. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diethyl phthalate
KW - RESEARCH
KW - DISEASES
KW - Albumins
KW - Lymph nodes
KW - Rats
KW - T cells
KW - Macrophages
KW - airway hyperresponsiveness
KW - airway inflammation
KW - diesel exhaust particles
KW - glutathione
KW - nitric oxide
KW - reactive oxygen species
N1 - Accession Number: 20605778; Dong, Caroline C. 1; Yin, Xuejun J. 1; Ma, Jane Y. C. 2; Millecchia, Lyndell 2; Zhong-Xin Wu 3; Barger, Mark W. 2; Roberts, Jenny R. 2; Antonini, James M. 2; Dey, Richard D. 3; Ma, Joseph K. H. 1; Email Address: jma@hsc.wvu.edu; Affiliations: 1: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; 3: School of Medicine, West Virginia University, Morgantown, West Virginia 26506; Issue Info: Nov2005, Vol. 88 Issue 1, p202; Thesaurus Term: Diethyl phthalate; Thesaurus Term: RESEARCH; Thesaurus Term: DISEASES; Subject Term: Albumins; Subject Term: Lymph nodes; Subject Term: Rats; Subject Term: T cells; Subject Term: Macrophages; Author-Supplied Keyword: airway hyperresponsiveness; Author-Supplied Keyword: airway inflammation; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: glutathione; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: reactive oxygen species; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 9 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfi280
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Doerge, Daniel R.
AU - Young, John F.
AU - McDaniel, L. Patrice
AU - Twaddle, Nathan C.
AU - Churchwell, Mona I.
T1 - Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2005/11//
VL - 208
IS - 3
M3 - Article
SP - 199
EP - 209
SN - 0041008X
AB - Abstract: Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms, particularly toxicokinetics and bioavailability. This study compares the toxicokinetics of AA and its epoxide metabolite, glycidamide (GA), in serum and tissues of male and female F344 rats following acute exposure by intravenous, gavage, and dietary routes at 0.1 mg/kg AA or intravenous and gavage routes with an equimolar amount of GA. AA was rapidly absorbed after oral dosing, was widely distributed to tissues, was efficiently converted to GA, and produced increased levels of GA-DNA adducts in liver. GA was also rapidly absorbed, widely distributed to tissues, and produced increased liver DNA adduct levels. AA bioavailability after aqueous gavage was 60–98% and from the diet was 32–44%; however, first-pass metabolism or other kinetic change resulted in much higher internal exposures to GA (2- to 7-fold) when compared to the intravenous route. A similar effect on metabolism to GA following oral administration was previously observed under an identical exposure paradigm in mice. Furthermore, DNA adduct formation in rat liver showed the same proportionality with the respective GA AUC value as did mice in the previous study. These findings suggest that as the AA content in food is reduced, species-differences in GA formation and subsequent DNA adduct formation may be minimized. These findings provide additional information needed to assess genotoxic risks from the low levels of AA that are pervasive in the food supply. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acrylamide
KW - Germ cells
KW - Toxicology
KW - Organs (Anatomy)
KW - Fischer 344 rats
KW - Glycidamide
N1 - Accession Number: 18953447; Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov; Young, John F. 1; McDaniel, L. Patrice 1; Twaddle, Nathan C. 1; Churchwell, Mona I. 1; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Nov2005, Vol. 208 Issue 3, p199; Thesaurus Term: Acrylamide; Thesaurus Term: Germ cells; Thesaurus Term: Toxicology; Subject Term: Organs (Anatomy); Author-Supplied Keyword: Fischer 344 rats; Author-Supplied Keyword: Glycidamide; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2005.03.003
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ER -
TY - JOUR
AU - Bányai, Krisztián
AU - Forgách, Petra
AU - Erdélyi, Károly
AU - Martella, Vito
AU - Bogdán, Ágnes
AU - Hocsák, Enikő
AU - Havasi, Viktória
AU - Melegh, Béla
AU - Szűcs, György
T1 - Identification of the novel lapine rotavirus genotype P[22] from an outbreak of enteritis in a Hungarian rabbitry
JO - Virus Research
JF - Virus Research
Y1 - 2005/11//
VL - 113
IS - 2
M3 - Article
SP - 73
EP - 80
SN - 01681702
AB - Abstract: Application of improved molecular techniques in the detection and characterization of rotavirus strains has led to the recent description of several new combinations, specificities, and genetic variants of the outer capsid genes, VP7 and VP4. In spite of the enormous diversity of mammalian rotavirus strains, the few lapine rotaviruses characterized to date, appear to carry a narrow range of such antigen combinations; only P[14], G3 and, based on a more recent study, P[22], G3 rotaviruses have proved to be epidemiologically important in rabbits. In the present study, we characterized a lapine group A rotavirus with a super-short electropherotype detected in an outbreak of fatal enteritis in a Hungarian commercial rabbitry. Based on sequence and phylogenetic analysis of the VP7, VP4, and NSP4 genes, our lapine strain is a P[22], G3 rotavirus that carries the NSP4 genotype shared by most lapine rotaviruses. Although the P[22] VP4 specificity has been newly identified, the relatively high sequence variation between our strain and those identified in Italy (89.1–90.4% nucleotide identity; region VP8*) implies that these strains diversified far before they were described for the first time, strongly suggesting that this genotype may have circulated in rabbitries or in nature without prior detection. We conclude that genotype P[22] lapine rotaviruses show a wider geographical dispersal than previously thought, although understanding their true epidemiological significance needs further investigation. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - GENETIC research
KW - INTESTINAL diseases
KW - GENES
KW - Diarrhea
KW - Molecular characterization
KW - Phylogenetic analysis
KW - Sequencing
N1 - Accession Number: 18341646; Bányai, Krisztián 1; Email Address: bkrota@hotmail.com Forgách, Petra 2 Erdélyi, Károly 3 Martella, Vito 4 Bogdán, Ágnes 1 Hocsák, Enikő 1 Havasi, Viktória 5 Melegh, Béla 5 Szűcs, György 1,6; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary 2: Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, István u. 2, H-1078 Budapest, Hungary 3: Department of Wildlife Diseases and Parasitology, Central Veterinary Institute, Tábornok u. 2, H-1149 Budapest, Hungary 4: Department of Animal Health and Well-Being, University of Bari, Sp Casamassima Km 3, 70010 Valenzano, Bari, Italy 5: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary 6: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary; Source Info: Nov2005, Vol. 113 Issue 2, p73; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC research; Subject Term: INTESTINAL diseases; Subject Term: GENES; Author-Supplied Keyword: Diarrhea; Author-Supplied Keyword: Molecular characterization; Author-Supplied Keyword: Phylogenetic analysis; Author-Supplied Keyword: Sequencing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.virusres.2005.03.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18341646&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2005-13302-003
AN - 2005-13302-003
AU - Feetham, Suzanne L.
T1 - Family Nursing: Challenges and Opportunities: Providing Leadership in Family Nursing From Local to Global Health.
JF - Journal of Family Nursing
JO - Journal of Family Nursing
JA - J Fam Nurs
Y1 - 2005/11//
VL - 11
IS - 4
SP - 327
EP - 331
CY - US
PB - Sage Publications
SN - 1074-8407
SN - 1552-549X
N1 - Accession Number: 2005-13302-003. PMID: 16287830 Partial author list: First Author & Affiliation: Feetham, Suzanne L.; Center for Quality, Health Resources and Services Administration, U.S. Department of Health and Human Services, US. Release Date: 20051024. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Family; Leadership; Nursing; Health Care Policy; Quality of Services. Minor Descriptor: Health; Health Care Services; Public Health; Global Health. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Nov, 2005.
AB - This is a time of opportunities for family nursing to make a difference in the health and well-being of families. This article frames family nursing through the lens of leadership for global health. With the current environment of rapid change in health care from technology and research, and global communication in milliseconds, it is important that family nurses apply the lens of policy, change, and leadership when working with individuals, families, and communities. A major premise of this article is that nurses should step forward as leaders to improve the health and well-being of individuals and their families and ultimately improve the health of our communities and our countries (Feetham, 1999, 2001; Feetham & Meister, 1999; Thorne, 1997). Assuming a policy and leadership lens for family nursing is essential for meeting the expectations of individuals and families for quality health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family nursing
KW - leadership
KW - global health
KW - policy
KW - change
KW - quality health care
KW - 2005
KW - Family
KW - Leadership
KW - Nursing
KW - Health Care Policy
KW - Quality of Services
KW - Health
KW - Health Care Services
KW - Public Health
KW - Global Health
KW - 2005
DO - 10.1177/1074840705280820
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13302-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-13656-008
AN - 2005-13656-008
AU - Wang, Min Qi
AU - Matthew, Resa F.
AU - Bellamy, Nikki
AU - James, Syretta
T1 - A structural model of the substance use pathways among minority youth.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2005/11//Nov-Dec, 2005
VL - 29
IS - 6
SP - 531
EP - 541
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Wang, Min Qi, Department of Public and Community Health, University of Maryland, College Park, MD, US, 20742
N1 - Accession Number: 2005-13656-008. PMID: 16336108 Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Wang, Min Qi; Department of Public and Community Health, University of Maryland, College Park, MD, US. Release Date: 20060117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Drug Abuse; Family; Minority Groups. Minor Descriptor: Involvement; Self-Control; Social Support. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Dunst Family Support Scale; CSAP National Youth Survey; Social Skills Rating Scale-Student Form. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov-Dec, 2005.
AB - Objective: To evaluate the substance use pathways of minority adolescents with a structural equation modeling (SEM) based on the social ecological model. Method: Seven hundred ninety adolescents completed the baseline survey questionnaire for the Center for Substance Abuse Prevention's Mentoring and Family Strengthening Initiative. The exogenous variables were family supervision, family involvement, and social support, whereas self-control, school connectedness, and substance use served as the endogenous variables. Results: The following significant direct effects were found: family involvement to self-control; self-control and social support to school connectedness; school connectedness to substance use. Conclusions: These findings provide empirical evidence that family protective factors can significantly influence adolescents' substance use and should be adopted into substance use prevention interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - school connectedness
KW - family involvement
KW - social support
KW - minority youth
KW - substance use
KW - self control
KW - family supervision
KW - 2005
KW - Adolescent Development
KW - Drug Abuse
KW - Family
KW - Minority Groups
KW - Involvement
KW - Self-Control
KW - Social Support
KW - 2005
DO - 10.5993/AJHB.29.6.8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-13656-008&site=ehost-live&scope=site
UR - mqw@umd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-14001-001
AN - 2005-14001-001
AU - Razzano, Lisa A.
AU - Cook, Judith A.
AU - Burke-Miller, Jane K.
AU - Mueser, Kim T.
AU - Pickett-Schenk, Susan A.
AU - Grey, Dennis D.
AU - Goldberg, Richard W.
AU - Blyler, Crystal R.
AU - Gold, Paul B.
AU - Leff, H. Stephen
AU - Lehman, Anthony F.
AU - Shafer, Michael S.
AU - Blankertz, Laura E.
AU - McFarlane, William R.
AU - Toprac, Marcia G.
AU - Carey, Martha Ann
T1 - Clinical factors associated with employment among people with severe mental illness: Findings from the employment intervention demonstration program.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 2005/11//
VL - 193
IS - 11
SP - 705
EP - 713
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Razzano, Lisa A., UIC Center on Mental Health Services Research and Policy, Department of Psychiatry, 104 South Michigan Ave., Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2005-14001-001. PMID: 16260923 Partial author list: First Author & Affiliation: Razzano, Lisa A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois, Chicago, IL, US. Release Date: 20060103. Correction Date: 20140714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Intervention; Mental Disorders; Psychosocial Factors; Supported Employment. Minor Descriptor: Achievement Potential; Program Development; Psychiatric Symptoms; Self-Regulation. Classification: Psychological Disorders (3210); Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Tests & Measures: Alcohol Use Scale; Drug Use Scale DOI: 10.1037/t31887-000; Positive and Negative Syndrome Scale DOI: 10.1037/t05056-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. Supplemental Data: Web Sites Internet. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2005.
AB - Research has shown that supported employment programs are effective in helping psychiatric outpatients achieve vocational outcomes, yet not all program participants are able to realize their employment goals. This study used 24 months of longitudinal data from a multisite study of supported employment interventions to examine the relationship of patient clinical factors to employment outcomes. Multivariate random regression analysis indicated that, even when controlling for an extensive series of demographic, study condition (experimental versus control), and work history covariates, clinical factors were associated with individuals' ability to achieve competitive jobs and to work 40 or more hours per month. Poor self-rated functioning, negative psychiatric symptoms, and recent hospitalizations were most consistently associated with failure to achieve these employment outcomes. These findings suggest ways that providers can tailor supported employment programs to achieve success with a diverse array of clinical subpopulations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical factors
KW - mental illness
KW - employment intervention
KW - employment programs
KW - self regulation
KW - psychiatric symptoms
KW - employment outcomes
KW - 2005
KW - Employment Status
KW - Intervention
KW - Mental Disorders
KW - Psychosocial Factors
KW - Supported Employment
KW - Achievement Potential
KW - Program Development
KW - Psychiatric Symptoms
KW - Self-Regulation
KW - 2005
DO - 10.1097/01.nmd.0000185939.11282.3e
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-14001-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-00501-008
AN - 2006-00501-008
AU - Crosby, Richard A.
AU - DiClemente, Ralph J.
AU - Wingood, Gina M.
AU - Salazar, Laura F.
AU - Rose, Eve
AU - Levine, David
AU - Brown, Larry
AU - Lescano, Celia
AU - Pugatch, David
AU - Flanigan, Timothy
AU - Fernandez, Isa
AU - Schlenger, William
AU - Silver, Barabra J.
T1 - Correlates of condom failure among adolescent males: An exploratory study.
JF - Preventive Medicine: An International Journal Devoted to Practice and Theory
JO - Preventive Medicine: An International Journal Devoted to Practice and Theory
JA - Prev Med
Y1 - 2005/11//Nov-Dec, 2005
VL - 41
IS - 5-6
SP - 873
EP - 876
CY - Netherlands
PB - Elsevier Science
SN - 0091-7435
AD - Crosby, Richard A., College of Public Health, University of Kentucky, 121 Washington Ave., Suite 111C, Lexington, KY, US, 40506-0003
N1 - Accession Number: 2006-00501-008. PMID: 16257047 Other Journal Title: Preventative Medicine: An International Journal Devoted to Practice & Theory. Partial author list: First Author & Affiliation: Crosby, Richard A.; Department of Behavioral Sciences and Health Education, Rollins School of Public Health, GA, US. Release Date: 20060306. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Condoms; Epidemiology; Errors; Psychosexual Behavior; Risk Factors. Minor Descriptor: Human Males. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Nov-Dec, 2005.
AB - Objective: To identify the prevalence and correlates of condom failure (defined as breakage or slipping off in the past 90 days) among a sample of adolescent males (15 to 21 years of age). Design: A cross-sectional study of 481 condom-using males residing in three US cities (Atlanta, GA, Providence RI, Miami FL). Data were collected, in the years 2000 and 2001, using audio computer-assisted self-interviewing technology. Prevalence ratios were used to determine the strength and significance of bivariate associations between ten assessed correlates and condom failure. Correlates achieving a screening level of significance were entered into a multivariate model that was used to calculate adjusted odds ratios (AOR). Results: Recent condom failure was reported by 34.1%. Younger adolescents were about one-third less likely to report condom failure (AOR = 0.66; P = 0.4). Adolescents reporting multiple sex partners were about 80% more likely to report failure (AOR = 1.84; P = 0.09). Adolescents indicating they had sex with someone on the same day they met the person were about 80% more likely to report failure (AOR = 1.77; P = 0.02). Finally, adolescents indicating recent problems obtaining condoms were about 70% more likely to report failure (AOR = 1.69; P = 0.1). Failure was not less common among those reporting a history of STD infection or those ever impregnating a partner. Conclusion: Because adolescent males may commonly experience condom failure, targeted clinic- and community-based programs designed to reduce user error could be an important aspect of preventing pregnancy and the spread of STDs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - condom failure
KW - prevalence
KW - risk factors
KW - 2005
KW - Condoms
KW - Epidemiology
KW - Errors
KW - Psychosexual Behavior
KW - Risk Factors
KW - Human Males
KW - 2005
DO - 10.1016/j.ypmed.2005.09.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00501-008&site=ehost-live&scope=site
UR - crosby@uky.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-11514-001
AN - 2005-11514-001
AU - Schackman, B. R.
AU - Finkelstein, R.
AU - Neukermans, C. P.
AU - Lewis, L.
AU - Eldred, L.
T1 - The cost of HIV medication adherence support interventions: Results of a cross-site evaluation.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2005/11//
VL - 17
IS - 8
SP - 927
EP - 937
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Schackman, B. R., Division of Outcomes and Effectiveness Research, Department of Public Health, Weill Medical College, Cornell University, 411 East 69th Street, New York, NY, US, 10021
N1 - Accession Number: 2005-11514-001. PMID: 16265786 Partial author list: First Author & Affiliation: Schackman, B. R.; Weill Medical College, Cornell University, New York, NY, US. Institutional Authors: Center for Adherence Support and Evaluation (Case) Team. Release Date: 20060103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Health Care Costs; HIV; Intervention; Treatment Compliance. Classification: Immunological Disorders (3291); Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov, 2005.
AB - The objective of this study was to determine the direct cost of HIV adherence support programmes participating in a cross-site evaluation in the US. Data on the frequency, type, and setting of adherence encounters; providers' professions; and adherence tools provided were collected for 1,122 patients enrolled in 13 interventions at 9 sites. The site staff estimated the average duration of each type of encounter and national wage rates were used for labour costs. The median (range) adherence encounters/year among interventions was 16.5 (4.3-104.6) per patient; encounters lasted 24.6 (8.9-40.9) minutes. Intervention direct cost was correlated with the average frequency of encounters (r = 0.57), but not with encounter duration or providers' professions. The median direct cost/month was $35 ($5-$58) per patient, and included direct provider costs (66%); incentives (17%); reminders and other tools (8%); and direct administrative time, provider transportation, training, and home delivery (9%). The median direct cost/month from a societal perspective, which includes patient time and travel costs, was $47 ($24-$114) per patient. Adherence interventions with moderate efficacy costing ≤$100/month have been estimated to meet a cost-effectiveness threshold that is generally accepted in the US. Payers should consider enhanced reimbursement for adherence support services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV medication adherence
KW - support interventions
KW - intervention cost
KW - cross site evaluation
KW - 2005
KW - Drug Therapy
KW - Health Care Costs
KW - HIV
KW - Intervention
KW - Treatment Compliance
KW - 2005
DO - 10.1080/09540120500100635
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-11514-001&site=ehost-live&scope=site
UR - brs2006@med.cornell.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Orloff, David G.
T1 - Fixed Combination Drugs for Cardiovascular Disease Risk Reduction: Regulatory Approach
JO - American Journal of Cardiology
JF - American Journal of Cardiology
Y1 - 2005/11/02/Nov2005 Supplement 1
VL - 96
M3 - Article
SP - 28
EP - 33
SN - 00029149
AB - The use of combination drug therapy for cardiovascular (CV) disease risk reduction is the established approach to multiple risk factor reduction. The spectrum of rational combination products in CV disease prevention and treatment alone is extremely broad. Development of fixed-dose combination drug products requires information beyond that needed for approval of single active ingredient products. Establishing the rationale and target populations for novel combinations, as well as the contributions of the component drugs to the claimed effects, and characterizing the pharmacokinetics, the pharmacodynamics, and clinical safety and efficacy of the combination are all necessary to support approval. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Cardiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG therapy
KW - DRUGS -- Physiological effect
KW - DISEASES -- Risk factors
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
N1 - Accession Number: 19484593; Orloff, David G. 1; Email Address: orloffd@cder.fda.gov; Affiliation: 1: US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Nov2005 Supplement 1, Vol. 96, p28; Subject Term: DRUG therapy; Subject Term: DRUGS -- Physiological effect; Subject Term: DISEASES -- Risk factors; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.amjcard.2005.08.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19484593&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106230617
T1 - Fixed combination drugs for cardiovascular disease risk reduction: regulatory approach.
AU - Orloff DG
Y1 - 2005/11/02/Nov2005 Supplement 1
N1 - Accession Number: 106230617. Language: English. Entry Date: 20070202. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Nov2005 Supplement 1. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0207277.
KW - Cardiovascular Diseases -- Drug Therapy
KW - Drug Therapy, Combination
KW - Government Regulations
KW - Health Policy
KW - Risk Assessment
KW - Risk Factors
KW - United States
SP - 28K
EP - 33K
JO - American Journal of Cardiology
JF - American Journal of Cardiology
JA - AM J CARDIOL
VL - 96
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0002-9149
AD - US Food and Drug Administration, Rockville, MD
U2 - PMID: 16291011.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106230617&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Moses-Kolko, Eydie L.
AU - Bogen, Debra
AU - Perel, James
AU - Wisner, Katherine L.
AU - Bregar, Amy
AU - Uhl, Kathleen
AU - Levin, Bob
T1 - Neonatal Signs After In Utero Exposure to Selective Serotonin Reuptake Inhibitors—Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/11/09/
VL - 294
IS - 18
M3 - Letter
SP - 2300
EP - 2301
SN - 00987484
AB - The article presents a reply to letters to the editor of "The Journal of the American Medical Association" regarding neonatal signs after late in vitro exposure to selective serotonin reuptake inhibitors. The letter discusses research by Moses-Kolko and colleagues in a previous issue of the journal.
KW - LETTERS to the editor
KW - NEONATOLOGY
KW - SEROTONIN uptake inhibitors
KW - Colic
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Serotonin Reuptake Inhibitors
N1 - Accession Number: 18778594; Moses-Kolko, Eydie L. 1; Email Address: mosesel@upmc.edu Bogen, Debra 1 Perel, James 1 Wisner, Katherine L. 1 Bregar, Amy 2 Uhl, Kathleen 3 Levin, Bob 3; Affiliation: 1: University of Pittsburgh School of Medicine, Pittsburgh, Pa 2: Princeton University, Princeton, NJ 3: Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Md; Source Info: 11/9/2005, Vol. 294 Issue 18, p2300; Subject Term: LETTERS to the editor; Subject Term: NEONATOLOGY; Subject Term: SEROTONIN uptake inhibitors; Author-Supplied Keyword: Colic; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: Prenatal Exposure Delayed Effects; Author-Supplied Keyword: Serotonin Reuptake Inhibitors; Number of Pages: 2p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18778594&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marks (Rupp), Heidi S.
AU - Anderson, Collin R.
T1 - Determination of putrescine and cadaverine in seafood (finfish and shellfish) by liquid chromatography using pyrene excimer fluorescence
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2005/11/11/
VL - 1094
IS - 1/2
M3 - Article
SP - 60
EP - 69
SN - 00219673
AB - Abstract: A liquid chromatography (LC) method is described for the easy determination of the biogenic diamines putrescine (PUT) and cadaverine (CAD) in canned tuna, frozen tuna loin, fresh mahimahi fillet, frozen raw shrimp, cooked lump crabmeat, and fresh and cold-smoked salmon. The method is also a useful screen for histamine (HTA). The method involves homogenization of fish tissue, extraction of biogenic amines into borate-trichloroacetic acid solution, centrifugation, and derivatization of supernatant with 1-pyrenebutanoic acid succinimidyl ester. The derivatized diamine species allow for the intramolecular excimer fluorescence of the pyrene moiety at a higher emission wavelength than is possible for the endogenous tissue monoamines, thus providing visual specificity of detection. All seafood species were fortified with 0.5, 1.0, 5.0, 10.0, and 15.0μg/g (ppm) of PUT and CAD. Determination was based on standard graphs for PUT and CAD using peak areas with standard solutions equivalent to 0.375, 1.0, 5.0, 10.0, and 20.0ppm in tissue. A set of five matrix controls (unfortified seafood tissue) were also analyzed; endogenous PUT was found in all samples except the canned tuna, and CAD found only in the shrimp, crab, and cold-smoked salmon. The background amines were thus subtracted prior to determining spike recovery. The intra-assay average recoveries ranged from 71 to 94% across species and spike levels. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Organic compounds
KW - Chromatographic analysis
KW - Liquid chromatography
KW - Cooking (Seafood)
KW - 1-Pyrenebutanoic acid succinimidyl ester
KW - Biogenic amines
KW - Cadaverine
KW - Crab
KW - Derivatization
KW - Histamine
KW - LC
KW - Mahimahi
KW - Putrescine
KW - Pyrene
KW - Salmon
KW - Shrimp
KW - Tuna
N1 - Accession Number: 18965489; Marks (Rupp), Heidi S.; Email Address: heidi.marks@fda.gov; Anderson, Collin R. 1; Affiliations: 1: US Food and Drug Administration, Seafood Products Research Center/Pacific Regional Laboratory Northwest, 22201 23rd Drive SE, Bothell, WA 98021, USA; Issue Info: Nov2005, Vol. 1094 Issue 1/2, p60; Thesaurus Term: Organic compounds; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Liquid chromatography; Subject Term: Cooking (Seafood); Author-Supplied Keyword: 1-Pyrenebutanoic acid succinimidyl ester; Author-Supplied Keyword: Biogenic amines; Author-Supplied Keyword: Cadaverine; Author-Supplied Keyword: Crab; Author-Supplied Keyword: Derivatization; Author-Supplied Keyword: Histamine; Author-Supplied Keyword: LC; Author-Supplied Keyword: Mahimahi; Author-Supplied Keyword: Putrescine; Author-Supplied Keyword: Pyrene; Author-Supplied Keyword: Salmon; Author-Supplied Keyword: Shrimp; Author-Supplied Keyword: Tuna; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chroma.2005.07.088
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=18965489&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mohler, Debra L.
AU - Downs, Jennifer R.
AU - Hurley-Predecki, Allison L.
AU - Sallman, Jennifer R.
AU - Gannett, Peter M.
AU - Xianglin Shi
T1 - DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes: Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)3CH3.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2005/11/11/
VL - 70
IS - 23
M3 - Article
SP - 9093
EP - 9102
SN - 00223263
AB - The photolysis of CpW(CO)3Me has been shown to produce methyl radicals and to cleave DNA in a single-stranded manner, and preliminary evidence implicated a carbon-centered radical in this process. In this work, the mechanism of strand scission in this reaction was determined to occur by hydrogen atom abstraction from the 4′- and 5′-positions of the deoxyribose moiety of the backbone of DNA. Additionally, in a side reaction that does not lead to frank strand scission, all four bases of DNA are methylated under these conditions; however, none of these base or backbone modifications lead to the formation of abasic sites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - HYDROXYL group
KW - CARBON
KW - HYDROGEN
KW - ATOMS
KW - DEOXYRIBOSE
KW - METALS
KW - PHOTOCHEMISTRY
N1 - Accession Number: 19120526; Mohler, Debra L. 1,2; Email Address: dmohler@emory.edu Downs, Jennifer R. 1 Hurley-Predecki, Allison L. 1 Sallman, Jennifer R. 1 Gannett, Peter M. 3 Xianglin Shi 4; Affiliation: 1: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322 2: James Madison University, Harrisonburg, VA 3: Department of Basic Pharmaceutical Sciences, West Virginia University, P.O. Box 9530, Morgantown, West Virginia 26506-9530 4: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Source Info: 11/11/2005, Vol. 70 Issue 23, p9093; Subject Term: DNA; Subject Term: HYDROXYL group; Subject Term: CARBON; Subject Term: HYDROGEN; Subject Term: ATOMS; Subject Term: DEOXYRIBOSE; Subject Term: METALS; Subject Term: PHOTOCHEMISTRY; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; NAICS/Industry Codes: 332811 Metal Heat Treating; Number of Pages: 10p; Illustrations: 5 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tournas, V.H.
AU - Katsoudas, Eugenia
T1 - Mould and yeast flora in fresh berries, grapes and citrus fruits
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2005/11/15/
VL - 105
IS - 1
M3 - Article
SP - 11
EP - 17
SN - 01681605
AB - Abstract: Fresh fruits are prone to fungal contamination in the field, during harvest, transport, marketing, and with the consumer. It is important to identify fungal contaminants in fresh fruits because some moulds can grow and produce mycotoxins on these commodities while certain yeasts and moulds can cause infections or allergies. In this study, 251 fresh fruit samples including several varieties of grapes, strawberries, blueberries, raspberries, blackberries, and various citrus fruits were surface-disinfected, incubated at room temperature for up to 14 days without supplemental media, and subsequently examined for mould and yeast growth. The level of contamination (percent of contaminated items/sample) varied depending on the type of fruit. All raspberry and blackberry samples were contaminated at levels ranging from 33% to 100%, whereas 95% of the blueberry samples supported mould growth at levels between 10% and 100% of the tested berries, and 97% of strawberry samples showed fungal growth on 33–100% of tested berries. The most common moulds isolated from these commodities were Botrytis cinerea, Rhizopus (in strawberries), Alternaria, Penicillium, Cladosporium and Fusarium followed by yeasts, Trichoderma and Aureobasidium. Thirty-five percent of the grape samples tested were contaminated and supported fungal growth; the levels of contamination ranged from 9% to 80%. The most common fungi spoiling grapes were Alternaria, B. cinerea and Cladosporium. Eighty-three percent of the citrus fruit samples showed fungal growth at levels ranging from 25% to 100% of tested fruits. The most common fungi in citrus fruits were Alternaria, Cladosporium, Penicillium, Fusarium and yeasts. Less common were Trichoderma, Geotrichum and Rhizopus. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Molds (Fungi)
KW - Citrus fruits
KW - Yeast
KW - Berries
KW - Grapes
KW - Moulds
KW - Yeasts
N1 - Accession Number: 18964047; Tournas, V.H. 1; Email Address: vtournas@cfsan.fda.gov; Katsoudas, Eugenia 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; 2: North East Regional Laboratory, Food and Drug Administration, 158-15 Liberty Ave., Jamaica, NY 11433, USA; Issue Info: Nov2005, Vol. 105 Issue 1, p11; Thesaurus Term: Molds (Fungi); Thesaurus Term: Citrus fruits; Subject Term: Yeast; Subject Term: Berries; Author-Supplied Keyword: Grapes; Author-Supplied Keyword: Moulds; Author-Supplied Keyword: Yeasts; NAICS/Industry Codes: 111334 Berry (except Strawberry) Farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111320 Citrus (except Orange) Groves; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2005.05.002
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Calvert, Geoffrey M.
AU - Alarcon, Walter
AU - Blondell, Jerome M.
T1 - Pesticide Exposure at Schools and Acute Illnesses—Reply.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/11/16/
VL - 294
IS - 19
M3 - Letter
SP - 2431
EP - 2431
SN - 00987484
AB - This letter replies to Drs. Kirrane and Hoffman about the validity of TESS data from U.S. poison control centers.
KW - LETTERS to the editor
KW - RESEARCH -- Methodology
KW - Child
KW - Environmental Exposure
KW - Pesticides
KW - Schools
N1 - Accession Number: 18892310; Calvert, Geoffrey M. 1 Alarcon, Walter 1; Email Address: walarcon@cdc.gov Blondell, Jerome M. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: U.S. Environmental Protection Agency, Washington, D.C.; Source Info: 11/16/2005, Vol. 294 Issue 19, p2431; Subject Term: LETTERS to the editor; Subject Term: RESEARCH -- Methodology; Author-Supplied Keyword: Child; Author-Supplied Keyword: Environmental Exposure; Author-Supplied Keyword: Pesticides; Author-Supplied Keyword: Schools; Number of Pages: 3/4p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Epstein, Suzanne L.
AU - Kong, Wing-pui
AU - Misplon, Julia A.
AU - Lo, Chia-Yun
AU - Tumpey, Terrence M.
AU - Xu, Ling
AU - Nabel, Gary J.
T1 - Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
JO - Vaccine
JF - Vaccine
Y1 - 2005/11/16/
VL - 23
IS - 46/47
M3 - Article
SP - 5404
EP - 5410
SN - 0264410X
AB - Abstract: Influenza epidemic and pandemic strains cannot be predicted with certainty. Current vaccines elicit antibodies effective against specific strains, but new strategies are urgently needed for protection against unexpected strains. DNA vaccines encoding conserved antigens protect animals against diverse subtypes, but their potency needs improvement. We tested DNA prime-recombinant adenoviral boost immunization to nucleoprotein (NP). Strong antibody and T cell responses were induced. Protection against challenge was T cell-dependent and substantially more potent than DNA vaccination alone. Importantly, vaccination protected against lethal challenge with highly pathogenic H5N1 virus. Thus, gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Influenza
KW - Immunoglobulins
KW - DNA vaccines
KW - Adenovirus vectors
KW - Animal models
KW - Conserved antigens
KW - H5N1 influenza
KW - Heterosubtypic immunity
N1 - Accession Number: 19012263; Epstein, Suzanne L. 1; Email Address: epsteins@cber.fda.gov; Kong, Wing-pui 2; Misplon, Julia A. 1; Lo, Chia-Yun 1; Tumpey, Terrence M. 3; Xu, Ling 2; Nabel, Gary J. 2; Affiliations: 1: Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; 2: Vaccine Research Center, National Institute for Allergy and Infectious Diseases, Rm. 4504, 40 Convent Dr., National Institutes of Health, Bethesda, MD 20892-3005, USA; 3: Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; Issue Info: Nov2005, Vol. 23 Issue 46/47, p5404; Thesaurus Term: Vaccination; Thesaurus Term: Influenza; Subject Term: Immunoglobulins; Subject Term: DNA vaccines; Author-Supplied Keyword: Adenovirus vectors; Author-Supplied Keyword: Animal models; Author-Supplied Keyword: Conserved antigens; Author-Supplied Keyword: H5N1 influenza; Author-Supplied Keyword: Heterosubtypic immunity; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.04.047
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Walker, Richard I.
AU - Van De Verg, Lillian L.
AU - Hall, Robert H.
AU - Schmitt, Clare K.
AU - Woo, Katherine
AU - Hale, Victoria
T1 - Enteric vaccines for pediatric use: Workshop summary
JO - Vaccine
JF - Vaccine
Y1 - 2005/11/16/
VL - 23
IS - 46/47
M3 - Article
SP - 5432
EP - 5439
SN - 0264410X
AB - Abstract: Diarrheal diseases remain a major cause of death in children under 5 in less developed countries (LDCs). Vaccine development and implementation offers the best near-term approach to alleviating this problem. For this reason, a workshop to examine the possibilities for making enteric vaccines available to meet the specific needs of children in LDCs was convened in Virginia on April 24–26, 2004. Discussants considered research and development needs, regulatory and business issues, and previous experiences with enteric vaccine development and implementation. No insurmountable roadblocks to progress in this area were noted, and the possibility currently exists that properly supported efforts will enable the realization of enteric vaccines for pediatric use. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Pathogenic microorganisms
KW - Pediatrics
KW - Diarrhea
KW - Enteric pathogens
KW - Pediatric vaccines
KW - Vaccine development and implementation
N1 - Accession Number: 19012267; Walker, Richard I. 1; Email Address: walkerri@cber.fda.gov; Van De Verg, Lillian L. 2; Hall, Robert H. 2; Schmitt, Clare K. 2; Woo, Katherine 3; Hale, Victoria 3; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-425), Rockville, MD 20851-1448, USA; 2: Enteric and Hepatic Diseases Branch, DMID, NIAID, NIH, 6600 Rockledge Drive, Bethesda, MD 20892-7630, USA; 3: Institute for OneWorld Health, 580 California Street, Suite 900, San Francisco, CA 94104, USA; Issue Info: Nov2005, Vol. 23 Issue 46/47, p5432; Thesaurus Term: Vaccination; Thesaurus Term: Pathogenic microorganisms; Subject Term: Pediatrics; Subject Term: Diarrhea; Author-Supplied Keyword: Enteric pathogens; Author-Supplied Keyword: Pediatric vaccines; Author-Supplied Keyword: Vaccine development and implementation; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.01.161
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Koturbash, Igor
AU - Pogribny, Igor
AU - Kovalchuk, Olga
T1 - Stable loss of global DNA methylation in the radiation-target tissue—A possible mechanism contributing to radiation carcinogenesis?
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2005/11/18/
VL - 337
IS - 2
M3 - Article
SP - 526
EP - 533
SN - 0006291X
AB - Abstract: Radiation-induced lymphomagenesis and leukemogenesis are complex processes involving both genetic and epigenetic changes. Although genetic alterations during radiation-induced lymphoma- and leukemogenesis are fairly well studied, the role of epigenetic changes has been largely overlooked. Rodent models are valuable tools for identifying molecular mechanisms of lymphoma and leukemogenesis. A widely used mouse model of radiation-induced thymic lymphoma is characterized by a lengthy “pre-lymphoma” period. Delineating molecular changes occurring during the pre-lymphoma period is crucial for understanding the mechanisms of radiation-induced leukemia/lymphoma development. In the present study, we investigated the role of radiation-induced DNA methylation changes in the radiation carcinogenesis target organ—thymus, and non-target organ—muscle. This study is the first report on the radiation-induced epigenetic changes in radiation-target murine thymus during the pre-lymphoma period. We have demonstrated that acute and fractionated whole-body irradiation significantly altered DNA methylation pattern in murine thymus leading to a massive loss of global DNA methylation. We have also observed that irradiation led to increased levels of DNA strand breaks 6h following the initial exposure. The majority of radiation-induced DNA strand breaks were repaired 1 month after exposure. DNA methylation changes, though, were persistent and significant radiation-induced DNA hypomethylation was observed in thymus 1 month after exposure. In sharp contrast to thymus, no significant persistent changes were noted in the non-target muscle tissue. The presence of stable DNA hypomethylation in the radiation-target tissue, even though DNA damage resulting from initial genotoxic radiation insult was repaired, suggests of the importance of epigenetic mechanisms in the development of radiation-related pathologies. The possible role of radiation-induced DNA hypomethylation in radiation-induced genome instability and aberrant gene expression in molecular etiology of thymic lymphomas is discussed. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - RADIATION
KW - DNA
KW - LYMPHOMAS
KW - METHYLATION
KW - DNA damage
KW - DNA methylation
KW - Radiation carcinogenesis
KW - Radiation-target organs
KW - Thymic lymphoma
N1 - Accession Number: 18778734; Koturbash, Igor 1 Pogribny, Igor 2 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta., Canada T1K 3M4 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Nov2005, Vol. 337 Issue 2, p526; Subject Term: NUCLEIC acids; Subject Term: RADIATION; Subject Term: DNA; Subject Term: LYMPHOMAS; Subject Term: METHYLATION; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Radiation carcinogenesis; Author-Supplied Keyword: Radiation-target organs; Author-Supplied Keyword: Thymic lymphoma; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.09.084
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Richard
T1 - The Vaccine Controversy: The History, Use, and Safety of Vaccinations.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2005/11/19/
VL - 331
IS - 7526
M3 - Book Review
SP - 1209
EP - 1209
SN - 09598146
AB - The article reviews the book "The Vaccine Controversy: The History, Use, and Safety of Vaccinations," by Kurt Link.
KW - VACCINATION
KW - NONFICTION
KW - LINK, Kurt
KW - VACCINE Controversy: The History, Use & Safety of Vaccinations, The (Book)
N1 - Accession Number: 18955241; Roberts, Richard 1; Email Address: roberts@doctors.org.uk; Affiliation: 1: National Public Health Service for Wales; Source Info: 11/19/2005, Vol. 331 Issue 7526, p1209; Subject Term: VACCINATION; Subject Term: NONFICTION; Reviews & Products: VACCINE Controversy: The History, Use & Safety of Vaccinations, The (Book); NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: LINK, Kurt; Number of Pages: 1/2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, C. Todd
AU - Ebel, Gregory D.
AU - Lanciotti, Robert S.
AU - Brault, Aaron C.
AU - Guzman, Hilda
AU - Siirin, Marina
AU - Lambert, Amy
AU - Parsons, Ray E.
AU - Beasley, David W.C.
AU - Novak, Robert J.
AU - Elizondo-Quiroga, Darwin
AU - Green, Emily N.
AU - Young, David S.
AU - Stark, Lillian M.
AU - Drebot, Michael A.
AU - Artsob, Harvey
AU - Tesh, Robert B.
AU - Kramer, Laura D.
AU - Barrett, Alan D.T.
T1 - Phylogenetic analysis of North American West Nile virus isolates, 2001–2004: Evidence for the emergence of a dominant genotype
JO - Virology
JF - Virology
Y1 - 2005/11/25/
VL - 342
IS - 2
M3 - Article
SP - 252
EP - 265
SN - 00426822
AB - Abstract: The distribution of West Nile virus has expanded in the past 6 years to include the 48 contiguous United States and seven Canadian provinces, as well as Mexico, the Caribbean islands, and Colombia. The suggestion of the emergence of a dominant genetic variant has led to an intensive analysis of isolates made across North America. We have sequenced the premembrane and envelope genes of 74 isolates and the complete genomes of 25 isolates in order to determine if a dominant genotype has arisen and to better understand how the virus has evolved as its distribution has expanded. Phylogenetic analyses revealed the continued presence of genetic variants that group in a temporally and geographically dependent manner and provide evidence that a dominant variant has emerged across much of North America. The implications of these findings are discussed as they relate to transmission and spread of the virus in the Western Hemisphere. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - EPIDEMIOLOGY
KW - MOLECULAR epidemiology
KW - GENETIC polymorphisms
KW - GENETIC research
KW - Flavivirus
KW - Molecular epidemiology
KW - Phylogenetics
KW - Viral evolution
KW - West Nile virus
N1 - Accession Number: 19008890; Davis, C. Todd 1 Ebel, Gregory D. 2 Lanciotti, Robert S. 3 Brault, Aaron C. 4 Guzman, Hilda 1 Siirin, Marina 1 Lambert, Amy 3 Parsons, Ray E. 5 Beasley, David W.C. 1 Novak, Robert J. 6 Elizondo-Quiroga, Darwin 7 Green, Emily N. 4 Young, David S. 2 Stark, Lillian M. 8 Drebot, Michael A. 9 Artsob, Harvey 9 Tesh, Robert B. 1 Kramer, Laura D. 2 Barrett, Alan D.T. 1; Email Address: abarrett@utmb.edu; Affiliation: 1: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77550-0609, USA 2: The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, Department of Biomedical Sciences, School of Public Health, The University at Albany, State University of New York, 5668 State Farm Road, Slingerlands, NY 12159, USA 3: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Services, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA 4: Center for Vector-borne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA 5: Mosquito Control Division, Harris County Public Health and Environmental Services, 3330 Old Spanish Trail, Bldg. D, Houston, TX 77021, USA 6: Illinois Natural History Survey, Champagne, IL 61820, USA 7: Universidad Autonoma de Nuevo Leon, San Nicolas de Los Garza, Nuevo Leon, Mexico 8: Florida Department of Health, Bureau of Laboratories-Tampa, 3602 Spectrum Boulevard, Tampa, FL 33612, USA 9: Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba, Canada; Source Info: Nov2005, Vol. 342 Issue 2, p252; Subject Term: GENES; Subject Term: EPIDEMIOLOGY; Subject Term: MOLECULAR epidemiology; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC research; Author-Supplied Keyword: Flavivirus; Author-Supplied Keyword: Molecular epidemiology; Author-Supplied Keyword: Phylogenetics; Author-Supplied Keyword: Viral evolution; Author-Supplied Keyword: West Nile virus; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.virol.2005.07.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Curns, Aaron T.
AU - Holman, Robert C.
AU - Sejvar, James J.
AU - Owings, Maria F.
AU - Schonberger, Lawrence B.
T1 - Infectious Disease Hospitalizations Among Older Adults in the United States From 1990 Through 2002.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2005/11/28/
VL - 165
IS - 21
M3 - Article
SP - 2514
EP - 2520
SN - 00039926
AB - Background To understand conditions associated with substantial morbidity among older adults (aged ≥65 years), we describe hospitalization rates and trends for overall infectious disease (ID) and for specific ID groups among older adults in the United States from January 1, 1990, through December 31, 2002. Methods The National Hospital Discharge Survey was used to generate hospitalization estimates from 1990 through 2002 for the US population of older adults. By using a comprehensive list of International Classification of Diseases, Ninth Revision, Clinical Modification codes associated with IDs, we identified and analyzed hospitalizations associated with specific ID and ID-related categories. Results There were approximately 21.4 million (SE, 636 000) ID hospitalizations among older adults from 1990 through 2002, and between 1990 through 1992 and 2000 through 2002, the ID hospitalization rate increased 13% from 449.4 to 507.9 hospitalizations per 10 000 older adults (P = .01). This increase was caused in part by the increasing relative contributions of patients aged 75 through 84 years and 85 years or older to the older adult ID hospitalization rate. Almost half of ID hospitalizations (46% [SE, 0.7%]) and ID-related hospital deaths (48% [SE, 1.6%]) among older adults were associated with lower respiratory tract infections from 2000 through 2002. Conclusions The hospitalization rate for IDs increased slightly among the older adult US population during the 13-year study and was associated with the aging of the older adult population. The reduction of ID hospitalization rates among older adults could help attenuate the anticipated increase in the number of hospitalizations among older adults and should be a high priority given the projected population growth among older adults in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Internal Medicine is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases
KW - DISEASES
KW - INFECTION
KW - HOSPITAL care
KW - ADULTS
KW - PATIENTS
KW - UNITED States
KW - Communicable Diseases
KW - Elderly
KW - Epidemiologic Studies
KW - Hospitalization
KW - United States
N1 - Accession Number: 19070936; Curns, Aaron T. 1 Holman, Robert C. 1 Sejvar, James J. 1 Owings, Maria F. 2 Schonberger, Lawrence B. 1; Affiliation: 1: Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Ga 2: Hospital Care Statistics Branch, Division of Healthcare Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, US Department of Health and Human Services, Hyattsville, Md; Source Info: 11/28/2005, Vol. 165 Issue 21, p2514; Subject Term: COMMUNICABLE diseases; Subject Term: DISEASES; Subject Term: INFECTION; Subject Term: HOSPITAL care; Subject Term: ADULTS; Subject Term: PATIENTS; Subject Term: UNITED States; Author-Supplied Keyword: Communicable Diseases; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Epidemiologic Studies; Author-Supplied Keyword: Hospitalization; Author-Supplied Keyword: United States; Number of Pages: 7p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106159247
T1 - Infectious disease hospitalizations among older adults in the United States from 1990 through 2002.
AU - Curns AT
AU - Holman RC
AU - Sejvar JJ
AU - Owings MF
AU - Schonberger LB
Y1 - 2005/11/28/
N1 - Accession Number: 106159247. Language: English. Entry Date: 20070928. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Communicable Diseases -- Epidemiology -- United States
KW - Hospitalization
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Demography
KW - Female
KW - Hospital Mortality -- Trends -- United States
KW - Hospitalization -- Trends -- United States
KW - Incidence
KW - Male
KW - Retrospective Design
KW - Surveys
KW - United States
KW - Human
SP - 2514
EP - 2520
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 165
IS - 21
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Ga
U2 - PMID: 16314549.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106159247&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kevin P. Mulvey
T1 - Using the Internet to Measure Program Performance.
JO - American Journal of Evaluation
JF - American Journal of Evaluation
Y1 - 2005/12//
VL - 26
IS - 4
M3 - Article
SP - 587
EP - 597
SN - 10982140
AB - The Internet and World Wide Web are increasingly used to accelerate progress in a variety of fields. These applications go beyond the traditional technology- or computer-related fields and have expanded to nontechnical fields, which have benefited greatly from the use of the Web as a data-gathering and management support tool. The purpose of this article is to examine the Web’s use by a federal funding agency and its grantees for performance measurement and program monitoring. The analysis is based on the Center for Substance Abuse Treatment’s (CSAT) implementation of a Web-based data entry and reporting system. This system is used both as a mechanism for monitoring CSAT’s grant portfolios and as a tool to manage performance. The authors conclude with a discussion of the issues surrounding the effectiveness and efficiency of using the Web to measure and monitor program performance. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Evaluation is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERNET
KW - WORLD Wide Web
KW - ELECTRONIC data processing
KW - PROJECT management
N1 - Accession Number: 20284372; Kevin P. Mulvey 1; Affiliation: 1: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, kevin.mulvey@samhsa.hhs.gov. Westat. Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration. Westat; Source Info: Dec2005, Vol. 26 Issue 4, p587; Subject Term: INTERNET; Subject Term: WORLD Wide Web; Subject Term: ELECTRONIC data processing; Subject Term: PROJECT management; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 541611 Administrative Management and General Management Consulting Services; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 541619 Other management consulting services; NAICS/Industry Codes: 519130 Internet Publishing and Broadcasting and Web Search Portals; NAICS/Industry Codes: 517110 Wired Telecommunications Carriers; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sequist, Thomas D.
AU - Ayanian, John Z.
AU - Cullen, Theresa
T1 - Information Technology as a Tool to Improve the Quality of American Indian Health Care.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2005/12//
VL - 95
IS - 12
M3 - Article
SP - 2173
EP - 2179
PB - American Public Health Association
SN - 00900036
AB - The American Indian/ Alaska Native population experiences a disproportionate burden of disease across a spectrum of conditions. While the recent National Healthcare Disparities Report highlighted differences in quality of care among racial and ethnic groups, there was only very limited information available for American Indians. The Indian Health Service (IHS) is currently enhancing its information systems to improve the measurement of health care quality as well as to support quality improvement initiatives. We summarize current knowledge regarding health care quality for American Indians, highlighting the variation in reported measures in the existing literature. We then discuss how the IHS is using information systems to produce standardized performance measures and present future directions for improving American Indian health care quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE Americans
KW - POPULATION
KW - INFORMATION resources management
KW - MEDICAL care -- Quality control
KW - STANDARDIZATION
KW - HEALTH—GENERAL
N1 - Accession Number: 19164996; Sequist, Thomas D. 1,2; Email Address: tsequist@partners.org Ayanian, John Z. 1,2 Cullen, Theresa 3; Affiliation: 1: Department of Health Care Policy, Harvard Medical School 2: Division of General Medicine, Brigham and Women's Hospital, Boston, Mass. 3: Office of Information Technology, Indian Health Service, Tucson, Ariz.; Source Info: Dec2005, Vol. 95 Issue 12, p2173; Subject Term: NATIVE Americans; Subject Term: POPULATION; Subject Term: INFORMATION resources management; Subject Term: MEDICAL care -- Quality control; Subject Term: STANDARDIZATION; Author-Supplied Keyword: HEALTH—GENERAL; NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 7p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article; Full Text Word Count: 5374
L3 - 10.2105/AJPH.2004.052985
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106271064
T1 - Economic evaluation of the 7-vaccine routine childhood immunization schedule in the United States, 2001.
AU - Zhou F
AU - Santoli J
AU - Messonnier ML
AU - Yusuf HR
AU - Shefer A
AU - Chu SY
AU - Rodewald L
AU - Harpaz R
Y1 - 2005/12//
N1 - Accession Number: 106271064. Language: English. Entry Date: 20070420. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9422751.
KW - Immunization Programs -- Economics
KW - Immunization Schedule
KW - Immunization -- Economics
KW - Models, Statistical
KW - Vaccines -- Economics
KW - Chickenpox -- Epidemiology
KW - Chickenpox -- Prevention and Control
KW - Child
KW - Child, Preschool
KW - Comparative Studies
KW - Costs and Cost Analysis
KW - Diphtheria -- Epidemiology
KW - Diphtheria -- Prevention and Control
KW - Haemophilus Infections -- Epidemiology
KW - Haemophilus Infections -- Prevention and Control
KW - Health Care Costs
KW - Incidence
KW - Infant
KW - Measles -- Epidemiology
KW - Measles -- Prevention and Control
KW - Mumps -- Epidemiology
KW - Mumps -- Prevention and Control
KW - Poliomyelitis -- Epidemiology
KW - Poliomyelitis -- Prevention and Control
KW - Prospective Studies
KW - Retrospective Design
KW - Rubella -- Epidemiology
KW - Rubella -- Prevention and Control
KW - Tetanus -- Epidemiology
KW - Tetanus -- Prevention and Control
KW - United States
KW - Vaccines -- Administration and Dosage
KW - Whooping Cough -- Epidemiology
KW - Whooping Cough -- Prevention and Control
KW - Human
SP - 1136
EP - 1144
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 159
IS - 12
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - National Immunization Program, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Ga
U2 - PMID: 16330737.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Joanna D. Moody
AU - James P. Freeman
AU - Carl E. Cerniglia
T1 - Degradation of benz[a]anthracene by Mycobacterium vanbaalenii strain PYR-1.
JO - Biodegradation
JF - Biodegradation
Y1 - 2005/12//
VL - 16
IS - 6
M3 - Article
SP - 513
EP - 526
SN - 09239820
AB - Abstract Cultures of Mycobacterium vanbaalenii strain PYR-1 grown in mineral salts medium and nutrients in the presence of benz[a]anthracene metabolized 15% of the added benz[a]anthracene after 12?days of incubation. Neutral and acidic ethyl acetate extractable metabolites were isolated and characterized by high performance liquid chromatography (HPLC) and uv–visible absorption, gas chromatography/mass (GC/MS) and nuclear magnetic resonance (NMR) spectral analysis. Trimethylsilylation of the metabolites?followed by GC/MS analysis facilitated identification of metabolites. The characterization of metabolites indicated that M. vanbaalenii initiated attack of benz[a]anthracene at the C-1,2-, C-5,6-, C-7,12- and C-10,11-positions to form dihydroxylated and methoxylated intermediates. The major site of enzymatic attack was in the C-10, C-11 positions. Subsequent ortho- and meta-cleavage of each of the aromatic rings led to the accumulation of novel ring-fission metabolites in the medium. The major metabolites identified were 3-hydrobenzo[f]isobenzofuran-1-one (3.2%), 6-hydrofuran[3,4-g]chromene-2,8-dione (1.3%), benzo[g]chromene-2-one (1.7%), naphtho[2,1-g]chromen-10-one (48.1%), 10-hydroxy-11-methoxybenz[a]anthracene (9.3%), and 10,11-dimethoxybenz[a]anthracene (36.4%). Enzymatic attack at the C-7 and C-12 positions resulted in the formation of benz[a]anthracene-7,12-dione, 1-(2-hydroxybenzoyl)-2-naphthoic acid, and 1-benzoyl-2-naphthoic acid. A phenyl-naphthyl metabolite, 3-(2-carboxylphenyl)-2-naphthoic acid, was formed when M. vanbaalenii was incubated with benz[a]anthracene cis-5,6-dihydrodiol, indicating ortho-cleavage of 5,6-dihydroxybenz[a]anthracene. A minor amount of 5,6-dimethoxybenz[a]anthracene was also formed. The data extend and propose novel pathways for the bacterial metabolism of benz[a]anthracene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biodegradation is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biodegradation
KW - Benzanthracenes
KW - Mycobacterium
KW - Bacteria -- Metabolism
N1 - Accession Number: 20386815; Joanna D. Moody 1; James P. Freeman 2; Carl E. Cerniglia 1; Affiliations: 1: Division of Microbiology National Center for Toxicological Research, U.S. Food and Drug Administration 72079-9502 Jefferson, Arkansas USA; 2: Division of Chemistry National Center for Toxicological Research, U.S. Food and Drug Administration 72079-9502 Jefferson, Arkansas USA; Issue Info: Dec2005, Vol. 16 Issue 6, p513; Thesaurus Term: Biodegradation; Thesaurus Term: Benzanthracenes; Subject Term: Mycobacterium; Subject Term: Bacteria -- Metabolism; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Filipovich, Alexandra H.
AU - Weisdorf, Daniel
AU - Pavletic, Steven
AU - Socie, Gerard
AU - Wingard, John R.
AU - Lee, Stephanie J.
AU - Martin, Paul
AU - Chien, Jason
AU - Przepiorka, Donna
AU - Couriel, Daniel
AU - Cowen, Edward W.
AU - Dinndorf, Patricia
AU - Farrell, Ann
AU - Hartzman, Robert
AU - Henslee-Downey, Jean
AU - Jacobsohn, David
AU - McDonald, George
AU - Mittleman, Barbara
AU - Rizzo, J. Douglas
AU - Robinson, Michael
T1 - National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2005/12//
VL - 11
IS - 12
M3 - Article
SP - 945
EP - 956
SN - 10838791
AB - Abstract: This consensus document is intended to serve 3 functions. First, it standardizes the criteria for diagnosis of chronic graft-versus-host disease (GVHD). Second, it proposes a new clinical scoring system (0-3) that describes the extent and severity of chronic GVHD for each organ or site at any given time, taking functional impact into account. Third, it proposes new guidelines for global assessment of chronic GVHD severity that are based on the number of organs or sites involved and the degree of involvement in affected organs (mild, moderate, or severe). Diagnosis of chronic GVHD requires the presence of at least 1 diagnostic clinical sign of chronic GVHD (e.g., poikiloderma or esophageal web) or the presence of at least 1 distinctive manifestation (e.g., keratoconjunctivitis sicca) confirmed by pertinent biopsy or other relevant tests (e.g., Schirmer test) in the same or another organ. Furthermore, other possible diagnoses for clinical symptoms must be excluded. No time limit is set for the diagnosis of chronic GVHD. The Working Group recognized 2 main categories of GVHD, each with 2 subcategories. The acute GVHD category is defined in the absence of diagnostic or distinctive features of chronic GVHD and includes (1) classic acute GVHD occurring within 100 days after transplantation and (2) persistent, recurrent, or late acute GVHD (features of acute GVHD occurring beyond 100 days, often during withdrawal of immune suppression). The broad category of chronic GVHD includes (1) classic chronic GVHD (without features or characteristics of acute GVHD) and (2) an overlap syndrome in which diagnostic or distinctive features of chronic GVHD and acute GVHD appear together. It is currently recommended that systemic therapy be considered for patients who meet criteria for chronic GVHD of moderate to severe global severity. [Copyright &y& Elsevier]
AB - Copyright of Biology of Blood & Marrow Transplantation is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL experimentation on humans
KW - GOVERNMENT policy
KW - CORNEA -- Diseases
KW - CLINICAL pathology
KW - Allogeneic hematopoietic cell transplantation
KW - Chronic graft-versus-host disease
KW - Consensus
KW - Diagnosis
KW - Staging
N1 - Accession Number: 19186241; Filipovich, Alexandra H. 1; Email Address: lisa.filipovich@cchmc.org Weisdorf, Daniel 2 Pavletic, Steven 3 Socie, Gerard 4 Wingard, John R. 5 Lee, Stephanie J. 6 Martin, Paul 7 Chien, Jason 7 Przepiorka, Donna 8 Couriel, Daniel 9 Cowen, Edward W. 3 Dinndorf, Patricia 10 Farrell, Ann 10 Hartzman, Robert 11 Henslee-Downey, Jean 12 Jacobsohn, David 13 McDonald, George 7 Mittleman, Barbara 14 Rizzo, J. Douglas 15 Robinson, Michael 16; Affiliation: 1: Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 2: University of Minnesota, Minneapolis, Minnesota 3: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 4: Hopital Saint Louis, Paris, France 5: University of Florida Shands Cancer Center, Gainsville, Florida 6: Dana-Farber Cancer Institute, Boston, Massachusetts 7: Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 8: University of Tennessee, Memphis, Tennessee 9: University of Texas M.D. Anderson Cancer Center, Houston, Texas 10: US Food and Drug Administration, Rockville, Maryland 11: C.W. Bill Young/Department of Defense Marrow Donor Recruitment and Research Program, Naval Medical Research Center, Silver Spring, Maryland 12: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 13: Children’s Memorial Hospital, Northwestern University School of Medicine, Chicago, Illinois 14: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 15: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin 16: National Eye Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Dec2005, Vol. 11 Issue 12, p945; Subject Term: MEDICAL experimentation on humans; Subject Term: GOVERNMENT policy; Subject Term: CORNEA -- Diseases; Subject Term: CLINICAL pathology; Author-Supplied Keyword: Allogeneic hematopoietic cell transplantation; Author-Supplied Keyword: Chronic graft-versus-host disease; Author-Supplied Keyword: Consensus; Author-Supplied Keyword: Diagnosis; Author-Supplied Keyword: Staging; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bbmt.2005.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wouters, Karlijn A.
AU - Kremer, Leontien C. M.
AU - Miller, Tracie L.
AU - Herman, Eugene H.
AU - Lipshultz, Steven E.
T1 - Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2005/12//
VL - 131
IS - 5
M3 - Article
SP - 561
EP - 578
PB - Wiley-Blackwell
SN - 00071048
AB - Over the last 40 years, great progress has been made in treating childhood and adult cancers. However, this progress has come at an unforeseen cost, in the form of emerging long-term effects of anthracycline treatment. A major complication of anthracycline therapy is its adverse cardiovascular effects. If these cardiac complications could be reduced or prevented, higher doses of anthracyclines could potentially be used, thereby further increasing cancer cure rates. Moreover, as the incidence of cardiac toxicity resulting in congestive heart failure or even heart transplantation dropped, the quality and extent of life for cancer survivors would improve. We review the proposed mechanisms of action of anthracyclines and the consequences associated with anthracycline treatment in children and adults. We summarise the most promising current strategies to limit or prevent anthracycline-induced cardiotoxicity, as well as possible strategies to prevent existing cardiomyopathy from worsening. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER in children
KW - CANCER in adolescence
KW - ANTHRACYCLINES
KW - CARDIOMYOPATHIES
KW - HEART failure
KW - CANCER patients
KW - HEART transplantation
KW - anthracyclines
KW - cancer
KW - cardioprotective agents
KW - myocardial damage
KW - prevention
N1 - Accession Number: 18881952; Wouters, Karlijn A. 1,2 Kremer, Leontien C. M. 3 Miller, Tracie L. 2,4 Herman, Eugene H. 5 Lipshultz, Steven E. 4; Email Address: slipshultz@med.miami.edu; Affiliation: 1: Division of Paediatrics, Vrije Universiteit Medical Centre, Amsterdam, the Netherlands 2: Division of Pediatric Clinical Research, University of Miami, Miller School of Medicine, Miami, FL, USA 3: Department of Paediatric Oncology, Academic Medical Centre, Emma Children’s Hospital, Amsterdam, the Netherlands 4: Department of Pediatrics, University of Miami, Miller School of Medicine, Holtz Children’s Hospital of the University of Miami-Jackson Memorial Medical Centre, and the Sylvester Comprehensive Cancer Center, Miami, FL, USA 5: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration (HFD-910), Silver Spring, MD, USA; Source Info: Dec2005, Vol. 131 Issue 5, p561; Subject Term: CANCER in children; Subject Term: CANCER in adolescence; Subject Term: ANTHRACYCLINES; Subject Term: CARDIOMYOPATHIES; Subject Term: HEART failure; Subject Term: CANCER patients; Subject Term: HEART transplantation; Author-Supplied Keyword: anthracyclines; Author-Supplied Keyword: cancer; Author-Supplied Keyword: cardioprotective agents; Author-Supplied Keyword: myocardial damage; Author-Supplied Keyword: prevention; Number of Pages: 18p; Illustrations: 1 Diagram, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2141.2005.05759.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Conway, G. A.
T1 - COMMENTARY.
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
Y1 - 2005/12//
VL - 39
IS - 12
M3 - Article
SP - 901
EP - 901
SN - 03063674
AB - This article presents the author's comment on the paper "Frostbite: Incidence and Predisposing Factors in Mountaineers." This paper provides a very interesting report of a problem faced by mountaineers and workers in cold environments around the world: frostbite. The authors' disquisition on the costs of obtaining proper protective boots and clothing posing difficulty in a developing nation is trenchant. Their advice for climbers to learn more about thermal properties of locally available materials and fabrics and about thermal layering is an excellent and inventive response to this problem. The author thinks that this paper and any germane educational materials on equipment, clothing, and frostbite prevention should be distributed to the climbing clubs and workers who must work outside during the winter.
KW - FROSTBITE
KW - COLD (Temperature) -- Physiological effect
KW - MOUNTAINEERING
KW - HIKING
KW - ATHLETES
KW - DISEASE susceptibility
N1 - Accession Number: 19142019; Conway, G. A. 1; Email Address: gconway@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, US Centers for Disease Control, 4230 University Dr #310, Anchorage, AK 99508.; Source Info: Dec2005, Vol. 39 Issue 12, p901; Subject Term: FROSTBITE; Subject Term: COLD (Temperature) -- Physiological effect; Subject Term: MOUNTAINEERING; Subject Term: HIKING; Subject Term: ATHLETES; Subject Term: DISEASE susceptibility; NAICS/Industry Codes: 711219 Other Spectator Sports; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106464037
T1 - Working in noise with a hearing loss: perceptions from workers, supervisors, and hearing conservation program managers.
AU - Morata TC
AU - Themann CL
AU - Randolph RF
AU - Verbsky BL
AU - Byrne DC
AU - Reeves ER
Y1 - 2005/12//
N1 - Accession Number: 106464037. Language: English. Entry Date: 20060630. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8005585.
KW - Employment of Disabled
KW - Hearing Disorders
KW - Job Performance
KW - Noise
KW - Occupational Safety
KW - Work Environment
KW - Adult
KW - Attitude to Disability
KW - Blacks
KW - Communication
KW - Ear Protective Devices
KW - Employee Attitudes
KW - Employee, Disabled
KW - Female
KW - Focus Groups
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Interviews
KW - Job Accommodation
KW - Male
KW - Middle Age
KW - Occupational Exposure -- Prevention and Control
KW - Ohio
KW - Pennsylvania
KW - Quality of Life
KW - Self Report
KW - Stress, Occupational
KW - Supervisors and Supervision
KW - Whites
KW - Human
SP - 529
EP - 545
JO - Ear & Hearing (01960202)
JF - Ear & Hearing (01960202)
JA - EAR HEAR
VL - 26
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Workers with hearing loss face special problems, especially when working in noise. However, conventional hearing conservation practices do not distinguish between workers with normal hearing versus impaired hearing. This study collected information from workers with self-reported noise exposure and hearing loss, supervisors of such workers, and hearing conservation program managers through focus groups and in-depth interviews to evaluate their perspectives on the impact of hearing loss on safety and job performance, the use of hearing protection, and information needed to appropriately manage hearing-impaired workers who work in noisy environments. RESULTS: Concerns about working in noise with a hearing loss could be grouped into the following 10 categories: impact on job performance, impact on job safety, impaired ability to hear warning signals, impaired ability to monitor equipment, interference with communication, stress and/or fatigue, impaired communication caused by hearing protector use, reduced ability to monitor the environment as the result of hearing protector use, concerns about future quality of life, and concerns about future employability. Mostly, there was an agreement between the perceptions of workers, supervisors, and hearing conservation program managers regarding difficulties associated with hearing loss and consequent needs. These findings suggest that noise-exposed workers with hearing loss face many of the same problems reported in the literature by noise-exposed workers with normal hearing, with additional concerns primarily about job safety as the result of a reduced ability to hear environmental sounds, warning signals, and so forth. CONCLUSIONS: The study outlines potential challenges regarding job safety and hearing conservation practices for noise-exposed, hearing-impaired workers. Awareness of these issues is a necessary first step toward providing appropriate protective measures for noise-exposed, hearing-impaired workers.
SN - 0196-0202
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop C-27, Cincinnati, OH 45226-1998; tmorata@cdc.gov
U2 - PMID: 16377991.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Pérez-Arellano, Jose-Luis
AU - Luzardo, Octavio P.
AU - Brito, Ana Pérez
AU - Cabrera, Michele Hernández
AU - Zumbado, Manuel
AU - Carranza, Cristina
AU - Angel-Moreno, Alfonso
AU - Dickey, Robert W.
AU - Boada, Luis D.
T1 - Ciguatera Fish Poisoning, Canary Islands.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2005/12//
VL - 11
IS - 12
M3 - Letter
SP - 1981
EP - 1982
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - A letter to the editor is presented in response to the study "Ciguatera Fish Poisoning, Canary Islands," by Octavio P. Luzardo, Ana Pérez Brito et al., in the December 2004 issue.
KW - TOXICOLOGY
KW - Letters to the editor
KW - Poisonous fishes
N1 - Accession Number: 18927350; Pérez-Arellano, Jose-Luis 1,2; Email Address: jlperez@dcmq.ulpgc.es; Luzardo, Octavio P. 1; Brito, Ana Pérez 3; Cabrera, Michele Hernández 1,2; Zumbado, Manuel 1; Carranza, Cristina 1,2; Angel-Moreno, Alfonso 1,2; Dickey, Robert W. 4; Boada, Luis D. 1; Affiliations: 1: University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; 2: Hospital Universitario Insular de Gran Canaria (Canary Health Service), Las Palmas de Gran Canaria, Spain; 3: Hospital de Fuerteventura, Puerto del Rosario, Spain; 4: Gulf Coast Seafood Laboratory (Food and Drug Administration), Dauphin Island, Alabama, USA; Issue Info: Dec2005, Vol. 11 Issue 12, p1981; Thesaurus Term: TOXICOLOGY; Subject Term: Letters to the editor; Subject Term: Poisonous fishes; Number of Pages: 2p; Document Type: Letter
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TY - JOUR
AU - Lewis, Lauren
AU - Onsongo, Mary
AU - Njapau, Henry
AU - Schurz-Rogers, Helen
AU - Luber, George
AU - Kieszak, Stephanie
AU - Nyamongo, Jack
AU - Backer, Lorraine
AU - Dahiye, Abdikher Mohamud
AU - Misore, Ambrose
AU - DeCock, Kevin
AU - Rubin, Carol
T1 - Aflatoxin Contamination of Commercial Maize Products during an Outbreak of Acute Aflatoxicosis in Eastern and Central Kenya.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/12//
VL - 113
IS - 12
M3 - Article
SP - 1763
PB - Superintendent of Documents
SN - 00916765
AB - In April 2004, one of the largest aflatoxicosis outbreaks occurred in rural Kenya, resulting in 317 cases and 125 deaths. Aflatoxin-contaminated homegrown maize was the source of the outbreak, but the extent of regional contamination and status of maize in commercial markets (market maize) were unknown. We conducted a cross-sectional survey to assess the extent of market maize contamination and evaluate the relationship between market maize aflatoxin and the aflatoxicosis outbreak. We surveyed 65 markets and 243 maize vendors and collected 350 maize products in the most affected districts. Fifty-five percent of maize products had aflatoxin levels greater than the Kenyan regulatory limit of 20 ppb, 35% had levels > 100 ppb, and 7% had levels > 1,000 ppb. Makueni, the district with the most aflatoxicosis case-patients, had significantly higher market maize aflatoxin than did Thika, the study district with fewest case-patients (geometric mean aflatoxin = 52.91 ppb vs. 7.52 ppb, p = 0.0004). Maize obtained from local farms in the affected area was significantly more likely to have aflatoxin levels > 20 ppb compared with maize bought from other regions of Kenya or other countries (odds ratio = 2.71; 95% confidence interval, 1.12-6.59). Contaminated homegrown maize bought from local farms in the affected area entered the distribution system, resulting in widespread aflatoxin contamination of market maize. Contaminated market maize, purchased by farmers after their homegrown supplies are exhausted, may represent a source of continued exposure to aflatoxin. Efforts to successfully interrupt exposure to aflatoxin during an outbreak must consider the potential role of the market system in sustaining exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aflatoxins
KW - Mycotoxins
KW - Epidemics
KW - Epidemiology
KW - Corn
KW - Agriculture
KW - Fungal metabolites
KW - Microbial toxins
KW - Kenya
KW - aflatoxicosis
KW - aflatoxin
KW - corn
KW - food safety
KW - maize
KW - mold
KW - mycotoxin
N1 - Accession Number: 19030646; Lewis, Lauren 1; Email Address: lwb6@cdc.gov; Onsongo, Mary 2; Njapau, Henry 3; Schurz-Rogers, Helen 1; Luber, George 1; Kieszak, Stephanie 1; Nyamongo, Jack 4; Backer, Lorraine 1; Dahiye, Abdikher Mohamud 5; Misore, Ambrose 6; DeCock, Kevin 7; Rubin, Carol 1; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Chamblee, Georgia, USA; 2: Foreign Agricultural Service, U.S. Department of Agriculture, Nairobi, Kenya; 3: Office of Plant and Dairy Foods, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA; 4: Kenya National Public Health Laboratory, Nairobi, Kenya; 5: Kenya Field Epidemiology and Laboratory Training Program, Kenya Ministry of Health, Nairobi, Kenya; 6: Preventive and Promotive Health, Kenya Ministry of Health, Nairobi, Kenya; 7: Centers for Disease Control and Prevention, Kenya Office, Nairobi, Kenya; Issue Info: Dec2005, Vol. 113 Issue 12, p1763; Thesaurus Term: Aflatoxins; Thesaurus Term: Mycotoxins; Thesaurus Term: Epidemics; Thesaurus Term: Epidemiology; Thesaurus Term: Corn; Thesaurus Term: Agriculture; Subject Term: Fungal metabolites; Subject Term: Microbial toxins; Subject: Kenya; Author-Supplied Keyword: aflatoxicosis; Author-Supplied Keyword: aflatoxin; Author-Supplied Keyword: corn; Author-Supplied Keyword: food safety; Author-Supplied Keyword: maize; Author-Supplied Keyword: mold; Author-Supplied Keyword: mycotoxin; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 5p; Illustrations: 3 Charts, 1 Map; Document Type: Article
L3 - 10.1289/ehp.7998
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TY - JOUR
AU - Azziz-Baumgartner, Eduardo
AU - Lindblade, Kimberly
AU - Gieseker, Karen
AU - Rogers, Helen Schurz
AU - Kieszak, Stephanie
AU - Njapau, Henry
AU - Schleicher, Rosemary
AU - McCoy, Leslie F.
AU - Misore, Ambrose
AU - de Cook, Kevin
AU - Rubin, Carol
AU - Slutsker, Laurence
T1 - Case–Control Study of an Acute Aflatoxicosis Outbreak, Kenya, 2004.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2005/12//
VL - 113
IS - 12
M3 - Article
SP - 1779
PB - Superintendent of Documents
SN - 00916765
AB - OBJECTIVES: During January–June 2004, an aflatoxicosis outbreak in eastern Kenya resulted in 317 cases and 125 deaths. We conducted a case–control study to identify risk factors for contamination of implicated maize and, for the first time, quantitated biomarkers associated with acute aflatoxicosis. DESIGN: We administered questionnaires regarding maize storage and consumption and obtained maize and blood samples from participants. PARTICIPANTS: We recruited 40 case-patients with aflatoxicosis and 80 randomly selected controls to participate in this study. EVALUATIONS/MEASUREMENTS: We analyzed maize for total aflatoxins and serum for aflatoxin B1–lysine albumin adducts and hepatitis B surface antigen. We used regression and survival analyses to explore the relationship between aflatoxins, maize consumption, hepatitis B surface antigen, and case status. RESULTS: Homegrown (not commercial) maize kernels from case households had higher concentrations of aflatoxins than did kernels from control households [geometric mean (GM) = 354.53 ppb vs. 44.14 ppb; p = 0.04]. Serum adduct concentrations were associated with time from jaundice to death [adjusted hazard ratio = 1.3; 95% confidence interval (CI), 1.04–1.6]. Case patients had positive hepatitis B titers [odds ratio (OR) = 9.8; 95% CI, 1.5–63.1] more often than controls. Case patients stored wet maize (OR = 3.5; 95% CI, 1.2–10.3) inside their homes (OR = 12.0; 95% CI, 1.5–95.7) rather than in granaries more often than did controls. CONCLUSION: Aflatoxin concentrations in maize, serum aflatoxin B1–lysine adduct concentrations, and positive hepatitis B surface antigen titers were all associated with case status. RELEVANCE: The novel methods and risk factors described may help health officials prevent future outbreaks of aflatoxicosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aflatoxins
KW - Mycotoxins
KW - Epidemics
KW - Epidemiology
KW - Mycotoxins -- Physiological effect
KW - Microbial toxins
KW - Fungal metabolites
KW - Kenya
KW - aflatoxicosis
KW - aflatoxin
KW - albumin adducts
KW - lysine
KW - maize
N1 - Accession Number: 19030649; Azziz-Baumgartner, Eduardo 1; Email Address: eha9@cdc.gov; Lindblade, Kimberly 2; Gieseker, Karen 3; Rogers, Helen Schurz 1; Kieszak, Stephanie 1; Njapau, Henry 4; Schleicher, Rosemary 1; McCoy, Leslie F. 1; Misore, Ambrose 5; de Cook, Kevin 6; Rubin, Carol 1; Slutsker, Laurence 7; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 4: Food and Drug Administration, Washington, DC, USA; 5: Preventive and Promotive Health Services, Kenya Ministry of Health, Nairobi, Kenya; 6: Centers for Disease Control and Prevention, Kenya Field Office, Nairobi, Kenya; 7: Centers for Disease Control and Prevention, Kenya Field Office, Kisumu, Kenya; Issue Info: Dec2005, Vol. 113 Issue 12, p1779; Thesaurus Term: Aflatoxins; Thesaurus Term: Mycotoxins; Thesaurus Term: Epidemics; Thesaurus Term: Epidemiology; Subject Term: Mycotoxins -- Physiological effect; Subject Term: Microbial toxins; Subject Term: Fungal metabolites; Subject: Kenya; Author-Supplied Keyword: aflatoxicosis; Author-Supplied Keyword: aflatoxin; Author-Supplied Keyword: albumin adducts; Author-Supplied Keyword: lysine; Author-Supplied Keyword: maize; Number of Pages: 5p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1289/ehp.8384
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - Serial dilution with a confirmation step
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2005/12//
VL - 22
IS - 6
M3 - Article
SP - 547
EP - 552
SN - 07400020
AB - Abstract: A serial dilution test estimates the concentration of a microbe in a broth by inoculating several tubes with portions of the broth. The test may include both presumptive and confirmation steps. For the confirmation step considered here a portion of the contents of each tube indicating a change in the presumptive step is streaked on a plate. Several colonies are selected and examined to determine if the tube contained the target microbe. A statistical model accounts for the possibility of not selecting the target microbe from a tube that contains it and a similar appearing microbe. Simulations show that this model sometimes gives estimates similar to those currently used, but at other times can make large corrections. Also, a commonness measure helps check the validity of the assumptions of this statistical model. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DILUTION
KW - BACTERIA
KW - TUBES
KW - STRUCTURAL shells
KW - Microbial concentration
KW - Most probable number
KW - MPN
KW - Plating
KW - Selected colonies
N1 - Accession Number: 17695930; Blodgett, Robert J. 1; Email Address: rblodget@cfsan.fda.gov; Affiliation: 1: US Food and Drug Administration, Division of Mathematics, Center for Food Safety and Applied Nutrition, HFS-705, Rm 2D-011, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Source Info: Dec2005, Vol. 22 Issue 6, p547; Subject Term: DILUTION; Subject Term: BACTERIA; Subject Term: TUBES; Subject Term: STRUCTURAL shells; Author-Supplied Keyword: Microbial concentration; Author-Supplied Keyword: Most probable number; Author-Supplied Keyword: MPN; Author-Supplied Keyword: Plating; Author-Supplied Keyword: Selected colonies; NAICS/Industry Codes: 331210 Iron and Steel Pipe and Tube Manufacturing from Purchased Steel; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fm.2004.11.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dubois, Janie
AU - Neil Lewis, E.
AU - Fry, Frederick S.
AU - Calvey, Elizabeth M.
T1 - Bacterial identification by near-infrared chemical imaging of food-specific cards
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2005/12//
VL - 22
IS - 6
M3 - Article
SP - 577
EP - 583
SN - 07400020
AB - Abstract: Near-infrared chemical imaging (NIR-CI) is investigated as a tool for the high-throughput analysis of self-contained microbial identification test cards for micro-organisms of concern in food. In this initial work, a NIR-CI system operating in the spectral range 1000–2350nm was used to acquire NIR chemical images of bacterial cells deposited on a ‘card’, containing both the calibration and test samples. Results show that some bacteria can be identified from differences observed at unique wavelengths, and that a standard operating procedure can be developed for a particular ‘card’ to differentiate and hence identify the various organisms it contains using discrete wavelengths. For situations where a particular organism of concern is sought, a PLS chemometric model may offer better performance by accounting for variables that can be incorporated in the calibration without the need to know the taxonomic identity of the complete complement of bacteria present on the ‘card’. Overall, the NIR-CI results obtained in this investigation show that this high throughput technique possesses the specificity required to differentiate bacteria on the basis of their NIR spectra. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOOLS
KW - MICROORGANISMS
KW - COMPARISON (Psychology)
KW - SPECTRUM analysis
KW - Bacteria
KW - Food
KW - NIR imaging
N1 - Accession Number: 17695935; Dubois, Janie 1 Neil Lewis, E. 2 Fry, Frederick S. 3; Email Address: frederick.fry@cfsan.fda.gov Calvey, Elizabeth M. 3; Affiliation: 1: Joint Institute for Food Safety and Applied Nutrition (JIFSAN), Food and Drug Administration & University of Maryland College Park, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA 2: Spectral Dimensions, Inc., 3416 Olandwood Court, Suite 210, Olney, MD 20832, USA 3: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Dec2005, Vol. 22 Issue 6, p577; Subject Term: TOOLS; Subject Term: MICROORGANISMS; Subject Term: COMPARISON (Psychology); Subject Term: SPECTRUM analysis; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Food; Author-Supplied Keyword: NIR imaging; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 444130 Hardware Stores; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fm.2005.01.001
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ER -
TY - JOUR
AU - Salazar, Edith L.
AU - Paredes, Adrián
AU - Calzada, Leobardo
T1 - Endometrial thickness of postmenopausal breast cancer patients treatedwith tamoxifen.
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
Y1 - 2005/12//
VL - 21
IS - 6
M3 - Article
SP - 312
EP - 316
PB - Taylor & Francis Ltd
SN - 09513590
AB - The effect of administration time of tamoxifen was assessed in 52 postmenopausal patients with mammary cancer in order to evaluate its effect on endometrium and serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol. Mean age of the patients was 61.5 years, 23% had a history of smoking, mean body mass index (BMI) was 26.9 kg/m 2 , and mean age at menarche, menopause and administration time of tamoxifen was 12.9, 48 and 3.5 years, respectively. Serum FSH and LH concentrations were decreased by 41.8% and 44.9%, respectively, compared with mean normal postmenopausal levels. The FSH decrement was associated with BMI and LH level, whereas the LH decrement was associated with patient age and FSH concentration. Endometrium thickness [ABSTRACT FROM AUTHOR]
AB - Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAMOXIFEN
KW - BREAST cancer -- Patients
KW - MENOPAUSE
KW - ENDOMETRIUM
KW - THICKNESS measurement
KW - FOLLICLE-stimulating hormone
KW - LUTEINIZING hormone
KW - BODY mass index
KW - breast cancer
KW - Endometrium
KW - tamoxifen
N1 - Accession Number: 19302341; Salazar, Edith L. 1; Email Address: draedithsalazar@yahoo.com.mx Paredes, Adrián 2 Calzada, Leobardo 3; Affiliation: 1: Medical Research Unit in Endocrine Disease, Medical Research Coordination, Social Security Mexican Institute (IMSS), Mexico City, Mexico. 2: Clinic of Breast Disease, Gynecology and Obstetric Hospital No. 4 'Luis Castelazo Ayala', IMSS, Mexico City, Mexico. 3: Health Center (T-III) Dr Manuel Escontria, Sanitary Jurisdiction Alvaro Obregon, Public Health Service of Distrito Federal, Mexico City, Mexico.; Source Info: Dec2005, Vol. 21 Issue 6, p312; Subject Term: TAMOXIFEN; Subject Term: BREAST cancer -- Patients; Subject Term: MENOPAUSE; Subject Term: ENDOMETRIUM; Subject Term: THICKNESS measurement; Subject Term: FOLLICLE-stimulating hormone; Subject Term: LUTEINIZING hormone; Subject Term: BODY mass index; Author-Supplied Keyword: breast cancer; Author-Supplied Keyword: Endometrium; Author-Supplied Keyword: tamoxifen; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/09513590500430450
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DB - aph
ER -
TY - JOUR
AU - Bassen, H.
AU - Schaefer, D. J.
AU - Zaremba, L.
AU - Bushberg, J.
AU - Ziskin, M.
AU - Foster, K. R.
T1 - IEEE COMMITTEE ON MAN AND RADIATION (COMAR) TECHNICAL INFORMATION STATEMENT "EXPOSURE OF MEDICAL PERSONNEL TO ELECTROMAGNETIC FIELDS FROM OPEN MAGNETIC RESONANCE IMAGING SYSTEMS".
JO - Health Physics
JF - Health Physics
Y1 - 2005/12//
VL - 89
IS - 6
M3 - Article
SP - 684
EP - 689
SN - 00179078
AB - Open magnetic resonance imaging (MRI) systems enable performing image-guided medical procedures for long periods of time very close to, or inside, the patient imaging area. Medical personnel can be exposed to relatively high static, gradient, and radiofrequency fields compared to most other MRI systems. The Committee on Man and Radiation of the Institute of Electrical and Electronics Engineers calculated or used existing data on magnetic flux densities and field strengths in or near the patient area to assess occupational exposure levels. Potential exposures to each field type were analyzed and compared to relevant values specified in international exposure limits including those of the Institute of Electrical and Electronics Engineers and the International Commission on Nonionizing Radiation Protection. Exposures of the head or torso of a worker to gradient fields near the center of the patient-imaging area can exceed most exposure limits even for times less than a second. Exposures to radiofrequency fields can exceed limits if sustained exposures (minutes or more) occur to parts of the body. Static magnetic fields used by present Open MRI systems are below exposure limits of all of the standards that address these fields. Overall results of this study suggest that manufacturers and others who program or operate Open MRI systems should take care to ensure that operating parameters produce exposures that comply with the relevant exposure limits. Also, since field levels fall off rapidly with increasing distance, user practices may be implemented that reduce exposures significantly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Physics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnetic resonance imaging
KW - Medical personnel
KW - Electromagnetic fields
KW - Diagnostic imaging
KW - Associations, institutions, etc.
KW - Radio frequency
KW - exposure
KW - magnetic fields
KW - magnetic resonance imaging
KW - radiofrequency
KW - safety standards
N1 - Accession Number: 19024156; Bassen, H. 1; Email Address: hib@cdrh.fda.gov; Schaefer, D. J. 2; Zaremba, L. 1; Bushberg, J. 3; Ziskin, M. 4; Foster, K. R. 5; Affiliations: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, 12725 Twinbrook Parkway, Rockville, MD 20852.; 2: GE Medical Systems.; 3: University of California, Davis.; 4: Temple University.; 5: University of Pennsylvania.; Issue Info: Dec2005, Vol. 89 Issue 6, p684; Subject Term: Magnetic resonance imaging; Subject Term: Medical personnel; Subject Term: Electromagnetic fields; Subject Term: Diagnostic imaging; Subject Term: Associations, institutions, etc.; Subject Term: Radio frequency; Author-Supplied Keyword: exposure; Author-Supplied Keyword: magnetic fields; Author-Supplied Keyword: magnetic resonance imaging; Author-Supplied Keyword: radiofrequency; Author-Supplied Keyword: safety standards; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jackson, N.
AU - Waters, E.
AU - Anderson, L.
AU - Bailie, R.
AU - G. Brunton
AU - P. Hawe
AU - E. Kristjansson
AU - L. Naccarella
AU - S. Norris
AU - S. Oliver
AU - M. Petticrew
AU - E. Pienaar
AU - J. Popay
AU - H. Roberts
AU - W. Rogers
AU - J. Shepherd
AU - A. Sowden
AU - H. Thomas
T1 - Criteria for the systematic review of health promotion and public health interventions.
JO - Health Promotion International
JF - Health Promotion International
Y1 - 2005/12//
VL - 20
IS - 4
M3 - Article
SP - 367
EP - 374
SN - 09574824
AB - Systematic reviews of public health interventions are fraught with challenges. Complexity is inherent; this may be due to multi-component interventions, diverse study populations, multiple outcomes measured mixed study designs utilized and the effect of context on intervention design, implementation and effectiveness. For policy makers and practitioners to use systematic reviews to implement effective public health programmes, systematic reviews must include this information, which seeks to answer the questions posed by decision makers, including recipients of programmes. This necessitates expanding the traditional evaluation of evidence to incorporate the assessment of theory, integrity of interventions, context and sustainability of the interventions and outcomes. Unfortunately however, the critical information required for judging both the quality of a public health intervention and whether or not an intervention is worthwhile or replicable is missing from most public health intervention studies. When the raw material is not available in primary studies the systematic review process becomes even more challenging. Systematic reviews, which highlight these critical gaps, may act to encourage better reporting in primary studies. This paper provides recommendations to reviewers on the issues to address within a public health systematic review and, indirectly, provides advice to researchers on the reporting requirements of primary studies for the production of high quality systematic reviews. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Promotion International is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - HEALTH care intervention (Social services)
KW - PUBLIC health
KW - SYSTEMATIC reviews (Medical research)
KW - PREVENTIVE health services
KW - effectiveness
KW - Public Health intervention
KW - review
KW - systematic
N1 - Accession Number: 25637655; Jackson, N. 1 Waters, E. 2 Anderson, L. 3 Bailie, R. 4 G. Brunton 5 P. Hawe 6 E. Kristjansson 7 L. Naccarella 8 S. Norris 9 S. Oliver 10 M. Petticrew 11 E. Pienaar 12 J. Popay 13 H. Roberts 14 W. Rogers 15 J. Shepherd 16 A. Sowden 17 H. Thomas 18; Affiliation: 1: Cochrane Health Promotion and Public Health Field, Australia 2: School of Health & Social Development, Deakin University, Australia 3: Centers for Disease Control and Prevention, USA 4: Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Australia 5: Evidence for Policy and Practice Information and Co-ordinating (EPPI) Centre, Institute of Education, University of London, UK 6: University of Calgary, Canada 7: University of Ottawa, Canada 8: University of Melbourne, Australia 9: Agency for Healthcare Research and Quality, USA 10: EPPI-Centre, Institute of Education, University of London, UK 11: MRC Social and Public Health Sciences Unit, UK 12: South African Cochrane Centre 13: Lancaster University, UK 14: City University, UK 15: Flinders University, Australia 16: University of Southampton, UK 17: Centre for Reviews and Dissemination, University of York, UK 18: McMaster University and the Effective Public Health Practice Project, Canada; Source Info: Dec2005, Vol. 20 Issue 4, p367; Subject Term: HEALTH promotion; Subject Term: HEALTH care intervention (Social services); Subject Term: PUBLIC health; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: PREVENTIVE health services; Author-Supplied Keyword: effectiveness; Author-Supplied Keyword: Public Health intervention; Author-Supplied Keyword: review; Author-Supplied Keyword: systematic; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
L3 - 10.1093/heapro/dai022
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Miller, G. Edward
AU - Moeller, John F.
AU - Stafford, Randall S.
T1 - New Cardiovascular Drugs: Patterns of Use and Association with Non-Drug Health Expenditures.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2005///Winter2005/2006
VL - 42
IS - 4
M3 - Abstract
SP - 397
EP - 412
SN - 00469580
AB - The potential role of new drugs in reducing expenditures for non-drug health services has received considerable attention in recent policy debates. We estimate expenditure models to determine whether the use of newer drugs to treat cardiovascular conditions is associated with lower (or higher) non-drug expenditures for these conditions. We fail to substantiate the findings of previous research that newer drugs are associated with reductions in non-drug expenditures. We find, however, that increases in the number of drugs used, or the mix of drugs of different ages, are associated with increased non-drug expenditures and find that the number or mix of drugs used are important confounders in the estimated association between drug age and non-drug expenditures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOVASCULAR agents
KW - DRUG utilization
KW - THERAPEUTICS
KW - MEDICAL care costs
KW - CARDIOVASCULAR diseases
KW - UNITED States
N1 - Accession Number: 20448180; Miller, G. Edward 1,2; Email Address: emiller@ahrq.gov; Moeller, John F. 3; Stafford, Randall S. 4; Affiliations: 1: Economist, Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ); 2: Professor, Department of Health Promotion and Policy, University of Maryland Dental School; 3: Associate Professor, Medicine, Stanford Prevention Research Center, Stanford University; 4: Director, Program on Prevention, Stanford Prevention Research Center, Stanford University; Issue Info: Winter2005/2006, Vol. 42 Issue 4, p397; Subject Term: CARDIOVASCULAR agents; Subject Term: DRUG utilization; Subject Term: THERAPEUTICS; Subject Term: MEDICAL care costs; Subject Term: CARDIOVASCULAR diseases; Subject: UNITED States; Number of Pages: 6p; Illustrations: 4 Charts, 5 Graphs; Document Type: Abstract
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106343548
T1 - New cardiovascular drugs: patterns of use and association with non-drug health expenditures.
AU - Miller GE
AU - Moeller JF
AU - Stafford RS
Y1 - 2005///Winter2005/2006
N1 - Accession Number: 106343548. Language: English. Entry Date: 20061006. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Supplement Title: Winter2005/2006. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Cardiovascular Agents -- Economics
KW - Cost Control
KW - Health Care Costs -- Trends
KW - Adult
KW - Aged
KW - Comparative Studies
KW - Descriptive Statistics
KW - Drug Approval
KW - Female
KW - Male
KW - Middle Age
KW - Pearson's Correlation Coefficient
KW - Sample Size
KW - T-Tests
KW - United States
KW - Human
SP - 397
EP - 412
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 42
IS - 4
PB - Sage Publications Inc.
AB - The potential role of new drugs in reducing expenditures for non-drug health services has received considerable attention in recent policy debates. We estimate expenditure models to determine whether the use of newer drugs to treat cardiovascular conditions is associated with lower (or higher) non-drug expenditures for these conditions. We fail to substantiate the findings of previous research that newer drugs are associated with reductions in non-drug expenditures. We find, however, that increases in the number of drugs used, or the mix of drugs of different ages, are associated with increased non-drug expenditures and find that the number or mix of drugs used are important confounders in the estimated association between drug age and non-drug expenditures.
SN - 0046-9580
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; emiller@ahrq.gov
U2 - PMID: 16568931.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lyons, Ronan A.
AU - Brophy, Sinead
AU - Pockett, Rhys
AU - John, Gareth
T1 - Purpose, development and use of injury indicators.
JO - International Journal of Injury Control & Safety Promotion
JF - International Journal of Injury Control & Safety Promotion
Y1 - 2005/12//
VL - 12
IS - 4
M3 - Article
SP - 207
EP - 211
PB - Taylor & Francis Ltd
SN - 17457300
AB - Injury indicators can be used to give policy makers an estimate of the scale of injuries and their long term effects. They can help compare injury levels in different areas and countries and can be used to help measure the effectiveness of interventions. Work on severity related indicators is promising. However there are no perfect indicators to date as many are hampered with difficulties in case definition and under reporting. For example, mortality rates are affected by improvements in care even if the incidence of an injury remains the same, the abbreviated injury scale (AIS) takes 10-20 minutes to code and so is not used in health service databases, surveys have problems with recall bias, definition of injury and response rates. If we accept that we need to make the best out of imperfect indicators and imperfect data then we should use multiple sources of data and accept that no one indicator can be used universally but needs to be selected for the purpose. For example, one possible new indicator of the incidence of non-fatal injury might be fracture data in the emergency department. Fractures are painful and so nearly always end up with a hospital attendance. This might give a means to compare incidence of non-fatal injury in different areas and countries. In conclusion, we need injury indicators to progress in injury prevention. Imperfect indicators can be used for targeting and evaluating interventions as long as we know and adjust for their limitations. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Injury Control & Safety Promotion is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical emergencies
KW - Wounds & injuries -- Diagnosis
KW - Accident prevention
KW - Mortality
KW - Emergency medical services
KW - Hospital emergency services
KW - Burden of injury
KW - Injury index
KW - Injury indicators
N1 - Accession Number: 19457489; Lyons, Ronan A. 1; Email Address: r.a.lyons@swansea.ac.uk; Brophy, Sinead 1; Pockett, Rhys 2; John, Gareth 3; Affiliations: 1: School of Medicine, University of Wales Swansea, Grove Building, Singleton Park, Swansea SA2 8PP, UK.; 2: National Public Health Service for Wales, Cardiff, UK.; 3: Health Solutions Wales, Cardiff, UK.; Issue Info: Dec2005, Vol. 12 Issue 4, p207; Subject Term: Medical emergencies; Subject Term: Wounds & injuries -- Diagnosis; Subject Term: Accident prevention; Subject Term: Mortality; Subject Term: Emergency medical services; Subject Term: Hospital emergency services; Author-Supplied Keyword: Burden of injury; Author-Supplied Keyword: Injury index; Author-Supplied Keyword: Injury indicators; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/17457300500172776
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gary, Faye A.
T1 - FROM THE GUEST EDITOR—RESEARCH ON THE STIGMA OF MENTAL ILLNESS AMONG ETHNIC MINORITY POPULATIONS IN THE UNITED STATES.
JO - Issues in Mental Health Nursing
JF - Issues in Mental Health Nursing
Y1 - 2005/12//
VL - 26
IS - 10
M3 - Article
SP - 971
EP - 977
SN - 01612840
AB - The article introduces papers on the stigma of mental illness among ethnic minority populations in the United States, published in the December 2005 issue of the periodical "Mental Health Nursing."
KW - MENTAL illness
KW - MINORITIES
N1 - Accession Number: 18807154; Gary, Faye A. 1; Affiliation: 1: Substance Abuse and Mental Health Services Administration, Minority Fellowship Program, American Nurses Association, Executive Consultant and Medical Mutual of Ohio Professor of Nursing for Vulnerable and At-Risk Persons, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio; Source Info: Dec2005, Vol. 26 Issue 10, p971; Subject Term: MENTAL illness; Subject Term: MINORITIES; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/01612840500280588
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hendricks, Kitty J.
AU - Layne, Larry A.
AU - Goldcamp, E. Michael
AU - Myers, John R.
T1 - Injuries to Youth Living on U.S. Farms in 2001 with Comparison to 1998.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2005/12//
VL - 10
IS - 4
M3 - Article
SP - 19
EP - 26
SN - 1059924X
AB - To obtain sustained injury surveillance data for youth on farms, the National Institute for Occupational Safety and Health developed the Childhood Agricultural Injury Survey (CAIS) in collaboration with the U.S. Department of Agriculture. The first CAIS collected data for youth less than 20 years in 1998 through a regionally stratified telephone survey of 50,000 U.S. farm households; a second CAIS for 2001 was conducted using the same methodology. In 2001, there were approximately 1.2 million youth living on U.S. farms. These youth suffered an estimated 19,397 injuries (15.7/1,000 household youth). Approximately 60% (11,571) of the household youth injuries were to males. For all household youth, 10–15 year olds experienced the most injuries (49%, 9,486). In addition to providing estimates of demographics, injuries, and injury rates for household youth from the 2001 CAIS, this article provides a comparison to results from the 1998 CAIS. The number of household youth injuries on farms from 1998 to 2001 decreased by almost 30% (27,321 vs. 19,397). The results of this study show an overall decrease in the injury rate for youth living on the farm from 1998 to 2001 (18.8/1,000 household youth vs. 15.7/1,000 household youth). However, there was a considerable increase in the number of injuries to household females less than 20 years of age during this same time period. There was also an increase in the number of all terrain vehicle (ATV) and horse-related injuries. Continued surveillance is needed to assess if these are significant trends or the result of changing farm demographics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YOUTH
KW - WOUNDS & injuries
KW - TELEPHONE surveys
KW - AGRICULTURAL safety
KW - FARMS
KW - PUBLIC health
KW - CHILDREN'S accidents
KW - UNITED States
KW - Farm injuries
KW - surveillance
KW - youth
KW - UNITED States. Dept. of Agriculture
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 21745338; Hendricks, Kitty J. 1; Email Address: khendricks@cdc.gov Layne, Larry A. 1 Goldcamp, E. Michael 1 Myers, John R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, 1095 Willowdale Road, M/S 1808, Morgantown, WV 26505; Source Info: 2005, Vol. 10 Issue 4, p19; Subject Term: YOUTH; Subject Term: WOUNDS & injuries; Subject Term: TELEPHONE surveys; Subject Term: AGRICULTURAL safety; Subject Term: FARMS; Subject Term: PUBLIC health; Subject Term: CHILDREN'S accidents; Subject Term: UNITED States; Author-Supplied Keyword: Farm injuries; Author-Supplied Keyword: surveillance; Author-Supplied Keyword: youth; Company/Entity: UNITED States. Dept. of Agriculture Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1300/J096v10n0405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21745338&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106262547
T1 - Injuries to youth living on U.S. farms in 2001 with comparison to 1998.
AU - Hendricks KJ
AU - Layne LA
AU - Goldcamp EM
AU - Myers JR
Y1 - 2005/12//
N1 - Accession Number: 106262547. Language: English. Entry Date: 20070406. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Lee BC. NIOSH fills void with surveillance of injuries to youth living on U.S. farms. (J AGROMED) 2005; 10 (4): 3-4. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Agriculture
KW - Occupational Exposure -- Adverse Effects
KW - Occupational-Related Injuries -- Epidemiology
KW - Accidents, Occupational
KW - Confidence Intervals
KW - Data Analysis Software
KW - Epidemiological Research
KW - Stratified Random Sample
KW - Surveys
KW - Human
SP - 19
EP - 26
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 10
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - To obtain sustained injury surveillance data for youth on farms, the National Institute for Occupational Safety and Health developed the Childhood Agricultural Injury Survey (CAIS) in collaboration with the U.S. Department of Agriculture. The first CAIS collected data for youth less than 20 years in 1998 through a regionally stratified telephone survey of 50,000 U.S. farm households; a second CAIS for 2001 was conducted using the same methodology. In 2001, there were approximately 1.2 million youth living on U.S. farms. These youth suffered an estimated 19,397 injuries (15.7/1,000 household youth). Approximately 60% (11,571) of the household youth injuries were to males. For all household youth, 10-15 year olds experienced the most injuries (49%, 9,486). In addition to providing estimates of demographics, injuries, and injury rates for household youth from the 2001 CAIS, this article provides a comparison to results from the 1998 CAIS. The number of household youth injuries on farms from 1998 to 2001 decreased by almost 30% (27,321 vs. 19,397). The results of this study show an overall decrease in the injury rate for youth living on the farm from 1998 to 2001 (18.8/1,000 household youth vs. 15.7/1,000 household youth). However, there was a considerable increase in the number of injuries to household females less than 20 years of age during this same time period. There was also an increase in the number of all terrain vehicle (ATV) and horse-related injuries. Continued surveillance is needed to assess if these are significant trends or the result of changing farm demographics.
SN - 1059-924X
AD - Division of Safety Research, Surveillance and Field Investigations Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA. khendricks@cdc.gov
U2 - PMID: 16702120.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106319247
T1 - Individual self-reported items are not accurate markers for a history of chronic periodontitis.
AU - Tomar S
Y1 - 2005/12//
N1 - Accession Number: 106319247. Language: English. Entry Date: 20060818. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Original Study: Dietrich T, Stosch U, Dietrich D, Schamberger D, Bernimoulin J, Joshipura K. The accuracy of individual self-reported items to determine periodontal disease history. (EUR J ORAL SCI) Apr2005; 113 (2): 135-140. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101083101.
KW - Periodontitis
KW - Self Report
KW - Germany
SP - 219
EP - 221
JO - Journal of Evidence-Based Dental Practice
JF - Journal of Evidence-Based Dental Practice
JA - J EVID BASED DENT PRACT
VL - 5
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1532-3382
AD - University of Florida, Division of Public Health Service & Research, Gainesville, FL
U2 - PMID: 17138380.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Koonse, Brett
AU - Burkhardt III, William
AU - Chirtel, Stuart
AU - Hoskin, George P.
T1 - Salmonella and the Sanitary Quality of Aquacultured Shrimp.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/12//
VL - 68
IS - 12
M3 - Article
SP - 2527
EP - 2532
SN - 0362028X
AB - In this study, we examined the prevalence of Salmonella and coliform bacteria on shrimp aquaculture farms to develop guidelines or preventative measures for reducing Salmonella and fecal contamination on products harvested from these farms. The U.S. Food and Drug Administration, in conjunction with foreign government regulatory agencies, the aquaculture industry, and academia affiliates, analyzed 1,234 samples from 103 shrimp aquaculture farms representing six countries between July 2001 and June 2003 for fecal coliforms, Escherichia coli, and Salmonella. A significant relationship was found (P = 0.0342) between the log number of fecal bacteria and the probability that any given sample would contain Salmonella. The likelihood of any given sample containing Salmonella was increased by 1.2 times with each 10-fold increase in either fecal coliform or E. coli concentration. The statistical relationship between Salmonella concentration and that of both fecal coliforms and K coli was highest in grow-out pond water (P = 0.0042 for fecal coliforms and P = 0.002 1 for E. coli). The likelihood of finding Salmonella in grow-out pond water increased 2.7 times with each log unit increase in fecal coliform concentration and 3.0 times with each log unit increase in E. coli concentration. Salmonella is not part of the natural flora of the shrimp culture environment nor is it inherently present in shrimp grow-out ponds. The occurrence of Salmonella bacteria in shrimp from aquaculture operations is related to the concentration of fecal bacteria in the source and grow-out pond water. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Aquaculture
KW - Escherichia coli
KW - Microbial contamination
KW - Ponds
KW - Shrimp culture
KW - Fecal microbiology
KW - United States
N1 - Accession Number: 19195233; Koonse, Brett 1; Email Address: brett.koonse@fda.gov; Burkhardt III, William 2; Chirtel, Stuart 3; Hoskin, George P. 1; Affiliations: 1: Office of Seafood, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland 20740, USA; 2: Office of Seafood, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528, USA; 3: Division of Mathematics, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland 20740, USA; Issue Info: Dec2005, Vol. 68 Issue 12, p2527; Thesaurus Term: Salmonella; Thesaurus Term: Aquaculture; Thesaurus Term: Escherichia coli; Thesaurus Term: Microbial contamination; Thesaurus Term: Ponds; Subject Term: Shrimp culture; Subject Term: Fecal microbiology; Subject: United States; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yancy, Haile F.
AU - Mohla, Anuja
AU - Farrell, Dorothy E.
AU - Myers, Michael J.
T1 - Evaluation of a Rapid PCR-Based Method for the Detection of Animal Material.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/12//
VL - 68
IS - 12
M3 - Article
SP - 2651
EP - 2655
SN - 0362028X
AB - Performance characteristics were evaluated for two lateral-flow test kits, Reveal for Ruminant in Feed (Neogen Corporation) and FeedChek (Strategic Diagnostics Inc.), designed to detect ruminant or terrestrial animal proteins in feeds. The stringent acceptance criteria used were developed by the Center for Veterinary Medicine Office of Research to identify test kits with comparable selectivity and sensitivity to microscopy and PCR assay, the analytical methods used by the U.S. Food and Drug Administration (FDA). Guidelines were developed for evaluating the selectivity, sensitivity, ruggedness, and specificity of these kits. These guidelines further stated that ruggedness and specificity testing would be performed only after a test passed both the selectivity and sensitivity assessments. Acceptance criteria for determining success were developed using a statistical approach requiring 90% probability of achieving the correct response, within a 95% confidence interval. A minimum detection level of 0.1% bovine meat and bone meal, consistent with the sensitivity of the methods used by the FDA, was required. Selectivity was assessed by testing 60 dairy feed samples that contained no added animal proteins; sensitivity was determined by evaluating 60 samples (per level of fortification) of the same feed that contained 0.025, 0.05, 0.1, 0.25, 0.5, 1, or 2% bovine meat and bone meal. The Reveal test passed the selectivity assessment but failed the sensitivity assessment, detecting only samples fortified at the 2% level and then only 17 to 33% of those samples, when read according to the label directions. The FeedChek test passed the sensitivity assessment but failed the selectivity assessment, with rates for false- positive results ranging from 34 to 38%, depending on the user. The sensitivity of the Reveal test was affected by the concentration of trace minerals present in the feed; concentrations toward the high end of the normal range prevented the detection of true positive feed samples containing bovine meat and bone meal. Better sensitivity assessments were obtained when lamb meal was used either alone or in combination with bovine meat and bone meal. The FeedChek test was not affected by the concentration of trace minerals or by the type of animal meal used. These results indicate that neither of the two tests is adequate for routine regulatory use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Feeds
KW - Chemical tests & reagents
KW - Ruminants
KW - Meat
KW - Polymerase chain reaction
KW - Microscopy
KW - Animal products as feed
KW - United States. Food & Drug Administration
N1 - Accession Number: 19195249; Yancy, Haile F. 1; Mohla, Anuja 1; Farrell, Dorothy E. 1; Myers, Michael J. 1; Email Address: mmyers@cvm.fda.gov; Affiliations: 1: Division of Animal Research, U.S. Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, Maryland 20708, USA; Issue Info: Dec2005, Vol. 68 Issue 12, p2651; Thesaurus Term: Feeds; Thesaurus Term: Chemical tests & reagents; Thesaurus Term: Ruminants; Thesaurus Term: Meat; Subject Term: Polymerase chain reaction; Subject Term: Microscopy; Subject Term: Animal products as feed ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; Number of Pages: 5p; Illustrations: 2 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Myers, Michael J.
AU - Yancy, Haile F.
AU - Farrell, Dorothy E.
AU - Washington, Jewell D.
AU - Frobish, Russell A.
T1 - Evaluation of Two Commercial Lateral-Flow Test Kits for Detection of Animal Proteins in Animal Feed.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2005/12//
VL - 68
IS - 12
M3 - Article
SP - 2656
EP - 2664
SN - 0362028X
AB - Performance characteristics were evaluated for two lateral-flow test kits, Reveal for Ruminant in Feed (Neogen Corporation) and FeedChek (Strategic Diagnostics Inc.), designed to detect ruminant or terrestrial animal proteins in feeds. The stringent acceptance criteria used were developed by the Center for Veterinary Medicine Office of Research to identify test kits with comparable selectivity and sensitivity to microscopy and PCR assay, the analytical methods used by the U.S. Food and Drug Administration (FDA). Guidelines were developed for evaluating the selectivity, sensitivity, ruggedness, and specificity of these kits. These guidelines further stated that ruggedness and specificity testing would be performed only after a test passed both the selectivity and sensitivity assessments. Acceptance criteria for determining success were developed using a statistical approach requiring 90% probability of achieving the correct response, within a 95% confidence interval. A minimum detection level of 0.1% bovine meat and bone meal, consistent with the sensitivity of the methods used by the FDA, was required. Selectivity was assessed by testing 60 dairy feed samples that contained no added animal proteins; sensitivity was determined by evaluating 60 samples (per level of fortification) of the same feed that contained 0.025, 0.05, 0.1, 0.25, 0.5, 1, or 2% bovine meat and bone meal. The Reveal test passed the selectivity assessment but failed the sensitivity assessment, detecting only samples fortified at the 2% level and then only 17 to 33% of those samples, when read according to the label directions. The FeedChek test passed the sensitivity assessment but failed the selectivity assessment, with rates for false- positive results ranging from 34 to 38%, depending on the user. The sensitivity of the Reveal test was affected by the concentration of trace minerals present in the feed; concentrations toward the high end of the normal range prevented the detection of true positive feed samples containing bovine meat and bone meal. Better sensitivity assessments were obtained when lamb meal was used either alone or in combination with bovine meat and bone meal. The FeedChek test was not affected by the concentration of trace minerals or by the type of animal meal used. These results indicate that neither of the two tests is adequate for routine regulatory use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemical tests & reagents
KW - Ruminants
KW - Meat
KW - Feeds -- Analysis
KW - Polymerase chain reaction
KW - Microscopy
KW - Animal products as feed
KW - United States. Food & Drug Administration
N1 - Accession Number: 19195250; Myers, Michael J. 1; Email Address: mmyers@cvm.fda.gov; Yancy, Haile F. 1; Farrell, Dorothy E. 1; Washington, Jewell D. 1; Frobish, Russell A. 1; Affiliations: 1: Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA; Issue Info: Dec2005, Vol. 68 Issue 12, p2656; Thesaurus Term: Chemical tests & reagents; Thesaurus Term: Ruminants; Thesaurus Term: Meat; Subject Term: Feeds -- Analysis; Subject Term: Polymerase chain reaction; Subject Term: Microscopy; Subject Term: Animal products as feed ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; Number of Pages: 9p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tang, Xing
AU - Morris, Sheldon L.
AU - Langone, John J.
AU - Bockstahler, Larry E.
T1 - Microarray and allele specific PCR detection of point mutations in Mycobacterium tuberculosis genes associated with drug resistance
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2005/12//
VL - 63
IS - 3
M3 - Article
SP - 318
EP - 330
SN - 01677012
AB - Abstract: Global public health is threatened by the emergence of potentially dangerous antibiotic drug-resistant strains of Mycobacterium tuberculosis. Point mutations in certain M. tuberculosis genes are associated with the resistance of M. tuberculosis strains to antibiotic drugs. The purpose of this study was to develop a suitable microarray-based protocol for the detection of point mutations in M. tuberculosis genes associated with drug resistance. We initially developed a conventional, oligonucleotide microarray protocol and used it to detect and identify on a single microarray slide a number of point mutation-containing rpoB and katG gene target sequences. However, the occurrence of some non-specific hybridization led us to the development of an improved protocol based on allele specific PCR combined with tags/anti-tags and microarrays. This protocol was evaluated by detecting point mutations in M. tuberculosis katG and rpoB gene templates produced by recombinant PCR. The methodology allowed sequences containing single point mutations to be readily distinguished from wild type sequences. The data obtained with the improved protocol had strong and specific signals and relatively low amounts of non-specific hybridization. We successfully used this protocol to detect and identify (<8 h) a number of clinically relevant point mutations in the rpoB, katG and rpsL genes of M. tuberculosis clinical isolates. Our allele specific PCR/tags and anti-tags/microarray protocol has several advantages over our conventional oligonucleotide microarray protocol, and it may have broad applications for point mutation detection. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM tuberculosis
KW - POLYMERASE chain reaction
KW - MUTATION (Biology)
KW - DRUG resistance in microorganisms
KW - Allele specific PCR
KW - Drug resistance
KW - Microarray
KW - Mutants
KW - Mutation
KW - Mycobacterium tuberculosis
KW - PCR
KW - Point mutation
KW - Point mutation detection
N1 - Accession Number: 19010243; Tang, Xing 1; Email Address: xxt4@cdrh.fda.gov Morris, Sheldon L. 2 Langone, John J. 1 Bockstahler, Larry E. 1; Affiliation: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20850, United States 2: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, United States; Source Info: Dec2005, Vol. 63 Issue 3, p318; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: POLYMERASE chain reaction; Subject Term: MUTATION (Biology); Subject Term: DRUG resistance in microorganisms; Author-Supplied Keyword: Allele specific PCR; Author-Supplied Keyword: Drug resistance; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Mutants; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: Mycobacterium tuberculosis; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Point mutation; Author-Supplied Keyword: Point mutation detection; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.mimet.2005.04.026
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106391062
T1 - The effect of subject characteristics and respirator features on respirator fit.
AU - Zhuang Z
AU - Coffey CC
AU - Ann RB
Y1 - 2005/12//
N1 - Accession Number: 106391062. Language: English. Entry Date: 20060203. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Evaluation
KW - Analysis of Variance
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Female
KW - Male
KW - Pearson's Correlation Coefficient
KW - Simulations
KW - T-Tests
KW - Human
SP - 641
EP - 3
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 2
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A recent study was conducted to compare five fit test methods for screening out poor-fitting N95 filtering-facepiece respirators. Eighteen models of NIOSH-certified, N95 filtering-facepiece respirators were used to assess the fit test methods by using a simulated workplace protection factor (SWPF) test. The purpose of this companion study was to investigate the effect of subject characteristics (gender and face dimensions) and respirator features on respirator fit. The respirator features studied were design style (folding and cup style) and number of sizes available (one size fits all, two sizes, and three sizes). Thirty-three subjects participated in this study. Each was measured for 12 face dimensions using traditional calipers and tape. From this group, 25 subjects with face size categories 1 to 10 tested each respirator. The SWPF test protocol entailed using the PortaCount Plus to determine a SWPF based on total penetration (face-seal leakage plus filter penetration) while the subject performed six simulated workplace movements. Six tests were conducted for each subject/respirator model combination with redonning between tests. The respirator design style (folding style and cup style) did not have a significant effect on respirator fit in this study. The number of respirator sizes available for a model had significant impact on respirator fit on the panel for cup-style respirators with one and two sizes available. There was no significant difference in the geometric mean fit factor between male and female subjects for 16 of the 18 respirator models. Subsets of one to six face dimensions were found to be significantly correlated with SWPFs (p < 0.05) in 16 of the 33 respirator model/respirator size combinations. Bigonial breadth, face width, face length, and nose protrusion appeared the most in subsets (five or six) of face dimensions and their multiple linear regression coefficients were significantly different from zero (p < 0.05). Lip length was found in only one subset. The use of face length and lip length as the criteria to define the current half-facepiece respirator fit test panel may need to be reconsidered when revising the panel. Based on the findings from this and previous studies, face length and face width are recommended measurements that should be used for defining the panel for half-facepiece respirators.
SN - 1545-9624
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, PO Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236; zaz3@cdc.gov
U2 - PMID: 16298949.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109848977
T1 - Signs of national improvement in patient safety.
AU - McNeill D
AU - Moy E
AU - Clancy CM
Y1 - 2005/12//2005 Dec
N1 - Accession Number: 109848977. Language: English. Entry Date: 20080425. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Institute of Medicine (U.S.)
KW - Patient Safety
KW - Reports
KW - United States Agency for Healthcare Research and Quality
KW - Clinical Indicators
KW - Databases
KW - Goal Attainment
KW - Program Implementation
KW - Quality Improvement
KW - Quality of Health Care
SP - 179
EP - 180
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 1
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, Rockville, MD 20850
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Aurran-Schleinitz, T.
AU - Telford, W.
AU - Perfetto, S.
AU - Caporaso, N.
AU - Wilson, W.
AU - Stetler-Stevenson, M.A.
AU - Zenger, V.E.
AU - Abbasi, F.
AU - Marti, G.E.
T1 - Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia.
JO - Leukemia (08876924)
JF - Leukemia (08876924)
Y1 - 2005/12//
VL - 19
IS - 12
M3 - Letter
SP - 2339
EP - 2341
PB - Nature Publishing Group
SN - 08876924
AB - The article presents a letter to the editor about a study on oncogenic and cellular characterization of chronic lymphocytic leukemia.
KW - CHRONIC diseases
KW - CHRONIC lymphocytic leukemia
N1 - Accession Number: 18943388; Aurran-Schleinitz, T. 1,2 Telford, W. 3 Perfetto, S. 4 Caporaso, N. 5 Wilson, W. 6 Stetler-Stevenson, M.A. 7 Zenger, V.E. 2 Abbasi, F. 2 Marti, G.E. 2; Email Address: gemarti@helix.nih.gov; Affiliation: 1: Institut Paoli-Calmettes, Marseille, France 2: Division of Cell and Gene Therapies, Office of Cellular, Tissues and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 3: Flow Cytometry Core Facility, ETIB, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 4: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA 5: Genetics Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 6: MOCRU, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 7: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Source Info: Dec2005, Vol. 19 Issue 12, p2339; Subject Term: CHRONIC diseases; Subject Term: CHRONIC lymphocytic leukemia; Number of Pages: 3p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Letter
L3 - 10.1038/sj.leu.2403980
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McAvin, James C.
AU - Escamilla, Elizabeth M.
AU - Blow, Jamie A.
AU - Turell, Michael J.
AU - Quintana, Miguel
AU - Bowles, David E.
AU - Swaby, James A.
AU - Barnes, William J.
AU - Huff, William B.
AU - Lohman, Kenton L.
AU - Atchley, Daniel H.
AU - Hickman, John R.
AU - Niemeyer, Debra M.
T1 - Rapid Identification of Dengue Virus by Reverse Transcription-Polymerase Chain Reaction Using Field-Deployable Instrumentation.
JO - Military Medicine
JF - Military Medicine
Y1 - 2005/12//
VL - 170
IS - 12
M3 - Article
SP - 1053
EP - 1059
PB - AMSUS
SN - 00264075
AB - Dengue virus universal and dengue serotype 1 to 4, fluorogenic probe hydrolysis (TaqMan), reverse transcription-polymerase chain reaction assays were developed for screening and serotype identification of infected mosquito vectors and human sera using a field-deployable, fluorometric thermocycler. Dengue universal and dengue 1 to 4 serotype assay in vitro sensitivity and specificity results were 100% concordant when tested with total nucleic acid extracts of multiple strains of dengue serotype 1 to 4, yellow fever, Japanese encephalitis, West Nile, and St. Louis encephalitis viruses. The in vitro sensitivity and specificity results for all five assays were concordant when tested with a blind panel of 27 dengue virus-infected mosquitoes, 21 non-dengue (yellow fever, West Nile, or St. Louis encephalitis) flavivirus-infected mosquitoes, and 11 uninfected mosquitoes and with clinical specimens consisting of a human serum panel of eight dengue viremic and 31 non-dengue-infected febrile patient serum samples. No cross-reaction occurred with vector species or human genomic DNA. Sample processing and polymerase chain reaction required < 2 hours. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - DENGUE
KW - FLAVIVIRUSES
KW - POLYMERASE chain reaction
KW - MOSQUITOES as carriers of disease
N1 - Accession Number: 19287010; McAvin, James C. 1 Escamilla, Elizabeth M. 1 Blow, Jamie A. 2 Turell, Michael J. 2 Quintana, Miguel 3 Bowles, David E. 4 Swaby, James A. 4 Barnes, William J. 1 Huff, William B. 1 Lohman, Kenton L. 1 Atchley, Daniel H. 1 Hickman, John R. 1 Niemeyer, Debra M. 5,6; Affiliation: 1: Epidemiological Surveillance Division, Air Force Institute for Operational Health, Brooks City- Base), San Antonio, TX 78235-5237 2: Virology Division, U.S. Army Medical Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702-5011 3: Environmental Science Division, U.S. Army Center for Health Promotion and Preventative Medicine-West, Fort Lewis, WA 98433-9500 4: U.S. Air Force Force Protection Battlelab, Lackland Air Force Base, San Antonio, TX 78236-0119 5: U.S. Air Force Office of the Surgeon General, Bolling Air Force Base, Washington, DC, 20332-0103 6: Joint Program Executive Office for Chemical and Biological Defense, Falls Church, VA 22041-3203; Source Info: Dec2005, Vol. 170 Issue 12, p1053; Subject Term: DENGUE viruses; Subject Term: DENGUE; Subject Term: FLAVIVIRUSES; Subject Term: POLYMERASE chain reaction; Subject Term: MOSQUITOES as carriers of disease; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McAvin, James C.
AU - Bowles, David E.
AU - Swaby, James A.
AU - Blount, Keith W.
AU - Blow, Jamie A.
AU - Quintana, Miguel
AU - Hickman, John R.
AU - Atchley, Daniel H.
AU - Niemeyer, Debra M.
T1 - Identification of Aedes aegypti and Its Respective Life Stages by Real-Time Polymerase Chain Reaction.
JO - Military Medicine
JF - Military Medicine
Y1 - 2005/12//
VL - 170
IS - 12
M3 - Article
SP - 1060
EP - 1065
PB - AMSUS
SN - 00264075
AB - An Aedes aegypti-specific, fluorogenic probe hydrolysis (Taq-Man), polymerase chain reaction assay was developed for real-time screening using a field-deployable thermocycler. Laboratory-based testing of A. aegypti, A. aegypti (Trinidad strain), Culex pipiens, Culex quinquefasciatus. Anopheles stephensi, and Ochlerotatus taeniorhynchus individual adult mosquitoes and mixed pools (n = 10) demonstrated 100% concordance in both in vitro sensitivity (six of six samples) and specificity (10 of 10 samples). A single adult A. aegypti was identified in a pool of 100 non-A. aegypti mosquitoes. The limit of detection of A. aegypti egg pools was five individual eggs. Field testing was conducted in central Honduras. An A. aegypti and Culex spp. panel of individual and mixed pools (n = 30) of adult mosquitoes, pupae, and larvae demonstrated 100% concordance in sensitivity (22 of 22 samples) and 97% concordance in specificity (29 of 30 samples), with one false-positive result. Field testing of an A. aegypti and Culex spp. blind panel (n = 16) consisting of individual and mixed pools of adult mosquitoes, pupae, and larvae demonstrated 90% concordance in sensitivity (nine of 10 samples) and 88% concordance in specificity (14 of 16 samples). [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEDES aegypti
KW - MOSQUITOES
KW - POLYMERASE chain reaction
KW - MOSQUITOES as carriers of disease
KW - DENGUE
N1 - Accession Number: 19287011; McAvin, James C. 1 Bowles, David E. 2 Swaby, James A. 2 Blount, Keith W. 3 Blow, Jamie A. 4 Quintana, Miguel 5 Hickman, John R. 1 Atchley, Daniel H. 1 Niemeyer, Debra M. 6,7; Affiliation: 1: Epidemiological Surveillance Division, U.S. Air Force Institute for Environment, Safety, and Occupational Health Analysis, Brooks Air Force Base (now designated Air Force Institute for Operational Health, Brooks City- Base), San Antonio, TX 78235-5237 2: U.S. Air Force Force Protection Battlelab, Lackland Air Force Base, San Antonio, TX 78236-0119 3: U.S. Air Force School of Aerospace Medicine, Brooks Air Force Base, San Antonio, TX 78235-5237 4: Virology Division, U.S. Army Medical Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702-5011 5: Environmental Science Division, U.S. Army Center for Health Promotion and Preventative Medicine-West, Fort Lewis, WA 98433-9500 6: U.S. Air Force Office of the Surgeon General, Bolling Air Force Base, Washington, DC 20332-0103 7: Joint Program Executive Office for Chemical and Biological Defense, Falls Church, VA 22041-3203; Source Info: Dec2005, Vol. 170 Issue 12, p1060; Subject Term: AEDES aegypti; Subject Term: MOSQUITOES; Subject Term: POLYMERASE chain reaction; Subject Term: MOSQUITOES as carriers of disease; Subject Term: DENGUE; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linet, M. S.
AU - Freedman, D. M.
AU - Mohan, A. K.
AU - Doody, M. M.
AU - Ron, E.
AU - Mabuchi, K.
AU - Alexander, B. H.
AU - Sigurdson, A.
AU - Hauptmann, M.
T1 - Incidence of haematopoietic malignancies in US radiologic technologists.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2005/12//
VL - 62
IS - 12
M3 - Article
SP - 861
EP - 867
SN - 13510711
AB - Background: There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation. Aims: To contribute the first incidence risk estimates for haematopoietic malignancies in relation to work history, procedures, practices, and protective measures in a large population of mostly female medical radiation workers. Methods: The investigators followed up 71 894 (77.9% female) US radiologic technologists, first certified during 1926-80, from completion of a baseline questionnaire (1983-89) to return of a second questionnaire (1994-98), diagnosis of a first cancer, death, or 31 August 1998 (731 306 person-years), whichever occurred first. Cox proportional hazards regression was used to compute risks. Results: Relative risks (RR) for leukaemias other than chronic lymphocytic leukaemia (non-CLL, 41 cases) were increased among technologists working five or more years before 1950 (RR = 6.6, 95% CI 1.0 to 41 .9, based on seven cases) or holding patients 50 or more times for x ray examination (RR = 2.6, 95% CI 1.3 to 5.4). Risks of non-CLL leukaemias were not significantly related to the number of years subjects worked in more recent periods, the year or age first worked, the total years worked, specific procedures or equipment used, or personal radiotherapy. Working as a radiologic technologist was not significantly linked with risk of multiple myeloma (28 cases), non-Hodgkin's lymphoma (118 cases), Hodgkin's lymphoma (31 cases), or chronic lymphocytic leukaemia (23 cases). Conclusion: Similar to results for single acute dose and fractionated high dose radiation exposures, there was increased risk for non-CLL leukaemias decades after initial protracted radiation exposure that likely cumulated to low-to-moderate doses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radiotherapy
KW - Chronic lymphocytic leukemia
KW - Hematopoietic system
KW - Radiologic technologists
KW - Radiologists -- United States
KW - Hospital radiological services
KW - United States
N1 - Accession Number: 19142062; Linet, M. S. 1; Email Address: linetm@mail.nih.gov; Freedman, D. M. 1; Mohan, A. K. 2; Doody, M. M. 1; Ron, E. 1; Mabuchi, K. 1; Alexander, B. H. 3; Sigurdson, A. 1; Hauptmann, M. 1; Affiliations: 1: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA.; 2: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA.; 3: Division of Occupational and Environmental Health, University of Minnesota, Minneapolis, MN, USA.; Issue Info: Dec2005, Vol. 62 Issue 12, p861; Subject Term: Radiotherapy; Subject Term: Chronic lymphocytic leukemia; Subject Term: Hematopoietic system; Subject Term: Radiologic technologists; Subject Term: Radiologists -- United States; Subject Term: Hospital radiological services; Subject: United States; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1136/oem.2005.020826
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yousef, Waleed A.
AU - Wagner, Robert F.
AU - Loew, Murray H.
T1 - Estimating the uncertainty in the estimated mean area under the ROC curve of a classifier
JO - Pattern Recognition Letters
JF - Pattern Recognition Letters
Y1 - 2005/12//
VL - 26
IS - 16
M3 - Article
SP - 2600
EP - 2610
SN - 01678655
AB - Abstract: This article considers the problem of binary classification and its assessment in a distribution-free approach. We estimate the area under the ROC curve (a more general performance metric than the error rate) of a classifier using a bootstrap-based estimator. We then use the method of the influence function to estimate the uncertainty of that estimate from the very same bootstrap samples. Monte Carlo trials show that small-sample estimates can be obtained with little bias. [Copyright &y& Elsevier]
AB - Copyright of Pattern Recognition Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BINARY system (Mathematics)
KW - NONPARAMETRIC statistics
KW - METRIC system
KW - BOOTSTRAPPING (Statistics)
KW - ERROR
KW - Bootstrap
KW - Classification
KW - Influence functions
KW - Nonparametric inference
KW - Receiver operating characteristic
N1 - Accession Number: 19496119; Yousef, Waleed A. 1,2; Email Address: wyousef@gwu.edu Wagner, Robert F. 2 Loew, Murray H. 1; Affiliation: 1: Electrical and Computer Engineering, George Washington University, 801 22nd Street, N.W. Washington, DC 20052, United States 2: Center for Devices and Radiological Health (CDRH), Food and Drug Administration (FDA), 12720 Twinbrook Pkwy, Rockville, MD 20850, United States; Source Info: Dec2005, Vol. 26 Issue 16, p2600; Subject Term: BINARY system (Mathematics); Subject Term: NONPARAMETRIC statistics; Subject Term: METRIC system; Subject Term: BOOTSTRAPPING (Statistics); Subject Term: ERROR; Author-Supplied Keyword: Bootstrap; Author-Supplied Keyword: Classification; Author-Supplied Keyword: Influence functions; Author-Supplied Keyword: Nonparametric inference; Author-Supplied Keyword: Receiver operating characteristic; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.patrec.2005.06.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robert Glew
AU - Dorothy Vanderjagt
AU - L.-T. Chuang
AU - Y.-S. Huang
AU - M. Millson
T1 - Nutrient Content of Four Edible Wild Plants from West Africa.
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
Y1 - 2005/12//
VL - 60
IS - 4
M3 - Article
SP - 187
EP - 193
PB - Springer Science & Business Media B.V.
SN - 09219668
AB - Non-cereal plant foods in the Western Sahel of Africa contribute significantly to the diets of local residents, especially during periods of grain shortages. In this paper, we analyze four such plant foods including diyan kwakwa (nut of coconut palm, Cocos nucifera L.), muricin giginya (young shoot of Borassus aethiopum), tsamiya biri (fruit of the tree, Tamarindus indica), and yari (a mixture of lichens, mainly Rimelia reticulate) that grows on ebony trees (Diospyros mespiliformis). They were analyzed for their content of amino acids, fatty acids, and minerals. Although diyan kwakwa contained the highest protein content (27.1%), its protein quality fell below the WHO standard in 3 of 8 essential amino acid categories. Yari and muricingiginya contained moderate levels of good quality protein. Only diyan kwakwa contained calorically significant amount of total fatty acid (24.7%); however, none of the plants contained useful amounts of the essential fatty acids, linoleic acid, or α-linolenic acid. All four plants contained useful amounts of zinc (> 12 μg/g dry weight), while yari contained the most calcium (14.7 mg/g dry weight) and iron (1.41 mg/g), and diyan kwakwa the most copper. All the four plant foods contained lesser amounts of magnesium, molybdenum, or selenium. These data indicate that the four plants contain useful amounts of various essential nutrients that could supplement the diets of populations inhabiting the Western Sahel. [ABSTRACT FROM AUTHOR]
AB - Copyright of Plant Foods for Human Nutrition is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Edible plants
KW - Evaporation (Chemistry)
KW - Edible wild plants
KW - Africa
N1 - Accession Number: 20177742; Robert Glew 1,2,3; Dorothy Vanderjagt 2; L.-T. Chuang 4; Y.-S. Huang 5; M. Millson 5; Affiliations: 1: Michigan State University Center for Advanced Study of International Development East Lansing MI USA East Lansing MI USA; 2: University of New Mexico Department of Biochemistry and Molecular Biology, School of Medicine Albuquerque NM USA Albuquerque NM USA; 3: 1 University of New Mexico Department of Biochemistry and Molecular Biology, MSC08 4670 Albuquerque NM 87131-0001 USA Albuquerque NM 87131-0001 USA; 4: Abbott Laboratories Ross Products Division Columbus OH USA Columbus OH USA; 5: National Institute of Occupational Safety and Health Cincinnati OH USA Cincinnati OH USA; Issue Info: Dec2005, Vol. 60 Issue 4, p187; Thesaurus Term: Edible plants; Thesaurus Term: Evaporation (Chemistry); Subject Term: Edible wild plants; Subject: Africa; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Choi-Kain, Lois
T1 - A Tale of Two Mentors.
JO - Psychiatric Times
JF - Psychiatric Times
Y1 - 2005/12//
VL - 22
IS - 14
M3 - Article
SP - 15
EP - 16
SN - 08932905
AB - Relates the author's experiences in being mentored as a psychiatry student and as a psychiatrist. Details of how a training and supervising analyst in the psychiatry department of the author's university affected her interest in psychoanalysis; Influence of a mentor on her scientific work in psychiatry; Lessons gained from her mentors.
KW - MENTORING
KW - PSYCHIATRY
KW - MEDICAL students
KW - PSYCHOANALYSIS
KW - PATHOLOGICAL psychology
N1 - Accession Number: 20783162; Choi-Kain, Lois 1,2; Affiliation: 1: McLean Administrative Chief Resident, Massachusetts General Hospital-McLean Adult Psychiatry Residency Program 2: Fellow, American Psychoanalytic Association and American Psychiatric Association/Substance Abuse and Mental Health Services Administration; Source Info: Dec2005, Vol. 22 Issue 14, p15; Subject Term: MENTORING; Subject Term: PSYCHIATRY; Subject Term: MEDICAL students; Subject Term: PSYCHOANALYSIS; Subject Term: PATHOLOGICAL psychology; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Contrera, Joseph F.
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Benz, R. Daniel
T1 - In silico screening of chemicals for bacterial mutagenicity using electrotopological E-state indices and MDL QSAR software
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2005/12//
VL - 43
IS - 3
M3 - Article
SP - 313
EP - 323
SN - 02732300
AB - Abstract: Quantitative structure–activity relationship (QSAR) software offers a rapid, cost effective means of prioritizing the mutagenic potential of chemicals. MDL QSAR models were developed using atom-type E-state indices and non-parametric discriminant analysis. Models were developed for Salmonella typhimurium gene mutation, combining results from strains TA97, TA98, TA100, TA1535, TA1536, TA1537, and TA1538 (n =3228), and Escherichia coli gene mutation tests WP2, WP100, and polA (n =472). Composite microbial mutation models (n =3338) were developed combining all Salmonella, E. coli, and the Bacillus subtilis rec spot test study results. The datasets contained 74% non-pharmaceuticals and 26% pharmaceuticals. Salmonella and microbial mutagenesis external validation studies included a total of 1444 and 1485 compounds, respectively. The average specificity, sensitivity, positive predictivity, concordance, and coverage of Salmonella models was 76, 81, 73, 78, and 98%, respectively, with similar performance for the microbial mutagenesis models. MDL QSAR and discriminant analysis provides rapid and highly automated mutagenicity screening software with good specificity, sensitivity, and coverage that is simpler and requires less user intervention than other similar software. MDL QSAR modules for microbial mutagenicity can provide efficient and cost effective large scale screening of compounds for mutagenic potential for the chemical and pharmaceutical industry. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Enterobacteriaceae
KW - Food pathogens
KW - Chemical terrorism
KW - Drug development
KW - E-state indices
KW - Electrotopological
KW - In silico screening
KW - Mutagenicity
KW - Predictive toxicology
KW - QSAR
KW - Setubal principles
N1 - Accession Number: 19009407; Contrera, Joseph F.; Email Address: contrerajf@cder.fda.gov; Matthews, Edwin J. 1; Kruhlak, Naomi L. 1; Benz, R. Daniel 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 5600 Fishers Lane, Rockville, MD 20857, USA; Issue Info: Dec2005, Vol. 43 Issue 3, p313; Thesaurus Term: Salmonella; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Food pathogens; Thesaurus Term: Chemical terrorism; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: E-state indices; Author-Supplied Keyword: Electrotopological; Author-Supplied Keyword: In silico screening; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Predictive toxicology; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Setubal principles; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19009407&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, J. J.
AU - Tsai, C. A.
AU - Young, J. F.
AU - Kodell, R. L.
T1 - Classification ensembles for unbalanced class sizes in predictive toxicology.
JO - SAR & QSAR in Environmental Research
JF - SAR & QSAR in Environmental Research
Y1 - 2005/12//
VL - 16
IS - 6
M3 - Article
SP - 517
EP - 529
SN - 1062936X
AB - This paper investigates the effects of the ratio of positive-to-negative samples on the sensitivity, specificity, and concordance. When the class sizes in the training samples are not equal, the classification rule derived will favor the majority class and result in a low sensitivity on the minority class prediction. We propose an ensemble classification approach to adjust for differential class sizes in a binary classifier system. An ensemble classifier consists of a set of base classifiers; its prediction rule is based on a summary measure of individual classifications by the base classifiers. Two re-sampling methods, augmentation and abatement, are proposed to generate different bootstrap samples of equal class size to build the base classifiers. The augmentation method balances the two class sizes by bootstrapping additional samples from the minority class, whereas the abatement method balances the two class sizes by sampling only a subset of samples from the majority class. The proposed procedure is applied to a data set to predict estrogen receptor binding activity and to a data set to predict animal liver carcinogenicity using SAR (structure-activity relationship) models as base classifiers. The abatement method appears to perform well in balancing sensitivity and specificity. [ABSTRACT FROM AUTHOR]
AB - Copyright of SAR & QSAR in Environmental Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SET theory
KW - SAMPLING (Statistics)
KW - STRUCTURE-activity relationships (Biochemistry)
KW - ESTROGEN
KW - ANALYTICAL chemistry
KW - TOXICOLOGY
KW - Bagging
KW - Cross validation
KW - Ensemble classification
KW - Imbalanced data
KW - Sensitivity
KW - Specificity
N1 - Accession Number: 19451405; Chen, J. J. 1; Email Address: jchen@nctr.fda.gov Tsai, C. A. 2 Young, J. F. 1 Kodell, R. L. 1; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA 2: Institute of Statistical Science, Academia Sinica, Taipei, 11529, Taiwan; Source Info: Dec2005, Vol. 16 Issue 6, p517; Subject Term: SET theory; Subject Term: SAMPLING (Statistics); Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: ESTROGEN; Subject Term: ANALYTICAL chemistry; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Bagging; Author-Supplied Keyword: Cross validation; Author-Supplied Keyword: Ensemble classification; Author-Supplied Keyword: Imbalanced data; Author-Supplied Keyword: Sensitivity; Author-Supplied Keyword: Specificity; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 13p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10659360500468468
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19451405&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - John D. Whited
AU - Santanu K. Datta
AU - Lloyd M. Aiello
AU - Lloyd P. Aiello
AU - Jerry D. Cavallerano
AU - Paul R. Conlin
AU - Mark B. Horton
AU - Robert A. Vigersky
AU - Ronald K. Poropatich
AU - Pratap Challa
AU - Adam W. Darkins
AU - Sven-Erik Bursell
T1 - A Modeled Economic Analysis of a Digital Teleophthalmology System As Used by Three Federal Healthcare Agencies for Detecting Proliferative Diabetic Retinopathy.
JO - Telemedicine & e-Health
JF - Telemedicine & e-Health
Y1 - 2005/12//
VL - 11
IS - 6
M3 - Article
SP - 641
EP - 651
SN - 15305627
AB - The objective of this study was to compare, using a 12-month time frame, the cost-effectivenessof a nonmydriatic digital teleophthalmology system (Joslin Vision Network) versus traditionalclinic-based ophthalmoscopy examinations with pupil dilation to detect proliferativediabetic retinopathy and its consequences. Decision analysis techniques, including MonteCarlo simulation, were used to model the use of the Joslin Vision Network versus conventionalclinic-based ophthalmoscopy among the entire diabetic populations served by the IndianHealth Service, the Department of Veterans Affairs, and the active duty Department ofDefense. The economic perspective analyzed was that of each federal agency. Data sourcesfor costs and outcomes included the published literature, epidemiologic data, administrativedata, market prices, and expert opinion. Outcome measures included the number of true positivecases of proliferative diabetic retinopathy detected, the number of patients treated withpanretinal laser photocoagulation, and the number of cases of severe vision loss averted.In the base-case analyses, the Joslin Vision Network was the dominant strategy in all buttwo of the nine modeled scenarios, meaning that it was both less costly and more effective.In the active duty Department of Defense population, the Joslin Vision Network would bemore effective but cost an extra $1,618 per additional patient treated with panretinal laser photo-coagulation and an additional $13,748 per severe vision loss event averted. Based on our economicmodel, the Joslin Vision Network has the potential to be more effective than clinicbasedophthalmoscopy for detecting proliferative diabetic retinopathy and averting cases ofsevere vision loss, and may do so at lower cost. [ABSTRACT FROM AUTHOR]
AB - Copyright of Telemedicine & e-Health is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPHTHALMOLOGY
KW - MEDICAL telematics
KW - MEDICAL care
KW - MEDICAL informatics
N1 - Accession Number: 21960236; John D. Whited 1 Santanu K. Datta 1 Lloyd M. Aiello 2 Lloyd P. Aiello 2 Jerry D. Cavallerano 2 Paul R. Conlin 3 Mark B. Horton 4 Robert A. Vigersky 5 Ronald K. Poropatich 6 Pratap Challa 7 Adam W. Darkins 8 Sven-Erik Bursell 2; Affiliation: 1: Center for Health Services Research in Primary Care, VA Medical Center, Durham, North Carolina. 2: Beetham Eye Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts. 3: Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts. 4: Phoenix Indian Medical Center, Eye Department, Indian Health Service, Phoenix, Arizona. 5: Endocrinology Service, Walter Reed Army Medical Center, Washington. D.C. 6: Telemedicine Directorate, Walter Reed Army Medical Center, Washington, D.C. 7: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. 8: Chief Consultant, Veterans Healthcare Administration Telemedicine Strategic Healthcare Group, Washington, D.C.; Source Info: Dec2005, Vol. 11 Issue 6, p641; Subject Term: OPHTHALMOLOGY; Subject Term: MEDICAL telematics; Subject Term: MEDICAL care; Subject Term: MEDICAL informatics; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gopee, Neera V.
AU - Cui, Yanyan
AU - Olson, Greg
AU - Warbritton, Alan R.
AU - Miller, Barbara J.
AU - Couch, Letha H.
AU - Wamer, Wayne G.
AU - Howard, Paul C.
T1 - Response of mouse skin to tattooing: use of SKH-1 mice as a surrogate model for human tattooing
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2005/12//
VL - 209
IS - 2
M3 - Article
SP - 145
EP - 158
SN - 0041008X
AB - Abstract: Tattooing is a popular cosmetic practice involving more than 45 million US citizens. Since the toxicology of tattoo inks and pigments used to formulate tattoo inks has not been reported, we studied the immunological impact of tattooing and determined recovery time from this trauma. SKH-1 hairless mice were tattooed using commercial tattoo inks or suspensions of titanium dioxide, cadmium sulfide, or iron oxide, and sacrificed at 0.5, 1, 3, 4, 7, or 14 days post-tattooing. Histological evaluation revealed dermal hemorrhage at 0.5 and 1 day. Acute inflammation and epidermal necrosis were initiated at 0.5 day decreasing in incidence by day 14. Dermal necrosis and epidermal hyperplasia were prominent by day 3, reducing in severity by day 14. Chronic active inflammation persisted in all tattooed mice from day 3 to 14 post-tattooing. Inguinal and axillary lymph nodes were pigmented, the inguinal being most reactive as evidenced by lymphoid hyperplasia and polymorphonuclear infiltration. Cutaneous nuclear protein concentrations of nuclear factor-kappa B were elevated between 0.5 and 4 days. Inflammatory and proliferative biomarkers, cyclooxygenase-1, cyclooxygenase-2, and ornithine decarboxylase protein levels were elevated between 0.5 and 4 days in the skin and decreased to control levels by day 14. Interleukin-1 beta and interleukin-10 were elevated in the lymph nodes but suppressed in the tattooed skin, with maximal suppression occurring between days 0.5 and 4. These data demonstrate that mice substantially recover from the tattooing insult by 14 days, leaving behind pigment in the dermis and the regional lymph nodes. The response seen in mice is similar to acute injury seen in humans, suggesting that the murine model might be a suitable surrogate for investigating the toxicological and phototoxicological properties of ingredients used in tattooing. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ferric oxide
KW - Lymph nodes
KW - Inflammation
KW - Gangrene
KW - COX-1
KW - COX-2
KW - IL-1β
KW - IL-10
KW - Lymph node
KW - NF-κB
KW - ODC
KW - Skin
KW - Tattoo
N1 - Accession Number: 19008869; Gopee, Neera V. 1,2; Cui, Yanyan 1,2; Olson, Greg 3; Warbritton, Alan R. 3; Miller, Barbara J. 1,2; Couch, Letha H. 1; Wamer, Wayne G. 4; Howard, Paul C. 1,2; Email Address: PHoward@nctr.fda.gov; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; 2: NTP Center for Phototoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; 3: Toxicologic Pathology Associates, Jefferson, AR 72079, USA; 4: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Issue Info: Dec2005, Vol. 209 Issue 2, p145; Thesaurus Term: Ferric oxide; Subject Term: Lymph nodes; Subject Term: Inflammation; Subject Term: Gangrene; Author-Supplied Keyword: COX-1; Author-Supplied Keyword: COX-2; Author-Supplied Keyword: IL-1β; Author-Supplied Keyword: IL-10; Author-Supplied Keyword: Lymph node; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: ODC; Author-Supplied Keyword: Skin; Author-Supplied Keyword: Tattoo; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.taap.2005.04.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19008869&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Ned, Renée M.
AU - Moore, Julie M.
AU - Udhayakumar, Venkatachalam
T1 - Response to Pearson: Parasites, pregnancy, prolactin and pandemics?
JO - Trends in Parasitology
JF - Trends in Parasitology
Y1 - 2005/12//
VL - 21
IS - 12
M3 - Letter
SP - 556
EP - 557
SN - 14714922
N1 - Accession Number: 19011410; Ned, Renée M. 1 Moore, Julie M. 2 Udhayakumar, Venkatachalam 1; Email Address: vxu0@cdc.gov; Affiliation: 1: Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Chamblee, GA 30341, USA 2: Center for Tropical and Emerging Global Diseases and Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Source Info: Dec2005, Vol. 21 Issue 12, p556; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.pt.2005.09.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19011410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mode, Nicolle A.
AU - Hackett, Elizabeth J.
AU - Conway, George A.
T1 - Unique Occupational Hazards of Alaska: Animal- Related Injuries.
JO - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
JF - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
Y1 - 2005///Winter2005
VL - 16
IS - 4
M3 - Article
SP - 185
EP - 191
PB - Allen Press Publishing Services Inc.
SN - 10806032
AB - Objective.--During 1992-2000, an average of 40 fatal occupational injuries and 12 400 nonfatal occupational injuries and illnesses related to animals were recorded each year in the United States, most involving domestic farm animals. Although Alaska has a relatively small farming industry, it supports several industries that require workers to regularly be in contact with animals. This study examines the pattern and characteristics of animal-related occupational injuries in Alaska. Methods.--Two data sources were accessed: the Alaska Trauma Registry for nonfatal injuries requiring hospitalization and the Alaska Occupational Injury Surveillance System for fatal injuries. The case definition included events in which the source of the injury was an animal or animal product (Occupational Injury and Illness Classification Manual source code 51). Results.--In Alaska during 1991-2000, there were 43 animal-related occupational injuries requiring hospitalization and 25 animal-related fatalities. There were only 2 fatal events: 1 bird-strike aircraft accident killing 24 military personnel and 1 bear attack. The majority of the nonfatal injury events were related to marine wildlife (n = 20), with the rest related to either domesticated (n = 11) or nondomesticated (n = 12) mammals. Of events reporting a hospital charge (23 of 43), the average cost was over $9700 per person. Conclusions.--The catastrophic aircraft crash increased bird-control efforts near airports around the state. The nonfatal animal-related injuries have received less notice, although they result in thousands of dollars in hospital costs and lost workdays. Fishing-industry workers in particular should be made aware of potential injuries and educated on how to treat them when away from definitive medical care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.) is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational hazards
KW - Industrial safety
KW - Domestic animals
KW - Work environment
KW - Alaska
KW - animal
KW - fatality
KW - occupational injury or illness
KW - workplace
N1 - Accession Number: 19211556; Mode, Nicolle A. 1; Email Address: nmode@cdc.gov; Hackett, Elizabeth J. 2; Conway, George A. 1; Affiliations: 1: Alaska Field Station, National Institute for Occupational Safety, and Health, Centers for Disease Control and Prevention, Anchorage, AK; 2: New York University School of Medicine, New York, NY; Issue Info: Winter2005, Vol. 16 Issue 4, p185; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial safety; Thesaurus Term: Domestic animals; Subject Term: Work environment; Subject: Alaska; Author-Supplied Keyword: animal; Author-Supplied Keyword: fatality; Author-Supplied Keyword: occupational injury or illness; Author-Supplied Keyword: workplace; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-00757-003
AN - 2006-00757-003
AU - Hayes, Celia
AU - Gambrell, Alan
AU - Young, Steven
AU - Conviser, Richard
T1 - Using data to make decisions: Planning HIV/AIDS care under the Ryan White Care Act.
T3 - Uses of HIV and Other Public Health Data for HIV Prevention and Care Planning
JF - AIDS Education and Prevention
JO - AIDS Education and Prevention
Y1 - 2005/12//
VL - 17
IS - SupplB
SP - 17
EP - 25
CY - US
PB - Guilford Publications
SN - 0899-9546
AD - Hayes, Celia, Health Resources and Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Room 7-29, Rockville, MD, US, 20857
N1 - Accession Number: 2006-00757-003. Partial author list: First Author & Affiliation: Hayes, Celia; Health Resources and Services Administration, Rockville, MD, US. Release Date: 20060213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; AIDS Prevention; Decision Making; HIV; Program Development. Minor Descriptor: Civil Law; Communities; Data Collection; Government Policy Making; Health Care Services. Classification: Immunological Disorders (3291); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2005.
AB - This article describes the challenges of using data to plan and fund HIV/AIDS care services for underserved populations under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act. It also outlines methods that have been developed by the Health Resources and Services Administration of the U.S. Department of Health and Human Services to assist community planning groups in using data to decide how to target limited federal resources under the CARE Act. Use of CARE Act dollars is guided largely by an array of legislatively identified priority areas, such as targeting of low income HIV-infected individuals who are not in care for their HIV disease. CARE Act program guidance covers the use of epidemiologic HIV and AIDS case data, quantification of unmet need for HIV care, guidance on making objective decisions on priorities for funding within a community planning process, and other instructions on the use of data in making decisions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV prevention
KW - care services
KW - Ryan White Comprehensive AIDS Resources Emergency Act
KW - data usage
KW - community decision making
KW - AIDS prevention programs
KW - 2005
KW - AIDS
KW - AIDS Prevention
KW - Decision Making
KW - HIV
KW - Program Development
KW - Civil Law
KW - Communities
KW - Data Collection
KW - Government Policy Making
KW - Health Care Services
KW - 2005
DO - 10.1521/aeap.2005.17.Supplement B.17
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00757-003&site=ehost-live&scope=site
UR - chayes@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-00970-001
AN - 2006-00970-001
AU - Sale, Elizabeth
AU - Sambrano, Soledad
AU - Springer, J. Fred
AU - Peña, Cynthia
AU - Pan, Wei
AU - Kasim, Rafa
T1 - Family Protection and Prevention of Alcohol Use Among Hispanic Youth at High Risk.
JF - American Journal of Community Psychology
JO - American Journal of Community Psychology
JA - Am J Community Psychol
Y1 - 2005/12//
VL - 36
IS - 3-4
SP - 195
EP - 205
CY - Germany
PB - Springer
SN - 0091-0562
SN - 1573-2770
AD - Sale, Elizabeth, Missouri Institute of Mental Health, 5400 Arsenal Street, St. Louis, MO, US, 63139
N1 - Accession Number: 2006-00970-001. PMID: 16389495 Partial author list: First Author & Affiliation: Sale, Elizabeth; Missouri Institute of Mental Health, St. Louis, MO, US. Other Publishers: Kluwer Academic/Plenum Publishers; Plenum Publishing Corp.; Wiley-Blackwell Publishing Ltd. Release Date: 20060306. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Sale, Elizabeth. Major Descriptor: Adolescent Psychology; Alcohol Abuse; Family Intervention; Prevention; Latinos/Latinas. Minor Descriptor: At Risk Populations; Family Relations; Parental Attitudes; Risk Factors. Classification: Promotion & Maintenance of Health & Wellness (3365); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Dec, 2005.
AB - Research regarding prevention strategies for Hispanic youth stress the importance of family interventions because of the particular importance of family as a protective factor within the Hispanic community. Starting in 1995, the Center for Substance Abuse Prevention conducted the National Cross-Site Evaluation of High Risk Youth Programs, a 5-year drug and alcohol prevention study with a sample of approximately 10,500 youth, including nearly 3,000 Hispanic youth. Youth were surveyed regarding their alcohol use patterns and risk and protective factors, with several measures of family relationships, including family connectedness, family supervision, and parental attitudes toward their child's alcohol use. Analyses indicate that family factors are highly linked to alcohol use among Hispanics, particularly among Hispanic females. Longitudinal growth curve analyses indicate that improving the connections that young Hispanic females have to their parents can have positive long-term effects on delaying or reducing their alcohol use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Hispanic youth
KW - family protection
KW - alcohol use prevention
KW - at risk populations
KW - family interventions
KW - 2005
KW - Adolescent Psychology
KW - Alcohol Abuse
KW - Family Intervention
KW - Prevention
KW - Latinos/Latinas
KW - At Risk Populations
KW - Family Relations
KW - Parental Attitudes
KW - Risk Factors
KW - 2005
U1 - Sponsor: National Institute of Justice. Other Details: Dissertation Fellowship. Recipients: Sale, Elizabeth
U1 - Sponsor: National Institute of Justice. Grant: 86-IJ-CX-0033; 93-IJ-CX-0031. Recipients: Sambrano, Soledad
DO - 10.1007/s10464-005-8614-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00970-001&site=ehost-live&scope=site
UR - liz.sale@mimh.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-00814-020
AN - 2006-00814-020
AU - Leaf, Philip J.
AU - Keys, Susan G.
T1 - Collaborating for Violence Prevention: Training Health Professionals to Work with Schools.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2005/12//
VL - 29
IS - 5,Suppl2
SP - 279
EP - 287
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Leaf, Philip J., Center of Prevention of Youth Violence, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 819, Baltimore, MD, US, 21205
N1 - Accession Number: 2006-00814-020. PMID: 16376731 Partial author list: First Author & Affiliation: Leaf, Philip J.; Center for the Prevention of Youth Violence, Johns Hopkins University, Baltimore, MD, US. Release Date: 20060428. Correction Date: 20160516. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Personnel Training; Public Health Services; Violence; Health Personnel. Minor Descriptor: Public Health; Schools. Classification: Professional Education & Training (3410). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2005.
AB - The issue of youth violence continues to be a pressing public health problem. Increasingly schools are adopting a public health framework to address this problem and could benefit from the expertise of health professionals. The article explores opportunities for collaboration with schools, recommendations for successful collaboration, and implications for training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violence prevention
KW - health professionals training
KW - public health services
KW - school collaboration
KW - 2005
KW - Personnel Training
KW - Public Health Services
KW - Violence
KW - Health Personnel
KW - Public Health
KW - Schools
KW - 2005
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: CCR318627. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: MH67948. Recipients: No recipient indicated
DO - 10.1016/j.amepre.2005.08.032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00814-020&site=ehost-live&scope=site
UR - pleaf@jhsph.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16135-003
AN - 2005-16135-003
AU - Wolff, Nancy
AU - Pogorzelski, Wendy
T1 - Measuring the effectiveness of mental health courts: Challenges and recommendations.
T3 - Mental Health Courts
JF - Psychology, Public Policy, and Law
JO - Psychology, Public Policy, and Law
JA - Psychol Public Policy Law
Y1 - 2005/12//
VL - 11
IS - 4
SP - 539
EP - 569
CY - US
PB - American Psychological Association
SN - 1076-8971
SN - 1939-1528
AD - Wolff, Nancy, Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901-1293
N1 - Accession Number: 2005-16135-003. Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20060103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adjudication; Criminal Justice; Measurement; Mentally Ill Offenders; Program Evaluation. Minor Descriptor: Evaluation Criteria; Experimentation. Classification: Criminal Law & Adjudication (4230); Psychological Disorders (3210). Population: Human (10). Location: US. References Available: Y. Page Count: 31. Issue Publication Date: Dec, 2005. Copyright Statement: American Psychological Association. 2005.
AB - How will we know if mental health courts are effective? The answers provided by future evaluation research will reflect the extent to which the social and procedural complexity of mental health courts drives the research design and plan. This article identifies the research challenges associated with studying the effectiveness of an intervention that is nonstandardized by nature and highly dependent on macro and local influences within the environment as well as personal preferences and relationship dynamics within the intervention itself. Explored are the research challenges related to isolating the independent effects associated with mental health courts. The article concludes with recommendations for how best to evaluate mental health courts to inform best practice and policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health court
KW - Law Enforcement and Mental Health Project
KW - diversion-to-treatment
KW - effectiveness evaluation
KW - measurement
KW - research challenges
KW - 2005
KW - Adjudication
KW - Criminal Justice
KW - Measurement
KW - Mentally Ill Offenders
KW - Program Evaluation
KW - Evaluation Criteria
KW - Experimentation
KW - 2005
DO - 10.1037/1076-8971.11.4.539
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16135-003&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12254-012
AN - 2006-12254-012
AU - Mulvey, Kevin P.
AU - Atkinson, Donna Durant
AU - Avula, Deepa
AU - Luckey, J. William
T1 - Using the Internet to Measure Program Performance.
JF - American Journal of Evaluation
JO - American Journal of Evaluation
JA - Am J Eval
Y1 - 2005/12//
VL - 26
IS - 4
SP - 587
EP - 597
CY - US
PB - Sage Publications
SN - 1098-2140
SN - 1557-0878
AD - Mulvey, Kevin P., Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Lane, Suite 4-1019, Rockville, MD, US, 20857
N1 - Accession Number: 2006-12254-012. Partial author list: First Author & Affiliation: Mulvey, Kevin P.; Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20070402. Correction Date: 20111017. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Computer Applications; Funding; Government Agencies; Internet; Program Evaluation. Minor Descriptor: Monitoring. Classification: Psychometrics & Statistics & Methodology (2200); Social Structure & Organization (2910). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2005.
AB - The Internet and World Wide Web are increasingly used to accelerate progress in a variety of fields. These applications go beyond the traditional technology- or computer-related fields and have expanded to nontechnical fields, which have benefited greatly from the use of the Web as a data-gathering and management support tool. The purpose of this article is to examine the Web's use by a federal funding agency and its grantees for performance measurement and program monitoring. The analysis is based on the Center for Substance Abuse Treatment's (CSAT) implementation of a Web-based data entry and reporting system. This system is used both as a mechanism for monitoring CSAT's grant portfolios and as a tool to manage performance. The authors conclude with a discussion of the issues surrounding the effectiveness and efficiency of using the Web to measure and monitor program performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Internet
KW - measurement of program performance
KW - program monitoring
KW - federal funding agency
KW - 2005
KW - Computer Applications
KW - Funding
KW - Government Agencies
KW - Internet
KW - Program Evaluation
KW - Monitoring
KW - 2005
DO - 10.1177/1098214005281320
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12254-012&site=ehost-live&scope=site
UR - kevin.mulvey@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03051-003
AN - 2006-03051-003
AU - Gebo, Kelly A.
AU - Fleishman, John A.
AU - Moore, Richard D.
T1 - Hospitalizations for Metabolic Conditions, Opportunistic Infections, and Injection Drug Use Among HIV Patients: Trends Between 1996 and 2000 in 12 States.
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2005/12//
VL - 40
IS - 5
SP - 609
EP - 616
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Gebo, Kelly A., Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 442, Baltimore, MD, 21287
N1 - Accession Number: 2006-03051-003. Partial author list: First Author & Affiliation: Gebo, Kelly A.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20060717. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; HIV; Hospitalization; Infectious Disorders; Trends. Minor Descriptor: Cerebrovascular Disorders; Death and Dying; Drug Therapy; Epidemiology; Intravenous Drug Usage. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40); Inpatient (50). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2005.
AB - Background: Rapid changes in HIV epidemiology and highly active antiretroviral therapy (HAART) may have resulted in recent changes in patterns of inpatient utilization. Objective: To examine trends in inpatient diagnoses and mortality in HIV patients. Design/Setting/Patients: Serial cross-sectional analyses of HIV patients hospitalized in 1996, 1998, and 2000, using hospital discharge data from the Healthcare Costs and Utilization Project for 12 states. Each hospitalization was classified as an opportunistic illness, complication of injection drug use (IDU), liver-related complication, ischemic heart disease, cerebrovascular disease, non-Pneumocystis carinii pneumonia (PCP), diabetes, or chronic hepatitis C virus (HCV). Main Outcome Measures: Number of hospital admissions, inpatient mortality. Results: We evaluated 316,963 admissions that occurred between 1996 and 2000, with an overall mortality of 7%. Hospitalizations for opportunistic infections significantly decreased from 40% to 27% of all HIV-related admissions. The overall proportion of IDU complications remained relatively stable (6%) each year. Hospitalizations increased for liver-related complications from 8% to 13% and for chronic HCV from 1% to 5% in this period. The number of hospitalizations for cerebrovascular disease and for ischemic heart disease was relatively negligible in all years. Overall, inpatient mortality decreased between 1996 and 2000. Relatively higher mortality was observed among African Americans, Hispanics, those with Medicaid, those with Medicare, and the uninsured, however. Opportunistic infections and liver-related complications were associated with greater inpatient mortality. Conclusion: Results do not show a significant recent rise in HIV-related inpatient utilization. Admissions to treat opportunistic infections have declined precipitously, consistent with the effects of HAART. Although not dramatic, liver-related disease is an increasing cause of hospitalization in HIV+ patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospitalizations
KW - infections
KW - drug injection
KW - HIV patients
KW - antiretroviral therapy
KW - heart disease
KW - epidemiology
KW - trends
KW - 2005
KW - AIDS Prevention
KW - HIV
KW - Hospitalization
KW - Infectious Disorders
KW - Trends
KW - Cerebrovascular Disorders
KW - Death and Dying
KW - Drug Therapy
KW - Epidemiology
KW - Intravenous Drug Usage
KW - 2005
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: K 23 DA 00523; K24 DA 00432. Recipients: No recipient indicated
U1 - Sponsor: Johns Hopkins University, Center for AIDS Research (CFAR). Grant: P30 AI42855. Recipients: No recipient indicated
DO - 10.1097/01.qai.0000171727.55553.78
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03051-003&site=ehost-live&scope=site
UR - kgebo@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-15914-001
AN - 2005-15914-001
AU - Zinn, Jacqueline
AU - Spector, William
AU - Hsieh, Lillian
AU - Mukamel, Dana B.
T1 - Do trends in the reporting of quality measures on the nursing home compare web site differ by nursing home characteristics?
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2005/12//
VL - 45
IS - 6
SP - 720
EP - 730
CY - US
PB - Gerontological Society of America
SN - 0016-9013
SN - 1758-5341
AD - Zinn, Jacqueline, Department of Risk, Insurance and Healthcare Management, Fox School of Business and Management, Temple University, 413 Ritter Annex, Philadelphia, PA, US, 19122
N1 - Accession Number: 2005-15914-001. PMID: 16326653 Partial author list: First Author & Affiliation: Zinn, Jacqueline; Department of Risk, Insurance and Healthcare Management, Temple University, Philadelphia, PA, US. Other Publishers: Oxford University Press. Release Date: 20060410. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Internet; Medicaid; Medicare; Nursing Homes; Quality of Care. Minor Descriptor: Websites. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2005.
AB - Purpose: This study examines the relationship between the first set of quality measures (QMs) published by the Centers for Medicare and Medicaid Services on the Nursing Home Compare Web site and five nursing home structural characteristics: ownership, chain affiliation, size, occupancy, and hospital-based versus freestanding status. Design and Methods: Using robust linear regressions, we examined the values of the QMs at first publication and their change over the first five reporting periods, in relation to facility characteristics. Results: There were significant baseline differences associated with these facility characteristics. Pain, physical restraints, and delirium exhibit a clear downward trend, with differences between the first QM reporting period and the fifth ranging from 12.7% to 46.0%. However, there were only minimal differences in trends associated with facility characteristics. This suggests that the relative position of facilities on these measures did not change much within this time period. The variation by facility type was larger for the short-stay QMs than for the long-stay measures. Implications: Those QMs that show an improvement exhibit it across all types of facilities, irrespective of initial quality levels. Although a number of alternatives may explain this positive trend, the trend itself suggests that report cards, to the extent that they are effective, are so for all facility types but only some QMs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nursing homes
KW - websites
KW - medicare
KW - medicaid
KW - quality measures
KW - facility characteristics
KW - 2005
KW - Internet
KW - Medicaid
KW - Medicare
KW - Nursing Homes
KW - Quality of Care
KW - Websites
KW - 2005
DO - 10.1093/geront/45.6.720
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-15914-001&site=ehost-live&scope=site
UR - Jacqueline.Zinn@temple.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16007-001
AN - 2005-16007-001
AU - Kowalski-Trakofler, Kathleen M.
AU - Steiner, Lisa J.
AU - Schwerha, Diana J.
T1 - Safety considerations for the aging workforce.
JF - Safety Science
JO - Safety Science
JA - Saf Sci
Y1 - 2005/12//
VL - 43
IS - 10
SP - 779
EP - 793
CY - Netherlands
PB - Elsevier Science
SN - 0925-7535
AD - Kowalski-Trakofler, Kathleen M., National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA, US, 15236
N1 - Accession Number: 2005-16007-001. Other Journal Title: Journal of Occupational Accidents. Partial author list: First Author & Affiliation: Kowalski-Trakofler, Kathleen M.; National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, US. Release Date: 20060410. Correction Date: 20151228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Gerontology; Health Care Psychology; Occupational Safety; Personnel. Minor Descriptor: Business; Intervention; Motor Processes. Classification: Gerontology (2860). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: National Health Interview Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 2005.
AB - This paper discusses some of the psychological and physical issues of the aging workforce based on recent literature. Descriptions of physical aging and cognitive aging are presented and the relationship of these factors to worker safety, especially those relevant to the mining industry, is discussed. The authors include suggestions for the integration of this knowledge in the design of appropriate safety and health interventions for older workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - safety considerations
KW - older workers
KW - psychological issues
KW - physical issues
KW - cognitive ability
KW - worker safety
KW - mining industry
KW - health intervention
KW - 2005
KW - Cognitive Ability
KW - Gerontology
KW - Health Care Psychology
KW - Occupational Safety
KW - Personnel
KW - Business
KW - Intervention
KW - Motor Processes
KW - 2005
DO - 10.1016/j.ssci.2005.08.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16007-001&site=ehost-live&scope=site
UR - kkowalski@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16449-001
AN - 2005-16449-001
AU - Kong, Yong-Ku
AU - Lowe, Brian D.
T1 - Evaluation of handle diameters and orientations in a maximum torque task.
JF - International Journal of Industrial Ergonomics
JO - International Journal of Industrial Ergonomics
JA - Int J Ind Ergon
Y1 - 2005/12//
VL - 35
IS - 12
SP - 1073
EP - 1084
CY - Netherlands
PB - Elsevier Science
SN - 0169-8141
AD - Kong, Yong-Ku, Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2005-16449-001. Partial author list: First Author & Affiliation: Kong, Yong-Ku; Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Motor Processes; Muscles; Physical Comfort. Minor Descriptor: Human Sex Differences. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Dec, 2005.
AB - The effects of gender, handle diameter (25-50 mm), and handle orientation (horizontal and vertical) on the perceived comfort, torque, total finger force, and efficiency of flexor and extensor muscle activity were examined in a maximum torque task. A 16-force sensor glove system was applied to measure finger and phalangeal forces, and a surface EMG was recorded to investigate muscle activities in the torque task. Average maximum torque in the horizontal orientation was about 23.4% more than that in the vertical orientation. The maximum torque was the largest with the 45 and 50 mm diameter handles and least with the 25 mm diameter handle. In both orientations, torque increased as the handle diameter increased, whereas total finger force showed a decreasing pattern which can explain the positive and non-linear correlation between torque output and handle diameter. The efficiency of muscle activity in both orientations followed a similar trend with the torque output for the handle diameters (i.e., the efficiency increased when the handle diameter increased). 35-45 mm handles were rated as the most comfortable for maximum torque exertions. According to a polynomial regression, 37-44 mm and 41-48 mm diameter handles (23.3% of the user's hand length) maximized perceived comfort and were thus recommended for females and males, respectively in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - handle diameters
KW - handle orientations
KW - maximum torque task
KW - gender
KW - finger force
KW - flexor
KW - extensor muscle activity
KW - perceived comfort
KW - ergonomics
KW - 2005
KW - Human Factors Engineering
KW - Motor Processes
KW - Muscles
KW - Physical Comfort
KW - Human Sex Differences
KW - 2005
DO - 10.1016/j.ergon.2005.04.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16449-001&site=ehost-live&scope=site
UR - ykong@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-15542-005
AN - 2005-15542-005
AU - Reynolds, P. Preston
AU - Kamei, Robert K.
AU - Sundquist, Janet
AU - Khanna, Niharika
AU - Palmer, Elissa J.
AU - Palmer, Trish
T1 - Using the PRACTICE Mnemonic to Apply Cultural Competency to Genetics in Medical Education and Patient Care.
JF - Academic Medicine
JO - Academic Medicine
JA - Acad Med
Y1 - 2005/12//
VL - 80
IS - 12
SP - 1107
EP - 1113
CY - US
PB - Lippincott Williams & Wilkins
SN - 1040-2446
SN - 1938-808X
AD - Reynolds, P. Preston, Primary Care Medical Education Branch, Division of Medicine and Dentistry, Health Resources and Services Administration, 5600 Fishers Lane, Parklawn Bldg, Rm. 9A-20, Rockville, MD, US, 20857
N1 - Accession Number: 2005-15542-005. PMID: 16306282 Other Journal Title: Journal of Medical Education. Partial author list: First Author & Affiliation: Reynolds, P. Preston; Primary Care Medical Education Branch, Division of Medicine and Dentistry, Health Resources and Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Institutional Authors: GPC Working Group Members. Release Date: 20060213. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Cultural Sensitivity; Genetics; Health Care Services; Medical Education. Classification: Professional Education & Training (3410). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2005.
AB - Medical education curricula increasingly are incorporating courses on cultural competency and skills development in working with ethnically diverse patient populations as well as courses on genetics and genomics. The authors support these efforts and believe the next step is integration of genetics into cultural competency programs and similarly, cultural competency into genetics curricula. In this paper, the authors describe the work of the Genetics in Primary Care Faculty Development Working Group on Cultural Competency, a federally-funded initiative to prepare generalist faculty to teach genetics as part of ambulatory education. Over a 12-month period, this team wrote a module on cultural competency and nine new clinical cases, and developed the PRACTICE mnemonic (prevalence, risk, attitude, communication, testing, investigation, consent, empowerment) to help health care professionals integrate cultural competency skills in genetics into primary care. More specifically, the PRACTICE mnemonic integrates information emerging from experts in health disparities and doctor-patient communication to build a comprehensive model for addressing the relevance of culture and ethnicity in the delivery of genetic services. Lastly, this paper illustrates a systematic method of covering key areas of cultural competency through discussion of a patient with a genetic disorder as well as presents an argument as to why cultural competency is highly relevant to the delivery of genetic services especially as part of generalists' clinical practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - PRACTICE Mnemonic
KW - cultural competency
KW - genetics
KW - medical education
KW - patient care
KW - 2005
KW - Cross Cultural Differences
KW - Cultural Sensitivity
KW - Genetics
KW - Health Care Services
KW - Medical Education
KW - 2005
DO - 10.1097/00001888-200512000-00008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-15542-005&site=ehost-live&scope=site
UR - preston.reynolds@hrsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16150-024
AN - 2005-16150-024
AU - Ozarin, Lucy D.
T1 - Letters: Past and current views on the use of seclusion and restraint in treatment.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/12//
VL - 56
IS - 12
SP - 1621
EP - 1622
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2005-16150-024. PMID: 16339632 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Ozarin, Lucy D.; U.S. Public Health Service, US. Release Date: 20060206. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Letter. Language: English. Major Descriptor: Patient Seclusion; Physical Restraint; Psychiatric Hospitals. Classification: Inpatient & Hospital Services (3379). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Dec, 2005.
AB - The September issue of Psychiatric Services presents encouraging news that agitated patients are being successfully treated without the use of restraint or seclusion. The question of restraint has a long history of disagreement among physicians in mental hospitals. Nineteenth-century British psychiatrists were opposed to mechanical restraint, although 'holding' by attendants was allowed. In 1875, when Dr. John Bucknill, a former superintendent of a British asylum, visited American asylums, he found that the private ones used little or no restraint but the public mental hospitals used restraint often. Perhaps the articles in Psychiatric Services reflect a new era in the treatment of mental patients in hospitals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental hospitals
KW - seclusion
KW - restraint
KW - asylum
KW - 2005
KW - Patient Seclusion
KW - Physical Restraint
KW - Psychiatric Hospitals
KW - 2005
DO - 10.1176/appi.ps.56.12.1621-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16150-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16150-037
AN - 2005-16150-037
AU - Biebel, Kathleen
T1 - Review of A girl becomes a comma like that.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2005/12//
VL - 56
IS - 12
SP - 1630
EP - 1630
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2005-16150-037. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Biebel, Kathleen; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060206. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Caregivers; Friendship; Human Females; Love; Psychosexual Behavior. Minor Descriptor: Breast Neoplasms; Daughters; Death and Dying. Classification: Marriage & Family (2950); Group & Interpersonal Processes (3020). Population: Human (10); Female (40). Reviewed Item: Glatt, Lisa. A girl becomes a comma like that=New York, Simon & Schuster, 2004, 290 pages, $22; 2004. Page Count: 1. Issue Publication Date: Dec, 2005.
AB - Reviews the book, A girl becomes a comma like that by Lisa Glatt (2004). Lisa Glatts' debut novel tackles the complexities of women's relationships with friends and family, their bodies, and themselves. Rachel Spark, a 30-something university poetry teacher, is the 'girl' looking for love and meaning in a life burdened by having to care for her sick mother, in between her sexual encounters with various unsuitable men. Rachel tells her story in a first-person account while intertwining third person accounts of three other young women. What connects these women is exactly what keeps them apart from each other and everybody else; they share a common loneliness they try to fill with sex. Juxtaposed against these women is Rachel's mother, who while dying of breast cancer at the age of 59 is coming to terms with her fading beauty and embracing a simpler, less complicated life. This chaotic story is told with tenderness and humor, and without judgment. Although some characters receive more attention than others, all have full and robust traits that will pique the reader's interest. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breast cancer
KW - women's relationships
KW - friendship
KW - death and dying
KW - caregivers
KW - love
KW - sex
KW - 2005
KW - Caregivers
KW - Friendship
KW - Human Females
KW - Love
KW - Psychosexual Behavior
KW - Breast Neoplasms
KW - Daughters
KW - Death and Dying
KW - 2005
U2 - Glatt, Lisa. (2004); A girl becomes a comma like that; New York, Simon & Schuster, 2004, 290 pages, $22
DO - 10.1176/appi.ps.56.12.1630
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16150-037&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02163-003
AN - 2006-02163-003
AU - Sofaer, Shoshanna
AU - Crofton, Christine
AU - Goldstein, Elizabeth
AU - Hoy, Elizabeth
AU - Crabb, Jenny
T1 - What Do Consumers Want to Know about the Quality of Care in Hospitals?
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2005/12//
VL - 40
IS - 6,part2
SP - 2018
EP - 2036
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Sofaer, Shoshanna, School of Public Affairs, Baruch College, 17 Lexington Avenue, Box D615, New York, NY, US, 10010
N1 - Accession Number: 2006-02163-003. Partial author list: First Author & Affiliation: Sofaer, Shoshanna; School of Public Affairs, Baruch College, New York, NY, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060522. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Attitudes; Hospitalized Patients; Hospitals; Quality of Care. Minor Descriptor: Test Construction. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: CAHPS Hospital Survey. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Dec, 2005.
AB - Objective: To guide the development of the Consumer Assessments of Healthcare Providers and Systems (CAHPS®) Hospital Survey by identifying which domains of hospital quality included in a survey of recent hospital patients, and which survey items within those domains, would be of greatest interest to consumers and patients. Data Sources/Study Setting: Primary data were collected in four cities (Baltimore, Los Angeles, Phoenix, and Orlando), from a demographically varied mix of people of whom most, but not all, had recently been hospitalized or had a close loved one hospitalized. Study Design/Data Collection Method: A total of 16 focus groups were held in these four cities. Groups were structured to be homogeneous with respect to type of health care coverage (Medicare, non-Medicare), and type of recent hospital experience (urgent admission, elective admission, maternity admission, no admission). They were heterogeneous with respect to race/ethnicity, gender, and educational attainment. In addition to moderated discussions, focus group participants completed a pregroup questionnaire and various paper and pencil exercises during the groups. Principal Findings: A wide range of features were identified by participants as being relevant to hospital quality. Many were consonant with domains and items in the CAHPS Hospital Survey; however, some addressed structural features of hospitals and hospital outcomes that are not best derived from a patient experience survey. When shown the domains and items being considered for inclusion in the CAHPS Hospital Survey, participants were most interested in items relating to doctor communication with patients, nurse and hospital staff communication with patients, responsiveness to patient needs, and cleanliness of the hospital room and bathroom. Findings were quite consistent across groups regardless of location and participant characteristics. Conclusions: Consumers and patients have a high degree of interest in hospital quality and found a very high proportion of the items being considered for the CAHPS Hospital Survey to be so important they would consider changing hospitals in response to information about them. Hospital choice may well be constrained for patients, but publicly reported information from a patient perspective can also be used to support patient discussions with facilities and physicians about how to ensure patients have the best hospital experience possible. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality of care
KW - hospitals
KW - hospital patients
KW - Consumer Assessments of Healthcare Providers and Systems Hospital Survey
KW - test development
KW - 2005
KW - Client Attitudes
KW - Hospitalized Patients
KW - Hospitals
KW - Quality of Care
KW - Test Construction
KW - 2005
DO - 10.1111/j.1475-6773.2005.00473.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02163-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106430985
T1 - Using data to make decisions: planning HIV/AIDS care under the Ryan White CARE Act.
AU - Hayes C
AU - Gambrell A
AU - Young S
AU - Conviser R
Y1 - 2005/12/02/Dec2005 Supplement
N1 - Accession Number: 106430985. Language: English. Entry Date: 20060428. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Dec2005 Supplement. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. NLM UID: 9002873.
KW - Decision Making
KW - HIV Infections -- Therapy
KW - Patient Care Plans -- Administration
KW - Data Collection
KW - Financing, Government -- Legislation and Jurisprudence -- United States
KW - Health Services Needs and Demand
KW - United States
SP - 17
EP - 25
JO - AIDS Education & Prevention
JF - AIDS Education & Prevention
JA - AIDS EDUC PREV
VL - 17
CY - New York, New York
PB - Guilford Publications Inc.
AB - This article describes the challenges of using data to plan and fund HIV/AIDS care services for underserved populations under the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act. It also outlines methods that have been developed by the Health Resources and Services Administration of the U.S. Department of Health and Human Services to assist community planning groups in using data to decide how to target limited federal resources under the CARE Act. Use of CARE Act dollars is guided largely by an array of legislatively identified priority areas, such as targeting of low income HIV-infected individuals who are not in care for their HIV disease. CARE Act program guidance covers the use of epidemiologic HIV and AIDS case data, quantification of unmet need for HIV care, guidance on making objective decisions on priorities for funding within a community planning process, and other instructions on the use of data in making decisions.
SN - 0899-9546
AD - Health Resources and Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Room 7-29, Rockville, MD 20857; chayes@hrsa.gov
U2 - PMID: 16401179.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106430985&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Powers, John H.
T1 - Microbiologic Surrogate End Points in Clinical Trials of Infectious Diseases: Example of Acute Otitis Media Trials.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2005/12/02/Dec2005 Part 2
VL - 25
M3 - Article
SP - 109S
EP - 123S
SN - 02770008
AB - Clinical outcomes that measure how patients feel, function, or survive are the most important and relevant outcomes of therapy in clinical trials and in clinical practice. Surrogate end points, which do not directly measure clinical benefit to the patient, may function as substitutes for clinical end points in clinical trials. Such surrogates are attractive as they may allow measurement of outcomes earlier in time or with a smaller sample size than with clinical outcomes. Microbiologic biomarkers, such as culture results at a specific time after start of therapy, or pharmacodynamic analyses of the effect of drugs on organisms often are proposed as surrogate end points in clinical trials of therapies for infectious diseases. However, evaluation of biomarkers as surrogate end points poses distinct challenges, and only a few biomarkers have been useful replacements for clinical end points. Evaluation of biomarkers as potential surrogate end points first requires an understanding of the differences among measurements of the cause of a disease, risk factors for outcome, and measurements of treatment effects. We will discuss the definitions of clinical and surrogate end points and the reasons why surrogate end points may not predict the true clinical benefit of therapies. We will use the example of the biomarker of microbiologic outcomes from tympanocenteses performed during therapy as the sole measure of clinical effectiveness in clinical trials of acute otitis media to illustrate the challenges in evaluating biomarkers as surrogate end points. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACUTE otitis media
KW - CLINICAL trials
KW - COMMUNICABLE diseases
KW - DISEASES -- Risk factors
KW - SAMPLE size (Statistics)
KW - BIOCHEMICAL markers
KW - acute otitis media
KW - surrogate end points
KW - tympanocentesis
N1 - Accession Number: 19353441; Powers, John H. 1,2; Email Address: POWERSJOH@cder.fda.gov; Affiliation: 1: Office of Antimicrobial Products, Center for Drug Evaluation and Research, United Stales Food and Drug Administration, Rockville, Maryland 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Source Info: Dec2005 Part 2, Vol. 25, p109S; Subject Term: ACUTE otitis media; Subject Term: CLINICAL trials; Subject Term: COMMUNICABLE diseases; Subject Term: DISEASES -- Risk factors; Subject Term: SAMPLE size (Statistics); Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: acute otitis media; Author-Supplied Keyword: surrogate end points; Author-Supplied Keyword: tympanocentesis; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Illustrations: 1 Graph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19353441&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murashov, Vladimir V.
AU - Demchuk, Eugene
T1 - Surface sites and unrelaxed surface energies of tetrahedral silica polymorphs and silicate
JO - Surface Science
JF - Surface Science
Y1 - 2005/12/05/
VL - 595
IS - 1-3
M3 - Article
SP - 6
EP - 19
SN - 00396028
AB - Abstract: Surface properties of respirable silica, which represents a major occupational safety concern, were investigated computationally, and a model for quantitative characterization of crystalline silica surface sites was developed. It was found that the surface energy of crystalline solids, such as silica and silicates, can be calculated as a product of the surface site density and site energy. The energies of sites formed by faceting tetrahedral silica polymorphs and aluminosilicate were determined by parametric fitting ab initio surface energies to site densities. Boltzmann’s statistics was used to describe the distribution of faces as an exponential function of unrelaxed surface energy in the comminuted crystalline solids. Using these findings, crystallographic face distributions on fractured quartz, coesite, tridymite, and cristobalite were derived and average silanol hydroxyl densities in fractured particulate of these materials were estimated as 0.070, 0.059, 0.058, and 0.055Å−2, respectively. The proposed method of quantitative characterization of the surface bridges the gap between microscopic simulations and measurable observables, such as cytotoxicity of respirable silica. [Copyright &y& Elsevier]
AB - Copyright of Surface Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICON
KW - SILICON compounds
KW - MATTER -- Properties
KW - SURFACE chemistry
KW - Cleavage
KW - Density functional calculations
KW - Faceting
KW - Silicates
KW - Surface distribution
KW - Surface energy
KW - Surface sites
KW - Thermodynamics
N1 - Accession Number: 18980676; Murashov, Vladimir V. 1; Email Address: vmurashov@cdc.gov Demchuk, Eugene 1,2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA 2: School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Source Info: Dec2005, Vol. 595 Issue 1-3, p6; Subject Term: SILICON; Subject Term: SILICON compounds; Subject Term: MATTER -- Properties; Subject Term: SURFACE chemistry; Author-Supplied Keyword: Cleavage; Author-Supplied Keyword: Density functional calculations; Author-Supplied Keyword: Faceting; Author-Supplied Keyword: Silicates; Author-Supplied Keyword: Surface distribution; Author-Supplied Keyword: Surface energy; Author-Supplied Keyword: Surface sites; Author-Supplied Keyword: Thermodynamics; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.susc.2005.07.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18980676&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones-Trower, Agnes
AU - Garcia, Alonzo
AU - Meseda, Clement A.
AU - He, Yong
AU - Weiss, Carol
AU - Kumar, Arunima
AU - Weir, Jerry P.
AU - Merchlinsky, Michael
T1 - Identification and preliminary characterization of vaccinia virus (Dryvax) antigens recognized by vaccinia immune globulin
JO - Virology
JF - Virology
Y1 - 2005/12/05/
VL - 343
IS - 1
M3 - Article
SP - 128
EP - 140
SN - 00426822
AB - Abstract: Using vaccinia immune globulin (VIG), a high-titer antibody preparation from immunized subjects, we demonstrate that the humoral immune response in humans is directed against numerous antigens in the Dryvax vaccine strain. Western blot and immunoprecipitation analyses revealed highly antigenic proteins associated with both the extracellular enveloped virus and intracellular mature virus forms. The modified vaccinia virus Ankara (MVA), a new generation smallpox vaccine that is attenuated for replication in humans, expresses most, but not all, of the major vaccinia antigens recognized by antibodies in VIG, lacking the highly antigenic protein corresponding to the A-type inclusion body protein. Since new-generation smallpox vaccines such as MVA will require extensive comparison to traditional smallpox vaccines in animal models of immunogenicity and protection, we compared the vaccinia virus antigens recognized by VIG to those recognized by sera from Dryvax and MVA immunized mice. The humoral immune response in immunized mice is qualitatively similar to that in humans. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATTLE -- Virus diseases
KW - IMMUNOGLOBULINS
KW - VACCINATION
KW - SMALLPOX vaccine
KW - Dryvax
KW - Humoral response
KW - Inclusion body protein
KW - MVA
KW - Vaccinia
KW - VIG
N1 - Accession Number: 19008944; Jones-Trower, Agnes 1 Garcia, Alonzo 1 Meseda, Clement A. 1 He, Yong 1 Weiss, Carol 1 Kumar, Arunima 1 Weir, Jerry P. 1 Merchlinsky, Michael; Email Address: merchlinsky@cber.fda.gov; Affiliation: 1: Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-457, 1401 Rockville Pike, Rockville, MD 20852-1448, USA; Source Info: Dec2005, Vol. 343 Issue 1, p128; Subject Term: CATTLE -- Virus diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: VACCINATION; Subject Term: SMALLPOX vaccine; Author-Supplied Keyword: Dryvax; Author-Supplied Keyword: Humoral response; Author-Supplied Keyword: Inclusion body protein; Author-Supplied Keyword: MVA; Author-Supplied Keyword: Vaccinia; Author-Supplied Keyword: VIG; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.virol.2005.08.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19008944&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Izurieta, Hector S.
AU - Haber, Penina
AU - Wise, Robert P.
AU - Iskander, John
AU - Pratt, Douglas
AU - Mink, ChrisAnna
AU - Chang, Soju
AU - Braun, M. Miles
AU - Ball, Robert
T1 - Adverse Events Reported Following Live, Cold-Adapted, Intranasal Influenza Vaccine.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2005/12/07/
VL - 294
IS - 21
M3 - Article
SP - 2720
EP - 2725
SN - 00987484
AB - Context: In June 2003, the US Food and Drug Administration licensed a trivalent live, attenuated influenza vaccine (LAIV-T) for intranasal administration to healthy persons 5 to 49 years of age. Although prelicensure testing involved 20 228 vaccinees, clinical trials were not of sufficient size to detect rare adverse events reliably. Objective: To identify adverse events reported following LAIV-T administration after licensure. Design, Setting, and Participants: All adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) during the 2003-2004 and the 2004-2005 influenza seasons. Main Outcome Measures: Numbers and proportions of reported adverse events and reporting rates of adverse events per 100 000 vaccinees. Results: Approximately 2 500 000 persons received LAIV-T during the first 2 postlicensure seasons. As of August 16, 2005, VAERS received 460 adverse event reports for vaccinations received from August 2003 through July 2005. No fatalities were reported. There were 7 reports of possible anaphylaxis, 2 reports of Guillain-Barré syndrome, 1 report of Bell palsy, and 8 reports of asthma exacerbation among individuals with a prior asthma history. Events in individuals for whom the vaccine was not indicated accounted for 73 reports (16%). Conclusions: Reports to VAERS in the first 2 seasons of LAIV-T use did not identify any unexpected serious risks with this vaccine when used according to approved indications. Like many vaccines and other medical products, LAIV-T may rarely cause anaphylaxis. Secondary transmission of the vaccine virus merits further investigation. Reports of asthma exacerbations in vaccinees with prior asthma history highlight the risks of vaccine use inconsistent with approved labeling. [ABSTRACT FROM AUTHOR]
AB - Copyright of JAMA: Journal of the American Medical Association is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA viruses
KW - COMMUNICABLE diseases -- Prevention
KW - PREVENTIVE medicine
KW - VACCINATION
KW - RESEARCH
KW - MEDICAL research
KW - Anaphylaxis
KW - Asthma
KW - Drug Reaction, Adverse
KW - Influenza Vaccines
N1 - Accession Number: 19091003; Izurieta, Hector S. 1 Haber, Penina 1 Wise, Robert P. 1 Iskander, John 1 Pratt, Douglas 1 Mink, ChrisAnna 1 Chang, Soju 1 Braun, M. Miles 1 Ball, Robert 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md (Drs Izurieta, Wise, Pratt, Mink, Chang, Braun, and Ball); and National Immunization Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention, Atlanta, Ga (Ms Haber and Dr Iskander).; Source Info: 12/7/2005, Vol. 294 Issue 21, p2720; Subject Term: INFLUENZA viruses; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: PREVENTIVE medicine; Subject Term: VACCINATION; Subject Term: RESEARCH; Subject Term: MEDICAL research; Author-Supplied Keyword: Anaphylaxis; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Drug Reaction, Adverse; Author-Supplied Keyword: Influenza Vaccines; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19091003&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106234423
T1 - Adverse events reported following live, cold-adapted, intranasal influenza vaccine.
AU - Izurieta HS
AU - Haber P
AU - Wise RP
AU - Iskander J
AU - Pratt D
AU - Mink C
AU - Chang S
AU - Braun MM
AU - Ball R
AU - Izurieta, Hector S
AU - Haber, Penina
AU - Wise, Robert P
AU - Iskander, John
AU - Pratt, Douglas
AU - Mink, ChrisAnna
AU - Chang, Soju
AU - Braun, M Miles
AU - Ball, Robert
Y1 - 2005/12/07/
N1 - Accession Number: 106234423. Language: English. Entry Date: 20070209. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Commentary: Neuzil KM, Griffin MR, Neuzil Kathleen M, Griffin Marie R. Vaccine safety--achieving the proper balance. (JAMA) 12/7/2005; 294 (21): 2763-2765. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Centers for Disease Control and Prevention and the Food and Drug Administration. NLM UID: 7501160.
KW - Administration, Inhalation
KW - Influenza Vaccine -- Administration and Dosage
KW - Influenza Vaccine -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Anaphylaxis -- Epidemiology
KW - Child
KW - Child, Preschool
KW - Funding Source
KW - Influenza -- Transmission
KW - Middle Age
KW - Nervous System Diseases -- Epidemiology
KW - Record Review
KW - Respiratory Tract Diseases -- Epidemiology
KW - Retrospective Design
KW - Human
SP - 2720
EP - 2725
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 294
IS - 21
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: In June 2003, the US Food and Drug Administration licensed a trivalent live, attenuated influenza vaccine (LAIV-T) for intranasal administration to healthy persons 5 to 49 years of age. Although prelicensure testing involved 20 228 vaccinees, clinical trials were not of sufficient size to detect rare adverse events reliably.Objective: To identify adverse events reported following LAIV-T administration after licensure.Design, Setting, and Participants: All adverse events reported to the US Vaccine Adverse Event Reporting System (VAERS) during the 2003-2004 and the 2004-2005 influenza seasons.Main Outcome Measures: Numbers and proportions of reported adverse events and reporting rates of adverse events per 100,000 vaccinees.Results: Approximately 2,500,000 persons received LAIV-T during the first 2 postlicensure seasons. As of August 16, 2005, VAERS received 460 adverse event reports for vaccinations received from August 2003 through July 2005. No fatalities were reported. There were 7 reports of possible anaphylaxis, 2 reports of Guillain-Barré syndrome, 1 report of Bell palsy, and 8 reports of asthma exacerbation among individuals with a prior asthma history. Events in individuals for whom the vaccine was not indicated accounted for 73 reports (16%).Conclusions: Reports to VAERS in the first 2 seasons of LAIV-T use did not identify any unexpected serious risks with this vaccine when used according to approved indications. Like many vaccines and other medical products, LAIV-T may rarely cause anaphylaxis. Secondary transmission of the vaccine virus merits further investigation. Reports of asthma exacerbations in vaccinees with prior asthma history highlight the risks of vaccine use inconsistent with approved labeling.
SN - 0098-7484
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md 20852-1448, USA
AD - Vaccine Safety Branch, Division of epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Second Floor, Suite 200S, HFM-222, Rockville, MD 20852-1448; hector.izurieta@fda.hhs.gov
U2 - PMID: 16333007.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106234423&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Westenberger, Benjamin J.
AU - Ellison, Christopher D.
AU - Fussner, Andrew S.
AU - Jenney, Susan
AU - Kolinski, Richard E.
AU - Lipe, Terra G.
AU - Lyon, Robbe C.
AU - Moore, Terry W.
AU - Revelle, Larry K.
AU - Smith, Anjanette P.
AU - Spencer, John A.
AU - Story, Kimberly D.
AU - Toler, Duckhee Y.
AU - Wokovich, Anna M.
AU - Buhse, Lucinda F.
T1 - Quality assessment of internet pharmaceutical products using traditional and non-traditional analytical techniques
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2005/12/08/
VL - 306
IS - 1/2
M3 - Article
SP - 56
EP - 70
SN - 03785173
AB - Abstract: This work investigated the use of non-traditional analytical methods to evaluate the quality of a variety of pharmaceutical products purchased via internet sites from foreign sources and compared the results with those obtained from conventional quality assurance methods. Traditional analytical techniques employing HPLC for potency, content uniformity, chromatographic purity and drug release profiles were used to evaluate the quality of five selected drug products (fluoxetine hydrochloride, levothyroxine sodium, metformin hydrochloride, phenytoin sodium, and warfarin sodium). Non-traditional techniques, such as near infrared spectroscopy (NIR), NIR imaging and thermogravimetric analysis (TGA), were employed to verify the results and investigate their potential as alternative testing methods. Two of 20 samples failed USP monographs for quality attributes. The additional analytical methods found 11 of 20 samples had different formulations when compared to the U.S. product. Seven of the 20 samples arrived in questionable containers, and 19 of 20 had incomplete labeling. Only 1 of the 20 samples had final packaging similar to the U.S. products. The non-traditional techniques complemented the traditional techniques used and highlighted additional quality issues for the products tested. For example, these methods detected suspect manufacturing issues (such as blending), which were not evident from traditional testing alone. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITY of products
KW - DRUGS
KW - INTERNET marketing
KW - ANALYTICAL chemistry
KW - INFRARED spectroscopy
KW - Analytical chemistry
KW - Chemometrics
KW - Chromatography
KW - coefficient of variance ( CV )
KW - Dissolution
KW - Food and Drug Administration ( FDA )
KW - Image analysis
KW - Near infrared spectroscopy
KW - near infrared spectroscopy ( NIR )
KW - partial least squares ( PLS )
KW - relative standard deviation ( R.S.D. )
KW - revolutions per minute ( RPM )
KW - Thermal analysis
N1 - Accession Number: 19059817; Westenberger, Benjamin J. 1; Email Address: westenberger@cder.fda.gov Ellison, Christopher D. 2 Fussner, Andrew S. 1 Jenney, Susan 3 Kolinski, Richard E. 1 Lipe, Terra G. 1 Lyon, Robbe C. 2 Moore, Terry W. 1 Revelle, Larry K. 1 Smith, Anjanette P. 1 Spencer, John A. 1 Story, Kimberly D. 1 Toler, Duckhee Y. 1 Wokovich, Anna M. 1 Buhse, Lucinda F. 1; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, St. Louis, MO 63101, USA 2: Food and Drug Administration, Division of Product Quality Research, Silver Spring, MD, USA 3: Food and Drug Administration, Division of Pharmaceutical Analysis, Silver Spring, MD, USA; Source Info: Dec2005, Vol. 306 Issue 1/2, p56; Subject Term: QUALITY of products; Subject Term: DRUGS; Subject Term: INTERNET marketing; Subject Term: ANALYTICAL chemistry; Subject Term: INFRARED spectroscopy; Author-Supplied Keyword: Analytical chemistry; Author-Supplied Keyword: Chemometrics; Author-Supplied Keyword: Chromatography; Author-Supplied Keyword: coefficient of variance ( CV ); Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Food and Drug Administration ( FDA ); Author-Supplied Keyword: Image analysis; Author-Supplied Keyword: Near infrared spectroscopy; Author-Supplied Keyword: near infrared spectroscopy ( NIR ); Author-Supplied Keyword: partial least squares ( PLS ); Author-Supplied Keyword: relative standard deviation ( R.S.D. ); Author-Supplied Keyword: revolutions per minute ( RPM ); Author-Supplied Keyword: Thermal analysis; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 454111 Electronic Shopping; NAICS/Industry Codes: 454110 Electronic shopping and mail-order houses; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.ijpharm.2005.08.027
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106274907
T1 - Hormone therapy for the prevention of chronic conditions in postmenopausal women.
AU - Guirguis-Blake J
Y1 - 2005/12/15/
N1 - Accession Number: 106274907. Language: English. Entry Date: 20070427. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Chronic Disease -- Risk Factors
KW - Hormone Replacement Therapy
KW - Aged
KW - Cardiovascular Diseases -- Prevention and Control
KW - Education, Continuing (Credit)
KW - Female
KW - Hormone Replacement Therapy -- Adverse Effects
KW - Osteoporosis -- Prevention and Control
SP - 2520
EP - 2429
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 72
IS - 12
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Preventive Services Task Force Center for Primary Care, Prevention, and Clinical Partnership, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 16370410.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106274907&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106394300
T1 - Correlates of oxidative stress and free-radical activity in serum from asymptomatic shipyard welders.
AU - Han SG
AU - Kim Y
AU - Kashon ML
AU - Pack DL
AU - Castranova V
AU - Vallyathan V
Y1 - 2005/12/15/
N1 - Accession Number: 106394300. Language: English. Entry Date: 20060210. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9421642.
KW - Free Radicals -- Adverse Effects
KW - Free Radicals -- Blood
KW - Occupational Diseases -- Blood
KW - Oxidative Stress
KW - Adult
KW - Analysis of Variance
KW - Blood Proteins
KW - Case Control Studies
KW - Confidence Intervals
KW - Data Analysis Software
KW - Extraction and Processing Industry
KW - Glutathione -- Blood
KW - Lead -- Blood
KW - Male
KW - Manganese -- Blood
KW - Reactive Oxygen Species -- Blood
KW - Serum Albumin -- Blood
KW - Human
SP - 1541
EP - 1548
JO - American Journal of Respiratory & Critical Care Medicine
JF - American Journal of Respiratory & Critical Care Medicine
JA - AM J RESPIR CRIT CARE MED
VL - 172
IS - 12
CY - New York, New York
PB - American Thoracic Society
AB - Rationale: Oxidative stress is believed to play a key role in the development of welding-induced disease.Objectives: This study investigated the effects of welding fume exposure on correlates of oxidative stress in the serum of asymptomatic shipyard welders.Methods: Blood samples from 197 male welders and 150 unexposed male office workers were analyzed for manganese and lead. Serum was assayed for protein, albumin, total antioxidant status (TAS), manganese superoxide dismutase (Mn-SOD), aconitase, glutathione peroxidase (GPx), heat shock protein 70, isoprostane, and reactive oxygen species, using electron spin resonance and chemiluminescence. Comparisons between welders and control subjects on biomarkers of oxidative stress were made, and evaluated for the effects of age and smoking. Associations between blood levels of manganese and lead and biomarkers were also explored.Results: Welding was associated with increases in serum protein, GPx, aconitase, TAS, and isoprostane levels compared with control subjects. These group differences were not altered by age or smoking. In welders and control subjects, age was significantly associated with changes in albumin, TAS, chemiluminescence, GPx, and Mn-SOD. In welders and control subjects, smoking resulted in a decrease in GPx, and in a significant interaction between smoking and chemiluminescence. There were significant correlations between manganese levels in welders' blood and chemiluminescence, GPx, and Mn-SOD, and between lead levels and albumin, TAS, GPx, and Mn-SOD.Conclusions: These results document that exposure to welding can cause changes in serum biomarkers of oxidative stress that may be valuable in clinical monitoring of disease development and in assessing whether further reduction of worker exposures is needed.
SN - 1073-449X
AD - Pathology and Physiology Research Branch and Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia, Morgantown, WV
U2 - PMID: 16166614.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Xu, Peng
AU - Kujundzic, Elmira
AU - Peccia, Jordan
AU - Schafer, Millie P.
AU - Moss, Gene
AU - Hernandez, Mark
AU - Miller, Shelly L.
T1 - Impact of Environmental Factors on Efficacy of Upper-Room Air Ultraviolet Germicidal Irradiation for Inactivating Airborne Mycobacteria.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2005/12/15/
VL - 39
IS - 24
M3 - Article
SP - 9656
EP - 9664
SN - 0013936X
AB - This study evaluated the efficacy of an upper-room air ultraviolet germicidal irradiation (UVGI) system for inactivating airborne bacteria, which irradiates the upper part of a room while minimizing radiation exposure to persons in the lower part of the room. A full-scale test room (87 m3), fitted with a UVGI system consisting of 9 louvered wall and ceiling fixtures (504 W all lamps operating) was operated at 24 and 34 °C, between 25 and 90% relative humidity, and at three ventilation rates. Mycobacterium parafortuitum cells were aerosolized into the room such that their numbers and physiologic state were comparable both with and without the UVGI system operating. Airborne bacteria were collected in duplicate using liquid impingers and quantified with direct epifluorescent microscopy and standard culturing assay. Performance of the UVGI system degraded significantly when the relative humidity was increased from 50% to 75-90% RH, the horizontal UV fluence rate distribution was skewed to one side compared to being evenly dispersed, and the room air temperature was stratified from hot at the ceiling to cold at the floor. The inactivation rate increased linearly with effective UV fluence rate up to 5 μW cm-2; an increase in the fluence rate above this level did not yield a proportional increase in inactivation rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacteria
KW - Air -- Purification
KW - Humidity
KW - Bacteria
KW - Actinomycetales
KW - Germicidal lamps
KW - Direct epifluorescent filter technique
KW - Ultraviolet lamps
N1 - Accession Number: 19526028; Xu, Peng 1,2; Kujundzic, Elmira 1; Peccia, Jordan 1,3; Schafer, Millie P. 4; Moss, Gene 5; Hernandez, Mark 1; Miller, Shelly L. 6; Email Address: shelly.miller@colorado.edu; Affiliations: 1: Department of Civil, Environmental, and Architectural Engineering, 428 UCB, University of Colorado, Boulder, Colorado 80309-0428.; 2: Building Technologies, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 90-3111, Berkeley, CA, 94720.; 3: Environmental Engineering Program, Yale University, P0 Box 208286, New Haven, CT 06520-8286.; 4: The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Public Health Services, U. S. Department of Health and Human Services, 4676 Columbia Parkway, MS R-3, Cincinnati, Ohio 45226-1099.; 5: Corning Inc., SP-AR-01-1, AR183F, Corning, NY 14831.; 6: Department of Mechanical Engineering, 427 UCB, University of Colorado, Boulder, Colorado 80309-0427.; Issue Info: 12/15/2005, Vol. 39 Issue 24, p9656; Thesaurus Term: Mycobacteria; Thesaurus Term: Air -- Purification; Thesaurus Term: Humidity; Thesaurus Term: Bacteria; Thesaurus Term: Actinomycetales; Subject Term: Germicidal lamps; Subject Term: Direct epifluorescent filter technique; Subject Term: Ultraviolet lamps; NAICS/Industry Codes: 335120 Lighting fixture manufacturing; NAICS/Industry Codes: 335129 Other Lighting Equipment Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xin, K.-Q.
AU - Jounai, N.
AU - Someya, K.
AU - Honma, K.
AU - Mizuguchi, H.
AU - Naganawa, S.
AU - Kitamura, K.
AU - Hayakawa, T.
AU - Saha, S.
AU - Takeshita, F.
AU - Okuda, K.
AU - Honda, M.
AU - Klinman, D. M.
T1 - Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV.
JO - Gene Therapy
JF - Gene Therapy
Y1 - 2005/12/15/
VL - 12
IS - 24
M3 - Article
SP - 1769
EP - 1777
PB - Nature Publishing Group
SN - 09697128
AB - Immunization involving a DNA vaccine prime followed by an adenovirus type 5 (Ad5) boost elicited a protective immune response against SHIV challenge in monkeys. However, the hepatocellular tropism of Ad5 limits the safety of this viral vector. This study examines the safety and immunogenicity of a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) in BALB/c mice and rhesus monkeys. This novel Ad5/35 vector showed minimal hepatotoxicity after intramuscular administration with the novel Ad5/35 vector. In addition, an Ad5/35 vector expressing HIV Env gp160 protein (Ad5/35-HIV) generated strong HIV-specific immune responses in both animal models. Priming with a DNA vaccine followed by Ad5/35-HIV boosting yielded protection against a gp160-expressing vaccinia virus challenge in BALB/c mice. The Ad5/35-HIV vector was significantly less susceptible to the pre-existing Ad5 immunity than a comparable Ad5 vector. These findings indicate that an Ad5/35 vector-based HIV vaccine may be of considerable value for clinical use.Gene Therapy (2005) 12, 1769–1777. doi:10.1038/sj.gt.3302590; published online 4 August 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Gene Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - PLASMIDS
KW - ADENOVIRUSES
KW - IMMUNITY
KW - HIV (Viruses)
KW - MICE as laboratory animals
KW - Ad5/35 vector
KW - animal model
KW - HIV
KW - immune response
KW - vaccine
N1 - Accession Number: 19071358; Xin, K.-Q. 1 Jounai, N. 1 Someya, K. 2 Honma, K. 3 Mizuguchi, H. 4 Naganawa, S. 5 Kitamura, K. 5 Hayakawa, T. 4 Saha, S. 1 Takeshita, F. 1 Okuda, K. 1,3 Honda, M. 2 Klinman, D. M. 6; Affiliation: 1: Department of Molecular Biodefense Research, Yokohama City University, Graduate School of Medicine, Yokohama, Japan 2: AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan 3: Department of Microbiology, Tokyo Dental College, Chiba, Japan 4: Laboratory of Gene Transfer and Regulation National Institute of Biomedical Innovation, Osaka, Japan 5: Department of Public Health, Yokohama City University, Graduate School of Medicine, Yokohama, Japan 6: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA; Source Info: Dec2005, Vol. 12 Issue 24, p1769; Subject Term: VACCINATION; Subject Term: PLASMIDS; Subject Term: ADENOVIRUSES; Subject Term: IMMUNITY; Subject Term: HIV (Viruses); Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Ad5/35 vector; Author-Supplied Keyword: animal model; Author-Supplied Keyword: HIV; Author-Supplied Keyword: immune response; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1038/sj.gt.3302590
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gebo, Kelly A.
AU - Fleishman, John A.
AU - Moore, Richard D.
T1 - Hospitalizations for Metabolic Conditions, Opportunistic Infections, and Injection Drug Use Among HIV Patients Trends Between 7996 and 2000 in 72 States.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/12/15/
VL - 40
IS - 5
M3 - Article
SP - 609
EP - 616
SN - 15254135
AB - The article focuses on the hospitalizations for metabolic conditions, opportunistic infections and injection drug use among HIV patients in 72 states. Rapid changes in HIV epidemiology and highly active antiretroviral therapy (HAART) result in inpatient utilization. The objectives is to examine trends in inpatient diagnoses and mortality in HIV patients. Each hospitalization was classified as an opportunistic illness, complication of injection drug use, liver-related complication, and diabetes.
KW - AIDS (Disease) -- Prevention
KW - HIV infections
KW - OPPORTUNISTIC infections
KW - HIV-positive persons
KW - HOSPITAL care
KW - DIABETES -- Complications
KW - ANTIVIRAL agents
KW - PUBLIC health
KW - highly active antiretroviral therapy
KW - HIV
KW - hospitalization
KW - injection drug use
KW - liver disease
N1 - Accession Number: 19284771; Gebo, Kelly A. 1; Email Address: kgebo@jhmi.edu Fleishman, John A. 2 Moore, Richard D. 1; Affiliation: 1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 2: Agency for Healthcare Research and Quality, Rockville, MD; Source Info: 12/15/2005, Vol. 40 Issue 5, p609; Subject Term: AIDS (Disease) -- Prevention; Subject Term: HIV infections; Subject Term: OPPORTUNISTIC infections; Subject Term: HIV-positive persons; Subject Term: HOSPITAL care; Subject Term: DIABETES -- Complications; Subject Term: ANTIVIRAL agents; Subject Term: PUBLIC health; Author-Supplied Keyword: highly active antiretroviral therapy; Author-Supplied Keyword: HIV; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: liver disease; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gebo, Kelly A.
AU - Fleishman, John A.
AU - Moore, Richard D.
T1 - Hospitalizations for Metabolic Conditions, Opportunistic Infections, and Injection Drug Use Among HIV Patients Trends Between 7996 and 2000 in 72 States.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2005/12/15/
VL - 40
IS - 5
M3 - Article
SP - 609
EP - 616
SN - 15254135
AB - The article focuses on the hospitalizations for metabolic conditions, opportunistic infections and injection drug use among HIV patients in 72 states. Rapid changes in HIV epidemiology and highly active antiretroviral therapy (HAART) result in inpatient utilization. The objectives is to examine trends in inpatient diagnoses and mortality in HIV patients. Each hospitalization was classified as an opportunistic illness, complication of injection drug use, liver-related complication, and diabetes.
KW - AIDS (Disease) -- Prevention
KW - HIV infections
KW - OPPORTUNISTIC infections
KW - HIV-positive persons
KW - HOSPITAL care
KW - DIABETES -- Complications
KW - ANTIVIRAL agents
KW - PUBLIC health
KW - highly active antiretroviral therapy
KW - HIV
KW - hospitalization
KW - injection drug use
KW - liver disease
N1 - Accession Number: 19284771; Gebo, Kelly A. 1; Email Address: kgebo@jhmi.edu; Fleishman, John A. 2; Moore, Richard D. 1; Source Information: 12/15/2005, Vol. 40 Issue 5, p609; Subject: AIDS (Disease) -- Prevention; Subject: HIV infections; Subject: OPPORTUNISTIC infections; Subject: HIV-positive persons; Subject: HOSPITAL care; Subject: DIABETES -- Complications; Subject: ANTIVIRAL agents; Subject: PUBLIC health; Author-Supplied Keyword: highly active antiretroviral therapy; Author-Supplied Keyword: HIV; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: liver disease; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Laassri, Majid
AU - Lottenbach, Kathleen
AU - Belshe, Robert
AU - Wolff, Mark
AU - Rennels, Margaret
AU - Plotkin, Stanley
AU - Chumakov, Konstantin
T1 - Effect of Different Vaccination Schedules on Excretion of Oral Poliovirus Vaccine Strains.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2005/12/15/
VL - 192
IS - 12
M3 - Article
SP - 2092
EP - 2098
SN - 00221899
AB - Inactivated poliovirus vaccine (IPV) is believed to induce significantly lower mucosal immunity than oral poliovirus vaccine (OPV). Most of the data supporting this were generated before enhanced IPV (eIPV) was introduced. Excretion of poliovirus by OPV recipients can be used to assess intestinal immunity. We studied polymerase chain reaction amplification of viral complementary DNA from the stool of children vaccinated with either OPV alone or eIPV. Of first-time OPV recipients, 92% excreted virus after 1 week, and 81% excreted virus after 3 weeks. Prior vaccination with OPV reduced the number to 22% and shortened the duration of virus excretion (to 5% after 3 weeks). Two doses of IPV reduced the number of poliovirus-positive 1-week samples (to 76%), the duration of shedding (to 37% at 3 weeks), and the quantity of excreted virus. This suggests that IPV-vaccinated communities are partially protected from the spread of poliovirus. Further enhancement of IPV potency may lead to even higher levels of mucosal immunity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORAL poliomyelitis vaccine
KW - VIRAL vaccines
KW - POLIOVIRUS
KW - VACCINATION
KW - POLYMERASE chain reaction
KW - IMMUNITY
N1 - Accession Number: 19007804; Laassri, Majid 1 Lottenbach, Kathleen 2 Belshe, Robert 2 Wolff, Mark 3 Rennels, Margaret 4 Plotkin, Stanley 5,6 Chumakov, Konstantin 1; Email Address: chumakov@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville. 2: Saint Louis University, St. Louis, Missouri. 3: EMMES Corporation, Rockville. 4: University of Maryland School of Medicine, Baltimore, Maryland. 5: University of Pennsylvania, Philadelphia. 6: Sanofi Pasteur, Doylestown, Pennsylvania.; Source Info: 12/15/2005, Vol. 192 Issue 12, p2092; Subject Term: ORAL poliomyelitis vaccine; Subject Term: VIRAL vaccines; Subject Term: POLIOVIRUS; Subject Term: VACCINATION; Subject Term: POLYMERASE chain reaction; Subject Term: IMMUNITY; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106351496
T1 - Effect of different vaccination schedules on excretion of oral poliovirus vaccine strains.
AU - Laassri M
AU - Lottenbach K
AU - Belshe R
AU - Wolff M
AU - Rennels M
AU - Plotkin S
AU - Chumakov K
Y1 - 2005/12/15/
N1 - Accession Number: 106351496. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Commentary: Hull HF, Minor PD. When can we stop using oral poliovirus vaccine? (J INFECT DIS) 12/15/2005; 192 (12): 2033-2035. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Defense Advanced Research Projects Agency (grant); National Institute of Allergy and Infectious Diseases (contracts NO1-AI-45250, NO1-AI-45251). NLM UID: 0413675.
KW - Immunization Schedule
KW - Poliovirus Vaccine, Oral -- Administration and Dosage
KW - Clinical Trials
KW - Enteroviruses
KW - Enteroviruses -- Classification
KW - Funding Source
KW - Human
KW - Infant
KW - Poliovirus Vaccine, Oral -- Immunology
KW - Polymerase Chain Reaction
KW - Random Assignment
SP - 2092
EP - 2098
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 192
IS - 12
PB - Oxford University Press / USA
AB - Inactivated poliovirus vaccine (IPV) is believed to induce significantly lower mucosal immunity than oral poliovirus vaccine (OPV). Most of the data supporting this were generated before enhanced IPV (eIPV) was introduced. Excretion of poliovirus by OPV recipients can be used to assess intestinal immunity. We studied polymerase chain reaction amplification of viral complementary DNA from the stool of children vaccinated with either OPV alone or eIPV. Of first-time OPV recipients, 92% excreted virus after 1 week, and 81% excreted virus after 3 weeks. Prior vaccination with OPV reduced the number to 22% and shortened the duration of virus excretion (to 5% after 3 weeks). Two doses of IPV reduced the number of poliovirus-positive 1-week samples (to 76%), the duration of shedding (to 37% at 3 weeks), and the quantity of excreted virus. This suggests that IPV-vaccinated communities are partially protected from the spread of poliovirus. Further enhancement of IPV potency may lead to even higher levels of mucosal immunity. Copyright © 2005 Infectious Diseases Society of America
SN - 0022-1899
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Baltimore, Maryland, USA.
U2 - PMID: 16288372.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Eckert, Dawn
AU - Williams, Ollie
AU - Meseda, Clement A.
AU - Merchlinsky, Michael
T1 - Vaccinia Virus Nicking-Joining Enzyme Is Encoded by K4L (VACWR035).
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2005/12/15/
VL - 79
IS - 24
M3 - Article
SP - 15084
EP - 15090
SN - 0022538X
AB - Vaccinia virus encodes an enzyme with DNA modifying activity that cleaves and inefficiently cross-links cruciformic DNA. This enzyme is contained within the virion, expressed at late times postinfection, and processes DNA in an energy-independent, Mg2+ ion-independent manner. Viral nuclease activity was measured in extracts from cells infected with well-defined viral mutants. Since some viral extracts lacked nuclease activity, the gene encoding the activity was postulated to be one of the open reading frames absent in the viruses lacking activity. Inducible expression of each candidate open reading frame revealed that only the gene VACWR035, or K4L, was required for nuclease activity. A recombinant virus missing only the open reading frame for K4L lacked nuclease activity. Extracts from a recombinant virus expressing K4L linked to a FLAG polypeptide were able to cleave and cross-link cruciformic DNA. There were no significant differences between the virus lacking K4L and wild-type vaccinia virus WR with respect to infectivity, growth characteristics, or processing of viral replicative intermediate DNA, including both telomeric and cross-linked forms. Purification of the K4L FLAG polypeptide expressed in bacteria yielded protein containing nicking-joining activity, implying that K4L is the only vaccinia virus protein required for the nicking-joining enzymatic activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINIA
KW - CATTLE -- Virus diseases
KW - POXVIRUS diseases
KW - VIRUSES
KW - GENETIC vectors
KW - MICROORGANISMS
KW - RECOMBINANT viruses
KW - VIROLOGY
N1 - Accession Number: 19375113; Eckert, Dawn 1 Williams, Ollie 1 Meseda, Clement A. 1 Merchlinsky, Michael 1; Email Address: merchlinsky@cber.fda.gov; Affiliation: 1: Laboratoty of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 12/15/2005, Vol. 79 Issue 24, p15084; Subject Term: VACCINIA; Subject Term: CATTLE -- Virus diseases; Subject Term: POXVIRUS diseases; Subject Term: VIRUSES; Subject Term: GENETIC vectors; Subject Term: MICROORGANISMS; Subject Term: RECOMBINANT viruses; Subject Term: VIROLOGY; Number of Pages: 7p; Illustrations: 6 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1128/JVI.79.2415084-15090.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pérez-De La Cruz, V.
AU - González-Cortés, C.
AU - Galván-Arzate, S.
AU - Medina-Campos, O.N.
AU - Pérez-Severiano, F.
AU - Ali, S.F.
AU - Pedraza-ChaverrÍ, J.
AU - Santamaría, A.
T1 - Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington’s disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
JO - Neuroscience
JF - Neuroscience
Y1 - 2005/12/15/
VL - 135
IS - 2
M3 - Article
SP - 463
EP - 474
SN - 03064522
AB - Abstract: Oxidative/nitrosative stress is involved in NMDA receptor-mediated excitotoxic brain damage produced by the glutamate analog quinolinic acid. The purpose of this work was to study a possible role of peroxynitrite, a reactive oxygen/nitrogen species, in the course of excitotoxic events evoked by quinolinic acid in the brain. The effects of Fe(TPPS) (5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)), an iron porphyrinate and putative peroxynitrite decomposition catalyst, were tested on lipid peroxidation and mitochondrial function in brain synaptic vesicles exposed to quinolinic acid, as well as on peroxynitrite formation, nitric oxide synthase and superoxide dismutase activities, lipid peroxidation, caspase-3-like activation, DNA fragmentation, and GABA levels in striatal tissue from rats lesioned by quinolinic acid. Circling behavior was also evaluated. Increasing concentrations of Fe(TPPS) reduced lipid peroxidation and mitochondrial dysfunction induced by quinolinic acid (100μM) in synaptic vesicles in a concentration-dependent manner (10–800μM). In addition, Fe(TPPS) (10mg/kg, i.p.) administered 2 h before the striatal lesions, prevented the formation of peroxynitrite, the increased nitric oxide synthase activity, the decreased superoxide dismutase activity and the increased lipid peroxidation induced by quinolinic acid (240nmol/μl) 120 min after the toxin infusion. Enhanced caspase-3-like activity and DNA fragmentation were also reduced by the porphyrinate 24 h after the injection of the excitotoxin. Circling behavior from quinolinic acid-treated rats was abolished by Fe(TPPS) six days after quinolinic acid injection, while the striatal levels of GABA, measured one day later, were partially recovered. The protective effects that Fe(TPPS) exerted on quinolinic acid-induced lipid peroxidation and mitochondrial dysfunction in synaptic vesicles suggest a primary action of the porphyrinate as an antioxidant molecule. In vivo findings suggest that the early production of peroxynitrite, altogether with the enhanced risk of superoxide anion (O2 · −) and nitric oxide formation (its precursors) induced by quinolinic acid in the striatum, are attenuated by Fe(TPPS) through a recovery in the basal activities of nitric oxide synthase and superoxide dismutase. The porphyrinate-mediated reduction in DNA fragmentation simultaneous to the decrease in caspase-3-like activation from quinolinic acid-lesioned rats suggests a prevention in the risk of peroxynitrite-mediated apoptotic events during the course of excitotoxic damage in the striatum. In summary, the protective effects that Fe(TPPS) exhibited both under in vitro and in vivo conditions support an active role of peroxynitrite and its precursors in the pattern of brain damage elicited by excitotoxic events in the experimental model of Huntington’s disease. The neuroprotective mechanisms of Fe(TPPS) are discussed. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRAIN damage
KW - BRAIN diseases
KW - BRAIN -- Wounds & injuries
KW - PATHOLOGICAL psychology
KW - 10
KW - 20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III) ( Fe(TPPS) )
KW - 3-(4
KW - 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide ( MTT )
KW - 3-nitrotyrosine ( 3-NT )
KW - 5
KW - 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III) ( Fe(TPPS) )
KW - 5-dimethylthiazol-2yl)-2
KW - 5-diphenyltetrazolium bromide ( MTT )
KW - analysis of variance ( ANOVA )
KW - apomorphine ( APM )
KW - excitotoxic damage
KW - fluorescent units ( F.U. )
KW - high performance liquid chromatography ( HPLC )
KW - Huntington’s disease ( HD )
KW - inducible nitric oxide synthase ( iNOS )
KW - iron porphyrinate
KW - lipid peroxidation ( LP )
KW - mercaptopropionic acid ( MPA )
KW - Mn(III) tetrakis (4-benzoic acid) porphyrin ( Mn(TBAP) )
KW - N-methyl-d-aspartate receptor ( NMDAr )
KW - neuroprotection
KW - nitric oxide ( NO )
KW - nitric oxide synthase ( NOS )
KW - NMDA receptor
KW - o-phthalaldehyde ( OPA )
KW - oxidative/nitrosative stress
KW - peroxynitrite
KW - peroxynitrite ( ONOO− )
KW - quinolinic acid ( QUIN )
KW - reactive oxygen species ( ROS )
KW - standard error of the mean ( S.E.M. )
KW - superoxide ( O2· − )
KW - superoxide dismutase ( SOD )
KW - tyrosine ( TYR )
N1 - Accession Number: 18319665; Pérez-De La Cruz, V. 1,2 González-Cortés, C. 1,2 Galván-Arzate, S. 3 Medina-Campos, O.N. 2 Pérez-Severiano, F. 3 Ali, S.F. 4 Pedraza-ChaverrÍ, J. 2 Santamaría, A. 1,4; Email Address: absada@yahoo.com; Affiliation: 1: Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México D.F. 14269, Mexico 2: Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico 3: Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México D.F. 14269, Mexico 4: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Dec2005, Vol. 135 Issue 2, p463; Subject Term: BRAIN damage; Subject Term: BRAIN diseases; Subject Term: BRAIN -- Wounds & injuries; Subject Term: PATHOLOGICAL psychology; Author-Supplied Keyword: 10; Author-Supplied Keyword: 20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III) ( Fe(TPPS) ); Author-Supplied Keyword: 3-(4; Author-Supplied Keyword: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: 3-nitrotyrosine ( 3-NT ); Author-Supplied Keyword: 5; Author-Supplied Keyword: 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III) ( Fe(TPPS) ); Author-Supplied Keyword: 5-dimethylthiazol-2yl)-2; Author-Supplied Keyword: 5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: apomorphine ( APM ); Author-Supplied Keyword: excitotoxic damage; Author-Supplied Keyword: fluorescent units ( F.U. ); Author-Supplied Keyword: high performance liquid chromatography ( HPLC ); Author-Supplied Keyword: Huntington’s disease ( HD ); Author-Supplied Keyword: inducible nitric oxide synthase ( iNOS ); Author-Supplied Keyword: iron porphyrinate; Author-Supplied Keyword: lipid peroxidation ( LP ); Author-Supplied Keyword: mercaptopropionic acid ( MPA ); Author-Supplied Keyword: Mn(III) tetrakis (4-benzoic acid) porphyrin ( Mn(TBAP) ); Author-Supplied Keyword: N-methyl-d-aspartate receptor ( NMDAr ); Author-Supplied Keyword: neuroprotection; Author-Supplied Keyword: nitric oxide ( NO ); Author-Supplied Keyword: nitric oxide synthase ( NOS ); Author-Supplied Keyword: NMDA receptor; Author-Supplied Keyword: o-phthalaldehyde ( OPA ); Author-Supplied Keyword: oxidative/nitrosative stress; Author-Supplied Keyword: peroxynitrite; Author-Supplied Keyword: peroxynitrite ( ONOO− ); Author-Supplied Keyword: quinolinic acid ( QUIN ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: standard error of the mean ( S.E.M. ); Author-Supplied Keyword: superoxide ( O2· − ); Author-Supplied Keyword: superoxide dismutase ( SOD ); Author-Supplied Keyword: tyrosine ( TYR ); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.neuroscience.2005.06.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18319665&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yun, Jae Suk
AU - Na, Han Kwang
AU - Park, Ki-Sook
AU - Lee, Yun Hee
AU - Kim, Eun Yeob
AU - Lee, Sung Yong
AU - Kim, Joo-Il
AU - Kang, Ju-Hee
AU - Kim, Dong Sup
AU - Choi, Ki Hwan
T1 - Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity
JO - Toxicology
JF - Toxicology
Y1 - 2005/12/15/
VL - 216
IS - 2/3
M3 - Article
SP - 140
EP - 146
SN - 0300483X
AB - Abstract: The protective effect of an antioxidant, Vitamin E (dl-α-tocopherol, 100mg/kg/day, 8 days p.o. in vivo and 10 and 50μM in vitro) was tested against PCB-induced neurotoxicity. In vivo studies: Microdialysis was used to investigate changes in the striatal extracellular dopamine level and in p-nNOS expression in PCB-treated (Aroclor 1254, 10μg/ml, 2μl/min, 5h; 6μg was infused by microdialysis probe) rats. In vitro studies: Cell viability and levels of p-nNOS expression were observed in PCB-treated (Aroclor 1254, 5μg/ml) immortalized dopaminergic cell line (CATH.a cells). Results: Treatment with PCB: (1) decreased the extracellular dopamine level in rat striatum, (2) increased p-nNOS expression both in rat striatal tissue and in CATH.a cells, (3) reduced the cell viability of, and (4) increased LDH release by CATH.a cells. However, Vitamin E showed a protective effect against PCB-induced toxicity and downregulation of the extracellular dopamine level. These results indicate that Vitamin E may have neuroprotective effects by inhibiting PCB-induced nNOS phosphorylation. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN E
KW - NEUROTOXICOLOGY
KW - ENDOCRINE system
KW - NITRIC-oxide synthases
KW - Aroclor 1254
KW - dl-α-Tocopherol (Vitamin E)
KW - Microdialysis
KW - Neuroprotective
KW - Nitric oxide synthase
N1 - Accession Number: 19061124; Yun, Jae Suk 1 Na, Han Kwang 1 Park, Ki-Sook 1 Lee, Yun Hee 1 Kim, Eun Yeob 1 Lee, Sung Yong 1 Kim, Joo-Il 1 Kang, Ju-Hee 2 Kim, Dong Sup 1 Choi, Ki Hwan 1; Email Address: hyokwa@kfda.go.kr; Affiliation: 1: Division of General Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbundong, Eunpyung-Gu, Seoul 122-704, South Korea 2: Department of Physiology and Biophysics, College of Medicine, Inha University, Incheon 402-751, South Korea; Source Info: Dec2005, Vol. 216 Issue 2/3, p140; Subject Term: VITAMIN E; Subject Term: NEUROTOXICOLOGY; Subject Term: ENDOCRINE system; Subject Term: NITRIC-oxide synthases; Author-Supplied Keyword: Aroclor 1254; Author-Supplied Keyword: dl-α-Tocopherol (Vitamin E); Author-Supplied Keyword: Microdialysis; Author-Supplied Keyword: Neuroprotective; Author-Supplied Keyword: Nitric oxide synthase; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.tox.2005.08.017
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Gottlieb, Scott
T1 - Biomedical Research.
JO - Vital Speeches of the Day
JF - Vital Speeches of the Day
Y1 - 2005/12/15/
VL - 72
IS - 5
M3 - Speech
SP - 147
EP - 151
PB - Pro Rhetoric, LLC
SN - 0042742X
AB - The article presents a speech by Scott Gottlieb, deputy commissioner for medical and scientific affairs of the U.S. Food and Drug Administration, delivered to the Scientific Regulatory Meeting of the Pharmaceutical Research and Manufacturers of America Foundation in Washington, D.C. on November 29, 2005. He discusses research and development of drugs for treating and curing diseases, the decline in drug research productivity and the cost of developing drugs.
KW - PHARMACEUTICAL research
KW - DRUG development
KW - PHARMACEUTICAL industry
KW - UNITED States. Food & Drug Administration
KW - GOTTLIEB, Scott
N1 - Accession Number: 19893010; Gottlieb, Scott 1; Affiliation: 1: Deputy Commissioner, Medical and Scientific Affairs, Food and Drug Administration; Source Info: 12/15/2005, Vol. 72 Issue 5, p147; Subject Term: PHARMACEUTICAL research; Subject Term: DRUG development; Subject Term: PHARMACEUTICAL industry; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: GOTTLIEB, Scott; Number of Pages: 5p; Document Type: Speech; Full Text Word Count: 2997
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lagüe, Patrick
AU - Roux, Benoît
AU - Pastor, Richard W.
T1 - Molecular Dynamics Simulations of the Influenza Hemagglutinin Fusion Peptide in Micelles and Bilayers: Conformational Analysis of Peptide and Lipids
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
Y1 - 2005/12/16/
VL - 354
IS - 5
M3 - Article
SP - 1129
EP - 1141
SN - 00222836
AB - Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in two differently sized dodecylphosphocholine micelles and a palmitoyl oleoyl phosphatidylcholine bilayer were generated to analyze the influence of the environment. Four independent trajectories (5ns each for the bilayer, and 2ns each for the micelles) were generated for each system. The peptide lies at the surface of the micelles, while its N-terminal region inserts deeply in the bilayer. This leads to a substantial increase of the solvation and rigidity of the peptide in micelles as compared to the bilayer. The average structures, nevertheless, are similar in all three systems and agree reasonably with micelle-based NMR structures. When in the bilayer, the peptide increases the chain gauche population and area of adjacent lipids in the same binding leaflet, while it has the opposite effect for the nearby lipids of the other leaflet. These changes, which occur spontaneously to fill voids and defects, cause a decrease in the thickness of the membrane in the neighborhood of the peptide. They would be expected to promote positive curvature, as consistent with the formation of the convex bulge, or “nipple”, in the initial stage of membrane fusion. An extension of the classical surfactant theory of Israelachvili based on shapes is proposed to introduce the concept of a “dynamically induced shape” of the membrane lipids by the peptide. [Copyright &y& Elsevier]
AB - Copyright of Journal of Molecular Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMOLECULES
KW - COLLOIDS
KW - HEMAGGLUTININ
KW - AGGLUTINATION
KW - dodecylphosphocholine ( DPC )
KW - electron paramagnetic resonance ( EPR )
KW - fusion peptide
KW - hemagglutinin
KW - hemagglutinin ( HA )
KW - molecular dynamics
KW - molecular dynamics ( MD )
KW - palmitoyl oleoyl phosphatidylcholine ( POPC )
KW - palmitoyl oleoyl phosphatidylglycerol ( POPG )
KW - peptide–micelle interaction
KW - solvent accessible surface area ( SASA )
KW - viral fusion
N1 - Accession Number: 19153004; Lagüe, Patrick 1; Email Address: patrick.lague@rsvs.ulaval.ca Roux, Benoît 2 Pastor, Richard W. 1; Affiliation: 1: Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852-1448, USA 2: Department of Biochemistry (Box 63), Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA; Source Info: Dec2005, Vol. 354 Issue 5, p1129; Subject Term: BIOMOLECULES; Subject Term: COLLOIDS; Subject Term: HEMAGGLUTININ; Subject Term: AGGLUTINATION; Author-Supplied Keyword: dodecylphosphocholine ( DPC ); Author-Supplied Keyword: electron paramagnetic resonance ( EPR ); Author-Supplied Keyword: fusion peptide; Author-Supplied Keyword: hemagglutinin; Author-Supplied Keyword: hemagglutinin ( HA ); Author-Supplied Keyword: molecular dynamics; Author-Supplied Keyword: molecular dynamics ( MD ); Author-Supplied Keyword: palmitoyl oleoyl phosphatidylcholine ( POPC ); Author-Supplied Keyword: palmitoyl oleoyl phosphatidylglycerol ( POPG ); Author-Supplied Keyword: peptide–micelle interaction; Author-Supplied Keyword: solvent accessible surface area ( SASA ); Author-Supplied Keyword: viral fusion; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.jmb.2005.10.038
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19153004&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Green, Brett James
AU - Schmechel, Detlef
AU - Sercombe, Jason Kingsley
AU - Tovey, Euan Roger
T1 - Enumeration and detection of aerosolized Aspergillus fumigatus and Penicillium chrysogenum conidia and hyphae using a novel double immunostaining technique
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2005/12/20/
VL - 307
IS - 1/2
M3 - Article
SP - 127
EP - 134
SN - 00221759
AB - Abstract: The identification of collected airborne unicellular fungal conidia and hyphae using nonviable techniques is subjective and an imprecise process. Similarly, to determine whether an individual is allergic to a particular genus requires a separate immunodiagnostic analysis. This study demonstrates the development of a novel double immunostaining halogen assay, which enables (1) the simultaneous identification of collected airborne fungal conidia and hyphae of Aspergillus fumigatus and Penicillium chrysogenum using monoclonal antibodies and (2) the demonstration of patient-specific allergy to the same particles using human serum IgE. The results demonstrate that when conidia were ungerminated the binding of antibodies was homogeneous and localized in close proximity around the entire conidia for both species. However, when conidia were germinated, the proportion expressing antigen increased (P <0.0001) for both species and the sites of binding of the two antibodies changed with double immunostaining restricted to the hyphal tips for A. fumigatus, in addition to the sites of germination for P. chrysogenum. The described immunoassay has the potential to identify fungal particles in personal environmental air samples, provided species-specific monoclonal antibodies are available, while simultaneously demonstrating allergic sensitization to the same particles by co-staining the samples with the patient''s own serum. Such an immunoassay can use those fungi that the patient is actually exposed to and potentially avoids many problems associated with extract variability based on the performance of current diagnostic techniques for fungal allergy. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ASPERGILLUS
KW - ANTIGENS
KW - IMMUNOASSAY
KW - Allergen
KW - bovine serum albumin ( BSA )
KW - Conidia
KW - Fungi
KW - Germination
KW - halogen immunoassay ( HIA )
KW - horseradish peroxidase ( HRP )
KW - Immunoassay
KW - immunoglobulin E ( IgE )
KW - mixed cellulose ester ( MCE )
KW - Mold
KW - monoclonal antibody ( mAb )
KW - phosphate-buffered saline ( PBS )
KW - skin prick test ( SPT )
N1 - Accession Number: 19308087; Green, Brett James 1,2; Email Address: Brett.Green@cdc.hhs.gov Schmechel, Detlef 2 Sercombe, Jason Kingsley 3 Tovey, Euan Roger 1,3; Affiliation: 1: Department of Medicine, The University of Sydney, NSW, Australia 2: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M.S 4020, Morgantown, WV 26505-2888, United States 3: Woolcock Institute of Medical Research, Sydney, NSW, Australia; Source Info: Dec2005, Vol. 307 Issue 1/2, p127; Subject Term: IMMUNOGLOBULINS; Subject Term: ASPERGILLUS; Subject Term: ANTIGENS; Subject Term: IMMUNOASSAY; Author-Supplied Keyword: Allergen; Author-Supplied Keyword: bovine serum albumin ( BSA ); Author-Supplied Keyword: Conidia; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Germination; Author-Supplied Keyword: halogen immunoassay ( HIA ); Author-Supplied Keyword: horseradish peroxidase ( HRP ); Author-Supplied Keyword: Immunoassay; Author-Supplied Keyword: immunoglobulin E ( IgE ); Author-Supplied Keyword: mixed cellulose ester ( MCE ); Author-Supplied Keyword: Mold; Author-Supplied Keyword: monoclonal antibody ( mAb ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: skin prick test ( SPT ); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jim.2005.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moynahan, Megan
AU - Faris, Owen P.
AU - Lewis, Brian M.
T1 - Cardiac Resynchronization Devices: The Food and Drug Administration’s Regulatory Considerations
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2005/12/20/
VL - 46
IS - 12
M3 - Article
SP - 2325
EP - 2328
SN - 07351097
AB - Cardiac resynchronization therapy (CRT) devices have been studied clinically since 1998, and have been on the U.S. market since the Food and Drug Administration (FDA) approval of the first product in 2001. Since that time, the FDA has approved many different models from three different manufacturers, representing the first and second generations of these products. All of these products have undergone the FDA pre-market approval process, which examines the safety and effectiveness of the devices for their intended use. Over the last several years, the FDA has adapted recommendations for CRT clinical trials based on an evolving understanding of what these devices can achieve. This paper will outline the dynamic nature of the FDA’s approval process for CRT devices and briefly review the clinical trial designs for the first generation devices. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THERAPEUTICS
KW - HEART failure
KW - UNITED States
KW - cardiac resynchronization therapy ( CRT )
KW - ejection fraction ( EF )
KW - Food and Drug Administration ( FDA )
KW - implantable cardioverter-defibrillator ( ICD )
KW - left ventricular ( LV )
KW - New York Heart Association ( NYHA )
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 19200213; Moynahan, Megan; Email Address: megan.moynahan@fda.hhs.gov Faris, Owen P. 1 Lewis, Brian M. 1; Affiliation: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland; Source Info: Dec2005, Vol. 46 Issue 12, p2325; Subject Term: THERAPEUTICS; Subject Term: HEART failure; Subject Term: UNITED States; Author-Supplied Keyword: cardiac resynchronization therapy ( CRT ); Author-Supplied Keyword: ejection fraction ( EF ); Author-Supplied Keyword: Food and Drug Administration ( FDA ); Author-Supplied Keyword: implantable cardioverter-defibrillator ( ICD ); Author-Supplied Keyword: left ventricular ( LV ); Author-Supplied Keyword: New York Heart Association ( NYHA ); Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jacc.2005.04.068
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19200213&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106020158
T1 - Cardiac resynchronization devices: the Food and Drug Administration's regulatory considerations.
AU - Moynahan M
AU - Faris OP
AU - Lewis BM
Y1 - 2005/12/20/
N1 - Accession Number: 106020158. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8301365.
KW - Cardiac Output, Decreased -- Therapy
KW - Device Approval
KW - Pacemaker, Artificial -- Adverse Effects
KW - Pacemaker, Artificial -- Standards
KW - Cardiac Resynchronization Therapy
KW - Technology -- Trends
KW - Clinical Trials
KW - Product Evaluation
KW - Study Design
SP - 2325
EP - 2328
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
JA - J AM COLL CARDIOL
VL - 46
IS - 12
CY - New York, New York
PB - Elsevier Science
SN - 0735-1097
AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland 20850, USA. megan.moynahan@fda.hhs.gov
U2 - PMID: 16360066.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106020158&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chanvorachote, Pithi
AU - Nimmannit, Ubonthip
AU - Liying Wang
AU - Stehlik, Christian
AU - Bin Lu
AU - Azad, Neelam
AU - Rojanasakul, Yon
T1 - Nitric Oxide Negatively Regulates Fas CD95-induced Apoptosis through Inhibition of Ubiquitin-Proteasome-mediated Degradation of FLICE Inhibitory Protein.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2005/12/23/
VL - 280
IS - 51
M3 - Article
SP - 42044
EP - 42050
SN - 00219258
AB - Stimulation of cell surface Fas (CD95) results in recruitment of cytoplasmic proteins and activation of caspase-8, which in turn activates downstream effector caspases leading to programmed cell death. Nitric oxide (NO) plays a key role in the regulation of apoptosis, but its role in Fas-induced cell death and the underlying mechanism are largely unknown. Here we show that stimulation of the Fas receptor by its ligand (FasL) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein (FLIP) expression without significant effect on Fas and Fas-associated death domain (FADD) adapter protein levels. FLIP down-regulation as well as caspase-8 activation and apoptosis induced by FasL were all inhibited by the NO-liberating agent sodium nitroprusside and dipropylenetriamine NONOate, whereas the NO synthase inhibitor aminoguanidine and NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (PTIO) had opposite effects, indicating an anti-apoptotic role of NO in the Fas signaling process. FasL-induced down-regulation of FLIP is mediated by a ubiquitin-proteasome pathway that is negatively regulated by NO. S-nitrosylation of FLIP is an important mechanism rendering FLIP resistant to ubiquitination and proteasomal degradation by FasL. Deletion analysis shows that the caspase-like domain of FLIP is a key target for S-nitrosylation by NO, and mutations of its cysteine 254 and cysteine 259 residues completely inhibit S-nitrosylation, leading to increased ubiquitination and proteasomal degradation of FLIP. These findings indicate a novel pathway for NO regulation of FLIP that provides a key mechanism for apoptosis regulation and a potential new target for intervention in death receptor-associated diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL membranes
KW - CELL receptors
KW - MEMBRANE proteins
KW - APOPTOSIS
KW - CELL death
KW - NITRIC oxide
KW - NITROGEN compounds
KW - BIOCHEMISTRY
N1 - Accession Number: 19432521; Chanvorachote, Pithi 1,2 Nimmannit, Ubonthip 2; Email Address: ubonthip.n@chula.ac.th Liying Wang 3 Stehlik, Christian 4 Bin Lu 1 Azad, Neelam 1 Rojanasakul, Yon 1; Email Address: yrojanasakul@hsc.wvu.edu; Affiliation: 1: Department of Pharmaceutical Sciences 2: Pharmaceutical Technology (International) Program, Chulalongkorn University, Bangkok 10330, Thailand 3: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 4: Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506; Source Info: 12/23/2005, Vol. 280 Issue 51, p42044; Subject Term: CELL membranes; Subject Term: CELL receptors; Subject Term: MEMBRANE proteins; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: NITRIC oxide; Subject Term: NITROGEN compounds; Subject Term: BIOCHEMISTRY; Number of Pages: 7p; Illustrations: 8 Graphs; Document Type: Article
L3 - 0.1074/jbcM510080200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19432521&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weston, Ainsley
AU - Snyder, James
AU - McCanlies, Erin C.
AU - Schuler, Christine R.
AU - Andrew, Michael E.
AU - Kreiss, Kathleen
AU - Demchuk, Eugene
T1 - Immunogenetic factors in beryllium sensitization and chronic beryllium disease
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2005/12/30/
VL - 592
IS - 1/2
M3 - Article
SP - 68
EP - 78
SN - 00275107
AB - Abstract: Exposure to beryllium in the workplace can cause beryllium sensitization and chronic beryllium disease. Sensitization to beryllium can be detected in the laboratory using the beryllium lymphocyte proliferation test. It was shown that anti-HLA antibodies could block the beryllium-specific response in the beryllium lymphocyte proliferation test, thereby implicating HLA genes in chronic beryllium disease. A supratypic genetic marker, HLA-DPB1*E69, was found to be strongly associated with immunologic sensitization to beryllium and chronic beryllium disease in beryllium workers. However, there are 40 HLA-DPB1 gene variants that have E69 but that also have other DNA sequence variations. The purpose of the study was to evaluate the evidence for potential differential susceptibility that may be associated with the physical characteristics of HLA protein molecules for which different HLA-DPB1*E69 variants code; that is, do some HLA-DPB1*E69 variants convey higher risk of beryllium sensitization and chronic beryllium disease than others. To do this, two approaches were pursued: first, detailed analysis of the findings from the published literature was performed, and second, computational chemistry was used to seek clues concerning the physical properties of the HLA protein molecules for which these alleles code. Among the 40 HLA-DPB1 gene variants that code for E69, molecular epidemiological studies have suggested a risk hierarchy, where some variants appear to convey low to moderate risk of chronic beryllium disease (e.g., HLA-DPB1*0201, ∼3-fold increased risk), some convey an intermediate risk (e.g., HLA-DPB1*1901, ∼5-fold) and others convey high risk (e.g., HLA-DPB1*1701, >10-fold). Molecular modeling has been used to further investigate a potential mechanistic basis for these observations. We found a strong correlation between the hierarchical order of risk of chronic beryllium disease associated with specific alleles and the predicted surface electrostatic potential and charge of the corresponding isotypes. Therefore, when alleles were grouped by the relative negative charge on the molecules for which they code, the data suggest that those alleles associated with the most negatively charged proteins carry the greatest risk of beryllium sensitization and disease. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - BERYLLIUM
KW - HLA histocompatibility antigens
KW - POPULATION genetics
KW - EPIDEMIOLOGY
KW - allele-specific DNA sequencing ( ASDS )
KW - arginine ( R )
KW - aspartic acid ( D )
KW - Beryllium disease
KW - beryllium lymphocyte proliferation test ( BeLPT )
KW - Biomarkers
KW - chronic beryllium disease ( CBD )
KW - Genetic polymorphisms
KW - glutamic acid ( E )
KW - human leukocyte antigen ( HLA )
KW - lysine ( K )
KW - Molecular epidemiology
KW - National Institute for Occupational Safety and Health ( NIOSH )
KW - Occupational disease
KW - odds ratio ( OR )
KW - oligonucleotide hybridization ( OH )
KW - polymerase chain reaction ( PCR )
KW - restriction fragment length polymorphism ( RFLP )
KW - sequence specific primer PCR ( SSP )
N1 - Accession Number: 19129846; Weston, Ainsley 1; Email Address: agw8@cdc.gov Snyder, James 2 McCanlies, Erin C. 3 Schuler, Christine R. 4 Andrew, Michael E. 3 Kreiss, Kathleen 4 Demchuk, Eugene 1; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-3014, Morgantown, WV 26505-2888, USA 2: Analytical Services Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-3030, Morgantown, WV 26505-2888, USA 3: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-4020, Morgantown, WV 26505-2888, USA 4: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop H-2800, Morgantown, WV 26505-2888, USA; Source Info: Dec2005, Vol. 592 Issue 1/2, p68; Subject Term: GENETIC polymorphisms; Subject Term: BERYLLIUM; Subject Term: HLA histocompatibility antigens; Subject Term: POPULATION genetics; Subject Term: EPIDEMIOLOGY; Author-Supplied Keyword: allele-specific DNA sequencing ( ASDS ); Author-Supplied Keyword: arginine ( R ); Author-Supplied Keyword: aspartic acid ( D ); Author-Supplied Keyword: Beryllium disease; Author-Supplied Keyword: beryllium lymphocyte proliferation test ( BeLPT ); Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: chronic beryllium disease ( CBD ); Author-Supplied Keyword: Genetic polymorphisms; Author-Supplied Keyword: glutamic acid ( E ); Author-Supplied Keyword: human leukocyte antigen ( HLA ); Author-Supplied Keyword: lysine ( K ); Author-Supplied Keyword: Molecular epidemiology; Author-Supplied Keyword: National Institute for Occupational Safety and Health ( NIOSH ); Author-Supplied Keyword: Occupational disease; Author-Supplied Keyword: odds ratio ( OR ); Author-Supplied Keyword: oligonucleotide hybridization ( OH ); Author-Supplied Keyword: polymerase chain reaction ( PCR ); Author-Supplied Keyword: restriction fragment length polymorphism ( RFLP ); Author-Supplied Keyword: sequence specific primer PCR ( SSP ); NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2005.06.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19129846&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - Gen
ID - 9999-15321-000
AN - 9999-15321-000
AU - Cavazos-Rehg, Patricia A.
AU - Zayas, Luis H.
AU - Walker, Mark S.
AU - Fisher, Edwin B.
T1 - Abbreviated Hispanic Stress Inventory--Immigrant Version
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2006///
AD - Cavazos-Rehg, Patricia A., Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, One Brookings Drive, Campus Box 1093, St. Louis, Missouri, United States
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-15321-000. Acronyms: Abbreviated HSI-I. Partial author list: First Author & Affiliation: Cavazos-Rehg, Patricia A.; Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, Missouri, United States. Release Date: 20121008. Correction Date: 20151109. Instrument Type: Inventory/Questionnaire. Test Format: Participants indicate whether the particular stressor has occurred within the preceding 3 months. If the participant responds affirmatively to an item, then he or she is instructed to rate the degree of stressfulness of that incident on a 5-point Likert-type scale that ranges from 1 = not at all stressful to 5 = extremely stressful.. Language: English. Constructs: Immigrant Stress; Classification: Culture, Racial, and Ethnic Identity (5700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300).
N2 - Administration Method: Paper
AB - Purpose: The Abbreviated HSI-I assesses psychosocial experiences on five dimensions: occupational/economic, parental, marital, immigration, and familial/cultural.
AB - Description: To develop the Abbreviated Hispanic Stress Inventory--Immigrant Version (Abbreviated HSI-I; Cavazos-Rehg et al, 2006), a core set of items from the original 73-item HSI-I (Cervantes et al., 1991) was selected based on the magnitude of identified loadings of items on each of the five factors identified in the original development report. The abbreviated version of the HSI-I consists of 25 items and 5 subscales—Occupational/Economic Stress, Parental Stress, Marital Stress, Immigration Stress, and Family/Culture Stress. Participants are instructed to review each item and indicate whether the particular stressor has occurred within the preceding 3 months. If the participant responds affirmatively to an item, then he or she is instructed to rate the degree of stressfulness of that incident on a 5-point Likert-type scale that ranges from 1 = not at all stressful to 5 = extremely stressful. The abbreviated inventory was administered to a nonclinical sample of 143 adult Hispanic immigrants residing in a large midwestern city. Exploratory factor analysis supports a two-factor structure that combines factors identified in previous research. Internal consistencies are acceptable across all subscales, ranging from .68 to .83. Convergent validity of the abbreviated HSI-I revised is supported with moderately positive relations through self-report measures of depression, anxiety, and anger mood levels. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Abbreviated Hispanic Stress Inventory—Immigrant Version
KW - Test Development
KW - Hispanic Stress
KW - Factor Analysis
KW - Emotional Distress
KW - Acculturative Stress
KW - Occupational/Economic Stress Subscale
KW - Parental Stress Subscale
KW - Marital Stress Subscale
KW - Immigration Stress Subscale
KW - Family/Culture Stress Subscale
U5 - Abbreviated Hispanic Stress Inventory--Immigrant Version (Abbreviated HSI-I) [Test Development]Evaluating an Abbreviated Version of the Hispanic Stress Inventory for Immigrants. (AN: 2006-20091-002 from PsycINFO) Cavazos-Rehg, Patricia A.; Zayas, Luis H.; Walker, Mark S.; Fisher, Edwin B.; Nov, 2006. Source: Hispanic Journal of Behavioral Sciences. 28(4), Sage Publications, US; Nov, 2006; Administration: Paper Age Group: Adulthood (18 yrs & older); Population: Human; Male; Female; Location: US; Sample: Adult Hispanic Immigrants Keywords: Abbreviated Hispanic Stress Inventory—Immigrant Version; Test Development; Hispanic Stress; Factor Analysis; Emotional Distress; Acculturative Stress; Occupational/Economic Stress Subscale; Parental Stress Subscale; Marital Stress Subscale; Immigration Stress Subscale; Family/Culture Stress Subscale; Subjects: Acculturation; Immigration; Inventories; Latinos/Latinas; Marital Conflict; Parent Child Relations; Psychological Stress; Sociocultural Factors; Test Construction;
DO - 10.1037/t15321-000
L3 - Full; Full text; 999915321_full_001.pdf
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UR - pcavazos@im.wustl.edu
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
ID - 106412349
T1 - Endocrine problems in critically ill children: an overview.
AU - Trimarchi T
Y1 - 2006/01//
N1 - Accession Number: 106412349. Language: English. Entry Date: 20060324. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9508191.
KW - Critically Ill Patients -- In Infancy and Childhood
KW - Endocrine Diseases -- In Infancy and Childhood
KW - Adrenal Cortex Hormones -- Physiology
KW - Adrenal Gland Diseases
KW - Child
KW - Child, Preschool
KW - Diabetes Insipidus
KW - Diabetic Ketoacidosis -- Diagnosis
KW - Diabetic Ketoacidosis -- Therapy
KW - Endocrine System -- Physiology
KW - Family -- Education
KW - Fluid-Electrolyte Imbalance -- Drug Therapy
KW - Fluid-Electrolyte Imbalance -- Etiology
KW - Hormones -- Classification
KW - Hydrocortisone -- Administration and Dosage
KW - Hypoglycemia -- Prevention and Control
KW - Hypothalamic Hormones -- Physiology
KW - Hypothyroidism -- Symptoms
KW - Inappropriate ADH Syndrome
KW - Infant
KW - Nervous System Physiology
KW - Pancreas -- Physiology
KW - Patient Education
KW - Pediatric Critical Care Nursing
KW - Pituitary Hormones -- Physiology
KW - Syndrome
SP - 66
EP - 78
JO - AACN Clinical Issues: Advanced Practice in Acute & Critical Care
JF - AACN Clinical Issues: Advanced Practice in Acute & Critical Care
JA - AACN CLIN ISSUES ADV PRACT ACUTE CRIT CARE
VL - 17
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The endocrine system maintains a delicate balance of physiologic processes including growth and sexual maturation, energy production and utilization, fluid and electrolyte balance, and circulatory function. Although endocrine regulation of growth and sexual maturation is a significant issue in general pediatrics, disorders of energy production and utilization, fluid and electrolyte balance, and circulatory function are the endocrine causes of critical illness in children. Care of the child with critical endocrine disease requires an understanding of endocrine pathophysiology, keen history taking and assessment skills, and knowledge of the pharmacology of synthetic hormone treatment. This article will provide an overview of common endocrine problems encountered in critically ill children with attention to endocrine problems that are unique to pediatrics and that may pose diagnostic and treatment dilemmas for healthcare providers without experience or education in pediatric critical care.
SN - 1079-0713
AD - Clinical Process Manager, Children's Hospital of Philadelphia, Center for Quality and Patient Safety, 9th Floor South Tower, 34th St. and Civic Center Blvd., Philadelphia, PA 19104; trimarchi@email.chop.edu
U2 - PMID: 16462411.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Correa-de-Araujo, Rosaly
T1 - An operational definition of frailty predicted death, hip fracture, and hospitalization in older women: COMMENTARY.
JO - ACP Journal Club
JF - ACP Journal Club
Y1 - 2006/01//Jan/Feb2006
VL - 144
IS - 1
M3 - Article
SP - 23
EP - 23
SN - 10568751
AB - This article comments on a study conducted to predict death, hip fracture, and hospitalization in older women. Current operational definitions propose indicators to measure frailty, using clinical judgment on additional items and including standard geriatric assessment components. In the study researchers enrolled the largest sample examining frailty to date, included many health and demographic characteristics, and had lengthy follow-up on relevant outcomes. The ideal frailty measure identifies women not already overtly disabled but at risk for serious outcomes. Thus, the study is close to the ideal, as only 6% of frail women reported activity of daily living disabilities.
KW - OLDER women -- Diseases
KW - WOMEN -- Health
KW - OLDER people -- Health
KW - FRAIL elderly
KW - PARKINSON'S disease
KW - MENTAL depression
KW - HOSPITAL care
N1 - Accession Number: 19516016; Correa-de-Araujo, Rosaly 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland, USA; Source Info: Jan/Feb2006, Vol. 144 Issue 1, p23; Subject Term: OLDER women -- Diseases; Subject Term: WOMEN -- Health; Subject Term: OLDER people -- Health; Subject Term: FRAIL elderly; Subject Term: PARKINSON'S disease; Subject Term: MENTAL depression; Subject Term: HOSPITAL care; Number of Pages: 1/3p; Document Type: Article; Full Text Word Count: 375
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106428864
T1 - An operational definition of frailty predicted death, hip fracture, and hospitalization in older women.
AU - Correa-de-Araujo R
Y1 - 2006/01//Jan/Feb2006
N1 - Accession Number: 106428864. Language: English. Entry Date: 20060421. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary; tables/charts. Original Study: Woods NF, LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Brunner RL, et al. Frailty: emergence and consequences in women aged 65 and older in the women's health initiative observational study. (J AM GERIATR SOC) Aug2005; 53 (8): 1321-1330. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: RAND 36-Item Health Survey. NLM UID: 9104824.
KW - Frail Elderly
KW - Health Status -- In Old Age
KW - Women's Health
KW - Aged
KW - Clinical Assessment Tools
KW - Confidence Intervals
KW - Female
KW - Hip Fractures
KW - Hospitalization
KW - Logistic Regression
KW - Male
KW - Mortality
KW - Odds Ratio
KW - Prospective Studies
KW - Risk Factors
KW - United States
SP - 23
EP - 23
JO - ACP Journal Club
JF - ACP Journal Club
JA - ACP J CLUB
VL - 144
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
SN - 1056-8751
AD - Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 16388572.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106428864&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Mitra, Anu
AU - Swasy, Jack
AU - Aikin, Kathryn
T1 - How Do Consumers Interpret Market Leadership Claims in Direct-to-Consumer Advertising of Prescription Drugs?
JO - Advances in Consumer Research
JF - Advances in Consumer Research
Y1 - 2006/01//
VL - 33
IS - 1
M3 - Abstract
SP - 381
EP - 387
PB - Association for Consumer Research
SN - 00989258
AB - Claims such as "most prescribed" are commonly made by top-selling prescription drug brands in their direct-to-consumer (DTC) advertising. Under the FDA's current policy, sponsors may present "market leadership claims" (MLCs) with only sales data to support the claim. This paper examines how MLCs might affect consumers' product judgments and whether such claims evoke unwarranted inferences and beliefs about the superiority of the leading brand. Results of two studies suggest that market leadership claims in DTC advertising signal greater trust of the brand among prescribing doctors and imply superior product effectiveness under conditions when supporting survey and clinical data to support such inferences have not been provided. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advances in Consumer Research is the property of Association for Consumer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIRECT-to-consumer prescription drug advertising
KW - CONSUMER behavior
KW - ADVERTISING
KW - MARKETING research
KW - CONSUMER research
KW - PHARMACEUTICAL industry
KW - DRUGS
N1 - Accession Number: 23585740; Mitra, Anu 1; Swasy, Jack 1; Aikin, Kathryn 2; Affiliations: 1: American University; 2: Food and Drug Administration; Issue Info: 2006, Vol. 33 Issue 1, p381; Thesaurus Term: DIRECT-to-consumer prescription drug advertising; Thesaurus Term: CONSUMER behavior; Thesaurus Term: ADVERTISING; Thesaurus Term: MARKETING research; Thesaurus Term: CONSUMER research; Thesaurus Term: PHARMACEUTICAL industry; Subject Term: DRUGS; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Abstract
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106391843
T1 - Hepatitis C, HIV and injecting drug use in the UK.
AU - Smith J
Y1 - 2006/01//2006 Jan
N1 - Accession Number: 106391843. Language: English. Entry Date: 20060203. Revision Date: 20150711. Publication Type: Journal Article; statistics. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Peer Reviewed; UK & Ireland. NLM UID: 101092169.
KW - Hepatitis C -- Epidemiology
KW - HIV Infections -- Epidemiology
KW - Intravenous Drug Users -- United Kingdom
KW - Harm Reduction
KW - Risk Factors
KW - United Kingdom
SP - 1
EP - 3
JO - AIDS & Hepatitis Digest
JF - AIDS & Hepatitis Digest
JA - AIDS HEPATITIS DIGEST
IS - 111
CY - Athens,
PB - CCM International
SN - 1473-012X
AD - Research Scientist, Infection and Communicable Disease Service, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK; josie.smith@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106395966
T1 - Nursing resources. CAHPS and nursing practice [corrected] [published erratum appears in AM J NURS 2006;106(5):15.
AU - Farquhar MB
Y1 - 2006/01//
N1 - Accession Number: 106395966. Language: English. Entry Date: 20060217. Revision Date: 20150819. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Consumer Health Information
KW - Databases, Health
KW - Patient Satisfaction
KW - Quality of Health Care
KW - United States Agency for Healthcare Research and Quality
SP - 81
EP - 81
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 106
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Agency for Healthcare Research and Quality, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106395966&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106395958
T1 - Nursing resources. Morbidity and mortality online forum: the AHRQ examines, updates cases involving error [corrected] [published erratum appears in AM J NURS 2006;106(5):15].
AU - Farquhar MB
AU - Najar B
Y1 - 2006/01//
N1 - Accession Number: 106395958. Language: English. Entry Date: 20060217. Revision Date: 20150711. Publication Type: Journal Article; brief item; website. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Information Resources
KW - Morbidity
KW - Mortality
KW - Patient Safety
KW - World Wide Web
KW - United States Agency for Healthcare Research and Quality
SP - 81
EP - 82
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 106
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Health Scientist Administrator, Agency for Healthcare Research and Quality, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106395958&site=ehost-live&scope=site
UR - Related websites: www.webmm.ahrq.gov
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106467310
T1 - The importance of evidence-based disaster planning.
AU - Auf der Heide E
Y1 - 2006/01//
N1 - Accession Number: 106467310. Language: English. Entry Date: 20060707. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Commentary: Burstein JL. The myths of disaster education. (ANN EMERG MED) Jan2006; 47 (1): 50-52. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8002646.
KW - Disaster Planning -- Methods
KW - Emergency Medical Services -- Administration
KW - Emergency Medical Service Communication Systems -- Administration
KW - Medical Practice, Evidence-Based
KW - Communication
KW - Transportation of Patients -- Administration
KW - Health Resource Allocation -- Administration
KW - Professional Competence
KW - Rescue Work -- Administration
KW - Triage -- Administration
KW - Disaster Planning -- Trends
SP - 34
EP - 49
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
JA - ANN EMERG MED
VL - 47
IS - 1
CY - New York, New York
PB - Elsevier Science
AB - Disaster planning is only as good as the assumptions on which it is based. However, some of these assumptions are derived from a conventional wisdom that is at variance with empirical field disaster research studies. Knowledge of disaster research findings might help planners avoid common disaster management pitfalls, thereby improving disaster response planning. To illustrate the point, this article examines several common assumptions about disasters, compares them with research findings, and discusses the implications for planning. These assumptions are that: 1. Dispatchers will hear of the disaster and send emergency response units to the scene. 2. Trained emergency personnel will carry out field search and rescue. 3. Trained emergency medical services personnel will carry out triage, provide first aid or stabilizing medical care, and--if necessary--decontaminate casualties before patient transport. 4. Casualties will be transported to hospitals by ambulance. 5. Casualties will be transported to hospitals appropriate for their needs and in such a manner that no hospitals receive a disproportionate number. 6. Authorities at the scene will ensure that area hospitals are promptly notified of the disaster and the numbers, types, and severities of casualties to be transported to them. 7. The most serious casualties will be the first to be transported to hospitals. The current status and limitations of disaster research are discussed, and potential interventions to response problems are offered that may be of help to planners and practitioners and that may serve as hypotheses for future research.
SN - 0196-0644
AD - Medical Officer, Mailstop F-32, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, 1600 Clifton Rd, NE, Atlanta, GA; eaa9@cdc.gov
U2 - PMID: 16387217.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106467310&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2015-50222-007
AN - 2015-50222-007
AU - LaMascus, Alice Mankin
AU - Bernard, Marie A.
AU - Barry, Patricia
AU - Salerno, Judity
AU - Weiss, Joan
ED - Miles, Toni P.
ED - Furino, Antonio
ED - Miles, Toni P., (Ed)
ED - Furino, Antonio, (Ed)
T1 - Bridging the workforce gap for our aging society: How to increase and improve knowledge and training (report of an expert panel).
T2 - Annual review of gerontology and geriatrics, 2005: Aging healthcare workforce issues.
T3 - Annual review of gerontology and geriatrics; Vol 25; ISSN: 0198-8794 (Print)
Y1 - 2006///
VL - 25
SP - 121
EP - 132
CY - New York, NY, US
PB - Springer Publishing Co
SN - 0198-8794
SN - 0-8261-1736-8
SN - 978-0-8261-1736-6
SN - 978-0-8261-1739-7
N1 - Accession Number: 2015-50222-007. Partial author list: First Author & Affiliation: LaMascus, Alice Mankin; University of Oklahoma, Oklahoma City, OK, US. Release Date: 20160201. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8261-1736-8, Hardcover; 978-0-8261-1736-6, Hardcover; 978-0-8261-1739-7, Digital (undefined format). Language: English. Major Descriptor: Aging; Personnel Supply; Personnel Training; Professional Development; Health Personnel. Classification: Professional Education & Training (3410). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 12.
AB - This chapter summarizes the April 2003 conference, bridging the workforce gap for our aging society. Geriatricians and other experts from government and the private sector and from clinical and research backgrounds came together to offer their best advice and predictions for the future. They then formulated recommendations to meet the specific challenges relative to research, education, and patient care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient care
KW - improve knowledge
KW - workforce gap
KW - aging society
KW - geriatricians education
KW - 2006
KW - Aging
KW - Personnel Supply
KW - Personnel Training
KW - Professional Development
KW - Health Personnel
KW - 2006
U1 - Sponsor: US Department of Veterans Affairs, US. Recipients: No recipient indicated
U1 - Sponsor: Merck Institute of Aging and Health. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-50222-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Harper, Claudia
AU - Prater, Donald A.
T1 - Drugs Approved In The United States For Use In Aquaculture.
JO - Aquaculture Magazine
JF - Aquaculture Magazine
Y1 - 2006/01//Jan/Feb2006
VL - 32
IS - 1
M3 - Article
SP - 46
EP - 51
SN - 01991388
AB - The article provides information on the drugs approved for use in aquaculture in the U.S. Medicated feeds and immersion therapy are the most common routes of administration in aquaculture. Antimicrobials or medicated feeds used in aquaculture are distributed as either Type A medicated articles, or Type B or Type C medicated feeds. The U.S. Food and Drug Administration categorized medicated feeds by the requirement for a withdrawal period. Aquaflor, supplied by Schering-Plough Animal Health, is a Type A medicated article for the control of mortality in catfish due to enteric septicemia of catfish associated with Edwardsiella ictaluri.
KW - VETERINARY drugs
KW - MEDICATED feeds
KW - DRUGS
KW - AQUACULTURE
KW - FEEDS
KW - ANTI-infective agents
KW - UNITED States
KW - SCHERING-Plough Animal Health Corp.
N1 - Accession Number: 20520066; Harper, Claudia 1 Prater, Donald A. 2; Affiliation: 1: Clinical Veterinarian, Massachusetts General Hospital, Center for Comparative Medic 2: Leader, Aquaculture Drugs Team, FDA, Center for Veterinary Medicine, Rockville, Maryland, USA; Source Info: Jan/Feb2006, Vol. 32 Issue 1, p46; Subject Term: VETERINARY drugs; Subject Term: MEDICATED feeds; Subject Term: DRUGS; Subject Term: AQUACULTURE; Subject Term: FEEDS; Subject Term: ANTI-infective agents; Subject Term: UNITED States; Company/Entity: SCHERING-Plough Animal Health Corp.; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20520066&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106271023
T1 - Increasing prevalences of overweight and obesity in Northern Plains American Indian children.
AU - Zephier E
AU - Himes JH
AU - Story M
AU - Zhou X
Y1 - 2006/01//
N1 - Accession Number: 106271023. Language: English. Entry Date: 20070420. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by a grant from the Indian Health Service, Rockville, MD and partially supported by grant T79-MC0007-12 from the Maternal and Child Health Bureau, Rockville, MD. NLM UID: 9422751.
KW - Native Americans -- In Infancy and Childhood
KW - Obesity -- Epidemiology
KW - Adolescence
KW - Analysis of Variance
KW - Body Mass Index
KW - Child
KW - Child, Preschool
KW - Demography
KW - Female
KW - Funding Source
KW - Male
KW - Midwestern United States
KW - Prevalence
KW - Surveys
KW - Human
SP - 34
EP - 39
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 160
IS - 1
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - Aberdeen Area Indian Health Service, Aberdeen, SD, USA.
U2 - PMID: 16389208.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106271023&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106443847
T1 - Recently approved pharmaceutical agent nelarabine (ARRANON)
AU - Cohen MH
AU - Johnson JR
AU - Justice R
AU - Pazdur R
Y1 - 2006/01//2006 Jan
N1 - Accession Number: 106443847. Language: English. Entry Date: 20060519. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA.
KW - Drug Approval
KW - Leukemia, Lymphocytic, Acute -- Drug Therapy
KW - Nucleosides -- Therapeutic Use
KW - Prodrugs
KW - Age Factors
KW - Antineoplastic Agents -- Adverse Effects
KW - Clinical Trials
KW - Drug Toxicity
KW - Nucleosides -- Administration and Dosage
KW - Nucleosides -- Adverse Effects
KW - Nucleosides -- Pharmacodynamics
KW - Nucleosides -- Pharmacokinetics
KW - Recurrence
KW - Treatment Outcomes
KW - United States
KW - United States Food and Drug Administration
SP - 28
EP - 59
JO - ASCO News & Forum
JF - ASCO News & Forum
JA - ASCO NEWS FORUM
VL - 1
IS - 1
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 1931-7646
AD - Division of Oncology Drug Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106443847&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2006-04187-017
AN - 2006-04187-017
AU - Riley, Joseph L. III
ED - Mostofsky, David I.
ED - Forgione, Albert G.
ED - Giddon, Donald B.
ED - Mostofsky, David I., (Ed)
ED - Forgione, Albert G., (Ed)
ED - Giddon, Donald B., (Ed)
T1 - Behavioral Issues in Geriatric Dentistry.
T2 - Behavioral dentistry.
Y1 - 2006///
SP - 213
EP - 227
CY - Malden
PB - Blackwell Publishing
SN - 0-8138-1213-5
SN - 978-0-8138-1213-7
N1 - Accession Number: 2006-04187-017. Partial author list: First Author & Affiliation: Riley, Joseph L. III; University of Florida College of Dentistry, Public Health Service and Research, Gainesville, FL, US. Release Date: 20060522. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8138-1213-5, Paperback; 978-0-8138-1213-7, Paperback. Language: English. Major Descriptor: Dental Treatment; Dentistry; Geriatrics; Health Behavior; Teeth (Anatomy). Classification: Promotion & Maintenance of Health & Wellness (3365); Gerontology (2860). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 15.
AB - During the past several decades, the percentage of older adults who have retained their natural teeth has increased steadily (Burt & Eklund, 1999). However, the surgeon general's report on oral health and other studies indicate the overall dental health status of older adults is less than optimal (Oral Health in America, 2000). With the elderly retaining more of their natural teeth, they are becoming an increasingly larger and important part of dentists' practices due to increased life expectancy, declining edentulous rates, and improvements in dental specialties such as endodontics and periodontics. Older patients may present with more complex dental conditions due to many years of 'wear and tear' as well as with numerous complex medical conditions. This growing population poses special challenges to the dental practitioner from technical, physiological, social, and behavioral standpoints. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - teeth
KW - oral health
KW - geriatric dentistry
KW - dental treatment
KW - 2006
KW - Dental Treatment
KW - Dentistry
KW - Geriatrics
KW - Health Behavior
KW - Teeth (Anatomy)
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04187-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chang, Isaac
T1 - Review of "RF/Microwave Interaction with Biological Tissues" by André Vander Vorst, Arye Rosen, and Youji Kotsuka.
JO - BioMedical Engineering OnLine
JF - BioMedical Engineering OnLine
Y1 - 2006/01//
VL - 5
M3 - Book Review
SP - 50
EP - 2
PB - BioMed Central
SN - 1475925X
AB - The article reviews the book "RF/Microwave Interaction with Biological Tissues," by Andrè Vander Vorst, Arye Rosen, and Youji Kotsuka.
KW - TISSUES
KW - NONFICTION
KW - VANDER Vorst, Andre
KW - ROSEN, Arye
KW - KOTSUKA, Youji
KW - RF/MICROWAVE Interaction With Biological Tissues (Book)
N1 - Accession Number: 28781792; Chang, Isaac 1; Email Address: Isaac.Chang@fda.hhs.gov; Affiliation: 1: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20852, USA; Source Info: 2006, Vol. 5, p50; Subject Term: TISSUES; Subject Term: NONFICTION; Reviews & Products: RF/MICROWAVE Interaction With Biological Tissues (Book); People: VANDER Vorst, Andre; People: ROSEN, Arye; People: KOTSUKA, Youji; Number of Pages: 2p; Document Type: Book Review
L3 - 10.1186/1475-925X-5-50
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28781792&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2006-04286-027
AN - 2006-04286-027
AU - Love, John M.
AU - Tarullo, Louisa Banks
AU - Raikes, Helen
AU - Chazan-Cohen, Rachel
ED - McCartney, Kathleen
ED - Phillips, Deborah
ED - McCartney, Kathleen, (Ed)
ED - Phillips, Deborah, (Ed)
T1 - Head Start: What Do We Know About Its Effectiveness? What Do We Need to Know?
T2 - Blackwell handbook of early childhood development.
T3 - Blackwell handbooks of developmental psychology
Y1 - 2006///
SP - 550
EP - 575
CY - Malden
PB - Blackwell Publishing
SN - 1-4051-2073-8
SN - 978-1-4051-2073-9
N1 - Accession Number: 2006-04286-027. Partial author list: First Author & Affiliation: Love, John M.; Mathematica Policy Research Inc., Princeton, NJ, US. Release Date: 20060717. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-4051-2073-8, Hardcover; 978-1-4051-2073-9, Hardcover. Language: English. Major Descriptor: Childhood Development; Educational Programs; Program Evaluation; Project Head Start. Minor Descriptor: Policy Making. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Methodology: Literature Review. References Available: Y. Page Count: 26.
AB - In this chapter we summarize previous reviews of Head Start research and then examine more recent (within the past fifteen years) outcome and impact studies that have not been systematically summarized. The recent research includes descriptive studies and randomized impact evaluations; it includes both studies that examine very large national data sets and small-scale studies of particular programs or in particular communities. The cumulative evidence provides lessons for the child development field about when and how program experiences affect children's development, as well as lessons for programs seeking to enhance their services. We exclude from our review evaluations of 'Head Start-like' interventions, which many previous reviewers have merged with research on Head Start interventions. Even though broader reviews are useful for understanding the full range of early childhood interventions, we focus on studies of Head Start in the belief that the conclusions will be most useful to Head Start policy makers if we concentrate on research that has looked at programs implemented as part of the Head Start funding stream. We assert that although the extant research on Head Start is insufficient for certain purposes, it is sufficiently clear for others. We discuss the policy implications of the areas of sufficiency and the research implications for those areas that remain inconclusive. This review is necessarily selective; it provides a window on Head Start findings, not an exhaustive catalog of studies or findings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Head Start
KW - child development
KW - program evaluation
KW - policy
KW - 2006
KW - Childhood Development
KW - Educational Programs
KW - Program Evaluation
KW - Project Head Start
KW - Policy Making
KW - 2006
DO - 10.1002/9780470757703.ch27
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04286-027&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - van Bergen, Jan EAM
AU - Spaargaren, Joke
AU - Götz, Hannelore M
AU - Veldhuijzen, Irene K
AU - Bindels, Patrick JE
AU - Coenen, Ton J
AU - Broer, Jan
AU - de Groot, Fetzen
AU - Hoebe, Christian JPA
AU - Richardus, Jan-Hendrik
AU - van Schaik, Daniel
AU - Verhooren, Marije
T1 - Population prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in the Netherlands. should asymptomatic persons be tested during Population-based chlamydia Screening also for gonorrhoea or only if chlamydial infection is found?
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
Y1 - 2006/01//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 5
PB - BioMed Central
SN - 14712334
AB - Background: Screening and active case finding for Chlamydia trachomatis (CT) is recommended to prevent reproductive morbidity. However insight in community prevalence of gonococcal infections and co-infections with Neisseria gonorrhoea (NG) is lacking. Methods: Nested study within a large population-based Chlamydia Screening Pilot among 21.000 persons 15-29 year. All CT-positive (166) and a random sample of 605 CT-negative specimens were as well tested for gonococcal infection. Results: Overall Chlamydia prevalence in the Pilot was 2.0% (95% CI: 1.7-2.3), highest in very urban settings (3.2%; 95% CI: 2.4-4.0) and dependent of several risk factors. Four gonococcal infections were found among 166 participants with CT infection (4/166 = 2.4%; 95% CI: 0.1%-4.7%). All four had several risk factors and reported symptoms. Among 605 CT-negative persons, no infection with NG could be confirmed. Conclusion: A low rate of co-infections and a very low community prevalence of gonococcal infections were found in this population based screening programme among young adults in the Netherlands. Population screening for asymptomatic gonococcal infections is not indicated in the Netherlands. Although co-infection with gonorrhoea among CT-positives is dependent on symptoms and well-known algorithms for elevated risks, we advise to test all CT-positives also for NG, whether symptomatic or asymptomatic. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Infectious Diseases is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLAMYDIA trachomatis
KW - NEISSERIA gonorrhoeae
KW - CHLAMYDIA infections
KW - BACTERIAL diseases
KW - NETHERLANDS
N1 - Accession Number: 28796305; van Bergen, Jan EAM 1,2; Email Address: jvanbergen@soaaids.nl Spaargaren, Joke 3; Email Address: jspgrn@xs4all.nl Götz, Hannelore M 4; Email Address: gotzh@ggd.rotterdam.nl Veldhuijzen, Irene K 4; Email Address: veldhuijzeni@ggd.rotterdam.nl Bindels, Patrick JE 2; Email Address: p.j.bindels@amc.uva.nl Coenen, Ton J 1; Email Address: tcoenen@soaaids.nl Broer, Jan 5; Email Address: j.broer@hvd.groningen.nl de Groot, Fetzen 5; Email Address: fetzen.degroot@hvd.groningen.nl Hoebe, Christian JPA 6; Email Address: hoebec@ggdozl.nl Richardus, Jan-Hendrik 4,7; Email Address: J.Richardsus@erasmusmc.nl van Schaik, Daniel 1; Email Address: Ovanschaik@soaaids.nl Verhooren, Marije 8; Email Address: m.verhooren@ggdhvb.nl; Affiliation: 1: STI AIDS Netherlands (Soa Aids Nederland), Amsterdam, The Netherlands 2: Department of General Practice, Academic Medical Centre-University of Amsterdam, The Netherlands 3: Municipal Public Health Laboratory GGD Amsterdam, The Netherlands 4: Municipal Public Health Service Rotterdam, The Netherlands 5: Municipal Public Health Service Groningen, The Netherlands 6: Municipal Public Health Service South Limburg, The Netherlands 7: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands 8: Municipal Public Health Service "Hart van Brabant", The Netherlands; Source Info: 2006, Vol. 6 Issue 1, p1; Subject Term: CHLAMYDIA trachomatis; Subject Term: NEISSERIA gonorrhoeae; Subject Term: CHLAMYDIA infections; Subject Term: BACTERIAL diseases; Subject Term: NETHERLANDS; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1186/1471-2334-6-42
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28796305&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tobias, Jonathan
AU - Chilukuri, Ram
AU - Komatsoulis, George A
AU - Mohanty, Sambit
AU - Sioutos, Nicholas
AU - Warzel, Denise B.
AU - Wright, Lawrence W.
AU - Crowley, Rebecca S.
T1 - The CAP cancer protocols - a case study of caCORE based data standards implementation to integrate with the Cancer Biomedical Informatics Grid.
JO - BMC Medical Informatics & Decision Making
JF - BMC Medical Informatics & Decision Making
Y1 - 2006/01//
VL - 6
IS - 1
M3 - Article
SP - 25
EP - 19
PB - BioMed Central
SN - 14726947
AB - Background: The Cancer Biomedical Informatics Grid (caBIG™) is a network of individuals and institutions, creating a world wide web of cancer research. An important aspect of this informatics effort is the development of consistent practices for data standards development, using a multi-tier approach that facilitates semantic interoperability of systems. The semantic tiers include (1) information models, (2) common data elements, and (3) controlled terminologies and ontologies. The College of American Pathologists (CAP) cancer protocols and checklists are an important reporting standard in pathology, for which no complete electronic data standard is currently available. Methods: In this manuscript, we provide a case study of Cancer Common Ontologic Representation Environment (caCORE) data standard implementation of the CAP cancer protocols and checklists model - an existing and complex paper based standard. We illustrate the basic principles, goals and methodology for developing caBIG™ models. Results: Using this example, we describe the process required to develop the model, the technologies and data standards on which the process and models are based, and the results of the modeling effort. We address difficulties we encountered and modifications to caCORE that will address these problems. In addition, we describe four ongoing development projects that will use the emerging CAP data standards to achieve integration of tissue banking and laboratory information systems. Conclusion: The CAP cancer checklists can be used as the basis for an electronic data standard in pathology using the caBIG™ semantic modeling methodology. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Medical Informatics & Decision Making is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL informatics
KW - CANCER research
KW - ONTOLOGIES (Information retrieval)
KW - DATA structures (Computer science)
KW - COMPUTERS in medicine
N1 - Accession Number: 29404571; Tobias, Jonathan 1; Email Address: jotobias@mednet.ucla.edu Chilukuri, Ram 2; Email Address: ram.chilukuri@semanticbits.com Komatsoulis, George A 3; Email Address: komatsog@mail.nih.gov Mohanty, Sambit 4; Email Address: mohantys2@upmc.edu Sioutos, Nicholas 5; Email Address: nsioutos@mail.nih.gov Warzel, Denise B. 3; Email Address: warzeld@mail.nih.gov Wright, Lawrence W. 6; Email Address: lwright@mail.nih.gov Crowley, Rebecca S. 4,7,8; Email Address: crowleyrs@upmc.edu; Affiliation: 1: Department of Pathology, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA 2: SemanticBits, LLC, Reston, VA, USA 3: National Cancer Institute Center for Bioinformatics, National Institutes of Health, United States Department of Health and Human Services, Rockville, MD, USA 4: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 5: Lockheed Martin Information Technology, Rockville, MD, USA 6: Office of Communications, National Cancer Institute, Rockville, MD, USA 7: University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA 8: Center for Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Source Info: 2006, Vol. 6 Issue 1, p25; Subject Term: MEDICAL informatics; Subject Term: CANCER research; Subject Term: ONTOLOGIES (Information retrieval); Subject Term: DATA structures (Computer science); Subject Term: COMPUTERS in medicine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 19p; Document Type: Article
L3 - 10.1186/1472-6947-6-25
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ndiritu, Moses
AU - Cowgill, Karen D
AU - Ismail, Amina
AU - Chiphatsi, Salome
AU - Kamau, Tatu
AU - Fegan, Gregory
AU - Feikin, Daniel R.
AU - Newton, Charles R. J. C.
AU - Scott, J. Anthony G.
T1 - Immunization coverage and risk factors for failure to immunize within the Expanded Programme on Immunization in Kenya after introduction of new Haemophilus influenzae type b and hepatitis b virus antigens.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2006/01//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 8
PB - BioMed Central
SN - 14712458
AB - Background: Kenya introduced a pentavalent vaccine including the DTP, Haemophilus influenzae type b and hepatitis b virus antigens in Nov 2001 and strengthened immunization services. We estimated immunization coverage before and after introduction, timeliness of vaccination and risk factors for failure to immunize in Kilifi district, Kenya. Methods: In Nov 2002 we performed WHO cluster-sample surveys of >200 children scheduled for vaccination before or after introduction of pentavalent vaccine. In Mar 2004 we conducted a simple random sample (SRS) survey of 204 children aged 9-23 months. Coverage was estimated by inverse Kaplan-Meier survival analysis of vaccine-card and mothers' recall data and corroborated by reviewing administrative records from national and provincial vaccine stores. The contribution to timely immunization of distance from clinic, seasonal rainfall, mother's age, and family size was estimated by a proportional hazards model. Results: Immunization coverage for three DTP and pentavalent doses was 100% before and 91% after pentavalent vaccine introduction, respectively. By SRS survey, coverage was 88% for three pentavalent doses. The median age at first, second and third vaccine dose was 8, 13 and 18 weeks. Vials dispatched to Kilifi District during 2001-2003 would provide three immunizations for 92% of the birth cohort. Immunization rate ratios were reduced with every kilometre of distance from home to vaccine clinic (HR 0.95, CI 0.91-1.00), rainy seasons (HR 0.73, 95% CI 0.61-0.89) and family size, increasing progressively up to 4 children (HR 0.55, 95% CI 0.41-0.73). Conclusion: Vaccine coverage was high before and after introduction of pentavalent vaccine, but most doses were given late. Coverage is limited by seasonal factors and family size. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - HAEMOPHILUS influenzae
KW - HEPATITIS B virus
KW - ANTIGENS
KW - KENYA
N1 - Accession Number: 29362277; Ndiritu, Moses 1; Email Address: mndiritu@kilifi.kemri-wellcome.org Cowgill, Karen D 2; Email Address: KAREN.COWGILL@lshtm.ac.uk Ismail, Amina 3; Email Address: aismail@yahoo.com Chiphatsi, Salome 4; Email Address: schiphatsi@yahoo.com Kamau, Tatu 3; Email Address: kepi@swiftkenya.com Fegan, Gregory 1,5; Email Address: gfegan@kilifi.kemri-wellcome.org Feikin, Daniel R. 6; Email Address: dfeikin@ke.cdc.gov Newton, Charles R. J. C. 1,7; Email Address: cnewton@kilifi.kemriwellcome.org Scott, J. Anthony G. 1,8; Email Address: ascott@ikilifi.mimcom.net; Affiliation: 1: Wellcome Trust/Kenya Medical Research Institute, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya. 2: Epidemic Intelligence Service, Epidemiology Program Office, Division of Applied Public Health Training, Centers for Disease Control and Prevention Atlanta, GA, USA. 3: Kenya Expanded Programme on Immunization (KEPI), Ministry of Health, Nairobi, Kenya. 4: Kilifi District Public Health Service, Ministry of Health, Kilifi District Hospital, Kenya. 5: Infectious Diseases Epidemiology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, University of London, UK. 6: Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. 7: Institute of Child Health, University of London, London, UK. 8: Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.; Source Info: 2006, Vol. 6 Issue 1, p1; Subject Term: IMMUNIZATION; Subject Term: HAEMOPHILUS influenzae; Subject Term: HEPATITIS B virus; Subject Term: ANTIGENS; Subject Term: KENYA; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1186/1471-2458-6-132
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Werber, Dirk
AU - Evans, Meirion R.
AU - Thomas, Daniel Rh.
T1 - Identifying outbreaks of sexually transmitted infection: who cares?
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2006/01//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 4
PB - BioMed Central
SN - 14712458
AB - Background: Current routine surveillance schemes for sexually transmitted infections (STIs) in the United Kingdom (UK) are not designed for outbreak identification. Recognising STI outbreaks, therefore, depends almost entirely on the alertness of health professionals. The objective of this study was to explore health professionals' knowledge of, and attitudes towards, identification and investigation of STI outbreaks in Wales. Methods: We conducted a cross-sectional survey in Wales in June 2005, and sent a questionnaire to consultants of genitourinary medicine (GUM, n = 11), a consultant microbiologist from each laboratory (n = 14), all consultants in communicable disease control (n = 5), and to epidemiologists of the National Public Health Service (n = 4). Results: 26 (76%) of 34 survey recipients responded. Of these, 17 (65%) ranked the investigation of STI outbreaks as important or very important, and 19 (73%) perceived participation in the investigation of an STI outbreak as part of their responsibility. Only six (25%) respondents had actively searched their computer system or patient records for a possible STI outbreak in the previous twelve months, and 15 (63%) had never looked for an outbreak. Of seven GUM physicians who said they had identified at least one STI outbreak, three had never informed public health authorities. Conclusion: Prompt identification and coordinated investigation of outbreaks, usually through a multidisciplinary outbreak control team, is central to the control of many infectious diseases. This does not appear to be the case for STIs, which we believe represents a lost opportunity to reduce transmission. Besides improved surveillance methods, a change in culture towards STI outbreaks is needed among health professionals in Wales. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUALLY transmitted diseases
KW - HEALTH surveys
KW - MEDICAL scientists
KW - GREAT Britain
KW - GREAT Britain. National Health Service
N1 - Accession Number: 29362402; Werber, Dirk 1; Email Address: werberd@rki.de Evans, Meirion R. 1; Email Address: Meirion.Evans@nphs.wales.nhs.uk Thomas, Daniel Rh. 1; Email Address: Daniel.Thomas@nphs.wales.nhs.uk; Affiliation: 1: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Cardiff, Wales, UK.; Source Info: 2006, Vol. 6 Issue 1, p1; Subject Term: SEXUALLY transmitted diseases; Subject Term: HEALTH surveys; Subject Term: MEDICAL scientists; Subject Term: GREAT Britain; Company/Entity: GREAT Britain. National Health Service; Number of Pages: 4p; Document Type: Article
L3 - 10.1186/1471-2458-6-264
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fone, David L.
AU - Dunstan, Frank
AU - Christie, Stephen
AU - Jones, Andrew
AU - West, Jonathan
AU - Webber, Margaret
AU - Lester, Nathan
AU - Watkins, John
T1 - Council tax valuation bands, socio-economic status and health outcome: a cross-sectional analysis from the Caerphilly Health and Social Needs Study.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2006/01//
VL - 6
IS - 1
M3 - Article
SP - 115
EP - 13
PB - BioMed Central
SN - 14712458
AB - Council tax valuation bands (CTVBs) are a categorisation of household property value in Great Britain. The aim of the study was to assess the CTVB as a measure of socio-economic status by comparing the strength of the associations between selected health and lifestyle outcomes and CTVBs with two measures of socio-economic status: the National Statistics Socio-Economic Classification (NS-SEC) and the 2001 UK census-based Townsend deprivation index. Methods: Cross-sectional analysis of data on 12,092 respondents (adjusted response 62.7%) to the Caerphilly Health and Social Needs Study, a postal questionnaire survey undertaken in Caerphilly county borough, southeast Wales, UK. The CTVB was assigned to each individual by matching the sampling frame to the local authority council tax register. Crude and age-gender adjusted odds ratios for each category of CTVB, NS-SEC and fifth of the ward distribution of Townsend scores were estimated for smoking, poor diet, obesity, and limiting long-term illness using logistic regression. Mean mental (MCS) and physical (PCS) component summary scores of the Short-Form SF-36 health status questionnaire were estimated in general linear models. Results: There were significant trends in odds ratios across the CTVB categories for all outcomes, most marked for smoking and mental and physical health status. The adjusted odds ratio for being a smoker in the lowest versus highest CTVB category was 3.80 (95% CI: 3.06, 4.71), compared to 3.00 (95% CI: 2.30, 3.90) for the NS-SEC 'never worked and long-term unemployed' versus 'higher managerial and professional' categories, and 1.61 (95% CI: 1.42, 1.83) for the most deprived versus the least deprived Townsend fifth. The difference in adjusted mean MCS scores was 5.9 points on the scale for CTVB, 9.2 for NS-SEC and 3.2 for the Townsend score. The values for the adjusted mean PCS scores were 6.3 points for CTVB, 11.3 for NS-SEC, and 2.5 for the Townsend score. Conclusion: CTVBs assigned to individuals were strongly associated with the health and lifestyle outcomes modelled in this study. CTVBs are readily available for all residential properties and deserve further consideration as a proxy for socio-economic status in epidemiological studies in Great Britain. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL status
KW - LOGISTIC regression analysis
KW - MENTAL health
KW - CIGARETTE smokers
KW - EPIDEMIOLOGY -- Study & teaching
KW - GREAT Britain
N1 - Accession Number: 29362261; Fone, David L. 1,2; Email Address: foned@cf.ac.uk Dunstan, Frank 1; Email Address: dunstanfd@cf.ac.uk Christie, Stephen 3; Email Address: stephen.christie012@msd.govt.nz Jones, Andrew 4; Email Address: andrew.jones@nphs.wales.nhs.uk West, Jonathan 2; Email Address: jonathan.west@nphs.wales.nhs.uk Webber, Margaret 2; Email Address: margaret.webber@nphs.wales.nhs.uk Lester, Nathan 5; Email Address: nathan.lester@nphs.wales.nhs.uk Watkins, John 1,2; Email Address: john.watkins@nphs.wales.nhs.uk; Affiliation: 1: Department of Epidemiology, Statistics and Public Health, Centre for Health Sciences Research, School of Medicine, Cardiff, UK. 2: National Public Health Service for Wales, Mamhilad, Wales, UK. 3: Centre for Social Research and Evaluation, Ministry of Social Development, Wellington, New Zealand. 4: National Public Health Service for Wales, Bangor, Wales, UK. 5: National Public Health Service for Wales, Cardiff, Wales, UK.; Source Info: 2006, Vol. 6 Issue 1, p115; Subject Term: SOCIAL status; Subject Term: LOGISTIC regression analysis; Subject Term: MENTAL health; Subject Term: CIGARETTE smokers; Subject Term: EPIDEMIOLOGY -- Study & teaching; Subject Term: GREAT Britain; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 13p; Document Type: Article
L3 - 10.1186/1471-2458-6-115
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Levine, Jonathan G.
AU - Tonning, Joseph M.
AU - Szarfman, Ana
T1 - Reply: The evaluation of data mining methods for the simultaneous and systematic detection of safety signals in large databases: lessons to be learned.
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
Y1 - 2006/01//
VL - 61
IS - 1
M3 - Letter
SP - 105
EP - 113
PB - Wiley-Blackwell
SN - 03065251
AB - A response by Jonathan G. Levine, Joseph M. Tonning and Ana Szarfman about the state of data mining is pharmacovigilance.
KW - LETTERS to the editor
KW - DATA mining
N1 - Accession Number: 19091296; Levine, Jonathan G. 1,2 Tonning, Joseph M. 1 Szarfman, Ana 1; Affiliation: 1: Office of Pharmacoepidemiology and Statistical Sciences, Immediate Office, Center for Drug Evaluation and Research 2: Office of Women's Health, US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jan2006, Vol. 61 Issue 1, p105; Subject Term: LETTERS to the editor; Subject Term: DATA mining; Number of Pages: 9p; Illustrations: 3 Graphs; Document Type: Letter
L3 - 10.1111/j.1365-2125.2005.02510.x
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2009-01038-013
AN - 2009-01038-013
AU - Flanzer, Sally M.
AU - Yuan, Ying-Ying T.
AU - English, Diana J.
ED - Feerick, Margaret M.
ED - Knutson, John F.
ED - Trickett, Penelope K.
ED - Flanzer, Sally M.
ED - Feerick, Margaret M., (Ed)
ED - Knutson, John F., (Ed)
ED - Trickett, Penelope K., (Ed)
ED - Flanzer, Sally M., (Ed)
T1 - The impact of information technology on defining and classifying child abuse and neglect.
T2 - Child abuse and neglect: Definitions, classifications, and a framework for research.
Y1 - 2006///
SP - 341
EP - 357
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-759-4
SN - 978-1-55766-759-5
N1 - Accession Number: 2009-01038-013. Partial author list: First Author & Affiliation: Flanzer, Sally M.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20090706. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55766-759-4, Paperback; 978-1-55766-759-5, Paperback. Language: English. Major Descriptor: Child Abuse; Child Neglect; Information Technology; Taxonomies; Terminology. Minor Descriptor: Data Collection; Observation Methods; Privacy; Privileged Communication. Classification: Criminal Behavior & Juvenile Delinquency (3236); Communication Systems (2700). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 17.
AB - The chapter then discusses some approaches to examining variation in observations; additional features of information systems that can be useful in developing more comprehensive understandings of classifications made by workers, data analysis approaches to further deconstructing or reconstructing data categories, and advances in data merging that create greatest analytic potential for the primary data as well as newly created datasets. The chapter concludes with a discussion of some issues of privacy and confidentiality that may arise. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - information technology
KW - definitions
KW - classification
KW - child abuse & neglect
KW - observations
KW - privacy
KW - confidentiality
KW - data
KW - 2006
KW - Child Abuse
KW - Child Neglect
KW - Information Technology
KW - Taxonomies
KW - Terminology
KW - Data Collection
KW - Observation Methods
KW - Privacy
KW - Privileged Communication
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01038-013&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2009-01038-014
AN - 2009-01038-014
AU - Simmel, Cassandra
AU - Flanzer, Sally M.
AU - Webb, Mary Bruce
ED - Feerick, Margaret M.
ED - Knutson, John F.
ED - Trickett, Penelope K.
ED - Flanzer, Sally M.
ED - Feerick, Margaret M., (Ed)
ED - Knutson, John F., (Ed)
ED - Trickett, Penelope K., (Ed)
ED - Flanzer, Sally M., (Ed)
T1 - A new look at ethical issues in child maltreatment research.
T2 - Child abuse and neglect: Definitions, classifications, and a framework for research.
Y1 - 2006///
SP - 359
EP - 384
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-759-4
SN - 978-1-55766-759-5
N1 - Accession Number: 2009-01038-014. Partial author list: First Author & Affiliation: Simmel, Cassandra; School of Social Work, Rutgers University, New Brunswick, NJ, US. Release Date: 20090706. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-55766-759-4, Paperback; 978-1-55766-759-5, Paperback. Language: English. Major Descriptor: Child Abuse; Experimental Ethics. Minor Descriptor: Experimental Subjects; Foster Care; Professional Standards. Classification: Criminal Behavior & Juvenile Delinquency (3236); Professional Ethics & Standards & Liability (3450). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - Definitions of maltreatment exist with utility in various settings—legal, state agency, policy, research, and treatment. This chapter looks at how ethical considerations utilize a specifically defined event as maltreatment and how this affects the research process and the research participant, which in turn may be affected by specific contexts. In addition to reviewing current legal standards around enrolling vulnerable research subjects, this chapter also explores emerging issues and how the ethical dilemmas have changed as child maltreatment research has become more sophisticated. To illustrate these changes, examples of contemporary child abuse and neglect research projects that have addressed the new ethical challenges in measurement development, data collection, data handling, and analysis are provided. Last, close attention is paid to the complexities faced by researchers who directly study children residing in foster care who, because of the circumstances engendering their entry into substitute care, constitute a particularly vulnerable research population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethical issues
KW - child maltreatment
KW - research
KW - legal standards
KW - foster care
KW - participants
KW - 2006
KW - Child Abuse
KW - Experimental Ethics
KW - Experimental Subjects
KW - Foster Care
KW - Professional Standards
KW - 2006
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Equils, O.
AU - Naiki, Y.
AU - Shapiro, A. M.
AU - Michelsen, K.
AU - Lu, D.
AU - Adams, J.
AU - Jordan, S.
T1 - 1,25-Dihydroxyvitamin D3 inhibits lipopolysaccharide-induced immune activation in human endothelial cells.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2006/01//
VL - 143
IS - 1
M3 - Article
SP - 58
EP - 64
PB - Wiley-Blackwell
SN - 00099104
AB - In addition to its well-known role in mineral and skeletal homeostasis, 1,25-dihydroxyvitamin D3[1,25-(OH)2, D3] regulates the differentiation, growth and function of a broad range of immune system cells, including monocytes, dendritic cells, T and B lymphocytes. Vascular endothelial cells play a major role in the innate immune activation during infections, sepsis and transplant rejection; however, currently there are no data on the effect of 1,25-(OH)2 D3 on microbial antigen-induced endothelial cell activation. Here we show that 1,25-(OH)2 D3 pretreatment of human microvessel endothelial cells (HMEC) inhibited the enteric Gram-negative bacterial lipopolysaccharide (LPS) activation of transcription factor NF-κB and interleukin (IL)-6, IL-8 and regulated upon activation normal T cell exposed and secreted (RANTES) release. The effect of 1,25-(OH)2 D3 was not due to increased cell death or inhibition of endothelial cell proliferation. 1,25-(OH)2 D3 pretreatment of HMEC did not block MyD88-independent LPS-induced interferon (IFN)-β promoter activation. 1,25-(OH)2 D3 pretreatment of HMEC did not modulate Toll-like receptor 4 (TLR4) or MD-2 expression. These data suggest that 1,25-(OH)2 D3 may play a role in LPS-induced immune activation of endothelial cells during Gram-negative bacterial infections, and a suggest a potential role for 1,25-(OH)2 D3 and its analogues as an adjuvant in the treatment of Gram-negative sepsis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - LYMPHOCYTES
KW - INFECTION
KW - SEPTICEMIA
KW - BACTERIAL diseases
KW - BIOLOGICAL control systems
KW - endothelial cells
KW - IL-6
KW - IL-8
KW - lipopolysaccharide
KW - MD-2
KW - NF-κB
KW - NF-κB
KW - RANTES
KW - TLR4
KW - Toll-like receptor
KW - vitamin D
N1 - Accession Number: 18980079; Equils, O. 1; Email Address: ozlem.equils@cshs.org Naiki, Y. 1 Shapiro, A. M. 2 Michelsen, K. 1 Lu, D. 1 Adams, J. 3 Jordan, S. 1; Affiliation: 1: Department of Pediatrics, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center Geffen School of Medicine at UCLA, Los Angeles, CA 2: Division of Pediatric Drug Development, Office of Counter-Terrorism and Pediatric Drug Development Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 3: Department of Internal Medicine, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center Geffen School of Medicine at UCLA, Los Angeles, CA; Source Info: Jan2006, Vol. 143 Issue 1, p58; Subject Term: CELLS; Subject Term: LYMPHOCYTES; Subject Term: INFECTION; Subject Term: SEPTICEMIA; Subject Term: BACTERIAL diseases; Subject Term: BIOLOGICAL control systems; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: IL-6; Author-Supplied Keyword: IL-8; Author-Supplied Keyword: lipopolysaccharide; Author-Supplied Keyword: MD-2; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: RANTES; Author-Supplied Keyword: TLR4; Author-Supplied Keyword: Toll-like receptor; Author-Supplied Keyword: vitamin D; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1365-2249.2005.02961.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zaidi, Mussaret B.
AU - McDermott, Patrick F.
AU - Fedorka-Cray, Paula
AU - Leon, Verónica
AU - Canche, Claudia
AU - Hubert, Susannah K.
AU - Abbott, Jason
AU - León, Magda
AU - Zhao, Shaohua
AU - Headrick, Marcia
AU - Tollefson, Linda
T1 - Nontyphoidal Salmonella from Human Clinical Cases, Asymptomatic Children, and Raw Retail Meats in Yucatan, Mexico.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/01//1/1/2006
VL - 42
IS - 1
M3 - Article
SP - 21
EP - 28
SN - 10584838
AB - Background. We report the results of a 3-year Salmonella surveillance study of persons with diarrhea; asymptomatic children; and retail pork, poultry, and beef in Yucatan, Mexico. Methods. Isolates were characterized according to serotype, antimicrobial susceptibility, and genetic relatedness with pulsed-field gel electrophoresis. Results. Salmonella Typhimurium was the most common serotype found in ill humans (21.8% of isolates), followed by Salmonella Agona (21% of isolates). Salmonella Enteritidis was a minor serotype (4.2% of isolates). Asymptomatic children carried S. Agona (12.1% of isolates), Salmonella Meleagridis (11.6% of isolates), Salmonella Anatum (8% of isolates) and S. Enteritidis (5.8% of isolates). A high percentage of retail meat samples contained Salmonella; it was most commonly found in pork (58.1% of samples), followed by beef (54% of samples) and poultry (39.7% of samples). Resistance to oral drugs used for the treatment of salmonellosis was observed for ampicillin (14.6% of isolates were resistant), chloramphenicol (14.0% of isolates), and trimethoprim-sulfamethoxazole (19.7% of isolates). Resistance to ceftriaxone emerged in 2002 and was limited to the serotype S. Typhimurium. Twenty-seven percent of the isolates were resistant to nalidixic acid, and none were resistant to ciprofloxacin. Multidrug resistance was most common among isolates of serotypes S. Typhimurium and S. Anatum. Pulsed-field gel electrophoresis showed that strains found in retail meats were genetically identical to strains found in both asymptomatic children and ill patients. Conclusions. Our study found a high prevalence of Salmonella in retail meats and persons with enteric infection; many of these isolates were resistant to clinically important antimicrobials. A random selection of isolates from people and retail meat showed genetic relatedness, which suggests that, in Yucatan, considerable transfer of Salmonella occurs through the food chain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food poisoning
KW - Anti-infective agents
KW - Salmonella typhimurium
KW - Meat industry
KW - Mexico
N1 - Accession Number: 19262024; Zaidi, Mussaret B. 1; Email Address: mbzaidi@yuc.quik.com; McDermott, Patrick F. 2; Fedorka-Cray, Paula 3; Leon, Verónica 1; Canche, Claudia 1; Hubert, Susannah K. 2; Abbott, Jason 2; León, Magda 1; Zhao, Shaohua 2; Headrick, Marcia 2; Tollefson, Linda 2; Affiliations: 1: Laboratorio de Investigación, Hospital General O'Horan, Mérida, Yucatan, Mexico.; 2: Center for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland.; 3: Antimicrobial Resistance Research Unit-United States Department of Agriculture-Russell Research Center, Athens, Georgia.; Issue Info: 1/1/2006, Vol. 42 Issue 1, p21; Thesaurus Term: Salmonella; Thesaurus Term: Food poisoning; Thesaurus Term: Anti-infective agents; Subject Term: Salmonella typhimurium; Subject Term: Meat industry; Subject: Mexico; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 311612 Meat Processed from Carcasses; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
TY - GEN
AU - Evans, G;
T1 - Update on vaccine liability in the United States: Presentation at the National Vaccine Program Office Workshop on strengthening the supply of routinely recommended vaccines in the United States, 12 February 2002
CT - Update on vaccine liability in the United States: Presentation at the National Vaccine Program Office Workshop on strengthening the supply of routinely recommended vaccines in the United States, 12 February 2002
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/01/01/
VL - 42
IS - MAR 1
SP - S130
EP - S125
SN - 10584838
AD - Hlth Resources & Serv Adm, Dept Hlth & Human Serv, 5600 Fishers Ln, Rm 11C-26, Rockville, MD 20857, USA gevans@hrsa.gov
N1 - Accession Number: 43-05768; Language: English; References: 24; Publication Type: Proceedings; Journal Coden: CINFDE; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and Ethics
N2 - Two decades ago, a liability crisis brought on by concerns about the safety of diphtheria and tetanus toxoids and pertussis vaccine led to supply shortages and calls for rationing of the vaccine. Vaccine prices skyrocketed, and research on new products was threatened. In response, Congress created the National Vaccine Injury Compensation Program, which is tort reform legislation designed to compensate individuals quickly, easily, and generously. Since 1988, the Vaccine Injury Compensation Program has stabilized the marketplace, as evidenced by high immunization rates, stable pricing, and an increasing number of vaccine candidates in development. Although current vaccine shortages do not appear to be related to issues of liability, a new wave of tort litigation alleging that some vaccines cause autism has led to speculation that history could repeat itself.
KW - Vaccines--policies and procedures;
KW - Manufacturers--vaccines;
KW - Interventions--vaccines;
KW - Legislation--vaccines;
KW - Supplies--vaccines;
KW - Liability--vaccines;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Hoflund, A.
AU - Farquhar, Marybeth
T1 - Networks and Regulation in Healthcare: A Case Study of the National Quality Forum.
JO - Conference Papers -- Law & Society
JF - Conference Papers -- Law & Society
Y1 - 2006///2006 Annual Meeting
M3 - Article
SP - 1
AB - Networks are an increasingly common aspect of administrative life in almost any public policy arena. In health care, networks have emerged in order to address issues of efficiency, effectiveness, safety, and quality of care. One organization, the National Quality Forum (NQF), was established to address these issues through a unique consensus process involving diverse stakeholders within the health care industry. Established in 1999, the NQF's mission is "to develop a comprehensive quality measurement and reporting strategy that addresses priorities for quality measurement consistent with national aims for quality improvement in health care." The NQF brings together organizations from the public and private sectors in a forum to discuss and debate quality and performance measurement issues. Its goal is to gain consensus among these stakeholders to improve the quality of health care. Network organizations like the NQF can be thought of as a form of democratic experimentalism. Dorf and Sabel (1998) coined the term to describe a new form of governance, one that is based on the pragmatic principles of information sharing, resource pooling, and learning through experience. The NQF thus represents a regulatory experiment in addressing health policy issues. This paper provides an overview of the National Quality Forum and the network that has formed around this organization. This paper also explores the regulatory implications of the NQF and how this new form of governance coexists with the more traditional forms of regulation in health care. ..PAT.-Unpublished Manuscript [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- Law & Society is the property of Law & Society Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH care networks
KW - ASSOCIATIONS, institutions, etc.
KW - HEALTH care industry
KW - MEDICAL policy
KW - SAFETY
KW - FEDERAL regulation
N1 - Accession Number: 34893878; Hoflund, A. 1; Email Address: ahoflund@vt.edu Farquhar, Marybeth 2; Email Address: mfarquha@ahrq.gov; Affiliation: 1: Virginia Polytechnic Institute & State University 2: Agency for Healthcare Research and Quality; Source Info: 2006 Annual Meeting, p1; Subject Term: HEALTH care networks; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: HEALTH care industry; Subject Term: MEDICAL policy; Subject Term: SAFETY; Subject Term: FEDERAL regulation; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; Number of Pages: 0p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Ruder, Avima M.
AU - Hein, Misty J.
AU - Nilsen, Nancy
AU - Waters, Martha A.
AU - Laber, Patricia
AU - Davis-King, Karen
AU - Prince, Mary M.
AU - Whelan, Elizabeth
T1 - Mortality among Workers Exposed to Polychlorinated Biphenyls (PCBs) in an Electrical Capacitor Manufacturing Plant in Indiana: An Update.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/01//
VL - 114
IS - 1
M3 - Article
SP - 18
PB - Superintendent of Documents
SN - 00916765
AB - An Indiana capacitor-manufacturing cohort (n = 3,569) was exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The original study of mortality through 1984 found excess melanoma and brain cancer; other studies of PCB-exposed individuals have found excess non-Hodgkin lymphoma and rectal, liver, biliary tract, and gallbladder cancer. Mortality was updated through 1998. Analyses have included standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) using rates for Indiana and the United States, standardized rate ratios (SRRs), and Poisson regression rate ratios (RRs). Estimated cumulative exposure calculations used a new job-exposure matrix. Mortality overall was reduced (547 deaths; SMR, 0.81; 95% CI, 0.7-0.9). Non-Hodgkin lymphoma mortality was elevated (9 deaths; SMR, 1.23; 95% CI, 0.6-2.3). Melanoma remained in excess (9 deaths; SMR, 2.43; 95% CI, 1.1-4.6), especially in the lowest tertile of estimated cumulative exposure (5 deaths; SMR, 3.72; 95% CI, 1.2-8.7). Seven of the 12 brain cancer deaths (SMR, 1.91; 95% CI, 1.0-3.3) occurred after the original study. Brain cancer mortality increased with exposure (in the highest tertile, 5 deaths; SMR, 2.71; 95% CI, 0.9-6.3); the SRR dose-response trend was significant (p = 0.016). Among those working ≥ 90 days, both melanoma (8 deaths; SMR, 2.66; 95% CI, 1.1-5.2) and brain cancer (11 deaths; SMR, 2.12; 95% CI, 1.1-3.8) were elevated, especially for women: melanoma, 3 deaths (SMR, 5.99; 95% CI, 1.2-17.5); brain cancer, 3 deaths (SMR, 2.87; 95% CI, 0.6-8.4). These findings of excess melanoma and brain cancer mortality confirm results of the original study. Melanoma mortality was not associated with estimated cumulative exposure. Brain cancer mortality did not demonstrate a clear dose-response relationship with estimated cumulative exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Polychlorinated biphenyls
KW - Public health
KW - Mortality
KW - Melanoma
KW - Brain cancer
KW - Lymphomas
KW - Indiana
KW - cancer
KW - cohort study
KW - exposure assessment
KW - occupational exposure
KW - polychlorinated biphenyls
N1 - Accession Number: 19315357; Ruder, Avima M. 1; Email Address: amr2@cdc.gov; Hein, Misty J. 1; Nilsen, Nancy 1; Waters, Martha A. 1; Laber, Patricia 1; Davis-King, Karen 1; Prince, Mary M. 1; Whelan, Elizabeth 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Jan2006, Vol. 114 Issue 1, p18; Thesaurus Term: Industrial hygiene; Thesaurus Term: Polychlorinated biphenyls; Thesaurus Term: Public health; Subject Term: Mortality; Subject Term: Melanoma; Subject Term: Brain cancer; Subject Term: Lymphomas; Subject: Indiana; Author-Supplied Keyword: cancer; Author-Supplied Keyword: cohort study; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: polychlorinated biphenyls; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1289/ehp.8253
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106131684
T1 - Mortality among workers exposed to polychlorinated biphenyls (PCBs) in an electrical capacitor manufacturing plant in Indiana: an update.
AU - Ruder AM
AU - Hein MJ
AU - Nilsen N
AU - Waters MA
AU - Laber P
AU - Davis-King K
AU - Prince MM
AU - Whelan E
Y1 - 2006/01//
N1 - Accession Number: 106131684. Language: English. Entry Date: 20070810. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Grant Information: National Institute for Occupational Safety and Health (NIOSH). NLM UID: 0330411.
KW - Occupational Diseases -- Mortality
KW - Occupational Exposure
KW - Polychlorinated Biphenyls
KW - Adult
KW - Cause of Death
KW - Confidence Intervals
KW - Data Analysis Software
KW - Electronics
KW - Female
KW - Funding Source
KW - Indiana
KW - Industry
KW - Male
KW - Poisson Distribution
KW - Prospective Studies
KW - Spearman's Rank Correlation Coefficient
KW - Two-Tailed Test
KW - Human
SP - 18
EP - 23
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 114
IS - 1
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - An Indiana capacitor-manufacturing cohort (n=3,569) was exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The original study of mortality through 1984 found excess melanoma and brain cancer; other studies of PCB-exposed individuals have found excess non-Hodgkin lymphoma and rectal, liver, biliary tract, and gallbladder cancer. Mortality was updated through 1998. Analyses have included standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) using rates for Indiana and the United States, standardized rate ratios (SRRs), and Poisson regression rate ratios (RRs). Estimated cumulative exposure calculations used a new job-exposure matrix. Mortality overall was reduced (547 deaths; SMR, 0.81; 95% CI, 0.7-0.9). Non-Hodgkin lymphoma mortality was elevated (9 deaths; SMR, 1.23; 95% CI, 0.6-2.3). Melanoma remained in excess (9 deaths; SMR, 2.43; 95% CI, 1.1-4.6), especially in the lowest tertile of estimated cumulative exposure (5 deaths; SMR, 3.72; 95% CI, 1.2-8.7). Seven of the 12 brain cancer deaths (SMR, 1.91; 95% CI, 1.0-3.3) occurred after the original study. Brain cancer mortality increased with exposure (in the highest tertile, 5 deaths; SMR, 2.71; 95% CI, 0.9-6.3); the SRR dose-response trend was significant (p=0.016). Among those working >or= 90 days, both melanoma (8 deaths; SMR, 2.66; 95% CI, 1.1-5.2) and brain cancer (11 deaths; SMR, 2.12; 95% CI, 1.1-3.8) were elevated, especially for women: melanoma, 3 deaths (SMR, 5.99; 95% CI, 1.2-17.5); brain cancer, 3 deaths (SMR, 2.87; 95% CI, 0.6-8.4). These findings of excess melanoma and brain cancer mortality confirm results of the original study. Melanoma mortality was not associated with estimated cumulative exposure. Brain cancer mortality did not demonstrate a clear dose-response relationship with estimated cumulative exposure.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. amr2@cdc.gov
U2 - PMID: 16393652.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Prince, Mary M.
AU - Hein, Misty J.
AU - Ruder, Avima M.
AU - Waters, Martha A.
AU - Laber, Patricia A.
AU - Whelan, Elizabeth A.
T1 - Update: cohort mortality study of workers highly exposed to polychlorinated biphenyls (PCBs) during the manufacture of electrical capacitors, 1940-1998.
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
Y1 - 2006/01//
VL - 5
M3 - Article
SP - 13
EP - 10
PB - BioMed Central
SN - 1476069X
AB - Background: The National Institute for Occupational Safety and Health previously reported mortality for a cohort of workers considered highly exposed to polychlorinated biphenyls (PCBs) between 1939 and 1977 at two electrical capacitor manufacturing plants. The current study updated vital status, examined liver and rectal cancer mortality previously reported in excess in this cohort and evaluated mortality from non-Hodgkin's lymphoma (NHL) and cancers of the stomach, intestine, breast, prostate, skin (melanoma) and brain reported to be in excess in other cohort and case-control studies of PCB-exposed persons. Methods: Mortality was updated through 1998 for 2572 workers. Age-, gender-, race- and calendar yearadjusted standardized mortality ratios (SMRs) and 95% confidence intervals (CI) were calculated using U.S., state and county referent rates. SMRs using U.S. referent rates are reported. Duration of employment was used as a surrogate for exposure. Results: Consistent with the previous follow-up, mortality from biliary passage, liver and gall bladder cancer was significantly elevated (11 deaths, SMR 2.11, CI 1.05 - 3.77), but mortality from rectal cancer was not (6 deaths, SMR 1.47, CI 0.54 - 3.21). Among women, mortality from intestinal cancer (24 deaths, SMR 1.89, CI 1.21 - 2.82) and from "other diseases of the nervous system and sense organs", which include Parkinson's disease and amyotrophic lateral sclerosis, (15 deaths, SMR 2.07, CI 1.16 - 3.42) were elevated. There were four ALS deaths, all women (SMR 4.35, CI 1.19-11.14). Mortality was elevated for myeloma (7 deaths, SMR 2.11, CI 0.84 - 4.34), particularly among workers employed 10 years or more (5 deaths, SMR 2.80, CI 0.91 - 6.54). No linear associations between mortality and duration of employment were observed for the cancers of interest. Conclusion: This update found that the earlier reported excess in this cohort for biliary, liver and gall bladder cancer persisted with longer follow-up. Excess mortality for intestinal cancer among women was elevated across categories of duration of employment; myeloma mortality was highest among those working 10 years or more. The small numbers of deaths from liver and intestinal cancers, myeloma and nervous system diseases coupled with the lack of an exposure-response relationship with duration of employment preclude drawing definitive conclusions regarding PCB exposure and these causes of death. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COHORT analysis
KW - OCCUPATIONAL diseases
KW - POLYCHLORINATED biphenyls
KW - CAPACITORS
KW - HODGKIN'S disease
KW - PARKINSON'S disease
N1 - Accession Number: 28742687; Prince, Mary M. 1; Email Address: mmprince12@earthlink.net Hein, Misty J. 1; Email Address: zcr9@cdc.gov Ruder, Avima M. 1; Email Address: amr2@cdc.gov Waters, Martha A. 1; Email Address: maw0@cdc.gov Laber, Patricia A. 1; Email Address: pal0@cdc.gov Whelan, Elizabeth A. 1; Email Address: eaw0@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluation and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA; Source Info: 2006, Vol. 5, p13; Subject Term: COHORT analysis; Subject Term: OCCUPATIONAL diseases; Subject Term: POLYCHLORINATED biphenyls; Subject Term: CAPACITORS; Subject Term: HODGKIN'S disease; Subject Term: PARKINSON'S disease; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 334416 Capacitor, Resistor, Coil, Transformer, and Other Inductor Manufacturing; NAICS/Industry Codes: 335999 All Other Miscellaneous Electrical Equipment and Component Manufacturing; NAICS/Industry Codes: 423690 Other Electronic Parts and Equipment Merchant Wholesalers; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1186/1476-069X-5-13
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun Young Lee
AU - Dae Youn Hwang
AU - Young Kyu Kim
AU - Jae Woong Lee
AU - Im Chul Shin
AU - Ki Wan Oh
AU - Myung Koo Lee
AU - Jong Seok Lim
AU - Do Young Yoon
AU - Se Jin Hwang
AU - Jin Tae Hong
T1 - PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2006/01//
VL - 20
IS - 1
M3 - Article
SP - 151
EP - 153
AB - The article discusses that PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. The increased vulnerability, intracellular calcium level, and colocalization of RyR and PS2 in the neuronal cells expressing mutant PS2 was analyzed. Caspase-3 activity in the neuronal cells expressing wild-type or mutant PS2 and the effect of RyR inhibitor dantrolene was discussed.
KW - NEUROTOXIC agents
KW - RYANODINE receptors
KW - DANTROLENE
KW - POISONS
KW - CALCIUM channels
KW - HYDANTOIN
KW - MUSCLE relaxants
N1 - Accession Number: 19657453; Sun Young Lee 1 Dae Youn Hwang 2 Young Kyu Kim 2 Jae Woong Lee 1 Im Chul Shin 1 Ki Wan Oh 1 Myung Koo Lee 1 Jong Seok Lim 3 Do Young Yoon 3 Se Jin Hwang 4 Jin Tae Hong 1; Email Address: jinthong@chungbuk.ac.kr; Affiliation: 1: College of Pharmacy, Chungbuk National University, Chungbuk, Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea 3: Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea 4: College of Medicine, Hanyang University, Seoul, Korea; Source Info: Jan2006, Vol. 20 Issue 1, p151; Subject Term: NEUROTOXIC agents; Subject Term: RYANODINE receptors; Subject Term: DANTROLENE; Subject Term: POISONS; Subject Term: CALCIUM channels; Subject Term: HYDANTOIN; Subject Term: MUSCLE relaxants; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1096/fj.05-4017fje
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2006-03272-001
AN - 2006-03272-001
AU - Kelloway, E. Kevin
AU - Barling, Julian
AU - Hurrell, Joseph Jr.
T1 - Editors' Introduction to Part I.
T2 - Handbook of workplace violence.
Y1 - 2006///
SP - 3
EP - 6
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-7619-3062-0
N1 - Accession Number: 2006-03272-001. Partial author list: First Author & Affiliation: Kelloway, E. Kevin; Saint Mary's University, Halifax, NS, Canada. Release Date: 20060724. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-7619-3062-0, Hardcover. Language: English. Major Descriptor: Aggressive Behavior; Violence; Working Conditions; Workplace Violence. Classification: Behavior Disorders & Antisocial Behavior (3230); Organizational Behavior (3660). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 4.
AB - Like work, this handbook is fundamentally about violence. Our intent was to bring together the leading researchers to summarize the current state of knowledge and to begin to chart the course for future research. The chapters in this first section provide an appropriate foundation for this endeavor. The study of aggression and violence is characterized by two fundamental theoretical orientations: the rational choice model and the frustration-aggression hypothesis. It is not clear that these are competing, as much as complementary, approaches that have something to tell us about the causes of workplace violence and aggression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - aggression
KW - workplace violence
KW - 2006
KW - Aggressive Behavior
KW - Violence
KW - Working Conditions
KW - Workplace Violence
KW - 2006
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106358076
T1 - The science link.
AU - Ward M
Y1 - 2006/01//
N1 - Accession Number: 106358076. Language: English. Entry Date: 20061110. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101220695.
KW - Community Health Services
KW - Coronary Disease -- Prevention and Control
KW - Health Promotion -- Methods
KW - Physical Activity
KW - Health Behavior
KW - Patient Assessment -- Methods
KW - Physicians, Family
KW - Referral and Consultation
KW - United Kingdom
SP - 18
EP - 19
JO - HealthEX Specialist
JF - HealthEX Specialist
JA - HEALTHEX SPEC
IS - 7
PB - Centor Publishing
AB - Heartlinks is a project which was set up in Merthyr Tydfil in 2002 to examine the effectiveness of using a sports scientist to act as a link between primary care teams and exercise providers. The idea was to try and overcome the principal barriers associated with 'exercise referral' schemes (sportEX health issue 16). The project focussed on sedentary patients identified 'at risk' of coronary heart disease (CHD). Their risk scores are measured and compared pre- and post-intervention using a computer software programme. In addition, the effectiveness of the intervention was evaluated against a range of other measures including physiological changes, general health status, adherence rates and a comparison of referral methodologies. This article summarises the findings to date that already show a number of significant benefits of the project. The findings also provide markers to ensuring more effective exercise referral schemes in the future.
SN - 1744-9375
AD - Principal Public Health Practitioner, National Public Health Service, Wales
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DB - rzh
ER -
TY - JOUR
AU - Clark, Sarah J.
AU - Adolphe, Soukaina
AU - Davis, Matthew M.
AU - Cowan, Anne E.
AU - Kretsinger, Katrina
T1 - Attitudes of US Obstetricians Toward a Combined Tetanus-Diphtheria-Acellular Pertussis Vaccine for Adults.
JO - Infectious Diseases in Obstetrics & Gynecology
JF - Infectious Diseases in Obstetrics & Gynecology
Y1 - 2006/01//
VL - 2006
M3 - Article
SP - 1
EP - 5
PB - Hindawi Publishing Corporation
SN - 10647449
AB - Objective. To describe obstetricians' perspectives related to tetanus-diphtheria-acellular pertussis (Tdap) vaccination of mothers and other adults in close contact with infants. Methods. Mail survey of national random sample of 400 obstetricians . Results. Response rate was 54%. Most respondents would likely recommend Tdap for women during the postpartum hospital stay (78%) or during pregnancy (69%) if a national recommendation was issued. Expected barriers were knowing the date of patients' most recent Td booster (74%) and patient resistance (46%). Most felt that obstetricians have a role in promoting and administering Tdap vaccine to adults other than mothers likely to come in close contact with infants. Conclusion. Obstetricians are likely to agree with the recent provisional US recommendation to administer Tdap to postpartum mothers and other adults expected to come in close contact with infants. Obstetricians would also be likely to support a potential recommendation to administer Tdap during pregnancy. Barriers to adoption of new Tdap vaccine recommendations should be monitored. [ABSTRACT FROM AUTHOR]
AB - Copyright of Infectious Diseases in Obstetrics & Gynecology is the property of Hindawi Publishing Corporation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTETRICIANS
KW - TETANUS
KW - DIPHTHERIA
KW - WHOOPING cough -- Vaccination
KW - BACTERIAL vaccines
KW - MOTHERS
KW - POSTNATAL care
N1 - Accession Number: 28774686; Clark, Sarah J. 1 Adolphe, Soukaina 1,2 Davis, Matthew M. 1,3,4 Cowan, Anne E. 1 Kretsinger, Katrina 5,6; Affiliation: 1: Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, MI 48109, USA 2: Baystate Medical Center, Springfield, MA 01199, USA 3: Division of General Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA 4: Gerald R. Ford School of Public Policy, University of Michigan, Ann Arbor, MI 48109, USA 5: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA 6: Commissioned Corps of the United States Public Health Service, USA; Source Info: 2006, Vol. 2006, p1; Subject Term: OBSTETRICIANS; Subject Term: TETANUS; Subject Term: DIPHTHERIA; Subject Term: WHOOPING cough -- Vaccination; Subject Term: BACTERIAL vaccines; Subject Term: MOTHERS; Subject Term: POSTNATAL care; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1155/IDOG/2006/87040
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joong-Ho Kwon
AU - Young-Hui Choi
AU - Hyung-Wook Chung
AU - Gee-Dong Lee
T1 - The characteristics of a microwave extraction process used for saikosaponins from Bupleurum falcatum root.
JO - International Journal of Food Science & Technology
JF - International Journal of Food Science & Technology
Y1 - 2006/01//
VL - 41
IS - 1
M3 - Article
SP - 67
EP - 75
PB - Wiley-Blackwell
SN - 09505423
AB - The characteristics of a microwave-assisted process (MAPTM) for extraction of saikosaponins from Bupleurum falcatum root were monitored, predicted and optimized through response surface methodology. The maximum yield of total extract was 27.3% when using 102.1 W of microwave power, 54.3% ethanol concentration and extraction for 8.34 min. The extraction patterns for the individual saikosaponins a, c and d showed apparent differences in their response surfaces depending on the process conditions. The maximized extractable contents of saikosaponins a, c and d were predicted, respectively, to be 4.54, 0.45 and 7.31 mg g−1 under the respective conditions of 46.4, 40.7 and 117.2 W of microwave power, 34.7, 47.1 and 67.9% ethanol concentration, and extraction times of 8.0, 7.9 and 3.4 min. A comparison between the predicted and observed values for optimizing the extraction conditions resulted in insignificant differences. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Food Science & Technology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAPONINS
KW - BUPLEURUM
KW - ROOTS (Botany)
KW - MICROWAVES
KW - EXTRACTION (Chemistry)
KW - FOOD industry
KW - Ethanol concentration
KW - microwave-assisted extraction
KW - optimization
KW - response surface methodology
KW - selectivity
N1 - Accession Number: 20754193; Joong-Ho Kwon 1; Email Address: jhkwon@knu.ac.kr Young-Hui Choi 1 Hyung-Wook Chung 2 Gee-Dong Lee 3; Affiliation: 1: Department of Food Science and Technology, Kyungpook National University, Daegu 701-702, Korea 2: Korea Food and Drug Administration, Seoul 121-020, Korea 3: Traditional Bio-Materials Industry Center, Daegu New Technology Agency, Daegu 704-230, Korea; Source Info: Jan2006, Vol. 41 Issue 1, p67; Subject Term: SAPONINS; Subject Term: BUPLEURUM; Subject Term: ROOTS (Botany); Subject Term: MICROWAVES; Subject Term: EXTRACTION (Chemistry); Subject Term: FOOD industry; Author-Supplied Keyword: Ethanol concentration; Author-Supplied Keyword: microwave-assisted extraction; Author-Supplied Keyword: optimization; Author-Supplied Keyword: response surface methodology; Author-Supplied Keyword: selectivity; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2621.2005.01037.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fone, David L.
AU - Christie, Stephen
AU - Lester, Nathan
T1 - Comparison of perceived and modelled geographical access to accident and emergency departments: a cross-sectional analysis from the Caerphilly Health and Social Needs Study.
JO - International Journal of Health Geographics
JF - International Journal of Health Geographics
Y1 - 2006/01//
VL - 5
M3 - Article
SP - 16
EP - 10
PB - BioMed Central
SN - 1476072X
AB - Background: Assessment of the spatial accessibility of hospital accident and emergency departments as perceived by local residents has not previously been investigated. Perceived accessibility may affect where, when, and whether potential patients attend for treatment. Using data on 11,853 respondents to a population survey in Caerphilly county borough, Wales, UK, we present an analysis comparing the accessibility of accident and emergency departments as reported by local residents and drive-time to the nearest accident and emergency department modelled using a geographical information system (GIS). Results: Median drive-times were significantly shorter in the lowest perceived access category and longer in the best perceived access category (p < 0.001). The perceived access and GIS modelled drive-time variables were positively correlated (Spearman's rank correlation coefficient, r = 0.38, p < 0.01). The strongest correlation was found for respondents living in areas in which nearly all households had a car or van (r = 0.47, p < 0.01). Correlations were stronger among respondents reporting good access to public transport and among those reporting a recent accident and emergency attendance for injury treatment compared to other respondents. Correlation coefficients did not vary substantially by levels of household income. Drive-time, road distance and straight-line distance were highly inter-correlated and substituting road distance or straight-line distance as the GIS modelled spatial accessibility measure only marginally decreased the magnitude of the correlations between perceived and GIS modelled access. Conclusion: This study provides evidence that the accessibility of hospital-based health care services as perceived by local residents is related to measures of spatial accessibility modelled using GIS. For studies that aim to model geographical separation in a way that correlates well with the perception of local residents, there may be minimal advantage in using sophisticated measures. Straight-line distance, which can be calculated without GIS, may be as good as GIS-modelled drivetime or distance for this purpose. These findings will be of importance to health policy makers and local planners who seek to obtain local information on access to services through focussed assessments of residents' concerns over accessibility and GIS modelling. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Health Geographics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH services accessibility
KW - EMERGENCY medical services
KW - HOSPITAL emergency services
KW - GEOGRAPHIC information systems
KW - CAERPHILLY (Wales)
KW - WALES
N1 - Accession Number: 28775178; Fone, David L. 1,2; Email Address: foned@cf.ac.uk Christie, Stephen 3; Email Address: stephen.christie012@msd.govt.nz Lester, Nathan 4; Email Address: nathan.lester@nphs.wales.nhs.uk; Affiliation: 1: Department of Epidemiology, Statistics and Public Health, Centre for Health Sciences Research, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4YS, UK 2: National Public Health Service for Wales, Mamhilad Park Estate, Pontypool, Gwent, NP4 0YP, UK 3: Centre for Social Research and Evaluation, Ministry of Social Development, Bowen State Building, Bowen Street, PO Box 1556, Wellington, New Zealand 4: National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, CF10 3NW, UK; Source Info: 2006, Vol. 5, p16; Subject Term: HEALTH services accessibility; Subject Term: EMERGENCY medical services; Subject Term: HOSPITAL emergency services; Subject Term: GEOGRAPHIC information systems; Subject Term: CAERPHILLY (Wales); Subject Term: WALES; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 10p; Illustrations: 2 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1476-072X-5-16
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, B. Sue
AU - Hoskins, Richard E.
AU - Pickle, Linda Williams
AU - Wartenberg, Daniel
T1 - Current practices in spatial analysis of cancer data: mapping health statistics to inform policymakers and the public.
JO - International Journal of Health Geographics
JF - International Journal of Health Geographics
Y1 - 2006/01//
VL - 5
M3 - Article
SP - 49
EP - 14
PB - BioMed Central
SN - 1476072X
AB - Background: To communicate population-based cancer statistics, cancer researchers have a long tradition of presenting data in a spatial representation, or map. Historically, health data were presented in printed atlases in which the map producer selected the content and format. The availability of geographic information systems (GIS) with comprehensive mapping and spatial analysis capability for desktop and Internet mapping has greatly expanded the number of producers and consumers of health maps, including policymakers and the public. Because health maps, particularly ones that show elevated cancer rates, historically have raised public concerns, it is essential that these maps be designed to be accurate, clear, and interpretable for the broad range of users who may view them. This article focuses on designing maps to communicate effectively. It is based on years of research into the use of health maps for communicating among public health researchers. Results: The basics for designing maps that communicate effectively are similar to the basics for any mode of communication. Tasks include deciding on the purpose, knowing the audience and its characteristics, choosing a media suitable for both the purpose and the audience, and finally testing the map design to ensure that it suits the purpose with the intended audience, and communicates accurately and effectively. Special considerations for health maps include ensuring confidentiality and reflecting the uncertainty of small area statistics. Statistical maps need to be based on sound practices and principles developed by the statistical and cartographic communities. Conclusion: The biggest challenge is to ensure that maps of health statistics inform without misinforming. Advances in the sciences of cartography, statistics, and visualization of spatial data are constantly expanding the toolkit available to mapmakers to meet this challenge. Asking potential users to answer questions or to talk about what they see is still the best way to evaluate the effectiveness of a specific map design. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Health Geographics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - SPATIAL analysis (Statistics)
KW - CLUSTER analysis (Statistics)
KW - GEOGRAPHIC information systems
KW - MEDICAL mapping
KW - PUBLIC health
KW - MEDICAL geography
N1 - Accession Number: 28775208; Bell, B. Sue 1; Email Address: sue.bell@fda.hhs.gov Hoskins, Richard E. 2; Email Address: richard.hoskins@doh.wa.gov Pickle, Linda Williams 3; Email Address: picklel@mail.nih.gov Wartenberg, Daniel 4; Email Address: dan.wartenberg@umdnj.edu; Affiliation: 1: U.S. Food and Drug Administration, 5600 Fishers Lane Rm 15-62 HFP-20, Rockville, MD 20857, USA 2: Comprehensive Cancer Control Program, Washington State Department of Health,111 Israel Road, PO Box 47855, Olympia, WA 98504-7855, USA 3: Division of Cancer Control and Population Sciences, National Cancer Institute, 6116 Executive Boulevard, Suite 504, Bethesda, MD 20892, USA 4: Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 170, Frelinghuysen Road, Piscataway, NJ 08854, USA; Source Info: 2006, Vol. 5, p49; Subject Term: CANCER; Subject Term: SPATIAL analysis (Statistics); Subject Term: CLUSTER analysis (Statistics); Subject Term: GEOGRAPHIC information systems; Subject Term: MEDICAL mapping; Subject Term: PUBLIC health; Subject Term: MEDICAL geography; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 14p; Illustrations: 5 Color Photographs; Document Type: Article
L3 - 10.1186/1476-072X-5-49
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28775208&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106423256
T1 - Malignant mesothelioma mortality in the United States, 1999-2001.
AU - Bang KM
AU - Pinheiro GA
AU - Wood JM
AU - Syamlal G
Y1 - 2006/01//2006 Jan-Mar
N1 - Accession Number: 106423256. Language: English. Entry Date: 20060407. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Mesothelioma -- Mortality -- United States
KW - Occupational Diseases -- Mortality -- United States
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Data Analysis Software
KW - Disease Surveillance
KW - Epidemiological Research
KW - Female
KW - Geographic Factors
KW - Male
KW - Middle Age
KW - Occupational Exposure
KW - United States
KW - Human
SP - 9
EP - 15
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 12
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Malignant mesothelioma is strongly associated with asbestos exposure. This paper describes demographic, geographic, and occupational distributions of mesothelioma mortality in the United States, 1999-2001. The data (n = 7,524) were obtained from the National Center for Health Statistics multiple-cause-of-death records. Mortality rates (per million per year) were age-adjusted to the 2000 U.S. standard population, and proportionate mortality ratios (PMRs) were calculated by occupation and industry, and adjusted for age, sex, and race. The overall age-adjusted mortality rate was 11.52, with males (22.34) showing a sixfold higher rate than females (3.94). Geographic distribution of mesothelioma mortality is predominantly coastal. Occupations with significantly elevated PMRs included plumbers/pipefitters and mechanical engineers. Industries with significantly elevated PMRs included ship and boat building and repairing, and industrial and miscellaneous chemicals. These surveillance findings can be useful in generating hypotheses and developing strategies to prevent mesothelioma.
SN - 1077-3525
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505
U2 - PMID: 16523977.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cherstniakova, Svetlana A.
AU - Garcia, Gregory E.
AU - Strong, John
AU - Daoqin Bi
AU - Weitz, Julie
AU - Roy, Michael J.
AU - Cantilena, Louis R.
T1 - Rapid Determination of N,N-Diethyl-m-Toluamide and Permethrin in Human Plasma by Gas Chromatography—Mass Spectrometry and Pyridostigmine Bromide by High-Performance Liquid Chromatography.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 2006/01//Jan/Feb2006
VL - 30
IS - 1
M3 - Article
SP - 21
EP - 26
SN - 01464760
AB - The article describes a rapid and highly sensitive gas chromatography-mass spectrometry (GC-MS) method for simultaneous determination of N,N-diethyl-m-toluamide (DEET) and permethrin with 2H10- phenanthrene as an internal standard and a separate external standard high-performance liquid chromatography (HPLC) method for pyridostigmine bromide (PB) determination in human plasma. The GC-MS method for DEET and permethrin quantification utilizes a one-step extraction with tert-butylmethylether. The HPLC method for PB quantification involves a solid-phase extraction and ultraviolet detection. Both methods were successfully applied to pharmacokinetic/pharmacodynamic studies of combined exposure of DEET, permethrin and PB in healthy volunteers.
KW - INSECT baits & repellents
KW - INSECTICIDES
KW - GAS chromatography
KW - MASS spectrometry
KW - PYRIDOSTIGMINE bromide
KW - BLOOD plasma
KW - HIGH performance liquid chromatography
N1 - Accession Number: 19580258; Cherstniakova, Svetlana A. 1 Garcia, Gregory E. 2 Strong, John 3 Daoqin Bi 1 Weitz, Julie 1 Roy, Michael J. 1 Cantilena, Louis R. 1; Email Address: IcantiIena@usuhs.mil; Affiliation: 1: Division of Clinical Pharmacology and Medical Toxicology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 2: Walter Reed Army Institute of Research, Silver Spring, Maryland 3: Laboratory of Clinical Pharmacology, Center for Drug Evaluation, U0S. Food and Drug Administration, Rockville, Maryland; Source Info: Jan/Feb2006, Vol. 30 Issue 1, p21; Subject Term: INSECT baits & repellents; Subject Term: INSECTICIDES; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: PYRIDOSTIGMINE bromide; Subject Term: BLOOD plasma; Subject Term: HIGH performance liquid chromatography; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yeon-Joon Park
AU - Seungok Lee
AU - Yang Ree Kim
AU - Eun-Jee Oh
AU - Gun-Jo Woo
AU - Kyungwon Lee
T1 - Occurrence of extended-spectrum -lactamases and plasmid-mediated AmpC -lactamases among Korean isolates of Proteus mirabilis.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2006/01//
VL - 57
IS - 1
M3 - Article
SP - 156
EP - 158
SN - 03057453
N1 - Accession Number: 19393762; Yeon-Joon Park 1; Seungok Lee 2; Yang Ree Kim 3; Eun-Jee Oh 4; Gun-Jo Woo 5; Kyungwon Lee 6; Affiliations: 1: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Korea;; 2: Seoul Medical Science Institute, Seoul Clinical Laboratories, Seoul, Korea;; 3: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea;; 4: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Korea;; 5: Korea Food and Drug Administration, Seoul, Korea;; 6: Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea; Issue Info: Jan2006, Vol. 57 Issue 1, p156; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cieri, Ugo R.
T1 - Determination of Phenylephrine Hydrochloride, Chiorpheniramine Maleate, and Methscopolamine Nitrate in Tablets or Capsules by Liquid Chromatography with Two UV Absorbance Detectors in Series.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 53
EP - 58
SN - 10603271
AB - The article focuses on the development of a method for the simultaneous determination of phenylephrine hydrochloride, chiorpheniramine maleate, and methscopolamine nitrate in commercial tablets and capsules using liquid chromatography. The procedure evaluated the significant quantity of the said compounds present in the samples. These compounds present on commercial drugs can be used for the relief of respiratory congestion, allergic or vasomotor rhinitis, and skin allergies.
KW - DRUGS -- Analysis
KW - LIQUID chromatography
KW - TABLETS (Medicine)
KW - CHROMATOGRAPHIC analysis
KW - BIOACTIVE compounds
KW - SOLID dosage forms
N1 - Accession Number: 19965926; Cieri, Ugo R. 1; Email Address: ucieri@ora.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 2nd and Chestnut Sts, Philadelphia, PA 19106; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p53; Subject Term: DRUGS -- Analysis; Subject Term: LIQUID chromatography; Subject Term: TABLETS (Medicine); Subject Term: CHROMATOGRAPHIC analysis; Subject Term: BIOACTIVE compounds; Subject Term: SOLID dosage forms; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blougett, Robert J.
T1 - Testing Deviation for a Set of Serial Dilution Most Probable Numbers from a Poisson-Binomial Model.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 166
EP - 171
SN - 10603271
AB - The article focuses on a serial dilution experiment on microbial concentration in a broth using a Poisson-binomial model. In the study, several sets of tubes with various amounts of the broth were inoculated. It was found that factors including interfering microbes, toxins, or disaggregation of adhering microbes may distort the result of the said experiment.
KW - DILUTION
KW - FOOD -- Microbiology
KW - POISSON distribution
KW - QUALITATIVE chemical analysis
KW - MICROBIAL toxins
KW - MICROORGANISMS -- Adhesion
KW - CHEMICAL reactions
N1 - Accession Number: 19965941; Blougett, Robert J. 1; Email Address: rblodget@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p166; Subject Term: DILUTION; Subject Term: FOOD -- Microbiology; Subject Term: POISSON distribution; Subject Term: QUALITATIVE chemical analysis; Subject Term: MICROBIAL toxins; Subject Term: MICROORGANISMS -- Adhesion; Subject Term: CHEMICAL reactions; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duvall, Robert E.
AU - Eklund, Marjut
AU - Tran, Tony T.
AU - Hitchins, Anthony D.
T1 - Improved DNA Probe Detection of Listeria monocytogenes in Enrichment Culture After Physical-Chemical Fractionation.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 172
EP - 179
SN - 10603271
AB - The article presents a study of the effect of enrichment time and competitive microflora on the interfacing of Listeria monocytogenes specific test kit with the U.S. Food and Drug Administration Bacteriological Analytical Manual. Various methods including selective enrichments, selective isolation, and isolate purification were introduced. The study showed that the kit is adaptable to Listeria enrichment broth cultures with suitable enrichment culture processing.
KW - LISTERIA monocytogenes
KW - MICROBIAL sensitivity tests
KW - MICROBIOLOGY -- Technique
KW - FOOD -- Microbiology
KW - BACTERIOLOGY
KW - LABORATORY manuals
KW - UNITED States
N1 - Accession Number: 19965942; Duvall, Robert E. 1 Eklund, Marjut 1 Tran, Tony T. 1 Hitchins, Anthony D. 1; Email Address: Anthony.Hitchkins@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-5 16, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p172; Subject Term: LISTERIA monocytogenes; Subject Term: MICROBIAL sensitivity tests; Subject Term: MICROBIOLOGY -- Technique; Subject Term: FOOD -- Microbiology; Subject Term: BACTERIOLOGY; Subject Term: LABORATORY manuals; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hammack, Thomas S.
AU - Johnson, Mildred L.
AU - Jacobson, Andrew P.
AU - Andrews, Wallace H.
T1 - Effect of Sample Preparation and Preenrichment Media on the Recovery of Salmonella from Cantaloupes, Mangoes, and Tomatoes.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 180
EP - 184
SN - 10603271
AB - The article presents a study of the effect of buffered peptone water, lactose broth, and Universal Preenrichment broth on the recovery of Salmonella organisms from fruits. The fruits studied include mangoes, cantaloupes, and tomatoes. Analyses revealed that the soak method significantly produce greater number of positive test on Salmonella presence.
KW - SALMONELLA
KW - FOOD -- Microbiology
KW - MICROBIOLOGICAL research
KW - ENTEROBACTERIACEAE
KW - PEPTONES
KW - LACTOSE products
N1 - Accession Number: 19965943; Hammack, Thomas S. 1; Email Address: Thomas.Hammack@fda.hhs.gov Johnson, Mildred L. 1 Jacobson, Andrew P. 1 Andrews, Wallace H. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Microbiological Studies, College Park, MD 20740; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p180; Subject Term: SALMONELLA; Subject Term: FOOD -- Microbiology; Subject Term: MICROBIOLOGICAL research; Subject Term: ENTEROBACTERIACEAE; Subject Term: PEPTONES; Subject Term: LACTOSE products; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hepp, Nancy M.
T1 - Determination of Mercury in Carbon Black by Cold Vapor Atomic Absorption Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 192
EP - 195
SN - 10603271
AB - The article discusses the method of determining mercury in D&C Black No. 2, a high-purity furnace black by cold vapor Atomic Absorption Spectrometry (AAS). This color additive was subject to certification by the U.S. Food and Drug Administration (FDA) based on its Hg content. Carbon black samples were treated with a mixture of nitric and hydrochloric acids, then heated and the resulting solutions were diluted and analyzed using cold vapor AAS. Hg content must not more than 1 ppm.
KW - FOOD additives
KW - ADDITIVES
KW - MERCURY
KW - ATOMIC absorption spectroscopy
KW - CARBON
KW - NITRIC acid
KW - HYDROCHLORIC acid
N1 - Accession Number: 19965945; Hepp, Nancy M. 1; Email Address: nhepp@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Office of Cosmetics and Colors, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p192; Subject Term: FOOD additives; Subject Term: ADDITIVES; Subject Term: MERCURY; Subject Term: ATOMIC absorption spectroscopy; Subject Term: CARBON; Subject Term: NITRIC acid; Subject Term: HYDROCHLORIC acid; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 325311 Nitrogenous Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schenck, Frank J.
AU - Podhorniak, Lynda V.
AU - Hobbs, James
AU - Casanova, John
AU - Donoghue, Dan
T1 - Liquid Chromatographic Determination of N-Methyl Carbamate Pesticide Residues at Low Parts-Per-Billion Levels in Eggs.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 196
EP - 200
SN - 10603271
AB - The article discusses the liquid chromatographic (LC) method used in the analysis of N-Methyl carbamate pesticide residues and piperonyl butoxide in eggs at levels as low as 2 µg/kg (ppb). Acetonitrale extraction was used followed by liquid-liquid partitioning and normal-phase aminopropyl solid-extraction column cleanup. Residues will be determined by reversed-phase LC on an inline postcolumn reaction and followed by fluorescence detection.
KW - EGGS
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - METHYL aspartate
KW - CARBAMATES
KW - PESTICIDES
KW - ACETONITRILE
N1 - Accession Number: 19965946; Schenck, Frank J. 1; Email Address: fschenck@ora.fda.gov Podhorniak, Lynda V. 2 Hobbs, James 1 Casanova, John 1 Donoghue, Dan 3; Affiliation: 1: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309 2: U.S. Environmental Protection Agency, Office of Pesticide Programs, 701 Mapes Rd, Fort Meade, MD 20755 3: University of Arkansas, Department of Poultry Science, Fayetteville, AR 72701; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p196; Subject Term: EGGS; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: METHYL aspartate; Subject Term: CARBAMATES; Subject Term: PESTICIDES; Subject Term: ACETONITRILE; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 5p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hungerford, James M.
T1 - Committee on Natural Toxins and Food Allergens.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 248
EP - 269
SN - 10603271
AB - The article discusses symposia on the research of marine toxins in the U.S. These activities conducted by the Marine and Freshwater Toxins Task Force aimed to contribute food safety and care to marine animals. The symposia had focused on shellfish toxins and had devised subgrouping sessions including ciguatoxins, saxitoxins and domoic acids, and liquid chromatography working towards the goal of producing officially validated analytical methods.
KW - CONFERENCES & conventions
KW - MARINE toxins
KW - POISONOUS shellfish
KW - LIQUID chromatography
KW - UNITED States
N1 - Accession Number: 19965954; Hungerford, James M. 1; Email Address: james.Hungerford@fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Seafood Products Research Center, 22201 23rd Dr SE, Bothell, WA 98021, Tel: 425-483-4894, Fax: 425-483-4996; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p248; Subject Term: CONFERENCES & conventions; Subject Term: MARINE toxins; Subject Term: POISONOUS shellfish; Subject Term: LIQUID chromatography; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 22p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, Mary W.
T1 - Mycotoxins.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 270
EP - 284
SN - 10603271
AB - The article discusses the study made by the U.S. Food and Drug Administration relating to mycotoxins. Methods used in 2004 include the determination of Ochratoxin A in Green Coffee by Immunoaffinity Column Cleanup and Liquid Chromatography, and the determination of the same in wine. Sampling and subsampling methods were also introduced by Thomas B. Whitewalker of U.S. Department of Agriculture that detects mycotoxins and other quality attributes in agricultural products.
KW - MYCOTOXINS
KW - OCHRATOXINS
KW - RESEARCH
KW - FARM produce
KW - UNITED States
N1 - Accession Number: 19965955; Trucksess, Mary W. 1; Email Address: mtruckse@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, Tel: 301-436-1957 (office), 301-436-2563 (laboratory), Fax: 301-436-2665; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p270; Subject Term: MYCOTOXINS; Subject Term: OCHRATOXINS; Subject Term: RESEARCH; Subject Term: FARM produce; Subject Term: UNITED States; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 493130 Farm Product Warehousing and Storage; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andrews, Wallace H.
AU - Hammack, Thomas S.
T1 - Committee on Microbiology and Extraneous Materials.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/01//Jan/Feb2006
VL - 89
IS - 1
M3 - Article
SP - 304
EP - 318
SN - 10603271
AB - The article focuses on the methods used in the study of microbiology applied on dairy products in Great Britain. BioControl Assurance Method has been used in detecting "Eschirechia coli"introduced by study director Philip T. Feldsine. This system of study is an automated gene-based that uses proprietary probes and specific primers directed against a highly conserved Deoxyrebosenucleic acid sequence of the said organism.
KW - MICROBIOLOGY
KW - SCIENTIFIC knowledge
KW - MICROORGANISMS
KW - DNA
KW - TECHNOLOGY
KW - GREAT Britain
KW - FELDSINE, Philip T.
N1 - Accession Number: 19965959; Andrews, Wallace H. 1; Email Address: wallace.andrews@cfsan.fda.gov Hammack, Thomas S. 1; Email Address: thomas.hammack@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, Tel: 301-436-2008 (Andrews), 301-436-2010 (Hammack), Fax: 301-436-2644,; Source Info: Jan/Feb2006, Vol. 89 Issue 1, p304; Subject Term: MICROBIOLOGY; Subject Term: SCIENTIFIC knowledge; Subject Term: MICROORGANISMS; Subject Term: DNA; Subject Term: TECHNOLOGY; Subject Term: GREAT Britain; People: FELDSINE, Philip T.; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ge, B.
AU - Girard, W.
AU - Zhao, S.
AU - Friedman, S.
AU - Gaines, S. A.
AU - Meng, J.
T1 - Genotyping of Campylobacter spp. from retail meats by pulsed-field gel electrophoresis and ribotyping.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2006/01//
VL - 100
IS - 1
M3 - Article
SP - 175
EP - 184
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: To determine the genetic relatedness of Campylobacter spp. from retail meat products, and compare the discriminatory power of pulsed-field gel electrophoresis (PFGE) and automatic ribotyping. Methods and Results: A total of 378 Campylobacter isolates recovered from 159 raw meats (130 chicken, 25 turkey, three pork and one beef) sampled from 50 retail grocery stores of four supermarket chains in the Maryland suburban area from August 1999 to July 2000 were analysed by PFGE with SmaI, 120 isolates of which were also characterized by ribotyping with PstI using RiboPrinter® system. A total of 148 unique PFGE patterns were identified, 91 of which were present in multiple Campylobacter isolates and 24 in multiple meat samples. Nineteen Campylobacter clones with identical PFGE patterns recurred frequently (up to nine times) throughout the sampling period. Comparing ribotyping with PFGE, we identified 44 PFGE patterns and 22 RiboGroups among the 120 isolates tested. Multiple PFGE patterns within one RiboGroup were commonly observed, as well as multiple RiboGroups within one PFGE pattern. Conclusions: Although Campylobacter present in retail meats were genetically diverse, certain clones persisted in poultry meats. PFGE had a greater discriminatory power than ribotyping, and the two methods were complementary in genotyping Campylobacter. Significance and Impact of the Study: Genomic DNA fingerprinting of Campylobacter confirmed diverse and recurrent Campylobacter clones in the retail meats, which provides additional data for a better understanding of the epidemiological aspect of Campylobacter infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter
KW - Meat
KW - Bacteria
KW - Electrophoresis
KW - Pulsed-field gel electrophoresis
KW - genotyping
KW - pulsed-field gel electrophoresis
KW - retail meat
KW - ribotyping
N1 - Accession Number: 19398351; Ge, B. 1,2; Girard, W. 1; Zhao, S. 3; Friedman, S. 3; Gaines, S. A. 3; Meng, J. 1; Email Address: jmeng@umd.edu; Affiliations: 1: Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; 2: Department of Food Science, Louisiana State University, Baton Rouge, LA, USA; 3: Division of Animal and Food Microbiology/Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA; Issue Info: Jan2006, Vol. 100 Issue 1, p175; Thesaurus Term: Campylobacter; Thesaurus Term: Meat; Thesaurus Term: Bacteria; Subject Term: Electrophoresis; Subject Term: Pulsed-field gel electrophoresis; Author-Supplied Keyword: genotyping; Author-Supplied Keyword: pulsed-field gel electrophoresis; Author-Supplied Keyword: retail meat; Author-Supplied Keyword: ribotyping; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 445210 Meat Markets; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1365-2672.2005.02750.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Won-Sun Yang
AU - Hye-Won Roh
AU - Won Kyu Lee
AU - Gyu Ha Ryu
T1 - Evaluation of functions and tissue compatibility of poly (D,L-lactic-co-glycolic acid) seeded with human dermal fibroblasts.
JO - Journal of Biomaterials Science -- Polymer Edition
JF - Journal of Biomaterials Science -- Polymer Edition
Y1 - 2006/01//
VL - 17
IS - 1/2
M3 - Article
SP - 151
EP - 162
PB - Taylor & Francis Ltd
SN - 09205063
AB - In tissue engineering and wound-healing applications, dermal substitutes are used to provide fibroblasts with the mechanical support for their growth and then to facilitate the skin formation. In this study, three-dimensional porous poly(lactic-co-glycolic acid) (PLGA) 65/35 scaffolds were prepared and then the composites of the scaffolds and human fetal dermal fibroblasts were fabricated as a tissue-engineered dermal substitute. The function and tissue compatibility of the artificial dermal substitute were evaluated at the levels of gene expression (by RT-PCR) and protein expression (total collagen quantities), as well as by histological and immunohistochemical analysis. The PCR products indicated that the mRNA of type-I collagen, mainly secreted by the fibroblasts onto the PLGA scaffolds, was clearly expressed after 4 weeks. The amount of total collagen synthesized from the cells was shown to increase gradually during the initial culture period and slightly decreased afterwards. After 8 weeks of culture, the fibroblasts were well attached and migrated entirely throughout the pores of the PLGA scaffold with normal function. Furthermore, the positively stained type-I collagen was intensively detected throughout the pores. These results suggest that the function and tissue compatibility may be important criteria in evaluating an artificial tissue-engineered skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONNECTIVE tissue cells
KW - TISSUE engineering
KW - EXTRACELLULAR matrix proteins
KW - CONNECTIVE tissues
KW - FIBROBLASTS
KW - GENE expression
KW - GENETIC regulation
KW - MESSENGER RNA
KW - BIOMEDICAL engineering
KW - TISSUE culture
KW - COLLAGEN SYNTHESIS
KW - human dermal fibroblasts
KW - PLGA SCAFFOLDS
KW - TISSUE COMPATIBILITY
KW - tissue compatibility.
KW - TISSUE-ENGINEERED SKIN
N1 - Accession Number: 19064360; Won-Sun Yang 1 Hye-Won Roh 1 Won Kyu Lee 1 Gyu Ha Ryu 1; Email Address: gyuha@kfda.go.kr; Affiliation: 1: Department of Medical Devices and Radiation Health, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, South Korea; Source Info: Jan2006, Vol. 17 Issue 1/2, p151; Subject Term: CONNECTIVE tissue cells; Subject Term: TISSUE engineering; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: CONNECTIVE tissues; Subject Term: FIBROBLASTS; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: MESSENGER RNA; Subject Term: BIOMEDICAL engineering; Subject Term: TISSUE culture; Author-Supplied Keyword: COLLAGEN SYNTHESIS; Author-Supplied Keyword: human dermal fibroblasts; Author-Supplied Keyword: PLGA SCAFFOLDS; Author-Supplied Keyword: TISSUE COMPATIBILITY; Author-Supplied Keyword: tissue compatibility.; Author-Supplied Keyword: TISSUE-ENGINEERED SKIN; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 12p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1163/156856206774879108
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reuter, Gábor
AU - Vennema, Harry
AU - Koopmans, Marion
AU - Szücs, György
T1 - Epidemic spread of recombinant noroviruses with four capsid types in Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006/01//
VL - 35
IS - 1
M3 - Article
SP - 84
EP - 88
SN - 13866532
AB - Abstract: Background: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. Objectives: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. Study design: From January 2001 to May 2004, samples containing “GGIIb/Hilversum polymerase” (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. Results: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n =9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n =6, 28%), Hu/NLV/GGII/Hawaii/1971 (n =4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n =1, 5%). Conclusions: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants—next to GGII-4/Lordsdale virus—causing epidemics of gastroenteritis in the last 4 years. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS
KW - PATHOGENIC microorganisms
KW - WATERBORNE infection
KW - FOODBORNE diseases
KW - COMMUNICABLE diseases -- Transmission
KW - POLYMERASE chain reaction
KW - EUROPE
KW - Emerging
KW - genogroup ( GG )
KW - Norovirus
KW - Norwalk-like viruses ( NLV )
KW - open reading frame ( ORF )
KW - Outbreaks of gastroenteritis
KW - phosphate buffered saline ( PBS )
KW - Recombinant
KW - reverse transcription-polymerase chain reaction ( RT-PCR )
KW - ribonucleic acid ( RNA )
N1 - Accession Number: 19340672; Reuter, Gábor 1,2; Email Address: reuterg@baranya.antsz.hu Vennema, Harry 2 Koopmans, Marion 2 Szücs, György 1; Affiliation: 1: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság ut 7, H-7623 Pécs, Hungary 2: Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, RIVM National Institute for Public Health and the Environment, A. van Leewenhoeklaan 9, Bilthoven, The Netherlands; Source Info: Jan2006, Vol. 35 Issue 1, p84; Subject Term: GASTROENTERITIS; Subject Term: PATHOGENIC microorganisms; Subject Term: WATERBORNE infection; Subject Term: FOODBORNE diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: POLYMERASE chain reaction; Subject Term: EUROPE; Author-Supplied Keyword: Emerging; Author-Supplied Keyword: genogroup ( GG ); Author-Supplied Keyword: Norovirus; Author-Supplied Keyword: Norwalk-like viruses ( NLV ); Author-Supplied Keyword: open reading frame ( ORF ); Author-Supplied Keyword: Outbreaks of gastroenteritis; Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: Recombinant; Author-Supplied Keyword: reverse transcription-polymerase chain reaction ( RT-PCR ); Author-Supplied Keyword: ribonucleic acid ( RNA ); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jcv.2005.07.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Michael J.
AU - Yancy, Haile F.
AU - Araneta, Michael
AU - Armour, Jennifer
AU - Derr, Janice
AU - Hoostelaere, Lawrence A. D.
AU - Farmer, Doris
AU - Jackson, Falana
AU - Kiessling, William M.
AU - Koch, Henry
AU - Huahua Lin
AU - Yan Liu
AU - Mowlds, Gabrielle
AU - Pinero, David
AU - Riter, Ken L.
AU - Sedwick, John
AU - Yuelian Shen
AU - Wetherington, June
AU - Younkins, Ronsha
T1 - Validation of a PCR-Based Method for the Detection of Various Rendered Materials in Feedstutts Using a Forensic DNA Extraction Kit.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/01//
VL - 69
IS - 1
M3 - Article
SP - 205
EP - 210
SN - 0362028X
AB - A method trial was initiated to validate the use of a commercial DNA forensic kit to extract DNA from animal feed as part of a PCR-based method. Four different PCR primer pairs (one bovine pair, one porcine pair, one ovine primer pair, and one multispecies pair) were also evaluated. Each laboratory was required to analyze a total of 120 dairy feed samples either not fortified (control, true negative) or fortified with bovine meat and bone meal, porcine meat and bone meal (PMBM), or lamb meal. Feeds were fortified with the animal meals at a concentration of 0.1% (wt/wt). Ten laboratories participated in this trial, and each laboratory was required to evaluate two different primer pairs, i.e., each PCR primer pair was evaluated by five different laboratories. The method was considered to be validated for a given animal source when three or more laboratories achieved at least 97% accuracy (29 correct of 30 samples for 96.7% accuracy, rounded up to 97%) in detecting the fortified samples for that source. Using this criterion, the method was validated for the bovine primer because three laboratories met the criterion, with an average accuracy of 98.9%. The average false-positive rate was 3.0% in these laboratories. A fourth laboratory was 80% accurate in identifying the samples fortified with bovine meat and bone meal. A fifth laboratory was not able to consistently extract the DNA from the feed samples and did not achieve the criterion for accuracy for either the bovine or multispecies PCR primers. For the porcine primers, the method was validated, with four laboratories meeting the criterion for accuracy with an average accuracy of 99.2%. The fifth laboratory had a 93.3% accuracy outcome for the porcine primer. Collectively, these five laboratories had a 1.3% false-positive rate for the porcine primer. No laboratory was able to meet the criterion for accuracy with the ovine primers, most likely because of problems with the synthesis of the primer pair; none of the positive control DNA samples could be detected with the ovine primers. The multispecies primer pair was validated in three laboratories for use with bovine meat and bone meal and lamb meal but not with PMBM. The three laboratories had an average accuracy of 98.9% for bovine meat and bone meal, 97.8% for lamb meal, and 63.3% for PMBM. When examined on an individual laboratory basis, one of these four laboratories could not identify a single feed sample containing PMBM by using the multispecies primer, whereas the other laboratory identified only one PMBM-fortified sample, suggesting that the limit of detection for PMBM with this primer pair is around 0.1% (wt/wt). The results of this study demonstrated that the DNA forensic kit can be used to extract DNA from animal feed, which can then be used for PCR analysis to detect animal-derived protein present in the feed sample. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Feeds
KW - HEALTH
KW - Research
KW - DNA
KW - Porcine reproductive & respiratory syndrome
KW - Cattle
KW - Forensic sciences
N1 - Accession Number: 19441269; Myers, Michael J. 1; Email Address: mmyers@cvm.fda.gov.; Yancy, Haile F. 1; Araneta, Michael 2; Armour, Jennifer 3; Derr, Janice 4,5; Hoostelaere, Lawrence A. D. 6; Farmer, Doris 7; Jackson, Falana 8; Kiessling, William M. 7; Koch, Henry 9; Huahua Lin 10; Yan Liu 11; Mowlds, Gabrielle 12; Pinero, David 13; Riter, Ken L. 10; Sedwick, John 2; Yuelian Shen 11; Wetherington, June 12; Younkins, Ronsha 14; Affiliations: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, Maryland 20708, USA; 2: U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Region Laboratory&Southwest, Irvine, California 92612, USA; 3: Canadian Food Inspection Agency, Ottawa, Ontario, Canada KIA 0C6; 4: U.S. Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland 20855, USA; 5: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Rockville, MD 20852, USA; 6: U. S. Food and Drug Administration, Office of Regulatory Affairs, Division of Field Sciences, Rockville, Maryland 20857, USA; 7: U.S. Food and Drug Administration, Office of Regulatory Affairs, Denver Regional Laboratory, Denver, Colorado 80225, USA; 8: U.S. Food and Drug Administration, Office of Regulatory Affairs, Arkansas Regional Laboratory, Jefferson, Arkansas 72079, USA; 9: U.S. Food and Drug Administration, Office of Regulatory Affairs, Northeast Regional Laboratory, Jamaica, New York 11433, USA; 10: Office of the Indiana State Chemist, West Lafayette, Indiana 47907, USA; 11: Florida State Department of Agriculture, Tallahassee, Florida 32399, USA; 12: U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Region Laboratory&Northwest, Bothell, Washington 98021, USA; 13: Eurofins Scientific, Inc., Des Moines, Iowa 50313, USA; 14: U.S. Food and Drug Administration, Office of Regulatory Affairs, Southeast Regional Laboratory, Atlanta, Georgia 30309, USA; Issue Info: Jan2006, Vol. 69 Issue 1, p205; Thesaurus Term: Feeds; Thesaurus Term: HEALTH; Thesaurus Term: Research; Subject Term: DNA; Subject Term: Porcine reproductive & respiratory syndrome; Subject Term: Cattle; Subject Term: Forensic sciences; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vij, Vibha
AU - Ailes, Elizabeth
AU - Wolyniak, Cecilia
AU - Angulo, Frederick J.
AU - Klontz, Karl C.
T1 - Recalls of Spices Due to Bacterial Contamination Monitored by the U.S. Food and Drug Administration: The Predominance of Salmonellae.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/01//
VL - 69
IS - 1
M3 - Article
SP - 233
EP - 237
SN - 0362028X
AB - From 1980 to 2000, the annual per capita consumption of spices in the United States increased by 60% (from 1.0 to 1.6 kg per person per year). Although spices are known to harbor various molds, fungi, and bacteria, relatively few reports have documented this group of foods as the cause of human illness. In recent years, however, the U.S. Food and Drug Administration (FDA) has noted an increased number of recalls of dried spices due to bacterial contamination. Accordingly, we reviewed spice recalls that took place in the United States from fiscal years 1970 to 2003. During the study period, the FDA monitored 21 recalls involving 12 spice types contaminated with bacterial pathogens; in all but one instance, the recalled spices contained Salmonella. Paprika was the spice most often involved in the recalls. A wide variety of countries were the source of the recalled spices. Using data from the Centers for Disease Control and Prevention National Salmonella Surveillance System, we were unable to discern any increases in the reported incidence of laboratory-confirmed salmonellosis in states that received spices contaminated with selected rare Salmonella serotypes. A variety of effective methods exist to disinfect spices, procedures that have attained increased importance given the frequent use of spices in ready-to-eat foods and the potential for contaminated spices to cause widespread outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food poisoning
KW - Food contamination
KW - Food pathogens
KW - Foodborne diseases
KW - Bacterial antigens
KW - Salmonella
KW - United States
N1 - Accession Number: 19441275; Vij, Vibha 1; Ailes, Elizabeth 2,3; Wolyniak, Cecilia 4; Angulo, Frederick J. 2; Klontz, Karl C. 4; Email Address: karl.klontz@cfsan.fda.gov; Affiliations: 1: George Washington University School of Public Health and Health Services, Washington, D. C. 20052; 2: Foodborne & Diarrheal Disease Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; 3: Atlanta Research and Education Foundation, Atlanta, Georgia 30333; 4: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20814, USA; Issue Info: Jan2006, Vol. 69 Issue 1, p233; Thesaurus Term: Food poisoning; Thesaurus Term: Food contamination; Thesaurus Term: Food pathogens; Thesaurus Term: Foodborne diseases; Thesaurus Term: Bacterial antigens; Thesaurus Term: Salmonella; Subject: United States; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - RPRT
AU - Epstein, Suzanne L.
T1 - Prior H1N1 Influenza Infection and Susceptibility of Cleveland Family Study Participants during the H2N2 Pandemic of 1957: An Experiment of Nature.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/01//1/1/2006
VL - 193
IS - 1
M3 - Report
SP - 49
EP - 53
SN - 00221899
AB - During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 5 5.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA
KW - EPIDEMIOLOGY
KW - COMMUNICABLE diseases
KW - IMMUNOGLOBULINS
KW - IMMUNITY
KW - MEDICAL research
N1 - Accession Number: 19262257; Epstein, Suzanne L. 1; Email Address: epsteins@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland.; Source Info: 1/1/2006, Vol. 193 Issue 1, p49; Subject Term: INFLUENZA; Subject Term: EPIDEMIOLOGY; Subject Term: COMMUNICABLE diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNITY; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Report
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sabharwal, Hemant
AU - Michon, Francis
AU - Nelson, Daniel
AU - Dong, Wenling
AU - Fuchs, Kathleen
AU - Carreño^Manjarrez, Roberto
AU - Sarkar, Arun
AU - Uitz, Catherine
AU - Viteri-Jackson, Ann
AU - Suarez, Romeo S. Rodriguez
AU - Blake, Milan
AU - Zabriskie, John B.
T1 - Group A Streptococcus (GAS) Carbohydrate as an Immunogen for Protection against GAS Infection.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/01//1/1/2006
VL - 193
IS - 1
M3 - Article
SP - 129
EP - 135
SN - 00221899
AB - Previous studies have shown that human serum containing anti-group A streptococcus carbohydrate (GAS CHO) antibodies were opsonic for different M protein-carrying serotypes. To investigate the role that anti GAS CHO antibodies play in passive and active protection, mice were immunized subcutaneously or intra- nasally with GAS CHO conjugated to tetanus toxoid, and mortality and oral colonization were monitored after challenge with live GAS. Compared with control mice, immunized mice were significantly protected against systemic or nasal challenge with GAS. Furthermore, studies of serum samples and throat cultures from Mexican children revealed an inverse relationship between high serum titers of anti-GAS CHO antibodies and the presence of GAS in the throat. Anti-GAS CHO antibodies were also tested for cross-reactivity with human tissues and cytoskeletal proteins. No cross-reactivity was observed in either assay. The present study demonstrates that GAS CHO is both immunogenic and protective against GAS infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STREPTOCOCCUS
KW - IMMUNOGLOBULINS
KW - SERUM
KW - MORTALITY
KW - PROTEINS
KW - DEMOGRAPHY
N1 - Accession Number: 19262267; Sabharwal, Hemant 1,2; Email Address: sabharwalh@hss.edu Michon, Francis 3 Nelson, Daniel 4 Dong, Wenling 3 Fuchs, Kathleen 2 Carreño^Manjarrez, Roberto 5 Sarkar, Arun 3 Uitz, Catherine 3 Viteri-Jackson, Ann 1 Suarez, Romeo S. Rodriguez 6 Blake, Milan 7 Zabriskie, John B. 1,2; Affiliation: 1: Research Division, Hospital for Special Surgery, Rockefeller University, New York, New York. 2: Laboratories of Clinical Microbiology and Immunology, Rockefeller University, New York, New York. 3: BioVeris Corporation, Gaithersburg. 4: Microbial Pathogenesis and Immunology, Rockefeller University, New York, New York. 5: Department of Internal Medicine, Hospital Infantil De Mexico. 6: National Center for the Health of Infants and Adolescents, Secretary of Health, Mexico City, Mexico. 7: Division of Bacterial, Parasitic and Allergenic Products, Laboratory of Bacterial Polysaccharides, Food and Drug Administration, Rockville, Maryland.; Source Info: 1/1/2006, Vol. 193 Issue 1, p129; Subject Term: STREPTOCOCCUS; Subject Term: IMMUNOGLOBULINS; Subject Term: SERUM; Subject Term: MORTALITY; Subject Term: PROTEINS; Subject Term: DEMOGRAPHY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106344613
T1 - Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature.
AU - Epstein SL
Y1 - 2006/01//1/1/2006
N1 - Accession Number: 106344613. Language: English. Entry Date: 20061006. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Kilbourne ED. Influenza immunity: new insights from old studies. (J INFECT DIS) 1/1/2006; 193 (1): 7-8. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Center for Biologics Evaluation and Research, Food and Drug. NLM UID: 0413675.
KW - Disease Outbreaks
KW - Disease Susceptibility
KW - Influenza -- Immunology
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Antigen-Antibody Reactions
KW - Archives
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Disease Surveillance
KW - Fisher's Exact Test
KW - Funding Source
KW - Infant
KW - Infant, Newborn
KW - Influenza Vaccine
KW - Influenza -- Prevention and Control
KW - Influenza -- Transmission
KW - Middle Age
KW - Ohio
KW - Record Review
KW - Time Factors
KW - Human
SP - 49
EP - 53
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 193
IS - 1
PB - Oxford University Press / USA
AB - During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated. Copyright © 2006 Infectious Diseases Society of America
SN - 0022-1899
AD - Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. epsteins@cber.fda.gov
U2 - PMID: 16323131.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106448293
T1 - Bridging the resource gap between underserved communities and HIV/AIDS care: the challenges and the commitments.
AU - Hopson DP
Y1 - 2006///Winter2006
N1 - Accession Number: 106448293. Language: English. Entry Date: 20060602. Revision Date: 20150820. Publication Type: Journal Article; anecdote. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 9509701.
KW - Acquired Immunodeficiency Syndrome -- Therapy
KW - Financing, Government
KW - Health Services Accessibility
KW - HIV Infections -- Therapy
KW - Medically Underserved
KW - Acquired Immunodeficiency Syndrome -- Epidemiology
KW - Congresses and Conferences
KW - Cultural Competence
KW - Ethnic Groups
KW - Health Services Needs and Demand
KW - Poverty
KW - Primary Health Care
KW - United States
SP - 36
EP - 40
JO - Journal of Multicultural Nursing & Health (JMCNH)
JF - Journal of Multicultural Nursing & Health (JMCNH)
JA - J MULTICULT NURS HEALTH
VL - 12
IS - 1
CY - Houston, Texas
PB - Riley Publications
AB - OBJECTIVE(S): The Ryan White Comprehensive AIDS Resources Emergency (CARE) Act funds outpatient HIV/AIDS care for underserved individuals living in the United States. It is the largest HIV/AIDS-specific care program in the world. Representatives of organizations funded through the CARE Act met in Washington in August 2004 to address issues facing the HIV/AIDS care community and to learn more about effective care interventions. METHOD(S): At the opening plenary of the conference, Dr. Deborah Parham Hopson, Associate Administrator for AIDS at the Health Resources and Services Administration (HRSA), the agency that administers the CARE Act, discussed the challenges facing the CARE Act community. RESULT(S): Challenges include the growing HIV/AIDS prevalence, especially among minority and underserved communities; increasing demand for CARE Act funded services; health care cost inflation; and the hundreds of thousands of people living with HIV/AIDS who are still not in care. CONCLUSION(S): After defining the challenges, Dr. Parham Hopson identified key principles for commitment to reducing the unequal burden of HIV/AIDS for underserved communities in the United States in the future.
SN - 1526-8233
AD - Associate Administrator, HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106400181
T1 - AHRQ commentary. Quality tools to improve care and prevent errors.
AU - Nix MP
AU - Coopey M
AU - Clancy CM
Y1 - 2006/01//Jan-Mar2006
N1 - Accession Number: 106400181. Language: English. Entry Date: 20060224. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Health Care Errors -- Prevention and Control
KW - Quality Improvement
KW - Clinical Assessment Tools
KW - Documentation
KW - Information Resources
KW - Practice Guidelines
KW - United States Agency for Healthcare Research and Quality
KW - World Wide Web
SP - 1
EP - 4
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 21
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Room 6361, Rockville, MD 20850; mnix@ahrq.gov
U2 - PMID: 16340679.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Coffey, Christopher C.
AU - Lawrence, Robert B.
AU - Ziqing Zhuang
AU - Duling, Matthew G.
AU - Campbell, Donald L.
T1 - Errors Associated with Three Methods of Assessing Respirator Fit.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/01//
VL - 3
IS - 1
M3 - Article
SP - 44
EP - 52
SN - 15459624
AB - Three fit test methods (Bitrex, saccharin, and TSI PortaCount Plus with the N95-Companion) were evaluated for their ability to identify wearers of respirators that do not provide adequate protection during a simulated workplace test. Thirty models of NIOSH-certified N95 half-facepiece respirators (15 filtering-facepiece models and 15 elastomeric models) were tested by a panel of 25 subjects using each of the three fit testing methods. Fit testing results were compared to 5th percentiles of simulated workplace protection factors. Alpha errors (the chance of failing a fit test in error) for all 30 respirators were 71% for the Bitrex method, 68% for the saccharin method, and 40% for the Companion method. Beta errors (the chance of passing a fit test in error) for all 30 respirator models combined were 8% for the Bitrex method, 8% for the saccharin method, and 9% for the Companion method. The three fit test methods had different error rates when assessed with filtering facepieces and when assessed with elastomeric respirators. For example, beta errors for the three fit test methods assessed with the 15 filtering facepiece respirators were ≤5% but ranged from 14% to 21% when assessed with the 15 elastomeric respirators. To predict what happens in a realistic fit testing program, the data were also used to estimate the alpha and beta errors for a simulated respiratory protection program in which a wearer is given up to three trials with one respirator model to pass a fit test before moving onto another model. A subject passing with any of the three methods was considered to have passed the fit test program. The alpha and beta errors for the fit testing in this simulated respiratory protection program were 29% and 19%, respectively. Thus, it is estimated, under the conditions of the simulation, that roughly one in three respirator wearers receiving the expected reduction in exposure (with a particular model) will fail to pass (with that particular model), and that roughly one in five wearers receiving less reduction in exposure than expected will pass the fit testing program in error. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORS (Medical equipment)
KW - BREATHING apparatus
KW - WORK environment
KW - SACCHARIN
KW - ERRORS
KW - GAS masks
KW - ELASTOMERS
KW - FILTERS & filtration
KW - TESTING
KW - error rates
KW - fit test methods
KW - N95 half-facepiece respirators
KW - simulated respiratory protection program
N1 - Accession Number: 19031892; Coffey, Christopher C. 1 Lawrence, Robert B. 1 Ziqing Zhuang 2 Duling, Matthew G. 1 Campbell, Donald L. 2; Affiliation: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia 2: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania; Source Info: Jan2006, Vol. 3 Issue 1, p44; Subject Term: RESPIRATORS (Medical equipment); Subject Term: BREATHING apparatus; Subject Term: WORK environment; Subject Term: SACCHARIN; Subject Term: ERRORS; Subject Term: GAS masks; Subject Term: ELASTOMERS; Subject Term: FILTERS & filtration; Subject Term: TESTING; Author-Supplied Keyword: error rates; Author-Supplied Keyword: fit test methods; Author-Supplied Keyword: N95 half-facepiece respirators; Author-Supplied Keyword: simulated respiratory protection program; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; NAICS/Industry Codes: 325211 Plastics Material and Resin Manufacturing; NAICS/Industry Codes: 325212 Synthetic Rubber Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1080/15459620500455398
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106414494
T1 - Errors associated with three methods of assessing respirator fit.
AU - Coffey CC
AU - Lawrence RB
AU - Zhuang Z
AU - Duling MG
AU - Campbell DL
Y1 - 2006/01//
N1 - Accession Number: 106414494. Language: English. Entry Date: 20060324. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D1-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Evaluation
KW - Adult
KW - Education, Continuing (Credit)
KW - Female
KW - Male
KW - Middle Age
KW - Simulations
KW - Human
SP - 44
EP - 52
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Three fit test methods (Bitrex, saccharin, and TSI PortaCount Plus with the N95-Companion) were evaluated for their ability to identify wearers of respirators that do not provide adequate protection during a simulated workplace test. Thirty models of NIOSH-certified N95 half-facepiece respirators (15 filtering-facepiece models and 15 elastomeric models) were tested by a panel of 25 subjects using each of the three fit testing methods. Fit testing results were compared to 5th percentiles of simulated workplace protection factors. Alpha errors (the chance of failing a fit test in error) for all 30 respirators were 71% for the Bitrex method, 68% for the saccharin method, and 40% for the Companion method. Beta errors (the chance of passing a fit test in error) for all 30 respirator models combined were 8% for the Bitrex method, 8% for the saccharin method, and 9% for the Companion method. The three fit test methods had different error rates when assessed with filtering facepieces and when assessed with elastomeric respirators. For example, beta errors for the three fit test methods assessed with the 15 filtering facepiece respirators were < or = 5% but ranged from 14% to 21% when assessed with the 15 elastomeric respirators. To predict what happens in a realistic fit testing program, the data were also used to estimate the alpha and beta errors for a simulated respiratory protection program in which a wearer is given up to three trials with one respirator model to pass a fit test before moving onto another model. A subject passing with any of the three methods was considered to have passed the fit test program. The alpha and beta errors for the fit testing in this simulated respiratory protection program were 29% and 19%, respectively. Thus, it is estimated, under the conditions of the simulation, that roughly one in three respirator wearers receiving the expected reduction in exposure (with a particular model) will fail to pass (with that particular model), and that roughly one in five wearers receiving less reduction in exposure than expected will pass the fit testing program in error.
SN - 1545-9624
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505; ccoffey@cdc.gov
U2 - PMID: 16485349.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kalantzi, L.
AU - Reppas, C.
AU - Dressman, J.B.
AU - Amidon, G.L.
AU - Junginger, H.E.
AU - Midha, K.K.
AU - Shah, V.P.
AU - Stavchansky, S.A.
AU - Barends, Dirk M.
T1 - Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol).
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/01//
VL - 95
IS - 1
M3 - Article
SP - 4
EP - 14
SN - 00223549
AB - Literature data are reviewed on the properties of acetaminophen (paracetamol) related to the biopharmaceutics classification system (BCS). According to the current BCS criteria, acetaminophen is BCS Class III compound. Differences in composition seldom, if ever, have an effect on the extent of absorption. However, some studies show differences in rate of absorption between brands and formulations. In particular, sodium bicarbonate, present in some drug products, was reported to give an increase in the rate of absorption, probably caused by an effect on gastric emptying. In view of Marketing Authorizations (MAs) given in a number of countries to acetaminophen drug products with rapid onset of action, it is concluded that differences in rate of absorption were considered therapeutically not relevant by the Health Authorities. Moreover, in view of its therapeutic use, its wide therapeutic index and its uncomplicated pharmacokinetic properties, in vitro dissolution data collected according to the relevant Guidances can be safely used for declaring bioequivalence (BE) of two acetaminophen formulations. Therefore, accepting a biowaiver for immediate release (IR) acetaminophen solid oral drug products is considered scientifically justified, if the test product contains only those excipients reported in this paper in their usual amounts and the test product is rapidly dissolving, as well as the test product fulfils the criterion of similarity of dissolution profiles to the reference product. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95:4–14, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ABSORPTION (Physiology)
KW - BIOPHARMACEUTICS
KW - PHARMACOLOGY
KW - ACETAMINOPHEN
KW - ANALGESICS
KW - PERMEABILITY
KW - SOLUBILITY
KW - absorption
KW - acetaminophen
KW - Biopharmaceutics Classification System (BCS)
KW - bsorption
KW - paracetamol
KW - permeability
KW - solubility
N1 - Accession Number: 22171102; Kalantzi, L. 1 Reppas, C. 1 Dressman, J.B. 2 Amidon, G.L. 3 Junginger, H.E. 4 Midha, K.K. 5 Shah, V.P. 6 Stavchansky, S.A. 7 Barends, Dirk M. 8; Email Address: dirk.barends@rivm.nl; Affiliation: 1: School of Pharmacy, National & Kapodistrian University of Athens, Athens, Greece 2: JW Goethe University of Frankfurt, Frankfurt, Germany 3: College of Pharmacy, University of Michigan, Ann Arbor, Michigan 4: Leiden/Amsterdam Center for Drug Research, Leiden University, Division of Pharmaceutical Technology, Leiden, The Netherlands 5: University of Saskatchewan, Saskatoon, Saskatchewan, Canada 6: Center of Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 7: Pharmaceuticals Division, College of Pharmacy, University of Texas at Austin, Austin, Texas 8: RIVM, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Source Info: Jan2006, Vol. 95 Issue 1, p4; Subject Term: ABSORPTION (Physiology); Subject Term: BIOPHARMACEUTICS; Subject Term: PHARMACOLOGY; Subject Term: ACETAMINOPHEN; Subject Term: ANALGESICS; Subject Term: PERMEABILITY; Subject Term: SOLUBILITY; Author-Supplied Keyword: absorption; Author-Supplied Keyword: acetaminophen; Author-Supplied Keyword: Biopharmaceutics Classification System (BCS); Author-Supplied Keyword: bsorption; Author-Supplied Keyword: paracetamol; Author-Supplied Keyword: permeability; Author-Supplied Keyword: solubility; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1002/jps.20477
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106406784
T1 - Hurricane Isabel-related mortality -- Virginia, 2003.
AU - Jani AA
AU - Fierro M
AU - Kiser S
AU - Ayala-Simms V
AU - Darby DH
AU - Juenker S
AU - Storey R
AU - Reynolds C
AU - Marr J
AU - Miller G
Y1 - 2006/01//Jan/Feb2006
N1 - Accession Number: 106406784. Language: English. Entry Date: 20060310. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Mortality -- Epidemiology -- Virginia
KW - Mortality -- Risk Factors -- Virginia
KW - Natural Disasters -- Adverse Effects -- Virginia
KW - Public Health
KW - Risk Management
KW - Accidents, Traffic
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Alcohol Abuse
KW - Cause of Death -- Classification
KW - Child
KW - Descriptive Research
KW - Descriptive Statistics
KW - Drowning
KW - Environmental Exposure
KW - Epidemiological Research
KW - Female
KW - Geographic Factors
KW - Head Injuries
KW - Male
KW - Maps
KW - Medical Records
KW - Middle Age
KW - Record Review
KW - Risk Factors
KW - Stress -- Mortality
KW - Virginia
KW - Vital Statistics
KW - Wounds and Injuries -- Prevention and Control
KW - Human
SP - 97
EP - 102
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 12
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Hurricane Isabel had a massive negative environmental, public health, and economic impact; Virginia bore the highest death toll (32) among nine states affected by this storm. A descriptive mortality analysis was conducted to identify modifiable risk factors and corresponding injury prevention measures that might mitigate future natural disaster-related morbidity and mortality in Virginia. METHODS: Information for the decedents, including demographic data, health status, and injury circumstances, was collected from the records of the Virginia Office of the Chief Medical Examiner and Office of Vital Records/Health Statistics. Criteria from the National Hurricane Center were used to classify deaths as direct or indirect. Storm assessments and emergency-response reports were also reviewed. RESULTS: A total of 32 deaths associated with Hurricane Isabel occurred in several densely populated localities in southeastern and central Virginia. The median age of decedents was 48 years (range: 7-85 years). A disproportionately higher mortality (21 [66%] of 32) occurred among persons older than 45 years (Virginia 2000 Census data). Twelve deaths were directly caused by environmental factors related to the storm (eg, seven drowning deaths and five traumatic head injuries from falling trees). Twenty deaths were indirectly associated with the storm and its effects: six fatal motor vehicle crashes, five related to clean-up operations, seven associated with power outages, and two stress-related (ie, myocardial infarction and suicide). The presence of alcohol or drugs was observed in 9 (28%) of 32 deaths. CONCLUSIONS: Classifying deaths as direct or indirect facilitates better target interventions on the basis of the identification of modifiable risk factors underlying hurricane-associated fatal injuries. Public education messages that reinforce avoidance of use of alcohol and drugs during natural disaster situations might reduce risk for injury.
SN - 1078-4659
AD - US Public Health Service, Coordinating Office for Global Health, Centers for Disease Control and Prevention, Atlanta, GA; ajani@cdc.gov
U2 - PMID: 16340521.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Healthy Children: Putting Prevention First
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/01//
VL - 106
IS - 1
M3 - Editorial
SP - 17
EP - 17
SN - 00028223
N1 - Accession Number: 19591293; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Jan2006, Vol. 106 Issue 1, p17; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2005.11.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106434845
T1 - From the Surgeon General. Healthy children: putting prevention first.
AU - Carmona RH
Y1 - 2006/01//
N1 - Accession Number: 106434845. Language: English. Entry Date: 20060505. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Child Health
KW - Child Nutrition
KW - Health Promotion
KW - Nutrition Education -- In Infancy and Childhood
KW - Child
KW - Nutrition Policy
KW - Schools
SP - 17
EP - 17
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
U2 - PMID: 16390658.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - May, Joan C.
AU - Del Grosso, A.
AU - Etz, Nora
AU - Wheeler, R.
AU - Rey, L.
T1 - Thermogravimetry and vapor pressure moisture.
JO - Journal of Thermal Analysis & Calorimetry
JF - Journal of Thermal Analysis & Calorimetry
Y1 - 2006/01//
VL - 83
IS - 1
M3 - Article
SP - 31
EP - 33
PB - Springer Science & Business Media B.V.
SN - 13886150
AB - Thermogravimetry (TG), thermogravimetry/mass spectrometry (TG/MS), and loss-on-drying methodology are used to provide residual moisture results for freeze-dried biological products regulated by the US Food and Drug Administration. Residual moisture specifications must be met in order to ensure freeze-dried biological product potency and stability throughout the licensed product's shelf life. TG, TG/MS, loss-on-drying and vapor pressure moisture measurements are compared for a BCG Vaccine. Comparisons are made between residual moisture data for the freeze-dried cake and vapor pressure moisture determinations in the space above the freeze-dried cake in the final container. Vapor pressure moisture precision data is presented for α-interferon and BCG vaccine. Impact of residual moisture and vapor pressure moisture upon product stability is presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Thermal Analysis & Calorimetry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THERMOGRAVIMETRY
KW - THERMAL analysis
KW - VAPOR pressure
KW - SATURATION vapor pressure
KW - MASS spectrometry
KW - FREEZE-dried foods
KW - BCG vaccine
KW - lyophilization
KW - residual moisture
KW - thermogravimetry
N1 - Accession Number: 20004907; May, Joan C. 1; Email Address: may@cber.fda.gov Del Grosso, A. 1 Etz, Nora 1 Wheeler, R. 1 Rey, L. 2; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD, 20852 USA 2: Conseiller Scientifique, Chemin de Verdonnet 2, CH-1010 Lausanne, Switzerland; Source Info: Jan2006, Vol. 83 Issue 1, p31; Subject Term: THERMOGRAVIMETRY; Subject Term: THERMAL analysis; Subject Term: VAPOR pressure; Subject Term: SATURATION vapor pressure; Subject Term: MASS spectrometry; Subject Term: FREEZE-dried foods; Author-Supplied Keyword: BCG vaccine; Author-Supplied Keyword: lyophilization; Author-Supplied Keyword: residual moisture; Author-Supplied Keyword: thermogravimetry; Number of Pages: 3p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s10973-005-7052-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luebke, Robert W.
AU - Chen, David H.
AU - Dietert, Rodney
AU - Yung Yang
AU - King, Marquea
AU - Luster, Michael I.
T1 - The Comparative Immunotoxicity of Five Selected Compounds Following Developmental or Adult Exposure.
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2006/01//Jan/Feb2006
VL - 9
IS - 1
M3 - Article
SP - 1
EP - 26
SN - 10937404
AB - It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younger ages. Although not established absolutely, it is generally believed that development constitutes a period of increased immune system susceptibility to xenobiotics, since adverse effects may occur at lower doses and/or immunomodulation may be more persistent, thus increasing the relative risk of xenobiotic exposure to the immunologically immature organism. To address this issue, a brief overview of immune maturation in humans is provided to demonstrate that functional immaturity alone predisposes the young to infection. Age-dependent differences in the immunotoxic effects of five diverse compounds, diethylstilbestrol (DES), diazepam (DZP), lead (Pb), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and tributyltin oxide (TBTO), which have undergone adult and developmental immunotoxicity testing in rodents, are then reviewed, as are human data when available. For all five chemicals, the developing immune system was found to be at greater risk than that of the adult, either because lower doses produced immunotoxicity, adverse effects were more persistent, or both. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE system
KW - IMMUNOLOGY
KW - IMMUNE response -- Regulation
KW - BIOLOGICAL response modifiers
KW - ANTIGEN-antibody reactions
KW - EXPERIMENTAL immunology
KW - IMMUNE response
KW - BLOOD platelets -- Immunology
KW - BIOCHEMISTRY
KW - ANALYTICAL biochemistry
N1 - Accession Number: 19277492; Luebke, Robert W. 1; Email Address: luebke.robert@epi.gov Chen, David H. 2 Dietert, Rodney 3 Yung Yang 4 King, Marquea 5 Luster, Michael I. 6; Affiliation: 1: Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA 2: Office of Children's Health Protection, U.S. Environmental Protection Agency, Washington, DC, USA 3: Department of Microbiology and Immunology, Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, New York, USA 4: Office of Pesticides Program, U.S. Environmental Protection Agency, Washington, DC, USA 5: Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, DC, USA 6: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Source Info: Jan/Feb2006, Vol. 9 Issue 1, p1; Subject Term: IMMUNE system; Subject Term: IMMUNOLOGY; Subject Term: IMMUNE response -- Regulation; Subject Term: BIOLOGICAL response modifiers; Subject Term: ANTIGEN-antibody reactions; Subject Term: EXPERIMENTAL immunology; Subject Term: IMMUNE response; Subject Term: BLOOD platelets -- Immunology; Subject Term: BIOCHEMISTRY; Subject Term: ANALYTICAL biochemistry; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 26p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/15287390500194326
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Vallyathan, Val
T1 - Respiratory Burst: Role in Signal Transduction in Alveolar Macrophages.
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2006/01//Jan/Feb2006
VL - 9
IS - 1
M3 - Article
SP - 27
EP - 39
SN - 10937404
AB - Alveolar macrophages play an important role in defense against airborne pathogens and particles. These macrophages respond through both the adaptive and acquired immune responses, and through the activation of a multitude of signaling pathways. One major macrophage defense mechanism is respiratory burst, the production of reactive oxygen species (ROS). While the ROS produced may act directly in pathogen killing, they may also be involved as secondary signaling messengers. This review focuses on the activation of four main signaling pathways following the production of reactive oxygen species. These pathways include the nuclear factor kappa beta (NFkB), activating protein-1 (AP-1), mitogen-activating protein kinase (MAPK), and phosphotidyl inositol-3 kinase (PI3K) pathways. This review also briefly examines the role of ROS in DNA damage, in particular looking at the base excision repair pathway (BER), the main pathway involved in repair of oxidative DNA damage. This review highlights many of the studies in the field of ROS, signal transduction, and DNA damage; however, work still remains to further elucidate the role of ROS in disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - KILLER cells
KW - PATHOGENIC microorganisms
KW - IMMUNE response
KW - IMMUNOLOGY
KW - ANTIGEN-antibody reactions
KW - IMMUNE recognition
KW - IMMUNOLOGICAL tolerance
KW - INFLAMMATION -- Immunological aspects
KW - PROTEIN kinases
KW - MUTATION (Biology)
KW - GENETICS
KW - DNA damage
N1 - Accession Number: 19277491; Gwinn, Maureen R. 1 Vallyathan, Val 1; Email Address: vav1@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Jan/Feb2006, Vol. 9 Issue 1, p27; Subject Term: MACROPHAGES; Subject Term: KILLER cells; Subject Term: PATHOGENIC microorganisms; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: ANTIGEN-antibody reactions; Subject Term: IMMUNE recognition; Subject Term: IMMUNOLOGICAL tolerance; Subject Term: INFLAMMATION -- Immunological aspects; Subject Term: PROTEIN kinases; Subject Term: MUTATION (Biology); Subject Term: GENETICS; Subject Term: DNA damage; Number of Pages: 13p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1080/15287390500196081
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Caruso, Joseph A.
AU - Wuilloud, Rodolfo G.
AU - Altamirano, Jorgelina C.
AU - Harris, Wesley R.
T1 - Modeling and Separation–Detection Methods to Evaluate the Speciation of Metals for Toxicity Assessment.
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2006/01//Jan/Feb2006
VL - 9
IS - 1
M3 - Article
SP - 41
EP - 61
SN - 10937404
AB - There is an increasing appreciation for the importance of speciation in the assessment of metal toxicity. In this review, two approaches to speciation are discussed, with an emphasis on their application to biological samples. One approach is the direct separation and detection of metal species of toxicological interest. Various “hyphenated” techniques, consisting of a chromatographic system coupled to inductively coupled plasma–mass spectrometry (ICP-MS), are discussed. The chromatographic strategies employed for separation emphasize liquid chromatography (LC), but the increasing use of gas chromatography (GC) and capillary electrophoresis (CE) in speciation analysis is discussed. The second approach to speciation is the use of computer models to calculate the speciation of a metal ion within a complex mixture of ligands. This approach is applicable to systems in which the metal cation exchanges ligands rapidly, so that the sample represents an equilibrium mixture of metal complexes. These computational models are based on the equilibrium constants for the metal complexes and a series of mass balance equations and give the distribution of metal complexes in the original sample. This approach is illustrated using the speciation of Al(III) in serum as an example. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXINS
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - CAPILLARY liquid chromatography
KW - COUNTERCURRENT chromatography
KW - ANALYTICAL chemistry
KW - CAPILLARY electrophoresis
KW - PHASE partition
KW - GAS chromatography
N1 - Accession Number: 19277489; Caruso, Joseph A. 1 Wuilloud, Rodolfo G. 1 Altamirano, Jorgelina C. 2 Harris, Wesley R. 3; Email Address: wharris@umsl.edu.; Affiliation: 1: University of Cincinnati, Cincinnati, Ohio, USA 2: U.S. Food and Drug Administration, Cincinnati, Ohio, USA 3: University of Missouri-St. Louis, St. Louis, Missouri, USA; Source Info: Jan/Feb2006, Vol. 9 Issue 1, p41; Subject Term: TOXINS; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: CAPILLARY liquid chromatography; Subject Term: COUNTERCURRENT chromatography; Subject Term: ANALYTICAL chemistry; Subject Term: CAPILLARY electrophoresis; Subject Term: PHASE partition; Subject Term: GAS chromatography; Number of Pages: 21p; Illustrations: 3 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15287390500196172
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Butrapet, Siritorn
AU - Kinney, Richard M.
AU - Huang, Claire Y.-H.
T1 - Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK-53 virus by sequencing and quantitative TaqMAMA
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/01//
VL - 131
IS - 1
M3 - Article
SP - 1
EP - 9
SN - 01660934
AB - Abstract: The genetic stabilities of the three attenuation loci of the candidate dengue 2 (D2) PDK-53 vaccine virus were evaluated for the PDK-53 virus and PDK-53-vectored chimeric D2/1, D2/3, and D2/4 viruses following 10 sequential passages in Vero cells. Sequencing revealed that the dominant NS1–53-Asp and the NS3–250-Val attenuation loci were extremely stable, whereas reversion occurred at the 5′NCR-57-U locus in 10 of the 18 viral lineages tested. A more sensitive and quantitative assay, the TaqMan mismatch amplification mutation assay (TaqMAMA), was employed to more finely discriminate the level of reversion at the 5′NCR-57 locus. This rapid genetic assay permitted detection of ≤1% reversion of 5′NCR-57 U-to-C in viral populations. By TaqMAMA, various levels of reversion at 5′NCR-57 were detected in all 18 of the PDK-53-based viral lineages tested at Vero passage 10, but only 3 lineages had reversion levels >80% in the viral population. Chimeric viruses based on the PDK-53-V (all three mutations present) genetic background were more stable than those developed in the PDK-53-E (5′NCR and NS1 mutations present) background. The TaqMAMA can be applied in quality control analyses to ensure that attenuated vaccine seeds contain undetectable or minimal levels of reversion at a given attenuation locus. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE
KW - PREVENTIVE medicine
KW - VACCINATION
KW - MICROORGANISMS
N1 - Accession Number: 19182696; Butrapet, Siritorn 1 Kinney, Richard M. 1 Huang, Claire Y.-H.; Email Address: CHuang1@cdc.gov; Affiliation: 1: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522, USA; Source Info: Jan2006, Vol. 131 Issue 1, p1; Subject Term: DENGUE; Subject Term: PREVENTIVE medicine; Subject Term: VACCINATION; Subject Term: MICROORGANISMS; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jviromet.2005.06.019
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
AU - Ray, Tapas K.
AU - Segerson, Kathleen
AD - National Institute of Occupational Safety and Health, Centers for Disease Control, Bethesda, MD
AD - U CT
A2 - Coglianese, Cary
A2 - Nash, Jennifer
T1 - Clean Charles 2005 Initiative: Why the 'Success'?
T2 - Leveraging the Private Sector: Management-Based Strategies for Improving Environmental Performance
PB - Washington, D.C.:
PB - Resources for the Future
Y1 - 2006///
SP - 201
EP - 227
N1 - Accession Number: 0944406; Reviewed Book ISBN: 1-891853-95-3 (cloth); 1-891853-96-1 (pbk); ; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200712
KW - State and Local Government: Other Expenditure Categories H76
KW - Renewable Resources and Conservation: Fishery; Aquaculture Q22
KW - Renewable Resources and Conservation: Water Q25
KW - Renewable Resources and Conservation: Government Policy Q28
KW - Air Pollution; Water Pollution; Noise; Hazardous Waste; Solid Waste; Recycling Q53
KW - Environmental Economics: Government Policy Q58
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Kachur, S. Patrick
AU - Black, Carolyn
AU - Abdulla, Salim
AU - Goodman, Catherine
T1 - Putting the genie back in the bottle? Availability and presentation of oral artemisinin compounds at retail pharmacies in urban Dar-es-Salaam.
JO - Malaria Journal
JF - Malaria Journal
Y1 - 2006/01//
VL - 5
M3 - Article
SP - 25
EP - 8
PB - BioMed Central
SN - 14752875
AB - Background: Recently global health advocates have called for the introduction of artemisinincontaining antimalarial combination therapies to help curb the impact of drug-resistant malaria in Africa. Retail trade in artemisinin monotherapies could undermine efforts to restrict this class of medicines to more theoretically sound combination treatments. Methods: This paper describes a systematic search for artemisinin-containing products at a random sample of licensed pharmacies in Dar-es-Salaam, Tanzania in July 2005. Results: Nineteen different artemisinin-containing oral pharmaceutical products, including one coformulated product, one co-packaged product, and 17 monotherapies were identified. All but one of the products were legally registered and samples of each product were obtained without a prescription. Packaging and labeling of the products seldom included local language or illustrated instructions for low-literate clients. Packaging and inserts compared reasonably well with standards recommended by the national regulatory authority with some important exceptions. Dosing instructions were inconsistent, and most recommended inadequate doses based on international standards. None of the monotherapy products mentioned potential benefits of combining the treatment with another antimalarial drug. Conclusion: The findings confirm the widespread availability of artemisinin monotherapies that led the World Health Organization to call for the voluntary withdrawal of these drugs in malariaendemic countries. As the global public health community gathers resources to deploy artemisinincontaining combination therapies in Africa, planners should be mindful that these drugs will coexist with artemisinin monotherapies in an already well-established market place. In particular, regulatory authorities should be incorporated urgently into the process of planning for rational deployment of artemisinin-containing antimalarial combination therapies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Malaria Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTEMISININ
KW - DRUGSTORES
KW - DRUG resistance
KW - RETAIL industry
KW - DAR es Salaam (Tanzania)
KW - TANZANIA
N1 - Accession Number: 30094760; Kachur, S. Patrick 1,2; Email Address: skachur@cdc.gov Black, Carolyn 1,3; Email Address: black1@umbc.edu Abdulla, Salim 1; Email Address: salim.abdulla@gmail.com Goodman, Catherine 4; Email Address: catherine.goodman@lshtm.ac.uk; Affiliation: 1: Ifakara Health Research and Development Centre, Ifakara, P.O. Box 78373, Dar-es-Salaam, Tanzania 2: United States Public Health Service Commissioned Corps and Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3: University of Maryland Baltimore County, Baltimore, Maryland, USA 4: Health Economics and Financing Programme, Health Policy Unit, London School of Hygiene and Tropical Medicine, London, UK; Source Info: 2006, Vol. 5, p25; Subject Term: ARTEMISININ; Subject Term: DRUGSTORES; Subject Term: DRUG resistance; Subject Term: RETAIL industry; Subject Term: DAR es Salaam (Tanzania); Subject Term: TANZANIA; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 452999 All other miscellaneous general merchandise stores; NAICS/Industry Codes: 453998 All Other Miscellaneous Store Retailers (except Tobacco Stores); NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1186/1475-2875-5-25
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=30094760&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hetzel, Manuel W.
AU - Msechu, June J.
AU - Goodman, Catherine
AU - Lengeler, Christian
AU - Obrist, Brigit
AU - Kachur, S. Patrick
AU - Makemba, Ahmed
AU - Nathan, Rose
AU - Schulze, Alexander
AU - Mshinda, Hassan
T1 - Decreased availability of antimalarials in the private sector following the policy change from chloroquine to sulphadoxine-pyrimethamine in the Kilombero Valley, Tanzania.
JO - Malaria Journal
JF - Malaria Journal
Y1 - 2006/01//
VL - 5
M3 - Article
SP - 109
EP - 12
PB - BioMed Central
SN - 14752875
AB - Background: Malaria control strategies emphasize the need for prompt and effective treatment of malaria episodes. To increase treatment efficacy, Tanzania changed its first-line treatment from chloroquine to sulphadoxine-pyrimethamine (SP) in 2001. The effect of this policy change on the availability of antimalarials was studied in rural south-eastern Tanzania. Methods: In 2001 and 2004, the study area was searched for commercial outlets selling drugs and their stocks were recorded. Household information was obtained from the local Demographic Surveillance System. Results: From 2001 to 2004, the number of general shops stocking drugs increased by 15% and the number of drug stores nearly doubled. However, the proportion of general shops stocking antimalarials dropped markedly, resulting in an almost 50% decrease of antimalarial selling outlets. This led to more households being located farther from a treatment source. In 2004, five out of 25 studied villages with a total population of 13,506 (18%) had neither a health facility, nor a shop as source of malaria treatment.Conclusion: While the change to SP resulted in a higher treatment efficacy, it also led to a decreased antimalarial availability in the study area. Although there was no apparent impact on overall antimalarial use, the decline in access may have disproportionately affected the poorest and most remote groups. In view of the imminent policy change to artemisinin-based combination therapy these issues need to be addressed urgently if the benefits of this new class of antimalarials are to be extended to the whole population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Malaria Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA
KW - ANTIMALARIALS
KW - CHLOROQUINE
KW - ARTEMISININ
KW - TREATMENT
KW - TANZANIA
N1 - Accession Number: 30094735; Hetzel, Manuel W. 1,2; Email Address: manuel.hetzel@unibas.ch Msechu, June J. 2; Email Address: jmsechu@udsm.ac.tz Goodman, Catherine 3; Email Address: Catherine.Goodman@lshtm.ac.uk Lengeler, Christian 1; Email Address: christian.lengeler@unibas.ch Obrist, Brigit 1; Email Address: brigit.obrist@unibas.ch Kachur, S. Patrick 2,4; Email Address: skachur@cdc.gov Makemba, Ahmed 2; Email Address: makemba_am@yahoo.co.uk Nathan, Rose 2; Email Address: rosenathan2001@yahoo.co.uk Schulze, Alexander 5; Email Address: alexander.schulze@novartis.com Mshinda, Hassan 2; Email Address: hmshinda@ihrdc.or.tz; Affiliation: 1: Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland 2: Ifakara Health Research and Development Centre, Ifakara, Tanzania 3: Health Policy Unit, London School of Hygiene and Tropical Medicine, London, UK 4: U. S. Public Health Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 5: Novartis Foundation for Sustainable Development, Basel, Switzerland; Source Info: 2006, Vol. 5, p109; Subject Term: MALARIA; Subject Term: ANTIMALARIALS; Subject Term: CHLOROQUINE; Subject Term: ARTEMISININ; Subject Term: TREATMENT; Subject Term: TANZANIA; Number of Pages: 12p; Illustrations: 4 Charts, 3 Graphs, 2 Maps; Document Type: Article
L3 - 10.1186/1475-2875-5-109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=30094735&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dheenadhayalan, Veerabadran
AU - Delogu, Giovanni
AU - Brennan, Michael J.
T1 - Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival.
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/01//
VL - 8
IS - 1
M3 - Article
SP - 262
EP - 272
SN - 12864579
AB - Abstract: Research on mycobacteria-specific PE_PGRS genes indicates that they code for cell surface proteins that may influence virulence and the infection of host cells by mycobacteria. In the studies presented here, we have expressed the PE_PGRS 33 gene in a non-pathogenic fast-growing Mycobacterium smegmatis strain and demonstrated that it survives better in macrophage cultures, in vitro as well as in mice after intraperitoneal administration, than the parental strain containing the vector only or a strain expressing only the PE domain of PE_PGRS 33. In macrophages, enhanced colonization by the M. smegmatis expressing PE_PGRS 33 was associated with macrophage aggregation and clearance of macrophage monolayers, visible cell necrosis and significantly greater levels of TNF (TNF-α) in the cultures compared with controls. The presence of macrophage cell necrosis was confirmed by measurement of significantly greater levels of lactate dehydrogenase and nucleosomes in the supernatants of the macrophage cultures infected with M. smegmatis expressing PE_PGRS 33. Antibodies directed against TNF partially reduced cytolysis, suggesting that this cytokine is critical but not sufficient for the observed macrophage necrosis and enhanced mycobacterial survival. These results extend earlier observations, which suggested that PE_PGRS proteins may have a role in the pathogenesis of mycobacterial disease and that there may be a specific role for these proteins in influencing host cell responses to infection. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacterial diseases
KW - Cytokines
KW - Tumor necrosis factor
KW - Lung diseases
KW - bone marrow macrophages ( BMMO )
KW - colony forming unit ( CFU )
KW - lactate dehydrogenase ( LDH )
KW - multiplicity of infection ( MOI )
KW - Mycobacterium smegmatis
KW - PE_PGRS genes
KW - phosphate buffered saline ( PBS )
KW - Tuberculosis
KW - tumor necrosis factor ( TNF )
N1 - Accession Number: 19598732; Dheenadhayalan, Veerabadran 1; Email Address: Dheenadhayalan@cber.fda.gov; Delogu, Giovanni 2; Email Address: gdelogu@rm.unicatt.it; Brennan, Michael J. 1; Email Address: Brennan@cber.fda.gov; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA; 2: Institute of Microbiology, Catholic University of the Sacred Heart, Largo F. Vito, 00168 Rome, Italy; Issue Info: Jan2006, Vol. 8 Issue 1, p262; Subject Term: Mycobacterial diseases; Subject Term: Cytokines; Subject Term: Tumor necrosis factor; Subject Term: Lung diseases; Author-Supplied Keyword: bone marrow macrophages ( BMMO ); Author-Supplied Keyword: colony forming unit ( CFU ); Author-Supplied Keyword: lactate dehydrogenase ( LDH ); Author-Supplied Keyword: multiplicity of infection ( MOI ); Author-Supplied Keyword: Mycobacterium smegmatis; Author-Supplied Keyword: PE_PGRS genes; Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: tumor necrosis factor ( TNF ); Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.micinf.2005.06.021
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Peixuan Zhu
AU - Boykins, Robert A.
AU - Chao-Ming Tsai
T1 - Genetic and functional analyses of the IgtH gene, a member of the ß-1,4-galactosyltransferase gene family in the genus Neisseria.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2006/01//
VL - 152
IS - 1
M3 - Article
SP - 123
EP - 134
SN - 13500872
AB - The article cites a study on the biological function of IgtH, a galactosyltransferase gene, in the genus Neisseria using mutagenesis as an approach. Researchers have analyzed the involvement of IgtH on the biosynthesis of lipooligosaccharide, a major virulence factor of the pathogenic Neisseria. In conclusion, this study revealed that biological function of this gene encodes a β1,4-galactosyltransferase.
KW - Microbiology
KW - Galactosyltransferases
KW - Neisseria
KW - Transferases
KW - Neisseriaceae
KW - Mutagenesis
N1 - Accession Number: 19563590; Peixuan Zhu 1; Email Address: pzhu@creatvmicrotech.com; Boykins, Robert A. 1; Chao-Ming Tsai 1; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA; Issue Info: Jan2006, Vol. 152 Issue 1, p123; Thesaurus Term: Microbiology; Subject Term: Galactosyltransferases; Subject Term: Neisseria; Subject Term: Transferases; Subject Term: Neisseriaceae; Subject Term: Mutagenesis; Number of Pages: 12p; Illustrations: 4 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1099/mic.0.28327-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19563590&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2006-11904-010
AN - 2006-11904-010
AU - Campise, Rick L.
AU - Geller, Schuyler K.
AU - Campise, Mary E.
ED - Kennedy, Carrie H.
ED - Zillmer, Eric A.
ED - Kennedy, Carrie H., (Ed)
ED - Zillmer, Eric A., (Ed)
T1 - Combat Stress.
T2 - Military psychology: Clinical and operational applications.
Y1 - 2006///
SP - 215
EP - 240
CY - New York, NY, US
PB - Guilford Press
SN - 1572307242
SN - 9781572307247
N1 - Accession Number: 2006-11904-010. Partial author list: First Author & Affiliation: Campise, Rick L.; United States Air Force, Air Force Deployment Behavioral Health, Air Force Medical Operations Agency, Office of the Surgeon General, Falls Church, VA, US. Release Date: 20061106. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1572307242, Hardcover; 9781572307247, Hardcover. Language: English. Major Descriptor: Combat Experience; Military Personnel; Posttraumatic Stress Disorder; Stress Reactions; War. Minor Descriptor: Fatigue. Classification: Military Psychology (3800); Neuroses & Anxiety Disorders (3215). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - The term 'combat stress' has undergone a variety of name changes over the course of time (Jones, 1995; U.S. Department of the Army, 1994a). During the American Civil War, combat stress was identified as nostalgia and homesickness. In World War I (WWI), this experience was referred to as shell shock, effort syndrome, war neurosis, gas hysteria, Da Costa's syndrome, irritable heart syndrome, and not-yet-diagnosed nervous. The terms psychoneurosis, effort syndrome, combat exhaustion, battle fatigue, and operational fatigue were used in World War II (WWII). During the Korean War, this package of symptoms was identified as battle fatigue and combat exhaustion. In the Vietnam War, the terms combat stress and posttraumatic stress syndrome were applied and posttraumatic stress disorder (PTSD) was used after the war. During the Gulf War (Operation Desert Storm), this symptom package became commonly identified as 'combat stress reaction.' At this time, some use the term 'combat operational stress' as well as 'combat operational stress reaction.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - combat stress reaction
KW - posttraumatic stress disorder
KW - combat exhaustion
KW - 2006
KW - Combat Experience
KW - Military Personnel
KW - Posttraumatic Stress Disorder
KW - Stress Reactions
KW - War
KW - Fatigue
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11904-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Verma, Mukesh
AU - Seminara, Daniela
AU - Arena, Fernando J.
AU - John, Christy
AU - Iwamoto, Kumiko
AU - Hartmuller, Virginia
T1 - Genetic and Epigenetic Biomarkers in Cancer.
JO - Molecular Diagnosis & Therapy
JF - Molecular Diagnosis & Therapy
Y1 - 2006/01//
VL - 10
IS - 1
M3 - Article
SP - 1
EP - 15
SN - 11771062
AB - Gene expression patterns change during the initiation, progression, and development of cancer, as a result of both genetic and epigenetic mechanisms. Genetic changes arise due to irreversible changes in the nucleotide sequence, whereas epigenetic changes occur due to changes in chromatin conformation, histone acetylation, and methylation of the CpG islands located primarily in the promoter region of a gene. Both genetic and epigenetic markers can potentially be utilized to identify different stages of tumor development. Several such markers exhibit high sensitivity and specificity for different tumor types and can be assayed in biofluids and other specimens collected by noninvasive technologies. In spite of the availability of large numbers of diagnostic markers, only a few have been clinically validated so far. The current status and the challenges in the field of genetic and epigenetic markers in cancer diagnosis, risk assessment, and disease stratification are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Diagnosis & Therapy is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - CANCER -- Diagnosis
KW - TUMOR markers
KW - NUCLEOTIDE sequence
KW - CHROMATIN
KW - ACETYLATION
KW - METHYLATION
KW - TUMORS
N1 - Accession Number: 23284441; Verma, Mukesh 1; Email Address: vermam@mail.nih.gov Seminara, Daniela 2 Arena, Fernando J. 2 John, Christy 3 Iwamoto, Kumiko 1 Hartmuller, Virginia 1; Affiliation: 1: Analytic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA 2: Clinical Epidemiology and Genetics Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA 3: Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2006, Vol. 10 Issue 1, p1; Subject Term: GENE expression; Subject Term: CANCER -- Diagnosis; Subject Term: TUMOR markers; Subject Term: NUCLEOTIDE sequence; Subject Term: CHROMATIN; Subject Term: ACETYLATION; Subject Term: METHYLATION; Subject Term: TUMORS; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chuan-ging Wu
AU - Budhu, Anuradha
AU - Sheng Chen
AU - Xiaoling Zhou
AU - Popescu, Nicholas C.
AU - Valerie, Kristoffer
AU - Xin Wei Wang
T1 - Effect of Hepatitis C Virus Core Protein on the Molecular Profiling of Human B Lymphocytes.
JO - Molecular Medicine
JF - Molecular Medicine
Y1 - 2006/01//Jan-Mar2006
VL - 12
IS - 1-3
M3 - Article
SP - 47
EP - 53
SN - 10761551
AB - Hepatitis C virus (HCV) core protein features many intriguing properties and plays a pivotal role in cellular immunity, cell growth, apoptosis, cell transformation, and eventually in tumor development. However, the role of B cells, the primary players in the humoral immune response, during HCV infection is largely unknown. To explore the molecular effects of HCV core on human B cells, we conducted gene expression profiling of serial RNA samples from B cells that were infected with adenovirus harboring full-length HCV core protein and β-galactosidase as a reference using a microarray platform containing 22,149 human oligo probes. The entire experiment was performed in duplicate in B lymphocytes that were isolated from two individual donors and incubated for up to 3 days after infection with adenovirus expressing HCV core protein to identify dynamic gene expression patterns. Differential expression of representative genes was validated by quantitative RT-PCR. We found that HCV core significantly inhibited B-lymphocyte apoptosis. We showed a dramatic downregulation of MHC class II molecules in B cells expressing HCV core, whereas the expression of immunoglobulin genes was not significantly altered. Moreover, genes associated with leukemia and B-lymphoma were consistently upregulated by HCV core. In contrast, downregulation of caspase-1 and caspase-4 was found to be associated with core's ability to prevent B-lymphocyte apoptosis. In summary, we have identified several clusters of genes that are differentially expressed in human B lymphocytes expressing HCV core, suggesting a potential impairment of antigen processing and presentation, which may provide more insights into HCV infection in B lymphocytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Medicine is the property of Feinstein Institute for Medical Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - VIRAL proteins
KW - CELLULAR immunity
KW - APOPTOSIS
KW - CELL transformation
KW - GENE expression
N1 - Accession Number: 22350540; Chuan-ging Wu 1; Email Address: xw3u@nih.gov Budhu, Anuradha 2 Sheng Chen 3 Xiaoling Zhou 4 Popescu, Nicholas C. 4 Valerie, Kristoffer 5 Xin Wei Wang 2; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA 3: Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA 4: Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA 5: Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA; Source Info: Jan-Mar2006, Vol. 12 Issue 1-3, p47; Subject Term: HEPATITIS C virus; Subject Term: VIRAL proteins; Subject Term: CELLULAR immunity; Subject Term: APOPTOSIS; Subject Term: CELL transformation; Subject Term: GENE expression; Number of Pages: 7p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.2119/2006-00020.Wu
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manickan, Elanchezhiyan
AU - Smith, Jeffrey S.
AU - Tian, Jie
AU - Eggerman, Thomas L.
AU - Lozier, Jay N.
AU - Muller, Jacqueline
AU - Byrnes, Andrew P.
T1 - Rapid Kupffer Cell Death after Intravenous Injection of Adenovirus Vectors.
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2006/01//
VL - 13
IS - 1
M3 - Article
SP - 108
EP - 117
SN - 15250016
AB - When adenovirus vectors are injected intravenously, they are quickly taken up by Kupffer cells in the liver. We report that this causes rapid necrosis of Kupffer cells in mice at doses of 1011 particles/kg or higher. By 10 min after intravenous vector injection, Kupffer cells were permeable to propidium iodide and trypan blue. This coincided with a sharp rise in serum lactate dehydrogenase. Ultrastructural examination showed degeneration of Kupffer cells, including complete disappearance of chromatin by 1 h. After an initial intravenous injection of vector, dead Kupffer cells were unable to take up a second dose of vector, and hepatic transgene expression from the second dose was augmented. Death of Kupffer cells did not affect serum levels of IL-6 or IL-12. There was no immediate change in the number of Kupffer cells in the liver, but a significant decline was found by 4 h after injection of vector. Interestingly, substantial numbers of vector-containing Kupffer cells were found in pulmonary capillaries, indicating that they had been swept out of the liver. Together these results show that an intravenous injection of adenovirus vector causes synchronous and surprisingly rapid Kupffer cell death.Molecular Therapy (2006) 13, 108–117; doi: 10.1016/j.ymthe.2005.08.007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KUPFFER cells
KW - CELL death
KW - ADENOVIRUS diseases
KW - GENETIC vectors
KW - BLOOD plasma
KW - INTRAVENOUS therapy
KW - DEHYDROGENASES
KW - LIVER cells
KW - adenoviridae
KW - electron microscopy
KW - gene therapy
KW - genetic vectors
KW - intravenous injections
KW - Kupffer cells
KW - liver
KW - lung
KW - necrosis
N1 - Accession Number: 25973109; Manickan, Elanchezhiyan 1 Smith, Jeffrey S. 1 Tian, Jie 1 Eggerman, Thomas L. 2 Lozier, Jay N. 3 Muller, Jacqueline 4 Byrnes, Andrew P. 1; Email Address: byrnesa@cber.fda.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Food and Drug Administration, Bethesda, MD 20892, USA 2: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA 3: Division of Hematology, Food and Drug Administration, Bethesda, MD 20892, USA 4: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jan2006, Vol. 13 Issue 1, p108; Subject Term: KUPFFER cells; Subject Term: CELL death; Subject Term: ADENOVIRUS diseases; Subject Term: GENETIC vectors; Subject Term: BLOOD plasma; Subject Term: INTRAVENOUS therapy; Subject Term: DEHYDROGENASES; Subject Term: LIVER cells; Author-Supplied Keyword: adenoviridae; Author-Supplied Keyword: electron microscopy; Author-Supplied Keyword: gene therapy; Author-Supplied Keyword: genetic vectors; Author-Supplied Keyword: intravenous injections; Author-Supplied Keyword: Kupffer cells; Author-Supplied Keyword: liver; Author-Supplied Keyword: lung; Author-Supplied Keyword: necrosis; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ymthe.2005.08.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parsons, Barbara L.
AU - Delongchamp, Robert R.
AU - Beland, Frederick A.
AU - Heflich, Robert H.
T1 - Levels of H-ras codon 61 CAA to AAA mutation: response to 4-ABP-treatment and Pms2-deficiency.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2006/01//
VL - 21
IS - 1
M3 - Article
SP - 29
EP - 34
PB - Oxford University Press / USA
SN - 02678357
AB - DNA mismatch repair (MMR) deficiencies result in increased frequencies of spontaneous mutation and tumor formation. In the present study, we tested the hypothesis that a chemically-induced mutational response would be greater in a mouse with an MMR-deficiency than in the MMR-proficient mouse models commonly used to assay for chemical carcinogenicity. To accomplish this, the induction of H-ras codon 61 CAA→AAA mutation was examined in Pms2 knockout mice (Pms2−/−, C57BL/6 background) and sibling wild-type mice (Pms2+/+). Groups of five or six neonatal male mice were treated with 0.3 µmol 4-aminobiphenyl (4-ABP) or the vehicle control, dimethylsulfoxide. Eight months after treatment, liver DNAs were isolated and analysed for levels of H-ras codon 61 CAA→AAA mutation using allele-specific competitive blocker-PCR. In Pms2-proficient and Pms2-deficient mice, 4-ABP treatment caused an increase in mutant fraction (MF) from 1.65 × 10−5 to 2.91 × 10−5 and from 3.40 × 10−5 to 4.70 × 10−5, respectively. Pooling data from 4-ABP-treated and control mice, the ∼2-fold increase in MF observed in Pms2-deficient as compared with Pms2-proficient mice was statistically significant (P = 0.0207) and consistent with what has been reported previously in terms of induction of G:C→T:A mutation in a Pms2-deficient background. Pooling data from both genotypes, the increase in H-ras MF in 4-ABP-treated mice, as compared with control mice, did not reach the 95% confidence level of statistical significance (P = 0.0606). The 4-ABP treatment caused a 1.76-fold and 1.38-fold increase in average H-ras MF in Pms2-proficient and Pms2-deficient mice, respectively. Furthermore, the levels of induced mutation in Pms2-proficient and Pms2-deficient mice were nearly identical (1.26 × 10−5 and 1.30 × 10−5, respectively). We conclude that Pms2-deficiency does not result in an amplification of the H-ras codon 61 CAA→AAA mutational response induced by 4-ABP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Genetic polymorphisms
KW - DNA repair
KW - Biliary tract
KW - Cancer -- Diagnosis
N1 - Accession Number: 19777186; Parsons, Barbara L. 1; Email Address: bparsons@nctr.fda.gov; Delongchamp, Robert R. 2; Beland, Frederick A. 3; Heflich, Robert H. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA; 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA; Issue Info: Jan2006, Vol. 21 Issue 1, p29; Thesaurus Term: Mutation (Biology); Subject Term: Genetic polymorphisms; Subject Term: DNA repair; Subject Term: Biliary tract; Subject Term: Cancer -- Diagnosis; Number of Pages: 6p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1093/mutage/gei066
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fichtner-Feigl, Stefan
AU - Strober, Warren
AU - Kawakami, Koji
AU - Puri, Raj K.
AU - Kitani, Atsushi
T1 - IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2006/01//
VL - 12
IS - 1
M3 - Article
SP - 99
EP - 106
PB - Nature Publishing Group
SN - 10788956
AB - Interleukin (IL)-13 is a major inducer of fibrosis in many chronic infectious and autoimmune diseases. In studies of the mechanisms underlying such induction, we found that IL-13 induces transforming growth factor (TGF)-β1 in macrophages through a two-stage process involving, first, the induction of a receptor formerly considered to function only as a decoy receptor, IL-13Rα2. Such induction requires IL-13 (or IL-4) and tumor necrosis factor (TNF)-α. Second, it involves IL-13 signaling through IL-13Rα2 to activate an AP-1 variant containing c-jun and Fra-2, which then activates the TGFB1 promoter. In vivo, we found that prevention of IL-13Rα2 expression reduced production of TGF-β1 in oxazolone-induced colitis and that prevention of IL-13Rα2 expression, Il13ra2 gene silencing or blockade of IL-13Rα2 signaling led to marked downregulation of TGF-β1 production and collagen deposition in bleomycin-induced lung fibrosis. These data suggest that IL-13Rα2 signaling during prolonged inflammation is an important therapeutic target for the prevention of TGF-β1–mediated fibrosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-13
KW - FIBROSIS
KW - COLLAGEN diseases
KW - AUTOIMMUNE diseases
KW - TRANSFORMING growth factors-beta
KW - MACROPHAGES
KW - TUMOR necrosis factor
N1 - Accession Number: 19438554; Fichtner-Feigl, Stefan 1 Strober, Warren 2; Email Address: wstrober@niaid.nih.gov Kawakami, Koji 3 Puri, Raj K. 3 Kitani, Atsushi 2; Affiliation: 1: Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA 2: Department of Surgery, University of Regensburg Medical Center, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany 3: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Building 29B, 2NN10, 29 Lincoln Drive MSC 4555, Bethesda, Maryland 20892, USA; Source Info: Jan2006, Vol. 12 Issue 1, p99; Subject Term: INTERLEUKIN-13; Subject Term: FIBROSIS; Subject Term: COLLAGEN diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: TRANSFORMING growth factors-beta; Subject Term: MACROPHAGES; Subject Term: TUMOR necrosis factor; Number of Pages: 8p; Illustrations: 7 Diagrams; Document Type: Article
L3 - 10.1038/nm1332
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lange, Susan
AU - Malli, Suzanne
T1 - Implanted device + MRI = trouble?
JO - Nursing
JF - Nursing
Y1 - 2006/01//
VL - 36
IS - 1
M3 - Article
SP - 75
EP - 75
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article presents precautions to be taken on administration off magnetic resonance imaging (MRI) in a patient who has an artificial implantation device. One should also make sure that the patient's primary care provider knows about the device, then document this. There should be an involvement of the patient's physician who is monitoring the implant during MRI procedures. When the patient is having a device implanted, he or she should be explained MRI procedures, stress should also be laid that he must always inform the MRI staff about his device before undergoing an MRI.
KW - MAGNETIC resonance imaging
KW - ARTIFICIAL implants
KW - DIAGNOSTIC imaging
KW - MEDICAL care
KW - PRIMARY care (Medicine)
KW - IMAGING systems in medicine
N1 - Accession Number: 19399176; Lange, Susan 1 Malli, Suzanne 1; Affiliation: 1: Analyst-Consultants, Center for Devices and Radiological Health.; Source Info: Jan2006, Vol. 36 Issue 1, p75; Subject Term: MAGNETIC resonance imaging; Subject Term: ARTIFICIAL implants; Subject Term: DIAGNOSTIC imaging; Subject Term: MEDICAL care; Subject Term: PRIMARY care (Medicine); Subject Term: IMAGING systems in medicine; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106390106
T1 - Device safety. Implanted device + MRI = trouble?
AU - Lange S
AU - Malli S
Y1 - 2006/01//
N1 - Accession Number: 106390106. Language: English. Entry Date: 20060203. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Electric Stimulation -- Equipment and Supplies
KW - Magnetic Resonance Imaging -- Adverse Effects
KW - Patient Safety
KW - Prostheses and Implants
KW - Patient Education
SP - 75
EP - 75
JO - Nursing
JF - Nursing
JA - NURSING
VL - 36
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 16395033.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106434281
T1 - Guest editorial: what is the NCLEX really testing?
AU - Stuart GW
Y1 - 2006/01//
N1 - Accession Number: 106434281. Language: English. Entry Date: 20060505. Revision Date: 20150818. Publication Type: Journal Article; editorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0401075.
KW - Education, Nursing
KW - Educational Measurement
KW - Licensure, Nursing
KW - NCLEX Examination
KW - Clinical Competence -- Standards
KW - Health Care Errors -- Prevention and Control
KW - Health Services Needs and Demand
KW - Nursing Practice, Evidence-Based -- Education
KW - Psychiatric Nursing -- Education
KW - Research, Nursing -- Education
KW - United States
SP - 1
EP - 2
JO - Nursing Outlook
JF - Nursing Outlook
JA - NURS OUTLOOK
VL - 54
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0029-6554
AD - Professor, Medical University of South Carolina, College of Nursing, 99 Jonathan Lucas St, Charleston, SC 29425; bcsharp@ahrq.gov
U2 - PMID: 16487767.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tomashek, Kay M.
AU - Crouse, Chadd J.
AU - Iyasu, Solomon
AU - Johnson, Christopher H.
AU - Flowers, Lisa M.
T1 - A comparison of morbidity rates attributable to conditions originating in the perinatal period among newborns discharged from United States hospitals, 1989–90 and 1999–2000.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2006/01//
VL - 20
IS - 1
M3 - Article
SP - 24
EP - 34
PB - Wiley-Blackwell
SN - 02695022
AB - Perinatal conditions account for 60% of US neonatal deaths, yet little is known about rates of morbidity attributable to these conditions. To estimate these rates, we analysed newborn hospital discharges from the National Hospital Discharge Survey. We used International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes to classify discharge diagnoses among a weighted, nationally representative sample of newborns discharged from short-stay, non-federal US hospitals. We compared overall and cause-specific morbidity rates attributable to perinatal conditions (ICD-9-CM 760.0–779.9), as well as the average length of hospital stay among newborn discharges during 1989–90 and 1999–2000. The overall newborn morbidity rate declined from 36.3% in 1989–90 to 33.7% in 1999–2000 ( P < 0.01), despite significant increases in high-risk births. The decline can be attributed to significant decreases in the reported rates of jaundice, fetal distress, birth trauma and birth asphyxia. Rates of jaundice decreased from 15.7% to 13.4% ( P < 0.01). The average length of stay decreased among newborns with no morbid condition (2.37–2.04 days, P < 0.001) and among those with one perinatal condition (3.11–2.51, P < 0.001), but increased among those with multiple perinatal conditions (8.43–9.98, P < 0.05). Morbidity rates among newborns discharged from US hospitals declined. Shorter newborn hospital stays may have resulted in fewer cases of jaundice being diagnosed before discharge. Stricter diagnostic criteria and changes in obstetric practices may have led to a decline in the rates of fetal distress, birth trauma and birth asphyxia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEWBORN infants -- Diseases
KW - DISEASES -- Risk factors
KW - PERINATAL death
KW - HOSPITALS -- Admission & discharge
KW - UNITED States
KW - birth trauma
KW - intrapartum asphyxia
KW - jaundice
KW - length of stay
KW - neonatal morbidity
KW - time trends
N1 - Accession Number: 19381832; Tomashek, Kay M. 1; Email Address: kct9@cdc.goc Crouse, Chadd J. 2 Iyasu, Solomon 3 Johnson, Christopher H. 2 Flowers, Lisa M. 2; Affiliation: 1: Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta GA 2: Information Technology, Statistics and Surveillance Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta GA 3: OCTAP, Division of Pediatric Drug Development (HFD-960), Center for Drug Evaluation and Research, Food and Drug Administration, Rockville MD, USA; Source Info: Jan2006, Vol. 20 Issue 1, p24; Subject Term: NEWBORN infants -- Diseases; Subject Term: DISEASES -- Risk factors; Subject Term: PERINATAL death; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: UNITED States; Author-Supplied Keyword: birth trauma; Author-Supplied Keyword: intrapartum asphyxia; Author-Supplied Keyword: jaundice; Author-Supplied Keyword: length of stay; Author-Supplied Keyword: neonatal morbidity; Author-Supplied Keyword: time trends; Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1111/j.1365-3016.2006.00690.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shatin, Deborah
AU - Rawson, Nigel S. B.
AU - Curtis, Jeffrey R.
AU - Braun, M. Miles
AU - Martin, Carolyn K.
AU - Moreland, Larry W.
AU - Becker, Angela F.
AU - Patkar, Nivedita M.
AU - Allison, Jeroan J.
AU - Saag, Kenneth G.
T1 - Documented tuberculin skin testing among infliximab users following a multi-modal risk communication interventions.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2006/01//
VL - 15
IS - 1
M3 - Article
SP - 11
EP - 18
SN - 10538569
AB - Purpose Following its licensure, tuberculosis (TB) was reported as a potential adverse effect of infliximab. Subsequently, the product circular was changed to recommend tuberculin skin testing before patients received infliximab, which was reinforced by several risk communication efforts. The aim of this study was to evaluate patterns and predictors of documented tuberculin skin testing in patients before and after manufacturer, federal, and academic risk communications. Methods Patients administered infliximab were identified from 11 health plans located throughout the United States, and claims data were examined to determine whether the patients had received a tuberculin skin test. Patients were divided into three cohorts depending on the timing of their first infliximab treatment in relation to the risk communication efforts. Results The overall tuberculin skin testing rate doubled from 15.4% in the first cohort to 30.9% in the last cohort, while the rate of pre-infliximab treatment testing increased from 0 to 27.7% (Chi-squared test for trend, p < 0.0001 for both). Tuberculin skin testing rates were significantly higher in women, those with a diagnosis of rheumatoid or psoriatic arthritis, and those with a rheumatologist as prescriber. After multivariable analysis, only rheumatologist remained significantly associated with tuberculin skin testing. Conclusions Although the tuberculin skin testing rate was relatively low overall, tuberculin skin testing doubled over 30 months of ongoing risk communication efforts and under ascertainment likely occurred. We also found variation in the tuberculin skin testing rate associated with physician specialty. This study demonstrates a significant change in patient care following risk communication efforts. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64709012; Shatin, Deborah 1; Rawson, Nigel S. B. 1; Curtis, Jeffrey R. 2; Braun, M. Miles 3; Martin, Carolyn K. 1; Moreland, Larry W. 2; Becker, Angela F. 2; Patkar, Nivedita M. 2; Allison, Jeroan J. 2; Saag, Kenneth G. 2; Affiliations: 1: Center for Health Care Policy and Evaluation, Minneapolis, MN, USA; 2: Center for Education and Research on Therapeutics (CERTs) of Musculoskeletal Disorders, University of Alabama at Birmingham, Birmingham, AL, USA; 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: Jan2006, Vol. 15 Issue 1, p11; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1132
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106432754
T1 - Datapoints. State-administered spending on mental health services by type of service.
AU - Buck JA
AU - Mark TL
Y1 - 2006/01//
N1 - Accession Number: 106432754. Language: English. Entry Date: 20060428. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Mental Health Services -- Economics
KW - State Health Plans -- Economics
KW - Descriptive Statistics
KW - Health Care Costs
KW - United States
KW - Human
SP - 29
EP - 29
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 57
IS - 1
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, 6-1061, Rockville, MD 20857; jeff.buck@samhsa.hhs.gov
U2 - PMID: 16399959.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Buchalla, Rainer
AU - Begley, Timothy H.
T1 - Characterization of gamma-irradiated polyethylene terephthalate by liquid-chromatography–mass-spectrometry (LC–MS) with atmospheric-pressure chemical ionization (APCI)
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2006/01//
VL - 75
IS - 1
M3 - Article
SP - 129
EP - 137
SN - 0969806X
AB - Abstract: Low-molecular-weight (low-MW) constituents of polyethylene terephthalate (PET), irradiated with 60Co gamma rays at 25 and 50kGy, were analyzed by HPLC–MS with atmospheric-pressure chemical ionization (APCI). Consistent with earlier results, the concentrations of the major compounds that are present in the non-irradiated PET do not change perceptibly. However, we find a small but significant increase in terephthalic acid ethylester, from less than 1mg/kg in the non-irradiated control to ca. 2mg/kg after 50kGy, which has not been described before. The finding is important because it gives an impression of the sensitivity of the analytical method. Additionally, it shows that even very radiation-resistant polymers can form measurable amounts of low-MW radiolysis products. The potential and limitations of LC–MS for the analysis of radiolysis products and unidentified migrants are briefly discussed in the context of the question: How can we validate our analytical methods for unknown analytes? [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THERMOPLASTICS
KW - POLYETHYLENE terephthalate
KW - CHROMATOGRAPHIC analysis
KW - RADIATION
KW - Ionizing radiation
KW - Liquid-chromatography–mass-spectrometry
KW - Polyethylene terephthalate
KW - Radiolysis products
N1 - Accession Number: 19059014; Buchalla, Rainer; Email Address: rainer.buchalla@kcl.ac.uk Begley, Timothy H. 1; Affiliation: 1: US Food and Drug Administration, Division of Chemistry Research and Environmental Review, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Jan2006, Vol. 75 Issue 1, p129; Subject Term: THERMOPLASTICS; Subject Term: POLYETHYLENE terephthalate; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: RADIATION; Author-Supplied Keyword: Ionizing radiation; Author-Supplied Keyword: Liquid-chromatography–mass-spectrometry; Author-Supplied Keyword: Polyethylene terephthalate; Author-Supplied Keyword: Radiolysis products; NAICS/Industry Codes: 325220 Artificial and Synthetic Fibers and Filaments Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.radphyschem.2005.05.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19059014&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Komolprasert, V.
AU - Diel, Todd
AU - Sadler, G.
T1 - Gamma irradiation of yellow and blue colorants in polystyrene packaging materials
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2006/01//
VL - 75
IS - 1
M3 - Article
SP - 149
EP - 160
SN - 0969806X
AB - Abstract: The effect of 10- and 20-kGy gamma irradiation was studied on chromophtal yellow 2RLTS (Yellow 110-2, 3, 4, 5-tetrachloro-6-cyanobenzoic acid) and Irgalite Blue GBP (copper (II) phthalocyanine blue) colorants, which were added to polystyrene (PS) material used to package food prior to irradiation. Analytical results obtained suggest that irradiation did not generate any new chemicals in the PS polymer containing either yellow or blue colorant at a concentration of up to 1% (w/w). Both yellow and blue colorants are relatively stable to gamma irradiation. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IRRADIATION
KW - RADIATION
KW - CHEMICAL terrorism
KW - PAPER chemicals
KW - Gamma irradiation
KW - Polystyrene
KW - Colorant
N1 - Accession Number: 19059016; Komolprasert, V. 1,2; Email Address: vanee.komolprasert@cfsan.fda.gov Diel, Todd 2 Sadler, G. 2; Affiliation: 1: Division of Food Processing and Packaging, US Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA 2: National Center for Food Safety and Technology/Illinois Institute of Technology, 6502 S. Archer Road, Summit-Argo, IL 60501, USA; Source Info: Jan2006, Vol. 75 Issue 1, p149; Subject Term: IRRADIATION; Subject Term: RADIATION; Subject Term: CHEMICAL terrorism; Subject Term: PAPER chemicals; Author-Supplied Keyword: Gamma irradiation; Author-Supplied Keyword: Polystyrene; Author-Supplied Keyword: Colorant; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.radphyschem.2005.04.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dayton, Andrew I.
T1 - Beyond open access: open discourse, the next great equalizer.
JO - Retrovirology
JF - Retrovirology
Y1 - 2006/01//
VL - 3
M3 - Article
SP - 55
EP - 3
PB - BioMed Central
SN - 17424690
AB - The internet is expanding the realm of scientific publishing to include free and open public debate of published papers. Journals are beginning to support web posting of comments on their published articles and independent organizations are providing centralized web sites for posting comments about any published article. The trend promises to give one and all access to read and contribute to cutting edge scientific criticism and debate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Retrovirology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERNET
KW - PERIODICAL publishing
KW - PUBLISHERS & publishing
KW - WEBSITES
KW - WORLD Wide Web
N1 - Accession Number: 30740409; Dayton, Andrew I. 1; Email Address: dayton@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, HFM 315 FDA/CBER, 1401 Rockville Pike, Rockville, MD, 20852-1448, USA; Source Info: 2006, Vol. 3, p55; Subject Term: INTERNET; Subject Term: PERIODICAL publishing; Subject Term: PUBLISHERS & publishing; Subject Term: WEBSITES; Subject Term: WORLD Wide Web; NAICS/Industry Codes: 517110 Wired Telecommunications Carriers; NAICS/Industry Codes: 519130 Internet Publishing and Broadcasting and Web Search Portals; NAICS/Industry Codes: 511120 Periodical Publishers; NAICS/Industry Codes: 511130 Book Publishers; NAICS/Industry Codes: 511190 Other publishers; NAICS/Industry Codes: 511199 All Other Publishers; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1186/1742-4690-3-55
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2009-16806-010
AN - 2009-16806-010
AU - Buehler, Janice A.
AU - Malone, Maureen
AU - Majerus-Wegerhoff, Janis M.
ED - Lee, Helen J.
ED - Winters, Charlene A.
ED - Lee, Helen J., (Ed)
ED - Winters, Charlene A., (Ed)
T1 - Patterns of responses to symptoms in rural residents: The Symptom-Action-Time-Line process.
T2 - Rural nursing: Concepts, theory, and practice, 2nd ed.
Y1 - 2006///
SP - 129
EP - 137
CY - New York, NY, US
PB - Springer Publishing Co
SN - 0-8261-6955-4
SN - 978-0-8261-6955-6
N1 - Accession Number: 2009-16806-010. Partial author list: First Author & Affiliation: Buehler, Janice A.; College of Nursing, Montana State University-Bozeman, Bozeman, MT, US. Release Date: 20100301. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8261-6955-4, Paperback; 978-0-8261-6955-6, Paperback. Language: English. Major Descriptor: Grounded Theory; Health Behavior; Illness Behavior; Rural Environments; Symptoms. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study. References Available: Y. Page Count: 9.
AB - How people identify, evaluate, and respond to symptoms is an important determinant of their health and illness behavior (Lenz, 1984). An increasing amount of literature addresses health behaviors of rural people (Lee, 1991; Long, 1993; Long & Weinert, 1989; Moon & Graybird, 1982; Weinert & Long, 1990). However, little information is available on the patterns of responses of rural people to symptom occurrence signifying actual or potential health problems. In addition, there is a paucity of information on health behaviors of certain rural groups, specifically, women and Plains Indians. Although actual processes of health-seeking behavior are not delineated in most research of rural health behaviors, some patterns are evident. A survey of health risk prevalence in rural Montana (Moon & Graybird, 1982) revealed that participants believed in self-responsibility for health. Lee (1991) noted that the quality of hardiness may be responsible for some rural dwellers' delay in seeking assistance from the professional health care system when symptoms of illness appear. Rural people were viewed as delaying health care until they were very ill, thus often needing hospitalization at the point care was sought (Long, 1993; Long & Weinert, 1989; Rosenblatt & Moscovice, 1982; Weinert & Long, 1990). Studies on responses to symptom occurrence, not specific to rural people, have been conducted by behavioral and social scientists. Mechanic (1960) stated that possible responses to illness include discretionary inaction, the use of medicines, seeking professional care, and using a lay network. Suchman (1966) described individual responses to symptom occurrence as proceeding in this sequential pattern: (1) the Symptom Experience Stage, (2) Assumption of Sick Role Stage, (3) Medical Care Contact Stage, and (4) Dependent Patient Role Stage. Segall and Goldstein (1989) noted that lay persons clearly do routinely self-evaluate and self-treat many of their health problems as a part of daily living and that the nature and extent of these self-care practices are not well understood. They concluded it is not clear whether self-care behavior is equally prevalent among different social groups, whether self-care is used for both health maintenance and the treatment of illness, and whether self-care is used only in response to selected symptomatic conditions. The qualitative method of grounded theory was used in this study (Glaser & Strauss, 1967). Grounded theory provides a means of understanding behavioral patterns from the perspective of the participants. Both Native American and Caucasian farm/ranch women used the symptom- action-time-line process to respond to symptoms of actual or potential health problems. The process consists of four stages in which symptoms are identified and actions are taken to move to a desired state of health. The stages are (a) symptom identification, (b) self-care, (c) lay resources, and (d) professional resources. Each stage has a time period (time-line) in which the participant takes actions in response to a symptom, evaluates the effectiveness of the actions in resolving the symptom, and decides whether to go on to the next stage. Time periods during stages are dependent on the intensity, duration, and amount of interference in function caused by the symptom and may be minutes, days, or years. The first stage, symptom identification, is the stimulus leading to the other stages. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rural residents
KW - response patterns
KW - symptom patterns
KW - Symptom-Action-Time-Line process
KW - 2006
KW - Grounded Theory
KW - Health Behavior
KW - Illness Behavior
KW - Rural Environments
KW - Symptoms
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-16806-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Pezzin, Liliana E.
AU - Pollak, Robert A.
AU - Schone, Barbara
AD - Medical College of WI
AD - Washington U in St Louis
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - Marital Disruption, Step Children, and Transfers to the Elderly
JO - Schweizerische Zeitschrift fur Volkswirtschaft und Statistik/Swiss Journal of Economics and Statistics
JF - Schweizerische Zeitschrift fur Volkswirtschaft und Statistik/Swiss Journal of Economics and Statistics
Y1 - 2006///Special Issue
SP - 103
EP - 106
SN - 03039692
N1 - Accession Number: 0887682; Keywords: Children; Divorce; Elderly; Family; Marital; Marriage; Publication Type: Journal Article; Update Code: 200702
N2 - Divorce has become an important part of life for many in Europe and North America. For the United States, it has been estimated that approximately one half of all marriages will end in divorce. As a consequence of the high incidence of divorce and nonmarital childbirth, and subsequent (re)marriage, the traditional nuclear family is rapidly being augmented by new, more complex family structures. A substantial literature within the social sciences has focused on the effects of nontraditional family structures on children. A smaller literature has focused on the positive effects of marriage and negative effects of divorce on adult men and adult women. Relatively little is known about the effects of nontraditional family structures on adult children's transfers to their disabled elderly parents. In this study we investigate the effects of divorce, remarriage and step children on intergenerational living arrangements and adult children's time and cash transfers to their disabled, unpartnered elderly parents. Data for this analysis are drawn from matched observations from waves one and two of the Assets and Health Dynamics of the Elderly (AHEAD) survey, a nationally-representative sample of community-based persons aged 70 and older in 1993 from the United States. We limited our sample to wave 2 respondents who reported in wave two their marital status as widowed or as divorced/separated, who had at least one child, and who reported having difficulty with at least one basic or instrumental activity of daily living. The unit of analysis is the child.
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Fertility; Family Planning; Child Care; Children; Youth J13
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://www.sjes.ch/published.php
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0887682&site=ehost-live&scope=site
UR - http://www.sjes.ch/published.php
DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Sieber, William K.
AU - Bennett, James S.
AU - Wouhib, Abera
AU - Gonzalez, Joe Fred, Jr.
AU - Katzoff, Myron J.
AU - Shulman, Stanley A.
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
AD - National Institute for Health Statistics, Centers for Disease Control and Prevention
AD - National Institute for Health Statistics, Centers for Disease Control and Prevention
AD - National Institute for Health Statistics, Centers for Disease Control and Prevention
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
A2 - Wilson, Alyson G.
A2 - Wilson, Gregory D.
A2 - Olwell, David H.
T1 - Approaches to Modeling the Concentration Field for Adaptive Sampling of Contaminants during Site Decontamination
T2 - Statistical Methods in Counterterrorism: Game Theory, Modeling, Syndromic Surveillance, and Biometric Authentication
PB - New York:
PB - Springer
Y1 - 2006///
SP - 215
EP - 235
N1 - Accession Number: 0965363; Reviewed Book ISBN: 978-0-387-32904-8; ; Publication Type: Collective Volume Article; Update Code: 200804
KW - National Security and War H56
KW - Health: Government Policy; Regulation; Public Health I18
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0965363&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Wagner, Nicholas J.
AU - Quatrano, Louis A.
AU - Nicholson, Carol E.
T1 - Translating civilian and defense technologies for pediatric critical care and rehabilitation research.
JO - Technology & Health Care
JF - Technology & Health Care
Y1 - 2006/01//
VL - 14
IS - 1
M3 - Article
SP - 49
EP - 58
PB - IOS Press
SN - 09287329
AB - A conference sponsored by the National Institutes of Health (NIH) and the Defense Advanced Research Projects Agency (DARPA) titled "Translating Civilian and Defense Technologies for Pediatric Critical Care and Rehabilitation Research" was held on May 16th and 17th, 2005 in Rockville, Maryland. A summary of presentations from the conference is provided. Topics presented addressed: advances in monitoring and imaging devices used in the pediatric intensive care unit, regulatory issues and recent technological developments relating to medical devices for children, the new role that virtual reality is playing in rehabilitation medicine, and the evolving future of assistive devices for rehabilitation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Technology & Health Care is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRICS
KW - CRITICAL care medicine
KW - MEDICAL rehabilitation
KW - MEDICAL technology
KW - VIRTUAL reality
KW - critical care
KW - medical technology
KW - Pediatrics
KW - rehabilitation
N1 - Accession Number: 20237130; Wagner, Nicholas J. 1 Quatrano, Louis A. 2; Email Address: quatranl@exchange.nih.gov Nicholson, Carol E. 2; Affiliation: 1: Medical College of Georgia, Augusta, GA, USA 2: National Center for Medical Rehabilitation Research, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA; Source Info: 2006, Vol. 14 Issue 1, p49; Subject Term: PEDIATRICS; Subject Term: CRITICAL care medicine; Subject Term: MEDICAL rehabilitation; Subject Term: MEDICAL technology; Subject Term: VIRTUAL reality; Author-Supplied Keyword: critical care; Author-Supplied Keyword: medical technology; Author-Supplied Keyword: Pediatrics; Author-Supplied Keyword: rehabilitation; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20237130&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106441422
T1 - A multivariate evaluation of an office ergonomic intervention using longitudinal data.
AU - Swanson NG
AU - Sauter SL
Y1 - 2006/01//
N1 - Accession Number: 106441422. Language: English. Entry Date: 20060519. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101163424.
KW - Keyboards
KW - Equipment Design
KW - Musculoskeletal System -- Pathology
KW - Occupational-Related Injuries -- Etiology
KW - Stress, Occupational
KW - Ergonomics
KW - Models, Theoretical
KW - Descriptive Statistics
KW - Intervention Trials
KW - Regression
KW - Statistical Significance
KW - Prospective Studies
KW - Questionnaires
KW - Random Assignment
KW - Factor Analysis
KW - Data Analysis Software
KW - Coefficient Alpha
KW - Occupational Health
KW - Human
SP - 3
EP - 17
JO - Theoretical Issues in Ergonomics Science
JF - Theoretical Issues in Ergonomics Science
JA - THEOR ISSUES ERGON SCI
VL - 7
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The present study used longitudinal data from an alternative keyboard intervention study to test pathways between physical, work organization/psychosocial, stress and musculoskeletal symptom factors postulated by Sauter and Swanson in their ecological model of musculoskeletal disorders in office work. Data on work organization, stress and musculoskeletal symptoms were collected from 189 office workers at baseline and 1 year later. After baseline, an alternative keyboard was provided to half of the participants, while the remaining participants continued using a conventional keyboard. Regression analyses on the Year 1-baseline difference scores revealed significant relationships for keyboard condition and musculoskeletal symptoms, keyboard condition and work organization and work organization and stress. However, the relationships between work organization and musculoskeletal symptoms, keyboard condition and stress and stress and musculoskeletal symptoms were not significant. Thus, the analyses provided partial support for the tested pathways.
SN - 1463-922X
AD - National Institute for Occupational Safety and Health, Taft Laboratories MSC-24, 4676 Columbia Parkway, Cincinnati, Ohio 45226; nws3@cdc.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106441422&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tsuji, Joyce S.
AU - Maynard, Andrew D.
AU - Howard, Paul C.
AU - John T. James
AU - Chiu-Wing Lam
AU - Warheit, David B.
AU - Santamariak, Annette B.
T1 - Research Strategies for Safety Evaluation of Nanomaterials, Part IV: Risk Assessment of Nanoparticles.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/01//
VL - 89
IS - 1
M3 - Article
SP - 42
EP - 50
PB - Oxford University Press / USA
SN - 10966080
AB - Nanoparticles are small-scale substances (<100 nm) with unique properties and, thus, complex exposure and health risk implications. This symposium review summarizes recent findings in exposure and toxicity of nanoparticles and their application for assessing human health risks. Characterization of airborne particles indicates that exposures will depend on particle behavior (e.g., disperse or aggregate) and that accurate, portable, and cost-effective measurement techniques are essential for understanding exposure. Under many conditions, dermal penetration of nanoparticles may be limited for consumer products such as sunscreens, although additional studies are needed on potential photooxidation products, experimental methods, and the effect of skin condition on penetration. Carbon nanotubes apparently have greater pulmonary toxicity (inflammation, granuloma) in mice than fine-scale carbon graphite, and their metal content may affect toxicity. Studies on TiO2 and quartz illustrate the complex relationship between toxicity and particle characteristics, including surface coatings, which make generalizations (e.g., smaller particles are always more toxic) incorrect for some substances. These recent toxicity and exposure data, combined with therapeutic and other related literature, are beginning to shape risk assessments that will be used to regulate the use of nanomaterials in consumer products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Health risk assessment
KW - Toxicity testing
KW - Nanoparticles
KW - Airborne infection
KW - Inflammation
KW - Granuloma
KW - exposure assessment
KW - nanoparticles
KW - nanotechnology
KW - risk assessment
N1 - Accession Number: 20605838; Tsuji, Joyce S. 1; Email Address: tsujij@exponent.com; Maynard, Andrew D. 2; Howard, Paul C. 3; John T. James 4; Chiu-Wing Lam 4; Warheit, David B. 5; Santamariak, Annette B. 6; Affiliations: 1: Exponent, Bellevue, Washington 98007; 2: Woodrow Wilson International Center for Scholars, Washington, DC 20004-3027; 3: National Center for Toxicological Research and National Toxicology Program Center for Phototoxicology, U.S. Food & Drug Administration, Jefferson, Arkansas 72079; 4: National Aeronautics and Space Administration, Houston, Texas 77058; 5: DuPont Haskell Laboratory, Newark, Delaware 19714; 6: Environ International, Houston, Texas 77002; Issue Info: Jan2006, Vol. 89 Issue 1, p42; Thesaurus Term: RESEARCH; Thesaurus Term: Health risk assessment; Thesaurus Term: Toxicity testing; Subject Term: Nanoparticles; Subject Term: Airborne infection; Subject Term: Inflammation; Subject Term: Granuloma; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: nanoparticles; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1093/toxsci/kfi339
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20605838&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105849349
T1 - Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers.
AU - Simak J
AU - Gelderman MP
Y1 - 2006/01//
N1 - Accession Number: 105849349. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8709027.
KW - Blood Component Transfusion -- Adverse Effects
KW - Blood Preservation -- Adverse Effects
KW - Cell Membrane
KW - Cell Physiology
KW - Technology
KW - Biological Markers -- Blood
KW - Inflammation -- Blood
KW - Inflammation -- Etiology
KW - Inflammation -- Pathology
KW - Neoplasm Metastasis
KW - Neoplasms -- Blood
KW - Neoplasms -- Pathology
KW - Thrombosis -- Blood
KW - Thrombosis -- Etiology
KW - Thrombosis -- Pathology
SP - 1
EP - 26
JO - Transfusion Medicine Reviews
JF - Transfusion Medicine Reviews
JA - TRANSFUS MED REV
VL - 20
IS - 1
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Cell membrane microparticles (MPs) circulate in the blood of healthy donors, and their elevated counts have been documented in various pathologies. Microparticles are phospholipid microvesicles of 0.05 to 1.5 microm in size, containing certain membrane proteins of their parental cells. Thus, different phenotypes of MPs derived from platelets, blood cells, endothelial cells, and some other cell types have been identified in plasma. Microparticles are released by various stimuli including shear stress, complement attack, or proapoptotic stimulation. Microparticle release is a highly controlled process and likely independent from metabolic energy. Elevated MPs in various diseases indicate their diagnostic importance, particularly in vascular pathologies. Moreover, MPs in blood possess a broad spectrum of biologic activities. Microparticles may facilitate cell-to-cell interactions, induce cell signaling, or even transfer receptors between different cell types. The physiological roles of MPs in various tissue defense processes have been suggested and the pathophysiologic implications of MPs in thrombosis, inflammation, cancer metastasis, or response to pathogens have been proposed. This is important for transfusion medicine because MPs are present in both plasma and cellular blood products. Thus, the investigation of potentially pathogenic effects of MPs in blood products and of MP release associated with blood product processing and storage have yet to come.Copyright © 2006 by Elsevier Inc.
SN - 0887-7963
AD - Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. jan.simak@fda.hhs.gov
U2 - PMID: 16373184.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105849349&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Ruta, Martin
AU - Epstein, Jay S.
T1 - Paid vs. unpaid donors.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2006/01//
VL - 90
IS - 1
M3 - Other
SP - 63
EP - 70
PB - Wiley-Blackwell
SN - 00429007
AB - The article focuses on the international forum concerning paid and unpaid blood donations. Australia’s commitment to non-remunerated blood donation is embedded in legislation in the various jurisdictions of the Australian federation, which forbids payment for blood or tissue donation. In Germany, there exists three different donation systems that handle donors differently, which includes Red Cross Blood Services, University and community Blood Services and Commercial plasmapheresis centers. Italy and Norway are on the same stand, they do not pay to blood donors.
KW - BLOOD donors
KW - PAYMENT
KW - AUSTRALIA
KW - GERMANY
KW - ITALY
KW - NORWAY
N1 - Accession Number: 19065871; Ruta, Martin 1 Epstein, Jay S. 1; Email Address: epsteinj@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research US Food and Drug Administration 1401 Rockville Pike Rockville MD 20852 USA; Source Info: Jan2006, Vol. 90 Issue 1, p63; Subject Term: BLOOD donors; Subject Term: PAYMENT; Subject Term: AUSTRALIA; Subject Term: GERMANY; Subject Term: ITALY; Subject Term: NORWAY; Number of Pages: 8p; Document Type: Other
L3 - 10.1111/j.1423-0410.2005.00708.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19065871&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-22334-001
AN - 2006-22334-001
AU - Blitz, Cynthia L.
T1 - Predictors of Stable Employment Among Female Inmates in New Jersey: Implications for Successful Reintegration.
JF - Journal of Offender Rehabilitation
JO - Journal of Offender Rehabilitation
JA - J Offender Rehabil
Y1 - 2006///
VL - 43
IS - 1
SP - 1
EP - 22
CY - US
PB - Haworth Press
SN - 1050-9674
SN - 1540-8558
AD - Blitz, Cynthia L., Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2006-22334-001. Other Journal Title: Journal of Offender Counseling, Services & Rehabilitation. Partial author list: First Author & Affiliation: Blitz, Cynthia L.; Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Other Publishers: Taylor & Francis. Release Date: 20061211. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Conviction; Demographic Characteristics; Employment Status; Mental Health Services; Prisoners. Minor Descriptor: History; Human Females; Prediction; Reintegration. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 22. Issue Publication Date: 2006.
AB - The ability of inmates to secure stable, legal employment for themselves upon release from prison has been shown to be a crucial element for successful community reintegration. These individuals, however, often fail to find employment due to a multitude of personal, relational, structural, and institutional barriers. Formerly incarcerated women are particularly disadvantaged in this respect, given their high rates of psychiatric and substance abuse disorders, and history of domestic violence in conjunction with low educational attainment and limited employment skills. The main goal of the current study was to delineate the relative importance of a variety of personal factors as determinants of stable employment for female inmates. Data were collected as part of a population survey of female inmates in New Jersey (N = 908). Female inmates who volunteered to participate in this study were asked to complete a short survey that included questions about their educational and work histories, their work skills, as well as their history of need in and treatment for behavioral health services. Findings from this study underscore the importance of both education and treatment for behavioral health problems as key determinants of stable employment. Recommendations for possible interventions are addressed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - female inmates
KW - employment history before incarceration
KW - predictors of employment stability
KW - demographics
KW - personal circumstances
KW - treatment for behavioral health services
KW - conviction status
KW - 2006
KW - Criminal Conviction
KW - Demographic Characteristics
KW - Employment Status
KW - Mental Health Services
KW - Prisoners
KW - History
KW - Human Females
KW - Prediction
KW - Reintegration
KW - 2006
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20 MH66170. Other Details: Center for Mental Health Services & Criminal Justice Research. Recipients: No recipient indicated
DO - 10.1300/J076v43n01_01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22334-001&site=ehost-live&scope=site
UR - clblitz@rci.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22193-001
AN - 2006-22193-001
AU - Horwitz, Mark J.
T1 - Work-Related Trauma Effects in Child Protection Social Workers.
JF - Journal of Social Service Research
JO - Journal of Social Service Research
JA - J Soc Serv Res
Y1 - 2006///
VL - 32
IS - 3
SP - 1
EP - 18
CY - US
PB - Haworth Press
SN - 0148-8376
SN - 1540-7314
AD - Horwitz, Mark J., Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-22193-001. Partial author list: First Author & Affiliation: Horwitz, Mark J.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Taylor & Francis. Release Date: 20061211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Welfare; Emotional Trauma; Experiences (Events); Occupational Stress; Social Workers. Minor Descriptor: Job Satisfaction; Working Conditions. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: 2006.
AB - Child welfare workers are exposed to a variety of workplace events that could overwhelm them. This study examined whether negative workplace events were associated with workplace trauma effects amongst child welfare workers, and considered whether job support or job satisfaction moderated the influence of events on effects. Vicarious events were more highly associated with trauma effects (r = 0.54, p < 0.000) than were direct events (r = 0.28, p < 0.000), and neither job support nor job satisfaction moderated the relationship. Workplace trauma events accounted for substantial variability in workplace trauma effects (R² = 0.344) in the final regression model tested. The discussion addresses opportunities for increasing worker safety, methods for supporting workers in managing negative effects and implications for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work related trauma
KW - child protection
KW - social workers
KW - workplace events
KW - job satisfaction
KW - job support
KW - 2006
KW - Child Welfare
KW - Emotional Trauma
KW - Experiences (Events)
KW - Occupational Stress
KW - Social Workers
KW - Job Satisfaction
KW - Working Conditions
KW - 2006
DO - 10.1300/J079v32n03_01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22193-001&site=ehost-live&scope=site
UR - mhorwitz@crocker.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21091-001
AN - 2006-21091-001
AU - Kaida, Kosuke
AU - Ogawa, Keiko
AU - Matsuura, Noriko
AU - Takahashi, Masaya
AU - Hori, Tadao
T1 - Relationship between the habit of napping with self-awakening and generalized self-efficacy.
JF - Japanese Journal of Health Psychology
JO - Japanese Journal of Health Psychology
Y1 - 2006///
VL - 19
IS - 1
SP - 1
EP - 9
CY - Japan
PB - Waseda University/Faculty of Literature
SN - 0917-3323
SN - 2187-5529
N1 - Accession Number: 2006-21091-001. Partial author list: First Author & Affiliation: Kaida, Kosuke; Japan National Institute of Occupational Safety and Health, Japan. Release Date: 20070108. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: Japanese. Major Descriptor: Aging; Habits; Napping; Self-Control; Self-Efficacy. Minor Descriptor: Sleep Wake Cycle. Classification: Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: 2006.
AB - The relationship between generalized self-efficacy and afternoon napping with or without self-awakening, defined as waking up at a designated time decided before sleep, was investigated in elderly people. It has been reported that a short nap with self-awakening can reduce afternoon sleepiness and sleep inertia. The feeling of self-control over afternoon sleepiness may contribute to maintaining self-efficacy in daily life. In the present study, a questionnaire survey was conducted with 447 elderly people aged over 65 (74.3 ± 5.28). A one-way analysis of variance compared four groups of participants: regular napping, defined as taking a nap at the same time of the day, irregular napping, napping with self-awakening, and napping without self-awakening. The results suggest that regular napping was significantly related to higher self-efficacy, and moreover, that self-awakening also contributed to increasing self-efficacy. These results imply that the habit of regular napping with self-awakening would be a useful tool for promoting successful aging. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self efficacy
KW - self awakening
KW - waking
KW - sleep
KW - self control
KW - elderly
KW - napping
KW - habits
KW - 2006
KW - Aging
KW - Habits
KW - Napping
KW - Self-Control
KW - Self-Efficacy
KW - Sleep Wake Cycle
KW - 2006
DO - 10.11560/jahp.19.1_1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21091-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02044-001
AN - 2006-02044-001
AU - Swanson, N. G.
AU - Sauter, S. L.
T1 - A multivariate evaluation of an office ergonomic intervention using longitudinal data.
T3 - Theoretical Issues in Understanding Work-related Musculoskeletal Disorders Causation
JF - Theoretical Issues in Ergonomics Science
JO - Theoretical Issues in Ergonomics Science
JA - Theor Issues Ergon
Y1 - 2006/01//Jan-Feb, 2006
VL - 7
IS - 1
SP - 3
EP - 17
CY - United Kingdom
PB - Taylor & Francis
SN - 1463-922X
SN - 1464-536X
AD - Swanson, N. G., National Institute for Occupational Safety and Health, Taft Laboratories, MSC-24, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2006-02044-001. Partial author list: First Author & Affiliation: Swanson, N. G.; National Institute for Occupational Safety and Health, Taft Laboratories, Cincinnati, OH, US. Release Date: 20060522. Correction Date: 20160414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Intervention; Musculoskeletal Disorders; Organizational Characteristics; Stress. Minor Descriptor: Keyboards. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Musculoskeletal Symptom Survey; Job Stress Questionnaire DOI: 10.1037/t11381-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Jan-Feb, 2006.
AB - The present study used longitudinal data from an alternative keyboard intervention study to test pathways between physical, work organization/psychosocial, stress and musculoskeletal symptom factors postulated by Sauter and Swanson in their ecological model of musculoskeletal disorders in office work. Data on work organization, stress and musculoskeletal symptoms were collected from 189 office workers at baseline and 1 year later. After baseline, an alternative keyboard was provided to half of the participants, while the remaining participants continued using a conventional keyboard. Regression analyses on the Year 1-baseline difference scores revealed significant relationships for keyboard condition and musculoskeletal symptoms, keyboard condition and work organization and work organization and stress. However, the relationships between work organization and musculoskeletal symptoms, keyboard condition and stress and stress and musculoskeletal symptoms were not significant. Thus, the analyses provided partial support for the tested pathways. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - office ergonomic intervention
KW - musculoskeletal symptoms
KW - stress
KW - work organization
KW - keyboards
KW - 2006
KW - Human Factors Engineering
KW - Intervention
KW - Musculoskeletal Disorders
KW - Organizational Characteristics
KW - Stress
KW - Keyboards
KW - 2006
DO - 10.1080/14639220512331335124
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02044-001&site=ehost-live&scope=site
UR - nws3@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22256-001
AN - 2006-22256-001
AU - Eldred, Lois
AU - Cheever, Laura
AU - Parham-Hopson, Deborah
T1 - Accessing Care for U.S./Mexico Border Populations Living with HIV/AIDS: The Role of HRSA's HIV/AIDS Bureau and the Special Projects of National Significance.
JF - Journal of HIV/AIDS & Social Services
JO - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS Soc Serv
Y1 - 2006///
VL - 5
IS - 2
SP - 7
EP - 13
CY - US
PB - Haworth Press
SN - 1538-1501
AD - Eldred, Lois, Department of Health and Human Services, Health Resources Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2006-22256-001. Partial author list: First Author & Affiliation: Eldred, Lois; United States Department of Health and Human Services, Health Resources Services Administration, HIV/AIDS Bureau, Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20070312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Continuum of Care; Health Care Delivery; Health Care Services; HIV. Minor Descriptor: Case Management; Counseling. Classification: Immunological Disorders (3291); Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: 2006.
AB - The Health Resources Services Administration (HRSA) provides health-care to underserved areas in the U.S. and addresses disparities in health-care among U.S. populations. HRSA's Ryan White CARE Act provides HIV care and supportive services for persons with HIV and AIDS in the U.S. and its territories. Five projects were funded as Special Projects of National Significance (SPNS) from 2001-2005, to improve care and access to HIV services along the U.S.-Mexican Border. These projects developed culturally appropriate and innovative outreach strategies, expanded counseling and testing in border communities, assured continuity of care through intensive case management services and increased clinical capacity through provider training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Health Resources Services Administration
KW - health care
KW - HIV
KW - AIDS
KW - counseling
KW - intensive case management services
KW - continuity of care
KW - 2006
KW - AIDS
KW - Continuum of Care
KW - Health Care Delivery
KW - Health Care Services
KW - HIV
KW - Case Management
KW - Counseling
KW - 2006
DO - 10.1300/J187v05n02_03
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22256-001&site=ehost-live&scope=site
UR - LEldred@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10372-002
AN - 2006-10372-002
AU - Ursano, Robert J.
AU - Cerise, Frederick P.
AU - Demartino, Robert
AU - Reissman, Dori B.
AU - Shear, M. Katherine
T1 - The Impact of Disasters and Their Aftermath on Mental Health.
JF - The Journal of Clinical Psychiatry
JO - The Journal of Clinical Psychiatry
JA - J Clin Psychiatry
Y1 - 2006/01//
VL - 67
IS - 1
SP - 7
EP - 14
CY - US
PB - Physicians Postgraduate Press
SN - 0160-6689
N1 - Accession Number: 2006-10372-002. PMID: 16426082 Other Journal Title: Diseases of the Nervous System. Partial author list: First Author & Affiliation: Ursano, Robert J.; Center for the Study of Traumatic Stress of the Uniformed Services University of the Health Sciences, Bethesda, MD, US. Release Date: 20060905. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Column/Opinion. Language: English. Major Descriptor: Disasters; Health Care Delivery; Mental Health; Natural Disasters; Stress Reactions. Minor Descriptor: Emotional Trauma; Environmental Effects; Grief; Terrorism; Health Personnel. Classification: Environmental Issues & Attitudes (4070); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Page Count: 8. Issue Publication Date: Jan, 2006.
AB - In recent years, there has been an increased concern about wide-scale disasters, both natural and man-made, and their impact on the mental health of the population at large. In addition to the trauma of the disaster itself, the aftermath of the disaster, as the affected population tries to rebuild both literally and figuratively, can affect mental health as well. This article (presented in the form of a panel discussion with both clinical psychiatrists and public health officials) is focused on Hurricane Katrina, which hit the U.S. Gulf Coast in August 2005, but the concerns and challenges faced by health care personnel on the public and personal levels are similar to those in any wide-scale disaster or terrorist event that might affect our nation. When considering the impact of disasters on mental health, posttraumatic stress disorder (PTSD) may come immediately to mind, but disasters affect all parts of one's life, from grief at the loss of a loved one or home, to disruptions in access to health care and medications for chronic conditions (psychiatric or medical), to uncertainty regarding school for one's children, to name but a few. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - natural disasters
KW - man-made disasters
KW - impact
KW - aftermath
KW - trauma
KW - Hurricane Katrina
KW - Hurricane Rita
KW - health care personnel
KW - health care delivery
KW - terrorist events
KW - 2006
KW - Disasters
KW - Health Care Delivery
KW - Mental Health
KW - Natural Disasters
KW - Stress Reactions
KW - Emotional Trauma
KW - Environmental Effects
KW - Grief
KW - Terrorism
KW - Health Personnel
KW - 2006
DO - 10.4088/JCP.v67n0102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10372-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16401-002
AN - 2005-16401-002
AU - Short, Pamela Farley
AU - Mallonee, Erin L.
T1 - Income Disparities in the Quality of Life of Cancer Survivors.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2006/01//
VL - 44
IS - 1
SP - 16
EP - 23
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Short, Pamela Farley, 116 Henderson Building, University Park, PA, US, 16802
N1 - Accession Number: 2005-16401-002. PMID: 16365608 Partial author list: First Author & Affiliation: Short, Pamela Farley; Department of Health Policy and Administration, Pennsylvania State University, University Park, PA, US. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: World Congress of the International Health Economics Association, 5th, Jul, 2005, Barcelona, Spain. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Income (Economic); Neoplasms; Quality of Life. Minor Descriptor: Survivors. Classification: Cancer (3293). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Functional Assessment of Cancer Therapy-General; Short Form-12. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2006.
AB - Background: Studies of cancer survivors usually report positive correlations between income and health-related quality of life (QoL). These correlations cannot necessarily be interpreted as income disparities because earnings and income are affected by health, as well as the reverse. Objectives: The goal of this study was to quantify income disparities in QoL among cancer survivors by using instrumental variables (IV) to assess and, if necessary, correct for reverse causality. Methods: We constructed an instrumental variable for income from home ownership, sources of unearned income, marital status at diagnosis, and spousal characteristics. Then, we examined income's effect on QoL in regressions controlling for other clinical and demographic predictors of QoL. The data were from interviews in 2002 with a cohort of cancer survivors who were 25 to 62 years of age when diagnosed during 1997 to 1999. Measures: The Functional Assessment of Cancer Therapy-General (FACT-G) and the SF-12 measured QoL in multiple domains. Questions adapted from the Health and Retirement Study ascertained the ratio of annual family income to the poverty threshold in 2001. Results: Endogeneity tests were sensitive to assumptions of linearity for the income-QoL relationship and the choice of QoL measure. Consistently estimated income disparities were significant in all QoL models. The income elasticity of QoL ranged from 2% to 10%. Conclusions: There are income-related disparities in the QoL of cancer survivors that cannot be explained away by the effect of health on earnings. High-income patients are not only more likely to survive cancer, but they enjoy better QoL as survivors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - income disparities
KW - quality life
KW - cancer survivors
KW - causality
KW - 2006
KW - Income (Economic)
KW - Neoplasms
KW - Quality of Life
KW - Survivors
KW - 2006
DO - 10.1097/01.mlr.0000188986.84819.3a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16401-002&site=ehost-live&scope=site
UR - PamShort@psu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09416-002
AN - 2006-09416-002
AU - Hinden, Beth R.
AU - Biebel, Kathleen
AU - Nicholson, Joanne
AU - Henry, Alexis
AU - Katz-Leavy, Judith
T1 - A Survey of Programs for Parents with Mental Illness and their Families: Identifying Common Elements to Build the Evidence Base.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2006/01//
VL - 33
IS - 1
SP - 21
EP - 38
CY - Germany
PB - Springer
SN - 1094-3412
AD - Hinden, Beth R., Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-09416-002. PMID: 16636906 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Hinden, Beth R.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20060905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Tampa meeting of the 15th Annual Research Conference for Children's Mental Health, 15th, Mar, 2002. Conference Note: Data from this article were presented at the aforementioned conference. Major Descriptor: Family; Mental Disorders; Mental Health Services; Parents. Minor Descriptor: Treatment Effectiveness Evaluation; Treatment. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 18. Issue Publication Date: Jan, 2006.
AB - Little is known about the effectiveness of interventions for families living with parental mental illness. Existing interventions offer information about successfully implemented treatments, which may demonstrate effectiveness in research. In the current study, directors of programs for parents with mental illness and their families were interviewed. Qualitative analyses revealed noteworthy similarities with respect to target population; funding; community context; agency context; mission, theoretical orientation, and assumptions; locus of care and essential services; desired outcomes; and moderators. Program similarities were identified to provide parameters for research, and to contribute to the development of testable hypotheses. Family-centered, strengths-based approaches were identified across program directors as critical to intervention success. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental mental illness
KW - families
KW - treatment
KW - intervention effectiveness
KW - 2006
KW - Family
KW - Mental Disorders
KW - Mental Health Services
KW - Parents
KW - Treatment Effectiveness Evaluation
KW - Treatment
KW - 2006
U1 - Sponsor: Center for Mental Health Services, Substance Abuse and Mental Health Services Administration. Grant: 99M00481801D. Recipients: No recipient indicated
DO - 10.1007/s11414-005-9007-x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09416-002&site=ehost-live&scope=site
UR - Alexis.Henry@umassmed.edu
UR - Betsy.Hinden@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10532-006
AN - 2006-10532-006
AU - Graham, Garth N.
AU - Kim, Soo
AU - James, Barbara
AU - Reynolds, Gladys
AU - Buggs, Georgia
AU - Hunter, Mildred
AU - Davis, Willie Jr.
AU - Welsh, Valerie
AU - Bourne, Khandi
AU - Payne, Kermit
AU - Primas, Marion E.
AU - Burwell, Audrey
T1 - Benefits of Standardized Diabetes and Hypertension Screening Forms at Community Screening Events.
JF - Health Promotion Practice
JO - Health Promotion Practice
JA - Health Promot Pract
Y1 - 2006/01//
VL - 7
IS - 1
SP - 26
EP - 33
CY - US
PB - Sage Publications
SN - 1524-8399
SN - 1552-6372
AD - Graham, Garth N., Office of Minority Health, 1101 Wooton Parkway, Rockville, MD, US, 20852
N1 - Accession Number: 2006-10532-006. PMID: 16410418 Partial author list: First Author & Affiliation: Graham, Garth N.; Office of Minority Health, Office of Public Health and Science, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20070305. Correction Date: 20111031. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Diabetes; Health Screening; Hypertension; Minority Groups. Classification: Promotion & Maintenance of Health & Wellness (3365); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2006.
AB - The objectives of this project were to (a) assess hypertension and diabetes screening data collection practices and guidelines and (b) develop and test standardized screening forms for use at minority community- and faith-based screening events. Project Phase I involved resource assessment and the development of a set of screening forms and guidelines containing a core data set for both hypertension and diabetes. These were then tested during Phase II at predetermined community-based screening events throughout the United States. Community- and faith-based health screening programs are important in reaching and informing individuals in selected communities about their health and health risks. This study demonstrated the development of a standard tool that was effective in conducting African American community-based screening programs for hypertension and diabetes by community-based organizations. These activities are effective to obtain standardized information on individuals within the communities served. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - standardized diabetes benefits
KW - hypertension screening forms
KW - community screening event
KW - guidelines
KW - 2006
KW - Communities
KW - Diabetes
KW - Health Screening
KW - Hypertension
KW - Minority Groups
KW - 2006
DO - 10.1177/1524839905283890
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10532-006&site=ehost-live&scope=site
UR - ggraham@osophs.dhhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02290-005
AN - 2006-02290-005
AU - Owens, Pamela L.
AU - Kerker, Bonnie D.
AU - Zigler, Edward
AU - Horwitz, Sarah M.
T1 - Vision and Oral Health Needs of Individuals with Intellectual Disability.
JF - Mental Retardation and Developmental Disabilities Research Reviews
JO - Mental Retardation and Developmental Disabilities Research Reviews
JA - Ment Retard Dev Disabil Res Rev
Y1 - 2006///
VL - 12
IS - 1
SP - 28
EP - 40
CY - US
PB - John Wiley & Sons
SN - 1080-4013
SN - 1098-2779
AD - Owens, Pamela L., Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-02290-005. PMID: 16435325 Other Journal Title: Developmental Disabilities Research Reviews. Partial author list: First Author & Affiliation: Owens, Pamela L.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20060327. Correction Date: 20081208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Dental Treatment; Health Service Needs; Treatment Planning; Vision. Minor Descriptor: Health Promotion; Prevention; Oral Health; Intellectual Development Disorder. Classification: Mental Retardation (3256); Health & Mental Health Services (3370). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 13. Issue Publication Date: 2006.
AB - Over the past 20 years, there has been an increased emphasis on health promotion, including prevention activities related to vision and oral health, for the general population, but not for individuals with intellectual disability (ID). This review explores what is known about the prevalence of vision problems and oral health conditions among individuals with ID, presents a rationale for the increased prevalence of these conditions in the context of service utilization, and examines the limitations of the available research. Available data reveal a wide range of prevalence estimates for vision problems and oral health conditions, but all suggest that these conditions are more prevalent among individuals with ID compared with the general population, and disparities exist in the receipt of preventive and early treatment for these conditions for individuals with ID. Recommendations for health improvement in these areas include better health planning and monitoring through standardized population-based data collection and reporting and increased emphasis on health promotion activities and early treatment in the healthcare system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vision problems
KW - oral health needs
KW - intellectual disability
KW - health promotion
KW - prevention strategies
KW - treatment planning
KW - Mental Retardation
KW - 2006
KW - Dental Treatment
KW - Health Service Needs
KW - Treatment Planning
KW - Vision
KW - Health Promotion
KW - Prevention
KW - Oral Health
KW - Intellectual Development Disorder
KW - 2006
U1 - Sponsor: Yale University, Special Olympics, Inc. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: 5T32-MH15783; 5T32-MH19545. Recipients: No recipient indicated
DO - 10.1002/mrdd.20096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02290-005&site=ehost-live&scope=site
UR - povvens@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-00908-015
AN - 2006-00908-015
AU - Buck, Jeffrey A.
AU - Mark, Tami L.
AU - Harold, D. C.
AU - Tanielian, Terri L.
AU - Kilbourne, Amy
ED - Harold, D. C.
ED - Tanielian, Terri L.
ED - Kilbourne, Amy
T1 - State-administered spending on mental health services by type of service.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/01//
VL - 57
IS - 1
SP - 29
EP - 29
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Buck, Jeffrey A., Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, 6-1061, Rockville, MD, US, 20857
N1 - Accession Number: 2006-00908-015. PMID: 16399959 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060227. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: Jan, 2006.
AB - A broader picture of total spending by states on mental health services can be derived from estimates of national spending for mental health and substance abuse services. The estimates show spending by type of provider, such as general hospitals, and by type of service-inpatient, outpatient, residential, or prescription drugs. This type of calculation provides a different perspective on spending, because many providers, such as hospitals, deliver multiple types of services. Although the percentage of spending going to inpatient care declined, the amount remained quite stable. The amount for outpatient care increased considerably, but the percentage increased only modestly. Larger proportional and absolute increases went for retail psychotropic drugs and residential care. Furthermore, although the combined percentage for inpatient care and residential care decreased, these two types of services still accounted for more than half of state-administered spending for mental health services in 2001. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state administered spending
KW - mental health services
KW - substance abuse services
KW - 2006
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Mental Health Services
KW - 2006
DO - 10.1176/appi.ps.57.1.29
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00908-015&site=ehost-live&scope=site
UR - jeff.buck@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22256-003
AN - 2006-22256-003
AU - Zúñiga, María Luisa
AU - Organista, Kurt C.
AU - Scolari, Rosana
AU - Olshefsky, Alisa M.
AU - Schulhof, Robyn
AU - Colón, Madeline
T1 - Exploring Care Access Issues for Mexican-Origin Latinos Living with HIV in the San Diego/Tijuana Border Region.
JF - Journal of HIV/AIDS & Social Services
JO - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS Soc Serv
Y1 - 2006///
VL - 5
IS - 2
SP - 37
EP - 54
CY - US
PB - Haworth Press
SN - 1538-1501
AD - Zúñiga, María Luisa, UCSD Division of Community Pediatrics, University of California, San Diego, 9500 Gilman Drive, Mail Code 0927, La Jolla, CA, US, 92093
N1 - Accession Number: 2006-22256-003. Partial author list: First Author & Affiliation: Zúñiga, María Luisa; University of California, San Diego (UCSD), Division of Community Pediatrics, La Jolla, CA, US. Other Publishers: Taylor & Francis. Release Date: 20070312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Health Care Delivery; Health Care Utilization; HIV; Stigma. Classification: Immunological Disorders (3291); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: 2006.
AB - Health access issues and dynamics of health access for Latinos living with HIV on the U.S.-Mexico border have not been well-characterized. Health service utilization and related issues unique to seropositive HIV Latino populations were explored and findings are presented from two focus groups with Mexican women and men living with HIV in the San Diego/Tijuana U.S.-Mexico border. Cross-cutting border issues (same as Trans-border issues) included lack of continuity in HIV treatment options in Mexico, provider and social stigma of AIDS patients in Mexico, and fears of crossing the border to the U.S. for appointments. Findings indicate a need for coordinated bi-national efforts at HIV/AIDS research and services for border region inhabitants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV
KW - health
KW - health service utilization
KW - social stigma
KW - AIDS patients
KW - 2006
KW - AIDS
KW - Health Care Delivery
KW - Health Care Utilization
KW - HIV
KW - Stigma
KW - 2006
DO - 10.1300/J187v05n02_05
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22256-003&site=ehost-live&scope=site
UR - mzuniga@ucsd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02044-002
AN - 2006-02044-002
AU - Carayon, P.
AU - Haims, M. C.
AU - Hoonakker, P. L. T.
AU - Swanson, N. G.
T1 - Teamwork and musculoskeletal health in the context of work organization interventions in office and computer work.
T3 - Theoretical Issues in Understanding Work-related Musculoskeletal Disorders Causation
JF - Theoretical Issues in Ergonomics Science
JO - Theoretical Issues in Ergonomics Science
JA - Theor Issues Ergon
Y1 - 2006/01//Jan-Feb, 2006
VL - 7
IS - 1
SP - 39
EP - 69
CY - United Kingdom
PB - Taylor & Francis
SN - 1463-922X
SN - 1464-536X
AD - Carayon, P., Department of Industrial Engineering, University of Wisconsin-Madison, 575 WARF Building, 610 Walnut Street, Madison, WI, US, 53726
N1 - Accession Number: 2006-02044-002. Partial author list: First Author & Affiliation: Carayon, P.; Department of Industrial Engineering, University of Wisconsin-Madison, Madison, WI, US. Release Date: 20060522. Correction Date: 20130114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Carayon, P. Major Descriptor: Computers; Cooperation; Intervention; Musculoskeletal Disorders; Occupational Stress. Minor Descriptor: Human Factors Engineering; Psychosocial Factors; Working Conditions. Classification: Human Factors Engineering (4010). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Michigan Organizational Assessment Questionnaire DOI: 10.1037/t01581-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 31. Issue Publication Date: Jan-Feb, 2006.
AB - Work-related musculoskeletal disorders (WRMDs) are increasingly becoming more prevalent in the US workforce. The introduction of computer-based technology seems to have been accompanied by an increase in WRMDs. Computer-based technology seems to intensify work so much as to create stressful and unhealthy working conditions. In this paper, the role and impact of various psychosocial work stressors, including teamwork, in work organization interventions aimed at reducing and/or preventing WRMDs among office/computer workers are examined. Both the process and the content of the work organization interventions rely on teamwork. The results show the importance of teamwork in influencing stress and musculoskeletal discomfort. In particular, the psychosocial factors of open group process and group cohesiveness were among the most important predictors of anxiety and musculoskeletal discomfort. The results show that teamwork affects both psychosocial stress outcomes (anxiety) as well as musculoskeletal discomfort. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - musculoskeletal health
KW - teamwork
KW - work organization interventions
KW - computer work
KW - psychosocial work stressors
KW - 2006
KW - Computers
KW - Cooperation
KW - Intervention
KW - Musculoskeletal Disorders
KW - Occupational Stress
KW - Human Factors Engineering
KW - Psychosocial Factors
KW - Working Conditions
KW - 2006
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Grant: Cooperative Agreement U60/CCU512018-01. Recipients: Carayon, P. (Prin Inv)
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Grant: Cooperative Agreement U60/CCU512983-01. Recipients: Smith, M.J. (Prin Inv); Carayon, P. (Prin Inv)
DO - 10.1080/14639220512331335151
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02044-002&site=ehost-live&scope=site
UR - carayon@engr.wisc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22237-004
AN - 2006-22237-004
AU - Winters, Ken C.
AU - DeWolfe, Jerome
AU - Graham, Donald
AU - St. Cyr, Wehnona
T1 - Screening American Indian Youth for Referral to Drug Abuse Prevention and Intervention Services.
JF - Journal of Child & Adolescent Substance Abuse
JO - Journal of Child & Adolescent Substance Abuse
JA - J Child Adolesc Subst Abuse
Y1 - 2006///
VL - 16
IS - 1
SP - 39
EP - 52
CY - US
PB - Haworth Press
SN - 1067-828X
SN - 1547-0652
AD - Winters, Ken C., Department of Psychiatry, University of Minnesota, F282/2A West, 2450 Riverside Avenue, Minneapolis, MN, US, 55454
N1 - Accession Number: 2006-22237-004. Other Journal Title: Journal of Adolescent Chemical Dependency. Partial author list: First Author & Affiliation: Winters, Ken C.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, US. Other Publishers: Taylor & Francis. Release Date: 20061218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Winters, Ken C. Major Descriptor: American Indians; Drug Abuse; Drug Rehabilitation; Psychometrics; Test Construction. Minor Descriptor: Screening Tests. Classification: Clinical Psychological Testing (2224); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Indian Health Service-Personal Experience Screening Questionnaire; Personal Experience Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2006.
AB - The development and psychometric properties of a brief screening tool for use with American Indian youth suspected of abusing substances is described. The Indian Health Service-Personal Experience Screening Questionnaire (IHS-PESQ) is a brief questionnaire that screens for drug abuse problem severity, response distortion tendencies, and psychosocial risk factors. The psychometric properties of the problem severity scale are favorable when tested in reservation-based American Indian students (grades 6-12). The paper also describes the role of the IHS-PESQ within a prevention, intervention and treatment referral system designed for American Indian youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indian youths
KW - Indian Health Service Personal Experience Screening Questionnaire
KW - test development
KW - psychometric properties
KW - drug abuse
KW - drug abuse prevention
KW - intervention services
KW - 2006
KW - American Indians
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Psychometrics
KW - Test Construction
KW - Screening Tests
KW - 2006
U1 - Sponsor: Indian Health Service, Aberdeen Area. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse. Grant: DA05104. Recipients: No recipient indicated
U1 - Sponsor: Saint Paul Foundation. Recipients: Winters, Ken C.
DO - 10.1300/J029v16n01_04
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22237-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04838-003
AN - 2006-04838-003
AU - Moy, Ernest
AU - Smith, Colleen Ryan
AU - Johansson, Patrik
AU - Andrews, Roxanne
T1 - Gaps in data for American Indians and Alaska natives in the national healthcare disparities report.
JF - American Indian and Alaska Native Mental Health Research
JO - American Indian and Alaska Native Mental Health Research
JA - Am Indian Alsk Native Ment Health Res
Y1 - 2006///
VL - 13
IS - 1
SP - 52
EP - 69
CY - US
PB - National Center for American Indian and Alaska Native Mental Health Research
SN - 0893-5394
SN - 1533-7731
AD - Moy, Ernest, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-04838-003. PMID: 17602397 Other Journal Title: White Cloud Journal of American Indian Mental Health; White Cloud Journal of American Indian/Alaska Native Mental Health. Partial author list: First Author & Affiliation: Moy, Ernest; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20060522. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Health Care Services; Health Care Utilization; Quality of Care. Minor Descriptor: Data Collection. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Tests & Measures: National Survey on Drug Use and Health; Medical Expenditure Panel Survey; National Immunization Survey; National Ambulatory Medical Care Survey; National Hospital Discharge Survey; National Health Interview Survey. Methodology: Empirical Study. References Available: Y. Page Count: 18. Issue Publication Date: 2006.
AB - The aim of this study was to identify and quantify gaps in health care data for American Indians and Alaska Natives. Findings indicate that only 42% of measures of health care quality and access tracked in the National Healthcare Disparities Report could be used to assess disparities among American Indians and Alaska Natives. Patient safety data was especially limited. Data from American Indians and Alaska Natives need to be improved to allow better targeting of interventions to reduce health care disparities and monitoring the success of these activities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Alaska Natives
KW - American Indians
KW - health care data
KW - healthcare disparities
KW - health care quality & access
KW - cancer
KW - diabetes
KW - respiratory & renal disease
KW - heart disease
KW - mental health
KW - substance abuse
KW - 2006
KW - Alaska Natives
KW - American Indians
KW - Health Care Services
KW - Health Care Utilization
KW - Quality of Care
KW - Data Collection
KW - 2006
DO - 10.5820/aian.1301.2006.52
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04838-003&site=ehost-live&scope=site
UR - emoy@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03446-007
AN - 2006-03446-007
AU - Bell, Jennifer L.
AU - Grushecky, Shawn T.
T1 - Evaluating the effectiveness of a logger safety training program.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2006///
VL - 37
IS - 1
SP - 53
EP - 61
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Bell, Jennifer L., Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2006-03446-007. PMID: 16516237 Partial author list: First Author & Affiliation: Bell, Jennifer L.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, US. Release Date: 20060403. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Turnover; Injuries; Occupational Safety; Personnel Training; Program Evaluation. Minor Descriptor: Business Organizations; Organizational Effectiveness. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: 2006.
AB - Introduction: Logger safety training programs are rarely, if ever, evaluated as to their effectiveness in reducing injuries. Method: Workers' compensation claim rates were used to evaluate the effectiveness of a logger safety training program, the West Virginia Loggers' Safety Initiative (LSI). Results: There was no claim rate decline detected in the majority (67%) of companies that participated in all 4 years of the LSI. Furthermore, their rate did not differ from the rest of the WV logging industry that did not participate in the LSI. Worker turnover was significantly related to claim rates; companies with higher turnover of employees had higher claim rates. Companies using feller bunchers to harvest trees at least part of the time had a significantly lower claim rate than companies not using them. Companies that had more inspections per year had lower claim rates. Conclusions: High injury rates persist even in companies that receive safety training; high employee turnover may affect the efficacy of training programs. The logging industry should be encouraged to facilitate the mechanization of logging tasks, to address barriers to employee retention, and to increase the number of in-the-field performance monitoring inspections. Impact on industry: There are many states whose logger safety programs include only about 48 hours of safe work practices training. These states may look to West Virginia's expanded training program (the LSI) as a model for their own programs. However, the LSI training may not be reaching loggers due to the delay in administering training to new employees and high levels of employee turnover. Regardless of training status, loggers' claim rates decline significantly the longer they work for a company. It may be that high injury rates in the state of West Virginia would be best addressed by finding ways to encourage and facilitate companies to become more mechanized in their harvesting practices, and to increase employee tenure. Increasing the number of yearly performance inspections may also be a venue to reduce claim rates. Future research could investigate in better detail the working conditions of West Virginia loggers and identify barriers to job tenure, particularly for workers whose primary job task is chainsaw operation. A larger-scale study of the effect of performance monitoring inspections on claim rates is also warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - program evaluation
KW - logger safety training program
KW - occupational safety
KW - injuries
KW - employee turnover
KW - business organizations
KW - effectiveness
KW - 2006
KW - Employee Turnover
KW - Injuries
KW - Occupational Safety
KW - Personnel Training
KW - Program Evaluation
KW - Business Organizations
KW - Organizational Effectiveness
KW - 2006
DO - 10.1016/j.jsr.2005.10.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03446-007&site=ehost-live&scope=site
UR - SGrushec@wvu.edu
UR - JBell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-16840-010
AN - 2005-16840-010
AU - Wiefferink, Carin H.
AU - Reijneveld, Sijmen A.
AU - de Wijs, Joop
AU - Swagerman, Margreet
AU - Campman, Dorien
AU - Paulussen, Theo G. W.
T1 - Screening for psychosocial problems in 5-6-year olds: A randomised controlled trial of routine health assessments.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 2006/01//
VL - 60
IS - 1
SP - 57
EP - 65
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
AD - Wiefferink, Carin H., TNO Prevention and Health, P.O. Box 2215, 2301 CE, Leiden, Netherlands
N1 - Accession Number: 2005-16840-010. PMID: 16332471 Partial author list: First Author & Affiliation: Wiefferink, Carin H.; TNO Prevention and Health, Leiden, Netherlands. Release Date: 20060109. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Pediatricians; Pediatrics; Psychological Assessment; Psychosocial Factors; Screening. Minor Descriptor: Education; Health. Classification: Professional Education & Training (3410). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adulthood (18 yrs & older) (300). Tests & Measures: Child Behavior Checklist. Methodology: Clinical Trial; Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2006.
AB - Objective: Children's psychosocial problems are often not identified accurately. The present study addresses the effect of training of Child Health Doctors (CHDs) in a structured method to identify psychosocial problems on the accuracy of this identification in children aged 5-6. Method: The study was a randomised controlled trial (RCT) with a baseline and two follow-up measurements. A volunteer sample of 58 CHDs participated, randomly assigned to intervention or control condition. CHDs selected a population-based sample of 5-6-year-old children (n = 6375). Results: The first follow-up showed that sensitivity had improved by 9% and specificity by 5% in the intervention condition, especially in children with severe problems (odds ratio = 3.7; 95% confidence interval: 1.2-11.8). The second follow-up showed a decrease in sensitivity and specificity in both conditions. Conclusion: The training improves identification of psychosocial problems, especially severe ones, although the availability of time and resources also influences the accuracy with which psychosocial problems are identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - screening
KW - psychosocial problems
KW - health assessments
KW - training effects
KW - Child Health Doctors
KW - 2006
KW - Pediatricians
KW - Pediatrics
KW - Psychological Assessment
KW - Psychosocial Factors
KW - Screening
KW - Education
KW - Health
KW - 2006
DO - 10.1016/j.pec.2004.11.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-16840-010&site=ehost-live&scope=site
UR - ch.wiefferink@pg.tno.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22285-001
AN - 2006-22285-001
AU - Cook, Judith A.
AU - Mulkern, Virginia
AU - Grey, Dennis D.
AU - Burke-Miller, Jane
AU - Blyler, Crystal R.
AU - Razzano, Lisa A.
AU - Onken, Steven J.
AU - Balser, Richard M.
AU - Gold, Paul B.
AU - Shafer, Michael S.
AU - Kaufmann, Caroline L.
AU - Donegan, Kate
AU - Chow, Clifton M.
AU - Steigman, Pamela A.
T1 - Effects of local unemployment rate on vocational outcomes in a randomized trial of supported employment for individuals with psychiatric disabilities.
JF - Journal of Vocational Rehabilitation
JO - Journal of Vocational Rehabilitation
JA - J Vocat Rehabil
Y1 - 2006///
VL - 25
IS - 2
SP - 71
EP - 84
CY - Netherlands
PB - IOS Press
SN - 1052-2263
SN - 1878-6316
AD - Cook, Judith A., University of Illinois at Chicago, Department of Psychiatry, 1601 West Taylor Street, 4th Floor, M/C 912, Chicago, IL, US, 60612
N1 - Accession Number: 2006-22285-001. Partial author list: First Author & Affiliation: Cook, Judith A.; University of Illinois at Chicago, Department of Psychiatry, Chicago, IL, US. Release Date: 20070226. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Occupational Status; Supported Employment; Unemployment. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Positive and Negative Syndrome Scale DOI: 10.1037/t05056-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2006.
AB - The purpose of this study was to explore the effects of local unemployment rates on evidence-based supported employment (SE) programs tailored for people with psychiatric disabilities. Participants (n = 1,273) from 7 states in the US were randomly assigned to experimental SE or services as usual/comparison conditions and followed for 24 months. Mixed-effects random regression analysis found that both local unemployment rate and study condition were significant predictors of competitive employment and working 40 or more hours per month. An interaction between study condition and unemployment rate was found, in which participants in areas with low unemployment receiving best practice SE had consistently better outcomes than all others. However, even in areas with high unemployment, those who received evidence-based SE had outcomes superior to those in the control condition. This confirms the influence of local labor market forces on individuals with psychiatric disabilities participating in vocational rehabilitation programs. It also suggests that those who are attempting to return to work in areas with weak local economies are likely to fare especially poorly if they are not receiving high quality SE interventions. Thus, use of evidence-based SE can help to ameliorate the effects of high unemployment on work outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - local unemployment rates
KW - vocational outcomes
KW - supported employment programs
KW - psychiatric disabilities
KW - 2006
KW - Mental Disorders
KW - Occupational Status
KW - Supported Employment
KW - Unemployment
KW - 2006
U1 - Sponsor: Center for Mental Health Services/Substance Abuse and Mental Health Services Administration. Grant: Cooperative Agreement SM51820. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22285-001&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04324-007
AN - 2006-04324-007
AU - Brounstein, Paul J.
AU - Gardner, Stephen E.
AU - Backer, Thomas E.
T1 - Research to practice: Efforts to bring effective prevention to every community.
JF - The Journal of Primary Prevention
JO - The Journal of Primary Prevention
JA - J Prim Prev
Y1 - 2006/01//
VL - 27
IS - 1
SP - 91
EP - 109
CY - Germany
PB - Springer
SN - 0278-095X
SN - 1573-6547
AD - Brounstein, Paul J., CMHS, 1 Choke Cherry Road, Room 6-1087, Rockville, MD, US, 20857
N1 - Accession Number: 2006-04324-007. PMID: 16421654 Partial author list: First Author & Affiliation: Brounstein, Paul J.; Unites States Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, US. Release Date: 20060911. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Government Agencies; Mental Health Services; Prevention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 19. Issue Publication Date: Jan, 2006.
AB - This manuscript describes the pioneering efforts of the Substance Abuse and Mental Health Services Administration's attempts to catalog knowledge, support, and further evaluate the application of evidence-based prevention. The paper begins with a discussion of scientific inquiry, including discussion of cause-and-effect relationships, theory that is useful in explaining those relationships, and suggestion of the opportunities and limitations of research in these and other areas. The authors then describe a system that has been introduced by the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Substance Abuse Prevention (CSAP) to systematically access and review applied research efforts in drug abuse prevention and related fields. In addition to identifying the key elements of this National Registry of Effective Prevention Programs (NREPP), the authors provide a brief history of prior efforts that have led us to this point. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Substance Abuse and Mental Health Services Administration
KW - evidence based prevention
KW - 2006
KW - Evidence Based Practice
KW - Government Agencies
KW - Mental Health Services
KW - Prevention
KW - 2006
DO - 10.1007/s10935-005-0024-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04324-007&site=ehost-live&scope=site
UR - Paul.Brounstein@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22036-018
AN - 2006-22036-018
AU - Kissin, Wendy
AU - McLeod, Caroline
AU - Sonnefeld, Joseph
AU - Stanton, Arlene
T1 - Experiences of a national sample of qualified addiction specialists who have and have not prescribed buprenorphine for opioid dependence.
JF - Journal of Addictive Diseases
JO - Journal of Addictive Diseases
JA - J Addict Dis
Y1 - 2006///
VL - 25
IS - 4
SP - 91
EP - 103
CY - US
PB - Haworth Press
SN - 1055-0887
SN - 1545-0848
AD - Kissin, Wendy, Westate, 1700 Research Boulevard, Rockville, MD, US, 20850
N1 - Accession Number: 2006-22036-018. PMID: 17088229 Other Journal Title: Advances in Alcohol & Substance Abuse. Partial author list: First Author & Affiliation: Kissin, Wendy; Westate, Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20070430. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: American Association for the Treatment of Opioid Dependence, Oct, 2004, US. Conference Note: These data were presented in part at the aforementioned conference, as well as the American Public Health Association Annual Meeting, November 2004; and the European Opiate Addiction Treatment Association European Conference, November 2004. Major Descriptor: Drug Dependency; Narcotic Antagonists; Opiates; Physicians; Prescribing (Drugs). Minor Descriptor: Drug Therapy; Buprenorphine. Classification: Substance Abuse & Addiction (3233); Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: 2006.
AB - The limited availability of medication-assisted treatment has created a treatment gap leaving many opioid dependent individuals without access to appropriate treatment. Survey data from a national random sample of 545 addictions physicians with waivers to provide buprenorphine treatment under The Drug Addiction Treatment Act of 2000 are presented. During the first year, an estimated 63,204 opioid dependent patients were treated with buprenorphine; many were dependent on prescription opioids and were new to drug treatment. Prescribing physicians reported high treatment effectiveness and patient satisfaction, with minimal adverse reactions or evidence of diversion. However, many waivered physicians had not provided buprenorphine treatment. Prescribers identified challenges such as induction logistics, recordkeeping requirements, the 30-patient limit, DEA involvement, and limited patient compliance. Buprenorphine treatment could potentially reduce the treatment gap by providing safe and effective treatment for opioid dependence and by attracting patients who do not typically seek care at opioid treatment programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - buprenorphine
KW - opioid dependence
KW - medication-assisted treatment
KW - addiction specialist physicians
KW - drug prescribing
KW - 2006
KW - Drug Dependency
KW - Narcotic Antagonists
KW - Opiates
KW - Physicians
KW - Prescribing (Drugs)
KW - Drug Therapy
KW - Buprenorphine
KW - 2006
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, US. Grant: 277-00-6111. Other Details: DATA Waiver Program. Recipients: No recipient indicated
DO - 10.1300/J069v25n04_09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22036-018&site=ehost-live&scope=site
UR - wendykissin@westat.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07380-013
AN - 2006-07380-013
AU - Goldstrom, Ingrid D.
AU - Campbell, Jean
AU - Rogers, Joseph A.
AU - Lambert, David B.
AU - Blacklow, Beatrice
AU - Henderson, Marilyn J.
AU - Manderscheid, Ronald W.
T1 - National Estimates for Mental Health Mutual Support Groups, Self-Help Organizations, and Consumer-Operated Services.
T3 - Depression in Primary Care
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2006/01//
VL - 33
IS - 1
SP - 92
EP - 103
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Goldstrom, Ingrid D., Center for Mental Health Services, 1 Choke Cherry Road, Room 2-1081, Rockville, MD, US, 20857
N1 - Accession Number: 2006-07380-013. PMID: 16240075 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Goldstrom, Ingrid D.; Survey and Analysis Branch, Division of State and Community Systems Development, Center for Mental Health Services, Substance Abuse, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20060626. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Integrated Services; Mental Health; Organizations; Self-Help Techniques; Support Groups. Minor Descriptor: Estimation; Family Members. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 2006.
AB - The authors report on a 2002 national survey of mental health mutual support groups (MSG) and self-help organizations (SHO) run by and for mental health consumers and/or family members, and consumer-operated services (COS). They found 7467 of these groups and organizations--3315 MSGs, 3019 SHOs, and 1133 COSs--greatly eclipsing the number of traditional mental health organizations (4546). MSGs reported that 41,363 people attended their last meetings. SHOs reported a total of 1,005,400 members. COSs reported serving 534,551 clients/members in 1 year. The array of services and supports provided within each of these types (MSG, SHO, COS) is reported, and implications for the President's New Freedom Commission on Mental Health recommendations are explicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - national estimates
KW - mental health
KW - mutual support groups
KW - self help organizations
KW - consumer operated services
KW - family members
KW - 2006
KW - Integrated Services
KW - Mental Health
KW - Organizations
KW - Self-Help Techniques
KW - Support Groups
KW - Estimation
KW - Family Members
KW - 2006
DO - 10.1007/s10488-005-0019-x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07380-013&site=ehost-live&scope=site
UR - Ingrid.Goldstrom@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2005-15501-012
AN - 2005-15501-012
AU - Ruff, Todd
T1 - Evaluation of a radar-based proximity warning system for off-highway dump trucks.
JF - Accident Analysis and Prevention
JO - Accident Analysis and Prevention
JA - Accid Anal Prev
Y1 - 2006/01//
VL - 38
IS - 1
SP - 92
EP - 98
CY - Netherlands
PB - Elsevier Science
SN - 0001-4575
AD - Ruff, Todd, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery, Spokane, WA, US, 99207
N1 - Accession Number: 2005-15501-012. PMID: 16129405 Partial author list: First Author & Affiliation: Ruff, Todd; National Institute for Occupational Safety and Health, Spokane Research Laboratory, Spokane, WA, US. Release Date: 20060117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Motor Vehicles; Safety Devices; Technology; Warnings. Classification: Transportation (4090). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2006.
AB - A radar-based proximity warning system was evaluated by researchers at the Spokane Research Laboratory of the National Institute for Occupational Safety and Health to determine if the system would be effective in detecting objects in the blind spots of an off-highway dump truck. An average of five fatalities occur each year in surface mines as a result of an equipment operator not being aware of a smaller vehicle, person or change in terrain near the equipment. Sensor technology that can detect such obstacles and that also is designed for surface mining applications is rare. Researchers worked closely with the radar system manufacturer to test and modify the system on large, off-highway dump trucks at a surface mine over a period of 2 years. The final system was thoroughly evaluated by recording video images from a camera on the rear of the truck and by recording all alarms from the rear-mounted radar. Data show that the system reliably detected small vehicles, berms, people and other equipment. However, alarms from objects that posed no immediate danger were common, supporting the assertion that sensor-based systems for proximity warning should be used in combination with other devices, such as cameras, that would allow the operator to check the source of any alarm. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - radar
KW - warning system
KW - highway trucks
KW - sensor technology
KW - 2006
KW - Motor Vehicles
KW - Safety Devices
KW - Technology
KW - Warnings
KW - 2006
DO - 10.1016/j.aap.2005.07.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2005-15501-012&site=ehost-live&scope=site
UR - ter5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-15003-003
AN - 2007-15003-003
AU - Curie, Charles G.
T1 - Health diplomacy in action: Helping Iraq rebuild its mental health system.
T3 - Iraqi mental health
JF - Journal of Muslim Mental Health
JO - Journal of Muslim Mental Health
JA - J Muslim Ment Health
Y1 - 2006///
VL - 1
IS - 2
SP - 109
EP - 116
CY - United Kingdom
PB - Taylor & Francis
SN - 1556-4908
SN - 1556-5009
AD - Curie, Charles G., Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2007-15003-003. Partial author list: First Author & Affiliation: Curie, Charles G.; Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: University of Michigan Press. Release Date: 20071029. Correction Date: 20111121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Iraq. Page Count: 8. Issue Publication Date: 2006.
AB - The task of helping Iraq rebuild its mental health system is health diplomacy in action, and an assignment to which the Substance Abuse and Mental Health Services Administration (SAMHSA) has pledged support. During my visit in 2004, I recognized that the vision for Iraqi mental health was not very different from the vision that has guided SAMHSA over the past years as we have worked to transform mental health care in America. That is why I made a commitment at that time for SAMHSA to assist Iraq's Ministry of Health with strategic planning and expertise. In partnership with other nations, federal agencies, and nongovernment organizations, we can help our colleagues in Iraq reestablish a vital, dynamic mental health care system that meets the needs of their citizens with compassion, respect, and dignity for evidence-based care and community-based services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health system
KW - Iraq
KW - health diplomacy
KW - rebuilding
KW - 2006
KW - Mental Health Services
KW - 2006
DO - 10.1080/15564900600980574
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15003-003&site=ehost-live&scope=site
UR - Mark.Weber@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09269-005
AN - 2007-09269-005
AU - Andrade, Joel T.
AU - Vincent, Gina M.
AU - Saleh, Fabian M.
T1 - Juvenile sex offenders: A complex population.
JF - Journal of Forensic Sciences
JO - Journal of Forensic Sciences
JA - J Forensic Sci
Y1 - 2006/01//
VL - 51
IS - 1
SP - 163
EP - 167
CY - United Kingdom
PB - Blackwell Publishing
SN - 0022-1198
SN - 1556-4029
AD - Andrade, Joel T., Bridgewater State Hospital, 20 Administration Road, Bridgewater, MA, US, 02324
N1 - Accession Number: 2007-09269-005. PMID: 16423244 Partial author list: First Author & Affiliation: Andrade, Joel T.; University of Massachusetts Medical School, Correctional Mental Health Program, Bridgewater State Hospital, Bridgewater, MA, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071112. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Juvenile Delinquency; Mental Disorders; Sex Offenses. Minor Descriptor: Comorbidity; Criminals; Victimization; Risk Assessment. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 5. Issue Publication Date: Jan, 2006.
AB - Individuals who engage in sexual offending behavior represent a heterogeneous population. Recent research has found some success in categorizing sexual offenders based on a number of variables, particularly the type of victim. For example, differences have been found between those offenders who victimize adults when compared with those who victimize children. However, the research in this area has been conducted predominantly with adult samples. As the adult sex offender literature has progressed, it has become evident that risk assessment, treatment effectiveness, and risk management are dependent on such offender characteristics. Unfortunately, the relevance to juveniles of characteristics deemed to be important with adult sex offenders is limited due to the complexity of developmental processes, particularly with respect to mental disorders and personality formation. As such, the formulation and implementation of treatment and risk management strategies that will be effective with juvenile sex offenders are challenging. The goal of this paper is to review some of the complexities inherent in the juvenile sex offender population by focusing on specific areas of complication, including: classification systems, comorbid paraphilias and other mental illnesses, and maladaptive personality traits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - juvenile sex offender
KW - heterogeneous population
KW - victims
KW - mental disorders
KW - risk assessment
KW - 2006
KW - Juvenile Delinquency
KW - Mental Disorders
KW - Sex Offenses
KW - Comorbidity
KW - Criminals
KW - Victimization
KW - Risk Assessment
KW - 2006
DO - 10.1111/j.1556-4029.2005.00010.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09269-005&site=ehost-live&scope=site
UR - joeltandrade@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-00903-010
AN - 2006-00903-010
AU - Bondi, Maris Ann
AU - Harris, Jeffrey R.
AU - Atkins, David
AU - French, Molly E.
AU - Umland, Beth
T1 - Employer coverage of clinical preventive services in the United States.
JF - American Journal of Health Promotion
JO - American Journal of Health Promotion
JA - Am J Health Promot
Y1 - 2006/01//Jan-Feb, 2006
VL - 20
IS - 3
SP - 214
EP - 222
CY - US
PB - American Journal of Health Promotion
SN - 0890-1171
SN - 2168-6602
AD - Harris, Jeffrey R., Health Promotion Research Center, University of Washington School of Public Health and Community Medicine, Seattle, WA, US, 98105
N1 - Accession Number: 2006-00903-010. PMID: 16422142 Partial author list: First Author & Affiliation: Bondi, Maris Ann; Partnership for Prevention, Pittsburgh, PA, US. Other Publishers: Sage Publications. Release Date: 20060221. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Employee Benefits; Health Care Services; Prevention. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Methodology: Empirical Study; Quantitative Study. Page Count: 9. Issue Publication Date: Jan-Feb, 2006.
AB - Purpose: To characterize employers' coverage of clinical preventive services. Design: Mercer Human Resource Consulting Inc. included questions on clinical preventive services as part of its National Survey of Employer-Sponsored Health Plans, 2001. Setting: A national sample of employers of a large, medium, and small number of employees, including governments. Subjects: Respondents self-identified as most knowledgeable about the organization's health benefits. Measures: Weighted analyses of responses to eight survey questions on health promotion. Results: The survey was completed by 2180 employers, and the response rate was 21%. More than 90% of employers included increased productivity and decreased health care costs among their most important reasons for coverage of clinical preventive services. Within health insurance, coverage of physical examinations, immunizations, and screenings generally exceeded 50%, but coverage of lifestyle modification services was less than 20%. Only 20% of employers covered tobacco cessation services, and only 4% of employers provided an 'optimal' benefit. We compared employers' offerings with a published ranking, by impact and value, of clinical preventive services. We found the biggest discrepancy in tobacco cessation services and alcohol problem prevention, which ranked high in terms of impact and value but are offered by only 20% and 18% of employers, respectively. Conclusions: Employers seek financial return from their offerings of clinical preventive services to employees, but they are least likely to offer the services most likely to provide this return. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical preventive services
KW - employer coverage
KW - health benefits
KW - 2006
KW - Employee Benefits
KW - Health Care Services
KW - Prevention
KW - 2006
DO - 10.4278/0890-1171-20.3.214
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-00903-010&site=ehost-live&scope=site
UR - jh7@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04630-004
AN - 2006-04630-004
AU - Wysowski, Diane K.
AU - Governale, Laura A.
AU - Swann, Joslyn
T1 - Trends in outpatient prescription drug use and related costs in the us 1998-2003.
JF - PharmacoEconomics
JO - PharmacoEconomics
JA - Pharmacoeconomics
Y1 - 2006///
VL - 24
IS - 3
SP - 233
EP - 236
CY - New Zealand
PB - Adis International
SN - 1170-7690
SN - 1179-2027
AD - Wysowski, Diane K., Division of Drug Risk Evaluation, Food and Drug Administration, HFD-430, White Oak Campus, Bldg. 22, Rm 3424, 10903 New Hampshire Ave, Silver Spring, MD, US, 20993
N1 - Accession Number: 2006-04630-004. PMID: 16519545 Partial author list: First Author & Affiliation: Wysowski, Diane K.; Division of Drug Risk Evaluation, Food and Drug Administration, Rockville, MD, US. Other Publishers: Springer. Release Date: 20061002. Correction Date: 20120806. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Outpatients; Prescription Drugs; Trends. Classification: Outpatient Services (3371). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: National Disease and Therapeutic Index. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: 2006.
AB - Objective: To present a brief synopsis of trends in the number of prescriptions and retail costs of outpatient drugs dispensed in the US between 1998 and 2003. Methods: Data were extracted from IMS Health, the National Prescription Audit Plus™ and the National Disease and Therapeutic Index™ databases. Results: In 1998, 2.7 billion outpatient prescriptions were dispensed versus 3.6 billion in 2003. This equates to a 33.3% increase over the 6-year period. Of the top 20 most dispensed drugs by volume, 40% were launched in the 1990s or 2000s. Retail costs for the total market of dispensed outpatient prescription drugs were $US96.1 billion in 1998 and $US196 billion in 2003, a 104% increase. Of the top 20 most dispensed drugs by retail cost, all were tradename drugs and were launched in the 1990s or 2000s. Conclusions: These data indicate a large increase in the US over a short time period in dispensed outpatient prescriptions and their associated retail costs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trends
KW - outpatient prescription drug use
KW - retail costs
KW - US
KW - 2006
KW - Costs and Cost Analysis
KW - Outpatients
KW - Prescription Drugs
KW - Trends
KW - 2006
DO - 10.2165/00019053-200624030-00003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04630-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12721-004
AN - 2006-12721-004
AU - Razzano, Lisa A.
AU - Hamilton, Marie M.
AU - Perloff, Judith K.
T1 - Work status, benefits, and financial resources among people with HIV/AIDS.
T3 - HIV/AIDS and employment: the continuing challenge
JF - Work: Journal of Prevention, Assessment & Rehabilitation
JO - Work: Journal of Prevention, Assessment & Rehabilitation
JA - Work
Y1 - 2006///
VL - 27
IS - 3
SP - 235
EP - 245
CY - Netherlands
PB - IOS Press
SN - 1051-9815
SN - 1875-9270
AD - Razzano, Lisa A., Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, M/C 913, Chicago, IL, US, 60612
N1 - Accession Number: 2006-12721-004. PMID: 17006000 Partial author list: First Author & Affiliation: Razzano, Lisa A.; Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20061211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Employment Status; Health Insurance; HIV. Minor Descriptor: Economics; Occupational Aspirations; Treatment. Classification: Immunological Disorders (3291); Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: 2006.
AB - With the advent of more advanced treatments and therapies, people with HIV/AIDS are experiencing significant improvements in their health, making many of their ongoing employment and career goals more realistic. However, people with HIV/AIDS continue to have major concerns regarding the impact of working on their benefits and entitlements, including apprehensions about potential economic hardships related to loss of financial supports and health insurance coverage. This article focuses on factors related to employment status, sources of health benefits, and entitlements among people with HIV/AIDS. In addition, results of the study demonstrate differences in employment status, benefit types, and the amount of financial support individuals receive based on gender. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work status
KW - financial resources
KW - HIV
KW - AIDS
KW - advanced treatments
KW - health insurance
KW - career goals
KW - economic hardships
KW - 2006
KW - AIDS
KW - Employment Status
KW - Health Insurance
KW - HIV
KW - Economics
KW - Occupational Aspirations
KW - Treatment
KW - 2006
U1 - Sponsor: Field-Initiated Research. Grant: H133G010093. Recipients: No recipient indicated
U1 - Sponsor: US Department of Education, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Disability & Rehabilitation Research. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12721-004&site=ehost-live&scope=site
UR - Razzano@psych.uic.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00236-008
AN - 2007-00236-008
AU - Puryear, Michele
AU - Weissman, Gloria
AU - Watson, Michael
AU - Mann, Marie
AU - Strickland, Bonnie
AU - van Dyck, Peter C.
T1 - The regional genetic and newborn screening service collaboratives: The first two years.
JF - Mental Retardation and Developmental Disabilities Research Reviews
JO - Mental Retardation and Developmental Disabilities Research Reviews
JA - Ment Retard Dev Disabil Res Rev
Y1 - 2006///
VL - 12
IS - 4
SP - 288
EP - 292
CY - US
PB - John Wiley & Sons
SN - 1080-4013
SN - 1098-2779
AD - Puryear, Michele, 5600 Fishers Lane, Room 18A-1, Rockville, MD, US, 20857
N1 - Accession Number: 2007-00236-008. PMID: 17183578 Other Journal Title: Developmental Disabilities Research Reviews. Partial author list: First Author & Affiliation: Puryear, Michele; Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD, US. Release Date: 20070430. Correction Date: 20081208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cooperation; Genetics; Health Care Services; Health Screening; Technology. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120). References Available: Y. Page Count: 5. Issue Publication Date: 2006.
AB - Newborn screening and genetic technologies are expanding and changing rapidly, increasing the demand for genetic specialty services. Because of the scarcity and geographic maldistribution of genetic specialty services, access to these services is a critical issue. This article discusses some of the efforts initiated by the Maternal and Child Health Bureau of the Health Resources and Services Administration, particularly the establishment of regional genetic and newborn screening collaboratives to improve access to these services and expertise. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genetic and& newborn screening
KW - service collaboratives
KW - health care services
KW - 2006
KW - Cooperation
KW - Genetics
KW - Health Care Services
KW - Health Screening
KW - Technology
KW - 2006
DO - 10.1002/mrdd.20121
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00236-008&site=ehost-live&scope=site
UR - mpuryear@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19205-006
AN - 2009-19205-006
AU - Lester, Carolyn
AU - Allan, Alexandra
T1 - Teenage sexual health needs: Asking the consumers.
JF - Health Education
JO - Health Education
JA - Health Educ (Lond)
Y1 - 2006///
VL - 106
IS - 4
SP - 315
EP - 328
CY - United Kingdom
PB - Emerald Group Publishing Limited
SN - 0965-4283
SN - 1758-714X
AD - Lester, Carolyn
N1 - Accession Number: 2009-19205-006. Partial author list: First Author & Affiliation: Lester, Carolyn; National Public Health Service for Wales, Cathays Park, United Kingdom. Release Date: 20100531. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Health Education; Mental Health Programs; Sex Education; Sex Role Attitudes. Minor Descriptor: Health Service Needs; Sexually Transmitted Diseases. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2006. Copyright Statement: Emerald Group Publishing Limited
AB - Purpose: In response to rising prevalence of sexually transmitted infection (STI) among teenagers, this study was designed to examine teenage perceptions of sex education, access to services, and attitudes relevant to STI. Design/methodology/approach: A focus group study was conducted in three schools to discuss the sexual health needs of teenagers. Four single sex groups of 14-15 year olds (two male and two female) comprising six to nine participants met for two one-hour sessions. Interviews were recorded, transcribed and analysed by two researchers. Findings: Sex education was reported to vary considerably in quality and content both between and within schools. Participants felt that this was due to some teachers being embarrassed, resulting in didactic delivery and lack of discussion. Most participants had received very little information about STI, including how it could be avoided or what to do if infection was suspected. Many felt that it would be useful to have an organised visit to a sexual health/contraceptive clinic as part of the curriculum and that it would also be helpful if clinic staff contributed to their sex education. Research limitations/implications: Teachers selected participants based on their maturity and willingness to take part, which may have resulted in failure to include those in greatest need of sexual health services. Practical implications: Teenagers need more comprehensive sex education at an earlier age, delivered by individuals who are expert in the subject and comfortable in its delivery. Information alone is not enough but should be linked to accessible user-friendly services for contraception and general sexual health. Originality/value: This paper provides information on teenage sexual health needs in general and to the field of STI in particular. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent perceptions
KW - teenager attitudes
KW - sexually transmitted infection
KW - STI
KW - STD
KW - sex education
KW - access to services
KW - sexual health needs
KW - 2006
KW - Adolescent Attitudes
KW - Health Education
KW - Mental Health Programs
KW - Sex Education
KW - Sex Role Attitudes
KW - Health Service Needs
KW - Sexually Transmitted Diseases
KW - 2006
DO - 10.1108/09654280610673490
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19205-006&site=ehost-live&scope=site
UR - carolyn.lester@nphs.wales.nhs.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-11432-012
AN - 2006-11432-012
AU - Lidz, Charles W.
T1 - The Therapeutic Misconception and Our Models of Competency and Informed Consent.
JF - Behavioral Sciences & the Law
JO - Behavioral Sciences & the Law
JA - Behav Sci Law
Y1 - 2006///
VL - 24
IS - 4
SP - 535
EP - 546
CY - US
PB - John Wiley & Sons
SN - 0735-3936
SN - 1099-0798
AD - Lidz, Charles W., Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-11432-012. PMID: 16883621 Partial author list: First Author & Affiliation: Lidz, Charles W.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060911. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bioethics; Competence; Decision Making; Informed Consent; Professional Standards. Minor Descriptor: Therapeutic Processes. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: 2006.
AB - The doctrine of informed consent rests on empirical claims. This is true particularly of what commentators have characterized as the 'strong' model of informed consent. This model assumes that if adequate information is given to a competent individual, understanding will result and, permitted to make a voluntary decision, the individual will make a rational decision. However, the 'therapeutic misconception' posits that individuals may confuse the goals of research with those of treatment and may make decisions that do not rest on adequate understanding. This article reviews research suggesting that this may in fact be true, and concludes that, as a result, traditional notions of informed consent may not yield results consistent with the assumptions on which the doctrine of informed consent rests. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - therapeutic misconception
KW - competency
KW - informed consent
KW - voluntary decision making
KW - 2006
KW - Bioethics
KW - Competence
KW - Decision Making
KW - Informed Consent
KW - Professional Standards
KW - Therapeutic Processes
KW - 2006
U1 - Sponsor: National Institute of Mental Health. Grant: 1 R01-MH57685; 1 R01-MH57685. Recipients: No recipient indicated
DO - 10.1002/bsl.700
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11432-012&site=ehost-live&scope=site
UR - chuck.lidz@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23625-028
AN - 2006-23625-028
AU - Takahashi, Masaya
AU - Nakata, Akinori
AU - Haratani, Takashi
AU - Otsuka, Yasumasa
AU - Kaida, Kosuke
AU - Fukasawa, Kenji
T1 - Psychosocial work characteristics predicting daytime sleepiness in day and shift workers.
JF - Chronobiology International
JO - Chronobiology International
JA - Chronobiol Int
Y1 - 2006///
VL - 23
IS - 6
SP - 1409
EP - 1422
CY - United Kingdom
PB - Taylor & Francis
SN - 0742-0528
SN - 1525-6073
AD - Takahashi, Masaya, National Institute of Occupational Safety and Health, 6-21-1, Nagao, Tama-ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2006-23625-028. PMID: 17190723 Partial author list: First Author & Affiliation: Takahashi, Masaya; National Institute of Occupational Safety and Health, Kawasaki, Japan. Other Publishers: Informa Healthcare. Release Date: 20070122. Correction Date: 20160616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Job Satisfaction; Psychosocial Factors; Sleep Onset; Workday Shifts; Working Conditions. Minor Descriptor: Employee Attitudes; Occupational Safety; Occupational Stress; Work Load. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: U.S. National Institute for Occupational Safety and Health Generic Job Stress Questionnaire; Center for Epidemiologic Studies Depression Scale; Epworth Sleepiness Scale DOI: 10.1037/t07081-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: 2006.
AB - Characteristics of work organization other than working time arrangements may contribute importantly to daytime sleepiness. The present study was designed to identify the psychosocial factors at work that predict daytime sleepiness in a sample of day and shift workers. Participants working at a pulp and chemical factory completed an annual questionnaire regarding psychosocial factors at work using the U.S. National Institute for Occupational Safety and Health Generic Job Stress Questionnaire (i.e., quantitative workload, variance in workload, job control, support from supervisor, coworkers, or family/friends, job satisfaction, and depressive symptoms), as well as daytime sleepiness (through the Epworth Sleepiness Scale [ESS]) and sleep disturbances for three years starting in 2002 (response rates, 94.6-99.0%). The present analysis included 55 day workers (11 women) and 57 shift workers (all men) who participated in all three years of the study, worked under the same work schedule throughout the study period, and had no missing data on any of the daytime sleep items. A repeated-measures analysis of covariance (ANCOVA) was used to test the effects of work schedule (day vs. shift work) and psychosocial factors at work in 2002 on the ESS scores in subsequent years, with sleep duration, insomnia symptoms, chronic diseases, and sleepiness levels at baseline as covariates. Given significant and near-significant interactions of work schedules with psychosocial factor or study year, the ANCOVA, with the factors of psychosocial work characteristics and study year, was performed by type of work schedule. The results indicated a significant main effect of psychosocial work characteristics (p=0.010, partial η² = 0.14) and an almost significant main effect of study year (p-0.067, partial η² = 0.06) and interaction between psychosocial work characteristics and study year (p=0.085, partial η² = 0.06) for variance in workload among the day work group. The day workers reporting high variance in workload in 2002 exhibited significantly higher ESS scores in 2003 and 2004 than did those reporting low variance in workload. The ANCOVA for the shift work group showed a main effect of psychosocial work characteristics for job satisfaction (p=0.026, partial η² = 0.10) and depressive symptoms (p=0.094, partial η² = 0.06) with the interaction between psychosocial work characteristics and study year for job satisfaction (p=0.172, partial η² = 0.04) and depressive symptoms (p=0.035, partial η² = 0.07). The shift workers with low job satisfaction and high symptoms of depression in 2002 showed significantly greater ESS scores in 2003 and/or 2004 than did those with opposite characteristics. These results may suggest a potential predictive value of variance in workload for day workers as well as job satisfaction and depressive symptoms for shift workers with respect to daytime sleepiness. The present findings may imply that redesigning these aspects of work environment would be of help in managing daytime sleepiness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial work characteristics
KW - daytime sleepiness
KW - shift workers
KW - work environment
KW - occupational safety
KW - job satisfaction
KW - work load
KW - job stress
KW - 2006
KW - Job Satisfaction
KW - Psychosocial Factors
KW - Sleep Onset
KW - Workday Shifts
KW - Working Conditions
KW - Employee Attitudes
KW - Occupational Safety
KW - Occupational Stress
KW - Work Load
KW - 2006
U1 - Sponsor: Ministry of Education, Culture, Sports, Science and Technology, Japan. Grant: 160790332. Other Details: Grant-in-Aid for Scientific Research. Recipients: No recipient indicated
DO - 10.1080/07420520601100963
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23625-028&site=ehost-live&scope=site
UR - takaham@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2006-03455-000
AN - 2006-03455-000
AU - Feerick, Margaret M.
AU - Silverman, Gerald B.
ED - Feerick, Margaret M.
ED - Silverman, Gerald B.
T1 - Children exposed to violence.
Y1 - 2006///
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-804-3
SN - 978-155766-804-2
N1 - Accession Number: 2006-03455-000. Partial author list: First Author & Affiliation: Feerick, Margaret M.; Feerick Counsulting, Laytonsville, MD, US. Release Date: 20060522. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 1-55766-804-3, Paperback; 978-155766-804-2, Paperback. Language: English. Major Descriptor: Adolescent Development; Childhood Development; Intervention; Violence. Minor Descriptor: Academic Achievement; Communities; Domestic Violence; Health; Psychosocial Development; Terrorism; War; Well Being. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Page Count: 267.
AB - This book answers critical questions about children exposed to violence, such as (1) What do we know about the effects of children's exposure to violence? (2) What are the best interventions? and (3) What kind of research still needs to be done? The authors bring readers closer to solving one of today's most prominent social problems. Focusing on domestic violence, community violence, and war and terrorism in the lives of children from birth to age 17, two dozen foremost authorities synthesize current knowledge and present the comprehensive, focused research agenda we need to work toward solutions. Readers will understand how exposure to violence affects physical health, psychological well-being, social development, and academic achievement, get up-to-date statistics on violence and research on prevalence, pinpoint the gaps in our current knowledge, learn from promising interventions, review existing and emerging public policies, and examine recommendations for future research in support of best practices Required reading for psychologists, educators, social workers, researchers, policymakers, and all others who work with children exposed to violence, this eye-opening book gives readers the insight they need to work toward violence prevention and develop evidence-based interventions for children and families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children
KW - violence
KW - violence effects
KW - interventions
KW - domestic violence
KW - community violence
KW - war
KW - terrorism
KW - health
KW - well-being
KW - social development
KW - academic achievement
KW - 2006
KW - Adolescent Development
KW - Childhood Development
KW - Intervention
KW - Violence
KW - Academic Achievement
KW - Communities
KW - Domestic Violence
KW - Health
KW - Psychosocial Development
KW - Terrorism
KW - War
KW - Well Being
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03455-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2009-01038-000
AN - 2009-01038-000
AU - Feerick, Margaret M.
AU - Knutson, John F.
AU - Trickett, Penelope K.
AU - Flanzer, Sally M.
ED - Feerick, Margaret M.
ED - Knutson, John F.
ED - Trickett, Penelope K.
ED - Flanzer, Sally M.
T1 - Child abuse and neglect: Definitions, classifications, and a framework for research.
Y1 - 2006///
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-759-4
SN - 978-1-55766-759-5
N1 - Accession Number: 2009-01038-000. Partial author list: First Author & Affiliation: Feerick, Margaret M.; Feerick Consulting, Laytonsville, MD, US. Release Date: 20090706. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 1-55766-759-4, Paperback; 978-1-55766-759-5, Paperback. Language: English. Major Descriptor: Child Abuse; Child Neglect. Minor Descriptor: Experimentation; Taxonomies; Terminology. Classification: Criminal Behavior & Juvenile Delinquency (3236). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 404.
AB - This landmark book is the first to offer perspectives on developing a precise, scientifically valid system of defining, classifying, and measuring child maltreatment. Directly addressing the biggest barriers to research—lack of consistent definitions and measurement approaches—this volume presents a framework for conducting successful research, giving readers the information they need to clarify the limitations of current definitions, classification systems, and measurement approaches; revise the research definitions for four types of abuse: physical abuse, sexual abuse, psychological maltreatment, and neglect; use multimethod, multisource approaches to classification and measurement; understand how social policy trends help or hinder both research and practice; and, address the ethical challenges of conducting research with vulnerable children and families The result of two federally funded workshops pooling the knowledge of two dozen experts, this indispensable volume will help researchers and policy makers reach consensus on how to define and measure child maltreatment—and facilitate the research that will lead to better prevention and treatment efforts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child abuse & neglect
KW - definitions
KW - classifications
KW - research
KW - 2006
KW - Child Abuse
KW - Child Neglect
KW - Experimentation
KW - Taxonomies
KW - Terminology
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01038-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2006-03272-000
AN - 2006-03272-000
AU - Kelloway, E. Kevin
AU - Barling, Julian
AU - Hurrell, Joseph J. Jr.
T1 - Handbook of workplace violence.
Y1 - 2006///
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 0-7619-3062-0
N1 - Accession Number: 2006-03272-000. Partial author list: First Author & Affiliation: Kelloway, E. Kevin; Saint Mary's University, Halifax, NS, Canada. Release Date: 20060724. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Handbook/Manual. ISBN: 0-7619-3062-0, Hardcover. Language: English. Major Descriptor: Violence; Working Conditions; Workplace Violence. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 696.
AB - In the Handbook of Workplace Violence, editors E. Kevin Kelloway, Julian Barling, and Joseph J. Hurrell Jr. bring together the contributions of leading researchers to provide summaries and unique perspectives on current theory, research, and practice relating to workplace violence. This is the most up-to-date resource available providing a comprehensive overview of the current state of knowledge regarding all aspects of workplace violence and aggression. Part I summarizes the leading theoretical perspectives on violence and aggression and provides prevalence estimates for aggression and violence in North American workplaces. Part II focuses on leading experts in the field summarizing what is known about the sources of workplace violence (e.g., partner violence, communal violence, industrial relations violence, public-initiated violence), forms of aggression in the workplace (e.g., emotional abuse, workplace bullying, cyber-aggression), and populations (e.g., occupations, youth) at special risk for workplace violence and aggression. Part III considers the experience of victims as well as individual (e.g., critical incident stress debriefing) and organizational (e.g., selection, training) interventions designed to prevent or ameliorate the consequences of workplace violence. This is a valuable resource for researchers and practitioners in the fields of Industrial and Organizational Psychology, Human Resources, Health Psychology, Public Health, and Employee Assistance Programs. It is also an excellent textbook for graduate courses in Organizational Behavior, Occupational Health Psychology, and Organizational Psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace violence
KW - 2006
KW - Violence
KW - Working Conditions
KW - Workplace Violence
KW - 2006
DO - 10.4135/9781412976947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03272-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Heller, David N.
AU - Smith, Michelle L.
AU - Chiesa, O. Alberto
T1 - LC/MS/MS measurement of penicillin G in bovine plasma, urine, and biopsy samples taken from kidneys of standing animals
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/01/02/
VL - 830
IS - 1
M3 - Article
SP - 91
EP - 99
SN - 15700232
AB - Abstract: Methods for the measurement of penicillin concentration in bovine plasma, kidney and urine were developed and validated. Detection was based on liquid chromatography/tandem mass spectrometry (LC/MS/MS). Phenethecillin was used as an internal standard. Plasma was extracted with acetonitrile using a method with a calculated limit of quantitation (LOQ) of 12ng/mL. Kidney samples were homogenized in water and acetonitrile, then cleaned up on C18-bonded silica SPE cartridges. The LOQ of this procedure was 10ng/g. Urine samples were diluted, filtered, and analyzed directly. The LOQ of this procedure was 63ng/mL. The overall accuracy for plasma was 103% with coefficient of variation (CV) of 3%; for kidney, 96% and 11%, respectively, and for urine, 98% and 4%, respectively. These methods were applied to the analysis of plasma, urine, and kidney biopsy samples taken from standing animals that had been dosed with penicillin. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PENICILLIN
KW - ANTIBACTERIAL agents
KW - CHROMATOGRAPHIC analysis
KW - LIQUID chromatography
KW - MASS spectrometry
KW - ACETONITRILE
KW - Kidney
KW - Liquid chromatography–tandem mass spectrometry
KW - Penicillin
KW - Plasma
KW - Quantification
KW - Residue analysis
KW - Urine
N1 - Accession Number: 19306520; Heller, David N.; Email Address: david.heller@fda.gov Smith, Michelle L. 1 Chiesa, O. Alberto 1; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD, USA; Source Info: Jan2006, Vol. 830 Issue 1, p91; Subject Term: PENICILLIN; Subject Term: ANTIBACTERIAL agents; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: ACETONITRILE; Author-Supplied Keyword: Kidney; Author-Supplied Keyword: Liquid chromatography–tandem mass spectrometry; Author-Supplied Keyword: Penicillin; Author-Supplied Keyword: Plasma; Author-Supplied Keyword: Quantification; Author-Supplied Keyword: Residue analysis; Author-Supplied Keyword: Urine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jchromb.2005.10.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19306520&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106398197
T1 - From the field... Building a strong foundation: the Substance Abuse and Mental Health Services Administration.
AU - Curie CG
Y1 - 2006/01/02/
N1 - Accession Number: 106398197. Language: English. Entry Date: 20060217. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9885868.
KW - Mental Health Services -- Administration
KW - Substance Abuse and Mental Health Services Administration
KW - Substance Use Disorders -- Rehabilitation
KW - United States
SP - 5
EP - 6
JO - Mental Health Weekly
JF - Mental Health Weekly
JA - MENT HEALTH WKLY
VL - 16
IS - 1
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
SN - 1058-1103
AD - Administrator of the Substance Abuse and Mental Health Services Administration (SAMHSA), US Department of Health and Human Services
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106398197&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stiles, C. H. Wardell
AU - Altman, W. L.
T1 - HOOKWORM DISEASE.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 59
EP - 69
SN - 00333549
AB - Discusses the results of a study on the presence of Necator americanus and Ancylostoma duodenale in hookworm infection and its treatment conducted in the U.S. Number of male and female hookworms discovered in cases of Ancylostoma duodenale; Effect of thymol treatment on hookworm infection; Factor to consider in determining the frequency of the treatment.
KW - HOOKWORM disease
KW - NECATOR americanus
KW - ANCYLOSTOMA duodenale
KW - HOOKWORMS
KW - THYMOL
KW - UNITED States
N1 - Accession Number: 20358323; Stiles, C. H. Wardell 1 Altman, W. L. 2; Affiliation: 1: Professor of Zoology, Hygienic Laboratory, United States Public Health Service 2: Assistant, Hygienic Laboratory, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p59; Subject Term: HOOKWORM disease; Subject Term: NECATOR americanus; Subject Term: ANCYLOSTOMA duodenale; Subject Term: HOOKWORMS; Subject Term: THYMOL; Subject Term: UNITED States; Number of Pages: 11p; Illustrations: 14 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358323&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldberger, Joseph
T1 - THE ETIOLOGY OF PELLAGRA.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 77
EP - 79
SN - 00333549
AB - Analyzes the etiology of pellagra as a communicable disease. Immunity of medical personnel to the disease at the South Carolina State Hospital; Difference in the diet of patients and personnel in the hospital; Epidemiological features of the disease; Influence of corn or corn products in the production of pellagra.
KW - PELLAGRA
KW - DISEASES -- Causes & theories of causation
KW - MEDICAL personnel -- Health
KW - STATE hospitals
KW - DIET
KW - EPIDEMIOLOGY
KW - CORN
KW - SOUTH Carolina
N1 - Accession Number: 20358327; Goldberger, Joseph 1; Affiliation: 1: Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p77; Subject Term: PELLAGRA; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: MEDICAL personnel -- Health; Subject Term: STATE hospitals; Subject Term: DIET; Subject Term: EPIDEMIOLOGY; Subject Term: CORN; Subject Term: SOUTH Carolina; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358327&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carter, H. R.
T1 - QUININE PROPHYLAXIS FOR MALARIA.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 81
EP - 85
SN - 00333549
AB - Discusses the advantages of using quinine to prevent and treat malaria. Factors to consider in determining whether to utilize quinine; Decline in the number of occurrences of malarial fever and deaths from the disease in Italy in 1914 following the implementation of the systematic use of the bark by the government; Capability of quinine to prevent people from communicating the disease to others.
KW - QUININE
KW - MALARIA -- Prevention
KW - MORTALITY -- Statistics
KW - COMMUNICABLE diseases -- Transmission
KW - THERAPEUTIC use
KW - ITALY
N1 - Accession Number: 20358329; Carter, H. R. 1; Affiliation: 1: Senior Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p81; Subject Term: QUININE; Subject Term: MALARIA -- Prevention; Subject Term: MORTALITY -- Statistics; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: THERAPEUTIC use; Subject Term: ITALY; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358329&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, John F.
T1 - TYPHUS FEVER.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 87
EP - 90
SN - 00333549
AB - Examines the etiology and methods of prevention of typhus fever. Resistance of the virus in the blood to heating and freezing; Differences in the eruption of typhus and typhoid; Measures included in the reduction of lice infestation among the population.
KW - TYPHUS fever
KW - DISEASES -- Causes & theories of causation
KW - PREVENTIVE medicine
KW - TYPHOID fever
KW - VIRUSES
KW - PEDICULOSIS
N1 - Accession Number: 20358331; Anderson, John F. 1; Affiliation: 1: Director, Hygienic Laboratory, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p87; Subject Term: TYPHUS fever; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: PREVENTIVE medicine; Subject Term: TYPHOID fever; Subject Term: VIRUSES; Subject Term: PEDICULOSIS; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358331&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mullan, E. H.
T1 - MENTAL EXAMINATION OF IMMIGRANTS ADMINISTRATION AND LINE INSPECTION AT ELLIS ISLAND.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 93
EP - 103
SN - 00333549
AB - Assesses the mental examination of immigrants brought to Ellis Island in New York conducted by the U.S. Public Health Service. Functions of medical officers stationed in the inspection lines; Standard operating procedures in examining the physical condition of immigrants; Signs and symptoms in immigrants that might suggest an active or maniacal psychosis; Purpose of the weeding-out process.
KW - MENTAL status examination
KW - IMMIGRANTS -- United States
KW - IMMIGRANTS
KW - PSYCHOSES
KW - MEDICAL examinations
KW - ELLIS Island (N.J. & N.Y.)
KW - NEW York (State)
KW - UNITED States. Public Health Service
N1 - Accession Number: 20358333; Mullan, E. H. 1; Affiliation: 1: Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p93; Subject Term: MENTAL status examination; Subject Term: IMMIGRANTS -- United States; Subject Term: IMMIGRANTS; Subject Term: PSYCHOSES; Subject Term: MEDICAL examinations; Subject Term: ELLIS Island (N.J. & N.Y.); Subject Term: NEW York (State); Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358333&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warren, B. S.
AU - Sydenstricker, Edgar
T1 - HEALTH INSURANCE, THE MEDICAL PROFESSION, AND THE PUBLIC HEALTH.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 107
EP - 114
SN - 00333549
AB - Discusses the benefits of the legislative proposals for governmental health insurance in the U.S. in 1919. Definition of sickness insurance; Inclusion of an adequate medical service for the insured in the proposals; Necessity for accurate morbidity statistics as demonstrated by the wide discrepancy in estimates.
KW - HEALTH insurance -- Law & legislation
KW - HEALTH insurance -- United States
KW - MEDICAL care -- United States
KW - MORTALITY -- Statistics
KW - UNITED States
N1 - Accession Number: 20358337; Warren, B. S. 1 Sydenstricker, Edgar 2; Affiliation: 1: Assistant Surgeon General, United States Public Health Service 2: Public Health Statistician, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p107; Subject Term: HEALTH insurance -- Law & legislation; Subject Term: HEALTH insurance -- United States; Subject Term: MEDICAL care -- United States; Subject Term: MORTALITY -- Statistics; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20358337&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warren, Benjamin S.
AU - Bolduan, Charles F.
T1 - WAR ACTIVITIES OF THE UNITED STATES PUBLIC HEALTH SERVICE.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 117
EP - 131
SN - 00333549
AB - Examines the contributions of the U.S. Public Health Service during World War I. Extra-cantonment where the agency carried on health supervision and where the sanitary units of the American Red Cross operated; Operations included in the general sanitation activity; Plants inspected by the Public Health Service as to the hygienic conditions of the explosive industry.
KW - HISTORY
KW - WORLD War, 1914-1918
KW - AMERICAN military bases
KW - MILITARY personnel -- Medical care
KW - SANITATION
KW - FACTORY sanitation
KW - UNITED States
KW - UNITED States. Public Health Service
KW - AMERICAN Red Cross
N1 - Accession Number: 20358339; Warren, Benjamin S. 1 Bolduan, Charles F. 2; Affiliation: 1: Assistant Surgeon General, United States Public Health Service 2: Chief, Section of Public Health Education, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p117; Subject Term: HISTORY; Subject Term: WORLD War, 1914-1918; Subject Term: AMERICAN military bases; Subject Term: MILITARY personnel -- Medical care; Subject Term: SANITATION; Subject Term: FACTORY sanitation; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service Company/Entity: AMERICAN Red Cross; NAICS/Industry Codes: 928110 National Security; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lumsden, L. L.
T1 - THE PUBLIC HEALTH PROGRAM OF THE UNITED STATES TRAINING CORPS FOR WOMEN.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 133
EP - 135
SN - 00333549
AB - Provides information on the public health program of the U.S. armed forces training corps for women. Information on the training plan formulated by trainer Susanna Cocroft; Number of women who took the training course at the Camp Geneva in Lake Geneva, Wisconsin in 1919; Objective of the training course; Topics discussed at camp lectures.
KW - PHYSICAL fitness for women
KW - PUBLIC health -- United States
KW - ARMED Forces
KW - LECTURES & lecturing
KW - UNITED States
KW - LAKE Geneva (Wis.)
KW - WISCONSIN
KW - COCROFT, Susanna
N1 - Accession Number: 20358341; Lumsden, L. L. 1; Affiliation: 1: Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p133; Subject Term: PHYSICAL fitness for women; Subject Term: PUBLIC health -- United States; Subject Term: ARMED Forces; Subject Term: LECTURES & lecturing; Subject Term: UNITED States; Subject Term: LAKE Geneva (Wis.); Subject Term: WISCONSIN; NAICS/Industry Codes: 928110 National Security; People: COCROFT, Susanna; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warren, B. S.
T1 - COORDINATION AND EXPANSION OF FEDERAL HEALTH ACTIVITIES.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 137
EP - 147
SN - 00333549
AB - Discusses the coordination and expansion of the federal health services and activities in the U.S. Historical outline of the development of the Public Health Service; Advantages of the creation of a department of health; Viability of transferring federal health agencies to existing executive department under an assistant secretary for health.
KW - PUBLIC health -- United States
KW - GOVERNMENT agencies
KW - EXECUTIVE departments -- United States
KW - CABINET officers
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 20358343; Warren, B. S. 1; Affiliation: 1: Assistant Surgeon General, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p137; Subject Term: PUBLIC health -- United States; Subject Term: GOVERNMENT agencies; Subject Term: EXECUTIVE departments -- United States; Subject Term: CABINET officers; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 921110 Executive Offices; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frost, W. H.
T1 - THE EPIDEMIOLOGY OF INFLUENZA.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 149
EP - 159
SN - 00333549
AB - Discusses the epidemiology of influenza. Rates of influenza and pneumonia mortality in Massachusetts from 1887 to 1916; Results of the house to house surveys on influenza pandemic; Difference of influenza from other infections; General characteristics of epidemic.
KW - EPIDEMIOLOGY
KW - INFLUENZA
KW - MORTALITY
KW - COMMUNICABLE diseases -- Transmission
KW - UNITED States
N1 - Accession Number: 20358345; Frost, W. H. 1; Affiliation: 1: Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p149; Subject Term: EPIDEMIOLOGY; Subject Term: INFLUENZA; Subject Term: MORTALITY; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: UNITED States; Number of Pages: 11p; Illustrations: 4 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kolb, Lawrence
AU - Du Mez, A. G.
T1 - THE PREVALENCE AND TREND OF DRUG ADDICTION IN THE UNITED STATES AND FACTORS INFLUENCING IT.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 161
EP - 173
SN - 00333549
AB - Discusses the findings of a study on the prevalence of drug addiction in the U.S. and factors that influence it. Estimated number of addicts in the U.S. based on actual counts, narcotic surveys, reports from physicians and available supplies; Average amount of morphine or heroin that an addict consumes daily; Increase in the proportion of the delinquent type of addict.
KW - DRUG abuse
KW - DRUG addicts
KW - DRUGS of abuse
KW - MORPHINE
KW - HEROIN
KW - UNITED States
N1 - Accession Number: 20358347; Kolb, Lawrence 1 Du Mez, A. G. 2; Affiliation: 1: Surgeon, United States Public Health Service 2: Pharmacologist, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p161; Subject Term: DRUG abuse; Subject Term: DRUG addicts; Subject Term: DRUGS of abuse; Subject Term: MORPHINE; Subject Term: HEROIN; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 13p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frank, Leslie C.
T1 - A STATE-WIDE MILK SANITATION PROGRAM.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 175
EP - 189
SN - 00333549
AB - Discusses the milk sanitation program formulated and executed by the Alabama State Board of Health and the U.S. Public Health Service. Reasons behind the need for a state-wide sanitation program; Types of milk ordinance; Overview of the standard milk ordinance for Alabama municipalities.
KW - HEALTH promotion
KW - MILK hygiene
KW - DAIRY laws
KW - HEALTH boards
KW - PUBLIC health administration
KW - ALABAMA
KW - UNITED States. Public Health Service
N1 - Accession Number: 20358349; Frank, Leslie C. 1; Affiliation: 1: Associate Sanitary Engineer, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p175; Subject Term: HEALTH promotion; Subject Term: MILK hygiene; Subject Term: DAIRY laws; Subject Term: HEALTH boards; Subject Term: PUBLIC health administration; Subject Term: ALABAMA; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 15p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawrence, Arthur J.
T1 - COMMENTARY.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 190
EP - 190
SN - 00333549
AB - Expresses views on the article "The Incidence of Influenza Among Persons of Different Economic Status During the Epidemic of 1918," by Edgar Sydenstricker. Characteristics of the approach used by Sydenstricker in studying public health; Statement issued by Doctor Wade H. Frost regarding the scientific and evidence-based approach of Sydenstricker; Influence of Sydenstricker's article on social programs in the U.S.
KW - INFLUENZA Epidemic, 1918-1919
KW - PUBLIC health
KW - HEALTH education
KW - SOCIAL services
KW - UNITED States
KW - SYDENSTRICKER, Edgar
N1 - Accession Number: 20358350; Lawrence, Arthur J. 1; Affiliation: 1: Assistant Surgeon General and Deputy Assistant Secretary for Health (Operations), U.S. Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p190; Subject Term: INFLUENZA Epidemic, 1918-1919; Subject Term: PUBLIC health; Subject Term: HEALTH education; Subject Term: SOCIAL services; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 624190 Other Individual and Family Services; People: SYDENSTRICKER, Edgar; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sydenstricker, Edgar
T1 - THE INCIDENCE OF INFLUENZA AMONG PERSONS OF DIFFERENT ECONOMIC STATUS DURING THE EPIDEMIC OF 1918.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 191
EP - 204
SN - 00333549
AB - Discusses the link between the incidence of epidemic influenza in 1918 and the economic condition of the victims of the epidemic. Common illnesses recorded in cities in Maryland; Statistics on the incidence of epidemic influenza among white persons of different ages based on general economic condition of the households; Comparison of the influenza morbidity and case fatality rates at different ages among persons of different economic status in 1918.
KW - INFLUENZA Epidemic, 1918-1919
KW - EPIDEMICS
KW - ECONOMIC status
KW - INFLUENZA
KW - AGE factors in disease
KW - RESPIRATORY infections
KW - ECONOMIC aspects
N1 - Accession Number: 20358351; Sydenstricker, Edgar 1; Affiliation: 1: Statistician, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p191; Subject Term: INFLUENZA Epidemic, 1918-1919; Subject Term: EPIDEMICS; Subject Term: ECONOMIC status; Subject Term: INFLUENZA; Subject Term: AGE factors in disease; Subject Term: RESPIRATORY infections; Subject Term: ECONOMIC aspects; Number of Pages: 14p; Illustrations: 15 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bisgard, Kristine M.
T1 - COMMENTARY.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 206
EP - 206
SN - 00333549
AB - Comments on the article "Trends in Diphtheria Mortality," by Edward A. Lane, which discusses the high mortality rate from diphtheria in the U.S. in the pre-vaccine era. State which has the highest average annual mortality rate for diphtheria according to the report; Policies and changes in the care of diphtheria case-patients highlighted by Lane in his paper; Factor that contributed to the decline in the cases of diphtheria in 1940s.
KW - DIPHTHERIA
KW - MORTALITY
KW - VACCINATION
KW - MEDICAL policy
KW - MEDICAL laws & legislation
KW - UNITED States
KW - LANE, Edward
N1 - Accession Number: 20358352; Bisgard, Kristine M. 1; Affiliation: 1: Commander, U.S. Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p206; Subject Term: DIPHTHERIA; Subject Term: MORTALITY; Subject Term: VACCINATION; Subject Term: MEDICAL policy; Subject Term: MEDICAL laws & legislation; Subject Term: UNITED States; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: LANE, Edward; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trendley, H.
T1 - ENDEMIC FLUOROSIS AND ITS RELATION TO DENTAL CARIES.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 213
EP - 219
SN - 00333549
AB - Focuses on a study conducted by the U.S. Public Health Service to determine the toxicity of chronic endemic dental fluorosis. Total number of children with verified continuity of exposure who were examined in the study; Issues raised on the relationship of mottled enamel to dental caries; States in the country with high dental carries attack rates.
KW - DENTAL caries -- Research
KW - DENTAL caries in children
KW - FLUOROSIS
KW - MOTTLED enamel
KW - UNITED States. Public Health Service
N1 - Accession Number: 20358355; Trendley, H. 1; Affiliation: 1: Dental Surgeon, United States Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p213; Subject Term: DENTAL caries -- Research; Subject Term: DENTAL caries in children; Subject Term: FLUOROSIS; Subject Term: MOTTLED enamel; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 4 Charts, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Faget, G. H.
AU - Johansen, F. A.
AU - Ross, Hilary
T1 - SULFANILAMIDE IN THE TREATMENT OF LEPROSY.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 221
EP - 223
SN - 00333549
AB - Discusses the effectiveness of sulfanilamide in treating certain types of invasive bacterial diseases such as leprosy. Results of the preliminary laboratory procedures conducted among lepromatous patients; Toxic complications of sulfanilamide therapy in leprosy; Significance of the development of eosinophilia during the course of sulfanimide treatment.
KW - LEPROSY -- Treatment
KW - CLINICAL trials
KW - BACTERIAL diseases
KW - MYCOBACTERIAL diseases
KW - EOSINOPHILIA
KW - DRUGS -- Effectiveness
N1 - Accession Number: 20358357; Faget, G. H. 1 Johansen, F. A. 2 Ross, Hilary 3; Affiliation: 1: Surgeon, United States Public Health Service 2: Surgeon (R), United States Public Health Service 3: Medical Technician, United States Marine Hospital (National Leprosarium), Carville, Louisiana; Source Info: Jan2006 Supplement 1, Vol. 121, p221; Subject Term: LEPROSY -- Treatment; Subject Term: CLINICAL trials; Subject Term: BACTERIAL diseases; Subject Term: MYCOBACTERIAL diseases; Subject Term: EOSINOPHILIA; Subject Term: DRUGS -- Effectiveness; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moeller, Dade W.
AU - Terrill, James G.
AU - Ingraham, Samuel C.
T1 - RADIATION EXPOSURE IN THE UNITED STATES.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 225
EP - 233
SN - 00333549
AB - Discusses the impact of radiation exposure on public health. Average annual radiation exposure from medical diagnostic procedures per person in the U.S.; Other potential sources of X-ray exposure; Efforts of military and civilian agencies to expand the production and use of radioactive materials; Concerns raised by radiological health workers about such programs.
KW - RADIATION exposure
KW - MEDICAL radiology
KW - DIAGNOSTIC imaging
KW - X-rays
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 20358359; Moeller, Dade W. 1 Terrill, James G. 2 Ingraham, Samuel C. 3; Affiliation: 1: Sanitary engineer, environmental radiation specialist, Division of Engineering Resources, Bureau of State Services, Public Health Service 2: Chairman, Committee on Radiological Health of the Engineering Section, American Public Health Association 3: Assistant chief, Committee on Radiological Health of the Engineering Section, American Public Health Association; Source Info: Jan2006 Supplement 1, Vol. 121, p225; Subject Term: RADIATION exposure; Subject Term: MEDICAL radiology; Subject Term: DIAGNOSTIC imaging; Subject Term: X-rays; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Langmuir, Alexander D.
T1 - POLIOMYELITIS VACCINATION.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 243
EP - 245
SN - 00333549
AB - Presents an overview of a speech by Doctor Alexander D. Langmuir of the U.S. Public Health Service, delivered at the Departmental Council of the Department of Health, Education and Welfare on April 14, 1955. Discussion on the achievement of the new poliomyelitis vaccine; Major breakthroughs in the form of new discoveries and contributions to basic knowledge about poliomyelitis cited by Langmuir; Expectations of Langmuir on the acceptance of the vaccine.
KW - SPEECHES, addresses, etc.
KW - POLIOMYELITIS vaccine
KW - POLIO
KW - UNITED States
KW - UNITED States. Public Health Service
KW - LANGMUIR, Alexander
N1 - Accession Number: 20358363; Langmuir, Alexander D. 1; Affiliation: 1: Chief, Epidemiology Branch, Communicable Disease Center, Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p243; Subject Term: SPEECHES, addresses, etc.; Subject Term: POLIOMYELITIS vaccine; Subject Term: POLIO; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; People: LANGMUIR, Alexander; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Terry, Luther L.
T1 - HEALTH NEEDS OF THE NATION.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 253
EP - 257
SN - 00333549
AB - Discusses major health problems facing the U.S. Chronic illness and the aged; Provision of comprehensive health care; Environmental hazards with emphasis on water and air pollution and the use of new chemicals and ionizing radiation.
KW - PUBLIC health
KW - CHRONIC diseases
KW - OLDER people
KW - MEDICAL care
KW - HAZARDS
KW - UNITED States
N1 - Accession Number: 20358367; Terry, Luther L. 1; Affiliation: 1: Surgeon General, Public Health Service; Source Info: Jan2006 Supplement 1, Vol. 121, p253; Subject Term: PUBLIC health; Subject Term: CHRONIC diseases; Subject Term: OLDER people; Subject Term: MEDICAL care; Subject Term: HAZARDS; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koop, C. Everett
AU - Luoto, Joanne
T1 - "THE HEALTH CONSEQUENCES OF SMOKING: CANCER," OVERVIEW OF A REPORT OF THE SURGEON GENERAL.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/01/02/Jan2006 Supplement 1
VL - 121
M3 - Article
SP - 269
EP - 275
SN - 00333549
AB - Examines the link between smoking and various forms of cancer. Criteria necessary for judging the causal significance of data emanating from previous studies on the health consequences of smoking; Mortality ratios linking cigarette smoking with various types of cancers including lung, larynx and kidney; Effectiveness of self-help smoking cessation programs.
KW - SMOKING
KW - CANCER
KW - TOBACCO -- Physiological effect
KW - MORTALITY
KW - SMOKING cessation
N1 - Accession Number: 20358373; Koop, C. Everett 1 Luoto, Joanne 2; Affiliation: 1: Surgeon General, Public Health Service 2: Acting Director, Service's Office on Smoking and Health; Source Info: Jan2006 Supplement 1, Vol. 121, p269; Subject Term: SMOKING; Subject Term: CANCER; Subject Term: TOBACCO -- Physiological effect; Subject Term: MORTALITY; Subject Term: SMOKING cessation; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongmei Sun
AU - Hong Fang
AU - Tao Chen
AU - Perkins, Roger
AU - Tong, Weida
T1 - GOFFA: Gene Ontology For Functional Analysis -- A FDA Gene Ontology Tool for Analysis of Genomic and Proteomic Data.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - 1
EP - 11
PB - BioMed Central
SN - 14712105
AB - Background: Gene Ontology (GO) characterizes and categorizes the functions of genes and their products according to biological processes, molecular functions and cellular components, facilitating interpretation of data from high-throughput genomics and proteomics technologies. The most effective use of GO information is achieved when its rich and hierarchical complexity is retained and the information is distilled to the biological functions that are most germane to the phenomenon being investigated. Results: Here we present a FDA GO tool named Gene Ontology for Functional Analysis (GOFFA). GOFFA first ranks GO terms in the order of prevalence for a list of selected genes or proteins, and then it allows the user to interactively select GO terms according to their significance and specific biological complexity within the hierarchical structure. GOFFA provides five interactive functions (Tree view, Terms View, Genes View, GO Path and GO TreePrune) to analyze the GO data. Among the five functions, GO Path and GO TreePrune are unique. The GO Path simultaneously displays the ranks that order GOFFA Tree Paths based on statistical analysis. The GO TreePrune provides a visual display of a reduced GO term set based on a user's statistical cut-offs. Therefore, the GOFFA visual display can provide an intuitive depiction of the most likely relevant biological functions. Conclusion: With GOFFA, the user can dynamically interact with the GO data to interpret gene expression results in the context of biological plausibility, which can lead to new discoveries or identify new hypotheses. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - ONTOLOGY
KW - HEREDITY
KW - BREEDING
KW - PROTEINS
N1 - Accession Number: 28677551; Hongmei Sun 1; Email Address: hongmei.sun@fda.hhs.gov Hong Fang 1; Email Address: hong.fang@fda.hhs.gov Tao Chen 2; Email Address: tao.chen@fda.hhs.gov Perkins, Roger 1; Email Address: roger.perkins@fda.hhs.gov Tong, Weida 2; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: Z-tech Corporation, 3900 NCTR Road, Jefferson, Arkansas, 72079 USA 2: National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas, 72079 USA; Source Info: 2006 Supplement 2, Vol. 7, p1; Subject Term: GENES; Subject Term: ONTOLOGY; Subject Term: HEREDITY; Subject Term: BREEDING; Subject Term: PROTEINS; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S23
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lei Guo
AU - Hong Fang
AU - Collins, Jim
AU - Xiao-hui Fan
AU - Dial, Stacey
AU - Wong, Alex
AU - Mehta, Kshama
AU - Blann, Ernice
AU - Leming Shi
AU - Tong, Weida
AU - Dragan, Yvonne P.
T1 - Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712105
AB - Background: Fibrates are a unique hypolipidemic drugs that lower plasma triglyceride and cholesterol levels through their action as peroxisome proliferator-activated receptor alpha (PPARα) agonists. The activation of PPARα leads to a cascade of events that result in the pharmacological (hypolipidemic) and adverse (carcinogenic) effects in rodent liver. Results: To understand the molecular mechanisms responsible for the pleiotropic effects of PPARα agonists, we treated mouse primary hepatocytes with three PPARα agonists (bezafibrate, fenofibrate, and WY-14,643) at multiple concentrations (0, 10, 30, and 100 μM) for 24 hours. When primary hepatocytes were exposed to these agents, transactivation of PPARα was elevated as measured by luciferase assay. Global gene expression profiles in response to PPARα agonists were obtained by microarray analysis. Among differentially expressed genes (DEGs), there were 4, 8, and 21 genes commonly regulated by bezafibrate, fenofibrate, and WY-14,643 treatments across 3 doses, respectively, in a dose-dependent manner. Treatments with 100 μM of bezafibrate, fenofibrate, and WY-14,643 resulted in 151, 149, and 145 genes altered, respectively. Among them, 121 genes were commonly regulated by at least two drugs. Many genes are involved in fatty acid metabolism including oxidative reaction. Some of the gene changes were associated with production of reactive oxygen species, cell proliferation of peroxisomes, and hepatic disorders. In addition, 11 genes related to the development of liver cancer were observed. Conclusion: Our results suggest that treatment of PPARα agonists results in the production of oxidative stress and increased peroxisome proliferation, thus providing a better understanding of mechanisms underlying PPARα agonist-induced hepatic disorders and hepatocarcinomas. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - BLOOD plasma
KW - TRIGLYCERIDES
KW - CHOLESTEROL
KW - PEROXISOMES
KW - RODENTS
KW - RESEARCH
KW - RODENTS -- Diseases
N1 - Accession Number: 28677545; Lei Guo 1; Email Address: lei.guo@fda.hhs.gov Hong Fang 2; Email Address: hong.fang@fda.hhs.gov Collins, Jim 3; Email Address: jim_collins@agilent.com Xiao-hui Fan 1; Email Address: xiaohui.fan@fda.hhs.gov Dial, Stacey 1; Email Address: stacey.dial@fda.hhs.gov Wong, Alex 3; Email Address: alex_wong@agilent.com Mehta, Kshama 3; Email Address: kshama_mehta@agilent.com Blann, Ernice 1; Email Address: ernice.blann@fda.hhs.gov Leming Shi 1; Email Address: leming.shi@fda.hhs.gov; Tong, Weida 1; Email Address: weida.tong@fda.hhs.gov Dragan, Yvonne P. 1; Email Address: yvonne.dragan@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA 2: Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Agilent Technologies, Inc., Santa Clara, CA 95051, USA; Source Info: 2006 Supplement 2, Vol. 7, p1; Subject Term: DRUGS; Subject Term: BLOOD plasma; Subject Term: TRIGLYCERIDES; Subject Term: CHOLESTEROL; Subject Term: PEROXISOMES; Subject Term: RODENTS; Subject Term: RESEARCH; Subject Term: RODENTS -- Diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 12p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S18
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nan Mei
AU - Lei Guo
AU - Lu Zhang
AU - Leming Shi
AU - Sun, Yongming Andrew
AU - Fung, Chris
AU - Moland, Carrie L.
AU - Dial, Stacey L.
AU - Fuscoe, James C.
AU - Tao Chen
T1 - Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale).
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - 1
EP - 15
PB - BioMed Central
SN - 14712105
AB - Background: Comfrey is consumed by humans as a vegetable and a tea, and has been used as an herbal medicine for more than 2000 years. Comfrey, however, is hepatotoxic in livestock and humans and carcinogenic in experimental animals. Our previous study suggested that comfrey induces liver tumors by a genotoxic mechanism and that the pyrrolizidine alkaloids in the plant are responsible for mutation induction and tumor initiation in rat liver. Results: In this study, we identified comfrey-induced gene expression profile in the livers of rats. Groups of 6 male transgenic Big Blue rats were fed a basal diet and a diet containing 8% comfrey roots, a dose that resulted in liver tumors in a previous carcinogenicity bioassay. The animals were treated for 12 weeks and sacrificed one day after the final treatment. We used a rat microarray containing 26,857 genes to perform genome-wide gene expression studies. Dietary comfrey resulted in marked changes in liver gene expression, as well as in significant decreases in the body weight and increases in liver mutant frequency. When a two-fold cutoff value and a P-value less than 0.01 were selected, 2,726 genes were identified as differentially expressed in comfrey-fed rats compared to control animals. Among these genes, there were 1,617 genes associated by Ingenuity Pathway Analysis with particular functions, and the differentially expressed genes in comfrey-fed rat livers were involved in metabolism, injury of endothelial cells, and liver injury and abnormalities, including liver fibrosis and cancer development. Conclusion: The gene expression profile provides us a better understanding of underlying mechanisms for comfrey-induced hepatic toxicity. Integration of gene expression changes with known pathological changes can be used to formulate a mechanistic scheme for comfrey-induced liver toxicity and tumorigenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMFREY
KW - HERBAL medicine
KW - HEPATOTOXICOLOGY
KW - RATS
KW - RESEARCH
KW - CARCINOGENS
KW - MUTATION (Biology)
KW - GENES
N1 - Accession Number: 28677544; Nan Mei 1; Email Address: nan.mei@fda.hhs.gov Lei Guo 2; Email Address: lei.guo@fda.hhs.gov Lu Zhang 3,4; Email Address: lzhang@solexa.com Leming Shi 2; Email Address: leiming.shi@fda.hhs.gov Sun, Yongming Andrew 3; Email Address: sunya@appliedbiosystems.com Fung, Chris 3; Email Address: Chris.Fung@ucsf.edu; Moland, Carrie L. 2; Email Address: carrie.moland@fda.hhs.gov Dial, Stacey L. 2; Email Address: Stacey.dial@fda.hhs.gov Fuscoe, James C. 2; Email Address: james.fuscoe@fda.hhs.gov; Tao Chen 1; Email Address: tao.chen@fda.hhs.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: Molecular Biology-SDS/Arrays, Applied Biosystems, Foster City, CA 94404, USA 4: Solexa, Inc., 25861 Industrial Boulevard, Hayward, CA 94545, USA; Source Info: 2006 Supplement 2, Vol. 7, p1; Subject Term: COMFREY; Subject Term: HERBAL medicine; Subject Term: HEPATOTOXICOLOGY; Subject Term: RATS; Subject Term: RESEARCH; Subject Term: CARCINOGENS; Subject Term: MUTATION (Biology); Subject Term: GENES; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S16
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tao Han
AU - Jianyong Wang
AU - Tong, Weida
AU - Moore, Martha M.
AU - Fuscoe, James C.
AU - Tao Chen
T1 - Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712105
AB - Background: The Thymidine kinase (Tk) mutants generated from the widely used L5178Y mouse lymphoma assay fall into two categories, small colony and large colony. Cells from the large colonies grow at a normal rate while cells from the small colonies grow slowerthan normal. The relative proportion of large and small colonies after mutagen treatment is associated with a mutagen's ability to induce point mutations and/or chromosomal mutations. The molecular distinction between large and small colony mutants, however, is not clear. Results: To gain insights into the underlying mechanisms responsible for the mutant colony phenotype, microarray gene expression analysis was carried out on 4 small and 4 large colony Tk mutant samples. NCTR-fabricated long-oligonucleotide microarrays of 20,000 mouse genes were used in a two-color reference design experiment. The data were analyzed within ArrayTrack software that was developed at the NCTR. Principal component analysis and hierarchical clustering of the gene expression profiles showed that the samples were clearly separated into two groups based on their colony size phenotypes. The Welch T-test was used for determining significant changes in gene expression between the large and small colony groups and 90 genes whose expression was significantly altered were identified (p < 0.01; fold change > 1.5). Using Ingenuity Pathways Analysis (IPA), 50 out of the 90 significant genes were found in the IPA database and mapped to four networks associated with cell growth. Eleven percent of the 90 significant genes were located on chromosome 11 where the Tk gene resides while only 5.6% of the genes on the microarrays mapped to chromosome 11. All of the chromosome 11 significant genes were expressed at a higher level in the small colony mutants compared to the large colony mutants. Also, most of the significant genes located on chromosome 11 were disproportionally concentrated on the distal end of chromosome 11 where the Tk mutations occurred. Conclusion: The results indicate that microarray analysis can define cellular phenotypes and identify genes that are related to the colony size phenotypes. The findings suggest that genes in the DNA segment altered by the Tk mutations were significantly up-regulated in the small colony mutants, but not in the large colony mutants, leading to differential expression of a set of growth regulation genes that are related to cell apoptosis and other cellular functions related to the restriction of cell growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - THYMIDINE
KW - FOCAL adhesion kinase
KW - LYMPHOMAS
KW - CELLS
N1 - Accession Number: 28677558; Tao Han 1; Email Address: tao.han@fda.hhs.gov Jianyong Wang 2; Email Address: Jianyong.wang@fda.hhs.gov Tong, Weida 1; Email Address: weida.tong@fda.hhs.gov; Moore, Martha M. 1; Email Address: martha.moore@fda.hhs.gov Fuscoe, James C. 1; Email Address: james.fuscoe@fda.hhs.gov Tao Chen 1,2; Email Address: tao.chen@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, USA 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, USA; Source Info: 2006 Supplement 2, Vol. 7, p1; Subject Term: GENE expression; Subject Term: THYMIDINE; Subject Term: FOCAL adhesion kinase; Subject Term: LYMPHOMAS; Subject Term: CELLS; Number of Pages: 12p; Illustrations: 6 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delongchamp, Robert
AU - Taewon Lee
AU - Velasco, Cruz
T1 - A method for computing the overall statistical significance of a treatment effect among a group of genes.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - S11
EP - 9
PB - BioMed Central
SN - 14712105
AB - Background: In studies that use DNA arrays to assess changes in gene expression, our goal is to evaluate the statistical significance of treatments on sets of genes. Genes can be grouped by a molecular function, a biological process, or a cellular component, e.g., gene ontology (GO) terms. The meaning of an affected GO group is often clearer than interpretations arising from a list of the statistically significant genes. Results: Computer simulations demonstrated that correlations among genes invalidate many statistical methods that are commonly used to assign significance to GO terms. Ignoring these correlations overstates the statistical significance. Meta-analysis methods for combining p-values were modified to adjust for correlation. One of these methods is elaborated in the context of a comparison between two treatments. The form of the correlation adjustment depends upon the alternative hypothesis. Conclusion: Reliable corrections for the effect of correlations among genes on the significance level of a GO term can be constructed for an alternative hypothesis where all transcripts in the GO term increase (decrease) in response to treatment. For general alternatives, which allow some transcripts to increase and others to decrease, the bias of naïve significance calculations can be greatly decreased although not eliminated. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - GENE expression
KW - COMPUTER simulation
KW - GENES
KW - ONTOLOGY
KW - META-analysis
KW - STATISTICS
N1 - Accession Number: 28677539; Delongchamp, Robert 1; Email Address: robert.delongchamp@fda.hhs.gov Taewon Lee 1; Email Address: taewon.lee@fda.hhs.gov Velasco, Cruz 2; Email Address: cvelas@lsuhsc.edu; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, Arkansas 72079 USA 2: School of Public Health, LSU Health Science Center, New Orleans, LA 70112 USA; Source Info: 2006 Supplement 2, Vol. 7, pS11; Subject Term: DNA; Subject Term: GENE expression; Subject Term: COMPUTER simulation; Subject Term: GENES; Subject Term: ONTOLOGY; Subject Term: META-analysis; Subject Term: STATISTICS; Number of Pages: 9p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S11
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tao Chen
AU - Lei Guo
AU - Lu Zhang
AU - Leming Shi
AU - Hong Fang
AU - Yongming Sun
AU - Fuscoe, James C.
AU - Nan Mei
T1 - Gene Expression Profiles Distinguish the Carcinogenic Effects of Aristolochic Acid in Target (Kidney) and Non-target (Liver) Tissues in Rats.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2006/01/03/2006 Supplement 2
VL - 7
M3 - Article
SP - S20
EP - 13
PB - BioMed Central
SN - 14712105
AB - Background: Aristolochic acid (AA) is the active component of herbal drugs derived from Aristolochia species that have been used for medicinal purposes since antiquity. AA, however, induced nephropathy and urothelial cancer in people and malignant tumors in the kidney and urinary tract of rodents. Although AA is bioactivated in both kidney and liver, it only induces tumors in kidney. To evaluate whether microarray analysis can be used for distinguishing the tissue-specific carcinogenicity of AA, we examined gene expression profiles in kidney and liver of rats treated with carcinogenic doses of AA. Results: Microarray analysis was performed using the Rat Genome Survey Microarray and data analysis was carried out within ArrayTrack software. Principal components analysis and hierarchical cluster analysis of the expression profiles showed that samples were grouped together according to the tissues and treatments. The gene expression profiles were significantly altered by AA treatment in both kidney and liver (p < 0.01; fold change > 1.5). Functional analysis with Ingenuity Pathways Analysis showed that there were many more significantly altered genes involved in cancer-related pathways in kidney than in liver. Also, analysis with Gene Ontology for Functional Analysis (GOFFA) software indicated that the biological processes related to defense response, apoptosis and immune response were significantly altered by AA exposure in kidney, but not in liver. Conclusion: Our results suggest that microarray analysis is a useful tool for detecting AA exposure; that analysis of the gene expression profiles can define the differential responses to toxicity and carcinogenicity of AA from kidney and liver; and that significant alteration of genes associated with defense response, apoptosis and immune response in kidney, but not in liver, may be responsible for the tissue-specific toxicity and carcinogenicity of AA. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RATS
KW - RESEARCH
KW - GENES
KW - HEREDITY
KW - KIDNEYS
KW - LIVER
KW - CARCINOGENICITY
N1 - Accession Number: 28677548; Tao Chen 1; Email Address: tao.chen@fda.hhs.gov Lei Guo 2; Email Address: lei.guo@fda.hhs.gov Lu Zhang 3,4; Email Address: lzhang@solexa.com Leming Shi 2; Email Address: leming.shi@fda.hhs.gov Hong Fang 5; Email Address: hong.fang@fda.hhs.gov Yongming Sun 3; Email Address: sunya@appliedbiosystems.com; Fuscoe, James C. 2; Email Address: james.fuscoe@fda.hhs.gov Nan Mei 1; Email Address: nan.mei@fda.hhs.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA, 2: Division of Systems Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA 3: Molecular Biology SDS/Arrays Group, Applied BioSystems, Foster City, CA 94404, USA 4: Solexa, Inc., 25861 Industrial Boulevard Hayward, CA 94545, USA 5: Z-Tech Corporation, 3900 NCTR Road, Jefferson, Arkansas 72079 USA; Source Info: 2006 Supplement 2, Vol. 7, pS20; Subject Term: RATS; Subject Term: RESEARCH; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: KIDNEYS; Subject Term: LIVER; Subject Term: CARCINOGENICITY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-7-S2-S20
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Douglas, Pamela S.
AU - Eckel, Robert H.
AU - Gray, Darryl T.
AU - Loeb, Jerod M.
AU - Straube, Barry M.
T1 - Coming Together to Achieve Quality Cardiovascular Care
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2006/01/03/
VL - 47
IS - 1
M3 - Editorial
SP - 266
EP - 267
SN - 07351097
N1 - Accession Number: 19339292; Douglas, Pamela S. 1 Eckel, Robert H. 2 Gray, Darryl T. 3 Loeb, Jerod M. 4 Straube, Barry M. 5; Affiliation: 1: President, American College of Cardiology, Bethesda, Maryland, and the Duke University Medical Center, Durham, North Carolina 2: President, American Heart Association, Dallas, Texas, and the University of Colorado Health Sciences Center, Denver, Colorado 3: Medical Officer, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, Maryland 4: Executive Vice President, Division of Research, Joint Commission on Accreditation of Healthcare Organizations, Oakbrook Terrace, Illinois 5: Acting Chief Medical Officer and Director, Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, Maryland; Source Info: Jan2006, Vol. 47 Issue 1, p266; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chekhun, Vasil F.
AU - Kulik, Galina I.
AU - Yurchenko, Olga V.
AU - Tryndyak, Volodymyr P.
AU - Todor, Igor N.
AU - Luniv, Liliana S.
AU - Tregubova, Nadiya A.
AU - Pryzimirska, Tamara V.
AU - Montgomery, Beverly
AU - Rusetskaya, Nataliya V.
AU - Pogribny, Igor P.
T1 - Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2006/01/08/
VL - 231
IS - 1
M3 - Article
SP - 87
EP - 93
SN - 03043835
AB - Abstract: The resistance of cancer cells to chemotherapeutic agents is a major clinical problem and an important cause of treatment failure in cancer. Mechanisms that have developed to guard cancer cells against anti-cancer drugs are major barriers to successful anti-cancer therapy. Therefore, the identification of novel mechanisms of cellular resistance holds the promise of leading to better treatments for cancer patients. In the present study, we used human MCF-7 breast adenocarcinoma cell line and its doxorubicin-resistant variant MCF-7/R to determine the role of alterations of DNA methylation of chemoresitance-related genes, such as multidrug resistance 1 (MDR1), glutathione-S-transferase (GSTπ), O6-methylguanine DNA methyltransferase (MGMT), and urokinase (Upa), in the development of drug resistance. The promoter regions of MDR1, GSTπ, MGMT, and Upa genes were highly methylated in MCF-7 cell line but not in its MCF-7/R drug resistant variant. The hypomethylated status of MDR1 gene was associated with overexpression of P-glycoprotein. We hypothesize that acquirement of doxorubicin resistance of MCF-7 cells is associated with DNA hypomethylation of the promoter regions of the MDR1, GSTπ, MGMT, and Upa genes. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - CANCER patients
KW - NUCLEIC acids
KW - DNA
KW - DNA hypomethylation
KW - Doxorubicin resistance
KW - MCF-7 cells
N1 - Accession Number: 19201759; Chekhun, Vasil F. 1 Kulik, Galina I. 1 Yurchenko, Olga V. 1 Tryndyak, Volodymyr P. 1 Todor, Igor N. 1 Luniv, Liliana S. 1 Tregubova, Nadiya A. 1 Pryzimirska, Tamara V. 1 Montgomery, Beverly 2 Rusetskaya, Nataliya V. 1 Pogribny, Igor P. 2; Email Address: ipogribny@nctr.fda.gov; Affiliation: 1: Department of Mechanisms of Anticancer Therapy, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Jan2006, Vol. 231 Issue 1, p87; Subject Term: CANCER treatment; Subject Term: CANCER patients; Subject Term: NUCLEIC acids; Subject Term: DNA; Author-Supplied Keyword: DNA hypomethylation; Author-Supplied Keyword: Doxorubicin resistance; Author-Supplied Keyword: MCF-7 cells; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.canlet.2005.01.038
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xia, Qingsu
AU - Chou, Ming W.
AU - Edgar, John A.
AU - Doerge, Daniel R.
AU - Fu, Peter P.
T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2006/01/08/
VL - 231
IS - 1
M3 - Article
SP - 138
EP - 145
SN - 03043835
AB - Abstract: Pyrrolizidine alkaloids (PAs) are probably the most common poisonous plants affecting livestock, wildlife, and humans. The PAs that have been found to be tumorigenic in experimental animals belong to the retronecine-, heliotridine-, and otonecine-type PAs. Our recent mechanistic studies indicated that riddelliine, a tumorigenic retronecine-type PA, induced tumors via a genotoxic mechanism mediated by the formation of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. The same adducts were formed from clivorine, a tumorigenic otonecine-type PA from metabolism of clivorine by rat liver microsomes in the presence of calf thymus DNA. In this study, we report that metabolism of lasiocarpine, the prototype heliotridine PA, by F344 rat liver microsomes resulted in the formation of DHP. When incubated in the presence of calf thymus DNA, the same DHP-derived DNA adducts were formed. These results suggest that these DHP-derived DNA adducts are potential biomarkers of exposure and tumorigenicity for all types of PAs. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - DNA
KW - BIOTRANSFORMATION (Metabolism)
KW - METABOLISM
KW - Biomarker
KW - DNA adduct
KW - Lasiocarpine
KW - Pyrrolizidine alkaloid
N1 - Accession Number: 19201765; Xia, Qingsu 1 Chou, Ming W. 1 Edgar, John A. 2 Doerge, Daniel R. 1 Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT0-110, Jefferson, AR 72079, USA 2: CSIRO Livestock Industries, PB 24, Geelong, Vic. 3220, Australia; Source Info: Jan2006, Vol. 231 Issue 1, p138; Subject Term: NUCLEIC acids; Subject Term: DNA; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: METABOLISM; Author-Supplied Keyword: Biomarker; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: Lasiocarpine; Author-Supplied Keyword: Pyrrolizidine alkaloid; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.canlet.2005.01.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19201765&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leonard, Stephen S.
AU - Keil, Deborah
AU - Mehlman, Tracey
AU - Proper, Steven
AU - Shi, Xianglin
AU - Harris, Gabriel K.
T1 - Essiac tea: Scavenging of reactive oxygen species and effects on DNA damage
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2006/01/16/
VL - 103
IS - 2
M3 - Article
SP - 288
EP - 296
SN - 03788741
AB - Abstract: Essiac, a tea reportedly developed by the Ojibwa tribe of Canada and widely publicized as a homeopathic cancer treatment, is prepared from a mixture of four herbs Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. Each of these herbs has been reported to possess antioxidant and anti-cancer activity. Essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a matter of debate. We prepared an extract of Essiac tea from a concentration of 25mg/mL and boiled it for 10min. From this preparation we used concentrations of 5, 10, 25 and 50% to measure Essiac effects. In this study, we examined the effects of Essiac on free radical scavenging and DNA damage in a non-cellular system, as well as the effects Essiac on lipid peroxidation using the RAW 264.7 cell line. We observed, using electron spin resonance, that Essiac effectively scavenged hydroxyl, up to 84% reduction in radical signal at the 50% tea preparation concentration, and superoxide radicals, up to 82% reduction in radical signal also at the 50% tea preparation concentration, as well as prevented hydroxyl radical-induced DNA damage. In addition, Essiac inhibited hydroxyl radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac. [Copyright &y& Elsevier]
AB - Copyright of Journal of Ethnopharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - TUMORS
KW - MEDICAL botany
KW - DRUG therapy
KW - 1
KW - 1,1-diphenyl-2-picrylhydrazyl ( DPPH )
KW - 1-diphenyl-2-picrylhydrazyl ( DPPH )
KW - 5
KW - 5,5-dimethyl-1-pyrroline N-oxide ( DMPO )
KW - 5-dimethyl-1-pyrroline N-oxide ( DMPO )
KW - DNA damage
KW - Dulbecco's Modified Eagles Media ( DMEM )
KW - electron spin resonance ( ESR )
KW - ESR
KW - Essiac tea
KW - ethylenediaminetetraacetic acid ( EDTA )
KW - fetal bovine serum ( FBS )
KW - Lipid peroxidation
KW - malondialdehyde ( MDA )
KW - phosphate-buffered saline ( PBS )
KW - Reactive oxygen species
KW - reactive oxygen species ( ROS )
N1 - Accession Number: 19200291; Leonard, Stephen S. 1; Email Address: SEL5@cdc.gov Keil, Deborah 2 Mehlman, Tracey 2 Proper, Steven 1 Shi, Xianglin 1 Harris, Gabriel K. 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS/2015, Morgantown, WV 26505, USA 2: Allergen and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS/2015, Morgantown, WV 26505, USA; Source Info: Jan2006, Vol. 103 Issue 2, p288; Subject Term: CANCER treatment; Subject Term: TUMORS; Subject Term: MEDICAL botany; Subject Term: DRUG therapy; Author-Supplied Keyword: 1; Author-Supplied Keyword: 1,1-diphenyl-2-picrylhydrazyl ( DPPH ); Author-Supplied Keyword: 1-diphenyl-2-picrylhydrazyl ( DPPH ); Author-Supplied Keyword: 5; Author-Supplied Keyword: 5,5-dimethyl-1-pyrroline N-oxide ( DMPO ); Author-Supplied Keyword: 5-dimethyl-1-pyrroline N-oxide ( DMPO ); Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: Dulbecco's Modified Eagles Media ( DMEM ); Author-Supplied Keyword: electron spin resonance ( ESR ); Author-Supplied Keyword: ESR; Author-Supplied Keyword: Essiac tea; Author-Supplied Keyword: ethylenediaminetetraacetic acid ( EDTA ); Author-Supplied Keyword: fetal bovine serum ( FBS ); Author-Supplied Keyword: Lipid peroxidation; Author-Supplied Keyword: malondialdehyde ( MDA ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: reactive oxygen species ( ROS ); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jep.2005.09.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19200291&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106436423
T1 - Essiac tea: scavenging of reactive oxygen species and effects on DNA damage.
AU - Leonard SS
AU - Keil D
AU - Mehlman T
AU - Proper S
AU - Shi X
AU - Harris GK
Y1 - 2006/01/16/
N1 - Accession Number: 106436423. Language: English. Entry Date: 20060505. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Alternative/Complementary Therapies; Biomedical; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 7903310.
KW - Medicine, Herbal -- Canada
KW - Tea -- Canada
KW - Antioxidants
KW - Free Radicals -- Drug Effects
KW - Lipid Peroxidation -- Drug Effects
KW - DNA -- Drug Effects
KW - Canada
KW - In Vitro Studies
KW - Descriptive Statistics
KW - One-Way Analysis of Variance
KW - Data Analysis Software
KW - Human
SP - 288
EP - 296
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
JA - J ETHNOPHARMACOL
VL - 103
IS - 2
PB - Elsevier Science
AB - Essiac, a tea reportedly developed by the Ojibwa tribe of Canada and widely publicized as a homeopathic cancer treatment, is prepared from a mixture of four herbs Arctium lappa, Rumex acetosella, Ulmus rubra and Rheum officinale. Each of these herbs has been reported to possess antioxidant and anti-cancer activity. Essiac itself has also been reported to demonstrate anti-cancer activity in vitro, although its effects in vivo are still a matter of debate. We prepared an extract of Essiac tea from a concentration of 25mg/mL and boiled it for 10 min. From this preparation we used concentrations of 5, 10, 25 and 50% to measure Essiac effects. In this study, we examined the effects of Essiac on free radical scavenging and DNA damage in a non-cellular system, as well as the effects Essiac on lipid peroxidation using the RAW 264.7 cell line. We observed, using electron spin resonance, that Essiac effectively scavenged hydroxyl, up to 84% reduction in radical signal at the 50% tea preparation concentration, and superoxide radicals, up to 82% reduction in radical signal also at the 50% tea preparation concentration, as well as prevented hydroxyl radical-induced DNA damage. In addition, Essiac inhibited hydroxyl radical-induced lipid peroxidation by up to 50% at the 50% tea preparation concentration. These data indicate that Essiac tea possesses potent antioxidant and DNA-protective activity, properties that are common to natural anti-cancer agents. This study may help to explain the mechanisms behind the reported anti-cancer effects of Essiac.
SN - 0378-8741
AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS/2015, Morgantown, WV 26505
U2 - PMID: 16226859.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106436423&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Prater, M. Renee
AU - Johnson, Victor J.
AU - Germolec, Dori R.
AU - Luster, Michael I.
AU - Holladay, Steven D.
T1 - Maternal treatment with a high dose of CpG ODN during gestation alters fetal craniofacial and distal limb development in C57BL/6 mice
JO - Vaccine
JF - Vaccine
Y1 - 2006/01/16/
VL - 24
IS - 3
M3 - Article
SP - 263
EP - 271
SN - 0264410X
AB - Abstract: Synthetic oligodeoxynucleotides (ODN) containing CpG motifs, characteristic of bacterial DNA, are currently being evaluated as vaccine adjuvants for inducing protective immunity. Recently, there is increasing pressure to vaccinate pregnant women against maternally transmitted diseases including AIDS and tetanus, as well as against potential bio-weapons such as anthrax. CpG vaccines are effective because they trigger transient increases in TH1 cytokine production. Recent literature suggests, however, that a shift toward a TH1 cytokine profile during pregnancy may increase the risk of fetal morphologic defects. On this basis, we hypothesized that exposure to CpG motifs during pregnancy could result in TH1 inflammation leading to adverse effects on fetal development. To address this hypothesis, pregnant C57BL/6 mice were injected with CpG ODN (0–300μg/dam) and maternal and fetal outcomes were determined. Injection of dams with the highest dose of CpG ODN resulted in markedly increased fetal resorptions and craniofacial/limb defects, while lower doses had little, if any effects. Histological examination of placentas revealed cellular necrosis with mixed inflammation and calcification in the spongiotrophoblast layer and dysregulation of labyrinthine vascular development. Concomitant elevations in maternal serum cytokine levels were observed including interleukin (IL)-2, IL-10 and IL-12. Treatment with 300μg of non-CpG ODN did not cause any adverse effects. The 300μg dose of CpG ODN used in the present study is 30-fold higher than the highest dose that has been administered to humans during clinical trials. These results suggest that the induction of TH1 cytokines during pregnancy by CpG motifs may potentially increase the risk of fetal loss and morphologic defects in mice, at least at high doses, and support the need for further investigation of teratogenesis that may result from exposure to vaccine adjuvants designed to produce TH1 cytokine profile shifts. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cellular immunity
KW - Pregnancy
KW - Pregnant women
KW - Immunological adjuvants
KW - Abortion
KW - CpG ODN
KW - Craniofacial and distal limb development
KW - Fetal malformation
KW - Immunostimulatory DNA
KW - Th1 cytokine shift
N1 - Accession Number: 19201530; Prater, M. Renee 1,2; Johnson, Victor J. 3; Email Address: vjohnson3@cdc.gov; Germolec, Dori R. 4; Luster, Michael I. 3; Holladay, Steven D. 2; Affiliations: 1: The Edward Via Virginia College of Osteopathic Medicine, Department of Biomedical Sciences, 2265 Kraft Drive, Blacksburg, VA 24060, USA; 2: Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Department of Biomedical Sciences and Pathobiology, Phase II Duck Pond Drive, Blacksburg, VA 24061, USA; 3: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willow Road, Morgantown, WV 26505, USA; 4: Laboratory of Molecular Toxicology/National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Issue Info: Jan2006, Vol. 24 Issue 3, p263; Thesaurus Term: Cellular immunity; Subject Term: Pregnancy; Subject Term: Pregnant women; Subject Term: Immunological adjuvants; Author-Supplied Keyword: Abortion; Author-Supplied Keyword: CpG ODN; Author-Supplied Keyword: Craniofacial and distal limb development; Author-Supplied Keyword: Fetal malformation; Author-Supplied Keyword: Immunostimulatory DNA; Author-Supplied Keyword: Th1 cytokine shift; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.07.105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19201530&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - O'Connell, Kethryn A.
AU - Wood, Jennifer J.
AU - Wise, Robert P.
AU - Lozier, Jay N.
AU - Braun, M. Miles
T1 - Thromboembolic Adverse Events After Use of Recombinant Human Coagulation Factor Vlla.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/01/18/
VL - 295
IS - 3
M3 - Abstract
SP - 293
EP - 298
SN - 00987484
AB - The article discusses a study on thromboembolic adverse events, which were reported to the U.S. Food and Drug Administration's Adverse Event Reporting System, after use of recombinant human coagulation factor Vlla (rFVlla). The FVlla is used to control bleeding in hemophilia patients and reportedly has been used off-label in patients without hemophilia. Research methods included analysis with Premier RxMarket Advisor. Data showing the extent of use, patient demographics, reasons for use, and number of thromboembolic events is provided, as well as reported deaths. The study found that morbidity or mortality occurred more when rFVlla was used for unlabeled indications.
KW - BLOOD coagulation factors
KW - HEMOPHILIACS
KW - MEDICAL care
KW - THROMBOEMBOLISM
KW - EXPERIMENTAL therapeutics
KW - MEDICAL care -- Research
KW - DRUGS -- Side effects
KW - PUBLIC health surveillance
KW - BLOOD coagulation
KW - HEMOPHILIA -- Treatment
KW - MEDICAL research
KW - RESEARCH -- Methodology
KW - THERAPEUTIC use
KW - RISK factors
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 19430956; O'Connell, Kethryn A. 1; Email Address: oconnellk@cber.fda.gov Wood, Jennifer J. 1,2 Wise, Robert P. 1 Lozier, Jay N. 3 Braun, M. Miles 1; Affiliation: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md. 2: Cordis Corporation, Miami Lakes, Fla. 3: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md.; Source Info: 1/18/2006, Vol. 295 Issue 3, p293; Subject Term: BLOOD coagulation factors; Subject Term: HEMOPHILIACS; Subject Term: MEDICAL care; Subject Term: THROMBOEMBOLISM; Subject Term: EXPERIMENTAL therapeutics; Subject Term: MEDICAL care -- Research; Subject Term: DRUGS -- Side effects; Subject Term: PUBLIC health surveillance; Subject Term: BLOOD coagulation; Subject Term: HEMOPHILIA -- Treatment; Subject Term: MEDICAL research; Subject Term: RESEARCH -- Methodology; Subject Term: THERAPEUTIC use; Subject Term: RISK factors; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Illustrations: 2 Charts, 5 Graphs; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106330774
T1 - Thromboembolic adverse events after use of recombinant human coagulation factor VIIa.
AU - O'Connell KA
AU - Wood JJ
AU - Wise RP
AU - Lozier JN
AU - Braun MM
Y1 - 2006/01/18/
N1 - Accession Number: 106330774. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Blood Coagulation Factors -- Adverse Effects
KW - Recombinant Proteins -- Adverse Effects
KW - Thromboembolism -- Chemically Induced
KW - Adolescence
KW - Adult
KW - Adverse Drug Event
KW - Aged
KW - Aged, 80 and Over
KW - Blood Coagulation Factors -- Therapeutic Use
KW - Child
KW - Child, Preschool
KW - Fatal Outcome
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Age
KW - Recombinant Proteins -- Therapeutic Use
KW - Thromboembolism -- Epidemiology
KW - Human
SP - 293
EP - 298
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 295
IS - 3
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Division of Epidemiology (HFM-224), Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448; oconnellk@cber.fda.gov
U2 - PMID: 16418464.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106330774&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Choi, Sun Ok
AU - Um, So Young
AU - Jung, Sung Hee
AU - Jung, Seo Jeong
AU - Kim, Joo Il
AU - Lee, Hwa Jeong
AU - Chung, Soo Youn
T1 - Column-switching high-performance liquid chromatographic method for the determination of zaltoprofen in rat plasma
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/01/18/
VL - 830
IS - 2
M3 - Article
SP - 301
EP - 305
SN - 15700232
AB - Abstract: A direct injection column-switching high-performance liquid chromatography (HPLC) method was developed and validated for quantification of zaltoprofen in rat plasma. Following dilution with mobile phase A, i.e. acetonitrile-10mM potassium phosphate buffer (pH 6.8) (12:88, v/v) samples were directly injected to the pre-column without sample pre-purification step. After endogenous plasma components were eluted to waste, the system was switched and the analyte was eluted to the trap column. Zaltoprofen was then back-flushed to the analytical column for separation with mobile phase B, i.e. acetonitrile–10mM potassium phosphate buffer (pH 6.8) (35:65, v/v) and quantification with an ultraviolet detector at 230nm. The calibration curve was linear in the concentration range of 40–5000ngmL−1. This method has been fully validated and shown to be specific, accurate and precise. The method is simple, rapid and the sample preparation is minimal and appears to be useful for the pharmacokinetic study of zaltoprofen. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - BLOOD plasma
KW - ACETONITRILE
KW - DILUTION
KW - LIQUID chromatography
KW - Column switching
KW - Direct injection
KW - High-performance liquid chromatography (HPLC)
KW - Rat plasma
KW - Zaltoprofen
N1 - Accession Number: 19396436; Choi, Sun Ok 1; Email Address: sochoi@kfda.go.kr Um, So Young 1 Jung, Sung Hee 1 Jung, Seo Jeong 1 Kim, Joo Il 1 Lee, Hwa Jeong 2 Chung, Soo Youn 1; Affiliation: 1: Division of Biopharmaceutics, Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, Nokbun-dong 5, Eunpyung-Ku, Seoul, South Korea 2: School of pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-Ku, Seoul, South Korea; Source Info: Jan2006, Vol. 830 Issue 2, p301; Subject Term: HIGH performance liquid chromatography; Subject Term: BLOOD plasma; Subject Term: ACETONITRILE; Subject Term: DILUTION; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Column switching; Author-Supplied Keyword: Direct injection; Author-Supplied Keyword: High-performance liquid chromatography (HPLC); Author-Supplied Keyword: Rat plasma; Author-Supplied Keyword: Zaltoprofen; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jchromb.2005.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19396436&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martella, Vito
AU - Bányai, Krisztián
AU - Ciarlet, Max
AU - Iturriza-Gómara, Miren
AU - Lorusso, Eleonora
AU - De Grazia, Simona
AU - Arista, Serenella
AU - Decaro, Nicola
AU - Elia, Gabriella
AU - Cavalli, Alessandra
AU - Corrente, Marialaura
AU - Lavazza, Antonio
AU - Baselga, Rafael
AU - Buonavoglia, Canio
T1 - Relationships among porcine and human P[6] rotaviruses: Evidence that the different human P[6] lineages have originated from multiple interspecies transmission events
JO - Virology
JF - Virology
Y1 - 2006/01/20/
VL - 344
IS - 2
M3 - Article
SP - 509
EP - 519
SN - 00426822
AB - Abstract: Porcine rotavirus strains (PoRVs) bearing human-like VP4 P[6] gene alleles were identified. Genetic characterization with either PCR genotyping or sequence analysis allowed to determine the VP7 specificity of the PoRVs as G3, G4, G5 and G9, and the VP6 as genogroup I, that is predictive of a subgroup I specificity. Sequence analysis of the VP8* trypsin-cleavage product of VP4 allowed PoRVs to be characterized further into genetic lineages within the P[6] genotype. Unexpectedly, the strains displayed significantly higher similarity (up to 94.6% and 92.5% at aa and nt level, respectively) to human M37-like P[6] strains (lineage I), serologically classifiable as P2A, or to the atypical Hungarian P[6] human strains (HRVs), designated as lineage V (up to 97.0% aa and 96.1% nt), than to the porcine P[6] strain Gottfried, lineage II (<85.1% aa and 82.2 nt), which is serologically classified as P2B. Interestingly, no P[6] PoRV resembling the original prototype porcine strain, Gottfried, was detected, while Japanase P[6] PoRV clustered with the atypical Japanase G1 human strain AU19. By analysis of the 10th and 11th genome segments, all the strains revealed a NSP4B genogroup (Wa-like) and a NSP5/6 gene of porcine origin. These findings strongly suggest interspecies transmission of rotavirus strains and/or genes, and may indicate the occurrence of at least 3 separate rotavirus transmission events between pigs and humans, providing convincing evidence that evolution of human rotaviruses is tightly intermingled with the evolution of animal rotaviruses. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - DIGESTIVE enzymes
KW - PANCREATIC secretions
KW - GENETIC research
KW - Genotyping
KW - Porcine rotaviruses
KW - P[6]
KW - VP4
N1 - Accession Number: 19357951; Martella, Vito 1; Email Address: v.martella@veterinaria.uniba.it Bányai, Krisztián 2 Ciarlet, Max 3 Iturriza-Gómara, Miren 4 Lorusso, Eleonora 1 De Grazia, Simona 5 Arista, Serenella 5 Decaro, Nicola 1 Elia, Gabriella 1 Cavalli, Alessandra 1 Corrente, Marialaura 1 Lavazza, Antonio 6 Baselga, Rafael 7 Buonavoglia, Canio 1; Affiliation: 1: Dipartimento di Sanità e Benessere Animale, Facoltà di Medicina Veterinaria di Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Hungary 3: Department of Biologics-Clinical Research, Merck and Co., Inc., Blue Bell, PA 19422, USA 4: Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK 5: Dipartimento di Igiene e Microbiologia, Università di Palermo, Italy 6: Istituto Zooprofilattico Sperimentale di Lombardia/Emilia Romagna, Brescia, Italy 7: Exopol, Saragoza, Spain; Source Info: Jan2006, Vol. 344 Issue 2, p509; Subject Term: GENETIC polymorphisms; Subject Term: DIGESTIVE enzymes; Subject Term: PANCREATIC secretions; Subject Term: GENETIC research; Author-Supplied Keyword: Genotyping; Author-Supplied Keyword: Porcine rotaviruses; Author-Supplied Keyword: P[6]; Author-Supplied Keyword: VP4; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.virol.2005.08.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19357951&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lutterman, Daniel A.
AU - Fu, Patty K.-L.
AU - Turro, Claudia
T1 - Cis-[Rh2(u-O2CCH3)2(CH3CN)6]²+ as a Photoactivated Cisplatin Analog.
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
Y1 - 2006/01/25/
VL - 128
IS - 3
M3 - Article
SP - 738
EP - 739
SN - 00027863
AB - The article looks into the significance of cisplatin as a successful antitumor agent against various forms of cancer. Significantly, the selectivity toward tumor tissue can be achieved through the activation of drugs by light wherein a molecule that has no or low toxicity in the dark becomes highly toxic upon irradiation with low energy light. Furthermore, the previously established that the axial ligands of the compound exchange readily with coordinating solvent molecules. Photolysis of the compound in the presence of linearized plasmid results in decreased mobility of the ds-DNA on an agarose gel.
KW - CISPLATIN
KW - ALKYLATING agents
KW - ANTINEOPLASTIC agents
KW - CHEMOTHERAPY (Cancer)
KW - CANCER treatment
KW - TOXICITY testing
KW - EXPERIMENTAL toxicology
N1 - Accession Number: 20217807; Lutterman, Daniel A. 1 Fu, Patty K.-L. 2 Turro, Claudia 1; Email Address: turro@chemistry.ohio-state.edu; Affiliation: 1: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210 2: U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740; Source Info: 1/25/2006, Vol. 128 Issue 3, p738; Subject Term: CISPLATIN; Subject Term: ALKYLATING agents; Subject Term: ANTINEOPLASTIC agents; Subject Term: CHEMOTHERAPY (Cancer); Subject Term: CANCER treatment; Subject Term: TOXICITY testing; Subject Term: EXPERIMENTAL toxicology; Number of Pages: 2p; Illustrations: 2 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Benkovic, Stanley Anthony
AU - O'Callaghan, James Patrick
AU - Miller, Diane Bemis
T1 - Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice
JO - Brain Research
JF - Brain Research
Y1 - 2006/01/27/
VL - 1070
IS - 1
M3 - Article
SP - 215
EP - 231
SN - 00068993
AB - Abstract: We evaluated regional neuropathological changes in adult and aged male mice treated systemically with kainic acid (KA) in a strain reported to be resistant to excitotoxic neuronal damage, C57BL/6. KA was administered in a single intraperitoneal injection. Adult animals were dosed with 35 mg/kg KA, while aged animals received a dose of 20 mg/kg in order to prevent excessive mortality. At time-points ranging from 12 h to 7 days post-treatment, animals were sacrificed and prepared for histological evaluation utilizing the cupric-silver neurodegeneration stain, immunohistochemistry for GFAP and IgG, and lectin staining. In animals of both ages, KA produced argyrophilia in neurons throughout cortex, hippocampus, thalamus, and amygdala. Semi-quantitative analysis of neuropathology revealed a similar magnitude of damage in animals of both ages, even though aged animals received less toxicant. Additional animals were evaluated for KA-induced reactive gliosis, assayed by an ELISA for GFAP, which revealed a 2-fold elevation in protein levels in adult mice, and a 2.5-fold elevation in aged animals. Histochemical evaluation of GFAP and lectin staining revealed activation of astrocytes and microglia in regions with corresponding argyrophilia. IgG immunostaining revealed a KA-induced breach of the blood–brain barrier in animals of both ages. Our data indicate widespread neurotoxicity following kainic acid treatment in C57BL/6J mice, and reveal increased sensitivity to this excitotoxicant in aged animals. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NERVOUS system -- Diseases
KW - KAINIC acid
KW - INTRAPERITONEAL injections
KW - NEUROTOXICOLOGY
KW - NEUROPHYSIOLOGY
KW - RESEARCH
KW - NEURONS
KW - 3–3′ diaminobenzidine tetrahydrochloride ( DAB )
KW - Age factor
KW - alveus hippocampi ( ah )
KW - amygdala ( amyg )
KW - analysis of variance ( ANOVA )
KW - area transitionalis corticoamygdaloidea ( atc )
KW - avidin–biotin complex ( ABC )
KW - bicinchoninic acid ( BCA )
KW - caudate nucleus ( cn )
KW - Centers for Disease Control and Prevention ( CDC )
KW - cornu ammonis region 1 ( CA1 )
KW - cornu ammonis region 3 ( CA3 )
KW - cortex cerebri, area cinguli ( ccac )
KW - cortex cerebri, layer III ( III )
KW - cortex cerebri, layer VI ( VI )
KW - Dulbecco's modified phosphate buffered saline ( DPBS )
KW - electroencephalogram ( EEG )
KW - entorhinal cortex ( ectx )
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - Excitotoxicity
KW - frontal cortex ( fctx )
KW - glial fibrillary acidic protein ( GFAP )
KW - Gliosis
KW - Griffonia simplicifolia isolectin B4 ( IsoB4 )
KW - hilus fasciae dentatae ( hfd )
KW - hippocampus ( hip )
KW - horseradish peroxidase ( HRP )
KW - id est ( i.e. )
KW - immunoglobulin G ( IgG )
KW - intraperitoneal ( i.p. )
KW - kainic acid ( KA )
KW - lamina principalis externa areae entorhinalis ( lpeae )
KW - lamina principalis interna areae entorhinalis ( lpiae )
KW - National Institute for Occupational Safety and Health ( NIOSH )
KW - Neuropathology
KW - NeuroScience Associates ( NSA )
KW - nucleus amygdaloideus basalis ( nab )
KW - nucleus amygdaloideus corticalis ( nac )
KW - nucleus amygdaloideus medialis ( nam )
KW - nucleus anterior hypothalami ( nah )
KW - nucleus anteroventralis thalami ( nat )
KW - nucleus lateralis hypothalami ( nlh )
KW - nucleus lateralis septi ( nls )
KW - nucleus medialis septi ( nms )
KW - nucleus paratenialis thalami ( npt )
KW - nucleus paraventricularis thalami ( npvt )
KW - nucleus reticularis thalami ( nrt )
KW - nucleus triangularis septi ( nts )
KW - nucleus ventralis thalami, pars anterior ( nvtpa )
KW - nucleus ventralis thalami, pars dorsalis ( nvtpd )
KW - nucleus ventricularis hypothalami ( nvh )
KW - parasubiculum ( ps )
KW - phosphate buffered saline ( PBS )
KW - radiatio corporis callosi ( rcc )
KW - room temperature ( RT )
KW - sodium dodecyl sulfate ( SDS )
KW - splenium corporis callosi ( scc )
KW - standard error of the mean ( SEM )
KW - stratum lacunosum-moleculare hippocampi ( sl-m )
KW - stratum moleculare areae interna dentatae ( smaid )
KW - stratum oriens hippocampi ( so )
KW - stratum pyramidale hippocampi ( sp )
KW - stratum pyramidale subiculi ( sps )
KW - stratum radiatum hippocampi ( sr )
KW - thalamus ( thal )
KW - truncus corporis callosi ( tcc )
N1 - Accession Number: 19771185; Benkovic, Stanley Anthony 1 O'Callaghan, James Patrick 1 Miller, Diane Bemis; Email Address: dum6@cdc.gov; Affiliation: 1: Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention-National Institute for Occupational, Safety and Health, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Jan2006, Vol. 1070 Issue 1, p215; Subject Term: NERVOUS system -- Diseases; Subject Term: KAINIC acid; Subject Term: INTRAPERITONEAL injections; Subject Term: NEUROTOXICOLOGY; Subject Term: NEUROPHYSIOLOGY; Subject Term: RESEARCH; Subject Term: NEURONS; Author-Supplied Keyword: 3–3′ diaminobenzidine tetrahydrochloride ( DAB ); Author-Supplied Keyword: Age factor; Author-Supplied Keyword: alveus hippocampi ( ah ); Author-Supplied Keyword: amygdala ( amyg ); Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: area transitionalis corticoamygdaloidea ( atc ); Author-Supplied Keyword: avidin–biotin complex ( ABC ); Author-Supplied Keyword: bicinchoninic acid ( BCA ); Author-Supplied Keyword: caudate nucleus ( cn ); Author-Supplied Keyword: Centers for Disease Control and Prevention ( CDC ); Author-Supplied Keyword: cornu ammonis region 1 ( CA1 ); Author-Supplied Keyword: cornu ammonis region 3 ( CA3 ); Author-Supplied Keyword: cortex cerebri, area cinguli ( ccac ); Author-Supplied Keyword: cortex cerebri, layer III ( III ); Author-Supplied Keyword: cortex cerebri, layer VI ( VI ); Author-Supplied Keyword: Dulbecco's modified phosphate buffered saline ( DPBS ); Author-Supplied Keyword: electroencephalogram ( EEG ); Author-Supplied Keyword: entorhinal cortex ( ectx ); Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: Excitotoxicity; Author-Supplied Keyword: frontal cortex ( fctx ); Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: Gliosis; Author-Supplied Keyword: Griffonia simplicifolia isolectin B4 ( IsoB4 ); Author-Supplied Keyword: hilus fasciae dentatae ( hfd ); Author-Supplied Keyword: hippocampus ( hip ); Author-Supplied Keyword: horseradish peroxidase ( HRP ); Author-Supplied Keyword: id est ( i.e. ); Author-Supplied Keyword: immunoglobulin G ( IgG ); Author-Supplied Keyword: intraperitoneal ( i.p. ); Author-Supplied Keyword: kainic acid ( KA ); Author-Supplied Keyword: lamina principalis externa areae entorhinalis ( lpeae ); Author-Supplied Keyword: lamina principalis interna areae entorhinalis ( lpiae ); Author-Supplied Keyword: National Institute for Occupational Safety and Health ( NIOSH ); Author-Supplied Keyword: Neuropathology; Author-Supplied Keyword: NeuroScience Associates ( NSA ); Author-Supplied Keyword: nucleus amygdaloideus basalis ( nab ); Author-Supplied Keyword: nucleus amygdaloideus corticalis ( nac ); Author-Supplied Keyword: nucleus amygdaloideus medialis ( nam ); Author-Supplied Keyword: nucleus anterior hypothalami ( nah ); Author-Supplied Keyword: nucleus anteroventralis thalami ( nat ); Author-Supplied Keyword: nucleus lateralis hypothalami ( nlh ); Author-Supplied Keyword: nucleus lateralis septi ( nls ); Author-Supplied Keyword: nucleus medialis septi ( nms ); Author-Supplied Keyword: nucleus paratenialis thalami ( npt ); Author-Supplied Keyword: nucleus paraventricularis thalami ( npvt ); Author-Supplied Keyword: nucleus reticularis thalami ( nrt ); Author-Supplied Keyword: nucleus triangularis septi ( nts ); Author-Supplied Keyword: nucleus ventralis thalami, pars anterior ( nvtpa ); Author-Supplied Keyword: nucleus ventralis thalami, pars dorsalis ( nvtpd ); Author-Supplied Keyword: nucleus ventricularis hypothalami ( nvh ); Author-Supplied Keyword: parasubiculum ( ps ); Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: radiatio corporis callosi ( rcc ); Author-Supplied Keyword: room temperature ( RT ); Author-Supplied Keyword: sodium dodecyl sulfate ( SDS ); Author-Supplied Keyword: splenium corporis callosi ( scc ); Author-Supplied Keyword: standard error of the mean ( SEM ); Author-Supplied Keyword: stratum lacunosum-moleculare hippocampi ( sl-m ); Author-Supplied Keyword: stratum moleculare areae interna dentatae ( smaid ); Author-Supplied Keyword: stratum oriens hippocampi ( so ); Author-Supplied Keyword: stratum pyramidale hippocampi ( sp ); Author-Supplied Keyword: stratum pyramidale subiculi ( sps ); Author-Supplied Keyword: stratum radiatum hippocampi ( sr ); Author-Supplied Keyword: thalamus ( thal ); Author-Supplied Keyword: truncus corporis callosi ( tcc ); Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.brainres.2005.11.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Ross, Sharon A.
AU - Wise, Carolyn
AU - Pogribna, Marta
AU - Jones, Elisabeth A.
AU - Tryndyak, Volodymyr P.
AU - James, S. Jill
AU - Dragan, Yvonne P.
AU - Poirier, Lionel A.
T1 - Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2006/01/29/
VL - 593
IS - 1/2
M3 - Article
SP - 80
EP - 87
SN - 00275107
AB - Abstract: Dietary methyl group deprivation is now well recognized as a model of hepatocarcinogenesis in rodents. In the present study, we examined the effects of feeding a methyl-deficient diet followed by a methyl-adequate diet on the extent of methylation of liver DNA and on the formation and evolution of altered hepatic foci. Male F344 rats were fed a methyl-deficient diet for 9, 18, 24, and 36 weeks, followed by re-feeding a methyl-adequate diet for a total of 54 weeks. Similar to previous findings, the methyl-deficient diet resulted in decreased levels of S-adenosylmethionine (SAM), SAM/SAH ratios, and global DNA hypomethylation. Feeding the methyl-adequate diet restored the liver SAM levels and SAM/SAH ratios to control levels in all experimental groups. In contrast, re-feeding the complete diet restored DNA methylation to normal level only in the group that had been fed the methyl-deficient diet for 9 weeks; in animals exposed to methyl deprivation longer, the methyl-adequate diet failed to reverse the hypomethylation of DNA. Liver tissue of rats exposed to methyl deficiency for 9, 18, 24, or 36 weeks was characterized by the persistent presence of placental isoform of glutathione-S-transferase (GSTπ)-positive lesions despite re-feeding the methyl-adequate diet. The persistence of altered hepatic foci in liver after withdrawal of methyl-deficient diet serves as an indication of the carcinogenic potential of a methyl-deficient diet. Substitution of the methyl-deficient diet with complete diet failed to prevent the expansion of initiated foci and restore DNA methylation in animals exposed to deficiency for 18, 24, or 36 weeks. The association between DNA hypomethylation and expansion of foci suggests that stable DNA hypomethylation is a promoting factor for clonal expansion of initiated cells. These results provide an experimental evidence and a mechanistic basis by which epigenetic alterations may contribute to the initiation and promotion steps of carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLATION
KW - ADENOSYLMETHIONINE
KW - ADENOSINE
KW - GLUTATHIONE transferase
KW - TRANSFERASES
KW - CARCINOGENESIS
KW - DNA hypomethylation
KW - maintenance DNA methyltransferase ( DNMT1 )
KW - methyl-adequate ( MA )
KW - Methyl-adequate diet
KW - methyl-deficient ( MD )
KW - Methyl-deficient diet
KW - placental isoform of glutathione-S-transferase ( GSTπ )
KW - Rat hepatocarcinogenesis
KW - S-adenosylhomocysteine ( SAH )
KW - S-adenosylmethionine ( SAM )
N1 - Accession Number: 19471828; Pogribny, Igor P. 1; Email Address: ipogribny@nctr.fda.gov Ross, Sharon A. 2 Wise, Carolyn 1 Pogribna, Marta 1 Jones, Elisabeth A. 1 Tryndyak, Volodymyr P. 1 James, S. Jill 3 Dragan, Yvonne P. 1 Poirier, Lionel A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Dr., Jefferson, AR 72079, USA 2: National Cancer Institute, Bethesda, MD, USA 3: University of Arkansas for Medical Sciences, Little Rock, AR, USA; Source Info: Jan2006, Vol. 593 Issue 1/2, p80; Subject Term: METHYLATION; Subject Term: ADENOSYLMETHIONINE; Subject Term: ADENOSINE; Subject Term: GLUTATHIONE transferase; Subject Term: TRANSFERASES; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: DNA hypomethylation; Author-Supplied Keyword: maintenance DNA methyltransferase ( DNMT1 ); Author-Supplied Keyword: methyl-adequate ( MA ); Author-Supplied Keyword: Methyl-adequate diet; Author-Supplied Keyword: methyl-deficient ( MD ); Author-Supplied Keyword: Methyl-deficient diet; Author-Supplied Keyword: placental isoform of glutathione-S-transferase ( GSTπ ); Author-Supplied Keyword: Rat hepatocarcinogenesis; Author-Supplied Keyword: S-adenosylhomocysteine ( SAH ); Author-Supplied Keyword: S-adenosylmethionine ( SAM ); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2005.06.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wong-Chew, Rosa María
AU - Islas-Romero, Rocío
AU - García-García, María de Lourdes
AU - Beeler, Judy A.
AU - Audet, Susette
AU - Santos-Preciado, Jose Ignacio
AU - Gans, Hayley
AU - Lew-Yasukawa, Linda
AU - Maldonado, Yvonne A.
AU - Arvin, Ann M.
AU - Valdespino-Gómez, José Luis
T1 - Immunogenicity of aerosol measles vaccine given as the primary measles immunization to nine-month-old Mexican children
JO - Vaccine
JF - Vaccine
Y1 - 2006/01/30/
VL - 24
IS - 5
M3 - Article
SP - 683
EP - 690
SN - 0264410X
AB - Abstract: Aerosol measles vaccination has been found to be more immunogenic than subcutaneous administration as a booster in school aged children, and immunogenic in 12-month-old children as a primary dose. The objective of the study was to evaluate immunogenicity to aerosol measles vaccine in 9-month-old children. Methods: Nine-months-old infants received Edmonston-Zagreb measles vaccine by aerosol (103.58 CCID50/0.1mL, estimated retained dose 102.81 CCID50) or subcutaneous route (104.28 CCID50/0.5mL); cellular and humoral immunity and adverse events were assessed. Results: Measles-specific T cell proliferative responses developed in 42% of children given aerosolized vaccine compared with 67% of those who received subcutaneous vaccine (p =0.01); the mean stimulation index (SI) was 4.4±0.7 versus 6.9±1, respectively, (p =0.05). Seroconversion rates were 33 and 92% after aerosol or subcutaneous immunization (p <0.001). Among infants who developed serologic responses, measles geometric mean titers (GMT; 95% CI) by neutralizing antibody assay were 215mIU/mL (115–400) in aerosol vaccine recipients and 411mIU/mL (345–490) in those given subcutaneous vaccine (p =0.06). Conclusions: The proportion of 9-month-old infants who developed cellular and/or humoral immunity to measles was lower in the aerosol group but measles antibody and T cell responses were comparable among those who developed measles immunity. Differences in response rates are attributable to the lower aerosol dose. Improving aerosol delivery or increasing the dose may enhance immunogenicity of primary aerosol measles vaccination in this age group. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Immunization
KW - Immunization of children
KW - Preventive medicine
KW - Aerosol measles vaccine
KW - Cellular and humoral immunity
N1 - Accession Number: 19357412; Wong-Chew, Rosa María 1; Email Address: rmwong@correo.unam.mx; Islas-Romero, Rocío 2; García-García, María de Lourdes 2; Beeler, Judy A. 3; Audet, Susette 3; Santos-Preciado, Jose Ignacio 1,4; Gans, Hayley 5; Lew-Yasukawa, Linda 5; Maldonado, Yvonne A. 5; Arvin, Ann M. 5; Valdespino-Gómez, José Luis 2; Affiliations: 1: Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Dr. Balmis # 148, Colonia Doctores, 06726 Mexico City, México; 2: Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México; 3: Food and Drug Administration, Rockville, MD, USA; 4: Hospital Infantil de México Federico Gómez, México; 5: Stanford University School of Medicine, Stanford, CA, USA; Issue Info: Jan2006, Vol. 24 Issue 5, p683; Thesaurus Term: Vaccination; Thesaurus Term: Immunization; Subject Term: Immunization of children; Subject Term: Preventive medicine; Author-Supplied Keyword: Aerosol measles vaccine; Author-Supplied Keyword: Cellular and humoral immunity; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.08.045
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Toraason, Mark
AU - Lynch, Dennis W.
AU - DeBord, D. Gayle
AU - Singh, Narendra
AU - Krieg, Edward
AU - Butler, Mary Ann
AU - Toennis, Christine A.
AU - Nemhauser, Jeffrey B.
T1 - DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2006/01/31/
VL - 603
IS - 1
M3 - Article
SP - 1
EP - 14
SN - 13835718
AB - Abstract: 1-Bromopropane (1-BP; n-propyl bromide) (CAS No. 106-94-5) is an alternative to ozone-depleting chlorofluorocarbons that has a variety of potential applications as a degreasing agent for metals and electronics, and as a solvent vehicle for spray adhesives. Its isomer, 2-brompropane (2-BP; isopropyl bromide) (CAS No. 75-26-3) impairs antioxidant cellular defenses, enhances lipid peroxidation, and causes DNA damage in vitro. The present study had two aims. The first was to assess DNA damage in human leukocytes exposed in vitro to 1- or 2-BP. DNA damage was also assessed in peripheral leukocytes from workers with occupational exposure to 1-BP. In the latter assessment, start-of- and end-of-work week blood and urine samples were collected from 41 and 22 workers at two facilities where 1-BP was used as a solvent for spray adhesives in foam cushion fabrication. Exposure to 1-BP was assessed from personal-breathing zone samples collected for 1–3 days up to 8h per day for calculation of 8h time weighted average (TWA) 1-BP concentrations. Bromide (Br) was measured in blood and urine as a biomarker of exposure. Overall, 1-BP TWA concentrations ranged from 0.2 to 271 parts per million (ppm) at facility A, and from 4 to 27ppm at facility B. The highest exposures were to workers classified as sprayers. 1-BP TWA concentrations were statistically significantly correlated with blood and urine Br concentrations. The comet assay was used to estimate DNA damage. In vitro, 1- or 2-BP induced a statistically significant increase in DNA damage at 1mM. In 1-BP exposed workers, start-of- and end-of-workweek comet endpoints were stratified based on job classification. There were no significant differences in DNA damage in leukocytes between workers classified as sprayers (high 1-BP exposure) and those classified as non-sprayers (low 1-BP exposure). At the facility with the high exposures, comparison of end-of-week values with start-of-week values using paired analysis revealed non-sprayers had significantly increased comet tail moments, and sprayers had significantly increased comet tail moment dispersion coefficients. A multivariate analysis included combining the data sets from both facilities, log transformation of 1-BP exposure indices, and the use of multiple linear regression models for each combination of DNA damage and exposure indices including exposure quartiles. The covariates were gender, age, smoking status, facility, and glutathione S-transferase M1 and T1 (GSTM1, GSTT1) polymorphisms. In the regression models, start-of-week comet tail moment in leukocytes was significantly associated with serum Br quartiles. End-of-week comet tail moment was significantly associated with 1-BP TWA quartiles, and serum Br quartiles. Gender, facility, and GSTM1 had a significant effect in one or more models. Additional associations were not identified from assessment of dispersion coefficients. In vitro and in vivo results provide limited evidence that 1-BP exposure may pose a small risk for increasing DNA damage. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA damage
KW - Biochemical genetics
KW - Leucocytes
KW - Bromopropane
KW - Peroxidation
KW - Comet assay
KW - GSTM1
KW - GSTT1
KW - Humans
KW - Leukocytes
N1 - Accession Number: 19598946; Toraason, Mark 1; Email Address: mtoraason@cdc.gov; Lynch, Dennis W. 1; DeBord, D. Gayle 1; Singh, Narendra 2; Krieg, Edward 1; Butler, Mary Ann 1; Toennis, Christine A. 1; Nemhauser, Jeffrey B. 3; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; 2: University of Washington, Seattle, WA, USA; 3: National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA; Issue Info: Jan2006, Vol. 603 Issue 1, p1; Thesaurus Term: DNA damage; Subject Term: Biochemical genetics; Subject Term: Leucocytes; Subject Term: Bromopropane; Subject Term: Peroxidation; Author-Supplied Keyword: Comet assay; Author-Supplied Keyword: GSTM1; Author-Supplied Keyword: GSTT1; Author-Supplied Keyword: Humans; Author-Supplied Keyword: Leukocytes; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrgentox.2005.08.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106468692
T1 - Effects of treated and untreated depressive symptoms on highly active antiretroviral therapy use in a US multi-site cohort of HIV-positive women.
AU - Cook JA
AU - Grey D
AU - Burke-Miller J
AU - Cohen MH
AU - Anastos K
AU - Gandhi M
AU - Richardson J
AU - Wilson T
AU - Young M
Y1 - 2006/02//
N1 - Accession Number: 106468692. Language: English. Entry Date: 20060707. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Funded by the National Institute of Allergy and Infectious Diseases, the National Cancer Institute, the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Dental Research, and the Agency for Health Care Policy and Prevention: U01-AI-35004, U01-AI-31834, U01-AI-34994, AI-34989, U01-HD-32632 (NICHD), U01-AI-34993, U01-AI-42590, and N01-AI-35161. NLM UID: 8915313.
KW - Antiretroviral Therapy, Highly Active
KW - Depression -- Therapy
KW - HIV Seropositivity -- Drug Therapy
KW - HIV Seropositivity -- Psychosocial Factors
KW - Medication Compliance
KW - Blacks -- Psychosocial Factors
KW - CD4 Lymphocyte Count
KW - Center for Epidemiological Studies Depression Scale
KW - Combined Modality Therapy
KW - Counseling
KW - Descriptive Statistics
KW - Female
KW - Interviews
KW - Logistic Regression
KW - Multivariate Analysis
KW - P-Value
KW - Prospective Studies
KW - Psychological Tests
KW - Random Sample
KW - Scales
KW - Self Report
KW - United States
KW - Funding Source
KW - Human
SP - 93
EP - 100
JO - AIDS Care
JF - AIDS Care
JA - AIDS CARE
VL - 18
IS - 2
CY - Oxfordshire,
PB - Routledge
AB - This study examines the effects of treated and untreated depressive symptoms on the likelihood of utilization of highly active antiretroviral therapy (HAART) among a multi-site cohort of HIV-infected women who screened positive for probable depression. Data were collected biannually from 1996 through 2001 in a prospective cohort study. Random-effects regression analysis was used to estimate the longitudinal effects of mental health treatment on the probability of HAART utilization, controlling for clinical indicators (CD4 count, viral load), demographic features (race/ethnicity, income), and behavioural factors (recent crack, cocaine, or heroin use). Use of antidepressants plus mental health therapy, or use of mental health therapy alone significantly increased the probability of HAART utilization, compared to receiving no depression treatment. Use of antidepressants alone did not differ significantly from receiving no depression treatment. African American women and those who used crack, cocaine, or heroin also were less likely to use HAART. These findings suggest that efforts to enhance depressed women's access to psychopharmacologic treatment and therapy may increase their use of the most effective HIV therapies.
SN - 0954-0121
AD - Center for Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL 60603; cook@ripco.com
U2 - PMID: 16338766.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moy, Ernest
AU - Smith, Colleen Ryan
AU - Johansson, Patrik
AU - Andrews, Roxanne
T1 - GAPS IN DATA FOR AMERICAN INDIANS AND ALASKA NATIVES IN THE NATIONAL HEALTHCARE DISPARITIES REPORT.
JO - American Indian & Alaska Native Mental Health Research: The Journal of the National Center
JF - American Indian & Alaska Native Mental Health Research: The Journal of the National Center
Y1 - 2006/02//
VL - 13
IS - 1
M3 - Article
SP - 52
EP - 69
PB - University of Colorado Denver
SN - 15337731
AB - The aim of this study was to identify and quantify gaps in health care data for American Indians and Alaska Natives. Findings indicate that only 42% of measures of health care quality and access tracked in the National Healthcare Disparities Report could be used to assess disparities among American Indians and Alaska Natives. Patient safety data was especially limited. Data from American Indians and Alaska Natives need to be improved to allow better targeting of interventions to reduce health care disparities and monitoring the success of these activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Indian & Alaska Native Mental Health Research: The Journal of the National Center is the property of University of Colorado Denver and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - INDIGENOUS peoples
KW - NATIVE Americans
KW - ESKIMOS
KW - PATIENTS
N1 - Accession Number: 20500361; Moy, Ernest 1; Email Address: emoy@ahrq.gov Smith, Colleen Ryan Johansson, Patrik Andrews, Roxanne; Affiliation: 1: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; Source Info: 2006, Vol. 13 Issue 1, p52; Subject Term: MEDICAL care; Subject Term: INDIGENOUS peoples; Subject Term: NATIVE Americans; Subject Term: ESKIMOS; Subject Term: PATIENTS; Number of Pages: 18p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ming Ding
AU - Chuanshu Huang
AU - Yongju Lu
AU - Bowman, Linda
AU - Castranova, Vince
AU - Vallyathan, Vat
T1 - Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2006/02//
VL - 34
IS - 2
M3 - Article
SP - L291
EP - L297
SN - 10400605
AB - Crystalline silica has long been well established as a fibrogenic agent, and recent evidence has implicated it as a potential human carcinogen. However, the mechanisms of silica-induced disease development and progression are not well understood. Our previous studies demonstrated that crystalline silica is able to activate activator protein-I (AP-I) through mitogen-activated protein kinase (MAPK) pathways. The present study investigates the possible involvement of protein kinase C (PKC) in silica-induced activation of the MAPK/AP-1 signal transduction pathway. Treatment of mouse epidermal cells (JB6 cell line) with freshly fractured silica stimulated translocation of PKCα and PKCϵ from the cytosol to the membrane and activated AP-1 transcription activity. Pretreatment of cells with PKC inhibitors, including RO-32-0432, caiphostin C, and bisindolylmaleimide I, inhibited silica-induced AP-1 activation and phosphorylation of ERKs and p38 kinase. These inhibitory effects by PKC inhibitors were dose dependent. Furthermore, overexpression of dominant negative mutant (DNM) of PKCα or PKCϵ markedly blocked AP-1 activation as well as phosphorylation of ERKs and p38 kinase induced by freshly fractured silica. These results demonstrate that PKCα and PKCϵ are essential in silica-induced AP-1 activation through the MAP kinase (ERK5 and p38 kinases) pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENS
KW - LUNGS -- Cancer
KW - TRANSLOCATION (Genetics)
KW - CANCER genetics
KW - PROTEIN kinase C
KW - MITOGEN-activated protein kinases
KW - PHOSPHORYLATION
KW - activator protein- 1
KW - mitogen-activated protein kinase
KW - protein kinase C
KW - silica
N1 - Accession Number: 20009313; Ming Ding 1; Email Address: mid5@cdc.gov Chuanshu Huang 2 Yongju Lu 1 Bowman, Linda 1 Castranova, Vince 1 Vallyathan, Vat 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia. 2: Nelson Institute of Environmental Medicine, New York University, School of Medicine, Tuxedo, New York.; Source Info: Feb2006, Vol. 34 Issue 2, pL291; Subject Term: CARCINOGENS; Subject Term: LUNGS -- Cancer; Subject Term: TRANSLOCATION (Genetics); Subject Term: CANCER genetics; Subject Term: PROTEIN kinase C; Subject Term: MITOGEN-activated protein kinases; Subject Term: PHOSPHORYLATION; Author-Supplied Keyword: activator protein- 1; Author-Supplied Keyword: mitogen-activated protein kinase; Author-Supplied Keyword: protein kinase C; Author-Supplied Keyword: silica; Number of Pages: 7p; Document Type: Article
L3 - 10.1152/ajplung.00053.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Wong, ST;
AU - Kao, C;
AU - Crouch, JA;
AU - Korenbrot, CC;
T1 - Rural American Indian Medicaid health care services use and health care costs in California
CT - Rural American Indian Medicaid health care services use and health care costs in California
JO - American Journal of Public Health (USA)
JF - American Journal of Public Health (USA)
Y1 - 2006/02/01/
VL - 96
IS - Feb
SP - 363
EP - 370
SN - 00900036
AD - Calif Rural Indian Hlth Board, 4400 Auburn Blvd, 2nd Floor, Sacramento, CA 95841, USA carol.korenbrot@ihs.gov
N1 - Accession Number: 43-06554; Language: English; References: 26; Journal Coden: AJHEAA; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics
N2 - Objectives. We determined differences in Medicaid service use and health care costs in a rural Indian Health Service (IHS) user population of American Indians and Alaska Natives as compared with Whites. Methods. California Medicaid eligibility and claims files were linked to IHS user files to obtain a sample of Medicaid-eligible American Indian/Alaska Native users (n=7910). A random sample of Whites was matched for age, gender, aid category, length of eligibility, and county of residence (n=15075). We used generalized linear models to compare risk-adjusted use of resources-ambulatory visits, prescriptions, emergency room visits, hospitalizations, and costs-both adjusting and stratifying for dominant source of ambulatory visits. Results. American Indians/Alaska Natives had significantly lower use of Medicaid-paid ambulatory visits, prescriptions, emergency room visits, and hospitalizations and lower associated costs than Whites. Medicaid-paid total costs and use of services were lower for those who predominantly used Indian health program clinics, as well as for those who predominantly used other sources of ambulatory care. Conclusions. Barriers to receiving Medicaid services and payments exist for American Indians/Alaska Natives in the rural IHS-user population. If American Indians/Alaska Natives are to have Medicaid resources comparable to those of Whites, these barriers must be reduced.
KW - Health benefit programs--medicaid;
KW - Ethnic groups--indians, american;
KW - Health care--services;
KW - Costs--health care;
KW - Indians, American--ethnic groups;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Violanti, John M.
AU - Burchfiel, Cecil M.
AU - Miller, Diane B.
AU - Andrew, Michael E.
AU - Dorn, Joan
AU - Wactawski-Wende, Jean
AU - Beighley, Christopher M.
AU - Pierino, Kathleen
AU - Joseph, Parveen Nedra
AU - Vena, John E.
AU - Sharp, Dan S.
AU - Trevisan, Maurizio
T1 - The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Pilot Study: Methods and Participant Characteristics
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2006/02//
VL - 16
IS - 2
M3 - Article
SP - 148
EP - 156
SN - 10472797
AB - Purpose: The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study is one of the first population-based studies to integrate psychological, physiological, and subclinical measures of stress, disease, and mental dysfunction. This pilot study was undertaken to establish a methodology and descriptive results for a larger police study. Methods: A stratified sample of 100 officers was randomly selected from the Buffalo, NY Police Department. Salivary cortisol served as a stress biomarker. Flow mediated dilation (FMD) and carotid intima-media thickness (IMT) were performed with ultrasound. Dual Energy X-Ray Absorptiometry (DEXA) and anthropometric measures assessed body composition. Self-report measures of depression and posttraumatic stress disorder (PTSD) were obtained. Results: Recruitment attained for the study was 100%. Seventy-five percent showed a cortisol increase upon awakening, 90% a negative diurnal slope, and 77% an increased cortisol response after a high protein lunch challenge. Dexamethasone suppression was evident. FMD showed an increase in mean brachial artery diameter of 3.2% in men and 3.9% in women, and mean IMT was lower (male = 0.67 mm; female = 0.62 mm) compared to populations of similar age. For males, the mean body-mass index (BMI) was 29.8 kg/m2 and total body fat 23.4%. For females, the mean BMI was 26.7 kg/m2 and total body fat 31.5%. For all officers, 16% met criteria for depression; 36% reported elevated PTSD symptoms. Conclusions: Compared to populations of similar age, police officers had slightly lower FMD, lower carotid IMT, elevated BMI, and higher reported rates of depression and PTSD. Standardized physiological and psychological data collection and descriptive results confirmed that the methodology of the study is feasible in a working police population. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POST-traumatic stress disorder
KW - MENTAL depression
KW - POLICE -- Diseases
KW - HYDROCORTISONE
KW - body mass index ( BMI )
KW - brief symptom inventory ( BSI )
KW - Buffalo Cardio-Metabolic Occupational Police Stress study ( BCOPS )
KW - Cardiovascular Disease
KW - cardiovascular disease ( CVD )
KW - Center for Epidemiological Studies Depression scale ( CES—D )
KW - coronary heart disease ( CHD )
KW - Cortisol
KW - dual energy X-ray absorptiometry ( DEXA )
KW - flow mediated dilation ( FMD )
KW - hypothalamic—pituitary-adrenal system ( HPA )
KW - impact of event scale ( IES )
KW - intima-media thickness ( IMT )
KW - Police
KW - post traumatic stress disorder ( PTSD )
KW - Psychosocial Factors
KW - Risk Factors
KW - Stress
N1 - Accession Number: 19590815; Violanti, John M.; Email Address: violanti@buffalo.edu Burchfiel, Cecil M. 1 Miller, Diane B. 1 Andrew, Michael E. 1 Dorn, Joan 1 Wactawski-Wende, Jean 1 Beighley, Christopher M. 1 Pierino, Kathleen 1 Joseph, Parveen Nedra 1 Vena, John E. 1 Sharp, Dan S. 1 Trevisan, Maurizio 1; Affiliation: 1: From the School of Public Health and Health Professions, Department of Social and Preventive Medicine, State University of New York at Buffalo (J.M.V., J.D., J.W.-W., P.N.J.); Norman J. Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia (J.E.V.); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV (C.M.B., D.B.M., M.E.A., C.M.B., D.S.S.); Department of Criminal Justice, Hilbert College, Hamburg, NY (K.P.); and School of Public Health and Health Professions, Office of the Dean, State University of New York at Buffalo (M.T.); Source Info: Feb2006, Vol. 16 Issue 2, p148; Subject Term: POST-traumatic stress disorder; Subject Term: MENTAL depression; Subject Term: POLICE -- Diseases; Subject Term: HYDROCORTISONE; Author-Supplied Keyword: body mass index ( BMI ); Author-Supplied Keyword: brief symptom inventory ( BSI ); Author-Supplied Keyword: Buffalo Cardio-Metabolic Occupational Police Stress study ( BCOPS ); Author-Supplied Keyword: Cardiovascular Disease; Author-Supplied Keyword: cardiovascular disease ( CVD ); Author-Supplied Keyword: Center for Epidemiological Studies Depression scale ( CES—D ); Author-Supplied Keyword: coronary heart disease ( CHD ); Author-Supplied Keyword: Cortisol; Author-Supplied Keyword: dual energy X-ray absorptiometry ( DEXA ); Author-Supplied Keyword: flow mediated dilation ( FMD ); Author-Supplied Keyword: hypothalamic—pituitary-adrenal system ( HPA ); Author-Supplied Keyword: impact of event scale ( IES ); Author-Supplied Keyword: intima-media thickness ( IMT ); Author-Supplied Keyword: Police; Author-Supplied Keyword: post traumatic stress disorder ( PTSD ); Author-Supplied Keyword: Psychosocial Factors; Author-Supplied Keyword: Risk Factors; Author-Supplied Keyword: Stress; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 912130 Provincial police services; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 913130 Municipal police services; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.annepidem.2005.07.054
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seong-Jae Kim
AU - Ohgew Kweon
AU - Freeman, James P.
AU - Jones, Richard C.
AU - Adjei, Michael D.
AU - Jin-Woo Jhoo
AU - Edmondson, Ricky D.
AU - Cerniglia, Carl E.
T1 - Molecular Cloning and Expression of Genes Encoding a Novel Dioxygenase Involved in Low- and High-Molecular-Weight Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/02//
VL - 72
IS - 2
M3 - Article
SP - 1045
EP - 1054
SN - 00992240
AB - Mycobacterium vanbaalenii PYR-1 is able to metabolize a wide range of low- and high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). A 20-kDa protein was upregulated in PAH-metabolizing M. vanbaalenii PYR-1 cells compared to control cultures. The differentially expressed protein was identified as a β subunit of the terminal dioxygenase using mass spectrometry. PCR with degenerate primers designed based on de novo sequenced peptides and a series of plaque hybridizations were done to screen the M. vanbaalenii PYR-1 genomic library. The genes, designated nidA3B3, encoding the a and β subunits of terminal dioxygenase, were subsequently cloned and sequenced. The deduced enzyme revealed close similarities to the corresponding PAH ring-hydroxylating dioxygenases from Mycobacterium and Rhodococcus spp. but had the highest similarity, 61.9%, to the a subunit from Nocardioides sp. strain KP7. The a subunit also showed 52% sequence homology with the previously reported NidA from M. vanbaalenii PYR-1. The genes nidA3B3 were subcloned into the expression vector pET-17b, and the enzyme activity in Escherichia coli cells was reconstituted through coexpression with the ferredoxin (PhdC) and ferredoxin reductase (PhdD) genes of the phenanthrene dioxygenase from Nocardioides sp. strain KP7. The recombinant PAH dioxygenase appeared to favor the HMW PAH substrates fluoranthene, pyrene, and phenanthrene. Several other PAHs, including naphthalene, anthracene, and benz[a]anthracene, were also converted to their corresponding cis-dihydrodiols. The recombinant E. coli, however, did not show any dioxygenation activity for phthalate and biphenyl. The upregulation of nidA3B3 in M. vanbaalenii PYR-1 induced by PAHs was confirmed by reverse transcription-PCR analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR cloning
KW - POLYCYCLIC aromatic hydrocarbons
KW - GENE expression
KW - MYCOBACTERIUM
KW - MASS spectrometry
KW - POLYMERASE chain reaction
KW - GENE libraries
KW - PHENANTHRENE
KW - PYRENE (Chemical)
N1 - Accession Number: 20080102; Seong-Jae Kim 1 Ohgew Kweon 1 Freeman, James P. 2 Jones, Richard C. 3 Adjei, Michael D. 1 Jin-Woo Jhoo 4 Edmondson, Ricky D. 3 Cerniglia, Carl E. 1; Email Address: CCerniglia@nctr.fda.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research/U.S. FDA, Jefferson, Arkansas 72079. 2: Division of Biochemical Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, Arkansas 72079. 3: Division of Systems Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, Arkansas 72079. 4: Department of Food Science and Technology in Animal Resources, Kangwon National University, Chuncheon 200-701, Republic of Korea.; Source Info: Feb2006, Vol. 72 Issue 2, p1045; Subject Term: MOLECULAR cloning; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: GENE expression; Subject Term: MYCOBACTERIUM; Subject Term: MASS spectrometry; Subject Term: POLYMERASE chain reaction; Subject Term: GENE libraries; Subject Term: PHENANTHRENE; Subject Term: PYRENE (Chemical); Number of Pages: 10p; Document Type: Article
L3 - 10.1128/AEM.72.2.1045-1054.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sharma, Shashi K.
AU - Ferreira, Joseph. L.
AU - Eblen, Brian S.
AU - Whiting, Richard C.
T1 - Detection of Type A, B, E, and F Clostridium botulinum Neurotoxins in Foods by Using an Amplified Enzyme-Linked Immunosorbent Assay with Digoxigenin-Labeled Antibodies.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/02//
VL - 72
IS - 2
M3 - Article
SP - 1231
EP - 1238
SN - 00992240
AB - An amplified enzyme-linked immunosorbent assay (ELISA) for the detection of Clostridium botulinum complex neurotoxins was evaluated for its ability to detect these toxins in food. The assay was found to be suitable for detecting type A, B, E, and F botulinum neurotoxins in a variety of food matrices representing liquids, solid, and semisolid food. Specific foods included broccoli, orange juice, bottled water, cola soft drinks, vanilla extract, oregano, potato salad, apple juice, meat products, and dairy foods. The detection sensitivity of the test for these botulinum complex serotypes was found to be 60 pg/ml (1.9 50% lethal dose [LD50]) for botulinum neurotoxin type A (BoNT/A), 176 pg/ml (1.58 LD50) for BoNT/B, 163 pg/ml for BoNT/E (4.5 LD50), and 117 pg/ml for BoNT/F (less than 1 LD50) in casein buffer. The test could also readily detect 2 ng/ml of neurotoxins type A, B, E, and F in a variety of food samples. For specificity studies, the assay was also used to test a large panel of type A C. botulinum, a smaller panel of proteolytic and nonproteolytic type B, E, and F neurotoxin-producing Clostridia, and nontoxigenic organisms using an overnight incubation of toxin production medium. The assay appears to be an effective tool for large-scale screening of the food supply in the event of a botulinum neurotoxin contamination event. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - CLOSTRIDIUM botulinum
KW - NEUROTOXIC agents
KW - BOTTLED water
KW - FRUIT juices
KW - FOOD industry
KW - CLOSTRIDIUM
KW - DAIRY farms
KW - PRODUCE trade
N1 - Accession Number: 20080125; Sharma, Shashi K. 1; Email Address: shashi.sharma@cfsan.fda.gov Ferreira, Joseph. L. 2 Eblen, Brian S. 1 Whiting, Richard C. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety Applied Nutrition, College Park, Maryland 20740. 2: Centers for Disease Control and Prevention, Atlanta, Georgia.; Source Info: Feb2006, Vol. 72 Issue 2, p1231; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: CLOSTRIDIUM botulinum; Subject Term: NEUROTOXIC agents; Subject Term: BOTTLED water; Subject Term: FRUIT juices; Subject Term: FOOD industry; Subject Term: CLOSTRIDIUM; Subject Term: DAIRY farms; Subject Term: PRODUCE trade; NAICS/Industry Codes: 312110 Soft drink and ice manufacturing; NAICS/Industry Codes: 312112 Bottled Water Manufacturing; NAICS/Industry Codes: 413210 Non-alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311421 Fruit and Vegetable Canning; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; Number of Pages: 8p; Document Type: Article
L3 - 10.1128/AEM.72.2.1231-1238.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ham, Jason E.
AU - Proper, Steven P.
AU - Wells, J.R.
T1 - Gas-phase chemistry of citronellol with ozone and OH radical: Rate constants and products
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2006/02//
VL - 40
IS - 4
M3 - Article
SP - 726
EP - 735
SN - 13522310
AB - Abstract: A bimolecular rate constant, k OH+citronellol, of (170±43)×10−12 cm3 molecule−1 s−1 was measured using the relative rate technique for the reaction of the hydroxyl radical (OH) with 3,7-dimethyl-6-octen-1-ol (citronellol) at (297±3)K and 1 atmosphere total pressure. Additionally, a bimolecular rate constant, , of (2.4±0.1)×10−16 cm3 molecule−1 s−1, was measured by monitoring the decrease in ozone (O3) concentration in an excess of citronellol. To more clearly define part of citronellol''s indoor environment degradation mechanism, the products of the citronellol+OH and citronellol+O3 reactions were also investigated. The positively identified citronellol/OH and citronellol/O3 reaction products were: acetone, ethanedial (glyoxal, HC(lyph name="dbnd6" />O)H), and 2-oxopropanal (methylglyoxal, CH3C(lyph name="dbnd6" />O)H). The use of derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) were used to propose 6-hydroxy-4-methylhexanal as the other major citronellol/OH and citronellol/O3 reaction product. The elucidation of this other reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible citronellol/OH and citronellol/O3 reaction mechanisms based on previously published volatile organic compound/OH and volatile organic compound/O3 gas-phase reaction mechanisms. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Organic compounds
KW - Volatile organic compounds
KW - Mass spectrometry
KW - Spectrum analysis
KW - 3
KW - 3,7-dimethyl-6-octen-1-ol
KW - 7-dimethyl-6-octen-1-ol
KW - Citronellol
KW - Kinetics
KW - Oxygenated organic compounds
KW - Reaction products
N1 - Accession Number: 19340473; Ham, Jason E. 1; Proper, Steven P. 2; Wells, J.R. 1; Email Address: ozw0@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Department of Science and Mathematics, Environmental Chemistry, Kettering University, 1700 West Third Avenue, Flint, MI 48504, USA; Issue Info: Feb2006, Vol. 40 Issue 4, p726; Thesaurus Term: Organic compounds; Thesaurus Term: Volatile organic compounds; Thesaurus Term: Mass spectrometry; Thesaurus Term: Spectrum analysis; Author-Supplied Keyword: 3; Author-Supplied Keyword: 3,7-dimethyl-6-octen-1-ol; Author-Supplied Keyword: 7-dimethyl-6-octen-1-ol; Author-Supplied Keyword: Citronellol; Author-Supplied Keyword: Kinetics; Author-Supplied Keyword: Oxygenated organic compounds; Author-Supplied Keyword: Reaction products; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.atmosenv.2005.10.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wu, John Z.
AU - Cutlip, Robert G.
AU - Welcome, Daniel
AU - Dong, Ren G.
T1 - Estimation of the viscous properties of skin and subcutaneous tissue in uniaxial stress relaxation tests.
JO - Bio-Medical Materials & Engineering
JF - Bio-Medical Materials & Engineering
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Article
SP - 53
EP - 66
PB - IOS Press
SN - 09592989
AB - Knowledge of viscoelastic properties of soft tissues is essential for the finite element modelling of the stress/strain distributions in finger-pad during vibratory loading, which is important in exploring the mechanism of hand-arm vibration syndrome. In conventional procedures, skin and subcutaneous tissue have to be separated for testing the viscoelastic properties. In this study, a novel method has been proposed to simultaneously determine the viscoelastic properties of skin and subcutaneous tissue in uniaxial stress relaxation tests. A mathematical approach has been derived to obtain the creep and relaxation characteristics of skin and subcutaneous tissue using uniaxial stress relaxation data of skin/subcutaneous composite specimens. The micro-structures of collagen fiber networks in the soft tissue, which underline the tissue mechanical characteristics, will be intact in the proposed method. Therefore, the viscoelastic properties of soft tissues obtained using the proposed method would be more physiologically relevant than those obtained using the conventional method. The proposed approach has been utilized to measure the viscoelastic properties of soft tissues of pig. The relaxation curves of pig skin and subcutaneous tissue obtained in the current study agree well with those in literature. Using the proposed approach, reliable material properties of soft tissues can be obtained in a cost- and time-efficient manner, which simultaneously improves the physiological relevance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRATION syndrome
KW - FINGER diseases
KW - SKIN
KW - VISCOELASTICITY
KW - STRESS relaxation tests
KW - STRAIN (Physiology)
KW - creep
KW - relaxation
KW - skin
KW - Soft tissue
KW - subcutaneous
KW - viscoelastic
N1 - Accession Number: 19420931; Wu, John Z. 1; Email Address: jwu@cdc.gov. Cutlip, Robert G. 1 Welcome, Daniel 1 Dong, Ren G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: 2006, Vol. 16 Issue 1, p53; Subject Term: VIBRATION syndrome; Subject Term: FINGER diseases; Subject Term: SKIN; Subject Term: VISCOELASTICITY; Subject Term: STRESS relaxation tests; Subject Term: STRAIN (Physiology); Author-Supplied Keyword: creep; Author-Supplied Keyword: relaxation; Author-Supplied Keyword: skin; Author-Supplied Keyword: Soft tissue; Author-Supplied Keyword: subcutaneous; Author-Supplied Keyword: viscoelastic; Number of Pages: 14p; Illustrations: 3 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schultz, Kirk R.
AU - Miklos, David B.
AU - Fowler, Daniel
AU - Cooke, Ken
AU - Shizuru, Judith
AU - Zorn, Emmanuel
AU - Holler, Ernst
AU - Ferrara, James
AU - Shulman, Howard
AU - Lee, Stephanie J.
AU - Martin, Paul
AU - Filipovich, Alexandra H.
AU - Flowers, Mary E.D.
AU - Weisdorf, Daniel
AU - Couriel, Daniel
AU - Lachenbruch, Peter A.
AU - Mittleman, Barbara
AU - Vogelsang, Georgia B.
AU - Pavletic, Steven Z.
T1 - Toward Biomarkers for Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. Biomarker Working Group Report
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2006/02//
VL - 12
IS - 2
M3 - Article
SP - 126
EP - 137
SN - 10838791
AB - Abstract: Biology-based markers that can be used to confirm the diagnosis of chronic graft-versus-host disease (GVHD) or monitor progression of the disease could help in the evaluation of new therapies. Biomarkers have been defined as any characteristic that is objectively measured and evaluated as an indicator of a normal biologic or pathogenic process, a pharmacologic response to a therapeutic intervention, or a surrogate end point intended to substitute for a clinical end point. The following applications of biomarkers could be useful in chronic GVHD clinical trials or management: (1) predicting response to therapy; (2) measuring disease activity and distinguishing irreversible damage from continued disease activity; (3) predicting the risk of developing chronic GVHD; (4) diagnosing chronic GVHD: (5) predicting the prognosis of chronic GVHD; (6) evaluating the balance between GVHD and graft-versus-leukemia effects (graft-versus-leukemia or GVT); and (7) serving as a surrogate end point for therapeutic response. Such biomarkers can be identified by either hypothesis-driven testing or by high-throughput discovery-based methods. To date, no validated biomarkers have been established for chronic GVHD, although several candidate biomarkers have been identified from limited hypothesis-driven studies. Both approaches have merit and should be pursued. The consistent treatment and standardized documentation needed to support biomarker studies are most likely to be satisfied in prospective clinical trials. [Copyright &y& Elsevier]
AB - Copyright of Biology of Blood & Marrow Transplantation is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - GRAFT versus host disease
KW - DIAGNOSIS
KW - THERAPEUTICS
KW - CLINICAL trials
KW - LEUKEMIA
KW - Biomarkers
KW - Graft-versus-host disease
N1 - Accession Number: 19598657; Schultz, Kirk R. 1; Email Address: kschultz@interchange.ubc.ca Miklos, David B. 2 Fowler, Daniel 3 Cooke, Ken 4 Shizuru, Judith 2 Zorn, Emmanuel 5 Holler, Ernst 6 Ferrara, James 4 Shulman, Howard 7 Lee, Stephanie J. 8 Martin, Paul 7 Filipovich, Alexandra H. 9 Flowers, Mary E.D. 7 Weisdorf, Daniel 10 Couriel, Daniel 11 Lachenbruch, Peter A. 12 Mittleman, Barbara 13 Vogelsang, Georgia B. 14 Pavletic, Steven Z. 3; Affiliation: 1: British Columbia Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada 2: Stanford University Medical Center, Stanford, California 3: National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 4: University of Michigan Medical Center, Ann Arbor, Michigan 5: Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts 6: University of Regensburg, Regensburg, Germany 7: Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 8: Dana-Farber Cancer Institute, Boston, Massachusetts 9: Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 10: University of Minnesota, Minneapolis, Minnesota 11: M.D. Anderson Cancer Center, University of Texas, Houston, Texas 12: US Food and Drug Administration, Rockville, Maryland 13: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 14: Johns Hopkins University School of Medicine, Baltimore, Maryland; Source Info: Feb2006, Vol. 12 Issue 2, p126; Subject Term: BIOCHEMICAL markers; Subject Term: GRAFT versus host disease; Subject Term: DIAGNOSIS; Subject Term: THERAPEUTICS; Subject Term: CLINICAL trials; Subject Term: LEUKEMIA; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Graft-versus-host disease; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bbmt.2005.11.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gong-Ping Liu
AU - Qiang Ma
AU - Nian Shi
T1 - Tyrosine Hydroxylase as a Target for Deltamethrin in the Nigrostriatal Dopaminergic Pathway.
JO - Biomedical & Environmental Sciences
JF - Biomedical & Environmental Sciences
Y1 - 2006/02//
VL - 19
IS - 1
M3 - Article
SP - 27
EP - 34
SN - 08953988
AB - Objective To study the effects of deltamethrin on tyrosine hydroxylase in nigrostriatum of male rats. Methods Sprague-Dawley rats were daily treated with deltamethrin at 6.25 or 12.5 mg/kg body weight by gavage for 10 days. Then HPLC-fluorescence detection was used to analyze the contents of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homoranillic acid (HVA) in substantial nigra and striatum. The activities of tyrosine hydroxylase (TH) were also detected by HPLC-fluorescence detection. TH mRNA or TH protein levels were measured by RT-PCR and immunohistochemistry method. Results The content of DA in striatum was significantly decreased by the treatments, suggesting an inhibition of DA synthesis by deltamethrin. The contents of DA metabolites DOPAC and HVA increased, indicating increased dopamine turnover. Furthermore, deltamethrin significantly decreased the activity, as well as the mRNA and protein levels of TH. Conclusions These findings reveal a novel aspect of deltamethrin neurotoxicity and suggest tyrosine hydroxylase as a molecular target of deltamethin on dopamine metabolism in the nigrostriatal pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biomedical & Environmental Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Histochemistry
KW - Tyrosine
KW - Dopamine
KW - Substantia nigra
KW - Immunohistochemistry
KW - Biogenic amines
KW - Parkinson's disease
KW - Brain diseases
KW - Metabolism
KW - Deltamethrin
KW - Nigrostriatum
KW - Tyrosine hydroxylase
N1 - Accession Number: 20814500; Gong-Ping Liu 1; Qiang Ma 2; Nian Shi 1; Email Address: snian@mails.tjmu.edu.cn; Affiliations: 1: Department of Toxicology MOE key Laboratory of Environmental and Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China; 2: Receptor Biology Laboratory Toxicology and Molecular Biology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Morgantown WV 26505 USA; Issue Info: Feb2006, Vol. 19 Issue 1, p27; Thesaurus Term: Histochemistry; Subject Term: Tyrosine; Subject Term: Dopamine; Subject Term: Substantia nigra; Subject Term: Immunohistochemistry; Subject Term: Biogenic amines; Subject Term: Parkinson's disease; Subject Term: Brain diseases; Subject Term: Metabolism; Author-Supplied Keyword: Deltamethrin; Author-Supplied Keyword: Nigrostriatum; Author-Supplied Keyword: Tyrosine hydroxylase; Number of Pages: 8p; Illustrations: 4 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Eder, E.
AU - Wacker, M.
AU - Lutz, U.
AU - Nair, J.
AU - Fang, X.
AU - Bartsch, H.
AU - Beland, F.A.
AU - Schlatter, J.
AU - Lutz, W.K.
T1 - Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
Y1 - 2006/02//
VL - 159
IS - 2
M3 - Article
SP - 81
EP - 89
SN - 00092797
AB - Abstract: Both animal and epidemiological studies support an effect of fatty acid composition in the diet on cancer development, in particular on colon cancer. We investigated the modulating effect of supplementation of the diet of female F344 rats with sunflower-, rapeseed-, olive-, or coconut oil on the formation of the promutagenic, exocyclic DNA adducts in the liver, an organ where major metabolism of fatty acids takes place. 1,N 6-ethenodeoxyadenosine (etheno-dA), 3,N 4-ethenodeoxycytidine (etheno-dC) and 1,N 2-propandodeoxyguanosine from 4-hydroxy-2-nonenal (HNE-dGp) were determined as markers for DNA-damage derived from lipid peroxidation products and markers for oxidative stress. 8-Oxo-deoxyguanosine (8-Oxo-dG) was also measured as direct oxidative stress marker. The body weight of the rats was not influenced by the four diets containing the different vegetable oils during the 4-week feeding period. Highest adduct levels of etheno-dC (430±181 adducts/109 parent bases), HNE-dGp (617±96 adducts/109 parent bases) and 8-Oxo-dG (37,400±12,200 adducts/109 parent bases) were seen in rats on sunflower oil diet (highest linoleic acid content). Highest adducts levels of etheno-dA (133±113 adducts/109 parent bases) were found in coconut oil diet (lowest content of linoleic acid). Weakly positive correlations between linoleic acid content in the four diet groups were only observed for levels of HNE-dGp and 8-Oxo-dG. Neither the diet based on olive oil (which contains mainly oleic acid) nor the diet based on rapeseed oil (containing α-linolenic acid) exerted any significant protective effect against oxidative DNA damage. Our results indicate that a high linoleic acid diet may contribute to oxidative stress in the liver of female rats leading to a marginal increase in oxidative DNA-damage. [Copyright &y& Elsevier]
AB - Copyright of Chemico-Biological Interactions is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATIVE stress
KW - DNA
KW - GENES
KW - LIVER
KW - DNA adducts
KW - Fatty acids
KW - Oxidative stress
N1 - Accession Number: 19357115; Eder, E. 1; Email Address: eder@toxi.uni-wuerzburg.de Wacker, M. 1 Lutz, U. 1 Nair, J. 2 Fang, X. 2 Bartsch, H. 2 Beland, F.A. 3 Schlatter, J. 4 Lutz, W.K. 1; Affiliation: 1: Department of Toxicology, University of Würzburg, 97078 Würzburg, Germany 2: Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany 3: Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA 4: Swiss Federal Office of Public Health, Zürich, Switzerland; Source Info: Feb2006, Vol. 159 Issue 2, p81; Subject Term: OXIDATIVE stress; Subject Term: DNA; Subject Term: GENES; Subject Term: LIVER; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Oxidative stress; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.cbi.2005.09.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ijaz, Kashef
AU - Jereb, John A.
AU - Lambert, Lauren A.
AU - Bower, William A.
AU - Spradling, Philip R.
AU - McElroy, Peter D.
AU - Iademarco, Michael F.
AU - Navin, Thomas R.
AU - Castro, Kenneth G.
T1 - Severe or Fatal Liver Injury in 50 Patients in the United States Taking Rifampin and Pyrazinamide for Latent Tuberculosis Infection.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/02//2/1/2006
VL - 42
IS - 3
M3 - Article
SP - 346
EP - 355
SN - 10584838
AB - Background. Severe liver injuries were attributed to the rifampin and pyrazinamide (RZ) regimen after it was recommended for treating latent tuberculosis infection. Implicating RZ as the likeliest cause required excluding alternative causes. Methods. US health departments reported data on patients who died or were hospitalized for liver disease within 1 month after taking RZ for latent tuberculosis infection from October 1998 through March 2004. The circumstances were investigated on site for each case. Illness characteristics, reasons for RZ treatment, doses and frequency of administration of pyrazinamide, monitoring during treatment, and causes of liver injury were determined. Results. Liver injury was attributable to RZ use for all 50 patients reported, 12 of whom died. For 47 patients, RZ was the likeliest cause of liver injury. The median patient age was 44 years (range, 17-73 years). Thirty-two patients (64%) were male. Seven (16%) of 43 patients tested had hepatitis C virus antibodies, 1 (2%) of 45 had chronic hepatitis B, 3 (14%) of 22 had positive results of HIV serologic tests, 34 (71%) of 48 had alcohol use noted, and 33 (66%) of 50 were taking additional hepatotoxic medications. Six patients, 2 of whom died, had no predictors for liver disease. Patients who died were older (median age, 52 vs. 42 years; P = .08) and took a greater number of other medications (median number of medications, 4 vs. 2; P = .05) than did those who recovered, but these 2 factors were correlated (P<.01). Thirty-one patients (62%) were monitored according to guidelines, 9 of whom died. Conclusions. RZ was the likeliest cause of most of these liver injuries, some of which were fatal in spite of monitoring. Fatality was predicted by age or use of other medications, but none of the cofactors showed promise as a reliable clinical predictor of severe liver injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Infection
KW - Liver diseases
KW - Rifampin
KW - Therapeutics
KW - United States
N1 - Accession Number: 19451077; Ijaz, Kashef 1; Email Address: kijaz@cdc.gov; Jereb, John A. 1; Lambert, Lauren A. 1; Bower, William A. 2; Spradling, Philip R. 1; McElroy, Peter D. 1; Iademarco, Michael F. 1; Navin, Thomas R. 1; Castro, Kenneth G. 1; Affiliations: 1: Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, US Department of Health and Human Services, Atlanta, Georgia.; 2: Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia.; Issue Info: 2/1/2006, Vol. 42 Issue 3, p346; Thesaurus Term: Tuberculosis; Thesaurus Term: Infection; Subject Term: Liver diseases; Subject Term: Rifampin; Subject Term: Therapeutics; Subject: United States; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bennish, Michael L.
AU - Khan, Wasif A.
AU - Begum, Monira
AU - Bridges, Emily A.
AU - Ahmed, Sabeena
AU - Saha, Debasish
AU - Salam, Mohammad A.
AU - Acheson, David
AU - Ryan, Edward T.
T1 - Low Risk of Hemolytic Uremic Syndrome after Early Effective Antimicrobial Therapy for Shigella dysenteriae Type 1 Infection in Bangladesh.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/02//2/1/2006
VL - 42
IS - 3
M3 - Article
SP - 356
EP - 362
SN - 10584838
AB - Background. Hemolytic uremic syndrome (HUS) may complicate up to 15% of cases of Shiga toxin (Stx)-expressing enterohemorrhagic Escherichia coli (STEC) O157:H7 infections in children. Administration of anti-microbials has been reported to increase the risk of STEC-associated HUS by >10-fold, presumably by increasing the expression and release of Stx by dying STEC bacteria. Shigella dysenteriae type 1 also expresses Stx. However, the effect of antimicrobial therapy on Stx release and the risk of HUS in humans is unknown. Methods. We measured serial stool Stx concentrations before and after administration of antimicrobials in 20 children infected with S. dysenteriae type 1 who had frank dysentery of <72 h duration. We also reviewed the results of 7 shigellosis drug trials performed in Bangladesh during 1988-2000 to estimate the risk of HUS. In these studies, antimicrobials were administered within 96 h after the onset of dysentery. Results. Stx levels decreased in stool samples obtained from 17 of 20 children after administration of antimicrobial agents; none of the 20 children developed HUS. Of 378 individuals infected with S. dysenteriae type 1 who were enrolled in drug trials (128 adult men [age, 18-60 years] and 250 children [age, 6 months to 15 years]), 351 (93%) received an antimicrobial agent to which the S. dysenteriae organism was susceptible ⩽96 h after the onset of symptoms; HUS developed in 1 child. The risk of developing HUS was 0.0026 for all participants (95% confidence interval, <0.001 to 0.015) and was 0.004 for children (95% confidence interval, 0.001-0.022). Conclusion. In persons infected with S. dysenteriae type 1, early administration of effective antibiotics is associated with decreased Stx concentrations in stool and a low risk of developing HUS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Communicable diseases
KW - Hemolytic-uremic syndrome
KW - Shigellosis
KW - Verocytotoxins
KW - Bangladesh
N1 - Accession Number: 19451078; Bennish, Michael L. 1,2,3; Khan, Wasif A. 4; Begum, Monira 4; Bridges, Emily A. 5; Ahmed, Sabeena 4; Saha, Debasish 4; Salam, Mohammad A. 4; Acheson, David 2,6; Ryan, Edward T. 5,7,8; Email Address: etryan@partners.org; Affiliations: 1: Africa Centre for Health and Population Studies, Mtubatuba, South Africa.; 2: Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; 3: International Centre for Diarrhoeal Disease Research, International Centre for Health and Population Research, Dhaka, Bangladesh.; 4: Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Center, Harvard School of Public Health, Boston, Massachusetts.; 5: Tropical and Geographic Medicine Center, Division of Infectious Diseases, Massachusetts General Hospital, Harvard School of Public Health, Boston, Massachusetts.; 6: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland.; 7: Department of Medicine, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts.; 8: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts.; Issue Info: 2/1/2006, Vol. 42 Issue 3, p356; Thesaurus Term: Antibacterial agents; Thesaurus Term: Communicable diseases; Subject Term: Hemolytic-uremic syndrome; Subject Term: Shigellosis; Subject Term: Verocytotoxins; Subject: Bangladesh; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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ER -
TY - JOUR
AU - KREBS, CHRISTOPHER P.
T1 - INMATE FACTORS ASSOCIATED WITH HIV TRANSMISSION IN PRISON.
JO - Criminology & Public Policy
JF - Criminology & Public Policy
Y1 - 2006/02//
VL - 5
IS - 1
M3 - Article
SP - 113
EP - 135
SN - 15386473
AB - Research Summary: The prevalence of AIDS infection is approximately four times higher in state and Federal prisons than among the general U.S. population. It is also apparent that high-risk HIV transmission behaviors occur inside prison; however, data that validly document cases of HIV transmission in prison are rare. This study uses data from a large sample of state prison inmates and logistic regression to determine what inmate characteristics are associated with contracting HIV inside prison. Findings indicate that inmates who are nonwhite and younger and who have been convicted of sexual crimes and have served longer sentences are more likely to contract HIV inside prison. Policy Implications: Documenting that HIV is transmitted inside prisons justifies the need for additional research and effective prevention strategies. Modeling what types of inmates might be at risk for contracting HIV inside prison can help public and correctional health researchers and officials improve their current prevention practices and ultimately reduce or prevent HIV transmission both inside and outside prison. [ABSTRACT FROM AUTHOR]
AB - Copyright of Criminology & Public Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections -- Transmission
KW - CORRECTIONAL institutions
KW - PRISONERS
KW - INSTITUTIONALIZED persons
KW - PRISONS
KW - AIDS (Disease)
KW - SEX offenders
KW - AIDS
KW - Correctional Health
KW - HIV
KW - Jail
KW - Prison
N1 - Accession Number: 20583429; KREBS, CHRISTOPHER P. 1; Affiliation: 1: Senior Research Social Scientist at RTI International where he conducts studies on juvenile justice and delinquency; adult offender and inmate behavior; substance abuse policy, epidemiology, and treatment; and corrections. Dr. Krebs has led and worked on several projects for the National Institute of Justice (NIJ), Bureau of Justice Statistics (BJS), National Institute on Drug Abuse (NIDA), Centers for Disease Control and Prevention (CDC), and Substance Abuse and Mental Health Services Administration (SAMHSA). He has employed both quantitative and qualitative methods in his research and has extensive experience designing studies, developing survey instruments, analyzing data, and reporting findings.; Source Info: Feb2006, Vol. 5 Issue 1, p113; Subject Term: HIV infections -- Transmission; Subject Term: CORRECTIONAL institutions; Subject Term: PRISONERS; Subject Term: INSTITUTIONALIZED persons; Subject Term: PRISONS; Subject Term: AIDS (Disease); Subject Term: SEX offenders; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: Correctional Health; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Jail; Author-Supplied Keyword: Prison; NAICS/Industry Codes: 911220 Federal correctional services; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 23p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1745-9133.2006.00101.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Trost, Robert P.
T1 - TIRED TITANIUM: A FATIGUE‐BASED APPROACH TO AIRCRAFT INVENTORY MANAGEMENT AND ACQUISITION PLANNING.
JO - Defence & Peace Economics
JF - Defence & Peace Economics
Y1 - 2006/02//
VL - 17
IS - 1
M3 - Article
SP - 1
EP - 21
SN - 10242694
AB - Airframe fatigue has emerged as a primary determinant of tactical aircraft service life. To investigate the impact of various operational scenarios on airframe fatigue and aircraft stocks, we develop an econometric model of fatigue and arrest landing accumulation for US Naval aircraft. Model forecasts suggest that fatigue‐related attrition threatens to reduce inventories below the level needed to meet operational commitments before planned replacements are available. Changes to training regimes could mitigate the shortfall, but it is likely that acquisition schedules will have to be accelerated, or current service life extension programs expanded to maintain inventories in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Defence & Peace Economics is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INVENTORIES
KW - INVENTORY control
KW - ECONOMETRICS
KW - AIRPLANES
KW - TURNOVER (Business)
KW - WRITE-offs
KW - Acquisition planning
KW - Aircraft procurement
KW - Airframe fatigue
N1 - Accession Number: 19182659; Meyerhoefer, Chad D. 1 Trost, Robert P. 2; Email Address: Trost@gwu.edu; Affiliation: 1: Agency for Healthcare Research and Quality, CFACT/DSER, 540 Gaither Road, Rockville, MD 20850, USA 2: George Washington University, Department of Economics, 1922 F St., NW, Old Main, Room 208, Washington, DC 20052, USA; Source Info: Feb2006, Vol. 17 Issue 1, p1; Subject Term: INVENTORIES; Subject Term: INVENTORY control; Subject Term: ECONOMETRICS; Subject Term: AIRPLANES; Subject Term: TURNOVER (Business); Subject Term: WRITE-offs; Author-Supplied Keyword: Acquisition planning; Author-Supplied Keyword: Aircraft procurement; Author-Supplied Keyword: Airframe fatigue; NAICS/Industry Codes: 336411 Aircraft Manufacturing; NAICS/Industry Codes: 336410 Aerospace product and parts manufacturing; NAICS/Industry Codes: 561990 All Other Support Services; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; Number of Pages: 21p; Illustrations: 5 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/10242690500369298
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Trost, Robert P.
AD - Agency for Healthcare Research and Quality, Rockville, MD
AD - George Washington U
T1 - Tired Titanium: A Fatigue-Based Approach to Aircraft Inventory Management and Acquisition Planning
JO - Defence and Peace Economics
JF - Defence and Peace Economics
Y1 - 2006/02//
VL - 17
IS - 1
SP - 1
EP - 21
SN - 10430717
N1 - Accession Number: 0828407; Keywords: Management; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200604
N2 - Airframe fatigue has emerged as a primary determinant of tactical aircraft service life. To investigate the impact of various operational scenarios on airframe fatigue and aircraft stocks, we develop an econometric model of fatigue and arrest landing accumulation for US Naval aircraft. Model forecasts suggest that fatigue-related attrition threatens to reduce inventories below the level needed to meet operational commitments before planned replacements are available. Changes to training regimes could mitigate the shortfall, but it is likely that acquisition schedules will have to be accelerated, or current service life extension programs expanded to maintain inventories in the future.
KW - National Security and War H56
KW - National Government Expenditures and Related Policies: Procurement H57
KW - Production Management M11
L3 - http://www.tandfonline.com/loi/gdpe20
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UR - http://www.tandfonline.com/loi/gdpe20
DP - EBSCOhost
DB - ecn
ER -
TY -
AU - Jefferys, David1, David_Jefferys@eisai.net
AU - Atkins, David2
AU - Button, Andy3
AU - Gutman, Steven4
T1 - Pharmacogenomic Testing and Regulation: The Role of Pharmacogenomics in Pharmaceutical Development and the Regulation of Pharmacogenetic Test as In Vitro Diagnostics.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2006/02//
Y1 - 2006/02//
VL - 40
IS - 1
CP - 1
M3 - Article
SP - 7
EP - 13
SN - 00928615
AB - This article reviews the current role and future trends of pharmacogenomic testing in pharmaceutical development and postmarketing surveillance. The regulatory controls operating in Europe and the United States are described and compared. It is suggested that codevelopment of the diagnostic test should be considered as an integral part of the drug development program. The regulatory controls of the pharmacogenetic test and the drug need to be better aligned. Integration of patient and professional information is required. International standards are required for "traceability." [ABSTRACT FROM AUTHOR]
KW - Pharmacogenomics
KW - Drug development
KW - Biochemical genetics
KW - Pharmacology
KW - Combination products
KW - Conformity assessment
KW - In vitro diagnostics
KW - Pharmacogenetics
KW - Traceability
N1 - Accession Number: 20444646; Authors: Jefferys, David 1 Email Address: David_Jefferys@eisai.net; Atkins, David 2; Button, Andy 3; Gutman, Steven 4; Affiliations: 1: Senior Strategic Regulatory Advisor, Eisai Europe Ltd.; 2: Veridex, LLC, a Johnson and Johnson Company, Warren, New Jersey; 3: Director of External and Regulatory Affairs, Abbott Diagnostics, United Kingdom; 4: Director, Office of In Vitro Diagnostics, Center for Diseases and Radiological Health, Food and Drug Administration; Subject: Pharmacogenomics; Subject: Drug development; Subject: Biochemical genetics; Subject: Pharmacology; Author-Supplied Keyword: Combination products; Author-Supplied Keyword: Conformity assessment; Author-Supplied Keyword: In vitro diagnostics; Author-Supplied Keyword: Pharmacogenetics; Author-Supplied Keyword: Traceability; Number of Pages: 7p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Matlay, Joshua P.
AU - Powers, John H.
AU - Dudley, Michael N.
AU - Chriatiansen, Keryn
AU - Finch, Roger G.
T1 - Antimicrobial Drug Resistance, Regulation, and Research.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006/02//
VL - 12
IS - 2
M3 - Article
SP - 183
EP - 190
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Innovative regulatory and legislative measures to stimulate and facilitate the development of new antimicrobial drugs are needed. We discuss research approaches that can aid regulatory decision making on the treatment of resistant infections and minimization of resistance selection. We also outline current and future measures that regulatory agencies may employ to help control resistance and promote drug development. Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection. Internationally, variations exist in how regulators use drug scheduling, subsidy restrictions, central directives, educational guidelines, amendments to prescribing information, and indication review. Recent consultations and collaborations between regulators, academics, and industry are welcome. Efforts to coordinate regulatory measures would benefit from greater levels of international dialogue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Drug development
KW - Drug resistance in microorganisms
KW - Effect of drugs on microorganisms
KW - Pharmacokinetics
N1 - Accession Number: 19815018; Matlay, Joshua P. 1,2; Email Address: jmetlay@cceb.med.upenn.edu; Powers, John H. 3; Dudley, Michael N. 4; Chriatiansen, Keryn 5; Finch, Roger G. 6,7; Affiliations: 1: VA Medical Center, Philadelphia, Pennsylvania, USA; 2: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; 3: US Food and Drug Administration, Rockville, Maryland, USA; 4: Diversa Corporation, San Diego, California, USA; 5: Royal Perth Hospital, Perth, Western Australia, Australia; 6: Nottingham City Hospital, Nottingham, United Kingdom; 7: University of Nottingham, Nottingham, United Kingdom; Issue Info: Feb2006, Vol. 12 Issue 2, p183; Thesaurus Term: Anti-infective agents; Subject Term: Drug development; Subject Term: Drug resistance in microorganisms; Subject Term: Effect of drugs on microorganisms; Subject Term: Pharmacokinetics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Albers, Peter H.
AU - Klein, Patrice N.
AU - Green, David E.
AU - Melancon, Mark J.
AU - Bradley, Brian P.
AU - Noguchi, George
T1 - CHLORFENAPYR AND MALLARD DUCKS: OVERVIEW, STUDY DESIGN, MACROSCOPIC EFFECTS, AND ANALYTICAL CHEMISTRY.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2006/02//
VL - 25
IS - 2
M3 - Article
SP - 15
EP - 15
SN - 07307268
AB - The first commercial pesticide derived from a class of compounds known as halogenated pyrroles was registered for use in the United States in 2001. Chlorfenapyr degrades slowly in soil, sediment, and water and is highly toxic to birds. Information on biochemical or histological endpoints in birds is lacking; therefore, a two-year study was conducted to provide information needed to develop diagnostic criteria for chlorfenapyr toxicosis. In the first year, male mallard ducks were fed concentrations of 0, 2, 5, or 10 ppm technical chlorfenapyr or 5 ppm of a formulated product in their diet during a 10-week chronic exposure study. Survival, body weight, feed consumption (removal), behavior, and molt progression were monitored. Feed and liver were analyzed for chlorfenapyr and two metabolites. Five of 10 ducks in the 10-ppm group died, and neurotoxic effects were observed in the 5- and 10-ppm groups. Feed removal increased for ducks receiving chlorfenapyr and body weights of 5- and 10-ppm ducks were reduced. Loss of body fat, muscle atrophy, and bile retention were suggestive of metabolic disruption or a decreased ability to digest and absorb nutrients. Liver and kidney weights and liver and kidney weight/body weight ratios exhibited a positive response to concentrations of chlorfenapyr in the diet. Emaciation and elevated organ weight/body weight ratios are candidates for a suite of indicators of chronic chlorfenapyr exposure. Liver is the preferred tissue for chemical confirmation of exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES
KW - PYRROLES
KW - INSECTICIDES
KW - BIRDS
KW - METABOLITES
KW - Chlorfenapyr
KW - Chronic exposure
KW - Insecticide
KW - Mallard
KW - Toxic effects
N1 - Accession Number: 20488850; Albers, Peter H. 1 Klein, Patrice N. 2 Green, David E. 3 Melancon, Mark J. 1 Bradley, Brian P. 4 Noguchi, George 5; Affiliation: 1: U.S. Geological Survey Patuxent Wildlife Research Center, Beltsville Lab, c/o Beltsville Agricultural Research Center-East, Building 308, 10300 Baltimore Avenue, Beltsville, Maryland 20705 2: U.S. Public Health Service, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-366, College Park, Maryland 20740 3: U.S. Geological Survey National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711 4: University of Maryland-Baltimore County, Department of Biological Sciences, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA 5: U.S. Fish and Wildlife Service, Division of Environmental Quality, Arlington Square, 4401 North Fairfax Drive, Suite 322, Arlington, Virginia 22203; Source Info: Feb2006, Vol. 25 Issue 2, p15; Subject Term: PESTICIDES; Subject Term: PYRROLES; Subject Term: INSECTICIDES; Subject Term: BIRDS; Subject Term: METABOLITES; Author-Supplied Keyword: Chlorfenapyr; Author-Supplied Keyword: Chronic exposure; Author-Supplied Keyword: Insecticide; Author-Supplied Keyword: Mallard; Author-Supplied Keyword: Toxic effects; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 1p; Document Type: Article
L3 - 10.1897/05-004R.1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Páll, Gabriella
AU - Szövetes, Margit
AU - Márton, Hajnalka
AU - Molnár, Istvanné
AU - Vokó, Zoltán
AU - Szakos, Erzsébet
AU - Sipka, Sándor
AU - Ilyés, Istvan
AU - Szegedi, Gyula
AU - Pásti, Gabriella
T1 - Relation between the socioeconomic status of the family and primary allergy prevention in infant feeding in Hajdú-Bihar County, Hungary.
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Article
SP - 48
EP - 53
SN - 11011262
AB - Background: The relationship between socioeconomic status and preventive care is an important issue in public health practice in Hungary. Our aim was to investigate the association between the socioeconomic status and the present practice of primary allergy prevention in infant feeding in Hajdú-Bihar County, Hungary. Methods: A questionnaire-based cross-sectional survey was performed among 3076 infants aged 0-6 months. We studied how socioeconomic status, type of settlement, allergic background of the family and skin symptoms indicative for allergy were related to primary allergy prevention in infant feeding. Prevalence odds ratios (ORs) were calculated by multiple logistic regression. Results: Independent determinants of breast feeding were age [OR corresponding to one month change 0.74; 95% confidence interval (Cl) 0.70-0.77], the female gender (OR 1.24; 95% Cl 1.06-1.46), the socioeconomic status of the family (OR comparing the worst with the best category 0.63; 95% Cl 0.434.93), and birth weight (OR comparing <1500 g to >2500 g category 0.17; 95% Cl 0.07-0.41). Among supplementary nutrient users independent determinants of the use of hydrolysed infant formulae were the socioeconomic status (OR comparing the worst with the best category 0.06; 95% CI 0.01-0.27), the type of settlement (OR comparing village with town 0.48; 95% Cl 0.28-0.80), history of allergy in the family (OR 2.30; 95% Cl 1.28-4.11), and skin symptoms indicative of allergy (OR 3.46; 95% Ct 1.96-6.14). Conclusion: Socioeconomic status is related to the implementation of primary allergy prevention in infant feeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Public Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIOECONOMIC factors
KW - INFANT nutrition
KW - PUBLIC health
KW - ALLERGY
KW - HUNGARY
KW - infant nutrition
KW - primary prevention
KW - socio-economic factors
N1 - Accession Number: 20357377; Páll, Gabriella 1; Email Address: gabipall@ogyei.hu Szövetes, Margit 2 Márton, Hajnalka 3 Molnár, Istvanné 4 Vokó, Zoltán 5 Szakos, Erzsébet 6 Sipka, Sándor 6 Ilyés, Istvan 3 Szegedi, Gyula 6,7 Pásti, Gabriella 4; Affiliation: 1: National Institute of Child Health, Hungary 2: Primary Health Care Service of Debrecen, Hungary 3: Department of Family Medicine, Medical and Health Science Centre, University of Debrecen, Hungary 4: National Public Health Service, Hajdú-Bihar County, Hungary 5: School of Public Health. Medical and Health Science Centre, University of Debrecen, Hungary 6: 3rd Department of Internal Medicine, Medical and Health Science Centre, University of Debrecen, Hungary 7: Hungarian Academy of Sciences, University of Debrecen, Research Team of Autoimmune Diseases; Source Info: Feb2006, Vol. 16 Issue 1, p48; Subject Term: SOCIOECONOMIC factors; Subject Term: INFANT nutrition; Subject Term: PUBLIC health; Subject Term: ALLERGY; Subject Term: HUNGARY; Author-Supplied Keyword: infant nutrition; Author-Supplied Keyword: primary prevention; Author-Supplied Keyword: socio-economic factors; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/eurpub/cki067
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vidal-Alaball, J.
AU - Butler, C. C.
AU - Cannings-John, R.
T1 - Review: limited evidence from 2 randomised controlled trials suggests that oral and intramuscular vitamin B12 have similar effectiveness for vitamin B12 deficiency.
JO - Evidence Based Medicine
JF - Evidence Based Medicine
Y1 - 2006/02//
VL - 11
IS - 1
M3 - Article
SP - 9
EP - 9
SN - 13565524
AB - The article reports on the results of a review of various studies to determine the relative effectiveness of oral and intramuscular (IM) vitamin B12 for vitamin B12 deficiency. Randomized controlled trials which contrasted the two ways of administering the vitamin were evaluated. Findings indicated that large doses of oral and IM vitamin B12 have similar effectiveness.
KW - VITAMIN B12 deficiency
KW - VITAMIN B12 -- Therapeutic use
KW - INTRAMUSCULAR injections
KW - ORAL medication
KW - CLINICAL trials
KW - TREATMENT
N1 - Accession Number: 20000905; Vidal-Alaball, J. 1; Email Address: vidal-alaball@nphs.wales.nhs.uk Butler, C. C. Cannings-John, R.; Affiliation: 1: National Public Health Service for Wales, Wales, UK; Source Info: Feb2006, Vol. 11 Issue 1, p9; Subject Term: VITAMIN B12 deficiency; Subject Term: VITAMIN B12 -- Therapeutic use; Subject Term: INTRAMUSCULAR injections; Subject Term: ORAL medication; Subject Term: CLINICAL trials; Subject Term: TREATMENT; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meikle, Susan
AU - Orleans, Miriam
T1 - Safeguarding the quality and safety of reproductive services for human immunodeficiency virus–positive adults
JO - Fertility & Sterility
JF - Fertility & Sterility
Y1 - 2006/02//
VL - 85
IS - 2
M3 - Article
SP - 293
EP - 294
SN - 00150282
AB - Throughout the world, adults with HIV are living longer, and many are assessing their options for reproduction. The growing body of scientific evidence and commentary concerning the outcomes of infertility services provided to these adults demands systematic summary and long-term surveillance if safety, quality, and benefit are to be assured. [Copyright &y& Elsevier]
AB - Copyright of Fertility & Sterility is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - REPRODUCTIVE technology
KW - HUMAN fertility
KW - AIDS (Disease) in pregnancy
KW - INFERTILITY
KW - FERTILIZATION in vitro
N1 - Accession Number: 19619366; Meikle, Susan 1; Email Address: smeikle@ahrq.gov Orleans, Miriam 2; Affiliation: 1: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland 2: Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado; Source Info: Feb2006, Vol. 85 Issue 2, p293; Subject Term: HIV-positive persons; Subject Term: REPRODUCTIVE technology; Subject Term: HUMAN fertility; Subject Term: AIDS (Disease) in pregnancy; Subject Term: INFERTILITY; Subject Term: FERTILIZATION in vitro; NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.fertnstert.2005.07.1325
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collins, Thomas F.X.
AU - Sprando, Robert L.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Eppley, Robert M.
AU - Shackelford, Mary E.
AU - Howard, Paul C.
AU - Rorie, James I.
AU - Bryant, Mark
AU - Ruggles, Dennis I.
T1 - Effects of aminopentol on in utero development in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/02//
VL - 44
IS - 2
M3 - Article
SP - 161
EP - 169
SN - 02786915
AB - Abstract: Aminopentol (AP1), the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), is present in corn-based foods which are consumed daily as a substantial part of the diet in some areas of the world. The toxicity of FB1 has been attributed to altered sphingolipid metabolism, but the toxicity of AP1 is less certain. Epidemiological correlations and in vitro studies have suggested that AP1 can increase neural tube defects (NTDs), but no in vivo developmental study of AP1 was done prior to this study. AP1 was given once daily to rats by gavage on gestation days (GD) 3–16 at doses of 0, 15, 30, 60, or 120mg/kg. Reproductive and developmental parameters were measured at GD 17, one day after the last dose, and on GD 20. In addition, on GD 17, maternal and fetal tissues were analyzed for sphingolipid content. Conclusions: AP1 reduced dam body weight gain, but was less toxic than FB1. AP1 was not teratogenic, did not affect tissue sphingolipid ratios, did not alter reproduction or development of fetuses, and produced no dose-related histopathological effects in dams. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROLYSIS
KW - MYCOTOXINS
KW - FUMONISINS
KW - TOXICOLOGY
KW - NEURAL tube -- Abnormalities
KW - Aminopentol
KW - ANCOVA, analysis of covariance
KW - ANOVA, analysis of variance
KW - AP1, aminopentol
KW - Developmental toxicity
KW - FB1, fumonisin B1
KW - GD, gestation day
KW - Hydrolyzed fumonisin B1
KW - LSD, least significant difference
KW - Sa, sphinganine
KW - So, sphingosine
N1 - Accession Number: 19185889; Collins, Thomas F.X. 1; Email Address: tcollins@cfsan.fda.gov Sprando, Robert L. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Eppley, Robert M. 1 Shackelford, Mary E. 1 Howard, Paul C. 2 Rorie, James I. 1 Bryant, Mark 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Feb2006, Vol. 44 Issue 2, p161; Subject Term: HYDROLYSIS; Subject Term: MYCOTOXINS; Subject Term: FUMONISINS; Subject Term: TOXICOLOGY; Subject Term: NEURAL tube -- Abnormalities; Author-Supplied Keyword: Aminopentol; Author-Supplied Keyword: ANCOVA, analysis of covariance; Author-Supplied Keyword: ANOVA, analysis of variance; Author-Supplied Keyword: AP1, aminopentol; Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: FB1, fumonisin B1; Author-Supplied Keyword: GD, gestation day; Author-Supplied Keyword: Hydrolyzed fumonisin B1; Author-Supplied Keyword: LSD, least significant difference; Author-Supplied Keyword: Sa, sphinganine; Author-Supplied Keyword: So, sphingosine; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2005.06.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - D'Ovidio, Kathleen
AU - Trucksess, Mary
AU - Weaver, Carol
AU - Horn, Erin
AU - McIntosh, Marla
AU - Bean, George
T1 - Aflatoxins in ginseng roots.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2006/02//
VL - 23
IS - 2
M3 - Article
SP - 174
EP - 180
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Ginseng roots can be infected by molds during growth, harvest and storage and result in contamination with mycotoxins. In this study, an analytical method for the determination of aflatoxins B 1 , B 2 , G 1 and G 2 , a group of structurally similar mycotoxins, in ginseng root was developed. Test samples were extracted with methanol–water (8?+?2), diluted and passed through an immunoaffinity column packed with antibodies specific for aflatoxins. The purified extract was then derivatized with a mixture of water, trifluoroacetic acid and acetic acid. Aflatoxins were then separated and quantified by reverse phase liquid chromatography (LC) with fluorescence detection. Recoveries of total aflatoxins at 2, 4, 8 and 16?ng/g added to toxin-free 4 to 5-year old dried sliced Wisconsin ginseng were 92, 77, 91 and 83% respectively; and relative standard deviations were 3.6, 8.0, 6.9 and 2.0% respectively. A total of 11 wild simulated and 12 cultivated ginseng root samples were analysed for aflatoxins. All cultivated roots were found to be free of aflatoxin contamination. Two of the wild simulated roots contained total aflatoxins B 1 , B 2 , G 1 and G 2 at 15.1 and 15.2?ng/g. One moldy ginseng root purchased from a grocery store was found to be contaminated with aflatoxins at 16?ng/g. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Roots (Botany)
KW - Aflatoxins
KW - Mycotoxins
KW - Food additives
KW - Additives
KW - Pollutants
KW - Ginseng
KW - Fungal metabolites
KW - Microbial toxins
KW - ginseng root
KW - mycotoxins
N1 - Accession Number: 19540943; D'Ovidio, Kathleen 1; Trucksess, Mary 2; Email Address: mtruckse@cfsan.fda.gov; Weaver, Carol 2; Horn, Erin 1; McIntosh, Marla 1; Bean, George 1; Affiliations: 1: University of Maryland, College Park, Maryland; 2: U.S. Food and Drug Administration, College Park, Maryland; Issue Info: Feb2006, Vol. 23 Issue 2, p174; Thesaurus Term: Roots (Botany); Thesaurus Term: Aflatoxins; Thesaurus Term: Mycotoxins; Thesaurus Term: Food additives; Thesaurus Term: Additives; Thesaurus Term: Pollutants; Subject Term: Ginseng; Subject Term: Fungal metabolites; Subject Term: Microbial toxins; Author-Supplied Keyword: ginseng root; Author-Supplied Keyword: mycotoxins; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/02652030500442524
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Oelbermann, Maren
AU - Voroney, R. Paul
AU - Kass, Donald C.L.
AU - Schlönvoigt, Andrea M.
T1 - Soil carbon and nitrogen dynamics using stable isotopes in 19- and 10-year-old tropical agroforestry systems
JO - Geoderma
JF - Geoderma
Y1 - 2006/02//
VL - 130
IS - 3/4
M3 - Article
SP - 356
EP - 367
SN - 00167061
AB - Abstract: Conversion of forests to agricultural land in the American tropics, through traditional agricultural practices such as shifting cultivation, has not been able to maintain stocks of soil organic carbon (SOC), and increasing population pressure has led to shortened fallow periods, causing further losses of soil fertility. However, land management practices such as agroforestry can provide a sustainable alternative to single cropping because of its ability to maintain or increase the SOC pool. This study quantified SOC and nitrogen (N) pools, gross SOC turnover, residue stabilization efficiency (RSEAC) in the alley crop, soil δ 13C partitioning, C3-C abundance and δ 15N dynamics in 19- and 10-year Gliricidia sepium and Erythrina poeppigiana alley cropping system. Each system was studied at two fertilizer levels (tree prunings only [−N or −A], and tree prunings plus chicken manure [+N], or Arachis pintoi as a groundcover [+A]), and was compared to a sole crop system. The SOC and N pools were significantly higher (p <0.05) in the 19-year-old alley crop compared to the sole crop, but not significantly different (p <0.05) in the 10-year-old system. Soil C and N (%) showed a similar trend as that of the SOC and N pools in both 19- and 10-year-old systems. Gross SOC turnover, to a 20 cm depth, ranged from 12 to 21 years in the 19-year-old alley crop compared to 50 years in the sole crop, and from 20 to 32 years in the 10-year-old alley crop compared to 106 years in the sole crop. The RSEAC ranged from 10% to 58% in the 19-year-old system, and from 3% to 43% in the 10-year-old system. The δ 13C signature of the soil shifted significantly (p <0.05) towards that of C3 vegetation in the alley crop due to the greater input of organic residues from tree prunings compared to the sole crop. The proportion of input from tree prunings only in the 19-year-old alley crop ranged from 14% to 20%, and from 9% to 11% in the 10-year-old system to a soil depth of 20 cm. The δ 15N signature of the soil showed two patterns: that of the 19-year-old system being enriched in δ 15N, and that of the 10-year-old system being depleted in δ 15N compared to the sole crop. The addition of manure in the 19-year-old system has enriched the soil δ 15N and in the 10-year-old system the soil was depleted due to the N2-fixing groundcover A. pintoi. [Copyright &y& Elsevier]
AB - Copyright of Geoderma is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agroforestry
KW - Agricultural systems
KW - Soil fertility
KW - Agriculture -- Tropics
KW - Alley cropping
KW - Gross soil organic carbon turnover
KW - Ground cover
KW - Mulching
KW - Multipurpose tree species
KW - Residue stabilization efficiency
N1 - Accession Number: 19396907; Oelbermann, Maren 1; Email Address: moelberm@sciborg.uwaterloo.ca; Voroney, R. Paul 2; Kass, Donald C.L. 3; Schlönvoigt, Andrea M. 4; Affiliations: 1: Department of Earth Sciences, University of Waterloo, Waterloo, ON, Canada N2L 3G1; 2: Department of Land Resource Science, University of Guelph, Guelph, ON, Canada N1G 2W1; 3: Northeast Regional Laboratory, Food and Drug Administration, Department of Health and Human Services, 158-15 Liberty Avenue, Jamaica, NY 11433, United States; 4: GFA Terra Systems, Latin America Division, Eulenkrugstrasse 82, 22359 Hamburg, Germany; Issue Info: Feb2006, Vol. 130 Issue 3/4, p356; Thesaurus Term: Agroforestry; Thesaurus Term: Agricultural systems; Thesaurus Term: Soil fertility; Subject Term: Agriculture -- Tropics; Author-Supplied Keyword: Alley cropping; Author-Supplied Keyword: Gross soil organic carbon turnover; Author-Supplied Keyword: Ground cover; Author-Supplied Keyword: Mulching; Author-Supplied Keyword: Multipurpose tree species; Author-Supplied Keyword: Residue stabilization efficiency; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.geoderma.2005.02.009
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Park, J.-H.
AU - Schleiff, P. L.
AU - Attfield, M. D.
AU - Cox-Ganser, J. M.
AU - Kreiss, K.
T1 - Letter to the Editor.
JO - Indoor Air
JF - Indoor Air
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Letter
SP - 83
EP - 84
PB - Wiley-Blackwell
SN - 09056947
AB - A response by J.-H. Park, P. L. Schleiff, M. D. Attfield, J. M. Cox-Ganser and K. Kreiss to a letter to the editor about their article on building-related respiratory symptoms and their environmental exposure index in the December 2004 issue is presented.
KW - Letters to the editor
KW - Symptoms
N1 - Accession Number: 19411591; Park, J.-H. 1; Schleiff, P. L. 1; Attfield, M. D. 1; Cox-Ganser, J. M. 1; Kreiss, K. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV, USA; Issue Info: Feb2006, Vol. 16 Issue 1, p83; Subject Term: Letters to the editor; Subject Term: Symptoms; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1600-0668.2005.00400.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - van Wijk, P. Th.
AU - Pelk-Jongen, M.
AU - de Boer, E.
AU - Voss, A.
AU - Wijkmans, C.
AU - Schneeberger, P. M.
T1 - Differences between Hospital- and Community-Acquired Blood Exposure Incidents Revealed by a Regional Expert Counseling Center.
JO - Infection
JF - Infection
Y1 - 2006/02//
VL - 34
IS - 1
M3 - Article
SP - 17
EP - 21
SN - 03008126
AB - Objective: One year (2003) regional analysis of all blood exposure incidents from hospitals as well as from the community. Design: Establishment of an easily accessible regional expert counseling center, operating 24 h a day, for all accidental blood exposures. Tasks of the center were to register incoming calls, to inform and counsel the victim, to assess the risk of the incident, and to provide a plan of further actions, including prophylactic measures. Setting: A Dutch region (Northeast Brabant) with 500,000 inhabitants and two major hospitals (1,786 beds). Results: A total of 454 incidents (1.2 per day) were recorded. Only half of the incidents occurred in the hospital setting (n = 234), whereas the others (n = 220) took place in the community setting. Nearly all (95%, n = 432) incidents occurred during work, and most of them (84%, n = 385) were related to health care activities. In the hospital setting injuries occurred with physicians (13%), nursing staff (45%), operating room (OR) staff (13%), ancillary (18%), others (10%). In the community setting, incidents took place among healthcare workers (48%), detention and police officers (10%), civilians (10%), general practitioners/dentists and their staff (8%), cleaning staff (4%) and work-related incidents not falling into any of the above categories (7%). More low risk incidents took place outside the hospital (87% vs. 68% in hospital), while high-risk incidents predominantly occurred within the hospital setting (23% vs. 6%). The hepatitis-B immunization rate was significantly lower in victims from the community than in those working in hospitals (38% vs. 96%). Reports from incidents in the community setting were delayed. Conclusions: Incidents that expose individuals to blood-borne pathogens occur equally frequent in the hospital and non-hospital (community) setting. Therefore, a regional expert counseling center, accessible around-the-clock, for all types of blood-exposure incidents is needed. Blood-exposure prevention programs should aim at a reduction of high-risk incidents within hospitals, and at increasing the awareness for vaccination and early reporting within the community setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Infection is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Blood collection
KW - Community health services
KW - Medical errors
KW - Clinical sociology
KW - Medical care
N1 - Accession Number: 19870440; van Wijk, P. Th. 1; Pelk-Jongen, M. 1; de Boer, E. 2; Voss, A. 3,4; Wijkmans, C. 2; Schneeberger, P. M. 1; Email Address: p.schneeberger@jbz.nl; Affiliations: 1: Dept. of Medical Microbiology en Infection Control, Jeroen Bosch Hospital, POB 90153, 5211 ME, ‘s-Hertogenbosch, The Netherlands;; 2: Dept. of Infectious Diseases and Epidemiology, Public Health Service, Hart voor Brabant, ‘s-Hertogenbosch, The Netherlands; 3: Dept. of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; 4: Nijmegen University Centre for Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands; Issue Info: Feb2006, Vol. 34 Issue 1, p17; Thesaurus Term: Public health; Subject Term: Blood collection; Subject Term: Community health services; Subject Term: Medical errors; Subject Term: Clinical sociology; Subject Term: Medical care; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s15010-006-4125-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106366752
T1 - Differences between hospital- and community-acquired blood exposure incidents revealed by a regional expert counseling center.
AU - van Wijk PTL
AU - Pelk-Jongen M
AU - de Boer E
AU - Voss A
AU - Wijkmans C
AU - Schneeberger PM
Y1 - 2006/02//
N1 - Accession Number: 106366752. Language: English. Entry Date: 20061201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 0365307.
KW - Accidents, Occupational
KW - Bloodborne Pathogens
KW - Community-Acquired Infections -- Epidemiology
KW - Counseling
KW - Cross Infection -- Epidemiology
KW - Health Facilities
KW - Community-Acquired Infections -- Etiology
KW - Community-Acquired Infections -- Prevention and Control
KW - Cross Infection -- Etiology
KW - Cross Infection -- Prevention and Control
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Health Personnel
KW - Infection Control -- Methods
KW - Needlestick Injuries -- Epidemiology
KW - Netherlands
KW - Occupational Exposure
KW - Sample Size
KW - Time Factors
KW - Human
SP - 17
EP - 21
JO - Infection
JF - Infection
JA - INFECTION
VL - 34
IS - 1
CY - ,
PB - Springer Science & Business Media B.V.
AB - OBJECTIVE: One year (2003) regional analysis of all blood exposure incidents from hospitals as well as from the community. DESIGN: Establishment of an easily accessible regional expert counseling center, operating 24 h a day, for all accidental blood exposures. Tasks of the center were to register incoming calls, to inform and counsel the victim, to assess the risk of the incident, and to provide a plan of further actions, including prophylactic measures. SETTING: A Dutch region (Northeast Brabant) with 500,000 inhabitants and two major hospitals (1,786 beds). RESULTS: A total of 454 incidents (1.2 per day) were recorded. Only half of the incidents occurred in the hospital setting (n = 234), whereas the others (n = 220) took place in the community setting. Nearly all (95%, n = 432) incidents occurred during work, and most of them (84%, n = 385) were related to health care activities. In the hospital setting injuries occurred with physicians (13%), nursing staff (45%), operating room (OR) staff (13%), ancillary (18%), others (10%). In the community setting, incidents took place among healthcare workers (48%), detention and police officers (10%), civilians (10%), general practitioners/dentists and their staff (8%), cleaning staff (4%) and work-related incidents not falling into any of the above categories (7%). More low risk incidents took place outside the hospital (87% vs. 68% in hospital), while high-risk incidents predominantly occurred within the hospital setting (23% vs. 6%). The hepatitis-B immunization rate was significantly lower in victims from the community than in those working in hospitals (38% vs. 96%). Reports from incidents in the community setting were delayed. CONCLUSIONS: Incidents that expose individuals to blood-borne pathogens occur equally frequent in the hospital and non-hospital (community) setting. Therefore, a regional expert counseling center, accessible around-the-clock, for all types of blood-exposure incidents is needed. Blood-exposure prevention programs should aim at a reduction of high-risk incidents within hospitals, and at increasing the awareness for vaccination and early reporting within the community setting.
SN - 0300-8126
AD - Dept. of Infectious Diseases and Epidemiology, Public Health Service, Hart voor Brebant, 's-Hertogenbosch, The Netherlands
U2 - PMID: 16501897.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vladutiu, C. J.
AU - Nansel, T. R.
AU - Weaver, N. L.
AU - Jacobsen, H. A.
AU - Kreuter, M. W.
T1 - Differential strength of association of child injury prevention attitudes and beliefs on practices: a case for audience segmentation.
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
Y1 - 2006/02//
VL - 12
IS - 1
M3 - Article
SP - 35
EP - 40
SN - 13538047
AB - Objective: Many injuries to children cannot be prevented without some degree of active behavior on the part of parents. A better understanding of social and cognitive determinants of parents' injury prevention behavior and the identification of potential subgroups for targeted message delivery could advance the effectiveness of educational and behavioral interventions. This study assessed the degree to which parents' injury prevention behavior is associated with theoretical determinants and examined whether this relation differs by age or birth order of child. Design: Cross sectional observational study. Setting: Three Midwestern pediatric clinics. Subjects: 594 parents of children ages 0–4 attending routine well child visits. Measures: Injury prevention attitudes, beliefs, and practices. Results: Overall, only modest relations were observed between injury beliefs and attitudes and injury prevention behaviors. However, these relations differed substantially by child age and birth order, with stronger associations observed for parents of older first born children. Outcome expectations and social norms were more strongly related to injury prevention behavior among parents of preschool children than among parents of infants and toddlers, while attitudes were more predictive for parents of first born children than parents of later born children. Conclusions: These findings highlight the complexity of relations between theorized determinants and behavior, and suggest the potential utility of using audience segmentation strategies in behavioral interventions addressing injury prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Injury Prevention (1353-8047) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACCIDENT prevention
KW - SAFETY education
KW - CHILDREN -- Wounds & injuries
KW - HEALTH education
KW - COMMUNICATION in medicine
KW - CHILDREN'S accidents
N1 - Accession Number: 20098130; Vladutiu, C. J. 1; Email Address: cvladutiu@hrsa.gov Nansel, T. R. 2,3 Weaver, N. L. 4,5 Jacobsen, H. A. 4,5 Kreuter, M. W. 4,5; Affiliation: 1: Maternal and Child Health Bureau, United States Department of Health & Human Services 2: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health 3: Human Development, Department of Health and Human Services 4: Health Communication Research Laboratory, Saint Louis University 5: School of Public Health, Saint Louis University; Source Info: Feb2006, Vol. 12 Issue 1, p35; Subject Term: ACCIDENT prevention; Subject Term: SAFETY education; Subject Term: CHILDREN -- Wounds & injuries; Subject Term: HEALTH education; Subject Term: COMMUNICATION in medicine; Subject Term: CHILDREN'S accidents; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1136/ip.2004.007153
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106454428
T1 - Differential strength of association of child injury prevention attitudes and beliefs on practices: a case for audience segmentation.
AU - Vladutiu CJ
AU - Nansel TR
AU - Weaver NL
AU - Jacobsen HA
AU - Kreuter MW
Y1 - 2006/02//
N1 - Accession Number: 106454428. Language: English. Entry Date: 20060609. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 9510056.
KW - Wounds and Injuries -- Prevention and Control -- In Infancy and Childhood
KW - Parental Attitudes
KW - Socioeconomic Factors
KW - Health Promotion
KW - Birth Order
KW - Age Factors -- In Infancy and Childhood
KW - Child
KW - Child Health
KW - Child Safety
KW - Cross Sectional Studies
KW - Nonexperimental Studies
KW - Midwestern United States
KW - Adult
KW - Child, Preschool
KW - Infant
KW - Blacks
KW - Whites
KW - Scales
KW - Coefficient Alpha
KW - Internal Consistency
KW - Descriptive Statistics
KW - Regression
KW - Linear Regression
KW - Multiple Regression
KW - Human
SP - 35
EP - 40
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
JA - INJ PREV
VL - 12
IS - 1
PB - BMJ Publishing Group
AB - OBJECTIVE: Many injuries to children cannot be prevented without some degree of active behavior on the part of parents. A better understanding of social and cognitive determinants of parents' injury prevention behavior and the identification of potential subgroups for targeted message delivery could advance the effectiveness of educational and behavioral interventions. This study assessed the degree to which parents' injury prevention behavior is associated with theoretical determinants and examined whether this relation differs by age or birth order of child. DESIGN: Cross sectional observational study. SETTING: Three Midwestern pediatric clinics. SUBJECTS: 594 parents of children ages 0-4 attending routine well child visits. MEASURES: Injury prevention attitudes, beliefs, and practices. RESULTS: Overall, only modest relations were observed between injury beliefs and attitudes and injury prevention behaviors. However, these relations differed substantially by child age and birth order, with stronger associations observed for parents of older first born children. Outcome expectations and social norms were more strongly related to injury prevention behavior among parents of preschool children than among parents of infants and toddlers, while attitudes were more predictive for parents of first born children than parents of later born children. CONCLUSIONS: These findings highlight the complexity of relations between theorized determinants and behavior, and suggest the potential utility of using audience segmentation strategies in behavioral interventions addressing injury prevention.
SN - 1353-8047
AD - Maternal and Child Health Bureau, United States Department of Health & Human Services; cvladutiu@hrsa.gov
U2 - PMID: 16461418.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106453145
T1 - Research defines public dental health promotion in youth.
AU - van der Poel C
Y1 - 2006/02//
N1 - Accession Number: 106453145. Language: English. Entry Date: 20060609. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101168070.
KW - Dental Caries -- Epidemiology -- Netherlands
KW - Health Promotion -- Netherlands
KW - Public Health Dentistry -- Netherlands
KW - Child
KW - Dental Caries -- Epidemiology -- In Infancy and Childhood
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Netherlands
KW - Questionnaires
KW - Human
SP - 24
EP - 29
JO - International Journal of Dental Hygiene
JF - International Journal of Dental Hygiene
JA - INT J DENT HYG
VL - 4
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - In the Netherlands, Dental Public Health Service workers work in the healthcare delivery system to promote dental health. Since 1994, research has been conducted in Flevoland on the condition of children's teeth. This research has shaped the content of the dental health promotion directed at children in this region. The research comprises two parts: questionnaires for parents and children above the age of 12 and a dental examination of children aged 6 and 12 in the regional primary schools. The dental examination registers the health of the children's teeth. Sound teeth are defined as being free of visible caries and/or restoration. Not sound teeth show at least one case of visible caries and/or restoration. The research results have shown great dental differences between the various schools and between municipalities. The percentage of children with sound teeth ranges between 28 and 100 per school. Based on the final results of the research, an information pack will be disseminated. In the case of high-risk schools the dental health promotion will be conducted more intensively. The Dental Public Health Service workers will give information sessions to groups of parents and children, the dentist and the dental hygienist will provide individual information and prevention. At the child health clinic (consultatiebureau), education will be provided to parents of children ranging in age from 0 to 4. This combined approach has proven to be effective on a large majority of the children. To ensure uniform dental health promotion, information protocols are used in these promotion activities within Flevoland.
SN - 1601-5029
AD - Flevoland Public Health Service (GGD), PO Box 1120, 8200 BC Lelystad, The Netherlands; c.vanderpoel@hvdf.nl
U2 - PMID: 16451436.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - J. D. Tankson
AU - P. J. Fedorka-Cray
AU - C. R. Jackson
AU - M. Headrick
T1 - Genetic relatedness of a rarely isolated Salmonella: Salmonella enterica serotype Niakhar from NARMS animal isolates.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2006/02//
VL - 57
IS - 2
M3 - Article
SP - 190
EP - 198
SN - 03057453
N1 - Accession Number: 19575164; J. D. Tankson 1; P. J. Fedorka-Cray 1; C. R. Jackson 1; M. Headrick 2; Affiliations: 1: USDA/Agricultural Research Services, Bacterial and Epidemiology Antimicrobial Resistance Research Unit, 950 College Station Road, Athens, GA 30605, USA;; 2: US Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place HFV-200, Rockville, MD 20855, USA; Issue Info: Feb2006, Vol. 57 Issue 2, p190; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Elkins, Christopher A.
AU - Mullis, Lisa B.
T1 - Mammalian Steroid Hormones Are Substrates for the Major RND- and MFS-Type Tripartite Multidrug Efflux Pumps of Escherichia coli.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2006/02//
VL - 188
IS - 3
M3 - Article
SP - 36
EP - 36
SN - 00219193
AB - steroid-hormone-dependent growth suppression was observed in Escherichia coli efflux-deficient backgrounds containing mutations in the major RND- and MFS-type tripartite multidrug efflux systems, AcrAB-TolC and EmrAB-TolC, respectively. In addition to their previously known natural steroid spectrum, which includes bile acids, both systems were shown to transport the hormones estradiol and progesterone, whereas hydrocortisone served as a substrate of only AcrAB-TolC. Furthermore, at least two other RND-type pumps, YhiV and AcrD, were capable of transporting such hormones when overexpressed on plasmid vectors (with some demonstrable specificity observed with AcrD). When this activity was examined in a wild-type background, cell-associated estradiol levels remained largely unaffected by competition with exogenous bile acids and hydrocortisone, in contrast to progesterone, which produced a significant modulation in estradiol uptake [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - MUTATION (Biology)
KW - ESTRADIOL
KW - PROGESTERONE
KW - HYDROCORTISONE
KW - PLASMIDS
N1 - Accession Number: 20675424; Elkins, Christopher A. 1; Email Address: chris.elkins@fda.hhs.gov Mullis, Lisa B. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502; Source Info: Feb2006, Vol. 188 Issue 3, p36; Subject Term: ESCHERICHIA coli; Subject Term: MUTATION (Biology); Subject Term: ESTRADIOL; Subject Term: PROGESTERONE; Subject Term: HYDROCORTISONE; Subject Term: PLASMIDS; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.188.3.1191-1195.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hedayat, A. S.
AU - Yan, Xu
AU - Lin, Lawrence
T1 - Optimal Designs in Stability Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Article
SP - 35
EP - 59
PB - Taylor & Francis Ltd
SN - 10543406
AB - New optimality criteria for stability studies are proposed, and the related optimal designs are investigated. For each optimality criterion, optimal designs are identified within a class of competing designs. The property of the optimal designs for detecting slope differences is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPTIMAL designs (Statistics)
KW - EXPERIMENTAL design
KW - MATHEMATICAL optimization
KW - MATHEMATICAL analysis
KW - ANALYSIS of variance
KW - INDUSTRIAL design
KW - Bracketing Design
KW - Drug development
KW - Fractional factorial
KW - Information matrix
KW - Matrix design
KW - Optimality criterion
KW - Power
KW - Shelf life
KW - Stability studies
N1 - Accession Number: 19277322; Hedayat, A. S. 1 Yan, Xu 2 Lin, Lawrence 3; Affiliation: 1: Mathematics, Statistics and Computer Science Department, University of Illinois at Chicago, Chicago, Illinois, USA 2: Food and Drug Administration, Rockville, Maryland, USA 3: Baxter Healthcare Inc., Round Lake, Illinois, USA; Source Info: Feb2006, Vol. 16 Issue 1, p35; Subject Term: OPTIMAL designs (Statistics); Subject Term: EXPERIMENTAL design; Subject Term: MATHEMATICAL optimization; Subject Term: MATHEMATICAL analysis; Subject Term: ANALYSIS of variance; Subject Term: INDUSTRIAL design; Author-Supplied Keyword: Bracketing Design; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: Fractional factorial; Author-Supplied Keyword: Information matrix; Author-Supplied Keyword: Matrix design; Author-Supplied Keyword: Optimality criterion; Author-Supplied Keyword: Power; Author-Supplied Keyword: Shelf life; Author-Supplied Keyword: Stability studies; Number of Pages: 25p; Illustrations: 22 Charts; Document Type: Article
L3 - 10.1080/10543400500406512
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19277322&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holford, Nicholas
AU - Gobburu, Jogarao
T1 - Authors' Reply.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Article
SP - 125
EP - 126
PB - Taylor & Francis Ltd
SN - 10543406
AB - The article presents the authors' reply to the comments made on their article about terminal phase volume, published in a previous issue of the "Journal of Biopharmaceutical Statistics."
KW - VOLUMETRIC analysis
KW - BIOPHARMACEUTICS
N1 - Accession Number: 19277321; Holford, Nicholas 1 Gobburu, Jogarao 2; Affiliation: 1: University of Auckland, Auckland, New Zealand 2: Food and Drug Administration, Rockville, MD, 20852; Source Info: Feb2006, Vol. 16 Issue 1, p125; Subject Term: VOLUMETRIC analysis; Subject Term: BIOPHARMACEUTICS; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
L3 - 10.1080/10543400500406629
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murakami, Edgar G.
AU - Jackson, Lauren
AU - Madsen, Kevin
AU - Schickedanz, Brian
T1 - FACTORS AFFECTING THE ULTRAVIOLET INACTIVATION OF ESCHERICHIA COLI K12 IN APPLE JUICE AND A MODEL SYSTEM.
JO - Journal of Food Process Engineering
JF - Journal of Food Process Engineering
Y1 - 2006/02//
VL - 29
IS - 1
M3 - Article
SP - 53
EP - 71
SN - 01458876
AB - Ultraviolet (UV) light has been used successfully for years to sterilize water and was recently approved as an acceptable irradiation treatment for the processing of juice. Although there is considerable information on the efficacy of UV processing in the treatment of water, limited data are available on its efficacy in fluid food systems. The objectives of this work were to determine the effects of apple-juice properties on the UV inactivation of Escherichia coli K12 and the interdependence of intensity and time on the efficacy of UV light. Results showed that absorbance (A) and suspended solids (SS) affected UV inactivation, while pH and dissolved solids did not. Concerning the interdependence of intensity and time, intensity levels can only be changed without sacrificing effectiveness at a limited range of intensity and dose levels. This means that the range of the intensity level of the actual UV reactor must be considered in process-parameter determination. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Process Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTAMINATION (Technology)
KW - ULTRAVIOLET radiation
KW - STERILIZATION (Disinfection)
KW - IRRADIATION
KW - BACTERIOLOGY technique
KW - DISINFECTION & disinfectants
N1 - Accession Number: 19630386; Murakami, Edgar G. 1; Email Address: Edgar.Murakami@fda.hhs.gov; Jackson, Lauren 1; Madsen, Kevin 2; Schickedanz, Brian 2; Affiliations: 1: Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Ave., Summit-Argo, IL 60501; 2: Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 S. Archer Ave., Summit-Argo, IL 60501; Issue Info: Feb2006, Vol. 29 Issue 1, p53; Thesaurus Term: CONTAMINATION (Technology); Subject Term: ULTRAVIOLET radiation; Subject Term: STERILIZATION (Disinfection); Subject Term: IRRADIATION; Subject Term: BACTERIOLOGY technique; Subject Term: DISINFECTION & disinfectants; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 19p; Illustrations: 7 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1745-4530.2006.00049.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Yuhuan Chen
AU - Ross, William H.
AU - Gray, Michael J.
AU - Wiedmann, Martin
AU - Whiting, Richard C.
AU - Scott, Virginia N.
T1 - Attributing Risk to Listeria monocytogenes Subgroups: Dose Response in Relation to Genetic Lineages.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/02//
VL - 69
IS - 2
M3 - Article
SP - 335
EP - 344
SN - 0362028X
AB - The objective of this study was to evaluate the hypothesis that the dose-response relationship for Listeria monocytogenes in humans varies with genotypic lineage or subtype. The linkages between molecular subtyping data and enumeration data for L. monocytogenes subtypes in foods consumed by the at-risk population were examined to test this hypothesis. We applied a conditional probability model to conduct a subtype-specific dose-response analysis, with the focus on invasive listeriosis. L. monocytogenes differed not only in the molecular subtype and lineage but also in the contamination level when isolates of the pathogen occurred in retail samples of ready-to-eat foods. Using the exponential model parameter r-value as a measure (essentially the probability of a single cell causing illness), we found that the virulence varied among L. monocytogenes lineages by several orders of magnitude. Under the assumptions made, for L. monocytogenes lineages I and II the consumption of a single cell would result in listeriosis with log average probabilities of -7.88 (equivalent to once in 107.78 times) and -10.3, respectively, as compared with -9.72 for L. monocytogenes independent of subtype. A greater difference in r-values was found for selected ribotypes. The uncertainty about the r-value estimates was small compared with the large differences in the virulence parameters themselves. Thus, for L. monocytogenes both subtype and the number of cells consumed matter, highlighting the usefulness of considering both exposure concentration and subtype prevalence in dose-response analysis. As advances are made in molecular subtyping and quantitative tools for dose-response analysis, further studies integrating genomic data into quantitative risk assessments will enable better attribution of disease risk to L. monocytogenes subtypes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Listeria
KW - Food pathogens
KW - Gram-positive bacteria
KW - Pathogenic microorganisms
KW - Bacterial diseases
KW - Bacteriology
KW - Microorganisms
KW - Microbiology
KW - Listeria monocytogenes
KW - Listeriosis
N1 - Accession Number: 20064368; Yuhuan Chen 1; Email Address: ychen@fpa-food.org; Ross, William H. 2; Gray, Michael J. 3; Wiedmann, Martin 3; Whiting, Richard C. 4; Scott, Virginia N. 1; Affiliations: 1: Food Products Association, 1350 1 Street N. W., Suite 300, Washington, D.C. 20005, USA; 2: Bureau of Biostatistics and Computer Applications, Food Directorate, Health Canada, Tunney `s Pasture, Ottawa, Ontario, Canada KIA 0L2; 3: Department of Food Science, Cornell University, Ithaca, New York 14853, USA; 4: U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: Feb2006, Vol. 69 Issue 2, p335; Thesaurus Term: Listeria; Thesaurus Term: Food pathogens; Thesaurus Term: Gram-positive bacteria; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Bacterial diseases; Thesaurus Term: Bacteriology; Thesaurus Term: Microorganisms; Thesaurus Term: Microbiology; Subject Term: Listeria monocytogenes; Subject Term: Listeriosis; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grant, Michael A.
AU - Jinxin Ru
AU - Jinneman, Karen C.
T1 - Multiplex Real-Time PCR Detection of Heat-Labile and Heat- Stable Toxin Genes in Enterotoxigenic Escherichia coli.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/02//
VL - 69
IS - 2
M3 - Article
SP - 412
EP - 416
SN - 0362028X
AB - A multiplex real-time PCR method was developed for detection of heat-labile and heat-stable toxin genes in enterotoxigenic Escherichia coli. Approximately 10 CFU per reaction mixture could be detected in rinsates from produce samples. Several foods representative of varieties previously shown to have caused enterotoxigenic E. coli outbreaks were spiked and enriched for 4 or 6 h. Both heat-labile and heat-stable toxin genes could be detected in the foods tested, with the exception of hot sauce, with threshold cycle values ranging from 25.2 to 41.1. A procedure using membrane filtration which would allow enumeration of the enterotoxigenic E. coli population in a food sample in less than 28 h by real-time PCR analysis of colonies picked from media highly selective for E. coli was also developed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Escherichia
KW - Colonies (Biology)
KW - Bacteriology
KW - Microbiology
KW - Epidemics
KW - Polymerase chain reaction
KW - Polymerization
KW - Membrane separation
N1 - Accession Number: 20064378; Grant, Michael A. 1; Email Address: mike.grant@fda.gov; Jinxin Ru 2; Jinneman, Karen C. 3; Affiliations: 1: Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Borhell, Washington 98021; 2: Washington State Public Health Laboratory, 1610 N.E. 150th Street, Shoreline, Washington 98155, USA; 3: Seafood Products Research Center, U.S. Food and Drug Administration, 22201 23rd Drive S.E., Borhell, Washington 98021; Issue Info: Feb2006, Vol. 69 Issue 2, p412; Thesaurus Term: Escherichia coli; Thesaurus Term: Escherichia; Thesaurus Term: Colonies (Biology); Thesaurus Term: Bacteriology; Thesaurus Term: Microbiology; Thesaurus Term: Epidemics; Subject Term: Polymerase chain reaction; Subject Term: Polymerization; Subject Term: Membrane separation; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106414815
T1 - Preventable hospitalization and Medicaid managed care: does race matter?
AU - Basu J
AU - Friedman B
AU - Burstin H
Y1 - 2006/02//
N1 - Accession Number: 106414815. Language: English. Entry Date: 20060818. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 9103800.
KW - Hospitalization
KW - Managed Care Programs
KW - Medicaid
KW - Race Factors
KW - Adult
KW - Age Factors
KW - Blacks
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Female
KW - Funding Source
KW - Geographic Factors
KW - Health Services Accessibility
KW - Hispanics
KW - Inpatients
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Minority Groups
KW - New York
KW - Odds Ratio
KW - Outpatients
KW - Patient Admission
KW - Pennsylvania
KW - Urban Areas
KW - Whites
KW - Wisconsin
KW - Human
SP - 101
EP - 115
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 17
IS - 1
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - This study examines the preventable hospitalization patterns of Medicaid patients by race/ethnicity to determine whether Medicaid managed care (MMC) has been more effective in some subgroups than others. It uses logistic models for three states, comparing preventable hospitalizations with marker admissions (urgent admissions, insensitive to primary care). Hospital discharge data from the Healthcare Cost and Utilization Project State Inpatient database of the Agency for Health Care Research and Quality for New York, Pennsylvania, and Wisconsin residents aged 20-64 years is used. In a more urban state, New York, MMC was effective for Whites but not for minorities. In a more rural state, Wisconsin, MMC was effective for minorities. Overall, the evidence is not strong that any particular racial group consistently benefited from MMC, or that any state consistently showed a favorable impact of MMC across racial groups. However, racial/ethnic disparity associated with the risk of preventable hospitalization is significantly lower among Medicaid patients than among private fee-for-service patients.
SN - 1049-2089
AD - Senior Economist, Agency for Healthcare Research and Quality (AHRQ); Jbasu@ahrq.gov
U2 - PMID: 16520518.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yao, Karen
AU - Hisada, Michie
AU - Maloney, Elizabeth
AU - Yamano, Yoshihisa
AU - Hanchard, Barrie
AU - Wilks, Rainford
AU - Rios, Maria
AU - Jacobson, Steven
T1 - Human T Lymphotropic Virus Types I and II Western Blot Seroindeterminate Status and Its Association with Exposure to Prototype HTLV-I.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/02//2/1/2006
VL - 193
IS - 3
M3 - Article
SP - 427
EP - 437
SN - 00221899
AB - Human T lymphotropic virus types I and II (HTLV-I/II) Western blot (WB) seroindeterminate status, which is defined as an incomplete banding pattern of HTLV protein Gag (p19 or p24) or Env (GD21 or rgp46), is commonly observed. To investigate the significance of this finding, we examined HTLV-I/II serostatus and HTLV-I proviral load in 2 groups of individuals with WB seroindeterminate status. Low proviral loads were detected in 42% of patients with neurologic symptoms and 44% of voluntary blood donors. These data suggest that a subset of WB seroindeterminate individuals may be infected with prototype HTLV-I. To confirm this hypothesis, we evaluated HTLV-I/II serostatus and proviral load in prospectively collected specimens from 66 WB seronegative patients who had received HTLV-I-infected blood products by transfusion. Eight individuals developed WB seroindeterminate profiles after the transfusion. In addition, using a human leukocyte antigen type A*201-restricted HTLV-I Tax11-19 tetramer, we detected virus-specific CD8+ T cells in peripheral blood mononuclear cells from WB seroindeterminate patients. These CD8+ T cells were effective at targeting HTLV-I-infected cells. Collectively, the results suggest that HTLV-I/II WB seroindeterminate status may reflect a history of HTLV-I exposure. Our findings warrant further investigation of the possible clinical outcomes associated with WB seroindeterminate status. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - LYMPHOCYTES
KW - T cells
KW - PROTEINS
KW - BLOOD transfusion
KW - BLOOD donors
KW - WESTERN immunoblotting
N1 - Accession Number: 19452012; Yao, Karen 1,2 Hisada, Michie 3 Maloney, Elizabeth 3,4 Yamano, Yoshihisa 1,5 Hanchard, Barrie 6 Wilks, Rainford 6 Rios, Maria 7 Jacobson, Steven 1; Email Address: jacobsons@ninds.nih.gov; Affiliation: 1: Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda. 2: Department of Biology, Johns Hopkins University, Baltimore, Maryland. 3: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda. 4: Division of Viral and Rickettsial Diseases, Centers for Disease Prevention and Control, Atlanta, Georgia. 5: Third Department of Medicine, Kagoshima University School of Medicine, Kagoshima, Japan. 6: University of West Indies, Mona Kingston, Jamaica. 7: Food and Drug Administration, Rockville.; Source Info: 2/1/2006, Vol. 193 Issue 3, p427; Subject Term: VIRUSES; Subject Term: LYMPHOCYTES; Subject Term: T cells; Subject Term: PROTEINS; Subject Term: BLOOD transfusion; Subject Term: BLOOD donors; Subject Term: WESTERN immunoblotting; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sriram, Krishnan
AU - Miller, Diane B.
AU - O'Callaghan, James P.
T1 - Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-α.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2006/02//
VL - 96
IS - 3
M3 - Article
SP - 706
EP - 718
PB - Wiley-Blackwell
SN - 00223042
AB - Activated microglia are implicated in the pathogenesis of disease-, trauma- and toxicant-induced damage to the CNS, and strategies to modulate microglial activation are gaining impetus. A novel action of the tetracycline derivative minocycline is the ability to inhibit inflammation and free radical formation, factors that influence microglial activation. Minocycline is therefore being tested as a neuroprotective agent to alleviate CNS damage, although findings so far have yielded mixed results. Here, we showed that administration of a single low dose of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or methamphetamine (METH), a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in substantia nigra, increased the expression of mRNAs encoding microglia-associated factors F4/80, interleukin (IL)-1α, IL-6, monocyte chemoattractant protein-1 (MCP-1, CCL2) and tumor necrosis factor (TNF)-α. Minocycline treatment attenuated MPTP- or METH-mediated microglial activation, but failed to afford neuroprotection. Lack of neuroprotection was shown to be due to the inability of minocycline to abolish the induction of TNF-α and its receptors, thereby failing to modulate TNF signaling. Thus, TNF-α appeared to be an obligatory component of dopaminergic neurotoxicity. To address this possibility, we examined the effects of MPTP or METH in mice lacking genes encoding IL-6, CCL2 or TNF receptor (TNFR)1/2. Deficiency of either IL-6 or CCL2 did not alter MPTP neurotoxicity. However, deficiency of both TNFRs protected against the dopaminergic neurotoxicity of MPTP. Taken together, our findings suggest that attenuation of microglial activation is insufficient to modulate neurotoxicity as transient activation of microglia may suffice to initiate neurodegeneration. These findings support the hypothesis that TNF-α may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - PARKINSON'S disease
KW - CENTRAL nervous system -- Diseases
KW - MICROGLIA
KW - NEUROTOXICOLOGY
KW - NEUROLOGY
KW - brain
KW - microglia
KW - minocycline
KW - neurodegeneration
KW - neuroprotection
KW - Parkinson's disease
KW - tumor necrosis factor
N1 - Accession Number: 19427526; Sriram, Krishnan 1 Miller, Diane B. 1 O'Callaghan, James P. 1; Email Address: jdo5@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Feb2006, Vol. 96 Issue 3, p706; Subject Term: TUMOR necrosis factor; Subject Term: PARKINSON'S disease; Subject Term: CENTRAL nervous system -- Diseases; Subject Term: MICROGLIA; Subject Term: NEUROTOXICOLOGY; Subject Term: NEUROLOGY; Author-Supplied Keyword: brain; Author-Supplied Keyword: microglia; Author-Supplied Keyword: minocycline; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: neuroprotection; Author-Supplied Keyword: Parkinson's disease; Author-Supplied Keyword: tumor necrosis factor; Number of Pages: 13p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1111/j.1471-4159.2005.03566.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19427526&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vanderveen, John E.
T1 - Gap Analysis Guidelines for Assessing Acute, Chronic, and Lifetime Exposures to High Levels of Various Nutrients.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/02//
VL - 136
IS - 2
M3 - Article
SP - 514S
EP - 519S
SN - 00223166
AB - Twenty-two tolerable upper intake levels (ULs) have been established using data available from research with both humans and animals. No ULs were established for another 10 nutrients for which the existing data were evaluated. Gaps in knowledge on the adverse health effects that may arise as a result of acute, chronic, and lifetime exposures to high levels of many of these nutrients remain. The existence of a UL for a nutrient is not an indication that no gaps in the desired information exist, nor does the absence of a UL suggest that no risk of adverse health effects exists for very high levels of nutrient intake. Finally, it is important to keep in mind the definition of a UL. It is "the highest level of daily nutrient intake that is likely to pose no risk of adverse health effects for almost all individuals in the general population." There are many gaps in knowledge about the levels at which several nutrients cause adverse health effects. As these gaps are filled, the values for ULs will be adjusted as appropriate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REFERENCE values (Medicine)
KW - INGESTION
KW - TRACE elements in nutrition
KW - DISEASES -- Risk factors
KW - CLINICAL chemistry
KW - ABSORPTION (Physiology)
KW - NUTRITION
KW - TRACE elements
KW - PUBLIC health
KW - nutrient upper levels
KW - nutrition status
N1 - Accession Number: 19936003; Vanderveen, John E. 1; Email Address: jvanderv@cfsan.fda.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD.; Source Info: Feb2006, Vol. 136 Issue 2, p514S; Subject Term: REFERENCE values (Medicine); Subject Term: INGESTION; Subject Term: TRACE elements in nutrition; Subject Term: DISEASES -- Risk factors; Subject Term: CLINICAL chemistry; Subject Term: ABSORPTION (Physiology); Subject Term: NUTRITION; Subject Term: TRACE elements; Subject Term: PUBLIC health; Author-Supplied Keyword: nutrient upper levels; Author-Supplied Keyword: nutrition status; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hall, R. M.
AU - Earnest, S. G.
AU - Carroll, J. N.
AU - Spencer, A.
T1 - Evaluation of Carbon Monoxide Emissions from Engines on Recreational Boats Equipped with Prototype Catalysts.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/02//
VL - 3
IS - 2
M3 - Article
SP - D4
EP - D7
SN - 15459624
AB - The article reports on a study to evaluate carbon monoxide (CO) concentrations on and around two recreational boats equipped with prototype engines and catalyst, to help determine if this technology is a possible solution in controlling CO concentrations on recreational boats. Previous studies by the National Institute for Occupational Safety and Health (NIOSH) that about ninety percent of evaluated recreational boats produced potentially hazardous CO concentrations. Data collected during this study indicated CO concentrations below occupational exposure limits. Most of the average CO data indicated concentrations below health criteria relevant to the general public.
KW - CARBON monoxide
KW - EMISSIONS (Air pollution)
KW - BOATS & boating
KW - POISONOUS gases
KW - EMISSION exposure
KW - AIR pollution monitoring
KW - SAFETY
KW - AIR pollution
N1 - Accession Number: 19527065; Hall, R. M. 1 Earnest, S. G. 2 Carroll, J. N. 3 Spencer, A. 4; Affiliation: 1: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Engine, Emissions, and Vehicle Research Division, Southwest Research Institute, San Antonio, Texas 4: California Air Resources Board, Mobile Source Control Division, El Monte, California; Source Info: Feb2006, Vol. 3 Issue 2, pD4; Subject Term: CARBON monoxide; Subject Term: EMISSIONS (Air pollution); Subject Term: BOATS & boating; Subject Term: POISONOUS gases; Subject Term: EMISSION exposure; Subject Term: AIR pollution monitoring; Subject Term: SAFETY; Subject Term: AIR pollution; NAICS/Industry Codes: 423910 Sporting and Recreational Goods and Supplies Merchant Wholesalers; NAICS/Industry Codes: 441220 Motorcycle, boat and other motor vehicle dealers; NAICS/Industry Codes: 441222 Boat Dealers; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; NAICS/Industry Codes: 336612 Boat Building; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19527065&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lentz, T. J.
AU - Wenzl, T. B.
T1 - Small Businesses with High Fatality Rates: Assessment of Hazards and Their Prevention.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/02//
VL - 3
IS - 2
M3 - Article
SP - D8
EP - D14
SN - 15459624
AB - The article presents a study of small U.S. businesses with high fatality rates. A majority of the American workforce is employed in business establishments with fewer than 100 workers. Workplace fatality rates are often higher in those industries dominated by small workplaces. Similar patterns exist in the European Union. Prevention of occupational illness and injury is often difficult in small business establishments. This is because they typically have fewer safety and health resources, and often lack the ability to identify occupational hazards and conduct surveillance. Given these premises, this investigation was conducted with three objectives.
KW - WORK environment
KW - SMALL business
KW - OCCUPATIONAL mortality
KW - INDUSTRIAL safety
KW - SAFETY
KW - WORK-related injuries
KW - MORTALITY
KW - UNITED States
N1 - Accession Number: 19529845; Lentz, T. J. 1 Wenzl, T. B. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: University of Cincinnati, Department of Environmental Health, Cincinnati, Ohio; Source Info: Feb2006, Vol. 3 Issue 2, pD8; Subject Term: WORK environment; Subject Term: SMALL business; Subject Term: OCCUPATIONAL mortality; Subject Term: INDUSTRIAL safety; Subject Term: SAFETY; Subject Term: WORK-related injuries; Subject Term: MORTALITY; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106418453
T1 - Case study. Evaluation of carbon monoxide emissions from engines on recreational boats equipped with prototype catalysts.
AU - Hall RM
AU - Earnest SG
AU - Carroll JN
AU - Spencer A
A2 - Mazzuckelli LF
Y1 - 2006/02//
N1 - Accession Number: 106418453. Language: English. Entry Date: 20060331. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Carbon Monoxide
KW - Ships
KW - Arizona
KW - Case Studies
KW - Environmental Exposure
KW - National Institute for Occupational Safety and Health
KW - Nevada
KW - North Carolina
KW - Human
SP - D4
EP - 7
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16396826.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106418453&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106418452
T1 - Surveillance. Small businesses with high fatality rates: assessment of hazards and their prevention.
AU - Lentz TJ
AU - Wenzl TB
A2 - Greife A
Y1 - 2006/02//
N1 - Accession Number: 106418452. Language: English. Entry Date: 20060331. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Mortality -- Evaluation
KW - Occupational Safety -- Prevention and Control
KW - Construction Industry
KW - National Institute for Occupational Safety and Health
KW - Human
SP - D8
EP - 14
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16396827.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106418452&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kanwal, Richard
AU - Kullman, Greg
AU - Piacitelli, Chris
AU - Boylstein, Randy
AU - Sahakian, Nancy
AU - Martin, Stephen
AU - Fedan, Kathleen
AU - Kreiss, Kathleen
T1 - Evaluation of Flavorings-Related Lung Disease Risk at Six Microwave Popcorn Plants.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/02//
VL - 48
IS - 2
M3 - Article
SP - 149
EP - 157
SN - 10762752
AB - Objective: After investigating fixed airways obstruction in butter flavoring-exposed workers at a microwave popcorn plant, we sought to further characterize lung disease risk from airborne butter-flavoring chemicals. Methods: We analyzed data from medical and environmental surveys at six microwave popcorn plants (including the index plant). Results: Respiratory symptom and airways obstruction prevalences were higher in oil and flavorings mixers with longer work histories and in packaging-area workers near nonisolated tanks of oil and flavorings. Workers were affected at five plants, one with mixing-area exposure to diacetyl (a butter-flavoring chemical with known respiratory toxicity potential) as low as 0.02 ppm. Conclusions: Microwave popcorn workers at many plants are at risk for flavoring-related lung disease. Peak exposures may be hazardous even when ventilation maintains low average exposures. Respiratory protection and engineering controls are necessary to protect workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - INDUSTRIAL workers
KW - FLAVORING essences
KW - POPCORN
KW - EDIBLE fats & oils
KW - FOOD -- Packaging
KW - TOXICITY testing
KW - INDUSTRIAL safety
KW - PERSONNEL management
N1 - Accession Number: 20191683; Kanwal, Richard 1; Email Address: rkanwal@cdc.gov Kullman, Greg 1 Piacitelli, Chris 1 Boylstein, Randy 1 Sahakian, Nancy 1 Martin, Stephen 1 Fedan, Kathleen 1 Kreiss, Kathleen 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Source Info: Feb2006, Vol. 48 Issue 2, p149; Subject Term: RESPIRATORY diseases; Subject Term: INDUSTRIAL workers; Subject Term: FLAVORING essences; Subject Term: POPCORN; Subject Term: EDIBLE fats & oils; Subject Term: FOOD -- Packaging; Subject Term: TOXICITY testing; Subject Term: INDUSTRIAL safety; Subject Term: PERSONNEL management; NAICS/Industry Codes: 311930 Flavoring Syrup and Concentrate Manufacturing; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; Number of Pages: 9p; Illustrations: 6 Charts, 4 Graphs; Document Type: Article
L3 - 10.1097/01.jom.0000194152.48728.fb
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20191683&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stanton, Marcia L.
AU - Henneberger, Paul K.
AU - Kent, Michael S.
AU - Deubner, David C.
AU - Kreiss, Kathleen
AU - Schuler, Christine R.
T1 - Sensitization and Chronic Beryllium Disease Among Workers in Copper-Beryllium Distribution Centers.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/02//
VL - 48
IS - 2
M3 - Article
SP - 204
EP - 211
SN - 10762752
AB - Objective: Little is known about the risk of sensitization and chronic beryllium disease ( CBD) among workers performing limited processing of copper-beryllium alloys downstream of the primary beryllium industry. In this study, we performed a cross-sectional survey of employees at three copper-beryllium alloy distribution centers. Methods: One hundred workers were invited to be tested for beryllium sensitization using the beryllium blood lymphocyte proliferation test (BeLPT); a sensitized worker was further evaluated for CBD. Available beryllium mass concentration air sampling data were obtained for characterization of airborne exposure. Results: One participant, who had exposure to other forms of beryllium, was found to be sensitized and to have CBD, resulting in a prevalence of sensitization/CBD of 1% for all tested. Conclusions: The overall prevalence of beryllium sensitization and CBD for workers in these three copper-beryllium alloy distribution centers is lower than for workers in primary beryllium production facilities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BERYLLIUM industry
KW - INDUSTRIAL hygiene
KW - MEDICAL screening
KW - TRANSFER factor (Immunology)
KW - ALKALINE earth metals
KW - HAZARDOUS substances
KW - PERSONNEL management
KW - WAREHOUSES
KW - CHRONIC diseases
N1 - Accession Number: 20191690; Stanton, Marcia L. 1; Email Address: mstanton@cdc.gov Henneberger, Paul K. 1 Kent, Michael S. 2 Deubner, David C. 2 Kreiss, Kathleen 1 Schuler, Christine R. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 2: Brush Wellman Inc., Elmore, Ohio; Source Info: Feb2006, Vol. 48 Issue 2, p204; Subject Term: BERYLLIUM industry; Subject Term: INDUSTRIAL hygiene; Subject Term: MEDICAL screening; Subject Term: TRANSFER factor (Immunology); Subject Term: ALKALINE earth metals; Subject Term: HAZARDOUS substances; Subject Term: PERSONNEL management; Subject Term: WAREHOUSES; Subject Term: CHRONIC diseases; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 493110 General Warehousing and Storage; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 493190 Other Warehousing and Storage; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1097/01.jom.0000184864.10147.bc
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20191690&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106461582
T1 - Evaluation of flavorings-related lung disease risk at six microwave popcorn plants.
AU - Kanwal R
AU - Kullman G
AU - Piacitelli C
AU - Boylstein R
AU - Sahakian N
AU - Martin S
AU - Fedan K
AU - Kreiss K
Y1 - 2006/02//
N1 - Accession Number: 106461582. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Institute for Occupational Safety and Health. NLM UID: 9504688.
KW - Air Pollutants, Occupational -- Analysis
KW - Flavoring Agents -- Adverse Effects
KW - Lung Diseases, Obstructive -- Prevention and Control
KW - Occupational Exposure -- Analysis
KW - Adolescence
KW - Adult
KW - Aged
KW - Air Pollutants, Occupational -- Adverse Effects
KW - Chi Square Test
KW - Corn
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Interviews
KW - Lung Diseases, Obstructive -- Chemically Induced
KW - Lung Diseases, Obstructive -- Epidemiology
KW - Male
KW - Middle Age
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Exposure -- Prevention and Control
KW - Occupations and Professions
KW - P-Value
KW - Questionnaires
KW - Risk Assessment
KW - Self Report
KW - Spirometry
KW - Survey Research
KW - Surveys
KW - T-Tests
KW - United States
KW - Human
SP - 149
EP - 157
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 48
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: After investigating fixed airways obstruction in butter flavoring-exposed workers at a microwave popcorn plant, we sought to further characterize lung disease risk from airborne butter-flavoring chemicals. METHODS: We analyzed data from medical and environmental surveys at six microwave popcorn plants (including the index plant). RESULTS: Respiratory symptom and airways obstruction prevalences were higher in oil and flavorings mixers with longer work histories and in packaging-area workers near nonisolated tanks of oil and flavorings. Workers were affected at five plants, one with mixing-area exposure to diacetyl (a butter-flavoring chemical with known respiratory toxicity potential) as low as 0.02 ppm. CONCLUSIONS: Microwave popcorn workers at many plants are at risk for flavoring-related lung disease. Peak exposures may be hazardous even when ventilation maintains low average exposures. Respiratory protection and engineering controls are necessary to protect workers.
SN - 1076-2752
AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505; rkanwal@cdc.gov
U2 - PMID: 16474263.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106461582&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Valid Paired Data Designs: Make Full Use of the Data Without "Double-Dipping". (Editorial)
AU - Derr, Janice
JO - Journal of Orthopaedic & Sports Physical Therapy
JF - Journal of Orthopaedic & Sports Physical Therapy
Y1 - 2006/02//
VL - 36
IS - 2
SP - 42
EP - 44
CY - ;
SN - 01906011
N1 - Accession Number: SPHS-1017264; Author: Derr, Janice: 1 ; Author Affiliation: 1 Mathematical Statistician, US Food and Drug Administration, Silver Spring, MD, USA; No. of Pages: 3; Language: English; Parent Item: SPHP1980; References: 3; General Notes: Guest editorial.; Publication Type: Article; Material Type: PRINT; Update Code: 20060801; SIRC Article No.: S-1017264
N2 - The conceptual and statistical issues associated with paired data in musculoskeletal physical therapy research are discussed and a previous editorial on the subject is commented upon. The author recommends that while care must be taken there are three situations where an appropriate design and analysis for paired data may prove advantageous.
KW - *PHYSICAL therapy
KW - *MUSCULOSKELETAL system
KW - RESEARCH
KW - METHODOLOGY
KW - STATISTICS
L2 - http://articles.sirc.ca/search.cfm?id=S-1017264
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=SPHS-1017264&site=ehost-live&scope=site
UR - http://articles.sirc.ca/search.cfm?id=S-1017264
UR - http://www.apta.org/
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 106428798
T1 - Guest editorial. Valid paired data designs: make full use of the data without 'double-dipping'.
AU - Derr J
Y1 - 2006/02//2006 Feb
N1 - Accession Number: 106428798. Language: English. Entry Date: 20060421. Revision Date: 20150819. Publication Type: Journal Article; commentary; editorial; tables/charts. Original Study: Menz HB. Guest editorial. Analysis of paired data in physical therapy research: time to stop double-dipping? (J ORTHOP SPORTS PHYS THER) 2005 Aug; 35 (8): 477-478. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7908150.
KW - Research, Physical Therapy
KW - Data Analysis, Statistical -- Methods
SP - 42
EP - 44
JO - Journal of Orthopaedic & Sports Physical Therapy
JF - Journal of Orthopaedic & Sports Physical Therapy
JA - J ORTHOP SPORTS PHYS THER
VL - 36
IS - 2
CY - La Crosse, Wisconsin
PB - American Physical Therapy Association, Orthopaedic Section
SN - 0190-6011
AD - Mathematical Statistician, US Food and Drug Administration, Silver Spring, MD
U2 - PMID: 16494071.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106428798&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Amat, Albert
AU - Rigau, Josepa
AU - Waynant, Ronald W.
AU - Ilev, Ilko K.
AU - Anders, Juanita J.
T1 - The electric field induced by light can explain cellular responses to electromagnetic energy: A hypothesis of mechanism
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2006/02//
VL - 82
IS - 2
M3 - Article
SP - 152
EP - 160
SN - 10111344
AB - Abstract: When cells are irradiated with visible and near-infrared wavelengths a variety of stimulatory effects are observed in their metabolism. To explain the observed light effects, researchers try to identify the chromophores that are involved in the processes. However, the mechanism of light absorption by a chromophore does not explain many of the experimental observations and therefore the primary mechanism for cellular light responses remains unproven. In addition to the ability of photons to produce electronic excitation in chromophores, light induces a wave-like alternating electric field in a medium that is able to interact with polar structures and produce dipole transitions. These dipole transitions are analyzed in the present article at different cellular and biochemical levels, leading to the proposal that the primary mechanism for the observed light effects is related to the light-induced electric field. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology B: Biology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTOELECTROMAGNETIC effects
KW - ELECTRIC fields
KW - PHOTOELECTRICITY
KW - LUMINESCENCE
KW - ATP synthesis
KW - ATP/ADP ratio
KW - Ca2+ regulation
KW - Light-induced electric field mitochondria
KW - Na+/K+ ionic pump
KW - Photochemistry
KW - ROS
N1 - Accession Number: 19396097; Amat, Albert 1,2,3; Email Address: albert.amat@urv.net Rigau, Josepa 1 Waynant, Ronald W. 2 Ilev, Ilko K. 2 Anders, Juanita J. 3; Affiliation: 1: Histology and Neurobiology Unit, Faculty of Medicine and Health Sciences, Rovira i Virgili University, C. Sant Llorenç 21, 43201 Reus, Spain 2: Division of Physics, Centre for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, Rockville, MD 20857, United States 3: Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States; Source Info: Feb2006, Vol. 82 Issue 2, p152; Subject Term: PHOTOELECTROMAGNETIC effects; Subject Term: ELECTRIC fields; Subject Term: PHOTOELECTRICITY; Subject Term: LUMINESCENCE; Author-Supplied Keyword: ATP synthesis; Author-Supplied Keyword: ATP/ADP ratio; Author-Supplied Keyword: Ca2+ regulation; Author-Supplied Keyword: Light-induced electric field mitochondria; Author-Supplied Keyword: Na+/K+ ionic pump; Author-Supplied Keyword: Photochemistry; Author-Supplied Keyword: ROS; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jphotobiol.2005.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Konduru, Krishnamurthy
AU - Kaplan, Gerardo G.
T1 - Stable Growth of Wild-Type Hepatitis A Virus in Cell Culture.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/02//
VL - 80
IS - 3
M3 - Article
SP - 1352
EP - 1360
SN - 0022538X
AB - Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable of supporting the efficient growth of wt HAV, we transfected different cell lines with in vitro RNA transcripts of wt HAV containing the blasticidin resistance-gene. Blasticidin-resistant colonies grew only in transfected Huh7 cells and produced infectious virus. HAV was genetically stable in Huh7 cells for at least nine serial passages and did not accumulate attenuating or cell culture-adapting mutations. Treatment with alpha interferon A/D cured the blasticidin-resistant Huh7 cells of the HAV infection. The cured cells, termed Huh7-A-I cells, did not contain virus or HAV antigens and were sensitive to blasticidin. Huh7-A-I cells were more permissive than parental cells for wt HAV infection, including a natural isolate from a human stool sample, and produced 10-fold-more infectious particles. This is the first report of a cell line that allows the genetically stable growth of human wt HAV. The viral vectors and cells described here should allow better insight into the pathogenesis of HAV and the development of attenuated vaccines. The cell lines susceptible to wt HAV growth may also be used to detect and isolate infectious virus from patient and environmental samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - ENTEROVIRUSES
KW - HEPATITIS viruses
KW - GROWTH factors
KW - CELL culture
KW - VIRUS diseases
N1 - Accession Number: 20231750; Konduru, Krishnamurthy 1 Kaplan, Gerardo G. 1; Email Address: GK@Helix.NIH.gov; Affiliation: 1: Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Feb2006, Vol. 80 Issue 3, p1352; Subject Term: HEPATITIS A virus; Subject Term: ENTEROVIRUSES; Subject Term: HEPATITIS viruses; Subject Term: GROWTH factors; Subject Term: CELL culture; Subject Term: VIRUS diseases; Number of Pages: 9p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1128/JVI.80.3.1352-1360.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106450909
T1 - Accidental iatrogenic pneumothorax in hospitalized patients.
AU - Zhan C
AU - Smith M
AU - Stryer D
Y1 - 2006/02//
N1 - Accession Number: 106450909. Language: English. Entry Date: 20060602. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 0230027.
KW - Iatrogenic Disease -- Epidemiology
KW - Pneumothorax -- Epidemiology
KW - Treatment Errors -- Epidemiology
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Funding Source
KW - Inpatients
KW - Pneumothorax -- Etiology
KW - Risk Assessment
KW - Human
SP - 182
EP - 186
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Iatrogenic pneumothorax (IP) is an inherent risk to patients who undergo procedures that involve the intentional puncturing of the lung. IP also could occur accidentally to patients who do not undergo such procedures; such accidental IP (AIP) is suggestive of lapses in safe care. This study assessed the risk for AIP in patients hospitalized with specific diagnoses who underwent specific procedures. RESEARCH DESIGN: We analyzed 7.5 million discharge abstracts from 994 short-term acute care hospitals across 28 states in 2000 in the Agency for Healthcare Research and Quality (AHRQ), Healthcare Cost and Utilization Project Nationwide Inpatient Sample. AHRQ Patient Safety Indicators (PSIs) were used to identify AIP. AIP incidences and associated diagnoses and procedures were explored. RESULTS: Patients who were admitted for pleurisy, cancer of the kidney and renal pelvis, or conduction disorders and complications of cardiac devices had the highest rates of developing AIP during hospitalization, with AIP rates at 2.24%, 1.14%, and 0.83% respectively. The procedure-specific rates for AIP varied from 2.68% for patients who underwent thoracentesis to 1.30% for those who underwent nephrectomy, to 0.06% for those who underwent gastrostomy. Thoracentesis appeared to be a high-risk procedure for patients who were admitted for secondary malignancies, pleurisy, or pneumonia, with AIP rates at 3.76%, 3.13%, and 2.28%, respectively. CONCLUSIONS: Although AIP is most common after thoracentesis, it is a substantial threat to patients undergoing a wide range of procedures.
SN - 0025-7079
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; czhan@ahrq.gov
U2 - PMID: 16434918.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106450909&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Owens, Pamela L.
AU - Kerker, Bonnie D.
AU - Zigler, Edward
AU - Horwitz, Sarah M.
T1 - Vision and oral health needs of individuals with intellectual disabilityThis article is a US Government work and, as such, is in the public domain in the United States of America. .
JO - Mental Retardation & Developmental Disabilities Research Reviews
JF - Mental Retardation & Developmental Disabilities Research Reviews
Y1 - 2006/02//
VL - 12
IS - 1
M3 - Article
SP - 28
EP - 40
PB - John Wiley & Sons, Inc.
SN - 10804013
AB - Over the past 20 years, there has been an increased emphasis on health promotion, including prevention activities related to vision and oral health, for the general population, but not for individuals with intellectual disability (ID). This review explores what is known about the prevalence of vision problems and oral health conditions among individuals with ID, presents a rationale for the increased prevalence of these conditions in the context of service utilization, and examines the limitations of the available research. Available data reveal a wide range of prevalence estimates for vision problems and oral health conditions, but all suggest that these conditions are more prevalent among individuals with ID compared with the general population, and disparities exist in the receipt of preventive and early treatment for these conditions for individuals with ID. Recommendations for health improvement in these areas include better health planning and monitoring through standardized population-based data collection and reporting and increased emphasis on health promotion activities and early treatment in the healthcare system. MRDD Research Reviews 2006;12:28–40. © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEOPLE with mental disabilities
KW - VISION
KW - NUTRITION & dental health
KW - MENTAL disabilities
KW - HEALTH services accessibility
KW - MEDICAL care
KW - UNITED States
KW - dental
KW - intellectual disability
KW - vision
N1 - Accession Number: 19529818; Owens, Pamela L. 1; Email Address: powens@ahrq.gov Kerker, Bonnie D. 2 Zigler, Edward 3,4 Horwitz, Sarah M. 4,5; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: New York City Department of Health and Mental Hygiene, New York, New York 3: Department of Psychology, Yale University, New Haven, Connecticut 4: Child Study Center, Yale University School of Medicine, New Haven, Connecticut 5: Department of Epidemiology and Biostatistics, Pediatrics and Psychiatry, Case Western Reserve University, Cleveland, Ohio; Source Info: 2006, Vol. 12 Issue 1, p28; Subject Term: PEOPLE with mental disabilities; Subject Term: VISION; Subject Term: NUTRITION & dental health; Subject Term: MENTAL disabilities; Subject Term: HEALTH services accessibility; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: dental; Author-Supplied Keyword: intellectual disability; Author-Supplied Keyword: vision; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1002/mrdd.20096
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goyal, Neena
AU - Duncan, Robert
AU - Selvapandiyan, Angamuthu
AU - Debrabant, Alain
AU - Baig, Mirza S.
AU - Nakhasi, Hira L.
T1 - Cloning and characterization of angiotensin converting enzyme related dipeptidylcarboxypeptidase from Leishmania donovani
JO - Molecular & Biochemical Parasitology
JF - Molecular & Biochemical Parasitology
Y1 - 2006/02//
VL - 145
IS - 2
M3 - Article
SP - 147
EP - 157
SN - 01666851
AB - Abstract: We report the first identification, gene cloning, recombinant expression and biochemical characterization of an angiotensin converting enzyme (ACE) related dipeptidylcarboxypeptidase (DCP) in a protozoan parasite. The mammalian counterpart of this enzyme, peptidyl dipeptidase A (a carboxyl dipeptidase) also known as ACE leads to the cleavage of angiotensin I to produce a potent vasopressor. The catalytic enzyme activity of its Escherichia coli DCP counter part can be inhibited by the antihypertensive drug captopril, suggesting that this class of enzymes constitutes a novel target for drugs and vaccines. By utilizing a DNA microarray expression profiling approach, we identified a gene encoding a DCP enzyme for the kinetoplast protozoan Leishmania donovani (LdDCP) that was differentially expressed in promastigote and amastigote stages of the parasite life cycle. Both RNA and protein levels of LdDCP are higher in axenic amastigotes compared to promastigotes. Immuno-fluorescence analysis revealed the cytosolic expression of the protein. Primary structure analysis of LdDCP revealed the presence of an active Zn binding site. When expressed in E. coli, the recombinant enzyme showed carboxy-dipeptidase activity with synthetic substrates. Replacement of two histidine and one glutamic acid at positions 466, 470 and 467, respectively, with alanine residues in its active site resulted in loss of enzyme activity. Captopril, an ACE specific inhibitor was able both to reduce significantly LdDCP enzyme activity and to inhibit promastigote growth. Both its cytosolic location and close homology to DCPs from bacterial species suggests a role in parasite nutrition. Further, identification of LdDCP now provides an opportunity to investigate Leishmania peptidases for their potential as drug and vaccine targets. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Biochemical Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Molecular cloning
KW - Angiotensins
KW - Enzymes
KW - Vasoconstrictors
KW - Dipeptidylcarboxypeptidase
KW - Drug target
KW - Exopeptidases
KW - Kala-azar
KW - Leishmania donovani
N1 - Accession Number: 19464585; Goyal, Neena 1; Email Address: neenacdri@yahoo.com; Duncan, Robert 2; Selvapandiyan, Angamuthu 2; Debrabant, Alain 2; Baig, Mirza S. 1; Nakhasi, Hira L. 2; Affiliations: 1: Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India; 2: Division of Emerging and Transfusion Transmitted Diseases, Centre for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Feb2006, Vol. 145 Issue 2, p147; Subject Term: Molecular cloning; Subject Term: Angiotensins; Subject Term: Enzymes; Subject Term: Vasoconstrictors; Author-Supplied Keyword: Dipeptidylcarboxypeptidase; Author-Supplied Keyword: Drug target; Author-Supplied Keyword: Exopeptidases; Author-Supplied Keyword: Kala-azar; Author-Supplied Keyword: Leishmania donovani; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.molbiopara.2005.09.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xiaoming Hu
AU - Roberts, Jenny R.
AU - Apopa, Patrick L.
AU - Yuet Wai Kan
AU - Qiang Ma
T1 - Accelerated Ovarian Failure Induced by 4-Vinyl Cyclohexene Diepoxide in Nrf2 Null Mice.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2006/02//
VL - 26
IS - 3
M3 - Article
SP - 18
EP - 18
SN - 02707306
AB - Genetic and biochemical analyses have uncovered an essential role for nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating phase II xenobiotic metabolism and antioxidant response. Here we show that Nrf2 protects against the ovarian toxicity of 4-vinylcyclohexene diepoxide (VCD) in mice. Nrf2-/- female mice exposed to VCD exhibit an age-dependent decline in reproduction leading to secondary infertility accompanied by hypergonadotropic hypogonadism after 30 weeks of age. VCD is shown to selectively destroy small ovarian follicles, resulting in early depletion of functional follicles. Treatment with VCD induces apoptotic death in cultured cells and in ovarian follicles, suggesting apoptosis as a mechanism of follicle loss. Loss of Nrf2 function blocks the basal and inducible expression of microsomal epoxide hydrolase, a key enzyme in the detoxification of VCD, and increases the oxidative stress in cells that is further exacerbated by VCD. Foxo3a, a repressor in the early stages of follicle activation, displays reduced expression in Nrf2-/- ovaries, causing accelerated growth of follicles in the absence of exposure to exogenous chemicals. Furthermore, Foxo3a is degraded through the 26S proteasome pathway in untreated cells and is induced by VCD via both Nrf2-dependent transcription and protein stabilization. This study demonstrates that Nrf2 serves as an essential sensor and regulator of chemical homeostasis in ovarian cells, protecting the cells from toxic chemicals by controlling metabolic detoxification, reactive oxygen species defense, and Foxo3a expression. In addition, these findings raise the possibility that exposure to environmental or occupational ovotoxicants plays a role in the premature ovarian failure commonly associated with infertility and premature aging in women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL genetics
KW - BIOCHEMISTRY
KW - CELLS
KW - TRANSCRIPTION factors
KW - EPOXY compounds
KW - MICE
KW - HYPOGONADISM
KW - OVARIAN diseases
N1 - Accession Number: 20581006; Xiaoming Hu 1,2 Roberts, Jenny R. 3 Apopa, Patrick L. 1,4 Yuet Wai Kan 5 Qiang Ma 1; Email Address: qam1@cdc.gov; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, West Virginia University, Morgantown, West Virginia 2: Abbott Laboratories, Abbott Park, IL 60064-6122 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, West Virginia University, Morgantown, West Virginia 4: Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, West Virginia 5: Department of Laboratory Medicine and Howard Hughes Medical Institute, University of California, San Francisco, California; Source Info: Feb2006, Vol. 26 Issue 3, p18; Subject Term: BIOCHEMICAL genetics; Subject Term: BIOCHEMISTRY; Subject Term: CELLS; Subject Term: TRANSCRIPTION factors; Subject Term: EPOXY compounds; Subject Term: MICE; Subject Term: HYPOGONADISM; Subject Term: OVARIAN diseases; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/MCB.26.3.940-954.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yoshitomi, Ken J.
AU - Jinneman, Karen C.
AU - Weagant, Stephen D.
T1 - Detection of Shiga toxin genes stx1, stx2, and the +93 uidA mutation of E. coli O157:H7/H-using SYBR® Green I in a real-time multiplex PCR
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2006/02//
VL - 20
IS - 1
M3 - Article
SP - 31
EP - 41
SN - 08908508
AB - Abstract: Enterohemorrhagic Escherichia coli (EHEC) is a major foodborne pathogen capable of causing diarrhea and vomiting, but more serious complications such as hemorrhagic colitis and hemolytic-uremic syndrome (HUS) can result. A real-time PCR method to detect the presence of Shiga toxin producing E. coli (STEC) and E. coli O157:H7 was investigated using SYBR® Green I (SG). Primers were designed to target the Shiga toxin genes (stx1 and stx2) and a highly conserved base substitution at +93 of the β-glucuronidase gene (uidA) unique to E. coli O157:H7. An initial test panel of five E. coli and non-E. coli isolates was tested with individual primer sets (simplex assay) and all primer sets including stx1, stx2, and uidA(multiplex assay). All strains were correctly identified in both assays. Average melt temperatures (T m''s, °C) for PCR products were 85.42-stx1, 81.93-stx2, and 88.25-uidA in simplex assays and 85.20-stx1, 81.20-stx2, and 88.16-uidA when multiplexed. Each of the three gene targets in one multiplex reaction could be distinguished by melt curve data with significantly different T m''s. The assay was expanded to a panel of 138 isolates consisting of STEC, E. coli O157:H7, non-toxigenic E. coli, and non-E. coli isolates with melt peaks consistent with those stated above. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - MUTATION (Biology)
KW - ESCHERICHIA coli O157:H7
KW - ENTEROBACTERIACEAE
KW - E. coli O157:H7
KW - Real-time PCR
KW - STEC
KW - SYBR Green I
N1 - Accession Number: 19766269; Yoshitomi, Ken J. 1,2; Email Address: ken.yoshitomi@fda.gov Jinneman, Karen C. 1,2 Weagant, Stephen D. 2; Affiliation: 1: Seafood Products Research Center, US Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021-4421, USA 2: Pacific Regional Laboratory Northwest, U.S. Food and Drug Administration, 22201 23rd Drive SE, Bothell, WA 98021-4421, USA; Source Info: Feb2006, Vol. 20 Issue 1, p31; Subject Term: ESCHERICHIA coli; Subject Term: MUTATION (Biology); Subject Term: ESCHERICHIA coli O157:H7; Subject Term: ENTEROBACTERIACEAE; Author-Supplied Keyword: E. coli O157:H7; Author-Supplied Keyword: Real-time PCR; Author-Supplied Keyword: STEC; Author-Supplied Keyword: SYBR Green I; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mcp.2005.09.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19766269&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biernath, Krista R.
AU - Reefhuis, Jennita
AU - Whitney, Cynthia G.
AU - Mann, Eric A.
AU - Costa, Pamela
AU - Eichwald, John
AU - Boyle, Coleen
T1 - Bacterial Meningitis Among Children With Cochlear Implants Beyond 24 Months After Implantation.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/02//
VL - 117
IS - 2
M3 - Article
SP - 284
EP - 289
SN - 00314005
AB - BACKGROUND. More than 11 000 children in the United States with severe-to-profound hearing loss have cochlear implants. A 2002 investigation involving pediatric cochlear implant recipients identified meningitis episodes from January 1, 1997, through September 15, 2002. The incidence of pneumococcal meningitis in the cohort was 138.2 cases per 100 000 person-years, >30 times higher than that for children in the general US population. Children with implants with positioners were at higher risk than children with other implant models. This higher risk of bacterial meningitis continued for up to 24 months after implantation. OBJECTIVE. To evaluate additional reported cases to determine whether the increased rate of bacterial meningitis among children with cochlear implants extended beyond 24 months after implantation. METHODS. Our study population consisted of the cohort of children identified through the 2002 investigation; it included 4265 children who received cochlear implants in the United States between January 1, 1997, and August 6, 2002, and who were <6 years of age at the time of implantation. We calculated updated incidence rates and incidence according to time since implantation. RESULTS. We identified 12 new episodes of meningitis for 12 children. Eleven of the children had implants with positioners; 2 children died. Six episodes occurred >24 months after implantation. When cases identified in the 2002 and 2004 investigations were combined, the incidence rate of ≥24-months postimplantation bacterial meningitis among children with positioners was 450 cases per 100 000 person-years, compared with no cases among children without positioners. CONCLUSIONS. Our updated findings support continued monitoring and prompt treatment of bacterial infections by health care providers and parents of children with cochlear implants. This vigilance remains important beyond 2 years after implantation, particularly among children with positioners. The vaccination recommendations for all children with implants, with and without positioners, and all potential recipients of implants continue to apply. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- United States
KW - DEAFNESS
KW - COCHLEAR implants
KW - DEAF children
KW - MENINGITIS
KW - UNITED States
KW - bacterial infections
KW - hearing loss
KW - intervention
KW - meningitis
N1 - Accession Number: 19857013; Biernath, Krista R. 1; Email Address: kbiernath@cdc.gov Reefhuis, Jennita 1 Whitney, Cynthia G. 2 Mann, Eric A. 3 Costa, Pamela 1 Eichwald, John 1 Boyle, Coleen 1; Affiliation: 1: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 2: National Center for Infectious Diseases, Centers fur Disease Control and Prevention, Atlanta, Georgia 3: Food and Drug Administration Rockville, Maryland; Source Info: Feb2006, Vol. 117 Issue 2, p284; Subject Term: CHILDREN -- United States; Subject Term: DEAFNESS; Subject Term: COCHLEAR implants; Subject Term: DEAF children; Subject Term: MENINGITIS; Subject Term: UNITED States; Author-Supplied Keyword: bacterial infections; Author-Supplied Keyword: hearing loss; Author-Supplied Keyword: intervention; Author-Supplied Keyword: meningitis; Number of Pages: 6p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2005-0824
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chourey, Prem S.
AU - Jain, Mukesh
AU - Qin-Bao Li
AU - Carlson, Susan J.
T1 - Genetic control of cell wall invertases in developing endosperm of maize.
JO - Planta
JF - Planta
Y1 - 2006/02//
VL - 223
IS - 2
M3 - Article
SP - 159
EP - 167
PB - Springer Science & Business Media B.V.
SN - 00320935
AB - We show here that the total invertase activity in developing seeds of maize is due to two cell wall invertase (CWI) genes, Incw1 and Incw2 ( Mn1). Our previous results have shown that loss-of-function mutations at the Mn1 locus lead to the miniature-1 ( mn1) seed phenotype, marked by a loss of >70% of seed weight at maturity. The mn1 seed mutant is, however, non-lethal presumably because it retains a residual low level, ∼1%, of the total CWI activity relative to the Mn1 endosperm throughout seed development. Evidence here shows that the residual activity in the mn1 mutant is encoded by the Incw1 gene. RNA level analyses, especially quantitative real-time PCR studies, showed significant spatial and temporal heterogeneity in the expression of the two CWI genes in the developing endosperm. The Mn1-encoded Incw2 transcripts were seen at the highest levels in the basal region (the sugar unloading zone) during the early phase of cell division and elongation in the endosperm. In contrast, the highest levels of Incw1 transcripts were seen in the storage phase in both the upper (storage cells) and the lower parts of the endosperm. Protein and enzyme level analyses, however, appeared to show a lack of concordance with the RNA level of expression in both the Mn1 and mn1 endosperms, indicating a possibility of post-transcriptional control in the expression of these two genes. Collectively, the data suggest an important role for apoplastic cleavage of sucrose throughout the duration of seed development; and, of the two isoforms, the INCW2 appears to control metabolic flux of sugar utilization in the developing endosperm. [ABSTRACT FROM AUTHOR]
AB - Copyright of Planta is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Corn
KW - Mutation (Biology)
KW - Seeds
KW - Plant genetics
KW - Plant cell walls
KW - Sugar
KW - Phenotype
KW - Genetic transcription
KW - Genetic code
KW - Cell wall invertase
KW - Developing seed
KW - Sink strength
KW - Zea mays L
N1 - Accession Number: 19246184; Chourey, Prem S. 1; Email Address: pschourey@ifas.ufl.edu; Jain, Mukesh 2; Qin-Bao Li 1; Carlson, Susan J. 3; Affiliations: 1: U. S. Department of Agriculture, Agricultural Research Service, CMAVE, Gainesville, FL 32611-0680 USA; 2: Program in Plant Molecular & Cellular Biology, Departments of Plant Pathology and Agronomy, University of Florida, Gainesville, Florida 32611-0680 USA; 3: Food and Drug Administration, Rockville, MD, USA; Issue Info: Feb2006, Vol. 223 Issue 2, p159; Thesaurus Term: Corn; Thesaurus Term: Mutation (Biology); Thesaurus Term: Seeds; Subject Term: Plant genetics; Subject Term: Plant cell walls; Subject Term: Sugar; Subject Term: Phenotype; Subject Term: Genetic transcription; Subject Term: Genetic code; Author-Supplied Keyword: Cell wall invertase; Author-Supplied Keyword: Developing seed; Author-Supplied Keyword: Sink strength; Author-Supplied Keyword: Zea mays L; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 418320 Seed merchant wholesalers; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 311314 Cane Sugar Manufacturing; NAICS/Industry Codes: 311310 Sugar manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s00425-005-0039-5
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murono, Eisuke P.
AU - Derk, Raymond C.
AU - Akgul, Yucel
T1 - In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2006/02//
VL - 21
IS - 2
M3 - Article
SP - 148
EP - 153
SN - 08906238
AB - Abstract: Methoxychlor (MC) was developed as a replacement for the banned pesticide DDT. After in vivo administration, it is metabolized in the liver to 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which is proposed to be the active agent. Both MC and HPTE have been shown to exhibit weak estrogenic and antiandrogenic activities, and they are thought to exert their effects through estrogen and androgen receptors, respectively. Although in vitro studies using cultured rat Leydig cells have reported that HPTE inhibits both basal and hCG-stimulated testosterone formation, the response of circulating testosterone levels to in vivo MC has been more variable. Therefore, the current studies evaluated whether the daily in vivo administration of MC (0, 5, 40 and 200mg/kg body weight) for a short duration (days 54–60 of age) by gavage altered serum testosterone levels and ex vivo Leydig cell testosterone formation in young adult male rats. These results demonstrate that both fluid-retained and fluid-expressed seminal vesicle weights declined to 44 and 60% of control, respectively, in the 200mg/kg MC-exposed animals. Similarly, serum testosterone and dehydroepiandrosterone levels declined to 41 and 45% of control, respectively, in the 200mg/kg MC-exposed animals; however, serum LH and FSH levels were unaffected. Ex vivo Leydig cell basal testosterone formation over 4h declined to 49% of control in animals exposed to 200mg/kg MC, and ex vivo Leydig cell P450 cholesterol side-chain cleavage activity declined to 79 and 50% of control in animals exposed to 40 and 200mg/kg of MC, respectively, supporting previous in vitro studies which demonstrated the sensitivity of this step to MC. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TESTOSTERONE
KW - ORGANOCHLORINE compounds
KW - BLOOD plasma
KW - ISOPENTENOIDS
KW - Adult male rats
KW - Methoxychlor
KW - Testosterone
N1 - Accession Number: 19395177; Murono, Eisuke P. 1,2; Email Address: eem8@cdc.gov Derk, Raymond C. 1 Akgul, Yucel 2; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA 2: Department of Physiology and Pharmacology, West Virginia University (Y.A.), Morgantown, USA; Source Info: Feb2006, Vol. 21 Issue 2, p148; Subject Term: TESTOSTERONE; Subject Term: ORGANOCHLORINE compounds; Subject Term: BLOOD plasma; Subject Term: ISOPENTENOIDS; Author-Supplied Keyword: Adult male rats; Author-Supplied Keyword: Methoxychlor; Author-Supplied Keyword: Testosterone; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.reprotox.2005.08.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schachter, E. Neil
AU - Zuskin, Eugenija
AU - Buck, Marion
AU - Witek, Theodore J.
AU - Godbold, James
AU - Roy, Noah
AU - Castranova, Vincent
AU - Whitmer, Michael
AU - Siegel, Paul D.
AU - Bluhm, Elisabeth C.
T1 - Airway Responses to the Inhalation of Cotton Dust and Cotton Bract Extracts.
JO - Respiration
JF - Respiration
Y1 - 2006/02//
VL - 73
IS - 1
M3 - Article
SP - 41
EP - 47
SN - 00257931
AB - Background: Exposure to dust in the cotton industry is associated with respiratory dysfunction. Healthy subjects challenged with cotton bract extract (CBE) develop transient airway hyperresponsiveness. CBE, a major component of cotton dust, is potentially an important agent for studying byssinosis. Objectives: To compare airway responses to cotton dust extract (CDE) and CBE in healthy subjects. Methods: In 21 healthy, non-smoking subjects we compared the effects of CBE and CDE in a double-blind random order, following a 10-min aerosol inhalation. The response to methacholine (MCh) 2 h following CBE or CDE was measured. Lung function was recorded using maximal (MEFV) and partial expiratory flow volume (PEFV) curves, measuring MEF at 60% of baseline vital capacity below total lung capacity [MEF40%(P)] on the PEFV curve. Responders were subjects who developed a 20% or greater fall in MEF40%(P) following extract challenge. Endotoxin levels were low for CBE (5.71 EU/mg) and CDE (31.88 EU/mg). Results: There were 18 responders to CBE and 17 responders to CDE.The average maximal falls in MEF40%(P) were 70 ± 4.9 and 70 ± 4.4% of baseline (nonsignificant) following CBE and CDE, respectively. All subjects enhanced their MCh response following CBE or CDE. The MCh dose which reduced MEF40%(P) by 40% was identical for CBE and CDE (1.3 μg/ml). Conclusions: We conclude that CBE and CDE exert similar physiologic effects. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Respiration is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BYSSINOSIS
KW - LUNGS -- Dust diseases
KW - TEXTILE workers -- Diseases
KW - COTTON
KW - CARDIOPULMONARY system
KW - Airway hyperresponsiveness
KW - Byssinosis
KW - Cotton bract
KW - Cotton dust
N1 - Accession Number: 19886355; Schachter, E. Neil 1; Email Address: neil.schachter@mssm.edu Zuskin, Eugenija 2 Buck, Marion 1 Witek, Theodore J. 1 Godbold, James 3 Roy, Noah 3 Castranova, Vincent 4 Whitmer, Michael 4 Siegel, Paul D. 4 Bluhm, Elisabeth C. 1; Affiliation: 1: Department of Pulmonary Medicine, New York, N.Y., USA 2: Andrija Stampar School of Public Health, Zagreb, Croatia 3: Mount Sinai School of Medicine, New York, N.Y., USA 4: National Institute of Occupational Safety and Health, Morgantown, W.Va, USA; Source Info: 2006, Vol. 73 Issue 1, p41; Subject Term: BYSSINOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: TEXTILE workers -- Diseases; Subject Term: COTTON; Subject Term: CARDIOPULMONARY system; Author-Supplied Keyword: Airway hyperresponsiveness; Author-Supplied Keyword: Byssinosis; Author-Supplied Keyword: Cotton bract; Author-Supplied Keyword: Cotton dust; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 111920 Cotton Farming; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 313310 Textile and Fabric Finishing Mills; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 314990 All other textile product mills; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1159/000088354
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19886355&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Robert M.
AU - Stayner, Leslie T.
T1 - A Search for Thresholds and Other Nonlinearities in the Relationship Between Hexavalent Chromium and Lung Cancer.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2006/02//
VL - 26
IS - 1
M3 - Article
SP - 79
EP - 88
PB - Wiley-Blackwell
SN - 02724332
AB - The exposure-response relationship for airborne hexavalent chromium exposure and lung cancer mortality is well described by a linear relative rate model. However, categorical analyses have been interpreted to suggest the presence of a threshold. This study investigates nonlinear features of the exposure response in a cohort of 2,357 chemical workers with 122 lung cancer deaths. In Poisson regression, a simple model representing a two-step carcinogenesis process was evaluated. In a one-stage context, fractional polynomials were investigated. Cumulative exposure dose metrics were examined corresponding to cumulative exposure thresholds, exposure intensity (concentration) thresholds, dose-rate effects, and declining burden of accumulated effect on future risk. A simple two-stage model of carcinogenesis provided no improvement in fit. The best-fitting one-stage models used simple cumulative exposure with no threshold for exposure intensity and had sufficient power to rule out thresholds as large as 30 μg/m3 CrO3 (16 μg/m3 as Cr+6) (one-sided 95% confidence limit, likelihood ratio test). Slightly better-fitting models were observed with cumulative exposure thresholds of 0.03 and 0.5 mg-yr/m3 (as CrO3) with and without an exposure-race interaction term, respectively. With the best model, cumulative exposure thresholds as large as 0.4 mg-yr/m3 CrO3 were excluded (two-sided upper 95% confidence limit, likelihood ratio test). A small departure from dose-rate linearity was observed, corresponding to (intensity)0.8 but was not statistically significant. Models in which risk-inducing damage burdens declined over time, based on half-lives ranging from 0.1 to 40 years, fit less well than assuming a constant burden. A half-life of 8 years or less was excluded (one-sided 95% confidence limit). Examination of nonlinear features of the hexavalent chromium-lung cancer exposure response in a population used in a recent risk assessment supports using the traditional (lagged) cumulative exposure paradigm: no intensity (concentration) threshold, linearity in intensity, and constant increment in risk following exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hexavalent chromium
KW - Risk assessment
KW - Carcinogenesis
KW - Lungs -- Cancer
KW - Poisson processes
KW - Regression analysis
KW - Burden
KW - dose rate
KW - nonlinear exposure response
KW - threshold
KW - two-stage
N1 - Accession Number: 19792396; Park, Robert M. 1; Email Address: rhp9@cdc.go; Stayner, Leslie T. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, OH, USA; 2: School of Public Health, University of Illinois, Chicago, Chicago, IL, USA; Issue Info: Feb2006, Vol. 26 Issue 1, p79; Thesaurus Term: Hexavalent chromium; Thesaurus Term: Risk assessment; Thesaurus Term: Carcinogenesis; Subject Term: Lungs -- Cancer; Subject Term: Poisson processes; Subject Term: Regression analysis; Author-Supplied Keyword: Burden; Author-Supplied Keyword: dose rate; Author-Supplied Keyword: nonlinear exposure response; Author-Supplied Keyword: threshold; Author-Supplied Keyword: two-stage; Number of Pages: 10p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1539-6924.2006.00709.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Claycamp, H. Gregg
T1 - Rapid Benefit-Risk Assessments: No Escape from Expert Judgments in Risk Management.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2006/02//
VL - 26
IS - 1
M3 - Article
SP - 147
EP - 156
PB - Wiley-Blackwell
SN - 02724332
AB - The “human health impacts assessment” described by Cox and Popken (this issue) is intended to be a benefit-risk tool that avoids pitfalls of using expert judgments for policy analysis or during strict application of the precautionary principle in risk management. The proposed benefit-risk calculation uses numerous assumptions and suppositions to calculate a ratio of quality-adjusted life years (QALYs) lost for the number of human illness days prevented by the use of a food-animal antimicrobial drug, to the number of human illness days caused by the use of the antimicrobial drug. Assumptions about data—e.g., expert judgments on the representativeness of parameter estimates—are commonly used in risk assessment and risk management, including Cox and Popken's method. Cox and Popken apply the technique to specific examples of enrofloxacin and macrolides antimicrobial drugs, sometimes used in broiler chickens for human food. Although enthusiastically portrayed as a straightforward calculation of QALYs lost for two decision alternatives, Cox and Popken were silent on the pivotal expert judgment subsumed in their method: quality weights for illnesses caused by antimicrobial-resistant and antimicrobial-sensitive microbes are tacitly assumed to be equal. Yet, the costs in terms of prolonged illness, additional medications, repeat medical visits, and dread of more serious sequelae are expected to differ substantially for antimicrobial-resistant versus antimicrobial-sensitive illnesses. Despite their enthusiasm to the contrary, the “human health impacts assessment” by Cox and Popken is not immune from expert judgments in risk management. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Anti-infective agents
KW - Antibiotics
KW - Drugs
KW - Risk management in business
KW - Macrolide antibiotics
KW - Benefits assessment
KW - expert judgment
KW - microbial risk assessment
KW - policy making
KW - probalistic risk assessment
KW - quality-adjusted life years
N1 - Accession Number: 19792381; Claycamp, H. Gregg 1; Email Address: hclaycam@cvm.fda.gov; Affiliations: 1: Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Pl., HFV-102, Rockville, MD 20855, USA; Issue Info: Feb2006, Vol. 26 Issue 1, p147; Thesaurus Term: Risk assessment; Thesaurus Term: Anti-infective agents; Thesaurus Term: Antibiotics; Thesaurus Term: Drugs; Subject Term: Risk management in business; Subject Term: Macrolide antibiotics; Author-Supplied Keyword: Benefits assessment; Author-Supplied Keyword: expert judgment; Author-Supplied Keyword: microbial risk assessment; Author-Supplied Keyword: policy making; Author-Supplied Keyword: probalistic risk assessment; Author-Supplied Keyword: quality-adjusted life years; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1111/j.1539-6924.2006.00724.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19792381&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Isenbarger, Daniel W.
AU - Atwood, J. Edwin
AU - Scott, Paul T.
AU - Bateson, Thomas
AU - Coyle, Louis C.
AU - Gillespie, David L.
AU - Pearse, Lisa A.
AU - Villines, Todd C.
AU - Cassimatis, Dimitri C.
AU - Finelli, Louis N.
AU - Taylor, Allen J.
AU - Grabenstein, John D.
T1 - Venous thromboembolism among United States soldiers deployed to Southwest Asia
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2006/02//
VL - 117
IS - 4
M3 - Article
SP - 379
EP - 383
SN - 00493848
AB - Abstract: Introduction: Military operations may represent a high-risk environment for venous thromboembolism (VTE). We sought to identify and describe cases of venous thromboembolism among US military personnel serving in Southwest Asia, and estimate relative disease rates compared to non-deployed personnel. Materials and methods: Retrospective review of imaging archives, hospital discharge codes, case logs and autopsy records for the diagnosis of deep vein thrombosis or pulmonary embolism occurring from 1 March 2003 through 29 February 2004 among U.S. military personnel deployed to Southwest Asia. Rates of disease in deployed and non-deployed active-duty soldiers were estimated using personnel data and deployment experience obtained from automated rosters. Results: Forty cases of venous thromboembolism were identified. The case-fatality rate was 16% (3/19) among those with pulmonary embolism. Antecedent trauma followed by prolonged air evacuation was present in 55% (22/40). Compared to trauma-associated cases, non-trauma cases were more commonly over 40 years old (44% vs. 5%; p <0.05), assigned to a transportation or quartermaster company (56% vs. 14%; p <0.05), or had a history of remote venous thromboembolism (31% vs. 0%; p <0.05). The overall incidence among deployed active-duty soldiers was 22.1/100,000 person-years. Compared to non-deployed active-duty soldiers, the age-adjusted incidence rate ratio was 1.06 (CI0.95 0.68–1.67). Conclusions: VTE rates among deployed soldiers are relatively low compared to the general population, and are comparable to non-deployed soldiers. Fatalities from PE are not uncommon, and vigilance among clinicians remains warranted. Trauma followed by prolonged air evacuation or ground transport during military operations may represent unique interactive risk factors for venous thromboembolism. [Copyright &y& Elsevier]
AB - Copyright of Thrombosis Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THROMBOPHLEBITIS
KW - MILITARY personnel -- Diseases
KW - THROMBOSIS -- Diagnosis
KW - PULMONARY embolism
KW - DIAGNOSIS
KW - UNITED States
KW - deep vein thrombosis ( DVT )
KW - International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM )
KW - Military
KW - pulmonary embolism ( PE )
KW - Southwest Asia
KW - Thromboembolism
KW - Venous
KW - venous thromboembolism ( VTE )
N1 - Accession Number: 19607026; Isenbarger, Daniel W. 1,2; Email Address: isenbargerdw@hotmail.com Atwood, J. Edwin 1 Scott, Paul T. 3 Bateson, Thomas 3 Coyle, Louis C. 4 Gillespie, David L. 5 Pearse, Lisa A. 6 Villines, Todd C. 1 Cassimatis, Dimitri C. 1 Finelli, Louis N. 6 Taylor, Allen J. 1 Grabenstein, John D. 7; Affiliation: 1: Cardiology Service, Walter Reed Army Medical Center, Washington, DC, United States 2: Cardiology Division, Johns Hopkins Hospital, 600 N. Wolfe St, Carnegie 568 Cardiology, Baltimore, MD 21287, United States 3: Army Medical Surveillance Activity, US Army Center for Health Promotion and Preventive Medicine, Washington, DC, United States 4: Cardiology Service, Landstuhl Regional Medical Center, Landstuhl, Germany 5: Vascular Surgery Service, Walter Reed Army Medical Center, United States 6: Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Rockville, MD, United States 7: United States Army Office of the Surgeon General, Falls Church, VA, United States; Source Info: Feb2006, Vol. 117 Issue 4, p379; Subject Term: THROMBOPHLEBITIS; Subject Term: MILITARY personnel -- Diseases; Subject Term: THROMBOSIS -- Diagnosis; Subject Term: PULMONARY embolism; Subject Term: DIAGNOSIS; Subject Term: UNITED States; Author-Supplied Keyword: deep vein thrombosis ( DVT ); Author-Supplied Keyword: International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM ); Author-Supplied Keyword: Military; Author-Supplied Keyword: pulmonary embolism ( PE ); Author-Supplied Keyword: Southwest Asia; Author-Supplied Keyword: Thromboembolism; Author-Supplied Keyword: Venous; Author-Supplied Keyword: venous thromboembolism ( VTE ); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.thromres.2005.04.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stefaniak, Aleksandr B.
AU - Day, Gregory A.
AU - Hoover, Mark D.
AU - Breysse, Patrick N.
AU - Scripsick, Ronald C.
T1 - Differences in dissolution behavior in a phagolysosomal simulant fluid for single-constituent and multi-constituent materials associated with beryllium sensitization and chronic beryllium disease
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2006/02//
VL - 20
IS - 1
M3 - Article
SP - 82
EP - 95
SN - 08872333
AB - Abstract: Particle dissolution within macrophage phagolysosomes is hypothesized to be an important source of dissolved beryllium for input to the cell-mediated immune reaction associated with development of beryllium sensitization and chronic beryllium disease (CBD). To better understand the dissolution of beryllium materials associated with elevated prevalence of sensitization and CBD, single-constituent (beryllium oxide (BeO) particles sampled from a screener operation, finished product BeO powder, finish product beryllium metal powder) and multi-constituent (particles sampled from an arc furnace during processing of copper–beryllium alloy) aerosol materials were studied. Dissolution rates were measured using phagolysosomal simulant fluid (PSF) in a static dissolution technique and then normalized to measured values of specific surface area to calculate a chemical dissolution rate constant (k) for each material. Values of k, in g/(cm2 day), for screener BeO particles (1.3±1.9×10−8) and for BeO powder (1.1±0.5×10−8) were similar (p =0.45). The value of k observed for beryllium metal powder (1.1±1.4×10−7) was significantly greater than observed for the BeO materials (p <0.0003). For arc furnace particles, k (1.6±0.6×10−7) was significantly greater than observed for the BeO materials (p <0.00001), despite the fact that the chemical form of beryllium in the aerosol was BeO. These results suggest that dissolution of beryllium differs among physicochemical forms of beryllium and direct measurement of dissolution is needed for multi-constituent aerosol. Additional studies of the dissolution behavior of beryllium materials in a variety of mixture configurations will aid in developing exposure–response models to improve understanding of the risk of beryllium sensitization and CBD. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Particles
KW - Beryllium
KW - Cellular immunity
KW - Macrophages
KW - Chronic diseases
KW - σ g, geometric standard deviation
KW - σ, ln(σ g)
KW - , mass fraction remaining from a log-normally distributed population of homogeneous particles
KW - ABDC, alkylbenzyldimethylammonium chloride
KW - ANOVA, one-way analysis of variance
KW - BeO, beryllium oxide
KW - CBD, chronic beryllium disease
KW - CMD, count median diameter
KW - Cu2O, copper(I) oxide
KW - CuO, copper(II) oxide
KW - D m, mass median diameter
KW - Dissolution
KW - HCl, hydrochloric acid
KW - ICP-MS, inductively coupled plasma-mass spectroscopy
KW - k, chemical dissolution rate constant
KW - M 0, initial particulate beryllium mass
KW - M D, dissolved beryllium mass
KW - Multi-constituent aerosol
KW - Phagolysosome
KW - PSF, phagolysosomal simulant fluid
KW - SSA, specific surface area
KW - SSAeff, effective SSA
KW - SUF, serum ultrafiltrate
KW - US EPA, United States Environmental Protection Agency
KW - XPS, X-ray photoelectron spectroscopy
N1 - Accession Number: 19200107; Stefaniak, Aleksandr B. 1,2; Email Address: astefaniak@cdc.gov; Day, Gregory A. 3; Hoover, Mark D. 3; Breysse, Patrick N. 2; Scripsick, Ronald C. 1; Affiliations: 1: Industrial Hygiene and Safety Group, MS K553, Los Alamos National Laboratory, Los Alamos, NM 87545, United States; 2: Division of Environmental Health Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, United States; 3: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2800, Morgantown, WV 26505, United States; Issue Info: Feb2006, Vol. 20 Issue 1, p82; Thesaurus Term: Particles; Thesaurus Term: Beryllium; Thesaurus Term: Cellular immunity; Subject Term: Macrophages; Subject Term: Chronic diseases; Author-Supplied Keyword: σ g, geometric standard deviation; Author-Supplied Keyword: σ, ln(σ g); Author-Supplied Keyword: , mass fraction remaining from a log-normally distributed population of homogeneous particles; Author-Supplied Keyword: ABDC, alkylbenzyldimethylammonium chloride; Author-Supplied Keyword: ANOVA, one-way analysis of variance; Author-Supplied Keyword: BeO, beryllium oxide; Author-Supplied Keyword: CBD, chronic beryllium disease; Author-Supplied Keyword: CMD, count median diameter; Author-Supplied Keyword: Cu2O, copper(I) oxide; Author-Supplied Keyword: CuO, copper(II) oxide; Author-Supplied Keyword: D m, mass median diameter; Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: HCl, hydrochloric acid; Author-Supplied Keyword: ICP-MS, inductively coupled plasma-mass spectroscopy; Author-Supplied Keyword: k, chemical dissolution rate constant; Author-Supplied Keyword: M 0, initial particulate beryllium mass; Author-Supplied Keyword: M D, dissolved beryllium mass; Author-Supplied Keyword: Multi-constituent aerosol; Author-Supplied Keyword: Phagolysosome; Author-Supplied Keyword: PSF, phagolysosomal simulant fluid; Author-Supplied Keyword: SSA, specific surface area; Author-Supplied Keyword: SSAeff, effective SSA; Author-Supplied Keyword: SUF, serum ultrafiltrate; Author-Supplied Keyword: US EPA, United States Environmental Protection Agency; Author-Supplied Keyword: XPS, X-ray photoelectron spectroscopy; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.tiv.2005.06.031
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Alvarado-Ramy, F.
AU - Kuehnert, M. J.
AU - Alonso-Echanove, J.
AU - Sledge, L.
AU - Haley, N. R.
AU - Epstein, J.
AU - Vostal, J.
AU - Pearson, M.
T1 - A multistate cluster of red blood cell transfusion reactions associated with use of a leucocyte reduction filter.
JO - Transfusion Medicine
JF - Transfusion Medicine
Y1 - 2006/02//
VL - 16
IS - 1
M3 - Article
SP - 41
EP - 48
PB - Wiley-Blackwell
SN - 09587578
AB - In 2000, the American Red Cross (ARC) received reports of unusual transfusion reactions of unknown aetiology among patients receiving leucocyte-reduced (LR) red blood cell (RBC) units in multiple distribution regions. We evaluated potential risk factors of reactions among patients who received LR-RBC transfusions. A case–patient was defined as any patient with onset of back pain while receiving an LR-RBC transfusion from 1 January to 25 May 2000. Controls were chosen randomly and selected in a 1:3 case : control ratio from healthcare facilities in which case–patients were transfused. Product-specific risk factors of reactions were further determined through nested case–control study, procedural review of blood collection facility and quality-control-testing record review of product processing. Reaction incidence rates were determined through ARC blood product distribution data by region of blood collection and processing. There were 29 reactions detected in patients who received transfusions in 13 healthcare facilities in five states. Eighteen case–patients and 78 controls were included in the case–control study. In univariate analysis, case–patients were more likely than controls to have a haematologic malignancy, to have received the transfusion as an outpatient, to have received an RBC transfusion within the previous 3 months, to have received medication used to prevent reactions or to diminish their intensity upon transfusion (i.e. premedication) or to have received LR-RBC units prepared with the HemaSure r\LS System™ (HS) rather than two other filters used. In multivariate analysis limited to recipients of HS-filtered RBC units, transfusion premedication [adjusted odds ratio (AOR) = 7; 95% confidence interval (CI) 1·4–37; P = 0·02] and transfusion as an outpatient (AOR = 5; 95% CI 1·1–20; P = 0·03) were independently associated with reactions. The rate of reported transfusion reactions was 2·0 reactions per 10 000 RBC units distributed. A multistate cluster of transfusion reactions was significantly associated with leucocyte filtration of RBC units prepared with a specific product, the HS filter. The reactions also were independently associated with premedication and transfusion as an outpatient; these may be surrogates for an increased risk of reaction or for greater likelihood of detection. The mechanism for these reactions has not been elucidated. This cluster of reactions underscores the importance of surveillance efforts to detect adverse events after transfusion, particularly when new methods to modify blood products are introduced. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHROCYTES -- Transfusion
KW - LEUCOCYTES
KW - BLOOD products
KW - BLOOD collection
KW - BLOOD transfusion
KW - blood safety
KW - leucocyte reduction
KW - transfusion reactions
KW - AMERICAN Red Cross
N1 - Accession Number: 19732110; Alvarado-Ramy, F. 1,2 Kuehnert, M. J. 1; Email Address: mkuehnert@cdc.gov Alonso-Echanove, J. 1 Sledge, L. 3 Haley, N. R. 3 Epstein, J. 4 Vostal, J. 4 Pearson, M. 1; Affiliation: 1: Division of Healthcare Quality Promotion, National Center for Infectious Diseases 2: Epidemic Intelligence Service Branch, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Atlanta, GA 3: American Red Cross Blood Services, Arlington, VA 4: Center for Blood Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Source Info: Feb2006, Vol. 16 Issue 1, p41; Subject Term: ERYTHROCYTES -- Transfusion; Subject Term: LEUCOCYTES; Subject Term: BLOOD products; Subject Term: BLOOD collection; Subject Term: BLOOD transfusion; Author-Supplied Keyword: blood safety; Author-Supplied Keyword: leucocyte reduction; Author-Supplied Keyword: transfusion reactions; Company/Entity: AMERICAN Red Cross; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 4 Charts, 2 Graphs, 1 Map; Document Type: Article
L3 - 10.1111/j.1365-3148.2006.00646.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19732110&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, Richard
T1 - Recent developments in vaccination.
JO - Update
JF - Update
Y1 - 2006/02//
VL - 72
IS - 2
M3 - Article
SP - 71
EP - 77
PB - Elsevier Science
SN - 03015718
AB - The article focuses on recent developments in vaccination. The role of pneumococcal vaccination has recently been emphasised in pandemic flu planning, as flu may be complicated by pneumonia. Shortage of flu vaccine this winter has exercised patients, practices and the Government, with the Health Secretary regrettably blaming general practitioners and the BMA responding in kind. Supplies ran short as manufacturers limited additional supplies to contracted contingency amounts only, with extra supplies coming from Government contingency stocks. The vaccines have fewer contraindications and cause 90 per cent fewer adverse effects compared with the older diphtheria, tetanus and pertussis vaccines.
KW - VACCINATION
KW - INFLUENZA
KW - COMMUNICABLE diseases -- Prevention
KW - PREVENTIVE medicine
KW - PATIENTS
KW - PNEUMONIA
N1 - Accession Number: 19981114; Roberts, Richard 1; Affiliation: 1: Head, Vaccine Preventable Disease Programme, National Public Health Service for Wales; Source Info: Feb2006, Vol. 72 Issue 2, p71; Subject Term: VACCINATION; Subject Term: INFLUENZA; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: PREVENTIVE medicine; Subject Term: PATIENTS; Subject Term: PNEUMONIA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 3 Color Photographs, 1 Chart; Document Type: Article; Full Text Word Count: 1680
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19981114&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 108194434
T1 - Recent developments in vaccination.
AU - Roberts R
Y1 - 2006/02//
N1 - Accession Number: 108194434. Language: English. Entry Date: 20120427. Revision Date: 20150712. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 0410033.
KW - Immunization -- Trends
KW - Bacterial Vaccines
KW - Chickenpox Vaccine
KW - Chickenpox -- Prevention and Control
KW - Drug Therapy, Combination
KW - Influenza Vaccine
KW - Influenza -- Prevention and Control
KW - Pneumonia, Bacterial -- Prevention and Control
SP - 71
EP - 77
JO - Update
JF - Update
JA - UPDATE (0301-5718)
VL - 72
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 0301-5718
AD - Head, Vaccine Preventable Disease Programme, National Public Health Service for Wales
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=108194434&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thorpe, S. J.
AU - Fox, B.
AU - Heath, A. B.
AU - Scott, M.
AU - de Haas, M.
AU - Kochman, S.
AU - Padilla, A.
T1 - An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2006/02//
VL - 90
IS - 2
M3 - Article
SP - 131
EP - 139
PB - Wiley-Blackwell
SN - 00429007
AB - Background and Objectives The aim of this study was to evaluate a lyophilized monoclonal immunoglobulin M (IgM) anti-D preparation for use as an International Standard to specify a recommended minimum acceptable potency of anti-D blood-grouping reagents. Materials and Methods The candidate International Standard (99/836) for specifying the minimum potency of anti-D blood-grouping reagents was evaluated against a wide range of commercial anti-D blood-grouping reagents in an international collaborative study involving 20 laboratories in 13 countries. Laboratories titrated reconstituted 99/836, in parallel with as many commercial anti-D blood-grouping reagents as were available to them, in tube tests according to specified haemagglutination methodology for low-protein (e.g. monoclonal IgM) and high-protein (e.g. polyclonal) reagents. The ratios of the mean end-point titres of the reagents to that of 99/836 within each laboratory were calculated. Results The ratios of the mean titres of the low-protein reagents to the mean titre of 99/836 within a laboratory fell between 0·25 and 2 for 43 of the 45 low-protein anti-D reagents tested (i.e. the potencies of the low-protein reagents compared with 99/836 were between a 1 : 4 dilution of 99/836 to twice as potent as 99/836). The ratios of the mean titres of the high-protein reagents to the mean titre of 99/836 within a laboratory fell within 0·125 and 1 for eight out of the 10 high protein reagents tested. Conclusions By international consensus, a 1 : 3 dilution of reconstituted 99/836 was deemed appropriate to define a recommended minimum acceptable potency of low-protein anti-D blood-grouping reagents. A 1 : 8 dilution of reconstituted 99/836 was deemed appropriate to define a recommended minimum acceptable potency of high-protein anti-D blood-grouping reagents. On the basis of the results presented here, 99/836 was established by the World Health Organization as the 1st International Standard for specifying the minimum potency of anti-D blood-grouping reagents, in tube tests. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FREEZE-drying
KW - STANDARDIZATION
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - CLINICAL medicine
KW - CLINICAL trials
KW - PROTEINS
KW - anti-D grouping reagents
KW - International Standard
KW - potency
N1 - Accession Number: 19448465; Thorpe, S. J. 1,2; Email Address: sthorpe@nibsc.ac.uk Fox, B. 1 Heath, A. B. 1 Scott, M. 3 de Haas, M. 4 Kochman, S. 5 Padilla, A. 6; Affiliation: 1: National Institute for Biological Standards and Control, Potters Bar, Herts, UK 2: Division of Haematology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK 3: International Blood Group Reference Laboratory, Bristol, UK 4: Sanquin Diagnostic Services, Amsterdam, the Netherlands 5: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 6: World Health Organization, Geneva, Switzerland; Source Info: Feb2006, Vol. 90 Issue 2, p131; Subject Term: FREEZE-drying; Subject Term: STANDARDIZATION; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: CLINICAL medicine; Subject Term: CLINICAL trials; Subject Term: PROTEINS; Author-Supplied Keyword: anti-D grouping reagents; Author-Supplied Keyword: International Standard; Author-Supplied Keyword: potency; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1423-0410.2005.00735.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19448465&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106424997
T1 - Employment transitions for clubhouse members.
AU - McKay CE
AU - Johnsen M
AU - Banks S
AU - Stein R
Y1 - 2006/02//
N1 - Accession Number: 106424997. Language: English. Entry Date: 20060414. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9204382.
KW - Employment of Disabled -- Trends
KW - Mental Disorders
KW - Sheltered Workshops
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Massachusetts
KW - P-Value
KW - Prospective Studies
KW - Sex Factors
KW - Human
SP - 67
EP - 74
JO - Work
JF - Work
JA - WORK
VL - 26
IS - 1
PB - IOS Press
AB - Using a longitudinal dataset which followed 2195 individuals employed in 3379 separate job placements over a four-year period, this paper explores movement between the employment supports, [Transitional (TE), Supported (SE), and Independent Employment (IE)], offered by clubhouses. Sixty-four percent of employed members held only one job (N=1395) and 36% held multiple jobs during the study (N=791). Patterns of movement were consistent for transitions between the first and second job and subsequent transitions. Forty-six percent of individuals holding multiple jobs moved from one employment type to another. When movement occurred clubhouse members were significantly more likely to move from employment types offering more supports to those that offer less supports.
SN - 1051-9815
AD - Program for Clubhouse Research, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655; Colleen.McKay@umassmed.edu
U2 - PMID: 16373981.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106424997&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-02742-010
AN - 2006-02742-010
AU - Jarrett, Nicole C.
AU - Adeyemi, Sherry A.
AU - Huggins, Thomas
T1 - Bridging the Gap: Providing Health Care to Newly Released Men.
T3 - Community Voices: Health Care for the Underserved
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2006/02//
VL - 17
IS - 1,Suppl
SP - 70
EP - 80
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Adeyemi, Sherry A., 210 Guilford Ave., Third Floor, Baltimore, MD, US, 21202
N1 - Accession Number: 2006-02742-010. Partial author list: First Author & Affiliation: Jarrett, Nicole C.; Center for Mental Health Services and Criminal Justice Research, Rutgers University, NJ, US. Release Date: 20060619. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Service Needs; Primary Health Care; Prisoners. Minor Descriptor: Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 11. Issue Publication Date: Feb, 2006.
AB - Men who are incarcerated have higher morbidity rates than the general U.S. population and upon release most rely on the public sector to get their medical needs met. However, little is known about the health care needs, service utilization patterns, and costs of providing primary care to released inmates in an ambulatory setting. Using data from a primary care health center for uninsured men, health profiles and service use over a 12-month period is described for men newly released from prison (n = 221). Health care needs and utilization were measured by medical diagnosis and primary care consultation rates. The results show that the newly released men studied had different service use patterns from that of the general population. The average cost of providing care was slightly higher than the center's average cost per individual for a man newly released from prison. The findings demonstrate the need for future research to support program planning of organizations seeking to meet the needs of people newly released from prison. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care needs
KW - released inmates
KW - primary care
KW - prisons
KW - 2006
KW - Health Service Needs
KW - Primary Health Care
KW - Prisoners
KW - Health
KW - 2006
DO - 10.1353/hpu.2006.0008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02742-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22839-001
AN - 2006-22839-001
AU - Tunbridge, E. M.
AU - Weinberger, D. R.
AU - Harrison, P. J.
T1 - A novel protein isoform of catechol O-methyltransferase (COMT): Brain expression analysis in schizophrenia and bipolar disorder and effect of Val¹⁵⁸Met genotype.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2006/02//
VL - 11
IS - 2
SP - 116
EP - 117
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Tunbridge, E. M.
N1 - Accession Number: 2006-22839-001. PMID: 16247488 Partial author list: First Author & Affiliation: Tunbridge, E. M.; Department of Psychiatry, University of Oxford, Oxford, United Kingdom. Release Date: 20061226. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Major Descriptor: Bipolar Disorder; Catecholamines; Genotypes; Prefrontal Cortex; Schizophrenia. Minor Descriptor: Brain; Cognitive Impairment; Immunoreactivity. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Feb, 2006.
AB - Recent studies, including several in this journal, have revived interest in the catecholamine metabolising enzyme catechol-O-methyltransferase (COMT), and suggest strongly that it is involved in the dopaminergic regulation of the prefrontal cortex (PFC), and its dysfunction in schizophrenia. These effects are mediated, at least in part, by the Val¹⁵⁸Met polymorphism which influences the activity of the enzyme, and are probably modified by other variables, including the expression of soluble (S-COMT) and membrane-bound (MB-COMT) isoforms. There was a trend effect of Val¹⁵⁸Met genotype on the relative immunoreactivity of the bands (F2,43 = 3.1; P < 0.1), with a significant difference between the homozygote groups. The data suggest that MB-COMT exists in two forms, which may be differentially affected by the Val¹⁵⁸Met genotype and differentially regulated in psychiatric disorders. In summary, the finding of a putative new isoform reveals a hitherto unexplored area of COMT biology which may be relevant to its involvement in schizophrenia and bipolar disorder, and potentially to the use of COMT inhibitors in ameliorating their cognitive deficits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - protein isoform
KW - catechol o methyltransferase
KW - brain expression analysis
KW - schizophrenia
KW - bipolar disorder
KW - prefrontal cortex
KW - 2006
KW - Bipolar Disorder
KW - Catecholamines
KW - Genotypes
KW - Prefrontal Cortex
KW - Schizophrenia
KW - Brain
KW - Cognitive Impairment
KW - Immunoreactivity
KW - 2006
DO - 10.1038/sj.mp.4001767
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22839-001&site=ehost-live&scope=site
UR - elizabeth.tunbridge@psych.ox.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-01851-001
AN - 2006-01851-001
AU - McDowell, T. W.
AU - Wiker, S. F.
AU - Dong, R. G.
AU - Welcome, D. E.
AU - Schopper, A. W.
T1 - Evaluation of psychometric estimates of vibratory hand-tool grip and push forces.
JF - International Journal of Industrial Ergonomics
JO - International Journal of Industrial Ergonomics
JA - Int J Ind Ergon
Y1 - 2006/02//
VL - 36
IS - 2
SP - 119
EP - 128
CY - Netherlands
PB - Elsevier Science
SN - 0169-8141
AD - McDowell, T. W., National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Engineering & Control Technology Branch, 1095 Willowdale Road, MS 2027, Morgantown, WV, US, 26505
N1 - Accession Number: 2006-01851-001. Partial author list: First Author & Affiliation: McDowell, T. W.; National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Engineering & Control Technology Branch, Morgantown, WV, US. Release Date: 20060428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hand (Anatomy); Motor Processes; Psychometrics; Psychophysics; Vibration. Minor Descriptor: Recall (Learning). Classification: Motor Processes (2330); Human Factors Engineering (4010). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Feb, 2006.
AB - Tool grip and push forces are important determinants of health risk associated with operation of powered hand tools. In the field, use of sophisticated hand-force instrumentation can be impractical. This study investigated the potential for using psychophysical force recall methods to estimate grip and push forces when operating vibratory hand tools. This study examined various combinations of handle vibration and grip and push force exposures upon one's ability to recall those forces using psychophysical methods. Twelve male subjects grasped and pushed an instrumented handle for 45 s at one of three levels of force while it vibrated sinusoidally at one of five frequencies (0, 12.5, 40, 125, or 250 Hz). We examined the effects of post-exertion rest periods of 10 and 20 s upon force recall performance, and day-to-day test-retest reliability. Results showed vibration frequency and force level differentially influenced grip and push force recall accuracy. Subjects characteristically overestimated grip and push forces; especially during vibration exposures of 40 and 125 Hz. The magnitude of the overestimations increased as target force levels decreased. Test-retest correlations were reasonably strong. Relevance to industry: Operators of powered hand tools are at risk of developing health problems associated with repeated forceful actions and exposure to intense hand-transmitted vibration. To better assess health risks, hand-tool coupling forces should be quantified. Psychophysical force recall techniques may permit assessment of these forces without the need for expensive or fragile instrumentation. An understanding of the effects of vibration and force level upon force recall accuracy and reliability must first be explored before such methods are proposed for research or field assessments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychometric estimates evaluation
KW - vibratory hand tool grip
KW - push forces
KW - force recall techniques
KW - psychophysics
KW - 2006
KW - Hand (Anatomy)
KW - Motor Processes
KW - Psychometrics
KW - Psychophysics
KW - Vibration
KW - Recall (Learning)
KW - 2006
DO - 10.1016/j.ergon.2005.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-01851-001&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-2416-2210
UR - TMcDowell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-01341-001
AN - 2006-01341-001
AU - Yucesoy, Berran
AU - Peila, Rita
AU - White, Lon R.
AU - Wu, Kim Ming
AU - Johnson, Victor J.
AU - Kashon, Michael L.
AU - Luster, Michael I.
AU - Launer, Lenore J.
T1 - Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: The Honolulu-Asia Aging Study.
JF - Neurobiology of Aging
JO - Neurobiology of Aging
JA - Neurobiol Aging
Y1 - 2006/02//
VL - 27
IS - 2
SP - 211
EP - 217
CY - Netherlands
PB - Elsevier Science
SN - 0197-4580
AD - Yucesoy, Berran, Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, US, 26505
N1 - Accession Number: 2006-01341-001. PMID: 16226351 Partial author list: First Author & Affiliation: Yucesoy, Berran; Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20060424. Correction Date: 20140519. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Genes; Interleukins; Polymorphism; Vascular Dementia. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Cognitive Abilities Screening Instrument DOI: 10.1037/t28521-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 2006.
AB - The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1α, IL-β and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n=931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1β (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1α (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1β (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - interleukin-1 gene polymorphisms
KW - vascular dementia
KW - 2006
KW - Genes
KW - Interleukins
KW - Polymorphism
KW - Vascular Dementia
KW - 2006
U1 - Sponsor: Intramural Research Program of the National Institutes of Health. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging. Grant: N01-AG-4-2149; UO1- AG-0-19349-03; RO1-AG-0-7155-06A1. Recipients: No recipient indicated
U1 - Sponsor: National Heart Lung and Blood Institute. Grant: N01-HC-0-5102. Recipients: No recipient indicated
U1 - Sponsor: Alzheimer's Disease Association. Grant: 20303. Recipients: No recipient indicated
DO - 10.1016/j.neurobiolaging.2005.01.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-01341-001&site=ehost-live&scope=site
UR - byucesoy@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02183-035
AN - 2006-02183-035
AU - Davis, Maryann
T1 - Review of The development and treatment of girlhood aggression.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/02//
VL - 57
IS - 2
SP - 281
EP - 281
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-02183-035. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060320. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Aggressive Behavior; Aggressiveness; Childhood Development; Human Females. Minor Descriptor: Treatment. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Female (40). Reviewed Item: Pepler, Debra (Ed); Madsen, Kirsten (Ed); Webster, Christopher (Ed); Levene, Katrhyn (Ed). The development and treatment of girlhood aggression=Mahwah, New Jersey, Lawrence Erlbaum Associates, 2003, 256 pages, $69.95; 2003. Page Count: 1. Issue Publication Date: Feb, 2006.
AB - Reviews the book, The Development and Treatment of Girlhood Aggression edited by Debra Pepler et al. (2003). The book is organized into five sections, each with two research chapters and a concluding commentary chapter. Each section includes a focus, developmental and measurement issues, physical aggression, social context, treatment aspects, and outcomes among young adults. The final chapters, emphasizing young adult functioning, particularly as it relates to parenting the next generation, provides some of the most compelling reasons for expanded research in this area. Some of the most intriguing chapters include the finding that physical aggression, when carefully measured on the basis of concretely observable forms. However, although these and other authors submit that it is also important to reduce social aggression, they fail to demonstrate its impact on either the perpetrator or the victim and, in fact, provide data suggesting that socially aggressive girls are educationally more successful. Of particular interest is the finding that although girlhood aggression was found to predict numerous subsequent difficulties, the group at the highest risk was girls who were highly aggressive and socially withdrawn. Overall, this is a very useful and thought-provoking book for both clinicians and researchers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - girlhood aggression
KW - development
KW - treatment
KW - 2006
KW - Adolescent Development
KW - Aggressive Behavior
KW - Aggressiveness
KW - Childhood Development
KW - Human Females
KW - Treatment
KW - 2006
U2 - Pepler, Debra (Ed); Madsen, Kirsten (Ed); Webster, Christopher (Ed); Levene, Katrhyn (Ed). (2003); The development and treatment of girlhood aggression; Mahwah, New Jersey, Lawrence Erlbaum Associates, 2003, 256 pages, $69.95
DO - 10.1176/appi.ps.57.2.281
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02183-035&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02226-009
AN - 2006-02226-009
AU - Szarfman, Ana
AU - Doraiswamy, P. Murali
AU - Tonning, Joseph M.
AU - Levine, Jonathan G.
T1 - Association Between Pathologic Gambling and Parkinsonian Therapy as Detected in the Food and Drug Administration Adverse Event Database.
JF - Archives of Neurology
JO - Archives of Neurology
JA - Arch Neurol
Y1 - 2006/02//
VL - 63
IS - 2
SP - 299
EP - 300
CY - US
PB - American Medical Association
SN - 0003-9942
SN - 1538-3687
AD - Szarfman, Ana, Center for Drug Evaluation and Research, Food and Drug Administration, HFD-030, Bldg 22, 10903 New Hampshire Ave, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2006-02226-009. PMID: 16476828 Other Journal Title: A.M.A. Archives of Neurology; JAMA Neurology. Partial author list: First Author & Affiliation: Szarfman, Ana; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, US. Release Date: 20060522. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Etiology; Parkinson's Disease; Pathological Gambling; Side Effects (Drug). Minor Descriptor: Dopamine Agonists; Medical Treatment (General); Parkinsonism; Postsurgical Complications. Classification: Neurological Disorders & Brain Damage (3297); Clinical Psychopharmacology (3340). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Feb, 2006.
AB - Comments on the article by Dodd et al. (see record [rid]2005-11276-001[/rid]). We are expanding the Dodd et al. findings of 11 patients with pathologic gambling associated with drugs prescribed to treat Par- Parkinson disease with data from the Food and Drug Administration Adverse Event Reporting System (AERS) database. Analyses of spontaneous reports can be affected by many biases such as ascertainment bias, concomitant conditions, underreporting, and overreporting. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Parkinson disease
KW - pathological gambling
KW - drugs
KW - potential complication
KW - etiology
KW - medical therapy
KW - 2006
KW - Drug Therapy
KW - Etiology
KW - Parkinson's Disease
KW - Pathological Gambling
KW - Side Effects (Drug)
KW - Dopamine Agonists
KW - Medical Treatment (General)
KW - Parkinsonism
KW - Postsurgical Complications
KW - 2006
DO - 10.1001/archneur.63.2.299-b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02226-009&site=ehost-live&scope=site
UR - szarfman@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-01476-003
AN - 2006-01476-003
AU - Torsheim, Torbjørn
AU - Ravens-Sieberer, Ulrike
AU - Hetland, Jorn
AU - Välimaa, Raili
AU - Danielson, Mia
AU - Overpeck, Mary
T1 - Cross-national variation of gender differences in adolescent subjective health in Europe and North America.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2006/02//
VL - 62
IS - 4
SP - 815
EP - 827
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Torsheim, Torbjørn, Research Centre for Health Promotion, University of Bergen, Christiesgt. 13, N-5015, Bergen, Norway
N1 - Accession Number: 2006-01476-003. PMID: 16098649 Partial author list: First Author & Affiliation: Torsheim, Torbjørn; Research Centre for Health Promotion, University of Bergen, Bergen, Norway. Release Date: 20060428. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cross Cultural Differences; Health Complaints; Human Sex Differences. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: Europe; North America. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: HBSC Symptom Checklist; Family Affluence Scale; Children Symptom Checklist. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Feb, 2006.
AB - The cross-national consistency and variation of gender differences in subjective health complaints was examined in a sample of 125732 11- to 15-year-olds from 29 European and North American countries, participating in the WHO collaborative study Health behaviour in school-aged children (HBSC) 1997/98. Health complaints were measured with the Health Behaviour in School-aged Children Symptom Checklist. Gender differences in health complaints were analysed through multilevel logistic regression analysis. The results indicated a very robust pattern of increasing gender differences across age, with 15-year-old girls as a group at increased risk for health complaints across all countries. The magnitude of gender differences varied across countries, with some countries showing a consistently strong gender difference across age group and different health complaints, and other countries showing a consistently weak gender difference. The gender difference in health complaints was stronger in countries with a low gender development index score. The findings underscore the need to incorporate socio-contextual factors in the study of gender health inequalities during adolescence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cross national variation
KW - gender differences
KW - adolescent subjective health
KW - Europe
KW - North America
KW - subjective health complaints
KW - 2006
KW - Cross Cultural Differences
KW - Health Complaints
KW - Human Sex Differences
KW - 2006
DO - 10.1016/j.socscimed.2005.06.047
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-01476-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0001-7825-4463
UR - torbjoern.torsheim@psyhp.uib.no
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106423597
T1 - Bridging the gap: providing health care to newly released men.
AU - Jarrett NC
AU - Adeyemi SA
AU - Huggins T
Y1 - 2006/02/02/2006 Supplement
N1 - Accession Number: 106423597. Language: English. Entry Date: 20060407. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2006 Supplement. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. NLM UID: 9103800.
KW - Primary Health Care
KW - Public Offenders
KW - Adult
KW - Health Care Costs
KW - Health Services -- Utilization
KW - Male
KW - Maryland
KW - Medically Uninsured
KW - Middle Age
KW - Prisoners
KW - Public Sector
KW - Referral and Consultation
SP - 70
EP - 80
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 17
IS - 1
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - We explored 251 providers' (47% licensed practical nurses, 27% registered nurses, 10% physicians, 10% physician assistants, 6% other) perceptions of barriers to effective management of hypertension and hyperlipidemia from 72 Midwest community health centers (CHCs). Optimal care for these diseases is difficult in any setting; little is known about the specific barriers CHCs face. Community health centers often have a multidisciplinary team that participates in patient care. Current models of quality improvement and chronic care management require virtually all CHC providers to know clinical guidelines. Providers in this study generally chose hypertension and hyperlipidemia target levels that met or were more stringent than national guidelines, but lacked confidence to address behavioral change and reported obstacles to modifying patient lifestyle. Community health centers should strengthen providers' skills in facilitating lifestyle change. Improving quality of care requires supporting providers' efforts to take patients' psychosocial and financial challenges into account, and revised policies to eliminate financial and cultural barriers to care.
SN - 1049-2089
AD - Post-Doctoral Fellow, Center for Mental Health Services and Criminal Justice Research, Rutgers University
U2 - PMID: 16520514.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106423597&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McNamara, Peggy
T1 - Foreword: Payment Matters? The Next Chapter.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2006/02/02/Feb2006 Supplement
VL - 63
M3 - Article
SP - 5S
EP - 10S
SN - 10775587
AB - Presents a foreword to the February 2006 issue of "Medical Care Research and Review" journal.
KW - PREFACES & forewords
KW - MEDICAL care -- Research
N1 - Accession Number: 20998993; McNamara, Peggy 1; Email Address: pmcnamar@ahrq.gov; Affiliation: 1: Senior Policy Analyst, U.S. Agency for Healthcare Research and Quality; Source Info: Feb2006 Supplement, Vol. 63, p5S; Subject Term: PREFACES & forewords; Subject Term: MEDICAL care -- Research; Number of Pages: 6p; Document Type: Article
L3 - 10.1177/1077558705283651
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20998993&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106243186
T1 - Foreword: payment matters? The next chapter.
AU - McNamara P
AU - McNamara, Peggy
Y1 - 2006/02/02/Feb2006 Supplement
N1 - Accession Number: 106243186. Language: English. Entry Date: 20070302. Revision Date: 20170224. Publication Type: journal article. Supplement Title: Feb2006 Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9506850.
KW - Health Care Delivery
KW - Insurance, Health, Reimbursement
KW - Quality of Health Care
KW - Health Care Costs
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 5S
EP - 10S
JO - Medical Care Research & Review
JF - Medical Care Research & Review
JA - MED CARE RES REV
VL - 63
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1077-5587
AD - US Agency for Healthcare Research and Quality, USA
AD - US Agency for Healthcare Research and Quality, USA. pmcnamar@ahrq.gov
U2 - PMID: 16688921.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106243186&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106334552
T1 - Adopting orphan drugs -- two dozen years of treating rare diseases.
AU - Haffner ME
Y1 - 2006/02/02/
N1 - Accession Number: 106334552. Language: English. Entry Date: 20060915. Revision Date: 20150711. Publication Type: Journal Article; commentary; tables/charts. Original Study: Arnon SS, Schechter R, Maslanka SE, Jewell NP, Hatheway CL. Human botulism immune globulin for the treatment of infant botulism. (N ENGL J MED) 2/2/2006; 354 (5): 462-471. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Disease -- Drug Therapy
KW - Drugs, Orphan -- Legislation and Jurisprudence
KW - Clinical Trials
KW - Drug Approval
KW - Drugs, Orphan -- History
KW - Economics, Pharmaceutical
KW - Research Priorities
KW - United States
KW - United States Food and Drug Administration
SP - 445
EP - 447
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 354
IS - 5
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Director, Office of Orphan Products Development, Food and Drug Administration, Rockville, MD
U2 - PMID: 16452556.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106334552&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Frank, Lesley R.
T1 - The Fair and Balanced Road of DTC.
JO - Pharmaceutical Executive
JF - Pharmaceutical Executive
Y1 - 2006/02/02/Feb2006 Supplement Handbook
M3 - Article
SP - 20
EP - 21
PB - Advanstar Communications Inc.
SN - 02796570
N1 - Accession Number: 19983483; Frank, Lesley R. 1; Email Address: frankl@cderfda.gov; Affiliations: 1: Senior advisor regulatory counsel, Division of Drug Marketing, Advertising, and Communications (DDMAC), Center for Drug Evaluation and Research (CDER), FDA; Issue Info: Feb2006 Supplement Handbook, p20; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=19983483&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Jung, Hoi Jong
AU - Kim, Pyoung Il
AU - Lee, Seung Kyu
AU - Lee, Chul Won
AU - Eu, Young-Jae
AU - Lee, Dong Gun
AU - Earm, Yung-E
AU - Kim, Jae Il
T1 - Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2006/02/10/
VL - 340
IS - 2
M3 - Article
SP - 633
EP - 638
SN - 0006291X
AB - Abstract: GsMTx-4, a polypeptide from the spider Grammostola spatulata, is an inhibitor of mechanosensitive channels. It is known to interact with lipid membranes, suggesting it partitions into the membrane to alter the channel gating, but the effect of the membrane charge on GsMTx-4 activity remains unknown. In this study, we found that GsMTx-4 more effectively interacts with anionic lipids than zwitterionic ones. The effect of GsMTx-4 on negatively charged membranes was similar to that of the antimicrobial peptide melittin, which led us to assess GsMTx-4’s antimicrobial activity. Interestingly, we found that, in contrast to other neurotoxins, GsMTx-4 exhibited antimicrobial properties and was more active against Gram-positive than Gram-negative bacteria. These results suggest that GsMTx-4 exerts its antimicrobial effect by altering the packing of the membrane and/or inhibiting mechanosensitive channels. These findings could point the way towards a new class of antimicrobial peptides. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAMMOSTOLA
KW - GRAM-negative bacteria
KW - BIOLOGICAL membranes
KW - AEROMONADACEAE
KW - Antimicrobial peptide
KW - Channel inhibitor
KW - GsMTx-4
KW - Mechanosensitive channel
N1 - Accession Number: 19357996; Jung, Hoi Jong 1 Kim, Pyoung Il 2 Lee, Seung Kyu 1 Lee, Chul Won 1 Eu, Young-Jae 1 Lee, Dong Gun 3 Earm, Yung-E 4 Kim, Jae Il 1; Email Address: jikim@gist.ac.kr; Affiliation: 1: Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, 500-712, Republic of Korea 2: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA 3: School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Taegu 702-701, Republic of Korea 4: Department of Physiology, Seoul National University, College of Medicine, 28 Yonkeun-Dong, Chongno-Ku, Seoul 110-799, Republic of Korea; Source Info: Feb2006, Vol. 340 Issue 2, p633; Subject Term: GRAMMOSTOLA; Subject Term: GRAM-negative bacteria; Subject Term: BIOLOGICAL membranes; Subject Term: AEROMONADACEAE; Author-Supplied Keyword: Antimicrobial peptide; Author-Supplied Keyword: Channel inhibitor; Author-Supplied Keyword: GsMTx-4; Author-Supplied Keyword: Mechanosensitive channel; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bbrc.2005.12.046
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19357996&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor, Deborah R.
T1 - Obstacles and advances in SARS vaccine development
JO - Vaccine
JF - Vaccine
Y1 - 2006/02/13/
VL - 24
IS - 7
M3 - Article
SP - 863
EP - 871
SN - 0264410X
AB - Abstract: The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Virus diseases
KW - Public health
KW - Preventive medicine
KW - Animal models
KW - Coronavirus
KW - SARS-CoV
KW - Severe acute respiratory syndrome
KW - Vaccine
N1 - Accession Number: 19591831; Taylor, Deborah R. 1; Email Address: taylord@cber.fda.gov; Affiliations: 1: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration, 8800 Rockville Pike, HFM-310, Bethesda, MD 20892, USA; Issue Info: Feb2006, Vol. 24 Issue 7, p863; Thesaurus Term: Vaccination; Thesaurus Term: Virus diseases; Thesaurus Term: Public health; Subject Term: Preventive medicine; Author-Supplied Keyword: Animal models; Author-Supplied Keyword: Coronavirus; Author-Supplied Keyword: SARS-CoV; Author-Supplied Keyword: Severe acute respiratory syndrome; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.08.102
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19591831&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chunliu Zhan
AU - Hicks, Rodney W.
AU - Blanchette, Christopher M.
AU - Keyes, Margaret A.
AU - Cousins, Diane D.
T1 - Potential benefits and problems with computerized prescriber order entry: Analysis of a voluntary medication error-reporting database.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2006/02/15/
VL - 63
IS - 4
M3 - Article
SP - 353
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The potential benefits and problems associated with computerized prescriber-order-entry (CPOE) systems were studied. Methods. A national voluntary medication error-reporting database, Medmarx, was used to compare facilities that had CPOE with those that did not have CPOE. The characteristics of medication errors reportedly caused by CPOE were explored, and the text descriptions of these errors were qualitatively analyzed. Results. Facilities with CPOE reported fewer inpatient medication errors and more outpatient medication errors than facilities without CPOE, but the statistical significance of these differences could not be determined. Facilities with CPOE less frequently reported medication errors that reached patients (p < 0.01) or harmed patients (p < 0.01). More than 7000 CPOE-related medication errors were reported over seven months in 2003, and about 0.1% of them resulted in harm or adverse events. The most common CPOE errors were dosing errors (i.e., wrong dose, wrong dosage form, or extra dose). Both quantitative and qualitative analyses indicate that CPOE could lead to medication errors not only because of faulty computer interface, mis-communication with other systems, and lack of adequate decision support but also because of common human errors such as knowledge deficit, distractions, inexperience, and typing errors. Conclusion. A national, voluntary medication error-reporting database cannot be used to determine the effectiveness of a CPOE system in reducing medication errors because of the variability in the number of reports from different institutions. However, it may provide valuable information on the specific types of errors related to CPOE systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACY -- Information services
KW - PHARMACEUTICAL services
KW - DATABASES
KW - MANAGEMENT information systems
KW - DOSAGE forms of drugs
KW - MEDICATION errors
KW - Computers
KW - Databases
KW - Dosage
KW - Dosage forms
KW - Errors
KW - Errors, medication
KW - medication
KW - Medication orders
KW - Physicians
KW - Reports
KW - Toxicity
N1 - Accession Number: 19600936; Chunliu Zhan 1; Email Address: czhan@ahrq.gov Hicks, Rodney W. 2 Blanchette, Christopher M. 3 Keyes, Margaret A. 4 Cousins, Diane D. 5; Affiliation: 1: Senior Service Fellow, Agency for Healthcare Research and Quality (AHRQ), Rockville, MD 2: Research Coordinator, Center for the Advancement of Patient Safety, United States Pharmacopeia (USP), Rockville 3: Research Associate, School of Pharmacy, University of Maryland, Baltimore 4: Team Leader, Patient Safety 5: Vice President, Center for the Advancement of Patient Safety, USP; Source Info: 2/15/2006, Vol. 63 Issue 4, p353; Subject Term: PHARMACY -- Information services; Subject Term: PHARMACEUTICAL services; Subject Term: DATABASES; Subject Term: MANAGEMENT information systems; Subject Term: DOSAGE forms of drugs; Subject Term: MEDICATION errors; Author-Supplied Keyword: Computers; Author-Supplied Keyword: Databases; Author-Supplied Keyword: Dosage; Author-Supplied Keyword: Dosage forms; Author-Supplied Keyword: Errors; Author-Supplied Keyword: Errors, medication; Author-Supplied Keyword: medication; Author-Supplied Keyword: Medication orders; Author-Supplied Keyword: Physicians; Author-Supplied Keyword: Reports; Author-Supplied Keyword: Toxicity; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.2146/ajhp050379
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19600936&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106316175
T1 - Potential benefits and problems with computerized prescriber order entry: analysis of a voluntary medication error-reporting database.
AU - Zhan C
AU - Hicks RW
AU - Blanchette CM
AU - Keyes MA
AU - Cousins DD
Y1 - 2006/02/15/
N1 - Accession Number: 106316175. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Databases
KW - Electronic Order Entry
KW - Medication Errors -- Evaluation
KW - Medication Systems
KW - Voluntary Reporting
KW - Chi Square Test
KW - Comparative Studies
KW - Convenience Sample
KW - Descriptive Research
KW - Descriptive Statistics
KW - Evaluation Research
KW - Medication Errors -- Classification
KW - Medication Errors -- Epidemiology
KW - Medication Errors -- Etiology
KW - Prescriptions, Drug
KW - T-Tests
KW - United States
KW - Human
SP - 353
EP - 358
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 63
IS - 4
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - PURPOSE: The potential benefits and problems associated with computerized prescriber-order-entry (CPOE) systems were studied. METHODS: A national voluntary medication error-reporting database, Medmarx, was used to compare facilities that had CPOE with those that did not have CPOE. The characteristics of medication errors reportedly caused by CPOE were explored, and the text descriptions of these errors were qualitatively analyzed. RESULTS: Facilities with CPOE reported fewer inpatient medication errors and more outpatient medication errors than facilities without CPOE, but the statistical significance of these differences could not be determined. Facilities with CPOE less frequently reported medication errors that reached patients (p < 0.01) or harmed patients (p < 0.01). More than 7000 CPOE-related medication errors were reported over seven months in 2003, and about 0.1% of them resulted in harm or adverse events. The most common CPOE errors were dosing errors (i.e., wrong dose, wrong dosage form, or extra dose). Both quantitative and qualitative analyses indicate that CPOE could lead to medication errors not only because of faulty computer interface, mis-communication with other systems, and lack of adequate decision support but also because of common human errors such as knowledge deficit, distractions, inexperience, and typing errors. CONCLUSION: A national, voluntary medication error-reporting database cannot be used to determine the effectiveness of a CPOE system in reducing medication errors because of the variability in the number of reports from different institutions. However, it may provide valuable information on the specific types of errors related to CPOE systems.
SN - 1079-2082
AD - Senior Service Fellow, Agency for Healthcare Research and Quality, Rockville, MD 20850; czhan@ahrq.gov
U2 - PMID: 16452521.
DO - 10.2146/ajhp050379
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106316175&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106316181
T1 - Effect on health outcomes of a community-based medication therapy management program for seniors with limited incomes.
AU - Smith SR
AU - Catellier DJ
AU - Conlisk EA
AU - Upchurch GA
Y1 - 2006/02/15/
N1 - Accession Number: 106316181. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. Grant Information: Funded in part by a grant from the Robert Wood Johnson Foundation Community Health Leadership Program. NLM UID: 9503023.
KW - Community Health Services -- In Old Age
KW - Drugs, Prescription -- In Old Age
KW - Health Services Accessibility -- In Old Age
KW - Health Services for the Aged
KW - Health Status -- In Old Age
KW - Poverty -- In Old Age
KW - Activities of Daily Living -- Evaluation
KW - Aged
KW - Aged, 80 and Over
KW - Conceptual Framework
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Emergency Service -- Utilization
KW - Female
KW - Funding Source
KW - Geriatric Functional Assessment
KW - Health Status -- Evaluation
KW - Hospitalization -- Trends
KW - Linear Regression
KW - Male
KW - Models, Theoretical
KW - Pharmacists
KW - Professional Role
KW - Program Evaluation
KW - Research Instruments
KW - Self Report
KW - Human
SP - 372
EP - 379
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 63
IS - 4
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Senior Service Fellow and Director of Pharmaceutical Outcomes Research, Agency for Healthcare Research and Quality, Rockville, MD; ssmith@ahrq.gov
U2 - PMID: 16452523.
DO - 10.2146/ajhp050089
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106316181&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - White, P. Lewis
AU - Linton, Christopher J.
AU - Perry, Michael D.
AU - Johnson, Elizabeth M.
AU - Barnes, Rosemary A.
T1 - The Evolution and Evaluation of a Whole Blood Polymerase Chain Reaction Assay for the Detection of Invasive Aspergillosis in Hematology Patients in a Routine Clinical Setting.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/02/15/
VL - 42
IS - 4
M3 - Article
SP - 479
EP - 486
SN - 10584838
AB - Background. Invasive aspergillosis (IA) is associated with high mortality. Successful outcome with treatment is linked to early diagnosis. The utility of classic diagnostic methods, however, is limited. Methods. To aid in the diagnosis of IA, we retrospectively assessed our diagnostic service, using real-time polymerase chain reaction (PCR) and galactomannan sandwich enzyme-linked immunosorbent assay (ELISA). Results. A total of 203 patients at risk of invasive fungal infection were screened by PCR, and 116 of the patients were also tested by ELISA. The patient group comprised 176 patients with hematological malignancy and 28 control patients with evidence of invasive candidal infection. Consensus European Organisation for Research and Treatment of Cancer and Mycoses Study Group criteria were used to classify fungal infection, which, by definition, excluded the PCR result. The PCR method was sensitive (up to 92.3% sensitivity) and specific (up to 94.6% specificity) and had good agreement with the galactomannan ELISA (76.7%) and high-resolution computed tomography scan results. Conclusions. A negative PCR result can be used to rule out IA and to limit the need for empirical antifungal therapy', thus, it has a role in diagnosing IA infections, especially in combination with antigen testing. PCR-positive cases classified as "false positives" regularly reflect the limitations of classic microbiological procedures or restricted use of consensus clinical methods employed to classify infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycoses
KW - Aspergillosis
KW - Polymerase chain reaction
KW - Blood
KW - Hematology
KW - Diagnosis
N1 - Accession Number: 19737563; White, P. Lewis 1; Email Address: Lewis.White@nphs.wales.nhs.uk; Linton, Christopher J. 2; Perry, Michael D. 1; Johnson, Elizabeth M. 2; Barnes, Rosemary A. 1; Affiliations: 1: Department of Medical Microbiology and National Public Health Service Cardiff, University Hospital of Wales, Cardiff, United Kingdom.; 2: Mycology Reference Laboratory, Health Protection Agency, Southwest Regional Laboratory, Bristol, United Kingdom.; Issue Info: 2/15/2006, Vol. 42 Issue 4, p479; Thesaurus Term: Mycoses; Subject Term: Aspergillosis; Subject Term: Polymerase chain reaction; Subject Term: Blood; Subject Term: Hematology; Subject Term: Diagnosis; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Waibel, Kirk H.
AU - Golding, Hana
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Tuchscherer, Margaret
AU - Topolski, Richard L.
AU - Walsh, Douglas S.
T1 - Clinical and Immunological Comparison of Smallpox Vaccine Administered to the Outer versus the Inner Upper Arms of Vaccinia-Naive Adults.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/02/15/
VL - 42
IS - 4
M3 - Article
SP - e16
EP - e20
SN - 10584838
AB - Background. Current recommendations direct health care providers to administer smallpox vaccine to the upper outer arm. However, concerns about cosmetically bothersome scarring, accidental contact transmission, interference by body tattoos, and even malignant transformation suggest evaluation of alternate vaccination sites is warranted. Methods. We randomized 20 vaccinia-naive adults to undergo smallpox vaccination on the outer (n = 10) or inner (n = 10) upper arm. Evaluations included major reaction ("take") rates and vaccination site cultures on postvaccination day 7, determination of serum vaccinia-specific neutralizing antibody titers on days 0 (prevaccination) and 21, and determination of adverse events. Results. On postvaccination day 7, a total of 18 participants (9 per group) had major reactions, 17 of whom had culture evidence of viable vaccinia. The inner and outer arm groups had similar major reaction mean sizes (P = .17), but the amount of erythema (in square centimeters) was smaller in the inner arm group (P = .05). At day 21, all participants had higher titers of vaccinia-specific neutralizing antibodies, compared with at day 0, and the geometric mean titer values of the 2 vaccine groups were similar (P = .45). Adverse event rates were similar. Conclusion. The comparable clinical, immunological, and tolerability outcomes between smallpox vaccine applied to the conventional upper outer arm site versus the upper inner arm, coupled with modestly less vaccine-site erythema on the inner arm, indicate that the inner arm may be a suitable alternate vaccination site. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunization
KW - Vaccination
KW - Public health
KW - Smallpox vaccine
KW - Cancer
KW - Immunoglobulins
N1 - Accession Number: 19737593; Waibel, Kirk H. 1; Email Address: kirk.waibel@se.amedd.army.mil; Golding, Hana 2; Manischewitz, Jody 2; King, Lisa R. 2; Tuchscherer, Margaret 3; Topolski, Richard L. 4; Walsh, Douglas S. 5; Affiliations: 1: Allergy and Immunology Service, Department of Medicine, Augusta, Georgia.; 2: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda.; 3: Department of Pathology, Dwight D. Eisenhower Army Medical Center, Fort Gordon, Augusta, Georgia.; 4: Department of Psychology, Augusta State University, Augusta, Georgia.; 5: Department of Clinical Trials, Walter Reed Army Institute of Research, Silver Spring, Maryland.; Issue Info: 2/15/2006, Vol. 42 Issue 4, pe16; Thesaurus Term: Immunization; Thesaurus Term: Vaccination; Thesaurus Term: Public health; Subject Term: Smallpox vaccine; Subject Term: Cancer; Subject Term: Immunoglobulins; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stultz, Brian G.
AU - Jackson, Donald G.
AU - Mortin, Mark A.
AU - Yang, Xiang
AU - Beachy, Philip A.
AU - Hursh, Deborah A.
T1 - Transcriptional activation by extradenticle in the Drosophila visceral mesoderm
JO - Developmental Biology
JF - Developmental Biology
Y1 - 2006/02/15/
VL - 290
IS - 2
M3 - Article
SP - 482
EP - 494
SN - 00121606
AB - Abstract: decapentaplegic (dpp) is a direct target of Ultrabithorax (Ubx) in parasegment 7 (PS7) of the embryonic visceral mesoderm. We demonstrate that extradenticle (exd) and homothorax (hth) are also required for dpp expression in this location, as well as in PS3, at the site of the developing gastric caecae. A 420 bp element from dpp contains EXD binding sites necessary for expressing a reporter gene in both these locations. Using a specificity swap, we demonstrate that EXD directly activates this element in vivo. Activation does not require Ubx, demonstrating that EXD can activate transcription independently of homeotic proteins. Restoration is restricted to the domains of endogenous dpp expression, despite ubiquitous expression of altered specificity EXD. We demonstrate that nuclear EXD is more extensively phosphorylated than the cytoplasmic form, suggesting that EXD is a target of signal transduction by protein kinases. [Copyright &y& Elsevier]
AB - Copyright of Developmental Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMBRYOLOGY
KW - PROTEINS
KW - TRANSCRIPTION
KW - BIOCHEMISTRY
KW - decapentaplegic (dpp)
KW - Drosophila melanogaster
KW - extradenticle (exd)
KW - homothorax (hth)
KW - Phosphorylation
KW - Transcriptional activation
KW - Ultrabithorax (Ubx)
KW - Visceral mesoderm
N1 - Accession Number: 19593554; Stultz, Brian G. 1 Jackson, Donald G. 2 Mortin, Mark A. 3 Yang, Xiang 4 Beachy, Philip A. 2 Hursh, Deborah A. 1; Email Address: deborah.hursh@fda.hhs.gov; Affiliation: 1: Cellular and Tissue Therapy Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-730, Bldg. 29B, Rm. 1E16, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 3: Laboratory of Biochemistry, National Cancer Institute and Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 4: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Feb2006, Vol. 290 Issue 2, p482; Subject Term: EMBRYOLOGY; Subject Term: PROTEINS; Subject Term: TRANSCRIPTION; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: decapentaplegic (dpp); Author-Supplied Keyword: Drosophila melanogaster; Author-Supplied Keyword: extradenticle (exd); Author-Supplied Keyword: homothorax (hth); Author-Supplied Keyword: Phosphorylation; Author-Supplied Keyword: Transcriptional activation; Author-Supplied Keyword: Ultrabithorax (Ubx); Author-Supplied Keyword: Visceral mesoderm; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.ydbio.2005.11.041
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Uhl, Kathleen
AU - Cox, Edward
AU - Rogan, Rose
AU - Zeldis, Jerome B.
AU - Hixon, Dena
AU - Furlong, Lesley-Anne
AU - Singer, Sarah
AU - Holliman, Tracy
AU - Beyer, Joanne
AU - Woolever, William
T1 - Thalidomide Use in the US: Experience with Pregnancy Testing in the S.T.E.P.S.® Programme.
JO - Drug Safety
JF - Drug Safety
Y1 - 2006/02/15/
VL - 29
IS - 4
M3 - Article
SP - 321
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - INTRODUCTION: In 1998, thalidomide (Thalomid), a known human teratogen, was approved by the US FDA for the treatment of erythema nodosum leprosum. To prevent fetal exposure to thalidomide, a restricted distribution risk management programme, the System for Thalidomide Education and Prescribing Safety (S.T.E.P.S.), was implemented. All clinicians, pharmacists and patients who prescribe, dispense and receive thalidomide, respectively, are required to enrol in S.T.E.P.S.. Sexually active females of childbearing potential must use two methods of birth control before, during and after treatment. These patients must also have a negative pregnancy test within 24 hours before beginning therapy and periodically while on therapy. The objective of this report is to summarise the patterns of thalidomide use and to describe the occurrence of positive pregnancy tests in females of childbearing potential while they were using thalidomide in the S.T.E.P.S. programme in the US. STUDY DESIGN/METHODS: A retrospective review of patients receiving thalidomide within the S.T.E.P.S. programme from September 1998 to 31 December 2004 to determine the occurrence of positive pregnancy tests whilst on treatment. RESULTS: Approximately 124 000 (43% female) patients were registered within the S.T.E.P.S. programme between September 1998 and 31 December 2004. Approximately 6000 patients were females of childbearing potential, representing 5% of all patients and 11% of all female patients. Between 30 July 2001 and 31 December 2004, >88% of thalidomide use was for oncological conditions. There were 72 females of childbearing potential who had positive pregnancy tests. Sixty-nine of these patients had false positive pregnancy tests. Of the remaining three, one woman was pregnant while on thalidomide. This patient had an initial negative test and received thalidomide. Therapy was stopped when she had a positive pregnancy test. This pregnancy resulted in a miscarriage. Two additional patients were determined to be pregnant before receiving thalidomide. CONCLUSIONS: The S.T.E.P.S. programme is critical to managing the risks of thalidomide-associated teratogenicity. Sustained vigilance among healthcare providers and patients receiving thalidomide is essential to its continued success. Healthcare providers should be aware of the occurrence of false-positive pregnancy tests in females of childbearing potential receiving thalidomide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THALIDOMIDE
KW - ERYTHEMA
KW - PREGNANCY
KW - TERATOGENIC agents
KW - HEALTH
KW - MEDICINE
KW - DRUGS -- Effectiveness
KW - PHTHALIC acid
KW - UNITED States
N1 - Accession Number: 20503283; Uhl, Kathleen 1; Email Address: kathleen.uhl@oc.fda.gov Cox, Edward 1 Rogan, Rose 2 Zeldis, Jerome B. 2 Hixon, Dena 1 Furlong, Lesley-Anne 1 Singer, Sarah 1,3 Holliman, Tracy 2 Beyer, Joanne 2 Woolever, William 2; Affiliation: 1: US Food & Drug Administration, Center for Drug Evaluation and Research, Rockville, Maryland, USA 2: Celgene Corporation, Summit, New Jersey, USA 3: National Institutes of Health, National Library of Medicine, Bethesda, Maryland, USA; Source Info: 2006, Vol. 29 Issue 4, p321; Subject Term: THALIDOMIDE; Subject Term: ERYTHEMA; Subject Term: PREGNANCY; Subject Term: TERATOGENIC agents; Subject Term: HEALTH; Subject Term: MEDICINE; Subject Term: DRUGS -- Effectiveness; Subject Term: PHTHALIC acid; Subject Term: UNITED States; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ivanov, Alexander P.
AU - Dragunsky, Eugenia M.
AU - Chumakov, Konstantin M.
T1 - 1,25-Dihydroxyvitamin D3 Enhances Systemic and Mucosal Immune Responses to Inactivated Poliovirus Vaccine in Mice.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/02/15/
VL - 193
IS - 4
M3 - Article
SP - 598
EP - 600
SN - 00221899
AB - 1,25-Dihydroxyvitamin D3 (DHVD3) coadministered with monovalent inactivated poliovirus vaccine (IPV) of all 3 serotypes significantly enhances antipoliovirus systemic and mucosal immunity in mice. Although serum immunoglobulin G antibodies are significantly higher in serotypes 2 and 3, and although salivary immunoglobulin A is significantly increased in serotypes 1 and 3, DHVD3 had the most dramatic effect on the level of neutralizing serum antibodies of all 3 IPV serotypes. These findings suggest a possible use of vitamin D3 as an adjuvant for currently used and proposed new Sabin IPVs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUCOSAL diseases in cattle
KW - IMMUNE response
KW - CHENODEOXYCHOLIC acid
KW - POLIOVIRUS
KW - VACCINATION
KW - MICE
KW - IMMUNOGLOBULINS
N1 - Accession Number: 19737616; Ivanov, Alexander P. 1; Email Address: ivanov@cber.fda.gov Dragunsky, Eugenia M. 1 Chumakov, Konstantin M. 1; Affiliation: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD.; Source Info: 2/15/2006, Vol. 193 Issue 4, p598; Subject Term: MUCOSAL diseases in cattle; Subject Term: IMMUNE response; Subject Term: CHENODEOXYCHOLIC acid; Subject Term: POLIOVIRUS; Subject Term: VACCINATION; Subject Term: MICE; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106347910
T1 - 1,25-dihydroxyvitamin D3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice.
AU - Ivanov AP
AU - Dragunsky EM
AU - Chumakov KM
Y1 - 2006/02/15/
N1 - Accession Number: 106347910. Language: English. Entry Date: 20061013. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: National Vaccine Program Office (grant 224-95-1247).. NLM UID: 0413675.
KW - Enteroviruses -- Immunology
KW - Immunity -- Drug Effects
KW - Poliomyelitis -- Immunology
KW - Poliovirus Vaccine, Inactivated -- Immunology
KW - Vitamin D
KW - Animal Studies
KW - Enteroviruses -- Drug Effects
KW - Funding Source
KW - Mice
KW - Models, Biological
KW - Poliomyelitis -- Blood
KW - Poliomyelitis -- Prevention and Control
KW - Poliovirus Vaccine, Inactivated -- Administration and Dosage
KW - Vitamin D -- Pharmacodynamics
SP - 598
EP - 600
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 193
IS - 4
PB - Oxford University Press / USA
AB - 1,25-Dihydroxyvitamin D3 (DHVD3) coadministered with monovalent inactivated poliovirus vaccine (IPV) of all 3 serotypes significantly enhances antipoliovirus systemic and mucosal immunity in mice. Although serum immunoglobulin G antibodies are significantly higher in serotypes 2 and 3, and although salivary immunoglobulin A is significantly increased in serotypes 1 and 3, DHVD3 had the most dramatic effect on the level of neutralizing serum antibodies of all 3 IPV serotypes. These findings suggest a possible use of vitamin D3 as an adjuvant for currently used and proposed new Sabin IPVs. Copyright © 2006 Infectious Diseases Society of America
SN - 0022-1899
AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852, USA. ivanov@cber.fda.gov
U2 - PMID: 16425140.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gaw, S.K.
AU - Wilkins, A.L.
AU - Kim, N.D.
AU - Palmer, G.T.
AU - Robinson, P.
T1 - Trace element and ΣDDT concentrations in horticultural soils from the Tasman, Waikato and Auckland regions of New Zealand
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2006/02/15/
VL - 355
IS - 1-3
M3 - Article
SP - 31
EP - 47
SN - 00489697
AB - Abstract: The long-term routine use of agrichemicals can result in elevated levels of trace elements and persistent organic pollutants in soils. Trace element concentrations and ΣDDT levels were measured in soil (0–7.5 cm) samples collected from horticultural and grazing properties in 3 regions of New Zealand (Auckland, Tasman and Waikato). Elevated levels of arsenic (<2 to 58 mg kg−1), cadmium (<0.1 to 1.5 mg kg−1), copper (5 to 523 mg kg−1), lead (5 to 243 mg kg−1) and ΣDDT (<0.03 to 34.5 mg kg−1) were detected in soils from all 3 regions. With the exception of cadmium and zinc, significantly higher levels of contaminants were generally detected in horticultural soils than in grazing soils. Our results have implications for the on-going use of agrichemicals as concentrations of cadmium, copper, tin and zinc in some samples exceeded ecotoxicity based soil criteria. The p,p′-DDE:DDT ratios indicate that the degradation of DDT in NZ horticultural soils may be inhibited by the co-contamination with trace elements. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURAL chemicals
KW - HISTOSOLS
KW - POLLUTANTS
KW - ARSENIC
KW - Arsenic
KW - Cadmium
KW - Copper
KW - DDT
KW - Lead
KW - Mercury
KW - New Zealand (NZ)
KW - Orchard soils
KW - Tin
KW - Zinc
N1 - Accession Number: 19594979; Gaw, S.K. 1,2; Email Address: skg3@waikato.ac.nz Wilkins, A.L. 1 Kim, N.D. 3 Palmer, G.T. 1 Robinson, P. 4; Affiliation: 1: University of Waikato, Private Bag 3105, Hamilton, New Zealand 2: Auckland Regional Public Health Service, Auckland District Health Board, Private Bag 92 605, Symonds St., Auckland, New Zealand 3: Environment Waikato, P.O. Box 4010, Hamilton, New Zealand 4: Hill Laboratories, Private Bag 3205, Hamilton, New Zealand; Source Info: Feb2006, Vol. 355 Issue 1-3, p31; Subject Term: AGRICULTURAL chemicals; Subject Term: HISTOSOLS; Subject Term: POLLUTANTS; Subject Term: ARSENIC; Author-Supplied Keyword: Arsenic; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Copper; Author-Supplied Keyword: DDT; Author-Supplied Keyword: Lead; Author-Supplied Keyword: Mercury; Author-Supplied Keyword: New Zealand (NZ); Author-Supplied Keyword: Orchard soils; Author-Supplied Keyword: Tin; Author-Supplied Keyword: Zinc; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.scitotenv.2005.02.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donohue, Maura
AU - Wei, Wei
AU - Wu, Jinfang
AU - Zawia, Nasser H.
AU - Hud, Nicholas
AU - Jesus, Victor De
AU - Schmechel, Detlef
AU - Hettick, Justin M.
AU - Beezhold, Donald H.
AU - Vesper, Stephen
T1 - Characterization of nigerlysin ©, hemolysin produced by Aspergillus niger, and effect on mouse neuronal cells in vitro
JO - Toxicology
JF - Toxicology
Y1 - 2006/02/15/
VL - 219
IS - 1-3
M3 - Article
SP - 150
EP - 155
SN - 0300483X
AB - Abstract: Aspergillus niger produced a proteinaceous hemolysin, nigerlysin © when incubated on sheep''s blood agar (SBA) at both 23 and 37°C. Nigerlysin was purified from tryptic soy broth (TSB) culture filtrate and found to have a molecular weight of approximately 72kDa, with an isoelectric point of 3.45. Nigerlysin is heat stable up to 65°C but unstable at 75°C when incubated for 10min. Circular dichroic analysis revealed that nigerlysin has an alpha helical structure. Exposure of mouse primary cortical neuronal cells to 0.1μgml−1 of nigerlysin resulted in the rapid loss of their viability, approximately 50% in 24h. The IC50 is estimated to be 0.037μgml−1, or between 0.034 and 0.041μgml−1 at the 95% confidence level. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPERGILLUS niger
KW - MICE as laboratory animals
KW - POLYSACCHARIDES
KW - SULFATES
KW - Aspergillus niger
KW - Hemolysin
KW - Neuronal cells
KW - Nigerlysin
N1 - Accession Number: 19469722; Donohue, Maura 1 Wei, Wei 2 Wu, Jinfang 2 Zawia, Nasser H. 2 Hud, Nicholas 3 Jesus, Victor De 4 Schmechel, Detlef 5 Hettick, Justin M. 5 Beezhold, Donald H. 5 Vesper, Stephen 1; Email Address: vesper.stephen@epa.gov; Affiliation: 1: National Exposure Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, OH, USA 2: Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston RI, USA 3: School of Chemistry and Biochemistry, Parker H. Petit Institute of Bioengineering and Biosciences, Atlanta, GA, USA 4: Georgia Tech Research Institute, Georgia Institute of Technology, Atlanta, GA, USA 5: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, Morgantown, WV, USA; Source Info: Feb2006, Vol. 219 Issue 1-3, p150; Subject Term: ASPERGILLUS niger; Subject Term: MICE as laboratory animals; Subject Term: POLYSACCHARIDES; Subject Term: SULFATES; Author-Supplied Keyword: Aspergillus niger; Author-Supplied Keyword: Hemolysin; Author-Supplied Keyword: Neuronal cells; Author-Supplied Keyword: Nigerlysin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.tox.2005.11.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pedro E. M. Lopes
AU - Vladimir Murashov
AU - Mouhsine Tazi
AU - Eugene Demchuk
AU - Alexander D. MacKerell
T1 - Development of an Empirical Force Field for Silica. Application to the Quartz−Water Interface.
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
Y1 - 2006/02/16/
VL - 110
IS - 6
M3 - Article
SP - 2782
EP - 2792
SN - 15206106
AB - Interactions of pulverized crystalline silica with biological systems, including the lungs, cause cell damage, inflammation, and apoptosis. To allow computational atomistic modeling of these pathogenic processes, including interactions between silica surfaces and biological molecules, new parameters for quartz, compatible with the CHARMM empirical force field were developed. Parameters were optimized to reproduce the experimental geometry of α-quartz, ab initio vibrational spectra, and interactions between model compounds and water. The newly developed force field was used to study interactions of water with two singular surfaces of α-quartz, (011) and (100). Properties monitored and analyzed include the variation of the density of water molecules in the plane perpendicular to the surface, disruption of the water H-bond network upon adsorption, and space-time correlations of water oxygen atoms in terms of Van Hove self-correlation functions. The vibrational density of states spectra of water in confined compartments were also computed and compared with experimental neutron-scattering results. Both the attenuation and shifting to higher frequencies of the hindered translational peaks upon confinement are clearly reproduced by the model. However, an upshift of librational peaks under the conditions of model confinement still remains underrepresented at the current empirical level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry B is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - QUARTZ
KW - INTERFACES (Physical sciences)
KW - VIBRATIONAL spectra
N1 - Accession Number: 20487548; Pedro E. M. Lopes 1 Vladimir Murashov 1 Mouhsine Tazi 1 Eugene Demchuk 1 Alexander D. MacKerell 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry (ATSDR/CDC), 1600 Clifton Road NE, F-32, Atlanta, Georgia 30333, and School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; Source Info: Feb2006, Vol. 110 Issue 6, p2782; Subject Term: SILICA; Subject Term: QUARTZ; Subject Term: INTERFACES (Physical sciences); Subject Term: VIBRATIONAL spectra; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schmechel, Detlef
AU - Simpson, Janet P.
AU - Beezhold, Donald
AU - Lewis, Daniel M.
T1 - The development of species-specific immunodiagnostics for Stachybotrys chartarum: The role of cross-reactivity
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2006/02/20/
VL - 309
IS - 1/2
M3 - Article
SP - 150
EP - 159
SN - 00221759
AB - Abstract: Mold contamination and exposure to fungi in indoor environments has been associated with various adverse health effects but little is known about the significance of individual fungal species in the initiation or exacerbation of such effects. Using Stachybotrys chartarum as a model fungus we sought to demonstrate that monoclonal antibodies (mAbs) can provide species-specific diagnostic reagents and also be used to investigate immunological cross-reactivity patterns among fungi. Mice were immunized with S. chartarum spore walls and monoclonal antibodies were screened against 60 fungal species and 24 different isolates of S. chartarum using an indirect ELISA. One species-specific mAb (IgG1) reacted only with spore preparations but not mycelium of S. chartarum or propagules of any other fungus. Five cross-reactive mAbs (IgM) documented extensive cross-reactivity among nine related Stachybotrys species and several non-related genera including several species of Cladosporium, Memnoniella, Myrothecium and Trichoderma. We also found that the ELISA reactivity for cross-reactive antigens and different isolates of S. chartarum differed considerably for normalized total amounts of mycelial antigen. We demonstrate that mAbs and immunoassays have the potential to detect S. chartarum species-specifically. The observed reactivity patterns with cross-reactive mAbs suggest that several fungi may share common antigens and that the majority of antigens are expressed by spores and mycelia. The observed cross-reactivity patterns need to be considered for accurate interpretations of environmental and serological analyses. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ENZYME-linked immunosorbent assay
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULIN M
KW - carbonate coating buffer ( CCB )
KW - ELISA
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - Fungi
KW - Immunological cross-reactivity
KW - Monoclonal antibodies
KW - monoclonal antibody ( mAb )
KW - PBS containing 0.05% Tween 20 ( PBST )
KW - PBST containing 1% non-fat dry milk powder ( PBSTM )
KW - phosphate-buffered saline ( PBS )
KW - room temperature ( RT )
KW - Stachybotrys chartarum
KW - substrate incubation time ( SIT )
N1 - Accession Number: 19697944; Schmechel, Detlef; Email Address: dschmechel@cdc.gov Simpson, Janet P. 1 Beezhold, Donald 1 Lewis, Daniel M. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 1095 Willowdale Road, M/S L-4020, Morgantown, WV 26505, USA; Source Info: Feb2006, Vol. 309 Issue 1/2, p150; Subject Term: IMMUNOGLOBULINS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULIN M; Author-Supplied Keyword: carbonate coating buffer ( CCB ); Author-Supplied Keyword: ELISA; Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Immunological cross-reactivity; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: monoclonal antibody ( mAb ); Author-Supplied Keyword: PBS containing 0.05% Tween 20 ( PBST ); Author-Supplied Keyword: PBST containing 1% non-fat dry milk powder ( PBSTM ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: room temperature ( RT ); Author-Supplied Keyword: Stachybotrys chartarum; Author-Supplied Keyword: substrate incubation time ( SIT ); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jim.2005.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19697944&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowyer, John F.
AU - Schmued, Larry C.
T1 - Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen
JO - Brain Research
JF - Brain Research
Y1 - 2006/02/23/
VL - 1075
IS - 1
M3 - Article
SP - 236
EP - 239
SN - 00068993
AB - Abstract: Fluoro-Ruby (FR) was injected into the substantia nigra (SNc) to label dopaminergic axons and terminals in the caudate putamen (CPu) of rats 7 days prior to a neurotoxic d-amphetamine (AMPH) exposure. Three days after AMPH exposure, a massive loss in the TH immunoreactive (TH+) axons and terminals was seen in the CPu. The FR-labeled (FR+) axons and terminals in the CPu were greatly diminished with those remaining being enlarged or swollen after AMPH. Fluoro-Jade C (FJ-C) labeling was used to verify AMPH-induced axonal and terminal degeneration. This study demonstrates that fluorescent anterograde tract tracers can be used to show the subsequent axonal and terminal degeneration after systemic exposures to toxins and provides direct evidence that CPu axons and terminals from SNc dopaminergic neurons can be destroyed after neurotoxic exposure to AMPH. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AXONS
KW - SUBSTANTIA nigra
KW - AMPHETAMINE abuse
KW - DOPAMINERGIC neurons
KW - DOPAMINERGIC mechanisms
KW - NEUROTOXICOLOGY
KW - Amphetamine
KW - Caudate putamen
KW - caudate putamen ( CPu )
KW - d-amphetamine ( AMPH )
KW - Dopamine
KW - Fluoro-JadeC ( FJ-C )
KW - Fluoro-Ruby
KW - Fluoro-Ruby ( FR )
KW - methamphetamine ( METH )
KW - Neurodegeneration
KW - substantia nigra compacta ( SNc )
N1 - Accession Number: 20186137; Bowyer, John F.; Email Address: jbowyer@nctr.fda.gov Schmued, Larry C. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, Jefferson, AR 72079-9502, USA; Source Info: Feb2006, Vol. 1075 Issue 1, p236; Subject Term: AXONS; Subject Term: SUBSTANTIA nigra; Subject Term: AMPHETAMINE abuse; Subject Term: DOPAMINERGIC neurons; Subject Term: DOPAMINERGIC mechanisms; Subject Term: NEUROTOXICOLOGY; Author-Supplied Keyword: Amphetamine; Author-Supplied Keyword: Caudate putamen; Author-Supplied Keyword: caudate putamen ( CPu ); Author-Supplied Keyword: d-amphetamine ( AMPH ); Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Fluoro-JadeC ( FJ-C ); Author-Supplied Keyword: Fluoro-Ruby; Author-Supplied Keyword: Fluoro-Ruby ( FR ); Author-Supplied Keyword: methamphetamine ( METH ); Author-Supplied Keyword: Neurodegeneration; Author-Supplied Keyword: substantia nigra compacta ( SNc ); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.brainres.2005.12.062
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olufunke Olagunju
AU - Paul D. Siegel
AU - Rotimi Olojo
AU - Reuben H. Simoyi
T1 - Oxyhalogen−Sulfur Chemistry: Kinetics and Mechanism of Oxidation of LoAcetylthiourea by Chlorite and Chlorine Dioxide1.
JO - Journal of Physical Chemistry A
JF - Journal of Physical Chemistry A
Y1 - 2006/02/23/
VL - 110
IS - 7
M3 - Article
SP - 2396
EP - 2410
SN - 10895639
AB - The oxidation reactions of N-acetylthiourea (ACTU) by chlorite and chlorine dioxide were studied in slightly acidic media. The ACTU−ClO2- reaction has a complex dependence on acid with acid catalysis in pH > 2 followed by acid retardation in higher acid conditions. In excess chlorite conditions the reaction is characterized by a very short induction period followed by a sudden and rapid formation of chlorine dioxide and sulfate. In some ratios of oxidant to reductant mixtures, oligo-oscillatory formation of chlorine dioxide is observed. The stoichiometry of the reaction is 2:1, with a complete desulfurization of the ACTU thiocarbamide to produce the corresponding urea product: 2ClO2- + CH3CONH(NH2)C=S + H2O → CH3CONH(NH2)C=O + SO42- + 2Cl- + 2H+ (A). The reaction of chlorine dioxide and ACTU is extremely rapid and autocatalytic. The stoichiometry of this reaction is 8ClO2(aq) + 5CH3CONH(NH2)C=S + 9H2O → 5CH3CONH(NH2)C=O + 5SO42- + 8Cl- + 18H+ (B). The ACTU−ClO2- reaction shows a much stronger HOCl autocatalysis than that which has been observed with other oxychlorine−thiocarbamide reactions. The reaction of chlorine dioxide with ACTU involves the initial formation of an adduct which hydrolyses to eliminate an unstable oxychlorine intermediate HClO2- which then combines with another ClO2 molecule to produce and accumulate ClO2-. The oxidation of ACTU involves the successive oxidation of the sulfur center through the sulfenic and sulfinic acids. Oxidation of the sulfinic acid by chlorine dioxide proceeds directly to sulfate bypassing the sulfonic acid. Sulfonic acids are inert to further oxidation and are only oxidized to sulfate via an initial hydrolysis reaction to yield bisulfite, which is then rapidly oxidized. Chlorine dioxide production after the induction period is due to the reaction of the intermediate HOCl species with ClO2-. Oligo-oscillatory behavior arises from the fact that reactions that form ClO2 are comparable in magnitude to those that consume ClO2, and hence the assertion of each set of reactions is based on availability of reagents that fuel them. A computer simulation study involving 30 elementary and composite reactions gave a good fit to the induction period observed in the formation of chlorine dioxide and in the autocatalytic consumption of ACTU in its oxidation by ClO2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physical Chemistry A is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HALOGENS
KW - CHLORITES (Chlorine compounds)
KW - CHLORINE dioxide
KW - PHYSICAL & theoretical chemistry
N1 - Accession Number: 20458244; Olufunke Olagunju 1 Paul D. Siegel 1 Rotimi Olojo 1 Reuben H. Simoyi 1; Affiliation: 1: Department of Chemistry, Portland State University, Portland, Oregon 97207-0751, and National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, West Virginia 26506; Source Info: Feb2006, Vol. 110 Issue 7, p2396; Subject Term: HALOGENS; Subject Term: CHLORITES (Chlorine compounds); Subject Term: CHLORINE dioxide; Subject Term: PHYSICAL & theoretical chemistry; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delmonte, Pierluigi
AU - Perry, Jesse
AU - Rader, Jeanne I.
T1 - Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: Extraction followed by basic or acid hydrolysis
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/02/24/
VL - 1107
IS - 1/2
M3 - Article
SP - 59
EP - 69
SN - 00219673
AB - Abstract: Isoflavones are phytochemicals found in many plants. Because of their structural similarity to β-estradiol, health benefits of isoflavones have been evaluated in age-related and hormone-dependent diseases. Dietary supplement preparations contain extracts from soy, Red Clover and kudzu. Soy products contain primarily genistein, daidzein, and glycitein, while Red Clover products contain primarily formononetin and biochanin A. Kudzu extracts contain puerarin and daidzein among other components. Previous methods of analysis focused on the determination of isoflavones from a single botanical source, while dietary supplements are often a blend of extracts from different plants. We developed a method for the analysis of isoflavones in dietary supplements regardless of their botanical composition, using HPLC-PDA because of its applicability to routine analysis. Isoflavones are found as free compounds, glucoside derivatives, 6″-O-malonyl-β-d-glucoside and 6″-O-acetyl-β-d-glucoside derivatives. In this study, the samples were extracted at room temperature with 50:50 (v/v) MeCN/water, and then analyzed before and after hydrolyzing the isoflavones by acid or basic digestion. 2′-Methoxy-flavone and 6-methoxy-flavone were used as internal standards and were added together to every sample. Daidzein, glycitein, genistein, puerarin, calycosin, pratensein, pseudobaptigenin, formononetin, biochanin A and prunetin were among the isoflavones determined. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Phytochemicals
KW - Dietary supplements
KW - Botanical chemistry
KW - Isoflavones
KW - Kudzu extract
KW - Red Clover extract
KW - Soy isoflavones
N1 - Accession Number: 19590926; Delmonte, Pierluigi; Email Address: pierluigi.delmonte@cfsan.fda.gov; Perry, Jesse 1; Rader, Jeanne I. 1; Affiliations: 1: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration (CFSAN-FDA), 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Feb2006, Vol. 1107 Issue 1/2, p59; Thesaurus Term: Phytochemicals; Thesaurus Term: Dietary supplements; Thesaurus Term: Botanical chemistry; Subject Term: Isoflavones; Author-Supplied Keyword: Kudzu extract; Author-Supplied Keyword: Red Clover extract; Author-Supplied Keyword: Soy isoflavones; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.chroma.2005.11.060
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19590926&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nunnery, Jennifer
AU - Angulo, Frederick J.
AU - Tollefson, Linda
T1 - Public health and policy
JO - Preventive Veterinary Medicine
JF - Preventive Veterinary Medicine
Y1 - 2006/02/24/
VL - 73
IS - 2/3
M3 - Article
SP - 191
EP - 195
SN - 01675877
AB - Abstract: Antimicrobial agent usage data are essential for focusing efforts to reduce misuse and overuse of antimicrobial agents in food producing animals because these practices may select for resistance in bacteria of animals. Transfer of resistant bacteria from animals to humans can lead to human infection caused by resistant pathogens. Resistant infections can lead to treatment failures, resulting in prolonged or more severe illness. Multiple World Health Organization (WHO) reports have concluded that both antimicrobial resistance and antimicrobial usage should be monitored on the national level. The system for collecting antimicrobial usage data should be clear and transparent to facilitate trend analysis and comparison within and among countries. Therapeutic, prophylactic and growth promotion use should be recorded, along with route of administration and animal species and/or production class treated. The usage data should be compared to resistance data, and the comparison should be made available in a timely manner. In the United States, surveillance of antimicrobial resistance in foodborne bacteria is performed by the National Antimicrobial Resistance Monitoring System (NARMS) for enteric bacteria, however, the United States still lacks a mechanism for collecting antimicrobial usage data. Combined with antimicrobial resistance information from NARMS, antimicrobial usage data will help to direct education efforts and policy decisions, minimizing the risk that people will develop antimicrobial resistant infections as a result of eating food of animal origin. Ultimately mitigation strategies guided by usage data will be more effective in maintaining antimicrobial drugs for appropriate veterinary use and in protecting human health. [Copyright &y& Elsevier]
AB - Copyright of Preventive Veterinary Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBIOTICS in veterinary medicine
KW - ANTI-infective agents in veterinary medicine
KW - PUBLIC health
KW - DRUG resistance in microorganisms
KW - Antimicrobial agents
KW - Monitoring
KW - Public health
KW - Surveillance
N1 - Accession Number: 19841489; Nunnery, Jennifer 1 Angulo, Frederick J. 1; Email Address: fja0@cdc.gov Tollefson, Linda 2; Affiliation: 1: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA 2: Center for Veterinary Medicine, United States Food and Drug Administration, 7519 Standish Place, Room 179, Rockville, MD 20855, USA; Source Info: Feb2006, Vol. 73 Issue 2/3, p191; Subject Term: ANTIBIOTICS in veterinary medicine; Subject Term: ANTI-infective agents in veterinary medicine; Subject Term: PUBLIC health; Subject Term: DRUG resistance in microorganisms; Author-Supplied Keyword: Antimicrobial agents; Author-Supplied Keyword: Monitoring; Author-Supplied Keyword: Public health; Author-Supplied Keyword: Surveillance; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.prevetmed.2005.09.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xie, Jing-Tian
AU - Shao, Zuo-Hui
AU - Vanden Hoek, Terry L.
AU - Chang, Wei-Tien
AU - Li, Jing
AU - Mehendale, Sangeeta
AU - Wang, Chong-Zhi
AU - Hsu, Chin-Wang
AU - Becker, Lance B.
AU - Yin, Jun-Jie
AU - Yuan, Chun-Su
T1 - Antioxidant effects of ginsenoside Re in cardiomyocytes
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2006/02/27/
VL - 532
IS - 3
M3 - Article
SP - 201
EP - 207
SN - 00142999
AB - Abstract: We have previously demonstrated that American ginseng berry extract exhibited significant protection against oxidant-mediated injury in cardiomyocytes. To extend this work, we sought to investigate the antioxidant effects of Re, a protopanaxatriols-type and single chemical integrant present in American ginseng berry extract, using the same chick cardiomyocyte model of oxidant injury as well as ESR spectroscopy in a cell-free chemical system. In cells exposed to 2 h of H2O2 (0.5 mM), pretreatment with Re (0.05, 0.1, or 0.5 mg/ml for 2 h) significantly attenuated 2′,7′-dichlorofluorescein (DCF) fluorescence by 51% (from 1345±67 to 658±46 a.u., P <0.001), and remarkably reduced cell death (from 51.5±3.0% to 11.8±1.5%, P <0.001, compared to the control). Similar results were also observed in cells exposed to antimycin A (100 μM), a mitochondrial electron transport chain site III inhibitor which increases endogenous oxidative stress. In the ESR study, however, Re failed to reduce the formation of the superoxide/DMPO adduct and DPPH radicals. These results suggest that ginsenoside Re functions as an antioxidant, protecting cardiomyocytes from oxidant injury induced by both exogenous and endogenous oxidants, and that its protective effects may be mostly attributed to scavenging H2O2 and hydroxyl radicals. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIOXIDANTS
KW - LIPOIC acid
KW - GINSENG
KW - HEART cells
KW - Antimycin A
KW - Antioxidant effect
KW - Cardiomyocyte
KW - ESR spectroscopy
KW - Ginsenoside Re
KW - H2O2
KW - Ischemia and reperfusion damage
N1 - Accession Number: 19915772; Xie, Jing-Tian 1,2 Shao, Zuo-Hui 1,3 Vanden Hoek, Terry L. 1,3 Chang, Wei-Tien 3 Li, Jing 4 Mehendale, Sangeeta 1,2 Wang, Chong-Zhi 1,2 Hsu, Chin-Wang 3 Becker, Lance B. 1,3 Yin, Jun-Jie 5 Yuan, Chun-Su 1,2,6; Email Address: cyuan@midway.uchicago.edu; Affiliation: 1: Tang Center for Herbal Medicine Research, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA 2: Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA 3: Section of Emergency Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA 4: Section of gastroenterology, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA 5: Center for Food Safety and Applied Nutrition, FDA, College Park, MD 20740, USA 6: Committee on Clinical Pharmacology and Pharmacogenomics, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA; Source Info: Feb2006, Vol. 532 Issue 3, p201; Subject Term: ANTIOXIDANTS; Subject Term: LIPOIC acid; Subject Term: GINSENG; Subject Term: HEART cells; Author-Supplied Keyword: Antimycin A; Author-Supplied Keyword: Antioxidant effect; Author-Supplied Keyword: Cardiomyocyte; Author-Supplied Keyword: ESR spectroscopy; Author-Supplied Keyword: Ginsenoside Re; Author-Supplied Keyword: H2O2; Author-Supplied Keyword: Ischemia and reperfusion damage; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ejphar.2006.01.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holdsworth, P.A.
AU - Vercruysse, J.
AU - Rehbein, S.
AU - Peter, R.J.
AU - Bruin, C. De
AU - Letonja, T.
AU - Green, P.
T1 - World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of ectoparasiticides against biting and nuisance flies on ruminants
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2006/02/28/
VL - 136
IS - 1
M3 - Article
SP - 3
EP - 13
SN - 03044017
AB - Abstract: These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of the efficacy of ectoparasiticides (excluding repellents) against the biting and nuisance dipteran flies of ruminants. Information is provided on the selection of animals, dose determination and dose confirmation studies, field studies, record keeping and result interpretation. These guidelines advocate the use of pen facilities for dose determination and dose confirmation studies. These guidelines also are intended to assist investigators on how to conduct specific studies, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the worldwide adoption of standard procedures. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITOLOGY
KW - ANTIPARASITIC agents
KW - RUMINANTS
KW - FLIES
KW - Biting flies
KW - Ectoparasiticides
KW - Guidelines
KW - Nuisance flies
KW - Persistent efficacy
KW - Ruminants
KW - Therapeutic efficacy
N1 - Accession Number: 19696579; Holdsworth, P.A. 1; Email Address: peter.holdsworth@avcare.org.au Vercruysse, J. 2 Rehbein, S. 3 Peter, R.J. 4 Bruin, C. De 5 Letonja, T. 6 Green, P. 7; Affiliation: 1: Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia 2: Department of Virology, Parasitology & Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium 3: Merial GmbH, Kathrinenhof Research Center, Walchenseestrasse 8-12, D-83101 Rohrdorf, Germany 4: Argos Veterinary Science (Pty) Ltd., P.O. Box 1726, Mount Edgecombe 4300, South Africa 5: P.O. Box 101, Kwelera, 5259 East London, South Africa 6: Center for Veterinary Medicine, 7500 Standish Place, MPN2, Rockville, MD 20855, USA 7: 9 Murna Street, Jindalee, 4074 Qld, Australia; Source Info: Feb2006, Vol. 136 Issue 1, p3; Subject Term: PARASITOLOGY; Subject Term: ANTIPARASITIC agents; Subject Term: RUMINANTS; Subject Term: FLIES; Author-Supplied Keyword: Biting flies; Author-Supplied Keyword: Ectoparasiticides; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Nuisance flies; Author-Supplied Keyword: Persistent efficacy; Author-Supplied Keyword: Ruminants; Author-Supplied Keyword: Therapeutic efficacy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.11.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19696579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holdsworth, P.A.
AU - Vercruysse, J.
AU - Rehbein, S.
AU - Peter, R.J.
AU - Bruin, C. De
AU - Letonja, T.
AU - Green, P.
T1 - World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of ectoparasiticides against myiasis causing parasites on ruminants
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2006/02/28/
VL - 136
IS - 1
M3 - Article
SP - 15
EP - 28
SN - 03044017
AB - Abstract: These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of efficacy of ectoparasiticides against the myiasis causing parasites of ruminants. These guidelines specifically focus on larvicidal efficacy against myiasis causing flies. Information is provided on the selection of animals, dose determination and dose confirmation studies, field studies, record keeping and result interpretation. These guidelines advocate the use of pen facilities for dose determination and dose confirmation studies for defining therapeutic and persistent efficacy. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the world-wide adoption of standard procedures. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITOLOGY
KW - ANTIPARASITIC agents
KW - MYIASIS
KW - PARASITES
KW - Ectoparasiticides
KW - Guidelines
KW - Larvae
KW - Myiasis
KW - Persistent efficacy
KW - Ruminants
KW - Therapeutic efficacy
N1 - Accession Number: 19696580; Holdsworth, P.A. 1; Email Address: peter.holdsworth@avcare.org.au Vercruysse, J. 2 Rehbein, S. 3 Peter, R.J. 4 Bruin, C. De 5 Letonja, T. 6 Green, P. 7; Affiliation: 1: Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia 2: Department of Virology, Parasitology & Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium 3: Merial GmbH, Kathrinenhof Research Center, Walchenseestrasse 8-12, D-83101 Rohrdorf, Germany 4: Argos Veterinary Science (Pty) Ltd., P.O. Box 1726, Mount Edgecombe 4300, South Africa 5: P.O. Box 101, Kwelera, 5259 East London, South Africa 6: Center for Veterinary Medicine, 7500 Standish Place, MPN2, Rockville, MD 20855, USA 7: 9 Murna Street, Jindalee, 4074 Qld, Australia; Source Info: Feb2006, Vol. 136 Issue 1, p15; Subject Term: PARASITOLOGY; Subject Term: ANTIPARASITIC agents; Subject Term: MYIASIS; Subject Term: PARASITES; Author-Supplied Keyword: Ectoparasiticides; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Larvae; Author-Supplied Keyword: Myiasis; Author-Supplied Keyword: Persistent efficacy; Author-Supplied Keyword: Ruminants; Author-Supplied Keyword: Therapeutic efficacy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.11.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19696580&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holdsworth, P.A.
AU - Kemp, D.
AU - Green, P.
AU - Peter, R.J.
AU - De Bruin, C.
AU - Jonsson, N.N.
AU - Letonja, T.
AU - Rehbein, S.
AU - Vercruysse, J.
T1 - World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of acaricides against ticks (Ixodidae) on ruminants
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2006/02/28/
VL - 136
IS - 1
M3 - Article
SP - 29
EP - 43
SN - 03044017
AB - Abstract: These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of the efficacy of acaricides (excluding vaccines and other bio-control agents) against single and multi-host ticks (Ixodidae) on ruminants. Information is provided on the selection of animals, dose determination, dose confirmation and field studies, record keeping and result interpretation. The use of pen facilities is advocated for dose determination and confirmation studies for defining therapeutic and persistent efficacy. A minimum of two studies per tick species for which claims are sought is recommended for each dose determination and dose confirmation investigation. If dose confirmation studies demonstrate greater than 95% efficacy the sponsor may proceed to field studies, where a minimum of two studies per geographical location is preferred to confirm the therapeutic and persistent efficacy under field conditions. If dose confirmation studies demonstrate less than 95% efficacy then longer-term field studies can be conducted over two tick seasons with a minimum of two studies per geographical location. These studies can incorporate other control methods such as tick vaccines, to demonstrate stable long-term tick management. Specific advice is also given on conducting studies with paralysis ticks. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new acaricides, and to facilitate the worldwide adoption of standard procedures. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITOLOGY
KW - ACARICIDES
KW - TICKS
KW - RUMINANTS
KW - Acaricides
KW - Guidelines
KW - Persistent efficacy
KW - Ruminants
KW - Strategic management program
KW - Therapeutic efficacy
KW - Ticks
N1 - Accession Number: 19696581; Holdsworth, P.A. 1; Email Address: peter.holdsworth@avcare.org.au Kemp, D. 2 Green, P. 3 Peter, R.J. 4 De Bruin, C. 5 Jonsson, N.N. 6 Letonja, T. 7 Rehbein, S. 8 Vercruysse, J. 9; Affiliation: 1: Avcare Limited, Locked Bag 916, Canberra 2601, ACT, Australia 2: CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, Brisbane 4067, Qld, Australia 3: 9 Murna Street, Jindalee 4074, Qld, Australia 4: Argos Veterinary Science (Pty) Ltd., P.O. Box 1726, Mount Edgecombe, 4300, South Africa 5: P.O. Box 101, Kwelera, 5259, East London, South Africa 6: School of Veterinary Science, University of Queensland 4072, Qld, Australia 7: Center for Veterinary Medicine, 7500 Standish Place, MPN2, Rockville, MD 20855, USA 8: Merial GmbH, Kathrinenhof Research Center, Walchenseestrasse 8-12, D-83101 Rohrdorf, Germany 9: Department of Virology, Parasitology & Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium; Source Info: Feb2006, Vol. 136 Issue 1, p29; Subject Term: PARASITOLOGY; Subject Term: ACARICIDES; Subject Term: TICKS; Subject Term: RUMINANTS; Author-Supplied Keyword: Acaricides; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Persistent efficacy; Author-Supplied Keyword: Ruminants; Author-Supplied Keyword: Strategic management program; Author-Supplied Keyword: Therapeutic efficacy; Author-Supplied Keyword: Ticks; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.11.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19696581&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holdsworth, P.A.
AU - Vercruysse, J.
AU - Rehbein, S.
AU - Peter, R.J.
AU - Letonja, T.
AU - Green, P.
T1 - World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of ectoparasiticides against biting lice, sucking lice and sheep keds on ruminants
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2006/02/28/
VL - 136
IS - 1
M3 - Article
SP - 45
EP - 54
SN - 03044017
AB - Abstract: These guidelines have been prepared to assist in the design, implementation and interpretation of studies for the assessment of the efficacy of ectoparasiticides against biting and sucking lice and sheep keds on ruminants. Information is provided on the selection of animals, dose determination, dose confirmation and field studies, record keeping and result interpretation. These guidelines advocate the use of pen facilities for dose determination and dose confirmation studies for defining therapeutic and persistent efficacy. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the world-wide adoption of standard procedures. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITOLOGY
KW - ANTIPARASITIC agents
KW - LICE
KW - RUMINANTS
KW - Biting lice
KW - Ectoparasiticides
KW - Guidelines
KW - Persistent efficacy
KW - Ruminants
KW - Sheep keds
KW - Sucking lice
KW - Therapeutic efficacy
N1 - Accession Number: 19696582; Holdsworth, P.A. 1; Email Address: peter.holdsworth@avcare.org.au Vercruysse, J. 2 Rehbein, S. 3 Peter, R.J. 4 Letonja, T. 5 Green, P. 6; Affiliation: 1: Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia 2: Department of Virology, Parasitology & Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium 3: Merial GmbH, Kathrinenhof Research Center, Walchenseestrasse 8-12, D-83101, Rohrdorf, Germany 4: Argos Veterinary Science (Pty) Ltd, P.O. Box 1726, Mount Edgecombe, 4300, South Africa 5: Center for Veterinary Medicine, 7500 Standish Place, MPN2, Rockville, MD 20855, USA 6: 9 Murna Street, Jindalee, 4074 Qld, Australia; Source Info: Feb2006, Vol. 136 Issue 1, p45; Subject Term: PARASITOLOGY; Subject Term: ANTIPARASITIC agents; Subject Term: LICE; Subject Term: RUMINANTS; Author-Supplied Keyword: Biting lice; Author-Supplied Keyword: Ectoparasiticides; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Persistent efficacy; Author-Supplied Keyword: Ruminants; Author-Supplied Keyword: Sheep keds; Author-Supplied Keyword: Sucking lice; Author-Supplied Keyword: Therapeutic efficacy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.11.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19696582&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vercruysse, J.
AU - Rehbein, S.
AU - Holdsworth, P.A.
AU - Letonja, T.
AU - Peter, R.J.
T1 - World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of acaricides against (mange and itch) mites on ruminants
JO - Veterinary Parasitology
JF - Veterinary Parasitology
Y1 - 2006/02/28/
VL - 136
IS - 1
M3 - Article
SP - 55
EP - 66
SN - 03044017
AB - Abstract: These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of the efficacy of acaricides against mange and itch mites on ruminants. Information is provided on the selection of animals, dose determination, dose confirmation and field studies, record keeping and result interpretation. These guidelines also are intended to assist the investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the worldwide adoption of standard procedures. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARASITOLOGY
KW - ACARICIDES
KW - MITES
KW - RUMINANTS
KW - Chorioptes
KW - Ectoparasiticides
KW - Guidelines
KW - Mange
KW - Persistent efficacy
KW - Psorobia
KW - Psoroptes
KW - Ruminants
KW - Sarcoptes
KW - Therapeutic efficacy
N1 - Accession Number: 19696583; Vercruysse, J. 1; Email Address: jozef.vercruysse@ugent.be Rehbein, S. 2 Holdsworth, P.A. 3 Letonja, T. 4 Peter, R.J. 5; Affiliation: 1: Department of Virology, Parasitology & Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium 2: Merial GmbH, Kathrinenhof-Research Center, Walchenseestrasse 8-12, D-83101, Rohrdorf, Germany 3: Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia 4: Center for Veterinary Medicine, 7500 Standish Place, MPN2, Rockville, MD 20855, USA 5: Argos Veterinary Science (Pty) Ltd., P.O. Box 1726, Mount Edgecombe 4300, South Africa; Source Info: Feb2006, Vol. 136 Issue 1, p55; Subject Term: PARASITOLOGY; Subject Term: ACARICIDES; Subject Term: MITES; Subject Term: RUMINANTS; Author-Supplied Keyword: Chorioptes; Author-Supplied Keyword: Ectoparasiticides; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Mange; Author-Supplied Keyword: Persistent efficacy; Author-Supplied Keyword: Psorobia; Author-Supplied Keyword: Psoroptes; Author-Supplied Keyword: Ruminants; Author-Supplied Keyword: Sarcoptes; Author-Supplied Keyword: Therapeutic efficacy; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vetpar.2005.11.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19696583&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tesfamariam, Belay
T1 - The Effects of HMG-CoA Reductase Inhibitors on Endothelial Function.
JO - American Journal of Cardiovascular Drugs
JF - American Journal of Cardiovascular Drugs
Y1 - 2006/03//
VL - 6
IS - 2
M3 - Article
SP - 115
EP - 120
SN - 11753277
AB - Vascular endothelial dysfunction is a complex phenomenon that is caused by an imbalance of vasodilator and vasoconstrictor factors that regulate the equilibrium-maintaining vascular tone. In the early phase of hypercholesterolemia, endothelial dysfunction precedes vascular wall lesions. One of the earliest recognizable benefits of treatment with HMG-CoA reductase inhibitors (statins) is the normalization of endothelium-dependent relaxation in hypercholesterolemia; this effect occurs before significant lowering of serum cholesterol levels. Recent insights into cellular mechanisms indicate that statins promote vasorelaxation by upregulating the expression of endothelial nitric oxide (NO) synthase, activating the phosphatidylinositide 3-kinase/Akt pathway, inhibiting superoxide anion generation and endothelin synthesis, and by anti-inflammatory effects. These effects appear to be linked to the inhibition of geranylgeranylation of small G proteins such as Rho and Rac GTPases. In this regard, statins preserve endothelial function through the improvement of NO bioavailability and the reduction of oxidative stress, thereby shifting the balance from vasoconstriction to vasodilation. This review highlights the various mechanisms underlying the vasculoprotective effects of statins, independent of their effects on cholesterol lowering. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Cardiovascular Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VASCULAR endothelium
KW - VASODILATORS
KW - VASOCONSTRICTORS
KW - HYPERCHOLESTEREMIA
KW - HYDROXYMETHYLGLUTARYL coenzyme A reductases
N1 - Accession Number: 20503309; Tesfamariam, Belay 1; Affiliation: 1: Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA; Source Info: 2006, Vol. 6 Issue 2, p115; Subject Term: VASCULAR endothelium; Subject Term: VASODILATORS; Subject Term: VASOCONSTRICTORS; Subject Term: HYPERCHOLESTEREMIA; Subject Term: HYDROXYMETHYLGLUTARYL coenzyme A reductases; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 2 Diagrams; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20503309&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106303849
T1 - The effects of HMG-CoA reductase inhibitors on endothelial function.
AU - Tesfamariam B
Y1 - 2006/03//
N1 - Accession Number: 106303849. Language: English. Entry Date: 20060714. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 100967755.
KW - Endothelium -- Drug Effects
KW - Statins -- Therapeutic Use
KW - Antioxidants
SP - 115
EP - 120
JO - American Journal of Cardiovascular Drugs
JF - American Journal of Cardiovascular Drugs
JA - AM J CARDIOVASC DRUGS
VL - 6
IS - 2
PB - Springer Science & Business Media B.V.
AB - Vascular endothelial dysfunction is a complex phenomenon that is caused by an imbalance of vasodilator and vasoconstrictor factors that regulate the equilibrium-maintaining vascular tone. In the early phase of hypercholesterolemia, endothelial dysfunction precedes vascular wall lesions. One of the earliest recognizable benefits of treatment with HMG-CoA reductase inhibitors (statins) is the normalization of endothelium-dependent relaxation in hypercholesterolemia; this effect occurs before significant lowering of serum cholesterol levels. Recent insights into cellular mechanisms indicate that statins promote vasorelaxation by upregulating the expression of endothelial nitric oxide (NO) synthase, activating the phosphatidylinositide 3-kinase/Akt pathway, inhibiting superoxide anion generation and endothelin synthesis, and by anti-inflammatory effects. These effects appear to be linked to the inhibition of geranylgeranylation of small G proteins such as Rho and Rac GTPases. In this regard, statins preserve endothelial function through the improvement of NO bioavailability and the reduction of oxidative stress, thereby shifting the balance from vasoconstriction to vasodilation. This review highlights the various mechanisms underlying the vasculoprotective effects of statins, independent of their effects on cholesterol lowering.
SN - 1175-3277
AD - Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.
U2 - PMID: 16555864.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106303849&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106468290
T1 - Renewed growth in hospital inpatient cost since 1998: variation across metropolitan areas and leading clinical conditions.
AU - Friedman BS
AU - Wong HS
AU - Steiner CA
Y1 - 2006/03//2006 Mar
N1 - Accession Number: 106468290. Language: English. Entry Date: 20060707. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 9613960.
KW - Hospitalization -- Economics
KW - Conceptual Framework
KW - Costs and Cost Analysis
KW - Descriptive Statistics
KW - Exploratory Research
KW - Inpatients
KW - Multiple Regression
KW - Record Review
KW - Funding Source
KW - Human
SP - 157
EP - 166
JO - American Journal of Managed Care
JF - American Journal of Managed Care
JA - AM J MANAGE CARE
VL - 12
IS - 3
CY - Plainsboro, New Jersey
PB - Intellisphere, LLC
AB - OBJECTIVE: To use disaggregated data about metropolitan statistical areas (MSAs) and clinical conditions to better describe the variation in cost increases and explore some of the hypothesized influences. STUDY DESIGN: The study uses the state inpatient databases from the Healthcare Cost and Utilization Project, containing all discharges from hospitals in 172 MSAs in 1998 and 2001. The discharge summary information was combined with standardized hospital accounting files, surveys of managed care plans, MSA demographics, and state data pertaining to caps on medical malpractice awards. METHODS: The analysis used descriptive comparisons and multivariate regressions of admission rate and cost per case in 9 leading disease categories across the MSAs. The increase in hospital input prices and changes in severity of illness were controlled. RESULTS and CONCLUSION: Metropolitan statistical areas with higher HMO market penetration continued to show lower admission rates, no less so in 2001 than in 1998. A cap on malpractice awards appeared to restrain admissions, but the net effect on hospital cost per adult eroded for those states with the most experience with award caps. Higher admission rates and increase in cost were found in several disease categories.
SN - 1088-0224
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; bfriedma@ahrq.gov
U2 - PMID: 16524348.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106468290&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106213781
T1 - Racial and ethnic differences in patient assessments of interactions with providers: disparities or measurement biases?
AU - Dayton E
AU - Zhan C
AU - Sangl J
AU - Darby C
AU - Moy E
Y1 - 2006/03//Mar/Apr2006
N1 - Accession Number: 106213781. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Instrumentation: Self Administered Questionnaire (SAQ) supplement to the Household component of the Medical Expenditure Panel Survey (MEPS). NLM UID: 9300756.
KW - Ethnic Groups
KW - Patient Attitudes
KW - Physician-Patient Relations
KW - Adolescence
KW - Aged
KW - Attitude Measures
KW - Blacks
KW - Coding
KW - Data Analysis Software
KW - Education, Continuing (Credit)
KW - Female
KW - Hispanics
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Sample Size
KW - Self Report
KW - Statistical Significance
KW - Surveys
KW - T-Tests
KW - Two-Tailed Test
KW - United States Agency for Healthcare Research and Quality
KW - Whites
KW - Human
SP - 109
EP - 114
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 21
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Patient assessment surveys have established a primary role in health care quality measurement as evidence has shown that information from patients can affect quality improvement for practitioners and lead to positive marketwide changes. This article presents findings from the recently released National Healthcare Disparities Report revealing that although most clinical quality and access indicators show superior health care for non-Hispanic whites compared with blacks and Hispanics, blacks and Hispanics assess their interactions with providers more positively than non-Hispanic whites do. The article explores possible explanations for these racial/ethnic differences, including potential pitfalls in survey design that draw biased responses by race/ethnicity. The article then suggests strategies for refining future research on racial/ethnic disparities based on patient assessment of health care.
SN - 1062-8606
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; edayton@ahrq.gov
U2 - PMID: 16533902.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106213781&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106184960
T1 - Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
AU - Wu KM
AU - Farrelly JG
Y1 - 2006/03//
N1 - Accession Number: 106184960. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9441347.
KW - Drugs, Investigational
KW - Thyroid Hormones -- Metabolism
KW - Animals
KW - Models, Biological
KW - Predictive Value of Tests
KW - Rats
KW - Risk Factors
KW - Thyroid Neoplasms -- Chemically Induced
KW - Thyroid Neoplasms -- Pathology
SP - 141
EP - 144
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
JA - AM J THER
VL - 13
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - New drugs that enhance metabolism or clearance of thyroid hormones in rats often trigger a sequence of toxicity events during chronic administration: reduction of thyroxine, elevation of thyroid-stimulating hormone (TSH) levels, and thyroid gland hyperfunction/growth. Hepatocellular hypertrophy and thyroid follicular hyperplasia are often observed with increased liver and thyroid organ weights. This unique toxicity profile seems to be species-specific because the thyroxine in rodents is metabolized rapidly, without thyroid hormone-binding globulin that serves as a reserve, as in humans. Thus, elevations of TSH were not reported in humans for drugs such as delavirdine, fluvastatin, nicardipine, phenobarbital, simvastatin, and spironolactone, all of which produce thyroid hyperplasia or tumors in rats. Further, the human thyroid is less sensitive to prolonged TSH stimulation than that of the rat (eg, endemic goiter patients with high TSH due to iodine deficiency do not develop thyroid cancer). In view of the species difference in sensitivity of the thyroid between rodents and humans, using the rat as an animal model to explore target organs of toxicity for a new drug that significantly enhances thyroid hormone metabolism/clearance and increases TSH levels would not be adequate. In this case, a compromised and dysfunctional hypothalamo-pituitary-thyroid system would confound the toxicity profile explored in preclinical toxicity testing and render the model an inadequate risk predictor for the new drug in humans. Under such conditions, IND and NDA sponsors of drugs exhibiting this activity profile should be encouraged to use alternative animal species for toxicity exploration to provide a more meaningful human risk prediction.
SN - 1075-2765
AD - HFD-530, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, USA. wuk@cder.fda.gov
U2 - PMID: 16645431.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106184960&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Locke, Joanne
AU - Rudd, Rima E.
AU - Doak, Leonard G.
AU - Doak, Cecilia C.
AU - Stableford, Sue
AU - Riffenburgh, Audrey
AU - Baker, Catherine
AU - Prokop, Laurel
AU - Farrell, Margaret M.
AU - Drass, Jan
T1 - Health Literacy: The Importance of Clear Communication for Better Health Report from Fifth Plain Language Association International (PLAIN) Conference.
JO - AMWA Journal: American Medical Writers Association Journal
JF - AMWA Journal: American Medical Writers Association Journal
Y1 - 2006/03//
VL - 21
IS - 1
M3 - Article
SP - 30
EP - 32
SN - 10756361
AB - This article highlights the Fifth Plain Language Association International (PLAIN) Conference that was held from November 4-5, 2005 in Washington, D.C. The event was hosted by PLAIN and was sponsored by the Plain Language Action and Information Network and the nonprofit Center for Plain Language. For the past years, the need to improve health literacy across the U.S. has been emerging as a significant issue, therefore, conference planners decided to make health literacy the event's featured topic. Lecturers in the health literacy sessions focused on the need to improve the understandability of health information and discussed the plain language strategies that make health information easier to understand.
KW - CONFERENCES & conventions
KW - ASSOCIATIONS, institutions, etc.
KW - LITERACY
KW - HEALTH education
KW - WASHINGTON (D.C.)
N1 - Accession Number: 20552832; Locke, Joanne 1 Rudd, Rima E. 2 Doak, Leonard G. 3 Doak, Cecilia C. 4 Stableford, Sue 5 Riffenburgh, Audrey 6,7 Baker, Catherine 8 Prokop, Laurel 9 Farrell, Margaret M. 10 Drass, Jan 11; Affiliation: 1: Plain Language Advisor, Office of Disease Prevention and Health Promotion, US Department of Health and Human Services 2: Senior Lecturer on Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 3: President, Patient Learning Associates 4: Director of Health Education, Patient Learning Associates 5: Founder and Director, AHEC Health Literacy Center, University of New England 6: President, Riffenburgh and Associates 7: Founding Member, Clear Language Group 8: Plain Language Communications, Bethesda, MD 9: Scientist and President, Techstyle Group LLC, Houston, TX 10: Public Affairs Specialist, National Cancer Institute, National Institutes of Health, Rockville, MD 11: Senior Technical Advisor, Centers for Medicare and Medicaid Service's Office of Research, Development, and Information; Source Info: 2006, Vol. 21 Issue 1, p30; Subject Term: CONFERENCES & conventions; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: LITERACY; Subject Term: HEALTH education; Subject Term: WASHINGTON (D.C.); NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105989068
T1 - Health literacy. The importance of clear communication for better health: report from Fifth Plain Language Association International (PLAIN) Conference.
AU - Locke J
AU - Rudd RE
AU - Doak LG
AU - Doak CC
AU - Stableford S
AU - Riffenburgh A
AU - Baker C
AU - Prokop L
AU - Farrell MM
AU - Drass CJ
Y1 - 2006/03//
N1 - Accession Number: 105989068. Language: English. Entry Date: 20080222. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8705793.
KW - Communication
KW - Congresses and Conferences
KW - Health Information
KW - Literacy -- Trends
KW - Health Literacy
KW - Consumer Health Information
KW - Drugs, Prescription -- Legislation and Jurisprudence -- United States
KW - Language
KW - United States
KW - United States Centers for Medicare and Medicaid Services
KW - Writing -- Methods
SP - 30
EP - 32
JO - AMWA Journal: American Medical Writers Association Journal
JF - AMWA Journal: American Medical Writers Association Journal
JA - AMWA J
VL - 21
IS - 1
CY - Rockville, Maryland
PB - American Medical Writers Association (AMWA)
SN - 1075-6361
AD - Plain Language Advisor in the Office of Disease Prevention and Health Promotion, US Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Maher, Paul D.
AU - Haffner, Marlene
T1 - Orphan Drug Designation and Pharmacogenomics: Options and Opportunities.
JO - BioDrugs
JF - BioDrugs
Y1 - 2006/03//
VL - 20
IS - 2
M3 - Article
SP - 71
PB - Springer Science & Business Media B.V.
SN - 11738804
AB - The rapid increase in characterization and understanding of the human genome has had a major impact on the development of therapies for rare diseases. The “inborn errors of metabolismâ€, which are generally rare diseases, are beginning to realize new therapies based on an understanding of disease processes at the genetic level. Likewise, an understanding of acquired genetic errors, as seen in cancer, is allowing for targeted approaches to therapy that are revolutionizing, in many cases, both standards of care and prognosis. Since its inception, the Office of Orphan Products Development has been privileged to witness many of the successes and also the failures of pharmacogenomics as it relates to rare diseases. This approach, from a regulatory standpoint, often calls into question even basic assumptions about disease classification. Phenotypically homogeneous diseases are more frequently becoming ‘subsetted’ on the basis of genomics; conversely, overlap of therapeutic mechanisms of action is increasingly seen across seemingly diverse diseases. With the recent completion of sequencing of the human genome, as well as the increasing ease of DNA sequencing, the promise and challenge of the pharmacogenetic approach to treatment will be expected to play an increasingly important role in development of new therapies for both rare and common diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of BioDrugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORPHAN drugs
KW - HUMAN genome
KW - NUCLEOTIDE sequence
KW - PHARMACOGENOMICS
N1 - Accession Number: 21017951; Maher, Paul D. 1; Email Address: paul.maher@fda.hhs.gov Haffner, Marlene 1; Affiliation: 1: Office of Orphan Products Development, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2006, Vol. 20 Issue 2, p71; Subject Term: ORPHAN drugs; Subject Term: HUMAN genome; Subject Term: NUCLEOTIDE sequence; Subject Term: PHARMACOGENOMICS; Number of Pages: 9p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pavletic, Steven Z.
AU - Martin, Paul
AU - Lee, Stephanie J.
AU - Mitchell, Sandra
AU - Jacobsohn, David
AU - Cowen, Edward W.
AU - Turner, Maria L.
AU - Akpek, Gorgun
AU - Gilman, Andrew
AU - McDonald, George
AU - Schubert, Mark
AU - Berger, Ann
AU - Bross, Peter
AU - Chien, Jason W.
AU - Couriel, Daniel
AU - Dunn, J.P.
AU - Fall-Dickson, Jane
AU - Farrell, Ann
AU - Flowers, Mary E.D.
AU - Greinix, Hildegard
T1 - Measuring Therapeutic Response in Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group Report
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2006/03//
VL - 12
IS - 3
M3 - Article
SP - 252
EP - 266
SN - 10838791
AB - Abstract: The lack of standardized criteria for quantitative measurement of therapeutic response in clinical trials poses a major obstacle for the development of new agents in chronic graft-versus-host disease (GVHD). This consensus document was developed to address several objectives for response criteria to be used in chronic GVHD-related clinical trials. The proposed measures should be practical for use both by transplantation and nontransplantation medical providers, adaptable for use in adults and in children, and focused on the most important chronic GVHD manifestations. The measures should also give preference to quantitative, rather than semiquantitative, measures; capture information regarding signs, symptoms, and function separately from each other; and use validated scales whenever possible to demonstrate improved patient outcomes and meet requirements for regulatory approval of novel agents. Based on these criteria, we propose a set of measures to be considered for use in clinical trials, and forms for data collection are provided (http://www.asbmt.org/GvHDForms). Measures should be made at 3-month intervals and whenever major changes are made in treatment. Provisional definitions of complete response, partial response, and progression are proposed for each organ and for overall outcomes. The proposed response criteria are based on current expert consensus opinion and are intended to improve consistency in the conduct and reporting of chronic GVHD trials, but their use remains to be demonstrated in practice. [Copyright &y& Elsevier]
AB - Copyright of Biology of Blood & Marrow Transplantation is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - GRAFT versus host disease
KW - CELLULAR therapy
KW - CELL transplantation
KW - REPORTING
KW - Allogeneic cell transplantation
KW - Chronic graft-versus-host disease
KW - Consensus
KW - Response criteria
N1 - Accession Number: 19849029; Pavletic, Steven Z. 1; Email Address: pavletis@mail.nih.gov Martin, Paul 2 Lee, Stephanie J. 3 Mitchell, Sandra 1 Jacobsohn, David 4 Cowen, Edward W. 1 Turner, Maria L. 1 Akpek, Gorgun 5 Gilman, Andrew 6 McDonald, George 2 Schubert, Mark 2 Berger, Ann 7 Bross, Peter 8 Chien, Jason W. 2 Couriel, Daniel 9 Dunn, J.P. 10 Fall-Dickson, Jane 11 Farrell, Ann 8 Flowers, Mary E.D. 2 Greinix, Hildegard 12; Affiliation: 1: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 2: Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 3: Dana-Farber Cancer Institute, Boston, Massachusetts 4: Children’s Memorial Hospital, Northwestern University School of Medicine, Chicago, Illinois 5: University of Maryland School of Medicine, Baltimore, Maryland 6: University of North Carolina School of Medicine, Chapel Hill, North Carolina 7: Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 8: US Food and Drug Administration, Rockville, Maryland 9: University of Texas M.D. Anderson Cancer Center, Houston, Texas 10: Johns Hopkins University School of Medicine, Baltimore, Maryland 11: National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland 12: Medical University of Vienna, Vienna, Austria; Source Info: Mar2006, Vol. 12 Issue 3, p252; Subject Term: CLINICAL trials; Subject Term: GRAFT versus host disease; Subject Term: CELLULAR therapy; Subject Term: CELL transplantation; Subject Term: REPORTING; Author-Supplied Keyword: Allogeneic cell transplantation; Author-Supplied Keyword: Chronic graft-versus-host disease; Author-Supplied Keyword: Consensus; Author-Supplied Keyword: Response criteria; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.bbmt.2006.01.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Temple, Robert
AU - Simon, Gregory
T1 - Letter -- FDA response to the STAR-D Study.
JO - Brown University Psychopharmacology Update
JF - Brown University Psychopharmacology Update
Y1 - 2006/03//
VL - 17
IS - 3
M3 - Article
SP - 5
EP - 5
PB - John Wiley & Sons, Inc.
SN - 10685308
AB - The article presents a response from the Center for Health Studies (CHS), to a letter from the U.S. Food and Drug Administration (FDA). Robert Temple, medical policy director of FDA, wrote about the study done by Gregory Simon and associates of CHS which talked about the FDA warnings that has been noted as inappropriate. As a response, Simon said that the study addresses different questions from the trial data the FDA examined.
KW - MENTAL health
KW - HEALTH
KW - RESEARCH
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - TEMPLE, Robert
KW - SIMON, Gregory
N1 - Accession Number: 20651868; Temple, Robert 1 Simon, Gregory 2; Affiliation: 1: Medical Policy Director, U.S. Food and Drug Administration 2: Center for Health Studies, Group Health Cooperative, Seattle, Washington; Source Info: Mar2006, Vol. 17 Issue 3, p5; Subject Term: MENTAL health; Subject Term: HEALTH; Subject Term: RESEARCH; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); People: TEMPLE, Robert; People: SIMON, Gregory; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106209652
T1 - Letter -- FDA response to the STAR-D Study...new study by Simon et al. (2006)
AU - Temple R
AU - Simon G
Y1 - 2006/03//
N1 - Accession Number: 106209652. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA.
KW - Antidepressive Agents -- Adverse Effects
KW - Drug Labeling
KW - Suicidal Ideation -- Chemically Induced
KW - Suicide -- Chemically Induced
KW - Suicide, Attempted
KW - United States Food and Drug Administration
KW - Suicide -- Risk Factors
KW - United States
SP - 5
EP - 5
JO - Brown University Psychopharmacology Update
JF - Brown University Psychopharmacology Update
JA - BROWN UNIV PSYCHOPHARMACOL UPDATE
VL - 17
IS - 3
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
SN - 1068-5308
AD - Medical Policy Director, U.S. Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gallagher, Sean
AU - Marras, William S.
AU - Litsky, Alan S.
AU - Burr, Deborah
T1 - An exploratory study of loading and morphometric factors associated with specific failure modes in fatigue testing of lumbar motion segments
JO - Clinical Biomechanics
JF - Clinical Biomechanics
Y1 - 2006/03//
VL - 21
IS - 3
M3 - Article
SP - 228
EP - 234
SN - 02680033
AB - Abstract: Background: There is currently little information regarding factors associated with specific modes of motion segment failure using a fatigue failure model. Methods: Thirty-six human lumbar motion segments were fatigue tested using spinal compressive and shear loads that simulated lifting a 9kg weight in three torso flexion angles (0°, 22.5°, and 45°). Twenty-five segments failed via fatigue prior to the 10,000 cycle maximum. These specimens were visually inspected and dissected so that the mode(s) of failure could be determined. Failure modes included endplate fractures (classified into nine varieties), vertebral body fractures, and/or zygapophysial joint disruption. Logistic regression analyses were performed to determine whether certain morphometric variables, amount of motion segment flexion, disk degeneration scores, and/or loading characteristics were associated with the occurrence of specific failure modes. Findings: Results indicated that stellate endplate fractures were associated with increased posterior shear forces (P <0.05) and less degenerated discs (P <0.01). Fractures running laterally across the endplate were associated with motion segments having larger volumes (P <0.01). Endplate depression was more common in smaller specimens (P <0.01), as well as those experiencing increased posterior shear force (P <0.05). Zygapophysial joint damage was more likely to occur in a neutral posture (P <0.01). Interpretation: These results suggest that prediction of failure modes (e.g., specific endplate fracture patterns) may be possible (at least for older specimens) given knowledge of the spinal loads along with certain characteristics of the lumbar spine. [Copyright &y& Elsevier]
AB - Copyright of Clinical Biomechanics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOGISTIC regression analysis
KW - LUMBAR vertebrae
KW - FATIGUE testing machines
KW - REGRESSION analysis
KW - Aging
KW - Disk degeneration
KW - Endplate fractures
KW - Lumbar spine
KW - Morphometry
KW - Motion segments
KW - Zygapophysial joints
N1 - Accession Number: 19598295; Gallagher, Sean 1; Email Address: sgallagher@cdc.gov Marras, William S. 2 Litsky, Alan S. 3 Burr, Deborah 4; Affiliation: 1: National Institute for Occupational Safety and Health, Mining Injury Prevention Branch, P.O. Box 18070, Pittsburgh, PA 152360070, USA 2: Biodynamics Laboratory, The Ohio State University, Columbus, OH 43210, USA 3: Orthopaedic BioMaterials Laboratory, The Ohio State University, Columbus, OH 43210, USA 4: Department of Health Services, Research Management, and Policy, University of Florida, Gainesville, FL 32611, USA; Source Info: Mar2006, Vol. 21 Issue 3, p228; Subject Term: LOGISTIC regression analysis; Subject Term: LUMBAR vertebrae; Subject Term: FATIGUE testing machines; Subject Term: REGRESSION analysis; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Disk degeneration; Author-Supplied Keyword: Endplate fractures; Author-Supplied Keyword: Lumbar spine; Author-Supplied Keyword: Morphometry; Author-Supplied Keyword: Motion segments; Author-Supplied Keyword: Zygapophysial joints; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.clinbiomech.2005.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106461459
T1 - An exploratory study of loading and morphometric factors associated with specific failure modes in fatigue testing of lumbar motion segments.
AU - Gallagher S
AU - Marras WS
AU - Litsky AS
AU - Burr D
Y1 - 2006/03//
N1 - Accession Number: 106461459. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8611877.
KW - Lumbar Vertebrae -- Physiology
KW - Lumbar Vertebrae -- Anatomy and Histology
KW - Stress, Mechanical
KW - Tensile Strength -- Evaluation
KW - Biomechanics
KW - Exploratory Research
KW - Cadaver
KW - Logistic Regression
KW - Descriptive Statistics
KW - Step-Wise Multiple Regression
KW - Human
SP - 228
EP - 234
JO - Clinical Biomechanics
JF - Clinical Biomechanics
JA - CLIN BIOMECH
VL - 21
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0268-0033
AD - National Institute for Occupational Safety and Health, Mining Injury Prevention Branch, PO Box 18070, Pittsburgh, PA 15236-0070; sgallagher@cdc.gov
U2 - PMID: 16297512.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - William Mwengee
AU - Thomas Butler
AU - Samuel Mgema
AU - George Mhina
AU - Yusuf Almasi
AU - Charles Bradley
AU - James B. Formanik
AU - C. George Rochester
T1 - Treatment of Plague with Gentamicin or Doxycycline in a Randomized Clinical Trial in Tanzania.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/03//3/1/2006
VL - 42
IS - 5
M3 - Article
SP - 614
EP - 621
SN - 10584838
AB - Background. Over the past 50 years, antibiotics of choice for treatment of plague, including streptomycin, chloramphenicol, and tetracycline, have mostly become outdated or unavailable. To test gentamicin in the treatment of naturally occurring plague and the implications of its use in the treatment of bioterrorist plague, a randomized, comparative, open-label, clinical trial comparing monotherapy with gentamicin or doxycycline was conducted in Tanzania. Methods. Sixty-five adults and children with symptoms of bubonic, septicemic, or pneumonic plague of ⩽3 days duration were enrolled in the study. Bubo aspirates and blood were cultured for Yersinia pestis. Acute-phase and convalescent-phase serum samples were tested for antibody against fraction 1 antigen of Y. pestis. Thirty-five patients were randomized to receive gentamicin (2.5 mg/kg intramuscularly every 12 h for 7 days), and 30 patients were randomized to receive doxycycline (100 mg [adults] and 2.2 mg/kg [children] orally every 12 h for 7 days). Serum creatinine concentrations were measured before and after treatment, and peak and trough concentrations of antibiotics were measured. Results. Three patients, 2 of whom were treated with gentamicin and 1 of whom was treated with doxycycline, died on the first or second day of treatment, and these deaths were attributed to advanced disease and complications including pneumonia, septicemia, hemorrhage, and renal failure at the start of therapy. All other patients experienced cure or an improved condition after receiving therapy, resulting in favorable response rates of 94% for gentamicin (95% CI, 81.1%–99.0%) and 97% for doxycycline (95% CI, 83.4%–99.8%). Y. pestis isolates obtained from 30 patients belonged to biotype antigua and were susceptible to gentamicin and doxycycline, which had MICs of 0.13 mg/L and 0.25–0.5 mg/L, respectively. Serum concentrations of antibiotics were within therapeutic ranges, and adverse events were infrequent. Patients treated with gentamicin demonstrated a modest increase in the mean serum creatinine concentration after treatment (P < .05, by paired t test). Conclusions. Both gentamicin and doxycycline were effective therapies for adult and pediatric plague, with high rates of favorable responses and low rates of adverse events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Antibacterial agents
KW - Gentamicin
KW - Streptomycin
KW - Chloramphenicol
KW - Tetracyclines
KW - Clinical trials
KW - Tanzania
N1 - Accession Number: 20239923; William Mwengee 1; Thomas Butler 2; Email Address: trigsby@jhmi.edu; Samuel Mgema 3; George Mhina 3; Yusuf Almasi 3; Charles Bradley 4; James B. Formanik 5; C. George Rochester 6; Affiliations: 1: Regional Medical Office, Tanga,; 2: Departments of Internal Medicine; 3: Lushoto District Hospital, Lushoto, Tanzania; 4: Departments of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas; 5: Ricerca Biosciences, Concord, Ohio; 6: Division of Biometrics III, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland; Issue Info: 3/1/2006, Vol. 42 Issue 5, p614; Thesaurus Term: Communicable diseases; Thesaurus Term: Antibacterial agents; Subject Term: Gentamicin; Subject Term: Streptomycin; Subject Term: Chloramphenicol; Subject Term: Tetracyclines; Subject Term: Clinical trials; Subject: Tanzania; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Shah, Rakhi B.
AU - Hullahalli, Prasanna R.
AU - Tawakkul, Mobin A.
AU - Faustino, Patrick J.
AU - Nguyenpho, Agnes
AU - Khan, MansoorA.
T1 - Development of a Validated Stability Indicating HPLC Method for Ranitidine Hydrochloride Syrup.
JO - Clinical Research & Regulatory Affairs
JF - Clinical Research & Regulatory Affairs
Y1 - 2006/03//
VL - 23
IS - 1
M3 - Editorial
SP - 35
EP - 51
PB - Taylor & Francis Ltd
SN - 10601333
AB - An isocratic reversed-phase high-performance liquid chromatographic method was developed and validated for the determination of ranitidine HCl in syrup. The samples were analyzed by high-performance liquid chromatography (HPLC). Chromatographic separation was achieved on a C 18 column using an acetonitrile–aqueous phosphate buffer (20:80, v/v) elution, buffer being 10 mM disodium hydrogen phosphate brought to pH 7.1 with sodium hydroxide (0.1 N). Validation steps involved measurement of selectivity, accuracy, and precision under conditions of repeatability, reproducibility, sensitivity, and robustness. The lower limit of quantification was 10µg/mL. The validated method has been demonstrated to be reliable for the determination of ranitidine HCl and its related compound C. Stress degradation studies included exposing ranitidine HCl powder and Zantac syrup to acid, alkali, oxidation, and accelerated temperature of 50 °C for 24 hrs and photolysis for 8 hrs. The peaks of degraded products were well resolved from the drug peak. The validation of this method indicated that it could be effectively used to monitor the stability of ranitidine HCl syrup. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Research & Regulatory Affairs is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - RANITIDINE
KW - ANTIHISTAMINES
KW - BUFFER solutions
KW - VALIDATION therapy
KW - DRUGS
KW - Assay
KW - HPLC
KW - Ranitidine hydrochloride
KW - Stability
KW - Stress degradation
KW - Validation
N1 - Accession Number: 20338812; Shah, Rakhi B. 1 Hullahalli, Prasanna R. 1 Tawakkul, Mobin A. 1 Faustino, Patrick J. 1 Nguyenpho, Agnes 1 Khan, MansoorA. 1; Email Address: khanm@cder.fda.gov; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Life Sciences Bldg 64, Silver Spring, MD, 20993-0002, USA; Source Info: 2006, Vol. 23 Issue 1, p35; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: RANITIDINE; Subject Term: ANTIHISTAMINES; Subject Term: BUFFER solutions; Subject Term: VALIDATION therapy; Subject Term: DRUGS; Author-Supplied Keyword: Assay; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Ranitidine hydrochloride; Author-Supplied Keyword: Stability; Author-Supplied Keyword: Stress degradation; Author-Supplied Keyword: Validation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 17p; Illustrations: 1 Diagram, 3 Charts, 12 Graphs; Document Type: Editorial
L3 - 10.1080/10601330500545556
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nurkiewicz, Timothy R.
AU - Porter, Dale W.
AU - Barger, Mark
AU - Millecchia, Lyndell
AU - Murali, K.
AU - Rao, K.
AU - Marvar, Paul J.
AU - Hubbs, Ann F.
AU - Castranova, Vincent
AU - Boegehold, Matthew A.
T1 - Systemic Microvascular Dysfunction and Inflammation after Pulmonary Particulate Matter Exposure.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/03//
VL - 114
IS - 3
M3 - Article
SP - 412
EP - 419
PB - Superintendent of Documents
SN - 00916765
AB - The epidemiologic association between pulmonary exposure to ambient particulate matter (PM) and cardiovascular dysfunction is well known, but the systemic mechanisms that drive this effect remain unclear. We have previously shown that acute pulmonary exposure to PM impairs or abolishes endothelium-dependent arteriolar dilation in the rat spinotrapezius muscle. The purpose of this study was to further characterize the effect of pulmonary PM exposure on systemic microvascular function and to identify local inflammatory events that may contribute to these effects. Rats were intratracheally instilled with residual oil fly ash (ROFA) or titanium dioxide at 0.1 or 0.25 mg/rat 24 hr before measurement of pulmonary and systemic microvascular responses. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar responses to intraluminal infusion of the Ca2+ ionophore A23187 or iontophoretic abluminal application of the adrenergic agonist phenylephrine (PHE). Leukocyte rolling and adhesion were quantified in venules paired with the studied arterioles. Histologic techniques were used to assess pulmonary inflammation, characterize the adherence of leukocytes to systemic venules, verify the presence of myeloperoxidase (MPO) in the systemic microvascular wall, and quantify systemic microvascular oxidative stress. In the lungs of rats exposed to ROFA or TiO2, changes in some bronchoalveolar lavage markers of inflammation were noted, but an indication of cellular damage was not found. In rats exposed to 0.1 mg ROFA, focal alveolitis was evident, particularly at sites of particle deposition. Exposure to either ROFA or TiO2 caused a dose-dependent impairment of endothelium-dependent arteriolar dilation. However, exposure to these particles did not affect microvascular constriction in response to PHE. ROFA and TiO2 exposure significantly increased leukocyte rolling and adhesion in paired venules, and these cells were positively identified as polymorphonuclear leukocytes (PMNLs). In ROFA- and TiO2-exposed rats, MPO was found in PMNLs adhering to the systemic microvascular wall. Evidence suggests that some of this MPO had been deposited in the microvascular wall. There was also evidence for oxidative stress in the microvascular wall. These results indicate that after PM exposure, the impairment of endothelium-dependent dilation in the systemic microcirculation coincides with PMNL adhesion, MPO deposition, and local oxidative stress. Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fly ash
KW - Cardiovascular toxicology
KW - Lung diseases
KW - Microscopy
KW - Leucocytes
KW - Oxidative stress
KW - Titanium dioxide
KW - Respiratory diseases
KW - Rats as laboratory animals
KW - arteriole
KW - endothelium
KW - microcirculation
KW - myeloperoxidase
KW - oxidative stress
KW - particulate matter
KW - polymorphonuclear leukocyte
KW - systemic
KW - venule
N1 - Accession Number: 20232208; Nurkiewicz, Timothy R. 1,2; Email Address: tnurkiewicz@hsc.wvu.edu; Porter, Dale W. 1,3; Barger, Mark 3; Millecchia, Lyndell 3; Murali, K. 3; Rao, K. 3; Marvar, Paul J. 1,2; Hubbs, Ann F. 3; Castranova, Vincent 1,3; Boegehold, Matthew A. 1,2; Affiliations: 1: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, USA; 2: Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA; 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Mar2006, Vol. 114 Issue 3, p412; Thesaurus Term: Fly ash; Subject Term: Cardiovascular toxicology; Subject Term: Lung diseases; Subject Term: Microscopy; Subject Term: Leucocytes; Subject Term: Oxidative stress; Subject Term: Titanium dioxide; Subject Term: Respiratory diseases; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: arteriole; Author-Supplied Keyword: endothelium; Author-Supplied Keyword: microcirculation; Author-Supplied Keyword: myeloperoxidase; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: particulate matter; Author-Supplied Keyword: polymorphonuclear leukocyte; Author-Supplied Keyword: systemic; Author-Supplied Keyword: venule; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1289/ehp.8413
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20232208&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ferguson, Christobel
AU - Deere, Dan
AU - Sinclair, Martha
AU - Chalmers, Rachel M.
AU - Elwin, Kristin
AU - Hadfield, Stephen
AU - Lihua Xiao
AU - Ryan, Una
AU - Gasser, Robin
AU - El-Osta, Youssef Abs
AU - Stevens, Melita
T1 - Meeting Report: Application of Genotyping Methods to Assess Risks from Cryptosporidiumin Watersheds.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/03//
VL - 114
IS - 3
M3 - Article
SP - 430
EP - 434
PB - Superintendent of Documents
SN - 00916765
AB - A workshop titled ‘Application of Genotyping Methods to Assess Pathogen Risks from Cryptosporidium in Drinking Water Catchments’ was held at the International Water Association biennial conference, Marrakech, Morocco, 23 September 2004. The workshop presented and discussed the findings of an interlaboratory trial that compared methods for genotyping Cryptosporidium oocysts isolated from feces. The primary goal of the trial and workshop was to assess the utility of current Cryptosporidium genotyping methods for determining the public health significance of oocysts isolated from feces in potable-water-supply watersheds. An expert panel of 16 watershed managers, public health practitioners, and molecular parasitologists was assembled for the workshop. A subordinate goal of the workshop was to educate watershed management and public health practitioners. An open invitation was extended to all conference delegates to attend the workshop, which drew approximately 50 interested delegates. In this report we summarize the peer consensus emerging from the workshop. Recommendations on the use of current methods by watershed managers and public health practitioners were proposed. Importantly, all the methods that were reported in the trial were mutually supporting and found to be valuable and worthy of further utility and development. Where there were choices as to which method to apply, the small-subunit ribosomal RNA gene was considered to be the optimum genetic locus to target. The single-strand conformational polymorphism method was considered potentially the most valuable for discriminating to the subtype level and where a large number of samples were to be analyzed. A research agenda for protozoan geneticists was proposed to improve the utility of methods into the future. Standardization of methods and nomenclature was promoted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drinking water
KW - Cryptosporidium
KW - Public health
KW - Watersheds
KW - Conferences & conventions
KW - Workshops (Adult education)
KW - Feces -- Examination
KW - Marrakech (Morocco)
KW - Morocco
KW - drinking water
KW - genotyping
KW - watersheds
N1 - Accession Number: 20232210; Ferguson, Christobel 1,2,3,4; Email Address: cferguson@ecowise.com.au; Deere, Dan 2; Sinclair, Martha 2,5; Chalmers, Rachel M. 6; Elwin, Kristin 6; Hadfield, Stephen 6; Lihua Xiao 7; Ryan, Una 8; Gasser, Robin 9; El-Osta, Youssef Abs 9; Stevens, Melita 10; Affiliations: 1: Ecowise Environmental, Canberra, Australia; 2: Cooperative Research Centre for Water Quality and Treatment, Adelaide, Australia; 3: University of New South Wales, Sydney, Australia; 4: Sydney Catchment Authority, Sydney, Australia; 5: Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; 6: National Public Health Service for England and Wales, Swansea, United Kingdom; 7: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 8: Murdoch University, Perth, Australia; 9: Melbourne University, Melbourne, Australia; 10: Melbourne Water, Melbourne, Australia; Issue Info: Mar2006, Vol. 114 Issue 3, p430; Thesaurus Term: Drinking water; Thesaurus Term: Cryptosporidium; Thesaurus Term: Public health; Thesaurus Term: Watersheds; Subject Term: Conferences & conventions; Subject Term: Workshops (Adult education); Subject Term: Feces -- Examination; Subject: Marrakech (Morocco); Subject: Morocco; Author-Supplied Keyword: drinking water; Author-Supplied Keyword: genotyping; Author-Supplied Keyword: watersheds; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
L3 - 10.1289/ehp.8240
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20232210&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lawson, Christina C.
AU - Grajewski, Barbara
AU - Daston, George P.
AU - Frazier, Linda M.
AU - Lynch, Dennis
AU - McDiarmid, Melissa
AU - Murono, Eisuke
AU - Perreault, Sally D.
AU - Robbins, Wendie A.
AU - Ryan, Megan A. K.
AU - Shelby, Michael
AU - Whelan, Elizabeth A.
T1 - Workgroup Report: Implementing a National Occupational Reproductive Research Agenda-Decade One and Beyond.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/03//
VL - 114
IS - 3
M3 - Article
SP - 435
EP - 441
PB - Superintendent of Documents
SN - 00916765
AB - The initial goal of occupational reproductive health research is to effectively study the many toxicants, physical agents, and biomechanical and psychosocial stressors that may constitute reproductive hazards in the workplace. Although the main objective of occupational reproductive researchers and clinicians is to prevent recognized adverse reproductive outcomes, research has expanded to include a broader spectrum of chronic health outcomes potentially affected by reproductive toxicants. To aid in achieving these goals, the National Institute for Occupational Safety and Health, along with its university, federal, industry, and labor colleagues, formed the National Occupational Research Agenda (NORA) in 1996. NORA resulted in 21 research teams, including the Reproductive Health Research Team (RHRT). In this report, we describe progress made in the last decade by the RHRT and by others in this field, including prioritizing reproductive toxicants for further study; facilitating collaboration among epidemiologists, biologists, and toxicologists; promoting quality exposure assessment in field studies and surveillance; and encouraging the design and conduct of priority occupational reproductive studies. We also describe new tools for screening reproductive toxicants and for analyzing mode of action. We recommend considering outcomes such as menopause and latent adverse effects for further study, as well as including exposures such as shift work and nanomaterials. We describe a broad domain of scholarship activities where a cohesive system of organized and aligned work activities integrates 10 years of team efforts and provides guidance for future research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Alternative toxicity testing
KW - Toxicologists
KW - Biologists
KW - Reproductive health
KW - Work environment
KW - Menopause
KW - United States
KW - communication
KW - environmental exposure
KW - occupational exposure
KW - reproduction
KW - research design
KW - risk factors
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 20232211; Lawson, Christina C. 1; Email Address: clawson@cdc.gov; Grajewski, Barbara 1; Daston, George P. 2; Frazier, Linda M. 3; Lynch, Dennis 1; McDiarmid, Melissa 4; Murono, Eisuke 5; Perreault, Sally D. 6; Robbins, Wendie A. 7; Ryan, Megan A. K. 8; Shelby, Michael 9; Whelan, Elizabeth A. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: Procter & Gamble, Cincinnati, Ohio, USA; 3: Department of Preventive Medicine and Public Health and Department of Obstetrics Gynecology, University of Kansas, Wichita, Kansas, USA; 4: Occupational Health Program, University of Maryland School of Medicine, Baltimore, Maryland, USA; 5: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 6: National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 7: Center for Occupational and Environmental Health, University of California at Los Angeles, Los Angeles, California, USA; 8: Department of Defense Center for Deployment Health Research, San Diego, California, USA; 9: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; Issue Info: Mar2006, Vol. 114 Issue 3, p435; Thesaurus Term: Industrial safety; Thesaurus Term: Alternative toxicity testing; Thesaurus Term: Toxicologists; Thesaurus Term: Biologists; Subject Term: Reproductive health; Subject Term: Work environment; Subject Term: Menopause; Subject: United States; Author-Supplied Keyword: communication; Author-Supplied Keyword: environmental exposure; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: reproduction; Author-Supplied Keyword: research design; Author-Supplied Keyword: risk factors ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 7p; Document Type: Article
L3 - 10.1289/ehp.8458
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20232211&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weschler, Charles J.
AU - Wells, J. R.
AU - Poppendieck, Dustin
AU - Hubbard, Heidi
AU - Pearce, Terri A.
T1 - Workgroup Report: Indoor Chemistry and Health.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/03//
VL - 114
IS - 3
M3 - Article
SP - 442
EP - 446
PB - Superintendent of Documents
SN - 00916765
AB - Chemicals present in indoor air can react with one another, either in the gas phase or on surfaces, altering the concentrations of both reactants and products. Such chemistry is often the major source of free radicals and other short-lived reactive species in indoor environments. To what extent do the products of indoor chemistry affect human health? To address this question, the National Institute for Occupational Safety and Health sponsored a workshop titled ‘Indoor Chemistry and Health’ on 12–15 July 2004 at the University of California-Santa Cruz. Approximately 70 experts from eight countries participated. Objectives included enhancing communications between researchers in indoor chemistry and health professionals, as well as defining a list of priority research needs related to the topic of the workshop. The ultimate challenges in this emerging field are defining exposures to the products of indoor chemistry and developing an understanding of the links between these exposures and various health outcomes. The workshop was a step toward meeting these challenges. This summary presents the issues discussed at the workshop and the priority research needs identified by the attendees. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Indoor air pollution
KW - Public health
KW - Workshops (Adult education)
KW - Free radicals (Chemistry)
KW - Chemicals
KW - Chemical research
KW - United States
KW - allergies
KW - asthma
KW - biomarkers
KW - environmental cancer
KW - free radicals
KW - hydroperoxides
KW - indoor pollutants
KW - inhalation exposure
KW - lung damage
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 20232212; Weschler, Charles J. 1,2; Email Address: weschlch@umdnj.edu; Wells, J. R. 3; Poppendieck, Dustin 4; Hubbard, Heidi 5; Pearce, Terri A. 3; Affiliations: 1: International Center for Indoor Environment and Energy, Technical University of Denmark, Lyngby, Denmark; 2: Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, New Jersey, USA; 3: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 4: Environmental Resources Engineering, Humboldt State University, Arcata, California, USA; 5: Department of Civil Engineering, University of Texas-Austin, Austin, Texas, USA; Issue Info: Mar2006, Vol. 114 Issue 3, p442; Thesaurus Term: Indoor air pollution; Thesaurus Term: Public health; Subject Term: Workshops (Adult education); Subject Term: Free radicals (Chemistry); Subject Term: Chemicals; Subject Term: Chemical research; Subject: United States; Author-Supplied Keyword: allergies; Author-Supplied Keyword: asthma; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: environmental cancer; Author-Supplied Keyword: free radicals; Author-Supplied Keyword: hydroperoxides; Author-Supplied Keyword: indoor pollutants; Author-Supplied Keyword: inhalation exposure; Author-Supplied Keyword: lung damage ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
L3 - 10.1289/ehp.8271
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20232212&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106141033
T1 - Workgroup report: implementing a national occupational reproductive research agenda--decade one and beyond.
AU - Lawson CC
AU - Grajewski B
AU - Daston GP
AU - Frazier LM
AU - Lynch D
AU - McDiarmid M
AU - Murono E
AU - Perreault SD
AU - Robbins WA
AU - Ryan MAK
AU - Shelby M
AU - Whelan EA
Y1 - 2006/03//
N1 - Accession Number: 106141033. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Hazardous Materials
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Health
KW - Reproduction -- Drug Effects
KW - Drug Toxicity
KW - National Institute for Occupational Safety and Health
KW - Reproductive Health
KW - Research
KW - United States
SP - 435
EP - 441
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 114
IS - 3
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - The initial goal of occupational reproductive health research is to effectively study the many toxicants, physical agents, and biomechanical and psychosocial stressors that may constitute reproductive hazards in the workplace. Although the main objective of occupational reproductive researchers and clinicians is to prevent recognized adverse reproductive outcomes, research has expanded to include a broader spectrum of chronic health outcomes potentially affected by reproductive toxicants. To aid in achieving these goals, the National Institute for Occupational Safety and Health, along with its university, federal, industry, and labor colleagues, formed the National Occupational Research Agenda (NORA) in 1996. NORA resulted in 21 research teams, including the Reproductive Health Research Team (RHRT). In this report, we describe progress made in the last decade by the RHRT and by others in this field, including prioritizing reproductive toxicants for further study; facilitating collaboration among epidemiologists, biologists, and toxicologists; promoting quality exposure assessment in field studies and surveillance; and encouraging the design and conduct of priority occupational reproductive studies. We also describe new tools for screening reproductive toxicants and for analyzing mode of action. We recommend considering outcomes such as menopause and latent adverse effects for further study, as well as including exposures such as shift work and nanomaterials. We describe a broad domain of scholarship activities where a cohesive system of organized and aligned work activities integrates 10 years of team efforts and provides guidance for future research.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. clawson@cdc.gov
U2 - PMID: 16507468.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106141033&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moore, C.
AU - Valappil, M.
AU - Corden, S.
AU - Westmoreland, D.
T1 - Enhanced clinical utility of the NucliSens EasyQ RSV A+B Assay for rapid detection of respiratory syncytial virus in clinical samples.
JO - European Journal of Clinical Microbiology & Infectious Diseases
JF - European Journal of Clinical Microbiology & Infectious Diseases
Y1 - 2006/03//
VL - 25
IS - 3
M3 - Article
SP - 167
EP - 174
SN - 09349723
AB - The aim of the present study was to compare traditional methods for the detection of respiratory syncytial virus with a newly developed commercial assay based on real-time nucleic acid sequence based amplification. Respiratory syncytial virus is a major cause of severe respiratory infection in infants and in certain groups of older children and adults. Treatment options are limited, but a rapid diagnosis improves patient management and infection control. The rapid diagnosis of respiratory syncytial virus currently relies on antigen detection assays. These tests are limited to use in certain good-quality types of samples, which are rarely obtained from adult patients. Molecular-based assays for the detection of respiratory syncytial virus are shown to be highly sensitive, specific, and more rapid than cell culture techniques. This retrospective study compared traditional laboratory techniques for the detection of respiratory syncytial virus in 508 respiratory samples collected during the winter months of 2003–2004 against the recently developed, commercially available NucliSens EasyQ Respiratory Syncytial Virus A+B assay (bioMérieux, Marcy l’Etoile, France), which is based on real-time nucleic acid sequence based amplification using molecular beacons and an internal control. Using traditional techniques, the prevalence of respiratory syncytial virus in the samples tested was found to be 21%. Using the real-time nucleic acid sequence-based amplification assay, an additional 41 samples from patients with a clinically diagnosed respiratory illness were found to be positive for respiratory syncytial virus. The NucliSens EasyQ assay was shown to be sensitive and specific for the detection of respiratory syncytial virus A+B in different types of respiratory samples. Moreover, the time required to complete the assay was <4 h, so results could be obtained on the same day as sample receipt in the laboratory. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Clinical Microbiology & Infectious Diseases is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - RESPIRATORY infections
KW - NUCLEIC acids
KW - ANTIGENS
KW - PNEUMONIA
KW - BRONCHOALVEOLAR lavage
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 20179713; Moore, C. 1; Email Address: catherine.moore@nphs.wales.nhs.uk Valappil, M. 1 Corden, S. 1 Westmoreland, D. 1; Affiliation: 1: Wales Specialist Virology Centre, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff, CF 14 4XW, UK; Source Info: Mar2006, Vol. 25 Issue 3, p167; Subject Term: RESPIRATORY syncytial virus; Subject Term: RESPIRATORY infections; Subject Term: NUCLEIC acids; Subject Term: ANTIGENS; Subject Term: PNEUMONIA; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/S10096-006-0112-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20179713&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guo, T.L.
AU - Chi, R.P.
AU - Zhang, X.L.
AU - Musgrove, D.L.
AU - Weis, C.
AU - Germolec, D.R.
AU - White, K.L.
T1 - Modulation of immune response following dietary genistein exposure in F 0 and F 1 generations of C57BL/6 mice: Evidence of thymic regulation
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/03//
VL - 44
IS - 3
M3 - Article
SP - 316
EP - 325
SN - 02786915
AB - Abstract: To further determine whether genistein (GEN) modulation of the immune responses was related to its endocrine-disrupting properties and time of exposure, pregnant C57BL/6 mice were exposed to GEN at 0–1250ppm in feed starting on day 14 of gestation. The C57BL/6 offspring were exposed to GEN in utero and lactationally, and through feed after weaning until postnatal day 42. In dams, exposure to GEN increased the terminal body weight (250 and 1250ppm), the number of splenic T cells and NK cells (250ppm), and the activity of NK cells (250ppm). In F 1 males, GEN increased the terminal body and spleen weights (25 and 250ppm), the number of CD4+CD8+ and CD4−CD8+ thymocytes (25ppm), and the number of splenic T cell subsets and NK cells (25 and 250ppm). Moreover, splenic NK cell activity and anti-CD3-mediated splenocyte proliferation were increased in all treatment groups. In F 1 females, the percentages of CD4−CD8+ and CD4−CD8− thymocytes (25 and 250ppm), and CD4+CD8− and CD4+CD8+ splenocytes (25 and 250ppm) were increased. In contrast, the percentage and number of CD4+CD8+ thymocytes were decreased (250ppm). Exposure to GEN decreased the percentages of splenic NK cells in all treatment groups, and decreased the activity of splenic NK cells at the 25ppm concentration. Additionally, evaluation of CD25+ and CD44+ expression by thymocytes indicated that the decrease in the percentage of CD44+CD25+ thymocytes was at least partially responsible for the decrease in the percentage of CD4−CD8− thymocytes in F 1 male mice. Overall, the results demonstrate that GEN can modulate the immune system in both adult and developing C57BL/6 mice in a dose-specific manner. The gender-specific effects of GEN on the immune responses in F 1 mice suggest that GEN may modulate the immune system by functioning as either an estrogen agonist or antagonist. The differential effects of GEN on thymocytes in F 1 male and female mice indicate that GEN immunomodulation might be related to its effect on thymus. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - T cells
KW - IMMUNE system
KW - MICE
KW - CD4 antigen
KW - Anti-CD3 mediated proliferation and phenotypic markers
KW - Genistein
KW - Natural killer cell activity
N1 - Accession Number: 19201609; Guo, T.L. 1; Email Address: tlguo@hsc.vcu.edu Chi, R.P. 1 Zhang, X.L. 1 Musgrove, D.L. 1 Weis, C. 2 Germolec, D.R. 3 White, K.L. 1; Affiliation: 1: Department of Pharmacology and Toxicology, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298-0613, USA 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA 3: Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA; Source Info: Mar2006, Vol. 44 Issue 3, p316; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: IMMUNE system; Subject Term: MICE; Subject Term: CD4 antigen; Author-Supplied Keyword: Anti-CD3 mediated proliferation and phenotypic markers; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Natural killer cell activity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.fct.2005.08.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19201609&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104743728
T1 - Provider-specific report cards: a tool for health sector accountability in developing countries.
AU - McNamara, Peggy
Y1 - 2006/03//
N1 - Accession Number: 104743728. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Health Services Administration; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 8610614.
KW - Health Care Delivery
KW - Developed Countries
KW - Information Systems
KW - Social Responsibility
KW - Quality of Health Care
SP - 101
EP - 109
JO - Health Policy & Planning
JF - Health Policy & Planning
JA - HEALTH POLICY PLANN
VL - 21
IS - 2
PB - Oxford University Press / USA
SN - 0268-1080
AD - Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. pmcnamar@ahrq.gov
U2 - PMID: 16431878.
DO - heapol/czj009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=104743728&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106284502
T1 - Enhancing quality improvement.
AU - Clancy CM
Y1 - 2006/03//
N1 - Accession Number: 106284502. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Dobrow M, Langer B, Angus H, Sullivan T. Quality councils as health system performance and accountability mechanisms: the Cancer Quality Council of Ontario experience. (HEALTHC PAP) 2006; 6 (3): 8-21. Commentary: Dobrow M, Langer B, Angus H, Sullivan T. The authors respond. (HEALTHC PAP) 2006; 6 (3): 58-61. Journal Subset: Canada; Editorial Board Reviewed; Health Services Administration; Peer Reviewed. NLM UID: 100961305.
KW - Leadership
KW - Management
KW - Quality Assurance -- Administration
KW - Quality Improvement
KW - Social Responsibility
KW - Clinical Indicators
KW - Health and Welfare Planning
KW - Organizational Efficiency
KW - Organizational Objectives
KW - Quality of Health Care
KW - United States
SP - 46
EP - 50
JO - Healthcare Papers
JF - Healthcare Papers
JA - HEALTHC PAP
VL - 6
IS - 3
CY - Toronto, Ontario
PB - Longwoods Publishing
AB - The healthcare systems of most developed nations face a common challenge: a substantial gap exists between the best possible care and the care routinely delivered. Numerous studies in the literature and reports from authoritative bodies, such as the Institute of Medicine (IOM) in the United States, have provided compelling and persuasive evidence that care is not consistently safe, timely, effective, equitable, efficient or patient-centred. A landmark study published in 2003 reported that Americans receive recommended care 54.9% of the time (McGlynn et al. 2003). The recent survey conducted by the Commonwealth Fund of sicker adults in six countries - Australia, Canada, Germany, New Zealand, the United Kingdom and the United States - underscores the pervasive challenges of providing high-quality care. The differences between the six countries pale in contrast to the common theme of significant opportunities for improvement in all nations (Schoen et al. 2005).
SN - 1488-917X
AD - Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland, USA.
U2 - PMID: 16651860.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106284502&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106205007
T1 - Informing quality health care.
AU - Clancy CM
Y1 - 2006/03//
N1 - Accession Number: 106205007. Language: English. Entry Date: 20070105. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 8215859.
KW - Quality of Health Care
KW - Electronic Health Records
KW - Information Technology
KW - Professional Practice, Evidence-Based
KW - Quality Improvement
KW - United States Agency for Healthcare Research and Quality
SP - 64
EP - 68
JO - hfm (Healthcare Financial Management)
JF - hfm (Healthcare Financial Management)
JA - HEALTHC FINANC MANAGE
VL - 60
IS - 3
CY - Westchester, Illinois
PB - Healthcare Financial Management Association
AB - Quality is the organizing principle for transforming our healthcare system. And the foundation for quality is information.
SN - 0735-0732
AD - Director, Agency for Healthcare Research and Quality
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106205007&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Day, Gregory A.
AU - Stefaniak, Aleksandr B.
AU - Weston, Ainsley
AU - Tinkle, Sally S.
T1 - Beryllium exposure: dermal and immunological considerations.
JO - International Archives of Occupational & Environmental Health
JF - International Archives of Occupational & Environmental Health
Y1 - 2006/03//
VL - 79
IS - 2
M3 - Article
SP - 161
EP - 164
PB - Springer Science & Business Media B.V.
SN - 03400131
AB - Objective: People exposed to beryllium compounds are at increased risk of developing beryllium sensitization and chronic beryllium disease (CBD). The purpose of this short communication is to present information regarding the potential importance of skin exposure to beryllium, an exposure and alternate immune response pathway to the respiratory tract, which has been largely overlooked in epidemiologic and exposure assessment studies. Methods: We reviewed the published literature, including epidemiologic, immunologic, genetic, and laboratory-based studies of in vivo and in vitro models, to assess the state of knowledge concerning skin exposure to beryllium. Results: Reduction in inhalation exposure to beryllium has not resulted in a concomitant reduction in the occurrence of beryllium sensitization or CBD, suggesting that continued prevalence may be due, in part, to unchecked skin exposure to beryllium-containing particles. Conclusions: Recent developments in our understanding of the multiple exposure pathways that may lead to beryllium sensitization and CBD suggest that a prudent approach to worker protection is to assess and minimize both skin and inhalation exposures to beryllium. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Archives of Occupational & Environmental Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Immunology
KW - Beryllium
KW - Alkaline earth metals
KW - Environmental health
KW - Environmental toxicology
KW - Beryllium compounds
KW - Chronic diseases
KW - Skin
KW - Exposure assessment methods
KW - Genetic factors
KW - Sensitization
KW - Skin exposure
N1 - Accession Number: 19095043; Day, Gregory A. 1; Email Address: gdd2@cdc.gov; Stefaniak, Aleksandr B. 1; Weston, Ainsley 2; Tinkle, Sally S. 3; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2703 Morgantown 26505-2888 USA; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown USA; 3: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park USA; Issue Info: Mar2006, Vol. 79 Issue 2, p161; Thesaurus Term: Immune response; Thesaurus Term: Immunology; Thesaurus Term: Beryllium; Thesaurus Term: Alkaline earth metals; Thesaurus Term: Environmental health; Thesaurus Term: Environmental toxicology; Subject Term: Beryllium compounds; Subject Term: Chronic diseases; Subject Term: Skin; Author-Supplied Keyword: Exposure assessment methods; Author-Supplied Keyword: Genetic factors; Author-Supplied Keyword: Sensitization; Author-Supplied Keyword: Skin exposure; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 4p; Document Type: Article
L3 - 10.1007/s00420-005-0024-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19095043&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vistnes, Jessica Primoff
AU - Morrisey, Michael A.
AU - Jensen, Gail A.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality
AD - Lister Hill Center for Health Policy, U AL
AD - Institute for Gerontology, Wayne State U
T1 - Employer Choices of Family Premium Sharing
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2006/03//
VL - 6
IS - 1
SP - 25
EP - 47
SN - 13896563
N1 - Accession Number: 0852404; Keywords: Insurance; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200607
N2 - In 1997, nearly two-thirds of married couples with children under age 18 were dual-earner couples. Such families may have a variety of insurance options available to them. If so, declining a high employee premium contribution may be a mechanism for one spouse to take money wages in lieu of coverage while the other spouse takes coverage rather than high wages. Employers may use these preferences and the size of premium contributions to encourage workers to obtain family coverage through their spouse. The purpose of this paper is to explore the effects of labor force composition, particularly the proportion of dual-earner couples in the labor market, on the marginal employee premium contribution (marginal EPC) for family coverage. We analyze data from the 1997-2001 Medical Expenditure Panel Survey--Insurance Component (MEPS-IC) List Sample of private establishments. We find strong evidence that the marginal EPC for family coverage is higher when there is a larger concentration of women in the workforce, but only in markets with a higher proportion of dual-earner households.
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Nonwage Labor Costs and Benefits; Retirement Plans; Private Pensions J32
L3 - http://link.springer.com/journal/volumesAndIssues/10754
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0852404&site=ehost-live&scope=site
UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Kumar, Virender
AU - Norton, Edward C.
AU - Encinosa, William E.
AD - Westat, Rockville, MD
AD - U NC
AD - Agency for Healthcare Research and Quality, Rockville, MD
T1 - OBRA 1987 and the Quality of Nursing Home Care
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2006/03//
VL - 6
IS - 1
SP - 49
EP - 81
SN - 13896563
N1 - Accession Number: 0852405; Keywords: Nursing Homes; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200607
N2 - Because minimum government standards for quality regulate only part of the market failure, they may have unintended effects. We present a general theory of how government regulation of quality of care may affect different market segments, and test the hypotheses for the nursing home market. OBRA 1987 was a sweeping government reform to improve the quality of nursing home care. We study how the effect of OBRA on the quality of nursing home care, measured by resident outcomes, varied with nursing home profitability. Using a semi-parametric method to control for the endogenous effects of regulation, we found that this landmark legislation had a negative effect on the quality of care in less profitable nursing homes, but improved the quality in more profitable nursing homes during the initial period after OBRA. But, this legislation had no statistically significant effect in the later period when the regulation was weakly enforced.
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Personal, Professional, and Business Services L84
L3 - http://link.springer.com/journal/volumesAndIssues/10754
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0852405&site=ehost-live&scope=site
UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Casanova, John A.
AU - Gross, Lois K.
AU - McMullen, Sarah E.
AU - Schenck, Frank J.
T1 - Use of Griess Reagent Containing Vanadium(III) for Post-Column Derivatization and Simultaneous Determination of Nitrite and Nitrate in Baby Food.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/03//Mar/Apr2006
VL - 89
IS - 2
M3 - Article
SP - 447
EP - 451
SN - 10603271
AB - The article examines the use ion chromatographic method with post-column derivatization and spectrophotometric detection for the determination of nitrate and nitrite in baby food. Vanadium (III) chloride and heat was used to reduce nitrate to nitrite online. A dye was produced due to the reaction of nitrite with Greiss reagent.
KW - CHROMATOGRAPHIC analysis
KW - NITRATES
KW - NITRITES
KW - BABY foods
KW - VANADIUM
N1 - Accession Number: 20603879; Casanova, John A. 1 Gross, Lois K. 1 McMullen, Sarah E. 1 Schenck, Frank J. 1; Email Address: fschenck@ora.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St NE, Atlanta, GA 30309; Source Info: Mar/Apr2006, Vol. 89 Issue 2, p447; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: NITRATES; Subject Term: NITRITES; Subject Term: BABY foods; Subject Term: VANADIUM; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 5p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20603879&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carson, Mary
AU - Reeves, Valerie
T1 - Veterinary Drug Residues.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/03//Mar/Apr2006
VL - 89
IS - 2
M3 - Article
SP - 566
EP - 566
SN - 10603271
AB - The article reports on the potential of leaving residues that may appear in human food with the agricultural use of drugs. The use of veterinary drugs are controlled by government regulatory authorities by approving or registering safe uses and monitoring food and imported products. Import monitoring programs have a major influence on international trade.
KW - VETERINARY drugs
KW - VETERINARY pharmacology
KW - FOOD contamination
KW - PESTICIDE residues in food
KW - FOOD -- Safety measures
N1 - Accession Number: 20603897; Carson, Mary 1 Reeves, Valerie 2; Affiliation: 1: U.S. Food and Drug Administration Laurel, MD 2: US. Food and Drug Administration Rockville, MD; Source Info: Mar/Apr2006, Vol. 89 Issue 2, p566; Subject Term: VETERINARY drugs; Subject Term: VETERINARY pharmacology; Subject Term: FOOD contamination; Subject Term: PESTICIDE residues in food; Subject Term: FOOD -- Safety measures; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 1p; Illustrations: 1 Black and White Photograph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20603897&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Quon, Dugane
AU - Carson, Mary C.
AU - Nochetto, Cristina
AU - Heller, David N.
AU - Butterworth, Fred
T1 - Peer Validation of a Method to Confirm Chloramphenicol in Honey by Liquid Chromatography-Tandem Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/03//Mar/Apr2006
VL - 89
IS - 2
M3 - Article
SP - 586
EP - 594
SN - 10603271
AB - The article reports on the peer validation of a method to confirm chloramphenicol in honey by liquid chromatography-tandem mass spectrometry. Using ethyl acetate, chloramphenicol is extracted from an aqueos dilution of honey. The method was able to meet confirmation criteria recommended by the U.S. Food and Drug Administration and 4-point identification criteria established by the European Union.
KW - CHLORAMPHENICOL
KW - HONEY
KW - ANTIBIOTICS assay
KW - LIQUID chromatography
KW - MASS spectrometry
N1 - Accession Number: 20603900; Quon, Dugane 1 Carson, Mary C. 2; Email Address: mary.carson@fda.gov Nochetto, Cristina 2 Heller, David N. 2 Butterworth, Fred 1; Affiliation: 1: Canadian Food Inspection Agency, Additives and Chemical Contaminants Unit, Calgary Laboratory, 3650 36th St NW, Calgary, Alberta, Canada T2L 2L1 2: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd, Laurel, MD 20708; Source Info: Mar/Apr2006, Vol. 89 Issue 2, p586; Subject Term: CHLORAMPHENICOL; Subject Term: HONEY; Subject Term: ANTIBIOTICS assay; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 9p; Illustrations: 3 Diagrams, 5 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20603900&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wood, Jennifer J.
AU - Malek, Mark A.
AU - Frassica, Frank J.
AU - Polder, Jacquelyn A.
AU - Mohan, Aparna K.
AU - Bloom, Eda T.
AU - Braun, M. Miles
AU - Coté, Timothy R.
T1 - AUTO CULTURED CHONDROCYTES: ADVERSE EVENTS REPORTED TO THE UNITED STATES FOOD AND DRUG ADMINISTRATION.
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
Y1 - 2006/03//
VL - 88
IS - 3
M3 - Article
SP - 503
EP - 507
SN - 00219355
AB - Background: Carticel is an autologous cultured chondrocyte product that has been approved by the United States Food and Drug Administration for the repair of symptomatic cartilaginous defects of the femoral condyle that are caused by acute or repetitive trauma in patients who have been previously managed with arthroscopy or other surgical procedures. The present report describes the adverse events following Carticel implantation as reported to the Food and Drug Administration from 1996 to 2003. Methods: We reviewed adverse event reports that had been submitted to the Food and Drug Administration's Med-Watch system for information on demographic characteristics, adverse events, and surgical revisions. Adverse events were categorized into sixteen non-mutually exclusive groups. Five categories were used to classify reoperations. Food and Drug Administration regulations require manufacturers to report adverse events; however, reporting by clinicians and others is voluntary. Therefore, adverse event reporting is likely to underestimate the number of event occurrences. Adverse events may be either causally or coincidentally related to the product. Results: A total of 497 adverse events among 294 patients receiving Carticel were reported. The median interval from Carticel implantation to the diagnosis of an adverse event was 240 days (range, one to 2105 days). The median age of the patients was thirty-eight years, and 63% of the patients were male. Of the 270 events for which the anatomic site was noted, 258 (96%) involved the femoral condyles. More than one adverse event was reported for 135 patients (46%). The most commonly reported events were graft failure (seventy-three patients; 25%), delamination (sixty-five patients; 22%), and tissue hypertrophy (fifty-two patients; 18%). In addition, eighteen surgical site infections were reported, including eleven joint and seven soft-tissue infections. Surgical revision subsequent to Carticel implantation was mentioned in the records for 273 patients (93%). The reasons for the 389 revision procedures included graft-related problems (187 procedures; 48.1%), periarticular soft-tissue problems (ninety-seven procedures; 24.9%), and intra-articular problems (sixty-three procedures; 16.2%). Eight patients had a total knee replacement. Based on the manufacturer's reported distribution of 7500 Carticel lots between 1995 and 2002, 285 patients (3.8%) had an adverse event that was reported to the Food and Drug Administration. Conclusions: The most common adverse events reported in association with the Carticel technique involved graft failure, delamination, and tissue hypertrophy. Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bone & Joint Surgery, American Volume is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARTILAGE cells
KW - JOINTS (Anatomy) -- Diseases
KW - JOINTS (Anatomy) -- Surgery
KW - ARTHROSCOPY
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 19827570; Wood, Jennifer J. Malek, Mark A. 1 Frassica, Frank J. 2 Polder, Jacquelyn A. 1 Mohan, Aparna K. Bloom, Eda T. 3 Braun, M. Miles 3; Email Address: braunm@cber.fda.gov Coté, Timothy R. 1; Affiliation: 1: Centers for Disease Control, MS-A34, MS-E08 and MS-G25, Atlanta 2: Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287 3: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852; Source Info: Mar2006, Vol. 88 Issue 3, p503; Subject Term: CARTILAGE cells; Subject Term: JOINTS (Anatomy) -- Diseases; Subject Term: JOINTS (Anatomy) -- Surgery; Subject Term: ARTHROSCOPY; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 5p; Document Type: Article
L3 - 10.2106/JBJS.E.00103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19827570&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105950889
T1 - Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration.
AU - Wood JJ
AU - Malek MA
AU - Frassica FJ
AU - Polder JA
AU - Mohan AK
AU - Bloom ET
AU - Braun MM
AU - Coté TR
AU - Wood, Jennifer J
AU - Malek, Mark A
AU - Frassica, Frank J
AU - Polder, Jacquelyn A
AU - Mohan, Aparna K
AU - Bloom, Eda T
AU - Braun, M Miles
AU - Coté, Timothy R
Y1 - 2006/03//
N1 - Accession Number: 105950889. Language: English. Entry Date: 20080201. Revision Date: 20160517. Publication Type: journal article. Journal Subset: Biomedical; Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0014030.
KW - Biological Factors -- Adverse Effects
KW - Cartilage Diseases -- Surgery
KW - Connective Tissue Cells -- Transplantation
KW - Product Evaluation
KW - United States Food and Drug Administration
KW - Adult
KW - Autografts -- Adverse Effects
KW - Cells
KW - Female
KW - Femur -- Surgery
KW - Male
KW - Middle Age
KW - Periosteum -- Transplantation
KW - Reoperation
KW - Surgical Wound Infection -- Etiology
KW - United States
SP - 503
EP - 507
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
JA - J BONE JOINT SURG (AM)
VL - 88
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background: Carticel is an autologous cultured chondrocyte product that has been approved by the United States Food and Drug Administration for the repair of symptomatic cartilaginous defects of the femoral condyle that are caused by acute or repetitive trauma in patients who have been previously managed with arthroscopy or other surgical procedures. The present report describes the adverse events following Carticel implantation as reported to the Food and Drug Administration from 1996 to 2003.Methods: We reviewed adverse event reports that had been submitted to the Food and Drug Administration's MedWatch system for information on demographic characteristics, adverse events, and surgical revisions. Adverse events were categorized into sixteen non-mutually exclusive groups. Five categories were used to classify reoperations. Food and Drug Administration regulations require manufacturers to report adverse events; however, reporting by clinicians and others is voluntary. Therefore, adverse event reporting is likely to underestimate the number of event occurrences. Adverse events may be either causally or coincidentally related to the product.Results: A total of 497 adverse events among 294 patients receiving Carticel were reported. The median interval from Carticel implantation to the diagnosis of an adverse event was 240 days (range, one to 2105 days). The median age of the patients was thirty-eight years, and 63% of the patients were male. Of the 270 events for which the anatomic site was noted, 258 (96%) involved the femoral condyles. More than one adverse event was reported for 135 patients (46%). The most commonly reported events were graft failure (seventy-three patients; 25%), delamination (sixty-five patients; 22%), and tissue hypertrophy (fifty-two patients; 18%). In addition, eighteen surgical site infections were reported, including eleven joint and seven soft-tissue infections. Surgical revision subsequent to Carticel implantation was mentioned in the records for 273 patients (93%). The reasons for the 389 revision procedures included graft-related problems (187 procedures; 48.1%), periarticular soft-tissue problems (ninety-seven procedures; 24.9%), and intra-articular problems (sixty-three procedures; 16.2%). Eight patients had a total knee replacement. Based on the manufacturer's reported distribution of 7500 Carticel lots between 1995 and 2002, 285 patients (3.8%) had an adverse event that was reported to the Food and Drug Administration.Conclusions: The most common adverse events reported in association with the Carticel technique involved graft failure, delamination, and tissue hypertrophy.
SN - 0021-9355
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
U2 - PMID: 16510814.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105950889&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - He Xu
AU - Xiaojie Zhang
AU - Mannon, Roslyn B.
AU - Kirk, Allan D.
T1 - Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2006/03//
VL - 116
IS - 3
M3 - Article
SP - 769
EP - 774
SN - 00219738
AB - CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs. Its blockade has been shown to prevent allograft rejection, presumably by interrupting interactions between T cells and APCs. It is known that activated human platelets express and shed CD154 and can induce APC activation and other immune processes in vitro. Here we show that platelet-derived CD154 is sufficient to initiate cardiac allograft rejection independent of any cellular source of this molecule. CD154-KO mice reject cardiac allografts after receiving CD154-expressing human platelets or recombinant CD154 (rCD154) trimers. Treatment with the human CD154-specific mAb 5c8 specifically prevents this induced rejection. Soluble trimers, but not platelets, induce rejection when infused temporally remote from the surgical procedure, suggesting that surgically induced platelet activation is required for CD154 release. Allograft rejection can thus be instigated by activated platelets through CD154. These data implicate platelets as a proximal component of acquired alloimmunity, providing insight into the mechanisms of allograft rejection and the physiological response to trauma in general. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - BLOOD platelet activation
KW - TRANSPLANTATION of organs, tissues, etc.
KW - LYMPHOCYTES
KW - FLOW cytometry
KW - LYMPH nodes
KW - CELL membranes
N1 - Accession Number: 19988831; He Xu 1 Xiaojie Zhang 1 Mannon, Roslyn B. 1 Kirk, Allan D. 1; Email Address: allanK@intra.niddk.nih.gov; Affiliation: 1: Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, United States Department of Health and Human Services, Bethesda, Maryland, USA; Source Info: Mar2006, Vol. 116 Issue 3, p769; Subject Term: T cells; Subject Term: BLOOD platelet activation; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: LYMPHOCYTES; Subject Term: FLOW cytometry; Subject Term: LYMPH nodes; Subject Term: CELL membranes; Number of Pages: 6p; Illustrations: 7 Color Photographs, 5 Graphs; Document Type: Article
L3 - 10.1172/JCI27155
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19988831&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106366858
T1 - FDA marketing claims, and the practitioner...Proceedings of the 2nd International Conference on Evidence-Based Dentistry
AU - Runner S
Y1 - 2006/03//
N1 - Accession Number: 106366858. Language: English. Entry Date: 20061201. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101083101.
KW - Equipment and Supplies -- Standards
KW - Marketing
KW - United States Food and Drug Administration -- Standards
SP - 19
EP - 23
JO - Journal of Evidence-Based Dental Practice
JF - Journal of Evidence-Based Dental Practice
JA - J EVID BASED DENT PRACT
VL - 6
IS - 1
CY - New York, New York
PB - Elsevier Science
AB - The Food and Drug Administration (FDA) is the federal agency that is tasked with regulating market entry for medical devices. The laws that govern this process are codified in the Federal Food Drug and Cosmetic Act (the Act) and the regulations are based on this law. The medical device amendments to the Act were instituted in 1976, instituting the methods for classification of medical devices and the format for the premarket review of devices.Information for practitioners on how medical devices come to market, what data are required, how specific claims are cleared, and how the practitioner can give input to the system are critical for the further development of safe and effective medical devices.
SN - 1532-3382
AD - Center for Devices and Radiological Health, Office of Device Evaluation, Food and Drug Administration, Rockville, MD
U2 - PMID: 17138391.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106366858&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chun, Jiyeon
AU - Martin, James A.
AU - Chen, Liwen
AU - Lee, Junsoo
AU - Ye, Lin
AU - Eitenmiller, Ronald R.
T1 - A differential assay of folic acid and total folate in foods containing enriched cereal-grain products to calculate μg dietary folate equivalents (μg DFE)
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2006/03//
VL - 19
IS - 2/3
M3 - Article
SP - 182
EP - 187
SN - 08891575
AB - Abstract: A method was developed to differentiate folic acid from total folate in enriched cereal products. By elimination of the protease and conjugase digestion steps from the trienzyme digestion used to measure total folate, folic acid can be directly quantified by the microbiological assay using Lactobacillus casei (ssp. rhamnosus) ATCC 7469. Determination of total folate by the trienzyme digestion together with assay of folic acid by the procedure reported here allows calculation of food folate and μg dietary folate equivalents (μg DFE). Recovery studies conducted at five concentration levels in a non-fortified wheat flour gave a mean recovery of 95.5 (RSD% 9.7) for folic acid and 98.5 (RSD% 5.0) for total folate. Recoveries from a variety of enriched cereal foods ranged from 88% to 99% for the folic acid extraction and 90% to 96% for the trienzyme digestion. Analysis of SRM 1846 Infant Formula gave means±s.d. of 123.5±6.9μg/100g of folic acid and 136.6±6.7μg/100g of total folate (reference concentration value=129±28μg/100g). Intermediate precision determined as intra-laboratory reproducibility(r) gave RSDr % values of 4.32 for the folic acid assay and 3.15 for the total folate assay. Microgram DFE values were determined for several enriched cereals by calculating food folate as the difference between total folate and folic acid and the formula μg DFE=μg food folate+(1.7×μg folic acid). The differential assay of folic acid and total folate is a simple and accurate procedure to determine μg DFE in enriched cereal-grains or foods containing enriched flour. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - VITAMIN B complex
KW - CEREAL products
KW - DIGESTION
KW - INFANT nutrition
KW - μg DFE
KW - Analysis
KW - Folic acid
KW - Food folate
KW - Total folate
N1 - Accession Number: 19167861; Chun, Jiyeon 1 Martin, James A. 2 Chen, Liwen 1 Lee, Junsoo 3 Ye, Lin 1 Eitenmiller, Ronald R. 1; Email Address: eiten@uga.edu; Affiliation: 1: Department of Food Science and Technology, University of Georgia, Athens, GA 30602, USA 2: Atlanta Center for Nutrient Analysis, Southeastern Regional Laboratory, United States Food and Drug Administration, Atlanta, GA 30309, USA 3: Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungbuk, 361-763, Korea; Source Info: Mar2006, Vol. 19 Issue 2/3, p182; Subject Term: FOLIC acid; Subject Term: VITAMIN B complex; Subject Term: CEREAL products; Subject Term: DIGESTION; Subject Term: INFANT nutrition; Author-Supplied Keyword: μg DFE; Author-Supplied Keyword: Analysis; Author-Supplied Keyword: Folic acid; Author-Supplied Keyword: Food folate; Author-Supplied Keyword: Total folate; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jfca.2005.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DeFrancesco, James V.
AU - Witkowski, Mark R.
AU - Ciolino, Laura A.
T1 - GHB Free Acid: I. Solution Formation Studies and Spectroscopic Characterization by 1HNMR and FT-IR.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2006/03//
VL - 51
IS - 2
M3 - Article
SP - 321
EP - 329
SN - 00221198
AB - In forensic evidence, γ-hydroxybutyric acid (GHB) has frequently been encountered in one of its salt forms (γ-hydroxybutyrate), but has also been encountered in its free acid form (GHB). Owing to the physical properties, encounters of the free acid have been largely restricted to forensic exhibits comprising aqueous solutions, such as acidic beverages that have been “spiked” or formulated with GHB salts or γ-butyrolactone (GBL). The analysis of GHB free acid presents particular difficulties including the potential for altering the original proportions of GHB free acid, GHB carboxylate, and GBL in the course of analysis, and discrimination between GHB free acid and carboxylate forms. In this work, the formation of GHB free acid in aqueous solutions (water and/or D2O) was studied as a function of solution pH. Proton nuclear magnetic resonance (1HNMR) and Fourier-transform infrared spectrometry (FT-IR) measurements were obtained on freshly prepared mixtures of NaGHB and HCl stock solutions representing a series of points along the GHB titration curve. Both 1HNMR and FT-IR were shown to track the changing proportions of GHB free acid and carboxylate forms as a function of pH, while simultaneously monitoring for the formation of the lactone (GBL). The results were consistent with acid–base conversion behavior for a carboxylic acid. 1HNMR was shown to provide an ideal means for analysis of aqueous-based GHB/GBL forensic exhibits based on simple dilution of the neat liquid exhibit, without altering the original proportions of GHB free acid, carboxylate, and GBL in the samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Forensic Sciences (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAMMA-hydroxybutyrate
KW - FOURIER transforms
KW - ACIDS
KW - NUCLEAR magnetic resonance
KW - SPECTRUM analysis
KW - FORENSIC sciences
KW - γ-hydroxybutyrate
KW - γ-hydroxybutyric acid
KW - γ-hydroxybutyrate
KW - γ-hydroxybutyric acid
KW - 1HNMR
KW - forensic science
KW - FT-IR
KW - GBL
KW - GHB
KW - GHB free acid
KW - interconversion
KW - NMR
KW - sodium oxybate
KW - solution spectroscopic analysis
N1 - Accession Number: 20562562; DeFrancesco, James V. 1 Witkowski, Mark R. 2; Email Address: mwitkows@ora.fda.gov Ciolino, Laura A. 2; Affiliation: 1: US Drug Enforcement Administration, North Central Regional Laboratory, Chicago, IL, 60606 2: US Food and Drug Administration Forensic Chemistry, Cincinnati, OH 45237; Source Info: Mar2006, Vol. 51 Issue 2, p321; Subject Term: GAMMA-hydroxybutyrate; Subject Term: FOURIER transforms; Subject Term: ACIDS; Subject Term: NUCLEAR magnetic resonance; Subject Term: SPECTRUM analysis; Subject Term: FORENSIC sciences; Author-Supplied Keyword: γ-hydroxybutyrate; Author-Supplied Keyword: γ-hydroxybutyric acid; Author-Supplied Keyword: γ-hydroxybutyrate; Author-Supplied Keyword: γ-hydroxybutyric acid; Author-Supplied Keyword: 1HNMR; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: FT-IR; Author-Supplied Keyword: GBL; Author-Supplied Keyword: GHB; Author-Supplied Keyword: GHB free acid; Author-Supplied Keyword: interconversion; Author-Supplied Keyword: NMR; Author-Supplied Keyword: sodium oxybate; Author-Supplied Keyword: solution spectroscopic analysis; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 9p; Illustrations: 1 Diagram, 9 Graphs; Document Type: Article
L3 - 10.1111/j.1556-4029.2006.00073.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Witkowski, Mark R.
AU - Ciolino, Laura A.
AU - DeFrancesco, James V.
T1 - GHB Free Acid: II. Isolation and Spectroscopic Characterization for Forensic Analysis.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2006/03//
VL - 51
IS - 2
M3 - Article
SP - 330
EP - 339
SN - 00221198
AB - A reference standard for γ-hydroxybutyric acid (GHB) free acid is not commercially available, making its analysis in forensic exhibits more difficult. GHB free acid is typically encountered in aqueous solution and in the presence of the lactone, γ-butyrolactone (GBL), presenting difficulty in Fourier transform infrared (FT-IR) analysis. The strong infrared (IR) absorptivity of the GBL carbonyl band, the shifting of the GBL carbonyl band in aqueous solutions, and the position of the O–H bend for water can mask the main carbonyl band for GHB free acid. Model solutions of β-hydroxybutyric acid (BHB) and GBL were studied in order to further understand the masking of the GHB free acid carbonyl band in FT-IR analysis. The use of second derivative FT-IR spectroscopy was shown to provide resolution of the free acid carbonyl band, and a presumptive test for GHB free acid was developed and applied. An extension of this work included preparing, for use as a standard reference material, small amounts (≤10 mg) of GHB free acid. Preparation was based on the instantaneous reaction of GHB's sodium salt with a stoichiometric amount of hydrochloric acid in aqueous solution, and subsequent isolation of the free acid in neat liquid form. Both FT-IR and proton nuclear magnetic resonance spectra of the neat reference material were obtained and used to verify its identity. The isolation of GHB free acid from actual forensic exhibits is also presented, with identity confirmation using FT-IR. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Forensic Sciences (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAMMA-hydroxybutyrate
KW - FOURIER transforms
KW - ACIDS
KW - NUCLEAR magnetic resonance
KW - SPECTRUM analysis
KW - FORENSIC sciences
KW - γ-hydroxybutyrate
KW - γ-hydroxybutyric acid
KW - 1HNMR
KW - forensic science
KW - FTIR
KW - g-hydroxybutyric acid
KW - gamma-hydroxybutyrate
KW - GBL
KW - GHB
KW - GHB free acid
KW - interconversion
KW - isolation
KW - NMR
KW - sodium oxybate
KW - spectroscopic analysis
N1 - Accession Number: 20562561; Witkowski, Mark R. 1; Email Address: mwitkows@ora.fda.gov Ciolino, Laura A. 1 DeFrancesco, James V. 2; Affiliation: 1: US Food and Drug Administration Forensic Chemistry, Cincinnati, OH 45237 2: US Drug Enforcement Administration, North Central Regional Laboratory, Chicago, IL 60606; Source Info: Mar2006, Vol. 51 Issue 2, p330; Subject Term: GAMMA-hydroxybutyrate; Subject Term: FOURIER transforms; Subject Term: ACIDS; Subject Term: NUCLEAR magnetic resonance; Subject Term: SPECTRUM analysis; Subject Term: FORENSIC sciences; Author-Supplied Keyword: γ-hydroxybutyrate; Author-Supplied Keyword: γ-hydroxybutyric acid; Author-Supplied Keyword: 1HNMR; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: FTIR; Author-Supplied Keyword: g-hydroxybutyric acid; Author-Supplied Keyword: gamma-hydroxybutyrate; Author-Supplied Keyword: GBL; Author-Supplied Keyword: GHB; Author-Supplied Keyword: GHB free acid; Author-Supplied Keyword: interconversion; Author-Supplied Keyword: isolation; Author-Supplied Keyword: NMR; Author-Supplied Keyword: sodium oxybate; Author-Supplied Keyword: spectroscopic analysis; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 10p; Illustrations: 3 Charts, 12 Graphs; Document Type: Article
L3 - 10.1111/j.1556-4029.2006.00074.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20562561&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106113595
T1 - Factors associated with high-quality/low-cost hospital performance.
AU - Jiang HJ
AU - Friedman B
AU - Begun JW
Y1 - 2006///Spring2006
N1 - Accession Number: 106113595. Language: English. Entry Date: 20070706. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 9503024.
KW - Health Facility Administration
KW - Health Facility Costs
KW - Hospitals
KW - Evaluation Research
KW - Logistic Regression
KW - Sample Size
KW - Software
KW - United States Agency for Healthcare Research and Quality
KW - Human
SP - 39
EP - 52
JO - Journal of Health Care Finance
JF - Journal of Health Care Finance
JA - J HEALTH CARE FINANC
VL - 32
IS - 3
CY - New York, New York
PB - Aspen Publishers Inc.
AB - This study explores organizational and market characteristics associated with superior hospital performance in both quality and cost of care, using the Healthcare Cost and Utilization Project State Inpatient Databases for ten states in 1997 and 2001. After controlling for a variety of patient factors, we found that for-profit ownership, hospital competition, and the number of HMOs were positively associated with the likelihood of attaining high-quality/low-cost performance. Furthermore, we examined interactions between organizational and market characteristics and identified a number of significant interactions. For example, the positive likelihood associated with for-profit hospitals diminished in markets with high HMO penetration. Copyright © 2006 by Aspen Publishers, Inc.
SN - 1078-6767
AD - Social Scientist, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality
U2 - PMID: 18975731.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106113595&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106371101
T1 - Book review...Lesbian women and sexual health: the social construction of risk and susceptibility
AU - Razzano LA
Y1 - 2006/03//
N1 - Accession Number: 106371101. Language: English. Entry Date: 20061208. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 100968761.
KW - Female
KW - Lesbians
KW - Sexual Health
SP - 85
EP - 87
JO - Journal of HIV/AIDS & Social Services
JF - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS SOC SERV
VL - 5
IS - 1
PB - Taylor & Francis Ltd
SN - 1538-1501
AD - Associate Professor of Psychiatry, Center on Mental Health Services Research & Policy, University of Illinois at Chicago, Chicago, IL
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Raghunathan, Pratima L.
AU - Jones, Joshua D.
AU - Tiendrebéogo, Sylvestre R. M.
AU - Sanou, Idrissa
AU - Sangaré, Lassana
AU - Kouanda, Seni
AU - Dabal, Moumouni
AU - Lingani, Clement
AU - Elie, Cheryl M.
AU - Johnson, Scott
AU - Ari, Mary
AU - Martinez, Joseph
AU - Chatt, Julie
AU - Sidibe, Kassim
AU - Schmink, Susanna
AU - Mayer, Leonard W.
AU - Kondé, M. Kader
AU - Djingarey, Mamoudou H.
AU - Popovic, Tanja
AU - Plikaytis, Brian D.
T1 - Predictors of Immunity after a Major Serogroup W-135 Meningococcal Disease Epidemic, Burkina Faso, 2002.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/03//3/1/2006
VL - 193
IS - 5
M3 - Article
SP - 607
EP - 616
SN - 00221899
AB - Background. The African meningitis belt undergoes recurrent epidemics caused by Neisseria meningitidis sero-group A. During 2002, Burkina Faso documented the first large serogroup W-135 (NmW-135) meningococcal disease epidemic. To understand the emergence of NmW-135, we investigated meningococcal carriage and immunity. Methods. Immediately after Burkina Faso's epidemic, we conducted a cross-sectional survey of meningococcal carriage and seroprevalence in an epidemic and a nonepidemic district. We identified predictors of elevated NmW-135 serum bactericidal activity (SBA), a functional correlate of protection, using multivariate logistic regression. Results. The NmW-135 carriage rate was 25.2% in the epidemic district and 3.4% in the nonepidemic district (P<.0001). Compared with residents of the nonepidemic district, those of the epidemic district had higher geometric mean titers of NmW-135 SBA (P <.0001). NmW-135 SBA titers ⩾ 1:8, an estimated protective threshold, were observed in 60.4% and 34.0% of residents of the epidemic and nonepidemic district, respectively (P = .0002). In a multivariate model, current NmW-135 carriage, age, and residence in the epidemic district were independent predictors of having an NmW-135 SBA titer ⩾1:8. Conclusions. Extensive NmW-135 carriage and transmission in the epidemic area caused residents to acquire natural immunity. Serial carriage and seroprevalence surveys could establish the duration of immunity in the population. The persistent circulation of NmW-135 underscores the potential for periodic NmW-135 epidemics in Africa. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNITY
KW - EPIDEMICS
KW - NEISSERIA meningitidis
KW - SERUM
KW - COMMUNICABLE diseases
KW - BURKINA Faso
N1 - Accession Number: 19805481; Raghunathan, Pratima L. 1; Email Address: pgr4@cdc.gov Jones, Joshua D. 2 Tiendrebéogo, Sylvestre R. M. 3 Sanou, Idrissa 3 Sangaré, Lassana 3 Kouanda, Seni 4 Dabal, Moumouni 3 Lingani, Clement 3 Elie, Cheryl M. 5 Johnson, Scott 5 Ari, Mary 5 Martinez, Joseph 5 Chatt, Julie 5 Sidibe, Kassim 6 Schmink, Susanna 5 Mayer, Leonard W. 5 Kondé, M. Kader 7 Djingarey, Mamoudou H. 8 Popovic, Tanja 5 Plikaytis, Brian D. 5; Affiliation: 1: Division of HIV/AIDS Prevention, Center for Disease Control and Prevention, Mutengene, Cameroon. 2: Indian Health Service, Portland, Oregon. 3: Ministry of Health. 4: Institut de Recherche en Sciences Sanitaires, Multidisease Surveillance Center, Ouagadougou, Burkina Faso. 5: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 6: Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia. 7: Meningitis Vaccine Program,World Health Organization, Harare, Zimbabwe. 8: World Health Organization Regional Office for Africa, Multidisease Surveillance Center, Ouagadougou, Burkina Faso.; Source Info: 3/1/2006, Vol. 193 Issue 5, p607; Subject Term: IMMUNITY; Subject Term: EPIDEMICS; Subject Term: NEISSERIA meningitidis; Subject Term: SERUM; Subject Term: COMMUNICABLE diseases; Subject Term: BURKINA Faso; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mazzuckelli, Lawrence F.
AU - Methner, Mark M.
AU - Achutan, Chandran
T1 - Case Study.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/03//
VL - 3
IS - 3
M3 - Article
SP - 28
EP - 32
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents a case study of a health hazard evaluation (HHE) of a steel ladder fabrication plant by the U.S. National Institute for Occupational Safety and Health (NIOSH). The inspection was to gauge employee exposures to hexamethylene diisocyanate (HDI) during spray painting operations in one of the largest heavy steel fabrication specialists in the Midwest.
KW - Occupational hazards
KW - Industrial safety
KW - Case studies
KW - United States
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 75127675; Mazzuckelli, Lawrence F. 1; Methner, Mark M. 1; Achutan, Chandran 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Mar2006, Vol. 3 Issue 3, p28; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial safety; Subject Term: Case studies; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/15459620500513295
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106422313
T1 - Airborne hexamethylene diisocyanate and particulate matter exposures during fire/rescue vehicle ladder finishing operations.
AU - Methner MM
AU - Achutan C
A2 - Mazzuckelli LF
Y1 - 2006/03//
N1 - Accession Number: 106422313. Language: English. Entry Date: 20060407. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Occupational Exposure
KW - Organic Chemicals
KW - Particulate Matter
KW - Case Studies
KW - National Institute for Occupational Safety and Health
KW - United States
KW - Human
SP - D28
EP - 32
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16423809.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106422313&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taiwo, Oyebode A.
AU - Sircar, Kanta D.
AU - Slade, Martin D.
AU - Cantley, Linda F.
AU - Vegso, Sally J.
AU - Rabinowitz, Peter M.
AU - Fiellin, Martha G.
AU - Cullen, Mark R.
T1 - Incidence of Asthma Among Aluminum Workers.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/03//
VL - 48
IS - 3
M3 - Article
SP - 275
EP - 282
SN - 10762752
AB - Exposures to respiratory irritants encountered in aluminum smelters in Europe, Australia, and New Zealand have been suggested as the cause of "potroom asthma." However, there remains disagreement in North America regarding the existence of this entity. This study was designed to assess whether asthma occurs excessively among potroom workers and if so, delineate dose-response relationships for possible causal risk factors. The asthma incidence ratio between potroom and nonpotroom workers after adjusting for smoking was 1.40. Although bivariate analyses showed a relationship between asthma incidence and exposure to total fluoride, gaseous fluoride, particulate fluoride, sulfur dioxide, and smoking, only the effects of gaseous fluoride (relative risk [RR] = 5.1) and smoking (RR] = 7.7) remained significant in a multivariate model. Potroom asthma appears to occur at the studied US. aluminum smelters at doses within regulatory guidelines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASTHMA
KW - OBSTRUCTIVE lung diseases
KW - ALUMINUM smelting
KW - ALUMINUM industry
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL diseases
KW - EUROPE
KW - AUSTRALIA
KW - NEW Zealand
N1 - Accession Number: 20448660; Taiwo, Oyebode A. 1; Email Address: Oyebode.taiwo@yale.edu Sircar, Kanta D. 1,2 Slade, Martin D. 1 Cantley, Linda F. 1 Vegso, Sally J. 1 Rabinowitz, Peter M. 1 Fiellin, Martha G. 1 Cullen, Mark R. 1; Affiliation: 1: Yale University School of Medicine, New Haven, Connecticut 2: Respiratory Disease Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Mar2006, Vol. 48 Issue 3, p275; Subject Term: ASTHMA; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: ALUMINUM smelting; Subject Term: ALUMINUM industry; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL diseases; Subject Term: EUROPE; Subject Term: AUSTRALIA; Subject Term: NEW Zealand; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331315 Aluminum Sheet, Plate, and Foil Manufacturing; NAICS/Industry Codes: 331314 Secondary Smelting and Alloying of Aluminum; NAICS/Industry Codes: 331313 Alumina Refining and Primary Aluminum Production; NAICS/Industry Codes: 331318 Other Aluminum Rolling, Drawing, and Extruding; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1097/01.jom.0000197876.31901.f5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Voss, Lesley
AU - Campbell, Mary
AU - Tildesley, Christine
AU - Hay, Deborah
AU - Vaughan, Anne
AU - Thornley, Craig
T1 - Paediatric tuberculosis in a Pacific Islands community in New Zealand.
JO - Journal of Paediatrics & Child Health
JF - Journal of Paediatrics & Child Health
Y1 - 2006/03//
VL - 42
IS - 3
M3 - Article
SP - 118
EP - 122
PB - Wiley-Blackwell
SN - 10344810
AB - Objectives: To describe the demographic, clinical and management aspects of an outbreak of tuberculosis (TB) within a paediatric Pacific Island community in Auckland, New Zealand, in 2002–2003. Methods: The index and source case are described along with details of the extensive contact tracing that was undertaken in this community. Results: A total of 24 children were diagnosed with TB over an 11-month period. All cases were found to be epidemiologically linked to the one source case, mother of the index case. This total included 22 children with pulmonary disease, 1 case of miliary disease (index case) and 1 of cervical adenitis. Only 58% had symptoms at diagnosis and only 5 presented to medical attention with symptoms, the remainder had symptoms disclosed after contact tracing occurred. The Mycobacterium tuberculosis isolate was fully sensitive and all children (excluding the child with miliary disease) received short course directly observed therapy. One child developed hepatotoxicity requiring modification of his drug regimen. Conclusions: Children are at high risk of developing active disease after exposure to TB. The study describes the minimal symptoms manifested in many of the children with significant radiological changes consistent with pulmonary TB. This highlights the need to consider Mantoux testing and chest X-rays for children presenting with persistent respiratory symptoms in high-risk populations. Issues of contact tracing and adherence were also a problem in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Paediatrics & Child Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS in children
KW - PEDIATRIC respiratory diseases
KW - LUNG diseases
KW - MYCOBACTERIUM tuberculosis
KW - EPIDEMIOLOGY
KW - AUCKLAND (N.Z.)
KW - NEW Zealand
KW - adherence
KW - children
KW - disease outbreaks
KW - New Zealand
KW - tuberculosis
N1 - Accession Number: 19826133; Voss, Lesley 1; Email Address: lesleyv@adhb.govt.nz Campbell, Mary 2 Tildesley, Christine 2 Hay, Deborah 2 Vaughan, Anne 3 Thornley, Craig 2; Affiliation: 1: Paediatric Infectious Diseases, Starship Children's Hospital, Auckland, New Zealand 2: Auckland Regional Public Health Service, Auckland, New Zealand 3: LabPlus, Auckland City Hospital, Auckland District Health Board, Auckland, New Zealand; Source Info: Mar2006, Vol. 42 Issue 3, p118; Subject Term: TUBERCULOSIS in children; Subject Term: PEDIATRIC respiratory diseases; Subject Term: LUNG diseases; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: EPIDEMIOLOGY; Subject Term: AUCKLAND (N.Z.); Subject Term: NEW Zealand; Author-Supplied Keyword: adherence; Author-Supplied Keyword: children; Author-Supplied Keyword: disease outbreaks; Author-Supplied Keyword: New Zealand; Author-Supplied Keyword: tuberculosis; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1111/j.1440-1754.2006.00809.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105887914
T1 - Initiating transformational change to enhance patient safety.
AU - Henriksen K
AU - Keyes MA
AU - Stevens DM
AU - Clancy CM
Y1 - 2006/03//
N1 - Accession Number: 105887914. Language: English. Entry Date: 20080418. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Leadership
KW - Organizational Change
KW - Patient Safety
KW - Quality Improvement
KW - Commitment
KW - Economic Competition
KW - Ethics, Professional
KW - Goals and Objectives
KW - Hospital Restructuring
KW - Learning Environment
KW - Organizational Culture
KW - Problem Identification
KW - Trust
SP - 20
EP - 24
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 2
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The paper focuses on the need for transformational change to enhance patient safety and examines lessons learned as found in the management and transformational change literature-a literature that may be new to patient safety researchers, administrators, and care providers. Transformational change is a daunting undertaking as many chief executive officers have found as they try to revitalize and transform their organizations to a rapidly changing global marketplace. Significant transformational change also is needed in health care. The paper explores what transformational change means with respect to patient safety and quality initiatives. It draws on the transformational change literature to help identify the distinguishing features of successful transformations and provides emerging findings and examples in health care that illustrate transformational concepts in practice.
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, Department of Health and Human Services, 640 Gaither Road, Rockville, MD 20850; Kerm.Henriksen@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - CASE
AU - Joskow, Renée
AU - Barr, Dana Boyd
AU - Barr, John R.
AU - Calafat, Antonia M.
AU - Needham, Larry L.
AU - Rubin, Carol
T1 - Exposure to bisphenol A from bis-glycidyl dimethacrylate-based dental sealants.
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2006/03//
VL - 137
IS - 3
M3 - Case Study
SP - 353
EP - 362
SN - 00028177
AB - The article focuses on the study that assesses the risk of human exposure to Bisphenol A (BPA), an element of composites and sealants, used in dentistry in the U.S. The American Dental Association (ADA) affirmed that sealants with Seal of Acceptance do not discharge BPA substance. A study enrolled by 15 persons, provided with Helioseal F or Delton Light Cure (LC) sealants was implemented. It showed that BPA leach increased from Delton LC since it has no ADA seal.
KW - BISPHENOL A
KW - DENTAL materials
KW - DENTISTRY
KW - SEALING compounds
KW - UNITED States
KW - Bisphenol A
KW - dental sealants
KW - mass spectrometry
KW - saliva
KW - urine
N1 - Accession Number: 20542231; Joskow, Renée 1 Barr, Dana Boyd 2; Email Address: dbarr@cdc.gov Barr, John R. 3 Calafat, Antonia M. 4 Needham, Larry L. 5 Rubin, Carol 6; Affiliation: 1: Commander, U.S. Public Health Service, Office of Force Readiness and Deployment, Office of the Surgeon General, Office of the Secretary, U.S. Department of Health and Human Services, Rockville, Md. 2: Chief, Pesticide Laboratory, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Highway, Mailstop F17, Atlanta, Ga. 3: Chief, Biological Mass Spectrometry Laboratory, Centers for Disease Control and Prevention, National Center for Environmental Health. Division of Laboratory Sciences, Atlanta 4: Chief, Personal Care Products Laboratory, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta 5: Chief, Organic Analytical Toxicology Branch, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta 6: Chief, Health Studies Branch, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Health and Hazard Evaluation, Atlanta; Source Info: Mar2006, Vol. 137 Issue 3, p353; Subject Term: BISPHENOL A; Subject Term: DENTAL materials; Subject Term: DENTISTRY; Subject Term: SEALING compounds; Subject Term: UNITED States; Author-Supplied Keyword: Bisphenol A; Author-Supplied Keyword: dental sealants; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: saliva; Author-Supplied Keyword: urine; NAICS/Industry Codes: 325520 Adhesive Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 10p; Illustrations: 2 Charts, 3 Graphs; Document Type: Case Study
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106317021
T1 - Exposure to bisphenol A from bis-glycidyl dimethacrylate-based dental sealants.
AU - Joskow R
AU - Barr DB
AU - Barr JR
AU - Calafat AM
AU - Needham LL
AU - Rubin C
Y1 - 2006/03//
N1 - Accession Number: 106317021. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Martin MD. Exposure to Bisphenol A (BPA) from dental sealants is detectable in saliva and urine, and varies significantly between sealant formulations. (J EVID BASED DENT PRACT) Jun2007; 7 (2): 79-80. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7503060.
KW - Composite Resins
KW - Environmental Exposure
KW - Pit and Fissure Sealants
KW - Analytic Research
KW - Case Control Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Evaluation Research
KW - Male
KW - Pretest-Posttest Design
KW - Saliva -- Analysis
KW - Sample Size
KW - Statistical Significance
KW - T-Tests
KW - Urinalysis
KW - Human
SP - 353
EP - 362
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 137
IS - 3
CY - Chicago, Illinois
PB - American Dental Association
AB - Background. Bisphenol A (BPA) is a common component of composites and dental sealants. The potential exists for human exposure after sealant placement.Methods. The authors prospectively enrolled 15 men in an exposure assessment study; 14 completed the study. After placement of clinically appropriate amounts of one of two sealants, the authors measured BPA in saliva and urine samples collected at prescribed intervals after the sealants were placed. They used selective and sensitive isotope-dilution mass-spectrometry-based methods for BPA measurements, thus providing the most reliable results.Results. Helioseal F (Ivoclar Vivadent, Amherst, N.Y.) leached negligible amounts of BPA. Urinary and salivary BPA levels in subjects who received these sealants were similar to baseline levels. Delton Light Cure (LC) Opaque pit-and-fissure sealant (Dentsply/Ash, York, Pa.) leached more BPA, resulting in low-level BPA exposures similar to those used in laboratory animal testing. BPA exposure after Delton LC sealant placement was significantly higher than exposure after placement of Helioseal F. Patients treated with Delton LC had significantly higher doses of BPA (110 µg) than did those treated with Helioseal F (5.5 µg) (P < .0001).Conclusions. Placement of clinically relevant amounts of Delton LC sealant resulted in low-level BPA exposure; however, exposure was negligible after placement of Helioseal F. Saliva collection after sealant placement likely reduced systemic absorption of BPA from dental sealants. Sealants should remain a useful part of routine preventive dental practice, especially those that leach negligible amounts of BPA.Clinical Implications. Dental sealants may be a point source for low-level BPA exposure at levels that show health effects in rodents. Further research is required to determine whether human exposure to BPA at these levels causes adverse effects.
SN - 0002-8177
AD - Commander, U.S. Public Health Service, Office of Force Readiness and Deployment, Office of the Surgeon General, Office of the Secretary, U.S. Department of Health and Human Services, Rockville, MD
U2 - PMID: 16570469.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Foundations for a Healthier United States
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/03//
VL - 106
IS - 3
M3 - Editorial
SP - 341
EP - 341
SN - 00028223
N1 - Accession Number: 19847156; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Mar2006, Vol. 106 Issue 3, p341; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2006.01.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106456597
T1 - From the Surgeon General. Foundations for a healthier United States.
AU - Carmona RH
Y1 - 2006/03//
N1 - Accession Number: 106456597. Language: English. Entry Date: 20060616. Revision Date: 20150711. Publication Type: Journal Article; editorial; pictorial; website. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Health Promotion
KW - Information Resources
KW - World Wide Web
KW - Dietitians
KW - Food Guide Pyramid
KW - Healthy People 2010
KW - Nutrition
KW - Osteoporosis -- Prevention and Control
SP - 341
EP - 341
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
U2 - PMID: 16503215.
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DB - rzh
ER -
TY - JOUR
AU - Hudson, Diana
AU - Nilsen, Per
AU - Dahl, Eilif
AU - Mode, Nicolle
AU - Ekman, Robert
T1 - Factors Associated With Injuries Occurring Aboard Vessels in Alaska: Differences Between Residents and Nonresidents.
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
Y1 - 2006/03//Mar/Apr2006
VL - 13
IS - 2
M3 - Article
SP - 67
EP - 72
SN - 11951982
AB - Background. Over the past decade, visitors to Alaska have spent increasing amounts of time engaged in water-based recreational activities aboard vessels of various sizes. Serious vessel-related injuries to travelers in Alaska involve not only medical care from unfamiliar health care providers and facilities but also entail the loss of vacation time and the need for injured travelers to return to their homes under less than optimal traveling conditions. Methods. This study employed a retrospective, case-comparison analysis to identify differences in factors associated with recreational injuries acquired aboard watercraft that resulted in hospitalizations of residents and nonresidents of Alaska during 1991 to 2000. Tests of proportions were conducted to elucidate differences in demographic characteristics and injury precursors between the two subgroups. Specific injury outcomes were then tested for significance using odds ratios. Results. Alaska residents and nonresidents demonstrated significant differences for both demographic factors and factors describing events leading to injuries, and for injury outcomes. Nonresidents were more likely to be 65 years or older, female, and aboard cruise ships when injuries occurred. Nonresidents were more likely to suffer fracture injuries, to suffer injuries with Abbreviated Injury Scores greater than 2, to experience posthospital discharges to sites other than their homes, and to experience postinjury disabilities. Conclusions. Alaska residents and nonresidents in this study showed significant differences in demographics, precipitating events, and injury outcomes. The findings lend support for targeted safety promotion programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Travel Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - MEDICAL emergencies
KW - PASSENGER ships
KW - TRAVEL -- Health aspects
KW - RECREATION
KW - HOSPITALS -- Admission & discharge
KW - SAFETY
KW - DISABILITIES
KW - ALASKA
N1 - Accession Number: 20069262; Hudson, Diana 1 Nilsen, Per 2 Dahl, Eilif 3 Mode, Nicolle 4 Ekman, Robert 1,5; Affiliation: 1: Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden 2: Department of Health and Society, Division of Social Medicine and Public Health Science, Linköping Universitet, Linköping, Sweden 3: Department of Surgery, The National Hospital (Rikshospitalet), Oslo, Norway 4: Alaska Field Station, National Institute for Occupational Safety and Health, Anchorage, Alaska 5: Swedish Rescue Services Agency, NCO, Swedish Center for Lessons Learned from Incidents & Accidents, Skövde, Sweden; Source Info: Mar/Apr2006, Vol. 13 Issue 2, p67; Subject Term: WOUNDS & injuries; Subject Term: MEDICAL emergencies; Subject Term: PASSENGER ships; Subject Term: TRAVEL -- Health aspects; Subject Term: RECREATION; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: SAFETY; Subject Term: DISABILITIES; Subject Term: ALASKA; NAICS/Industry Codes: 336611 Ship Building and Repairing; NAICS/Industry Codes: 483112 Deep Sea Passenger Transportation; NAICS/Industry Codes: 483114 Coastal and Great Lakes Passenger Transportation; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1708-8305.2006.00018.x
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ER -
TY - JOUR
AU - Khurana, Surender
AU - Needham, James
AU - Mathieson, Bonnie
AU - Rodriguez-Chavez, Isaac R.
AU - Catanzaro, Andrew T.
AU - Bailer, Robert T.
AU - Kim, Jerome
AU - Polonis, Vicky
AU - Cooper, David A.
AU - Guerin, Jan
AU - Peterson, Michael L.
AU - Gurwith, Marc
AU - Nguyen, Nga
AU - Graham, Barney S.
AU - Golding, Hana
T1 - Human Immunodeficiency Virus (HIV) Vaccine Trials: a Novel Assay for Differential Diagnosis of HIV Infections in the Face of Vaccine-Generated Antibodies.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/03//
VL - 80
IS - 5
M3 - Article
SP - 23
EP - 23
SN - 0022538X
AB - All current human immunodeficiency virus (HIV) vaccine candidates contain multiple viral components and elicit antibodies that react positively in licensed HIV diagnostic tests, which contain similar viral products. Thus, vaccine trial participants could be falsely diagnosed as infected with HIV. Additionally, uninfected, seropositive vaccinees may encounter long-term social and economic harms. Moreover, this also interferes with early detection of true HIV infections during preventive HIV vaccine trials. An HIV-seropositive test result among uninfected vaccine trial participants is a major public health concern for volunteers who want to participate in future HIV vaccine trials. Based on the increased number of HIV vaccines being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Using a whole-HIV-genome phage display library, we identified conserved sequences in Env-gp41 and Gag-p6 which are recognized soon after infection, do not contain protective epitopes, and are not part of most current HIV vaccines. We established a new HIV serodetection assay based on these peptides. To date, this assay, termed HIV-SELECTEST, demonstrates >99% specificity and sensitivity. Importantly, in testing of plasma samples from multiple HIV vaccine trials, uninfected trial participants scored negative, while all intercurrent infections were detected within 1 to 3 months of HIV infection. The new HIV-SELECTEST is a simple but robust diagnostic tool for easy implementation in HIV vaccine trials and blood banks worldwide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - VIRAL vaccines
KW - IMMUNOGLOBULINS
KW - VACCINES
KW - AIDS (Disease) -- Vaccination
N1 - Accession Number: 20839280; Khurana, Surender 1 Needham, James 1 Mathieson, Bonnie 2 Rodriguez-Chavez, Isaac R. 3 Catanzaro, Andrew T. 4 Bailer, Robert T. 4 Kim, Jerome 5 Polonis, Vicky 6 Cooper, David A. 7 Guerin, Jan 7 Peterson, Michael L. 8 Gurwith, Marc 8 Nguyen, Nga 9 Graham, Barney S. 4 Golding, Hana 1; Email Address: goldingh@cber.FDA.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, Maryland 20892 2: Office of AIDS Research, NIH, Bethesda, Maryland 20892 3: Vaccine Clinical Research Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 4: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 5: U.S. Army Medical Component-Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), APO AP 96546 6: U.S. Military HIV Research Program, Rockville, Maryland 20850 7: National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia 2010 8: VaxGen, Inc., Brisbane, California 94005 9: Core Facility, Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, Maryland 20892; Source Info: Mar2006, Vol. 80 Issue 5, p23; Subject Term: HIV (Viruses); Subject Term: VIRAL vaccines; Subject Term: IMMUNOGLOBULINS; Subject Term: VACCINES; Subject Term: AIDS (Disease) -- Vaccination; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.80.5.2092-2099.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Joo-Yeon
AU - Kim, Cheon-Jei
AU - Kunz, Benno
T1 - Identification of lactic acid bacteria isolated from kimchi and studies on their suitability for application as starter culture in the production of fermented sausages
JO - Meat Science
JF - Meat Science
Y1 - 2006/03//
VL - 72
IS - 3
M3 - Article
SP - 437
EP - 445
SN - 03091740
AB - Abstract: The aim of the investigation was to identify strains of lactobacilli coming from kimchi with properties suitable for use as starter cultures in sausage fermentation. A total of 31 strains of lactobacilli were isolated from kimchi on the 4–6th day of fermentation at 20°C using MRS agar plates and identified on the basis of morphological, biochemical, and physiological characteristics. The isolates were identified as Leuconostoc mes.mes./dent (12.9%), Lactobacillus curvatus (9.7%), Lactobacillus brevis (35.5%), Lactobacillus sake (25.8%), and Lactobacillus plantarum (16.1%). Thus, 51.6% of the isolates were homo-fermentative or facultative hetero-fermentative bacteria and the rest (48.4%) were hetero-fermentative bacteria. Among them L. brevis, L. curvatus, L. plantarum, and L. sake were investigated for their growth profile and metabolism characteristics in the fluid (submerged) model-medium modified according to the special conditions of fermented sausages. Relatively good growth properties were found for L. brevis, L. plantarum, and L. sake with maximum numbers of 8.18, 8.51 and 8.17cfu/ml, respectively, whereas L. curvatus could not adapt to the special environmental conditions. Regarding souring properties, L. brevis showed little ability to decrease pH, whereas L. curvatus, L. plantarum, and L. sake showed relatively good acidifying properties. According to the results of glucose fermentation and its products, only L. plantarum exhibited homo-fermentative characteristics. As a result only L. plantarum among the isolates from kimchi had an ability to adapt to the complex environment of fermented sausage, which will thereby allow them to act as starter cultures and natural preservatives in sausage production. [Copyright &y& Elsevier]
AB - Copyright of Meat Science is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LACTOBACILLUS
KW - INDUSTRIAL microbiology
KW - PROKARYOTES
KW - HYDROGEN-ion concentration
KW - *Fermented sausage
KW - Identification
KW - Kimchi
KW - Lactic acid starter culture
N1 - Accession Number: 19201889; Lee, Joo-Yeon 1; Email Address: foodjooyeon@naver.com Kim, Cheon-Jei 2 Kunz, Benno 3; Affiliation: 1: Korea Food and Drug Administration, Division of Food Standard, Center for Food Standard Evaluation, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-704, Republic of Korea 2: Department of Food Science and Biotechnology of Animal Resources, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea 3: Department of Food Technology, University of Bonn, Roemerstrasse 164, D-53117 Bonn, Germany; Source Info: Mar2006, Vol. 72 Issue 3, p437; Subject Term: LACTOBACILLUS; Subject Term: INDUSTRIAL microbiology; Subject Term: PROKARYOTES; Subject Term: HYDROGEN-ion concentration; Author-Supplied Keyword: *Fermented sausage; Author-Supplied Keyword: Identification; Author-Supplied Keyword: Kimchi; Author-Supplied Keyword: Lactic acid starter culture; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.meatsci.2005.08.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106347622
T1 - Health care expenditure burdens among adults with diabetes in 2001.
AU - Bernard DM
AU - Banthin JS
AU - Encinosa WE
Y1 - 2006/03//
N1 - Accession Number: 106347622. Language: English. Entry Date: 20061013. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Diabetes Mellitus -- Economics
KW - Health Services Accessibility -- Evaluation
KW - Adult
KW - Aged
KW - Descriptive Statistics
KW - Female
KW - Insurance, Health
KW - Male
KW - Middle Age
KW - Socioeconomic Factors
KW - Human
SP - 210
EP - 215
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: High out-of-pocket costs can pose a significant burden on patients with chronic conditions such as diabetes and contribute to decreased treatment adherence. We examined financial burdens among adults with diabetes using nationally representative data. METHODS: estimated how frequently adults with diabetes live in families in which spending on health insurance premiums and health care services exceed a specified percentage of family-level after-tax disposable income. RESULTS: We found that adults with diabetes face greater risks of high burdens compared with adults with any other highly prevalent medical condition. Adults with diabetes have lower incomes and pay a higher share of total expenditures out-of-pocket compared with adults with heart disease, hypertension, and cancer. Among adults with diabetes, women, those who live in poverty, and those with coexisting conditions are more likely to bear high burdens. Among nonelderly adults, those with public coverage and the uninsured have greater risk of high burdens compared with those with private insurance. More than 23% of the uninsured and more than 20% of those with public coverage spend more than half of their disposable income on health care. Among the elderly, those with private nonemployment related insurance have the greatest risk of high burdens followed by those with Medicare only, those with private employment-related coverage, and those enrolled in Medicaid. Prescription medications and diabetic supplies account for 63% to 70% of out-of-pocket expenditures among the nonelderly and 62% to 69% among the elderly. CONCLUSIONS: Our study identifies the subpopulations among adults with diabetes who are more likely to have high burdens, so that intervention measures can be targeted to help reduce treatment noncompliance. Our analysis also emphasizes the role of medications and diabetic supplies in contributing to high out-of-pocket burdens.
SN - 0025-7079
AD - Division of Modeling and Simulation, Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; dbernard@ahrq.gov
U2 - PMID: 16501391.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baker, Brent A.
AU - Rao, K. M. K.
AU - Mercer, Robert R.
AU - Geronilla, Ken B.
AU - Kashon, Mike L.
AU - Miller, Gerald R.
AU - Cutlip, Robert G.
T1 - Quantitative Histology and MGF Gene Expression in Rats following SSC Exercise In Vivo.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2006/03//
VL - 38
IS - 3
M3 - Article
SP - 463
EP - 471
SN - 01959131
AB - Purpose: We investigated the effects of muscle length during stretch-shortening cycles (SSC) in vivo on changes in MGF gene expression and quantitative morphometry in rat skeletal muscle. Methods: Dorsiflexor muscles of male Sprague-Dawley rats were exposed to seven sets of 10 SSC at 500°·s-1. Animals were randomly assigned to a long muscle length injury group (L-inj), short muscle length injury group (S-inj), or isometric group (Iso), with recoveries examined at 6 or 48 h post-injury for each group. Following exposure, animals were euthanized, and the tissue was prepared for either histology (quantitative morphometry) or RNA isolation, followed by quantitative real-time reverse transcriptase polymerase chain reaction, mRNA levels were measured for mechano-growth factor (MGF), while 18S ribosomal RNA served as the internal reference sample. Results: Stereological measures indicative of edema and myofiber degeneration were significantly increased in the L-inj SSC group at 48 h when compared with the S-inj or Iso group. MGF mRNA was increased transiently at 6 h in the isometric group. In contrast, MGF mRNA was increased at 48 h in the S-inj, but was not increased at either time point in the L-inj group. Conclusion: These data strongly indicate that exposure to SSC at longer muscle lengths result in greater morphometric indices of inflammation and degeneration than SSC conducted at a shorter muscle lengths or isometric contractions, at the same time that the adaptation to SSC was prolonged and, apparently, not resolved in the L-inj group that was manifested by the lack of up-regulation in MGF mRNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medicine & Science in Sports & Exercise is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - MUSCLE contraction
KW - GENETIC regulation
KW - MUSCLES
KW - BIOSYNTHESIS
KW - POLYMERASE chain reaction
KW - POLYMERIZATION
KW - NUCLEIC acids
KW - MESSENGER RNA
KW - mRNA EXPRESSION
KW - MUSCLE INJURY
KW - STEREOLOGY
KW - STRETCH-SHORTENING CYCLES
N1 - Accession Number: 20408062; Baker, Brent A. 1 Rao, K. M. K. 1 Mercer, Robert R. 1 Geronilla, Ken B. 1 Kashon, Mike L. 1 Miller, Gerald R. 1 Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV; Source Info: Mar2006, Vol. 38 Issue 3, p463; Subject Term: GENE expression; Subject Term: MUSCLE contraction; Subject Term: GENETIC regulation; Subject Term: MUSCLES; Subject Term: BIOSYNTHESIS; Subject Term: POLYMERASE chain reaction; Subject Term: POLYMERIZATION; Subject Term: NUCLEIC acids; Subject Term: MESSENGER RNA; Author-Supplied Keyword: mRNA EXPRESSION; Author-Supplied Keyword: MUSCLE INJURY; Author-Supplied Keyword: STEREOLOGY; Author-Supplied Keyword: STRETCH-SHORTENING CYCLES; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1249/01.mss.0000191419.67030.69
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106311953
T1 - Quantitative histology and MGF gene expression in rats following SSC exercise in vivo.
AU - Baker BA
AU - Rao KMK
AU - Mercer RR
AU - Geronilla KB
AU - Kashon ML
AU - Miller GR
AU - Cutlip RG
Y1 - 2006/03//
N1 - Accession Number: 106311953. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8005433.
KW - Muscle, Skeletal -- Physiology
KW - Muscle Strengthening
KW - Exercise Physiology
KW - Genes -- Physiology
KW - Growth Substances
KW - Animal Studies
KW - Rats
KW - Descriptive Statistics
KW - In Vivo Studies
KW - Data Analysis Software
KW - Two-Way Analysis of Variance
KW - Post Hoc Analysis
KW - Kruskal-Wallis Test
KW - Nonparametric Statistics
KW - Mann-Whitney U Test
SP - 463
EP - 471
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
JA - MED SCI SPORTS EXERC
VL - 38
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE: We investigated the effects of muscle length during stretch-shortening cycles (SSC) in vivo on changes in MGF gene expression and quantitative morphometry in rat skeletal muscle. METHODS: Dorsiflexor muscles of male Sprague-Dawley rats were exposed to seven sets of 10 SSC at 500 degrees .s(-1). Animals were randomly assigned to a long muscle length injury group (L-inj), short muscle length injury group (S-inj), or isometric group (Iso), with recoveries examined at 6 or 48 h post-injury for each group. Following exposure, animals were euthanized, and the tissue was prepared for either histology (quantitative morphometry) or RNA isolation, followed by quantitative real-time reverse transcriptase polymerase chain reaction. mRNA levels were measured for mechano-growth factor (MGF), while 18S ribosomal RNA served as the internal reference sample. RESULTS: Stereological measures indicative of edema and myofiber degeneration were significantly increased in the L-inj SSC group at 48 h when compared with the S-inj or Iso group. MGF mRNA was increased transiently at 6 h in the isometric group. In contrast, MGF mRNA was increased at 48 h in the S-inj, but was not increased at either time point in the L-inj group. CONCLUSION: These data strongly indicate that exposure to SSC at longer muscle lengths result in greater morphometric indices of inflammation and degeneration than SSC conducted at a shorter muscle lengths or isometric contractions, at the same time that the adaptation to SSC was prolonged and, apparently, not resolved in the L-inj group that was manifested by the lack of up-regulation in MGF mRNA.
SN - 0195-9131
AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV
U2 - PMID: 16540833.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Salotra, Poonam
AU - Duncan, Robert C.
AU - Singh, Ruchi
AU - Subba Raju, B.V.
AU - Sreenivas, Gannavaram
AU - Nakhasi, Hira L.
T1 - Upregulation of surface proteins in Leishmania donovani isolated from patients of post kala-azar dermal leishmaniasis
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/03//
VL - 8
IS - 3
M3 - Article
SP - 637
EP - 644
SN - 12864579
AB - Abstract: Five to fifteen percent of visceral leishmaniasis (VL) patients in India develop post kala-azar dermal leishmaniasis (PKDL), usually 1–2years after apparent clinical cure. There is evidence pointing to a role played by the host immune responses in the disease pathogenesis, however, the contribution of changes in parasite gene expression has not been explored. Highly sensitive gene expression microarray technology was employed to identify genes that are differentially expressed in Leishmania parasites isolated from PKDL patients in comparison with those from VL. Hybridization on Leishmania donovani genomic microarray comprised of unique clones allowed us to identify 46/2268 (2%) clones that showed statistically significant (P <0.05) changes in expression (1.5–3.5-fold) in parasites of PKDL origin compared to those of VL origin. Sequence analysis of six genomic clones, consistently showing approximately 2-fold higher expression in PKDL parasites, revealed significant homology with gp63, gp46, putative amastin, a putative reductase and a possible calpain-like protein. The gene products showing upregulated expression in PKDL isolates may be candidates playing a role in the altered clinical manifestation in PKDL. Such differentially expressed genes hold the key to understanding the parasite genetic factors that contribute to the persistence after clinical cure of VL. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Leishmania
KW - Trypanosomatidae
KW - Gene expression
KW - Genomic microarray
KW - Leishmania donovani
KW - PKDL
KW - Visceral leishmaniasis
N1 - Accession Number: 20557642; Salotra, Poonam 1; Email Address: salotra@vsnl.com; Duncan, Robert C. 2; Singh, Ruchi 1; Subba Raju, B.V. 1; Sreenivas, Gannavaram 1; Nakhasi, Hira L. 2; Affiliations: 1: Molecular Biology Laboratory, Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India; 2: Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Issue Info: Mar2006, Vol. 8 Issue 3, p637; Thesaurus Term: Immune response; Subject Term: Leishmania; Subject Term: Trypanosomatidae; Subject Term: Gene expression; Author-Supplied Keyword: Genomic microarray; Author-Supplied Keyword: Leishmania donovani; Author-Supplied Keyword: PKDL; Author-Supplied Keyword: Visceral leishmaniasis; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.micinf.2005.08.018
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Collazo, Carmen M.
AU - Sher, Alan
AU - Meierovics, Anda I.
AU - Elkins, Karen L.
T1 - Myeloid differentiation factor-88 (MyD88) is essential for control of primary in vivo Francisella tularensis LVS infection, but not for control of intramacrophage bacterial replication
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/03//
VL - 8
IS - 3
M3 - Article
SP - 779
EP - 790
SN - 12864579
AB - Abstract: The means by which Francisella tularensis, the causative agent of tularemia, are recognized by mammalian immune systems are poorly understood. Here we wished to explore the contribution of the MyD88/Toll-like receptor signaling pathway in initiating murine responses to F. tularensis Live Vaccine Strain (LVS). MyD88 knockout (KO) mice, but not TLR2-, TLR4- or TLR9-deficient mice, rapidly succumbed following in vivo bacterial infection via the intradermal route even with a very low dose of LVS (5×101) that was 100,000-fold less than the LD50 of normal wild-type (WT) mice. By day 5 after LVS infection, bacterial organ burdens were 5–6 logs higher in MyD88 knockout mice; further, unlike infected WT mice, levels of interferon-γ in the sera of LVS-infected MyD88 KO were undetectable. An in vitro culture system was used to assess the ability of bone marrow macrophages derived from either KO or WT mice to support bacterial growth, or to control intracellular bacterial replication when co-cultured with immune lymphocytes. In this assay, bacterial replication was similar in macrophages derived from either WT or any of the TLR KO mice. Bacterial growth was controlled in co-cultures containing macrophages from MyD88 KO mice or TLR KO mice as well as in co-cultures containing immune WT splenic lymphocytes and WT macrophages. Further, MyD88-deficient LVS-immune splenocytes controlled intracellular growth comparably to those from normal mice. Thus MyD88 is essential for innate host resistance to LVS infection, but is not required for macrophage control of intracellular bacterial growth. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbial growth
KW - Tumor necrosis factor
KW - Francisella tularensis
KW - Preventive medicine
KW - Bacterial infections
KW - bone marrow derived macrophages ( BMMØ )
KW - colony forming units ( CFU )
KW - Immunology
KW - interferon ( IFN )
KW - interleukin ( IL )
KW - intradermal ( i.d. )
KW - intraperitoneal ( i.p. )
KW - knockout ( KO )
KW - lethal dose 50 ( LD50 )
KW - Live Vaccine Strain ( LVS )
KW - Toll-like receptor ( TLR )
KW - Toll-like receptors
KW - tumor necrosis factor ( TNF )
KW - wild type ( WT )
N1 - Accession Number: 20557658; Collazo, Carmen M. 1; Sher, Alan 2; Meierovics, Anda I. 1; Elkins, Karen L. 1; Email Address: karen.elkins@fda.hhs.gov; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA; 2: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 6148, Building 50, 50 South Drive, Bethesda, MD 20892-8003, USA; Issue Info: Mar2006, Vol. 8 Issue 3, p779; Thesaurus Term: Microbial growth; Subject Term: Tumor necrosis factor; Subject Term: Francisella tularensis; Subject Term: Preventive medicine; Author-Supplied Keyword: Bacterial infections; Author-Supplied Keyword: bone marrow derived macrophages ( BMMØ ); Author-Supplied Keyword: colony forming units ( CFU ); Author-Supplied Keyword: Immunology; Author-Supplied Keyword: interferon ( IFN ); Author-Supplied Keyword: interleukin ( IL ); Author-Supplied Keyword: intradermal ( i.d. ); Author-Supplied Keyword: intraperitoneal ( i.p. ); Author-Supplied Keyword: knockout ( KO ); Author-Supplied Keyword: lethal dose 50 ( LD50 ); Author-Supplied Keyword: Live Vaccine Strain ( LVS ); Author-Supplied Keyword: Toll-like receptor ( TLR ); Author-Supplied Keyword: Toll-like receptors; Author-Supplied Keyword: tumor necrosis factor ( TNF ); Author-Supplied Keyword: wild type ( WT ); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.micinf.2005.09.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hu, Lan
AU - McDaniel, James P.
AU - Kopecko, Dennis J.
T1 - Signal transduction events involved in human epithelial cell invasion by Campylobacter jejuni 81-176
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2006/03//
VL - 40
IS - 3
M3 - Article
SP - 91
EP - 100
SN - 08824010
AB - Abstract: Analyses of invasive enteric bacteria (e.g. Shigella, Salmonella, Listeria, and Campylobacter) have shown that these pathogens initiate orchestrated signal transduction cascades in host cells leading to host cytoskeletal rearrangements that result in bacterial uptake. This current study was specifically aimed at examining the involvement of host membrane caveolae and certain protein kinases in epithelial cell invasion by C. jejuni strain 81-176, for which we have previously characterized the kinetics of entry and a unique microtubule-dependent mechanism of internalization. Utilizing in vitro cultured cell invasion assays with a gentamicin-kill step, disruption of membrane caveolae by pretreatment of INT407 cell monolayers with filipin III reduced C. jejuni 81-176 entry by >95%. Strain 81-176 uptake into INT407 cells was markedly inhibited by monolayer pretreatment with the protein kinase inhibitors genistein and staurosporine, or specific inhibitors of PI 3-kinase, wortmannin and LY294002. Western blot analysis using monoclonal anti-protein tyrosine phosphorylation antibody revealed distinctive changes during invasion in phosphorylation of at least nine proteins. Further inhibitor studies indicated that heterotrimeric G proteins, plus ERK and p38 MAP kinase activation are also involved in C. jejuni 81-176 invasion. These results suggest that C. jejuni 81-176 interact at host cell surface membrane caveolae with G protein-coupled receptors, which presumably trigger G-proteins and kinases to activate host proteins including PI 3-kinase and MAP kinases, that appear to be intimately involved in the events controlling 81-176 internalization. [Copyright &y& Elsevier]
AB - Copyright of Microbial Pathogenesis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic microorganisms
KW - Microbial invasiveness
KW - Cellular signal transduction
KW - Epithelial cells
KW - Campylobacter jejuni
KW - G protein
KW - Invasion
KW - Phosphorylation
KW - Signal transduction
N1 - Accession Number: 19683993; Hu, Lan 1; McDaniel, James P. 1; Kopecko, Dennis J.; Email Address: kopecko@cber.fda.gov; Affiliations: 1: Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, FDA, NIH Campus Building 29/420, 29 Lincoln Drive, Bethesda, MD 20892, USA; Issue Info: Mar2006, Vol. 40 Issue 3, p91; Thesaurus Term: Pathogenic microorganisms; Subject Term: Microbial invasiveness; Subject Term: Cellular signal transduction; Subject Term: Epithelial cells; Author-Supplied Keyword: Campylobacter jejuni; Author-Supplied Keyword: G protein; Author-Supplied Keyword: Invasion; Author-Supplied Keyword: Phosphorylation; Author-Supplied Keyword: Signal transduction; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.micpath.2005.11.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ellwood, Kathleen C.
T1 - What Are Qualified Health Claims?
JO - Nutrition Today
JF - Nutrition Today
Y1 - 2006/03//Mar/Apr2006
VL - 41
IS - 2
M3 - Article
SP - 56
EP - 61
SN - 0029666X
AB - The article provides some insights into qualified health claims in the U.S. Health claims were first authorized through the Nutrition Labeling and Education Act of 1990. Several court decisions directed the U.S. Food and Drug Administration to provide for qualified health claims on dietary supplements. The Consumer Health Information for Better Nutrition Initiative provided for the use of qualified health claims for both conventional human foods and dietary supplements.
KW - CLAIMS
KW - FOOD labeling -- Law & legislation
KW - DIETARY supplements -- Law & legislation
KW - CONSUMER protection
KW - FOOD industry
KW - JUDGMENTS (Law)
KW - UNITED States
N1 - Accession Number: 25637103; Ellwood, Kathleen C. 1; Affiliation: 1: Director, Division of Nutrition Programs and Labeling, Office of Nutritional Products, Labeling and Dietary Supplements, US Food and Drug Administration's Center for Food Safety and Applied Nutrition; Source Info: Mar/Apr2006, Vol. 41 Issue 2, 1 p56; Subject Term: CLAIMS; Subject Term: FOOD labeling -- Law & legislation; Subject Term: DIETARY supplements -- Law & legislation; Subject Term: CONSUMER protection; Subject Term: FOOD industry; Subject Term: JUDGMENTS (Law); Subject Term: UNITED States; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106459665
T1 - What are qualified health claims?
AU - Ellwood KC
Y1 - 2006/03//Mar/Apr2006
N1 - Accession Number: 106459665. Language: English. Entry Date: 20060623. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0055201.
KW - Food Labeling -- Legislation and Jurisprudence
KW - Consumer Health Information -- Legislation and Jurisprudence
KW - United States Food and Drug Administration -- Legislation and Jurisprudence
KW - United States
KW - Dietary Supplementation -- Legislation and Jurisprudence
SP - 56
EP - 61
JO - Nutrition Today
JF - Nutrition Today
JA - NUTR TODAY
VL - 41
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Health claims were first authorized through the Nutrition Labeling and Education Act of 1990. The standard that the Congress set for scientific evidence for the claim was the significant scientific agreement standard. This standard was challenged by several manufacturers of dietary supplements. Several court decisions directed the US Food and Drug Administration to provide for qualified health claims on dietary supplements. In December 2002, a major new initiative, 'The Consumer Health Information for Better Nutrition Initiative,' was announced by the Food and Drug Administration. This initiative provided for the use of qualified health claims for both conventional human foods and dietary supplements. The process for reviewing the scientific evidence for a claim reaching significant scientific agreement and for those that require qualifying language is the same. The Food and Drug Administration must determine the claim language and disclaimer for each claim. Several letters of enforcement discretion for qualified health claims have been issued by the Food and Drug Administration.
SN - 0029-666X
AD - Director, Division of Nutrition Programs and Labeling, Office of Nutritional Products, Labeling and Dietary Supplements, US Food and Drug Administration's Center for Food Safety and Applied Nutrition, HFS-830 5100 Paint Branch Parkway, College Park, MD 20740
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105928095
T1 - Musculoskeletal disorders and their after-effects among health professionals in Beijing.
AU - Smith DR
AU - Zhang X
AU - Zheng Y
AU - Zhang B
AU - Wang R
Y1 - 2006/03//
N1 - Accession Number: 105928095. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Instrumentation: Standardised Nordic Questionnaire for the Analysis of Muscoloskeletal Symptoms [adapted]. NLM UID: 9808465.
KW - Health Personnel -- China
KW - Musculoskeletal System -- Pathology -- China
KW - Occupational Diseases -- Complications -- China
KW - Occupational Diseases -- Epidemiology -- China
KW - Adult
KW - Body Mass Index -- Evaluation
KW - Body Weights and Measures
KW - Chi Square Test
KW - China
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Disease Duration
KW - Epidemiological Research
KW - Female
KW - Logistic Regression
KW - Low Back Pain
KW - Male
KW - Neck Pain
KW - Occupational Diseases -- Therapy
KW - Occupational Health
KW - Odds Ratio
KW - One-Way Analysis of Variance
KW - Questionnaires
KW - Sex Factors
KW - Shoulder Pain
KW - Sick Leave
KW - Smoking
KW - Human
SP - 25
EP - 34
JO - Occupational Ergonomics
JF - Occupational Ergonomics
JA - OCCUP ERGON
VL - 6
IS - 1
PB - IOS Press
AB - Although musculoskeletal disorders (MSD) represent an important occupational issue worldwide, surprisingly few investigations have been conducted among white-collar workers in Mainland China. The current study examined MSD and their after-effects among 334 health professionals in Beijing, by means of an anonymous questionnaire (response rate: 99.4%). Of the respondents, 92.2% reported an MSD occurring in the previous 12 months, with the neck (72.2%), shoulder and lower back (59.9% each) being the most commonly affected body sites. Fifty-six percent of all MSD had persisted > 24 hours, 23.0% had interfered with their work ability and 15.9% required medical treatment. MSD of the hand/wrist and MSD of the shoulders were the most likely to last > 24 hours. MSD of the lower back, upper legs or hand/wrist were all associated with a reduction of work ability. Medical treatment was more likely to have been sought for MSD of the lower back or knees, when compared to other body sites. Females were five times more likely to report an MSD at any body site, while tobacco smokers were three times more likely to have sought medical treatment for an MSD. Overall, this study suggests that MSD are becoming an increasingly important cause of functional disability among white-collar workers in China. As some significant correlations were found during statistical analysis, further research should now investigate the complicity of various factors on MSD development within this emerging Chinese demographic.
SN - 1359-9364
AD - International Centre for Research Promotion and Informatics, Japan National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; smith@h.jniosh.go.jp
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Calzone, Kathleen
AU - Jenkins, Jean
AU - Badzek, Laurie
AU - Constantin, Carolyn
AU - Debisette, Annette
AU - Feetham, Suzanne
AU - Geolot, Denise
AU - Hagan, Pamela
AU - Hess, Madeleine
AU - Lea, Dale
AU - Lewis, Judith
AU - Nesseler, Kerry
AU - Potempa, Kathleen
AU - Prows, Cynthia
AU - Thomson, Elizabeth
AU - Tinkle, Melinda
AU - Williams, Janet
T1 - ESTABLISHING ESSENTIAL NURSING COMPETENCIES AND CURRICULA GUIDELINES FOR GENETICS AND GENOMICS.
JO - Oncology Nursing Forum
JF - Oncology Nursing Forum
Y1 - 2006/03//
VL - 33
IS - 2
M3 - Article
SP - 419
EP - 419
PB - Oncology Nursing Society
SN - 0190535X
AB - The rapid translation of genetic and genomic science to clinical care has major implications for the nursing profession that has limited preparation in genetics. In response to this deficit, an initiative was launched to define the essential genetic and genomic competencies for all registered nurses regardless of academic preparation, role or clinical specialty. The purpose of the competencies are to guide academic curriculum content/learning activities based on the current state of the evidence and guide the continuing education and specialty certification of practicing registered nurses. The ultimate goal is to prepare the entire nursing workforce to deliver genetically and genomically competent healthcare. To establish the essential competencies, a Steering Committee (SC) of federal, academic and national leaders in nursing was established which identified, reviewed, analyzed, and compared competencies recommended in existing published and peer reviewed documents (including NCHPEG Competencies). A writing team from the SC was selected and the first draft of the competencies was completed and reviewed/approved by the SC. The proposed competencies were then presented for critique to nurse representatives to NCHPEG in January 2005 with revisions integrated. The revised essential competencies were then posted for public comment at http://NursingWorld.org/practice with announcements to the American Nurses Association (ANA), its constituent members and organizational affiliates, and other nursing organizations requesting their comments, then reviewed and incorporated. An invitational meeting was held September 21-22, 2005 of key stakeholders in collaboration with the ANA. Fifty participants reviewed, discussed, and modified the document with ultimate consensus on the competencies achieved. An action plan is in progress for endorsement, integration of the competencies into curricula, the NCLEX examination, specialty certification processes, continuing education and accreditation. We will report on the details of the competency development and consensus process, the status of the competencies, endorsement, and integration plans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncology Nursing Forum is the property of Oncology Nursing Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING -- Study & teaching
KW - NURSING -- Practice
KW - CANCER genetics
KW - MOLECULAR genetics
KW - MEDICAL care
N1 - Accession Number: 26746739; Calzone, Kathleen 1 Jenkins, Jean 2 Badzek, Laurie 3 Constantin, Carolyn 4 Debisette, Annette 5 Feetham, Suzanne 5 Geolot, Denise 3 Hagan, Pamela 3 Hess, Madeleine 5 Lea, Dale 2 Lewis, Judith 6 Nesseler, Kerry 5 Potempa, Kathleen 7 Prows, Cynthia 8 Thomson, Elizabeth 2 Tinkle, Melinda 9 Williams, Janet 10; Affiliation: 1: National Cancer Institute, CCR-Genetics Branch, Bethesda, MD 2: National Human Genome Research Institute, Bethesda, MD 3: American Nurses Association, Silver Spring, MD 4: Centers for Disease Control and Prevention, Atlanta, GA 5: Health Resources and Services Administration, Rockville, MD 6: Virginia Commonwealth University, Richmond, VA 7: Oregon Health and Science University, Portland, OR 8: Cincinnati Childrens Hospital Medical Center, Cincinnati, OH 9: National Institute of Nursing Research, Bethesda, MD 10: University of Iowa, Iowa City, IA; Source Info: Mar2006, Vol. 33 Issue 2, p419; Subject Term: NURSING -- Study & teaching; Subject Term: NURSING -- Practice; Subject Term: CANCER genetics; Subject Term: MOLECULAR genetics; Subject Term: MEDICAL care; Number of Pages: 1/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salerno, R. A.
AU - Lesko, L. J.
T1 - Three years of promise, proposals, and progress on optimizing the benefit/risk of medicines: a commentary on the 3rd FDA-DIA-PWG-PhRMA-BIO pharmacogenomics workshop.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/03//
VL - 6
IS - 2
M3 - Article
SP - 78
EP - 81
PB - Nature Publishing Group
SN - 1470269X
AB - Deals with the workshops on pharmacogenetics and pharmacogenomics sponsored by the U.S. Food and Drug Administration and industry groups held in April 2005 in Bethesda, Maryland. Origins of the workshop; Workshop organization; Topics discussed in plenary sessions.
KW - SEMINARS
KW - PHARMACOGENOMICS
KW - BIOCHEMICAL genetics
KW - GENETICS
KW - MEDICAL genetics
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20179523; Salerno, R. A. 1; Email Address: salernr@wyeth.com Lesko, L. J. 2; Email Address: leskol@cder.fda.gov; Affiliation: 1: Worldwide Regulatory Affairs, Pharma & Translational Medicine, Wyeth Research, College, PA, USA 2: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Source Info: 2006, Vol. 6 Issue 2, p78; Subject Term: SEMINARS; Subject Term: PHARMACOGENOMICS; Subject Term: BIOCHEMICAL genetics; Subject Term: GENETICS; Subject Term: MEDICAL genetics; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Document Type: Article
L3 - 10.1038/sj.tpj.6500345
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20179523&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, S-J
AU - Cohen, N.
AU - Katz, D. A.
AU - Ruano, G.
AU - Shaw, P. M.
AU - Spear, B.
T1 - Retrospective validation of genomic biomarkers – what are the questions, challenges and strategies for developing useful relationships to clinical outcomes – workshop summary.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/03//
VL - 6
IS - 2
M3 - Article
SP - 82
EP - 88
PB - Nature Publishing Group
SN - 1470269X
AB - Reports on the workshop on "Retrospective Validation of Genetic Biomarkers--What are the Questions, Challenges and Strategies for Developing Useful Relationships to Clinical Outcomes" held in Rockville, Maryland in April 2005. Changes proposed by the U.S. Food and Drug Administration in the process of drug development; Approach to confirming the pharmacogenetic value of genetic biomarkers; Value of using retrospective clinical data in conducting the prospective genetic analysis.
KW - BIOCHEMICAL markers
KW - GENETICS
KW - SEMINARS
KW - DRUG development
KW - PHARMACY
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20179515; Wang, S-J 1; Email Address: wangs@cder.fda.gov Cohen, N. 2 Katz, D. A. 3 Ruano, G. 4 Shaw, P. M. 5 Spear, B. 3; Affiliation: 1: Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA 2: Johnson and Johnson Pharmaceutical R&D, Raritan, NJ, USA 3: Abbott Laboratories, Abbott Park, IL, USA 4: Genomas Inc., Hartford, CT, USA 5: Merck & Corporation, Bluebell, PA, USA; Source Info: 2006, Vol. 6 Issue 2, p82; Subject Term: BIOCHEMICAL markers; Subject Term: GENETICS; Subject Term: SEMINARS; Subject Term: DRUG development; Subject Term: PHARMACY; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1038/sj.tpj.6500363
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20179515&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trepicchio, W. L.
AU - Essayan, D.
AU - Hall, S. T.
AU - Schechter, G.
AU - Tezak, Z.
AU - Wang, S. J.
AU - Weinreich, D.
AU - Simon, R.
T1 - Designing prospective clinical pharmacogenomic (PG) trials: meeting report on drug development strategies to enhance therapeutic decision making.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/03//
VL - 6
IS - 2
M3 - Article
SP - 89
EP - 94
PB - Nature Publishing Group
SN - 1470269X
AB - Reports on a meeting aimed at addressing the issues involved in designing prospective pharmacogenomic clinical trials. Overview of the development of a pharmacogenomic profile; Prospective use of genetic markers in phase III clinical trials; Prospective use of biomarkers during early development.
KW - PHARMACOGENOMICS
KW - GENETIC markers
KW - BIOCHEMICAL markers
KW - CLINICAL trials
KW - MEDICAL experimentation on humans
N1 - Accession Number: 20179524; Trepicchio, W. L. 1; Email Address: wtrepicchio@mpi.com Essayan, D. 2 Hall, S. T. 3 Schechter, G. 4 Tezak, Z. 5 Wang, S. J. 6 Weinreich, D. 7 Simon, R. 8; Affiliation: 1: Division of Molecular Medicine, Millennium Pharmaceuticals, Cambridge, MA, USA 2: Regulatory Affairs, Amgen, Thousand Oaks, CA, USA 3: US Regulatory Affairs, GlaxoSmithKline, Research Triangle Park, NC, USA 4: FDA Center for Biologics Evaluation and Research, Rockville, MD, USA 5: FDA Center for Devices and Radiological Health, Office of In Vitro Diagnostic Devices Evaluation and Safety (OIVD), Rockville, MD, USA 6: FDA Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Rockville, MD, USA 7: GeneLogic Inc., Gaithersburg, MD, USA 8: Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA; Source Info: 2006, Vol. 6 Issue 2, p89; Subject Term: PHARMACOGENOMICS; Subject Term: GENETIC markers; Subject Term: BIOCHEMICAL markers; Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1038/sj.tpj.6500344
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106170826
T1 - Changes in service delivery following HIV/AIDS education of medical and mental health service providers: results of a one-year follow-up.
AU - Cook JA
AU - Razzano LA
AU - Linsk N
AU - Dancy BL
AU - Grey DD
AU - Butler SB
AU - Mitchell CG
AU - Despotes J
Y1 - 2006///Spring2006
N1 - Accession Number: 106170826. Language: English. Entry Date: 20071012. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Cooperative Agreement #1T16 SM19940. NLM UID: 9601800.
KW - Clinical Competence
KW - Education, Continuing
KW - Health Care Delivery
KW - Health Personnel -- Education
KW - HIV Infections -- Psychosocial Factors
KW - HIV Infections -- Therapy
KW - Confidence Intervals
KW - Counseling -- Education
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Logistic Regression
KW - Male
KW - Mental Health Services
KW - Middle Age
KW - Multivariate Analysis
KW - Odds Ratio
KW - P-Value
KW - Paired T-Tests
KW - Pilot Studies
KW - Pretest-Posttest Design
KW - Questionnaires
KW - Human
SP - 282
EP - 288
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 29
IS - 4
CY - Washington, District of Columbia
PB - American Psychological Association
AB - This study examined changes in service delivery patterns of health and mental health service providers one year after a training on the fundamentals of HIV/AIDS and mental health. Paired t-tests for 424 training recipients showed significant increases in delivery of HIV-related services, and these remained significant while controlling for additional training, job changes, region (urban, rural, suburban), and provider discipline. Multiple logistic regression analysis revealed a significantly greater likelihood of providing direct services to HIV+ individuals among male providers, those with more years of HIV experience, those in counseling disciplines, and those working in a new job since the training.
SN - 1095-158X
AD - Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois, Chicago 60603, USA. cook@ripco.com
U2 - PMID: 16689039.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106170826&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106170828
T1 - Predictors of mental health services use among lesbian and heterosexual women.
AU - Razzano LA
AU - Cook JA
AU - Hamilton MM
AU - Hughes TL
AU - Matthews AK
Y1 - 2006///Spring2006
N1 - Accession Number: 106170828. Language: English. Entry Date: 20071012. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Instrumentation: National Study of Health and Life Experiences of Women-modified (NSHLEW) (Wilsnack et al). NLM UID: 9601800.
KW - Heterosexuality
KW - Lesbians -- Psychosocial Factors
KW - Mental Health Services -- Utilization
KW - Adult
KW - Chi Square Test
KW - Descriptive Statistics
KW - Female
KW - Interviews
KW - Logistic Regression
KW - P-Value
KW - Pearson's Correlation Coefficient
KW - Questionnaires
KW - Research Instruments
KW - Social Class
KW - Socioeconomic Factors
KW - T-Tests
KW - United States
KW - Human
SP - 289
EP - 298
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 29
IS - 4
CY - Washington, District of Columbia
PB - American Psychological Association
AB - Studies examining mental health services have identified a series of indicators with demonstrated effects on services access, barriers, and utilization, including gender, race/ethnicity, and socioeconomic status, as well as indicators such as type of insurance, client attitudes toward mental health, and diagnosis. This study identifies predictors of mental health services utilization in a diverse community sample of lesbians and heterosexual women (N=120). Outcomes for study participants are compared to those found in the services utilization literature, and similarities and differences among lesbians and heterosexual women are examined. Suggestions are offered for identifying new factors in mental health service utilization among groups with diverse sexual orientations.
SN - 1095-158X
AD - Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 60603, USA. Razzano@psych.uic.edu
U2 - PMID: 16689040.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106170828&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106465882
T1 - Availability of behavioral health treatment for women in prison.
AU - Blitz CL
AU - Wolff N
AU - Paap K
AU - Blitz, Cynthia L
AU - Wolff, Nancy
AU - Paap, Kris
Y1 - 2006/03//
N1 - Accession Number: 106465882. Language: English. Entry Date: 20060630. Revision Date: 20161114. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: P-20-MH-66170/MH/NIMH NIH HHS/United States. NLM UID: 9502838.
KW - Health Services Accessibility
KW - Mental Health Services
KW - Prisoners
KW - Women
KW - Confidence Intervals
KW - Data Collection Methods
KW - Descriptive Statistics
KW - Female
KW - Logistic Regression
KW - Male
KW - New Jersey
KW - Odds Ratio
KW - P-Value
KW - Funding Source
KW - Human
SP - 356
EP - 360
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 57
IS - 3
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Objectives: This study examined whether women with behavioral health needs are more likely to receive treatment for these problems in prison or in the community and to what extent prison disrupts or establishes involvement in treatment for these women.Methods: Data were collected in August 2004 as part of a population survey of female inmates in the only state correctional facility for women in New Jersey.Results: A total of 908 women were surveyed. Fifty-six percent of the women surveyed reported needing behavioral health treatment before incarceration, but only 62 percent of this group reported receiving such treatment in the community. The rate at which treatment matched need within this population before incarceration varied by type of treatment needed: it was the highest (58 percent) for women who needed treatment for mental health problems, lower (52 percent) for those who needed substance abuse treatment, and lowest (44 percent) for those who needed treatment for comorbid mental health and substance abuse problems. In comparison, the rate of match between need for and receipt of treatment in prison was higher for all three types of behavioral health treatment (78 percent, 57 percent, and 65 percent, respectively). Additionally, the findings suggest that prison did not disrupt the type of behavioral health treatment that inmates had previously received in the community.Conclusions: At least in New Jersey, prison appears to improve access to behavioral health treatment among female inmates. Although this conclusion is consistent with the rehabilitation goals of incarceration, it also suggests that some women may have been able to avoid prison if treatment had been provided in the community, especially for substance-related problems.
SN - 1075-2730
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, New Jersey 08901, USA
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ 08901; clblitz@rci.rutgers.edu
U2 - PMID: 16524993.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lobato, Mark N.
AU - Yong-Cheng Wang
AU - Becerra, Jose E.
AU - Simone, Patricia M.
AU - Castro, Kenneth G.
T1 - Improved Program Activities Are Associated with Decreasing Tuberculosis Incidence in the United States.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/03//Mar/Apr2006
VL - 121
IS - 2
M3 - Article
SP - 108
EP - 115
SN - 00333549
AB - Objective. This study was conducted to determine whether improvements in tuberculosis (TB) program activities correlate with incident TB cases. Methods. National TB surveillance data and program data from patients with pulmonary and laryngeal TB and their contacts were collected. These data were analyzed using regression models to assess the association between changes in incident TB cases and indicators of program performance (a time series of percent changes in program indices). Results, A total of 1,361,113 contacts exposed to 150,668 TB patients were identified through contact investigations From 1987 to 1992 (the period of TB resurgence and antedating increased funding), there was a decline in several measures used by TB programs for outcomes of contact investigations. From 1993 to 1998 (the period after increases in TB funds), there was an observable improvement in the program indices. Four program indices for contacts and two for TB cases (directly observed therapy and completion of therapy) were statistically associated (p≤0.01) with the decline in TB incident cases. Conclusions. These analyses suggest that expanded TB program activities resulted in the reduction in national TB cases and underscore the importance of treatment completion for TB disease and latent TB infection. Based on these results, we propose that further improvements in these activities will accelerate the decline of TB in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS
KW - REGRESSION analysis
KW - THERAPEUTICS
KW - COMMUNICABLE diseases
KW - UNITED States
N1 - Accession Number: 20335879; Lobato, Mark N. 1; Email Address: mn10@cdc.gov Yong-Cheng Wang 1,2 Becerra, Jose E. 1 Simone, Patricia M. 1,3 Castro, Kenneth G. 1; Affiliation: 1: Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 2: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 3: Division of Global Migration and Quarantine, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA; Source Info: Mar/Apr2006, Vol. 121 Issue 2, p108; Subject Term: TUBERCULOSIS; Subject Term: REGRESSION analysis; Subject Term: THERAPEUTICS; Subject Term: COMMUNICABLE diseases; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eaglestaff, Mary Lynn
AU - Klug, Marilyn G.
AU - Burd, Larry
T1 - Infant Mortality Reviews in the Aberdeen Area of the Indian Health Service: Strategies and Outcomes.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/03//Mar/Apr2006
VL - 121
IS - 2
M3 - Article
SP - 140
EP - 148
SN - 00333549
AB - Objective. To determine cause and manner of death for consecutive infant deaths in the Aberdeen Area of the Indian Health Service (AAIHS) from 1998 to 2002 and to identify risk markers for infant mortality. Methods. Infant deaths in the AAIHS were identified from four data sources: death certificates from the four states in the AAIHS, deaths reported by local IHS Service Units, from obituaries in local and regional newspapers, and deaths reported by area hospitals. Each infant death is then sent to the local IHS service unit for review, where data from the infant and mother's chart is extracted and recorded. Local community factors, birth and death certificates, and autopsy reports are collected. The case is then reviewed at the Perinatal Infant Mortality Review (PIMR) meeting and a cause and manner of death is assigned. Summary data for the cohort was examined and then compared by mortality category and three age-at-death groups. Results. Sudden infant death syndrome accounted for 33% of all infant deaths in the AAIHS. Prematurity was the second most prevalent cause-specific mortality category, accounting for 22% of all infant deaths. The authors found that infant mortality was surprisingly recurrent, with 32% of mothers of this infant having had a previous infant death. Conclusions. The PIMR committee requires substantial resources to support a review committee with appropriate expertise and their travel. Participation of local IHS staff and tribal members provides an important cultural and community perspective for the review process. Quality improvement changes are currently being implemented. These include increasing data on substance use, mental health needs, and reviews of fetal deaths. The process of mortality review has been very helpful in public education in the AAIHS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT mortality
KW - NEWSPAPERS
KW - HOSPITALS
KW - AUTOPSY
KW - OBITUARIES
N1 - Accession Number: 20335884; Eaglestaff, Mary Lynn 1 Klug, Marilyn G. 2 Burd, Larry 2; Email Address: laburd@medicine.nodak.edu; Affiliation: 1: Aberdeen Area of the Indian Health Service, Aberdeen, SD 2: Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND; Source Info: Mar/Apr2006, Vol. 121 Issue 2, p140; Subject Term: INFANT mortality; Subject Term: NEWSPAPERS; Subject Term: HOSPITALS; Subject Term: AUTOPSY; Subject Term: OBITUARIES; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 511110 Newspaper Publishers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 519110 News Syndicates; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106447371
T1 - Infant mortality reviews in the Aberdeen Area of the Indian Health Service: strategies and outcomes.
AU - EagleStaff ML
AU - Klug MG
AU - Burd L
Y1 - 2006/03//Mar/Apr2006
N1 - Accession Number: 106447371. Language: English. Entry Date: 20060526. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Epidemiology -- Methods
KW - Health Services, Indigenous -- South Dakota
KW - Infant Mortality -- Epidemiology -- South Dakota
KW - Infant Mortality -- Risk Factors -- South Dakota
KW - Age Factors
KW - Birth Weight
KW - Cause of Death
KW - Chi Square Test
KW - Committees
KW - Death Certificates
KW - Descriptive Statistics
KW - Female
KW - Gestational Age
KW - Hospitals
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Medical Records
KW - Newspapers
KW - One-Way Analysis of Variance
KW - Pregnancy
KW - Prenatal Care
KW - Prevalence
KW - Record Review
KW - Recurrence
KW - South Dakota
KW - Substance Abuse
KW - Sudden Infant Death -- Epidemiology
KW - Human
SP - 140
EP - 148
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 121
IS - 2
PB - Sage Publications Inc.
AB - OBJECTIVE: To determine cause and manner of death for consecutive infant deaths in the Aberdeen Area of the Indian Health Service (AAIHS) from 1998 to 2002 and to identify risk markers for infant mortality. METHODS: Infant deaths in the AAIHS were identified from four data sources: death certificates from the four states in the AAIHS, deaths reported by local IHS Service Units, from obituaries in local and regional newspapers, and deaths reported by area hospitals. Each infant death is then sent to the local IHS service unit for review, where data from the infant and mother's chart is extracted and recorded. Local community factors, birth and death certificates, and autopsy reports are collected. The case is then reviewed at the Perinatal Infant Mortality Review (PIMR) meeting and a cause and manner of death is assigned. Summary data for the cohort was examined and then compared by mortality category and three age-at-death groups. RESULTS: Sudden infant death syndrome accounted for 33% of all infant deaths in the AAIHS. Prematurity was the second most prevalent cause-specific mortality category, accounting for 22% of all infant deaths. The authors found that infant mortality was surprisingly recurrent, with 32% of mothers of this infant having had a previous infant death. CONCLUSIONS: The PIMR committee requires substantial resources to support a review committee with appropriate expertise and their travel. Participation of local IHS staff and tribal members provides an important cultural and community perspective for the review process. Quality improvement changes are currently being implemented. These include increasing data on substance use, mental health needs, and reviews of fetal deaths. The process of mortality review has been very helpful in public education in the AAIHS.
SN - 0033-3549
AD - Aberdeen Area of the Indian Health Service, Aberdeen, SD
U2 - PMID: 16528946.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Cimino, Michael C.
AU - Benz, R. Daniel
AU - Contrera, Joseph F.
T1 - An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/03//
VL - 44
IS - 2
M3 - Article
SP - 83
EP - 96
SN - 02732300
AB - Abstract: A retrospective analysis of standard genetic toxicity (genetox) tests, reproductive and developmental toxicity (reprotox) studies, and rodent carcinogenicity bioassays (rcbioassay) was performed to identify the genetox and reprotox endpoints whose results best correlate with rcbioassay observations. A database of 7205 chemicals with genetox (n =4961), reprotox (n =2173), and rcbioassay (n =1442) toxicity data was constructed; 1112 of the chemicals have both genetox and rcbioassay data and 721 chemicals have both reprotox and rcbioassay data. This study differed from previous studies by using conservative weight of evidence criteria to classify chemical carcinogens, data from 63 genetox and reprotox toxicological endpoints, and a new statistical parameter of correlation indicator (CI, the average of specificity and positive predictivity) to identify good surrogate endpoints for predicting carcinogenicity. Among 63 endpoints, results revealed that carcinogenicity was well correlated with certain tests for gene mutation (n =8), in vivo clastogenicity (n =2), unscheduled DNA synthesis assay (n =1), and reprotox (n =3). The current FDA regulatory battery of four genetox tests used to predict carcinogenicity includes two tests with good correlation (gene mutation in Salmonella and in vivo micronucleus) and two tests with poor correlation (mouse lymphoma gene mutation and in vitro chromosome aberrations) by our criteria. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Carcinogenicity
KW - Hazardous substances
KW - Biological assay
KW - Database
KW - Genetic toxicity
KW - Genetox
KW - Reproductive and developmental toxicity
KW - Reprotox
KW - Rodent carcinogenicity bioassay
KW - Surrogate
N1 - Accession Number: 19767002; Matthews, Edwin J. 1; Email Address: matthewse@cder.fda.gov; Kruhlak, Naomi L. 1; Cimino, Michael C. 2; Benz, R. Daniel 1; Contrera, Joseph F. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; 2: US Environmental Protection Agency (7403M), 1200 Pennsylvania Avenue, NW, Washington, DC 20460, USA; Issue Info: Mar2006, Vol. 44 Issue 2, p83; Thesaurus Term: Mutation (Biology); Thesaurus Term: Carcinogenicity; Thesaurus Term: Hazardous substances; Thesaurus Term: Biological assay; Author-Supplied Keyword: Database; Author-Supplied Keyword: Genetic toxicity; Author-Supplied Keyword: Genetox; Author-Supplied Keyword: Reproductive and developmental toxicity; Author-Supplied Keyword: Reprotox; Author-Supplied Keyword: Rodent carcinogenicity bioassay; Author-Supplied Keyword: Surrogate; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19767002&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Cimino, Michael C.
AU - Benz, R. Daniel
AU - Contrera, Joseph F.
T1 - An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/03//
VL - 44
IS - 2
M3 - Article
SP - 97
EP - 110
SN - 02732300
AB - Abstract: This study examined a novel method to identify carcinogens that employed expanded data sets composed of in silico data pooled with actual experimental genetic toxicity (genetox) and reproductive and developmental toxicity (reprotox) data. We constructed 21 modules using the MC4PC program including 13 of 14 (11 genetox and 3 reprotox) tests that we found correlated with results of rodent carcinogenicity bioassays (rcbioassays) [Matthews, E.J., Kruhlak, N.L., Cimino, M.C., Benz, R.D., Contrera, J.F., 2005b. An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints. Regul. Toxicol. Pharmacol.]. Each of the 21 modules was evaluated by cross-validation experiments and those with high specificity (SP) and positive predictivity (PPV) were used to predict activities of the 1442 chemicals tested for carcinogenicity for which actual genetox or reprotox data were missing. The expanded data sets had ∼70% in silico data pooled with ∼30% experimental data. Based upon SP and PPV, the expanded data sets showed good correlation with carcinogenicity testing results and had correlation indicator (CI, the average of SP and PPV) values of 75.5–88.7%. Conversely, expanded data sets for 9 non-correlated test endpoints were shown not to correlate with carcinogenicity results (CI values <75%). Results also showed that when Salmonella mutagenic carcinogens were removed from the 12 correlated, expanded data sets, only 7 endpoints showed added value by detecting significantly more additional carcinogens than non-carcinogens. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity
KW - Hazardous substances
KW - Biological assay
KW - Chemical terrorism
KW - Computational toxicology
KW - Genetic toxicity
KW - Genetox
KW - MC4PC
KW - Predictive modeling
KW - Quantitative structure–activity relationships
KW - Reproductive and developmental toxicity
KW - Reprotox
KW - Rodent carcinogenicity bioassay
KW - Surrogate
N1 - Accession Number: 19767003; Matthews, Edwin J. 1; Email Address: matthewse@cder.fda.gov; Kruhlak, Naomi L. 1; Cimino, Michael C. 2; Benz, R. Daniel 1; Contrera, Joseph F. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; 2: US Environmental Protection Agency (7403M), 1200 Pennsylvania Avenue, NW, Washington, DC 20460, USA; Issue Info: Mar2006, Vol. 44 Issue 2, p97; Thesaurus Term: Carcinogenicity; Thesaurus Term: Hazardous substances; Thesaurus Term: Biological assay; Thesaurus Term: Chemical terrorism; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Genetic toxicity; Author-Supplied Keyword: Genetox; Author-Supplied Keyword: MC4PC; Author-Supplied Keyword: Predictive modeling; Author-Supplied Keyword: Quantitative structure–activity relationships; Author-Supplied Keyword: Reproductive and developmental toxicity; Author-Supplied Keyword: Reprotox; Author-Supplied Keyword: Rodent carcinogenicity bioassay; Author-Supplied Keyword: Surrogate; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.yrtph.2005.10.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19767003&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bailey, Allan B.
AU - Chanderbhan, Ronald
AU - Collazo-Braier, Nancy
AU - Cheeseman, M.A.
AU - Twaroski, Michelle L.
T1 - Erratum to “The use of structure–activity relationship analysis in the food contact notification program” [Regul. Toxicol. Pharmacol. 42 (2005) 225–235]
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/03//
VL - 44
IS - 2
M3 - Correction notice
SP - 190
EP - 190
SN - 02732300
N1 - Accession Number: 19767012; Bailey, Allan B. 1; Chanderbhan, Ronald 1; Collazo-Braier, Nancy; Cheeseman, M.A. 1; Twaroski, Michelle L.; Email Address: Michelle.Twaroski@cfsan.fda.gov; Affiliations: 1: Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA; Issue Info: Mar2006, Vol. 44 Issue 2, p190; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.yrtph.2005.04.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106470749
T1 - A case report: breast cancer metastasis and implications of bony metastasis on activity and ambulation.
AU - McGarvey CL
AU - Gergich NLS
AU - Soballe P
AU - Pfalzer L
Y1 - 2006/03//
N1 - Accession Number: 106470749. Language: English. Entry Date: 20060714. Revision Date: 20150820. Publication Type: Journal Article; algorithm; case study; diagnostic images; tables/charts. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA.
KW - Bone Neoplasms -- Diagnosis
KW - Breast Neoplasms -- Complications
KW - Neoplasm Metastasis -- Diagnosis
KW - Physical Therapy Assessment
KW - Arm
KW - Arthritis, Rheumatoid -- Pathology
KW - Arthritis, Rheumatoid -- Symptoms
KW - Bone Neoplasms -- Pathology
KW - Bone Neoplasms -- Prognosis
KW - Bone Neoplasms -- Symptoms
KW - Breast Neoplasms -- Epidemiology
KW - Breast Neoplasms -- Prognosis
KW - Diagnosis, Differential
KW - Diagnosis, Laboratory
KW - Female
KW - Incidence
KW - Middle Age
KW - Neoplasm Metastasis -- Prognosis
KW - Neoplasm Metastasis -- Symptoms
KW - Osteoarthritis -- Pathology
KW - Osteoarthritis -- Symptoms
KW - Physical Therapists
KW - Radiography
KW - Radiotherapy -- Adverse Effects
SP - 4
EP - 17
JO - Rehabilitation Oncology
JF - Rehabilitation Oncology
JA - REHABIL ONCOL
VL - 24
IS - 1
CY - Alexandria, Virginia
PB - American Physical Therapy Association, Oncology Section
AB - Patients with chronic rheumatological conditions are often referred to physical therapists for management of related impairments. If a patient's medical history includes cancer, a consideration for metastatic disease must be made during the physical therapy (PT) exam process. Failure to do so may result in ineffective or even contraindicated PT. This report describes a 56 y/o female teacher with a history of advanced breast cancer, referred to PT for shoulder pain, limited range of motion (ROM), and work limitations. On exam, the PT was suspicious of metastatic breast cancer and referred the patient for further testing. Imaging studies confirmed bony metastasis and radiation treatment was started. A PT program was then instituted for palliation. A thorough assessment of the patient's cancer history, relative risk of recurrence, and the presence of metastatic disease is essential. The PT differential diagnosis raised concerns about the patient's cancer disease state because the PT had an understanding of the implications of the cancer history and presenting signs and symptoms associated with a presentation of bone metastases.
SN - 2168-3808
AD - CAPT, United States Public Health Service, Rehabilitation Medicine, Bethesda, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hong Wei Yao
AU - Jian Ping Zhu
AU - Meng Hui Zhao
AU - Yuan Lu
T1 - Losartan Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats.
JO - Respiration
JF - Respiration
Y1 - 2006/03//
VL - 73
IS - 2
M3 - Article
SP - 236
EP - 242
SN - 00257931
AB - Background: In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system is also involved in lung fibrogenesis. Objective: To study the effect of losartan, an angiotensin II antagonist, on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism. Methods: Pulmonary fibrosis was induced in SD rats by intratracheal instillation of bleomycin (5 mg·kg–1). Subsequently, the rats received daily losartan (3, 9 and 27 mg·kg–1) or prednisone (20 mg·kg–1) orally. Six rats in each group were sacrificed 14 and 21 days after intratracheal instillation. Hydroxyproline, superoxide dismutase (SOD), and malondialdehyde (MDA) levels in lung tissues were determined by spectroscopy. The levels of TGF-β1 in serum were measured by ELISA. Histological changes in the lungs were evaluated by hematoxylin-eosin stain, and scored. Results: Rat body weight evidently decreased while the indices of lung and hydroxyproline contents in lung tissue were significantly increased 14 and 21 days after intratracheal bleomycin instillation. Inflammatory cell infiltration and fibrotic scores were more prominent in the model group compared to the sham group. Losartan (3, 9 and 27 mg·kg–1, i.g.) apparently attenuated the degree of pulmonary fibrosis. Further study showed that losartan significantly increased SOD levels while it decreased MDA contents in lung homogenates. Serum TGF-β1 levels of pulmonary fibrosis rats were also decreased by losartan. Conclusions: Losartan had an inhibitory effect on bleomycin-induced pulmonary fibrosis, and its effect may be associated with its anti-free radicals and the reduction in TGF-β1. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Respiration is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PULMONARY fibrosis
KW - LUNG diseases
KW - BLEOMYCIN
KW - ANTINEOPLASTIC antibiotics
KW - SUPEROXIDE dismutase
KW - RATS
KW - Bleomycin
KW - Losartan
KW - Malondialdehyde
KW - Pulmonary fibrosis
KW - Superoxide dismutase
KW - TGF- β1
KW - TGF-β1
N1 - Accession Number: 20198682; Hong Wei Yao 1 Jian Ping Zhu 1 Meng Hui Zhao 2 Yuan Lu 2; Affiliation: 1: Zhejiang Respiratory Drug Research Laboratory, Food and Drug Administration of China 2: Physiological Laboratory, Zhejiang University School of Medicine, Hangzhou , China; Source Info: 2006, Vol. 73 Issue 2, p236; Subject Term: PULMONARY fibrosis; Subject Term: LUNG diseases; Subject Term: BLEOMYCIN; Subject Term: ANTINEOPLASTIC antibiotics; Subject Term: SUPEROXIDE dismutase; Subject Term: RATS; Author-Supplied Keyword: Bleomycin; Author-Supplied Keyword: Losartan; Author-Supplied Keyword: Malondialdehyde; Author-Supplied Keyword: Pulmonary fibrosis; Author-Supplied Keyword: Superoxide dismutase; Author-Supplied Keyword: TGF- β1; Author-Supplied Keyword: TGF-β1; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1159/000090140
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20198682&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waters, T.
AU - Yeung, S.
AU - Genaidy, A.
AU - Callaghan, J.
AU - Barriera-Viruet, H.
AU - Abdallah, S.
AU - Kumar, S.
T1 - Cumulative spinal loading exposure methods for manual material handling tasks. Part 2: methodological issues and applicability for use in epidemiological studies.
JO - Theoretical Issues in Ergonomics Science
JF - Theoretical Issues in Ergonomics Science
Y1 - 2006/03//Mar/Apr2006
VL - 7
IS - 2
M3 - Article
SP - 131
EP - 148
SN - 1463922X
AB - Objective : The goal of this paper is to review and discuss methodological issues related to cumulative spinal loading exposure assessment methods. Background : Research has indicated that there likely is an association between integrated spinal loading and lower back pain. A number of studies have been conducted to evaluate cumulative load; however, comparisons between studies is difficult due to the use of different methods for the assessment of cumulative spinal loading. Methods : A comprehensive electronic search was conducted to locate articles dealing with methods of cumulative spinal loading estimation. The articles were evaluated with respect to methods for obtaining postural data, methods for estimating spinal loads, methods for integrating loads over time and spinal load parameters to be measured. Results : Thirteen articles were located. A summary of the methods used to estimate cumulative spinal load is described and evaluated. Conclusions : There is a pressing need for integrated spinal loading methods that are reliable, valid and practical for use in large occupational epidemiological studies. A number of research needs were outlined aimed at improving the ability to use cumulative load to predict risk of low back disorders due to manual material handling. [ABSTRACT FROM AUTHOR]
AB - Copyright of Theoretical Issues in Ergonomics Science is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERIALS handling
KW - BIOMEDICAL engineering
KW - SPINE
KW - BACKACHE
KW - METHODOLOGY
KW - POSTURE
KW - Cumulative spinal loading
KW - Lower back disorders
KW - Manual material handling
N1 - Accession Number: 20573836; Waters, T. 1; Email Address: trw1@cdc.gov Yeung, S. 2 Genaidy, A. 3 Callaghan, J. 4 Barriera-Viruet, H. 3 Abdallah, S. 5 Kumar, S. 6; Affiliation: 1: National Institute for Occupational Safety and Health, MS C24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 3: Industrial and Manufacturing Engineering Program, University of Cincinnati, Cincinnati, OH 45221-0072, USA 4: Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada 5: Department of Aerospace Engineering, University of Cincinnati, Cincinnati, OH 45221-0070, USA 6: Department of Physical Therapy, University of Alberta, Alberta, Canada T6G 2G4; Source Info: Mar/Apr2006, Vol. 7 Issue 2, p131; Subject Term: MATERIALS handling; Subject Term: BIOMEDICAL engineering; Subject Term: SPINE; Subject Term: BACKACHE; Subject Term: METHODOLOGY; Subject Term: POSTURE; Author-Supplied Keyword: Cumulative spinal loading; Author-Supplied Keyword: Lower back disorders; Author-Supplied Keyword: Manual material handling; Number of Pages: 18p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/14639220500111459
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20573836&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106313816
T1 - Cumulative spinal loading exposure methods for manual material handling tasks. Part 1: is cumulative spinal loading associated with lower back disorders?
AU - Waters T
AU - Yeung S
AU - Genaidy A
AU - Callaghan J
AU - Barriera-Viruet H
AU - Deddens J
Y1 - 2006/03//Mar/Apr2006
N1 - Accession Number: 106313816. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; systematic review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101163424.
KW - Spine -- Physiology
KW - Workload
KW - Musculoskeletal System -- Pathology
KW - Low Back Pain
KW - Occupational Diseases
KW - Professional Practice, Evidence-Based
KW - Meta Analysis
KW - Quantitative Studies
KW - Odds Ratio
KW - Confidence Intervals
KW - Medline
KW - Research Methodology -- Evaluation
KW - Mathematics
KW - Chi Square Test
KW - Nonexperimental Studies -- Evaluation
KW - Ergonomics
KW - Human
SP - 113
EP - 130
JO - Theoretical Issues in Ergonomics Science
JF - Theoretical Issues in Ergonomics Science
JA - THEOR ISSUES ERGON SCI
VL - 7
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Objective: To critically appraise the observational studies linking cumulative spinal loading and lower back disorders (LBD) among workers engaged in manual material handling and to explore the association between cumulative spinal loading and LBD through a meta-analysis of papers reported in the published literature.Background: Although studies have indicated a definitive relationship between long-term exposure to manual materials handling and LBD, little is generally known about the validity of the cumulative exposure assessment methods used for predicting the risk of LBD.Methods: A comprehensive electronic search on the subject was conducted. The articles found from the search were critically appraised from an epidemiological standpoint. The strengths and weaknesses of the studies were documented. A quantitative assessment was performed for the meta-analysis estimate using the fixed-effect and random-effects (Dersimonian and Laird method) models. The assessments were conducted in two ways: with a standard approach that does not consider study quality and with a modified method that allows weighting scores to be calculated based on the rating of the quality of each study.Results: The electronic search resulted in identification of four epidemiological papers, three of which provided sufficient information for an assessment of epidemiological quality and two of which provided sufficient data to conduct a meta-analysis. The results showed that the methodological quality of the studies ranged from poor to marginal. Without considering the overall study quality for the exposure data, (1) there were substantial differences between the three studies that were rated for epidemiological quality as evidenced by the significant heterogeneity testing at the 10% level and (2) the difference in the mean exposure values between the study and control groups (i.e. summary mean difference) was significant at the 5% level for both the fixed-effect and random-effects models. After accounting for overall study quality, the heterogeneity was reduced but still significant at the 10% level and the summary mean difference was greater than that without the quality score. The meta-odds ratio for LBD outcomes was 1.66 (95% confidence interval using quality scores = 1.46-1.89).Conclusions: The preliminary findings suggest that there likely is an association between cumulative spinal loading and LBD. Further, there are considerable differences among the studies in terms of exposure assessment techniques. A subsequent paper (Part II of this research) provides an in-depth analysis of cumulative spinal loading exposure methods and discusses critical issues related to their reliability and validity for estimating force distribution and practicality for field measurement.
SN - 1463-922X
AD - National Institute for Occupational Safety and Health, MS C24,4676 Columbia Parkway, Cincinnati, OH 45226; trwl@cdc.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106313816&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106313817
T1 - Cumulative spinal loading exposure methods for manual material handling tasks. Part 2: methodological issues and applicability for use in epidemiological studies.
AU - Waters T
AU - Yeung S
AU - Genaidy A
AU - Callaghan J
AU - Barriera-Viruet H
AU - Abdallah S
AU - Kumar S
Y1 - 2006/03//Mar/Apr2006
N1 - Accession Number: 106313817. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; systematic review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101163424.
KW - Spine -- Physiology
KW - Workload Measurement
KW - Occupational Health
KW - Professional Practice, Evidence-Based
KW - Musculoskeletal System -- Pathology
KW - Occupational Diseases
KW - Low Back Pain
KW - Measurement Issues and Assessments
KW - Reliability and Validity
KW - Medline
KW - Biomechanics
KW - Posture
KW - Mathematics
KW - Dose-Response Relationship
KW - Ergonomics
KW - Human
SP - 131
EP - 148
JO - Theoretical Issues in Ergonomics Science
JF - Theoretical Issues in Ergonomics Science
JA - THEOR ISSUES ERGON SCI
VL - 7
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Objective: The goal of this paper is to review and discuss methodological issues related to cumulative spinal loading exposure assessment methods. Background: Research has indicated that there likely is an association between integrated spinal loading and lower back pain. A number of studies have been conducted to evaluate cumulative load; however, comparisons between studies is difficult due to the use of different methods for the assessment of cumulative spinal loading. Methods: A comprehensive electronic search was conducted to locate articles dealing with methods of cumulative spinal loading estimation. The articles were evaluated with respect to methods for obtaining postural data, methods for estimating spinal loads, methods for integrating loads over time and spinal load parameters to be measured. Results: Thirteen articles were located. A summary of the methods used to estimate cumulative spinal load is described and evaluated. Conclusions: There is a pressing need for integrated spinal loading methods that are reliable, valid and practical for use in large occupational epidemiological studies. A number of research needs were outlined aimed at improving the ability to use cumulative load to predict risk of low back disorders due to manual material handling.
SN - 1463-922X
AD - National Institute for Occupational Safety and Health, MS C24, 4676 Columbia Parkway, Cincinnati, OH 45226; trwl@cdc.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106313817&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kang, Hye Na
AU - Han Lee, Sung
AU - Nam Kim, Soon
AU - Man Hong, Choong
AU - Ho Lee, Seok
AU - Hwa Hong, Seung
T1 - A collaborative study to establish a Korea national biological standard for antithrombin concentrate
JO - Thrombosis Research
JF - Thrombosis Research
Y1 - 2006/03//
VL - 117
IS - 5
M3 - Article
SP - 591
EP - 596
SN - 00493848
AB - Abstract: Background and objectives: Six laboratories consisting of three manufacturers and three national control laboratories participated in a collaborative study to evaluate the suitability of a candidate material to serve as the first Korean National Standard for Antithrombin (AT) concentrate. Materials and methods: The potency of this candidate preparation was determined using the heparin cofactor chromogenic method. The method is described in the Minimum Requirements for Biological Products in Korea and in the European Pharmacopoeia. The candidate was calibrated against the second International Standard for AT concentrate, coded as 96/520. Results: The participants contributed data from a total of 90 independent assays and the results were accepted as statistically valid when the outcome of the analysis exhibited linear dose–response relationships and intersected at a common point at zero dose in the slope–ratio model. The combined potency estimates were obtained by taking the geometric means of results from all assays at each laboratory, and overall potency estimates were calculated as unweighted geometric means of results from all laboratories. The results were expressed in the form of histograms with 95% confidence intervals. Conclusions: According to the results of the collaborative study, the candidate preparation showed excellent intra- and inter-laboratory correlations and is judged to be suitable to serve as the Korean National Standard for AT concentrate with the following potency: 51.9 IU/vial (95% confidence intervals=48.24∼55.98 IU/vial). [Copyright &y& Elsevier]
AB - Copyright of Thrombosis Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTITHROMBINS
KW - ANTITHROMBIN III
KW - CHROMOGENIC compounds
KW - KOREA
KW - Antithrombin concentrate
KW - National biological standard
N1 - Accession Number: 19930035; Kang, Hye Na; Email Address: hyena52000@yahoo.co.kr Han Lee, Sung 1 Nam Kim, Soon 1 Man Hong, Choong 1 Ho Lee, Seok 1 Hwa Hong, Seung 1; Affiliation: 1: Biologics Evaluation Department, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Gu, Seoul 122-704, Republic of Korea; Source Info: Mar2006, Vol. 117 Issue 5, p591; Subject Term: ANTITHROMBINS; Subject Term: ANTITHROMBIN III; Subject Term: CHROMOGENIC compounds; Subject Term: KOREA; Author-Supplied Keyword: Antithrombin concentrate; Author-Supplied Keyword: National biological standard; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.thromres.2005.05.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19930035&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jun Zhang
AU - Herman, Eugene H.
AU - Robertson, Donald G.
AU - Reily, Michael D.
AU - Knapton, Alan
AU - Ratajczak, Helen V.
AU - Rifal, Nader
AU - Honchel, Ronald
AU - Blanchard, Kerry T.
AU - Stoll, Raymond E.
AU - Sistare, Frank D.
T1 - Mechanisms and Biomarkers of Cardiovascular Injury Induced by Phosphodiesterase Inhibitor III SK&F 95654 in the Spontaneously Hypertensive Rat.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2006/03//
VL - 34
IS - 2
M3 - Article
SP - 152
EP - 163
SN - 01926233
AB - The cardiovascular injury of the type III selective PDE inhibitor SK&F 95654 was investigated in SHR. Twenty-four hours after a single sc injection of 100 or 200 mg/kg of the drug, rats exhibited cardiomyocyte necrosis and apoptosis, interstitial inflammation, hemorrhage and edema, as well as mesenteric arterial hemorrhage and necrosis, periarteritis, EC and VSMC apoptosis, EC activation, and MC activation and degranulation. Elevated serum levels of cTnT and decreased cTnT immunoperoxidase staining on cardiomyocytes were detected in the drug-treated rats. Serum levels of a 2 -macroglobulin and IL-6 were significantly elevated following drug treatment. NMR spectral patterns of urine samples are significantly different between the drug-treated and control rats. These results indicate that measurement of serum cTnT, acute phase proteins, and cytokines as well as metabonomic urine profiles may serve as potential biomarkers for drug-induced cardiovascular injury in rats. Increased expression of CD63 on MC (tissue biomarker of MC), of nitrotyrosine on MC and EC (an indirect indicator of NO in vivo), and of iNOS on MC and EC (source of NO) suggest that NO produced by activated and degranulated MC as well as activated EC play an important role in SK&F 95654-induced mesenteric vascular injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Apoptosis
KW - Biochemical markers
KW - Cardiovascular system
KW - Heart cells
KW - Inflammation
KW - Hemorrhage
KW - Cardiac troponin T
KW - CD63
KW - endothelial cell activation
KW - endothelial cell activation.
KW - inducible nitric oxide synthase
KW - mast cell degranulation
KW - nitrotyrosine
N1 - Accession Number: 20063355; Jun Zhang 1; Email Address: jun.zhang@fda.hhs.gov; Herman, Eugene H. 1; Robertson, Donald G. 2; Reily, Michael D. 2; Knapton, Alan 1; Ratajczak, Helen V. 3; Rifal, Nader 4; Honchel, Ronald 1; Blanchard, Kerry T. 3; Stoll, Raymond E. 3; Sistare, Frank D. 1; Affiliations: 1: Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA; 2: Metabonomics Evaluation Group, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA; 3: Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877, USA; 4: Department of Laboratory Medicine, Boston Childrens Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA; Issue Info: 2006, Vol. 34 Issue 2, p152; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Apoptosis; Thesaurus Term: Biochemical markers; Subject Term: Cardiovascular system; Subject Term: Heart cells; Subject Term: Inflammation; Subject Term: Hemorrhage; Author-Supplied Keyword: Cardiac troponin T; Author-Supplied Keyword: CD63; Author-Supplied Keyword: endothelial cell activation; Author-Supplied Keyword: endothelial cell activation.; Author-Supplied Keyword: inducible nitric oxide synthase; Author-Supplied Keyword: mast cell degranulation; Author-Supplied Keyword: nitrotyrosine; Number of Pages: 12p; Illustrations: 3 Diagrams, 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/01926230600588562
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Millecchia, Lyndell L.
AU - Willard, Patsy
AU - Robinson, Victor A.
AU - Ramsey, Dawn
AU - McLaurin, Jeffery
AU - Khan, Amir
AU - Brumbaugh, Kurt
AU - Beighley, Christoper M.
AU - Teass, Alexander
AU - Castranova, Vincent
T1 - Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/03//
VL - 90
IS - 1
M3 - Article
SP - 188
EP - 197
PB - Oxford University Press / USA
SN - 10966080
AB - Our laboratory has previously reported results from a rat silica inhalation study which determined that, even after silica exposure ended, pulmonary inflammation and damage progressed with subsequent fibrosis development. In the present study, the relationship between silica exposure, nitric oxide (NO) and reactive oxygen species (ROS) production, and the resultant pulmonary damage is investigated in this model. Rats were exposed to silica (15 mg/m3, 6 h/day) for either 20, 40, or 60 days. A portion of the rats from each exposure were sacrificed at 0 days postexposure, while another portion was maintained without further exposure for 36 days to examine recovery or progression. The major findings of this study are: (1) silica-exposed rat lungs were in a state of oxidative stress, the severity of which increased during the postexposure period, (2) silica-exposed rats had significant increase in lung NO production which increased in magnitude during the postexposure period, and (3) the presence of silica particle(s) in an alveolar macrophage (AM) was highly associated with inducible nitric oxide synthase (iNOS) protein. These data indicate that, even after silica exposure has ended, and despite declining silica lung burden, silica-induced pulmonary NO and ROS production increases, thus producing a more severe oxidative stress. A quantitative association between silica and expression of iNOS protein in AMs was also determined, which adds to our previous observation that iNOS and NO-mediated damage are associated anatomically with silica-induced pathological lesions. Future studies will be needed to determine whether the progressive oxidative stress, and iNOS activation and NO production, is a direct result of silica lung burden or a consequence of silica-induced biochemical mediators. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitric oxide
KW - TOXICOLOGY
KW - Biochemical markers
KW - Rats as laboratory animals
KW - Silica
KW - Oxidative stress
KW - nitric oxide
KW - oxidative stress
KW - rat
KW - reactive oxygen species
KW - silica inhalation
N1 - Accession Number: 20605611; Porter, Dale W. 1; Email Address: DPorter@cdc.gov; Millecchia, Lyndell L. 1; Willard, Patsy 1; Robinson, Victor A. 1; Ramsey, Dawn 2; McLaurin, Jeffery 2; Khan, Amir 2; Brumbaugh, Kurt 1; Beighley, Christoper M. 1; Teass, Alexander 2; Castranova, Vincent 1; Affiliations: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505; 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio 45226; Issue Info: Mar2006, Vol. 90 Issue 1, p188; Thesaurus Term: Nitric oxide; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Biochemical markers; Subject Term: Rats as laboratory animals; Subject Term: Silica; Subject Term: Oxidative stress; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: rat; Author-Supplied Keyword: reactive oxygen species; Author-Supplied Keyword: silica inhalation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfj075
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dnyanmote, Ankur V.
AU - Sawant, Sharmilee P.
AU - Lock, Edward A.
AU - Latendresse, John R.
AU - Warbritton, Alan A.
AU - Mehendale, Harihara M.
T1 - Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-l-cysteine (DCVC): role of nephrogenic tissue repair
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2006/03//
VL - 211
IS - 2
M3 - Article
SP - 133
EP - 147
SN - 0041008X
AB - Abstract: Streptozotocin (STZ)-induced diabetic (DB) rats are protected from nephrotoxicity of gentamicin, cisplatin and mercuric chloride, although the mechanisms remain unclear. Ninety percent of DB mice receiving a LD90 dose (75 mg/kg, ip) of S-1,2-dichlorovinyl-l-cysteine (DCVC) survived in contrast to only 10% of the nondiabetic (NDB) mice surviving the same dose. We tested the hypothesis that the mechanism of protection is upregulated tissue repair. In the NDB mice, DCVC produced steep temporal increases in blood urea nitrogen (BUN) and plasma creatinine, which were associated with proximal tubular cell (PTC) necrosis, acute renal failure (ARF), and death within 48 h. In contrast, in the DB mice, BUN and creatinine increased less steeply, declining after 36 h to completely resolve by 96 h. HPLC analysis of plasma and urine revealed that DB did not alter the toxicokinetics of DCVC. Furthermore, activity of renal cysteine conjugate β-lyase, the enzyme that bioactivates DCVC, was unaltered in DB mice, undermining the possibility of lower bioactivation of DCVC leading to lower injury. [3H]-thymidine pulse labeling and PCNA analysis indicated an early onset and sustained nephrogenic tissue repair in DCVC-treated DB mice. BRDU immunohistochemistry revealed a fourfold increase in the number of cells in S-phase in the DB kidneys even without exposure to DCVC. Blocking the entry of cells into S-phase by antimitotic intervention using colchicine abolished stimulated nephrogenic tissue repair and nephroprotection. These findings suggest that preplacement of S-phase cells in the kidney due to diabetes is critical in mitigating the progression of DCVC-initiated renal injury by upregulation of tissue repair, leading to survival of the DB mice by avoiding acute renal failure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Muridae
KW - Antibacterial agents
KW - Antineoplastic antibiotics
KW - Immunosuppressive agents
KW - 2-dichlorovinyl-L-cysteine ( DCVC )
KW - 3
KW - 3′-diaminobenzidine ( DAB )
KW - 3, 3′-diaminobenzidine ( DAB )
KW - 4-dinitrophenylhydrazine ( DNPH )
KW - acute renal failure ( ARF )
KW - acute tubular necrosis ( ATN )
KW - blood urea nitrogen ( BUN )
KW - bromodeoxyuridine ( BRDU )
KW - colchicine ( CLC )
KW - diabetic ( DB )
KW - distilled water ( DW )
KW - hematoxylin and eosin ( H&E )
KW - Kidney
KW - N-acetyl-DCVC ( DCV-NAC )
KW - nondiabetic ( NDB )
KW - perchloric acid ( PCA )
KW - proliferating cell nuclear antigen assay ( PCNA )
KW - proximal tubular cells ( PTC )
KW - Regeneration
KW - S-1
KW - S-1, 2-dichlorovinyl-L-cysteine ( DCVC )
KW - Streptozotocin
KW - streptozotocin ( STZ )
KW - Type-1 diabetes
N1 - Accession Number: 19765741; Dnyanmote, Ankur V. 1; Sawant, Sharmilee P. 1; Lock, Edward A. 2; Latendresse, John R. 3; Warbritton, Alan A. 3; Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliations: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209-0470, USA; 2: Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA; 3: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 7207, USA; Issue Info: Mar2006, Vol. 211 Issue 2, p133; Thesaurus Term: Muridae; Thesaurus Term: Antibacterial agents; Subject Term: Antineoplastic antibiotics; Subject Term: Immunosuppressive agents; Author-Supplied Keyword: 2-dichlorovinyl-L-cysteine ( DCVC ); Author-Supplied Keyword: 3; Author-Supplied Keyword: 3′-diaminobenzidine ( DAB ); Author-Supplied Keyword: 3, 3′-diaminobenzidine ( DAB ); Author-Supplied Keyword: 4-dinitrophenylhydrazine ( DNPH ); Author-Supplied Keyword: acute renal failure ( ARF ); Author-Supplied Keyword: acute tubular necrosis ( ATN ); Author-Supplied Keyword: blood urea nitrogen ( BUN ); Author-Supplied Keyword: bromodeoxyuridine ( BRDU ); Author-Supplied Keyword: colchicine ( CLC ); Author-Supplied Keyword: diabetic ( DB ); Author-Supplied Keyword: distilled water ( DW ); Author-Supplied Keyword: hematoxylin and eosin ( H&E ); Author-Supplied Keyword: Kidney; Author-Supplied Keyword: N-acetyl-DCVC ( DCV-NAC ); Author-Supplied Keyword: nondiabetic ( NDB ); Author-Supplied Keyword: perchloric acid ( PCA ); Author-Supplied Keyword: proliferating cell nuclear antigen assay ( PCNA ); Author-Supplied Keyword: proximal tubular cells ( PTC ); Author-Supplied Keyword: Regeneration; Author-Supplied Keyword: S-1; Author-Supplied Keyword: S-1, 2-dichlorovinyl-L-cysteine ( DCVC ); Author-Supplied Keyword: Streptozotocin; Author-Supplied Keyword: streptozotocin ( STZ ); Author-Supplied Keyword: Type-1 diabetes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.taap.2005.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=19765741&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weida Tong
AU - Hong Fang
AU - Qian Xie
AU - Huixiao Hong
AU - Leming Shi
AU - Perkins, Roger
AU - Uwe Scherf
AU - Goodsaid, Federico
AU - Frueh, Felix
T1 - Gaining Confidence on Molecular Classification through Consensus Modeling and Validation.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2006/03//Mar/Apr2006
VL - 16
IS - 2/3
M3 - Article
SP - 59
EP - 68
PB - Taylor & Francis Ltd
SN - 15376516
AB - Current advances in genomics, proteomics, and metabonomics would result in a constellation of benefits in human health. Classification applying supervised learning methods to omics data as one of the molecular classification approaches has enjoyed its growing role in clinical application. However, the utility of a molecular classifier will not be fully appreciated unless its quality is carefully validated. A clinical omics data is usually noisy with the number of independent variables far more than the number of subjects and, possibly, with a skewed subject distribution. Given that, the consensus approach holds an advantage over a single classifier. Thus, the focus of this review is mainly placed on how validating a molecular classifier using Decision Forest (DF), a robust consensus approach. We recommended that a molecular classifier has to be assessed with respect to overall prediction accuracy, prediction confidence and chance correlation, which can be readily achieved in DF. The commonalities and differences between external validation and cross-validation are also discussed for perspective use of these methods to validate a DF classifier. In addition, the advantages of using consensus approaches for identification of potential biomarkers are also rationalized. Although specific DF examples are used in this review, the provided rationales and recommendations should be equally applicable to other consensus methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR biology
KW - GENOMICS
KW - DECISION trees
KW - DECISION making
KW - CLASSIFICATION
KW - Consensus Modeling
KW - Cross-Validation
KW - Decision Forest (DF)
KW - Molecular Classification
KW - Validation
N1 - Accession Number: 20063484; Weida Tong 1; Email Address: Wtong@nctr.fda.gov Hong Fang 2 Qian Xie 2 Huixiao Hong 2 Leming Shi 1 Perkins, Roger 2 Uwe Scherf 3 Goodsaid, Federico 4 Frueh, Felix 4; Affiliation: 1: Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, AR, 72079, USA 2: Division of Bioinformatics, Z-Tech Inc., Jefferson, AR, 72079, USA 3: Center for Device and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, 20850, USA 4: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, 20852, USA; Source Info: Mar/Apr2006, Vol. 16 Issue 2/3, p59; Subject Term: MOLECULAR biology; Subject Term: GENOMICS; Subject Term: DECISION trees; Subject Term: DECISION making; Subject Term: CLASSIFICATION; Author-Supplied Keyword: Consensus Modeling; Author-Supplied Keyword: Cross-Validation; Author-Supplied Keyword: Decision Forest (DF); Author-Supplied Keyword: Molecular Classification; Author-Supplied Keyword: Validation; Number of Pages: 10p; Illustrations: 4 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15376520600558259
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Orr, Michael S.
T1 - Toxicogenomics and Cross-Species Biomarker Discovery: Applications in Drug Discovery and Safety Assessment.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2006/03//Mar/Apr2006
VL - 16
IS - 2/3
M3 - Article
SP - 79
EP - 87
PB - Taylor & Francis Ltd
SN - 15376516
AB - Toxicogenomics has evolved into a useful technique for providing greater mechanistic insights into adverse effects that will spur the development of novel approaches for identifying and understanding toxicity issues. The ability to capture a snapshot of the transcriptome at any given time during the development of an adverse phenotype allows unprecedented molecular views into the dynamic physiological changes that are occurring on either time or dose continuum for a toxicology study of interest advancing our basic knowledge of adverse events, and providing the necessary scientific framework for developing new strategies and tools for safety assessment programs. The development of an effective subset of cost effective devices for identifying toxicity earlier in the drug development process will help identify the most promising candidate compounds to move forward leading to a reduction in compound attrition due to toxicity. In addition, there is a need in the pharmaceutical industry to develop safety and efficacy biomarkers that are relevant to multiple species such as rat, dog, and human. Genomics provides an opportunity to discover novel cross-species biomarkers for identifying phenotypes such as liver fibrosis, especially if the biomarkers are tissue specific secreted proteins that can be monitored in the serum. This review includes an example of how databases from multiple species, in this case rat and human tissues, can be utilized to identify candidate cross-species diagnostic markers of hepatitis and fibrosis. This study illustrates a genomic approach for identifying candidate cross-species biomarkers of cirrhosis/fibrosis for humans and rats, and a previously known biomarker of fibrosis (APOA1) and a novel candidate biomarker of fibrosis, FETUB were identified. As more “omic” databases are built, a reservoir of molecular information will become available for toxicologist to gain more extensive views on the physiological alterations induced by adverse events, which will inevitably lead to the development of better tools for predicting, identifying, categorizing, and determining cross-species impact of the toxicity and ultimate provide a novel scientific scaffold for improving safety assessment protocols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC toxicology
KW - BIOCHEMICAL genetics
KW - MEDICAL genetics
KW - TOXICOLOGY
KW - BIOCHEMICAL markers
KW - Cross-Species Biomarkers
KW - Toxicogenomics
N1 - Accession Number: 20063485; Orr, Michael S. 1; Email Address: Michael.Orr@FDA.gov; Affiliation: 1: U.S. Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Silver Spring, MD, 20903-0002, USA; Source Info: Mar/Apr2006, Vol. 16 Issue 2/3, p79; Subject Term: GENETIC toxicology; Subject Term: BIOCHEMICAL genetics; Subject Term: MEDICAL genetics; Subject Term: TOXICOLOGY; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: Cross-Species Biomarkers; Author-Supplied Keyword: Toxicogenomics; Number of Pages: 9p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1080/15376520600558317
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20063485&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shiew-Mei Huang
AU - Goodsaid, Federico
AU - Rahman, Atiqur
AU - Frueh, Felix
AU - Lesko, Lawrence J.
T1 - Application of Pharmacogenomics in Clinical Pharmacology.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2006/03//Mar/Apr2006
VL - 16
IS - 2/3
M3 - Article
SP - 89
EP - 99
PB - Taylor & Francis Ltd
SN - 15376516
AB - Many factors can affect a patient's response to a drug. These include intrinsic factors such as age, gender, race/ethnicity, genetics, disease states, organ dysfunctions, and other physiological changes, including pregnancy, lactation, and extrinsic factors such as smoking, diet (food, juice, dietary supplements), and concomitant medications (ICH E5, 1998 and 2004). The interplay of genotypes of the enzymes, transporters and receptors, among other factors (such as concomitant medications and disease states), can affect the risk/benefit ratio for individual patients. This commentary discusses when the genomic information should be obtained during drug development and when it is to be assimilated into labeling and standards of care that can be used to “individualize” drug therapy and become one of the pillars of “personalized medicine.” [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - PHARMACOLOGY
KW - DRUGS
KW - DRUG development
KW - HUMAN genome
KW - Clinical Pharmacology
KW - Pharmacogenomics Application
N1 - Accession Number: 20063478; Shiew-Mei Huang 1; Email Address: Shiewmei.huang@fda.hhs.gov Goodsaid, Federico 1 Rahman, Atiqur 1 Frueh, Felix 1 Lesko, Lawrence J. 1; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Mar/Apr2006, Vol. 16 Issue 2/3, p89; Subject Term: PHARMACOGENOMICS; Subject Term: PHARMACOLOGY; Subject Term: DRUGS; Subject Term: DRUG development; Subject Term: HUMAN genome; Author-Supplied Keyword: Clinical Pharmacology; Author-Supplied Keyword: Pharmacogenomics Application; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15376520600558333
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mukherjee, Amit
AU - Jackson, Scott A.
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Exploring Genotypic and Phenotypic Diversity of Microbes Using Microarray Approaches.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2006/03//Mar/Apr2006
VL - 16
IS - 2/3
M3 - Article
SP - 121
EP - 128
PB - Taylor & Francis Ltd
SN - 15376516
AB - Application of genome-scale analysis like DNA microarray technology has revolutionized multiple scientific disciplines. Herein, a next generation of DNA microarrays, a DNA tiling approach that allows high throughput sampling of genomes with single-nucleotide precision, is described. As methods revealing a genomic scale examination of cellular phenotypes offer keen insights for genomic analyses, a high throughput system for whole cell phenotyping is similarly detailed. The merit of these technologies in discriminating pathogenic and commensal strains of microbes is emphasized using the microbe, Escherichia coli , as an example. Deployment of microarray strategies to assess closely-related microbial strains should help address diversity of organisms in their feral settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - IMMOBILIZED nucleic acids
KW - ESCHERICHIA coli O157:H7
KW - MICROBIAL diversity
KW - PHENOTYPE
KW - GENETICS
KW - DNA Microarray
KW - DNA Tiling Array
KW - E. coli O157:H7
KW - Microbial Diversity
KW - Phenotypic Microarray
N1 - Accession Number: 20063483; Mukherjee, Amit 1 Jackson, Scott A. 1 LeClerc, J. Eugene 1 Cebula, Thomas A. 1; Email Address: Thomas.Cebula@fda.hhs.gov; Affiliation: 1: Division of Molecular Biology (HFS-025), Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, 20708, USA; Source Info: Mar/Apr2006, Vol. 16 Issue 2/3, p121; Subject Term: DNA microarrays; Subject Term: IMMOBILIZED nucleic acids; Subject Term: ESCHERICHIA coli O157:H7; Subject Term: MICROBIAL diversity; Subject Term: PHENOTYPE; Subject Term: GENETICS; Author-Supplied Keyword: DNA Microarray; Author-Supplied Keyword: DNA Tiling Array; Author-Supplied Keyword: E. coli O157:H7; Author-Supplied Keyword: Microbial Diversity; Author-Supplied Keyword: Phenotypic Microarray; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1080/15376520600558473
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20063483&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choudhuri, Supratim
T1 - Some Major Landmarks in the Path from Nuclein to Human Genome 1.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2006/03//Mar/Apr2006
VL - 16
IS - 2/3
M3 - Article
SP - 137
EP - 159
PB - Taylor & Francis Ltd
SN - 15376516
AB - The completion of sequencing of the human genome as well as the genomes of other species is a spectacular achievement of 20th-century biology. It is appropriately regarded as a turning point in biology and medicine for the 21st century. Knowledge of the human genome will presumably help us understand the genetic instructions that make us human. By learning about the gene sequences, the functional dynamics of the genome as well as the individual genetic differences, scientists hope to understand the molecular basis of the normal state and the diseased state of life on one hand, and develop ways to individualize medicine and nutrition on the other hand. Thus, the science of genomics that has grown out of this genome sequencing effort is expected to revolutionize the future of biology itself. The present article is an attempt to briefly summarize some major landmarks in the path that began with the discovery of “nuclein” and led to the completion of the human genome sequencing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN gene mapping
KW - HUMAN genome
KW - NUCLEIN
KW - GENOMICS
KW - GENETIC research
KW - Genomics
KW - Human Genome Sequencing
KW - Nuclein
N1 - Accession Number: 20063480; Choudhuri, Supratim 1; Email Address: Supratim.Choudhuri@cfsan.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Division of Biotechnology and GRAS Notice Review, Center for Food Safety and Applied Nutrition; Source Info: Mar/Apr2006, Vol. 16 Issue 2/3, p137; Subject Term: HUMAN gene mapping; Subject Term: HUMAN genome; Subject Term: NUCLEIN; Subject Term: GENOMICS; Subject Term: GENETIC research; Author-Supplied Keyword: Genomics; Author-Supplied Keyword: Human Genome Sequencing; Author-Supplied Keyword: Nuclein; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 23p; Document Type: Article
L3 - 10.1080/15376520600558606
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20063480&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gemeniano, Malou
AU - Mpanju, Onesmo
AU - Salomon, Daniel R.
AU - Eiden, Maribeth V.
AU - Wilson, Carolyn A.
T1 - The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein
JO - Virology
JF - Virology
Y1 - 2006/03//
VL - 346
IS - 1
M3 - Article
SP - 108
EP - 117
SN - 00426822
AB - Abstract: Endogenous retroviral genetic material serves as a reservoir for the generation of retroviral pathogens by recombination between activated endogenous or exogenous infectious agents. Some porcine tissues actively express infectious porcine endogenous retroviruses (PERVs). Of the three classes of PERV characterized to date, two, PERV-A and B, are capable of infecting human cells in vitro, whereas PERV-C cannot. Here, we demonstrate that the PERV-C envelope surface protein (SU) when disassociated from its C-terminus binds human cells. Further, we show that PERV-C binding to human cells is not inhibited in 293 cells productively infected with PERV-A, confirming that the molecule PERV-C interacts with on human cells is distinct from that used by PERV-A. Moreover, we demonstrate that the envelope region encompassing the proline-rich region is required for binding to cells in addition to the putative variable region A (VRA) and B (VRB). The region in the C-terminus of the SU that alters the binding and infectivity properties of PERV-C differs by only nine residues from the analogous region of PERV-A. Caution may be warranted even when a xenotransplantation product is from source pigs that do not express human-tropic viruses, as minimal mutations within PERV-C combined with selection in a human recipient could render PERV-C infectious in humans. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRESERVATION of organs, tissues, etc.
KW - ORGANS (Anatomy)
KW - TISSUES
KW - PATHOGENIC microorganisms
KW - ONCOGENIC viruses
KW - RNA viruses
KW - Envelope
KW - Porcine endogenous retrovirus
KW - Receptor binding domain
KW - Virus entry
N1 - Accession Number: 19765788; Gemeniano, Malou 1 Mpanju, Onesmo 1 Salomon, Daniel R. 2 Eiden, Maribeth V. 3 Wilson, Carolyn A. 1; Email Address: wilsonc@cber.fda.gov; Affiliation: 1: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, HFM-725, Building 29B, Room 2NN12, Bethesda, MD 20892, USA 2: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA 3: Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA; Source Info: Mar2006, Vol. 346 Issue 1, p108; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: ORGANS (Anatomy); Subject Term: TISSUES; Subject Term: PATHOGENIC microorganisms; Subject Term: ONCOGENIC viruses; Subject Term: RNA viruses; Author-Supplied Keyword: Envelope; Author-Supplied Keyword: Porcine endogenous retrovirus; Author-Supplied Keyword: Receptor binding domain; Author-Supplied Keyword: Virus entry; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.virol.2005.10.021
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19765788&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Correa-de-Araujo, Rosaly
T1 - Women, gender, and health care disparities
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2006/03//
VL - 16
IS - 2
M3 - Editorial
SP - 40
EP - 40
SN - 10493867
N1 - Accession Number: 20552595; Correa-de-Araujo, Rosaly 1; Email Address: Rcorrea@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Mar2006, Vol. 16 Issue 2, p40; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.whi.2006.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20552595&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Correa-de-Araujo, Rosaly
AU - McDermott, Kelly
AU - Moy, Ernest
T1 - Gender differences across racial and ethnic groups in the quality of care for diabetes
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2006/03//
VL - 16
IS - 2
M3 - Article
SP - 56
EP - 65
SN - 10493867
AB - High-quality care for diabetes is based on proper prevention, coordination of care among a multidisciplinary team of health care professionals, enhanced patient–provider relationships, and patient self-management skills. This paper discusses gender differences across racial and ethnic groups in the quality of care for type 2 diabetes according to 10 measures defined by the National Healthcare Quality Report and the National Healthcare Disparities Report. These measures include 5 process measures and one composite measure derived from the Medical Expenditure Panel Survey and 4 outcome measures derived from the Healthcare Cost and Utilization Project. National rates for 2 process measures—measurement of HbA1c (women 89.70% versus men 90.10%) and lipid profile (women 92.9% versus men 95.3%)—are high, but only 28.9% of women and 33.9% of men with diabetes received all 5 recommended process measures (HbA1c, lipid profile, eye exam, foot exam, and influenza immunization). Screening rates for retinal and foot exams and influenza immunization should be improved for all, but the need is particularly urgent for Hispanics and non-Hispanic blacks. Women and men have similar rates of hospital admissions for uncontrolled diabetes, but rates for lower extremity amputations were higher for men, particularly non-Hispanic blacks and Hispanics. Avoidable hospitalizations for diabetes decreased as income increased across racial/ethnic groups, but other factors (e.g., quality of primary care, age, relationship with providers, patients’ self-management skills) may influence such rates. Moreover, any improvements in the diabetes outcomes measures may lag many years behind any measurable improvements in quality of care. Well-designed interventions that reallocate resources for diabetes self-care should be developed to ensure that gender differences are addressed across racial/ethnic groups. Because much of this care involves the management of risk factors, self-management education should be tailored to the lifestyles and beliefs specific to gender and racial/ethnic groups. [Copyright &y& Elsevier]
AB - Copyright of Women's Health Issues is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Quality control
KW - MINORITIES -- Medical care
KW - DIABETES
KW - SEX differences (Biology)
KW - Diabetes
KW - Disparities in health care
KW - Gender-based research
KW - Men’s health
KW - Social inequalities
KW - Women’s health
N1 - Accession Number: 20552598; Correa-de-Araujo, Rosaly 1; Email Address: Rcorrea@ahrq.gov McDermott, Kelly 2 Moy, Ernest 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: The Medstat Group, Inc, Rockville, Maryland; Source Info: Mar2006, Vol. 16 Issue 2, p56; Subject Term: MEDICAL care -- Quality control; Subject Term: MINORITIES -- Medical care; Subject Term: DIABETES; Subject Term: SEX differences (Biology); Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: Disparities in health care; Author-Supplied Keyword: Gender-based research; Author-Supplied Keyword: Men’s health; Author-Supplied Keyword: Social inequalities; Author-Supplied Keyword: Women’s health; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.whi.2005.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20552598&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kosiak, Beth
AU - Sangl, Judy
AU - Correa-de-Araujo, Rosaly
T1 - Quality of health care for older women: What do we know?
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2006/03//
VL - 16
IS - 2
M3 - Article
SP - 89
EP - 99
SN - 10493867
AB - As the proportion of the population age 65 and over continues to grow—to a projected 20.5% or 77.2 million by the year 2040—tracking the quality, access, and receipt of care for older women becomes more important, since the majority of older citizens are women. This article establishes a rough baseline for the quality of care, primarily preventive care, received by older women compared to older men, using selected measures and data of the 2004 National Healthcare Quality Report and National Healthcare Disparities Report. It highlights significant differences between women and men, as well as differences for racial, ethnic, and educational subgroups. Generally, older non-Hispanic white women frequently score higher than their Hispanic and non-Hispanic black counterparts, and more educated women often score significantly higher than their less-educated peers on several measures of quality of care. Compared to their male counterparts, older women are significantly less likely to have any colorectal screening test, to keep high blood pressure under control, and to receive aspirin or beta-blockers upon hospital admission or discharge for acute myocardial infarction. Results are mixed for the process measures related to diabetes, but improvements are clearly needed toward increased rates of eye and foot examinations. Rates of influenza and pneumococcal vaccinations are low but can be improved through Medicare-covered services. We also found that older women are screened less often for breast cancer than those ages 40 to 64. There is still a pervasive lack of knowledge in the research and clinical communities about the unique health care needs of and appropriate processes of care for older adults. More research needs to focus on the quality of care for this growing population in order to allow the development of geriatric-based quality measures and models of care that will set the standards of healthcare for older adults in general, and older women in particular. [Copyright &y& Elsevier]
AB - Copyright of Women's Health Issues is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTCOME assessment (Medical care)
KW - MEDICAL care -- Quality control
KW - HEALTH disparities
KW - OLDER women -- Health
KW - Aged
KW - Elderly
KW - Gender-based research
KW - Health care quality
KW - Men’s health
KW - Older adults
KW - Women’s health
N1 - Accession Number: 20552601; Kosiak, Beth; Email Address: bkosiak@auanet.org Sangl, Judy 1 Correa-de-Araujo, Rosaly 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Mar2006, Vol. 16 Issue 2, p89; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL care -- Quality control; Subject Term: HEALTH disparities; Subject Term: OLDER women -- Health; Author-Supplied Keyword: Aged; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Gender-based research; Author-Supplied Keyword: Health care quality; Author-Supplied Keyword: Men’s health; Author-Supplied Keyword: Older adults; Author-Supplied Keyword: Women’s health; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.whi.2005.01.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20552601&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106311593
T1 - Introduction: women, gender, and health care disparities.
AU - Correa-de-Araujo R
Y1 - 2006/03//
N1 - Accession Number: 106311593. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Gender Specific Care -- Standards
KW - Quality of Health Care
KW - Women
KW - Women's Health Services -- Standards
KW - United States
SP - 40
EP - 40
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311593&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311594
T1 - Catalyzing quality of care improvements for women.
AU - Correa-de-Araujo R
AU - Clancy CM
Y1 - 2006/03//
N1 - Accession Number: 106311594. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Gender Specific Care -- Standards
KW - Health Care Delivery -- Standards
KW - Quality Assurance -- Administration
KW - Women's Health Services -- Standards
KW - Female
KW - Health Care Delivery -- Administration
KW - United States
KW - Women's Health
KW - Women's Health Services -- Administration
SP - 41
EP - 43
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Rcorrea@ahrq.gov
U2 - PMID: 16638520.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311594&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311596
T1 - Gender differences across racial and ethnic groups in the quality of care for acute myocardial infarction and heart failure associated with comorbidities.
AU - Correa-de-Araujo R
AU - Stevens B
AU - Moy E
AU - Nilasena D
AU - Chesley F
AU - McDermott K
Y1 - 2006/03//
N1 - Accession Number: 106311596. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Gender Specific Care -- Standards
KW - Heart Failure -- Ethnology
KW - Heart Failure -- Therapy
KW - Medicare -- Standards
KW - Myocardial Infarction -- Ethnology
KW - Myocardial Infarction -- Therapy
KW - Quality of Health Care
KW - Women's Health Services -- Standards
KW - Asians
KW - Blacks
KW - Chronic Disease -- Ethnology
KW - Chronic Disease -- Therapy
KW - Comorbidity
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Disease Surveillance
KW - Female
KW - Health Services Accessibility
KW - Health Status Indicators
KW - Hispanics
KW - Male
KW - Odds Ratio
KW - P-Value
KW - Sex Factors
KW - United States
KW - Whites
KW - Human
SP - 44
EP - 55
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Rcorrea@ahrq.gov
U2 - PMID: 16638521.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311596&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311597
T1 - Gender differences across racial and ethnic groups in the quality of care for diabetes.
AU - Correa-de-Araujo R
AU - McDermott K
AU - Moy E
Y1 - 2006/03//
N1 - Accession Number: 106311597. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Diabetes Mellitus, Type 2 -- Ethnology
KW - Diabetes Mellitus, Type 2 -- Therapy
KW - Gender Specific Care -- Standards
KW - Physical Examination -- Utilization
KW - Quality of Health Care
KW - Women's Health Services -- Standards
KW - Asians
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Disease Surveillance
KW - Female
KW - Health Services Accessibility
KW - Health Status Indicators
KW - Hispanics
KW - Male
KW - Odds Ratio
KW - Preventive Health Care -- Standards
KW - Probability Sample
KW - Surveys
KW - United States
KW - Whites
KW - Human
SP - 56
EP - 65
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Rcorrea@ahrq.gov
U2 - PMID: 16638522.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311597&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311599
T1 - Women's health care utilization and expenditures.
AU - Taylor AK
AU - Larson S
AU - Correa-de-Araujo R
Y1 - 2006/03//
N1 - Accession Number: 106311599. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Health Care Costs
KW - Insurance, Health -- Utilization
KW - Medicaid -- Utilization
KW - Patient Compliance -- Ethnology
KW - Preventive Health Care -- Economics
KW - Women's Health Services -- Economics
KW - Women's Health Services -- Utilization
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Asians
KW - Blacks
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Health Services Accessibility -- Economics
KW - Hispanics
KW - Middle Age
KW - Odds Ratio
KW - Preventive Health Care -- Utilization
KW - Quality of Health Care
KW - Surveys
KW - United States
KW - Whites
KW - Human
SP - 66
EP - 79
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. ataylor@ahrq.gov
U2 - PMID: 16638523.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311599&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311601
T1 - Preventive health examinations: a comparison along the rural-urban continuum.
AU - Larson S
AU - Correa-de-Araujo R
Y1 - 2006/03//
N1 - Accession Number: 106311601. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 9101000.
KW - Health Care Costs
KW - Patient Compliance
KW - Physical Examination -- Utilization
KW - Preventive Health Care -- Methods
KW - Rural Health
KW - Urban Health
KW - Women's Health Services -- Economics
KW - Women's Health Services -- Utilization
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Comparative Studies
KW - Dependent Variable
KW - Descriptive Statistics
KW - Female
KW - Gender Specific Care
KW - Health Promotion
KW - Health Services Accessibility
KW - Interviews
KW - Logistic Regression
KW - Middle Age
KW - P-Value
KW - Retrospective Design
KW - Surveys
KW - United States
KW - Funding Source
KW - Human
SP - 80
EP - 88
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Maryland 20850, USA. sharon.larson@samhsa.hhs.gov
U2 - PMID: 16638524.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311601&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106311602
T1 - Quality of health care for older women: what do we know?
AU - Kosiak B
AU - Sangl J
AU - Correa-de-Araujo R
Y1 - 2006/03//
N1 - Accession Number: 106311602. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Gender Specific Care -- Standards
KW - Health Services Accessibility
KW - Health Services for the Aged -- Standards
KW - Preventive Health Care -- Standards
KW - Quality of Health Care
KW - Women's Health Services -- Standards
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Ambulatory Care -- Utilization
KW - Blacks
KW - Descriptive Statistics
KW - Female
KW - Health Services for the Aged -- Utilization
KW - Hispanics
KW - Hospitalization
KW - Male
KW - Middle Age
KW - Preventive Health Care -- Utilization
KW - Surveys
KW - United States
KW - Whites
KW - Women's Health Services -- Utilization
KW - Human
SP - 89
EP - 99
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA. bkosiak@auanet.org
U2 - PMID: 16638525.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311602&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-05677-001
AN - 2006-05677-001
AU - Correa-de-Araujo, Rosaly
AU - Clancy, Carolyn M.
T1 - Catalyzing Quality of Care Improvements for Women.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/03//Mar-Apr, 2006
VL - 16
IS - 2
SP - 41
EP - 43
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Correa-de-Araujo, Rosaly, Women's Health and Gender-Based Research, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-05677-001. PMID: 16638520 Partial author list: First Author & Affiliation: Correa-de-Araujo, Rosaly; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20061106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cardiovascular Disorders; Health Care Delivery; Human Sex Differences; Quality of Care; Racial and Ethnic Differences. Minor Descriptor: Human Females. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). References Available: Y. Page Count: 3. Issue Publication Date: Mar-Apr, 2006.
AB - In this special issue, gender disparities across race and ethnicity are discussed in the management of 2 key chronic conditions and in preventive care. This special issue begins with Correa-de-Araujo et al., (2006) showing that women with acute myocardial infarction or congestive heart failure continue to fare worse than men in the receipt of drug therapy. In a comprehensive overview of women's health care utilization and expenditure, Taylor et al. (2006) show that white women continue to use any type of health services more frequently and use more prescription drugs than minority women and men, but both white and Hispanic women pay a higher proportion of income to out-of-pocket medical care expenses. Quality of care is a priority for women. They are the decision makers for their own health care as well as that of their family members. Factors influencing health disparities are numerous, and many are still unexplored and poorly understood. Moreover, how these factors are related is also poorly understood. Social, economic, educational, and system factors may continue to mask some of the real reasons behind disparities. Worldwide, women's health is a major research and policy priority. Caring for women requires knowledge and experience in a complex mix of general health and wellness, reproductive issues, and specific disease and therapeutic needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender disparities
KW - quality of cafe
KW - women
KW - preventive care
KW - myocardial infarction
KW - congestive heart failure
KW - women's health care
KW - minorities
KW - health disparities
KW - 2006
KW - Cardiovascular Disorders
KW - Health Care Delivery
KW - Human Sex Differences
KW - Quality of Care
KW - Racial and Ethnic Differences
KW - Human Females
KW - 2006
DO - 10.1016/j.whi.2006.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05677-001&site=ehost-live&scope=site
UR - Rcorrea@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05677-002
AN - 2006-05677-002
AU - Correa-de-Araujo, Rosaly
AU - Stevens, Beth
AU - Moy, Ernest
AU - Nilasena, David
AU - Chesley, Francis
AU - McDermott, Kelly
T1 - Gender Differences Across Racial and Ethnic Groups in the Quality of Care for Acute Myocardial Infarction and Heart Failure Associated with Comorbidities.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/03//Mar-Apr, 2006
VL - 16
IS - 2
SP - 44
EP - 55
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Correa-de-Araujo, Rosaly, Women's Health and Gender-Based Research, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-05677-002. PMID: 16638521 Partial author list: First Author & Affiliation: Correa-de-Araujo, Rosaly; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20061106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cardiovascular Disorders; Comorbidity; Human Sex Differences; Quality of Care; Racial and Ethnic Differences. Minor Descriptor: Diabetes; Health Care Delivery; Human Females; Hypertension; Kidney Diseases; Medicare. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Mar-Apr, 2006.
AB - This paper provides important insights on gender differences across racial and ethnic groups in a Medicare population in terms of the quality of care received for acute myocardial infarction (AMI) and congestive heart failure (CHF) in association with diabetes or hypertension/end-stage renal disease (ESRD). Both race/ethnicity and gender are associated with differences in the diagnostic evaluation and treatment of Medicare recipients with these conditions. In the AMI group, non-Hispanic Black and Hispanic patients of both genders were less likely to receive aspirin or β-blockers than non- Hispanic Whites. These differences persisted for Hispanic women and men even when they presented with ESRD or diabetes. Rates for smoking cessation counseling were among the lowest among non-Hispanic Blacks and Hispanics with AMI-diabetes and non-Hispanic blacks with AMI-hypertension/ESRD. Gender comparisons within racial groups for the AMI and AMI-diabetes groups show that among non-Hispanic Whites, women were less likely to receive aspirin and β-blockers. No gender differences were noted among non-Hispanic Black and Hispanic Medicare recipients. In the CHF group, Hispanics were the racial/ethnic group least likely to have an assessment of left ventricular function (LVF), even if they had diabetes and had lower rates of angiotensin-converting enzyme inhibitor therapy or even if they had combined CHF-hypertension/ESRD. Gender comparisons in both the CHF and CHF-hypertension/ESRD groups show that non-Hispanic White women were less likely to have an LVF assessment than non-Hispanic White men. Among all subjects, having comorbidities with AMI was not associated with higher markers of quality cardiovascular care. Closing the many gaps in cardiovascular care must target the specific needs of women and men across racial and ethnic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender differences
KW - racial and ethnic groups
KW - quality of care
KW - acute myocardial infarction
KW - congestive heart failure
KW - comorbidities
KW - Medicare
KW - diabetes
KW - hypertension
KW - end-stage renal disease
KW - 2006
KW - Cardiovascular Disorders
KW - Comorbidity
KW - Human Sex Differences
KW - Quality of Care
KW - Racial and Ethnic Differences
KW - Diabetes
KW - Health Care Delivery
KW - Human Females
KW - Hypertension
KW - Kidney Diseases
KW - Medicare
KW - 2006
DO - 10.1016/j.whi.2005.04.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05677-002&site=ehost-live&scope=site
UR - Rcorrea@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05677-003
AN - 2006-05677-003
AU - Correa-de-Araujo, Rosaly
AU - McDermott, Kelly
AU - Moy, Ernest
T1 - Gender Differences Across Racial and Ethnic Groups in the Quality of Care for Diabetes.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/03//Mar-Apr, 2006
VL - 16
IS - 2
SP - 56
EP - 65
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Correa-de-Araujo, Rosaly, Women's Health and Gender-Based Research, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-05677-003. PMID: 16638522 Partial author list: First Author & Affiliation: Correa-de-Araujo, Rosaly; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20061106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Health Care Delivery; Human Sex Differences; Quality of Care; Racial and Ethnic Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar-Apr, 2006.
AB - High-quality care for diabetes is based on proper prevention, coordination of care among a multidisciplinary team of health care professionals, enhanced patient-provider relationships, and patient self-management skills. This paper discusses gender differences across racial and ethnic groups in the quality of care for type 2 diabetes according to 10 measures defined by the National Healthcare Quality Report and the National Healthcare Disparities Report. These measures include 5 process measures and one composite measure derived from the Medical Expenditure Panel Survey and 4 outcome measures derived from the Healthcare Cost and Utilization Project. National rates for 2 process measures--measurement of HbA1c (women 89.70% versus men 90.10%) and lipid profile (women 92.9% versus men 95.3%)--are high, but only 28.9% of women and 33.9% of men with diabetes received all 5 recommended process measures (HbA1c, lipid profile, eye exam, foot exam, and influenza immunization). Screening rates for retinal and foot exams and influenza immunization should be improved for all, but the need is particularly urgent for Hispanics and non-Hispanic blacks. Women and men have similar rates of hospital admissions for uncontrolled diabetes, but rates for lower extremity amputations were higher for men, particularly non-Hispanic blacks and Hispanics. Avoidable hospitalizations for diabetes decreased as income increased across racial/ethnic groups, but other factors (e.g., quality of primary care, age, relationship with providers, patients' self-management skills) may influence such rates. Moreover, any improvements in the diabetes outcomes measures may lag many years behind any measurable improvements in quality of care. Well-designed interventions that reallocate resources for diabetes self-care should be developed to ensure that gender differences are addressed across racial/ethnic groups. Because much of this care involves the management of risk factors, self-management education should be tailored to the lifestyles and beliefs specific to gender and racial/ethnic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender differences
KW - racial and ethnic groups
KW - quality of care
KW - diabetes
KW - 2006
KW - Diabetes
KW - Health Care Delivery
KW - Human Sex Differences
KW - Quality of Care
KW - Racial and Ethnic Differences
KW - 2006
DO - 10.1016/j.whi.2005.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05677-003&site=ehost-live&scope=site
UR - Rcorrea@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09031-001
AN - 2006-09031-001
AU - Woolery, Myra
AU - Carroll, Ellen
AU - Fenn, Elizabeth
AU - Wieland, Holly
AU - Jarosinski, Paul
AU - Corey, Barbara
AU - Wallen, Gwenyth R.
T1 - A Constipation Assessment Scale for Use in Pediatric Oncology.
JF - Journal of Pediatric Oncology Nursing
JO - Journal of Pediatric Oncology Nursing
JA - J Pediatr Oncol Nurs
Y1 - 2006/03//
VL - 23
IS - 2
SP - 65
EP - 74
CY - US
PB - Sage Publications
SN - 1043-4542
SN - 1532-8457
AD - Woolery, Myra, National Institutes of Health, 9000 Rockville Pike, Bldg 10/RM 7D53, Bethesda, MD, US, 20892-1664
N1 - Accession Number: 2006-09031-001. PMID: 16476780 Partial author list: First Author & Affiliation: Woolery, Myra; Research and Practice Development Service, Nursing and Patient Care Services, National Institutes of Health, Bethesda, MD, US. Release Date: 20070122. Correction Date: 20111114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Constipation; Neoplasms; Quality of Life; Statistical Validity; Test Reliability. Minor Descriptor: Pediatrics; Oncology. Classification: Clinical Psychological Testing (2224); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Constipation Assessment Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2006.
AB - Constipation is prevalent in pediatric oncology patients because of treatment with vinca alkaloids and/or narcotics and lifestyle changes secondary to disease process. Sequelae of constipation include anorexia, nausea, vomiting, abdominal pain, emergency department visits, and a decrease in quality of life. There are no reliable instruments to measure constipation in children. A pilot study (N = 21) evaluating the presence and severity of constipation and the reliability and validity of a modified version of the adult Constipation Assessment Scale (CAS) in children with cancer was conducted. Patients receiving weekly vinca alkaloids and/or narcotics = 2 times per day were recruited. Initial bowel function assessments included standardized nursing and nutrition assessments, history/physical review, and baseline CAS score repeated at I hour to assess test-retest reliability. Subsequent assessments included CAS administered 3 times per week and daily patient bowel diaries. Test-retest reliability was evident (r = .93; P = .000). Acceptable construct validity was indicated by a difference in mean CAS scores (t = 4.4, P <00l). Patients reported difficulty with CAS questions and response selections. Symptoms asked on CAS were often not viewed as a problem. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Constipation Assessment Scale
KW - pediatric oncology
KW - vinca alkaloids
KW - lifestyle changes
KW - narcotics
KW - test reliability
KW - test validity
KW - quality of life
KW - 2006
KW - Constipation
KW - Neoplasms
KW - Quality of Life
KW - Statistical Validity
KW - Test Reliability
KW - Pediatrics
KW - Oncology
KW - 2006
DO - 10.1177/1043454205285874
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09031-001&site=ehost-live&scope=site
UR - mwoolery@cc.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05677-004
AN - 2006-05677-004
AU - Taylor, Amy K.
AU - Larson, Sharon
AU - Correa-de-Araujo, Rosaly
T1 - Women's Health Care Utilization and Expenditures.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/03//Mar-Apr, 2006
VL - 16
IS - 2
SP - 66
EP - 79
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Taylor, Amy K., Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-05677-004. PMID: 16638523 Partial author list: First Author & Affiliation: Taylor, Amy K.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20061106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Utilization; Human Females. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Mar-Apr, 2006.
AB - This study examines women's use and expenditures for medical care in the US. In 2000, 91% of women aged 18 years and older used any form of health care services. Overall, 82% of adult women reported an ambulatory care visit, and 11% had an inpatient hospital stay. Mean expense per person with expenses was $3219 for that year. We examined use and expenditures by sociodemographic characteristics. The most notable findings indicate that women with private insurance and those on Medicaid are more likely to use health services than uninsured women. White women, compared to black and Hispanic women, are more likely to have an ambulatory care visit, buy prescription drugs, and use preventive health care services. In addition, white and Hispanic women pay a higher proportion of medical care expenses out-of-pocket than do black women. Finally, nearly 30% of older women in fair or poor health spent 10% or more of their income on medical care. Preventable disparities in access to and receipt of care are unacceptable. To improve the quality of health care for all women, it is important for policymakers to understand the factors that influence their utilization and expenditures for medical care. Data collection, analysis, and reporting by race, ethnicity, and primary language across federally supported health programs are essential to help identify, understand the causes of, monitor, and eventually eliminate disparities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women
KW - health care utilization
KW - health care expenditures
KW - medical care
KW - sociodemographic characteristics
KW - 2006
KW - Health Care Costs
KW - Health Care Utilization
KW - Human Females
KW - 2006
DO - 10.1016/j.whi.2005.11.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05677-004&site=ehost-live&scope=site
UR - ataylor@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05677-005
AN - 2006-05677-005
AU - Larson, Sharon
AU - Correa-de-Araujo, Rosaly
T1 - Preventive Health Examinations: A Comparison Along the Rural-Urban Continuum.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/03//Mar-Apr, 2006
VL - 16
IS - 2
SP - 80
EP - 88
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Larson, Sharon, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, One Choke Cherry Road, Room 7-1010, Rockville, MD, US, 20850
N1 - Accession Number: 2006-05677-005. PMID: 16638524 Partial author list: First Author & Affiliation: Larson, Sharon; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20061106. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Human Females; Preventive Medicine; Rural Environments; Urban Environments. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar-Apr, 2006.
AB - In this analysis, Medical Expenditure Panel Survey data from 2000 were used to examine differences in reports of preventive health service utilization in 4 types of counties: large metropolitan counties, small metropolitan counties, counties adjacent to metropolitan places, and counties not adjacent to metropolitan areas or with fewer than 10,000 residents. Women from counties with 10,000 or fewer residents and not adjacent to a metropolitan county, classified as rural residents, were less likely to report a number of preventive health examinations during the previous 2 years. Rural women were less likely to obtain blood cholesterol tests, dental exams, and mammograms during the previous 2 years when compared to women from large metropolitan counties. Rural women were more likely to obtain blood pressure checks during the previous year when compared to the metropolitan women. Findings for exams that occurred during the preceding 1- and 2-year periods are reported for blood pressure checks, blood cholesterol checks, physical exams, colon cancer screening, dental exams, breast exams, mammograms, and Pap smears. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventive health examinations
KW - preventive health utilization
KW - metropolitan areas
KW - women
KW - rural areas
KW - 2006
KW - Health Care Utilization
KW - Human Females
KW - Preventive Medicine
KW - Rural Environments
KW - Urban Environments
KW - 2006
DO - 10.1016/j.whi.2006.03.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05677-005&site=ehost-live&scope=site
UR - sharon.larson@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00892-001
AN - 2007-00892-001
AU - Perez, Jon
T1 - Suicide Among Indigenous People: Foreword.
T3 - Suicide Among Indigenous Peoples: The Research
JF - Archives of Suicide Research
JO - Archives of Suicide Research
JA - Arch Suicide Res
Y1 - 2006/03//
VL - 10
IS - 2
SP - 101
EP - 102
CY - United Kingdom
PB - Taylor & Francis
SN - 1381-1118
SN - 1543-6136
AD - Perez, Jon, Division of Behavioral Health, Indian Health Services, 6202 E. Cactus Rd., Scottsdale, AZ, US, 85254
N1 - Accession Number: 2007-00892-001. Partial author list: First Author & Affiliation: Perez, Jon; Division of Behavioral Health, Indian Health Services, Scottsdale, AZ, US. Other Publishers: Springer. Release Date: 20070129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Indigenous Populations; Suicide; Suicide Prevention. Minor Descriptor: American Indians. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 2. Issue Publication Date: Mar, 2006.
AB - Suicide, at its most basic level, is the struggle for hope. Regardless of the important distinctions made to better understand and intervene, suicide is grounded in that struggle, and all of us personally affected by it or professionally involved in its prevention, are so engaged. The various cultures, worldviews, approaches, methodologies, data, analyses, and conclusions presented in this volume support this view. It is, perhaps, the most important unifying precept in a field of study and intervention, particularly among indigenous populations, that otherwise contains significant differences, many of which are complex and a few vexing. The author briefly describes his personal experiences working with a suicide intervention program in Indian Country. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention
KW - indigenous populations
KW - 2006
KW - Indigenous Populations
KW - Suicide
KW - Suicide Prevention
KW - American Indians
KW - 2006
DO - 10.1080/13811110600556590
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00892-001&site=ehost-live&scope=site
UR - Jon.Perez@ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07161-002
AN - 2006-07161-002
AU - Waters, T.
AU - Yeung, S.
AU - Genaidy, A.
AU - Callaghan, J.
AU - Barriera-Viruet, H.
AU - Deddens, J.
T1 - Cumulative spinal loading exposure methods for manual material handling tasks. Part 1: Is cumulative spinal loading associated with lower back disorders?
JF - Theoretical Issues in Ergonomics Science
JO - Theoretical Issues in Ergonomics Science
JA - Theor Issues Ergon
Y1 - 2006/03//Mar-Apr, 2006
VL - 7
IS - 2
SP - 113
EP - 130
CY - United Kingdom
PB - Taylor & Francis
SN - 1463-922X
SN - 1464-536X
AD - Waters, T., National Institute for Occupational Safety and Health, MS C24, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2006-07161-002. Partial author list: First Author & Affiliation: Waters, T.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20061127. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Back Pain; Occupational Exposure; Physical Disorders; Work Load; Working Conditions. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Working Conditions & Industrial Safety (3670). Population: Human (10). Methodology: Meta Analysis. References Available: Y. Page Count: 18. Issue Publication Date: Mar-Apr, 2006.
AB - Objective: To critically appraise the observational studies linking cumulative spinal loading and lower back disorders (LBD) among workers engaged in manual material handling and to explore the association between cumulative spinal loading and LBD through a meta-analysis of papers reported in the published literature. Background: Although studies have indicated a definitive relationship between long-term exposure to manual materials handling and LBD, little is generally known about the validity of the cumulative exposure assessment methods used for predicting the risk of LBD. Methods: A comprehensive electronic search on the subject was conducted. The articles found from the search were critically appraised from an epidemiological standpoint. The strengths and weaknesses of the studies were documented. A quantitative assessment was performed for the meta-analysis estimate using the fixed-effect and random-effects (Dersimonian and Laird method) models. The assessments were conducted in two ways: with a standard approach that does not consider study quality and with a modified method that allows weighting scores to be calculated based on the rating of the quality of each study. Results: The electronic search resulted in identification of four epidemiological papers, three of which provided sufficient information for an assessment of epidemiological quality and two of which provided sufficient data to conduct a meta-analysis. The results showed that the methodological quality of the studies ranged from poor to marginal. Without considering the overall study quality for the exposure data, (1) there were substantial differences between the three studies that were rated for epidemiological quality as evidenced by the significant heterogeneity testing at the 10% level and (2) the difference in the mean exposure values between the study and control groups (i.e. summary mean difference) was significant at the 5% level for both the fixed-effect and random-effects models. After accounting for overall study quality, the heterogeneity was reduced but still significant at the 10% level and the summary mean difference was greater than that without the quality score. The meta-odds ratio for LBD outcomes was 1.66 (95% confidence interval using quality scores=1.46-1.89). Conclusions: The preliminary findings suggest that there likely is an association between cumulative spinal loading and LBD. Further, there are considerable differences among the studies in terms of exposure assessment techniques. A subsequent paper (Part II of this research) provides an in-depth analysis of cumulative spinal loading exposure methods and discusses critical issues related to their reliability and validity for estimating force distribution and practicality for field measurement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cumulative spinal loading exposure
KW - lower back disorders
KW - manual material handling tasks
KW - 2006
KW - Back Pain
KW - Occupational Exposure
KW - Physical Disorders
KW - Work Load
KW - Working Conditions
KW - 2006
DO - 10.1080/14639220500111392
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07161-002&site=ehost-live&scope=site
UR - trwl@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02116-015
AN - 2006-02116-015
AU - Taub, Jennifer
T1 - A sociological approach to understanding first time motherhood: The early months.
JF - Psychology of Women Quarterly
JO - Psychology of Women Quarterly
JA - Psychol Women Q
Y1 - 2006/03//
VL - 30
IS - 1
SP - 120
EP - 120
CY - United Kingdom
PB - Blackwell Publishing
SN - 0361-6843
SN - 1471-6402
N1 - Accession Number: 2006-02116-015. Partial author list: First Author & Affiliation: Taub, Jennifer; Center for Mental Health Services Research, University of Massachusetts Medical School, MA, US. Other Publishers: Sage Publications; Wiley-Blackwell Publishing Ltd. Release Date: 20060612. Correction Date: 20110822. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Feminism; Mothers; Narratives; Sociology. Minor Descriptor: First Experiences; Human Females; Myths. Classification: Sex Roles & Women's Issues (2970). Population: Human (10); Female (40). Reviewed Item: Miller, Tina. Making Sense of Motherhood: A Narrative Approach=New York: Cambridge University Press, 2005. 176 pp., $70.00; $26.99; 2005. Page Count: 1. Issue Publication Date: Mar, 2006.
AB - Reviews the book, Making Sense of Motherhood: A Narrative Approach by Tina Miller (2005). This book presents the first time journey into motherhood from a narrative, qualitative, sociological perspective. The author's work focuses on women's internal sense of self as they move into motherhood. The work is not self-described as feminist, but the author utilizes feminist constructs and research methods. The book implies that women's reliance on medical 'experts' in the pregnancy and birth experience detracts from women's awareness of and connection to their own mothering intuition and capacity. Upon finishing this book, I have taken away two key findings from author's work. The first is that not enough attention is paid within medical settings to the experiences of individual women, be they from minority or majority cultures. The second is that many middle-class women have so embodied the cultural myths of motherhood that it is very hard for them to acknowledge any difficulties they may have in the new mother role. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sociological approach
KW - first time motherhood
KW - feminism
KW - cultural myths
KW - middle class women
KW - 2006
KW - Feminism
KW - Mothers
KW - Narratives
KW - Sociology
KW - First Experiences
KW - Human Females
KW - Myths
KW - 2006
U2 - Miller, Tina. (2005); Making Sense of Motherhood: A Narrative Approach; New York: Cambridge University Press, 2005. 176 pp., $70.00; $26.99; 0-521-83572-0 (Hardcover); 0-521-54364-9 (Paperback).
DO - 10.1111/j.1471-6402.2006.00274.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02116-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00892-007
AN - 2007-00892-007
AU - EchoHawk, Marlene
T1 - Suicide Prevention Efforts in One Area of Indian Health Service, USA.
T3 - Suicide Among Indigenous Peoples: The Research
JF - Archives of Suicide Research
JO - Archives of Suicide Research
JA - Arch Suicide Res
Y1 - 2006/03//
VL - 10
IS - 2
SP - 169
EP - 176
CY - United Kingdom
PB - Taylor & Francis
SN - 1381-1118
SN - 1543-6136
AD - EchoHawk, Marlene, Behavioral Health Program, Indian Health Services, 801 Thompson Avenue, Suite 300, Rockville, MD, US, 20852
N1 - Accession Number: 2007-00892-007. PMID: 16574614 Partial author list: First Author & Affiliation: EchoHawk, Marlene; Indian Health Services, Behavioral Health Program, Rockville, MD, US. Other Publishers: Springer. Release Date: 20070129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Indigenous Populations; Suicide; Suicide Prevention. Minor Descriptor: Alaska Natives; American Indians; Health Care Services. Classification: Behavior Disorders & Antisocial Behavior (3230); Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2006.
AB - Suicide is the second leading cause of death in young Indian people. USA's Indian Health Service is responsible for the health of the people; a structured system and services are provided. These services include surveillance and suicide investigation, to allow for better understanding. This article presents the current epidemiology on suicide for American Indians and Alaskan Natives (AI/AN). The data show a very high rate in the young especially males. Beyond the general, the article offers a unique look into a suicidal AI/AN young person, through the psychological autopsy. A case illustration, E.S., a 16-year-old male who died by suicide, is outlined. Discussion, the author's words, and current efforts of Indian Health Services are presented, but it is concluded that much greater effort is needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention efforts
KW - Indian Health Services
KW - US
KW - epidemiology
KW - American Indians
KW - Alaska Natives
KW - 2006
KW - Epidemiology
KW - Indigenous Populations
KW - Suicide
KW - Suicide Prevention
KW - Alaska Natives
KW - American Indians
KW - Health Care Services
KW - 2006
DO - 10.1080/13811110600558224
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00892-007&site=ehost-live&scope=site
UR - Marlene.Echohawk@ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04387-003
AN - 2006-04387-003
AU - Shelton, Rachel C.
AU - Golin, Carol E.
AU - Smith, Scott R.
AU - Eng, Eugenia
AU - Kaplan, Andrew
T1 - Role of the HIV/AIDS Case Manager: Analysis of a Case Management Adherence Training and Coordination Program in North Carolina.
JF - AIDS Patient Care and STDs
JO - AIDS Patient Care and STDs
JA - AIDS Patient Care STDS
Y1 - 2006/03//
VL - 20
IS - 3
SP - 193
EP - 204
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
SN - 1557-7449
AD - Golin, Carol E., UNC Sheps Center for Health Services Research, 725 Airport Road, Suite 208, CB #7590, Chapel Hill, NC, US, 27599-7590
N1 - Accession Number: 2006-04387-003. PMID: 16548716 Partial author list: First Author & Affiliation: Shelton, Rachel C.; University of North Carolina at Chapel Hill, School of Public Health, Department of Health Behavior and Health Education, Chapel Hill, NC, US. Release Date: 20060925. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Kaplan, Andrew. Major Descriptor: Case Management; Drug Therapy; Health Care Delivery; HIV; Training. Minor Descriptor: Antiviral Drugs; Patients; Professional Development; Treatment Compliance. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Mar, 2006.
AB - Highly active antiretroviral therapy (HAART) adherence rates of 90%-95% or more are required to be effective at treating the virus and preventing drug resistance. From both a medical and public health perspective, it is essential that HIV-positive clients strictly adhere to antiretroviral treatment regimens. One promising approach to promoting optimal adherence rates among HIV-positive individuals is training and reimbursing case managers to provide adherence coordination services to HIV-positive clients. In this study, a sample of 16 HIV/ AIDS case managers from agencies across North Carolina participated in a Case Management Adherence Training and Coordination Program for a 3-month period. After case manager training, case managers enrolled 1-4 of their existing clients, who met eligibility criteria, to receive the adherence coordination program. Data were analyzed from focus group interviews and individual interviews conducted with case manager participants; their respective client care plans were also analyzed to identify primary barriers and strategies reported by case managers. Although case managers perceived themselves to be well positioned to provide adherence coordination services for their HIV-positive clients, they also identified barriers that they face in providing these services, including lack of reimbursement for their time, inadequate training, and insufficient knowledge of HIV/AIDS and medications. The findings of this study suggest that, with appropriate training and reimbursement, HIV/AIDS case managers can play a pivotal role in promoting and improving client adherence to antiretroviral medications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV case manager
KW - case management
KW - training
KW - coordination program
KW - highly active antiretroviral therapy
KW - HIV positive clients
KW - 2006
KW - Case Management
KW - Drug Therapy
KW - Health Care Delivery
KW - HIV
KW - Training
KW - Antiviral Drugs
KW - Patients
KW - Professional Development
KW - Treatment Compliance
KW - 2006
U1 - Sponsor: North Carolina Department of Heath and Human Services. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health. Grant: R01-DA013826; R01- GM06681; R01-GM064803; K24 MH071191. Recipients: Kaplan, Andrew
U1 - Sponsor: National Institute of Mental Health. Grant: K23 MH01862-01. Recipients: Golin, Carol E.
U1 - Sponsor: UNC Center. Grant: P30-AI50410. Other Details: For AIDS Research. Recipients: No recipient indicated
DO - 10.1089/apc.2006.20.193
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04387-003&site=ehost-live&scope=site
UR - Carol_Golin@med.unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02706-009
AN - 2006-02706-009
AU - Snowden, Lonnie
AU - Masland, Mary
AU - Ma, Yifei
AU - Ciemens, Elizabeth
T1 - Strategies to improve minority access to public mental health services in California: Description and preliminary evaluation.
T3 - Addressing mental health disparities through culturally competent research and community-based practice
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2006/03//
VL - 34
IS - 2
SP - 225
EP - 235
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Snowden, Lonnie, Center for Mental Health Services Research, University of California-Berkeley, 120 Haviland Hall, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2006-02706-009. Partial author list: First Author & Affiliation: Snowden, Lonnie; Center for Mental Health Services Research, University of California-Berkeley, Berkeley, CA, US. Release Date: 20060313. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Health Care Utilization; Minority Groups; Treatment Barriers. Minor Descriptor: Evaluation. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Mar, 2006.
AB - The present study documented and evaluated steps taken by public mental health administrators to recruit members of underrepresented ethnic minority populations into treatment. By surveying county-level ethnic program specialists in the decentralized California state system, the study identified strategies considered effective for reaching African American, Asian American, Latino, and Native Americans communities and overcoming barriers to treatment-seeking. In multivariate analysis, strategies were linked to ethnic-specific Medi-Cal penetration rates calculated as measures of access. Results indicated that undertaking outreach activities was associated with greater access for Latinos and Native Americans. For Asian Americans, hiring bilingual or bicultural staff was associated with greater access but having a bilingual or bicultural receptionist was associated with lesser access. For all minority groups as well as for Whites, the overall supply of mental health practitioners in the county was strongly associated with greater access. The study documented real-world efforts to improve minority access and, despite limitations imposed by its cross-sectional design, provided preliminary evidence of effectiveness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - minority group access
KW - public mental health services
KW - evaluation
KW - mental health practitioners
KW - 2006
KW - Community Mental Health Services
KW - Health Care Utilization
KW - Minority Groups
KW - Treatment Barriers
KW - Evaluation
KW - 2006
U1 - Sponsor: California Program of Access to Care, US. Recipients: No recipient indicated
U1 - Sponsor: California Policy Research Center, US. Recipients: No recipient indicated
U1 - Sponsor: University of California, US. Recipients: No recipient indicated
DO - 10.1002/jcop.20092
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02706-009&site=ehost-live&scope=site
UR - Snowden@uclink.berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05490-002
AN - 2006-05490-002
AU - Power, Kathryn
T1 - Editorial.
T3 - The Health Promotion of People with Psychiatric Disabilities
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2006///Spr 2006
VL - 29
IS - 4
SP - 239
EP - 240
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
N1 - Accession Number: 2006-05490-002. PMID: 16689033 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Power, Kathryn; Center For Mental Health Services, SAMHSA, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20060619. Correction Date: 20150824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Dualism; Health; Health Promotion; Mental Disorders; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Spr 2006.
AB - It is only within the past few decades that the mind-body connection has begun to regain widespread acceptance. Former Surgeon General David Satcher said that one of the foremost contributions of contemporary research is the extent to which it has mended the destructive split between 'mental' and 'physical health.' We have to continue to discuss the specific issue of health promotion for people with psychiatric disabilities. This issue is particularly critical because the life expectancy for individuals with serious mental illnesses is about 10 years fewer than the general population. The World Health Organization identified mental illnesses as the leading cause of disability worldwide. The motto of the World Federation on Mental Health is 'there is no health without mental health.' (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mind body connection
KW - mental health
KW - physical health
KW - health promotion
KW - psychiatric disabilities
KW - 2006
KW - Dualism
KW - Health
KW - Health Promotion
KW - Mental Disorders
KW - Mental Health
KW - 2006
DO - 10.2975/29.2006.239.240
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05490-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03069-001
AN - 2006-03069-001
AU - Deveaugh-Geiss, Joseph
AU - March, John
AU - Shapiro, Mark
AU - Andreason, Paul J.
AU - Emslie, Graham
AU - Ford, Lisa M.
AU - Greenhill, Laurence
AU - Murphy, Dianne
AU - Prentice, Ernest
AU - Roberts, Rosemary
AU - Silva, Susan
AU - Swanson, James M.
AU - Van Zwieten-Boot, Barbara
AU - Vitiello, Benedetto
AU - Wagner, Karen Dineen
AU - Mangum, Barry
T1 - Child and Adolescent Psychopharmacology in the New Millennium: A Workshop for Academia, Industry, and Government.
JF - Journal of the American Academy of Child & Adolescent Psychiatry
JO - Journal of the American Academy of Child & Adolescent Psychiatry
JA - J Am Acad Child Adolesc Psychiatry
Y1 - 2006/03//
VL - 45
IS - 3
SP - 261
EP - 270
CY - US
PB - Lippincott Williams & Wilkins
SN - 0890-8567
SN - 1527-5418
AD - Deveaugh-Geiss, Joseph, Duke Clinical Research Institute, P.O. Box 17969, Durham, NC, US, 27715
N1 - Accession Number: 2006-03069-001. PMID: 16540810 Other Journal Title: Journal of the American Academy of Child Psychiatry. Partial author list: First Author & Affiliation: Deveaugh-Geiss, Joseph; Duke Clinical Research Institute, Durham, NC, US. Other Publishers: Elsevier Science. Release Date: 20060410. Correction Date: 20110207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Mental Disorders; Pediatrics; Psychopharmacology. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2006.
AB - Objective: To give academic researchers, government officials, and industry scientists an opportunity to assess the state of pediatric psychopharmacology and identify challenges facing professionals in the field. Method: Increased federal spending and the introduction of pediatric exclusivity led to large increases in pediatric psychopharmacology research in the 1990s. Despite the increase in research, concerns exist about methods and incentives for making new medications available for use in pediatric psychiatric disorders. In recognition of these concerns, the Duke Clinical Research Institute held a roundtable in September 2004. Participants from the National Institutes of Health, regulatory agencies, academia, and the pharmaceutical industry spoke about the effects of government regulations such as the U.S. Food and Drug Administration Modernization Act and the Pediatric Research Equity Act on pediatric research from academic, clinical, and industry perspectives, and bioethical considerations of such research. Conclusions: To ensure development of new drugs for treating psychiatric disorders in children and adolescents, we must address the challenges posed by the regulatory environment governing pediatric psychopharmacology research. Strategies were identified for improving the evidence base for psychopharmacologic interventions in youth before widespread use and for more effectively defining a research agenda for the future. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pediatric psychopharmacology research
KW - pediatric psychiatric disorders
KW - drug therapy
KW - 2006
KW - Drug Therapy
KW - Mental Disorders
KW - Pediatrics
KW - Psychopharmacology
KW - 2006
U1 - Sponsor: Bristol-Myers Squibb. Recipients: No recipient indicated
U1 - Sponsor: GlaxoSmithKline. Recipients: No recipient indicated
U1 - Sponsor: Johnson & Johnson. Recipients: No recipient indicated
DO - 10.1097/01.chi.0000194568.70912.ee
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03069-001&site=ehost-live&scope=site
UR - BRAINSTORMCNS@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05490-008
AN - 2006-05490-008
AU - Cook, Judith A.
AU - Razzano, Lisa A.
AU - Linsk, Nathan
AU - Dancy, Barbara L.
AU - Grey, Dennis D.
AU - Butler, Sarah B.
AU - Mitchell, Christopher G.
AU - Despotes, Joanne
T1 - Changes in service delivery following HIV/AIDS education of medical and mental health service providers: Results of a one-year follow-up.
T3 - The Health Promotion of People with Psychiatric Disabilities
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2006///Spr 2006
VL - 29
IS - 4
SP - 282
EP - 288
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Cook, Judith A., Center on Mental Health Services Research & Policy, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2006-05490-008. PMID: 16689039 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20060619. Correction Date: 20150824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Health Care Delivery; Health Care Services; HIV; Medical Education. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Spr 2006.
AB - This study examined changes in service delivery patterns of health and mental health service providers one year after a training on the fundamentals of HIV/AIDS and mental health. Paired t-tests for 424 training recipients showed significant increases in delivery of HIV-related services, and these remained significant while controlling for additional training, job changes, region (urban, rural, suburban), and provider discipline. Multiple logistic regression analysis revealed a significantly greater likelihood of providing direct services to HIV+ individuals among male providers, those with more years of HIV experience, those in counseling disciplines, and those working in a new job since the training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service delivery
KW - HIV
KW - AIDS
KW - health service providers
KW - medical education
KW - 2006
KW - AIDS
KW - Health Care Delivery
KW - Health Care Services
KW - HIV
KW - Medical Education
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: Cooperative Agreement # IT16 Sm19940. Recipients: No recipient indicated
DO - 10.2975/29.2006.282.288
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05490-008&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05490-009
AN - 2006-05490-009
AU - Razzano, Lisa A.
AU - Cook, Judith A.
AU - Hamilton, Marie M.
AU - Hughes, Tonda L.
AU - Matthews, Alicia K.
T1 - Predictors of mental health services use among lesbian and heterosexual women.
T3 - The Health Promotion of People with Psychiatric Disabilities
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2006///Spr 2006
VL - 29
IS - 4
SP - 289
EP - 298
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Razzano, Lisa A., UIC Center on Mental Health Services Research & Policy, Department Of Psychiatry, 104 South Michigan Ave., Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2006-05490-009. PMID: 16689040 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Razzano, Lisa A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20060619. Correction Date: 20150824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Human Females; Lesbianism; Mental Health Services. Minor Descriptor: Client Attitudes; Heterosexuality; Socioeconomic Status. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Chicago Health and Life Experiences of Women. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Spr 2006.
AB - Studies examining mental health services have identified a series of indicators with demonstrated effects on services access, barriers, and utilization, including gender, race/ethnicity, and socioeconomic status, as well as indicators such as type of insurance, client attitudes toward mental health, and diagnosis. This study identifies predictors of mental health services utilization in a diverse community sample of lesbians and heterosexual women (N = 120). Outcomes for study participants are compared to those found in the services utilization literature, and similarities and differences among lesbians and heterosexual women are examined. Suggestions are offered for identifying new factors in mental health service utilization among groups with diverse sexual orientations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services use
KW - predictors
KW - lesbians
KW - heterosexual women
KW - barriers
KW - gender
KW - race
KW - ethnicity
KW - socioeconomic status
KW - client attitudes
KW - 2006
KW - Health Care Utilization
KW - Human Females
KW - Lesbianism
KW - Mental Health Services
KW - Client Attitudes
KW - Heterosexuality
KW - Socioeconomic Status
KW - 2006
DO - 10.2975/29.2006.289.298
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05490-009&site=ehost-live&scope=site
UR - Razzano@psych.uic.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03714-004
AN - 2006-03714-004
AU - Linkins, Karen W.
AU - Lucca, Anna M.
AU - Housman, Michael
AU - Smith, Shelagh A.
T1 - Use of PASRR Programs to Assess Serious Mental Illness and Service Access in Nursing Homes.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/03//
VL - 57
IS - 3
SP - 325
EP - 332
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Linkins, Karen W., Lewin Group, 3130 Fairview Park Drive, Suite 800, Falls Church, VA, US, 22042
N1 - Accession Number: 2006-03714-004. PMID: 16524989 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Linkins, Karen W.; Lewin Group, Falls Church, VA, US. Release Date: 20060522. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Mental Health Services; Nursing Homes; Screening. Classification: Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2006.
AB - Objective: This study assessed the implementation of state Preadmission Screening and Resident Review (PASRR) programs with respect to identification of serious mental illness among nursing facility applicants and residents and access to mental health services. Methods: A national survey was conducted with representatives from agencies that implement PASRR in all 50 states and the District of Columbia. Also, 44 states sent PASRR data for review. Four states were selected for an in-depth study; six nursing homes per state were selected and one staff member from each facility was interviewed (N=24). Medical records were reviewed for 30 to 40 residents from each facility who met criteria for potentially having a disabling serious mental illness (N=786). Results: Medical records showed that 50 percent of patients at the time of admission and 68 percent of patients at the time of the record review had a psychiatric diagnosis, typically a diagnosis of depressive disorder. At the time of admission, fewer records identified individuals with a serious mental illness (9 to 20 percent) or a primary diagnosis of any psychiatric illness (5 to 12 percent). Many records indicated that in-depth, required PASRR screens were not performed. Ninety percent of the states reported that Medicaid covers only basic psychiatric consultation services, such as medication monitoring, in nursing facilities. Between 30 and 32 percent of national survey respondents also characterized access to facilities that provide mental health services as limited and of variable quality. Although all 24 nursing facilities reported providing psychiatric consultation services, access to other mental health services, such as psychosocial rehabilitation or individual counseling, varied considerably. Conclusions: Nursing facility compliance with administration and documentation of PASRR screens appears problematic. Nevertheless, there do not appear to be excessively high numbers of residents with serious mental illness, suggesting that state PASRR programs may contribute positively to the identification of people with serious mental illness. However, many nursing facility residents have some type of psychiatric illness, and PASRR legislation does not appear to have enhanced their ability to gain access to mental health services beyond standard psychiatric consultation and medication therapy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Preadmission Screening and Resident Review
KW - mental illness
KW - nursing homes
KW - mental health services
KW - 2006
KW - Mental Disorders
KW - Mental Health Services
KW - Nursing Homes
KW - Screening
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 03-M00029-50. Recipients: No recipient indicated
DO - 10.1176/appi.ps.57.3.325
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03714-004&site=ehost-live&scope=site
UR - karen.linkins@lewin.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03330-013
AN - 2006-03330-013
AU - Hammad, Tarek A.
AU - Laughren, Thomas
AU - Racoosin, Judith
T1 - Suicidality in pediatric patients treated with antidepressant drugs.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 2006/03//
VL - 63
IS - 3
SP - 332
EP - 339
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
AD - Laughren, Thomas, Division of Neuropharmacological Drug Products, HFD-120, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2006-03330-013. PMID: 16520440 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Hammad, Tarek A.; Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, US. Release Date: 20060410. Correction Date: 20150817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Psychopharmacologic Drugs Advisory Committee and the Pediatric Advisory Committee meeting, Sep, 2005, Bethesda, MD, US. Conference Note: This study was presented in part at the aforementioned conference. Major Descriptor: Antidepressant Drugs; Attempted Suicide; Drug Therapy; Pediatrics; Suicidal Ideation. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Tests & Measures: Children's Depression Rating Scale, Revised; Hamilton Depression Inventory DOI: 10.1037/t41553-000; Montgomery-Asberg Depression Rating Scale DOI: 10.1037/t04111-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2006.
AB - Context: There has been concern that widely used antidepressant agents might be associated with an increased risk of suicidal ideation and behavior (suicidality) in pediatric patients. Objective: To investigate the relationship between antidepressant drugs and suicidality in pediatric patients participating in randomized, placebo-controlled trials. Data Sources: Data were derived from 23 trials conducted in 9 drug company-supported programs evaluating the effectiveness of antidepressants in pediatric patients and 1 multicenter trial (the Treatment for Adolescents With Depression Study) that evaluated fluoxetine hydrochloride. Study Selection: All placebo-controlled trials submitted to the Food and Drug Administration were eligible for inclusion. Evaluable data were derived from 4582 patients in 24 trials. Sixteen trials studied patients with major depressive disorder, and the remaining 8 studied obsessive-compulsive disorder (n = 4), generalized anxiety disorder (n = 2), attention-deficit/hyperactivity disorder (n = 1), and social anxiety disorder (n = 1). Only 20 trials were included in the risk ratio analysis of suicidality because 4 trials had no events in the drug or placebo groups. Data Extraction: Individual patient data were available for all the trials. Data Synthesis: A meta-analysis was conducted to obtain overall suicidality risk estimates for each drug individually, for selective serotonin reuptake inhibitors in depression trials as a group, and for all evaluable trials combined. There were no completed suicides in any of these trials. The multicenter trial was the only individual trial to show a statistically significant risk ratio (4.62; 95% confidence interval [CI], 1.02-20.92). The overall risk ratio for selective serotonin reuptake inhibitors in depression trials was 1.66 (95% CI, 1.02-2.68) and for all drugs across all indications was 1.95 (95% CI, 1.28-2.98). The overall risk difference for all drugs across all indications was 0.02 (95% CI, 0.01-0.03). Conclusion: Use of antidepressant drugs in pediatric patients is associated with a modestly increased risk of suicidality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pediatric patients
KW - antidepressant drugs
KW - suicidality
KW - placebo
KW - 2006
KW - Antidepressant Drugs
KW - Attempted Suicide
KW - Drug Therapy
KW - Pediatrics
KW - Suicidal Ideation
KW - 2006
DO - 10.1001/archpsyc.63.3.332
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03330-013&site=ehost-live&scope=site
UR - laughren@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03714-008
AN - 2006-03714-008
AU - Blitz, Cynthia L.
AU - Wolff, Nancy
AU - Paap, Kris
T1 - Availability of Behavioral Health Treatment for Women in Prison.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/03//
VL - 57
IS - 3
SP - 356
EP - 360
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Blitz, Cynthia L., Rutgers University, Center for Mental Health Services & Criminal Justice Research, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2006-03714-008. PMID: 16524993 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Blitz, Cynthia L.; Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20060522. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Human Females; Mental Health Services; Prisoners; Prisons. Minor Descriptor: Communities; Drug Abuse; Mental Disorders. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Mar, 2006.
AB - Objectives: This study examined whether women with behavioral health needs are more likely to receive treatment for these problems in prison or in the community and to what extent prison disrupts or establishes involvement in treatment for these women. Methods: Data were collected in August 2004 as part of a population survey of female inmates in the only state correctional facility for women in New Jersey. Results: A total of 908 women were surveyed. Fifty-six percent of the women surveyed reported needing behavioral health treatment before incarceration, but only 62 percent of this group reported receiving such treatment in the community. The rate at which treatment matched need within this population before incarceration varied by type of treatment needed: it was the highest (58 percent) for women who needed treatment for mental health problems, lower (52 percent) for those who needed substance abuse treatment, and lowest (44 percent) for those who needed treatment for comorbid mental health and substance abuse problems. In comparison, the rate of match between need for and receipt of treatment in prison was higher for all three types of behavioral health treatment (78 percent, 57 percent, and 65 percent, respectively). Additionally, the findings suggest that prison did not disrupt the type of behavioral health treatment that inmates had previously received in the community. Conclusions: At least in New Jersey, prison appears to improve access to behavioral health treatment among female inmates. Although this conclusion is consistent with the rehabilitation goals of incarceration, it also suggests that some women may have been able to avoid prison if treatment had been provided in the community, especially for substance-related problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral health treatment
KW - prison women
KW - community
KW - treatment
KW - mental health problems
KW - substance abuse problems
KW - 2006
KW - Drug Rehabilitation
KW - Human Females
KW - Mental Health Services
KW - Prisoners
KW - Prisons
KW - Communities
KW - Drug Abuse
KW - Mental Disorders
KW - 2006
U1 - Sponsor: National Institute of Mental Health. Grant: P-20-MH-66170. Recipients: No recipient indicated
DO - 10.1176/appi.ps.57.3.356
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03714-008&site=ehost-live&scope=site
UR - clblitz@rci.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03714-034
AN - 2006-03714-034
AU - Fisher, William H.
T1 - Review of Better Than Well: American Medicine Meets the American Dream.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/03//
VL - 57
IS - 3
SP - 425
EP - 426
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-03714-034. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Fisher, William H.; Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060522. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Intervention; Medical Psychology; Health Care Policy. Minor Descriptor: Self-Concept. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Elliott, Carl. Better Than Well: American Medicine Meets the American Dream=New York, W. W. Norton, 2003, 357 pages, $24.95; 2003. References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2006.
AB - Reviews the book, Better Than Well: American Medicine Meets the American Dream by Carl Elliott (2003). Elliott traces the history of the prestige of the field of medicine and notes that, in the early 21st century the expansion of medicine's domain has taken a new turn. Whereas once it was the physician's role to define and treat disease, medicine now confronts the additional task of treating individuals' dissatisfaction with their identities- their bodies, moods, behaviors, social lives, and, indeed, 'themselves.' In his thoughtful, far-ranging book the author catalogs a host of situations, both physical and psychological, in which individuals seek medical resolutions to their sense that something about who they are is unacceptable, in some cases asking medicine to make them into something that nature did not, but, at the same time, to make them feel good about who they are. The situations described include 'nose jobs' and other essentially cosmetic interventions, as well as psychopharmacologic efforts to make shy people more gregarious and sad people more cheery. The author also describes individuals whose 'discomfort with self is vastly more profound. This book provides a fascinating glimpse at the demands that society will place on medicine in the coming years. I recommend it to the psychiatric community, to be sure, but also to individuals in health care policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American medicine
KW - American dream
KW - sense of self
KW - cosmetic interventions
KW - medical resolutions
KW - health care policy
KW - 2006
KW - Intervention
KW - Medical Psychology
KW - Health Care Policy
KW - Self-Concept
KW - 2006
U2 - Elliott, Carl. (2003); Better Than Well: American Medicine Meets the American Dream; New York, W. W. Norton, 2003, 357 pages, $24.95
DO - 10.1176/appi.ps.57.3.425-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03714-034&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-02971-008
AN - 2006-02971-008
AU - Stone, Marc
AU - Racoosin, Judith A.
AU - Laughren, Thomas
T1 - 'Risk of Death in Elderly Users of Conventional vs. Atypical Antipsychotic Medications': Comment.
JF - The New England Journal of Medicine
JO - The New England Journal of Medicine
JA - N Engl J Med
Y1 - 2006/03//
VL - 354
IS - 9
SP - 973
EP - 973
CY - US
PB - Massachusetts Medical Society
SN - 0028-4793
SN - 1533-4406
N1 - Accession Number: 2006-02971-008. Other Journal Title: Boston Medical & Surgical Journal. Partial author list: First Author & Affiliation: Stone, Marc; Food and Drug Administration, Silver Spring, MD, US. Release Date: 20060403. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Death and Dying; Geriatric Patients; Mortality Rate; Neuroleptic Drugs; Risk Factors. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 1. Issue Publication Date: Mar, 2006.
AB - Comments on an article by Wang et al. (see record [rid]2005-15594-001[/rid]). Wang et al. attempted to estimate the risk of death from the use of conventional antipsychotic medications. Their adjustment methods reduced the estimate from 1.51 to 1.37, confirming confounding; this adjustment is probably insufficient. The authors were severely constrained in their ability to correct for confounding. Diagnoses obtained or inferred from claims data are variably reliable, and risk factors such as cigarette smoking and alcohol consumption are not included. Although users of conventional antipsychotic agents had poorer prognoses, users of atypical agents were more likely to have been in hospitals or nursing homes, giving more opportunities for diagnoses to be reported. The authors also did not account for differences in severity within diagnostic categories. The ability to remove confounding can be tested by showing how much of the observed mortality within each treatment group can be explained. If the data cannot fully explain within-group mortality, it is likely that substantial confounding remains. Improved methods of estimating mortality could narrow, eliminate, or reverse differences in mortality. Published randomized, controlled trials of conventional antipsychotic medications in patients with dementia have not included data on mortality; such information would be welcome. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conventional antipsychotic medications
KW - risk factors
KW - atypical antipsychotic medications
KW - mortality
KW - elderly patients
KW - risk of death
KW - 2006
KW - Death and Dying
KW - Geriatric Patients
KW - Mortality Rate
KW - Neuroleptic Drugs
KW - Risk Factors
KW - 2006
DO - 10.1056/NEJMp058264
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-02971-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106464993
T1 - Fostering acceptance of human papillomavirus vaccines.
AU - Dekker AH
Y1 - 2006/03/02/2006 Mar Supplement 1
N1 - Accession Number: 106464993. Language: English. Entry Date: 20060630. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; review; tables/charts. Supplement Title: 2006 Mar Supplement 1. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503065.
KW - Papillomavirus Infections -- Prevention and Control
KW - Viral Vaccines
KW - Consumer Attitudes
KW - Physician Attitudes
KW - Health Promotion
KW - Education, Continuing (Credit)
KW - Treatment Outcomes
KW - Papillomaviruses -- Classification
KW - Cervix Neoplasms -- Prevention and Control
KW - Viral Vaccines -- Economics
KW - Health Services Accessibility
KW - Health Education
KW - Parental Attitudes
KW - Child
KW - Adolescence
KW - Adult
KW - Change Theory
SP - S14
EP - 9
JO - JAOA: Journal of the American Osteopathic Association
JF - JAOA: Journal of the American Osteopathic Association
JA - JAOA J AM OSTEOPATH ASSOC
VL - 106
IS - 3
CY - Chicago, IL 60611, Illinois
PB - American Osteopathic Association
AB - Multivalent prophylactic human papillomavirus (HPV) vaccines currently in the late stages of clinical testing are safe, immunogenic, and efficacious; and phase 3 tests of a quadrivalent vaccine show that it is 100% effective at preventing HPV types 16 and 18-associated cervical intraepithelial neoplasia grades 2 and 3, adenocarcinoma in situ, and cervical cancer through 2 years of postvaccination follow-up. These vaccines promise to reduce the burden of HPV-related disease. Realizing the full benefit of these vaccines will require a vaccination program that addresses the needs and concerns of healthcare providers, parents, and young adolescent patients who will be involved in the vaccine decision-making process. Osteopathic physicians, by virtue of their dedication to holistic care, are in an optimal position to play a key role in facilitating acceptance of these vaccines among potential vaccinees and their parents and guardians.
SN - 0098-6151
AD - Associate Director, Phoenix Indian Medical Center, Ambulatory Care and Community Health, 4212 N. 16th St, Phoenix, AZ 85016-5319; Anthony.Dekker@ihs.gov
U2 - PMID: 16729556.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106464993&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Giacoia, George P.
AU - Birenbaum, Debra L.
AU - Sachs, Hari Cheryl
AU - Mattison, Donald R.
T1 - The Newborn Drug Development Initiative.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/03/02/Mar2006 Supplement 3
VL - 117
M3 - Article
SP - S1
EP - S8
SN - 00314005
AB - The Best Pharmaceuticals for Children Act (BPCA; Pub L 107-109) was enacted in January 2002 and will sunset in October 2007. The BPCA established processes for studying off-patent and on-patent drugs that are used in pediatric population. Although some drugs have been successfully developed for the neonate (eg, surfactant, nitric oxide), drug development for the youngest, least mature, and most vulnerable pediatric patients is generally lacking. Most drugs are empirically administered to newborns once efficacy has been demonstrated in adults and usefulness is suspected or demonstrated in the older pediatric population. Unfortunately, this process undermines the ability to perform the appropriate studies necessary to demonstrate a drug's short- and long-term safety and efficacy and establish appropriate dosing in neonates. The Newborn Drug Development Initiative Workshop I (held March 29-30, 2004) specifically addressed scientific, clinical, and ethical concerns in the development of trials of pediatric therapeutic agents for neonates. Implementation of the BPCA for all pediatric populations will foster collaboration among federal agencies and academic institutions on scientific investigation, clinical-study design, and consideration of the weight of evidence and address ethical issues related to the performance of drug studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG laws & regulations
KW - PATENTS
KW - DRUG development
KW - NEWBORN infants -- Care
KW - PEDIATRICS
KW - clinical research/trials
KW - clinical-trial design
KW - neonatology
N1 - Accession Number: 20056883; Giacoia, George P. 1; Email Address: gg65m@nih.gov Birenbaum, Debra L. 2 Sachs, Hari Cheryl 2 Mattison, Donald R. 1; Affiliation: 1: Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 2: Division of Pediatric Drug Development, Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland; Source Info: Mar2006 Supplement 3, Vol. 117, pS1; Subject Term: DRUG laws & regulations; Subject Term: PATENTS; Subject Term: DRUG development; Subject Term: NEWBORN infants -- Care; Subject Term: PEDIATRICS; Author-Supplied Keyword: clinical research/trials; Author-Supplied Keyword: clinical-trial design; Author-Supplied Keyword: neonatology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541199 All Other Legal Services; NAICS/Industry Codes: 541110 Offices of Lawyers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1542/peds.2005-0620B
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20056883&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anand, Kanwaljeet J. S.
AU - Aranda, Jacob V.
AU - Berde, Charles B.
AU - Buckman, ShaAvhrée
AU - Capparelli, Edmund V.
AU - Carlo, Waldemar
AU - Hummel, Patricia
AU - Johnston, C. Celeste
AU - Lantos, John
AU - Tutag-Lehr, Victoria
AU - Lynn, Anne M.
AU - Maxwell, Lynne G.
AU - Oberlander, Tim F.
AU - Raju, Tonse N. K.
AU - Soriano, Sulpicio G.
AU - Taddio, Anna
AU - Walco, Gary A.
T1 - Summary Proceedings From the Neonatal Pain-Control Group.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/03/02/Mar2006 Supplement 3
VL - 117
M3 - Article
SP - S9
EP - S22
SN - 00314005
AB - Recent advances in neurobiology and clinical medicine have established that the fetus and newborn may experience acute, established, and chronic pain. They respond to such noxious stimuli by a series of complex biochemical, physiologic, and behavioral alterations. Studies have concluded that controlling pain experience is beneficial with respect to short-term and perhaps long-term outcomes. Yet, pain-control measures are adopted infrequently because of unresolved scientific issues and lack of appreciation for the need for control of pain and its long-term sequelae during the critical phases of neurologic maturation in the preterm and term newborn. The neonatal pain-control group, as part of the Newborn Drug Development Initiative (NDDI) Workshop I, addressed these concerns. The specific issues addressed were (1) management of pain associated with invasive procedures, (2) provision of sedation and analgesia during mechanical ventilation, and (3) mitigation of pain and stress responses during and after surgery in the newborn infant. The cross-cutting themes addressed within each category included (1) clinical-trial designs, (2) drug prioritization, (3) ethical constraints, (4) gaps in our knowledge, and (5) future research needs. This article provides a summary of the discussions and deliberations. Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005). [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROBIOLOGY
KW - CLINICAL medicine
KW - FETUS
KW - NEWBORN infants
KW - PAIN management
KW - analgesia
KW - anesthesia
KW - neonate
KW - Newborn Drug Development Initiative
KW - pain
N1 - Accession Number: 20056884; Anand, Kanwaljeet J. S. 1; Email Address: anandsunny@uams.edu Aranda, Jacob V. 2 Berde, Charles B. 3 Buckman, ShaAvhrée 4 Capparelli, Edmund V. 5 Carlo, Waldemar 6 Hummel, Patricia 7 Johnston, C. Celeste 8 Lantos, John 9 Tutag-Lehr, Victoria 10 Lynn, Anne M. 11 Maxwell, Lynne G. 12 Oberlander, Tim F. 13 Raju, Tonse N. K. 14 Soriano, Sulpicio G. 15 Taddio, Anna 16 Walco, Gary A. 17; Affiliation: 1: Departments of Pediatrics, Anesthesiology, Neurobiology, and Pharmacology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 2: Department of Pediatrics, Pharmacology, and Pharmaceutical Sciences, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan 3: Division of Pain Medicine, Departments of Anesthesia and Pediatrics, Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts 4: Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 5: Department of Pediatrics, Pediatric Pharmacology Research Unit, University of California, San Diego, La Jolla California 6: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 7: Developmental Follow up Program, Loyola University Medical Center, Maywood, Illinois 8: School of Nursing, McGill University, Montreal, Quebec, Canada 9: Department of Pediatrics, MacLean Center Clinical Medical Ethics, Robert Wood Johnson Clinical Scholars Program, Departments of Pediatrics and Medicine, University of Chicago, Chicago, Illinois 10: Department of Pharmaceutics, Eugene Applebaum School of Pharmacy and Health Sciences, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan 11: Department of Anesthesiology and Pediatrics, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, Washington 12: Department of Anesthesiology, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 13: Division of Developmental Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada 14: Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Rockville, Maryland 15: Department of Anesthesiology, Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts 16: Population Health Sciences, Research Institute and Department of Pharmacy, Hospital for Sick Children, Toronto, Ontario, Canada 17: Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Hackensack University Medical Center, Newark, New Jersey; Source Info: Mar2006 Supplement 3, Vol. 117, pS9; Subject Term: NEUROBIOLOGY; Subject Term: CLINICAL medicine; Subject Term: FETUS; Subject Term: NEWBORN infants; Subject Term: PAIN management; Author-Supplied Keyword: analgesia; Author-Supplied Keyword: anesthesia; Author-Supplied Keyword: neonate; Author-Supplied Keyword: Newborn Drug Development Initiative; Author-Supplied Keyword: pain; Number of Pages: 14p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1542/peds.2005-0620C
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20056884&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Newton, Danforth A.
AU - Rao, K. Murali Krishna
AU - Richard A. Dluhy
AU - Baatz, John E.
T1 - Hemoglobin Is Expressed by Alveolar Epithelial Cells.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/03/03/
VL - 281
IS - 9
M3 - Article
SP - 5668
EP - 5676
SN - 00219258
AB - Hemoglobin gene expression in non-erythroid cells has been previously reported in activated macrophages from adult mice and lens cells, and recent studies indicate that alveolar epithelial cells can be derived from hematopoietic stem cells. Our laboratory has now produced strong evidence that hemoglobin is expressed by alveolar type II (ATII) cells and Clara cells, the primary producers of pulmonary surfactant. ATII cells are also closely involved in innate immunity within the lung and are stem cells that differentiate into alveolar type I cells. Reverse transcriptase-PCR was used to measure the expression of transcripts from the α- and β-globin gene clusters in several human and rodent pulmonary epithelial cells. Surprisingly, the two major globin mRNAs characteristic of adult erythroid precursor cells were clearly expressed in human A549 and H441 cell lines, mouse MLE-15 cells, and primary ATII cells isolated from normal rat and mouse lungs. DNA sequencing verified that these PCR products were indeed the result of specific amplification of globin gene cDNAs. These alveolar epithelial cells also expressed the corresponding hemoglobin protein subunits as determined by Western blotting, and tandem mass spectrometry sequencing was used to verify the presence of both α- and β-globin polypeptides in rat primary ATII cells. The function of hemoglobin expression by cells of the pulmonary epithelium will be determined by future studies, but this novel finding could potentially have important implications for the physiology and pathology of the lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - ANOXEMIA
KW - GENE expression
KW - GENETIC regulation
KW - ALVEOLAR process
KW - EPITHELIUM
KW - HEMATOPOIETIC stem cells
N1 - Accession Number: 20414124; Newton, Danforth A. 1 Rao, K. Murali Krishna 2 Richard A. Dluhy 3 Baatz, John E. 1; Email Address: baatzje@musc.edu; Affiliation: 1: Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 3: Department of Chemistry, University of Georgia, Athens, Georgia 30602; Source Info: 3/3/2006, Vol. 281 Issue 9, p5668; Subject Term: HEMOGLOBIN; Subject Term: ANOXEMIA; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: ALVEOLAR process; Subject Term: EPITHELIUM; Subject Term: HEMATOPOIETIC stem cells; Number of Pages: 9p; Illustrations: 4 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1074/jbc.M509314200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20414124&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gammell, Paul M.
AU - Maruvada, Subha
AU - Harris, Gerald R.
T1 - A Simplified Ultrasonic Time-Delay Spectrometry (TDS) System Employing Digital Processing to Minimize Hardware Requirements.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2006/03/06/
VL - 820
IS - 1
M3 - Article
SP - 692
EP - 699
PB - American Institute of Physics
SN - 0094243X
AB - Time delay spectrometry (TDS) is a swept-frequency technique that has proven useful in several ultrasonic applications. The research systems that have been used depended on features of commercial equipment no longer manufactured; commercial TDS ultrasonic systems are not available. The system described here is easy to replicate with readily available equipment and a digitizer and computer capable of handling audio frequency signals. Two applications are shown to demonstrate the capability of this design. © 2006 American Institute of Physics [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC testing
KW - NONDESTRUCTIVE testing
KW - DIGITAL electronics
KW - SPECTROMETRY
KW - SIGNAL processing
KW - Time Delay Spectrometry
KW - Ultrasonic Instrumentation
N1 - Accession Number: 20064929; Gammell, Paul M. 1 Maruvada, Subha 2 Harris, Gerald R. 2; Affiliation: 1: Gammell Applied technologies, LLC, Exmore, VA, 23350 U.S.A. 2: Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852 U.S.A; Source Info: 2006, Vol. 820 Issue 1, p692; Subject Term: ULTRASONIC testing; Subject Term: NONDESTRUCTIVE testing; Subject Term: DIGITAL electronics; Subject Term: SPECTROMETRY; Subject Term: SIGNAL processing; Author-Supplied Keyword: Time Delay Spectrometry; Author-Supplied Keyword: Ultrasonic Instrumentation; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 8p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1063/1.2184594
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shmulewitz, Dvora
AU - Heath, Simon C.
AU - Blundeip, Maude L.
AU - Han, Zhihua
AU - Sharma, Ratnendra
AU - Salit, Jacqueline
AU - Auerbach, Steven B.
AU - Signorini, Stefano
AU - Breslow, Jan L.
AU - Stoffel, Markus
AU - Friedman, Jeffrey M.
T1 - Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2006/03/07/
VL - 103
IS - 10
M3 - Article
SP - 3502
EP - 3509
SN - 00278424
AB - Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate are the major causes of morbidity and mortality in the developed world and are growing problems in developing countries. To map the causal genes, we conducted a population screen for these conditions on the Pacific Island of Kosrae. Family history and genetic data were used to construct a pedigree for the island. Analysis of the pedigree showed highly significant heritability for the metabolic traits under study. DNA samples from 2,188 participants were genotyped with 405 microsatellite markers with an average intermarker distance of 11 cM. A protocol using ʟɪ, a Markov chain Monte Carlo sampling method, was developed to analyze the Kosraen pedigree for height, a model quantitative trait. Robust quantitative trait loci for height were found on 10q21 and 1p31. This protocol was used to map a set of metabolic traits, including plasma leptin to chromosome region 5q35; systolic blood pressure to 20p12; total cholesterol to 19p13, 12q24, and 16qter; hip circumference to 10q25 and 4q23; body mass index to 18p11 and 20q13; apolipoprotein B to 2p24–25; weight to 18q21; and fasting blood sugar to 1q31–1q43. Several of these same chromosomal regions have been identified in previous studies validating the use of ʟɪ. These studies add information about the genetics of the metabolic syndrome and establish an analytical approach for linkage analysis of complex pedigrees. These results also lay the foundation for whole genome scans with dense sets of SNPs aimed to identifying causal genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY
KW - DIABETES
KW - HYPERTENSION
KW - MICROSATELLITES (Genetics)
KW - GENETICS
KW - KOSRAE (Micronesia)
KW - MICRONESIA
KW - LOKI
KW - quantitative trait locus
KW - Syndrome X
N1 - Accession Number: 21040738; Shmulewitz, Dvora 1 Heath, Simon C. 2 Blundeip, Maude L. 3 Han, Zhihua 4 Sharma, Ratnendra 3 Salit, Jacqueline 3 Auerbach, Steven B. 5 Signorini, Stefano 6 Breslow, Jan L. 7 Stoffel, Markus 8 Friedman, Jeffrey M. 3,8; Email Address: friedj@rockefeller.edu; Affiliation: 1: Departments of Biostatistics and Psychiatry, Columbia University, New York, NY 10032 2: Centre Nationale de Genotypage, 91057 Evry, France 3: Laboratories of Molecular Genetics 4: Department of Biochemistry and Molecular Biology, East Tennessee State University, Johnson City, TN 37614 5: Health Resources and Services Administration, Department of Health and Human Services, New York, NY 11433 6: Department of Laboratory Medicine-Desio Hospital, Milano-Bicocca University, Desio, 20126 Milan, Italy 7: Biochemical Genetics and Metabolism 8: Metaboljc Diseases, The Rockefeller University, New York, NY 10021; Source Info: 3/7/2006, Vol. 103 Issue 10, p3502; Subject Term: OBESITY; Subject Term: DIABETES; Subject Term: HYPERTENSION; Subject Term: MICROSATELLITES (Genetics); Subject Term: GENETICS; Subject Term: KOSRAE (Micronesia); Subject Term: MICRONESIA; Author-Supplied Keyword: LOKI; Author-Supplied Keyword: quantitative trait locus; Author-Supplied Keyword: Syndrome X; Number of Pages: 8p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1073/pnas.0510156103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lindenbach, Brett D.
AU - Meuleman, Philip
AU - Ploss, Alexander
AU - Vanwolleghem, Thomas
AU - Syder, Andrew J.
AU - McKeating, Jane A.
AU - Lanford, Robert E.
AU - Feinstone, Stephen M.
AU - Major, Marian E.
AU - Roels, Geert Leroux
AU - Rice, Charles M.
T1 - Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2006/03/07/
VL - 103
IS - 10
M3 - Article
SP - 3805
EP - 3809
SN - 00278424
AB - Hepatitis C virus (HCV) is a major cause of chronic liver disease, frequently progressing to cirrhosis and increased risk of hepatocellular carcinoma. Current therapies are inadequate and progress in the field has been hampered by the lack of efficient HCV culture systems. By using a recently described HCV genotype 2a infectious clone that replicates and produces infectious virus in cell culture (HCVcc), we report here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts. Importantly, virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV. The improved infectivity of animal-derived HCV correlated with virions of a lower average buoyant density than HCVcc, suggesting that physical association with low-density factors influences viral infectivity. These results greatly extend the utility of the HCVcc genetic system to allow the complete in vitro and in vivo dissection of the HCV life cycle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - LIVER diseases
KW - CIRRHOSIS of the liver
KW - LIVER -- Cancer
KW - CELL culture
KW - CARCINOGENESIS
KW - VIRAL hepatitis
KW - animal model
KW - pathogenesis reverse genetics
KW - viral hepatitis
N1 - Accession Number: 21040789; Lindenbach, Brett D. 1 Meuleman, Philip 2 Ploss, Alexander 1 Vanwolleghem, Thomas 2 Syder, Andrew J. 1 McKeating, Jane A. 3 Lanford, Robert E. 4 Feinstone, Stephen M. 5 Major, Marian E. 5 Roels, Geert Leroux 2 Rice, Charles M. 1; Email Address: ricec@mailrockefeller.edu; Affiliation: 1: Center for the Study of Hepatitis C Laboratory of Virology and Infectious Disease The Rockefeller University 1230 York Avenue New York NY 10021 2: Center for Vaccinology Ghent University and Hospital Building A First Floor De Pintelaan 185 9000 Ghent Belgium 3: Division of Immunity and Infection Institute of Biomedical Research University of Birmingham Medical School Birmingham B15 2TT United Kingdom 4: Department of Virology and Immunology Southwest National Primate Research Center and Southwest Foundation for Biomedical Research 7620 NW Loop 410 San Antonio TX 78245 5: Laboratory of Hepatitis Viruses Division of Viral Products Center for Biologics Evaluation and Research Food and Drug Administration B800 Rockville Pike Bethesda MD 20892; Source Info: 3/7/2006, Vol. 103 Issue 10, p3805; Subject Term: HEPATITIS C virus; Subject Term: LIVER diseases; Subject Term: CIRRHOSIS of the liver; Subject Term: LIVER -- Cancer; Subject Term: CELL culture; Subject Term: CARCINOGENESIS; Subject Term: VIRAL hepatitis; Author-Supplied Keyword: animal model; Author-Supplied Keyword: pathogenesis reverse genetics; Author-Supplied Keyword: viral hepatitis; Number of Pages: 5p; Illustrations: 3 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1073/pnas.0511218103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Callahan, John H.
AU - Shefcheck, Kevin J.
AU - Williams, Tracie L.
AU - Musser, Steven M.
T1 - Detection, Confirmation, and Quantification of Staphylococcal Enterotoxin B in Food Matrixes Using Liquid Chromatography-Mass Spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2006/03/15/
VL - 78
IS - 6
M3 - Article
SP - 1789
EP - 1800
SN - 00032700
AB - Although immunoassay-based methods are sensitive and widely used for measuring protein toxins in food matrixes, there is a need for methods that can directly confirm the molecular identity of the toxin in situations where immunoassay tests yield a positive result. A method has been developed that uses mass spectrometry to identify a protein toxin, staphylococcal enterotoxin B (SEB), in a model food matrix, apple juice. The approach employs ultrafiltration to remove low molecular weight components from the sample, after which the remaining high molecular weight fraction, containing the protein, is digested with trypsin. The tryptic fragments are separated from residual biopolymers and analyzed by liquid chromatography-electrospray mass spectrometry. The background is still sufficiently complex that tandem mass spectrometry (MS/MS) is used to confirm the identity of target peptides. Limits of detection are 80 ng of SEB for MS and 100 ng for full scan MS/MS, using a tryptic fragment as the analytical target. Lower detection limits can be obtained using selected ion monitoring and multiple reaction monitoring. The presence of SEB can be confirmed at concentrations as low as 5 parts-per-billion by increasing the size of the sample to 10 mL. The method is applicable to the detection of SEB in other water-soluble food matrixes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOASSAY
KW - PROTEINS
KW - TOXINS
KW - FOOD
KW - MASS spectrometry
KW - ENTEROTOXINS
KW - DIGESTION
KW - TRYPSIN
KW - WATER
N1 - Accession Number: 20515672; Callahan, John H. 1; Email Address: john.callahan@cfsan.fda.gov Shefcheck, Kevin J. 1 Williams, Tracie L. 1 Musser, Steven M. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740; Source Info: 3/15/2006, Vol. 78 Issue 6, p1789; Subject Term: IMMUNOASSAY; Subject Term: PROTEINS; Subject Term: TOXINS; Subject Term: FOOD; Subject Term: MASS spectrometry; Subject Term: ENTEROTOXINS; Subject Term: DIGESTION; Subject Term: TRYPSIN; Subject Term: WATER; Number of Pages: 12p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - McElroy, Peter D.
AU - Ijaz, Kashet
AU - Navin, Thomas R.
T1 - Reply to Cook.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/03/15/
VL - 42
IS - 6
M3 - Letter
SP - 892
EP - 893
SN - 10584838
AB - A letter to the editor is presented in response to comments made on the article "National Survey to Measure Rates of Liver Injury, Hospitalization, and Death Associated With Rifampin and Pyrazinamide for Latent Tuberculosis Infection," published in the Clinical Infectious Diseases.
KW - WOUNDS & injuries
KW - Letters to the editor
KW - Liver
N1 - Accession Number: 19957762; McElroy, Peter D. 1; Email Address: pgm9@cdc.gov; Ijaz, Kashet 2; Navin, Thomas R. 2; Affiliations: 1: Divisions of HIV/AIDS Prevention, National Center for HIV/STD and TB Prevention, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia.; 2: Divisions of Tuberculosis Elimination, National Center for HIV/STD and TB Prevention, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Atlanta, Georgia.; Issue Info: 3/15/2006, Vol. 42 Issue 6, p892; Thesaurus Term: WOUNDS & injuries; Subject Term: Letters to the editor; Subject Term: Liver; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yu, Hai-ning
AU - Yin, Jun-jie
AU - Shen, Sheng-rong
T1 - Effects of epi-gallocatechin gallate on PC-3 cell cytoplasmic membrane in the presence of Cu2+
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2006/03/15/
VL - 95
IS - 1
M3 - Article
SP - 108
EP - 115
SN - 03088146
AB - Abstract: Catechins, which exist in green tea, are excellent antioxidants and metals enhance their pro-oxidative character. In this study, we investigated damage to the cell cytoplasmic membrane of the androgen-insensitive prostate cancer cell PC-3 from rearrangement of EGCG (epigallocatechin gallate), the main bioactive component of catechins. In a cell culture system containing Cu2+, the generation of free radicals from EGCG rearrangement was measured. Electron microscopy, flow cytometry, gel electrophoresis, and ESR measurements showed that the cytoplasmic membrane of PC-3 cells was disrupted in this culture system and that the death of most cells followed within a few minutes. Hydroxyl radicals, detected in the ESR experiment using the spin trapping method, may cause damage to the cytoplasmic membrane. Analysis of F-12 medium after 6 h, by HPLC, showed small amounts of EGCG when PC-3 cells were absent, and no detectable levels when PC-3 cells were present. In addition to the concentration and order in which EGCG and Cu2+ are added to the culture medium, oxides, polymers, or some compounds integrated with the cytoplasmic membrane of the PC-3 cells themselves may have a key role in damage to the PC-3 cell cytoplasmic membrane. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATECHIN
KW - FREE radicals (Chemistry)
KW - POLYPHENOLS
KW - ELECTROPHORESIS
KW - ELECTRON microscopy
KW - Cu2+
KW - Cytoplasm membrane
KW - Epigallocatechin gallate
KW - Free radicals
KW - Prostate cancer cells
KW - Rearrangement
N1 - Accession Number: 18273886; Yu, Hai-ning 1 Yin, Jun-jie 2 Shen, Sheng-rong 1; Email Address: shrshen@zju.edu.cn; Affiliation: 1: Department of Tea Sciences, Zhejiang University, Hangzhou 310029, PR China 2: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Source Info: Mar2006, Vol. 95 Issue 1, p108; Subject Term: CATECHIN; Subject Term: FREE radicals (Chemistry); Subject Term: POLYPHENOLS; Subject Term: ELECTROPHORESIS; Subject Term: ELECTRON microscopy; Author-Supplied Keyword: Cu2+; Author-Supplied Keyword: Cytoplasm membrane; Author-Supplied Keyword: Epigallocatechin gallate; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Prostate cancer cells; Author-Supplied Keyword: Rearrangement; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.foodchem.2004.12.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yakovenko, Maria L.
AU - Cherkasova, Elena A.
AU - Rezapkin, Gennady V.
AU - Ivanova, Olga E.
AU - Ivanov, Alexander P.
AU - Eremeeva, Tatyana P.
AU - Baykova, Olga Y.
AU - Chumakov, Konstantin M.
AU - Agol, Vadim I.
T1 - Antigenic Evolution of Vaccine-Derived Polioviruses: Changes in Individual Epitopes and Relative Stability of the Overall Immunological Properties.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/03/15/
VL - 80
IS - 6
M3 - Article
SP - 30
EP - 30
SN - 0022538X
AB - The Sabin oral poliovirus vaccine (OPV) readily undergoes changes in antigenic sites upon replication in humans. Here, a set of antigenically altered descendants of the three OPV serotypes (76 isolates) was characterized to determine the driving forces behind these changes and their biological implications. The amino acid residues of OPV derivatives that lie within or close to the known antigenic sites exhibited a marked tendency to be replaced by residues characteristic of homotypic wild polioviruses, and these changes may occur very early in OPV evolution. The specific amino acid alterations nicely correlated with serotype-specific changes in the reactivity of certain individual antigenic sites, as revealed by the recently devised monoclonal antibody-based enzyme-linked immunosorbent assay. In comparison to the original vaccine, small changes, if any, in the neutralizing capacity of human or rabbit sera were observed in highly diverged vaccine polioviruses of three serotypes, in spite of strong alterations of certain epitopes. We propose that the common antigenic alterations in evolving OPV strains largely reflect attempts to eliminate fitness-decreasing mutations acquired either during the original selection of the vaccine or already present in the parental strains. Variability of individual epitopes does not appear to be primarily caused by, or lead to, a significant immune evasion, enhancing only slightly, if at all, the capacity of OPV derivatives to overcome immunity in human populations. This study reveals some important patterns of poliovirus evolution and has obvious implications for the rational design of live viral vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIOVIRUS
KW - VIRAL vaccines
KW - AMINO acids
KW - ANTIGENIC determinants
KW - VIRUS diseases
KW - VACCINES
N1 - Accession Number: 20839341; Yakovenko, Maria L. 1 Cherkasova, Elena A. 1,2 Rezapkin, Gennady V. 2 Ivanova, Olga E. 3 Ivanov, Alexander P. 2 Eremeeva, Tatyana P. 3 Baykova, Olga Y. 3 Chumakov, Konstantin M. 2; Email Address: chumakov@cber.fda.gov Agol, Vadim I. 1,3; Email Address: agol@belozersky.msu.ru; Affiliation: 1: A. N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Moscow 119899, Russia 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852 3: M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow Region 142782, Russia; Source Info: Mar2006, Vol. 80 Issue 6, p30; Subject Term: POLIOVIRUS; Subject Term: VIRAL vaccines; Subject Term: AMINO acids; Subject Term: ANTIGENIC determinants; Subject Term: VIRUS diseases; Subject Term: VACCINES; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.80.6.2621-2630.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sawant, Sharmilee P.
AU - Dnyanmote, Ankur V.
AU - Warbritton, Alan
AU - Latendresse, John R.
AU - Mehendale, Harihara M.
T1 - Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2006/03/15/
VL - 211
IS - 3
M3 - Article
SP - 221
EP - 232
SN - 0041008X
AB - Abstract: Previously, we reported high hepatotoxic sensitivity of type 2 diabetic (DB) rats to three dissimilar hepatotoxicants. Additional work revealed that a normally nonlethal dose of CCl4 was lethal in DB rats due to inhibited compensatory tissue repair. The present study was conducted to investigate the importance of compensatory tissue repair in determining the final outcome of hepatotoxicity in diabetes, using another structurally and mechanistically dissimilar hepatotoxicant, thioacetamide (TA), to initiate liver injury. A normally nonlethal dose of TA (300 mg/kg, ip), caused 100% mortality in DB rats. Time course studies (0 to 96 h) showed that in the non-DB rats, liver injury initiated by TA as assessed by plasma alanine or aspartate aminotransferase and hepatic necrosis progressed up to 48 h and regressed to normal at 96 h resulting in 100% survival. In the DB rats, liver injury rapidly progressed resulting in progressively deteriorating liver due to rapidly expanding injury, hepatic failure, and 100% mortality between 24 and 48 h post-TA treatment. Covalent binding of 14C-TA-derived radiolabel to liver tissue did not differ from that observed in the non-DB rats, indicating similar bioactivation-based initiation of hepatotoxicity. S-phase DNA synthesis measured by [3H]-thymidine incorporation, and advancement of cells through the cell division cycle measured by PCNA immunohistochemistry, were substantially inhibited in the DB rats compared to the non-DB rats challenged with TA. Thus, inhibited cell division and compromised tissue repair in the DB rats resulted in progressive expansion of liver injury culminating in mortality. In conclusion, it appears that similar to type 1 diabetes, type 2 diabetes also increases sensitivity to dissimilar hepatotoxicants due to inhibited compensatory tissue repair, suggesting that sensitivity to hepatotoxicity in diabetes occurs in the absence as well as presence of insulin. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Non-insulin-dependent diabetes
KW - Carbohydrate intolerance
KW - Hepatotoxicology
KW - Cell proliferation
KW - CCl4
KW - Liver injury
KW - Thioacetamide
KW - Tissue repair
KW - Type 2 diabetes
N1 - Accession Number: 20180456; Sawant, Sharmilee P. 1; Dnyanmote, Ankur V. 1; Warbritton, Alan 2; Latendresse, John R. 2; Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliations: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Sugar Hall # 306, Monroe, LA 71209-0470, USA; 2: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Mar2006, Vol. 211 Issue 3, p221; Subject Term: Non-insulin-dependent diabetes; Subject Term: Carbohydrate intolerance; Subject Term: Hepatotoxicology; Subject Term: Cell proliferation; Author-Supplied Keyword: CCl4; Author-Supplied Keyword: Liver injury; Author-Supplied Keyword: Thioacetamide; Author-Supplied Keyword: Tissue repair; Author-Supplied Keyword: Type 2 diabetes; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.taap.2005.07.019
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martella, V.
AU - Ciarlet, M.
AU - Bányai, K.
AU - Lorusso, E.
AU - Cavalli, A.
AU - Corrente, M.
AU - Elia, G.
AU - Arista, S.
AU - Camero, M.
AU - Desario, C.
AU - Decaro, N.
AU - Lavazza, A.
AU - Buonavoglia, C.
T1 - Identification of a novel VP4 genotype carried by a serotype G5 porcine rotavirus strain
JO - Virology
JF - Virology
Y1 - 2006/03/15/
VL - 346
IS - 2
M3 - Article
SP - 301
EP - 311
SN - 00426822
AB - Abstract: Rotavirus genome segment 4, encoding the spike outer capsid VP4 protein, of a porcine rotavirus (PoRV) strain, 134/04-15, identified in Italy was sequenced, and the predicted amino acid (aa) sequence was compared to those of all known VP4 (P) genotypes. The aa sequence of the full-length VP4 protein of the PoRV strain 134/04-15 showed aa identity values ranging from 59.7% (bovine strain KK3, P8[11]) to 86.09% (porcine strain A46, P[13]) with those of the remaining 25 P genotypes. Moreover, aa sequence analysis of the corresponding VP8* trypsin cleavage fragment revealed that the PoRV strain 134/04-15 shared low identity, ranging from 37.52% (bovine strain 993/83, P[17]) to 73.6% (porcine strain MDR-13, P[13]), with those of the remaining 25 P genotypes. Phylogenetic relationships showed that the VP4 of the PoRV strain 134/04-15 shares a common evolutionary origin with porcine P[13] and lapine P[22] rotavirus strains. Additional sequence analyses of the VP7, VP6, and NSP4 genes of the PoRV strain 134/04-15 revealed the highest VP7 aa identity (95.9%) to G5 porcine strains, a porcine-like VP6 within VP6 genogroup I, and a Wa-like (genotype B) NSP4, respectively. Altogether, these results indicate that the PoRV strain 134/04-15 should be considered as prototype of a new VP4 genotype, P[26], and provide further evidence for the vast genetic and antigenic diversity of group A rotaviruses. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - ROTAVIRUS diseases
KW - VIRAL replication
KW - AMINO acids
KW - GENETICS
KW - SCISSION (Chemistry)
KW - Diarrhea
KW - Genetic diversity
KW - P genotype
KW - Pigs
KW - Rotavirus
KW - VP4
N1 - Accession Number: 20027768; Martella, V. 1; Email Address: v.martella@veterinaria.uniba.it Ciarlet, M. 2 Bányai, K. 3 Lorusso, E. 1 Cavalli, A. 1 Corrente, M. 1 Elia, G. 1 Arista, S. 4 Camero, M. 1 Desario, C. 1 Decaro, N. 1 Lavazza, A. 5 Buonavoglia, C. 1; Affiliation: 1: Department of Animal Health and Well-being, University of Bari, Valenzano, Bari, Italy 2: Biologics–Clinical Research, Merck and Co., Inc., Blue Bell, PA 19422, USA 3: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 4: Department of Hygiene and Microbiology, University of Palermo, Palermo, Italy 5: Istituto Zooprofilattico Sperimentale di Lombardia/Emilia Romagna, Brescia, Italy; Source Info: Mar2006, Vol. 346 Issue 2, p301; Subject Term: ROTAVIRUSES; Subject Term: ROTAVIRUS diseases; Subject Term: VIRAL replication; Subject Term: AMINO acids; Subject Term: GENETICS; Subject Term: SCISSION (Chemistry); Author-Supplied Keyword: Diarrhea; Author-Supplied Keyword: Genetic diversity; Author-Supplied Keyword: P genotype; Author-Supplied Keyword: Pigs; Author-Supplied Keyword: Rotavirus; Author-Supplied Keyword: VP4; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.virol.2005.11.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shaddock, Joseph G.
AU - Dobrovolsky, Vasily N.
AU - Mittelstaedt, Roberta A.
AU - Heflich, Robert H.
AU - Parsons, Barbara L.
T1 - Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2006/03/20/
VL - 595
IS - 1/2
M3 - Article
SP - 69
EP - 79
SN - 00275107
AB - Abstract: Deficiencies in DNA mismatch repair (MMR) result in predisposition to neoplasia in both rodents and humans. Pms2 is one of the several proteins involved in the eukaryotic MMR system. In order to determine the effect of Pms2-deficiency on mutation, we measured mutant frequencies in the endogenous Hprt gene of lymphocytes from male Pms2 −/− , Pms2 +/− , and Pms2 +/+ mice. Spleens were removed from mice of various ages and lymphocytes isolated from spleens were cultured to determine the frequency of 6-thioguanine-resistant mutants. Mean mutant frequencies in Pms2 −/− mice at 6, 10, 18, and 34 weeks of age [42.6×10−6 (n =6), 38.5×10−6 (n =6), 58.2×10−6 (n =9), and 49.1×10−6 (n =5), respectively] were significantly higher than those of comparably aged Pms2 +/+ and Pms2 +/− mice (all less than 3×10−6). Mutant clones from the mice were expanded, RNA extracted, and Hprt cDNA amplified by RT-PCR. DNA sequencing analysis of 221 mutant cDNAs from the three different Pms2 genotypes identified 182 clones with independent mutations, including five clones that contained multiple mutations. When compared to the mutational spectrum observed in Pms2 +/+ and Pms2 +/− mice, the mutational spectrum for Pms2 −/− mice was significantly different. The Pms2 −/− mutational analysis indicated that loss of the Pms2 protein causes increases in the frequencies of strand-slippage-type frameshift mutations and of A:T→G:C transitions in the Hprt gene. The absolute frequencies of A:T→G:C transitions in MMR-deficient mice suggest increases in this mutation may be a common feature of MMR-deficient mice, not just of Pms2-deficient mice, and may be related to the cancer predisposition that results from loss of MMR function. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOCYTES
KW - MUTATION (Biology)
KW - LESCH-Nyhan syndrome
KW - MICE
KW - RESEARCH
KW - PMS genes
KW - 6-thioguanine-resistant ( TGr )
KW - basepair(s) ( bp )
KW - concanavalin A ( ConA )
KW - DNA mismatch repair ( MMR )
KW - hereditary non-polyposis colon cancer ( HNPCC )
KW - Hprt
KW - hypoxanthine guanine phosphoribosyltransferase (gene) ( Hprt )
KW - intraperitoneal ( i.p. )
KW - Mismatch repair
KW - Mutation
KW - Pms2
N1 - Accession Number: 19849575; Shaddock, Joseph G. 1 Dobrovolsky, Vasily N. 1 Mittelstaedt, Roberta A. 1 Heflich, Robert H. 1 Parsons, Barbara L.; Email Address: bparsons@nctr.fda.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, United States; Source Info: Mar2006, Vol. 595 Issue 1/2, p69; Subject Term: LYMPHOCYTES; Subject Term: MUTATION (Biology); Subject Term: LESCH-Nyhan syndrome; Subject Term: MICE; Subject Term: RESEARCH; Subject Term: PMS genes; Author-Supplied Keyword: 6-thioguanine-resistant ( TGr ); Author-Supplied Keyword: basepair(s) ( bp ); Author-Supplied Keyword: concanavalin A ( ConA ); Author-Supplied Keyword: DNA mismatch repair ( MMR ); Author-Supplied Keyword: hereditary non-polyposis colon cancer ( HNPCC ); Author-Supplied Keyword: Hprt; Author-Supplied Keyword: hypoxanthine guanine phosphoribosyltransferase (gene) ( Hprt ); Author-Supplied Keyword: intraperitoneal ( i.p. ); Author-Supplied Keyword: Mismatch repair; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: Pms2; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2005.10.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubin, Steven
AU - Mauldin, Jeremy
AU - Chumakov, Konstantin
AU - Vanderzanden, Jackie
AU - Iskow, Rebecca
AU - Carbone, Kathryn
T1 - Serological and phylogenetic evidence of monotypic immune responses to different mumps virus strains
JO - Vaccine
JF - Vaccine
Y1 - 2006/03/24/
VL - 24
IS - 14
M3 - Article
SP - 2662
EP - 2668
SN - 0264410X
AB - Abstract: The recent resurgence of mumps epidemics in many countries with ongoing vaccination programs along with evidence of antigenic diversity among mumps virus strains have recently challenged the assumption that mumps virus is serologically monotypic. To address this controversy, we sought to identify two mumps virus strains that would best represent different serotypes, should multiple serotypes exist, and assess the ability of human sera to neutralize both strains. The virus strains, Enders and Lo1, were selected based upon a phylogenetic analysis of the major target of neutralizing antibody, the viral hemagglutinin-neuraminidase (HN) protein, along with data reported by others indicating that (1) these viruses are antigenically distinct and (2) genotypically similar strains have been implicated in cases of reinfection. Our results show that of sera capable of neutralizing one of the virus strains, 90% could neutralize the other, although significant differences in neutralization titers were noted. Though the latter confirms the existence of inter-strain antigenic variability, the fact that few sera were unable to neutralize both virus strains argues against the presence of multiple serotypes. Of those sera incapable of co-neutralization, all but one had low neutralization titers (1:8), suggesting that individuals possessing low levels of neutralizing antibody may be at risk for breakthrough infections, thereby providing an explanation for cases of infection in previously infected or vaccinated individuals. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Immune response
KW - Blood plasma
KW - Preventive medicine
KW - Antibody
KW - Efficacy
KW - Mumps virus
KW - Neutralization
KW - Protection
KW - Vaccine
N1 - Accession Number: 19915942; Rubin, Steven; Email Address: rubins@cber.fda.gov; Mauldin, Jeremy 1; Chumakov, Konstantin 1; Vanderzanden, Jackie 1; Iskow, Rebecca 1; Carbone, Kathryn 1; Affiliations: 1: Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Issue Info: Mar2006, Vol. 24 Issue 14, p2662; Thesaurus Term: Vaccination; Thesaurus Term: Immune response; Subject Term: Blood plasma; Subject Term: Preventive medicine; Author-Supplied Keyword: Antibody; Author-Supplied Keyword: Efficacy; Author-Supplied Keyword: Mumps virus; Author-Supplied Keyword: Neutralization; Author-Supplied Keyword: Protection; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.10.050
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Woo, Emily Jane
AU - Miller, Nancy B.
AU - Ball, Robert
T1 - Adverse events after hepatitis A B combination vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2006/03/24/
VL - 24
IS - 14
M3 - Article
SP - 2685
EP - 2691
SN - 0264410X
AB - Abstract: In May 2001, the U.S. Food and Drug Administration (FDA) approved Hepatitis A Inactivated and Hepatitis B Recombinant Vaccine (HEPAB) for immunization of adults. From May 2001 to September 2003, the Vaccine Adverse Event Reporting System (VAERS) received 305 reports of adverse events after HEPAB. Many events were similar to those reported after the monovalent hepatitis A and B vaccines. Non-serious events included constitutional symptoms and local reactions. Serious events included neurologic, hepatobiliary, and dermatologic conditions, and detailed medical and epidemiological review did not suggest a clear pattern of evidence supporting a causal relationship with the vaccine, except for injection site reactions and some allergic reactions. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Liver diseases
KW - Viral hepatitis
KW - United States
KW - Adverse event
KW - Hepatitis A
KW - Hepatitis B
KW - Twinrix®
N1 - Accession Number: 19915945; Woo, Emily Jane; Email Address: wooj@cber.fda.gov; Miller, Nancy B. 1; Ball, Robert 1; Affiliations: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA; Issue Info: Mar2006, Vol. 24 Issue 14, p2685; Thesaurus Term: Vaccination; Subject Term: Liver diseases; Subject Term: Viral hepatitis; Subject: United States; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Hepatitis A; Author-Supplied Keyword: Hepatitis B; Author-Supplied Keyword: Twinrix®; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2005.10.049
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gieseker, C.M.
AU - Serfling, S.G.
AU - Reimschuessel, R.
T1 - Formalin treatment to reduce mortality associated with Saprolegnia parasitica in rainbow trout, Oncorhynchus mykiss
JO - Aquaculture
JF - Aquaculture
Y1 - 2006/03/31/
VL - 253
IS - 1-4
M3 - Article
SP - 120
EP - 129
SN - 00448486
AB - Abstract: Formalin has been used to treat fish egg fungal infections, but its ability to reduce mortality in fish with fungal infections has not been clearly demonstrated. An experimental infection was induced with abrasion, exposure, and temperature stress to evaluate the ability of formalin to reduce mortalities in rainbow trout (Oncorhynchus mykiss) infected with Saprolegnia parasitica (ATCC 22284). The trout were anesthetized and abraded with a controlled abrasion technique. Temperature stress was performed concurrently with the fungal exposure by moving the trout from an acclimation temperature (15±2 °C) to a higher exposure temperature (22±2 °C) as they were immersed in an exposure tank inoculated with S. parasitica for 4 h. After the exposure, the fish were randomly distributed into 16 experimental tanks (3 fish/tank). Four treatment doses (0, 50, 100, and 150 ppm formalin solution) were evaluated. Fish were given three treatments of 1 h duration: on day 1, 1 h after the fungal exposure, and then the morning of days 3 and 5. The infection rate was 100% for all of the four trials in the study. The average percent mortality from the four trials was 67 (0 ppm), 35 (50 ppm), 29 (100 ppm), and 40 (150 ppm). Statistical analysis of the percent mortality at days 5 and 19 showed that the 50-, 100-, and 150-ppm doses were all significantly different from the 0-ppm dose on both days. [Copyright &y& Elsevier]
AB - Copyright of Aquaculture is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAINBOW trout
KW - DEATH (Biology)
KW - FISHES
KW - FORMALDEHYDE
KW - Control
KW - Formalin
KW - Saprolegnia
N1 - Accession Number: 20183687; Gieseker, C.M.; Email Address: charles.gieseker@fda.hhs.gov Serfling, S.G. 1 Reimschuessel, R. 1; Affiliation: 1: United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA; Source Info: Mar2006, Vol. 253 Issue 1-4, p120; Subject Term: RAINBOW trout; Subject Term: DEATH (Biology); Subject Term: FISHES; Subject Term: FORMALDEHYDE; Author-Supplied Keyword: Control; Author-Supplied Keyword: Formalin; Author-Supplied Keyword: Saprolegnia; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.aquaculture.2005.07.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Zhan, CL;
AU - Hicks, RW;
AU - Blanchette, CM;
AU - Keyes, MA;
AU - Cousins, DD;
T1 - Potential benefits and problems with computerized prescriber order entry: Analysis of a voluntary medication error-reporting database
CT - Potential benefits and problems with computerized prescriber order entry: Analysis of a voluntary medication error-reporting database
JO - American Journal of Health-System Pharmacy (USA)
JF - American Journal of Health-System Pharmacy (USA)
Y1 - 2006/04/01/
VL - 63
IS - Apr
SP - 353
EP - 358
SN - 10792082
AD - Agcy Healthcare Res & Qual, Rockville, MD 20850, USA czhan@ahrq.gov
N1 - Accession Number: 43-06582; Language: English; References: 17; Journal Coden: AHSPEK; Human Indicator: Yes; Section Heading: Information Processing and Literature; Sociology, Economics and Ethics
N2 - Purpose. The potential benefits and problems associated with computerized prescriber-order-entry (CPOE) systems were studied. Methods. A national voluntary medication error-reporting database, Medmarx, was used to compare facilities that had CPOE with those that did not have CPOE. The characteristics of medication errors reportedly caused by CPOE were explored, and the text descriptions of these errors were qualitatively analyzed. Results. Facilities with CPCE reported fewer inpatient medication errors and more outpatient medication errors than facilities without CPOE, but the statistical significance of these differences could not be determined. Facilities with CPOE less frequently reported medication errors that reached patients (p < 0.01) or harmed patients (p < 0.01). More than 7000 CPOE-related medication errors were reported over seven months in 2003, and about 0.1% of them resulted in harm or adverse events. The most common CPOE errors were dosing errors (i.e., wrong dose, wrong dosage form, or extra dose). Both quantitative and qualitative analyses indicate that CPCE could lead to medication errors not only because of faulty computer interface, miscommunication with other systems, and lack of adequate decision support but also because of common human errors such as knowledge deficit, distractions, inexperience, and typing errors. Conclusion. A national, voluntary medication error-reporting database cannot be used to determine the effectiveness of a CPOE system in reducing medication errors because of the variability in the number of reports from different institutions. However, it may provide valuable information on the specific types of errors related to CPOE systems.
KW - Computers--databases;
KW - Errors, medication--reports;
KW - Medication orders--computers;
KW - Interventions--errors, medication;
KW - Databases--computers;
KW - Reports--errors, medication;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Smith, SR;
AU - Catellier, DJ;
AU - Conlisk, EA;
AU - Upchurch, GA;
T1 - Effect on health outcomes of a community-based medication therapy management program for seniors with limited incomes
CT - Effect on health outcomes of a community-based medication therapy management program for seniors with limited incomes
JO - American Journal of Health-System Pharmacy (USA)
JF - American Journal of Health-System Pharmacy (USA)
Y1 - 2006/04/01/
VL - 63
IS - Apr
SP - 372
EP - 379
SN - 10792082
AD - Reprints: Agcy Healthcare Res & Qual, Ctr Outcomes & Evidence, 540 Gaither Rd, Rockville, MD 20850, USA ssmith@ahrq.gov
AD - Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC, USA
N1 - Accession Number: 43-06541; Language: English; References: 36; Journal Coden: AHSPEK; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Pharmacy Practice
KW - Sociology--low income;
KW - Geriatrics--pharmaceutical care;
KW - Pharmacy services--community;
KW - Interventions--pharmaceutical care;
KW - Pharmaceutical care--geriatrics;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Liying Wang
AU - Scabilloni, James F.
AU - Antonini, James M.
AU - Rojanasakui, Yon
AU - Castranova, Vincent
AU - Mercer, Robert R.
T1 - Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2006/04//
VL - 34
IS - 4
M3 - Article
SP - 695
EP - 702
SN - 10400605
AB - Uncontrolled apoptosis has been associated with several pulmonary disorders; however, the molecular mechanism underlying this process and the fate of apoptotic cells in vivo are unclear. Here we show that direct administration of apoptotic cells to the lungs of rats caused pulmonary inflammation and fibrosis, as indicated by emigration of inflammatory cells to the air spaces, TNF-α immunoreactivity, and connective tissue accumulation, indicating a direct relationship between apoptotic cells and the observed lung pathologies. To determine how the lungs process the accumulated apoptotic cells, normal or apoptotic cells from autologous donor rats were labeled with fluorescent nanobeads and intratracheally instilled into the lungs of rats. Probe distribution and lung cell apoptosis were determined at various times over a 28-day period by confocal fluorescence microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, respectively. Labeled apoptotic cells were cleared by lung macrophages within 1 wk after the treatment. However, the total number of apoptotic cells in the lung remained high at 28 days posttreatment. The results indicate a continuous induction of secondary apoptosis by apoptotic cell instillation, which may contribute to the observed lung pathology. Analysis of lung cell apoptosis by caspase assays showed an elevation of caspase-8 but not caspase-9 in the treatment group at 28 days posttreatment, indicating involvement of the death receptor-mediated pathway in the apoptotic process. Together, our results demonstrate a direct effect of apoptotic cell accumulation on inflammatory and fibrotic pulmonary responses and the continuous induction of lung cell apoptosis by apoptotic cell instillation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - LUNG diseases
KW - RATS as laboratory animals
KW - PULMONARY fibrosis
KW - FLUORESCENCE microscopy
KW - MACROPHAGES
KW - Brown Norway (BN/CrlBR) rat
KW - caspase-8
KW - clearance
KW - pulmonary disorders
N1 - Accession Number: 20495545; Liying Wang 1; Email Address: lmw6@cdc.gov Scabilloni, James F. 1 Antonini, James M. 1 Rojanasakui, Yon 2 Castranova, Vincent 1 Mercer, Robert R. 1; Affiliation: 1: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, West Virginia University Health Sciences Center, Morgantown, West Virginia 2: Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia; Source Info: Apr2006, Vol. 34 Issue 4, p695; Subject Term: APOPTOSIS; Subject Term: LUNG diseases; Subject Term: RATS as laboratory animals; Subject Term: PULMONARY fibrosis; Subject Term: FLUORESCENCE microscopy; Subject Term: MACROPHAGES; Author-Supplied Keyword: Brown Norway (BN/CrlBR) rat; Author-Supplied Keyword: caspase-8; Author-Supplied Keyword: clearance; Author-Supplied Keyword: pulmonary disorders; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 4 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1152/ajplung.00245.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Libby, Anne M.
AU - Orton, Heather D.
AU - Spicer, Paul
AU - Barth, Richard P.
AU - Webb, Mary Bruce
AU - Burns, Barbara J.
AU - Wood, Patricia
T1 - Alcohol, Drug, and Mental Health Specialty Treatment Services and Race/Ethnicity: A National Study of Children and Families Involved With Child Welfare.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/04//
VL - 96
IS - 4
M3 - Article
SP - 628
EP - 631
PB - American Public Health Association
SN - 00900036
AB - We used data on a national sample of children involved with child welfare systems to compare American Indian caregivers with White, Black, and Hispanic caregivers in their need for, and receipt of, specialty alcohol, drug, and mental health treatment. American Indian caregivers were significantly less likely to receive services than were Hispanic caregivers (P<.05) but not significantly less likely than were White or Black caregivers. Child placement, child age, and caregiver psychiatric comorbidity were significantly associated with service receipt. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Child welfare
KW - Caregivers
KW - Native Americans
KW - Hispanic Americans
KW - Family policy
KW - Public welfare
N1 - Accession Number: 20473602; Libby, Anne M. 1; Email Address: anne.libby@uchsc.edu; Orton, Heather D. 1; Spicer, Paul 1; Barth, Richard P. 2; Webb, Mary Bruce 3; Burns, Barbara J. 4; Wood, Patricia 5; Affiliations: 1: American Indian and Alaskan Native Programs, University of Colorado, Denver, and Health Sciences Center, Aurora; 2: University of North Carolina, Chapel Hill; 3: Administration for Children and Families, US Department of Health and Human Services, Washington, DC; 4: Duke University, Durham, NC; 5: Child and Adolescent Services Research Center, San Diego, Calif.; Issue Info: Apr2006, Vol. 96 Issue 4, p628; Subject Term: Child welfare; Subject Term: Caregivers; Subject Term: Native Americans; Subject Term: Hispanic Americans; Subject Term: Family policy; Subject Term: Public welfare; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 4p; Document Type: Article; Full Text Word Count: 2542
L3 - 10.2105/AJPH.2004.059436
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Groom, Amy V.
AU - Cheek, James E.
AU - Bryan, Ralph T.
T1 - Effect of a National vaccine Shortage on Vaccine Coverage for American Indian/Alaska Native Children.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/04//
VL - 96
IS - 4
M3 - Article
SP - 697
EP - 701
PB - American Public Health Association
SN - 00900036
AB - Objectives. We determined the effect of national vaccine shortages on coverage with 4 doses of diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine for American Indian/Alaska Native (ALAN) children. Methods. Data on DTaP coverage for children aged 19 to 27 months were abstracted from Indian Health Service (IHS) immunization reports. Coverage with the fourth DTaP dose (DTaP4) was compared for different periods to determine coverage levels before, during, and after the shortage. Data were stratified geographically to determine regional variation. Results. AIAN children experienced a significant decline (14.8%) in DTaP4 coverage during the shortage. Considerable variation was seen among IHS regions (declines ranged from 4.5% to 26.5%). Conclusions. AIAN children included in IHS immunization reports experienced a greater decline in DTaP4 coverage during the shortage than the decline reported nationally for children receiving vaccine at public clinics (14.8% vs 6%). Variations in the decline in coverage highlight possible inequities in vaccine supply and distribution and in implementation of vaccine shortage recommendations. We must identify ways to ensure more equitable vaccine distribution and consistent implementation of vaccine recommendations to protect all children from vaccine-preventable diseases. (Am J Public Health. 2006;96:697-701. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - DIPHTHERIA
KW - TETANUS toxin
KW - BIOLOGICALS
KW - CORYNEBACTERIUM diseases
KW - BACTERIAL toxins
KW - CLOSTRIDIUM tetani
N1 - Accession Number: 20473614; Groom, Amy V. 1 Cheek, James E. 2 Bryan, Ralph T. 3; Email Address: rrb2@cdc.gov; Affiliation: 1: Program Operations Branch, Immunization Services Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga, 2: Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service 3: Office of Minority Health and Health Disparities, Office of Strategy and Innovation, Office of the Director, Centers for Disease Control and Prevention; Source Info: Apr2006, Vol. 96 Issue 4, p697; Subject Term: VACCINES; Subject Term: DIPHTHERIA; Subject Term: TETANUS toxin; Subject Term: BIOLOGICALS; Subject Term: CORYNEBACTERIUM diseases; Subject Term: BACTERIAL toxins; Subject Term: CLOSTRIDIUM tetani; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 3615
L3 - 10.2105/AJPH.2004.053413
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20473614&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colliver, James D.
AU - Compton, Wilson M.
AU - Gfroerer, Joseph C.
AU - Condon, Timothy
T1 - Projecting Drug Use Among Aging Baby Boomers in 2020
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2006/04//
VL - 16
IS - 4
M3 - Article
SP - 257
EP - 265
SN - 10472797
AB - Purpose: Greater rates of lifetime drug use among the baby-boom generation, combined with the size of that generation, suggest that the number of elderly persons using drugs will increase in the next two decades. Given the potential public health demands implied by increasing numbers of elderly drug users, the goal is to project the numbers of current drug users aged 50 years and older in 2020. Methods: Using the modeling and projection methods of Gfroerer et al (2003) applied to data from the 1999 to 2001 National Household Surveys on Drug Abuse, projections were developed for the use of marijuana, nonmedical use of any prescription-type psychotherapeutic drug, and any illicit drug use. Results: From 1999 to 2001 to 2020, past-year marijuana use in persons 50 years and older is forecast to increase from 1.0% to 2.9%. The number of users is expected to increase from 719,000 to almost 3.3 million, reflecting the combined effects of the increase in rate of use and a projected 51.9% increase in the civilian noninstitutionalized population in this age group. Use of any illicit drug will increase from 2.2% (1.6 million) to 3.1% (3.5 million), and nonmedical use of psychotherapeutic drugs will increase from 1.2% (911,000) to 2.4% (almost 2.7 million). Conclusions: These projections call attention to changes to be considered in planning and to the need for improved knowledge of the biomedical and psychosocial effects of nonmedical drug use on aging and elderly individuals. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BABY boom generation
KW - DRUG abuse
KW - OLDER people
KW - HOUSEHOLD surveys
KW - SUBSTANCE use
KW - Drug Abuse
KW - Drug Use
KW - Elderly
KW - Forecasting
KW - Model
KW - National Household Surveys on Drug Abuse ( NHSDA )
KW - National Survey on Drug Use and Health ( NSDUH )
KW - odds ratio ( OR )
N1 - Accession Number: 20185214; Colliver, James D. 1 Compton, Wilson M.; Email Address: wcompton@nida.nih.gov Gfroerer, Joseph C. 1 Condon, Timothy 1; Affiliation: 1: From the National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (W.M.C., T.C.); and Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Department of Health and Human Services, Rockville, MD (J.D.C., J.C.G.); Source Info: Apr2006, Vol. 16 Issue 4, p257; Subject Term: BABY boom generation; Subject Term: DRUG abuse; Subject Term: OLDER people; Subject Term: HOUSEHOLD surveys; Subject Term: SUBSTANCE use; Author-Supplied Keyword: Drug Abuse; Author-Supplied Keyword: Drug Use; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Forecasting; Author-Supplied Keyword: Model; Author-Supplied Keyword: National Household Surveys on Drug Abuse ( NHSDA ); Author-Supplied Keyword: National Survey on Drug Use and Health ( NSDUH ); Author-Supplied Keyword: odds ratio ( OR ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.annepidem.2005.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20185214&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - PETERS, THOMAS M.
AU - HEITBRINK, WILLIAM A.
AU - EVANS, DOUGLAS E.
AU - SLAVIN, THOMAS J.
AU - MAYNARD, ANDREW D.
T1 - The Mapping of Fine and Ultrafine Particle Concentrations in an Engine Machining and Assembly Facility.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2006/04//
VL - 50
IS - 3
M3 - Article
SP - 249
EP - 257
SN - 00034878
AB - Aerosol mapping was used to assess particle number and mass concentration in an engine machining and assembly facility in the winter and spring. Number and mass concentration maps were constructed from data collected with two mobile sampling carts, each equipped with a condensation particle counter (10 nm < diameter < 1 μm) and an optical particle counter (300 nm < diameter < 20 μm). Number concentrations inside the facility ranged from 15 to 150 times greater than that outside the facility and were highly dependent on season. The greatest number concentration (>1 000 000 particles cm−3) occurred in winter in an area where mass concentration was low (<0.10 mg m−3). The increased number of particles was attributed to the exhaust of direct-fire, natural-gas burners used to heat the supply air. The greatest mass concentrations were found around metalworking operations that were poorly enclosed. The larger particles that dominated particle mass in this area were accompanied by ultrafine particles, probably generated through evaporation and subsequent condensation of metalworking fluid components. Repeat mapping events demonstrated that these ultrafine particles persist in workplace air over long time periods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Particles
KW - Condensation
KW - Cartography
KW - Machining
KW - Manufacturing processes
KW - Metalworking industries
KW - Work environment
KW - aerosol
KW - aerosol mapping
KW - mass concentration
KW - nanoparticles
KW - number concentration
KW - particle
KW - ultrafine
N1 - Accession Number: 20508828; PETERS, THOMAS M. 1; Email Address: thomas-m-peters@uiowa.edu; HEITBRINK, WILLIAM A. 1; EVANS, DOUGLAS E. 2; SLAVIN, THOMAS J. 3; MAYNARD, ANDREW D. 2; Affiliations: 1: Department of Occupational and Environmental Health, University of Iowa, 102 IREH, 100 Oakdale Campus, Iowa City, IA 52242-5000, USA; 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, MS–R3 Cincinnati, OH 45226, USA; 3: International Truck and Engine Corporation, 4201 Winfield Rd, Warrenville, IL 60555, USA; Issue Info: Apr2006, Vol. 50 Issue 3, p249; Thesaurus Term: Particles; Thesaurus Term: Condensation; Subject Term: Cartography; Subject Term: Machining; Subject Term: Manufacturing processes; Subject Term: Metalworking industries; Subject Term: Work environment; Author-Supplied Keyword: aerosol; Author-Supplied Keyword: aerosol mapping; Author-Supplied Keyword: mass concentration; Author-Supplied Keyword: nanoparticles; Author-Supplied Keyword: number concentration; Author-Supplied Keyword: particle; Author-Supplied Keyword: ultrafine; NAICS/Industry Codes: 541360 Geophysical Surveying and Mapping Services; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; Number of Pages: 9p; Illustrations: 7 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1093/annhyg/mei061
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20508828&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - BAŁAZY, ANNA
AU - TOIVOLA, MIKA
AU - REPONEN, TIINA
AU - PODGÓRSKI, ALBERT
AU - ZIMMER, ANTHONY
AU - GRINSHPUN, SERGEY A.
T1 - Manikin-Based Performance Evaluation of N95 Filtering-Facepiece Respirators Challenged with Nanoparticles.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2006/04//
VL - 50
IS - 3
M3 - Article
SP - 259
EP - 269
SN - 00034878
AB - Protection of the human respiratory system from exposure to nanoparticles is becoming an emerging issue in occupational hygiene. The potential adverse health effects associated with particles of ∼1–100 nm are probably greater than submicron or micron-sized particles. The performance of two models of N95 half-facepiece-filtering respirators against nano-sized particles was evaluated at two inhalation flow rates, 30 and 85 l min−1, following a manikin-based protocol. The aerosol concentration was measured outside and inside the facepiece using the Wide-Range Particle Spectrometer. Sodium chloride particles, conventionally used to certify N-series respirators under NIOSH 42 CFR 84 regulations, were utilized as the challenge aerosol. The targeted particle sizes ranged from 10 to 600 nm, although the standard certification tests are performed with particles of ∼300 nm, which is assumed to be the most penetrating size. The results indicate that the nanoparticle penetration through a face-sealed N95 respirator may be in excess of the 5% threshold, particularly at high respiratory flow rates. Thus, N95 respirators may not always provide the expected respiratory protection for workers. The highest penetration values representing the poorest respirator protection conditions were observed in the particle diameter range of ∼30–70 nm. Based on the theoretical simulation, we have concluded that for respirators utilizing mechanical filters, the peak penetration indeed occurs at the particle diameter of ∼300 nm; however, for pre-charged fiber filters, which are commonly used for N95 respirators, the peak shifts toward nano-sizes. This study has confirmed that the neutralization of particles is a crucial element in evaluating the efficiency of a respirator. The variability of the respirator''s performance was determined for both models and both flow rates. The analysis revealed that the coefficient of variation of the penetration ranged from 0.10 to 0.54 for particles of 20–100 nm in diameter. The fraction of N95 respirators for which the performance test at 85 l min−1 demonstrated excessive (>5%) penetration of nanoparticles was as high as 9/10. The test results obtained in a relatively small (0.096 m3) test chamber and in a large (24.3 m3) walk-in chamber were found essentially the same, thus, suggesting that laboratory-based evaluations have a good potential to adequately represent the respirator field performance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Particles
KW - Aerosols (Sprays)
KW - Respiratory organs -- Protection
KW - Nanoparticles
KW - Respirators (Medical equipment)
KW - Mechanical filters (Electrical engineering)
KW - aerosol filtration
KW - electret filter
KW - N95 respirator
KW - penetration
N1 - Accession Number: 20508825; BAŁAZY, ANNA 1; TOIVOLA, MIKA 1; REPONEN, TIINA 1; PODGÓRSKI, ALBERT 2; ZIMMER, ANTHONY 3; GRINSHPUN, SERGEY A. 1; Email Address: sergey.grinshpun@uc.edu; Affiliations: 1: Department of Environmental Health, Center for Health-Related Aerosol Studies, University of Cincinnati, Cincinnati, OH 45267-0056, USA; 2: Department of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland; 3: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA; Issue Info: Apr2006, Vol. 50 Issue 3, p259; Thesaurus Term: Particles; Thesaurus Term: Aerosols (Sprays); Subject Term: Respiratory organs -- Protection; Subject Term: Nanoparticles; Subject Term: Respirators (Medical equipment); Subject Term: Mechanical filters (Electrical engineering); Author-Supplied Keyword: aerosol filtration; Author-Supplied Keyword: electret filter; Author-Supplied Keyword: N95 respirator; Author-Supplied Keyword: penetration; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 11p; Illustrations: 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mei058
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20508825&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sréter-Lancz, Z.
AU - Széll, Z.
AU - Kovács, G.
AU - Egyed, L.
AU - Márialigeti, K.
AU - Sréter, T.
T1 - Rickettsiae of the spotted-fever group in ixodid ticks from Hungary: identification of a new genotype ('Candidatus Rickettsia kotlanii').
JO - Annals of Tropical Medicine & Parasitology
JF - Annals of Tropical Medicine & Parasitology
Y1 - 2006/04//
VL - 100
IS - 3
M3 - Article
SP - 229
EP - 236
PB - Taylor & Francis Ltd
SN - 00034983
AB - Three common European 'anthrophilic' ticks, Ixodes ricinus, Haemaphysalis concinna and Dermacentor reticulatus, were collected in Hungary and tested, in assays based on nested PCR, for rickettsiae of the spotted-fever group. Low percentages of I. ricinus (2.7%) and H. concinna (1.0%) and a high percentage of D. reticulatus (26.8%) were found to be infected. The rickettsiae in the ticks were then identified, by sequencing of the genes coding for 16S ribosomal RNA (16S rDNA), citrate synthase (gltA) and the rOmpA outer-membrane protein (ompA), as Rickettsia helvetica, Rickettsia monacensis, Rickettsia sp. RpA4, or what is probably a newly recognized Rickettsia species ('Candidatus Rickettsia kotlanii'). These results raise the possibility that rickettsiae other than Rickettsia slovaca are involved in human disease in Hungary. Current knowledge on the distributions of the rickettsiae of the spotted-fever group that are emerging in Europe is also summarized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Tropical Medicine & Parasitology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CASTOR bean tick
KW - ROCKY Mountain spotted fever tick
KW - RICKETTSIAS
KW - RESEARCH
KW - RICKETTSIAL diseases
KW - HAEMAPHYSALIS
KW - DERMACENTOR
KW - POLYMERASE chain reaction
KW - HUNGARY
N1 - Accession Number: 20507212; Sréter-Lancz, Z. 1,2 Széll, Z. 3 Kovács, G. 4 Egyed, L. 5 Márialigeti, K. 1 Sréter, T. 3; Email Address: sretert@oai.hu; Affiliation: 1: Department of Microbiology, Eötvös Loránd University, H—1117 Budapest, Pázmány Péter sétány 1, Hungary; Department of Microbiology, National Institute for Food Investigations, H—1095, Budapest, Mester u. 81, Hungary 2: Department of Microbiology, Eötvös Loránd University, H—1117 Budapest, Pázmány Péter sétány 1, Hungary 3: Department of Parasitology, Central Veterinary Institute, H—1149 Budapest, Tábornok u. 2, Hungary 4: Department of Public Health Biology, National Public Health Service, H—1138 Budapest, Váci út 147, Hungary 5: Veterinary Research Institute of the Hungarian Academy of Sciences, H—1143 Budapest, Hungária krt. 21, Hungary; Source Info: Apr2006, Vol. 100 Issue 3, p229; Subject Term: CASTOR bean tick; Subject Term: ROCKY Mountain spotted fever tick; Subject Term: RICKETTSIAS; Subject Term: RESEARCH; Subject Term: RICKETTSIAL diseases; Subject Term: HAEMAPHYSALIS; Subject Term: DERMACENTOR; Subject Term: POLYMERASE chain reaction; Subject Term: HUNGARY; Number of Pages: 8p; Illustrations: 3 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1179/136485906X91468
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20507212&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volokhov, Dmitriy
AU - George, Joseph
AU - Anderson, Christine
AU - Duvall, Robert E.
AU - Hitchins, Anthony D.
T1 - Discovery of Natural Atypical Nonhemolytic Listeria seeligeri Isolates.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/04//
VL - 72
IS - 4
M3 - Article
SP - 2439
EP - 2448
SN - 00992240
AB - We found seven Listeria isolates, initially identified as isolates with the Xyl+ Rha- biotype of Listeria welshimeri by phenotypic tests, which exhibited discrepant genotypic properties in a well-validated Listeria species identification oligonucleotide microarray. The microarray gives results of these seven isolates being atypical hly-negative L. seeligeri isolates, not L. welshimeri isolates. The aberrant L. seeligeri isolates were ᴅ-xylose fermentation positive, ʟ-rhamnose fermentation negative (Xyl+ Rha-), and nonhemolytic on blood agar and in the CAMP test with both Staphylococcus aureus (S- reaction) and Rhodococcus equi (R- reaction). All genes of the prfA cluster of L. seeligeri, located in the prs-ldh region, including the orfA2, orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, orfI, orfP, orfB, and orfA genes, were checked by PCR and direct sequencing for evidence of their presence in the atypical isolates. The prs-prfA cluster-/dh region of the L. seeligeri isolates was approximately threefold shorter due to the loss of orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, and orfI. The genetic map order of the cluster genes of all the atypical L. seeligeri isolates was prs-orfA2-orfP-orfB-orfA-ldh, which was comparable to the similar region in L. welshimeri, with the exception of the presence of orfA2. DNA sequencing and phylogenetic analysis of 17 housekeeping genes indicated an L. seeligeri genomic background in all seven of the atypical hly-negative L. seeligeri isolates. Thus, the novel biotype of Xyl+ Rha- Hly- L. seeligeri strains can only be distinguished from Xyl+ Rha- L. welshimeri strains genotypically, not phenotypically. In contrast, the Rha+ Xyl+ biotype of L. welshimeri would not present an identification issue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATYPICAL mycobacteria
KW - MYCOBACTERIA
KW - BACTERIAL genetics
KW - NUCLEOTIDE sequence
KW - PHENOTYPE
KW - LISTERIA
KW - GENETICS
KW - HEREDITY
KW - BACTERIA
N1 - Accession Number: 20780372; Volokhov, Dmitriy 1; Email Address: volokhov@cber.fda.gov George, Joseph 1 Anderson, Christine 1 Duvall, Robert E. 2 Hitchins, Anthony D. 2; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Kensington, Maryland 20895 2: Center for Food Safely and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740-38352; Source Info: Apr2006, Vol. 72 Issue 4, p2439; Subject Term: ATYPICAL mycobacteria; Subject Term: MYCOBACTERIA; Subject Term: BACTERIAL genetics; Subject Term: NUCLEOTIDE sequence; Subject Term: PHENOTYPE; Subject Term: LISTERIA; Subject Term: GENETICS; Subject Term: HEREDITY; Subject Term: BACTERIA; Number of Pages: 10p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1128/AEM.72.4.2439-2448.2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20780372&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Monday, Steven R.
AU - Keys, Christina
AU - Hanson, Patricia
AU - Yuelian Shen
AU - Whittam, Thomas S.
AU - Peter Feng
T1 - Produce Isolates of the Escherichia coli Ont:H52 Serotype That Carry both Shiga Toxin 1 and Stable Toxin Genes.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/04//
VL - 72
IS - 4
M3 - Article
SP - 3062
EP - 3065
SN - 00992240
AB - Produce isolates of the Escherichia coli Ont:H52 serotype carried Shiga toxin 1 and stable toxin genes but only expressed Stx1. These strains had pulsed-field gel electrophoresis profiles that were 90% homologous to clinical Ont:H52 strains that had identical phenotypes and genotypes. All Ont:H52 strains had identical single nucleotide polymorphism profiles that are suggestive of a unique clonal group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - TOXINS
KW - GENES
KW - GEL electrophoresis
KW - PHENOTYPE
KW - NUCLEOTIDES
KW - GENETIC polymorphisms
KW - ESCHERICHIA
KW - MICROORGANISMS
KW - MICROBIOLOGY
N1 - Accession Number: 20780450; Monday, Steven R. 1 Keys, Christina 1 Hanson, Patricia 2 Yuelian Shen 2 Whittam, Thomas S. 3 Peter Feng 1; Email Address: pfeng@cfsan.fda.gov; Affiliation: 1: Division of Microbiological Studies, U.S. Food and Drug Administration, College Park, Maryland 20740 2: Florida Department of Agriculture and Consumer Services, Tallahassee, Florida 32339 3: STEC Center, Michigan State University, East Lansing, Michigan 48824; Source Info: Apr2006, Vol. 72 Issue 4, p3062; Subject Term: ESCHERICHIA coli; Subject Term: TOXINS; Subject Term: GENES; Subject Term: GEL electrophoresis; Subject Term: PHENOTYPE; Subject Term: NUCLEOTIDES; Subject Term: GENETIC polymorphisms; Subject Term: ESCHERICHIA; Subject Term: MICROORGANISMS; Subject Term: MICROBIOLOGY; Number of Pages: 4p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1128/AEM.72.4.3062-3065.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Brent A.
AU - Mercer, Robert R.
AU - Geronilla, Ken B.
AU - Kashon, Michael L.
AU - Miller, G. R.
AU - Cutlip, Robert G.
T1 - Stereological analysis of muscle morphology following exposure to repetitive stretch-shortening cycles in a rat model.
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
Y1 - 2006/04//
VL - 31
IS - 2
M3 - Article
SP - 167
EP - 179
PB - Canadian Science Publishing
SN - 17155312
AB - Repetitive motion is one risk factor associated with contraction-induced muscle injury, which leads to skeletal muscle degeneration, inflammation, and dysfunction. Since current methods are unable to quantify the acute degenerative and inflammatory responses of muscle tissue concurrently, the purpose of this study was to quantify the temporal myofiber response after exposure to injurious stretch–shortening cycles (SSCs) using a standardized stereological technique. Functional testing was performed on the ankle dorsiflexor muscles of Sprague–Dawley rats in vivo. Rats were anesthetized and exposed to 15 sets of 10 SSCs. Control rats were exposed to 15 sets of single isometric contractions of the same stimulation duration. Changes in muscle morphometry were assessed at 0.5, 24, 48, 72, and 240 h post-exposure to quantify the degree of myofiber degeneration and inflammation in the tibialis anterior muscle from each group. There was an increase in the volume density and average thickness of degenerating myofibers over time in the muscle collected from rats exposed to SSCs (p < 0.0001) that was significantly greater than in muscle exposed to isometric contractions at 24, 48, and 72 h post-exposure (p = 0.003). The volume density of degenerative myofibers was associated with functional deficits at 48 h. Stereological quantification of degenerative myofibers and interstitial space changes were associated with functional defects 48–72 h after SSC-induced injury, thus demonstrating stereology is an accurate measure of SSC-induced skeletal muscle injury. (English) [ABSTRACT FROM AUTHOR]
AB - Le mouvement répétitif est un des facteurs de risque associé aux lésions musculaires du fait même des contractions musculaires, ce qui entraîne une dégénérescence du muscle, une inflammation et une dysfonction. Les méthodes courantes ne quantifiant pas en même temps la dégénérescence et l'inflammation du tissu musculaire, cette étude se propose de quantifier l'évolution chronologique de la fibre musculaire à la suite d'une série nocive d'actions d'étirement–contraction (SSCs) du muscle, et ce, au moyen d'une technique stéréologique. L'évaluation fonctionnelle est réalisée in vivo sur les fléchisseurs dorsaux de la cheville de rats Sprague–Dawley. On soumet les rats anesthésiés à 15 séries d'actions cycliques d'étirement-contraction. Les rats témoins sont soumis à 15 séries d'actions isométriques d'une même durée. Afin de quantifier le niveau de dégénérescence et d'inflammation des fléchisseurs dorsaux de chaque groupe, les modifications myomorphométriques sont analysées 0,5, 24, 48, 72, et 240 h après les séries d'actions. On observe avec le temps une augmentation de la densité volumique et de l'épaisseur moyenne des fibres en dégénérescence dans les muscles des rats soumis aux actions cycliques d'étirement-contraction (p < 0,0001); cette augmentation est significativement plus importante que celle observée dans les muscles soumis aux actions isométriques 24, 48, et 72 h après coup (p = 0,003). La densité volumique des fibres en dégénérescence est associée aux déficits fonctionnels observés 48 h après les séries d'actions. La quantification stéréologique des fibres musculaires en dégénérescence et les modifications du milieu interstitiel sont associées aux déficits fonctionnels observés 48 à 72 h après les séries d'actions nocives de SSC; la stéréologie permet donc de mesurer avec précision les lésions dues aux SSC. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Physiology, Nutrition & Metabolism is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLES -- Physiology
KW - MORPHOLOGY
KW - STEREOLOGY
KW - SCIENTIFIC method
KW - OVERUSE injuries
KW - RATS as laboratory animals
KW - interstitial space
KW - morphometry
KW - myofiber degeneration
KW - stereology
KW - stretch-shortening cycles
KW - actions cycliques d'étirementcontraction
KW - actions cycliques d'étirement-contraction
KW - dégénérescence myofibrillaire
KW - dégénérescence myofibrillaire
KW - milieu interstitiel
KW - morphométrie
KW - morphométrie
KW - stéréologie
KW - stéréologie
N1 - Accession Number: 23196025; Baker, Brent A. 1 Mercer, Robert R. 1 Geronilla, Ken B. 1 Kashon, Michael L. 1 Miller, G. R. 1 Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, 1095 Don Nehlen Drive, M/S 2027, Morgantown, WV 26505, USA; Source Info: Apr2006, Vol. 31 Issue 2, p167; Subject Term: MUSCLES -- Physiology; Subject Term: MORPHOLOGY; Subject Term: STEREOLOGY; Subject Term: SCIENTIFIC method; Subject Term: OVERUSE injuries; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: interstitial space; Author-Supplied Keyword: morphometry; Author-Supplied Keyword: myofiber degeneration; Author-Supplied Keyword: stereology; Author-Supplied Keyword: stretch-shortening cycles; Author-Supplied Keyword: actions cycliques d'étirementcontraction; Author-Supplied Keyword: actions cycliques d'étirement-contraction; Author-Supplied Keyword: dégénérescence myofibrillaire; Author-Supplied Keyword: dégénérescence myofibrillaire; Author-Supplied Keyword: milieu interstitiel; Author-Supplied Keyword: morphométrie; Author-Supplied Keyword: morphométrie; Author-Supplied Keyword: stéréologie; Author-Supplied Keyword: stéréologie; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1139/H05-009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106224692
T1 - Stereological analysis of muscle morphology following exposure to repetitive stretch-shortening cycles in a rat model.
AU - Baker BA
AU - Mercer RR
AU - Geronilla KB
AU - Kashon ML
AU - Miller GR
AU - Cutlip RG
Y1 - 2006/04//
N1 - Accession Number: 106224692. Language: English. Entry Date: 20070126. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. NLM UID: 101264333.
KW - Cumulative Trauma Disorders -- Physiopathology
KW - Isometric Contraction -- Physiology
KW - Muscle, Skeletal -- Injuries
KW - Muscle, Skeletal -- Pathology
KW - Animal Studies
KW - Control Group
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Dynamometry
KW - Electrical Stimulation, Neuromuscular
KW - Experimental Studies
KW - Fisher's Exact Test
KW - Inflammation
KW - Male
KW - Microscopy
KW - Post Hoc Analysis
KW - Random Assignment
KW - Rats
KW - Recovery, Exercise -- Physiology
KW - Two-Way Analysis of Variance
SP - 167
EP - 179
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
JA - APPL PHYSIOL NUTR METAB
VL - 31
IS - 2
CY - Ottawa, Ontario
PB - Canadian Science Publishing
SN - 1715-5312
AD - National Institute for Occupational Safety and Health, Morgantown, VA 26505, USA.
U2 - PMID: 16604135.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106224692&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106447758
T1 - Recently approved pharmaceutical agent sinitinib malate (SUTENT) [corrected] [published erratum appears in ASCO NEWS FORUM 2006 Jul;1(3):35].
AU - Rock E
AU - Goodman V
AU - Dagher R
AU - Cohen M
AU - Justice R
Y1 - 2006/04//2006 Apr
N1 - Accession Number: 106447758. Language: English. Entry Date: 20060526. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA.
KW - Drug Approval
KW - Enzyme Inhibitors -- Therapeutic Use
KW - Gastrointestinal Neoplasms -- Drug Therapy
KW - Kidney Neoplasms -- Drug Therapy
KW - Clinical Trials
KW - Disease Progression
KW - Enzyme Inhibitors -- Administration and Dosage
KW - Enzyme Inhibitors -- Adverse Effects
KW - Enzyme Inhibitors -- Metabolism
KW - Enzyme Inhibitors -- Pharmacodynamics
KW - Enzyme Inhibitors -- Pharmacokinetics
KW - Treatment Outcomes
KW - United States Food and Drug Administration
SP - 27
EP - 56
JO - ASCO News & Forum
JF - ASCO News & Forum
JA - ASCO NEWS FORUM
VL - 1
IS - 2
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 1931-7646
AD - Division of Drug Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106328315
T1 - Carolyn Maureen Clancy, MD: a conversation with the editor.
AU - Roberts WC
Y1 - 2006/04//2006 Apr
N1 - Accession Number: 106328315. Language: English. Entry Date: 20060901. Revision Date: 20150711. Publication Type: Journal Article; interview; pictorial. Commentary: Ramsay MAE. Baylor Health Care System: sharing the vision of the quality challenge. (BAYLOR UNIV MED CENT PROC) 2006 Apr; 19 (2): 148-148. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9302033.
KW - Health Policy
KW - Physicians
KW - United States Agency for Healthcare Research and Quality -- Administration
KW - Female
SP - 144
EP - 147
JO - Baylor University Medical Center Proceedings
JF - Baylor University Medical Center Proceedings
JA - BAYLOR UNIV MED CENT PROC
VL - 19
IS - 2
CY - Dallas, Texas
PB - Baylor University Medical Center
SN - 0899-8280
AD - Director, Agency for Healthcare Research and Quality, 540 Gaither Road, 3rd Floor, Rockville, MD 20850; CClancy@ahrq.gov
U2 - PMID: 16609742.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106328315&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dobrovolskaia, E.
AU - Gam, A.
AU - Slater, J. E.
T1 - Competition enzyme-linked immunosorbant assay (ELISA) can be a sensitive method for the specific detection of small quantities of allergen in a complex mixture.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2006/04//
VL - 36
IS - 4
M3 - Article
SP - 525
EP - 530
PB - Wiley-Blackwell
SN - 09547894
AB - Rationale The competition ELISA assay is used to determine the potency of US standardized allergen extracts. We have been concerned that the competition ELISA is not sensitive to changes in individual allergen levels. This study was designed to determine the sensitivity of the competition ELISA to detect the specific loss of Bla g 1 and Bla g 2 in cockroach extracts. Methods German cockroach extract E3Cg was made from defatted German cockroaches. New Zealand White rabbits were immunized with rBla g 1 or rBla g 2. Optimal dilutions of anti-Bla g 1 and anti-Bla g 2 sera were established by ELISA. E3Cg was selectively depleted of Bla g 1 or Bla g 2 by immunoabsorption with anti-Bla g 1 or anti-Bla g 2 attached to Protein G agarose beads. Competition ELISA using pooled human sera, or mixed anti-Bla g 1 and anti-Bla g 2 serum, was performed on the depleted extracts, and on depleted extracts reconstituted with rBla g 1 or rBla g 2. Results Unlike pooled human-allergic IgE sera, anti-Bla g 1 and anti-Bla g 2 IgG – in dilutions as low as 10−6, could be used in the competition ELISA to measure the loss of allergen in depleted E3Cg. As little as 0.001 μg/mL of added rBla g 1 and 0.1 μg/mL of added rBla g 2, could be detected. Conclusion The competition ELISA can be highly sensitive to compositional differences in complex allergen mixtures, even when the specific detecting antibody is present in relatively small amounts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Antigens
KW - Cockroaches
KW - Enzyme-linked immunosorbent assay
KW - Immunoenzyme technique
KW - allergen
KW - cockroach
KW - ELISA
KW - potency
KW - standardization
N1 - Accession Number: 20262933; Dobrovolskaia, E. 1; Gam, A. 1; Slater, J. E. 1; Email Address: slaterj@cber.fda.gov; Affiliations: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA; Issue Info: Apr2006, Vol. 36 Issue 4, p525; Thesaurus Term: Allergens; Thesaurus Term: Antigens; Thesaurus Term: Cockroaches; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Immunoenzyme technique; Author-Supplied Keyword: allergen; Author-Supplied Keyword: cockroach; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: potency; Author-Supplied Keyword: standardization; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 3 Color Photographs, 1 Chart, 9 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2222.2006.02466.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106355515
T1 - Demographic characteristics and employment among people with severe mental illness in a multisite study.
AU - Burke-Miller JK
AU - Cook JA
AU - Grey DD
AU - Razzano LA
AU - Blyler CR
AU - Leff HS
AU - Gold PB
AU - Goldberg RW
AU - Mueser KT
AU - Cook WL
AU - Hoppe SK
AU - Stewart M
AU - Blankertz L
AU - Dudek K
AU - Taylor AL
AU - Carey MA
Y1 - 2006/04//
N1 - Accession Number: 106355515. Language: English. Entry Date: 20061103. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 0005735.
KW - Employment of Disabled
KW - Mental Disorders, Chronic -- Rehabilitation
KW - Rehabilitation, Vocational
KW - Adult
KW - Age Factors
KW - Clinical Trials
KW - Demography
KW - Descriptive Statistics
KW - DSM
KW - Female
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Outcome Assessment
KW - P-Value
KW - Prospective Studies
KW - Human
SP - 143
EP - 159
JO - Community Mental Health Journal
JF - Community Mental Health Journal
JA - COMMUNITY MENT HEALTH J
VL - 42
IS - 2
CY - ,
PB - Springer Science & Business Media B.V.
AB - People with psychiatric disabilities experience disproportionately high rates of unemployment. As research evidence is mounting regarding effective vocational programs, interest is growing in identifying subgroup variations. Data from a multisite research and demonstration program were analyzed to identify demographic characteristics associated with employment outcomes, after adjusting for the effects of program, services, and study site. Longitudinal analyses found that people with more recent work history, younger age, and higher education were more likely to achieve competitive employment and to work more hours per month, while race and gender effects varied by employment outcome. Results provide strong evidence of demographic subgroup variation and need.
SN - 0010-3853
AD - Center on Mental Health Services Research and Policy, University of Illinois at Chicago, Chicago, IL, USA, Jburke@psych.uic.edu.
U2 - PMID: 16404685.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goldman, Julian M.
AU - Jackson, Jennifer L.
AU - Whitehead, Susan F.
AU - Rausch, Tracy L.
AU - Weininger, Sandy
T1 - The Medical Device"Plug-and-Play"(MD PnP) Interoperability Program.
JO - Computer (00189162)
JF - Computer (00189162)
Y1 - 2006/04//
VL - 39
IS - 4
M3 - Article
SP - 30
EP - 31
SN - 00189162
AB - The article looks into the Medical Device Plug-and-Play (MD PnP) Interoperability Program launched by the Massachusetts General Hospital (MGH) and the Center for the Integration of Medicine and Innovative Technology (CIMIT). The absence of market-ready interoperability solutions has stalled the development of fully integrated electronic medical records. The establishment of the program was necessary to address medical device interoperability to support the development of connected, error-resistant medical device systems throughout the continuum of healthcare. The impetus for the MD PnP program relies on both the visionary and real foundation provided by the Operating Room of the Future as well the collaboration and extended vision of MGH and CIMIT. Finally, the continued lack of automated safety systems, smart alarms, closed-loop control, and decision support systems are unconscionable in the presence of readily available technology that is applied to similar goals.
KW - MEDICAL equipment
KW - BIOMEDICAL engineering
KW - MEDICAL supplies
KW - SCIENTIFIC apparatus & instruments
KW - PLUG & play (Computer architecture)
KW - COMPUTER architecture
KW - INTERNETWORKING (Telecommunication)
KW - MEDICAL technology
KW - CONTINUUM of care
KW - LONG-term care of the sick
N1 - Accession Number: 20495435; Goldman, Julian M. 1; Email Address: jmgoldman@partners.org Jackson, Jennifer L. 2; Email Address: jljackson@poreners.org Whitehead, Susan F. 3; Email Address: swhitehead@partners.org Rausch, Tracy L. 4; Email Address: tracy.rausch@kp.org Weininger, Sandy 5; Email Address: sandy.weininger@fda.hhs.gov; Affiliation: 1: Director, Medical Device "Plug-and-Play" Interoperability Program, Departments of Anesthesia and Biomedical Engineering, Massachusetts General Hospital, Center for the Integration of Medicine and Innovative Technology 2: Assistant Director, Biomedical Engineering, Brigham And Women's Hospital 3: Program Project Manager, Center For The Integration of Medicine & Innovative Technology 4: Clinical System Engineer, Kaiser Permanente Mid-Atlantic States, Rockville, Md. 5: Senior Regulatory Engineer, FDA Center For Devices And Radiological Health/OSEL/DESE, Rockville, Md.; Source Info: Apr2006, Vol. 39 Issue 4, p30; Subject Term: MEDICAL equipment; Subject Term: BIOMEDICAL engineering; Subject Term: MEDICAL supplies; Subject Term: SCIENTIFIC apparatus & instruments; Subject Term: PLUG & play (Computer architecture); Subject Term: COMPUTER architecture; Subject Term: INTERNETWORKING (Telecommunication); Subject Term: MEDICAL technology; Subject Term: CONTINUUM of care; Subject Term: LONG-term care of the sick; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jetley, Raoul
AU - Iyer, S. Purushothaman
AU - Jones, Paul L.
T1 - A Formal Methods Approach to Medical Device Review.
JO - Computer (00189162)
JF - Computer (00189162)
Y1 - 2006/04//
VL - 39
IS - 4
M3 - Article
SP - 61
EP - 67
SN - 00189162
AB - The article features the formal methods approach to medical device review. Significantly, the U.S. Food and Drug Administration (FDA) needed effective ways of assuring the public that medical software is safe and reliable. The FDA aimed to provide a more rigorous engineering-based review strategy to provide such assistance. However, such strategy were insufficient for assessing software even if regulatory processes work well for device production processes. The FDA Center for Devices and Radiological Health/Office of Science and Engineering Laboratories have worked with university researchers to explore ways to use formal modeling methods and static analysis techniques to improve the review process.
KW - MEDICAL equipment
KW - BIOMEDICAL engineering
KW - MEDICAL supplies
KW - SCIENTIFIC apparatus & instruments
KW - COMPUTER software development
KW - COMPUTER programming -- Management
KW - SYSTEMS design
KW - INFORMATION resources -- Reviews
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20495440; Jetley, Raoul; Email Address: rpjetley@alumni.ncsu.edu Iyer, S. Purushothaman 1; Email Address: purush@csc.ncsu.edu Jones, Paul L. 2; Email Address: PaulL.jones@fda.hhs.gov; Affiliation: 1: Professor, Computer Science Department, North Carolina State University 2: Senior Systems/Software Engineer, US Food and Drug Administration, Center for Devices and Radiological Health/Office of Science and Engineering Laboratories; Source Info: Apr2006, Vol. 39 Issue 4, p61; Subject Term: MEDICAL equipment; Subject Term: BIOMEDICAL engineering; Subject Term: MEDICAL supplies; Subject Term: SCIENTIFIC apparatus & instruments; Subject Term: COMPUTER software development; Subject Term: COMPUTER programming -- Management; Subject Term: SYSTEMS design; Subject Term: INFORMATION resources -- Reviews; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 7p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shafer, Teresa J.
AU - Wagner, Dennis
AU - Chessare, John
AU - Zampiello, Francis A.
AU - McBride, Virginia
AU - Perdue, Jade
T1 - Organ Donation Breakthrough Collaborative. (Cover story)
JO - Critical Care Nurse
JF - Critical Care Nurse
Y1 - 2006/04//
VL - 26
IS - 2
M3 - Article
SP - 33
EP - 47
PB - American Association of Critical-Care Nurses
SN - 02795442
AB - Provides an overview of the Organ Donation Breakthrough Collaborative, initiated by the U.S. Department of Health and Human Services to address the organ donation crisis in the country. Other issues raised related to organ donation; Description of the system redesign for the organ donation process; Information on the top-performing organizations associated with higher rates of organ donation.
KW - DONATION of organs, tissues, etc.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - COLLECTIVE action
KW - ORGAN donors
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 20342584; Shafer, Teresa J. 1,2 Wagner, Dennis 3 Chessare, John 2,4 Zampiello, Francis A. 5 McBride, Virginia 6 Perdue, Jade 6; Affiliation: 1: Executive vice president and chief operating officer, LifeGift Organ Donation Center, Houston, Tex. 2: National cochair, Organ Donation Breakthrough Collaborative 3: Director, Organ Donation Breakthrough Collaborative, Department of Health and Human Services, Rockville, Md. 4: President, Caritas Norwood Hospital, Norwood, Mass. 5: Senior consultant, Quality Reality Checks, Inc., Philadelphia, Pa. 6: Public health analyst, Division of Transplantation at the Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Md.; Source Info: Apr2006, Vol. 26 Issue 2, p33; Subject Term: DONATION of organs, tissues, etc.; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: COLLECTIVE action; Subject Term: ORGAN donors; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Macher, Abe
AU - Kibble, Deborah
AU - Wheeler, David
T1 - HIV Transmission in Correctional Facility.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006/04//
VL - 12
IS - 4
M3 - Article
SP - 669
EP - 671
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Acute retroviral syndrome developed in an inmate in a detention center after he had intercourse with 2 HIV-infected inmates. Correctional facilities house a disproportionate number of HIV-infected persons, and most do not provide inmates with condoms. Correctional healthcare providers should be familiar with primary HIV infection and acute retroviral syndrome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - HIV-positive persons
KW - Institutionalized persons
KW - Condoms
KW - Correctional institutions
N1 - Accession Number: 20372986; Macher, Abe 1; Email Address: abemacher@hotmail.com; Kibble, Deborah 2; Wheeler, David 3; Affiliations: 1: US Public Health Service (retired), Bethesda, Maryland, USA; 2: Metropolitan Washington Council of Governments, Washington, DC, USA; 3: Infectious Diseases Physicians, Annandale, Virginia, USA; Issue Info: Apr2006, Vol. 12 Issue 4, p669; Subject Term: HIV infections; Subject Term: HIV-positive persons; Subject Term: Institutionalized persons; Subject Term: Condoms; Subject Term: Correctional institutions; NAICS/Industry Codes: 326290 Other rubber product manufacturing; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 623990 Other Residential Care Facilities; NAICS/Industry Codes: 911220 Federal correctional services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leighton, John K.
AU - Brown, Paul
AU - Ellis, Amy
AU - Harlow, Patricia
AU - Harrouk, Wafa
AU - Pine, P. Scott
AU - Robison, Timothy
AU - Rosario, Lilliam
AU - Thompson2, Karol
T1 - Workgroup Report: Review of Genomics Data Based on Experience with Mock Submissions -- View of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/04//
VL - 114
IS - 4
M3 - Article
SP - 573
EP - 578
PB - Superintendent of Documents
SN - 00916765
AB - Over the past few years, both the U.S. Food and Drug Administration (FDA) and the pharmaceutical industry have recognized the potential importance of pharmacogenomics and toxicogenomics to drug development. To resolve the uncertainties surrounding the use of microarray technology and the presentation of genomics data for regulatory purposes, several pharmaceutical companies and genomics technology providers have provided the FDA with reports of genomics studies that included supporting toxicology data (e.g., serum chemistry, histopathology). These studies were not associated with any active drug application and were exploratory or hypothesis generating in nature. For training purposes, these reports were reviewed by the Nonclinical Pharmacogenomics Subcommittee consisting of the Center for Drug Evaluation and Research pharmacology and toxicology researchers and reviewers. In this article, we describe some of these submissions and report on our assessment of data content, format, and quality control metrics that were useful for evaluating these nonclinical genomics submissions, specifically in relation to the proposed MIAME/MINTox (minimum information about a microarray experiment/minimum information needed for a toxicology experiment) recommendations. These genomics submissions allowed both researchers and regulators to gain experience in the process of reviewing and analyzing toxicogenomics data. The experience will allow development of recommendations for the submission and review of these data as the state of the science evolves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Medicine
KW - Research
KW - Health
KW - Drug development
KW - Pharmacogenomics
KW - Genomics
KW - Pharmacy
KW - data visualization
KW - electronic data files
KW - MIAME/MINTox
KW - mock submission content
KW - quality control metrics
KW - toxicogenomics
KW - United States. Food & Drug Administration
N1 - Accession Number: 20814557; Leighton, John K. 1; Email Address: leightonj@fda.hhs.gov; Brown, Paul 1; Ellis, Amy 1; Harlow, Patricia 1; Harrouk, Wafa 1; Pine, P. Scott 2; Robison, Timothy 1; Rosario, Lilliam 1; Thompson2, Karol; Affiliations: 1: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; 2: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Issue Info: Apr2006, Vol. 114 Issue 4, p573; Thesaurus Term: Toxicology; Thesaurus Term: Medicine; Thesaurus Term: Research; Thesaurus Term: Health; Subject Term: Drug development; Subject Term: Pharmacogenomics; Subject Term: Genomics; Subject Term: Pharmacy; Author-Supplied Keyword: data visualization; Author-Supplied Keyword: electronic data files; Author-Supplied Keyword: MIAME/MINTox; Author-Supplied Keyword: mock submission content; Author-Supplied Keyword: quality control metrics; Author-Supplied Keyword: toxicogenomics ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.8318
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20814557&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Selgrade, Mary Jane K.
AU - Lemanske Jr., Robert F.
AU - Gilmour, M. Ian
AU - Neas, Lucas M.
AU - Ward, Marsha D. W.
AU - Henneberger, Paul K.
AU - Weissman, David N.
AU - Hoppin, Jane A.
AU - Dietert, Rodney R.
AU - Sly, Peter D.
AU - Geller, Andrew M.
AU - Enright, Paul L.
AU - Backus, Gillian S.
AU - Bromberg, Philip A.
AU - Germolec, Dori R.
AU - Yeatts, Karin B.
T1 - Induction of Asthma and the Environment: What We Know and Need to Know.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/04//
VL - 114
IS - 4
M3 - Article
SP - 615
EP - 619
PB - Superintendent of Documents
SN - 00916765
AB - The prevalence of asthma has increased dramatically over the last 25 years in the United States and in other nations as a result of ill-defined changes in living conditions in modern society. On 18 and 19 October 2004 the U.S. Environmental Protection Agency and the National Institute of Environmental Health Sciences sponsored the workshop "Environmental Influences on the Induction and Incidence of Asthma" to review current scientific evidence with respect to factors that may contribute to the induction of asthma. Participants addressed two broad questions: a) What does the science suggest that regulatory and public health agencies could do now to reduce the incidence of asthma? and b) What research is needed to improve our understanding of the factors that contribute to the induction of asthma and our ability to manage this problem? In this article (one of four articles resulting from the workshop), we briefly characterize asthma and its public health and economic impacts, and intervention strategies that have been successfully used to prevent induction of asthma in the workplace. We conclude with the findings of seven working groups that focus on ambient air, indoor pollutants (biologics), occupational exposures, early life stages, older adults, intrinsic susceptibility, and lifestyle. These groups found strong scientific support for public health efforts to limit in utero and postnatal exposure to cigarette smoke. However, with respect to other potential types of interventions, participants noted many scientific questions, which are summarized in this article. Research to address these questions could have a significant public health and economic impact that would be well worth the investment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Health risk assessment
KW - Air pollution
KW - Public health
KW - Biologicals
KW - Disease susceptibility
KW - Medical sciences
KW - United States
KW - air pollution
KW - allergy
KW - asthma economic impact
KW - asthma induction
KW - asthma prevalence
KW - biologics
KW - indoor environment
KW - occupational exposure
KW - public health
KW - susceptibility
KW - United States. Environmental Protection Agency
N1 - Accession Number: 20814564; Selgrade, Mary Jane K. 1; Email Address: selgrade.maryjane@epa.gov; Lemanske Jr., Robert F. 2; Gilmour, M. Ian 1; Neas, Lucas M. 1; Ward, Marsha D. W. 1; Henneberger, Paul K. 3; Weissman, David N. 3; Hoppin, Jane A. 4; Dietert, Rodney R. 5; Sly, Peter D. 6; Geller, Andrew M. 1; Enright, Paul L. 3; Backus, Gillian S. 4,7; Bromberg, Philip A. 8; Germolec, Dori R. 4; Yeatts, Karin B. 8; Affiliations: 1: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 2: Division of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin, Madison, Wisconsin, USA; 3: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 4: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 5: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; 6: Center for Child Health Research, University of Western Australia, Perth, Australia; 7: Curriculum in Toxicology, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; 8: Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA; Issue Info: Apr2006, Vol. 114 Issue 4, p615; Thesaurus Term: Asthma; Thesaurus Term: Health risk assessment; Thesaurus Term: Air pollution; Thesaurus Term: Public health; Thesaurus Term: Biologicals; Subject Term: Disease susceptibility; Subject Term: Medical sciences; Subject: United States; Author-Supplied Keyword: air pollution; Author-Supplied Keyword: allergy; Author-Supplied Keyword: asthma economic impact; Author-Supplied Keyword: asthma induction; Author-Supplied Keyword: asthma prevalence; Author-Supplied Keyword: biologics; Author-Supplied Keyword: indoor environment; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: public health; Author-Supplied Keyword: susceptibility ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 5p; Document Type: Article
L3 - 10.1289/ehp.8376
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20814564&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yeatts, Karin
AU - Sly, Peter
AU - Shore, Stephanie
AU - Weiss, Scott
AU - Martinez, Fernando
AU - Geller, Andrew
AU - Bromberg, Philip
AU - Enright, Paul
AU - Koren, Hillel
AU - Weissman, David
AU - Selgrade, MaryJane
T1 - A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/04//
VL - 114
IS - 4
M3 - Article
SP - 634
EP - 640
PB - Superintendent of Documents
SN - 00916765
AB - Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma, and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA "Asthma Research Strategy" document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of "susceptibility factors" that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Health risk assessment
KW - Environmental health
KW - Epidemiology
KW - Genetics
KW - Obesity
KW - Medical sciences
KW - asthma
KW - epidemiology
KW - genetics
KW - hygiene hypothesis
KW - incidence
KW - obesity
KW - occupational asthma
KW - smoking
KW - susceptibility
KW - windows of exposure and age (in utero, childhood, adult, elderly)
KW - United States. Environmental Protection Agency
KW - Environmental Health Perspectives (Periodical)
N1 - Accession Number: 20814567; Yeatts, Karin 1; Email Address: Karin_Yeatts@unc.edu; Sly, Peter 2; Shore, Stephanie 3; Weiss, Scott 4; Martinez, Fernando 5; Geller, Andrew 6; Bromberg, Philip 1; Enright, Paul 7; Koren, Hillel 6; Weissman, David 8; Selgrade, MaryJane 6; Affiliations: 1: Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA; 2: Institute for Child Health, Division of Clinical Science, University of Western Australia, Perth, Australia; 3: Harvard School of Public Health, Boston Massachusetts, USA; 4: Harvard Medical School, Boston Massachusetts, USA; 5: University of Arizona, Arizona Respiratory Center, Tucson, Arizona, USA; 6: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 7: University of Arizona, Tucson, Arizona, USA; 8: National Institute for Occupational Safety and Health, Morgantown, West Virgina, USA; Issue Info: Apr2006, Vol. 114 Issue 4, p634; Thesaurus Term: Asthma; Thesaurus Term: Health risk assessment; Thesaurus Term: Environmental health; Thesaurus Term: Epidemiology; Thesaurus Term: Genetics; Subject Term: Obesity; Subject Term: Medical sciences; Author-Supplied Keyword: asthma; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: genetics; Author-Supplied Keyword: hygiene hypothesis; Author-Supplied Keyword: incidence; Author-Supplied Keyword: obesity; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: smoking; Author-Supplied Keyword: susceptibility; Author-Supplied Keyword: windows of exposure and age (in utero, childhood, adult, elderly) ; Company/Entity: United States. Environmental Protection Agency; Reviews & Products: Environmental Health Perspectives (Periodical); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1289/ehp.8381
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20814567&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Schulte, Paul A.
T1 - Coal Tar and Paving Products.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/04//
VL - 114
IS - 4
M3 - Letter
SP - A210
EP - A210
PB - Superintendent of Documents
SN - 00916765
AB - A letter to the editor that responds to the article "Paving Paradise: The Peril of Impervious Surfaces," published in a 2006 issue is presented.
KW - Environmental health
KW - Letters to the editor
N1 - Accession Number: 20814510; Schulte, Paul A. 1; Email Address: pas4@cdc.gov; Affiliations: 1: Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Issue Info: Apr2006, Vol. 114 Issue 4, pA210; Thesaurus Term: Environmental health; Subject Term: Letters to the editor; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106148358
T1 - Workgroup report: review of genomics data based on experience with mock submissions -- view of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee.
AU - Leighton JK
AU - Brown P
AU - Ellis A
AU - Harlow P
AU - Harrouk W
AU - Pine PS
AU - Robison T
AU - Rosario L
AU - Thompson K
Y1 - 2006/04//
N1 - Accession Number: 106148358. Language: English. Entry Date: 20070907. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Genomics
KW - Pharmacy and Pharmacology
KW - Toxicology
KW - Animals
KW - Biochips
KW - Data Analysis Software
KW - Education
KW - Factor Analysis
KW - Management Information Systems
KW - Study Design
KW - Animal Studies
SP - 573
EP - 578
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 114
IS - 4
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - Over the past few years, both the U.S. Food and Drug Administration (FDA) and the pharmaceutical industry have recognized the potential importance of pharmacogenomics and toxicogenomics to drug development. To resolve the uncertainties surrounding the use of microarray technology and the presentation of genomics data for regulatory purposes, several pharmaceutical companies and genomics technology providers have provided the FDA with reports of genomics studies that included supporting toxicology data (e.g., serum chemistry, histopathology). These studies were not associated with any active drug application and were exploratory or hypothesis generating in nature. For training purposes, these reports were reviewed by the Nonclinical Pharmacogenomics Subcommittee consisting of the Center for Drug Evaluation and Research pharmacology and toxicology researchers and reviewers. In this article, we describe some of these submissions and report on our assessment of data content, format, and quality control metrics that were useful for evaluating these nonclinical genomics submissions, specifically in relation to the proposed MIAME/MINTox (minimum information about a microarray experiment/minimum information needed for a toxicology experiment) recommendations. These genomics submissions allowed both researchers and regulators to gain experience in the process of reviewing and analyzing toxicogenomics data. The experience will allow development of recommendations for the submission and review of these data as the state of the science evolves.
SN - 0091-6765
AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. leightonj@fda.hhs.gov
U2 - PMID: 16581548.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106148358&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zand, Debra
AU - Thomson, Nicole Renick
AU - Dugan, Mary
AU - Braun, James A.
AU - Holterman-Hommes, Pat
AU - Hunter, Patricia L.
T1 - PREDICTORS OF RETENTION IN AN ALCOHOL, TOBACCO, AND OTHER DRUG PREVENTION STUDY.
JO - Evaluation Review
JF - Evaluation Review
Y1 - 2006/04//
VL - 30
IS - 2
M3 - Article
SP - 209
EP - 222
SN - 0193841X
AB - This article explored retention patterns, as well as factors that predicted these patterns, in the evaluation of a relationship-based substance abuse prevention intervention study that targeted inner-city African American youth. A total of 851 contacts were made to retain 82% (n = 104) of the baseline sample (N = 127) in the evaluation. Results from multinomial regression analyses indicated that participants who were retained in the evaluation were more likely to perceive alcohol, tobacco, and other drug use as less risky and were more likely to report higher levels o f family supervision than were evaluation attrits. Those who were easy to retain reported lower family conflict and fewer family relocations during the past year than those who were difficult to retain. Implications of these findings for developing retention strategies, as well as future research, are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Evaluation Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEMORY
KW - DRUG abuse -- Treatment
KW - AFRICANS -- United States
KW - REGRESSION analysis
KW - ALCOHOL
KW - TOBACCO
KW - DRUGS
KW - FAMILY conflict
KW - UNITED States
KW - alcohol
KW - evaluation
KW - prevention
KW - retention
N1 - Accession Number: 20332603; Zand, Debra 1 Thomson, Nicole Renick 1 Dugan, Mary 2 Braun, James A. 3 Holterman-Hommes, Pat 4 Hunter, Patricia L.; Affiliation: 1: Research Assistant Professor, Missouri Institute of Mental Health, University of Missouri—Columbia 2: Evaluation Coordinator, Center for Substance Abuse Prevention, Missouri Institute of Mental Health, University of Missouri—Columbia 3: Chief Eexecutive Officer, Youth in Need Inc. 4: Senior Vice President, Youth Programs, Youth in Need Inc.; Source Info: Apr2006, Vol. 30 Issue 2, p209; Subject Term: MEMORY; Subject Term: DRUG abuse -- Treatment; Subject Term: AFRICANS -- United States; Subject Term: REGRESSION analysis; Subject Term: ALCOHOL; Subject Term: TOBACCO; Subject Term: DRUGS; Subject Term: FAMILY conflict; Subject Term: UNITED States; Author-Supplied Keyword: alcohol; Author-Supplied Keyword: evaluation; Author-Supplied Keyword: prevention; Author-Supplied Keyword: retention; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; Number of Pages: 14p; Document Type: Article
L3 - 10.1177/0193841X05281160
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20332603&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murlasits, Zsolt
AU - Cutlip, Robert G.
AU - Geronilla, Kenneth B.
AU - Rao, K. Murali K.
AU - Wonderlin, William F.
AU - Alway, Stephen E.
T1 - Resistance training increases heat shock protein levels in skeletal muscle of young and old rats
JO - Experimental Gerontology
JF - Experimental Gerontology
Y1 - 2006/04//
VL - 41
IS - 4
M3 - Article
SP - 398
EP - 406
SN - 05315565
AB - Abstract: Heat shock proteins (HSP) HSP72, HSC70 and HSP25 protein levels and mRNA levels of HSP72 genes (Hsp72−1, Hsp72-2, Hsp72−3) and HSC70 were examined in tibialis anterior muscles from young and old rats following 4.5 weeks of heavy resistance exercise. Young (3 months) (n=10) and old (30 months) (n=9) rats were subjected to 14 sessions of electrically evoked resistance training using stretch-shortening contractions of the left limb that activated the dorsiflexor muscle group, including the tibialis anterior muscle, while the right side served as the intra-animal control. Muscle wet weight of the left tibialis anterior increased by 15.6% in young animals compared to the untrained right side, while the aged rats demonstrated no significant hypertrophy based on muscle wet weight. There were no differences in mRNA expression between the control and experimental muscles in either the old or the young animals for any of the four genes examined. On the other hand, HSP72 levels as determined by Western blots were significantly (p<0.01) higher (968.8 and 409.1%) in the trained as compared to the contralateral control muscle in young and old animals, respectively. HSP25 expression was increased significantly (p<0.01) by training in muscles of young rats (943.1%) and old rats (420.3%). Moreover, there was no training by age interaction for HSP72, while a significant age and training by age effects were found in muscles for HSP25. There was no change in HSC70 protein expression in response to the training intervention in either age group. SOD-1 enzyme level increased by 66.6% in the trained muscles of the young rats, while this enzyme was 33% lower in trained muscles compared to the untrained control side in old rats. Moreover, a significant (p<0.05) training by age interaction was found for SOD-1 enzyme levels. This study suggests that fast contracting muscles in young and old animals are capable of increasing HSP expression in response to high intensity contractile stress. Furthermore, the data are consistent with the hypothesis that higher levels of oxidative stress in muscles of old animals limit HSP levels and/or function in response to high intensity contractile stress. [Copyright &y& Elsevier]
AB - Copyright of Experimental Gerontology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEIGHT training
KW - HEAT shock proteins
KW - MUSCLES
KW - MESSENGER RNA
KW - Aging
KW - Chaperone proteins
KW - Exercise
KW - Oxidative stress
KW - Stress proteins
N1 - Accession Number: 20730750; Murlasits, Zsolt 1 Cutlip, Robert G. 2 Geronilla, Kenneth B. 2 Rao, K. Murali K. 2 Wonderlin, William F. 3 Alway, Stephen E. 1; Email Address: salway@hsc.wvu.edu; Affiliation: 1: Division of Exercise Physiology, Laboratory of Muscle Biology and Sarcopenia, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506-9227, USA 2: Division National Institute for Occupational Safety and Health, Health Effects Laboratory, Morgantown, WV 26505, USA 3: Department of Biochemistry and Molecular Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, USA; Source Info: Apr2006, Vol. 41 Issue 4, p398; Subject Term: WEIGHT training; Subject Term: HEAT shock proteins; Subject Term: MUSCLES; Subject Term: MESSENGER RNA; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Chaperone proteins; Author-Supplied Keyword: Exercise; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Stress proteins; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.exger.2006.01.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20730750&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sriram, Krishnan
AU - Matheson, Joanna M.
AU - Benkovic, Stanley A.
AU - Miller, Diane B.
AU - Luster, Michael I.
AU - O'Callaghan, James P.
T1 - Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-α.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2006/04//
VL - 20
IS - 6
M3 - Article
SP - 670
EP - 682
AB - Enhanced expression of tumor necrosis factor (TNF) -α, is associated with the neuropathological effects underlying disease-, trauma- and chemically induced neurodegeneration. Previously, we have shown that deficiency of TNF receptors protects against MPTP-induced striatal dopaminergic neurotoxicity, findings suggestive of a role for TNF-α in neurodegeneration. Here, we demonstrate that deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP. MPTP-induced expression of microglia-derived factors, TNF-α, MCP-1, and IL-1α, preceded the degeneration of striatal dopaminergic nerve terminals and astrogliosis, as assessed by loss of striatal dopamine and TH, and an increase in striatal GFAP. Pharmacological neuroprotection with the dopamine reuptake inhibitor, nomifensine, abolished striatal dopaminergic neurotoxicity and associated microglial activation. Similarly, in mice lacking TNF receptors, microglial activation was suppressed, findings consistent with a role for TNF-α in striatal MPTP neurotoxicity. In the hippocampus, however, TNF receptor-deficient mice showed exacerbated neuronal damage after MPTP, as evidenced by Fluoro Jade-B staining (to identify degenerating neurons) and decreased microtubule-associated protein-2 (MAP-2) immunoreactivity. These effects were not accompanied by microglial activation, but were associated with increased oxidative stress (nitrosylation of tyrosine residues). These findings suggest that TNF-α exerts a neurotrophic/neuroprotective effect in hippocampus. The marked differences we observed in the regional density, distribution and/or activity of microglia and microglia-derived factors may influence the region-specific role for this cell type. Taken together, our results are indicative of a region-specific and dual role for TNF-α in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIPPOCAMPUS (Brain)
KW - TUMOR necrosis factor
KW - NERVOUS system -- Diseases
KW - NEUROGLIA
KW - DOPAMINE
KW - NEUROTRANSMITTERS
KW - CATECHOLAMINES
KW - CYTOKINES
KW - brain
KW - microglia
KW - neurodegeneration
KW - neuroinflammation
KW - neuroprotection
N1 - Accession Number: 20862907; Sriram, Krishnan 1 Matheson, Joanna M. 1 Benkovic, Stanley A. 1 Miller, Diane B. 1 Luster, Michael I. 1 O'Callaghan, James P. 1; Email Address: jdo5@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Apr2006, Vol. 20 Issue 6, p670; Subject Term: HIPPOCAMPUS (Brain); Subject Term: TUMOR necrosis factor; Subject Term: NERVOUS system -- Diseases; Subject Term: NEUROGLIA; Subject Term: DOPAMINE; Subject Term: NEUROTRANSMITTERS; Subject Term: CATECHOLAMINES; Subject Term: CYTOKINES; Author-Supplied Keyword: brain; Author-Supplied Keyword: microglia; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: neuroinflammation; Author-Supplied Keyword: neuroprotection; Number of Pages: 13p; Illustrations: 6 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1096/fj.05-5106com
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20862907&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wiesenfeld, P.W.
AU - Sapienza, P.P.
AU - Flynn, T.J.
AU - Ford, C.E.
AU - Ross, I.A.
AU - Sahu, S.
AU - Kim, C.S.
AU - O’Donnell, M.W.
AU - Collins, T.F.X.
AU - Sprando, R.L.
T1 - Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E2 and C-reactive protein in serum and livers of pregnant and non-pregnant female rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/04//
VL - 44
IS - 4
M3 - Article
SP - 579
EP - 587
SN - 02786915
AB - Abstract: Androstenedione, a steroidal dietary supplement taken to enhance athletic performance, could affect serum and liver lipid metabolism, induce liver toxicity or alter inflammatory response depending on dose and duration of exposure. Pregnancy could further exaggerate these effects. To examine this, mature female rats were gavaged with 0, 5, 30 or 60mg/kg/day androstenedione beginning two weeks prior to mating and continuing through gestation day 19. Non-pregnant female rats were gavaged over the same time frame with 0 or 60mg/kg/day androstenedione. Serum was collected and livers were removed from dams on gestation day 20 and from non-pregnant rats after 5 weeks of treatment. Androstenedione had no effect on serum total cholesterol, triglycerides or HDL-cholesterol, but significantly decreased C-reactive protein in pregnant rats and prostaglandin E2 in serum of both pregnant and non-pregnant rats. There were treatment related decreases in liver ATP and, to a lesser degree, caspase-3 and no change in alkaline phosphatase of pregnant female rats. Androstenedione decreased docosahexaenoic acid in both serum and liver phospholipids of pregnant female rats. In conclusion, oral androstenedione did not result in overt hepatotoxicity in pregnant female rats, but produced modest changes in lipid metabolism and may impair regeneration of injured hepatic cells or tissue. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROSTENEDIONE
KW - ANABOLIC steroids
KW - HEPATOTOXICOLOGY
KW - LIVER diseases
KW - TOXICOLOGY
KW - (AA, C20:4) ( arachidonic acid )
KW - (C16:0) ( palmitic acid )
KW - (C18:1) ( oleic acid )
KW - (C18:1t) ( elaidic acid )
KW - (C18:2) ( linoleic acid )
KW - (C18:3) ( linolenic acid )
KW - (C20:3) ( eicosatrienoic acid )
KW - (C22:3) ( docosatrienoic acid )
KW - (CRP) ( C-reactive protein )
KW - (DHA, C22:6) ( docosahexaenoic acid )
KW - (HDL) ( high density lipoprotein )
KW - (LDL) ( low density lipoprotein )
KW - (PGE2) ( prostaglandin E2 )
KW - (VLDL) ( very low density lipoprotein )
KW - Androstenedione
KW - C-reactive protein
KW - docosadienoic acid (C22:2)
KW - Fatty acids
KW - Liver
KW - Pregnant
KW - Prostaglandin E2
KW - Rats
N1 - Accession Number: 20013598; Wiesenfeld, P.W. 1; Email Address: pwiesenf@cfsan.fda.gov Sapienza, P.P. 1 Flynn, T.J. 1 Ford, C.E. 1 Ross, I.A. 1 Sahu, S. 1 Kim, C.S. 1 O’Donnell, M.W. 2 Collins, T.F.X. 1 Sprando, R.L. 1; Affiliation: 1: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: US FDA, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, MD 20708, USA; Source Info: Apr2006, Vol. 44 Issue 4, p579; Subject Term: ANDROSTENEDIONE; Subject Term: ANABOLIC steroids; Subject Term: HEPATOTOXICOLOGY; Subject Term: LIVER diseases; Subject Term: TOXICOLOGY; Author-Supplied Keyword: (AA, C20:4) ( arachidonic acid ); Author-Supplied Keyword: (C16:0) ( palmitic acid ); Author-Supplied Keyword: (C18:1) ( oleic acid ); Author-Supplied Keyword: (C18:1t) ( elaidic acid ); Author-Supplied Keyword: (C18:2) ( linoleic acid ); Author-Supplied Keyword: (C18:3) ( linolenic acid ); Author-Supplied Keyword: (C20:3) ( eicosatrienoic acid ); Author-Supplied Keyword: (C22:3) ( docosatrienoic acid ); Author-Supplied Keyword: (CRP) ( C-reactive protein ); Author-Supplied Keyword: (DHA, C22:6) ( docosahexaenoic acid ); Author-Supplied Keyword: (HDL) ( high density lipoprotein ); Author-Supplied Keyword: (LDL) ( low density lipoprotein ); Author-Supplied Keyword: (PGE2) ( prostaglandin E2 ); Author-Supplied Keyword: (VLDL) ( very low density lipoprotein ); Author-Supplied Keyword: Androstenedione; Author-Supplied Keyword: C-reactive protein; Author-Supplied Keyword: docosadienoic acid (C22:2); Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Pregnant; Author-Supplied Keyword: Prostaglandin E2; Author-Supplied Keyword: Rats; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2005.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20013598&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Katano, H.
AU - Kok, M. R.
AU - Cotrim, A. P.
AU - Yamano, S.
AU - Schmidt, M.
AU - Afione, S.
AU - Baum, B. J.
AU - Chiorini, J. A.
T1 - Enhanced transduction of mouse salivary glands with AAV5-based vectors.
JO - Gene Therapy
JF - Gene Therapy
Y1 - 2006/04//
VL - 13
IS - 7
M3 - Article
SP - 594
EP - 601
PB - Nature Publishing Group
SN - 09697128
AB - We previously demonstrated that recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells in vitro and in vivo. However, it is not known how other rAAV serotypes perform when infused into salivary glands. The capsids of serotypes 4 and 5 are distinct from rAAV2 and from each other, suggesting that they may direct binding and entry into different cell types. In the present study, we investigated the tropisms, transduction efficiencies, and antibody response to AAV vectors based on AAV serotypes 2, 4, and 5. Administration of rAAV2β-galactosidase (βgal), rAAV4βgal, or rAAV5βgal to murine submandibular salivary glands by retrograde ductal instillation resulted in efficient transduction of salivary epithelial cells, with AAV4 and AAV5 producing 2.3 and 7.3 times more βgal activity compared with AAV2. Improved transduction with AAV5 was confirmed by QPCR of DNA extracted from glands and immunohistochemical staining for transgene expression. Like AAV2, AAV5 primarily transduced striated and intercalated ductal cells. AAV4 transduction was evident in striated, intercalated, and excretory ductal cells, as well as in convoluted granular tubules. In keeping with the encapsulated nature of the salivary gland, the majority of persistent viral genomes were found in the gland and not in other tissues. Neutralizing antibodies (NABs) found in the serum of virus-infused animals were serotype specific and there was no crossreactivity between serotypes. No NABs were detected in saliva but sialic acid conjugates present in saliva could neutralize AAV4 at low dilutions. Together our data suggest that because of differences in receptor binding and transduction pathways, other serotypes may have improved utility as gene transfer vectors in the salivary gland and these differences could be exploited in gene therapy applications.Gene Therapy (2006) 13, 594–601. doi:10.1038/sj.gt.3302691; published online 8 December 2005 [ABSTRACT FROM AUTHOR]
AB - Copyright of Gene Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALIVARY glands
KW - TRANSGENES -- Expression
KW - RECOMBINANT viruses
KW - CANCER -- Gene therapy
KW - CANCER genetics
KW - AAV
KW - adeno-associated virus
KW - mice
KW - salivary glands
KW - serotype
N1 - Accession Number: 20198401; Katano, H. 1 Kok, M. R. 1 Cotrim, A. P. 1 Yamano, S. 1 Schmidt, M. 1 Afione, S. 1 Baum, B. J. 1 Chiorini, J. A. 1; Email Address: jchiorini@dir.nidcr.nih.gov; Affiliation: 1: Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA; Source Info: Apr2006, Vol. 13 Issue 7, p594; Subject Term: SALIVARY glands; Subject Term: TRANSGENES -- Expression; Subject Term: RECOMBINANT viruses; Subject Term: CANCER -- Gene therapy; Subject Term: CANCER genetics; Author-Supplied Keyword: AAV; Author-Supplied Keyword: adeno-associated virus; Author-Supplied Keyword: mice; Author-Supplied Keyword: salivary glands; Author-Supplied Keyword: serotype; Number of Pages: 8p; Illustrations: 1 Color Photograph, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1038/sj.gt.3302691
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20198401&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Han, Jing
AU - Farnsworth, Richard L.
AU - Tiwari, Jawahar L.
AU - Tian, Jie
AU - Lee, Hin
AU - Ikonomi, Pranvera
AU - Byrnes, Andrew P.
AU - Goodman, Jesse L.
AU - Puri, Raj K.
T1 - Quality prediction of cell substrate using gene expression profiling
JO - Genomics
JF - Genomics
Y1 - 2006/04//
VL - 87
IS - 4
M3 - Article
SP - 552
EP - 559
SN - 08887543
AB - Abstract: Changes in cell culture conditions influence the metabolism of cells, which consequently affects the quality of the products that they produce, such as viral vectors, recombinant proteins, or vaccines. Currently there is no effective technique available to monitor global quality of cells in cell culture. Here we describe a new method using gene expression profiling by microarray to predict the quality of cell substrates. Human embryonic kidney 293 cells are a commonly used cell substrate in the production of biological products. We demonstrate that the yield of adenoviral vectors was lower in over-confluent 293 cells, compared to 40 or 90% confluent cells. Total RNA derived from these cells of different confluence states was reverse transcribed, labeled, and used to hybridize 10K cDNA arrays to determine biomarkers for confluence states. Phenotype scatter-plot analysis and cluster analysis were used for class discovery. Based on this approach, we identified genes that were either up-regulated or down-modulated in response to different cell confluence states. By multivariate predictive models we identified a set of 37 genes that were either down-regulated or up-regulated compared to 90% confluent cells as a predictor of cell confluence and quality of 293 cell cultures. The predictive accuracy of these models was assessed by the leave-one-out cross-validation method. The expression of selected gene predictors was validated by quantitative PCR analysis. Our results demonstrate that gene expression profiling can assess the quality of cell substrates prior to large-scale production of a biological product. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL culture
KW - DNA microarrays
KW - GENE expression
KW - POLYMERASE chain reaction
KW - 293 cells
KW - cell confluence
KW - class prediction
KW - class prediction, Real-time PCR
KW - DNA microarray
KW - gene expression profile
KW - Real-time PCR
N1 - Accession Number: 20252651; Han, Jing 1 Farnsworth, Richard L. 2 Tiwari, Jawahar L. 3 Tian, Jie 4 Lee, Hin 1 Ikonomi, Pranvera 2 Byrnes, Andrew P. 4 Goodman, Jesse L. 1 Puri, Raj K. 1; Email Address: puri@cber.fda.gov; Affiliation: 1: Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 2NN20, 29 Lincoln Drive, Bethesda, MD 20892, USA 2: American Type Culture Collection, Manassas, VA 20110, USA 3: Division of Biostatistics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 4: Laboratory of Immunology and Virology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2006, Vol. 87 Issue 4, p552; Subject Term: CELL culture; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: 293 cells; Author-Supplied Keyword: cell confluence; Author-Supplied Keyword: class prediction; Author-Supplied Keyword: class prediction, Real-time PCR; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: gene expression profile; Author-Supplied Keyword: Real-time PCR; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ygeno.2005.11.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20252651&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McDermott, M.
AU - Isayeva, I.
AU - Thomas, T.
AU - Lee, A.
AU - Lucas, A.
AU - Witkowski, C.
AU - Hutter, J.
T1 - Characterization of the structure and properties of authentic and counterfeit polypropylene surgical meshes.
JO - Hernia
JF - Hernia
Y1 - 2006/04//
VL - 10
IS - 2
M3 - Article
SP - 131
EP - 142
SN - 12654906
AB - A counterfeit version of the Ethicon Prolene polypropylene mesh was distributed to hospitals and clinics and unintentionally implanted into patients undergoing tension-free hernia repair. On December 19, , the Food and Drug Administration (FDA) issued a public health web notification indicating that the counterfeit mesh was not sterile or safe to use. To develop safety recommendations for patients with the counterfeit mesh implant, we compared the counterfeit’s structural, physical, chemical and mechanical properties with polypropylene meshes previously cleared by FDA. The mesh fibers for all the products tested were found to have similar chemical and physical properties. The mechanical properties were directly related to the knitted structure (loop size, repeat distance, fabric tightness) and the porosity. Extracts from the counterfeit mesh passed cytotoxicity screening tests. The FDA further recommended that if the mesh had been inadvertently implanted, then those patients should be monitored as would be the practice for any patient with an implanted surgical mesh. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hernia is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURGICAL dressings
KW - PRODUCT counterfeiting
KW - HERNIA -- Surgery
KW - HOSPITALS
KW - PUBLIC health
KW - Biocompatibility
KW - Elasticity
KW - Hernia repair
KW - Mesh properties
KW - Mesh repair
N1 - Accession Number: 20457410; McDermott, M. 1; Email Address: martin.mcdermott@fda.hhs.gov Isayeva, I. 1 Thomas, T. 1 Lee, A. 1 Lucas, A. 1 Witkowski, C. 1 Hutter, J. 1; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories , 12725 Twinbrook Parkway, HFZ-150 Rockville 20852, USA; Source Info: Apr2006, Vol. 10 Issue 2, p131; Subject Term: SURGICAL dressings; Subject Term: PRODUCT counterfeiting; Subject Term: HERNIA -- Surgery; Subject Term: HOSPITALS; Subject Term: PUBLIC health; Author-Supplied Keyword: Biocompatibility; Author-Supplied Keyword: Elasticity; Author-Supplied Keyword: Hernia repair; Author-Supplied Keyword: Mesh properties; Author-Supplied Keyword: Mesh repair; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Document Type: Article
L3 - 10.1007/s10029-005-0042-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20457410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106304049
T1 - Suggestions for preventing musculoskeletal disorders in home healthcare workers. Part 2: lift and transfer assistance for non-weight-bearing home care patients...Second article in a two-part series
AU - Parsons KS
AU - Galinsky TL
AU - Waters T
Y1 - 2006/04//
N1 - Accession Number: 106304049. Language: English. Entry Date: 20060714. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8403379.
KW - Hoists
KW - Musculoskeletal Diseases -- Prevention and Control
KW - Occupational-Related Injuries -- Prevention and Control
KW - Beds and Mattresses
KW - Education, Continuing (Credit)
KW - Ergonomics
KW - Home Health Care
KW - Lifting and Transfer Equipment
KW - Portable Equipment
SP - 227
EP - 235
JO - Home Healthcare Nurse
JF - Home Healthcare Nurse
JA - HOME HEALTHC NURSE
VL - 24
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Home healthcare (HHC) is one of the fastest-growing professions, currently employing more than 1 million workers in the United States. Unfortunately, these workers sustain an exceptionally high rate of musculoskeletal disorders. This is the second article in a two-part series providing information and suggestions for preventing overexertion that can lead to such disorders.
SN - 0884-741X
AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. kparsons@cdc.gov
U2 - PMID: 16680053.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106304049&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rui Qiang
AU - Dagang Wu
AU - Ji Chen
AU - Shumin Wang
AU - Wilton, Donald
AU - Wolfgang Kainz
T1 - An Efficient Two-Dimensional FDTD Method for Bio-Electromagnetic Applications.
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
Y1 - 2006/04//
VL - 42
IS - 4
M3 - Article
SP - 1391
EP - 1394
SN - 00189464
AB - We propose an efficient algorithm for the simulation of densely sampled biological objects. This technique is based on an algebraic multi-grid (AMG) accelerated Crank-Nicholson (CN) finite-difference time-domain (FDTD) method. Using this scheme, simulation time step sizes are no longer limited by the Courant-Friedrich-Levy (CFL) number. A practical guideline on how to choose appropriate time-step sizes for accurate bioelectromagnetic applications is also presented. Numerical examples are used to demonstrate the effectiveness of this technique. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Magnetics is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FINITE differences
KW - ELECTRODYNAMICS
KW - NUMERICAL analysis
KW - ALGORITHMS
KW - TIME-domain analysis
KW - MEDICAL electronics
KW - Algebraic multi-grid method
KW - bio-electromagnetics
KW - FDTD method
KW - unconditionally stable. algorithm.
N1 - Accession Number: 20835161; Rui Qiang 1 Dagang Wu 1 Ji Chen 1; Email Address: jchen18@uh.edu Shumin Wang 2 Wilton, Donald 1 Wolfgang Kainz 3; Affiliation: 1: Department of Electrical and Computer Engineering, University of Houston, Houston, TX, 77204 USA. 2: National Institutes of Health, Bethesda, MD 20892 USA. 3: U.S. Food and Drug Administration, Center for Devices and Radiological Health (CDRH), Rockville, MD 20852 USA.; Source Info: Apr2006, Vol. 42 Issue 4, p1391; Subject Term: FINITE differences; Subject Term: ELECTRODYNAMICS; Subject Term: NUMERICAL analysis; Subject Term: ALGORITHMS; Subject Term: TIME-domain analysis; Subject Term: MEDICAL electronics; Author-Supplied Keyword: Algebraic multi-grid method; Author-Supplied Keyword: bio-electromagnetics; Author-Supplied Keyword: FDTD method; Author-Supplied Keyword: unconditionally stable. algorithm.; Number of Pages: 4p; Document Type: Article
L3 - 10.1109/TMAG.2006.871947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20835161&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malkin, Robert
AU - Lentz, Thomas J.
AU - Topmiller, Jennifer
AU - Hudock, Stephen D.
AU - Niemeier, Richard W.
T1 - The Characterization of Airborne Occupational Safety and Health Hazards in Selected Small Business; Manufacturing Wood Pallets.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/04//
VL - 44
IS - 2
M3 - Article
SP - 58
EP - 63
SN - 00198366
AB - The article provides an overview of measured exposures to airborne particulate and carbon monoxide in the wood pallet manufacturing industry. A list of the occupational safety and health administration standards is presented. Total airborne dust was measured using a real-time light scattering photometer.
KW - Industrial safety
KW - Industrial hygiene
KW - Carbon monoxide
KW - Pallet industry
KW - Small business
KW - CO
KW - Ergonomics
KW - Forklifts
KW - Noise
KW - Pallets
KW - Saws
KW - Ventilation
KW - Wood
N1 - Accession Number: 22397806; Malkin, Robert 1; Lentz, Thomas J. 1; Topmiller, Jennifer 2; Hudock, Stephen D. 2; Niemeier, Richard W. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Education and Information Division, USA; 2: National Institute for Occupational Safety and Health, Division of Applied Research Technology, USA; Issue Info: 2006, Vol. 44 Issue 2, p58; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial hygiene; Thesaurus Term: Carbon monoxide; Subject Term: Pallet industry; Subject Term: Small business; Author-Supplied Keyword: CO; Author-Supplied Keyword: Ergonomics; Author-Supplied Keyword: Forklifts; Author-Supplied Keyword: Noise; Author-Supplied Keyword: Pallets; Author-Supplied Keyword: Saws; Author-Supplied Keyword: Ventilation; Author-Supplied Keyword: Wood; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 321920 Wood Container and Pallet Manufacturing; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kubo, Nobuako
AU - Usami, Takahiro
AU - Haruyama, Yasuo
AU - Muto, Takashi
AU - Kimura, Kazumoto
AU - Yukawa, Satoru
AU - Kimura, Takayuki
AU - Yamane, Noriyuki
T1 - Characteristics of Lifestyle and Health Status of Workers in Small-Scale Enterprises in Japan.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/04//
VL - 44
IS - 2
M3 - Article
SP - 161
EP - 165
SN - 00198366
AB - The characteristics of lifestyle and health status of workers in small-scale enterprises in Japan is clarified. Frequencies of abnormal lifestyle and health check-up data were described according to the category of the enterprise. The odds ratio of audiometry, hypertension, glucose in urine and electrocardiography in male and female respondents were higher in small-scale enterprises.
KW - Industrial hygiene
KW - Health
KW - Small business
KW - Lifestyles
KW - Japan
KW - Health check-up
KW - Health status
KW - Lifestyle
KW - Occupational heath
KW - Size of enterprise
KW - Small-scale Enterprises
N1 - Accession Number: 22397824; Kubo, Nobuako 1; Usami, Takahiro 1; Haruyama, Yasuo 1; Muto, Takashi 1; Kimura, Kazumoto 2; Yukawa, Satoru 3; Kimura, Takayuki 3; Yamane, Noriyuki 3; Affiliations: 1: Department of Public Health Science, Dokkyo University School of Medicine, Tochigi, Japan; 2: Center of Medical Informatics, Dokkyo University School of Medicine, Mibu, Japan; 3: Tochigi Public Health Service Association, Utsumomiya, Japan; Issue Info: 2006, Vol. 44 Issue 2, p161; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health; Subject Term: Small business; Subject Term: Lifestyles; Subject: Japan; Author-Supplied Keyword: Health check-up; Author-Supplied Keyword: Health status; Author-Supplied Keyword: Lifestyle; Author-Supplied Keyword: Occupational heath; Author-Supplied Keyword: Size of enterprise; Author-Supplied Keyword: Small-scale Enterprises; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lavicoli, Sergio
AU - Rondinone, Bruna
AU - Marinaccio, Alessandro
AU - Fingerhut, Marilyn
T1 - Research Priorities in Occupational Safety and Health: A Review.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/04//
VL - 44
IS - 2
M3 - Article
SP - 169
EP - 178
SN - 00198366
AB - The article presents a comparative analysis of the main projects to identify research priorities in the occupational safety and health field. It has been showed how important it is to reach consensus among all those operating in the occupational safety and health sector in order to establish standard methods that can be applied in different contexts.
KW - Industrial safety
KW - Health
KW - Comparative studies
KW - Industrial hygiene
KW - Work environment
KW - Consensus
KW - Delphi technique
KW - OSH
KW - Research Priorities
KW - Stakeholders
N1 - Accession Number: 22397826; Lavicoli, Sergio 1; Rondinone, Bruna 1; Marinaccio, Alessandro 2; Fingerhut, Marilyn 3; Affiliations: 1: ISPESL National Institute for Occupational Safety and Prevention, Via Fontana Candida, Rome, Italy; 2: ISPESL National Institute for Occupational Safety and Prevention, Rome, Italy; 3: NIOSH National Institute for Occupational Safety and Health, Washington DC, USA; Issue Info: 2006, Vol. 44 Issue 2, p169; Thesaurus Term: Industrial safety; Thesaurus Term: Health; Thesaurus Term: Comparative studies; Thesaurus Term: Industrial hygiene; Subject Term: Work environment; Author-Supplied Keyword: Consensus; Author-Supplied Keyword: Delphi technique; Author-Supplied Keyword: OSH; Author-Supplied Keyword: Research Priorities; Author-Supplied Keyword: Stakeholders; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Araki, Shunichi
T1 - Promotion of Occupational Health and Safety Research: Foundation of a New Independent Administrative Institution in Japan.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/04//
VL - 44
IS - 2
M3 - Article
SP - 215
EP - 217
SN - 00198366
AB - The article highlights the National Conference on Promotion of Occupational Health Research Priorities which was organized by the National Institute of Industrial Health in 2001 and has been supported by the Japan Ministry of Health, Labor and Welfare. The purpose of the activity is to promote occupational health in Japan.
KW - Industrial hygiene
KW - Industrial safety
KW - Health
KW - Conferences & conventions
KW - Japan
N1 - Accession Number: 22397832; Araki, Shunichi 1; Affiliations: 1: National Institute of Occupational Safety and Health, Japan, and Professor Emeritus, The University of Tokyo; Issue Info: 2006, Vol. 44 Issue 2, p215; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Health; Subject Term: Conferences & conventions; Subject: Japan; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106303690
T1 - High caffeine intake in adolescents: associations with difficulty sleeping and feeling tired in the morning.
AU - Orbeta RL
AU - Overpeck MD
AU - Ramcharran D
AU - Kogan MD
AU - Ledsky R
Y1 - 2006/04//
N1 - Accession Number: 106303690. Language: English. Entry Date: 20060714. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 9102136.
KW - Caffeine -- Adverse Effects -- In Adolescence
KW - Sleep Disorders -- In Adolescence
KW - Adolescence
KW - Beverages
KW - Bivariate Statistics
KW - Confidence Intervals
KW - Correlational Studies
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - Questionnaires
KW - Schools
KW - Survey Research
KW - United States
KW - Univariate Statistics
KW - Human
SP - 451
EP - 453
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
JA - J ADOLESC HEALTH
VL - 38
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - The objective of this study was to examine the association between caffeine usage in U.S. adolescents and the frequency that feeling tired in the morning and having difficulty sleeping is reported. In this study we found that feeling tired in the morning and having difficulty sleeping was experienced more commonly in those adolescents that have a high intake of caffeine.
SN - 1054-139X
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland 20857, USA. btingle76@yahoo.com
U2 - PMID: 16549311.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ku, Bon Ki
AU - Maynard, Andrew D.
T1 - Generation and investigation of airborne silver nanoparticles with specific size and morphology by homogeneous nucleation, coagulation and sintering
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2006/04//
VL - 37
IS - 4
M3 - Article
SP - 452
EP - 470
SN - 00218502
AB - Abstract: An aerosol generation facility has been characterized to produce well-defined silver nanoparticles for use as a test aerosol when evaluating instrument response to different particle morphologies within a range of sizes. The generator consists of two in-series laminar tube furnaces to produce and subsequently sinter particles, and is capable of generating spherical or agglomerated fractal-like silver particles, with corresponding projected surface (two-dimensional) fractal dimensions from 1.58 to 1.94. The morphologies of generated particles as well as size distributions at different sintering temperatures were characterized using a transmission electron microscope (TEM) and a scanning mobility particle sizer (SMPS). Mean diameters measured were significantly reduced for sintering temperatures from 100 to , but showed little variation for sintering temperatures above . TEM analysis indicated that this phenomenon was caused by sintering, followed by partial and complete coalescence of fractal-like agglomerates into spheres. Agglomerate restructuring from classical completely sintered agglomerates to spherical particles did not lead to a change in the particle mobility size distribution. The temperature at which complete sintering occurred was higher than that predicted by theory, but was in reasonable agreement with previously published experimental data. For monodisperse particles in the size range from 20 to 100nm, a simple exponential model related sintering temperature to the diameter of coalesced spherical particles. [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILVER
KW - NANOPARTICLES
KW - NUCLEATION
KW - SINTERING
KW - Coalescence
KW - Morphology
KW - Silver nanoparticles
KW - Sintering
KW - Tube furnace
N1 - Accession Number: 20556294; Ku, Bon Ki; Email Address: bik5@cdc.gov Maynard, Andrew D. 1; Affiliation: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA; Source Info: Apr2006, Vol. 37 Issue 4, p452; Subject Term: SILVER; Subject Term: NANOPARTICLES; Subject Term: NUCLEATION; Subject Term: SINTERING; Author-Supplied Keyword: Coalescence; Author-Supplied Keyword: Morphology; Author-Supplied Keyword: Silver nanoparticles; Author-Supplied Keyword: Sintering; Author-Supplied Keyword: Tube furnace; NAICS/Industry Codes: 212210 Iron Ore Mining; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.jaerosci.2005.05.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Acute vibration increases α2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries.
AU - Krajnak, K.
AU - Dong, R. G.
AU - Flavahan, S.
AU - Welcome, D.
AU - Flavahan, N. A.
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
Y1 - 2006/04//
VL - 100
IS - 4
SP - 1230
EP - 1237
SN - 87507587
N1 - Accession Number: 20572615; Author: Krajnak, K.: 1 Author: Dong, R. G.: 1 Author: Flavahan, S.: 2 Author: Welcome, D.: 1 Author: Flavahan, N. A.: 1 email: nicholas-flavahan@osumc.edu. ; Author Affiliation: 1 National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Engineering and Control Technology Branch, Morgantown, West Virginia: 2 Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20060425
N2 - The vascular symptoms of hand-arm vibration syndrome, including cold-induced vasospasm, are in part mediated by increased sensitivity of cutaneous arteries to sympathetic stimulation. The goal of the present study was to use a rat tail model to analyze the effects of vibration on vascular function and α-adrenoceptor (AR) responsiveness. Rats were exposed to a single period of vibration (4 h, 125 Hz, constant acceleration 49 m/s² root mean square). The physical or biodynamic response of the tail demonstrated increased transmissibility or resonance at this frequency, similar to that observed during vibration of human fingers. Morphological analysis demonstrated that vibration did not appear to cause structural injury to vascular cells. In vitro analysis of vascular function demonstrated that constriction to the α1-AR agonist phenylephrine was similar in vibrated and control arteries. In contrast, constriction to the α2-AR agonist UK14304 was increased in vibrated compared with control arteries, both in endothelium-containing or endothelium-denuded arteries. The α2C-AR antagonist MK912 (3 × 10-10 M) inhibited constriction to UK14304 in vibrated but not control arteries, reversing the vibration-induced increase in α2-AR activity. Moderate cooling (to 28°C) increased constriction to the α2-AR agonist in control and vibrated arteries, but the magnitude of the amplification was less in vibrated compared with control arteries. Endothelium-dependent relaxation to acetylcholine was similar in control and vibrated arteries. Based on these results, we conclude that a single exposure to vibration caused a persistent increase in α2C-AR-mediated vasoconstriction, which may contribute to the pathogenesis of vibration-induced vascular disease. ABSTRACT FROM AUTHOR
KW - *VASCULAR diseases
KW - *CARDIOVASCULAR diseases
KW - *ARTERIES
KW - *SMOOTH muscle
KW - *MORPHOLOGY
KW - VIBRATION syndrome
KW - cold
KW - hand-arm vibration syndrome
KW - rat tail artery
KW - Raynaud's phenomenon
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Pagán-Ramos, Eileen
AU - Master, Sharon S.
AU - Pritchett, Christopher L.
AU - Reimschuessel, Renate
AU - Trucksis, Michele
AU - Timmins, Graham S.
AU - Deretic, Vojo
T1 - Molecular and Physiological Effects of Mycobacterial oxyR Inactivation.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2006/04//
VL - 188
IS - 7
M3 - Article
SP - 5
EP - 5
SN - 00219193
AB - The majority of slow-growing mycobacteria have a functional oxyR, the central regulator of the bacterial oxidative stress response. In contrast, this gene has been inactivated during the evolution of Mycobacterium tuberculosis. Here we inactivated the oxyR gene in Mycobacterium marinum, an organism used to model M. tuberculosis pathogenesis. Inactivation of oxyR abrogated induction of ahpC, a gene encoding alkylhydroperoxide reductase, normally activated upon peroxide challenge. The absence of oxyR also resulted in increased sensitivity to the front-line antituberculosis drug isoniazid. Inactivation of oxyR in M. marinum did not affect either virulence in a fish infection model or survival in human macrophages. Our findings demonstrate, at the genetic and molecular levels, a direct role for OxyR in ahpC regulation in response to oxidative stress. Our study also indicates that oxyR is not critical for virulence in M. marinum. However, oxyR inactivation confers increased sensitivity to isonicotinic acid hydrazide, suggesting that the natural loss of oxyR in the tubercle bacillus contributes to the unusually high sensitivity of M. tuberculosis to isoniazid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM
KW - GENETIC regulation
KW - OXIDATIVE stress
KW - OXIDATION-reduction reaction
KW - TUBERCULOSIS
KW - MACROPHAGES
KW - MYCOBACTERIUM marinum
N1 - Accession Number: 20729189; Pagán-Ramos, Eileen 1 Master, Sharon S. 2 Pritchett, Christopher L. 3 Reimschuessel, Renate 4 Trucksis, Michele 5 Timmins, Graham S. 6; Email Address: gtimmins@salud.unm.edu Deretic, Vojo 7; Affiliation: 1: Department of Microbiology, University of Michigan Medical School, Ann Arbor, Michigan 48105 2: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 3: Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201 4: Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland 20857 5: Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 6: School of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 7: Department of Molecular Genetics and Microbiology, Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131; Source Info: Apr2006, Vol. 188 Issue 7, p5; Subject Term: MYCOBACTERIUM; Subject Term: GENETIC regulation; Subject Term: OXIDATIVE stress; Subject Term: OXIDATION-reduction reaction; Subject Term: TUBERCULOSIS; Subject Term: MACROPHAGES; Subject Term: MYCOBACTERIUM marinum; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.188.7.2674-2680.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bi, Yongyi
AU - Lin, Gary X.
AU - Millecchia, Lyndell
AU - Ma, Qiang
T1 - Superinduction of metallothionein I by inhibition of protein synthesis: Role of a labile repressor in MTF-1 mediated gene transcription.
JO - Journal of Biochemical & Molecular Toxicology
JF - Journal of Biochemical & Molecular Toxicology
Y1 - 2006/04//
VL - 20
IS - 2
M3 - Article
SP - 57
EP - 68
SN - 10956670
AB - Induction of metallothioneins (MTs) through the metal-activated transcription factor-1 (MTF-1) provides a model response for analyzing transcriptional gene regulation by heavy metals. Here, we report inhibition of protein synthesis by cycloheximide (CHX) increases induction of Mt1 by approximately five-fold, a phenomenon designated as 'superinduction.' Characterization of superinduction revealed it is time- and concentration-dependent of CHX, requires the presence of an MTF-1 activator, and occurs at a transcriptional level, suggesting a labile repressor in the control of Mt1 induction. Genetic analyses using Mtf1 null cells and a metal response element (MRE)-driven reporter construct showed that superinduction of Mt1 is mediated through MTF-1 and MRE-dependent transcription. Analyses of intracellular zinc content by inductively coupled plasma emission spectroscopy and fluorescence imaging demonstrated that treatment with CHX alone or CHX plus an inducer does not increase the total zinc accumulation or the concentration of free zinc in cells under the conditions in which superinduction occurs. Moreover, superinduction was observed in cells cultured in a zinc-depleted medium, suggesting that superinduction does not involve elevation of intracellular zinc concentration. Northern blotting showed that Cd, CHX, or Cd + CHX does not affect the expression of the mRNA of MTF-1. Immunoblotting using antibodies specific for MTF-1 demonstrated that Cd induces a down-regulation of the MTF-1 protein, whereas cotreatment with Cd and CHX blocked the Cd-induced degradation of MTF-1. The findings reveal a new mechanistic aspect of the superinduction of Mt1, in which a labile repressor negatively controls agonist-induced turnover of the MTF-1 protein. © 2006 Wiley Periodicals, Inc. J Biochem Mol Toxicol 20:57-68, 2006; Published online in Wiley InterScience (). DOI 10.1002/jbt.20116 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biochemical & Molecular Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64238222; Bi, Yongyi 1,2; Lin, Gary X. 1; Millecchia, Lyndell 3; Ma, Qiang 1; Affiliations: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, Morgantown, WV 26505, USA; 2: School of Public Health, Wuhan University, Wuhan, People's Republic of China; 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA; Issue Info: Apr2006, Vol. 20 Issue 2, p57; Number of Pages: 12p; Document Type: Article
L3 - 10.1002/jbt.20116
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wu, John Z.
AU - Herzog, Walter
T1 - Analysis of the mechanical behavior of chondrocytes in unconfined compression tests for cyclic loading
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2006/04//
VL - 39
IS - 4
M3 - Article
SP - 603
EP - 616
SN - 00219290
AB - Abstract: Experimental evidence indicates that the biosynthetic activity of chondrocytes is associated with the mechanical environment. For example, excessive, repetitive loading has been found to induce cell death, morphological and cellular damage, as seen in degenerative joint disease, while cyclic, physiological-like loading has been found to trigger a partial recovery of morphological and ultrastructural aspects in osteoarthritic human articular chondrocytes. Mechanical stimuli are believed to influence the biosynthetic activity via the deformation of cells. However, the in situ deformation of chondrocytes for cyclic loading conditions has not been investigated experimentally or theoretically. The purpose of the present study was to simulate the mechanical response of chondrocytes to cyclic loading in unconfined compression tests using a finite element model. The material properties of chondrocytes and extracellular matrix were considered to be biphasic. The time-histories of the shape and volume variations of chondrocytes at three locations (i.e., surface, center, and bottom) within the cartilage were predicted for static and cyclic loading conditions at two frequencies (0.02 and 0.1Hz) and two amplitudes (0.1 and 0.2MPa). Our results show that cells at different depths within the cartilage deform differently during cyclic loading, and that the depth dependence of cell deformation is influenced by the amplitude of the cyclic loading. Cell deformations under cyclic loading of 0.02Hz were found to be similar to those at 0.1Hz. We conclude from the simulation results that, in homogeneous cartilage layers, cell deformations are location-dependent, and further are affected by load magnitude. In physiological conditions, the mechanical environment of cells are even more complex due to the anisotropy, depth-dependent inhomogeneity, and tension-compression non-linearity of the cartilage matrix. Therefore, it is feasible to speculate that biosynthetic responses of chondrocytes to cyclic loading depend on cell location and load magnitude. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARTILAGE cells
KW - CELLS -- Mechanical properties
KW - BIOMECHANICS
KW - CONNECTIVE tissues
KW - Biphasic
KW - Cartilage
KW - Cell mechanics
KW - Cyclic loading
KW - Finite element analysis
KW - Poroelastic
N1 - Accession Number: 19606057; Wu, John Z. 1,2; Email Address: jwu@cdc.gov Herzog, Walter 2; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: The University of Calgary, Calgary, Alberta, Canada; Source Info: Apr2006, Vol. 39 Issue 4, p603; Subject Term: CARTILAGE cells; Subject Term: CELLS -- Mechanical properties; Subject Term: BIOMECHANICS; Subject Term: CONNECTIVE tissues; Author-Supplied Keyword: Biphasic; Author-Supplied Keyword: Cartilage; Author-Supplied Keyword: Cell mechanics; Author-Supplied Keyword: Cyclic loading; Author-Supplied Keyword: Finite element analysis; Author-Supplied Keyword: Poroelastic; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jbiomech.2005.01.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Peiling
AU - Fleming, Thomas
T1 - Simultaneous Use of Weighted Logrank and Standardized Kaplan-Meier Statistics.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2006/04//
VL - 16
IS - 2
M3 - Article
SP - 241
EP - 252
PB - Taylor & Francis Ltd
SN - 10543406
AB - Rank-based test procedures in censored survival data differ considerably in their sensitivity to various alternatives to the hypothesis of equality of underlying distributions. Procedures based on the simultaneous use of multiple statistics provide an appealing approach to obtaining more global sensitivity while maintaining the sensitivity to alternatives of interest. In this article, the joint distribution of weighted logrank statistics (to assess overall differences in time-to-event distributions) and a standardized difference in Kaplan-Meier estimates (to assess differences at a specific prespecified time post randomization) is obtained and this result is used to formulate statistical test procedures based on the simultaneous use of these two types of statistics. Simulations are used to assess small sample properties of this approach and its usefulness is illustrated in important recent oncology clinical trials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - DISTRIBUTION (Probability theory)
KW - ONCOLOGY
KW - STATISTICS
KW - PROBABILITY theory
KW - MATHEMATICS
KW - Censored data
KW - Clinical trials
KW - Joint distribution
KW - Rank-based statistics
N1 - Accession Number: 19762138; Yang, Peiling 1 Fleming, Thomas 2; Email Address: tfleming@u.washington.edu; Affiliation: 1: Food and Drug Administration, Silver Spring, Maryland, USA 2: Department of Biostatistics, University of Washington, Seattle, Washington, USA; Source Info: Apr2006, Vol. 16 Issue 2, p241; Subject Term: CLINICAL trials; Subject Term: DISTRIBUTION (Probability theory); Subject Term: ONCOLOGY; Subject Term: STATISTICS; Subject Term: PROBABILITY theory; Subject Term: MATHEMATICS; Author-Supplied Keyword: Censored data; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Joint distribution; Author-Supplied Keyword: Rank-based statistics; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10543400500508952
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106020353
T1 - Deliberate deceit of family members: a challenge to providers of clinical genetics services.
AU - Loud JT
AU - Weissman NE
AU - Peters JA
AU - Giusti RM
AU - Wilfond BS
AU - Burke W
AU - Greene MH
Y1 - 2006/04//4/1/2006
N1 - Accession Number: 106020353. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; letter. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
KW - Privacy and Confidentiality
KW - Genes, BRCA
KW - Genetic Screening -- Ethical Issues
KW - Mutation
KW - Female
KW - Genetic Counseling
KW - Middle Age
SP - 1643
EP - 1646
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 24
IS - 10
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 0732-183X
AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services; Food and Drug Administration, Rockville, MD 20853-7231, USA. LoudJ@mail.nih.gov
U2 - PMID: 16575016.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhao, S.
AU - McDermott, P. F.
AU - Friedman, S.
AU - Qaiyumi, S.
AU - Abbott, J.
AU - Kiessling, C.
AU - Ayers, S.
AU - Singh, R.
AU - Hubert, S.
AU - Sofos, J.
AU - White, D. G.
T1 - Characterization of Antimicrobial-Resistant Salmonella Isolated from Imported Foods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/04//
VL - 69
IS - 3
M3 - Article
SP - 500
EP - 507
SN - 0362028X
AB - Two-hundred eight Salmonella isolates recovered from over 5,000 imported foods entering the United States in 2001 were tested for antimicrobial susceptibilities and further characterized for quinolone resistance mechanisms, integron carriage, and genetic relatedness. Salmonella Weltevreden (20%), Salmonella Newport (6%), Salmonella Lexington (5%), and Salmonella Thompson (4%) were the four most common serotypes recovered. Twenty-three (11%) isolates were resistant to at least one antimicrobial, and seven (3.4%) to three or more antimicrobials. Resistance was most often observed to tetracycline (9%), followed by sulfamethoxazole (5%), streptomycin (4%), nalidixic acid (3%), and trimethoprim/sulfamethoxazole (2%). One Salmonella Schwarzengrund isolate recovered from squid imported from Taiwan exhibited resistance to eight antimicrobials, including ampicillin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, sulfamethoxazole, tetracycline, and trimethoprim/sulfamethoxazole. Six isolates (Salmonella Bareilly, Salmonella Derby, Salmonella Ohio and three Salmonella Schwarzengrund) contained class I integrons, which carried several resistance genes including dhfrI/dhfrXll, aadA, pse-1, and sat1, conferring resistance to trimethoprim/sulfamethoxazole, streptomycin, ampicillin, and streptothricin, respectively. Five of six nalidixic acid-resistant isolates possessed DNA point mutations at either Ser83 or Asp87 in DNA gyrase. One ciprofloxacin- resistant isolate possessed double mutations in DNA gyrase at positions Ser83 and Asp87 as well as a single mutation at Ser80 in parC. The top three serotypes identified, Salmonella Weltevreden (n = 41), Salmonella Newport (n = 13), and Salmonella Lexington (n = 11), were further characterized for genetic relatedness by pulsed-field gel electrophoresis. Fifty-five distinct pulsed-field gel electrophoresis patterns were observed among the 65 isolates, indicating extensive genetic diversity among these Salmonella serotypes contaminating imported foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food poisoning
KW - Food -- Microbiology
KW - Food science
KW - United States
N1 - Accession Number: 20234233; Zhao, S. 1; McDermott, P. F. 1; Friedman, S. 1; Qaiyumi, S. 1; Abbott, J. 1; Kiessling, C. 2; Ayers, S. 1; Singh, R. 1; Hubert, S. 1; Sofos, J. 3; White, D. G. 1; Email Address: dwhite@cvm.fda.gov; Affiliations: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708; 2: Denver District Laboratory, U.S. Food and Drug Administration, 6th & Kipling Streets, Building 20, Denver, Colorado 80225; 3: Department of Animal Science, Colorado State University, 350 West Pitkin Street, Fort Collins, Colorado 80523, USA; Issue Info: Apr2006, Vol. 69 Issue 3, p500; Thesaurus Term: Salmonella; Thesaurus Term: Food poisoning; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Food science; Subject: United States; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thammasuvimol, G.
AU - Seo, K. H.
AU - Song, K. V.
AU - Holt, P. S.
AU - Brackett, R. E.
T1 - Optimization of Ferrioxamine E Concentration as Effective Supplementation for Selective Isolation of Salmonella Enteritidis in Egg White.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/04//
VL - 69
IS - 3
M3 - Article
SP - 634
EP - 638
SN - 0362028X
AB - Utilization of ferrioxamine E (FE) as a sole source of iron distinguishes Salmonella from a number of related species, including Escherichia coli. FE is not able to serve as a source of iron for E. coli or the Proteus-Providencia-Morganella group. This confers a selective advantage on Salmonella Enteritidis in egg white supplemented with FE. The optimum concentration of FE that promoted a selective advantage for Salmonella in egg white was determined. Four supplementation concentrations were evaluated (25, 50, 200, and 500 µg/ml) in egg white artificially inoculated with proportionally mixed cultures of a rifampin-resistant strain of Salmonella Enteritidis (0.1 ml of 10² CFU/ml) and E. coli K-12 (0.1 ml of 10¹ through 108 CFU/ml). After a 24-h incubation at 37°C, Salmonella and E. coli populations were enumerated. At higher concentrations of FE (≤50 µg/ml), both Salmonella and E. coli were able to use the iron supplement (1 to 8.5 log CFU/ml and 1.8 to 8 log CFU/ml, respectively); however, lower FE concentrations (≤50 µg/ml) exclusively promoted Salmonella growth. Salmonella was unrecoverable without supplementation. This study indicates that optimum levels of FE supplementation in egg can improve the selective detection for Salmonella Enteritidis among other competitive organisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Microbiology
KW - Eggs
KW - Escherichia coli
KW - Food pathogens
KW - Salmonella enteritidis
N1 - Accession Number: 20234251; Thammasuvimol, G. 1; Seo, K. H. 1; Email Address: kseo@cfsan.fda.gov; Song, K. V. 1; Holt, P. S. 2; Brackett, R. E. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, Maryland 20740; 2: U.S. Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, Georgia 30605, USA; Issue Info: Apr2006, Vol. 69 Issue 3, p634; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Eggs; Thesaurus Term: Escherichia coli; Thesaurus Term: Food pathogens; Subject Term: Salmonella enteritidis; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Seo, K. H.
AU - Valentin-Bon, I. E.
AU - Brackett, R. E.
T1 - Detection and Enumeration of Salmonella Enteritidis in Homemade Ice Cream Associated with an Outbreak: Comparison of Conventional and Real-Time PCR Methods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/04//
VL - 69
IS - 3
M3 - Article
SP - 639
EP - 643
SN - 0362028X
AB - Salmonellosis caused by Salmonella Enteritidis (SE) is a significant cause of foodborne illnesses in the United States. Consumption of undercooked eggs and egg-containing products has been the primary risk factor for the disease. The importance of the bacterial enumeration technique has been enormously stressed because of the quantitative risk analysis of SE in shell eggs. Traditional enumeration methods mainly depend on slow and tedious most-probable-number (MPN) methods. Therefore, specific, sensitive, and rapid methods for SE quantitation are needed to collect sufficient data for risk assessment and food safety policy development. We previously developed a real-time quantitative PCR assay for the direct detection and enumeration of SE and, in this study, applied it to naturally contaminated ice cream samples with and without enrichment. The detection limit of the real-time PCR assay was determined with artificially inoculated ice cream. When applied to the direct detection and quantification of SE in ice cream, the real-time PCR assay was as sensitive as the conventional plate count method in frequency of detection. However, populations of SE derived from real-time quantitative PCR were approximately 1 log higher than provided by MPN and CFU values obtained by conventional culture methods. The detection and enumeration of SE in naturally contaminated ice cream can be completed in 3 h by this real-time PCR method, whereas the cultural enrichment method requires 5 to 7 days. A commercial immunoassay for the specific detection of SE was also included in the study. The real-time PCR assay proved to be a valuable tool that may be useful to the food industry in monitoring its processes to improve product quality and safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Eggs
KW - Food pathogens
KW - Salmonella enteritidis
KW - United States
N1 - Accession Number: 20234252; Seo, K. H. 1; Email Address: kseo@cfsan.fda.gov; Valentin-Bon, I. E. 1; Brackett, R. E. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Plant and Dairy Foods, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Apr2006, Vol. 69 Issue 3, p639; Thesaurus Term: Foodborne diseases; Thesaurus Term: Eggs; Thesaurus Term: Food pathogens; Subject Term: Salmonella enteritidis; Subject: United States; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106451298
T1 - Relative value in healthcare: cost-effectiveness of interventions.
AU - Siegel JE
AU - Clancy CM
Y1 - 2006/04//Apr-Jun2006
N1 - Accession Number: 106451298. Language: English. Entry Date: 20060602. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Cost Benefit Analysis
KW - Nursing Interventions
KW - Health Care Delivery
KW - Health Policy
KW - United States Agency for Healthcare Research and Quality
SP - 99
EP - 103
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 21
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rm. 6026, Rockville, MD 20850; jsiegel@ahrq.gov
U2 - PMID: 16540774.
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DP - EBSCOhost
DB - rzh
ER -
TY - CONF
AU - Whiting, Susan J.
AU - Calvo, Mona S.
T1 - Overview of the Proceedings from Experimental Biology 2005 Symposium: Optimizing Vitamin D Intake for Populations with Special Needs: Barriers to Effective Food Fortification and Supplementation.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/04//
VL - 136
IS - 4
M3 - Proceeding
SP - 1114
EP - 1116
SN - 00223166
AB - The article overviews the proceedings of the 2005 Experimental Biology Symposium titled "Optimizing Vitamin D Intake for Populations with Special Needs: Barriers to Effective Food Fortification and Supplementation." The symposium examines the reasons why there are many barriers in the provisions of enough vitamin D foods in compliance of the newly emerging recommendations about vitamin D nutrition. In addition, it also canvasses on the current upper intake level of vitamin D. Concerns on darkly pigmented skin which blocks cutaneous Vitamin D synthesis is also examined.
KW - CONFERENCES & conventions
KW - VITAMIN D
KW - CALCIUM regulating hormones
KW - STEROID hormones
KW - FAT-soluble vitamins
KW - DIETARY supplements
KW - FOOD additives
KW - NUTRITION
N1 - Accession Number: 20414744; Whiting, Susan J. 1; Email Address: susan.whiting@usask.ca Calvo, Mona S. 2; Affiliation: 1: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5C9 2: Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708; Source Info: Apr2006, Vol. 136 Issue 4, p1114; Subject Term: CONFERENCES & conventions; Subject Term: VITAMIN D; Subject Term: CALCIUM regulating hormones; Subject Term: STEROID hormones; Subject Term: FAT-soluble vitamins; Subject Term: DIETARY supplements; Subject Term: FOOD additives; Subject Term: NUTRITION; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Illustrations: 1 Chart, 2 Graphs; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvo, Mona S.
AU - Whiting, Susan J.
T1 - Public Health Strategies to Overcome Barriers to Optimal Vitamin D Status in Populations with Special Needs.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/04//
VL - 136
IS - 4
M3 - Article
SP - 1135
EP - 1139
SN - 00223166
AB - In North America, there is increasing public health awareness of the importance of adequate vitamin D intake to the maintenance of optimal vitamin D status and overall health. Experts now define this as circulating levels of 25-hydroxyvitamin D of 75–80 nmol/L. This serum level and high levels of dietary intake have been associated with significantly reduced risk of chronic diseases, such as osteoporosis, cardiovascular disease, diabetes, and some cancers. All of these diseases are more prevalent in the elderly of all races, and some are more prevalent and of greater severity among blacks than whites. Our objective is to review recent actions to increase public awareness of the health importance of maintaining optimal circulating 25(OH)D and potential strategies to increase vitamin D intake. Clinicians and educators are encouraged to promote improved vitamin D intake and status, particularly among the elderly and blacks. This will largely depend on combined efforts to judiciously fortify our food supply and to develop individual supplementation protocols for supplements or controlled use of UV light exposure to maintain optimal serum 25(OH)D, especially in high-risk groups. Growing evidence supports a low risk of toxicity with vitamin D use in fortification or supplementation, despite its past reputation of potential toxicity in excess. The cost to fortify food or supplements with vitamin D is relatively inexpensive compared with developing drugs used to treat or prevent chronic diseases; moreover, there is significant potential for broad health benefits in the reduced risk and prevention of multiple chronic diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - VITAMIN D
KW - STEROID hormones
KW - SERUM
KW - CHRONIC diseases
KW - OSTEOPOROSIS
KW - CARDIOVASCULAR diseases
KW - DIABETES
KW - NORTH America
KW - fortification
KW - supplementation
KW - vitamin D
N1 - Accession Number: 20414749; Calvo, Mona S. 1; Email Address: mona.calvo@cfsan.fda.gov Whiting, Susan J. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 2: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, 5K, Canada; Source Info: Apr2006, Vol. 136 Issue 4, p1135; Subject Term: PUBLIC health; Subject Term: VITAMIN D; Subject Term: STEROID hormones; Subject Term: SERUM; Subject Term: CHRONIC diseases; Subject Term: OSTEOPOROSIS; Subject Term: CARDIOVASCULAR diseases; Subject Term: DIABETES; Subject Term: NORTH America; Author-Supplied Keyword: fortification; Author-Supplied Keyword: supplementation; Author-Supplied Keyword: vitamin D; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Afshari, Aliakbar A.
AU - Stone, Sam
AU - Chen, Bean
AU - Schwegler-Berry, Diane
AU - Fletcher, W. Gary
AU - Goldsmith, W. Travis
AU - Vandestouwe, Kurt H.
AU - McKinney, Walter
AU - Castranova, Vincent
AU - Frazer, David G.
T1 - Design, Construction, and Characterization of a Novel Robotic Welding Fume Generator and Inhalation Exposure System for Laboratory Animals.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/04//
VL - 3
IS - 4
M3 - Article
SP - 194
EP - 203
PB - Taylor & Francis Ltd
SN - 15459624
AB - Respiratory effects observed in welders have included lung function changes, metal fume fever, bronchitis, and a possible increase in the incidence of lung cancer. Many questions remain unanswered regarding the causality and possible underlying mechanisms associated with the potential toxic effects of welding fume inhalation. The objective of the present study was to construct a completely automated, computer-controlled welding fume generation and inhalation exposure system to simulate real workplace exposures. The system comprised a programmable six-axis robotic welding arm, a water-cooled arc welding torch, and a wire feeder that supplied the wire to the torch at a programmed rate. For the initial studies, gas metal arc welding was performed using a stainless steel electrode. A flexible trunk was attached to the robotic arm of the welder and was used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Undiluted fume concentrations consistently ranged from 90–150 mg/m3 in the animal chamber during welding. Temperature and humidity remained constant in the chamber during the welding operation. The welding particles were composed of (from highest to lowest concentration) iron, chromium, manganese, and nickel as measured by inductively coupled plasma atomic emission spectroscopy. Size distribution analysis indicated the mass median aerodynamic diameter of the generated particles to be approximately 0.24 μm with a geometric standard deviation (σg) of 1.39. As determined by transmission and scanning electron microscopy, the generated aerosols were mostly arranged as chain-like agglomerates of primary particles. Characterization of the laboratory-generated welding aerosol has indicated that particle morphology, size, and chemical composition are comparable to stainless steel welding fume generated in other studies. With the development of this novel system, it will be possible to establish an animal model using controlled welding exposures from automated gas metal arc and flux-cored arc welding processes to investigate how welding fumes affect health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - inhalation exposure
KW - robotic welder
KW - welding fume
N1 - Accession Number: 101380220; Antonini, James M. 1; Email Address: jga6@cdc.gov; Afshari, Aliakbar A. 1; Stone, Sam 1; Chen, Bean 1; Schwegler-Berry, Diane 1; Fletcher, W. Gary 1; Goldsmith, W. Travis 1; Vandestouwe, Kurt H. 1; McKinney, Walter 1; Castranova, Vincent 1; Frazer, David G. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia.; Issue Info: Apr2006, Vol. 3 Issue 4, p194; Author-Supplied Keyword: inhalation exposure; Author-Supplied Keyword: robotic welder; Author-Supplied Keyword: welding fume; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 2 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620600584352
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martin Jr., Stephen B.
AU - Beamer, Bryan R.
AU - Moyer, Ernest S.
T1 - Evaluation of a High-Efficiency, Filter-Bank System.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/04//
VL - 3
IS - 4
M3 - Article
SP - 204
EP - 213
PB - Taylor & Francis Ltd
SN - 15459624
AB - National Institute for Occupational Safety and Health (NIOSH) investigators evaluated filtration efficiencies at three U.S. Postal Service (USPS) facilities. Ventilation and filtration systems (VFSs) had been installed after the 2001 bioterrorist attacks when the USPS unknowingly processed letters laden with B. anthracis spores. The new VFS units included high-efficiency particulate air (HEPA) filters and were required by USPS contract specifications to provide an overall filtration efficiency of at least 99.97% for particles between 0.3 μm and 3.0 μm. The USPS evaluation involved a modification of methodology used to test total filtration system efficiency in agricultural tractor cab enclosures. The modified sampling strategy not only proved effective for monitoring the total filtration system component of VFS performance but also distinguished between filtration systems performing to the high USPS performance criteria and those needing repair or replacement. The results clearly showed the importance of choosing a pair of optical particle counters that have been closely matched immediately prior to testing. The modified methodology is readily adaptable to any workplace wishing to evaluate air filtration systems, including high-efficiency systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - aerosol
KW - anthrax
KW - bioterrorism
KW - HEPA
KW - high-efficiency filter
KW - optical particle counter
N1 - Accession Number: 101380227; Martin Jr., Stephen B. 1; Beamer, Bryan R. 2; Email Address: beamerb@uwstout.edu; Moyer, Ernest S. 1; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia.; 2: Safety and Risk Control Program, University of Wisconsin-Stout, Menomonie, Wisconsin.; Issue Info: Apr2006, Vol. 3 Issue 4, p204; Author-Supplied Keyword: aerosol; Author-Supplied Keyword: anthrax; Author-Supplied Keyword: bioterrorism; Author-Supplied Keyword: HEPA; Author-Supplied Keyword: high-efficiency filter; Author-Supplied Keyword: optical particle counter; Number of Pages: 10p; Illustrations: 6 Black and White Photographs, 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1080/15459620600584378
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mazzuckelli, Lawrence
AU - Methner, Mark
AU - Delaney, Lisa
T1 - Air Contaminant Exposures Among Transportation Security Administration (TSA) “Checked Baggage” Screeners at Four International Airports.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/04//
VL - 3
IS - 4
M3 - Article
SP - D36
EP - D41
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article cites a case study regarding the Transportation Security Administration's (TSA) requests to conduct health hazard evaluations at four international airports in the U.S. TSA employees reported that contaminants found in the emissions of tug engines operating near checked baggage screening areas were related to health problems. The National Institute for Occupational Safety and Health conducted a general area and personal breathing zone examination at the airports. They found no evidence of an inhalational hazard from tug exhaust emissions.
KW - Health risk assessment
KW - Aircraft exhaust emissions
KW - International airports
KW - United States
KW - United States. Transportation Security Administration
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 19876072; Mazzuckelli, Lawrence; Methner, Mark 1; Delaney, Lisa 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: National Institute for Occupational Safety and Health, Atlanta Field Office, Atlanta, Georgia; Issue Info: Apr2006, Vol. 3 Issue 4, pD36; Thesaurus Term: Health risk assessment; Thesaurus Term: Aircraft exhaust emissions; Subject Term: International airports; Subject: United States ; Company/Entity: United States. Transportation Security Administration ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/15459620600580103
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Henneberger, Paul
AU - Goe, Sandra
AU - Miller, William
AU - Doney, Brent
AU - Groce, Dennis
T1 - Letter to the Editor.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/04//
VL - 3
IS - 4
M3 - Letter
SP - D42
EP - D43
PB - Taylor & Francis Ltd
SN - 15459624
AB - A response by Paul K. Henneberger, Sandra K. Goe, William E. Miller, Brent Doney and Dennis W. Groce to a letter to the editor about their article "Industries in the United States with Airborne Beryllium Exposure and Estimates of the Number of Current Workers Potentially Exposed" in the previous issue is presented.
KW - Letters to the editor
KW - Beryllium industry
N1 - Accession Number: 19876071; Henneberger, Paul 1; Goe, Sandra 1; Miller, William 1; Doney, Brent 1; Groce, Dennis 1; Affiliations: 1: Division of Respiratory Disease, Studies National Institute for Occupational Safety and Health Centers of Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Apr2006, Vol. 3 Issue 4, pD42; Subject Term: Letters to the editor; Subject Term: Beryllium industry; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 2p; Document Type: Letter
L3 - 10.1080/15459620600574668
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106456104
T1 - Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals.
AU - Antonini JM
AU - Afshari AA
AU - Stone S
AU - Chen B
AU - Schwegler-Berry D
AU - Fletcher WG
AU - Goldsmith WT
AU - Vandestouwe KH
AU - McKinney W
AU - Castranova V
AU - Frazer DG
Y1 - 2006/04//
N1 - Accession Number: 106456104. Language: English. Entry Date: 20060616. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D44-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported by the National Toxicology Program. NLM UID: 101189458.
KW - Facility Design and Construction
KW - Inhalation Exposure -- Prevention and Control
KW - Metallurgy -- Adverse Effects
KW - Animals, Laboratory
KW - Education, Continuing (Credit)
KW - Funding Source
KW - Human
KW - Microscopy, Electron, Scanning
KW - Occupational Exposure
SP - 194
EP - 203
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Respiratory effects observed in welders have included lung function changes, metal fume fever, bronchitis, and a possible increase in the incidence of lung cancer. Many questions remain unanswered regarding the causality and possible underlying mechanisms associated with the potential toxic effects of welding fume inhalation. The objective of the present study was to construct a completely automated, computer-controlled welding fume generation and inhalation exposure system to simulate real workplace exposures. The system comprised a programmable six-axis robotic welding arm, a water-cooled arc welding torch, and a wire feeder that supplied the wire to the torch at a programmed rate. For the initial studies, gas metal arc welding was performed using a stainless steel electrode. A flexible trunk was attached to the robotic arm of the welder and was used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Undiluted fume concentrations consistently ranged from 90-150 mg/m(3) in the animal chamber during welding. Temperature and humidity remained constant in the chamber during the welding operation. The welding particles were composed of (from highest to lowest concentration) iron, chromium, manganese, and nickel as measured by inductively coupled plasma atomic emission spectroscopy. Size distribution analysis indicated the mass median aerodynamic diameter of the generated particles to be approximately 0.24 microm with a geometric standard deviation (sigma(g)) of 1.39. As determined by transmission and scanning electron microscopy, the generated aerosols were mostly arranged as chain-like agglomerates of primary particles. Characterization of the laboratory-generated welding aerosol has indicated that particle morphology, size, and chemical composition are comparable to stainless steel welding fume generated in other studies. With the development of this novel system, it will be possible to establish an animal model using controlled welding exposures from automated gas metal arc and flux-cored arc welding processes to investigate how welding fumes affect health.
SN - 1545-9624
AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505; jga6@cdc.gov
U2 - PMID: 16531292.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106456109
T1 - Evaluation of a high-efficiency, filter-bank system.
AU - Martin SB Jr.
AU - Beamer BR
AU - Moyer ES
Y1 - 2006/04//
N1 - Accession Number: 106456109. Language: English. Entry Date: 20060616. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; pictorial; research; tables/charts. Note: For CE see Suppl pages D44-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Biological Warfare -- Prevention and Control
KW - Filtration -- Evaluation
KW - Confidence Intervals
KW - Education, Continuing (Credit)
KW - Mail
KW - National Institute for Occupational Safety and Health
KW - United States
KW - Human
SP - 204
EP - 213
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - National Institute for Occupational Safety and Health (NIOSH) investigators evaluated filtration efficiencies at three U.S. Postal Service (USPS) facilities. Ventilation and filtration systems (VFSs) had been installed after the 2001 bioterrorist attacks when the USPS unknowingly processed letters laden with B. anthracis spores. The new VFS units included high-efficiency particulate air (HEPA) filters and were required by USPS contract specifications to provide an overall filtration efficiency of at least 99.97% for particles between 0.3 microm and 3.0 micro m. The USPS evaluation involved a modification of methodology used to test total filtration system efficiency in agricultural tractor cab enclosures. The modified sampling strategy not only proved effective for monitoring the total filtration system component of VFS performance but also distinguished between filtration systems performing to the high USPS performance criteria and those needing repair or replacement. The results clearly showed the importance of choosing a pair of optical particle counters that have been closely matched immediately prior to testing. The modified methodology is readily adaptable to any workplace wishing to evaluate air filtration systems, including high-efficiency systems.
SN - 1545-9624
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV
U2 - PMID: 16531293.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106456055
T1 - Case study. Air contaminant exposures among Transportation Security Administration (TSA) 'checked baggage' screeners at four international airports.
AU - Methner MM
AU - Delaney LJ
A2 - Mazzuckelli L
Y1 - 2006/04//
N1 - Accession Number: 106456055. Language: English. Entry Date: 20060616. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational
KW - Occupational Exposure
KW - Air Travel
KW - Carbon Monoxide
KW - Case Studies
KW - Florida
KW - Maryland
KW - Nitric Oxide
KW - Virginia
KW - Human
SP - D36
EP - 41
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16507517.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sama, Susan R.
AU - Milton, Donald K.
AU - Hunt, Phillip R.
AU - Houseman, E. Andres
AU - Henneberger, Paul K.
AU - Rosiello, Richard A.
T1 - Case-by-Case Assessment of Adult-Onset Asthma Attributable to Occupational Exposures Among Members of a Health Maintenance Organization.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/04//
VL - 48
IS - 4
M3 - Article
SP - 400
EP - 407
SN - 10762752
AB - Objective: In a general population of employed persons with health insurance, what proportion of adult-onset asthma is caused by occupational exposures? Method: We conducted a 2-year prospective study to identify adult-onset asthma among health maintenance organization (HMO) members. Telephone interviews regarding occupational exposures, symptoms, medication use, and triggers were used to assess likelihood of work-related asthma for each case. Weighted estimating equations were used to adjust the proportion of asthma attributable to workplace exposures for factors associated with interview participation. Results: Overall, 29% (95% confidence interval, 25-34%) of adult-onset asthma was attributable to workplace exposures; 26% (21-30%) and 22 % (18-27%) of cases had asthma attributable to occupational irritant and sensitizer exposures, respectively. Conclusions: Occupational exposures, including irritants, are important causes of adult-onset asthma. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL diseases
KW - ASTHMA
KW - HEALTH maintenance organizations
KW - OCCUPATIONAL medicine
KW - INDUSTRIAL hygiene
KW - ASTHMA in old age
KW - OBSTRUCTIVE lung diseases
KW - RESPIRATORY allergy
KW - LUNG diseases
N1 - Accession Number: 20737258; Sama, Susan R. 1 Milton, Donald K. 1,2 Hunt, Phillip R. 1,3 Houseman, E. Andres 1 Henneberger, Paul K. 4 Rosiello, Richard A. 5,6; Affiliation: 1: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: Department of Public Health, Boston, Massachusetts 4: Occupational Health Surveillance Program, Massachusetts 5: Research Department, the Division of Pulmonary and Critical Care Medicine, Worcester, Massachusetts 6: Department of Occupational Medicine, Fallon Clinic, Worcester, Massachusetts; Source Info: Apr2006, Vol. 48 Issue 4, p400; Subject Term: OCCUPATIONAL diseases; Subject Term: ASTHMA; Subject Term: HEALTH maintenance organizations; Subject Term: OCCUPATIONAL medicine; Subject Term: INDUSTRIAL hygiene; Subject Term: ASTHMA in old age; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: RESPIRATORY allergy; Subject Term: LUNG diseases; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1097/01.jom.0000199437.33100.cf
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boyce, Paul D.
AU - Jee Young Kim
AU - Weissman, David N.
AU - Hunt, John
AU - Christiani, David C.
T1 - pH Increase Observed in Exhaled Breath Condensate from Welding Fume Exposure.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/04//
VL - 48
IS - 4
M3 - Article
SP - 3534
EP - 356
SN - 10762752
AB - Objectives: We sought to investigate changes in exhaled breath condensate (EBC) pH in healthy workers exposed to welding fumes. Methods: Fourteen exposed participants (median age 39 years, 5 smokers) and 8 nonexposed controls (median age 44 years, I smoker) were monitored at an apprentice welding school. Exposure to fine particulate matter less than 2.5 µm (PM2.5) was assessed using cyclone samplers. EBC samples were collected at baseline and at the end of the work shift. EBC samples were deaerated using argon and pH values were measured using standard pH microelectrodes. Results: Mean ± SEM PM2.5 levels were 1.17 ± 0.18 mg/m³ for exposed subjects and 0.03 ± 0.01 mg/m³ for controls. Baseline median (range) EBC pH values for the control and exposed group were similar (P = 0.86), 7.21 (4.91 to 8.26), and 7.39 (4.85 to 7.79), respectively. The exposed subjects had a small-but-marginally significant (P = 0.07) pre- to post-work shift increase in pH of 0.28, whereas the control group showed a minimal increase of only 0.03 (P = 0.56). Compared with the control group, the exposed group had a median cross-shift pH increase of 0.25 (P = 0.49). Conclusions: The aerosolized fine particulate matter contained in metal fumes may be associated with an acute increase in EBC pH values. Further study is necessary to investigate the acute rise in EBC pH after acute exposure to welding fume. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WELDING -- Health aspects
KW - WELDING fumes
KW - WELDERS (Persons)
KW - HEALTH
KW - POISONOUS gases
KW - LUNG diseases
KW - PH effect
KW - RESPIRATION
KW - AEROSOLS (Sprays)
KW - BREATH tests
KW - PHYSIOLOGICAL aspects
N1 - Accession Number: 20737252; Boyce, Paul D. 1,2; Email Address: paulboyce@post.harvard.edu Jee Young Kim 1,3 Weissman, David N. 4 Hunt, John 5 Christiani, David C. 1,2; Affiliation: 1: Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 2: Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 3: National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 5: Division of Pediatric Respiratory Medicine, University of Virginia, Charlottesville, Virginia; Source Info: Apr2006, Vol. 48 Issue 4, p3534; Subject Term: WELDING -- Health aspects; Subject Term: WELDING fumes; Subject Term: WELDERS (Persons); Subject Term: HEALTH; Subject Term: POISONOUS gases; Subject Term: LUNG diseases; Subject Term: PH effect; Subject Term: RESPIRATION; Subject Term: AEROSOLS (Sprays); Subject Term: BREATH tests; Subject Term: PHYSIOLOGICAL aspects; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1097/01.jom.0000205988.50907.d8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Bernstein, IB;
AU - Shuren, J;
T1 - The Food and Drug Administration's counterfeit drug initiative
CT - The Food and Drug Administration's counterfeit drug initiative
JO - Journal of Pharmacy Practice (USA)
JF - Journal of Pharmacy Practice (USA)
Y1 - 2006/04/01/
VL - 19
IS - Apr
SP - 250
EP - 254
SN - 08971900
AD - US FDA, 5600 Fishers Lane, HF-11 Room 14C-03, Rockville, MD 20857, USA ilisa.bernstein@fda.gov
N1 - Accession Number: 44-01799; Language: English; References: 3; Journal Coden: JPPREU; Section Heading: Legislation, Laws and Regulations; Sociology, Economics and EthicsInformation Processing and Literature
N2 - There have been significant efforts by the public and private sector to further secure our nation's drug supply from counterfeit drugs. In 2004, FDA released a framework as guidance for these efforts and has been facilitating the implementation of this framework. Technology-based solutions, such as using radio-frequency identification (RFID) as a means to create an electronic pedigree that documents the movement of a drug product through the drug supply chain, is an important element of the framework. In 2005, two years after the release of the framework, FDA issued an update reporting the progress on reaching the goals of the framework, including RFID implementation, use of electronic pedigree, the pedigree requirements under the Prescription Drug Marketing Act. This article summarizes the findings of FDA's Counterfeit Drug Task Force 2006 Update. A full copy of the report can be accessed at http://www.fda.gov/oc/initiatives/counterfeit/report6
KW - Drugs--counterfeit;
KW - Computers--programs;
KW - Pharmacy--counterfeit drugs;
KW - Legislation--counterfeit drugs;
KW - Regulations--counterfeit drugs;
KW - Interventions--counterfeit drugs;
KW - Food and Drug Administration (U.S.)--regulations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Shulman, Jay D.
AU - Sutherland, James N.
T1 - Reports to the National Practitioner Data Bank involving dentists, 1990–2004.
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2006/04//
VL - 137
IS - 4
M3 - Article
SP - 523
EP - 528
SN - 00028177
AB - The article analyzes data relating to dentists in the U.S., based on reports from the National Practitioner Data Bank (NPDB) from 1900 to 2004. The study included malpractice payments, licensure actions and adverse actions against dentists. Of the total 13.2 percent of all NPDB reports, 73.7 percent resulted from malpractice actions and the remaining were from adverse actions. The number of large payments grew higher while the median payments continue its stability.
KW - INFORMATION storage & retrieval systems -- Medical personnel -- Malpractice
KW - NATIONAL Practitioner Data Bank (Information retrieval system)
KW - DENTISTS -- Malpractice
KW - DATA analysis
KW - MEDICINE -- Practice
KW - UNITED States
KW - dental malpractice
KW - National Practitioner Data Bank
KW - professional misconduct
N1 - Accession Number: 20720714; Shulman, Jay D. 1; Email Address: JShulman@bcd.tamhsc.edu Sutherland, James N. 2,3; Affiliation: 1: Professor and Graduate Program Director, Department of Public Health Sciences, Baylor College of Dentistry, The Texas A&M University System Health Science Center, 3302 Gaston Ave.. Dallas, Texas 75246 2: Captain, U.S. Public Health Service, Denver 3: Regional Dental Consultant, Health Resources and Services Administration, Office of Performance Review, Denver Regional Division; Source Info: Apr2006, Vol. 137 Issue 4, p523; Subject Term: INFORMATION storage & retrieval systems -- Medical personnel -- Malpractice; Subject Term: NATIONAL Practitioner Data Bank (Information retrieval system); Subject Term: DENTISTS -- Malpractice; Subject Term: DATA analysis; Subject Term: MEDICINE -- Practice; Subject Term: UNITED States; Author-Supplied Keyword: dental malpractice; Author-Supplied Keyword: National Practitioner Data Bank; Author-Supplied Keyword: professional misconduct; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chiesa, O. A.
AU - Von Bredow, J.
AU - Heller, D.
AU - Nochetto, C.
AU - Smith, M.
AU - Moulton, K.
AU - Thomas, M.
T1 - Use of tissue–fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/04//
VL - 29
IS - 2
M3 - Article
SP - 99
EP - 106
PB - Wiley-Blackwell
SN - 01407783
AB - Gentamicin continues to be one of the most effective antibiotics for the treatment of gram-negative infections. Greater than 90% of the drug is rapidly eliminated from the body in <2 days, however, a small residue remains bound to the kidney cortex tissue for many months. In beef steers, the gentamicin residue is unacceptable and its presence is monitored by the FAST (Fast Antimicrobial Screen Test) applied to the kidney at the time of slaughter. The sensitivity of the FAST to gentamicin in the kidney cortex is reported to be 100 ng/g, therefore, this level of gentamicin defines the acceptable limit of gentamicin drug residue in the bovine kidney. In the present study, three doses of 4 mg/kg gentamicin was administered intramuscularly to eight steers. Gentamicin was allowed to deplete from the kidneys for a range of times from 7 to 10 months. At slaughter the level of gentamicin in the kidney cortex varied from 91 to 193 ng/g, but a total of 160 FAST tests performed on the kidneys were negative. Blood and urine samples were collected at varying times following the last dose of gentamicin. Kidney tissue samples were collected by laparoscopic surgery in the live steers as well as the final sample obtained at slaughter. Plasma levels of gentamicin declined rapidly to nondetectable within 3 days, while measurable urine persisted for 75 days before the concentration of gentamicin declined to levels too low to quantitate by the available liquid chromatography tandem mass spectrometry (LC/MS/MS) technique. An estimated correlation between an extrapolation of urine gentamicin concentration to the corresponding kidney tissue sample suggests a urine to kidney tissue relationship of 1:100. A test system sufficiently sensitive to a urine gentamicin concentration of 1 ng/mL will correlate with the estimated 100 ng/g gentamicin limit of the FAST applied to the fresh kidney of the recently slaughtered bovine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENTAMICIN
KW - ANTIBACTERIAL agents
KW - ANTIBIOTICS
KW - BEEF cattle
KW - HOLSTEIN-Friesian cattle
KW - KIDNEY diseases
KW - LIQUID chromatography
N1 - Accession Number: 19901954; Chiesa, O. A. 1; Email Address: ochiesa@cvm.fda.gov Von Bredow, J. 1 Heller, D. 1 Nochetto, C. 1 Smith, M. 1 Moulton, K. 1 Thomas, M. 1; Affiliation: 1: Division of Residue Chemistry, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA; Source Info: Apr2006, Vol. 29 Issue 2, p99; Subject Term: GENTAMICIN; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTIBIOTICS; Subject Term: BEEF cattle; Subject Term: HOLSTEIN-Friesian cattle; Subject Term: KIDNEY diseases; Subject Term: LIQUID chromatography; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 112111 Beef Cattle Ranching and Farming; NAICS/Industry Codes: 112110 Beef cattle ranching and farming, including feedlots; NAICS/Industry Codes: 112112 Cattle Feedlots; Number of Pages: 8p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00720.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martina, Y.
AU - Marcucci, K. T.
AU - Cherqui, S.
AU - Szabo, A.
AU - Drysdale, T.
AU - Srinivisan, U.
AU - Wilson, C. A.
AU - Patience, C.
AU - Salomon, D. R.
T1 - Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral Infection.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/04//
VL - 80
IS - 7
M3 - Article
SP - 1
EP - 1
SN - 0022538X
AB - Porcine endogenous retrovirus (PERV) is considered one of the major risks in xenotransplantation. No valid animal model has been established to evaluate the risks associated with PERV transmission to human patients by pig tissue xenotransplantation or to study the potential pathogenesis associated with PERV infection. In previous work we isolated two genes encoding functional human PERV receptors and proved that introduction of these into mouse fibroblasts allowed the normally nonpermissive mouse cells to become productively infected (T. A. Ericsson, Y. Takeuchi, C. Templin, G. Quinn, S. F. Farhadian, J. C. Wood, B. A. Oldmixon, K. M. Suling, J. K. Ishii, Y. Kitagawa, T. Miyazawa, D. R. Salomon, R. A. Weiss, and C. Patience, Proc. Natl. Acad. Sci. USA 100:6759-6764, 2003). In the present study we created mice transgenic for human PERV-A receptor 2 (HuPAR-2). After inoculation of transgenic animals with infectious PERV supernatants, viral DNA and RNA were detected at multiple time points, indicating productive replication. This establishes the role of HuPAR-2 in PERV infection in vivo; in addition, these transgenic mice represent a new model for determining the risk of PERV transmission and potential pathogenesis. These mice also create a unique opportunity to study the immune response to PERV infection and test potential therapeutic or preventative modalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETROVIRUSES
KW - ANIMAL models in research
KW - TRANSGENIC mice
KW - VIRUS diseases
KW - MICE as laboratory animals
N1 - Accession Number: 20730147; Martina, Y. 1 Marcucci, K. T. 1 Cherqui, S. 1 Szabo, A. 1 Drysdale, T. 1 Srinivisan, U. 1 Wilson, C. A. 2 Patience, C. 3 Salomon, D. R. 1; Email Address: dsalomon@scripps.edu; Affiliation: 1: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037 2: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892 3: Biogen Idec, 14 Cambridge Center, Cambridge, Massachusetts 021423; Source Info: Apr2006, Vol. 80 Issue 7, p1; Subject Term: RETROVIRUSES; Subject Term: ANIMAL models in research; Subject Term: TRANSGENIC mice; Subject Term: VIRUS diseases; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.80.7.3135-3146.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bassen, H.
AU - Kainz, W.
AU - Mendoza, G.
AU - Kellom, T.
T1 - MRI‐induced heating of selected thin wire metallic implants – laboratory and computational studies – findings and new questions raised.
JO - Minimally Invasive Therapy & Allied Technologies
JF - Minimally Invasive Therapy & Allied Technologies
Y1 - 2006/04//
VL - 15
IS - 2
M3 - Article
SP - 76
EP - 84
PB - Taylor & Francis Ltd
SN - 13645706
AB - We performed experiments and computer modeling of heating of a cardiovascular stent and a straight, thin wire by RF fields in a 1.5 T MRI birdcage coil at 64 MHz. We used ASTM F2182‐02a standard and normalized results to 4 W/kg whole body average. We used a rectangular saline‐gel filled phantom and a coiled, double stent (Intracoil by ev3 Inc) 11 cm long. The stent had thin electrical insulation except for bare ends (simulating drug eluting coating). The stent and phantom were placed close to the wall of the RF Coil and had approximately 0.5°C initial temperature rise at the ends (local SAR = 320 W/kg). We exposed a wire (24.1 cm, 0.5 mm diameter) with 0.5 mm insulation and saw an 8.6°C temperature rise (local SAR = 5680 W/kg) at the bare ends. All heating was within 1 mm 3 of the ends, so the position of our fiber optic temperature probe was critical for repeatability. Our computational study used finite difference time domain software with a thermodynamics solver. We modeled a coiled bare‐wire stent as a spiral with a rectangular cross section and found a maximum increase of 0.05°C induced at the tips for plane wave exposures. A maximum local SAR of up to 200 W/kg occurred in a volume of only 8×10 -3 mm. We developed improved computational exposure sources – optimized birdcage coils and quasi‐MRI fields that may eliminate the need to model an RF coil. We learned that local (point) SAR (initial linear temperature rise) is the most reliable indicator of the maximum heating of an implant. Local SAR depends greatly on implant length, insulation and shape, and position in the MRI coil. Accurate heating must be measured with sensors or software having millimeter resolution. Many commercially available fiber optic temperature probes do meet this requirement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Minimally Invasive Therapy & Allied Technologies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIC resonance imaging
KW - IMPLANTED cardiovascular instruments
KW - CARDIAC pacemakers
KW - ARTIFICIAL implants
KW - RADIO frequency
KW - MEDICAL equipment
KW - heating
KW - magnetic resonance imaging
KW - medical implant
KW - MRI
KW - radio frequency
KW - RF
KW - safety
N1 - Accession Number: 20856080; Bassen, H. 1; Email Address: howard.bassen@fda.hhs.gov Kainz, W. 1 Mendoza, G. 1 Kellom, T. 1; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA; Source Info: Apr2006, Vol. 15 Issue 2, p76; Subject Term: MAGNETIC resonance imaging; Subject Term: IMPLANTED cardiovascular instruments; Subject Term: CARDIAC pacemakers; Subject Term: ARTIFICIAL implants; Subject Term: RADIO frequency; Subject Term: MEDICAL equipment; Author-Supplied Keyword: heating; Author-Supplied Keyword: magnetic resonance imaging; Author-Supplied Keyword: medical implant; Author-Supplied Keyword: MRI; Author-Supplied Keyword: radio frequency; Author-Supplied Keyword: RF; Author-Supplied Keyword: safety; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 9p; Illustrations: 5 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1080/13645700600640931
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, K.M.
AU - Gaba, J.
AU - Al-Khaldi, S.F.
T1 - Molecular identification of Yersinia enterocolitica isolated from pasteurized whole milk using DNA microarray chip hybridization
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2006/04//
VL - 20
IS - 2
M3 - Article
SP - 71
EP - 80
SN - 08908508
AB - Abstract: A DNA microarray chip of four virulence genes and 16S ribosomal DNA gene conserved region among all Gram negative species, including Yersinia, as a positive control was developed and evaluated using 22 Yersinia enterocolitica isolates. Eight different oligonucleotide probes (oligoprobes) with an average size of 22bp, complementary to the unique sequences of each gene, were designed and immobilized on the surface of chemically modified slides. Multiplex PCR was used to simultaneously amplify DNA target regions of all five genes, and single stranded DNA (ssDNA) samples for microarray analysis were prepared by using a primer extension of amplicons in the presence of one primer of all genes. The presence of genes in Y. enterocolitica was established by hybridization of the fluorescently labeled ssDNA representing different samples of the microarray gene-specific oligoprobes and confirmed by PCR. Results of the study showed specificity of genotyping Y. enterocolitica using multiple microarray-based assays. Final validation of the chip''s ability to identify Y. enterocolitica genes from adulterated pasteurized whole milk was confirmed and successful. The limit of chip detection of virulence genes in pasteurized whole milk was found to be 1000CFU per hybridization. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - CELL hybridization
KW - YERSINIA enterocolitica
KW - NUCLEIC acid probes
KW - DNA microarray
KW - Multiplex PCR
KW - Whole milk
KW - Yersinia enterocolitica
N1 - Accession Number: 20027897; Myers, K.M. 1 Gaba, J. 1 Al-Khaldi, S.F.; Email Address: sufian.al-khaldi@cfsan.fda.gov; Affiliation: 1: Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, HFS-517, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA; Source Info: Apr2006, Vol. 20 Issue 2, p71; Subject Term: DNA; Subject Term: CELL hybridization; Subject Term: YERSINIA enterocolitica; Subject Term: NUCLEIC acid probes; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: Multiplex PCR; Author-Supplied Keyword: Whole milk; Author-Supplied Keyword: Yersinia enterocolitica; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mcp.2005.09.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gambus, Agnieszka
AU - Jones, Richard C.
AU - Sanchez-Diaz, Alberto
AU - Kanemaki, Masato
AU - van Deursen, Frederick
AU - Edmondson, Ricky D.
AU - Labib, Karim
T1 - GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.
JO - Nature Cell Biology
JF - Nature Cell Biology
Y1 - 2006/04//
VL - 8
IS - 4
M3 - Article
SP - 358
EP - 366
PB - Nature Publishing Group
SN - 14657392
AB - The components of the replisome that preserve genomic stability by controlling the progression of eukaryotic DNA replication forks are poorly understood. Here, we show that the GINS (go ichi ni san) complex allows the MCM (minichromosome maintenance) helicase to interact with key regulatory proteins in large replisome progression complexes (RPCs) that are assembled during initiation and disassembled at the end of S phase. RPC components include the essential initiation and elongation factor, Cdc45, the checkpoint mediator Mrc1, the Tof1–Csm3 complex that allows replication forks to pause at protein–DNA barriers, the histone chaperone FACT (facilitates chromatin transcription) and Ctf4, which helps to establish sister chromatid cohesion. RPCs also interact with Mcm10 and topoisomerase I. During initiation, GINS is essential for a specific subset of RPC proteins to interact with MCM. GINS is also important for the normal progression of DNA replication forks, and we show that it is required after initiation to maintain the association between MCM and Cdc45 within RPCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Cell Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA replication
KW - CHROMOSOME replication
KW - GENETIC transcription
KW - EUKARYOTIC cells
KW - CELLS
KW - GENOMICS
KW - MOLECULAR genetics
N1 - Accession Number: 20456210; Gambus, Agnieszka 1 Jones, Richard C. 2 Sanchez-Diaz, Alberto 1 Kanemaki, Masato 1 van Deursen, Frederick 1 Edmondson, Ricky D. 2 Labib, Karim 1; Email Address: klabib@picr.man.ac.uk; Affiliation: 1: Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK 2: Food and Drug Administration, National Center for Toxicological Research (FDA/NCTR), 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Apr2006, Vol. 8 Issue 4, p358; Subject Term: DNA replication; Subject Term: CHROMOSOME replication; Subject Term: GENETIC transcription; Subject Term: EUKARYOTIC cells; Subject Term: CELLS; Subject Term: GENOMICS; Subject Term: MOLECULAR genetics; Number of Pages: 9p; Illustrations: 7 Diagrams, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1038/ncb1382
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sullivan, Roberta
T1 - Light can wreak havoc on CVCs.
JO - Nursing
JF - Nursing
Y1 - 2006/04//
VL - 36
IS - 4
M3 - Article
SP - 26
EP - 26
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article presents guidelines for storing and using central venous catheters and other medical devices. Labeling recommendations should be followed. Opaque double wrapping can be used to protect products from light exposure. Expiration dates should be checked before using any medical device. Closely examining devices before using. Return devices involved in adverse events or malfunctions to the biomedical services or engineering department.
KW - CATHETERS
KW - MEDICAL equipment
KW - DRUG delivery systems
KW - WRAPPING materials
KW - LABELS
N1 - Accession Number: 20245464; Sullivan, Roberta 1; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health; Source Info: Apr2006, Vol. 36 Issue 4, p26; Subject Term: CATHETERS; Subject Term: MEDICAL equipment; Subject Term: DRUG delivery systems; Subject Term: WRAPPING materials; Subject Term: LABELS; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Gierhart, Brenda S.
T1 - When Does a "Less Than Perfect" Sex Life Become Female Sexual Dysfunction?
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2006/04//
VL - 107
IS - 4
M3 - Editorial
SP - 750
EP - 751
SN - 00297844
AB - The article offers views on when problems of sexual function become female sexual dysfunction. According to the author, the definition of female sexual dysfunction is such a problem because it does not exist as a diagnosis. The author believes it is a spectrum of disorders with overlap between the disorders. Female sexual dysfunction consists of 4 recognized components, decreased sexual desire, decreased sexual arousal, dyspareunia, and difficulty in achieving or inability to achieve orgasm.
KW - SEXUAL disorders
KW - SEXUAL dysfunction
KW - WOMEN -- Sexual behavior
KW - SEXUAL excitement
KW - DYSPAREUNIA
N1 - Accession Number: 23468914; Gierhart, Brenda S. 1; Affiliation: 1: Division of Metabolism and Endocrinology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring; Source Info: Apr2006, Vol. 107 Issue 4, p750; Subject Term: SEXUAL disorders; Subject Term: SEXUAL dysfunction; Subject Term: WOMEN -- Sexual behavior; Subject Term: SEXUAL excitement; Subject Term: DYSPAREUNIA; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105849102
T1 - Chemotherapeutic approaches for targeting cell death pathways.
AU - Ricci MS
AU - Zong WX
Y1 - 2006/04//
N1 - Accession Number: 105849102. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Antineoplastic Agents -- Pharmacodynamics
KW - Cell Death -- Drug Effects
KW - Neoplasms -- Metabolism
KW - Signal Transduction -- Drug Effects
KW - Animals
KW - Antineoplastic Agents -- Therapeutic Use
KW - Apoptosis -- Drug Effects
KW - Cell Aging -- Drug Effects
KW - Cell Physiology -- Drug Effects
KW - Clinical Trials
KW - Necrosis -- Chemically Induced
KW - Neoplasms -- Drug Therapy
KW - Neoplasms -- Pathology
KW - Oncogenes -- Drug Effects
KW - Receptors, Cell Surface -- Drug Effects
KW - Receptors, Cell Surface -- Metabolism
KW - Signal Transduction
SP - 342
EP - 357
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 11
IS - 4
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death in mammalian tissues. It also has been increasingly noted that conventional chemotherapeutic agents not only elicit apoptosis but other forms of nonapoptotic death such as necrosis, autophagy, mitotic catastrophe, and senescence. This review presents background on the signaling pathways involved in the different cell death outcomes. A re-examination of what we know about chemotherapy-induced death is vitally important in light of new understanding of nonapoptotic cell death signaling pathways. If we can precisely activate or inhibit molecules that mediate the diversity of cell death outcomes, perhaps we can succeed in more effective and less toxic chemotherapeutic regimens.
SN - 1083-7159
AD - National Cancer Institute and Food and Drug Administration Interagency Oncology Task Force, Bethesda, Maryland, USA.
U2 - PMID: 16614230.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tanofsky-Kraff, Marian
AU - Cohen, Marc L.
AU - Yanovski, Susan Z.
AU - Cox, Christopher
AU - Theim, Kelly R.
AU - Keil, Margaret
AU - Reynolds, James C.
AU - Yanovski, Jack A.
T1 - A Prospective Study of Psychological Predictors of Body Fat Gain Among Children at High Risk for Adult Obesity.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/04//
VL - 117
IS - 4
M3 - Article
SP - 1203
EP - 1209
SN - 00314005
AB - OBJECTIVE. Limited data suggest that psychological factors, including binge eating, dieting, and depressive symptoms, may predispose children to excessive weight gain. We investigated the relationship between baseline psychological measures and changes in body fat (measured with dual-energy x-ray absorptiometry) over time among children thought to be at high risk for adult obesity. METHODS. A cohort study of a convenience sample of children (age: 6-12 years) recruited from Washington, DC, and its suburbs was performed. Subjects were selected to be at increased risk for adult obesity, either because they were overweight when first examined or because their parents were overweight. Children completed questionnaires at baseline that assessed dieting, binge eating, disordered eating attitudes, and depressive symptoms; they underwent measurements of body fat mass at baseline and annually for an average of 4.2 years (SD: 1.8 years). RESULTS. Five hundred sixty-eight measurements were obtained between July 1996 and December 2004, for 146 children. Both binge eating and dieting predicted increases in body fat. Neither depressive symptoms nor disturbed eating attitudes served as significant predictors. Children who reported binge eating gained, on average, 15% more fat mass, compared with children who did not report binge eating. CONCLUSIONS. Children's reports of binge eating and dieting were salient predictors of gains in fat mass during middle childhood among children at high risk for adult obesity. Interventions targeting disordered eating behaviors may be useful in preventing excessive fat gain in this high-risk group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PSYCHOLOGICAL factors
KW - WEIGHT gain
KW - CHILDREN
KW - OBESITY
KW - OVERWEIGHT children
KW - COMPULSIVE eating
KW - REDUCING diets
KW - adiposity
KW - child
KW - depression
KW - disturbed eating behaviors
KW - overweight
N1 - Accession Number: 20545907; Tanofsky-Kraff, Marian 1 Cohen, Marc L. 1 Yanovski, Susan Z. 1,2,3 Cox, Christopher 4,5 Theim, Kelly R. 1 Keil, Margaret 1 Reynolds, James C. 6 Yanovski, Jack A. 1; Email Address: jy15i@nih.gov; Affiliation: 1: Unit on Growth and Obesity, Developmental Endocrinology Branch, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 2: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 3: US Public Health Service 4: Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 5: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 6: Nuclear Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland; Source Info: Apr2006, Vol. 117 Issue 4, p1203; Subject Term: PSYCHOLOGICAL factors; Subject Term: WEIGHT gain; Subject Term: CHILDREN; Subject Term: OBESITY; Subject Term: OVERWEIGHT children; Subject Term: COMPULSIVE eating; Subject Term: REDUCING diets; Author-Supplied Keyword: adiposity; Author-Supplied Keyword: child; Author-Supplied Keyword: depression; Author-Supplied Keyword: disturbed eating behaviors; Author-Supplied Keyword: overweight; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2005-1329
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rader, Jeanne I.
AU - Schneeman, Barbara O.
T1 - Prevalence of Neural Tube Defects, Folate Status, and Folate Fortification of Enriched Cereal-Grain Products in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/04//
VL - 117
IS - 4
M3 - Article
SP - 1394
EP - 1399
SN - 00314005
AB - Deals with the prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the U.S. Discussion on mandatory fortification of enriched cereal-grain products with folate; Changes in folate status of the U.S. population after fortification; Assessment of the effectiveness of fortification.
KW - NEURAL tube -- Abnormalities
KW - FOLIC acid antagonists
KW - FORTIFICATION
KW - CEREAL products
KW - NERVOUS system
KW - UNITED States
KW - public health
KW - public policy
N1 - Accession Number: 20545929; Rader, Jeanne I. 1; Email Address: Jeanne.Rader@cfsan.fda.gov Schneeman, Barbara O. 1; Affiliation: 1: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Apr2006, Vol. 117 Issue 4, p1394; Subject Term: NEURAL tube -- Abnormalities; Subject Term: FOLIC acid antagonists; Subject Term: FORTIFICATION; Subject Term: CEREAL products; Subject Term: NERVOUS system; Subject Term: UNITED States; Author-Supplied Keyword: public health; Author-Supplied Keyword: public policy; NAICS/Industry Codes: 311230 Breakfast Cereal Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1542/peds.2005-2745
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106303299
T1 - Prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the United States.
AU - Rader JI
AU - Schneeman BO
Y1 - 2006/04//
N1 - Accession Number: 106303299. Language: English. Entry Date: 20060714. Revision Date: 20150711. Publication Type: Journal Article. Commentary: Brent RL, Oakley GP Jr. The folate debate. (PEDIATRICS) Apr2006; 117 (4): 1418-1419. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Folic Acid -- Administration and Dosage
KW - Food
KW - Food, Fortified
KW - Neural Tube Defects -- Epidemiology
KW - Cereals
KW - Dietary Supplements
KW - Female
KW - Folic Acid -- Blood
KW - Food Preferences
KW - Hispanics
KW - Infant, Newborn
KW - Neural Tube Defects -- Ethnology
KW - Neural Tube Defects -- Prevention and Control
KW - Nutritional Requirements
KW - Pregnancy
KW - Prevalence
KW - United States
SP - 1394
EP - 1399
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 117
IS - 4
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740; Jeanne.Rader@cfsan.fda.gov
U2 - PMID: 16585338.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Devadas, Krishnakumar
AU - Boykins, Robert A.
AU - Hardegen, Neil J.
AU - Philp, Deborah
AU - Kleinman, Hynda K.
AU - Osa, Etin-Osa
AU - Wang, Jiun
AU - Clouse, Kathleen A.
AU - Wahl, Larry M.
AU - Hewlett, Indira K.
AU - Rappaport, Jay
AU - Yamada, Kenneth M.
AU - Dhawan, Subhash
T1 - Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides
JO - Peptides
JF - Peptides
Y1 - 2006/04//
VL - 27
IS - 4
M3 - Article
SP - 611
EP - 621
SN - 01969781
AB - Abstract: Extracellular Tat protein of HIV-1 activates virus replication in HIV-infected cells and induces a variety of host factors in the uninfected cells, some of which play a critical role in the progression of HIV infection. The cysteine-rich and arginine-rich basic domains represent key components of the HIV-Tat protein for pathogenic effects of the full-length Tat protein and, therefore, could be ideal candidates for the development of a therapeutic AIDS vaccine. The present study describes selective modifications of the side-chain functional groups of cysteine and arginine amino acids of these HIV-Tat peptides to minimize the pathogenic effects of these peptides while maintaining natural peptide linkages. Modification of cysteine by introducing either a methyl or t-butyl group in the free sulfhydryl group and replacing the guanidine group with a urea linkage in the side chain of arginine in the cysteine-rich and arginine-rich Tat peptide sequences completely blocked the ability of these peptides to induce HIV replication, chemokine receptor CCR-5 expression, and NF-κB activity in monocytes. Such modifications also inhibited angiogenesis and migration of Kaposi''s sarcoma cells normally induced by Tat peptides. Such chemical modifications of the cysteine-rich and arginine-rich peptides did not affect their reactivity with antibodies against the full-length Tat protein. With an estimated 40 million HIV-positive individuals worldwide and approximately 4 million new infections emerging every year, a synthetic subunit HIV-Tat vaccine comprised of functionally inactive Tat domains could provide a safe, effective, and economical therapeutic vaccine to reduce the progression of HIV disease. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - CYSTEINE proteinases
KW - MONOCYTES
KW - PEPTIDES
KW - AIDS
KW - HIV-Tat
KW - Peptides
KW - Vaccination
N1 - Accession Number: 20523459; Devadas, Krishnakumar 1 Boykins, Robert A. 2 Hardegen, Neil J. 3 Philp, Deborah 4 Kleinman, Hynda K. 4 Osa, Etin-Osa 1 Wang, Jiun 5 Clouse, Kathleen A. 5 Wahl, Larry M. 6 Hewlett, Indira K. 1 Rappaport, Jay 7 Yamada, Kenneth M. 4 Dhawan, Subhash 1; Email Address: dhawan@cber.fda.gov; Affiliation: 1: Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315), Rockville, MD 20852-1448, USA 2: Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike (HFM-315), Rockville, MD 20852-1448, USA 3: Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA 4: Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA 5: Laboratory of Cell Biology, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 6: Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA 7: Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, PA 19122, USA; Source Info: Apr2006, Vol. 27 Issue 4, p611; Subject Term: HIV infections; Subject Term: CYSTEINE proteinases; Subject Term: MONOCYTES; Subject Term: PEPTIDES; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: HIV-Tat; Author-Supplied Keyword: Peptides; Author-Supplied Keyword: Vaccination; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.peptides.2005.09.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Senior, John R.
T1 - How can 'Hy's law' help the clinician?
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2006/04//
VL - 15
IS - 4
M3 - Article
SP - 235
EP - 239
SN - 10538569
N1 - Accession Number: 64708937; Senior, John R. 1; Affiliations: 1: Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration HFD-030, Silver Spring, MD, USA; Issue Info: Apr2006, Vol. 15 Issue 4, p235; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.1210
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Temple, Robert
T1 - Hy's law: predicting serious hepatotoxicity.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2006/04//
VL - 15
IS - 4
M3 - Article
SP - 241
EP - 243
SN - 10538569
N1 - Accession Number: 64708939; Temple, Robert 1; Affiliations: 1: Associate Director for Medical Policy US Food and Drug Administration; Issue Info: Apr2006, Vol. 15 Issue 4, p241; Number of Pages: 3p; Document Type: Article
L3 - 10.1002/pds.1211
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Sharon A.
AU - Coelho, Sergio G.
AU - Zmudzka, Barbara Z.
AU - Beer, Janusz Z.
T1 - Reduction of the UV burden to indoor tanners through new exposure schedules: a pilot study.
JO - Photodermatology, Photoimmunology & Photomedicine
JF - Photodermatology, Photoimmunology & Photomedicine
Y1 - 2006/04//
VL - 22
IS - 2
M3 - Article
SP - 59
EP - 66
PB - Wiley-Blackwell
SN - 09054383
AB - Background: The development of new pigmentation (tan) in human skin after UV exposure requires several days. Once it is developed, the tan can last for weeks. Current recommendations for tanning exposure schedules in the USA (FDA Letter to Manufacturers: Policy on maximum timer interval and exposure schedule for sunlamps, August 21, 1986) allow exposures three times per week for the development of a tan, and one to two times per week for maintenance exposures. However, this policy is often interpreted in the indoor tanning industry as allowing three exposures per week on a continuous basis. We believe that the reduction of the recommended cumulative dose to indoor tanners should be explored. Two approaches for achieving this are (1) decreasing the number of exposures and (2) increasing the time interval between exposures. To explore such changes, we conducted a pilot study. Methods: The pilot study involved three exposure schedules (evaluated on each of six subjects) that evolved throughout the course of the study. Digital photography, visual assessment and diffuse reflectance spectrometry were used to assess skin color changes. The six pilot subjects were studied for 8–18 weeks. The changes in skin color obtained through the use of the different exposure schedules were compared with changes reported by Caswell (Caswell M, The kinetics of the tanning response to tanning bed exposures, Photodermatol Photoimmunol Photomed 2000: 16: 10–14) who used schedules based on current recommendations. Results: Two out of the three experimental schedules produced tans comparable with those reported by Caswell. In these two schedules, cumulative doses were a factor of 2–3 below doses from current schedules. Conclusion: The UV burden to indoor tanners can be substantially reduced without compromising the cosmetic effect. These results need to be confirmed in a larger study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Photodermatology, Photoimmunology & Photomedicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN skin color
KW - ULTRAVIOLET radiation
KW - DIGITAL photography
KW - REFLECTANCE spectroscopy
KW - EXPERIMENTAL dermatology
KW - RESEARCH
KW - indoor tanning
KW - pigmentation
KW - sunlamps
KW - UV
N1 - Accession Number: 20068879; Miller, Sharon A. 1 Coelho, Sergio G. 1 Zmudzka, Barbara Z. 1 Beer, Janusz Z. 1; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA; Source Info: Apr2006, Vol. 22 Issue 2, p59; Subject Term: HUMAN skin color; Subject Term: ULTRAVIOLET radiation; Subject Term: DIGITAL photography; Subject Term: REFLECTANCE spectroscopy; Subject Term: EXPERIMENTAL dermatology; Subject Term: RESEARCH; Author-Supplied Keyword: indoor tanning; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: sunlamps; Author-Supplied Keyword: UV; Number of Pages: 8p; Illustrations: 1 Color Photograph, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0781.2006.00206.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daniels, R. D.
AU - Lodwick, C. J.
AU - Schubauer-Berigan, M. K.
AU - Spitz, H. B.
T1 - ASSESSMENT OF PLUTONIUM EXPOSURES FOR AN EPIDEMIOLOGICAL STUDY OF US NUCLEAR WORKERS.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2006/04//
VL - 118
IS - 1
M3 - Article
SP - 43
EP - 55
SN - 01448420
AB - Au ongoing case-control study evaluating the association between workplace external radiation exposures and Ieukaemia mortality required an assessment of internal plutonium exposures as a potential confounder. Of the study participants, 1092 were employed at four Department of Energy sites where plutonium-bearing materials were processed or stored. Exposures were assessed by first categorising exposure potentials based on available bioassay data, then estimating doses for workers in the highest categories using recent recommendations of the International Commission on Radiological Protection. Given the aetiology of leukaemia, equivalent dose to active bone marrow was chosen as the exposure variable. There were 556 workers each with at least one plutonium bioassay result, assigned to one of three evaluation categories. Dose estimates were made for I 15 workers resulting in a collective equivalent dose of 2.1 person-Sv for 2822 exposure-years, compared with 29.8 person-Sv estimated from photon exposures. Modelling uncertainties were examined by comparison of results from independent analyses and by Monte Carlo simulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radiation exposure
KW - Plutonium
KW - Biological assay
KW - Diseases -- Causes & theories of causation
KW - Leukemia
KW - Mortality
KW - Photon emission
KW - United States. Dept. of Energy
KW - International Commission on Radiological Protection
N1 - Accession Number: 21211410; Daniels, R. D. 1; Email Address: RTD2@CDC.gov; Lodwick, C. J. 2; Schubauer-Berigan, M. K. 1; Spitz, H. B. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH) 5555, Ridge Avenue, R-44 Cincinnati, OH 45213, USA; 2: Westat Inc., 1650 Research Blvd, Rockville, MD 20850-3129, USA; Issue Info: 2006, Vol. 118 Issue 1, p43; Thesaurus Term: Radiation exposure; Thesaurus Term: Plutonium; Thesaurus Term: Biological assay; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Leukemia; Subject Term: Mortality; Subject Term: Photon emission ; Company/Entity: United States. Dept. of Energy ; Company/Entity: International Commission on Radiological Protection; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 13p; Illustrations: 9 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/rpd/nci330
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Doerge, Daniel R.
AU - Twaddle, Nathan C.
AU - Churchwell, Mona I.
AU - Newbold, Retha R.
AU - Delclos, K. Barry
T1 - Lactational transfer of the soy isoflavone, genistein, in Sprague–Dawley rats consuming dietary genistein
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2006/04//
VL - 21
IS - 3
M3 - Article
SP - 307
EP - 312
SN - 08906238
AB - Abstract: Exposures of Sprague–Dawley rats to the soy isoflavone, genistein, throughout the entire lifespan have produced a number of effects on reproductive tissues, immune function, neuroendocrine function and behavior. Our previous studies investigated pharmacokinetics and disposition of genistein during adult and fetal periods and this study describes the internal exposures of post-natal day 10 (PND10) rat pups due to lactational transfer of genistein. Conjugated and aglycone forms of genistein were measured by using LC/MS/MS in serum (PND10) and milk (PND7) from lactating dams consuming a genistein-fortified soy-free diet, and in serum from their pups at a time when milk was the only food source (PND10). This study shows that limited lactational transfer of genistein to rat pups occurs and that internal exposures to the active aglycone form of genistein are generally lower than those measured previously in the fetal period. These results suggest that developmental effects attributable to genistein exposure in our chronic and multi-generation studies are more likely to result from fetal exposures because of the higher levels of the active estrogenic aglycone form of genistein in utero, although the possibility of neonatal responses cannot be excluded. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MURIDAE
KW - BREASTFEEDING (Humans)
KW - PRESERVATION of organs, tissues, etc.
KW - DRUG metabolism
KW - Genistein
KW - Lactation
KW - Mass spectrometry
KW - Neonatal
KW - Soy
N1 - Accession Number: 19860008; Doerge, Daniel R. 1; Email Address: ddoerge@nctr.fda.gov Twaddle, Nathan C. 1 Churchwell, Mona I. 1 Newbold, Retha R. 2 Delclos, K. Barry 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Developmental Endocrinology and Endocrine Disrupter Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, NC 27709, USA; Source Info: Apr2006, Vol. 21 Issue 3, p307; Subject Term: MURIDAE; Subject Term: BREASTFEEDING (Humans); Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: DRUG metabolism; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Lactation; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Neonatal; Author-Supplied Keyword: Soy; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.reprotox.2005.09.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jian Yan
AU - Qingsu Xia
AU - Webb, Peggy
AU - Warbritton, Alan R.
AU - Wamer, Wayne G.
AU - Howard, Paul C.
AU - Boudreau, Mary
AU - Fu, Peter P.
T1 - Levels of retinyl palmitate and retinol in stratum corneum, epidermis and dermis of SKH-1 mice.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2006/04//
VL - 22
IS - 3
M3 - Article
SP - 103
EP - 112
PB - Sage Publications, Ltd.
SN - 07482337
AB - Vitamin A (retinol) regulates many biological functions, including epidermal cell growth. Retinyl palmitate (RP) is the major esterified form of retinol and the predominant component of retinoids in the skin; however, how endogenous levels of RP and retinol in the skin are affected by the age of the animal remains unknown. Furthermore, the levels of retinol and RP in the various skin layers – the stratum corneum, epidermis and dermis of skin – have not been reported. In this paper, we report the development of a convenient method for separation of the skin from SKH-1 female mice into the stratum corneum, epidermis, and dermis and the determination of the levels of RP and retinol in the three fractions by HPLC analysis. The total quantities of RP and retinol from the stratum corneum, epidermis, and dermis are comparable to those extracted from the same amount of intact skin from the same mouse. There was an age-related effect on the levels of RP and retinol in the skin and liver of female mice. An age-related effect was also observed in the stratum corneum, epidermis, and dermis. The levels of RP and retinol were highest in the epidermis of 20-week-old mice, and decreased when the age increased to 60- and 68-weeks. The total amount of RP at 20 weeks of age was found to be 1.52 ng/mg skin, and decreased about 4-fold at 60- and 68-weeks of age. A similar trend was found for the effects of age on the levels of retinol. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mice
KW - Vitamin A
KW - Skin
KW - Dermis
KW - Epidermis
KW - Retinoids
KW - Tretinoin
KW - Age
KW - Epithelium
KW - RETINOL
KW - RETINYL PALMITATE
KW - skin
N1 - Accession Number: 20330843; Jian Yan 1; Qingsu Xia 1; Webb, Peggy 2; Warbritton, Alan R. 2; Wamer, Wayne G. 3; Howard, Paul C. 1; Boudreau, Mary 1; Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; 2: Toxicological Pathology Associates, Jefferson, AR 72079, USA; 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Issue Info: 2006, Vol. 22 Issue 3, p103; Thesaurus Term: Mice; Subject Term: Vitamin A; Subject Term: Skin; Subject Term: Dermis; Subject Term: Epidermis; Subject Term: Retinoids; Subject Term: Tretinoin; Subject Term: Age; Subject Term: Epithelium; Author-Supplied Keyword: RETINOL; Author-Supplied Keyword: RETINYL PALMITATE; Author-Supplied Keyword: skin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1191/0748233706th252oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20330843&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rios, Maria
AU - Zhang, Ming J.
AU - Grinev, Andriyan
AU - Srinivasan, Kumar
AU - Daniel, Sylvester
AU - Wood, Owen
AU - Hewlett, Indira K.
AU - Dayton, Andrew I.
T1 - Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusion.
JO - Transfusion
JF - Transfusion
Y1 - 2006/04//
VL - 46
IS - 4
M3 - Article
SP - 659
EP - 667
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: West Nile virus (WNV) transmission by transfusion was documented in 2002. Approximately 80 percent of WNV infections are asymptomatic and 1 percent develop severe neurological illness. In animals, Langerhans-dendritic cells support initial viral replication, followed by replication in lymphoid tissues and dissemination to organs and possibly to the CNS. The cellular tropism of WNV infection after transfusion and the particular human blood cells that sustain viral replication remain largely unknown. Whether primary monocyte-derived macrophages (MDMs) support WNV infection-replication and produce infectious virions, with an in vitro system, was investigated. STUDY DESIGN AND METHODS: Elutriated monocytes (CD33+/CD14+) from suitable blood donors were cultured in the presence of macrophage–colony-stimulating factor, infected with WNV-NY99 at different time points, washed, and cultivated for up to 47 days. Supernatants were tested for WNV replication by TaqMan reverse transcription–polymerase chain reaction (RT-PCR), with primers for the envelope and/or 3′NC regions, and by cDNA-PCR to detect WNV minus-strand RNA and for the presence of functional virions by infectivity assays in Vero cells. RESULTS: RT-PCR TaqMan of supernatants demonstrated productive infection of MDMs. Viral load reached 2 to 5 log above baseline in 3 to 6 days and then declined, with detectable viral replication persisting for up to 47 days. WNV minus-strand RNA was detected in Day 4 cultures, indicating active viral replication. Infected MDM cultures showed no cytopathic changes. Supernatants that were TaqMan-positive for the presence of WNV-infected Vero cells and produced cytopathic effects within 3 to 5 days of culture. CONCLUSION: The susceptibility of monocytes-macrophages to productive infection in vitro is compatible with a potential role in initial WNV replication and propagation after transmission by transfusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEST Nile virus
KW - VIRAL replication
KW - BLOOD transfusion
KW - LANGERHANS cells
KW - MONOCYTES
KW - MACROPHAGES
KW - BLOOD donors
KW - POLYMERASE chain reaction
N1 - Accession Number: 20274267; Rios, Maria 1; Email Address: maria.rios@fda.hhs.gov Zhang, Ming J. 1 Grinev, Andriyan 1 Srinivasan, Kumar 1 Daniel, Sylvester 1 Wood, Owen 1 Hewlett, Indira K. 1 Dayton, Andrew I. 1; Email Address: andrew.dayton@fda.hhs.gov; Affiliation: 1: Laboratory of Molecular Virology (LMV), Division of Emerging Transfusion Transmitted Diseases (DETTD), Office of Blood Research and Review (OBRR), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration(FDA), Bethesda, Maryland; Source Info: Apr2006, Vol. 46 Issue 4, p659; Subject Term: WEST Nile virus; Subject Term: VIRAL replication; Subject Term: BLOOD transfusion; Subject Term: LANGERHANS cells; Subject Term: MONOCYTES; Subject Term: MACROPHAGES; Subject Term: BLOOD donors; Subject Term: POLYMERASE chain reaction; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1537-2995.2006.00769.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20274267&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105849456
T1 - Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusion.
AU - Rios M
AU - Zhang MJ
AU - Grinev A
AU - Srinivasan K
AU - Daniel S
AU - Wood O
AU - Hewlett IK
AU - Dayton AI
Y1 - 2006/04//
N1 - Accession Number: 105849456. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Blood Transfusion -- Adverse Effects
KW - Flaviviridae
KW - Macrophages
KW - Monocytes
KW - West Nile Fever -- Prevention and Control
KW - West Nile Fever -- Transmission
KW - Cells
KW - DNA Probes
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - RNA
SP - 659
EP - 667
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 46
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND: West Nile virus (WNV) transmission by transfusion was documented in 2002. Approximately 80 percent of WNV infections are asymptomatic and 1 percent develop severe neurological illness. In animals, Langerhans-dendritic cells support initial viral replication, followed by replication in lymphoid tissues and dissemination to organs and possibly to the CNS. The cellular tropism of WNV infection after transfusion and the particular human blood cells that sustain viral replication remain largely unknown. Whether primary monocyte-derived macrophages (MDMs) support WNV infection-replication and produce infectious virions, with an in vitro system, was investigated. STUDY DESIGN AND METHODS: Elutriated monocytes (CD33+/CD14+) from suitable blood donors were cultured in the presence of macrophage-colony-stimulating factor, infected with WNV-NY99 at different time points, washed, and cultivated for up to 47 days. Supernatants were tested for WNV replication by TaqMan reverse transcription-polymerase chain reaction (RT-PCR), with primers for the envelope and/or 3'NC regions, and by cDNA-PCR to detect WNV minus-strand RNA and for the presence of functional virions by infectivity assays in Vero cells. RESULTS: RT-PCR TaqMan of supernatants demonstrated productive infection of MDMs. Viral load reached 2 to 5 log above baseline in 3 to 6 days and then declined, with detectable viral replication persisting for up to 47 days. WNV minus-strand RNA was detected in Day 4 cultures, indicating active viral replication. Infected MDM cultures showed no cytopathic changes. Supernatants that were TaqMan-positive for the presence of WNV-infected Vero cells and produced cytopathic effects within 3 to 5 days of culture. CONCLUSION: The susceptibility of monocytes-macrophages to productive infection in vitro is compatible with a potential role in initial WNV replication and propagation after transmission by transfusion.
SN - 0041-1132
AD - Laboratory of Molecular Virology (LMV), Division of Emerging Transfusion Transmitted Diseases (DETTD), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, MD 20892, USA. maria.rios@fda.hhs.gov
U2 - PMID: 16584445.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105849362
T1 - Transfusion-transmitted Klebsiella pneumoniae fatalities, 1995 to 2004.
AU - Niu MT
AU - Knippen M
AU - Simmons L
AU - Holness LG
Y1 - 2006/04//
N1 - Accession Number: 105849362. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8709027.
KW - Blood Transfusion -- Adverse Effects
KW - Klebsiella Infections -- Mortality
KW - Klebsiella Infections -- Transmission
KW - Klebsiella
KW - Adult
KW - Aged
KW - Fatal Outcome
KW - Female
KW - Male
KW - Middle Age
KW - Platelet Transfusion
SP - 149
EP - 157
JO - Transfusion Medicine Reviews
JF - Transfusion Medicine Reviews
JA - TRANSFUS MED REV
VL - 20
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Transfusion-transmitted bacterial sepsis is the third most common cause of transfusion-related fatalities reported to the Food and Drug Administration. Between October 1, 1995, and September 30, 2004, there were 665 reported transfusion fatalities. Eighty-five (13%) deaths were due to transfusion-transmitted bacterial infections, of which 58 (68%) were due to gram-negative organisms. The most common gram-negative organism associated with transfusion-transmitted deaths after receipt of platelets was Klebsiella pneumoniae. This article summarizes retrospectively the case series of deaths due to transfusion-transmitted K pneumoniae infection, reported to the Food and Drug Administration, 1995 to 2004. There were 12 deaths due to transfusion-transmitted K pneumoniae infection with 7 (58%) of the 12 cases occurring in 2002. Eleven deaths were caused by the transfusion of contaminated platelets and 1 death attributed to contaminated red blood cells. Extensive review of the seven 2002 fatality reports did not identify a common (shared) lot for items used during collection or processing of the blood product. In conclusion, in cases of suspected transfusion-transmitted septicemia, broad spectrum antibiotic coverage including coverage of gram-negative organisms should be considered. Strict adherence to infection control measures while collecting, processing, and handling all blood and blood components in both the clinical settings and in the laboratory should be followed. Further development of simple and effective test procedures for detecting bacteria in the blood is needed.Copyright © 2006 by Elsevier Inc.
SN - 0887-7963
AD - Division of Blood Applications, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852-1448, USA. niu@cber.fda.gov
U2 - PMID: 16565027.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-04415-006
AN - 2006-04415-006
AU - Mosholder, Andrew D.
AU - Willy, Mary
T1 - Suicidal adverse events in pediatric randomized, controlled clinical trials of antidepressant drugs are associated with active drug treatment: A meta-analysis.
JF - Journal of Child and Adolescent Psychopharmacology
JO - Journal of Child and Adolescent Psychopharmacology
JA - J Child Adolesc Psychopharmacol
Y1 - 2006/04//
VL - 16
IS - 1-2
SP - 25
EP - 32
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1044-5463
SN - 1557-8992
AD - Mosholder, Andrew D., FDA Division of Drug Risk Evaluation, Office of Drug Safety, 10903 New Hampshire Ave., Mail Stop 3411, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2006-04415-006. PMID: 16553526 Partial author list: First Author & Affiliation: Mosholder, Andrew D.; Division of Drug Risk Evaluation, Office of Drug Safety, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20060428. Correction Date: 20110620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Drug Therapy; Pediatrics; Suicidal Ideation. Minor Descriptor: Major Depression. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Methodology: Meta Analysis. References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2006.
AB - Objective: The aim of this study was to compare the incidence of suicidal ideation and behaviors observed with antidepressant drug treatment to the incidence with placebo, in randomized, controlled pediatric clinical trials. Methods: Manufacturers of nine antidepressant drugs identified suicidal adverse events in randomized, placebo-controlled, pediatric clinical trials that they had sponsored. Events were found with an electronic search for adverse event descriptions, including key words suggesting suicidal ideation or self-injury, along with a manual review of all adverse events meeting the standard regulatory definition for seriousness. Incidence rate data for these events supplied by the manufacturers were combined across trials to yield Mantel-Haenszel combined risk estimates. Results: Data from 22 randomized, short-term, placebo-controlled, pediatric trials in various indications, involving nine different antidepressant drugs, were available for analysis. A total of 2298 pediatric subjects were exposed to active drug, and 1952 to placebo. Seventy-eight (78) serious suicidal adverse events occurred in these trials (54 with active drug and 24 with placebo); there were no completed suicides. The combined incidence rate ratio across all trials for serious suicidal adverse events was 1.89 (95% Confidence Interval, 1.18-3.04). Conclusions: In short-term, placebo-controlled, pediatric studies of antidepressants, active drug treatment was associated with a rate of serious suicidal events almost twice that of placebo. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicidal ideation
KW - pediatrics
KW - drug treatment
KW - antidepressant drugs
KW - depression
KW - 2006
KW - Antidepressant Drugs
KW - Drug Therapy
KW - Pediatrics
KW - Suicidal Ideation
KW - Major Depression
KW - 2006
DO - 10.1089/cap.2006.16.25
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04415-006&site=ehost-live&scope=site
UR - andrew.mosholder@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04415-007
AN - 2006-04415-007
AU - Mosholder, Andrew D.
AU - Pamer, Carol A.
T1 - Postmarketing surveillance of suicidal adverse events with pediatric use of antidepressants.
JF - Journal of Child and Adolescent Psychopharmacology
JO - Journal of Child and Adolescent Psychopharmacology
JA - J Child Adolesc Psychopharmacol
Y1 - 2006/04//
VL - 16
IS - 1-2
SP - 33
EP - 36
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1044-5463
SN - 1557-8992
AD - Mosholder, Andrew D., FDA Division of Drug Risk Evaluation, Office of Drug Safety, 10903 New Hampshire Ave., Mail Stop 3411, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2006-04415-007. PMID: 16553527 Partial author list: First Author & Affiliation: Mosholder, Andrew D.; Division of Drug Risk Evaluation, Office of Drug Safety, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20060428. Correction Date: 20110620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Drug Therapy; Pediatrics; Suicidal Ideation; Suicide. Minor Descriptor: Side Effects (Drug); Trends. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Apr, 2006.
AB - Objective: The aim of this analysis was to delineate trends in spontaneous postmarketing reporting data with antidepressant drugs for adverse events involving suicidal behaviors in children and adolescents. Methods: The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) was searched for postmarketing adverse event reports of suicidal thoughts and behaviors occurring in children and adolescents treated with 10 antidepressant drugs. The search covered the period from market launch of each drug through November 2003. Results: A total of 524 reports were returned by the search. All drugs had reports, and most drugs demonstrated 15 or fewer reports annually, with the following two exceptions. We observed a peak of reporting for fluoxetine in the early 1990s, and another peak of reporting for paroxetine in recent years. Further investigation revealed that the peak in recent paroxetine reporting was accounted for by reports from consumers, whereas reporting by health professionals remained fairly constant. In contrast, the earlier peak in reports for fluoxetine was not accounted for by an increase in consumer reporting. Conclusions: Spontaneous reporting data for suicidal events in pediatric patients treated with antidepressant drugs appears to be highly variable and subject to various influences. The most appropriate method to assess an association of antidepressant drug treatment with suicidal behaviors is examination of systematically collected data with appropriate comparison groups, such as randomized, controlled trial data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antidepressant drugs
KW - suicidal thoughts & behaviors
KW - postmarketing surveillance
KW - pediatrics
KW - drug side effects
KW - trends
KW - 2006
KW - Antidepressant Drugs
KW - Drug Therapy
KW - Pediatrics
KW - Suicidal Ideation
KW - Suicide
KW - Side Effects (Drug)
KW - Trends
KW - 2006
DO - 10.1089/cap.2006.16.33
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04415-007&site=ehost-live&scope=site
UR - andrew.mosholder@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-01289-002
AN - 2007-01289-002
AU - Charles, Luenda E.
AU - Burchfiel, Cecil M.
AU - Fekedulegn, Desta
AU - Kashon, Michael L.
AU - Ross, G. Webster
AU - Petrovitch, Helen
AU - Sanderson, Wayne T.
T1 - Occupational exposures and movement abnormalities among Japanese-American men: The Honolulu-Asia Aging Study.
JF - Neuroepidemiology
JO - Neuroepidemiology
JA - Neuroepidemiology
Y1 - 2006/04//
VL - 26
IS - 3
SP - 130
EP - 139
CY - Switzerland
PB - Karger
SN - 0251-5350
SN - 1423-0208
AD - Charles, Luenda E., National Institute for Occupational Safety and Health HELD/BED, MS L-4050, 1095 Willowdale Rd., Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2007-01289-002. PMID: 16439859 Partial author list: First Author & Affiliation: Charles, Luenda E.; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Release Date: 20070507. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Human Males; Metals; Movement Disorders; Occupational Exposure. Minor Descriptor: Cognitive Ability; Facial Expressions; Insecticides. Classification: Working Conditions & Industrial Safety (3670); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Cognitive Abilities Screening Index Instrument; Unified Parkinson Disease Rating Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 2006.
AB - Objective: The authors analyzed data on 1,049 men aged 71-93 years (excluding those with prevalent Parkinson's disease and stroke) from the Honolulu Heart Program (1965-1968) and the Honolulu-Asia Aging Study (1991-1999) to determine whether occupational exposures to pesticides, solvents, metals, manganese, and mercury during middle age were associated with 14 movement abnormalities 25 years later. Methods: Analyses of variance and multivariate logistic regression were used to assess associations of interest. Results: After adjustment for age, BMI, cognitive functioning, smoking, alcohol drinking, education, and physical activity, there was a positive association between abnormal 'facial expression' and the highest exposure to metals [odds ratio (OR) = 2.62; 95% confidence interval (CD = 1.35-5.11; trend, p = 0.02], and the highest exposure to mercury (OR = 1.91; 95% CI = 1.04-3.49; trend, p = 0.03). Age was positively associated with all movement abnormalities, and cognitive function, body mass index and physical activity were inversely associated with most movement abnormalities. Conclusion: Higher exposure to any metal, and specifically mercury, was associated with abnormal facial expression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - occupational exposures
KW - movement abnormalities
KW - Japanese American men
KW - metals
KW - abnormal facial expression
KW - 2006
KW - Aging
KW - Human Males
KW - Metals
KW - Movement Disorders
KW - Occupational Exposure
KW - Cognitive Ability
KW - Facial Expressions
KW - Insecticides
KW - 2006
U1 - Sponsor: US Department of the Army, US. Grant: DAMD17-98-1-8621. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute on Aging. Grant: N01-AG-4-2149; 1-RO1-AG1715 5-01A1. Recipients: No recipient indicated
U1 - Sponsor: National Heart, Lung, and Blood Institute. Grant: N01-HC-05102. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Neurological Disorders and Stroke. Grant: 1-R01-NS41265-01. Recipients: No recipient indicated
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: HELD0080060. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, Office of Research and Development, Medical Research Service, US. Recipients: No recipient indicated
DO - 10.1159/000091178
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-01289-002&site=ehost-live&scope=site
UR - lcharles@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07535-003
AN - 2006-07535-003
AU - Burke-Miller, Jane K.
AU - Cook, Judith A.
AU - Grey, Dennis D.
AU - Razzano, Lisa A.
AU - Blyler, Crystal R.
AU - Leff, H. Stephen
AU - Gold, Paul B.
AU - Goldberg, Richard W.
AU - Mueser, Kim T.
AU - Cook, William L.
AU - Hoppe, Sue K.
AU - Stewart, Michelle
AU - Blankertz, Laura
AU - Dudek, Kenn
AU - Taylor, Amanda L.
AU - Carey, Martha Ann
T1 - Demographic Characteristics and Employment Among People with Severe Mental Illness in a Multisite Study.
JF - Community Mental Health Journal
JO - Community Mental Health Journal
JA - Community Ment Health J
Y1 - 2006/04//
VL - 42
IS - 2
SP - 143
EP - 159
CY - Germany
PB - Springer
SN - 0010-3853
SN - 1573-2789
AD - Burke-Miller, Jane K., Center on Mental Health Services Research and Policy, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2006-07535-003. PMID: 16404685 Partial author list: First Author & Affiliation: Burke-Miller, Jane K.; Center on Mental Health Services Research and Policy, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20060705. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Employment Status; Mental Disorders. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Apr, 2006.
AB - People with psychiatric disabilities experience disproportionately high rates of unemployment. As research evidence is mounting regarding effective vocational programs, interest is growing in identifying subgroup variations. Data from a multisite research and demonstration program were analyzed to identify demographic characteristics associated with employment outcomes, after adjusting for the effects of program, services, and study site. Longitudinal analyses found that people with more recent work history, younger age, and higher education were more likely to achieve competitive employment and to work more hours per month, while race and gender effects varied by employment outcome. Results provide strong evidence of demographic subgroup variation and need. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - demographic characteristics
KW - employment
KW - severe mental illness
KW - 2006
KW - Demographic Characteristics
KW - Employment Status
KW - Mental Disorders
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: Cooperative Agreement SM51820. Other Details: Employment Intervention Demonstration Program (EIDP). Recipients: No recipient indicated
DO - 10.1007/s10597-005-9017-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07535-003&site=ehost-live&scope=site
UR - Jburke@psych.uic.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10053-004
AN - 2006-10053-004
AU - Rimondini, Michela
AU - Del Piccolo, Lidia
AU - Goss, Claudia
AU - Mazzi, Mariangela
AU - Paccaloni, Monica
AU - Zimmermann, Christa
T1 - Communication Skills in Psychiatry Residents--How Do They Handle Patient Concerns?
JF - Psychotherapy and Psychosomatics
JO - Psychotherapy and Psychosomatics
JA - Psychother Psychosom
Y1 - 2006/04//
VL - 75
IS - 3
SP - 161
EP - 169
CY - Switzerland
PB - Karger
SN - 0033-3190
SN - 1423-0348
AD - Zimmermann, Christa, Dipartimento di Medicina e Sanita Pubblica, Servizio di Psicologia Medica, Universita di Verona, Policlinico G.B. Rossi, Piazzale L.A. Scuro 10, IT-37134, Verona, Italy
N1 - Accession Number: 2006-10053-004. PMID: 16636631 Other Journal Title: Acta Psychotherapeutica. Partial author list: First Author & Affiliation: Rimondini, Michela; Department of Medicine and Public Health, Service of Medical Psychology, University of Verona, Verona, Italy. Release Date: 20060828. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communication Skills; Emotional States; Psychiatrists; Psychotherapeutic Processes. Minor Descriptor: Psychiatric Patients; Psychiatry. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: Italy. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Verona Psychiatric Interview Classification System. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 2006.
AB - Background: The main focus of the training of psychiatrists is on diagnosis and treatment based on the traditional doctor-centered approach to the psychiatric interview. Less attention is given to the correct handling of patients' emotional concerns, which is crucial for the patient-physician relationship, but also for improving diagnostic and treatment decisions. The aim of this study is to assess psychiatrists' responses to patients' concerns and worries. Method: 118 consultations, conducted by 10 residents in psychiatry with 20 simulated patients, have been coded using the Verona Psychiatric Interview Classification System. Lag1 sequential analysis and a multinomial logit regression analysis were performed to investigate the relationship between patients' expressions of concern and psychiatrists' subsequent interventions in terms of patient-centered skills. Results: Compared to doctor-centered interventions, all patients' expressions of concern increased the probability of passive listening (odds ratios between 2.4 and 4.2). They also increased the occurrence of emotion focusing interventions (odds ratios between 3.3 and 1.7), which however remained rare (4% of residents' total responses). A small although significant increase in the likelihood of active listening expressions was observed as a response to two types of patient expressions of concern: statements of feelings (odds ratio 1.4) and expression of opinions regarding problematic psychosocial issues (odds ratio of 1.7). Conclusions: Young psychiatrists are good passive listeners but need to improve active listening skills which, together with emotion focusing skills, should be a major learning target in psychiatry. These patient-centered interviewing skills should integrate those traditionally used for attributing ICD-10 and/or DSM-IV categories. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - communication skills
KW - psychiatry residents
KW - patients' emotional concerns
KW - patient physician relationship
KW - psychiatrists' responses
KW - 2006
KW - Communication Skills
KW - Emotional States
KW - Psychiatrists
KW - Psychotherapeutic Processes
KW - Psychiatric Patients
KW - Psychiatry
KW - 2006
DO - 10.1159/000091773
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10053-004&site=ehost-live&scope=site
UR - Christa.Zimmermann@univr.it
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04860-017
AN - 2006-04860-017
AU - Hammad, Tarek A.
AU - Laughren, Thomas P.
AU - Racoosin, Judith A.
T1 - Suicide rates in short-term randomized controlled trials of newer antidepressants.
JF - Journal of Clinical Psychopharmacology
JO - Journal of Clinical Psychopharmacology
JA - J Clin Psychopharmacol
Y1 - 2006/04//
VL - 26
IS - 2
SP - 203
EP - 207
CY - US
PB - Lippincott Williams & Wilkins
SN - 0271-0749
SN - 1533-712X
AD - Hammad, Tarek A., Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2006-04860-017. PMID: 16633153 Partial author list: First Author & Affiliation: Hammad, Tarek A.; Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, US. Release Date: 20060522. Correction Date: 20120723. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Clinical Trials; Major Depression; Placebo; Suicide. Minor Descriptor: Drug Therapy; Side Effects (Drug). Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Hamilton Rating Scale for Depression DOI: 10.1037/t04100-000; Clinical Global Impression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2006.
AB - Concerns have been raised about the appropriateness of placebo controls in clinical trials for major depressive disorder (MDD), given that there are approved treatments for this illness. Critics have argued that patients with untreated depression would be exposed to an unnecessary risk of suicide. There is also a competing concern that antidepressant drug treatment itself may induce suicidal behavior and thinking (suicidality). To examine this question, we have evaluated the rate of suicide in placebo- and active drug-treated groups of patients with MDD and various anxiety disorders participating in short-term randomized controlled trials (RCTs). We examined data from all manufacturer-sponsored short-term RCTs of 9 commonly used antidepressants in patients with MDD and various anxiety disorders. All short-term RCTs of antidepressants in patients with MDD and various anxiety disorders were included. Individual patients' data were available for all trials. Data were available for the 207 trials conducted in patients with MDD, including a total of 40,028 patients. There were 21 cases of suicide in these patients. Forty-four trials were conducted in patients with various anxiety disorders, including a total of 10,972 patients. There were 2 cases of suicide in these patients. Overall, at least 1 case of suicide occurred in 21 of the 251 trials. Sixteen of the suicides in MDD trials occurred in trials that had only an active control comparison group, and most of these (14 cases) were observed in the non-North American trials. In the placebo-controlled MDD trials, the rate ratios of suicide in the combined drug groups compared with placebo were 1.07 (0.1-63.4) and 0.5 (0.0-36.7) for the non-North American and North American trials, respectively. In the anxiety disorder studies, the overall rate ratio of suicide for the selective serotonin reuptake inhibitors compared with placebo was 0.9 (0.0-71.4). Neither use of placebo nor of antidepressants in short-term RCTs was associated with an increased risk of completed suicide among patients with MDD or various anxiety disorders. Nonetheless, because of the small numbers of suicides in these trials and the subsequent lack of statistical power, an increased risk of completed suicide in association with either drug or placebo treatment cannot be definitively excluded. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide rates
KW - short-term randomized controlled trials
KW - newer antidepressants
KW - major depressive disorder
KW - placebo treatment
KW - suicidal behavior
KW - 2006
KW - Antidepressant Drugs
KW - Clinical Trials
KW - Major Depression
KW - Placebo
KW - Suicide
KW - Drug Therapy
KW - Side Effects (Drug)
KW - 2006
DO - 10.1097/01.jcp.0000203198.11453.95
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04860-017&site=ehost-live&scope=site
UR - hammadt@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06993-002
AN - 2006-06993-002
AU - Flattery, Jennifer
AU - Davis, Letitia
AU - Rosenman, Kenneth D.
AU - Harrison, Robert
AU - Lyon-Callo, Sarah
AU - Filios, Margaret
T1 - The Proportion of Self-Reported Asthma Associated with Work in Three States: California, Massachusetts, and Michigan, 2001.
JF - Journal of Asthma
JO - Journal of Asthma
JA - J Asthma
Y1 - 2006/04//
VL - 43
IS - 3
SP - 213
EP - 218
CY - United Kingdom
PB - Taylor & Francis
SN - 0277-0903
SN - 1532-4303
AD - Flattery, Jennifer, California Department of Health Services, Occupational Health Branch, 850 Marina Bay Parkway, Building P, 3rd Floor, Richmond, CA, US, 94804-6403
N1 - Accession Number: 2006-06993-002. PMID: 16754524 Other Journal Title: Journal of Asthma Research. Partial author list: First Author & Affiliation: Flattery, Jennifer; California Department of Health Services, Richmond, CA, US. Other Publishers: Informa Healthcare. Release Date: 20061120. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Asthma; Self-Report; Working Conditions. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 2006.
AB - Objectives: To assess the proportion of adult asthma at the state level that may be related to work. Design: Work-related asthma questions were added to the 2001 Behavioral Risk Factor Surveillance System (BRFSS) questionnaire in California, Massachusetts, and Michigan. Results: Findings indicate 7.4-9.7% of those with current asthma reported that their asthma may be work related. These results estimate that approximately 137,000 adults in California, 39,000 in Massachusetts, and 63,000 in Michigan have asthma that may be work related. Conclusions: These findings are unique in providing population-based estimates at the state level that illustrate that a substantial portion of adult asthma morbidity is due to exposures in the work environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self reported asthma
KW - California
KW - Massachusetts
KW - Michigan
KW - working conditions
KW - 2006
KW - Asthma
KW - Self-Report
KW - Working Conditions
KW - 2006
DO - 10.1080/02770900600566967
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06993-002&site=ehost-live&scope=site
UR - jflatter@dhs.ca.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-05923-007
AN - 2007-05923-007
AU - Laughren, Thomas
AU - Levin, Robert
T1 - Food and Drug Administration perspective on negative symptoms in schizophrenia as a target for a drug treatment claim.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 2006/04//
VL - 32
IS - 2
SP - 220
EP - 222
CY - United Kingdom
PB - Oxford University Press
SN - 0586-7614
SN - 1745-1701
AD - Laughren, Thomas, Food and Drug Administration, DNDP, (HFD-120), 5600 Fishers Lane, Rockville, MD, US, 20853
N1 - Accession Number: 2007-05923-007. PMID: 16079389 Partial author list: First Author & Affiliation: Laughren, Thomas; Food and Drug Administration, DNDP, Rockville, MD, US. Other Publishers: National Institute of Mental Health. Release Date: 20070514. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Drugs; Government Agencies; Positive and Negative Symptoms; Schizophrenia. Classification: Schizophrenia & Psychotic States (3213); Clinical Psychopharmacology (3340). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Apr, 2006.
AB - Negative symptoms of schizophrenia are not adequately addressed by available treatments for schizophrenia. Thus, it is reasonable to consider them as a target for a drug claim. This article describes the thought process that the Food and Drug Administration (FDA) will undertake in considering negative symptoms of schizophrenia as a novel and distinct drug target. Beyond this basic question, this article identifies a number of design issues that the FDA needs to consider regarding how best to conduct studies to support claims for this target. These design issues include (1) what population to study, (2) what phase of illness to target, (3) whether to focus on the negative symptom domain overall or on some specific aspect of negative symptoms, (4) the role of functional measures in negative symptom trials, and (5) optimal designs for targeting drugs for add-on therapy or broad-spectrum agents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Food and Drug Administration
KW - negative symptoms
KW - schizophrenia
KW - drug treatment claim
KW - 2006
KW - Drug Therapy
KW - Drugs
KW - Government Agencies
KW - Positive and Negative Symptoms
KW - Schizophrenia
KW - 2006
DO - 10.1093/schbul/sbi039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-05923-007&site=ehost-live&scope=site
UR - laughren@cder.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10404-007
AN - 2006-10404-007
AU - Nicholson, Joanne
AU - Finkelstein, Norma
AU - Williams, Valerie
AU - Thom, Jennifer
AU - Noether, Chanson
AU - DeVilbiss, Megan
T1 - A Comparison of Mothers with Co-occurring Disorders and Histories of Violence Living with or Separated from Minor Children.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2006/04//
VL - 33
IS - 2
SP - 225
EP - 243
CY - Germany
PB - Springer
SN - 1094-3412
AD - Nicholson, Joanne, Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-10404-007. PMID: 16645909 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Nicholson, Joanne; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20061010. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Child Care; Childhood Development; Comorbidity; Mother Child Relations; Mothers. Minor Descriptor: Violence. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Global Severity Index; Posttraumatic Stress Disorder Symptom Scale-Interview Version; Behavior and Symptom Identification Scale; SF-12; Life Stressor Checklist--Revised DOI: 10.1037/t04534-000; Addiction Severity Index DOI: 10.1037/t00025-000; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Apr, 2006.
AB - Data from the Women with Co-occurring Disorders and Histories of Violence Study are used to examine characteristics distinguishing mothers currently providing care for all their minor children (n = 558) from mothers separated from one or more minor children (n = 1396). Mothers are described and compared on background characteristics and experiences, well-being and current functioning, situational context, and services used. Analyses control for number of children, race, and years of education. Mothers separated from children have more children, less education, have more often been homeless, in juvenile detention or jail, and have lower incomes than mothers living with all their children. Mothers separated from children have more extensive experiences of traumatic and stressful life events, and the groups differ in current functioning and patterns of services used. While cross-sectional data do not allow causal inferences, challenges faced by mothers have significant implications for policy and programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mothers
KW - violence
KW - minor children
KW - separation
KW - co-occurring disorders
KW - child care
KW - 2006
KW - Child Care
KW - Childhood Development
KW - Comorbidity
KW - Mother Child Relations
KW - Mothers
KW - Violence
KW - 2006
U1 - Sponsor: US Department of Health and Human Services, Public Health Service, Substance Abuse and Mental Health Services Administration. Other Details: This study was funded under Guidance for Applicants (GFA) No. TI 00-003 entitled Cooperative Agreement to Study Women with Alcohol, Drug Abuse and Mental Health (ADM Disorders who have Histories of Violence: Phase II); Center for Substance Abuse Treatment, Center for Mental Health Services, and Center for Substance Abuse Prevention (March 2000).. Recipients: No recipient indicated
DO - 10.1007/s11414-006-9015-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10404-007&site=ehost-live&scope=site
UR - mdevilbiss@ahinc.org
UR - cnoether@prainc.com
UR - jennifert@etr.org
UR - Valerie.Williams@Umassmed.edu
UR - normafinkelstein@healthrecovery.org
UR - Joanne.Nicholson@Umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10404-008
AN - 2006-10404-008
AU - Walrath, Christine M.
AU - Sheehan, Angela K.
AU - Holden, E. Wayne
AU - Hernandez, Mario
AU - Blau, Gary M.
T1 - Evidence-based Treatments in the Field: A Brief Report on Provider Knowledge, Implementation, and Practice.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2006/04//
VL - 33
IS - 2
SP - 244
EP - 253
CY - Germany
PB - Springer
SN - 1094-3412
AD - Walrath, Christine M., ORC Macro, 116 John Street, Suite 800, New York, NY, US, 10038
N1 - Accession Number: 2006-10404-008. PMID: 16645910 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Walrath, Christine M.; ORC Macro, New York, NY, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20061010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Evidence Based Practice; Mental Health Services; Service Personnel; Treatment Effectiveness Evaluation. Minor Descriptor: Childhood Development; Practice. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Evidence-Based Treatment Survey. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 2006.
AB - This study examined familiarity, perceived effectiveness, and implementation of evidence-based treatments for children in community settings. A sample of service providers in agencies affiliated with federal programs to improve children's mental health services was identified using a snowball sampling procedure. Forty-four percent of the sample (n = 616) responded to a Web-based survey designed to collect data on evidence-based treatments. High familiarity with, relatively high-perceived effectiveness, and generally high use of evidence-based treatments were reported. Partial implementation of treatment protocols within the context of few agency mandates and widely ranging supports for the implementation of evidence-based treatments was found. Results support the inclusion of more complex models of diffusion, dissemination and implementation in research, and development efforts for evidence-based treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evidence based treatments
KW - community settings
KW - service providers knowledge
KW - mental health services
KW - children
KW - treatment effectiveness evaluation
KW - practice
KW - 2006
KW - Communities
KW - Evidence Based Practice
KW - Mental Health Services
KW - Service Personnel
KW - Treatment Effectiveness Evaluation
KW - Childhood Development
KW - Practice
KW - 2006
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: 280-97-8014, 280-00-8040. Recipients: No recipient indicated
DO - 10.1007/s11414-005-9008-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10404-008&site=ehost-live&scope=site
UR - christine.m.walratli-greene@orcmacro.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10404-010
AN - 2006-10404-010
AU - Compagni, Amelia
AU - Manderscheid, Ronald W.
T1 - A Neuroscientist-Consumer Alliance to Transform Mental Health Care.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2006/04//
VL - 33
IS - 2
SP - 265
EP - 274
CY - Germany
PB - Springer
SN - 1094-3412
AD - Manderscheid, Ronald W., Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, MD, US, 20853
N1 - Accession Number: 2006-10404-010. PMID: 16645912 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Compagni, Amelia; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20061010. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; Neurobiology; Pharmacology; Therapeutic Alliance. Minor Descriptor: Mental Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10). Supplemental Data: Other Appended. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 2006.
AB - The field of mental health has long suffered from a lack of convergence of disciplines that deal with the mind, the brain, and behavior. This mind-brain dualism has been particularly detrimental for consumers and their families who daily face stigma and discrimination. The understanding of the brain and its dysfunctions has benefited from the study of the human genome and, in particular, of the mutations and variations in its code. This analysis permits a better understanding of the biological basis of mental disease and will soon inform a generation of new diagnostic tools and individualized pharmacological therapies. A biological perspective on mental illness will be complemented by the analysis of the social factors influencing people's behavior and their impact on brain biology and gene function. Neurobiology has progressed to a level for which the knowledge that is generated, even if still colored with uncertainty, could represent a catalyst for the creation of an alliance between neuroscientists and consumers. This partnership has the potential to benefit both parties but will require some concrete steps that might be outside of the usual courses of action for both consumers and scientists. It is by building collaborations based on personal contact and information sharing that a transformation of the mental health care system can occur. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - neuroscientist consumer alliance
KW - consumers
KW - biological basis
KW - mental diseases
KW - pharmacological therapies
KW - neurobiology
KW - 2006
KW - Mental Health Services
KW - Neurobiology
KW - Pharmacology
KW - Therapeutic Alliance
KW - Mental Disorders
KW - 2006
DO - 10.1007/s11414-006-9011-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10404-010&site=ehost-live&scope=site
UR - mander5@covad.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04821-007
AN - 2006-04821-007
AU - Jaffe, Benjamin D.
AU - Evans, Theodore A.
AU - Howell, Sue
AU - Westergaard, Gregory C.
AU - Snoy, Philip J.
AU - Higley, J. Dee
T1 - Left versus right nipple preference in free-ranging infant rhesus macaques (Macaca mulatta).
JF - Developmental Psychobiology
JO - Developmental Psychobiology
JA - Dev Psychobiol
Y1 - 2006/04//
VL - 48
IS - 3
SP - 266
EP - 272
CY - US
PB - John Wiley & Sons
SN - 0012-1630
SN - 1098-2302
AD - Howell, Sue, Alpha Genesis, Inc., 95 Castle Hall Road, P.O. Box 557, Yemassee, SC, US, 29945
N1 - Accession Number: 2006-04821-007. PMID: 16568413 Partial author list: First Author & Affiliation: Jaffe, Benjamin D.; Alpha Genesis, Inc., Yemassee, SC, US. Release Date: 20060530. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Animal Environments; Breast Feeding; Infants (Animal); Lateral Dominance; Primates (Nonhuman). Minor Descriptor: Animal Development; Animal Maternal Behavior; Preferences. Classification: Social & Instinctive Behavior (2440). Population: Animal (20); Male (30); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2006.
AB - The examination of nonhuman primate (NHP) lateralized behaviors may provide insight into the evolution of hemispheric specialization. This study examined nipple preference in 64 infant macaques in order to consider the ontogeny of lateralized behavior. We used a focal animal sampling method to record nipple contact during 15, 30-min observation sessions collected across each infant's first year of life. Using a lateralized behavior index (LBI) we calculated individual and population preferences (LBI = (R - L)/(R + L); 'R' = mean right nipple contact, 'L' = mean left nipple contact). Strength of preference was calculated as the absolute value of this score. Infants exhibited no population preference for a particular nipple, but showed a significant strength of preference that developed after 48 hr. Interestingly, successive siblings preferred the nipple not used by the previous infant. These findings suggest that nipple preference is guided by external stimuli, and that nipple preference during infancy may not be a behavioral representation of hemispheric specialization. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - right nipple preference
KW - rhesus macaques
KW - nonhuman primate
KW - hemispheric specialization
KW - ontogeny
KW - 2006
KW - Animal Environments
KW - Breast Feeding
KW - Infants (Animal)
KW - Lateral Dominance
KW - Primates (Nonhuman)
KW - Animal Development
KW - Animal Maternal Behavior
KW - Preferences
KW - 2006
U1 - Sponsor: Food and Drug Administration. Grant: 223-01-1101. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism. Grant: N01AA02018. Recipients: No recipient indicated
DO - 10.1002/dev.20128
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04821-007&site=ehost-live&scope=site
UR - suehowell@alphagenesisinc.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03649-002
AN - 2006-03649-002
AU - Morré, Servaas A.
AU - Spaargaren, Joke
AU - Veldhuijzen, Irene K.
AU - Postma, Maarten J.
AU - van Bergen, Jan E. A. M.
T1 - Evaluation of the leukocyte esterase test (LET) as pre-screening test to reduce costs for national population-based Chlamydia trachomatis screening programs.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2006/04//
VL - 38
IS - 4
SP - 332
EP - 333
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
N1 - Accession Number: 2006-03649-002. PMID: 16549289 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Morré, Servaas A.; Laboratory of Immunogenetics, Section Immunogenetics of Infectious Diseases, VU University Medical Center, Amsterdam, Netherlands. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Leucocytes; Medical Diagnosis; Nucleic Acids; Sexually Transmitted Diseases. Minor Descriptor: Esterases. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Apr, 2006.
AB - Comments on the article by Blake et al. (see record [rid]2005-03211-009[/rid]). With great interest, we read the article by Blake and colleagues on the re-evaluation and potential re-appreciation of the Leukocyte Esterase Test (LET) as an initial screening test to be followed by nucleic acid amplification testing (NAAT) confirmation. We too have recently evaluated the inexpensive LET as compared with commercial polymerase chain reaction (PCR) detection of Chlamydia trachomatis to prescreen urine samples obtained from an asymptomatic population. The time between urine sampling (home obtained) and LET testing (one to seven days) did not influence the identification of the number of C. trachomatis DNA-positive subjects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - leukocyte esterase
KW - chlamydia detection
KW - nucleic acid amplification test
KW - medical diagnosis
KW - 2006
KW - Leucocytes
KW - Medical Diagnosis
KW - Nucleic Acids
KW - Sexually Transmitted Diseases
KW - Esterases
KW - 2006
DO - 10.1016/j.jadohealth.2005.11.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03649-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04381-010
AN - 2006-04381-010
AU - Chen, Hongtu
AU - Coakley, Eugenie H.
AU - Cheal, Karen
AU - Maxwell, James
AU - Costantino, Giuseppe
AU - Krahn, Dean D.
AU - Malgady, Robert G.
AU - Durai, U. Nalla B.
AU - Quijano, Louise M.
AU - Zaman, Saminaz
AU - Miller, Christopher J.
AU - Ware, James H.
AU - Chung, Henry
AU - Aoyama, Carolyn
AU - Van Stone, William W.
AU - Levkoff, Sue E.
T1 - Satisfaction with mental health services in older primary care patients.
JF - The American Journal of Geriatric Psychiatry
JO - The American Journal of Geriatric Psychiatry
JA - Am J Geriatr Psychiatry
Y1 - 2006/04//
VL - 14
IS - 4
SP - 371
EP - 379
CY - US
PB - Lippincott Williams & Wilkins
SN - 1064-7481
SN - 1545-7214
AD - Chen, Hongtu, Department of Psychiatry, Brigham and Women's Hospital, 1249 Boylston St., 3rd Floor, Boston, MA, US, 02215
N1 - Accession Number: 2006-04381-010. PMID: 16582046 Partial author list: First Author & Affiliation: Chen, Hongtu; Department of Psychiatry, Harvard Medical School, Boston, MA, US. Other Publishers: Elsevier Science. Release Date: 20060522. Correction Date: 20130715. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Satisfaction; Geriatric Patients; Major Depression; Mental Health Services. Minor Descriptor: Health Care Psychology; Primary Health Care. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Short Michigan Alcohol Screening Test; General Health Questionnaire; SF-36 Health Survey; Center for Epidemiologic Studies Depression Scale; Client Satisfaction Questionnaire; Mini International Neuropsychiatric Interview DOI: 10.1037/t18597-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 2006.
AB - Objective: This study examines whether older adult primary care patients are satisfied with two intervention models designed to ameliorate their behavioral health problems. Methods: A total of 1,052 primary care patients aged 65 and older with depression, anxiety, or at-risk drinking were randomly assigned to and participated in either integrated care (IC) or enhanced specialty referral (ESR) model and completed the Client Satisfaction Questionnaire (CSQ) administered at three-month follow-up assessment. Results: Older adult patients' satisfaction with IC (mean: 3.4, standard deviation [SD]: 0.60) was significantly higher than that with ESR (mean: 3.2, SD: 0.78), but the absolute difference was modest. Regression results showed that patients who used the IC model, attended the treatment service twice or more, or showed clinical improvement were more likely to express greater satisfaction. Stigma toward mental illness was negatively associated with satisfaction with mental health services. Conclusions: Older adults are more likely to have greater satisfaction with mental health services integrated in primary care settings than through enhanced referrals to specialty mental health and substance abuse clinics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - primary care patient
KW - patients satisfaction
KW - older adults
KW - 2006
KW - Client Satisfaction
KW - Geriatric Patients
KW - Major Depression
KW - Mental Health Services
KW - Health Care Psychology
KW - Primary Health Care
KW - 2006
U1 - Sponsor: US Department of Veterans Affairs, US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Medicare and Medicaid Services (CMS). Recipients: No recipient indicated
DO - 10.1097/01.JGP.0000196632.65375.b9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04381-010&site=ehost-live&scope=site
UR - htchen@rics.bwh.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04071-007
AN - 2006-04071-007
AU - Harris, Katherine M.
AU - Edlund, Mark J.
AU - Larson, Sharon L.
T1 - Religious involvement and the use of mental health care.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2006/04//
VL - 41
IS - 2
SP - 395
EP - 410
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Harris, Katherine M., Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2006-04071-007. PMID: 16584455 Partial author list: First Author & Affiliation: Harris, Katherine M.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060918. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Edlund, Mark J. Major Descriptor: Health Care Utilization; Mental Disorders; Mental Health Services; Religiosity; Religious Beliefs. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Apr, 2006.
AB - Objectives: To examine the association between religious involvement and mental health care use by adults age 18 or older with mental health problems. Methods: We used data from the 2001-2003 National Surveys on Drug Use and Health. We defined two subgroups with moderate (n = 49,902) and serious mental or emotional distress (n = 14,548). For each subgroup, we estimated a series of bivariate probit models of past year use of outpatient care and prescription medications using indicators of the frequency of religious service attendance and two measures of the strength and influence of religious beliefs as independent variables. Covariates included common Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, disorders symptoms, substance use and related disorders, self-rated health status, and sociodemographic characteristics. Results: Among those with moderate distress, we found some evidence of a positive relationship between religious service attendance and outpatient mental health care use and of a negative relationship between the importance of religious beliefs and outpatient use. Among those with serious distress, use of outpatient care and medication was more strongly associated with service attendance and with the importance of religious beliefs. By contrast, we found a negative association between outpatient use and the influence of religious beliefs on decisions. Conclusion: The positive relationship between religious service participation and service use for those with serious distress suggests that policy initiatives aimed at increasing the timely and appropriate use of mental health care may be able to build upon structures and referral processes that currently exist in many religious organizations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - religious beliefs
KW - religious involvement
KW - mental health care utilization
KW - mental disorders
KW - 2006
KW - Health Care Utilization
KW - Mental Disorders
KW - Mental Health Services
KW - Religiosity
KW - Religious Beliefs
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, Health Services Research and Development Services, US. Grant: RCD-03-036. Other Details: Research Career Development Award. Recipients: Edlund, Mark J.
DO - 10.1111/j.1475-6773.2006.00500.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04071-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03105-011
AN - 2006-03105-011
AU - Vincent, Gina M.
T1 - Psychopathy and Violence Risk Assessment in Youth.
JF - Child and Adolescent Psychiatric Clinics of North America
JO - Child and Adolescent Psychiatric Clinics of North America
JA - Child Adolesc Psychiatr Clin N Am
Y1 - 2006/04//
VL - 15
IS - 2
SP - 407
EP - 428
CY - Netherlands
PB - Elsevier Science
SN - 1056-4993
AD - Vincent, Gina M., Center for Mental Health Services Research, Law and Psychiatry Program, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, WSH 8B-21, Worcester, MA, US, 01655
N1 - Accession Number: 2006-03105-011. PMID: 16527663 Partial author list: First Author & Affiliation: Vincent, Gina M.; Center for Mental Health Services Research, Law and Psychiatry Program, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060403. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antisocial Personality Disorder; Forensic Evaluation; Juvenile Justice; Violence; Risk Assessment. Minor Descriptor: Psychopathy. Classification: Psychological & Physical Disorders (3200); Criminal Law & Adjudication (4230). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 22. Issue Publication Date: Apr, 2006.
AB - Requests for forensic evaluations about youths' risk of violence are on the rise. Assessments of risk of violence are important for both decision making in some juvenile justice procedures and for the prevention of chronic violent offending through appropriate interventions. Psychopathic personality disorder has received much attention as an indicator of the risk of violence and treatment resistance among youth, but there are significant concerns about the use of assessments of psychopathy in youth populations. This article reviews the utility and limitations of assessments of psychopathy in youth and describes other tools available for assessing the risk of violence in youth. The article concludes with recommendations for forensic evaluators based on current empiric evidence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathy
KW - violence risk assessment
KW - youth
KW - forensic evaluations
KW - juvenile justice
KW - 2006
KW - Antisocial Personality Disorder
KW - Forensic Evaluation
KW - Juvenile Justice
KW - Violence
KW - Risk Assessment
KW - Psychopathy
KW - 2006
DO - 10.1016/j.chc.2005.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03105-011&site=ehost-live&scope=site
UR - Gina.Vincent@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-03649-021
AN - 2006-03649-021
AU - Orbeta, Rebecca L.
AU - Overpeck, Mary D.
AU - Ramcharran, Darmendra
AU - Kogan, Michael D.
AU - Ledsky, Rebecca
T1 - High caffeine intake in adolescents: Associations with difficulty sleeping and feeling tired in the morning.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2006/04//
VL - 38
IS - 4
SP - 451
EP - 453
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Orbeta, Rebecca L., Health Resources and Services Administration, Maternal and Child Health Bureau, Office of Data and Information Management, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2006-03649-021. PMID: 16549311 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Orbeta, Rebecca L.; Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD, US. Release Date: 20060410. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Caffeine; Drug Usage; Fatigue; Sleep Deprivation. Classification: Psychosocial & Personality Development (2840); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Apr, 2006.
AB - The objective of this study was to examine the association between caffeine usage in U.S. adolescents and the frequency that feeling tired in the morning and having difficulty sleeping is reported. In this study we found that feeling tired in the morning and having difficulty sleeping was experienced more commonly in those adolescents that have a high intake of caffeine. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - caffeine usage
KW - American adolescents
KW - sleeping difficulty
KW - morning tiredness
KW - 2006
KW - Adolescent Attitudes
KW - Caffeine
KW - Drug Usage
KW - Fatigue
KW - Sleep Deprivation
KW - 2006
DO - 10.1016/j.jadohealth.2005.05.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-03649-021&site=ehost-live&scope=site
UR - btingle76@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05002-003
AN - 2006-05002-003
AU - Cook, Judith A.
AU - Leff, H. Stephen
AU - Blyler, Crystal R.
AU - Gold, Paul B.
AU - Goldberg, Richard W.
AU - Clark, Robin E.
AU - Onken, Steven J.
AU - Shafer, Michael S.
AU - Blankertz, Laura E.
AU - McFarlane, William R.
AU - Razzano, Lisa A.
AU - Burke-Miller, Jane K.
T1 - Estimated payments to employment service providers for persons with mental illness in the Ticket to Work program.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/04//
VL - 57
IS - 4
SP - 465
EP - 471
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Cook, Judith A., Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL, US, 60615
N1 - Accession Number: 2006-05002-003. PMID: 16603740 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Cook, Judith A.; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20060710. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Disabilities; Employee Assistance Programs; Employee Motivation; Mental Disorders; Vocational Rehabilitation. Minor Descriptor: Incentives; Industrial and Organizational Psychology. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2006.
AB - Objective: The Ticket to Work and Work Incentives Improvement Act of 1999 removes work disincentives and promotes access to vocational services for people with disabilities. This study calculated the amount of payments that would have been made to employment service providers if study participants had been enrolled in the Ticket program. Methods: Data were from 450 Social Security Disability Insurance beneficiaries with psychiatric disabilities enrolled in a multisite study of supported employment. Earnings over two years were used to calculate provider payments under two reimbursement formulas used in the Ticket program. Results: Only a quarter of service recipients (26 percent) reached earnings levels that would have triggered provider payments under the first reimbursement formula. Only 4 percent would have completed their trial work period and left the rolls, generating payments under the second formula. Conclusions: The current provider payment systems of the Ticket to Work program do not reflect the reality of rehabilitation for individuals with severe mental illness. Reforms should take into account outcomes of return-to-work services for this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment service providers
KW - mental illness
KW - provider payments
KW - Ticket to Work
KW - work disincentives
KW - service recipients
KW - work incentives
KW - return to work services
KW - 2006
KW - Disabilities
KW - Employee Assistance Programs
KW - Employee Motivation
KW - Mental Disorders
KW - Vocational Rehabilitation
KW - Incentives
KW - Industrial and Organizational Psychology
KW - 2006
U1 - Sponsor: US Department of Education, National Institute on Disability and Rehabilitation Research, US. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: Cooperative agreement H133 B050003. Recipients: No recipient indicated
DO - 10.1176/appi.ps.57.4.465
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05002-003&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04072-014
AN - 2006-04072-014
AU - Savin, Daniel
AU - Garry, Mark T.
AU - Zuccaro, Paula
AU - Novins, Douglas
T1 - Telepsychiatry for treating rural American Indian Youth.
JF - Journal of the American Academy of Child & Adolescent Psychiatry
JO - Journal of the American Academy of Child & Adolescent Psychiatry
JA - J Am Acad Child Adolesc Psychiatry
Y1 - 2006/04//
VL - 45
IS - 4
SP - 484
EP - 488
CY - US
PB - Lippincott Williams & Wilkins
SN - 0890-8567
SN - 1527-5418
AD - Savin, Daniel, Department of Psychiatry, University of Colorado Health Sciences Center, University North Pavilion, Box A011-15, 4455 East 12th Avenue, Denver, CO, US, 80220
N1 - Accession Number: 2006-04072-014. PMID: 16601654 Other Journal Title: Journal of the American Academy of Child Psychiatry. Partial author list: First Author & Affiliation: Savin, Daniel; Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, US. Other Publishers: Elsevier Science. Release Date: 20060424. Correction Date: 20110207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Manson, Spero. Major Descriptor: American Indians; Mental Health Services; Psychiatry; Telemedicine. Minor Descriptor: Technology. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2006.
AB - The University of Colorado School of Medicine's Center for Native American TeleHealth and TeleEducation (CNATT) and the IHS's Rapid City Hospital began the twice-monthly Child and Adolescent Telepsychiatry Service (CATS). This is the first example to date of telepsychiatry being used to treat American Indian children. Participating providers in Rapid City include two general psychiatrists, one psychologist, and one nurse practitioner. Clinics take place on a twice-monthly basis, lasting approximately 2 hours. About 80 minutes are spent on each new evaluation with both the child and caregiver present. Our fears regarding negative effects on treatment that mistrust of government initiatives and technology in our clinic population were exaggerated. On the contrary, we found our patients and families were quite receptive to the CATS service. Telepsychiatry allows access to child and adolescent psychiatric services to American Indian children for whom such services would not otherwise be available. The necessary technology is readily available and easy to use. The high patient and provider satisfaction we observed supports the use of telepsychiatry. The cost is similar to and considerably more convenient than the cost of providing face-to-face psychiatric services to this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indian children
KW - telepsychiatry
KW - psychiatric services
KW - technology
KW - 2006
KW - American Indians
KW - Mental Health Services
KW - Psychiatry
KW - Telemedicine
KW - Technology
KW - 2006
U1 - Sponsor: National Center for Minority Health and Health Disparities. Grant: MD000507. Recipients: Manson, Spero (Prin Inv)
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: HS10854. Recipients: Manson, Spero (Prin Inv)
DO - 10.1097/01.chi.0000198594.68820.59
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04072-014&site=ehost-live&scope=site
UR - daniel.savin@uchsc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05336-003
AN - 2006-05336-003
AU - Knowlton, Amy
AU - Arnsten, Julia
AU - Eldred, Lois
AU - Wilkinson, James
AU - Gourevitch, Marc
AU - Shade, Starley
AU - Dowling, Krista
AU - Purcell, David
T1 - Individual, Interpersonal, and Structural Correlates of Effective HAART Use Among Urban Active Injection Drug Users.
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2006/04//
VL - 41
IS - 4
SP - 486
EP - 492
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Knowlton, Amy, Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, US, 21205
N1 - Accession Number: 2006-05336-003. Partial author list: First Author & Affiliation: Knowlton, Amy; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US. Institutional Authors: INSPIRE Team. Release Date: 20061023. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; Drug Abuse; Drug Therapy; HIV; Intravenous Drug Usage. Minor Descriptor: Housing; Social Support; Therapeutic Processes; Urban Environments. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2006.
AB - Among individuals receiving highly active antiretroviral therapy (HAART), injection drug users (IDUs) are less likely to achieve HIV suppression. The present study examined individuallevel, interpersonal, and structural factors associated with achieving undetectable plasma viral load (UVL) among US IDUs receiving recommended HAART. Data were from baseline assessments of the INSPIRE (Interventions for Seropositive Injectors-Research and Evaluation) study, a 4-site, secondary HIV prevention intervention for heterosexually active IDUs. Of 1113 study participants at baseline, 42% (n = 466) were currently taking recommended HAART (34% were female, 69% non-Hispanic black, 26% recently homeless; median age was 43 years), of whom 132 (28%) had a UVL. Logistic regression revealed that among those on recommended HAART, adjusted odds of UVL were at least 3 times higher among those with high social support, stable housing, and CD4 > 200; UVL was approximately 60% higher among those reporting better patient-provider communication. Outpatient drug treatment and non-Hispanic black race and an interaction between current drug use and social support were marginally negatively significant. Among those with high perceived support, noncurrent drug users compared with current drug users had a greater likelihood of UVL; current drug use was not associated with UVL among those with low support. Depressive symptoms (Brief Symptom Inventory) were not significant. Results suggest the major role of social support in facilitating effective HAART use in this population and suggest that active drug use may interfere with HAART use by adversely affecting social support. Interventions promoting social support functioning, patient-provider communication, stable housing, and drug abuse treatment may facilitate effective HAART use in this vulnerable population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - highly active antiretroviral therapy
KW - urban active injection drug users
KW - HIV suppression
KW - social support
KW - patient provider communication
KW - housing
KW - 2006
KW - AIDS Prevention
KW - Drug Abuse
KW - Drug Therapy
KW - HIV
KW - Intravenous Drug Usage
KW - Housing
KW - Social Support
KW - Therapeutic Processes
KW - Urban Environments
KW - 2006
U1 - Sponsor: Centers for Disease Control and Prevention, Health Resources and Services Administration. Grant: CDC/HRSA U50CCU317999. Recipients: No recipient indicated
DO - 10.1097/01.qai.0000186392.26334.e3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05336-003&site=ehost-live&scope=site
UR - ORCID: 0000-0001-8125-5168
UR - ORCID: 0000-0001-6865-2126
UR -
UR - aknowlto@jhsph.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04401-013
AN - 2006-04401-013
AU - Libby, Anne M.
AU - Orton, Heather D.
AU - Barth, Richard P.
AU - Webb, Mary Bruce
AU - Burns, Barbara J.
AU - Wood, Patricia
AU - Spicer, Paul
T1 - Alcohol, Drug, and Mental Health Specialty Treatment Services and Race/ Ethnicity: A National Study of Children and Families Involved With Child Welfare.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/04//
VL - 96
IS - 4
SP - 628
EP - 631
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Libby, Anne M., University of Colorado Health Sciences Center, School of Medicine, Nighthorse Campbell Native Health Building, PO Box 6508, Campus Box F800, Aurora, CO, US, 80045
N1 - Accession Number: 2006-04401-013. PMID: 16507729 Partial author list: First Author & Affiliation: Libby, Anne M.; American Indian and Alaskan Native Programs, University of Colorado, Denver, CO, US. Release Date: 20060925. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Libby, Anne M. Major Descriptor: Alcohols; American Indians; Drugs; Mental Health Services; Latinos/Latinas. Minor Descriptor: Blacks; Caregivers; Child Welfare; Ethnic Identity; Race (Anthropological); Whites. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Apr, 2006.
AB - We used data on a national sample of children involved with child welfare systems to compare American Indian caregivers with White, Black, and Hispanic caregivers in their need for, and receipt of, specialty alcohol, drug, and mental health treatment. American Indian caregivers were significantly less likely to receive services than were Hispanic caregivers (P < .05) but not significantly less likely than were White or Black caregivers. Child placement, child age, and caregiver psychiatric comorbidity were significantly associated with service receipt. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol
KW - drugs
KW - mental health
KW - specialty treatment services
KW - race
KW - ethnicity
KW - child welfare
KW - American Indian caregivers
KW - Whites
KW - Blacks
KW - hispanic caregivers
KW - mental health treatment
KW - 2006
KW - Alcohols
KW - American Indians
KW - Drugs
KW - Mental Health Services
KW - Latinos/Latinas
KW - Blacks
KW - Caregivers
KW - Child Welfare
KW - Ethnic Identity
KW - Race (Anthropological)
KW - Whites
KW - 2006
U1 - Sponsor: William T. Grant Foundation. Grant: 2052. Other Details: Faculty Scholars Award. Recipients: Libby, Anne M. (Prin Inv)
U1 - Sponsor: Robert Wood Johnson Foundation, Substance Abuse Policy Research Program. Grant: 47400. Recipients: Spicer, Paul (Prin Inv)
U1 - Sponsor: National Institute of Mental Health, Caring for Children in Child Welfare, US. Grant: MH59672. Recipients: No recipient indicated
DO - 10.2105/AJPH.2004.059436
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04401-013&site=ehost-live&scope=site
UR - anne.libby@uchsc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04401-015
AN - 2006-04401-015
AU - Huang, Zhihuan Jennifer
AU - Yu, Stella M.
AU - Ledsky, Rebecca
T1 - Health Status and Health Service Access and Use Among Children in U.S. Immigrant Families.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/04//
VL - 96
IS - 4
SP - 634
EP - 640
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Huang, Zhihuan Jennifer, Department of International Health-NHS, Georgetown University, St. Mary's Hall 215, Box 571107, 3700 Reservoir Rd NW, Washington, DC, US, 20057
N1 - Accession Number: 2006-04401-015. PMID: 16507736 Partial author list: First Author & Affiliation: Huang, Zhihuan Jennifer; Center of Community and Health Services Research, Children's National Medical Center, Washington, DC, US. Release Date: 20060925. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Care Services; Health Care Utilization; Immigration. Minor Descriptor: Family; Health Care Delivery; Treatment Barriers. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Behavioral Problems Index. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2006.
AB - Objectives: We examined the health status and patterns of health care use of children in US immigrant families. Methods: Data from the 1999 National Survey of America's Families were used to create 3 subgroups of immigrant children: US-born children with noncitizen parents,foreign-born children who were naturalized US citizens, and foreign-born children with noncitizen parents. Chi-square and logistic regression analyses were used to examine relationships between immigrant status and health access variables. Subgroup analyses were conducted with low-income families. Results: Foreign-born noncitizen children were 4 times more likely than children from native families to lack health insurance coverage and to have not visited a mental health specialist in the preceding year. They were 40% and 80% more likely to have not visited a doctor or dentist in the previous year and twice as likely to lack a usual source of care. US-born children with noncitizen parents were also at a disadvantage in many of these aspects of care. Conclusions: We found that, overall, children from immigrant families were in worse physical health than children from non-immigrant families and used health care services at a significantly lower frequency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health status
KW - health service access
KW - immigrant families
KW - health care use
KW - health care services
KW - 2006
KW - Health
KW - Health Care Services
KW - Health Care Utilization
KW - Immigration
KW - Family
KW - Health Care Delivery
KW - Treatment Barriers
KW - 2006
DO - 10.2105/AJPH.2004.049791
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04401-015&site=ehost-live&scope=site
UR - zh34@georgetown.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04071-001
AN - 2006-04071-001
AU - Clancy, Carolyn M.
T1 - AHQRs National Healthcare Quality and Disparities Reports: Resources for health services researchers.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2006/04//
VL - 41
IS - 2
SP - xiii
EP - xix
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
N1 - Accession Number: 2006-04071-001. PMID: 16584450 Partial author list: First Author & Affiliation: Clancy, Carolyn M.; Agency for Healthcare Research and Quality, Washington, DC, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20060918. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Quality of Care. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 7. Issue Publication Date: Apr, 2006.
AB - In this commentary, first, the author discusses the contents of the Agency for Healthcare Research and Quality's National Healthcare Quality Report and National Healthcare Disparities Report. After that, the author briefly comments on some possible issues the reports raise for exploration by health services researchers. Each report focuses the attention of health services researchers on unanswered questions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care services
KW - quality
KW - disparity
KW - 2006
KW - Health Care Services
KW - Quality of Care
KW - 2006
DO - 10.1111/j.1475-6773.2006.00539.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04071-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Pfister, William R.
AU - Ghosh, Tapash K.
T1 - Orally Disintegrating Tablets, Products, Technologies, and Development Issues.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2006/04/02/Apr2006 Asian
M3 - Article
SP - 28
EP - 33
PB - Advanstar Communications Inc.
SN - 15432521
AB - The article informs that orally disintegrating tablets (ODTs) have emerged as a preferred alternative to conventional oral dosage forms such as tablets and capsules. According to recent market studies, more than half of the patient population prefers ODTs to other dosage forms due to ease of administration, ease of swallowing, pleasant taste, and the availability of several flavors. However, the application of this technology is limited by the amount of drug that can be incorporated into each unit dose. INSET: Descriptions of orally disintegrating dosage forms.
KW - ORAL medication
KW - ADMINISTRATION of drugs
KW - THERAPEUTICS
KW - TABLETS (Medicine)
KW - CAPSULES (Pharmacy)
KW - DOSAGE of drugs
N1 - Accession Number: 20920320; Pfister, William R. 1; Ghosh, Tapash K. 2; Affiliations: 1: Senior director of preclinical affairs, NexMed (USA), Inc., Robbinsville, N.J.; 2: Senior clinical pharmacology and biopharmaceutics reviewer, US Food and Drug Administration (HFD 880), 9201 Corporate Blvd., Room N224, Rockville, MD 20850.; Issue Info: Apr2006 Asian, p28; Subject Term: ORAL medication; Subject Term: ADMINISTRATION of drugs; Subject Term: THERAPEUTICS; Subject Term: TABLETS (Medicine); Subject Term: CAPSULES (Pharmacy); Subject Term: DOSAGE of drugs; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=20920320&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rowlands, J. Craig
AU - Hoadley, James E.
T1 - FDA perspectives on health claims for food labels
JO - Toxicology
JF - Toxicology
Y1 - 2006/04/03/
VL - 221
IS - 1
M3 - Article
SP - 35
EP - 43
SN - 0300483X
AB - Abstract: The U.S. Food and Drug Administration''s regulatory authority over health claims was clarified in 1990 legislation known as the Nutrition Labeling and Education Act (NLEA). This law established mandatory nutrition labeling for most foods and placed restrictions on the use of food label claims characterizing the levels or health benefits of nutrients in foods. NLEA set a high threshold for the scientific standard under which the U.S. Food and Drug Administration (FDA) may authorize health claims, this standard is known as the significant scientific agreement (SSA) standard. Subsequent legislation known as the Food and Drug Administration Modernization Act (FDAMA) provided an alternative to FDA review of the health claim where an U.S. government scientific body other than FDA concluded that there is SSA for a substance/disease relationship. Courts have since extended the scope of health claims to include qualified health claims (QHC) that are health claims not substantiated on evidence that meets the level of SSA standard, but include a qualifying statement intended to convey to the consumer the level of evidence for the claim. FDA has responded by developing an evidence-based ranking system for scientific data to determine the level of evidence substantiating a health claim. The following is an overview of FDA''s regulations and evidence-based method for evaluating health claims. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling -- Law & legislation
KW - LABELS
KW - GOVERNMENT policy
KW - CONSUMER law
KW - 1990 Nutrition Labeling Education Act ( NLEA )
KW - 1994 Dietary Supplement Health and Education Act ( DSHEA )
KW - 1998 Food and Drug Administration Modernization Act ( FDAMA )
KW - Code of Federal Regulations ( CFR )
KW - Evidence-based ranking system
KW - Health claim
KW - Nutrient content claim
KW - Nutrition Facts Panel
KW - Nutrition Labeling Education Act
KW - significant scientific agreement ( SSA )
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 19915963; Rowlands, J. Craig; Email Address: JCRowlands@Dow.com Hoadley, James E. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Source Info: Apr2006, Vol. 221 Issue 1, p35; Subject Term: FOOD labeling -- Law & legislation; Subject Term: LABELS; Subject Term: GOVERNMENT policy; Subject Term: CONSUMER law; Author-Supplied Keyword: 1990 Nutrition Labeling Education Act ( NLEA ); Author-Supplied Keyword: 1994 Dietary Supplement Health and Education Act ( DSHEA ); Author-Supplied Keyword: 1998 Food and Drug Administration Modernization Act ( FDAMA ); Author-Supplied Keyword: Code of Federal Regulations ( CFR ); Author-Supplied Keyword: Evidence-based ranking system; Author-Supplied Keyword: Health claim; Author-Supplied Keyword: Nutrient content claim; Author-Supplied Keyword: Nutrition Facts Panel; Author-Supplied Keyword: Nutrition Labeling Education Act; Author-Supplied Keyword: significant scientific agreement ( SSA ); Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2005.10.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19915963&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Ji Yeon
AU - Kim, Dai Byung
AU - Lee, Hyong Joo
T1 - Regulations on health/functional foods in Korea
JO - Toxicology
JF - Toxicology
Y1 - 2006/04/03/
VL - 221
IS - 1
M3 - Article
SP - 112
EP - 118
SN - 0300483X
AB - Abstract: The term “health/functional food” (HFF) refers to food supplements containing nutrients or other substances (in a concentrated form) that have a nutritional or physiological effect whose purpose is to supplement the normal diet. The Korean Health/Functional Food Act that came into effect in 2004 requires these products to be marketed in measured doses, such as in pills, tablets, capsules, and liquids. HFFs are of two types: generic and product-specific. There are 37 ingredients listed in the act for generic HFFs, and if an HFF contains a new active ingredient that is not included in the generic 37 products, it is considered a product-specific HFF. The standardization, safety, and efficacy of a new active ingredient are reviewed by the Korean Food and Drug Administration in order to receive approval as a product-specific HFF. Conforming with international standards and protecting public health requires constant upgrading of the Health/Functional Food Act. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRADE regulation
KW - FUNCTIONAL foods
KW - GOVERNMENT policy
KW - CONSUMER law
KW - KOREA
KW - Efficacy
KW - Health/Functional Food Act
KW - Product-specific HFF
KW - Safety
KW - Standardization
N1 - Accession Number: 19915970; Kim, Ji Yeon 1 Kim, Dai Byung 1 Lee, Hyong Joo 2; Email Address: leehyjo@snu.ac.kr; Affiliation: 1: Nutrition and Functional Food Headquarters, Korea Food and Drug Administration, Seoul 122-704, South Korea 2: Program in Food Science and Biotechnology, School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-742, South Korea; Source Info: Apr2006, Vol. 221 Issue 1, p112; Subject Term: TRADE regulation; Subject Term: FUNCTIONAL foods; Subject Term: GOVERNMENT policy; Subject Term: CONSUMER law; Subject Term: KOREA; Author-Supplied Keyword: Efficacy; Author-Supplied Keyword: Health/Functional Food Act; Author-Supplied Keyword: Product-specific HFF; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Standardization; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.tox.2006.01.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=19915970&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 108194456
T1 - Recent developments in vaccination.
AU - Roberts R
Y1 - 2006/04/03/
N1 - Accession Number: 108194456. Language: English. Entry Date: 20120427. Revision Date: 20150712. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 0410033.
KW - Immunization -- Evaluation
KW - Immunization -- Methods
KW - Drug Design
KW - Hepatitis B -- Prevention and Control
KW - Hepatitis B -- Therapy
KW - Meningococcal Infections -- Prevention and Control
KW - Substance Abusers
KW - United Kingdom
KW - World Health Organization
SP - 41
EP - 47
JO - Update
JF - Update
JA - UPDATE (0301-5718)
VL - 72
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0301-5718
AD - Head, Vaccine Preventable Disease Programme, National Public Health Service for Wales
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=108194456&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kostelansky, Michael S.
AU - Sun, Ji
AU - Lee, Sangho
AU - Kim, Jaewon
AU - Ghirlando, Rodolfo
AU - Hierro, Aitor
AU - Emr, Scott D.
AU - Hurley, James H.
T1 - Structural and Functional Organization of the ESCRT-I Trafficking Complex
JO - Cell
JF - Cell
Y1 - 2006/04/07/
VL - 125
IS - 1
M3 - Article
SP - 113
EP - 126
SN - 00928674
AB - Summary: The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 Å resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners. [Copyright &y& Elsevier]
AB - Copyright of Cell is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAVENING agents
KW - LYSOSOMES
KW - ORIGIN of life
KW - ENDOSOMES
N1 - Accession Number: 20400040; Kostelansky, Michael S. 1 Sun, Ji 2 Lee, Sangho 1 Kim, Jaewon 1 Ghirlando, Rodolfo 1 Hierro, Aitor 1 Emr, Scott D. 2 Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA 2: Department of Cellular and Molecular Medicine, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Source Info: Apr2006, Vol. 125 Issue 1, p113; Subject Term: LEAVENING agents; Subject Term: LYSOSOMES; Subject Term: ORIGIN of life; Subject Term: ENDOSOMES; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.cell.2006.01.049
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20400040&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ge, Xudong
AU - Hanson, Michael
AU - Shen, Hong
AU - Kostov, Yordan
AU - Brorson, Kurt A.
AU - Frey, Douglas D.
AU - Moreira, Antonio R.
AU - Rao, Govind
T1 - Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture
JO - Journal of Biotechnology
JF - Journal of Biotechnology
Y1 - 2006/04/10/
VL - 122
IS - 3
M3 - Article
SP - 293
EP - 306
SN - 01681656
AB - Abstract: Cell culture optimization is a labor-intensive process requiring a large number of experiments to be conducted under varying conditions. Here we describe a high-throughput bioreactor system that allows 12 mini stirred-tank bioreactors to be operated simultaneously. All bioreactors are monitored by low-cost minimally invasive optical sensors for pH and dissolved oxygen. The sensors consist of single-use patches affixed inside the bioreactors and monitored optically from the outside. Experimental results show that different sensing patches with the same composition respond consistently. The discrepancy between different pH sensors is less than 0.1 pH units over most of their responsive range. The discrepancy between different dissolved oxygen sensors is less than 10% over the whole range from 0% to 100% dissolved oxygen. The consistency of the sensing system ensures that only an initial one-time calibration is required for the sensing patches. After that, a calibration code is generated and sensing patches of the same composition can be used directly. This greatly reduces the time and cost required for monitored multi-bioreactor operations. We used SP2/0 myeloma/mouse hybridoma cell cultures to demonstrate reactor performance consistency. Transcriptional profiling, HPLC analysis, viable cell count, and viability inspection show that the presence of sensing patches and the use of optical monitoring have no apparent effect on the metabolism of the cells. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biotechnology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL culture
KW - OXYGEN
KW - BIOREACTORS
KW - HYDROGEN-ion concentration
KW - High-throughput bioreactor
KW - Mammalian cell culture
KW - Non-invasive
KW - Optical sensor
KW - Transcriptional profiling
N1 - Accession Number: 20009832; Ge, Xudong 1 Hanson, Michael 1,2 Shen, Hong 1 Kostov, Yordan 1 Brorson, Kurt A. 2 Frey, Douglas D. 1 Moreira, Antonio R. 1 Rao, Govind 1; Email Address: grao@umbc.edu; Affiliation: 1: Center for Advanced Sensor Technology, Department of Chemical and Biochemical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States 2: Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, United States; Source Info: Apr2006, Vol. 122 Issue 3, p293; Subject Term: CELL culture; Subject Term: OXYGEN; Subject Term: BIOREACTORS; Subject Term: HYDROGEN-ion concentration; Author-Supplied Keyword: High-throughput bioreactor; Author-Supplied Keyword: Mammalian cell culture; Author-Supplied Keyword: Non-invasive; Author-Supplied Keyword: Optical sensor; Author-Supplied Keyword: Transcriptional profiling; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jbiotec.2005.12.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raychaudhuri, Sumana
AU - Im, Young Jun
AU - Hurley, James H.
AU - Prinz, William A.
T1 - Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.
JO - Journal of Cell Biology
JF - Journal of Cell Biology
Y1 - 2006/04/10/
VL - 173
IS - 1
M3 - Article
SP - 107
EP - 119
SN - 00219525
AB - Sterols are moved between cellular membranes by nonvesicular pathways whose functions are poorly understood. In yeast, one such pathway transfers sterols from the plasma membrane (PM) to the endoplasmic reticulum (ER). We Show that this transport requires oxysterol-binding protein (OSBP)-related proteins (ORPs), which are a large family of conserved lipid-binding proteins. We demonstrate that a representative member of this family, Osh4p/Kes1p, specifically facilitates the nonvesicular transfer of cholesterol and ergosterol between membranes in vitro. In addition, Osh4p transfers sterols more rapidly between membranes containing phosphoinositides (PIPs), suggesting that PIPs regulate sterol transport by ORPs. We confirmed this by showing that PM to ER sterol transport slows dramatically in mutants with conditional defects in PIP biosynthesis. Our findings argue that ORPs move sterols among cellular compartments and that sterol transport and intracellular distribution are regulated by PIPs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Biology is the property of Rockefeller University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL membranes
KW - BIOLOGICAL membranes
KW - STEROLS
KW - PHOSPHOINOSITIDES
KW - ENDOPLASMIC reticulum
N1 - Accession Number: 20781761; Raychaudhuri, Sumana 1 Im, Young Jun 2,3 Hurley, James H. 2 Prinz, William A. 1; Email Address: wprinz@helix.nih.gov; Affiliation: 1: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 2: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892 3: Dept. of Life Science, Gwangju Institute of Science and Technology, Gwangju City, 500-712, South Korea; Source Info: 4/10/2006, Vol. 173 Issue 1, p107; Subject Term: CELL membranes; Subject Term: BIOLOGICAL membranes; Subject Term: STEROLS; Subject Term: PHOSPHOINOSITIDES; Subject Term: ENDOPLASMIC reticulum; Number of Pages: 13p; Document Type: Article; Full Text Word Count: 9964
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Kyu Bong
AU - Bartlett, Michael G.
AU - Anand, Sathanandam S.
AU - Bruckner, James V.
AU - Kim, Hyo Jung
T1 - Rapid determination of the synthetic pyrethroid insecticide, deltamethrin, in rat plasma and tissues by HPLC
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/04/13/
VL - 834
IS - 1/2
M3 - Article
SP - 141
EP - 148
SN - 15700232
AB - Abstract: Deltamethrin (DLM), [(S)-α-cyano-d-phenoxybenzyl-(1R,3R)-e-(2,2 dibromovinyl)-2,2-dimethylcyclo-propane-1-carboxylate], is a pyrethroid insecticide widely used in agriculture and households. There are several methods for analysis of DLM in biological fluids and tissues, but these methods are time consuming. They generally involve the extraction of DLM with lipid-soluble solvents such as n-pentane, n-hexane, diethylether or acetone, and subsequent evaporation of the solvent. A more rapid and sensitive high-performance liquid chromatography (HPLC) method to analyze DLM in plasma and tissues (liver, kidney, and brain) was developed and validated according to U.S. Food and Drug Administration (U.S. FDA) and International Conference on Harmonization (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines. The limit of detection (S/N of 3/1) for DLM was 0.01μg/ml for plasma, liver, kidney and brain. The method performances were shown to be selective for DLM and linear over the concentration range 0.01–20.0μg/ml. For five replications of samples at 0.05, 0.1, 0.2, 1.5 and 4.0μg/ml, intraday precision and accuracy values were in the range of 0.7–13.1% relative standard deviation (%R.S.D.) and 1.8–14.1%Error, respectively. Interday (n =15) precision and accuracy values at 0.05, 0.1, 0.2, 1.5, and 4.0μg/ml were in the range of 3.2–15.2% (%R.S.D.) and 3.7–14.8%Error, respectively. The absolute recoveries of DLM ranged from 93 to 103% for plasma, 95 to 114% for liver, 97 to 108% for kidney, and 95 to 108% for brain. This method can be quite useful for DLM pharmacokinetic and tissue distribution studies, for which multiple plasma and tissue samples have to be analyzed quickly with high reproducibility. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PYRETHROIDS
KW - INSECTICIDES
KW - EXTRACTION techniques
KW - SOLVENTS
KW - TISSUES
KW - Deltamethrin
KW - HPLC
KW - Plasma
KW - Pyrethroid insecticide
KW - Tissues
N1 - Accession Number: 20401954; Kim, Kyu Bong 1,2 Bartlett, Michael G. 1 Anand, Sathanandam S. 1 Bruckner, James V. 1; Email Address: bruckner@rx.uga.edu Kim, Hyo Jung 1; Affiliation: 1: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602, USA 2: Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea; Source Info: Apr2006, Vol. 834 Issue 1/2, p141; Subject Term: PYRETHROIDS; Subject Term: INSECTICIDES; Subject Term: EXTRACTION techniques; Subject Term: SOLVENTS; Subject Term: TISSUES; Author-Supplied Keyword: Deltamethrin; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Plasma; Author-Supplied Keyword: Pyrethroid insecticide; Author-Supplied Keyword: Tissues; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.02.039
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Rasooly, Avraham
T1 - Moving biosensors to point-of-care cancer diagnostics
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2006/04/15/
VL - 21
IS - 10
M3 - Editorial
SP - 1847
EP - 1850
SN - 09565663
KW - Biosensors
KW - Cancer diagnostics
KW - Lab-on-a-chip
KW - Ligands
KW - Microfluidics
KW - Molecular signatures
KW - Point-of-care testing
N1 - Accession Number: 20254360; Rasooly, Avraham 1,2; Email Address: rasoolya@mail.nih.gov; Affiliation: 1: Cancer Diagnosis Program (CDP) of the National Cancer Institute, MD, USA 2: Division of Biological Sciences, Office of Science and Engineering Laboratories, FDA Center for Devices and Radiological Health, MD, USA; Source Info: Apr2006, Vol. 21 Issue 10, p1847; Author-Supplied Keyword: Biosensors; Author-Supplied Keyword: Cancer diagnostics; Author-Supplied Keyword: Lab-on-a-chip; Author-Supplied Keyword: Ligands; Author-Supplied Keyword: Microfluidics; Author-Supplied Keyword: Molecular signatures; Author-Supplied Keyword: Point-of-care testing; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1016/j.bios.2006.02.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rasooly, Avraham
AU - Jacobson, James
T1 - Development of biosensors for cancer clinical testing
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2006/04/15/
VL - 21
IS - 10
M3 - Article
SP - 1851
EP - 1858
SN - 09565663
AB - Abstract: Biosensors are devices that combine a biochemical recognition/binding element (ligand) with a signal conversion unit (transducer). Biosensors are already used for several clinical applications, for example for electrochemical measurement of blood glucose concentrations. Application of biosensors in cancer clinical testing has several potential advantages over other clinical analysis methods including increased assay speed and flexibility, capability for multi-target analyses, automation, reduced costs of diagnostic testing and a potential to bring molecular diagnostic assays to community health care systems and to underserved populations. They have the potential for facilitating Point of Care Testing (POCT), where state-of-the-art molecular analysis is carried out without requiring a state-of-the-art laboratory. However, not many biosensors have been developed for cancer-related testing. One major challenge in harnessing the potential of biosensors is that cancer is a very complex set of diseases. Tumors vary widely in etiology and pathogenesis. Oncologists rely heavily on histological characterization of tumors and a few biomarkers that have demonstrated clinical utility to aid in patient management decisions. New genomic and proteomic molecular tools are being used to profile tumors and produce “molecular signatures.” These signatures include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modifications of proteins. These molecular signatures provide new opportunities for utilizing biosensors. Biosensors have enormous potential to deliver the promise of new molecular diagnostic strategies to patients. This article describes some of the basic elements of cancer biology and cancer biomarkers relevant for the development of biosensors for cancer clinical testing, along with the challenges in using this approach. [Copyright &y& Elsevier]
AB - Copyright of Biosensors & Bioelectronics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - CANCER treatment
KW - CANCER -- Diagnosis
KW - POINT-of-care testing
KW - Biosensors
KW - Cancer diagnostics
KW - Ligands
KW - Molecular signatures
KW - Point of Care Testing
N1 - Accession Number: 20254361; Rasooly, Avraham 1,2; Email Address: rasoolya@mail.nih.gov Jacobson, James 1; Affiliation: 1: Cancer Diagnosis Program (CDP) of the National Cancer Institute, United States 2: Division of Biological Sciences, Office of Science and Engineering Laboratories, FDA Center for Devices and Radiological Health, United States; Source Info: Apr2006, Vol. 21 Issue 10, p1851; Subject Term: BIOSENSORS; Subject Term: CANCER treatment; Subject Term: CANCER -- Diagnosis; Subject Term: POINT-of-care testing; Author-Supplied Keyword: Biosensors; Author-Supplied Keyword: Cancer diagnostics; Author-Supplied Keyword: Ligands; Author-Supplied Keyword: Molecular signatures; Author-Supplied Keyword: Point of Care Testing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.bios.2006.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soper, Steven A.
AU - Brown, Kathlynn
AU - Ellington, Andrew
AU - Frazier, Bruno
AU - Garcia-Manero, Guillermo
AU - Gau, Vincent
AU - Gutman, Steven I.
AU - Hayes, Daniel F.
AU - Korte, Brenda
AU - Landers, James L.
AU - Larson, Dale
AU - Ligler, Frances
AU - Majumdar, Arun
AU - Mascini, Marco
AU - Nolte, David
AU - Rosenzweig, Zeev
AU - Wang, Joseph
AU - Wilson, David
T1 - Point-of-care biosensor systems for cancer diagnostics/prognostics
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2006/04/15/
VL - 21
IS - 10
M3 - Article
SP - 1932
EP - 1942
SN - 09565663
AB - Abstract: With the growing number of fatalities resulting from the 100 or so cancer-related diseases, new enabling tools are required to provide extensive molecular profiles of patients to guide the clinician in making viable diagnosis and prognosis. Unfortunately with cancer-related diseases, there is not one molecular marker that can provide sufficient information to assist the clinician in making effective prognoses or even diagnoses. Indeed, large panels of markers must typically be evaluated that cut across several different classes (mutations in certain gene fragments—DNA; over/under-expression of gene activity as monitored by messenger RNAs; the amount of proteins present in serum or circulating tumor cells). The classical biosensor format (dipstick approach for monitoring the presence of a single element) is viewed as a valuable tool in many bioassays, but possesses numerous limitations in cancer due primarily to the single element nature of these sensing platforms. As such, if biosensors are to become valuable tools in the arsenal of the clinician to manage cancer patients, new formats are required. This review seeks to provide an overview of the current thinking on molecular profiling for diagnosis and prognosis of cancers and also, provide insight into the current state-of-the-art in the biosensor field and new strategies that must be considered to bring this important technology into the cancer field. [Copyright &y& Elsevier]
AB - Copyright of Biosensors & Bioelectronics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POINT-of-care testing
KW - BIOSENSORS
KW - CANCER -- Diagnosis
KW - CANCER patients
KW - Biosensors
KW - Cancer
KW - Point-of-care
N1 - Accession Number: 20254372; Soper, Steven A. 1; Email Address: chsope@lsu.edu Brown, Kathlynn 2 Ellington, Andrew 3 Frazier, Bruno 4 Garcia-Manero, Guillermo 5 Gau, Vincent 6 Gutman, Steven I. 7 Hayes, Daniel F. 8 Korte, Brenda 9 Landers, James L. 10 Larson, Dale 11 Ligler, Frances 12 Majumdar, Arun 13 Mascini, Marco 14 Nolte, David 15 Rosenzweig, Zeev 16 Wang, Joseph 17 Wilson, David 18; Affiliation: 1: Louisiana State University, Baton Rouge, LA 70803, United States 2: University of Texas Southwestern Medical Center, TX, United States 3: University of Texas, Austin, TX, United States 4: Georgia Tech University, CA, United States 5: University of Texas, M.D. Anderson Cancer Center, TX, United States 6: GeneFluidics, CA, United States 7: U.S. Food and Drug Administration, United States 8: University of Michigan, MI, United States 9: National Institutes of Health, United States 10: University of Virginia, VA, United States 11: Harvard Medical School, MA, United States 12: U.S. Naval Research Laboratory, United States 13: University of California, Berkeley, CA, United States 14: University of Firenze, Firenze, Italy 15: Purdue University, IN, United States 16: University of New Orleans, LA, United States 17: Arizona State University, AZ, United States 18: University of Pennsylvania, School of Medicine, PA, United States; Source Info: Apr2006, Vol. 21 Issue 10, p1932; Subject Term: POINT-of-care testing; Subject Term: BIOSENSORS; Subject Term: CANCER -- Diagnosis; Subject Term: CANCER patients; Author-Supplied Keyword: Biosensors; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Point-of-care; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.bios.2006.01.006
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Atkins, David
T1 - Study ignores economic benefits.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2006/04/15/
VL - 332
IS - 7546
M3 - Letter
SP - 916
EP - 916
SN - 09598146
AB - A letter to the editor in response to the article "Scientists find new disease: motivational deficiency disorder," in the April 1, 2006 issue is presented.
KW - LETTERS to the editor
KW - NOSOLOGY
N1 - Accession Number: 20564748; Atkins, David 1; Email Address: david.atkins@comcast.net; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 4/15/2006, Vol. 332 Issue 7546, p916; Subject Term: LETTERS to the editor; Subject Term: NOSOLOGY; Number of Pages: 1/4p; Illustrations: 1 Black and White Photograph; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guerry, Patricia
AU - Ewing, Cheryl P.
AU - Schirm, Michael
AU - Lorenzo, Maria
AU - Kelly, John
AU - Pattarini, Dawn
AU - Majam, Gary
AU - Thibault, Pierre
AU - Logan, Susan
T1 - Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2006/04/15/
VL - 60
IS - 2
M3 - Article
SP - 299
EP - 311
PB - Wiley-Blackwell
SN - 0950382X
AB - Analysis of the complete flagellin glycosylation locus of Campylobacter jejuni strain 81–176 revealed a less complex genomic organization than the corresponding region in the genome strain, C. jejuni NCTC 11168. Twenty-four of the 45 genes found between Cj1293 and Cj1337 in NCTC 11168 are missing in 81–176. Mutation of six new genes, in addition to three previously reported, resulted in a non-motile phenotype, consistent with a role in synthesis of pseudaminic acid (PseAc) or transfer of PseAc to flagellin. Mutation of Cj1316c or pseA had been shown to result in loss of the acetamidino form of pseudaminic acid (PseAm). Mutation of a second gene also resulted in loss of PseAm, as well as a minor modification that appears to be PseAm extended with N-acetyl-glutamic acid. Previously described mutants in C. jejuni 81–176 and Campylobacter coli VC167 that produced flagella lacking PseAm or PseAc failed to autoagglutinate. This suggests that interactions between modifications on adjacent flagella filaments are required for autoagglutination. Mutants (81–176) defective in autoagglutination showed a modest reduction in adherence and invasion of INT407 cells. However, there was a qualitative difference in binding patterns to INT407 cells using GFP-labelled 81–176 and mutants lacking PseAm. A mutant lacking PseAm was attenuated in the ferret diarrhoeal disease model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER jejuni
KW - FLAGELLA (Microbiology)
KW - GLYCOSYLATION
KW - AGGLUTINATION
KW - VIRULENCE (Microbiology)
KW - MOTILITY of microorganisms
KW - PATHOGENIC microorganisms
N1 - Accession Number: 20274018; Guerry, Patricia 1; Email Address: guerryp@nmrc.navy.mil Ewing, Cheryl P. 1 Schirm, Michael 2 Lorenzo, Maria 3 Kelly, John 4 Pattarini, Dawn 1 Majam, Gary 1 Thibault, Pierre 2 Logan, Susan 4; Affiliation: 1: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD, USA 2: Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada 3: Food and Drug Administration MOD1, Beltsville, MD, USA 4: National Research Council of Canada, Ottawa, ON, Canada; Source Info: Apr2006, Vol. 60 Issue 2, p299; Subject Term: CAMPYLOBACTER jejuni; Subject Term: FLAGELLA (Microbiology); Subject Term: GLYCOSYLATION; Subject Term: AGGLUTINATION; Subject Term: VIRULENCE (Microbiology); Subject Term: MOTILITY of microorganisms; Subject Term: PATHOGENIC microorganisms; Number of Pages: 13p; Illustrations: 1 Color Photograph, 2 Diagrams, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2958.2006.05100.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore, Martha M.
AU - Chen, Tao
T1 - Mutagenicity of bromate: Implications for cancer risk assessment
JO - Toxicology
JF - Toxicology
Y1 - 2006/04/17/
VL - 221
IS - 2/3
M3 - Article
SP - 190
EP - 196
SN - 0300483X
AB - Abstract: Bromate (BrO3−) is a rodent carcinogen that is formed as a drinking water ozone disinfection by-product and also used in some food and consumer products. Therefore, bromate is subject to assessment for its risk to humans. Because the selection of an appropriate model for conducting quantitative cancer risk assessment is based upon an understanding of the chemical''s mode-of-action, it is necessary to determine whether the chemical is a mutagenic carcinogen. We present a review of the available information concerning the weight-of-the-evidence that bromate is a mutagenic carcinogen. The evidence indicates that bromate is mutagenic and that this activity is mediated by the formation of oxidative damage to the DNA, thus resulting in chromosomal damage. Not only does bromate induce genetic damage in vitro, it is also demonstrated to induce mutations in the kidney of exposed rats. This is significant because the rat kidney is one of the target tissues for tumor induction. While it is clear that bromate can cause damage in the target tissue, it is not clear whether bromate is a mutagenic carcinogen, that is, whether the observed tumors result from a mutagenic mode-of-action. Further research is needed to clarify bromate''s mode-of-action. However, in the absence of additional information, it is reasonable, based on an extensive database, to assume that bromate induces tumors via oxidative damage that causes chromosomal breakage. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENICITY testing
KW - BROMATE
KW - DNA adducts
KW - CARCINOGENESIS
KW - Genotoxicity
KW - Mutagenicity
KW - Potassium bromate
KW - Risk assessment
KW - Sodium bromate
N1 - Accession Number: 20526938; Moore, Martha M.; Email Address: mmmoore@nctr.fda.gov Chen, Tao 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, HFT-120, NCTR, 3900 NCTR Rd., Jefferson, AR 72079, USA; Source Info: Apr2006, Vol. 221 Issue 2/3, p190; Subject Term: MUTAGENICITY testing; Subject Term: BROMATE; Subject Term: DNA adducts; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Potassium bromate; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Sodium bromate; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.tox.2005.12.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20526938&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Barton, Mary B.
T1 - Exploring and Crossing the Disparity Divide in Cancer Mortality.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2006/04/18/
VL - 144
IS - 8
M3 - Editorial
SP - 614
EP - 616
SN - 00034819
AB - The article presents information on the disparities in access to health care in the U.S. by referring to data related to cancer mortality. According to data, Hispanic women have higher rates of late-stage cervical cancer diagnoses than do non-Hispanic white women and the excess burden of death from breast cancer among African-American women occurs despite a lower incidence of breast cancer than that for white women. To improve the situation, more frequent screening should be done, especially among women who have been never screened or those who have been infrequently screened.
KW - CANCER -- Mortality
KW - HISPANIC American women
KW - AFRICAN American women
KW - CANCER -- Diagnosis
KW - MEDICAL care -- United States
KW - MEDICAL screening
KW - HEALTH services accessibility
KW - UNITED States
N1 - Accession Number: 20517000; Barton, Mary B. 1; Email Address: mbarton@ahrq.gov; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, MD 20850.; Source Info: 4/18/2006, Vol. 144 Issue 8, p614; Subject Term: CANCER -- Mortality; Subject Term: HISPANIC American women; Subject Term: AFRICAN American women; Subject Term: CANCER -- Diagnosis; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL screening; Subject Term: HEALTH services accessibility; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106145118
T1 - Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations.
AU - Aletras AH
AU - Tilak GS
AU - Natanzon A
AU - Hsu LY
AU - Gonzalez FM
AU - Hoyt RF Jr
AU - Arai AE
Y1 - 2006/04/18/2006 Apr 18
N1 - Accession Number: 106145118. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0147763.
KW - Echocardiography -- Methods
KW - Magnetic Resonance Imaging
KW - Myocardial Infarction -- Therapy
KW - Myocardial Reperfusion
KW - Dogs
KW - Heart Failure -- Diagnosis
KW - Heart Failure -- Risk Factors
KW - Heart -- Physiopathology
KW - Latex
KW - Myocardial Infarction -- Diagnosis
KW - Myocardial Infarction -- Physiopathology
KW - Myocardial Infarction -- Risk Factors
KW - Myocardium -- Pathology
KW - Recovery
KW - Reproducibility of Results
KW - Time Factors
KW - Animal Studies
SP - 1865
EP - 1870
JO - Circulation
JF - Circulation
JA - CIRCULATION
VL - 113
IS - 15
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: The aim of this study was to determine whether edema imaging by T2-weighted cardiac magnetic resonance (CMR) imaging could retrospectively delineate the area at risk in reperfused myocardial infarction. We hypothesized that the size of the area at risk during a transient occlusion would be similar to the T2-weighted hyperintense region observed 2 days later, that the T2-weighted hyperintense myocardium would show partial functional recovery after 2 months, and that the T2 abnormality would resolve over 2 months. METHODS AND RESULTS: Seventeen dogs underwent a 90-minute coronary artery occlusion, followed by reperfusion. The area at risk, as measured with microspheres (9 animals), was comparable to the size of the hyperintense zone on T2-weighted images 2 days later (43.4+/-3.3% versus 43.0+/-3.4% of the left ventricle; P=NS), and the 2 measures correlated (R=0.84). The infarcted zone was significantly smaller (23.1+/-3.7; both P<0.001). To test whether the hyperintense myocardium would exhibit partial functional recovery over time, 8 animals were imaged on day 2 and 2 months later. Systolic strain was mapped with displacement encoding with stimulated echoes. Edema, as detected by a hyperintense zone on T2-weighted images, resolved, and regional radial systolic strain partially improved from 4.9+/-0.7 to 13.1+/-1.5 (P=0.001) over 2 months. CONCLUSIONS: These findings are consistent with the premise that the T2 abnormality depicts the area at risk, a zone of reversibly and irreversibly injured myocardium associated with reperfused subendocardial infarctions. The persistence of postischemic edema allows T2-weighted CMR to delineate the area at risk 2 days after reperfused myocardial infarction.
SN - 0009-7322
AD - National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-1061, USA.
U2 - PMID: 16606793.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Virmani, Renu
AU - Burke, Allen P.
AU - Farb, Andrew
AU - Kolodgie, Frank D.
T1 - Pathology of the Vulnerable Plaque
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2006/04/19/Apr2006 Supplement
VL - 47
M3 - Article
SP - C13
EP - C18
SN - 07351097
AB - The majority of patients with acute coronary syndromes (ACS) present with unstable angina, acute myocardial infarction, and sudden coronary death. The most common cause of coronary thrombosis is plaque rupture followed by plaque erosion, whereas calcified nodule is infrequent. If advances in coronary disease are to occur, it is important to recognize the precursor lesion of ACS. Of the three types of coronary thrombosis, a precursor lesion for acute rupture has been postulated. The non-thrombosed lesion that most resembles the acute plaque rupture is the thin cap fibroatheroma (TCFA), which is characterized by a necrotic core with an overlying fibrous cap measuring <65 μm, containing rare smooth muscle cells but numerous macrophages. Thin cap fibroatheromas are most frequently observed in patients dying with acute myocardial infarction and least common in plaque erosion. They are most frequently observed in proximal coronary arteries, followed by mid and distal major coronary arteries. Vessels demonstrating TCFA do not usually show severe narrowing but show positive remodeling. In TCFAs the necrotic core length is approximately 2 to 17 mm (mean 8 mm) and the underlying cross-sectional area narrowing in over 75% of cases is <75% (diameter stenosis <50%). The area of the necrotic core in at least 75% of cases is ≤3 mm2. These lesions have lesser degree of calcification than plaque ruptures. Thin cap fibroatheromas are common in patients with high total cholesterol (TC) and high TC/high-density lipoprotein cholesterol ratio, in women >50 years, and in those patients with elevated high levels of high sensitivity C-reactive protein. It has only recently been recognized that their identification in living patients might help reduce the incidence of sudden coronary death. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORONARY heart disease
KW - PATIENTS
KW - MYOCARDIAL infarction
KW - HEART diseases
KW - CARDIOVASCULAR diseases
KW - THROMBOSIS
KW - CORONARY arteries
KW - SMOOTH muscle
KW - C-reactive protein
KW - MACROPHAGES
KW - CHOLESTEROL
KW - acute coronary syndromes ( ACS )
KW - C-reactive protein ( CRP )
KW - high-density lipoprotein ( HDL )
KW - myeloperoxidase ( MPO )
KW - thin cap fibroatheroma ( TCFA )
KW - total cholesterol ( TC )
N1 - Accession Number: 20566258; Virmani, Renu 1; Email Address: rvirmani@cvpath.org Burke, Allen P. 1 Farb, Andrew 2 Kolodgie, Frank D. 1; Affiliation: 1: CVPath, International Registry of Pathology, Gaithersburg, Maryland 2: U.S. Food and Drug Administration, CDRH-ODE-DCD-ICDB, Rockville, Maryland; Source Info: Apr2006 Supplement, Vol. 47, pC13; Subject Term: CORONARY heart disease; Subject Term: PATIENTS; Subject Term: MYOCARDIAL infarction; Subject Term: HEART diseases; Subject Term: CARDIOVASCULAR diseases; Subject Term: THROMBOSIS; Subject Term: CORONARY arteries; Subject Term: SMOOTH muscle; Subject Term: C-reactive protein; Subject Term: MACROPHAGES; Subject Term: CHOLESTEROL; Author-Supplied Keyword: acute coronary syndromes ( ACS ); Author-Supplied Keyword: C-reactive protein ( CRP ); Author-Supplied Keyword: high-density lipoprotein ( HDL ); Author-Supplied Keyword: myeloperoxidase ( MPO ); Author-Supplied Keyword: thin cap fibroatheroma ( TCFA ); Author-Supplied Keyword: total cholesterol ( TC ); Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jacc.2005.10.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goter-Robinson, Carol
AU - Derrick, Steven C.
AU - Yang, Amy Li
AU - Jeon, Bo Young
AU - Morris, Sheldon L.
T1 - Protection against an aerogenic Mycobacterium tuberculosis infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses
JO - Vaccine
JF - Vaccine
Y1 - 2006/04/24/
VL - 24
IS - 17
M3 - Article
SP - 3522
EP - 3529
SN - 0264410X
AB - Abstract: Although vaccination against tuberculosis (TB) was initiated more than 80 years ago, the correlates of protective immunity against infection by Mycobacterium tuberculosis have still not been well defined. To investigate the vaccine-induced immune responses against TB, we evaluated the early pulmonary cytokine responses elicited by a low dose M. tuberculosis aerogenic challenge in mice that had been immunized with either BCG or a TB DNA vaccine cocktail, two vaccine preparations that induce long-term protection in the mouse model of pulmonary TB. Using three different assays, we showed that specific cytokine responses were elevated in the lungs of vaccinated mice (relative to naïve controls) during the second week post-challenge. By measuring cytokine levels in the bronchoalveolar lavage fluid (BAL) and cytokine mRNA concentrations in pulmonary cells, the levels of IFN-γ, IL-12, and RANTES were shown to be elevated from days 7–14 post-challenge in the lungs. By intracellular cytokine staining (ICS), increased numbers of lung CD4 and CD8 cells expressing IFN-γ were also seen at days 10 and 14 after the infection. Moreover, increased post-challenge IFN-γ levels were detected using the ICS and cytokine mRNA assays in aging BCG-immunized mice that had been effectively boosted with a TB DNA vaccine. Taken together, these data suggest that the post-infection induction of early type 1 cytokine responses correlate with the induction of long-term protective immunity in vaccinated mice. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cellular immunity
KW - Tuberculosis
KW - Lung diseases
KW - Mycobacterial diseases
KW - BCG
KW - DNA Vaccines
KW - Interferon-γ
N1 - Accession Number: 20526900; Goter-Robinson, Carol 1; Derrick, Steven C.; Email Address: derrick@cber.fda.gov; Yang, Amy Li 1; Jeon, Bo Young 1; Morris, Sheldon L. 1; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Building 29/Room 509, CBER/FDA, 29 Lincoln Dr., Bethesda, MD 20892, USA; Issue Info: Apr2006, Vol. 24 Issue 17, p3522; Thesaurus Term: Cellular immunity; Thesaurus Term: Tuberculosis; Subject Term: Lung diseases; Subject Term: Mycobacterial diseases; Author-Supplied Keyword: BCG; Author-Supplied Keyword: DNA Vaccines; Author-Supplied Keyword: Interferon-γ; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.02.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bryant-Genevier, Marthe
AU - O’Connell, Kathryn
AU - Ball, Robert
AU - Braun, M. Miles
AU - McMahon, Ann
T1 - Passive surveillance for generalized vaccinia in the United States using the Vaccine Adverse Event Reporting System (VAERS)
JO - Vaccine
JF - Vaccine
Y1 - 2006/04/24/
VL - 24
IS - 17
M3 - Article
SP - 3632
EP - 3635
SN - 0264410X
AB - Abstract: Background: Generalized vaccinia (GV) is an adverse event specifically associated with smallpox vaccination, but shares clinical features with many common non-vaccine related rashes. We assessed the utility of passive reporting for GV surveillance by reviewing all Vaccine Adverse Event Reporting System (VAERS) reports of any post-smallpox vaccination rash in civilians and military personnel. Methods: We reviewed all reports submitted to VAERS between 12/12/2002 and 3/1 2004 for post-smallpox vaccine (SPV) rashes concerning civilians and military personnel. We evaluated the information contained in the reports independent of VAERS adverse event coding (GV or not GV). We classified the rash reports based on the recently published GV case definition from the Centers for Disease Control and Prevention. Results: Of the 936 rash reports after SPV, 92 were coded as GV. We classified 12 of the 92 as probable GV, and 1 as confirmed GV (14% probable or confirmed). Among the 844 reports not coded as GV, we classified 32 as either probable or confirmed GV (4%). Probable or confirmed reports that were coded as GV were similar to probable or confirmed reports not coded as GV with respect to demographic characteristics of the report subjects, and the location and phenotype (e.g., pustular, vesicular, etc.) of the rashes. Conclusions: A prospective study that applies well-defined clinical, histopathological, and laboratory criteria to smallpox-vaccinated patients with rashes would be necessary to distinguish GV from common alternative diagnoses with which it is easily confused. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Smallpox
KW - Smallpox
KW - Poxvirus diseases
KW - Generalized vaccinia
KW - Passive surveillance
KW - Smallpox vaccination
N1 - Accession Number: 20526913; Bryant-Genevier, Marthe 1; Email Address: bryant-genevier@cber.fda.gov; O’Connell, Kathryn 2; Ball, Robert 1; Braun, M. Miles 1; McMahon, Ann 1; Affiliations: 1: CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA; 2: CBER/OBE/DE/Therapeutics and Blood Safety Branch, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA; Issue Info: Apr2006, Vol. 24 Issue 17, p3632; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Thesaurus Term: Smallpox; Subject Term: Smallpox; Subject Term: Poxvirus diseases; Author-Supplied Keyword: Generalized vaccinia; Author-Supplied Keyword: Passive surveillance; Author-Supplied Keyword: Smallpox vaccination; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.01.052
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tournas, V.H.
AU - Katsoudas, Eugenia
AU - Miracco, E.J.
T1 - Moulds, yeasts and aerobic plate counts in ginseng supplements
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006/04/25/
VL - 108
IS - 2
M3 - Article
SP - 178
EP - 181
SN - 01681605
AB - Abstract: Forty six ginseng supplement samples including Siberian ginseng root, Chinese ginseng herb and root, and American ginseng root and extract were purchased from retail in the Washington, DC area and from Penn Herb Co. (Philadelphia, PA) and tested for mould and yeast (MY) contamination and the presence of aerobic mesophilic bacteria (APC). Results indicated that 100% of the Siberian ginseng samples were contaminated with fungi and bacteria. MY counts ranged from 8.0×102 to 1.4×103 cfu/g whereas the APCs were between 2.3×104 and 1.0×106 cfu/g. Most common fungi encountered in this commodity were Penicillium spp., Eurotium rubrum, E. chevalieri and Rhizopus spp. Seventy-eight percent of the Chinese ginseng herb samples were contaminated with fungi and 89% with bacteria at levels ranging between <100 and 6.0×104 and <100 and 1.2×106 cfu/g, respectively. Moulds commonly isolated were Alternaria alternata, Aspergillus niger, Aspergillus spp., Cladosporium spp., E. chevalieri, Penicillium spp. and Rhizopus spp. Fifty six percent of the Chinese ginseng root samples tested contained fungi (A. niger, Rhizopus spp. and yeasts), and 100% contained bacteria. Fungal counts ranged between <100 and 1.4×103 cfu/g and APCs were between 3.0×102 and 6.8×105 cfu/g. Forty-eight percent of the American ginseng root samples contained moulds and 30% showed bacterial contamination. MY counts were between <100 and 4.3×105 cfu/g whereas APCs were between <100 and 4.5×104 cfu/g. A. flavus was isolated from 9% and Penicillium spp. were recovered from 39% of the tested samples. This is the first report of A. flavus contamination in ginseng supplements. No moulds or yeasts were found in ginseng extract, but 50% of these samples contained bacteria at levels ranging between <100 and 1.0×103 cfu/g. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Prokaryotes
KW - Cryptogams
KW - Leavening agents
KW - Ginseng
KW - APCs
KW - Ginseng supplements
KW - Moulds
KW - Yeasts
N1 - Accession Number: 20398092; Tournas, V.H. 1; Email Address: vtournas@cfsan.fda.gov; Katsoudas, Eugenia 2; Miracco, E.J. 3; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; 2: North East Regional Laboratory, Food and Drug Administration, 158-15 Liberty Ave., Jamaica, NY 11433, USA; 3: University of Delaware, Newark, DE 19711, USA; Issue Info: Apr2006, Vol. 108 Issue 2, p178; Thesaurus Term: Prokaryotes; Thesaurus Term: Cryptogams; Subject Term: Leavening agents; Subject Term: Ginseng; Author-Supplied Keyword: APCs; Author-Supplied Keyword: Ginseng supplements; Author-Supplied Keyword: Moulds; Author-Supplied Keyword: Yeasts; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2005.11.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Maisel, William H.
AU - Moynahan, Megan
AU - Zuckerman, Bram D.
AU - Gross, Thomas P.
AU - Tovar, Oscar H.
AU - Tillman, Donna-Bea
AU - Schultz, Daniel B.
T1 - Pacemaker and ICD Generator Malfunctions.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/04/26/
VL - 295
IS - 16
M3 - Article
SP - 1901
EP - 1906
SN - 00987484
AB - The article presents a 2006 study of the occurrence of malfunctions in pacemakers and implantable cardio-defibrillators (ICDs) as reported to the Food and Drug Administration by manufacturers from 1990-2002. The design of the study is discussed, including the conditions under which implant malfunctions were blamed for deaths, as well as the definition of malfunction for the sake of the study. The findings of the study are analysed in detail, and it is concluded that ICDs and pacemakers are generally safe implements, but they do have risks.
KW - IMPLANTED cardiovascular instruments
KW - IMPLANTABLE cardioverter-defibrillators
KW - CARDIAC pacemakers
KW - HEART diseases -- Treatment
KW - EQUIPMENT & supplies
KW - RESEARCH
KW - MEDICAL equipment
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20576668; Maisel, William H. 1 Moynahan, Megan 2 Zuckerman, Bram D. 2 Gross, Thomas P. 2 Tovar, Oscar H. 2 Tillman, Donna-Bea 2 Schultz, Daniel B. 2; Affiliation: 1: Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 2: US Food and Drug Administration, Center for Devices and Radiologic Health, Rockville, Md; Source Info: 4/26/2006, Vol. 295 Issue 16, p1901; Subject Term: IMPLANTED cardiovascular instruments; Subject Term: IMPLANTABLE cardioverter-defibrillators; Subject Term: CARDIAC pacemakers; Subject Term: HEART diseases -- Treatment; Subject Term: EQUIPMENT & supplies; Subject Term: RESEARCH; Subject Term: MEDICAL equipment; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garcia, Alonzo D.
AU - Otero, Joel
AU - Lebowitz, Jacob
AU - Shuck, Peter
AU - Moss, Bernard
T1 - Quaternary Structure and Cleavage Specificity of a Poxvirus Holliday Junction Resolvase.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/04/28/
VL - 281
IS - 17
M3 - Article
SP - 11618
EP - 11626
SN - 00219258
AB - Recently, poxviruses were found to encode a protein with signature motifs present in the RuvC family of Holliday junction (HJ) resolvases, which have a key role in homologous recombination in bacteria. The vaccinia virus homolog A22 specifically cleaved synthetic HJ DNA in vitro and was required for the in vivo resolution of viral DNA concatemers into unit-length genomes with hairpin telomeres, It was of interest to further characterize a poxvirus resolvase in view of the low sequence similarity with RuvC, the absence of virus-encoded RuvA and RuvB to interact with, and the different functions of the viral and bacterial resolvases. Because purified A22 aggregated severely, studies were carried out with maltose-binding protein fused to A22 as well as to RuvC. Using gel filtration, chemical cross-linking, analytical ultracentrifugation, and light scattering, we demonstrated that A22 and RuvC are homodimers in solution. Furthermore, the dimeric form of the resolvase associated with HJ DNA, presumably facilitating the symmetrical cleavage of such structures. Like RuvC, A22 symmetrically cleaved fixed HJ junctions as well as junctions allowing strand mobility. Unlike RuvC and other members of the family, however, the poxvirus enzyme exhibited little cleavage sequence specificity. Structural and enzymatic similarities of poxvirus, bacterial, and fungal mitochondrial HJ resolvases are consistent with their predicted evolutionary relationship based on sequence analysis. The absence of a homologous resolvase in mammalian cells makes these microbial enzymes excellent potential therapeutic targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POXVIRUSES
KW - VACCINIA
KW - DNA
KW - PROTEINS
KW - BACTERIA
KW - MITOCHONDRIA
N1 - Accession Number: 21074784; Garcia, Alonzo D. 1,2 Otero, Joel 1,3 Lebowitz, Jacob 4 Shuck, Peter 4 Moss, Bernard 1; Email Address: bmoss@nih.gov; Affiliation: 1: Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 2: Laboratory of DNA Viruses, Division of Viral Products, HFM-457, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Bethesda, MD 20892 3: Cell and Molecular Biology Program, Baylor College of Medicine, One Baylor Plaza, Rm. N1130, Houston, TX 77030 4: Division of Bioengineering and Physical Science, Office of Research Services, National Institutes of Health, Bethesda, Maryland 20892; Source Info: 4/28/2006, Vol. 281 Issue 17, p11618; Subject Term: POXVIRUSES; Subject Term: VACCINIA; Subject Term: DNA; Subject Term: PROTEINS; Subject Term: BACTERIA; Subject Term: MITOCHONDRIA; Number of Pages: 9p; Illustrations: 15 Color Photographs, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M600182200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weisz, Adrian
AU - Wright, Pamela R.
AU - Andrzejewski, Denis
AU - Meyers, Martin B.
AU - Glaze, Kerri
AU - Mazzola, Eugene J.
T1 - Identification of the decarboxylated analog of tetrabromotetrachloro-fluorescein and its quantification in the color additives D&C Red Nos. 27 and 28 (phloxine B) using high-performance liquid chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/04/28/
VL - 1113
IS - 1/2
M3 - Article
SP - 186
EP - 190
SN - 00219673
AB - Abstract: The present work describes (a) the identification and characterization of an impurity, 2,4,5,7-tetrabromo-6-hydroxy-9-(2,3,4,5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX), in the color additives D&C Red Nos. 27 and 28 (phloxine B) and (b) the determination of the extent and level of BCPX contamination in certified lots of these colors. For these purposes, BCPX (a compound not previously reported in the literature) was synthetically prepared. Test portions from 42 certified lots of D&C Red Nos. 27, 28 and 27 lakes were analyzed for BCPX using an HPLC method that included gradient elution and UV–vis photodiode array detection. Those lots were submitted for certification by both domestic (six) and foreign (six) manufacturers during the past 4 years. Of the test portions analyzed, 32 (76.2%) contained BCPX in amounts ranging from 0.01 to 3.21%. The remaining 10 test portions (23.8%) contained no detectable BCPX or less than 0.008%, which is the limit of quantification for the present method. The analyses revealed substantial differences in the level of BCPX across different manufacturers. The wide range of BCPX levels found in the analyzed lots suggests that the presence of BCPX in D&C Red Nos. 27 and 28 may be avoided or significantly reduced during the manufacturing process. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Additives
KW - Chromatographic analysis
KW - Photodiodes
KW - High performance liquid chromatography
KW - 2
KW - 2,4,5,7-Tetrabromo-6-hydroxy-9-(2,3,4,5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX)
KW - 3
KW - 4
KW - 5
KW - 5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX)
KW - 7-Tetrabromo-6-hydroxy-9-(2
KW - Color Additives
KW - D&C Red No. 27
KW - D&C Red No. 28
KW - HPLC
KW - Phloxine B
N1 - Accession Number: 20401677; Weisz, Adrian 1; Email Address: aweisz@cfsan.fda.gov; Wright, Pamela R. 1; Andrzejewski, Denis 2; Meyers, Martin B. 1; Glaze, Kerri 1; Mazzola, Eugene J. 2; Affiliations: 1: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; 2: Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Issue Info: Apr2006, Vol. 1113 Issue 1/2, p186; Thesaurus Term: Additives; Thesaurus Term: Chromatographic analysis; Subject Term: Photodiodes; Subject Term: High performance liquid chromatography; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2,4,5,7-Tetrabromo-6-hydroxy-9-(2,3,4,5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX); Author-Supplied Keyword: 3; Author-Supplied Keyword: 4; Author-Supplied Keyword: 5; Author-Supplied Keyword: 5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX); Author-Supplied Keyword: 7-Tetrabromo-6-hydroxy-9-(2; Author-Supplied Keyword: Color Additives; Author-Supplied Keyword: D&C Red No. 27; Author-Supplied Keyword: D&C Red No. 28; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Phloxine B; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.chroma.2006.02.016
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - di Fabio, Giovanni
AU - Randazzo, Antonio
AU - D'Onofrio, Jennifer
AU - Ausín, Cristina
AU - Pedroso, Enrique
AU - Grandas, Anna
AU - de Napoli, Lorenzo
AU - Montesarchio, Daniela
T1 - Cyclic Phosphate-Linked Oligosaccharides: Synthesis and Conformational Behavior of Novel Cyclic Oligosaccharide Analogues.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2006/04/28/
VL - 71
IS - 9
M3 - Article
SP - 3395
EP - 3408
SN - 00223263
AB - CyPLOS (cyclic phosphate-linked oligosaccharides), that is, novel cyclic oligosaccharide surrogates, consisting of two, three, and four phenyl-β-D-glucopyranoside units, 4,6-linked through stable phosphodiester bonds, were prepared by a straightforward and efficient solid-phase protocol. The assembly of the linear precursors was achieved by standard phosphoramidite chemistry on an automated DNA synthesizer, using a suitably protected 4-phosphoramidite derivative of D-glucose as the building block. For the crucial cyclization step a phosphotriester methodology was exploited, followed by a mild basic treatment releasing the desired cyclic molecules in solution in a highly pure form. The cyclic dimer and trimer were also independently prepared by classical solution synthesis, basically following the same approach. The solution structural preferences of the cyclic dimer and trimer, obtained by detailed NMR analysis, are also reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLIGOSACCHARIDES
KW - CYCLIC peptides
KW - ORGANIC cyclic compounds
KW - PHOSPHODIESTERS
KW - ORGANOPHOSPHORUS compounds
KW - DIMERS
N1 - Accession Number: 20808149; di Fabio, Giovanni 1 Randazzo, Antonio 2 D'Onofrio, Jennifer 1 Ausín, Cristina 3,4 Pedroso, Enrique 3 Grandas, Anna 3 de Napoli, Lorenzo 1 Montesarchio, Daniela 1; Email Address: montesar@unina.it; Affiliation: 1: Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli "Federico II", Complesso Universitario di Monte S. Angelo, via Cynthia, 4, I-80126 Napoli, Italy 2: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II", via Domenico Montesano, 49, I-80131 Napoli, Italy 3: Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Martí i Franquès I-11, E-08028 Barcelona, Spain 4: Laboratory of Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892; Source Info: 4/28/2006, Vol. 71 Issue 9, p3395; Subject Term: OLIGOSACCHARIDES; Subject Term: CYCLIC peptides; Subject Term: ORGANIC cyclic compounds; Subject Term: PHOSPHODIESTERS; Subject Term: ORGANOPHOSPHORUS compounds; Subject Term: DIMERS; Number of Pages: 14p; Illustrations: 1 Black and White Photograph, 7 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sedrakyan, Artyom
AU - Atkins, David
AU - Treasure, Tom
T1 - The risk of aprotinin: a conflict of evidence.
JO - Lancet
JF - Lancet
Y1 - 2006/04/29/
VL - 367
IS - 9520
M3 - Article
SP - 1376
EP - 1377
PB - Lancet
SN - 00995355
AB - The article attempts the reconcile the results of two studies on the use of the antifibrinolytic aprotinin in heart surgery patients. An initial randomized clinical trial showed that aprotinin reduced the risk of blood loss and need for transfusion. A observational study by Denis Mangano et al. reported a doubling in the frequency of cardiac, renal and cerebral complications in patients treated with aprotinin. The article considers whether the observational study was biased in a way that did not affect the randomized trials or if the randomized trials were not applicable to patients who receive aprotinin in real practice.
KW - APROTININ
KW - CARDIAC surgery
KW - PATIENTS
KW - ANTICOAGULANTS (Medicine)
KW - MEDICAL research
KW - MEDICAL experimentation on humans
KW - MANGANO, Dennis
N1 - Accession Number: 20603227; Sedrakyan, Artyom 1 Atkins, David 1 Treasure, Tom 2; Email Address: tom.treasure@ukgateway.net; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland, USA 2: Thoracic Unit, Guy's Hospital, London SE1 9RT, UK; Source Info: 4/29/2006, Vol. 367 Issue 9520, p1376; Subject Term: APROTININ; Subject Term: CARDIAC surgery; Subject Term: PATIENTS; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: MEDICAL research; Subject Term: MEDICAL experimentation on humans; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: MANGANO, Dennis; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1016/S0140-6736(06)68590-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106115607
T1 - The risk of aprotinin: a conflict of evidence.
AU - Sedrakyan A
AU - Atkins D
AU - Treasure T
Y1 - 2006/04/29/
N1 - Accession Number: 106115607. Language: English. Entry Date: 20070706. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Aprotinin -- Adverse Effects
KW - Heart Surgery -- Mortality
KW - Hemorrhage -- Drug Therapy
SP - 1376
EP - 1377
JO - Lancet
JF - Lancet
JA - LANCET
VL - 367 North American Edition
IS - 9520
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 16650632.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sigaev, Gennady
AU - Tolchinsky, Alexander
AU - Sigaev, Vladimir
AU - Soloviev, Konstantin
AU - Varfolomeev, Alexander
AU - Chen, Bean
T1 - Development of a Cyclone-Based Aerosol Sampler with Recirculating Liquid Film: Theory and Experiment.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2006/05//
VL - 40
IS - 5
M3 - Article
SP - 293
EP - 308
SN - 02786826
AB - This article describes the theoretical considerations, design criteria, and experimental performance of a cyclone-based, liquid-film, bioaerosol sampler. Different from conventional cyclones, this novel sampler draws air tangentially into the bottom of a swirling cyclone, creating a negative pressure differential which causes continuous suction of sorption liquid from its reservoir into the cyclone. The liquid swirls with the air vortex and rises spirally along the sampler wall in the form of a thin film. In the presence of an excess pressure differential, the liquid goes over the upper edge of the cyclone (overflow mode) and flows back to the bottom of the sampler. As a result, there is a continuous circulation of the sorption liquid in the sampler, which enhances the efficacy of capturing viable aerosol particles from incoming air. In this study, mathematical models using simplified Navier-Stokes equations are developed to describe the behavior of the airflow, the formation of the liquid film, and the precipitation process of the aerosol particles. Numerical solutions are presented as an approximation to these complex air and liquid flow streams in the whirlwind cyclone. Based on the theoretical assessment, practical design criteria for a novel sampler were formulated and a series of prototype samplers were fabricated and evaluated. In this report, experimental findings concerning the thickness of the air vortex, the pressure profile in the cyclone, and the apex height of the liquid film are presented. The results are in good agreement with theoretical prediction. However, the theory seems to overestimate the capturing efficiency for particles around the cutoff size (in the study, 1–2 µm) when comparing with data obtained from the experiments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIQUID films
KW - THIN films
KW - AEROSOLS (Sprays)
KW - CYCLONES
KW - NAVIER-Stokes equations
KW - PARTIAL differential equations
KW - VISCOUS flow
KW - AIR flow
KW - NUMERICAL analysis
N1 - Accession Number: 20070231; Sigaev, Gennady 1 Tolchinsky, Alexander 2 Sigaev, Vladimir 2 Soloviev, Konstantin 2 Varfolomeev, Alexander 2 Chen, Bean 3; Email Address: bdc4@cdc.gov; Affiliation: 1: Division for Biopreparations Drying, State Research Centre, State Research Institute for High-Pure Biopreparations, St. Petersburg, Russia 2: Division for Aerosol Toxicometry, Research Centre for Toxicology and Hygienic Regulation of Biopreparations, Serpukhov, Russia 3: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: May2006, Vol. 40 Issue 5, p293; Subject Term: LIQUID films; Subject Term: THIN films; Subject Term: AEROSOLS (Sprays); Subject Term: CYCLONES; Subject Term: NAVIER-Stokes equations; Subject Term: PARTIAL differential equations; Subject Term: VISCOUS flow; Subject Term: AIR flow; Subject Term: NUMERICAL analysis; Number of Pages: 16p; Illustrations: 1 Color Photograph, 2 Black and White Photographs, 2 Diagrams, 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/02786820600596891
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choi, S.
AU - Morrow-Howell, N.
AU - Proctor, E.
T1 - Configuration of services used by depressed older adults.
JO - Aging & Mental Health
JF - Aging & Mental Health
Y1 - 2006/05//
VL - 10
IS - 3
M3 - Article
SP - 240
EP - 249
PB - Routledge
SN - 13607863
AB - As a more comprehensive service use measure, this study identifies service use configurations based on the use of 17 services. Factors associated with service use configurations are examined guided by the Andersen and Network Episode models. Self-report data at admission and at six-month follow-up were collected, along with information from medical charts among 140 older adults hospitalized for major depression. The data document service access and levels of use in three sectors of care (psychiatric, medical, and psychosocial services) and assess need, predisposing, enabling, and social network factors associated with use. Three distinct service use configurations were identified with cluster analysis: (1) home care users ; (2) moderate users of outpatient mental health services ; and (3) heavy users of all formal services . Rather than psychiatric needs, post-acute service use was related to: (1) concurrent physical conditions; (2) the availability of formal and informal services; and (3) financial stability. No difference in psychiatric outcomes was found by service use configuration. It is important to understand service use patterns as a measure of service use, given the co-occurring medical, psychiatric, and psychosocial conditions of older adults and corresponding needs in multiple sectors of care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aging & Mental Health is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER people -- Mental health
KW - MENTAL depression
KW - MENTAL health services
KW - SOCIAL networks
KW - PREVENTIVE mental health services for older people
N1 - Accession Number: 20917173; Choi, S. 1 Morrow-Howell, N. 1 Proctor, E. 1; Affiliation: 1: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Missouri, USA; Source Info: May2006, Vol. 10 Issue 3, p240; Subject Term: OLDER people -- Mental health; Subject Term: MENTAL depression; Subject Term: MENTAL health services; Subject Term: SOCIAL networks; Subject Term: PREVENTIVE mental health services for older people; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/13607860500310591
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20917173&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106355460
T1 - Configuration of services used by depressed older adults.
AU - Choi S
AU - Morrow-Howell N
AU - Proctor E
Y1 - 2006/05//
N1 - Accession Number: 106355460. Language: English. Entry Date: 20061103. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Geriatric Depression Scale (GDS); Mini-Mental Status Examination (MMSE) (Folstein et al); Global Assessment of Functioning Scale (GAF); Instrumental Activities of Daily Living Scale (IADL); Brief Psychiatric Rating Scale (BPRS) (Hay et al); Cumulative Illness Rating Scale-geriatric (CIRS-G) (Miller et al); Duke Life Event Scale (Hughes et al); OARS Social Resources Rating Scale (Kane and Kane); Multinoma Community Ability Scale (MCAS) (Barker et al). Grant Information: Supported by the Center for Mental Health Services Research, Washington University in St. Louis through an award from the National Institute of Mental Health (#5R24MH50857-04). NLM UID: 9705773.
KW - Depression -- Therapy
KW - Geriatric Psychiatry
KW - Mental Health Services -- Utilization
KW - Activities of Daily Living
KW - Analysis of Covariance
KW - Chi Square Test
KW - Descriptive Statistics
KW - Funding Source
KW - Geriatric Depression Scale
KW - Health Services Research
KW - Multiple Regression
KW - Multivariate Analysis of Covariance
KW - P-Value
KW - Prospective Studies
KW - Sample Size
KW - Scales
KW - Human
SP - 240
EP - 249
JO - Aging & Mental Health
JF - Aging & Mental Health
JA - AGING MENT HEALTH
VL - 10
IS - 3
CY - Oxfordshire,
PB - Routledge
AB - As a more comprehensive service use measure, this study identifies service use configurations based on the use of 17 services. Factors associated with service use configurations are examined guided by the Andersen and Network Episode models. Self-report data at admission and at six-month follow-up were collected, along with information from medical charts among 140 older adults hospitalized for major depression. The data document service access and levels of use in three sectors of care (psychiatric, medical, and psychosocial services) and assess need, predisposing, enabling, and social network factors associated with use. Three distinct service use configurations were identified with cluster analysis: (1) home care users ; (2) moderate users of outpatient mental health services ; and (3) heavy users of all formal services . Rather than psychiatric needs, post-acute service use was related to: (1) concurrent physical conditions; (2) the availability of formal and informal services; and (3) financial stability. No difference in psychiatric outcomes was found by service use configuration. It is important to understand service use patterns as a measure of service use, given the co-occurring medical, psychiatric, and psychosocial conditions of older adults and corresponding needs in multiple sectors of care.
SN - 1360-7863
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1196, St. Louis, MO 63130; schoi@gwbmail.wustl.edu
U2 - PMID: 16777651.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106355460&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Gallo-Torres, Hugo
AU - Brinker, Allen
AU - Avigan, Mark
T1 - Alosetron: Ischemic Colitis and Serious Complications of Constipation.
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
Y1 - 2006/05//
VL - 101
IS - 5
M3 - Editorial
SP - 1080
EP - 1083
SN - 00029270
AB - Drugs such as alosetron that modulate serotonin effects by stimulating or blocking its receptors may play an important role in the treatment of some patients with irritable bowel system. In the case of alosetron, a 5HT-3 antagonist, an analysis of data from randomized clinical trials and postmarketing experiences have demonstrated a causal relationship between this drug and ischemic colitis and serious complications of constipation. Because the mechanism(s) of drug-induced ischemic colitis and possibly other forms of intestinal ischemia associated with alosetron have not been elucidated, there is need to further assess risk with regard to patient susceptibility and other factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Gastroenterology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THERAPEUTICS
KW - ISCHEMIC colitis
KW - COLITIS
KW - INTESTINAL ischemia
KW - CONSTIPATION
KW - DEFECATION disorders
KW - GASTROENTEROLOGY
N1 - Accession Number: 20785719; Gallo-Torres, Hugo 1 Brinker, Allen 2 Avigan, Mark 1; Affiliation: 1: Division of Gastroenterology Products, Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Drug Evaluation III 2: Division of Drug Risk Evaluation, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Drug Safety Silver Spring, Maryland; Source Info: May2006, Vol. 101 Issue 5, p1080; Subject Term: THERAPEUTICS; Subject Term: ISCHEMIC colitis; Subject Term: COLITIS; Subject Term: INTESTINAL ischemia; Subject Term: CONSTIPATION; Subject Term: DEFECATION disorders; Subject Term: GASTROENTEROLOGY; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1111/j.1572-0241.2006.00650.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20785719&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106220194
T1 - The Agency for Healthcare Research and Quality's National Healthcare Quality and Disparities Reports: action agendas for the nation.
AU - McNeill D
AU - Moy E
AU - Clancy CM
Y1 - 2006/05//May/Jun2006
N1 - Accession Number: 106220194. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9300756.
KW - Evaluation Research
KW - Quality of Health Care
KW - United States Agency for Healthcare Research and Quality
KW - Health Services Research
KW - Organizational Objectives
KW - United States
SP - 206
EP - 209
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 21
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 16679441.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Traeger, Marc
AU - Thompson, Alette
AU - Dickson, Elizabeth
AU - Provencio, Augustine
T1 - Bridging Disparity: A Multidisciplinary Approach for Influenza Vaccination in an American Indian Community.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/05//
VL - 96
IS - 5
M3 - Article
SP - 921
EP - 925
PB - American Public Health Association
SN - 00900036
AB - Objectives. The Whiteriver Service Unit (WRSU) used proven effective methods to conduct an influenza vaccination campaign during the 2002-2003 influenza season to bridge the vaccination gap between American Indians and Alaska Natives and the US population as a whole. Methods. In our vaccination program, we used a multidisciplinary approach that included staff and community education, standing orders, vaccination of hospitalized patients, and employee, outpatient, community, and home vaccinations without financial barriers. Results. WRSU influenza vaccination coverage rates among persons aged 65 years and older, those aged 50 to 64 years, and those with diabetes were 71.8%, 49.6%, and 70.2%, respectively, during the 2002-2003 influenza season. We administered most vaccinations to persons aged 65 years and older through the outpatient clinics (63.6%) and public health nurses (30.0%). The WRSU employee influenza vaccination rate was 72.8%. Conclusions. We achieved influenza vaccination rates in targeted groups of an American Indian population that are comparable to or higher than rates in other US populations. Our system may be a useful model for other facilities attempting to bridge disparity for influenza vaccination. (Am J Public Health. 2006;96: 921-925.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA -- Vaccination
KW - VACCINATION
KW - COMMUNICABLE diseases -- Prevention
KW - HEALTH education
KW - HEALTH promotion
KW - NATIVE Americans
N1 - Accession Number: 20727779; Traeger, Marc 1; Email Address: marc.traeger@mail.ihs.gov Thompson, Alette 1 Dickson, Elizabeth 1 Provencio, Augustine 1; Affiliation: 1: Whiteriver Service Unit, Indian Health Service, PO Box 860, Whiteriver, AZ 85941; Source Info: May2006, Vol. 96 Issue 5, p921; Subject Term: INFLUENZA -- Vaccination; Subject Term: VACCINATION; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: HEALTH education; Subject Term: HEALTH promotion; Subject Term: NATIVE Americans; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article; Full Text Word Count: 4388
L3 - 10.2105/AJPH.2004.049882
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20727779&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106460389
T1 - Bridging disparity: a multidisciplinary approach for influenza vaccination in an American Indian community.
AU - Traeger M
AU - Thompson A
AU - Dickson E
AU - Provencio A
Y1 - 2006/05//
N1 - Accession Number: 106460389. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Health Services Accessibility
KW - Health Services, Indigenous
KW - Immunization Programs
KW - Influenza Vaccine
KW - Multidisciplinary Care Team
KW - Aged
KW - Aged, 80 and Over
KW - Ambulatory Care
KW - Arizona
KW - Community Health Nursing
KW - Comparative Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Diabetic Patients
KW - Health Education
KW - Health Personnel
KW - Home Visits
KW - Hospitals, Rural
KW - Interinstitutional Relations
KW - Medical Records
KW - Middle Age
KW - Native Americans
KW - Occupational Health
KW - Performance Measurement Systems
KW - Practice Guidelines -- Utilization
KW - Record Review
KW - Resource Databases, Health
KW - Human
SP - 921
EP - 925
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 96
IS - 5
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: The Whiteriver Service Unit (WRSU) used proven effective methods to conduct an influenza vaccination campaign during the 2002-2003 influenza season to bridge the vaccination gap between American Indians and Alaska Natives and the US population as a whole. METHODS: In our vaccination program, we used a multidisciplinary approach that included staff and community education, standing orders, vaccination of hospitalized patients, and employee, outpatient, community, and home vaccinations without financial barriers. RESULTS: WRSU influenza vaccination coverage rates among persons aged 65 years and older, those aged 50 to 64 years, and those with diabetes were 71.8%, 49.6%, and 70.2%, respectively, during the 2002-2003 influenza season. We administered most vaccinations to persons aged 65 years and older through the outpatient clinics (63.6%) and public health nurses (30.0%). The WRSU employee influenza vaccination rate was 72.8%. CONCLUSIONS: We achieved influenza vaccination rates in targeted groups of an American Indian population that are comparable to or higher than rates in other US populations. Our system may be a useful model for other facilities attempting to bridge disparity for influenza vaccination.
SN - 0090-0036
AD - Whiteriver Service Unit, Indian Health Service, PO Box 860, Whiteriver, AZ 85941; marc.traeger@mail.ihs.gov
U2 - PMID: 16571714.
DO - 10.2105/AJPH.2004.049882
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106460389&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Luangtongkum, Taradon
AU - Morishita, Teresa Y.
AU - Ison, Aaron J.
AU - Shouxiong Huang
AU - McDermott, Patrick F.
AU - Qijing Zhang
T1 - Effect of Conventional and Organic Production Practices on the Prevalence and Antimicrobial Resistance of Campylobacter spp. in Poultry.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/05//
VL - 72
IS - 5
M3 - Article
SP - 3600
EP - 3607
SN - 00992240
AB - Intestinal tracts of broilers and turkeys from 10 conventional broiler farms and 10 conventional turkey farms, where antimicrobials were routinely used, and from S organic broiler farms and 5 organic turkey farms, where antimicrobials had never been used, were collected and cultured for Campylobacter species. A total of 694 Campylobacter isolates from the conventional and organic poultry operations were tested for antimicrobial resistance to nine antimicrobial agents by the agar dilution method. Although Campylobacter species were highly prevalent in both the conventional and organic poultry operations, the antimicrobial resistance rates were significantly different between the organic operations and the conventional operations. Less than 2% of Campylobacter strains isolated from organically raised poultry were resistant to fluoroquinolones, while 46% and 67% of Campylobacter isolates from conventionally raised broilers and conventionally raised turkeys, respectively, were resistant to these antimicrobials. In addition, a high frequency of resistance to erythromycin (80%), clindamycin (64%), kanamycin (76%), and ampicillin (31%) was observed among Campylobacter isolates from conventionally raised turkeys. None of the Campylobacter isolates obtained in this study was resistant to gentamicin, while a large number of the isolates from both conventional and organic poultry operations were resistant to tetracycline. Multidrug resistance was observed mainly among Campylobacter strains isolated from the conventional turkey operation (81%). Findings from this study clearly indicate the influence of conventional and organic poultry production practices on antimicrobial resistance of Campylobacter on poultry farms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - DRUG resistance
KW - CAMPYLOBACTER
KW - POULTRY
KW - BROILERS (Chickens)
KW - AGAR
KW - QUINOLONE antibacterial agents
KW - CLINDAMYCIN
KW - GENTAMICIN
N1 - Accession Number: 21064547; Luangtongkum, Taradon 1 Morishita, Teresa Y. 2; Email Address: morishita.1@osu.edu Ison, Aaron J. 2 Shouxiong Huang 3 McDermott, Patrick F. 4 Qijing Zhang 5; Affiliation: 1: Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Henry Dunant Road, Bangkok 10330, Thailand 2: Department of Veterinary Preventive Medicine, Ohio State University, 1920 Coffey Road, Columbus, Ohio 43210 3: Department of Genetics, Washington University in St. Louis, Campus Box 8232, 4566 Scott Avenue, St. Louis, MO 63110 4: Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708 5: Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1116 Veterinary Medicine Complex, Ames, IA 50011; Source Info: May2006, Vol. 72 Issue 5, p3600; Subject Term: ANTI-infective agents; Subject Term: DRUG resistance; Subject Term: CAMPYLOBACTER; Subject Term: POULTRY; Subject Term: BROILERS (Chickens); Subject Term: AGAR; Subject Term: QUINOLONE antibacterial agents; Subject Term: CLINDAMYCIN; Subject Term: GENTAMICIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 112320 Broilers and Other Meat Type Chicken Production; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; Number of Pages: 8p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1128/AEM.72.5.3600-3607.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malone, Ronald F.
AU - Bergeron, Jon
AU - Cristina, Chad M.
T1 - Linear versus Monod representation of ammonia oxidation rates in oligotrophic recirculating aquaculture systems
JO - Aquacultural Engineering
JF - Aquacultural Engineering
Y1 - 2006/05//
VL - 34
IS - 3
M3 - Article
SP - 214
EP - 223
SN - 01448609
AB - Abstract: Monod kinetics are widely used to model nitrifying biofilters. However, these kinetics are incapable of representing the collapse of volumetric TAN conversion rate (VTR) under high organic loadings. Failure to recognize the underlying heterotrophic interference can lead to calibration issues as a single Monod function is applied across contrasting levels of carbon loading. This, plus an historic bias towards the analysis of peak carrying capacities leave modelers poorly prepared to serve the needs of a mariculture industry demanding oligotrophic designs for broodstock maturation and larval/fingerling production. Consequently, data was generated by a Monte Carlo technique under the assumption of heterotrophic inhibition to nitrification. The data was used to compare the accuracy of calibration of the Monod relationship using the traditional Lineweaver–Burke and Eadie–Hofstee calibration methods against direct linear regression for low substrate (mesotrophic/oligotrophic) regimes. The results indicate that a simple linear relationship with a zero intercept, calibrated on data ranging from 0.1 to 0.5g-TANm−3, is most suitable for the representation of the mesotrophic/oligotrophic performance of nitrifying biofilters based on a comparison of SSE for both the Monte Carlo and field data analyzed herein. Additionally, the coefficient of variation was found to be between 7 and 8% for the parameter τ, which is the slope of the linear relationship between total ammonia nitrogen (TAN) and VTR while the CV for the Monod parameters ranged between 22 and 143% for VTRmax and between 29 and 137% for the apparent half-saturation constant showing the improved stability of the linear model to that of the Monod model. [Copyright &y& Elsevier]
AB - Copyright of Aquacultural Engineering is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - NITRIFYING bacteria
KW - MARINE biology
KW - BIOFILMS
KW - Broodstock
KW - Inhibition
KW - Linear regression
KW - Modeling
KW - Monod model
KW - Nitrification kinetics
KW - Oligotrophic
N1 - Accession Number: 20401615; Malone, Ronald F. 1; Email Address: RMalone@lsu.edu Bergeron, Jon 2 Cristina, Chad M. 3; Affiliation: 1: Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, USA 2: U.S. Public Health Service, 4060 Wheaton Way Ste. E., Bremerton, WA 98310, USA 3: Department of Civil Engineering, University of South Alabama, Mobile, AL 36688, USA; Source Info: May2006, Vol. 34 Issue 3, p214; Subject Term: REGRESSION analysis; Subject Term: NITRIFYING bacteria; Subject Term: MARINE biology; Subject Term: BIOFILMS; Author-Supplied Keyword: Broodstock; Author-Supplied Keyword: Inhibition; Author-Supplied Keyword: Linear regression; Author-Supplied Keyword: Modeling; Author-Supplied Keyword: Monod model; Author-Supplied Keyword: Nitrification kinetics; Author-Supplied Keyword: Oligotrophic; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.aquaeng.2005.08.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - In‐Sook J. Shin
AU - Alan N. Baer
AU - Hyon J. Kwon
AU - Elektra J. Papadopoulos
AU - Jeffrey N. Siegel
T1 - Guillain‐Barré and Miller Fisher syndromes occurring with tumor necrosis factor α antagonist therapyPresented in part at the 57th Annual Meeting of the American Academy of Neurology, Miami, FL, April 12, 2005.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2006/05//
VL - 54
IS - 5
M3 - Article
SP - 1429
EP - 1434
SN - 00043591
AB - Diverse neurologic syndromes have been described in association with tumor necrosis factor α (TNFα) antagonist therapy for inflammatory arthritides and Crohn's disease. The objective of this study was to review the occurrence and clinical features of Guillain‐Barré syndrome and its variant, the Miller Fisher syndrome, during TNFα antagonist therapy.The postmarketing database of the US Food and Drug Administration (FDA) was searched, following our experience with a patient with rheumatoid arthritis in whom the Miller Fisher syndrome variant of the Guillain‐Barré syndrome developed while he was receiving infliximab therapy.Our index patient had a neurologic illness defined initially by ataxia and dysarthria, which fluctuated in relation to each subsequent infliximab infusion and, after 6 months, culminated in areflexic flaccid quadriplegia. In addition, 15 patients in whom Guillain‐Barré syndrome developed following TNFα antagonist therapy were identified from the FDA database. Guillain‐Barré syndrome developed following infliximab therapy in 9 patients, following etanercept therapy in 5 patients, and following adalimumab therapy in 1 patient. Among the 13 patients for whom followup data were available, 1 patient experienced no resolution, 9 patients had partial resolution, and 3 patients had complete resolution of Guillain‐Barré syndrome following therapy.An association of Guillain‐Barré syndrome with TNFα antagonist therapy is supported by the worsening of neurologic symptoms that occurred in our index patient following each infusion of infliximab, and by the temporal association of this syndrome with TNFα antagonist therapy in 15 other patients. An acute or subacute demyelinating polyneuropathy should be considered a potential adverse effect of TNFα antagonist therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Arthritis & Rheumatism is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - CROHN'S disease
KW - RHEUMATOID arthritis
KW - AUTOIMMUNE diseases
KW - GUILLAIN-Barre syndrome
N1 - Accession Number: 21047448; In‐Sook J. Shin 1 Alan N. Baer 1 Hyon J. Kwon 2 Elektra J. Papadopoulos 2 Jeffrey N. Siegel 2; Affiliation: 1: State University of New York at Buffalo 2: Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland; Source Info: May2006, Vol. 54 Issue 5, p1429; Subject Term: TUMOR necrosis factor; Subject Term: CROHN'S disease; Subject Term: RHEUMATOID arthritis; Subject Term: AUTOIMMUNE diseases; Subject Term: GUILLAIN-Barre syndrome; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moss, Julie
T1 - Labeling of trans fatty acid content in food, regulations and limits—The FDA view
JO - Atherosclerosis (Supplements)
JF - Atherosclerosis (Supplements)
Y1 - 2006/05//
VL - 7
IS - 2
M3 - Article
SP - 57
EP - 59
SN - 15675688
AB - Abstract: With the scientific evidence associating trans fatty acid (TFA) intake with an increased risk of coronary heart disease (CHD), the U.S. Food and Drug Administration (FDA) issued a final rule that requires the declaration of the amount of TFA present in foods, including dietary supplements, on the nutrition label by January 1, 2006. The addition of TFA to the nutrition label will lead to the prevention of 600 to 1200 cases of CHD and 240–480 deaths each year saving $900 million to $1.8 billion per year in medical costs, lost productivity, and pain and suffering. For the purpose of nutrition labeling, TFA are defined as the sum of all unsaturated fatty acids that contain one or more isolated (i.e. non-conjugated) double bonds in a trans configuration. There are many issues that FDA has yet to resolve: (1) defining nutrient content claims for “free” and “reduced” levels of trans fat, (2) placing limits on the amount of TFA in conjunction with saturated fat limits for nutrient content claims, health claims, and disclosure and disqualifying levels, (3) a daily value, and (4) a possible footnote or disclosure statement to enhance consumer understanding of cholesterol raising lipids. FDA issued an Advanced Notice of Proposed Rulemaking (ANPR) requesting comments on the unresolved issues. FDA will also be conducting consumer research to determine consumer understanding of various TFA labeling possibilities. Comments to the ANPR, results of consumer research and current science will be used by FDA to resolve these issues and to determine future rulemaking for TFA labeling. [Copyright &y& Elsevier]
AB - Copyright of Atherosclerosis (Supplements) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANS fatty acids
KW - FATTY acids in human nutrition
KW - FOOD labeling -- Law & legislation
KW - FOOD -- Packaging
KW - FOOD additives
KW - CORONARY heart disease
KW - FDA
KW - Labeling
KW - Nutrition
KW - Trans fatty acids
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 21265980; Moss, Julie 1; Email Address: Julie.Moss@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; Source Info: May2006, Vol. 7 Issue 2, p57; Subject Term: TRANS fatty acids; Subject Term: FATTY acids in human nutrition; Subject Term: FOOD labeling -- Law & legislation; Subject Term: FOOD -- Packaging; Subject Term: FOOD additives; Subject Term: CORONARY heart disease; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Labeling; Author-Supplied Keyword: Nutrition; Author-Supplied Keyword: Trans fatty acids; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.atherosclerosissup.2006.04.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martin, Paul J.
AU - Weisdorf, Daniel
AU - Przepiorka, Donna
AU - Hirschfeld, Steven
AU - Farrell, Ann
AU - Rizzo, J. Douglas
AU - Foley, Ronan
AU - Socie, Gerard
AU - Carter, Shelly
AU - Couriel, Daniel
AU - Schultz, Kirk R.
AU - Flowers, Mary E.D.
AU - Filipovich, Alexandra H.
AU - Saliba, Rima
AU - Vogelsang, Georgia B.
AU - Pavletic, Steven Z.
AU - Lee, Stephanie J.
T1 - National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2006/05//
VL - 12
IS - 5
M3 - Article
SP - 491
EP - 505
SN - 10838791
AB - Abstract: The complexity of chronic graft-versus-host disease (GVHD) and the lack of established research methods have made it difficult to design, conduct, and analyze clinical trials involving subjects with this disease, even when promising treatment options are available. This consensus document was developed to offer an approach for overcoming these obstacles. Clinical trials in chronic GVHD should adhere to principles of good trial design and practice. Inclusion and exclusion criteria should allow as many subjects to participate as possible without compromising the interpretation of results. Pre-enrollment assessment of chronic GVHD characteristics should be standardized. The protocol should provide clear guidance about administration of study medication and other interventions. Methods of assessing response should be defined and validated in advance. Efficacy endpoints should be selected to reflect clinical benefit. Expert biostatistical support is needed to ensure the validity and reliability of trial results. The use of consistent standards in clinical trial designs to evaluate agents that have activity in pathogenic pathways could facilitate advances in the treatment of chronic GVHD. [Copyright &y& Elsevier]
AB - Copyright of Biology of Blood & Marrow Transplantation is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - GRAFT versus host disease
KW - RELIABILITY (Personality trait)
KW - CLINICAL medicine
KW - Allogeneic hematopoietic cell transplantation
KW - Chronic graft-versus-host disease
KW - Clinical trials
KW - Consensus
KW - Design
N1 - Accession Number: 20557539; Martin, Paul J. 1; Email Address: pmartin@fhcrc.org Weisdorf, Daniel 2 Przepiorka, Donna 3 Hirschfeld, Steven 4 Farrell, Ann 4 Rizzo, J. Douglas 5 Foley, Ronan 6 Socie, Gerard 7 Carter, Shelly 8 Couriel, Daniel 9 Schultz, Kirk R. 10 Flowers, Mary E.D. 1 Filipovich, Alexandra H. 11 Saliba, Rima 9 Vogelsang, Georgia B. 12 Pavletic, Steven Z. 13 Lee, Stephanie J. 1; Affiliation: 1: Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 2: University of Minnesota, Minneapolis, Minnesota 3: University of Tennessee, Memphis, Tennessee 4: US Food and Drug Administration, Rockville, Maryland 5: Medical College of Wisconsin, Milwaukee, Wisconsin 6: McMaster University, Hamilton, Ontario, Canada 7: Hopital St. Louis, Paris, France 8: EMMES Corporation, Rockville, Maryland 9: University of Texas M.D. Anderson Cancer Center, Houston, Texas 10: British Columbia Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada 11: Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 12: Johns Hopkins University School of Medicine, Baltimore, Maryland 13: National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: May2006, Vol. 12 Issue 5, p491; Subject Term: CLINICAL trials; Subject Term: GRAFT versus host disease; Subject Term: RELIABILITY (Personality trait); Subject Term: CLINICAL medicine; Author-Supplied Keyword: Allogeneic hematopoietic cell transplantation; Author-Supplied Keyword: Chronic graft-versus-host disease; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Consensus; Author-Supplied Keyword: Design; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.bbmt.2006.03.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106165526
T1 - Wireless technology: communications and challenges in healthcare.
AU - Witters D
AU - Witters, Don
Y1 - 2006/05//May/Jun2006
N1 - Accession Number: 106165526. Language: English. Entry Date: 20071005. Revision Date: 20161117. Publication Type: journal article; brief item. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Health Care Delivery -- Trends
KW - Health Facility Administration
KW - Wireless Communications
KW - Health Care Delivery -- Methods
KW - Telecommunications -- Trends
SP - 248
EP - 248
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 40
IS - 3
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
SN - 0899-8205
AD - Center for Devices and Radiological Health, Food and Drug Administration, USA
AD - Center for Devices and Radiological Health, Food and Drug Administration, USA.
U2 - PMID: 16796338.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mahmood, Iftekhar
T1 - Prediction of drug clearance in children from adults: a comparison of several allometric methods.
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
Y1 - 2006/05//
VL - 61
IS - 5
M3 - Article
SP - 545
EP - 557
PB - Wiley-Blackwell
SN - 03065251
AB - Aims In recent years with the advent of paediatric exclusivity and requirements to conduct clinical studies in children, the current emphasis is to find a safe and efficacious dose of a drug in children. It has been suggested that one can predict the clearance of a drug in children according to the equation: CL in the child = adult CL × (weight of the child/70)0.75. Considering the controversy surrounding the exponent of 0.75 for the prediction of clearance and lack of any systematic evaluation of the aforementioned proposal, the objectives of the study were as follows: (i) to determine if indeed the exponent 0.75 is the most suitable exponent for the prediction of clearance in children from adult data; (ii) to explore and search for other exponents that are more accurate or as good as 0.75; and (iii) to propose a new approach (if any) based on the findings of the current evaluation. Methods Six methods were used to predict clearance of drugs in children from adult data. Besides evaluating the exponent of 0.75, exponents of 0.80, 0.85 and 1.0 were also evaluated. An empirical approach based on kidney and liver weights was also examined. Based on the results of five methods, a sixth method was introduced. Results The results of the study indicate that no single method is suitable for all drugs or for all age groups. The exponents 0.75, 0.80, and 0.85 provided the same degree of accuracy or error in the prediction of clearance in children. Conclusions Since no single method is suitable for all drugs or for all age groups. A combination of approaches is suggested which may help in improving the prediction of clearance in children from adult data. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL pharmacology
KW - PEDIATRICS
KW - CHILDREN & adults
KW - DOSAGE of drugs
KW - PHARMACEUTICAL arithmetic
KW - CLINICAL medicine
KW - allometric scaling
KW - children
KW - clearance
KW - exponents
KW - root mean square error
N1 - Accession Number: 20588285; Mahmood, Iftekhar 1; Email Address: mahmoodi@cder.fda.gov; Affiliation: 1: Clinical Pharmacology and Toxicology Branch, Office of Drug Evaluation VI, Center for Drug Evaluation and Research, Food & Drug Administration, Rockville, MD, USA; Source Info: May2006, Vol. 61 Issue 5, p545; Subject Term: CLINICAL pharmacology; Subject Term: PEDIATRICS; Subject Term: CHILDREN & adults; Subject Term: DOSAGE of drugs; Subject Term: PHARMACEUTICAL arithmetic; Subject Term: CLINICAL medicine; Author-Supplied Keyword: allometric scaling; Author-Supplied Keyword: children; Author-Supplied Keyword: clearance; Author-Supplied Keyword: exponents; Author-Supplied Keyword: root mean square error; Number of Pages: 13p; Illustrations: 11 Charts; Document Type: Article
L3 - 10.1111/j.1365-2125.2006.02622.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Almoosa, Khalid F.
AU - Ryu, Jay H.
AU - Mendez, Jose
AU - Huggins, J. Terrill
AU - Young, Lisa R.
AU - Sullivan, Eugene J.
AU - Maurer, Janet
AU - McCormack, Francis X.
AU - Sahn, Steven A.
T1 - Management of Pneumothorax in Lyrnphangioleiomyomatosis: Effects on Recurrence and Lung Transplantation Complications.
JO - CHEST
JF - CHEST
Y1 - 2006/05//
VL - 129
IS - 5
M3 - Article
SP - 1274
EP - 1281
SN - 00123692
AB - The article examines the effects of the management of pneumothorax in lymphangioleiomyomatosis (LAM) on recurrence and lung transplantation complications. Sixty-six percent of patients reported at least one pneumothorax during their lifetime. Eighty-two percent had their first pneumothorax prior to a diagnosis of LAM. Seventy-three percent had at least one additional pneumothorax, either an ipsilateral recurrence or a contralateral pneumothorax. Eighteen percent reported pleural-related postoperative bleeding after lung transplantation.
KW - PNEUMOTHORAX
KW - LYMPHANGIOMYOMATOSIS
KW - LUNG transplants
KW - HEMORRHAGE
KW - DISEASE relapse
KW - lung transplantation; Iymphangioleiomyomatosis; pleurodesis; pneumothorax
N1 - Accession Number: 20973438; Almoosa, Khalid F. 1; Email Address: khalid.almoosa@uc.edu Ryu, Jay H. 2 Mendez, Jose 2 Huggins, J. Terrill 3 Young, Lisa R. 1 Sullivan, Eugene J. 4 Maurer, Janet 5 McCormack, Francis X. 1 Sahn, Steven A. 3; Affiliation: 1: Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 2: Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 3: Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC 4: US Food and Drug Administration, Rockville, MD 5: Cigna Health Care, West Granby, CT; Source Info: May2006, Vol. 129 Issue 5, p1274; Subject Term: PNEUMOTHORAX; Subject Term: LYMPHANGIOMYOMATOSIS; Subject Term: LUNG transplants; Subject Term: HEMORRHAGE; Subject Term: DISEASE relapse; Author-Supplied Keyword: lung transplantation; Iymphangioleiomyomatosis; pleurodesis; pneumothorax; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hundley, S. G.
AU - Sarrif, A.
AU - Kennedy Jr., G. L.
T1 - Absorption, Distribution, and Excretion of Ammonium Perfluorooctanoate (APFO) After Oral Administration to Various Species.
JO - Drug & Chemical Toxicology
JF - Drug & Chemical Toxicology
Y1 - 2006/05//
VL - 29
IS - 2
M3 - Article
SP - 137
EP - 145
PB - Taylor & Francis Ltd
SN - 01480545
AB - Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14 C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h (168 h in the rabbit). Substantial sex and species differences in the excretion and disposition of 14 C-radioactivity derived from 14 C-labeled APFO were observed in this study. The female rat and the male hamster excreted more than 99% of the original 14 C activity by 120 h after dosing; conversely, the male rat and the female hamster excreted only 39% and 60% of the original 14 C activity, respectively, by 120 h postdosing. The male and female rabbits excreted the 14 C activity as rapidly and completely as the female rat and the male hamster, whereas male and female mice excreted only 21% of the original 14 C activity by 120 h postdosing. The rapid excretors (female rat, male hamster, and male and female rabbits) contained negligible amounts of 14 C in organs and tissues at sacrifice. The slow excretors exhibited the highest 14 C concentrations in the blood and liver followed by the kidneys, lungs, and skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug & Chemical Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EUROPEAN rabbit
KW - RATS
KW - HAMSTERS
KW - EXCRETION
KW - SECRETION
KW - LEPORIDAE
KW - TISSUE banks
KW - CARDIOPULMONARY system
KW - URINARY organs
KW - Ammonium perfluorooctanoate (APFO)
KW - Ammonium perfluorooctanoate (APFO).
KW - Hamster distribution
KW - Mouse distribution
KW - Rabbit distribution
KW - rat distribution
N1 - Accession Number: 20617719; Hundley, S. G. 1 Sarrif, A. 2 Kennedy Jr., G. L. 2; Email Address: gerald.l.kennedy@usa.dupont.com; Affiliation: 1: Food and Drug Administration, Center for Drug and Evaluation and Research, Rockville, Maryland, USA 2: DuPont Haskell Laboratory, Newark, Delaware, USA; Source Info: 2006, Vol. 29 Issue 2, p137; Subject Term: EUROPEAN rabbit; Subject Term: RATS; Subject Term: HAMSTERS; Subject Term: EXCRETION; Subject Term: SECRETION; Subject Term: LEPORIDAE; Subject Term: TISSUE banks; Subject Term: CARDIOPULMONARY system; Subject Term: URINARY organs; Author-Supplied Keyword: Ammonium perfluorooctanoate (APFO); Author-Supplied Keyword: Ammonium perfluorooctanoate (APFO).; Author-Supplied Keyword: Hamster distribution; Author-Supplied Keyword: Mouse distribution; Author-Supplied Keyword: Rabbit distribution; Author-Supplied Keyword: rat distribution; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 621991 Blood and Organ Banks; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/01480540600561361
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beger, Richard D.
T1 - Computational modeling of biologically active molecules using NMR spectra
JO - Drug Discovery Today
JF - Drug Discovery Today
Y1 - 2006/05//
VL - 11
IS - 9/10
M3 - Article
SP - 429
EP - 435
SN - 13596446
AB - The molecular structure and NMR chemical shift information of a compound can be combined to form powerful models of biological activity. NMR spectral data and structure information can be combined on a structural template analogous to 3D-QSAR methodology or orientation independently in spectral space. Surprisingly, quantitative spectrometric data–activity relationship (QSDAR) models built on structure templates are inferior to multi-dimensional QSDAR models built in spectral space. 3D-QSDAR modeling could be useful for estimating chemical toxicity, risk assessment of environmental contaminants and drug lead-compound identifications. [Copyright &y& Elsevier]
AB - Copyright of Drug Discovery Today is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR structure
KW - NUCLEAR magnetic resonance
KW - METHODOLOGY
KW - SPECTROMETRY
KW - ORGANIC water pollutants
N1 - Accession Number: 20557976; Beger, Richard D. 1; Email Address: richard.beger@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: May2006, Vol. 11 Issue 9/10, p429; Subject Term: MOLECULAR structure; Subject Term: NUCLEAR magnetic resonance; Subject Term: METHODOLOGY; Subject Term: SPECTROMETRY; Subject Term: ORGANIC water pollutants; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.drudis.2006.03.014
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - McCune, Susan K.1
AU - Mathis, Lisa L.2
AU - Cocchetto, David M.3
AU - Ball, Karen4
AU - Rodriguez, W.5, rodriguezw@cder.fda.gov
T1 - Safer, Better, More Appropriate: Clinical Trial Design for Pediatric Drug Labels.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2006/05//
Y1 - 2006/05//
VL - 40
IS - 2
CP - 2
M3 - Article
SP - 185
EP - 195
SN - 00928615
AB - Off-label use of drugs in pediatrics remains a national and international problem. The American Academy of Pediatrics determined in 1977, and reaffirmed in 1995, that there was a moral imperative to formally study drugs in children so they "have access to important medications and receive optimal drug therapy." Congress passed legislation in 1997 that encouraged the study of patent drugs, or those with remaining exclusivity or patent protection, in pediatric patients. Manufacturers of new chemical entities could earn an incentive (in the form of pediatric exclusivity) for their product if a program of pediatric clinical research that met the requirements of a Written Request from the Food and Drug Administration was completed as scheduled. Such pediatric research must be expected to yield medically valuable information for pediatric patients. Additional legislation, the Best Pharmaceutical for Children Act, which renewed the exclusivity incentive for the "on-patent" drugs and provides a mechanism to facilitate the study of "off-patent drugs", and the Pediatric Research Equity Act address ways to encourage obtaining safety and efficacy data in pediatric patients. Pediatric drug trials require a concerted effort from academia, industry, and patient advocacy groups to obtain safety, efficacy, and pharmacokinetic data in placebo-controlled or active-controlled multicenter trials. Because of the unique nature of pediatric patients, data for pediatric drug labeling may need to be derived from creative clinical trial designs and population pharmacokinetic studies, randomized withdrawal trials, enrichment studies, as well as the utilization of extrapolation of clinical efficacy when appropriate. These novel approaches to clinical trial design as well as a discussion of more classical clinical trials are discussed in relation to pediatric clinical studies. [ABSTRACT FROM AUTHOR]
KW - Drugs
KW - Pediatrics
KW - Medicine
KW - Administration of drugs
KW - Pharmaceutical industry
KW - Pharmacokinetics
KW - American Academy of Pediatrics
KW - Clinical trial design
KW - Global partnership in drug development
KW - Off-label use of drugs
KW - Pediatric drug development
KW - Pediatric regulatory issues
N1 - Accession Number: 21103549; Authors: McCune, Susan K. 1; Mathis, Lisa L. 2; Cocchetto, David M. 3; Ball, Karen 4; Rodriguez, W. 5 Email Address: rodriguezw@cder.fda.gov; Affiliations: 1: Medical Officer, Division of Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 2: Acting Director, Division of Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; 3: US Regulatory Affairs, GlaxoSmithKline, Research Triangle Park, North Carolina; 4: President and CEO, The Sturge-Weber Foundation, Freedom, New Jersey; 5: Science Director for Pediatrics, Office of Counter-terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Subject: Drugs; Subject: Pediatrics; Subject: Medicine; Subject: American Academy of Pediatrics; Subject: Administration of drugs; Subject: Pharmaceutical industry; Subject: Pharmacokinetics; Author-Supplied Keyword: Clinical trial design; Author-Supplied Keyword: Global partnership in drug development; Author-Supplied Keyword: Off-label use of drugs; Author-Supplied Keyword: Pediatric drug development; Author-Supplied Keyword: Pediatric regulatory issues; Number of Pages: 11p; Illustrations: 1 Chart; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Wheeler, Matthew W.
AU - Park, Robert M.
AU - Bailer, A. John
T1 - COMPARING MEDIAN LETHAL CONCENTRATION VALUES USING CONFIDENCE INTERVAL OVERLAP OR RATIO TESTS.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2006/05//
VL - 25
IS - 5
M3 - Article
SP - 1441
EP - 1444
SN - 07307268
AB - Experimenters in toxicology often compare the concentration--response relationship between two distinct populations using the median lethal concentration (LC50). This comparison is sometimes done by calculating the 95% confidence interval for the LC50 for each population, concluding that no significant difference exists if the two confidence intervals overlap. A more appropriate test compares the ratio of the LC50s to 1 or the log(LC50 ratio) to 0. In this ratio test, we conclude that no difference exists in LC50s if the confidence interval for the ratio of the LC50s contains 1 or the confidence interval for the log(LC50 ratio) contains 0. A Monte Carlo simulation study was conducted to compare the confidence interval overlap test to the ratio test. The confidence interval overlap test performs substantially below the nominal α = 0.05 level, closer to p = 5 0.005; therefore, it has considerably less power for detecting true differences compared to the ratio test. The ratio-based method exhibited better type I error rates and superior power properties in comparison to the confidence interval overlap test. Thus, a ratio-based statistical procedure is preferred to using simple overlap of two independently derived confidence intervals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - MONTE Carlo method
KW - ERROR
KW - RESEARCH
KW - RISK assessment
KW - POISONING
KW - ERROR rates
KW - Fieller's method
KW - Median lethal concentration
KW - Power
KW - Significance testing
KW - Type I error rates
N1 - Accession Number: 27772892; Wheeler, Matthew W. 1; Email Address: mwheeler@cdc.gov Park, Robert M. 1 Bailer, A. John 1,2; Affiliation: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS-15, Cincinnati, Ohio 45226, USA 2: Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA; Source Info: May2006, Vol. 25 Issue 5, p1441; Subject Term: TOXICOLOGY; Subject Term: MONTE Carlo method; Subject Term: ERROR; Subject Term: RESEARCH; Subject Term: RISK assessment; Subject Term: POISONING; Subject Term: ERROR rates; Author-Supplied Keyword: Fieller's method; Author-Supplied Keyword: Median lethal concentration; Author-Supplied Keyword: Power; Author-Supplied Keyword: Significance testing; Author-Supplied Keyword: Type I error rates; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tan, Carol
AU - Sedrakyan, Artyom
AU - Browne, John
AU - Swift, Simon
AU - Treasure, Tom
T1 - The evidence on the effectiveness of management for malignant pleural effusion: a systematic review
JO - European Journal of Cardio-Thoracic Surgery
JF - European Journal of Cardio-Thoracic Surgery
Y1 - 2006/05//
VL - 29
IS - 5
M3 - Article
SP - 829
EP - 838
SN - 10107940
AB - Summary: The aim of this study was to review systematically the available evidence on pleurodesis for malignant effusion, focusing on the choice of the agents, route of delivery and other strategies to improve outcomes. Four electronic databases (MEDLINE, EMBASE, Web of Science and Cochrane Controlled Trials Register) were searched, reference lists checked and letters requesting details of unpublished trials and data sent to authors of previous trials. Studies of malignant pleural effusion in humans were selected with no language restrictions applied. Criteria for randomised clinical trial (RCT) eligibility were random allocation of patients and non-concurrent use of another experimental medication or device. Methodological quality evaluation of the trials was based on randomisation, blinding, allocation concealment and intention to treat analysis. A random effect model was used to combine the relative risk estimates of the treatment effects whenever pooling for an overall effect was considered appropriate. Forty-six RCTs with a total of 2053 patients with malignant pleural effusions were reviewed for effectiveness of pleurodesis. Talc tended to be associated with fewer recurrences when compared to bleomycin (RR, 0.64; 95% CI, 0.34–1.20) and, with more uncertainty, to tetracycline (RR, 0.50; 95% CI, 0.06–4.42). Tetracycline (or doxycycline) was not superior to bleomycin (RR, 0.92; 95% CI, 0.61–1.38). When compared with bedside talc slurry, thoracoscopic talc insufflation was associated with a reduction in recurrence (RR, 0.21; 95% CI, 0.05–0.93). Strategies such as rolling the patient after instillation of the sclerosing agent, protracted drainage of the effusion and use of larger chest tubes were not found to have any substantial advantages. Talc appears to be effective and should be the agent of choice for pleurodesis. Thoracoscopic talc insufflation is associated with fewer recurrences of effusions compared with bedside talc slurry, but this is based on two small studies. Where thoracoscopy is unavailable bedside talc pleurodesis has a high success rate and is the next best option. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Cardio-Thoracic Surgery is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLEURAL effusions
KW - PLEURA -- Diseases
KW - EXUDATES & transudates
KW - IMMUNOSUPPRESSIVE agents
KW - BLEOMYCIN
KW - TETRACYCLINE
KW - MEDICAL research
KW - THORACOSCOPY
KW - Malignant effusion
KW - Pleurodesis
KW - VATS
N1 - Accession Number: 20623246; Tan, Carol 1 Sedrakyan, Artyom 2 Browne, John 3,4 Swift, Simon 1 Treasure, Tom 1; Email Address: tom.treasure@ukgateway.net; Affiliation: 1: Thoracic Unit, Guy's Hospital, St Thomas’ Street, London SE1 9RT, United Kingdom 2: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA 3: Clinical Effectiveness Unit, Royal College of Surgeons of England, Keppel Street, London WC1E 7HT, United Kingdom 4: Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom; Source Info: May2006, Vol. 29 Issue 5, p829; Subject Term: PLEURAL effusions; Subject Term: PLEURA -- Diseases; Subject Term: EXUDATES & transudates; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: BLEOMYCIN; Subject Term: TETRACYCLINE; Subject Term: MEDICAL research; Subject Term: THORACOSCOPY; Author-Supplied Keyword: Malignant effusion; Author-Supplied Keyword: Pleurodesis; Author-Supplied Keyword: VATS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ejcts.2005.12.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Balagué, Claudia
AU - Khan, Ashraf A.
AU - Fernandez, Luisa
AU - Lía Redolfi, Ana
AU - Aquili, Virginia
AU - Voltattorni, Patricia
AU - Hofer, Claudio
AU - Ebner, Guillermo
AU - Dueñas, Susana
AU - Cerniglia, Carl E.
T1 - Occurrence of non-O157 shiga toxin-producing Escherichia coli in ready-to-eat food from supermarkets in Argentina
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/05//
VL - 23
IS - 3
M3 - Article
SP - 307
EP - 313
SN - 07400020
AB - Abstract: Between June 2000 and December 2001, 500 food samples were collected from supermarkets and shops selling ready-to-eat food in Rosario, Argentina, and examined for Escherichia coli. Forty-nine E. coli isolates from food samples were further characterized for virulence genes by multiplex polymerase chain reaction (PCR) targeting the stx1, stx2, stx2e, eaeA, CNF1, CNF2, Einv, LTI, STI, and STII genes in four groups. Out of 49 E. coli isolates screened by multiplex PCR, only 10 possessed Shiga toxin genes, stx1and stx2 genes and none possessed the other genes. The Shiga toxin positive E. coli strains (STEC) were isolated from soft, cottage cheeses, chicken with sauce and vegetables mayonase. These E. coli isolates were serogrouped and belonged to O18 (two strains), O8, O57w, O79, O44, and O128; three strains were untypeable. Pulsed-field gel electrophoresis (PFGE) with XbaI generated a unique profile for each, having 10–15 bands ranging from 50 to 500kb, except that strain ARG 20 generated small bands and was partly degraded. These strains are potential foodborne pathogens and their presence in ready-to-eat food illustrates the need to keep a careful watch for the source of pathogens and then develop methods to control them. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - ELECTROPHORESIS
KW - TOXINS
KW - HORTICULTURAL crops
KW - Multiplex pcr
KW - Non-O157 Escherichia coli
KW - Pulsed-field gel electrophoresis
KW - Ready to eat food
KW - Shiga toxin
N1 - Accession Number: 18625815; Balagué, Claudia 1 Khan, Ashraf A. 2; Email Address: Ashraf@nctr.fda.gov Fernandez, Luisa 1 Lía Redolfi, Ana 1 Aquili, Virginia 1 Voltattorni, Patricia 3 Hofer, Claudio 3 Ebner, Guillermo 3 Dueñas, Susana 3 Cerniglia, Carl E. 2; Affiliation: 1: Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentina 2: Division of Microbiology, US Food and Drug Administration, NCTR, 3900 NCTR Road., Jefferson, Arkansas 72079, USA 3: Rosario Food Institute, Rosario, Argentina; Source Info: May2006, Vol. 23 Issue 3, p307; Subject Term: ESCHERICHIA coli; Subject Term: ELECTROPHORESIS; Subject Term: TOXINS; Subject Term: HORTICULTURAL crops; Author-Supplied Keyword: Multiplex pcr; Author-Supplied Keyword: Non-O157 Escherichia coli; Author-Supplied Keyword: Pulsed-field gel electrophoresis; Author-Supplied Keyword: Ready to eat food; Author-Supplied Keyword: Shiga toxin; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fm.2005.03.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Zhan, CL;
AU - Friedman, B;
AU - Mosso, A;
AU - Pronovost, P;
T1 - Medicare payment for selected adverse events: Building the business case for investing in patient safety
CT - Medicare payment for selected adverse events: Building the business case for investing in patient safety
JO - Health Affairs
JF - Health Affairs
Y1 - 2006/05/01/
VL - 25
IS - May
SP - 1386
EP - 1393
SN - 02782715
AD - AHRQ, Rockville, MD, USA czhan@ahrq.gov
N1 - Accession Number: 43-19907; Language: English; References: 18; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Adverse Drug Reactions
N2 - This study estimates that Medicare extra payments under the hospital prospective payment system (PPS) range from about $700 per case of decubitus ulcer to $9,000 per case of postoperative sepsis in the five types of adverse events identifiable in Medicare claims. Medicare extra payment for the five types of events totals more than $300 million per year, accounting for 0.27 percent of annual Medicare hospital spending. But these extra payments cover less than a third of the extra costs incurred by hospitals in treating these adverse events. We conclude that both Medicare and hospitals gain financially by improving patient safety.
KW - Economics--drugs, adverse reactions;
KW - Hospitals--drugs, adverse reactions;
KW - Health benefit programs--medicare;
KW - Drugs, adverse reactions--costs;
KW - Interventions--medicare;
KW - Outcomes--economics;
KW - Costs--drugs, adverse reactions;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Beard, Brian B.
AU - Kainz, Wolfgang
AU - Onishi, Teruo
AU - Iyama, Takahiro
AU - Watanabe, Soichi
AU - Fujiwara, Osamu
AU - Jianqing Wang
AU - Giorgi Bit-Babik
AU - Faraone, Antonio
AU - Wiart, Joe
AU - Christ, Andreas
AU - Kuster, Niels
AU - Ae-Kyoung Lee
AU - Kroeze, Hugo
AU - Siegbahn, Martin
AU - Keshvari, Jafar
AU - Abrishamkar, Houman
AU - Simon, Winfried
AU - Manteuffel, Dirk
AU - Nikoloski, Neviana
T1 - Comparisons of Computed Mobile Phone Induced SAR in the SAM Phantom to That in Anatomically Correct Models of the Human Head.
JO - IEEE Transactions on Electromagnetic Compatibility
JF - IEEE Transactions on Electromagnetic Compatibility
Y1 - 2006/05//
VL - 48
IS - 2
M3 - Article
SP - 397
EP - 407
SN - 00189375
AB - The specific absorption rates (SAR) determined computationally in the specific anthropomorphic mannequin (SAM) and anatomically correct models of the human head when exposed to a mobile phone model are compared as part of a study organized by IEEE Standards Coordinating Committee 34, Sub-Committee 2, and Working Group 2, and carried out by an international task force comprising 14 government, academic, and industrial research institutions. The detailed study protocol defined the computational head and mobile phone models. The participants used different finite-difference time-domain software and independently positioned the mobile phone and head models in accordance with the protocol. The results show that when the pinna SAR is calculated separately from the head SAR, SAM produced a higher SAR in the head than the anatomically correct head models. Also the larger (adult) head produced a statistically significant higher peak SAR for both the 1- and 10-g averages than did the smaller (child) head for all conditions of frequency and position. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Electromagnetic Compatibility is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL phones
KW - ANTHROPOMORPHISM
KW - FINITE differences
KW - TIME-domain analysis
KW - SIMULATION methods & models
KW - TECHNOLOGICAL innovations
KW - FDTD methods
KW - IEEE standards
KW - phantom
KW - simulation
KW - software standards
KW - specific absorption rate (SAR)
KW - specific anthropomorphic mannequin (SAM)
N1 - Accession Number: 21100741; Beard, Brian B. 1; Email Address: brian.beard@fda.hhs.gov Kainz, Wolfgang 1; Email Address: wolfgang.kainz@fda.hhs.gov Onishi, Teruo 2; Email Address: oonishite@nttdocomo.co.jp Iyama, Takahiro 2; Email Address: iyama@nttdocomo.co.jp Watanabe, Soichi 3; Email Address: wata@nict.go.jp Fujiwara, Osamu 4; Email Address: fujiwara@odin.elcom.nitech.ac.jp Jianqing Wang 4; Email Address: wang@nitech.ac.jp Giorgi Bit-Babik 5; Email Address: goga.bit-babik@motorola.com Faraone, Antonio 5; Email Address: antonio.faraone@motoroIa.com Wiart, Joe 6; Email Address: Joe.wiart@francetelecom.com Christ, Andreas 7; Email Address: christ@itis.ethz.ch Kuster, Niels 7; Email Address: kuster@itis.ethz.ch Ae-Kyoung Lee 8; Email Address: aklee@etri.re.kr Kroeze, Hugo 9; Email Address: H.Kroeze@zu.nl Siegbahn, Martin 10; Email Address: martin.siegbahn@ericsson.com Keshvari, Jafar 11; Email Address: jafar.keshvari@nokia.com Abrishamkar, Houman 12; Email Address: houman@ece.uvic.ca Simon, Winfried 13; Email Address: simon@imst.de Manteuffel, Dirk 13; Email Address: manteuffel@imst.de Nikoloski, Neviana 7; Email Address: neviana@itis.ethz.ch; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20850 USA 2: Wireless Laboratories, NTT DoCoMo, Inc. NTT DoCoMo R&D Center, Kanagawa, 239-836, Japan 3: National Institute of Information and Communications Technology (NICT) Tokyo 184-8795, Japan 4: Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466-855, Japan 5: Motorola Florida Research Laboratories, Corporate EME Research Laboratory, Fort Lauderdale, FL 33322 USA 6: France Telecom FTRD/RESA/FACE/IOP 92794 Issy les Moulineaux, France 7: IT'IS–The Foundation for Research on Information Technologies in Society, Zurich, Switzerland 8: Electronics and Telecommunications Research Institute (ETRI), Daejeon, 305-350 Korea 9: Department of Radiotherapy, University of Utrecht, 3508 GA Utrecht. The Netherlands 10: Ericsson Radio Systems AB S-164 80 Stockholm, Sweden 11: Radio Technologies Laboratory, Nokia Research Center, 00180 Helsinki, Finland 12: Department of Electrical and Computer Engineering, University of Victoria, Victoria, BC V8W 3P6 Canada 13: IMST GmbH, Antennas and EM Modelling 47475 Kamp-Lintfort Germany; Source Info: May2006, Vol. 48 Issue 2, p397; Subject Term: CELL phones; Subject Term: ANTHROPOMORPHISM; Subject Term: FINITE differences; Subject Term: TIME-domain analysis; Subject Term: SIMULATION methods & models; Subject Term: TECHNOLOGICAL innovations; Author-Supplied Keyword: FDTD methods; Author-Supplied Keyword: IEEE standards; Author-Supplied Keyword: phantom; Author-Supplied Keyword: simulation; Author-Supplied Keyword: software standards; Author-Supplied Keyword: specific absorption rate (SAR); Author-Supplied Keyword: specific anthropomorphic mannequin (SAM); NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 443142 Electronics Stores; NAICS/Industry Codes: 517210 Wireless Telecommunications Carriers (except Satellite); NAICS/Industry Codes: 334220 Radio and Television Broadcasting and Wireless Communications Equipment Manufacturing; Number of Pages: 12p; Illustrations: 6 Diagrams, 9 Charts; Document Type: Article
L3 - 10.1109/TEMC.2006.873870
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21100741&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meldrum, R.J.
AU - Smith, R.M.M.
AU - Ellis, P.
AU - Garside, J.
T1 - Microbiological quality of randomly selected ready-to-eat foods sampled between 2003 and 2005 in Wales, UK
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006/05//
VL - 108
IS - 3
M3 - Article
SP - 397
EP - 400
SN - 01681605
AB - Abstract: Since 1995, the publicly funded ready-to-eat food sampling and examination activities in Wales have been coordinated and structured, using a novel approach for the identification of samples and premises. The latest set of data from this surveillance system reports the results from 3391 ready-to-eat foods sampled between November 2003 and March 2005. During this seventeen-month period all samples were examined for aerobic colony count, Escherichia coli, Listeria spp., Bacillus cereus, Salmonella, Staphylococcus aureus and Listeria monocytogenes. The food types with the poorest microbiological quality were cream cakes, custard slices and egg mayonnaise sandwiches. The food type with the best microbiological quality was dried fruit. In conclusion, the results indicate that, in general terms, the ready-to-eat food types sampled and examined in this period posed little bacterial hazard to consumers. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterobacteriaceae
KW - Gram-positive bacteria
KW - Escherichia coli
KW - Staphylococcus aureus infections
KW - Microbiological quality
KW - Ready-to-eat food
KW - Surveillance
N1 - Accession Number: 20398199; Meldrum, R.J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Smith, R.M.M. 2; Ellis, P. 1; Garside, J. 3; Affiliations: 1: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, United Kingdom; 2: Communicable Disease Surveillance Centre Wales, Abton House, Wedal Road, Cardiff, CF4 3QX, United Kingdom; 3: Blaenau Gwent County Borough Council, Civic Centre, Ebbw Vale, NP23 6XB, United Kingdom; Issue Info: May2006, Vol. 108 Issue 3, p397; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Gram-positive bacteria; Thesaurus Term: Escherichia coli; Subject Term: Staphylococcus aureus infections; Author-Supplied Keyword: Microbiological quality; Author-Supplied Keyword: Ready-to-eat food; Author-Supplied Keyword: Surveillance; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2006.01.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Klinman, Dennis M.
T1 - Adjuvant Activity of CpG Oligodeoxynucleotides.
JO - International Reviews of Immunology
JF - International Reviews of Immunology
Y1 - 2006/05//May-Aug2006
VL - 25
IS - 3/4
M3 - Article
SP - 135
EP - 154
PB - Taylor & Francis Ltd
SN - 08830185
AB - Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Th1 and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses by 5- to 500-fold. The CpG motifs present in bacterial DNA plasmids may contribute to the immunogenicity of DNA vaccines. Ongoing clinical studies indicate that CpG ODNs are safe and well tolerated when administered as adjuvants to humans and can improve vaccine-induced immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Reviews of Immunology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTIFICIAL nucleases
KW - OLIGONUCLEOTIDES
KW - B cells
KW - ANTIGEN presenting cells
KW - DENDRITIC cells
KW - CYTOKINES
KW - IMMUNOLOGICAL adjuvants
KW - DNA vaccines
KW - Adjuvant
KW - CpG
KW - innate
KW - oligodeoxynucleotide
KW - Th1
N1 - Accession Number: 22018561; Klinman, Dennis M. 1; Email Address: klinman@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA; Source Info: May-Aug2006, Vol. 25 Issue 3/4, p135; Subject Term: ARTIFICIAL nucleases; Subject Term: OLIGONUCLEOTIDES; Subject Term: B cells; Subject Term: ANTIGEN presenting cells; Subject Term: DENDRITIC cells; Subject Term: CYTOKINES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: DNA vaccines; Author-Supplied Keyword: Adjuvant; Author-Supplied Keyword: CpG; Author-Supplied Keyword: innate; Author-Supplied Keyword: oligodeoxynucleotide; Author-Supplied Keyword: Th1; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 20p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/08830180600743057
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cameron, Lorraine
AU - Lalich, Nina
AU - Bauer, Susan
AU - Booker, Victoria
AU - Bogue, Hilda Ochoa
AU - Samuels, Steven
AU - Steege, Andrea L.
T1 - Occupational Health Survey of Farm Workers by Camp Health Aides.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2006/05//
VL - 12
IS - 2
M3 - Article
SP - 139
EP - 153
SN - 10747583
AB - The article discusses the study done by camp health aides on the magnitude of health problems among migrant farm workers. The study methodology was a community-based cross-sectional survey conducted in Homestead, Florida and Kankakee, Illinois. The survey results showed a high prevalence of health condition consistent due to ergonomic hazards and pesticides exposure. There was a higher prevalence of back pain, eye symptoms, and skin symptoms in Homestead. The back pain was associated to heavy lifting and ladder work while eye and skin symptoms were related to the use of pesticides, fertilizer applications and other agricultural chemicals. However, both respondent places need better adherence to safety standards and greater effort on implementing solutions for health problems is necessary.
KW - Agriculturists
KW - HEALTH
KW - DISEASES
KW - Pesticides
KW - Agricultural chemicals
KW - Spraying & dusting in agriculture
KW - Agriculture
KW - Farmers
KW - Backache
KW - Skin diseases
KW - Eye
KW - Ergonomic exposure
KW - Lay health worker
KW - Migrant farm worker
KW - Occupational health
KW - Surveillance
KW - Traumatic injury
N1 - Accession Number: 20814116; Cameron, Lorraine 1; Lalich, Nina 2,3; Email Address: nina.lalich@case.edu; Bauer, Susan 4; Booker, Victoria 5; Bogue, Hilda Ochoa 6; Samuels, Steven 7; Steege, Andrea L. 1; Affiliations: 1: Epidemiologist, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati Ohio; 2: Assistant Branch Chief, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati Ohio; 3: Case Western Reserve University, MSASS, 10900 Euclid Ave., Cleveland, OH 44106; 4: Executive Director, Community Health Partnership of Illinois, Chicago, Illinois; 5: Associate Director, Migrant Health Promotion, Saline, Michigan; 6: Director, Community Health of South Dade, Inc., Miami, Florida; 7: Associate Adjunct Professor, University of California at Davis, Davis, California; Issue Info: May2006, Vol. 12 Issue 2, p139; Thesaurus Term: Agriculturists; Thesaurus Term: HEALTH; Thesaurus Term: DISEASES; Thesaurus Term: Pesticides; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Spraying & dusting in agriculture; Thesaurus Term: Agriculture; Subject Term: Farmers; Subject Term: Backache; Subject Term: Skin diseases; Subject Term: Eye; Author-Supplied Keyword: Ergonomic exposure; Author-Supplied Keyword: Lay health worker; Author-Supplied Keyword: Migrant farm worker; Author-Supplied Keyword: Occupational health; Author-Supplied Keyword: Surveillance; Author-Supplied Keyword: Traumatic injury; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; Number of Pages: 15p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trucksess, Mary
AU - Weaver, Carol
AU - Oles, Carolyn
AU - D'Ovidio, Kathleen
T1 - Determination of Aflatoxins and Ochratoxin A in Ginseng and Other Botanical Roots by Immunoaffinity Column Cleanup and Liquid Chromatography with Fluorescence Detection.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/05//May/Jun2006
VL - 89
IS - 3
M3 - Article
SP - 624
EP - 630
SN - 10603271
AB - The article describes the determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column (IAC) cleanup and liquid chromatography with fluorescence detection. Aflatoxins and ochratoxin A are mycotoxins that have a broad range of toxic effects such as carcinogenicity, immunotoxicity, neurotoxicity, and reproductive and developmental toxicity. IAC packed with antibodies specific for aflatoxin and ochratoxin A gave recoveries added aflatoxin lower than an IAC for alfatoxin alone.
KW - AFLATOXINS
KW - OCHRATOXINS
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - FLUORESCENCE spectroscopy
N1 - Accession Number: 21141677; Trucksess, Mary 1; Email Address: mary.trucksess@fda.hhs.gov Weaver, Carol 1 Oles, Carolyn 1 D'Ovidio, Kathleen 2; Affiliation: 1: U.S. Food and Drug Administration, 5300 Paint Branch Pkwy, College Park, MD 2: University of Maryland, College Park, MD; Source Info: May/Jun2006, Vol. 89 Issue 3, p624; Subject Term: AFLATOXINS; Subject Term: OCHRATOXINS; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: FLUORESCENCE spectroscopy; Number of Pages: 7p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McClure, Foster D.
AU - Lee, Jung K.
T1 - Determining a One-Tailed Upper Limit for Future Sample Relative Reproducibility Standard Deviations.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/05//May/Jun2006
VL - 89
IS - 3
M3 - Article
SP - 797
EP - 803
SN - 10603271
AB - The article describes a formula for computing an upper limit for future sample relative reproducibility standard deviations obtained using a given method to analyze a given material in a collaborative study. The formula is useful to study directors in the design of collaborative studies because they can use the formula calculations as a barometer for the worst that can be expected with respect to reproducibility precision prior to conducting a study.
KW - STANDARD deviations
KW - GROUP work in research
KW - RESEARCH
KW - METHODOLOGY
KW - ANALYSIS of variance
N1 - Accession Number: 21141694; McClure, Foster D. 1; Email Address: foster.mcclure@cfsan.fda.gov Lee, Jung K. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, Department of Health and Human Services, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: May/Jun2006, Vol. 89 Issue 3, p797; Subject Term: STANDARD deviations; Subject Term: GROUP work in research; Subject Term: RESEARCH; Subject Term: METHODOLOGY; Subject Term: ANALYSIS of variance; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rasooly, Avraham
AU - Herold, Keith E.
T1 - Biosensors for the Analysis of Food- and Waterborne Pathogens and Their Toxins.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/05//May/Jun2006
VL - 89
IS - 3
M3 - Article
SP - 873
EP - 883
SN - 10603271
AB - The article describes biosensors for the analysis of food and waterborne pathogens and their toxins. They provide miniturized systems that can be integrated with online process monitoring systems to analyze samples. The biosensors can be incorporated into various food manufacturing equipment including food processing and packaging systems, dairy tanks, and fermentors. These integrated biosensor chips may allow a complete analysis of the food or dairy product for toxins and pathogens, antibiotics, pesticides, and chemical contaminants, as well as analysis of food and dairy product composition.
KW - FOOD contamination
KW - FOOD -- Analysis
KW - TOXINS
KW - BIOSENSORS
KW - SANITARY chemistry
N1 - Accession Number: 21141706; Rasooly, Avraham 1,2; Email Address: rasoolya@mail.nih.gov Herold, Keith E. 3; Affiliation: 1: National Institutes of Health, National Cancer Institute, Cancer Diagnosis Program, 6130 Executive Blvd, Rockville, MD 20852 2: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biological Sciences, FDA Campus at White Oak, Life Sciences Bldg, 10903 New Hampshire Ave, Silver Spring, MD 20903 3: University of Maryland, Department of Mechanical Engineering, College Park, MD 20742; Source Info: May/Jun2006, Vol. 89 Issue 3, p873; Subject Term: FOOD contamination; Subject Term: FOOD -- Analysis; Subject Term: TOXINS; Subject Term: BIOSENSORS; Subject Term: SANITARY chemistry; Number of Pages: 11p; Illustrations: 1 Diagram, 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donald E. Eggerth
T1 - Modifying the C Index for Use With Holland Codes of Unequal Length.
JO - Journal of Career Assessment
JF - Journal of Career Assessment
Y1 - 2006/05//
VL - 14
IS - 2
M3 - Article
SP - 267
EP - 275
SN - 10690727
AB - The concept of congruence between person and occupation lies at the core of Holland’s (1997) theory of career types. The C index is arguably the best available method for comparing the congruence of two Holland code profiles. The C index reflects the theorized hexagonal structure of the Holland RIASEC model, is sensitive to code ordering, and is simple to calculate. However, the C index is formulated to only make comparisons between Holland code profiles three letters in length. Although this is consistent with the instrumentation and supporting materials developed by Holland and his colleagues, it is inconsistent with both the Strong Interest Inventory (SII) and the Occupational Information Network (O*NET), each of which assigns Holland codes of one to three letters. Consequently, the C index cannot be easily used with either the SII or the O*NET. Moreover, the authors argue that it is arbitrary to always calculate congruence using Holland codes three letters in length and that congruence should only be calculated using those Holland types that are clearly salient in the profiles being compared. The modifications to the C index proposed in this article allow comparisons between Holland code profiles of unequal lengths and/or of less than three letters in length and retain the desirable properties of the original C index: reflection of the hexagonal structure, sensitivity to order, and simplicity of calculation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Career Assessment is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTEREST inventories
KW - STRONG Vocational Interest Blank
KW - VOCATIONAL interests -- Testing
KW - INTELLECTUAL cooperation
N1 - Accession Number: 20494314; Donald E. Eggerth 1; Affiliation: 1: Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, deggerth@cdc.gov. Centers for Disease Control and Prevention National Institute for Occupational Safety and Health; Source Info: May2006, Vol. 14 Issue 2, p267; Subject Term: INTEREST inventories; Subject Term: STRONG Vocational Interest Blank; Subject Term: VOCATIONAL interests -- Testing; Subject Term: INTELLECTUAL cooperation; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donald E. Eggerth
T1 - The Complicated Pig Speaks: A Reply to Gore and Brown and Tinsley.
JO - Journal of Career Assessment
JF - Journal of Career Assessment
Y1 - 2006/05//
VL - 14
IS - 2
M3 - Article
SP - 289
EP - 291
SN - 10690727
AB - Responses are made to comments regarding Eggerth and Andrew (2006) by Gore and Brown (2006) calling for simplification of the modified C index and by Tinsley (2006) questioning the logic of the modified C index (all articles in this issue). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Career Assessment is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDEXES
KW - LOGIC
KW - LETTERS
KW - VOCATIONAL guidance
N1 - Accession Number: 20494317; Donald E. Eggerth 1; Affiliation: 1: Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, deggerth@cdc.gov; Source Info: May2006, Vol. 14 Issue 2, p289; Subject Term: INDEXES; Subject Term: LOGIC; Subject Term: LETTERS; Subject Term: VOCATIONAL guidance; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Ning
AU - Lin, Mei
AU - Fan, Guorong
AU - Hong, Zhanying
AU - Lu, Guocai
T1 - Quantitative determination of MCC-555, a novel insulin sensitizer in beagle dog plasma by high-performance liquid chromatography with fluorescence detection
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/05//
VL - 835
IS - 1/2
M3 - Article
SP - 35
EP - 39
SN - 15700232
AB - Abstract: A sensitive high-performance liquid chromatographic method with fluorescence detection has been developed for determination of MCC-555 (5-[[6-(2-fluorbenzyl)-oxy-2-naphy] methyl]-2,4-thiazolidinedione) in beagle dog plasma. Sample preparation was done by protein precipitation with acetonitrile and a synthetic intermediate of MCC-555 (5-[[6-(2-fluorbenzyl)-oxy-2-naphy] methylene]-2,4-thiazolidinedione) was used as the internal standard (IS). The isocratic mobile phase consisted of acetonitrile–10mmol/l sodium phosphate buffer (pH 4.5) (65:35, v/v) was delivered at a flow rate of 1ml/min to a Kromasil C18 reversed-phase column (250mm×4.6mm, 5μm). The compounds were detected by fluorescence detection, using an excitation wavelength of 232nm, and emission wavelength of 352nm. Calibration curves of MCC-555 were linear in the concentration range of 0.005–2.0μg/ml. Intra- and inter-day precision ranged from 3.4 to 5.4% and 3.0 to 8.8%, respectively. No endogenous interferences were observed with either MCC-555 or IS. The assay is simple, economical, precise, and is directly applicable to pharmacokinetic studies in beagle dogs involving three dose administrations. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN
KW - CHROMATOGRAPHIC analysis
KW - FLUORESCENCE
KW - RADIOACTIVITY
KW - BIOCHEMISTRY
KW - High-performance liquid chromatography
KW - MCC-555
KW - Pharmacokinetics
N1 - Accession Number: 20554472; Sun, Ning 1 Lin, Mei 2 Fan, Guorong 1; Email Address: guorfan@yahoo.com.cn Hong, Zhanying 1 Lu, Guocai 3; Affiliation: 1: Shanghai Key Laboratory for Pharmaceutical Metabolites Research, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, PR China 2: Shanghai Food and Drug Administration, No. 288 South Henan Road, Shanghai, 200010, PR China 3: Center for New Drug Evaluation, Second Military Medical University, No. 800 Xiangyin Road, Shanghai, 200433, PR China; Source Info: May2006, Vol. 835 Issue 1/2, p35; Subject Term: INSULIN; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: FLUORESCENCE; Subject Term: RADIOACTIVITY; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: High-performance liquid chromatography; Author-Supplied Keyword: MCC-555; Author-Supplied Keyword: Pharmacokinetics; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.03.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boudreau, Mary D.
AU - Beland, Frederick A.
T1 - An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2006/05//
VL - 24
IS - 1
M3 - Article
SP - 103
EP - 154
SN - 10590501
AB - Aloe barbadensis (Miller), Aloe vera, has a long history of use as a topical and oral therapeutic. The plant is the source of two products, gel and latex, which are obtained from its fleshy leaves. Aloe vera products contain multiple constituents with potential biological and toxicological activities, yet the active components elude definition. Ingestion of Aloe vera is associated with diarrhea, electrolyte imbalance, kidney dysfunction, and conventional drug interactions; episodes of contact dermatitis, erythema, and phototoxicity have been reported from topical applications. This review examines the botany, physical and chemical properties, and biological activities of the Aloe vera plant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medicinal plants
KW - Useful plants
KW - Alternative medicine
KW - Botany
KW - Toxicology
KW - Aloe vera
KW - Herbal medicine
KW - Therapeutics
KW - Drug interactions
KW - Acemannan
KW - Aloe vera gel
KW - Aloe vera latex
KW - Anthraquinone
KW - Polymannans
KW - Toxicological effects
N1 - Accession Number: 20856114; Boudreau, Mary D. 1; Email Address: mary.boudreau@fda.hhs.gov; Beland, Frederick A. 1; Affiliations: 1: National Center for Toxicological Research, Jefferson, Arkansas, U.S.A.; Issue Info: May2006, Vol. 24 Issue 1, p103; Thesaurus Term: Medicinal plants; Thesaurus Term: Useful plants; Thesaurus Term: Alternative medicine; Thesaurus Term: Botany; Thesaurus Term: Toxicology; Subject Term: Aloe vera; Subject Term: Herbal medicine; Subject Term: Therapeutics; Subject Term: Drug interactions; Author-Supplied Keyword: Acemannan; Author-Supplied Keyword: Aloe vera gel; Author-Supplied Keyword: Aloe vera latex; Author-Supplied Keyword: Anthraquinone; Author-Supplied Keyword: Polymannans; Author-Supplied Keyword: Toxicological effects; Number of Pages: 52p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1080/10590500600614303
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20856114&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WINDSOR, JEFFREY J.
AU - MACFARLANE, LORNA
AU - CLARK, C. GRAHAM
T1 - Internal Transcribed Spacer Dimorphism and Diversity in Dientamoeba fragilis.
JO - Journal of Eukaryotic Microbiology
JF - Journal of Eukaryotic Microbiology
Y1 - 2006/05//May/Jun2006
VL - 53
IS - 3
M3 - Article
SP - 188
EP - 192
SN - 10665234
AB - The internal transcribed spacer (ITS) region of the ribosomal RNA operon is frequently used for detecting sequence variation among closely related species as it is usually homogeneous within strains but evolves more rapidly than ribosomal RNA coding regions. We have studied this region in both genotypes of the human intestinal parasite Dientamoeba fragilis. In contrast to most organisms, we have identified extensive variation between copies of the sequence within the same strain. The ITS occurs in 2 major forms in each genotype but additional heterogeneity is also present within each form. The significance of this finding is unclear, but the only precedent for such variation is in the Apicomplexa, which have multiple dispersed ribosomal RNA operons in contrast to the tandem arrays found in most other eukaryotes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Eukaryotic Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - OPERONS
KW - GENETIC regulation
KW - PARASITES
KW - APICOMPLEXA
KW - Genotype
KW - Histomonas meleagridis
KW - ribosomal RNA
KW - trichomonad
N1 - Accession Number: 20620803; WINDSOR, JEFFREY J. 1 MACFARLANE, LORNA 1 CLARK, C. GRAHAM 2; Email Address: graham.clark@lshtm.ac.uk; Affiliation: 1: National Public Health Service for Wales Aberystwyth, Bronglais Hospital, Aberystwyth, Ceredigion, SY23 1ER, Wales 2: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom; Source Info: May/Jun2006, Vol. 53 Issue 3, p188; Subject Term: RNA; Subject Term: OPERONS; Subject Term: GENETIC regulation; Subject Term: PARASITES; Subject Term: APICOMPLEXA; Author-Supplied Keyword: Genotype; Author-Supplied Keyword: Histomonas meleagridis; Author-Supplied Keyword: ribosomal RNA; Author-Supplied Keyword: trichomonad; Number of Pages: 5p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1111/j.1550-7408.2006.00092.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20620803&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106316965
T1 - From single-parent families to stepfamilies: is the transition associated with adolescent alcohol initiation?
AU - Kirby JB
Y1 - 2006/05//
N1 - Accession Number: 106316965. Language: English. Entry Date: 20060811. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8005417.
KW - Alcohol Drinking -- Evaluation -- In Adolescence
KW - Family Relations
KW - Marital Status
KW - Single Parent
KW - Stepfamilies
KW - Adolescence
KW - Adult
KW - Blacks
KW - Conceptual Framework
KW - Descriptive Statistics
KW - Female
KW - Hispanics
KW - Interviews
KW - Male
KW - Models, Theoretical
KW - Multiple Logistic Regression
KW - Parent-Child Relations
KW - Prospective Studies
KW - Psychological Theory
KW - Religion and Religions
KW - Repeated Measures
KW - Secondary Analysis
KW - Sex Factors
KW - Socioeconomic Factors
KW - Sociological Theory
KW - Students
KW - Surveys
KW - United States
KW - Whites
KW - Human
SP - 685
EP - 711
JO - Journal of Family Issues
JF - Journal of Family Issues
JA - J FAM ISSUES
VL - 27
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - This study addresses two questions: Is stepfamily formation associated with the likelihood that adolescents will initiate alcohol use, and if so, does this association differ by the type of single-parent families from which adolescents move or the type of stepfamilies to which they move? The author found that adolescents who moved to stepfamilies from single-parent families had an elevated risk of initiating alcohol use. A transition from a divorced single-parent family to a stepfamily is associated with an increase in alcohol initiation among boys, but a transition from an unwed single-parent family to a stepfamily is not. In contrast, girls who transition from an unwed single-parent family to a stepfamily show an elevated likelihood of initiating alcohol use, whereas those who transition from divorced single-parent families do not. Adolescents who move to cohabiting stepfamilies do not respond differently than do adolescents who move to married stepfamilies regardless of gender.
SN - 0192-513X
AD - Agency for Healthcare Research and Quality of the Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schlesser, J. E.
AU - Gerdes, R.
AU - Ravishankar, S.
AU - Madsen, K.
AU - Mowbray, J.
AU - A. Y.-l.& Teo
T1 - Survival of a Five-Strain Cocktail of Escherichia coil 0157:H7 during the 60-Day Aging Period of Cheddar Cheese Made from Unpasteurized Milk.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/05//
VL - 69
IS - 5
M3 - Article
SP - 990
EP - 998
SN - 0362028X
AB - The U.S. Food and Drug Administration Standard of Identity for Cheddar cheeses requires pasteurization of the milk, or as an alternative treatment, a minimum 60-day aging at ≥2°C for cheeses made from unpasteurized milk, to reduce the number of viable pathogens that may be present to an acceptable risk. The objective of this study was to investigate the adequacy of the 60-day minimum aging to reduce the numbers of viable pathogens and evaluate milk subpasteurization heat treatment as a process to improve the safety of Cheddar cheeses made from unpasteurized milk. Cheddar cheese was made from unpasteurized milk inoculated with 10¹ to 105 CFU/ml of a five-strain cocktail of acid-tolerant Escherichia coli O157:H7. Samples were collected during the cheese manufacturing process. After pressing, the cheese blocks were packaged into plastic bags, vacuum sealed, and aged at 7°C. After 1 week, the cheese blocks were cut into smaller-size uniform pieces and then vacuum sealed in clear plastic pouches. Samples were plated and enumerated for E. coli O157:H7. Populations of E. coli O157:H7 increased during the cheese-making operations. Population of E. coli O157:H7 in cheese aged for 60 and 120 days at 7°C decreased less than 1 and 2 log, respectively. These studies confirm previous reports that show 60-day aging is inadequate to eliminate E. coli O157:H7 during cheese ripening. Subpasteurization heat-treatment runs were conducted at 148°F (64.4°C) for 17.5 s on milk inoculated with E. coli O157:H7 at 105 CFU/ml. These heat-treatment runs resulted in a 5-log E. coli O157: H7 reduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Pathogenic microorganisms
KW - Cheddar cheese
KW - Raw milk
KW - Pasteurization of milk
KW - Milk -- Heat treatment
N1 - Accession Number: 22212527; Schlesser, J. E. 1; Email Address: Jschless@cfsan.fda.gov; Gerdes, R. 2; Ravishankar, S. 2; Madsen, K. 2; Mowbray, J. 3; A. Y.-l.& Teo 4; Affiliations: 1: National Center for Food Safety and Technology, Food and Drug Administration, Moffeft Campus, Summit-Argo, Illinois 60501; 2: lllinois Institute of Technology, Moffeft Campus, Summit-Argo, Illinois 60501; 3: Food Safety Inspection Service USDA, Washington, D.C. 20050, USA; 4: Cerebos Pacific Limited R&D Division, Singapore 048423; Issue Info: May2006, Vol. 69 Issue 5, p990; Thesaurus Term: Escherichia coli; Thesaurus Term: Pathogenic microorganisms; Subject Term: Cheddar cheese; Subject Term: Raw milk; Subject Term: Pasteurization of milk; Subject Term: Milk -- Heat treatment; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 5 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hines, Cynthia J.
AU - Deddens, James A.
AU - Lu, Chensheng
AU - Fenske, Richard
AU - Striley, Cynthia A. F.
T1 - Mixed-Effect Models for Evaluating Multiple Measures of Atrazine Exposure Among Custom Applicators.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/05//
VL - 3
IS - 5
M3 - Article
SP - 274
EP - 283
PB - Taylor & Francis Ltd
SN - 15459624
AB - The exposure of custom (or commercial) applicators to the herbicide atrazine was measured in environmental (hand wash and dermal patch) and biological (urine and saliva) samples. Surrogate exposure data, such as amount of atrazine sprayed, were also collected. A systematic sampling design was used that included both spray and nonspray days. Fifteen applicators were sampled 5 to 7 days each during a 6-week spring spray season for a total of 89 sampled days. Mixed-effect regression modeling was used to examine the relationship among the surrogate, environmental, and biological atrazine exposure measures. Surrogate measures of atrazine application (either kg of atrazine sprayed or spray atrazine [yes/no]) were significantly associated with increased levels of atrazine or atrazine equivalents (eq) in hand wash, thigh patch, 4-6 p.m. saliva, and 24-hour urine samples. Two days of spraying information (day of sampling and day before sampling) were needed to optimally estimate atrazine biomarkers in the biological samples, whereas only 1 day of spraying information (day of sampling) was needed to estimate atrazine levels in the environmental samples. Thigh and hand atrazine exposures were significantly associated with increased atrazine and atrazine eq. levels in the 4-6 p.m. saliva and 24-hour urine samples, respectively. Levels of 4-6 p.m. salivary atrazine were also significantly associated with increased levels of 24-hour urinary atrazine eq. Atrazine levels in the 4-6 p.m. saliva samples tracked most closely with evening and next morning urinary atrazine eq. Number of days into the study at the time of sample collection predicted urinary and salivary atrazine levels independent of other fixed effects. These results indicate that either surrogate, environmental, or biological exposure measures can be used in appropriately specified models to estimate urinary and salivary atrazine biomarker levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - Pesticides
KW - Bioindicators
KW - Saliva
KW - Biochemistry
KW - atrazine
KW - biological monitoring
KW - immunoassay
KW - mixed-effect models
KW - saliva
KW - urine
N1 - Accession Number: 75127685; Hines, Cynthia J. 1; Deddens, James A. 2; Lu, Chensheng 3; Fenske, Richard 4; Striley, Cynthia A. F. 5; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio,Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio; 3: Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Ohio, Georgia; 4: Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington; 5: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: May2006, Vol. 3 Issue 5, p274; Thesaurus Term: Biochemical markers; Thesaurus Term: Pesticides; Thesaurus Term: Bioindicators; Subject Term: Saliva; Subject Term: Biochemistry; Author-Supplied Keyword: atrazine; Author-Supplied Keyword: biological monitoring; Author-Supplied Keyword: immunoassay; Author-Supplied Keyword: mixed-effect models; Author-Supplied Keyword: saliva; Author-Supplied Keyword: urine; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15459620600637366
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127685&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106459127
T1 - Mixed-effect models for evaluating multiple measures of atrazine exposure among custom applicators.
AU - Hines CJ
AU - Deddens JA
AU - Lu C
AU - Fenske R
AU - Striley CAF
Y1 - 2006/05//
N1 - Accession Number: 106459127. Language: English. Entry Date: 20060623. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D46-7. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by the NIOSH Agricultural Centers Program. NLM UID: 101189458.
KW - Occupational Exposure -- Evaluation
KW - Data Analysis Software
KW - Education, Continuing (Credit)
KW - Enzyme-Linked Immunosorbent Assay
KW - Herbicides -- Adverse Effects
KW - Immunoassay
KW - Regression
KW - Saliva
KW - Urine
KW - Funding Source
KW - Human
SP - 274
EP - 283
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The exposure of custom (or commercial) applicators to the herbicide atrazine was measured in environmental (hand wash and dermal patch) and biological (urine and saliva) samples. Surrogate exposure data, such as amount of atrazine sprayed, were also collected. A systematic sampling design was used that included both spray and nonspray days. Fifteen applicators were sampled 5 to 7 days each during a 6-week spring spray season for a total of 89 sampled days. Mixed-effect regression modeling was used to examine the relationship among the surrogate, environmental, and biological atrazine exposure measures. Surrogate measures of atrazine application (either kg of atrazine sprayed or spray atrazine [yes/no]) were significantly associated with increased levels of atrazine or atrazine equivalents (eq) in hand wash, thigh patch, 4-6 p.m. saliva, and 24-hour urine samples. Two days of spraying information (day of sampling and day before sampling) were needed to optimally estimate atrazine biomarkers in the biological samples, whereas only 1 day of spraying information (day of sampling) was needed to estimate atrazine levels in the environmental samples. Thigh and hand atrazine exposures were significantly associated with increased atrazine and atrazine eq. levels in the 4-6 p.m. saliva and 24-hour urine samples, respectively. Levels of 4-6 p.m. salivary atrazine were also significantly associated with increased levels of 24-hour urinary atrazine eq. Atrazine levels in the 4-6 p.m. saliva samples tracked most closely with evening and next morning urinary atrazine eq. Number of days into the study at the time of sample collection predicted urinary and salivary atrazine levels independent of other fixed effects. These results indicate that either surrogate, environmental, or biological exposure measures can be used in appropriately specified models to estimate urinary and salivary atrazine biomarker levels.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-14, Cincinnati, OH 45226; chines@cdc.gov
U2 - PMID: 16595379.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Myers, Matthew R.
T1 - Tissue deformation induced by radiation force from Gaussian transducers.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2006/05//
VL - 119
IS - 5
M3 - Article
SP - 3147
EP - 3152
SN - 00014966
AB - Imaging techniques based upon the tissue mechanical response to an acoustic radiation force are being actively researched. In this paper a model for predicting steady-state tissue displacement induced by a radiation force arising from the absorption of Gaussian ultrasound beams is presented. A simple analytic expression is derived that agrees closely with the numerical quadrature of the displacement convolution integrals. The analytic result reveals the dependence of the steady-state axial displacement upon the operational parameters, e.g., an inverse proportional relationship to the tissue shear modulus. The derivation requires that the transducer radius be small compared to the focal length, but accurate results were obtained for transducer radii comparable to the focal length. Favorable comparisons with displacement predictions for non-Gaussian transducers indicate that the theory is also useful for a broader range of transducer intensity profiles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACOUSTIC radiation pressure
KW - SOUND pressure
KW - TISSUES
KW - TRANSDUCERS
KW - GAUSSIAN beams
N1 - Accession Number: 20637172; Myers, Matthew R. 1; Affiliation: 1: Center for Devices and Radiological Health, HFZ-170, U. S. Food and Drug Administration, Rockville, Maryland 20852; Source Info: May2006, Vol. 119 Issue 5, p3147; Subject Term: ACOUSTIC radiation pressure; Subject Term: SOUND pressure; Subject Term: TISSUES; Subject Term: TRANSDUCERS; Subject Term: GAUSSIAN beams; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1121/1.2187087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20637172&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Improving Bone Health
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/05//
VL - 106
IS - 5
M3 - Editorial
SP - 651
EP - 651
SN - 00028223
N1 - Accession Number: 20624317; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: May2006, Vol. 106 Issue 5, p651; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2006.03.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106311144
T1 - From the Surgeon General. Improving bone health.
AU - Carmona RH
Y1 - 2006/05//
N1 - Accession Number: 106311144. Language: English. Entry Date: 20060804. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Bone and Bones -- Physiology
KW - Health Promotion
KW - Osteoporosis -- Prevention and Control
KW - Diet
KW - Dietitians
SP - 651
EP - 651
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
U2 - PMID: 16647312.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106311144&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY -
AU - Khan, Agha N.1, akk3@cdc.gov
AU - Griffith, Stanley P.2
AU - Moore, Catherine2
AU - Russell, Dorothy3
AU - Rosario Jr., Arnulfo C.1
AU - Bertolli, Jeanne1
T1 - Standardizing Laboratory Data by Mapping to LOINC.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2006/05//May/Jun2006
Y1 - 2006/05//May/Jun2006
VL - 13
IS - 3
CP - 3
M3 - Article
SP - 353
EP - 355
SN - 10675027
AB - The authors describe a pilot project to standardize local laboratory data at five Indian Health Service (IHS) medical facilities by mapping laboratory test names to Logical Observation Identifier Names and Codes (LOINC). An automated mapping tool was developed to assign LOINC codes. At these sites, they were able to map from 63% to 76% of the local active laboratory tests to LOINC using the mapping tool. Eleven percent to 27% of the tests were mapped manually. They could not assign LOINC codes to 6% to 19% of the laboratory tests due to Incomplete or Incorrect information about these tests. The results achieved approximate other similar efforts. Mapping of laboratory test names to LOINC codes will allow IHS to aggregate laboratory data more easily for disease surveillance and clinical and administrative reporting efforts. This project may provide a model for standardization efforts in other health systems. [ABSTRACT FROM AUTHOR]
KW - Medical informatics
KW - Information storage & retrieval systems -- Medicine
KW - Computers in medicine
KW - Health facilities -- Administration
KW - Communication in medicine
N1 - Accession Number: 20874864; Authors: Khan, Agha N. 1 Email Address: akk3@cdc.gov; Griffith, Stanley P. 2; Moore, Catherine 2; Russell, Dorothy 3; Rosario Jr., Arnulfo C. 1; Bertolli, Jeanne 1; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA; 2: Indian Health Service, Albuquerque, NM; 3: Cimarron Medical Informatics, Tucson, AZ; Subject: Medical informatics; Subject: Information storage & retrieval systems -- Medicine; Subject: Computers in medicine; Subject: Health facilities -- Administration; Subject: Communication in medicine; Number of Pages: 3p; Illustrations: 1 Chart; Record Type: Article
L3 - 10.1197/jamia.M1935
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=20874864&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Lord, Alexandra M.
T1 - Venereal Disease, Hospitals and the Urban Poor: London's "Foul Wards," 1600-1800.
JO - Journal of the History of Sexuality
JF - Journal of the History of Sexuality
Y1 - 2006/05//
VL - 15
IS - 2
M3 - Book Review
SP - 343
EP - 345
PB - University of Texas Press
SN - 10434070
AB - Reviews the book "Venereal Disease, Hospitals and the Urban Poor: London's 'Foul Wards,' 1600-1800," by Kevin P. Siena.
KW - SEXUALLY transmitted diseases
KW - NONFICTION
KW - SIENA, Kevin P.
KW - VENEREAL Disease, Hospitals & the Urban Poor: London's Foul Wards, 1600-1800 (Book)
N1 - Accession Number: 24851619; Lord, Alexandra M. 1; Affiliation: 1: United States Public Health Service; Source Info: May2006, Vol. 15 Issue 2, p343; Subject Term: SEXUALLY transmitted diseases; Subject Term: NONFICTION; Reviews & Products: VENEREAL Disease, Hospitals & the Urban Poor: London's Foul Wards, 1600-1800 (Book); People: SIENA, Kevin P.; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106261066
T1 - Pressure sores -- the problem...This article first appeared in Bedsore Biomechanics and is reproduced by kind permission of Palgrave Macmillan, Macmillan Publishers Ltd
AU - Brand PW
Y1 - 2006/05//2006 May
N1 - Accession Number: 106261066. Language: English. Entry Date: 20070406. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 9306822.
KW - Pressure Ulcer -- Etiology
KW - Animal Studies
KW - Foot -- Innervation
KW - Ischemia -- Etiology
KW - Necrosis -- Etiology
KW - Pressure -- Adverse Effects
KW - Rats
KW - Skin -- Pathology
SP - 9
EP - 11
JO - Journal of Tissue Viability
JF - Journal of Tissue Viability
JA - J TISSUE VIABILITY
VL - 16
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - The problem is that when the surface of the body is denervated, it is liable to break down from a number of widely different mechanical stresses. The obvious common factor of denervation or loss of sensation has allowed many workers to assume that loss of nerves is the most significant element in the aetiology of these pressure sores. Hence, the term 'trophic' ulcer, which suggests that some trophic, or nourishing, element is missing from tissues which are not supported by intact nerves. The nature of this trophic factor is not understood and therefore its influence is difficult to measure and still more difficult to control. We have found that a more fruitful approach to the problem is to concentrate upon the biology and the mechanics of the breakdown of normal surface tissues, and then see if it is very different from the biology and mechanics of the breakdown of denervated tissues.
SN - 0965-206X
AD - Rehabilitation Branch, Department of Health, Education and Welfare, Public Health Service, US Public Health Service Hospital, Carville, LA, USA.
U2 - PMID: 16752707.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106261066&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136309
T1 - Trends in medical care costs, coverage, use, and access: research findings from the Medical Expenditure Panel Survey.
AU - Cohen SB
AU - Buchmueller T
Y1 - 2006/05//
N1 - Accession Number: 106136309. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Health Care Costs -- Trends
KW - Health Services Accessibility -- Economics
KW - Insurance Coverage -- Economics
KW - Insurance, Health -- Economics
KW - United States
SP - I1
EP - 3
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0025-7079
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. scohen@ahrq.gov
U2 - PMID: 16625058.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136309&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136316
T1 - A closer look at the managed care backlash.
AU - Cooper PF
AU - Simon KI
AU - Vistnes J
Y1 - 2006/05//
N1 - Accession Number: 106136316. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Consumer Satisfaction
KW - Health Maintenance Organizations -- Utilization
KW - Insurance, Health
KW - Patient Satisfaction
KW - Business -- Classification
KW - Business -- Economics
KW - Decision Making
KW - Descriptive Statistics
KW - Employment
KW - Fee for Service Plans -- Utilization
KW - Health Services Research
KW - Insurance Coverage
KW - Insurance Selection Bias
KW - Insurance, Health -- Classification
KW - Insurance, Health -- Trends
KW - Managed Care Programs -- Trends
KW - Managed Care Programs -- Utilization
KW - Preferred Provider Organizations -- Utilization
KW - Retrospective Design
KW - United States
KW - Human
SP - I4
EP - 11
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Much anecdotal evidence exists regarding the managed care backlash of the late 1990s, but limited empirical evidence is available. OBJECTIVES: Using a unique series of employer surveys, we examined trends in enrollment rates in health maintenance organizations (HMOs) and other plan types between 1997 and 2003. RESEARCH DESIGN: We present enrollment rates in employer-sponsored health plans by plan type. These plan-level enrollment rates are disaggregated by whether or not enrollees had a choice of plan types and by firm size and year. SUBJECTS: Employees who were enrolled in employer-sponsored health insurance in private sector establishments. RESULTS AND CONCLUSIONS: Although we found evidence of a decline in the popularity of HMOs, it occurred later than indicated in earlier studies. In our data, HMO enrollment rates fell from roughly 32% to 26% between 1997 and 2003, with most of the decline occurring after 2001. Earlier studies reported that the decline in HMO enrollment rates occurred between 1996 and 1998, and between 2000 and 2001. In addition, an interesting story emerged when we examined trends by firm size. We found evidence of a decline in the HMO enrollment rate for large employers starting in 1998. However, this was offset by an increase in the HMO enrollment rate in small employers, which explains the stability in our figures before 2002. Our data also indicated that when workers were given a choice between an HMO and other plan types, workers increasingly opted for the non-HMO plan during this time period.
SN - 0025-7079
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 16625063.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136316&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136310
T1 - Workers who decline employment-related health insurance.
AU - Bernard DM
AU - Selden TM
Y1 - 2006/05//
N1 - Accession Number: 106136310. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Consumer Satisfaction
KW - Family -- Psychosocial Factors
KW - Health Care Costs
KW - Health Services Accessibility
KW - Health Services Needs and Demand
KW - Health Status
KW - Insurance, Health -- Utilization
KW - Medically Uninsured
KW - Adult
KW - Child
KW - Child Health Services
KW - Decision Making
KW - Descriptive Statistics
KW - Eligibility Determination
KW - Insurance Coverage
KW - Middle Age
KW - Poverty
KW - Self Report
KW - Surveys
KW - United States
KW - Human
SP - I12
EP - 8
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Families of workers who decline coverage represent a substantial share of the uninsured and publicly-insured population in the United States. OBJECTIVE: We examined health status, access to health care, utilization, and expenditures among families that declined health insurance coverage offered by employers using data from the Medical Expenditure Panel Survey for 2001 and 2002. RESULTS: We found differences in insurance status for adults and children among families with offers. We found that among low-income families with offers, children are less likely to have private insurance compared with adults. However, the majority of children who decline private insurance end up with public coverage, whereas most of adults who decline offers remain uninsured. Decliners are more likely to report poor health, yet they are also less likely to have high cost medical conditions. Families declining coverage have weaker preferences for insurance than families that take up. Although access to care is lower among the decliners who remain uninsured, decliners with public insurance have similar access to care as those with private insurance. Families turning down coverage are more likely to face high expenditure burdens as a percentage of income and more likely to have financial barriers to care. Families who decline coverage rely heavily on the safety net. Public sources and uncompensated care account for 72% of total expenditures among adults who decline coverage. CONCLUSIONS: Our results suggest that policy initiatives aimed at increasing take up among workers need to take into account the incentives workers face given the availability of care through public sources and uncompensated care.
SN - 0025-7079
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. dbernard@ahrq.gov
U2 - PMID: 16625059.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136310&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136311
T1 - Access to care and utilization among children: estimating the effects of public and private coverage.
AU - Selden TM
AU - Hudson JL
Y1 - 2006/05//
N1 - Accession Number: 106136311. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Child Health Services -- Utilization
KW - Economic and Social Security
KW - Health Services Accessibility -- In Infancy and Childhood
KW - Health Services Needs and Demand -- In Infancy and Childhood
KW - Insurance, Health
KW - Medicaid
KW - Child
KW - Child Health Services -- Economics
KW - Child Welfare
KW - Descriptive Statistics
KW - Economic and Social Security -- Utilization
KW - Health Care Costs
KW - Health Services Research
KW - Insurance, Health -- Utilization
KW - Medicaid -- Utilization
KW - Multivariate Analysis
KW - Private Sector
KW - Public Sector
KW - United States
KW - Univariate Statistics
KW - Human
SP - I19
EP - 26
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: We examine the relationship between health insurance coverage and children's access to and utilization of medical care. Access measures we study are having a usual source of care (USC) and lacking a USC for financial or insurance reasons. We also examine indicators for ambulatory visits, well-child visits, dental visits, emergency room use, and inpatient hospital stays. METHODS: We pool data from the first 7 years of the Medical Expenditure Panel Survey (MEPS), 1996 to 2002. Pooling yields a large sample of children, enabling us to analyze access and utilization using simple descriptive statistics, multivariate analysis, and instrumental variables estimation (IV). IV estimation is of particular interest given the possibility of bias caused by confounding factors (such as child health or parent attitudes) and measurement error in insurance coverage. We also compare estimates from IV linear probability models to estimates from IV probit with residual inclusion. RESULTS: As previous studies have found, public and private coverage are both associated with large increases in access and utilization. Simple mean comparisons suggest that private coverage has a larger effect than does public coverage. Differences between public and private coverage are reduced (and often reversed) when we control for other characteristics of children and their families. IV coverage effect estimates from both linear probability and residual inclusion probit models are substantially greater than conventional estimates across a wide range of access and utilization measures. CONCLUSIONS: Despite concerns that conventional estimates overstate the impact of coverage on access and use, our results suggest that the reverse may be true. One explanation may be that conventional estimates are biased toward zero due to error in the reporting of insurance coverage. The magnitude of the coverage effects we find highlights the importance of reducing uninsurance among children.
SN - 0025-7079
AD - Division of Modeling and Simulation, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. tselden@ahrq.gov
U2 - PMID: 16625060.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136311&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136312
T1 - Trends in prescription drug expenditures by Medicaid enrollees.
AU - Banthin JS
AU - Miller GE
Y1 - 2006/05//
N1 - Accession Number: 106136312. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Drug Utilization
KW - Health Care Costs -- Trends
KW - Medicaid -- Trends
KW - Prescriptions, Drug -- Economics
KW - Adolescence
KW - Adult
KW - Aged
KW - Child
KW - Descriptive Statistics
KW - Disabled
KW - Eligibility Determination
KW - Fees and Charges -- Trends
KW - Health Services Research
KW - Insurance, Pharmaceutical Services -- Economics
KW - Medicaid -- Economics
KW - Medicaid -- Utilization
KW - Middle Age
KW - Prescriptions, Drug -- Classification
KW - State Health Plans -- Economics
KW - United States
KW - Human
SP - I27
EP - 35
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: As prescription drug expenditures consume an increasingly larger portion of Medicaid budgets, states are anxious to control drug costs without endangering enrollees' health. In this report, we analyzed recent trends in Medicaid prescription drug expenditures by therapeutic classes and subclasses. Identifying the fastest growing categories of drugs, where drugs are grouped into clinically relevant classes and subclasses, can help policymakers decide where to focus their cost containment efforts. METHODS: We used data from the Medical Expenditure Panel Survey linked to a prescription drug therapeutic classification system, to examine trends between 1996/1997 and 2001/2002 in utilization and expenditures for the noninstitutionalized Medicaid population. We separated aggregate trends into changes in population with use and changes in expenditures per user, and percent generic. We also highlighted differences within the Medicaid population, including children, adults, disabled, and elderly. RESULTS: We found rapid growth in expenditures for antidepressants, antipsychotics, antihyperlipidemics, antidiabetic agents, antihistamines, COX-2 inhibitors, and proton pump inhibitors and found evidence supporting the rapid take-up of new drugs. In some cases these increases are the result of increased expenditures per user and in other cases the overall growth also comes from an increase in the population with use. CONCLUSIONS: Medicaid programs may want to reassess their cost-containment policies in light of the rapid take-up of new drugs. Our analysis also identifies areas in which more information is needed on the comparative effectiveness of new versus existing treatments.
SN - 0025-7079
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. jbanthin@ahrq.gov
U2 - PMID: 16625061.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136312&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136313
T1 - Children and antibiotics: analysis of reduced use, 1996-2001.
AU - Miller GE
AU - Hudson J
Y1 - 2006/05//
N1 - Accession Number: 106136313. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Antibiotics -- Therapeutic Use -- In Infancy and Childhood
KW - Child Health Services -- Utilization
KW - Drug Utilization -- In Infancy and Childhood
KW - Prescriptions, Drug
KW - Respiratory Tract Infections -- Drug Therapy -- In Infancy and Childhood
KW - Respiratory Tract Infections -- Epidemiology -- In Infancy and Childhood
KW - Adolescence
KW - Ambulatory Care -- Trends
KW - Ambulatory Care -- Utilization
KW - Child
KW - Child Health Services -- Trends
KW - Child, Preschool
KW - Descriptive Statistics
KW - Health Services Research
KW - Infant
KW - Logistic Regression
KW - Office Visits -- Trends
KW - United States
KW - Human
SP - I36
EP - 44
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: We investigated trends in antibiotic use by U.S. children, from 1996 to 2001, a period that followed the launch of national campaigns to promote the appropriate use of antibiotics. DATA AND METHODS: We used nationally representative data from the Medical Expenditure Panel Survey for the years 1996-2001 to examine trends in antibiotic use and the contributions of changes in ambulatory visits and prescribing to these trends. We investigated trends in the use of antibiotics overall and for respiratory tract infections and examined these trends within subgroups of children defined by race/ethnicity and income. RESULTS: From 1996 to 2001, the proportion of children with antibiotic use overall and for respiratory tract infections decreased by 8.5 percentage points and 5.1 percentage points, respectively. Overall, the probability of a child having an ambulatory visit did not change. The decrease in overall antibiotic use resulted entirely from an increase in the probability that a child had an ambulatory visit(s) with no antibiotic use. By contrast, a decline in the probability that a child had a visit for a respiratory tract infection accounted for two-thirds of the reduction in antibiotic use for these conditions. The decline in overall use for white-other non-Hispanic children (-10.2 percentage points) was more than double the decline for black non-Hispanic or Hispanic children. CONCLUSION: Children's use of antibiotics, overall and for respiratory tract infections, showed significant declines from 1996 to 2001. The apparent response to campaigns to reduce inappropriate antibiotic use was widespread as reductions in use were found in all subgroups of children examined.
SN - 0025-7079
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. emiller@ahrq.gov
U2 - PMID: 16625062.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136313&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136314
T1 - The utility of extended longitudinal profiles in predicting future health care expenditures.
AU - Cohen SB
AU - Ezzati-Rice T
AU - Yu W
Y1 - 2006/05//
N1 - Accession Number: 106136314. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Health Care Costs -- Trends
KW - Insurance, Health -- Trends
KW - Models, Statistical
KW - Needs Assessment
KW - Adolescence
KW - Adult
KW - Aged
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Cox Proportional Hazards Model
KW - Descriptive Statistics
KW - Female
KW - Health Services Accessibility -- Economics
KW - Health Services Accessibility -- Trends
KW - Health Services Research
KW - Infant
KW - Infant, Newborn
KW - Insurance, Health -- Economics
KW - Insurance, Health -- Utilization
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Needs Assessment -- Economics
KW - Prospective Studies
KW - United States
KW - Human
SP - I45
EP - 53
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Health care spending is highly concentrated. Prediction models that accurately identify the characteristics of individuals most likely to incur high levels of health expenditures in a subsequent year are important analytical and statistical tools. OBJECTIVES: This study examined the capacity of alternative models to predict the likelihood of incurring high levels of medical expenditures in a subsequent year. This effort also evaluated the utility of an additional year of longitudinal information. SUBJECTS: A nationally representative sample from the Medical Expenditure Panel Survey (MEPS). METHODS: The MEPS longitudinal data are used to examine the persistence of high expenditures during a 2-year period. With the unique linkage of the MEPS to the National Health Interview Survey, the utility of an additional year of data also was examined. Resultant models were evaluated in terms of sensitivity, specificity, and predictive capacity. RESULTS: Only modest marginal gains in discrimination capacity were realized from the use of extended longitudinal profiles from the National Health Interview Survey, relative to information on prior year characteristics. CONCLUSIONS: Our results highlight the continuing concentration of health care expenditures during the period 1996 to 2002 and reveal some attenuation in magnitude in the tail of this distribution over time. Further, our results provide evidence of the utility of probabilistic models as prediction tools to identify individuals likely to incur high levels of expenditures in future years. Predictive capacity does not suffer when restricted to a single year of prior information.
SN - 0025-7079
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. scohen@ahrq.gov
U2 - PMID: 16625064.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136314&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136317
T1 - Using the SF-12 health status measure to improve predictions of medical expenditures.
AU - Fleishman JA
AU - Cohen JW
AU - Manning WG
AU - Kosinski M
Y1 - 2006/05//
N1 - Accession Number: 106136317. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Short Form 12 Health Survey (SF-12). NLM UID: 0230027.
KW - Chronic Disease -- Epidemiology
KW - Health Care Costs -- Trends
KW - Health Status Indicators
KW - Needs Assessment
KW - Adolescence
KW - Adult
KW - Aged
KW - Chi Square Test
KW - Chronic Disease -- Therapy
KW - Demography
KW - Descriptive Statistics
KW - Female
KW - Forecasting
KW - Health Screening -- Economics
KW - Health Screening -- Utilization
KW - Health Services Research
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Outcome Assessment
KW - P-Value
KW - Poisson Distribution
KW - Questionnaires
KW - Reproducibility of Results
KW - Research Instruments
KW - Self Report
KW - United States
KW - Human
SP - I54
EP - 63
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Relatively few studies have used self-reported health status in models to predict medical expenditures, and many of these have used the SF-36. OBJECTIVES: We sought to examine the ability of the briefer SF-12 measure of health status to predict medical expenditures in a nationally representative sample. METHODS: We used data from the 2000-2001 panel of the Medical Expenditure Panel Study. Respondents (n = 5542) completed the SF-12 in a questionnaire. Interviews obtained data on demographics and selected chronic conditions. Data on expenditures incurred subsequent to the interview were obtained in part from provider records. We examined different regression model specifications and compared different statistical estimation techniques. RESULTS: Adding the SF-12 to a regression model improved the prediction of subsequent medical expenditures. In a model with only age and gender, adding the SF-12 increased R from 0.06 to 0.13. The coefficients for the Physical Component Summary (PCS) and the Mental Component Summary (MCS) of the SF-12 for this model were -0.045 (P < 0.01) and -0.012 (P < 0.01), respectively. In a model including demographic characteristics, chronic conditions, and previous expenditures, adding the SF-12 increased the R from 0.26 to 0.29. The coefficients for the PCS and the MCS for this model were -0.025 (P < 0.001) and -0.005 (P = 0.15), respectively. A single general health status question performed almost as well as the full SF-12. Models estimated using ordinary least squares had undesirable properties. In terms of R, a generalized linear model (GLM) with a Poisson variance function was consistently superior to a GLM with a gamma variance function. CONCLUSIONS: Information on self-reported health status is useful in predicting medical expenditures. The extent to which the SF-12 adds predictive power over a comprehensive array of diagnostic data remains to be examined.
SN - 0025-7079
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. jfleishm@ahrq.gov
U2 - PMID: 16625065.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136317&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136318
T1 - Explaining racial and ethnic disparities in health care.
AU - Kirby JB
AU - Taliaferro G
AU - Zuvekas SH
Y1 - 2006/05//
N1 - Accession Number: 106136318. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Attitude to Health -- Ethnology
KW - Blacks
KW - Health Services Accessibility
KW - Health Services Needs and Demand
KW - Hispanics
KW - Patient Attitudes -- Ethnology
KW - Whites
KW - Adult
KW - Aged
KW - Descriptive Statistics
KW - Female
KW - Health Care Costs
KW - Insurance Coverage
KW - Insurance Selection Bias
KW - Insurance, Health
KW - Male
KW - Medically Uninsured
KW - Middle Age
KW - Questionnaires
KW - Race Factors
KW - Regression
KW - United States
KW - Human
SP - I64
EP - 72
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: The substantial racial and ethnic disparities in access to and use of health services are well documented. A number of studies highlight factors such as health insurance coverage and socioeconomic differences that explain some of the differences between groups, but much remains unexplained. We build on this previous research by incorporating additional factors such as attitudes about health care and neighborhood characteristics, as well as separately analyzing different Hispanic subgroups. METHODS: We use the Oaxaca-Blinder regression-based method to decompose differences among racial and ethnic groups in 3 measures related to access, quantifying the portion explained by each of a number of underlying characteristics and the differences that remain unexplained. We use data from the 2000 and 2001 Medical Expenditure Panel Survey (MEPS), a nationally representative survey of the noninstitutionalized U.S. population. We link these data to detailed neighborhood characteristics from the Census Bureau and local provider supply data from the Health Services Resource Administration (HRSA). RESULTS: Consistent with earlier studies, we find insurance status and socioeconomic differences explain a significant part of the disparities. Additionally, neighborhood racial and ethnic composition account for a large portion of disparities in access, and language differences help explain observed disparities in the use-based access measure. However, much of the differences between racial and ethnic groups remain unexplained. We also found substantial variation in the level of disparities among different groups of Hispanics. CONCLUSIONS: Researchers and policymakers may need to broaden the scope of factors they consider as barriers to access if the goal of eliminating disparities in health care is to be achieved.
SN - 0025-7079
AD - Center for Cost, Financing and Access Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. jkirby@ahrq.gov
U2 - PMID: 16625066.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136318&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106136315
T1 - Reports of fewer activity limitations: recovery, survey fatigue, or switching respondent?
AU - Hill SC
AU - Pylypchuk Y
Y1 - 2006/05//
N1 - Accession Number: 106136315. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Activities of Daily Living
KW - Disability Evaluation
KW - Disabled
KW - Rehabilitation
KW - Adult
KW - Descriptive Statistics
KW - Family Characteristics
KW - Female
KW - Functional Status
KW - Health Care Costs
KW - Interviews
KW - Kappa Statistic
KW - Logistic Regression
KW - Male
KW - Needs Assessment
KW - Questionnaires
KW - Recovery
KW - Reproducibility of Results
KW - United States
KW - Human
SP - I73
EP - 81
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Very little is known about the validity and reliability of disability dynamics reported in household surveys, and some researchers argue that measurement error likely plays a large part in reported recovery from disability. OBJECTIVES: We assessed the reliability of reported recovery from activity limitations elicited from 2 types of questions. We assessed competing hypotheses explaining reported recoveries from disability: people are less likely to recover from more severe disabilities, switching between self- and proxy-response affects reported recovery, and survey fatigue reduces reported disability. METHODS: Using the second panel of the Medical Expenditure Panel Survey, we estimated kappas for 2 types of questions in the same interview about limitations in activities of daily living and instrumental activities of daily living. We estimated multinomial logit models of consistently reported recovery, consistently reported ongoing limitations, and inconsistent responses. Recovery is a function of severity, switching respondent, measures of survey burden (such as family size), age, and education. RESULTS: Within an interview, we found substantial reliability for both instrumental activities of daily living and activities of daily living limitations (kappa = 0.62 and 0.70, respectively). Sample members with more severe disabilities are less likely to report recovery, which is consistent with accurate reporting. Controlling for severity, the type of respondent affects reported recovery. Measures of survey burden did not affect reports. CONCLUSION: Researchers can be confident in reports of recovery in the Medical Expenditure Panel Survey, especially when disability status was self-reported in both interviews. Researchers may also want to control for proxy respondents and switching respondents in their analyses.
SN - 0025-7079
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 50850, USA. shill@ahrq.gov
U2 - PMID: 16625067.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136315&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Barror, Richard F.
T1 - USPHS: ENGINEERING FOR LIFE.
JO - Military Engineer
JF - Military Engineer
J1 - Military Engineer
PY - 2006/05//May/Jun2006
Y1 - 2006/05//May/Jun2006
VL - 98
IS - 641
M3 - Article
SP - 89
EP - 91
SN - 00263982
AB - The article discusses on top priority plans of the U.S. Public Health Service (USPHS) for fiscal 2007. It emphasizes that the USPHS is committed to follow its motto “Engineering for Life.” The agency also commissioned several officers that will assist in the recovery efforts for Hurricanes Katrina and Rita in the Gulf Coast. It will also partner with the Federal Emergency Management Agency and National Guard Bureau units to perform various community health services.
KW - PLANNING
KW - UNITED States. Public Health Service
KW - EMERGENCY management
KW - COMMUNITY health services
KW - HURRICANES -- Safety measures
KW - UNITED States. Federal Emergency Management Agency
KW - UNITED States. National Guard Bureau
KW - UNITED States
N1 - Accession Number: 20948645; Source Information: May/Jun2006, Vol. 98 Issue 641, p89; Subject Term: PLANNING; Subject Term: UNITED States. Public Health Service; Subject Term: EMERGENCY management; Subject Term: COMMUNITY health services; Subject Term: HURRICANES -- Safety measures; Subject Term: UNITED States. Federal Emergency Management Agency; Subject Term: UNITED States. National Guard Bureau; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 3p; ; Illustrations: 3 Color Photographs; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Dambach, Megan J.
AU - Trecki, Jordan
AU - Martin, Natalia
AU - Markovitz, Nancy S.
T1 - Oncolytic Viruses Derived from the γ34.5-Deleted Herpes Simplex Virus Recombinant R3616 Encode a Truncated UL3 Protein.
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2006/05//
VL - 13
IS - 5
M3 - Article
SP - 891
EP - 898
SN - 15250016
AB - Replication-competent herpes simplex virus (HSV-1) mutants are used in clinical trials in the experimental treatment of cancer. Mutants G207, HSV1716, NV1020, and Oncovex GM-CSF share in common a defect in one or both copies of the gene encoding the neurovirulence factor, ICP34.5, and are thus neuroattenuated. These viruses are acknowledged to differ from one another (a) in the specific types of mutations intentionally introduced during their derivation and (b) in the inherent genetic differences retained from the different parent strains used in their construction. Unintended mutations are expected to emerge at some low frequency during the selection for and passage of mutant viruses. Here we demonstrate that during the construction of the oncolytic virus R3616, a nonsense mutation arose in an untargeted region of the HSV-1 genome that resulted in a substantial truncation of the viral protein known as UL3. This report is the first published documentation that oncolytic herpesviruses developed and used in clinical trials contain adventitious mutations. The implications of these findings for the characterization and development of vectors proposed for use in clinical trials are discussed.Molecular Therapy (2006) 13, 891–898; doi: 10.1016/j.ymthe.2006.02.006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOGENIC viruses
KW - HERPES simplex virus
KW - HERPESVIRUSES
KW - CANCER treatment
N1 - Accession Number: 25973231; Dambach, Megan J. 1 Trecki, Jordan 1 Martin, Natalia 1 Markovitz, Nancy S. 1; Affiliation: 1: 1Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: May2006, Vol. 13 Issue 5, p891; Subject Term: ONCOGENIC viruses; Subject Term: HERPES simplex virus; Subject Term: HERPESVIRUSES; Subject Term: CANCER treatment; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ymthe.2006.02.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mason, Jeffrey T.
AU - Lixin Xu
AU - Zong-mei Sheng
AU - O'Leary, Timothy J.
T1 - A liposome-PCR assay for the ultrasensitive detection of biological toxins.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/05//
VL - 24
IS - 5
M3 - Article
SP - 555
EP - 557
SN - 10870156
AB - We describe an ultrasensitive immunoassay for detecting biotoxins that uses liposomes with encapsulated DNA reporters, and ganglioside receptors embedded in the bilayer, as a detection reagent. After immobilization of the target biotoxin by a capture antibody and co-binding of the detection reagent, the liposomes are ruptured to release the reporters, which are quantified by real-time PCR. Assays for cholera and botulinum toxins are several orders of magnitude more sensitive than current detection methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunoassay
KW - Liposomes
KW - DNA
KW - Gangliosides
KW - Immunoglobulins
KW - Polymerase chain reaction
N1 - Accession Number: 20736930; Mason, Jeffrey T. 1; Email Address: mason@afip.osd.mil; Lixin Xu 1,2; Zong-mei Sheng 3; O'Leary, Timothy J. 4; Affiliations: 1: Department of Biophysics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, Maryland 20850, USA; 2: Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, US Food and Drug Administration, 29 Lincoln Drive, Bethesda, Maryland 20892, USA; 3: Department of Molecular Pathology, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, Maryland 20850, USA; 4: Biomedical Laboratory Research and Development Service, Veterans Health Administration, 810 Vermont Avenue, NW, Washington, DC 20420, USA; Issue Info: May2006, Vol. 24 Issue 5, p555; Subject Term: Immunoassay; Subject Term: Liposomes; Subject Term: DNA; Subject Term: Gangliosides; Subject Term: Immunoglobulins; Subject Term: Polymerase chain reaction; Number of Pages: 3p; Illustrations: 1 Color Photograph, 1 Graph; Document Type: Article
L3 - 10.1038/nbt1201
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Antonini, James M.
AU - Santamaria, Annette B.
AU - Jenkins, Neil T.
AU - Albini, Elisa
AU - Lucchini, Roberto
T1 - Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2006/05//
VL - 27
IS - 3
M3 - Article
SP - 304
EP - 310
SN - 0161813X
AB - Abstract: Welding fumes are a complex mixture composed of different metals. Most welding fumes contain a small percentage of manganese. There is an emerging concern among occupational health officials about the potential neurological effects associated with the exposure to manganese in welding fumes. Little is known about the fate of manganese that is complexed with other metals in the welding particles after inhalation. Depending on the welding process and the composition of the welding electrode, manganese may be present in different oxidation states and have different solubility properties. These differences may affect the biological responses to manganese after the inhalation of welding fumes. Manganese intoxication and the associated neurological symptoms have been reported in individual cases of welders who have been exposed to high concentrations of manganese-containing welding fumes due to work in poorly ventilated areas. However, the question remains as to whether welders who are exposed to low levels of welding fumes over long periods of time are at risk for the development of neurological diseases. For the most part, questions remain unanswered. There is still paucity of adequate scientific reports on welders who suffered significant neurotoxicity, hence there is a need for well-designed epidemiology studies that combine complete information on the occupational exposure of welders with both behavioral and biochemical endpoints of neurotoxicity. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WELDING fumes
KW - POISONOUS gases
KW - MANGANESE
KW - NEUROTOXICOLOGY
KW - INDUSTRIAL hygiene
KW - Bioavailability
KW - Manganese
KW - Neurotoxicity
KW - Welding fumes
N1 - Accession Number: 20820602; Antonini, James M. 1; Email Address: jga6@cdc.gov Santamaria, Annette B. 2 Jenkins, Neil T. 3 Albini, Elisa 4 Lucchini, Roberto 4; Affiliation: 1: Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road (M/S 2015), Morgantown WV 26505, USA 2: Environ, Houston TX 77099, USA 3: Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge MA 02139, USA 4: Institute of Occupational Health, University of Brescia, 25123 Brescia, Italy; Source Info: May2006, Vol. 27 Issue 3, p304; Subject Term: WELDING fumes; Subject Term: POISONOUS gases; Subject Term: MANGANESE; Subject Term: NEUROTOXICOLOGY; Subject Term: INDUSTRIAL hygiene; Author-Supplied Keyword: Bioavailability; Author-Supplied Keyword: Manganese; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Welding fumes; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuro.2005.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20820602&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nahum, Gerard G.
AU - Uhl, Kathleen
AU - Kennedy, Dianne L.
T1 - Antibiotic Use in Pregnancy and Lactation.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2006/05//
VL - 107
IS - 5
M3 - Article
SP - 1120
EP - 1138
SN - 00297844
AB - The article discusses the risks and pharmacokinetic considerations for broad-spectrum antibiotics that can be used to treat routine and life-threatening infections during pregnancy and lactation. Teratogenic and toxic risk profiles of antibiotics should be considered in making prescribing decisions for pregnant and lactating women. These may become vital if anti-infective agents are needed to protect the people exposed to pathogenic bacteriologic agents that may occur from bioterrorist acts.
KW - ANTIBIOTICS
KW - INFECTION -- Treatment
KW - PREGNANCY complications
KW - LACTATION
KW - PHARMACOKINETICS
KW - ANTI-infective agents
KW - PREGNANT women
KW - PRESCRIPTION of drugs
KW - TREATMENT
N1 - Accession Number: 23404884; Nahum, Gerard G. 1,2; Email Address: GNahum2003@yahoo.com. Uhl, Kathleen 1,2 Kennedy, Dianne L. 1,2; Affiliation: 1: Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Office of Women's Health, US. Food and Drug Administration, Rockville, Maryland 2: FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.; Source Info: May2006, Vol. 107 Issue 5, p1120; Subject Term: ANTIBIOTICS; Subject Term: INFECTION -- Treatment; Subject Term: PREGNANCY complications; Subject Term: LACTATION; Subject Term: PHARMACOKINETICS; Subject Term: ANTI-infective agents; Subject Term: PREGNANT women; Subject Term: PRESCRIPTION of drugs; Subject Term: TREATMENT; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 19p; Illustrations: 13 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fridkin, Scott K.
AU - Kaufman, David
AU - Edwards, Jonathan R.
AU - Shetty, Sharmila
AU - Horan, Teresa
T1 - Changing Incidence of Candida Bloodstream Infections Among NICU Patients in the United States: 1995-2004.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/05//
VL - 117
IS - 5
M3 - Article
SP - 1680
EP - 1687
SN - 00314005
AB - OBJECTIVES. Recent reports suggest that candidemia caused by fluconazole-resistant strains is increasing in certain adult populations. We evaluated the annual incidence of neonatal candidemia and the frequency of disease caused by different species of Candida among neonates in the United States. PATIENTS. The study included neonates admitted to 128 NICUs participating in the National Nosocomial Infections Surveillance system from January 1, 1995, to December 31, 2004 (study period). METHODS. Reports of bloodstream infection (BSI) with Candida spp.; Candida BSIs, patient admissions, patient-days, and central venous catheter days were pooled by birth weight category. The number of Candida BSIs per 100 patients (attack rate) and per 1000 patient-days (incidence density) was determined. Both overall and species-specific rates were calculated; data were pooled over time to determine the differences by birth weight category and by year to determine trends over time. RESULT. From the 130 523 patients admitted to NICUs during the study period, there were 1997 Candida spp. BSIs reported. Overall, 1472 occurred ha the <1000-g birth weight group. Candida albicans BSIs were most common, followed by Candida parapsilosis, Candida tropicalis, Candida lusitaniae, Candida glabrata, and only 3 Candida krusei. Among neonates <1000 g, incidence per 1000 pattern-days decreased from 3.51 during 1995-1999 to 2.68 during 2000-2004 but remained stable among heavier neonates. No increase in infections by species that lend to demonstrate resistance to fluconazole (C glabrata or C krusei) was observed. CONCLUSIONS. Although Candida BSI is a serous problem among neonates < 1000 g, incidence has declined over the past decade, and disease with species commonly resistant to azoles was extremely rare. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANDIDIASIS
KW - MYCOSES
KW - INTENSIVE care units
KW - NOSOCOMIAL infections
KW - IATROGENIC diseases
KW - UNITED States
KW - bloodstream infection
KW - candida
KW - candidiasis
KW - extremely low birth weight infant
KW - fungemia
KW - high-risk nursery
KW - hospital acquired infection
KW - intensive care units
KW - neonatal
N1 - Accession Number: 20811906; Fridkin, Scott K. 1; Email Address: sfridkin@cdc.gov Kaufman, David 2 Edwards, Jonathan R. 3 Shetty, Sharmila 1 Horan, Teresa 4; Affiliation: 1: Mycotic Disease Branch, Division of Bacterial and Mycotic Disease, National Center for Infectious Disease, Center for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 2: Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 3: Health Outcomes Branch, Division of Healthcare Quality Promotion, National Center for Infectious Disease, Center for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 4: Health outcome Branch, Division of Healthcare Quality Promotion, National Center for Infectious Disease, Center for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia; Source Info: May2006, Vol. 117 Issue 5, p1680; Subject Term: CANDIDIASIS; Subject Term: MYCOSES; Subject Term: INTENSIVE care units; Subject Term: NOSOCOMIAL infections; Subject Term: IATROGENIC diseases; Subject Term: UNITED States; Author-Supplied Keyword: bloodstream infection; Author-Supplied Keyword: candida; Author-Supplied Keyword: candidiasis; Author-Supplied Keyword: extremely low birth weight infant; Author-Supplied Keyword: fungemia; Author-Supplied Keyword: high-risk nursery; Author-Supplied Keyword: hospital acquired infection; Author-Supplied Keyword: intensive care units; Author-Supplied Keyword: neonatal; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1542/peds.2005-1996
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20811906&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106317548
T1 - Changing incidence of Candida bloodstream infections among NICU patients in the United States: 1995-2004.
AU - Fridkin SK
AU - Kaufman D
AU - Edwards JR
AU - Shetty S
AU - Horan T
Y1 - 2006/05//
N1 - Accession Number: 106317548. Language: English. Entry Date: 20060811. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Candidiasis -- Epidemiology
KW - Cross Infection -- Epidemiology
KW - Fungemia -- Epidemiology
KW - Antifungal Agents -- Therapeutic Use
KW - Birth Weight
KW - Candidiasis -- Drug Therapy
KW - Chi Square Test
KW - Cross Infection -- Drug Therapy
KW - Data Analysis Software
KW - Incidence
KW - Infant, Newborn
KW - Infant, Very Low Birth Weight
KW - Intensive Care Units, Neonatal
KW - Poisson Distribution
KW - Human
SP - 1680
EP - 1687
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 117
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: Recent reports suggest that candidemia caused by fluconazole-resistant strains is increasing in certain adult populations. We evaluated the annual incidence of neonatal candidemia and the frequency of disease caused by different species of Candida among neonates in the United States. PATIENTS: The study included neonates admitted to 128 NICUs participating in the National Nosocomial Infections Surveillance system from January 1, 1995, to December 31, 2004 (study period). METHODS: Reports of bloodstream infection (BSI) with Candida spp.; Candida BSIs, patient admissions, patient-days, and central venous catheter days were pooled by birth weight category. The number of Candida BSIs per 100 patients (attack rate) and per 1000 patient-days (incidence density) was determined. Both overall and species-specific rates were calculated; data were pooled over time to determine the differences by birth weight category and by year to determine trends over time. RESULTS: From the 130,523 patients admitted to NICUs during the study period, there were 1997 Candida spp. BSIs reported. Overall, 1472 occurred in the < 1000-g birth weight group. Candida albicans BSIs were most common, followed by Candida parapsilosis, Candida tropicalis, Candida lusitaniae, Candida glabrata, and only 3 Candida krusei. Among neonates < 1000 g, incidence per 1000 patient-days decreased from 3.51 during 1995-1999 to 2.68 during 2000-2004 but remained stable among heavier neonates. No increase in infections by species that tend to demonstrate resistance to fluconazole (C glabrata or C krusei) was observed. CONCLUSIONS: Although Candida BSI is a serous problem among neonates < 1000 g, incidence has declined over the past decade, and disease with species commonly resistant to azoles was extremely rare.
SN - 0031-4005
AD - Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia 30333, USA. sfridkin@cdc.gov
U2 - PMID: 16651324.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106317548&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hellinger, Fred J.
T1 - Economic Models of Antiretroviral Therapy: Searching for the Optimal Strategy.
JO - PharmacoEconomics
JF - PharmacoEconomics
Y1 - 2006/05//
VL - 24
IS - 7
M3 - Article
SP - 631
PB - Springer Science & Business Media B.V.
SN - 11707690
AB - The diffusion of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in the US in 1996 and 1997 reduced the number of deaths attributable to HIV disease and changed the way we think about the illness. Today, HIV disease may be deemed a fairly expensive chronic condition rather than an intolerably expensive fatal illness. Although most studies have found that patients receiving new drug therapies are hospitalised less frequently than patients who received early drug therapies, it is unclear whether the diffusion of new drug therapies has increased or decreased the annual cost of care. However, it is evident that the diffusion of new drug therapies has increased the lifetime cost of care. Analysts rely on models to simulate the course and cost of HIV disease. This study reviews the evolution of these models, paying particular attention to how these models estimate the cost of care. The primary findings of this review are that the economic data used in these models are often too imprecise to accurately identify the cost of each disease stage and are almost always outdated. Moreover, it was found that estimates of drug costs in these models may not accurately reflect actual expenditures. [ABSTRACT FROM AUTHOR]
AB - Copyright of PharmacoEconomics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - HIV infections
KW - HIV-positive persons
KW - HEALTH
KW - RESEARCH
KW - THERAPEUTICS
KW - PREVENTIVE medicine
KW - DISEASES -- Social aspects
KW - ECONOMICS -- Statistical methods
N1 - Accession Number: 21806311; Hellinger, Fred J. 1; Email Address: fhelling@ahrq.gov; Affiliation: 1: Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland, USA; Source Info: 2006, Vol. 24 Issue 7, p631; Subject Term: HIV (Viruses); Subject Term: HIV infections; Subject Term: HIV-positive persons; Subject Term: HEALTH; Subject Term: RESEARCH; Subject Term: THERAPEUTICS; Subject Term: PREVENTIVE medicine; Subject Term: DISEASES -- Social aspects; Subject Term: ECONOMICS -- Statistical methods; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiang, Zhengwen
AU - Dragin, Nadine
AU - Jorge-Nebert, Lucia F.
AU - Martin, Martha V.
AU - Peter Guengerich, F.
AU - Aklillu, Eleni
AU - Ingelman-Sundberg, Magnus
AU - Hammons, George J.
AU - Lyn-Cook, Beverly D.
AU - Kadlubar, Fred F.
AU - Saldan~a, Shannon N.
AU - Sorter, Michael
AU - Vinks, Alexander A.
AU - Nassr, Nassr
AU - Von Richter, Oliver
AU - Jin, Li
AU - Nebert, Daniel W.
T1 - Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.
JO - Pharmacogenetics
JF - Pharmacogenetics
Y1 - 2006/05//
VL - 16
IS - 5
M3 - Article
SP - 359
EP - 367
SN - 0960314X
AB - The genotype responsible for more than 60-fold interindividual differences in human hepatic CYP1A2 constitutive expression is not understood. Resequencing the human CYP1A1_CYP1A2 locus (39.6 kb) in five major geographically isolated subgroups recently led to the identification of 85 single nucleotide polymorphisms (SNPs), 57 of which were double-hit SNPs. Here, we attempted to correlate the CYP1A2 genotype with a metabolic phenotype. We chose 16 SNPs (all having a minor allele frequency ≥0.05 in Caucasians) to genotype 32 DNA samples (26 Caucasians, six Ethiopians) in which CYP1A2 metabolism had previously been determined. From 280 subjects (five locations worldwide) that had been CYP1A2-phenotyped, we genotyped the 10 highest, 14 lowest and eight intermediate DNA samples. Although no SNP was significant (P<0.05), possibly due to the small sample size, we found a trend for several of the six SNPs across the CYP1A2 linkage disequilibrium block associated with the trait. Five CYP1A2 haplotypes were inferred, two of which had not previously been reported; haplotype 1A2H10 showed the greatest association with CYP1A2 activity. Regulatory sequences responsible for the large interindividual differences in hepatic CYP1A2 gene basal expression might reside, in part, with some of these CYP1A2 SNPS but, in large part, might be located either cis (in nearby sequences not yet haplotyped) or trans in that they are not linked to the gene. We conclude that no SNP or haplotype in the CYP1A2 gene has yet been identified that can unequivocally be used to predict the metabolic phenotype in any individual patient. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenetics is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - 4-aminobiphenyl N-hydroxylase
KW - 7-ethoxyresorufin O-deethylase
KW - CYP1A2 activity
KW - genotype-phenotype association study
KW - human CYP1A2 gene
KW - urinary caffeine metabolic ratio
N1 - Accession Number: 115111908; Jiang, Zhengwen 1 Dragin, Nadine 1 Jorge-Nebert, Lucia F. 1 Martin, Martha V. 1 Peter Guengerich, F. 1 Aklillu, Eleni 1 Ingelman-Sundberg, Magnus 1 Hammons, George J. 1 Lyn-Cook, Beverly D. 1 Kadlubar, Fred F. 1 Saldan~a, Shannon N. 1 Sorter, Michael 1 Vinks, Alexander A. 1 Nassr, Nassr 1 Von Richter, Oliver 1 Jin, Li 1 Nebert, Daniel W. 1; Affiliation: 1: a Department of Environmental Health and Center for Environmental Genetics (CEG), University of Cincinnati Medical Center, Cincinnati, Ohio, USA b Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA c Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden d Division of Molecular Toxicology, IMM, Karolinska Institutet, Stockholm, Sweden e Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas, USA f Pediatric Pharmacology Research Unit g Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA h Department of Clinical Pharmacology i Division of Drug Metabolism and Pharmacokinetics, ALTANA Pharma AG, Konstanz, Germany; Source Info: May2006, Vol. 16 Issue 5, p359; Author-Supplied Keyword: 4-aminobiphenyl N-hydroxylase; Author-Supplied Keyword: 7-ethoxyresorufin O-deethylase; Author-Supplied Keyword: CYP1A2 activity; Author-Supplied Keyword: genotype-phenotype association study; Author-Supplied Keyword: human CYP1A2 gene; Author-Supplied Keyword: urinary caffeine metabolic ratio; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 8235
L3 - 10.1097/01.fpc.0000204994.99429.46
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ER -
TY - JOUR
AU - Simon, R.
AU - Wang, S.-J.
T1 - Use of genomic signatures in therapeutics development in oncology and other diseases.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/05//
VL - 6
IS - 3
M3 - Article
SP - 166
EP - 173
PB - Nature Publishing Group
SN - 1470269X
AB - Pharmacogenomics is the science of determining how the benefits and adverse effects of a drug vary among a target population of patients based on genomic features of the patient's germ line and diseased tissue. By identifying those patients who are most likely to respond while eliminating serious adverse effects, the therapeutic index of a drug can be substantially increased. This may facilitate demonstrating the effectiveness of the drug and may avoid subsequent problems due to serious adverse events. Our objective here is to provide clinical trial designs and analysis strategies for the utilization of genomic signatures as classifiers for patient stratification or patient selection in therapeutics development. We review methods for the development of genomic signature classifiers of treatment outcome in high-dimensional settings, where the number of variables available for prediction far exceeds the number of cases. The split-sample and crossvalidation methods for obtaining estimates of prediction accuracy in developmental studies are described. We present clinical trial designs for utilizing genomic signature classifiers in therapeutics development. The purpose of the classifier is to facilitate the identification of groups of patients with a high probability of benefiting from it and avoiding serious adverse events. We distinguish exploratory analysis during the development of the genomic classifier from prospective planning and rigorous testing of therapeutic hypotheses in studies that utilize the genomic classifier in therapeutics development. We discuss a variety of clinical trial designs including those utilizing specimen collection and assay prospectively for newly accrued patients and those involving a prospectively planned analysis of archived specimens from a previously conducted clinical trial. Our discussion of the development and use of classifiers of efficacy is mostly focused on applications in oncology using classifiers based on biomarkers measured in tumors. Some of the same considerations apply, however, to development of efficacy and safety classifiers in nononcologic diseases based on single-nucleotide germline polymorphisms.The Pharmacogenomics Journal (2006) 6, 166–173. doi:10.1038/sj.tpj.6500349; published online 17 January 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenomics Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENOMICS
KW - ONCOLOGY
KW - THERAPEUTICS
KW - GENE expression
KW - CLINICAL trials
KW - clinical trial
KW - gene expression
KW - genomic signature
KW - oncology
KW - study design
KW - validation
N1 - Accession Number: 20900451; Simon, R. 1; Email Address: rsimon@nih.gov Wang, S.-J. 2; Affiliation: 1: Biometric Research Branch, Division of Cancer Treatment & Diagnosis, National Cancer Institute, Bethesda, MD, USA 2: Office of Biostatistics, Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation & Research, U.S. Food and Drug Administration, Rockville, MD, USA; Source Info: 2006, Vol. 6 Issue 3, p166; Subject Term: GENOMICS; Subject Term: ONCOLOGY; Subject Term: THERAPEUTICS; Subject Term: GENE expression; Subject Term: CLINICAL trials; Author-Supplied Keyword: clinical trial; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: genomic signature; Author-Supplied Keyword: oncology; Author-Supplied Keyword: study design; Author-Supplied Keyword: validation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1038/sj.tpj.6500349
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106337155
T1 - Commentary: all we are saying is give people with mental illnesses a chance...Davidson L, O'Connell M, Tondora J, et al: The top ten concerns about recovery encountered in mental health system transformation. Psychiatric Services 57:640-5, 2006
AU - Del Vecchio P
Y1 - 2006/05//
N1 - Accession Number: 106337155. Language: English. Entry Date: 20060922. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Attitude of Health Personnel
KW - Mental Disorders -- Rehabilitation
KW - Mental Health Services
KW - Recovery
SP - 646
EP - 646
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 57
IS - 5
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - The Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, Maryland 20857. paolo.delvecchio@samhsa.hhs.gov.
U2 - PMID: 16675757.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anagnoson, J. Theodore1,2, tanagno@calstatela.edu
T1 - Is the Past the Future? The Case of Social Security.
JO - Public Administration Review
JF - Public Administration Review
J1 - Public Administration Review
PY - 2006/05//
Y1 - 2006/05//
VL - 66
IS - 3
CP - 3
M3 - Book Review
SP - 477
EP - 478
SN - 00333352
AB - This article provides reviews of books about Social Security including "The Battle for Social Security: From FDR's Vision to Bush's Gamble," by Nancy J. Altman, and "Robert Ball and the Politics of Social Security," by Edward D. Berkowitz.
KW - Social security
KW - Nonfiction
KW - Berkowitz, Edward D.
KW - Altman, Nancy J.
KW - Battle for Social Security: From FDR's Vision to Bush's Gamble, The (Book)
KW - Robert Ball & the Politics of Social Security (Book)
N1 - Accession Number: 20908063; Authors:Anagnoson, J. Theodore 1,2 Email Address: tanagno@calstatela.edu; Affiliations: 1: Professor of Political Science, California State University, Los Angeles, California; 2: Director of Health Financing Organization, Office of the Assistant Secretary for Planning and Evaluation, United States Department of Health and Human Services (1995-1997); Subject: Battle for Social Security: From FDR's Vision to Bush's Gamble, The (Book); Subject: Robert Ball & the Politics of Social Security (Book); Subject: Berkowitz, Edward D.; Subject: Altman, Nancy J.; Subject: Social security; Subject: Nonfiction; Number of Pages: 2p; Record Type: Book Review
L3 - 10.1111/j.1540-6210.2006.00606.x
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ER -
TY - JOUR
AU - Varricchio, Frederick
AU - Reed, John
T1 - Follow-up Study of Medication Errors Reported to the Vaccine Adverse Event Reporting System (VAERS).
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 2006/05//
VL - 99
IS - 5
M3 - Article
SP - 486
EP - 489
PB - Lippincott Williams & Wilkins
SN - 15418243
AB - Background: A study was done to determine if the apparent medication errors found in the Vaccine Adverse Event Reporting System (VAERS) database are true errors, and if true errors are found, to determine what corrective action was taken. Furthermore, if a true error did not occur, we wanted to determine at what point the misinformation was entered into the system. Methods: The VAERS database was searched for reports received between July 1, 2001 and June 30, 2002 which had either been classified as "error" or the word "error" appeared in the text of the report. The database was also searched for reports which indicated that the measles-mumps-rubella (MMR), diphtheria-tetanus-pertussis (DTP), diphtheria-tetanus-acellular pertussis (DTaP) or diphtheria-tetanus-pertussis-haemophilus (DTPH) vaccinations had been ad- ministered at an age outside of the usual recommendation. Results: A total of 119 reports of possible errors were found. Follow-up was successful in 102 (86%) cases. Additional information obtained showed that 26 cases were actual medication errors. Seventy-six cases were not actual medication errors; 9 cases were physician decisions, 37 cases were data entry errors and 30 cases were reporter errors. Conclusion: The nature of the actual errors was similar to those reported previously; wrong inoculum, improper interval, wrong route of administration, and overdose. Many errors could have been prevented by more attention to detail. Remedial action usually consisted of retraining. The new requirement that all medications be bar-coded, purchasing products from different manufacturers and segregation of vials may help prevent vial confusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Southern Medical Journal is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICATION errors
KW - VACCINATION
KW - DATABASES
KW - MEDICAL records
KW - VACCINES
KW - MEDICAL errors
KW - medication error
KW - surveillance
KW - vaccine
N1 - Accession Number: 21081498; Varricchio, Frederick 1; Email Address: Varricchio@comcast.net Reed, John 1; Affiliation: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville MD.; Source Info: May2006, Vol. 99 Issue 5, p486; Subject Term: MEDICATION errors; Subject Term: VACCINATION; Subject Term: DATABASES; Subject Term: MEDICAL records; Subject Term: VACCINES; Subject Term: MEDICAL errors; Author-Supplied Keyword: medication error; Author-Supplied Keyword: surveillance; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Holsapple, Michael P.
AU - Jones, David
AU - Kawabata, Thomas T.
AU - Kimber, Ian
AU - Sarlo, Kathy
AU - Selgrade, MaryJane K.
AU - Jui Shah
AU - Woolhiser, Michael R.
T1 - Assessing the Potential to Induce Respiratory Hypersensitivity.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/05//
VL - 91
IS - 1
M3 - Article
SP - 4
EP - 13
PB - Oxford University Press / USA
SN - 10966080
AB - Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for many years. It is known that damage to the respiratory tract can be triggered either by nonspecific irritation or by specific immune-mediated pathogenesis, and it is acknowledged that traditional inhalation studies are not designed to address fully the impact of the latter. It is also recognized that different types of immune-mediated responses can be triggered by different classes of compounds and that some immune reactions in the lung are life threatening. As such, it is important to understand as fully as possible the basis for the immune-mediated damage to the lung in order to characterize adequately the risks of individual chemicals or proteins. It is against this background that a review of the methods used to assess the potential for immune-mediated respiratory hypersensitivity was conducted. The primary objectives of this review are to discuss appropriate methods for identifying and characterizing respiratory hypersensitivity hazards and risks; and to identify key data gaps and related research needs with respect to respiratory hypersensitivity testing. The following working definition of respiratory hypersensitivity was formulated: a hypersensitivity response in the respiratory tract precipitated by a specific immune response, mediated by multiple mechanisms, including IgE antibody. Because of the importance played by various classes of compounds, the subsequent sections of this review will consider protein-specific, chemical-specific, and drug-specific aspects of respiratory hypersensitivity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Allergy
KW - Immune response
KW - Immunoglobulin E
KW - Proteins
KW - immunotoxicology—chemical allergy
KW - immunotoxicology—protein allergy
KW - immunotoxicology--chemical allergy
KW - immunotoxicology--protein allergy
KW - respiratory toxicology—respiratory sensitization
KW - respiratory toxicology--respiratory sensitization
N1 - Accession Number: 44406528; Holsapple, Michael P. 1; Email Address: mholsapple@ilsi.org; Jones, David 2; Kawabata, Thomas T. 3; Kimber, Ian 4; Sarlo, Kathy 5; Selgrade, MaryJane K. 6; Jui Shah 7; Woolhiser, Michael R. 8; Affiliations: 1: ILSI Health and Environmental Sciences Institute, Washington, DC; 2: UK Medicines and Healthcare Products Regulatory Agency, London, U.K.; 3: Pfizer, Inc., Groton, Connecticut; 4: Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, U.K.; 5: The Procter & Gamble Company, Cincinnati, Ohio; 6: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; 7: U.S. Food and Drug Administration, Rockville, Maryland; 8: The Dow Chemical Company, Midland, Michigan; Issue Info: May2006, Vol. 91 Issue 1, p4; Thesaurus Term: Toxicology; Thesaurus Term: Allergy; Thesaurus Term: Immune response; Subject Term: Immunoglobulin E; Subject Term: Proteins; Author-Supplied Keyword: immunotoxicology—chemical allergy; Author-Supplied Keyword: immunotoxicology—protein allergy; Author-Supplied Keyword: immunotoxicology--chemical allergy; Author-Supplied Keyword: immunotoxicology--protein allergy; Author-Supplied Keyword: respiratory toxicology—respiratory sensitization; Author-Supplied Keyword: respiratory toxicology--respiratory sensitization; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1093/toxsci/kfj074
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ER -
TY - JOUR
AU - Thomas, Treye
AU - Thomas, Karluss
AU - Sadrieh, Nakissa
AU - Savage, Nora
AU - Adair, Patricia
AU - Bronaugh, Robert
T1 - Research Strategies for Safety Evaluation of Nanomaterials, Part VII: Evaluating Consumer Exposure to Nanoscale Materials.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/05//
VL - 91
IS - 1
M3 - Article
SP - 14
EP - 19
PB - Oxford University Press / USA
SN - 10966080
AB - Considerable media attention has recently been given to novel applications for products that contain nanoscale materials. These products could have utility in several industries that market consumer products, including textiles, sporting equipment, cosmetics, consumer electronics, and household cleaners. Some of the purported benefits of these products include improved performance, convenience, lower cost, as well as other desirable features, when compared to the conventional products that do not contain nanoscale materials. Although there are numerous likely consumer advantages from products containing nanoscale materials, there is very little information available regarding consumer exposure to the nanoscale materials in these products or any associated risks from these exposures. This paper seeks to review a limited subset of products that contain nanoscale materials, assess the available data for evaluating the consumer exposures and potential hazards associated with these products, and discuss the capacity of U.S. regulatory agencies to address the potential risks associated with these products. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nanostructured materials
KW - Commercial products
KW - Product safety
KW - Government agencies -- United States
KW - United States
KW - consumer products
KW - exposure assessment
KW - nanoscale materials
KW - product safety
KW - regulatory agencies
N1 - Accession Number: 44406542; Thomas, Treye 1; Email Address: tthomas@cpsc.gov; Thomas, Karluss 2; Sadrieh, Nakissa 3; Savage, Nora 4; Adair, Patricia 1; Bronaugh, Robert 5; Affiliations: 1: U.S. Consumer Product Safety Commission, Bethesda, Maryland 20814; 2: ILSI Health and Environmental Sciences Institute, Washington, District of Columbia 20005; 3: U.S. Food and Drug Administration, Rockville, Maryland 20852; 4: U.S. Environmental Protection Agency, Washington, District of Columbia 20460; 5: U.S. Food and Drug Administration, Laurel, Maryland 20708; Issue Info: May2006, Vol. 91 Issue 1, p14; Subject Term: Nanostructured materials; Subject Term: Commercial products; Subject Term: Product safety; Subject Term: Government agencies -- United States; Subject: United States; Author-Supplied Keyword: consumer products; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: nanoscale materials; Author-Supplied Keyword: product safety; Author-Supplied Keyword: regulatory agencies; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; Number of Pages: 6p; Document Type: Article
L3 - 10.1093/toxsci/kfj129
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DB - eih
ER -
TY - JOUR
AU - Cheng Wang
AU - Sadovova, Natalya
AU - Hotchkiss, Charlotte
AU - Xin Fu
AU - Scallet, Andrew C.
AU - Patterson, Tucker A.
AU - Hanig, Joseph
AU - Paule, Merle G.
AU - Slikker Jr., William
T1 - Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/05//
VL - 91
IS - 1
M3 - Article
SP - 192
EP - 201
PB - Oxford University Press / USA
SN - 10966080
AB - Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is used as a general pediatric anesthetic. Recent data suggest that anesthetic drugs may cause neurodegeneration during development. The purpose of this study was to determine the robustness of ketamine-induced developmental neurotoxicity using rhesus monkey frontal cortical cultures and also to determine if dysregulation of NMDA receptor subunits promotes ketamine-induced cell death. Frontal cortical cells collected from the neonatal monkey were incubated for 24 h with 1, 10, or 20μM ketamine alone or with ketamine plus either NR1 antisense oligonucleotides or the nuclear factor kB translocation inhibitor, SN-50. Ketamine caused a marked reduction in the neuronal marker polysialic acid neural cell adhesion molecule and mitochondrial metabolism, as well as an increase in DNA fragmentation and release of lactate dehydrogenase. Ketamine-induced effects were blocked by NR1 antisenses and SN-50. These data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drug receptors
KW - Methyl aspartate
KW - Ketamine
KW - NF-kappa B (DNA-binding protein)
KW - Neurons
KW - antisense oligonucleotide
KW - in vitro
KW - ketamine
KW - neonatal rhesus monkey
KW - neurodegeneration
KW - NMDA receptor
N1 - Accession Number: 44406556; Cheng Wang 1; Sadovova, Natalya 2; Hotchkiss, Charlotte 3; Xin Fu 4; Scallet, Andrew C. 1; Patterson, Tucker A. 1; Hanig, Joseph 5; Paule, Merle G. 1; Slikker Jr., William 1; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas; 2: Toxicologic Pathology Associates, Jefferson, Arkansas; 3: The Bionetics Corporation, Jefferson, Arkansas; 4: Division of Biochemical Toxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas; 5: Center for Drug Evaluation and Research/Food and Drug Administration, Rockville, Maryland; Issue Info: May2006, Vol. 91 Issue 1, p192; Thesaurus Term: Drug receptors; Subject Term: Methyl aspartate; Subject Term: Ketamine; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: Neurons; Author-Supplied Keyword: antisense oligonucleotide; Author-Supplied Keyword: in vitro; Author-Supplied Keyword: ketamine; Author-Supplied Keyword: neonatal rhesus monkey; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: NMDA receptor; Number of Pages: 10p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfj144
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DB - eih
ER -
TY - JOUR
AU - Qingsu Xia
AU - Chou, Ming W.
AU - Yin, Jun J.
AU - Howard, Paul C.
AU - Hongtao Yu
AU - Fu, Peter P.
T1 - Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2006/05//
VL - 22
IS - 4
M3 - Article
SP - 147
EP - 156
PB - Sage Publications, Ltd.
SN - 07482337
AB - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Pollutants
KW - Carcinogenicity
KW - Peroxidation
KW - Superoxide dismutase
KW - Deuterium oxide
KW - Linoleic acid
KW - Active oxygen
KW - Superoxides
KW - lipid peroxidation
KW - PAHs
KW - PHOTOIRRADIATION
KW - UVA LIGHT
N1 - Accession Number: 20561672; Qingsu Xia 1; Chou, Ming W. 1; Yin, Jun J. 2; Howard, Paul C. 1; Hongtao Yu 3; Email Address: yu@ccaix.jsums.edu; Fu, Peter P. 1; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; 2: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; 3: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA; Issue Info: 2006, Vol. 22 Issue 4, p147; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Pollutants; Thesaurus Term: Carcinogenicity; Subject Term: Peroxidation; Subject Term: Superoxide dismutase; Subject Term: Deuterium oxide; Subject Term: Linoleic acid; Subject Term: Active oxygen; Subject Term: Superoxides; Author-Supplied Keyword: lipid peroxidation; Author-Supplied Keyword: PAHs; Author-Supplied Keyword: PHOTOIRRADIATION; Author-Supplied Keyword: UVA LIGHT; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1191/0748233706th259oa
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DB - eih
ER -
TY - JOUR
AU - Jian Yan
AU - Wamer, Wayne G.
AU - Howard, Paul C.
AU - Boudreau, Mary D.
AU - Fu, Peter P.
T1 - Levels of retinyl palmitate and retinol in the stratum corneum, epidermis, and dermis of female SKH-1 mice topically treated with retinyl palmitate.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2006/05//
VL - 22
IS - 4
M3 - Article
SP - 181
EP - 191
PB - Sage Publications, Ltd.
SN - 07482337
AB - Retinyl esters are the storage form of vitamin A in skin, and retinyl palmitate (RP) accounts for the majority of the retinyl esters endogenously formed in skin. RP is also obtained exogenously through the topical application of cosmetic and skin care products that contain RP. There is limited information on the penetration and distribution of RP and vitamin A within the stratified layers of the skin. The purpose of these studies was to determine the time course for accumulation and disappearance of RP and retinol in the stratified layers of skin from female SKH-1 mice that received single or repeated topical applications of creams containing 0.5 or 2% of RP. We developed an HPLC method with detection limits of 5.94 and 1.62 ng, to simultaneously quantify the amount of RP and retinol, respectively, in skin samples. Our results showed that RP rapidly diffuses into the stratum corneum and epidermal skin layers within 24 h following the application of RP-containing creams. Of the three skin layers, the highest level of RP and retinol per weight unit (ng/mg) at all time points was found in the epidermis. Levels of RP and retinol were lowest in the dermal layer and intermediate in the stratum corneum. The levels of RP and retinol in the separated skin layers and in the intact skin decreased with time, but levels of RP remained higher than control values for a period of up to 18 days. Our results indicate that the application of RP to mouse skin alters the normal physiological levels of RP and retinol in the skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Research
KW - Mice
KW - Skin
KW - Retinoids
KW - Esters
KW - Vitamin A
KW - Epidermis
KW - Dermis
KW - Cosmetics
KW - MOUSE SKIN
KW - Mouse skin; retinol; retinyl palmitate
KW - RETINOL
KW - RETINYL PALMITATE
N1 - Accession Number: 20561668; Jian Yan 1; Wamer, Wayne G. 2; Howard, Paul C. 1; Boudreau, Mary D. 1; Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; 2: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Issue Info: 2006, Vol. 22 Issue 4, p181; Thesaurus Term: Research; Thesaurus Term: Mice; Subject Term: Skin; Subject Term: Retinoids; Subject Term: Esters; Subject Term: Vitamin A; Subject Term: Epidermis; Subject Term: Dermis; Subject Term: Cosmetics; Author-Supplied Keyword: MOUSE SKIN; Author-Supplied Keyword: Mouse skin; retinol; retinyl palmitate; Author-Supplied Keyword: RETINOL; Author-Supplied Keyword: RETINYL PALMITATE; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1191/0748233706th253oa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20561668&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Marszal, Ewa
AU - Shrake, Andrew
T1 - Characterization of differences in isoelectric focusing behavior of α1-proteinase inhibitor products.
JO - Transfusion
JF - Transfusion
Y1 - 2006/05//
VL - 46
IS - 5
M3 - Letter
SP - 872
EP - 873
PB - Wiley-Blackwell
SN - 00411132
AB - A letter to the editor is presented that discusses topics about the isolelectric focusing behavior of proteinase inhibitor products in several issues.
KW - LETTERS to the editor
KW - PROTEINASES
KW - THERAPEUTIC use
N1 - Accession Number: 20583185; Marszal, Ewa; Email Address: ewa.marszal@fda.hhs.gov Shrake, Andrew 1; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; Source Info: May2006, Vol. 46 Issue 5, p872; Subject Term: LETTERS to the editor; Subject Term: PROTEINASES; Subject Term: THERAPEUTIC use; Number of Pages: 2p; Illustrations: 1 Diagram; Document Type: Letter
L3 - 10.1111/j.1537-2995.2006.00809.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20583185&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mertens, Paul L. J. M.
AU - Widdowson, Marc-Alain
AU - van der Avoort, Harrie G. A. M.
AU - Richardus, Jan Hendrik
T1 - Risk of introduction of poliovirus into a Dutch Cape Verdian community during an outbreak of poliovirus in Cape Verde, 2000.
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
Y1 - 2006/05//
VL - 11
IS - 5
M3 - Article
SP - 746
EP - 750
PB - Wiley-Blackwell
SN - 13602276
AB - Objective To assess the risk of introduction of polio virus in a Cape Verdian community of Rotterdam, during the polio epidemic in Cape Verde in 2000. Methods All 225 insufficiently vaccinated 0–14-year-old Cape Verdian children ( n = 4188) and a random sample of 285 out of all 15–30-year-old Cape Verdians ( n = 5074) in Rotterdam were surveyed to assess travel behaviour and vaccination coverage. Faecal specimens were collected and sewage samples taken in neighbourhoods with a sizable Cape Verdian population for testing of polio virus. Results During the polio epidemic in Cape Verde, 10% of insufficiently vaccinated children aged 0–14 years and 17% of adults aged 15–30 years living in Rotterdam reported travelling to Cape Verde. 94.6% of Cape Verdians in Rotterdam aged 0–14 years were sufficiently vaccinated against polio, but 9 of 91 insufficiently vaccinated children had travelled to Cape Verde during the epidemic. Of those aged 15–30 years, 10% were not vaccinated against polio. In the faeces of 80 insufficiently vaccinated individuals aged 0–14 years and in 74 adults aged 15–30 years, no poliovirus was detected. Samples of sewage from six sites were negative for poliovirus. Conclusion No evidence of poliovirus infection was found in the Cape Verde population in Rotterdam despite extensive travel to the Cape Verde during the outbreak. [ABSTRACT FROM AUTHOR]
AB - Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIO
KW - SURVEYS
KW - VACCINATION
KW - IMMUNIZATION of children
KW - EPIDEMICS
KW - POLIOVIRUS
KW - ROTTERDAM (Netherlands)
KW - NETHERLANDS
KW - Cape Verde
KW - poliomyelitis
KW - poliovirus
KW - religion
KW - vaccination
N1 - Accession Number: 20583222; Mertens, Paul L. J. M. 1,2; Email Address: paul.mertens@wxs.nl Widdowson, Marc-Alain 3 van der Avoort, Harrie G. A. M. 4 Richardus, Jan Hendrik 1,2; Affiliation: 1: Municipal Public Health Service, Rotterdam, The Netherlands 2: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 3: Centers for Disease Control and Prevention, Atlanta, GA, USA 4: National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Source Info: May2006, Vol. 11 Issue 5, p746; Subject Term: POLIO; Subject Term: SURVEYS; Subject Term: VACCINATION; Subject Term: IMMUNIZATION of children; Subject Term: EPIDEMICS; Subject Term: POLIOVIRUS; Subject Term: ROTTERDAM (Netherlands); Subject Term: NETHERLANDS; Author-Supplied Keyword: Cape Verde; Author-Supplied Keyword: poliomyelitis; Author-Supplied Keyword: poliovirus; Author-Supplied Keyword: religion; Author-Supplied Keyword: vaccination; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1365-3156.2006.01611.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20583222&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hirschhorn, Lisa R.
AU - McInnes, Keith
AU - Landon, Bruce E.
AU - Wilson, Ira B.
AU - Ding, Lin
AU - Marsden, Peter V.
AU - Malitz, Faye
AU - Cleary, Paul D.
T1 - Gender differences in quality of HIV care in Ryan White CARE Act-funded clinics
JO - Women's Health Issues
JF - Women's Health Issues
Y1 - 2006/05//
VL - 16
IS - 3
M3 - Article
SP - 104
EP - 112
SN - 10493867
AB - Background: Women with HIV infection have lagged behind men in receipt of critical health care, but it is not known if those disparities are due in part to where women receive care. We examined differences in care received by HIV-infected women and men in a national sample of Ryan White CARE Act–funded clinics and explored the influence of clinic characteristics on care quality. Methods: Record review was done on a sample of 9,015 patients who received care at 69 CARE Act–funded HIV primary care clinics that participated in a quality improvement study. Outcome measures studied were highly active antiretroviral therapy (HAART) use, HIV viral suppression, Pneumocystis jiroveci pneumonia (PCP) prophylaxis, screening, and other disease prevention efforts. Results: Women were less likely than men to receive HAART (78% versus 82%, p < .001), receive PCP prophylaxis (65% versus 75%, p < .0001), or have their hepatitis C virus status known (87% versus 88%, p = .02) despite being seen more regularly (69% versus 66%, p = .04). Sites serving high percentages of women delivered similar or better care for both men and women than other sites. Although sites serving a higher percent of women had more support services such as case management and onsite obstetrician–gynecologists and provided Pap smears at higher rates, women at such sites remained less likely than men to receive important HIV care including HAART and PCP prophylaxis. Conclusions: The gap in the quality of care provided to HIV-infected men and women in critical areas persists, and is not explained by the types of sites where men and women receive care. [Copyright &y& Elsevier]
AB - Copyright of Women's Health Issues is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - PATIENTS
KW - ANTIRETROVIRAL agents
KW - PNEUMONIA
KW - HIV
KW - Quality of care
KW - Ryan White CARE Act
KW - Women
N1 - Accession Number: 21263668; Hirschhorn, Lisa R. 1; Email Address: LRH3@HMS.Harvard.edu McInnes, Keith 2 Landon, Bruce E. 2 Wilson, Ira B. 3 Ding, Lin 2 Marsden, Peter V. 4 Malitz, Faye 5 Cleary, Paul D. 2; Affiliation: 1: Harvard Medical School Division of AIDS, Harvard Medical School, Boston, Massachusetts 2: Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 3: Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts 4: Department of Sociology, Harvard University, Cambridge, Massachusetts 5: Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Maryland; Source Info: May2006, Vol. 16 Issue 3, p104; Subject Term: HIV infections; Subject Term: PATIENTS; Subject Term: ANTIRETROVIRAL agents; Subject Term: PNEUMONIA; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Quality of care; Author-Supplied Keyword: Ryan White CARE Act; Author-Supplied Keyword: Women; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.whi.2006.02.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21263668&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-04443-006
AN - 2006-04443-006
AU - Eggerth, Donald E.
AU - Andrew, Michael E.
T1 - Modifying the C Index for Use With Holland Codes of Unequal Length.
JF - Journal of Career Assessment
JO - Journal of Career Assessment
JA - J Career Assess
Y1 - 2006/05//
VL - 14
IS - 2
SP - 267
EP - 275
CY - US
PB - Sage Publications
SN - 1069-0727
SN - 1552-4590
AD - Eggerth, Donald E., Training Research and Evaluation Branch, CDC/NIOSH, 4676 Columbia Parkway, C-10, Cincinnati, OH, US, 45226
N1 - Accession Number: 2006-04443-006. Partial author list: First Author & Affiliation: Eggerth, Donald E.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20060417. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Occupational Choice; Occupational Interests; Profiles (Measurement). Minor Descriptor: Occupational Interest Measures; Person Environment Fit; Self-Congruence. Classification: Occupational & Employment Testing (2228); Occupational Interests & Guidance (3610). Population: Human (10). Tests & Measures: C Index. Methodology: Empirical Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2006.
AB - The concept of congruence between person and occupation lies at the core of Holland's (1997) theory of career types. The C index is arguably the best available method for comparing the congruence of two Holland code profiles. The C index reflects the theorized hexagonal structure of the Holland RIASEC model, is sensitive to code ordering, and is simple to calculate. However, the C index is formulated to only make comparisons between Holland code profiles three letters in length. Although this is consistent with the instrumentation and supporting materials developed by Holland and his colleagues, it is inconsistent with both the Strong Interest Inventory (SII) and the Occupational Information Network (ONET), each of which assigns Holland codes of one to three letters. Consequently, the C index cannot be easily used with either the SII or the ONET. Moreover, the authors argue that it is arbitrary to always calculate congruence using Holland codes three letters in length and that congruence should only be calculated using those Holland types that are clearly salient in the profiles being compared. The modifications to the C index proposed in this article allow comparisons between Holland code profiles of unequal lengths and/or of less than three letters in length and retain the desirable properties of the original C index: reflection of the hexagonal structure, sensitivity to order, and simplicity of calculation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - C Index modifications
KW - unequal length Holland Codes
KW - Holland's theory
KW - career types
KW - person-occupation congruence
KW - Holland types
KW - 2006
KW - Occupational Choice
KW - Occupational Interests
KW - Profiles (Measurement)
KW - Occupational Interest Measures
KW - Person Environment Fit
KW - Self-Congruence
KW - 2006
DO - 10.1177/1069072705283976
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04443-006&site=ehost-live&scope=site
UR - deggerth@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04443-009
AN - 2006-04443-009
AU - Eggerth, Donald E.
T1 - The Complicated Pig Speaks: A Reply to Gore and Brown and Tinsley.
JF - Journal of Career Assessment
JO - Journal of Career Assessment
JA - J Career Assess
Y1 - 2006/05//
VL - 14
IS - 2
SP - 289
EP - 291
CY - US
PB - Sage Publications
SN - 1069-0727
SN - 1552-4590
AD - Eggerth, Donald E., Training Research and Evaluation Branch, CDC/NIOSH, 4676 Columbia Parkway, C-10, Cincinnati, OH, US, 45226
N1 - Accession Number: 2006-04443-009. Partial author list: First Author & Affiliation: Eggerth, Donald E.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20060417. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Occupational Choice; Occupational Interest Measures; Occupational Interests; Profiles (Measurement). Minor Descriptor: Person Environment Fit; Self-Congruence. Classification: Occupational & Employment Testing (2228); Occupational Interests & Guidance (3610). References Available: Y. Page Count: 3. Issue Publication Date: May, 2006.
AB - Replies to comments made by Gore and, Brown (see record [rid]2006-04443-007[/rid]) and Tinsley (see record [rid]2006-04443-008[/rid]) on the original article (see record [rid]2006-04443-006[/rid]) which discussed modifying the C Index for use with Holland codes of unequal length. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - C Index modifications
KW - unequal length Holland Codes
KW - Holland's theory
KW - career types
KW - person/occupation congruence
KW - Holland types
KW - 2006
KW - Occupational Choice
KW - Occupational Interest Measures
KW - Occupational Interests
KW - Profiles (Measurement)
KW - Person Environment Fit
KW - Self-Congruence
KW - 2006
DO - 10.1177/1069072705283783
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04443-009&site=ehost-live&scope=site
UR - deggerth@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-04872-004
AN - 2006-04872-004
AU - Duffy, Sarah Q.
AU - Cowell, Alexander J.
AU - Council, Carol Lederhaus
AU - Shi, Weihua
T1 - Formal Treatment, Self-Help, or No Treatment for Alcohol-Use Disorders? Evidence from the National Household Survey on Drug Abuse.
JF - Journal of Studies on Alcohol
JO - Journal of Studies on Alcohol
JA - J Stud Alcohol
Y1 - 2006/05//
VL - 67
IS - 3
SP - 363
EP - 372
CY - US
PB - Alcohol Research Documentation
SN - 0096-882X
AD - Duffy, Sarah Q., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1044, Rockville, MD, US, 20857
N1 - Accession Number: 2006-04872-004. PMID: 16608145 Other Journal Title: Journal of Studies on Alcohol and Drugs; Quarterly Journal of Studies on Alcohol. Partial author list: First Author & Affiliation: Duffy, Sarah Q.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060522. Correction Date: 20081124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Cowell, Alexander J. Major Descriptor: Alcohol Abuse; Alcohol Rehabilitation; Choice Behavior; Drug Abuse; Self-Help Techniques. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: May, 2006.
AB - Objective: The purpose of this study was to examine further alcohol treatment choice by using data from a nationally representative sample of adults with alcohol-use disorders to test which of three models--sequential, multinomial, or nested--best fit the data. The goals were to provide evidence about how this choice was made and to provide improved coefficient estimates, as well as to inform future analyses of treatment choice. Method: Data from the 2000 National Household Survey of Drug Abuse include respondents ages 18-64 reporting symptoms consistent with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnoses of alcohol abuse or dependence. A nested multinomial framework is used to determine the preferred model and to estimate the effect of respondents' characteristics on the decisions to receive help and what kind of help to receive. Results: A sequential model, in which the choice of whether to receive help is unaffected by the level of satisfaction afforded by the alternatives, best fit the data. Older respondents had higher odds of both receiving help and choosing self-help, and those with a DSM-IV diagnosis of abuse had lower odds of receiving help but higher odds of entering self-help. Conclusions: The decision to receive help for alcohol problems appears unaffected by the perceived differences between these two broad categories of alternatives: self-help or formal treatment. This result may indicate the need to provide more information on the full range of treatment options to those for whom self-help may not be sufficient. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol-use disorders
KW - drug abuse
KW - alcohol treatment choice
KW - self-help techniques
KW - 2006
KW - Alcohol Abuse
KW - Alcohol Rehabilitation
KW - Choice Behavior
KW - Drug Abuse
KW - Self-Help Techniques
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 283-99-9018. Recipients: Cowell, Alexander J.; Council, Carol Lederhaus; Shi, Weihua
U1 - Sponsor: National Analytic Center. Other Details: National Household Survey on Drug Abuse. Recipients: No recipient indicated
DO - 10.15288/jsa.2006.67.363
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-04872-004&site=ehost-live&scope=site
UR - Sarah.Duffy@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06858-010
AN - 2006-06858-010
AU - Furniss, Tilman
AU - Beyer, Thomas
AU - Guggenmos, Juergen
T1 - Prevalence of behavioural and emotional problems among six-years-old preschool children: Baseline results of a prospective longitudinal study.
JF - Social Psychiatry and Psychiatric Epidemiology
JO - Social Psychiatry and Psychiatric Epidemiology
JA - Soc Psychiatry Psychiatr Epidemiol
Y1 - 2006/05//
VL - 41
IS - 5
SP - 394
EP - 399
CY - Germany
PB - Springer
SN - 0933-7954
SN - 1433-9285
AD - Furniss, Tilman, Dep. of Child and Adolescent Psychiatry, University Hospital Munster, Schmeddingstrasse 50, 48149, Munster, Germany
N1 - Accession Number: 2006-06858-010. PMID: 16565920 Other Journal Title: Social Psychiatry. Partial author list: First Author & Affiliation: Furniss, Tilman; Dep. of Child and Adolescent Psychiatry, University Hospital Münster, Münster, Germany. Release Date: 20060605. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Problems; Emotional Disturbances; Internalization; Mental Disorders; Preschool Students. Minor Descriptor: Mental Health Services; Psychopathology; Symptoms. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Location: Germany. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: May, 2006.
AB - Objective: To study the prevalence of behavioural and emotional problems and the scope of symptoms in preschool children. The results: serve as baseline in a 4-year follow-up study. Method The sample consisted of 1887 preschool children who started primary level education within 6 months upon data collection. The sample represented the complete 1-year intake of all first year primary school children in a northern German town of 254,000 residents. The data were collected with standardized parent questionnaires. Results: The 6-month prevalence of behavioural and emotional symptoms was 12.4%. The overall score for internalizing symptoms (INT) was significantly higher than the score for externalizing symptoms (EXT). The disturbed children had the highest mean scores on the syndrome scale 'Anxious or Depressed'. Conclusions: The level of psychopathology in preschool children was already as high as levels seen elsewhere in school children. The predominant role of INT was unexpected, particularly for boys. The attention of child mental health services need to focus on preschool children as on school children and on INT as much as on EXT, especially in boys. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral problem
KW - emotional problems
KW - preschool children
KW - symptoms
KW - psychopathology
KW - child mental health services
KW - 2006
KW - Behavior Problems
KW - Emotional Disturbances
KW - Internalization
KW - Mental Disorders
KW - Preschool Students
KW - Mental Health Services
KW - Psychopathology
KW - Symptoms
KW - 2006
DO - 10.1007/s00127-006-0045-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06858-010&site=ehost-live&scope=site
UR - furniss@uni-muenster.de
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06489-004
AN - 2006-06489-004
AU - del Vecchio, Paolo
T1 - All We Are Saying Is Give People With Mental Illnesses a Chance.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/05//
VL - 57
IS - 5
SP - 646
EP - 646
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - del Vecchio, Paolo, Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2006-06489-004. PMID: 16675757 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: del Vecchio, Paolo; Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060710. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Mental Disorders; Mental Health Services; Recovery (Disorders). Minor Descriptor: Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: May, 2006.
AB - Comments on an article by L. Davidson et al (see record [rid]2006-06489-003[/rid]). As a mental health consumer, family member, and professional, I agree with the authors' analysis of recovery and barriers to its implementation, with two major exceptions. First, contrary to the authors' assertion, a consensus is emerging on defining recovery. Second, although I agree with authors that perceived risk is a concern, there is a greater underlying obstacle to achieving recovery. Stigma and discrimination and recovery are inexorably linked: no justice, no recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recovery
KW - mental illness
KW - recovery oriented care
KW - mental health system
KW - 2006
KW - Mental Disorders
KW - Mental Health Services
KW - Recovery (Disorders)
KW - Health Care Policy
KW - 2006
DO - 10.1176/appi.ps.57.5.646
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06489-004&site=ehost-live&scope=site
UR - paolo.delvecchio@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-05664-005
AN - 2006-05664-005
AU - Kirby, James B.
T1 - From Single-Parent Families to Stepfamilies: Is the Transition Associated With Adolescent Alcohol Initiation?
JF - Journal of Family Issues
JO - Journal of Family Issues
JA - J Fam Issues
Y1 - 2006/05//
VL - 27
IS - 5
SP - 685
EP - 711
CY - US
PB - Sage Publications
SN - 0192-513X
SN - 1552-5481
N1 - Accession Number: 2006-05664-005. Partial author list: First Author & Affiliation: Kirby, James B.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20060522. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychology; Alcohol Drinking Patterns; Family Structure; Human Sex Differences; Life Changes. Minor Descriptor: Alcohol Abuse; Single Parents; Stepfamily. Classification: Social Processes & Social Issues (2900). Population: Human (10); Male (30). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 27. Issue Publication Date: May, 2006.
AB - This study addresses two questions: Is stepfamily formation associated with the likelihood that adolescents will initiate alcohol use, and if so, does this association differ by the type of single-parent families from which adolescents move or the type of stepfamilies to which they move? The author found that adolescents who moved to stepfamilies from single-parent families had an elevated risk of initiating alcohol use. A transition from a divorced single-parent family to a stepfamily is associated with an increase in alcohol initiation among boys, but a transition from an unwed single-parent family to a stepfamily is not. In contrast, girls who transition from an unwed single-parent family to a stepfamily show an elevated likelihood of initiating alcohol use, whereas those who transition from divorced single-parent families do not. Adolescents who move to cohabiting stepfamilies do not respond differently than do adolescents who move to married stepfamilies regardless of gender. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - single parent families
KW - adolescent alcohol initiation
KW - stepfamily formation
KW - gender
KW - cumulative stress hypothesis
KW - greater change hypothesis
KW - incomplete institution hypothesis
KW - 2006
KW - Adolescent Psychology
KW - Alcohol Drinking Patterns
KW - Family Structure
KW - Human Sex Differences
KW - Life Changes
KW - Alcohol Abuse
KW - Single Parents
KW - Stepfamily
KW - 2006
DO - 10.1177/0192513X05284855
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-05664-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06489-028
AN - 2006-06489-028
AU - Everett, Anita
T1 - Review of There Aren't Any Kitchens in Heaven.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/05//
VL - 57
IS - 5
SP - 726
EP - 727
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-06489-028. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Everett, Anita; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060710. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Drug Abuse; Family Members; Schizophrenia. Minor Descriptor: Mental Disorders; Motivation. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10). Reviewed Item: Jones, Claudia M. There Aren't Any Kitchens in Heaven=First Books Library, 2003, 136 pages, $11.45 softcover; 2003. Page Count: 2. Issue Publication Date: May, 2006.
AB - Reviews the book There Aren't Any Kitchens in Heaven by Claudia M. Jones (2003). This work provides accounts of life with the author's elder brother, his paranoid schizophrenia, and his associated drug abuse. What is extremely remarkable about this book is the very neutral, unassuming, and accepting way these dramatic events are presented by Dr. Jones. This book would be useful for family members, particularly those near the outset of experiencing mental illness in their family. It would provide validation of some of the experiences family members may have encountered. For seasoned professionals and peers, the book is likely to serve as a reminder of the intensity of the experience of family members. In a best-case scenario, it could even enhance motivation to commit to greater efforts to more directly engage family members in the active treatment of individuals with schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - schizophrenia
KW - drug abuse
KW - family members
KW - mental illness
KW - motivation
KW - 2006
KW - Drug Abuse
KW - Family Members
KW - Schizophrenia
KW - Mental Disorders
KW - Motivation
KW - 2006
U2 - Jones, Claudia M. (2003); There Aren't Any Kitchens in Heaven; First Books Library, 2003, 136 pages, $11.45 softcover
DO - 10.1176/appi.ps.57.5.726-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06489-028&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06489-032
AN - 2006-06489-032
AU - Everett, Anita
T1 - Review of The Necessity of Madness.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/05//
VL - 57
IS - 5
SP - 730
EP - 731
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-06489-032. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Everett, Anita; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20060710. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Mental Disorders; Recovery (Disorders); Spirituality. Minor Descriptor: Peers; Support Groups. Classification: Psychological Disorders (3210). Population: Human (10). Reviewed Item: Breeding, John. The Necessity of Madness=London, Chipmunkapublishing, 2003, 476 pages, $45 softcover; 2003. Page Count: 2. Issue Publication Date: May, 2006.
AB - Reviews the book The Necessity of Madness by John Breeding (2003). The author asserts that 'madness is a dynamic process which can result in breakthroughs to deeper levels of spiritual maturity and a richer fuller life.' This is one of several tenets included in this work that bring a perspective that is inconsistent with the way most professionals and advocates today characterize mental illness, which is exactly the point of this work. If you are looking for a book that depicts many of the themes and ideas that are upheld by individuals who identify with the psychiatric survivor movement, this book would be a very practical resource. The prominent antipsychiatry language distracts from the author's useful ideas regarding recovery and self-care near the end of the book that would be very helpful to certain consumers who are looking for a high level of intellectual peer-to-peer support and exchange of positive and constructive ideas they could incorporate into their own recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - madness
KW - spiritual maturity
KW - mental illness
KW - peer support
KW - recovery
KW - 2006
KW - Mental Disorders
KW - Recovery (Disorders)
KW - Spirituality
KW - Peers
KW - Support Groups
KW - 2006
U2 - Breeding, John. (2003); The Necessity of Madness; London, Chipmunkapublishing, 2003, 476 pages, $45 softcover
DO - 10.1176/appi.ps.57.5.730
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06489-032&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06489-064
AN - 2006-06489-064
AU - Fisher, William H.
T1 - Review of Everything I'm Cracked Up to Be: A Rock & Roll Fairy Tale.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/05//
VL - 57
IS - 5
SP - 748
EP - 749
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-06489-064. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Fisher, William H.; Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20060710. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Coping Behavior; Human Females; Resilience (Psychological); Self-Concept; Self-Disclosure. Minor Descriptor: Alcoholism; Psychology. Classification: Personality Psychology (3100); Sex Roles & Women's Issues (2970). Population: Human (10); Female (40). Reviewed Item: Trynin, Jen. Everything I'm Cracked Up to Be: A Rock & Roll Fairy Tale=New York, Harcourt Trade Publishers, 2006, 355 pages, $23; 2006. Page Count: 2. Issue Publication Date: May, 2006.
AB - Reviews the book Everything I'm Cracked Up to Be: A Rock & Roll Fairy Tale by Jen Trynin (2006). This book is not written from a psychological perspective, obviously, but is nonetheless full of self-insight and frank self-disclosures, including descriptions of her excesses with alcohol and concerns about self-image. Personally, I wish the author had explored her emotional transition from rock star to wife and mother a bit more fully. But hopefully this book will prompt others with similar experiences to share their stories. These accounts should be of particular interest to anyone interested in resiliency and coping in young adults. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - young adults
KW - emotional transition
KW - psychological perspective
KW - resilience
KW - coping
KW - self image
KW - human females
KW - 2006
KW - Coping Behavior
KW - Human Females
KW - Resilience (Psychological)
KW - Self-Concept
KW - Self-Disclosure
KW - Alcoholism
KW - Psychology
KW - 2006
U2 - Trynin, Jen. (2006); Everything I'm Cracked Up to Be: A Rock & Roll Fairy Tale; New York, Harcourt Trade Publishers, 2006, 355 pages, $23
DO - 10.1176/appi.ps.57.5.748-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06489-064&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Schneeman, Barbara
AU - Trumbo, Paula
AU - Ellwood, Kathleen
AU - Satchell, Felicia
T1 - The regulatory process to revise nutrient labeling relative to the Dietary Reference Intakes.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2006/05/02/May2006 Supplement
M3 - Article
SP - 1228S
EP - 1230S
SN - 00029165
AB - The Nutrition Labeling and Education Act of 1990-an amendment to the Federal Food, Drug, and Cosmetic Act-paved the way for significant changes in the labeling of foods, nutrient content, and health claims. This article gives an overview of the regulatory process used by the US Food and Drug Administration to revise the food label relative to the Dietary Reference Intakes and in ways that reflect new scientific knowledge and public health issues. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - 21 CFR
KW - Dietary Reference Intakes
KW - Food and Drug Administration
KW - Nutrition Labeling and Education Act
KW - Recommended Dietary Allowance
N1 - Accession Number: 94314642; Schneeman, Barbara 1; Email Address: bschneem@cfsan.fda.gov; Trumbo, Paula 1; Ellwood, Kathleen 1; Satchell, Felicia 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, CFSAN-ONPLDS, College Park MD; Issue Info: May2006 Supplement, p1228S; Author-Supplied Keyword: 21 CFR; Author-Supplied Keyword: Dietary Reference Intakes; Author-Supplied Keyword: Food and Drug Administration; Author-Supplied Keyword: Nutrition Labeling and Education Act; Author-Supplied Keyword: Recommended Dietary Allowance; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=94314642&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106326600
T1 - The regulatory process to revise nutrient labeling relative to the Dietary Reference Intakes.
AU - Schneeman B
AU - Trumbo P
AU - Ellwood K
AU - Satchell F
Y1 - 2006/05/02/May2006 Supplement
N1 - Accession Number: 106326600. Language: English. Entry Date: 20060901. Revision Date: 20150819. Publication Type: Journal Article. Supplement Title: May2006 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Dietary Reference Intakes
KW - Food Labeling -- Legislation and Jurisprudence
KW - Nutrition Policy
KW - Consumer Health Information -- Legislation and Jurisprudence
KW - Public Health
KW - Nutrition Education -- Legislation and Jurisprudence
KW - United States Food and Drug Administration -- Legislation and Jurisprudence
KW - United States
KW - Dietary Reference Intakes -- Classification
SP - 1228S
EP - 30S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - The Nutrition Labeling and Education Act of 1990-an amendment to the Federal Food, Drug, and Cosmetic Act-paved the way for significant changes in the labeling of foods, nutrient content, and health claims. This article gives an overview of the regulatory process used by the US Food and Drug Administration to revise the food label relative to the Dietary Reference Intakes and in ways that reflect new scientific knowledge and public health issues. Copyright © 2006 American Society for Nutrition
SN - 0002-9165
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, CFSAN-ONPLDS, HFS-800, 5100 Paint Branch Parkway, College Park, MD; bschneem@cfsan.fda.gov
U2 - PMID: 16685070.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106326600&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jung, Seo Jeong
AU - Choi, Sun Ok
AU - Um, So Young
AU - Kim, Joo Il
AU - Choo, Hae Young Park
AU - Choi, Su Young
AU - Chung, Soo Youn
T1 - Prediction of the permeability of drugs through study on quantitative structure–permeability relationship
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2006/05/03/
VL - 41
IS - 2
M3 - Article
SP - 469
EP - 475
SN - 07317085
AB - Abstract: This study is to research the quantitative structure–permeability relationship of 20 drugs having similar structure. Permeability was determined by using the Caco-2 cell in vitro model. The apparent permeability coefficient (P app) of each drug both of apical to basolateral side and basolateral to apical side was measured at the concentration corresponding to 0.1 times the highest dose strength of 250mL dissolved buffer. In order to test the permeability system suitability, we measured the P app of 19 model drugs out of 20 which presented in ‘Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms based on the Biopharmaceutics Classification System’ of FDA guidance. Also, we demonstrated the functional expression of efflux systems (e.g., p-gp) by bi-directional transport studies with rhodamine 123. Also, as a result of the study on quantitative structure–permeability relationship by using the partial least square method, it was possible to predict the permeability of drugs from their 3D structure. The quantitative structure–permeability relationship provided a cross-validated q 2 =0.789, a normal r 2 =0.998. Considering all of above results, analysis on this quantitative structure–permeability relationship appears to be a very useful tool to predict the permeability. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOAVAILABILITY
KW - DOSAGE forms of drugs
KW - DRUG delivery systems
KW - BIOPHARMACEUTICS
KW - Biopharmaceutics classification system (BCS)
KW - Caco-2 cell
KW - Permeability
N1 - Accession Number: 20482762; Jung, Seo Jeong 1 Choi, Sun Ok 1; Email Address: sochoi@kfda.go.kr Um, So Young 1 Kim, Joo Il 1 Choo, Hae Young Park 2 Choi, Su Young 2 Chung, Soo Youn 1; Affiliation: 1: Division of Biopharmaceutics, Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, #231 Jinheungno, Eunpyung-Gu, Seoul, Republic of Korea 2: School of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul, Republic of Korea; Source Info: May2006, Vol. 41 Issue 2, p469; Subject Term: BIOAVAILABILITY; Subject Term: DOSAGE forms of drugs; Subject Term: DRUG delivery systems; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Biopharmaceutics classification system (BCS); Author-Supplied Keyword: Caco-2 cell; Author-Supplied Keyword: Permeability; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2005.12.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20482762&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liang, Fuyan
AU - Lu, Mingming
AU - Birch, M. Eileen
AU - Keener, Tim C.
AU - Liu, Zifei
T1 - Determination of polycyclic aromatic sulfur heterocycles in diesel particulate matter and diesel fuel by gas chromatography with atomic emission detection
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/05/05/
VL - 1114
IS - 1
M3 - Article
SP - 145
EP - 153
SN - 00219673
AB - Abstract: The sulfur content of diesel fuel is of environmental concern because sulfur can facilitate the formation of diesel particulate matter (DPM) and sulfur dioxide (SO2) in the exhaust can poison catalytic converters. The US Environmental Protection Agency (EPA) has established more stringent regulations to reduce the sulfur content of diesel fuels in the near future. In this study, various types of organosulfur compounds in DPM extracts and the corresponding fuels have been determined by gas chromatography with atomic emission detection. The diesel fuels used have sulfur contents of 2284 and 433ppm, respectively, and are labeled as high-sulfur and low-sulfur diesel fuels. The compounds identified are mainly polycyclic aromatic sulfur heterocycles (PASHs). In the fuels tested, trimethylbenzothiophenes (TMBTs), dibenzothiophenes (DBTs), and 4-methyldibenzothiophene (4-MDBT) were the most abundant sulfur compounds, while larger PASH compounds were more abundant in DPM extracts. The high-sulfur diesel fuel contained a larger proportion of PASHs with one or two rings (lighter PASHs). In DPM, the concentrations of total organic sulfur and individual PASHs are higher for the high-sulfur diesel fuel, and the relative percentage of one or two-ring PASHs is higher as well. The influence of engine load on the DPM composition was also examined. With increasing load, the PASH concentration in DPM decreased for lighter PASHs, increased for heavier PASHs, and had a bell-shaped distribution for PASHs in between. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel fuels
KW - Gas chromatography
KW - Polycyclic aromatic compounds
KW - Atomic emission spectroscopy
KW - Diesel fuel
KW - Diesel particulate matter
KW - Engine load
KW - GC/AED
KW - PASH
N1 - Accession Number: 20401648; Liang, Fuyan 1; Lu, Mingming 1; Email Address: mingming.lu@uc.edu; Birch, M. Eileen 2; Keener, Tim C. 1; Liu, Zifei 1; Affiliations: 1: Department of Civil and Environmental Engineering, University of Cincinnati, P.O. Box 210071, Cincinnati, OH 45221, USA; 2: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: May2006, Vol. 1114 Issue 1, p145; Thesaurus Term: Diesel fuels; Thesaurus Term: Gas chromatography; Thesaurus Term: Polycyclic aromatic compounds; Subject Term: Atomic emission spectroscopy; Author-Supplied Keyword: Diesel fuel; Author-Supplied Keyword: Diesel particulate matter; Author-Supplied Keyword: Engine load; Author-Supplied Keyword: GC/AED; Author-Supplied Keyword: PASH; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 454319 Other fuel dealers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2006.02.096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20401648&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xia, Qingsu
AU - Yin, Jun Jie
AU - Cherng, Shu-Hui
AU - Wamer, Wayne G.
AU - Boudreau, Mary
AU - Howard, Paul C.
AU - Fu, Peter P.
T1 - UVA photoirradiation of retinyl palmitate—Formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2006/05/05/
VL - 163
IS - 1
M3 - Article
SP - 30
EP - 43
SN - 03784274
AB - Abstract: We have previously reported that photoirradiation of retinyl palmitate (RP) in ethanol with UVA light results in the formation of photodecomposition products, including 5,6-epoxy-RP and anhydroretinol (AR). Photoirradiation in the presence of a lipid, methyl linoleate, induced lipid peroxidation, suggesting that reactive oxygen species (ROS) are formed. In the present study, we employ an electron spin resonance (ESR) spin trap technique to provide direct evidence as to whether or not photoirradiation of RP by UVA light produces ROS. Photoirradiation of RP by UVA in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. Both 5,5-dimethyl N-oxide pyrroline (DMPO) and 5-tert-butoxycarbonyl 5-methyl-1-pyrroline N-oxide (BMPO) are specific probes for superoxide. When photoirradiation of RP was conducted in the presence of the DMPO or BMPO, ESR signals for DMPO-PO-obtained. These results unambiguously confirmed the formation of superoxide radical anion. Consistent with a free radical mechanism, there was a near complete and time-dependent photodecomposition of RP and its photodecomposition products. ESR studies on the photoirradiation of 5,6-epoxy-RP and AR indicate that these compounds exhibit similar photosensitizing activities as RP under UVA light. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Photosynthetic oxygen evolution
KW - Oxygen
KW - Electron spin resonance dating
KW - Peroxidation
KW - ESR
KW - Lipid peroxidation
KW - Photoirradiation
KW - Reactive oxygen species
KW - Retinyl palmitate
KW - UVA
N1 - Accession Number: 20011889; Xia, Qingsu 1; Yin, Jun Jie 2; Cherng, Shu-Hui 1; Wamer, Wayne G. 2; Boudreau, Mary 1; Howard, Paul C. 1; Fu, Peter P. 1; Email Address: pfu@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Department of Biochemical Toxicology, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Issue Info: May2006, Vol. 163 Issue 1, p30; Thesaurus Term: Photosynthetic oxygen evolution; Thesaurus Term: Oxygen; Subject Term: Electron spin resonance dating; Subject Term: Peroxidation; Author-Supplied Keyword: ESR; Author-Supplied Keyword: Lipid peroxidation; Author-Supplied Keyword: Photoirradiation; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Retinyl palmitate; Author-Supplied Keyword: UVA; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.toxlet.2005.09.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20011889&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Harris, Gerald R.
T1 - The FDA Perspective on Pre-Clinical Testing for High Intensity Focused Ultrasound Devices.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2006/05/08/
VL - 829
IS - 1
M3 - Article
SP - 595
EP - 598
PB - American Institute of Physics
SN - 0094243X
AB - In the U. S., the pre-market review of high intensity focused ultrasound (HIFU) devices is carried out under the authority of the 1976 Medical Device Amendments to the Food, Drug, and Cosmetic Act. Different regulatory mechanisms may apply depending on the complexity of the HIFU device and the indications for use, but in all cases pre-clinical testing is required. This testing typically includes ultrasound field characterization, thermal modeling and measurement, and may include demonstrating the accuracy of targeting and monitoring, if applicable. Because there are no guidance documents or standards for these tests at present, the U.S. Food and Drug Administration (FDA) welcomes working with interested parties to develop acceptable procedures that can be incorporated into the regulatory review process. © 2006 American Institute of Physics [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC imaging
KW - ACOUSTIC imaging
KW - IMAGING systems in medicine
KW - MEDICAL equipment
KW - UNITED States
KW - high intensity focused ultrasound
KW - medical device regulation
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20854776; Harris, Gerald R. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852; Source Info: 2006, Vol. 829 Issue 1, p595; Subject Term: ULTRASONIC imaging; Subject Term: ACOUSTIC imaging; Subject Term: IMAGING systems in medicine; Subject Term: MEDICAL equipment; Subject Term: UNITED States; Author-Supplied Keyword: high intensity focused ultrasound; Author-Supplied Keyword: medical device regulation; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1063/1.2205543
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maruvada, Subha
AU - Harris, Gerald R.
AU - Herman, Bruce A.
AU - King, Randy L.
T1 - Analysis of a Protocol for Measuring Ultrasonic Power from Focused Therapeutic Ultrasound Transducers Using Radiation Force.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2006/05/08/
VL - 829
IS - 1
M3 - Article
SP - 623
EP - 627
PB - American Institute of Physics
SN - 0094243X
AB - To address the challenges associated with measuring the ultrasonic power from high intensity focused ultrasound transducers via radiation force, a protocol based on pulsed measurements was analyzed. Two focused ultrasound transducers were characterized in terms of an effective duty factor, which was then used to calculate the power during the pulse at high drive levels. Two absorbing target designs were used, and both gave accurate, reproducible results and displayed no damage and minimal temperature rise if placed near the transducer and away from the focus. The protocol was accurate up to the maximum power generated of approximately 180 W. © 2006 American Institute of Physics [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC imaging
KW - ACOUSTIC imaging
KW - IMAGING systems in medicine
KW - THERMOCOUPLES
KW - THERMOMETERS
KW - TEMPERATURE measurements
KW - High intensity focused ultrasound
KW - Radiation force
KW - Ultrasound power measurement
N1 - Accession Number: 20854770; Maruvada, Subha 1 Harris, Gerald R. 1 Herman, Bruce A. 1 King, Randy L. 2; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, 9200 Corporate Blvd., Mail Stop HFZ-170, Rockville, MD 20850 2: King Acoustic Technologies, LLQ 4481 MacArthur Blvd. NW +ACM-B3, Washington DC 20007; Source Info: 2006, Vol. 829 Issue 1, p623; Subject Term: ULTRASONIC imaging; Subject Term: ACOUSTIC imaging; Subject Term: IMAGING systems in medicine; Subject Term: THERMOCOUPLES; Subject Term: THERMOMETERS; Subject Term: TEMPERATURE measurements; Author-Supplied Keyword: High intensity focused ultrasound; Author-Supplied Keyword: Radiation force; Author-Supplied Keyword: Ultrasound power measurement; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1063/1.2205549
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hastings, Kenneth
T1 - Risk Assessment in Drug Development: Autoimmunity.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2006/05/08/
VL - 69
IS - 9/10
M3 - Article
SP - 893
EP - 898
SN - 15287394
AB - Autoimmunity is a physiological condition in which the immune system responds to normal tissues as if they were foreign pathogens. If this reaction produces pathology, it is referred to as autoimmune disease. Many human diseases (most often chronic in nature) appear to have an autoimmune basis. No model exists that has proven to be sufficiently predictive to screen drugs for potential to induce autoimmunity (hazard identification); thus, it seems somewhat illogical to consider this as an example of risk assessment. However, given the knowledge currently available, it is at least conceivable that drugs could be identified as having the potential to produce autoimmune reactions, and especially to predict the conditions under which autoimmune disease may be induced. This has proven to be an especially important topic with protein drugs designed to replace endogenous molecules. Immunogenicity, thought to be an important component of protein drug-induced autoimmunity, can be modeled in animals. However, interpretation of results with respect to prediction of ability to induce autoimmune disease remains a serious challenge. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNITY
KW - HEALTH risk assessment
KW - DRUG development
KW - IMMUNE response -- Regulation
KW - PATHOGENIC microorganisms
KW - AUTOIMMUNE diseases
KW - IMMUNE system
KW - IMMUNOGENETICS
KW - PROTEIN drugs
N1 - Accession Number: 20617862; Hastings, Kenneth 1; Email Address: hastingsk@cder.fda.gov; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Marykand, USA; Source Info: May2006, Vol. 69 Issue 9/10, p893; Subject Term: AUTOIMMUNITY; Subject Term: HEALTH risk assessment; Subject Term: DRUG development; Subject Term: IMMUNE response -- Regulation; Subject Term: PATHOGENIC microorganisms; Subject Term: AUTOIMMUNE diseases; Subject Term: IMMUNE system; Subject Term: IMMUNOGENETICS; Subject Term: PROTEIN drugs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/15287390600591736
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20617862&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krynitsky, Alexander J.
AU - Niemann, Richard A.
AU - Williams, Anthony D.
AU - Hopper, Marvin L.
T1 - Streamlined sample preparation procedure for determination of perchlorate anion in foods by ion chromatography–tandem mass spectrometry
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2006/05/10/
VL - 567
IS - 1
M3 - Article
SP - 94
EP - 99
SN - 00032670
AB - Abstract: A rapid, sensitive, and specific method was developed for the determination of perchlorate anion in foods. The foods included high moisture fruits and vegetables, low moisture foods (e.g. wheat flour and corn meal), and infant foods. Improvements to existing procedures were made in sample preparation that reduced sample test portion size from 100 to 5 or 10g, extraction solvent volume from 150 to 20–40ml, and replaced blending extraction–vacuum filtration and their associated large glassware with a simple shakeout-centrifugation in a small conical tube. Procedures common to all matrices involved: extraction, centrifugation, graphitized carbon solid phase extraction (SPE) cleanup, and ion chromatography–tandem mass spectrometry (IC–MS/MS) analysis. A Waters IC-Pak Anion HR column (4.6mm×75mm) was eluted with 100mM ammonium acetate in 50:50 (v/v) acetonitrile/water mobile phase at a rate of 0.35ml/min. A triple stage quadrupole mass spectrometer, equipped with electrospray ionization (ESI) in the negative ion mode, was used to detect perchlorate anion. An 18O4-labeled perchlorate anion internal standard was used to correct for any matrix effects. The method limit of quantitation (LOQ) was: 1.0μg/kg in fruits, vegetables, and infant foods; 3.0μg/kg in dry products. Fortified test portions gave 80–120% recoveries. Determination of incurred perchlorate anion residues agreed well with results for comparable commodities or products analyzed by published methods. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEPARATION (Technology)
KW - MASS spectrometry
KW - MOISTURE
KW - HORTICULTURAL products
KW - Foods
KW - IC–MS/MS
KW - Perchlorate anion
KW - SPE
N1 - Accession Number: 20822523; Krynitsky, Alexander J. 1; Email Address: Alex.Krynitsky@fda.hhs.gov Niemann, Richard A. 1 Williams, Anthony D. 2 Hopper, Marvin L. 3; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, United States 2: Southeastern Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth Street NE, Atlanta, GA 30309, United States 3: Total Diet Research Center, U.S. Food and Drug Administration, 11630 West 80th Street, Lenexa, KS 66214, United States; Source Info: May2006, Vol. 567 Issue 1, p94; Subject Term: SEPARATION (Technology); Subject Term: MASS spectrometry; Subject Term: MOISTURE; Subject Term: HORTICULTURAL products; Author-Supplied Keyword: Foods; Author-Supplied Keyword: IC–MS/MS; Author-Supplied Keyword: Perchlorate anion; Author-Supplied Keyword: SPE; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.aca.2006.01.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20822523&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106230592
T1 - Putting prevention into practice: an evidence-based approach. Screening for overweight in children and adolescents.
AU - Mabry IR
Y1 - 2006/05/15/
N1 - Accession Number: 106230592. Language: English. Entry Date: 20070202. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; forms. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Obesity
KW - Adolescence
KW - Adult
KW - Body Mass Index
KW - Child
KW - Child, Preschool
KW - Education, Continuing (Credit)
KW - Female
KW - Growth
KW - Hyperlipidemia
KW - Hypertension
KW - Insulin Resistance
KW - Male
KW - Obesity -- Complications
KW - Obesity -- Epidemiology
KW - Obesity -- Prevention and Control
KW - Professional Practice, Evidence-Based
KW - Race Factors
SP - 1795
EP - 1848
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 73
IS - 10
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 16734059.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106230592&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Montello, Michael J.
AU - Tarosky, Matthew
AU - Pincock, Laura
AU - Montello, Nicole
AU - Hess, William Albert
AU - Velasquez, Lydia
AU - Patel, Arti
AU - Krzyworzeka, Julia
AU - Hay, Elizabeth
T1 - Dosing cards for treatment of children exposed to weapons of mass destruction.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2006/05/15/
VL - 63
IS - 10
M3 - Article
SP - 944
EP - 949
PB - American Society of Health System Pharmacists
SN - 10792082
AB - The article focuses on the efforts of the U.S. Public Health Service to develop and produce weapons of mass destruction (WMD) pediatric dosing cards to improve response time and minimize risk. These cards provide standardized and simplified instructions to prepare and administer antidotes, treatments and prophylactic medications to young victims exposed to WMD.
KW - WEAPONS of mass destruction
KW - ANTIDOTES
KW - PUBLIC health
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 20879813; Montello, Michael J. 1; Email Address: montellom@ctep.nci.nih.gov Tarosky, Matthew 2 Pincock, Laura 3 Montello, Nicole 4 Hess, William Albert 5 Velasquez, Lydia 5 Patel, Arti 5 Krzyworzeka, Julia 6 Hay, Elizabeth 6; Affiliation: 1: Head of the Protocol and Information Office, National Cancer Institute, Rockville 2: Pharmacist, Center for Devices and Radiological Health, Food and Drug Administration (FDA), Rockville 3: Deputy Chief Pharmacist and Safety Evaluator, Center for Drug Evaluation and Research (CDER), Silver Spring 4: Pharmacist, Costco Pharmacy, Southbury 5: Global Health Development, Capital Technology Information Systems, Rockville 6: Philadelphia College of Pharmacy, Philadelphia, PA; Source Info: 5/15/2006, Vol. 63 Issue 10, p944; Subject Term: WEAPONS of mass destruction; Subject Term: ANTIDOTES; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.2146/ajhp050372
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20879813&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marks, W. H.
AU - Wagner, D.
AU - Pearson, T. C.
AU - Orlowski, J. P.
AU - Nelson, P. W.
AU - McGowan, J. J.
AU - Guidinger, M. K.
AU - Burdick, J.
T1 - Organ Donation and Utilization, 1995–2004: Entering the Collaborative Era.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2006/05/15/May2006 Supplement
VL - 6
M3 - Article
SP - 1101
EP - 1110
PB - Wiley-Blackwell
SN - 16006135
AB - Continued progress in organ donation will help enable transplantation to alleviate the increasing incidence of end-stage organ disease. This article discusses the implementation and effect of the federally initiated Organ Donation Breakthrough Collaborative; it then reviews organ donation data, living and deceased, from 1995 to 2004. It is the first annual report of the Scientific Registry of Transplant Recipients to include national data following initiation of the collaborative in 2003. Prior to that, annual growth in deceased donation was 2%–4%; in 2004, after initiation of the collaborative, deceased donation increased 11%. Identification and dissemination of best practices for organ donation have emphasized new strategies for improved consent, including revised approaches to minority participation, timing of requests and team design. The number of organs recovered from donation after cardiac death (DCD) grew from 64 in 1995 to 391 in 2004. While efforts are ongoing to develop methodologies for identifying expanded criteria donors (ECD) for organs other than kidney, it is clear DCD and ECD raise questions regarding cost and recovery. The number of living donor organs increased from 3493 in 1995 to 7002 in 2004; data show trends toward more living unrelated donors and those providing non-directed donations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DONATION of organs, tissues, etc.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - ORGAN donors
KW - PROCUREMENT of organs, tissues, etc.
KW - MEDICAL ethics
KW - Deceased donors
KW - donation after cardiac death (DCD)
KW - donation service area (DSA)
KW - expanded criteria donors
KW - living donors
KW - organ donation
KW - Organ Donation Breakthrough Collaborative
KW - organ procurement
KW - organ procurement organization (OPO) SRTR
N1 - Accession Number: 20386639; Marks, W. H. 1; Email Address: Dmrk8@aol.com Wagner, D. 2 Pearson, T. C. 3 Orlowski, J. P. 4 Nelson, P. W. 5 McGowan, J. J. 6 Guidinger, M. K. 6 Burdick, J. 2; Affiliation: 1: Swedish Medical Center, Seattle, WA, USA 2: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD, USA 3: Emory University Hospital, Atlanta, GA, USA 4: Center for Donation & Transplant, Albany, NY, USA 5: St. Luke's Hospital, Kansas City, MO, USA 6: Scientific Registry of Transplant Recipients, University Renal Research and Education Association, Ann Arbor, MI, USA; Source Info: May2006 Supplement, Vol. 6, p1101; Subject Term: DONATION of organs, tissues, etc.; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: ORGAN donors; Subject Term: PROCUREMENT of organs, tissues, etc.; Subject Term: MEDICAL ethics; Author-Supplied Keyword: Deceased donors; Author-Supplied Keyword: donation after cardiac death (DCD); Author-Supplied Keyword: donation service area (DSA); Author-Supplied Keyword: expanded criteria donors; Author-Supplied Keyword: living donors; Author-Supplied Keyword: organ donation; Author-Supplied Keyword: Organ Donation Breakthrough Collaborative; Author-Supplied Keyword: organ procurement; Author-Supplied Keyword: organ procurement organization (OPO) SRTR; Number of Pages: 10p; Illustrations: 9 Charts, 6 Graphs, 1 Map; Document Type: Article
L3 - 10.1111/j.1600-6143.2006.01269.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20386639&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sweet, S. C.
AU - Wong, H.-H.
AU - Webber, S. A.
AU - Horslen, S.
AU - Guidinger, M. K.
AU - Fine, R. N.
AU - Magee, J. C.
T1 - Pediatric Transplantation in the United States, 1995–2004.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2006/05/15/May2006 Supplement
VL - 6
M3 - Article
SP - 1132
EP - 1152
PB - Wiley-Blackwell
SN - 16006135
AB - This article reviews trends in pediatric solid organ transplantation over the last decade, as reflected in OPTN/SRTR data. In 2004, children younger than 18 years made up nearly 3% of the 86 378 candidates for organ transplantation and nearly 7% of the 27 031 organ transplant recipients. Children accounted for nearly 14% of the 7152 deceased organ donors. The transplant community recognizes important differences between pediatric and adult organ transplant recipients, including different etiologies of organ failure, surgical procedures that are more complex or technically challenging, effects of development on the pharmacokinetic properties of common immunosuppressants, unique immunological aspects of transplant in the developing immune system and increased susceptibility to posttransplant complications, particularly infectious diseases. For these reasons, and because of the impact of end-stage organ failure on growth and development, the transplant community has generally provided pediatric candidates with special consideration in the allocation of deceased donor organs. Outcomes following kidney, liver and heart transplantation in children often rank among the best. This article emphasizes that the prospects for solid organ transplantation in children, especially those aged 1–10 years are excellent. It also identifies themes warranting further consideration, including organ availability, adolescent survival and challenges facing pediatric transplant clinical research. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - PEDIATRICS
KW - DONATION of organs, tissues, etc.
KW - ORGAN donors
KW - UNITED States
KW - Deceased donors
KW - graft survival
KW - immunosuppression
KW - living donors
KW - OPTN
KW - organ donation
KW - patient survival
KW - pediatric transplantation
KW - SRTR
KW - waiting list
N1 - Accession Number: 20386637; Sweet, S. C. 1; Email Address: sweet@kids.wustl.edu Wong, H.-H. 2 Webber, S. A. 3 Horslen, S. 4 Guidinger, M. K. 5 Fine, R. N. 6 Magee, J. C. 7; Affiliation: 1: Washington University School of Medicine, St. Louis, MO, USA 2: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD, USA 3: Children's Hospital of Pittsburgh, Pittsburgh, PA, USA 4: Children's Hospital and Regional Medical Center, Seattle, WA, USA 5: Scientific Registry of Transplant Recipients, University Renal Research and Education Association, Ann Arbor, MI, USA 6: Stony Brook University School of Medicine, Stony Brook, NY, USA 7: Scientific Registry of Transplant Recipients, University of Michigan, Ann Arbor, MI, USA; Source Info: May2006 Supplement, Vol. 6, p1132; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: PEDIATRICS; Subject Term: DONATION of organs, tissues, etc.; Subject Term: ORGAN donors; Subject Term: UNITED States; Author-Supplied Keyword: Deceased donors; Author-Supplied Keyword: graft survival; Author-Supplied Keyword: immunosuppression; Author-Supplied Keyword: living donors; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: organ donation; Author-Supplied Keyword: patient survival; Author-Supplied Keyword: pediatric transplantation; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: waiting list; Number of Pages: 21p; Illustrations: 3 Charts, 29 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2006.01271.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20386637&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, D. J.
AU - St. Martin, L.
AU - Christensen, L. L.
AU - Bloom, R. D.
AU - Sung, R. S.
T1 - Kidney and Pancreas Transplantation in the United States, 1995–2004.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2006/05/15/May2006 Supplement
VL - 6
M3 - Article
SP - 1153
EP - 1169
PB - Wiley-Blackwell
SN - 16006135
AB - This article examines OPTN/SRTR data on kidney and pancreas transplantation for 2004 and the previous decade, and discusses recent changes in kidney-pancreas (KP) allocation policy and emerging issues in kidney donation after cardiac death (DCD). Although the number of kidney donors continues to increase, new waiting list registrations again outpaced the number of kidney transplants performed, rising by 11% between 2003 and 2004 and contributing to a 1-year increase of 8% in the number of patients active on the waiting list. DCD has increased steadily since 2000; 39% more DCD transplants were performed in 2004 than 2003. Both deceased donor and living donor kidney graft survival rates remain excellent and are improving. The number of people living with a functioning kidney transplant doubled between 1995 and 2004, to 101 440 with a functioning kidney-alone and 7213 with a functioning KP. Health care providers in all settings are more likely to be exposed to these transplant recipients. Patient survival following simultaneous pancreas-kidney (SPK) transplantation is excellent and has improved incrementally since 1995; death rates in the first year fell from 60 per 1000 patient-years at risk in 2001 to 45 in 2003. The number of solitary pancreas transplants increased dramatically in 2004. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KIDNEY transplants
KW - PANCREAS -- Transplantation
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DONATION of organs, tissues, etc.
KW - UNITED States
KW - Deceased donors
KW - graft survival
KW - kidney transplantation
KW - kidney-pancreas transplantation
KW - living donors
KW - organ donation
KW - pancreas transplantation
KW - patient survival
KW - SRTR
KW - waiting list
N1 - Accession Number: 20386636; Cohen, D. J. 1; Email Address: djc5@columbia.edu St. Martin, L. 2 Christensen, L. L. 3 Bloom, R. D. 4 Sung, R. S. 5; Affiliation: 1: Columbia University Medical Center, New York, NY, USA 2: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD, USA 3: Scientific Registry of Transplant Recipients, University Renal Research and Education Association, Ann Arbor, MI, USA 4: University of Pennsylvania, Philadelphia, PA, USA 5: Scientific Registry of Transplant Recipients, University of Michigan, Ann Arbor, MI, USA; Source Info: May2006 Supplement, Vol. 6, p1153; Subject Term: KIDNEY transplants; Subject Term: PANCREAS -- Transplantation; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DONATION of organs, tissues, etc.; Subject Term: UNITED States; Author-Supplied Keyword: Deceased donors; Author-Supplied Keyword: graft survival; Author-Supplied Keyword: kidney transplantation; Author-Supplied Keyword: kidney-pancreas transplantation; Author-Supplied Keyword: living donors; Author-Supplied Keyword: organ donation; Author-Supplied Keyword: pancreas transplantation; Author-Supplied Keyword: patient survival; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: waiting list; Number of Pages: 17p; Illustrations: 2 Charts, 12 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2006.01272.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20386636&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dickinson, D. M.
AU - Shearon, T. H.
AU - O'Keefe, J.
AU - Wong, H.-H.
AU - Berg, C. L.
AU - Rosendale, J. D.
AU - Delmonico, F. L.
AU - Webb, R. L.
AU - Wolfe, R. A.
T1 - SRTR Center-Specific Reporting Tools: Posttransplant Outcomes.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2006/05/15/May2006 Supplement
VL - 6
M3 - Article
SP - 1198
EP - 1211
PB - Wiley-Blackwell
SN - 16006135
AB - Measuring and monitoring performance—be it waiting list and posttransplant outcomes by a transplant center, or organ donation success by an organ procurement organization and its partnering hospitals—is an important component of ensuring good care for people with end-stage organ failure. Many parties have an interest in examining these outcomes, from patients and their families to payers such as insurance companies or the Centers for Medicare and Medicaid Services; from primary caregivers providing patient counseling to government agencies charged with protecting patients. The Scientific Registry of Transplant Recipients produces regular, public reports on the performance of transplant centers and organ procurement organizations. This article explains the statistical tools used to prepare these reports, with a focus on graft survival and patient survival rates of transplant centers—especially the methods used to fairly and usefully compare outcomes of centers that serve different populations. The article concludes with a practical application of these statistics—their use in screening transplant center performance to identify centers that may need remedial action by the OPTN/UNOS Membership and Professional Standards Committee. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHODOLOGY
KW - PATIENTS
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DONATION of organs, tissues, etc.
KW - HOSPITALS
KW - Methodology
KW - OPTN
KW - patient survival
KW - professional standards
KW - risk adjustment
KW - SRTR
KW - transplant center performance
KW - transplant data
N1 - Accession Number: 20386633; Dickinson, D. M. 1; Email Address: dickinsn@urrea.org Shearon, T. H. 2 O'Keefe, J. 3 Wong, H.-H. 4 Berg, C. L. 5 Rosendale, J. D. 3 Delmonico, F. L. 6 Webb, R. L. 2 Wolfe, R. A. 1; Affiliation: 1: Scientific Registry of Transplant Recipients, University Renal Research and Education Association 2: Scientific Registry of Transplant Recipients, University of Michigan 3: Organ Procurement and Transplantation Network/United Network for Organ Sharing 4: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Department of Transplantation 5: University of Virginia 6: Harvard Medical School; Source Info: May2006 Supplement, Vol. 6, p1198; Subject Term: METHODOLOGY; Subject Term: PATIENTS; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DONATION of organs, tissues, etc.; Subject Term: HOSPITALS; Author-Supplied Keyword: Methodology; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: patient survival; Author-Supplied Keyword: professional standards; Author-Supplied Keyword: risk adjustment; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: transplant center performance; Author-Supplied Keyword: transplant data; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 14p; Illustrations: 1 Diagram, 12 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2006.01275.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20386633&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dheenadhayalan, Veerabadran
AU - Delogu, Giovanni
AU - Sanguinetti, Maurizio
AU - Fadda, Giovanni
AU - Brennan, Michael J.
T1 - Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2006/05/15/
VL - 188
IS - 10
M3 - Article
SP - 27
EP - 27
SN - 00219193
AB - Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM tuberculosis
KW - GENE expression
KW - GENES
KW - MACROPHAGES
KW - MYCOBACTERIUM
N1 - Accession Number: 20962356; Dheenadhayalan, Veerabadran 1 Delogu, Giovanni 2 Sanguinetti, Maurizio 2 Fadda, Giovanni 2 Brennan, Michael J. 1; Email Address: michael.brennan@fda.hhs.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy; Source Info: May2006, Vol. 188 Issue 10, p27; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: GENE expression; Subject Term: GENES; Subject Term: MACROPHAGES; Subject Term: MYCOBACTERIUM; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.188.10.3721-3725.2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20962356&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Laassri, Majid
AU - Lottenbach, Kathleen
AU - Belshe, Robert
AU - Rennels, Margaret
AU - Plotkin, Stanley
AU - Chumakov, Konstantin
T1 - Analysis of Reversions in the 5'-Untranslated Region of Attenuated Poliovirus after Sequential Administration of Inactivated and Oral Poliovirus Vaccines.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/05/15/
VL - 193
IS - 10
M3 - Article
SP - 1344
EP - 1349
SN - 00221899
AB - Replication of Sabin strains used in oral poliovirus vaccine (OPV) in the intestines of vaccine recipients leads to reversions that increase virus neurovirulence. Previously, a small study reported that prior immunization with inactivated poliovirus vaccine (IPV) resulted in faster accumulation of revertant virus, thus potentially increasing the risk of vaccine-associated paralytic poliomyelitis. We studied the impact that prior immunization with IPV and OPV has on shedding of revertant virus by healthy infants. By polymerase chain reaction (PCR), we amplified full-length poliovirus genomes directly from stool specimens from unimmunized infants and from infants previously immunized with IPV or OPV. The amplicons were used to quantify reversions in the 5'-untranslated region, using oligonucleotide microarray hybridization. Nearly all 140 samples that were PCR positive contained varying amounts of revertants of all 3 poliovirus serotypes. Polioviruses of Sabin types 2 and 3 reverted more easily than those of type 1. Prior vaccination with IPV did not increase the proportion of revertants after OPV administration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIOVIRUS
KW - VACCINATION
KW - IMMUNIZATION
KW - POLYMERASE chain reaction
KW - GENOMES
N1 - Accession Number: 20808833; Laassri, Majid 1 Lottenbach, Kathleen 2 Belshe, Robert 2 Rennels, Margaret 3 Plotkin, Stanley 4 Chumakov, Konstantin 1; Email Address: chumakov@cber.fda.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville 2: Saint Louis University, Saint Louis, Missouri 3: University of Maryland School of Medicine, Baltimore, Maryland 4: University of Pennsylvania and Sanofi Pasteur, Doylestown; Source Info: 5/15/2006, Vol. 193 Issue 10, p1344; Subject Term: POLIOVIRUS; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: POLYMERASE chain reaction; Subject Term: GENOMES; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106352057
T1 - Analysis of reversions in the 5'-untranslated region of attenuated poliovirus after sequential administration of inactivated and oral poliovirus vaccines.
AU - Laassri M
AU - Lottenbach K
AU - Belshe R
AU - Rennels M
AU - Plotkin S
AU - Chumakov K
Y1 - 2006/05/15/
N1 - Accession Number: 106352057. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; pictorial; research; tables/charts. Commentary: Kew O. What role for inactivated poliovirus vaccine in the eradication endgame? (J INFECT DIS) 5/15/2006; 193 (10): 1341-1343. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Defense Advanced Research Projects Agency (grant); National Vaccine Program Office (grant); National Institute of Allergy and Infectious diseases (contracts NO1-AI-45250, NO1-AI-45251). NLM UID: 0413675.
KW - Poliomyelitis -- Prevention and Control
KW - Poliovirus Vaccine -- Therapeutic Use
KW - Academic Medical Centers
KW - Clinical Trials
KW - Comparative Studies
KW - Descriptive Statistics
KW - Funding Source
KW - Genome
KW - Human
KW - Immunization Schedule
KW - In Situ Hybridization, Fluorescence
KW - Infant
KW - Maryland
KW - Mutation
KW - Poliomyelitis -- Familial and Genetic
KW - Poliomyelitis -- Immunology
KW - Poliovirus Vaccine -- Adverse Effects
KW - Poliovirus Vaccine -- Immunology
KW - Poliovirus Vaccine -- Pharmacodynamics
KW - Poliovirus Vaccine, Inactivated -- Administration and Dosage
KW - Poliovirus Vaccine, Oral -- Administration and Dosage
KW - Polymerase Chain Reaction
KW - Virulence
SP - 1344
EP - 1349
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 193
IS - 10
PB - Oxford University Press / USA
AB - Replication of Sabin strains used in oral poliovirus vaccine (OPV) in the intestines of vaccine recipients leads to reversions that increase virus neurovirulence. Previously, a small study reported that prior immunization with inactivated poliovirus vaccine (IPV) resulted in faster accumulation of revertant virus, thus potentially increasing the risk of vaccine-associated paralytic poliomyelitis. We studied the impact that prior immunization with IPV and OPV has on shedding of revertant virus by healthy infants. By polymerase chain reaction (PCR), we amplified full-length poliovirus genomes directly from stool specimens from unimmunized infants and from infants previously immunized with IPV or OPV. The amplicons were used to quantify reversions in the 5'-untranslated region, using oligonucleotide microarray hybridization. Nearly all 140 samples that were PCR positive contained varying amounts of revertants of all 3 poliovirus serotypes. Polioviruses of Sabin types 2 and 3 reverted more easily than those of type 1. Prior vaccination with IPV did not increase the proportion of revertants after OPV administration. Copyright © 2006 Infectious Diseases Society of America
SN - 0022-1899
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA.
U2 - PMID: 16619180.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106352057&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bo Chi
AU - Dickensheets, Harold L.
AU - Spann, Kirsten M.
AU - Alston, Marc A.
AU - Luongo, Cindy
AU - Dumoutier, Laure
AU - Jiaying Huang
AU - Renauld, Jean-Christophe
AU - Kotenko, Sergei V.
AU - Roederer, Mario
AU - Beeler, Judy A.
AU - Donnelly, Raymond P.
AU - Collins, Peter L.
AU - Rabin, Ronald L.
T1 - Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/05/15/
VL - 80
IS - 10
M3 - Article
SP - 15
EP - 15
SN - 0022538X
AB - The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) and CD4 T cells and measured [³H]thymidine incorporation to determine the factors responsible for RSV-induced T-cell suppression. These two cell types were sufficient for RSV-induced suppression of T-cell proliferation in response to cytomegalovirus or Staphylococcus enterotoxin B. Suppressive activity was transferable with supernatants from RSV-infected MDDC and was not due to transfer of live virus or RSV F (fusion) protein. Supernatants from RSV-infected MDDC, but not MDDC exposed to UV-killed RSV or mock conditions, contained alpha interferon (IFN-α; median, 43 pg/ml) and IFN-λ (approximately 1 to 20 ng/ml). Neutralization of IFN-α with monoclonal antibody (MAb) against one of its receptor chains, IFNAR2, or of IFN-λ with MAb against either of its receptor chains, IFN-λR1 (interleukin 28R [IL-28R]) or IL-10R2, had a modest effect. In contrast, blocking the two receptors together markedly reduced or completely blocked the RSV-induced suppression of CD4 T-cell proliferation. Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - T cells
KW - ANTIGENS
KW - DENDRITIC cells
KW - THYMIDINE
N1 - Accession Number: 20839387; Bo Chi 1 Dickensheets, Harold L. 2 Spann, Kirsten M. 3 Alston, Marc A. 1 Luongo, Cindy 3 Dumoutier, Laure 4 Jiaying Huang 5 Renauld, Jean-Christophe 4 Kotenko, Sergei V. 5 Roederer, Mario 3 Beeler, Judy A. 1 Donnelly, Raymond P. 2 Collins, Peter L. 3 Rabin, Ronald L. 1; Email Address: rrabin@helix.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Bethesda, Maryland 2: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 3: National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 4: Ludwig Institute for Cancer Research, Brussels Branch, and Experimental Medicine Unit, Université de Louvain, Brussels, Belgium 5: Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey; Source Info: May2006, Vol. 80 Issue 10, p15; Subject Term: RESPIRATORY syncytial virus; Subject Term: T cells; Subject Term: ANTIGENS; Subject Term: DENDRITIC cells; Subject Term: THYMIDINE; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.80.10.5032-5040.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salazar, Edith L.
AU - Calzada, Leobardo
T1 - Endometrium estradiol receptors type I and type II during early pregnancy of rat
JO - Life Sciences
JF - Life Sciences
Y1 - 2006/05/15/
VL - 78
IS - 25
M3 - Article
SP - 2919
EP - 2922
SN - 00243205
AB - Abstract: By centrifugation in a sucrose density gradient we studied the citosol 17β-estradiol binding sites of blastocyst receptive and non-receptive endometrial zones, as well as uterine horn endometrium whose ovary was extirpated three weeks before pregnancy. The cytosol was prelabelled with {3H}-17β-estradiol 2 and 25 nM. In this work two incubation temperatures were studied. On the other hand, at 4 °C unoccupied receptors were identified as different from the classic receptor 8S type I. At the same time, we found that 25 °C is the optimal temperature for the assay of total receptors to achieve complete exchange of {3H}-17β-estradiol by 17β-estradiol in the binding sites. In these conditions, the major component was the 4S type II receptor, mainly in the endometrium from ovariectomized uteri. Furthermore, 17β-estradiol content was determined in the total homogenized by radioimmunoassay and the results were: 1.42±0.16, 1.22±0.15 and 1.75±0.27 pmol/g wet tissue for receptive, non-receptive and ovariectomized uteri, respectively. [Copyright &y& Elsevier]
AB - Copyright of Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOMETRIUM
KW - ESTRADIOL
KW - PREGNANCY in animals
KW - RATS as laboratory animals
KW - Endometrium
KW - Estradiol receptors
KW - Rats
KW - Sucrose gradient
N1 - Accession Number: 20734069; Salazar, Edith L. 1; Email Address: dra_edith_salazar@yahoo.com.mx Calzada, Leobardo 2; Affiliation: 1: Medical Research Unit in Endocrine Disease, Medical Research Coordination, Social Security Mexican Institute (IMSS), Mexico 2: Health Center (T-III) Dr. Manuel Escontria, Sanitary Jurisdiction Alvaro Obregon of the Public Health Service of Distrito Federal, Mexico; Source Info: May2006, Vol. 78 Issue 25, p2919; Subject Term: ENDOMETRIUM; Subject Term: ESTRADIOL; Subject Term: PREGNANCY in animals; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: Endometrium; Author-Supplied Keyword: Estradiol receptors; Author-Supplied Keyword: Rats; Author-Supplied Keyword: Sucrose gradient; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.lfs.2005.11.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20734069&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Little, Alvin R.
AU - Sriram, Krishnan
AU - O’Callaghan, James P.
T1 - Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2006/05/15/
VL - 399
IS - 1/2
M3 - Article
SP - 162
EP - 166
SN - 03043940
AB - Abstract: Expression of the chemokine (C–C motif) ligand 2 (CCL2), also known as, monocyte chemoattractant protein (MCP)-1, increases in response to disease-, trauma-, or toxicant-induced damage to the central nervous system (CNS). In the periphery, endogenous and exogenous glucocorticoids are known to suppress CCL2 expression associated with inflammatory conditions. However, such actions of glucocorticoids on CCL2 expression in the CNS remain unknown. Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats. An immunosuppressive regimen of CORT did not alter the mRNA expression of CCL2 or its receptors in the hippocampus. ADX, however, markedly increased the expression of CCL2 and CCR2 mRNAs in the hippocampus, while CORT replacement reversed the effects of ADX on CCL2 gene expression. Hippocampal damage resulting from systemic administration of the organometallic neurotoxicant, TMT, was associated with microglial activation, as evidenced by enhanced expression of microglial markers integrin αM (CD11b) and F4/80, as well as, microglia-associated factors, CCL2 and IL-1α. An immunosuppressive dose of CORT, suppressed TMT-induced expression of CCL2. Given the association of CCL2 with microglial activation, it appears that CORT may play a role in regulating microglial activation. However, CORT treatment did not alter TMT-mediated neuronal damage and astrogliosis. Such observations suggest that injury-related expression of microglia-associated chemokines and cytokines may subserve a role unrelated to neuronal damage. In summary, our data indicate that in the CNS, CCL2 gene expression is under negative regulation by glucocorticoids. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORTICOSTERONE
KW - CHEMOKINES
KW - MONOCYTES
KW - LIGANDS (Biochemistry)
KW - Brain
KW - CCL2
KW - Corticosterone
KW - Glucocorticoids
KW - MCP-1
KW - Microglia
KW - Neurodegeneration
KW - Neuroinflammation
KW - Trimethyltin
N1 - Accession Number: 20557332; Little, Alvin R. 1 Sriram, Krishnan 1 O’Callaghan, James P.; Email Address: jdo5@cdc.gov; Affiliation: 1: Molecular Neurotoxicology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (CDC-NIOSH), TMBB-HELD, MS 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: May2006, Vol. 399 Issue 1/2, p162; Subject Term: CORTICOSTERONE; Subject Term: CHEMOKINES; Subject Term: MONOCYTES; Subject Term: LIGANDS (Biochemistry); Author-Supplied Keyword: Brain; Author-Supplied Keyword: CCL2; Author-Supplied Keyword: Corticosterone; Author-Supplied Keyword: Glucocorticoids; Author-Supplied Keyword: MCP-1; Author-Supplied Keyword: Microglia; Author-Supplied Keyword: Neurodegeneration; Author-Supplied Keyword: Neuroinflammation; Author-Supplied Keyword: Trimethyltin; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.neulet.2006.01.050
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20557332&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cowan, Lisa
AU - Esteban, Emilio
AU - McElroy-Hart, Rebecca
AU - Kieszak, Stephanie
AU - Meyer, Pamela A.
AU - Rosales, Cecilia
AU - Applegate, Martha
AU - Mada Vélez, Gerardo
AU - Arias-Ortiz, Javier
AU - Rubin, Carol
T1 - Binational study of pediatric blood lead levels along the United States/Mexico border
JO - International Journal of Hygiene & Environmental Health
JF - International Journal of Hygiene & Environmental Health
Y1 - 2006/05/16/
VL - 209
IS - 3
M3 - Article
SP - 235
EP - 240
SN - 14384639
AB - Abstract: To evaluate lead exposure among children living in border communities, the states of Arizona and New Mexico in the United States (US), and the states of Sonora and Chihuahua in Mexico collaboratively requested that the Centers for Disease Control and Prevention (CDC) provide technical assistance to document pediatric blood lead levels (BLLs) in children living along this part of the US/Mexico border. Two studies were conducted to evaluate BLLs of children aged 1–6 years. In 1998, 1210 children were tested in the Arizona/Sonora study; in 1999, 874 children were tested in New Mexico/Chihuahua. Overall geometric mean BLL was 32.5μg/l (95% Confidence Interval 31.5–33.5) with BLLs ranging from below limit of detection to 320.0μg/l. Mean BLLs were higher among children living on the Mexican side of the border (43.2μg/l) compared to those on the US side (22.3μg/l). Mean BLLs ranged from 14.9 to 31.2μg/l at the US sites and from 26.9 to 55.2μg/l at the Mexican sites. This study used a convenience sample and cannot be considered representative of the general population. Nonetheless, the range of mean BLLs among the sites and especially the higher mean BLLs among children living in the border communities in Mexico suggests different exposures to lead and warrants further attention. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Hygiene & Environmental Health is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAD poisoning in children
KW - LEAD -- Toxicology
KW - LEAD poisoning
KW - UNITED States
KW - Bi-national study
KW - Childhood lead poisoning
KW - Hispanic children
KW - Pediatric blood lead levels
KW - US/Mexico border
N1 - Accession Number: 20560521; Cowan, Lisa 1 Esteban, Emilio 2 McElroy-Hart, Rebecca 1 Kieszak, Stephanie 1 Meyer, Pamela A. 3 Rosales, Cecilia 4 Applegate, Martha 5 Mada Vélez, Gerardo 6 Arias-Ortiz, Javier 7 Rubin, Carol 1; Email Address: crubin@cdc.gov; Affiliation: 1: Health Studies Branch, Division of Environmental Hazards and Health Effects, MS-F-46, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA 2: Western Laboratory, Office of Public Health Service, Food and Safety Inspection Service, US Department of Agriculture, Alameda, CA, USA 3: Lead Poisoning Prevention Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA 4: Office of Border Health, Arizona Department of Health Services, Tucson, AZ, USA 5: New Mexico Childhood Lead Poisoning Prevention Program, Office of Epidemiology, New Mexico Department of Health, Santa Fe, NM, USA 6: Oficina de Epidemiología, Dirección General de Servicios de Salud, Secretaría de Salud Pública de Sonora, Hermosillo, Sonora, México 7: Oficina de Epidemiología, Secretaría de Salud Pública de Chihuahua, Chihuahua, México; Source Info: May2006, Vol. 209 Issue 3, p235; Subject Term: LEAD poisoning in children; Subject Term: LEAD -- Toxicology; Subject Term: LEAD poisoning; Subject Term: UNITED States; Author-Supplied Keyword: Bi-national study; Author-Supplied Keyword: Childhood lead poisoning; Author-Supplied Keyword: Hispanic children; Author-Supplied Keyword: Pediatric blood lead levels; Author-Supplied Keyword: US/Mexico border; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijheh.2005.12.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20560521&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Felicia B.
AU - Sander, Lane C.
AU - Wise, Stephen A.
AU - Girard, James
T1 - Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/05/19/
VL - 1115
IS - 1/2
M3 - Article
SP - 93
EP - 102
SN - 00219673
AB - Abstract: Several major constituents in St. John''s wort were determined for a homogenized plant sample. Three extraction techniques were evaluated: Soxhlet extraction, pressurized-fluid extraction (PFE), and sonication extraction. Levels of nine constituents (chlorogenic acid, rutin, hyperoside, isoquercitrin, quercitrin, quercetin, amentoflavone, pseudohypericin, and hypericin) were measured using liquid chromatography with ultraviolet/visible absorbance, mass spectrometric, and fluorescence detection. Levels of total naphthodianthrones determined by liquid chromatography (LC) with absorbance detection at 590nm were compared with levels determined by direct spectrophotometry at the same wavelength. Additionally, the methods described in this paper were applied to several brands of St. John''s wort finished products. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Extraction techniques
KW - Liquid chromatography
KW - Hypericum
KW - Flavonoids
KW - Absorbance detection
KW - Fluorescence detection
KW - Hypericin
KW - Mass spectrometry
KW - Pressurized fluid extraction
KW - Pseudohypericin
KW - Sonication
KW - Soxhlet extraction
KW - St. John's wort
N1 - Accession Number: 20623393; Williams, Felicia B. 1,2,3; Sander, Lane C. 1; Email Address: lane.sander@nist.gov; Wise, Stephen A. 1; Girard, James 2; Affiliations: 1: National Institute of Standards and Technology, Gaithersburg, MD 20899, USA 1; 2: American University, Washington, DC 20016, USA; 3: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; Issue Info: May2006, Vol. 1115 Issue 1/2, p93; Thesaurus Term: Extraction techniques; Thesaurus Term: Liquid chromatography; Thesaurus Term: Hypericum; Subject Term: Flavonoids; Author-Supplied Keyword: Absorbance detection; Author-Supplied Keyword: Fluorescence detection; Author-Supplied Keyword: Hypericin; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Pressurized fluid extraction; Author-Supplied Keyword: Pseudohypericin; Author-Supplied Keyword: Sonication; Author-Supplied Keyword: Soxhlet extraction; Author-Supplied Keyword: St. John's wort; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chroma.2006.02.078
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Li, Hui
AU - Kijak, Philip James
AU - Turnipseed, Sherri B.
AU - Cui, Wei
T1 - Analysis of veterinary drug residues in shrimp: A multi-class method by liquid chromatography–quadrupole ion trap mass spectrometry
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/05/19/
VL - 836
IS - 1/2
M3 - Article
SP - 22
EP - 38
SN - 15700232
AB - Abstract: A liquid chromatography–mass spectrometry (LC–MS) method was developed to screen and confirm veterinary drug residues in raw shrimp meat. This method simultaneously monitors 18 drugs of different classes, including oxytetracycline (OTC), sulfonamides, quinolones, cationic dyes, and toltrazuril sulfone (TOLS). The homogenized shrimp meat is extracted with 5% trichloroacetic acid. The extract is further cleaned using polymer-based SPE. A 50mm phenyl column separates the analytes, prior to analysis with an ion trap mass spectrometer interfaced with an atmospheric pressure chemical ionization source. This method is able to confirm oxytetracycline residues at 200ng/g, toltrazuril sulfone at 50ng/g, sulfaquinoxaline at 20ng/g, and the other 15 drugs at 10ng/g or lower levels. An estimate of the level of residues can also be made so that only confirmed samples above action levels will be sent for quantitation. The method is validated with both fortified and incurred samples, using multiple shrimp species as well. This multi-class method can provide a means to simultaneously monitor for a wide range of illegal drug residues in shrimp. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY drugs
KW - LIQUID chromatography
KW - MASS spectrometry
KW - SULFONAMIDES
KW - BASIC dyes
KW - Cationic dye
KW - Confirmatory
KW - Fluoroquinolone
KW - High throughput
KW - Multi-class
KW - Multi-residue
KW - Oxytetracycline
KW - Quinolone
KW - Shrimp
KW - Sulfonamide
KW - Toltrazuril sulfone
KW - Veterinary drug
N1 - Accession Number: 20822294; Li, Hui 1 Kijak, Philip James 1; Email Address: Philip.Kijak@fda.gov Turnipseed, Sherri B. 2 Cui, Wei 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD 20708, USA 2: U.S. Food and Drug Administration, Animal Drug Research Center, Denver, CO 80225, USA; Source Info: May2006, Vol. 836 Issue 1/2, p22; Subject Term: VETERINARY drugs; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: SULFONAMIDES; Subject Term: BASIC dyes; Author-Supplied Keyword: Cationic dye; Author-Supplied Keyword: Confirmatory; Author-Supplied Keyword: Fluoroquinolone; Author-Supplied Keyword: High throughput; Author-Supplied Keyword: Multi-class; Author-Supplied Keyword: Multi-residue; Author-Supplied Keyword: Oxytetracycline; Author-Supplied Keyword: Quinolone; Author-Supplied Keyword: Shrimp; Author-Supplied Keyword: Sulfonamide; Author-Supplied Keyword: Toltrazuril sulfone; Author-Supplied Keyword: Veterinary drug; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.03.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Rickie R.
T1 - Acoustic measurement: A tutorial for molecular biologists
JO - Brain Research
JF - Brain Research
Y1 - 2006/05/26/
VL - 1091
IS - 1
M3 - Article
SP - 32
EP - 39
SN - 00068993
AB - Abstract: Although skilled in in vitro techniques, the molecular biologist may not understand the finer points of acoustical measurement. Measurement is necessary whenever the auditory system function is being measured using the auditory brainstem response (ABR) or distortion product otoacoustic emissions (DPOAE) or is being challenged by a noise exposure. While the theory of measuring an acoustic signal with a calibrated measuring microphone is simple, in practice, it can become complex. The present article presents guidelines for measuring acoustic stimuli which is within the abilities of a well equipped laboratory. It also presents a set of links for further information and some sources for procurement of equipment. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUDITORY pathways
KW - OTOACOUSTIC emissions
KW - BIOACOUSTICS
KW - MOLECULAR biologists
KW - BRAIN stem
KW - ABR
KW - Acoustic measurement
KW - Auditory system
KW - DPOAE
KW - Mouse
N1 - Accession Number: 21495007; Davis, Rickie R. 1; Email Address: rrd1@cdc.gov; Affiliation: 1: Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: May2006, Vol. 1091 Issue 1, p32; Subject Term: AUDITORY pathways; Subject Term: OTOACOUSTIC emissions; Subject Term: BIOACOUSTICS; Subject Term: MOLECULAR biologists; Subject Term: BRAIN stem; Author-Supplied Keyword: ABR; Author-Supplied Keyword: Acoustic measurement; Author-Supplied Keyword: Auditory system; Author-Supplied Keyword: DPOAE; Author-Supplied Keyword: Mouse; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.brainres.2006.02.130
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malarkey, M.
AU - Solomon, R.
AU - Witten, C.
AU - Blomm, E.
AU - Wells, M.
AU - Braun, M.
AU - Wise, R.
AU - Zinderman, C.
AU - Jernigan, D. B.
AU - Kuehnert, M. J.
AU - Srinivasan, A.
AU - Wang, S.
T1 - Investigation into Recalled Human Tissue for Transplantation -- United States, 2005-2006.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2006/05/26/
VL - 55
IS - 20
M3 - Article
SP - 564
EP - 566
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - Reports on the ongoing investigation by the U.S. Food & Drug Administration regarding a recall for human tissues recovered by Biomedical Tissue Services (BTS) as of May 2006. Inaccuracies in donor records; Violations of the Current Good Tissue Practice Rules; Number tissue processors which recalled all products that had been produced from BTS tissues.
KW - TISSUES
KW - ORGAN donors
KW - RULES
KW - PRODUCT recall
KW - UNITED States
KW - BIOMEDICAL Tissue Services Ltd.
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 20982963; Malarkey, M. 1 Solomon, R. 1 Witten, C. 1 Blomm, E. 1 Wells, M. 1 Braun, M. 1 Wise, R. 1 Zinderman, C. 1 Jernigan, D. B. 2 Kuehnert, M. J. 2 Srinivasan, A. 2 Wang, S. 3; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration 2: Div of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases 3: EIS Officer, CDC; Source Info: 5/26/2006, Vol. 55 Issue 20, p564; Subject Term: TISSUES; Subject Term: ORGAN donors; Subject Term: RULES; Subject Term: PRODUCT recall; Subject Term: UNITED States; Company/Entity: BIOMEDICAL Tissue Services Ltd. Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Knippen, Maureen A.
T1 - Transfusion-Related Acute Lung Injury.
JO - American Journal of Nursing
JF - American Journal of Nursing
Y1 - 2006/06//
VL - 106
IS - 6
M3 - Article
SP - 61
EP - 64
SN - 0002936X
AB - The article discusses transfusion-related acute lung injury (TRALI), a potentially lethal result of allergenic blood transfusion. TRALI has been linked with transfusion of all types of plasma-containing blood products. Symptoms usually appear within two hours but nearly always within six hours of transfusion. There are two hypotheses that may explain the etiology of TRALI: the immune-mediated response and the two-hit neutrophil-priming mechanism. Finally, early identification of TRALI can be critical to patients' survival.
KW - LUNGS -- Wounds & injuries
KW - BLOOD transfusion -- Complications
KW - DISEASES -- Causes & theories of causation
KW - SYMPTOMS
KW - DIAGNOSIS
N1 - Accession Number: 21211110; Knippen, Maureen A. 1; Email Address: maureen.knippen@fda.hhs.gov; Affiliation: 1: Consumer Safety Officer, Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD; Source Info: Jun2006, Vol. 106 Issue 6, p61; Subject Term: LUNGS -- Wounds & injuries; Subject Term: BLOOD transfusion -- Complications; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: SYMPTOMS; Subject Term: DIAGNOSIS; Number of Pages: 4p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106307278
T1 - Emergency. Transfusion-related acute lung injury.
AU - Knippen MA
Y1 - 2006/06//
N1 - Accession Number: 106307278. Language: English. Entry Date: 20060721. Revision Date: 20150819. Publication Type: Journal Article; case study; diagnostic images. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Acute Lung Injury, Transfusion-Related -- Etiology
KW - Blood Transfusion -- Adverse Effects
KW - Acute Lung Injury, Transfusion-Related -- Physiopathology
KW - Acute Lung Injury, Transfusion-Related -- Symptoms
KW - Adult
KW - Blood Donors
KW - Blood Transfusion -- Nursing
KW - Female
KW - HLA Antigens -- Blood
KW - Middle Age
KW - Monitoring, Physiologic
KW - Nursing Assessment
SP - 61
EP - 64
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 106
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - A rare but potentially lethal result of allogeneic blood transfusion, TRALI resembles acute respirtory distress syndrome. Early intervention can save lives.
SN - 0002-936X
AD - Consumer Safety Officer, Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Summan, Mukesh
AU - Warren, Gordon L.
AU - Mercer, Robert R.
AU - Chapman, Rebecca
AU - Hulderman, Tracy
AU - Van Rooijen, Nico
AU - Simeonov, Petia P.
T1 - Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study.
JO - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
JF - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
Y1 - 2006/06//
VL - 59
IS - 6
M3 - Article
SP - R1488
EP - R1495
SN - 03636119
AB - The study evaluates the influence of monocytes/macrophages in the mechanisms of skeletal muscle injury using a mouse model and selective depletion of peripheral monocyte with systemic injections of liposomal clodronate (dichloromethylene bisphosphonate). This pharmacological treatment has been demonstrated to induce specific apoptotic death in monocytes and phagocytic macrophages. In the current studies, the liposomal clodronate injections resulted in a marked attenuation of the peak inflammatory response in the freeze-injured muscle in the first three days after injury. The effect was accompanied by a transient reduction (at day 1 or 3 postinjury) of the expression of several genes coding for inflammatory, as well as growth-related mediators, including TNF, monocyte chemoattractant protein (MCP)-1, thioredoxin, high-mobility group AT-hook 1, insulin-like growth factor-binding protein (IGFBP), and IGF-1. In contrast, the expression of major myogenic factors (i.e., MyoD and myogenin) directly involved in the activation/proliferation and differentiation of muscle precursor cells was not altered by the clodronate liposome treatment. The repair process in the injured muscle of clodronate liposome-treated mice was characterized by prolonged clearance of necrotic myofibers and a tendency for increased muscle fat accumulation at day 9 and 14 postinjury, respectively. In conclusion, a significant reduction of the initial monocyte/macrophage influx into the injured muscle is associated with not improved, but moderately impaired, repair processes after skeletal muscle injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Regulatory, Integrative & Comparative Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCYTES
KW - MACROPHAGES
KW - BONE resorption
KW - THERAPEUTICS
KW - INFLAMMATION
KW - CARRIER proteins
KW - PHAGOCYTES
KW - gene expression
KW - inflammation
KW - myogenesis
KW - skeletal muscle injury
N1 - Accession Number: 21089903; Summan, Mukesh 1 Warren, Gordon L. 2 Mercer, Robert R. 1 Chapman, Rebecca 1 Hulderman, Tracy Van Rooijen, Nico 3 Simeonov, Petia P. 1; Email Address: PSimeonova@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Department of Physical Therapy, Georgia State University, Atlanta, Georgia 3: Department of Molecular Cell Biology, Vrije University, Amsterdam, Netherlands; Source Info: Jun2006, Vol. 59 Issue 6, pR1488; Subject Term: MONOCYTES; Subject Term: MACROPHAGES; Subject Term: BONE resorption; Subject Term: THERAPEUTICS; Subject Term: INFLAMMATION; Subject Term: CARRIER proteins; Subject Term: PHAGOCYTES; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: myogenesis; Author-Supplied Keyword: skeletal muscle injury; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
L3 - 10.1152/ajpregu.00465.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106309294
T1 - Longitudinal relationships between use of highly active antiretroviral therapy and satisfaction with care among women living with HIV/AIDS.
AU - Burke-Miller JK
AU - Cook JA
AU - Cohen MH
AU - Hessol NA
AU - Wilson TE
AU - Richardson JL
AU - Williams P
AU - Gange SJ
Y1 - 2006/06//
N1 - Accession Number: 106309294. Language: English. Entry Date: 20060728. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D); RAND Patient Satisfaction Questionnaire, Short Form (PSQ-18); Medical Outcomes Study HIV Instrument. Grant Information: National Instititute of Allergy and Infectious Diseases with supplemental funding from the National Cancer Institute and the National Institute on Drug Abuse (grants UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590), the National Institute of Child Health and Human Development (grant UO1-CH-32632) and the National Center for Research Resources (grants MO1-RR-00071, MO1-RR-00079, and MO1-RR-00083). NLM UID: 1254074.
KW - Antiviral Agents -- Therapeutic Use
KW - HIV Infections -- Psychosocial Factors
KW - Patient Satisfaction
KW - Treatment Outcomes
KW - Women's Health -- Psychosocial Factors
KW - Adult
KW - Attitude Measures
KW - Center for Epidemiological Studies Depression Scale
KW - Correlation Coefficient
KW - Data Analysis Software
KW - Depression -- Symptoms
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Health Services Accessibility
KW - Health Status Indicators
KW - Insurance, Health
KW - Medical Care
KW - Mental Health
KW - Multiple Logistic Regression
KW - Multiple Regression
KW - Multivariate Analysis
KW - Odds Ratio
KW - P-Value
KW - Primary Health Care -- Utilization
KW - Prospective Studies
KW - Psychological Tests
KW - Quality of Life
KW - Race Factors
KW - Reliability and Validity
KW - Repeated Measures
KW - Substance Abuse
KW - United States
KW - Univariate Statistics
KW - Human
SP - 1044
EP - 1051
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 96
IS - 6
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We used longitudinal data to examine the roles of 4 dimensions of patient satisfaction as both predictors and outcomes of use of highly active antiretroviral therapy (HAART) among women in the United States with HIV/AIDS. METHODS: Generalized estimating equations were used to analyze time-lagged satisfaction-HAART relationships over 8 years in the Women's Interagency HIV Study. RESULTS: Multivariate models showed that, over time, HAART use was associated with higher patient satisfaction with care in general, with providers, and with access/convenience of care; however, patient satisfaction was not associated with subsequent HAART use. Symptoms of depression and poor health-related quality of life were associated with less satisfaction with care on all 4 dimensions assessed, whereas African American race/ethnicity, illegal drug use, and fewer primary care visits were associated with less HAART use. CONCLUSIONS: Our findings suggest that dissatisfaction with care is not a reason for underuse of HAART among women with HIV and that providers should not be discouraged from recommending HAART to dissatisfied patients. Rather, increasing women's access to primary care could result in both increased HAART use and greater patient satisfaction.
SN - 0090-0036
AD - Center on Mental Health Services Research and Policy, University of Illinois at Chicago, 104 S Michigan Ave, Suite 900, Chicago, IL 60603. jburke@psych.uic.edu.
U2 - PMID: 16670232.
DO - 10.2105/AJPH.2005.061929
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gilbert, R.
AU - Tan, H. K.
AU - Cliffe, S.
AU - Guy, E.
AU - Stanford, M.
T1 - Symptomatic toxoplasma infection due to congenital and postnatally acquired infection.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2006/06//
VL - 91
IS - 6
M3 - Article
SP - 495
EP - 498
SN - 00039888
AB - Aims: To determine the incidence and severity of symptomatic toxoplasma infection presenting during childhood due to congenital or postnatally acquired infection. Methods: Between 2002 and 2004, newly diagnosed children (<16 years) with signs or symptoms of congenital or ocular toxoplasmosis were reported by clinicians to the British Paediatric and Ophthalmic Surveillance Units or by toxoplasma referral laboratories. Confirmed cases were estimated to have a greater than 50% probability of congenital and/or ocular toxoplasmosis, based on clinical and serological findings. Results: Thirty eight children had confirmed toxoplasma infection. Twenty two (58%) were classified with congenital infection (cumulative incidence for England and Wales 3.4/100 000 live births; 95% CI 2.4 to 4.8), of whom 2 (9%) were stillborn, 7 (32%) live births had intracranial abnormalities and/or developmental delay (5 of whom had retinochoroiditis), and 10 (45%) had retinochoroiditis with no other abnormalities reported. A further 16 (42%) children were classified as infected after birth; all had retinochoroiditis. Conclusions: The low burden of symptomatic congenital toxoplasmosis combined with the lack of evidence of an effective treatment support current policy not to offer prenatal or neonatal screening for toxoplasma infection. Primary prevention strategies need to address acquisition of infection in childhood which accounts for half the ocular disease due to toxoplasma infection in children in the UK and Ireland. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXOPLASMOSIS
KW - CONGENITAL toxoplasmosis
KW - INFECTION in children
KW - TOXOPLASMA
KW - PREVENTIVE medicine
KW - GREAT Britain
N1 - Accession Number: 21134960; Gilbert, R. 1; Email Address: ruth.gilbert@ich.ucl.ac.uk Tan, H. K. 1 Cliffe, S. 1 Guy, E. 2 Stanford, M. 3; Affiliation: 1: Centre for Paediatric Epidemiology and Biostotistics, Institute of Child Health, London, UK 2: Toxoplasma Reference Unit, National Public Health Service for Wales, Swansea, UK 3: Department of Ophthalmology, St Thomas' Hospital, London, UK; Source Info: Jun2006, Vol. 91 Issue 6, p495; Subject Term: TOXOPLASMOSIS; Subject Term: CONGENITAL toxoplasmosis; Subject Term: INFECTION in children; Subject Term: TOXOPLASMA; Subject Term: PREVENTIVE medicine; Subject Term: GREAT Britain; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1136/adc.2005.088385
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106339138
T1 - Subjective symptoms among female hospital nurses in Korea.
AU - Smith DR
AU - Choe M
AU - Chae Y
AU - An G
AU - Jeong J
AU - Jeon M
Y1 - 2006/06//2006 Jun
N1 - Accession Number: 106339138. Language: English. Entry Date: 20060929. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Asia; Nursing; Peer Reviewed.
KW - Depression
KW - Dysmenorrhea
KW - Nurses -- Korea
KW - Occupational Health
KW - Premenstrual Syndrome
KW - Adult
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Fatigue
KW - Female
KW - Hospitals
KW - Korea
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - Questionnaires
KW - Scales
KW - Self Report
KW - Human
SP - 78
EP - 83
JO - Asian Journal of Nursing
JF - Asian Journal of Nursing
JA - ASIAN J NURS
VL - 9
IS - 2
PB - Scientific Communications International Ltd.
AB - Aim: To investigate the prevalence, distribution, and correlates of subjective symptoms among a cross-sectional sample of female hospital nurses in Korea.Methods: A self-reporting survey was administered to a cross-sectional sample of 337 nurses from a Korean teaching hospital This survey focused on subjective symptoms, physiological workplace factors, and psychosocial issues. Correlations between subjective symptoms and demographic or workplace items were evaluated using a multiple logistic regression model.Results: Acceptable questionnaires were received by 299 of the 337 nurses (88.7%). The prevalence of subjective symptoms varied, with depression reported as: never (24.5%), sometimes (73.2%), and always (2.3%). Dysmenorrhoea was reported as: never (18.7%), sometimes (46.8%), and always (34.5%). Premenstrual tension was reported as: never affected (22.1%), sometimes affected (43.8%), and always affected (34.1%). Logistic regression analysis indicated that nurses who had children were only one fifth as likely to report dysmenorrhoea as those without children (odds ratio, 0.2; 95% confidence interval 0.05-0.7; p = 0.0138). A similar relationship was also demonstrated for premenstrual tension (odds ratio, 0.2; 95% confidence interval, 0.05-0.7; p = 0.0158).Conclusions: The results suggest that subjective symptoms constitute an important source of occupational morbidity for Korean nurses. Further interventional studies need to be undertaken to effectively target the resources for this sped Asian population.
SN - 1818-6270
AD - International Center for Research Promotion and Informatics, Japan National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan; smith@niih.go.jp
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ferguson, Sherry A.
AU - Siitonen, Paul H.
AU - Cisneros, F. Javier
AU - Gough, Bobby
AU - Young, John F.
T1 - Steady State Pharmacokinetics of Oral Treatment with 13-cis-Retinoic Acid or all-trans-Retinoic Acid in Male and Female Adult Rats.
JO - Basic & Clinical Pharmacology & Toxicology
JF - Basic & Clinical Pharmacology & Toxicology
Y1 - 2006/06//
VL - 98
IS - 6
M3 - Article
SP - 582
EP - 587
PB - Wiley-Blackwell
SN - 17427835
AB - Male and female Sprague-Dawley rats were orally gavaged with 13-cis-retinoic acid (7.5 or 15 mg/kg) or all-trans-retinoic acid (10 or 15 mg/kg) for 7 consecutive days. Blood was collected out to 8 hr after the last gavage on day 7. HPLC serum concentrations of 13-cis-retinoic acid, all-trans-retinoic acid, and 13-cis-4-oxo-retinoic acid were subjected to model independent pharmacokinetic analyses. Peak serum levels of 563 to 1640 ng/ml were observed for rats treated with 13-cis-retinoic acid at 1.5–2 hr after gavage. Peak serum levels of 183 to 267 ng/ml at 1.5 hr after gavage were observed for all-trans-retinoic acids. The elimination half-life of 13-cis-retinoic acid was about 1.5 hr while the elimination half-life of all-trans-retinoic acid was slightly longer. There were no sex differences for any parameter. Serum levels resulting from the 7.5 mg/kg 13-cis-retinoic acid were similar to those of human Accutane® users. [ABSTRACT FROM AUTHOR]
AB - Copyright of Basic & Clinical Pharmacology & Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRETINOIN
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
KW - BLOOD plasma
KW - SERUM
KW - RATS
N1 - Accession Number: 20858028; Ferguson, Sherry A. 1; Email Address: sferguson@nctr.fda.gov Siitonen, Paul H. 1 Cisneros, F. Javier 2 Gough, Bobby 2 Young, John F. 3; Affiliation: 1: Division of Biochemical Toxicology 2: Division of Neurotoxicology 3: Division of Biometry & Risk Assessment, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079-9502, U.S.A.; Source Info: Jun2006, Vol. 98 Issue 6, p582; Subject Term: TRETINOIN; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Subject Term: BLOOD plasma; Subject Term: SERUM; Subject Term: RATS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1742-7843.2006.pto_359.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ai Gao
AU - Bing-Ci Liu
AU - Xiang-Lin Shi
AU - Chuan-Shu Huang
AU - Xiao-Wei Jia
AU - Bao-Rong You
AU - Meng Ye
AU - Fu-Hai Shen
AU - Hong-Ju Du
T1 - Vitamin C Inhibits Benzo[a]pyrene-Induced Cell Cycle Changes Partly via Cyclin D1/E2F Pathway in Human Embryo Lung Fibroblasts.
JO - Biomedical & Environmental Sciences
JF - Biomedical & Environmental Sciences
Y1 - 2006/06//
VL - 19
IS - 3
M3 - Article
SP - 239
EP - 244
SN - 08953988
AB - Objective To study the molecular mechanism of the inhibitory effects of vitamin C on benzo[a]pyrene (B[a]P)-induced changes of cell cycle in human embryo lung fibroblast (HELF) cells. Methods The stable transfectants, HELF transfected with antisense cyclin D1 and antisense CDK4, were established. Cells were cultured and pretreated with vitamin C before stimulation with B[a]P for 24 h. The expression levels of cyclin D1, CDK4, E2F1, and E2F4 were determined by Western blot. Flow cytometric analysis was employed to detect the distributions of cell cycle. Results B[a]P significantly elevated the expression levels of cyclin D1, E2F1, and E2F4 in HELF cells. Vitamin C decreased the expression levels of cyclin D1, E2F1, and E2F4 in B[a]P-stimulated HELF cells. Dose-dependent relationships were not found between the different concentrations of vitamin C (10, 100, 500, 1000, and 5000 μmol/L) and the expression levels of cyclin D1, E2F1, and E2F4 in HELF cells. The expression levels of cyclin D1, E2F1, and E2F4 in B[a]P-treated transfectants were lower than those in B[a]P-treated HELF cells. The expression levels of cyclin D1 and E2F4 treated with vitamin C and antisense cyclin D1 were decreased compared with those treated with antisense cyclin D1 alone. The effects of vitamin C combined with antisense CDK4 on the expression levels of cyclin D1 and E2F1/E2F4 were similar to those of antisense CDK4 alone. B[a]P progressed HELF cells from G1 to S phase. Both vitamin C and antisense cyclin D1 suppressed the changes of cell cycle progressed by B[a]P. However, antisense CDK4 did not attenuate the above changes. Vitamin C combined with antisense CDK4 markedly suppressed B[a]P-induced changes of cell cycle as compared with antisense CDK4. But the inhibitory effects of vitamin C combined with antisense cyclin D1 on B[a]P-induced changes of cell cycle were similar to those of vitamin C alone or antisense cyclin D1 alone. Conclusions B[a]P progressed HELF cells from G1 to S phase via intracellular signaling pathway of cyclin D1/E2F. Vitamin C may modulate this signaling pathway to protect cells from injury caused by B[a]P. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biomedical & Environmental Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytometry
KW - Biological rhythms
KW - Vitamin C
KW - Cell cycle
KW - Fibroblasts
KW - Cell proliferation
KW - Connective tissue cells
KW - Western immunoblotting
KW - Proteins -- Analysis
KW - Antisense
KW - Ascorbic acid
KW - B[a]P
KW - Cyclin D1
KW - E2F
N1 - Accession Number: 22193795; Ai Gao 1; Bing-Ci Liu 1; Email Address: bcliu@263.net; Xiang-Lin Shi 2; Chuan-Shu Huang 3; Xiao-Wei Jia 1; Bao-Rong You 1; Meng Ye 1; Fu-Hai Shen 1; Hong-Ju Du 1; Affiliations: 1: National Institute of Occupation Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.; 2: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26506, USA.; 3: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987.; Issue Info: Jun2006, Vol. 19 Issue 3, p239; Thesaurus Term: Cytometry; Thesaurus Term: Biological rhythms; Subject Term: Vitamin C; Subject Term: Cell cycle; Subject Term: Fibroblasts; Subject Term: Cell proliferation; Subject Term: Connective tissue cells; Subject Term: Western immunoblotting; Subject Term: Proteins -- Analysis; Author-Supplied Keyword: Antisense; Author-Supplied Keyword: Ascorbic acid; Author-Supplied Keyword: B[a]P; Author-Supplied Keyword: Cyclin D1; Author-Supplied Keyword: E2F; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hnizdo, Eva
AU - Glindmeyer, Henry
AU - Petsonk, Edward
AU - Enright, Paul
AU - Buist, A. Sonia
T1 - Case Definitions for Chronic Obstructive Pulmonary Disease.
JO - COPD: Journal of Chronic Obstructive Pulmonary Disease
JF - COPD: Journal of Chronic Obstructive Pulmonary Disease
Y1 - 2006/06//
VL - 3
IS - 2
M3 - Article
SP - 95
EP - 100
SN - 15412555
AB - The objective of this study was to evaluate the definitions for classification of chronic obstructive pulmonary disease (COPD) recommended by the American Thoracic Society (ATS) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Using data from the U.S. population-based third National Health and Nutrition Examination Survey (NHANES III), we compared the number of individuals in the U.S. population who met definitions of airflow obstruction based on the fixed ratio of FEV 1 / FVC [ABSTRACT FROM AUTHOR]
AB - Copyright of COPD: Journal of Chronic Obstructive Pulmonary Disease is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases
KW - MEDICAL societies
KW - AIRWAY (Medicine)
KW - CLASSIFICATION
KW - HEALTH surveys
KW - UNITED States
KW - Airflow obstruction
KW - COPD definition
KW - Diagnosis of COPD
KW - Diagnosis of COPD.
KW - Epidemiology
N1 - Accession Number: 20750643; Hnizdo, Eva 1; Email Address: ehnizdo@cdc.gov Glindmeyer, Henry 1; Email Address: hglindmeyer@gmail.com Petsonk, Edward 2; Email Address: elp2@cdc.gov Enright, Paul 3; Email Address: lungguy@aol.com Buist, A. Sonia 4; Email Address: buists@ohsu.edu; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, 26505, USA 2: Section of Pulmonary, Critical Care, and Environmental Medicine, Department of Medicine, Tulane Medical School, New Orleans, Louisiana, 70112, USA 3: The University of Arizona, Tucson, Arizona, 85718, USA 4: Pulmonary & Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, 97239-3098, USA; Source Info: 2006, Vol. 3 Issue 2, p95; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: MEDICAL societies; Subject Term: AIRWAY (Medicine); Subject Term: CLASSIFICATION; Subject Term: HEALTH surveys; Subject Term: UNITED States; Author-Supplied Keyword: Airflow obstruction; Author-Supplied Keyword: COPD definition; Author-Supplied Keyword: Diagnosis of COPD; Author-Supplied Keyword: Diagnosis of COPD.; Author-Supplied Keyword: Epidemiology; NAICS/Industry Codes: 813920 Professional Organizations; Number of Pages: 6p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/15412550600651552
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20750643&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barr, Dana B.
AU - Thomas, Kent
AU - Curwin, Brian
AU - Landsittel, Doug
AU - Raymer, James
AU - Chensheng Lu
AU - Donnelly, K. C.
AU - Acquavella, John
T1 - Biomonitoring of Exposure in Farmworker Studies.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/06//
VL - 114
IS - 6
M3 - Article
SP - 936
EP - 942
PB - Superintendent of Documents
SN - 00916765
AB - Although biomonitoring has been used in many occupational and environmental health and exposure studies, we are only beginning to understand the complexities and uncertainties involved with the biomonitoring process—from study design, to sample collection, to chemical analysis— and with interpreting the resulting data. We present an overview of concepts that should be considered when using biomonitoring or biomonitoring data, assess the current status of biomonitoring, and detail potential advancements in the field that may improve our ability to both collect and interpret biomonitoring data. We discuss issues such as the appropriateness of biomonitoring for a given study, the sampling time frame, temporal variability in biological measurements to nonpersistent chemicals, and the complex issues surrounding data interpretation. In addition, we provide recommendations to improve the utility of biomonitoring in farmworker studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological monitoring
KW - Poisons -- Analysis
KW - Bioindicators
KW - Industrial hygiene
KW - Environmental health
KW - Public health
KW - Environmental exposure
KW - Environmental sciences
KW - Agricultural laborers
KW - biomonitoring
KW - blood
KW - farmworker
KW - urine
N1 - Accession Number: 21183168; Barr, Dana B. 1; Email Address: dbarr@cdc.gov; Thomas, Kent 2; Curwin, Brian 3; Landsittel, Doug 4; Raymer, James 5; Chensheng Lu 6; Donnelly, K. C. 7; Acquavella, John; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2: National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 3: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA; 4: Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, Pennsylvania, USA; 5: RTI International, Research Triangle Park, North Carolina, USA; 6: Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 7: Department of Environmental and Occupational Health, Texas A&M University System Health Science Center, College Station, Texas, USA; Issue Info: Jun2006, Vol. 114 Issue 6, p936; Thesaurus Term: Biological monitoring; Thesaurus Term: Poisons -- Analysis; Thesaurus Term: Bioindicators; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Thesaurus Term: Public health; Thesaurus Term: Environmental exposure; Thesaurus Term: Environmental sciences; Thesaurus Term: Agricultural laborers; Author-Supplied Keyword: biomonitoring; Author-Supplied Keyword: blood; Author-Supplied Keyword: farmworker; Author-Supplied Keyword: urine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Document Type: Article
L3 - 10.1289/ehp.8527
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Barr, Dana B.
AU - Landsittel, Doug
AU - Nishioka, Marcia
AU - Thomas, Kent
AU - Curwin, Brian
AU - Raymer, James
AU - Donnelly, Kirby C.
AU - McCauley, Linda
AU - Ryan, P. Barry
T1 - A Survey of Laboratory and Statistical Issues Related to Farmworker Exposure Studies.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/06//
VL - 114
IS - 6
M3 - Article
SP - 961
EP - 968
PB - Superintendent of Documents
SN - 00916765
AB - Developing internally valid, and perhaps generalizable, farmworker exposure studies is a complex process that involves many statistical and laboratory considerations. Statistics are an integral component of each study beginning with the design stage and continuing to the final data analysis and interpretation. Similarly, data quality plays a significant role in the overall value of the study. Data quality can be derived from several experimental parameters including statistical design of the study and quality of environmental and biological analytical measurements. We discuss statistical and analytic issues that should be addressed in every farmworker study. These issues include study design and sample size determination, analytical methods and quality control and assurance, treatment of missing data or data below the method's limits of detection, and post-hoc analyses of data from multiple studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural sociology
KW - Experimental design
KW - Biological monitoring
KW - Poisons -- Analysis
KW - Industrial hygiene
KW - Environmental health
KW - Public health
KW - Environmental exposure
KW - Agricultural laborers
KW - analytical methodology
KW - biomarkers
KW - laboratory
KW - limit of detection
KW - omics
KW - quality control
KW - sample size
KW - statistics
N1 - Accession Number: 21183171; Barr, Dana B. 1; Email Address: dbarr@cdc.gov; Landsittel, Doug 2; Nishioka, Marcia 3; Thomas, Kent 4; Curwin, Brian 5; Raymer, James 6; Donnelly, Kirby C. 7; McCauley, Linda 8; Ryan, P. Barry 9; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2: Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, Pennsylvania, USA; 3: Battelle Memorial Institute, Columbus, Ohio, USA; 4: National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 5: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA; 6: RTI International, Research Triangle Park, North Carolina, USA; 7: Texas A&M University System Health Science Center, College Station, Texas, USA; 8: School of Human Environmental Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA; 9: Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; Issue Info: Jun2006, Vol. 114 Issue 6, p961; Thesaurus Term: Agricultural sociology; Thesaurus Term: Experimental design; Thesaurus Term: Biological monitoring; Thesaurus Term: Poisons -- Analysis; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Thesaurus Term: Public health; Thesaurus Term: Environmental exposure; Thesaurus Term: Agricultural laborers; Author-Supplied Keyword: analytical methodology; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: laboratory; Author-Supplied Keyword: limit of detection; Author-Supplied Keyword: omics; Author-Supplied Keyword: quality control; Author-Supplied Keyword: sample size; Author-Supplied Keyword: statistics; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
L3 - 10.1289/ehp.8528
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21183171&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Srinivasan, Ramaprasad
AU - Daniels, Jasmine
AU - Fusaro, Vincent
AU - Lundqvist, Andreas
AU - Killian, Jonathan K.
AU - Geho, David
AU - Quezado, Martha
AU - Kleiner, David
AU - Rucker, Sally
AU - Espina, Virginia
AU - Whiteley, Gordon
AU - Liotta, Lance
AU - Petricoin, Emmanuel
AU - Pittaluga, Stefania
AU - Hitt, Ben
AU - Barrett, A.J.
AU - Rosenblatt, Kevin
AU - Childs, Richard W.
T1 - Accurate diagnosis of acute graft-versus-host disease using serum proteomic pattern analysis
JO - Experimental Hematology
JF - Experimental Hematology
Y1 - 2006/06//
VL - 34
IS - 6
M3 - Article
SP - 796
EP - 801
SN - 0301472X
AB - Objective: The rapid diagnosis of acute graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT) is important for optimizing the management of this life-threatening complication. Current diagnostic techniques are time-consuming and require invasive tissue sampling. We investigated serum protein pattern analysis using surface-enhanced laser desorption ionization time-of-flight (SELDI-TOF) mass spectrometry as a tool to diagnose GVHD. Patients and Methods: Eighty-eight serum samples were obtained from 34 patients undergoing HCT either pretransplant (n = 28 samples) or at various time points posttransplant (n = 60 samples), including 22 samples obtained on the day of onset of acute GVHD symptoms. Serum proteomic spectra generated from a “training set” of known samples were used to identify distinct proteomic patterns that best categorized a sample as either pretransplant, posttransplant non-GVHD, or GVHD; these distinct proteomic signatures were subsequently used to classify samples from a masked “test” sample set into the appropriate diagnostic category. Results: Proteomic pattern analysis accurately distinguished GVHD samples from both posttransplant non-GVHD samples and pretransplant samples (100% specificity and 100% sensitivity in both cases). Furthermore, distinct serum proteomic signatures were identified that distinguished pretransplant from posttransplant non-GVHD samples (100% specificity and 94% sensitivity). Conclusion: These preliminary data suggest a potential application of SELDI-TOF-based proteomic analysis as a rapid and accurate method to diagnose acute GVHD. [Copyright &y& Elsevier]
AB - Copyright of Experimental Hematology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAFT versus host disease
KW - CELL transplantation
KW - BLOOD proteins
KW - MASS spectrometry
N1 - Accession Number: 20982593; Srinivasan, Ramaprasad 1,2 Daniels, Jasmine 1 Fusaro, Vincent 3 Lundqvist, Andreas 1 Killian, Jonathan K. 4 Geho, David 4 Quezado, Martha 4 Kleiner, David 4 Rucker, Sally 3 Espina, Virginia 4 Whiteley, Gordon 4 Liotta, Lance 4 Petricoin, Emmanuel 5 Pittaluga, Stefania 4 Hitt, Ben 6 Barrett, A.J. 1 Rosenblatt, Kevin 4 Childs, Richard W. 1; Email Address: childsr@nih.gov; Affiliation: 1: Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 2: Urologic Oncology Branch, Bethesda, MD 3: SAIC-Frederick, Inc., Bethesda, MD 4: Laboratory of Pathology, National Cancer Institute, Bethesda, Md., USA 5: Food and Drug Administration, Bethesda, Md., USA 6: Correlogic Systems, Inc., Bethesda, Md., USA; Source Info: Jun2006, Vol. 34 Issue 6, p796; Subject Term: GRAFT versus host disease; Subject Term: CELL transplantation; Subject Term: BLOOD proteins; Subject Term: MASS spectrometry; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.exphem.2006.02.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collins, Thomas F.X.
AU - Sprando, Robert L.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Eppley, Robert M.
AU - Hines, Fred A.
AU - Rorie, James
AU - Ruggles, Dennis I.
T1 - Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/06//
VL - 44
IS - 6
M3 - Article
SP - 747
EP - 757
SN - 02786915
AB - Abstract: Deoxynivalenol (DON, vomitoxin), is one of the most common contaminants of cereal grains world-wide. The effects of DON on fetal development were assessed in Charles River Sprague–Dawley rats. Pregnant female rats were gavaged once daily with DON at doses of 0, 0.5, 1, 2.5, or 5mg/kg body weight on gestation days (GD) 6–19. At cesarean section on GD 20, reproductive and developmental parameters were measured. All females survived to cesarean section. DON caused a dose-related increase in excessive salivation by the pregnant females, a reaction probably linked to the lack of emetic reflex in rats. At 5mg/kg, feed consumption and mean body weight gain were significantly decreased throughout gestation, mean weight gain (carcass weight), and gravid uterine weight were significantly reduced, 52% of litters (12/23) were totally resorbed, the average number of early and late deaths per litter was significantly increased, average fetal body weight and crown-rump length were significantly decreased, the incidence of runts was significantly increased, and the ossification of fetal sternebrae, centra, dorsal arches, vertebrae, metatarsals, and metacarpals was significantly decreased. At 2.5mg/kg, DON significantly decreased average fetal body weight, crown-rump length, and vertebral ossification. These effects may be secondary to maternal toxicity and the reduced size of the fetuses. The incidence of misaligned and fused sternebrae was significantly increased at 5.0mg/kg. No adverse developmental effects were observed at 0.5 and 1.0mg/kg. Dose-related increases in maternal liver weight-to-body weight ratios were observed in all treated groups (significant at 1, 2.5, and 5mg/kg). The weight changes were correlated with dose-related cytoplasmic alterations of hepatocytes. The NOEL for maternal toxicity for this study is 0.5mg/kg based on the dose-related increase in liver-body weight ratio at 1mg/kg. The NOEL for fetal toxicity is 1mg/kg based on the general reduction in fetal development at 2.5 and 5mg/kg. DON is considered a teratogen at 5mg/kg day in Sprague–Dawley rats based on the anomalous development of the sternebrae. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAIN
KW - CESAREAN section
KW - FETAL development
KW - ANTHROPOMETRY
KW - MAMMALS -- Body composition
KW - PREGNANCY
KW - Analysis of covariance ( ANCOVA )
KW - Analysis of variance ( ANOVA )
KW - Deoxynivalenol
KW - Deoxynivalenol ( DON )
KW - Developmental toxicity
KW - Gestation day ( GD )
KW - Intraperitoneal ( ip )
KW - Least significant difference ( LSD )
KW - Rat
KW - Trichothecene mycotoxin
KW - Vomitoxin
N1 - Accession Number: 20402692; Collins, Thomas F.X.; Email Address: tcollins@cfsan.fda.gov Sprando, Robert L. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Eppley, Robert M. 1 Hines, Fred A. 1 Rorie, James 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jun2006, Vol. 44 Issue 6, p747; Subject Term: GRAIN; Subject Term: CESAREAN section; Subject Term: FETAL development; Subject Term: ANTHROPOMETRY; Subject Term: MAMMALS -- Body composition; Subject Term: PREGNANCY; Author-Supplied Keyword: Analysis of covariance ( ANCOVA ); Author-Supplied Keyword: Analysis of variance ( ANOVA ); Author-Supplied Keyword: Deoxynivalenol; Author-Supplied Keyword: Deoxynivalenol ( DON ); Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: Gestation day ( GD ); Author-Supplied Keyword: Intraperitoneal ( ip ); Author-Supplied Keyword: Least significant difference ( LSD ); Author-Supplied Keyword: Rat; Author-Supplied Keyword: Trichothecene mycotoxin; Author-Supplied Keyword: Vomitoxin; NAICS/Industry Codes: 111190 Other grain farming; NAICS/Industry Codes: 111191 Oilseed and Grain Combination Farming; NAICS/Industry Codes: 484232 Dry bulk materials trucking, long distance; NAICS/Industry Codes: 484222 Dry bulk materials trucking, local; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; NAICS/Industry Codes: 312120 Breweries; NAICS/Industry Codes: 311214 Rice milling and malt manufacturing; NAICS/Industry Codes: 311211 Flour Milling; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.fct.2005.10.007
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ER -
TY - JOUR
AU - Mai, Hao T.
AU - Brodie, Darlene L.
AU - Meyers, Martin B.
AU - Baldo, Amelia L.
AU - Krantz, Zoe
AU - Weisz, Adrian
T1 - Determination of 2,4,6-triiodoresorcinol and other side reaction products and intermediates in the colour additive FD&C Red No. 3 (erythrosine) using high-performance liquid chromatography*.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2006/06//
VL - 23
IS - 6
M3 - Article
SP - 547
EP - 551
PB - Taylor & Francis Ltd
SN - 0265203X
AB - An HPLC method was developed for the quantitative determination of 2,4,6-triiodoresorcinol (I3R), 2-(2′,4′-dihydroxy-3′,5′-diiodobenzoyl)benzoic acid, resorcinol, phthalic acid, and sodium iodide in the colour additive FD&C Red No. 3 (erythrosine) (R3). Due to the fast decomposition of I3R in aqueous solutions, the dye portions analysed were dissolved in methanol and the determinations were performed in the freshly-made solutions. The HPLC method is rapid (50 min total analysis cycle, ∼⃒16 min to detect I3R and the other intermediates), simple to implement, and generates only small amounts of solvent waste. It was found to be applicable for use in routine batch-certification as shown by the analysis of test portions from 24 lots of R3 submitted for US-certification by domestic and foreign manufacturers during the past three years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Butylbenzylphthalate
KW - Methanol
KW - Food additives
KW - Benzoic acid
KW - Carboxylic acids
KW - Resorcinol
KW - Phthalic acid
KW - Sodium iodide
KW - High performance liquid chromatography
KW - 2
KW - 2,4,6-triiodoresorcinol
KW - 2-(2′,4′-dihydroxy-3′,5′-diiodobenzoyl)benzoic acid
KW - 2-(2′
KW - 4
KW - 4′-dihydroxy-3′
KW - 5′-diiodobenzoyl)benzoic acid
KW - 6-triiodoresorcinol
KW - erythrosine
KW - FD&C Red No. 3
KW - FD&C Red No. 3
KW - HPLC
KW - phthalic acid
KW - resorcinol
KW - sodium iodide
N1 - Accession Number: 20856533; Mai, Hao T. 1; Brodie, Darlene L. 1; Meyers, Martin B. 1; Baldo, Amelia L. 1; Krantz, Zoe 1; Weisz, Adrian 1; Email Address: aweisz@cfsan.fda.gov; Affiliations: 1: Office of Cosmetics and Colours, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: Jun2006, Vol. 23 Issue 6, p547; Thesaurus Term: Butylbenzylphthalate; Thesaurus Term: Methanol; Thesaurus Term: Food additives; Subject Term: Benzoic acid; Subject Term: Carboxylic acids; Subject Term: Resorcinol; Subject Term: Phthalic acid; Subject Term: Sodium iodide; Subject Term: High performance liquid chromatography; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2,4,6-triiodoresorcinol; Author-Supplied Keyword: 2-(2′,4′-dihydroxy-3′,5′-diiodobenzoyl)benzoic acid; Author-Supplied Keyword: 2-(2′; Author-Supplied Keyword: 4; Author-Supplied Keyword: 4′-dihydroxy-3′; Author-Supplied Keyword: 5′-diiodobenzoyl)benzoic acid; Author-Supplied Keyword: 6-triiodoresorcinol; Author-Supplied Keyword: erythrosine; Author-Supplied Keyword: FD&C Red No. 3; Author-Supplied Keyword: FD&C Red No. 3; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: phthalic acid; Author-Supplied Keyword: resorcinol; Author-Supplied Keyword: sodium iodide; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 5p; Illustrations: 2 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1080/02652030600550747
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Kim, Jang-Ho
AU - Lee, Ju-Woon
AU - Kim, Jae-Hun
AU - Seo, Ji-Hyun
AU - Han, Sang-Bae
AU - Chung, Hun-Jong
AU - Byun, Myung-Woo
T1 - Effect of gamma irradiation on Listeria ivanovii inoculated to iceberg lettuce stored at cold temperature
JO - Food Control
JF - Food Control
Y1 - 2006/06//
VL - 17
IS - 5
M3 - Article
SP - 397
EP - 401
SN - 09567135
AB - Abstract: A low-dose gamma irradiation considerably reduced the total plate counts, psychrotrophic bacteria, lactic acid bacteria, and inoculated Listeria ivanovii on shredded iceberg lettuce. The total plate count of the lettuce irradiated at 1.0kGy was reduced by 3.38log10 cfu/g on 0 storage day and to below the limit of detection (<2log10 cfu/g) as the cold storage was extended. Irradiation at 0.5kGy effectively reduced the psychrotrophic bacterial counts and lactic acid bacterial counts in the lettuce to below the limit of detection (2log10 cfu/g). Irradiation at 1.0kGy reduced L. ivanovii inoculated onto the shredded iceberg lettuce to below the limit of detection. The results showed that an irradiation at 1kGy eliminates the bacterial contamination from the lettuce sample without any sensorial quality defect. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAM-positive bacteria
KW - LACTIC acid
KW - PROKARYOTES
KW - FOOD -- Preservation
KW - Lactic acid bacteria
KW - Listeria ivanovii
KW - Low-dose irradiation
KW - Psychrotrophic counts
KW - Total plate counts
N1 - Accession Number: 18981129; Kim, Jang-Ho 1 Lee, Ju-Woon 1 Kim, Jae-Hun 1 Seo, Ji-Hyun 1 Han, Sang-Bae 2 Chung, Hun-Jong 3 Byun, Myung-Woo 1; Email Address: mwbyun@kaeri.re.kr; Affiliation: 1: Radiation Food Science and Biotechnology Team, Korea Atomic Energy Research Institute, Duckjindong 150, Yuseong, Daejeon 395-353, South Korea 2: Division of Food Standard, Korea Food and Drug Administration, Seoul 122-704, South Korea 3: Department of Pediatrics, Konkuk University Hospital, Chungju 380-704, South Korea; Source Info: Jun2006, Vol. 17 Issue 5, p397; Subject Term: GRAM-positive bacteria; Subject Term: LACTIC acid; Subject Term: PROKARYOTES; Subject Term: FOOD -- Preservation; Author-Supplied Keyword: Lactic acid bacteria; Author-Supplied Keyword: Listeria ivanovii; Author-Supplied Keyword: Low-dose irradiation; Author-Supplied Keyword: Psychrotrophic counts; Author-Supplied Keyword: Total plate counts; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodcont.2005.01.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nayak, Rajesh
AU - Stewart, Tabitha
AU - Nawaz, Mohamed
AU - Cerniglia, Carl
T1 - In vitro antimicrobial susceptibility, genetic diversity and prevalence of UDP-glucose 4-epimerase (galE) gene in Campylobacter coli and Campylobacter jejuni from Turkey production facilities
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/06//
VL - 23
IS - 4
M3 - Article
SP - 379
EP - 392
SN - 07400020
AB - Abstract: This study evaluated the genetic diversity of multi-drug resistant Campylobacter jejuni () and C. coli () isolated from 18 turkey houses. Antimicrobial resistances to ampicillin, ciprofloxacin and nalidixic acid were higher () in C. coli than in C. jejuni strains. PCR analysis indicated that 82% of total isolates tested, including 91% of C. jejuni and 70% of C. coli tested positive for a 496-bp UDP-glucose 4-epimerase (galE) gene. The diversity of isolates was mapped by antibiogram, SmaI-PFGE and flaA-RFLP typing methods using the discriminatory index (DI). RFLP was more suitable in discriminating C. coli (DI=0.895) than PFGE (DI=0.816) or antibiogram profile (DI=0.552), while either PFGE (DI=0.941) or RFLP (DI=0.942) could be used in discriminating C. jejuni strains. The combined PFGE and antibiogram dendrogram had the highest DI for both C. coli (0.910) and C. jejuni (0.968), suggesting that a combination of typing methods is more useful in examining the diverse Campylobacter population on turkey farms. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EFFECT of antibiotics on microorganisms
KW - BIODIVERSITY
KW - CAMPYLOBACTER
KW - TURKEY
KW - Antimicrobial resistance
KW - Campylobacter
KW - Genotyping
KW - PCR
KW - Turkey
N1 - Accession Number: 19860392; Nayak, Rajesh; Email Address: rnayak@nctr.fda.gov Stewart, Tabitha Nawaz, Mohamed 1 Cerniglia, Carl 1; Affiliation: 1: US Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jun2006, Vol. 23 Issue 4, p379; Subject Term: EFFECT of antibiotics on microorganisms; Subject Term: BIODIVERSITY; Subject Term: CAMPYLOBACTER; Subject Term: TURKEY; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Campylobacter; Author-Supplied Keyword: Genotyping; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Turkey; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.fm.2005.04.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Jeri L.
AU - Daniels, Robert D.
T1 - BONE MARROW DOSE ESTIMATES FROM WORK-RELATED MEDICAL X-RAY EXAMINATIONS GIVEN BETWEEN 1943 AND 1966 FOR PERSONNEL FROM FIVE U.S. NUCLEAR FACILITIES.
JO - Health Physics
JF - Health Physics
Y1 - 2006/06//
VL - 90
IS - 6
M3 - Article
SP - 544
EP - 553
SN - 00179078
AB - The article focuses on the study of bone marrow approximates dose from work-related medical x-ray examinations for personnel in U.S. nuclear facilities. The comprehension of dose from work-related medical x-ray examinations with occupational external dose in an epidemiological study may decrease the sorting of exposures and render precise assessment of leukemia risk from occupational exposure to ionizing radiation. Annual bone marrow doses due to work-related x-ray examinations were figured for cases and controls employed at nuclear facilities in a multi-site leukemia case-control study. The results showed that bone marrow dose from work-related photoflurographic and lumbar spine x-ray examinations may be important compared to occupational bone marrow dose.
KW - Radiation
KW - Nuclear facilities
KW - Ionizing radiation
KW - Nuclear energy
KW - X-rays
KW - Bone marrow
KW - Medical screening
KW - Nuclear power plants -- Employees
KW - United States
KW - dose assessment
KW - exposure;occupational
KW - radiation;medical
KW - x rays
N1 - Accession Number: 21010120; Anderson, Jeri L.; Daniels, Robert D. 1; Email Address: JLAnderson@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations and Field Studies (DSHEFS), 4676 Columbia Pkwy, Mail Stop R-44, Cincinnati, OH 45226; Issue Info: Jun2006, Vol. 90 Issue 6, p544; Thesaurus Term: Radiation; Thesaurus Term: Nuclear facilities; Thesaurus Term: Ionizing radiation; Thesaurus Term: Nuclear energy; Subject Term: X-rays; Subject Term: Bone marrow; Subject Term: Medical screening; Subject Term: Nuclear power plants -- Employees; Subject: United States; Author-Supplied Keyword: dose assessment; Author-Supplied Keyword: exposure;occupational; Author-Supplied Keyword: radiation;medical; Author-Supplied Keyword: x rays; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 221113 Nuclear Electric Power Generation; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
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DB - eih
ER -
TY - JOUR
ID - 106346174
T1 - Clinical trials for a preventive HIV vaccine in adolescents.
AU - Sheets R
Y1 - 2006///2006 Summer
N1 - Accession Number: 106346174. Language: English. Entry Date: 20061013. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 101153266.
KW - Clinical Trials
KW - HIV Infections -- Prevention and Control -- In Adolescence
KW - Vaccines
KW - Adolescence
KW - Africa
KW - Female
KW - HIV Infections -- Epidemiology
KW - Male
SP - 7
EP - 10
JO - HIV Nursing
JF - HIV Nursing
JA - HIV NURS
VL - 6
IS - 2
CY - London,
PB - Mediscript Ltd.
SN - 1474-7359
AD - US Public Health Service, Vaccine Scientific and Regulatory Specialist, National Institute of Allergy and Infectious Diseases, Bethesda, USA
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DB - rzh
ER -
TY - JOUR
AU - Park, J-H.
AU - Cox-Ganser, J.
AU - Rao, C.
AU - Kreiss, K.
T1 - Fungal and endotoxin measurements in dust associated with respiratory symptoms in a water-damaged office building.
JO - Indoor Air
JF - Indoor Air
Y1 - 2006/06//
VL - 16
IS - 3
M3 - Article
SP - 192
EP - 203
PB - Wiley-Blackwell
SN - 09056947
AB - We investigated the associations of fungal and endotoxin levels in office dust with respiratory health in 888 (67% participation) occupants of a water-damaged building. We analyzed floor and chair dusts from 338 workstations for culturable fungi and endotoxin. Based on averages, we ranked each floor of the building as low, medium, or high for occupants’ exposure to each of these agents. Multivariate logistic regression models for building-related symptoms included this ranking of fungi and endotoxin, age, gender, race, smoking status, and duration of occupancy. Using floor dust measures, we found significantly increased odds for lower respiratory symptoms [wheeze, chest tightness, attacks of shortness of breath, and attacks of cough: odds ratios (OR) = 1.7 (95% confidence interval (CI): 1.02–2.77) to 2.4 (95% CI: 1.29–4.59)], throat irritation [OR = 1.7, (95% CI: 1.06–2.82)], and rash/itchy skin [OR = 3.0, (95% CI: 1.47–6.19)] in the highest fungal exposure group compared to the lowest, with generally linear exposure–response relationships. Nonlinear relationships were observed for many of these symptoms and endotoxin in floor dust. Interaction models showed that endotoxin modified effects of fungi on respiratory symptoms. Our findings of exposure interactions and exposure–response relationships of fungal and endotoxin with increased risk of building-related symptoms contribute to an understanding of the role of microbial agents in building-related asthma and respiratory and systemic symptoms. Practical Implications Our demonstration of exposure–response relationships between measurements of fungi and/or endotoxin in floor dusts and building-related symptoms implies that microbial agents in floor dust may be a good surrogate measure for dampness-related bioaerosol exposure, considering that measurements of microbial agents in air often fail to demonstrate the associations between exposure and health. In addition, our finding that endotoxin exposure may change the effect of fungal exposure (and vice versa) on respiratory heath suggests that exposure to both fungi and endotoxin should be assessed in epidemiological investigations examining the effect of fungal or endotoxin exposure on respiratory health in indoor environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Endotoxins
KW - Fungi
KW - Office buildings
KW - Air pollution
KW - Bioaerosol
KW - Endotoxin
KW - Exposure–Response Relations
KW - Exposure--Response Relations
KW - Office Building
KW - Respiratory Symptoms
KW - Water Damage
N1 - Accession Number: 20620748; Park, J-H. 1; Email Address: gzp8@cdc.gov; Cox-Ganser, J. 1; Rao, C. 1; Kreiss, K. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, Morgantown WV, USA; Issue Info: Jun2006, Vol. 16 Issue 3, p192; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Endotoxins; Thesaurus Term: Fungi; Thesaurus Term: Office buildings; Thesaurus Term: Air pollution; Author-Supplied Keyword: Bioaerosol; Author-Supplied Keyword: Endotoxin; Author-Supplied Keyword: Exposure–Response Relations; Author-Supplied Keyword: Exposure--Response Relations; Author-Supplied Keyword: Office Building; Author-Supplied Keyword: Respiratory Symptoms; Author-Supplied Keyword: Water Damage; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 12p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2005.00415.x
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DB - eih
ER -
TY - JOUR
AU - Coben, J. H.
AU - Steiner, C. A.
AU - Barrett, M.
AU - Merrill, C. T.
AU - Adamson, D.
T1 - Completeness of cause of injury coding in healthcare administrative databases in the United States, 2001.
JO - Injury Prevention (1353-8047)
JF - Injury Prevention (1353-8047)
Y1 - 2006/06//
VL - 12
IS - 3
M3 - Article
SP - 199
EP - 201
SN - 13538047
AB - Objectives: To determine the completeness of external cause of injury coding (E-coding) within healthcare administrative databases in the United States and to identify factors that contribute to variations in E-code reporting across states. Design: Cross sectional analysis of the 2001 Healthcare Cost and Utilization Project (HCUP), including 33 State Inpatient Databases (SID), a Nationwide Inpatient Sample (NIS), and nine State Emergency Department Databases (SEDD). To assess state reporting practices, structured telephone interviews were conducted with the data organizations that participate in HCUP. Results: The percent of injury records with an injury E-code was 86% in HCUP's nationally representative database, the NIS. For the 33 states represented in the SID, completeness averaged 87%, with more than half of the states reporting E-codes on at least 90% of injuries. In the nine states also represented in the SEDD, completeness averaged 93%. Twenty two states had mandates for E-code reporting, but only eight had provisions for enforcing the mandates. These eight states had the highest rates of E-code completeness. Conclusions: E-code reporting in administrative databases is relatively complete, but there is significant variation in completeness across the states. States with mandates for the collection of E-codes and with a mechanism to enforce those mandates had the highest rates of E-code reporting. Nine statewide ED data systems demonstrate consistently high E-coding completeness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Injury Prevention (1353-8047) is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH services administration
KW - HOSPITAL records
KW - MEDICAL records
KW - HOSPITALS -- Admission & discharge
KW - SOCIAL surveys
KW - HOSPITALS -- Research
KW - UNITED States
N1 - Accession Number: 21609431; Coben, J. H. 1; Email Address: jcoben@hsc.wvu.edu Steiner, C. A. 2 Barrett, M. 3 Merrill, C. T. 4 Adamson, D. 4; Affiliation: 1: Control Research Center, West Virginia University, Morgantown, WV, USA 2: Agency for Healthcare Research and Quality, Center for Delivery, Organization, and Markets, Rockville, MD, USA 3: Barrett, Inc, San Diego, CA, USA 4: Medstat, Washington, DC, USA; Source Info: Jun2006, Vol. 12 Issue 3, p199; Subject Term: HEALTH services administration; Subject Term: HOSPITAL records; Subject Term: MEDICAL records; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: SOCIAL surveys; Subject Term: HOSPITALS -- Research; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1136/ip.2005.010512
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106332115
T1 - NPDB-HIPDB 101: an introduction to the National Practitioner Data Bank and the Healthcare Integrity and Protection Data Bank.
AU - Illich D
Y1 - 2006/06//
N1 - Accession Number: 106332115. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Blind Peer Reviewed; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101264817.
KW - Clinical Nurse Specialists
KW - National Practitioner Data Bank
KW - Nurse Practitioners
KW - Professional Discipline
KW - Drug Enforcement Administration
KW - Health Insurance Portability and Accountability Act
KW - Information Resources
KW - Legislation
KW - Malpractice
KW - Medicaid
KW - Medicare
KW - Nurse Anesthetists
KW - Nurse Midwives
KW - Quality of Health Care -- Legislation and Jurisprudence
KW - United States
SP - 397
EP - 403
JO - Journal for Nurse Practitioners
JF - Journal for Nurse Practitioners
JA - J NURSE PRACT
VL - 2
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Numerous references are made in professional literature to national practitioner data banks, but not a lot of specific information is available about what they include about nurse practitioners and how they are accessed. This article provides an authoritative report about the two federal medical disciplinary action data banks and what nurse practitioners should know about them.
SN - 1555-4155
AD - Writer-Editor, US Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions, Practitioner Data Banks Branch; dillich@hrsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hard, David L.
AU - Myers, John R.
T1 - Fatal Work-Related Injuries in the Agriculture Production Sector Among Youth in the United States, 1992-2002.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2006/06//
VL - 11
IS - 2
M3 - Article
SP - 57
EP - 65
SN - 1059924X
AB - Youth working on farms face unique risks that arc not present for many other young workers, including machinery, large animals, electrical hazards, chemical hazards and excessive noise. This research identified the number and rate of occupational fatalities for youth working in the agriculture production industry, which is most closely affiliated with farming, for the years 1992-2002. The Census of Fatal Occupational Injuries (CFOI), developed by the Bureau of Labor Statistics (BLS), was the database used for the analysis. There were 310 work-related deaths to youth less than 20 years of age from 1992 through 2002 in the agriculture production sector. This compares to 1,958 total fatalities for all workers less than 20 years of age for the same lime period. The number of agricultural production fatalities to youth has shown a general downward trend over this time period. The rates were higher for young workers in agriculture production than for young workers in all industries by a factor of 3.6. Fifteen year olds had the highest fatality rates with the crop production sector having a rate six times that of all 15 year old workers. The objective of this descriptive research was to identify, prioritize and publicize the risks to children and youth who work on farms in order to provide public health and safely professionals relevant information upon which to base decisions for interventions or other prevention activities for this priority population. This research also has direct applications for farm parents and safety and health professionals who work with the priority population of young agricultural workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURE
KW - WORK-related injuries
KW - TEENAGERS
KW - CHILD mortality
KW - FARMS
KW - YOUNG workers
KW - MACHINERY
KW - ANIMALS
KW - HAZARDS
KW - NOISE
KW - AGRICULTURAL laborers
KW - adolescent
KW - Agriculture
KW - child mortality
KW - occupational accidents
N1 - Accession Number: 23410201; Hard, David L. 1; Email Address: DHard@cdc.gov Myers, John R. 2; Affiliation: 1: Health Scientist with the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch 2: Statistician with the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch; Source Info: 2006, Vol. 11 Issue 2, p57; Subject Term: AGRICULTURE; Subject Term: WORK-related injuries; Subject Term: TEENAGERS; Subject Term: CHILD mortality; Subject Term: FARMS; Subject Term: YOUNG workers; Subject Term: MACHINERY; Subject Term: ANIMALS; Subject Term: HAZARDS; Subject Term: NOISE; Subject Term: AGRICULTURAL laborers; Author-Supplied Keyword: adolescent; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: child mortality; Author-Supplied Keyword: occupational accidents; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 417990 All other machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333999 All Other Miscellaneous General Purpose Machinery Manufacturing; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; Number of Pages: 9p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1300/J096v11n02̱09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23410201&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106200224
T1 - Fatal work-related injuries in the agriculture production sector among youth in the United States, 1992-2002.
AU - Hard DL
AU - Myers JR
Y1 - 2006/06//
N1 - Accession Number: 106200224. Language: English. Entry Date: 20071130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Accidents, Occupational
KW - Agriculture
KW - Accidents, Occupational -- Trends
KW - Adolescence
KW - Adult
KW - Cause of Death
KW - Child
KW - Demography
KW - Female
KW - Male
KW - Mortality
KW - Risk Factors
KW - Safety
KW - United States
KW - Human
SP - 57
EP - 65
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 11
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Youth working on farms face unique risks that are not present for many other young workers, including machinery, large animals, electrical hazards, chemical hazards and excessive noise. This research identified the number and rate of occupational fatalities for youth working in the agriculture production industry, which is most closely affiliated with farming, for the years 1992-2002. The Census of Fatal Occupational Injuries (CFOI), developed by the Bureau of Labor Statistics (BLS), was the database used for the analysis. There were 310 work-related deaths to youth less than 20 years of age from 1992 through 2002 in the agriculture production sector. This compares to 1,958 total fatalities for all workers less than 20 years of age for the same time period. The number of agricultural production fatalities to youth has shown a general downward trend over this time period. The rates were higher for young workers in agriculture production than for young workers in all industries by a factor of 3.6. Fifteen year olds had the highest fatality rates with the crop production sector having a rate six times that of all 15 year old workers. The objective of this descriptive research was to identify, prioritize and publicize the risks to children and youth who work on farms in order to provide public health and safety professionals relevant information upon which to base decisions for interventions or other prevention activities for this priority population. This research also has direct applications for farm parents and safety and health professionals who work with the priority population of young agricultural workers.
SN - 1059-924X
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, WV 26505, USA. DHard@cdc.gov
U2 - PMID: 17135143.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Reuter, Gábor
AU - Fodor, Domonka
AU - Kátai, Andrea
AU - Szűcs, György
T1 - Identification of a novel variant of human hepatitis E virus in Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006/06//
VL - 36
IS - 2
M3 - Article
SP - 100
EP - 102
SN - 13866532
AB - Abstract: First human case of hepatitis E infection detected in Hungary is reported. This hepatitis E virus (HEV), Hungary1, belongs to genotype 3 and had 95% and 90% nucleotide identity within the capsid region of the European swine and human (Greece2) strains, respectively. Hungary1 represents a potential novel human variant of HEV in genus Hepevirus. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS E
KW - VIRAL hepatitis
KW - VIRUS diseases
KW - NUCLEOTIDES
KW - HUNGARY
KW - enzyme-linked immunoassay ( ELISA )
KW - Genotype 3 hepatitis E virus
KW - hepatitis A virus ( HAV )
KW - hepatitis B surface antigen ( HBsAg )
KW - hepatitis C virus ( HCV )
KW - hepatitis E virus ( HEV )
KW - Non-A
KW - Non-C hepatitis
KW - open reading frame ( ORF )
KW - reverse transcription-polymerase chain reaction ( RT-PCR )
KW - ribonucleic acid ( RNA )
N1 - Accession Number: 20823509; Reuter, Gábor 1; Email Address: reuterg@baranya.antsz.hu Fodor, Domonka 2 Kátai, Andrea 3 Szűcs, György 1; Affiliation: 1: Regional Laboratory of Virology, ÁNTSZ Baranya County Institute of State Public Health Service, Szabadság u. 7, Pécs, Hungary 2: Department of Infectology, City Hospital of Szeged, Csongrád County, Szeged, Hungary 3: Regional Laboratory of Microbiology, ÁNTSZ Csongrád County Institute of State Public Health Service, Szeged, Hungary; Source Info: Jun2006, Vol. 36 Issue 2, p100; Subject Term: HEPATITIS E; Subject Term: VIRAL hepatitis; Subject Term: VIRUS diseases; Subject Term: NUCLEOTIDES; Subject Term: HUNGARY; Author-Supplied Keyword: enzyme-linked immunoassay ( ELISA ); Author-Supplied Keyword: Genotype 3 hepatitis E virus; Author-Supplied Keyword: hepatitis A virus ( HAV ); Author-Supplied Keyword: hepatitis B surface antigen ( HBsAg ); Author-Supplied Keyword: hepatitis C virus ( HCV ); Author-Supplied Keyword: hepatitis E virus ( HEV ); Author-Supplied Keyword: Non-A; Author-Supplied Keyword: Non-C hepatitis; Author-Supplied Keyword: open reading frame ( ORF ); Author-Supplied Keyword: reverse transcription-polymerase chain reaction ( RT-PCR ); Author-Supplied Keyword: ribonucleic acid ( RNA ); Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jcv.2006.01.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20823509&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106251436
T1 - Accessing care for U.S./Mexico border populations living with HIV/AIDS: the role of HRSA's HIV/AIDS bureau and the Special Projects of National Significance.
AU - Eldred L
AU - Cheever L
AU - Parham-Hopson D
Y1 - 2006/06//
N1 - Accession Number: 106251436. Language: English. Entry Date: 20070316. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. NLM UID: 100968761.
KW - Government Agencies
KW - Health Services Accessibility
KW - HIV Infections -- Therapy
KW - Role
KW - Acquired Immunodeficiency Syndrome -- Diagnosis
KW - Community Health Services
KW - Counseling
KW - HIV Education
KW - Medically Underserved
KW - Mexico
KW - United States
SP - 7
EP - 13
JO - Journal of HIV/AIDS & Social Services
JF - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS SOC SERV
VL - 5
IS - 2
PB - Taylor & Francis Ltd
AB - The Health Resources Services Administration (HRSA) provides health-care to underserved areas in the U.S. and addresses disparities in health-care among U.S. populations. HRSA's Ryan White CARE Act provides HIV care and supportive services for persons with HIV and AIDS in the U.S. and its territories. Five projects were funded as Special Projects of National Significance (SPNS) from 2001-2005, to improve care and access to HIV services along the U.S.-Mexican Border. These projects developed culturally appropriate and innovative outreach strategies, expanded counseling and testing in border communities, assured continuity of care through intensive case management services and increased clinical capacity through provider training.
SN - 1538-1501
AD - Department of Health and Human Services, Health Resources Services Administration, HIV/AIDS Bureau, 5600 Fishers Lane, Rockville, MD 20857; LEldred@hrsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Epstein, Suzanne L.
T1 - Reply to Carrat and Lavenu.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/06//6/1/2006
VL - 193
IS - 11
M3 - Letter
SP - 1613
EP - 1614
SN - 00221899
AB - A letter to the editor is presented in response to the article titled "Heterosubtypic Immunity to Influenza:Right Hypothesis, Wrong Comparison," by F. Carrat and A. Lavenu, published in a 2006 issue of the "Journal of Infectious Diseases."
KW - LETTERS to the editor
KW - INFLUENZA
N1 - Accession Number: 20815146; Epstein, Suzanne L. 1; Email Address: suzanne.epstein@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: 6/1/2006, Vol. 193 Issue 11, p1613; Subject Term: LETTERS to the editor; Subject Term: INFLUENZA; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sergeev, Nikolay
AU - Distler, Margaret
AU - Vargas, Melany
AU - Chizhikov, Vladimir
AU - Herold, Keith E.
AU - Rasooly, Avraham
T1 - Microarray analysis of Bacillus cereus group virulence factors
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2006/06//
VL - 65
IS - 3
M3 - Article
SP - 488
EP - 502
SN - 01677012
AB - Abstract: Bacillus cereus, B. thuringiensis and B. anthracis are closely related medically and economically important bacterial species that belong to the B. cereus group. Members of the B. cereus group carry genes encoding several important virulence factors, including enterotoxins, phospholipases and exotoxins. Since it is difficult to differentiate among B. cereus group members, and because Bacillus virulence factors are very important for pathogenesis, we explored the use of microarray-based detection of virulence factor genes as a tool for strain identification and for determining virulence. Our method requires an initial multiplex PCR amplification step, followed by identification of the PCR amplicons by hybridization to an oligonucleotide microarray containing genes for all three types of Bacillus virulence factors including B. anthracis virulence factors. The DNA chip described here contains 21 identical arrays used for analysis of seven samples in triplicates. Using the arrays, we found that virulence factors are present in several combinations in the strains analyzed. This work also demonstrates the potential of oligonucleotide microarrays for medical, food safety and biodefense analysis of microbial pathogens. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS cereus
KW - GENES
KW - VIRULENCE (Microbiology)
KW - MICROBIOLOGY
KW - Microarray
KW - Microbial detection
KW - Microbial pathogen
N1 - Accession Number: 20820562; Sergeev, Nikolay 1 Distler, Margaret 2 Vargas, Melany 2 Chizhikov, Vladimir 3 Herold, Keith E. 2 Rasooly, Avraham 1,4; Email Address: rasoolya@mail.nih.gov; Affiliation: 1: FDA Center for Devices and Radiological Health, United States 2: University of Maryland, United States 3: FDA Center for Biologics Evaluation and Research, United States 4: NIH-National Cancer Institute, United States; Source Info: Jun2006, Vol. 65 Issue 3, p488; Subject Term: BACILLUS cereus; Subject Term: GENES; Subject Term: VIRULENCE (Microbiology); Subject Term: MICROBIOLOGY; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Microbial detection; Author-Supplied Keyword: Microbial pathogen; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.mimet.2005.09.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiang, H. Joanna
AU - Stocks, Carol
AU - Wong, Cindy J.
T1 - Disparities Between Two Common Data Sources on Hospital Nurse Staffing.
JO - Journal of Nursing Scholarship
JF - Journal of Nursing Scholarship
Y1 - 2006///2006 2nd Quarter
VL - 38
IS - 2
M3 - Article
SP - 187
EP - 193
PB - Wiley-Blackwell
SN - 15276546
AB - Purpose: To compare nurse staffing measures derived from two widely used data sources: the American Hospital Association (AHA) Annual Survey of Hospitals and the California Office for Statewide Health Planning and Development (OSHPD). Design: Descriptive cross-sectional study with measures of nurse staffing level and skill mix constructed from each database for 372 nonfederal, acute care hospitals in California. Methods: Discrepancies in nurse staffing estimates between the two databases were examined. Relationships of nurse staffing with risk-adjusted patient outcomes (decubitus ulcer, failure to rescue, and mortality) were assessed through multivariate analyses and compared for nursing measures derived from the two databases. Findings: For small, rural, or nonteaching hospitals, AHA reported substantially higher registered nurse (RN) hours per patient day than did OSHPD. RN proportion among licensed nurses matched most closely in the two databases. RN hours per patient day derived from both databases showed significant inverse relationships with decubitus ulcer and mortality, and the association was stronger for the measure based on the OSHPD data. RN proportion derived from the OSHPD data was significantly associated with all three patient outcomes, but the AHA measure had a significant relationship only with decubitus ulcer. Conclusions: Compared with the AHA survey, the OSHPD data on hospital nurse staffing appear to be more complete and also were more closely associated with patient outcomes. Efforts to refine the AHA survey as a national database for nurse staffing will significantly enhance the capacity for monitoring nurse workforce and its effect on quality of care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nursing Scholarship is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSES
KW - MEDICAL personnel
KW - OUTCOME assessment (Medical care)
KW - DATABASES
KW - MEDICAL care -- Evaluation
KW - ELECTRONIC information resources
KW - data collection
KW - nurse staffing
KW - patient outcomes
N1 - Accession Number: 20753708; Jiang, H. Joanna 1; Email Address: joanna.jiang@ahrq.gov Stocks, Carol 2 Wong, Cindy J. 3; Affiliation: 1: Social Scientist, Agency for Healthcare Research and Quality, Rockville, MD 2: Assistant Data Coordinator, Agency for Healthcare Research and Quality, Rockville, MD 3: Brandeis University, Boston, MA; Source Info: 2006 2nd Quarter, Vol. 38 Issue 2, p187; Subject Term: NURSES; Subject Term: MEDICAL personnel; Subject Term: OUTCOME assessment (Medical care); Subject Term: DATABASES; Subject Term: MEDICAL care -- Evaluation; Subject Term: ELECTRONIC information resources; Author-Supplied Keyword: data collection; Author-Supplied Keyword: nurse staffing; Author-Supplied Keyword: patient outcomes; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1547-5069.2006.00099.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20753708&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106341339
T1 - Disparities between two common data sources on hospital nurse staffing.
AU - Jiang HJ
AU - Stocks C
AU - Wong CJ
Y1 - 2006///2006 2nd Quarter
N1 - Accession Number: 106341339. Language: English. Entry Date: 20060929. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2006 2nd Quarter. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 100911591.
KW - Nursing Staff, Hospital
KW - Personnel Staffing and Scheduling
KW - California
KW - Comparative Studies
KW - Cross Sectional Studies
KW - Databases
KW - Descriptive Research
KW - Descriptive Statistics
KW - Empirical Research
KW - Geographic Factors
KW - Government Agencies -- California
KW - Hospitals -- Classification
KW - Hospitals -- Organizations
KW - Multivariate Analysis
KW - Nursing Assistants
KW - Outcomes (Health Care)
KW - Practical Nurses
KW - Regression
KW - RN Mix
KW - Human
SP - 187
EP - 193
JO - Journal of Nursing Scholarship
JF - Journal of Nursing Scholarship
JA - J NURS SCHOLARSH
VL - 38
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - PURPOSE: To compare nurse staffing measures derived from two widely used data sources: the American Hospital Association (AHA) Annual Survey of Hospitals and the California Office for Statewide Health Planning and Development (OSHPD). DESIGN: Descriptive cross-sectional study with measures of nurse staffing level and skill mix constructed from each database for 372 nonfederal, acute care hospitals in California. METHODS: Discrepancies in nurse staffing estimates between the two databases were examined. Relationships of nurse staffing with risk-adjusted patient outcomes (decubitus ulcer, failure to rescue, and mortality) were assessed through multivariate analyses and compared for nursing measures derived from the two databases. FINDINGS: For small, rural, or nonteaching hospitals, AHA reported substantially higher registered nurse (RN) hours per patient day than did OSHPD. RN proportion among licensed nurses matched most closely in the two databases. RN hours per patient day derived from both databases showed significant inverse relationships with decubitus ulcer and mortality, and the association was stronger for the measure based on the OSHPD data. RN proportion derived from the OSHPD data was significantly associated with all three patient outcomes, but the AHA measure had a significant relationship only with decubitus ulcer. CONCLUSIONS: Compared with the AHA survey, the OSHPD data on hospital nurse staffing appear to be more complete and also were more closely associated with patient outcomes. Efforts to refine the AHA survey as a national database for nurse staffing will significantly enhance the capacity for monitoring nurse workforce and its effect on quality of care.
SN - 1527-6546
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. joanna.jiang@ahrq.gov
U2 - PMID: 16773924.
DO - 10.1111/j.1547-5069.2006.00099.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106341339&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Harris, Gabriel K.
AU - Yong Qian
AU - Leonard, Stephen S.
AU - Sbarra, Deborah C.
AU - Xianglin Shi
T1 - Luteolin and Chrysin Differentially Inhibit Cyclooxygenase-2 Expression and Scavenge Reactive Oxygen Species but Similarly Inhibit Prostaglandin-E2 Formation in RAW 264.7 Cells.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/06//
VL - 136
IS - 6
M3 - Article
SP - 1517
EP - 1521
SN - 00223166
AB - Inflammation and oxidative stress are associated with cancer, atherosclerosis, and other chronic diseases. Dietary flavonoids have been reported to possess antiinflammatory and antioxidant properties, but their mechanisms of action and structure-activity relations have not been fully investigated. We hypothesized that differences in antioxidant activity between the structurally similar flavones, luteolin and chrysin (differing only in B-ring hydroxylation patterns), would differentially affect inflammation-associated Cox-2 expression and PGE2 formation. Pretreatment of RAW 264.7 macrophage-like cells with 25, 50, or 100 μmol/L concentrations of luteolin inhibited lipopolysaccharide (LPS)-induced Cox-2 protein expression (P < 0.0001). Chrysin pretreatment did not reduce LPS-induced Cox-2 protein expression at any level tested. Conversely, both luteolin and chrysin completely suppressed LPS-induced PGE2 formation (P < 0.001). Luteolin, but not chrysin, inhibited xanthine/xanthine oxidase-generated superoxide formation at 100 μmol/L in a cell-free system (P < 0.001). Although both luteolin and chrysin reduced LPS-induced hydroxyl radical formation relative to the positive control (P < 0.001), luteolin was superior to chrysin (P = 0.003). In summary, luteolin and chrysin suppressed PGE2 formation equally well, despite differential effects on Cox-2 protein expression and on superoxide and hydroxyl radical scavenging. These data indicate that flavones may display similar antiinflammatory activity via different mechanisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLAMMATION
KW - OXIDATIVE stress
KW - CHRONIC diseases
KW - NUTRITION
KW - FLAVONOIDS
KW - ANTI-inflammatory agents
KW - CYCLOOXYGENASE 2
KW - PROSTAGLANDINS
KW - ACTIVE oxygen
KW - UNITED States
KW - chrysin
KW - cyclooxygenase-2
KW - luteolin
KW - prostaglandin E2
KW - reactive oxygen species
N1 - Accession Number: 20994752; Harris, Gabriel K. 1; Email Address: harrisk@ba.ars.usda.gov Yong Qian 2 Leonard, Stephen S. 2 Sbarra, Deborah C. 2 Xianglin Shi 2; Affiliation: 1: United States Department of Agriculture, Diet and Human Performance Laboratory, Beltsville, MD 20705 2: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, WV 26505; Source Info: Jun2006, Vol. 136 Issue 6, p1517; Subject Term: INFLAMMATION; Subject Term: OXIDATIVE stress; Subject Term: CHRONIC diseases; Subject Term: NUTRITION; Subject Term: FLAVONOIDS; Subject Term: ANTI-inflammatory agents; Subject Term: CYCLOOXYGENASE 2; Subject Term: PROSTAGLANDINS; Subject Term: ACTIVE oxygen; Subject Term: UNITED States; Author-Supplied Keyword: chrysin; Author-Supplied Keyword: cyclooxygenase-2; Author-Supplied Keyword: luteolin; Author-Supplied Keyword: prostaglandin E2; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 5p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ghoshal, Kalpana
AU - Xin Li
AU - Datta, Jharna
AU - Shoumei Bai
AU - Pogribny, Igor
AU - Pogribny, Marta
AU - Yan Huang
AU - Young, Donn
AU - Jacob, Samson T.
AU - Li, Xin
AU - Bai, Shoumei
AU - Huang, Yan
T1 - A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/06//
VL - 136
IS - 6
M3 - journal article
SP - 1522
EP - 1527
SN - 00223166
AB - Aberrations in methylation profile of the genome occur in human cancers induced by folate deficiency. To elucidate the underlying mechanism, male F344 rats were fed a diet deficient in l-methionine and devoid of folic acid and choline (FMD diet), which is known to induce hepatocellular carcinomas. We investigated changes in the DNA methylation machinery, namely, de novo DNA methyltransferases (Dnmt3a and 3b), maintenance DNA methyltransferase (Dnmt1), and methyl CpG binding proteins (MBDs), in rat livers during early stages of tumorigenesis. RT-PCR and Western blot analyses revealed differential expression of these proteins in the livers of rats fed the FMD diet. Although the hepatic Dnmt1 mRNA level declined with age (P < 0.001), it was elevated (P < 0.001) in deficient rats compared with controls. The changes in hepatic Dnmt1 protein level with the diet correlated with its mRNA levels (r = 0.60, P = 0.002). Similarly, the Dnmt3a mRNA level was elevated in rats fed the FMD diet (P < 0.001), whereas the Dnmt3b level (mRNA and protein) was not affected by diet or age. Compared with controls, hepatic MBD1-3 RNA levels increased (P < 0.001) and the protein levels of MBD1, 2, and 4 were elevated (P < 0.001) in the deficient rats. In both diet groups, hepatic MBD2 protein decreased (P < 0.001), whereas MeCP2 protein increased (P < 0.001) with age. These results demonstrate that a combined folate and methyl deficiency alters components of the DNA methylation machinery by both transcriptional and posttranscriptional mechanisms during early stages of hepatocarcinogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMOSOME abnormalities
KW - METHYLATION
KW - GENOMES
KW - CANCER
KW - LIVER -- Cancer
KW - METHYLTRANSFERASES
KW - FOLIC acid
KW - CARRIER proteins
KW - UNITED States
KW - Dnmtl/3a/3b
KW - folate- and methyl-deficient diet
KW - hepatocarcinogenesis
KW - MBD1-4
N1 - Accession Number: 20994753; Ghoshal, Kalpana 1; Email Address: ghoshal.1@osu.edu Xin Li 1 Datta, Jharna 1 Shoumei Bai 1 Pogribny, Igor 2 Pogribny, Marta 2 Yan Huang 1 Young, Donn 3 Jacob, Samson T. 1,3,4 Li, Xin Bai, Shoumei Huang, Yan; Affiliation: 1: Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210 2: Division of Biochemical Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079 3: Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 4: Department of Internal Medicine, Ohio State University, Columbus, OH 43210; Source Info: Jun2006, Vol. 136 Issue 6, p1522; Subject Term: CHROMOSOME abnormalities; Subject Term: METHYLATION; Subject Term: GENOMES; Subject Term: CANCER; Subject Term: LIVER -- Cancer; Subject Term: METHYLTRANSFERASES; Subject Term: FOLIC acid; Subject Term: CARRIER proteins; Subject Term: UNITED States; Author-Supplied Keyword: Dnmtl/3a/3b; Author-Supplied Keyword: folate- and methyl-deficient diet; Author-Supplied Keyword: hepatocarcinogenesis; Author-Supplied Keyword: MBD1-4; Number of Pages: 6p; Illustrations: 2 Diagrams, 4 Charts; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106329849
T1 - An evaluation of conditions that may affect the performance of houseboat exhaust stacks in prevention of carbon monoxide poisonings from generators.
AU - Hammond DR
AU - Earnest GS
AU - Hall RM
AU - Feng A
Y1 - 2006/06//
N1 - Accession Number: 106329849. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; CEU; pictorial; research; tables/charts. Note: For CE see Suppl pages D54-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Carbon Monoxide Poisoning -- Prevention and Control
KW - Ships
KW - Arizona
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Field Studies
KW - Kruskal-Wallis Test
KW - Nonparametric Statistics
KW - Human
SP - 308
EP - 316
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - National Institute for Occupational Safety and Health (NIOSH) researchers evaluated two exhaust stack designs for reducing carbon monoxide (CO) exposures from gasoline-powered generator exhaust on houseboats. Tests were conducted (a) after dark, (b) in high-temperature and high-humidity environments, (c) during temperature inversions, (d) under various generator loads, and (e) at different houseboat trim angles. Two different designs of houseboat exhaust stacks were evaluated and compared with the side-exhaust configuration, which is standard on many houseboats. The two designs were flagpole and vertical stack. Both exhaust stacks performed dramatically better than the standard water level, side-exhaust configuration. The highest mean CO concentrations on the upper and lower decks of the houseboat with the vertical exhaust stack were 27 ppm and 17 ppm. The highest mean CO concentrations on the upper and lower decks of the houseboat with the modified flagpole stack were 5 ppm and 2 ppm. These findings are much lower than the 67 ppm and 341 ppm for the highest mean CO concentrations found on the upper and lower decks of houseboats having the usual side-exhausted configuration. The NIOSH evaluation also indicated that high-temperature and high-humidity levels, temperature inversions, generator loading, and houseboat trim angles had little effect on the exhaust stack performance. It also demonstrated the importance of proper design and installation of exhaust stacks to ensure that all exhaust gases are released through the stack. Based on the results of this work, NIOSH investigators continue to recommend that houseboat manufacturers, rental companies, and owners retrofit their gasoline-powered generators with exhaust stacks to reduce the hazard of CO poisoning and death to individuals on or near the houseboat.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Public Health Service and Division of Applied Research and Technology, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS-R5, Cincinnati, OH 45226; ahz0@cdc.gov
U2 - PMID: 16627369.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106329849&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106329855
T1 - Pilot measurements of ELF contact currents in some electric utility occupations.
AU - Bowman J
AU - Niple J
AU - Kavet R
Y1 - 2006/06//
N1 - Accession Number: 106329855. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; CEU; pictorial; research; tables/charts; tracings. Note: For CE see Suppl pages D54-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Electricity -- Adverse Effects
KW - Occupational Exposure -- Evaluation
KW - Occupational Hazards -- Evaluation
KW - Bone Marrow -- Physiology
KW - California
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Field Studies
KW - Heart -- Physiology
KW - Pilot Studies
KW - Human
SP - 323
EP - 333
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Contact currents from touching objects with different voltages can produce electric fields within the body that produce neurological and other biological effects. To begin measuring these exposures among electric utility workers, a new contact current meter (CCM) was tested in a pilot study at Southern California Edison. The CCM was worn for 82 full-shift measurements by 76 volunteers from eight occupations who did not work directly with energized electrical equipment. The volunteers were exposed to an average of 285.8 contact current events above the meter's 1-microA threshold, but most of these were electrostatic spark discharges. Fourteen employees experienced an average of 135.1 contact currents events whose primary frequency was 60 Hz. Using a circuit model of the human body, the average contact currents going from arm to arm was 9.8 microA (maximum = 178.0 microA), and the average going down the torso was 25.5 microA (maximum = 662.0). The maximum exposures were experienced by a technical support employee working in a substation. All measurements in this pilot study were below the 3000 microA maximum permissible exposure for contact currents set by the Institute of Electrical and Electronic Engineers (IEEE). Combining these current measurements with the results of high-resolution dosimetry, the internal electric fields averaged an estimated 1.7 mV/m in the heart (maximum = 21.0 mV/m), and 1.9 mV/m in the hematopoietic bone marrow in the torso (maximum = 56.5 mV/m). These internal electric fields from contact currents are below the basic restriction of 943 mV/m in the IEEE exposure standards but are above 1 mV/m, a level where biological effects have been often reported in laboratory studies. Safety concerns limited the measurements to de-energized equipment, so we did not obtain data on work in energized high-voltage environments, the most likely sources of high contact currents. This pilot study identified other improvements to the contact current meter that would make it better able to measure exposures in future health studies.
SN - 1545-9624
AD - NIOSH Physical Hazards Team, Engineering and Physical Hazards Branch, National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226; jdb0@cdc.gov
U2 - PMID: 16718950.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hnizdo, Eva
AU - Sircar, Kanta
AU - Glindmeyer, Henry W.
AU - Petsonk, Edward L.
T1 - Longitudinal Limits of Normal Decline in Lung Function in an Individual.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/06//
VL - 48
IS - 6
M3 - Article
SP - 625
EP - 634
SN - 10762752
AB - The article discusses the study that proposes a method of calculating longitudinal limits of normal decline (LND) in forced expiratory volume in one second to identify individuals with an excessive decline in lung functions and to compare the method with other published LND method. A longitudinal data from 11 workplace-based spirometric monitoring programs was conducted to evaluate effectiveness of each LND method in identifying a true excessive decline in forced expiratory volume in 1 second. The findings indicated that the proposed LND method was more effective than other method for identifying excessive declines.
KW - RESEARCH
KW - LUNGS
KW - CHEST (Anatomy)
KW - CARDIOPULMONARY system
KW - RESPIRATORY organs
KW - ORGANS (Anatomy)
N1 - Accession Number: 21478746; Hnizdo, Eva 1; Email Address: ehnizdo@cdc.gov Sircar, Kanta 1 Glindmeyer, Henry W. 2 Petsonk, Edward L. 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 2: Section of Pulmonary, Critical Care, and Environmental Medicine, Department of Medicine, Tulane Medical School, New Orleans, Louisiana; Source Info: Jun2006, Vol. 48 Issue 6, p625; Subject Term: RESEARCH; Subject Term: LUNGS; Subject Term: CHEST (Anatomy); Subject Term: CARDIOPULMONARY system; Subject Term: RESPIRATORY organs; Subject Term: ORGANS (Anatomy); Number of Pages: 10p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1097/01.jom.0000214351.18905.48
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21478746&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106136816
T1 - Longitudinal limits of normal decline in lung function in an individual.
AU - Hnizdo E
AU - Sircar K
AU - Glindmeyer HW
AU - Petsonk EL
Y1 - 2006/06//
N1 - Accession Number: 106136816. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Forced Expiratory Volume -- Evaluation
KW - Adult
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Lung Diseases, Obstructive -- Physiopathology
KW - Middle Age
KW - P-Value
KW - Prospective Studies
KW - Repeated Measures
KW - Spirometry
KW - Human
SP - 625
EP - 634
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 48
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1076-2752
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; ehnizdo@cdc.gov
U2 - PMID: 16766927.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136816&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105888000
T1 - Agency for Healthcare Research and Quality's National Quality and Disparities Reports emphasize patient safety.
AU - Clancy CM
AU - McNeill D
AU - Moy E
AU - Dayton E
Y1 - 2006/06//
N1 - Accession Number: 105888000. Language: English. Entry Date: 20080418. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Legislation -- United States
KW - Patient Safety
KW - Quality Improvement
KW - Clinical Indicators
KW - Health Services Accessibility
KW - Performance Measurement Systems
KW - Reports
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 70
EP - 71
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 2
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; cclancy@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Edwards, Rufus
AU - Smith, Kirk R.
AU - Kirby, Brent
AU - Allen, Tracy
AU - Litton, Charles D.
AU - Hering, Susanne
T1 - An Inexpensive Dual-Chamber Particle Monitor: Laboratory Characterization.
JO - Journal of the Air & Waste Management Association (Air & Waste Management Association)
JF - Journal of the Air & Waste Management Association (Air & Waste Management Association)
Y1 - 2006/06//
VL - 56
IS - 6
M3 - Article
SP - 789
EP - 799
PB - Air & Waste Management Association
SN - 10962247
AB - In developing countries, high levels of particle pollution from the use of coal and biomass fuels for household cooking and heating are a major cause of ill health and premature mortality. The cost and complexity of existing monitoring equipment, combined with the need to sample many locations, make routine quantification of household particle pollution levels difficult. Recent advances in technology, however, have enabled the development of a small, portable, data-logging particle monitor modified from commercial smoke alarm technology that can meet the needs of surveys in the developing world at reasonable cost. Laboratory comparisons of a prototype particle monitor developed at the University of California at Berkeley (UCB) with gravimetric filters, a tapered element oscillating microbalance, and a TSI DustTrak to quantify the UCB particle monitor response as a function of both concentration and particle size and to examine sensor response in relation to changes in temperature, relative humidity, and elevation are presented here. UCB particle monitors showed good linearity in response to different concentrations of laboratory-generated oleic acid aerosols with a coarse (mass median diameter, 2.1 µm) and fine (mass median diameter, 0.27-0.42 µm) size distributions (average r² = 0.997 ± 0.005). The photoelectric and ionization chamber showed a wide range of responses based on particle size and, thus, require calibration with the aerosol of interest. The ionization chamber was five times more sensitive to fine rather than coarse particles, whereas the photoelectric chamber was five times more sensitive to coarse than fine. The ratio of the response between the two sensors has the potential for mass calibration of individual data points based on estimated parameters of the size distribution. The results demonstrate the significant potential of this monitor, which will facilitate the evaluation of interventions (improved fuels, stoves, and ventilation) on indoor air pollution levels and research on the impacts of indoor particle levels on health in developing countries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Air & Waste Management Association (Air & Waste Management Association) is the property of Air & Waste Management Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution standards
KW - Air quality
KW - Contamination (Technology)
KW - Coal
KW - Fuel
KW - Humidity
KW - Detectors
KW - Nuclear counters
N1 - Accession Number: 21559482; Edwards, Rufus 1,2; Email Address: edwardsr@uci.edu; Smith, Kirk R. 2; Kirby, Brent 3,4; Allen, Tracy 5; Litton, Charles D. 6; Hering, Susanne 4; Affiliations: 1: School of Social Ecology, University of California, Irvine, Irvine, CA; 2: School of Public Health, University of California, Berkeley, Berkeley, CA; 3: Chemistry Department, Princeton University, Princeton, NJ; 4: Aerosol Dynamics, Berkeley, CA; 5: Electronically Monitored Ecosystems (EME), Berkeley, CA; 6: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, PA; Issue Info: Jun2006, Vol. 56 Issue 6, p789; Thesaurus Term: Air pollution standards; Thesaurus Term: Air quality; Thesaurus Term: Contamination (Technology); Thesaurus Term: Coal; Thesaurus Term: Fuel; Thesaurus Term: Humidity; Subject Term: Detectors; Subject Term: Nuclear counters; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 454319 Other fuel dealers; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stein, Stephen E.
AU - Heller, David N.
T1 - On the Risk of False Positive Identification Using Multiple Ion Monitoring in Qualitative Mass Spectrometry: Large-Scale Intercomparisons with a Comprehensive Mass Spectral Library
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2006/06//
VL - 17
IS - 6
M3 - Article
SP - 823
EP - 835
SN - 10440305
AB - Analysts involved in qualitative mass spectrometry have long debated the minimum data requirements for demonstrating that signals from an unknown sample are identical to those from a known compound. Often this process is carried out by comparing a few selected ions acquired by multiple ion monitoring (MIM), with due allowance for expected variability in response. In a few past experiments with electron-ionization mass spectrometry (EI-MS), the number of ions selected and the allowable variability in relative abundance were tested by comparing one spectrum against a library of mass spectra, where library spectra served to represent potential false positive signals in an analysis. We extended these experiments by carrying out large-scale intercomparisons between thousands of spectra and a library of one hundred thousand EI mass spectra. The results were analyzed to gain insights into the identification confidence associated with various numbers of selected ions. A new parameter was investigated for the first time, to take into account that a library spectrum with a different base peak than the search spectrum may still cause a false positive identification. The influence of peak correlation among the specific ions in all the library mass spectra was also studied. Our computations showed that (1) false positive identifications can result from similar compounds, or low-abundance peaks in unrelated compounds if the method calls for detection at very low levels; (2) a MIM method’s identification confidence improves in a roughly continuous manner as more ions are monitored, about one order of magnitude for each additional ion selected; (3) full scan spectra still represent the best alternative, if instrument sensitivity is adequate. The use of large scale intercomparisons with a comprehensive library is the only way to provide direct evidence in support of these conclusions, which otherwise depend on the judgment and experience of individual analysts. There are implications for residue chemists who would rely on standardized confirmation criteria to assess the validity of a given confirmatory method. For example, standardized confirmation criteria should not be used in the absence of interference testing and rational selection of diagnostic ions. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASS spectrometry
KW - MATTER -- Properties
KW - ELECTROLYSIS
KW - SPECTRUM analysis
N1 - Accession Number: 20822049; Stein, Stephen E. 1; Email Address: steve.stein@nist.gov Heller, David N. 2; Affiliation: 1: National Institute of Standards and Technology, Gaithersburg, Maryland, USA 2: FDA Center for Veterinary Medicine, Laurel, Maryland, USA; Source Info: Jun2006, Vol. 17 Issue 6, p823; Subject Term: MASS spectrometry; Subject Term: MATTER -- Properties; Subject Term: ELECTROLYSIS; Subject Term: SPECTRUM analysis; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.jasms.2006.02.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kanj, R. S.
AU - Kang, J. L.
AU - Castranova, V.
T1 - Interaction Between Primary Alveolar Macrophages and Primary Alveolar Type II Cells Under Basal Conditions and After Lipopolysaccharide Or Quartz Exposure.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2006/06//
VL - 69
IS - 11
M3 - Article
SP - 1097
EP - 1116
SN - 15287394
AB - Intercellular communications between alveolar macrophages (AM) and alveolar epithelial type II (TII) cells have been suggested to be important in cellular responses. The main objective of this study was to improve our understanding of the interactions between AM and TII cells that might occur in the lung. In the present investigation, this interaction was studied under different interaction conditions (transwell or mixed coculture) and different exposure conditions (basal, lipopolysaccharide [LPS] exposure, or silica exposure). Studies also attempted different approaches to identify specific mediator(s) involved in this interaction. The following findings were made: (1) Surfactant released from TII cells appears to exert an inhibitory effect on AM activity. (2) Basal transwell coculture conditions are better than mixed coculture conditions to study AM/TII cell interactions, since the inhibitory effect of the surfactant in the transwell coculture is minimized. (3) AM/TII cell interaction is dependent on cell culture (transwell vs mixed) and exposure conditions. (4) Oxidants, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, prostaglandins, and leukotrienes probably do not independently affect the AM/TII intercellular interaction; instead, they appear to indirectly modulate the complex pathways of AM/TII communication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - CELLS
KW - CELL interaction (Biology)
KW - ENDOTOXINS
KW - TUMOR necrosis factor
KW - OXIDIZING agents
KW - CYTOKINES
KW - GROWTH factors
KW - CELL culture
N1 - Accession Number: 20917490; Kanj, R. S. 1,2 Kang, J. L. 3 Castranova, V. 1,2; Email Address: vicl@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA 2: West Virgina University School of Medicine, Department of Physiology and Pharmacology, Morgantown, West Virginia, USA 3: Department of Physiology, Division of Cell Biology, Ewha Womans University, College of Medicine, Seoul, South Korea; Source Info: Jun2006, Vol. 69 Issue 11, p1097; Subject Term: MACROPHAGES; Subject Term: CELLS; Subject Term: CELL interaction (Biology); Subject Term: ENDOTOXINS; Subject Term: TUMOR necrosis factor; Subject Term: OXIDIZING agents; Subject Term: CYTOKINES; Subject Term: GROWTH factors; Subject Term: CELL culture; Number of Pages: 20p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1080/14736480500360504
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106118248
T1 - The effects of state parity laws on the use of mental health care.
AU - Harris KM
AU - Carpenter C
AU - Bao Y
Y1 - 2006/06//
N1 - Accession Number: 106118248. Language: English. Entry Date: 20070713. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: SAMHSA's Office of Applied Studies. NLM UID: 0230027.
KW - Health Services Accessibility -- Legislation and Jurisprudence
KW - Insurance -- Legislation and Jurisprudence
KW - Insurance, Health -- Legislation and Jurisprudence
KW - Mental Health Services -- Legislation and Jurisprudence
KW - Mental Health Services -- Utilization
KW - Adolescence
KW - Adult
KW - Antipsychotic Agents -- Administration and Dosage
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Drug Utilization
KW - Funding Source
KW - Government
KW - Multivariate Analysis
KW - Outpatients
KW - P-Value
KW - Quasi-Experimental Studies
KW - Human
SP - 499
EP - 505
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: We used a quasiexperimental research design to measure the effect of state parity laws on the use of mental health care in the past year. METHODS: We pooled cross-sectional data from the 2001, 2002, and 2003 National Surveys on Drug Use and Health. Our sample included 83,531 adults 18 years of age or over with private health insurance stratified by the level of mental and emotional distress experienced in the worst month of the past year. We used a state and year-fixed effects approach to measure the effect of parity. Similar to a difference-in-difference analysis, the effect of parity was measured by comparing pre-/postchanges in mental health service use within states that switched active parity status to changes in service use within states that did not change parity status in the same calendar year. For each subgroup, we report predictions of the percentage point change in any mental health care use, prescription drug use, and outpatient care use resulting from parity laws. RESULTS: Depending on the time window used to define active parity status, we found that parity increased the probability of using any mental health care in the past year by as much as 1.2 percentage points (P<0.01) for the lower distress group and by as much as 1.8 percentage points (P<0.05) in the middle distress group. We found no statistically significant changes in service use for the upper distress group. Whether measured differences were attributable to changes in the use of prescription drug or outpatient care also depended on the definition of active parity status. CONCLUSIONS: Overall, the results of this study suggest that state parity laws succeeded in expanding access to mental health care for those with relatively mild mental health problems.
SN - 0025-7079
AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA. kharris@rand.org
U2 - PMID: 16707997.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106118248&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Friedman, Bernard
AU - Jiang, H. Joanna
AU - Elixhauser, Anne
AU - Segal, Andrew
T1 - Hospital Inpatient Costs for Adults with Multiple Chronic Conditions.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2006/06//
VL - 63
IS - 3
M3 - Article
SP - 327
EP - 346
SN - 10775587
AB - This article offers national estimates of the proportions of hospital inpatient cases and cost for adult, nonmaternal patients who have multiple chronic conditions. The authors employ a refined classification of chronic versus acute conditions, collapsed to no more than one condition per distinct category of condition. The number of different chronic conditions provides a simple measure of complexity, differing from measures of severity of illness that pertain to a particular episode of treatment. A multivariate regression finds that the number of chronic conditions is an independent influence on hospital cost per case, controlling for other key determinants. Patients with complex illness (e.g., 3+ or 5+ chronic conditions) have a disproportionately large effect on hospital cost per year. The identification of patients in the hospital with complex illness can help in targeting new covered services in a health plan or in risk adjusting health plan premiums. Current policies and demonstrations for the Medicare program may not be sufficient to address complex illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL wards
KW - PATIENTS
KW - MEDICAL care costs
KW - PUBLIC health
KW - HEALTH planning
KW - NATIONAL health insurance
KW - CHRONIC diseases
KW - chronic conditions
KW - hospital cost
N1 - Accession Number: 21094258; Friedman, Bernard 1 Jiang, H. Joanna 1 Elixhauser, Anne 1 Segal, Andrew 2; Affiliation: 1: Agency for Healthcare Research and Quality 2: Columbia University; Source Info: Jun2006, Vol. 63 Issue 3, p327; Subject Term: HOSPITAL wards; Subject Term: PATIENTS; Subject Term: MEDICAL care costs; Subject Term: PUBLIC health; Subject Term: HEALTH planning; Subject Term: NATIONAL health insurance; Subject Term: CHRONIC diseases; Author-Supplied Keyword: chronic conditions; Author-Supplied Keyword: hospital cost; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 20p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1177/1077558706287042
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Butaye, Patrick
AU - Michael, Geovana B.
AU - Schwarz, Stefan
AU - Barrett, Timothy J.
AU - Brisabois, Anne
AU - White, David G.
T1 - The clonal spread of multidrug-resistant non-typhi Salmonella serotypes
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/06//
VL - 8
IS - 7
M3 - Article
SP - 1891
EP - 1897
SN - 12864579
AB - Abstract: Non-typhoid Salmonella are one of the most important organisms causing food-borne diseases worldwide. There have been significant increases in developed countries in recent years in the occurrence of resistance, in particular multidrug resistance phenotypes, in non-typhoid Salmonella spp. Such increases have been observed in many countries, not only within the European community but also the Americas and Southeast Asia. Of particular concern is the increasing detection of Salmonella isolates displaying resistance to key antimicrobials, notably fluoroquinolones and third-generation cephalosporins. An important factor associated with this increase in multidrug resistance among particular Salmonella spp. is the national and international spread of certain clonal genotypes, the most recent being the global epidemic spread of multidrug-resistant S. Typhimurium DT104, since the early 1990s. In this review, we describe examples where particular antimicrobial-resistant Salmonella serotypes emerged, persisted for periods of time, and then quickly decreased in prevalence. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Foodborne diseases
KW - Anti-infective agents
KW - Drug resistance
KW - Antibiotic
KW - Epidemiology
KW - Resistance
N1 - Accession Number: 21830531; Butaye, Patrick 1; Email Address: pabut@var.fgov.be; Michael, Geovana B. 2; Schwarz, Stefan 2; Barrett, Timothy J. 3; Brisabois, Anne 4; White, David G. 5; Affiliations: 1: CODA-CERVA-VAR, Veterinary and Agrochemical Research Centre, Groeselenberg 99, 1180 Brussels, Belgium; 2: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Höltystrasse 10, 31535 Neustadt-Mariensee, Germany; 3: Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: Unité Caractérisation et Epidémiologie Bactérienne, Agence Française de Sécurité Sanitaire des Aliments, Maisons-Alfort, France; 5: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA; Issue Info: Jun2006, Vol. 8 Issue 7, p1891; Thesaurus Term: Salmonella; Thesaurus Term: Foodborne diseases; Thesaurus Term: Anti-infective agents; Subject Term: Drug resistance; Author-Supplied Keyword: Antibiotic; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Resistance; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.micinf.2005.12.020
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Arlet, Guillaume
AU - Barrett, Timothy J.
AU - Butaye, Patrick
AU - Cloeckaert, Axel
AU - Mulvey, Michael R.
AU - White, David G.
T1 - Salmonella resistant to extended-spectrum cephalosporins: prevalence and epidemiology
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/06//
VL - 8
IS - 7
M3 - Article
SP - 1945
EP - 1954
SN - 12864579
AB - Abstract: Salmonella resistant to extended-spectrum cephalosporins (ESCs) have emerged worldwide since 1988. By 2004, 43 countries had reported this public health problem. Resistance was mediated by classical extended-spectrum β-lactamases, plasmid-mediated cephalosporinases, and recently a class A carbapenemase. Of these, CMY-2 is the most widely disseminated enzyme. Salmonella enterica serotype Typhimurium and S. enterica serotype Enteritidis are the most common serovars associated with ESC resistance in human infections. Many outbreaks in humans have been reported, most often among children and neonates. ESC-resistant Salmonella is frequently recovered from animals and food, with poultry as primary food source, suggesting that humans are often infected by these routes. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cephalosporins
KW - Beta lactamases
KW - Salmonella enteritidis
KW - Salmonella typhimurium
KW - Antibiotic resistance
KW - Extended-spectrum cephalosporins
KW - Salmonella
N1 - Accession Number: 21830537; Arlet, Guillaume 1; Email Address: guillaume.arlet@tnn.aphp.fr; Barrett, Timothy J. 2; Butaye, Patrick 3; Cloeckaert, Axel 4; Mulvey, Michael R. 5; White, David G. 6; Affiliations: 1: Departement de Bacteriologie, UPRES EA2392, Faculté de Médecine Pierre et Marie Curie, 27 rue de Chaligny, 75012 Paris, France; 2: Centers for Disease Control and Prevention, 1600 Clifton Road, MS C03, Atlanta, GA 30333, USA; 3: Department of Bacteriology and Immunology, Veterinary and Agrochemical Research Centre, VAR-CODA-CERVA, Groeselenberg 99, B-1180 Ukkel, Belgium; 4: Unite BioAgresseurs, Sante, Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France; 5: Antimicrobial Resistance and Nosocomial Infections, National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada; 6: U.S. Food and Drug Administration, Center for Veterinary Medicine, Division of Animal and Food Microbiology, 8401 Muirkirk Road, Laurel, MD 20708, USA; Issue Info: Jun2006, Vol. 8 Issue 7, p1945; Subject Term: Cephalosporins; Subject Term: Beta lactamases; Subject Term: Salmonella enteritidis; Subject Term: Salmonella typhimurium; Author-Supplied Keyword: Antibiotic resistance; Author-Supplied Keyword: Extended-spectrum cephalosporins; Author-Supplied Keyword: Salmonella; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.micinf.2005.12.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21830537&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zhang, Qijing
AU - Sahin, Orhan
AU - McDermott, Patrick F.
AU - Payot, Sophie
T1 - Fitness of antimicrobial-resistant Campylobacter and Salmonella
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/06//
VL - 8
IS - 7
M3 - Article
SP - 1972
EP - 1978
SN - 12864579
AB - Abstract: Campylobacter and Salmonella are the most commonly reported bacterial causes of human foodborne infections, and increasing proportions of these pathogens become resistant to medically important antimicrobial agents, imposing a burden on public health. Acquisition of resistance to antibiotics affects the adaptation and evolution of Salmonella and Campylobacter in various environments. Many resistance-conferring mutations entail a biological fitness cost, while others (e.g. fluoroquinolone resistance in Campylobacter) have no cost or even enhanced fitness. In Salmonella, the fitness disadvantage due to antimicrobial resistance can be restored by acquired compensatory mutations, which occur both in vitro and in vivo. The compensated or even enhanced fitness associated with antibiotic resistance may facilitate the spread and persistence of antimicrobial-resistant Salmonella and Campylobacter in the absence of selection pressure, creating a significant barrier for controlling antibiotic-resistant foodborne pathogens. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter
KW - Salmonella
KW - Anti-infective agents
KW - Drug resistance
KW - Adaptation
KW - Antimicrobial resistance
KW - Fitness
KW - Fluoroquinolone
N1 - Accession Number: 21830540; Zhang, Qijing 1; Email Address: zhang123@iastate.edu; Sahin, Orhan 2; McDermott, Patrick F. 3; Payot, Sophie 4; Affiliations: 1: Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA; 2: Department of Microbiology, Veterinary Faculty, Mustafa Kemal University, Hatay 31034, Turkey; 3: U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708 USA; 4: Institut National de la Recherche Agronomique, UR086 BioAgresseurs, Santé, Environnement, 37380 Nouzilly, France; Issue Info: Jun2006, Vol. 8 Issue 7, p1972; Thesaurus Term: Campylobacter; Thesaurus Term: Salmonella; Thesaurus Term: Anti-infective agents; Subject Term: Drug resistance; Author-Supplied Keyword: Adaptation; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Fitness; Author-Supplied Keyword: Fluoroquinolone; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.micinf.2005.12.031
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Courtney, Shannon
AU - Mossoba, Miriam E.
AU - Hammack, Thomas S.
AU - Keys, Christine
AU - Al-Khaldi, Sufian F.
T1 - Using PCR amplification to increase the confidence level of Salmonella typhimurium DNA microarray chip hybridization
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2006/06//
VL - 20
IS - 3/4
M3 - Article
SP - 163
EP - 171
SN - 08908508
AB - Abstract: In order to design and validate a method to identify virulence genes of Salmonella typhimurium using DNA microarray, a protocol was developed to label the isolated bacterial DNA directly and to use PCR amplification of limited numbers of genes to validate the hybridization signals. Therefore, a DNA microarray chip of 71 virulence genes of S. typhimurium was developed and evaluated using 10 isolates. Each gene was represented by 65bp oligonucleotide probes (oligoprobes) and immobilized on the surface of chemically modified slides. Whole DNA genomes were digested with Hinf1 and Sau3AI, labeled with a fluorescent tag of Cy3 and then hybridized. The presence of virulence genes in 10 strains of S. typhimurium was established by measuring a fluorescent signal above the background noise of the chip. PCR amplification of 10 genes (orgA, ORF319, ttrB, rmbA, misL, spi4F, spi4H, spi4N, rRNA, and purR) of S. typhimurium was used as a standard to verify the confidence level of the DNA microarray chip. In conclusion, using PCR amplification to increase the confidence level of the microarray hybridization data was successful. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA typhimurium
KW - DNA microarrays
KW - MEDICAL protocols
KW - POLYMERASE chain reaction
KW - DNA microarray
KW - PCR
KW - Salmonella typhimurium
N1 - Accession Number: 20768263; Courtney, Shannon 1 Mossoba, Miriam E. Hammack, Thomas S. 1 Keys, Christine 1 Al-Khaldi, Sufian F.; Email Address: sufian.alkhaldi@fda.hhs.gov; Affiliation: 1: HFS-517, Division of Microbiological Studies, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA; Source Info: Jun2006, Vol. 20 Issue 3/4, p163; Subject Term: SALMONELLA typhimurium; Subject Term: DNA microarrays; Subject Term: MEDICAL protocols; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Salmonella typhimurium; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mcp.2005.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shi, Hang
AU - Rojas, Raul
AU - Bonifacino, Juan S
AU - Hurley, James H
T1 - The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2006/06//
VL - 13
IS - 6
M3 - Article
SP - 540
EP - 548
PB - Nature Publishing Group
SN - 15459993
AB - The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-Å resolution reveals two curved β-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235–246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR biology
KW - LYSOSOMES
KW - ENZYMES
KW - PROTEIN conformation
KW - PHYLOGENY
N1 - Accession Number: 21064291; Shi, Hang 1,2 Rojas, Raul 3 Bonifacino, Juan S 3 Hurley, James H 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA 2: The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA 3: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA; Source Info: Jun2006, Vol. 13 Issue 6, p540; Subject Term: MOLECULAR biology; Subject Term: LYSOSOMES; Subject Term: ENZYMES; Subject Term: PROTEIN conformation; Subject Term: PHYLOGENY; Number of Pages: 9p; Illustrations: 8 Color Photographs, 14 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/nsmb1103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cox, Shanna
AU - Posner, Samuel F.
AU - McPheeters, Melissa
AU - Jamieson, Denise J.
AU - Kourtis, Athena P.
AU - Meikle, Susan
T1 - Hospitalizations With Respiratory Illness Among Pregnant Women During Influenza Season.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2006/06//
VL - 107
IS - 6
M3 - Article
SP - 1315
EP - 1322
SN - 00297844
AB - The article investigates hospitalizations with respiratory illness among pregnant women in the United States during periods of influenza activity. Results reveal that hospitalizations with respiratory illness among pregnant women during influenza season are related to increased burden for patients and the health care system. These women had longer lengths of hospitalization and higher odds of delivery complications than hospitalized pregnant women without respiratory illness.
KW - RESPIRATORY diseases in women
KW - PREGNANT women
KW - HOSPITAL care
KW - INFLUENZA
KW - RESPIRATORY diseases
KW - UNITED States
N1 - Accession Number: 23366039; Cox, Shanna 1 Posner, Samuel F. 1; Email Address: shp5@cdc.gov McPheeters, Melissa 1 Jamieson, Denise J. 1 Kourtis, Athena P. 1 Meikle, Susan 1; Affiliation: 1: Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee; Division of General Pediatrics, the University of Michigan Health System, Ann Arbor, Michigan; and Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Jun2006, Vol. 107 Issue 6, p1315; Subject Term: RESPIRATORY diseases in women; Subject Term: PREGNANT women; Subject Term: HOSPITAL care; Subject Term: INFLUENZA; Subject Term: RESPIRATORY diseases; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hirtz, Deborah G.
AU - Gilbert, Peter R.
AU - Terrill, Cindy M.
AU - Buckman, ShaAvhree Y.
T1 - Clinical Trials in Children—How Are They Implemented?
JO - Pediatric Neurology
JF - Pediatric Neurology
Y1 - 2006/06//
VL - 34
IS - 6
M3 - Article
SP - 436
EP - 438
SN - 08878994
AB - Drug metabolism in children may differ from adults and adverse events may occur that are not predictable from the adult experience. Clinical trials of safety and efficacy are needed both for new treatments and those that may already be in use but have not been tested in infants and children. The role and responsibilities of different participants in a trial are discussed, including the steering committee, the clinical and statistical co-ordinating centers, and the data and safety monitoring board. Advantages of external vs internal pilot studies are reviewed. Information that is available on the websites of the Food and Drug Administration and the National Institute of Neurological Disorders and Stroke may be helpful to those planning clinical trials of interventions in children. [Copyright &y& Elsevier]
AB - Copyright of Pediatric Neurology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG metabolism
KW - CLINICAL trials
KW - PEDIATRIC physiology
KW - MEDICAL research
N1 - Accession Number: 21263313; Hirtz, Deborah G. 1; Email Address: hirtzd@ninds.nih.gov Gilbert, Peter R. 1 Terrill, Cindy M. 2 Buckman, ShaAvhree Y. 3; Affiliation: 1: National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, Maryland 2: Washington University School of Medicine, St. Louis, Missouri 3: OCTAP-Division of Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: Jun2006, Vol. 34 Issue 6, p436; Subject Term: DRUG metabolism; Subject Term: CLINICAL trials; Subject Term: PEDIATRIC physiology; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.pediatrneurol.2005.09.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malek, Mark A.
AU - Curns, Aaron T.
AU - Holman, Robert C.
AU - Fischer, Thea K.
AU - Bresee, Joseph S.
AU - Glass, Roger I.
AU - Steiner, Claudia A.
AU - Parashar, Umesh D.
T1 - Diarrhea- and Rotavirus-Associated Hospitalizations Among Children Less Than 5 Years of Age: United States, 1997 and 2000.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/06//
VL - 117
IS - 6
M3 - Article
SP - 1887
EP - 1892
SN - 00314005
AB - OBJECTIVE. A new rotavirus vaccine may be licensed in the United States in early 2006. Estimates of the burden of severe rotavirus disease, particularly hospitalizations, will help evaluate the potential benefits of a national rotavirus immunization program. DESIGN. The Kids' Inpatient Database, a robust sample of 10% of the uncomplicated births and 80% of other pediatric discharges was used to estimate the number and rate of diarrhea- and rotavirus-associated hospitalizations among US children <5 years of age in 1997 and 2000. RESULTS. In 1997 and 2000, diarrhea was coded in 13% of all childhood hospitalizations, for an estimated cumulative incidence of 1 diarrhea hospitalization per 23 to 27 children by age 5. Most diarrhea-associated hospitalizations (62%) were coded as unspecified etiology, and 35% as viral. Rotavirus was the most common pathogen recorded for 18% and 19% of diarrhea-associated hospitalizations in 1997 and 2000, respectively. Diarrhea-associated hospitalizations coded as unspecified or viral exhibited a marked winter peak similar to that of hospitalizations coded as rotavirus, suggesting that the rotavirus-specific code captures a fraction of all rotavirus hospitalizations. Using indirect methods, we estimated that rotavirus was associated with 51 142-60 155 and 46 839-56 820 hospitalizations in 1997 and 2000, respectively. By these estimates, rotavirus is associated With 4% to 5% of all childhood hospitalizations, and 1 in 67 to 1 in 85 children will be hospitalized with rotavirus by 5 years of age. CONCLUSIONS. Diarrhea is an important cause of hospitalization in US children, and rotavirus is the most important etiology. Disease burden estimates have remained stable during the past decade. An effective rotavirus vaccine will likely reduce substantially the burden of severe rotavirus disease, estimated to account for 4% to 5% of all hospitalizations and ∼30% of hospitalizations for watery diarrhea among children <5 years of age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - REOVIRUSES
KW - IMMUNIZATION
KW - DIARRHEA
KW - JUVENILE diseases
KW - diarrhea
KW - gastroenteritis
KW - hospitalization
KW - rotavirus
KW - vaccines
N1 - Accession Number: 23321372; Malek, Mark A. 1; Email Address: mmalek@cdc.gov Curns, Aaron T. 2 Holman, Robert C. 2 Fischer, Thea K. 1 Bresee, Joseph S. 1 Glass, Roger I. 1 Steiner, Claudia A. 3 Parashar, Umesh D. 1; Affiliation: 1: Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Office of Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Healthcare Cost and Utilization Project, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, Maryland; Source Info: Jun2006, Vol. 117 Issue 6, p1887; Subject Term: ROTAVIRUSES; Subject Term: REOVIRUSES; Subject Term: IMMUNIZATION; Subject Term: DIARRHEA; Subject Term: JUVENILE diseases; Author-Supplied Keyword: diarrhea; Author-Supplied Keyword: gastroenteritis; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: rotavirus; Author-Supplied Keyword: vaccines; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1542/peds.2005-2351
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seligman, Paul J.
T1 - Thinking outside the (black) box: a new research agenda.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2006/06//
VL - 15
IS - 6
M3 - Article
SP - 387
EP - 389
SN - 10538569
N1 - Accession Number: 64708899; Seligman, Paul J. 1; Affiliations: 1: Office of Pharmacoepidemiology and Statistical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Jun2006, Vol. 15 Issue 6, p387; Number of Pages: 3p; Document Type: Article
L3 - 10.1002/pds.1205
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ER -
TY - JOUR
AU - Nourjah, Parivash
AU - Ahmad, Syed Rizwanuddin
AU - Karwoski, Claudia
AU - Willy, Mary
T1 - Estimates of acetaminophen (paracetomal)-associated overdoses in the United States.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2006/06//
VL - 15
IS - 6
M3 - Article
SP - 398
EP - 405
SN - 10538569
AB - Objective To estimate the number of acetaminophen-associated overdoses in the United States and identify possible risk factors for intervention. Methods The investigators obtained estimates of acetaminophen-associated overdoses using different national databases. Two emergency room databases, a hospital discharge database, a national mortality file, and a poison surveillance database were used to identify cases. The FDA's spontaneous reporting system was searched to identify possible root causes for overdoses. Results Analysis of national databases show that acetaminophen-associated overdoses account for about 56 000 emergency room visits and 26 000 hospitalizations yearly. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional. The poison surveillance database showed near-doubling in the number of fatalities associated with acetaminophen from 98 in 1997 to 173 in 2001. AERS data describe a number of possible causes for unintentional acetaminophen-associated overdoses. Conclusions Each year a substantial numbers of Americans experience intentional and unintentional acetaminophen-associated overdoses that, in severe cases, lead to serious illness and possible death. This summary of a series of analyses highlights the need for strategies to reduce this public health burden. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708904; Nourjah, Parivash 1; Ahmad, Syed Rizwanuddin 1; Karwoski, Claudia 1; Willy, Mary 1; Affiliations: 1: Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Issue Info: Jun2006, Vol. 15 Issue 6, p398; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1191
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ER -
TY - JOUR
AU - Szarfman, Ana
AU - Tonning, Joseph M.
AU - Levine, Jonathan G.
AU - Doraiswamy, P. Murali
T1 - Atypical Antipsychotics and Pituitary Tumors: A Pharmacovigilance Study.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2006/06//
VL - 26
IS - 6
M3 - Article
SP - 748
EP - 758
SN - 02770008
AB - Study Objective. To analyze the disproportionality of reporting of hyperprolactinemia, galactorrhea, and pituitary tumors with seven widely used antipsychotic drugs. Design. Retrospective pharmacovigilance study. Data Source. United States Food and Drug Administration's Adverse Event Reporting System (AERS) database. Intervention. We initially identified higher-than-expected postmarketing reports of pituitary tumors associated with risperidone, a potent dopamine D2-receptor antagonist antipsychotic, by analyzing reporting patterns of these tumors in the AERS database. To further examine this association, we analyzed disproportionate reporting patterns of pituitary tumor reports for seven antipsychotics with different affinities for blocking D2 receptors: aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, and haloperidol. Measurements and Main Results. To conduct both of these analyses, we used the Multi-item Gamma Poisson Shrinker (MGPS) data mining algorithm applied to the AERS database. The MGPS uses a Bayesian model to calculate adjusted observed: expected ratios of drug-adverse event associations (Empiric Bayes Geometric Mean [EBGM] values) in huge drug safety databases. The higher the adjusted reporting ratio, or EBGM value, the greater the strength of the association between a drug and an adverse event. Risperidone had the highest adjusted reporting ratios for hyperprolactinemia (EBGM 34.9, 90% confidence interval [CI] 32.8-37.1]), galactorrhea (EBGM 19.9, 90% CI 18.6-21.4), and pituitary tumor (EBGM 18.7, 90% CI 14.9-23.3) among the seven antipsychotics, and one of the highest scores for all drugs in the AERS database. Some tumors were associated with visual field defects, hemorrhage, convulsions, surgery; and severe (> 10-fold) prolactin elevations. The EBGM values for risperidone fur these adverse events were higher in women, but high EBGM values for these events were also seen in men and children. Moreover, the rank order of the EBGM values for pituitary tumors corresponded to the affinities of these seven drugs for D2 receptors. Conclusion. Treatment with potent D2-receptor antagonists, such as risperidone, may be associated with pituitary tumors. These findings are consistent with animal (mice) studies and raise the need for clinical awareness and longitudinal studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERPROLACTINEMIA
KW - LACTATION disorders
KW - TUMORS
KW - ANTIPSYCHOTIC drugs
KW - Antipsychotics
KW - data mining
KW - hyperprolactinemia
KW - MGPS
KW - Multi-item Gamma Poisson Shrinker algorithm
KW - pituitary tumors
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 21112196; Szarfman, Ana 1; Email Address: szarfman@cder.fda.gov Tonning, Joseph M. 1 Levine, Jonathan G. 1 Doraiswamy, P. Murali 2; Affiliation: 1: Office of Pharmacoepidemiology and Statistical Sciences, Immediate Office, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 2: Departments of Psychiatry and Medicine, Duke University Medical Center, Durham, North Carolina; Source Info: Jun2006, Vol. 26 Issue 6, p748; Subject Term: HYPERPROLACTINEMIA; Subject Term: LACTATION disorders; Subject Term: TUMORS; Subject Term: ANTIPSYCHOTIC drugs; Author-Supplied Keyword: Antipsychotics; Author-Supplied Keyword: data mining; Author-Supplied Keyword: hyperprolactinemia; Author-Supplied Keyword: MGPS; Author-Supplied Keyword: Multi-item Gamma Poisson Shrinker algorithm; Author-Supplied Keyword: pituitary tumors; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106213039
T1 - Purchaser strategies to influence quality of care: from rhetoric to global applications.
AU - McNamara P
Y1 - 2006/06//
N1 - Accession Number: 106213039. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Contract Services -- Standards
KW - Decision Making, Organizational
KW - Health Care Industry -- Standards
KW - Quality Assurance -- Economics
KW - Reimbursement Mechanisms
KW - Safety
KW - Shared Services, Health Care -- Methods
KW - Contract Services -- Economics
KW - Developing Countries
KW - Government Programs -- Economics
KW - Government Programs -- Standards
KW - Insurance, Health -- Economics
KW - Insurance, Health -- Standards
KW - Organizations
KW - Social Responsibility
KW - Systems Analysis
KW - United States
KW - United States Centers for Medicare and Medicaid Services
SP - 171
EP - 173
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - The potential of purchasers to influence the quality and safety of care has captured the attention of health sector leaders worldwide. Quality based purchasing explicitly seeks to hold providers accountable for the quality and safety of care. Three strategies are available to purchasers: (1) selective contracting based on quality; (2) payment differentials based on quality; and (3) sponsorship of comparative provider report cards. Examples are given to illustrate each of the three strategies. Governments, employers, social insurance funds, community based insurance organizations, health plans, donors, and other buyers of health services are encouraged to explore and debate these purchaser strategies within the context of an overarching national or local quality framework. Public and private funders of operations research are encouraged to support and disseminate evaluations of purchaser efforts to improve quality. This paper is designed to highlight and frame purchasers' strategies explicitly crafted to enhance the quality and safety of care. The ultimate aim is to encourage thoughtful discussion about whether or not one or more purchaser strategy might support a particular country's goals to improve care. Experiences from both developed and developing countries are included to facilitate the exchange of ideas and provide the broadest of perspectives.
SN - 1475-3898
AD - Center for Delivery, Organization and Markets, US Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. pmcnamar@ahrq.gov.
U2 - PMID: 16751465.
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DB - rzh
ER -
TY - JOUR
AU - Perrin-Guyomard, Agnès
AU - Poul, Jean-Michel
AU - Laurentie, Michel
AU - Sanders, Pascal
AU - Fernández, A. Haydée
AU - Bartholomew, Mary
T1 - Impact of ciprofloxacin in the human-flora-associated (HFA) rat model: Comparison with the HFA mouse model
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/06//
VL - 45
IS - 1
M3 - Article
SP - 66
EP - 78
SN - 02732300
AB - Abstract: The ecological impact of different doses of ciprofloxacin was investigated in an experimental germ-free rat model into which human fecal flora was inoculated. Animals received oral doses (gavage) of 0, 0.25, 2.5, and 25mg/kg body weight (bw) of ciprofloxacin once daily for 5 weeks. All doses of ciprofloxacin significantly reduced aerobic populations. Elimination of Enterobacteriaceae and reduction of bifodibacteria were noticed in the group treated with 25mg/kg of the antibiotic. The rest of the intestinal flora was not affected. These effects were reversible after the treatment ended. The percentage of resistant enterococci increased in rats treated with 2.5 and 25mg/kg; however, this increase was not statistically significant. There was a significant (P <0.05) emergence of ciprofloxacin-resistant Bacteroides fragilis group with 25mg/kg bw, which is equivalent to a human therapeutic dosage of the antibiotic. The MIC values and the percentage of resistance remained elevated 2 weeks after the end of treatment in this anaerobic population. Although sub-populations of enterococci and Enterobacteriaceae showed decreased susceptibility after ciprofloxacin administration, resistance was not evident. The ability of an exogenous strain of Salmonella to colonize the intestine of animals treated with 25mg/kg of ciprofloxacin confirmed that the drug disrupted the colonization barrier effect of the indigenous flora at the high dose level tested. No changes in the metabolic parameters occurred during the antibiotic treatment. The results obtained in the HFA rat model were similar to those obtained in our previous study using the HFA mice model where ciprofloxacin at 0.125, 1.25, and 12.5mg/kg bw induced a decrease of enterococci and Enterobacteriaceae populations. The high dose of ciprofloxacin also induced a decrease in bifidobacteria counts, an increase in levels of resistant B. fragilis group and a significant (P <0.05) disruption of the colonization resistance of the barrier flora in HFA mice. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibiotics
KW - Enterobacteriaceae
KW - Gram-negative bacteria
KW - Ciprofloxacin
KW - Drug residues
KW - Human-flora-associated rodent model
KW - Intestinal flora
N1 - Accession Number: 20656325; Perrin-Guyomard, Agnès 1; Email Address: a.perrin-guyomard@afssa.fr; Poul, Jean-Michel 1; Laurentie, Michel 1; Sanders, Pascal 1; Fernández, A. Haydée 2; Bartholomew, Mary 2; Affiliations: 1: Agence Française de Sécurité Sanitaire des Aliments, Laboratoire d’études et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougères cedex, France; 2: United States Food and Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA; Issue Info: Jun2006, Vol. 45 Issue 1, p66; Thesaurus Term: Antibiotics; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Gram-negative bacteria; Subject Term: Ciprofloxacin; Author-Supplied Keyword: Drug residues; Author-Supplied Keyword: Human-flora-associated rodent model; Author-Supplied Keyword: Intestinal flora; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.02.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, J. J.
AU - Tsai, C.-A.
AU - Moon, H.
AU - Ahn, H.
AU - Young, J. J.
AU - Chen, C.-H.
T1 - Decision threshold adjustment in class prediction.
JO - SAR & QSAR in Environmental Research
JF - SAR & QSAR in Environmental Research
Y1 - 2006/06//
VL - 17
IS - 3
M3 - Article
SP - 337
EP - 352
SN - 1062936X
AB - Standard classification algorithms are generally designed to maximize the number of correct predictions (concordance). The criterion of maximizing the concordance may not be appropriate in certain applications. In practice, some applications may emphasize high sensitivity (e.g., clinical diagnostic tests) and others may emphasize high specificity (e.g., epidemiology screening studies). This paper considers effects of the decision threshold on sensitivity, specificity, and concordance for four classification methods: logistic regression, classification tree, Fisher's linear discriminant analysis, and a weighted k-nearest neighbor. We investigated the use of decision threshold adjustment to improve performance of either sensitivity or specificity of a classifier under specific conditions. We conducted a Monte Carlo simulation showing that as the decision threshold increases, the sensitivity decreases and the specificity increases; but, the concordance values in an interval around the maximum concordance are similar. For specified sensitivity and specificity levels, an optimal decision threshold might be determined in an interval around the maximum concordance that meets the specified requirement. Three example data sets were analyzed for illustrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of SAR & QSAR in Environmental Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONCORDANCES (Topology)
KW - SENSITIVITY theory (Mathematics)
KW - IMMUNOSPECIFICITY
KW - CORRELATION (Statistics)
KW - NEAREST neighbor analysis (Statistics)
KW - Concordance
KW - Cross validation
KW - Receiver operating characteristic curve
KW - Sensitivity & specificity
KW - Weighted k -NN
KW - Weighted k-NN
N1 - Accession Number: 21459909; Chen, J. J. 1; Email Address: jchen@nctr.fda.gov Tsai, C.-A. 2 Moon, H. 1 Ahn, H. 3 Young, J. J. 1 Chen, C.-H. 2; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 2: Institute of Statistical Science, Academia Sinica, Taipei, 11529, Taiwan 3: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, 11794; Source Info: Jun2006, Vol. 17 Issue 3, p337; Subject Term: CONCORDANCES (Topology); Subject Term: SENSITIVITY theory (Mathematics); Subject Term: IMMUNOSPECIFICITY; Subject Term: CORRELATION (Statistics); Subject Term: NEAREST neighbor analysis (Statistics); Author-Supplied Keyword: Concordance; Author-Supplied Keyword: Cross validation; Author-Supplied Keyword: Receiver operating characteristic curve; Author-Supplied Keyword: Sensitivity & specificity; Author-Supplied Keyword: Weighted k -NN; Author-Supplied Keyword: Weighted k-NN; Number of Pages: 16p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10659360600787700
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - LI, QIAN H.
AU - LAGAKOS, STEPHEN W.
T1 - On the Relationship between Directional and Omnibus Statistical Tests.
JO - Scandinavian Journal of Statistics
JF - Scandinavian Journal of Statistics
Y1 - 2006/06//
VL - 33
IS - 2
M3 - Article
SP - 239
EP - 246
PB - Wiley-Blackwell
SN - 03036898
AB - A common statistical problem involves the testing of a K-dimensional parameter vector. In both parametric and semiparametric settings, two types of directional tests – linear combination and constrained tests – are frequently used instead of omnibus tests in hopes of achieving greater power for specific alternatives. In this paper, we consider the relationship between these directional tests, as well as their relationship to omnibus tests. Every constrained directional test is shown to be asymptotically equivalent to a specific linear combination test under a sequence of contiguous alternatives and vice versa. Even when the direction of the alternative is known, the constrained test in general will not be optimal unless the objective function used to derive it is efficient. For an arbitrary alternative, insight into the power characteristics of directional tests in comparison to omnibus tests can be gained by a chi-square partition of the omnibus test. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Statistics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL hypothesis testing
KW - ASYMPTOTIC distribution (Probability theory)
KW - CHI-squared test
KW - LINEAR models (Statistics)
KW - MATHEMATICAL statistics
KW - asymptotic equivalence
KW - chi-square partition
KW - constrained tests
KW - directional tests
KW - linear combination tests
KW - omnibus tests
N1 - Accession Number: 20620615; LI, QIAN H. 1; Email Address: liq@cder.fda.gov LAGAKOS, STEPHEN W. 2; Affiliation: 1: Center for Drug Evaluation and Research, US Food and Drug Administration 2: Department of Biostatistics, Harvard School of Public Health; Source Info: Jun2006, Vol. 33 Issue 2, p239; Subject Term: STATISTICAL hypothesis testing; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: CHI-squared test; Subject Term: LINEAR models (Statistics); Subject Term: MATHEMATICAL statistics; Author-Supplied Keyword: asymptotic equivalence; Author-Supplied Keyword: chi-square partition; Author-Supplied Keyword: constrained tests; Author-Supplied Keyword: directional tests; Author-Supplied Keyword: linear combination tests; Author-Supplied Keyword: omnibus tests; Number of Pages: 8p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1111/j.1467-9469.2005.00489.x
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DP - EBSCOhost
DB - aph
ER -
TY - CASE
AU - Götz, Hannelore M.
AU - Veldhuijzen, Irene K.
AU - Habbema, J. Dik F.
AU - Boeke, A. Joan P.
AU - Richardus, Jan Hendrik
AU - Steyerberg, Ewout W.
T1 - Prediction of Chiamydia trachomatis Infection: Application of a Scoring Rule to Other Populations.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2006/06//
VL - 33
IS - 6
M3 - Case Study
SP - 374
EP - 380
SN - 01485717
AB - The article presents a case study that validates the prediction rule used in screening chlamydia trachomatis infection by considering respondents at ages 15-29 years old from Amsterdam and Rotterdam in the Netherlands. Validity was indicated through discriminative ability and calibration. Results shows that chlamydia prediction rule has a reasonable external validity in two studies. Furthermore, it considers that a scoring rule is a significant tool for screening chlamydia trachomatis.
KW - MEDICAL screening
KW - CHLAMYDIA infections
KW - SEXUALLY transmitted diseases
KW - BACTERIAL diseases
KW - NETHERLANDS
N1 - Accession Number: 21089756; Götz, Hannelore M. 1,2; Email Address: gotzh@ggd.rotterdam.nl Veldhuijzen, Irene K. 1 Habbema, J. Dik F. 2 Boeke, A. Joan P. 3 Richardus, Jan Hendrik 1,2 Steyerberg, Ewout W. 2; Affiliation: 1: Rotterdam Public Health Service, Rotterdam, Netherlands 2: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands 3: Department of General Practice, Institute for Research in Extramural Medicine (EMGO), VU University Medical Center, Amsterdam, Netherlands; Source Info: Jun2006, Vol. 33 Issue 6, p374; Subject Term: MEDICAL screening; Subject Term: CHLAMYDIA infections; Subject Term: SEXUALLY transmitted diseases; Subject Term: BACTERIAL diseases; Subject Term: NETHERLANDS; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 7p; Illustrations: 3 Charts, 3 Graphs; Document Type: Case Study
L3 - 10.1097/01.olq.0000194585.82456.51
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106353039
T1 - Prediction of Chlamydia trachomatis infection: application of a scoring rule to other populations.
AU - Götz HM
AU - Veldhuijzen IK
AU - Habbema JDF
AU - Boeke AJP
AU - Richardus JH
AU - Steyerberg EW
Y1 - 2006/06//
N1 - Accession Number: 106353039. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7705941.
KW - Chlamydia Infections -- Epidemiology
KW - Chlamydia Infections -- Transmission
KW - Chlamydia Trachomatis
KW - Disease Transmission, Horizontal
KW - Adolescence
KW - Adult
KW - Chlamydia Infections -- Etiology
KW - Chlamydia Infections -- Urine
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Effect Size
KW - Female
KW - Male
KW - Models, Statistical
KW - Netherlands
KW - Odds Ratio
KW - P-Value
KW - Predictive Value of Tests
KW - Probability
KW - Questionnaires
KW - Regression
KW - ROC Curve
KW - Sensitivity and Specificity
KW - Urban Areas
KW - Human
SP - 374
EP - 380
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 33
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Rotterdam Public Health Service, Rotterdam, The Netherlands; gotzh@ggd.rotterdam.nl
U2 - PMID: 16505746.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rebecca L. Sheets
AU - Judith Stein
AU - T. Scott Manetz
AU - Chris Duffy
AU - Martha Nason
AU - Charla Andrews
AU - Wing-Pui Kong
AU - Gary J. Nabel
AU - Phillip L. Gomez
T1 - Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/06//
VL - 91
IS - 2
M3 - Article
SP - 610
EP - 619
PB - Oxford University Press / USA
SN - 10966080
AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant—IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies have been performed in mice or rabbits to determine where in the body these plasmid vaccines would biodistribute and how rapidly they would clear. In the course of these studies, it has been observed that regardless of the gene insert (expressing the vaccine immunogen or cytokine adjuvant) and regardless of the promoter used to drive expression of the gene insert in the plasmid backbone, the plasmid vaccines do not biodistribute widely and remain essentially in the site of injection, in the muscle and overlying subcutis. Even though ∼ 1014 molecules are inoculated in the studies in rabbits, by day 8 or 9 (∼ 1 week postinoculation), already all but on the order of 104–106 molecules per microgram of DNA extracted from tissue have been cleared at the injection site. Over the course of 2 months, the plasmid clears from the site of injection with only a small percentage of animals (generally 10–20%) retaining a small number of copies (generally around 100 copies) in the muscle at the injection site. This pattern of biodistribution (confined to the injection site) and clearance (within 2 months) is consistent regardless of differences in the promoter in the plasmid backbone or differences in the gene insert being expressed by the plasmid vaccine. In addition, integration has not been observed with plasmid vaccine candidates inoculated i.m. by Biojector 2000 or by needle and syringe. These data build on the repeated-dose toxicology studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccines
KW - United States
KW - National Institute of Allergy & Infectious Diseases (U.S.). Vaccine Research Center
KW - National Institutes of Health (U.S.)
N1 - Accession Number: 20980069; Rebecca L. Sheets 1; Judith Stein 2; T. Scott Manetz 3; Chris Duffy 4; Martha Nason 5; Charla Andrews 6; Wing-Pui Kong 2; Gary J. Nabel 2; Phillip L. Gomez 7; Affiliations: 1: U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628;; 2: Vaccine Research Center/NIAID/NIH, Bethesda, Maryland 20892;; 3: Toxicology Dept., Gene Logic Inc., Gaithersburg, Maryland 20879;; 4: Analytical Services, Althea Technologies, Inc., San Diego, California 92121;; 5: NIH/NIAID, Bethesda, Maryland 20892;; 6: Vaccine Production Program/Regulatory Affairs, Vaccine Research Center/NIAID/NIH, Bethesda, Maryland 20892-3011; and; 7: Vaccine Production, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892-3011; Issue Info: Jun2006, Vol. 91 Issue 2, p610; Subject Term: Vaccines; Subject: United States ; Company/Entity: National Institute of Allergy & Infectious Diseases (U.S.). Vaccine Research Center ; Company/Entity: National Institutes of Health (U.S.); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20980069&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rebecca L. Sheets
AU - Judith Stein
AU - T. Scott Manetz
AU - Charla Andrews
AU - Robert Bailer
AU - John Rathmann
AU - Phillip L. Gomez
T1 - Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/06//
VL - 91
IS - 2
M3 - Article
SP - 620
EP - 630
PB - Oxford University Press / USA
SN - 10966080
AB - The Vaccine Research Center has developed a number of vaccine candidates for different diseases/infectious agents (HIV-1, Severe Acute Respiratory Syndrome virus, West Nile virus, and Ebola virus, plus a plasmid cytokine adjuvant—IL-2/Ig) based on a DNA plasmid vaccine platform. To support the clinical development of each of these vaccine candidates, preclinical studies were performed to screen for potential toxicities (intrinsic and immunotoxicities). All treatment-related toxicities identified in these repeated-dose toxicology studies have been confined primarily to the sites of injection and seem to be the result of both the delivery method (as they are seen in both control and treated animals) and the intended immune response to the vaccine (as they occur with greater frequency and severity in treated animals). Reactogenicity at the site of injection is generally seen to be reversible as the frequency and severity diminished between doses and between the immediate and recovery termination time points. This observation also correlated with the biodistribution data reported in the companion article (Sheets et al., 2006), in which DNA plasmid vaccine was shown to remain at the site of injection, rather than biodistributing widely, and to clear over time. The results of these safety studies have been submitted to the Food and Drug Administration to support the safety of initiating clinical studies with these and related DNA plasmid vaccines. Thus far, standard repeated-dose toxicology studies have not identified any target organs for toxicity (other than the injection site) for our DNA plasmid vaccines at doses up to 8 mg per immunization, regardless of disease indication (i.e., expressed gene-insert) and despite differences (strengths) in the promoters used to drive this expression. As clinical data accumulate with these products, it will be possible to retrospectively compare the safety profiles of the products in the clinic to the results of the repeated-dose toxicology studies, in order to determine the utility of such toxicology studies for signaling potential immunotoxicities or intrinsic toxicities from DNA vaccines. These data build on the biodistribution studies performed (see companion article, Sheets et al., 2006) to demonstrate the safety and suitability for investigational human use of DNA plasmid vaccine candidates for a variety of infectious disease prevention indications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Vaccines
KW - United States
KW - National Institute of Allergy & Infectious Diseases (U.S.). Vaccine Research Center
KW - National Institutes of Health (U.S.)
N1 - Accession Number: 20980070; Rebecca L. Sheets 1; Judith Stein 2; T. Scott Manetz 3; Charla Andrews 4; Robert Bailer 5; John Rathmann 5; Phillip L. Gomez 6; Affiliations: 1: U.S. Public Health Service, Vaccine Production Program, NIH/NIAID/Vaccine Research Center, Bethesda, Maryland 20892-7628;; 2: Vaccine Research Center/NIAID/NIH, Bethesda, Maryland 20892;; 3: Toxicology Dept., Gene Logic Inc., Gaithersburg, Maryland 20879;; 4: Vaccine Production Program/Regulatory Affairs, Vaccine Research Center/NIAID/NIH; Bethesda, Maryland 20892-3011;; 5: Immunology Core Laboratory Section, Vaccine Research Center/NIH/NIAID, Bethesda, Maryland 20892; and; 6: Vaccine Production, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892-3011; Issue Info: Jun2006, Vol. 91 Issue 2, p620; Thesaurus Term: Diseases; Subject Term: Vaccines; Subject: United States ; Company/Entity: National Institute of Allergy & Infectious Diseases (U.S.). Vaccine Research Center ; Company/Entity: National Institutes of Health (U.S.); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 11p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20980070&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steven Cooper
AU - John R. Latendresse
AU - Daniel R. Doerge
AU - Nathan C. Twaddle
AU - Xin Fu
AU - K. Barry Delclos
T1 - Dietary Modulation of p-Nonylphenol–Induced Polycystic Kidneys in Male Sprague-Dawley Rats.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/06//
VL - 91
IS - 2
M3 - Article
SP - 631
EP - 642
PB - Oxford University Press / USA
SN - 10966080
AB - We had previously found that p-nonylphenol (NP) at 1000–2000 ppm in a soy- and alfalfa-free diet induced severe polycystic kidney disease (PKD) in both male and female pups exposed from gestation day 7 through postnatal day (PND) 50 and hypothesized that differences in dietary components contributed to the severity of lesions relative to those reported in other studies using similar doses of NP. The present study investigated the dietary modulation of NP-induced PKD using the same exposure regimen with 2000 ppm NP in four different diets: the natural ingredient soy- and alfalfa-free diet that had been used in the earlier study, Purina 5K96; two defined diets AIN-93G, designated AIN-CAS, and a modified AIN-93G with soy protein isolate replacing casein as the protein source (AIN-SPI); and the commonly used natural ingredient diet Purina 5001 (P5001). Serum isoflavone levels were negligible in animals fed the soy-free AIN-CAS and 5K96 diets and were 2- to 18-fold higher in animals fed P5001 than in those fed AIN-SPI. Consumption of P5001 was significantly greater than consumption of the other diets, and those animals fed P5001 were generally significantly heavier than animals receiving the other diets. NP significantly reduced body weight gain in male pups regardless of the diet fed. There was no evidence of NP-induced kidney toxicity in male pups at PND 2, 14, or 21 or in the dams. In PND 50 male pups, serum blood urea nitrogen was significantly elevated by NP in all diet groups. Urine volume and urinary N-acetyl β-glucuronidase were significantly increased by NP in the soy-free 5K96 and AIN-CAS diet groups. Relative kidney weights were increased by NP in all diet groups except P5001, with the greatest increase in AIN-CAS and 5K96 diet groups. Microscopic evaluation of kidneys from the PND 50 males showed that NP induced PKD in all diet groups but with marked variation in the severity depending on the diet. PKD was severe in 100% of the NP-treated animals in the AIN-CAS and 5K96 groups, moderate in 88% of the AIN-SPI diet group, and mild in only 40% of the P5001 diet group. Thus, diet can significantly modulate the development of PKD induced by dietary NP in rats. Soy components, as well as other complex dietary factors, may account for the level of protection afforded by the P5001 diet. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Kidney diseases
KW - Diet in disease
KW - Urinary organs
KW - Blood plasma
N1 - Accession Number: 20980071; Steven Cooper 1; John R. Latendresse 2; Daniel R. Doerge 1; Nathan C. Twaddle 1; Xin Fu 1; K. Barry Delclos 1; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079;; 2: Toxicologic Pathology Associates, Jefferson, Arkansas 72079; Issue Info: Jun2006, Vol. 91 Issue 2, p631; Subject Term: Kidney diseases; Subject Term: Diet in disease; Subject Term: Urinary organs; Subject Term: Blood plasma; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 12p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=20980071&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106335800
T1 - Facilitators and barriers to employment among individuals with psychiatric disabilities: a job coach perspective.
AU - Blitz CL
AU - Mechanic D
Y1 - 2006/06//
N1 - Accession Number: 106335800. Language: English. Entry Date: 20060922. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Europe; Peer Reviewed; UK & Ireland. Grant Information: Supported in part by a grant from the Disability Research Institute, University of Illinois at Urbana-Champaign. NLM UID: 9204382.
KW - Employment of Disabled -- Evaluation
KW - Mental Disorders -- Rehabilitation
KW - Rehabilitation, Vocational
KW - Sheltered Workshops
KW - Descriptive Statistics
KW - Educational Status
KW - Exploratory Research
KW - Multimethod Studies
KW - Professional Practice, Evidence-Based
KW - Questionnaires
KW - Self Report
KW - Semi-Structured Interview
KW - Funding Source
KW - Human
SP - 407
EP - 419
JO - Work
JF - Work
JA - WORK
VL - 26
IS - 4
PB - IOS Press
AB - Unemployment rates remain high among individuals with psychiatric disabilities despite growing evidence that supported employment programs (SEPs) can help such individuals to obtain and retain competitive employment. A complete understanding of factors that may facilitate or hinder the success of such supported employment efforts is urgently needed to increase the efficacy of SEPs and move more individuals with psychiatric disabilities from welfare to work. This exploratory study provides insight into potential facilitators and barriers to employment among individuals with psychiatric disabilities from the perspective of job coaches. Twenty-eight job coaches from 14 SEPs in a Northeastern state reported on their experience with four recent clients, two who were successful in obtaining employment and two who failed, through a semi-structured mail survey. Findings suggest that job coaches use similar strategies to assist clients, but in each case try to tailor specific strategies to client's needs and characteristics. Factors that influence successful job placement and research and policy implications are discussed.
SN - 1051-9815
AD - Associate Director, Center for Mental Health Services & Criminal Justice Research, Institute for Health, Health Care Policy and Aging Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901; clblitz@rci.rutgers.edu
U2 - PMID: 16788260.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106335800&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-21897-002
AN - 2006-21897-002
AU - Leff, Stephen
AU - Conley, Jeremy
AU - Hennessy, Kevin
T1 - Marketing Behavioral Health: Implications of Evidence Assessments for Behavioral Health Care in the United States.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2006///Sum 2006
VL - 35
IS - 2
SP - 6
EP - 20
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2006-21897-002. Partial author list: First Author & Affiliation: Leff, Stephen; Department of Psychiatry, Harvard Medical School, Boston, MA, US. Other Publishers: Taylor & Francis. Release Date: 20061204. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Health Care Services; Health Care Psychology; Intervention; Measurement. Classification: Health Psychology & Medicine (3360). Population: Human (10). Location: US. References Available: Y. Page Count: 15. Issue Publication Date: Sum 2006.
AB - In this paper we describe intervention science as it applies to psychosocial behavioral health interventions and its effects on the growing evidence assessment infrastructure. In the process we discuss parallels with intervention science in industry and physical healthcare. Emerging government policies in the United States, such as Substance Abuse and Mental Health Services Administration's National Registry of Evidence-Based Programs and Practices, create opportunities for increased commercialization of intervention development and dissemination a trend that contains both opportunities and risks for the field. The opportunities are to improve behavioral health care by devoting resources to rapidly identifying safe and effective interventions and translating these into routine clinical practice. The risks include biased research, limited ranges of services, and higher costs for providers. We also describe methods and mechanisms for controlling risks and promoting improvements, including but not limited to international coordination and cooperation (harmonization). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marketing behavioral health
KW - evidence assessments
KW - behavioral health care
KW - psychosocial interventions
KW - United States
KW - 2006
KW - Evidence Based Practice
KW - Health Care Services
KW - Health Care Psychology
KW - Intervention
KW - Measurement
KW - 2006
DO - 10.2753/IMH0020-7411350201
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21897-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21897-003
AN - 2006-21897-003
AU - Hennessy, Kevin D.
AU - Finkbiner, Richard
AU - Hill, Gary
T1 - The National Registry of Evidence-Based Programs and Practices: A Decision-Support Tool to Advance the Use of Evidence-Based Services.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2006///Sum 2006
VL - 35
IS - 2
SP - 21
EP - 34
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2006-21897-003. Partial author list: First Author & Affiliation: Hennessy, Kevin D.; Office of Policy, Planning and Budget, Substance Abuse and Mental Health Services Administration, US. Other Publishers: Taylor & Francis. Release Date: 20061204. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Drug Abuse Prevention; Evidence Based Practice; Mental Disorders; Mental Health Services. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: Sum 2006.
AB - Since its creation in 1996, the National Registry of Evidence- Based Programs and Practices (NREPP) has provided information to the public about the scientific evidence to support a wide array of substance abuse prevention interventions. In the process of expanding NREPP to the domains of substance abuse treatment and to the prevention and treatment of mental illnesses, the Substance Abuse and Mental Health Services Administration (SAMHSA) has explored a variety of mechanisms to enhance the utility of NREPP for multiple audiences. This paper describes the process employed by SAMHSA to evaluate the informational and decision-support needs of various stakeholder audiences and provides a detailed description of the changes to the NREPP system resulting from this process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - National Registry of Evidence Based Programs and Practices
KW - decision support tool
KW - evidence based services
KW - mental illnesses
KW - substance abuse prevention
KW - 2006
KW - Decision Making
KW - Drug Abuse Prevention
KW - Evidence Based Practice
KW - Mental Disorders
KW - Mental Health Services
KW - 2006
DO - 10.2753/IMH0020-7411350202
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21897-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08878-003
AN - 2006-08878-003
AU - Wagner, Mary
AU - Davis, Maryann
T1 - How Are We Preparing Students With Emotional Disturbances for the Transition to Young Adulthood? Findings From the National Longitudinal Transition Study-2.
JF - Journal of Emotional and Behavioral Disorders
JO - Journal of Emotional and Behavioral Disorders
JA - J Emot Behav Disord
Y1 - 2006///Sum 2006
VL - 14
IS - 2
SP - 86
EP - 98
CY - US
PB - PRO-ED
SN - 1063-4266
SN - 1538-4799
AD - Wagner, Mary, SRI International, 333 Ravenswood Ave., Menlo Park, CA, US, 94025
N1 - Accession Number: 2006-08878-003. Partial author list: First Author & Affiliation: Wagner, Mary; Center for Education and Human Services, SRI International, Menlo Park, CA, US. Other Publishers: Sage Publications. Release Date: 20060731. Correction Date: 20111003. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Attention; Emotional Disturbances; Life Changes; Special Education; Students. Minor Descriptor: Family. Classification: Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Student's School Program Survey; General Education Teacher Survey; School Characteristics Survey. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Sum 2006.
AB - The authors describe five principles they identified from the literature on exemplary practices to help students with emotional disturbances (ED) have positive secondary school experiences and successful trajectories into early adulthood. The five are relationships, rigor, relevance, attention to the whole child, and involving students and families in goal-driven transition planning. The authors evaluated implementation of these practices for middle and secondary school students with ED by using data from a nationally representative longitudinal study of students receiving special education services. The results suggest that exposure to best practices has improved since the 1980s and is similar to that for students with other disabilities, but significant opportunity for improvement remains. The authors also identify implications for school programming. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - students
KW - emotional disturbances
KW - transition
KW - young adulthood
KW - special education
KW - families
KW - rigor
KW - relevnce
KW - attention
KW - 2006
KW - Attention
KW - Emotional Disturbances
KW - Life Changes
KW - Special Education
KW - Students
KW - Family
KW - 2006
U1 - Sponsor: US Department of Education, US. Recipients: No recipient indicated
U1 - Sponsor: Institute for Education Science, National Center for Special Education. Grant: ED-01-CO-0003. Other Details: NLTS2. Recipients: No recipient indicated
DO - 10.1177/10634266060140020501
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08878-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08374-004
AN - 2006-08374-004
AU - Kirby, James B.
AU - Kaneda, Toshiko
T1 - Access to Health Care: Does Neighborhood Residential Instability Matter?
JF - Journal of Health and Social Behavior
JO - Journal of Health and Social Behavior
JA - J Health Soc Behav
Y1 - 2006/06//
VL - 47
IS - 2
SP - 142
EP - 155
CY - US
PB - American Sociological Assn
SN - 0022-1465
SN - 2150-6000
AD - Kirby, James B., Agency for Healthcare Research and Quality, 540 Gaither Road, 5th floor, Rockville, MD, US, 20850
N1 - Accession Number: 2006-08374-004. PMID: 16821508 Other Journal Title: Journal of Health & Human Behavior. Partial author list: First Author & Affiliation: Kirby, James B.; Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20060731. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Income Level; Neighborhoods. Minor Descriptor: Community Attitudes; Health Insurance. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Jun, 2006.
AB - Many Americans do not have access to adequate medical care. Previous research on this problem focuses primarily on individual-level determinants of access such as income and insurance coverage. The role of community-level factors in helping or hindering individuals in obtaining needed medical care, however, has not received much attention. We address this gap in the literature by investigating the association between neighborhood residential instability and access to health care. Using individual-level data from the 2000 Medical Expenditure Panel Survey and block-group level data from the 2000 decennial census, we find that individuals who live in neighborhoods with high residential turnover have worse health care access than residents of other neighborhoods. This association persists even when the prevalence of poverty, the supply of health care, and a variety of individual characteristics are held constant. We offer explanations for these findings and suggest directions for future research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care
KW - neighborhood residential instability
KW - income
KW - insurance coverage
KW - community level factors
KW - 2006
KW - Health Care Services
KW - Income Level
KW - Neighborhoods
KW - Community Attitudes
KW - Health Insurance
KW - 2006
DO - 10.1177/002214650604700204
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08374-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07104-003
AN - 2006-07104-003
AU - Butler, Christopher C.
AU - Vidal-Alaball, Josep
AU - Cannings-John, Rebecca
AU - McCaddon, Andrew
AU - Hood, Kerenza
AU - Papaioannou, Alexandra
AU - Mcdowell, Ian
AU - Goringe, Andrew
T1 - Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency: A systematic review of randomized controlled trials.
JF - Family Practice
JO - Family Practice
JA - Fam Pract
Y1 - 2006/06//
VL - 23
IS - 3
SP - 279
EP - 285
CY - United Kingdom
PB - Oxford University Press
SN - 0263-2136
SN - 1460-2229
AD - Vidal-Alaball, Josep, National Public Health Service for Wales, 36 Orchard Street, Swansea, United Kingdom, SA1 5AQ
N1 - Accession Number: 2006-07104-003. PMID: 16585128 Partial author list: First Author & Affiliation: Butler, Christopher C.; Department of General Practice, Wales. Release Date: 20060605. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Administration Methods; Treatment Effectiveness Evaluation; Vitamin Deficiency Disorders; Vitamin Therapy; Vitamins. Minor Descriptor: Aging. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2006.
AB - Background. Vitamin B₁₂ deficiency is common, increasing with age. Most people are treated in primary care with intramuscular vitamin B₁₂. Several studies have reported equal efficacy of oral administration of vitamin B₁₂. Objectives. We set out to identify randomized controlled trial (RCT) evidence for the effectiveness of oral versus intramuscular vitamin B₁₂ to treat vitamin B₁₂ deficiency. Methods. We conducted a systematic review searching databases for relevant RCTs. Outcomes included levels of serum vitamin B₁₂ total serum homocysteine and methylmalonic acid, haemoglobin and signs and symptoms of vitamin B₁₂ deficiency. Results. Two RCTs comparing oral with intramuscular administration of vitamin B₁₂ met our inclusion criteria. The trials recruited a total of 108 participants and followed up 93 of these from 90 days to 4 months. In one of the studies, mean serum vitamin B₁₂ levels were significantly higher in the oral (643 ± 328 pg/ml; n = 18) compared with the intramuscular group (306 ±118 pg/ml; n = 15) at 2 months (P<0.001) and 4 months (1005 ± 595 versus 325 ± 165 pg/ml; P< 0.0005) and both groups had neurological responses. In the other study, serum vitamin B₁₂ levels increased significantly in those receiving oral vitamin B₁₂ and intramuscular vitamin B₁₂ (P< 0.001). Conclusions. The evidence derived from these limited studies suggests that 2000 μg doses of oral vitamin B₁₂ daily and 1000 μg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short-term haematological and neurological responses in vitamin B₁₂-deficient patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vitamin B
KW - vitamin deficiency
KW - aging
KW - randomized controlled trial
KW - treatment effectiveness
KW - oral administration
KW - intramuscular administration
KW - 2006
KW - Drug Administration Methods
KW - Treatment Effectiveness Evaluation
KW - Vitamin Deficiency Disorders
KW - Vitamin Therapy
KW - Vitamins
KW - Aging
KW - 2006
DO - 10.1093/fampra/cml008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07104-003&site=ehost-live&scope=site
UR - Josep.Vidal-Alaball@nphs.wales.nhs.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-06978-002
AN - 2006-06978-002
AU - Harris, Katherine M.
AU - Carpenter, Christopher
AU - Bao, Yuhua
T1 - The Effects of State Parity Laws on the Use of Mental Health Care.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2006/06//
VL - 44
IS - 6
SP - 499
EP - 505
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Harris, Katherine M., Rand Corporation, 1200 South Hayes Street, Arlington, VA, US, 22202
N1 - Accession Number: 2006-06978-002. PMID: 16707997 Partial author list: First Author & Affiliation: Harris, Katherine M.; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20061218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Insurance; Laws; Mental Health Services; Health Care Reform. Minor Descriptor: Distress. Classification: Health & Mental Health Services (3370); Civil Rights & Civil Law (4210). Population: Human (10); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: K6 Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2006.
AB - Objective: We used a quasiexperimental research design to measure the effect of state parity laws on the use of mental health care in the past year. Methods: We pooled cross-sectional data from the 2001, 2002, and 2003 National Surveys on Drug Use and Health. Our sample included 83,531 adults 18 years of age or over with private health insurance stratified by the level of mental and emotional distress experienced in the worst month of the past year. We used a state and year-fixed effects approach to measure the effect of parity. Similar to a difference-in-difference analysis, the effect of parity was measured by comparing pre-/postchanges in mental health service use within states that switched active parity status to changes in service use within states that did not change parity status in the same calendar year. For each subgroup, we report predictions of the percentage point change in any mental health care use, prescription drug use, and outpatient care use resulting from parity laws. Results: Depending on the time window used to define active parity status, we found that parity increased the probability of using any mental health care in the past year by as much as 1.2 percentage points (P < 0.01) for the lower distress group and by as much as 1.8 percentage points (P < 0.05) in the middle distress group. We found no statistically significant changes in service use for the upper distress group. Whether measured differences were attributable to changes in the use of prescription drug or outpatient care also depended on the definition of active parity status. Conclusions: Overall, the results of this study suggest that state parity laws succeeded in expanding access to mental health care for those with relatively mild mental health problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - mental health services
KW - health insurance
KW - state parity laws
KW - emotional distress
KW - mental distress
KW - 2006
KW - Health Insurance
KW - Laws
KW - Mental Health Services
KW - Health Care Reform
KW - Distress
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Recipients: No recipient indicated
DO - 10.1097/01.mlr.0000215813.16211.00
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-06978-002&site=ehost-live&scope=site
UR - kharris@rand.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07568-011
AN - 2006-07568-011
AU - Lyons-Warren, A.
AU - Chang, J. J.
AU - Balkissoon, R.
AU - Kamiya, A.
AU - Garant, M.
AU - Nurnberger, J.
AU - Scheftner, W.
AU - Reich, T.
AU - McMahon, F. J.
AU - Kelsoe, J.
AU - Gershon, E.
AU - Coryell, W.
AU - Byerley, W.
AU - Berrettini, W.
AU - DePaulo, R.
AU - Mclnnis, M.
AU - Sawa, A.
T1 - Evidence of association between bipolar disorder and Citron on chromosome 12q24.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2006/06//
VL - 11
IS - 6
SP - 612
EP - 612
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
N1 - Accession Number: 2006-07568-011. Partial author list: First Author & Affiliation: Lyons-Warren, A.; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20060619. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Erratum/Correction. Language: English. Major Descriptor: Bipolar Disorder; Chromosomes; Genes; Genetics; Polymorphism. Classification: Affective Disorders (3211). Population: Human (10). Page Count: 1. Issue Publication Date: Jun, 2006.
AB - Reports an error in the original article by A. Lyons-Warren (Molecular Psychiatry, 2005[Sep], Vol 10[9], 807-809). There is an algorithmic error. The correct data is given in the current article. (The following abstract of this article originally appeared in record [rid]2005-10937-003[/rid]). Presents a letter to the editor discussing evidence of association between bipolar disorder and Citron on chromosome 12q24. This study tested for association in the National Institutes of Mental Health (NIMH) Genetics Initiative wave 3 and wave 4 pedigrees. The sample set available consisted of 307 nuclear families consisting of 1012 individuals, including probands diagnosed with BPI, BPII, (Bipolar disorder) schizoaffective disorder, or unipolar depression. Seven common single nucleotide polymorphisms (SNPs) were chosen roughly equidistant across the 195kb Citron gene. Individuals with unlikely recombination events and families with Mendelian errors were excluded from the analysis. Marker-to-marker linkage disequilibrium (LD) and Hardy-Weinberg equilibrium were determined using Haploview. Pedigrees were analyzed for the presence of association using the Family-Based Association Test (FBAT), a version of a transmission disequilibrium. This study provides the first evidence of a candidate gene for BP on chromosome 12q24, a linkage locus for BP common to many studies. The evidence suggests a possible association of the Citron gene and BP in a family-based sample set. Of particular interest are two SNPs (rs203368 and rs435136) in the proximity of exons that code for the DISC1 binding domain on Citron. The studies warrant further study of Citron and adjacent genes in larger samples and in other ethnic groups in the investigation of a possible etiology for major mood disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bipolar disorder
KW - Citron gene
KW - polymorphisms
KW - chromosomes
KW - 2006
KW - Bipolar Disorder
KW - Chromosomes
KW - Genes
KW - Genetics
KW - Polymorphism
KW - 2006
DO - 10.1038/sj.mp.4001842
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07568-011&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-07103-014
AN - 2006-07103-014
AU - Burke-Miller, Jane K.
AU - Cook, Judith A.
AU - Cohen, Mardge H.
AU - Hessol, Nancy A.
AU - Wilson, Tracey E.
AU - Richardson, Jean L.
AU - Williams, Pete
AU - Gange, Stephen J.
T1 - Longitudinal Relationships Between Use of Highly Active Antiretroviral Therapy and Satisfaction With Care Among Women Living with HIV/AIDS.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/06//
VL - 96
IS - 6
SP - 1044
EP - 1051
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Burke-Miller, Jane K., Center on Mental Health Services Research and Policy, University of Illinois at Chicago, 104 S Michigan Ave, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2006-07103-014. PMID: 16670232 Partial author list: First Author & Affiliation: Burke-Miller, Jane K.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20061226. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Satisfaction; Drug Therapy; Health; HIV; Quality of Life. Classification: Immunological Disorders (3291); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Medical Outcomes Study HIV Instrument; RAND Patient Satisfaction Questionaire, Short Form; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2006.
AB - Objectives: We used longitudinal data to examine the roles of 4 dimensions of patient satisfaction as both predictors and outcomes of use of highly active antiretroviral therapy (HAART) among women in the United States with HIV/AIDS. Methods: Generalized estimating equations were used to analyze time-lagged satisfaction-HAART relationships over 8 years in the Women's Interagency HIV Study. Results: Multivariate models showed that, over time, HAART use was associated with higher patient satisfaction with care in general, with providers, and with access/convenience of care; however, patient satisfaction was not associated with subsequent HAART use. Symptoms of depression and poor health-related quality of life were associated with less satisfaction with care on all 4 dimensions assessed, whereas African American race/ethnicity, illegal drug use, and fewer primary care visits were associated with less HAART use. Conclusions: Our findings suggest that dissatisfaction with care is not a reason for underuse of HAART among women with HIV and that providers should not be discouraged from recommending HAART to dissatisfied patients. Rather, increasing women's access to primary care could result in both increased HAART use and greater patient satisfaction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - longitudinal relationships
KW - highly active antiretroviral therapy
KW - women
KW - HIV
KW - AIDS
KW - patient satisfaction
KW - 2006
KW - Client Satisfaction
KW - Drug Therapy
KW - Health
KW - HIV
KW - Quality of Life
KW - 2006
U1 - Sponsor: National Institute of Allergy and Infectious Diseases, US. Other Details: Women's Interagency HIV. Recipients: No recipient indicated
U1 - Sponsor: National Cancer Institute, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: UO1-AI-35004; UO1-AI-31834; UO1-AI-34994; UO1-AI-34989; UO1-AI-34993; UO1-AI-42590. Recipients: No recipient indicated
U1 - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Grant: UO1-CH-32632. Recipients: No recipient indicated
U1 - Sponsor: National Center for Research Resources, US. Grant: MO1-RR-00071; MO1-RR-00079; MO1-RR-00083. Recipients: No recipient indicated
DO - 10.2105/AJPH.2005.061929
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-07103-014&site=ehost-live&scope=site
UR - ORCID: 0000-0001-7842-512X
UR -
UR - jburke@psych.uic.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106136302
T1 - Efficacy evaluation of current and future platelet transfusion products.
AU - Vostal JG
Y1 - 2006/06/02/2006 Supplement
N1 - Accession Number: 106136302. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2006 Supplement. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376373.
KW - Blood Platelets -- Physiology
KW - Blood Preservation
KW - Platelet Transfusion
KW - Plateletpheresis
SP - S78
EP - 82
JO - Journal of Trauma
JF - Journal of Trauma
JA - J TRAUMA
VL - 60
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0022-5282
AD - Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852-1448, USA. vostal@cber.fda.gov
U2 - PMID: 16763485.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106136302&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, Jeffrey S.
AU - Jie Tian
AU - Stevenson, Susan C.
AU - Byrnes, Andrew P.
T1 - 381. The Adenoviral Fiber Shaft Is a Major Determinant of Kupffer Cell Necrosis.
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2006/06/02/
VL - 13
M3 - Article
SP - S145
EP - S145
SN - 15250016
AB - When adenoviral vectors are administered systemically, they are quickly taken up by phagocytes of the reticuloendothelial system, including Kupffer cells (KCs) in the liver. We have recently shown in mice that E1/E3-deleted Ad5 vectors cause rapid KC death, followed by a slower depletion of KCs from the liver (Mol. Ther. 13:108-117, 2006). KCs lost membrane integrity within 10 min after i.v. injection of Ad5 vectors, and this eventually resulted in significant depletion of KCs from the liver. In the current study, we investigated which features of the adenoviral fiber contribute to KC toxicity by administering Ad5 vectors with the fiber partially or completely replaced by the type 35 fiber. When compared to the type 5 fiber, the type 35 fiber does not bind to CAR, has a much shorter shaft, and lacks a putative heparin-binding domain (KKTK) in the shaft. We also directly examined the role of the KKTK domain in the Ad5 shaft. All vectors were provided by Cell Genesys, Inc. and were described in Hum. Gene Ther. 14:777-787, 2003.C57Bl/6 mice were injected i.v. with vectors and F4/80+ KCs in the liver were counted at 18 h. An Ad5 vector dose of 1011 vp/kg depleted KCs by approximately 80%. KCs were depleted to a similar extent when the type 5 fiber head was replaced with the type 35 fiber head (5S35H), indicating that the type 5 and type 35 fiber heads were interchangeable and that CAR binding was not essential. However, when the type 5 shaft was replaced with the type 35 shaft, no KC depletion was seen, regardless of whether the fiber was completely replaced (35F) or only the shaft was replaced (35S5H). In addition, KC depletion was also absent with an Ad5 vector that had the shaft KKTK sequence replaced with GAGA (S*). This indicated that the shaft length did not determine toxicity, but rather that the putative heparin-binding domain was involved. Of note, all of the vectors were capable of producing KC depletion to some degree when injected at higher doses (1012 vp/kg), indicating that none of the alterations provided absolute protection against KC toxicity.In summary, we found that the type 5 fiber shaft made a major contribution to KC toxicity. Vectors that lacked the KKTK motif or contained the type 35 fiber shaft were impaired in their ability to deplete KCs. There was no obvious contribution from the type 5 fiber head, and CAR binding played no apparent role in KC toxicity. This information is likely to prove valuable in developing less toxic adenoviral vectors for systemic administration.Molecular Therapy (2006) 13, S145–S145; doi: 10.1016/j.ymthe.2006.08.441 [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KUPFFER cells
KW - NECROSIS
KW - POLYSACCHARIDES
KW - LIVER cells
KW - IMMUNE system
KW - HEPARIN
N1 - Accession Number: 25974131; Smith, Jeffrey S. 1 Jie Tian 1 Stevenson, Susan C. 2 Byrnes, Andrew P. 1; Affiliation: 1: Division of Cell and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, MD. 2: Department of Diabetes and Metabolism, Novartis Institutes of Biomedical Research Inc., Cambridge, MA.; Source Info: Jun2006, Vol. 13, pS145; Subject Term: KUPFFER cells; Subject Term: NECROSIS; Subject Term: POLYSACCHARIDES; Subject Term: LIVER cells; Subject Term: IMMUNE system; Subject Term: HEPARIN; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ymthe.2006.08.441
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25974131&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kwang-soo Ahn
AU - Seok Kee Chang
AU - Dokeun Kim
AU - Won Shin
AU - Yeowon Sohn
T1 - 600. Transduced Cells with Lentiviral Vector Expressing gp41-Derived c-Peptide Are Protected from HIV-1 Infection.
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2006/06/02/
VL - 13
M3 - Article
SP - S232
EP - S232
SN - 15250016
AB - The HIV-1 envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41. Upon activation of the envelope glycoprotein by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes. The gp41 C-terminal heptad repeat region interacts with the N-terminal coiled-coil region to form a six-stranded core structure. As the limitations of anti-retroviral drug therapy, such as toxicity and resistance, interest in alternative therapeutic approaches for HIV-1 infection is growing. Based on HIV-1 glycoprotein, peptides derived from gp41 C-terminal heptad repeat region (C- peptides) are potent HIV-1 entry inhibitors by binding to gp41 N- terminal coiled-coil region. We hypothesize that expression of a membrane-bound C-peptides will confer HIV-1 resistance to target cells. Efficient gene delivery and stable expression of a membrane- bound C-peptides to target cells was accomplished using a self- inactivating lentiviral vector. Also, to achieve maximal expression and antiviral activity, the scaffold for presentation of the peptide on the cell surface was optimized. The HIV-1 entry inhibition effect by membrane-bound C-peptides can be mimicked by a fusion process between cells expressing the HIV envelope glycoprotein (gp160) and cells expressing both C-peptides together with human CD4 receptors. In this report, fusion events were monitored by the luciferase reporter system.In addition to these experiments, we designed viruses which have HIV-1 envelope glycoprotein and express green fluorescence protein (GFP), and a potent antiviral effect was observed when C-peptides expressed cells were challenged with these virus. In this study, We have found that expression of membrand bound C-peptides inhibited membrane fusion and virus infectivity as well as cytopathic effects were absent in transduced cells. Results from this study support the rationale to use this lentiviral vector targeted at HIV entry as a potential gene therapy for HIV infection.Molecular Therapy (2006) 13, S232–S232; doi: 10.1016/j.ymthe.2006.08.674 [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - C-peptide
KW - DRUG therapy
KW - GENETIC engineering
KW - GENE therapy
N1 - Accession Number: 25973912; Kwang-soo Ahn 1 Seok Kee Chang 1 Dokeun Kim 1 Won Shin 1 Yeowon Sohn 1; Affiliation: 1: Biologics Headquarters, Korea Food and Drug Administration, Seoul, Korea.; Source Info: Jun2006, Vol. 13, pS232; Subject Term: HIV infections; Subject Term: C-peptide; Subject Term: DRUG therapy; Subject Term: GENETIC engineering; Subject Term: GENE therapy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ymthe.2006.08.674
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25973912&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wicker, Jason A.
AU - Whiteman, Melissa C.
AU - Beasley, David W.C.
AU - Davis, C. Todd
AU - Zhang, Shuliu
AU - Schneider, Bradley S.
AU - Higgs, Stephen
AU - Kinney, Richard M.
AU - Barrett, Alan D.T.
T1 - A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice
JO - Virology
JF - Virology
Y1 - 2006/06/05/
VL - 349
IS - 2
M3 - Article
SP - 245
EP - 253
SN - 00426822
AB - Abstract: West Nile virus (WNV) NS4B is a small hydrophobic nonstructural protein that is hypothesized to participate both in viral replication and evasion of host innate immune defenses. The protein has four cysteine residues (residues 102, 120, 227, and 237). Since cysteines are often critical for the function of proteins, each of the four cysteine residues found in WNV NS4B was mutated to serine by site-directed mutagenesis. While three of these substitutions had little effect on replication or mouse virulence phenotypes, the C102S mutation was associated with a temperature-sensitive phenotype at 41 °C as well as attenuation of the neuroinvasive and neurovirulence phenotypes in mice. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL replication
KW - GENOTYPE-environment interaction
KW - AMINO acids
KW - PROTEINS
KW - Attenuated phenotype
KW - Cysteine
KW - Flavivirus
KW - NS4B protein
KW - West Nile virus
N1 - Accession Number: 20980898; Wicker, Jason A. 1 Whiteman, Melissa C. 2 Beasley, David W.C. 1,2 Davis, C. Todd 2 Zhang, Shuliu 2 Schneider, Bradley S. 2 Higgs, Stephen 2 Kinney, Richard M. 3 Barrett, Alan D.T. 1,2; Email Address: abarrett@utmb.edu; Affiliation: 1: Department of Microbiology and Immunology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, TX 77555-0609, USA 2: Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch at Galveston, TX 77555-0609, USA 3: Division of Vector-Borne Viral Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA; Source Info: Jun2006, Vol. 349 Issue 2, p245; Subject Term: VIRAL replication; Subject Term: GENOTYPE-environment interaction; Subject Term: AMINO acids; Subject Term: PROTEINS; Author-Supplied Keyword: Attenuated phenotype; Author-Supplied Keyword: Cysteine; Author-Supplied Keyword: Flavivirus; Author-Supplied Keyword: NS4B protein; Author-Supplied Keyword: West Nile virus; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2006.03.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20980898&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nazzal, Sami
AU - Khan, Mansoor A.
T1 - Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2006/06/06/
VL - 315
IS - 1/2
M3 - Article
SP - 110
EP - 121
SN - 03785173
AB - Abstract: The objective of this study was to evaluate the effect of some processing parameters on the release of lipid formulation from a tablet dosage form. A 17-run, face-centered cubic design was employed to evaluate the effect of colloidal silicates (X 1), magnesium stearate mixing time (X 2), and compression force (X 3) on flow, hardness, and dissolution of Coenzyme Q10 (CoQ10) lipid formulation from a tablet dosage form. The optimized formulation was subsequently subjected to a short-term accelerated stability study. All preparations had a flowability index values ranging from 77 to 90. The cumulative percent of CoQ10 released within 8h (Y 5) ranged from 40.6% to 90% and was expressed by the following polynomial equation: . When stored at 4°C, dissolution rates were retained for up to 3 months. Storage at higher temperatures, however, accelerated lipid release and caused leakage, and loss of hardness. Processing parameters have a profound effect on the release of lipid formulations from their solid carriers. While optimized controlled release formulations could be attained, further considerations should be made to prepare “liquisolids” that are physically stable at higher storage temperatures. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UBIQUINONES
KW - DRUG delivery systems
KW - PHARMACEUTICAL technology
KW - COENZYMES
KW - Coenzyme Q10
KW - Controlled release
KW - Face-centered cubic design
KW - Optimization
KW - Self-emulsified drug delivery system
KW - Stability
N1 - Accession Number: 20821894; Nazzal, Sami 1; Email Address: nazzal@ulm.edu Khan, Mansoor A. 2; Affiliation: 1: Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA 2: Division of Product Quality Research, Food and Drug Administration, Federal Research Center, Silver Spring, MD, USA; Source Info: Jun2006, Vol. 315 Issue 1/2, p110; Subject Term: UBIQUINONES; Subject Term: DRUG delivery systems; Subject Term: PHARMACEUTICAL technology; Subject Term: COENZYMES; Author-Supplied Keyword: Coenzyme Q10; Author-Supplied Keyword: Controlled release; Author-Supplied Keyword: Face-centered cubic design; Author-Supplied Keyword: Optimization; Author-Supplied Keyword: Self-emulsified drug delivery system; Author-Supplied Keyword: Stability; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ijpharm.2006.02.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20821894&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marsh, S. M.
AU - Derk, S. J.
AU - Jackson, L. L.
T1 - Nonfatal Occupational Injuries and Illnesses Among Workers Treated in Hospital Emergency Departments--United States, 2003.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/06/07/
VL - 295
IS - 21
M3 - Article
SP - 2470
EP - 2472
SN - 00987484
AB - The article reports information from the Centers for Disease Control on nonfatal occupational injuries among workers treated in emergency departments in the United States for 2003. Injury rate and nature did not change since 1998, indicating that directed interventions must be made to make a significant increase in workplace safety. Data comes from the Institute for Occupational Safety and Health's National Electronic Injury Surveillance System. Data includes information on occupation, the nature of the injury or illness, and the age and gender of the patient.
KW - WORK environment
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - HOSPITAL emergency services
KW - OCCUPATIONAL hazards
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 21064928; Marsh, S. M. Derk, S. J. Jackson, L. L. 1; Affiliation: 1: Div. of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control; Source Info: 6/7/2006, Vol. 295 Issue 21, p2470; Subject Term: WORK environment; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: HOSPITAL emergency services; Subject Term: OCCUPATIONAL hazards; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21064928&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kang, Yun Hee
AU - Lee, Kyung-Ae
AU - Ryu, Chun Jeih
AU - Lee, Hee-Gu
AU - Lim, Jong-Seok
AU - Park, Sue Nie
AU - Paik, Sang-Gi
AU - Yoon, Do-Young
T1 - Mitomycin C induces apoptosis via Fas/FasL dependent pathway and suppression of IL-18 in cervical carcinoma cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2006/06/08/
VL - 237
IS - 1
M3 - Article
SP - 33
EP - 44
SN - 03043835
AB - Abstract: Mitomycin C (MMC) is used fairly widely as an anticancer drug, as it possesses mechanisms of action which are preferable to other chemotherapeutic compounds, including cisplatin, docetaxel, and lovastatin. In the previous study, we established the RSV-luc promoter analysis system, which is used to screen drugs against cervical carcinomas caused by HPV infection. We then demonstrated the repression of HPV E6-activated RSV promoter activity by anticancer agents such as carboplatin (CA), cisplatin (CIS), and MMC. In these studies, we focused on the investigation of apoptotic mechanisms in MMC-treated cervical carcinoma cell lines, most notably SiHa/pRSV-luc (KCTC 0427BP) and SiHa. DNA fragmentation assays and TUNEL staining revealed that MMC and CIS, but not CA, resulted in apoptosis. MMC treatment induced a reduction in the expressions of the E6 oncogene and IL-18, in a p53-independent manner. MMC also increased FasL expression and induced the processing of caspases-8 and -3. Our results indicated that MMC induced apoptosis in SiHa/pRSV-luc and SiHa cells via caspase-8 and -3 processing, in a Fas/FasL-dependent manner. MMC also suppressed the expression of IL-18 in the same cells. MMC also down-regulated IκB expression, and up-regulated p65 expression. These results suggest that MMC induces apoptosis, not only through caspase-8 and -3 dependent Fas/FasL pathway, but also via the regulation of NF-κB activity and IL-18 expression. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CELL death
KW - IMMUNOSUPPRESSIVE agents
KW - MITOMYCIN C
KW - Apoptosis
KW - Caspase-8
KW - Cervical carcinoma cells
KW - FasL
KW - Interleukin-18
KW - Mitomycin C
N1 - Accession Number: 20874872; Kang, Yun Hee 1,2 Lee, Kyung-Ae 1 Ryu, Chun Jeih 1 Lee, Hee-Gu 1 Lim, Jong-Seok 1 Park, Sue Nie 3 Paik, Sang-Gi 2 Yoon, Do-Young 1; Email Address: dyyoon@kribb.re.kr; Affiliation: 1: Division of Cellomics, Laboratory of Cell Biology, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Daejeon 305-600, South Korea 2: Department of Biology, Chungnam National University, Daejeon 305-764, South Korea 3: Division of Blood Products, Korea Food and Drug Administration, Seoul 122-701, South Korea; Source Info: Jun2006, Vol. 237 Issue 1, p33; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: MITOMYCIN C; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Caspase-8; Author-Supplied Keyword: Cervical carcinoma cells; Author-Supplied Keyword: FasL; Author-Supplied Keyword: Interleukin-18; Author-Supplied Keyword: Mitomycin C; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.canlet.2005.05.043
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Borrow, R.
AU - Carlone, G.M.
AU - Rosenstein, N.
AU - Blake, M.
AU - Feavers, I.
AU - Martin, D.
AU - Zollinger, W.
AU - Robbins, J.
AU - Aaberge, I.
AU - Granoff, D.M.
AU - Miller, E.
AU - Plikaytis, B.
AU - van Alphen, L
AU - Poolman, J.
AU - Rappuoli, R.
AU - Danzig, L.
AU - Hackell, J.
AU - Danve, B.
AU - Caulfield, M.
AU - S, Lambert
T1 - Neisseria meningitidis group B correlates of protection and assay standardization—International Meeting Report Emory University, Atlanta, Georgia, United States, 16–17 March 2005
JO - Vaccine
JF - Vaccine
Y1 - 2006/06/12/
VL - 24
IS - 24
M3 - Proceeding
SP - 5093
EP - 5107
SN - 0264410X
N1 - Accession Number: 21266944; Borrow, R. 1; Email Address: ray.borrow@hpa.org.uk; Carlone, G.M. 2; Rosenstein, N. 2; Blake, M. 3; Feavers, I. 4; Martin, D. 5; Zollinger, W. 6; Robbins, J. 7; Aaberge, I. 8; Granoff, D.M. 9; Miller, E. 10; Plikaytis, B. 2; van Alphen, L 11; Poolman, J. 12; Rappuoli, R. 13; Danzig, L. 14; Hackell, J. 15; Danve, B. 16; Caulfield, M. 17; S, Lambert 18; Affiliations: 1: Vaccine Evaluation Unit, Health Protection Agency, Manchester Royal Infirmary, Manchester M13 9WZ, United Kingdom; 2: Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Food and Drug Administration, Bethesda, MD, USA; 4: National Institute for Biological Standards and Control, Potters Bar, United Kingdom; 5: Institute of Environmental Science, Porirua, New Zealand; 6: Walter Reed Army Institute of Research, Washington, DC, USA; 7: National Institute of Child Health and Human Development, National Institute for Health, Bethesda, MD 20892, USA; 8: Norwegian Institute of Public Health, NO-0403 Oslo, Norway; 9: Children's Hospital Oakland Research Institute, Oakland, CA 946609, USA; 10: Health Protection Agency Centre for Infections, Colindale, London NW9 5EQ, United Kingdom; 11: Netherlands Vaccine Institute, NL-3720 AL Bilthoven, The Netherlands; 12: GlaxoSmithKline Biologicals, Rixensart, Belgium; 13: Chiron Vaccines, Siena, Italy; 14: Chiron Vaccines, Emeryville, CA 94608, USA; 15: Wyeth Vaccines, Pearl River, NY 10965, USA; 16: Sanofi Pasteur, F69280 Marcy l’Etoile, France; 17: Merck & Co., Inc, West Point, PA 19486, USA; 18: World Health Organization, CH-1211 Geneva 27, Switzerland; Issue Info: Jun2006, Vol. 24 Issue 24, p5093; Number of Pages: 15p; Document Type: Proceeding
L3 - 10.1016/j.vaccine.2006.03.091
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pei Zhang
AU - Yu, Mei-ying W.
AU - Venable, Richard
AU - Alter, Harvey J.
AU - Wai-Kou Shih, J.
T1 - Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2006/06/13/
VL - 103
IS - 24
M3 - Article
SP - 9214
EP - 9219
SN - 00278424
AB - Neutralizing monoclonal antibody (BX-182) directed against the d determinant of hepatitis B virus (HBV) surface antigen protected chimpanzees from infection by HBV subtype adw but not by subtype ayw, as demonstrated by intravenously inoculating a mixture of the antibody with the respective subtype of the virus. To elucidate the mechanism underlying the subtype-specific protection, a combinatorial approach of screening random peptide phage libraries, bioinformatics, and structure analysis was used in this study to identify the neutralization epitope responsible for the observed protection. The epitope was mapped at the N terminus of the pre-S1 region of the hepatitis B surface antigen between residues 17 and 21, of which the residues Val-18/Pro-19 were critical for antibody binding. Alignment of amino acid sequences derived from diverse genetic variants of HBV revealed that the epitope was present in ad subtypes and in their corresponding genotypes A, B, C, F, and H. By contrast, this epitope was not found in a majority of ay subtypes or in genotypes D, E, and G, where the antigenic residues Val-18/Pro-19 within the epitope were replaced by Thr/Ser, Thr/Thr, or Ala/Ser, respectively, resulting in a drastic conformational change of the epitope. These data indicate that, by binding discriminately to the subtype ‘d’ epitope in the pre-S1 region, neutralizing antibody BX-182 protects chimpanzees from HBV infection in a subtype-specific manner, suggesting a potential escape mechanism for HBV genetic variants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - HEPATITIS B virus
KW - CELL surface antigens
KW - CHIMPANZEES
KW - GENETIC polymorphisms
KW - MOLECULAR cloning
KW - hepatitis B surface antigen
KW - neutralizing antibody
N1 - Accession Number: 21403004; Pei Zhang 1; Email Address: pei.zhang@fda.hhs.gov Yu, Mei-ying W. 1 Venable, Richard 2 Alter, Harvey J. 3; Email Address: halter@mail.nih.gov Wai-Kou Shih, J. 3; Email Address: jshih@cc.nih.gov; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 2: Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 3: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892; Source Info: 6/13/2006, Vol. 103 Issue 24, p9214; Subject Term: MONOCLONAL antibodies; Subject Term: HEPATITIS B virus; Subject Term: CELL surface antigens; Subject Term: CHIMPANZEES; Subject Term: GENETIC polymorphisms; Subject Term: MOLECULAR cloning; Author-Supplied Keyword: hepatitis B surface antigen; Author-Supplied Keyword: neutralizing antibody; Number of Pages: 6p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1073/pnas.0603316103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jingsheng Tuo
AU - Baitang Ning
AU - Bojanowski, Christine M.
AU - Zhong-Ning Lin
AU - Ross, Robert J.
AU - Reed, George F.
AU - Shen, Defen
AU - Xiaodong Jiao
AU - Min Zhou
AU - Chew, Emily Y.
AU - Kadlubar, Fred F.
AU - Chi-Chao Chan
T1 - Synergic effect of polymorphisms in ERCC6 5′ flanking region and complement factor H on age-related macular degeneration predisposition.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2006/06/13/
VL - 103
IS - 24
M3 - Article
SP - 9256
EP - 9261
SN - 00278424
AB - This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP) and its disease association. We chose ERCC6 because of its roles in the aging process, DNA repair, and ocular degeneration from the gene disruption. Bioinformatics indicated a putative binding-element alteration on the sequence containing C-6530>G SNP in the 5′ flanking region of ERCC6 from Spl on the C allele to SP1, GATA-1, and OCT-1 on the G allele. Electrophoretic mobility shift assays displayed distinctive C and G allele-binding patterns to nuclear proteins. Luciferase expression was higher in the vector construct containing the G allele than that containing the C allele. A cohort of 460 advanced AMD cases and 269 age-matched controls was examined along with pathologically diagnosed 57 AMD and 18 age-matched non-AMD archived cases. ERCC6 C-6530>G was associated with AMD susceptibility, both independently and through interaction with an SNP (rs380390) in the complement factor H (CFH) intron reported to be highly associated with AMD. A disease odds ratio of 23 was conferred by homozygozity for risk alleles at both ERCC6 and CFH compared with homozygozity for nonrisk alleles. Enhanced ERCC6 expression was observed in lymphocytes from healthy donors bearing ERCC6 C-6530>G alleles. Intense immunostaining of ERCC6 was also found in AMD eyes from ERCC6 C-6530>G carriers. The strong AMD predisposition conferred by the ERCC6 and CFH SNPs may result from biological epistasis, because ERCC6 functions in universal transcription as a component of RNA pol I transcription complex. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETINAL degeneration
KW - NUCLEIC acids
KW - GENETIC polymorphisms
KW - GENETIC transformation
KW - DNA repair
KW - DEGENERATION (Pathology)
KW - Cockayne syndrome
KW - gene regulation
KW - interaction
KW - single nucleotide polymorphism
N1 - Accession Number: 21403011; Jingsheng Tuo 1 Baitang Ning 2 Bojanowski, Christine M. 1 Zhong-Ning Lin 2 Ross, Robert J. 1 Reed, George F. 3 Shen, Defen 1 Xiaodong Jiao 4 Min Zhou 1 Chew, Emily Y. 3 Kadlubar, Fred F. 2 Chi-Chao Chan 1; Email Address: chanc@nei.nih.gov; Affiliation: 1: Laboratory of Immunology, Section on Immunopathology, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2: Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079 3: Division of Epidemiology and Clinical Research, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4: Ophthalmic Genetics and Visual Function Branch, Section on Ophthalmic Molecular Genetics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892; Source Info: 6/13/2006, Vol. 103 Issue 24, p9256; Subject Term: RETINAL degeneration; Subject Term: NUCLEIC acids; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC transformation; Subject Term: DNA repair; Subject Term: DEGENERATION (Pathology); Author-Supplied Keyword: Cockayne syndrome; Author-Supplied Keyword: gene regulation; Author-Supplied Keyword: interaction; Author-Supplied Keyword: single nucleotide polymorphism; Number of Pages: 6p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1073/pnas.0603485103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Proudfoot, S.
AU - Hales, T.
AU - Struttmann, T. W.
AU - Guglielmo, C.
AU - Ridenour, M. L.
AU - Noe, R. S.
T1 - Fatalities Among Volunteer and Career Firefighters--United States, 1994-2004.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/06/14/
VL - 295
IS - 22
M3 - Article
SP - 2594
EP - 2596
SN - 00987484
AB - The article discusses the CDC study, "Fatalities Among Volunteer and Career Firefighters--United States, 1994-2004." The data is from the U.S. Fire Administration and the two cases were investigated by the National Institute for Occupational Safety and Health. Case 1 focuses on volunteer fatality. Case 2 focuses on career fatality. The CDC editorial note comments on the causes of firefighter deaths and limitations in this research, and offers recommendations to reduce the risk of cardiovascular disease among firefighters.
KW - FIRE fighters
KW - DEATH -- Causes
KW - INDUSTRIAL hygiene -- Research
KW - INDUSTRIAL safety
KW - RESEARCH
KW - CARDIOVASCULAR diseases
KW - MORTALITY
KW - GOVERNMENT agencies
KW - UNITED States
N1 - Accession Number: 21124718; Proudfoot, S. 1 Hales, T. 1 Struttmann, T. W. 1 Guglielmo, C. 1 Ridenour, M. L. 2 Noe, R. S. 2; Affiliation: 1: Div. of Safety Research, National Institute for Occupational Safety and Health 2: EIS officer, CDC; Source Info: 6/14/2006, Vol. 295 Issue 22, p2594; Subject Term: FIRE fighters; Subject Term: DEATH -- Causes; Subject Term: INDUSTRIAL hygiene -- Research; Subject Term: INDUSTRIAL safety; Subject Term: RESEARCH; Subject Term: CARDIOVASCULAR diseases; Subject Term: MORTALITY; Subject Term: GOVERNMENT agencies; Subject Term: UNITED States; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106133015
T1 - Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study.
AU - Hoppin JA
AU - Umbach DM
AU - London SJ
AU - Lynch CF
AU - Alavanja MCR
AU - Sandler DP
Y1 - 2006/06/15/
N1 - Accession Number: 106133015. Language: English. Entry Date: 20070810. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Intramural research funds from the National Cancer Institute and the National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services. NLM UID: 7910653.
KW - Herbicides -- Adverse Effects
KW - Heterocyclic Compounds -- Adverse Effects
KW - Occupational Exposure -- Adverse Effects
KW - Organic Chemicals -- Adverse Effects
KW - Pesticides -- Adverse Effects
KW - Respiratory Sounds
KW - Sulfonylurea Compounds -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Dose-Response Relationship, Drug
KW - Female
KW - Funding Source
KW - Iowa
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - Pearson's Correlation Coefficient
KW - Questionnaires
KW - Risk Factors
KW - Human
SP - 1129
EP - 1137
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 163
IS - 12
PB - Oxford University Press / USA
AB - Pesticides are potential risk factors for respiratory disease among farmers, but farmers are also exposed to other respiratory toxicants. To explore the association of pesticides with wheeze in a population without other farming exposures, the authors analyzed data from 2,255 Iowa commercial pesticide applicators enrolled in the Agricultural Health Study. Controlling for age, smoking status, asthma and atopy history, and body mass index, the authors calculated odds ratios for the relationship between wheeze and 36 individual pesticides participants had used during the year before enrollment (1993-1997). Eight of 16 herbicides were associated with wheeze in single-agent models; however, the risk was almost exclusively associated with the herbicide chlorimuron-ethyl (odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.25, 2.10). Inclusion of chlorimuron-ethyl in models for the other herbicides virtually eliminated the associations. The odds ratios for four organophosphate insecticides (terbufos, fonofos, chlorpyrifos, and phorate) were elevated when these chemicals were modeled individually and remained elevated, though attenuated somewhat, when chlorimuron-ethyl was included. The association for dichlorvos, another organophosphate insecticide, was not attenuated by chlorimuron-ethyl (OR = 2.48, 95% CI: 1.08, 5.66). Dose-response trends were observed for chlorimuron-ethyl, chlorpyrifos, and phorate; the strongest odds ratio was for applying chlorpyrifos on more than 40 days per year (OR = 2.40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl.
SN - 0002-9262
AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709-2233, USA. hoppin1@niehs.nih.gov
U2 - PMID: 16611668.
DO - aje/kwj138
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Drum, Bruce
T1 - Federal regulation of vision enhancement devices for normal and abnormal vision.
JO - Journal of Modern Optics
JF - Journal of Modern Optics
Y1 - 2006/06/15/
VL - 53
IS - 9
M3 - Article
SP - 1215
EP - 1228
SN - 09500340
AB - The Food and Drug Administration (FDA) evaluates the safety and effectiveness of medical devices and biological products as well as food and drugs. The FDA defines a device as a product that is intended, by physical means, to diagnose, treat, or prevent disease, or to affect the structure or function of the body. All vision enhancement devices fulfill this definition because they are intended to affect a function (vision) of the body. In practice, however, FDA historically has drawn a distinction between devices that are intended to enhance low vision as opposed to normal vision. Most low vision aids are therapeutic devices intended to compensate for visual impairment, and are actively regulated according to their level of risk to the patient. The risk level is usually low (e.g. Class I, exempt from 510(k) submission requirements for magnifiers that do not touch the eye), but can be as high as Class III (requiring a clinical trial and Premarket Approval (PMA) application) for certain implanted and prosthetic devices (e.g. intraocular telescopes and prosthetic retinal implants). In contrast, the FDA usually does not actively enforce its regulations for devices that are intended to enhance normal vision, are low risk, and do not have a medical intended use. However, if an implanted or prosthetic device were developed for enhancing normal vision, the FDA would likely decide to regulate it actively, because its intended use would entail a substantial medical risk to the user. Companies developing such devices should contact the FDA at an early stage to clarify their regulatory status. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Modern Optics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - VISION
KW - VISION disorders
KW - ARTIFICIAL implants
KW - BIOMEDICAL materials
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 21008053; Drum, Bruce 1; Email Address: bruce.drum@fda.hhs.gov; Affiliation: 1: Division of Ophthalmic and Ear, Nose and Throat Devices, Food and Drug Administration, 9200 Corporate Boulevard, Rockville, MD 20850, USA; Source Info: 6/15/2006, Vol. 53 Issue 9, p1215; Subject Term: MEDICAL equipment; Subject Term: VISION; Subject Term: VISION disorders; Subject Term: ARTIFICIAL implants; Subject Term: BIOMEDICAL materials; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 14p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/09500340600618363
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nishigaki, Kazuo
AU - Hanson, Charlotte
AU - Ohashi, Takashi
AU - Spadaccini, Angelo
AU - Ruscetti, Sandra
T1 - Erythroblast Transformation by the Friend Spleen Focus-Forming Virus Is Associated with a Block in Erythropoietin-Induced STAT1 Phosphorylation and DNA Binding and Correlates with High Expression of the Hematopoietic Phosphatase SHP-1.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/06/15/
VL - 80
IS - 12
M3 - Article
SP - 16
EP - 16
SN - 0022538X
AB - Infection of mice with Friend spleen focus-forming virus (SFFV) results in a multistage erythroleukemia. In the first stage, the SFFV envelope glycoprotein interacts with the erythropoietin receptor and a short form of the receptor tyrosine kinase sf-Stk, resulting in constitutive activation of signal transducing molecules and the development of erythropoietin (Epo)-independent erythroid hyperplasia and polycythemia. The second stage results from the outgrowth of a rare virus-infected erythroid cell that expresses nonphysiological levels of the myeloid transcription factor PU.1. These cells exhibit a differentiation block and can be grown as murine erythroleukemia (MEL) cell lines. In this study, we examined SFFV MEL cells to determine whether their transformed phenotype was associated with a block in the activation of any Epo signal-transducing molecules. Our studies indicate that Epo- or SFFV-induced activation of STAT1/3 DNA binding activity is blocked in SFFV MEL cells. The block is at the level of tyrosine phosphorylation of STAT1, although Jak2 phosphorylation is not blocked in these cells. In contrast to Epo, alpha interferon can induce STAT1 phosphorylation and DNA binding in SFFV MEL cells. The SFFV-transformed cells were shown to express elevated levels of the hematopoietic phosphatase SHP-1, and treatment of the cells with a phosphatase inhibitor restored STAT1 tyrosine phosphorylation. MEL cells derived from Friend murine leukemia virus (MuLV) or ME26 MuLV-infected mice, which do not express PU.1, express lower levels of SHP-1 and are not blocked in STAT1/3 DNA-binding activity. Our studies suggest that SFFV-infected erythroid cells become transformed when differentiation signals activated by STAT1/3 are blocked due to high SHP-1 levels induced by inappropriate expression of the PU.1 protein. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEUKEMIA
KW - GLYCOPROTEINS
KW - MOLECULES
KW - PROTEIN-tyrosine kinase
KW - CELLS
N1 - Accession Number: 21280747; Nishigaki, Kazuo 1,2 Hanson, Charlotte 1 Ohashi, Takashi 1,3 Spadaccini, Angelo 1,4 Ruscetti, Sandra 1; Email Address: ruscetti@ncifcrf.gov; Affiliation: 1: Laboratory of Cancer Prevention, National Cancer Institute--Frederick, Frederick, Maryland 2: Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo 113-8519, Japan 3: Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan 4: Office of Vaccines Research and Review, Division of Viral Products, Center for Biologics Evaluation and Research, Bethesda, MD 20892; Source Info: Jun2006, Vol. 80 Issue 12, p16; Subject Term: LEUKEMIA; Subject Term: GLYCOPROTEINS; Subject Term: MOLECULES; Subject Term: PROTEIN-tyrosine kinase; Subject Term: CELLS; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.02651-05
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Portilla, D.
AU - Li, S.
AU - Nagothu, K. K.
AU - Megyesi, J.
AU - Kaissling, B.
AU - Schnackenberg, L.
AU - Safirstein, R. L.
AU - Beger, R. D.
T1 - Metabolomic study of cisplatin-induced nephrotoxicity.
JO - Kidney International
JF - Kidney International
Y1 - 2006/06/15/
VL - 69
IS - 12
M3 - Article
SP - 2194
EP - 2204
SN - 00852538
AB - We have shown that cisplatin inhibits fatty acid oxidation, and that fibrate treatment ameliorates renal function by preventing the inhibition of fatty acid oxidation and proximal tubule cell death. Urine samples of mice treated with single injection of cisplatin (20 mg/kg body weight) were collected for 3 days and analyzed by 1H—nuclear magnetic resonance (NMR) spectroscopy. In a separate group, urine samples of mice treated with peroxisome proliferator-activated receptor-α (PPARα) ligand WY were also analyzed by NMR after 2 days of cisplatin exposure. Biochemical analysis of endogenous metabolites was performed in serum, urine, and kidney tissue. Electron microscopic studies were carried out to examine the effects of PPARα ligand and cisplatin. Principal component analysis demonstrated the presence of glucose, amino acids, and trichloacetic acid cycle metabolites in the urine after 48 h of cisplatin administration. These metabolic alterations precede changes in serum creatinine. Biochemical studies confirmed the presence of glucosuria, but also demonstrated the accumulation of nonesterified fatty acids, and triglycerides in serum, urine, and kidney tissue, in spite of increased levels of plasma insulin. These metabolic alterations were ameliorated by the use of PPARα ligand. Electron microscopic analysis confirmed the protective effect of the fibrate on preventing cisplatin-mediated necrosis of the S3 segment of the proximal tubule. Our study shows that cisplatin-induces a unique NMR metabolic profile in urine of mice that developed acute renal failure, and confirms the protective effect of a fibrate class of PPARα ligands. We propose that the injury-induced metabolic profile may be used as a biomarker of cisplatin-induced nephrotoxicity.Kidney International (2006) 69, 2194–2204. doi:10.1038/sj.ki.5000433; published online 3 May 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CISPLATIN
KW - FATTY acids
KW - OXIDATION
KW - CELL death
KW - GLYCOSURIA
KW - NEPHROTOXICOLOGY
KW - acute renal failure
KW - metabolomics
KW - peroxisome proliferator activated receptor-α
N1 - Accession Number: 21091097; Portilla, D. 1; Email Address: portilladidier@uams.edu Li, S. 1 Nagothu, K. K. 1 Megyesi, J. 1 Kaissling, B. 2 Schnackenberg, L. 3 Safirstein, R. L. 1 Beger, R. D. 3; Affiliation: 1: Department of Internal Medicine, Division of Nephrology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA 2: Anatomical Institute, Division of Vegetative Anatomy, University of Zurich, Zurich, Switzerland 3: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA; Source Info: Jun2006, Vol. 69 Issue 12, p2194; Subject Term: CISPLATIN; Subject Term: FATTY acids; Subject Term: OXIDATION; Subject Term: CELL death; Subject Term: GLYCOSURIA; Subject Term: NEPHROTOXICOLOGY; Author-Supplied Keyword: acute renal failure; Author-Supplied Keyword: metabolomics; Author-Supplied Keyword: peroxisome proliferator activated receptor-α; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 11p; Illustrations: 2 Diagrams, 2 Charts, 11 Graphs; Document Type: Article
L3 - 10.1038/sj.ki.5000433
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Um, So Young
AU - Jung, Sung Hee
AU - Jung, Seo Jeong
AU - Kim, Joo Il
AU - Chung, Soo Youn
AU - Lee, Hwa Jeong
AU - Han, Sang Beom
AU - Choi, Sun Ok
T1 - Column-switching high-performance liquid chromatographic analysis of fluvastatin in rat plasma by direct injection
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2006/06/16/
VL - 41
IS - 4
M3 - Article
SP - 1458
EP - 1462
SN - 07317085
AB - Abstract: A column-switching high-performance liquid chromatographic (HPLC) method has been developed and validated for quantification of fluvastatin in rat plasma. Plasma samples were diluted with an equal volume of mobile phase, i.e. acetonitrile–5mM potassium phosphate buffer (pH 6.8) (15:85, v/v), and the mixture was directly injected onto the HPLC system. The analyte was enriched in a pre-treatment column, while endogenous components were eluted to waste. The analyte was then back-flushed onto an analytical column and quantified with fluorescence detection (λ ex =305nm; λ em =390nm). The standard curve for the drug was linear in the range 0.5–100ngmL−1 in rat plasma. The limit of quantitation for plasma was found to be 0.5ngmL−1. This method has been fully validated and shown to be specific, accurate and precise. The method is simple and rapid because of a minimized sample preparation and appears to be useful for the pharmacokinetic study of fluvastatin. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - ACETONITRILE
KW - FLUORESCENCE
KW - PHARMACOKINETICS
KW - Column-switching
KW - Direct injection
KW - Fluvastatin
KW - High-performance liquid chromatography (HPLC)
KW - Rat plasma
N1 - Accession Number: 20961043; Um, So Young 1 Jung, Sung Hee 1 Jung, Seo Jeong 1 Kim, Joo Il 1 Chung, Soo Youn 1 Lee, Hwa Jeong 2 Han, Sang Beom 3 Choi, Sun Ok 1; Email Address: sochoi@kfda.go.kr; Affiliation: 1: Division of Biopharmaceutics, Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, Nokbun-dong 5, Eunpyung-Ku, Seoul, Republic of Korea 2: College of Pharmacy, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Ku, Seoul, Republic of Korea 3: College of Pharmacy, ChungAng University, 221 Huksuk-Dong, Dongjak-Ku, Seoul, Republic of Korea; Source Info: Jun2006, Vol. 41 Issue 4, p1458; Subject Term: HIGH performance liquid chromatography; Subject Term: ACETONITRILE; Subject Term: FLUORESCENCE; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: Column-switching; Author-Supplied Keyword: Direct injection; Author-Supplied Keyword: Fluvastatin; Author-Supplied Keyword: High-performance liquid chromatography (HPLC); Author-Supplied Keyword: Rat plasma; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jpba.2006.03.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauder, Christian J.
AU - Vandenburgh, Kari M.
AU - Iskow, Rebecca C.
AU - Malik, Tahir
AU - Carbone, Kathryn M.
AU - Rubin, Steven A.
T1 - Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity
JO - Virology
JF - Virology
Y1 - 2006/06/20/
VL - 350
IS - 1
M3 - Article
SP - 48
EP - 57
SN - 00426822
AB - Abstract: Mumps virus is a highly neurotropic virus with evidence of central nervous system invasion (CNS) in approximately half of all cases of infection. In countries where live attenuated mumps virus vaccines were introduced, the number of mumps cases declined dramatically; however, recently, the safety of some vaccine strains has been questioned. For example, one of the most widely used vaccines, the Urabe AM9 strain, was causally associated with meningitis, leading to the withdrawal of this product from the market in several countries. This highlights the need for a better understanding of the attenuation process and the identification of markers of attenuation. To this end, we further attenuated the Urabe AM9 strain by serial passage in cell culture and compared the complete nucleotide sequences of the parental and passaged viruses. Interestingly, despite a dramatic decrease in virus virulence (as assayed in rats), the only genomic changes were in the form of changes in the level of genetic heterogeneity at specific genome sites, i.e., either selection of one nucleotide variant at positions where the starting material exhibited nucleotide heterogeneity or the evolution of an additional nucleotide to create a heterogenic site. This finding suggests that changes in the level of genetic heterogeneity at specific genome sites can have profound neurovirulence phenotypic consequences and, therefore, caution should be exercised when evaluating genetic markers of virulence or attenuation based only on a consensus sequence. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUMPS
KW - VIRUSES
KW - VACCINATION
KW - PAROTID glands -- Diseases
KW - Central nervous system
KW - Genetic heterogeneity
KW - Mumps virus
KW - Neuroattenuation
KW - Neurovirulence
KW - Quasispecies
KW - Rat model
KW - Urabe AM9
KW - Vaccine
N1 - Accession Number: 21132067; Sauder, Christian J. 1 Vandenburgh, Kari M. 1 Iskow, Rebecca C. 1 Malik, Tahir 1 Carbone, Kathryn M. 1 Rubin, Steven A.; Email Address: rubins@cber.fda.gov; Affiliation: 1: DVP/Office of Vaccines Research and Review, Center for Biologics, Evaluation and Research, Food and Drug Administration, Building 29A, Room 1A-21, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Jun2006, Vol. 350 Issue 1, p48; Subject Term: MUMPS; Subject Term: VIRUSES; Subject Term: VACCINATION; Subject Term: PAROTID glands -- Diseases; Author-Supplied Keyword: Central nervous system; Author-Supplied Keyword: Genetic heterogeneity; Author-Supplied Keyword: Mumps virus; Author-Supplied Keyword: Neuroattenuation; Author-Supplied Keyword: Neurovirulence; Author-Supplied Keyword: Quasispecies; Author-Supplied Keyword: Rat model; Author-Supplied Keyword: Urabe AM9; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.virol.2006.01.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Min Ding
AU - Rentian Feng
AU - Wang, Shiow V.
AU - Bowman, Linda
AU - Yongju Lu
AU - Yong Qian
AU - Vincent Castranova
AU - Bing-Hua Jiang
AU - Xianglin Shi
T1 - Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/06/23/
VL - 281
IS - 25
M3 - Article
SP - 17359
EP - 17368
SN - 00219258
AB - Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer, Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced ·OH and O2τ radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethyl-benz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVE- and TPA-induced transactivation of NF-κB and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor-α. These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumor xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumor cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - BLACKBERRIES
KW - DRUG therapy
KW - FRUIT
KW - VEGETABLES
N1 - Accession Number: 21638040; Min Ding 1; Email Address: mid5@cdc.gov Rentian Feng 1 Wang, Shiow V. 2 Bowman, Linda 1 Yongju Lu 1 Yong Qian 1 Vincent Castranova 1 Bing-Hua Jiang 3 Xianglin Shi 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Fruit Laboratory, Beltsville Agricultural Research Center, U. S. Department of Agriculture, Beltsville, Maryland 20705 3: Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia 26505; Source Info: 6/23/2006, Vol. 281 Issue 25, p17359; Subject Term: CANCER; Subject Term: BLACKBERRIES; Subject Term: DRUG therapy; Subject Term: FRUIT; Subject Term: VEGETABLES; NAICS/Industry Codes: 111334 Berry (except Strawberry) Farming; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 10p; Illustrations: 7 Black and White Photographs, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1074/jbc.M600861200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tangkittipaporn, Jiraporn
AU - Tangkittipaporn, Noppakhun
T1 - Evidence-based investigation of safety management competency, occupational risks and physical injuries in the Thai informal sector
JO - International Congress Series
JF - International Congress Series
Y1 - 2006/06/28/
VL - 1294
M3 - Article
SP - 39
EP - 42
SN - 05315131
AB - Abstract: The investigation was based on a matching between enterprises and workers. The purposes do not only aim to map the profiles of Thai informal sectors'' safety management competency, occupational risks and physical injuries encountered, but also aim to investigate the significant factors predicting enterprises'' business success and home workers'' occupational injuries. 979 handicraft home workers and 281 small-scale handicraft enterprises were surveyed from the cities of Chiangmai and Lumphun in northern Thailand. Structure interview questionnaire, objective risk assessment and self-report were used as research instruments. The findings argue that product-oriented management competency was more powerful than safety-oriented management competency in predicting business success. Further, occupational risks were mainly induced by low competency in safety management, and finally created damages to home workers'' physical health. The study supports that the applications of ergonomic principle, fitting the person to the job and fitting the job to the person, are not limited simply to workers working in manufacturing sectors or conventional offices but also applicable for those working at homes. The key findings also help to remind those involved in supporting informal sectors to provide a better learning process and a work-site wellness program as well as incentives for improving corporate and individual accountability for occupational injuries abatement and economic justice. [Copyright &y& Elsevier]
AB - Copyright of International Congress Series is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL safety
KW - INDUSTRIAL hygiene
KW - WORK-related injuries
KW - ENVIRONMENTAL health
KW - Occupational health
KW - Occupational risk
KW - Physical injury
KW - Safety management competency
N1 - Accession Number: 21517083; Tangkittipaporn, Jiraporn 1; Email Address: tangkit@chiangmai.ac.th Tangkittipaporn, Noppakhun 2; Email Address: npktangkit@yahoo.com; Affiliation: 1: Chiangmai University, Industrial/Organizational Psychology, Thailand 2: Khonkhan Sub-District Administration, Public Health Service Centre, Thailand; Source Info: Jun2006, Vol. 1294, p39; Subject Term: INDUSTRIAL safety; Subject Term: INDUSTRIAL hygiene; Subject Term: WORK-related injuries; Subject Term: ENVIRONMENTAL health; Author-Supplied Keyword: Occupational health; Author-Supplied Keyword: Occupational risk; Author-Supplied Keyword: Physical injury; Author-Supplied Keyword: Safety management competency; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ics.2006.03.074
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106215292
T1 - Post-acute dispositions of older adults hospitalized for depression.
AU - Morrow-Howell NL
AU - Proctor EK
AU - Blinne WR
AU - Rubin EH
AU - Saunders JA
AU - Rozario PA
Y1 - 2006/07//
N1 - Accession Number: 106215292. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Diagnostic and Statistical Manual (DSM-4), Axis 4 checklist; Brief Psychiatric Rating Scale (BPRS); Instrumental Activities of Daily Living Scale (IADL); Cumulative Illness Rating Scale for Geriatrics (CIRS-G); Global Assessment of Functioning Scale (GAF); OARS Multidimensional Functional Assessment Questionnaire (OMFAQ); Geriatric Depression Scale (GDS); Multnomah Community Ability scale (Barker). Grant Information: Supported by the Center for Mental Health Services Research, Washington University through an award from the National Institute of Mental Health (#5R24MH50857-04). NLM UID: 9705773.
KW - After Care -- Utilization
KW - Aged, Hospitalized
KW - Depression -- Rehabilitation
KW - Geriatric Psychiatry
KW - Readmission
KW - Academic Medical Centers
KW - Aged
KW - Checklists
KW - Chi Square Test
KW - Coefficient Alpha
KW - Cox Proportional Hazards Model
KW - Depression -- Psychosocial Factors
KW - Depression -- Therapy
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Geriatric Depression Scale
KW - Geriatric Functional Assessment -- Methods
KW - Hospitals, Urban
KW - Internal Consistency
KW - Interviews
KW - Male
KW - Mental Health Services -- Utilization
KW - Midwestern United States
KW - Multiple Regression
KW - Nursing Homes -- Utilization
KW - OARS Multidimensional Functional Assessment Questionnaire
KW - P-Value
KW - Patient Discharge
KW - Prospective Studies
KW - Psychological Tests
KW - Questionnaires
KW - Scales
KW - Telephone
KW - Treatment Outcomes
KW - United States
KW - Human
SP - 352
EP - 361
JO - Aging & Mental Health
JF - Aging & Mental Health
JA - AGING MENT HEALTH
VL - 10
IS - 4
CY - Oxfordshire,
PB - Routledge
AB - This study addressed factors associated with six-month post-acute dispositions (continuous community stay, medical hospitalization, psychiatric rehospitalization, nursing home placement, death) for older adults hospitalized for depression and discharged to the community. The sample included 199 older adults; and data were collected via medical records, interviews with discharge planners, patients, and family members. Over half of the sample remained in the community throughout the observation period; 23% experienced psychiatric re-admission and 10% entered a nursing home. Several factors associated with nursing home placement were identified: less improvement in depression during the hospitalization, lower Global Assessment of Functioning (GAF) scores at discharge; and less mental health service use in the post-acute period. Those at higher risk of psychiatric re-admission had more previous psychiatric hospitalizations and were marginally more likely to be married and have lower Brief Psychiatric Rating Scale (BPRS) scores at discharge. Differentiating those at risk for nursing home placement may be easier than differentiating those at risk of psychiatric readmission.
SN - 1360-7863
AD - Center of Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1196, St. Louis, MO 63130; morrow-howell@wustl.edu
U2 - PMID: 16798627.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106248020
T1 - Medication therapy management programs: forming a new cornerstone for quality and safety in Medicare.
AU - Smith SR
AU - Clancy CM
Y1 - 2006/07//Jul/Aug2006
N1 - Accession Number: 106248020. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9300756.
KW - Drug Therapy
KW - Medicare
KW - Quality Assurance
KW - Safety
KW - Insurance, Pharmaceutical Services
KW - United States
SP - 276
EP - 279
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 21
IS - 4
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 16849785.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, Kevin L.
AU - Lyman, Roberta L.
AU - Bodeis-Jones, Sonya M.
AU - White, David G.
T1 - Genetic diversity and antimicrobial susceptibility profiles among mastitis-causing Staphylococcus aureus isolated from bovine milk samples.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 2006/07//
VL - 67
IS - 7
M3 - Article
SP - 1185
EP - 1191
SN - 00029645
AB - Objective--To determine whether particular antimicrobial susceptibility profiles of bovine mastitis-causing Staphylococcus aureus isolates were associated with specific S aureus genotypes. Sample Population--357 S aureus isolates recovered from milk samples submitted for diagnostic bacteriologic testing from 24 dairy herds. Procedures--Antimicrobial susceptibility of S aureus isolates was assessed by determining minimum inhibitory concentrations (MICs) to 14 antimicrobial agents. After digestion of S aureus genomic DNA by Smal, electrophoretic patterns were obtained via pulsed-field gel electrophoresis (PFGE) and used to classify isolates into types. Gels were analyzed, and data were used to prepare dendrograms. Results--308 of 357 (86%) S aureus isolates were susceptible to all antimicrobials evaluated. Forty-nine S aureus isolates were resistant to 1 or more antimicrobials; of these isolates, 37 were resistant only to penicillin, 9 were resistant to penicillin and erythromycin, 2 were resistant to tetracycline, and 1 was resistant to erythromycin. Isolates were assigned to 7 PFGE types. An association was found between PFGE type and antimicrobial susceptibility profile. Organisms with resistance to at least one of the tested antimicrobial agents were identified in only 4 of the 7 types of S aureus. Conclusions and Clinical Relevance--Antimicrobial resistance was uncommon among the mastitis-causing S aureus isolates identified in the milk samples. A limited number of genotypes were associated with mastitis in these herds. Antimicrobial resistance phenotypes were associated with particular S aureus PFGE types; this association may have implications for future treatment and control of S aureus-associated mastitis in cattle. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Veterinary Research is the property of American Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASTITIS in cattle
KW - STAPHYLOCOCCUS aureus
KW - COWS
KW - CATTLE -- Diseases
KW - GENETIC polymorphisms
N1 - Accession Number: 21548656; Anderson, Kevin L. 1 Lyman, Roberta L. 1 Bodeis-Jones, Sonya M. 2 White, David G. 2; Affiliation: 1: Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606 2: Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708; Source Info: Jul2006, Vol. 67 Issue 7, p1185; Subject Term: MASTITIS in cattle; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: COWS; Subject Term: CATTLE -- Diseases; Subject Term: GENETIC polymorphisms; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Green, Brett J.
AU - Millecchia, Lyndell L.
AU - Blachere, Francoise M.
AU - Tovey, Euan R.
AU - Beezhold, Donald H.
AU - Schmechel, Detlef
T1 - Dual fluorescent halogen immunoassay for bioaerosols using confocal microscopy
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2006/07//
VL - 354
IS - 1
M3 - Article
SP - 151
EP - 153
SN - 00032697
N1 - Accession Number: 21071524; Green, Brett J. 1; Email Address: Brett.Green@cdc.hhs.gov Millecchia, Lyndell L. 2 Blachere, Francoise M. 1 Tovey, Euan R. 3 Beezhold, Donald H. 1 Schmechel, Detlef 1; Affiliation: 1: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA 3: Woolcock Institute of Medical Research, Sydney, NSW, Australia; Source Info: Jul2006, Vol. 354 Issue 1, p151; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.ab.2006.03.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buehler, Paul W.
AU - Boykins, Robert A.
AU - Norris, Scott
AU - Alayash, Abdu I.
T1 - Chemical Characterization of Diaspirin Cross-Linked Hemoglobin Polymerized with Poly(ethylene glycol).
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2006/07//7/1/2006
VL - 78
IS - 13
M3 - Article
SP - 4634
EP - 4641
SN - 00032700
AB - A lack of specificity associated with chemical modification methods used in the preparation of certain hemoglobin (Hb)-based oxygen carriers (HBOCs) may alter Hb structure and function, as amino acids located in critical regions (e.g., α-β interfaces and the 2,3-DPG binding pocket) may unintentionally be targeted. Hb protein surface modifications with various poly(ethylene glycol) (PEG) derivatives have been used as conjugating and polymerizing agents with the intent of improving reaction site specificity/reproducibility and ultimately reducing the untoward hypertensive response due to nitric oxide scavenging by smaller molecular size tetrameric species (i.e., 64 kDa) in HBOC solutions. Previous experiments performed in our laboratory have evaluated the influence of polymerization of diaspirin α-α cross-linked Hb (αα-DBBF-Hb) with a bifunctional modified PEG, bis(male-oylglycylamide) PEG (BMAA-PEG), in terms of oxygen carrying capacity, redox properties, hypertensive response, and renal clearance in rats. The data presented in this paper specifically evaluate the influence of BMAA-PEG on αα-DBBF-Hb (Poly-αα-DBBF-Hb) to identify molecular weight distribution, protein conformation, and site-specific modification, as well as to provide insight into the previously determined in vitro and in vivo functional and vasoactive characteristics of this HBOC. Chemical analysis performed herein reveals nonspecific modifications induced by BMAA-PEG that result in the full modification of αα-DBBF-Hb leaving no tetrameric cross-linked starting material in solution. These data are inconsistent with the continuing assumption that molecular size (i.e., 64 kDa) has a direct influence on HBOC-mediated vasoactivity and that other protective strategies should be considered to control blood pressure imbalances. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - MOLECULAR structure
KW - CHEMICAL structure
KW - POLYETHYLENE glycol
KW - POLYMERIZATION
KW - PROTEINS
KW - ETHYLENE glycols
KW - CHEMICAL reactions
KW - PHYSICAL & theoretical chemistry
N1 - Accession Number: 21579682; Buehler, Paul W. 1 Boykins, Robert A. 2 Norris, Scott 2 Alayash, Abdu I. 1; Email Address: alayash@cber.fda.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Food and Drug Administration (FDA), Bethesda, Maryland 20892 2: Laboratory of Biophysics, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892; Source Info: 7/1/2006, Vol. 78 Issue 13, p4634; Subject Term: HEMOGLOBIN; Subject Term: MOLECULAR structure; Subject Term: CHEMICAL structure; Subject Term: POLYETHYLENE glycol; Subject Term: POLYMERIZATION; Subject Term: PROTEINS; Subject Term: ETHYLENE glycols; Subject Term: CHEMICAL reactions; Subject Term: PHYSICAL & theoretical chemistry; Number of Pages: 8p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bhagwat, Arvind A.
AU - Tan, Jasmine
AU - Sharma, Manan
AU - Kothary, Mahendra
AU - Low, Sharon
AU - Tall, Ben D.
AU - Bhagwat, Medha
T1 - Functional Heterogeneity of RpoS in Stress Tolerance of Enterohemorrhagic Escherichia coli Strains.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/07//
VL - 72
IS - 7
M3 - Article
SP - 4978
EP - 4986
SN - 00992240
AB - The stationary-phase sigma factor (RpoS) regulates many cellular responses to environmental stress conditions such as heat, acid, and alkali shocks. On the other hand, mutations at the rpoS locus have frequently been detected among pathogenic as well as commensal strains of Escherichia coli. The objective of this study was to perform a functional analysis of the RpoS-mediated stress responses of enterohemorrhagic E. coli strains from food-borne outbreaks. E. coli strains belonging to serotypes O157:H7, O111:H11, and O26:H11 exhibited polymorphisms for two phenotypes widely used to monitor rpoS mutations, heat tolerance and glycogen synthesis, as well as for two others, alkali tolerance and adherence to Caco-2 cells. However, these strains synthesized the oxidative acid resistance system through an rpoS-dependent pathway. During the transition from mildly acidic growth conditions (pH 5.5) to alkaline stress (pH 10.2), cell survival was dependent on rpoS functionality. Some strains were able to overcome negative regulation by RpoS and induced higher β-galactosidase activity without compromising their acid resistance. There were no major differences in the DNA sequences in the rpoS coding regions among the tested strains. The heterogeneity of rpoS-dependent phenotypes observed for stress-related phenotypes was also evident in the Caco-2 cell adherence assay. Wild-type O157:H7 strains with native rpoS were less adherent than rpoS-complemented counterpart strains, suggesting that rpoS functionality is needed. These results show that some pathogenic E. coli strains can maintain their acid tolerance capability while compromising other RpoS-dependent stress responses. Such adaptation processes may have significant impact on a pathogen's survival in food processing environments, as well in the host's stomach and intestine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli O157:H7
KW - PATHOGENIC bacteria
KW - PATHOGENIC microorganisms
KW - HETEROGENEITY
KW - GENETIC polymorphisms
KW - STRESS tolerance (Psychology)
KW - STRAIN (Physiology)
KW - ENVIRONMENTAL engineering
KW - FUNCTIONAL analysis
N1 - Accession Number: 21653560; Bhagwat, Arvind A. 1; Email Address: bhagwata@ba.ars.usda.gov Tan, Jasmine 1,2 Sharma, Manan 3 Kothary, Mahendra 4 Low, Sharon 1,2 Tall, Ben D. 4 Bhagwat, Medha 5; Affiliation: 1: Produce Quality and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, Maiyland 20705-2350 2: School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, 535 Clement Road, Singapore 599489, Singapore 3: Food Technology and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, Maiyland 20705-2350 4: Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland 20708 5: National Center for Biotechnology Information, Bldg. 38A, National Institutes of Health, Bethesda, Matyland 20894; Source Info: Jul2006, Vol. 72 Issue 7, p4978; Subject Term: ESCHERICHIA coli O157:H7; Subject Term: PATHOGENIC bacteria; Subject Term: PATHOGENIC microorganisms; Subject Term: HETEROGENEITY; Subject Term: GENETIC polymorphisms; Subject Term: STRESS tolerance (Psychology); Subject Term: STRAIN (Physiology); Subject Term: ENVIRONMENTAL engineering; Subject Term: FUNCTIONAL analysis; Number of Pages: 9p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1128/AEM.02842-05
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106221505
T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002.
AU - Huang B
AU - Grant BF
AU - Dawson DA
AU - Stinson FS
AU - Chou SP
AU - Saha TD
AU - Goldstein RB
AU - Smith SM
AU - Ruan WJ
AU - Pickering RP
Y1 - 2006/07//Jul/Aug2006
N1 - Accession Number: 106221505. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, and in part by the Intramural Research Program of the National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism. NLM UID: 0372612.
KW - Mental Disorders -- Ethnology
KW - Substance Use Disorders -- Ethnology
KW - Adult
KW - Affective Disorders -- Epidemiology
KW - Alcoholism -- Ethnology
KW - Anxiety Disorders -- Epidemiology
KW - Comorbidity
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Diagnosis, Dual (Psychiatry)
KW - DSM
KW - Funding Source
KW - Odds Ratio
KW - P-Value
KW - Personality Disorders -- Epidemiology
KW - Prevalence
KW - Random Sample
KW - T-Tests
KW - Two-Tailed Test
KW - United States
KW - Human
SP - 252
EP - 257
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
JA - COMPR PSYCHIATRY
VL - 47
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0010-440X
AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA.
U2 - PMID: 16769298.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miles, John R.
AU - Cajina, Adán
T1 - The Corrections Initiative: A Collaborative Partnership.
JO - Corrections Today
JF - Corrections Today
Y1 - 2006/07//
VL - 68
IS - 4
M3 - Article
SP - 26
EP - 32
PB - American Correctional Association
SN - 01902563
AB - The article provides information on the national corrections demonstration project initiated by the U.S. Centers for Disease Control and Prevention and the U.S. Department of Health and Human Services in several U.S. states. The project involved jail, prison and juvenile settings. Models of linked networks of health services, including HIV/AIDS, hepatitis, and substance abuse prevention and treatment during and after incarceration, were to be developed and evaluated for replication.
KW - CORRECTIONS (Criminal justice administration)
KW - SUBSTANCE abuse
KW - AIDS (Disease)
KW - HEPATITIS
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 21852885; Miles, John R. 1,2 Cajina, Adán 3; Affiliation: 1: Executive director of programs, American Correctional Health Services Association 2: Senior associate, McKing Consulting, Atlanta 3: Senior statistician, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Md.; Source Info: Jul2006, Vol. 68 Issue 4, p26; Subject Term: CORRECTIONS (Criminal justice administration); Subject Term: SUBSTANCE abuse; Subject Term: AIDS (Disease); Subject Term: HEPATITIS; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 911220 Federal correctional services; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 3407
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Iralu, Jonathan
AU - Ying Bai
AU - Crook, Larry
AU - Tempest, Bruce
AU - Simpson, Gary
AU - McKenzie, Taylor
AU - Koster, Frederick
AU - Bai, Ying
T1 - Rodent-associated Bartonella febrile illness, Southwestern United States.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006/07//
VL - 12
IS - 7
M3 - journal article
SP - 1081
EP - 1086
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Serum specimens from 114 patients hospitalized with a febrile illness were tested with an indirect immunofluorescence assay (IFA) using Bartonella antigens prepared from 6 species of sigmodontine rodents and 3 known human Bartonella pathogens: B. henselae, B. quintana, and B. elizabethae. Acute- and convalescent-phase serum samples from 5 of these patients showed seroconversion with an IFA titer >512 to rodent-associated Bartonella antigens. The highest titer was against antigen derived from the white-throated woodrat (Neotoma albigula), although this rodent is not necessarily implicated as the source of infection. Three of the 5 who seroconverted showed no cross-reaction to the 3 Bartonella human pathogens. Common clinical characteristics were fever, chills, myalgias, leukopenia, thrombocytopenia, and transaminasemia. Although antibodies to Bartonella are cross-reactive, high-titer seroconversions to rodent-associated Bartonella antigens in adults with common clinical characteristics should stimulate the search for additional Bartonella human pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Serum
KW - Hospital patients
KW - Immunofluorescence
KW - Bartonella
N1 - Accession Number: 21352625; Iralu, Jonathan 1; Ying Bai 2; Crook, Larry 1; Tempest, Bruce 1; Simpson, Gary 3; McKenzie, Taylor 4; Koster, Frederick 5,6; Email Address: fkoster@lrri.org; Bai, Ying; Affiliations: 1: US Public Health Service, Gallup, New Mexico, USA; 2: University of Colorado, Boulder, Colorado, USA; 3: New Mexico Department of Health, Santa Fe, New Mexico, USA; 4: The Navajo Nation, Window Rock, Arizona, USA; 5: University of New Mexico Health Science Center, Albuquerque, New Mexico, USA; 6: Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA; Issue Info: Jul2006, Vol. 12 Issue 7, p1081; Thesaurus Term: Antigens; Subject Term: Serum; Subject Term: Hospital patients; Subject Term: Immunofluorescence; Subject Term: Bartonella; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: journal article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hartley, David M.
AU - Klontz, Karl C.
AU - Ryan, Patricia
AU - Morris Jr., J. Glenn
AU - Morris, J Glenn Jr
T1 - Shigellosis and cryptosporidiosis, Baltimore, Maryland.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006/07//
VL - 12
IS - 7
M3 - commentary
SP - 1164
EP - 1165
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Presents a letter to the editor about shigellosis and cryptosporidiosis.
KW - Cryptosporidiosis
KW - Letters to the editor
KW - Disasters
KW - Seasons
KW - Shigellosis
KW - Maryland
N1 - Accession Number: 21352646; Hartley, David M. 1; Email Address: dhartley@epi.umaryland.edu; Klontz, Karl C. 2,3; Ryan, Patricia 4; Morris Jr., J. Glenn 1; Morris, J Glenn Jr; Affiliations: 1: University of Maryland School of Medicine, Baltimore, Maryland, USA; 2: The George Washington University School of Public Health and Health Services, Washington, DC, USA; 3: US Food and Drug Administration, College Park, Maryland, USA; 4: Maryland Department of Health and Mental Hygiene, Baltimore, Maryland, USA; Issue Info: Jul2006, Vol. 12 Issue 7, p1164; Thesaurus Term: Cryptosporidiosis; Subject Term: Letters to the editor; Subject Term: Disasters; Subject Term: Seasons; Subject Term: Shigellosis; Subject: Maryland; Number of Pages: 2p; Document Type: commentary
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McLean, David
AU - Pearce, Neil
AU - Langseth, Hilde
AU - Jäppinen, Paavo
AU - Szadkowska-Stanczyk, Irena
AU - Persson, Bodil
AU - Wild, Pascal
AU - Kishi, Reiko
AU - Lynge, Elsebeth
AU - Henneberger, Paul
AU - Sala, Maria
AU - Teschke, Kay
AU - Kauppinen, Timo
AU - Colin, Didier
AU - Kogevinas, Manolis
AU - Boffetta, Paolo
T1 - Cancer Mortality in Workers Exposed to Organochlorine Compounds in the Pulp and Paper Industry: An International Collaborative Study.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/07//
VL - 114
IS - 7
M3 - Article
SP - 1007
EP - 1012
PB - Superintendent of Documents
SN - 00916765
AB - The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed between 1920 and 1996 in 11 countries. Exposure to both volatile and nonvolatile organochlorine compounds was estimated at the department level using an exposure matrix. We conducted a standardized mortality ratio (SMR) analysis based on age and calendar-period-specific national mortality rates and a Poisson regression analysis. The study population consisted of 60,468 workers. Workers exposed to volatile organochlorines experienced a deficit of all-cause [SMR = 0.91; 95% confidence interval (CI), 0.89–0.93] and all-cancer (SMR = 0.93; 95% CI, 0.89–0.97) mortality, with no evidence of increased risks for any cancer of a priori interest. There was a weak, but statistically significant, trend of increasing risk of all-cancer mortality with increasing weighted cumulative exposure. A similar deficit in all-cause (SMR = 0.94; 95% CI, 0.91–0.96) and all-cancer (SMR = 0.94; 95% CI, 0.89–1.00) mortality was observed in those exposed to nonvolatile organochlorines. No excess risk was observed in cancers of a priori interest, although mortality from Hodgkin disease was elevated (SMR = 1.76; 95% CI, 1.02–2.82). In this study we found little evidence that exposure to organochlorines at the levels experienced in the pulp and paper industry is associated with an increased risk of cancer, apart from a weak but significant association between all-cancer mortality and weighted cumulative volatile organochlorine exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pulp mills
KW - Paper industry
KW - Environmental health research
KW - Cancer -- Mortality
KW - Organochlorine compounds
KW - Paper industry workers
KW - Poisson's equation
KW - Regression analysis
KW - Mathematical statistics
KW - epidemiology
KW - mortality
KW - neoplasms
KW - organochlorines
KW - pulp & paper industry
N1 - Accession Number: 21722375; McLean, David 1,2; Pearce, Neil 2; Langseth, Hilde 3; Jäppinen, Paavo 4; Szadkowska-Stanczyk, Irena 5; Persson, Bodil 6; Wild, Pascal 7; Kishi, Reiko 8; Lynge, Elsebeth 9; Henneberger, Paul 10; Sala, Maria 11; Teschke, Kay 12; Kauppinen, Timo 13; Colin, Didier 1; Kogevinas, Manolis 11; Boffetta, Paolo 1; Email Address: boffetta@iarc.fr; Affiliations: 1: International Agency for Research on Cancer, Lyon, France; 2: Center for Public Health Research, Massey University, Wellington, New Zealand; 3: Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; 4: Stora Enso Oyj, Imatra, Finland; 5: Nofer Institute of Occupational Medicine, Lodz, Poland; 6: Department of Occupational and Environmental Medicine, University Hospital, Linköping, Sweden; 7: Institut National de Recherche et de Sécurité, National Research and Safety Institute, Department of Epidemiology, Vandoeuvre, France; 8: Department of Public Health, Hokkaido University Graduate School of Medicine, Hokkaido, Japan; 9: University of Copenhagen, Copenhagen, Denmark; 10: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 11: Municipal Institute of Medical Research, Barcelona, Spain; 12: University of British Columbia, Vancouver, Canada; 13: Finnish Institute of Occupational Health, Helsinki, Finland; Issue Info: Jul2006, Vol. 114 Issue 7, p1007; Thesaurus Term: Pulp mills; Thesaurus Term: Paper industry; Thesaurus Term: Environmental health research; Subject Term: Cancer -- Mortality; Subject Term: Organochlorine compounds; Subject Term: Paper industry workers; Subject Term: Poisson's equation; Subject Term: Regression analysis; Subject Term: Mathematical statistics; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: mortality; Author-Supplied Keyword: neoplasms; Author-Supplied Keyword: organochlorines; Author-Supplied Keyword: pulp & paper industry; NAICS/Industry Codes: 424110 Printing and Writing Paper Merchant Wholesalers; NAICS/Industry Codes: 424130 Industrial and Personal Service Paper Merchant Wholesalers; NAICS/Industry Codes: 322121 Paper (except Newsprint) Mills; NAICS/Industry Codes: 322111 Mechanical pulp mills; NAICS/Industry Codes: 236210 Industrial Building Construction; NAICS/Industry Codes: 322130 Paperboard Mills; NAICS/Industry Codes: 322112 Chemical pulp mills; NAICS/Industry Codes: 322122 Newsprint Mills; NAICS/Industry Codes: 322110 Pulp Mills; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.8588
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yamaguchi, Yuji
AU - Takahashi, Kaoruko
AU - Zmudzka, Barbara Z.
AU - Komhauser, Andrija
AU - Miller, Sharon A.
AU - Tadokoro, Taketsugu
AU - Berens, Werner
AU - Beer, Janusz Z.
AU - Hearing, Vincent J.
T1 - Human skin responses to UV radiation: Pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2006/07//
VL - 20
IS - 9
M3 - Article
SP - 1486
EP - 1488
AB - Investigates DNA damage in the upper and lower epidermal layers in various types of skin before and after exposure to ultraviolet (UV) radiation. Role of melanin in protecting the skin against UV radiation; Measurement of apoptosis and phosphorylation of p53; Major mechanisms which underlie the difference sin photocarcinogenesis of light versus dark skin.
KW - DNA damage
KW - EPIDERMIS
KW - SKIN
KW - ULTRAVIOLET radiation
KW - MELANINS
KW - APOPTOSIS
KW - PHOSPHORYLATION
N1 - Accession Number: 21715932; Yamaguchi, Yuji 1 Takahashi, Kaoruko 1 Zmudzka, Barbara Z. 2 Komhauser, Andrija 3 Miller, Sharon A. 2 Tadokoro, Taketsugu 1 Berens, Werner 1 Beer, Janusz Z. 2 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 2: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA 3: Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, College Park, Maryland, USA; Source Info: Jul2006, Vol. 20 Issue 9, p1486; Subject Term: DNA damage; Subject Term: EPIDERMIS; Subject Term: SKIN; Subject Term: ULTRAVIOLET radiation; Subject Term: MELANINS; Subject Term: APOPTOSIS; Subject Term: PHOSPHORYLATION; Number of Pages: 3p; Illustrations: 3 Color Photographs; Document Type: Article
L3 - 10.1096/fj.06-5725fje
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21715932&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Limm, W.
AU - Begley, T. H.
AU - Lickly, T.
AU - Hentges, S. G.
T1 - Diffusion of limonene in polyethylene.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2006/07//
VL - 23
IS - 7
M3 - Article
SP - 738
EP - 746
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Diffusion coefficients of limonene in various linear low-density polyethylene (LLDPE) and low-density polyethylene (LDPE) resins have been determined from sorption data using a thermogravimetric methodology. From these data, one can determine whether polymer synthesis parameters such as the choice of catalytic process or co-monomer result in substantial differences in how much food packaging additives might migrate to food. For example, LLDPE is currently manufactured using either one of two distinct catalytic processes: Ziegler–Natta (ZN) and metallocene, a single-site catalyst. ZN catalysis is a heterogeneous process that has dominated polyolefin synthesis over the last half-century. It involves a transition metal compound containing a metal-carbon bond that can handle repeated insertion of olefin units. In contrast, metallocene catalysis has fewer than 20 years of history, but has generated much interest due to its ability to produce highly stereospecific polymers at a very high yield. In addition to high stereospecificity, metallocene-catalysed polymers are significantly lower in polydispersity than traditional ZN counterparts. Absorption and desorption testing of heat-pressed films made from LLDPE and LDPE resins of varying processing parameters indicates that diffusion coefficients of limonene in these resins do not change substantially. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polyethylene
KW - Low density polyethylene
KW - Food -- Packaging
KW - Food additives
KW - Food science
KW - Alkenes
KW - Thermogravimetry
KW - Gravimetric analysis
KW - Thermal analysis
KW - diffusion
KW - food-contact materials
KW - Migration
KW - packaging
N1 - Accession Number: 21076842; Limm, W. 1; Email Address: william.limm@fda.hhs.gov; Begley, T. H. 1; Lickly, T. 2; Hentges, S. G. 3; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration (HFS-245), 5100 Paint Branch Parkway, College Park, MD 20740, USA; 2: Dow Chemical Company, Midland, MI 48674, USA; 3: American Plastics Council, 1300 Wilson Blvd., Suite 800, Arlington, VA 22209, USA; Issue Info: Jul2006, Vol. 23 Issue 7, p738; Thesaurus Term: Polyethylene; Thesaurus Term: Low density polyethylene; Thesaurus Term: Food -- Packaging; Thesaurus Term: Food additives; Thesaurus Term: Food science; Thesaurus Term: Alkenes; Subject Term: Thermogravimetry; Subject Term: Gravimetric analysis; Subject Term: Thermal analysis; Author-Supplied Keyword: diffusion; Author-Supplied Keyword: food-contact materials; Author-Supplied Keyword: Migration; Author-Supplied Keyword: packaging; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 9p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/02652030600654408
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DB - eih
ER -
TY - JOUR
AU - Choi, Don Woong
AU - Kim, Jee Yeun
AU - Choi, Seon Hee
AU - Jung, Hee Su
AU - Kim, Hyo Joo
AU - Cho, So Yean
AU - Kang, Chan Soon
AU - Chang, Seung Yeup
T1 - Identification of steroid hormones in pomegranate (Punica granatum) using HPLC and GC–mass spectrometry
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2006/07//
VL - 96
IS - 4
M3 - Article
SP - 562
EP - 571
SN - 03088146
AB - Abstract: Although it has been known that pomegranate (Punica granatum L.) contains several steroid hormones, concrete experimental proofs about that have not been published until now. In order to identify and evaluate the contents of steroid hormones including estrone in pomegranate, we analyzed pomegranate seed, fruit juice and commercial preparations. We developed a reproducible and sensitive method for separation and identification of steroid hormones in pomegranate samples using both high performance liquid chromatography (HPLC)–PDA and gas chromatography (GC)–MS. In case of HPLC, an isocratic elution method using 35% aqueous acetonitrile solution at 1.0ml/min with photodiode-array (PDA) detection at 225nm and 254nm was found to optimally separate and identify the steroid hormones from the pomegranate samples with a run time of less than 30min. The pomegranate samples were comparatively analyzed to the HPLC results by GC/FID or GC/MS detection on a HP-1 (30m length, 0.32mm I.D.) with helium as carrier gas under the oven temperature control as follows: start 220°C for 5min, raising 5°C per min, final 280°C for 10min. The HPLC and GC methods were successfully applied to the identification of steroid hormones in pomegranate samples. Our results suggested that there were no steroid estrogens including estrone, estradiol and testosterone in pomegranate seed, fruit juice and preparations. Consequently, we assumed that the previously reported analysts of pomegranate were misunderstood their analytical results according to either the estrogen-like effects or similarity of peak retention time and Rf values in experiments. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POMEGRANATE
KW - FOOD -- Analysis
KW - MASS spectrometry
KW - CHROMATOGRAPHIC analysis
KW - Estrone
KW - GC/MS
KW - HPLC–PDA
KW - Pomegranate
KW - Steroid estrogens
KW - Testosterone
N1 - Accession Number: 19139754; Choi, Don Woong 1; Email Address: cdwkje@kfda.go.kr Kim, Jee Yeun 1 Choi, Seon Hee 1 Jung, Hee Su 1 Kim, Hyo Joo 2 Cho, So Yean 3 Kang, Chan Soon 1 Chang, Seung Yeup 3; Affiliation: 1: Office of Analysis Evaluation, Korea Food and Drug Administration (KFDA), Eunpyung-Gu, Seoul 122-704, Korea 2: Center of Quality Control and Assurance, Ilhwa Corp., 1 Sootaek-Dong, Guri City, Gyunggi Province 471-711, Korea 3: Division of Natural Medicines Standardization, Korea Food and Drug Administration (KFDA), Seoul 122-704, Korea; Source Info: Jul2006, Vol. 96 Issue 4, p562; Subject Term: POMEGRANATE; Subject Term: FOOD -- Analysis; Subject Term: MASS spectrometry; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Estrone; Author-Supplied Keyword: GC/MS; Author-Supplied Keyword: HPLC–PDA; Author-Supplied Keyword: Pomegranate; Author-Supplied Keyword: Steroid estrogens; Author-Supplied Keyword: Testosterone; NAICS/Industry Codes: 111330 Non-citrus fruit and tree nut farming; NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.foodchem.2005.03.010
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DB - aph
ER -
TY - JOUR
AU - Ayaz, Faik A.
AU - Glew, Robert H.
AU - Millson, M.
AU - Huang, H.S.
AU - Chuang, L.T.
AU - Sanz, Carlos
AU - Hayırlıoglu-Ayaz, S.
T1 - Nutrient contents of kale (Brassica oleraceae L. var. acephala DC.)
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2006/07//
VL - 96
IS - 4
M3 - Article
SP - 572
EP - 579
SN - 03088146
AB - Abstract: Fructose, glucose and sucrose, as the major soluble sugars and citric and malic acids, as the major organic acids, were identified and determined in kale (Brassica oleraceae L. var. acephala DC., black cabbage) leaves. Fructose was the predominant sugar (2011 mg100 g−1 dry wt) identified, followed by glucose (1056 mg100 g−1 dry wt) and sucrose (894 mg100 g−1 dry wt). The contents of citric and malic acids were at 2213 and 151 mg100 g−1 dry wt in the leaves. The 16:0, 18:2n −6 and 18:3n −3 fatty acids were the most abundant fatty acids in the leaves. Considering the level of these fatty acids, 18:3n −3 was found to be the highest (85.3 μgg−1 dry wt), contributing 54.0% of the total fatty acid content. Linoleic acid (18:2n −6), being the second most abundant fatty acid was present at 18.6 μgg−1 dry wt, contributing 11.8% of the total fatty acid content. In the seed oil of kale, 22:1n −9 was the most abundant fatty acid (4198 μgg−1 dry wt, 45.7%), with 18:2n −6 (1199 μgg−1 dry wt, 12.3%) and 18:1n −9 (1408 μgg−1 dry wt, 14.8%) being the second next most abundant fatty acids. The most abundant amino acid was glutamic acid (Glu) which was present at 33.2 mgg−1 dry wt. Aspartic acid, which was the second most abundant amino acid, was present at 27.6 mgg−1 dry wt and accounted for 10.2% of the total amino acid content of kale leaf. The amino acid content was assessed by comparing the percentages of the essential amino acids in kale leaf versus those of a World Health Organization (WHO) standard protein. The protein of kale leaf compares well with that of the WHO standard. Only one amino acid, lysine, had a score that fell below 100%; the lysine score of kale leaf was 95%. This study attempts to contribute to knowledge of the nutritional properties of the plant. These results may be useful for the evaluation of dietary information. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION -- Requirements
KW - FATTY acids
KW - ESSENTIAL fatty acids
KW - FOOD -- Analysis
KW - Acid
KW - Amino acid
KW - Black cabbage
KW - Brassica oleraceae var. acephala
KW - Fatty acid
KW - Kale
KW - Mineral
KW - Sugar
N1 - Accession Number: 19139755; Ayaz, Faik A. 1 Glew, Robert H. 2; Email Address: rglew@salud.unm.edu Millson, M. 3 Huang, H.S. 4 Chuang, L.T. 4 Sanz, Carlos 5 Hayırlıoglu-Ayaz, S. 1; Affiliation: 1: Department of Biology, Karadeniz Technical University, 61080 Trabzon, Turkey 2: Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC08 4670, Albuquerque, NM 87131, USA 3: National Institute of Occupational Safety and Health, Cincinnati, OH, USA 4: Ross Products Division, Abbott Laboratories, Colombus, OH, USA 5: Instituto de la Grasa, CSIC, Department of Physiology and Technology of Plant Products Padre García Tejero 4, 41012-Seville, Spain; Source Info: Jul2006, Vol. 96 Issue 4, p572; Subject Term: NUTRITION -- Requirements; Subject Term: FATTY acids; Subject Term: ESSENTIAL fatty acids; Subject Term: FOOD -- Analysis; Author-Supplied Keyword: Acid; Author-Supplied Keyword: Amino acid; Author-Supplied Keyword: Black cabbage; Author-Supplied Keyword: Brassica oleraceae var. acephala; Author-Supplied Keyword: Fatty acid; Author-Supplied Keyword: Kale; Author-Supplied Keyword: Mineral; Author-Supplied Keyword: Sugar; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.foodchem.2005.03.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106141688
T1 - Sustaining and improving hospital performance: the effects of organizational and market factors.
AU - Jiang HJ
AU - Friedman B
AU - Begun JW
Y1 - 2006/07//Jul-Sep2006
N1 - Accession Number: 106141688. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 7611530.
KW - Clinical Indicators
KW - Economic Competition
KW - Health Facility Administration -- Standards
KW - Hospitals -- Evaluation
KW - Conceptual Framework
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Funding Source
KW - Health Facility Administration -- Economics
KW - Hospital Mortality
KW - Logistic Regression
KW - Organizational Efficiency
KW - P-Value
KW - T-Tests
KW - United States
KW - Human
SP - 188
EP - 196
JO - Health Care Management Review
JF - Health Care Management Review
JA - HEALTH CARE MANAGE REV
VL - 31
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Using data from hospitals in ten states, this study examines the effects of organizational and market factors on the likelihood of becoming high-quality/low-cost providers during the period of 1997-2001. The findings highlight the important role of previous performance, internal operations, and market competition in hospital performance improvement. Achieving high-quality/low-cost performance is also incidentally found to be associated with improved profit margins.
SN - 0361-6274
AD - Social Scientist, Center for Delivery, Organizaton and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland; joanna.jiang@ahrq.gov
U2 - PMID: 16877886.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106107100
T1 - A transdisciplinary approach to improve health literacy and reduce disparities.
AU - Lloyd LLJ
AU - Ammary NJ
AU - Epstein LG
AU - Johnson R
AU - Rhee K
Y1 - 2006/07//
N1 - Accession Number: 106107100. Language: English. Entry Date: 20070622. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 100890609.
KW - Health Education
KW - Health Services Accessibility
KW - Interprofessional Relations
KW - Health Literacy
KW - Community Health Centers
KW - Diabetes Mellitus
KW - Patient Education
KW - Physician-Patient Relations
KW - Self Care
KW - United States
SP - 331
EP - 335
JO - Health Promotion Practice
JF - Health Promotion Practice
JA - HEALTH PROMOT PRACT
VL - 7
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - A challenge to public health professionals, health care providers, and consumers is to come together to improve the quality of health care and to eliminate disparities. Improving health literacy skills along with a transdisciplinary approach to care contributes to effective patient-provider communication. This article addresses a team approach to health care, a community health center experience, self-management skills, patient education, and cultural competency training. In addition, the authors provide concepts that can be incorporated in health care settings to eliminate health disparities and improve health literacy.
SN - 1524-8399
AD - Center for Quality at the Health Resources and Services Administration, Rockville, Maryland, USA.
U2 - PMID: 16760237.
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DB - rzh
ER -
TY - JOUR
AU - Shirota, Hidekazu
AU - Ishii, Ken J.
AU - Takakuwa, Hiroki
AU - Klinman, Dennis M.
T1 - Contribution of interferon-β to the immune activation induced by double-stranded DNA.
JO - Immunology
JF - Immunology
Y1 - 2006/07//
VL - 118
IS - 3
M3 - Article
SP - 302
EP - 310
PB - Wiley-Blackwell
SN - 00192805
AB - Introducing double-stranded DNA (dsDNA) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (APCs). This process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. Current findings indicate that interferon-β (IFN-β) plays a key role in the stimulatory cascade triggered by dsDNA. Both immune and non-immune cells respond to intracytoplasmic dsDNA by up-regulating IFN-β) expression, a process that reduces host susceptibility to infection. The immune activation induced by dsDNA is independent of MyD88, TRIF and DNA-PKcs, indicating that a Toll-like receptor-independent mechanism underlies the cellular activation mediated by intracytoplasmic dsDNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - DNA
KW - ANTIGEN presenting cells
KW - DENDRITIC cells
KW - CYTOKINES
KW - CHEMOKINES
KW - host protection
KW - Toll-like receptor
KW - type 1 IFNs
N1 - Accession Number: 21217490; Shirota, Hidekazu 1 Ishii, Ken J. 2 Takakuwa, Hiroki 3 Klinman, Dennis M. 1; Email Address: klinman@cber.fda.gov; Affiliation: 1: Section of Retroviral Immunology, ERATO, Japan Science and Technology Agency, Osaka University, Osaka, Japan 2: Department of Host Defense, Research Institute for Microbial Diseases, ERATO, Japan Science and Technology Agency, Osaka University, Osaka, Japan 3: Laboratory of DNA Viruses, Center for Biologics Evaluation and Research, US Food and Drug Administration, Betheda, MD USA; Source Info: Jul2006, Vol. 118 Issue 3, p302; Subject Term: INTERFERONS; Subject Term: DNA; Subject Term: ANTIGEN presenting cells; Subject Term: DENDRITIC cells; Subject Term: CYTOKINES; Subject Term: CHEMOKINES; Author-Supplied Keyword: host protection; Author-Supplied Keyword: Toll-like receptor; Author-Supplied Keyword: type 1 IFNs; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2567.2006.02367.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Forester, Crystal D.
AU - Ham, Jason E.
AU - Wells, J. R.
T1 - Gas-phase chemistry of dihydromyrcenol with ozone and OH radical: Rate constants and productsThe findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health
JO - International Journal of Chemical Kinetics
JF - International Journal of Chemical Kinetics
Y1 - 2006/07//
VL - 38
IS - 7
M3 - Article
SP - 451
EP - 463
SN - 05388066
AB - A bimolecular rate constant, kOH + dihydromyrcenol, of (38 ± 9) × 10-12 cm3 molecule-1 s-1 was measured using the relative rate technique for the reaction of the hydroxyl radical (OH) with 2,6-dimethyl-7-octen-2-ol (dihydromyrcenol,) at 297 ± 3 K and 1 atm total pressure. Additionally, an upper limit of the bimolecular rate constant, kO3 + dihydromyrcenol, of approximately 2 × 10-18 cm3 molecule-1 s-1 was determined by monitoring the decrease in ozone (O3) concentration in an excess of dihydromyrcenol. To more clearly define part of dihydromyrcenol's indoor environment degradation mechanism, the products of the dihydromyrcenol + OH and dihydromyrcenol + O3 reactions were also investigated. The positively identified dihydromyrcenol/OH and dihydromyrcenol/O3 reaction products were acetone, 2-methylpropanal (O&dbond;CHCH(CH3)2), 2-methylbutanal (O&dbond;CHCH(CH3)CH2CH3), ethanedial (glyoxal, HC(&dbond;O)C(&dbond;O)H), 2-oxopropanal (methylglyoxal, CH3C(&dbond;O)C(&dbond;O)H). The use of derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) clearly indicated that several other reaction products were formed. The elucidation of these other reaction products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible dihydromyrcenol/OH and dihydromyrcenol/O3 reaction mechanisms based on previously published volatile organic compound/OH and volatile organic compound/O3 gas-phase reaction mechanisms. © 2006 Wiley Periodicals, Inc.* This article is a US Government work and, as such, is in the public domain of the United States of America Int J Chem Kinet 38: 451–463, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Chemical Kinetics is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICAL reactions
KW - HYDROXYL group
KW - REACTION mechanisms (Chemistry)
KW - ACETONE
KW - VOLATILE organic compounds
KW - RADICALS (Chemistry)
N1 - Accession Number: 21786477; Forester, Crystal D. 1 Ham, Jason E. 1 Wells, J. R. 1; Email Address: ozw0@cdc.gov; Affiliation: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health,1095 Willowdale Road, Morgantown, WV 26505; Source Info: Jul2006, Vol. 38 Issue 7, p451; Subject Term: CHEMICAL reactions; Subject Term: HYDROXYL group; Subject Term: REACTION mechanisms (Chemistry); Subject Term: ACETONE; Subject Term: VOLATILE organic compounds; Subject Term: RADICALS (Chemistry); NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 13p; Illustrations: 2 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1002/kin.20174
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Viswanathan, M.
AU - Jorgensen, M.J.
AU - Kittusamy, N.K.
T1 - Field evaluation of a continuous passive lumbar motion system among operators of earthmoving equipment
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2006/07//
VL - 36
IS - 7
M3 - Article
SP - 651
EP - 659
SN - 01698141
AB - Abstract: Operating heavy mobile construction equipment is often associated with elevated rates of low back discomfort. However, few formal studies have evaluated interventions that may reduce low back discomfort among these workers. The objective of this study was to determine the effectiveness of a continuous passive lumbar motion system (CPLMS), which is an additional lumbar seat support that can cyclically inflate and deflate, in reducing low back discomfort among operators of heavy earth-moving equipment. This was a quasi-experimental intervention study with multiple observations in which body part discomfort surveys were collected from an intervention and a control group during normal working days. The intervention group also completed a CPLMS preference survey after completing use of the CPLMS for 646h. Results from the body part discomfort survey showed no significant difference in low back discomfort between mornings and evenings for the first seven days, but a significant difference on the eighth and final day for the intervention group. In the control group, there was a significant difference between mornings and evenings on three out of five days for the low back discomfort score, where, the evening score was always higher than the morning score for all days. In addition, comparisons between the control and intervention groups indicated that the difference between morning and evening low back discomfort rating approached significance . The CPLMS preference survey showed that 54% of the operators felt very comfortable using the CPLMS, 36% wanted one for their equipment, and 54% showed interest in experimenting with the CPLMS for a longer time period. Results from this study suggest that the use of this intervention may effectively reduce the development rate of low back discomfort experienced by operators of heavy earth-moving equipment throughout the work day. Relevance to industry: This study indicates that providing an intervention that promotes dynamic changes and improving lumbar curvature during prolonged static sitting in a whole body vibration environment may have a positive effect by reducing the development rate of low back discomfort. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Construction equipment
KW - Construction workers
KW - Lumbar pain
KW - Back
KW - Low back discomfort
KW - Lumbar back support
KW - Operating engineers
KW - Static seating
KW - Whole body vibration
N1 - Accession Number: 21337582; Viswanathan, M. 1; Jorgensen, M.J. 1; Kittusamy, N.K. 2; Email Address: nfk8@cdc.gov; Affiliations: 1: Ergonomics and Occupational Biomechanics Laboratory, Wichita State University, 1845 N. Fairmount St., Wichita, KS 67260-0035, USA; 2: Spokane Research Laboratory, National Institute for Occupational Safety and Health, 315 E. Montgomery Ave., Spokane, WA 99207, USA; Issue Info: Jul2006, Vol. 36 Issue 7, p651; Thesaurus Term: DISEASES; Subject Term: Construction equipment; Subject Term: Construction workers; Subject Term: Lumbar pain; Subject Term: Back; Author-Supplied Keyword: Low back discomfort; Author-Supplied Keyword: Lumbar back support; Author-Supplied Keyword: Operating engineers; Author-Supplied Keyword: Static seating; Author-Supplied Keyword: Whole body vibration; NAICS/Industry Codes: 333120 Construction Machinery Manufacturing; NAICS/Industry Codes: 417210 Construction and forestry machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ergon.2006.04.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106353530
T1 - Emerging issues in occupational safety and health.
AU - Schulte PA
Y1 - 2006/07//2006 Jul
N1 - Accession Number: 106353530. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Occupational Health -- Trends
KW - Occupational Safety -- Trends
KW - Access to Information
KW - Epidemiological Research
KW - Occupational Diseases -- Economics
KW - Stress, Psychological
KW - World Health
SP - 273
EP - 277
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 12
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In developed countries, changes in the nature of work and the workforce may necessitate recalibrating the vision of occupational safety and health (OSH) researchers, practitioners, and policymakers to increase the focus on the most important issues. New methods of organizing the workplace, extensive labor contracting, expansion of service and knowledge sectors, increase in small business, aging and immigrant workers, and the continued existence of traditional hazards in high-risk sectors such as construction, mining, agriculture, health care, and transportation support the need to address: 1) broader consideration of the role and impact of work, 2) relationship between work and psychological dysfunction, 3) increased surveillance basis for research and intervention, 4) overcoming barriers to the con-duct and use of epidemiologic research, 5) information and knowledge transfer and application, 6) economic issues in prevention, and 7) the global interconnectedness of OSH. These issues are offered to spur thinking as new national research agendas for OSH are considered for developed countries.
SN - 1077-3525
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226-1922, U.S.A.
U2 - PMID: 16967836.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Choudhuri, Supratim
AU - Klaassen, Curtis D.
T1 - Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2006/07//
VL - 25
IS - 4
M3 - Article
SP - 231
EP - 259
PB - Taylor & Francis Ltd
SN - 10915818
AB - The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins, which transport a variety of compounds through the membrane against a concentration gradient at the cost of ATP hydrolysis. Substrates of the ABC transporters include lipids, bile acids, xenobiotics, and peptides for antigen presentation. As they transport exogenous and endogenous compounds, they reduce the body load of potentially harmful substances. One by-product of such protective function is that they also eliminate various useful drugs from the body, causing drug resistance. This review is a brief summary of the structure, function, and expression of the important drug resistance–conferring members belonging to three subfamilies of the human ABC family; these are ABCB1 (MDR1/P-glycoprotein of subfamily ABCB), subfamily ABCC (MRPs), and ABCG2 (BCRP of subfamily ABCG), which are expressed in various organs. In the text, the transporter symbol that carries the subfamily name (such as ABCB1, ABCC1, etc.) is used interchangeably with the corresponding original names, such as MDR1P-glycoprotein, MRP1, etc., respectively. Both nomenclatures are maintained in the text because both are still used in the transporter literature. This helps readers relate various names that they encounter in the literature. It now appears that P-glycoprotein, MRP1, MRP2, and BCRP can explain the phenomenon of multidrug resistance in all cell lines analyzed thus far. Also discussed are the gene structure, regulation of expression, and various polymorphisms in these genes. Because genetic polymorphism is thought to underlie interindividual differences, including their response to drugs and other xenobiotics, the importance of polymorphism in these genes is also discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacology
KW - Hydrolysis
KW - ATP-binding cassette transporters
KW - Membrane proteins
KW - P-glycoprotein
KW - Glycoproteins
KW - Genetic polymorphisms
KW - Drug resistance
KW - Lipids
KW - BCRP
KW - Expression
KW - Function
KW - Localization
KW - MDR
KW - MRP
KW - SNP
N1 - Accession Number: 21460048; Choudhuri, Supratim 1; Email Address: Supratim.Choudhuri@fda.hhs.gov; Klaassen, Curtis D. 2; Affiliations: 1: Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA; 2: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA; Issue Info: Jul2006, Vol. 25 Issue 4, p231; Thesaurus Term: Pharmacology; Thesaurus Term: Hydrolysis; Subject Term: ATP-binding cassette transporters; Subject Term: Membrane proteins; Subject Term: P-glycoprotein; Subject Term: Glycoproteins; Subject Term: Genetic polymorphisms; Subject Term: Drug resistance; Subject Term: Lipids; Author-Supplied Keyword: BCRP; Author-Supplied Keyword: Expression; Author-Supplied Keyword: Function; Author-Supplied Keyword: Localization; Author-Supplied Keyword: MDR; Author-Supplied Keyword: MRP; Author-Supplied Keyword: SNP; Number of Pages: 29p; Illustrations: 8 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1080/10915810600746023
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brzezinski, Jennifer L.
T1 - Detection of Cashew Nut DNA in Spiked Baked Goods Using a Real-Time Polymerase Chain Reaction Method.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/07//Jul/Aug2006
VL - 89
IS - 4
M3 - Article
SP - 1035
EP - 1038
SN - 10603271
AB - The article reports on the detection of cashew nut DNA in spiked baked goods using a real-time polymerase chain reaction method. The method amplifies a 67 bp fragment of the cashew 2S albumin gene, which is detected with a cashew-specific, dual-labeled TaqMan probe. Such reaction will not amplify DNA derived from other tree nut species and several varieties of peanut.
KW - CASHEW nut
KW - BAKED products
KW - DNA
KW - PLANT genetics
KW - GENE amplification
KW - POLYMERASE chain reaction
N1 - Accession Number: 21937278; Brzezinski, Jennifer L. 1; Email Address: jennifer.brzezinski@fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Dr, Cincinnati, OH 45237; Source Info: Jul/Aug2006, Vol. 89 Issue 4, p1035; Subject Term: CASHEW nut; Subject Term: BAKED products; Subject Term: DNA; Subject Term: PLANT genetics; Subject Term: GENE amplification; Subject Term: POLYMERASE chain reaction; NAICS/Industry Codes: 311821 Cookie and Cracker Manufacturing; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 445291 Baked Goods Stores; NAICS/Industry Codes: 311813 Frozen Cakes, Pies, and Other Pastries Manufacturing; NAICS/Industry Codes: 311812 Commercial Bakeries; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 111335 Tree Nut Farming; NAICS/Industry Codes: 311911 Roasted Nuts and Peanut Butter Manufacturing; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horwitz, William
AU - Albert, Richard
T1 - The Horwitz Ratio (HorRat): A Useful Index of Method Performance with Respect to Precision.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/07//Jul/Aug2006
VL - 89
IS - 4
M3 - Article
SP - 1095
EP - 1109
SN - 10603271
AB - The article investigates the efficacy of Horwitz ratio (HorRat) . HorRat is identified as a normalized performance parameter that indicates the acceptability of methods of analysis with respect to among-laboratory precision. It is recognized as one of the acceptability criteria of the recently adopted chemical methods of analysis of AOAC International, the European Union and other European organizations that deals with food analysis.
KW - FOOD -- Analysis
KW - FOOD -- Composition
KW - SANITARY chemistry
KW - AOAC International Inc.
KW - EUROPEAN Union
N1 - Accession Number: 21937288; Horwitz, William 1; Email Address: wxhor@aol.com Albert, Richard; Affiliation: 1: U.S. Food and Drug Administration; Source Info: Jul/Aug2006, Vol. 89 Issue 4, p1095; Subject Term: FOOD -- Analysis; Subject Term: FOOD -- Composition; Subject Term: SANITARY chemistry; Company/Entity: AOAC International Inc. Company/Entity: EUROPEAN Union; Number of Pages: 15p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delmonte, Pierluigi
AU - Rader, Jeanne I.
T1 - Analysis of Isoflavones in Foods and Dietary Supplements.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/07//Jul/Aug2006
VL - 89
IS - 4
M3 - Article
SP - 1138
EP - 1146
SN - 10603271
AB - The article aims to determine isoflavone, the phytochemicals found in many plants, derivatives based on the fragmentation pattern of the parent ion providing high selectivity and sensitivity in the quantitation of isoflavones in complex mixtures using high-performance liquid chromatography/tandem mass spectrometry. Daidzein, genistein and glycitein are recognized as free forms or derivatives in foods containing soy or soy protein extracts.
KW - ISOFLAVONES
KW - DIETARY supplements
KW - SOY proteins
KW - HIGH performance liquid chromatography
KW - PHYTOCHEMICALS
KW - MASS spectrometry
N1 - Accession Number: 21937294; Delmonte, Pierluigi 1; Email Address: pierluigi.delmonte@fda.hhs.gov Rader, Jeanne I. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling and Dietary Supplements, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Jul/Aug2006, Vol. 89 Issue 4, p1138; Subject Term: ISOFLAVONES; Subject Term: DIETARY supplements; Subject Term: SOY proteins; Subject Term: HIGH performance liquid chromatography; Subject Term: PHYTOCHEMICALS; Subject Term: MASS spectrometry; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Lee D.
AU - Twaddle, Nathan C.
AU - Churchwell, Mona I.
AU - Doerge, Daniel R.
T1 - Quantification of Tamoxifen and Metabolites and Soy Isoflavones in Human Plasma Using Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/07//Jul/Aug2006
VL - 89
IS - 4
M3 - Article
SP - 1168
EP - 1173
SN - 10603271
AB - The article describes the development and validation of a sensitive method using solid-phase extraction and isotope dilution liquid chromatography/tandem mass spectrometry with multiple reaction monitoring for the concurrent analysis of the major soy isoflavones, tamoxifen, and its important metabolites in the serum of rats and women. Tamoxifen is recognized as an important estrogen receptor antagonist used for the treatment and prevention of breast cancer.
KW - TAMOXIFEN
KW - ISOFLAVONES
KW - ESTROGEN receptors
KW - BREAST cancer
KW - RATS as laboratory animals
KW - ESTROGEN antagonists
KW - LIQUID chromatography
KW - MASS spectrometry
N1 - Accession Number: 21937297; Williams, Lee D. 1 Twaddle, Nathan C. 1 Churchwell, Mona I. 1 Doerge, Daniel R. 1; Email Address: daniel.doerge@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR 72079; Source Info: Jul/Aug2006, Vol. 89 Issue 4, p1168; Subject Term: TAMOXIFEN; Subject Term: ISOFLAVONES; Subject Term: ESTROGEN receptors; Subject Term: BREAST cancer; Subject Term: RATS as laboratory animals; Subject Term: ESTROGEN antagonists; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Perfield II, J. W.
AU - Delmonte, P.
AU - Lock, A. L.
AU - Yurawecz, M. P.
AU - Bauman, D. E.
T1 - Trans-10, Trans-12 Conjugated Linoleic Acid Does Not Affect Milk Fat Yield but Reduces Δ9-Desaturase Index in Dairy Cows.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2006/07//
VL - 89
IS - 7
M3 - Abstract
SP - 2559
EP - 2566
SN - 00220302
AB - Trans-10, cis-12 conjugated linoleic acid (CLA) is a potent inhibitor of milk fat synthesis, and the magnitude of milk fat depression is often correlated with the fat content of this isomer. However, the trans-10, cis-12 CLA content does not always correspond to the extent of milk fat depression, and in some instances, an increase in the milk fat content of trans-10, trans-12 CLA has been observed. We synthesized trans-10, trans-12 CLA (>90% purity) and investigated its effect on milk fat synthesis and incorporation into plasma lipids. Three rumen-fistulated Holstein cows were randomly assigned in a 3 x 3 Latin square experiment. Treatments were a 4-d abomasal infusion of 1) ethanol (control), 2) a trans-10, cis-12 CLA supplement (positive control), and 3) a trans-10, trans-12 CLA supplement; 5 g/d of the CLA isomer of interest was provided. Milk yield, dry matter intake, and milk protein were unaffected by treatment. Treatment with trans-10, trans-12 CLA had no effect on milk fat yield, whereas treatment with trans-10, cis-12 CLA reduced milk fat yield by 28%. Incorporation of CLA was greatest for the plasma triglyceride fraction, and the milk fat content was subsequently elevated within the respective treatment groups. The milk fatty acid composition indicated that δ9-desaturase was reduced significantly for both CLA treatments, but the reduction was greater for the treatment with trans-10, trans-12 CLA. Overall, abomasal infusion of trans-10, trans-12 CLA and trans-10, cis-12 CLA altered the desaturase ratios, but only trans-10, cis-12 CLA reduced milk fat synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dairy Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fatty acids
KW - Cows
KW - Linoleic acid
KW - Milkfat
KW - Milk yield
KW - conjugated linoleic acid
KW - desaturase
KW - lactation
KW - milk fat
N1 - Accession Number: 21647825; Perfield II, J. W. 1; Delmonte, P. 2; Lock, A. L. 1; Yurawecz, M. P. 2; Bauman, D. E. 1; Email Address: deb6@cornell.edu; Affiliations: 1: Department of Animal Science, Cornell University, Ithaca, NY 1485; 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740; Issue Info: Jul2006, Vol. 89 Issue 7, p2559; Thesaurus Term: Fatty acids; Thesaurus Term: Cows; Subject Term: Linoleic acid; Subject Term: Milkfat; Subject Term: Milk yield; Author-Supplied Keyword: conjugated linoleic acid; Author-Supplied Keyword: desaturase; Author-Supplied Keyword: lactation; Author-Supplied Keyword: milk fat; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112120 Dairy Cattle and Milk Production; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 6 Charts, 1 Graph; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Mark D.
T1 - The Role of Environmental Health Practitioners in a Public Health Emergency.
JO - Journal of Environmental Health
JF - Journal of Environmental Health
Y1 - 2006/07//Jul/Aug2006
VL - 69
IS - 1
M3 - Article
SP - 36
EP - 37
PB - National Environmental Health Association
SN - 00220892
AB - The article presents information related to environmental health practitioners' duties during emergencies in the U.S. Environmental health practitioners must take active part in local and state emergency response planning efforts. They must understand the value of their skills in response to emergency events. Environmental health practitioners need to be flexible. They should apply their skills and knowledge across several areas of environmental health. The basics of environmental health are often needed to be reviewed by practitioners. They address and evaluate a variety of environmental issues. They have the ability to collect, analyze, and translate environmental data in emergencies. The need for environmental health practitioners and resources during emergencies was demonstrated by the environmental health issues that arose during the 2005 hurricane season. During emergencies, environmental health practitioners have essential roles to play.
KW - Environmental health personnel
KW - Emergency management
KW - Environmental engineering
KW - Environmental health
KW - Health risk assessment
KW - Environmental policy
KW - Environmental protection
KW - Public health personnel
KW - United States
N1 - Accession Number: 21646211; Miller, Mark D. 1; Email Address: zdq8@cdc.gov.; Affiliations: 1: U.S. Public Health Service Senior Environmental Health Officer, Environmental Health Services Branch, National Center for Environmental Health, CDC, 4770 Buford Highway, NE, MS F28, Atlanta, GA 30341; Issue Info: Jul/Aug2006, Vol. 69 Issue 1, p36; Thesaurus Term: Environmental health personnel; Thesaurus Term: Emergency management; Thesaurus Term: Environmental engineering; Thesaurus Term: Environmental health; Thesaurus Term: Health risk assessment; Thesaurus Term: Environmental policy; Thesaurus Term: Environmental protection; Subject Term: Public health personnel; Subject: United States; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1029
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kim, H. J.
AU - Park, S. H.
AU - Lee, T. H.
AU - Nahm, B. H.
AU - Chung, Y. H.
AU - Seo, K. H.
AU - Kim, H. V.
T1 - Identification of Salmonella enterica Serovar Typhimurium Using Specific PCR Primers Obtained by Comparative Genomics in Salmonella Serovars.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/07//
VL - 69
IS - 7
M3 - Article
SP - 1653
EP - 1661
SN - 0362028X
AB - Salmonella enterica serovar Typhimurium is a major foodborne pathogen throughout the world. Until now, the specific target genes for the detection and identification of serovar Typhimurium have not been developed. To determine the specific probes for serovar Typhimurium, the genes of serovar Typhimurium LT2 that were expected to be unique were selected with the BLAST (Basic Local Alignment Search Tool) program within GenBank. The selected genes were compared with 11 genomic sequences of various Salmonella serovars by BLAST. Of these selected genes, 10 were expected to be specific to serovar Typhimurium and were not related to virulence factor genes of Salmonella pathogenicity island or to genes of the 0 and H antigens of Salmonella. Primers for the 10 selected genes were constructed, and PCRs were evaluated with various genomic DNAs of Salmonella and non-Salmonella strains for the specific identification of Salmonella serovar Typhimurium. Among all the primer sets for the 10 genes, STM4497 showed the highest degree of specificity to serovar Typhimurium. In this study, a specific primer set for Salmonella serovar Typhimurium was developed on the basis of the comparison of genomic sequences between Salmonella serovars and was validated with PCR. This method of comparative genomics to select target genes or sequences can be applied to the specific detection of microorganisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Antigens
KW - Genomics
KW - DNA
KW - Polymerase chain reaction
N1 - Accession Number: 21633313; Kim, H. J. 1; Park, S. H. 1; Lee, T. H. 2; Nahm, B. H. 2; Chung, Y. H. 3; Seo, K. H. 4; Kim, H. V. 1; Email Address: hykim@khu.ac.kr; Affiliations: 1: Institute of Life Sciences and Resources and Graduate School of Biotechnology, Kyung Hee University, Suwon, 449-701, Korea; 2: Green Gene Bio Tech Inc., Myongji University, Yongin, 449-728, Korea; 3: Korea Consumer Protection Board, Seoul, 137-700, Korea; 4: U.S. Food and Drug Administration, CFSAN/OPDFB, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Jul2006, Vol. 69 Issue 7, p1653; Thesaurus Term: Salmonella; Thesaurus Term: Antigens; Subject Term: Genomics; Subject Term: DNA; Subject Term: Polymerase chain reaction; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pascall, Melvin A.
AU - Ravishankar, Sadhana
AU - Ghiron, Ken
AU - Lee, Bowen T.
AU - Johannessen, Jan N.
T1 - Evaluation of Magnetic Resonance for Detection of Bacterial Contamination in Low-Acid, Shelf-Stable Packaged Soymilk.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/07//
VL - 69
IS - 7
M3 - Article
SP - 1668
EP - 1674
SN - 0362028X
AB - This study evaluated magnetic resonance (MR) as a nondestructive method for detection of bacterial contamination in shelf-stable soymilk and cheese sauce. To accomplish this, individual 355-ml polymeric trays filled with soymilk and inoculated with Bacillus stearothermophilus and Bacillus subtilis (10³ CFU) were incubated for up to 28 h at 55°C and 62 h at 37°C, respectively. MR relaxation times (T2) of these samples were then correlated with the bacterial growth as well as viscosity and pH changes caused by the bacteria in the packaged soymilk. In addition, this study investigated the ability of MR to differentiate between regularly processed cheese sauce and cheese sauce that was modified with α-amylase as a spoilage simulation. Results showed increased MR T2 relaxation times after the bacterial populations reached 108 CFU/ml (after 18 h) and 107 CFU/ml (after 44 h) for B. stearothermophilus and B. subtilis, respectively. B. subtilis had an undetectable influence on viscosity but a profound influence on pH. B. stearothermophilus, in comparison, significantly lowered the pH and increased the viscosity of the soymilk. MR was able to distinguish between regularly processed 85-g pouches of cheese sauce and other pouches with sauce that were modified with 0.5 ml of 1% a-amylase solution. These results showed that MR has the potential to be used for nondestructive detection of physical changes in soymilk and cheese sauce induced by bacterial growth and enzymatic activities, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Bacteria
KW - Hydrogen-ion concentration
KW - Food spoilage
KW - Magnetic resonance
KW - Soymilk
N1 - Accession Number: 21633315; Pascall, Melvin A. 1; Email Address: pascall.l@osu.edu; Ravishankar, Sadhana 2; Ghiron, Ken 3; Lee, Bowen T. 4; Johannessen, Jan N. 4; Affiliations: 1: National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois; 2: National Center for Food Safely and Technology, Illinois Institute of Technology Moffett Campus, 6502 South Archer Road, Summit-Argo, Illinois; 3: 1875 Sherwood Road, Allentown, Pennsylvania; 4: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, Maryland 20708, USA; Issue Info: Jul2006, Vol. 69 Issue 7, p1668; Thesaurus Term: Food contamination; Thesaurus Term: Bacteria; Thesaurus Term: Hydrogen-ion concentration; Thesaurus Term: Food spoilage; Subject Term: Magnetic resonance; Subject Term: Soymilk; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steinberg, Ellen B.
AU - Henderson, Alden
AU - Karpati, Adam
AU - Hoekstra, Mike
AU - Marano, Nina
AU - Martinelli Souza, Jennifer
AU - Simons, Meg
AU - Kruger, Kirby
AU - Giroux, Jennifer
AU - Rogers, Helen S.
AU - Hoffman, Michael K.
AU - Kadry, Abdel-Razak M.
AU - Griffin, Patricia M.
T1 - Mysterious Outbreaks of Gastrointestinal Illness Associated with Burritos Supplied through School Lunch Programs.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/07//
VL - 69
IS - 7
M3 - Article
SP - 1690
EP - 1698
SN - 0362028X
AB - From October 1997 through March 1998, three outbreaks of gastrointestinal illness among school children were linked to company A burritos. In September 1998, a similar outbreak occurred in three North Dakota schools following lunches that included company B burritos. We conducted an investigation to determine the source of the North Dakota outbreak, identify other similar outbreaks, characterize the illness, and gather evidence about the cause. The investigation included epidemiologic analyses, environmental investigation, and laboratory analyses. In North Dakota, a case was defined as nausea, headache, abdominal cramps, vomiting, or diarrhea after lunch on 16 September 1998. Case definitions varied in the other states. In North Dakota, 504 students and staff met the case definition; predominant symptoms were nausea (72%), headache (68%), abdominal cramps (54%), vomiting (24%), and diarrhea (16%). The median incubation period was 35 mm and median duration of illness was 6 h. Eating burritos was significantly associated with illness (odds ratio, 2.6; 95% confidence interval, 1.6 to 4.2). We identified 16 outbreaks that occurred in seven states from October 1997 through October 1998, affecting more than 1,900 people who ate burritos from two unrelated companies. All tortillas were made with wheat flour, but the fillings differed, suggesting that tortillas contained the etiologic agent. Results of plant inspections, tracebacks, and laboratory investigations were unrevealing. More than two million pounds of burritos were recalled or held from distribution. The short incubation period, symptoms, and laboratory data suggest that these outbreaks were caused by an undetected toxin or an agent not previously associated with this clinical syndrome. Mass psychogenic illness is an unlikely explanation because of the large number of sites where outbreaks occurred over a short period, the similarity of symptoms, the common food item, the lack of publicity, and the link to only two companies. A network of laboratories that can rapidly identify known and screen for unknown agents in food is a critical part of protecting the food supply against natural and intentional contamination. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gastrointestinal diseases
KW - Burritos (Cooking)
KW - Stuffed foods (Cooking)
KW - National school lunch program
KW - North Dakota
N1 - Accession Number: 21633318; Steinberg, Ellen B. 1,2; Email Address: ellen.stevenson@choa.org; Henderson, Alden 3; Karpati, Adam 2,3; Hoekstra, Mike 1; Marano, Nina 1; Martinelli Souza, Jennifer 4; Simons, Meg 5; Kruger, Kirby 6; Giroux, Jennifer 1,7; Rogers, Helen S. 3; Hoffman, Michael K. 8; Kadry, Abdel-Razak M. 8; Griffin, Patricia M. 1; Affiliations: 1: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases; 2: Epidemic Intelligence Service, Epidemiology Program Office; 3: Health Studies Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia; 4: Boston University Medical Center, 715 Albany Street, Boston, Massachusetts; 5: Indian Health Service, P.O. Box 160, Be/court, North Dakota; 6: North Dakota Department of Health, 600 East Boulevard Avenue, Bismark, North Dakota; 7: Indian Health Service, 5300 Homestead Road N.E., Albuquerque, New Mexico; 8: U.S. Department of Agriculture, Food Safety and Inspection Service, Aerospace Center, Room 334, 901 D Street S. W., Washington, D.C. 20024, USA; Issue Info: Jul2006, Vol. 69 Issue 7, p1690; Subject Term: Gastrointestinal diseases; Subject Term: Burritos (Cooking); Subject Term: Stuffed foods (Cooking); Subject Term: National school lunch program; Subject: North Dakota; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jackson, David S.
AU - Crockett, David F.
AU - Wolnik, Karen A.
T1 - The Indirect Detection of Bleach (Sodium Hypochlorite) in Beverages as Evidence of Product Tampering.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2006/07//
VL - 51
IS - 4
M3 - Article
SP - 827
EP - 831
SN - 00221198
AB - Bleach (sodium hypochlorite) has been identified as the adulterant in a relatively large number of product tamperings that have been investigated by the Forensic Chemistry Center (FCC) of the U.S. Food and Drug Administration. In this work, household bleach was added to 23 different beverages at each of three levels. The impact of sodium hypochlorite on these beverages over a 13-day study period was evaluated using the following techniques: diphenylamine spot test for oxidizing agents, potassium iodide-starch test paper for oxidizing agents, pH, iodometric titration for quantitating hypochlorite, ion chromatography for chloride and chlorate quantitation, automated headspace sampling with gas chromatography–flame ionization detection (GC–FID) for determination of chloroform, and visual and organoleptic observations. This study has shown that hypochlorite is fragile when added to most common beverages and typically breaks down either partially or completely over time. In cases where a beverage is suspected of being adulterated with bleach but tests for hypochlorite are negative, it is still possible to characterize the product to demonstrate that the results are consistent with the addition of bleach. An adulterated product will give a positive test for oxidizing agents using the diphenylamine spot test. It is likely that the pH of the adulterated product will be higher than a control of that product. Ion chromatographic analysis shows elevated chloride and chlorate as compared with a control. And, chloroform may also be detected by GC–FID especially if the beverage that was adulterated contains citric acid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Forensic Sciences (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SODIUM hypochlorite
KW - PRODUCT tampering
KW - FORENSIC chemistry
KW - FOOD -- Sensory evaluation
KW - UNITED States
KW - adulteration
KW - bleach
KW - forensic science
KW - ion chromatography
KW - product tampering
KW - sodium hypochlorite
KW - suppressed conductivity
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 21437548; Jackson, David S. 1; Email Address: david.jackson@fda.hhs.gov Crockett, David F. 1 Wolnik, Karen A. 1; Affiliation: 1: Forensic Chemistry Center, U.S. Food and Drug Administration, Cincinnati, OH, 45237.; Source Info: Jul2006, Vol. 51 Issue 4, p827; Subject Term: SODIUM hypochlorite; Subject Term: PRODUCT tampering; Subject Term: FORENSIC chemistry; Subject Term: FOOD -- Sensory evaluation; Subject Term: UNITED States; Author-Supplied Keyword: adulteration; Author-Supplied Keyword: bleach; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: ion chromatography; Author-Supplied Keyword: product tampering; Author-Supplied Keyword: sodium hypochlorite; Author-Supplied Keyword: suppressed conductivity; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1556-4029.2006.00160.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuan, Liming
T1 - Ignition of hydraulic fluid sprays by open flames and hot surfaces
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2006/07//
VL - 19
IS - 4
M3 - Article
SP - 353
EP - 361
SN - 09504230
AB - Abstract: A study of the ignition of non-fire-resistant hydraulic fluid sprays was conducted by the National Institute for Occupational Safety and Health. Both an open flame and a hot steel surface were used as the external heat sources. With the open flame as the heat source, the minimum oil temperature and minimum spray nozzle pressure that resulted in an ignition were measured. The effects of the distance between the open flame and the nozzle and the nozzle orifice diameter on the ignitability of the hydraulic fluid sprays were examined. With the hot surface as the heat source, the minimum surface ignition temperature was determined. The degree of oil atomization and the relative direction of oil injection with respect to the hot surface are discussed. The ignition of oil sprays from the impingement of oil jets onto a vertical surface was also investigated. Finally, the results are compared with those obtained for fire-resistant hydraulic fluids. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL safety
KW - HYDRAULIC fluids
KW - GAS appliances -- Ignition
KW - SPRAY nozzles
KW - Hot surface
KW - Hydraulic fluid
KW - Ignition
KW - Open flame
N1 - Accession Number: 19395156; Yuan, Liming 1; Email Address: lcy6@cdc.gov; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Jul2006, Vol. 19 Issue 4, p353; Thesaurus Term: INDUSTRIAL safety; Subject Term: HYDRAULIC fluids; Subject Term: GAS appliances -- Ignition; Subject Term: SPRAY nozzles; Author-Supplied Keyword: Hot surface; Author-Supplied Keyword: Hydraulic fluid; Author-Supplied Keyword: Ignition; Author-Supplied Keyword: Open flame; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jlp.2005.09.001
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106324606
T1 - Translating research into evidence-based nursing practice and evaluating effectiveness.
AU - Coopey M
AU - Nix MP
AU - Clancy CM
Y1 - 2006/07//Jul-Sep2006
N1 - Accession Number: 106324606. Language: English. Entry Date: 20060825. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Nursing Practice, Evidence-Based
KW - Research, Nursing
KW - Nursing Organizations
KW - Outcomes (Health Care)
KW - Patient Safety
KW - Practice Guidelines
KW - Quality Improvement
KW - Systematic Review
SP - 195
EP - 202
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 21
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Rd, Suite 6000, Rockville, MD 20850; Salina.Prasad@ahrq.hhs.gov
U2 - PMID: 16816597.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cunningham, Christina
AU - Johnson, Shannah
AU - Cowell, Brandy
AU - Soroudi, Nafisseh
AU - Isaacson, Segal
AU - Davis, Nicholas
AU - lsasi, Carmen R.
AU - Wylie-Rosett, Judith
T1 - Menu Plans in a Diabetes Self-management Weight Loss Program.
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
Y1 - 2006/07//Jul/Aug2006
VL - 38
IS - 4
M3 - Article
SP - 264
EP - 266
SN - 14994046
AB - The article looks at a study that examined menu plans for a diabetes self-management weight loss program. In the study participants were given a menu plan and a grocery list in an attempt to simplify decision making, develop self-efficacy, offer support during the transition to new eating habits, and decrease impulse food purchases. During the study a registered dietitian met with each participant to alter the menu plan and grocery list based on food preferences and needs. According to the article, meal planning is an effective approach to diabetes management and weight control.
KW - DIABETICS
KW - RESEARCH
KW - SELF-management (Psychology)
KW - DECISION making
KW - MENU design (Printed ephemera)
KW - BODY weight -- Regulation
KW - WEIGHT loss
KW - FOOD preferences
KW - FOOD habits
KW - HEALTH behavior -- Research
KW - NUTRITION research
KW - GROCERY shopping
N1 - Accession Number: 22606870; Cunningham, Christina 1 Johnson, Shannah 2 Cowell, Brandy 3 Soroudi, Nafisseh 4 Isaacson, Segal 5 Davis, Nicholas 6 lsasi, Carmen R. 5 Wylie-Rosett, Judith 7; Email Address: jwrosett@aecom.yu.edu; Affiliation: 1: Nutritionist, Beth Abrahams Hospital 2: Research Fellow, Indian Health Service 3: Research Nutritionist, Albert Einstein College of Medicine, Bronx, NY 4: Postdoctoral Fellow in Psychiatry, Massachusetts General Hospital C.J. 5: Assistant Professor of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 6: Assistant Professor of Medicine, Albert Einstein College of Medicine, Bronx, NY 7: Professor of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; Source Info: Jul/Aug2006, Vol. 38 Issue 4, p264; Subject Term: DIABETICS; Subject Term: RESEARCH; Subject Term: SELF-management (Psychology); Subject Term: DECISION making; Subject Term: MENU design (Printed ephemera); Subject Term: BODY weight -- Regulation; Subject Term: WEIGHT loss; Subject Term: FOOD preferences; Subject Term: FOOD habits; Subject Term: HEALTH behavior -- Research; Subject Term: NUTRITION research; Subject Term: GROCERY shopping; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Law, Brandon F.
AU - Stone, Samuel
AU - Frazer, David
AU - Siegel, Paul D.
T1 - Characterization of Laboratory Simulated Road Paving-Like Asphalt by High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/07//
VL - 3
IS - 7
M3 - Article
SP - 343
EP - 350
PB - Taylor & Francis Ltd
SN - 15459624
AB - Prolonged, extensive exposure to asphalt fume has been associated with several adverse health effects. Inhaled polycyclic aromatic hydrocarbons (PAHs) from asphalt fume exposure are of concern. The objective of this study was to characterize both qualitative and quantitative differences between fumes generated at 150°C and 180°C using a well-controlled laboratory road paving fume generation system. Fumes were characterized by total volatile and particulate concentration, simulated boiling point profile, and specific PAH content. The mean concentrations of the volatile fractions generated at 180°C and 150°C were 23.3 mg/m3 and 11.2 mg/m3, respectively, demonstrating a statistically significant shift in concentration. The mean concentrations of the particulate fractions generated at 180°C and 150°C were 42.4 mg/m3 and 28.0 mg/m3, respectively. The simulated boiling point profile did not show a significant qualitative difference between the fumes generated at the two temperatures. Naphthalene, acenaphthene, fluorene, phenanthrene, fluoranthene, pyrene, and chrysene were identified and quantified from the fumes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt
KW - Liquid chromatography
KW - Gas chromatography
KW - Mass spectrometry
KW - Aromatic compounds
KW - asphalt
KW - bitumen
KW - characterization
KW - fume
KW - GC/MS
N1 - Accession Number: 75127697; Law, Brandon F. 1; Stone, Samuel 1; Frazer, David 1; Siegel, Paul D. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Jul2006, Vol. 3 Issue 7, p343; Thesaurus Term: Asphalt; Thesaurus Term: Liquid chromatography; Thesaurus Term: Gas chromatography; Thesaurus Term: Mass spectrometry; Thesaurus Term: Aromatic compounds; Author-Supplied Keyword: asphalt; Author-Supplied Keyword: bitumen; Author-Supplied Keyword: characterization; Author-Supplied Keyword: fume; Author-Supplied Keyword: GC/MS; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620600732795
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Heitbrink, William
AU - Bennett, James
T1 - A Numerical and Experimental Investigation of Crystalline Silica Exposure Control During Tuck Pointing.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/07//
VL - 3
IS - 7
M3 - Article
SP - 366
EP - 378
PB - Taylor & Francis Ltd
SN - 15459624
AB - National Institute for Occupational Safety and Health researchers investigated control measures for the removal of mortar between bricks, using a grinder. This task, 'tuck pointing,' is associated with crystalline silica exposures many times greater than the permissible exposure limit enforced by the Occupational Safety and Health Administration. Previous studies showed that local exhaust ventilation (LEV) of the grinding wheel through a shroud was often ineffective. Tuck pointing occurs on a scaffold. For practical purposes, this limits the size and power of the LEV system. Thus, the goal of this study was to develop a recommended flow rate for exposure control. Flow induced by the rotating grinding wheel, flow induced by the mortar particle stream, and particle momentum are potential control challenges. Computational fluid dynamic (CFD) simulation of the grinder, supported by some experimental measurements, showed the relative importance of these factors through varying parameters and tracking particles. In a simulation of the shroud and grinding wheel, with the wheel inserted to a cutting depth of 0.750 inch flush into the brick wall, -0.461 cubic feet per meter (0.461 into the exhaust takeoff) was induced by the rotating wheel. The more realistic situation of the wheel in a cut in the wall 1.25 inches deep (forming a trench circumferentially 0.500 inch below the wheel edge) induced an airflow of 8.24 cfm out of the shroud exhaust. Experimental measurements taken for validation were 7.3% lower than the CFD value. The trench effect disappeared when a stream of 10-μ m particles was launched from the grinding wheel edge, as the simulations with and without the trench had nearly identical induced flow rates, 10.8 cfm and 10.9 cfm. We thus interpreted the particle stream as more important than the wheel in inducing flow. This insight was possible because of the power of CFD, compared to intuition and classical boundary layer analysis. In this situation of no forced exhaust, all particles escaped through the gap between the shroud edge and the brick wall into the worker's environment. Experiments and simulations indicated that approximately 85 cfm was required for good control of silica exposure, clearly demonstrating that the exhaust rate must accomplish much more than balancing the induced flow. The simulations showed that the exhaust must create a vacuum in the shroud sufficient to bend the particle paths into the shroud. In the simulations, stopping the particle stream through collision (effectively removing or reducing the 'daylight' between the wall and shroud) greatly lessened the required flow rate. This is difficult in practice because the gaps between the shroud and the brick and between bricks create escape paths. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Silica
KW - Mortar
KW - United States
KW - CFD
KW - silica
KW - tuck pointing
KW - ventilation
KW - United States. Occupational Safety & Health Administration
N1 - Accession Number: 75127694; Heitbrink, William 1; Bennett, James 2; Affiliations: 1: Environmental Health Sciences, University of Iowa, Iowa City, Iowa; 2: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Enginnering and Physical Hazards Branch, Cincinnati, Ohio; Issue Info: Jul2006, Vol. 3 Issue 7, p366; Thesaurus Term: Industrial safety; Subject Term: Silica; Subject Term: Mortar; Subject: United States; Author-Supplied Keyword: CFD; Author-Supplied Keyword: silica; Author-Supplied Keyword: tuck pointing; Author-Supplied Keyword: ventilation ; Company/Entity: United States. Occupational Safety & Health Administration; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 13p; Illustrations: 4 Black and White Photographs, 3 Diagrams, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620600762057
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pendergrass, Stephanie M.
AU - Ernst, Jennifer L.
AU - Dollberg, Donald D.
T1 - NMAM Methods Update: A Laboratory Response to Concerns About Technologically Outdated and Problematic Methods.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/07//
VL - 3
IS - 7
M3 - Article
SP - 390
EP - 396
PB - Taylor & Francis Ltd
SN - 15459624
AB - The National Institute for Occupational Safety Health (NIOSH) publishes the NIOSH Manual of Analytical Methods (NMAM). The NMAM, although subject to various revisions and the incorporation of supplemental editions over the years, still contains many methods that are technologically outdated or problematic, as identified in a recent survey of the various users of the NMAM. Whereas the survey identified a number of problematic methods based on various chromatographic techniques, those selected for inclusion in this project employed analysis by gas chromatography (GC). The GC methods selected for evaluation were categorized as Phases 1, 2, 3, and 4 based on necessity as determined by the results of the client survey or internal assessment. The Phase 1 methods included: NMAM 1606 (Acetonitrile), NMAM 2005 (Nitroaromatic Compounds), and NMAM 1453 (Vinyl Acetate); the Phase 2 methods: NMAM 1003 (Halogenated Hydrocarbons), NMAM 1501 (Aromatic Hydrocarbons), NMAM 2555 (Ketones I), and NMAM 1403 (Alcohols IV); the Phase 3 methods: NMAM 2552 (Methyl Acrylate), NMAM 2537 (Methyl and Ethyl Methacrylate), and NMAM 2553 (Ketones II), and the Phase 4 methods: NMAM 2556 (Isophorone), NMAM 1460 (Isopropyl Acetate), and NMAM 1618 (Isopropyl Ether). All methods previously specifying packed column chromatography have been evaluated using the appropriate fused silica capillary column. Improvements in individual analyte desorption efficiencies were achieved at concentrations substantially lower than those used in the previous methods. Most analytes evaluated had their respective limit of detection lowered by a factor of ten-to twentyfold. Thirty-day storage stability studies, previously lacking in a number of methods or for new analytes, were successfully completed to meet current method development criteria. Additional benefits resulting from this effort included the incorporation of single analyte methods into chemically related multianalyte methods and the evaluation of certain isomers, such as the methylstyrenes and xylenes, which previously could not be separated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Industrial safety
KW - Vinyl acetate
KW - Halocarbons
KW - Nitroaromatic compounds
KW - gas chromatography
KW - NIOSH
KW - NMAM
N1 - Accession Number: 75127692; Pendergrass, Stephanie M. 1; Ernst, Jennifer L. 1; Dollberg, Donald D. 1; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jul2006, Vol. 3 Issue 7, p390; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Industrial safety; Thesaurus Term: Vinyl acetate; Thesaurus Term: Halocarbons; Subject Term: Nitroaromatic compounds; Author-Supplied Keyword: gas chromatography; Author-Supplied Keyword: NIOSH; Author-Supplied Keyword: NMAM; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/10543400600760446
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106329865
T1 - Characterization of laboratory simulated road paving-like asphalt by high-performance liquid chromatography and gas chromatography-mass spectrometry.
AU - Law BF
AU - Stone S
AU - Frazer D
AU - Siegel PD
Y1 - 2006/07//
N1 - Accession Number: 106329865. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Note: For CE see Suppl pages D71-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Funded in part by an interagency agreement with the National Institute of Environmental Health Sciences and the National Toxicology Program. NLM UID: 101189458.
KW - Construction Materials -- Evaluation
KW - Occupational Exposure
KW - Spectrometry, Fluorescence
KW - Aerosols
KW - Data Analysis Software
KW - Industry
KW - Occupational Hazards
KW - Particulate Matter
KW - Regression
KW - T-Tests
KW - Funding Source
KW - Human
SP - 343
EP - 350
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Prolonged, extensive exposure to asphalt fume has been associated with several adverse health effects. Inhaled polycyclic aromatic hydrocarbons (PAHs) from asphalt fume exposure are of concern. The objective of this study was to characterize both qualitative and quantitative differences between fumes generated at 150 degrees C and 180 degrees C using a well-controlled laboratory road paving fume generation system. Fumes were characterized by total volatile and particulate concentration, simulated boiling point profile, and specific PAH content. The mean concentrations of the volatile fractions generated at 180 degrees C and 150 degrees C were 23.3 mg/m3 and 11.2 mg/m3, respectively, demonstrating a statistically significant shift in concentration. The mean concentrations of the particulate fractions generated at 180 degrees C and 150 degrees C were 42.4 mg/m3 and 28.0 mg/m3, respectively. The simulated boiling point profile did not show a significant qualitative difference between the fumes generated at the two temperatures. Naphthalene, acenaphthene, fluorene, phenanthrene, fluoranthene, pyrene, and chrysene were identified and quantified from the fumes.
SN - 1545-9624
AD - Allergy and Clinical Immunology Branch, MS L4020 Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888; bhl7@cdc.gov
U2 - PMID: 16835160.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106329887
T1 - NMAM methods update: a laboratory response to concerns about technologically outdated and problematic methods...NIOSH Manual of Analytical Methods
AU - Pendergrass SM
AU - Ernst JL
AU - Dollberg DD
Y1 - 2006/07//
N1 - Accession Number: 106329887. Language: English. Entry Date: 20060908. Revision Date: 20150711. Publication Type: Journal Article; CEU; research; tables/charts. Note: For CE see Suppl pages D71-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Chromatography, Gas -- Methods
KW - National Institute for Occupational Safety and Health
KW - Occupational Health
KW - Occupational Safety
KW - Practice Guidelines
KW - Education, Continuing (Credit)
KW - Measurement Issues and Assessments
KW - Research Methodology
KW - United States
KW - Human
SP - 390
EP - 396
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety Health (NIOSH) publishes the NIOSH Manual of Analytical Methods (NMAM). The NMAM, although subject to various revisions and the incorporation of supplemental editions over the years, still contains many methods that are technologically outdated or problematic, as identified in a recent survey of the various users of the NMAM. Whereas the survey identified a number of problematic methods based on various chromatographic techniques, those selected for inclusion in this project employed analysis by gas chromatography (GC). The GC methods selected for evaluation were categorized as Phases 1, 2, 3, and 4 based on necessity as determined by the results of the client survey or internal assessment. The Phase 1 methods included: NMAM 1606 (Acetonitrile), NMAM 2005 (Nitroaromatic Compounds), and NMAM 1453 (Vinyl Acetate); the Phase 2 methods: NMAM 1003 (Halogenated Hydrocarbons), NMAM 1501 (Aromatic Hydrocarbons), NMAM 2555 (Ketones I), and NMAM 1403 (Alcohols IV); the Phase 3 methods: NMAM 2552 (Methyl Acrylate), NMAM 2537 (Methyl and Ethyl Methacrylate), and NMAM 2553 (Ketones II), and the Phase 4 methods: NMAM 2556 (Isophorone), NMAM 1460 (Isopropyl Acetate), and NMAM 1618 (Isopropyl Ether).All methods previously specifying packed column chromatography have been evaluated using the appropriate fused silica capillary column. Improvements in individual analyte desorption efficiencies were achieved at concentrations substantially lower than those used in the previous methods. Most analytes evaluated had their respective limit of detection lowered by a factor of ten-to twentyfold. Thirty-day storage stability studies, previously lacking in a number of methods or for new analytes, were successfully completed to meet current method development criteria. Additional benefits resulting from this effort included the incorporation of single analyte methods into chemically related multianalyte methods and the evaluation of certain isomers, such as the methylstyrenes and xylenes, which previously could not be separated.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 16835165.
DO - 10.1080/10543400600760446
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106329887&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Robinson, Cynthia F.
AU - Schnorr, Teresa M.
AU - Cassinelli II, Rick T.
AU - Calvert, Geoffrey M.
AU - Steenland, N. Kyle
AU - Gersic, Christine M.
AU - Schubauer-Berigan, Mary K.
T1 - Tenth Revision U.S. Mortality Rates for Use With the NIOSH Life Table Analysis System.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/07//
VL - 48
IS - 7
M3 - Article
SP - 662
EP - 667
SN - 10762752
AB - The article presents a study on the updating of rate files for the National Institute for Occupational Safety and Health (NIOSH) Life Table Analysis System for Personal Computers (PC LTAS), reflecting the newly adapted tenth revision changes to the International Classification of Diseases. The NIOSH (PC LTAS) uses the World Health Organization International Classification of Diseases (ICD) code for the cause of death. The codes are used by the National Center for Health Statistics to code annually all American population deaths for compilation and publication of national and state mortality rates.
KW - MORTALITY -- Statistics
KW - HEALTH risk assessment
KW - DEATH
KW - MEDICINE
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
KW - WORLD Health Organization
KW - NATIONAL Center for Health Statistics (U.S.)
KW - INTERNATIONAL Statistical Classification of Diseases & Related Health Problems
N1 - Accession Number: 21835065; Robinson, Cynthia F. 1; Email Address: cfr2@cdc.gov Schnorr, Teresa M. 1 Cassinelli II, Rick T. 1 Calvert, Geoffrey M. Steenland, N. Kyle 1,2 Gersic, Christine M. 1 Schubauer-Berigan, Mary K. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio 2: Department of Environmental/Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia; Source Info: Jul2006, Vol. 48 Issue 7, p662; Subject Term: MORTALITY -- Statistics; Subject Term: HEALTH risk assessment; Subject Term: DEATH; Subject Term: MEDICINE; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health Company/Entity: WORLD Health Organization Company/Entity: NATIONAL Center for Health Statistics (U.S.); Reviews & Products: INTERNATIONAL Statistical Classification of Diseases & Related Health Problems; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1097/01.jom.0000229968.74906.8f
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Filon, Francesca Larese
AU - Boeniger, Mark
AU - Maina, Giovanni
AU - Adami, Gianpiero
AU - Spinelli, Paolo
AU - Damian, Adriano
T1 - Skin Absorption of Inorganic Lead (PbO) and the Effect of Skin Cleansers.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/07//
VL - 48
IS - 7
M3 - Article
SP - 692
EP - 699
SN - 10762752
AB - The article presents a study which aims to investigate the skin absorption of lead oxide (PbO) powder and the effect of skin decontamination with two different cleansers, the Ivory Liquid Soap, which contains sodium lauryl sulfate, and the NIOSH cleanser, a new experimental detergent. In vitro PbO skin penetration using human skin was measured for a period of 24-hours using Franz cells. It offers the details of the methods used in the experiment and discusses the results, which indicated the need to prevent the occurrence of skin contamination.
KW - DETERGENTS -- Physiological effect
KW - SKIN absorption
KW - LEAD oxides
KW - WASHING powders
KW - CLEANING compounds
KW - CELLS
KW - RESEARCH
KW - SKIN -- Physiology
KW - ABSORPTION (Physiology)
N1 - Accession Number: 21835069; Filon, Francesca Larese 1; Email Address: larese@units.it Boeniger, Mark 2 Maina, Giovanni 3 Adami, Gianpiero 4 Spinelli, Paolo 3 Damian, Adriano 1; Affiliation: 1: Unità Clinico Operativa di Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Università di Trieste, Trieste, Italy 2: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 3: UOADU Servizio di Tossicologia ed Epidemiologia Industriale, Dipartimento di Traumatologia e Medicina del Lavoro, Università, di Torino, Torino, Italy 4: Dipartimento di Chimica (Mr Adami), Università di Trieste, Trieste, Italy; Source Info: Jul2006, Vol. 48 Issue 7, p692; Subject Term: DETERGENTS -- Physiological effect; Subject Term: SKIN absorption; Subject Term: LEAD oxides; Subject Term: WASHING powders; Subject Term: CLEANING compounds; Subject Term: CELLS; Subject Term: RESEARCH; Subject Term: SKIN -- Physiology; Subject Term: ABSORPTION (Physiology); NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1097/01.jom.0000214474.61563.1c
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lyon, Robbe C.
AU - Taylor, Jeb S.
AU - Porter, Donna A.
AU - Prasanna, Hullahalli R.
AU - Hussain, Ajaz S.
T1 - Stability profiles of drug products extended beyond labeled expiration dates.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/07//
VL - 95
IS - 7
M3 - Article
SP - 1549
EP - 1560
SN - 00223549
AB - The American Medical Association has questioned whether expiration dating markedly underestimates the actual shelf life of drug products. Results from the shelf life extension program (SLEP) have been evaluated to provide extensive data to address this issue. The SLEP has been administered by the Food and Drug Administration for the United States Department of Defense (DOD) for 20 years. This program probably contains the most extensive source of pharmaceutical stability data extant. This report summarizes extended stability profiles for 122 different drug products (3005 different lots). The drug products were categorized into five groups based on incidence of initial extension failures and termination failures (extended lot eventually failed upon re-testing). Based on testing and stability assessment, 88% of the lots were extended at least 1 year beyond their original expiration date for an average extension of 66 months, but the additional stability period was highly variable. The SLEP data supports the assertion that many drug products, if properly stored, can be extended past the expiration date. Due to the lot-to-lot variability, the stability and quality of extended drug products can only be assured by periodic testing and systematic evaluation of each lot. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1549–1560, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG stability
KW - CLINICAL drug trials
KW - PHARMACEUTICAL chemistry
KW - PHARMACOLOGY
KW - drug stability
KW - expiration date
KW - shelf life
KW - shelf life extension program
KW - SLEP
KW - AMERICAN Medical Association
N1 - Accession Number: 22171023; Lyon, Robbe C. 1; Email Address: robbe.lyon@fda.hhs.gov Taylor, Jeb S. 1 Porter, Donna A. 2 Prasanna, Hullahalli R. 1 Hussain, Ajaz S. 3; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, HFD-941, White Oak, Life Sciences Building 64, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993-0002 2: Division of Field Science, Office of Regional Operations, Office of Regulatory Affairs, Food and Drug Administration, Rockville, Maryland 20857 3: Vice President & Global Head of Biopharmaceutical Development, Sandoz, 506 Carnegie Center, Princeton, New Jersey 08540; Source Info: Jul2006, Vol. 95 Issue 7, p1549; Subject Term: DRUG stability; Subject Term: CLINICAL drug trials; Subject Term: PHARMACEUTICAL chemistry; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: drug stability; Author-Supplied Keyword: expiration date; Author-Supplied Keyword: shelf life; Author-Supplied Keyword: shelf life extension program; Author-Supplied Keyword: SLEP; Company/Entity: AMERICAN Medical Association DUNS Number: 805631447; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1002/jps.20636
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zongming Gao
AU - Moore, Terry W.
AU - Doub, William H.
AU - Westenberger, B.J.
AU - Buhse, Lucinda F.
T1 - Effects of deaeration methods on dissolution testing in aqueous media: A study using a total dissolved gas pressure meter.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/07//
VL - 95
IS - 7
M3 - Article
SP - 1606
EP - 1613
SN - 00223549
AB - Dissolution testing is a critical method for the determination of pharmaceutical product quality and bioequivalence. For some products, dissolved gases in the dissolution medium affect dissolution results thus requiring degassing of the medium prior to use. In this study, we use a total dissolved gas and oxygen meter to measure both oxygen and total gases in dissolution media before and after application of a variety of deaeration methods. Dissolution testing results using a 10 mg Prednisone tablet (NCDA #2) are compared with the percent saturation of oxygen and total gases found in the medium. Reaeration of the medium during different stirring rates was also measured. This study confirms that measurement of total gases and not just oxygen in the medium is necessary to assess adequacy for dissolution testing. For those deaeration techniques that are performed at room temperature, the percent saturation of the total dissolved gases must be well below 100% to prevent outgassing once medium is brought to dissolution test method temperature, typically 37°C. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1606–1613, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Solubility -- Testing
KW - DRUGS -- Therapeutic equivalency
KW - CLINICAL drug trials
KW - DRUGS
KW - GASES
KW - BIOPHARMACEUTICS
KW - deaeration
KW - degassing
KW - dissolution
KW - dissolved gases
KW - total dissolved gas pressure meter
N1 - Accession Number: 22171029; Zongming Gao 1; Email Address: gaoz@cder.fda.gov Moore, Terry W. 1 Doub, William H. 1 Westenberger, B.J. 1 Buhse, Lucinda F. 1; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri; Source Info: Jul2006, Vol. 95 Issue 7, p1606; Subject Term: DRUGS -- Solubility -- Testing; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: CLINICAL drug trials; Subject Term: DRUGS; Subject Term: GASES; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: deaeration; Author-Supplied Keyword: degassing; Author-Supplied Keyword: dissolution; Author-Supplied Keyword: dissolved gases; Author-Supplied Keyword: total dissolved gas pressure meter; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1002/jps.20622
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106252761
T1 - Revisiting public health preparedness: incorporating social justice principles into pandemic preparedness planning for influenza.
AU - Kayman H
AU - Ablorh-Odjidja A
Y1 - 2006/07//Jul/Aug2006
N1 - Accession Number: 106252761. Language: English. Entry Date: 20070316. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Health and Welfare Planning
KW - Influenza -- Prevention and Control
KW - Public Health Administration
KW - Social Justice
KW - Collaboration
KW - Health Resource Allocation
KW - Immunization Programs
KW - Immunization Programs -- Ethical Issues
KW - Public Health -- Trends
KW - Socioeconomic Factors
SP - 373
EP - 380
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 12
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Public health professionals are responsible for ensuring the health of the nation, which requires that planners for public health emergencies recognize that not including protection for underserved or marginalized communities poses a risk to the entire population. To assure the protection of these populations in the event of a pandemic outbreak, preparedness planning will benefit from the application of several principles of social justice in assuring the protection of all individuals. This article will review the history between public health and social justice, provide a brief review of pandemic preparedness planning efforts, discuss the importance of and make recommendations for the incorporation of principles of social justice in the development of pandemic preparedness plans, and highlight some of the challenges faced by public health in effectively and equitably meeting its charge to protect the nation's health.
SN - 1078-4659
AD - Director, Maternal and Child Health, Bureau, South Carolina Department of Health and Environmental Control
U2 - PMID: 16775535.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dong, R.G.
AU - Welcome, D.E.
AU - McDowell, T.W.
AU - Wu, J.Z.
T1 - Measurement of biodynamic response of human hand–arm system
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2006/07//
VL - 294
IS - 4/5
M3 - Article
SP - 807
EP - 827
SN - 0022460X
AB - Abstract: Biodynamics of the human hand–arm system is one of the most important foundations for understanding hand-transmitted vibration exposure and its health effects. Considerable differences among the reported data of the biodynamic response (BR) of the hand–arm system have been observed. A significant portion of the differences are believed to have resulted from instrumentation problems and/or computational algorithm errors. To help establish a reliable and accurate methodology for BR measurement, this study addresses the fundamental instrumentation issues. Specifically, the general theory of the driving-point BR is reviewed and summarized. An accurate mass cancellation method for BR measurement is identified and further developed. A set of methods is proposed to systematically examine and calibrate the BR measurement system. Based on the experimental results and theoretical analyses, several instrumentation and algorithm problems are identified. This study demonstrated that the instrumentation problems can be resolved or avoided by appropriately selecting the force and motion sensors, improving the structure design of the instrumented handle and fixture, using the frequency-domain method for the handle mass cancellation, and conducting the static and dynamic calibrations of the measurement system using the proposed methods. The information and knowledge presented in this paper can help to generate reliable experimental data in further BR studies. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALGORITHMS
KW - PHYSICAL measurements
KW - STANDARDIZATION
KW - DIMENSIONAL analysis
KW - hand‐arm response
N1 - Accession Number: 20901216; Dong, R.G.; Email Address: rkd6@cdc.gov Welcome, D.E. 1 McDowell, T.W. 1 Wu, J.Z. 1; Affiliation: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, West Virginia 26505, USA; Source Info: Jul2006, Vol. 294 Issue 4/5, p807; Subject Term: ALGORITHMS; Subject Term: PHYSICAL measurements; Subject Term: STANDARDIZATION; Subject Term: DIMENSIONAL analysis; Author-Supplied Keyword: hand‐arm response; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.jsv.2005.12.047
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Carmona, Richard H.
T1 - Make Summer Family Health History Season
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/07//
VL - 106
IS - 7
M3 - Editorial
SP - 1009
EP - 1009
SN - 00028223
N1 - Accession Number: 21429873; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Jul2006, Vol. 106 Issue 7, p1009; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2006.05.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106348565
T1 - From the Surgeon General. Make summer family health history season.
AU - Carmona RH
Y1 - 2006/07//
N1 - Accession Number: 106348565. Language: English. Entry Date: 20061020. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Family Health
KW - Family History
KW - Hereditary Diseases
KW - Information Resources
KW - United States Department of Health and Human Services
KW - World Wide Web
SP - 1009
EP - 1009
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 7
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106186052
T1 - Fresh whole blood transfusion: a controversial military practice.
AU - Kauvar DS
AU - Holcomb JB
AU - Norris GC
AU - Hess JR
Y1 - 2006/07//
N1 - Accession Number: 106186052. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376373.
KW - Blood Coagulation Disorders -- Therapy
KW - Blood Transfusion -- Methods
KW - Military Personnel
KW - Wounds and Injuries -- Complications
KW - Blood Coagulation Disorders -- Etiology
KW - Iraq
KW - Retrospective Design
KW - Safety
KW - Survival Analysis
KW - Treatment Outcomes
KW - United States
KW - Human
SP - 181
EP - 184
JO - Journal of Trauma
JF - Journal of Trauma
JA - J TRAUMA
VL - 61
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0022-5282
AD - From the US Army Institute of Surgical Research (D.S.K., J.B.H.), Fort Sam Houston, Texas; the US Army Blood Program (G.N.), Office of the Surgeon General, Falls Church, Virginia; and the University of Maryland Medical Center (J.R.H.), Baltimore, Maryland.
U2 - PMID: 16832268.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pal, Achintya
AU - Sirota, Lev
AU - Maudru, Thomas
AU - Peden, Keith
AU - Lewis, Andrew M.
T1 - Real-time, quantitative PCR assays for the detection of virus-specific DNA in samples with mixed populations of polyomaviruses
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/07//
VL - 135
IS - 1
M3 - Article
SP - 32
EP - 42
SN - 01660934
AB - Abstract: Mixtures of polyomaviruses can be present in the central nervous system, the gastrointestinal tract, the genitourinary tract, blood, and urban sewage. We have developed 12 primer/probe sets (four per virus) for real-time, quantitative PCR assays (TaqMan) that can specifically detect BKV, JCV, and SV40 genomes present in mixtures of these viruses. The specificities of these primer/probe sets were determined by evaluating their level of interaction with the DNA from other polyomaviruses and their ability to estimate the number of copies of homologous viral DNA in blinded samples of defined mixtures of three polyomaviral DNAs. Three early region and three late region primer/probe sets determined, within a two-fold range, the number of copies of their respective DNAs. Four sets of SV40 primer/probes also detected 1.1–2.4 copies of SV40 DNA per COS-1 cell, cells estimated to contain a single copy of SV40 DNA. Three JCV primer/probe sets detected 3.7–4.2 copies per cell of JCV DNA in the JCV-transformed cell line M1-HR, cells estimated to contain between 0.5 and 1 copy of the JCV genome. We suggest that the virus-specific primer/probe sets in this study be considered sufficiently characterized to initiate the quantification of polyomavirus DNA in biological samples. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYOMAVIRUSES
KW - DNA viruses
KW - GENOMES
KW - DNA probes
KW - BKV
KW - JCV
KW - Polyomavirus
KW - Q-PCR
KW - Real-time PCR
KW - SV40
KW - TaqMan
N1 - Accession Number: 20869183; Pal, Achintya 1 Sirota, Lev 2 Maudru, Thomas 1 Peden, Keith 1 Lewis, Andrew M. 1; Email Address: lewisa@cber.fda.gov; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States 2: Division of Biostatistics, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States; Source Info: Jul2006, Vol. 135 Issue 1, p32; Subject Term: POLYOMAVIRUSES; Subject Term: DNA viruses; Subject Term: GENOMES; Subject Term: DNA probes; Author-Supplied Keyword: BKV; Author-Supplied Keyword: JCV; Author-Supplied Keyword: Polyomavirus; Author-Supplied Keyword: Q-PCR; Author-Supplied Keyword: Real-time PCR; Author-Supplied Keyword: SV40; Author-Supplied Keyword: TaqMan; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.01.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takeshita, Fumihiko
AU - Tanaka, Toshiyuki
AU - Matsuda, Tomoko
AU - Tozuka, Miyuki
AU - Kobiyama, Kouji
AU - Saha, Sukumar
AU - Matsui, Kiyohiko
AU - Ishii, Ken J.
AU - Coban, Cevayir
AU - Akira, Shizuo
AU - Ishii, Norihisa
AU - Suzuki, Koichi
AU - Klinman, Dennis M.
AU - Okuda, Kenji
AU - Sasaki, Shin
T1 - Toll-Like Receptor Adaptor Molecules Enhance DNA-Raised Adaptive Immune Responses against Influenza and Tumors through Activation of Innate Immunity.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/07//
VL - 80
IS - 13
M3 - Article
SP - 30
EP - 30
SN - 0022538X
AB - Toll-like receptors (TLRs) recognize microbial components and trigger the signaling cascade that activates the innate and adaptive immunity. TLR adaptor molecules play a central role in this cascade; thus, we hypothesized that overexpression of TLR adaptor molecules could mimic infection without any microbial components. Dual-promoter plasmids that carry an antigen and a TLR adaptor molecule such as the Toll-interleukin-1 receptor domain-containing adaptor-inducing beta interferon (TRIF) or myeloid differentiation factor 88 (MyD88) were constructed and administered to mice to determine if these molecules can act as an adjuvant. A DNA vaccine incorporated with the MyD88 genetic adjuvant enhanced antigen-specific humoral immune responses, whereas that with the TRIF genetic adjuvant enhanced cellular immune responses. Incorporating the TRIF genetic adjuvant in a DNA vaccine targeting the influenza HA antigen or the tumor-associated antigen E7 conferred superior protection. These results indicate that TLR adaptor molecules can bridge innate and adaptive immunity and potentiate the effects of DNA vaccines against virus infection and tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULES
KW - INFECTION
KW - INTERLEUKINS
KW - INTERFERONS
KW - ANTIGENS
KW - VACCINATION
N1 - Accession Number: 21439976; Takeshita, Fumihiko 1; Email Address: takesita@yokohama-cu.ac.jp Tanaka, Toshiyuki 1 Matsuda, Tomoko 1 Tozuka, Miyuki 1 Kobiyama, Kouji 1 Saha, Sukumar 1 Matsui, Kiyohiko 1 Ishii, Ken J. 2 Coban, Cevayir 2 Akira, Shizuo 2 Ishii, Norihisa 3 Suzuki, Koichi 3 Klinman, Dennis M. 4 Okuda, Kenji 1 Sasaki, Shin 1; Affiliation: 1: Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan 2: ERATO, Akira Innate Immunity Program, Japan Science and Technology Agency, Osaka 565-0871, Japan 3: Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189-0002, Japan 4: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Jul2006, Vol. 80 Issue 13, p30; Subject Term: MOLECULES; Subject Term: INFECTION; Subject Term: INTERLEUKINS; Subject Term: INTERFERONS; Subject Term: ANTIGENS; Subject Term: VACCINATION; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.00121-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delogu, Giovanni
AU - Sanguinetti, Maurizio
AU - Pusceddu, Cinzia
AU - Bua, Alessandra
AU - Brennan, Michael J.
AU - Zanetti, Stefania
AU - Fadda, Giovanni
T1 - PE_PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissues.
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2006/07//
VL - 8
IS - 8
M3 - Article
SP - 2061
EP - 2067
SN - 12864579
AB - Abstract: Characterization of PE_PGRS gene expression will help define the role of this protein family in the biology of Mycobacterium tuberculosis. In this report, quantitative real-time RT-PCR (QRT-PCR) was implemented to assess expression of three PE_PGRS genes (rv0746, rv1651c and rv1818c) under different experimental conditions. The three PE_PGRS genes showed a similar expression profile in axenic cultures, with a significant up-regulation occurring at late log and early stationary phases. rv1651c gene expression increased following intracellular growth in bone marrow-derived macrophages but not in type-II human pneumocytes, while rv0746 was induced in both in vitro systems. Following the infection of mice with M. tuberculosis, expression levels of rv1651c and rv0746 normalized to ftsZ and 16S rRNA were highest in the spleen tissue during the chronic stages of murine tuberculosis, with a >20- and >30-fold up-regulation, respectively. Levels of expression remained lower in the lung over the same time period. Expression of the rv1818c gene did not change significantly under different experimental conditions tested. The results of this study indicate that M. tuberculosis can differentially regulate expression of PE_PGRS genes and that genes such as rv0746 and rv1651c are significantly induced while M. tuberculosis persists in host cells and tissues. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Mycobacterial diseases
KW - Bone marrow
KW - Killer cells
KW - Gene expression
KW - bone-marrow derived macrophages ( BMM0 )
KW - colony-forming units ( CFU )
KW - multiplicity of infection ( MOI )
KW - Mycobacterium
KW - PE_PGRS genes
KW - phosphate buffered saline ( PBS )
KW - quantitative real-time reverse transcription PCR ( QRT-PCR )
N1 - Accession Number: 22281760; Delogu, Giovanni 1; Email Address: gdelogu@rm.unicatt.it; Sanguinetti, Maurizio 1; Email Address: msanguinetti@rm.unicatt.it; Pusceddu, Cinzia 1,2; Email Address: c_pusceddu@hotmail.com; Bua, Alessandra 2; Email Address: ziaferita@email.it; Brennan, Michael J. 3; Email Address: brennan@cber.fda.gov; Zanetti, Stefania 2; Email Address: zanettis@uniss.it; Fadda, Giovanni 1; Email Address: giovannifadda@rm.unicatt.it; Affiliations: 1: Institute of Microbiology, Catholic University of Sacred Heart, L.go A. Gemelli, 8, 00168 Rome, Italy; 2: Department of Biomedical Sciences, University of Sassari, Viale San Pietro, 43/B, 07100 Sassari, Italy; 3: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29B, Room 1H16C HFM 400, 29 Lincoln Drive, Bethesda, MD 20892, USA; Issue Info: Jul2006, Vol. 8 Issue 8, p2061; Thesaurus Term: Tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Bone marrow; Subject Term: Killer cells; Subject Term: Gene expression; Author-Supplied Keyword: bone-marrow derived macrophages ( BMM0 ); Author-Supplied Keyword: colony-forming units ( CFU ); Author-Supplied Keyword: multiplicity of infection ( MOI ); Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: PE_PGRS genes; Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: quantitative real-time reverse transcription PCR ( QRT-PCR ); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.micinf.2006.03.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gutman, Steven
AU - Kessler, Larry G.
T1 - The US Food and Drug Administration perspective on cancer biomarker development.
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
Y1 - 2006/07//
VL - 6
IS - 7
M3 - Article
SP - 565
EP - 571
PB - Nature Publishing Group
SN - 1474175X
AB - Despite the intense interest in biomarker development for cancer management, few biomarker assays for diagnostic uses have been submitted to the US Food and Drug Administration (FDA). What challenges must researchers overcome to bring cancer-detection technologies to the market and, therefore, into clinical use? [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Cancer is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER
KW - BIOCHEMICAL markers
KW - DETECTORS
KW - HUMAN genome
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 21298677; Gutman, Steven 1; Email Address: steve.gutman@fda.hhs.gov Kessler, Larry G. 1; Affiliation: 1: Office of in vitro Diagnostic Devices and the Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, NFZ-440, 2098 Gaither Road, Rockville, Maryland 20857, USA; Source Info: Jul2006, Vol. 6 Issue 7, p565; Subject Term: CANCER; Subject Term: BIOCHEMICAL markers; Subject Term: DETECTORS; Subject Term: HUMAN genome; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1038/nrc1911
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106319336
T1 - Device safety. Oxygen delivery device can also deliver infections.
AU - Fischer RA
Y1 - 2006/07//
N1 - Accession Number: 106319336. Language: English. Entry Date: 20060818. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Bacterial Contamination
KW - Equipment Contamination
KW - Gram-Negative Aerobic Bacteria
KW - Oxygen Delivery Devices -- Adverse Effects
KW - Product Recall
KW - Bacterial Colonization
KW - Child, Preschool
KW - Infant
SP - 18
EP - 18
JO - Nursing
JF - Nursing
JA - NURSING
VL - 36
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 16816625.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bryant-Genevier, Marthe
AU - Sommer, Sandra
AU - McMahon, Ann
AU - Ball, Robert
AU - Braun, M. Miles
T1 - Correlates of Public Health Workforce Acceptance of Smallpox Immunization in Virginia.
JO - Public Health Nursing
JF - Public Health Nursing
Y1 - 2006/07//Jul/Aug2006
VL - 23
IS - 4
M3 - Article
SP - 339
EP - 346
PB - Wiley-Blackwell
SN - 07371209
AB - By October 24, 2003, 38,577 of 500,000 targeted civilians received smallpox vaccine in the Pre-Event Smallpox Vaccination Campaign, Phase I. We investigated reasons for the low vaccination uptake. Design: Cross-sectional survey, conducted in May 2004. Sample: We surveyed 225 health care personnel, potential members of smallpox response teams in Virginia, who were offered vaccination. We assessed respondents' acceptance of vaccination and its association with factors potentially influencing vaccination: perceptions of vaccine safety, contraindications, concerns about bioterrorism, and workplace influences. Results: Among nonvaccinees ( n=44), 70% had a contraindication to the vaccine compared with 8% among vaccinees ( n=132). The desire to prepare America for potential bioterrorist attack was associated with acceptance of smallpox vaccination (odds ratio [OR]: 17.7, 95% confidence interval [CI]: 3.6–85.9). Among respondents with contraindications, vaccinees reported more often than nonvaccinees having been asked by their supervisors to be vaccinated (OR: 5; 95% CI: 1.1–22.1) and to have been concerned that their vaccination choice would affect positively their job evaluation (OR: 11; 95% CI: 1.6–81.1). Conclusion: Concerns about bioterrorism and willingness to help in the preparedness effort were motivations for vaccination. Continued vigilance to avoid vaccination of those with contraindications is needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Nursing is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMALLPOX -- Vaccination
KW - HEALTH promotion
KW - HEALTH surveys
KW - MEDICAL personnel
KW - VIRAL vaccines
KW - BIOTERRORISM
KW - VIRGINIA
KW - attitudes
KW - health care personnel
KW - smallpox vaccination
N1 - Accession Number: 21396553; Bryant-Genevier, Marthe 1; Email Address: marthe.bryant-genevier@fda.hhs.gov Sommer, Sandra 2 McMahon, Ann 3 Ball, Robert 4 Braun, M. Miles 5; Affiliation: 1: CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland, 2: Epidemiologist, Division of Immunization, Virginia State Health Department, Richmond, Virginia 3: Medical Officer, CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland 4: Branch Chief, Vaccine Safety Branch, CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland 5: Division Director, Division of Epidemiology, CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, Rockville, Maryland; Source Info: Jul/Aug2006, Vol. 23 Issue 4, p339; Subject Term: SMALLPOX -- Vaccination; Subject Term: HEALTH promotion; Subject Term: HEALTH surveys; Subject Term: MEDICAL personnel; Subject Term: VIRAL vaccines; Subject Term: BIOTERRORISM; Subject Term: VIRGINIA; Author-Supplied Keyword: attitudes; Author-Supplied Keyword: health care personnel; Author-Supplied Keyword: smallpox vaccination; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1111/j.1525-1446.2006.00570.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106367564
T1 - Correlates of public health workforce acceptance of smallpox immunization in Virginia.
AU - Bryant-Genevier M
AU - Sommer S
AU - McMahon A
AU - Ball R
AU - Braun MM
Y1 - 2006/07//Jul/Aug2006
N1 - Accession Number: 106367564. Language: English. Entry Date: 20061201. Revision Date: 20160826. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 8501498.
KW - Attitude of Health Personnel -- Evaluation -- Virginia
KW - Decision Making -- Virginia
KW - Nurse Attitudes -- Evaluation -- Virginia
KW - Professional Compliance -- Evaluation -- Virginia
KW - Registered Nurses -- Virginia
KW - Smallpox Vaccine -- Administration and Dosage -- Virginia
KW - Smallpox -- Prevention and Control -- Virginia
KW - Altruism
KW - Biological Warfare
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Disaster Planning
KW - Employee Performance Appraisal
KW - Immunization Programs -- Virginia
KW - Motivation
KW - Occupational Diseases -- Prevention and Control
KW - Odds Ratio
KW - Questionnaires
KW - Surveys
KW - T-Tests
KW - Virginia
KW - Work Environment
KW - Human
SP - 339
EP - 346
JO - Public Health Nursing
JF - Public Health Nursing
JA - PUBLIC HEALTH NURS
VL - 23
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0737-1209
AD - Fellow, CBER/OBE/DE/Vaccine Safety Branch, Food and Drug Administration, 1401 Rockville Pike, Suite 268 S, HFM-222, Rockville, MD 20852-1448; marthe.bryant-genevier@fda.hhs.gov
U2 - PMID: 16817805.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Wysowski, Diane K.
T1 - INCREASE IN DEATHS RELATED ENTEROCOLITIS DUE TO CLOSTRIDIUM DIFFICILE IN THE UNITED STATES, 1999-2002.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/07//Jul/Aug2006
VL - 121
IS - 4
M3 - Letter
SP - 361
EP - 362
SN - 00333549
AB - Presents a letter to the editor about deaths related to enterocolitis due to Clostridium difficile.
KW - LETTERS to the editor
KW - CLOSTRIDIUM difficile
N1 - Accession Number: 21412649; Wysowski, Diane K. 1; Affiliation: 1: Division of Drug Risk Evaluation, Food and Drug Administration; Source Info: Jul/Aug2006, Vol. 121 Issue 4, p361; Subject Term: LETTERS to the editor; Subject Term: CLOSTRIDIUM difficile; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olempska-Beer, Zofia S.
AU - Merker, Robert I.
AU - Ditto, Mary D.
AU - DiNovi, Michael J.
T1 - Food-processing enzymes from recombinant microorganisms—a review
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/07//
VL - 45
IS - 2
M3 - Article
SP - 144
EP - 158
SN - 02732300
AB - Abstract: Enzymes are commonly used in food processing and in the production of food ingredients. Enzymes traditionally isolated from culturable microorganisms, plants, and mammalian tissues are often not well-adapted to the conditions used in modern food production methods. The use of recombinant DNA technology has made it possible to manufacture novel enzymes suitable for specific food-processing conditions. Such enzymes may be discovered by screening microorganisms sampled from diverse environments or developed by modification of known enzymes using modern methods of protein engineering or molecular evolution. As a result, several important food-processing enzymes such as amylases and lipases with properties tailored to particular food applications have become available. Another important achievement is improvement of microbial production strains. For example, several microbial strains recently developed for enzyme production have been engineered to increase enzyme yield by deleting native genes encoding extracellular proteases. Moreover, certain fungal production strains have been modified to reduce or eliminate their potential for production of toxic secondary metabolites. In this article, we discuss the safety of microorganisms used as hosts for enzyme-encoding genes, the construction of recombinant production strains, and methods of improving enzyme properties. We also briefly describe the manufacture and safety assessment of enzyme preparations and summarize options for submitting information on enzyme preparations to the US Food and Drug Administration. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microorganisms
KW - Enzymes
KW - Proteins
KW - Tissues
KW - FDA
KW - Food-processing enzymes
KW - Recombinant microorganisms
KW - Review
N1 - Accession Number: 21360302; Olempska-Beer, Zofia S.; Email Address: zofia.olempskabeer@fda.hhs.gov; Merker, Robert I. 1; Ditto, Mary D. 1; DiNovi, Michael J. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Jul2006, Vol. 45 Issue 2, p144; Thesaurus Term: Microorganisms; Subject Term: Enzymes; Subject Term: Proteins; Subject Term: Tissues; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Food-processing enzymes; Author-Supplied Keyword: Recombinant microorganisms; Author-Supplied Keyword: Review; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.05.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brahme, A.
AU - Alvi, M.H.
AU - Saylor, D.
AU - Fridy, J.
AU - Rollett, A.D.
T1 - 3D reconstruction of microstructure in a commercial purity aluminum
JO - Scripta Materialia
JF - Scripta Materialia
Y1 - 2006/07//
VL - 55
IS - 1
M3 - Article
SP - 75
EP - 80
SN - 13596462
AB - Abstract: The topic of reconstruction of polycrystalline microstructures is briefly reviewed. An example is given of using orientation maps to reconstruct digital microstructures with a representation of a polycrystal structure that includes crystallographic orientation information. The method uses packing of ellipsoids to approximate the grain structure, coupled with Voronoi tessellation. For the example of hot rolled commercial purity aluminum that was chosen, the highly elongated grain shapes required stretching of the tessellation in order to match the observed aspect ratios. [Copyright &y& Elsevier]
AB - Copyright of Scripta Materialia is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERIALS
KW - MICROMECHANICS
KW - MICROSTRUCTURE
KW - CRYSTAL grain boundaries
KW - Aluminum
KW - Microstructure reconstructions
KW - Texture
KW - Three dimensional
KW - Voronoi tessellation
N1 - Accession Number: 20749190; Brahme, A. 1; Email Address: abrahme@andrew.cmu.edu Alvi, M.H. 2 Saylor, D. 3 Fridy, J. 4 Rollett, A.D. 1; Affiliation: 1: Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890, United States 2: Intel Research, Hillsboro, OR, United States 3: Food and Drug Administration, 12725 Twinbrook Pkwy, Rockville MD 20850, United States 4: Alcoa Technical Center, Alcoa Center, PA 15609, United States; Source Info: Jul2006, Vol. 55 Issue 1, p75; Subject Term: MATERIALS; Subject Term: MICROMECHANICS; Subject Term: MICROSTRUCTURE; Subject Term: CRYSTAL grain boundaries; Author-Supplied Keyword: Aluminum; Author-Supplied Keyword: Microstructure reconstructions; Author-Supplied Keyword: Texture; Author-Supplied Keyword: Three dimensional; Author-Supplied Keyword: Voronoi tessellation; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.scriptamat.2006.02.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Solano-Lopez, Claudia
AU - Ziedler-Erdely, Patti C.
AU - Hubbs, Ann F.
AU - Reynolds, Steven H.
AU - Roberts, Jenny R.
AU - Taylor, Michael D.
AU - Young, Shih-Houng
AU - Castranova, Vincent
AU - Antonini, James M.
T1 - Welding Fume Exposure and Associated Inflammatory and Hyperplastic Changes in the Lungs of Tumor Susceptible A/J Mice.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2006/07//
VL - 34
IS - 4
M3 - Article
SP - 364
EP - 372
SN - 01926233
AB - It has been suggested that welding fume (WF) exposure increases lung cancer risk in welders. Epidemiology studies have failed to conclude that WF alone causes lung cancer and animal studies are lacking. We examined the course of inflammation, damage, and repair in the lungs of A/J mice, a lung tumor susceptible strain, caused by stainless steel WF. Mice were exposed by pharyngeal aspiration to 40 mg/kg of WF, silica, or saline. Bronchoalveolar lavage (BAL) was performed 24 hours, 1 and 16 weeks to assess lung injury and inflammation and histopathology was done 1, 8, 16, 24, and 48 weeks postexposure. Both exposures increased inflammatory cells, lactate dehydrogenase and albumin at 24 hr and 1 week. At 16 weeks, these parameters remained elevated in silica-exposed but not WF-exposed mice. Histopathologic evaluation at 1 week indicated that WF induced bronchiolar epithelial hyperplasia with associated cellular atypia, alveolar bronchiolo-alveolar hyperplasia (BAH) in peribronchiolar alveoli, and peribronchiolar lymphogranulomatous inflammation. Persistent changes included foci of histiocytic inflammation, fibrosis, atypical bronchiolar epithelial cells, and bronchiolar BAH. The principle changes in silica-exposed mice were histiocytic and suppurative inflammation, fibrosis, andalveolar BAH. Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Silicon compounds
KW - Health risk assessment
KW - Industrial safety
KW - Welding -- Health aspects
KW - Lungs -- Cancer
KW - Silica -- Safety measures
KW - bronchoalveolar hyperplasia
KW - lung inflammation
KW - SILICA
KW - strain A mice
KW - Welding fume
N1 - Accession Number: 21795815; Solano-Lopez, Claudia 1; Ziedler-Erdely, Patti C. 1; Hubbs, Ann F. 1; Reynolds, Steven H. 1; Roberts, Jenny R. 1; Taylor, Michael D. 1; Young, Shih-Houng 1; Castranova, Vincent 1; Antonini, James M. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Issue Info: 2006, Vol. 34 Issue 4, p364; Thesaurus Term: Silicon compounds; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial safety; Subject Term: Welding -- Health aspects; Subject Term: Lungs -- Cancer; Subject Term: Silica -- Safety measures; Author-Supplied Keyword: bronchoalveolar hyperplasia; Author-Supplied Keyword: lung inflammation; Author-Supplied Keyword: SILICA; Author-Supplied Keyword: strain A mice; Author-Supplied Keyword: Welding fume; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 9p; Illustrations: 9 Color Photographs, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Murashov, Vladimir
T1 - Comments on “Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles” by Yang, L., Watts, D.J., Toxicology Letters, 2005, 158, 122–132.
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2006/07//
VL - 164
IS - 2
M3 - Letter
SP - 185
EP - 187
SN - 03784274
KW - Alumina
KW - Aluminum
KW - Nanoparticle
KW - Phytotoxicity
N1 - Accession Number: 20731340; Murashov, Vladimir 1; Email Address: VMurashov@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, 200 Independence Ave., SW, Room 715-H, Washington, DC 20201, United States; Issue Info: Jul2006, Vol. 164 Issue 2, p185; Author-Supplied Keyword: Alumina; Author-Supplied Keyword: Aluminum; Author-Supplied Keyword: Nanoparticle; Author-Supplied Keyword: Phytotoxicity; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.toxlet.2006.03.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Abraham, Ann
AU - Plakas, Steven M.
AU - Wang, Zhihong
AU - Jester, Edward L.E.
AU - El Said, Kathleen R.
AU - Granade, Hudson R.
AU - Henry, Michael S.
AU - Blum, Patricia C.
AU - Pierce, Richard H.
AU - Dickey, Robert W.
T1 - Characterization of polar brevetoxin derivatives isolated from Karenia brevis cultures and natural blooms
JO - Toxicon
JF - Toxicon
Y1 - 2006/07//
VL - 48
IS - 1
M3 - Article
SP - 104
EP - 115
SN - 00410101
AB - Abstract: Several novel brevetoxin derivatives were isolated and identified in Karenia brevis cultures and natural blooms by using solid phase extraction (SPE) and LC/MS(MS) techniques. These analogs were more polar compared with previously described brevetoxins, and were poorly extractable by conventional non-polar solvent (chloroform) partitioning. Brevetoxin analogs were structurally confirmed as hydrolyzed (open A-ring) forms of brevetoxins PbTx-1, PbTx-7, PbTx-2, and PbTx-3, and of oxidized PbTx-1 and PbTx-2. Some of these open A-ring derivatives were in greater abundance than their non-hydrolyzed counterparts. All were in much greater abundance in bloom water filtrate compared with cell-rich fractions. Open A-ring compounds were cytotoxic in mouse neuroblastoma (N2a) cell assay. In the K. brevis bloom-exposed Eastern oyster, brevetoxin metabolites with opened A rings were identified (e.g., open-ring cysteine-PbTx conjugates), contributing to their overall toxin burden. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTINEOPLASTIC antibiotics
KW - CELL culture
KW - TOXINS
KW - BIOTECHNOLOGY
KW - Brevetoxins
KW - Eastern oyster
KW - Karenia brevis
KW - LC/MS
N1 - Accession Number: 21574952; Abraham, Ann 1; Email Address: ann.abraham@fda.hhs.gov Plakas, Steven M. 1 Wang, Zhihong 1 Jester, Edward L.E. 1 El Said, Kathleen R. 1 Granade, Hudson R. 1 Henry, Michael S. 2 Blum, Patricia C. 2 Pierce, Richard H. 2 Dickey, Robert W. 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA 2: Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA; Source Info: Jul2006, Vol. 48 Issue 1, p104; Subject Term: ANTINEOPLASTIC antibiotics; Subject Term: CELL culture; Subject Term: TOXINS; Subject Term: BIOTECHNOLOGY; Author-Supplied Keyword: Brevetoxins; Author-Supplied Keyword: Eastern oyster; Author-Supplied Keyword: Karenia brevis; Author-Supplied Keyword: LC/MS; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.toxicon.2006.04.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21574952&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martinez, Marilyn
AU - McDermott, Patrick
AU - Walker, Robert
T1 - Pharmacology of the fluoroquinolones: A perspective for the use in domestic animals.
JO - Veterinary Journal
JF - Veterinary Journal
Y1 - 2006/07//
VL - 172
IS - 1
M3 - Article
SP - 10
EP - 28
SN - 10900233
AB - The fluoroquinolones are a class of compounds that comprise a large and expanding group of synthetic antimicrobial agents. Structurally, all fluoroquinolones contain a fluorine molecule at the 6-position of the basic quinolone nucleus, Despite the basic similarity in the core structure of these molecules, their physicochemical properties, pharmacokinetic characteristics and microbial activities can vary markedly across compounds. The first of the fluoroquinolones approved for use in animals, enrofloxacin, was approved in the late 1980s. Since then, five other fluoroquinolones have been marketed for use in animals in the United States, with others currently under investigation. This review focuses on the use of fluoroquinolones within veterinary medicine, providing an overview of the structure-activity relationship of the various members of the group, the clinical uses of fluoroquinolones in veterinary medicine, their pharmacokinetics and potential interspecies differences, an overview of the current understanding of the pharmacokinetic/pharmacodynamic relationships associated with fluoroquinolones, a summary of toxicities that have been associated with this class of compounds, their use in both in human and veterinary species, mechanisms associated with the development of microbial resistance to the fluoroquinolones, and a discussion of fluoroquinolone dose optimization. Although the review contains a large body of basic research information, it is intended that the contents of this review have relevance to both the research scientist and the veterinary medical practitioner. [ABSTRACT FROM AUTHOR]
AB - Copyright of Veterinary Journal is the property of W B Saunders and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - FLUORINE compounds
KW - QUINOLONE antibacterial agents
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - VETERINARY medicine
KW - Fluoroquinolones
KW - Pharmacodynamics
KW - Pharmacokinetics
KW - Resistance
KW - Veterinary
N1 - Accession Number: 21617147; Martinez, Marilyn 1 McDermott, Patrick 2 Walker, Robert 2; Email Address: rwalker@cvm.fda.gov; Affiliation: 1: US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 20855, USA 2: US Food and Drug Administration, Center for Veterinary Medicine, Division of Animal and Food Microbiology, Office of Research, Laurel, MD 20708, USA; Source Info: Jul2006, Vol. 172 Issue 1, p10; Subject Term: ANTI-infective agents; Subject Term: FLUORINE compounds; Subject Term: QUINOLONE antibacterial agents; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Subject Term: VETERINARY medicine; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Pharmacodynamics; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Resistance; Author-Supplied Keyword: Veterinary; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 19p; Illustrations: 2 Diagrams, 7 Charts; Document Type: Article
L3 - 10.1016/j.tvjl.2005.07.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Howell-Jones, Rebecca S.
AU - Price, Patricia E.
AU - Howard, Anthony J.
AU - Thomas, David W.
T1 - Antibiotic prescribing for chronic skin wounds in primary care.
JO - Wound Repair & Regeneration
JF - Wound Repair & Regeneration
Y1 - 2006/07//Jul/Aug2006
VL - 14
IS - 4
M3 - Article
SP - 387
EP - 393
PB - Wiley-Blackwell
SN - 10671927
AB - The aim of this study was to describe and quantify systemic antibiotic prescribing for patients with chronic skin wounds presenting at the primary care, nonspecialist setting. Data for 1 year were extracted from a general practice morbidity database comprising approximately 185,000 patients attending family medical practitioners in Wales. Patients with chronic wounds (PCW) were identified using Read Codes and compared with nonwound patients who were randomly selected after matching for age-band, sex, and general practice. PCW received a significantly greater number of antibiotic courses than nonwound patients ( p<0.001). This increased level of prescribing was evident for flucloxacillin, co-amoxiclav, cefaclor, cefalexin, erythromycin, trimethoprim, metronidazole, and ciprofloxacin ( p<0.01 for all). While PCW also had a significantly higher prevalence of diabetes (16.5% compared with 6.6%, p<0.001), and attended at general practice significantly more frequently than nonwound patients (median (interquartile range) of 25 (17–40) visits per year compared with 12 (4–20), p<0.001), importantly, exclusion of diabetic patients and analysis of the proportion of visits on which patients received antibiotics did not affect the significance of the difference in antibiotic consumption. These data show a strong association between occurrence of chronic wounds and prescribing of antibiotics in primary health care, and wide variation in the type and duration of antibiotic therapy for chronic wounds. Further work is now indicated to rationalize this prescribing and determine the role that this exposure to antibiotics plays in the prevalence of antibiotic resistance in this at-risk elderly population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wound Repair & Regeneration is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Wounds & injuries -- Treatment
KW - ANTIBIOTICS -- Therapeutic use
KW - PRESCRIPTION of drugs
KW - PRIMARY care (Medicine)
KW - WOUND healing
N1 - Accession Number: 22019211; Howell-Jones, Rebecca S. 1; Email Address: Howell-JonesRS@cf.ac.uk Price, Patricia E. 2,3 Howard, Anthony J. 4 Thomas, David W. 1,3; Affiliation: 1: Wound Biology Group and Department of Oral Surgery, Medicine and Pathology, Wales College of Medicine, Cardiff University 2: Wound Healing Research Unit, Cardiff Medicentre, Heath Park 3: Cardiff Institute of Tissue Engineering and Repair, Wales College of Medicine, Cardiff University 4: Infection and Communicable Disease Services, National Public Health Service for Wales, Temple of Peace and Health, Cardiff, Wales, United Kingdom; Source Info: Jul/Aug2006, Vol. 14 Issue 4, p387; Subject Term: SKIN -- Wounds & injuries -- Treatment; Subject Term: ANTIBIOTICS -- Therapeutic use; Subject Term: PRESCRIPTION of drugs; Subject Term: PRIMARY care (Medicine); Subject Term: WOUND healing; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1743-6109.2006.00144.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Horvath-Arcidiacono, Judith A.
AU - Porter, Cynthia M.
AU - Bloom, Eda T.
T1 - Human NK cells can lyse porcine endothelial cells independent of their expression of Galα(1,3)-Gal and killing is enhanced by activation of either effector or target cells.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2006/07//
VL - 13
IS - 4
M3 - Article
SP - 318
EP - 327
PB - Wiley-Blackwell
SN - 0908665X
AB - Background: Xenotransplantation of pig organs may provide an approach to alleviate the severe shortage of human organs. Natural antibodies against Gal α(1,3)-Gal ( αGal) epitopes cause hyperacute rejection of pig organs in primates. However, evidence for the role of αGal in the natural killer (NK) cell-mediated xenoresponse has been contradictory. Methods: We investigated the recognition of αGal by human NK cells using endo- β-galactosidase C, an enzyme that cleaves αGal, and endothelial cells (EC) from α1,3-galactosyltransferase null pigs that do not synthesize αGal. Endo- β-galactosidase C treatment variably reduced the susceptibility of porcine EC to lysis by fresh human NK cells. Results: Removal of αGal from porcine EC using endo- β-galactosidase C, produced variable results, i.e. cytotoxicity was decreased in half of the human NK cell donors tested. The two EC strains from αGal−/− pigs were marginally, and not significantly, less susceptible to lysis by naïve human NK cells compared with αGal-expressing cells obtained from animals from the same herd, but these differences were not statistically significant ( P > 0.10). Treatment of porcine EC with recombinant human tumor necrosis factor (TNF)- α, which is known to activate porcine EC, enhanced the susceptibility of all target cells to lysis by fresh human NK cells. Surface expression of MHC or adhesion molecules on αGal−/− cells, compared with wild type cells, showed no consistent difference in either MHC or adhesion molecules CD106 (VCAM-1), CD31 (PECAM) or CD62E (E-selectin), either with or without TNF- α stimulation, that could explain the differential susceptibility to lysis. Strikingly, all αGal−/− and wild type EC exhibited similar susceptibility to human NK cells that had been cultured for 5 days with or without interleukin-2. Conclusions: These findings demonstrate that human NK cells can kill porcine targets in the absence of αGal, and donor variability plays a major role in whether αGal has a role in determining susceptibility of porcine EC to lysis. Moreover, susceptibility to lysis of αGal null EC is enhanced to the level of wild type EC by activation of either effector or target cells. Elimination of αGal alone from source pigs will be insufficient to circumvent the NK cell mediated destruction of porcine EC. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenotransplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - RESEARCH
KW - SWINE as laboratory animals
KW - KILLER cells
KW - INTERLEUKIN-2
KW - IMMUNOGLOBULINS
KW - human
KW - natural killer cells
KW - pig
KW - tumor necrosis factor- α
KW - tumor necrosis factor-α
KW - xenotransplantation
N1 - Accession Number: 21097321; Horvath-Arcidiacono, Judith A. 1 Porter, Cynthia M. 1 Bloom, Eda T. 1; Email Address: bloom@cber.fda.gov; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA; Source Info: Jul2006, Vol. 13 Issue 4, p318; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: RESEARCH; Subject Term: SWINE as laboratory animals; Subject Term: KILLER cells; Subject Term: INTERLEUKIN-2; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: human; Author-Supplied Keyword: natural killer cells; Author-Supplied Keyword: pig; Author-Supplied Keyword: tumor necrosis factor- α; Author-Supplied Keyword: tumor necrosis factor-α; Author-Supplied Keyword: xenotransplantation; Number of Pages: 10p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1111/j.1399-3089.2006.00316.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21097321&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kyoung Sik Park
AU - Deuk Yong Sung
T1 - Infectious disease control in relation to xenotransplantation in Korea.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2006/07//
VL - 13
IS - 4
M3 - Letter
SP - 366
EP - 367
PB - Wiley-Blackwell
SN - 0908665X
AB - A letter to the editor is presented regarding the infectious disease control in relation to xenotransplantation in Korea.
KW - LETTERS to the editor
KW - TRANSPLANTATION of organs, tissues, etc.
KW - RESEARCH
N1 - Accession Number: 21097328; Kyoung Sik Park 1,2; Email Address: pks0322@hanmail.net Deuk Yong Sung 1,3; Email Address: dysung@kfda.go.kr; Affiliation: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, Eunpyung-ku 2: Natural Products Research Institute, College of Pharmacy, Seoul National University, Jongro-ku 3: Department of Food and Animal Biotechnology, College of Agriculture and Life Science, Seoul National University, Sinlim-dong, Kwanak-ku, Seoul, South Korea; Source Info: Jul2006, Vol. 13 Issue 4, p366; Subject Term: LETTERS to the editor; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: RESEARCH; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Letter
L3 - 10.1111/j.1399-3089.2006.00301.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21097328&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-20675-003
AN - 2006-20675-003
AU - Huang, Boji
AU - Grant, Bridget F.
AU - Dawson, Deborah A.
AU - Stinson, Frederick S.
AU - Chou, S. Patricia
AU - Saha, Tulshi D.
AU - Goldstein, Risë B.
AU - Smith, Sharon M.
AU - Ruan, W. June
AU - Pickering, Roger P.
T1 - Race-ethnicity and the prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and Axis I and II disorders: United States, 2001 to 2002.
JF - Comprehensive Psychiatry
JO - Comprehensive Psychiatry
JA - Compr Psychiatry
Y1 - 2006/07//Jul-Aug, 2006
VL - 47
IS - 4
SP - 252
EP - 257
CY - Netherlands
PB - Elsevier Science
SN - 0010-440X
SN - 1532-8384
AD - Huang, Boji, Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US, 20892-9304
N1 - Accession Number: 2006-20675-003. PMID: 16769298 Partial author list: First Author & Affiliation: Huang, Boji; Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20061204. Correction Date: 20160407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Diagnostic and Statistical Manual; Drug Abuse; Epidemiology; Racial and Ethnic Differences. Minor Descriptor: Alcohol Abuse. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul-Aug, 2006.
AB - The objective of this study was to compare the current prevalence and co-occurrence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, alcohol and drug use disorders and mood, anxiety, and personality disorders among whites, blacks, Native Americans, Asians, and Hispanics in a large representative sample of the US population. Striking mental health disparities were observed in the prevalences of psychiatric disorders, especially among Native Americans. Disparities in psychiatric comorbidity differed from those associated with prevalence. Most significantly, the association between alcohol disorders and personality disorders was significantly greater among Asians relative to whites, blacks, and Native Americans, despite lower prevalences of these disorders among Asians. Taken together, the results of this study highlight the need of future studies that help unravel the risk factors underlying the disparities in both prevalence and comorbidity of psychiatric disorders observed among race-ethnic groups in the United States. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Diagnostic and Statistical Manual of Mental Disorders
KW - alcohol use disorder
KW - drug use disorder
KW - prevalence
KW - co-occurrence
KW - racial and ethnic differences
KW - 2006
KW - Comorbidity
KW - Diagnostic and Statistical Manual
KW - Drug Abuse
KW - Epidemiology
KW - Racial and Ethnic Differences
KW - Alcohol Abuse
KW - 2006
U1 - Sponsor: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, US. Recipients: No recipient indicated
DO - 10.1016/j.comppsych.2005.11.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20675-003&site=ehost-live&scope=site
UR - HuangBo@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-11043-007
AN - 2006-11043-007
AU - Sussman, Andrew L.
AU - Williams, Robert L.
AU - Leverence, Robert
AU - Gloyd, Park W.
AU - Crabtree, Benjamin F.
T1 - The Art and Complexity of Primary Care Clinicians' Preventive Counseling Decisions: Obesity as a Case Study.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2006/07//Jul-Aug, 2006
VL - 4
IS - 4
SP - 327
EP - 333
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Sussman, Andrew L., Department of Family and Community Medicine, University of New Mexico, MSC09 5040, 1, Albuquerque, NM, US, 87131
N1 - Accession Number: 2006-11043-007. PMID: 16868236 Partial author list: First Author & Affiliation: Sussman, Andrew L.; Department of Family and Community Medicine, University of New Mexico, Albuquerque, NM, US. Release Date: 20061030. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the North American Primary Care Research Group, Oct, 2004, Orlando, FL, US. Conference Note: Portions of this research were presented at the aforementioned conference and the Society for Applied Anthropology, April 2005, Santa Fe, NM; and at the Navajo Nation Research Review Board Conference, June 2005, Window Rock, Ariz. Major Descriptor: Clinicians; Counseling; Obesity; Preventive Medicine; Primary Health Care. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Clinical Case Study; Empirical Study; Qualitative Study; Quantitative Study. Supplemental Data: Appendixes Internet; Tables and Figures Internet. References Available: Y. Page Count: 7. Issue Publication Date: Jul-Aug, 2006.
AB - Purpose: Studies have often shown low rates of preventive counseling in primary care, and interventions aimed at improving counseling rates have had disappointing results. Using obesity as a case study, we looked for factors that influence clinicians' decisions to include preventive counseling in the brief primary care encounter. Methods: A sequential, mixed methods study was conducted among clinicians in RIOS (Research Involving Outpatient Settings) Net, a Southwestern US practice-based research network. Thirty primary care clinicians participated in in-depth interviews or analytic focus groups, and 75% of 195 network members responded to a survey used to estimate the frequency of factors influencing decisions to undertake preventive counseling. Results: Clinicians described a complex set of factors that influence decisions to provide preventive counseling for obesity. These can be grouped into 2 sets of factors: (1) relatively stable factors that 'set the stage' for the encounter, such as the clinician's life values, definitions of success, and the availability of community resources; and (2) factors that are more dynamic, exerting their influence 'as the door opens' into the examination room. These factors include the patient's agenda and receptivity to the proposed counseling, as well as the presence of teachable moments. Clinician, patient, and external factors are found in both groups. Conclusions: Clinician decisions to include obesity and other types of preventive counseling in the brief encounter reflect the art and complexity of management of the encounter. Future efforts to enhance the delivery of preventive counseling will need to move beyond linear models of behavior change to recognize this complex environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - primary care clinicians
KW - preventive counseling decisions
KW - obesity
KW - 2006
KW - Clinicians
KW - Counseling
KW - Obesity
KW - Preventive Medicine
KW - Primary Health Care
KW - 2006
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 5 R21 HS013496. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Grant: 8 D54 HP 00032-04. Recipients: No recipient indicated
DO - 10.1370/afm.566
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11043-007&site=ehost-live&scope=site
UR - asussman@salud.unm.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00503-006
AN - 2007-00503-006
AU - Johnston, Linda L.
AU - Ammary, Neyal J.
AU - Epstein, Leonard G.
AU - Johnson, Rae
AU - Rhee, Kyu
T1 - A Transdisciplinary Approach to Improve Health Literacy and Reduce Disparities.
JF - Health Promotion Practice
JO - Health Promotion Practice
JA - Health Promot Pract
Y1 - 2006/07//
VL - 7
IS - 3
SP - 331
EP - 335
CY - US
PB - Sage Publications
SN - 1524-8399
SN - 1552-6372
N1 - Accession Number: 2007-00503-006. Partial author list: First Author & Affiliation: Johnston, Linda L.; Center for Quality, Health Resources and Services Administration (HRSA), Rockville, MD, US. Release Date: 20070528. Correction Date: 20111031. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Health Education; Health Knowledge; Literacy; Public Health. Minor Descriptor: Health Care Services; Medical Personnel; Health Literacy. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: Jul, 2006.
AB - A challenge to public health professionals, health care providers, and consumers is to come together to improve the quality of health care and to eliminate disparities. Improving health literacy skills along with a transdisciplinary approach to care contributes to effective patient-provider communication. This article addresses a team approach to health care, a community health center experience, self-management skills, patient education, and cultural competency training. In addition, the authors provide concepts that can be incorporated in health care settings to eliminate health disparities and improve health literacy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health literacy
KW - disparities
KW - public health professionals
KW - health care providers
KW - 2006
KW - Health Care Delivery
KW - Health Education
KW - Health Knowledge
KW - Literacy
KW - Public Health
KW - Health Care Services
KW - Medical Personnel
KW - Health Literacy
KW - 2006
DO - 10.1177/1524839906289378
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00503-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09437-010
AN - 2006-09437-010
AU - Hanmer, Janel
AU - Lawrence, William F.
AU - Anderson, John P.
AU - Kaplan, Robert M.
AU - Fryback, Dennis G.
T1 - Report of Nationally Representative Values for the Noninstitutionalized US Adult Population for 7 Health-Related Quality-of-Life Scores.
JF - Medical Decision Making
JO - Medical Decision Making
JA - Med Decis Making
Y1 - 2006/07//Jul-Aug, 2006
VL - 26
IS - 4
SP - 391
EP - 400
CY - US
PB - Sage Publications
SN - 0272-989X
SN - 1552-681X
AD - Hanmer, Janel, Department of Population Health Sciences, University of Wisconsin- Madison, 644 WARF, 610 Walnut St., Madison, WI, US, 53726
N1 - Accession Number: 2006-09437-010. PMID: 16855127 Partial author list: First Author & Affiliation: Hanmer, Janel; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, US. Release Date: 20070129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Quality of Life; Rating Scales; Test Norms; Test Scores. Classification: Health Psychology Testing (2226); Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: EuroQol-5D; SF-12; SF-6D; Quality of Well-being Scale; National Health Interview Survey; Visual Analogue Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul-Aug, 2006.
AB - Background: Despite widespread use of generic health-related quality-of-life (HRQoL) scores, few have publicly published nationally representative US values. Purpose: To create current nationally representative values for 7 of the most common HRQoL scores, stratified by age and sex. Methods: The authors used data from the 2001 Medical Expenditures Panel Survey (MEPS) and the 2001 National Health Interview Survey (NHIS), nationally representative surveys of the US noninstitutionalized civilian population. The MEPS was used to calculate 6 HRQoL scores: categorical self-rated health, EuroQoL-5D with US scoring, EuroQoL-5D with UK scoring, EuroQol Visual Analog Scale, mental and physical component summaries from the SF-12, and the SF-6D. The authors estimated Quality of Well-being scale scores from the NHIS. Results: They included 22,523 subjects from MEPS 2001 and 32,472 subjects from NHIS 2001. Most age and sex categories had instrument completion rates above 85%. Females reported lower scores than males across all ages and instruments. In general, those in older age groups reported lower scores than younger age groups, with the exception of the mental component summary from the SF-12. Conclusion: This is one of the first sets of publicly available, nationally representative US values for any standardized HRQoL measure. These values are important for use in both generalized comparisons of health status and in cost-effectiveness analyses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nnoinstitutionalized US adult population
KW - health related quality of life
KW - national norms
KW - well being
KW - rating scales
KW - 2006
KW - Health
KW - Quality of Life
KW - Rating Scales
KW - Test Norms
KW - Test Scores
KW - 2006
U1 - Sponsor: National Institute on Aging, US. Grant: P01 G206079-01. Recipients: No recipient indicated
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: HS000083. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention, Quality of Well-Being Scale. Other Details: MOVE, Physical Activity and Health Branch, Division of Nutrition and Physical Activity. Recipients: No recipient indicated
U1 - Sponsor: Robert Wood Johnson Foundation. Recipients: No recipient indicated
DO - 10.1177/0272989X06290497
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09437-010&site=ehost-live&scope=site
UR - jehanmer@wisc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09479-001
AN - 2006-09479-001
AU - Mizuno, Y.
AU - Wilkinson, J. D.
AU - Santibanez, S.
AU - Rose, C. Dawson
AU - Knowlton, A.
AU - Handley, K.
AU - Gourevitch, M. N.
T1 - Correlates of health care utilization among HIV-seropositive injection drug users.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2006/07//
VL - 18
IS - 5
SP - 417
EP - 425
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Mizuno, Y., Prevention Research Branch, Division of HIV/AIDS Prevention, National Center for HIV/STD/TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, NE Mail Stop E37, Atlanta, GA, US, 30333
N1 - Accession Number: 2006-09479-001. PMID: 16777632 Partial author list: First Author & Affiliation: Mizuno, Y.; Centers for Disease Control and Prevention, Atlanta, GA, US. Institutional Authors: Inspire Team. Release Date: 20060828. Correction Date: 20160811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Health Behavior; Health Care Services; Health Care Utilization; HIV. Minor Descriptor: Intravenous Drug Usage. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Audio-Computer Assisted Self Interview; Engagement With Health Care Provider Scale DOI: 10.1037/t50211-000; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2006.
AB - This study sought to identify correlates of poor health care utilization among HIV-positive injection drug users (IDUs) using Andersen's behavioural health model. We used baseline data from INSPIRE, a study of HIV-positive IDUs (n = 1161) to identify predisposing, enabling, and need factors related to poor utilization (defined as fewer than two outpatient visits in the past six months, or identification of emergency room (ER) as the usual place for care). Using bivariate and multivariate models, we found a number of enabling factors that could facilitate the use of health care services such as having health insurance, having seen a case manager, and better engagement with health care providers. These enabling factors could be modified through interventions targeting HIV-positive IDUs. In addition, health insurance and case management appear to be important factors to address because they contributed in making other factors (e.g. lower education, lack of stable housing) non-significant barriers to outpatient care utilization. In the future, these findings may be used to inform the development of interventions that maximize use of scarce HIV resources and improve health care utilization among HIV-positive IDUs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care utilization
KW - HIV
KW - injection drug users
KW - health behavior
KW - health insurance
KW - health care providers
KW - 2006
KW - Drug Abuse
KW - Health Behavior
KW - Health Care Services
KW - Health Care Utilization
KW - HIV
KW - Intravenous Drug Usage
KW - 2006
DO - 10.1080/09540120500162247
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09479-001&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6865-2126
UR -
UR - ymizuno@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08833-005
AN - 2006-08833-005
AU - Rosenthal, Meredith B.
AU - Minden, Sarah
AU - Manderscheid, Ronald
AU - Henderson, Marilyn
T1 - A Typology of Organizational and Contractual Arrangements for Purchasing and Delivery of Behavioral Health Care.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2006/07//
VL - 33
IS - 4
SP - 461
EP - 469
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Rosenthal, Meredith B., Harvard School of Public Health, 677 Huntington Avenue, Room 405, Boston, MA, US, 02115
N1 - Accession Number: 2006-08833-005. PMID: 16382276 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Rosenthal, Meredith B.; Harvard School of Public Health, Boston, MA, US. Release Date: 20060724. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Delivery; Mental Health Services; Organizations; Quality of Care. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2006.
AB - The evolution of behavioral health care financing and delivery has led to a wide variety of arrangements connecting consumers to behavioral health services. In this paper, we present a typology based on three distinguishing features of behavioral health arrangements along which there is a high degree of variability and this variability has been shown to affect the cost and quality of behavioral health care: (1) the extent to which sponsor oversight over care is outsourced by way of contracts rather than performed directly; (2) whether financing for behavioral health is partitioned from health care financing overall; and (3) the amount of financial risk shared by the sponsor with third parties. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral health care & arrangements
KW - health care cost
KW - health care quality
KW - health care delivery
KW - 2006
KW - Health Care Costs
KW - Health Care Delivery
KW - Mental Health Services
KW - Organizations
KW - Quality of Care
KW - 2006
U1 - Sponsor: SAMSHA. Grant: 280-99-4005. Recipients: No recipient indicated
DO - 10.1007/s10488-005-0025-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08833-005&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-3410-0184
UR - mrosenth@hsph.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08489-010
AN - 2006-08489-010
AU - Houck, Christopher D.
AU - Lescano, Celia M.
AU - Brown, Larry K.
AU - Tolou-Shams, Marina
AU - Thompson, Jonathon
AU - DiClemente, Ralph
AU - Fernandez, M. Isabel
AU - Pugatch, David
AU - Schlenger, William E.
AU - Silver, Barbara J.
T1 - 'Islands of risk': Subgroups of adolescents at risk for HIV.
JF - Journal of Pediatric Psychology
JO - Journal of Pediatric Psychology
JA - J Pediatr Psychol
Y1 - 2006/07//
VL - 31
IS - 6
SP - 619
EP - 629
CY - United Kingdom
PB - Oxford University Press
SN - 0146-8693
SN - 1465-735X
AD - Houck, Christopher D., Bradley/Hasbro Children's Research Center, One Hoppin Street, Suite 204, Providence, RI, US, 02903
N1 - Accession Number: 2006-08489-010. PMID: 16120764 Partial author list: First Author & Affiliation: Houck, Christopher D.; Rhode Island Hospital and Brown Medical Center, Providence, RI, US. Release Date: 20060821. Correction Date: 20131104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; At Risk Populations; HIV; Sexual Risk Taking. Classification: Immunological Disorders (3291); Sexual Behavior & Sexual Orientation (2980). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul, 2006.
AB - Objective: To use cluster analysis to determine profiles of adolescents at risk for HIV. Methods: Adolescents 15-21 years old (N = 1153) with a history of unprotected sex were assessed in five domains of risk (unprotected sex, alcohol/marijuana use, other drug use, mental health crises, and arrest/school dropout) as well as demographic, contextual, and behavioral variables. Results: Cluster analysis revealed separate three-cluster solutions for males and females. Among males, clusters were characterized by (a) mental health crises and unprotected sex, (b) alcohol/marijuana use and unprotected sex, and (c) lower risk. Among females, clusters were distinguished by (a) unprotected sex, (b) substance use and mental health crises, and (c) lower risk. Cluster membership was associated with secondary variables related to sexual risk. Conclusions: Even within populations of high-risk adolescents, subgroups exist for which specific risk factors co-occur, particularly unprotected sex, mental health crises, and substance use. These patterns suggest that effective HIV prevention interventions may need to target the association between mental health and/or substance abuse with sexual risk for some adolescents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescents
KW - HIV
KW - sexual risk
KW - at risk populations
KW - 2006
KW - Adolescent Development
KW - At Risk Populations
KW - HIV
KW - Sexual Risk Taking
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: U10 SMS2073. Other Details: Rhode Island Hospital, Miriam Hospital, Emory University, and University of Miami. Recipients: No recipient indicated
DO - 10.1093/jpepsy/jsj067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08489-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08920-009
AN - 2006-08920-009
AU - Kaida, Kosuke
AU - Takahashi, Masaya
AU - Åkerstedt, Torbjörn
AU - Nakata, Akinori
AU - Otsuka, Yasumasa
AU - Haratani, Takashi
AU - Fukasawa, Kenji
T1 - Validation of the Karolinska sleepiness scale against performance and EEG variables.
JF - Clinical Neurophysiology
JO - Clinical Neurophysiology
JA - Clin Neurophysiol
Y1 - 2006/07//
VL - 117
IS - 7
SP - 1574
EP - 1581
CY - Netherlands
PB - Elsevier Science
SN - 1388-2457
AD - Kaida, Kosuke
N1 - Accession Number: 2006-08920-009. PMID: 16679057 Other Journal Title: Electroencephalography & Clinical Neurophysiology. Partial author list: First Author & Affiliation: Kaida, Kosuke; Japan National Institute of Occupational Safety and Health, Kawasaki, Japan. Release Date: 20070116. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Electroencephalography; Psychometrics; Sleep; Test Reliability; Test Validity. Minor Descriptor: Sleep Onset. Classification: Tests & Testing (2220); Physiological Processes (2540). Population: Human (10); Female (40). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Psychomotor Vigilance Task; Karolinska Drowsiness Test; Alpha Attenuation Test; Karolinska Sleepiness Scale; Morningness-Eveningness Questionnaire DOI: 10.1037/t02254-000; Center for Epidemiologic Studies Depression Scale; Visual Analogue Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2006.
AB - Objective: The Karolinska sleepiness scale (KSS) is frequently used for evaluating subjective sleepiness. The main aim of the present study was to investigate the validity and reliability of the KSS with electroencephalographic, behavioral and other subjective indicators of sleepiness. Methods: Participants were 16 healthy females aged 33-43 (38.1 ± 2.68) years. The experiment involved 8 measurement sessions per day for 3 consecutive days. Each session contained the psychomotor vigilance task (PVT), the Karolinska drowsiness test (KDT--EEG alpha & theta power), the alpha attenuation test (AAT--alpha power ratio open/closed eyes) and the KSS. Results: Median reaction time, number of lapses, alpha and theta power density and the alpha attenuation coefficients (AAC) showed highly significant increase with increasing KSS. The same variables were also significantly correlated with KSS, with amean value for lapses (r = 0.56). Conclusions: The KSS was closely related to EEG and behavioral variables, indicating a high validity in measuring sleepiness. Significance: KSS ratings may be a useful proxy for EEG or behavioral indicators of sleepiness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Karolinska Sleepiness Scale
KW - test validity
KW - electroencephalography
KW - test reliability
KW - psychometrics
KW - 2006
KW - Electroencephalography
KW - Psychometrics
KW - Sleep
KW - Test Reliability
KW - Test Validity
KW - Sleep Onset
KW - 2006
DO - 10.1016/j.clinph.2006.03.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08920-009&site=ehost-live&scope=site
UR - kaida-kosuke@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Getting To 'Smart' Health Care.
JO - Health Affairs
JF - Health Affairs
Y1 - 2006/07/02/2006 Web Exclusives
VL - 25
M3 - Article
SP - w589
EP - w592
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - As the United States struggles with improving the return on its sizable health care investment and consumers become increasingly involved in health care decisions, interest in comparative effectiveness will rise because of its relevance to value, personalized health care, quality, and cost containment. Advances in biomedicine and health information technology present exciting opportunities for providing timely, relevant information about the comparative effectiveness of health care services. Successful growth will require a transparent, participatory approach and new partnerships between the public and private sectors to achieve the goal of producing valid evidence for decision making. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - MEDICAL innovations
KW - MEDICAL care costs
KW - MEDICINE
KW - MEDICAL informatics
KW - COST effectiveness
KW - MEDICAL technology
N1 - Accession Number: 25072636; Clancy, Carolyn M. 1; Email Address: carolyn.clancyc@ahrq.hhs.gov; Affiliation: 1: Director, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 2006 Web Exclusives, Vol. 25, pw589; Subject Term: MEDICAL care; Subject Term: MEDICAL innovations; Subject Term: MEDICAL care costs; Subject Term: MEDICINE; Subject Term: MEDICAL informatics; Subject Term: COST effectiveness; Subject Term: MEDICAL technology; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1377/hlthaff.25.w589
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25072636&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joner, Michael
AU - Finn, Aloke V.
AU - Farb, Andrew
AU - Mont, Erik K.
AU - Kolodgie, Frank D.
AU - Ladich, Elena
AU - Kutys, Robert
AU - Skorija, Kristi
AU - Gold, Herman K.
AU - Virmani, Renu
T1 - Pathology of Drug-Eluting Stents in Humans: Delayed Healing and Late Thrombotic Risk
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2006/07/04/
VL - 48
IS - 1
M3 - Article
SP - 193
EP - 202
SN - 07351097
AB - Objectives: This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST). Background: Although DES reduce the need for repeat revascularization compared with bare-metal stents (BMS), data suggest the window of thrombotic risk for Cypher (Cordis Corp., Miami Lakes, Florida) and Taxus (Boston Scientific Corp., Natick, Massachusetts) DES extends far beyond that for BMS. Methods: From a registry of 40 autopsies of DES (68 stents), 23 DES cases of >30 days duration were compared with 25 matched autopsies of BMS implantation. Late stent thrombosis was defined as an acute thrombus within a stent >30 days old. Results: Of 23 patients with DES >30 days old, 14 had evidence of LST. Cypher and Taxus DES showed greater delayed healing characterized by persistent fibrin deposition (fibrin score 2.3 ± 1.1 vs. 0.9 ± 0.8, p = 0.0001) and poorer endothelialization (55.8 ± 26.5%) compared with BMS (89.8 ± 20.9, p = 0.0001). Moreover, DES with LST showed more delayed healing compared with patent DES. In 5 of 14 patients suffering LST, antiplatelet therapy had been withdrawn. Additional procedural and pathologic risk factors for LST were: 1) local hypersensitivity reaction; 2) ostial and/or bifurcation stenting; 3) malapposition/incomplete apposition; 4) restenosis; and 5) strut penetration into a necrotic core. Conclusions: The Cypher and Taxus DES result in delayed arterial healing when compared with BMS of similar implant duration. The cause of DES LST is multifactorial with delayed healing in combination with other clinical and procedural risk factors playing a role. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THROMBOSIS -- Risk factors
KW - SURGICAL stents
KW - RESEARCH
KW - CORONARY heart disease -- Treatment
KW - PATHOLOGY
KW - CARDIOLOGY -- Research
KW - bare-metal stents ( BMS )
KW - drug-eluting stents ( DES )
KW - Food and Drug Administration ( FDA )
KW - late stent thrombosis ( LST )
N1 - Accession Number: 21428781; Joner, Michael 1 Finn, Aloke V. 2 Farb, Andrew 3 Mont, Erik K. 4 Kolodgie, Frank D. 1 Ladich, Elena 1 Kutys, Robert 1 Skorija, Kristi 1 Gold, Herman K. 2 Virmani, Renu 1; Email Address: rvirmani@cvpath.org; Affiliation: 1: CVPath, International Registry of Pathology, Gaithersburg, Maryland 2: Cardiac Unit, Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts 3: Interventional Cardiology Devices Branch, U.S. Food and Drug Administration, Rockville, Maryland 4: Miami Dade County Medical Examiner Department, Heart Radiology, Miami, Florida; Source Info: Jul2006, Vol. 48 Issue 1, p193; Subject Term: THROMBOSIS -- Risk factors; Subject Term: SURGICAL stents; Subject Term: RESEARCH; Subject Term: CORONARY heart disease -- Treatment; Subject Term: PATHOLOGY; Subject Term: CARDIOLOGY -- Research; Author-Supplied Keyword: bare-metal stents ( BMS ); Author-Supplied Keyword: drug-eluting stents ( DES ); Author-Supplied Keyword: Food and Drug Administration ( FDA ); Author-Supplied Keyword: late stent thrombosis ( LST ); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jacc.2006.03.042
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21428781&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - O'Connell, Kathryn A.
AU - Wise, Robert P.
AU - Lozier, Jay N.
AU - Braun, M. Miles
T1 - Recombinant Factor Vlla and Thromboembolic Events.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/07/05/
VL - 296
IS - 1
M3 - Article
SP - 44
EP - 44
SN - 00987484
AB - A letter to the editor is presented in response to comments on the authors' article "Thromboembolic adverse events after use of recombinant human coagulation factor VIIa."
KW - LETTERS to the editor
KW - ENZYMES
KW - RESEARCH
N1 - Accession Number: 21437622; O'Connell, Kathryn A. 1; Email Address: kathryn.oconnell@hhs.fda.gov Wise, Robert P. 2 Lozier, Jay N. 3 Braun, M. Miles 2; Affiliation: 1: Center for Biologics Evaluation and Research Food and Drug Administration Rockville, Md 2: Division of Epidemiology, Center for Biologics Evaluation and Research Food and Drug Administration Rockville, Md 3: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research Food and Drug Administration Rockville, Md; Source Info: 7/5/2006, Vol. 296 Issue 1, p44; Subject Term: LETTERS to the editor; Subject Term: ENZYMES; Subject Term: RESEARCH; Number of Pages: 1/2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21437622&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Story, Alistair
AU - van Hest, Rob
AU - Hayward, Andrew
T1 - Tuberculosis and social exclusion.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2006/07/08/
VL - 333
IS - 7558
M3 - Article
SP - 57
EP - 58
SN - 09598146
AB - This article reports on the need to strengthen tuberculosis control among socially excluded groups. The author cites a recent persistent outbreak in London, England which involved over 220 drug resistant tuberculosis cases which disproportionately affected prisoners, problem drug users, and the homeless.
KW - TUBERCULOSIS
KW - PRISONERS
KW - HOMELESS persons
KW - DRUG abusers
KW - SOCIAL isolation
KW - REPORTING
KW - LONDON (England)
KW - ENGLAND
N1 - Accession Number: 21506599; Story, Alistair 1; Email Address: Alistair.Story@hpa.org.uk van Hest, Rob 2 Hayward, Andrew 3; Affiliation: 1: TB nurse and scientist Tuberculosis Section, Respiratory Disease Department, Centre for Infections, Health Protection Agency, London NW9 5EQ 2: consultant TB physician Tuberculosis Section, Department of Infectious Disease Control, Rotterdam Public Health Service, Rotterdam, 3011 EN, Netherlands 3: senior lecturer in infectious diseases University College London, Centre for Infectious Disease Epidemiology, London NW3 2PF; Source Info: 7/8/2006, Vol. 333 Issue 7558, p57; Subject Term: TUBERCULOSIS; Subject Term: PRISONERS; Subject Term: HOMELESS persons; Subject Term: DRUG abusers; Subject Term: SOCIAL isolation; Subject Term: REPORTING; Subject Term: LONDON (England); Subject Term: ENGLAND; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21506599&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Velazquez, Lydia
AU - Dallas, Scott
AU - Rose, Lisa
AU - Eva, Krista S.
AU - Saville, Rebecca
AU - Wang, Jialynn
AU - Bradley, Sean K.
AU - Bona, James D.
T1 - A PHS pharmacist team's response to Hurricane Katrina.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2006/07/15/
VL - 63
IS - 14
M3 - Article
SP - 1332
EP - 1335
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The challenges and victories that a team of Public Health Service (PHS) pharmacists experienced in establishing pharmacy operations at a federal medical station and conducting outreach missions are described. Summary. The Gulf coast of Mississippi and southeast Louisiana were struck on August 29, 2005, by Hurricane Katrina, which caused widespread infrastructure damage, flooding, and loss of life. A team of 70 officers, which included 8 pharmacists, arrived on September 3 and 4 to establish a 480- bed federal medical station in an aircraft hangar at the naval air station (NAS) in Meridian, Mississippi. Numerous challenges were encountered, including identifying a secure space for a pharmacy, determining how to manage the immediate shortage of medications, devising a dispensing system specific to controlled medications, handling personal medications brought in by patients, and maintaining adequate pharmacy staffing to provide for hospital needs. Two outreach efforts were also undertaken. The first was to assist the NAS pharmacy department, which was overwhelmed with nearly 800 Navy and Coast Guard personnel who were displaced to the Meridian NAS. The second outreach effort was to augment the staff at a local free clinic in Meridian, which needed help to set up their clinic so they could handle the influx of hurricane victims who were arriving daily. Conclusion. A team of PHS pharmacists established a pharmacy, provided pharmaceutical care, and conducted outreach programs to aid victims of Hurricane Katrina. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACISTS
KW - HURRICANE Katrina, 2005
KW - OUTREACH programs
KW - DISASTER relief
KW - UNITED States
KW - Controlled substances; Disasters; Dispensing; Drug distribution; Personnel
KW - pharmacy; Pharmaceutical care; Pharmaceutical services; Pharmacists; Public Health Service; Volunteers
N1 - Accession Number: 21469661; Velazquez, Lydia 1; Email Address: lydia.velazquez@fda.hhs.gov Dallas, Scott 2 Rose, Lisa 3 Eva, Krista S. 4 Saville, Rebecca 5 Wang, Jialynn 6 Bradley, Sean K. 7 Bona, James D. 8; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Division of Pharmaceutical Evaluation I 2: Division of Medication Errors and Technical Support, Office of Drug Safety, Food and Drug Administration (FDA), Silver Spring 3: Naytahwaush Clinic, Naytahwaush, MN 4: Indian Health Center, IHS, Pine Ridge 5: Division of Pathogens and Transplant Products 6: Division of Drug Marketing, Advertising, and Communications 7: Division of Oncology Products, FDA, Silver Spring 8: Office of Orphan Products Development, FDA, Rockville, MD; Source Info: 7/15/2006, Vol. 63 Issue 14, p1332; Subject Term: PHARMACISTS; Subject Term: HURRICANE Katrina, 2005; Subject Term: OUTREACH programs; Subject Term: DISASTER relief; Subject Term: UNITED States; Author-Supplied Keyword: Controlled substances; Disasters; Dispensing; Drug distribution; Personnel; Author-Supplied Keyword: pharmacy; Pharmaceutical care; Pharmaceutical services; Pharmacists; Public Health Service; Volunteers; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 624110 Child and Youth Services; Number of Pages: 4p; Document Type: Article
L3 - 10.2146/ajhp060020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21469661&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106369623
T1 - A PHS pharmacist team's response to Hurricane Katrina.
AU - Velazquez L
AU - Dallas S
AU - Rose L
AU - Evans KS
AU - Saville R
AU - Wang J
AU - Bradley SK
AU - Bona JD
Y1 - 2006/07/15/
N1 - Accession Number: 106369623. Language: English. Entry Date: 20061208. Revision Date: 20150711. Publication Type: Journal Article; anecdote. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Natural Disasters
KW - Pharmacy Service
KW - Systems Implementation
KW - Drug Administration -- Methods
KW - Louisiana
KW - Medication Errors -- Prevention and Control
KW - Narcotics
KW - Patient Care
KW - Pharmacists
KW - Pharmacy and Pharmacology -- Equipment and Supplies
KW - Systems Implementation -- Equipment and Supplies
KW - Systems Implementation -- Methods
KW - Teamwork
KW - Triage
KW - Workload
SP - 1332
EP - 1335
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 63
IS - 14
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - PURPOSE: The challenges and victories that a team of Public Health Service (PHS) pharmacists experienced in establishing pharmacy operations at a federal medical station and conducting outreach missions are described. SUMMARY: The Gulf coast of Mississippi and southeast Louisiana were struck on August 29, 2005, by Hurricane Katrina, which caused widespread infrastructure damage, flooding, and loss of life. A team of 70 officers, which included 8 pharmacists, arrived on September 3 and 4 to establish a 480-bed federal medical station in an aircraft hangar at the naval air station (NAS) in Meridian, Mississippi. Numerous challenges were encountered, including identifying a secure space for a pharmacy, determining how to manage the immediate shortage of medications, devising a dispensing system specific to controlled medications, handling personal medications brought in by patients, and maintaining adequate pharmacy staffing to provide for hospital needs. Two outreach efforts were also undertaken. The first was to assist the NAS pharmacy department, which was overwhelmed with nearly 800 Navy and Coast Guard personnel who were displaced to the Meridian NAS. The second outreach effort was to augment the staff at a local free clinic in Meridian, which needed help to set up their clinic so they could handle the influx of hurricane victims who were arriving daily. CONCLUSION: A team of PHS pharmacists established a pharmacy, provided pharmaceutical care, and conducted outreach programs to aid victims of Hurricane Katrina.
SN - 1079-2082
AD - Division of Medication Errors and Technical Support, Office of Drug Safety, Food and Drug Administration, 10903 New Hampshire Avenue, White Oak Building 221, Room 3633, Silver Spring, MD 20903; lydia.velazquez@fda.hhs.gov
U2 - PMID: 16809753.
DO - 10.2146/ajhp060020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106369623&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brezna, Barbara
AU - Kweon, Ohgew
AU - Stingley, Robin L.
AU - Freeman, James P.
AU - Khan, Ashraf A.
AU - Polek, Bystrik
AU - Jones, Richard C.
AU - Cerniglia, Carl E.
T1 - Molecular characterization of cytochrome P450 genes in the polycyclic aromatic hydrocarbon degrading Mycobacterium vanbaalenii PYR-1.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2006/07/15/
VL - 71
IS - 4
M3 - Article
SP - 522
EP - 532
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Mycobacterium vanbaalenii PYR-1 has the ability to degrade low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs). In addition to dioxygenases, cytochrome P450 monooxygenases have been implicated in PAH degradation. Three cytochrome P450 genes, cyp151 ( pipA), cyp150, and cyp51, were detected and amplified by polymerase chain reaction from M. vanbaalenii PYR-1. The complete sequence of these genes was determined. The translated putative proteins were ≥80% identical to other GenBank-listed mycobacterial CYP151, CYP150, and CYP51. Genes pipA and cyp150 were cloned, and the proteins partially expressed in Escherchia coli as soluble heme-containing cytochrome P450s that exhibited a characteristic peak at 450 nm in reduced carbon monoxide difference spectra. Monooxygenation metabolites of pyrene, dibenzothiophene, and 7-methylbenz[α]anthracene were detected in whole cell biotransformations, with E. coli expressing pipA or cyp150 when analyzed by gas chromatography/mass spectrometry. The cytochrome P450 inhibitor metyrapone strongly inhibited the S-oxidation of dibenzothiophene. Thirteen other Mycobacterium strains were screened for the presence of pipA, cyp150, and cyp51 genes, as well as the initial PAH dioxygenase ( nidA and nidB). The results indicated that many of the Mycobacterium spp. surveyed contain both monooxygenases and dioxygenases to degrade PAHs. Our results provide further evidence for the diverse enzymatic capability of Mycobacterium spp. to metabolize polycylic aromatic hydrocarbons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytochrome P-450
KW - Polycyclic aromatic hydrocarbons
KW - Microbial biotechnology
KW - Cytochromes
KW - Mycobacterium
N1 - Accession Number: 21540783; Brezna, Barbara 1,2; Kweon, Ohgew 1; Stingley, Robin L. 1; Freeman, James P. 3; Khan, Ashraf A. 1; Polek, Bystrik 2; Jones, Richard C. 4; Cerniglia, Carl E. 1; Email Address: ccerniglia@nctr.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovakia; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; 4: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Jul2006, Vol. 71 Issue 4, p522; Thesaurus Term: Cytochrome P-450; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Microbial biotechnology; Subject Term: Cytochromes; Subject Term: Mycobacterium; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 11p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00253-005-0190-8
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mei-Ling Chen
T1 - Ethnic or Racial Differences Revisited: Impact of Dosage Regimen and Dosage Form on Pharmacokinetics and Pharmacodynamics.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2006/07/15/
VL - 45
IS - 10
M3 - Article
SP - 957
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Ethnic or racial differences in pharmacokinetics and pharmacodynamics have been attributed to the distinctions in the genetic, physiological and pathological factors between ethnic/racial groups. These pharmacokinetic/pharmacodynamic differences are also known to be influenced by several extrinsic factors such as socioeconomic background, culture, diet and environment. However, it is noted that other factors related to dosage regimen and dosage form have largely been ignored or overlooked when conducting or analysing pharmacokinetic/pharmacodynamic studies in relation to ethnicity/race. Potential interactions can arise between the characteristics of ethnicity/race and a unique feature of dosage regimen or dosage form used in the study, which may partly account for the observed pharmacokinetic/pharmacodynamic differences between ethnic/racial groups.Ethnic/racial differences in pharmacokinetics/pharmacodynamics can occur from drug administration through a specific route that imparts distinct pattern of absorption, distribution, transport, metabolism or excretion. For example, racial differences in the first-pass metabolism of a drug following oral administration may not be relevant when the drug is applied to the skin. On the other hand, ethnic/racial difference in pharmacokinetics/pharmacodynamics can also happen via two different routes of drug delivery, with varying levels of dissimilarity between routes. For example, greater ethnic/racial differences were observed in oral clearance than in systemic clearance of some drugs, which might be explained by the pre-systemic factors involved in the oral administration as opposed to the intravenous administration. Similarly, changes in the dose frequency and/or duration may have profound impact on the ethnic/racial differences in pharmacokinetic/pharmacodynamic outcome. Saturation of enzymes, transporters or receptors at high drug concentrations is a possible reason for many observed ethnic/racial discrepancies between single- and multiple-dose regimens, or between low- and high-dose administrations. The presence of genetic polymorphism of enzymes and/or transporters can further complicate the analysis of pharmacokinetic/pharmacodynamic data in ethnic/racial populations. Even within the same dosage regimen, the use of different dosage forms may trigger significantly different pharmacokinetic/pharmacodynamic responses in various ethnic/racial groups, given that different dosage forms may exhibit different rates of drug release, may release the drug at different sites, and/or have different retention times at specific sites of the body. It is thus cautioned that the pharmacokinetic/pharmacodynamic data obtained from different ethnic/racial groups cannot be indiscriminately compared or combined for analysis if there is a lack of homogeneity in the apparent ‘extrinsic’ factors, including dosage regimen and dosage form. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - RACIAL differences
KW - DOSAGE forms of drugs
KW - ETHNIC groups
KW - PHARMACOLOGY
N1 - Accession Number: 22677772; Mei-Ling Chen 1; Email Address: meiling.chen@fda.hhs.gov; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2006, Vol. 45 Issue 10, p957; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Subject Term: RACIAL differences; Subject Term: DOSAGE forms of drugs; Subject Term: ETHNIC groups; Subject Term: PHARMACOLOGY; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bower, Jacquelyn J.
AU - Leonard, Stephen S.
AU - Chen, Fei
AU - Shi, Xianglin
T1 - As(III) transcriptionally activates the gadd45a gene via the formation of H2O2
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2006/07/15/
VL - 41
IS - 2
M3 - Article
SP - 285
EP - 294
SN - 08915849
AB - Abstract: Arsenic is a ubiquitous environmental contaminant associated with increased risks of human cancers of the skin, lung, bladder, and prostate. Intriguingly, it is also used to treat certain types of leukemia. It has recently been suggested that these paradoxic effects may be mediated by arsenic''s ability to simultaneously activate DNA damage and apoptotic and transformation pathways. Here, we investigate the effects of arsenic exposure on the induction of the growth arrest and DNA damage protein 45α (GADD45α), which is thought to play roles in apoptosis, DNA damage response, and cell cycle arrest. We found that arsenic transcriptionally activates the gadd45α promoter located in a 153-bp region between −234 and −81, relative to the transcriptional start site. In addition, this transcriptional induction was abrogated in the presence of H2O2 scavengers, suggesting a role for H2O2 in the transcriptional control of the gadd45a gene through a Fenton-like free radical mechanism. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARSENIC
KW - CANCER -- Risk factors
KW - DNA damage
KW - APOPTOSIS
KW - activator protein 1 ( AP-1 )
KW - Arsenic
KW - Arsenite
KW - arsenite ( As(III) )
KW - As(III)
KW - BEAS-2B
KW - Cell cycle control
KW - complementary DNA ( cDNA )
KW - deoxyribonucleic acid ( DNA )
KW - diphenyl-2-picrylhydrazyl ( DPPH )
KW - early growth response gene 1 ( Egr-1 )
KW - early growth response gene 2 ( Egr-2 )
KW - early growth response gene 3 ( Egr-3 )
KW - electron spin resonance ( ESR )
KW - enhanced green fluorescence protein ( EGFP )
KW - extracellular signal-regulated kinase ( ERK )
KW - forkhead response elements ( FHRE )
KW - GADD45α
KW - gap 1/synthesis phase ( G1/S )
KW - gap 2/mitosis phase ( G2/M )
KW - Gauss ( G )
KW - glutathione peroxidase 1 ( GPx1 )
KW - glyceraldehyde-3-phosphate dehydrogenase ( GAPDH )
KW - growth arrest and DNA damage-inducible protein 153 ( gadd153 )
KW - growth arrest and DNA damage-inducible protein 45 alpha ( GADD45α )
KW - hydroxyl radical ( ·OH )
KW - ionizing radiation ( IR )
KW - messenger ribonucleic acid ( mRNA )
KW - metal binding factor 1 ( MBF-1 )
KW - methylmethane sulfonate ( MMS )
KW - nuclear factor κB ( NF-κB )
KW - phosphate-buffered saline ( PBS )
KW - Polyvinylidene fluoride ( PVDF )
KW - quantitative real-time polymerase chain reaction ( qRT-PCR )
KW - reactive oxygen species ( ROS )
KW - ribonucleic acid ( RNA )
KW - ribosomal ribonucleic acid ( rRNA )
KW - standard error of the mean ( SEM )
KW - superoxide dismutase 1 ( SOD1 )
KW - superoxide radical ( O2 ·- )
KW - threshold cycle ( Ct )
KW - transcriptional start site ( tss )
KW - Tris-buffered saline ( TBS–Tween )
KW - ultraviolet irradiation ( UV )
KW - yeast activator protein 1 ( Yap1 )
N1 - Accession Number: 21428368; Bower, Jacquelyn J. 1,2 Leonard, Stephen S. 1,2 Chen, Fei 1,2 Shi, Xianglin 1,2; Email Address: xshi@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA; Source Info: Jul2006, Vol. 41 Issue 2, p285; Subject Term: ARSENIC; Subject Term: CANCER -- Risk factors; Subject Term: DNA damage; Subject Term: APOPTOSIS; Author-Supplied Keyword: activator protein 1 ( AP-1 ); Author-Supplied Keyword: Arsenic; Author-Supplied Keyword: Arsenite; Author-Supplied Keyword: arsenite ( As(III) ); Author-Supplied Keyword: As(III); Author-Supplied Keyword: BEAS-2B; Author-Supplied Keyword: Cell cycle control; Author-Supplied Keyword: complementary DNA ( cDNA ); Author-Supplied Keyword: deoxyribonucleic acid ( DNA ); Author-Supplied Keyword: diphenyl-2-picrylhydrazyl ( DPPH ); Author-Supplied Keyword: early growth response gene 1 ( Egr-1 ); Author-Supplied Keyword: early growth response gene 2 ( Egr-2 ); Author-Supplied Keyword: early growth response gene 3 ( Egr-3 ); Author-Supplied Keyword: electron spin resonance ( ESR ); Author-Supplied Keyword: enhanced green fluorescence protein ( EGFP ); Author-Supplied Keyword: extracellular signal-regulated kinase ( ERK ); Author-Supplied Keyword: forkhead response elements ( FHRE ); Author-Supplied Keyword: GADD45α; Author-Supplied Keyword: gap 1/synthesis phase ( G1/S ); Author-Supplied Keyword: gap 2/mitosis phase ( G2/M ); Author-Supplied Keyword: Gauss ( G ); Author-Supplied Keyword: glutathione peroxidase 1 ( GPx1 ); Author-Supplied Keyword: glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ); Author-Supplied Keyword: growth arrest and DNA damage-inducible protein 153 ( gadd153 ); Author-Supplied Keyword: growth arrest and DNA damage-inducible protein 45 alpha ( GADD45α ); Author-Supplied Keyword: hydroxyl radical ( ·OH ); Author-Supplied Keyword: ionizing radiation ( IR ); Author-Supplied Keyword: messenger ribonucleic acid ( mRNA ); Author-Supplied Keyword: metal binding factor 1 ( MBF-1 ); Author-Supplied Keyword: methylmethane sulfonate ( MMS ); Author-Supplied Keyword: nuclear factor κB ( NF-κB ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: Polyvinylidene fluoride ( PVDF ); Author-Supplied Keyword: quantitative real-time polymerase chain reaction ( qRT-PCR ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: ribonucleic acid ( RNA ); Author-Supplied Keyword: ribosomal ribonucleic acid ( rRNA ); Author-Supplied Keyword: standard error of the mean ( SEM ); Author-Supplied Keyword: superoxide dismutase 1 ( SOD1 ); Author-Supplied Keyword: superoxide radical ( O2 ·- ); Author-Supplied Keyword: threshold cycle ( Ct ); Author-Supplied Keyword: transcriptional start site ( tss ); Author-Supplied Keyword: Tris-buffered saline ( TBS–Tween ); Author-Supplied Keyword: ultraviolet irradiation ( UV ); Author-Supplied Keyword: yeast activator protein 1 ( Yap1 ); NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2006.04.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roach, Mack
AU - Hanks, Gerald
AU - Thames, Howard
AU - Schellhammer, Paul
AU - Shipley, William U.
AU - Sokol, Gerald H.
AU - Sandler, Howard
T1 - Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
Y1 - 2006/07/15/
VL - 65
IS - 4
M3 - Article
SP - 965
EP - 974
SN - 03603016
AB - In 1996 the American Society for Therapeutic Radiology and Oncology (ASTRO) sponsored a Consensus Conference to establish a definition of biochemical failure after external beam radiotherapy (EBRT). The ASTRO definition defined prostate specific antigen (PSA) failure as occurring after three consecutive PSA rises after a nadir with the date of failure as the point halfway between the nadir date and the first rise or any rise great enough to provoke initiation of therapy. This definition was not linked to clinical progression or survival; it performed poorly in patients undergoing hormonal therapy (HT), and backdating biased the Kaplan-Meier estimates of event-free survival. A second Consensus Conference was sponsored by ASTRO and the Radiation Therapy Oncology Group in Phoenix, Arizona, on January 21, 2005, to revise the ASTRO definition. The panel recommended: (1) a rise by 2 ng/mL or more above the nadir PSA be considered the standard definition for biochemical failure after EBRT with or without HT; (2) the date of failure be determined “at call” (not backdated). They recommended that investigators be allowed to use the ASTRO Consensus Definition after EBRT alone (no hormonal therapy) with strict adherence to guidelines as to “adequate follow-up.” To avoid the artifacts resulting from short follow-up, the reported date of control should be listed as 2 years short of the median follow-up. For example, if the median follow-up is 5 years, control rates at 3 years should be cited. Retaining a strict version of the ASTRO definition would allow comparisons with a large existing body of literature. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOLOGY
KW - MEDICAL radiology
KW - RADIOTHERAPY
KW - HEAT -- Radiation & absorption
KW - Biochemical recurrence
KW - Prostate cancer
KW - PSA failure
KW - Radiotherapy
N1 - Accession Number: 21338169; Roach, Mack 1; Email Address: roach@radonc17.ucsf.edu Hanks, Gerald 2 Thames, Howard 3 Schellhammer, Paul 4 Shipley, William U. 5 Sokol, Gerald H. 6 Sandler, Howard 7; Affiliation: 1: Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 2: Department of Radiation Oncology, Fox Chase Comprehensive Cancer Center, Philadelphia, PA 3: Department of Biostatistics and Applied Mathematics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 4: Department of Urology, Eastern Virginia Medical School, Norfolk, VA 5: Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 6: U.S. Food and Drug Administration, Rockville, MD 7: Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA; Source Info: Jul2006, Vol. 65 Issue 4, p965; Subject Term: ONCOLOGY; Subject Term: MEDICAL radiology; Subject Term: RADIOTHERAPY; Subject Term: HEAT -- Radiation & absorption; Author-Supplied Keyword: Biochemical recurrence; Author-Supplied Keyword: Prostate cancer; Author-Supplied Keyword: PSA failure; Author-Supplied Keyword: Radiotherapy; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ijrobp.2006.04.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Minton, Allen P.
T1 - How can biochemical reactions within cells differ from those in test tubes?
JO - Journal of Cell Science
JF - Journal of Cell Science
Y1 - 2006/07/15/
VL - 119
IS - 14
M3 - Article
SP - 2
EP - 2
SN - 00219533
AB - Nonspecific interactions between individual macro-molecules and their immediate surroundings ('background interactions') within a medium as heterogeneous and highly volume occupied as the interior of a living cell can greatly influence the equilibria and rates of reactions in which they participate. Background interactions may be either repulsive, leading to preferential size-and-shape-dependent exclusion from highly volume-occupied elements of volume, or attractive, leading to nonspecific associations or adsorption. Nonspecific interactions with different constituents of the cellular interior lead to three classes of phenomena: macromolecular crowding, confinement and adsorption. Theory and experiment have established that predominantly repulsive background interactions tend to enhance the rate and extent of macromolecular associations in solution, whereas predominately attractive background interactions tend to enhance the tendency of macromolecules to associate on adsorbing surfaces. Greater than order-of-magnitude increases in association rate and equilibrium constants attributable to background interactions have been observed in simulated and actual intracellular environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Science is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROMOLECULES
KW - BIOCHEMICAL genetics
KW - MOLECULAR genetics
KW - SUPRAMOLECULAR chemistry
KW - MOLECULES
KW - Macromolecular adsorption
KW - Macromolecular confinement
KW - Macromolecular crowding
KW - Protein associations
KW - Protein folding
KW - Protein stability
N1 - Accession Number: 21715797; Minton, Allen P. 1; Email Address: minton@helix.nih.gov; Affiliation: 1: Section on Physical Biochemistry, Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA; Source Info: 7/15/2006, Vol. 119 Issue 14, p2; Subject Term: MACROMOLECULES; Subject Term: BIOCHEMICAL genetics; Subject Term: MOLECULAR genetics; Subject Term: SUPRAMOLECULAR chemistry; Subject Term: MOLECULES; Author-Supplied Keyword: Macromolecular adsorption; Author-Supplied Keyword: Macromolecular confinement; Author-Supplied Keyword: Macromolecular crowding; Author-Supplied Keyword: Protein associations; Author-Supplied Keyword: Protein folding; Author-Supplied Keyword: Protein stability; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keller, J.E.
T1 - Recovery from botulinum neurotoxin poisoning in vivo
JO - Neuroscience
JF - Neuroscience
Y1 - 2006/07/15/
VL - 139
IS - 2
M3 - Article
SP - 629
EP - 637
SN - 03064522
AB - Abstract: Botulinum neurotoxins cause the disease botulism, which is characterized by prolonged muscle paralysis. In contrast, injections of low doses of purified botulinum neurotoxins do not cause systemic illness but produce localized muscle paralysis that is beneficial for treating several human medical disorders involving uncontrollable muscle contraction. Optimizing the therapeutic efficacy while diminishing adverse reactions requires precise knowledge of toxin potency as well as a clear understanding of how each toxin causes disease. A novel in vivo mouse assay has been used to correlate toxin dosage with the duration of muscle paralysis. Voluntary running activity performed by mice was proportional to the amount of toxin injected into the hind limbs and the subsequent rate of recovery over the ensuing days or weeks was a function of botulinum neurotoxin serotype A or B concentration. Botulinum neurotoxin A produced longer paralysis than botulinum neurotoxin B consistent with human observations. A third serotype, botulinum neurotoxin E, had the shortest duration of action, but unlike the other two toxins, dosage did not influence recovery time. Botulinum neurotoxin A recovery appeared biphasic with the initial phase about two-fold faster than the final phase. Over four weeks, muscle activity had gradually improved following the highest botulinum neurotoxin A dose, reaching about half of the normal running activity. Lower botulinum neurotoxin A doses led to incrementally faster and complete recovery. Persistence of maximum paralysis was exponentially related to botulinum neurotoxin A dosage, with a doubling of the paralysis time occurring with every 25% increase of the toxin concentration. In contrast, the rate of recovery from botulinum neurotoxin B was monophasic relative to toxin dosage and the duration of maximum paralysis was linear relative to dosage. Combinations of botulinum neurotoxin A and B and botulinum neurotoxin A and E were tested and shown to exacerbate paralysis compared with individually administered serotypes. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BOTULINUM toxin
KW - NEUROTOXIC agents
KW - MUSCLE contraction
KW - MUSCLES -- Motility
KW - botulinum neurotoxin
KW - botulinum neurotoxin ( BoNT )
KW - botulism
KW - dose that will kill 50% of mice injected within a four day period ( LD50 )
KW - extensor digitorum brevis ( EDB )
KW - extensor digitorum longus ( EDL )
KW - paralysis
KW - potency assay
KW - recovery
N1 - Accession Number: 20405956; Keller, J.E. 1; Email Address: james.keller@fda.hhs.gov; Affiliation: 1: Laboratory of Bacterial Toxins, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, HFM 434, Room 122, Bethesda, MD 20892, USA; Source Info: Jul2006, Vol. 139 Issue 2, p629; Subject Term: BOTULINUM toxin; Subject Term: NEUROTOXIC agents; Subject Term: MUSCLE contraction; Subject Term: MUSCLES -- Motility; Author-Supplied Keyword: botulinum neurotoxin; Author-Supplied Keyword: botulinum neurotoxin ( BoNT ); Author-Supplied Keyword: botulism; Author-Supplied Keyword: dose that will kill 50% of mice injected within a four day period ( LD50 ); Author-Supplied Keyword: extensor digitorum brevis ( EDB ); Author-Supplied Keyword: extensor digitorum longus ( EDL ); Author-Supplied Keyword: paralysis; Author-Supplied Keyword: potency assay; Author-Supplied Keyword: recovery; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.neuroscience.2005.12.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salierno, J.D.
AU - Snyder, N.S.
AU - Murphy, A.Z.
AU - Poli, M.
AU - Hall, S.
AU - Baden, D.
AU - Kane, A.S.
T1 - Harmful algal bloom toxins alter c-Fos protein expression in the brain of killifish, Fundulus heteroclitus
JO - Aquatic Toxicology
JF - Aquatic Toxicology
Y1 - 2006/07/20/
VL - 78
IS - 4
M3 - Article
SP - 350
EP - 357
SN - 0166445X
AB - Abstract: The immediate early gene c-fos, and its protein product c-Fos, are known to be induced in neurons of mammals and fish as a result of neuronal stimulation. The purpose of this study was to quantitatively examine CNS alterations in killifish, Fundulus heteroclitus, in relation to harmful algal bloom (HAB) toxin exposure. c-Fos expression was visualized using immunocytochemistry in the brains of killifish exposed to the excitatory neurotoxins domoic acid (DA) and brevetoxin (PbTx-2), and a paralytic neurotoxin, saxitoxin (STX), released from HABs. In addition, a simulated transport stress experiment was conducted to investigate effects of physical stress on c-Fos induction. Groups of fish were exposed to the different stress agents, brain sections were processed for c-Fos staining, and expression was quantified by brain region. Fish exposed to DA, STX, and transport stress displayed significant alterations in neuronal c-Fos expression when compared to control fish (p ≤0.05). DA, PbTx-2, and transport stress increased c-Fos expression in the optic tecta regions of the brain, whereas STX significantly decreased expression. This is the first study to quantify c-Fos protein expression in fish exposed to HAB toxins. General alterations in brain activity, as well as knowledge of specific regions within the brain activated in association with HABs or other stressors, provides valuable insights into the neural control of fish behavior as well as sublethal effects of specific stressors in the CNS. [Copyright &y& Elsevier]
AB - Copyright of Aquatic Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Neurotoxic agents
KW - Algal blooms
KW - Microalgae
KW - Marine toxins
KW - Brevetoxin
KW - c-Fos
KW - Domoic acid
KW - Fish
KW - Fundulus heteroclitus
KW - Saxitoxin
N1 - Accession Number: 21337735; Salierno, J.D. 1; Snyder, N.S. 2; Murphy, A.Z. 3; Poli, M. 4; Hall, S. 5; Baden, D. 6; Kane, A.S. 1,7; Email Address: akane@umaryland.edu; Affiliations: 1: Aquatic Pathobiology Center, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; 2: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; 3: Department of Biology, Georgia State University, Atlanta, GA 30303, USA; 4: US Army Medical Research Institute of Infectious Diseases, Integrated Toxicology Division, Fort Detrick, USA; 5: US Food and Drug Administration, Office of Seafood, Beltsville Research Facility, Laurel, MD 20708, USA; 6: Center for Marine Science Research, University of North Carolina Wilmington, Wilmington, NC 28409, USA; 7: Aquatic Pathobiology Center, Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA; Issue Info: Jul2006, Vol. 78 Issue 4, p350; Thesaurus Term: Neurotoxic agents; Thesaurus Term: Algal blooms; Thesaurus Term: Microalgae; Thesaurus Term: Marine toxins; Author-Supplied Keyword: Brevetoxin; Author-Supplied Keyword: c-Fos; Author-Supplied Keyword: Domoic acid; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Fundulus heteroclitus; Author-Supplied Keyword: Saxitoxin; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.aquatox.2006.04.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21337735&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Koturbash, I.
AU - Rugo, R. E.
AU - Hendricks, C. A.
AU - Loree, J.
AU - Thibault, B.
AU - Kutanzi, K.
AU - Pogribny, I.
AU - Yanch, J. C.
AU - Engelward, B. P.
AU - Kovalchuk, O.
T1 - Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.
JO - Oncogene
JF - Oncogene
Y1 - 2006/07/20/
VL - 25
IS - 31
M3 - Article
SP - 4267
EP - 4275
PB - Nature Publishing Group
SN - 09509232
AB - Irradiated cells induce chromosomal instability in unirradiated bystander cells in vitro. Although bystander effects are thought to be linked to radiation-induced secondary cancers, almost no studies have evaluated bystander effects in vivo. Furthermore, it has been proposed that epigenetic changes mediate bystander effects, but few studies have evaluated epigenetic factors in bystander tissues in vivo. Here, we describe studies in which mice were unilaterally exposed to X-irradiation and the levels of DNA damage, DNA methylation and protein expression were evaluated in irradiated and bystander cutaneous tissue. The data show that X-ray exposure to one side of the animal body induces DNA strand breaks and causes an increase in the levels of Rad51 in unexposed bystander tissue. In terms of epigenetic changes, unilateral radiation suppresses global methylation in directly irradiated tissue, but not in bystander tissue at given time-points studied. Intriguingly, however, we observed a significant reduction in the levels of the de novo DNA methyltransferases DNMT3a and 3b and a concurrent increase in the levels of the maintenance DNA methyltransferase DNMT1 in bystander tissues. Furthermore, the levels of two methyl-binding proteins known to be involved in transcriptional silencing, MeCP2 and MBD2, were also increased in bystander tissue. Together, these results show that irradiation induces DNA damage in bystander tissue more than a centimeter away from directly irradiated tissues, and suggests that epigenetic transcriptional regulation may be involved in the etiology of radiation-induced bystander effects.Oncogene (2006) 25, 4267–4275. doi:10.1038/sj.onc.1209467; published online 13 March 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IRRADIATION
KW - DNA damage
KW - CANCER
KW - METHYLTRANSFERASES
KW - DNA
KW - BIOCHEMICAL genetics
KW - bystander effect
KW - epigenetics
KW - radiation
N1 - Accession Number: 21656004; Koturbash, I. 1 Rugo, R. E. 2 Hendricks, C. A. 2 Loree, J. 1 Thibault, B. 1 Kutanzi, K. 1 Pogribny, I. 3 Yanch, J. C. 4 Engelward, B. P. 2 Kovalchuk, O. 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Alberta, Canada 2: Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA 4: Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Source Info: 7/20/2006, Vol. 25 Issue 31, p4267; Subject Term: IRRADIATION; Subject Term: DNA damage; Subject Term: CANCER; Subject Term: METHYLTRANSFERASES; Subject Term: DNA; Subject Term: BIOCHEMICAL genetics; Author-Supplied Keyword: bystander effect; Author-Supplied Keyword: epigenetics; Author-Supplied Keyword: radiation; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 9p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1038/sj.onc.1209467
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Herrmann, John E.
AU - Wang, Shixia
AU - Zhang, Chuanyou
AU - Panchal, Rekha G.
AU - Bavari, Sina
AU - Lyons, C. Rick
AU - Lovchik, Julie A.
AU - Golding, Basil
AU - Shiloach, Joseph
AU - Lu, Shan
T1 - Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization
JO - Vaccine
JF - Vaccine
Y1 - 2006/07/26/
VL - 24
IS - 31/32
M3 - Article
SP - 5872
EP - 5880
SN - 0264410X
AB - Abstract: Because of the high failure rate of antibiotic treatment in patients with anthrax there is a need for additional therapies such as passive immunization with therapeutic antibodies. In this study, we used codon-optimized plasmid DNAs (DNA vaccines) encoding Bacillus anthracis protective antigen (PA) to immunize rabbits for producing anti-anthrax antibodies for use in passive immunotherapy. The antisera generated with these DNA vaccines were of high titer as measured by ELISA. The antisera were also able to protect J774 macrophage cells by neutralizing the cytotoxic effect of exogenously added anthrax lethal toxin, and of the toxin released by B. anthracis (Sterne strain) spores following infection. In addition, the antisera passively protected mice against pulmonary challenge with an approximate 50 LD50 dose of B. anthracis (Sterne strain) spores. The protection in mice was obtained when the antiserum was given 1h before or 1h after challenge. We further demonstrated that IgG and F(ab′)2 components purified from anti-PA rabbit hyperimmune sera retained similar levels of neutralizing activities against both exogenously added B. anthracis lethal toxin and toxin produced by B. anthracis (Sterne strain) spores. The high titer antisera we produced will enable an immunization strategy to supplement antibiotic therapy for improving the survival of patients with anthrax. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - Immune serums
KW - Preventive medicine
KW - Anthrax
KW - DNA vaccine
KW - Immunotherapy
KW - Passive immunity
KW - Protective antibodies
N1 - Accession Number: 21430262; Herrmann, John E. 1; Email Address: ASI@AbScience.com; Wang, Shixia 2; Zhang, Chuanyou 1; Panchal, Rekha G. 3; Bavari, Sina 4; Lyons, C. Rick 5; Lovchik, Julie A. 5; Golding, Basil 6; Shiloach, Joseph 7; Lu, Shan 1; Affiliations: 1: Antibody Science, Inc., 80 Webster Street, Worcester, MA 01603, USA; 2: Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; 3: Target Structure Based Drug Discovery Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MA 21702, USA; 4: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21705, USA; 5: Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA; 6: Division of Hematology, Office of Blood Research and Review, Food and Drug Administration, Rockville, MD 20852, USA; 7: Biotechnology Unit, National Institute of Digestive, Diabetes, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Issue Info: Jul2006, Vol. 24 Issue 31/32, p5872; Thesaurus Term: Nucleic acids; Subject Term: Immune serums; Subject Term: Preventive medicine; Subject Term: Anthrax; Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: Immunotherapy; Author-Supplied Keyword: Passive immunity; Author-Supplied Keyword: Protective antibodies; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.04.065
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoashi, Toshihiko
AU - Muller, Jacqueline
AU - Vieira, Wilfred D.
AU - Rouzaud, Francois
AU - Kikuchi, Kanako
AU - Tamaki, Kunihiko
AU - Hearing, Vincent J.
T1 - The Repeat Domain of the Melanosomal Matrix Protein PMEL17/GP100 Is Required for the Formation of Organellar Fibers.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/07/28/
VL - 281
IS - 30
M3 - Article
SP - 21198
EP - 21208
SN - 00219258
AB - Over 125 pigmentation-related genes have been identified to date. Of those, PMEL17/GP100 has been widely studied as a melanoma-specific antigen as well as a protein required for the formation of fibrils in melanosomes. PMEL17 is synthesized, glycosylated, processed, and delivered to melanosomes, allowing them to mature from amorphous round vesicles to elongated fibrillar structures. In contrast to other melanosomal proteins such as TYR and TYRP1, the processing and sorting of PMEL17 is highly complex. Monoclonal antibody HMB45 is commonly used for melanoma detection, but has the added advantage that it specifically reacts with sialylated PMEL17 in the fibrillar matrix in melanosomes. In this study, we generated mutant forms of PMEL17 to clarify the subdomain of PMEL17 required for formation of the fibrillar matrix, a process critical to pigmentation. The internal proline/serine/threonine-rich repeat domain (called the RPT domain) of PMEL17 undergoes variable proteolytic cleavage. Deletion of the RPT domain abolished its recognition by HMB45 and its capacity to form fibrils. Truncation of the C-terminal domain did not significantly affect the processing or trafficking of PMEL17, but, in contrast, deletion of the N-terminal domain abrogated both. We conclude that the RPT domain is essential for its function in generating the fibrillar matrix of melanosomes and that the luminal domain is necessary for its correct processing and trafficking to those organelles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - MONOCLONAL antibodies
KW - IMMUNOGLOBULINS
KW - COATED vesicles
KW - CELL organelles
KW - HUMAN skin color
N1 - Accession Number: 21988101; Hoashi, Toshihiko 1,2; Email Address: thoashi-tky@umin.ac.jp Muller, Jacqueline 3 Vieira, Wilfred D. 1 Rouzaud, Francois 1 Kikuchi, Kanako 2 Tamaki, Kunihiko 2 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892-4256 2: Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan 3: Division of Viral Products, Food and Drug Administration, Rockville, Maryland 20852; Source Info: 7/28/2006, Vol. 281 Issue 30, p21198; Subject Term: PROTEINS; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNOGLOBULINS; Subject Term: COATED vesicles; Subject Term: CELL organelles; Subject Term: HUMAN skin color; Number of Pages: 11p; Illustrations: 6 Diagrams; Document Type: Article
L3 - 10.1074/jbc.M601643200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mahoney, Christine M.
AU - Patwardhan, Dinesh V.
AU - Ken McDermott, M.
T1 - Characterization of drug-eluting stent (DES) materials with cluster secondary ion mass spectrometry (SIMS)
JO - Applied Surface Science
JF - Applied Surface Science
Y1 - 2006/07/30/
VL - 252
IS - 19
M3 - Article
SP - 6554
EP - 6557
SN - 01694332
AB - Abstract: Secondary ion mass spectrometry (SIMS) employing an SF5+ polyatomic primary ion source was utilized to analyze several materials commonly used in drug-eluting stents (DES). Poly(ethylene-co-vinyl acetate) (PEVA), poly(lactic-co-glycolic acid) (PLGA) and various poly(urethanes) were successfully depth profiled using SF5+ bombardment. The resultant molecular depth profiles obtained from these polymeric films showed very little degradation in molecular signal as a function of increasing SF5+ primary ion dose when experiments were performed at low temperatures (signal was maintained for doses up to ∼5×1015 ions/cm2). Temperature was determined to be an important parameter in both the success of the depth profiles and the mass spectral analysis of the polymers. In addition to the pristine polymer films, paclitaxel (drug released in Taxus™ stent) containing PLGA films were also characterized, where it was confirmed that both drug and polymer signals could be monitored as a function of depth at lower paclitaxel concentrations (10wt%). [Copyright &y& Elsevier]
AB - Copyright of Applied Surface Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SECONDARY ion mass spectrometry
KW - ION sources
KW - ION bombardment
KW - MONOMOLECULAR films
KW - Biomaterials
KW - Cluster
KW - Coronary
KW - Depth profile
KW - DES
KW - Drug-eluting
KW - Paclitaxel
KW - Polymers
KW - SF5 +
KW - SIMS
KW - Stents
KW - Temperature
N1 - Accession Number: 22009574; Mahoney, Christine M. 1; Email Address: christine.mahoney@nist.gov Patwardhan, Dinesh V. 2 Ken McDermott, M. 2; Affiliation: 1: National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 8371, Gaithersburg, MD 20899-8113, USA 2: Center for Devices and Radiological Health, Food and Drug Administration, 12725 Twinbrook Parkway, HFZ-150, Rockville, MD 20852, USA; Source Info: Jul2006, Vol. 252 Issue 19, p6554; Subject Term: SECONDARY ion mass spectrometry; Subject Term: ION sources; Subject Term: ION bombardment; Subject Term: MONOMOLECULAR films; Author-Supplied Keyword: Biomaterials; Author-Supplied Keyword: Cluster; Author-Supplied Keyword: Coronary; Author-Supplied Keyword: Depth profile; Author-Supplied Keyword: DES; Author-Supplied Keyword: Drug-eluting; Author-Supplied Keyword: Paclitaxel; Author-Supplied Keyword: Polymers; Author-Supplied Keyword: SF5 +; Author-Supplied Keyword: SIMS; Author-Supplied Keyword: Stents; Author-Supplied Keyword: Temperature; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.apsusc.2006.02.107
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Caruso, Claire C.
AU - Condon, Marian E.
T1 - Night Shifts and Fatigue.
JO - American Journal of Nursing
JF - American Journal of Nursing
Y1 - 2006/08//
VL - 106
IS - 8
M3 - Article
SP - 88
EP - 88
SN - 0002936X
AB - The article focuses on the effects of night-shift work on the health and safety of health care workers. Researchers have found potentially negative aspects of such work. Such shifts create potential risks which stem from disturbances of sleep, circadian rhythms, and social life caused by having to sleep during the day. However, some workers experience benefits such as incentive pay and reduced volume of activities.
KW - NIGHT work
KW - MEDICAL personnel
KW - MEDICAL care
KW - CIRCADIAN rhythms
KW - INCENTIVES in industry
N1 - Accession Number: 21928661; Caruso, Claire C. 1 Condon, Marian E. 2; Affiliation: 1: Research Health Scientist, National Institute for Occupational Safety and Health (NIOSH) 2: Senior Staff Specialist, ANA's Center for Occupational and Environmental Health; Source Info: Aug2006, Vol. 106 Issue 8, p88; Subject Term: NIGHT work; Subject Term: MEDICAL personnel; Subject Term: MEDICAL care; Subject Term: CIRCADIAN rhythms; Subject Term: INCENTIVES in industry; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106337716
T1 - Health & safety. Night shifts and fatigue: coping skills for the working nurse.
AU - Caruso CC
AU - Condon ME
Y1 - 2006/08//
N1 - Accession Number: 106337716. Language: English. Entry Date: 20060922. Revision Date: 20150711. Publication Type: Journal Article; questions and answers. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Coping
KW - Fatigue -- Prevention and Control
KW - Nurses
KW - Occupational Health
KW - Shift Workers
KW - Shiftwork
SP - 88
EP - 88
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 106
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0002-936X
AD - Research Health Scientist, National Institute for Occupational Safety and Health
U2 - PMID: 16905944.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Qingdong Ke
AU - Jingxia Li
AU - Jin Ding
AU - Min Ding
AU - Liying Wang
AU - Bingci Liu
AU - Costa, Max
AU - Chuanshu Huang
T1 - Essential role of ROS-mediated NFAT activation in TNF-α induction by crystalline silica exposure.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2006/08//
VL - 35
IS - 2
M3 - Article
SP - L257
EP - L264
SN - 10400605
AB - Occupational exposure to crystalline silica has been associated with progressive pulmonary silicosis and lung cancer, but the underlying molecular mechanisms are not well understood. Previous studies have shown that crystalline silica exposure can generate reactive oxygen species (ROS) and induce the expression of the inflammatory cytokine tumor necrosis factor-α (TNF-α) in cells. TNF-α is believed to be critical in the development of silica-related diseases. Thus it will be of significance to understand the mechanisms of TNF-α induction by silica exposure. Given the fact that the transcription factor nuclear factor of activated T cells (NFAT) plays an important role in the regulation of TNF-α and can also be activated by ROS, in this study we investigated the potential role of ROS in silica-induced NFAT activity as well as TNF-α expression in C141 cells. The results showed that exposure of cells to silica led to NFAT transactivation and TNF-α induction, where superoxide anion radical (O2-·), but not H2O2, was involved. The knockdown of NFAT3 by its specific small interfering RNA significantly attenuated the silica-induced TNF-α transcription. This study demonstrated that silica was able to activate NFAT in an O2-·-dependent manner, which was required for TNF-α induction. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - LUNGS -- Cancer
KW - TUMOR necrosis factor
KW - SMALL interfering RNA
KW - OXYGEN
KW - SILICOSIS
KW - nuclear factor of activated T cells
KW - reactive oxygen species
KW - signal transduction
KW - silica
KW - tumor necrosis factor-α
N1 - Accession Number: 21787626; Qingdong Ke 1 Jingxia Li 1 Jin Ding 1 Min Ding 2 Liying Wang 2 Bingci Liu 3 Costa, Max 1 Chuanshu Huang 1; Email Address: chuanshu@env.med.nyu.edu; Affiliation: 1: Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: National Institute of Occupational Health and Poisons Control, Chinese Center for Diseases Control and Prevention, Beijing, China; Source Info: Aug2006, Vol. 35 Issue 2, pL257; Subject Term: SILICA; Subject Term: LUNGS -- Cancer; Subject Term: TUMOR necrosis factor; Subject Term: SMALL interfering RNA; Subject Term: OXYGEN; Subject Term: SILICOSIS; Author-Supplied Keyword: nuclear factor of activated T cells; Author-Supplied Keyword: reactive oxygen species; Author-Supplied Keyword: signal transduction; Author-Supplied Keyword: silica; Author-Supplied Keyword: tumor necrosis factor-α; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article
L3 - 10.1152/ajplung.00007.2005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Korrapati, Midhun C.
AU - Chilakapati, Jaya
AU - Lock, Edward A.
AU - Latendresse, John R.
AU - Warbritton, Alan
AU - Mehendale, Harihara M.
T1 - Preplaced cell division: a critical mechanism of autoprotection against S-1 ,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
JO - American Journal of Physiology: Renal Physiology
JF - American Journal of Physiology: Renal Physiology
Y1 - 2006/08//
VL - 60
IS - 2
M3 - Article
SP - F439
EP - F455
SN - 1931857X
AB - Previous studies have shown that renal injury initiated by a lethal dose of S-1,2-dichlorovinyl-L-cysteine (DCVC) progresses due to inhibition of cell division and hence renal repair, leading to acute renal failure (ARF) and death in mice. Renal injury initiated by low to moderate doses of DCVC is repaired by timely and adequate stimulation of renal cell division, tubular repair, restoration of renal structure and function leading to survival of mice. Recent studies have established that mice primed with a low dose of DCVC (15 mg/kg ip) 72 h before administration of a normally lethal dose (75 mg/kg ip) are protected from ARF and death (nephro-autoprotection). We showed that renal cell division and tissue repair stimulated by the low dose are sustained even after the lethal dose administration resulting in survival from ARF and death. If renal cell division induced by the low dose is indeed the critical mechanism of this autoprotection, then its ablation by the antimitotic agent colchicine (1.5 mg CLC/kg ip) should abolish autoprotection. The present interventional experiments were designed to test the hypothesis that DCVC autoprotection is due to stimulated cell division and tissue repair by the priming low dose. CLC intervention at 42 and 66 h after the priming dose resulted in marked progressive elevation of plasma blood urea nitrogen and creatinine resulting in ARF and death of mice. Light microscopic examination of hematoxylin and eosin-stained kidney sections revealed progression of renal necrosis concordant with progressively failing renal function. With CLC intervention, S-phase stimulation (as assessed by BrdU pulse labeling), G1-to-S phase clearance, and cell division were diminished essentially abolishing the promitogenic effect of the priming low dose of DCVC. Phospho-retinoblastoma protein (P-pRB), a crucial protein for S-phase stimulation, and other cellular signaling mechanisms regulating P-pRB were investigated. We report that decreased P-pRB via activation of protein phosphatase-I by CLC is the critical mechanism of this inhibited S-phase stimulation and ablation of autoprotection with CLC intervention. These findings lend additional support to the notion that stimulated cell division and renal tissue repair by the priming dose of DCVC are the critical mechanisms that allow sustained compensatory tissue repair and survival of mice in nephro-autoprotection. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS -- Mechanical properties
KW - CELL proliferation
KW - CELL division (Biology)
KW - KIDNEY diseases
KW - URINALYSIS
KW - CELLULAR signal transduction
KW - COLCHICINE
KW - colchicine
KW - phospho-retinoblastoma
KW - tissue repair
N1 - Accession Number: 21731389; Korrapati, Midhun C. 1 Chilakapati, Jaya 1 Lock, Edward A. 2 Latendresse, John R. 3 Warbritton, Alan 3 Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliation: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana Monroe, Monroe, Louisiana 2: School of Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom 3: Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas; Source Info: Aug2006, Vol. 60 Issue 2, pF439; Subject Term: CELLS -- Mechanical properties; Subject Term: CELL proliferation; Subject Term: CELL division (Biology); Subject Term: KIDNEY diseases; Subject Term: URINALYSIS; Subject Term: CELLULAR signal transduction; Subject Term: COLCHICINE; Author-Supplied Keyword: colchicine; Author-Supplied Keyword: phospho-retinoblastoma; Author-Supplied Keyword: tissue repair; Number of Pages: 17p; Illustrations: 4 Color Photographs, 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1152/ajprenal.00384.2005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21731389&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Matthew M.
AU - Broder, Karen R.
AU - Cowan, Anne E.
AU - Mijalski, Christina
AU - Kretsinger, Katrina
AU - Stokley, Shannon
AU - Clark, Sarah J.
T1 - Physician Attitudes and Preferences About Combined Tdap Vaccines for Adolescents
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2006/08//
VL - 31
IS - 2
M3 - Article
SP - 176
EP - 180
SN - 07493797
AB - Background: Combined tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) boosters for adolescents are a new strategy to prevent pertussis. We examined the current practices of pediatricians and family physicians regarding adolescent tetanus and diphtheria toxoids (Td) vaccine immunizations and providers’ potential adherence to new Tdap recommendations for adolescents. Methods: Using a brief survey instrument sent to a random sample of pediatricians and family physicians in January 2005, we assessed providers’ patterns of administration of Td boosters, barriers to Td boosters, and agreement that pertussis vaccination of adolescents is warranted. Results of analyses in February 2005 were presented to the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention (CDC) to inform its deliberations regarding adolescent Tdap vaccination. Results: The overall response rate was 56% (57% pediatricians, 55% family physicians). Among 297 respondents (154 pediatricians, 143 family physicians) eligible for analysis because they provide care to adolescents, pediatricians (77%) were significantly more likely than family physicians (51%, p <0.0001) to report that they routinely administer Td at preventive care visits for adolescents aged 11 to 12 years, but otherwise the specialties were similar in their Td practices. Forty-four percent of respondents cited infrequency of adolescent visits as a barrier to Td immunization. Slightly more than half the sample (57%) agreed or strongly agreed that pertussis is serious enough to warrant replacing Td with Tdap for adolescents; pediatricians (70%) were significantly more likely than family physicians (42%, p <0.0001) to endorse this statement. Conclusions: This national survey indicates moderate willingness, stronger among pediatricians than among family physicians, to support recommendations for Tdap among adolescents. In February 2006, CDC released recommendations that adolescents aged 11 to 18 (preferred age 11 to 12) receive a single dose of Tdap in place of Td if they have not already received the latter. Near-term efforts regarding Tdap recommendations must address providers’ concerns about infrequent routine visits for adolescents and convince more physicians of the importance of pertussis booster immunization during adolescence. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS -- Health
KW - PHYSICIANS (General practice)
KW - IMMUNIZATION
KW - VACCINATION
N1 - Accession Number: 21589267; Davis, Matthew M. 1,2,3; Email Address: mattdav@med.umich.edu Broder, Karen R. 4,5 Cowan, Anne E. 1 Mijalski, Christina 4 Kretsinger, Katrina 4,5 Stokley, Shannon 4 Clark, Sarah J. 1; Affiliation: 1: Child Health Evaluation and Research Unit, Division of General Pediatrics, University of Michigan, Ann Arbor, Michigan, USA 2: Division of General Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA 3: Gerald R. Ford School of Public Policy, University of Michigan, Ann Arbor, Michigan, USA 4: National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 5: Commissioned Corps of the United States Public Health Service, Atlanta, Georgia, USA; Source Info: Aug2006, Vol. 31 Issue 2, p176; Subject Term: TEENAGERS -- Health; Subject Term: PHYSICIANS (General practice); Subject Term: IMMUNIZATION; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.amepre.2006.03.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Castor, Mei L.
AU - Smyser, Michael S.
AU - Taualii, Maile M.
AU - Park, Alice N.
AU - Lawson, Shelley A.
AU - Forquera, Ralph A.
T1 - A Nationwide Population-Based Study Identifying Health Disparities Between American Indians/Alaska Natives and the General Populations Living in Select Urban Counties.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/08//
VL - 96
IS - 8
M3 - Article
SP - 1478
EP - 1484
PB - American Public Health Association
SN - 00900036
AB - Objectives. Despite their increasing numbers, little is known about the health of American Indians/Alaska Natives living in urban areas. We examined the health status of American Indian/Alaska Native populations served by 34 federally funded urban Indian health organizations. Methods. We analyzed US census data and vital statistics data for the period 1990 to 2000. Results. Disparities were revealed in socioeconomic, maternal and child health, and mortality indicators between American Indians/Alaska Natives and the general populations in urban Indian health organization service areas and nationwide, American Indians/Alaska Natives were approximately twice as likely as these general populations to be poor, to be unemployed, and to not have a college degree. Similar differences were observed in births among mothers who received late or no prenatal care or consumed alcohol and in mortality attributed to sudden infant death syndrome, chronic liver disease, and alcohol consumption. Conclusions. We found health disparities between American Indians/Alaska Natives and the general populations living in selected urban areas and nationwide. Such disparities can be addressed through improvements in health care access, high-quality data collection, and policy initiatives designed to provide sufficient resources and a more unified vision of the health of urban American Indians/Alaska Natives. (Am J Public Health. 2006,96:1478-1484. doi:10.2105/AJPH.2004.053942) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH disparities
KW - SUDDEN infant death syndrome
KW - NATIVE Americans -- Health
KW - NATIVE Americans -- Medical care
KW - INFANTS -- Death
KW - LIVER diseases
KW - DRINKING of alcoholic beverages
KW - DRINKING behavior
KW - NATIVE Americans -- Education
KW - UNITED States
N1 - Accession Number: 21954742; Castor, Mei L. 1,2; Email Address: meic@uihi.org Smyser, Michael S. 3 Taualii, Maile M. 1 Park, Alice N. 1 Lawson, Shelley A. 3 Forquera, Ralph A. 1; Affiliation: 1: Urban Indian Health Institute, Seattle Indian Health Board, Seattle, Wash. 2: Indian Health Service, Albuquerque, NM. 3: Public Health — Seattle and King County, Seattle.; Source Info: Aug2006, Vol. 96 Issue 8, p1478; Subject Term: HEALTH disparities; Subject Term: SUDDEN infant death syndrome; Subject Term: NATIVE Americans -- Health; Subject Term: NATIVE Americans -- Medical care; Subject Term: INFANTS -- Death; Subject Term: LIVER diseases; Subject Term: DRINKING of alcoholic beverages; Subject Term: DRINKING behavior; Subject Term: NATIVE Americans -- Education; Subject Term: UNITED States; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 6353
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106340703
T1 - The impact of state laws limiting malpractice damage awards on health care expenditures.
AU - Hellinger FJ
AU - Encinosa WE
Y1 - 2006/08//
N1 - Accession Number: 106340703. Language: English. Entry Date: 20060929. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Damages, Legal -- Economics
KW - Government Regulations
KW - Health Care Costs
KW - Health Policy
KW - Malpractice
KW - Medical Care
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Geographic Factors
KW - Health Services Needs and Demand
KW - Income
KW - Jurisprudence
KW - Negligence
KW - Patient Safety
KW - Physician Attitudes
KW - Record Review
KW - Regression
KW - Resource Databases
KW - Time Series
KW - United States Centers for Medicare and Medicaid Services
KW - Human
SP - 1375
EP - 1381
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 96
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Twenty-eight states have laws that limit payments in malpractice cases, and several studies indicate that these laws reduce the frequency and severity of malpractice claims and lower premiums. Moreover, proponents believe that such laws reduce health care expenditures by reducing the practice of defensive medicine. However, there is a dearth of empirical evidence about the impact of these laws on the cost of health care. We used multivariate models and relatively recent data to estimate the impact of state tort reform laws that directly limit malpractice damage payments on health care expenditures. Estimates from these models suggest that laws limiting malpractice payments lower state health care expenditures by between 3% and 4%.
SN - 0090-0036
AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. fhelling@ahrq.gov
U2 - PMID: 16809580.
DO - 10.2105/AJPH.2005.077883
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106340964
T1 - Parental English proficiency and children's health services access.
AU - Yu SM
AU - Huang ZJ
AU - Schwalberg RH
AU - Nyman RM
Y1 - 2006/08//
N1 - Accession Number: 106340964. Language: English. Entry Date: 20060929. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Grant Information: Office of Data and Program Development, Maternal and Child Health Bureau. NLM UID: 1254074.
KW - Child Health -- California
KW - Communication Skills
KW - Health Resource Utilization -- California
KW - Health Services Accessibility -- In Infancy and Childhood -- California
KW - Medically Underserved -- California
KW - Parents -- Psychosocial Factors
KW - Adolescence
KW - Adult
KW - California
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Discrimination
KW - Emergency Service -- Utilization
KW - Health Status Indicators
KW - Infant
KW - Insurance, Health
KW - Interview Guides
KW - Language
KW - Logistic Regression
KW - Multi-Stage Cluster
KW - Odds Ratio
KW - P-Value
KW - Primary Health Care -- Utilization
KW - Random Sample
KW - Socioeconomic Factors
KW - Surveys
KW - Telephone
KW - Funding Source
KW - Human
SP - 1449
EP - 1455
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 96
IS - 8
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We examined the relation between parents' level of English proficiency and their children's access to health care. METHODS: Using the 2001 California Health Interview Survey, we conducted bivariate and multivariate analyses of several measures of children's access to health care (current health insurance status, usual source of care, emergency room visits, delayed or forgone care, traveling to another country for health care, and perceived discrimination in health care) and their association with parents' English proficiency. RESULTS: Compared with English-speaking households, children in non-English-speaking households were more likely to lack health insurance, to not have doctor contact, and to go to other countries for health care and were less likely to use emergency rooms. Their parents were less likely to report their children's experiencing delayed or forgone care or discrimination in health care. CONCLUSION: English proficiency is a strong predictor of access to health insurance for children, and children in non-English-speaking families are especially likely to rely on other countries for their health care. English proficiency may mitigate the effects of race/ethnicity commonly observed in health care access and utilization studies.
SN - 0090-0036
AD - Maternal and Child Health Bureau, Rockville, MD 20857, USA. syu@hrsa.gov
U2 - PMID: 16809589.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brazier, Jon S.
T1 - Human infections with Fusobacterium necrophorum
JO - Anaerobe
JF - Anaerobe
Y1 - 2006/08//
VL - 12
IS - 4
M3 - Article
SP - 165
EP - 172
SN - 10759964
AB - Abstract: Fusobacterium necrophorum is a Gram-negative anaerobic bacillus that can be a primary pathogen causing either localised abscesses and throat infections or systemic life-threatening disease. Systemic infections due to F. necrophorum are referred to as either Lemierre''s disease/syndrome, post-anginal sepsis or necrobacillosis, but in the context of this mini-review, all are included under the umbrella term of ‘invasive F. necrophorum disease’ (IFND). Although IFND has been well documented for over a century, it is quite a rare condition and modern-day clinicians of various medical disciplines are frequently unaware of this organism and the severity of symptoms that it can cause. IFND classically occurs in previously healthy young people although the factors that trigger the invasive process are not fully understood. There are countless descriptive case histories and small series of cases of IFND disease in the literature and although commonly referred to as a ‘forgotten’ disease, in truth, it is probably best described as a repeatedly ‘discovered’ disease, as it may not always be included in medical curricula, and neither is it mentioned in some major medical textbooks. There is some evidence that IFND may be on the increase, particularly in the UK. The potential reasons for this are considered in this review along with an historical overview, and updates on disease incidence, patient demography, pathogenesis and laboratory diagnosis. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFECTION
KW - SEPTICEMIA
KW - MEDICAL personnel
KW - SOCIAL status
N1 - Accession Number: 22283013; Brazier, Jon S. 1; Email Address: Brazier@cardiff.ac.uk; Affiliation: 1: Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK; Source Info: Aug2006, Vol. 12 Issue 4, p165; Subject Term: INFECTION; Subject Term: SEPTICEMIA; Subject Term: MEDICAL personnel; Subject Term: SOCIAL status; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.anaerobe.2005.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22283013&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volokhov, Dmitriy V.
AU - George, Joseph
AU - Liu, Sue X.
AU - Ikonomi, Pranvera
AU - Anderson, Christine
AU - Chizhikov, Vladimir
T1 - Sequencing of the intergenic 16S-23S rRNA spacer (ITS) region of Mollicutes species and their identification using microarray-based assay and DNA sequencing.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2006/08//
VL - 71
IS - 5
M3 - Article
SP - 680
EP - 698
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - We have completed sequencing the 16S-23S rRNA intergenic transcribed spacer (ITS) region of most known Mycoplasma , Acholeplasma , Ureaplasma , Mesoplasma , and Spiroplasma species. Analysis of the sequence data revealed a significant interspecies variability and low intraspecies polymorphism of the ITS region among Mollicutes . This finding enabled the application of a combined polymerase chain reaction–microarray technology for identifying Mollicutes species. The microarray included individual species-specific oligonucleotide probes for characterizing human Mollicutes species and other species known to be common cell line contaminants. Evaluation of the microarray was conducted using multiple, previously characterized, Mollicutes species. The microarray analysis of the samples used demonstrated a highly specific assay, which is capable of rapid and accurate discrimination among Mollicutes species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Mycoplasma
KW - Species
KW - Polymerase chain reaction
KW - Oligonucleotides
KW - Cell lines
N1 - Accession Number: 21638697; Volokhov, Dmitriy V. 1; Email Address: volokhov@cber.fda.gov; George, Joseph 1; Liu, Sue X. 1; Ikonomi, Pranvera 2; Anderson, Christine 1; Chizhikov, Vladimir 1; Affiliations: 1: Center of Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Viral Products, Laboratory of Methods Development, US Food and Drug Administration, HFM-470, 1401 Rockville Pike, Rockville, MD 20852, USA; 2: American Type Culture Collection (ATCC), 10801 University Boulevard, Manassas, VA 20108, USA; Issue Info: Aug2006, Vol. 71 Issue 5, p680; Thesaurus Term: RNA; Thesaurus Term: Mycoplasma; Thesaurus Term: Species; Subject Term: Polymerase chain reaction; Subject Term: Oligonucleotides; Subject Term: Cell lines; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 19p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00253-005-0280-7
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hurley, James H.
T1 - Membrane binding domains
JO - BBA - Molecular & Cell Biology of Lipids
JF - BBA - Molecular & Cell Biology of Lipids
Y1 - 2006/08//
VL - 1761
IS - 8
M3 - Article
SP - 805
EP - 811
SN - 13881981
AB - Abstract: Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes. [Copyright &y& Elsevier]
AB - Copyright of BBA - Molecular & Cell Biology of Lipids is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIAL genetics
KW - HYDROGEN-ion concentration
KW - PROTEIN kinases
KW - CELL membranes
KW - Diacylglycerol
KW - Membrane trafficking
KW - Phosphoinositide
KW - Protein kinase C
KW - Signal transduction
N1 - Accession Number: 22281960; Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Aug2006, Vol. 1761 Issue 8, p805; Subject Term: MICROBIAL genetics; Subject Term: HYDROGEN-ion concentration; Subject Term: PROTEIN kinases; Subject Term: CELL membranes; Author-Supplied Keyword: Diacylglycerol; Author-Supplied Keyword: Membrane trafficking; Author-Supplied Keyword: Phosphoinositide; Author-Supplied Keyword: Protein kinase C; Author-Supplied Keyword: Signal transduction; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbalip.2006.02.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22281960&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106110154
T1 - Upper body musculoskeletal disorders among Australian occupational therapy students.
AU - Smith DR
AU - Leggat PA
AU - Clark M
Y1 - 2006/08//8/1/2006
N1 - Accession Number: 106110154. Language: English. Entry Date: 20070629. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Instrumentation: Standardised Nordic Questionnaire for the Analysis of Musculoskeletal Symptoms (Kuorinka et al). NLM UID: 7708186.
KW - Musculoskeletal Diseases -- Epidemiology -- Queensland
KW - Occupational Diseases -- Epidemiology -- Queensland
KW - Students, Occupational Therapy
KW - Adult
KW - Back
KW - Chi Square Test
KW - Clinical Assessment Tools
KW - Confidence Intervals
KW - Data Analysis Software
KW - Female
KW - Fisher's Exact Test
KW - Musculoskeletal Diseases -- Risk Factors
KW - Neck
KW - Occupational Diseases -- Risk Factors
KW - Odds Ratio
KW - One-Way Analysis of Variance
KW - Prevalence
KW - Queensland
KW - Questionnaires
KW - Scales
KW - Shoulder
KW - Surveys
KW - Human
SP - 365
EP - 372
JO - British Journal of Occupational Therapy
JF - British Journal of Occupational Therapy
JA - BR J OCCUP THER
VL - 69
IS - 8
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Although upper body musculoskeletal disorders (MSDs) represent an increasingly important issue for university students, few if any studies have targeted the occupational therapy faculty. Given this dearth of information, it was considered necessary to investigate a cross-section of Australian occupational therapy students by means of an established questionnaire survey. Completed replies were obtained from 95.7%, 100% and 97.7% (n = 44, 55 and 48) of students in the first, second and fourth years of a large occupational therapy school in northern Queensland, Australia.The 12-month period prevalence of MSDs was as follows: neck (6744%x, shoulder (46.3%) and upper back (39.5%). Three-quarters of all students (75.5%) reported an MSD occurring in at least one of these body regions. Over half (56.5%) reported an MSD over 2 days' duration in the past year. Almost 40% (39.5%) reported an MSD that had affected their daily life, while one-quarter (25.2%) needed some type of treatment.Logistic regression indicated that students aged over 21 years were almost four times more likely to report shoulder-related MSD (OR 3.7, 95%CI: 1.4-10.2). Year of study in the occupational therapy course was another important MSD correlate, with adjusted odds ratios ranging from 3.3 at the upper back (OR 3.3, 95%CI: 1.2-9.6) to 10.9 at the neck (OR 10.9, 95%CI: 3.2-43.8). Computer usage also incurred a certain degree of risk, with students who spent over 5 hours per week on the computer having an increased risk of MSD at the neck (OR 5.0, 95%CI: 1.3-21.5) and shoulder (OR 4.7, 95%CI: 1.4-18.3).Overall, this study suggests that Australian occupational therapy students have a large burden from MSDs in the upper body region, even more so than other student groups and some working populations. Since the distribution of MSD risk is not uniform among them, interventions to help reduce these conditions need to be carefully targeted. Further longitudinal investigations would also be useful in determining the mechanisms and contributory factors for MSDs among this unique student population.
SN - 0308-0226
AD - Research Scientist, International Centre for Research Promotion and Informatics, Japan National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585 Japan; smith@nih.go.jp
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Budhu, Anuradha
AU - Forgues, Marshonna
AU - Ye, Qing-Hai
AU - Jia, Hu-Liang
AU - He, Ping
AU - Zanetti, Krista A.
AU - Kammula, Udai S.
AU - Chen, Yidong
AU - Qin, Lun-Xiu
AU - Tang, Zhao-You
AU - Wang, Xin Wei
T1 - Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
JO - Cancer Cell
JF - Cancer Cell
Y1 - 2006/08//
VL - 10
IS - 2
M3 - Article
SP - 99
EP - 111
SN - 15356108
AB - Summary: Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or postsurgical recurrence. We postulate that metastases are influenced by the liver microenvironment. Here, we show that a unique inflammation/immune response-related signature is associated with noncancerous hepatic tissues from metastatic HCC patients. This signature is principally different from that of the tumor. A global Th1/Th2-like cytokine shift in the venous metastasis-associated liver microenvironment coincides with elevated expression of macrophage colony-stimulating factor (CSF1). Moreover, a refined 17 gene signature was validated as a superior predictor of HCC venous metastases in an independent cohort, when compared to other clinical prognostic parameters. We suggest that a predominant humoral cytokine profile occurs in the metastatic liver milieu and that a shift toward anti-inflammatory/immune-suppressive responses may promote HCC metastases. [Copyright &y& Elsevier]
AB - Copyright of Cancer Cell is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Cancer
KW - METASTASIS
KW - INFLAMMATION
KW - MACROPHAGES
KW - PATHOLOGY
N1 - Accession Number: 21920526; Budhu, Anuradha 1 Forgues, Marshonna 1 Ye, Qing-Hai 2 Jia, Hu-Liang 1,2 He, Ping 3 Zanetti, Krista A. 4 Kammula, Udai S. 5 Chen, Yidong 6 Qin, Lun-Xiu 2 Tang, Zhao-You 2; Email Address: zytang8@yahoo.com.cn Wang, Xin Wei 1; Email Address: xw3u@nih.gov; Affiliation: 1: Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 2: Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China 3: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 4: Molecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis and Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892 5: Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892 6: Laboratory of Cancer Genetics, National Human Genome Research Institute, Bethesda, Maryland 20892; Source Info: Aug2006, Vol. 10 Issue 2, p99; Subject Term: LIVER -- Cancer; Subject Term: METASTASIS; Subject Term: INFLAMMATION; Subject Term: MACROPHAGES; Subject Term: PATHOLOGY; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.ccr.2006.06.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei Lin Wang
AU - Avashia, Bipin H.
AU - Petsonk, Edward L.
T1 - Interpreting Periodic Lung Function Tests in Individuals.
JO - CHEST
JF - CHEST
Y1 - 2006/08//
VL - 130
IS - 2
M3 - Article
SP - 493
EP - 499
SN - 00123692
AB - The article presents a study which describes the relationship between the changes in the peak forced expiratory volume (FEV1over to five years and FEV1 declines on longer periods, through spirometry. Findings indicated that individuals with abnormal short-term declines were three to eighteen times more likely to ultimately show excessive long term declines; having the strength of the association increasing the length of the short term testing interval.
KW - FUNCTION tests (Medicine)
KW - SPIROMETRY
KW - RESPIRATORY measurements
KW - VENTILATION-perfusion ratio
KW - EMPLOYEES
KW - diagnostic tests
KW - routine spirometly
KW - sensitivity
KW - specificity
N1 - Accession Number: 22157725; Mei Lin Wang 1 Avashia, Bipin H. 2 Petsonk, Edward L. 1; Email Address: elp2@cdc.gov; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety an Health, Centers for Disease Control and Prevention, Morgantown, WV 2: Medical Department, Bayer Crop-Science, Charleston, WV; Source Info: Aug2006, Vol. 130 Issue 2, p493; Subject Term: FUNCTION tests (Medicine); Subject Term: SPIROMETRY; Subject Term: RESPIRATORY measurements; Subject Term: VENTILATION-perfusion ratio; Subject Term: EMPLOYEES; Author-Supplied Keyword: diagnostic tests; Author-Supplied Keyword: routine spirometly; Author-Supplied Keyword: sensitivity; Author-Supplied Keyword: specificity; Number of Pages: 7p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1378/chest.130.2.493
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yeang, H.-Y.
AU - Hamilton, R. G.
AU - Bernstein, D. I.
AU - Arif, S. A. M.
AU - Chow, K. -S.
AU - Loke, Y. -H.
AU - Raulf-Heimsoth, M.
AU - Wagner, S.
AU - Breiteneder, H.
AU - Biagini, R. E.
T1 - Allergen concentration in natural rubber latex.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2006/08//
VL - 36
IS - 8
M3 - Article
SP - 1078
EP - 1086
PB - Wiley-Blackwell
SN - 09547894
AB - Background Hevea brasiliensis latex serum is commonly used as the in vivo and in vitro reference antigen for latex allergy diagnosis as it contains the full complement of latex allergens. Objective This study quantifies the concentrations of the significant allergens in latex serum and examines its suitability as an antigen source in latex allergy diagnosis and immunotherapy. Methods The serum phase was extracted from centrifuged latex that was repeatedly freeze-thawed or glycerinated. Quantitation of latex allergens was performed by two-site immunoenzymetric assays. The abundance of RNA transcripts of the latex allergens was estimated from the number of their clones in an Expressed Sequence Tags library. Results The latex allergens, Hev b 1, 2, 3, 4, 5, 6, 7 and 13, were detected in freeze-thawed and glycerinated latex serum at levels ranging from 75 (Hev b 6) to 0.06 nmol/mg total proteins (Hev b 4). Hev b 6 content in the latex was up to a thousand times higher than the other seven latex allergens, depending on source and/or preparation procedure. Allergen concentration was reflected in the abundance of mRNA transcripts. When used as the antigen, latex serum may bias the outcome of latex allergy diagnostic tests towards sensitization to Hev b 6. Tests that make use of latex serum may fail to detect latex-specific IgE reactivity in subjects who are sensitized only to allergens that are present at low concentrations. Conclusion Latex allergy diagnostics and immunotherapy that use whole latex serum as the antigen source may not be optimal because of the marked imbalance of its constituent allergens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Antigens
KW - Allergy
KW - Latex allergy
KW - Rubber
KW - Immunotherapy
KW - diagnostic
KW - EST
KW - Hevea brasiliensis
KW - IEMA
KW - immunoassay
KW - immunotherapy
KW - latex
KW - latex allergy
KW - natural rubber serology
KW - skin prick test
N1 - Accession Number: 21784926; Yeang, H.-Y. 1; Hamilton, R. G. 2; Bernstein, D. I. 3; Arif, S. A. M. 1; Email Address: sitiarija@lgm.gov.my; Chow, K. -S. 1; Loke, Y. -H. 1; Raulf-Heimsoth, M. 4; Wagner, S. 5; Breiteneder, H. 5; Biagini, R. E. 6; Affiliations: 1: Biotechnology and Strategic Research Unit, Rubber Research Institute of Malaysia, Malaysian Rubber Board, Malaysia,; 2: Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA,; 3: Division of Allergy/Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA,; 4: Allergy/Immunology Division, Institute of Occupational Medicine, Bochum, Germany,; 5: Department of Pathophysiology, Medical University of Vienna, Austria and; 6: Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, OH, USA; Issue Info: Aug2006, Vol. 36 Issue 8, p1078; Thesaurus Term: Allergens; Thesaurus Term: Antigens; Thesaurus Term: Allergy; Subject Term: Latex allergy; Subject Term: Rubber; Subject Term: Immunotherapy; Author-Supplied Keyword: diagnostic; Author-Supplied Keyword: EST; Author-Supplied Keyword: Hevea brasiliensis; Author-Supplied Keyword: IEMA; Author-Supplied Keyword: immunoassay; Author-Supplied Keyword: immunotherapy; Author-Supplied Keyword: latex; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: natural rubber serology; Author-Supplied Keyword: skin prick test; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; Number of Pages: 9p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2222.2006.02531.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Case, H. Samuel
AU - Reed, H. Lester
AU - Palinkas, Lawrence A.
AU - Reedy, Kathleen R.
AU - Van Do, Nhan
AU - Finney, Nancy S.
AU - Seip, Richard
T1 - Resting and exercise energy use in Antarctica: effect of 50% restriction in temperate climate energy requirements.
JO - Clinical Endocrinology
JF - Clinical Endocrinology
Y1 - 2006/08//
VL - 65
IS - 2
M3 - Article
SP - 257
EP - 264
PB - Wiley-Blackwell
SN - 03000664
AB - Objective To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). Design Prospective, intervention with both paired controls and a similar reference control group (RG). Patients and measurements Seven subjects were assessed before and after a 50% ER period of 60 h. This ER was carried out within 30 days of arriving in Antarctica in October (OCT) and again after 10 months AR in August (AUG). During the periods of ER, mean energy consumption was 5662 ± 1344 kJ/day in OCT and 5529 ± 967 kJ/day in AUG. Resting metabolic rate (RMR), a calculated resting metabolic rate (RMRreg) using a submaximal work regression, serum TSH, FT3 and tympanic temperature (Tty) were measured. These values were compared with a similar RG of 12 subjects reported previously who were studied in California, USA before and then again during AR. Results Weight declined by 1·1 ± 0·1 kg/day (OCT) and 0·92 ± 0·2 kg/day (AUG) with ER, resulting in a reduction of body weight by 3·1 ± 0·4% in OCT ( P = 0·0001) and 2·5 ± 0·4% in AUG ( P = 0·0015) during AR. The RMR before ER did not change with AR and it was not significantly different from the RG studied in California. With ER the RMR tended to decline in both OCT (132 ± 5 to 122 ± 4 mlO2/min/m2) and AUG (134 ± 5 to 126 ± 5 mlO2/min/m2), but these were not significant. By contrast, RMRreg obtained before ER was increased with AR by 22·5 ± 7·8% ( P = 0·01) in OCT and by 28·1 ± 7·0% ( P = 0·0008) in AUG over the RG values obtained in California. RMRreg did not decrease with ER in either OCT or AUG. The total energy expenditure derived from these measures of weight loss suggests that 24-h energy requirements are 74·4%[95% confidence interval (CI) 2·6–146·3; P<0·05] more than those expected in temperate climates. Tty declined by 0·6 ± 0·2 °C ( P<0·01) with AR compared with the RG measured in California, but was not affected by either period of ER. ER had no effect on FT3 but tended to decrease serum TSH in AUG ( P = 0·06). Conclusions Exercise-related energy requirements are increased with AR. Moderate ER may reduce resting but not exercise-related energy expenditure and it is associated with a weight loss exceeding expectations for 50% restriction of temperate climate energy predictions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Endocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FORCE & energy
KW - TEMPERATE climate
KW - CLIMATOLOGY
KW - ENDOCRINOLOGY
KW - INTERNAL medicine
KW - ANTARCTICA
N1 - Accession Number: 21588454; Case, H. Samuel 1; Email Address: scase@mcdaniel.edu Reed, H. Lester 2 Palinkas, Lawrence A. 3 Reedy, Kathleen R. 4 Van Do, Nhan 5 Finney, Nancy S. 5 Seip, Richard 6; Affiliation: 1: Department of Exercise Science and Physical Education, McDaniel College, Westminster, MD 2: MultiCare Health System, Tacoma, WA 3: School of Social Work, University of Southern California, Los Angeles, CA 4: US Food and Drug Administration, Rockville, MD 5: Department of Medicine and Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA 6: Hartford Hospital, Hartford, CT, USA; Source Info: Aug2006, Vol. 65 Issue 2, p257; Subject Term: FORCE & energy; Subject Term: TEMPERATE climate; Subject Term: CLIMATOLOGY; Subject Term: ENDOCRINOLOGY; Subject Term: INTERNAL medicine; Subject Term: ANTARCTICA; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2265.2006.02588.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fox, R.
AU - Nix, A. B. J.
AU - Fielder, H.
T1 - A comparison of variability in Papanicolaou and liquid-based cytology inadequacy rates using Shewhart control charts.
JO - Cytopathology
JF - Cytopathology
Y1 - 2006/08//
VL - 17
IS - 4
M3 - Article
SP - 175
EP - 181
PB - Wiley-Blackwell
SN - 09565507
AB - Objective: To use Shewhart control charts to compare variability in inadequacy rates from Papanicolaou (Pap) and liquid-based cytology (LBC). Design: Retrospective analysis of quality assurance data. Setting: Eleven Welsh cytology laboratories. Methods: Shewhart ‘p’ charts were plotted for proportions of slides reported as inadequate. Charts were compared for statistical control. Main outcome measures: Evidence of statistical control in the processes. Results: Control charts allowed easy interpretation of patterns in the data. Variability in inadequacy rates was much lower for LBC than for Pap cytology. Conclusion: Monitoring inadequate rates with Shewhart charts provides more information than tabular monitoring reports, assisting in quality improvement. With respect to inadequacy rates, LBC is less variable than Pap cytology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cytopathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAP test
KW - CYTOLOGY
KW - QUALITY control -- Charts, diagrams, etc.
KW - LABORATORIES
KW - QUALITY assurance
KW - WALES
KW - cervical cytology
KW - control chart
KW - inadequacy rates
KW - liquid-based cytology
KW - performance improvement
KW - quality assurance
KW - statistical process control
N1 - Accession Number: 21603853; Fox, R. 1; Email Address: rosemary.fox@nphs.wales.nhs.uk Nix, A. B. J. 2 Fielder, H. 3; Affiliation: 1: National Public Health Service for Wales, Temple of Peace and Health, Cardiff, UK 2: Department of Epidemiology, Statistics and Public Health, University of Wales College of Medicine, Cardiff, UK 3: Cervical Screening Wales, Cardiff, UK; Source Info: Aug2006, Vol. 17 Issue 4, p175; Subject Term: PAP test; Subject Term: CYTOLOGY; Subject Term: QUALITY control -- Charts, diagrams, etc.; Subject Term: LABORATORIES; Subject Term: QUALITY assurance; Subject Term: WALES; Author-Supplied Keyword: cervical cytology; Author-Supplied Keyword: control chart; Author-Supplied Keyword: inadequacy rates; Author-Supplied Keyword: liquid-based cytology; Author-Supplied Keyword: performance improvement; Author-Supplied Keyword: quality assurance; Author-Supplied Keyword: statistical process control; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; Number of Pages: 7p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2303.2006.00302.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongwen Zhao
AU - Barger, Mark W.
AU - Ma, Joseph K. H.
AU - Castranova, Vincent
AU - Ma, Jane Y. C.
T1 - Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/08//
VL - 114
IS - 8
M3 - Article
SP - 1253
EP - 1258
PB - Superintendent of Documents
SN - 00916765
AB - Diesel exhaust particles (DEPs) have been shown to activate oxidant generation by alveolar macrophages (AMs), alter xenobiotic metabolic pathways, and modify the balance of pro-antiinflammatory cytokines. In this study we investigated the role of nitric oxide (NO) in DEP-mediated and DEP organic extract (DEPE)-mediated inflammatory responses and evaluated the interaction of inducible NO synthase (iNOS) and cytochrome P450 1A1 (CYP1A1). Male Sprague-Dawley rats were intratracheally (IT) instilled with saline, DEPs (35 mg/kg), or DEPEs (equivalent to 35 mg DEP/kg), with or without further treatment with an iNOS inhibitor, aminoguanidine (AG; 100 mg/kg), by intraperitoneal injection 30 min before and 3, 6, and 9 hr after IT exposure. At 1 day postexposure, both DEPs and DEPEs induced iNOS expression and NO production by AMs. AG significantly lowered DEP- and DEPE-induced iNOS activity but not the protein level while attenuating DEPE- but not DEP-mediated pulmonary inflammation, airway damage, and oxidant generation by AMs. DEP or DEPE exposure resulted in elevated secretion of both interleukin (IL)-12 and IL-10 by AMs. AG significantly reduced DEP- and DEPE-activated AMs in IL-12 production. In comparison, AG inhibited IL-10 production by DEPE-exposed AMs but markedly increased its production by DEP-exposed AMs, suggesting that NO differentially regulates the pro- and antiinflammatory cytokine balance in the lung. Both DEPs and DEPEs induced CYP1A1 expression. AG strongly inhibited CYP1A1 activity and lung S9 activity-dependent 2-aminoanthracene mutagenicity. These studies show that NO plays a major role in DEPE-induced lung inflammation and CYP-dependent mutagen activation but a lesser role in particulate-induced inflammatory damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytochrome P-450
KW - Nitric oxide
KW - Pneumonia
KW - Lungs
KW - Macrophages
KW - Anti-inflammatory agents
KW - Intraperitoneal injections
KW - Intratracheal anesthesia
KW - Interleukin-12
KW - Cytokines
KW - cytochrome P450 1A1
KW - cytokine production
KW - diesel exhaust particles
KW - inflammation
KW - mutagenicity
KW - nitric oxide
N1 - Accession Number: 21992825; Hongwen Zhao 1; Barger, Mark W. 2; Ma, Joseph K. H. 3; Castranova, Vincent 2; Ma, Jane Y. C. 2; Email Address: jym1@cdc.gov; Affiliations: 1: Institute of Respiratory Diseases, First Affiliated Hospital, China Medical University, Shenyang, People’s Republic of China; 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 3: School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA; Issue Info: Aug2006, Vol. 114 Issue 8, p1253; Thesaurus Term: Cytochrome P-450; Thesaurus Term: Nitric oxide; Subject Term: Pneumonia; Subject Term: Lungs; Subject Term: Macrophages; Subject Term: Anti-inflammatory agents; Subject Term: Intraperitoneal injections; Subject Term: Intratracheal anesthesia; Subject Term: Interleukin-12; Subject Term: Cytokines; Author-Supplied Keyword: cytochrome P450 1A1; Author-Supplied Keyword: cytokine production; Author-Supplied Keyword: diesel exhaust particles; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: mutagenicity; Author-Supplied Keyword: nitric oxide; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.9063
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106372002
T1 - Exposure to school children as a risk factor in a community outbreak of hepatitis A in young adults: a case control study.
AU - Roberts RJ
AU - Palmer SR
Y1 - 2006/08//
N1 - Accession Number: 106372002. Language: English. Entry Date: 20061208. Revision Date: 20150711. Publication Type: Journal Article; case study; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Disease Outbreaks
KW - Hepatitis A -- Epidemiology -- Wales
KW - Hepatitis A -- Transmission
KW - Adolescence
KW - Adult
KW - Case Control Studies
KW - Chi Square Test
KW - Child
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Fisher's Exact Test
KW - Hepatitis A -- Risk Factors
KW - Male
KW - Mantel-Haenszel Test
KW - Questionnaires
KW - Risk Factors
KW - Wales
KW - Human
SP - 803
EP - 807
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 134
IS - 4
PB - Cambridge University Press
AB - To investigate risk factors during a community outbreak of hepatitis A we carried out a case- control study of 35 cases and 49 matched controls using an interviewer-administered questionnaire on clinical history, travel, household details including domestic toilet facilities, infectious contacts, and food history. Of 99 cases notified in the city during the outbreak year, 50 (51%) were young adults age 15-34 years. Hepatitis A infection was independently associated with household contact with a case (P=0.0005), and sharing a household with children in primary school (OR 3.4, 95% CI 1.2-9.5, P=0.008) with risk increasing with number of primary-school pupils in the household (chi2 for linear trend 6.47, P=0.01). We concluded that in a population with a low prevalence of hepatitis A, adults who live in the same household as primary-school-age children are at increased risk of acquiring the infection during community outbreaks.
SN - 0950-2688
AD - National Public Health Service, Preswylfa, Mold, Flintshire, UK.
U2 - PMID: 16316491.
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DB - rzh
ER -
TY - JOUR
AU - Rasanathan, Kumanan
AU - Craig, David
AU - Perkins, Rod
T1 - The Novel Use of ‘Asian’ as an Ethnic Category in the New Zealand Health Sector.
JO - Ethnicity & Health
JF - Ethnicity & Health
Y1 - 2006/08//
VL - 11
IS - 3
M3 - Article
SP - 211
EP - 227
PB - Routledge
SN - 13557858
AB - ‘Asian’ is increasingly used as an ethnic category in the health sector in New Zealand but does not have a ‘natural’, fixed, uncontested meaning. Two differing constructions of ‘Asian’ are commonly used in New Zealand. One is racially based and includes only East and Southeast Asian peoples. It is commonly employed in popular discourse and by the media. The other construction includes peoples from East, South and Southeast Asia, but excludes peoples from the Middle East and Central Asia. This construction is recent and unique to New Zealand and is being increasingly operationalised in the health sector. This use for planning and research is problematic. For the health sector, ‘Asian’ does not differentiate a group of people with shared characteristics in terms of health status or needs. The diversity of the ‘Asian’ category, with several axes of difference, will result in an averaging of health indicators. This may result in the high health needs of groups within this category being masked or the inappropriate targeting of services. Another major concern is the general lack of acknowledgement of the contestable nature of the ‘Asian’ category or justification for its use. However, the ‘Asian’ category provides a political platform to advocate for resources and enable research into the previously ignored health status of the diverse ‘Asian’ population. Despite its shortcomings, usage of the category is likely to continue in the New Zealand health sector. As such, the sector needs to be aware of the limitations of the category and show greater precision in its use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Ethnicity & Health is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHNICITY
KW - HEALTH status indicators
KW - ASIANS
KW - INDIGENOUS peoples of the Americas
KW - CHINESE
KW - NEW Zealand
KW - Asian
KW - Chinese
KW - Ethnicity
KW - Indian
KW - New Zealand
N1 - Accession Number: 21194171; Rasanathan, Kumanan 1; Email Address: kumananr@yahoo.com Craig, David Perkins, Rod; Affiliation: 1: Auckland Regional Public Health Service, Private Bag 92 605, Symonds Street, Auckland, New Zealand; Source Info: Aug2006, Vol. 11 Issue 3, p211; Subject Term: ETHNICITY; Subject Term: HEALTH status indicators; Subject Term: ASIANS; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: CHINESE; Subject Term: NEW Zealand; Author-Supplied Keyword: Asian; Author-Supplied Keyword: Chinese; Author-Supplied Keyword: Ethnicity; Author-Supplied Keyword: Indian; Author-Supplied Keyword: New Zealand; Number of Pages: 17p; Illustrations: 1 Black and White Photograph, 1 Chart, 1 Map; Document Type: Article
L3 - 10.1080/13557850600565525
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mills, G. D.
AU - Lala, H. M.
AU - Oehley, M. R.
AU - Craig, A. B.
AU - Barratt, K.
AU - Hood, D.
AU - Thornley, C. N.
AU - Nesdale, A.
AU - Manikkam, N. E.
AU - Reeve, P.
T1 - Elevated procalcitonin as a diagnostic marker in meningococcal disease.
JO - European Journal of Clinical Microbiology & Infectious Diseases
JF - European Journal of Clinical Microbiology & Infectious Diseases
Y1 - 2006/08//
VL - 25
IS - 8
M3 - Article
SP - 501
EP - 509
SN - 09349723
AB - Patients with meningococcal disease who seek medical attention can create a diagnostic dilemma for clinicians due to the nonspecific nature of the disease’s presentation. This study assesses the diagnostic accuracy of procalcitonin levels in the setting of meningococcal disease. Two emergency department cohorts (A and B) were studied between 2002 and 2005, during the current epidemic of serogroup B meningococcal disease in New Zealand. Cohort A consisted of 171 patients, all with confirmed meningococcal disease (84 children, 87 adults). Cohort B consisted of a large ( n=1,524) consecutively recruited population of febrile patients who presented to the emergency department, 28 of whom had confirmed meningococcal disease. Within the meningococcal disease cohort (cohort A), the geometric mean procalcitonin level was 9.9 ng/ml, with levels being higher in children than in adults (21.6 vs. 4.6 ng/ml, p=0.01). The overall sensitivity of elevated procalcitonin, using a cutoff of 2.0 ng/ml in children and 0.5 ng/ml in adults, was 0.93 (95%CI: 0.88–0.96). Despite the higher cutoff level for paediatric patients, a trend towards greater sensitivity existed in children (0.96 vs. 0.90; p=0.08). Elevated procalcitonin was correlated with whole blood meningococcal load ( r=0.50) and Glasgow Meningococcal Sepsis Prognostic Score ( r=0.40). Within the cohort of patients who were febrile on presentation (cohort B), the specificity of elevated procalcitonin in meningococcal disease was 0.85 (95% CI: 0.83–0.87), the positive and negative likelihood ratios were 6.1 and 0.08, respectively, and the sensitivity of elevated procalcitonin (0.93; 95% CI: 0.76–0.99) was corroborated. Measurement of procalcitonin is a useful tool in patients with nonspecific febrile illnesses when the possibility of meningococcal disease is present. The diagnostic accuracy surpasses that of current early laboratory markers, allowing results to be used to guide decisions about patient management. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Clinical Microbiology & Infectious Diseases is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - CALCITONIN
KW - THERAPEUTICS
KW - JUVENILE diseases
KW - MENINGITIS
KW - NEW Zealand
N1 - Accession Number: 21950767; Mills, G. D. 1; Email Address: millsg@waikatodhb.govt.nz Lala, H. M. 1 Oehley, M. R. 1 Craig, A. B. 2 Barratt, K. 3 Hood, D. 4 Thornley, C. N. 5 Nesdale, A. 6 Manikkam, N. E. 2 Reeve, P. 7; Affiliation: 1: Infectious Diseases Department, Waikato Hospital, Private Bag 3200, Hamilton, New Zealand 2: Paediatric Department, Waikato District Health Board, Private Bag 3200, Hamilton, New Zealand 3: Molecular Biology Department, Waikato District Health Board, Private Bag 3200, Hamilton, New Zealand 4: Waikato Public Health Service, Waikato District Health Board, Private Bag 3200, Hamilton, New Zealand 5: Auckland Regional Public Health Service, Auckland District Health Board, Private Bag 92605, Symonds Street, Auckland, New Zealand 6: Wellington Regional Public Health, Hutt Valley District Health Board, Private Bag 31907, Lower Hutt, New Zealand 7: General Medicine, Waikato District Health Board, Private Bag 3200, Hamilton, New Zealand; Source Info: Aug2006, Vol. 25 Issue 8, p501; Subject Term: NEISSERIA meningitidis; Subject Term: CALCITONIN; Subject Term: THERAPEUTICS; Subject Term: JUVENILE diseases; Subject Term: MENINGITIS; Subject Term: NEW Zealand; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1007/s10096-006-0179-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21950767&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wokovich, Anna M.
AU - Prodduturi, Suneela
AU - Doub, William H.
AU - Hussain, Ajaz S.
AU - Buhse, Lucinda F.
T1 - Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute
JO - European Journal of Pharmaceutics & Biopharmaceutics
JF - European Journal of Pharmaceutics & Biopharmaceutics
Y1 - 2006/08//
VL - 64
IS - 1
M3 - Article
SP - 1
EP - 8
SN - 09396411
AB - Abstract: Transdermal drug delivery systems (TDDS), also known as “patches,” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. In the Drug Quality Reporting System (DQRS), the United States Food and Drug Administration (FDA) has received numerous reports of “adhesion lacking” for transdermal drug delivery systems. This article provides an overview of types of transdermals, their anatomy, the role of adhesion, the possible adhesion failure modes and how adhesion can be measured. Excerpts from FDA reports on the lack of adhesion of transdermal system products are presented. Pros and cons of in vitro techniques, such as peel adhesion, tack and shear strength, in vivo techniques used to evaluate adhesive properties are discussed. To see a decrease in “adhesion lacking” reports, adhesion needs to become an important design parameter and suitable methods need to be available to assess quality and in vivo performance. This article provides a framework for further discussion and scientific work to improve transdermal adhesive performance. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutics & Biopharmaceutics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSDERMAL medication
KW - BIOADHESIVE drug delivery systems
KW - SAFETY
KW - PHARMACEUTICAL technology
KW - Adhesion
KW - Drug delivery
KW - Patch
KW - Peel
KW - Shear
KW - Tack
KW - Transdermal drug delivery system
KW - Transdermal system
N1 - Accession Number: 21827950; Wokovich, Anna M. 1; Email Address: anna.wokovich@fda.hhs.gov Prodduturi, Suneela 1 Doub, William H. 1 Hussain, Ajaz S. 2 Buhse, Lucinda F. 1; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO, USA 2: Food and Drug Administration, Office of Pharmaceutical Science, Silver Spring, MD, USA; Source Info: Aug2006, Vol. 64 Issue 1, p1; Subject Term: TRANSDERMAL medication; Subject Term: BIOADHESIVE drug delivery systems; Subject Term: SAFETY; Subject Term: PHARMACEUTICAL technology; Author-Supplied Keyword: Adhesion; Author-Supplied Keyword: Drug delivery; Author-Supplied Keyword: Patch; Author-Supplied Keyword: Peel; Author-Supplied Keyword: Shear; Author-Supplied Keyword: Tack; Author-Supplied Keyword: Transdermal drug delivery system; Author-Supplied Keyword: Transdermal system; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ejpb.2006.03.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Culp, Sandra J.
AU - Mellick, Paul W.
AU - Trotter, Ronald W.
AU - Greenlees, Kevin J.
AU - Kodell, Ralph L.
AU - Beland, Frederick A.
T1 - Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/08//
VL - 44
IS - 8
M3 - Article
SP - 1204
EP - 1212
SN - 02786915
AB - Abstract: Malachite green is a triphenylmethane dye used in the fish industry as an anti-fungal agent. Leucomalachite green is formed by the metabolic reduction of malachite green and persists in the tissues of exposed fish. In this study, we examined the carcinogenicity of malachite green chloride and leucomalachite green. Female F344 rats (48 per group) were fed diets containing 0, 100, 300, or 600ppm malachite green chloride for 104 weeks, at which time the extent of tumorigenesis was assessed. Additional groups of 48 female and 48 male F344 rats were fed diets containing 0, 91, 272, or 543ppm leucomalachite green for 104 weeks. Groups of 48 female B6C3F1 mice were fed diets containing 0, 100, 225, or 450ppm malachite green chloride or 0, 91, 204, or 408ppm leucomalachite green for 104 weeks. For each of the exposures, food consumption in the treatment groups was similar to the controls. Rats fed malachite green chloride or leucomalachite green had dose-dependent reductions in body weight; in mice, there were no consistent effects upon body weights with either compound. Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma. Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia. In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis. There were no treatment-related neoplasms in female B6C3F1 mice fed malachite green chloride. Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALACHITE green
KW - VAT dyes
KW - TUMORS
KW - FOOD consumption
KW - NUTRITION
KW - HEALTH
KW - DIET
KW - Carcinogenesis
KW - direct exposure probe electron impact mass spectrometry ( DEP/EI/MS )
KW - high performance liquid chromatography ( HPLC )
KW - Leucomalachite green
KW - Malachite green
KW - National Toxicology Program ( NTP )
KW - nuclear magnetic resonance ( NMR )
N1 - Accession Number: 21340987; Culp, Sandra J. 1 Mellick, Paul W. 2 Trotter, Ronald W. 2 Greenlees, Kevin J. 3 Kodell, Ralph L. 4 Beland, Frederick A. 1; Email Address: frederick.beland@fda.hhs.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States 2: Pathology Associates International, National Center for Toxicological Research, Jefferson, AR 72079, United States 3: Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD 20855, United States 4: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, United States; Source Info: Aug2006, Vol. 44 Issue 8, p1204; Subject Term: MALACHITE green; Subject Term: VAT dyes; Subject Term: TUMORS; Subject Term: FOOD consumption; Subject Term: NUTRITION; Subject Term: HEALTH; Subject Term: DIET; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: direct exposure probe electron impact mass spectrometry ( DEP/EI/MS ); Author-Supplied Keyword: high performance liquid chromatography ( HPLC ); Author-Supplied Keyword: Leucomalachite green; Author-Supplied Keyword: Malachite green; Author-Supplied Keyword: National Toxicology Program ( NTP ); Author-Supplied Keyword: nuclear magnetic resonance ( NMR ); NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2006.01.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van Houtven, George
AU - Powers, John
AU - Jessup, Amber
AU - Yang, Jui-Chen
AD - RTI International
AD - US Environmental Protection Agency
AD - US Department of Health and Human Services
AD - RTI International
T1 - Valuing Avoided Morbidity Using Meta-regression Analysis: What Can Health Status Measures and QALYs Tell Us about WTP?
JO - Health Economics
JF - Health Economics
Y1 - 2006/08//
VL - 15
IS - 8
SP - 775
EP - 795
SN - 10579230
N1 - Accession Number: 0870069; Keywords: Health; Morbidity; QALY; Quality; Welfare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200611
N2 - Many economists argue that willingness-to-pay (WTP) measures are most appropriate for assessing the welfare effects of health changes. Nevertheless, the health evaluation literature is still dominated by studies estimating nonmonetary health status measures (HSMs), which are often used to assess changes in quality-adjusted life years (QALYs). Using meta-regression analysis, this paper combines results from both WTP and HSM studies applied to acute morbidity, and it tests whether a systematic relationship exists between HSM and WTP estimates. We analyze over 230 WTP estimates from 17 different studies and find evidence that QALY-based estimates of illness severity--as measured by the Quality of Well-Being (QWB) Scale--are significant factors in explaining variation in WTP, as are changes in the duration of illness and the average income and age of the study populations. In addition, we test and reject the assumption of a constant WTP per QALY gain. We also demonstrate how the estimated meta-regression equations can serve as benefit transfer functions for policy analysis. By specifying the change in duration and severity of the acute illness and the characteristics of the affected population, we apply the regression functions to predict average WTP per case avoided.
KW - Health Production I12
KW - General Welfare; Well-Being I31
L3 - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1050/issues
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UR - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1050/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Davis, Christopher C.
AU - Beard, Brian B.
AU - Tillman, Ahlia
AU - Rzasa, John
AU - Merideth, Eric
AU - Balzano, Quirino
T1 - International Intercomparison of Specific Absorption Rates in a Flat Absorbing Phantom in the Near-Field of Dipole Antennas.
JO - IEEE Transactions on Electromagnetic Compatibility
JF - IEEE Transactions on Electromagnetic Compatibility
Y1 - 2006/08//
VL - 48
IS - 3
M3 - Article
SP - 579
EP - 588
SN - 00189375
AB - This paper reports the results of an international intercomparison of the specific absorption rates (SARs) measured in a flat-bottomed container (flat phantom), filled with human head tissue simulant fluid, placed in the near-field of custom-built dipole antennas operating at 900 and 1800 MHz, respectively. These tests of the reliability of experimental SAR measurements have been conducted as part of a verification of the ways in which wireless phones are tested and certified for compliance with safety standards. The measurements are made using small electric-field probes scanned in the simulant fluid in the phantom to record the spatial SAR distribution. The intercomparison involved a standard flat phantom, antennas, power meters, and RF components being circulated among 15 different governmental and industrial laboratories. At the conclusion of each laboratory's measurements, the following results were communicated to the coordinators: Spatial SAR scans at 900 and 1800 MHz and 1 and 10 g maximum spatial SAR averages for cubic volumes at 900 and 1800 MHz. The overall results, given as meanstandard deviation, are the following: at 900 MHz, 1 g average 7.850.76; 10 g average 5.160.45; at 1800 MHz, 1 g average 18.44 ± 1.65; 10 g average 10.14 ± 0.85, all measured in units of watt per kilogram, per watt of radiated power. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Electromagnetic Compatibility is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHANTOMS (Radiology)
KW - TISSUES -- Models
KW - DIPOLE antennas
KW - ANTENNAS (Electronics)
KW - WIRELESS communication systems
KW - TELECOMMUNICATION
KW - FCC certification
KW - near-field antenna measurement
KW - specific absorption rate
KW - wireless phones.
N1 - Accession Number: 22225761; Davis, Christopher C. 1; Email Address: davis@eng.umd.edu Beard, Brian B. 2 Tillman, Ahlia 1,3 Rzasa, John 1 Merideth, Eric 4 Balzano, Quirino 1; Affiliation: 1: Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742 USA. 2: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20850 USA. 3: Integrated Defense Systems Division, Raytheon, Waltham, MA 02451 USA. 4: Lincoln Laboratory, Massachustts Institute of Technology, Lexington, MA 02420 USA.; Source Info: Aug2006, Vol. 48 Issue 3, p579; Subject Term: PHANTOMS (Radiology); Subject Term: TISSUES -- Models; Subject Term: DIPOLE antennas; Subject Term: ANTENNAS (Electronics); Subject Term: WIRELESS communication systems; Subject Term: TELECOMMUNICATION; Author-Supplied Keyword: FCC certification; Author-Supplied Keyword: near-field antenna measurement; Author-Supplied Keyword: specific absorption rate; Author-Supplied Keyword: wireless phones.; NAICS/Industry Codes: 423690 Other Electronic Parts and Equipment Merchant Wholesalers; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 237130 Power and Communication Line and Related Structures Construction; NAICS/Industry Codes: 811213 Communication Equipment Repair and Maintenance; NAICS/Industry Codes: 517919 All Other Telecommunications; NAICS/Industry Codes: 517911 Telecommunications Resellers; NAICS/Industry Codes: 517910 Other telecommunications; NAICS/Industry Codes: 334220 Radio and Television Broadcasting and Wireless Communications Equipment Manufacturing; NAICS/Industry Codes: 517210 Wireless Telecommunications Carriers (except Satellite); Number of Pages: 10p; Document Type: Article
L3 - 10.1109/TEMC.2006.877785
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mahajan, B.
AU - Noiva, R.
AU - Yadava, A.
AU - Zheng, H.
AU - Majam, V.
AU - Mohan, K.V. Krishna
AU - Moch, J.K.
AU - Haynes, J.D.
AU - Nakhasi, H.
AU - Kumar, S.
T1 - Protein disulfide isomerase assisted protein folding in malaria parasites
JO - International Journal for Parasitology
JF - International Journal for Parasitology
Y1 - 2006/08//
VL - 36
IS - 9
M3 - Article
SP - 1037
EP - 1048
SN - 00207519
AB - Abstract: In eukaryotes, the formation of protein disulfide bonds among cysteine residues is mediated by protein disulfide isomerases and occurs in the highly oxidised environment of the endoplasmic reticulum. This process is poorly understood in malaria parasites. In this paper, we report the gene isolation, sequence and phylogenetic comparisons, protein structure and thioredoxin-domain analyses of nine protein disulfide isomerases-like molecules from five species of malaria parasites including Plasmodium falciparum and Plasmodium vivax (human), Plasmodium knowlesi (simian) and Plasmodium berghei and Plasmodium yoelii (murine). Four of the studied protein disulfide isomerases belong to P. falciparum malaria and have been named PfPDI-8, PfPDI-9, PfPDI-11 and PfPDI-14, based on their chromosomal location. Among these, PfPDI-8 bears the closest similarity to a prototype PDI molecule with two thioredoxin domains (containing CGHC active sites) and a C-terminal Endoplasmic reticulum retrieval signal, SEEL. PfPDI-8 is expressed during all stages of parasite life cycle and is highly conserved (82–96% identity at amino acid level) in the other four Plasmodium species studied. Detailed biochemical analysis of PfPDI-8 revealed that this molecule is a potent oxido-reductase enzyme that facilitated the disulfide-dependent conformational folding of EBA-175, a leading malaria vaccine candidate. These studies open the avenues to understand the process of protein folding and secretory pathway in malaria parasites that in turn might aid in the production of superior recombinant vaccines and provide novel drug targets. [Copyright &y& Elsevier]
AB - Copyright of International Journal for Parasitology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN disulfide isomerase
KW - PROTEIN folding
KW - PARASITES
KW - MALARIA
KW - EBA-175
KW - Folding
KW - Plasmodium falciparum
KW - Protein disulfide isomerase
N1 - Accession Number: 21741787; Mahajan, B. 1 Noiva, R. 2 Yadava, A. 3 Zheng, H. 1 Majam, V. 1 Mohan, K.V. Krishna 4 Moch, J.K. 3 Haynes, J.D. 3 Nakhasi, H. 1 Kumar, S. 1; Email Address: sanjai.kumar@fda.hhs.gov; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20895, USA 2: Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57069, USA 3: Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA 4: Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20895, USA; Source Info: Aug2006, Vol. 36 Issue 9, p1037; Subject Term: PROTEIN disulfide isomerase; Subject Term: PROTEIN folding; Subject Term: PARASITES; Subject Term: MALARIA; Author-Supplied Keyword: EBA-175; Author-Supplied Keyword: Folding; Author-Supplied Keyword: Plasmodium falciparum; Author-Supplied Keyword: Protein disulfide isomerase; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ijpara.2006.04.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whiting, R.C.
AU - Rainosek, A.
AU - Buchanan, R.L.
AU - Miliotis, M.
AU - LaBarre, D.
AU - Long, W.
AU - Ruple, A.
AU - Schaub, S.
T1 - Determining the microbiological criteria for lot rejection from the performance objective or food safety objective
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2006/08//
VL - 110
IS - 3
M3 - Article
SP - 263
EP - 267
SN - 01681605
AB - Abstract: The Microbiological Criteria (MC) is a set of parameters used to determine whether a specific lot of food is acceptable or not. These parameters are the microbial test protocol and its sensitivity, the confidence level that an unacceptable lot will be detected, the number of samples to be taken and the number of positive samples that are allowed before rejecting the lot. Determining the microbiological criteria begins with knowledge of the distribution of contamination from samples within a lot, particularly within a lot that is just at the unacceptable level of the microbial hazard. The just unacceptable lot can be defined by the Food Safety Objective (FSO) or Performance Objectives (PO), the small fraction of samples that can exceed these values and the standard deviation of the samples from the lot. With this information, a microbial test protocol is chosen to have a sensitivity level that would detect between approximately 15% and 45% of the samples. A confidence level for the MC and the number of positive samples that would be acceptable (c value which is usually zero) are also chosen. With this information the number of samples (n) required can be calculated. A critical factor in setting the microbiological criteria is the sensitivity of the microbiological test (m value). The sample size (weight) and sampling procedure can affect the standard deviation of the samples, particularly foods with non-homogeneous distribution and low numbers of microorganisms. Sampling, sample preparation and analytical procedures that reduce the variation between the samples will affect the choice of m value and maximum lot mean that meets the MC. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Safety measures
KW - Microbiological assay
KW - Microorganisms
KW - Food industry
KW - Attribute testing
KW - Risk analysis
KW - Risk assessment
N1 - Accession Number: 21738380; Whiting, R.C. 1; Email Address: richard.whiting@fda.hhs.gov; Rainosek, A. 2; Buchanan, R.L. 1; Miliotis, M. 1; LaBarre, D. 3; Long, W. 1; Ruple, A. 4; Schaub, S. 5; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA; 2: Department of Mathematics and Statistics, University of South Alabama, Mobile, AL 36688, USA; 3: Food Safety and Inspection Service, Department of Agriculture, Washington, DC 20250, USA; 4: National Oceanographic and Atmospheric Administration, Fisheries, Pascagoula, MS 39568, USA; 5: Environmental Protection Agency, Washington, DC 20460, USA; Issue Info: Aug2006, Vol. 110 Issue 3, p263; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Microbiological assay; Thesaurus Term: Microorganisms; Thesaurus Term: Food industry; Author-Supplied Keyword: Attribute testing; Author-Supplied Keyword: Risk analysis; Author-Supplied Keyword: Risk assessment; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2006.04.038
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Finkelman, Malcolm A.
AU - Lempitski, Steven J.
AU - Slater, Jay E.
T1 - β-Glucans in standardized allergen extracts.
JO - Journal of Endotoxin Research
JF - Journal of Endotoxin Research
Y1 - 2006/08//
VL - 12
IS - 4
M3 - Article
SP - 241
EP - 245
PB - Sage Publications, Ltd.
SN - 09680519
AB - Background: Allergen extracts contain variable quantities of bacterial endotoxin. Recent studies have suggested that (1→3)-β-D-glucans (β-glucans), also microbial cell wall components, may have adjuvant properties that could affect allergen immunotherapy. Objective: To determine the quantities of β-glucans in standardized allergen extracts. Materials and Methods: Ninety-four lots of 13 standardized allergen extracts were tested for β-glucan content by Glucatell assay, and for endotoxin content by a specific, chromogenic formulation of the Limulus amebocyte lysate test. Results: Standardized allergen extracts contain variable quantities of endotoxins and β-glucans. As in our previous work, endotoxin activity was greatest in cat pelt and Dermatophagoides farinae, and least in the pollens. There was no correlation between endotoxin and β-glucan levels (r = 0.1887; P = 0.07). β-Glucan content was highest for grass pollen (median content, 10.6 ng/ml; range, 0.4–41.8 ng/ml), ragweed pollen (32.9 ng/ml; range, 6.5–41.2 ng/ml), and cat pelt (25.5 ng/ml; range, 16.7–41.1 ng/ml), and lowest for cat hair (4.9 ng/ml; range, 1.2–10.3 ng/ml), D. farinae (1.2 ng/ml; range, 0.4–5.2 ng/ml) and Dermatophagoides pteronyssinus (1.8 ng/ml; range, 0.4–6.7 ng/ml). Conclusions: β-Glucans are present in standardized allergen extracts. The effects of these quantities of β-glucans on allergen immunotherapy and allergen skin testing require further study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Endotoxin Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Antigens
KW - Endotoxins
KW - Glucans
KW - Pollen
KW - Immunotherapy
KW - β-Glucan
KW - allergen extracts
KW - allergen immunotherapy
KW - allergen standardization
KW - BETA-GLUCAN
KW - endotoxin
N1 - Accession Number: 22091147; Finkelman, Malcolm A. 1; Lempitski, Steven J. 1; Slater, Jay E. 2; Email Address: jay.slater@fda.hhs.gov; Affiliations: 1: Associates of Cape Cod, East Falmouth, Massachusetts, USA; 2: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA; Issue Info: 2006, Vol. 12 Issue 4, p241; Thesaurus Term: Allergens; Thesaurus Term: Antigens; Thesaurus Term: Endotoxins; Thesaurus Term: Glucans; Thesaurus Term: Pollen; Subject Term: Immunotherapy; Author-Supplied Keyword: β-Glucan; Author-Supplied Keyword: allergen extracts; Author-Supplied Keyword: allergen immunotherapy; Author-Supplied Keyword: allergen standardization; Author-Supplied Keyword: BETA-GLUCAN; Author-Supplied Keyword: endotoxin; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1179/096805106X102237
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jhoo, J.-W.
AU - Freeman, J. P.
AU - Ang, C. Y. W.
AU - Mihalov, J. J.
T1 - Assessment of Kavalactones in Kava Beverage Products and Aqueous Infusions.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2006/08//
VL - 71
IS - 6
M3 - Article
SP - C345
EP - C351
SN - 00221147
AB - The article presents a study which developed analytical methods to assess kavalactone content in functional beverage products with kava and beverages prepared from kava roots by a traditional method involving infusion with water. Solid-phase or liquid-liquid extraction was used to prepare samples of fruit-flavored beverages to remove interfering substances. It was found that kava beverages prepared fresh by water infusion had much higher levels of kavalactones than the commercial products.
KW - KAVA (Beverage)
KW - SALTWATER solutions
KW - BEVERAGES
KW - KAVA plant
KW - PRODUCT safety
N1 - Accession Number: 63004358; Jhoo, J.-W. 1; Email Address: jjhoo@kangwon.ac.kr Freeman, J. P. 1; Email Address: jjhoo@kangwon.ac.kr Ang, C. Y. W. 1; Email Address: jjhoo@kangwon.ac.kr Mihalov, J. J. 1; Email Address: jjhoo@kangwon.ac.kr; Affiliation: 1: Authors Jhoo, Freeman, and Ang are with National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, U.S.A. Author Jhoo is with Kangwon National Univ, Dept. of Food Science and Technology in Animal Resources,192-1 Hyoja-2, Chunchon, Kangwon, South Korea 200-701. Author Mihalov is with Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, U.S.A. Direct inquiries to author Jhoo (E-mail: ).; Source Info: Aug2006, Vol. 71 Issue 6, pC345; Subject Term: KAVA (Beverage); Subject Term: SALTWATER solutions; Subject Term: BEVERAGES; Subject Term: KAVA plant; Subject Term: PRODUCT safety; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1750-3841.2006.00102.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Edelson-Mammel, S.
AU - Porteous, M.K.
AU - Buchanan, R.L.
T1 - Acid Resistance of Twelve Strains of Enterobacter sakazakii, and the Impact of Habituating the Cells to an Acidic Environment.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2006/08//
VL - 71
IS - 6
M3 - Article
SP - M201
EP - M207
SN - 00221147
AB - The article presents a study which examined the stationary-phase acid resistance of the Enterobacter sakazakii using 12 strains that had been used to characterize its thermal resistance. The 12 strains were grown by inoculating sterile test tubes with 10 milliliters (mL) of brain heart infusion broth and incubating the cultures without agitation for 18 hours at 36 degree Centigrade. No apparent relationship existed between the acid resistance of individual strains and their thermal resistance.
KW - ENTEROBACTER
KW - INFECTION
KW - MICROBIOLOGY
KW - STATIONARY phase (Chromatography)
KW - ENTEROBACTERIACEAE
N1 - Accession Number: 63004344; Edelson-Mammel, S. 1; Email Address: robert.buchanan@fda.hhs.gov Porteous, M.K. 1; Email Address: robert.buchanan@fda.hhs.gov Buchanan, R.L. 1; Email Address: robert.buchanan@fda.hhs.gov; Affiliation: 1: Authors Edelson-Mammel and Buchanan are with DHHS Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Md., U.S.A. Author Porteous is with Univ. of Maryland, College Park, Md., U.S.A. Direct inquiries to author Buchanan (E-mail: ).; Source Info: Aug2006, Vol. 71 Issue 6, pM201; Subject Term: ENTEROBACTER; Subject Term: INFECTION; Subject Term: MICROBIOLOGY; Subject Term: STATIONARY phase (Chromatography); Subject Term: ENTEROBACTERIACEAE; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1750-3841.2006.00101.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boeniger, Mark
T1 - A Comparison of Surface Wipe Media for Sampling Lead on Hands.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/08//
VL - 3
IS - 8
M3 - Article
SP - 428
EP - 434
PB - Taylor & Francis Ltd
SN - 15459624
AB - Hand contamination by toxic agents such as lead presents a potentially significant health hazard to workers if the contamination is transferred to the mouth by food, smoking, or touching the mouth. One method to sample the mass of contamination on hands is to wipe the skin and analyze the wipe media for the analyte. Several commercially available, prewetted wipe media were evaluated and compared. The Palintest and Wash'n Dri media are made of cellulose fiber; the Ghost wipe is made of a nonwoven polyvinyl alcohol fiber. ASTM test method E1792 for surface lead sampling provides some specified minimum requirements and some general, nonspecific criteria that these media should meet. However, no objective determination of the performance or characteristics of these different wiping media were found in the open literature for sampling lead on hands, particularly relating to typical collection efficiency. To test the recovery of lead oxide dust collected from two hands, two different loading levels were used for each wipe medium. Four successive wipes were collected and analyzed individually. The results of this study indicate that only about 52-62% of the total lead loading is recovered with the first wipe, but that up to 75% recovery could be obtained by combining all three successive wipes. This study also describes testing several physical aspects of these wipes that included tensile strength, wetness, and drying rate, which are characteristics that are not specified by ASTM E1792. The results indicate a higher fragility among the cellulosic wipes, less moisture content, and higher drying rates than the Ghost wipe. This information should be helpful when selecting a wipe material that is best suited for an environmental or industrial hygiene surface or skin sampling task and might also be useful for improving such media in the future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbial contamination
KW - Comparative studies
KW - Health risk assessment
KW - Industrial hygiene
KW - Wiping cloths
KW - Cellulose fibers
KW - hand wipes
KW - lead
KW - sampling
N1 - Accession Number: 53046493; Boeniger, Mark 1; Email Address: mfboeniger@worldnet.att.net; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Aug2006, Vol. 3 Issue 8, p428; Thesaurus Term: Microbial contamination; Thesaurus Term: Comparative studies; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial hygiene; Subject Term: Wiping cloths; Subject Term: Cellulose fibers; Author-Supplied Keyword: hand wipes; Author-Supplied Keyword: lead; Author-Supplied Keyword: sampling; NAICS/Industry Codes: 325220 Artificial and Synthetic Fibers and Filaments Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15459620600802754
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106210874
T1 - A comparison of surface wipe media for sampling lead on hands.
AU - Boeniger M
Y1 - 2006/08//
N1 - Accession Number: 106210874. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D77-8. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Environmental -- Analysis
KW - Dust -- Analysis
KW - Environmental Monitoring -- Equipment and Supplies
KW - Hand
KW - Lead -- Analysis
KW - Occupational Exposure -- Analysis
KW - Oxides -- Analysis
KW - Comparative Studies
KW - Education, Continuing (Credit)
KW - Human
KW - Mann-Whitney U Test
KW - One-Way Analysis of Variance
KW - Reliability
KW - Textiles
SP - 428
EP - 434
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Hand contamination by toxic agents such as lead presents a potentially significant health hazard to workers if the contamination is transferred to the mouth by food, smoking, or touching the mouth. One method to sample the mass of contamination on hands is to wipe the skin and analyze the wipe media for the analyte. Several commercially available, prewetted wipe media were evaluated and compared. The Palintest and Wash'n Dri media are made of cellulose fiber; the Ghost wipe is made of a nonwoven polyvinyl alcohol fiber. ASTM test method E1792 for surface lead sampling provides some specified minimum requirements and some general, nonspecific criteria that these media should meet. However, no objective determination of the performance or characteristics of these different wiping media were found in the open literature for sampling lead on hands, particularly relating to typical collection efficiency. To test the recovery of lead oxide dust collected from two hands, two different loading levels were used for each wipe medium. Four successive wipes were collected and analyzed individually. The results of this study indicate that only about 52-62% of the total lead loading is recovered with the first wipe, but that up to 75% recovery could be obtained by combining all three successive wipes. This study also describes testing several physical aspects of these wipes that included tensile strength, wetness, and drying rate, which are characteristics that are not specified by ASTM E1792. The results indicate a higher fragility among the cellulosic wipes, less moisture content, and higher drying rates than the Ghost wipe. This information should be helpful when selecting a wipe material that is best suited for an environmental or industrial hygiene surface or skin sampling task and might also be useful for improving such media in the future.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH; mfboeniger@worldnet.att.net
U2 - PMID: 16862713.
DO - 10.1080/15459620600802754
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mahmood, Iftekhar
T1 - Prediction of human drug clearance from animal data: Application of the rule of exponents and ‘fu corrected intercept method’ (FCIM).
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/08//
VL - 95
IS - 8
M3 - Article
SP - 1810
EP - 1821
SN - 00223549
AB - The objective of this study is to evaluate the predictive performance of the rule of exponents (ROE) and ‘fu Corrected Intercept Method’ (FCIM) for the human drug clearance. Different classes of drugs such as extensively metabolized, renally excreted, renally secreted, and biliary excreted drugs were used in this analysis. The results of the study indicated that both these methods under given conditions are extremely useful for the prediction of human drug clearance. There are certain situations under which one of these methods is more suited than the other method. Overall, it appears that a rational use of FCIM and the ROE can help a great deal in obtaining a better estimate of the human drug clearance for a wide variety of drugs. The advantages and disadvantages of these two methods are also discussed. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1810–1821, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
KW - DRUG development
KW - PHARMACOLOGY
KW - allometric scaling
KW - biliary excretion
KW - clearance
KW - preclinical pharmacokinetics
KW - protein binding
KW - renal clearance
KW - vertical allometry
N1 - Accession Number: 22171390; Mahmood, Iftekhar 1; Email Address: Mahmoodi@CDER.FDA.GOV; Affiliation: 1: Clinical Pharmacology and Toxicology Branch (HFD-579), Office of Drug Evaluation VI, Center for Drug Evaluation and Research, Food & Drug Administration, Woodmont Office Center II, Rockville, Maryland 20852; Source Info: Aug2006, Vol. 95 Issue 8, p1810; Subject Term: DRUGS; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Subject Term: DRUG development; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: allometric scaling; Author-Supplied Keyword: biliary excretion; Author-Supplied Keyword: clearance; Author-Supplied Keyword: preclinical pharmacokinetics; Author-Supplied Keyword: protein binding; Author-Supplied Keyword: renal clearance; Author-Supplied Keyword: vertical allometry; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1002/jps.20650
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kiley, James P.
AU - Frumkin, Howard
AU - Collins, Janet L.
AU - Price, Deborah A.
T1 - Foreword.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2006/08//
VL - 76
IS - 6
M3 - Letter
SP - 201
EP - 201
PB - Wiley-Blackwell
SN - 00224391
AB - The article presents a foreword to the August 2006 issue of the "Journal of School Health." The issue focuses on children who have asthma and school-based asthma programs. More than 5 million school children in the United States have asthma, and improperly controlled asthma is credited with almost 15 million absences annually. In addition, asthma can compromise academic performance and limit participation in school activities and sports, making it essential for schools to manage asthma programs and minimize negative effects.
KW - ASTHMA
KW - CHILDREN -- United States
KW - SCHOOL children
KW - PUBLIC health
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 21980230; Kiley, James P. 1 Frumkin, Howard 2 Collins, Janet L. 3 Price, Deborah A. 4; Affiliation: 1: Director Division of Lung Diseases National Heart, Lung and Blood Institute National Institutes for Health 2: Director National Center for Environmental Health/Agency for Toxic Substances and Disease Registry Centers for Disease Control and Prevention US Department of Health and Human Services 3: Director National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention 4: Assistant Deputy Secretary Office of Safe and Drug-Free Schools US Department of Education; Source Info: Aug2006, Vol. 76 Issue 6, p201; Subject Term: ASTHMA; Subject Term: CHILDREN -- United States; Subject Term: SCHOOL children; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Document Type: Letter; Full Text Word Count: 317
L3 - 10.1111/j.1746-1561.2006.00095.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xu, Hockin H. K.
AU - Takagi, Shozo
AU - Sun, Limin
AU - Hussain, Latiff
AU - Chow, Laurence C.
AU - Guthrie, William F.
AU - Yen, James H.
T1 - Development of a nonrigid, durable calcium phosphate cement for use in periodontal bone repair.
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2006/08//
VL - 137
IS - 8
M3 - Article
SP - 1131
EP - 1138
SN - 00028177
AB - The article focuses on the development of a strong and nonrigid calcium phosphate cement (CPC) to provide compliance for tooth mobility in performing periodontal repair. Tetracalcium phosphate, dicalcium phosphate anhydrous and biopolymer chitosan were used to develop a reliable CPC. Findings in the study revealed that the nonrigid cement consisting of nanohydroxyapatite crystals possessed a high ductility and superior fracture resistance.
KW - DENTISTRY
KW - PERIODONTAL disease -- Treatment
KW - TEETH -- Mobility
KW - DENTAL materials
KW - CALCIUM phosphate
KW - DENTAL care
KW - calcium phosphate cement
KW - nanohydroxyapatite crystals
KW - nonrigidity
KW - Periodontal bone repair
N1 - Accession Number: 22185008; Xu, Hockin H. K. 1; Email Address: hockin.xu@nist.gov Takagi, Shozo 2 Sun, Limin 3 Hussain, Latiff 4 Chow, Laurence C. 5 Guthrie, William F. 6 Yen, James H. 6; Affiliation: 1: Senior Project Leader, Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8546, Gaithersburg 2: Senior Project Leader, Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg 3: Postdoctoral Fellow, Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg 4: Member of the Research Staff. U.S. Food and Drug Administration, Rockville 5: Chief Scientist, Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology. Gaithersburg 6: Statistician, Statistical Engineering Division, National Institute of Standards and Technology. Gaithersburg; Source Info: Aug2006, Vol. 137 Issue 8, p1131; Subject Term: DENTISTRY; Subject Term: PERIODONTAL disease -- Treatment; Subject Term: TEETH -- Mobility; Subject Term: DENTAL materials; Subject Term: CALCIUM phosphate; Subject Term: DENTAL care; Author-Supplied Keyword: calcium phosphate cement; Author-Supplied Keyword: nanohydroxyapatite crystals; Author-Supplied Keyword: nonrigidity; Author-Supplied Keyword: Periodontal bone repair; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHIESA, O. A.
AU - VON BREDOW, J.
AU - SMITH, M.
AU - HELLER, D.
AU - CONDON, R.
AU - THOMAS, M. H.
T1 - Bovine kidney tissue/biological fluid correlation for penicillin.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/08//
VL - 29
IS - 4
M3 - Article
SP - 299
EP - 306
PB - Wiley-Blackwell
SN - 01407783
AB - Penicillin is one of the most commonly misused drugs in steers and dairy cows. In the US, at slaughter the tolerance is 50 ng/g in kidney and other edible tissues. If the tolerance is exceeded, the carcass may not be used for human food. A preslaughter test for penicillin in an easily accessible biological fluid is needed to predict if the concentration of penicillin is below tolerance in the kidney before the bovine is slaughtered. In this study, 12 steers were injected three times with the approved dose (7000 IU) of penicillin at 12-h intervals. Blood and urine samples were collected at intervals after the final dose of penicillin. At each sampling point, one kidney biopsy sample was collected by laparoscopic surgery in the live animal. Another kidney sample was collected at slaughter. Correlations between plasma and kidney concentrations and between urine and kidney concentrations were determined. These correlations predict with 95% confidence that 99% of the animals will have kidney tissue below penicillin tolerance when the plasma concentration of penicillin is below 0.4 ng/mL and/or the urine penicillin concentration is below 140 ng/mL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBACTERIAL agents
KW - PENICILLIN
KW - BEEF cattle
KW - COWS
KW - KIDNEYS
N1 - Accession Number: 21385013; CHIESA, O. A. 1; Email Address: ochiesa@cvm.fda.gov VON BREDOW, J. 1 SMITH, M. 1 HELLER, D. 1 CONDON, R. 2 THOMAS, M. H. 1; Affiliation: 1: Division of Residue Chemistry, Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA 2: FDA Statistics contractor, Myersville, MD, USA; Source Info: Aug2006, Vol. 29 Issue 4, p299; Subject Term: ANTIBACTERIAL agents; Subject Term: PENICILLIN; Subject Term: BEEF cattle; Subject Term: COWS; Subject Term: KIDNEYS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112110 Beef cattle ranching and farming, including feedlots; NAICS/Industry Codes: 112111 Beef Cattle Ranching and Farming; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00747.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106337448
T1 - Meeting the health literacy needs of clients.
AU - Wilson J
Y1 - 2006/08//
N1 - Accession Number: 106337448. Language: English. Entry Date: 20060922. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Australia & New Zealand; Editorial Board Reviewed; Nursing; Peer Reviewed. NLM UID: 9507374.
KW - Interpreter Services -- Utilization
KW - Health Literacy
KW - Community Health Nursing
KW - Health Services Accessibility
KW - Literacy
KW - New Zealand
KW - Surveys
SP - 18
EP - 19
JO - Kai Tiaki Nursing New Zealand
JF - Kai Tiaki Nursing New Zealand
JA - KAI TIAKI NURS NZ
VL - 12
IS - 7
PB - New Zealand Nurses Organisation
AB - Nurses have a responsibility to ensure their non-English speaking clients understand basic health information. Using a professional interpreter can be the best way to facilitate this.
SN - 1173-2032
AD - Co-ordinator of Communicable Disease Nursing, Refugee Health Adviser, Hutt Valley District Health Board's Regional Public Health Service
U2 - PMID: 17076295.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lipshultz, Steven E.
AU - Cohen, Harvey
AU - Colan, Steven D.
AU - Herman, Eugene H.
T1 - The relevance of information generated by in vitro experimental models to clinical doxorubicin cardiotoxicity.
JO - Leukemia & Lymphoma
JF - Leukemia & Lymphoma
Y1 - 2006/08//
VL - 47
IS - 8
M3 - Article
SP - 1454
EP - 1458
PB - Taylor & Francis Ltd
SN - 10428194
AB - The article features commentary on the analysis of the in vitro pharmacodynamics of a continuous infusion of doxorubicin. It is reported that the anti-leukemia and cardiotoxic effects of doxorubicin are dependent on peak serum concentration and Continuous infusions may reduce cardiotoxicity with only a minimal reduction in anti-cancer effect. The article explains the descripencies in these studies and maintains that it will not have clinical importance for lack of support from clinical trials.
KW - DOXORUBICIN
KW - PHARMACOKINETICS
KW - DRUGS -- Dose-response relationship
KW - CLINICAL medicine -- Research
N1 - Accession Number: 22297022; Lipshultz, Steven E. 1; Email Address: slipshultz@med.miami.edu Cohen, Harvey 2 Colan, Steven D. 3 Herman, Eugene H. 4; Affiliation: 1: Department of Pediatrics, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, USA 2: Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA 3: Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA, USA 4: Food and Drug Administration, Division of Applied Pharmacology Research (HFD-910), Silver Spring, MD, USA; Source Info: Aug2006, Vol. 47 Issue 8, p1454; Subject Term: DOXORUBICIN; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Dose-response relationship; Subject Term: CLINICAL medicine -- Research; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/10428190600800231
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22297022&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106141805
T1 - Healthcare utilization and outcomes after bariatric surgery.
AU - Encinosa WE
AU - Bernard DM
AU - Chen C
AU - Steiner CA
Y1 - 2006/08//
N1 - Accession Number: 106141805. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Hawn MT. Treating obesity: there is no free lunch. (MED CARE) Aug2006; 44 (8): 703-705. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality. NLM UID: 0230027.
KW - Bariatric Surgery
KW - Health Resource Utilization
KW - Insurance
KW - Postoperative Complications -- Epidemiology
KW - Adolescence
KW - Adult
KW - Descriptive Statistics
KW - Exploratory Research
KW - Female
KW - Funding Source
KW - Male
KW - Middle Age
KW - Outcomes Research
KW - P-Value
KW - Regression
KW - United States
KW - Human
SP - 706
EP - 712
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 44
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Bariatric surgery is one of the fastest growing hospital procedures. Our objective is to examine the safety outcomes and utilization of resources in the 6 months after bariatric surgery using a nationwide, population-based sample.DATA/DESIGN: We examine insurance claims for 2522 bariatric surgeries, at 308 hospitals, among a population of 5.6 million nonelderly people covered by large employers in the 2001-2002 MarketScan data. Outcomes and costs were risk-adjusted using multivariate regression methods.PRINCIPAL FINDINGS: Although the complication rate was 21.9% during the initial surgical stay, the rate increased by 81% (P < 0.01) to 39.6% (95% confidence interval, 37.7-41.5%) over the 180 days after discharge. A total of 10.8% of the patients without 30-day complications developed a complication between 30 days and 180 days. Overall, 18.2% of the patients had some type of postoperative visit to the hospital with a complication (through readmission, outpatient hospital visit, or emergency room visit) within 180 days. Although there was no difference between men and women, the near-elderly had a 26% (P < 0.01) higher risk-adjusted complication rate than those age 18 to 39 years. Total 6-month risk-adjusted healthcare payments were $65,031 for those with 180-day readmissions compared with $27,125 for those without readmissions (P < 0.01).CONCLUSION: In contrast to current bariatric studies, which report a 20% in-hospital complication rate, we find a significantly higher complication rate over the 6 months after surgery, resulting in costly readmissions and emergency room visits. Thus, a clear way to reduce the costs and improve outcomes of bariatric surgery is to address the high rate of postoperative complications.
SN - 0025-7079
AD - Center for Delivery, Organization and Markets, Rockville, Maryland
U2 - PMID: 16862031.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106141805&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Gottlieb, Scott
AU - Woodcock, Janet
T1 - A regulatory perspective on in vitro diagnostics.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/08//
VL - 24
IS - 8
M3 - Editorial
SP - 927
EP - 929
SN - 10870156
AB - The article reports that the U.S. FDA has initiated efforts to employ the knowledge of experts in industry and academia to better enable it to make regulatory decisions around new diagnostic tests. The FDA regulates IVD devices in accordance with the device provisions of the US Federal Food, Drug and Cosmetic Act. One of the most efficient approaches would be to create a drug and the corresponding diagnostic test during the same development program.
KW - Diagnosis
KW - Decision making
KW - Government agencies
KW - Pharmaceutical industry
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 21944817; Gottlieb, Scott 1; Woodcock, Janet 2; Affiliations: 1: Deputy Commissioner for Medical and Scientific Affairs, US Food and Drug Administration, Rockville, Maryland 20857, USA.; 2: Deputy Commissioner for Operations, US Food and Drug Administration, Rockville, Maryland 20857, USA.; Issue Info: Aug2006, Vol. 24 Issue 8, p927; Subject Term: Diagnosis; Subject Term: Decision making; Subject Term: Government agencies; Subject Term: Pharmaceutical industry; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1038/nbt0806-927
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Trumbo, Paula R.
AU - Ellwood, Kathleen C.
T1 - Chromium Picolinate Intake and Risk of Type 2 Diabetes: An Evidence-Based Review by the United States Food and Drug Administration.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2006/08//
VL - 64
IS - 8
M3 - Article
SP - 357
EP - 363
SN - 00296643
AB - The labeling of both health claims that meet significant scientific agreement (SSA) and qualified health claims on conventional foods and dietary supplements requires pre-market approval by the US Food and Drug Administration (FDA). Approval by the FDA involves, in part, a thorough review of the scientific evidence to support an SSA or a qualified health claim. This article discusses FDA's evidence-based review of the scientific evidence on the role of chromium picolinate supplements in reducing the risk of type 2 diabetes. Based on this evidence-based review, FDA issued a letter of enforcement discretion for one qualified health claim on chromium picolinate and risk of insulin resistance, a surrogate endpoint for type 2 diabetes. The agency concluded that the relationship between chromium picolinate intake and insulin resistance is highly uncertain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hormones
KW - Dietary supplements
KW - Chromium
KW - Non-insulin-dependent diabetes
KW - Diabetes -- Complications
KW - Endocrine diseases
KW - Insulin resistance
KW - Hypoglycemic agents
KW - chromium picolinate
KW - diabetes
KW - health claims
KW - type 2 diabetes
KW - United States. Food & Drug Administration
N1 - Accession Number: 21888143; Trumbo, Paula R. 1; Email Address: Paula.Trumbo@FDA.gov; Ellwood, Kathleen C. 1; Affiliations: 1: Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, Maryland; Issue Info: Aug2006, Vol. 64 Issue 8, p357; Thesaurus Term: Hormones; Thesaurus Term: Dietary supplements; Thesaurus Term: Chromium; Subject Term: Non-insulin-dependent diabetes; Subject Term: Diabetes -- Complications; Subject Term: Endocrine diseases; Subject Term: Insulin resistance; Subject Term: Hypoglycemic agents; Author-Supplied Keyword: chromium picolinate; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: health claims; Author-Supplied Keyword: type 2 diabetes ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1301/nr.2006.aug.357-363
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106342262
T1 - Chromium picolinate intake and risk of type 2 diabetes: an evidence-based review by the United States Food and Drug Administration.
AU - Trumbo PR
AU - Ellwood KC
Y1 - 2006/08//
N1 - Accession Number: 106342262. Language: English. Entry Date: 20061006. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Chromium -- Administration and Dosage
KW - Dietary Supplementation
KW - Diabetes Mellitus, Type 2 -- Prevention and Control
KW - Product Labeling
KW - Consumer Health Information
KW - United States Food and Drug Administration
KW - Professional Practice, Evidence-Based
KW - United States
KW - Insulin Resistance
KW - Glucose -- Metabolism
KW - Blood Glucose -- Drug Effects
SP - 357
EP - 363
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 64
IS - 8
PB - Oxford University Press / USA
SN - 0029-6643
AD - Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, Maryland; Paula.Trumbo@FDA.gov
U2 - PMID: 16958312.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Henneberger, P. K.
AU - Derk, S. J.
AU - Sama, S. R.
AU - Boylstein, R. J.
AU - Hoffman, C. D.
AU - Preusse, P. A.
AU - Rosiello, R. A.
AU - Milton, D. K.
T1 - The frequency of workplace exacerbation among health maintenance organisation members with asthma.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2006/08//
VL - 63
IS - 8
M3 - Article
SP - 551
EP - 557
SN - 13510711
AB - Objectives: Workplace conditions can potentially contribute to the worsening of asthma, yet it is unclear what percentage of adults with asthma experience workplace exacerbation of symptoms. The objective of this investigation was to determine the prevalence of workplace exacerbation of asthma (WEA). Methods: Adults with asthma aged 18–44 were enrolled into the baseline survey of a longitudinal study. Members of a health maintenance organisation were considered candidates for participation if they fulfilled membership, diagnostic, and treatment criteria based on automated review of electronic billing, claims, and pharmacy records. Diagnosis and treatment were confirmed by manual review of medical records. A telephone questionnaire was administered. A work related symptom score was assigned to each participant based on responses to questions about work related asthma symptoms, medication use, and symptom triggers. Blinded to participants' answers to these questions, two researchers independently reviewed the self-reported work histories and assigned exposure ratings. A final exposure score was then calculated. Participants with sufficient evidence for work related symptoms and exposure were classified as having WEA. Results: Of the 598 participants with complete data, 557 (93%) were working, and 136 (23%) fulfilled the criteria for WEA. Those with WEA were more likely to be male and to report that they had been bothered by asthma symptoms during the past seven days. Conclusions: Workplace exacerbation of asthma was common in this study population, occurring in over a fifth of these adults with asthma. Physicians should consider that work can contribute to the exacerbation of symptoms when treating adults with asthma. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Asthmatics
KW - Work environment
KW - Health maintenance organizations
KW - Invoices
KW - Claims
KW - Pharmacy
KW - Medical care
KW - Drug utilization
N1 - Accession Number: 21928304; Henneberger, P. K. 1; Email Address: pkh0@cdc.gov; Derk, S. J. 1; Sama, S. R. 2; Boylstein, R. J. 1; Hoffman, C. D. 1; Preusse, P. A. 3; Rosiello, R. A. 3; Milton, D. K. 4; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA; 2: Fallon Clinic, Worcester, MA, USA; 3: Fallon Clinic Research Department, Worcester, MA, USA; 4: Department of Work Environment, University of Massachusetts, Lowell, MA, USA; Issue Info: Aug2006, Vol. 63 Issue 8, p551; Thesaurus Term: Asthma; Subject Term: Asthmatics; Subject Term: Work environment; Subject Term: Health maintenance organizations; Subject Term: Invoices; Subject Term: Claims; Subject Term: Pharmacy; Subject Term: Medical care; Subject Term: Drug utilization; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 7p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1136/oem.2005.024786
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106273996
T1 - The frequency of workplace exacerbation among health maintenance organisation members with asthma.
AU - Henneberger PK
AU - Derk SJ
AU - Sama SR
AU - Boylstein RJ
AU - Hoffman CD
AU - Preusse PA
AU - Rosiello RA
AU - Milton DK
Y1 - 2006/08//
N1 - Accession Number: 106273996. Language: English. Entry Date: 20070427. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Asthma -- Etiology
KW - Health Maintenance Organizations
KW - Occupational Diseases -- Etiology
KW - Adolescence
KW - Adult
KW - Bias (Research)
KW - Chi Square Test
KW - Descriptive Statistics
KW - Female
KW - Interviews
KW - Male
KW - Prospective Studies
KW - Questionnaires
KW - Record Review
KW - Statistical Significance
KW - Surveys
KW - T-Tests
KW - Telephone
KW - Work Environment
KW - Human
SP - 551
EP - 557
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 63
IS - 8
PB - BMJ Publishing Group
AB - OBJECTIVES: Workplace conditions can potentially contribute to the worsening of asthma, yet it is unclear what percentage of adults with asthma experience workplace exacerbation of symptoms. The objective of this investigation was to determine the prevalence of workplace exacerbation of asthma (WEA). METHODS: Adults with asthma aged 18-44 were enrolled into the baseline survey of a longitudinal study. Members of a health maintenance organisation were considered candidates for participation if they fulfilled membership, diagnostic, and treatment criteria based on automated review of electronic billing, claims, and pharmacy records. Diagnosis and treatment were confirmed by manual review of medical records. A telephone questionnaire was administered. A work related symptom score was assigned to each participant based on responses to questions about work related asthma symptoms, medication use, and symptom triggers. Blinded to participants' answers to these questions, two researchers independently reviewed the self-reported work histories and assigned exposure ratings. A final exposure score was then calculated. Participants with sufficient evidence for work related symptoms and exposure were classified as having WEA. RESULTS: Of the 598 participants with complete data, 557 (93%) were working, and 136 (23%) fulfilled the criteria for WEA. Those with WEA were more likely to be male and to report that they had been bothered by asthma symptoms during the past seven days. CONCLUSIONS: Workplace exacerbation of asthma was common in this study population, occurring in over a fifth of these adults with asthma. Physicians should consider that work can contribute to the exacerbation of symptoms when treating adults with asthma.
SN - 1351-0711
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health/CDC, Morgantown, WV 26501, USA. pkh0@cdc.gov
U2 - PMID: 16601014.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106273996&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Vernon, John A.
T1 - Letter From the Commissioner's Office at the US FDA.
JO - PharmacoEconomics
JF - PharmacoEconomics
Y1 - 2006/08//
VL - 24
IS - 12
M3 - Editorial
SP - 1179
EP - 1179
PB - Springer Science & Business Media B.V.
SN - 11707690
AB - To support decision making, many countries have now introduced some formal assessment process to evaluate whether health technologies represent good "value for money". These often take the form of decision models that can be used to explore elements of importance to generalisability of study results across clinical settings and jurisdictions. The objective of this review was to assess whether articles reporting decision-analytic models in the area of osteoporosis provided enough information to enable decision makers in different countries/jurisdictions to fully appreciate the variability of results according to location and be able to apply the evaluation to their own setting.Of the 18 articles included in the review, only three explicitly stated the decision-making audience. It was not possible to infer a decision-making audience in eight studies. The target population was well reported, as were resource and cost data, and clinical data used for estimates of relative risk reduction. However, baseline risk was rarely adapted to the relevant jurisdiction, and when no decision maker was explicit it was difficult to assess whether the reported cost and resource use data were in fact relevant. A few studies used sensitivity analysis to explore elements of generalisability, such as compliance rates and baseline fracture risk rates, although such analyses were generally restricted to evaluating parameter uncertainty.This review found that variability in cost effectiveness across locations is addressed to a varying extent in modelling studies in the field of osteoporosis, limiting their use for decision makers across different locations. Transparency of reporting is expected to increase as methodology develops and decision makers publish "reference case" type guidance. [ABSTRACT FROM AUTHOR]
AB - Copyright of PharmacoEconomics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LETTERS
KW - PUBLIC officers
KW - ECONOMIC policy
KW - PHARMACOGENOMICS
KW - UNITED States. Food & Drug Administration
KW - VERNON, John A.
N1 - Accession Number: 23276720; Vernon, John A. 1; Affiliation: 1: Senior Economic Policy Advisor, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, US; Source Info: 2006, Vol. 24 Issue 12, p1179; Subject Term: LETTERS; Subject Term: PUBLIC officers; Subject Term: ECONOMIC policy; Subject Term: PHARMACOGENOMICS; Company/Entity: UNITED States. Food & Drug Administration; People: VERNON, John A.; Number of Pages: 1p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collicott, Steven H.
AU - Lindsley, William G.
AU - Frazer, David G.
T1 - Zero-gravity liquid-vapor interfaces in circular cylinders.
JO - Physics of Fluids
JF - Physics of Fluids
Y1 - 2006/08//
VL - 18
IS - 8
M3 - Article
SP - 087109
PB - American Institute of Physics
SN - 10706631
AB - The zero-gravity problems of a liquid volume sealing a circular tube of gas and a gaseous volume in a circular tube of liquid both involve one phase obstructing another. The two problems differ only in contact angle. From pulmonary research there is a history of axisymmetric analyses for liquid droplets in circular tubes of gas. These analyses consider only axisymmetric solutions—an annulus and an axisymmetric plug. Only recently have nonsymmetric solutions for nonzero contact angle wetting liquids (0°–90° contact angle) been realized by the authors with the use of the Surface Evolver code. Similar to the problem of droplets in a gas filled tube, a bubble in a liquid-filled tube is of interest to the commercial satellite industry and in vascular physiology. Further analysis by the authors now fills in the other half of contact angle range, i.e., either a nonwetting liquid in a tube of gas (contact angles of 90°–180°), or equivalently, a gaseous bubble in a liquid that wets the tube wall. Conditions for the existence and stability of solutions of three topologies are examined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physics of Fluids is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRAVITY -- Physiological effect
KW - GAS-liquid interfaces
KW - CONTACT angle
KW - CYLINDERS (Engines)
KW - AXIAL flow
N1 - Accession Number: 22257055; Collicott, Steven H. 1; Email Address: collicot@purdue.edu Lindsley, William G. 2 Frazer, David G. 2; Affiliation: 1: School of Aeronautics and Astronautics, Purdue University, West Lafayette, Indiana 47907 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Source Info: Aug2006, Vol. 18 Issue 8, p087109; Subject Term: GRAVITY -- Physiological effect; Subject Term: GAS-liquid interfaces; Subject Term: CONTACT angle; Subject Term: CYLINDERS (Engines); Subject Term: AXIAL flow; NAICS/Industry Codes: 333995 Fluid Power Cylinder and Actuator Manufacturing; Number of Pages: 8p; Illustrations: 6 Diagrams, 10 Graphs; Document Type: Article
L3 - 10.1063/1.2345026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22257055&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atenstaedt, R. L.
T1 - Does danger lurk in the library?
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2006/08//
VL - 120
IS - 8
M3 - Article
SP - 776
EP - 777
SN - 00333506
AB - The article discusses the potential of library books in the transmission of diseases. In Great Britain, under the Public Health Act 1984, any registered medical practitioner attending a patient suffering from or who he suspects is suffering from a notifiable disease, is required to inform the proper officer of the district council in whose area the patient resides. Section 25 of the law prevents a person who knows that they are suffering from any communicable diseases from borrowing or using a book from any public or circulating library.
KW - COMMUNICABLE diseases -- Transmission
KW - BOOKS
KW - PUBLIC health
KW - PUBLIC health laws
KW - LIBRARIES
KW - GREAT Britain
KW - Books
KW - Disease transmission
KW - Notifiable Disease
KW - Public Health
N1 - Accession Number: 22352453; Atenstaedt, R. L. 1; Email Address: Robert.Atenstaedt@nphs.wales.nhs.uk; Affiliation: 1: National Public Health Service for Wales (NPHS) and Institute of Medical and Social Care Research (IMSCaR), Ardudwy, Normal Site, University of Wales, Bangor, Gwynedd LL57 2PX, UK; Source Info: Aug2006, Vol. 120 Issue 8, p776; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: BOOKS; Subject Term: PUBLIC health; Subject Term: PUBLIC health laws; Subject Term: LIBRARIES; Subject Term: GREAT Britain; Author-Supplied Keyword: Books; Author-Supplied Keyword: Disease transmission; Author-Supplied Keyword: Notifiable Disease; Author-Supplied Keyword: Public Health; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451211 Book Stores; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 519121 Libraries; NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.puhe.2006.03.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22352453&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104744654
T1 - Does danger lurk in the library?
AU - Atenstaedt, R L
Y1 - 2006/08//
N1 - Accession Number: 104744654. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 0376507.
KW - Books
KW - Disease Transmission
KW - Libraries
KW - Public Health -- Legislation and Jurisprudence
SP - 776
EP - 777
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 120
IS - 8
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service for Wales (NPHS) and Institute of Medical and Social Care Research (IMSCaR), Ardudwy, Normal Site, University of Wales, Bangor, Gwynedd LL57 2PX, UK. Robert.Atenstaedt@nphs.wales.nhs.uk
U2 - PMID: 16824561.
DO - 10.1016/j.puhe.2006.03.012
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kodell, R.L.
AU - Chen, J.J.
AU - Delongchamp, R.R.
AU - Young, J.F.
T1 - Hierarchical models for probabilistic dose–response assessment
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2006/08//
VL - 45
IS - 3
M3 - Article
SP - 265
EP - 272
SN - 02732300
AB - Abstract: Probabilistic risk assessment is gaining acceptance as the most appropriate way to characterize and communicate uncertainties in estimates of human health risk and/or reference levels of exposure such as benchmark doses. Although probabilistic techniques are well established in the exposure-assessment component of the National Research Council’s risk-assessment paradigm, they are less well developed in the dose–response-assessment component. This paper proposes the use of hierarchical statistical models as tools for implementing probabilistic dose–response assessments, in that such models provide a natural connection between the pharmacokinetic (PK) and pharmacodynamic (PD) components of dose–response models. The results show that incorporating internal dose information into dose–response assessments via the coupling of PK and PD models in a hierarchical structure can reduce the uncertainty in the dose–response assessment of risk. However, information on the mean of the internal dose distribution is sufficient; having information on the variance of internal dose does not affect the uncertainty in the resulting estimates of excess risks or benchmark doses. In addition, the complexity of a PK model of internal dose does not affect how the variability in risk is measured via the ultimate endpoint. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Bayesian analysis
KW - Investment analysis
KW - Benchmarking (Management)
KW - Bayesian
KW - Benchmark dose
KW - Binomial
KW - Internal dose
KW - Michaelis–Menten
KW - Monte Carlo
KW - PBPK
KW - PK/PD
KW - Risk management
KW - Two-stage model
KW - Uncertainty
KW - Weibull
N1 - Accession Number: 21683370; Kodell, R.L.; Email Address: rkodell@nctr.fda.gov; Chen, J.J. 1; Delongchamp, R.R. 1; Young, J.F. 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, 3900 NCTR Road, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Aug2006, Vol. 45 Issue 3, p265; Thesaurus Term: Risk assessment; Subject Term: Bayesian analysis; Subject Term: Investment analysis; Subject Term: Benchmarking (Management); Author-Supplied Keyword: Bayesian; Author-Supplied Keyword: Benchmark dose; Author-Supplied Keyword: Binomial; Author-Supplied Keyword: Internal dose; Author-Supplied Keyword: Michaelis–Menten; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: PBPK; Author-Supplied Keyword: PK/PD; Author-Supplied Keyword: Risk management; Author-Supplied Keyword: Two-stage model; Author-Supplied Keyword: Uncertainty; Author-Supplied Keyword: Weibull; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.05.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21683370&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoebe, Christian J. P. A.
AU - Rademaker, Christiaan W.
AU - Brouwers, Elfi F. H. G.
AU - Ter Waarbeek, Henriërte L. G.
AU - Van Bergen, Jan E. A. M.
T1 - Acceptability of Self-Taken Vaginal Swabs and First-Catch Urine Samples for the Diagnosis of Urogenital Chlamydia trachomatis and Neisseria gonorrhoeae With an Amplified DNA Assay in Young Women Attending a Public Health Sexually Transmitted Disease Clinic
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2006/08//
VL - 33
IS - 8
M3 - Article
SP - 491
EP - 495
SN - 01485717
AB - The article assesses the acceptability and feasibility of 2 noninvasive diagnostic approaches for Chlamydia trachomatis and Neisseria gonorrhoeae. Participants of the study were 413 young women who underwent STD testing by self-taken vaginal swab (SVS) and a first-catch urine (FCU) sample by nucleic acid amplification test. The research indicated that SVS combined with FCU can be an important enhancing tool in public health approaches.
KW - MEDICAL screening
KW - CHLAMYDIA trachomatis
KW - NEISSERIA gonorrhoeae
KW - SEXUALLY transmitted diseases
KW - COMMUNICABLE diseases
KW - WOMEN -- Health
N1 - Accession Number: 21861114; Hoebe, Christian J. P. A. 1,2; Email Address: hoebec@ggdozl.nl Rademaker, Christiaan W. 1 Brouwers, Elfi F. H. G. 1 Ter Waarbeek, Henriërte L. G. 1 Van Bergen, Jan E. A. M. 3; Affiliation: 1: Department of Infectious Diseases, South Limburg Public Health Service, Heerlen, Netherlands 2: Maastricht Infection Center, University Hospital Maastricht, Maastricht, Netherlands 3: STI AIDS Netherlands, Amsterdam, Netherlands; Source Info: Aug2006, Vol. 33 Issue 8, p491; Subject Term: MEDICAL screening; Subject Term: CHLAMYDIA trachomatis; Subject Term: NEISSERIA gonorrhoeae; Subject Term: SEXUALLY transmitted diseases; Subject Term: COMMUNICABLE diseases; Subject Term: WOMEN -- Health; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1097/01.olq.0000204619.87066.28
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21861114&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106212997
T1 - Acceptability of self-taken vaginal swabs and first-catch urine samples for the diagnosis of urogenital chlamydia trachomatis and Neisseria gonorrhoeae with an amplified DNA assay in young women attending a public health sexually transmitted disease clinic.
AU - Hoebe CJP
AU - Rademaker CW
AU - Brouwers EEH
AU - Ter Waarbeek HLG
AU - van Bergen JEA
Y1 - 2006/08//
N1 - Accession Number: 106212997. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7705941.
KW - Chlamydia Infections -- Diagnosis
KW - Gonorrhea -- Diagnosis
KW - Patient Attitudes
KW - Self Care
KW - Sexually Transmitted Diseases, Bacterial -- Diagnosis
KW - Adolescence
KW - Adult
KW - Ambulatory Care Facilities
KW - Cervical Smears
KW - Chlamydia Infections -- Microbiology
KW - Chlamydia Infections -- Prevention and Control
KW - Chlamydia Infections -- Urine
KW - Chlamydia Trachomatis
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - DNA -- Analysis
KW - Female
KW - Fisher's Exact Test
KW - Gonorrhea -- Microbiology
KW - Gonorrhea -- Prevention and Control
KW - Gonorrhea -- Urine
KW - Multivariate Analysis
KW - Neisseria
KW - Netherlands
KW - Nucleic Acid Amplification Techniques
KW - Prospective Studies
KW - Questionnaires
KW - Sexually Transmitted Diseases, Bacterial -- Microbiology
KW - Sexually Transmitted Diseases, Bacterial -- Prevention and Control
KW - Sexually Transmitted Diseases, Bacterial -- Urine
KW - Urinalysis
KW - Human
SP - 491
EP - 495
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 33
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Department of Infectious Diseases, South Limburg Public Health Service, PO Box 155, NL-6400 AD Heerlen, The Netherlands; hoebec@ggdozl.nl
U2 - PMID: 16547452.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106212997&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106156972
T1 - Population-based trends in volumes and rates of ambulatory lumbar spine surgery.
AU - Gray DT
AU - Deyo RA
AU - Kreuter W
AU - Mirza SK
AU - Heagerty PJ
AU - Comstock BA
AU - Chan L
Y1 - 2006/08//
N1 - Accession Number: 106156972. Language: English. Entry Date: 20070921. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Commentary: Katz JN. Point of view. (SPINE) Aug2006; 31 (17): 1964-1964. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Grant Information: Grant No. P60 AR 48093 from the National Institute for Arthritis, Musculoskeletal and Skin Diseases. NLM UID: 7610646.
KW - Ambulatory Surgery -- Trends
KW - Lumbar Vertebrae -- Surgery
KW - Orthopedic Surgery -- Trends
KW - Adult
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Diskectomy -- Trends
KW - Funding Source
KW - Laminectomy -- Trends
KW - Mathematics
KW - Spinal Fusion -- Trends
KW - United States
KW - Human
SP - 1957
EP - 1963
JO - Spine (03622436)
JF - Spine (03622436)
JA - SPINE
VL - 31
IS - 17
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - STUDY DESIGN: Sequential cross-sectional study. OBJECTIVES: To quantify patterns of outpatient lumbar spine surgery. SUMMARY OF BACKGROUND DATA: Outpatient lumbar spine surgery patterns are undocumented. METHODS: We used CPT-4 and ICD-9-CM diagnosis/procedure codes to identify lumbar spine operations in 20+ year olds. We combined sample volume estimates from the National Hospital Discharge Survey (NHDS), the National Survey of Ambulatory Surgery (NSAS), and the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) with complete case counts from HCUP's State Inpatient Databases (SIDs) and State Ambulatory Surgery Databases (SASDs) for four geographically diverse states. We excluded pregnant patients and those with vertebral fractures, cancer, trauma, or infection. We calculated age- and sex-adjusted rates. RESULTS: Ambulatory cases comprised 4% to 13% of procedures performed from 1994 to 1996 (NHDS/NSAS data), versus 9% to 17% for 1997 to 2000 (SID/SASD data). Discectomies comprised 70% to 90% of outpatient cases. Conversely, proportions of discectomies performed on outpatients rose from 4% in 1994 to 26% in 2000. Outpatient fusions and laminectomies were uncommon. NIS data indicate that nationwide inpatient surgery rates were stable (159 cases/100,000 in 1994 vs. 162/100,000 in 2000). However, combined data from all sources suggest that inpatient and outpatient rates rose from 164 cases/100,000 in 1994 to 201/100,000 in 2000. CONCLUSIONS: While inpatient lumbar surgery rates remained relatively stable for 1994 to 2000, outpatient surgery increased over time.
SN - 0362-2436
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, 540 Gaither Road Room 3353, Rockville, MD 20850; darryl.gray@ahrq.hhs.gov
U2 - PMID: 16924213.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106156972&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Saber M. Hussain
AU - Amanda K. Javorina
AU - Amanda M. Schrand
AU - Helen M. Duhart
AU - Syed F. Ali
AU - John J. Schlager
T1 - The Interaction of Manganese Nanoparticles with PC-12 Cells Induces Dopamine Depletion.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/08//
VL - 92
IS - 2
M3 - Article
SP - 456
EP - 463
PB - Oxford University Press / USA
SN - 10966080
AB - This investigation was designed to determine whether nano-sized manganese oxide (Mn-40nm) particles would induce dopamine (DA) depletion in a cultured neuronal phenotype, PC-12 cells, similar to free ionic manganese (Mn2+). Cells were exposed to Mn-40nm, Mn2+ (acetate), or known cytotoxic silver nanoparticles (Ag-15nm) for 24 h. Phase-contrast microscopy studies show that Mn-40nm or Mn2+ exposure did not greatly change morphology of PC-12 cells. However, Ag-15nm and AgNO3 produce cell shrinkage and irregular membrane borders compared to control cells. Further microscopic studies at higher resolution demonstrated that Mn-40nm nanoparticles and agglomerates were effectively internalized by PC-12 cells. Mitochondrial reduction activity, a sensitive measure of particle and metal cytotoxicity, showed only moderate toxicity for Mn-40nm compared to similar Ag-15nm and Mn2+ doses. Mn-40nm and Mn2+ dose dependently depleted DA and its metabolites, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), while Ag-15nm only significantly reduced DA and DOPAC at concentrations of 50 μg/ml. Therefore, the DA depletion of Mn-40nm was most similar to Mn2+, which is known to induce concentration-dependent DA depletion. There was a significant increase (> 10-fold) in reactive oxygen species (ROS) with Mn-40nm exposure, suggesting that increased ROS levels may participate in DA depletion. These results clearly demonstrate that nanoscale manganese can deplete DA, DOPAC, and HVA in a dose-dependent manner. Further study is required to evaluate the specific intracellular distribution of Mn-40nm nanoparticles, metal dissolution rates in cells and cellular matrices, if DA depletion is induced in vivo, and the propensity of Mn nanoparticles to cross the blood-brain barrier or be selectively uptaken by nasal epithelium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Photosynthetic oxygen evolution
KW - Active oxygen
KW - Cerebrospinal fluid
KW - Nanoparticles
N1 - Accession Number: 21756849; Saber M. Hussain 1; Amanda K. Javorina 1; Amanda M. Schrand 2; Helen M. Duhart 3; Syed F. Ali 3; John J. Schlager 1; Affiliations: 1: Applied Biotechnology Branch, Human Effectiveness Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Ohio 45431;; 2: Department of Chemical and Materials Engineering, University of Dayton, Dayton, Ohio 45469; and; 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079; Issue Info: Aug2006, Vol. 92 Issue 2, p456; Thesaurus Term: Photosynthetic oxygen evolution; Subject Term: Active oxygen; Subject Term: Cerebrospinal fluid; Subject Term: Nanoparticles; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Khan, Arifa S.
AU - Kumar, Dhanya
T1 - Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humans.
JO - Transfusion
JF - Transfusion
Y1 - 2006/08//
VL - 46
IS - 8
M3 - Article
SP - 1352
EP - 1359
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Cross-species infection of humans with simian foamy virus (SFV) has been reported in European and North American nonhuman primate (NHP) handlers, primarily due to wound injuries involving infected animals in research centers and zoos. Additionally, African hunters have been found to be infected with SFV by exposure to body fluids, blood, or tissues of infected NHPs in the wild. The persistence of infectious virus in peripheral blood mononuclear cells (PBMNC) and the recent identification of some infected blood donors has raised safety concerns regarding potential virus transmission by blood transfusion. STUDY DESIGN AND METHODS: SFV infection by blood transfusion was evaluated by whole-blood transfer from two naturally-infected rhesus macaques (designated as D1 and D2) to retrovirus-free monkeys. Blood from D1 was transfused to two recipient monkeys R1 and R2 and from D2 to monkeys R3 and R4. Virus transmission was evaluated by immunoassays, polymerase chain reaction assays, and coculture of PBMNC for SFV isolation. RESULTS: SFV infection was seen in R1 and R2 based on development of virus-specific antibodies, identification of SFV sequences in monkey PBMNC, and isolation of infectious virus from PBMNC. Furthermore, both R1 and R2 remained SFV-positive at about 1 year after transfusion, which was the last time tested. No evidence of SFV infection was seen in R3 and R4. CONCLUSION: SFV transmission in macaques occurred by transfusion of blood from one of two infected donor animals. These results indicate the potential of SFV transfusion transmission in humans, which may depend on virus-specific or donor-related factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SIMIAN viruses
KW - RHESUS monkey
KW - BLOOD donors
KW - BLOOD transfusion
KW - VIRAL transmission
KW - TRANSMISSION
N1 - Accession Number: 21679045; Khan, Arifa S. 1; Email Address: arifa.khan@fda.hhs.gov Kumar, Dhanya 1; Affiliation: 1: From the Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland; Source Info: Aug2006, Vol. 46 Issue 8, p1352; Subject Term: SIMIAN viruses; Subject Term: RHESUS monkey; Subject Term: BLOOD donors; Subject Term: BLOOD transfusion; Subject Term: VIRAL transmission; Subject Term: TRANSMISSION; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1537-2995.2006.00862.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21679045&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105849566
T1 - Simian foamy virus infection by whole-blood transfer in rhesus macaques: potential for transfusion transmission in humans.
AU - Khan AS
AU - Kumar D
Y1 - 2006/08//
N1 - Accession Number: 105849566. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Blood Transfusion -- Adverse Effects
KW - Retrovirus Infections -- Transmission
KW - Retroviruses -- Immunology
KW - Retroviruses
KW - Zoonoses -- Transmission
KW - Animals -- Blood
KW - Animals
KW - Antibodies, Viral -- Blood
KW - Antibodies, Viral -- Immunology
KW - Cells
KW - Leukocytes, Mononuclear -- Immunology
KW - Leukocytes, Mononuclear
KW - Models, Biological
KW - Occupational Exposure
KW - Primates
KW - Retrovirus Infections -- Blood
KW - Retrovirus Infections -- Immunology
KW - RNA -- Blood
KW - Tissue Culture Techniques
KW - Zoonoses
SP - 1352
EP - 1359
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 46
IS - 8
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND: Cross-species infection of humans with simian foamy virus (SFV) has been reported in European and North American nonhuman primate (NHP) handlers, primarily due to wound injuries involving infected animals in research centers and zoos. Additionally, African hunters have been found to be infected with SFV by exposure to body fluids, blood, or tissues of infected NHPs in the wild. The persistence of infectious virus in peripheral blood mononuclear cells (PBMNC) and the recent identification of some infected blood donors has raised safety concerns regarding potential virus transmission by blood transfusion. STUDY DESIGN AND METHODS: SFV infection by blood transfusion was evaluated by whole-blood transfer from two naturally-infected rhesus macaques (designated as D1 and D2) to retrovirus-free monkeys. Blood from D1 was transfused to two recipient monkeys R1 and R2 and from D2 to monkeys R3 and R4. Virus transmission was evaluated by immunoassays, polymerase chain reaction assays, and coculture of PBMNC for SFV isolation. RESULTS: SFV infection was seen in R1 and R2 based on development of virus-specific antibodies, identification of SFV sequences in monkey PBMNC, and isolation of infectious virus from PBMNC. Furthermore, both R1 and R2 remained SFV-positive at about 1 year after transfusion, which was the last time tested. No evidence of SFV infection was seen in R3 and R4. CONCLUSION: SFV transmission in macaques occurred by transfusion of blood from one of two infected donor animals. These results indicate the potential of SFV transfusion transmission in humans, which may depend on virus-specific or donor-related factors.
SN - 0041-1132
AD - Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA. arifa.khan@fda.hhs.gov
U2 - PMID: 16934071.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105849566&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-11677-003
AN - 2006-11677-003
AU - Lathers, Claire M.
AU - Schraeder, Paul L.
T1 - Stress and sudden death.
JF - Epilepsy & Behavior
JO - Epilepsy & Behavior
JA - Epilepsy Behav
Y1 - 2006/08//
VL - 9
IS - 2
SP - 236
EP - 242
CY - Netherlands
PB - Elsevier Science
SN - 1525-5050
AD - Lathers, Claire M., 115 South Manning Boulevard, Albany, NY, US, 12203
N1 - Accession Number: 2006-11677-003. PMID: 16872908 Partial author list: First Author & Affiliation: Lathers, Claire M.; Office of the Director, Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20060925. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Epilepsy; Heart Disorders; Mental Disorders; Stress. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2006.
AB - Cardiac patients, psychiatric patients, and certain ethnic groups experiencing acute stressful circumstances are at risk for unexpected sudden death. Although stress is associated with changes in autonomic neural function, its role as a potential risk factor for sudden unexpected death in epilepsy (SUDEP) is not known. The association of epilepsy with cardiac abnormalities, such as neurogenic arrhythmias and microscopic perivascular and interstitial fibrosis, and with depression and anxiety indicates that emotional stress should be evaluated as a potential risk factor for SUDEP. The impact of adverse emotional states on the autonomic control of cardiac rhythm is a known important factor leading to cardiac dysrhythmias in humans and other species. The interaction between emotional factors and the arrythmogenic potential of epileptiform discharges and the possibility of benefit from stress management intervention need to be investigated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - stress
KW - sudden death
KW - epilepsy
KW - cardiac abnormalities
KW - 2006
KW - Death and Dying
KW - Epilepsy
KW - Heart Disorders
KW - Mental Disorders
KW - Stress
KW - 2006
DO - 10.1016/j.yebeh.2006.06.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11677-003&site=ehost-live&scope=site
UR - lathers@attglobal.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23111-035
AN - 2006-23111-035
AU - Bellamy, Nikki
AU - Matthew, Resa F.
AU - Wang, Min Qi
T1 - Factor Analysis to Examine Psychometric Properties of Family Functioning Measures.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 2006/08//
VL - 99
IS - 1
SP - 267
EP - 273
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
AD - Bellamy, Nikki, SAMHSA, CSAP, DKASI, 1 Choke Cherry Road, Room 4-1005, Rockville, MD, US, 20857
N1 - Accession Number: 2006-23111-035. PMID: 17037479 Partial author list: First Author & Affiliation: Bellamy, Nikki; Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, MD, US. Other Publishers: Sage Publications. Release Date: 20070212. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Behavior Problems; Drug Abuse; Family; Psychometrics. Minor Descriptor: Factor Analysis; Test Reliability. Classification: Tests & Testing (2220); Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Family Environment Scale-Form R-Conflict Subscale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2006.
AB - To assess the relationship of family functioning to problem behaviors and alcohol and drug use among youth, researchers must test the effects of interventions using suitably constructed and psychometrically sound scales. This study evaluated whether originally calculated coefficients alpha underestimate the reliability of the family functioning measures given. Through exploratory factor analysis, estimates of alternative internal consistency reliability which might improve the estimate of reliability were examined. Responses of 755 adults from Strengthening Multi-ethnic Families and Communities were analyzed. Coefficients alpha for two scales were modest (α = .68 and α = .75), and factor analysis indicated that the scales were multidimensional. After exploratory factor analysis, the reassessment of reliability based on the extracted factors indicated an overall increase in the coefficients alpha. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Family Functioning Measures
KW - psychometric properties
KW - alcohol and drug use
KW - behavior problems
KW - factor analysis
KW - test reliability
KW - 2006
KW - Alcohol Abuse
KW - Behavior Problems
KW - Drug Abuse
KW - Family
KW - Psychometrics
KW - Factor Analysis
KW - Test Reliability
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention, US. Grant: UDI SP09227. Recipients: No recipient indicated
DO - 10.2466/PR0.99.5.267-273
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23111-035&site=ehost-live&scope=site
UR - nikki.bellamy@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-11510-002
AN - 2006-11510-002
AU - House, Laura E.
AU - Stiffman, Arlene R.
AU - Brown, Eddie
T1 - Unraveling Cultural Threads: A Qualitative Study of Culture and Ethnic Identity Among Urban Southwestern American Indian Youth Parents and Elders.
JF - Journal of Child and Family Studies
JO - Journal of Child and Family Studies
JA - J Child Fam Stud
Y1 - 2006/08//
VL - 15
IS - 4
SP - 393
EP - 407
CY - Germany
PB - Springer
SN - 1062-1024
SN - 1573-2843
AD - House, Laura E., Substance Abuse and Mental Health Services Administration, Health and Human Services, Organization and Finance Branch, 13702 Colgate Way, # 1033, Silver Spring, MD, US, 20705
N1 - Accession Number: 2006-11510-002. Partial author list: First Author & Affiliation: House, Laura E.; Substance Abuse and Mental Health Services Administration, Health and Human Services, Silver Spring, MD, US. Release Date: 20061023. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Ethnic Identity; Urban Environments. Minor Descriptor: Parents. Classification: Culture & Ethnology (2930). Population: Human (10). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Aug, 2006.
AB - We utilized qualitative methods to explore ethnic and cultural identity among urban Southwestern American Indian youth, parents, and elders. Twenty-four respondents ranging in age from approximately 13 to 90 years were interviewed in focus groups divided by age. Six major themes and seventeen sub-themes related to tribal and pan-American Indian ethnic identity were identified. Two important findings emerging from our study were that common ethnic identity constructs can be validated and new identity constructs discovered through qualitative methods. These and other findings suggest the importance of qualitative methods in better understanding cultural and ethnic identity. Of particular significance was the notion that the most salient and relevant identity constructs can be learned from the voices and perspectives of ethnic identity members themselves across generations, age, tribal groups, gender, and reservation and urban residence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnic identity
KW - cultural identity
KW - parents
KW - elders
KW - Southwestern American Indian youth
KW - urban environment
KW - 2006
KW - American Indians
KW - Ethnic Identity
KW - Urban Environments
KW - Parents
KW - 2006
U1 - Sponsor: National Institute of Mental Health. Grant: K02 MH01797-01A1. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse. Grant: R24DA13572-0; R01 DA 13227-01. Recipients: No recipient indicated
DO - 10.1007/s10826-006-9038-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11510-002&site=ehost-live&scope=site
UR - laura.house@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-08181-006
AN - 2006-08181-006
AU - Griffith, Derek M.
AU - Moy, Ernest
AU - Reischl, Thomas M.
AU - Dayton, Elizabeth
T1 - National Data for Monitoring and Evaluating Racial and Ethnic Health Inequities: Where Do We Go From Here?
T3 - Health disparities
JF - Health Education & Behavior
JO - Health Education & Behavior
JA - Health Educ Behav
Y1 - 2006/08//
VL - 33
IS - 4
SP - 470
EP - 487
CY - US
PB - Sage Publications
SN - 1090-1981
SN - 1552-6127
AD - Griffith, Derek M., Department of Health Behavior & Health Education, School of Public Health, University of Michigan, 109 South Observatory Street, M2525 SPH II, Ann Arbor, MI, US, 48109-2029
N1 - Accession Number: 2006-08181-006. PMID: 16769756 Other Journal Title: Health Education Monographs; Health Education Quarterly. Partial author list: First Author & Affiliation: Griffith, Derek M.; Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, US. Release Date: 20060731. Correction Date: 20110725. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Education; Racial and Ethnic Differences. Minor Descriptor: Terminology. Classification: Social Structure & Organization (2910); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 18. Issue Publication Date: Aug, 2006.
AB - The elimination of racial and ethnic health inequities has become a central focus of health education and the national health agenda. The documentation of an increasing gap in life expectancy and other health outcomes suggests the need for more effective strategies to eliminate health inequities, which can be informed by better monitoring and evaluation data. Although the sophistication and volume of health data available have increased dramatically in recent years, this article examines the quality of the current data collected to achieve the goal of eliminating racial and ethnic health inequities. This article explores several key aspects of data to inform addressing inequities including terminology, the role of data, and explanations of the problem. The authors conclude with recommendations for refining data collection to facilitate the elimination of racial and ethnic health inequities and suggest how the Society for Public Health Education can become a more central figure in our national efforts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial and ethnic differences
KW - health inequalities
KW - health education
KW - terminology
KW - 2006
KW - Health
KW - Health Education
KW - Racial and Ethnic Differences
KW - Terminology
KW - 2006
DO - 10.1177/1090198106287923
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08181-006&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-0018-9176
UR - derekmg@umich.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10067-001
AN - 2006-10067-001
AU - Encinosa, William E.
AU - Bernard, Didem M.
AU - Chen, Chi-Chang
AU - Steiner, Claudia A.
T1 - Healthcare Utilization and Outcomes After Bariatric Surgery.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2006/08//
VL - 44
IS - 8
SP - 706
EP - 712
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Encinosa, William E., Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Room 5105, Rockville, MD, US, 20850
N1 - Accession Number: 2006-10067-001. PMID: 16862031 Partial author list: First Author & Affiliation: Encinosa, William E.; Center for Delivery, Organization, and Markets, Rockville, MD, US. Release Date: 20070212. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Surgery; Treatment Outcomes; Bariatric Surgery. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2006.
AB - Objective: Bariatric surgery is one of the fastest growing hospital procedures. Our objective is to examine the safety outcomes and utilization of resources in the 6 months after bariatric surgery using a nationwide, population-based sample. Data/Design: We examine insurance claims for 2522 bariatric surgeries, at 308 hospitals, among a population of 5.6 million nonelderly people covered by large employers in the 2001-2002 MarketScan data. Outcomes and costs were risk-adjusted using multivariate regression methods. Principal Findings: Although the complication rate was 21.9% during the initial surgical stay, the rate increased by 81% (P<0.01) to 39.6% (95% confidence interval, 37.7-41.5%) over the 180 days after discharge. A total of 10.8% of the patients without 30-day complications developed a complication between 30 days and 180 days. Overall, 18.2% of the patients had some type of postoperative visit to the hospital with a complication (through readmission, outpatient hospital visit, or emergency room visit) within 180 days. Although there was no difference between men and women, the near-elderly had a 26% (P<0.01) higher risk-adjusted complication rate than those age 18 to 39 years. Total 6-month risk-adjusted healthcare payments were $65,031 for those with 180-day readmissions compared with $27,125 for those without readmissions (P<0.01). Conclusion: In contrast to current bariatric studies, which report a 20% in-hospital complication rate, we find a significantly higher complication rate over the 6 months after surgery, resulting in costly readmissions and emergency room visits. Thus, a clear way to reduce the costs and improve outcomes of bariatric surgery is to address the high rate of postoperative complications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care utilization
KW - treatment outcomes
KW - bariatric surgery
KW - hospital procedures
KW - 2006
KW - Health Care Utilization
KW - Surgery
KW - Treatment Outcomes
KW - Bariatric Surgery
KW - 2006
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1097/01.mlr.0000220833.89050.ed
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10067-001&site=ehost-live&scope=site
UR - wencinos@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10443-026
AN - 2006-10443-026
AU - del Vecchio, Paolo
T1 - 'Evolution of the Antipsychiatry Movement Into Mental Health Consumerism': Comment.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/08//
VL - 57
IS - 8
SP - 1212
EP - 1213
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2006-10443-026. PMID: 16870978 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: del Vecchio, Paolo; Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration, US. Release Date: 20060905. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Psychiatry; Social Movements. Minor Descriptor: Consumerism. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Aug, 2006.
AB - Comments on an article, 'Evolution of the Antipsychiatry Movement Into Mental Health Consumerism,' by David J. Rissmiller and Joshua H. Rissmiller (see record [rid]2006-07909-015[/rid]). The current author states that the article linking antipsychiatry with the mental health consumer movement does a disservice to the thousands of consumers working to improve the lives of people with mental illnesses. The essay also fails to acknowledge the many psychiatrists who partner with them. Rather than 'fighting against pharmacological treatment,' the movement supports the consumers choice of treatments--including medications--and is often active in promoting increased financing for mental health services, insurance parity, and the protection of individual rights, such as health care privacy. It is unjust to discredit mental health care consumer advocates and their hard work by linking them with antipsychiatrists, including Scientologists. Psychiatry recognizes that alliances with those served--whether on the clinical, community, or policy levels--are in our mutual interest: the promotion of mental health recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antipsychiatry movement
KW - mental health consumerism
KW - 2006
KW - Psychiatry
KW - Social Movements
KW - Consumerism
KW - 2006
DO - 10.1176/appi.ps.57.8.1212-a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10443-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10339-007
AN - 2006-10339-007
AU - Hellinger, Fred J.
AU - Encinosa, William E.
T1 - The Impact of State Laws Limiting Malpractice Damage Awards on Health Care Expenditures.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/08//
VL - 96
IS - 8
SP - 1375
EP - 1381
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Hellinger, Fred J., Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Room 5319, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2006-10339-007. PMID: 16809580 Partial author list: First Author & Affiliation: Hellinger, Fred J.; Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20070305. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Laws; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2006.
AB - Twenty-eight states have laws that limit payments in malpractice cases, and several studies indicate that these laws reduce the frequency and severity of malpractice claims and lower premiums. Moreover, proponents believe that such laws reduce health care expenditures by reducing the practice of defensive medicine. However, there is a dearth of empirical evidence about the impact of these laws on the cost of health care. We used multivariate models and relatively recent data to estimate the impact of state tort reform laws that directly limit malpractice damage payments on health care expenditures. Estimates from these models suggest that laws limiting malpractice payments lower state health care expenditures by between 3% and 4%. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state laws impact
KW - malpractice damage payments
KW - health care expenditures
KW - 2006
KW - Health Care Costs
KW - Laws
KW - Health Care Policy
KW - 2006
DO - 10.2105/AJPH.2005.077883
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10339-007&site=ehost-live&scope=site
UR - fhelling@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10339-018
AN - 2006-10339-018
AU - Yu, Stella M.
AU - Huang, Z. Jennifer
AU - Schwalberg, Renee H.
AU - Nyman, Rebecca M.
T1 - Parental English Proficiency and Children's Health Services Access.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/08//
VL - 96
IS - 8
SP - 1449
EP - 1455
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Yu, Stella M., Maternal and Child Health Bureau, 5600 Fishers Lane, 18A-55, Rockville, MD, US, 20857
N1 - Accession Number: 2006-10339-018. PMID: 16809589 Partial author list: First Author & Affiliation: Yu, Stella M.; Maternal and Child Health Bureau, Rockville, MD, US. Release Date: 20070305. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Huang, Z. Jennifer. Major Descriptor: Health Care Services; Language Proficiency; Parental Characteristics. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Tests & Measures: California Health Interview Survey. Methodology: Empirical Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2006.
AB - Objectives: We examined the relation between parents' level of English proficiency and their children's access to health care. Methods: Using the 2001 California Health Interview Survey, we conducted bivariate and multivariate analyses of several measures of children's access to health care (current health insurance status, usual source of care, emergency room visits, delayed or forgone care, traveling to another country for health care, and perceived discrimination in health care) and their association with parents' English proficiency. Results: Compared with English-speaking households, children in non-English-speaking households were more likely to lack health insurance, to not have doctor contact, and to go to other countries for health care and were less likely to use emergency rooms. Their parents were less likely to report their children's experiencing delayed or forgone care or discrimination in health care. Conclusion: English proficiency is a strong predictor of access to health insurance for children, and children in non-English-speaking families are especially likely to rely on other countries for their health care. English proficiency may mitigate the effects of race/ethnicity commonly observed in health care access and utilization studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental English proficiency
KW - childrens health services access
KW - 2006
KW - Health Care Services
KW - Language Proficiency
KW - Parental Characteristics
KW - 2006
U1 - Sponsor: Maternal and Child Health Bureau, Office of Data and Program Development, US. Other Details: Intergovernmental Personnel Act Agreement funding. Recipients: Huang, Z. Jennifer
DO - 10.2105/AJPH.2005.069500
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10339-018&site=ehost-live&scope=site
UR - syu@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09809-001
AN - 2006-09809-001
AU - Henriksen, Kerm
AU - Dayton, Elizabeth
T1 - Organizational Silence and Hidden Threats to Patient Safety.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2006/08//
VL - 41
IS - 4, part2
SP - 1539
EP - 1554
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Henriksen, Kerm, Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-09809-001. PMID: 16898978 Partial author list: First Author & Affiliation: Henriksen, Kerm; Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070205. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Organizational Behavior; Organizations; Patients; Safety. Minor Descriptor: Threat; Patient Safety. Classification: Organizational Behavior (3660). Population: Human (10). References Available: Y. Page Count: 16. Issue Publication Date: Aug, 2006.
AB - Organizational silence refers to a collective-level phenomenon of saying or doing very little in response to significant problems that face an organization. The paper focuses on some of the less obvious factors contributing to organizational silence that can serve as threats to patient safety. Converging areas of research from the cognitive, social, and organizational sciences and the study of sociotechnical systems help to identify some of the underlying factors that serve to shape and sustain organizational silence. These factors have been organized under three levels of analysis: (1) individual factors, including the availability heuristic, self-serving bias, and the status quo trap; (2) social factors, including conformity, diffusion of responsibility, and microclimates of distrust; and (3) organizational factors, including unchallenged beliefs, the good provider fallacy, and neglect of the interdependencies. Finally, a new role for health care leaders and managers is envisioned. It is one that places high value on understanding system complexity and does not take comfort in organizational silence. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - organizational silence
KW - patient safety
KW - hidden threats
KW - organizations reliability
KW - 2006
KW - Health Care Services
KW - Organizational Behavior
KW - Organizations
KW - Patients
KW - Safety
KW - Threat
KW - Patient Safety
KW - 2006
DO - 10.1111/j.1475-6773.2006.00564.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09809-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09809-002
AN - 2006-09809-002
AU - Battles, James B.
AU - Dixon, Nancy M.
AU - Borotkanics, Robert J.
AU - Rabin-Fastmen, Barbara
AU - Kaplan, Harold S.
T1 - Sensemaking of Patient Safety Risks and Hazards.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2006/08//
VL - 41
IS - 4, part2
SP - 1555
EP - 1575
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Battles, James B., United States Department of Health and Human Services, Agency for Healthcare Quality and Research, Center for Quality Improvement and Patient Safety, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-09809-002. PMID: 16898979 Partial author list: First Author & Affiliation: Battles, James B.; United States Department of Health and Human Services, Agency for Healthcare Quality and Research, Center for Quality Improvement and Patient Safety, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070205. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hazards; Organizational Learning; Patients; Safety; Risk Assessment. Minor Descriptor: Patient Safety. Classification: Organizational Behavior (3660); Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 21. Issue Publication Date: Aug, 2006.
AB - In order for organizations to become learning organizations, they must make sense of their environment and learn from safety events. Sensemaking, as described by Weick (1995), literally means making sense of events. The ultimate goal of sensemaking is to build the understanding that can inform and direct actions to eliminate risk and hazards that are a threat to patient safety. True sensemaking in patient safety must use both retrospective and prospective approach to learning. Sensemaking is as an essential part of the design process leading to risk informed design. Sensemaking serves as a conceptual framework to bring together well established approaches to assessment of risk and hazards: (1) at the single event level using root cause analysis (RCA), (2) at the processes level using failure modes effects analysis (FMEA) and (3) at the system level using probabilistic risk assessment (PRA). The results of these separate or combined approaches are most effective when end users in conversation-based meetings add their expertise and knowledge to the data produced by the RCA, FMEA, and/or PRA in order to make sense of the risks and hazards. Without ownership engendered by such conversations, the possibility of effective action to eliminate or minimize them is greatly reduced. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient safety
KW - risk factors
KW - hazards
KW - organizations learning
KW - sensemaking
KW - 2006
KW - Hazards
KW - Organizational Learning
KW - Patients
KW - Safety
KW - Risk Assessment
KW - Patient Safety
KW - 2006
DO - 10.1111/j.1475-6773.2006.00565.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09809-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-09809-006
AN - 2006-09809-006
AU - Tamuz, Michal
AU - Harrison, Michael I.
T1 - Improving Patient Safety in Hospitals: Contributions of High-Reliability Theory and Normal Accident Theory.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2006/08//
VL - 41
IS - 4, part2
SP - 1654
EP - 1676
CY - United Kingdom
PB - Blackwell Publishing
SN - 0017-9124
SN - 1475-6773
AD - Tamuz, Michal, Department of Preventive Medicine, University of Tennessee Health Science Center, 66 North Pauline, Suite 463, Memphis, TN, US, 38163
N1 - Accession Number: 2006-09809-006. PMID: 16898984 Partial author list: First Author & Affiliation: Tamuz, Michal; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070205. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Tamuz, Michal. Major Descriptor: Hospitals; Patients; Safety; Theories. Minor Descriptor: Patient Safety. Classification: Inpatient & Hospital Services (3379). Population: Human (10). References Available: Y. Page Count: 23. Issue Publication Date: Aug, 2006.
AB - Objective: To identify the distinctive contributions of high-reliability theory (HRT) and normal accident theory (NAT) as frameworks for examining five patient safety practices. Data Sources/Study Setting: We reviewed and drew examples from studies of organization theory and health services research. Study Design: After highlighting key differences between HRT and NAT, we applied the frames to five popular safety practices: double-checking medications, crew resource management (CRM), computerized physician order entry (CPOE), incident reporting, and root cause analysis (RCA). Principal Findings: HRT highlights how double checking, which is designed to prevent errors, can undermine mindfulness of risk. NAT emphasizes that social redundancy can diffuse and reduce responsibility for locating mistakes. CRM promotes high reliability organizations by fostering deference to expertise, rather than rank. However, HRT also suggests that effective CRM depends on fundamental changes in organizational culture. NAT directs attention to an underinvestigated feature of CPOE: it tightens the coupling of the medication ordering process, and tight coupling increases the chances of a rapid and hard-to-contain spread of infrequent, but harmful errors. Conclusions: Each frame can make a valuable contribution to improving patient safety. By applying the HRT and NAT frames, health care researchers and administrators can identify health care settings in which new and existing patient safety interventions are likely to be effective. Furthermore, they can learn how to improve patient safety, not only from analyzing mishaps, but also by studying the organizational consequences of implementing safety measures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospitals
KW - patient safety
KW - high-reliability theory
KW - normal accident theory
KW - 2006
KW - Hospitals
KW - Patients
KW - Safety
KW - Theories
KW - Patient Safety
KW - 2006
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 1PO1HS1154401. Recipients: Tamuz, Michal
DO - 10.1111/j.1475-6773.2006.00570.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-09809-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Roh, H.W.
AU - Lee, N.R.
AU - Cho, Y.H.
AU - Jung, J.B.
AU - Chung, H.N.
AU - Yang, W.S.
AU - Lee, W.K.
AU - Lee, H.K.
AU - Ryu, G.H.
T1 - Development of a guideline for protein chip evaluation as medical devices
JO - Current Applied Physics
JF - Current Applied Physics
Y1 - 2006/08/02/Aug2006 Supplement
VL - 6
M3 - Article
SP - e261
EP - e265
SN - 15671739
AB - Abstract: Protein chip technology can be applied to diagnosis of disease, prognosis, drug discovery, tailored drug therapy, screening of drug candidates and so on. A protein chip should be evaluated and approved as a medical device to be used as a diagnostic device before marketing. In this study, we prepared a cancer protein chip and evaluated it. From the results of this evaluation study, we developed the requirements and standards for protein chip evaluation as medical devices to guide how to prepare technical documents and what data should be submitted to verify the safety and effectiveness of a protein chip for industry and KFDA reviewer. The guideline was established with three areas; evaluation of quality control system, analytical, and clinical performance. First, quality control system should be evaluated in the aspect of material, manufacturing process, and final product. In addition, validation of expiration date and storing condition is needed to confirm the quality control system. Second, evaluation of analytical performance includes the validation of analytical sensitivity, reproducibility, specificity, and effectiveness of signal detecting instruments with related software. Third, clinical performance evaluation includes clinical sensitivity, specificity, and cut-off value. This guideline will be helpful for preparing and reviewing of diagnostic protein chip submission as medical devices and facilitating the commercialization of protein chips. [Copyright &y& Elsevier]
AB - Copyright of Current Applied Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - TESTING
KW - COMMERCIAL products
KW - DIAGNOSIS
KW - Evaluation
KW - Guideline
KW - Medical device
KW - Nanotechnology
KW - Performance
KW - Protein chip
N1 - Accession Number: 21749947; Roh, H.W. 1 Lee, N.R. 1 Cho, Y.H. 1 Jung, J.B. 1 Chung, H.N. 1 Yang, W.S. 1 Lee, W.K. 1 Lee, H.K. 1 Ryu, G.H.; Email Address: gyuha@kfda.go.kr; Affiliation: 1: Department of Medical Devices and Radiation Health, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Republic of Korea; Source Info: Aug2006 Supplement, Vol. 6, pe261; Subject Term: MEDICAL equipment; Subject Term: TESTING; Subject Term: COMMERCIAL products; Subject Term: DIAGNOSIS; Author-Supplied Keyword: Evaluation; Author-Supplied Keyword: Guideline; Author-Supplied Keyword: Medical device; Author-Supplied Keyword: Nanotechnology; Author-Supplied Keyword: Performance; Author-Supplied Keyword: Protein chip; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.cap.2006.01.052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21749947&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Haeng-Shin
AU - Cho, Yang-Hee
AU - Park, Seon-Oh
AU - Kye, Seung-Hee
AU - Kim, Bok-Hee
AU - Hahm, Tae-Shik
AU - Kim, Meehye
AU - Ok Lee, Jong
AU - Kim, Cho-il
T1 - Dietary exposure of the Korean population to arsenic, cadmium, lead and mercury
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2006/08/02/Aug2006 Supplement
VL - 19
M3 - Article
SP - S31
EP - S37
SN - 08891575
AB - Abstract: Due to increasing concern about the intake of contaminants in foods, this study was performed to monitor the exposure of the Korean population to heavy metal contaminants (arsenic, cadmium, mercury and lead) from typical diets, and to estimate the health risk. A food list representing typical dietary practices of Koreans was developed, based on the results of the 1998 National Health and Nutrition Survey and the 1999 Seasonal Nutrition Survey, which included a nationwide sample of 4000 and 3000 households, respectively, including everyone 1 year and older. Foods were prepared for consumption (table-ready) according to representative recipes and typical cooking methods, and were chemically analysed to measure the levels of heavy metals by inductively coupled plasma–emission spectrometry (arsenic, cadmium and lead) and gold amalgamation (mercury). Then, the dietary intake of each heavy metal was estimated based on the mean food intake of the population, and the associated risk was evaluated by comparing intakes with the provisional tolerable weekly intakes (PTWIs). Although seaweeds and fishes were highest in heavy metal content, the contribution of foods to total heavy metal intake was more influenced by the amount of food consumed, so that cooked rice was the most important contributor to mercury intake, and vegetables the most important contributor of lead. Nevertheless, the estimated dietary intakes of arsenic (38.5μg/person/day), cadmium (14.3μg/person/day), lead (24.4μg/person/day) and mercury (1.61μg/person/day) from the 116 foods tested were well within the safe limits (under 30% of PTWIs). It appears that there is no imminent health risk due to heavy metals examined in this study for the total diet of the Korean population. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Analysis
KW - FOOD contamination -- Prevention
KW - HEAVY metals
KW - KOREA
KW - Arsenic
KW - Cadmium
KW - Dietary intake
KW - Foods/dishes
KW - Lead
KW - Mercury
N1 - Accession Number: 20927575; Lee, Haeng-Shin 1 Cho, Yang-Hee 1 Park, Seon-Oh 1 Kye, Seung-Hee 1 Kim, Bok-Hee 2 Hahm, Tae-Shik 3 Kim, Meehye 4 Ok Lee, Jong 4 Kim, Cho-il 1; Email Address: kimci1956@yahoo.co.kr; Affiliation: 1: Korea Health Industry Development Institute, Seoul, Republic of Korea 2: Chosun University, Gwangju, Republic of Korea 3: Hanseo University, Seoul, Republic of Korea 4: Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Aug2006 Supplement, Vol. 19, pS31; Subject Term: FOOD -- Analysis; Subject Term: FOOD contamination -- Prevention; Subject Term: HEAVY metals; Subject Term: KOREA; Author-Supplied Keyword: Arsenic; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Dietary intake; Author-Supplied Keyword: Foods/dishes; Author-Supplied Keyword: Lead; Author-Supplied Keyword: Mercury; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2005.10.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=20927575&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dwyer, Johanna T.
AU - Frances Picciano, Mary
AU - Betz, Joseph M.
AU - Fisher, Kenneth D.
AU - Saldanha, Leila G.
AU - Yetley, Elizabeth A.
AU - Coates, Paul M.
AU - Radimer, Kathy
AU - Bindewald, Bernadette
AU - Sharpless, Katherine E.
AU - Holden, Joanne
AU - Andrews, Karen
AU - Zhao, Cuiwei
AU - Harnly, James
AU - Wolf, Wayne R.
AU - Perry, Charles R.
T1 - Progress in development of an integrated dietary supplement ingredient database at the NIH Office of Dietary Supplements
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2006/08/02/Aug2006 Supplement
VL - 19
M3 - Article
SP - S108
EP - S114
SN - 08891575
AB - Abstract: Several activities of the Office of Dietary Supplements (ODS) at the National Institutes of Health involve enhancement of dietary supplement databases. These include an initiative with US Department of Agriculture to develop an analytically substantiated dietary supplement ingredient database (DSID) and collaboration with the National Center for Health Statistics to enhance the dietary supplement label database in the National Health and Nutrition Examination Survey (NHANES). The many challenges that must be dealt with in developing an analytically supported DSID include categorizing product types in the database, identifying nutrients, and other components of public health interest in these products and prioritizing which will be entered in the database first. Additional tasks include developing methods and reference materials for quantifying the constituents, finding qualified laboratories to measure the constituents, developing appropriate sample handling procedures, and finally developing representative sampling plans. Developing the NHANES dietary supplement label database has other challenges such as collecting information on dietary supplement use from NHANES respondents, constant updating and refining of information obtained, developing default values that can be used if the respondent cannot supply the exact supplement or strength that was consumed, and developing a publicly available label database. Federal partners and the research community are assisting in making an analytically supported dietary supplement database a reality. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - DATABASE management
KW - PUBLIC health research
KW - UNITED States
KW - Analytical substantiation
KW - Certified reference materials
KW - Dietary supplement composition
KW - Dietary supplement ingredient database
KW - Dietary supplement labels
KW - Dietary supplements
KW - DSID
KW - NHANES
KW - Standard reference materials
N1 - Accession Number: 20927587; Dwyer, Johanna T. 1; Email Address: dwyerj1@od.nih.gov Frances Picciano, Mary 1 Betz, Joseph M. 2 Fisher, Kenneth D. 1 Saldanha, Leila G. 1 Yetley, Elizabeth A. 1 Coates, Paul M. 1 Radimer, Kathy 3 Bindewald, Bernadette 3 Sharpless, Katherine E. 4 Holden, Joanne 5 Andrews, Karen 5 Zhao, Cuiwei 5 Harnly, James 6 Wolf, Wayne R. 6 Perry, Charles R. 7; Affiliation: 1: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA 2: Dietary Supplement Methods and Reference Materials Program, Office of Dietary Supplements, National Institutes of Health, USA 3: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control, US Department of Health and Human Services, USA 4: National Institute of Standards and Technology, Gaithersburg, MD, USA 5: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, USA 6: Food Composition Laboratory, Agricultural Research Service, Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, MD, USA 7: Research and Development Division, National Agricultural Statistic Service, US Department of Agriculture Fairfax, VA, USA; Source Info: Aug2006 Supplement, Vol. 19, pS108; Subject Term: DIETARY supplements; Subject Term: DATABASE management; Subject Term: PUBLIC health research; Subject Term: UNITED States; Author-Supplied Keyword: Analytical substantiation; Author-Supplied Keyword: Certified reference materials; Author-Supplied Keyword: Dietary supplement composition; Author-Supplied Keyword: Dietary supplement ingredient database; Author-Supplied Keyword: Dietary supplement labels; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: DSID; Author-Supplied Keyword: NHANES; Author-Supplied Keyword: Standard reference materials; NAICS/Industry Codes: 518210 Data Processing, Hosting, and Related Services; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2005.09.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Okelo, P.O.
AU - Wagner, D.D.
AU - Carr, L.E.
AU - Wheaton, F.W.
AU - Douglass, L.W.
AU - Joseph, S.W.
T1 - Optimization of extrusion conditions for elimination of mesophilic bacteria during thermal processing of animal feed mash
JO - Animal Feed Science & Technology
JF - Animal Feed Science & Technology
Y1 - 2006/08/04/
VL - 129
IS - 1/2
M3 - Article
SP - 116
EP - 137
SN - 03778401
AB - Abstract: Salmonella and other pathogenic organisms that infect poultry and other livestock can originate from feed and environmental sources. Thus, measures are taken to control Salmonella infection in animals to improve food safety and reduce production losses. The current study was designed to investigate and optimize extrusion conditions for reducing bacterial counts in a surrogate feed matrix. A single-screw extruder was used to process feed artificially inoculated with Bacillus stearothermophilus 12980 (ATCC, Reston, Virginia). Preliminary experiments demonstrated that Salmonella typhimurium (S. typhimurium NALr) was eliminated from feed under conditions of moderate extrusion stringency (285g moisture/kg mash feed, 83°C extruder barrel exit temperature, 7s retention time in the extruder barrel) and, therefore, a more thermotolerant organism was required to conduct the study. Spores of B. stearothermophilus 12980 inoculated into a surrogate feed matrix consisting of 600g maize meal/kg, 300g soya bean meal/kg and 100g animal protein blend/kg, respectively, was used to investigate the effect of three extrusion variables on microbial killing. The three variables were extruder barrel exit temperature (T), mash feed moisture content (M c), and mean retention time of feed in the extruder barrel (R t). A rotatable central composite statistical design was used with three independent variables and five levels each. The quadratic response surface model fit to spore count data was used to predict extrusion conditions that maximized bacterial killing. The response surface indicated a stationary point within the design region that was a saddle. An estimated ridge of maximum killing indicated that a maximum reduction of 1.03 log cycles would occur under the following extruder settings: T =110°C, M c =245g/kg and R t =11s. Because the moderate stringency condition (T =83°C, M c =285g/kg and R t =7s) completely eliminated detectable S. typhimurium in the test feed matrix, it would appear that all S. typhimurium cells and all mesophilic organisms of similar thermal tolerance would be eliminated at most extruder conditions within the central composite design region. [Copyright &y& Elsevier]
AB - Copyright of Animal Feed Science & Technology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVESTOCK
KW - ENTEROBACTERIACEAE
KW - SALMONELLA typhimurium
KW - MOISTURE
KW - Bacillus stearothermophilus
KW - Bacteria
KW - Extrusion
KW - Feeds
KW - Mash
KW - Salmonella typhimurium
KW - Thermal processing
N1 - Accession Number: 21339197; Okelo, P.O. 1; Email Address: Phares.Okelo@fda.gov Wagner, D.D. 2 Carr, L.E. 3 Wheaton, F.W. 3 Douglass, L.W. 4 Joseph, S.W. 5; Affiliation: 1: Center for Veterinary Medicine, US Food and Drug Administration, Rockville, MD 20855, United States 2: Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, United States 3: Biological Resources Engineering Department, University of Maryland, College Park, MD 20742, United States 4: Animal and Avian Sciences Department, University of Maryland, College Park, MD 20742, United States 5: Cell Biology and Molecular Genetics Department, University of Maryland, College Park, MD 20742, United States; Source Info: Aug2006, Vol. 129 Issue 1/2, p116; Subject Term: LIVESTOCK; Subject Term: ENTEROBACTERIACEAE; Subject Term: SALMONELLA typhimurium; Subject Term: MOISTURE; Author-Supplied Keyword: Bacillus stearothermophilus; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Extrusion; Author-Supplied Keyword: Feeds; Author-Supplied Keyword: Mash; Author-Supplied Keyword: Salmonella typhimurium; Author-Supplied Keyword: Thermal processing; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.anifeedsci.2005.12.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kozlowski, Steven
AU - Swann, Patrick
T1 - Current and future issues in the manufacturing and development of monoclonal antibodies
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2006/08/07/
VL - 58
IS - 5/6
M3 - Article
SP - 707
EP - 722
SN - 0169409X
AB - Abstract: Despite a slow beginning, monoclonal antibodies have had many successes over the past decade. It is important that these successes continue, bringing more products for more indications to market. Although manufacturing is not the most common cause of product failure, product quality issues can delay antibody development. Manufacturing has depended on the triad of process validation, process control and product testing. Applying product knowledge proactively to manufacturing (quality by design) may allow greater flexibility and maintain or improve product quality. An integrated approach to biological characterization is an important aspect of product knowledge. Greater product knowledge also facilitates development in other disciplines. Independent of manufacturing strategy, there are a number of regulatory hurdles in initial and ongoing antibody development. These are described to help prevent unnecessary delays. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - QUALITY of products
KW - MOLECULAR cloning
KW - CONTROL theory (Mathematics)
KW - Biological characterization
KW - Manufacturing
KW - Monoclonal antibodies
KW - Product testing
KW - Quality by design
N1 - Accession Number: 22081786; Kozlowski, Steven 1; Email Address: steven.kozlowski@fda.hhs.gov Swann, Patrick 2; Affiliation: 1: Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Division of Monoclonal Antibodies, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Aug2006, Vol. 58 Issue 5/6, p707; Subject Term: MONOCLONAL antibodies; Subject Term: QUALITY of products; Subject Term: MOLECULAR cloning; Subject Term: CONTROL theory (Mathematics); Author-Supplied Keyword: Biological characterization; Author-Supplied Keyword: Manufacturing; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: Product testing; Author-Supplied Keyword: Quality by design; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.addr.2006.05.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huang, Ying
AU - Sadée, Wolfgang
T1 - Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2006/08/08/
VL - 239
IS - 2
M3 - Article
SP - 168
EP - 182
SN - 03043835
AB - Abstract: Membrane transporters play important roles in mediating chemosensitivity and -resistance of tumor cells. ABC transporters, such as ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP, are frequently associated with decreased cellular accumulation of anticancer drugs and multidrug resistance of tumors. SLC transporters, such as folate, nucleoside, and amino acid transporters, commonly increase chemosensitivity by mediating the cellular uptake of hydrophilic drugs. Ion channels and pumps variably affect sensitivity to anticancer therapy by modulating viability of tumor cells. A pharmacogenomic approach, using correlations between drug potency and transporter gene expression in multiple cancer cell lines, has shown promise for identifying potential drug–transporter relationships and predicting anticancer drug response, in an effort to optimize chemotherapy for individual patients. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THERAPEUTICS
KW - CANCER patients
KW - DRUG therapy
KW - CANCER cells
KW - ABC transporter
KW - ATP-binding cassette ( ABC )
KW - Chemoresistance
KW - Chemosensitivity
KW - heterodimeric amino acid transporters ( HAT )
KW - Ion channel
KW - Membrane transporter
KW - multidrug resistance ( MDR )
KW - nitrobenzylthioinosine ( NBMPR )
KW - RNA interference ( RNAi )
KW - single-nucleotide polymorphisms ( SNPs )
KW - SLC transporter
KW - small interfering RNA ( siRNA )
KW - solute carriers ( SLC )
KW - the National Cancer Institute ( NCI )
N1 - Accession Number: 21495444; Huang, Ying 1; Email Address: yhuang@nctr.fda.gov Sadée, Wolfgang 2; Affiliation: 1: Food and Drug Administration, Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Program of Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA; Source Info: Aug2006, Vol. 239 Issue 2, p168; Subject Term: THERAPEUTICS; Subject Term: CANCER patients; Subject Term: DRUG therapy; Subject Term: CANCER cells; Author-Supplied Keyword: ABC transporter; Author-Supplied Keyword: ATP-binding cassette ( ABC ); Author-Supplied Keyword: Chemoresistance; Author-Supplied Keyword: Chemosensitivity; Author-Supplied Keyword: heterodimeric amino acid transporters ( HAT ); Author-Supplied Keyword: Ion channel; Author-Supplied Keyword: Membrane transporter; Author-Supplied Keyword: multidrug resistance ( MDR ); Author-Supplied Keyword: nitrobenzylthioinosine ( NBMPR ); Author-Supplied Keyword: RNA interference ( RNAi ); Author-Supplied Keyword: single-nucleotide polymorphisms ( SNPs ); Author-Supplied Keyword: SLC transporter; Author-Supplied Keyword: small interfering RNA ( siRNA ); Author-Supplied Keyword: solute carriers ( SLC ); Author-Supplied Keyword: the National Cancer Institute ( NCI ); Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.canlet.2005.07.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bo Li
AU - Genevieve Sauvé
AU - Mihaela C. Iovu
AU - Malika Jeffries-EL
AU - Rui Zhang
AU - Jessica Cooper
AU - Suresh Santhanam
AU - Lawrence Schultz
AU - Joseph C. Revelli
AU - Aaron G. Kusne
AU - Tomasz Kowalewski
AU - Jay L. Snyder
AU - Lee E. Weiss
AU - Gary K. Fedder
AU - Richard D. McCullough
AU - David N. Lambeth
T1 - Volatile Organic Compound Detection Using Nanostructured Copolymers.
JO - Nano Letters
JF - Nano Letters
Y1 - 2006/08/09/
VL - 6
IS - 8
M3 - Article
SP - 1598
EP - 1602
SN - 15306984
AB - Regioregular polythiophene-based conductive copolymers with highly crystalline nanostructures are shown to hold considerable promise as the active layer in volatile organic compound (VOC) chemresistor sensors. While the regioregular polythiophene polymer chain provides a charge conduction path, its chemical sensing selectivity and sensitivity can be altered either by incorporating a second polymer to form a block copolymer or by making a random copolymer of polythiophene with different alkyl side chains. The copolymers were exposed to a variety of VOC vapors, and the electrical conductivity of these copolymers increased or decreased depending upon the polymer composition and the specific analytes. Measurements were made at room temperature, and the responses were found to be fast and appeared to be completely reversible. Using various copolymers of polythiophene in a sensor array can provide much better discrimination to various analytes than existing solid state sensors. Our data strongly indicate that several sensing mechanisms are at play simultaneously, and we briefly discuss some of them. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nano Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOSTRUCTURES
KW - COPOLYMERS
KW - VOLATILE organic compounds
KW - CHEMICAL detectors
N1 - Accession Number: 22094949; Bo Li 1 Genevieve Sauvé 1 Mihaela C. Iovu 1 Malika Jeffries-EL 1 Rui Zhang 1 Jessica Cooper 1 Suresh Santhanam 1 Lawrence Schultz 1 Joseph C. Revelli 1 Aaron G. Kusne 1 Tomasz Kowalewski 1 Jay L. Snyder 1 Lee E. Weiss 1 Gary K. Fedder 1 Richard D. McCullough 1 David N. Lambeth 1; Affiliation: 1: Electrical and Computer Engineering Department, Chemistry Department, RoboticsInstitute, and Chemical Engineering Department, Carnegie Mellon University,Pittsburgh, Pennsylvania 15213, and National Personal Protective TechnologyLaboratory, National Institute for Occupational Safety and Health, Pittsburgh,Pennsylvania 15236; Source Info: Aug2006, Vol. 6 Issue 8, p1598; Subject Term: NANOSTRUCTURES; Subject Term: COPOLYMERS; Subject Term: VOLATILE organic compounds; Subject Term: CHEMICAL detectors; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Jader, Layla
T1 - Why it really is time to separate from direct government involvement.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2006/08/12/
VL - 333
IS - 7563
M3 - Letter
SP - 354
EP - 354
SN - 09598146
AB - A response by Layla Jader to letters she received about her article "It is time to separate the NHS from direct government involvement," in the June 24, 2006 issue is presented.
KW - LETTERS to the editor
KW - GREAT Britain. National Health Service
N1 - Accession Number: 22026657; Jader, Layla 1; Email Address: Layla.]ader@nphs.wales.nhs.uk; Affiliation: 1: Consultant in Public Health Medicine, National Public Health Service for Wales, Cardiff CF10 3NW; Source Info: 8/12/2006, Vol. 333 Issue 7563, p354; Subject Term: LETTERS to the editor; Company/Entity: GREAT Britain. National Health Service; Number of Pages: 1/3p; Illustrations: 1 Color Photograph; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106284108
T1 - Putting prevention into practice: an evidence-based approach. Screening for peripheral arterial disease.
AU - Wolff TA
AU - Gutke GD
Y1 - 2006/08/15/
N1 - Accession Number: 106284108. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Peripheral Vascular Diseases -- Prevention and Control
KW - Arterial Occlusive Diseases -- Prevention and Control
KW - Arterial Occlusive Diseases -- Ultrasonography
KW - Education, Continuing (Credit)
KW - Male
KW - Middle Age
KW - Peripheral Vascular Diseases -- Ultrasonography
SP - 635
EP - 677
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 74
IS - 4
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Medical Officer, US Preventive Services Task Force Program, Agency for Healthcare Research and Quality
U2 - PMID: 16939187.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106139907
T1 - Birth weight and mortality: causality or confounding?
AU - Basso O
AU - Wilcox AJ
AU - Weinberg CR
Y1 - 2006/08/15/
N1 - Accession Number: 106139907. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Commentary: Schisterman EF, Hernández-Díaz S. Invited commentary: simple models for a complicated reality. (AM J EPIDEMIOL) Aug2006; 164 (4): 312-314. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Grant Information: Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. NLM UID: 7910653.
KW - Birth Weight
KW - Infant Mortality
KW - Causal Attribution
KW - Childbirth, Premature -- Mortality
KW - Confounding Variable
KW - Female
KW - Fetal Growth Retardation -- Etiology
KW - Fetal Growth Retardation -- Mortality
KW - Funding Source
KW - Infant, Newborn
KW - Pregnancy
KW - Smoking
KW - Smoking -- Epidemiology
KW - Human
SP - 303
EP - 311
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 164
IS - 4
PB - Oxford University Press / USA
AB - The association between birth weight and mortality is among the strongest seen in epidemiology. While preterm delivery causes both small babies and high mortality, it does not explain this association. Fetal growth restriction has also been proposed, although its features are unclear because it lacks a definition independent of weight. If, as some postulate, birth weight is not itself on the causal path to mortality, its relation with mortality would have to be explained by confounding factors that decrease birth weight and increase mortality. In this paper, the authors explore the characteristics such confounders would require in order to achieve the observed association between birth weight and mortality. Through a simple simulation, they found that the observed steep gradient of risk for small babies at term can be produced by a rare condition or conditions (with a total prevalence of 0.5%) having profound effects on both fetal growth (-1.7 standard deviations) and mortality (relative risk = 160). Candidate conditions might include malformations, fetal or placental aneuploidy, infections, or imprinting disorders. If such rare factors underlie the association of birth weight with mortality, it would have broad implications for the study of fetal growth restriction and birth weight, and for the prevention of infant mortality.
SN - 0002-9262
AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC.
U2 - PMID: 16847040.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106139907&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhenqiang Su
AU - Weida Tong
AU - Leming Shi
AU - Xueguang Shao
AU - Wensheng Cai
T1 - A Partial Least Squares‐Based Consensus Regression Method for the Analysis of Near‐Infrared Complex Spectral Data of Plant Samples.
JO - Analytical Letters
JF - Analytical Letters
Y1 - 2006/08/15/
VL - 39
IS - 9
M3 - Article
SP - 2073
EP - 2083
PB - Taylor & Francis Ltd
SN - 00032719
AB - A consensus regression approach based on partial least square (PLS) regression, named as cPLS, for calibrating the NIR data was investigated. In this approach, multiple independent PLS models were developed and integrated into a single consensus model. The utility and merits of the cPLS method were demonstrated by comparing its results with those from a regular PLS method in predicting moisture, oil, protein, and starch contents of corn samples using the NIR spectral data. It was found that cPLS was superior to regular PLS with respect to prediction accuracy and robustness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Letters is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - CALIBRATION
KW - CORN
KW - MOISTURE
KW - PROTEINS
KW - STARCH
KW - consensus modeling
KW - multivariate calibration
KW - Near‐infrared spectroscopy
KW - Near-infrared spectroscopy
KW - partial least squares
N1 - Accession Number: 21894789; Zhenqiang Su 1,2 Weida Tong 2 Leming Shi 2 Xueguang Shao 1,3 Wensheng Cai 1,3; Email Address: wscai@ustc.edu.cn; Affiliation: 1: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China. 2: Center for Toxico-informatics, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), Jefferson, AZ, USA. 3: Department of Chemistry, Nankai University, Tianjin, P. R. China.; Source Info: 2006, Vol. 39 Issue 9, p2073; Subject Term: REGRESSION analysis; Subject Term: CALIBRATION; Subject Term: CORN; Subject Term: MOISTURE; Subject Term: PROTEINS; Subject Term: STARCH; Author-Supplied Keyword: consensus modeling; Author-Supplied Keyword: multivariate calibration; Author-Supplied Keyword: Near‐infrared spectroscopy; Author-Supplied Keyword: Near-infrared spectroscopy; Author-Supplied Keyword: partial least squares; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 311221 Wet Corn Milling; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/00032710600724088
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21894789&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schmitt, T.C.
AU - Biris, A.S.
AU - Miller, D.W.
AU - Biris, A.R.
AU - Lupu, D.
AU - Trigwell, S.
AU - Rahman, Z.U.
T1 - Analysis of effluent gases during the CCVD growth of multi-wall carbon nanotubes from acetylene
JO - Carbon
JF - Carbon
Y1 - 2006/08/15/
VL - 44
IS - 10
M3 - Article
SP - 2032
EP - 2038
SN - 00086223
AB - Abstract: Catalytic chemical vapor deposition was used to grow multi-walled carbon nanotubes on a Fe:Co:CaCO3 catalyst from acetylene. The influent and effluent gases were analyzed by gas chromatography and mass spectrometry at different time intervals during the nanotubes growth process in order to better understand and optimize the overall reaction. A large number of byproducts were identified and it was found that the number and the level for some of the carbon byproducts significantly increased over time. The CaCO3 catalytic support thermally decomposed into CaO and CO2 resulting in a mixture of two catalysts for growing the nanotubes, which were found to have outer diameters belonging to two main groups 8–35nm and 40–60nm, respectively. [Copyright &y& Elsevier]
AB - Copyright of Carbon is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICAL vapor deposition
KW - CATALYSIS
KW - CARBON
KW - NANOTUBES
KW - GAS chromatography
KW - Carbon nanotubes
KW - Catalytic chemical vapor deposition
KW - Chromatography
KW - Thermodynamic analysis
N1 - Accession Number: 21075767; Schmitt, T.C. 1; Email Address: tschmitt@nctr.fda.gov Biris, A.S. 2 Miller, D.W. 1 Biris, A.R. 3 Lupu, D. 3 Trigwell, S. 4 Rahman, Z.U. 5; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA 2: University of Arkansas at Little Rock, Graduate Institute of Technology, UALR Center of Nanotechnology, Little Rock, AR 72204, USA 3: National Institute for Research and Development of Isotopic and Molecular Technologies, P.O. Box 700, R-400293, Cluj-Napoca, Romania 4: Electrostatics and Surface Physics Laboratory, Mail Code: YA-C2-T, Kennedy Space Center, NASA, FL 32899, USA 5: Advanced Materials Processing and Analysis Center, University of Central Florida, 12443 Research Parkway, Suite 304, Orlando, FL 32826, USA; Source Info: Aug2006, Vol. 44 Issue 10, p2032; Subject Term: CHEMICAL vapor deposition; Subject Term: CATALYSIS; Subject Term: CARBON; Subject Term: NANOTUBES; Subject Term: GAS chromatography; Author-Supplied Keyword: Carbon nanotubes; Author-Supplied Keyword: Catalytic chemical vapor deposition; Author-Supplied Keyword: Chromatography; Author-Supplied Keyword: Thermodynamic analysis; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.carbon.2006.01.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21075767&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stultz, Brian G.
AU - Lee, Heuijung
AU - Ramon, Karolyn
AU - Hursh, Deborah A.
T1 - Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head
JO - Developmental Biology
JF - Developmental Biology
Y1 - 2006/08/15/
VL - 296
IS - 2
M3 - Article
SP - 329
EP - 339
SN - 00121606
AB - Abstract: Drosophila adult structures derive from imaginal discs, which are sacs with apposed epithelial sheets, the disc proper (DP) and the peripodial epithelium (PE). The Drosophila TGF-β family member decapentaplegic (dpp) contributes to the development of adult structures through expression in all imaginal discs, driven by enhancers from the 3′ cis-regulatory region of the gene. In the eye/antennal disc, there is 3′ directed dpp expression in both the DP and PE associated with cell proliferation and eye formation. Here, we analyze a new class of dpp cis-regulatory mutations, which specifically disrupt a previously unknown region of dpp expression, controlled by enhancers in the 5′ regulatory region of the gene and limited to the PE of eye/antennal discs. These are the first described Drosophila mutations that act by solely disrupting PE gene expression. The mutants display defects in the ventral adult head and alter peripodial but not DP expression of known dpp targets. However, apoptosis is observed in the underlying DP, suggesting that this peripodial dpp signaling source supports cell survival in the DP. [Copyright &y& Elsevier]
AB - Copyright of Developmental Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DROSOPHILA
KW - CELL division (Biology)
KW - CELL proliferation
KW - CELLULAR growth
KW - Decapentaplegic
KW - dpp
KW - Drosophila
KW - Head capsule
KW - Peripodial epithelium
KW - TGF-β
N1 - Accession Number: 21912969; Stultz, Brian G. 1 Lee, Heuijung Ramon, Karolyn 1 Hursh, Deborah A.; Email Address: deborah.hursh@fda.hhs.gov; Affiliation: 1: Division of Cell and Gene Therapy, Cellular and Tissue Therapy Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-740, Bldg. 29B, Rm. 1E16, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Aug2006, Vol. 296 Issue 2, p329; Subject Term: DROSOPHILA; Subject Term: CELL division (Biology); Subject Term: CELL proliferation; Subject Term: CELLULAR growth; Author-Supplied Keyword: Decapentaplegic; Author-Supplied Keyword: dpp; Author-Supplied Keyword: Drosophila; Author-Supplied Keyword: Head capsule; Author-Supplied Keyword: Peripodial epithelium; Author-Supplied Keyword: TGF-β; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ydbio.2006.05.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21912969&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feng, Rentian
AU - He, Wei
AU - Ochi, Hirotomo
AU - Castranova, Vincent
T1 - Ozone Exposure Impairs Antigen-Specific Immunity but Activates IL-7-Induced Proliferation of CD4 - CD8 - Thymocytes in Balb/ c Mice.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2006/08/15/
VL - 69
IS - 16
M3 - Article
SP - 1511
EP - 1526
SN - 15287394
AB - It is well known that ozone (O 3 ), a potent reactive oxidant and air pollutant, induces respiratory inflammation and hyperresponsiveness upon inhalation. It was previously shown that O 3 exposure (0.6 ppm, 10 h/day for 15 days) not only results in local bronchial inflammation, but also affects the nervous system and thymocyte proliferation, and places mice under oxidative stress. In the present study, data showed that O 3 exposure could impair both the natural killer (NK) cell activity and the proliferation potential of spleen T cells to a specific antigen stimulus. Immunological function assays indicated that O 3 exposure attenuated the proliferation of spleen mononuclear cells induced by concanavalin A and decreased CD4 + and CD28 + lymphocyte subsets. However, supplementation with natural antioxidants protected mice from O 3 -induced dysfunction of splenocyte proliferation. Meanwhile, O 3 exposure resulted in a decline of mitogen-induced IL-2 production in splenocytes. It was also found that O 3 exposure dramatically enhanced the proliferation of CD4 - CD8 - thymocytes stimulated by recombinant mouse interleukin-7 (rmIL-7), which is usually observed during the mammal aging process. Taken together, data conclude that short-term repetitive O 3 exposure damages both innate and acquired immunity via altering the lymphocyte subset and cytokine profile, and via impact on thymocyte early development. O 3 -induced oxidative damage is one of the key factors leading to immune dysfunction in this mouse model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR pollution
KW - RESPIRATORY infections
KW - INTERLEUKINS
KW - RESPIRATORY diseases
KW - IMMUNOLOGIC diseases
KW - KILLER cells
KW - OXIDATIVE stress
KW - OXIDATION-reduction reaction
KW - STRESS (Physiology)
N1 - Accession Number: 21807863; Feng, Rentian He, Wei 1 Ochi, Hirotomo 1 Castranova, Vincent 2; Affiliation: 1: Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Aug2006, Vol. 69 Issue 16, p1511; Subject Term: AIR pollution; Subject Term: RESPIRATORY infections; Subject Term: INTERLEUKINS; Subject Term: RESPIRATORY diseases; Subject Term: IMMUNOLOGIC diseases; Subject Term: KILLER cells; Subject Term: OXIDATIVE stress; Subject Term: OXIDATION-reduction reaction; Subject Term: STRESS (Physiology); Number of Pages: 15p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1080/15287390500468696
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21807863&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, John
AU - Tsai, Chen-An
AU - Chen, James
AU - Latendresse, John
AU - Kodell, Ralph
T1 - Database Composition Can Affect the Structure–Activity Relationship Prediction.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2006/08/15/
VL - 69
IS - 16
M3 - Article
SP - 1527
EP - 1540
SN - 15287394
AB - The percent active (A) and inactive (I) chemicals in a database can directly affect the sensitivity (% active chemicals predicted correctly) and specificity (% inactive chemicals predicted correctly) of structure–activity relationship (SAR) analyses. Subdividing the National Center for Toxicological Research (NCTR) liver cancer database (NCTRlcdb) into various A/I ratios, which varied from 0.2 to 5.5, resulted in sensitivity/specificity ratios that varied from 0.1 to 6.5. As percent active chemicals increased (increasing A/I ratio), the sensitivity rose, the specificity decreased, and the concordance (% total chemicals predicted correctly) remained fairly constant. The numbers of chemicals in the various data sets ranged from 187 to 999 and appeared to have no affect on any of the 3 predictors of sensitivity, specificity, or concordance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - HEPATOTOXICOLOGY
KW - LIVER -- Cancer
KW - LIVER diseases
KW - TOXICOLOGY
KW - CHEMICALS
KW - CLINICAL toxicology
KW - PAPER chemicals
KW - BIOACTIVE compounds
N1 - Accession Number: 21807861; Young, John 1; Email Address: jyoung@nctr.fda.gov Tsai, Chen-An 2 Chen, James 1 Latendresse, John 3 Kodell, Ralph 1; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA 2: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan 3: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Aug2006, Vol. 69 Issue 16, p1527; Subject Term: DATABASES; Subject Term: HEPATOTOXICOLOGY; Subject Term: LIVER -- Cancer; Subject Term: LIVER diseases; Subject Term: TOXICOLOGY; Subject Term: CHEMICALS; Subject Term: CLINICAL toxicology; Subject Term: PAPER chemicals; Subject Term: BIOACTIVE compounds; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 13p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390500468746
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21807861&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atenstaedt, R. L.
T1 - The medical response to trench nephritis in World War One.
JO - Kidney International
JF - Kidney International
Y1 - 2006/08/15/
VL - 70
IS - 4
M3 - Article
SP - 635
EP - 640
SN - 00852538
AB - Around the 90-year anniversary of the Battle of the Somme, it is important to remember the international effort that went into responding to the new diseases, which appeared during the First World War, such as trench nephritis. This condition arose among soldiers in spring 1915, characterized by breathlessness, swelling of the face or legs, headache, sore throat, and the presence of albumin and renal casts in urine. It was speedily investigated by the military-medical authorities. There was debate over whether it was new condition or streptococcal nephritis, and the experts agreed that it was a new condition. The major etiologies proposed were infection, exposure, and diet (including poisons). Research pointed to the origin of the disease as being infective rather than toxic, but no definite cause was discovered. A number of labels were given to the disease, including war nephritis. However, trench nephritis was the one used most widely. Trench nephritis was a serious problem for the Allies, leading to 35 000 casualties in the British and 2000 in the American forces. There were also hundreds of deaths. The condition was treated in line with pre-war regimens designed for acute nephritis. No significant preventative methods were implemented for trench nephritis, as there was no consensus regarding causation. The medical response to trench nephritis was largely ineffective, with medical commentators recognizing that there had been a lack of medical progress.Kidney International (2006) 70, 635–640. doi:10.1038/sj.ki.5001618; published online 5 July 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KIDNEY diseases
KW - DYSPNEA
KW - EDEMA
KW - STREPTOCOCCAL diseases
KW - ALBUMINS
KW - DISEASES -- Causes & theories of causation
KW - hantavirus
KW - military personnel
KW - nephritis
KW - World War I
N1 - Accession Number: 21944785; Atenstaedt, R. L. 1; Email Address: Robert.Atenstaedt@nphs.wales.nhs.uk; Affiliation: 1: National Public Health Service for Wales and Institute of Medical and Social Care Research (IMSCaR), University of Wales, Bangor, UK; Source Info: Aug2006, Vol. 70 Issue 4, p635; Subject Term: KIDNEY diseases; Subject Term: DYSPNEA; Subject Term: EDEMA; Subject Term: STREPTOCOCCAL diseases; Subject Term: ALBUMINS; Subject Term: DISEASES -- Causes & theories of causation; Author-Supplied Keyword: hantavirus; Author-Supplied Keyword: military personnel; Author-Supplied Keyword: nephritis; Author-Supplied Keyword: World War I; Number of Pages: 6p; Document Type: Article
L3 - 10.1038/sj.ki.5001618
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21944785&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huffman, L.J.
AU - Beighley, C.M.
AU - Frazer, D.G.
AU - McKinney, W.G.
AU - Porter, D.W.
T1 - Increased susceptibility of the lungs of hyperthyroid rats to oxidant injury: Specificity of effects
JO - Toxicology
JF - Toxicology
Y1 - 2006/08/15/
VL - 225
IS - 2/3
M3 - Article
SP - 119
EP - 127
SN - 0300483X
AB - Abstract: Results from previous studies indicate that hyperthyroidism increases the risk of ozone-induced lung toxicity. This observation raised the possibility that pulmonary damage from other oxidant substances might be greater in a hyperthyroid state. To address this hypothesis, pulmonary responses to crystalline silica, a particulate with oxidant properties, were evaluated in normal or hyperthyroid adult male rats. To induce a hyperthyroid condition, time-release pellets containing thyroxine were implanted subcutaneously; control rats received placebo pellets. After 7 days, the animals were exposed to saline or silica (0.1mg/100g BW or 1.0mg/100g BW) by intratracheal instillation. Following silica treatment, there was a dose-related increase in bronchoalveolar lavage (BAL) albumin levels and neutrophil numbers. However, the effects of silica were similar in both normal and hyperthyroid rats. These findings were confirmed and contrasted with those regarding ozone (1ppm, 4h inhalation) in a subsequent experiment. The results indicated that, although exposure to either ozone or silica resulted in increases in BAL albumin levels and neutrophil numbers, only responses to ozone were enhanced in hyperthyroid rats. These findings suggest that specificity exists in regards to the modulation of oxidant-induced lung damage and inflammation by thyroid hormones. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS
KW - RATS
KW - OXIDIZING agents
KW - SILICA
KW - Ozone
KW - Rat
KW - Silica
KW - Thyroid hormone
N1 - Accession Number: 21741874; Huffman, L.J. 1,2 Beighley, C.M. 1 Frazer, D.G. 1,2 McKinney, W.G. 1 Porter, D.W. 1,2; Email Address: DPorter@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S 2015, 1095 Willowdale Road, Morgantown, WV 26505, United States 2: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States; Source Info: Aug2006, Vol. 225 Issue 2/3, p119; Subject Term: LUNGS; Subject Term: RATS; Subject Term: OXIDIZING agents; Subject Term: SILICA; Author-Supplied Keyword: Ozone; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Silica; Author-Supplied Keyword: Thyroid hormone; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2006.05.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21741874&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fedan, J.S.
AU - Dowdy, J.A.
AU - Fedan, K.B.
AU - Hubbs, A.F.
T1 - Popcorn worker's lung: In vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2006/08/15/
VL - 215
IS - 1
M3 - Article
SP - 17
EP - 22
SN - 0041008X
AB - Abstract: Workers who inhale microwave popcorn butter flavorings experience decrements in lung function and can develop clinical bronchiolitis obliterans, i.e., “popcorn worker''s lung” (Kreiss, K., Gomaa, A., Kullman, G., Fedan, K., Simoes, E.J., Enright, P.L., 2002. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 347, 330–338.). In a rat inhalation model, vapors of an artificial butter flavoring damaged the epithelium of the upper and lower airways (Hubbs, A.F., Battelli, L.A., Goldsmith, W.T., Porter, D.W., Frazer, D., Friend, S., Schwegler-Berry, D., Mercer, R.R., Reynolds, J.S., Grote, A., Castranova, V., Kullman, G., Fedan, J.S., Dowdy, J., Jones, W.G., 2002. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol. Appl. Pharmacol. 185, 128–135.). Diacetyl, a butter flavoring component, is a major volatile ketone in the popcorn-processing workplace. We investigated the effects of diacetyl on epithelium of guinea pig isolated airway preparations and the effects of diacetyl in vitro on reactivity to bronchoactive agents. In the isolated, perfused trachea preparation, diacetyl added to the intraluminal (mucosal) bath elicited responses that began with contraction (threshold ca. 3 mM) and ended with relaxation. After a 4-h incubation with intraluminal diacetyl (3 mM), contractions to extraluminal (serosal) methacholine (MCh) were slightly increased; however, sensitivity to intraluminally (mucosally) applied MCh was increased by 10-fold. Relaxation responses of MCh (3 × 10−7 M)-contracted tracheas to extraluminally applied terbutaline and intraluminally applied 120 mM KCl, to evoke epithelium-derived relaxing factor release, were unaffected by diacetyl. Exposure of the tracheal epithelium in Ussing chambers to diacetyl decreased transepithelial potential difference and resistance. These findings suggest that diacetyl exposure compromised epithelial barrier function, leading to hyperreactivity to mucosally applied MCh. The respiratory epithelium appears to serve as an initial target for the toxic effects of diacetyl in the airways. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THROAT
KW - EPITHELIUM
KW - GUINEA pigs
KW - RELAXATION (Health)
KW - Airway reactivity
KW - Bioelectric properties
KW - Diacetyl
KW - Epithelium
KW - Guinea pig
KW - Methacholine
KW - Perfused trachea
KW - Popcorn worker's lung
KW - Terbutaline
KW - Trachea
N1 - Accession Number: 21775475; Fedan, J.S. 1; Email Address: jsf2@cdc.gov Dowdy, J.A. 1 Fedan, K.B. 2 Hubbs, A.F. 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA 2: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Aug2006, Vol. 215 Issue 1, p17; Subject Term: THROAT; Subject Term: EPITHELIUM; Subject Term: GUINEA pigs; Subject Term: RELAXATION (Health); Author-Supplied Keyword: Airway reactivity; Author-Supplied Keyword: Bioelectric properties; Author-Supplied Keyword: Diacetyl; Author-Supplied Keyword: Epithelium; Author-Supplied Keyword: Guinea pig; Author-Supplied Keyword: Methacholine; Author-Supplied Keyword: Perfused trachea; Author-Supplied Keyword: Popcorn worker's lung; Author-Supplied Keyword: Terbutaline; Author-Supplied Keyword: Trachea; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.taap.2006.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21775475&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaoqing He
AU - Chen, Michael G.
AU - Lin, Gary X.
AU - Qiang Ma
T1 - Arsenic Induces NAD(P)H-quinone Oxidoreductase I by Disrupting the Nrf2·Keap1·Cul3 Complex and Recruiting Nrf2·Maf to the Antioxidant Response Element Enhancer.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/08/18/
VL - 281
IS - 33
M3 - Article
SP - 23620
EP - 23631
SN - 00219258
AB - The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adaptive responses in mammalian species. The biological targets of arsenic are largely unknown at present. We analyzed the signaling pathway for induction of detoxification gene NAD(P)H-quinone oxidoreductase (Nqo1) by arsenic. Genetic and biochemical evidence revealed that induction required cap 'n' collar basic leucine zipper transcription factor Nrf2 and the antioxidant response element (ARE) of Nqo1. Arsenic stabilized Nrf2 protein, extending the t1/2 of Nrf2 from 21 to 200 mm by inhibiting the Keap1·Cul3-dependent ubiquitination and proteasomal turnover of Nrf2. Arsenic markedly inhibited the ubiquitination of Nrf2 but did not disrupt the Nrf2·Keap1·Cul3 association in the cytoplasm. In the nucleus, arsenic, but not phenolic antioxidant tert-butylhydroquinone, dissociated Nrf2 from Keap1 and Cul3 followed by dimerization of Nrf2 with a Maf protein (Maf G/Maf K). Chromatin immunoprecipitation demonstrated that Nrf2 and Maf associated with the endogenous Nqo1 ARE enhancer constitutively. Arsenic substantially increased the ARE occupancy by Nrf2 and Maf. In addition, Keap1 was shown to be ubiquitinated in the cytoplasm and deubiquitinated in the nucleus in the presence of arsenic without changing the protein level, implicating nuclear-cytoplasmic recycling of Keap1. Our data reveal that arsenic activates the Nrf2/Keap1 signaling pathway through a distinct mechanism from that by antioxidants and suggest an "on-switch" model of Nqo1 transcription in which the binding of Nrf2·Maf to ARE controls both the basal and inducible expression of Nqo1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARSENIC
KW - QUINONE
KW - OXIDOREDUCTASES
KW - SEMIMETALS
KW - ENZYMES
KW - NATIVE element minerals
N1 - Accession Number: 22326744; Xiaoqing He 1 Chen, Michael G. 1 Lin, Gary X. 1 Qiang Ma 1; Email Address: qam1@cdc.gov; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Source Info: 8/18/2006, Vol. 281 Issue 33, p23620; Subject Term: ARSENIC; Subject Term: QUINONE; Subject Term: OXIDOREDUCTASES; Subject Term: SEMIMETALS; Subject Term: ENZYMES; Subject Term: NATIVE element minerals; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 12p; Illustrations: 6 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M604120200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gehring, Theresa A.
AU - Griffin, Bill
AU - Williams, Rod
AU - Geiseker, Charles
AU - Rushing, Larry G.
AU - Siitonen, Paul H.
T1 - Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/08/18/
VL - 840
IS - 2
M3 - Article
SP - 132
EP - 138
SN - 15700232
AB - Abstract: A liquid chromatographic (LC) method for determining 14 sulfonamide (SA) (sulfanilamide, sulfadiazine (SDZ), sulfathiazole, sulfapyridine, sulfamerazine (SMR), sulfamethazine (SMZ), sulfamethizole, sulfamethoxypyridazine, sulfachloropyridazine (SCP), sulfamonomethoxine, sulfadoxine, sulfamethoxazole, sulfadimethoxine (SDM), and sulfaquinoxaline (SQX)) residues in edible catfish, shrimp and salmon tissues was developed and validated at 5, 10 or 20ngg−1. The method was then used to determine residues in tissues of catfish, shrimp and salmon dosed with six selected sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine, sulfachloropyridazine, sulfadimethoxine and sulfaquinoxaline). All assays were within U.S. Food and Drug Administration guidelines for recovery and intra-assay variability. The method was developed to determine possible sulfonamide residues in aquacultured catfish, shrimp and salmon produced for food. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SULFONAMIDES
KW - LIQUID chromatography
KW - DERIVATIZATION
KW - FLUORESCENCE
KW - CATFISHES
KW - SHRIMPS
KW - SALMON
KW - Catfish
KW - Liquid chromatography
KW - Salmon
KW - Shrimp
KW - Sulfonamides
N1 - Accession Number: 21828841; Gehring, Theresa A. 1; Email Address: Tgehring@nctr.fda.gov Griffin, Bill 2 Williams, Rod 3 Geiseker, Charles 4 Rushing, Larry G. 1 Siitonen, Paul H. 1; Affiliation: 1: Division of Biochemical Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Stuttgart National Aquaculture Research Center, U.S. Department of Agriculture, Stuttgart, AR 72160, USA 3: University of Arizona, Tucson, AZ 85721, USA 4: U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708, USA; Source Info: Aug2006, Vol. 840 Issue 2, p132; Subject Term: SULFONAMIDES; Subject Term: LIQUID chromatography; Subject Term: DERIVATIZATION; Subject Term: FLUORESCENCE; Subject Term: CATFISHES; Subject Term: SHRIMPS; Subject Term: SALMON; Author-Supplied Keyword: Catfish; Author-Supplied Keyword: Liquid chromatography; Author-Supplied Keyword: Salmon; Author-Supplied Keyword: Shrimp; Author-Supplied Keyword: Sulfonamides; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.04.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roscoe, R. J.
AU - Graydon, J. R.
T1 - Adult Blood Lead Epidemiology and Surveillance -- United States, 2003-2004.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2006/08/18/
VL - 55
IS - 32
M3 - Article
SP - 876
EP - 879
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - This report summarizes the data collected by the U.S. Centers for Disease Control and Prevention under its Adult Blood Lead Epidemiology and Surveillance (ABLES) program from 2003 to 2004. It compares them with annual data collected since 1994. The findings indicated that the national rate of adults with elevated blood lead levels (BLLs) declined from 2002 to 2003 and declined further in 2004. Projections using 1994-2004 ABLES data trends indicate the national prevalence rate of adults with elevated BLLs.
KW - LEAD in the body
KW - METALS in the body
KW - PUBLIC health -- United States
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 22034573; Roscoe, R. J. 1 Graydon, J. R. 1; Affiliation: 1: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 8/18/2006, Vol. 55 Issue 32, p876; Subject Term: LEAD in the body; Subject Term: METALS in the body; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lisowska, Katarzyna
AU - Długoński, Jerzy
AU - Freeman, James P.
AU - Cerniglia, Carl E.
T1 - The effect of the corticosteroid hormone cortexolone on the metabolites produced during phenanthrene biotransformation in Cunninghamella elegans
JO - Chemosphere
JF - Chemosphere
Y1 - 2006/08/22/
VL - 64
IS - 9
M3 - Article
SP - 1499
EP - 1506
SN - 00456535
AB - Abstract: The metabolism of phenanthrene and the mammalian corticosteroid hormone cortexolone by the fungus Cunninghamella elegans was studied. The amounts of the cortexolone transformation products, cortisol and epicortisol, were affected by the presence of phenanthrene. Approximately 40% more cortisol was produced by C. elegans in cultures with phenanthrene. In contrast, epicortisol formation decreased. C. elegans transformed phenanthrene to phenanthrene trans-1,2-,3,4-, and 9,10-dihydrodiols, phenols, diphenols (diols) and glucoside conjugates of 1-, 2-, 3-, 4-, and 9-phenanthrols. Almost all of the phenanthrene initially added was metabolized to ethyl acetate extractable metabolites. In the mycelia and culture medium extracts, phenanthrol glucosides represented 80% and 94% of the total metabolites, respectively. The major metabolite was the glucoside conjugate of 1-phenanthrol. The presence of cortexolone affected the biodegradation of phenanthrene by decreasing the amounts of phenanthrene metabolites compared to control cultures. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADRENOCORTICAL hormones
KW - METABOLITES
KW - CHEMICAL ecology
KW - BIOCHEMISTRY
KW - Corticosteroids
KW - Cunninghamella elegans
KW - Glucoside conjugates
KW - Metabolism
KW - Phenanthrene
N1 - Accession Number: 21751899; Lisowska, Katarzyna 1; Email Address: katalis@biol.uni.lodz.pl Długoński, Jerzy 1 Freeman, James P. 2 Cerniglia, Carl E. 3; Affiliation: 1: Department of Industrial Microbiology and Biotechnology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA 3: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA; Source Info: Aug2006, Vol. 64 Issue 9, p1499; Subject Term: ADRENOCORTICAL hormones; Subject Term: METABOLITES; Subject Term: CHEMICAL ecology; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Corticosteroids; Author-Supplied Keyword: Cunninghamella elegans; Author-Supplied Keyword: Glucoside conjugates; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Phenanthrene; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.chemosphere.2005.12.066
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - Woodruff, Jeffrey T.
T1 - Use of liquid chromatography–mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a “natural” herbal dietary supplement
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/08/25/
VL - 1125
IS - 1
M3 - Article
SP - 67
EP - 75
SN - 00219673
AB - Abstract: An herbal dietary supplement, marketed as a natural product for the enhancement of sexual function, was purchased covertly over the internet. The product was analyzed by LC–MS and found to contain a compound related to synthetic phosphodiesterase 5 (PDE-5) inhibitors. Based on LC with photodiode array and mass spectral detection, along with collision-induced dissociation-mass spectral analysis, the structure of the compound was tentatively identified as a designer drug of vardenafil in which the N-ethylpiperazine ring had been replaced by a piperidine ring. This structure was unambiguously confirmed by acid hydrolysis of both the unknown (“piperidenafil”) and vardenafil and comparison of their hydrolysis products by LC–MS and GC–MS. The hydrolytic technique proved to be a useful tool for the structure elucidation of piperidenafil and may be a useful technique for the structure elucidation of other erectile dysfunction designer drugs in the future. The dosage level of piperidenafil in the herbal product was 41mg per capsule when calculated as the free base. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Liquid chromatography
KW - Dietary supplements
KW - Synthetic drugs
KW - Herbal medicine
KW - Designer drug
KW - Dietary supplement
KW - Erectile dysfunction
KW - Herbal
KW - Phosphodiesterase-5 inhibitor
KW - Piperidenafil
KW - Vardenafil
N1 - Accession Number: 21828441; Reepmeyer, John C.; Email Address: reepmeyerj@cder.fda.gov; Woodruff, Jeffrey T. 1; Affiliations: 1: US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA; Issue Info: Aug2006, Vol. 1125 Issue 1, p67; Thesaurus Term: Liquid chromatography; Thesaurus Term: Dietary supplements; Subject Term: Synthetic drugs; Subject Term: Herbal medicine; Author-Supplied Keyword: Designer drug; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: Erectile dysfunction; Author-Supplied Keyword: Herbal; Author-Supplied Keyword: Phosphodiesterase-5 inhibitor; Author-Supplied Keyword: Piperidenafil; Author-Supplied Keyword: Vardenafil; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2006.05.018
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - de Jager, Lowri S.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Analysis of ginkgolides and bilobalide in food products using LC–APCI–MS
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2006/08/28/
VL - 41
IS - 5
M3 - Article
SP - 1552
EP - 1559
SN - 07317085
AB - Abstract: A method was developed for the extraction and quantification of five marker compounds characteristic of Ginkgo biloba. Five ginkgo terpene trilactones: bilobalide and ginkgolides A, B, C, and J, were selected as marker compounds for this study. Initial studies produced a simple methanol extraction method for determination of gingko markers in solid dietary supplements. Five dietary supplements were analyzed and the results were later compared to the concentrations detected in the analysis of beverages. Beverage samples were prepared by extracting the ginkgo terpene trilactones using an optimized solid phase extraction (SPE) method. The extracts were analyzed using LC–atmospheric pressure chemical ionization (APCI)–MS in the negative ionization mode. The limits of detection of the extraction method ranged from 6.8 to 3.2ngmL−1. Using the optimized method, 14 drinks and 3 tea products were analyzed. Concentrations of total marker compounds in drinks ranged between 1685 and 21.4ngmL−1 with individual ginkgo terpene trilactones being detected at ppb concentrations. Analysis of brewed tea products presented much higher total marker compound concentrations ranging from 8.12 and 16.6μgmL−1. Analytical results reproducibility data, and recovery of the SPE method are presented. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINKGO
KW - FOOD
KW - VITAMINS
KW - DIETARY supplements
KW - Bilobalide
KW - Food analysis
KW - Ginkgo
KW - Ginkgo biloba
KW - Ginkgolide
KW - LC–MS
N1 - Accession Number: 22132580; de Jager, Lowri S.; Email Address: ldejager@cfsan.fda.gov Perfetti, Gracia A. 1 Diachenko, Gregory W. 1; Affiliation: 1: U.S. Food and Drug Administration, Centre for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD, USA; Source Info: Aug2006, Vol. 41 Issue 5, p1552; Subject Term: GINKGO; Subject Term: FOOD; Subject Term: VITAMINS; Subject Term: DIETARY supplements; Author-Supplied Keyword: Bilobalide; Author-Supplied Keyword: Food analysis; Author-Supplied Keyword: Ginkgo; Author-Supplied Keyword: Ginkgo biloba; Author-Supplied Keyword: Ginkgolide; Author-Supplied Keyword: LC–MS; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jpba.2005.11.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Venable, R. M.
AU - Skibinsky, A.
AU - Pastor, R. W.
T1 - Constant surface tension molecular dynamics simulations of lipid bilayers with trehalose.
JO - Molecular Simulation
JF - Molecular Simulation
Y1 - 2006/08/30/
VL - 32
IS - 10/11
M3 - Article
SP - 849
EP - 855
SN - 08927022
AB - Surface areas and fluctuations evaluated from 50 ns molecular dynamics simulations of fully hydrated dipalmitoylphosphatidylcholine (DPPC) bilayers in a 1:2 trehalose:lipid ratio carried out at surface tensions 10, 17 and 25 dyn/cm/leaflet are compared with those of pure bilayers under the same conditions. Trehalose increases the surface area, as consistent with the surface tension lowering observed in simulations at constant area. The system bulk elastic modulus Kb = 1.5 ± 0.3 × 1010 dyn/cm2. It is independent of bilayer surface area and trehalose content within statistical error. In contrast, the area elastic modulus Ka shows a strong area dependence. At 64 Å2/lipid (the experimental surface area), Ka = 138 ± 26 dyn/cm for a pure DPPC bilayer and 82 ± 10 dyn/cm for one with trehalose; i.e. trehalose increases fluidity of the bilayer surface at this area per lipid. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Simulation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURFACE tension
KW - MOLECULAR dynamics
KW - SURFACE area
KW - BILAYER lipid membranes
KW - MYCOSES
KW - COMPRESSIBILITY
KW - ELASTICITY
KW - Area compressibility modulus
KW - Bulk compressibility modulus
KW - DPPC
KW - Equivalence of ensembles
KW - Isotherm
N1 - Accession Number: 22909698; Venable, R. M. 1 Skibinsky, A. 1 Pastor, R. W. 1; Email Address: richard.pastor@fda.hhs.gov; Affiliation: 1: Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD, 20852-1448, USA; Source Info: Aug2006, Vol. 32 Issue 10/11, p849; Subject Term: SURFACE tension; Subject Term: MOLECULAR dynamics; Subject Term: SURFACE area; Subject Term: BILAYER lipid membranes; Subject Term: MYCOSES; Subject Term: COMPRESSIBILITY; Subject Term: ELASTICITY; Author-Supplied Keyword: Area compressibility modulus; Author-Supplied Keyword: Bulk compressibility modulus; Author-Supplied Keyword: DPPC; Author-Supplied Keyword: Equivalence of ensembles; Author-Supplied Keyword: Isotherm; Number of Pages: 7p; Illustrations: 2 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/08927020600615018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106283173
T1 - The intensive care unit, patient safety, and the Agency for Healthcare Research and Quality.
AU - Clancy CM
Y1 - 2006/09//Sep/Oct2006
N1 - Accession Number: 106283173. Language: English. Entry Date: 20070511. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9300756.
KW - Intensive Care Units
KW - Safety
KW - United States Agency for Healthcare Research and Quality
KW - Quality Assurance
KW - Sleep Deprivation
KW - Treatment Errors -- Prevention and Control
KW - United States
SP - 348
EP - 351
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 21
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Director of the Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 16973953.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kramer, B. Josea
AU - Wang, Mingming
AU - Hoang, Tuyen
AU - Harker, Judith O.
AU - Finke, Bruce
AU - Saliba, Debra
T1 - Identification of American Indian and Alaska Native Veterans in Administrative Data of the Veterans Health Administration and the Indian Health Service.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/09//
VL - 96
IS - 9
M3 - Article
SP - 1577
EP - 1578
PB - American Public Health Association
SN - 00900036
AB - We sought to determine the extent to which the Indian Health Service (IHS) identified enrollees who also use the Veterans Health Administration (VHA) as veterans. We used a bivariate analysis of administrative data from fiscal years 20022003 to study the target population. Of the 32 259 IHS enrollees who received care as veterans in the VHA, only 44% were identified by IHS as veterans. IHS data underestimates the number of veterans, and both IHS and VHA need mechanisms to recognize mutual beneficiaries in order to facilitate better coordination of strategic planning and resource sharing among federal health care agencies. (Am J Public Health. 2006;96:1577-1578.doi:10.2105/AJPH. 2005.073205) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERANS -- Health
KW - NATIVE Americans -- Health
KW - MEDICAL policy
KW - HEALTH planning -- Government policy
KW - HEALTH facilities -- Administration
KW - PUBLIC health administration
KW - ALASKA Native veterans
KW - MEDICAL care -- Evaluation
KW - UNITED States
KW - UNITED States. Veterans Health Administration
KW - UNITED States. Indian Health Service
N1 - Accession Number: 22304255; Kramer, B. Josea 1; Email Address: josea.kramer@va.gov Wang, Mingming 2 Hoang, Tuyen 2 Harker, Judith O. 3 Finke, Bruce 4 Saliba, Debra 3,5; Affiliation: 1: Department of Veterans Affairs (VA) Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, and the David Geffen School of Medicine, University of California, Los Angeles 2: VA Greater Los Angeles Healthcare System, Center for the Study of Healthcare Provider Behavior, Los Angeles 3: VA Greater Los Angeles Healthcare System, Geriatric Research Education and Clinical Center, Los Angeles 4: Indian Health Service, Elder Care Initiative, Northampton, Mass. 5: Center for the Study of Healthcare Provider Behavior, the David Geffen School of Medicine, University of California, Los Angeles, and the RAND Corporation, Los Angeles; Source Info: Sep2006, Vol. 96 Issue 9, p1577; Subject Term: VETERANS -- Health; Subject Term: NATIVE Americans -- Health; Subject Term: MEDICAL policy; Subject Term: HEALTH planning -- Government policy; Subject Term: HEALTH facilities -- Administration; Subject Term: PUBLIC health administration; Subject Term: ALASKA Native veterans; Subject Term: MEDICAL care -- Evaluation; Subject Term: UNITED States; Company/Entity: UNITED States. Veterans Health Administration Company/Entity: UNITED States. Indian Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article; Full Text Word Count: 1770
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ye, Hongping
T1 - Simultaneous determination of protein aggregation, degradation, and absolute molecular weight by size exclusion chromatography–multiangle laser light scattering
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2006/09//
VL - 356
IS - 1
M3 - Article
SP - 76
EP - 85
SN - 00032697
AB - Abstract: The feasibility of size exclusion chromotography (SEC)–multiangle laser-light scattering as a technique to investigate aggregation and degradation of glycosylated and nonglycosylated proteins, and antibodies under various conditions such as addition of detergent, changes in pH, and variation of protein concentration and heat stress temperature was examined. Separation of proteins and their aggregates was performed using SEC–high-performance liquid chromatography. Detection of analytes was carried out with on-line UV, refractive index, and multiangle laser light-scattering detectors. Quantification and molecular weight determination were performed using commercial software. Aggregation and degradation were examined under various conditions and quantitative results are presented for bovine serum albumin, choriogonadotropin, glyceraldehyde-3-phosphate dehydrogenase, Herceptin, and ReoPro. This method can simultaneously determine both the quantities and the molecular weights of macromolecules from a single injection. The determination of molecular weight is absolute which avoids misleading results caused by molecular shape or interactions with the column matrix. This technique is valuable not only for assessing the extent of aggregation but also for effectively monitoring molecule degradation as evidenced by molecular weight reduction and change in monomer amount. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - GEL permeation chromatography
KW - SERUM
KW - CHROMATOGRAPHIC analysis
KW - Absolute molecular weight
KW - Glycoproteins
KW - Pharmaceutical proteins
KW - Protein aggregation
KW - Protein degradation
KW - SEC-MALLS
N1 - Accession Number: 22008693; Ye, Hongping 1; Email Address: yeh@cder.fda.gov; Affiliation: 1: Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA; Source Info: Sep2006, Vol. 356 Issue 1, p76; Subject Term: PROTEINS; Subject Term: GEL permeation chromatography; Subject Term: SERUM; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Absolute molecular weight; Author-Supplied Keyword: Glycoproteins; Author-Supplied Keyword: Pharmaceutical proteins; Author-Supplied Keyword: Protein aggregation; Author-Supplied Keyword: Protein degradation; Author-Supplied Keyword: SEC-MALLS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ab.2006.05.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leiss, Jack k.
AU - Ratcliffe, Jennifer M.
AU - Lyden, Jennifer T.
AU - Sousa, Sara
AU - Orelien, Jean G.
AU - Boal, Winifred L.
AU - Jagger, Janine
T1 - Blood Exposure Among Paramedics: Incidence Rates From the National Study to Prevent Blood Exposure in Paramedics
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2006/09//
VL - 16
IS - 9
M3 - Article
SP - 720
EP - 725
SN - 10472797
AB - Purpose: The aim of the study is to estimate incidence rates of occupational blood exposure by route of exposure (needlesticks; cuts from sharp objects; mucous membrane exposures to the eyes, nose, or mouth; bites; and blood contact with nonintact skin) in US and California paramedics. Methods: A mail survey was conducted in a national probability sample of certified paramedics. Results: Proportions of paramedics who reported an exposure in the previous year were 21.6% (95% confidence interval [CI], 17.8–25.3) for the national sample and 14.8% (95% CI, 12.2–17.4) for California. The overall incidence rate was 6.0/10,000 calls (95% CI, 3.9–8.1). These rates represent more than 49,000 total exposures and more than 10,000 needlesticks per year among paramedics in the United States. Rates for mucocutaneous exposures and needlesticks were similar (∼1.2/10,000 calls). Rates for California were one third to one half the national rates. Sensitivity analysis showed that potential response bias would have little impact on the policy and intervention implications of the findings. Conclusion: Paramedics continue to be at substantial risk for blood exposure. More attention should be given to reducing mucocutaneous exposures. The impact of legislation on reducing exposures and the importance of nonintact skin exposures need to be better understood. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLIED health personnel
KW - VIRAL hepatitis
KW - BIOLOGICAL membranes
KW - HEPATITIS C
KW - Blood Exposure
KW - confidence interval ( CI )
KW - hepatitis B virus ( HBV )
KW - hepatitis C virus ( HCV )
KW - human immunodeficiency virus ( HIV )
KW - Incidence
KW - Needlestick
KW - Occupational Exposure
KW - Paramedic
KW - Prehospital
KW - Survey
N1 - Accession Number: 21920233; Leiss, Jack k. 1 Ratcliffe, Jennifer M. 1 Lyden, Jennifer T.; Email Address: Jlyden@constellagroup.com Sousa, Sara 1 Orelien, Jean G. 1 Boal, Winifred L. 1 Jagger, Janine 1; Affiliation: 1: From Constella Health Sciences, Durham, NC (J.K.L., J.M.R., J.T.L., S.S., J.G.O.); Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH (W.L.B.); and Department of Internal Medicine, University of Virginia, Charlottesville, VA (J.J.); Source Info: Sep2006, Vol. 16 Issue 9, p720; Subject Term: ALLIED health personnel; Subject Term: VIRAL hepatitis; Subject Term: BIOLOGICAL membranes; Subject Term: HEPATITIS C; Author-Supplied Keyword: Blood Exposure; Author-Supplied Keyword: confidence interval ( CI ); Author-Supplied Keyword: hepatitis B virus ( HBV ); Author-Supplied Keyword: hepatitis C virus ( HCV ); Author-Supplied Keyword: human immunodeficiency virus ( HIV ); Author-Supplied Keyword: Incidence; Author-Supplied Keyword: Needlestick; Author-Supplied Keyword: Occupational Exposure; Author-Supplied Keyword: Paramedic; Author-Supplied Keyword: Prehospital; Author-Supplied Keyword: Survey; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.annepidem.2005.12.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BINIENDA, ZBIGNIEW K.
AU - PRZYBYLA, BEATA D.
AU - ROBINSON, BONNIE L.
AU - SALEM, NADIA
AU - VIRMANI, ASHRAF
AU - AMATO, ANTONINO
AU - ALI, SYED F.
T1 - Effects of L-Carnitine Pretreatment in Methamphetamine and 3-Nitropropionic Acid-Induced Neurotoxicity.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 74
EP - 83
SN - 00778923
AB - Adult, male Sprague-Dawley rats were injected with 3-ni-tropropionic acid (3-NPA) at 30 mg/kg or methamphetamine (METH) at 20 mg/kg alone or following pretreatment with L-cartnitine (LC) at 100 mg/kg. Rectal temperature was measured before and 4 h following treatment. Animals were sacrificed at 4 h posttreatment. Monoamine neurotransmitters, dopamine (DA) and serotonin (5-HT), and their metabolites were analyzed in the striatum using high-performance liquid chromatography method coupled with electrochemical detection (HPLC/ED) . Transcripts of several genes related to DA metabolism were quantified using real time reverse transciption polymerase chain reaction (RT-PCR). Core temperature decreased significantly after 3-NPA acid and increased in METH-treated rats ( P < 0.05). Temperature change at 4 h exhibited a significant LC effect for 3-NPA, preventing hypothermia ( P < 0.05) and no effect for METH. Concentration of DA and 5-HT, and their metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), increased significantly in 3-NPA and decreased in METH-treated rats. An increase in DOPAC/DA turnover and serotonin observed after 3-NPA was abolished in LC-/3-NPA-treated rats. In both 3-NPA- and METH-treated rats, LC prevented an increase in DA receptor D1 gene expression. It appears that carnitine effect preventing hypothermia after 3-NPA treatments may be related not only to its mitochondriotropic actions but also to inhibitory effect on the DA and 5-HT systems activated after the exposure to 3-NPA. The same effect observed at the transcriptional level, at least for the DA receptor D1, may account for protection against METH toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHAMPHETAMINE
KW - CARNITINE
KW - MITOCHONDRIA
KW - DOPAMINE
KW - ANIMAL models in research
KW - THERAPEUTIC use
KW - 3-nitropropionic acid
KW - carnitine
KW - methamphetamine
KW - mitochondria
KW - neuroprotection
KW - striatum
N1 - Accession Number: 22419674; BINIENDA, ZBIGNIEW K. 1; Email Address: zbinienda@nctr.fda.gov PRZYBYLA, BEATA D. 1 ROBINSON, BONNIE L. 1 SALEM, NADIA 2 VIRMANI, ASHRAF 3 AMATO, ANTONINO 2 ALI, SYED F. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA 2: Sigma-tau Research, Inc., Gaithersburg, Maryland 20877, USA 3: Research and Development, Sigma-tau HealthScience, Pomezia 00040, Italy; Source Info: 2006, Vol. 1074 Issue 1, p74; Subject Term: METHAMPHETAMINE; Subject Term: CARNITINE; Subject Term: MITOCHONDRIA; Subject Term: DOPAMINE; Subject Term: ANIMAL models in research; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: 3-nitropropionic acid; Author-Supplied Keyword: carnitine; Author-Supplied Keyword: methamphetamine; Author-Supplied Keyword: mitochondria; Author-Supplied Keyword: neuroprotection; Author-Supplied Keyword: striatum; Number of Pages: 10p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1196/annals.1369.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SHARMA, HARI SHANKER
AU - ALI, SYED F.
T1 - Alterations in Blood–Brain Barrier Function by Morphine and Methamphetamine.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 198
EP - 224
SN - 00778923
AB - The possibility that stress associated with morphine and amphetamine administration or withdrawal will influence the blood–brain barrier (BBB) and brain dysfunction was examined in a rodent model. Repeated daily administration of morphine (10 mg/kg, i.p.) resulted in drug dependence in rats on the sixth day and onwards. Measurement of the BBB permeability to large molecule tracers normally bound to proteins, e.g., Evans blue albumin and radioiodine ([131]Iodine) did not show any leakage on the 12th day of drug dependence. On the other hand, spontaneous withdrawal of morphine on day 1 resulted in profound stress symptoms. These symptoms were much more intense on the second day of morphine withdrawal. Alterations in the BBB to protein tracers were seen in several regions of the brain. This increase in BBB to protein tracers was most pronounced on the second day of morphine withdrawal. These rats also exhibited abnormal neuronal, glial and stress protein, the heat-shock protein 72 kD (HSP-72 kD) response. On the other hand, acute administration of methamphetamine (40 mg/kg, i.p.) in mice resulted in marked extravasation of endogenous serum protein as seen with increased expression of albumin immunohistochemistry. These observations suggest that psychostimulants and associated stress are capable to influence the brain function, probably through modifying the BBB function, not reported earlier. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORPHINE
KW - METHAMPHETAMINE
KW - RATS
KW - BLOOD-brain barrier
KW - HEAT shock proteins
KW - blood–brain barrier
KW - blood-brain barrier
KW - brain dysfunction
KW - Evans blue
KW - glial cells
KW - heat shock protein
KW - methamphetamine
KW - mice
KW - morphine
KW - nerve cells
KW - radioiodine
KW - rats
KW - stress
N1 - Accession Number: 22419660; SHARMA, HARI SHANKER 1,2; Email Address: Sharma@surgsci.uu.se ALI, SYED F. 1; Affiliation: 1: Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, University Hospital, Uppsala University, SE-75185 Uppsala, Sweden 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA; Source Info: 2006, Vol. 1074 Issue 1, p198; Subject Term: MORPHINE; Subject Term: METHAMPHETAMINE; Subject Term: RATS; Subject Term: BLOOD-brain barrier; Subject Term: HEAT shock proteins; Author-Supplied Keyword: blood–brain barrier; Author-Supplied Keyword: blood-brain barrier; Author-Supplied Keyword: brain dysfunction; Author-Supplied Keyword: Evans blue; Author-Supplied Keyword: glial cells; Author-Supplied Keyword: heat shock protein; Author-Supplied Keyword: methamphetamine; Author-Supplied Keyword: mice; Author-Supplied Keyword: morphine; Author-Supplied Keyword: nerve cells; Author-Supplied Keyword: radioiodine; Author-Supplied Keyword: rats; Author-Supplied Keyword: stress; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 27p; Illustrations: 1 Black and White Photograph, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1196/annals.1369.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KANTHASAMY, ARTHI
AU - ANANTHARAM, V.
AU - ALI, SYED F.
AU - KANTHASAMY, A.G.
T1 - Methamphetamine Induces Autophagy and Apoptosis in a Mesencephalic Dopaminergic Neuronal Culture Model.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 234
EP - 244
SN - 00778923
AB - Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-induced oxidative damage in dopaminergic neuronal systems remains unclear. The goals of the present article were twofold: ( a) to develop an in vitro dopaminergic cell culture model to study cellular and molecular mechanisms underlying METH-ind-uced autophagy and apoptosis, and ( b) to determine whether lysosomal protease cathepsin-D activation, resulting from the loss of lysosomal membrane integrity, contributes to METH-induced apoptosis. To accomplish these goals, we characterized morphological and biochemical changes in an immortalized mesencephalic dopaminergic neuronal cell line (N27 cells) following treatment with METH. Exposure of METH (2 mM) to N27 cells resulted in the appearance of cytoplasmic vacuolar structures reminiscent of autophagic vacuoles within 3 h. In order to ascertain the identity of the vacuolar structures that are formed following METH exposure, immunohistochemical staining for markers of autophagy were performed. LAMP 2, a classical marker of autophagolysosomes, revealed an extensive punctuate pattern of distribution on the vacuolar membrane surface, with exclusive localization in the cytoplasm. Additionally, using DNA fragmentation analysis we showed a dose-dependent increase in fragmented DNA in METH treated N27 cells. Since METH-induced autophagy preceded DNA fragmentation, we tested whether dysfunction of the autophagolysosomal system contributes to nuclear damage. Immunofluorescence studies with cathepsin-d demonstrated a granular pattern of staining in untreated cells, whereas an increased cathepsin- D immunoreactivity with a globular pattern of staining was observed in METH-treated cells. Nevertheless, blockade of cathepsin-D activation by pepstatin-A, cathepsin-D inhibitor, failed to alter METH-induced DNA fragmentation. Collectively, these results demonstrate that N27 dopaminergic neuronal cell model may serve as an excellent in vitro model to study the mechanisms of METH-induced autophagy and apoptosis. Furthermore, it is less likely that cathepsin-D may serve as a trigger for the induction of apoptosis subsequent to exposure of N27 dopaminergic neuronal cells to METH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHAMPHETAMINE
KW - NEUROTOXICOLOGY
KW - DNA
KW - CELL organelles
KW - APOPTOSIS
KW - autophagy
KW - cathepsin-D
KW - DNA fragmentation
KW - methamphetamine
KW - neurotoxicity
N1 - Accession Number: 22419658; KANTHASAMY, ARTHI 1; Email Address: arthik@iastate.edu ANANTHARAM, V. 1 ALI, SYED F. 2 KANTHASAMY, A.G. 1; Affiliation: 1: Parkinson Disorders Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011-1250, USA 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, Arkansas 72079, USA; Source Info: 2006, Vol. 1074 Issue 1, p234; Subject Term: METHAMPHETAMINE; Subject Term: NEUROTOXICOLOGY; Subject Term: DNA; Subject Term: CELL organelles; Subject Term: APOPTOSIS; Author-Supplied Keyword: autophagy; Author-Supplied Keyword: cathepsin-D; Author-Supplied Keyword: DNA fragmentation; Author-Supplied Keyword: methamphetamine; Author-Supplied Keyword: neurotoxicity; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 2 Graphs; Document Type: Article
L3 - 10.1196/annals.1369.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22419658&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - VIRMANI, ASHRAF
AU - BINIENDA, ZBIGNIEW
AU - ALI, SYED
AU - GAETANI, FRANCO
T1 - Links between Nutrition, Drug Abuse, and the Metabolic Syndrome.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 303
EP - 314
SN - 00778923
AB - Nutritional deficiency in combination with drug abuse may increase risk of developing the metabolic syndrome by augmenting cell damage, excitotoxicity, reducing energy production, and lowering the antioxidant potential of the cells. We have reviewed here the following points: effects of drugs of abuse on nutrition and brain metabolism; effects of nutrition on actions of the drugs of abuse; drug abuse and probability of developing metabolic syndrome; role of genetic vulnerability in nutrition/drug abuse and brain damage; and the role of neuroprotective supplements in drug abuse. Nutrition education is an essential component of substance abuse treatment programs and can enhance substance abuse treatment outcomes. The strategies available, in particular the nutritional approach to protect the drug abusers from the metabolic syndrome and other diseases are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION
KW - DRUG abuse
KW - METABOLIC syndrome
KW - CREATINE
KW - COCAINE
KW - ECSTASY (Drug)
KW - acetyl- l-carnitine
KW - acetyl-L-carnitine
KW - alcohol
KW - brain
KW - cocaine
KW - creatine
KW - diabetes
KW - drug abuse
KW - ecstasy
KW - free radicals
KW - glycolysis
KW - L-carnitine
KW - liver
KW - metabolic compensation
KW - metabolic compromise
KW - metabolic modifier
KW - metabolic syndrome
KW - methamphetamine
KW - minerals
KW - nutrition
KW - reactive oxygen species (ROS)
KW - selenium
KW - supplements
KW - thiamine
KW - vitamins
KW - zinc
N1 - Accession Number: 22419653; VIRMANI, ASHRAF 1; Email Address: ashraf.virmani@st-hs.it BINIENDA, ZBIGNIEW 2 ALI, SYED 3 GAETANI, FRANCO 1; Affiliation: 1: Research and Development, Sigma tau-HealthScience, Pomezia 00040, Italy 2: Neurophysiology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA; Source Info: 2006, Vol. 1074 Issue 1, p303; Subject Term: NUTRITION; Subject Term: DRUG abuse; Subject Term: METABOLIC syndrome; Subject Term: CREATINE; Subject Term: COCAINE; Subject Term: ECSTASY (Drug); Author-Supplied Keyword: acetyl- l-carnitine; Author-Supplied Keyword: acetyl-L-carnitine; Author-Supplied Keyword: alcohol; Author-Supplied Keyword: brain; Author-Supplied Keyword: cocaine; Author-Supplied Keyword: creatine; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: drug abuse; Author-Supplied Keyword: ecstasy; Author-Supplied Keyword: free radicals; Author-Supplied Keyword: glycolysis; Author-Supplied Keyword: L-carnitine; Author-Supplied Keyword: liver; Author-Supplied Keyword: metabolic compensation; Author-Supplied Keyword: metabolic compromise; Author-Supplied Keyword: metabolic modifier; Author-Supplied Keyword: metabolic syndrome; Author-Supplied Keyword: methamphetamine; Author-Supplied Keyword: minerals; Author-Supplied Keyword: nutrition; Author-Supplied Keyword: reactive oxygen species (ROS); Author-Supplied Keyword: selenium; Author-Supplied Keyword: supplements; Author-Supplied Keyword: thiamine; Author-Supplied Keyword: vitamins; Author-Supplied Keyword: zinc; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 12p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1196/annals.1369.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22419653&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SAMANTARAY, SUPRITI
AU - RAY, SWAPAN K.
AU - ALI, SYED F.
AU - BANIK, NAREN L.
T1 - Calpain Activation in Apoptosis of Motoneurons in Cell Culture Models of Experimental Parkinsonism.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 349
EP - 356
SN - 00778923
AB - Parkinson's disease (PD) is a movement disorder characterized by progressive degeneration of primarily the dopaminergic neurons in the substantia nigra (SN). The present study briefly describes our findings to support the hypothesis that there is a possibility of degeneration of spinal cord (SC) motoneurons in course of parkinsonism. In cell culture models of experimental parkinsonism, we examined the degeneration of ventral SC motoneuron cell line (VSC4.1) following exposure to two different toxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone. Our studies suggested calpain activation in the apoptosis of VSC4.1 motoneurons due to exposure to these parkinsonian toxins. Furthermore, our study showed the toxic effects of the dopaminergic toxin methamphetamine (METH) on VSC4.1 cells. The results strongly implicated a possible role for calpain in the mechanism of motoneuron apoptosis during parkinsonian degeneration, at large. Hence, we examined the neuroprotective efficacy of calpeptin, a specific inhibitor of calpain, in cell culture model of experimental parkinsonism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CELL death
KW - CALPAIN
KW - PARKINSON'S disease
KW - BRAIN diseases
KW - METHAMPHETAMINE
KW - METHYLPHENYLTETRAHYDROPYRIDINE
KW - apoptosis
KW - calpain
KW - METH
KW - motoneurons
KW - MPTP
KW - parkinsonism
KW - rotenone
KW - VSC4.1 cells
N1 - Accession Number: 22419647; SAMANTARAY, SUPRITI 1 RAY, SWAPAN K. 1 ALI, SYED F. 2 BANIK, NAREN L. 1; Email Address: baniknl@musc.edu; Affiliation: 1: Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research-FDA, Jefferson, Arkansas 72079, USA; Source Info: 2006, Vol. 1074 Issue 1, p349; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: CALPAIN; Subject Term: PARKINSON'S disease; Subject Term: BRAIN diseases; Subject Term: METHAMPHETAMINE; Subject Term: METHYLPHENYLTETRAHYDROPYRIDINE; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: calpain; Author-Supplied Keyword: METH; Author-Supplied Keyword: motoneurons; Author-Supplied Keyword: MPTP; Author-Supplied Keyword: parkinsonism; Author-Supplied Keyword: rotenone; Author-Supplied Keyword: VSC4.1 cells; Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1196/annals.1369.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22419647&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MEYER, JERROLD S.
AU - BREVARD, MATTHEW E.
AU - PIPER, BRIAN J.
AU - ALI, SYED F.
AU - FERRIS, CRAIG F.
T1 - Neural Effects of MDMA as Determined by Functional Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Awake Marmoset Monkeys.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 365
EP - 376
SN - 00778923
AB - We used functional magnetic resonance imaging (fMRI) to investigate the acute effects of a recreational dose (1 mg/kg p.o.) of 3,4-methylenedioxymethamphetamine (MDMA) on regional brain activity in awake, restrained marmoset monkeys. In a second study, magnetic resonance spectroscopy (MRS) and postmortem measurements of serotonin transporter (SERT) binding and serotonin (5-HT) concentrations were used to determine the neurotoxic effects of low (4 × 1 mg/kg p.o.) and high (4 × 10 mg/kg i.m.) doses of MDMA. Several brain areas were significantly activated by the low oral dose of MDMA, including the midbrain raphe nuclei, hippocampus, hypothalamus, amygdala, and the corticostriatal circuit composed of the dorsal thalamus, sensory motor cortex, and basal ganglia. MDMA activated the primary visual cortex under baseline conditions and also enhanced the visual cortical response to photic stimulation. The onset of brain activation correlated well with the rise in plasma MDMA concentrations measured in separate monkeys given the same drug treatment. In the second study, the ratio of N-acetylaspartate (NAA; a putative neuronal marker) to creatine was significantly reduced in the hypothalamus following either MDMA treatment regimen, suggesting a particular vulnerability of this structure to MDMA-induced damage. Monkeys given the high-dose regimen also showed prolonged hyperthermia and reductions in 5-HT and SERT in a number of brain areas. These results are the first to identify the pattern of MDMA-induced brain activation in a nonhuman primate model, and they further suggest that even recreational doses of MDMA may have adverse consequences as indicated by the reduced hypothalamic NAA/creatine ratio. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIC resonance imaging
KW - DIAGNOSTIC imaging
KW - ECSTASY (Drug)
KW - HALLUCINOGENIC drugs
KW - METHAMPHETAMINE
KW - VISUAL cortex
KW - SEROTONIN
KW - CALLITHRIX jacchus
KW - 3
KW - 3,4-methylenedioxymethamphetamine
KW - 4-methylenedioxymethamphetamine
KW - BOLD
KW - common marmoset
KW - magnetic resonance imaging
KW - magnetic resonance spectroscopy
KW - serotonin
KW - visual cortex
N1 - Accession Number: 22419645; MEYER, JERROLD S. 1,2; Email Address: jmeyer@psych.umass.edu BREVARD, MATTHEW E. 3 PIPER, BRIAN J. 2 ALI, SYED F. 4 FERRIS, CRAIG F. 3; Affiliation: 1: Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA 2: Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA 3: Center for Comparative Neuroimaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA 4: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA; Source Info: 2006, Vol. 1074 Issue 1, p365; Subject Term: MAGNETIC resonance imaging; Subject Term: DIAGNOSTIC imaging; Subject Term: ECSTASY (Drug); Subject Term: HALLUCINOGENIC drugs; Subject Term: METHAMPHETAMINE; Subject Term: VISUAL cortex; Subject Term: SEROTONIN; Subject Term: CALLITHRIX jacchus; Author-Supplied Keyword: 3; Author-Supplied Keyword: 3,4-methylenedioxymethamphetamine; Author-Supplied Keyword: 4-methylenedioxymethamphetamine; Author-Supplied Keyword: BOLD; Author-Supplied Keyword: common marmoset; Author-Supplied Keyword: magnetic resonance imaging; Author-Supplied Keyword: magnetic resonance spectroscopy; Author-Supplied Keyword: serotonin; Author-Supplied Keyword: visual cortex; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 12p; Illustrations: 1 Black and White Photograph, 1 Graph; Document Type: Article
L3 - 10.1196/annals.1369.036
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SHARMA, HARI S.
AU - LUNDSTEDT, TORBJÖRN
AU - BOMAN, ARNE
AU - LEK, PER
AU - SEIFERT, ELISABETH
AU - WIKLUND, LARS
AU - ALI, SYED F.
T1 - A Potent Serotonin-Modulating Compound AP-267 Attenuates Morphine Withdrawal-Induced Blood–Brain Barrier Dysfunction in Rats.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09//
VL - 1074
IS - 1
M3 - Article
SP - 482
EP - 496
SN - 00778923
AB - The possibility that a serotonin 5-HT2c receptor-modulating compound, AP-267, will influence spontaneous morphine withdrawal symptoms and the alterations in the brain fluid microenvironment was examined in a rat model. Daily administration of morphine (10 mg/kg, i.p.) for 10 days resulted in dependence of rats as seen by loss of analgesic response. On the 11th day, no morphine administration was given. This resulted in profound withdrawal symptoms 24 h after morphine withdrawal. The magnitude and severity of these symptoms were increased further 48 h after withdrawal. Measurement of the blood-brain barrier (BBB) permeability, a measure of perturbed brain fluid microenvironment showed leakage of Evans blue and radioiodine tracers in several parts of the brain in rats showing withdrawal symptoms. Whereas, rats treated with AP-267 either on the 1st day or 2nd day morphine withdrawal showed much less symptoms and leakage of the BBB. Taken together, these observations suggest that ( a) stress associated with the withdrawal symptoms are sufficient enough to induce breakdown of the BBB function, and ( b) modulation of serotonin 5-HT2c receptors may have some protective influence on the stress symptoms and the BBB disruption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MORPHINE
KW - PAIN management
KW - BRAIN -- Blood-vessels
KW - DRUG addiction
KW - DRUG abuse
KW - 5-HT2c receptor
KW - AP-267
KW - blood-brain barrier
KW - dependence
KW - Evans blue
KW - morphine
KW - radioiodine
KW - serotonin
KW - spontaneous withdrawal
KW - withdrawal symptoms
N1 - Accession Number: 22419632; SHARMA, HARI S. 1,2; Email Address: Sharma@surgsci.uu.se LUNDSTEDT, TORBJÖRN 3,4 BOMAN, ARNE 3 LEK, PER 3 SEIFERT, ELISABETH 3 WIKLUND, LARS 2 ALI, SYED F. 1; Affiliation: 1: Laboratory of Neurochemistry, Division of Neurotoxicology, National Center for Toxicology Research, Food and Drug Administration Laboratories, Jefferson 72079, Arkansas 2: Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, SE-75185 Uppsala, Sweden 3: Acure Pharma AB, Ulleråkersv. 38, SE-756 43 Uppsala, Sweden 4: Department of Organic and Pharmaceutical Chemistry, Uppsala University, SE-741 23 Uppsala, Sweden; Source Info: 2006, Vol. 1074 Issue 1, p482; Subject Term: MORPHINE; Subject Term: PAIN management; Subject Term: BRAIN -- Blood-vessels; Subject Term: DRUG addiction; Subject Term: DRUG abuse; Author-Supplied Keyword: 5-HT2c receptor; Author-Supplied Keyword: AP-267; Author-Supplied Keyword: blood-brain barrier; Author-Supplied Keyword: dependence; Author-Supplied Keyword: Evans blue; Author-Supplied Keyword: morphine; Author-Supplied Keyword: radioiodine; Author-Supplied Keyword: serotonin; Author-Supplied Keyword: spontaneous withdrawal; Author-Supplied Keyword: withdrawal symptoms; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 15p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1196/annals.1369.049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adjei, Michael D.
AU - Heinze, Thomas M.
AU - Deck, Joanna
AU - Freeman, James P.
AU - Williams, Anna J.
AU - Sutherland, John B.
T1 - Transformation of the Antibacterial Agent Norfloxacin by Environmental Mycobacteria.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/09//
VL - 72
IS - 9
M3 - Article
SP - 5790
EP - 5793
SN - 00992240
AB - Because fluoroquinolone antimicrobial agents may be released into the environment, the potential for environmental bacteria to biotransform these drugs was investigated. Eight Mycobacterium sp. cultures in a sorbitol-yeast extract medium were dosed with 100 μg ml-1 of norfloxacin and incubated for 7 days. The MICs of norfloxacin for these strains, tested by an agar dilution method, were 1.6 to 25 μg ml-1. Cultures were extracted with ethyl acetate, and potential metabolites in the extracts were purified by high-performance liquid chromatography. The metabolites were identified using mass spectrometry and nuclear magnetic resonance spectroscopy. N-Acetylnorfloxacin (5 to 50% of the total absorbance at 280 nm) was produced by the eight Mycobacterium strains. N-Nitrosonorfloxacin (5 to 30% of the total absorbance) was also produced by Mycobacterium sp. strain PYR100 and Mycobacterium gilvum PYR-GCK. The MICs of N-nitrosonorfloxacin and N-acetylnorfloxacin were 2- to 38- and 4- to 1,000-fold higher, respectively, than those of norfloxacin for several different bacteria, including the two strains that produced both metabolites. Although N-nitrosonorfloxacin had less antibacterial activity, nitrosamines are potentially carcinogenic. The biotransformation of fluoroquinolones by mycobacteria may serve as a resistance mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBACTERIAL agents
KW - NORFLOXACIN
KW - MYCOBACTERIA
KW - BIOTRANSFORMATION (Metabolism)
KW - METABOLITES
KW - CHROMATOGRAPHIC analysis
KW - MASS spectrometry
KW - BACTERIA
KW - CARCINOGENS
N1 - Accession Number: 22496680; Adjei, Michael D. 1,2 Heinze, Thomas M. 3 Deck, Joanna 1 Freeman, James P. 3 Williams, Anna J. 1 Sutherland, John B. 1; Email Address: john.sutherIand@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 2: Norfolk Department of Public Health, 830 Southampton Ave., Norfolk, VA 23510 3: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; Source Info: Sep2006, Vol. 72 Issue 9, p5790; Subject Term: ANTIBACTERIAL agents; Subject Term: NORFLOXACIN; Subject Term: MYCOBACTERIA; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: METABOLITES; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MASS spectrometry; Subject Term: BACTERIA; Subject Term: CARCINOGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.03032-05
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marszal, Ewa
AU - Shrake, Andrew
T1 - Serpin crystal structure and serpin polymer structure
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2006/09//
VL - 453
IS - 1
M3 - Article
SP - 121
EP - 127
SN - 00039861
AB - Abstract: Serpins are a family of structurally homologous proteins having metastable native structures. As a result, a serpin variant destabilized by mutation(s) has a tendency to undergo conformational changes leading to inactive forms, e.g., the latent form and polymer. Serpin polymers are involved in a number of conformational diseases. Although several models for polymer structure have been proposed, the actual structure remains unknown. Here, we provide a comprehensive list of serpins, both free and in complexes, deposited in the Protein Data Bank. Our discussion focuses on structures that potentially can contribute to a better understanding of polymer structure. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERPINS
KW - AMINO acids
KW - POLYMERS
KW - SERINE proteinases -- Inhibitors
KW - Conformational disease
KW - Serine protease inhibitor
KW - Serpin
KW - Serpin crystal structure
KW - Serpin polymer
N1 - Accession Number: 22075985; Marszal, Ewa; Email Address: ewa.marszal@fda.hhs.gov Shrake, Andrew 1; Affiliation: 1: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Sep2006, Vol. 453 Issue 1, p121; Subject Term: SERPINS; Subject Term: AMINO acids; Subject Term: POLYMERS; Subject Term: SERINE proteinases -- Inhibitors; Author-Supplied Keyword: Conformational disease; Author-Supplied Keyword: Serine protease inhibitor; Author-Supplied Keyword: Serpin; Author-Supplied Keyword: Serpin crystal structure; Author-Supplied Keyword: Serpin polymer; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.abb.2006.03.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, D. Rh.
AU - McCarroll, I.
AU - Roberts, R.
AU - Karunaratne, P.
AU - Roberts, C.
AU - Casey, D.
AU - Morgan, S.
AU - Touhig, K.
AU - Morgan, J.
AU - Collins, F.
AU - Hemingway, J.
T1 - Surveillance of insecticide resistance in head lice using biochemical and molecular methods.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2006/09//
VL - 91
IS - 9
M3 - Article
SP - 777
EP - 778
SN - 00039888
AB - Treatment of head louse infection is primarily through topical insecticides. However, there is growing evidence of resistance. A representative population sample was tested using biochemical and molecular methods; it was shown that, in Wales, treatments containing pyrethroids are likely to be less effective in controlling head louse infection than those containing organophosphates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LICE
KW - INSECTICIDE resistance
KW - PYRETHROIDS
KW - ORGANOPHOSPHORUS compounds
KW - PESTICIDES -- Physiological effect
KW - INSECTS
N1 - Accession Number: 22211223; Thomas, D. Rh. 1; Email Address: Daniel.Thomas@nphs.wales.nhs.uk McCarroll, I. 2 Roberts, R. 3 Karunaratne, P. 2 Roberts, C. 3 Casey, D. 3 Morgan, S. 4 Touhig, K. 5 Morgan, J. 2 Collins, F. Hemingway, J. 2; Affiliation: 1: National Public Health Service for Wales Communicable Disease Surveillance Centre, Cardiff, UK 2: Liverpool School of Tropical Medicine, Liverpool, UK 3: National Public Health Service for Wales Infection and Communicable Disease Service, North Wales Health Protection Team, Mold, Flintshire, UK 4: National Public Health Service for Wales Infection and Communicable Disease Mid and West Wales Health Protection Team, St Davids Hospital, Carmarthen, UK 5: National Public Health Service for Wales Infection and Communicable Disease Service South East Wales Health Protection Team, Temple of Peace & Health, Cardiff, UK; Source Info: Sep2006, Vol. 91 Issue 9, p777; Subject Term: LICE; Subject Term: INSECTICIDE resistance; Subject Term: PYRETHROIDS; Subject Term: ORGANOPHOSPHORUS compounds; Subject Term: PESTICIDES -- Physiological effect; Subject Term: INSECTS; Number of Pages: 2p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1136/adc.2005.091280
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22211223&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106246890
T1 - Surveillance of insecticide resistance in head lice using biochemical and molecular methods.
AU - Thomas DR
AU - McCarroll L
AU - Roberts R
AU - Karunaratne P
AU - Roberts C
AU - Casey D
AU - Morgan S
AU - Touhig K
AU - Morgan J
AU - Collins F
AU - Hemingway J
Y1 - 2006/09//
N1 - Accession Number: 106246890. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Funded in part by the Wales Office of R&D for Health and Social Care. NLM UID: 0372434.
KW - Drug Resistance
KW - Insecticides
KW - Lice -- Drug Effects
KW - Lice Infestations -- Drug Therapy
KW - Child
KW - Funding Source
KW - Random Sample
KW - Skin Diseases -- Drug Therapy
KW - Wales
KW - Human
SP - 777
EP - 778
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
JA - ARCH DIS CHILD
VL - 91
IS - 9
PB - BMJ Publishing Group
AB - Treatment of head louse infection is primarily through topical insecticides. However, there is growing evidence of resistance. A representative population sample was tested using biochemical and molecular methods; it was shown that, in Wales, treatments containing pyrethroids are likely to be less effective in controlling head louse infection than those containing organophosphates.
SN - 0003-9888
AD - National Public Health Service for Wales Communicable Disease Surveillance Centre, Cardiff, UK. Daniel.Thomas@nphs.wales.nhs.uk
U2 - PMID: 16774979.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jae-Ho Shin
AU - Hyun Ju Moon
AU - Tae Sung Kim
AU - Il Hyun Kang
AU - Ho Yeon Ki
AU - Kwang Sik Choi
AU - Soon Young Han
T1 - Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the “Enhanced OECD Test Guideline No. 407” to detect endocrine effects.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2006/09//
VL - 80
IS - 9
M3 - Article
SP - 547
EP - 554
SN - 03405761
AB - We performed a 28-day repeated-dose toxicity study of vinclozolin, a widely used fungicide, based on the draft protocol of the “Enhanced OECD Test Guideline 407” (Enhanced TG407) to investigate whether vinclozolin has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with vinclozolin daily by oral gavage at dose rates of 0, 3.125, 12.5, 50 and 200 mg/kg/day for at least 28 days. The vinclozolin-treated male rats showed a reduction of epididymis and accessory sex organ weights and an alteration of hormonal patterns. A slight prolongation of the estrous cycle and changes in the estrogen/testosterone ratio and luteinizing hormone level were observed in vinclozolin-treated female rats. Thyroxin concentrations were decreased and thyroid-stimulating hormone concentrations were increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of vinclozolin could be detected by the parameters examined in the present study based on the OECD protocol, suggesting the Enhanced TG407 protocol should be a suitable screening test for the detection of endocrine-mediated effects of chemicals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VINCLOZOLIN
KW - ORAL medication
KW - DRUGS -- Toxicology
KW - ENDOCRINE glands
KW - MEDICAL protocols
KW - Endocrine effects
KW - Enhanced OECD Test Guideline 407
KW - Rat
KW - Vinclozolin
N1 - Accession Number: 21870940; Jae-Ho Shin 1; Email Address: jaehoshin@hanmir.com Hyun Ju Moon 1 Tae Sung Kim 1 Il Hyun Kang 1 Ho Yeon Ki 1 Kwang Sik Choi 1 Soon Young Han 1; Affiliation: 1: Endocrine Toxicology Team, National Institute of Toxicological Research , Korea Food and Drug Administration , Seoul 122-704 Korea; Source Info: Sep2006, Vol. 80 Issue 9, p547; Subject Term: VINCLOZOLIN; Subject Term: ORAL medication; Subject Term: DRUGS -- Toxicology; Subject Term: ENDOCRINE glands; Subject Term: MEDICAL protocols; Author-Supplied Keyword: Endocrine effects; Author-Supplied Keyword: Enhanced OECD Test Guideline 407; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Vinclozolin; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1007/s00204-006-0080-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, H. H.
AU - Stark, C. J.
AU - Atreya, C. D.
T1 - The rubella virus nonstructural protease recognizes itself via an internal sequence present upstream of the cleavage site for trans-activity.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2006/09//
VL - 151
IS - 9
M3 - Article
SP - 1841
EP - 1851
SN - 03048608
AB - The substrate requirement for rubella virus protease trans-activity is unknown. Here, we analyzed the cleavability of RV P200-derived substrates varying in their N-terminal lengths (72-475 amino acids) from the cleavage site by the RV protease trans-activity. Only substrates with at least 309 amino acid residues N-terminal to the cleavage site were able to undergo cleavage. Further, rubella sequence was found to be necessary in the N-terminal region of the substrate, whereas a heterologous sequence C-terminal to the cleavage site was tolerated. These results demonstrated a requirement for residues located between amino acids 994-1102 of the RV P200 polyprotein, besides its cleavage site for RV protease trans-activity. This region overlaps with the starting site of the essential cis-protease activity of RV P200 polyprotein. This is a novel observation for a viral protease of the family Togaviridae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RUBELLA virus
KW - PROTEOLYTIC enzymes
KW - AMINO acids
KW - RNA viruses
KW - PLASMIDS
KW - PROTEINS
N1 - Accession Number: 21908903; Chen, H. H. 1 Stark, C. J. 1 Atreya, C. D. 1; Email Address: ATREYA@CBER.FDA.GOV; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, U.S.A.; Source Info: Sep2006, Vol. 151 Issue 9, p1841; Subject Term: RUBELLA virus; Subject Term: PROTEOLYTIC enzymes; Subject Term: AMINO acids; Subject Term: RNA viruses; Subject Term: PLASMIDS; Subject Term: PROTEINS; Number of Pages: 11p; Document Type: Article
L3 - 10.1007/s00705-006-0744-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thorpe, Susan J.
AU - Fox, Bernard
AU - Heath, Alan
AU - Behr-Gross, Marie-Emmanuelle
AU - Virata, Maria L.
AU - Yu, Mei-Ying W.
T1 - International collaborative study to assess candidate reference preparations to control the level of anti-D in IVIG for use in Europe and the United States
JO - Biologicals
JF - Biologicals
Y1 - 2006/09//
VL - 34
IS - 3
M3 - Article
SP - 209
EP - 212
SN - 10451056
AB - Abstract: Regulatory requirements to control the level of anti-D in intravenous immunoglobulin (IVIG) products with European and United States (US) licences are to be introduced. A reference preparation of IVIG containing anti-D at 0.0475 IU/ml and having a nominal titre of 8 using the proposed direct haemagglutination reference method was deemed suitable to define the anti-D limit. This preparation, code 02/228, and a negative control IVIG preparation, code 02/226, were established by the World Health Organization as International Reference Reagents (IRRs). As stocks of the IRRs are limited, new larger fill stocks of positive and negative reference preparations, codes 04/132 and 04/140, respectively, were produced. The results from an international collaborative study involving 16 laboratories showed that preparations 04/132 and 04/140 are indistinguishable from the corresponding IRRs 02/228 and 02/226, respectively, using the proposed direct haemagglutination reference method. Stocks of 04/132 and 04/140 have been shared with the European Directorate for the Quality of Medicines (re-coded as 23613 and 23614, respectively) and with the Center for Biologics Evaluation and Research of the United States Food and Drug Administration (re-coded as CBER Lots 1B and 1N-b, respectively) for use as European and US Biological Reference Preparations, respectively. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - LICENSED products
KW - WORLD health
KW - UNITED States
KW - Anti-Rho
KW - Haemagglutination
KW - Haemolysis
KW - IGIV
KW - Reference preparations
KW - Specification
N1 - Accession Number: 22012994; Thorpe, Susan J. 1; Email Address: sthorpe@nibsc.ac.uk Fox, Bernard 1 Heath, Alan 1 Behr-Gross, Marie-Emmanuelle 2 Virata, Maria L. 3 Yu, Mei-Ying W. 3; Affiliation: 1: National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK 2: European Directorate for the Quality of Medicines, Strasbourg, France 3: Center for Biologics Evaluation and Research of the United States Food and Drug Administration, Bethesda, MD, USA; Source Info: Sep2006, Vol. 34 Issue 3, p209; Subject Term: IMMUNOGLOBULINS; Subject Term: LICENSED products; Subject Term: WORLD health; Subject Term: UNITED States; Author-Supplied Keyword: Anti-Rho; Author-Supplied Keyword: Haemagglutination; Author-Supplied Keyword: Haemolysis; Author-Supplied Keyword: IGIV; Author-Supplied Keyword: Reference preparations; Author-Supplied Keyword: Specification; NAICS/Industry Codes: 533110 Lessors of Nonfinancial Intangible Assets (except Copyrighted Works); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.biologicals.2005.11.001
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Lott, J.P.
AU - Katz, K.A.
T1 - Pharmaceutical companies’ policies and practices regarding prospective registration of dermatology-related clinical trials.
JO - British Journal of Dermatology
JF - British Journal of Dermatology
Y1 - 2006/09//
VL - 155
IS - 3
M3 - Letter
SP - 635
EP - 638
PB - Wiley-Blackwell
SN - 00070963
AB - A letter to the editor related to pharmaceutical companies' policies and practices regarding prospective registration of dermatology-related clinical trials is presented.
KW - LETTERS to the editor
KW - PHARMACEUTICAL industry
N1 - Accession Number: 21936493; Lott, J.P. 1 Katz, K.A. 2,3; Email Address: keimeth.kutz@post.harvard.edu; Affiliation: 1: University of Pennsylvania School of Medicine, Philadelphia, PA, U.S.A. 2: Food and Drug Administration, CDER/OND/OPE3/DDDP, W02 2 RMS 187, 10903 New Hampshire Ave., Silver Spring, MD 20903, U.S.A. 3: Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, 2 Maloney, Philadelphia, PA 19104, U.S.A.; Source Info: Sep2006, Vol. 155 Issue 3, p635; Subject Term: LETTERS to the editor; Subject Term: PHARMACEUTICAL industry; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Letter
L3 - 10.1111/j.1365-2133.2006.07386.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arnold Jr., Francis A.
AU - Dean, H. Trendley
AU - Jay, Philip
AU - Kuntson, John W.
T1 - Effect of Fluoridated Public Water Supplies on Dental Caries Prevalence.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2006/09//
VL - 84
IS - 9
M3 - Article
SP - 761
EP - 764
PB - World Health Organization
SN - 00429686
AB - The article focuses on the epidemiological study regarding the addition of fluorides to public water supplies conducted by the Public Health Service together with universities and city officials in Grand Rapids and Muskegon, Michigan. The Grand Rapids-Muskegon study showed a striking reduction in the amount of dental caries for deciduous as well as permanent teeth. Moreover, the study also shows that the beneficial effects of fluoridated water are not confined only to persons drinking the water since birth.
KW - WATER fluoridation
KW - DENTAL caries
KW - EPIDEMIOLOGY -- Research
KW - WATER-supply engineering
KW - GRAND Rapids (Mich.)
KW - MUSKEGON (Mich.)
KW - MICHIGAN
N1 - Accession Number: 22378117; Arnold Jr., Francis A. 1 Dean, H. Trendley 2 Jay, Philip 3 Kuntson, John W. 4; Affiliation: 1: Director, National Institute of Dental Research, National Institutes of Health, Public Health Service 2: Secretary of Council on Dental Research, American Dental Association 3: Professor of Dentistry, University of Michigan School of Dentistry 4: Chief Dental Officer, Public Health Service; Source Info: Sep2006, Vol. 84 Issue 9, p761; Subject Term: WATER fluoridation; Subject Term: DENTAL caries; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: WATER-supply engineering; Subject Term: GRAND Rapids (Mich.); Subject Term: MUSKEGON (Mich.); Subject Term: MICHIGAN; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Seymour, Sally M.
AU - Sulliuan, Eugene J.
AU - Chowdhury, Badnd A.
AU - Meyer, Robert J.
AU - Davi, Ruthanna C.
T1 - Comments on the Salmeterol Multicenter Asthma Research Trial.
JO - CHEST
JF - CHEST
Y1 - 2006/09//
VL - 130
IS - 3
M3 - Letter
SP - 930
EP - 931
SN - 00123692
AB - A letter to the editor is presented in response to an article about the function of the Salmeterol Multicenter Asthma Research Trial published in previous issue.
KW - LETTERS to the editor
KW - ASTHMA
N1 - Accession Number: 22447367; Seymour, Sally M. 1; Email Address: sally.seymour@fda.hhs.gov Sulliuan, Eugene J. 1 Chowdhury, Badnd A. 1 Meyer, Robert J. 1 Davi, Ruthanna C. 1; Affiliation: 1: Food and Drug Administration Silver Spring, MD; Source Info: Sep2006, Vol. 130 Issue 3, p930; Subject Term: LETTERS to the editor; Subject Term: ASTHMA; Number of Pages: 2p; Document Type: Letter
L3 - 10.1378/chest.130.3.930a
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mills, Carrie
AU - Stephan, Sharon Hoover
AU - Moore, Elizabeth
AU - Weist, Mark D.
AU - Daly, Brian P.
AU - Edwards, Michele
T1 - The President’s New Freedom Commission: Capitalizing on Opportunities to Advance School-Based Mental Health Services.
JO - Clinical Child & Family Psychology Review
JF - Clinical Child & Family Psychology Review
Y1 - 2006/09//
VL - 9
IS - 3/4
M3 - Article
SP - 149
EP - 161
PB - Springer Science & Business Media B.V.
SN - 10964037
AB - The report from President George W. Bush’s New Freedom Commission on Mental Health (NFC), Achieving the Promise: Transforming Mental Health Care in America(2003), proposes goals and recommendations for improving mental health services. This report has significant implications for the delivery of mental health services through the schools. A focused discussion of the potential opportunities and challenges of implementing NFC recommendations related to school-based mental health is presented. Strategies for addressing five key areas at the intersection of school mental health and the Commission’s recommendations include: stigma reduction, suicide prevention, expansion and improvement of school mental health, and screening and treatment of co-occurring mental health and substance abuse disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Child & Family Psychology Review is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health policy
KW - MENTAL health services
KW - SCHOOL health services
KW - MENTAL health
KW - MEDICAL policy
KW - mental health
KW - New freedom commission
KW - policy
KW - school
N1 - Accession Number: 23355262; Mills, Carrie 1 Stephan, Sharon Hoover 1; Email Address: sstephan@psych.umaryland.edu Moore, Elizabeth 1 Weist, Mark D. 1 Daly, Brian P. 1 Edwards, Michele 2; Affiliation: 1: Center for School Mental Health Analysis and Action, University of Maryland School of Medicine, Baltimore, Maryland 2: Substance Abuse and Mental Health Services Administration (SAMHSA), Washington, DC; Source Info: Sep2006, Vol. 9 Issue 3/4, p149; Subject Term: MENTAL health policy; Subject Term: MENTAL health services; Subject Term: SCHOOL health services; Subject Term: MENTAL health; Subject Term: MEDICAL policy; Author-Supplied Keyword: mental health; Author-Supplied Keyword: New freedom commission; Author-Supplied Keyword: policy; Author-Supplied Keyword: school; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 13p; Document Type: Article
L3 - 10.1007/s10567-006-0003-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Persiani, Stefano
AU - D'Amato, Massimo
AU - Jakate, Abhijeet
AU - Roy, Partha
AU - Wangsa, Julie
AU - Kapil, Ram
AU - Rovati, Lucio C
T1 - Pharmacokinetic Profile of Dexloxiglumide.
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
Y1 - 2006/09//
VL - 45
IS - 12
M3 - Article
SP - 1177
PB - Springer Science & Business Media B.V.
SN - 03125963
AB - Dexloxiglumide is a potent and selective cholecystokinin type 1 (CCK1) receptor antagonist currently under development in a variety of diseases affecting the gastrointestinal tract such as gastro-oesophageal reflux disease, irritable bowel syndrome (IBS), functional dyspepsia, constipation and gastric emptying disorders. In female patients with constipation-predominant IBS, clinical efficacy has been demonstrated following administration of dexloxiglumide 200mg three times daily. Dexloxiglumide is rapidly and extensively absorbed after single oral administration in humans with an absolute bioavailability of 48%. The incomplete bioavailability is due to both incomplete absorption and hepatic first-pass effect. Following multiple-dose administration of 200mg three times daily, the accumulation is predictable, indicating time-independent pharmacokinetics. In addition, dexloxiglumide pharmacokinetics are dose-independent after both single and repeated oral three-times-daily doses in the dose range 100–400mg. Dexloxi-glumide absorption window extends from the jejunum to the colon and the drug is a substrate and a weak inhibitor of P-glycoprotein and multidrug resistance protein 1. Plasma protein binding of dexloxiglumide is 94–98% and the drug has a moderate to low volume of distribution in humans. Systemic clearance of dexloxi-glumide is moderate and cytochrome P450 (CYP) 3A4/5 and CYP2C9 have been implicated in the metabolism of dexloxiglumide to produce O-demethyl dexloxi-glumide. This metabolite is further oxidised to dexloxiglumide carboxylic acid. These two major metabolites (accounting for up to 50% of dexloxiglumide elimination) have been identified. However, in human plasma the unchanged drug represents the major (up to 91%) component of the metabolic profile. The parent drug is believed to be the major contributor to the efficacy of the compound, since its major metabolites are pharmacologically inactive. In addition, the drug is a single isomer chiral drug (eutomer) that does not undergo chiral inversion into its pharmacologically inactive enantiomer (distomer). After oral administration of C-dexloxiglumide, radioactivity is mainly excreted in bile and in faeces (74% of dose) with much lower excretion in urine (20% of dose). Renal excretion of unchanged dexloxiglumide is low (7% of dose in urine and faeces, 1% of dose in urine) and is dose-independent in the dose range 100–400mg. As the kidney is a minor contributor to the elimination of dexloxiglumide and/or its metabolites in humans, the pharmacokinetics of the drug should not be affected in patients with renal insufficiency. The pharmacokinetics of dexloxiglumide are also not affected by age, sex and administration with a high-fat breakfast. Mild and moderate liver impairment do not affect the pharmacokinetics of dexloxiglumide but severe liver impairment causes increases in systemic exposure to dexloxiglumide and O-demethyl dexloxiglumide. Thus, the drug should be prescribed with caution in patients with severe hepatic impairment even though no dose adjustment is warranted. The results of different drug interaction studies have indicated that no clinically relevant metabolic and concomitant drug-drug interactions are expected during the clinical use of dexloxiglumide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Pharmacokinetics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHOLECYSTOKININ
KW - DRUG receptors
KW - PHARMACOKINETICS
KW - IRRITABLE colon
KW - GASTROINTESTINAL system
N1 - Accession Number: 23276713; Persiani, Stefano 1; Email Address: stefano.persiani@rotta.com D'Amato, Massimo 1 Jakate, Abhijeet 2 Roy, Partha 3 Wangsa, Julie 4 Kapil, Ram 2 Rovati, Lucio C 1; Affiliation: 1: Departments of Clinical Pharmacology and Drug Metabolism, Pharmacokinetics and Dynamics, Rotta Research Laboratorium-Rottapharm, Monza, Italy. 2: Department of Clinical Pharmacology and Drug Dynamics, Forest Research Institute Inc., Jersey City, New Jersey, USA. 3: Pulmonary and Allergy Drug Products, Office of Clinical Pharmacology, US Food and Drug Administration, Rockville, Maryland, USA. 4: Department of Bioanalytical and Drug Metabolism, Forest Research Institute Inc., Farmingdale, New Jersey, USA.; Source Info: 2006, Vol. 45 Issue 12, p1177; Subject Term: CHOLECYSTOKININ; Subject Term: DRUG receptors; Subject Term: PHARMACOKINETICS; Subject Term: IRRITABLE colon; Subject Term: GASTROINTESTINAL system; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Evans, Jacquelyn R.
AU - Lou Short, Billie
AU - Van Meurs, Krisa
AU - Cheryl Sachs, Hari
T1 - Cardiovascular support in preterm infants
JO - Clinical Therapeutics
JF - Clinical Therapeutics
Y1 - 2006/09//
VL - 28
IS - 9
M3 - Article
SP - 1366
EP - 1384
SN - 01492918
AB - Abstract: Background:: Despite increasing investigation in the area of cardiovascular instability in preterm infants, huge gaps in knowledge remain. None of the current treatments for hypotension, including the use of inotropic agents, have been well studied in the preterm population, and data regarding safety and efficacy are lacking. Thus, the labeling information regarding the use of inotropes as therapeutic agents in this population is inadequate. Objective:: This article reviews the current deficiencies in knowledge with respect to measuring and achieving normal organ perfusion; summarizes the clinical, methodological, and ethical issues to consider when designing trials to evaluate medications for hemodynamic instability in the preterm neonate; and proposes 2 possible trial designs. Unanswered questions and potential obstacles for the systematic study of drugs to treat cardiovascular instability in preterm neonates are discussed. Methods:: The neonatal Cardiology Group was established in 2003 by the US Food and Drug Administration (FDA) and the National Institute of Child Health and Human Development (NICHD) as part of the Newborn Drug Development Initiative. The Cardiology Group conducted a number of teleconferences and one meeting to develop a document addressing gaps in knowledge regarding cardiovascular drugs commonly used in low-birth-weight neonates and possible approaches to investigate these drugs. This work was presented at a workshop cosponsored by the NICHD and the FDA eld in March 2004 in Baltimore, Maryland. Information for this article was gathered during this initiative. Results:: To develop rational, evidence-based guidelines corroborated by robust scientific data for cardiovascular support in newborns, well-designed and adequately powered pharmacologic studies and clinical trials are needed to evaluate the safety and efficacy of inotropic agents and to determine the short- and long-term effects of these drugs. Trials investigating the currently available and novel therapies for cardiovascular instability in neonates will provide information that can be incorporated into product labeling and a scientific framework for cardiovascular management in critically ill neonates. The Cardiology Group identified and prioritized 2 conditions for investigation of therapeutic options for the management of neonatal cardiovascular instability: (1) cardiovascular instability in preterm neonates; and (2) cardiac dysfunction in neonates after cardiopulmonary bypass surgery. Key research questions in the area of cardiovascular instability in the preterm infant include determining optimal blood pressure (BP) in preterm infants; identifying better measures than BP to determine organ perfusion; optimizing hemodynamic treatments; and clarifying any associations between BP or therapy for low BP and mortality, intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, retinopathy of prematurity, and neurodevelopmental outcome. The Cardiology Group concluded that the study of inotropic agents in neonates using outcomes of information contained in this article was published in part in a supplement to Pediatrics, 2006. This work was also presented, in part, at the NICHD/FDA Newborn Drug Development Initiative Workshop, March 29-30, 2004, Baltimore, Maryland. portance to patients will require a complicated trial design to address the elements discussed. The group proposed 2 clinical trial designs: (1) a placebo-controlled trial with rescue therapy for symptomatic infants; and (2) a targeted BP trial. Conclusion:: This summary is intended to stimulate and assist future research in the area of cardiovascular support for preterm infants. [Copyright &y& Elsevier]
AB - Copyright of Clinical Therapeutics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRITICAL care medicine
KW - PREMATURE infants
KW - NEONATAL intensive care
KW - INFANT health services
KW - hemodynamic instability
KW - hypotension
KW - infant-newborn
KW - inotrope
KW - neonatal intensive care unit
KW - shock
N1 - Accession Number: 22795680; Evans, Jacquelyn R. 1; Email Address: evans@email.chop.edu Lou Short, Billie 2 Van Meurs, Krisa 3 Cheryl Sachs, Hari 4,5; Affiliation: 1: Division of Neonatology, Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2: Division of Neonatology, Children's National Medical Center, and George Washington University School of Medicine, Washington, DC, USA 3: Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Palo Alto, California, USA 4: Office of Counter-Terrorism and Pediatric Drug Development, US Food and Drug Administration, Rockville, Maryland, USA 5: George Washington University School of Medicine, Washington, DC, USA; Source Info: Sep2006, Vol. 28 Issue 9, p1366; Subject Term: CRITICAL care medicine; Subject Term: PREMATURE infants; Subject Term: NEONATAL intensive care; Subject Term: INFANT health services; Author-Supplied Keyword: hemodynamic instability; Author-Supplied Keyword: hypotension; Author-Supplied Keyword: infant-newborn; Author-Supplied Keyword: inotrope; Author-Supplied Keyword: neonatal intensive care unit; Author-Supplied Keyword: shock; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.clinthera.2006.09.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ward, Robert M.
AU - Benitz, William E.
AU - Benjamin, Daniel K.
AU - Blackmon, Lillian
AU - Giacoia, George P.
AU - Hudak, Mark
AU - Lasky, Tamar
AU - Rodriguez, William
AU - Selen, Arzu
T1 - Criteria supporting the study of drugs in the newborn
JO - Clinical Therapeutics
JF - Clinical Therapeutics
Y1 - 2006/09//
VL - 28
IS - 9
M3 - Article
SP - 1385
EP - 1398
SN - 01492918
AB - Abstract: Background:: Profound changes in the development and the maturation of neonates'' organs and organ systems over variable periods of time potentially place neonates at increased risk and/or at different risks compared with adults or older children on exposure to pharmaceutical agents. Most studies of drugs in neonates focus on pharmacokinetic and pharmacodynamic end points and include insufficient numbers of patients to permit evaluation of safety. Only one fourth to one third of approved drugs have received adequate pediatric study to permit labeling for treatment of all appropriate pediatric populations. Objective:: The initial goal of the Newborn Drug Prioritization Group was to develop a reproducible, objective process for evaluating drugs most in need of study in the neonatal population based on a universally acceptable priority ranking. The criteria would be applicable across therapeutic classes and would identify those drugs for which immediate study was most needed. Methods:: Because the therapeutic requirements of the neonate are unique in comparison to older infants and children, the National Institute of Child Health and Human Development and the US Food and Drug Administration (FDA) developed the Newborn Drug Development Initiative to address the limited study of off-patent drugs in newborns. In March 2003, they convened a meeting of pediatric pharmacologists and pediatric specialists from the FDA, the American Academy of Pediatrics, the National Institutes of Health, and academic institutions to discuss how to increase the study of drugs for the newborn. One of the working groups was charged to develop generic criteria for overall prioritization of drugs for study in newborns. Because resources are limited, and not all drugs identified by the 4 clinically focused working groups can receive study at the same time, a process for priority ranking is necessary. Results:: The panel identified 4 general categories containing different numbers of criteria as important for ranking drugs for priority investigation: (1) the disease and indication, including elements such as the potential for adverse outcomes, frequency in newborns, and level of evidence for treatment of newborns; (2) drug characteristics, including elements such as duration of dosing, lack of age-appropriate formulation, clinically relevant drug-drug and drug-disease interactions, and drug disposition in newborns; (3) feasibility and methodology for newborn studies, including both analytical considerations and clinical end points; and (4) the ethical basis for study, including elements to address benefit or harm due to exposure to the study drug, study methodology, and benefit of the new treatment relative to established standard therapy. Based on these categories, a list of criteria to warrant study of a drug in newborns was developed. Conclusion:: A process for judicious use of limited resources to rectify these deficiencies remains an urgent public health need. [Copyright &y& Elsevier]
AB - Copyright of Clinical Therapeutics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EFFECT of drugs on infants
KW - PEDIATRICS
KW - CHILDREN -- Health
KW - NEWBORN infants
KW - drugs prioritization
KW - neonatal therapeutics
KW - newborns
KW - pediatric study
N1 - Accession Number: 22795681; Ward, Robert M. 1; Email Address: robert.ward@hsc.utah.edu Benitz, William E. 2 Benjamin, Daniel K. 3 Blackmon, Lillian 4 Giacoia, George P. 5 Hudak, Mark 6 Lasky, Tamar 7 Rodriguez, William 8 Selen, Arzu 9; Affiliation: 1: Department of Pediatrics and the Pediatric Pharmacology Program, University of Utah, Salt Lake City, Utah, USA 2: Department of Pediatrics, Stanford University School of Medicine, and Lucile Packard Children's Hospital, Palo Alto, California, USA 3: Department of Pediatrics, Duke University, and Duke Clinical Research Institute, Durham, North Carolina, USA 4: Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA 5: Pediatric Pharmacology Research Unit Network, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 6: Department of Pediatrics, University of Florida atjacksonville, Jacksonville, Florida, USA 7: National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 8: Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA 9: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Springs, Maryland, USA; Source Info: Sep2006, Vol. 28 Issue 9, p1385; Subject Term: EFFECT of drugs on infants; Subject Term: PEDIATRICS; Subject Term: CHILDREN -- Health; Subject Term: NEWBORN infants; Author-Supplied Keyword: drugs prioritization; Author-Supplied Keyword: neonatal therapeutics; Author-Supplied Keyword: newborns; Author-Supplied Keyword: pediatric study; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.clinthera.2006.09.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ghanem, Mohamed M.
AU - Battelli, Lori A.
AU - Mercer, Robert R.
AU - Scabilloni, James F.
AU - Kashon, Michael L.
AU - Ma, Jane Y. C.
AU - Nath, Joginder
AU - Hubbs, Ann F.
T1 - Apoptosis and Bax Expression are Increased by Coal Dust in the Polycyclic Aromatic Hydrocarbon-Exposed Lung.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/09//
VL - 114
IS - 9
M3 - Article
SP - 1367
EP - 1373
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Miners inhaling respirable coal dust (CD) frequently develop coal workers' pneumoconiosis, a dust-associated pneumoconiosis characterized by lung inflammation and variable fibrosis. Many coal miners are also exposed to polycyclic aromatic hydrocarbon (PAH) components of diesel engine exhaust and cigarette smoke, which may contribute to lung disease in these workers. Recently, apoptosis was reported to play a critical role in the development of another pneumoconiosis of miners, silicosis. In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs. METHODS: We investigated the hypothesis that apoptosis plays a critical role in lung injury and down-regulation of CYP1A1 induction in mixed exposures to CD and PAHs. We exposed rats intratracheally to 0.0, 2.5, 10.0, 20.0, or 40.0 mg/rat CD and, 11 days later, to intraperitoneal β-naphthoflavone (BNF), a PAH. In another group of rats exposed to CD and BNF, caspase activity was inhibited by injection of the pan-caspase inhibitor Q-VD-OPH [quinoline-Val-Asp (OMe)-CH2-OPH]. RESULTS: In rats exposed to BNF, CD exposure increased alveolar expression of the proapoptotic mediator Bax but decreased CYP1A1 induction relative to BNF exposure alone. Pan-caspase inhibition decreased CD-associated Bax expression and apoptosis but did not restore CYP1A1 activity. Further, CD-induced lung inflammation and alveolar epithelial cell hypertrophy and hyperplasia were not suppressed by caspase inhibition. CONCLUSIONS: Combined BNF and CD exposure increased Bax expression and apoptosis in the lung, but Bax and apoptosis were not the major determinants of early lung injury in this model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Apoptosis
KW - Coal dust
KW - Polycyclic aromatic hydrocarbons
KW - Cytochromes
KW - Biological response modifiers
KW - Lungs -- Dust diseases
KW - Metabolism
KW - Miners
KW - Fibrosis
KW - Silicosis
KW - apoptosis
KW - Bax
KW - caspase
KW - coal dust
KW - CYP1A1
KW - CYP2B1
KW - modifiers
KW - pneumoconiosis
KW - polycyclic aromatic hydrocarbons
KW - xenobiotic metabolism
N1 - Accession Number: 22421717; Ghanem, Mohamed M. 1,2; Battelli, Lori A. 1,2; Mercer, Robert R. 2; Scabilloni, James F. 2; Kashon, Michael L. 2; Ma, Jane Y. C. 2; Nath, Joginder 1; Hubbs, Ann F. 2; Email Address: Ahubbs@cdc.gov; Affiliations: 1: Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia, USA; 2: Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: Sep2006, Vol. 114 Issue 9, p1367; Thesaurus Term: Apoptosis; Thesaurus Term: Coal dust; Thesaurus Term: Polycyclic aromatic hydrocarbons; Subject Term: Cytochromes; Subject Term: Biological response modifiers; Subject Term: Lungs -- Dust diseases; Subject Term: Metabolism; Subject Term: Miners; Subject Term: Fibrosis; Subject Term: Silicosis; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: Bax; Author-Supplied Keyword: caspase; Author-Supplied Keyword: coal dust; Author-Supplied Keyword: CYP1A1; Author-Supplied Keyword: CYP2B1; Author-Supplied Keyword: modifiers; Author-Supplied Keyword: pneumoconiosis; Author-Supplied Keyword: polycyclic aromatic hydrocarbons; Author-Supplied Keyword: xenobiotic metabolism; Number of Pages: 7p; Document Type: Article
L3 - 10.1289/ehp.8906
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Collins, Thomas F.X.
AU - Sprando, Robert L.
AU - Black, Thomas N.
AU - Olejnik, Nicholas
AU - Eppley, Robert M.
AU - Alam, Hamida Z.
AU - Rorie, James
AU - Ruggles, Dennis I.
T1 - Effects of zearalenone on in utero development in rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/09//
VL - 44
IS - 9
M3 - Article
SP - 1455
EP - 1465
SN - 02786915
AB - Abstract: Zearalenone (ZE), an estrogenic mycotoxin produced by Fusarium graminearum or F. roseum, is one of the most common contaminants of cereal grains world-wide. The objective of this study was to determine the effects of ZE on in utero development of rats. Pregnant female Charles River Sprague-Dawley rats were gavaged once daily with ZE (in corn oil) at doses of 0, 1, 2, 4, or 8mg/kg body weight on gestation days (GD) 6–19. All females survived to cesarean section on GD 20. At cesarean section, reproductive and developmental parameters were measured and blood was taken for hormone analysis. Dose-related decreases were seen in maternal feed consumption and body weight gain in all treated groups. Delayed fetal development was linked to maternal toxicity. Fetal body weight was significantly decreased in both sexes in all treated groups. ZE retarded skeletal ossification at 4 and 8mg/kg. Fetal anogenital index (anogenital distance normalized for body weight) was increased in all treated groups, indicating an androgenic effect of ZE during fetal development. Fetal viability was significantly decreased at 8mg/kg; significant decreases were observed in number of viable fetuses, and number of litters totally resorbed. At 4 and 8mg/kg, maternal liver–body weight ratios were significantly increased and organ–brain weight ratios for weights of liver, heart, spleen, kidneys, and ovaries were significantly decreased. Gonadotropins (LH, FSH, and prolactin) and sex steroids (progesterone and estradiol) were analyzed from the blood serum obtained at cesarean section. LH in the 0, 1, 2, and 4mg/kg groups showed minimal variation, and slightly increased at 8mg/kg. FSH was decreased in the 1, 2, and 4mg/kg groups, but the level at 8mg/kg was slightly higher than the control level. Prolactin level was not affected at 1mg/kg, slightly increased at 2 and 4mg/kg, and significantly increased at 8mg/kg. Progesterone was decreased at 2, 4, and 8mg/kg and the decreases were significant at 2 and 4mg/kg. Estradiol level was not affected at 1mg/kg, but dose-related decreases were observed at 2, 4, and 8mg/kg. Only the 8mg/kg level of estradiol was significantly decreased. In summary, ZE was maternally toxic and fetotoxic but not teratogenic. The increased anogenital distance observed in male and female fetuses was considered a hormonal change rather than a teratologic response. The increased anogenital distance indicated an androgenic effect. Based on the dose-related maternal and fetal toxicity in all treated groups, the NOEL for reproductive and teratogenic effects was less than 1mg/kg. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOTOXINS
KW - RATS
KW - MICROBIAL toxins
KW - FUSARIUM
KW - BLOOD
KW - STEROIDS
KW - BLOOD plasma
KW - analysis of covariance ( ANCOVA )
KW - analysis of variance ( ANOVA )
KW - Developmental toxicity
KW - Estrogenic mycotoxin
KW - follicle stimulating hormone ( FSH )
KW - gestation day ( GD )
KW - least significant difference ( LSD )
KW - luteinizing hormone ( LH )
KW - Rat
KW - Zearalenone
KW - zearalenone ( ZE )
N1 - Accession Number: 21495355; Collins, Thomas F.X.; Email Address: tcollins@cfsan.fda.gov Sprando, Robert L. 1 Black, Thomas N. 1 Olejnik, Nicholas 1 Eppley, Robert M. 1 Alam, Hamida Z. 1 Rorie, James 1 Ruggles, Dennis I. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA; Source Info: Sep2006, Vol. 44 Issue 9, p1455; Subject Term: MYCOTOXINS; Subject Term: RATS; Subject Term: MICROBIAL toxins; Subject Term: FUSARIUM; Subject Term: BLOOD; Subject Term: STEROIDS; Subject Term: BLOOD plasma; Author-Supplied Keyword: analysis of covariance ( ANCOVA ); Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: Estrogenic mycotoxin; Author-Supplied Keyword: follicle stimulating hormone ( FSH ); Author-Supplied Keyword: gestation day ( GD ); Author-Supplied Keyword: least significant difference ( LSD ); Author-Supplied Keyword: luteinizing hormone ( LH ); Author-Supplied Keyword: Rat; Author-Supplied Keyword: Zearalenone; Author-Supplied Keyword: zearalenone ( ZE ); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.fct.2006.04.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Hee-Ra
AU - Ahn, Hyun-Joo
AU - Kim, So-Hee
AU - Lee, Cherl-Ho
AU - Byun, Myung-Woo
AU - Lee, Gil-Woong
T1 - Determination of the phytic acid levels in infant foods using different analytical methods
JO - Food Control
JF - Food Control
Y1 - 2006/09//
VL - 17
IS - 9
M3 - Article
SP - 727
EP - 732
SN - 09567135
AB - Abstract: The analytical methods of phytic acid determination in infant foods were evaluated, and then, the method suggested in this study was applied to determine the phytic acid level in commercially available infant foods for both the flour and paste types. The spectrophotometric (AOAC and Wade reagent) and chromatographic (GC-FID and HPLC) methods were compared, and the spectrophotometrically determined value showed higher phytic acid levels than that of the chromatographic methods (p <0.05). The AOAC method showed a complete recovery for the infant foods after spiking the phytic acid, while a poor recovery was observed by GC-FID and HPLC-RI. The average levels of phytic acid in the infant foods determined by the AOAC methods were 363mg/100g for the flour type and 46.3mg/100g for the paste type on a wet basis. When the phytic acid level was converted into a dry basis, the phytic acid levels of the paste types were much higher than that of the flour type. Thus, the amount of phytic acid intake per meal was calculated, and the phytic acid level per meal was high in the paste type as wells as the flour type. Therefore, a problem with phytic acid might be considered for the infant foods of both the flour and paste types. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEXOSE phosphates
KW - BABY foods
KW - FLOUR
KW - PASTE
KW - AOAC
KW - GC-FID
KW - HPLC
KW - Infant foods
KW - Phytic acid
KW - Wade reagent
N1 - Accession Number: 20254408; Park, Hee-Ra 1,2; Email Address: heera@kfda.go.kr Ahn, Hyun-Joo 3 Kim, So-Hee 4 Lee, Cherl-Ho 1 Byun, Myung-Woo 3 Lee, Gil-Woong 4; Affiliation: 1: School of Life Sciences and Biotechnology, Korea University, Seoul 136-071, Korea 2: Korea Food and Drug Exposure Assessment Division, National Institute of Toxicological Research, Seoul 122-704, Korea 3: Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-353, Korea 4: Korea Food and Drug Administration, Seoul Regional, Seoul 171-2, Korea; Source Info: Sep2006, Vol. 17 Issue 9, p727; Subject Term: HEXOSE phosphates; Subject Term: BABY foods; Subject Term: FLOUR; Subject Term: PASTE; Author-Supplied Keyword: AOAC; Author-Supplied Keyword: GC-FID; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Infant foods; Author-Supplied Keyword: Phytic acid; Author-Supplied Keyword: Wade reagent; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 311211 Flour Milling; NAICS/Industry Codes: 311214 Rice milling and malt manufacturing; NAICS/Industry Codes: 311824 Dry Pasta, Dough, and Flour Mixes Manufacturing from Purchased Flour; NAICS/Industry Codes: 325520 Adhesive Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.foodcont.2005.05.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guan, D.
AU - Kniel, K.
AU - Calci, K.R.
AU - Hicks, D.T.
AU - Pivarnik, L.F.
AU - Hoover, D.G.
T1 - Response of four types of coliphages to high hydrostatic pressure
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/09//
VL - 23
IS - 6
M3 - Article
SP - 546
EP - 551
SN - 07400020
AB - Abstract: Pressure inactivation of four types of coliphages, ϕX 174 (ssDNA virus), MS2 (ssRNA virus), λ imm434 (dsDNA virus) and T4 (dsDNA virus), was studied to evaluate their potential as human enteric viral surrogates for use in validation of commercial pressure processing treatments. Phage ϕX 174 demonstrated an unexpected high resistance to pressure with no more than 1-log10 reduction observed following exposures to 350–600MPa. There was no greater than 1-log10 reduction below 500MPa for MS2 in modified phosphate-buffered saline, but a 3.3-log10 reduction was observed for MS2 pressurized at 600MPa. Coliphages λ imm434 and T4 were relatively sensitive to pressure in demonstrating inactivation at 350MPa. At 21°C, λ imm434 was inactivated in modified phosphate-buffered saline or Dulbecco''s Modified Eagle''s Medium plus 5% fetal bovine sera by at least 7.5-log10 when exposed to 400MPa for 5min. Treatment at 450MPa for 5min was necessary to obtain a log10 reduction of 6–7 for T4. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS inactivation
KW - BACTERIOPHAGE T4
KW - HYDROSTATIC pressure
KW - PHOSPHATES
KW - Coliphage
KW - High hydrostatic pressure
N1 - Accession Number: 20350150; Guan, D. 1 Kniel, K. 1 Calci, K.R. 2 Hicks, D.T. 3 Pivarnik, L.F. 4 Hoover, D.G. 1; Email Address: dgh@udel.edu; Affiliation: 1: Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716-2150, USA 2: Gulf Coast Seafood Laboratory, US Food and Drug Administration, Dauphin Island, AL 36528, USA 3: Sea Grant College Program, University of Delaware, Lewes, DE 19958, USA 4: Department of Nutrition and Food Sciences, University of Rhode Island, RI 02881, USA; Source Info: Sep2006, Vol. 23 Issue 6, p546; Subject Term: VIRUS inactivation; Subject Term: BACTERIOPHAGE T4; Subject Term: HYDROSTATIC pressure; Subject Term: PHOSPHATES; Author-Supplied Keyword: Coliphage; Author-Supplied Keyword: High hydrostatic pressure; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fm.2005.09.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jablonski, Joe
T1 - Book review: Handbook of Food Analytical Chemistry
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/09//
VL - 23
IS - 6
M3 - Book Review
SP - 605
EP - 606
SN - 07400020
N1 - Accession Number: 20350158; Jablonski, Joe 1; Email Address: joseph.jablonski@cfsan.fda.gov; Affiliation: 1: US Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Road, Summit-Argo IL 60501, USA; Source Info: Sep2006, Vol. 23 Issue 6, p605; Number of Pages: 2p; Document Type: Book Review
L3 - 10.1016/j.fm.2005.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chunilu Zhan
AU - Friedman, Bernard
AU - Mosso, Andrew
AU - Pronovost, Peter
T1 - MARKET WATCH: Medicare Payment For Selected Adverse Events: Building The Business Case For Investing In Patient Safety.
JO - Health Affairs
JF - Health Affairs
Y1 - 2006/09//Sep/Oct2006
VL - 25
IS - 5
M3 - Article
SP - 1386
EP - 1393
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - This study estimates that Medicare extra payments under the hospital prospective payment system (PPS) range from about $700 per case of decubitus ulcer to $9,000 per case of postoperative sepsis in the five types of adverse events identifiable in Medicare claims. Medicare extra payment for the five types of events totals more than $300 million per year, accounting for 0.27 percent of annual Medicare hospital spending. But these extra payments cover less than a third of the extra costs incurred by hospitals in treating these adverse events. We conclude that both Medicare and hospitals gain financially by improving patient safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICARE
KW - HEALTH insurance
KW - MEDICAL care costs
KW - SEPTICEMIA
KW - MEDICAID
N1 - Accession Number: 22379717; Chunilu Zhan 1; Email Address: czhan@ahra.gov Friedman, Bernard 1 Mosso, Andrew 2 Pronovost, Peter 3; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland 2: Social and Scientific Systems Inc., Silver Spring, Maryland 3: Center for Innovations in Quality Patient Car, School of Medicine, Johns Hopkins University, Baltimore, Maryland; Source Info: Sep/Oct2006, Vol. 25 Issue 5, p1386; Subject Term: MEDICARE; Subject Term: HEALTH insurance; Subject Term: MEDICAL care costs; Subject Term: SEPTICEMIA; Subject Term: MEDICAID; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Document Type: Article
L3 - 10.1377/hlthaff.25.5.1386
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106368369
T1 - Marketwatch: Medicare payment for selected adverse events: building the business case for investing in patient safety: hospitals absorb most of the costs of treating five adverse medical care events in Medicare patients.
AU - Zhan C
AU - Friedman B
AU - Mosso A
AU - Pronovost P
Y1 - 2006/09//Sep/Oct2006
N1 - Accession Number: 106368369. Language: English. Entry Date: 20061201. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Adverse Health Care Event -- Economics
KW - Billing and Claims
KW - Medicare -- Economics
KW - Patient Safety
KW - Prospective Payment System
KW - Adverse Health Care Event
KW - Aged
KW - Aged, 80 and Over
KW - Comorbidity
KW - Diagnosis-Related Groups
KW - Female
KW - Hospitalization
KW - Male
KW - New York
KW - Patient Satisfaction
KW - Pilot Studies
KW - Postoperative Complications
KW - Quality Improvement
KW - Record Review
KW - Reimbursement Mechanisms
KW - Structured Interview
KW - Summated Rating Scaling
KW - United States
KW - Wrongful Death
KW - Human
SP - 1386
EP - 1393
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 25
IS - 5
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - This study estimates that Medicare extra payments under the hospital prospective payment system (PPS) range from about $700 per case of decubitus ulcer to $9,000 per case of postoperative sepsis in the five types of adverse events identifiable in Medicare claims. Medicare extra payment for the five types of events totals more than $300 million per year, accounting for 0.27 percent of annual Medicare hospital spending. But these extra payments cover less than a third of the extra costs incurred by hospitals in treating these adverse events. We conclude that both Medicare and hospitals gain financially by improving patient safety.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA. czhan@ahrq.gov
U2 - PMID: 16966737.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sing, Merrile
AU - Banthin, Jessica S.
AU - Selden, Thomas M.
AU - Cowan, Cathy A.
AU - Keehan, Sean P.
T1 - Reconciling Medical Expenditure Estimates from the MEPS and NHEA, 2002.
JO - Health Care Financing Review
JF - Health Care Financing Review
Y1 - 2006///Fall2006
VL - 28
IS - 1
M3 - Article
SP - 25
EP - 40
PB - HCFA ORDS Publications
SN - 01958631
AB - The Medical Expenditure Panel Survey (MEPS) and National Health Expenditure Accounts (NHEA) are often used for health care policy analysis and simulations because they contain comprehensive estimates of national health care expenditures. The NHEA are primarily based on aggregate provider revenue data, while MEPS is based on person-level data on health care expenditures. This article compares MEPS and NHEA expenditure estimates for 2002 and discusses the differences. When MEPS and the NHEA are adjusted to be on a consistent basis, their expenditure estimates differ by 13.8 percent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Care Financing Review is the property of HCFA ORDS Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - MEDICAL economics
KW - MEDICAL care costs
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 25003988; Sing, Merrile 1; Email Address: merrile.sing@ahrq.hhs.gov; Banthin, Jessica S. 1; Selden, Thomas M. 1; Cowan, Cathy A. 2; Keehan, Sean P. 2; Affiliations: 1: Agency for Healthcare Research and Quality (AHRQ); 2: Centers for Medicare & Medicaid Services (CMS); Issue Info: Fall2006, Vol. 28 Issue 1, p25; Thesaurus Term: MEDICAL care; Thesaurus Term: MEDICAL economics; Subject Term: MEDICAL care costs; Subject Term: MEDICAL policy; Subject: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sottile, Joseph
AU - Gnapragasam, Steve J.
AU - Novak, Thomas
AU - Kohler, Jeffrey L.
T1 - Detrimental Effects of Capacitance on High-Resistance-Grounded Mine Distribution Systems.
JO - IEEE Transactions on Industry Applications
JF - IEEE Transactions on Industry Applications
Y1 - 2006/09//Sep/Oct2006
VL - 42
IS - 5
M3 - Article
SP - 1333
EP - 1339
SN - 00939994
AB - Modern underground coal mines can be very large, having a total connected load in excess of 15 000 hp. These mines generally have many miles of high-power conveyor belts and 15 or more miles of high-voltage power cables at distribution voltages of 12.47, 13.2, 13.8, or 14.4 kV. The shielded cables used in mine power distribution systems have a significant level of capacitance, on the order of 110 pF/ft. This level of capacitance, in an extensive power distribution system at today's voltage levels, can cause significant charging currents during a ground fault. This paper addresses the potential detrimental effects of capacitance charging currents during line-to-ground faults in mine power distribution systems. A representative mine power system is modeled, and simulations with faults at various locations are conducted to evaluate the effects of this capacitance on the level of fault current and relay selectivity. This paper also includes results of capacitance measurements made on mine power feeder cables used to validate the simulation model. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Industry Applications is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH voltages
KW - SURFACE fault ruptures
KW - ELECTRIC power distribution
KW - ELECTRIC potential
KW - POWER transmission
KW - CABLE structures
KW - Charging current
KW - ground fault
N1 - Accession Number: 22616575; Sottile, Joseph 1; Email Address: jsottile@ieee.org Gnapragasam, Steve J. 2; Email Address: Steve.Gnapragasam@adsce.com Novak, Thomas 3; Email Address: tomnovak@vt.edu Kohler, Jeffrey L. 4; Email Address: JKohler@cdc.gov; Affiliation: 1: University of Kentucky, Lexington, KY 40506-0107 USA 2: ADS Consulting Engineers, New York, NY 10001 USA 3: Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 USA 4: National Institute for Occupational Safety and Health, Pittsburgh, PA 15236 USA; Source Info: Sep/Oct2006, Vol. 42 Issue 5, p1333; Subject Term: HIGH voltages; Subject Term: SURFACE fault ruptures; Subject Term: ELECTRIC power distribution; Subject Term: ELECTRIC potential; Subject Term: POWER transmission; Subject Term: CABLE structures; Author-Supplied Keyword: Charging current; Author-Supplied Keyword: ground fault; NAICS/Industry Codes: 221122 Electric Power Distribution; Number of Pages: 7p; Illustrations: 4 Black and White Photographs, 3 Diagrams, 7 Charts, 3 Graphs; Document Type: Article
L3 - 10.1109/TIA.2006.880844
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kuempel, E. D.
AU - Tran, C. L.
AU - Castranova, V.
AU - Bailer, A. J.
T1 - Lung Dosimetry and Risk Assessment of Nanoparticles: Evaluating and Extending Current Models in Rats and Humans.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2006/09//
VL - 18
IS - 10
M3 - Article
SP - 717
EP - 724
SN - 08958378
AB - Risk assessment of occupational exposure to nanomaterials is needed. Human data are limited, but quantitative data are available from rodent studies. To use these data in risk assessment, a scientifically reasonable approach for extrapolating the rodent data to humans is required. One approach is allometric adjustment for species differences in the relationship between airborne exposure and internal dose. Another approach is lung dosimetry modeling, which provides a biologically-based, mechanistic method to extrapolate doses from animals to humans. However, current mass-based lung dosimetry models may not fully account for differences in the clearance and translocation of nanoparticles. In this article, key steps in quantitative risk assessment are illustrated, using dose-response data in rats chronically exposed to either fine or ultrafine titanium dioxide (TiO 2 ), carbon black (CB), or diesel exhaust particulate (DEP). The rat-based estimates of the working lifetime airborne concentrations associated with 0.1% excess risk of lung cancer are approximately 0.07 to 0.3 mg/m 3 for ultrafine TiO 2 , CB, or DEP, and 0.7 to 1.3 mg/m 3 for fine TiO 2 . Comparison of observed versus model-predicted lung burdens in rats shows that the dosimetry models predict reasonably well the retained mass lung burdens of fine or ultrafine poorly soluble particles in rats exposed by chronic inhalation. Additional model validation is needed for nanoparticles of varying characteristics, as well as extension of these models to include particle translocation to organs beyond the lungs. Such analyses would provide improved prediction of nanoparticle dose for risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Threshold limit values (Industrial toxicology)
KW - Health risk assessment
KW - Drugs -- Dose-response relationship
KW - Rodents as laboratory animals
KW - Dosimetric medicine
KW - Allometry
KW - Airborne infection
KW - Titanium dioxide
N1 - Accession Number: 21194108; Kuempel, E. D. 1; Email Address: ekuempel@cdc.gov; Tran, C. L. 2; Castranova, V. 3; Bailer, A. J. 4; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: Institute of Occupational Medicine, Edinburgh, United Kingdom; 3: NIOSH Morgantown, West Virginia, USA; 4: Miami University, Oxford, Ohio, USA; Issue Info: Sep2006, Vol. 18 Issue 10, p717; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Health risk assessment; Subject Term: Drugs -- Dose-response relationship; Subject Term: Rodents as laboratory animals; Subject Term: Dosimetric medicine; Subject Term: Allometry; Subject Term: Airborne infection; Subject Term: Titanium dioxide; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/08958370600747887
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21194108&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Phalen, Robert F.
AU - Hoover, Mark D.
T1 - Aerosol Dosimetry Research Needs.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2006/09//
VL - 18
IS - 10
M3 - Article
SP - 841
EP - 843
SN - 08958378
AB - Information on the Aerosol Dosimetry Conference which was held at the Beckman Center of the National academies on the University of California in Irvine, California in October 2005. The conference was participated by 95 experts representing 53 organization from 12 different countries to discuss the state-of-the-art in estimating internal doses from inhaled aerosol particles and gases.
KW - Conferences & conventions
KW - Medicine -- Congresses
KW - Dosimetric medicine
KW - Dosage of drugs
KW - Irvine (Calif.)
KW - California
N1 - Accession Number: 21194106; Phalen, Robert F. 1; Email Address: rfphalen@uci.edu; Hoover, Mark D. 2; Affiliations: 1: Department of Community and Environmental Medicine, University of California, Irvine, California, USA; 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Sep2006, Vol. 18 Issue 10, p841; Subject Term: Conferences & conventions; Subject Term: Medicine -- Congresses; Subject Term: Dosimetric medicine; Subject Term: Dosage of drugs; Subject: Irvine (Calif.); Subject: California; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/08958370600748778
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21194106&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reddy, N.R.
AU - Tetzloff, R.C.
AU - Solomon, H.M.
AU - Larkin, J.W.
T1 - Inactivation of Clostridium botulinum nonproteolytic type B spores by high pressure processing at moderate to elevated high temperatures
JO - Innovative Food Science & Emerging Technologies
JF - Innovative Food Science & Emerging Technologies
Y1 - 2006/09//
VL - 7
IS - 3
M3 - Article
SP - 169
EP - 175
SN - 14668564
AB - Abstract: The effect of high pressure and high temperature treatments at various process times on the inactivation of spores of Clostridium botulinum nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B, suspended in phosphate buffer (0.067M, pH7.0) and a crabmeat blend was investigated. Spores of KAP8-B were less resistant to high pressure treatment than the spores of 2-B, 17-B, and KAP9-B in both phosphate buffer and crabmeat blend. No survivors of initial counts (>4.3logunits) of KAP8-B spores were detected in these menstura after processing at 827MPa and 60°C for 10min. The amount of inactivation of spores of 2-B, 17-B, and KAP9-B in phosphate buffer or crabmeat blend increased with the increase in processing time from 10 to 30min at 827MPa and 75°C. Similar inactivation patterns were observed for these spores in both phosphate buffer and crabmeat blend. A reduction of >6-logunits of 2-B, 17-B, and KAP9-B spores in phosphate buffer and crabmeat blend was observed at 827MPa and 75°C for a processing time of between 20 and 30min. Crabmeat blend as a suspension menstrum provided no protection against inactivation of spores of 2-B, 17-B, and KAP9-B by high pressure processing. High temperature (>95°C) and lower pressure (620MPa) treatments for up to 10min were also found to inactivate 17-B spores in phosphate buffer. Spores of nonproteolytic type B strains, 2-B, 17-B, KAP8-B, and KAP9-B in phosphate buffer and crabmeat blend can be inactivated by a combination of high pressure and temperature treatments. Industrial relevance: Spores of nonproteolytic type B strains of Clostridium botulinum are of primary concern because they have been involved in the foodborne botulism outbreaks associated with marine products. Foodborne botulism results from consumption of these foods in which C. botulinum has grown and produced neurotoxin. Recently, high pressure processing (HPP) received a great deal of interest because of its ability to destroy vegetative pathogens, viruses, and certain bacterial spores and results in a product with natural sensory, quality, and nutritional attributes. Currently, HPP is being evaluated at the National Center for Food Safety and Technology as an alternative to other traditional thermal processes for its ability to inactivate C. botulinum spores. In this study, the effects of high pressure in conjunction with moderate to elevated high temperatures on inactivation of C. botulinum nonproteolytic type B spores were investigated. Based on limited number of strains tested, HPP showed a potential of destroying spores of nonproteolytic type B strains of C. botulinum when process temperature is above 75°C. [Copyright &y& Elsevier]
AB - Copyright of Innovative Food Science & Emerging Technologies is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM botulinum
KW - FOOD industry
KW - HIGH temperatures
KW - BOTULISM
KW - Clostridium botulinum
KW - High pressure processing
KW - Inactivation
KW - Spores
N1 - Accession Number: 21767122; Reddy, N.R. 1; Email Address: rukma.reddy@fda.hhs.gov Tetzloff, R.C. 2 Solomon, H.M. 3 Larkin, J.W. 1; Affiliation: 1: National Center for Food Safety and Technology, Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA 2: National Center for Food Safety and Technology, Illinois Institute of Technology, 6502 S. Archer Road, Summit-Argo, IL 60501, USA 3: Food and Drug Administration, Division of Microbiological Studies, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Sep2006, Vol. 7 Issue 3, p169; Subject Term: CLOSTRIDIUM botulinum; Subject Term: FOOD industry; Subject Term: HIGH temperatures; Subject Term: BOTULISM; Author-Supplied Keyword: Clostridium botulinum; Author-Supplied Keyword: High pressure processing; Author-Supplied Keyword: Inactivation; Author-Supplied Keyword: Spores; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ifset.2006.03.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Simjee, Shabbir
AU - Zhang, Yifan
AU - McDermott, Patrick F.
AU - Donabedian, Susan M.
AU - Zervos, Marcus J.
AU - Meng, Jianghong
T1 - Heterogeneity of vat(E)-carrying plasmids in Enterococcus faecium recovered from human and animal sources
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2006/09//
VL - 28
IS - 3
M3 - Article
SP - 200
EP - 205
SN - 09248579
AB - Abstract: In this study, quinupristin/dalfopristin (Q/D)-resistant Enterococcus faecium isolates (33 from poultry farms and 1 from a human outpatient) with Q/D minimal inhibitory concentrations ranging from 4μg/mL to 32μg/mL were analysed. Polymerase chain reaction detected the presence of vat(E) in all isolates. Using pulsed-field gel electrophoresis (PFGE), 14 distinct PFGE patterns were identified. The human E. faecium isolate was distinguishable from the 33 farm isolates by PFGE. Southern hybridisation localised the vat(E) gene to an 11kb plasmid and resulted in five plasmid hybridisation types. The vat(E)-carrying plasmid from the human isolate showed a nearly identical hybridisation pattern to a plasmid from a farm isolate. This study showed that the vat(E) gene, conferring resistance to Q/D, was carried on different plasmids in a heterogeneous group of E. faecium, some of which may be acquired by E. faecium capable of infecting humans. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterococcus faecalis
KW - Plasmids
KW - Polymerase chain reaction
KW - DNA polymerases
KW - E. faecium
KW - Streptogramin resistance
KW - Virginiamycin
N1 - Accession Number: 22011236; Simjee, Shabbir 1; Zhang, Yifan 2; McDermott, Patrick F. 1; Donabedian, Susan M. 3; Zervos, Marcus J. 3; Meng, Jianghong 2; Email Address: jmeng@umd.edu; Affiliations: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD, USA; 2: Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; 3: Henry Ford Hospital, Detroit, MI, USA; Issue Info: Sep2006, Vol. 28 Issue 3, p200; Subject Term: Enterococcus faecalis; Subject Term: Plasmids; Subject Term: Polymerase chain reaction; Subject Term: DNA polymerases; Author-Supplied Keyword: E. faecium; Author-Supplied Keyword: Streptogramin resistance; Author-Supplied Keyword: Virginiamycin; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2006.04.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22011236&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Goldcamp, E. Michael
AU - Hendricks, Kitty J.
AU - Layne, Larry A.
AU - Myers, John R.
T1 - Nonfatal Injuries to Household Youth on Native American Operated Farms in the U.S., 2000.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2006/09//
VL - 11
IS - 3/4
M3 - Article
SP - 61
EP - 69
SN - 1059924X
AB - In 2000, there were an estimated 7,381 youth living on 9,556 U.S. farms operated by Native Americans. Most of these youth (5,454, 74%) lived on livestock operations (6,833 farms, 72%). In that year, youth living on Native American operated farms sustained an estimated 177 nonfatal injuries. The majority of all injuries to household youth (147, 83%) occurred on livestock operations. Males accounted for 112 (63%) of the injuries to household youth. Overall, household youth on Native American operated farms had an injury rate of 24.0 injuries per 1,000 household youth compared to a rate of 8.1 injuries per 1,000 household youth on all other minority-operated farms. The rate ratio for work-related-injuries to household youth on Native American farms compared to other minority-operated farms was 2.1. Although female youth on these farms experienced a similar non-work injury rate of 13.8 injuries per 1,000 female household youth compared to a rate of 15.1 injuries per 1,000 male household youth, the work-related injury rate for male youth (30.2 per 1,000 male household youth) was substantially higher than the work-related injury rate for female household youth (18.3 per 1,000 female household youth). These data indicate an elevated risk of injury for youth living on farms operated by Native Americans. This result is attributed to the large percentage of livestock operations for this population and the hazards associated with this type of farming. However, further research is needed to more fully understand these results and to guide culturally appropriate interventions within this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURE -- Research
KW - TEENAGERS
KW - NATIVE Americans
KW - TEENAGERS -- Wounds & injuries
KW - WOUNDS & injuries
KW - NATIVE Americans -- Agriculture
KW - MINORITIES
KW - FARMS -- Accidents
KW - LIVESTOCK
KW - Agriculture
KW - injuries
KW - minority
KW - Native American
KW - serveillance
KW - youth
N1 - Accession Number: 25757555; Goldcamp, E. Michael 1; Email Address: mgoldcamp@cdc.gov Hendricks, Kitty J. 1 Layne, Larry A. 1 Myers, John R. 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health; Source Info: 2006, Vol. 11 Issue 3/4, p61; Subject Term: AGRICULTURE -- Research; Subject Term: TEENAGERS; Subject Term: NATIVE Americans; Subject Term: TEENAGERS -- Wounds & injuries; Subject Term: WOUNDS & injuries; Subject Term: NATIVE Americans -- Agriculture; Subject Term: MINORITIES; Subject Term: FARMS -- Accidents; Subject Term: LIVESTOCK; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: injuries; Author-Supplied Keyword: minority; Author-Supplied Keyword: Native American; Author-Supplied Keyword: serveillance; Author-Supplied Keyword: youth; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 9p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1300/J096v11n03̱07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25757555&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldcamp, E. Michael
AU - Hendricks, Kitty J.
AU - Layne, Larry A.
AU - Myers, John R.
T1 - Nonfatal Injuries to Household Youth on Native American Operated Farms in the U.S., 2000.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2006/09//
VL - 11
IS - 3/4
M3 - Article
SP - 61
EP - 69
PB - Taylor & Francis Ltd
SN - 1059924X
AB - In 2000, there were an estimated 7,381 youth living on 9,556 U.S. farms operated by Native Americans. Most of these youth (5,454, 74%) lived on livestock operations (6,833 farms, 72%). In that year, youth living on Native American operated farms sustained an estimated 177 nonfatal injuries. The majority of all injuries to household youth (147, 83%) occurred on livestock operations. Males accounted for 112 (63%) of the injuries to household youth. Overall, household youth on Native American operated farms had an injury rate of 24.0 injuries per 1,000 household youth compared to a rate of 8.1 injuries per 1,000 household youth on all other minority-operated farms. The rate ratio for work-related-injuries to household youth on Native American farms compared to other minority-operated farms was 2.1. Although female youth on these farms experienced a similar non-work injury rate of 13.8 injuries per 1,000 female household youth compared to a rate of 15.1 injuries per 1,000 male household youth, the work-related injury rate for male youth (30.2 per 1,000 male household youth) was substantially higher than the work-related injury rate for female household youth (18.3 per 1,000 female household youth). These data indicate an elevated risk of injury for youth living on farms operated by Native Americans. This result is attributed to the large percentage of livestock operations for this population and the hazards associated with this type of farming. However, further research is needed to more fully understand these results and to guide culturally appropriate interventions within this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agriculture -- Research
KW - WOUNDS & injuries
KW - Wounds & injuries
KW - AGRICULTURE
KW - Livestock
KW - Teenagers
KW - Native Americans
KW - Minorities
KW - Farms -- Accidents
KW - Agriculture
KW - injuries
KW - minority
KW - Native American
KW - serveillance
KW - youth
N1 - Accession Number: 25757555; Goldcamp, E. Michael 1; Email Address: mgoldcamp@cdc.gov; Hendricks, Kitty J. 1; Layne, Larry A. 1; Myers, John R. 1; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health; Issue Info: 2006, Vol. 11 Issue 3/4, p61; Thesaurus Term: Agriculture -- Research; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Wounds & injuries; Thesaurus Term: AGRICULTURE; Thesaurus Term: Livestock; Subject Term: Teenagers; Subject Term: Native Americans; Subject Term: Minorities; Subject Term: Farms -- Accidents; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: injuries; Author-Supplied Keyword: minority; Author-Supplied Keyword: Native American; Author-Supplied Keyword: serveillance; Author-Supplied Keyword: youth; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 9p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1300/J096v11n03̱07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25757555&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105729761
T1 - Nonfatal injuries to household youth on Native American operated farms in the U.S., 2000.
AU - Goldcamp EM
AU - Hendricks KJ
AU - Layne LA
AU - Myers JR
Y1 - 2006/09//
N1 - Accession Number: 105729761. Language: English. Entry Date: 20080530. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Native Americans -- In Adolescence
KW - Wounds and Injuries -- Epidemiology -- In Adolescence
KW - Adolescence
KW - Agriculture
KW - Child
KW - Demography
KW - Epidemiological Research
KW - Farmworkers
KW - Female
KW - Male
KW - Minority Groups
KW - Occupational-Related Injuries -- Epidemiology
KW - Occupational-Related Injuries -- Risk Factors
KW - Sex Factors
KW - Surveys
KW - Wounds and Injuries -- Risk Factors
KW - Human
SP - 61
EP - 69
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 11
IS - 3/4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In 2000, there were an estimated 7,381 youth living on 9,556 U.S. farms operated by Native Americans. Most of these youth (5,454, 74%) lived on livestock operations (6,833 farms, 72%). In that year, youth living on Native American operated farms sustained an estimated 177 nonfatal injuries. The majority of all injuries to household youth (147, 83%) occurred on livestock operations. Males accounted for 112 (63%) of the injuries to household youth. Overall, household youth on Native American operated farms had an injury rate of 24.0 injuries per 1,000 household youth compared to a rate of 8.1 injuries per 1,000 household youth on all other minorityoperated farms. The rate ratio for work-related injuries to household youth on Native American farms compared to other minority-operated farms was 2.1. Although female youth on these farms experienced a similar non-work injury rate of 13.8 injuries per 1,000 female household youth compared to a rate of 15.1 injuries per 1,000 male household youth, the work-related injury rate for male youth (30.2 per 1,000 male household youth) was substantially higher than the work-related injury rate for female household youth (18.3 per 1,000 female household youth). These data indicate an elevated risk of injury for youth living on farms operated by Native Americans. This result is attributed to the large percentage of livestock operations for this population and the hazards associated with this type of farming. However, further research is needed to more fully understand these results and to guide culturally appropriate interventions within this population.
SN - 1059-924X
AD - Epidemiologist, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 1808, Morgantown, WV 26505
U2 - PMID: 19274898.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Niemtzow, Richard C.
AU - Gambel, Jeffrey
AU - Helms, Joseph
AU - Pock, Arnyce
AU - Burns, Stephen
AU - Baxter, John
T1 - Integrating Ear and Scalp Acupuncture Techniques into the Care of Blast-Injured United States Military Service Members with Limb Loss.
JO - Journal of Alternative & Complementary Medicine
JF - Journal of Alternative & Complementary Medicine
Y1 - 2006/09//
VL - 12
IS - 7
M3 - Article
SP - 596
EP - 599
PB - Mary Ann Liebert, Inc.
SN - 10755535
AB - A photo essay which documents ear and scalp acupuncture techniques into the care of blast-injured United States military service members with limb loss is presented.
KW - ACUPUNCTURE
KW - MILITARY departments & divisions -- United States
N1 - Accession Number: 22332790; Niemtzow, Richard C. 1; Email Address: n5ev@aol.com Gambel, Jeffrey 2 Helms, Joseph 3 Pock, Arnyce 4 Burns, Stephen 1 Baxter, John 5; Affiliation: 1: Acupuncture Clinic, Malcolm Grow Medical Center, Andrews Air Force Base, MD. 2: Physical Medicine & Rehabilitation Service, Walter Reed Army Medical Center, Washington, DC. 3: Helms Medical Institute, Stanford University School of Medicine, Berkeley, CA. 4: USAF Medical Corps, Office of the Surgeon General, Bolling Air Force Base, Washington, DC. 5: Pentagon Flight Medicine Clinic, Pentagon, Washington, DC.; Source Info: Sep2006, Vol. 12 Issue 7, p596; Subject Term: ACUPUNCTURE; Subject Term: MILITARY departments & divisions -- United States; Number of Pages: 4p; Document Type: Article
L3 - 10.1089/acm.2006.12.596
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22332790&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grant, Michael. A.
AU - Wernberg, Janes S.
AU - Van, Khanh T.
AU - Albert, Angelian M.
T1 - Two Rapid Methods for Detection of Escherichia coli Exceeding 104/g Action Levels: Precollaborative Study.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/09//Sep/Oct2006
VL - 89
IS - 5
M3 - Article
SP - 1317
EP - 1326
SN - 10603271
AB - The article compares two membrane filtration-based methods to the most probable number reference method for the detection of high levels of Escherichia coli in five types. The two proposed methods allow completion of both presumptive and confirmatory steps within in three days while the reference method requires as many as 11 days.
KW - ESCHERICHIA coli
KW - FOOD contamination
KW - FOOD -- Analysis
KW - MEMBRANE separation
KW - SANITARY chemistry
KW - ANALYTICAL chemistry
N1 - Accession Number: 22672312; Grant, Michael. A. 1; Email Address: rnike.grant@fda.hhs.gov Wernberg, Janes S. 2 Van, Khanh T. 2 Albert, Angelian M. 2; Affiliation: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory, Northwest, Bothell, WA 98021 2: U.S. Food and Drug Administration, Pacific Regional Laboratory, Southwest, Irvine, CA 92612; Source Info: Sep/Oct2006, Vol. 89 Issue 5, p1317; Subject Term: ESCHERICHIA coli; Subject Term: FOOD contamination; Subject Term: FOOD -- Analysis; Subject Term: MEMBRANE separation; Subject Term: SANITARY chemistry; Subject Term: ANALYTICAL chemistry; Number of Pages: 10p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nyman, Patricia J.
AU - Morehouse, Kim M.
AU - McNeal, Timothy P.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Single-Laboratory Validation of a Method for the Determination of Furan in Foods by Using Static Headspace Sampling and Gas Chromatography/Mass Spectrometry.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/09//Sep/Oct2006
VL - 89
IS - 5
M3 - Article
SP - 1417
EP - 1424
SN - 10603271
AB - The article describes a headspace gas chromatography/mass spectrometry method developed and validated in-house for the determination of furan in foods. The validation study demonstrated that the performance of the method in the analyses of simple and complex foods and showed that the method will reliably quantitate and confirm furan in a variety of foods at ng/g levels.
KW - FURANS
KW - FOOD -- Analysis
KW - GAS chromatography
KW - MASS spectrometry
KW - TECHNICAL chemistry
KW - ANALYTICAL chemistry
N1 - Accession Number: 22672324; Nyman, Patricia J. 1; Email Address: patricia.nyman@fda.hha.gov Morehouse, Kim M. 1 McNeal, Timothy P. 1 Perfetti, Gracia A. 1 Diachenko, Gregory W. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-245, 5100 Pain Branch Pkwy, College Park, MD 20740; Source Info: Sep/Oct2006, Vol. 89 Issue 5, p1417; Subject Term: FURANS; Subject Term: FOOD -- Analysis; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: TECHNICAL chemistry; Subject Term: ANALYTICAL chemistry; Number of Pages: 8p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kordzakhia, George
AU - Lalley, Steven P.
T1 - ERGODICITY AND MIXING PROPERTIES OF THE NORTHEAST MODEL.
JO - Journal of Applied Probability
JF - Journal of Applied Probability
Y1 - 2006/09//
VL - 43
IS - 3
M3 - Article
SP - 782
EP - 792
SN - 00219002
AB - The northeast model is a spin system on the two-dimensional integer lattice that evolves according to the following rule: whenever a site's southerly and westerly nearest neighbors have spin 1, it may reset its own spin by tossing a p-coin; at all other times, its spin remains frozen. It is proved that the northeast model has a phase transition at pc = 1 - βc, where βc is the critical parameter for oriented percolation. For p < pc, the trivial measure, δ0, that puts mass one on the configuration with all spins set at 0 is the unique ergodic, translation-invariant, stationary measure. For p ≥ pc, the product Bernoulli-p measure on configuration space is the unique nontrivial, ergodic, translation- invariant, stationary measure for the system, and it is mixing. For p > 2/3, it is shown that there is exponential decay of correlations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Probability is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERGODIC theory
KW - TRANSFORMATIONS (Mathematics)
KW - MATHEMATICAL physics
KW - PERCOLATION (Statistical physics)
KW - LATTICE theory
KW - exponential mixing
KW - facilitated spin-flip system
KW - Northeast model
KW - oriented percolation
N1 - Accession Number: 23576216; Kordzakhia, George 1; Email Address: kordzakh@stat.berkeley.edu; Lalley, Steven P. 2; Email Address: lalley@galton.uchicago.edu; Affiliations: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Biometrics I, Building 22, Room 4235, 10903 New Hampshire Avenue, USA; 2: Department of Statistics, University of Chicago, 5734 University Avenue, Chicago, IL 60637, USA; Issue Info: Sep2006, Vol. 43 Issue 3, p782; Subject Term: ERGODIC theory; Subject Term: TRANSFORMATIONS (Mathematics); Subject Term: MATHEMATICAL physics; Subject Term: PERCOLATION (Statistical physics); Subject Term: LATTICE theory; Author-Supplied Keyword: exponential mixing; Author-Supplied Keyword: facilitated spin-flip system; Author-Supplied Keyword: Northeast model; Author-Supplied Keyword: oriented percolation; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Steenbergen, Susan M.
AU - Young-Choon Lee
AU - Vann, Willie F.
AU - Vionnet, Justine
AU - Wright, Lori F.
AU - Vimr, Eric R.
T1 - Separate Pathways for O Acetylation of Polymeric and Monomeric Sialic Acids and Identification of Sialyl O-Acetyl Esterase in Escherichia coli K1.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2006/09//
VL - 188
IS - 17
M3 - Article
SP - 30
EP - 30
SN - 00219193
AB - O acetylation at carbon positions 7 or 9 of the sialic acid residues in the polysialic acid capsule of Escherichia coli K1 is catalyzed by a phase-variable contingency locus, neuO, carried by the K1-specific prophage, CUS-3. Here we describe a novel method for analyzing polymeric sialic acid O acetylation that involves the release of surface sialic acids by endo-N-acetylneuraminidase digestion, followed by fluorescent labeling and detection of quinoxalinone derivatives by chromatography. The results indicated that NeuO is responsible for the majority of capsule modification that takes place in vivo. However, a minor neuO-independent O acetylation pathway was detected that is dependent on the bifunctional polypeptide encoded by neuD. This pathway involves O acetylation of monomeric sialic acid and is regulated by another bifunctional enzyme, NeuA, which includes N-terminal synthetase and C-terminal sialyl O-esterase domains. A homologue of the NeuA C-terminal domain (Pm1710) in Pasteurella multocida was also shown to be an esterase, suggesting that it functions in the catabolism of acetylated environmental sialic acids. Our combined results indicate a previously unexpected complexity in the synthesis and catabolism of microbial sialic and polysialic acids. These findings are key to understanding the biological functions of modified sialic acids in E. coli K1 and other species and may provide new targets for drug or vaccine development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANNOSE
KW - ESCHERICHIA coli
KW - ACETYLATION
KW - ENTEROBACTERIACEAE
KW - CHROMATOGRAPHIC analysis
KW - PASTEURELLA multocida
KW - CARBON
N1 - Accession Number: 22292774; Steenbergen, Susan M. 1 Young-Choon Lee 1,2 Vann, Willie F. 3 Vionnet, Justine 3 Wright, Lori F. 4 Vimr, Eric R. 1; Email Address: ervimr@uiuc.edu; Affiliation: 1: Laboratory of Sialobiology and Comparative Metabolomics, Department of Pathobiology, University of Illinois, Urbana-Champaign, Urbana, Illinois 2: Department of Biotechnology, Dong-A University, Busan, South Korea 3: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 4: Department of Microbiology and Immunology, University of Rochester, Rochester, New York; Source Info: Sep2006, Vol. 188 Issue 17, p30; Subject Term: MANNOSE; Subject Term: ESCHERICHIA coli; Subject Term: ACETYLATION; Subject Term: ENTEROBACTERIACEAE; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PASTEURELLA multocida; Subject Term: CARBON; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.00466-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106184723
T1 - Visual assessment of angular response in medical liquid crystal displays.
AU - Badano A
AU - Schneider S
AU - Samei E
Y1 - 2006/09//
N1 - Accession Number: 106184723. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Computer/Information Science; Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9100529.
KW - Data Display
KW - Visual Perception
KW - Observer Bias
KW - Photometry
KW - Predictive Value of Tests
KW - Radiographic Image Enhancement
KW - Reproducibility of Results
KW - Task Performance and Analysis
KW - Technology, Radiologic
KW - Human
SP - 240
EP - 248
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
JA - J DIGIT IMAGING
VL - 19
IS - 3
CY - ,
PB - Springer Science & Business Media B.V.
AB - In spite of having non-Lambertian emission, displays based on liquid crystal technology are becoming popular for medical diagnostic work stations. For all liquid crystal displays (LCDs), the contrast performance varies with viewing direction. Accurate measurements of the angular distribution of light emission require expensive instrumentation and extensive expertise. We investigated the possibility of using a test pattern to visually assess the angular response performance of LCDs. We found that this procedure offers the end user of displays a simple, fast, and relatively consistent technique to verify that the viewing angle performance of the display device is within certain acceptable limits.
SN - 0897-1889
AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, 12720 Twinbrook Parkway, Rockville, MD 20857, USA. aldo.badano@fda.hhs.gov
U2 - PMID: 16741662.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dubaniewicz, Thomas H.
T1 - Methane–air mixtures ignited by CW laser-heated targets on optical fiber tips: Comparison of targets, optical fibers, and ignition delays
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2006/09//
VL - 19
IS - 5
M3 - Article
SP - 425
EP - 432
SN - 09504230
AB - Abstract: Fiber optic systems are being deployed in locations where explosive gas atmospheres are normally present or are present under fault conditions. The National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory (NIOSH, PRL) conducted a study of laser safety in potentially flammable environments. Researchers conducted experiments to estimate the mean and standard deviation of laser powers needed to ignite 6% methane–air atmospheres using single mode optical fiber tips covered by two types of iron oxide (Fe3O4 and (FeMn)2O3) mixed with a ceramic adhesive. The iron oxides, heated by a 1064nm continuous wave laser, ignited the methane–air mixtures at similar powers. The minimum igniting power and maximum non-igniting power (10 tests) were 407 and 350mW, respectively, using a 62.5μm fiber. Laser beams guided by 125 and 80μm diameter cladding single mode fibers produced similar methane–air igniting powers. Ignition was not observed using coal particles at powers that produced ignition with the iron oxides. Threshold ignition delays using the single mode fiber were approximately proportional to the inverse square of the igniting power. Ignition delays were significantly longer than the reported activation time for a commercial fiber optic power limiter. Comparisons are made with the results of other researchers. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBER optics
KW - INTEGRATED optics
KW - OPTICAL fibers
KW - LASERS
KW - Fiber optic power limiter
KW - Methane ignition
KW - Non-beam hazards
N1 - Accession Number: 21624345; Dubaniewicz, Thomas H. 1; Email Address: tcd5@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Sep2006, Vol. 19 Issue 5, p425; Thesaurus Term: FIBER optics; Subject Term: INTEGRATED optics; Subject Term: OPTICAL fibers; Subject Term: LASERS; Author-Supplied Keyword: Fiber optic power limiter; Author-Supplied Keyword: Methane ignition; Author-Supplied Keyword: Non-beam hazards; NAICS/Industry Codes: 327214 Glass manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jlp.2005.10.004
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Nemhauser, Jeff
AU - Osterloh, John
AU - Schier, Joshua G.
T1 - Medical Toxicology and Public Health--Update on Research and Activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry.
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
Y1 - 2006/09//
VL - 2
IS - 3
M3 - Article
SP - 114
EP - 115
SN - 15569039
AB - Provides an overview of the research and activities of different branches of the U.S. Centers for Disease Control and Prevention Agency for Toxic Substances and Disease Registry and the National Center for Environmental Health. Radiation Studies Branch; Health Studies Branch; Division of Laboratory Sciences.
KW - MEDICAL research
KW - PUBLIC health
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - NATIONAL Center for Environmental Health (U.S.)
N1 - Accession Number: 21760668; Nemhauser, Jeff 1,2 Osterloh, John 3 Schier, Joshua G. 2,4; Affiliation: 1: Commander, U.S. Public Health Service 2: Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention 3: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention 4: Lieutenant Commander, U.S. Public Health Service; Source Info: Sep2006, Vol. 2 Issue 3, p114; Subject Term: MEDICAL research; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: NATIONAL Center for Environmental Health (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106210924
T1 - Comparison of performance of three different types of respiratory protection devices.
AU - Lawrence RB
AU - Duling MG
AU - Calvert CA
AU - Coffey CC
Y1 - 2006/09//
N1 - Accession Number: 106210924. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; research; tables/charts. Note: For CE see Suppl pages D91-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Respiratory Protective Devices -- Evaluation
KW - Adult
KW - Comparative Studies
KW - Education, Continuing (Credit)
KW - Female
KW - Fisher's Exact Test
KW - Male
KW - Middle Age
KW - Human
SP - 465
EP - 474
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Respiratory protection is offered to American workers in a variety of ways to guard against potential inhalation hazards. Two of the most common ways are elastomeric N95 respirators and N95 filtering-facepiece respirators. Some in the health care industry feel that surgical masks provide an acceptable level of protection in certain situations against particular hazards. This study compared the performance of these types of respiratory protection during a simulated workplace test that measured both filter penetration and face-seal leakage. A panel of 25 test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020, and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. The results of these tests produced a simulated workplace protection factor (SWPF). The geometric mean (GM) and the 5th percentile values of the SWPFs were computed by category of respiratory protection using the six overall SWPF values. The level of protection provided by each of the three respiratory protection types was compared. The GM and 5th percentile SWPF values without fit testing were used for the comparison, as surgical masks were not intended to be fit tested. The GM values were 36 for elastomeric N95 respirators, 21 for N95 filtering-facepiece respirators, and 3 for surgical masks. An analysis of variance demonstrated a statistically significant difference between all three. Elastomeric N95 respirators had the highest 5th percentile SWPF of 7. N95 filtering-facepiece respirators and surgical masks had 5th percentile SWPFs of 3 and 1, respectively. A Fisher Exact Test revealed that the 5th percentile SWPFs for all three types of respiratory protection were statistically different. In addition, both qualitative (Bitrex and saccharin) and quantitative (N95-Companion) fit testing were performed on the N95 filtering- and elastomeric-facepiece respirators. It was found that passing a fit test generally improves the protection afforded the wearer. Passing the Bitrex fit test resulted in 5th percentile SWPFs of 11.1 and 7.9 for elastomeric and filtering-facepiece respirators, respectively. After passing the saccharin tests, the elastomeric respirators provided a 5th percentile of 11.7, and the filtering-facepiece respirators provided a 5th percentile of 11.0. The 5th percentiles after passing the N95-Companion were 13.0 for the elastomeric respirators and 20.5 for the filtering-facepiece respirators. The data supports fit testing as an essential element of a complete respiratory protection program.
SN - 1545-9624
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; rbl2@cdc.gov
U2 - PMID: 16857645.
DO - 10.1080/15459620600829211
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Changning Guo
AU - Doub, William H.
T1 - The influence of actuation parameters on in vitro testing of nasal spray products.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/09//
VL - 95
IS - 9
M3 - Article
SP - 2029
EP - 2040
SN - 00223549
AB - Nasal spray drug products are normally characterized via measurement of shot weight, spray pattern, plume geometry, and droplet size distribution (DSD). In this project, the actuation parameters, such as stroke length, actuation velocity, and actuation acceleration, were investigated to ascertain how they affect nasal spray characteristics. Pfeiffer nasal spray pump units filled with water were used in the study. Actuation parameters were adjusted using an electronic automated actuation system, SprayVIEW™ NSx. Spray pattern and plume geometry measurements were carried out using a high speed optical spray characterization system, SprayVIEW™ NSP, and DSD analysis was performed using a Malvern 2600 laser diffraction system. Our results show that different actuation parameters affect the nasal spray characteristics in different ways and to different degrees. Among all the actuation parameters, stroke length and actuation velocity have significant effects on the nasal spray characteristics, while the other actuation parameters have little, if any, effect. Compared to spray pattern, plume geometry and DSD, shot weight provides very little characterization information. The findings from this work suggest that, for in vitro bioavailability (BA) and bioequivalence (BE) studies of nasal spray products, the actuation parameters, stroke length, and velocity must be carefully selected. Spray pattern, plume geometry, and DSD appear to provide critical data for assessment of nasal pump performance. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 2029–2040, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOAVAILABILITY
KW - ASSOCIATIONS, institutions, etc.
KW - PHARMACISTS
KW - DRUGS
KW - MEDICAL personnel
KW - BIOCHEMISTRY
KW - automated actuation
KW - droplet size distribution
KW - in vitro test
KW - laser diffraction
KW - nasal drug delivery
KW - plume geometry
KW - spray pattern
KW - SprayVIEW™
KW - SprayVIEW™
N1 - Accession Number: 21786408; Changning Guo 1; Email Address: changning.guo@fda.hhs.gov Doub, William H. 1; Affiliation: 1: Division of Pharmaceutical Analysis, U. S. Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, Missouri 63101; Source Info: Sep2006, Vol. 95 Issue 9, p2029; Subject Term: BIOAVAILABILITY; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: PHARMACISTS; Subject Term: DRUGS; Subject Term: MEDICAL personnel; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: automated actuation; Author-Supplied Keyword: droplet size distribution; Author-Supplied Keyword: in vitro test; Author-Supplied Keyword: laser diffraction; Author-Supplied Keyword: nasal drug delivery; Author-Supplied Keyword: plume geometry; Author-Supplied Keyword: spray pattern; Author-Supplied Keyword: SprayVIEW™; Author-Supplied Keyword: SprayVIEW™; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 12p; Illustrations: 1 Black and White Photograph, 1 Chart, 9 Graphs; Document Type: Article
L3 - 10.1002/jps.20678
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Zmudzka, Barbara Z.
AU - Hearing, Vincent J.
AU - Beer, Janusz Z.
T1 - Photobiologic role of melanin distribution in the epidermis
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2006/09//
VL - 84
IS - 3
M3 - Letter
SP - 231
EP - 231
SN - 10111344
N1 - Accession Number: 21920283; Zmudzka, Barbara Z. 1; Email Address: barbara.zmudzka@fda.hhs.gov Hearing, Vincent J. 2 Beer, Janusz Z. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852, USA 2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Sep2006, Vol. 84 Issue 3, p231; Number of Pages: 1p; Document Type: Letter
L3 - 10.1016/j.jphotobiol.2006.05.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106364999
T1 - Interdisciplinary research: the role of nursing education.
AU - Hubbard HB
Y1 - 2006/09//
N1 - Accession Number: 106364999. Language: English. Entry Date: 20061124. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - Education, Nursing
KW - Health Services Research
KW - Research, Interdisciplinary
SP - 266
EP - 269
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 22
IS - 5
CY - Philadelphia, Pennsylvania
PB - W B Saunders
SN - 8755-7223
AD - Senior Advisor for Patient Safety Regulation, Center for Quality Improvement and Patient Safety Agency for Healthcare Research and Quality (AHRQ), Rockville, MD
U2 - PMID: 16990117.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106364999&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106281628
T1 - Waste incineration -- how big is the health risk? A quantitative method to allow comparison with other health risks.
AU - Roberts RJ
AU - Chen M
Y1 - 2006/09//
N1 - Accession Number: 106281628. Language: English. Entry Date: 20070511. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 101188638.
KW - Air Pollution -- Adverse Effects
KW - Environmental Exposure -- Adverse Effects
KW - Hazardous Materials -- Adverse Effects
KW - Refuse Disposal
KW - Risk Assessment
KW - Air Pollutants
KW - Carcinogens
KW - Dioxins
KW - Prospective Studies
KW - Sample Size
KW - Wales
KW - Human
SP - 261
EP - 266
JO - Journal of Public Health
JF - Journal of Public Health
JA - J PUBLIC HEALTH
VL - 28
IS - 3
PB - Oxford University Press / USA
AB - OBJECTIVE: To assess the health risk from a medium-sized waste incinerator and develop a single comparable figure to quantify overall risk. METHOD: We used a prospective health risk assessment utilizing US Environmental Protection Agency Human Health Risk Assessment Protocol (HHRAP) for Hazardous Waste Combustion Facilities and UK coefficients for the impact of sulphur dioxide and particulates. Calculations were based on a resident population of 25,398 living within 5.5 km of the site. RESULTS: Anxiety, employment, noise, occupational risks, road accidents, and reduced use of landfill were all considered to have a potential, but unquantifiable, effect on health. Stack emissions over 25 years in a population of 25,398 within 5.5 km of the stack would result in an additional 0.018 cancers, 0.46 deaths brought forward due to sulphur dioxide and 0.02 deaths due to fine particles. The overall risk of dying due to emissions in any one year was 2.49 x 10(-7) or 1 in 4 million. CONCLUSION: To facilitate better public understanding of the comparative risk of incinerator emissions, we propose a simple method of deriving a single annual risk figure allowing comparison with the risk of dying from other causes with which the public is more familiar.
SN - 1741-3842
AD - National Public Health Service for Wales, Abton House, Wedal Road, Cardiff, CF14 3QX, UK.
U2 - PMID: 16868310.
DO - pubmed/fdl037
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thompson, Douglas R.
AU - Iachan, Ronaldo
AU - Overpeck, Mary
AU - Ross, James G.
AU - Gross, Lori A.
T1 - School Connectedness in the Health Behavior in School-Aged Children Study: The Role of Student, School, and School Neighborhood Characteristics.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2006/09//
VL - 76
IS - 7
M3 - Article
SP - 379
EP - 386
PB - Wiley-Blackwell
SN - 00224391
AB - School connectedness includes liking school and positive relations with teachers and peers. School connectedness is associated with a variety of positive health outcomes. The goal of this study was to identify characteristics of students, schools, and school neighborhoods that are related to school connectedness. In the Health Behavior in School-Aged Children (HBSC) Study, school connectedness was reported by 13,207 students (grades 6-10) in 340 schools. HBSC measured a variety of student characteristics. Characteristics of schools were culled from data maintained by Quality Education Data, and school neighborhood characteristics were derived from the 2000 decennial census. Associations between connectedness and student, school, and school neighborhood characteristics were estimated using hierarchical linear models. Characteristics of students, schools, and school neighborhoods were associated with school connectedness. Connectedness was greater among younger students, females, students with better academic performance and greater extracurricular involvement, students with greater self-rated physical attractiveness, students with more friends, students from 2-parent families, and students whose parents were more involved with school. Connectedness was greater in smaller schools, more racially homogeneous schools, and schools with more students from relatively wealthy households. School connectedness was higher in neighborhoods with a greater percentage of non-US citizens. As the percent of renters in the neighborhood increased beyond 20%, school connectedness tended to decrease. The findings point to possible strategies for fostering school connectedness. (J Sch Health. 2006;76(7):379-386) [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of School Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH behavior in children
KW - ATTITUDES toward health
KW - SOCIAL groups
KW - NEIGHBORHOODS
KW - CHILDREN -- Health
KW - LINEAR models (Statistics)
KW - CHILD psychology
KW - SCHOOL environment
KW - SOCIAL aspects
N1 - Accession Number: 22019289; Thompson, Douglas R. 1; Email Address: dthompson@mmri.org Iachan, Ronaldo 2; Email Address: ronaldo.iachan@orcmacro.com Overpeck, Mary 3; Email Address: overpecm@hrsa.gov Ross, James G. 4; Email Address: james.g.ross@orcmacro.com Gross, Lori A. 5; Email Address: lori.gross@orcmacro.com; Affiliation: 1: Senior Research Scientist Maryland Medical Research Institute, 600 Wyndhurst Ave, Baltimore, MD 21210 2: Senior Statistician ORC Macro, 11785 Beltsville Drive, Calverton, MD 20705 3: Epidemiologist Health Resources and Services Administration, HRSA/MCHB Office of Data and Program Development, 5600 Fishers Lane room 18-41, Rockville, MD 20857 4: Senior Vice President ORC Macro, 11785 Beltsville Drive, Calverton, MD 20705 5: Project Manager ORC Macro, 11785 Beltsville Drive, Calverton, MD 20705; Source Info: Sep2006, Vol. 76 Issue 7, p379; Subject Term: HEALTH behavior in children; Subject Term: ATTITUDES toward health; Subject Term: SOCIAL groups; Subject Term: NEIGHBORHOODS; Subject Term: CHILDREN -- Health; Subject Term: LINEAR models (Statistics); Subject Term: CHILD psychology; Subject Term: SCHOOL environment; Subject Term: SOCIAL aspects; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 5401
L3 - 10.1111/j.1746-1561.2006.00129.x
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Barr, Dana Boyd
AU - Barr, John R.
AU - Calafat, Antonia M.
AU - Needliam, Larry L.
AU - Rubin, Carol
AU - Joskow, Renée
T1 - Authors' response.
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2006/09//
VL - 137
IS - 9
M3 - Letter
SP - 1214
EP - 1214
SN - 00028177
AB - A response by Dana Boyd Barr, John R. Barr, and Antonia M. Calafar to a letter to the editor about their article "Exposure to Bisphenol A From Bis-glycidyl Dimethacrylate-based Dental Sealants," in the March 2006 issue is presented.
KW - LETTERS to the editor
KW - SEALING compounds
N1 - Accession Number: 22447374; Barr, Dana Boyd 1 Barr, John R. 2 Calafat, Antonia M. 3 Needliam, Larry L. 4 Rubin, Carol 5 Joskow, Renée 6,7; Affiliation: 1: Chief, Pesticide Laboratory, Centers for Disease Control and Prevention National Center for Environmental Health, Atlanta 2: Chief, Biological Mass Spectrometry Laboratory, Centers for Disease Control and Prevention National Center for Environmental Health, Atlanta 3: Chief, Personal Care Products Laboratory, Centers for Disease Control and Prevention National Center for Environmental Health, Atlanta 4: Chief, Organic Analytical Toxicology, Branch Division of Laboratory Sciences, Centers for Disease Control and Prevention National Center for Environmental Health, Atlanta 5: Chief, Health Studies Branch Division of Environmental Health and Hazard Evaluation, Centers for Disease Control and Prevention National Center for Environmental Health, Atlanta 6: Commander U.S. Public Health Service Office of Force Readiness, Rockville, Md. 7: Deployment Office of the Surgeon General Office of the Secretary U.S. Department of Health and Human Services, Rockville, Md.; Source Info: Sep2006, Vol. 137 Issue 9, p1214; Subject Term: LETTERS to the editor; Subject Term: SEALING compounds; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325520 Adhesive Manufacturing; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carmona, Richard H.
T1 - Dietitians Play Important Role in Emergency Preparedness
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/09//
VL - 106
IS - 9
M3 - Article
SP - 1321
EP - 1321
SN - 00028223
N1 - Accession Number: 22371043; Carmona, Richard H. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Sep2006, Vol. 106 Issue 9, p1321; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.jada.2006.06.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22371043&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106212183
T1 - From the Surgeon General. Dietitians play important role in emergency preparedness.
AU - Carmona RH
Y1 - 2006/09//
N1 - Accession Number: 106212183. Language: English. Entry Date: 20070112. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Dietitians
KW - Disaster Planning
KW - Emergency Medical Services
KW - Public Health
KW - Natural Disasters
KW - Terrorism
KW - United States
SP - 1321
EP - 1321
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
U2 - PMID: 16963329.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106212183&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sergeev, Nikolay
AU - Rubtcova, Elena
AU - Chizikov, Vladimir
AU - Schmid, D. Scott
AU - Loparev, Vladimir N.
T1 - New mosaic subgenotype of varicella-zoster virus in the USA: VZV detection and genotyping by oligonucleotide-microarray
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/09//
VL - 136
IS - 1/2
M3 - Article
SP - 8
EP - 16
SN - 01660934
AB - Abstract: A rapid and sensitive microarray-based method was used to distinguish the three major circulating genotypes of varicella-zoster virus (VZV). The method analyzes five variable positions located in a 447-nucleotide variable region 1 of open reading frame 22 (ORF 22r1); these single nucleotide polymorphisms (SNP) display in stably occurring patterns specific to each of the VZV genotypes established in previously published studies. Pairs of short oligonucleotide probes (oligoprobes) with sequences corresponding to all of the observed SNP were used to detect specific sequences. Fluorescently labeled ssRNA samples for hybridization with a chip were prepared by in vitro T7 polymerase driven transcription of the amplicons of ORF 22r1, followed by chemical labeling with Cy5 into RNA sample. Ratios between fluorescent hybridization signals from each pair of oligoprobes were used to assess the sequence at each SNP. We evaluated six reference VZV strains and 130 VZV clinical specimens to validate the method. The microarray method accurately identified strains isolated in the US in 2001–2002, representing all major genotypes as determined using more extensive sequence analysis, correctly assigning strains to genotypes E (81.5%), J (3%) and M (15.5%). In addition, a new M variant (M3) was identified. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VARICELLA-zoster virus
KW - GENETIC polymorphisms
KW - RNA
KW - CHICKENPOX
KW - Genotyping
KW - Microarray
KW - Oligonucleotide
KW - Varicella-zoster virus
N1 - Accession Number: 21663864; Sergeev, Nikolay 1 Rubtcova, Elena 2 Chizikov, Vladimir 3 Schmid, D. Scott 2; Email Address: dss1@cdc.gov Loparev, Vladimir N. 2; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Technology, Division of Life Sciences, Silver Spring, MD 20993, USA 2: Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Measles and Herpesvirus Team, National VZV Laboratory, 1600 Clifton Road, MS G-18, Atlanta, GA 30333, USA 3: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Viral Products, Silver Spring, MD 20993, USA; Source Info: Sep2006, Vol. 136 Issue 1/2, p8; Subject Term: VARICELLA-zoster virus; Subject Term: GENETIC polymorphisms; Subject Term: RNA; Subject Term: CHICKENPOX; Author-Supplied Keyword: Genotyping; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Oligonucleotide; Author-Supplied Keyword: Varicella-zoster virus; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.03.021
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21663864&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Swan, David C.
AU - Limor, Josef R.
AU - Duncan, Kara L.
AU - Rajeevan, Mangalathu S.
AU - Unger, Elizabeth R.
T1 - Human papillomavirus type 16 variant assignment by pyrosequencing
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/09//
VL - 136
IS - 1/2
M3 - Article
SP - 166
EP - 170
SN - 01660934
AB - Abstract: Polymorphisms in human papillomavirus type 16 (HPV16) result in variants from the prototype sequence which can be designated according to geographic distribution and are broadly classified as European (E), African (Af), Asian (As), or Asian-American (AA). Detection of variants has been used to distinguish persistent HPV16 infection from re-infection in natural history studies, and variants have been associated with an increased risk of cervical disease in some populations. Variant determination usually relies on conventional Sanger sequencing of regions of the viral genome, with the major variant group assignments requiring the sequencing of only seven polymorphic sites spread over a 242-bp region of the E6 gene. We applied pyrosequencing to facilitate rapid sequencing and enable the simultaneous detection of multiple variants. A single-stranded template for pyrosequencing was prepared by amplifying a 314-bp fragment (nt 75-388) with a biotin at the 5′-end of the reverse primer to facilitate strand separation and purification. Polymorphisms at the nucleotide sites 109, 131, 132, 143, 145, 178 and 350 were determined in three separate sequencing reactions, one of which was a multiplex format. Pyrosequencing of 97 HPV16-positive exfoliated cervical samples confirmed the Sanger sequencing results; however pyrosequencing identified additional variants in several samples containing mixed variants. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAPILLOMAVIRUSES
KW - GENETICS
KW - VITAMIN B complex
KW - GENOMES
KW - E6
KW - HPV16
KW - Pyrosequencing
KW - Variants
N1 - Accession Number: 21663884; Swan, David C. 1; Email Address: dswan@cdc.gov Limor, Josef R. 2 Duncan, Kara L. 1 Rajeevan, Mangalathu S. 1 Unger, Elizabeth R. 1; Affiliation: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, United States 2: Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, United States; Source Info: Sep2006, Vol. 136 Issue 1/2, p166; Subject Term: PAPILLOMAVIRUSES; Subject Term: GENETICS; Subject Term: VITAMIN B complex; Subject Term: GENOMES; Author-Supplied Keyword: E6; Author-Supplied Keyword: HPV16; Author-Supplied Keyword: Pyrosequencing; Author-Supplied Keyword: Variants; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.05.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bower, Kraig S.
AU - Donnelly, Steven J.
AU - Stutzman, Richard D.
AU - Ward, Thomas P.
AU - Weber, Eric
T1 - Acanthamoeba Keratitis in a U.S. Army Soldier after Unauthorized Use of Contact Lenses in the Combat Theater.
JO - Military Medicine
JF - Military Medicine
Y1 - 2006/09//
VL - 171
IS - 9
M3 - Article
SP - 833
EP - 837
PB - AMSUS
SN - 00264075
AB - A 25-year-old active duty Army E-5 developed severe infectious keratitis in his left eye secondary to soft contact lens (CL) wear while deployed in Iraq, necessitating evacuation to Walter Reed Army Medical Center for further evaluation and treatment, Initial clinical examination at Walter Reed Army Medical Center was suggestive of Acanthamoeba keratitis, a serious corneal pathogen associated with CL wear. In vivo confocal microscopy demonstrated Acanthamneba cysts in the epithelium and anterior stroma, and smears and cultures from an epithelial biopsy specimen confirmed the diagnosis of Acanthamoeba keratitis. To our knowledge this is the first reported case of Acanthamoeba keratitis in a soldier wearing CLs in the combat theater. Because of the inability to maintain proper lens hygiene in a combat or field environment, the risk of developing a potentially sight-threatening corneal infection is significant. This unfortunate case of a devastating eye infection serves as a reminder of the current Army policy, which prohibits the use of CLs during gas chamber exercises, field training, and combat. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KERATITIS
KW - EYE -- Diseases
KW - EYE -- Inflammation
KW - CONTACT lenses
KW - ACANTHAMOEBA
KW - PATHOGENIC microorganisms
KW - UNITED States. Army
N1 - Accession Number: 22465625; Bower, Kraig S. 1,2; Donnelly, Steven J. 1; Stutzman, Richard D. 1; Ward, Thomas P. 1,2,3; Weber, Eric 1; Source Information: Sep2006, Vol. 171 Issue 9, p833; Subject: KERATITIS; Subject: EYE -- Diseases; Subject: EYE -- Inflammation; Subject: CONTACT lenses; Subject: ACANTHAMOEBA; Subject: PATHOGENIC microorganisms; Subject: UNITED States. Army; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Casciano, Daniel A.
AU - Woodcock, Janet
T1 - Empowering microarrays in the regulatory setting.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1103
EP - 1103
SN - 10870156
AB - A foreword to "Nature Biotechnology," is presented.
KW - Prefaces & forewords
KW - DNA microarrays
N1 - Accession Number: 22286214; Casciano, Daniel A. 1; Email Address: dcasciano@sbcglobal.net; Woodcock, Janet 2; Affiliations: 1: Professor, University of Arkansas for Medical Sciences, Little Rock, 47 Marcella Drive, Little Rock, Arkansas 72223, USA; 2: Deputy Commissioner for Operations, US Food and Drug Administration, Rockville, Maryland 20857, USA; Issue Info: Sep2006, Vol. 24 Issue 9, p1103; Subject Term: Prefaces & forewords; Subject Term: DNA microarrays; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 1p; Document Type: Article
L3 - 10.1038/nbt0906-1103
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frueh, Felix W.
T1 - Impact of microarray data quality on genomic data submissions to the FDA.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1105
EP - 1107
SN - 10870156
AB - The article reports on the implications of microarray data quality on the submissions of genomic data to the U.S. Food and Drug Administration. The adoption and integration of genomic data in drug development is influenced by several factors including an understanding of the disease pathophysiology. Experts believed that microarray platforms, like the MicroArray Quality Consortium, are essential tools to make reliable data for drug development and regulatory decision making.
KW - Genomics
KW - Drug development
KW - Decision making
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 22286213; Frueh, Felix W. 1; Email Address: felix.frueh@fda.hhs.gov; Affiliations: 1: US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluationand Research, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA; Issue Info: Sep2006, Vol. 24 Issue 9, p1105; Subject Term: Genomics; Subject Term: Drug development; Subject Term: Decision making; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1038/nbt0906-1105
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Canales, Roger D.
AU - Yuling Luo
AU - Willey, James C.
AU - Austermiller, Bradley
AU - Barbacioru, Catalin C.
AU - Boysen, Cecilie
AU - Hunkapiller, Kathryn
AU - Jensen, Roderick V.
AU - Knight, Charles R.
AU - Lee, Kathleen Y.
AU - Yunqing Ma
AU - Maqsodi, Botoul
AU - Papallo, Adam
AU - Peters, Elizabeth Herness
AU - Poulter, Karen
AU - Ruppel, Patricia L.
AU - Samaha, Raymond R.
AU - Leming Shi
AU - Wen Yang
AU - Lu Zhang
T1 - Evaluation of DNA microarray results with quantitative gene expression platforms.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1115
EP - 1122
SN - 10870156
AB - We have evaluated the performance characteristics of three quantitative gene expression technologies and correlated their expression measurements to those of five commercial microarray platforms, based on the MicroArray Quality Control (MAQC) data set. The limit of detection, assay range, precision, accuracy and fold-change correlations were assessed for 997 TaqMan Gene Expression Assays, 205 Standardized RT (Sta)RT-PCR assays and 244 QuantiGene assays. TaqMan is a registered trademark of Roche Molecular Systems, Inc. We observed high correlation between quantitative gene expression values and microarray platform results and found few discordant measurements among all platforms. The main cause of variability was differences in probe sequence and thus target location. A second source of variability was the limited and variable sensitivity of the different microarray platforms for detecting weakly expressed genes, which affected interplatform and intersite reproducibility of differentially expressed genes. From this analysis, we conclude that the MAQC microarray data set has been validated by alternative quantitative gene expression platforms thus supporting the use of microarray platforms for the quantitative characterization of gene expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Hybridization
KW - DNA microarrays
KW - Gene expression
KW - Experimental genetics
KW - Roche Molecular Systems Inc.
N1 - Accession Number: 22286203; Canales, Roger D. 1; Yuling Luo 2; Willey, James C. 3; Austermiller, Bradley 3; Barbacioru, Catalin C. 1; Boysen, Cecilie 4; Hunkapiller, Kathryn 1; Jensen, Roderick V. 5; Knight, Charles R. 6; Lee, Kathleen Y. 1; Yunqing Ma 2; Maqsodi, Botoul 2; Papallo, Adam 5; Peters, Elizabeth Herness 6; Poulter, Karen 1; Ruppel, Patricia L. 7; Samaha, Raymond R. 1; Leming Shi 8; Wen Yang 2; Lu Zhang 1; Affiliations: 1: Applied Biosystems, 850 Lincoln Centre Dr., Foster City, California 94404, USA; 2: Panomics, Inc., 6519 Dumbarton Circle, Fremont, California 94555, USA; 3: University of Toledo, Toledo, Ohio 43614, USA; 4: ViaLogy Corp., 2400 Lincoln Avenue, Altadena, California 91001, USA; 5: University of Massachusetts-Boston, 100 Morrissey Blvd., Boston, Massachusetts 02125, USA; 6: Gene Express, Inc., 975 Research Drive, Toledo, Ohio 43614, USA; 7: Innovative Analytics, 7107 Elm Valley Dr., Kalamazoo, Michigan 49009, USA; 8: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; Issue Info: Sep2006, Vol. 24 Issue 9, p1115; Thesaurus Term: RNA; Thesaurus Term: Hybridization; Subject Term: DNA microarrays; Subject Term: Gene expression; Subject Term: Experimental genetics ; Company/Entity: Roche Molecular Systems Inc. DUNS Number: 883238743; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1038/nbt1236
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22286203&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shippy, Richard
AU - Fulmer-Smentek, Stephanie
AU - Jensen, Roderick V.
AU - Jones, Wendell D.
AU - Wolber, Paul K.
AU - Johnson, Charles D.
AU - Pine, P. Scott
AU - Boysen, Cecilie
AU - Xu Guo
AU - Chudin, Eugene
AU - Sun, Yongming Andrew
AU - Willey, James C.
AU - Thierry-Mieg, Jean
AU - Thierry-Mieg, Danielle
AU - Setterquist, Robert A.
AU - Wilson, Mike
AU - Lucas, Anne Bergstrom
AU - Novoradovskaya, Natalia
AU - Papallo, Adam
AU - Turpaz, Yaron
T1 - Using RNA sample titrations to assess microarray platform performance and normalization techniques.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1123
EP - 1131
SN - 10870156
AB - We have assessed the utility of RNA titration samples for evaluating microarray platform performance and the impact of different normalization methods on the results obtained. As part of the MicroArray Quality Control project, we investigated the performance of five commercial microarray platforms using two independent RNA samples and two titration mixtures of these samples. Focusing on 12,091 genes common across all platforms, we determined the ability of each platform to detect the correct titration response across the samples. Global deviations from the response predicted by the titration ratios were observed. These differences could be explained by variations in relative amounts of messenger RNA as a fraction of total RNA between the two independent samples. Overall, both the qualitative and quantitative correspondence across platforms was high. In summary, titration samples may be regarded as a valuable tool, not only for assessing microarray platform performance and different analysis methods, but also for determining some underlying biological features of the samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Messenger RNA
KW - Gene expression
KW - DNA microarrays
KW - Biochips
KW - Experimental genetics
KW - Volumetric analysis
N1 - Accession Number: 22286201; Shippy, Richard 1; Email Address: richard.shippy@ge.com; Fulmer-Smentek, Stephanie 2; Jensen, Roderick V. 3; Jones, Wendell D. 4; Wolber, Paul K. 2; Johnson, Charles D. 5; Pine, P. Scott 6; Boysen, Cecilie 7; Xu Guo 8; Chudin, Eugene 9; Sun, Yongming Andrew 10; Willey, James C. 11; Thierry-Mieg, Jean 12; Thierry-Mieg, Danielle 12; Setterquist, Robert A. 13; Wilson, Mike 5; Lucas, Anne Bergstrom 2; Novoradovskaya, Natalia 14; Papallo, Adam 3; Turpaz, Yaron 8; Affiliations: 1: GE Healthcare, 7700 S. River Pkwy., Suite #2603, Tempe, Arizona 85284, USA; 2: Agilent Technologies, Inc., 5301 Stevens Creek Blvd., Santa Clara, California 95051, USA; 3: University of Massachusetts-Boston, 100 Morrissey Blvd., Boston, Massachusetts 02125, USA; 4: Expression Analysis, Inc., 2605 Meridian Pkwy., Durham, North Carolina 27713, USA; 5: Asuragen, Inc., 2150 Woodward, Austin, Texas 78744, USA; 6: Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA; 7: ViaLogy, 2400 Lincoln Ave, Altadena, California 91001, USA; 8: Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, USA; 9: Illumina, Inc., 9885 Towne Centre Dr., San Diego, California 92121, USA; 10: Applied Biosystems, 850 Lincoln Centre Dr., Foster City, California 94404, USA; 11: University of Toledo, Toledo, Ohio 43606, USA; 12: National Center for Biotechnology Information, Bethesda, Maryland 20894, USA; 13: Applied Biosystems, 2150 Woodward, Austin, Texas 78744, USA; 14: Stratagene, 11011 N. Torrey Pines Rd., La Jolla, California 92037, USA; Issue Info: Sep2006, Vol. 24 Issue 9, p1123; Subject Term: Messenger RNA; Subject Term: Gene expression; Subject Term: DNA microarrays; Subject Term: Biochips; Subject Term: Experimental genetics; Subject Term: Volumetric analysis; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1038/nbt1241
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22286201&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weida Tong
AU - Lucas, Anne Bergstrom
AU - Shippy, Richard
AU - Xiaohui Fan
AU - Hong Fang
AU - Huixiao Hong
AU - Orr, Michael S.
AU - Tzu-Ming Chu
AU - Xu Guo
AU - Collins, Patrick J.
AU - Sun, Yongming Andrew
AU - Sue-Jane Wang
AU - Wenjun Bao
AU - Wolfinger, Russell D.
AU - Shchegrova, Svetlana
AU - Lei Guo
AU - Warrington, Janet A.
AU - Leming Shi
T1 - Evaluation of external RNA controls for the assessment of microarray performance.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1132
EP - 1139
SN - 10870156
AB - External RNA controls (ERCs), although important for microarray assay performance assessment, have yet to be fully implemented in the research community. As part of the MicroArray Quality Control (MAQC) study, two types of ERCs were implemented and evaluated; one was added to the total RNA in the samples before amplification and labeling; the other was added to the copyRNAs (cRNAs) before hybridization. ERC concentration-response curves were used across multiple commercial microarray platforms to identify problematic assays and potential sources of variation in the analytical process. In addition, the behavior of different ERC types was investigated, resulting in several important observations, such as the sample-dependent attributes of performance and the potential of using these control RNAs in a combinatorial fashion. This multiplatform investigation of the behavior and utility of ERCs provides a basis for articulating specific recommendations for their future use in evaluating assay performance across multiple platforms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Hybridization
KW - DNA microarrays
KW - Biochips
KW - Gene expression
KW - Experimental genetics
N1 - Accession Number: 22286202; Weida Tong 1; Email Address: weida.tong@fda.hhs.gov; Lucas, Anne Bergstrom 2; Shippy, Richard 3; Xiaohui Fan 1,4; Hong Fang 5; Huixiao Hong 5; Orr, Michael S. 6; Tzu-Ming Chu 7; Xu Guo 8; Collins, Patrick J. 2; Sun, Yongming Andrew 9; Sue-Jane Wang 6; Wenjun Bao 7; Wolfinger, Russell D. 7; Shchegrova, Svetlana 2; Lei Guo 1; Warrington, Janet A. 8; Leming Shi 1; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; 2: Agilent Technologies, Inc., 5301 Stevens Creek Blvd., Santa Clara, California 95051, USA; 3: GE Healthcare, 7700 S. River Pkwy., Suite #2603, Tempe, Arizona 85284, USA; 4: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310027, China; 5: Z-Tech Corporation, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; 6: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA; 7: SAS Institute Inc., SAS Campus Drive, Cary, North Carolina 27513, USA; 8: Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, USA; 9: Applied Biosystems, 850 Lincoln Centre Dr., Foster City, California 94404, USA; Issue Info: Sep2006, Vol. 24 Issue 9, p1132; Thesaurus Term: RNA; Thesaurus Term: Hybridization; Subject Term: DNA microarrays; Subject Term: Biochips; Subject Term: Gene expression; Subject Term: Experimental genetics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
L3 - 10.1038/nbt1237
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Patterson, Tucker A.
AU - Lobenhofer, Edward K.
AU - Fulmer-Smentek, Stephanie B.
AU - Collins, Patrick J.
AU - Tzu-Ming Chu
AU - Wenjun Bao
AU - Hong Fang
AU - Kawasaki, Ernest S.
AU - Hager, Janet
AU - Tikhonova, Irina R.
AU - Walker, Stephen J.
AU - Liang Zhang
AU - Hurban, Patrick
AU - de Longueville, Francoise
AU - Fuscoe, James C.
AU - Weida Tong
AU - Leming Shi
AU - Wolfinger, Russell D.
T1 - Performance comparison of one-color and two-color platforms within the Microarray Quality Control (MAQC) project.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/09//
VL - 24
IS - 9
M3 - Article
SP - 1140
EP - 1150
SN - 10870156
AB - Microarray-based expression profiling experiments typically use either a one-color or a two-color design to measure mRNA abundance. The validity of each approach has been amply demonstrated. Here we provide a simultaneous comparison of results from one- and two-color labeling designs, using two independent RNA samples from the Microarray Quality Control (MAQC) project, tested on each of three different microarray platforms. The data were evaluated in terms of reproducibility, specificity, sensitivity and accuracy to determine if the two approaches provide comparable results. For each of the three microarray platforms tested, the results show good agreement with high correlation coefficients and high concordance of differentially expressed gene lists within each platform. Cumulatively, these comparisons indicate that data quality is essentially equivalent between the one- and two-color approaches and strongly suggest that this variable need not be a primary factor in decisions regarding experimental microarray design. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hybridization
KW - Genetics
KW - Messenger RNA
KW - Experimental genetics
KW - Scientific experimentation
KW - Statistics
KW - Analysis of variance
N1 - Accession Number: 22286200; Patterson, Tucker A. 1; Email Address: tucker.patterson@fda.hhs.gov; Lobenhofer, Edward K. 2; Fulmer-Smentek, Stephanie B. 3; Collins, Patrick J. 3; Tzu-Ming Chu 4; Wenjun Bao 4; Hong Fang 5; Kawasaki, Ernest S. 6; Hager, Janet 7; Tikhonova, Irina R. 7; Walker, Stephen J. 8; Liang Zhang 9; Hurban, Patrick 2; de Longueville, Francoise 10; Fuscoe, James C. 1; Weida Tong 1; Leming Shi 1; Wolfinger, Russell D. 4; Affiliations: 1: National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; 2: Cogenics, A Division of Clinical Data, 100 Perimeter Park Drive, Suite C, Morrisville, North Carolina 27560, USA; 3: Integrated Biology Solutions, Agilent Technologies, 5301 Stevens Creek Blvd., Santa Clara, California 95052-8059, USA; 4: SAS Institute Inc., SAS Campus Drive, Cary, North Carolina 27513, USA; 5: Division of Bioinformatics, Z-Tech Corporation at NCTR/FDA, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; 6: NCI Advanced Technology Center, 8717 Grovemont Circle, Bethesda, Maryland 20892-4605, USA; 7: Yale University, W.M. Keck Biotechnology Resource Laboratory, Microarray Resource, 300 George St., Suite 2110, New Haven, Connecticut 06511, USA; 8: Department of Physiology & Pharmacology, Wake Forest University School of Medicine, 115 S. Chestnut St., Winston-Salem, North Carolina 27101, USA; 9: CapitalBio Corporation, 18 Life Science Parkway, Changping District, Beijing 102206, P.R. China; 10: Gene Expression Chips, Eppendorf Array Technologies (EAT), 20, rue du seminaire, 5000 Namur, Belgium; Issue Info: Sep2006, Vol. 24 Issue 9, p1140; Thesaurus Term: Hybridization; Thesaurus Term: Genetics; Subject Term: Messenger RNA; Subject Term: Experimental genetics; Subject Term: Scientific experimentation; Subject Term: Statistics; Subject Term: Analysis of variance; Number of Pages: 11p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1038/nbt1242
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22286200&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Antonini, James M.
AU - O’Callaghan, James P.
AU - Miller, Diane B.
T1 - Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2006/09//
VL - 27
IS - 5
M3 - Article
SP - 745
EP - 751
SN - 0161813X
AB - Abstract: Serious questions have been raised regarding a possible causal association between neurological effects in welders and the presence of manganese in welding fume. An experimental model is needed that could examine the potential neurotoxic effect of manganese after pulmonary exposure to welding fume. The National Institute for Occupational Safety and Health (NIOSH) has recently finished construction of a completely automated, computer controlled welding fume generation and inhalation exposure system for laboratory animals. The system is comprised of a programmable six-axis robotic welding arm and a water-cooled arc welding torch. A flexible trunk has been attached to the robotic arm of the welder and is used to collect and transport fume from the vicinity of the arc to the animal exposure chamber. Preliminary fume characterization studies have indicated that particle morphology, size, and chemical composition were comparable to welding fume generated in the workplace. Animal inhalation studies are currently underway. With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANGANESE -- Physiological effect
KW - WELDING fumes
KW - NEUROTOXICOLOGY
KW - POISONOUS gases -- Toxicology
KW - ANIMAL models in research
KW - Glial fibrillary acidic protein
KW - Inhalation
KW - Welding
N1 - Accession Number: 22010359; Antonini, James M.; Email Address: jga6@cdc.gov O’Callaghan, James P. 1 Miller, Diane B. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Sep2006, Vol. 27 Issue 5, p745; Subject Term: MANGANESE -- Physiological effect; Subject Term: WELDING fumes; Subject Term: NEUROTOXICOLOGY; Subject Term: POISONOUS gases -- Toxicology; Subject Term: ANIMAL models in research; Author-Supplied Keyword: Glial fibrillary acidic protein; Author-Supplied Keyword: Inhalation; Author-Supplied Keyword: Welding; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuro.2006.01.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105880631
T1 - Hooked on safety: using public health methods to prevent accidents in Alaska.
AU - Mode N
Y1 - 2006///2006 Fall-Winter
N1 - Accession Number: 105880631. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Supplement Title: 2006 Fall-Winter. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 101093000.
KW - Fish
KW - Occupational Safety -- Education -- Alaska
KW - Public Health -- Methods
KW - Alaska
KW - Collaboration
KW - Data Analysis
KW - Death, Accidental -- Prevention and Control
KW - Disease Surveillance -- Methods
KW - National Institute for Occupational Safety and Health
KW - Occupational-Related Injuries -- Epidemiology
SP - 6
EP - 24
JO - Northwest Public Health
JF - Northwest Public Health
JA - NORTHWEST PUBLIC HEALTH
VL - 23
IS - 2
CY - Seattle, Washington
PB - University of Washington, School of Public Health & Community Medicine
SN - 1536-9102
AD - Statistician, National Institute for Occupational Safety and Health
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105880631&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105880640
T1 - Wellness in the workplace.
AU - Mode N
Y1 - 2006///2006 Fall-Winter
N1 - Accession Number: 105880640. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2006 Fall-Winter. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 101093000.
KW - Health Promotion -- Methods -- Northwestern United States
KW - Work Environment
KW - Health Screening
KW - Life Style Changes
KW - Northwestern United States
KW - Nutrition
KW - Obesity -- Prevention and Control
KW - Physical Activity
KW - Productivity
KW - Smoking Cessation
KW - Stress Management
SP - 21
EP - 24
JO - Northwest Public Health
JF - Northwest Public Health
JA - NORTHWEST PUBLIC HEALTH
VL - 23
IS - 2
CY - Seattle, Washington
PB - University of Washington, School of Public Health & Community Medicine
AB - According to the Centers for Disease Control and Prevention (CDC), physical inactivity cost the United States nearly $766 billion in direct medical costs in 2000. Obesity, a companion problem with physical inactivity, is also on the increase in the US. CDC estimated that in 1998 medical expenses attributable to being overweight or obese accounted for 9.1 percent of total U S. medical expenditures and may have reached as high as $78.5 billion. Working adults spend up to half of their waking hours at work, so effective initiatives to increase physical activity and healthy eating have the potential to significantly improve workers' health and reduce related health costs. The following articles describe five new workplace wellness initiatives in the Northwest.
SN - 1536-9102
AD - Statistician, National Institute for Occupational Safety and Health
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105880640&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Twery, Michael J.
T1 - The Cartoon Character Garfield and the "Sleep Well. Do Well. Star Sleeper" Campaign.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/09//
VL - 118
IS - 3
M3 - Editorial
SP - 1259
EP - 1259
SN - 00314005
AB - The article comments on the effectiveness of the Sleep Well. Do Well. Star Sleeper campaign at the National Heart, Lung and Blood Institute. The campaign is aimed at educating children about the need to have at least 9 hours of sleep every night to perform well in school, sports and other activities. Garfield has successfully captured the attention of target audiences which is a critical objective for public education campaigns. Children enjoyed the campaign activities while getting the message about the right amount of sleep they need each night.
KW - SLEEP
KW - CHILDREN -- Health
KW - GARFIELD (Fictitious character)
KW - EDUCATION
KW - SPORTS
N1 - Accession Number: 22453628; Twery, Michael J. 1; Email Address: twery@nih.gov; Affiliation: 1: National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland; Source Info: Sep2006, Vol. 118 Issue 3, p1259; Subject Term: SLEEP; Subject Term: CHILDREN -- Health; Subject Term: GARFIELD (Fictitious character); Subject Term: EDUCATION; Subject Term: SPORTS; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 2/3p; Document Type: Editorial
L3 - 10.1542/peds.2006-1433
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22453628&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106365891
T1 - The cartoon character Garfield and the 'Sleep Well. Do Well. Star Sleeper' campaign.
AU - Twery MJ
Y1 - 2006/09//
N1 - Accession Number: 106365891. Language: English. Entry Date: 20061124. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Fox MD. Sleeping with the enemy: Garfield and the National Heart, Lung, and Blood Institute. (PEDIATRICS) Sep2006; 118 (3): 1257-1258. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Advertising
KW - Health Promotion
KW - Sleep
KW - Cats
KW - Child
KW - Child Welfare
KW - Health Education -- Methods
KW - National Institutes of Health (U.S.)
KW - United States
SP - 1259
EP - 1259
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 118
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - National Center on Sleep Disorders Research, National Heart, Lung, and Blood Institute, US Department of Health and Human Services, Bethesda, Maryland 20895-7990, USA. twery@nih.gov
U2 - PMID: 16951023.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106365891&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - RPRT
AU - Frueh, F. W.
AU - Rudman, A.
AU - Simon, K.
AU - Gutman, S.
AU - Reed, C.
AU - Dorner, A. J.
T1 - Experience with voluntary and required genomic data submissions to the FDA: summary report from track 1 of the third FDA-DIA-PWG-PhRMA-BIO pharmacogenomics workshop.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/09//
VL - 6
IS - 5
M3 - Report
SP - 296
EP - 300
PB - Nature Publishing Group
SN - 1470269X
AB - The article presents a summary report of the first of a series of U.S. Food and Drug Administration (FDA) industry workshops on pharmacogenomics which was held to assess the use and status of pharmacogenomic research in drug development in May 2002. The FDA proposed that industry submit pharmacogenomic data to the Agency under a concept that was termed "Safe Harbor." The FDA released the draft "Guidance for Industry: Pharmacogenomic Data Submissions."
KW - PHARMACOGENOMICS
KW - DRUG development
KW - FORUMS (Discussion & debate)
KW - PHARMACOLOGY
KW - PHARMACY
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 22543141; Frueh, F. W. 1; Email Address: Felix.Frueh@FDA.gov Rudman, A. 1 Simon, K. 2 Gutman, S. 2 Reed, C. 3 Dorner, A. J. 4; Affiliation: 1: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA 2: Office of In Vitro Diagnostic Device Evaluation and Safety, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA 3: Genaissance Pharmaceuticals, New Haven, CT, USA 4: Wyeth Research, Cambridge, MA, USA; Source Info: 2006, Vol. 6 Issue 5, p296; Subject Term: PHARMACOGENOMICS; Subject Term: DRUG development; Subject Term: FORUMS (Discussion & debate); Subject Term: PHARMACOLOGY; Subject Term: PHARMACY; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Report
L3 - 10.1038/sj.tpj.6500380
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lei Guo
AU - Lu Zhang
AU - Yongming Sun
AU - Muskhelishvili, Levan
AU - Blann, Ernice
AU - Dial, Stacey
AU - Leming Shi
AU - Schroth, Gary
AU - Dragan, Yvonne P.
T1 - Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPARγ agonists on rat primary hepatocytes and human HepG2 cells.
JO - Plant Foods for Human Nutrition
JF - Plant Foods for Human Nutrition
Y1 - 2006/09//
VL - 61
IS - 3
M3 - Article
SP - 349
EP - 360
PB - Springer Science & Business Media B.V.
SN - 09219668
AB - Agonists of peroxisome proliferator-activated receptor γ (PPARγ) are a new class of oral drugs designed to treat insulin-resistant diabetes (i.e., type 2 diabetes). However, troglitazone, the first compound in the class approved by the US Food and Drug Administration (FDA) in 1997 was found to be hepatotoxic and was withdrawn from the market after reports of severe liver failure. The mechanism of PPARγ agonist-induced hepatotoxicity remains unknown. In this study, we examined the hepatotoxic effects of five PPARγ agonists (ciglitazone, pioglitazone, rosiglitazone, troglitazone, and JTT-501) on rat primary hepatocytes and human HepG2 cells. We also compared the gene expression profiles of rat primary hepatocytes after exposure to PPARγ agonists by using the Rat Genome Survey Microarray system from Applied Biosystems in order to understand the mechanisms of hepatotoxicities induced by PPARγ agonists. Consistent with the hepatotoxicity data, our results demonstrate that the gene expression profiles affected by troglitazone and ciglitazone can be clearly distinguished from those by pioglitazone and rosiglitazone. Genes that are differentially expressed between the more toxic troglitazone/ciglitazone group and the less toxic rosiglitazone/pioglitazone group are involved in necrotic, apoptotic, and cell proliferative pathways. The five compounds were also clustered based on a set of molecular descriptors. The clustering based on chemical structural information is in good agreement with the clustering of compounds based on cytotoxicity or gene expression data, indicating a strong relationship between chemical structure and biological endpoints. Our work suggests that microarray analysis together with toxicological observations can be used to rank drugs for hepatotoxicity and to evaluate the safety of new compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Plant Foods for Human Nutrition is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Apoptosis
KW - Hepatotoxicology
KW - Non-insulin-dependent diabetes
KW - Liver diseases
KW - Antineoplastic antibiotics
KW - Cluster analysis (Statistics)
KW - Peroxisomes
KW - Diabetic acidosis
KW - Diabetes
KW - apoptosis
KW - ciglitazone
KW - cluster analysis
KW - cytotoxicity
KW - JTT-501
KW - molecular descriptors
KW - peroxisome proliferator-activated receptor γ
KW - pioglitazone
KW - rat genome microarray
KW - rat primary hepatocytes
KW - rosiglitazone
KW - troglitazone
N1 - Accession Number: 23232973; Lei Guo 1; Email Address: lei.guo@fda.hhs.gov; Lu Zhang 2; Yongming Sun 3; Muskhelishvili, Levan 4; Blann, Ernice 1; Dial, Stacey 1; Leming Shi 1; Schroth, Gary 2; Dragan, Yvonne P. 1; Affiliations: 1: Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.; 2: Arrays/SDS Research and Development Group, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA.; 3: Bioinformatics Group, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA.; 4: Toxicologic Pathology Associates, NCTR, Jefferson, AR 72079, USA.; Issue Info: Sep2006, Vol. 61 Issue 3, p349; Thesaurus Term: Apoptosis; Subject Term: Hepatotoxicology; Subject Term: Non-insulin-dependent diabetes; Subject Term: Liver diseases; Subject Term: Antineoplastic antibiotics; Subject Term: Cluster analysis (Statistics); Subject Term: Peroxisomes; Subject Term: Diabetic acidosis; Subject Term: Diabetes; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: ciglitazone; Author-Supplied Keyword: cluster analysis; Author-Supplied Keyword: cytotoxicity; Author-Supplied Keyword: JTT-501; Author-Supplied Keyword: molecular descriptors; Author-Supplied Keyword: peroxisome proliferator-activated receptor γ; Author-Supplied Keyword: pioglitazone; Author-Supplied Keyword: rat genome microarray; Author-Supplied Keyword: rat primary hepatocytes; Author-Supplied Keyword: rosiglitazone; Author-Supplied Keyword: troglitazone; Number of Pages: 12p; Document Type: Article
L3 - 10.1007/s11030-006-9038-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Young Park, Gun
AU - Yong Cho, Seung
AU - Hoon Jeon, Dae
AU - Shin Kwak, In
AU - Ho Lee, Kwang
AU - Park, H.J.
T1 - Formation of monomer residues in PS, PC, PA-6 and PVC upon γ-irradiation
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2006/09//
VL - 75
IS - 9
M3 - Article
SP - 1055
EP - 1059
SN - 0969806X
AB - Abstract: Food packaging polymers, polystyrene (PS), polycarbonate (PC), polyamide-6 (PA-6), and polyvinylchloride (PVC), were irradiated with dose in the range 5–200kGy. The quantities of corresponding monomer residues (styrene monomer, bisphenol-A, ε-caprolactam, vinyl chloride) released from target materials were analyzed using a SIM mode of GC/MSD. Styrene monomer in PS showed a slight increase from 740 to 777ppm at 5–30kGy and then decreased as the dose increased from 30 to 200kGy. Bisphenol-A in PC was dose independent at the low doses, 5, 10 and 30kGy, but its level increased from 173 to 473ppm at 30kGy and thereafter remained unchanged through 200kGy. ε-Caprolactam in PA-6 was also dose independent, in the range of 5–200kGy, but its level (122–164ppm) was found to be higher than those (71ppm) of non-irradiated sample. As for PVC, the quantity of vinyl chloride tended to increase from 8 to 18ppm at 5–200kGy. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOMERS
KW - IRRADIATION
KW - RADIATION
KW - POLYVINYL chloride
KW - ε-Caprolactam
KW - Bisphenol-A
KW - Irradiation
KW - Monomer residues
KW - PA-6
KW - PC
KW - PS
KW - PVC
KW - Styrene monomer
KW - Vinyl chloride
N1 - Accession Number: 21664635; Young Park, Gun 1 Yong Cho, Seung 2 Hoon Jeon, Dae 1,3 Shin Kwak, In 3 Ho Lee, Kwang 3 Park, H.J. 1,4; Email Address: hjpark@korea.ac.kr; Affiliation: 1: Graduate School of Biotechnology, Korea University, 1,5-Ka, Anam-Dong, Seongbuk-Ku, Seoul 136-701, Republic of Korea 2: Functional Food Research Center, College of Life Sciences, Korea University, 1,5-Ka, Anam-Dong, Seongbuk-Ku, Seoul 136-701, Republic of Korea 3: Food Packaging Division, Korea Food and Drug Administration (KFDA), 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Republic of Korea 4: Department of Packaging Science, Clemson University, Clemson, South Carolina 29634-0370, USA; Source Info: Sep2006, Vol. 75 Issue 9, p1055; Subject Term: MONOMERS; Subject Term: IRRADIATION; Subject Term: RADIATION; Subject Term: POLYVINYL chloride; Author-Supplied Keyword: ε-Caprolactam; Author-Supplied Keyword: Bisphenol-A; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: Monomer residues; Author-Supplied Keyword: PA-6; Author-Supplied Keyword: PC; Author-Supplied Keyword: PS; Author-Supplied Keyword: PVC; Author-Supplied Keyword: Styrene monomer; Author-Supplied Keyword: Vinyl chloride; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.radphyschem.2005.12.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dnyanmote, Ankur V.
AU - Sawant, Sharmilee P.
AU - Lock, Edward A.
AU - Latendresse, John R.
AU - Warbritton, Alan A.
AU - Mehendale, Harihara M.
T1 - Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2006/09//
VL - 215
IS - 2
M3 - Article
SP - 146
EP - 157
SN - 0041008X
AB - Abstract: Previously we have shown that 90% of streptozotocin (STZ)-induced type-1 diabetic (DB) mice survive from acute renal failure (ARF) and death induced by a normally LD90 dose (75 mg/kg, i.p.) of the nephrotoxicant S-1,2-dichlorovinyl-l-cysteine (DCVC). This remarkable protection is due to a combination of slower progression of DCVC-initiated renal injury and increased compensatory nephrogenic tissue repair in the DB kidneys. BRDU immunohistochemistry revealed that the DB condition led to 4-fold higher number of proximal tubular cells (PTC) entering S-phase of cell cycle. In the present study, we tested the hypothesis that DB-induced augmentation of PTC into S-phase is accompanied by overexpression of the calpain-inhibitor calpastatin, which endogenously prevents the progression of DCVC-initiated renal injury mediated by the calpain escaping out of damaged PTCs. Immunohistochemical detection of renal calpain and its activity in the urine, over a time course after treatment with the LD90 dose of DCVC, indicated progressive increase in leakage of calpain into the extracellular spaces of the injured PTCs of the non-diabetic (NDB) kidneys as compared to the DB kidneys. Calpastatin expression was minimally detected in the NDB kidneys, using immunohistochemistry, over the time course. On the other hand, consistently higher number of tubules in the DB kidney showed calpastatin expression over the time course. The lower leakage of calpain in the DB kidneys was commensurate with constitutively higher expression of calpastatin in the S-phase-laden PTCs of these mice. To test the protective role of newly divided/dividing PTCs, DB mice were given the anti-mitotic agent colchicine (CLC) (2 mg/kg and 1.5 mg/kg, i.p., on days 8 and 10 after STZ injection) prior to challenge with a LD90 dose of DCVC, which led to 100% mortality by 48 h. Mortality was due to rapid progression of DCVC-initiated renal injury, suggesting that newly divided/dividing cells are instrumental in mitigating the progression of DCVC-initiated renal injury in DB. The anti-mitotic effect of CLC in DB kidney is associated with lower expression of calpastatin and higher leakage of calpain in the injured tubules. These findings suggest that constitutively higher cell division in the DB kidney is associated with overexpression of calpastatin, which reduces the progression of DCVC-initiated renal injury mediated by calpain on the one hand and accelerates nephrogenic tissue repair on the other, thereby restoring renal structure and function. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - CALPASTATIN
KW - ACUTE kidney failure
KW - MORTALITY
KW - Acute renal failure
KW - Calpain
KW - Calpastatin
KW - Diabetes
KW - Progression of injury
KW - Tissue repair
N1 - Accession Number: 21911931; Dnyanmote, Ankur V. 1 Sawant, Sharmilee P. 1 Lock, Edward A. 2 Latendresse, John R. 3 Warbritton, Alan A. 3 Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliation: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209-0470, USA 2: School of Biomolecular Sciences, Liverpool JM University, Liverpool, L3 3AF, UK 3: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Sep2006, Vol. 215 Issue 2, p146; Subject Term: DIABETES; Subject Term: CALPASTATIN; Subject Term: ACUTE kidney failure; Subject Term: MORTALITY; Author-Supplied Keyword: Acute renal failure; Author-Supplied Keyword: Calpain; Author-Supplied Keyword: Calpastatin; Author-Supplied Keyword: Diabetes; Author-Supplied Keyword: Progression of injury; Author-Supplied Keyword: Tissue repair; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.taap.2006.01.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21911931&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chou, Ming W.
AU - Fu, Peter P.
T1 - Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2006/09//
VL - 22
IS - 8
M3 - Article
SP - 321
EP - 327
PB - Sage Publications, Ltd.
SN - 07482337
AB - We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report that DHP-derived DNA adducts are formed in the liver of female F344 rats, gavaged with three dietary supplements (comfrey root extract, comfrey compound oil, and coltsfoot root extract), or an extract of a Chinese herbal plant, flos farfara (Kuan Tong Hua). [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Plant extracts
KW - Dietary supplements
KW - Food additives
KW - Phytochemicals
KW - Herbs
KW - Pyrrolizidines
KW - DNA adducts
KW - Herbal medicine
KW - Comfrey
KW - dietary supplement
KW - DNA adduct
KW - PYRROLIZIDINE ALKALOID
KW - RIDDELLIINE
N1 - Accession Number: 22630193; Chou, Ming W. 1; Email Address: mchou@nctr.fda.gov; Fu, Peter P. 1; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: 2006, Vol. 22 Issue 8, p321; Thesaurus Term: Plant extracts; Thesaurus Term: Dietary supplements; Thesaurus Term: Food additives; Thesaurus Term: Phytochemicals; Thesaurus Term: Herbs; Subject Term: Pyrrolizidines; Subject Term: DNA adducts; Subject Term: Herbal medicine; Subject Term: Comfrey; Author-Supplied Keyword: dietary supplement; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: PYRROLIZIDINE ALKALOID; Author-Supplied Keyword: RIDDELLIINE; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1177/0748233706071765
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22630193&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Srinivasan, Kumar
AU - Akolkar, Pradip N.
AU - Taffs, Rolf E.
AU - Hewlett, Indira K.
T1 - Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety.
JO - Transfusion
JF - Transfusion
Y1 - 2006/09//
VL - 46
IS - 9
M3 - Article
SP - 1589
EP - 1592
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS: A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS: Vaccinia viremia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viremia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION: The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMALLPOX -- Vaccination
KW - VACCINIA
KW - VACCINATION
KW - COMMUNICABLE diseases -- Prevention
KW - BLOOD transfusion -- Complications
KW - VIRUS diseases -- Transmission
KW - BLOOD donors
N1 - Accession Number: 22146026; Srinivasan, Kumar 1,2; Email Address: kumar.srinivasan@fda.hhs.gov. Akolkar, Pradip N. 1,2 Taffs, Rolf E. 1,2 Hewlett, Indira K. 1,2; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging, Transmission Transmitted Diseases (DETTD), Rockville, Maryland 2: Laboratory of Bacterial, Parasitic, and Unconventional Agents, Office of Blood Review and Research (OBRR), CBER, Food and Drug Administration, Rockville, Maryland.; Source Info: Sep2006, Vol. 46 Issue 9, p1589; Subject Term: SMALLPOX -- Vaccination; Subject Term: VACCINIA; Subject Term: VACCINATION; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: BLOOD transfusion -- Complications; Subject Term: VIRUS diseases -- Transmission; Subject Term: BLOOD donors; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1537-2995.2006.00936.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22146026&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105849604
T1 - Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety.
AU - Srinivasan K
AU - Akolkar PN
AU - Taffs RE
AU - Hewlett IK
Y1 - 2006/09//
N1 - Accession Number: 105849604. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Immunization -- Standards
KW - Leukocytes, Mononuclear
KW - Smallpox Vaccine -- Administration and Dosage
KW - Smallpox -- Prevention and Control
KW - Animals
KW - Biological Warfare
KW - Clinical Trials
KW - Immunization Programs
KW - Primates
KW - Safety
KW - Smallpox Vaccine -- Adverse Effects
KW - Smallpox Vaccine -- Contraindications
KW - Smallpox -- Transmission
KW - Tissue Culture Techniques
KW - Viremia -- Chemically Induced
KW - Viruses
SP - 1589
EP - 1592
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 46
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND: Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS: A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS: Vaccinia viremia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viremia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION: The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low.
SN - 0041-1132
AD - Laboratory of Molecular Virology, Division of Emerging and Transmission Transmitted Diseases, CBER, Food and Drug Administration, Rockville, Maryland 20852-1448, USA. kumar.srinivasan@fda.hhs.gov
U2 - PMID: 16965588.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105849604&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Srinivasan, Kumar
AU - Akolkar, Pradip N.
AU - Taffs, Rolf E.
AU - Hewlett, Indira K.
T1 - Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety.
JO - Transfusion
JF - Transfusion
Y1 - 2006/09//
VL - 46
IS - 9
M3 - Article
SP - 1589
EP - 1592
SN - 00411132
AB - BACKGROUND: Mass smallpox vaccination with live vaccinia virus has been considered as a preventive measure to counter bioterrorism involving smallpox. This has raised concerns about the possibility of vaccinia virus being transmitted from vaccinated blood donors to recipients. The results of this study could be used to define an appropriate deferral period for blood donors (vaccinated against smallpox) to ensure safety of the blood supply. STUDY DESIGN AND METHODS: A procedure was developed to culture vaccinia virus from plasma and peripheral blood mononuclear cells (PBMNCs) of vaccinees enrolled in three smallpox vaccine clinical trials. A total of 665 plasma and PBMNC samples were obtained from 95 vaccinated subjects. RESULTS: Vaccinia viremia was not detected by virus culture from plasma and PBMNC samples of healthy vaccinees 3 to 56 days after vaccination under our assay conditions. Plasma viremia assay had a sensitivity of approximately 66 plaque-forming units per mL with a Vero cell culture assay. CONCLUSION: The results of this study present evidence that in the case of mass vaccination, the risk of transmission of vaccinia virus by blood transfusion would likely be low. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMALLPOX -- Vaccination
KW - VACCINIA
KW - VACCINATION
KW - COMMUNICABLE diseases -- Prevention
KW - BLOOD transfusion -- Complications
KW - VIRUS diseases -- Transmission
KW - BLOOD donors
N1 - Accession Number: 22146026; Srinivasan, Kumar 1,2; Email Address: kumar.srinivasan@fda.hhs.gov.; Akolkar, Pradip N. 1,2; Taffs, Rolf E. 1,2; Hewlett, Indira K. 1,2; Source Information: Sep2006, Vol. 46 Issue 9, p1589; Subject: SMALLPOX -- Vaccination; Subject: VACCINIA; Subject: VACCINATION; Subject: COMMUNICABLE diseases -- Prevention; Subject: BLOOD transfusion -- Complications; Subject: VIRUS diseases -- Transmission; Subject: BLOOD donors; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1537-2995.2006.00936.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=22146026&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - McGovern, Timothy
AU - Jacobson-Kram, David
T1 - Regulation of genotoxic and carcinogenic impurities in drug substances and products
JO - Trends in Analytical Chemistry: TRAC
JF - Trends in Analytical Chemistry: TRAC
Y1 - 2006/09//
VL - 25
IS - 8
M3 - Article
SP - 790
EP - 795
SN - 01659936
AB - Abstract: While the use of pharmaceuticals is always a balance of risks and benefits, the same is not true for impurities in pharmaceuticals; impurities carry only risk. A number of international guidelines and regional guidance documents instruct drug developers and regulatory agencies on how to evaluate and to control impurities in drug substances and drug products. These guidelines explicitly identify triggers for reporting, identifying and qualifying impurities. In addition, the guidelines provide direction on the assays that should be used to determine if impurities are genotoxic. However, the guidelines fail to provide direction on how levels of genotoxic impurities should be controlled. This article discusses practical and theoretical methods for controlling levels of genotoxic impurities in drug substances and drug products. [Copyright &y& Elsevier]
AB - Copyright of Trends in Analytical Chemistry: TRAC is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - CONTAMINATION (Technology)
KW - GENETIC toxicology
KW - RISK
KW - Carcinogenic
KW - Genotoxic
KW - Impurity
KW - Pharmaceutical
KW - Regulation
N1 - Accession Number: 22082192; McGovern, Timothy 1 Jacobson-Kram, David 2; Email Address: david.jacobsonkram@fda.hhs.gov; Affiliation: 1: Division of Pulmonary and Allergy Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Sep2006, Vol. 25 Issue 8, p790; Subject Term: DRUGS; Subject Term: CONTAMINATION (Technology); Subject Term: GENETIC toxicology; Subject Term: RISK; Author-Supplied Keyword: Carcinogenic; Author-Supplied Keyword: Genotoxic; Author-Supplied Keyword: Impurity; Author-Supplied Keyword: Pharmaceutical; Author-Supplied Keyword: Regulation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.trac.2006.06.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22082192&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-11364-007
AN - 2006-11364-007
AU - Shopland, Donald R.
AU - Anderson, Christy M.
AU - Burns, David M.
T1 - Association between home smoking restrictions and changes in smoking behaviour among employed women.
JF - Journal of Epidemiology and Community Health
JO - Journal of Epidemiology and Community Health
JA - J Epidemiol Community Health
Y1 - 2006/09//
VL - 60
IS - Suppl 2
SP - 44
EP - 50
CY - United Kingdom
PB - BMJ Publishing Group
SN - 0143-005X
AD - Shopland, Donald R., 312 Meadowview Lane, Ringgold, GA, US, 30736
N1 - Accession Number: 2006-11364-007. PMID: 17708010 Other Journal Title: British Journal of Preventive & Social Medicine. Partial author list: First Author & Affiliation: Shopland, Donald R.; US Public Health Service, Ringgold, GA, US. Release Date: 20070326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Smoking Cessation; Tobacco Smoking; Working Women. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2006.
AB - Study objective: Examine trends in home smoking restrictions among employed women not living alone and assess the associations of such restrictions with smoking behaviour. Design: Multivariate logistic regression analysis of major demographic variables and household composition characteristics. Study participants: 128,024 employed female respondents to the Census Bureau's current population survey over the 10 year period 1992 to 2002. Main results: The prevalence of smoke free homes has increased significantly over the past decade. This increase was evident across all demographic and household characteristics examined with the greatest rate of increase seen among smoking households. Nearly 90% of households consisting of all never smoking adult members reported having a smoke free home in 2001-02 compared with 22% of households consisting of all smokers. The extent of smoking restrictions in the home was the most powerful determinant of cessation of all the factors examined in the regression model. Odds of becoming a former smoker (any length) and quit for three months or more were seven to eight times greater among those women reporting their homes were smoke free compared with those whose homes permitted smoking anywhere in the home. Conclusions: Smoke free homes were associated with a highly significant increase in quitting (p<0.0001). However, at this time it is not clear what proportion of the observed effect can be attributed to living in a smoke free home. None the less, the significantly increased probability of quitting correlated with having a smoke free home found in this analysis, are substantially higher than the odds reported in most workplace studies published to date; additional studies are needed to elucidate this relation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - home smoking restrictions
KW - smoking behavior
KW - employed women
KW - 2006
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Working Women
KW - 2006
U1 - Sponsor: American Legacy Foundation, US. Recipients: No recipient indicated
U1 - Sponsor: Flight Attendant Medical Research Foundation, US. Other Details: William Kahan Distinguished Professorship. Recipients: No recipient indicated
DO - 10.1136/jech.2006.045724
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11364-007&site=ehost-live&scope=site
UR - reedonald@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-10304-011
AN - 2006-10304-011
AU - Wu, Li-Tzy
AU - Schlenger, William E.
AU - Galvin, Deborah M.
T1 - Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2006/09//
VL - 84
IS - 1
SP - 102
EP - 113
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Wu, Li-Tzy, Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, P.O. Box 17969, Durham, NC, US, 27715
N1 - Accession Number: 2006-10304-011. PMID: 16483730 Partial author list: First Author & Affiliation: Wu, Li-Tzy; Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, Durham, NC, US. Release Date: 20060828. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wu, Li-Tzy. Major Descriptor: Demographic Characteristics; Flunitrazepam; Ketamine; Lysergic Acid Diethylamide; Methamphetamine. Minor Descriptor: Drug Usage; Methylenedioxymethamphetamine. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Sep, 2006.
AB - [Correction Notice: An erratum for this article was reported in Vol 86(2-3) of Drug and Alcohol Dependence (see record [rid]2006-22472-028[/rid]). The authors wish to make the following statement regarding their paper: In this paper, we reported on the prevalence of use of 'club drugs' by young Americans aged 16-23, based on secondary analyses of data from the National Survey on Drug Use and Health (NSDUH). Unfortunately, we failed to alert readers to methodological differences in NSDUH's approach to assessment of use among the six drugs we studied that may result in underestimates of the prevalence of use of two of them. Use of methamphetamine, MDMA, LSD, and flunitrazepam (Rohypnol) is assessed directly (e.g., 'Have you ever, even once, used LSD, also called 'acid'?), but the use of GHB and ketamine is assessed indirectly. The indirect approach to assessment of GHB and ketamine use may result in underestimates of the prevalence of use of these two drugs. Detailed descriptions of the methods for assessment of use of drugs in NSDUH can be found in (http://www.oas.samhsa.gov/nhsda/methods.cfm#2k2), and readers of our paper are cautioned to interpret carefully the findings related to GHB and ketamine in light of the assessment differences.] Background: The magnitude and the characteristics of the use of methamphetamine, MDMA (Ecstasy), LSD (D-lysergic acid diethylamide), ketamine, GHB (gamma-hydroxybutyrate), and flunitrazepam (Rohypnol) were examined in a probability sample of the U.S. civilian population that included multiethnic urban, suburban, and rural youths aged 16-23 (N=19,084). Methods: Data were drawn from the National Survey on Drug Use and Health (NSDUH). Logistic regression analyses were conducted to identify the characteristics associated with the use of each of these drugs and of multiple drugs. Results: Approximately 20% of youths aged 16-23 reported having ever used one or more of these drugs. Less than 1% of club drug users used club drugs only, and 82% of them had ever used three or more drug classes. Females were more likely than males to report using multiple club drugs. Recent users of methamphetamine were most likely to be females and adolescents aged 16 or 17. Recent users of MDMA tended to be young adults aged 18-21 and residents of metropolitan areas. Most recent users of LSD were adolescents aged 16-19 and those in low-income families. Ketamine users were primarily employed youths. Staying in school and getting married were associated with decreased odds of club drug use. Club drug use was highly associated with the presence of criminal behaviors and recent alcohol abuse or dependence. Conclusions: Adolescents are more likely than young adults to use multiple drugs. The clustering of multidrug use and alcohol use disorder is a cause of concern. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - magnitude
KW - characteristics
KW - use
KW - methamphetamine
KW - D-lysergic acid diethylamide
KW - ketamine
KW - gamma-hydroxybutyrate
KW - flunitrazepam
KW - Ecstasy
KW - 2006
KW - Demographic Characteristics
KW - Flunitrazepam
KW - Ketamine
KW - Lysergic Acid Diethylamide
KW - Methamphetamine
KW - Drug Usage
KW - Methylenedioxymethamphetamine
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention, Division of Workplace Programs. Grant: 270-2003-00001. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse. Grant: R21DA015938. Recipients: Wu, Li-Tzy
DO - 10.1016/j.drugalcdep.2006.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-10304-011&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-5909-2259
UR - litzywu@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12709-005
AN - 2006-12709-005
AU - Zuvekas, Samuel H.
AU - Meyerhoefer, Chad D.
T1 - Coverage for Mental Health Treatment: Do the Gaps Still Persist?
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2006/09//
VL - 9
IS - 3
SP - 155
EP - 163
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Zuvekas, Samuel H., Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2006-12709-005. PMID: 17031020 Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20061016. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Health Insurance; Mental Health Services; Health Care Policy. Minor Descriptor: Mental Health. Classification: Psychological & Physical Disorders (3200); Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2006.
AB - Background: Consumers have long faced high out-of-pocket costs for mental health and substance abuse treatment in private health insurance plans, the predominant form of insurance coverage in the United States. Nominal mental health benefits may have improved from the mid-1990s onwards, as many states passed mental health parity mandates and other employers voluntarily improved coverage. However, the rapid rise of managed behavioral health care organizations (MBHOs) may have effectively offset these gains in nominal coverage. Aims of the Study: We examine how effective mental health benefits, as measured by actual out-of-pocket expenses, compares to coverage for non-mental health treatment and how this has changed in recent years. Methods: We used detailed data on health care use and expenses from the nationally representative, Medical Expenditure Panel Survey (MEPS) to describe the distribution of out-of-pocket expenses for mental health and non-mental health ambulatory visits and prescription drug fills and demonstrate how this changed between 1996 and 2003. In addition, we use two-limit tobit regression models to descriptively examine the factors associated with higher out-of-pocket costs for ambulatory mental health treatment. Results: While out-of-pockets shares generally decreased over the 1996 - 2003 period, from 39 to 35 percent of total expenses for ambulatory mental health visits and from 31 to 26 percent for nonmental health ambulatory visits, the ratio of out-of-pockets costs is still significantly higher for mental health care. Out-of-pocket expenses per visit fell as the number of non-mental health visits increased but out-of-pocket expenses for mental health visits rose with more visits. Out-of-pocket expenses for visits to specialty mental health providers were substantially higher than for nonpsychiatrist physicians. Though prescription drug spending increased substantially, the percent paid out-of-pocket did not change for mental health and non-mental health related fills. Discussion: Our results suggest that expenses for ambulatory mental health visits, especially for specialty providers, effectively remain less well covered than other medical visits. Implications for Health Care Provision and Use: Continued high out-of-pocket expenses for mental health treatment may impede access to mental health treatment, especially for those who need greater treatment intensity. Implications for Health Policies: Mental health parity may not ensure that coverage for mental health services is, in actuality, equal. Implications for Further Research: Additional research is needed in understanding relative changes in nominal vs. actual or effective coverage. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health treatment
KW - substance abuse
KW - health insurance
KW - health policy
KW - 2006
KW - Drug Abuse
KW - Health Insurance
KW - Mental Health Services
KW - Health Care Policy
KW - Mental Health
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12709-005&site=ehost-live&scope=site
UR - szuvekas@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-14493-008
AN - 2011-14493-008
AU - Darensburg, Tahera
AU - Andrew, Michael E.
AU - Hartley, Tara A.
AU - Burchfiel, Cecil M.
AU - Fekedulegn, Desta
AU - Violanti, John M.
T1 - Gender and age differences in posttraumatic stress disorder and depression among Buffalo police officers.
JF - Traumatology
JO - Traumatology
JA - Traumatology (Tallahass Fla)
Y1 - 2006/09//
VL - 12
IS - 3
SP - 220
EP - 228
CY - US
PB - Academy of Traumatology
SN - 1534-7656
SN - 1085-9373
AD - Burchfiel, Cecil M., Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M/S 4020, Morgantown, WV, US, 26505
N1 - Accession Number: 2011-14493-008. Other Journal Title: Traumatology: An International Journal. Partial author list: First Author & Affiliation: Darensburg, Tahera; Rollins School of Public Health, Emory University, Atlanta, GA, US. Other Publishers: Educational Publishing Foundation; Green Cross Project; Sage Publications. Release Date: 20111024. Correction Date: 20140616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Human Sex Differences; Major Depression; Police Personnel; Posttraumatic Stress Disorder. Classification: Psychological & Physical Disorders (3200); Police & Legal Personnel (4290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Center for Epidemiologic Studies Depression Scale; Impact of Event Scale DOI: 10.1037/t00303-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2006. Copyright Statement: Sage Publications. 2006.
AB - Because of the stressful nature of police work, officers maybe at increased risk for posttraumatic stress disorder (PTSD) and depression. The Impact of Event Scale (IES) and Center for Epidemiologic Studies–Depression (CES-D) survey were administered to 100 officers. Mean IES and CES-D scores and prevalence of PTSD and depression were compared across gender and age. Female officers had higher mean IES and CES-D scores than male officers. Mean CES-D scores tended to increase with age, whereas mean IES scores varied little across age. Prevalence of depression was greater among women (22.0%) than men (12.1%), yet differences were less evident for PTSD (36.6% women, 34.5% men). Depression and PTSD tended to increase with age and were not explained by gender, marital status, or education. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender differences
KW - age differences
KW - posttraumatic stress disorder
KW - major depression
KW - police personnel
KW - 2006
KW - Age Differences
KW - Human Sex Differences
KW - Major Depression
KW - Police Personnel
KW - Posttraumatic Stress Disorder
KW - 2006
U1 - Sponsor: National Institute for Occupational Safety and Health, US. Grant: HELD01B0088. Recipients: No recipient indicated
DO - 10.1177/1534765606296271
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-14493-008&site=ehost-live&scope=site
UR - cburchfiel@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12711-006
AN - 2006-12711-006
AU - Geller, Jeffrey L.
AU - Biebel, Kathleen
T1 - The premature demise of public child and adolescent inpatient psychiatric beds: Part I: Overview and current conditions.
JF - Psychiatric Quarterly
JO - Psychiatric Quarterly
JA - Psychiatr Q
Y1 - 2006/09//
VL - 77
IS - 3
SP - 251
EP - 271
CY - Germany
PB - Springer
SN - 0033-2720
SN - 1573-6709
AD - Geller, Jeffrey L., Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-12711-006. PMID: 16912929 Partial author list: First Author & Affiliation: Geller, Jeffrey L.; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20061211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Health Care Delivery; Health Care Psychology; Mental Health Services; Treatment. Classification: Inpatient & Hospital Services (3379). Population: Human (10). Location: US. References Available: Y. Page Count: 21. Issue Publication Date: Sep, 2006.
AB - Current trends on the national landscape of available treatment and delivery systems for children and adolescents with serious emotional disturbance indicate a sharp decline in the availability of inpatient psychiatric services. These trends are troubling as six to nine million children and adolescents in the United States suffer from some serious emotional disturbance, and the majority in need of treatment do not receive behavioral health services. The consequences of untreated mental illness in children are grave, and the cost to society of children's mental health problems is high in both human and fiscal terms. This paper will describe national trends in behavioral health in general and specifically children's mental health, and will detail the experiences of many states to identify possible problems and pitfalls to downsizing and closing child and adolescent inpatient psychiatric beds. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - inpatient psychiatric beds
KW - behavioral health
KW - children's mental health
KW - premature demise
KW - treatment systems
KW - health care delivery
KW - 2006
KW - Death and Dying
KW - Health Care Delivery
KW - Health Care Psychology
KW - Mental Health Services
KW - Treatment
KW - 2006
DO - 10.1007/s11126-006-9012-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12711-006&site=ehost-live&scope=site
UR - Kathleen.Biebel@umassmed.edu
UR - Jeffrey.Geller@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06893-004
AN - 2007-06893-004
AU - Goldcamp, E. Michael
AU - Myers, John
AU - Hendricks, Kitty
AU - Layne, Larry
AU - Helmkamp, Jim
T1 - Nonfatal all-terrain vehicle-related injuries to youths living on farms in the United States, 2001.
JF - The Journal of Rural Health
JO - The Journal of Rural Health
JA - J Rural Health
Y1 - 2006///Fal 2006
VL - 22
IS - 4
SP - 308
EP - 313
CY - United Kingdom
PB - Blackwell Publishing
SN - 0890-765X
SN - 1748-0361
AD - Goldcamp, E. Michael, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 1808, Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2007-06893-004. PMID: 17010027 Partial author list: First Author & Affiliation: Goldcamp, E. Michael; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070723. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Motor Vehicles; Recreation; Rural Environments. Minor Descriptor: Agricultural Workers; Agriculture. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Fal 2006.
AB - Context: Use of all-terrain vehicles (ATVs) in agriculture appears to be growing. Purpose: To provide estimates of ATV ownership and exposure on US farms and an overview of injuries to youths as a result of ATV use on the farm in 2001. Methods: Analysis of the National Institute for Occupational Safety and Health and US Department of Agriculture 2001 Childhood Agricultural Injury Survey. These data, collected via telephone surveys, provide information on nonfatal injuries that occurred to youths younger than 20 years living on US farms during 2001. The injuries included both occupational and nonoccupational incidents. Findings: Of an estimated 1.1 million youths living on farms, 36% had operated an ATV in 2001. Youths younger than 16 years were more likely to have operated an ATV than a tractor on these farms. An estimated 2,246 nonfatal ATV-related injuries occurred to youths younger than 20 years on US farms during 2001. The majority of these ATV injuries (1,668, 74%) occurred to youths identified as members of the household. Males accounted for 1,145 (69%) of the ATV injuries to household youths. The majority of the injuries were to youths aged 10-15 years (1,170, 70%). Most ATV injuries were the result of recreational activities (970, 58%). In addition, many of these injury events involved youths riding without helmets and using ATVs that were larger than the recommended size for their age. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - all terrain vehicles
KW - injuries
KW - youths
KW - farms
KW - agriculture
KW - 2006
KW - Injuries
KW - Motor Vehicles
KW - Recreation
KW - Rural Environments
KW - Agricultural Workers
KW - Agriculture
KW - 2006
DO - 10.1111/j.1748-0361.2006.00051.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06893-004&site=ehost-live&scope=site
UR - ehg8@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21209-002
AN - 2006-21209-002
AU - Meyers, David S.
AU - Mishori, Ranit
AU - McCann, Jessica
AU - Delgado, Jose
AU - O'Malley, Ann S.
AU - Fryer, Ed
T1 - Primary Care Physicians' Perceptions of the Effect of Insurance Status on Clinical Decision Making.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2006/09//Sep-Oct, 2006
VL - 4
IS - 5
SP - 399
EP - 402
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Meyers, David S., Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2006-21209-002. PMID: 17003138 Partial author list: First Author & Affiliation: Meyers, David S.; Capital Area Primary Care Research Network (CAPRICORN), Georgetown University Medical Center, Washington, DC, US. Release Date: 20070205. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Health Care Services; Health Personnel Attitudes; Physicians; Primary Health Care. Minor Descriptor: Health; Health Insurance; Perception. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Visual Analogue Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Sep-Oct, 2006.
AB - Purpose: Americans who do not have health insurance receive fewer health services and have poorer health status than those who have insurance. To better understand this disparity, in this study we characterize primary care physician's perceptions of what effect, if any, patients' insurance status has on their clinical decision making during office visits. Methods: Twenty-five physician members of CAPRICORN, a primary care practice-based research network in metropolitan Washington, DC, completed a brief paper-card survey instrument immediately after each patient encounter during 2 half-day office sessions. Participants saw patients in their usual manner and were given no additional information about their patients or their insurance. Results: Eighty-eight percent of participating physicians reported making at least 1 change in clinical management as a result of a patient's insurance status. They reported altering their management during 99 of 409 patient encounters (24.2%). There was a significant difference in the percentage of visits that involved a change in management for privately insured, publicly insured, and uninsured patients (18.7%, 29.5%, and 43.5% respectively, P = .01). Physicians reported discussing insurance issues with patients during 62.6% of visits during which they made a change in management based on insurance status. Conclusion: Physicians incorporate their patients' insurance status into their clinical decision making and acknowledge they frequently alter their clinical management as a result. Additional research is needed to understand the effect of these changes on patient health and to assist both physicians and patients in enhancing the quality of care delivered within the constraints of the current insurance system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - primary care
KW - physicians perceptions
KW - insurance status
KW - clinical decision making
KW - health status
KW - health services
KW - 2006
KW - Decision Making
KW - Health Care Services
KW - Health Personnel Attitudes
KW - Physicians
KW - Primary Health Care
KW - Health
KW - Health Insurance
KW - Perception
KW - 2006
DO - 10.1370/afm.574
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21209-002&site=ehost-live&scope=site
UR - dmeyers@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-11174-005
AN - 2006-11174-005
AU - Fisher, William H.
AU - Silver, Eric
AU - Wolff, Nancy
T1 - Beyond Criminalization: Toward a Criminologically Informed Framework for Mental Health Policy and Services Research.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2006/09//
VL - 33
IS - 5
SP - 544
EP - 557
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Fisher, William H., Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-11174-005. PMID: 16791518 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Fisher, William H.; Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20061016. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Justice; Criminology; Mental Disorders; Mental Health Services; Health Care Policy. Minor Descriptor: Legal Arrest; Mentally Ill Offenders; Risk Factors. Classification: Criminal Behavior & Juvenile Delinquency (3236); Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: Sep, 2006.
AB - The problems posed by persons with mental illness involved with the criminal justice system are vexing ones that have received attention at the local, state and national levels. The conceptual model currently guiding research and social action around these problems is shaped by the 'criminalization' perspective and the associated belief that reconnecting individuals with mental health services will by itself reduce risk for arrest. This paper argues that such efforts are necessary but possibly not sufficient to achieve that reduction. Arguing for the need to develop a services research framework that identifies a broader range of risk factors for arrest, we describe three potentially useful criminological frameworks--the 'life course,' 'local life circumstances' and 'routine activities' perspectives. Their utility as platforms for research in a population of persons with mental illness is discussed and suggestions are provided with regard to how services research guided by these perspectives might inform the development of community-based services aimed at reducing risk of arrest. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - criminalization
KW - mental health policy
KW - mental health services
KW - mental illness
KW - criminal justice
KW - risk factors
KW - arrest
KW - criminology
KW - 2006
KW - Criminal Justice
KW - Criminology
KW - Mental Disorders
KW - Mental Health Services
KW - Health Care Policy
KW - Legal Arrest
KW - Mentally Ill Offenders
KW - Risk Factors
KW - 2006
U1 - Sponsor: Center for Mental Health Services Research. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: PO1-MH66170. Recipients: No recipient indicated
DO - 10.1007/s10488-006-0072-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11174-005&site=ehost-live&scope=site
UR - Nwolff@ifn.rutgers.edu
UR - exs44@psu.edu
UR - Bill.Fisher@Umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-11202-017
AN - 2006-11202-017
AU - Holden, E. Wayne
AU - Blau, Gary M.
T1 - An expanded perspective on children's mental health.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 2006/09//
VL - 61
IS - 6
SP - 642
EP - 644
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
AD - Holden, E. Wayne, Social and Statistical Sciences, RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC, US, 27709-2194
N1 - Accession Number: 2006-11202-017. PMID: 16953761 Partial author list: First Author & Affiliation: Holden, E. Wayne; Social and Statistical Sciences, RTI International, Research Triangle Park, NC, US. Release Date: 20060905. Correction Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Childhood Development; Evidence Based Practice; Mental Disorders; Mental Health Services; Primary Mental Health Prevention. Minor Descriptor: Adolescent Development; Family Intervention; Models; Health Care Policy. Classification: Health & Mental Health Treatment & Prevention (3300). References Available: Y. Page Count: 3. Issue Publication Date: Sep, 2006. Copyright Statement: American Psychological Association. 2006.
AB - Comments on three articles (see records [rid]2005-11115-003[/rid], [rid]2005-11115-004[/rid], and [rid]2005-11115-005[/rid]) on the status of children's mental health services in the United States, which appeared in the September 2005 issue of the American Psychologist. The current authors suggest that, although this series of articles provides important information, the articles fall short in meeting the mark of comprehensively describing the solutions necessary to effectively address the crisis facing children's mental health in this country. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - youth mental health
KW - mental disorders
KW - evidence based prevention
KW - treatment
KW - family intervention
KW - frameworks
KW - mental health policy reform
KW - 2006
KW - Childhood Development
KW - Evidence Based Practice
KW - Mental Disorders
KW - Mental Health Services
KW - Primary Mental Health Prevention
KW - Adolescent Development
KW - Family Intervention
KW - Models
KW - Health Care Policy
KW - 2006
DO - 10.1037/0003-066X.61.6.642
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11202-017&site=ehost-live&scope=site
UR - wholden@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16636-004
AN - 2007-16636-004
AU - Sedrakyan, Artyom
AU - Vaccarino, Viola
AU - Elefteriades, John A.
AU - Mattera, Jennifer A.
AU - Lin, Zhenqiu
AU - Roumanis, Sarah A.
AU - Krumholz, Harlan M.
T1 - Health related quality of life after mitral valve repairs and replacements.
JF - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JO - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JA - Qual Life Res
Y1 - 2006/09//
VL - 15
IS - 7
SP - 1153
EP - 1160
CY - Germany
PB - Springer
SN - 0962-9343
SN - 1573-2649
AD - Sedrakyan, Artyom, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-16636-004. PMID: 17004004 Partial author list: First Author & Affiliation: Sedrakyan, Artyom; Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20080128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, 3rd. Major Descriptor: Health; Heart Surgery; Quality of Life; Surgical Patients. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Medical Outcomes Trust Short Form 36-item Health Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2006.
AB - Background: The decision to replace or repair mitral valves is often a difficult decision, and outcomes from the patients' perspective should guide decision-making. We investigated whether the change in health related quality of life (HRQOL) after mitral valve surgery is different after valve repairs compared with replacements. Methods: We prospectively studied 25 patients with mitral valve replacement and 45 patients with valve repairs performed in 1998-99. We measured HRQOL at baseline and at 18 months using the Medical Outcomes Trust Short Form 36-item Health Survey (SF-36) questionnaire. We compared mean HRQOL scores of the groups with age-adjusted U.S. population scores. We used analysis of covariance to determine a change in HRQOL within groups (repair or replacement) and if the change in HRQOL was different between the groups. Results: We found few differences between the groups, with more men and simultaneous coronary artery bypass graft surgery in the valve repair group and more prior operation in the valve replacement group. HRQOL improved after surgery in most domains, and was comparable to age-adjusted U.S. norms in the valve repair group. In the multivariable analysis, mitral valve repair recipients reported higher social functioning compared with patients who received valve replacement (p = 0.04). We did not find other statistically significant differences. However, the adjusted improvements in the component scales of physical functioning (PCS) and mental functioning (MCS) were substantial in the valve repair group (mean changes: PCS = 6.8, p = 0.003; MCS = 8.1, p = 0.014) and less pronounced in the replacement group (mean changes: PCS = 3.6, p = 0.09; MCS = 4.3, fsp = 0.16). Conclusions: While many considerations influence the decision to repair or replace mitral valves, these findings suggest that repair may be better from the health status perspective. Further studies are necessary to validate this finding. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health related quality of life
KW - mitral valve repair
KW - mitral valve replacement
KW - heart surgery
KW - post surgery outcomes
KW - 2006
KW - Health
KW - Heart Surgery
KW - Quality of Life
KW - Surgical Patients
KW - 2006
DO - 10.1007/s11136-006-0055-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16636-004&site=ehost-live&scope=site
UR - asedraky@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Donald R.Shopland
AU - Anderson, Christy M.
AU - Burns, David M.
T1 - Association between home smoking restrictions and changes in smoking bahaviour among employed women.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2006/09/02/Sep2006 Supplement 2
VL - 60
M3 - Article
SP - ii44
EP - ii50
SN - 0143005X
AB - Study objective: Examine trends in home smoking restrictions among employed women not living alone and assess the associations of such restrictions with smoking behaviour. Design: Multivariate logistic regression analysis of major demographic variables and household composition characteristics. Study participants: 128 024 employed female respondents to the Census Bureau's current population survey over the 10 year period 1992 to 2002. Main results: The prevalence of smoke free homes has increased significantly over the past decade. This increase was evident across all demographic and household characteristics examined with the greatest rate of increase seen among smoking households. Nearly 90% of households consisting of all never smoking adult members reported having a smoke free home in 2001-02 compared with 22% of households consisting of all smokers. The extent of smoking restrictions in the home was the most powerful determinant of cessation of all the factors examined in the regression model. Odds of becoming a former smoker (any length) and quit for three months or more were seven to eight times greater among those women reporting their homes were smoke free compared with those whose homes permitted smoking anywhere in the home. Conclusions: Smoke free homes were associated with a highly significant increase in quitting (p<0.0001). However, at this time it is not clear what proportion of the observed effect can be attributed to living in a smoke free home. None the less, the significantly increased probability of quitting correlated with having a smoke free home found in this analysis, are substantially higher than the odds reported in most workplace studies published to date; additional studies are needed to elucidate this relation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Epidemiology & Community Health is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOMEN employees
KW - SMOKING
KW - RESTRICTIONS
KW - CIGARETTE smokers
KW - WORK environment
KW - SOCIAL policy
N1 - Accession Number: 22247048; Donald R.Shopland 1 Anderson, Christy M. 2 Burns, David M. 2; Affiliation: 1: US Public Health Service, Ringgold, USA 2: Tobacco Control Policies Project, University of California of San Diego, USA; Source Info: Sep2006 Supplement 2, Vol. 60, pii44; Subject Term: WOMEN employees; Subject Term: SMOKING; Subject Term: RESTRICTIONS; Subject Term: CIGARETTE smokers; Subject Term: WORK environment; Subject Term: SOCIAL policy; Number of Pages: 7p; Document Type: Article
L3 - 10.1136/jech.2006.045724
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hersh, William R
AU - Hickam, David H
AU - Erlichman, Martin
T1 - The evidence base of telemedicine: overview of the supplement.
JO - Journal of Telemedicine & Telecare
JF - Journal of Telemedicine & Telecare
Y1 - 2006/09/02/Sep2006 Supplement 2
VL - 12
M3 - Article
SP - 1
EP - 2
SN - 1357633X
AB - The article presents an overview of the evidence base in telemedicine. It discusses the advocacy of the information technology in health care. These are papers featured in a workshop on March 30 and 31, 2005 commissioned by the U.S. Agency for Healthcare Research and Quality (AHRQ) and Centers for Medicare and Medicaid Services.
KW - TELECOMMUNICATION in medicine
KW - WORKSHOPS (Adult education)
KW - MEDICAL care -- United States
KW - MEDICAL care
KW - MEDICAL telematics
N1 - Accession Number: 22404940; Hersh, William R 1; Email Address: hersh@ohsu.edu Hickam, David H 1,2 Erlichman, Martin 3; Affiliation: 1: Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA 2: Division of Hospital and Speciality Medicine, VA Medical Center, Portland, Oregon, USA 3: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland, USA; Source Info: Sep2006 Supplement 2, Vol. 12, p1; Subject Term: TELECOMMUNICATION in medicine; Subject Term: WORKSHOPS (Adult education); Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care; Subject Term: MEDICAL telematics; Number of Pages: 2p; Document Type: Article
L3 - 10.1258/135763306778393081
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22404940&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Banoo, Shabir
AU - Bell, David
AU - Bossuyt, Patrick
AU - Herring, Alan
AU - Mabey, David
AU - Poole, Freddie
AU - Smith, Peter G
AU - Sriram, N.
AU - Wongsrichanalai, Chansuda
AU - Linke, Ralf
AU - O'Brien, Rick
AU - Perkins, Mark
AU - Cunningham, Jane
AU - Matsoso, Precious
AU - Nathanson, Carl Michael
AU - Olliaro, Piero
AU - Peeling, Rosanna W.
AU - Ramsay, Andy
T1 - Evaluation of diagnostic tests for infectious diseases: general principles.
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
Y1 - 2006/09/02/Sep2006 Supplement
VL - 4
M3 - Article
SP - S21
EP - S31
PB - Nature Publishing Group
SN - 17401526
AB - The TDR Diagnostics Evaluation Expert Panel [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Microbiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSIS
KW - DRUGS -- Side effects
KW - COMMUNICABLE diseases
KW - EPIDEMIOLOGY
KW - DIAGNOSTIC microbiology
KW - CLINICAL trials
N1 - Accession Number: 22543311; Banoo, Shabir 1 Bell, David 2 Bossuyt, Patrick 3 Herring, Alan 4 Mabey, David 5 Poole, Freddie 6 Smith, Peter G 7 Sriram, N. 8 Wongsrichanalai, Chansuda 9 Linke, Ralf 10 O'Brien, Rick 10 Perkins, Mark 10 Cunningham, Jane 11 Matsoso, Precious 11 Nathanson, Carl Michael 11 Olliaro, Piero 11 Peeling, Rosanna W. 11; Email Address: peelingr@who.int Ramsay, Andy 11; Affiliation: 1: Medicines Control Council of South Africa, Pretoria, South Africa 2: Malaria and other Vector-borne and Parasitic Diseases, World Health Organization—Regional Office for the Western Pacific, Manila, Philippines 3: Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands 4: Veterinary School, University of Bristol, Bristol, UK 5: Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK 6: Division of Microbiology Devices, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, USA 7: Infectious Diseases Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK 8: Tulip Group of Companies, Goa, India 9: US Naval Medical Research Unit 2, Jakarta, Indonesia 10: Foundation for Innovative Diagnostics (FIND), Geneva, Switzerland 11: UNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland; Source Info: Sep2006 Supplement, Vol. 4, pS21; Subject Term: DIAGNOSIS; Subject Term: DRUGS -- Side effects; Subject Term: COMMUNICABLE diseases; Subject Term: EPIDEMIOLOGY; Subject Term: DIAGNOSTIC microbiology; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; Number of Pages: 1p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1038/nrmicro1523
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22543311&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, J. Terrig
AU - Prakash, David
AU - Weih, Karis
AU - Moos Jr., Malcolm
T1 - CDMP1/GDF5 Has Specific Processing Requirements That Restrict Its Action to Joint Surfaces.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/09/08/
VL - 281
IS - 36
M3 - Article
SP - 26725
EP - 26733
SN - 00219258
AB - CDMP1/GDF5 has not demonstrated biological activity in Xenopus embryos when overexpressed by mRNA injection. We provide biological and biochemical evidence that to become active, the protein requires cleavage by two distinct proteolytic enzymes. We demonstrate a specific overlap in the expression patterns of CDMP1/GDF5 with the proteases required to release the mature peptide at the location of the future articular surface but not in the future joint space. Taken together, these observations provide a plausible mechanism for local action of CDMP1/GDF5 consistent with requirements imposed by current models of pattern formation in the developing limb. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GROWTH factors
KW - BONE morphogenetic proteins
KW - PROTEOLYTIC enzymes
KW - PROTEINS
KW - MESSENGER RNA
KW - PEPTIDES
KW - BIOCHEMISTRY
N1 - Accession Number: 23504778; Thomas, J. Terrig 1 Prakash, David 1 Weih, Karis 1 Moos Jr., Malcolm 1; Email Address: malcolm.moos@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 9/8/2006, Vol. 281 Issue 36, p26725; Subject Term: GROWTH factors; Subject Term: BONE morphogenetic proteins; Subject Term: PROTEOLYTIC enzymes; Subject Term: PROTEINS; Subject Term: MESSENGER RNA; Subject Term: PEPTIDES; Subject Term: BIOCHEMISTRY; Number of Pages: 9p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1074/jbc.M603851200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wood, Steven C.
AU - Bushar, Grace
AU - Tesfamariam, Belay
T1 - Inhibition of mammalian target of rapamycin modulates expression of adhesion molecules in endothelial cells
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2006/09/10/
VL - 165
IS - 3
M3 - Article
SP - 242
EP - 249
SN - 03784274
AB - Abstract: Neointimal hyperplasia often follows angioplasty-induced arterial injury or stenting and results in restenosis. Previous reports have suggested that arterial injury activates complement which amplifies inflammatory responses that may initiate and sustain neointimal hyperplasia. The effects of rapamycin on complement-induced expression of intracellular adhesion molecules (ICAMs) were examined in porcine arterial endothelial cell (PAEC) line that was transformed with large T antigen. Porcine complement was activated by treating sera with zymosan (PO ZYM) to generate C5b-9. C5b-9 binds to PAEC in a concentration- and time-dependent manner. PO ZYM-induced expression of ICAMs was maximally induced by 18h. Rapamycin reduced the expression of vascular cell adhesion molecule (VCAM) and P-selectin in a concentration-dependent manner. Adhesion of monocytes was reduced by rapamycin and the inhibition was prevented by antibodies to vascular cell adhesion molecule, P-selectin and endothelial–leukocyte adhesion molecule (ELAM). In summary, inhibition of the mammalian target of rapamycin down regulates complement-induced ICAMs expression which may modulate inflammatory responses that follow stent implant-induced restenosis during percutanous coronary interventions. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cell adhesion
KW - Cell adhesion molecules
KW - Immunosuppressive agents
KW - Hyperplasia
KW - Endothelial cells
KW - mTOR signaling
KW - Rapamycin
N1 - Accession Number: 21493883; Wood, Steven C. 1; Email Address: steven.wood@fda.hhs.gov; Bushar, Grace 1; Tesfamariam, Belay 2; Affiliations: 1: Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, CDRH, FDA, Building 64, Rm 3026, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA; 2: Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, Silver Spring, MD, USA; Issue Info: Sep2006, Vol. 165 Issue 3, p242; Thesaurus Term: Cell adhesion; Subject Term: Cell adhesion molecules; Subject Term: Immunosuppressive agents; Subject Term: Hyperplasia; Author-Supplied Keyword: Endothelial cells; Author-Supplied Keyword: mTOR signaling; Author-Supplied Keyword: Rapamycin; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.04.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=21493883&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, Ling
AU - Mei, Nan
AU - Yao, Lei
AU - Chen, Tao
T1 - Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2006/09/10/
VL - 165
IS - 3
M3 - Article
SP - 250
EP - 256
SN - 03784274
AB - Abstract: Aristolochic acid (AA) is present in at least 65 different kinds of plants, many of which are used as herbal folk remedies. AA is considered one of the most potent plant carcinogens in humans and animals. It has been associated with the development of urothelial cancers in humans, and kidney and forestomach tumors in rats. In the present study, we used the Big Blue transgenic rat model to evaluate the mutagenicity of AA in kidney of rats and to define the mechanism of action for the tumor induction by AA. Groups of six male Big Blue transgenic rats were gavaged with 0, 0.1, 1.0 and 10.0mgAA/kg body weight 5 times a week for 12 weeks, a treatment protocol that resulted in tumors in kidneys and other tissues. The animals were sacrificed 1 day after the final treatment and the kidneys were isolated for assays to determine the mutant frequencies (MFs) and types of mutations induced by AA in the transgenic cII gene. AA treatment resulted in a strong linear relationship between MF inductions and treatment dose (R 2 =0.998). The cII MFs were 29±6×10−6, 78±21×10−6, 242±104×10−6 and 1319±360×10−6 in the control, low, medium and high dose treatment groups, respectively (p <0.001 for all pair wise comparisons among the four treatment groups). These MFs correlated strongly with tumor incidences induced by the different doses of AA (). Sequence analysis of the cII mutants revealed that there was a statistically significant difference between the mutational spectra in the AA-treated and control rats (p <0.05). A:T→T:A transversion was the predominant type of mutation in the AA-treated rats whereas G:C→A:T transition was the main type of mutations in the control rats. These results suggest that AA induces kidney tumors in rats though a mutagenic mechanism of action. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Muridae
KW - Mutagenicity testing
KW - Aristolochia
KW - Anthropometry
KW - Aristolochic acid
KW - Carcinogenesis
KW - Herb
KW - Kidney
KW - Mutagenicity
KW - Mutational spectrum
N1 - Accession Number: 21493884; Chen, Ling 1,2; Mei, Nan 1; Yao, Lei 3; Chen, Tao 1,2; Email Address: tchen@nctr.fda.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, HFT-130, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: College of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China; 3: College of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China; Issue Info: Sep2006, Vol. 165 Issue 3, p250; Thesaurus Term: Muridae; Thesaurus Term: Mutagenicity testing; Subject Term: Aristolochia; Subject Term: Anthropometry; Author-Supplied Keyword: Aristolochic acid; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Herb; Author-Supplied Keyword: Kidney; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Mutational spectrum; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.04.008
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Saha, Sukumar
AU - Takeshita, Fumihiko
AU - Sasaki, Shin
AU - Matsuda, Tomoko
AU - Tanaka, Toshiyuki
AU - Tozuka, Miyuki
AU - Takase, Keiko
AU - Matsumoto, Tetsuya
AU - Okuda, Katsuji
AU - Ishii, Norihisa
AU - Yamaguchi, Keizo
AU - Klinman, Dennis M.
AU - Xin, Ke-Qin
AU - Okuda, Kenji
T1 - Multivalent DNA vaccine protects mice against pulmonary infection caused by Pseudomonas aeruginosa
JO - Vaccine
JF - Vaccine
Y1 - 2006/09/11/
VL - 24
IS - 37-39
M3 - Article
SP - 6240
EP - 6249
SN - 0264410X
AB - Abstract: For efficacious vaccine development against Pseudomonas aeruginosa (P. aeruginosa), the immunogenicity of multivalent DNA vaccine was evaluated. Three different plasmids each targeting a fusion of outer membrane proteins (OprF/OprI), a protein regulating type III secretion system (PcrV), or an appendage (PilA) were prepared and mice were immunized with single (monovalent) or a combination of these plasmids (multivalent) via intramuscular electroporation (imEPT) or gene gun. Immunization with multivalent DNA vaccine via imEPT induced the most potent protection against lethal pneumonia. Although the serum levels of IgG binding to whole bacteria cells were comparable between groups, the strongest immune protection was associated with the serum levels of Th1-dominated multivalent IgG, the bronchoalveolar levels of macrophage inflammatory protein 2 (MIP-2) and IFN-γ, and the number of neutrophils and macrophages in the bronchoalveolar lavage following intranasal challenge. These results implied the possible clinical application of multivalent DNA vaccine against P. aeruginosa. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - DNA vaccines
KW - Pseudomonas aeruginosa
KW - Vaccines
KW - DNA vaccine
KW - Multivalency
N1 - Accession Number: 22134721; Saha, Sukumar 1; Takeshita, Fumihiko 1; Sasaki, Shin 1; Matsuda, Tomoko 1; Tanaka, Toshiyuki 1; Tozuka, Miyuki 1; Takase, Keiko 1; Matsumoto, Tetsuya 2; Okuda, Katsuji 3; Ishii, Norihisa 4; Yamaguchi, Keizo 2; Klinman, Dennis M. 5; Xin, Ke-Qin 1; Okuda, Kenji 1; Email Address: kokuda@med.yokohama-cu.ac.jp; Affiliations: 1: Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; 2: Department of Microbiology, Toho University School of Medicine, Tokyo 143-0015, Japan; 3: Department of Microbiology, Tokyo Dental University, Chiba 261-0011, Japan; 4: Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189-0002, Japan; 5: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Sep2006, Vol. 24 Issue 37-39, p6240; Thesaurus Term: Nucleic acids; Subject Term: DNA vaccines; Subject Term: Pseudomonas aeruginosa; Subject Term: Vaccines; Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: Multivalency; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.05.077
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sambandamurthy, Vasan K.
AU - Derrick, Steven C.
AU - Hsu, Tsungda
AU - Chen, Bing
AU - Larsen, Michelle H.
AU - Jalapathy, Kripa V.
AU - Chen, Mei
AU - Kim, John
AU - Porcelli, Steven A.
AU - Chan, John
AU - Morris, Sheldon L.
AU - Jacobs, William R.
T1 - Mycobacterium tuberculosis ΔRD1 ΔpanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis
JO - Vaccine
JF - Vaccine
Y1 - 2006/09/11/
VL - 24
IS - 37-39
M3 - Article
SP - 6309
EP - 6320
SN - 0264410X
AB - Abstract: The global epidemic of tuberculosis (TB), fueled by the growing HIV pandemic, warrants the development of a safe and effective vaccine against TB. We report the construction and characterization of an unlinked double deletion mutant of Mycobacterium tuberculosis H37Rv that deletes both the primary attenuating mutation of BCG (ΔRD1) and two genes required for the synthesis of pantothenate (ΔpanCD). The M. tuberculosis ΔRD1 ΔpanCD (mc26030) mutant undergoes limited replication in mice, and yet is both significantly safer than BCG in immunocompromised mice and also safe in guinea pigs. Additionally, the mc26030 strain does not reactivate in a mouse chemo-immunosuppression model. Importantly, long-lived protective immune responses following immunization with the mc26030 strain prolong the survival of wild type mice, and CD4-deficient mice against an aerosol challenge with virulent M. tuberculosis. Given its overall safety and effectiveness, the mc26030 live attenuated strain should be considered as a human vaccine candidate for protecting both healthy and HIV-infected individuals against TB. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Mycobacterial diseases
KW - Lung diseases
KW - BCG vaccination
KW - Attenuated strains
KW - BCG
KW - Mycobacterial vaccines
N1 - Accession Number: 22134730; Sambandamurthy, Vasan K. 1,2; Derrick, Steven C. 3; Hsu, Tsungda 1; Chen, Bing 1,4; Larsen, Michelle H. 1,4; Jalapathy, Kripa V. 1; Chen, Mei 1; Kim, John 1; Porcelli, Steven A. 1,5; Chan, John 1,5; Morris, Sheldon L. 3; Jacobs, William R. 1,4; Email Address: jacobsw@hhmi.org; Affiliations: 1: Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, United States; 2: Novartis Institute for Tropical Diseases, Singapore 138670, Singapore; 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States; 4: Howard Hughes Medical Institute, United States; 5: Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States; Issue Info: Sep2006, Vol. 24 Issue 37-39, p6309; Thesaurus Term: Tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Lung diseases; Subject Term: BCG vaccination; Author-Supplied Keyword: Attenuated strains; Author-Supplied Keyword: BCG; Author-Supplied Keyword: Mycobacterial vaccines; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.05.097
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Benjamin Jr., Daniel L.
AU - Smith, Philip Brian
AU - Murphy, M. Dianne
AU - Roberts, Rosemary
AU - Mathis, Lisa
AU - Avant, Debbie
AU - Califf, Robert M.
AU - Li, Jennifer S.
T1 - Peer-Reviewed Publication of Clinical Trials Completed for Pediatric Exclusivity.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/09/13/
VL - 296
IS - 10
M3 - Article
SP - 1266
EP - 1273
SN - 00987484
AB - The authors report on the effects of pediatric exclusivity granted by the U.S. Food and Drug Administration (FDA) which allows the extension of marketing rights for drugs for which FDA-requested pediatric trials have been conducted. The pediatric exclusivity program has encouraged studies of drugs in children, but the coverage of these results in the peer-reviewed literature is limited. The U.S. Congress had authorized the FDA to grant the extensions since pediatric drugs were being used off-label due to the lack of pediatric studies. The authors analyzed all trials conducted for pediatric exclusivity between 1998 and 2004.
KW - PEDIATRICS -- Formulae, receipts, prescriptions
KW - DRUGS -- Marketing
KW - CLINICAL medicine -- Research
KW - PEER review (Professional performance)
KW - SCHOLARLY periodicals
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - UNITED States. Congress
N1 - Accession Number: 22295259; Benjamin Jr., Daniel L. 1,2; Email Address: daniel.benjamin@fda.gov Smith, Philip Brian 2 Murphy, M. Dianne 1 Roberts, Rosemary 3 Mathis, Lisa 3 Avant, Debbie 3 Califf, Robert M. 2 Li, Jennifer S. 1,2; Affiliation: 1: Office of Pediatric Therapeutics, Office of the Commissioner US Food and Drug Administration, Rockville, Md 2: Departments of Pediatrics and Medicine and the Duke Clinical Research Institute, Duke University, Durham, NC 3: Office of Counter-Terrorism and Pediatric Drug Development, Center for Drug Evaluation and Research US Food and Drug Administration, Rockville, Md; Source Info: 9/13/2006, Vol. 296 Issue 10, p1266; Subject Term: PEDIATRICS -- Formulae, receipts, prescriptions; Subject Term: DRUGS -- Marketing; Subject Term: CLINICAL medicine -- Research; Subject Term: PEER review (Professional performance); Subject Term: SCHOLARLY periodicals; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration Company/Entity: UNITED States. Congress; NAICS/Industry Codes: 511120 Periodical Publishers; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 921120 Legislative Bodies; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106251605
T1 - Peer-reviewed publication of clinical trials completed for pediatric exclusivity.
AU - Benjamin DK Jr.
AU - Smith PB
AU - Murphy MD
AU - Roberts R
AU - Mathis L
AU - Avant D
AU - Califf RM
AU - Li JS
AU - Benjamin, Daniel K Jr
AU - Smith, Philip Brian
AU - Murphy, M Dianne
AU - Roberts, Rosemary
AU - Mathis, Lisa
AU - Avant, Debbie
AU - Califf, Robert M
AU - Li, Jennifer S
Y1 - 2006/09/13/
N1 - Accession Number: 106251605. Language: English. Entry Date: 20070316. Revision Date: 20161114. Publication Type: journal article; research; systematic review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: U10 HD045962-04/HD/NICHD NIH HHS/United States. NLM UID: 7501160.
KW - Clinical Trials
KW - Drugs
KW - Pediatric Care
KW - Publishing
KW - Confidence Intervals
KW - Data Analysis Software
KW - Drug Labeling
KW - Embase
KW - Funding Source
KW - Logistic Regression
KW - Medline
KW - Multivariate Analysis
KW - Odds Ratio
KW - Peer Review
KW - Two-Tailed Test
KW - Human
SP - 1266
EP - 1273
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 296
IS - 10
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Much of pediatric drug use is off-label because appropriate pediatric studies have not been conducted and the drugs have not been labeled by the US Food and Drug Administration (FDA) for use in children. In 1997, Congress authorized the FDA to grant extensions of marketing rights known as "pediatric exclusivity" if FDA-requested pediatric trials were conducted. As a result, there have been over 100 product labeling changes. The publication status of studies completed for pediatric exclusivity has not been evaluated.Objective: To quantify the dissemination of results of studies conducted for pediatric exclusivity into the peer-review literature.Design: Cohort study of all trials conducted for pediatric exclusivity between 1998 and 2004 as determined by MEDLINE and EMBASE searches through 2005, the subsequent labeling changes, and the publication of those studies in peer-reviewed journals. We categorized any labeling changes resulting from the studies as positive or negative for the drug under study. We then evaluated aspects of the studies and product label changes that were associated with subsequent publication in peer-reviewed medical journals.Main Outcome Measures: Publication of the trial data in peer-reviewed journals.Results: Between 1998 and 2004, 253 studies were submitted to the FDA for pediatric exclusivity: 125 (50%) evaluated efficacy, 51 (20%) were multi-dose pharmacokinetic, 34 (13%) were single-dose pharmacokinetic, and 43 (17%) were safety studies. Labeling changes were positive for 127/253 (50%) of studies; only 113/253 (45%) were published. Efficacy studies and those with a positive labeling change were more likely to be published.Conclusions: The pediatric exclusivity program has been successful in encouraging drug studies in children. However, the dissemination of these results in the peer-reviewed literature is limited. Mechanisms to more widely disperse this information through publication warrant further evaluation.
SN - 0098-7484
AD - Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Md, USA
AD - Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Md, USA. danny.benjamin@duke.edu
U2 - PMID: 16968851.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106115643
T1 - Screening for developmental dysplasia of the hip.
AU - Mabry IR
AU - Luckhaupt S
Y1 - 2006/09/15/
N1 - Accession Number: 106115643. Language: English. Entry Date: 20070706. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Hip Dislocation, Congenital -- Diagnosis
KW - Diagnosis, Differential
KW - Education, Continuing (Credit)
KW - Infant, Newborn
KW - Male
SP - 1005
EP - 919
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 74
IS - 6
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Preventive Services Task Force Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 17002037.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cooke, Catherine E.
AU - Bresette, James L.
AU - Khanna, Rozina
T1 - Statin use in American Indians and Alaska Natives with coronary artery disease.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2006/09/15/
VL - 63
IS - 18
M3 - Article
SP - 1717
EP - 1722
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The use and adherence to statin therapy in American Indians and Alaska Natives with coronary artery disease (CAD) were studied. Methods. A retrospective database analysis of the Phoenix Area of the Indian Health Service was conducted. For the cohort of patients with CAD, prescription data were obtained for all statins during calendar year 2003. Use was determined by the presence of at least one statin prescription, whereas adherence was assessed using the medication possession ratio (MPR), persistence, and median gap. Results. The study cohort was composed of 2095 adults (55.6% men) with at least one medical encounter for CAD during calendar year 2002. The mean ± S.D. age of the cohort was 62.7 ± 12.7 years. At least one prescription for any statin drug during 2003 was found for 865 (41.3%) patients. Those who received a statin were more likely to be male, be younger than 80 years, and have a greater number of medical visits. The mean MPR was 0.78 ± 0.25, and nonadherence was found in approximately 40% of patients receiving statins. In the age category of 65-79 years, men were more adherent than women, and patients in this category were overall more adherent than younger patients. Conclusion. The use of statins in a cohort of American Indians and Alaska Natives at high risk for cardiovascular events was approximately 40% with a 60% adherence rate. Age, sex, and number of medical visits were associated with statin use, and age and sex were associated with adherence. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATINS (Cardiovascular agents)
KW - HEART -- Blood-vessels
KW - CORONARY arteries
KW - ANTILIPEMIC agents
KW - PATIENTS
KW - THERAPEUTICS
KW - UNITED States
KW - Age
KW - Antilipemic agents
KW - Compliance
KW - Coronary disease
KW - Drug use
KW - Ethnic groups
KW - Patients
KW - Sex
N1 - Accession Number: 22332916; Cooke, Catherine E. 1,2; Email Address: cecookel@hotmail.com Bresette, James L. 3 Khanna, Rozina 4; Affiliation: 1: Clinical Education Consultant, Pfizer U.S. Pharmaceuticals, Ellicott City, MD. 2: Clinical Assistant Professor, Department of Pharmacy Practice and Science (DPPS), School of Pharmacy, University of Maryland (UM), Baltimore. 3: Deputy Director, Office of Clinical and Preventive Services, Indian Health Service Headquarters, Rockville, MD. 4: Manager, Virology Medical Strategy, Bristol-Myers Squibb, Plainsboro, NJ.; Source Info: 9/15/2006, Vol. 63 Issue 18, p1717; Subject Term: STATINS (Cardiovascular agents); Subject Term: HEART -- Blood-vessels; Subject Term: CORONARY arteries; Subject Term: ANTILIPEMIC agents; Subject Term: PATIENTS; Subject Term: THERAPEUTICS; Subject Term: UNITED States; Author-Supplied Keyword: Age; Author-Supplied Keyword: Antilipemic agents; Author-Supplied Keyword: Compliance; Author-Supplied Keyword: Coronary disease; Author-Supplied Keyword: Drug use; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: Patients; Author-Supplied Keyword: Sex; Number of Pages: 6p; Document Type: Article
L3 - 10.2146/ajhp050517
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tryndyak, Volodymyr
AU - Kovalchuk, Olga
AU - Pogribny, Igor P.
T1 - Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2006/09/15/
VL - 356
IS - 2
M3 - Article
SP - 202
EP - 207
SN - 00032697
AB - Abstract: Altered DNA methylation has been linked to neoplastic cell transformation and is a hallmark of cancer progression. Therefore, the screening for differentially methylated sequences as tumor biomarkers has a significant implication in the clinical setting. To determine the cancer-linked alterations in DNA methylation pattern, we have applied an endonuclease, McrBC, to the existing methylation-sensitive arbitrarily primed polymerase chain reaction (msAP-PCR) method and developed McrBC-msAP-PCR. This modified approach allows detection of differentially methylated sites within unmethylated DNA domains enriched by regulatory sequences and CpG islands. In this method, we used digestion of DNA with the McrBC methylation-sensitive endonuclease to selectively exclude the methylated fraction of DNA, which comprises interspersed and tandem-repeated sequences and exons other than first exons, from analysis. The subsequent digestion of unmethylated DNA fragments with SmaI and HpaII methylation-sensitive restriction endonucleases followed by AP-PCR amplification resulted in the detection of unknown unique sequences associated with cancer-linked methylation changes in genomic DNA. Hypermethylation and hypomethylation are visualized by the increase or decrease in the band intensity of DNA fingerprints. By using this technique, we were able to differentiate clearly, identify, and characterize a number of novel unique DNA sequences with differentially methylated sites in normal and breast cancer cell lines and in normal and rat tumor liver tissues. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER cells
KW - DNA
KW - METHYLATION
KW - BIOCHEMICAL markers
KW - Cancer
KW - Detection
KW - DNA methylation
KW - Hypermethylation
N1 - Accession Number: 22213071; Tryndyak, Volodymyr 1 Kovalchuk, Olga 2 Pogribny, Igor P. 1; Email Address: ipogribny@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4; Source Info: Sep2006, Vol. 356 Issue 2, p202; Subject Term: CANCER cells; Subject Term: DNA; Subject Term: METHYLATION; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Detection; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Hypermethylation; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ab.2006.05.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Engel, Eva
AU - Santarelli, Francesco
AU - Vasold, Rudolf
AU - Ulrich, Heidi
AU - Maisch, Tim
AU - König, Burkhard
AU - Landthaler, Michael
AU - Gopee, Neera V.
AU - Paul C. Howard
AU - Wolfgang Bäumler
T1 - Establishment of an Extraction Method for the Recovery of Tattoo Pigments from Human Skin Using HPLC Diode Array Detector Technology.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2006/09/15/
VL - 78
IS - 18
M3 - Article
SP - 6440
EP - 6447
SN - 00032700
AB - Tattooing is a widespread process of puncturing pigments into skin, whereas the resulting concentration inside the skin remains unknown. Many tattoo colorants are organic pigments, such as azo pigments, manufactured for other uses. To remove tattoos from skin, laser pulses at very high intensifies are applied to the skin to destroy the tattoo pigments. Recent investigations have shown that several azo compounds are cleaved by laser light leading to potentially toxic or carcinogenic compounds. To assess the risk of tattooing and laser treatment of tattoos, the concentration of the pigments and their decomposition products in the skin must be determined. Therefore, an extraction method was established to determine the concentration of tattoo pigments and decomposition products quantitatively. The extraction of two widely used azo compounds, Pigment Red 22 and Pigment Red 9, and their laser-induced decomposition products, 2-methyl-5-nitroaniline, 4-nitrotoluene, 2,5-dichloraniline, and 1,4-dichlorobenzene, was accomplished using recovery experiments and HPLC-DAD technology. Despite the poor solubility of the pigments, a nearly complete recovery from aqueous suspension (>92%) or lysed skin (>94%)was achieved. The decomposition products were extracted from aqueous suspension or skin showing a recovery of up to 100%, except for the very volatile 1,4-DCB. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TATTOOING
KW - HUMAN skin color
KW - AZO compounds
KW - HIGH performance liquid chromatography
KW - CARCINOGENICITY
KW - LASER beams
KW - DETECTORS
KW - BODY marking
KW - ANALYTICAL chemistry
N1 - Accession Number: 22550735; Engel, Eva 1 Santarelli, Francesco 2 Vasold, Rudolf 1 Ulrich, Heidi 2 Maisch, Tim 2 König, Burkhard 1 Landthaler, Michael 2 Gopee, Neera V. 3 Paul C. Howard 3 Wolfgang Bäumler 2; Email Address: baeumler.wolfgang@klinik.uni-regensburg.de; Affiliation: 1: Department of Organic Chemistry, University of Regensburg 2: Department of Dermatology, University of Regensburg 3: U.S. Food and Drug Administration; Source Info: 9/15/2006, Vol. 78 Issue 18, p6440; Subject Term: TATTOOING; Subject Term: HUMAN skin color; Subject Term: AZO compounds; Subject Term: HIGH performance liquid chromatography; Subject Term: CARCINOGENICITY; Subject Term: LASER beams; Subject Term: DETECTORS; Subject Term: BODY marking; Subject Term: ANALYTICAL chemistry; Number of Pages: 8p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Troiano, Carolyn
AU - Boyce, Cam
AU - Arbogast, Steven
AU - Fulton, Steven
AU - Booth, Jim
AU - Freeze, Terry
AU - Burbary, Ken
AU - Thibodeau, Ryan
T1 - InBox.
JO - CIO
JF - CIO
Y1 - 2006/09/15/
VL - 19
IS - 23
M3 - Letter
SP - 18
EP - 20
SN - 08949301
AB - Several letters to the editor in response to articles discussed in previous issues are presented, including "Communicating IT's Value: Tools and Tactics," on the August 1, 2006 issue, "How to Align IT With Business Innovation," in the August 1, 2006 issue, and "China Builds a Better Internet," in the July 15, 2006 issue.
KW - INFORMATION technology
KW - BUSINESS
KW - INTERNET
KW - TECHNOLOGY
KW - LETTERS to the editor
N1 - Accession Number: 22811354; Troiano, Carolyn; Boyce, Cam 1; Arbogast, Steven 2; Fulton, Steven 3; Booth, Jim 4; Freeze, Terry 5; Email Address: t.freeze@nsai.com; Burbary, Ken 6; Email Address: kburbary@campbell-ewald.com; Thibodeau, Ryan 7; Affiliations: 1: Communications Director, Office of the Chief Information Officer, Food and Drug Administration; 2: President, QualiWare Inc.; 3: Director, Fidelity Investments; 4: CIO, Spectre Systems Inc.; 5: CIO, National Safety Associates LLC; 6: Senior Vice President, Director of Engineering, Campbell Ewald; 7: IT Manager, Athens Banner-Herald; Issue Info: 9/15/2006, Vol. 19 Issue 23, p18; Thesaurus Term: INFORMATION technology; Thesaurus Term: BUSINESS; Thesaurus Term: INTERNET; Thesaurus Term: TECHNOLOGY; Subject Term: LETTERS to the editor; NAICS/Industry Codes: 517110 Wired Telecommunications Carriers; NAICS/Industry Codes: 519130 Internet Publishing and Broadcasting and Web Search Portals; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Audet, Susette
AU - Virata-Theimer, Maria Luisa
AU - Beeler, Judy A.
AU - Scott, Dorothy E.
AU - Frazier, Douglas J.
AU - Mikolajczyk, Malgorzata G.
AU - Eller, Nancy
AU - Feng-Ming Chen
AU - Yu, Mei-Ying W.
T1 - Measles-Virus--Neutralizing Antibodies in Intravenous Immunoglobulins.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/09/15/
VL - 194
IS - 6
M3 - Article
SP - 781
EP - 789
SN - 00221899
AB - Measles infection induces lifelong immunity; however, wild-type infection stimulates higher levels of measles-virus-neutralizing antibodies (mnAbs) than does vaccination. Because the proportion of the donor population with vaccine-induced measles immunity is increasing, this study was conducted to determine whether this shift in demographic characteristics affects mnAb levels in contemporary lots of Immune Globulin Intravenous (Human) (IGIV). When 166 lots of 7 IGIV products manufactured between 1998 and 2003 were assayed by plaque-reduction neutralization test, there was a progressive decrease in geometric mean titers in lots manufactured between 1999 and 2002. IGIV products manufactured from recovered plasma had significantly higher titers than did those manufactured from Source Plasma, which could reflect a change in donor demographic characteristics, because Source Plasma donors tend to be much younger. A reduction in mnAbs also correlated with the loss of either IgG1 and IgG3, possibly because of certain manufacturing procedures, or bivalent antibodies (i.e., intact IgG and F(ab′)2), because of fragmentation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEASLES virus
KW - IMMUNOGLOBULINS
KW - IMMUNITY
KW - VACCINATION
KW - COMMUNICABLE diseases
N1 - Accession Number: 22055501; Audet, Susette 1 Virata-Theimer, Maria Luisa 2 Beeler, Judy A. 1 Scott, Dorothy E. 2 Frazier, Douglas J. 2 Mikolajczyk, Malgorzata G. 2 Eller, Nancy 2 Feng-Ming Chen 2 Yu, Mei-Ying W. 2; Email Address: mei-ying.yu@fda.hhs.gov; Affiliation: 1: Divisions of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Department of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: 9/15/2006, Vol. 194 Issue 6, p781; Subject Term: MEASLES virus; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNITY; Subject Term: VACCINATION; Subject Term: COMMUNICABLE diseases; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dragunsky, Eugenia M.
AU - Ivanov, Alexander P.
AU - Abe, Shinobu
AU - Potapova, Svetlana G.
AU - Enterline,, Joan C.
AU - Hashizume, So
AU - Chumakov, Konstantin M.
T1 - Further Development of a New Transgenic Mouse Test for the Evaluation of the Immunogenicity and Protective Properties of Inactivated Poliovirus Vaccine.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2006/09/15/
VL - 194
IS - 6
M3 - Article
SP - 804
EP - 807
SN - 00221899
AB - Recently, we developed and optimized a new method for the evaluation of the protective properties of serotype 2 inactivated poliovirus vaccines (IPV). The method is based on the immunization and subsequent challenge of transgenic (Tg) mice susceptible to poliovirus. We describe a similar method for the assessment of the protectiveness of serotype 1 IPV and demonstrate that experimental IPV produced from attenuated Sabin strain (sIPV) of serotype 1 poliovirus induced serum neutralizing antibodies, immunoglobulin (Ig) G, IgM, and salivary IgA at titers comparable to those induced by conventional IPV (cIPV) produced from the wild-type Mahoney strain. In contrast to our previous results with serotype 2 sIPV, serotype 1 sIPV provided even better protection of Tg mice than cIPV against challenge with wild-type Mahoney strain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIOVIRUS
KW - VACCINATION
KW - TRANSGENIC mice
KW - IMMUNIZATION
KW - SERUM
N1 - Accession Number: 22055504; Dragunsky, Eugenia M. 1; Email Address: eugenia.dragunsky@fda.hhs.gov Ivanov, Alexander P. 1 Abe, Shinobu 2 Potapova, Svetlana G. 1 Enterline,, Joan C. 1 Hashizume, So 2 Chumakov, Konstantin M. 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 2: Poliomyelitis Research Institute, Tokyo, Japan; Source Info: 9/15/2006, Vol. 194 Issue 6, p804; Subject Term: POLIOVIRUS; Subject Term: VACCINATION; Subject Term: TRANSGENIC mice; Subject Term: IMMUNIZATION; Subject Term: SERUM; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106352299
T1 - Measles-virus-neutralizing antibodies in intravenous immunoglobulins.
AU - Audet S
AU - Virata-Theimer ML
AU - Beeler JA
AU - Scott DE
AU - Frazier DJ
AU - Mikolajczyk MG
AU - Eller N
AU - Chen F
AU - Yu MW
Y1 - 2006/09/15/
N1 - Accession Number: 106352299. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Antibodies, Viral -- Blood
KW - Immunoglobulins, Intravenous -- Analysis
KW - Measles -- Immunology
KW - Blood Donors
KW - Chemistry, Pharmaceutical
KW - Immunoglobulins, Intravenous -- Administration and Dosage
KW - Immunoglobulins, Intravenous -- Standards
KW - Immunoglobulins, Intravenous -- Therapeutic Use
KW - Measles -- Prevention and Control
KW - T-Tests
KW - Time Factors
KW - Human
SP - 781
EP - 789
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 194
IS - 6
PB - Oxford University Press / USA
AB - Measles infection induces lifelong immunity; however, wild-type infection stimulates higher levels of measles-virus-neutralizing antibodies (mnAbs) than does vaccination. Because the proportion of the donor population with vaccine-induced measles immunity is increasing, this study was conducted to determine whether this shift in demographic characteristics affects mnAb levels in contemporary lots of Immune Globulin Intravenous (Human) (IGIV). When 166 lots of 7 IGIV products manufactured between 1998 and 2003 were assayed by plaque-reduction neutralization test, there was a progressive decrease in geometric mean titers in lots manufactured between 1999 and 2002. IGIV products manufactured from recovered plasma had significantly higher titers than did those manufactured from Source Plasma, which could reflect a change in donor demographic characteristics, because Source Plasma donors tend to be much younger. A reduction in mnAbs also correlated with the loss of either IgG1 and IgG3, possibly because of certain manufacturing procedures, or bivalent antibodies (i.e., intact IgG and F(ab')(2)), because of fragmentation. Copyright © 2006 Infectious Diseases Society of America
SN - 0022-1899
AD - Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
U2 - PMID: 16941344.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106352299&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106352302
T1 - Further development of a new transgenic mouse test for the evaluation of the immunogenicity and protective properties of inactivated poliovirus vaccine.
AU - Dragunsky EM
AU - Ivanov AP
AU - Abe S
AU - Potapova SG
AU - Enterline JC
AU - Hashizume S
AU - Chumakov KM
Y1 - 2006/09/15/
N1 - Accession Number: 106352302. Language: English. Entry Date: 20061027. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: National Vaccine Program Office (grant 224-95-1247). NLM UID: 0413675.
KW - Drug Evaluation -- Methods
KW - Poliomyelitis -- Prevention and Control
KW - Poliovirus Vaccine, Inactivated -- Immunology
KW - Animal Studies
KW - Antibodies, Viral -- Blood
KW - Correlation Coefficient
KW - Drugs, Investigational
KW - Enzyme-Linked Immunosorbent Assay
KW - Funding Source
KW - Immunoglobulins
KW - Mice
KW - Poliovirus Vaccine, Inactivated -- Administration and Dosage
KW - Poliovirus Vaccine, Inactivated -- Analysis
KW - Poliovirus Vaccine, Inactivated -- Therapeutic Use
KW - Regression
KW - Vaccine Failure
SP - 804
EP - 807
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 194
IS - 6
PB - Oxford University Press / USA
AB - Recently, we developed and optimized a new method for the evaluation of the protective properties of serotype 2 inactivated poliovirus vaccines (IPV). The method is based on the immunization and subsequent challenge of transgenic (Tg) mice susceptible to poliovirus. We describe a similar method for the assessment of the protectiveness of serotype 1 IPV and demonstrate that experimental IPV produced from attenuated Sabin strain (sIPV) of serotype 1 poliovirus induced serum neutralizing antibodies, immunoglobulin (Ig) G, IgM, and salivary IgA at titers comparable to those induced by conventional IPV (cIPV) produced from the wild-type Mahoney strain. In contrast to our previous results with serotype 2 sIPV, serotype 1 sIPV provided even better protection of Tg mice than cIPV against challenge with wild-type Mahoney strain. Copyright © 2006 Infectious Diseases Society of America
SN - 0022-1899
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. eugenia.dragunsky@fda.hhs.gov
U2 - PMID: 16941347.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106352302&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Levinson, Daniel R.
T1 - Cost and Performance of Medicare's 2005 Chemotherapy Demonstration Project.
JO - Medical Benefits
JF - Medical Benefits
Y1 - 2006/09/15/
VL - 23
IS - 17
M3 - Article
SP - 11
EP - 11
PB - Aspen Publishers Inc.
SN - 07438079
AB - The article presents information on Medicare's Chemotherapy Demonstration Project for cancer patients undergoing chemotherapy, which was a project of the Centers for Medicare & Medicaid Services of the U.S. initiated in 2005. The aim of the project was to assess and ameliorate the quality of medical care for cancer patients undergoing chemotherapy. Major modifications have been made to the demonstration in 2006.
KW - MEDICAID
KW - CANCER patients
KW - MEDICAL policy
KW - DRUG therapy
KW - UNITED States
KW - CENTERS for Medicare & Medicaid Services (U.S.)
N1 - Accession Number: 22303977; Levinson, Daniel R. 1; Affiliations: 1: Inspector General, US Department of Health and Human Services.; Issue Info: 9/15/2006, Vol. 23 Issue 17, p11; Thesaurus Term: MEDICAID; Subject Term: CANCER patients; Subject Term: MEDICAL policy; Subject Term: DRUG therapy; Subject: UNITED States ; Company/Entity: CENTERS for Medicare & Medicaid Services (U.S.); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1/2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Pearson, Nancy J.
AU - Johnson, Laura Lee
AU - Nahin, Richard L.
T1 - Insomnia, Trouble Sleeping, and Complementary and Alternative Medicine.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2006/09/18/
VL - 166
IS - 16
M3 - Article
SP - 1775
EP - 1782
SN - 00039926
AB - The article reports on the result of the study on the effectiveness of complementary and alternative medicine (CAM) therapies in treating insomnia or trouble sleeping in the U.S. Over 1.6 million civilian, noninstutionalized adult U.S. citizens used CAM to treat insomnia or trouble sleeping, according to the National Health Interview Survey analysis. 17.4 percent is the 12-month prevalence rate of insomnia or trouble sleeping.
KW - ALTERNATIVE medicine
KW - THERAPEUTICS
KW - INSOMNIA
KW - SLEEP disorders
KW - PHARMACEUTICAL research
KW - UNITED States
N1 - Accession Number: 22475288; Pearson, Nancy J. 1 Johnson, Laura Lee 1 Nahin, Richard L. 1; Affiliation: 1: National Center for Complementary and Alternative Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md.; Source Info: 9/18/2006, Vol. 166 Issue 16, p1775; Subject Term: ALTERNATIVE medicine; Subject Term: THERAPEUTICS; Subject Term: INSOMNIA; Subject Term: SLEEP disorders; Subject Term: PHARMACEUTICAL research; Subject Term: UNITED States; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106019851
T1 - Insomnia, trouble sleeping, and complementary and alternative medicine: analysis of the 2002 National Health Interview Survey data.
AU - Pearson NJ
AU - Johnson LL
AU - Nahin RL
Y1 - 2006/09/18/
N1 - Accession Number: 106019851. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0372440.
KW - Alternative Therapies -- Utilization
KW - Insomnia -- Prevention and Control
KW - Adolescence
KW - Adult
KW - Demography
KW - Aged
KW - Aged, 80 and Over
KW - Anxiety -- Epidemiology
KW - Attitude to Health
KW - Population
KW - Depression -- Epidemiology
KW - Educational Status
KW - Female
KW - Surveys
KW - Heart Failure -- Epidemiology
KW - Hypertension -- Epidemiology
KW - Male
KW - Middle Age
KW - Obesity -- Epidemiology
KW - Insomnia -- Epidemiology
KW - United States
SP - 1775
EP - 1782
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
JA - ARCH INTERN MED
VL - 166
IS - 16
CY - Chicago, Illinois
PB - American Medical Association
SN - 0003-9926
AD - National Center for Complementary and Alternative Medicine, National Institutes of Health, US Department of Health and Human Services, 6707 Democracy Blvd, Suite 401, Bethesda, MD 20892-5475; pearsonn@mail.nih.gov
U2 - PMID: 16983058.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106019851&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Banks, David
T1 - Lessons from Hurricane Rita: Organizing to Provide Medical Care during a Natural Disaster.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2006/09/19/
VL - 145
IS - 6
M3 - Editorial
SP - 468
EP - W134
SN - 00034819
AB - The author discusses some lessons coming from the officers of the U.S. Public Health Service to inform the importance of medical care during the time of natural disaster. He argues that providing medical care to the victims of natural disaster is a great help especially to the victims of Hurricane Rita in Louisiana. An overview on the supports made by several officers like the Commissioned Corps officers who work voluntarily in the Gulf Coast to serve as physicians or veterinarian is offered.
KW - MEDICAL care
KW - NATURAL disasters
KW - EMERGENCY management
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 22444745; Banks, David 1; Email Address: walsht@mail.nih.gov; Affiliation: 1: U.S. Food and Drug Administration Rockville, MD 20833; Source Info: 9/19/2006, Vol. 145 Issue 6, p468; Subject Term: MEDICAL care; Subject Term: NATURAL disasters; Subject Term: EMERGENCY management; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roscoe, RJ
AU - Graydon, JR
T1 - Adult Blood Lead Epidemiology and Surveillance--United States, 2003-2004.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/09/20/
VL - 296
IS - 11
M3 - Article
SP - 1346
EP - 1347
SN - 00987484
AB - The article describes the Centers for Disease Control and Prevention's state-based Adult Blood Lead Epidemiology and Surveillance (ABLES) program. A public health objective of ABLES is to reduce the prevalence of elevated blood lead levels (BLL) in employed adults to zero by 2010. The article describes the changes in the analytic methods of ABLES. The report mentions the occupational sources of lead exposure, including the manufacture of storage batteries, painting, paperhanging and decorating, and the mining of lead ores. Nonoccupational sources of exposure include shooting firearms, remodeling or renovation activities, and hobbies. The article states that the prevalence of elevated BLLs has decreased since 1994. The article describes limitations to the report issued by ABLES.
KW - LEAD -- Toxicology
KW - LEAD poisoning -- Prevention
KW - PUBLIC health surveillance
KW - EPIDEMIOLOGY -- Research
KW - BLOOD analysis
KW - BATTERY industry
KW - EMPLOYEES
KW - PUBLIC health research
KW - OCCUPATIONAL hazards
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 22406109; Roscoe, RJ 1 Graydon, JR 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDD; Source Info: 9/20/2006, Vol. 296 Issue 11, p1346; Subject Term: LEAD -- Toxicology; Subject Term: LEAD poisoning -- Prevention; Subject Term: PUBLIC health surveillance; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: BLOOD analysis; Subject Term: BATTERY industry; Subject Term: EMPLOYEES; Subject Term: PUBLIC health research; Subject Term: OCCUPATIONAL hazards; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Malarkey, M
AU - Solomon, R
AU - Witten, C
AU - Bloom, E
AU - Wells, M
AU - Braun, M
AU - Wise, R
AU - Zinderman, C
AU - Jernigan, DB
AU - Kuehnert, MJ
AU - Srinivasan, A
AU - Wang, S
T1 - Brief Report: Investigation into Recalled Human Tissue for Transplantation-- United States, 2005-2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/09/20/
VL - 296
IS - 11
M3 - Report
SP - 1347
EP - 1348
SN - 00987484
AB - The article reports that human tissue-processing company Biomedical Tissue Services Ltd. (BTS) recovered tissues from human donors who were not screened properly for certain infectious diseases and who might not have met donor eligibility requirements. The tissues were sent to five processors and distributed to all 50 states and other nations. The U.S. Food and Drug Administration, along with BTS and tissue processors who received the suspect tissues, issued a recall of all BTS recovered tissues. In its tissue recovery processes, BTS violated the Current Good Tissue Practice Rules, which has rules to prevent the introduction, transmission, or spread of communicable diseases. Transmission of infection via tissue allografts is rare, but still documented.
KW - DONATION of organs, tissues, etc.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - TISSUE culture
KW - HOMOGRAFTS
KW - COMMUNICABLE diseases
KW - CORRUPT practices
KW - RISK factors
KW - BIOMEDICAL Tissue Services Ltd.
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 22406112; Malarkey, M 1 Solomon, R 1 Witten, C 1 Bloom, E 1 Wells, M 1 Braun, M 1 Wise, R 1 Zinderman, C 1 Jernigan, DB 2 Kuehnert, MJ 2 Srinivasan, A 2 Wang, S; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration 2: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases; Source Info: 9/20/2006, Vol. 296 Issue 11, p1347; Subject Term: DONATION of organs, tissues, etc.; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: TISSUE culture; Subject Term: HOMOGRAFTS; Subject Term: COMMUNICABLE diseases; Subject Term: CORRUPT practices; Subject Term: RISK factors; Company/Entity: BIOMEDICAL Tissue Services Ltd. Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 2p; Document Type: Report
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RUDER, AVIMA M.
T1 - Potential Health Effects of Occupational Chlorinated Solvent Exposure.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/09/21/
VL - 1076
IS - 1
M3 - Article
SP - 207
EP - 227
SN - 00778923
AB - Based on toxicology, metabolism, animal studies, and human studies, occupational exposure to chlorinated aliphatic solvents (methanes, ethanes, and ethenes) has been associated with numerous adverse health effects, including central nervous system, reproductive, liver, and kidney toxicity, and carcinogenicity. However, many of these solvents remain in active, large-volume use. This article reviews the recent occupational epidemiology literature on the most widely used solvents, methylene chloride, chloroform, trichloroethylene, and tetrachloroethylene, and discusses other chlorinated aliphatics. The impact of studies to date has been lessened because of small study size, inability to control for confounding factors, particularly smoking and mixed occupational exposures, and the lack of evidence for a solid pathway from occupational exposure to biological evidence of exposure, to precursors of health effects, and to health effects. International differences in exposure limits may provide a “natural experiment” in the coming years if countries that have lowered exposure limits subsequently experience decreased adverse health effects among exposed workers. Such decreases could provide some evidence that higher levels of adverse health effects were associated with higher levels of solvent exposure. The definitive studies, which should be prospective biomarker studies incorporating body burden of solvents as well as markers of effect, remain to be done. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - PUBLIC health
KW - METABOLISM
KW - SOLVENTS
KW - EPIDEMIOLOGY
KW - DISEASES
KW - cancer
KW - chlorinated solvents
KW - health effects
KW - occupational exposure
KW - tetrachloroethylene
KW - trichloroethylene
N1 - Accession Number: 23150391; RUDER, AVIMA M. 1; Email Address: amr2@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA; Source Info: 2006, Vol. 1076 Issue 1, p207; Subject Term: TOXICOLOGY; Subject Term: PUBLIC health; Subject Term: METABOLISM; Subject Term: SOLVENTS; Subject Term: EPIDEMIOLOGY; Subject Term: DISEASES; Author-Supplied Keyword: cancer; Author-Supplied Keyword: chlorinated solvents; Author-Supplied Keyword: health effects; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: tetrachloroethylene; Author-Supplied Keyword: trichloroethylene; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 21p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1196/annals.1371.050
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Devi, Sachin S.
AU - Philip, Binu K.
AU - Warbritton, Alan
AU - Latendresse, John R.
AU - Mehendale, Harihara M.
T1 - Prior administration of a low dose of thioacetamide protects type 1 diabetic rats from subsequent administration of lethal dose of thioacetamide
JO - Toxicology
JF - Toxicology
Y1 - 2006/09/21/
VL - 226
IS - 2/3
M3 - Article
SP - 107
EP - 117
SN - 0300483X
AB - Abstract: Previously, we reported that an ordinarily non-lethal dose of thioacetamide (TA, 300mg/kg) causes 90% mortality in type 1 diabetic rats due to inhibited liver tissue repair, whereas 30mg TA/kg allows 100% survival due to stimulated although delayed tissue repair. Objective of this investigation was to test whether prior administration of a low dose of TA (30mg/kg) would lead to sustainable stimulation of liver tissue repair in type 1 diabetic rats sufficient to protect from a subsequently administered lethal dose of TA. Therefore, in the present study, the hypothesis that preplacement of tissue repair by a low dose of TA (30mg TA/kg, ip) can reverse the hepatotoxicant sensitivity (autoprotection) in type 1 diabetic rats was tested. Preliminary studies revealed that a single intraperitoneal (ip) administration of TA causes 90% mortality in diabetic rats with as low as 75mg/kg. To establish an autoprotection model in diabetic condition, diabetic rats were treated with 30mg TA/kg (priming dose). Administration of priming dose stimulated tissue repair that peaked at 72h, at which time these rats were treated with a single ip dose of 75mg TA/kg. Our results show that tissue repair stimulated by the priming dose enabled diabetic rats to overexpress, calpastatin, endogenous inhibitor of calpain, to inhibit calpain-mediated progression of liver injury induced by the subsequent administration of lethal dose, resulting in 100% survival. Further investigation revealed that protection observed in these rats is not due to decreased bioactivation. These studies underscore the importance of stimulation of tissue repair in the final outcome of liver injury (survival/death) after hepatotoxicant challenge. Furthermore, these results also suggest that it is possible to stimulate tissue repair in diabetics to overcome the enhanced sensitivity of hepatotoxicants. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETICS
KW - BILIARY tract
KW - ENDOCRINE diseases
KW - CARBOHYDRATE intolerance
KW - Hepatotoxicity
KW - Liver
KW - Thioacetamide
KW - Tissue repair
KW - Type 1 diabetes
N1 - Accession Number: 22134934; Devi, Sachin S. 1 Philip, Binu K. 1 Warbritton, Alan 2 Latendresse, John R. 2 Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliation: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Ave, Monroe, LA 71209, USA 2: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Sep2006, Vol. 226 Issue 2/3, p107; Subject Term: DIABETICS; Subject Term: BILIARY tract; Subject Term: ENDOCRINE diseases; Subject Term: CARBOHYDRATE intolerance; Author-Supplied Keyword: Hepatotoxicity; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Thioacetamide; Author-Supplied Keyword: Tissue repair; Author-Supplied Keyword: Type 1 diabetes; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.tox.2006.06.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soumerai, Stephen B.
AU - Pierre-Jacques, Marsha
AU - Fang Zhang
AU - Ross-Degnan, Dennis
AU - Adams, Alyce S.
AU - Gurwitz, Jerry
AU - Adler, Gerald
AU - Safran, Dana Gelb
T1 - Cost-Related Medication Nonadherence Among Elderly and Disabled Medicare Beneficiaries.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2006/09/25/
VL - 166
IS - 17
M3 - Article
SP - 1801
EP - 1835
SN - 00039926
AB - The article investigates the prevalence of cost-related medication nonadherence (CRN) among elderly and non-elderly disabled Medicare beneficiaries and the relations of socioeconomic status, prescription drug coverage, and the burden of chronic illness with CRN in the United States. Rates of CRN are highest among nonelderly disabled beneficiaries. However, CRN is exacerbated by poor health, multiple morbidities, and limited drug coverage among both elderly and disabled beneficiaries.
KW - PATIENT compliance
KW - COST
KW - OLDER people
KW - HEALTH behavior
KW - MEDICARE
KW - SOCIAL status
KW - UNITED States
N1 - Accession Number: 22610116; Soumerai, Stephen B. 1 Pierre-Jacques, Marsha 1 Fang Zhang 1 Ross-Degnan, Dennis 1 Adams, Alyce S. 1 Gurwitz, Jerry 2 Adler, Gerald 3 Safran, Dana Gelb 4; Affiliation: 1: Department of Ambulatory Care and Prevention, Harvard Medical School & Harvard Pilgrim Health Care, Boston, Mass 2: Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester 3: Centres for Medicare and Medicaid Services, US Department of Health and Human Services, Baltimore. Md 4: The Health Institute at Tufts—New England Medical Center and Tufts University School of Medicine Boston; Source Info: 9/25/2006, Vol. 166 Issue 17, p1801; Subject Term: PATIENT compliance; Subject Term: COST; Subject Term: OLDER people; Subject Term: HEALTH behavior; Subject Term: MEDICARE; Subject Term: SOCIAL status; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mannheimer, S. B.
AU - Mukherjee, R.
AU - Hirschhorn, L. R.
AU - Dougherty, J.
AU - Celano, S. A.
AU - Ciccarone, D.
AU - Graham, K. K.
AU - Mantell, J. E.
AU - Mundy, L. M.
AU - Eldred, L.
AU - Botsko, Michael
AU - Finkelstein, R.
T1 - The CASE adherence index: A novel method for measuring adherence to antiretroviral therapy.
JO - AIDS Care
JF - AIDS Care
Y1 - 2006/10//
VL - 18
IS - 7
M3 - Article
SP - 853
EP - 861
PB - Routledge
SN - 09540121
AB - The Center for Adherence Support Evaluation (CASE) Adherence Index, a simple composite measure of self-reported antiretroviral therapy (ART) adherence, was compared to a standard three-day self-reported adherence measure among participants in a longitudinal, prospective cross-site evaluation of 12 adherence programs throughout the United States. The CASE Adherence Index, consisting of three unique adherence questions developed for the cross-site study, along with a three-day adherence self-report were administered by interviews every three months over a one-year period. Data from the three cross-site adherence questions (individually and in combination) were compared to three -day self-report data and HIV RNA and CD4 outcomes in cross-sectional analyses. The CASE Adherence Index correlated strongly with the three-day self-reported adherence data ( p 10 achieved a 98 cell mean increase in CD4 count over 12 months, compared to a 41 cell increase for those with scores ≤10 ( p [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Care is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATIENT compliance
KW - PATIENT participation
KW - ANTIVIRAL agents
KW - VIRUS diseases -- Drug therapy
KW - LONGITUDINAL method
KW - THERAPEUTICS
KW - UNITED States
N1 - Accession Number: 22306513; Mannheimer, S. B. 1 Mukherjee, R. 2 Hirschhorn, L. R. 3 Dougherty, J. 4 Celano, S. A. 5 Ciccarone, D. 6 Graham, K. K. 7 Mantell, J. E. 2 Mundy, L. M. 8 Eldred, L. 9 Botsko, Michael 2; Email Address: mbotsko@nyam.org Finkelstein, R. 2; Affiliation: 1: Harlem Hospital Center, Columbia University, New York, NY 2: New York Academy of Medicine, New York, NY 3: Harvard Medical School Division of AIDS, Boston, MA 4: Multnomah County Health Department, Portland, OR 5: Johns Hopkins University School of Medicine, Baltimore, MD 6: University of California, San Francisco, San Francisco, CA 7: North Broward Hospital District, Nova Southeastern University, Ft. Lauderdale, FL 8: Washington University School of Medicine, St. Louis, MO 9: Health Resources and Services Administration, HIV/AIDS Bureau, SPNS/Office of Science and Epidemiology, Rockville, MD, USA; Source Info: Oct2006, Vol. 18 Issue 7, p853; Subject Term: PATIENT compliance; Subject Term: PATIENT participation; Subject Term: ANTIVIRAL agents; Subject Term: VIRUS diseases -- Drug therapy; Subject Term: LONGITUDINAL method; Subject Term: THERAPEUTICS; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/09540120500465160
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Niemtzow, Richard C.
AU - Gambel, Jeffrey
AU - Helms, Joseph
AU - Pock, Arnyce
AU - Burns, Stephen M.
AU - Baxter, John
T1 - Integrating Ear and Scalp Acupuncture Techniques into the Care of Blast-Injured United States Military Service Members with Limb Loss.
JO - Alternative & Complementary Therapies
JF - Alternative & Complementary Therapies
Y1 - 2006/10//
VL - 12
IS - 5
M3 - Article
SP - 244
EP - 246
SN - 10762809
AB - The article discusses the plans to implement practice of alternative therapy "Acupuncture," in the medical services of US Armed forces to cure the war injured servicemen. The article discusses its historical background and its widespread civilian society. The article cites few instances where ear and scalp acupuncture has reduced battlefield wound induced pain.
KW - ACUPUNCTURE
KW - ALTERNATIVE medicine
KW - MILITARY medicine
KW - ARMED Forces
KW - MILITARY personnel -- Wounds & injuries
KW - MEDICINE -- Practice
KW - UNITED States
N1 - Accession Number: 22657924; Niemtzow, Richard C. 1 Gambel, Jeffrey 2 Helms, Joseph 3 Pock, Arnyce 4 Burns, Stephen M. 5 Baxter, John 6; Affiliation: 1: Acupuncture Clinic, Malcolm Grow Medical Center, Andrews Air Force Base, Maryland 2: Physical Medicine & Rehabilitation Service, Walter Reed Army Medical Center, Washington, D.C. 3: Helms Medical Institute, Stanford University School of Medicine, Berkeley, California 4: USAF Medical Corps, Office of the Surgeon General, Bolling Air Force Base, Washington, D.C. 5: Acupuncture Clinic, Malcolm Grow Medical Center, Andrews Air Force Base 6: Pentagon Flight Medicine Clinic, Pentagon, Washington, D.C.; Source Info: Oct2006, Vol. 12 Issue 5, p244; Subject Term: ACUPUNCTURE; Subject Term: ALTERNATIVE medicine; Subject Term: MILITARY medicine; Subject Term: ARMED Forces; Subject Term: MILITARY personnel -- Wounds & injuries; Subject Term: MEDICINE -- Practice; Subject Term: UNITED States; NAICS/Industry Codes: 928110 National Security; Number of Pages: 3p; Illustrations: 5 Black and White Photographs; Document Type: Article
L3 - 10.1089/act.2006.12.244
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiaqiong Xu
AU - Eilat-Adar, Sigal
AU - Loria, Catherine
AU - Goldbourt, Uri
AU - Howard, Barbara V.
AU - Fabsitz, Richard R.
AU - Zephier, Ellie M.
AU - Mattil, Claudia
AU - Lee, Elisa T.
T1 - Dietary fat intake and risk of coronary heart disease: the Strong Heart Study.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2006/10//
VL - 84
IS - 4
M3 - Article
SP - 894
EP - 902
SN - 00029165
AB - Background: The results of previous studies on the association between dietary fat intake and coronary heart disease (CHD) incidence are inconsistent. Objective: The aim of this study was to examine the association between dietary fat intake and CHD incidence in American Indians in the Strong Heart Study. Design: A total of 2938 participants aged 47-79 y and free of CHD at the second examination (1993-1995) were examined and followed for CHD, nonfatal CHD, and fatal CHD events to 31 December 2002. Dietary intake was assessed by using a 24-h diet recall and was calculated as percentages of energy. Results: Participants were followed for a mean (±SD) of 7.2 ± 2.3 y. During follow-up, 436 incidentCHDcases (298 nonfatalCHD and 138 fatal CHD events) were ascertained. Participants aged 47-59 y in the highest quartile of intake of total fat, saturated fatty acids, or monounsaturated fatty acids had higherCHDmortality than did those in the lowest quartile [hazard ratio (95% CI): 3.57 (1.21, 10.49), 5.17 (1.64, 16.36), and 3.43 (1.17, 10.04), respectively] after confounders were controlled for. These associations were not observed for those aged 60-79 y. Conclusions: Total fat, saturated fatty acid, and monounsaturated fatty acid intake were strong predictors of CHD mortality in American Indians aged 47-59 y, independent of other established CHD risk factors. It may be prudent for American Indians to reduce their fat intake early in life to reduce the risk of dying from CHD. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - American Indians
KW - cholesterol
KW - coronary heart disease
KW - Dietary fat intake
KW - fatty acids
KW - mortality
N1 - Accession Number: 94625171; Jiaqiong Xu 1; Email Address: susan-xu@ouhsc.edu; Eilat-Adar, Sigal 2; Loria, Catherine 3; Goldbourt, Uri 4; Howard, Barbara V. 2; Fabsitz, Richard R. 3; Zephier, Ellie M. 5; Mattil, Claudia 2; Lee, Elisa T. 1; Affiliations: 1: Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2: Medstar Research Institute, Hyattsville,MD; 3: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda,MD; 4: Department of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel; 5: Indian Health Service, Aberdeen Area Office, Aberdeen, South Dakota; Issue Info: Oct2006, Vol. 84 Issue 4, p894; Author-Supplied Keyword: American Indians; Author-Supplied Keyword: cholesterol; Author-Supplied Keyword: coronary heart disease; Author-Supplied Keyword: Dietary fat intake; Author-Supplied Keyword: fatty acids; Author-Supplied Keyword: mortality; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Druss, Benjamin G.
AU - Bornemann, Thomas
AU - Fry-Johnson, Yvonne W.
AU - McCombs, Harriet G.
AU - Politzer, Robert M.
AU - Rust, George
T1 - Trends in Mental Health and Substance Abuse Services at the Nation's Community Health Centers: 1998--2003.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/10//
VL - 96
IS - 10
M3 - Article
SP - 1779
EP - 1784
PB - American Public Health Association
SN - 00900036
AB - Objective. We examined trends in delivery of mental health and substance abuse services at the nation's community health centers. Methods, Analyses used data from the Health Resources and Services Administration (HRSA), Bureau of Primary Care's (BPHC) 1998 and 2003 Uniform Data System, merged with county-level data. Results. Between 1998 and 2003, the number of patients diagnosed with a mental health/substance abuse disorder in community health centers increased from 210000 to 800000. There was an increase in the number of patients per specialty mental health/substance abuse treatment provider and a decline in the mean number of patient visits, from 7.3 visits per patient to 3.5 by 2003. Although most community health centers had some on-site mental health/substance abuse services, centers without on-site services were more likely to be located in counties with fewer mental health/substance abuse clinicians, psychiatric emergency rooms, and inpatient hospitals. Conclusions. Community health centers are playing an increasingly central role in providing mental health/substance abuse treatment services in the United States. It is critical both to ensure that these centers have adequate resources for providing mental health/substance abuse care and that they develop effective linkages with mental health/substance abuse clinicians in the communities they serve. (Am J Public Health. 2006;96:1779-1784. doi:10.2105/AJPH.2005.076943) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNITY mental health services
KW - HEALTH facilities
KW - MEDICAL personnel
KW - OUTPATIENT substance abuse treatment facilities
KW - PUBLIC health surveillance
KW - OUTPATIENT mental health facilities
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 22585678; Druss, Benjamin G. 1; Email Address: bdruss@emory.edu Bornemann, Thomas 2 Fry-Johnson, Yvonne W. 3 McCombs, Harriet G. 4 Politzer, Robert M. Rust, George 3; Affiliation: 1: Rollins School of Public Health, Emory University, Atlanta, Ga 2: Carter Center Mental Health Program, Atlanta 3: National Center for Primary Care, Warehouse School of Medicine, Atlanta 4: Health Resources and Services Administration, Bethesda, Md; Source Info: Oct2006, Vol. 96 Issue 10, p1779; Subject Term: COMMUNITY mental health services; Subject Term: HEALTH facilities; Subject Term: MEDICAL personnel; Subject Term: OUTPATIENT substance abuse treatment facilities; Subject Term: PUBLIC health surveillance; Subject Term: OUTPATIENT mental health facilities; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 4912
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106019111
T1 - Consumption of dietary supplements containing Citrus aurantium (bitter orange)--2004 California Behavioral Risk Factor Surveillance Survey (BRFSS)
AU - Klontz KC
AU - Timbo BB
AU - Street D
Y1 - 2006/10//2006 Oct
N1 - Accession Number: 106019111. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; questions and answers; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9203131.
KW - Citrus -- Adverse Effects
KW - Dietary Supplements -- Adverse Effects
KW - Risk Assessment
KW - Adolescence
KW - Adult
KW - Aged
KW - Appetite -- Drug Effects
KW - California
KW - Cross Sectional Studies
KW - Female
KW - Male
KW - Middle Age
KW - Risk Factors
KW - Socioeconomic Factors
KW - Weight Loss -- Drug Effects
KW - Human
SP - 1747
EP - 1751
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
JA - ANN PHARMACOTHER
VL - 40
IS - 10
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1060-0280
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, USA. karl.klontz@cfsan.fda.gov
U2 - PMID: 16968826.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - NICHOLSON, WILLIAM L.
AU - PADDOCK, CHRISTOPHER D.
AU - DEMMA, LINDA
AU - TRAEGER, MARC
AU - JOHNSON, BRIAN
AU - DICKSON, JEFFREY
AU - McQUISTON, JENNIFER
AU - SWERDLOW, DAVID
T1 - Rocky Mountain Spotted Fever in Arizona: Documentation of Heavy Environmental Infestations of Rhipicephalus sanguineus at an Endemic Site.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/10//
VL - 1078
IS - 1
M3 - Article
SP - 338
EP - 341
SN - 00778923
AB - A recent epidemiologic investigation identified 16 cases and 2 deaths from Rocky Mountain spotted fever (RMSF) in two eastern Arizona communities. Prevalence studies were conducted by collecting free-living ticks (Acari: Ixodidae) from the home sites of RMSF patients and from other home sites within the community. Dry ice traps and flagging confirmed heavy infestations at many of the home sites. Only Rhipicephalus sanguineus ticks were identified and all developmental stages were detected. It is evident that under certain circumstances, this species does transmit Rickettsia rickettsii to humans and deserves reconsideration as a vector in other geographic areas. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACARIDAE
KW - IXODIDAE
KW - RICKETTSIA
KW - RHIPICEPHALUS
KW - ROCKY Mountain spotted fever
KW - TICK-borne diseases
KW - EPIDEMIOLOGY -- Research
KW - ARIZONA
KW - Acari
KW - Ixodidae
KW - Rickettsia rickettsii
KW - RMSF
KW - tick survey
N1 - Accession Number: 22838467; NICHOLSON, WILLIAM L. 1; Email Address: wan6@cdc.gov PADDOCK, CHRISTOPHER D. 2 DEMMA, LINDA 1 TRAEGER, MARC 3 JOHNSON, BRIAN 3 DICKSON, JEFFREY 3 McQUISTON, JENNIFER 1 SWERDLOW, DAVID 1; Affiliation: 1: Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA 2: Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA 3: Indian Health Service, Public Health Service, Whiteriver, Arizona 85941, USA; Source Info: 2006, Vol. 1078 Issue 1, p338; Subject Term: ACARIDAE; Subject Term: IXODIDAE; Subject Term: RICKETTSIA; Subject Term: RHIPICEPHALUS; Subject Term: ROCKY Mountain spotted fever; Subject Term: TICK-borne diseases; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: ARIZONA; Author-Supplied Keyword: Acari; Author-Supplied Keyword: Ixodidae; Author-Supplied Keyword: Rickettsia rickettsii; Author-Supplied Keyword: RMSF; Author-Supplied Keyword: tick survey; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1196/annals.1374.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DEMMA, LINDA J.
AU - EREMEEVA, M.
AU - NICHOLSON, W. L.
AU - TRAEGER, M.
AU - BLAU, D.
AU - PADDOCK, C.
AU - LEVIN, M.
AU - DASCH, G.
AU - CHEEK, J.
AU - SWERDLOW, D.
AU - McQUISTON, J.
T1 - An Outbreak of Rocky Mountain Spotted Fever Associated with a Novel Tick Vector, Rhipicephalus sanguineus, in Arizona, 2004.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/10//
VL - 1078
IS - 1
M3 - Article
SP - 342
EP - 343
SN - 00778923
AB - This study describes preliminary results of an investigation of RMSF in Arizona associated with the brown dog tick, Rhipicephalus sanguineus. High numbers of dogs and heavy infestations of ticks created a situation leading to human disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROCKY Mountain spotted fever
KW - BROWN dog tick
KW - RHIPICEPHALUS
KW - EPIDEMIOLOGY
KW - TICKS as carriers of disease
KW - RICKETTSIAL diseases
KW - COMMUNICABLE diseases -- Transmission
KW - ARIZONA
KW - epidemiology
KW - Rickettsia rickettsii
KW - RMSF
KW - tick
N1 - Accession Number: 22838466; DEMMA, LINDA J. 1 EREMEEVA, M. 1 NICHOLSON, W. L. 1; Email Address: wan6@cdc.gov TRAEGER, M. 1 BLAU, D. 1 PADDOCK, C. 1 LEVIN, M. 1 DASCH, G. 1 CHEEK, J. 1 SWERDLOW, D. 1 McQUISTON, J. 1; Affiliation: 1: Centers for Disease Control and Prevention, Atlanta, Georgia, USA Indian Health Service, Public Health Service, Whiteriver, Arizona, USA; Source Info: 2006, Vol. 1078 Issue 1, p342; Subject Term: ROCKY Mountain spotted fever; Subject Term: BROWN dog tick; Subject Term: RHIPICEPHALUS; Subject Term: EPIDEMIOLOGY; Subject Term: TICKS as carriers of disease; Subject Term: RICKETTSIAL diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: ARIZONA; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: Rickettsia rickettsii; Author-Supplied Keyword: RMSF; Author-Supplied Keyword: tick; Number of Pages: 2p; Document Type: Article
L3 - 10.1196/annals.1374.066
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Budowle, Bruce
AU - Schutzer, Steven E.
AU - Burans, James P.
AU - Beecher, Douglas J.
AU - Cebula, Thomas A.
AU - Chakraborty, Ranajit
AU - Cobb, William T.
AU - Fletcher, Jacqueline
AU - Hale, Martha L.
AU - Harris, Robert B.
AU - Michael A. Heitkamp
AU - Keller, Frederick Paul
AU - Kuske, Cheryl
AU - LeClerc, Joseph E.
AU - Marrone, Babetta L.
AU - McKenna, Thomas S.
AU - Morse, Stephen A.
AU - Rodriguez, Luis L.
AU - Valentine, Nancy B.
AU - Yadev, Jagjit
T1 - Quality Sample Collection, Handling, and Preservation for an Effective Microbial Forensics Program.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/10//
VL - 72
IS - 10
M3 - Article
SP - 6431
EP - 6438
SN - 00992240
AB - The article presents an overview of the October 2005 Department of Homeland Security (DHS) Banbury meeting. The meeting focused on identifying gaps and make recommendations on sample collection, handling, and preservation of microbial forensic evidence. It has been the purpose of the group to inform the greater scientific community of ongoing directions in microbial forensics. Forensic investigation and its procedures are described. The success of a microbial forensic investigation lies in the first phase of crime scene investigation. Therefore, efforts must be intensified in these areas to have a successful job.
KW - FORENSIC sciences
KW - CRIMINAL investigation
KW - CRIME scenes
KW - EVIDENCE
KW - INVESTIGATIONS
KW - COUNTERTERRORISM
KW - NATIONAL security
KW - MICROBIAL contamination
KW - UNITED States. Dept. of Homeland Security
N1 - Accession Number: 22858690; Budowle, Bruce 1 Schutzer, Steven E. 2; Email Address: schutzer@umdnj.edu Burans, James P. 3 Beecher, Douglas J. 1 Cebula, Thomas A. 4 Chakraborty, Ranajit 5 Cobb, William T. 6 Fletcher, Jacqueline 7 Hale, Martha L. 8 Harris, Robert B. 9 Michael A. Heitkamp 10 Keller, Frederick Paul 1 Kuske, Cheryl 11 LeClerc, Joseph E. 4 Marrone, Babetta L. 11 McKenna, Thomas S. 12 Morse, Stephen A. 13 Rodriguez, Luis L. 14 Valentine, Nancy B. 15 Yadev, Jagjit 5; Affiliation: 1: Laboratory Division, Federal Bureau of Investigation, Quantico, Virginia 22135 2: Department of Medicine, University of Medicine and Dentistty of New Jersey-New Jersey Medical School, Newark, New Jersey 071032 3: Department of Homeland Security, Frederick, Maryland 21703 4: Food and Drug Administration, Laurel, Maryland 20708 5: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 6: Cobb Consulting Seivices, Kennewick Washington 993366 7: Department of Entomology & Plant Pathology, Oklahoma State University, Stillwater, Oklahoma 74078 8: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 217028 9: Commonwealth Biotechnologies, Inc., Richmond, Virginia 23235 10: Environmental Biotechnology, Savannah River National Laboratory, Aiken, South Carolina 2980810 11: Los Alamos National Laboratory, Los Alamos, New Mexico 87545 12: Foreign Animal Disease Diagnostic Laboratory (FADDL), USDA JARS Plum Island Animal Disease Center, Greenport, New York 1194412 13: Centers for Disease Control and Prevention, Atlanta, Georgia 30333's 14: Foreign Animal Disease Research Unit, USDA JARS Plum Island Animal Disease Center, Greenport, New York 15: Pacific Northwest National Laboratory, Richland, Washington; Source Info: Oct2006, Vol. 72 Issue 10, p6431; Subject Term: FORENSIC sciences; Subject Term: CRIMINAL investigation; Subject Term: CRIME scenes; Subject Term: EVIDENCE; Subject Term: INVESTIGATIONS; Subject Term: COUNTERTERRORISM; Subject Term: NATIONAL security; Subject Term: MICROBIAL contamination; Company/Entity: UNITED States. Dept. of Homeland Security; NAICS/Industry Codes: 928110 National Security; Number of Pages: 8p; Document Type: Article
L3 - 10.1128/AEM.01165-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nawaz, Mohamed
AU - Kidon Sung
AU - Khan, Saeed A.
AU - Khan, Ashraf A.
AU - Steele, Roger
T1 - Biochemical and Molecular Characterization of Tetracycline-Resistant Aeromonas veronii Isolates from Catfish.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2006/10//
VL - 72
IS - 10
M3 - Article
SP - 6461
EP - 6466
SN - 00992240
AB - Eighty-one tetracycline-resistant Aeromonas sp. strains were isolated from farm-raised catfish. Morphological and biochemical characteristics indicated that 23 of the 81 aeromonads were Aeromonas hydrophila, 7 isolates were Aeromonas trota, 6 isolates were Aeromonas caviae, 42 isolates were Aeromonas veronii, and 3 isolates were Aeromonas jandaei. However, the AluI and MboI restriction fragment length polymorphism (RFLP) patterns of the PCR-amplified 1.4-kb 16S rRNA gene from all 81 tetracycline-resistant aeromonads from catfish were identical to the RFLP banding patterns of A. veronii ATCC 35626, indicating that all 81 isolates were strains of A. veronii. A multiplex PCR assay successfully amplified the 5 tetracycline-resistant genes (tetA to E) from the genomic DNA of all 81 isolates. The assay determined that tetE was the dominant gene occurring in 73/81 (90.0%) of the aeromonads. Plasmids (2.0 to 20 kb) were isolated from 33 of the 81 isolates. Dendrogram analysis of the SpeI pulsed-field gel electrophoresis identified 15 distinct macrorestriction patterns among the isolates. Our results indicate the need for use of 16S rRNA in the identification of Aeromonas spp. and the prevalence of catfish as a reservoir of tet genes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROMONAS
KW - PSEUDOMONADACEAE
KW - BIOCHEMICAL engineering
KW - CATFISH fisheries
KW - TETRACYCLINE
KW - ANTIBACTERIAL agents
KW - MORPHOLOGY
KW - POLYMORPHISM (Zoology)
KW - ANIMAL variation
N1 - Accession Number: 22858693; Nawaz, Mohamed 1; Email Address: mnawaz@nctr.fda.gov Kidon Sung 1 Khan, Saeed A. 1 Khan, Ashraf A. 1 Steele, Roger 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079; Source Info: Oct2006, Vol. 72 Issue 10, p6461; Subject Term: AEROMONAS; Subject Term: PSEUDOMONADACEAE; Subject Term: BIOCHEMICAL engineering; Subject Term: CATFISH fisheries; Subject Term: TETRACYCLINE; Subject Term: ANTIBACTERIAL agents; Subject Term: MORPHOLOGY; Subject Term: POLYMORPHISM (Zoology); Subject Term: ANIMAL variation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1128/AEM.00271-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cutlip, Robert G.
AU - Baker, Brent A.
AU - Geronilla, Kenneth B.
AU - Mercer, Robert R.
AU - Kashon, Michael L.
AU - Miller, Gerald R.
AU - Murlasits, Zsolt
AU - Alway, Stephen E.
T1 - Chronic exposure to stretch–shortening contractions results in skeletal muscle adaptation in young rats and maladaptation in old rats.
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
Y1 - 2006/10//
VL - 31
IS - 5
M3 - Article
SP - 573
EP - 587
PB - Canadian Science Publishing
SN - 17155312
AB - The objective of this research was to investigate skeletal muscle response to a chronic administration of stretch–shortening cycles (SSCs) in young and old rats. Dorsiflexor muscles of old (30 months, n = 5) and young (12 weeks, n = 6) rats were exposed 3 times/week for 4.5 weeks to a protocol of 80 maximal SSCs per exposure in vivo. Skeletal muscle response was characterized by isometric and dynamic performance, as well as by muscle wet mass and quantitative morphological analyses following the exposure period. The performance of the young and old groups was not statistically different at the start of the exposure. By the end of the exposure, however, a statistical difference was noted, as performance increased significantly in the young animals and decreased significantly in the old animals. Muscle wet mass of the left tibialis anterior (TA) in the treated limb was significantly greater in the youngthan in the old animals (p < 0.001), whereas there was no difference in the contra-lateral TA. No degenerative myofibers or changes in non-cellular interstitium were noted in either age group, but a significant increase was observed in the volume of the cellular interstitium in the exposed limb of the old animals (p = 0.01), which is indicative of an inflammatory response. Thus, a chronic exposure of SSCs results in significant performance increase and muscle hypertrophy in young animals, and a significant performance decrease and an increased cellular interstitial response in old animals. These findings suggest that age may impair the ability of skeletal muscle to adapt to repetitive mechanical loading, even in the absence of degeneration. (English) [ABSTRACT FROM AUTHOR]
AB - Le but de cette étude est d’analyser l’effet de l’administration chronique d’une série de cycles d’étirement–raccourcissement (SSCs) sur le muscle squelettique de jeunes et vieux rats. Les muscles dorsifléchisseurs de vieux rats (30 mois, n = 5) et de jeunes rats (12 semaines, n = 6) sont exposés in vivo durant 4,5 semaines à raison de 3 fois par semaine à une série de 80 SSCs maximaux. On évalue la réaction musculaire par des mesures de performance isométrique et dynamique de même que par la masse humide du muscle et l’analyse morphologique quantitative à la suite de la période de stimulation. Au début de la période de stimulation, les performances isométrique et dynamique des deux groupes ne diffèrent pas statistiquement; à la fin de cette période, on observe une amélioration significative de la performance chez les jeunes rats et une diminution significative chez les vieux. La masse humide du jambier antérieur gauche (TA) de la patte expérimentale est significativement plus importante chez les jeunes que chez les vieux (p < 0001); on n’observe aucune différence du côté controlatéral. De plus dans les deux groupes, on n’observe aucune fibre musculaire en dégénérescence ni aucun changement dans l’interstitium non cellulaire; on observe cependant chez les vieux rats une augmentation du volume de l’interstitium cellulaire de la patte expérimentale (p = 0,01) ce qui constitue un indice de réaction inflammatoire. En conséquence, l’exposition chronique à une série de SSCs améliore significativement la performance et favorise l’hypertrophie chez le jeune rat; cette même exposition diminue significativement la performance et augmente la réponse cellulaire interstitielle chez le vieux rat. D’après ces observations, le vieillissement représente une entrave à l’aptitude du muscle à s’adapter à une tâche mécanique répétitive même en l’absence de dégénérescence. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Physiology, Nutrition & Metabolism is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLES
KW - MUSCULOSKELETAL system
KW - HYPERTROPHY
KW - ANIMALS
KW - WOUNDS & injuries
KW - RATS
KW - RESEARCH
KW - cellular interstitium
KW - dorsiflexor muscles
KW - repetitive exposure
KW - stretch—ortening cycles
KW - cycles d'étirement-raccourcissement
KW - exposition répétée
KW - interstitium cellulaire
KW - muscles dorsifléchisseurs
N1 - Accession Number: 23203913; Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov Baker, Brent A. 1 Geronilla, Kenneth B. 1 Mercer, Robert R. 1 Kashon, Michael L. 1 Miller, Gerald R. 1 Murlasits, Zsolt 2 Alway, Stephen E. 2; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, 1095 Don Nehlen Drive, Morgantown, WV 26506, USA 2: Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA; Source Info: Oct2006, Vol. 31 Issue 5, p573; Subject Term: MUSCLES; Subject Term: MUSCULOSKELETAL system; Subject Term: HYPERTROPHY; Subject Term: ANIMALS; Subject Term: WOUNDS & injuries; Subject Term: RATS; Subject Term: RESEARCH; Author-Supplied Keyword: cellular interstitium; Author-Supplied Keyword: dorsiflexor muscles; Author-Supplied Keyword: repetitive exposure; Author-Supplied Keyword: stretch—ortening cycles; Author-Supplied Keyword: cycles d'étirement-raccourcissement; Author-Supplied Keyword: exposition répétée; Author-Supplied Keyword: interstitium cellulaire; Author-Supplied Keyword: muscles dorsifléchisseurs; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Illustrations: 1 Color Photograph, 9 Graphs; Document Type: Article
L3 - 10.1139/H06-033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106244872
T1 - Chronic exposure to stretch-shortening contractions results in skeletal muscle adaptation in young rats and maladaptation in old rats.
AU - Cutlip RG
AU - Baker BA
AU - Geronilla KB
AU - Mercer RR
AU - Kashon ML
AU - Miller GR
AU - Murlasits Z
AU - Alway SE
Y1 - 2006/10//
N1 - Accession Number: 106244872. Language: English. Entry Date: 20070302. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. NLM UID: 101264333.
KW - Adaptation, Physiological
KW - Muscle, Skeletal -- Physiology
KW - Age Factors
KW - Animal Studies
KW - Data Analysis Software
KW - Experimental Studies
KW - Muscle, Skeletal -- Pathology
KW - Post Hoc Analysis
KW - Rats
SP - 573
EP - 587
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
JA - APPL PHYSIOL NUTR METAB
VL - 31
IS - 5
CY - Ottawa, Ontario
PB - Canadian Science Publishing
SN - 1715-5312
AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, 1095 Don Nehlen Drive, Morgantown, WV 26506, USA. rgc8@cdc.gov
U2 - PMID: 17111012.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Aijun Wang
AU - Yuanhui Zhang
AU - Jennifer L. Topmiller
AU - Bennett, James S.
AU - Dunn, Kevin H.
T1 - Tracer Study of Airborne Disease Transmission in an Aircraft Cabin Mock-Up.
JO - ASHRAE Transactions
JF - ASHRAE Transactions
Y1 - 2006/10//
VL - 112
IS - 2
M3 - Article
SP - 697
EP - 705
PB - ASHRAE
SN - 00012505
AB - This paper reports a study on the airborne transmission of the infectious disease(s) in the mock-up of a Boeing 767-300 aircraft cabin, using a tracer gas method with a high temporal resolution. Carbon dioxide was used as the tracer gas to simulate the pulse emitting such as coughing or sneezing of a sick passenger in a commercial aircraft. The net tracer concentration and a self-defined factor called the normalized cumulative factor (CFN) were analyzed. A detailed description of the transient airborne transmission was obtained based on the contour maps of tracer gas propagation from its release source to other locations. The distance between the release source and the receptors, the location of the release source and the total air supply rates were varied, to investigate the dependence of airborne transmission on these factors. The results showed that the close proximity between the occupants increased the exposure risk, and that the location of the release source was an important factor affecting the airborne transmission. In real aircraft, one possible way to decrease the exposure risk of the infectious diseases would be to move the release source from the center to the sides or from the back seats to the front seats. This would facilitate discharging a larger portion of the airborne pollutants directly to the return air duct before they were spread to other locations in the aircraft cabin. Increasing the total air supply rate could also lower the exposure risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of ASHRAE Transactions is the property of ASHRAE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases -- Transmission
KW - AIRBORNE infection
KW - INFECTION
KW - TRACERS (Biology)
KW - CARBON dioxide
KW - BOEING 767 (Jet transport)
KW - AIRCRAFT cabins
KW - AERONAUTICS -- Safety measures
KW - AIR microbiology
KW - SAFETY measures
N1 - Accession Number: 22882562; Aijun Wang Yuanhui Zhang 1 Jennifer L. Topmiller 2 Bennett, James S. 3 Dunn, Kevin H. 4; Affiliation: 1: Professor, Department of Agricultural and Biological Engineering, University of Illinois, Urbana Champaign, Urbana, IL 2: Mechanical Engineer, National Institute for Occupational Safety and Health, Cincinnati, OH 3: Research Engineer, National Institute for Occupational Safety and Health, Cincinnati, OH 4: Research Mechanical Engineer, National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: 2006, Vol. 112 Issue 2, p697; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: AIRBORNE infection; Subject Term: INFECTION; Subject Term: TRACERS (Biology); Subject Term: CARBON dioxide; Subject Term: BOEING 767 (Jet transport); Subject Term: AIRCRAFT cabins; Subject Term: AERONAUTICS -- Safety measures; Subject Term: AIR microbiology; Subject Term: SAFETY measures; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ali, Laila
AU - Khambaty, Farukh
AU - Diachenko, Gregory
T1 - Investigating the suitability of the Calgary Biofilm Device for assessing the antimicrobial efficacy of new agents
JO - Bioresource Technology
JF - Bioresource Technology
Y1 - 2006/10//
VL - 97
IS - 15
M3 - Article
SP - 1887
EP - 1893
SN - 09608524
AB - Abstract: This study investigated the suitability of the Calgary Biofilm Device (CBD), originally designed as a test surrogate for indwelling medical devices, for assessing the efficacy of antimicrobials developed for food and food contact surface disinfection applications. The conditions for the development of uniform biofilms from pure and mixed bacterial cultures of wild type Escherichia coli and Listeria innocua were optimized. We were able to recover ≈2×106 colony forming units (CFU) from the biofilms formed on the individual pegs of the device in 24h. Further, the parameters for the consistent release of the cells from the biofilms were optimized; test showed that the number of cells released was uniform and reproducible. The consistency and reproducibility of the biofilms formed on the pegs was evaluated using scanning electron microscopy and by plate count method. The efficacies of disinfectants on cells residing in biofilms versus planktonic cells were compared. For both species, higher concentrations of disinfectants were needed to eliminate attached cells as compared with planktonic cells. This study establishes the value of the CBD for generating consistent biofilms from either pure or mixed cultures. These biofilms can be used to assess efficacies of disinfectants against cells that have colonized the surfaces of foods and food-processing equipment. Such a system could serve as a standard surrogate for evaluating new disinfectants designed to reduce or eliminate biofilms from food-contact surfaces. [Copyright &y& Elsevier]
AB - Copyright of Bioresource Technology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbial aggregation
KW - Microbial ecology
KW - Biofilms
KW - Escherichia
KW - Calgary Biofilm Device
KW - Disinfectants
KW - Escherichia coli
KW - Listeria innocua
KW - Planktonic cells
N1 - Accession Number: 21338372; Ali, Laila 1; Email Address: Laila.ali@cfsan.fda.gov; Khambaty, Farukh 2; Diachenko, Gregory 1; Affiliations: 1: Division of Chemistry Research and Environmental Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, Room # BE-022, HFS-245, USA; 2: Division of Science Assessment and Technology, Office of Seafood, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Dauphin Island, AL 36528, USA; Issue Info: Oct2006, Vol. 97 Issue 15, p1887; Thesaurus Term: Microbial aggregation; Thesaurus Term: Microbial ecology; Thesaurus Term: Biofilms; Thesaurus Term: Escherichia; Author-Supplied Keyword: Calgary Biofilm Device; Author-Supplied Keyword: Disinfectants; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Listeria innocua; Author-Supplied Keyword: Planktonic cells; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biortech.2005.08.025
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Babu, Uma S.
AU - Gaines, Dennis W.
AU - Lillehoj, Hyun
AU - Raybourne, Richard B.
T1 - Differential reactive oxygen and nitrogen production and clearance of Salmonella serovars by chicken and mouse macrophages
JO - Developmental & Comparative Immunology
JF - Developmental & Comparative Immunology
Y1 - 2006/10//
VL - 30
IS - 10
M3 - Article
SP - 942
EP - 953
SN - 0145305X
AB - Abstract: The objective of the present study was to compare the uptake and killing of Salmonella serovars by murine and avian macrophage cell lines. We used Salmonella enterica serovars Enteritidis (SE338) and Typhimurium (SR11) for this study. Uptake of green fluorescent protein-labeled bacteria was measured using flow cytometry. Cell sorting and plating of viable infected macrophages demonstrated that bacterial clearance was significantly better with J774A.1 compared with HD11 cells. HD11 cells produced significantly higher amounts of nitric oxide (NO) than J774A.1 cells upon infection with SE338 and SR11, whereas J774A.1 cells exhibited greater superoxide production with SR11. Treatment of HD11 cells with recombinant chicken interferon gamma in the absence of bacteria enhanced NO production but did not induce increased levels synergistically with bacteria. Interferon treatment did not influence phagocytosis or increase killing by HD11 cells. [Copyright &y& Elsevier]
AB - Copyright of Developmental & Comparative Immunology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - SALMONELLA
KW - CELLS
KW - MACROPHAGES
KW - Chicken macrophages
KW - Flow cytometry
KW - HD11
KW - J774A.1
KW - Mouse macrophages
KW - Nitric oxide
KW - Salmonella
KW - Superoxide
N1 - Accession Number: 21752076; Babu, Uma S. 1 Gaines, Dennis W. 1 Lillehoj, Hyun 2 Raybourne, Richard B. 1; Email Address: rraybour@cfsan.fda.gov; Affiliation: 1: Immunobiology Branch, Food and Drug Administration, MOD I, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Animal and Parasitic Diseases Laboratory, United States Department of Agriculture, Beltsville, MD 20705, USA; Source Info: Oct2006, Vol. 30 Issue 10, p942; Subject Term: ENTEROBACTERIACEAE; Subject Term: SALMONELLA; Subject Term: CELLS; Subject Term: MACROPHAGES; Author-Supplied Keyword: Chicken macrophages; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: HD11; Author-Supplied Keyword: J774A.1; Author-Supplied Keyword: Mouse macrophages; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: Salmonella; Author-Supplied Keyword: Superoxide; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.dci.2005.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mididoddi, P. K.
AU - Prodduturi, S.
AU - Repka, M. A.
T1 - Influence of Tartaric Acid on the Bioadhesion and Mechanical Properties of Hot-Melt Extruded Hydroxypropyl Cellulose Films for the Human Nail
JO - Drug Development & Industrial Pharmacy
JF - Drug Development & Industrial Pharmacy
Y1 - 2006/10//
VL - 32
IS - 9
M3 - Article
SP - 1059
EP - 1066
PB - Taylor & Francis Ltd
SN - 03639045
AB - The objective of this study was to investigate the influence of tartaric acid (TTA) on the bioadhesive, moisture sorption, and mechanical properties of hot–melt-extruded (HME) hydroxypropyl cellulose (HPC) films containing polymer additives. Two Klucel® EF and LF batches (HPC, MW: 80000 and 95000, respectively) containing the model antifungal drug ketoconazole (one batch of each MW with and without TTA 4%) were prepared into films by HME using a Killion extruder (Model KLB-100). The bioadhesive properties of the HPC films, with and without TTA, were investigated ex vivo on the human nails. The parameters measured were work of adhesion and peak adhesion force (PAF). A statistically significant increase in both the area under the curve (AUC) and PAF was seen for the HME films containing TTA than those without TTA. Moisture content of hot-melt extruded HPC films was determined using thermogravimetric analysis (TGA). TGA data collected at the two-week interval (25°C/60% RH), measured higher moisture content for the TTA-containing films than those without TTA. Tensile strength and percent elongation were determined utilizing a TA.XT2i Texture Analyzer® equipped with a 50-kg load cell, TA-96 grips, and Texture Expert™ software. TTA functioned as an effective plasticizer, increasing percent elongation and decreasing tensile strength of the HPC films. TTA could potentially be a candidate for transnail applications in film devices prepared by hot-melt extrusion technology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Development & Industrial Pharmacy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXTRUSION process
KW - TARTARIC acid
KW - BIOADHESIVE drug delivery systems
KW - KETOCONAZOLE
KW - ANTIFUNGAL agents
KW - GLUCANS
KW - Bioadhesion
KW - Hot-melt extrusion
KW - Mechanical properties
KW - Nail
KW - Tartaric acid
KW - Thermogravimetric analysis (TGA)
N1 - Accession Number: 22530541; Mididoddi, P. K. 1; Prodduturi, S. 2; Repka, M. A. 3; Affiliations: 1: Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi, USA; 2: Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, Missouri, USA; 3: The National Center for Natural Products Research, The University of Mississippi, University, Mississippi, USA; Issue Info: Oct2006, Vol. 32 Issue 9, p1059; Thesaurus Term: EXTRUSION process; Subject Term: TARTARIC acid; Subject Term: BIOADHESIVE drug delivery systems; Subject Term: KETOCONAZOLE; Subject Term: ANTIFUNGAL agents; Subject Term: GLUCANS; Author-Supplied Keyword: Bioadhesion; Author-Supplied Keyword: Hot-melt extrusion; Author-Supplied Keyword: Mechanical properties; Author-Supplied Keyword: Nail; Author-Supplied Keyword: Tartaric acid; Author-Supplied Keyword: Thermogravimetric analysis (TGA); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1080/03639040600683410
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Landsberg, Jan H.
AU - Hall, Sherwood
AU - Johannessen, Jan N.
AU - White, Kevin D.
AU - Conrad, Stephen M.
AU - Abbott, Jay P.
AU - Flewelling, Leanne J.
AU - Richardson, R. William
AU - Dickey, Robert W.
AU - Jester, Edward L. E.
AU - Etheridge, Stacey M.
AU - Deeds, Jonathan R.
AU - Van Dolah, Frances M.
AU - Leighfield, Tod A.
AU - Yinglin Zou
AU - Beaudry, Clarke G.
AU - Benner, Ronald A.
AU - Rogers, Patricia L.
AU - Scott, Paula S.
AU - Kawabata, Kenji
T1 - Saxitoxin Puffer Fish Poisoning in the United States, with the First Report of Pyrodinium bahamenseas the Putative Toxin Source.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/10//
VL - 114
IS - 10
M3 - Article
SP - 1502
EP - 1507
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: From January 2002 to May 2004, 28 puffer fish poisoning (PFP) cases in Florida, New Jersey, Virginia, and New York were linked to the Indian River Lagoon (IRL) in Florida. Saxitoxins (STXs) of unknown source were first identified in fillet remnants from a New Jersey PFP case in 2002. METHODS: We used the standard mouse bioassay (MBA), receptor binding assay (RBA), mouse neuroblastoma cytotoxicity assay (MNCA), Ridascreen ELISA, MIST Alert assay, HPLC, and liquid chromatography-mass spectrometry (LC-MS) to determine the presence of STX, decarbamoyl STX (dc-STX), and N-sulfocarbamoyl (B1) toxin in puffer fish tissues, clonal cultures, and natural bloom samples of Pyrodinium bahamense from the IRL. RESULTS: We found STXs in 516 IRL southern (Sphoeroides nephelus), checkered (Sphoeroides testudineus), and bandtail (Sphoeroides spengleri) puffer fish. During 36 months of monitoring, we detected STXs in skin, muscle, and viscera, with concentrations up to 22,104 μg STX equivalents (eq)/100 g tissue (action level, 80 μg STX eq/100 g tissue) in ovaries. Puffer fish tissues, clonal cultures, and natural bloom samples of P. bahamense from the IRL tested toxic in the MBA, RBA, MNCA, Ridascreen ELISA, and MIST Alert assay and positive for STX, dc-STX, and B1 toxin by HPLC and LC-MS. Skin mucus of IRL southern puffer fish captive for 1-year was highly toxic compared to Florida Gulf coast puffer fish. Therefore, we confirm puffer fish to be a hazardous reservoir of STXs in Florida's marine waters and implicate the dinoflagellate P. bahamense as the putative toxin source. CONCLUSIONS: Associated with fatal paralytic shellfish poisoning (PSP) in the Pacific but not known to be toxic in the western Atlantic, P. bahamense is an emerging public health threat. We propose characterizing this food poisoning syndrome as saxitoxin puffer fish poisoning (SPFP) to distinguish it from PFP, which is traditionally associated with tetrodotoxin, and from PSP caused by STXs in shellfish. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Seafood poisoning
KW - Seafood -- Contamination
KW - Saxitoxin
KW - Marine toxins
KW - Effect of chemicals on fishes
KW - Red tide
KW - Puffers (Fish)
KW - Health risk assessment
KW - Poisonous fishes
KW - United States
KW - dinoflagellate
KW - Florida
KW - harmful algae
KW - puffer fish
KW - Pyrodinium bahamense
KW - saxitoxin puffer fish poisoning
KW - saxitoxins
N1 - Accession Number: 22882751; Landsberg, Jan H. 1; Email Address: jan.landsberg@myfwc.com; Hall, Sherwood 2; Johannessen, Jan N. 3; White, Kevin D. 4; Conrad, Stephen M. 2; Abbott, Jay P. 1; Flewelling, Leanne J. 1; Richardson, R. William 1; Dickey, Robert W. 5; Jester, Edward L. E. 5; Etheridge, Stacey M. 2; Deeds, Jonathan R. 2; Van Dolah, Frances M. 6; Leighfield, Tod A. 6; Yinglin Zou 7; Beaudry, Clarke G. 4; Benner, Ronald A. 2; Rogers, Patricia L. 2; Scott, Paula S. 1; Kawabata, Kenji 1; Affiliations: 1: Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, St. Petersburg, Florida, USA; 2: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, Maryland, USA; 3: Food and Drug Administration, Office of the Commissioner, Rockville, Maryland, USA; 4: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA; 5: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA; 6: National Oceanic and Atmospheric Administration, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina, USA; 7: Key Laboratory of Science and Engineering for Marine Ecology and Environment, First Institute of Oceanography, State Oceanic Administration, Qingdao, China; Issue Info: Oct2006, Vol. 114 Issue 10, p1502; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Seafood poisoning; Thesaurus Term: Seafood -- Contamination; Thesaurus Term: Saxitoxin; Thesaurus Term: Marine toxins; Thesaurus Term: Effect of chemicals on fishes; Thesaurus Term: Red tide; Thesaurus Term: Puffers (Fish); Thesaurus Term: Health risk assessment; Subject Term: Poisonous fishes; Subject: United States; Author-Supplied Keyword: dinoflagellate; Author-Supplied Keyword: Florida; Author-Supplied Keyword: harmful algae; Author-Supplied Keyword: puffer fish; Author-Supplied Keyword: Pyrodinium bahamense; Author-Supplied Keyword: saxitoxin puffer fish poisoning; Author-Supplied Keyword: saxitoxins; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.8998
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Prince, Mary M.
AU - Ruder, Avima M.
AU - Hein, Misty J.
AU - Waters, Martha A.
AU - Whelan, Elizabeth A.
AU - Nilsen, Nancy
AU - Ward, Elizabeth M.
AU - Schnorr, Teresa M.
AU - Laber, Patricia A.
AU - Davis-King, Karen E.
T1 - Mortality and Exposure Response among 14,458 Electrical Capacitor Manufacturing Workers Exposed to Polychlorinated Biphenyls (PCBs).
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/10//
VL - 114
IS - 10
M3 - Article
SP - 1508
EP - 1514
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: We expanded an existing cohort of workers (n = 2,588) considered highly exposed to polychlorinated biphenyls (PCBs) at two capacitor manufacturing plants to include all workers with at least 90 days of potential PCB exposure during 1939–1977 (n = 14,458). Causes of death of a priori interest included liver and rectal cancers, previously reported for the original cohort, and non-Hodgkin lymphoma (NHL), melanoma, and breast, brain, intestine, stomach, and prostate cancers, based on other studies. METHODS: We ascertained vital status of the workers through 1998, and cumulative PCB exposure was estimated using a new job exposure matrix. Analyses employed standardized mortality ratios (SMRs; U.S., state, and county referents) and Poisson regression modeling. RESULTS: Mortality from NHL, melanoma, and rectal, breast, and brain cancers were neither in excess nor associated with cumulative exposure. Mortality was not elevated for liver cancer [21 deaths; SMR 0.89; 95% confidence interval (CI), 0.55-1.36], but increased with cumulative exposure (trend p-value = 0.071). Among men, stomach cancer mortality was elevated (24 deaths; SMR 1.53; 95% CI, 0.98-2.28) and increased with cumulative exposure (trend p-value = 0.039). Among women, intestinal cancer mortality was elevated (67 deaths; SMR 1.31; 95% CI, 1.02–1.66), especially in higher cumulative exposure categories, but without a clear trend. Prostate cancer mortality, which was not elevated (34 deaths; SMR 1.04; 95% CI, 0.72–1.45), increased with cumulative exposure (trend p-value = 0.0001). CONCLUSIONS: This study corroborates previous studies showing increased liver cancer mortality, but we cannot clearly associate rectal, stomach, and intestinal cancers with PCB exposure. This is the first PCB cohort showing a strong exposure-response relationship for prostate cancer mortality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial toxicology
KW - Occupational diseases
KW - Polychlorinated biphenyls
KW - Health risk assessment
KW - Occupational mortality
KW - Cancer -- Etiology
KW - Workplace exposure to hazardous substances
KW - Health status indicators
KW - Capacitor industry
KW - cancer
KW - electrical capacitor manufacturing
KW - liver cancer
KW - mortality
KW - occupational exposure
KW - PCBs
KW - polychlorinated biphenyls
KW - prostate cancer
N1 - Accession Number: 22882752; Prince, Mary M. 1; Ruder, Avima M. 1; Email Address: amr2@cdc.gov; Hein, Misty J. 1; Waters, Martha A. 1; Whelan, Elizabeth A. 1; Nilsen, Nancy 1; Ward, Elizabeth M. 1; Schnorr, Teresa M. 1; Laber, Patricia A. 1; Davis-King, Karen E. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Cincinnati, Ohio, USA; Issue Info: Oct2006, Vol. 114 Issue 10, p1508; Thesaurus Term: Industrial toxicology; Thesaurus Term: Occupational diseases; Thesaurus Term: Polychlorinated biphenyls; Thesaurus Term: Health risk assessment; Subject Term: Occupational mortality; Subject Term: Cancer -- Etiology; Subject Term: Workplace exposure to hazardous substances; Subject Term: Health status indicators; Subject Term: Capacitor industry; Author-Supplied Keyword: cancer; Author-Supplied Keyword: electrical capacitor manufacturing; Author-Supplied Keyword: liver cancer; Author-Supplied Keyword: mortality; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: PCBs; Author-Supplied Keyword: polychlorinated biphenyls; Author-Supplied Keyword: prostate cancer; NAICS/Industry Codes: 334416 Capacitor, Resistor, Coil, Transformer, and Other Inductor Manufacturing; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423690 Other Electronic Parts and Equipment Merchant Wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1289/ehp.9175
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - PERCEIVED DISCRIMINATION IN HEALTH CARE AMONG AMERICAN INDIANS/ALASKA NATIVES.
AU - Johansson, Patrik
AU - Jacobsen, Clemma
AU - Buchwald, Dedra
JO - Ethnicity & Disease
JF - Ethnicity & Disease
Y1 - 2006/10//
VL - 16
IS - 4
SP - 766
EP - 771
SN - 1049510X
N1 - Accession Number: 23492360; Author: Johansson, Patrik: 1,2,3 email: pjohansson@dc.doctorscommunity.corn. Author: Jacobsen, Clemma: 3,4 Author: Buchwald, Dedra: 3,4 ; Author Affiliation: 1 Agency for Healthcare Research and Quality, Rockville, Maryland: 2 Harvard Medical School, Cambridge, Massachusetts: 3 The American Indian and Alaska Native Programs, University of Colorado Health Sciences Center, Denver, Colorado: 4 Department of Medicine, University of Washington, Seattle, Washington; No. of Pages: 6; Language: English; Publication Type: Article; Update Code: 20160329
N2 - The article examines perceived discrimination in health care among American Indians in Alaska. The prevalence of alleged health care discrimination among Alaska Natives is compared with those of African Americans, Asian Americans and Whites. The reasons for the perceived discrimination are also discussed.
KW - *MEDICAL care
KW - DISCRIMINATION in medical care
KW - NATIVE Americans
KW - ETHNIC groups
KW - DISCRIMINATION
KW - ALASKA
KW - Alaska Native
KW - American Indian
KW - Health Disparities
KW - Perceived Discrimination
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Sahu, Saura C.
AU - Ruggles, Dennis I.
AU - O’Donnell, Michael W.
T1 - Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2006/10//
VL - 44
IS - 10
M3 - Article
SP - 1751
EP - 1757
SN - 02786915
AB - Abstract: Nordihydroguaiaretic acid (NDGA) is a polyphenol. It is present at high concentrations in the leaves of the evergreen desert shrub, Larrea tridentate (Creosote bush), which has a long history of medicinal use traditionally by the native Americans and Mexicans. It is generally believed that the antioxidant properties of NDGA are responsible for the medicinal value of this desert shrub. The clone-9 rat hepatocyte cultures were used as an in vitro model to assess the hepatotoxic potential of NDGA and to determine whether it exhibits any prooxidant activity. The hepatocyte cultures were treated with NDGA for 2h at 37°C at concentrations of 0–100μM. After the treatment period the cells, the culture supernatants and cell lysates were assayed for evaluation of prooxidant activity and toxicity of NDGA. Oxidative stress level and oxidative cell injury as measured by the peroxidation of membrane lipids and DNA double-strand breaks were used to index prooxidant activity. Cytotoxicity as measured by the leakage of the liver enzyme lactate dehydrogenase (LDH) into the culture medium, mitochondrial function and extent of cell proliferation were used as the endpoints of toxicity. Significant concentration-dependent differences were observed in these biomarkers over the concentration range examined demonstrating the prooxidant activity and toxicity of NDGA in clone-9 rat hepatocyte cultures. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYPHENOLS
KW - LARREA
KW - SHRUBS
KW - ANTIOXIDANTS
KW - CREOSOTE bush
KW - LIVER cells
KW - Clone-9 cells
KW - Hepatocytes
KW - Hepatotoxicity
KW - Liver toxicity
KW - NDGA
N1 - Accession Number: 22013207; Sahu, Saura C. 1; Email Address: saura.sahu@fda.hhs.gov Ruggles, Dennis I. 2 O’Donnell, Michael W. 2; Affiliation: 1: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Division of Mathematics, Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Oct2006, Vol. 44 Issue 10, p1751; Subject Term: POLYPHENOLS; Subject Term: LARREA; Subject Term: SHRUBS; Subject Term: ANTIOXIDANTS; Subject Term: CREOSOTE bush; Subject Term: LIVER cells; Author-Supplied Keyword: Clone-9 cells; Author-Supplied Keyword: Hepatocytes; Author-Supplied Keyword: Hepatotoxicity; Author-Supplied Keyword: Liver toxicity; Author-Supplied Keyword: NDGA; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fct.2006.05.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tournas, V.H.
AU - Heeres, J.
AU - Burgess, L.
T1 - Moulds and yeasts in fruit salads and fruit juices
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/10//
VL - 23
IS - 7
M3 - Article
SP - 684
EP - 688
SN - 07400020
AB - Abstract: Thirty-eight fruit salad samples including cantaloupe, citrus fruits, honeydew, pineapple, cut strawberries and mixed fruit salads, and 65 pasteurized fruit juice samples (apple, carrot, grapefruit, grape and orange juices, apple cider, and soy milk) were purchased from local supermarkets in the Washington, DC area and tested for fungal contamination. The majority of fruit salad samples (97%) were contaminated with yeasts at levels ranging from <2.0 to 9.72log10 of colony forming units per gram (cfu/g). Frequently encountered yeasts were Pichia spp., Candida pulcherrima, C. lambica, C. sake, Rhodotorula spp., and Debaryomyces polymorphus. Low numbers of Penicillium spp. were found in pineapple salads, whereas Cladosporium spp. were present in mixed fruit and cut strawberry salads. Twenty-two per cent of the fruit juice samples tested showed fungal contamination. Yeasts were the predominant contaminants ranging from <1.0 to 6.83log10 cfu/ml. Yeasts commonly found in fruit juices were C. lambica, C. sake, and Rhodotorula rubra. Geotrichum spp. and low numbers of Penicillium and Fusarium spp. (1.70 and 1.60log10 cfu/ml, respectively) were present in grapefruit juice. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YEAST
KW - FRUIT salads
KW - FRUIT juices
KW - WASHINGTON (D.C.)
KW - Fruit juices
KW - Fruit salads
KW - Moulds
KW - Yeasts
N1 - Accession Number: 20575117; Tournas, V.H. 1; Email Address: vtournas@cfsan.fda.gov Heeres, J. 2 Burgess, L. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition (HFS-315), Food and Drug Administration, College Park, MD 20740, USA 2: JIFSAN/University of Maryland, College Park, MD 20740, USA; Source Info: Oct2006, Vol. 23 Issue 7, p684; Subject Term: YEAST; Subject Term: FRUIT salads; Subject Term: FRUIT juices; Subject Term: WASHINGTON (D.C.); Author-Supplied Keyword: Fruit juices; Author-Supplied Keyword: Fruit salads; Author-Supplied Keyword: Moulds; Author-Supplied Keyword: Yeasts; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311421 Fruit and Vegetable Canning; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.fm.2006.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jackson, L.S.
T1 - Book review: Toxins in Food
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2006/10//
VL - 23
IS - 7
M3 - Book Review
SP - 708
EP - 708
SN - 07400020
N1 - Accession Number: 20575121; Jackson, L.S. 1; Email Address: Lauren.Jackson@cfsan.fda.gov; Affiliation: 1: Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Rd., Summit-Argo, IL 60501, USA; Source Info: Oct2006, Vol. 23 Issue 7, p708; Number of Pages: 1p; Document Type: Book Review
L3 - 10.1016/j.fm.2005.11.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Hin C.
AU - Goodman, Jesse L.
T1 - Anaplasma phagocytophilum causes global induction of antiapoptosis in human neutrophils
JO - Genomics
JF - Genomics
Y1 - 2006/10//
VL - 88
IS - 4
M3 - Article
SP - 496
EP - 503
SN - 08887543
AB - Abstract: Anaplasma phagocytophilum (Ap), the agent of the tick-borne disease human granulocytic anaplasmosis, is an obligate intracellular pathogen unique in its ability to target and replicate within neutrophils. It profoundly inhibits neutrophil apoptosis, prolonging neutrophil survival from hours to days. To determine the basis of antiapoptosis, we compared gene expression in Ap-infected vs mock-infected human neutrophils. Antiapoptosis genes were consistently and significantly up-regulated (2- to 15-fold) within 1–3 h. These genes synergistically inhibit apoptosis through several interconnected pathways, including p38MAPK (MAP2K3), ERK (IER3), PI3K (PRKCD), and NF-κB (BCL2A1, NFKB1, NFKBIA, GADD45B). Both extrinsic death receptor (TNFAIP3, CFLAR, SOD2) and intrinsic mitochondrial (BCL2A1, PIM2, BIRC3) pathways were affected as confirmed by reductions in both caspase 3 and caspase 8 activities. Several important antiapoptotic genes noted to be up-regulated in Ap-infected neutrophils were not up-regulated during Ap infection of HL-60 cells (which is not antiapoptotic). In conclusion, just as apoptosis may be triggered through multiple molecular pathways, effective antiapoptosis of neutrophils is achieved rapidly and redundantly by this intracellular pathogen dependent on cell survival. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TICK-borne diseases
KW - ANAPLASMOSIS
KW - INTRACELLULAR pathogens
KW - NEUTROPHILS
KW - Anaplasma phagocytophilum
KW - Antiapoptosis
KW - Ehrlichiosis
KW - Human granulocytic anaplasmosis
KW - Microarray analysis
KW - Neutrophils
N1 - Accession Number: 22592774; Lee, Hin C. 1 Goodman, Jesse L. 2; Email Address: jesse.goodman@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Office of the Center Director, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Campus, 8800 Rockville Pike, Building 29B, Suite 5NN01, HFM-1, Bethesda, MD 20892, USA; Source Info: Oct2006, Vol. 88 Issue 4, p496; Subject Term: TICK-borne diseases; Subject Term: ANAPLASMOSIS; Subject Term: INTRACELLULAR pathogens; Subject Term: NEUTROPHILS; Author-Supplied Keyword: Anaplasma phagocytophilum; Author-Supplied Keyword: Antiapoptosis; Author-Supplied Keyword: Ehrlichiosis; Author-Supplied Keyword: Human granulocytic anaplasmosis; Author-Supplied Keyword: Microarray analysis; Author-Supplied Keyword: Neutrophils; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ygeno.2006.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blanciforti, Laura A.
AU - Luster, Michael I.
T1 - Considerations in Estimating Social and Economic Impacts of Immunotoxic Agents.
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2006/10//
VL - 12
IS - 5
M3 - Article
SP - 888
EP - 903
SN - 10807039
AB - To make appropriate regulatory policy decisions, the potential social and economic impacts of the policy must first be established. For environmental and occupational agents, social and economic impacts are derived from animal toxicology and, when available, human studies that serve as the base for risk-benefit analysis (RBA). Because immune function is associated with resistance to infectious disease, developing RBA for data derived from immunotoxicology studies will require determining the changes in the frequency or severity of infectious disease resulting from an exposure. Fortunately, considerable information is readily available for identifying the frequency of infectious diseases in the general population and its social and economic impacts and to assist the risk assessor when conducting RBA for immunotoxicology endpoints. The following is a brief review describing some issues in using immunotoxicity data when conducting RBA. It presents an economic methodology to determine the economic impacts of infectious diseases to society, sources where these types of information are available, and an example using a specific infectious disease, otitis media. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Ecological Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOTOXICOLOGY
KW - ECONOMIC impact
KW - SOCIAL impact assessment
KW - COMMUNICABLE diseases
KW - NATURAL immunity
KW - OTITIS media
KW - TOXICOLOGY
KW - RISK assessment
KW - PUBLIC health
KW - cost of illness
KW - economic impact
KW - immune system disorders
KW - immunotoxicology
KW - risk assessment
KW - risk factors
N1 - Accession Number: 22255130; Blanciforti, Laura A. 1; Email Address: LBlanciforti@cdc.gov Luster, Michael I. 2; Affiliation: 1: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 2: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Source Info: Oct2006, Vol. 12 Issue 5, p888; Subject Term: IMMUNOTOXICOLOGY; Subject Term: ECONOMIC impact; Subject Term: SOCIAL impact assessment; Subject Term: COMMUNICABLE diseases; Subject Term: NATURAL immunity; Subject Term: OTITIS media; Subject Term: TOXICOLOGY; Subject Term: RISK assessment; Subject Term: PUBLIC health; Author-Supplied Keyword: cost of illness; Author-Supplied Keyword: economic impact; Author-Supplied Keyword: immune system disorders; Author-Supplied Keyword: immunotoxicology; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: risk factors; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 16p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1080/10807030600826953
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jin-Kyu Choi
AU - Seok-Ju Park
AU - Yong-Chul Jun
AU - Jae-Min Oh
AU - Byung-Hoon Jeong
AU - Hyun-Pil Lee
AU - Sue-Nie Park
AU - Carp, Richard I.
AU - Yong-Sun Kim
T1 - Generation of Monoclonal Antibody Recognized by the GXXXG Motif (Glycine Zipper) of Prion Protein.
JO - Hybridoma: A Journal of Molecular Immunology & Experimental & Clinical Immunotherapy
JF - Hybridoma: A Journal of Molecular Immunology & Experimental & Clinical Immunotherapy
Y1 - 2006/10//
VL - 25
IS - 5
M3 - Article
SP - 271
EP - 277
SN - 15540014
AB - To develop monoclonal antibodies (MAbs) to react with normal prion protein (PrPC) and abnormal isoform of prion protein (PrPSc), PrPSc was isolated from brains of 263K scrapie-infected hamsters and immunized to PrP knockout mice. We developed two hybridomas, 3F10 and 1C5 (IgG1), of which epitope mappings were screened by using glutathione S-transferase (GST) fusion proteins of recombinant hamster prion protein and suitable peptides. 3F10 showed a high affinity for hamster and mouse PrP and was demonstrated to recognize the residues 137-151. 1C5 recognizes the region 119-130 corresponding to the GXXXG motif, the glycine zipper region, conserved in all mammals. In the immunohistochemical analysis, the positive staining for PrPSc was observed in the extracellular compartment of scrapie-infected brains but not in the normal brains. However, in Western blot, these antibodies recognized both normal and abnormal prion proteins. These results suggested that the developed mouse MAbs are specific to prion protein and can recognize abnormal prion protein more effectively than normal prion protein in immunohistochemistry. Therefore, these antibodies could be utilized as a useful reagent for the analysis of biochemical, structural, and functional properties between PrPC and PrPSc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hybridoma: A Journal of Molecular Immunology & Experimental & Clinical Immunotherapy is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - PRIONS
KW - PROTEINS
KW - IMMUNIZATION
KW - IMMUNOHISTOCHEMISTRY
N1 - Accession Number: 23193417; Jin-Kyu Choi 1 Seok-Ju Park 1 Yong-Chul Jun 1 Jae-Min Oh 1 Byung-Hoon Jeong 1 Hyun-Pil Lee 1 Sue-Nie Park 2 Carp, Richard I. 3 Yong-Sun Kim 1,4; Email Address: yskim@hallym.ac.kr; Affiliation: 1: Ilsong Institute of Life Science, College of Medicine, Hallym University, Kyeonggi-Do, Republic of Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea 3: New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 4: Department of Microbiology, College of Medicine, Hallym University, Kyeonggi-Do, Republic of Korea; Source Info: Oct2006, Vol. 25 Issue 5, p271; Subject Term: MONOCLONAL antibodies; Subject Term: PRIONS; Subject Term: PROTEINS; Subject Term: IMMUNIZATION; Subject Term: IMMUNOHISTOCHEMISTRY; Number of Pages: 7p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Iwasaki, Kenji
AU - Swanson, Naomi G.
AU - Sauter, Steven L.
T1 - The First NIIH — NIOSH Symposium on Long Working Hours: Summary.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Proceeding
SP - 529
EP - 530
SN - 00198366
AB - Information about industrial health discussed during the Japanese National Institute of Industrial Health and National Institute for Occupational Safety and Health symposium that was held on March 22, 2006 in the U.S. is presented. The symposium aims to summarize the trends of long working hours in Japan and the U.S., as well as the effects on health, safety and economy. Doctor Kenji Iwasaki presented Karoshi problems, while Doctor Ted Schard discussed safety issues in fatigued workers.
KW - Industrial hygiene
KW - Conferences & conventions
KW - Industrial safety -- Congresses
KW - Labor time
KW - United States
KW - National Institute for Occupational Safety & Health
KW - Iwasaki, Kenji
KW - Schard, Ted
N1 - Accession Number: 25253758; Nakata, Akinori 1,2; Takahashi, Masaya 1; Iwasaki, Kenji 1; Swanson, Naomi G. 2; Sauter, Steven L. 2; Affiliations: 1: National Institute of Occupational Safety and Health, Japan; 2: Organizational Science and Human Factors Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, USA; Issue Info: 2006, Vol. 44 Issue 4, p529; Thesaurus Term: Industrial hygiene; Subject Term: Conferences & conventions; Subject Term: Industrial safety -- Congresses; Subject Term: Labor time; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; People: Iwasaki, Kenji; People: Schard, Ted; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Proceeding
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Caruso, Claire C.
T1 - Possible Broad Impacts of Long Work Hours.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 531
EP - 536
SN - 00198366
AB - The article presents the research about the relation of long work hours to a wide range of risks to workers, families, employers and community in the U.S. According to the author, the risks are speculated to stem from less time to recover from work and less time to attend to non-work responsibilities. Several risks to workers include sleep deprivation and poor recovery from work, while risks to families include delayed marriages. Details of the risks to employers and community are presented.
KW - Industrial safety
KW - Occupational hazards
KW - Working hours
KW - Labor time
KW - Job stress
KW - Marital conflict
KW - United States
KW - Occupational diseases
KW - Occupational exposure
KW - Occupational injuries
KW - Sleep
KW - Work hours
KW - Work schedule
KW - Work schedule tolerance
N1 - Accession Number: 25253759; Caruso, Claire C. 1; Affiliations: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226-1998, USA; Issue Info: 2006, Vol. 44 Issue 4, p531; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational hazards; Subject Term: Working hours; Subject Term: Labor time; Subject Term: Job stress; Subject Term: Marital conflict; Subject: United States; Author-Supplied Keyword: Occupational diseases; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: Occupational injuries; Author-Supplied Keyword: Sleep; Author-Supplied Keyword: Work hours; Author-Supplied Keyword: Work schedule; Author-Supplied Keyword: Work schedule tolerance; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Iwasaki, Kenji
AU - Takahashi, Masaya
AU - Nakata, Akinori
T1 - Health Problems due to Long Working Hours in Japan: Working Hours, Workers' Compensation (Karoshi), and Preventive Measures.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 537
EP - 540
SN - 00198366
AB - The article discusses the health problems of Japanese workers due to long working hours in Japan, and assesses the preventive measures that the government has implemented. According to the Ministry of Health, Labor and Welfare, there are about three hundred cases of brain and heart diseases that are recognized as a result from overwork. The agency has been working to establish more appropriate compensation system for overwork. Details regarding the overwork standards are cited.
KW - Industrial hygiene
KW - Working hours
KW - Employee health promotion
KW - Workers' compensation
KW - Japan
KW - Health measures
KW - Karoshi
KW - Long working hours
KW - Working time law
KW - Japan. Kosei Rodosho
N1 - Accession Number: 25253760; Iwasaki, Kenji 1; Takahashi, Masaya 1; Nakata, Akinori 1,2; Affiliations: 1: Institute of Industrial Health, National Institute of Occupational Safety and Health, Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan; 2: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Issue Info: 2006, Vol. 44 Issue 4, p537; Thesaurus Term: Industrial hygiene; Subject Term: Working hours; Subject Term: Employee health promotion; Subject Term: Workers' compensation; Subject: Japan; Author-Supplied Keyword: Health measures; Author-Supplied Keyword: Karoshi; Author-Supplied Keyword: Long working hours; Author-Supplied Keyword: Working time law ; Company/Entity: Japan. Kosei Rodosho; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nakata, Akinori
AU - Araki, Shunichi
AU - Sang-Hwoi Park
AU - Jong-Tae Park
AU - Dae-Sung Kim
AU - Hee-Chan Park
AU - Yokoyama, Kazuhito
T1 - Decreases in CD8+ T, Naive (CD4+CD45RA+) T, and B (CD19+) Lymphocytes by Exposure to Manganese Fume.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 592
EP - 597
SN - 00198366
AB - The article presents the study which examines the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men in Japan. The B (CD19+) lymphocytes, serum immunoglobulins together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders exposed to Mn fume. Results show that T lymphocytes particularly CD8+, CD4+CD45RA+ T lymphocytes and CD19+ B lymphocytes are affected by exposure to Mn fume.
KW - Manganese
KW - Threshold limit values (Industrial toxicology)
KW - Welders (Persons)
KW - Immunotoxicology
KW - T cells
KW - Lymphocytes
KW - Japan
KW - CD19+ B lymphocyte
KW - CD8+ T lymphocyte
KW - Immunotoxicity
KW - Lymphocyte subpopulation
KW - Naive (CD4+CD45RA+) T lymphocyte
KW - Occupational exposure
KW - Welders
N1 - Accession Number: 25253766; Nakata, Akinori 1,2; Araki, Shunichi 1,3; Sang-Hwoi Park 4; Jong-Tae Park 5; Dae-Sung Kim 5; Hee-Chan Park 6; Yokoyama, Kazuhito 7; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Research Participation Program of the Oak Ridge Institute for Science and Education, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; 3: Professor Emeritus, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 4: Division of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3 Konodai, Ichikawa, Chiba 272-0827, Japan; 5: Department of Social Medicine, College of Medicine, University of Hallym, 94-200, Youngdungpo-ku, Seoul 150-030, Korea; 6: Department of Preventive Medicine, College of Medicine, Korea University, 126-1, 5-Ka, Anam-dong, Sungbukku, Seoul 136-705, Korea; 7: Department of Public Health and Preventive Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan; Issue Info: 2006, Vol. 44 Issue 4, p592; Thesaurus Term: Manganese; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Welders (Persons); Subject Term: Immunotoxicology; Subject Term: T cells; Subject Term: Lymphocytes; Subject: Japan; Author-Supplied Keyword: CD19+ B lymphocyte; Author-Supplied Keyword: CD8+ T lymphocyte; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Lymphocyte subpopulation; Author-Supplied Keyword: Naive (CD4+CD45RA+) T lymphocyte; Author-Supplied Keyword: Occupational exposure; Author-Supplied Keyword: Welders; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kobayashi, Kenichi
AU - Miyagawa, Muneyuki
AU - Rui-Sheng Wang
AU - Suda, Megumi
AU - Sekiguchi, Soichiro
AU - Honmia, Takeshi
T1 - Effects of in Utero and Lactational Exposure to Di(2-ethylhexyl)phthalate on Somatic and Physical Development in Rat Offspring.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 652
EP - 660
SN - 00198366
AB - The article presents the study which examines whether in utero and lactational exposure to Di(2-ethylhexyl)phythalate (DEHP) affects postnatal somatic growth of rat offspring in Japan. Pregnant rats were orally administered with various doses of DEHP from gestational day. The findings revealed that in utero and lactational exposure to various concentrations of DEHP has little effect on postnatal development.
KW - Diethylhexyl phthalate
KW - Plasticizers
KW - Animal young
KW - Lactation -- Regulation
KW - Rats
KW - Japan
KW - Di(2-ethylhexyl)phthalate
KW - In utero and lactational exposure
KW - Offspring
KW - Postnatal development
KW - Rat
N1 - Accession Number: 25253774; Kobayashi, Kenichi 1; Miyagawa, Muneyuki 1; Rui-Sheng Wang 1; Suda, Megumi 1; Sekiguchi, Soichiro 1; Honmia, Takeshi; Affiliations: 1: National Institute of Occupational Safety and Health, 21-1, Nagao 6-chome, Tama-Ku, Kawasaki 214-8585, Japan; Issue Info: 2006, Vol. 44 Issue 4, p652; Thesaurus Term: Diethylhexyl phthalate; Thesaurus Term: Plasticizers; Thesaurus Term: Animal young; Subject Term: Lactation -- Regulation; Subject Term: Rats; Subject: Japan; Author-Supplied Keyword: Di(2-ethylhexyl)phthalate; Author-Supplied Keyword: In utero and lactational exposure; Author-Supplied Keyword: Offspring; Author-Supplied Keyword: Postnatal development; Author-Supplied Keyword: Rat; NAICS/Industry Codes: 424610 Plastics Materials and Basic Forms and Shapes Merchant Wholesalers; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rui-Sheng Wang
AU - Ohtani, Katsumi
AU - Suda, Megumi
AU - Nakajima, Tamie
T1 - Inhibitory Effect of Ethylene Glycol Monoethyl Ether on Rat Sperm Motion.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 665
EP - 668
SN - 00198366
AB - The article presents the study which examines the inhibitory effect of ethylene glycol monoethyl ether (EGEE) on rat sperm motion in Japan. A Hamilton-Thorne Sperm analyzer was used to investigate the change in motion of sperm from cauda epididymides and spermaducts, and the administration of EGEE for five weeks has decreased total and progressive motility of sperm. The study suggested that the metabolite of EGEE may directly affect the motion of mature sperm.
KW - Animal experimentation
KW - Methoxyethanol
KW - Reproductive toxicology
KW - Sperm motility
KW - Japan
KW - Ethoxyacetic acid
KW - Ethylene glycol monoethyl ether
KW - Reproductive toxicity
KW - Sperm motion
N1 - Accession Number: 25253776; Rui-Sheng Wang 1; Ohtani, Katsumi 1; Suda, Megumi 1; Nakajima, Tamie 2; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Occupational and Environmental Health, Nagoya University, Nagoya 466-8550, Japan; Issue Info: 2006, Vol. 44 Issue 4, p665; Thesaurus Term: Animal experimentation; Subject Term: Methoxyethanol; Subject Term: Reproductive toxicology; Subject Term: Sperm motility; Subject: Japan; Author-Supplied Keyword: Ethoxyacetic acid; Author-Supplied Keyword: Ethylene glycol monoethyl ether; Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Sperm motion; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Takahashi, Masaya
AU - Iwakiri, Kuzuyuki
AU - Sotoyama, Midori
AU - Hirata, Mamoru
AU - Hisagana, Naomi
T1 - Arm Pain and Daytime Sleepiness among Nursing Home Employees.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 669
EP - 673
SN - 00198366
AB - The article presents the study which investigates the relationship between musculoskeletal disorder and sleep problems in Japan. Self-reported data on body pain, sleep disturbances, daytime sleepiness and the level of workload were collected from 98 employees at three nursing homes. The study suggested that arm pain is associated with elevated sleep propensity/fatigue in nursing home work.
KW - DISEASES
KW - Industrial hygiene
KW - Musculoskeletal system
KW - Sleep disorders
KW - Pain
KW - Drowsiness
KW - Nursing home employees
KW - Japan
KW - Daytime sleepiness
KW - Epworth sleepiness scale
KW - Musculoskeletal disorders
KW - Nursing homes
N1 - Accession Number: 25253777; Takahashi, Masaya 1; Iwakiri, Kuzuyuki 1; Sotoyama, Midori 1; Hirata, Mamoru 1; Hisagana, Naomi 2; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Center for Campus Health and Environment, Aichi University of Education, Hirosawa 1, Igaya-cho, Kariya, Aichi 448-8542, Japan; Issue Info: 2006, Vol. 44 Issue 4, p669; Thesaurus Term: DISEASES; Thesaurus Term: Industrial hygiene; Subject Term: Musculoskeletal system; Subject Term: Sleep disorders; Subject Term: Pain; Subject Term: Drowsiness; Subject Term: Nursing home employees; Subject: Japan; Author-Supplied Keyword: Daytime sleepiness; Author-Supplied Keyword: Epworth sleepiness scale; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Nursing homes; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Otsuka, Fuminori
AU - Komatsu-Okugaito, Miho
AU - Koizumi, Shinji
AU - Ohsawa, Motoyasu
T1 - Analysis of Human Proteins that Have an Affinity to Heavy Metals by Metal-Chelating Column Chromatography.
JO - Industrial Health
JF - Industrial Health
Y1 - 2006/10//
VL - 44
IS - 4
M3 - Article
SP - 674
EP - 678
SN - 00198366
AB - The article presents the study which examines human proteins that have an affinity to heavy metals by metal-chelating column chromatography in Japan. Protein samples prepared from HeLa cells were applied to the zinc- (Zn) or cadmium- (Cd) chelating column. The 36-kDA protein has an affinity to both Zn and Cd, which indicated the possibility that Cd can exchange essential Zn. The findings suggested that the established method is useful for the target protein screening.
KW - Cadmium
KW - Heavy metals
KW - Chromatographic analysis
KW - Zinc
KW - HeLa cells
KW - Proteins
KW - Japan
KW - Fluorography
KW - Metal-chelating column
KW - Silver staining
N1 - Accession Number: 25253778; Otsuka, Fuminori 1; Komatsu-Okugaito, Miho 1; Koizumi, Shinji 2; Ohsawa, Motoyasu 1; Affiliations: 1: Department of Molecular Environmental Health, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan; 2: Department of Health Effects Research, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2006, Vol. 44 Issue 4, p674; Thesaurus Term: Cadmium; Thesaurus Term: Heavy metals; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Zinc; Subject Term: HeLa cells; Subject Term: Proteins; Subject: Japan; Author-Supplied Keyword: Fluorography; Author-Supplied Keyword: Metal-chelating column; Author-Supplied Keyword: Silver staining; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shih-Houng Young
AU - Roberts, Jenny
AU - Antonini, James
T1 - Pulmonary Exposure to 1 → 3- β -Glucan Alters Adaptive Immune Responses in Rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2006/10//
VL - 18
IS - 11
M3 - Article
SP - 865
EP - 874
SN - 08958378
AB - 1 → 3- β -Glucans have been associated with increased pulmonary inflammation in fungal-related indoor air problems. Epidemiological studies have shown a correlation between increases in T-cell proliferation and decreases in CD4 + /CD8 + ratio after exposure to fungi. The objective of the present investigation was to determine the mechanisms by which 1 → 3- β -glucans affect immune responses using an animal model. Rats received a single dose of zymosan A (2.5 mg/kg body weight) via intratracheal instillation (IT) and were euthanized on days 1, 4, 6, 8, and 10 post IT. Bronchoalveolar lavage was performed at each time point post-IT. Inflammation and lung injury were assessed by measuring neutrophil infiltration into bronchoalveolar lavage fluid (BALF) and by measuring albumin and lactate dehydrogenase levels in BALF, respectively. Alveolar macrophage activation was determined by chemiluminescence. Immune response was characterized via immunophenotyping of bronchoalveolar lavage cells and lymphocytes isolated from the lung-associated lymph nodes. Upon challenge with zymosan, rats exhibited increased inflammation and injury at early time points (days 1 and 4) post IT exposure. Although elevations in neutrophil infiltration and chemiluminescence had returned to control levels on day 4, lymphocytes recovered from lung-associated lymph nodes continued to proliferate and reached a maximum on day 6. The CD4 + /CD8 + T cell ratio from lymph nodes was lower in zymosan-treated rats than in control rats. Zymosan treatment increased tumor necrosis factor (TNF)- α , interleukin (IL)-6, IL-10, and IL-12p70 secretion in BALF on day 1. In summary, rats exposed to zymosan had an increase in acute inflammation, and the altered lymphocyte profiles were consistent with the findings of epidemiology studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Glucans
KW - Immune response
KW - Rats
KW - Lung diseases
KW - T cells
N1 - Accession Number: 22088795; Shih-Houng Young 1; Email Address: sby5@cdco.gov; Roberts, Jenny 1; Antonini, James 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Oct2006, Vol. 18 Issue 11, p865; Thesaurus Term: Glucans; Thesaurus Term: Immune response; Subject Term: Rats; Subject Term: Lung diseases; Subject Term: T cells; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vaught, Charles
AU - Mallett, Launa
AU - Brnich, Michael J.
AU - Reinke, Dana
AU - Kowalski-Trakofler, Kathleen M.
AU - Cole, Henry P.
T1 - Knowledge management and transfer for mine emergency response.
JO - International Journal of Emergency Management
JF - International Journal of Emergency Management
Y1 - 2006/10//
VL - 3
IS - 2/3
M3 - Article
SP - 6
EP - 6
SN - 14714825
AB - The article presents information on how the U.S. coal mining organizations are losing the knowledge to tackle emergencies. The authors' observes that knowledge management provides an useful perspective to the problem. The article also examines National Institute for Occupational Safety and Health's research that has attempted to use such an alternative knowledge management approach to help potential mine emergency responders.
KW - EMERGENCY management
KW - KNOWLEDGE management
KW - INDUSTRIAL safety
KW - COAL mine accidents
KW - UNITED States
KW - coal mining
KW - computer simulation
KW - emergency management
KW - emergency responses
KW - knowledge management
KW - knowledge transfer
KW - narrative
KW - training
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 24150680; Vaught, Charles 1; Mallett, Launa 1; Brnich, Michael J. 1; Reinke, Dana 1; Kowalski-Trakofler, Kathleen M. 1; Cole, Henry P. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA.; 2: University of Kentucky, 1141 Red Mile Road, Suite 102, Lexington, KY 40504, USA.; Issue Info: 2006, Vol. 3 Issue 2/3, p6; Thesaurus Term: EMERGENCY management; Thesaurus Term: KNOWLEDGE management; Thesaurus Term: INDUSTRIAL safety; Subject Term: COAL mine accidents; Subject: UNITED States; Author-Supplied Keyword: coal mining; Author-Supplied Keyword: computer simulation; Author-Supplied Keyword: emergency management; Author-Supplied Keyword: emergency responses; Author-Supplied Keyword: knowledge management; Author-Supplied Keyword: knowledge transfer; Author-Supplied Keyword: narrative; Author-Supplied Keyword: training ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 1p; Document Type: Article
L3 - 10.1504/IJEM.2006.011167
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Koturbash, Igor
AU - Baker, Mike
AU - Loree, Jonathan
AU - Kutanzi, Kristy
AU - Hudson, Darryl
AU - Pogribny, Igor
AU - Sedelnikova, Olga
AU - Bonner, William
AU - Kovalchuk, Olga
T1 - Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
Y1 - 2006/10//
VL - 66
IS - 2
M3 - Article
SP - 327
EP - 330
SN - 03603016
AB - Purpose: Although modern cancer radiation therapy has led to increased patient survival rates, the risk of radiation treatment-related complications is becoming a growing problem. Among various complications, radiation also poses a threat to the progeny of exposed parents. It causes transgenerational genome instability that is linked to transgenerational carcinogenesis. Although the occurrence of transgenerational genome instability, which manifests as elevated delayed and nontargeted mutation, has been well documented, the mechanisms by which it arises remain obscure. We hypothesized that epigenetic alterations may play a pivotal role in the molecular etiology of transgenerational genome instability. Methods and Materials: We studied the levels of cytosine DNA methylation in somatic tissues of unexposed offspring upon maternal, paternal, or combined parental exposure. Results: We observed a significant loss of global cytosine DNA methylation in the thymus tissue of the offspring upon combined parental exposure. The loss of DNA methylation was paralleled by a significant decrease in the levels of maintenance (DNMT1) and de novo methyltransferases DNMT3a and 3b and methyl-CpG–binding protein MeCP2. Along with profound changes in DNA methylation, we noted a significant accumulation of DNA strand breaks in thymus, which is a radiation carcinogenesis target organ. Conclusions: The observed changes were indicative of a profound epigenetic dysregulation in the offspring, which in turn could lead to genome destabilization and possibly could serve as precursor for transgenerational carcinogenesis. Future studies are clearly needed to address the cellular and carcinogenic repercussions of those changes. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - DNA
KW - GENETICS
KW - CANCER patients
KW - DNA damage
KW - DNA methylation
KW - Epigenetics
KW - Radiation
KW - Transgeneration genome instability
N1 - Accession Number: 22278878; Koturbash, Igor 1 Baker, Mike 1 Loree, Jonathan 1 Kutanzi, Kristy 1 Hudson, Darryl 1 Pogribny, Igor 2 Sedelnikova, Olga 3 Bonner, William 3 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 3: Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Source Info: Oct2006, Vol. 66 Issue 2, p327; Subject Term: CANCER treatment; Subject Term: DNA; Subject Term: GENETICS; Subject Term: CANCER patients; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Epigenetics; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: Transgeneration genome instability; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijrobp.2006.06.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104743488
T1 - Young, black, and male in foster care: relationship of negative social contextual experiences to factors relevant to mental health service delivery.
AU - Scott Jr, Lionel D
AU - Davis, Larry E
AU - Scott, Lionel D Jr
Y1 - 2006/10//
N1 - Accession Number: 104743488. Language: English. Entry Date: 20110610. Revision Date: 20161114. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: R03 MH067124-02/MH/NIMH NIH HHS/United States. NLM UID: 7808986.
KW - Affect
KW - Blacks -- Psychosocial Factors
KW - Foster Home Care -- Statistics and Numerical Data
KW - Mental Disorders -- Epidemiology
KW - Mental Disorders -- Therapy
KW - Mental Health Services -- Utilization
KW - Social Environment
KW - Trust
KW - Adolescence
KW - Blacks -- Statistics and Numerical Data
KW - Attitude of Health Personnel
KW - Cross Sectional Studies
KW - Culture
KW - Human
KW - Male
KW - Mental Health Services -- Administration
KW - Missouri
KW - Patient Attitudes
KW - Questionnaires
SP - 721
EP - 736
JO - Journal of Adolescence
JF - Journal of Adolescence
JA - J ADOLESC
VL - 29
IS - 5
CY - Burlington, Massachusetts
PB - Academic Press Inc.
AB - Among a small, cross-sectional sample of young Black males transitioning from foster care (n=74), this study explored the relationship of their negative social contextual experiences to two factors relevant to the delivery of mental health services to them: cultural mistrust of mental health professionals and attitudes toward seeking professional help. Three domains of young Black male's negative social contextual experiences were measured: proximal negative experiences, distal negative experiences, and negative imagery experiences. Results of multivariate analysis of covariance (MANCOVA) controlling for custody status, counselling status and history, and psychiatric history showed that young Black males reporting a high frequency of negative social contextual experiences reported significantly greater cultural mistrust of mental health professionals and significantly less positive attitudes toward seeking professional help for mental health problems than young Black males reporting a low frequency of negative social contextual experiences. Implications and future research directions are discussed.
SN - 0140-1971
AD - Washington University in St. Louis, Center for Mental Health Services Research, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130, USA
AD - Washington University in St. Louis, Center for Mental Health Services Research, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130, USA. iscottjr@gsu.edu
U2 - PMID: 16364428.
DO - 10.1016/j.adolescence.2005.11.002
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Loyo-Berríos, Nilsa I.
AU - Orengo, Juan C.
AU - Serrano-Rodríguez, Ruby A.
T1 - Childhood Asthma Prevalence in Northern Puerto Rico, the Rio Grande, and Loíza Experience
JO - Journal of Asthma
JF - Journal of Asthma
Y1 - 2006/10//
VL - 43
IS - 8
M3 - Article
SP - 619
EP - 624
SN - 02770903
AB - Objective. Childhood asthma is highly prevalent in some areas of Puerto Rico. The objective of this study was to estimate the prevalence of asthma in two municipalities of Northern Puerto Rico. Methods. Children 6 to 7 and 13 to 14 years of age participated in the school-based cross-sectional study. Results. A total of 1,467 elementary school students and 1,334 junior-high school students were included in the survey. A high prevalence of asthma was observed; 46% in elementary schools and 24% in junior-high schools. In elementary schools, family history of asthma (FHA) was associated with ever wheezed (PR = 2.00, 95%CI 1.59, 2.52), wheeze during last year (PR = 2.02, 95%CI 1.54, 2.62), and asthma (PR = 2.33, 95%CI 1.86, 2.92). For junior-high schools FHA was associated with ever wheezed (PR = 2.01, 95%CI 1.56, 2.57), wheeze during previous year (PR = 2.00, 95%CI 1.47, 2.73), and asthma (PR = 2.72, 95%CI 2.06, 3.60). Conclusions. This study showed a high prevalence of asthma and related symptoms in Northern Puerto Rico. FHA was strongly associated with asthma and its symptoms. Further research is recommended to look at genetics, sensitivity levels, indoor and outdoor pollution, and gene-environment interactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASTHMA in children
KW - SYMPTOMS in children
KW - WHEEZE
KW - HEREDITY
KW - HUMAN genetics
KW - SCHOOL children
KW - HEALTH surveys
KW - childhood asthma
KW - family history
KW - prevalence
KW - PUERTO Rico
KW - wheezing illness
N1 - Accession Number: 22725019; Loyo-Berríos, Nilsa I. 1 Orengo, Juan C. 2 Serrano-Rodríguez, Ruby A. 3; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Post-Market Surveillance, Epidemiology Branch, Rockville, Maryland, USA 2: Ponce School of Medicine, Public Health Program, Ponce, Puerto Rico 3: Puerto Rico Department of Health, Behavioral Risk Factor Surveillance System, San Juan, Puerto Ric; Source Info: Oct2006, Vol. 43 Issue 8, p619; Subject Term: ASTHMA in children; Subject Term: SYMPTOMS in children; Subject Term: WHEEZE; Subject Term: HEREDITY; Subject Term: HUMAN genetics; Subject Term: SCHOOL children; Subject Term: HEALTH surveys; Author-Supplied Keyword: childhood asthma; Author-Supplied Keyword: family history; Author-Supplied Keyword: prevalence; Author-Supplied Keyword: PUERTO Rico; Author-Supplied Keyword: wheezing illness; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/02770900600878693
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22725019&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang Xia
AU - Qiao Meng
AU - Zongxian Cao
AU - Xianglin Shi
AU - Bing-Hua Jiang
T1 - Regulation of angiogenesis and tumor growth by p110 Alpha and AKT1 via VEGF expression.
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
Y1 - 2006/10//
VL - 209
IS - 1
M3 - Article
SP - 56
EP - 66
SN - 00219541
AB - Recent studies demonstrate that PI3K activation and PTEN mutation are frequently found in many human cancer cells and tissues. However, the mechanism of PI3K signaling in human cancer tumorigenesis remains to be elucidated. In this study we specifically downregulated p110α expression in ovarian cancer cells using siRNA interference. We found that p110α downregulation greatly decreased ovarian tumor growth and angiogenesis, and that p110α siRNA inhibited VEGF expression through decreasing hypoxia-inducible factor 1α expression in both ovarian cancer cells and tumor tissues. To determine the downstream targets of PI3K in regulating tumor growth and angiogenesis, we find that AKT1 is a major downstream mediator for regulating tumor growth, angiogenesis, and VEGF expression. These data show that p110α and AKT1 play an important role in tumor growth by inducing angiogenesis and by increasing HIF-1α and VEGF expression. This work provides a better understanding of the molecular mechanism of human cancer induced by the activation of PI3K signaling. J. Cell. Physiol. 209: 56–66, 2006. © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cellular Physiology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEOVASCULARIZATION
KW - TUMORS -- Growth
KW - CANCER cells
KW - GENE expression
KW - MUTATION (Biology)
KW - CELLULAR pathology
N1 - Accession Number: 21786453; Chang Xia 1 Qiao Meng 1 Zongxian Cao 1 Xianglin Shi 2 Bing-Hua Jiang 1; Email Address: bhjiang@hsc.wvu.edu; Affiliation: 1: Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Oct2006, Vol. 209 Issue 1, p56; Subject Term: NEOVASCULARIZATION; Subject Term: TUMORS -- Growth; Subject Term: CANCER cells; Subject Term: GENE expression; Subject Term: MUTATION (Biology); Subject Term: CELLULAR pathology; Number of Pages: 11p; Illustrations: 2 Color Photographs, 1 Diagram, 6 Graphs; Document Type: Article
L3 - 10.1002/jcp.20707
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106241117
T1 - Evolution and future of preclinical testing for endovascular grafts.
AU - Abel DB
AU - Dehdashtian MM
AU - Rodger ST
AU - Smith AC
AU - Smith LJ
AU - Waninger MS
Y1 - 2006/10//
N1 - Accession Number: 106241117. Language: English. Entry Date: 20070223. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 100896915.
KW - Grafts
KW - Vascular Surgery
KW - Animal Studies
KW - Seminars and Workshops
KW - United States Food and Drug Administration
SP - 649
EP - 659
JO - Journal of Endovascular Therapy (Allen Press Publishing Services Inc.)
JF - Journal of Endovascular Therapy (Allen Press Publishing Services Inc.)
JA - J ENDOVASC THER
VL - 13
IS - 5
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - The preclinical testing of endovascular grafts has evolved significantly since the creation and early testing of these devices; however, there are continued limitations in using preclinical testing to predict clinical performance. Early testing was conducted in the absence of standards and guidance specific to endovascular grafts, and references available for vascular grafts and stents did not adequately account for the complexity of endovascular graft systems. Failure of early-generation devices suggested that the testing being conducted was inadequate and that there was a lack of understanding of the in vivo environment. These concerns led to several efforts to improve preclinical testing. The Food and Drug Administration (FDA) sponsored a workshop to discuss the limitations inherent in testing of endovascular grafts, and an ISO standard for endovascular grafts was developed. Publication of the standard in 2003 succeeded in standardizing testing and reporting across device manufacturers; however, several clinical failure modes, such as migration and stent fractures, continued to be unpredicted by current preclinical testing. This, coupled with knowledge gained from additional clinical experience, led the FDA to hold a second workshop to discuss the benefits and limitations of current testing and propose future testing that may better predict device performance. This workshop was successful in accurately describing past testing, determining what has been learned, identifying issues that have not been adequately addressed, proposing modifications to address these limitations, and discussing how the proposed modifications should be implemented. While significant progress has been made in endovascular graft testing, continued collaboration among industry, academia, regulators, and clinicians will provide continued improvement in the predictability of device performance.
SN - 1526-6028
AD - Food and Drug Administration, CDRH/ODE/DCD/PVDB, 9200 Corporate Blvd., HFZ-450, Rockville, MD 20850; dorothy.abel@fda.hhs.gov
U2 - PMID: 17042666.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106241117&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106364217
T1 - AHRQ commentary. The third National reports on Healthcare Quality and Disparities in the United States: national data for targeting improvements.
AU - Hand MM
AU - Chesley FD Jr.
AU - Ho KK
AU - Clancy CM
Y1 - 2006/10//Oct-Dec2006
N1 - Accession Number: 106364217. Language: English. Entry Date: 20061124. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9200672.
KW - Quality of Health Care -- United States
KW - Health Services Accessibility
KW - Hispanics
KW - Patient Safety
KW - Quality Improvement
KW - Race Factors
KW - Reports
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 283
EP - 289
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 21
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; mary.hand@ahrq.hhs.gov
U2 - PMID: 16985394.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106364217&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Kavanaugh, Claudine
AU - Seifried, Harold
AU - Ellwood, Kathleen
AU - Yetley, Elizabeth
AU - Swanson, Christine
AU - Milner, John
T1 - A Research Agenda for Biomarkers as Indicators of Cancer Risk Reduction Following Dietary Manipulation.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2006/10//
VL - 136
IS - 10
M3 - Abstract
SP - 2666S
EP - 2667S
SN - 00223166
AB - An abstract of the article "A Research Agenda for Biomarkers as Indicators of Cancer Risk Reduction Following Dietary Manipulation," by Claudine Kavanaugh, Harold Seifried, Kathleen Ellwood, Elizabeth Yetley, Christine Swanson, and John Milner is presented.
KW - BIOCHEMICAL markers
N1 - Accession Number: 22644765; Kavanaugh, Claudine 1 Seifried, Harold 2; Email Address: hs41s@nih.gov Ellwood, Kathleen 1 Yetley, Elizabeth 3 Swanson, Christine 3 Milner, John 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740 2: Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20852 3: Office of Dietary Supplements, National Institutes of Health, Rockville, MD 20852; Source Info: Oct2006, Vol. 136 Issue 10, p2666S; Subject Term: BIOCHEMICAL markers; Number of Pages: 2p; Document Type: Abstract
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22644765&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liden, Goran
AU - Harper, Martin
T1 - Analytical Performance Criteria.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/10//
VL - 3
IS - 10
M3 - Article
SP - 94
EP - 101
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article focuses on sampling convention, which defines sampling efficiency vs. aerodynamic diameter for inhalable dust in air. It states that sampling convention is intended to compare a sample with standard airborne concentration only if the standard has been established though studies. It highlights that local air speed is much less that one meter per second in most indoor workplaces, raising the whether inhalability at such low air speeds will be independent of air speed.
KW - Air
KW - Dust
KW - Respiration
KW - Speed
KW - Work environment
N1 - Accession Number: 75127716; Liden, Goran 1; Harper, Martin 2; Affiliations: 1: Stockholm University, Stockholm, Sweden; 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Oct2006, Vol. 3 Issue 10, p94; Thesaurus Term: Air; Thesaurus Term: Dust; Thesaurus Term: Respiration; Subject Term: Speed; Subject Term: Work environment; Number of Pages: 8p; Document Type: Article
L3 - 10.1080/15459620600920580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127716&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Boylstein, Randy
AU - Piacitelli, Chris
AU - Grote, Ardith
AU - Kanwal, Richard
AU - Kullman, Greg
AU - Kreiss, Kathleen
T1 - Diacetyl Emissions and Airborne Dust from Butter Flavorings Used in Microwave Popcorn Production.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2006/10//
VL - 3
IS - 10
M3 - Article
SP - 530
EP - 535
PB - Taylor & Francis Ltd
SN - 15459624
AB - In microwave popcorn workers, exposure to butter flavorings has been associated with fixed obstructive lung disease resembling bronchiolitis obliterans. Inhalation toxicology studies have shown severe respiratory effects in rats exposed to vapors from a paste butter flavoring, and to diacetyl, a diketone found in most butter flavorings. To gain a better understanding of worker exposures, we assessed diacetyl emissions and airborne dust levels from butter flavorings used by several microwave popcorn manufacturing companies. We heated bulk samples of 40 different butter flavorings (liquids, pastes, and powders) to approximately 50°C and used gas chromatography, with a mass selective detector, to measure the relative abundance of volatile organic compounds emitted. Air sampling was conducted for diacetyl and for total and respirable dust during the mixing of powder, liquid, or paste flavorings with heated soybean oil at a microwave popcorn plant. To further examine the potential for respiratory exposures to powders, we measured dust generated during different simulated methods of manual handling of several powder butter flavorings. Powder flavorings were found to give off much lower diacetyl emissions than pastes or liquids. The mean diacetyl emissions from liquids and pastes were 64 and 26 times larger, respectively, than the mean of diacetyl emissions from powders. The median diacetyl emissions from liquids and pastes were 364 and 72 times larger, respectively, than the median of diacetyl emissions from powders. Fourteen of 16 powders had diacetyl emissions that were lower than the diacetyl emissions from any liquid flavoring and from most paste flavorings. However, simulated handling of powder flavorings showed that a substantial amount of the airborne dust generated was of respirable size and could thus pose its own respiratory hazard. Companies that use butter flavorings should consider substituting flavorings with lower diacetyl emissions and the use of ventilation and enclosure engineering controls to minimize exposures. Until controls are fully implemented, companies should institute mandatory respiratory protection for all exposed workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Emissions (Air pollution)
KW - Dust
KW - Diacetyl
KW - Popcorn
KW - Butter
KW - bronchiolitis obliterans
KW - butter flavoring
KW - diacetyl
KW - microwave popcorn
N1 - Accession Number: 75127719; Boylstein, Randy 1; Piacitelli, Chris 1; Grote, Ardith 1; Kanwal, Richard 1; Kullman, Greg 1; Kreiss, Kathleen 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia; Issue Info: Oct2006, Vol. 3 Issue 10, p530; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Dust; Subject Term: Diacetyl; Subject Term: Popcorn; Subject Term: Butter; Author-Supplied Keyword: bronchiolitis obliterans; Author-Supplied Keyword: butter flavoring; Author-Supplied Keyword: diacetyl; Author-Supplied Keyword: microwave popcorn; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311512 Creamery Butter Manufacturing; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/15459620600909708
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127719&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106247440
T1 - Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn production.
AU - Boylstein R
AU - Piacitelli C
AU - Grote A
AU - Kanwal R
AU - Kullman G
AU - Kreiss K
Y1 - 2006/10//
N1 - Accession Number: 106247440. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D114-5. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Dust -- Analysis
KW - Flavoring Agents -- Analysis
KW - Food Handling -- Standards
KW - Ketones -- Analysis
KW - Occupational Exposure -- Standards
KW - Air Pollutants, Occupational
KW - Butter
KW - Chromatography, Gas
KW - Comparative Studies
KW - Education, Continuing (Credit)
KW - Microwaves
KW - Particle Size
KW - Human
SP - 530
EP - 535
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In microwave popcorn workers, exposure to butter flavorings has been associated with fixed obstructive lung disease resembling bronchiolitis obliterans. Inhalation toxicology studies have shown severe respiratory effects in rats exposed to vapors from a paste butter flavoring, and to diacetyl, a diketone found in most butter flavorings. To gain a better understanding of worker exposures, we assessed diacetyl emissions and airborne dust levels from butter flavorings used by several microwave popcorn manufacturing companies. We heated bulk samples of 40 different butter flavorings (liquids, pastes, and powders) to approximately 50 degrees C and used gas chromatography, with a mass selective detector, to measure the relative abundance of volatile organic compounds emitted. Air sampling was conducted for diacetyl and for total and respirable dust during the mixing of powder, liquid, or paste flavorings with heated soybean oil at a microwave popcorn plant. To further examine the potential for respiratory exposures to powders, we measured dust generated during different simulated methods of manual handling of several powder butter flavorings. Powder flavorings were found to give off much lower diacetyl emissions than pastes or liquids. The mean diacetyl emissions from liquids and pastes were 64 and 26 times larger, respectively, than the mean of diacetyl emissions from powders. The median diacetyl emissions from liquids and pastes were 364 and 72 times larger, respectively, than the median of diacetyl emissions from powders. Fourteen of 16 powders had diacetyl emissions that were lower than the diacetyl emissions from any liquid flavoring and from most paste flavorings. However, simulated handling of powder flavorings showed that a substantial amount of the airborne dust generated was of respirable size and could thus pose its own respiratory hazard. Companies that use butter flavorings should consider substituting flavorings with lower diacetyl emissions and the use of ventilation and enclosure engineering controls to minimize exposures. Until controls are fully implemented, companies should institute mandatory respiratory protection for all exposed workers.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. zig1@cdc.gov
U2 - PMID: 16998985.
DO - 10.1080/15459620600909708
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106247440&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kreiss, Kathleen
AU - Esfahani, Reza S.
AU - Antao, Vinicius C. S.
AU - Odencrantz, John
AU - Lezotte, Dennis C.
AU - Hoffman, Richard E.
T1 - Risk Factors for Asthma Among Cosmetology Professionals in Colorado.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2006/10//
VL - 48
IS - 10
M3 - Article
SP - 1062
EP - 1069
SN - 10762752
AB - The article presents a study which centers on the prevalence, work-attributable risks and tasks associated with asthma among cosmetology professionals. A random sample of 3, 035 licensees were taken as the subjects of the study. They were subjected for Student t test for continuous data and Fisher exact tests for categorical data. They were likewise administered using logistic regression models to investigate asthma. After analysis, it was revealed that the prevalence of physician-diagnosed asthma among the 1, 883 respondents was 9.3 percent. Considering the result, it was concluded that the increased risk of asthma with onset during employment among cosmetologists is probably attributable to their exposure to sensitizers and irritants in tasks demonstrated to be associated with asthma.
KW - ASTHMA
KW - HEALTH risk assessment
KW - RISK assessment
KW - DISEASES -- Risk factors
KW - COSMETOLOGISTS
KW - LUNG diseases
KW - COSMETOLOGY
KW - HEALTH
KW - RESEARCH
KW - INDUSTRIAL safety
N1 - Accession Number: 22877182; Kreiss, Kathleen 1,2; Email Address: kxk2@cdc.gov Esfahani, Reza S. 1 Antao, Vinicius C. S. 2 Odencrantz, John 2 Lezotte, Dennis C. 1 Hoffman, Richard E. 1,3; Affiliation: 1: Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: Colorado Department of Public Health and Environment, Denver, Colorado; Source Info: Oct2006, Vol. 48 Issue 10, p1062; Subject Term: ASTHMA; Subject Term: HEALTH risk assessment; Subject Term: RISK assessment; Subject Term: DISEASES -- Risk factors; Subject Term: COSMETOLOGISTS; Subject Term: LUNG diseases; Subject Term: COSMETOLOGY; Subject Term: HEALTH; Subject Term: RESEARCH; Subject Term: INDUSTRIAL safety; NAICS/Industry Codes: 611511 Cosmetology and Barber Schools; NAICS/Industry Codes: 812112 Beauty Salons; NAICS/Industry Codes: 812115 Beauty salons; NAICS/Industry Codes: 812116 Unisex hair salons; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1097/01.jom.0000237348.32645.eb
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22877182&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barbero, Ana M.
AU - Frasch, H. Frederick
T1 - Transcellular route of diffusion through stratum corneum: Results from finite element models.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2006/10//
VL - 95
IS - 10
M3 - Article
SP - 2186
EP - 2194
SN - 00223549
AB - Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (tlag) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n = 27) of hydrophilic compounds was compiled from the literature. Transcellular and lateral lipid diffusion pathways were modeled within a brick-and-mortar geometry representing fully hydrated human SC. Modeled tlag's for the lipid pathway are too brief to account for the experimental quantities, whereas the transcellular pathway with preferential corneocyte partitioning does account for them. Measured tlag's are highly correlated (p < 0.0001) with the compound's octanol-water partition coefficient, supporting the hypothesis of an aqueous-lipid partition mechanism in the permeation of hydrophilic compounds. The importance of the lag time for identifying the diffusion pathway is demonstrated. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95:2186–2194, 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERMEABILITY
KW - MATHEMATICAL models
KW - TRANSDERMAL medication
KW - SKIN absorption
KW - LIPIDS
KW - diffusion
KW - kin absorption
KW - lag time
KW - mathematical model
KW - partition coefficient
KW - permeability
KW - skin absorption
KW - transdermal
N1 - Accession Number: 22175810; Barbero, Ana M. 1 Frasch, H. Frederick 1; Email Address: HFrasch@cdc.gov; Affiliation: 1: Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Source Info: Oct2006, Vol. 95 Issue 10, p2186; Subject Term: PERMEABILITY; Subject Term: MATHEMATICAL models; Subject Term: TRANSDERMAL medication; Subject Term: SKIN absorption; Subject Term: LIPIDS; Author-Supplied Keyword: diffusion; Author-Supplied Keyword: kin absorption; Author-Supplied Keyword: lag time; Author-Supplied Keyword: mathematical model; Author-Supplied Keyword: partition coefficient; Author-Supplied Keyword: permeability; Author-Supplied Keyword: skin absorption; Author-Supplied Keyword: transdermal; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1002/jps.20695
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22175810&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106244264
T1 - Nonfatal all-terrain vehicle-related injuries to youths living on farms in the United States, 2001.
AU - Goldcamp EM
AU - Myers J
AU - Hendricks K
AU - Layne L
AU - Helmkamp J
Y1 - 2006///Fall2006
N1 - Accession Number: 106244264. Language: English. Entry Date: 20070302. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 8508122.
KW - Accidents -- Epidemiology
KW - Agriculture
KW - Vehicle Operation -- Adverse Effects -- In Adolescence
KW - Adolescence
KW - Child
KW - Confidence Intervals
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Self Report
KW - Sex Factors
KW - Survey Research
KW - Human
SP - 308
EP - 313
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 22
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0890-765X
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop 1808, Morgantown, WV 26505-2888; ehg8@cdc.gov
U2 - PMID: 17010027.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106244264&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MAHMOOD, IFTEKHAR
AU - MARTINEZ, M.
AU - HUNTER, R. P.
T1 - Interspecies allometric scaling. Part I: prediction of clearance in large animals.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/10//
VL - 29
IS - 5
M3 - Article
SP - 415
EP - 423
PB - Wiley-Blackwell
SN - 01407783
AB - Interspecies scaling is a useful tool for the prediction of pharmacokinetic parameters from animals to humans, and it is often used for estimating a first-time in human dose. The knowledge of pharmacokinetics in veterinary species is important for dosage selection, particularly in the treatment of large zoo animal species, such as elephants, giant cats and camels, for which pharmacokinetic data are scant. Therefore, the accuracy in clearance predictions in large animal species, with and without the use of correction factors (rule of exponents), and the impact of species selection in the prediction of clearance in large animal species was examined. Based upon this analysis, it was determined that there is a much larger risk of inaccuracies in the clearance estimates in large animal species when compared with that observed for humans. Unlike in humans, for large animal species, correction factors could not be applied because there was no trend between the exponents of simple allometry and the appropriate correction factor for improving our predictions. Nevertheless, we did see an indication that the exponents of simple allometry may alert us as to when the predicted clearance in the large animal may be underestimated or overpredicted. For example, if a large animal is included in the scaling, the predicted clearance in a large animal should be considered overestimated if the exponent of simple allometry is >1.3. Despite the potential for extrapolation error, the reality is that allometric scaling is needed across many veterinary practice situations, and therefore will be used. For this reason, it is important to consider mechanisms for reducing the risk of extrapolation errors that can seriously affect target animal safety, therapeutic response, or the accuracy of withdrawal time predictions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMALS -- Classification
KW - APPROXIMATION theory
KW - DRUG metabolism
KW - PHARMACOKINETICS
KW - ANIMAL species
KW - ZOO animals
KW - DEVELOPMENTAL biology
N1 - Accession Number: 22172235; MAHMOOD, IFTEKHAR 1; Email Address: mahmoodi@cder.fda.gov MARTINEZ, M. 2 HUNTER, R. P. 3; Affiliation: 1: Clinical Pharmacology and Toxicology Branch (HFD-579), Office of Drug Evaluation VI, Center for Drug Evaluation and Research, Food & Drug Administration, Rockville, MD 2: Division of Therapeutic Drugs for Food Animals (HFV-130), Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food & Drug Administration, Rockville, MD 3: Elanco Animal Health, A Division of Eli Lilly and Company, Veterinary Safety/ADME, Greenfield, IN, USA; Source Info: Oct2006, Vol. 29 Issue 5, p415; Subject Term: ANIMALS -- Classification; Subject Term: APPROXIMATION theory; Subject Term: DRUG metabolism; Subject Term: PHARMACOKINETICS; Subject Term: ANIMAL species; Subject Term: ZOO animals; Subject Term: DEVELOPMENTAL biology; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00786.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MARTINEZ, MARILYN
AU - MAHMOOD, I.
AU - HUNTER, R. P.
T1 - Interspecies allometric scaling: prediction of clearance in large animal species: Part II: mathematical considerations.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/10//
VL - 29
IS - 5
M3 - Article
SP - 425
EP - 432
PB - Wiley-Blackwell
SN - 01407783
AB - Interspecies scaling is a useful tool for the prediction of pharmacokinetic parameters from animals to humans, and it is often used for estimating a first-time in human dose. However, it is important to appreciate the mathematical underpinnings of this scaling procedure when using it to predict pharmacokinetic parameter values across animal species. When cautiously applied, allometry can be a tool for estimating clearance in veterinary species for the purpose of dosage selection. It is particularly valuable during the selection of dosages in large zoo animal species, such as elephants, large cats and camels, for which pharmacokinetic data are scant. In Part I, allometric predictions of clearance in large animal species were found to pose substantially greater risks of inaccuracies when compared with that observed for humans. In this report, we examine the factors influencing the accuracy of our clearance estimates from the perspective of the relationship between prediction error and such variables as the distribution of body weight values used in the regression analysis, the influence of a particular observation on the clearance estimate, and the ‘goodness of fit’ ( R2) of the regression line. Ultimately, these considerations are used to generate recommendations regarding the data to be included in the allometric prediction of clearance in large animal species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL species
KW - ANIMALS -- Classification
KW - PHARMACOKINETICS
KW - MATHEMATICAL statistics
KW - ZOO animals
KW - ANALYSIS of variance
KW - VETERINARY pharmacology
N1 - Accession Number: 22172234; MARTINEZ, MARILYN 1; Email Address: mmartin1@cvm.fda.gov MAHMOOD, I. 2 HUNTER, R. P. 3; Affiliation: 1: Division of Therapeutic Drugs for Food Animals (HFV-130), Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food & Drug Administration, Rockville 2: Clinical Pharmacology and Toxicology Branch (HFD-579), Office of Drug Evaluation VI. Center for Drug Evaluation and Research, Food & Drug Administration, Woodmont Office Center II, Rockville, MD 3: Elanco Animal Health, A Division of Eli Lilly and Company, Greenfield, IN, USA; Source Info: Oct2006, Vol. 29 Issue 5, p425; Subject Term: ANIMAL species; Subject Term: ANIMALS -- Classification; Subject Term: PHARMACOKINETICS; Subject Term: MATHEMATICAL statistics; Subject Term: ZOO animals; Subject Term: ANALYSIS of variance; Subject Term: VETERINARY pharmacology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 9 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00787.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cook, Judith A.
AU - Mulkern, Virginia
AU - Grey, Dennis D.
AU - Burke-Miller, Jane
AU - Blyler, Crystal R.
AU - Razzano, Lisa A.
AU - Onken, Steven J.
AU - Balser, Richard M.
AU - Gold, Paul B.
AU - Shafer, Michael S.
AU - Kaufmann, Caroline L.
AU - Donegan, Kate
AU - Chow, Clifton M.
AU - Steigman, Pamela A.
T1 - Effects of local unemployment rate on vocational outcomes in a randomized trial of supported employment for individuals with psychiatric disabilities.
JO - Journal of Vocational Rehabilitation
JF - Journal of Vocational Rehabilitation
Y1 - 2006/10//
VL - 25
IS - 2
M3 - Article
SP - 71
EP - 84
PB - IOS Press
SN - 10522263
AB - The purpose of this study was to explore the effects of local unemployment rates on evidence-based supported employment (SE) programs tailored for people with psychiatric disabilities. Participants (n=1,273) from 7 states in the US were randomly assigned to experimental SE or services as usual/comparison conditions and followed for 24 months. Mixed-effects random regression analysis found that both local unemployment rate and study condition were significant predictors of competitive employment and working 40 or more hours per month. An interaction between study condition and unemployment rate was found, in which participants in areas with low unemployment receiving best practice SE had consistently better outcomes than all others. However, even in areas with high unemployment, those who received evidence-based SE had outcomes superior to those in the control condition. This confirms the influence of local labor market forces on individuals with psychiatric disabilities participating in vocational rehabilitation programs. It also suggests that those who are attempting to return to work in areas with weak local economies are likely to fare especially poorly if they are not receiving high quality SE interventions. Thus, use of evidence-based SE can help to ameliorate the effects of high unemployment on work outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Vocational Rehabilitation is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEOPLE with disabilities -- Employment
KW - PEOPLE with mental disabilities
KW - VOCATIONAL rehabilitation
KW - VOCATIONAL guidance
KW - AIDS for people with disabilities
KW - UNEMPLOYMENT
KW - EXPERIMENTAL design
KW - REGRESSION analysis
KW - UNITED States
KW - Mental illness
KW - psychiatric disability
KW - supported employment
KW - unemployment rate
N1 - Accession Number: 23247935; Cook, Judith A. 1; Email Address: cook@ripco.com Mulkern, Virginia 2 Grey, Dennis D. 1 Burke-Miller, Jane 1 Blyler, Crystal R. 3 Razzano, Lisa A. 1 Onken, Steven J. 4 Balser, Richard M. 5 Gold, Paul B. 6 Shafer, Michael S. 7 Kaufmann, Caroline L. 8 Donegan, Kate 9 Chow, Clifton M. 2 Steigman, Pamela A. 1; Affiliation: 1: University of Illinois, Chicago Department of Psychiatry, Chicago, IL, USA 2: Human Services Research Institute, Cambridge, MA, USA 3: Center for Mental Health Services, Rockville, MD, USA 4: Columbia University School of Social Work, New York, NY, USA 5: Maine Medical Center, Portland, ME, USA 6: Medical University of South Carolina, Charleston, SC, USA 7: University of Arizona, Tucson, AZ, USA 8: Consumer Research and Advocacy, Pittsburgh, PA, USA 9: The Matrix Center, Horizon House, Philadelphia, PA, USA; Source Info: 2006, Vol. 25 Issue 2, p71; Subject Term: PEOPLE with disabilities -- Employment; Subject Term: PEOPLE with mental disabilities; Subject Term: VOCATIONAL rehabilitation; Subject Term: VOCATIONAL guidance; Subject Term: AIDS for people with disabilities; Subject Term: UNEMPLOYMENT; Subject Term: EXPERIMENTAL design; Subject Term: REGRESSION analysis; Subject Term: UNITED States; Author-Supplied Keyword: Mental illness; Author-Supplied Keyword: psychiatric disability; Author-Supplied Keyword: supported employment; Author-Supplied Keyword: unemployment rate; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 14p; Illustrations: 2 Diagrams, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cox, Shanna
AU - Posner, Samuel F.
AU - McPheeters, Melissa
AU - Jamieson, Denise J.
AU - Kourtis, Athena P.
AU - Meikle, Susan
T1 - Influenza and Pregnant Women: Hospitalization Burden, United States, 1998–2002.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2006/10//
VL - 15
IS - 8
M3 - Article
SP - 891
EP - 893
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - Women in later stages of pregnancy are at increased risk for serious influenza-related morbidity; thus, universal influenza vaccination of pregnant women is recommended. However, vaccine uptake in the United States has been suboptimal. We previously described the burden of severe influenza-related morbidity during pregnancy in the United States by examining hospitalizations of pregnant women with respiratory illness during influenza season. Nondelivery hospitalizations with respiratory illness had significantly longer lengths of stay than those without respiratory illness. Hospitalization characteristics associated with greater likelihood of respiratory illness were the presence of a high-risk condition for which influenza vaccination is recommended, Medicaid/Medicare as primary expected payer, and hospitalization in a rural area. These findings may be explained by these women being at higher risk of influenza-related morbidity or reflect disparities in receipt of influenza immunization. Universal vaccination of pregnant women to decrease influenza-related morbidity should be encouraged. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANCY complications
KW - RESEARCH
KW - INFLUENZA -- Complications
KW - HOSPITAL care
KW - MEDICAL care costs
KW - INFLUENZA -- Vaccination
KW - DEMOGRAPHIC surveys
KW - TREATMENT
KW - UNITED States
N1 - Accession Number: 22980331; Cox, Shanna 1,2 Posner, Samuel F. 1; Email Address: shps5@cdc.gov McPheeters, Melissa 3 Jamieson, Denise J. 1 Kourtis, Athena P. 1 Meikle, Susan 4; Affiliation: 1: Centers for Disease Control and Prevention, Division of Reproductive Health, Atlanta, Georgia 2: Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 3: University of Michigan Health System, Division of General Pediatrics, Ann Arbor, Michigan 4: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Oct2006, Vol. 15 Issue 8, p891; Subject Term: PREGNANCY complications; Subject Term: RESEARCH; Subject Term: INFLUENZA -- Complications; Subject Term: HOSPITAL care; Subject Term: MEDICAL care costs; Subject Term: INFLUENZA -- Vaccination; Subject Term: DEMOGRAPHIC surveys; Subject Term: TREATMENT; Subject Term: UNITED States; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1089/jwh.2006.15.891
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bellamy, Nikki D.
AU - Sale, Elizabeth
AU - Min Qi Wang
AU - Springer, J. Fred
AU - Rath, Susie
T1 - SPOKEN, BUT PERHAPS NOT HEARD: YOUTH PERCEPTIONS ON THE RELATIONSHIP WITH THEIR ADULT MENTORS.
JO - Journal of Youth Ministry
JF - Journal of Youth Ministry
Y1 - 2006///Fall2006
VL - 5
IS - 1
M3 - Article
SP - 57
EP - 75
PB - Association of Youth Ministry Educators
SN - 15410412
AB - The article discusses a study on the perceptions of the youth and their relationship with their mentors. Intervention of adults in youth mentoring helps in the prevention of behavioral problems like drug abuse and improves positive behaviors. Prescriptive and developmental approaches would help in structuring these relationships between adult mentors and the youth. The formulation of different formats in youth programs would encourage youth receptiveness to other intervention strategies.
KW - YOUTH
KW - MENTORING in Christian education
KW - MENTORING -- Research
KW - SPIRITUAL formation
KW - INTERPERSONAL relations in young adults
N1 - Accession Number: 23010806; Bellamy, Nikki D. 1 Sale, Elizabeth 2 Min Qi Wang 3 Springer, J. Fred 4 Rath, Susie 5; Affiliation: 1: Social Science Analyst, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services in Rockville, Maryland 2: Research Scientist, Department of Child and Family Mental Health Services, Missouri Institute of Mental Health in St. Louis, Missouri 3: Professor of Public and Community Health, University of Maryland in College Park, Maryland 4: Director of Research for EMT Associates, Inc. in Franklin, Tennessee 5: Research Associate for EMT Associates, Inc. in Folsom, California; Source Info: Fall2006, Vol. 5 Issue 1, p57; Subject Term: YOUTH; Subject Term: MENTORING in Christian education; Subject Term: MENTORING -- Research; Subject Term: SPIRITUAL formation; Subject Term: INTERPERSONAL relations in young adults; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brito, G.
AU - Andrade, J.M.
AU - Havel, J.
AU - Díaz, C.
AU - García, F.J.
AU - Peña-Méndez, E.M.
T1 - Classification of some heat-treated liver pastes according to container type, using heavy metals content and manufacturer’s data, by principal components analysis and potential curves
JO - Meat Science
JF - Meat Science
Y1 - 2006/10//
VL - 74
IS - 2
M3 - Article
SP - 296
EP - 302
SN - 03091740
AB - Abstract: A total of 115 pork liver pastes were randomly collected in local markets from different brands, countries and containers. The concentrations of nine heavy metals (Cu, Ni, Cd, Fe, Mn, Pb, Cr, Co and Zn), determined by atomic absorption spectrometry, and some qualitative variables described on the labelling constituted the data set. Chemometrics analysis was performed combining principal components analysis (PCA), factor analysis (FA) and typical classification techniques, such as linear discriminant analysis (LDA) and potential curves (PoCu) to classify pork liver pastes. Origin of the sample, manufacturer and effect of manufacturing process were taken into account to verify traceability, which is an important issue in food safety policies. [Copyright &y& Elsevier]
AB - Copyright of Meat Science is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEAT
KW - BILIARY tract
KW - MEAT industry
KW - ANIMAL products
KW - Chemometrics
KW - Meat products
KW - Multivariate data analysis
KW - Potential curves
KW - Principal components analysis
KW - Traceability
N1 - Accession Number: 21742247; Brito, G. 1,2 Andrade, J.M. 3 Havel, J. 4 Díaz, C. 2 García, F.J. 2 Peña-Méndez, E.M. 2; Email Address: empena@ull.es; Affiliation: 1: Department of Health, Canary Islands Public Health Service, Canary Government, 38004-S/C de Tenerife, Tenerife, Spain 2: Department of Analytical Chemistry, Nutrition and Food Science, University of La Laguna, 38071-La Laguna, Tenerife, Spain 3: Department of Analytical Chemistry, University A Coruña, Campus da Zapateira, E-15071-A Coruña, Spain 4: Department of Analytical Chemistry, Faculty of Science, Kotláršká 2, 611 37-Brno, Czech Republic; Source Info: Oct2006, Vol. 74 Issue 2, p296; Subject Term: MEAT; Subject Term: BILIARY tract; Subject Term: MEAT industry; Subject Term: ANIMAL products; Author-Supplied Keyword: Chemometrics; Author-Supplied Keyword: Meat products; Author-Supplied Keyword: Multivariate data analysis; Author-Supplied Keyword: Potential curves; Author-Supplied Keyword: Principal components analysis; Author-Supplied Keyword: Traceability; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311612 Meat Processed from Carcasses; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.meatsci.2006.03.024
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Putt, Karson S.
AU - Chen, Grace W.
AU - Pearson, Jennifer M.
AU - Sandhorst, Joseph S.
AU - Hoagland, Martin S.
AU - Jung-Taek Kwon
AU - Soon-Kyung Hwang
AU - Hua Jin
AU - Churchwell, Mona I
AU - Myung-Haing Cho
AU - Doerge, Daniel R.
AU - Helferich, William G.
AU - Hergenrother, Paul J.
T1 - Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
JO - Nature Chemical Biology
JF - Nature Chemical Biology
Y1 - 2006/10//
VL - 2
IS - 10
M3 - Article
SP - 543
EP - 550
SN - 15524450
AB - Mutation and aberrant expression of apoptotic proteins are hallmarks of cancer. These changes prevent proapoptotic signals from being transmitted to executioner caspases, thereby averting apoptotic death and allowing cellular proliferation. Caspase-3 is the key executioner caspase, and it exists as an inactive zymogen that is activated by upstream signals. Notably, concentrations of procaspase-3 in certain cancerous cells are significantly higher than those in noncancerous controls. Here we report the identification of a small molecule (PAC-1) that directly activates procaspase-3 to caspase-3 in vitro and induces apoptosis in cancerous cells isolated from primary colon tumors in a manner directly proportional to the concentration of procaspase-3 inside these cells. We found that PAC-1 retarded the growth of tumors in three different mouse models of cancer, including two models in which PAC-1 was administered orally. PAC-1 is the first small molecule known to directly activate procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. The direct activation of executioner caspases is an anticancer strategy that may prove beneficial in treating the many cancers in which procaspase-3 concentrations are elevated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Chemical Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - MOLECULES
KW - CANCER cells
KW - APOPTOSIS
KW - COLON cancer
KW - TUMORS
N1 - Accession Number: 22404857; Putt, Karson S. 1 Chen, Grace W. 2 Pearson, Jennifer M. 2 Sandhorst, Joseph S. 2 Hoagland, Martin S. 3 Jung-Taek Kwon 4 Soon-Kyung Hwang 4 Hua Jin 4 Churchwell, Mona I 5 Myung-Haing Cho 4 Doerge, Daniel R. 5 Helferich, William G. 3 Hergenrother, Paul J. 1,2; Email Address: hergenro@uiuc.edu; Affiliation: 1: Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA 2: Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA 3: Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois 61801, USA 4: Laboratory of Toxicology, College of Veterinary Medicine and Nano Systems Institute-National Core Research Center (NSI-NCRC), Seoul National University, Seoul 151-742, South Korea 5: US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72029, USA; Source Info: Oct2006, Vol. 2 Issue 10, p543; Subject Term: PROTEINS; Subject Term: MOLECULES; Subject Term: CANCER cells; Subject Term: APOPTOSIS; Subject Term: COLON cancer; Subject Term: TUMORS; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1038/nchembio814
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105847218
T1 - Topotecan in combination with cisplatin for the treatment of stage IVB recurrent, or persistent cervical cancer.
AU - Brave M
AU - Dagher R
AU - Farrell A
AU - Abraham S
AU - Ramchandani R
AU - Gobburu J
AU - Booth B
AU - Jiang X
AU - Sridhara R
AU - Justice R
AU - Pazdur R
Y1 - 2006/10//
N1 - Accession Number: 105847218. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8712059.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Cervix Neoplasms -- Drug Therapy
KW - Neoplasm Recurrence, Local -- Drug Therapy
KW - Topotecan -- Administration and Dosage
KW - Alkaloids -- Administration and Dosage
KW - Carcinoma, Squamous Cell
KW - Carcinoma, Squamous Cell -- Drug Therapy
KW - Cervix Neoplasms -- Pathology
KW - Cisplatin -- Administration and Dosage
KW - Clinical Trials
KW - Female
KW - Human
KW - Neoplasm Recurrence, Local -- Pathology
KW - Neoplasm Staging
KW - Survival
SP - 1401
EP - 1410
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 20
IS - 11
CY - Norwalk, Connecticut
PB - UBM Medica
AB - PURPOSE: Topotecan, a camptothecin analog previously approved for the treatment of ovarian cancer and small-cell lung cancer, was granted regular approval by the US Food and Drug Administration (FDA) on June 14, 2006, for use in combination with cisplatin to treat women with stage IVB, recurrent, or persistent carcinoma of the cervix not amenable to curative treatment with surgery and/or radiation therapy. The purpose of this summary is to review the database supporting this approval. EXPERIMENTAL DESIGN: In a randomized multicenter study enrolling 293 eligible patients, topotecan plus cisplatin (TC) was compared with cisplatin monotherapy. The TC regimen consisted of cisplatin 50 mg/m2 IV over 1 hour on day 1 and topotecan 0.75 mg/m2 IV over 30 minutes on days 1, 2, and 3 every 21 days. RESULTS: There was a clinically relevant and statistically significant improvement in overall survival in the TC treatment arm. Median overall survival was 9.4 months (95% confidence interval [CI]:7.9-11.9) in the TC arm, compared to 6.5 months (95% CI:5.8-8.8) with cisplatin alone. The unadjusted hazard ratio for overall survival between treatment arms was 0.76 (95% CI: 0.59-0.98, P = .033) favoring the combination arm. The most common toxicities with TC included myelosuppression, nausea and vomiting, mucositis, rash, and hepatotoxicity. CONCLUSIONS: This report describes the FDA's review supporting this first approval of a chemotherapeutic drug for advanced cervical cancer based on demonstration of a survival benefit.
SN - 0890-9091
AD - Office of Oncology Drug Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 17112001.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Denboba, Diana
AU - McPherson, Merle G.
AU - Kenney, Mary Kay
AU - Strickland, Bonnie
AU - Newacheck, Paul W.
T1 - Achieving Family and Provider Partnerships for Children With Special Health Care Needs.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/10//
VL - 118
IS - 4
M3 - Article
SP - 1607
EP - 1615
SN - 00314005
AB - BACKGROUND. During the past 2 decades, family-centered care has evolved as the standard of care for children with special health care needs. A major principle of family-centered care is a strong partnership between the family and provider, working together to address issues and barriers t() accessing comprehensive care and related services. The federal Maternal and Child Health Bureau defines a positive family-provider partnership as a core program outcome. Our objective was to assess the extent to which families of children with special health care needs fee] as though they are treated as partners in decision-making by their doctors. METHODS. We analyzed the 2001 National Survey of Children With Special Health Care Needs, a nationally representative telephone survey of caretakers for 38 866 children with special health care needs. Bivariate and multivariate statistical methods were used to assess the frequency of meeting the partnership core outcome, as well as the demographic and socioeconomic predictors of meeting core outcome. We also examined the effect of partnership on indicators of access and well-being for children with special health care needs. RESULTS. Among children with special health care needs, 85.8% of families reported usually or always feeling like a partner in their child's care. However, living in poverty, minority racial and ethnic status, absence of health insurance, and depressed functional ability placed children with special health care needs and their families at elevated risk of being without a sense of partnership. We found that sense of partnership was associated with improved outcomes across a number of important health care measures, including missed school days, access to specially care, satisfaction with care, and unmet needs for child and family services. CONCLUSIONS. Results of the survey demonstrated that whereas most families of children with special health care needs feel they are partners in the care of their child, further work is needed, particularly for poor, uninsured, and minority children, as well as those with functional limitations. The survey results also demonstrate the importance of partnership; children whose care met the partnership core outcome experienced improved access to care and well-being. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILD care
KW - CHILDREN -- Health
KW - FAMILY nursing
KW - HEALTH insurance
KW - CHILDREN of minorities
KW - children with special health care needs
KW - family centered care
KW - family provider partnerships
KW - National Survey of Children with Special Health Care Needs
N1 - Accession Number: 22828864; Denboba, Diana 1; Email Address: denboba@hrsa.gov McPherson, Merle G. 1 Kenney, Mary Kay 2 Strickland, Bonnie 1 Newacheck, Paul W. 3; Affiliation: 1: Division of Services for Children with Special Health Care Needs, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD 2: Office of Data and Program Development, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD 3: Institute for Health Policy Studies and Department of Pediatrics, University of California, San Francisco, California; Source Info: Oct2006, Vol. 118 Issue 4, p1607; Subject Term: CHILD care; Subject Term: CHILDREN -- Health; Subject Term: FAMILY nursing; Subject Term: HEALTH insurance; Subject Term: CHILDREN of minorities; Author-Supplied Keyword: children with special health care needs; Author-Supplied Keyword: family centered care; Author-Supplied Keyword: family provider partnerships; Author-Supplied Keyword: National Survey of Children with Special Health Care Needs; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1542/peds.2006-0383
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22828864&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106219337
T1 - Achieving family and provider partnerships for children with special health care needs.
AU - Denboba D
AU - McPherson MG
AU - Kenney MK
AU - Strickland B
AU - Newacheck PW
Y1 - 2006/10//
N1 - Accession Number: 106219337. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child, Medically Fragile
KW - Decision Making
KW - Family Centered Care
KW - Professional-Family Relations
KW - Adolescence
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child
KW - Child Health Services
KW - Child, Preschool
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Health Services Accessibility
KW - Infant
KW - Infant, Newborn
KW - Insurance Coverage
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Multivariate Statistics
KW - Odds Ratio
KW - Social Class
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 1607
EP - 1615
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 118
IS - 4
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - BACKGROUND: During the past 2 decades, family-centered care has evolved as the standard of care for children with special health care needs. A major principle of family-centered care is a strong partnership between the family and provider, working together to address issues and barriers to accessing comprehensive care and related services. The federal Maternal and Child Health Bureau defines a positive family-provider partnership as a core program outcome. Our objective was to assess the extent to which families of children with special health care needs feel as though they are treated as partners in decision-making by their doctors. METHODS: We analyzed the 2001 National Survey of Children With Special Health Care Needs, a nationally representative telephone survey of caretakers for 38,866 children with special health care needs. Bivariate and multivariate statistical methods were used to assess the frequency of meeting the partnership core outcome, as well as the demographic and socioeconomic predictors of meeting core outcome. We also examined the effect of partnership on indicators of access and well-being for children with special health care needs. RESULTS: Among children with special health care needs, 85.8% of families reported usually or always feeling like a partner in their child's care. However, living in poverty, minority racial and ethnic status, absence of health insurance, and depressed functional ability placed children with special health care needs and their families at elevated risk of being without a sense of partnership. We found that sense of partnership was associated with improved outcomes across a number of important health care measures, including missed school days, access to specialty care, satisfaction with care, and unmet needs for child and family services. CONCLUSIONS: Results of the survey demonstrated that whereas most families of children with special health care needs feel they are partners in the care of their child, further work is needed, particularly for poor, uninsured, and minority children, as well as those with functional limitations. The survey results also demonstrate the importance of partnership; children whose care met the partnership core outcome experienced improved access to care and well-being.
SN - 0031-4005
AD - Division of Services for Children with Special Health Care Needs, Maternal and Child Health Bureau, Health Resources and Services Administration, Parklawn Building, 5600 Fishers La, Room 18A-18 Rockville, MD 20857, USA. ddenboba@hrsa.gov
U2 - PMID: 17015553.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106248504
T1 - Employment barriers for persons with psychiatric disabilities: update of a report for the president's commission.
AU - Cook JA
Y1 - 2006/10//
N1 - Accession Number: 106248504. Language: English. Entry Date: 20070309. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Employment -- Legislation and Jurisprudence -- United States
KW - Health Care Reform -- Legislation and Jurisprudence -- United States
KW - Mental Disorders -- Psychosocial Factors -- United States
KW - Mental Health Services -- Legislation and Jurisprudence -- United States
KW - Psychiatric Patients -- Legislation and Jurisprudence -- United States
KW - Public Policy
KW - Educational Status
KW - Health Policy
KW - Health Services Accessibility -- Economics
KW - Health Services Accessibility -- Legislation and Jurisprudence -- United States
KW - Insurance, Health
KW - Mental Health Services -- Economics
KW - Motivation
KW - Prejudice
KW - Rehabilitation, Vocational
KW - Self Concept
KW - Success
KW - Support, Psychosocial
KW - United States
SP - 1391
EP - 1405
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 57
IS - 10
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - A major public policy problem is the extremely low labor force participation of people with severe mental illness coupled with their overrepresentation on the public disability rolls. This situation is especially troubling given the existence of evidence-based practices designed to return them to the labor force. This article reviews research from the fields of disability, economics, health care, and labor studies to describe the nature of barriers to paid work and economic security for people with disabling mental disorders. These barriers include low educational attainment, unfavorable labor market dynamics, low productivity, lack of appropriate vocational and clinical services, labor force discrimination, failure of protective legislation, work disincentives caused by state and federal policies, poverty-level income, linkage of health care access to disability beneficiary status, and ineffective work incentive programs. The article concludes with a discussion of current policy initiatives in health care, mental health, and disability. Recommendations for a comprehensive system of services and supports to address multiple barriers are presented. These include access to affordable health care, including mental health treatment and prescription drug coverage; integrated clinical and vocational services; safe and stable housing that is not threatened by changes in earned income; remedial and postsecondary education and vocational training; benefits counseling and financial literacy education; economic security through asset development; legal aid for dealing with employment discrimination; peer support and self-help to enhance vocational self-image and encourage labor force attachment; and active involvement of U.S. business and employer communities.
SN - 1075-2730
AD - Director, Center on Mental Health Services Research, University of Chicago, 1601 West Taylor Street, 4th Floor M/C 913, Chicago, IL 60612. cook@ripco.com.
U2 - PMID: 17035556.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lester, Carolyn
AU - Temple, Mark
T1 - Health impact assessment and community involvement in land remediation decisions.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2006/10//
VL - 120
IS - 10
M3 - Article
SP - 915
EP - 922
SN - 00333506
AB - This paper describes a collaborative health impact assessment (HIA) of land remediation options at the site of a former smokeless fuel factory, where action had been delayed by conflict between stakeholders. The likely impacts of the processes involved on the physical and mental health of the community were examined in terms of the relevant scientific and medical literature, history of the site and evidence of local people. Although all remediation options were likely to have some adverse health effects, they could be mitigated by making choices based on the best evidence. The steering group concluded that the adverse effects of remediation would be relatively short term and could be justified by the medium- to long-term benefits of removing toxic substances. The HIA steering group's recommendations were accepted by the project working group, resulting in the resolution of tong-running conflict between the residents, activists and those responsible for site remediation, which has now commenced. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health (Elsevier) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - ENVIRONMENTAL remediation
KW - LAND use
KW - ENVIRONMENTAL health
KW - PUBLIC health
KW - Conflict resolution
KW - HIA
KW - Land remediation
N1 - Accession Number: 23225799; Lester, Carolyn 1; Email Address: carolyn.lester@nphs.wales.nhs.k Temple, Mark 1; Affiliation: 1: National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, U.K.; Source Info: Oct2006, Vol. 120 Issue 10, p915; Subject Term: HEALTH risk assessment; Subject Term: ENVIRONMENTAL remediation; Subject Term: LAND use; Subject Term: ENVIRONMENTAL health; Subject Term: PUBLIC health; Author-Supplied Keyword: Conflict resolution; Author-Supplied Keyword: HIA; Author-Supplied Keyword: Land remediation; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1016/j.puhe.2006.05.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23225799&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104745017
T1 - Health impact assessment and community involvement in land remediation decisions.
AU - Lester, Carolyn
AU - Temple, Mark
Y1 - 2006/10//
N1 - Accession Number: 104745017. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 0376507.
KW - Health Impact Assessment
KW - Health and Welfare Planning -- Administration
KW - Consumer Participation
KW - Environmental Health
KW - Environmental Pollution -- Standards
KW - Industry
KW - Cooperative Behavior
KW - Ammonia
KW - Breast Neoplasms -- Epidemiology
KW - Energy-Generating Resources
KW - Keratolytic Agents
KW - Hazardous Materials
KW - Lung Neoplasms -- Epidemiology
KW - Hydrocarbons
KW - Risk Assessment
KW - Wales
SP - 915
EP - 922
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 120
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, U.K. carolyn.lester@nphs.wales.nhs.uk
U2 - PMID: 16962621.
DO - 10.1016/j.puhe.2006.05.011
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Obi, E.
AU - Akunyili, Dora N.
AU - Ekpo, B.
AU - Orisakwe, Orish E.
T1 - Heavy metal hazards of Nigerian herbal remedies
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2006/10//
VL - 369
IS - 1-3
M3 - Article
SP - 35
EP - 41
SN - 00489697
AB - Abstract: The uses of herbal products are not regulated in Nigeria and in many low-income countries and are freely available to everyone. The safety of these herbal medicines is poorly understood. This study characterizes the content of cadmium, copper, iron, nickel, selenium, zinc, lead and mercury in a random sample of Nigerian traditional products. Ready-to-use herbal products were purchased from the open market and digested using HNO3.The heavy metal content of the digested filtrate was determined by atomic absorption spectrometry Uni-cam Model 929. The result showed that 100% of the samples contained elevated amounts of heavy metals. These data alert us to the possibility of heavy metal toxicity from herbal products in Nigeria. The public health hazards from ingestion of herbal medicines should be identified and disclosed by in-depth risk assessment studies. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBAL medicine
KW - HEAVY metals
KW - NATIVE element minerals
KW - NIGERIA
KW - Heavy metals
KW - herbal remedies
KW - public health
KW - toxicity
N1 - Accession Number: 22218944; Obi, E. 1 Akunyili, Dora N. 2 Ekpo, B. 3 Orisakwe, Orish E. 1; Email Address: eorish@yahoo.com; Affiliation: 1: Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria 2: National Agency of Food and Drug Administration and Control (NAFDAC), Lagos, Nigeria 3: Department of Biochemistry, College of Medical Sciences, Abia State University, Uturu, Nigeria; Source Info: Oct2006, Vol. 369 Issue 1-3, p35; Subject Term: HERBAL medicine; Subject Term: HEAVY metals; Subject Term: NATIVE element minerals; Subject Term: NIGERIA; Author-Supplied Keyword: Heavy metals; Author-Supplied Keyword: herbal remedies; Author-Supplied Keyword: public health; Author-Supplied Keyword: toxicity; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.scitotenv.2006.04.024
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mirfazaelian, Ahmad
AU - Kyu-Bong Kim
AU - Anand, Sathanandam S.
AU - Kim, Hyo J.
AU - Tornero-Velez, Rogelio
AU - Bruckner, James V.
AU - Fisher, Jeffrey W.
T1 - Development of a Physiologically Based Pharmacokinetic Model for Deltamethrin in the Adult Male Sprague-Dawley Rat.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/10//
VL - 93
IS - 2
M3 - Article
SP - 432
EP - 442
PB - Oxford University Press / USA
SN - 10966080
AB - Deltamethrin (DLT) is a type II pyrethroid insecticide widely used in agriculture and public health. DLT is a potent neurotoxin that is primarily cleared from the body by metabolism. To better understand the dosimetry of DLT in the central nervous system, a physiologically based pharmacokinetic (PBPK) model for DLT was constructed for the adult, male Sprague-Dawley rat that employed both flow-limited (brain, gastrointestinal [GI] tract, liver, and rapidly perfused tissues) and diffusion-limited (fat, blood/plasma, and slowly perfused tissues) rate equations. The blood was divided into plasma and erythrocytes. Cytochrome P450–mediated metabolism was accounted for in the liver and carboxylesterase (CaE)-mediated metabolism in plasma and liver. Serial blood, brain, and fat samples were taken for DLT analysis for up to 48 h after adult rats received 2 or 10 mg DLT/kg po. Hepatic biotransformation accounted for ∼ 78% of these administered doses. Plasma CaEs accounted for biotransformation of ∼ 8% of each dosage. Refined PBPK model forecasts compared favorably to the 2- and 10-mg/kg po blood, plasma, brain, and fat DLT profiles, as well as profiles subsequently obtained from adult rats given 1 mg/kg iv. DLT kinetic profiles extracted from published reports of oral and iv experiments were also used for verification of the model's simulations. There was generally good agreement in most instances between predicted and the limited amount of empirical data. It became clear from our modeling efforts that there is considerably more to be learned about processes that govern GI absorption and exsorption, transport, binding, brain uptake and egress, fat deposition, and systemic elimination of DLT and other pyrethroids. The current model can serve as a foundation for construction of models for other pyrethroids and can be improved as more definitive information on DLT kinetic processes becomes available. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pyrethroids
KW - Cytochrome P-450
KW - Biotransformation (Metabolism)
KW - Pharmacokinetics
KW - Rats as laboratory animals
KW - deltamethrin
KW - male Sprague- Dawley rat
KW - male Sprague-Dawley rat
KW - PBPK modeling
KW - pyrethroids
KW - toxicokinetics
N1 - Accession Number: 44406590; Mirfazaelian, Ahmad 1; Kyu-Bong Kim 2,3; Anand, Sathanandam S. 2; Kim, Hyo J. 2; Tornero-Velez, Rogelio 4; Bruckner, James V. 2; Fisher, Jeffrey W. 1; Email Address: jwfisher@uga.edu; Affiliations: 1: Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602-2102; 2: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602-2354; 3: Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, South Korea; 4: U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, North Carolina 27709; Issue Info: Oct2006, Vol. 93 Issue 2, p432; Thesaurus Term: Pyrethroids; Thesaurus Term: Cytochrome P-450; Thesaurus Term: Biotransformation (Metabolism); Subject Term: Pharmacokinetics; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: deltamethrin; Author-Supplied Keyword: male Sprague- Dawley rat; Author-Supplied Keyword: male Sprague-Dawley rat; Author-Supplied Keyword: PBPK modeling; Author-Supplied Keyword: pyrethroids; Author-Supplied Keyword: toxicokinetics; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 8 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfl056
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Darnell, Miriam E. R.
AU - Taylor, Deborah R.
T1 - Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products.
JO - Transfusion
JF - Transfusion
Y1 - 2006/10//
VL - 46
IS - 10
M3 - Article
SP - 1770
EP - 1777
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Severe acute respiratory syndrome coronavirus (SARS-CoV) has been detected in the blood of infected individuals, which may have the potential to contaminate donated blood and plasma-derived products in the event of a future outbreak. Effective methods for inactivating the SARS-CoV in protein solutions are described in this report. STUDY DESIGN AND METHODS: Heat, ultraviolet (UV) irradiation, octanoic acid, and solvent/detergent (S/D) methods were tested individually for their ability to inactivate SARS-CoV in protein solutions appropriately mimicking blood-derived products. Treated samples were tested for inactivation in a tissue culture growth assay. RESULTS: Viral inactivation by heat treatment at 60°C required 15 to 30 minutes to inactivate the SARS-CoV. UVC efficiently inactivated SARS-CoV in 40 minutes, whereas UVA required the addition of psoralen to enhance inactivation of the virus. The presence of bovine serum albumin limited the ability of UVC and UVA to inactivate SARS-CoV and octanoic acid treatment does not reduce the infectivity of SARS-CoV–spiked protein solutions. S/D treatment required 2, 4, and up to 24 hours for Triton X-100, Tween 80, and sodium cholate inactivation, respectively. CONCLUSION: Heat, UVC irradiation, and S/D treatments effectively inactivate SARS-CoV, whereas octanoic acid treatment is insufficient for inactivation of the virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD proteins
KW - SARS (Disease)
KW - TISSUE culture
KW - BLOOD plasma
KW - SERUM
KW - VIRUSES
KW - NUCLEAR physics
N1 - Accession Number: 22436482; Darnell, Miriam E. R. 1 Taylor, Deborah R. 1; Email Address: Deborah.Taylor@FDA.HHS.gov; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland; Source Info: Oct2006, Vol. 46 Issue 10, p1770; Subject Term: BLOOD proteins; Subject Term: SARS (Disease); Subject Term: TISSUE culture; Subject Term: BLOOD plasma; Subject Term: SERUM; Subject Term: VIRUSES; Subject Term: NUCLEAR physics; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 8p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1111/j.1537-2995.2006.00976.x
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Srinivasan, Kumar
AU - Lee, Sherwin
AU - Daniel, Sylvester
AU - Wood, Owen
AU - Akolkar, Pradip
AU - Hewlett, Indira
T1 - Performance of serological assays used to test blood from recent smallpox vaccinees.
JO - Transfusion
JF - Transfusion
Y1 - 2006/10//
VL - 46
IS - 10
M3 - Letter
SP - 1847
EP - 1848
PB - Wiley-Blackwell
SN - 00411132
AB - A letter to the editor is presented in response to the article about the performance of vaccination against influenza to test the donated blood.
KW - LETTERS to the editor
KW - VACCINATION
N1 - Accession Number: 22436477; Srinivasan, Kumar 1 Lee, Sherwin 1 Daniel, Sylvester 1 Wood, Owen 1 Akolkar, Pradip 1 Hewlett, Indira 1; Email Address: Indira.Hewlett@fda.hhs.gov; Affiliation: 1: Laboratory of Molecular Virology Division of Emerging and Transfusion Transmitted Diseases CBER, U.S. Food and Drug Administration Rockville, Maryland; Source Info: Oct2006, Vol. 46 Issue 10, p1847; Subject Term: LETTERS to the editor; Subject Term: VACCINATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1537-2995.2006.00982.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105849631
T1 - Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products.
AU - Darnell ME
AU - Taylor DR
AU - Darnell, Miriam E R
AU - Taylor, Deborah R
Y1 - 2006/10//
N1 - Accession Number: 105849631. Language: English. Entry Date: 20080314. Revision Date: 20161129. Publication Type: journal article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0417360.
KW - Acids, Acyclic -- Pharmacodynamics
KW - Microbiologic Phenomena -- Drug Effects
KW - Microbiologic Phenomena -- Radiation Effects
KW - Plasma
KW - SARS Virus
KW - Severe Acute Respiratory Syndrome -- Prevention and Control
KW - Ultraviolet Rays
KW - Animals
KW - Blood Donors
KW - Heat
KW - Primates
KW - Time Factors
KW - Animal Studies
SP - 1770
EP - 1777
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 46
IS - 10
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background: Severe acute respiratory syndrome coronavirus (SARS-CoV) has been detected in the blood of infected individuals, which may have the potential to contaminate donated blood and plasma-derived products in the event of a future outbreak. Effective methods for inactivating the SARS-CoV in protein solutions are described in this report.Study Design and Methods: Heat, ultraviolet (UV) irradiation, octanoic acid, and solvent/detergent (S/D) methods were tested individually for their ability to inactivate SARS-CoV in protein solutions appropriately mimicking blood-derived products. Treated samples were tested for inactivation in a tissue culture growth assay.Results: Viral inactivation by heat treatment at 60 degrees C required 15 to 30 minutes to inactivate the SARS-CoV. UVC efficiently inactivated SARS-CoV in 40 minutes, whereas UVA required the addition of psoralen to enhance inactivation of the virus. The presence of bovine serum albumin limited the ability of UVC and UVA to inactivate SARS-CoV and octanoic acid treatment does not reduce the infectivity of SARS-CoV-spiked protein solutions. S/D treatment required 2, 4, and up to 24 hours for Triton X-100, Tween 80, and sodium cholate inactivation, respectively.Conclusion: Heat, UVC irradiation, and S/D treatments effectively inactivate SARS-CoV, whereas octanoic acid treatment is insufficient for inactivation of the virus.
SN - 0041-1132
AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA
AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
U2 - PMID: 17002634.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105849631&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CONF
AU - Skinner, M.
AU - Mannucci, P.M.
AU - Farrugia, A.
AU - DiMichele, D.
AU - Bolton-Maggs, P.
AU - Burnouf, T.
AU - Sher, G.
AU - Armstrong, D.
AU - Rock, G.
AU - Barrowcliffe, T.
AU - Dodt, J.
AU - Soucie, M.
AU - Bryant, C.
AU - Chiasson, B.
AU - Weinstein, M.
AU - Page, D.
AU - O’Mahony, B.
AU - Bult, J.
AU - Rezende, S.
AU - Brooker, M.
T1 - Global Forum of the World Federation of Hemophilia, September 26–27, 2005, Montreal, Quebec, Canada
JO - Transfusion & Apheresis Science
JF - Transfusion & Apheresis Science
Y1 - 2006/10//
VL - 35
IS - 2
M3 - Proceeding
SP - 151
EP - 172
SN - 14730502
N1 - Accession Number: 23229286; Skinner, M. 1 Mannucci, P.M. 2 Farrugia, A. 3 DiMichele, D. 4 Bolton-Maggs, P. 5 Burnouf, T. 6 Sher, G. 7 Armstrong, D. 8 Rock, G. 9 Barrowcliffe, T. 10 Dodt, J. 11 Soucie, M. 12 Bryant, C. 13 Chiasson, B. 14 Weinstein, M. 4 Page, D. 15 O’Mahony, B. 16 Bult, J. 17 Rezende, S. 18 Brooker, M. 1; Email Address: mbrooker@wfh.org; Affiliation: 1: World Federation of Hemophilia 2: A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy 3: Australian Therapeutic Goods Administration 4: Food and Drug Administration, United States 5: Manchester Royal Infirmary, United Kingdom 6: Human Plasma Product services, Lille, France 7: Canadian Blood Services 8: Natal BioProducts Institute, South Africa 9: University of Ottawa, Canada 10: National Institute for Biological Standards and Control, United Kingdom 11: Paul Ehrlich Institute, Germany 12: Centers for Disease Control and Prevention, United States 13: Plasma Protein Purification System 14: Bayer Healthcare, Biological Products, Canada 15: Canadian Hemophilia Society 16: Irish Haemophilia Society 17: Plasma Proteins Therapeutics Association 18: Brazilian Ministry of Health; Source Info: Oct2006, Vol. 35 Issue 2, p151; Number of Pages: 22p; Document Type: Proceeding
L3 - 10.1016/j.transci.2006.07.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23229286&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2006-11676-004
AN - 2006-11676-004
AU - Scott, Lionel D. Jr.
AU - Davis, Larry E.
T1 - Young, black, and male in foster care: Relationship of negative social contextual experiences to factors relevant to mental health service delivery.
JF - Journal of Adolescence
JO - Journal of Adolescence
JA - J Adolesc
Y1 - 2006/10//
VL - 29
IS - 5
SP - 721
EP - 736
CY - Netherlands
PB - Elsevier Science
SN - 0140-1971
SN - 1095-9254
AD - Scott, Lionel D. Jr., 4504 Calvert Road, Huntsville, AL, US, 35816
N1 - Accession Number: 2006-11676-004. PMID: 16364428 Partial author list: First Author & Affiliation: Scott, Lionel D. Jr.; Washington University, Center for Mental Health Services Research, St. Louis, MO, US. Release Date: 20060925. Correction Date: 20170123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Foster Care; Health Care Delivery; Help Seeking Behavior; Psychosocial Factors; Racial and Ethnic Attitudes. Minor Descriptor: Blacks; Human Males; Mental Health Services; Trust (Social Behavior). Classification: Community & Social Services (3373). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Cultural Mistrust Inventory; Attitudes Toward Seeking Professional Psychological Help Scale; Black Male Experiences Measure DOI: 10.1037/t25837-000. Methodology: Empirical Study; Followup Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Oct, 2006.
AB - Among a small, cross-sectional sample of young Black males transitioning from foster care (n=74), this study explored the relationship of their negative social contextual experiences to two factors relevant to the delivery of mental health services to them: cultural mistrust of mental health professionals and attitudes toward seeking professional help. Three domains of young Black male's negative social contextual experiences were measured: proximal negative experiences, distal negative experiences, and negative imagery experiences. Results of multivariate analysis of covariance (MANCOVA) controlling for custody status, counselling status and history, and psychiatric history showed that young Black males reporting a high frequency of negative social contextual experiences reported significantly greater cultural mistrust of mental health professionals and significantly less positive attitudes toward seeking professional help for mental health problems than young Black males reporting a low frequency of negative social contextual experiences. Implications and future research directions are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - foster care
KW - negative social contextual experiences
KW - mental health service delivery
KW - cultural mistrust
KW - help seeking attitudes
KW - young Black males
KW - 2006
KW - Foster Care
KW - Health Care Delivery
KW - Help Seeking Behavior
KW - Psychosocial Factors
KW - Racial and Ethnic Attitudes
KW - Blacks
KW - Human Males
KW - Mental Health Services
KW - Trust (Social Behavior)
KW - 2006
U1 - Sponsor: National Institute of Mental Health. Grant: 5R03MH067124-02. Recipients: No recipient indicated
DO - 10.1016/j.adolescence.2005.11.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11676-004&site=ehost-live&scope=site
UR - iscottjr@gsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07321-002
AN - 2007-07321-002
AU - Cook, Judith A.
T1 - Employment barriers for persons with psychiatric disabilities: Update of a report for the President's Commission.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/10//
VL - 57
IS - 10
SP - 1391
EP - 1405
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Cook, Judith A., Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, 4th Floor M/C 913, Chicago, IL, US, 60612
N1 - Accession Number: 2007-07321-002. PMID: 17035556 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20070730. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employment Status; Health Care Costs; Income (Economic); Income Level; Mental Disorders. Minor Descriptor: Mental Health; Poverty. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 15. Issue Publication Date: Oct, 2006.
AB - A major public policy problem is the extremely low labor force participation of people with severe mental illness coupled with their overrepresentation on the public disability rolls. This situation is especially troubling given the existence of evidence-based practices designed to return them to the labor force. This article reviews research from the fields of disability, economics, health care, and labor studies to describe the nature of barriers to paid work and economic security for people with disabling mental disorders. These barriers include low educational attainment, unfavorable labor market dynamics, low productivity, lack of appropriate vocational and clinical services, labor force discrimination, failure of protective legislation, work disincentives caused by state and federal policies, poverty-level income, linkage of health care access to disability beneficiary status, and ineffective work incentive programs. The article concludes with a discussion of current policy initiatives in health care, mental health, and disability. Recommendations for a comprehensive system of services and supports to address multiple barriers are presented. These include access to affordable health care, including mental health treatment and prescription drug coverage; integrated clinical and vocational services; safe and stable housing that is not threatened by changes in earned income; remedial and post-secondary education and vocational training; benefits counseling and financial literacy education; economic security through asset development; legal aid for dealing with employment discrimination; peer support and self-help to enhance vocational self-image and encourage labor force attachment; and active involvement of U.S. business and employer communities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - employment barriers
KW - persons with psychiatric disabilities
KW - health care costs
KW - poverty
KW - income level
KW - 2006
KW - Employment Status
KW - Health Care Costs
KW - Income (Economic)
KW - Income Level
KW - Mental Disorders
KW - Mental Health
KW - Poverty
KW - 2006
U1 - Sponsor: US Department of Education, National Institute on Disability and Rehabilitation Research, US. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: Cooperative Agreement H133-B05-0003. Recipients: No recipient indicated
DO - 10.1176/appi.ps.57.10.1391
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07321-002&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07321-019
AN - 2007-07321-019
AU - Salzer, Mark S.
AU - Kaplan, Katy
AU - Atay, Joanne
T1 - State psychiatric hospital census after the 1999 Olmstead decision: Evidence of decelerating deinstitutionalization.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/10//
VL - 57
IS - 10
SP - 1501
EP - 1504
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Salzer, Mark S., Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Mental Health Policy and Services Research, 3535 Market Street, 3rd Floor, Philadelphia, PA, US, 19104
N1 - Accession Number: 2007-07321-019. PMID: 17035573 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Salzer, Mark S.; Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Mental Health Policy and Services Research, Philadelphia, PA, US. Release Date: 20070730. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Salzer, Mark S. Major Descriptor: Decision Making; Institutionalization; Psychiatric Hospitals. Classification: Inpatient & Hospital Services (3379). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Oct, 2006.
AB - Objective: The Supreme Court ruled in the 1999 Olmstead decision that 'unjustified isolation' of individuals with disabilities in institutions is a violation of the Americans With Disabilities Act. This study examined the extent to which state psychiatric hospital census across the United States has changed significantly post-Olmstead. Methods: Twenty years of national state hospital census data (1984-2003) were used to assess trends in the rate of declines from pre- to post-Olmstead periods. Data were organized into five four-year periods. Results: Steady declines in the hospital census nationally were found over all periods, with especially large decreases in the 1990s. However, when the percent change in hospital census in the two periods immediately before the Olmstead decision (between 1992-1995 and 1996-1999) were compared with the percent change in the periods immediately before and immediately after the Olmstead decision (between 1996-1999 and 2000-2003), an 8 percent decrease in the magnitude of decline was seen. Conclusions: State hospital census continues to decline but has slowed significantly during the post-Olmstead period. More study of the factors associated with this decline is needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric hospitals
KW - deinstitutionalization
KW - Olmstead decision
KW - 2006
KW - Decision Making
KW - Institutionalization
KW - Psychiatric Hospitals
KW - 2006
U1 - Sponsor: University of Pennsylvania, US. Grant: H133-B0311-09. Other Details: Collaborative on Community Integration. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Disability and Rehabilitation Research. Recipients: Salzer, Mark S. (Prin Inv)
DO - 10.1176/appi.ps.57.10.1501
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07321-019&site=ehost-live&scope=site
UR - salzer@mail.med.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07321-038
AN - 2007-07321-038
AU - Blyler, Crystal R.
T1 - Review of In recovery: The making of mental health policy.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/10//
VL - 57
IS - 10
SP - 1530
EP - 1530
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2007-07321-038. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Blyler, Crystal R.; Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, US. Release Date: 20070730. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Mental Health Services; Recovery (Disorders); Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Reviewed Item: Jacobson, Nora. In recovery: The making of mental health policy=Nashville, Tennessee, Vanderbilt University Press, 208 pages, $24.95 softcover; 2004. References Available: Y. Page Count: 1. Issue Publication Date: Oct, 2006.
AB - Reviews the book, In recovery: The making of mental health policy by Nora Jacobson (see record [rid]2004-21913-000[/rid]). Although the goals of the report are noble and worthy of aggressive pursuit, I have come to understand that transformation is supposed to create something new, both within the states and across the nation. As a result of her systematic observations, the author has written a textbook that reads like a novel and provides an in-depth understanding of the history of recovery concepts, along with detailed descriptions of how such concepts can be implemented meaningfully across mental health systems. This book is a must-read for all students of and participants in the transformation of mental health systems in the 21st century. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recovery
KW - mental health policy
KW - mental health systems
KW - 2006
KW - Mental Health Services
KW - Recovery (Disorders)
KW - Health Care Policy
KW - 2006
U2 - Jacobson, Nora. (2004); In recovery: The making of mental health policy; Nashville, Tennessee, Vanderbilt University Press, 208 pages, $24.95 softcover
DO - 10.1176/appi.ps.57.10.1530
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07321-038&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Martinez, M. N.
T1 - RT07 Understanding advantages and limitations of pre-clinical studies for dose selection.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/10/02/Oct2006 Supplement 1
VL - 29
IS - S1
M3 - Article
SP - 18
EP - 19
PB - Wiley-Blackwell
SN - 01407783
AB - Objective There are several means whereby dosage schedules for clinical use may be set, some more appropriate and scientific than others! The challenge of the 21st century must be for colleagues in the pharmaceutical industry, those serving registration bodies and academic colleagues to pool their expertise with the objective of designing dosage schedules for clinical use, which are based on the application of sound scientific principles appropriate for each drug class. In this Roundtable Session colleagues of international standing will review (a) pharmacological and other sources of variability in the responses to drugs; (b) the advantages and limitations of pre-clinical studies for dose selection; (c) the roles of population PK and population PK/PD together with Monte Carlo simulations in dosage regimen selection; (d) Bayesian approaches to dosage selection and (e) regulatory guidelines on the type and extent of studies required for selecting dosages. There is no unanimity amongst stakeholders on either the principles or the methods underlying dosage schedule design. Dose titration studies have long been the principal means of fixing doses but PK-PD and population PK-PD studies are now challenging more traditional approaches. The papers and discussion in this Roundtable Session will provide a critical basis for future advances in this crucial area of therapeutic drug usage. Getting the doses right means that the patient will receive maximum benefit, in terms of optimal efficacy with minimal toxicity, and hence correct dosing will contribute enormously to animal welfare. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL species
KW - DOSAGE forms of drugs
KW - VETERINARY medicine
KW - DRUGS -- Physiological effect
KW - ANTI-infective agents
KW - INFECTION
N1 - Accession Number: 22476299; Martinez, M. N. 1; Affiliation: 1: Office of New Animal Drug Evaluation, Centre for Veterinary Medicine, Food and Drug Administration, Rockville, Maryland, USA.; Source Info: Oct2006 Supplement 1, Vol. 29 Issue S1, p18; Subject Term: ANIMAL species; Subject Term: DOSAGE forms of drugs; Subject Term: VETERINARY medicine; Subject Term: DRUGS -- Physiological effect; Subject Term: ANTI-infective agents; Subject Term: INFECTION; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00772_2.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22476299&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martinez, M. N.
T1 - WS05 Regulatory efforts to minimize the selection of resistant bacteria.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/10/02/Oct2006 Supplement 1
VL - 29
IS - S1
M3 - Article
SP - 29
EP - 29
PB - Wiley-Blackwell
SN - 01407783
AB - Objective Antimicrobial resistance is not only here, it is here to stay and it poses major threats to the effective use of antimicrobial drugs in humans and other animals. Nevertheless, a defeatist attitude is not acceptable. There is much that can and must be done to retard or prevent the emergence and spread of resistance. Clinicians and scientists from many disciplines have roles to play in combating resistance and we veterinary pharmacologists arguably have the most important role of all. As Schentag (1996) indicated 10 years ago, ‘‘The design of appropriate dosage regimens may be the single most important contribution of clinical pharmacology to the resistance problem’’. However, progress has not been rapid and as recently as 2003 Drusano commented, ‘‘One area in which there is little investigation is the use of proper dosing to help prevent emergence of resistance’’ and, again in 2005, Drusano et al. commented ‘‘little attention has been focussed on delineating the correct dose to suppress the amplification of less susceptible mutant bacterial sub-populations’’. In this Workshop we address, with the help of internationally recognised authorities, antimicrobial resistance in veterinary medicine, from the perspectives of basic mechanisms, epidemiology and pre-clinical and population PK-PD modelling in dosage design. In addition, we review prudent use, clinical aspects and the contribution of regulatory efforts to minimise the selection of resistant microorganisms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - DRUG resistance
KW - DOSAGE of drugs
KW - MEDICAL education
KW - CONSUMERS
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 22476291; Martinez, M. N. 1; Affiliation: 1: US Food and Drug Administration, Centre for Veterinary Medicine (CVM), Office of New Animal Drug Evaluation, Rockville, Maryland 20855, USA.; Source Info: Oct2006 Supplement 1, Vol. 29 Issue S1, p29; Subject Term: ANTI-infective agents; Subject Term: DRUG resistance; Subject Term: DOSAGE of drugs; Subject Term: MEDICAL education; Subject Term: CONSUMERS; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00773_5.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22476291&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sundlof, S.
T1 - KN19 Veterinary drug availability: the American perspective.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/10/02/Oct2006 Supplement 1
VL - 29
IS - S1
M3 - Article
SP - 305
EP - 305
PB - Wiley-Blackwell
SN - 01407783
AB - The article focuses on an effort made by the U.S. Food and Drug Administration's Centre for Veterinary Medicine to balance high standards for the safety of veterinary drugs. The marketing of safe and effective animal drugs based on bioequivalence was allowed under the U.S. Generic Animal Drug and Patent Term Restoration Act. The law was designed to mount the quantity of drugs available to veterinarians and lessen the cost of individual drugs.
KW - VETERINARY drugs
KW - ANIMAL health
KW - VETERINARY drugs -- Law & legislation
KW - VETERINARY medicine
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 22476319; Sundlof, S. 1; Affiliation: 1: US Food and Drug Administration, Centre for Veterinary Medicine, Rockville, Maryland, USA.; Source Info: Oct2006 Supplement 1, Vol. 29 Issue S1, p305; Subject Term: VETERINARY drugs; Subject Term: ANIMAL health; Subject Term: VETERINARY drugs -- Law & legislation; Subject Term: VETERINARY medicine; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00768_2.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22476319&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vanderwagen, William
T1 - Health Diplomacy: Winning Hearts and Minds through the Use of Health Interventions.
JO - Military Medicine
JF - Military Medicine
Y1 - 2006/10/02/Oct2006 Supplement
VL - 171
M3 - Article
SP - 3
EP - 4
PB - AMSUS
SN - 00264075
AB - The article explores the concept of health diplomacy. Response to disasters, whether natural or manmade, must move quickly beyond emergency relief to creating capacity-building and recovery. Apart from safety and security, the next priority of should focus on the preservation of the health and the well-being of the people. This could be done through the establishment of empowered health institutions capable of implementing health interventions that will improve public health.
KW - PUBLIC health
KW - HEALTH
KW - HUMAN services
KW - DISASTER relief
KW - DISASTERS
N1 - Accession Number: 22828535; Vanderwagen, William 1; Affiliation: 1: U.S. Public Health Service, Rockville, MD 20852; Source Info: Oct2006 Supplement, Vol. 171, p3; Subject Term: PUBLIC health; Subject Term: HEALTH; Subject Term: HUMAN services; Subject Term: DISASTER relief; Subject Term: DISASTERS; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22828535&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reissman, Dori B.
AU - Schreiber, Merritt
AU - Klomp, Richard W.
AU - Hoover, Michele
AU - Kowalski-Trakofler, Kathleen
AU - Perez, Jon
T1 - The Virtual Network Supporting the Front Lines: Addressing Emerging Behavioral Health Problems following the Tsunami of 2004.
JO - Military Medicine
JF - Military Medicine
Y1 - 2006/10/02/Oct2006 Supplement
VL - 171
M3 - Article
SP - 40
EP - 43
PB - AMSUS
SN - 00264075
AB - The devastation wreaked by the 2004 tsunami in the Indian Ocean required extensive multinational and nongovernmental relief efforts to address the massive loss of infrastructure, people, and society. This article addresses approaches to behavioral incident management from a process perspective, through the lens of one official stateside channel of emergency operations. The process highlights the formation and connectivity of multidisciplinary teams that virtually supported the efforts of a seven-person, on-scene, behavioral health team aboard the USNS Mercy as part of Operation Unified Assistance in the Indian Ocean. Frontline health diplomacy and behavioral health relief efforts were greatly augmented by the virtual network of support from leading experts around the globe. Future disaster response and recovery efforts ought to build on the success of such virtual support networks, by planning for appropriate technology, expertise, and mutual aid partnerships. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BEHAVIOR disorders
KW - VIRTUAL networks
KW - DISASTER relief
KW - EMERGENCY management
KW - INDIAN Ocean Tsunami, 2004
N1 - Accession Number: 22828546; Reissman, Dori B. 1 Schreiber, Merritt 2 Klomp, Richard W. 1 Hoover, Michele 1 Kowalski-Trakofler, Kathleen 3 Perez, Jon 4; Affiliation: 1: Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341 2: National Center for Child Traumatic Stress, Neuropsychiatric Institute and Hospital, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 3: Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health, Pittsburgh, PA 15236 4: Behavioral Health Services, Indian Health Service, Rockville, MD 20852; Source Info: Oct2006 Supplement, Vol. 171, p40; Subject Term: BEHAVIOR disorders; Subject Term: VIRTUAL networks; Subject Term: DISASTER relief; Subject Term: EMERGENCY management; Subject Term: INDIAN Ocean Tsunami, 2004; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 913190 Other municipal protective services; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perez, Jon T.
AU - Coady, Jeffrey
AU - De Jesus, Elisa L.
AU - McGuinness, Kevin M.
AU - Bondan, Stanislaus
T1 - Operation Unified Assistance Population-Based Programs of the U.S. Public Health Service and International Team.
JO - Military Medicine
JF - Military Medicine
Y1 - 2006/10/02/Oct2006 Supplement
VL - 171
M3 - Article
SP - 53
EP - 58
PB - AMSUS
SN - 00264075
AB - The United States Public Health Service and several international relief agencies collaborated to create a series of programs for educational, governmental, and other behavioral health personnel in Aceh Province, Indonesia, following the tsunami of December 2004. This article provides a detailed account of the methodologies and approaches used to create the collaborations, as well as how they continue to be used by the people of Aceh through to this writing. Now known as the "Mercy Model," the approach represents a valuable set of programmatic approaches for rapidly developing and delivering large-scale behavioral health interventions in highly chaotic relief environments. It also details the potential benefits of using small teams on the ground, backed by much larger virtual teams to develop programming in real time across nations and continents, and do so in very short time frames. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERNATIONAL relief
KW - HUMANITARIAN assistance
KW - INTERNATIONAL agencies
KW - INDIAN Ocean Tsunami, 2004
KW - BANDA Aceh (Indonesia)
KW - INDONESIA
KW - UNITED States. Public Health Service
N1 - Accession Number: 22828549; Perez, Jon T. 1,2 Coady, Jeffrey 1,3 De Jesus, Elisa L. 4 McGuinness, Kevin M. 3 Bondan, Stanislaus 5; Affiliation: 1: USPHS 2: Division of Behavioral Health, Indian Health Service, Rockville, MD 20852 3: National Health Service Corps, Health Resources and Services Administration, Rockville, MD 20852 4: Australian Agency for International Development/Kanaivasu Foundation, Bali, Indonesia 5: Kanaivasu Foundation, Bali, Indonesia; Source Info: Oct2006 Supplement, Vol. 171, p53; Subject Term: INTERNATIONAL relief; Subject Term: HUMANITARIAN assistance; Subject Term: INTERNATIONAL agencies; Subject Term: INDIAN Ocean Tsunami, 2004; Subject Term: BANDA Aceh (Indonesia); Subject Term: INDONESIA; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 911410 Foreign affairs; NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Benedek, David M.
AU - Ritchie, Elspeth Cameron
T1 - "Just-in-Time" Mental Health Training and Surveillance for the Project HOPE Mission.
JO - Military Medicine
JF - Military Medicine
Y1 - 2006/10/02/Oct2006 Supplement
VL - 171
M3 - Article
SP - 63
EP - 65
PB - AMSUS
SN - 00264075
AB - Background: Immediately before the first sailing of the USS Mercy/Project HOPE relief mission to Southeast Asia, the mission leadership initiated presailing orientation and training and a program of survey-based health surveillance for mission participants. The training and surveillance efforts included a focus on mental health aspects of the mission. Methods: At the conclusion of the predeployment mental health training, a voluntary, anonymous, predeployment survey was administered to members of the Project HOPE team. A second survey was administered ∼3 months after return from the mission. The surveys were also administered before and after the second sailing of the USS Mercy/Project HOPE mission, although the training was not repeated. Results: The sample size prevented statistical analysis of predeployment and postdeployment rates of illness; however, there was no evidence of incidence beyond population baseline rates. Responses to questions regarding perceptions of mission success and personal achievement were quite favorable, whereas specific questions regarding shipboard resources, training, and professional interactions were met with more variable responses. Conclusions: Response rates suggest a strong interest among participants in efforts to address the Project HOPE program and resources. They also suggest resilience among participants and areas for improvement in communication among participants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MISSIONARY medicine
KW - MENTAL health
KW - TRAINING
KW - SOUTHEAST Asia
KW - PROJECT HOPE (Organization)
N1 - Accession Number: 22828551; Benedek, David M. 1 Ritchie, Elspeth Cameron 2; Affiliation: 1: Department of Psychiatry, Uniformed Services University School of Medicine, Bethesda, MD 20814 2: Office of the Surgeon General, Falls Church, VA 22041; Source Info: Oct2006 Supplement, Vol. 171, p63; Subject Term: MISSIONARY medicine; Subject Term: MENTAL health; Subject Term: TRAINING; Subject Term: SOUTHEAST Asia; Company/Entity: PROJECT HOPE (Organization); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106108244
T1 - Health diplomacy: winning hearts and minds through the use of health interventions.
AU - Vanderwagen W
Y1 - 2006/10/02/Oct2006 Supplement
N1 - Accession Number: 106108244. Language: English. Entry Date: 20070622. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Supplement Title: Oct2006 Supplement. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2984771R.
KW - Health Resource Allocation
KW - Humanitarian Aid
KW - Military Medicine
KW - Natural Disasters -- Indonesia
KW - Indonesia
SP - 3
EP - 4
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 171
CY - Bethesda, Maryland
PB - AMSUS
SN - 0026-4075
AD - U.S. Public Health Service, Rockville, MD 20852
U2 - PMID: 17447611.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106108259
T1 - Operation Unified Assistance population-based programs of the U.S. Public Health Service and international team.
AU - Perez JT
AU - Coady J
AU - De Jesus EL
AU - McGuinness KM
AU - Bondan S
Y1 - 2006/10/02/Oct2006 Supplement
N1 - Accession Number: 106108259. Language: English. Entry Date: 20070622. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Supplement Title: Oct2006 Supplement. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 2984771R.
KW - Community Mental Health Services
KW - Consumer Participation
KW - Humanitarian Aid -- Standards
KW - Multidisciplinary Care Team
KW - Natural Disasters -- Indonesia
KW - Psychiatry
KW - United States Public Health Service
KW - Volunteer Workers -- Psychosocial Factors
KW - Altruism
KW - Cultural Diversity
KW - Government
KW - Hospital Ships
KW - Indonesia
KW - Organizational Objectives
KW - United States
SP - 53
EP - 58
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 171
CY - Bethesda, Maryland
PB - AMSUS
AB - The United States Public Health Service and several international relief agencies collaborated to create a series of programs for educational, governmental, and other behavioral health personnel in Aceh Province, Indonesia, following the tsunami of December 2004. This article provides a detailed account of the methodologies and approaches used to create the collaborations, as well as how they continue to be used by the people of Aceh through to this writing. Now known as the 'Mercy Model,' the approach represents a valuable set of programmatic approaches for rapidly developing and delivering large-scale behavioral health interventions in highly chaotic relief environments. It also details the potential benefits of using small teams on the ground, backed by much larger virtual teams to develop programming in real time across nations and continents, and do so in very short time frames.
SN - 0026-4075
AD - Division of Behavioral Health, Indian Health Service, Rockville, MD 20852
U2 - PMID: 17447625.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shi, Leming
AU - Reid, Laura H.
AU - Jones, Wendell D.
AU - Shippy, Richard
AU - Warrington, Janet A.
AU - Baker, Shawn C.
AU - Collins, Patrick J.
AU - de Longueville, Francoise
AU - Kawasaki, Ernest S.
AU - Kathleen Y.Lee
AU - Yuling Luo
AU - Sun, Yongming Andrew
AU - Willey, James C.
AU - Setterquist, Robert A.
AU - Fischer, Gavin M.
AU - Tong, Weida
AU - Dragan, Yvonne P.
AU - Dix, David J.
AU - Frueh, Felix W.
AU - Goodsaid, Federico M.
T1 - The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/10/02/Oct2006 Supplement
VL - 24
M3 - Article
SP - 1151
EP - 1161
SN - 10870156
AB - Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Data analysis
KW - Experimental design
KW - Gene expression
KW - Genetic regulation
KW - DNA microarrays
KW - Molecular genetics
N1 - Accession Number: 22663242; Shi, Leming 1; Email Address: leming.shi@fda.hhs.gov; Reid, Laura H. 2; Jones, Wendell D. 2; Shippy, Richard 3; Warrington, Janet A. 4; Baker, Shawn C. 5; Collins, Patrick J. 6; de Longueville, Francoise 7; Kawasaki, Ernest S. 8; Kathleen Y.Lee 9; Yuling Luo 10; Sun, Yongming Andrew 9; Willey, James C. 11; Setterquist, Robert A. 12; Fischer, Gavin M. 13; Tong, Weida 1; Dragan, Yvonne P. 1; Dix, David J. 14; Frueh, Felix W. 15; Goodsaid, Federico M. 15; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.; 2: Expression Analysis, Inc., 2605 Meridian Parkway, Durham, North Carolina 27713, USA.; 3: GE Healthcare, 7700 S. River Parkway, Suite 2603, Tempe, AZ 85284, USA.; 4: Affymetrix, Inc., 3420 Central Expressway, Santa Clara, California 95051, USA.; 5: Illumina,Inc. 9885 Towne Centre Drive, San Diego, California 92121, USA.; 6: Agilent Technologies, Inc., 5301 Stevens Creek Blvd., Santa Clara, California 95051, USA.; 7: Eppendorf Array Technologies, rue du Séminaire 20a, 5000 Namur, Belgium.; 8: NCI Advanced Technology Center, 8717 Grovemont Circle, Bethesda, Maryland 20892, USA.; 9: Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.; 10: Panomics, Inc., 6519 Dumbarton Circle, Fremont, California 94555, USA.; 11: Medical University of Ohio, 3000 Arlington Avenue, Toledo, Ohio 43614, USA.; 12: Ambion, An Applied Biosystems Business, 2130 Woodward Street, Austin, Texas 78744, USA.; 13: Stratagene Corp., 11011 North Torrey Pines Road, La Jolla, California 92130, USA.; 14: Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, North Carolina 27711, USA.; 15: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA.; Issue Info: Oct2006 Supplement, Vol. 24, p1151; Thesaurus Term: RNA; Thesaurus Term: Data analysis; Thesaurus Term: Experimental design; Subject Term: Gene expression; Subject Term: Genetic regulation; Subject Term: DNA microarrays; Subject Term: Molecular genetics; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1038/nbt1239
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lei Guo
AU - Lobenhofer, Edward K.
AU - Wang, Charles
AU - Shippy, Richard
AU - Harris, Stephen C.
AU - Lu Zhang
AU - Nan Mei
AU - Tao Chen
AU - Herman, Damir
AU - Goodsaid, Federico M.
AU - Hurban, Patrick
AU - Phillips, Kenneth L.
AU - Jun Xu
AU - Xutao Deng
AU - Sun, Yongming Andrew
AU - Weida Tong
AU - Yvonne P.Dragan
AU - Leming Shi
T1 - Rat toxicogenomic study reveals analytical consistency across microarray platforms.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/10/02/Oct2006 Supplement
VL - 24
M3 - Article
SP - 1162
EP - 1169
SN - 10870156
AB - To validate and extend the findings of the MicroArray Quality Control (MAQC) project, a biologically relevant toxicogenomics data set was generated using 36 RNA samples from rats treated with three chemicals (aristolochic acid, riddelliine and comfrey) and each sample was hybridized to four microarray platforms. The MAQC project assessed concordance in intersite and cross-platform comparisons and the impact of gene selection methods on the reproducibility of profiling data in terms of differentially expressed genes using distinct reference RNA samples. The real-world toxicogenomic data set reported here showed high concordance in intersite and cross-platform comparisons. Further, gene lists generated by fold-change ranking were more reproducible than those obtained by t-test P value or Significance Analysis of Microarrays. Finally, gene lists generated by fold-change ranking with a nonstringent P-value cutoff showed increased consistency in Gene Ontology terms and pathways, and hence the biological impact of chemical exposure could be reliably deduced from all platforms analyzed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - Genetic toxicology
KW - Rats
KW - DNA microarrays
KW - Molecular genetics
KW - Gene expression
N1 - Accession Number: 22663243; Lei Guo 1; Lobenhofer, Edward K. 2; Wang, Charles 3; Shippy, Richard 4; Harris, Stephen C. 1; Lu Zhang 5; Nan Mei 1; Tao Chen 1; Herman, Damir 6; Goodsaid, Federico M. 7; Hurban, Patrick 2; Phillips, Kenneth L. 2; Jun Xu 3; Xutao Deng 3; Sun, Yongming Andrew 8; Weida Tong 1; Yvonne P.Dragan 1; Leming Shi 1; Email Address: leming.shi@fda.hhs.gov; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA; 2: Cogenics, A Division of Clinical Data, 100 Perimeter Park Drive, Suite C, Morrisville, North Carolina 27560, USA; 3: UCLA David Geffen School of Medicine, Transcriptional Genomics Core, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA; 4: GE Healthcare, 7700 S. River Parkway, Suite #2603, Tempe, Arizona 85284, USA; 5: Solexa, 25861 Industrial Boulevard, Hayward, California 94545, USA; 6: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, Maryland 20894, USA; 7: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA; 8: Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA; Issue Info: Oct2006 Supplement, Vol. 24, p1162; Thesaurus Term: RNA; Thesaurus Term: Genetic toxicology; Subject Term: Rats; Subject Term: DNA microarrays; Subject Term: Molecular genetics; Subject Term: Gene expression; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1038/nbt1238
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Graham, David J.
T1 - COX-2 Inhibitors, Other NSAIDs, and Cardiovascular Risk.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/10/04/
VL - 296
IS - 13
M3 - Article
SP - 1653
EP - 1656
SN - 00987484
AB - The article discusses how doctors and the U. S. Food and Drug Administration were led to approve nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors in spite of evidence that they caused cardiovascular side-effects. Soon after its release, studies showed that rofecoxib reduced serious gastrointestinal outcomes by 50% but caused thromboembolic cardiovascular evens to increase five times. The company did nothing to make these results known. Celecoxib also increases risk. The article accuses the medical community of "willfully accepting misdirection and disinformation" and calls on it to be more vigilant in the future.
KW - CARDIOVASCULAR diseases -- Risk factors
KW - PHARMACEUTICAL industry
KW - NONSTEROIDAL anti-inflammatory agents
KW - CYCLOOXYGENASE 2 -- Inhibitors
KW - ROFECOXIB
KW - CELECOXIB
KW - CORRUPT practices
KW - THERAPEUTIC use
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 22560641; Graham, David J. 1; Email Address: david.graham1@fda.hhs.gov; Affiliation: 1: US Food and Drug Administration; Source Info: 10/4/2006, Vol. 296 Issue 13, p1653; Subject Term: CARDIOVASCULAR diseases -- Risk factors; Subject Term: PHARMACEUTICAL industry; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: CYCLOOXYGENASE 2 -- Inhibitors; Subject Term: ROFECOXIB; Subject Term: CELECOXIB; Subject Term: CORRUPT practices; Subject Term: THERAPEUTIC use; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 106211914
T1 - COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense.
AU - Graham DJ
AU - Graham, David J
Y1 - 2006/10/04/
N1 - Accession Number: 106211914. Language: English. Entry Date: 20070112. Revision Date: 20161112. Publication Type: commentary; commentary; editorial. Original Study: Zhang J, Ding EL, Song Y, Zhang Jingjing, Ding Eric L, Song Yiqing. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. (JAMA) 10/4/2006; 296 (13): 1619-1632; McGettigan P, Henry D, McGettigan Patricia, Henry David. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. (JAMA) 10/4/2006; 296 (13): 1633-1667. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Antiinflammatory Agents, Non-Steroidal -- Adverse Effects
KW - Cardiovascular Diseases -- Chemically Induced
KW - Cox-2 Inhibitors -- Adverse Effects
KW - Clinical Trials
KW - Patient Safety
KW - Pharmaceutical Companies -- Economics
KW - United States Food and Drug Administration
SP - 1653
EP - 1656
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 296
IS - 13
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of Surveillance and Epidemiology, Food and Drug Administration, 10903 New Hampshire Ave, WO22, Room 4314, Silver Spring, MD 20993; david.graham1@fda.hhs.gov
U2 - PMID: 16968830.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Deng, Yang-mei
AU - Xie, Qiang-min
AU - Tang, Hui-fang
AU - Sun, Jian-gang
AU - Deng, Jun-fang
AU - Chen, Ji-qiang
AU - Yang, Shui-you
T1 - Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2006/10/10/
VL - 547
IS - 1-3
M3 - Article
SP - 125
EP - 135
SN - 00142999
AB - Abstract: PDE4 (phosphodiesterase-4) plays a critical role in pathogenesis of allergic asthma and chronic obstructive pulmonary disease (COPD). PDE4 inhibitors are presently under clinical development for the treatment of asthma and/or COPD. Ciclamilast, a new PDE4 inhibitor, is a piclamilast (RP 73401) structural analogue, but has a more potent inhibitory effect on PDE4 and inflammation in the airway tissues and less side effects than that of piclamilast. In this study, we elucidate primarily on the roles of compound on PDE4 enzyme in physiological and pathological processes in a mouse model of asthma. The sensitized/challenged mice were reexposed to ovalbumin and airway response to inhaled methacholine was monitored. Orally administration of ciclamilast, in a dose-dependent manner, significantly inhibited changes in lung resistance and lung dynamic compliance, as well as upregulation of cAMP-PDE activity, increase of PDE4D mRNA expression, but not PDE4B from lung tissue in the murine model. In addition, the compound dose-dependently reduced mRNA expression of eotaxin, tumor necrosis factor (TNF)-α and interleukin (IL)-4, but slightly increased mRNA expression of interferon (IFN)-γ from lung tissue. Further, levels of eotaxin, TNF-α and IL-4, and eosinophil and neutrophil accumulation in bronchoalveolar lavage fluid were also significantly reduced. Pathological examination, goblet cell hyperplasia and inflammatory cells infiltration in lung tissue were suppressed by treatment with ciclamilast. A significant correlation was observed between the increases in PDE4D mRNA expression and airway hyperresponsiveness. These studies confirm that inhibitory effect of ciclamilast on airway hyperresponsiveness includes its inhibiting PDE4D mRNA expression, down-modulating PDE4 activity, anti-inflammation and anti-mucus hypersecretion, and ciclamilast may have therapeutic potential for the treatment of asthma. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases
KW - LUNGS
KW - MESSENGER RNA
KW - RESPIRATORY allergy
KW - Airways hyperresponsiveness
KW - Asthma
KW - Ciclamilast
KW - Cytokines
KW - Dexamethasone
KW - Goblet cell
KW - Inflammation
KW - PDE4D
KW - Phosphodiesterase-4
N1 - Accession Number: 22395203; Deng, Yang-mei 1 Xie, Qiang-min; Email Address: xieqm@zju.edu.cn Tang, Hui-fang 1 Sun, Jian-gang 1 Deng, Jun-fang 1 Chen, Ji-qiang 1 Yang, Shui-you 1; Affiliation: 1: Zhejiang Respiratory Drugs Research Laboratory Of State Food And Drug Administration, Medical Science College Of Zhejiang University, Hangzhou, PR China; Source Info: Oct2006, Vol. 547 Issue 1-3, p125; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: LUNGS; Subject Term: MESSENGER RNA; Subject Term: RESPIRATORY allergy; Author-Supplied Keyword: Airways hyperresponsiveness; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Ciclamilast; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: Dexamethasone; Author-Supplied Keyword: Goblet cell; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: PDE4D; Author-Supplied Keyword: Phosphodiesterase-4; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ejphar.2006.07.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106221478
T1 - Putting prevention into practice. Screening for speech and language delay in preschool children.
AU - Mabry IR
Y1 - 2006/10/15/
N1 - Accession Number: 106221478. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; questions and answers. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Language Disorders -- In Infancy and Childhood
KW - Speech Disorders -- In Infancy and Childhood
KW - Child, Preschool
KW - Early Childhood Intervention
KW - Education, Continuing (Credit)
KW - Language Disorders -- Risk Factors
KW - Professional Practice, Evidence-Based
KW - Speech Disorders -- Risk Factors
SP - 1373
EP - 1434
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 74
IS - 8
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - US Preventive Services Task Force Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 17087432.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yeon-Joon Park
AU - Seungok Lee
AU - Jin Kyung Yu
AU - Gun-Jo Woo
AU - Kyungwon Lee
AU - Yoshichika Arakawa
T1 - Co-production of 16S rRNA methylases and extended-spectrum β-lactamases in AmpC-producing Enterobacter cloacae, Citrobacter freundii and Serratia marcescens in Korea.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2006/10/15/
VL - 58
IS - 4
M3 - Article
SP - 907
EP - 908
SN - 03057453
N1 - Accession Number: 22373877; Yeon-Joon Park 1; Seungok Lee 2; Jin Kyung Yu 3; Gun-Jo Woo 4; Kyungwon Lee 5; Yoshichika Arakawa 6; Affiliations: 1: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Korea; 2: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Holy Family Hospital 2 Sosa-dong, Wonmi-gu, Pucheon, Kyunggi-do, 420-717, Korea; 3: Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Korea; 4: Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-gu, Seoul 122-704, Korea; 5: Department of Laboratory Medicine, Yonsei University College of Medicine 134 Sinchon-dong, Seodaemun-ku, Seoul, 120-752, Korea; 6: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen Musashi-Murayama Tokyo 208-0011, Japan; Issue Info: Oct2006, Vol. 58 Issue 4, p907; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Budnitz, Daniel S.
AU - Pollock, Daniel A.
AU - Weidenbach, Kelly N.
AU - Mendelsohn, Aaron B.
AU - Schroeder, Thomas J.
AU - Annest, Joseph L.
T1 - National Surveillance of Emergency Department Visits for Outpatient Adverse Drug Events.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/10/18/
VL - 296
IS - 15
M3 - Article
SP - 1858
EP - 1866
SN - 00987484
AB - The article discusses outpatient use of drug therapies in the United States. While use of these therapies is beneficial, they also pose serious risks. Drug use is most likely to increase due to a rise of an aging population, new prescription medication development, and over-the counter drug availability. The article mentions a study where active surveillance is maintained for over a 2-year period that tracks the frequency of emergency room visits due to adverse drug effects in the United States. The study concluded that detrimental drug therapy is a crucial cause of mortality, especially those aged 65 years or older.
KW - THERAPEUTICS
KW - OLDER people
KW - DRUG utilization
KW - HOSPITAL emergency services
KW - MORTALITY
KW - MEDICATION errors
KW - SELF medication
KW - DRUGS
KW - UNITED States
N1 - Accession Number: 22757588; Budnitz, Daniel S. 1; Email Address: dbudnitz@cdc.gov Pollock, Daniel A. 1 Weidenbach, Kelly N. 1 Mendelsohn, Aaron B. 2,3,4 Schroeder, Thomas J. 5 Annest, Joseph L. 6; Affiliation: 1: Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Coordinating Center for Infectious Diseases 2: Office of Drug Safety, Centerfor Drug Evaluation and Research, US Food and Drug Administration, Rockville, Md 3: Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention 4: director of epidemiology, Product Safety, Medlmmune, Gaithersburg, Md. 5: US Consumer Product Safety Commission, Bethesda, Md 6: Office of Statistics and Programming, National Center for Injury Prevention and Control; Source Info: 10/18/2006, Vol. 296 Issue 15, p1858; Subject Term: THERAPEUTICS; Subject Term: OLDER people; Subject Term: DRUG utilization; Subject Term: HOSPITAL emergency services; Subject Term: MORTALITY; Subject Term: MEDICATION errors; Subject Term: SELF medication; Subject Term: DRUGS; Subject Term: UNITED States; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woo, E. J.
AU - Ball, R.
AU - Braun, M.
AU - Clark, T.
AU - Messonnier, N. Rosenstein
AU - Wharton, M.
AU - Vellozzi, C.
AU - Campbell, S.
AU - Weintraub, E.
AU - Davis, R.
T1 - Update: Guillain-Barré Syndrome Among Recipients of Menactra Meningococcal Conjugate Vaccine -- United States, June 2005-September 2006.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2006/10/20/
VL - 55
IS - 41
M3 - Article
SP - 1120
EP - 1154
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article presents an update on the possible association between Guillain-Barrae Syndrome (GBS) and receipt of meningococcal conjugate vaccine (MCV4). Eight confirmed cases of GBS within 6 weeks after MCV4 vaccination has been identified from March 2005 to February 2006. Nine additional GBS cases has been reported to the Vaccine Adverse Event Reporting System from March to September 2006.
KW - PHARMACOEPIDEMIOLOGY
KW - VACCINATION -- Complications
KW - DRUGS -- Side effects
KW - DRUGS -- Physiological effect
KW - NEISSERIA meningitidis
KW - GUILLAIN-Barre syndrome
N1 - Accession Number: 22828343; Woo, E. J. 1 Ball, R. 1 Braun, M. 1 Clark, T. Messonnier, N. Rosenstein Wharton, M. 2 Vellozzi, C. 3 Campbell, S. 3 Weintraub, E. 3 Davis, R. 3; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Admin, Rockville, Maryland 2: National Center for Immunization and Respiratory Diseases 3: Immunization Safety Office, Office of the Chief Science Officer, CDC; Source Info: 10/20/2006, Vol. 55 Issue 41, p1120; Subject Term: PHARMACOEPIDEMIOLOGY; Subject Term: VACCINATION -- Complications; Subject Term: DRUGS -- Side effects; Subject Term: DRUGS -- Physiological effect; Subject Term: NEISSERIA meningitidis; Subject Term: GUILLAIN-Barre syndrome; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Jian-gang
AU - Deng, Yang-mei
AU - Wu, Ximei
AU - Tang, Hui-fang
AU - Deng, Jun-fang
AU - Chen, Ji-qiang
AU - Yang, Shui-you
AU - Xie, Qiang-min
T1 - Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma
JO - Life Sciences
JF - Life Sciences
Y1 - 2006/10/26/
VL - 79
IS - 22
M3 - Article
SP - 2077
EP - 2085
SN - 00243205
AB - Abstract: Phosphodiesterase 4 (PDE4) isozyme plays important roles in inflammatory and immunomodulatory cells. In this study, piclamilast, a selective PDE4 inhibitor, was used to investigate the role of PDE4 in respiratory function and inflammation in a murine asthma model. Sensitized mice were challenged with aerosolized ovalbumin for 7 days, piclamilast (1, 3 and 10 mg/kg) and dexamethasone (2 mg/kg) were orally administered once daily during the period of challenge. Twenty-four hours after the last challenge, airway hyperresponsiveness to methacholine was determined by whole-body plethysmography, airway inflammation and mucus secretion by histomorphometry, pulmonary cAMP-PDE activity by HPLC, cytokine levels in bronchoalveolar lavage fluid and their mRNA expression in lung by ELISA and RT-PCR, respectively. In control mice, significant induction of cAMP-PDE activity was parallel to the increases of hyperresponsiveness, inflammatory cells, cytokine levels, mRNA expression as well as goblet cell hyperplasia. However, piclamilast dose-dependently and significantly improved airway resistance and dynamic compliance, and the maximal effect was similar to that of dexamethasone. Piclamilast treatment dose-dependently and significantly prevented the increase in inflammatory cell number and goblet cell hyperplasia, as well as production of cytokines, including eotaxin, TNFα and IL-4. Piclamilast exerted a weaker inhibitory effect than dexamethasone on eosinophils and neutrophils, had no effect on lymphocyte accumulation. Moreover, piclamilast inhibited up-regulation of cAMP-PDE activity and cytokine mRNA expression; the maximal inhibition of cAMP-PDE was greater than that exerted by dexamethasone, and was similar to dexamethasone on cytokine mRNA expression. This study suggests that inhibition of PDE4 by piclamilast robustly improves the pulmonary function, airway inflammation and goblet cell hyperplasia in murine allergenic asthma. [Copyright &y& Elsevier]
AB - Copyright of Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOENZYMES
KW - GLUCOCORTICOIDS
KW - ADRENOCORTICAL hormones
KW - ASTHMA
KW - Airway hyperresponsiveness
KW - Airway inflammation
KW - Asthma
KW - Phosphodiesterase 4
KW - Piclamilast
N1 - Accession Number: 22797822; Sun, Jian-gang 1 Deng, Yang-mei 1 Wu, Ximei 1 Tang, Hui-fang 1 Deng, Jun-fang 1 Chen, Ji-qiang 1 Yang, Shui-you 1 Xie, Qiang-min; Email Address: xieqm@zju.edu.cn; Affiliation: 1: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration, Medical Science College of Zhejiang University, Hangzhou 310031, PR China; Source Info: Oct2006, Vol. 79 Issue 22, p2077; Subject Term: ISOENZYMES; Subject Term: GLUCOCORTICOIDS; Subject Term: ADRENOCORTICAL hormones; Subject Term: ASTHMA; Author-Supplied Keyword: Airway hyperresponsiveness; Author-Supplied Keyword: Airway inflammation; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Phosphodiesterase 4; Author-Supplied Keyword: Piclamilast; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.lfs.2006.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung, Kyung-Sook
AU - Sun, Nam-Kyu
AU - Lee, Seung-Hee
AU - Lee, Hyun-Jee
AU - Choi, Shin-Jung
AU - Kim, Sun-Kyung
AU - Song, Ju-Hyun
AU - Jang, Young-Joo
AU - Song, Kyung-Bin
AU - Yoo, Hyang-Sook
AU - Simon, Julian
AU - Won, Misun
T1 - Cerulenin-mediated apoptosis is involved in adenine metabolic pathway
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2006/10/27/
VL - 349
IS - 3
M3 - Article
SP - 1025
EP - 1031
SN - 0006291X
AB - Abstract: Cerulenin, a fatty acid synthase (FAS) inhibitor, induces apoptosis of variety of tumor cells. To elucidate mode of action by cerulenin, we employed the proteomics approach using Schizosaccharomyces pombe. The differential protein expression profile of S. pombe revealed that cerulenin modulated the expressions of proteins involved in stresses and metabolism, including both ade10 and adk1 proteins. The nutrient supplementation assay demonstrated that cerulenin affected enzymatic steps transferring a phosphoribosyl group. This result suggests that cerulenin accumulates AMP and p-ribosyl-s-amino-imidazole carboxamide (AICAR) and reduces other necessary nucleotides, which induces feedback inhibition of enzymes and the transcriptional regulation of related genes in de novo and salvage adenine metabolic pathway. Furthermore, the deregulation of adenine nucleotide synthesis may interfere ribonucleotide reductase and cause defects in cell cycle progression and chromosome segregation. In conclusion, cerulenin induces apoptosis through deregulation of adenine nucleotide biosynthesis resulting in nuclear division defects in S. pombe. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CANCER cells
KW - CELLULAR pathology
KW - ADENINE nucleotides
KW - Ade10
KW - Adenine
KW - Adk1
KW - AICAR
KW - Cerulenin
KW - FAS
KW - Fas2/lsd1
KW - Fission yeast
N1 - Accession Number: 22592686; Chung, Kyung-Sook 1 Sun, Nam-Kyu 2,3 Lee, Seung-Hee 2,4 Lee, Hyun-Jee 1,2 Choi, Shin-Jung 1 Kim, Sun-Kyung 2 Song, Ju-Hyun 1,2 Jang, Young-Joo 5 Song, Kyung-Bin 2 Yoo, Hyang-Sook 1 Simon, Julian 4; Email Address: jsimon@fhcrc.org Won, Misun 1; Email Address: misun@kribb.re.kr; Affiliation: 1: Biopharmaceutical Division, KRIBB, 52 Oun-dong, Yusong-gu, Daejeon 305-806, Republic of Korea 2: Department of Food Science and Technology, Chungnam National University, Daejon, Republic of Korea 3: Food and Drug Administration, Gwangju Regional, Republic of Korea 4: Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA 5: The School of Dentistry, Dankook University, 29 Anseo-Dong, Cheonan 330-714, Republic of Korea; Source Info: Oct2006, Vol. 349 Issue 3, p1025; Subject Term: APOPTOSIS; Subject Term: CANCER cells; Subject Term: CELLULAR pathology; Subject Term: ADENINE nucleotides; Author-Supplied Keyword: Ade10; Author-Supplied Keyword: Adenine; Author-Supplied Keyword: Adk1; Author-Supplied Keyword: AICAR; Author-Supplied Keyword: Cerulenin; Author-Supplied Keyword: FAS; Author-Supplied Keyword: Fas2/lsd1; Author-Supplied Keyword: Fission yeast; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2006.08.130
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pacolay, Bruce D.
AU - Ham, Jason E.
AU - Wells, J.R.
T1 - Use of solid-phase microextraction to detect and quantify gas-phase dicarbonyls in indoor environments
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2006/10/27/
VL - 1131
IS - 1/2
M3 - Article
SP - 275
EP - 280
SN - 00219673
AB - Abstract: Solid-phase microextraction (SPME) was evaluated for the detection and quantification of the gas-phase dicarbonyls, glyoxal (GLY) and methylglyoxal (MGLY). Additionally, polydimethylsiloxane (PDMS), polydimethylsiloxane/divinylbenzene (PDMS/DVB), and carbowax/divinylbenzene (CW/DVB) fibers were tested to determine the optimum fiber for detection of these species. GLY and MGLY were derivatized with O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride (PFBHA), extracted with SPME from headspace or bag chamber and then analyzed by GC/MS. The PDMS/DVB SPME fiber for on-fiber derivatization and subsequent sampling for gas-phase methylglyoxal provided the optimum combination of analytical reproducibility and sensitivity. Linearity of the calibration curve was achieved across a range of 11–222μg/m3 (4–75ppb). [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Amines
KW - Organic compounds
KW - Chemical reactions
KW - Calibration
KW - Derivatization
KW - Dicarbonyls
KW - Glyoxal
KW - Methylglyoxal
KW - PFBHA
KW - Solid-phase microextraction
N1 - Accession Number: 22636152; Pacolay, Bruce D. 1; Ham, Jason E. 1; Wells, J.R.; Email Address: ozw0@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Oct2006, Vol. 1131 Issue 1/2, p275; Thesaurus Term: Amines; Thesaurus Term: Organic compounds; Subject Term: Chemical reactions; Subject Term: Calibration; Author-Supplied Keyword: Derivatization; Author-Supplied Keyword: Dicarbonyls; Author-Supplied Keyword: Glyoxal; Author-Supplied Keyword: Methylglyoxal; Author-Supplied Keyword: PFBHA; Author-Supplied Keyword: Solid-phase microextraction; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.chroma.2006.08.069
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - KLINMAN, DENNIS M.
AU - HANG XIE
AU - IVINS, BRUCE E.
T1 - CpG Oligonucleotides Improve the Protective Immune Response Induced by the Licensed Anthrax Vaccine.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2006/10/30/
VL - 1082
IS - 1
M3 - Article
SP - 137
EP - 150
SN - 00778923
AB - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTHRAX -- Vaccination
KW - BACTERIAL diseases
KW - IMMUNOLOGICAL adjuvants
KW - IMMUNE response
KW - ANTIGENS -- Analysis
KW - RHESUS monkey
KW - adjuvant
KW - anthrax
KW - CpG oligonucleotide
KW - protection
KW - vaccine
N1 - Accession Number: 24029166; KLINMAN, DENNIS M. 1; Email Address: Klinman@CBER.FDA.GOV HANG XIE 1 IVINS, BRUCE E. 2; Affiliation: 1: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA 2: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA; Source Info: 2006, Vol. 1082 Issue 1, p137; Subject Term: ANTHRAX -- Vaccination; Subject Term: BACTERIAL diseases; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: IMMUNE response; Subject Term: ANTIGENS -- Analysis; Subject Term: RHESUS monkey; Author-Supplied Keyword: adjuvant; Author-Supplied Keyword: anthrax; Author-Supplied Keyword: CpG oligonucleotide; Author-Supplied Keyword: protection; Author-Supplied Keyword: vaccine; Number of Pages: 14p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1196/annals.1348.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sercombe, Jason K.
AU - Eduard, Wijnand
AU - Romeo, Tony C.
AU - Green, Brett J.
AU - Tovey, Euan R.
T1 - Detection of allergens from Alternaria alternata by gold-conjugated anti-human IgE and field emission scanning electron microscopy
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2006/10/30/
VL - 316
IS - 1/2
M3 - Article
SP - 167
EP - 170
SN - 00221759
AB - Abstract: Fungal allergens are present in viable and non-viable conidia, hyphae and fungal fragments. It has been shown that large quantities of allergen are released from conidia during germination. We used a gold immunolabelling technique and field emission scanning electron microscopy to examine the allergen release from Alternaria alternata conidia. Immunolabelling was associated with the hyphal tip and amorphous matter associated with the emerging hyphae. Non-specific antibody controls showed no labelling associated with germinating fungi. This suggests that material released from hyphae may be an additional source of fungal allergens. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRON microscopy
KW - ANTIGENS
KW - BLOOD plasma
KW - BLOOD proteins
KW - 2% bovine serum albumin in phosphate-buffered saline with 0.05% Tween 20 ( BSA/PBS Tween: )
KW - Fungal allergens
KW - Gold immunolabelling
KW - halogen immunoassay ( HIA )
KW - mixed cellulose ester ( MCE )
KW - Scanning electron microscopy
KW - scanning electron microscopy ( SEM )
N1 - Accession Number: 22797753; Sercombe, Jason K. 1 Eduard, Wijnand 2; Email Address: wijnand.eduard@stami.no Romeo, Tony C. 3 Green, Brett J. 4 Tovey, Euan R. 1; Affiliation: 1: Woolcock Institute of Medical Research, Sydney, Australia, and The University of Sydney, Sydney, Australia 2: National Institute of Occupational Health, Oslo, Norway 3: Electron Microscope Unit, University of Sydney, Sydney, Australia 4: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA; Source Info: Oct2006, Vol. 316 Issue 1/2, p167; Subject Term: ELECTRON microscopy; Subject Term: ANTIGENS; Subject Term: BLOOD plasma; Subject Term: BLOOD proteins; Author-Supplied Keyword: 2% bovine serum albumin in phosphate-buffered saline with 0.05% Tween 20 ( BSA/PBS Tween: ); Author-Supplied Keyword: Fungal allergens; Author-Supplied Keyword: Gold immunolabelling; Author-Supplied Keyword: halogen immunoassay ( HIA ); Author-Supplied Keyword: mixed cellulose ester ( MCE ); Author-Supplied Keyword: Scanning electron microscopy; Author-Supplied Keyword: scanning electron microscopy ( SEM ); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jim.2006.08.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106120431
T1 - The science of surge: an all-hazard approach is critical to improving public health preparedness.
AU - Carmona RH
Y1 - 2006/11//
N1 - Accession Number: 106120431. Language: English. Entry Date: 20070720. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Disaster Planning
KW - Health Services Needs and Demand
KW - Public Health Administration
KW - California
KW - Congresses and Conferences
SP - 1097
EP - 1097
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 13
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1069-6563
AD - Surgeon General, U.S. Public Health Service, Rockville, MD, USA.
U2 - PMID: 16968686.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106120433
T1 - Current status of surge research...Academic Emergency Medicine Consensus Conference, 'Establishing the Science of Surge,' San Francisco, CA May 17, 2006
AU - Phillips S
Y1 - 2006/11//
N1 - Accession Number: 106120433. Language: English. Entry Date: 20070720. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Community Health Services
KW - Disaster Planning
KW - Emergency Medicine
KW - Emergency Service
KW - Health Services Research
KW - Benchmarking
KW - Biological Warfare
KW - Hospitals
KW - Immunization Programs
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - Volunteer Workers
SP - 1103
EP - 1108
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 13
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The dramatic escalation of bioterrorism and public health emergencies in the United States in recent years unfortunately has coincided with an equally dramatic decline in the institutions and services we rely on for emergency preparedness. Hospitals in nearly every metropolitan area in the country have closed; those that remain open have reduced the number of available beds. 'Just in time' supplies and health professional shortages have further compromised the nation's overall surge capacity. Emergency departments routinely operate at capacity. These circumstances make evidence-based research on emergency preparedness and surge capacity both more urgently needed and more complex. The Agency for Healthcare Research and Quality and other government and private agencies have been rapidly widening the field of knowledge in this area in recent months and years. This report focuses primarily on the work of the Agency for Healthcare Research and Quality.
SN - 1069-6563
AD - Agency for Healthcare Research and Quality, 540 Gaiter Road, Rockville, MD 20850, USA. sally.phillips@ahrq.hhs.gov
U2 - PMID: 17032944.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106120433&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106120438
T1 - Surge capacity for health care systems: early detection, methodologies, and process...Academic Emergency Medicine Consensus Conference, 'Establishing the Science of Surge,' San Francisco, CA May 17, 2006
AU - Estacio PL
Y1 - 2006/11//
N1 - Accession Number: 106120438. Language: English. Entry Date: 20070720. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9418450.
KW - Disaster Planning
KW - Disease Surveillance
KW - Emergency Medicine
KW - Emergency Service
KW - Diagnosis, Laboratory
KW - Information Systems
SP - 1135
EP - 1137
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
JA - ACAD EMERG MED
VL - 13
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Excessive demand on hospital services from large-scale emergencies is something that every emergency department health care provider and hospital administrator knows could happen at any time. Nowhere in this country have we recently faced a disaster of the magnitude of concern we now face involving agents of mass destruction or social disruption, especially those in the area of infectious diseases and radiological materials. The war on terrorism is not a conventional war, and terrorists may use any means of convenience to carry out their objectives in an unpredictable time line. Have we adequately prepared for the potentially excessive surge in demand for medical services that a large-scale event could bring to our medical care system? Are our emergency departments ready for such events? Surveillance systems, such as BioWatch, BioSense, the National Biosurveillance Integration System, and the countermeasure program BioShield, offer hope that we will be able to meet these new challenges.
SN - 1069-6563
AD - Department of Health and Human Services, Office of Public Health Emergency Preparedness, 100 Independence Avenue, 636G, Washington, DC 20201, USA. peter.estacio@hhs.gov
U2 - PMID: 17085739.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106120438&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goldkind, Sara F.
T1 - A Review of: “Book Reviews Eric Kodish, Ethics and Research with Children. New York, NY: Oxford University Press, 2005. 361 pp. $59.50, hardcover.”.
JO - American Journal of Bioethics
JF - American Journal of Bioethics
Y1 - 2006/11//
VL - 6
IS - 6
M3 - Book Review
SP - 71
EP - 72
PB - Routledge
SN - 15265161
AB - The article present a review of the book "Ethics and Research with Children," by Eric Kodish.
KW - BIOETHICS
KW - NONFICTION
KW - KODISH, Eric
KW - ETHICS & Research With Children: A Case-Based Approach (Book)
N1 - Accession Number: 22976722; Goldkind, Sara F. 1; Affiliation: 1: Food and Drug Administration; Source Info: Nov2006, Vol. 6 Issue 6, p71; Subject Term: BIOETHICS; Subject Term: NONFICTION; Reviews & Products: ETHICS & Research With Children: A Case-Based Approach (Book); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: KODISH, Eric; Number of Pages: 2p; Document Type: Book Review
L3 - 10.1080/15265160600939243
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22976722&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trumbo, Paula R.
AU - Ellwood, Kathleen C.
T1 - Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims.
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
Y1 - 2006/11//
VL - 84
IS - 5
M3 - Article
SP - 971
EP - 974
SN - 00029165
AB - The labeling of health claims that meet the significant scientific agreement standard and of qualified health claims on conventional foods and dietary supplements requires premarket approval by the Food and Drug Administration (FDA). The FDA conducts an evidence-based review to ascertain whether sufficient evidence exists to support a significant scientific agreement standard or a qualified health claim. The FDA recently reviewed intervention and observational studies that evaluated the role of lutein and zeaxanthin in reducing the risk of age-related macular degeneration and cataracts. On the basis of this evidence-based review, the FDA concluded that no credible evidence exists for a health claim about the intake of lutein or zeaxanthin (or both) and the risk of age-related macular degeneration or cataracts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - age-related macular degeneration
KW - cataracts
KW - health claims
KW - Lutein
KW - zeaxanthin
N1 - Accession Number: 94607082; Trumbo, Paula R. 1; Email Address: paula.trumbo@fda.gov; Ellwood, Kathleen C. 1; Affiliations: 1: Division of Nutrition Programs and Labeling, Food and Drug Administration, College Park, MD; Issue Info: Nov2006, Vol. 84 Issue 5, p971; Author-Supplied Keyword: age-related macular degeneration; Author-Supplied Keyword: cataracts; Author-Supplied Keyword: health claims; Author-Supplied Keyword: Lutein; Author-Supplied Keyword: zeaxanthin; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106223658
T1 - Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims.
AU - Trumbo PR
AU - Ellwood KC
Y1 - 2006/11//
N1 - Accession Number: 106223658. Language: English. Entry Date: 20070126. Revision Date: 20150819. Publication Type: Journal Article; review. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Cataract -- Prevention and Control -- In Old Age
KW - Consumer Health Information
KW - Diet -- In Old Age
KW - Food Labeling
KW - Lutein -- In Old Age
KW - Macular Degeneration -- Prevention and Control -- In Old Age
KW - Zeaxanthin -- In Old Age
KW - Aged
KW - United States
KW - United States Food and Drug Administration
SP - 971
EP - 974
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 84
IS - 5
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - The labeling of health claims that meet the significant scientific agreement standard and of qualified health claims on conventional foods and dietary supplements requires premarket approval by the Food and Drug Administration (FDA). The FDA conducts an evidence-based review to ascertain whether sufficient evidence exists to support a significant scientific agreement standard or a qualified health claim. The FDA recently reviewed intervention and observational studies that evaluated the role of lutein and zeaxanthin in reducing the risk of age-related macular degeneration and cataracts. On the basis of this evidence-based review, the FDA concluded that no credible evidence exists for a health claim about the intake of lutein or zeaxanthin (or both) and the risk of age-related macular degeneration or cataracts. Copyright © 2006 American Society for Nutrition
SN - 0002-9165
AD - Division of Nutrition Programs and Labeling, Food and Drug Administration, HFS-830, 5100 Paint Branch Parkway, College Park, MD 20740; paula.trumbo@fda.gov
U2 - PMID: 17093145.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106223658&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106139885
T1 - Peripheral insensate neuropathy -- a tall problem for US adults?
AU - Cheng YJ
AU - Gregg EW
AU - Kahn HS
AU - Williams DE
AU - De Rekeneire N
AU - Narayan KMV
Y1 - 2006/11//
N1 - Accession Number: 106139885. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 7910653.
KW - Body Height -- Physiology
KW - Diabetic Neuropathies -- Epidemiology
KW - Peripheral Nervous System Diseases -- Epidemiology
KW - Confidence Intervals
KW - Data Analysis Software
KW - Female
KW - Hemoglobin A, Glycosylated -- Analysis
KW - Linear Regression
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Odds Ratio
KW - Prevalence
KW - Relative Risk
KW - Sex Factors
KW - Surveys
KW - United States
KW - Human
SP - 873
EP - 880
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 164
IS - 9
PB - Oxford University Press / USA
AB - The relation between height and lower extremity peripheral insensate neuropathy among persons with and without diabetes was examined by use of the 1999-2002 US National Health and Nutrition Examination Survey with 5,229 subjects aged 40 or more years. A monofilament was used to determine whether any of three areas on each foot were insensate. Peripheral insensate neuropathy was defined as the presence of one or more insensate areas. Its prevalence was nearly twice as high among persons with diabetes (21.2%) as among those without diabetes (11.5%; p < 0.001). Men (16.2%) had 1.7 times the prevalence of peripheral insensate neuropathy as did women (9.4%), but the difference was not significant after adjustment for height. Greater height was associated with increased peripheral insensate neuropathy prevalence among persons with and without diabetes (p < 0.001). This association was characterized by a sharp increase in prevalence among persons who were taller than 175.5 cm. Peripheral insensate neuropathy risk was significantly higher among those taller than 175.5 cm (adjusted odds ratio = 2.3, 95% confidence interval: 1.5, 3.5). The authors conclude that body height is an important correlate of peripheral insensate neuropathy. This association largely accounts for the difference in peripheral insensate neuropathy prevalence between men and women. Height may help health-care providers to identify persons at high risk of peripheral insensate neuropathy.
SN - 0002-9262
AD - Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA
U2 - PMID: 16905646.
DO - aje/kwj281
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106139885&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106227460
T1 - Needlestick injury and accidental exposure to blood: the need for improving the hepatitis B vaccination grade among health care workers outside the hospital.
AU - Vos D
AU - Götz HM
AU - Richardus JH
Y1 - 2006/11//
N1 - Accession Number: 106227460. Language: English. Entry Date: 20070202. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Health Personnel
KW - Hepatitis B -- Prevention and Control
KW - Immunization
KW - Needlestick Injuries
KW - Occupational Exposure
KW - Health Facilities
KW - Needles
KW - Netherlands
KW - Human
SP - 610
EP - 612
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 34
IS - 9
CY - New York, New York
PB - Elsevier Science
AB - To describe the characteristics of needlestick injuries occurring to health care workers outside the hospital, a new case report form was implemented and analyzed after 12 months. A total of 144 incidents were reported. Of the needlestick injuries in nursing assistants, 84% involved an insulin needle or pen. Thirty-five percent of all health care workers and 47% of the nursing assistants were not vaccinated against hepatitis B. Hepatitis B vaccination grade in health care workers outside the hospital should be improved, in particular among nursing assistants.
SN - 0196-6553
AD - Division of Infectious Disease Control, Rotterdam Public Health Service, Rotterdam, The Netherlands. dieuwke.vos@rivm.nl
U2 - PMID: 17097460.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106227460&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106112129
T1 - Care transitions: a threat and an opportunity for patient safety.
AU - Clancy CM
Y1 - 2006/11//Nov/Dec2006
N1 - Accession Number: 106112129. Language: English. Entry Date: 20070629. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9300756.
KW - Continuity of Patient Care -- Administration
KW - Health Facility Administration
KW - Safety
KW - Transfer, Discharge -- Administration
KW - Multidisciplinary Care Team -- Administration
SP - 415
EP - 417
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 21
IS - 6
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 17077424.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106112129&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miller, Ran A.
AU - Reimschuessel, Renate
T1 - Epidemiologic cutoff values for antimicrobial agents against Aeromonas salmonicida isolates determined by frequency distributions of minimal inhibitory concentration and diameter of zone of inhibition data.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 2006/11//
VL - 67
IS - 11
M3 - Article
SP - 1837
EP - 1843
SN - 00029645
AB - Objective--To develop epidemiologic cutoff values by use of frequency distributions for susceptibility to 4 antimicrobial agents when tested against a representative population of a major aquaculture pathogen, Aeromonas salmonicida. Sample Population--217 typical and atypical A salmonicide isolates obtained from 20 states and 12 countries, Procedures--Species identification of A salmonicida isolates was confirmed by detection of specific nucleotide sequences by use of a PCR assay. Minimal inhibitory concentration (MIC) and diameter of the zone of inhibition for oxytetracycline, ormetoprim-sulfadimethoxine, oxolinic acid, and florfenicol were determined for each isolate in accordance with standardized antimicrobial susceptibility testing methods that have been approved by the Clinical and Laboratory Standards Institute for bacterial isolates from aquatic animals. Susceptibility data were tabulated in a scattergram and analyzed by use of error rate bounding. Results--Susceptibility tests for oxytetracycline, ormetoprim-sulfadimethoxine, and oxolinic acid revealed 2 distinct populations of bacteria. Isolates tested against florfenicol clustered into a single population. Oxolinic acid susceptibility data revealed higher MICs in the non-United States A salmonicida isolates. Slow-growing (atypical) A salmonicida isolates were generally more susceptible than typical isolates for all antimicrobials, except oxolinic acid. Conclusions and Clinical Relevance--Use of frequency distributions of susceptibility results to develop epidemiologic cutoff values appears to be applicable to aquatic isolates. Frequency distributions of susceptibility results for A salmonicida revealed clear divisions between isolate susceptibilities. This type of data, considered in conjunction with pharmacokinetic and efficacy data, may be useful for developing clinical breakpoints for use in aquaculture. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Veterinary Research is the property of American Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - DISTRIBUTION (Probability theory)
KW - ANTI-infective agents
KW - AEROMONAS salmonicida
KW - MICROBIAL sensitivity tests
KW - AQUACULTURE
N1 - Accession Number: 23042334; Miller, Ran A. 1 Reimschuessel, Renate 1; Affiliation: 1: FDA, Center for Veterinary Medicine, Office of Research, Division of Animal Research, 8401 Muirkirk Rd, Laurel, MD 20708; Source Info: Nov2006, Vol. 67 Issue 11, p1837; Subject Term: EPIDEMIOLOGY; Subject Term: DISTRIBUTION (Probability theory); Subject Term: ANTI-infective agents; Subject Term: AEROMONAS salmonicida; Subject Term: MICROBIAL sensitivity tests; Subject Term: AQUACULTURE; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 7p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106018357
T1 - Reports of death with use of Propofol (Diprivan) for nonprocedural (long-term) sedation and literature review.
AU - Wysowski DK
AU - Pollock ML
Y1 - 2006/11//2006 Nov
N1 - Accession Number: 106018357. Language: English. Entry Date: 20080104. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1300217.
KW - Hypnotics and Sedatives -- Adverse Effects
KW - Propofol -- Adverse Effects
KW - Acidosis -- Chemically Induced
KW - Adult
KW - Adverse Drug Event
KW - Cardiovascular System -- Drug Effects
KW - Child
KW - Drug Information Services
KW - Hypnotics and Sedatives -- Administration and Dosage
KW - Hypotension -- Chemically Induced
KW - Infusions, Intravenous
KW - Mortality
KW - Propofol -- Administration and Dosage
KW - Risk Factors
KW - Safety
KW - Syndrome
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 1047
EP - 1051
JO - Anesthesiology
JF - Anesthesiology
JA - ANESTHESIOLOGY
VL - 105
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0003-3022
AD - Food and Drug Administration, Division of Drug Risk Evaluation, HFD-430, White Oak Building 22, Room 3424, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993; dian.wysowski@fda.hhs.gov
U2 - PMID: 17065900.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Harbottle, H.
AU - Thakur, S.
AU - Zhao, S.
AU - White, D. G.
T1 - Genetics of Antimicrobial Resistance.
JO - Animal Biotechnology
JF - Animal Biotechnology
Y1 - 2006/11//
VL - 17
IS - 2
M3 - Article
SP - 111
EP - 124
PB - Taylor & Francis Ltd
SN - 10495398
AB - Antimicrobial resistant strains of bacteria are an increasing threat to animal and human health. Resistance mechanisms to circumvent the toxic action of antimicrobials have been identified and described for all known antimicrobials currently available for clinical use in human and veterinary medicine. Acquired bacterial antibiotic resistance can result from the mutation of normal cellular genes, the acquisition of foreign resistance genes, or a combination of these two mechanisms. The most common resistance mechanisms employed by bacteria include enzymatic degradation or alteration of the antimicrobial, mutation in the antimicrobial target site, decreased cell wall permeability to antimicrobials, and active efflux of the antimicrobial across the cell membrane. The spread of mobile genetic elements such as plasmids, transposons, and integrons has greatly contributed to the rapid dissemination of antimicrobial resistance among several bacterial genera of human and veterinary importance. Antimicrobial resistance genes have been shown to accumulate on mobile elements, leading to a situation where multidrug resistance phenotypes can be transferred to a susceptible recipient via a single genetic event. The increasing prevalence of antimicrobial resistant bacterial pathogens has severe implications for the future treatment and prevention of infectious diseases in both animals and humans. The versatility with which bacteria adapt to their environment and exchange DNA between different genera highlights the need to implement effective antimicrobial stewardship and infection control programs in both human and veterinary medicine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Animal Biotechnology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - GENETICS
KW - Bacterial genetics
KW - Pathogenic microorganisms
KW - Anti-infective agents in veterinary medicine
KW - Drug resistance
KW - Veterinary medicine
KW - Animal health
KW - Plasmids
KW - Livestock diseases
KW - Antimicrobial resistance genes
KW - Antimicrobial resistance mechanisms
KW - Conjugation
KW - Integron
KW - Plasmid
KW - Transposon
N1 - Accession Number: 23219994; Harbottle, H. 1; Email Address: heather.harbottle@fda.hhs.gov; Thakur, S. 1; Zhao, S. 1; White, D. G. 1; Affiliations: 1: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, USA.; Issue Info: Nov2006, Vol. 17 Issue 2, p111; Thesaurus Term: Mutation (Biology); Thesaurus Term: GENETICS; Thesaurus Term: Bacterial genetics; Thesaurus Term: Pathogenic microorganisms; Subject Term: Anti-infective agents in veterinary medicine; Subject Term: Drug resistance; Subject Term: Veterinary medicine; Subject Term: Animal health; Subject Term: Plasmids; Subject Term: Livestock diseases; Author-Supplied Keyword: Antimicrobial resistance genes; Author-Supplied Keyword: Antimicrobial resistance mechanisms; Author-Supplied Keyword: Conjugation; Author-Supplied Keyword: Integron; Author-Supplied Keyword: Plasmid; Author-Supplied Keyword: Transposon; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/10495390600957092
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106121971
T1 - A perioperative nurse serves a lifetime among Native Americans.
AU - Redford T
Y1 - 2006/11//2006 Nov
N1 - Accession Number: 106121971. Language: English. Entry Date: 20070720. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Nursing; USA.
KW - Health Services, Indigenous
KW - Native Americans -- Arizona
KW - Perioperative Nursing
KW - Arizona
KW - Culture
KW - Hospitals
KW - Maps
SP - 12
EP - 15
JO - AORN Connections
JF - AORN Connections
JA - AORN CONNECT
VL - 4
IS - 11
CY - Denver, Colorado
PB - Association of periOperative Registered Nurses
SN - 1545-374X
AD - Ambulatory Surgery/CSR Program Director, Whiteriver Indian Health Service, Whiteriver, AZ; Trudy.Redford@ihs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106235263
T1 - Ask an expert. Research priorities.
AU - Hughes RG
Y1 - 2006/11//
N1 - Accession Number: 106235263. Language: English. Entry Date: 20070216. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8901557.
KW - Research Priorities
KW - Research, Nursing
SP - 223
EP - 224
JO - Applied Nursing Research
JF - Applied Nursing Research
JA - APPL NURS RES
VL - 19
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0897-1897
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD 20852, USA.
U2 - PMID: 17098163.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106235263&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Baitty, Robert L.
AU - Tims, Shelley E.
AU - Wabeke, Anita
AU - Ashton, Robyn
AU - Gale, Randy
AU - Burdick, James F.
T1 - 23: Implementing the Stem Cell Therapeutic and Research Act of 2005
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2006/11//
VL - 12
IS - 11
M3 - Abstract
SP - 1226
EP - 1226
SN - 10838791
N1 - Accession Number: 22965778; Baitty, Robert L. 1 Tims, Shelley E. 1 Wabeke, Anita 1 Ashton, Robyn 1 Gale, Randy 1 Burdick, James F. 1; Affiliation: 1: Department of Health and Human Services, Health Resources and Services Administration, Division of Transplantation, Rockville, MD; Source Info: Nov2006, Vol. 12 Issue 11, p1226; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.bbmt.2006.08.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Potter, Christopher C.
AU - Harries, Jennifer
T1 - The determinants of policy effectiveness.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2006/11//
VL - 84
IS - 11
M3 - Article
SP - 843
EP - 843
PB - World Health Organization
SN - 00429686
AB - The article focuses on the article by S. Siddiqi, T. I. Masud and B. Sabri regarding the practical limitations of implementing strategy for health care sector reform. Siddiqi and colleagues states that contracting out requires tendering arrangements and the capacity to operate them. In addition, they illustrate the determinants of policy effectiveness and the limiting factors to successful enforcement of policy initiatives. In addition, Siddiqi and colleagues enumerates the issues that need to be considered for the implementation of the health care program such as the realities of public administration system and the local training of professionals.
KW - CONTRACTING out
KW - MEDICAL care -- Contracting out
KW - PUBLIC contracts
KW - HUMAN services -- Contracting out
KW - PUBLIC welfare -- Contracting out
KW - PUBLIC-private sector cooperation
KW - HEALTH services administration
KW - MEDICAL policy
KW - MEDICAL economics
N1 - Accession Number: 27721446; Potter, Christopher C. 1; Email Address: pottercc@cf.ac.uk Harries, Jennifer 2; Affiliation: 1: University of Cardiff, Department of Epidemiology, Statistics and Public Health, Cardiff, Wales 2: National Public Health Service for Wales, Cardiff, Wales; Source Info: Nov2006, Vol. 84 Issue 11, p843; Subject Term: CONTRACTING out; Subject Term: MEDICAL care -- Contracting out; Subject Term: PUBLIC contracts; Subject Term: HUMAN services -- Contracting out; Subject Term: PUBLIC welfare -- Contracting out; Subject Term: PUBLIC-private sector cooperation; Subject Term: HEALTH services administration; Subject Term: MEDICAL policy; Subject Term: MEDICAL economics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Connor, Thomas H.
AU - McDiarmid, Melissa A.
T1 - Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings.
JO - CA: A Cancer Journal for Clinicians
JF - CA: A Cancer Journal for Clinicians
Y1 - 2006/11//Nov/Dec2006
VL - 56
IS - 6
M3 - Article
SP - 354
EP - 365
SN - 00079235
AB - The article examines the ways of preventing occupational exposure to antineoplastic drugs in health care settings in the U.S. Government agencies released safety guidelines to protect healthcare workers from the drugs' harmful effects. The National Institute for Occupational Safety and Health promoted a program that urged safe handling of the medications during their use.
KW - ANTINEOPLASTIC agents
KW - INDUSTRIAL safety
KW - HEALTH facilities
KW - NATIONAL Institute for Occupational Safety & Health
KW - MEDICAL care
KW - UNITED States
N1 - Accession Number: 23496301; Connor, Thomas H. 1; McDiarmid, Melissa A. 2; Source Information: Nov/Dec2006, Vol. 56 Issue 6, p354; Subject: ANTINEOPLASTIC agents; Subject: INDUSTRIAL safety; Subject: HEALTH facilities; Subject: NATIONAL Institute for Occupational Safety & Health; Subject: MEDICAL care; Geographic Terms: UNITED States; Number of Pages: 12p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Chen, F.
AU - Bhatia, D.
AU - Chang, Q.
AU - Castranova, V.
T1 - Finding NEMO by K63-linked polyubiquitin chain.
JO - Cell Death & Differentiation
JF - Cell Death & Differentiation
Y1 - 2006/11//
VL - 13
IS - 11
M3 - Article
SP - 1835
EP - 1838
PB - Nature Publishing Group
SN - 13509047
AB - The article presents the evidence of NEMO, a regulatory subunit of IKK complex by K63-linked polyubiquitin chain. The discovery of NEMO binding to the K63-linked polyubiquitin chain leading to the activation of IKK and conjugation to RIP and TRAF proteins is presented. The article also presents the ubiquitination in NF-kB signaling.
KW - UBIQUITIN
KW - NF-kappa B (DNA-binding protein)
KW - CELLULAR signal transduction
KW - TRANSCRIPTION factors
KW - PHOSPHORYLATION
KW - PROTEIN kinases
KW - DNA damage
N1 - Accession Number: 22985834; Chen, F. 1,2,3; Email Address: lfd3@cdc.gov Bhatia, D. 1,2 Chang, Q. 4 Castranova, V. 1,2; Affiliation: 1: The Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA 2: Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA 3: Department of Pathology, West Virginia University, Morgantown, WV, USA 4: Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Source Info: Nov2006, Vol. 13 Issue 11, p1835; Subject Term: UBIQUITIN; Subject Term: NF-kappa B (DNA-binding protein); Subject Term: CELLULAR signal transduction; Subject Term: TRANSCRIPTION factors; Subject Term: PHOSPHORYLATION; Subject Term: PROTEIN kinases; Subject Term: DNA damage; Number of Pages: 4p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1038/sj.cdd.4402014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singleton, Rosalyn J.
AU - Holman, Robert C.
AU - Cobb, Nathaniel
AU - Curns, Aaron T.
AU - Paisano, Edna L.
T1 - Asthma Hospitalizations Among American Indian and Alaska Native People and for the General US Population.
JO - CHEST
JF - CHEST
Y1 - 2006/11//
VL - 130
IS - 5
M3 - Article
SP - 1554
EP - 1562
SN - 00123692
AB - The article examines the asthma hospitalization rates for the American Indian/Alaska Native (AI/AN) and for the general population of the U.S. It claims that a decrease in hospitalization rate has been observed among AI/AN populations from 17.8/10, 000 per year in 1988 to 1990 to 12.9/10, 000 per year in 2000 to 2002. It adds that rates for age groups older than one year were the same or lower compared to the U.S. population. It resolves that the average rate was lower for the AI/AN populations.
KW - HOSPITAL care
KW - ASTHMA
KW - LUNG diseases
KW - HOSPITAL respiratory services
KW - POPULATION
KW - NATIVE Americans
KW - UNITED States
KW - Alaskan Native
KW - American Indian
KW - asthma
KW - children
KW - epidemiology (pulmonary)
KW - hospitalization
KW - pulmonary
N1 - Accession Number: 23258794; Singleton, Rosalyn J. 1; Email Address: ris2@cdc.gov Holman, Robert C. 2 Cobb, Nathaniel 3 Curns, Aaron T. 2 Paisano, Edna L. 4; Affiliation: 1: Alaska Native Tribal Health Consortium, Anchorage, AK 2: Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 3: Chronic Disease Branch, Division of Epidemiology, Albuquerque NM 4: Division of Program Statistics, Office of Public Health Support, Indian Health Service, U.S. Department of Health and Human Services, Rockville, MD; Source Info: Nov2006, Vol. 130 Issue 5, p1554; Subject Term: HOSPITAL care; Subject Term: ASTHMA; Subject Term: LUNG diseases; Subject Term: HOSPITAL respiratory services; Subject Term: POPULATION; Subject Term: NATIVE Americans; Subject Term: UNITED States; Author-Supplied Keyword: Alaskan Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: asthma; Author-Supplied Keyword: children; Author-Supplied Keyword: epidemiology (pulmonary); Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: pulmonary; Number of Pages: 9p; Illustrations: 3 Charts, 3 Graphs, 1 Map; Document Type: Article
L3 - 10.1378/chest.130.5.1554
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takahashi, Masaya
AU - Nakata, Akinori
AU - Haratani, Takashi
AU - Otsuka, Yasumasa
AU - Kaida, Kosuke
AU - Fukasawa, Kenji
T1 - Psychosocial Work Characteristics Predicting Daytime Sleepiness in Day and Shift Workers.
JO - Chronobiology International: The Journal of Biological & Medical Rhythm Research
JF - Chronobiology International: The Journal of Biological & Medical Rhythm Research
Y1 - 2006/11//
VL - 23
IS - 6
M3 - Article
SP - 1409
EP - 1422
SN - 07420528
AB - Characteristics of work organization other than working time arrangements may contribute importantly to daytime sleepiness. The present study was designed to identify the psychosocial factors at work that predict daytime sleepiness in a sample of day and shift workers. Participants working at a pulp and chemical factory completed an annual questionnaire regarding psychosocial factors at work using the U.S. National Institute for Occupational Safety and Health Generic Job Stress Questionnaire (i.e., quantitative workload, variance in workload, job control, support from supervisor, coworkers, or family/friends, job satisfaction, and depressive symptoms), as well as daytime sleepiness (through the Epworth Sleepiness Scale [ESS]) and sleep disturbances for three years starting in 2002 (response rates, 94.6–99.0%). The present analysis included 55 day workers (11 women) and 57 shift workers (all men) who participated in all three years of the study, worked under the same work schedule throughout the study period, and had no missing data on any of the daytime sleep items. A repeated‐measures analysis of covariance (ANCOVA) was used to test the effects of work schedule (day vs. shift work) and psychosocial factors at work in 2002 on the ESS scores in subsequent years, with sleep duration, insomnia symptoms, chronic diseases, and sleepiness levels at baseline as covariates. Given significant and near‐significant interactions of work schedules with psychosocial factor or study year, the ANCOVA, with the factors of psychosocial work characteristics and study year, was performed by type of work schedule. The results indicated a significant main effect of psychosocial work characteristics (p=0.010, partial ŋ2=0.14) and an almost significant main effect of study year (p=0.067, partial ŋ2=0.06) and interaction between psychosocial work characteristics and study year (p=0.085, partial ŋ2=0.06) for variance in workload among the day work group. The day workers reporting high variance in workload in 2002 exhibited significantly higher ESS scores in 2003 and 2004 than did those reporting low variance in workload. The ANCOVA for the shift work group showed a main effect of psychosocial work characteristics for job satisfaction (p=0.026, partial ŋ2=0.10) and depressive symptoms (p=0.094, partial ŋ2=0.06) with the interaction between psychosocial work characteristics and study year for job satisfaction (p=0.172, partial ŋ2=0.04) and depressive symptoms (p=0.035, partial ŋ2=0.07). The shift workers with low job satisfaction and high symptoms of depression in 2002 showed significantly greater ESS scores in 2003 and/or 2004 than did those with opposite characteristics. These results may suggest a potential predictive value of variance in workload for day workers as well as job satisfaction and depressive symptoms for shift workers with respect to daytime sleepiness. The present findings may imply that redesigning these aspects of work environment would be of help in managing daytime sleepiness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chronobiology International: The Journal of Biological & Medical Rhythm Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DROWSINESS
KW - PSYCHOSOCIAL factors
KW - EMPLOYEES -- Workload
KW - WORK measurement
KW - JOB satisfaction -- Testing
KW - WORK environment -- Psychological aspects
KW - WORKING hours
KW - ANALYSIS of covariance
KW - Daytime sleepiness
KW - Psychosocial work characteristics
KW - Shift work
KW - sleepiness
KW - Work schedules
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 23518779; Takahashi, Masaya 1; Email Address: takaham@h.jniosh.go.jp Nakata, Akinori 1 Haratani, Takashi 1 Otsuka, Yasumasa 1 Kaida, Kosuke 1,2 Fukasawa, Kenji 1; Affiliation: 1: National Institute of Occupational Safety and Health, Tama-ku, Kawasaki, Japan 2: Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan; Source Info: 2006, Vol. 23 Issue 6, p1409; Subject Term: DROWSINESS; Subject Term: PSYCHOSOCIAL factors; Subject Term: EMPLOYEES -- Workload; Subject Term: WORK measurement; Subject Term: JOB satisfaction -- Testing; Subject Term: WORK environment -- Psychological aspects; Subject Term: WORKING hours; Subject Term: ANALYSIS of covariance; Author-Supplied Keyword: Daytime sleepiness; Author-Supplied Keyword: Psychosocial work characteristics; Author-Supplied Keyword: Shift work; Author-Supplied Keyword: sleepiness; Author-Supplied Keyword: Work schedules; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 14p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/07420520601100963
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huizhong Chen
AU - Hopper, Sherryll L.
AU - Xin-Liang Li
AU - Ljungdahl, Lars G.
AU - Cerniglia, Carl E.
T1 - Isolation of Extremely AT-Rich Genomic DNA and Analysis of Genes Encoding Carbohydrate-Degrading Enzymes from Orpinomyces sp. Strain PC-2.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 2006/11//
VL - 53
IS - 5
M3 - Article
SP - 396
EP - 400
PB - Springer Science & Business Media B.V.
SN - 03438651
AB - An effective method for extraction of intact genomic DNA from the extremely AT-rich polycentric anaerobic fungus Orpinomyces sp. strain PC-2 has been developed. This procedure involves removal of glycogen-like storage polysaccharides using hexadecyltrimethylammonium bromide (CTAB) and high salt washes. The DNA was digested with various restriction enzymes and was suitable for use as a PCR template, for Southern blotting, and for genomic library construction. Genomic DNA analysis of three representative genes ( celE, bgl1, and xynA) encoding (hemi-) cellulolytic enzymes of the fungus revealed multiplicity of family 5 endocellulase genes ( celE-like), and family 1 β-glucosidase genes ( bgl1-like), but only a single copy of family 11 xylanase gene ( xynA). [ABSTRACT FROM AUTHOR]
AB - Copyright of Current Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - Xylanases
KW - Glycosidases
KW - Genes
KW - Enzymes
N1 - Accession Number: 22930325; Huizhong Chen 1; Email Address: huizhong.chen@fda.hhs.gov; Hopper, Sherryll L. 1; Xin-Liang Li 2; Ljungdahl, Lars G. 3; Cerniglia, Carl E. 1; Affiliations: 1: Division of Microbiology , National Center for Toxicological Research, U.S. FDA , 3900 NCTR Rd., Jefferson 72079 USA; 2: Fermentation Biotechnology Research Unit , National Center for Agricultural Utilization Research, USDA/ARS , 1815 N. University Street Peoria 61604 USA; 3: Department of Biochemistry and Molecular Biology and Center for Biological Resource Recovery , The University of Georgia , Athens 30602 USA; Issue Info: Nov2006, Vol. 53 Issue 5, p396; Subject Term: DNA; Subject Term: Xylanases; Subject Term: Glycosidases; Subject Term: Genes; Subject Term: Enzymes; Number of Pages: 5p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1007/s00284-006-0098-2
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106287800
T1 - Risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus bacteraemia: a case-control study.
AU - Carnicer-Pont D
AU - Bailey KA
AU - Mason BW
AU - Walker AM
AU - Evans MR
AU - Salmon RL
Y1 - 2006/11//
N1 - Accession Number: 106287800. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Bacteremia -- Epidemiology
KW - Community-Acquired Infections -- Epidemiology
KW - Cross Infection -- Epidemiology
KW - Methicillin Resistance
KW - Methicillin -- Pharmacodynamics
KW - Staphylococcal Infections -- Risk Factors
KW - Staphylococcus Aureus -- Drug Effects
KW - Bacteremia -- Etiology
KW - Case Control Studies
KW - Chi Square Test
KW - Community-Acquired Infections -- Complications
KW - Community-Acquired Infections -- Etiology
KW - Community-Acquired Infections -- Prevention and Control
KW - Confidence Intervals
KW - Cross Infection -- Complications
KW - Cross Infection -- Prevention and Control
KW - Data Analysis Software
KW - Logistic Regression
KW - Multivariate Analysis
KW - Odds Ratio
KW - Questionnaires
KW - Staphylococcal Infections -- Epidemiology
KW - Staphylococcal Infections -- Microbiology
KW - Univariate Statistics
KW - Unpaired T-Tests
KW - Human
SP - 1167
EP - 1173
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 134
IS - 6
PB - Cambridge University Press
AB - A case-control study was undertaken in an acute district general hospital to identify risk factors for hospital-acquired bacteraemia caused by methicillin-resistant Staphylococcus aureus (MRSA). Cases of hospital-acquired MRSA bacteraemia were defined as consecutive patients from whom MRSA was isolated from a blood sample taken on the third or subsequent day after admission. Controls were randomly selected from patients admitted to the hospital over the same time period with a length of stay of more than 2 days who did not have bacteraemia. Data on 42 of the 46 cases of hospital-acquired bacteraemia and 90 of the 92 controls were available for analysis. There were no significant differences in the age or sex of cases and controls. After adjusting for confounding factors, insertion of a central line [adjusted odds ratio (aOR) 35.3, 95% confidence interval (CI) 3.8-325.5] or urinary catheter (aOR 37.1, 95% CI 7.1-193.2) during the admission, and surgical site infection (aOR 4.3, 95% CI 1.2-14.6) all remained independent risk factors for MRSA bacteraemia. The adjusted population attributable fraction, showed that 51% of hospital-acquired MRSA bacteraemia cases were attributable to a urinary catheter, 39% to a central line, and 16% to a surgical site infection. In the United Kingdom, measures to reduce the incidence of hospital-acquired MRSA bacteraemia in acute general hospitals should focus on improving infection control procedures for the insertion and, most importantly, care of central lines and urinary catheters.
SN - 0950-2688
AD - National Public Health Service for Wales, Communicable Disease Surveillance Centre, Abton House, Cardiff, UK.
U2 - PMID: 16623990.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kioi, Mitomu
AU - Seetharam, Saraswathy
AU - Puri, Raj K.
T1 - N-linked glycosylation of IL-13Rð2 is essential for optimal IL-13 inhibitory activity.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2006/11//
VL - 20
IS - 13
M3 - Article
SP - 2378
EP - 2380
AB - This article discusses a study which aimed to develop a novel inhibitor of human interleukin-13 (IL-13). The study considered the role of IL-13 as a central mediator of allergic, pulmonary, parasitic, and neoplastic diseases. The researchers also determined whether glycosylation of soluble protein might have an essential role in its biological activities.
KW - INTERLEUKIN-13
KW - INTERLEUKINS
KW - ALLERGY
KW - PARASITIC diseases
KW - GLYCOSYLATION
N1 - Accession Number: 23182551; Kioi, Mitomu 1 Seetharam, Saraswathy 1 Puri, Raj K. 1; Email Address: raj.puri@fda.hhs.gov; Affiliation: 1: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA; Source Info: Nov2006, Vol. 20 Issue 13, p2378; Subject Term: INTERLEUKIN-13; Subject Term: INTERLEUKINS; Subject Term: ALLERGY; Subject Term: PARASITIC diseases; Subject Term: GLYCOSYLATION; Number of Pages: 3p; Illustrations: 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1096/fj.06-5995fje
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Selden, Thomas M.
AU - Gray, Bradley M.
T1 - Tax Subsidies For Employment-Related Health Insurance: Estimates For 2006.
JO - Health Affairs
JF - Health Affairs
Y1 - 2006/11//Nov/Dec2006
VL - 25
IS - 6
M3 - Article
SP - 1568
EP - 1579
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Employment-related health insurance is subsidized through exemptions from federal and state income taxes, as well as from taxes for Social Security and Medicare. Proposals to modify this subsidy are a perennial subject of policy debate. We present tax-subsidy projections from a new data resource constructed using a statistical linkage between the establishment and household components of the Medical Expenditure Panel Survey (MEPS). We project that the total federal and state tax subsidy in 2006 for employment-related coverage of active workers will exceed $200 billion. We present per worker tax-subsidy estimates and an analysis of insurance incidence by establishment characteristics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYER-sponsored health insurance
KW - HEALTH insurance
KW - INSURANCE -- State supervision
KW - GOVERNMENT aid
KW - MEDICAL care costs
KW - UNITED States
N1 - Accession Number: 23124805; Selden, Thomas M. 1; Email Address: tselden@ahrq.gov Gray, Bradley M. 2; Affiliation: 1: Economist, Center for Financing, Access, and Cost Trends, Division of Modeling and Simulation, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland 2: Economist, Health Care Operations and Policy Research Center, CNA Corporation, Alexandria, Virginia; Source Info: Nov/Dec2006, Vol. 25 Issue 6, p1568; Subject Term: EMPLOYER-sponsored health insurance; Subject Term: HEALTH insurance; Subject Term: INSURANCE -- State supervision; Subject Term: GOVERNMENT aid; Subject Term: MEDICAL care costs; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 12p; Document Type: Article
L3 - 10.1377/hlthaff.25.6.1568
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23124805&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106237363
T1 - Tax subsidies for employment-related health insurance: estimates for 2006: the tax subsidy is poorly targeted if the goal is to stem the rising numbers of people without insurance or with public insurance.
AU - Selden TM
AU - Gray BM
Y1 - 2006/11//Nov/Dec2006
N1 - Accession Number: 106237363. Language: English. Entry Date: 20070216. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Employment
KW - Insurance, Health -- Economics
KW - Taxes
KW - Data Collection
KW - Descriptive Statistics
KW - Linear Regression
KW - Medically Uninsured
KW - Multivariate Analysis
KW - Private Sector
KW - Public Sector
KW - Secondary Analysis
KW - Human
SP - 1568
EP - 1579
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 25
IS - 6
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Employment-related health insurance is subsidized through exemptions from federal and state income taxes, as well as from taxes for Social Security and Medicare. Proposals to modify this subsidy are a perennial subject of policy debate. We present tax-subsidy projections from a new data resource constructed using a statistical linkage between the establishment and household components of the Medical Expenditure Panel Survey (MEPS). We project that the total federal and state tax subsidy in 2006 for employment-related coverage of active workers will exceed $200 billion. We present per worker tax-subsidy estimates and an analysis of insurance incidence by establishment characteristics.
SN - 0278-2715
AD - Center for Financing, Access, and Cost Trends, Division of Modeling and Simulation, Agency for Healthcare Research and Quality (AHRQ), in Rockville, Maryland.
U2 - PMID: 17102182.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106237363&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106237268
T1 - Getting to 'smart' health care.
AU - Clancy CM
Y1 - 2006/11//Nov/Dec2006
N1 - Accession Number: 106237268. Language: English. Entry Date: 20070216. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Consumer Participation
KW - Health Services -- Economics
KW - Outcomes (Health Care)
KW - Decision Making
KW - Health Information
KW - Information Technology
SP - w589
EP - 92
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 25
IS - 6
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - As the United States struggles with improving the return on its sizable health care investment and consumers become increasingly involved in health care decisions, interest in comparative effectiveness will rise because of its relevance to value, personalized health care, quality, and cost containment. Advances in biomedicine and health information technology present exciting opportunities for providing timely, relevant information about the comparative effectiveness of health care services. Successful growth will require a transparent, participatory approach and new partnerships between the public and private sectors to achieve the goal of producing valid evidence for decision making.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality in Rockville, Maryland.
U2 - PMID: 17090557.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106237268&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106223506
T1 - Evaluating an abbreviated version of the Hispanic Stress Inventory for Immigrants.
AU - Cavazos-Rehg PA
AU - Zayas LH
AU - Walker MS
AU - Fisher EB
Y1 - 2006/11//
N1 - Accession Number: 106223506. Language: English. Entry Date: 20070126. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Hispanic Stress Inventory-Immigrant version (HSI-I); Emotional Distress Scale (Carver et al). Grant Information: Grant, National Heart, Lung, and Blood Institute (No. 5 T32 HL07456). NLM UID: 9426485.
KW - Acculturation
KW - Hispanics
KW - Instrument Validation
KW - Stress, Psychological
KW - Adult
KW - Coefficient Alpha
KW - Descriptive Statistics
KW - Factor Analysis
KW - Female
KW - Funding Source
KW - Immigrants -- United States
KW - Internal Consistency
KW - Male
KW - P-Value
KW - Pearson's Correlation Coefficient
KW - Questionnaires
KW - Sample Size
KW - Scales
KW - Self Report
KW - United States
KW - Human
SP - 498
EP - 515
JO - Hispanic Journal of Behavioral Sciences
JF - Hispanic Journal of Behavioral Sciences
JA - HISPANIC J BEHAV SCI
VL - 28
IS - 4
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - This study evaluates an abbreviated version of the Hispanic Stress Inventory-Immigrant version (HSI-I) with a nonclinical sample of 143 adult Hispanic immigrants residing in a large midwestern city. The HSI-I consists of 73 items and 5 distinct subscales that assess psychosocial experiences on five dimensions, namely, occupational/economic, parental, marital, immigration, and familial/cultural. Five items with the greatest loading in each of the five sub-scales were aggregated to compose the abbreviated HSI-I. Exploratory factor analysis supports a two-factor structure that combines factors identified in previous research. Internal consistencies are acceptable across all subscales, ranging from .68 to .83. Convergent validity of the abbreviated HSI-I revised is supported with moderately positive relations through self-report measures of depression, anxiety, and anger mood levels. These findings provide initial support for the reliability and validity of the abbreviated HSI-I in Hispanic adults.
SN - 0739-9863
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, One Brookings Drive, Campus Box 1093, St. Louis, MO 63130-4899; pcavazos@im.wustl.edu
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106223506&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yousef, Walees A.
AU - Wagner, Robert F.
AU - Loew, Murray H.
T1 - Assessing Classifiers from Two Independent Data Sets Using ROC Analysis: A Nonparametric Approach.
JO - IEEE Transactions on Pattern Analysis & Machine Intelligence
JF - IEEE Transactions on Pattern Analysis & Machine Intelligence
Y1 - 2006/11//
VL - 28
IS - 11
M3 - Article
SP - 1809
EP - 1817
SN - 01628828
AB - This paper considers binary classification. We assess a classifier in terms of the Area Under the ROC Curve (AUC). We estimate three important parameters, the conditional AUC (conditional on a particular training set) and the mean and variance of this AUC. We derive, as well, a closed form expression of the variance of the estimator of the AUC. This expression exhibits several components of variance that facilitate an understanding for the sources of uncertainty of that estimate. In addition, we estimate this variance, i.e., the variance of the conditional AUC estimator. Our approach is nonparametric and based on general methods from U-statistics; it addresses the case where the data distribution is neither known nor modeled and where there are only two available data sets, the training and testing sets. Finally, we illustrate some simulation results for these estimators. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Pattern Analysis & Machine Intelligence is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BINARY system (Mathematics)
KW - DISTRIBUTION (Probability theory)
KW - MATHEMATICAL optimization
KW - MATHEMATICAL statistics
KW - CORRELATION (Statistics)
KW - SIMULATION methods & models
KW - ANALYSIS of variance
KW - Classification
KW - nonparametric statistics
KW - ROC analysis
N1 - Accession Number: 22785935; Yousef, Walees A. 1; Email Address: wyousef@aucegypt.edu Wagner, Robert F. 1; Email Address: Robert.Wagner@fda.hhs.gov Loew, Murray H. 2; Email Address: Ioew@gzvu.edu; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, 12720 Twinbrook Parkway, Rockville, MD 20852 (HFZ 140) 2: George Washington University, Room 624A Phillips Hall, 801 22nd St. NW, Washington DC 20052; Source Info: Nov2006, Vol. 28 Issue 11, p1809; Subject Term: BINARY system (Mathematics); Subject Term: DISTRIBUTION (Probability theory); Subject Term: MATHEMATICAL optimization; Subject Term: MATHEMATICAL statistics; Subject Term: CORRELATION (Statistics); Subject Term: SIMULATION methods & models; Subject Term: ANALYSIS of variance; Author-Supplied Keyword: Classification; Author-Supplied Keyword: nonparametric statistics; Author-Supplied Keyword: ROC analysis; Number of Pages: 9p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Loree, Jonathan
AU - Koturbash, Igor
AU - Kutanzi, Kristy
AU - Baker, Mike
AU - Pogribny, Igor
AU - Kovalchuk, Olga
T1 - Radiation-induced molecular changes in rat mammary tissue: Possible implications for radiation-induced carcinogenesis.
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
Y1 - 2006/11//
VL - 82
IS - 11
M3 - Article
SP - 805
EP - 815
PB - Taylor & Francis Ltd
SN - 09553002
AB - Purpose: Ionizing radiation is a potent mammary gland carcinogen, yet the exact molecular etiology of radiation-induced breast cancer remains unknown.Materials and methods: Our study utilized a rat model of breast carcinogenesis to analyse the molecular and epigenetic changes induced in mammary gland tissue upon exposure to ionizing radiation (IR). Using a methylation-sensitive cytosine extension assay we studied the IR-induced changes in DNA methylation. In parallel, we analysed the expression of proteins involved in DNA methylation, DNA repair and cell proliferation control. Molecular changes were related to cellular proliferation and apoptosis.Results: We found that IR led to a loss of genomic cytosine methylation in the exposed mammary tissue. Global DNA hypomethylation was paralleled by reduction in the levels of maintenance (DNMT1) and de novo (DNMT3a and 3b) DNA methyltransferases and methyl-binding protein MeCP2. The observed DNA hypomethylation was linked, at least in part, to activation of DNA repair processes. Concurrently, we observed increased levels of phosphorylated extracellular signal-regulated kinase (p-ERK1/2), phosphorylated AKT kinase (p-AKT), cyclin D1 and proliferating cells nuclear antigen (PCNA) proteins, suggesting IR alters intra-cellular signaling and cell cycle control mechanisms in mammary tissue. We also noted a significant induction of apoptosis in the exposed tissue 6 hours after irradiation. The observed apoptosis levels were paralleled by the slight elevation of cellular proliferation.Conclusions: We have demonstrated that a single exposure to 5 Gy of X rays leads to noticeable epigenetic changes in the rat mammary gland that occurred in the context of activation of DNA damage repair and alterations in the pro-survival growth-stimulatory cellular signaling pathways. The possible cellular repercussions of the observed changes in relationship to breast carcinogenesis are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Radiation Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IONIZING radiation
KW - RADIATION
KW - BREAST cancer
KW - CARCINOGENESIS
KW - DNA
KW - apoptosis
KW - cellular proliferation
KW - DNA methylation
KW - DNA repair
KW - mammary tissue
KW - Radiation
KW - signaling
N1 - Accession Number: 23311734; Loree, Jonathan 1 Koturbash, Igor 1 Kutanzi, Kristy 1 Baker, Mike 1 Pogribny, Igor 2 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arizona, USA; Source Info: Nov2006, Vol. 82 Issue 11, p805; Subject Term: IONIZING radiation; Subject Term: RADIATION; Subject Term: BREAST cancer; Subject Term: CARCINOGENESIS; Subject Term: DNA; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: cellular proliferation; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: DNA repair; Author-Supplied Keyword: mammary tissue; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: signaling; Number of Pages: 11p; Illustrations: 1 Color Photograph, 4 Graphs; Document Type: Article
L3 - 10.1080/09553000600960027
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DP - EBSCOhost
DB - aph
ER -
TY - CASE
AU - Antao, V.C.
AU - Petsonk, E.L.
AU - Attfield, M.D.
T1 - Advanced Cases of Coal Workers' Pneumoconiosis-- Two Counties, Virginia, 2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/11//11/1/2006
VL - 296
IS - 17
M3 - Case Study
SP - 2085
EP - 2086
SN - 00987484
AB - The article presents a report from the U.S. Centers for Disease Control and Prevention that describes cases of advanced coal workers' pneumoconiosis in coal miners from Lee County and Wise County in Virginia. Coal workers' pneumoconiosis is an occupational lung disease caused by the inhalation of coal mine dust. Some of the coal miners also met criteria for progressive massive fibrosis, a disabling and potentially fatal form of the occupational disease. The cases presented were identified through the Enhanced Coal Workers' Health Surveillance Program.
KW - LUNGS -- Dust diseases
KW - OCCUPATIONAL diseases
KW - COAL miners
KW - DISEASES
KW - LUNG diseases
KW - VIRGINIA
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 22911080; Antao, V.C. 1 Petsonk, E.L. 1 Attfield, M.D. 1; Affiliation: 1: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 11/1/2006, Vol. 296 Issue 17, p2085; Subject Term: LUNGS -- Dust diseases; Subject Term: OCCUPATIONAL diseases; Subject Term: COAL miners; Subject Term: DISEASES; Subject Term: LUNG diseases; Subject Term: VIRGINIA; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Case Study
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106228024
T1 - A primer on economic evaluations related to expansion of newborn screening for genetic and metabolic disorders.
AU - Hubbard HB
Y1 - 2006/11//Nov/Dec2006
N1 - Accession Number: 106228024. Language: English. Entry Date: 20070202. Revision Date: 20150818. Publication Type: Journal Article; review. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8503123.
KW - Health Screening -- Economics -- In Infancy and Childhood
KW - Hereditary Diseases -- Diagnosis
KW - Neonatal Assessment -- Economics
KW - Cost Benefit Analysis
KW - Geographic Factors
KW - Infant, Newborn
KW - Research
KW - United States
SP - 692
EP - 699
JO - JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing
JF - JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing
JA - JOGNN
VL - 35
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Newborns in every state are screened for genetic/metabolic disorders, but there is no uniform national screening program. Recently, a federal panel concluded that the number of disorders screened should be increased from 9 to Twentynine. In order for state leaders, and for the clinicians who inform them, to make sound decisions about expanding newborn screening programs, they need to be aware of the costs and outcomes of the entire screening program. This paper examines newborn screening from several perspectives: status of state programs, screening technology, and financing. In addition, various types of economic evaluations are defined, and a number of economic studies are explored.
SN - 0884-2175
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Room 3337, Rockville, MD 20850; heddy.hubbard@ahrq.hhs.gov
U2 - PMID: 17105633.
DO - 10.1111/j.1552-6909.2006.00098.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hubbard, Heddy Bishop
T1 - A Primer on Economic Evaluations Related to Expansion of Newborn Screening for Genetic and Metabolic Disorders.
JO - JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing
JF - JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing
Y1 - 2006/11//Nov/Dec2006
VL - 35
IS - 6
M3 - Article
SP - 692
EP - 699
SN - 08842175
AB - Newborns in every state are screened for genetic/metabolic disorders, but there is no uniform national screening program. Recently, a federal panel concluded that the number of disorders screened should be increased from 9 to Twentynine. In order for state leaders, and for the clinicians who inform them, to make sound decisions about expanding newborn screening programs, they need to be aware of the costs and outcomes of the entire screening program. This paper examines newborn screening from several perspectives: status of state programs, screening technology, and financing. In addition, various types of economic evaluations are defined, and a number of economic studies are explored. JOGNN, 35, 692-699; 2006. DOI: 10.1111/J.1552-6909.2006.00098.x [ABSTRACT FROM AUTHOR]
AB - Copyright of JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEWBORN infants -- Diseases
KW - GENETIC disorders
KW - METABOLIC disorders
KW - MEDICAL screening
KW - MEDICAL personnel
KW - DIAGNOSIS
KW - MEDICAL care
KW - Costs and Outcomes
KW - Decision Modeling
KW - Economic Evaluations
KW - Genetic and Metabolic Disorders
KW - Newborn Screening
N1 - Accession Number: 23017887; Hubbard, Heddy Bishop 1; Email Address: heddy.hubbard@ahrq.hhs.gov; Source Information: Nov/Dec2006, Vol. 35 Issue 6, p692; Subject: NEWBORN infants -- Diseases; Subject: GENETIC disorders; Subject: METABOLIC disorders; Subject: MEDICAL screening; Subject: MEDICAL personnel; Subject: DIAGNOSIS; Subject: MEDICAL care; Author-Supplied Keyword: Costs and Outcomes; Author-Supplied Keyword: Decision Modeling; Author-Supplied Keyword: Economic Evaluations; Author-Supplied Keyword: Genetic and Metabolic Disorders; Author-Supplied Keyword: Newborn Screening; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1552-6909.2006.00098.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 106239991
T1 - Choosing the right antibiotic in ambulatory care.
AU - Anderson VL
AU - Miskinis-Hilligoss D
Y1 - 2006/11//
N1 - Accession Number: 106239991. Language: English. Entry Date: 20070223. Revision Date: 20150818. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 101264817.
KW - Advanced Nursing Practice
KW - Ambulatory Care
KW - Antibiotics
KW - Decision Making, Clinical
KW - Infection -- Drug Therapy
KW - Antibiotics -- Administration and Dosage
KW - Antibiotics -- Adverse Effects
KW - Antibiotics -- Classification
KW - Antifungal Agents -- Administration and Dosage
KW - Antifungal Agents -- Adverse Effects
KW - Bacteria
KW - Bites, Human
KW - Bronchitis
KW - Cellulitis
KW - Community-Acquired Pneumonia
KW - Cystitis
KW - Diagnosis, Differential
KW - Diarrhea
KW - Epididymitis
KW - Fasciitis, Necrotizing
KW - Folliculitis
KW - Fungi
KW - Furunculosis
KW - Impetigo
KW - Infection -- Classification
KW - Infection -- Diagnosis
KW - Infection -- Etiology
KW - Lyme Disease
KW - Mycoses
KW - Onychomycosis
KW - Otitis Media
KW - Paronychia
KW - Lice Infestations
KW - Pharyngitis
KW - Scabies
KW - Sexually Transmitted Diseases -- Drug Therapy
KW - Sinusitis
KW - Vaginitis
SP - 682
EP - 704
JO - Journal for Nurse Practitioners
JF - Journal for Nurse Practitioners
JA - J NURSE PRACT
VL - 2
IS - 10
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - The goal of this article is to be a quick guide for the nurse practitioner practicing in an ambulatory setting for making the right antibiotic choice for the right infection. With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common causative organisms and gives antibiotic options with respect to efficacy, common side effects, and cost. We provide recommendations for length of therapy and follow-up, as well.
SN - 1555-4155
AD - Officer, US Public Health Service, National Institutes of Health, Director of Clinical Services, Laboratory of Clinical Infectious Diseases, National Institutes of Allergy and Infectious Diseases; VANDERSON@niaid.nih.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ruder, A. M.
AU - Waters, M. A.
AU - Carreón, T.
AU - Butler, M. A.
AU - Davis-King, K. E.
AU - Calvert, G. M.
AU - Schulte, P. A.
AU - Ward, E. M.
AU - Connally, L. B.
AU - Lu, J.
AU - Wall, D.
AU - Zivkovich, Z.
AU - Heineman, E. F.
AU - Mandel, J. S.
AU - Morton, R. F.
AU - Reding, D. J.
AU - Rosenman, K. D.
T1 - The Upper Midwest Health Study: A Case-Control Study of Primary Intracranial Gliomas in Farm and Rural Residents.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2006/11//
VL - 12
IS - 4
M3 - Article
SP - 255
EP - 274
SN - 10747583
AB - The article focuses on the Upper Midwest Health Study initiated by the National Institute for Occupational Safety and Health to examine the risk of intracranial glioma in farm and rural residents in the United States. The population-based, case-control study evaluated the relationship between gliomas and rural and farm exposures among adults. Participants lived in non-metropolitan counties where the largest population center had fewer than 250,000 residents. Cases were diagnosed January 1, 1995 through January 31, 1997. Results show that moving to a farm as an adolescent was associated with greater risk of glioma.
KW - Health risk assessment
KW - Occupational hazards
KW - Agriculture
KW - Research
KW - Rural geography
KW - Brain cancer
KW - Nervous system -- Tumors
KW - Country life
KW - United States
KW - Agricultural workers
KW - Agrochemicals
KW - Case-control study
KW - Glioma
KW - Proxy
KW - Study design
N1 - Accession Number: 23024939; Ruder, A. M. 1; Email Address: amr2@cdc.gov.; Waters, M. A. 2; Carreón, T. 3; Butler, M. A. 4; Davis-King, K. E.; Calvert, G. M. 5; Schulte, P. A. 6; Ward, E. M.; Connally, L. B. 7; Lu, J. 8; Wall, D. 9; Zivkovich, Z. 8; Heineman, E. F.; Mandel, J. S.; Morton, R. F. 10; Reding, D. J. 11; Rosenman, K. D. 12; Affiliations: 1: Senior Research Epidemiologist, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Senior Research Health Scientist, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Fellow, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 4: Toxicologist, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 5: Medical Officer, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 6: Division Director,, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 7: Notification Officer, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 8: Programmer, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 9: Statistician, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 10: Mercy Medical Center, Des Moines, Iowa; 11: National Farm Medicine Center, Marshfield Clinic, Marshfield, Wisconsin; 12: Michigan State University, East Lansing, Michigan; Issue Info: Nov2006, Vol. 12 Issue 4, p255; Thesaurus Term: Health risk assessment; Thesaurus Term: Occupational hazards; Thesaurus Term: Agriculture; Thesaurus Term: Research; Thesaurus Term: Rural geography; Subject Term: Brain cancer; Subject Term: Nervous system -- Tumors; Subject Term: Country life; Subject: United States; Author-Supplied Keyword: Agricultural workers; Author-Supplied Keyword: Agrochemicals; Author-Supplied Keyword: Case-control study; Author-Supplied Keyword: Glioma; Author-Supplied Keyword: Proxy; Author-Supplied Keyword: Study design; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 20p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sharpless, Katherine E.
AU - Anderson, David L.
AU - Betz, Joseph
AU - Butler, Therese A.
AU - Capara, Stephen G.
AU - Cheng, John
AU - Fraser, Catharine A.
AU - Gardner, Graeme
AU - Gay, Martha L.
AU - Howell, Daniel W.
AU - Ihara, Toshihide
AU - Masoor A. Khan
AU - Lam, Joseph W.
AU - Long, Stephen E.
AU - McCoeye, Margaret
AU - Mackey, Elizabth A.
AU - Mindak, William R.
AU - Mitvalsky, Staci
AU - Murphy, Karen E.
AU - NguyenPho, Agnes
T1 - Preparation and Characterization of a Suite of Ephedra-Containing Standard Reference Materials.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/11//Nov/Dec2006
VL - 89
IS - 6
M3 - Article
SP - 1483
EP - 1495
SN - 10603271
AB - The article describes the preparation of a suite of ephedra-containing standard reference materials (SRM) for dietary supplements by various administrative agencies in the United States. Materials in the suite of SRM are intended for use as primary control materials when values are assigned to in-house control materials and for validation of analytical methods for the measurement of alkaloids, toxic elements and nutrients in similar materials.
KW - DIETARY supplements
KW - REFERENCE sources
KW - EPHEDRA
KW - GOVERNMENT agencies
KW - UNITED States
N1 - Accession Number: 23466939; Sharpless, Katherine E. 1; Email Address: katherine.sharpIess@nist.gov Anderson, David L. 2 Betz, Joseph 3 Butler, Therese A. 4 Capara, Stephen G. 2 Cheng, John 2 Fraser, Catharine A. 5 Gardner, Graeme 5 Gay, Martha L. 2 Howell, Daniel W. 6 Ihara, Toshihide 4 Masoor A. Khan 7 Lam, Joseph W. 8 Long, Stephen E. 4 McCoeye, Margaret 8 Mackey, Elizabth A. 9 Mindak, William R. 2 Mitvalsky, Staci 10 Murphy, Karen E. 11 NguyenPho, Agnes 7; Affiliation: 1: National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-8390 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740-3835 3: National Institutes of Health, Office of Dietary Supplements, Bethesda, MD 20892 4: National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-8392 5: National Research Council Canada, Ottawa, Ontario, Canada K IA 0R9 6: Food Products Association, Washington, DC 20005 7: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993 8: National Research Council Canada, Ottawa, Ontario, Canada KIA 0R9 9: National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-8395 10: ChromaDex, Inc., Clearwater, FL 33760 11: National Institute of Standards and Technology, Analytical Chemistry Division, Gaithersburg, MD 20899-839 I; Source Info: Nov/Dec2006, Vol. 89 Issue 6, p1483; Subject Term: DIETARY supplements; Subject Term: REFERENCE sources; Subject Term: EPHEDRA; Subject Term: GOVERNMENT agencies; Subject Term: UNITED States; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 13p; Illustrations: 2 Diagrams, 7 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marks, Heidi S.
AU - Anderson, Collin R.
T1 - Rapid Determination and Confirmation of Biogenic Amines in Tuna Loin by Gas Chromatography/Mass Spectrometry Using Ethyichioroformate Derivative.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/11//Nov/Dec2006
VL - 89
IS - 6
M3 - Article
SP - 1591
EP - 1599
SN - 10603271
AB - The article describes the use of gas chromatography and mass spectrometry methods to rapidly determine and confirm the biogenic amines in tuna loin using ethylchloroformate derivative. The method may also be used to monitor tyramine, which involves homogenization of fish tissue, extraction of biogenic amines into trichloroacetic acid solution, and derivatization of supernatant with ethylchloroformate.
KW - BIOGENIC amines
KW - TUNA
KW - GAS chromatography
KW - MASS spectrometry
KW - TISSUES -- Analysis
KW - FISHES
N1 - Accession Number: 23466953; Marks, Heidi S. 1; Email Address: heidi.marks@fda.hhs.gov Anderson, Collin R. 1; Affiliation: 1: U.S. Food and Drug Administration, Seafood Products Research Center, Pacific Regional Laboratory Northwest, 22201 23rd Dr, SE, Bothell, WA 98021; Source Info: Nov/Dec2006, Vol. 89 Issue 6, p1591; Subject Term: BIOGENIC amines; Subject Term: TUNA; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: TISSUES -- Analysis; Subject Term: FISHES; NAICS/Industry Codes: 114111 Finfish Fishing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McClure, Foster D.
AU - Lee, Jung K.
T1 - On Determining a 1-Tailed Upper Limit for Future Sample HorRat Values.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2006/11//Nov/Dec2006
VL - 89
IS - 6
M3 - Article
SP - 1650
EP - 1663
SN - 10603271
AB - The article describes the development of two formulas for use in computing one-tailed upper limits for future HorRat values obtained from the collaborative study of materials. The formulas will prove to be useful to Study Directors in determining worst case scenarios concerning a method's reproducibility precision relative to that predicted using Horwitz equation.
KW - MATHEMATICAL formulas
KW - RESEARCH
KW - MATERIALS
KW - STATISTICS
KW - MATHEMATICS
N1 - Accession Number: 23466961; McClure, Foster D. 1; Email Address: foster.rncclure@fda.hhs.gov Lee, Jung K. 1; Affiliation: 1: Department of Health and Human Services, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Nov/Dec2006, Vol. 89 Issue 6, p1650; Subject Term: MATHEMATICAL formulas; Subject Term: RESEARCH; Subject Term: MATERIALS; Subject Term: STATISTICS; Subject Term: MATHEMATICS; Number of Pages: 14p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meleg, E.
AU - Jakab, F.
AU - Kocsis, B.
AU - Bányai, K.
AU - Melegh, B.
AU - Szűcs, G.
T1 - Human astroviruses in raw sewage samples in Hungary.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2006/11//
VL - 101
IS - 5
M3 - Article
SP - 1123
EP - 1129
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: Routine procedures for monitoring viruses in water samples have not been drawn up for the water-microbiology screening panel. Enteric viruses, including astroviruses, are able to persist under environmental conditions and may cause public health problems by contaminating natural and drinking water resources. The aim of this study was to detect human astroviruses (HAstVs) from raw wastewater samples. Methods and Results: To obtain data on whether human astroviruses are shed in the environment, 35 raw sewage samples from 22 sewage plants in different regions of Baranya County, Hungary were tested for astrovirus using a polyethylene glycol method for concentration and a guanidinium thiocyanate–silica procedure for extraction of viral RNA. Reverse transcription-polymerase chain reaction (RT-PCR) with HAstV-specific primer pairs was used for amplification and the specificity of amplicons was confirmed by nucleotide sequencing and phylogenetic analysis. Among the 35 raw sewage samples, 15 (43%) contained HAstV and by sequence analysis, 10 genotype HAstV-1 and one genotype HAstV-2 were identified. Conclusions: The high detection rate of astroviruses we encountered in this study provide convincing evidence that HAstVs circulate at a relatively high frequency in the Hungarian population. No correlation between the standard indicators of faecal pollution and the presence of HAstVs was found. Significance and Impact of the Study: Our study is the first report on detection of HAstV in sewage in Hungary and suggests that HAstV might be potent indicators of viral pollution in environmental specimens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Sewage -- Microbiology
KW - RNA viruses
KW - Polyethylene glycol
KW - Polymerase chain reaction
KW - Nucleotide sequence
KW - astroviruses
KW - guanidinium thiocyanate
KW - HUNGARY
KW - polyethylene glycol
KW - RT-PCR
KW - sewage
N1 - Accession Number: 22674917; Meleg, E. 1,2; Email Address: melegedina@freemail.hu; Jakab, F. 1,2; Kocsis, B. 1; Bányai, K. 1,2; Melegh, B. 3; Szűcs, G. 1,2; Affiliations: 1: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary; 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service,Pécs, Hungary; 3: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Pécs, Hungary; Issue Info: Nov2006, Vol. 101 Issue 5, p1123; Thesaurus Term: Sewage -- Microbiology; Thesaurus Term: RNA viruses; Subject Term: Polyethylene glycol; Subject Term: Polymerase chain reaction; Subject Term: Nucleotide sequence; Author-Supplied Keyword: astroviruses; Author-Supplied Keyword: guanidinium thiocyanate; Author-Supplied Keyword: HUNGARY; Author-Supplied Keyword: polyethylene glycol; Author-Supplied Keyword: RT-PCR; Author-Supplied Keyword: sewage; Number of Pages: 7p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1111/j.1365-2672.2006.02997.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Eui-Cheol Shin
AU - Seifert, Ulrike
AU - Kato, Takanobu
AU - Rice, Charles M.
AU - Feinstone, Stephen M.
AU - Kloetzel, Peter-M.
AU - Rehermann, Barbara
T1 - Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2006/11//
VL - 116
IS - 11
M3 - Article
SP - 3006
EP - 3014
SN - 00219738
AB - IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits, their incorporation into the proteasome complex, and the generation of an immunoproteasome-dependent CD8 T cell epitope in vitro and provide in vivo evidence that this mechanism occurs prior to IFN-γ responses at the site of viral infection. Type I IFN—mediated generation of immunoproteasomes was initiated by either poly(I:C) or HCV RNA in human hepatoma cells and was inhibited by neutralization of type I IFN. In serial liver biopsies of chimpanzees with acute HCV infection, increases in immunoproteasome subunit mRNA preceded intrahepatic IFN-γ responses by several weeks, instead coinciding with intrahepatic type I IFN responses. Thus, viral RNA—induced innate immune responses regulate the antigen-processing machinery, which occurs prior to the detection of IFN-γ at the site of infection. This mechanism may contribute to the high effectiveness (95%) of type I IFN-based therapies if administered early during HCV infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - INTERFERONS
KW - T cells
KW - BIOPSY
KW - HEPATOMA
KW - CANCER cells
KW - IMMUNE response
N1 - Accession Number: 23151596; Eui-Cheol Shin 1,2 Seifert, Ulrike 3 Kato, Takanobu 2 Rice, Charles M. 4 Feinstone, Stephen M. 5 Kloetzel, Peter-M. 3 Rehermann, Barbara 1,2; Email Address: Rehermann@nih.gov; Affiliation: 1: Immunology Section, Department of Health and Human Services, Bethesda, Maryland, USA 2: Liver Diseases Branch, NIDDK, NIH, Department of Health and Human Services, Bethesda, Maryland, USA 3: Institute of Biochemistry, Charité-Universitaetsmedizin Berlin CCM, Berlin, Germany 4: Center for the Study of Hepatitis C, Rockefeller University, New York, New York, USA 5: Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA; Source Info: Nov2006, Vol. 116 Issue 11, p3006; Subject Term: HEPATITIS C virus; Subject Term: INTERFERONS; Subject Term: T cells; Subject Term: BIOPSY; Subject Term: HEPATOMA; Subject Term: CANCER cells; Subject Term: IMMUNE response; Number of Pages: 9p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 6 Graphs; Document Type: Article
L3 - 10.1172/JCI29832
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nordstrom, Jessica L.
AU - Rangdale, Rachel
AU - Vickery, Michael C. L.
AU - Phillips, Andrea M. B.
AU - Murray, Shelley L.
AU - Wagley, Sariqa
AU - Depaola, Angelo
T1 - Evaluation of an Alkaline Phosphatase-Labeled Oligonucleotide Probe for the Detection and Enumeration of the Thermostable-Related Hemolysin (trh) Gene of Vibrio parahaemolyticus.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/11//
VL - 69
IS - 11
M3 - Article
SP - 2770
EP - 2772
SN - 0362028X
AB - Reliable methods are needed to detect total and pathogenic Vibrio parahaemolyticus. One marker of V. parahaemolyticus virulence is the thermostable-related hemolysin. We developed an alkaline phosphatase-labeled DNA probe method for the specific detection and enumeration of trh-positive V. parahaemolyticus by colony hybridization. The probe was tested against a panel of 200 bacterial strains and determined to be specific for trh-positive V. parahaemolyticus. Additionally, the trh alkaline phosphatase probe colony hybridization was successfully used to detect and enumerate trh-positive V. parahaemolyticus in seafood and water samples collected from the United States and the United Kingdom. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virulence (Microbiology)
KW - Vibrio parahaemolyticus
KW - Nucleic acid probes
KW - DNA probes
KW - Hemolysis & hemolysins
KW - Genes
N1 - Accession Number: 23154536; Nordstrom, Jessica L. 1; Email Address: jessica.nordstrom@fda.hhs.gov; Rangdale, Rachel 2; Vickery, Michael C. L. 3; Phillips, Andrea M. B. 4; Murray, Shelley L. 5; Wagley, Sariqa 2; Depaola, Angelo 1; Affiliations: 1: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville Drive, P.O. Box 158, Dauphin Island, Alabama 36528, USA; 2: Centre for Environment, Fisheries & Aquaculture Science, Weymouth Laboratory Weymouth, UK; 3: Cepheid, 904 Caribbean Drive, Sunnyvale, California 94089, USA; 4: Gulf Coast Research Laboratory, University of Southern Mississippi, Ocean Springs, Mississippi 39546, USA; 5: Alaska Department of Environmental Conservation, Anchorage, Alaska 99507, USA; Issue Info: Nov2006, Vol. 69 Issue 11, p2770; Thesaurus Term: Virulence (Microbiology); Subject Term: Vibrio parahaemolyticus; Subject Term: Nucleic acid probes; Subject Term: DNA probes; Subject Term: Hemolysis & hemolysins; Subject Term: Genes; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106124894
T1 - Informed participation in TennCare by people with disabilities.
AU - Hill SC
AU - Wooldridge J
Y1 - 2006/11//
N1 - Accession Number: 106124894. Language: English. Entry Date: 20070727. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Grant Information: U.S. Department of Health and Human Services (DHHS), Assistant Secretary for Planning and Evaluation and the Health Care Financing Administration through a contract with Mathematica Policy Research, Inc.. NLM UID: 9103800.
KW - Consumer Participation
KW - Disabled -- Tennessee
KW - Managed Care Programs -- Tennessee
KW - Medicaid -- Tennessee
KW - Consumer Health Information
KW - Consumer Satisfaction
KW - Data Collection, Computer Assisted
KW - Decision Making
KW - Economic and Social Security
KW - Funding Source
KW - Health Services Accessibility
KW - Interviews
KW - Random Sample
KW - Regression
KW - Surveys
KW - Tennessee
KW - Urban Areas
KW - Human
SP - 851
EP - 875
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 17
IS - 4
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - Informed consumer participation in health care is increasingly important, but people with disabilities face barriers to making health care decisions. Using a unique survey, we examine informed health care choices by nonelderly people with diverse disabilities, including mental retardation, mental illness, visual and hearing impairments, and difficulty communicating, in TennCare, Tennessee's Medicaid managed care program. Most people with disabilities chose their plans and providers, felt they had enough information to choose a plan, and rated information from their providers as good to excellent. A minority did not know they could choose their plans and providers and reported poor or fair communication with providers. Adults with mental retardation were less likely than other adults with disabilities to seek information. Adults with serious difficulty communicating were less satisfied than others with information from providers. Medicare, Medicaid, health plans, and providers should tailor information dissemination to the diverse needs of people with disabilities.
SN - 1049-2089
AD - Service Fellow Economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 17242535.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106240285
T1 - Epidemiology of needlestick and sharps injuries among professional Korean nurses.
AU - Smith DR
AU - Choe M
AU - Jeong JS
AU - Jeon MY
AU - Chae YR
AU - An GJ
Y1 - 2006/11//
N1 - Accession Number: 106240285. Language: English. Entry Date: 20070223. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8511298.
KW - Needlestick Injuries -- Epidemiology -- South Korea
KW - Occupational-Related Injuries -- Epidemiology -- South Korea
KW - Registered Nurses -- South Korea
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Confidence Intervals
KW - Convenience Sample
KW - Cross Sectional Studies
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Hospitals
KW - Logistic Regression
KW - Multiple Regression
KW - Needlestick Injuries -- Classification
KW - Needlestick Injuries -- Etiology
KW - Needlestick Injuries -- Risk Factors
KW - Odds Ratio
KW - Questionnaires
KW - South Korea
KW - Univariate Statistics
KW - Human
SP - 359
EP - 366
JO - Journal of Professional Nursing
JF - Journal of Professional Nursing
JA - J PROF NURS
VL - 22
IS - 6
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Although needlestick and sharps injuries (NSI) are known to affect professional nurses at high rates, most studies depend on officially reported data and few have been undertaken in Korea. Thus, we surveyed a large cross-section of nurses from a hospital in Gangneung (response rate, 97.9%). Four hundred thirty-two incidents of NSI were reported by 263 nurses (79.7%) in the previous 12-month period (average, 1.31 events/nurse/year). Syringe needles were the most common devices, affecting 67.3% and comprising 52% of all NSI events. Sixty percent of all NSI events involved contaminated devices. Opening an ampoule or vial was the most common cause (affecting 35.2% of all nurses and accounting for 15.9% of all NSI events). Logistic regression indicated that nurses working in 'other' departments were 5.4 times more likely to suffer any NSI (odds ratio [OR] = 5.4; 95% confidence interval [95% CI] = 2.0-15.2; P < .05) and 4.7 times more likely to incur a syringe-needle injury than nurses in intensive care units or inpatient departments (OR = 4.7; 95% CI = 2.0-11.6; P < .05). Younger-than-average nurses (< 27 years) were 4.5 times more likely to suffer NSI (OR = 4.5; 95% CI = 1.7-12.6; P < .05) and 3.1 times more likely to incur a syringe-needle injury (OR = 3.1; 95% CI = 1.4-7.0; P < .05). Working mixed shifts also increased the risk of any NSI (OR = 4.0; 95% CI = 1.7-10.4; P < .05) or syringe-needle NSI (OR = 4.4; 95% CI = 2.0-10.1; P < .05). Overall, our study suggests that NSI are common among Korean hospital nurses and represent a significant occupational burden for this large Asian demographic. Intervention and preventive strategies to help reduce their NSI exposures are urgently required in this country. Copyright © 2006 by Elsevier Inc.
SN - 8755-7223
AD - National Institute of Occupational Safety and Health, Kawasaki, Japan
U2 - PMID: 17141720.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Daly, Brian P.
AU - Burke, Robert
AU - Hare, Isadora
AU - Mills, Carrie
AU - Owens, Celeste
AU - Moore, Elizabeth
AU - Weist, Mark D.
T1 - Enhancing No Child Left Behind–School Mental Health Connections.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2006/11//
VL - 76
IS - 9
M3 - Article
SP - 446
EP - 451
PB - Wiley-Blackwell
SN - 00224391
AB - The No Child Left Behind Act of 2001 was signed into law by President George W. Bush in January 2002 and is regarded as the most significant federal education policy initiative in a generation. The primary focus of the No Child Left Behind Act is on promoting educational success for all children; however, the legislation also contains opportunities to advance school-based mental health. Unfortunately, the complexities of the provisions of the No Child Left Behind Act have made it difficult for educators, stakeholders, and mental health professionals to understand the legal and practical interface between No Child Left Behind and the school mental health movement. Therefore, the goals of this article are to (1) raise awareness about the challenges educators and school mental health professionals face as a result of the implementation of No Child Left Behind and (2) provide ideas and recommendations to advance the interface between No Child Left Behind and school mental health, which will support key provisions of the act and the growth of the field. (J Sch Health. 2006;76(9):446-451) [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of School Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EDUCATORS
KW - CHILDREN
KW - STUDENTS
KW - CHILD mental health
KW - LEGISLATION
KW - PRESIDENTS
KW - UNITED States
KW - UNITED States. No Child Left Behind Act of 2001
KW - BUSH, George W. (George Walker), 1946-
N1 - Accession Number: 22577618; Daly, Brian P. 1; Email Address: bdalyl@temple.edu Burke, Robert 2; Email Address: burkerw@muohio.edu Hare, Isadora 3; Email Address: ihare@hrsa.gov Mills, Carrie 4; Email Address: clmills@email.unc.edu Owens, Celeste 4; Email Address: cowens@psych.umaryland.edu Moore, Elizabeth 4; Email Address: emoore@psych.umaryland.edu Weist, Mark D. 5; Email Address: mweist@psych.umaryland.edu; Affiliation: 1: Post-Doctoral Fellow College of Health Professions, Temple University, 3307 North Broad St, 622-Jones Hall, Philadelphia, PA 19140 2: Assistant Professor, Education and Allied Professions, Miami University of Ohio, Teacher Education, McGujfey Hall, 401, Oxford, OH 45056 3: U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Office of Adolescent Health, 11509 Parkedge Drive, Rockville, M D 20852 4: Professor, Center for School Mental Health Analysis and Action, Department of Psychiatry, University of Maryland School of Medicine, 680 West Lexington St, 10th Floor, Baltimore, MD21201 5: Director, Center for School Mental Health Analysis and Action, and Professor, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard St, 4th Floor, Baltimore, MD 21201; Source Info: Nov2006, Vol. 76 Issue 9, p446; Subject Term: EDUCATORS; Subject Term: CHILDREN; Subject Term: STUDENTS; Subject Term: CHILD mental health; Subject Term: LEGISLATION; Subject Term: PRESIDENTS; Subject Term: UNITED States; Company/Entity: UNITED States. No Child Left Behind Act of 2001; People: BUSH, George W. (George Walker), 1946-; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 5141
L3 - 10.1111/j.1746-1561.2006.00142.x
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Help Prevent Exposure to Secondhand Smoke
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2006/11//
VL - 106
IS - 11
M3 - Editorial
SP - 1733
EP - 1733
SN - 00028223
N1 - Accession Number: 22995433; Moritsugu, Kenneth P. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Nov2006, Vol. 106 Issue 11, p1733; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2006.09.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106276043
T1 - From the Surgeon General. Help prevent exposure to secondhand smoke.
AU - Moritsugu KP
Y1 - 2006/11//
N1 - Accession Number: 106276043. Language: English. Entry Date: 20070504. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Passive Smoking -- Legislation and Jurisprudence -- United States
KW - Passive Smoking -- Prevention and Control
KW - Public Health
KW - Environmental Exposure -- Adverse Effects
KW - Environmental Exposure -- Prevention and Control
KW - Passive Smoking -- Adverse Effects
KW - United States
SP - 1733
EP - 1733
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 11
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Acting US Surgeon General, US Department of Health and Human Services
U2 - PMID: 17081817.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106272139
T1 - Trench fever: the British medical response in the Great War.
AU - Atenstaedt RL
Y1 - 2006/11//
N1 - Accession Number: 106272139. Language: English. Entry Date: 20070427. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 7802879.
KW - Gram-Negative Bacterial Infections -- History
KW - Military Personnel -- History
KW - War
KW - Gram-Negative Bacterial Infections -- Etiology
KW - Gram-Negative Bacterial Infections -- Therapy
KW - United Kingdom
SP - 564
EP - 568
JO - Journal of the Royal Society of Medicine
JF - Journal of the Royal Society of Medicine
JA - J R SOC MED
VL - 99
IS - 11
PB - Sage Publications, Ltd.
SN - 0141-0768
AD - National Public Health Service for Wales and Institute of Medical & Social Care Research (IMSCaR), University of Wales, Bangor, Wales, UK.
U2 - PMID: 17082300.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Min, Bok-Soon
AU - Noh, Yoon-Ju
AU - Shin, Jin-Ho
AU - Baek, Sun-Young
AU - Min, Kyung-Il
AU - Ryu, Seung-Rel
AU - Kim, Byoung-Guk
AU - Park, Mi-Kyung
AU - Choi, Seung-Eun
AU - Yang, Eun-Hee
AU - Park, Sue-Nie
AU - Hur, Sook-Jin
AU - Ahn, Byung-Yoon
T1 - Assessment of the quantitative real-time polymerase chain reaction using a cDNA standard for human group A rotavirus
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/11//
VL - 137
IS - 2
M3 - Article
SP - 280
EP - 286
SN - 01660934
AB - Abstract: Nucleic acid amplification techniques are used frequently for rapid diagnosis of viral diseases. In this study, a real-time polymerase chain reaction protocol that uses primers specific for the viral VP4 gene and the commercial SYBR Green reagent were evaluated for the quantitative measurement of human rotavirus (HRV) RNA in human stool specimens. SYBR Green I detection involved analysis of the melting temperature of the PCR product and measurement of fluorescence at the optimum temperature. The assay resulted in a sensitive and reproducible detection of targets ranging from low (<102 rotavirus cDNA copies/reaction) to high numbers (>106 rotavirus cDNA copies/reaction). No cross-reaction was found with crude cell culture stocks of coxsackievirus, echovirus, poliovirus, hepatitis A virus and adenovirus. Analysis with the HRV cDNA standard demonstrated high reproducibility with a coefficient of variation (CV) of 0.2–0.9%. Daily performance among three different laboratories showed a CV no greater than 8%, indicating an intermediate level of variation. These results demonstrate the feasibility of this method for quantitative analysis of human rotavirus in clinical samples. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - VIRAL hepatitis
KW - LIVER diseases
KW - CELL culture
KW - Human rotavirus
KW - Quantitative assay
KW - Real-time PCR
N1 - Accession Number: 22471983; Min, Bok-Soon 1,2 Noh, Yoon-Ju 1 Shin, Jin-Ho 3 Baek, Sun-Young 1 Min, Kyung-Il 1 Ryu, Seung-Rel 1 Kim, Byoung-Guk 1 Park, Mi-Kyung 1 Choi, Seung-Eun 1 Yang, Eun-Hee 1 Park, Sue-Nie 1 Hur, Sook-Jin 1 Ahn, Byung-Yoon 2; Email Address: ahnbyung@korea.ac.kr; Affiliation: 1: Department of Biologics Evaluation, Korea Food and Drug Administration, Republic of Korea 2: School of Life Sciences and Biotechnology, Korea University, 5-1, Anam-dong, Seoungbuk-gu, Seoul 136-701, Republic of Korea 3: Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland; Source Info: Nov2006, Vol. 137 Issue 2, p280; Subject Term: HEPATITIS A virus; Subject Term: VIRAL hepatitis; Subject Term: LIVER diseases; Subject Term: CELL culture; Author-Supplied Keyword: Human rotavirus; Author-Supplied Keyword: Quantitative assay; Author-Supplied Keyword: Real-time PCR; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.06.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Sherwin
AU - Wood, Owen
AU - Taffs, Rolf E.
AU - Hu, Jinjie
AU - Machuca, Ana
AU - Vallejo, Alejandro
AU - Hewlett, Indira
T1 - Development and evaluation of HIV-1 subtype RNA panels for the standardization of HIV-1 NAT assays
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2006/11//
VL - 137
IS - 2
M3 - Article
SP - 287
EP - 291
SN - 01660934
AB - Abstract: Multiple nucleic acid-based techniques (NAT) have been implemented for testing blood and plasma donors for HIV-1 RNA which may be detected at an earlier stage of infection when HIV antigen or antibody is absent or below the limit of detection of current assays. The available NAT assays are based on different technologies. In order to evaluate the performance of nucleic acid-based techniques (NAT assays) and to allow accurate comparisons of results from different assays, it is essential to have well characterized specimens with known copy numbers as a standard. For this purpose, a comprehensive study was conducted to develop two HIV-1 RNA reference panels. The first (Panel 1) was prepared using a single specimen from the HIV-1 group M subtype B and consists of panel members with a wide range of HIV-1 RNA copy numbers. Panel 2 consists of 26 members representing HIV-1 group M subtypes A, C, D, E, F, G and groups O and N. For accurate determination of HIV-1 RNA copy numbers of each member of Panel 2, they were analyzed using various testing platforms/technologies available through the cooperation of five independent laboratories participating in the study. A consensus value for HIV RNA copy number was assigned to each member of Panel 2 based on statistical analysis of the data provided by the participants. Both panels could serve as reference panels to be used by manufacturers of HIV NAT tests to evaluate the sensitivity limits of their assays. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - LENTIVIRUS diseases
KW - DISEASES
KW - RNA
KW - HIV-1 RNA
KW - International standard
KW - NAT
KW - Working reagents
N1 - Accession Number: 22471984; Lee, Sherwin 1 Wood, Owen 1 Taffs, Rolf E. 2 Hu, Jinjie 1 Machuca, Ana 1 Vallejo, Alejandro 1 Hewlett, Indira 1; Email Address: indira.hewlett@fda.hhs.gov; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US FDA, 1401 Rockville Pike (HFM-315), Rockville, MD 20852, United States 2: Laboratory of Bacterial, Parasitic and Unconventional Agents, United States; Source Info: Nov2006, Vol. 137 Issue 2, p287; Subject Term: HIV infections; Subject Term: LENTIVIRUS diseases; Subject Term: DISEASES; Subject Term: RNA; Author-Supplied Keyword: HIV-1 RNA; Author-Supplied Keyword: International standard; Author-Supplied Keyword: NAT; Author-Supplied Keyword: Working reagents; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parks, C. G.
AU - Cooper, G. S.
T1 - Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies.
JO - Lupus
JF - Lupus
Y1 - 2006/11//
VL - 15
IS - 11
M3 - Article
SP - 728
EP - 736
PB - Sage Publications Inc.
SN - 09612033
AB - Epidemiologic and experimental research suggests a potential role of occupational exposures in the development of systemic lupus erythematosus (SLE). A plausible association has been identified in studies of occupational silica exposure and SLE, complemented by experimental studies in lupus-prone mice exploring potential mechanisms related to apoptosis and immune dysregulation. Experimental studies of the solvent trichloroethylene in lupus-prone mice provide evidence of effects on immune function, including increased production of autoantibodies and activation of CD4 T cells. However, few studies of occupational solvent exposure and SLE have been conducted, and those that are available show little evidence of an association. There is some suggestion from the available studies of the potential influence of pesticides on SLE, but as with solvents, the specific type of pesticides that may be implicated is not known. Our understanding of the role of occupational exposures in SLE could be advanced by the development of larger, multisite or parallel studies that utilize similar questionnaire and exposure evaluation methods. Multiple studies using comparable exposure measures are needed to provide sufficient sample size for examining gene–environment interactions. We provide a general overview of data requirements and methods available for the assessment and evaluation of occupational exposures in clinical and populationbased studies of SLE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - INDUSTRIAL hygiene
KW - SILICA dust
KW - APOPTOSIS
KW - AUTOIMMUNE diseases
KW - TRICHLOROETHYLENE -- Physiological effect
KW - AUTOANTIBODIES -- Analysis
KW - GENOTYPE-environment interaction
KW - RISK factors
KW - GENETIC aspects
N1 - Accession Number: 23278580; Parks, C. G. 1; Email Address: cop8@cdc.gov Cooper, G. S. 2; Affiliation: 1: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV, USA. Tel: 919 541 2577 2: National Center for Environmental Assessment, U.S. Environmental Protection Agency, NW Washington, DC, USA; Source Info: 2006, Vol. 15 Issue 11, p728; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: INDUSTRIAL hygiene; Subject Term: SILICA dust; Subject Term: APOPTOSIS; Subject Term: AUTOIMMUNE diseases; Subject Term: TRICHLOROETHYLENE -- Physiological effect; Subject Term: AUTOANTIBODIES -- Analysis; Subject Term: GENOTYPE-environment interaction; Subject Term: RISK factors; Subject Term: GENETIC aspects; Number of Pages: 9p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1177/0961203306069346
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Puryear, Michele
AU - Weissman, Gloria
AU - Watson, Michael
AU - Mann, Marie
AU - Strickland, Bonnie
AU - van Dyck, Peter C.
T1 - The regional genetic and newborn screening service collaboratives: The first two years.
JO - Mental Retardation & Developmental Disabilities Research Reviews
JF - Mental Retardation & Developmental Disabilities Research Reviews
Y1 - 2006/11//
VL - 12
IS - 4
M3 - Article
SP - 288
EP - 292
PB - John Wiley & Sons, Inc.
SN - 10804013
AB - Newborn screening and genetic technologies are expanding and changing rapidly, increasing the demand for genetic specialty services. Because of the scarcity and geographic maldistribution of genetic specialty services, access to these services is a critical issue. This article discusses some of the efforts initiated by the Maternal and Child Health Bureau of the Health Resources and Services Administration, particularly the establishment of regional genetic and newborn screening collaboratives to improve access to these services and expertise. MRDD Research Reviews 2006;12:288–292. Published 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEWBORN infants -- Diseases
KW - DIAGNOSIS
KW - MEDICAL screening
KW - GENETICS
KW - CHILD health services
KW - MATERNAL health services
KW - collaboratives
KW - genetic
KW - newborn
KW - regional
KW - screening
KW - services
N1 - Accession Number: 23527462; Puryear, Michele 1; Email Address: mpuryear@hrsa.gov Weissman, Gloria 2 Watson, Michael 2 Mann, Marie 1 Strickland, Bonnie 1 van Dyck, Peter C. 1; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Department of Health and Human Services, Rockville, Maryland 2: American College of Medical Genetics, 9650 Rockville Pike, Bethesda, Maryland; Source Info: 2006, Vol. 12 Issue 4, p288; Subject Term: NEWBORN infants -- Diseases; Subject Term: DIAGNOSIS; Subject Term: MEDICAL screening; Subject Term: GENETICS; Subject Term: CHILD health services; Subject Term: MATERNAL health services; Author-Supplied Keyword: collaboratives; Author-Supplied Keyword: genetic; Author-Supplied Keyword: newborn; Author-Supplied Keyword: regional; Author-Supplied Keyword: screening; Author-Supplied Keyword: services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1002/mrdd.20121
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McKinzie, Page B.
AU - Delongchamp, Robert R.
AU - Tao Chen
AU - Parsons, Barbara L.
T1 - ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue® rats treated with N-hydroxy-2-acetylaminofluorene.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2006/11//
VL - 21
IS - 6
M3 - Article
SP - 391
EP - 397
PB - Oxford University Press / USA
SN - 02678357
AB - K-ras codon 12 GGT→GAT and GGT→GTT mutations are the most frequently observed K-ras point mutations in human and rodent tumors and therefore are implicated in carcinogenesis for many tissues. Measurement of these mutations in rat models and human tissue could facilitate a more logical extrapolation of rodent tumorigenesis data to human disease. We have developed allele-specific competitive blocker PCR (ACB-PCR) assays for rat K-ras codon 12 GGT→GTT and GGT→GAT mutations that parallel the already published assays for human K-ras codon 12 mutations. Liver K-ras codon 12 mutant allele fractions were measured in vehicle-treated and N-hydroxy-2-acetylaminofluorene (N-OH-AAF)-treated Big Blue® rats. The average K-ras codon 12 GGT→GTT mutant fraction (MF) for four control rats was 50 × 10−6 (95% CI: 27 × 10−6, 95 × 10−6) and for four treated rats was 165 × 10−6 (95% CI: 87 × 10−6, 312 × 10−6), indicating a 3.3-fold increase with treatment (95% CI: 1.3–8.1). The average MF of K-ras codon 12 GGT→GAT for control rats was 1320 × 10−6 (95% CI: 498 × 10−6, 3500 × 10−6) and for treated rats was 8450 × 10−6 (95% CI: 3180 × 10−6, 22 400 × 10−6), indicating a 6.4-fold increase with treatment (95% CI: 1.6–25.4). These transgenic rats were part of a study that included analysis of liver lacI mutations. Although data from lacI determinations show that this compound induces mostly G→T mutations, using the ACB-PCR method both K-ras codon 12 GGT→GTT and GGT→GAT MFs were significantly increased in treated rats versus control rats. This data raises the possibility that N-OH-AAF may not only induce mutations by a genotoxic mechanism, but also by amplification of both de novo and pre-existing K-ras mutation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acetylaminofluorene
KW - Carcinogenesis
KW - Mutagenicity testing
KW - Liver -- Abnormalities
KW - Rats as laboratory animals
KW - Mutagenesis
N1 - Accession Number: 22952452; McKinzie, Page B. 1; Email Address: page.mckinzie@fda.hhs.gov; Delongchamp, Robert R. 2; Tao Chen 1; Parsons, Barbara L. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology HFT-120 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Nov2006, Vol. 21 Issue 6, p391; Thesaurus Term: Acetylaminofluorene; Thesaurus Term: Carcinogenesis; Thesaurus Term: Mutagenicity testing; Subject Term: Liver -- Abnormalities; Subject Term: Rats as laboratory animals; Subject Term: Mutagenesis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/mutage/gel041
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Garey, J.
AU - Ferguson, S.A.
AU - Paule, M.G.
T1 - Effects of chronic low-dose acrylamide exposure on progressive ratio performance in rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2006/11//
VL - 28
IS - 6
M3 - Abstract
SP - 708
EP - 708
SN - 08920362
N1 - Accession Number: 23280469; Garey, J. 1 Ferguson, S.A. 1 Paule, M.G. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA; Source Info: Nov2006, Vol. 28 Issue 6, p708; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2006.09.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23280469&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Dimova, J.G.
AU - Chelonis, J.J.
AU - Paule, M.G.
T1 - BTS Student Travel Award Winner Effects of prenatal cocaine exposure in DMTS task reversal on monkeys
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2006/11//
VL - 28
IS - 6
M3 - Abstract
SP - 711
EP - 711
SN - 08920362
N1 - Accession Number: 23280476; Dimova, J.G. 1 Chelonis, J.J. 1 Paule, M.G. 2; Affiliation: 1: State University of New York, College at Brockport, USA 2: National Center for Toxicological Research, USA; Source Info: Nov2006, Vol. 28 Issue 6, p711; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2006.09.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lange, Susan
AU - Quynh Nhu Nguyen
T1 - Cables and electrodes can burn patients during MRI.
JO - Nursing
JF - Nursing
Y1 - 2006/11//
VL - 36
IS - 11
M3 - Article
SP - 18
EP - 18
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article discusses the precautions to be taken to avoid skin burns on patients undergoing magnetic resonance imaging (MRI). ECG electrodes attached to cables are worn by the patients during an MRI. Before the imaging study, cables and electrodes should be cleaned and their expiry date should be used within their expiry date. The possibility of burns from leftover electrodes could be avoided by searching for them on and around the patient.
KW - ELECTRICAL burns
KW - PREVENTION
KW - MAGNETIC resonance imaging
KW - ELECTRICAL injuries
KW - SKIN -- Wounds & injuries
KW - BURNS & scalds
KW - DIAGNOSTIC imaging
N1 - Accession Number: 22924127; Lange, Susan 1 Quynh Nhu Nguyen 2; Affiliation: 1: Medical imaging specialist, Center for Devices and Radiological Health. 2: Biomedical engineer fellow, Center for Devices and Radiological Health.; Source Info: Nov2006, Vol. 36 Issue 11, p18; Subject Term: ELECTRICAL burns; Subject Term: PREVENTION; Subject Term: MAGNETIC resonance imaging; Subject Term: ELECTRICAL injuries; Subject Term: SKIN -- Wounds & injuries; Subject Term: BURNS & scalds; Subject Term: DIAGNOSTIC imaging; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106216698
T1 - Device safety. Cables and electrodes can burn patients during MRI.
AU - Lange S
AU - Nguyen QN
Y1 - 2006/11//
N1 - Accession Number: 106216698. Language: English. Entry Date: 20070119. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Burns -- Etiology
KW - Electrodes -- Adverse Effects
KW - Equipment Safety
KW - Magnetic Resonance Imaging -- Adverse Effects
KW - Electrocardiography
SP - 18
EP - 18
JO - Nursing
JF - Nursing
JA - NURSING
VL - 36
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Medical Imaging Specialist, Center for Devices and Radiological Health
U2 - PMID: 17079897.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hillburn, Kathy
AU - McNulty, Julie
AU - Jewett, Lorraine
AU - Wainwright, Karen
T1 - Build upon strengths and leadership practices using EBP.
JO - Nursing Management
JF - Nursing Management
Y1 - 2006/11//
VL - 37
IS - 11
M3 - Article
SP - 15
EP - 16
PB - Lippincott Williams & Wilkins
SN - 07446314
AB - The article discusses how to build strengths and leadership practices by using evidence-based practice (EPB). It talks about the Alaska Native Medical Center (ANMC), a healthcare system, which is managed by two tribal organization, that reaches geographically remote rural villages within a frontier state that is one third the size of the U.S. ANMC offers EBP conference for nurses, nursing grand rounds, staff nurse internship, an educational series for nurse managers and a Web-based journal club.
KW - PROFESSIONAL practice
KW - PROFESSIONAL relationships
KW - NURSES
KW - MEDICAL centers
KW - UNITED States
N1 - Accession Number: 22927313; Hillburn, Kathy 1 McNulty, Julie 2 Jewett, Lorraine 3,4 Wainwright, Karen 5; Affiliation: 1: Chief nurse executive, Nursing Research and Evidence-Based Practice Council 2: Nursing internship coordinator and Magnet project director co-chair, Nursing Research and Evidence-Based Practice Council 3: Manager, Organizational Learning/Hospital Education, Department of Organizational Development and Clinical Excellence 4: Co-chair, Nursing Research and Evidence-Based Practice Council, of Alaska Native Medical Center, Anchorage, Ala. 5: Administrator of Rapid City Public Health Service, Sioux San Indian Hospital, Rapid City, S.D.; Source Info: Nov2006, Vol. 37 Issue 11, p15; Subject Term: PROFESSIONAL practice; Subject Term: PROFESSIONAL relationships; Subject Term: NURSES; Subject Term: MEDICAL centers; Subject Term: UNITED States; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621491 HMO Medical Centers; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Junod, Suzanne White
T1 - James Harvey Young.
JO - OAH Newsletter
JF - OAH Newsletter
Y1 - 2006/11//
VL - 34
IS - 4
M3 - Obituary
SP - 23
EP - 23
PB - Organization of American Historians
SN - 10591125
AB - This article presents an obituary for James Harvey Young, the Candler Professor Emeritus at Emory University.
KW - YOUNG, James Harvey
N1 - Accession Number: 23316326; Junod, Suzanne White 1; Affiliation: 1: U.S. Food and Drug Administration; Source Info: Nov2006, Vol. 34 Issue 4, p23; People: YOUNG, James Harvey; Number of Pages: 1/3p; Document Type: Obituary
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106231922
T1 - NIOSH research efforts to prevent musculoskeletal disorders in the healthcare industry.
AU - Waters T
AU - Collins J
AU - Galinsky T
AU - Caruso C
Y1 - 2006/11//Nov/Dec2006
N1 - Accession Number: 106231922. Language: English. Entry Date: 20070209. Revision Date: 20150819. Publication Type: Journal Article; review; statistics; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8409486.
KW - Musculoskeletal System -- Injuries
KW - Occupational-Related Injuries -- Prevention and Control
KW - Accidental Falls -- Etiology
KW - Accidental Falls -- Prevention and Control
KW - Education, Nursing
KW - Health Personnel -- Education
KW - Home Health Care
KW - Hospitals
KW - Lifting and Transfer Equipment -- Evaluation
KW - Lifting -- Education
KW - National Institute for Occupational Safety and Health
KW - Nursing Homes
KW - Occupational-Related Injuries -- Classification
KW - Operating Rooms
KW - Patient Positioning
KW - Personnel Staffing and Scheduling
KW - Research
SP - 380
EP - 389
JO - Orthopaedic Nursing
JF - Orthopaedic Nursing
JA - ORTHOP NURS
VL - 25
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Healthcare workers, including orthopaedic nurses, face a number of risk factors in the workplace for musculoskeletal disorders such as back and shoulder injuries. These disorders are associated with excessive back and shoulder loading due to manual patient handling, applying excessive forces during pushing and/or pulling of objects, required use of awkward postures during patient care, and working long hours and shiftwork. No healthcare workers are immune from injury because workers in all clinical areas are exposed to occupational risk factors, including hospitals, nursing homes, emergency services, critical care, operating rooms, orthopaedic units, and home healthcare environments. This article includes a summary of the scientific efforts of the researchers and their partners at the National Institute for Occupational Safety and Health (NIOSH) in evaluating and developing the best practice recommendations for reducing risk of these disorders for exposed workers. The studies conducted by NIOSH researchers and their partners approach the problem from a variety of perspectives, ranging from comprehensive epidemiological studies examining the effectiveness of implementation of a safe patient handling and movement program to laboratory studies evaluating the biomechanical stress associated with using patient handling equipment, and education training programs for use in schools of nursing to educate new workers about safe work practices. Results of these studies have provided scientific evidence that significant occupational risks for musculoskeletal disorders exist and that effective interventions are available to reduce the risk for these workers.
SN - 0744-6020
AD - Division of Applied Reseatch and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 17130760.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Holman, Robert C.
AU - Stoll, Barbara J.
AU - Curns, Aaron T.
AU - Yorita, Krista L.
AU - Steiner, Claudia A.
AU - Schonberger, Lawrence B.
T1 - Necrotising enterocolitis hospitalisations among neonates in the United States.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2006/11//
VL - 20
IS - 6
M3 - Article
SP - 498
EP - 506
PB - Wiley-Blackwell
SN - 02695022
AB - The objective of this study was to estimate the rate and describe the epidemiology of necrotising enterocolitis (NEC) among neonates (infants <1 month of age) hospitalised in the United States. Hospital discharge records for neonates with an NEC diagnosis and an in-hospital death or routine discharge were selected for analysis from the 2000 Kids’ Inpatient Database. An estimated 4463 (SE = 219) hospitalisations associated with NEC occurred among neonates in the United States during the year 2000, resulting in a hospitalisation rate of 109.9 [95% CI 97.2, 122.6] per 100 000 livebirths. The rate of NEC hospitalisations was highest among non-Hispanic Black neonates. The median hospital length of stay was 49 days. The in-hospital fatality rate was 15.2% (SE = 1.0%). Neonates who underwent a surgical procedure during hospitalisation were more likely to have a longer length of stay and to die than were those who did not have surgical intervention. Low-birthweight (LBW) neonates with NEC were more likely than LBW neonates hospitalised with other diagnoses to be very LBW (VLBW), non-Hispanic Black and male. In addition, compared with LBW neonates hospitalised with other diagnoses, LBW neonates with NEC had higher hospital charges and longer lengths of stay, and were more likely to die during hospitalisation. This study provides the first national estimate of the rate of hospitalisation for NEC among neonates in the United States. During 2000, there was one NEC hospitalisation per 1000 livebirths, with approximately 1 in 7 NEC hospitalisations ending in death. NEC accounts for substantial morbidity; thus, the development of prevention strategies and effective therapies continues to be an important issue. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEONATAL necrotizing enterocolitis
KW - NEWBORN infants
KW - HOSPITAL care
KW - LOW birth weight
KW - EPIDEMIOLOGY
KW - INFANT mortality
KW - SURGERY
KW - RISK factors
KW - UNITED States
KW - ethnic group
KW - hospital length of stay
KW - mortality
KW - necrotising enterocolitis
N1 - Accession Number: 22724287; Holman, Robert C. 1 Stoll, Barbara J. 2 Curns, Aaron T. 1 Yorita, Krista L. 1 Steiner, Claudia A. 3 Schonberger, Lawrence B. 1; Affiliation: 1: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 2: Emory University School of Medicine, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Atlanta, GA 3: Healthcare Cost and Utilization Project, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, Rockville, MD, USA; Source Info: Nov2006, Vol. 20 Issue 6, p498; Subject Term: NEONATAL necrotizing enterocolitis; Subject Term: NEWBORN infants; Subject Term: HOSPITAL care; Subject Term: LOW birth weight; Subject Term: EPIDEMIOLOGY; Subject Term: INFANT mortality; Subject Term: SURGERY; Subject Term: RISK factors; Subject Term: UNITED States; Author-Supplied Keyword: ethnic group; Author-Supplied Keyword: hospital length of stay; Author-Supplied Keyword: mortality; Author-Supplied Keyword: necrotising enterocolitis; Number of Pages: 9p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-3016.2006.00756.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Secor, W. E.
T1 - Interactions between schistosomiasis and infection with HIV-1.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2006/11//
VL - 28
IS - 11
M3 - Article
SP - 597
EP - 603
PB - Wiley-Blackwell
SN - 01419838
AB - In many regions of the world, both schistosomiasis and HIV/AIDS are endemic, resulting in patients harbouring co-infections. Because interaction with host CD4 + T cells is a characteristic of schistosome as well as HIV-1 infections, bi-directional disease effects may be sufficiently different from sequelae caused by either infectious agent alone to warrant alteration of public health approaches in areas of co-endemnicity. Studies published over the past decade provide useful insights into interactions between schistosomiasis and infection with HIV-1, and overall support the hypothesis that special emphasis on treatment of schistosomiasis in populations with elevated prevalence or risk of HIV-1 infection is justified. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasite Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHISTOSOMIASIS
KW - IMMUNE response
KW - RHESUS monkey
KW - DRUG therapy
KW - HEPATOTOXICOLOGY
KW - co-infection
KW - HIV-1
KW - schistosomiasis
N1 - Accession Number: 22706599; Secor, W. E. 1; Email Address: was4@cdc.gov; Affiliation: 1: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA; Source Info: Nov2006, Vol. 28 Issue 11, p597; Subject Term: SCHISTOSOMIASIS; Subject Term: IMMUNE response; Subject Term: RHESUS monkey; Subject Term: DRUG therapy; Subject Term: HEPATOTOXICOLOGY; Author-Supplied Keyword: co-infection; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: schistosomiasis; Number of Pages: 7p; Document Type: Article
L3 - 10.1111/j.1365-3024.2006.00887.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Amy
AU - Lowe, Elizabeth
AU - Zimmerman, Beth
AU - Crall, James
AU - Foley, Mary
AU - Nehring, Mark
T1 - Preventing Early Childhood Caries: Lessons from the Field.
JO - Pediatric Dentistry
JF - Pediatric Dentistry
Y1 - 2006/11//Nov/Dec2006
VL - 28
IS - 6
M3 - Article
SP - 553
EP - 560
SN - 01641263
AB - Early childhood caries (ECC) is a significant public health concern affecting millions of high-risk families with young children. The purpose of this article is to present the proceedings from a May 2005 national forum, convened in Washington, DC, by the Maternal and Child Health Bureau of the Health Resources and Services Administration, which brought together representatives of 14 ECC programs from around the United States to share experiences and help inform future efforts to prevent and reduce ECC. Conclusions drawn from the presentations representing public, private, and academic sectors include: (1) oral health is an integral part of overall health and impacts quality of life and health outcomes; (2) oral health should be integrated into broader child health and development systems; (3) dental caries should be addressed through a chronic disease management model; (4) comprehensive approaches incorporating multiple strategies that involve families, clinicians, and child services providers in ECC prevention and reduction efforts should be employed. Lessons learned from existing ECC programs-summaries of which are included in the article-provide valuable insight into a number of core principles for preventing ECC. Findings from this workshop constitute a knowledge base that can help improve and strengthen ECC programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Dentistry is the property of American Society of Dentistry for Children and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK assessment
KW - PUBLIC health
KW - DENTAL caries -- Prevention
KW - HEALTH services administration
KW - MEDICAL personnel
KW - UNITED States
KW - CHILDREN
KW - EARLY CHILDHOOD CARIES
KW - ORAL HEALTH
KW - PREVENTION
N1 - Accession Number: 23769864; Brown, Amy 1 Lowe, Elizabeth 2 Zimmerman, Beth 3; Email Address: bzimmerman@hsrnet.com Crall, James 4,5 Foley, Mary 6 Nehring, Mark 7; Affiliation: 1: Policy Associate, Health Systems Research, Inc., Washington, DC 2: Project Manager, Health Systems Research, Inc., Washington, DC 3: Director, Health Promotion Division, Health Systems Research, Inc., Washington, DC 4: Professor, Department of Pediatric Dentistry, School of Dentistry, University of California, Los Angeles, Calif. 5: Director, National Oral Health Policy Center, Department of Pediatric Dentistry, School of Dentistry, University of California, Los Angeles, Calif. 6: Project Director, Perinatal and Infant Oral Health, Children's Dental Health Project, Washington, DC 7: Chief Dental Officer, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md.; Source Info: Nov/Dec2006, Vol. 28 Issue 6, p553; Subject Term: RISK assessment; Subject Term: PUBLIC health; Subject Term: DENTAL caries -- Prevention; Subject Term: HEALTH services administration; Subject Term: MEDICAL personnel; Subject Term: UNITED States; Author-Supplied Keyword: CHILDREN; Author-Supplied Keyword: EARLY CHILDHOOD CARIES; Author-Supplied Keyword: ORAL HEALTH; Author-Supplied Keyword: PREVENTION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zaloshnja, Eduard
AU - Miller, Ted
AU - Jones, Paul
AU - Litovitz, Toby
AU - Coben, Jeffrey
AU - Steiner, Claudia
AU - Sheppard, Monique
T1 - The Potential Impact of Poison Control Centers on Rural Hospitalization Rates for Poisoning.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/11//
VL - 118
IS - 5
M3 - Article
SP - 2094
EP - 2100
SN - 00314005
AB - OBJECTIVE. This study tested the hypothesis that underutilization of poison control centers is associated with increased rates of hospitalizations attributable to poisonings in rural areas. METHODS. To measure the potential impact of poison control centers on hospitalization rates in rural areas among people who visit emergency departments because of poisoning, we estimated the reduction in hospitalization rates associated with increased rates of calls to centers. We used the 2003 State Inpatient Database and State Emergency Department Database from the Healthcare Cost and Utilization Project to calculate the numbers of emergency department visits and hospitalizations for each county in the 12 states analyzed. We used Toxic Exposure Surveillance System data from the American Association of Poison Control Centers to calculate the number of human exposure calls per capita according to county. RESULTS. In rural counties, a 1% higher poison control center human poison exposure call rate was associated with a 0.19% lower hospitalization rate among people who visited emergency departments because of poisoning. If the observed association is causative, then 43.3 calls would prevent 1 hospital admission, yielding $7321 in net cost savings and a return on investment of 5.9:1 (from the health care system perspective). CONCLUSIONS. Our results establish the existence of the hypothesized association between rural poison control center utilization rates and hospitalization rates among emergency department-treated poisoning patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UTILIZATION review (Medical care)
KW - POISON control centers
KW - HOSPITAL care
KW - RURAL geography
KW - EMERGENCY medical services
KW - benefit
KW - cost-effectiveness
KW - hospitalization rate
KW - poison control center
KW - poisoning
KW - rural
N1 - Accession Number: 23247477; Zaloshnja, Eduard 1; Email Address: zaloshnja@pire.org Miller, Ted 1 Jones, Paul 1 Litovitz, Toby 2 Coben, Jeffrey 3 Steiner, Claudia 4 Sheppard, Monique 1; Affiliation: 1: Pacific Institute for Research and Evaluation, Calverton, Maryland 2: National Capital Poison Center, Washington, DC 3: Injury Control Research Center, West Virginia University, Morgantown, West Virginia 4: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Nov2006, Vol. 118 Issue 5, p2094; Subject Term: UTILIZATION review (Medical care); Subject Term: POISON control centers; Subject Term: HOSPITAL care; Subject Term: RURAL geography; Subject Term: EMERGENCY medical services; Author-Supplied Keyword: benefit; Author-Supplied Keyword: cost-effectiveness; Author-Supplied Keyword: hospitalization rate; Author-Supplied Keyword: poison control center; Author-Supplied Keyword: poisoning; Author-Supplied Keyword: rural; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 913130 Municipal police services; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2006-1585
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hinman, L. M.
AU - Huang, S.-M.
AU - Hackett, J.
AU - Koch, W. H.
AU - Love, P. Y.
AU - Pennello, G.
AU - Torres-Cabassa, A.
AU - Webster, C.
T1 - The drug diagnostic co-development concept paper Commentary from the 3rd FDA-DIA-PWG-PhRMA-BIO Pharmacogenomics Workshop.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2006/11//
VL - 6
IS - 6
M3 - Article
SP - 375
EP - 380
PB - Nature Publishing Group
SN - 1470269X
AB - At the Washington DC Pharmacogenomics in Drug Development and Regulatory Decision-Making: Workshop III – Three Years of Promise, Proposals and Progress on Optimizing the Benefit/Risk of Medicines (11–13 April 2005), one break-out session (Track 2) focused on co-development of therapeutic drug and diagnostic products. The Food and Drug Administration (FDA) released a draft concept paper shortly before the workshop was to convene. Track 2 was a forum for initial discussion of the content of the concept paper, and industry's initial reactions. After the workshop, formal commentaries on the co-development concept paper were submitted by several trade associations (e.g., Pharmaceutical Research and Manufacturers of America (PhRMA), Advanced Medical Technology Association (AdvaMed), American Association for Clinical Chemistry) and individual companies to FDA's Docket No. 2004N-0279. This paper includes a summary of the key features of the draft concept paper, the discussion in Track 2 of the April, 2005 meeting and highlights of the industry comments submitted to the FDA docket following the meeting.The Pharmacogenomics Journal (2006) 6, 375–380. doi:10.1038/sj.tpj.6500392; published online 2 May 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenomics Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - DRUG development
KW - MEDICAL care
KW - BIOCHEMISTRY
KW - PHARMACEUTICAL industry
KW - drug/diagnostic co-development
KW - pharmacogenetics
N1 - Accession Number: 23211131; Hinman, L. M. 1; Email Address: lois.hinman@roche.com Huang, S.-M. 2 Hackett, J. 3 Koch, W. H. 4 Love, P. Y. 5 Pennello, G. 6 Torres-Cabassa, A. 5 Webster, C. 7; Affiliation: 1: Hoffmann-La Roche Inc., Nutley, NJ, USA 2: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, MD, USA 3: Office of In Vitro Device Evaluation and Safety, Center for Devices and Radiological Health (CDRH), FDA, Rockville, MD, USA 4: Roche Molecular Systems, Pleasanton, CA, USA 5: Office of Combination Products, Office of the Commissioner, FDA, Rockville, MD, USA 6: Diagnostics Branch, Division of Biostatisics, CDRH, FDA, Rockville, MD, USA 7: Millenium Pharmaceuticals Inc., Cambridge, MA, USA; Source Info: 2006, Vol. 6 Issue 6, p375; Subject Term: PHARMACOGENOMICS; Subject Term: DRUG development; Subject Term: MEDICAL care; Subject Term: BIOCHEMISTRY; Subject Term: PHARMACEUTICAL industry; Author-Supplied Keyword: drug/diagnostic co-development; Author-Supplied Keyword: pharmacogenetics; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1038/sj.tpj.6500392
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106269876
T1 - Within-state availability of transition-to-adulthood services for youths with serious mental health conditions.
AU - Davis M
AU - Geller JL
AU - Hunt B
Y1 - 2006/11//
N1 - Accession Number: 106269876. Language: English. Entry Date: 20070420. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. NLM UID: 9502838.
KW - Adolescent Health Services
KW - Child Health Services
KW - Community Mental Health Services
KW - Continuity of Patient Care
KW - Health Services Accessibility
KW - Mental Disorders -- Rehabilitation
KW - Support, Psychosocial
KW - Transitional Programs
KW - Adolescence
KW - Adolescent Health Services -- Administration
KW - Adult
KW - Child
KW - Child Health Services -- Administration
KW - Descriptive Research
KW - Descriptive Statistics
KW - Diagnosis, Dual (Psychiatry)
KW - Funding Source
KW - Mental Disorders -- Epidemiology
KW - Questionnaires
KW - Semi-Structured Interview
KW - Severity of Illness Indices
KW - Substance Use Disorders -- Rehabilitation
KW - United States
KW - Vocational Guidance
KW - Human
SP - 1594
EP - 1599
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 57
IS - 11
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: This study describes the existence and nature of services within state child and adult mental health systems that support the transition from adolescence to adulthood. METHODS: State child and adult mental health administrators from all but one state were interviewed by telephone with a semistructured questionnaire regarding transition services in their state mental health system, such as supported housing, vocational support, preparation for independent living, and dual diagnosis treatment. Eight states were deemed sufficiently decentralized to render state-level administrator reports invalid. Specific service data from the remaining 41 states and the District of Columbia were analyzed with descriptive statistics. RESULTS: One-quarter of child state mental health systems and one-half of adult state mental health systems offered no transition services, and few provided any kind of transition service at more than one site. Most types of transition services were available at all in less than 20 percent of the states. CONCLUSIONS: Across the United States transition support services are lacking. The adult system in particular will require major transformation to provide the service capacity that is needed to meet the current standards of transition service accessibility for young Americans with serious mental health conditions.
SN - 1075-2730
AD - Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. maryann.davis@umassmed.edu
U2 - PMID: 17085607.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kitt, Margaret M.
AU - Khalid, Gulmakai
AU - Rahimi, Shakira
AU - McCarthy, Bria J.
T1 - An Occupational Health Services Initiative at a Women's Hospital in Kabul, Afghanistan.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2006/11//Nov/Dec2006
VL - 121
IS - 6
M3 - Article
SP - 650
EP - 657
SN - 00333549
AB - This article describes the process of developing targeted occupational health services for the health care workers in a women's hospital in Kabul, Afghanistan, as part of a larger project to establish an obstetrics and gynecology residency training program at the facility. The goal was to create a feasible and sustainable program to: (1) address basic health care needs impacting the ability of these Afghan health care workers to optimize learning opportunities; (2) decrease absenteeism due to illness; (3) decrease the likelihood of infectious disease transmission among staff, from staff to patients, and from patients to staff; (4) foster belief that a healthy and safe working environment is a basic right; (5) begin to collect preliminary health status indicators on health care workers in this employee population; and (6) serve as an adaptable program to expand to other Afghan health care workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL health services
KW - WOMEN'S hospitals
KW - WOMEN'S health services
KW - KABUL (Afghanistan)
KW - AFGHANISTAN
N1 - Accession Number: 22860200; Kitt, Margaret M. 1; Email Address: ajy8@cdc.gov Khalid, Gulmakai 2 Rahimi, Shakira 2 McCarthy, Bria J. 2; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 2: WHO Collaborating Center in Reproductive Health, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA; Source Info: Nov/Dec2006, Vol. 121 Issue 6, p650; Subject Term: OCCUPATIONAL health services; Subject Term: WOMEN'S hospitals; Subject Term: WOMEN'S health services; Subject Term: KABUL (Afghanistan); Subject Term: AFGHANISTAN; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - M. Smith, Nicole
AU - Lee, Robin
AU - Heitkemper, Douglas T.
AU - DeNicola Cafferky, Katie
AU - Haque, Abidul
AU - Henderson, Alden K.
T1 - Inorganic arsenic in cooked rice and vegetables from Bangladeshi households
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2006/11//
VL - 370
IS - 2/3
M3 - Article
SP - 294
EP - 301
SN - 00489697
AB - Abstract: Many Bangladeshi suffer from arsenic-related health concerns. Most mitigation activities focus on identifying contaminated wells and reducing the amount of arsenic ingested from well water. Food as a source of arsenic exposure has been recently documented. The objectives of this study were to measure the main types of arsenic in commonly consumed foods in Bangladesh and estimate the average daily intake (ADI) of arsenic from food and water. Total, organic and inorganic, arsenic were measured in drinking water and in cooked rice and vegetables from Bangladeshi households. The mean total arsenic level in 46 rice samples was 358 μg/kg (range: 46 to 1110 μg/kg dry weight) and 333 μg/kg (range: 19 to 2334 μg/kg dry weight) in 39 vegetable samples. Inorganic arsenic calculated as arsenite and arsenate made up 87% of the total arsenic measured in rice, and 96% of the total arsenic in vegetables. Total arsenic in water ranged from 200 to 500 μg/L. Using individual, self-reported data on daily consumption of rice and drinking water the total arsenic ADI was 1176 μg (range: 419 to 2053 μg), 14% attributable to inorganic arsenic in cooked rice. The ADI is a conservative estimate; vegetable arsenic was not included due to limitations in self-reported daily consumption amounts. Given the arsenic levels measured in food and water and consumption of these items, cooked rice and vegetables are a substantial exposure pathway for inorganic arsenic. Intervention strategies must consider all sources of dietary arsenic intake. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE element minerals
KW - NONMETALS
KW - DRINKING water
KW - FRESH water
KW - Arsenate
KW - Arsenite
KW - Average daily intake
KW - Bangladesh
KW - Dimethylarsinic acid
KW - Food
N1 - Accession Number: 22635060; M. Smith, Nicole 1 Lee, Robin 2 Heitkemper, Douglas T. 3 DeNicola Cafferky, Katie 3,4 Haque, Abidul 5 Henderson, Alden K. 2; Email Address: AHenderson@cdc.gov; Affiliation: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States 2: Division of Health Studies, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, Atlanta, GA 30333, United States 3: Forensic Chemistry Center, U.S. Food and Drug Administration, 6751 Steger Drive Cincinnati, OH 45237, United States 4: Oak Ridge Associated Universities Research Fellow, United States 5: National Institute of Preventive and Social Medicine, Mohakhali, Dhaka-1212, Bangladesh; Source Info: Nov2006, Vol. 370 Issue 2/3, p294; Subject Term: NATIVE element minerals; Subject Term: NONMETALS; Subject Term: DRINKING water; Subject Term: FRESH water; Author-Supplied Keyword: Arsenate; Author-Supplied Keyword: Arsenite; Author-Supplied Keyword: Average daily intake; Author-Supplied Keyword: Bangladesh; Author-Supplied Keyword: Dimethylarsinic acid; Author-Supplied Keyword: Food; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.scitotenv.2006.06.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106280857
T1 - Non-fatal occupational injury among active and passive smokers in small- and medium-scale manufacturing enterprises in Japan.
AU - Nakata A
AU - Ikeda T
AU - Takahashi M
AU - Haratani T
AU - Hojou M
AU - Fujioka Y
AU - Araki S
Y1 - 2006/11//
N1 - Accession Number: 106280857. Language: English. Entry Date: 20070511. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Grant Information: Supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC and in part by the Japanese Ministry of Education, Culture, Sports, Science and Technology. NLM UID: 8303205.
KW - Accidents, Occupational -- Risk Factors
KW - Japanese
KW - Passive Smoking
KW - Smoking
KW - Adolescence
KW - Adult
KW - Cross Sectional Studies
KW - Employee Attitudes
KW - Female
KW - Funding Source
KW - Industry
KW - Japan
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Human
SP - 2452
EP - 2463
JO - Social Science & Medicine
JF - Social Science & Medicine
JA - SOC SCI MED
VL - 63
IS - 9
PB - Pergamon Press - An Imprint of Elsevier Science
AB - Active smoking is a risk factor for occupational injury, whereas its association with passive smoking is unknown. To evaluate the contribution of active and passive smoking to non-fatal occupational injury in manufacturing sectors, 2302 randomly selected workers aged 16-83 years working in 244 small- and medium-scale enterprises in Yashio city, Japan, were surveyed by means of a self-administered questionnaire. Smoking history, exposure to passive smoking, and occupational injury were evaluated by self-report. Exposure levels to passive smoking were assessed separately at work and at home as never, occasional, or regular exposure. Overall, 61.4% of men and 22.3% of women were current smokers. Among never smokers, 62.2% of men and 68.6% of women reported exposure to passive smoking either at work or home. Prevalence of occupational injuries was 36.2% for never, 43.3% for former, and 41.2% for current smokers among men and 19.7% for never, 22.2% for former, and 25.2% for current smokers among women. Among never smoking men, odds ratios (ORs) of occupational injury were 2.11 when regularly exposed to passive smoking at work or at home (p=0.025), 2.27 at work (p=0.015), and 3.08 at home (p=0.106), in comparison to never smoking men who were never exposed to passive smoking either at work or at home (referent group). These associations were attenuated to be non-significant, after controlling for potential confounders. Never smoking men with occasional exposure to passive smoking were not significant ORs (1.11-1.19). In contrast, current and former smoking men had significant increases in adjusted ORs (1.57-2.00). In women exposed to smoking there was a non-significant increase in occupational injury. The present study indicates an expected increase in the risk of, occupational injury for current and former smoking men and suggests that exposure to passive smoking is a possible risk factor for never smoking men.
SN - 0277-9536
AD - National Institute of Occupational Safety and Health, Japan; National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
U2 - PMID: 16867309.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106280857&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106183823
T1 - Off-pump surgery is associated with reduced occurrence of stroke and other morbidity as compared with traditional coronary artery bypass grafting: a meta-analysis of systematically reviewed trials.
AU - Sedrakyan A
AU - Wu AW
AU - Parashar A
AU - Bass EB
AU - Treasure T
AU - Sedrakyan, Artyom
AU - Wu, Albert W
AU - Parashar, Amish
AU - Bass, Eric B
AU - Treasure, Tom
Y1 - 2006/11//2006 Nov
N1 - Accession Number: 106183823. Language: English. Entry Date: 20071102. Revision Date: 20161126. Publication Type: journal article; research; systematic review; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266.
KW - Stroke -- Mortality
KW - Clinical Trials -- Trends
KW - Coronary Artery Bypass -- Mortality
KW - Aged
KW - Stroke -- Etiology
KW - Coronary Artery Bypass -- Adverse Effects
KW - Female
KW - Male
KW - Medical Practice, Evidence-Based
KW - Meta Analysis
KW - Middle Age
KW - Morbidity
KW - Human
SP - 2759
EP - 2769
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 37
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background and Purpose: There is growing enthusiasm for coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB). Although deleterious effects of CPB are known, it remains to be proven that avoiding CPB will result in reduction in morbidity. We sought to determine whether off-pump surgery is associated with reduced occurrence of adverse outcomes as compared with CABG with CPB.Methods: Studies were identified by searching the MEDLINE, EMBASE and the Cochrane Register 1980 to 2006 (February). We also searched the reference lists of randomized clinical trials (RCT) and reviews to look for additional studies.Study Selection: RCTs comparing off-pump surgery to CABG with CPB. No restriction applied on the size of the trial or end point reports.Data Extraction: 2 reviewers independently searched for studies, read abstracts and abstracted all data.Data Synthesis: combined estimates were obtained using fixed or random effect meta-analyses. Relative risks and risk differences were calculated. Heterogeneity was assessed using chi(2) and I(2) values.Results: There were 3996 patients enrolled in 41 RCTs (mean age 62, 22% female). No study reported information on race. Off-pump CABG was associated with a 50% reduction in the relative risk of stroke (95% CI, 7% to 73%), 30% reduction in atrial fibrillation (AF; 95% CI, 16% to 43%) and 48% reduction in wound infection (95% CI, 26% to 63%) with no heterogeneity among RCTs. This translated into avoidance of 10 strokes, 80 cases of AF and 40 infections per 1000 CABG. Fewer distal grafts were performed and there was evidence for >10 reinterventions per 1000 with off-pump CABG. Long-term follow-up is not yet reported in the trials.Conclusions: Off-pump CABG is associated with reduced risk of stroke, AF and infections as compared with CABG with CPB. Evidence should be generalized taking into account RCT enrollment limitations, drawbacks related to training requirements, propensity to perform fewer grafts and likely reinterventions after off-pump surgery.
SN - 0039-2499
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. asedraky@ahrq.gov
U2 - PMID: 17008617.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106183823&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Luebke, Robert W.
AU - Holsapple, Michael P.
AU - Ladics, Gregory S.
AU - Luster, Michael I.
AU - Selgrade, MaryJane
AU - Smialowicz, Ralph J.
AU - Woolhiser, Michael R.
AU - Germoleck, Dori R.
T1 - Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/11//
VL - 94
IS - 1
M3 - Article
SP - 22
EP - 27
PB - Oxford University Press / USA
SN - 10966080
AB - Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and regulatory agencies worldwide. A workshop was held at the Research Triangle Park campus of the Environmental Protection Agency to discuss the current state-of-the-science of “immunotoxicogenomics” and to explore the potential role of genomics techniques for immunotoxicity testing. The genesis of the workshop was the current lack of widely accepted triggering criteria for Tier 1 immunotoxicity testing in the context of routine toxicity testing data, the realization that traditional screening methods would require an inordinate number of animals and are inadequate to handle the number of chemicals that may need to be screened (e.g., high production volume compounds) and the absence of an organized effort to address the state-of-the-science of toxicogenomics in the identification of immunotoxic compounds. The major focus of the meeting was on the theoretical and practical utility of genomics techniques to (1) replace or supplement current immunotoxicity screening procedures, (2) provide insight into potential modes or mechanisms of action, and (3) provide data suitable for immunotoxicity hazard identification or risk assessment. The latter goal is of considerable interest to a variety of stakeholders as a means to reduce animal use and to decrease the cost of conducting and interpreting standard toxicity tests. A number of data gaps were identified that included a lack of dose response and kinetic data for known immunotoxic compounds and a general lack of data correlating genomic alterations to functional changes observed in vivo. Participants concluded that a genomics approach to screen chemicals for immunotoxic potential or to generate data useful to risk assessors holds promise but that routine use of these methods is years in the future. However, recent progress in molecular immunology has made mode and mechanism of action studies much more practical. Furthermore, a variety of published immunotoxicity studies suggest that microarray analysis is already a practical means to explore pathway-level changes that lead to altered immune function. To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Xenobiotics
KW - Immunology
KW - Immunotoxicology
KW - Toxicity testing -- In vivo
KW - Genetic research
KW - EPA
KW - immunotoxicity
KW - immunotoxicogenomics
KW - microarray analysis
KW - risk assessment
KW - United States. Environmental Protection Agency
N1 - Accession Number: 44406610; Luebke, Robert W. 1; Email Address: luebke.robert@epamail.epa.gov; Holsapple, Michael P. 2; Ladics, Gregory S. 3; Luster, Michael I. 4; Selgrade, MaryJane 1; Smialowicz, Ralph J. 1; Woolhiser, Michael R. 5; Germoleck, Dori R. 6; Affiliations: 1: Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711; 2: International Life Sciences Institute, Health and Environmental Sciences Institute, Washington, District of Columbia 20005; 3: DuPont Crop Genetics, Wilmington, Delaware 19880; 4: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; 5: Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674; 6: KNational Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Issue Info: Nov2006, Vol. 94 Issue 1, p22; Thesaurus Term: Risk assessment; Thesaurus Term: Xenobiotics; Thesaurus Term: Immunology; Subject Term: Immunotoxicology; Subject Term: Toxicity testing -- In vivo; Subject Term: Genetic research; Author-Supplied Keyword: EPA; Author-Supplied Keyword: immunotoxicity; Author-Supplied Keyword: immunotoxicogenomics; Author-Supplied Keyword: microarray analysis; Author-Supplied Keyword: risk assessment ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1093/toxsci/kfl074
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wintz, Henri
AU - Yoo, Leslie J.
AU - Loguinov, Alex
AU - Ying-Ying Wu
AU - Steevens, Jeffrey A.
AU - Holland, Ricky D.
AU - Beger, Richard D.
AU - Perkins, Edward J.
AU - Hughes, Owen
AU - Vulpe, Chris D.
T1 - Gene Expression Profiles in Fathead Minnow Exposed to 2,4-DNT: Correlation with Toxicity in Mammals.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/11//
VL - 94
IS - 1
M3 - Article
SP - 71
EP - 82
PB - Oxford University Press / USA
SN - 10966080
AB - Toxicogenomics, the genome-wide analysis of gene expression to study the effect of toxicants, has great potential for use in environmental toxicology. Applied to standard test organisms, it has possible applications in aquatic toxicology as a sensitive monitoring tool to detect the presence of contaminants while providing information on the mechanisms of action of these pollutants. We describe the use of a complementary DNA (cDNA) microarray of the fathead minnow (Pimephales promelas) a standard sentinel organism in aquatic toxicology, to better understand the mechanisms of toxicity of 2,4-dinitrotoluene (2,4-DNT) which is released in the environment through military and industrial use. We have constructed a fathead minnow microarray containing 5000 randomly picked anonymous cDNAs from a whole fish cDNA library. Expression profiles were analyzed in fish exposed to 2,4-DNT for 10 days at three concentrations (11, 22, and 44μM, respectively) below the measured median lethal concentration (58μM). Sequence analysis of cDNAs corresponding to differentially expressed genes affected by exposure revealed that lipid metabolism and oxygen transport genes were prominently affected in a dose-specific manner. We measured liver lipids and demonstrate that lipid metabolism is indeed perturbed following exposure. These observations correlate well with available toxicological data on 2,4-DNT. We present possible modes of action of 2,4-DNT toxicity and suggest that fathead minnow cDNA microarrays can be useful to identify mechanisms of toxicity in fish and as a predictive tool for toxicity in mammals. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dinitrotoluenes
KW - Organonitrogen compounds
KW - Toxicogenomics
KW - Peroxisomes
KW - Methemoglobinemia
KW - Protein microarrays
KW - dinitrotoluene
KW - ecotoxicogenomics
KW - methemoglobinemia
KW - microarrays
KW - peroxisome proliferators
N1 - Accession Number: 44406615; Wintz, Henri 1; Email Address: wintz@berkeley.edu; Yoo, Leslie J. 1,2; Loguinov, Alex 1; Ying-Ying Wu 1; Steevens, Jeffrey A. 2; Holland, Ricky D. 3; Beger, Richard D. 3; Perkins, Edward J. 2; Hughes, Owen 4; Vulpe, Chris D. 1; Affiliations: 1: Department of Nutritional Sciences and Toxicology, Morgan Hall and Berkeley Institute of the Environment, University of California, Berkeley, California 94720; 2: US Army Corps of Engineer Research and Development Center , Environmental Laboratory, Vicksburg, Mississippi 39180; 3: Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; 4: Eon Corporation, Davis, California 95616; Issue Info: Nov2006, Vol. 94 Issue 1, p71; Thesaurus Term: Dinitrotoluenes; Thesaurus Term: Organonitrogen compounds; Thesaurus Term: Toxicogenomics; Subject Term: Peroxisomes; Subject Term: Methemoglobinemia; Subject Term: Protein microarrays; Author-Supplied Keyword: dinitrotoluene; Author-Supplied Keyword: ecotoxicogenomics; Author-Supplied Keyword: methemoglobinemia; Author-Supplied Keyword: microarrays; Author-Supplied Keyword: peroxisome proliferators; Number of Pages: 12p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfl080
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dertinger, Stephen D.
AU - Bishop, Michelle E.
AU - McNamee, James P.
AU - Hayashi, Makoto
AU - Suzuki, Takayoshi
AU - Asano, Norihide
AU - Nakajima, Madoka
AU - Saito, Junichiro
AU - Moore, Martha
AU - Torous, Dorothea K.
AU - MacGregork, James T.
T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes: I. Intra- and Interlaboratory Comparison with Microscopic Scoring.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/11//
VL - 94
IS - 1
M3 - Article
SP - 83
EP - 91
PB - Oxford University Press / USA
SN - 10966080
AB - Accumulating evidence suggests that reticulocytes (RETs) in the peripheral blood of rats may represent a suitable cell population for use in the micronucleus assay, despite the ability of the rat spleen to selectively remove micronucleated erythrocytes from the peripheral circulation. To evaluate the analytical performance of a previously described flow cytometric method (Torous et al., 2003, Toxicol. Sci. 74, 309–314) that may allow this assay to be conducted using peripheral blood in lieu of bone marrow sampling, we compared the sensitivity and performance characteristics of the flow cytometric technique with two established microscopy-based scoring methods. Peripheral blood samples from single Sprague-Dawley rats treated for 6 days with either vehicle or cyclophosphamide were prepared in replicate for scoring by the three methods at different laboratories. These blood-based measurements were compared to those derived from bone marrow specimens from the same animals, stained with acridine orange, and scored by microscopy. Through the analysis of replicate specimens, inter- and intralaboratory variability were evaluated for each method. Scoring reproducibility over time was also evaluated. These data support the premise that rat RETs harvested from peripheral blood are a suitable cell population to assess genotoxicant-induced micronucleus formation. The interlaboratory comparison provides evidence of the general robustness of the micronucleus endpoint using different analytical approaches. Furthermore, data presented herein demonstrate a clear advantage of flow cytometry–based scoring over microscopy—significantly lower inter- and intralaboratory variation and higher statistical sensitivity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytometry
KW - Bone marrow -- Blood-vessels
KW - Reticulocytes
KW - Nucleolus
KW - Hematopoietic system
KW - Blood cells
KW - Cytological techniques
KW - CD71
KW - flow cytometric analysis
KW - micronucleus test
KW - reticulocytes
N1 - Accession Number: 44406611; Dertinger, Stephen D. 1; Bishop, Michelle E. 2; McNamee, James P. 3; Hayashi, Makoto 4; Suzuki, Takayoshi 4; Asano, Norihide 5; Nakajima, Madoka 6; Saito, Junichiro 7; Moore, Martha 2; Torous, Dorothea K. 1; MacGregork, James T. 8; Email Address: jtmacgregor@earthlink.net; Affiliations: 1: Litron Laboratories, Rochester, New York 14623; 2: U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079; 3: Health Canada, Ottawa, Ontario, Canada K1A 0L2; 4: National Institute of Health Sciences, Tokyo 158-8501, Japan; 5: Nitto Denko Corporation, Osaka 567-8680, Japan; 6: An-Pyo Center, Shizuoka 437-1213, Japan; 7: Astellas Pharma Inc., Tokyo 174-8511, Japan; 8: U.S. Food and Drug Administration, National Center for Toxicological Research, Rockville, Maryland 21012; Issue Info: Nov2006, Vol. 94 Issue 1, p83; Thesaurus Term: Cytometry; Subject Term: Bone marrow -- Blood-vessels; Subject Term: Reticulocytes; Subject Term: Nucleolus; Subject Term: Hematopoietic system; Subject Term: Blood cells; Subject Term: Cytological techniques; Author-Supplied Keyword: CD71; Author-Supplied Keyword: flow cytometric analysis; Author-Supplied Keyword: micronucleus test; Author-Supplied Keyword: reticulocytes; Number of Pages: 9p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfl075
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MacGregor, James T.
AU - Bishop, Michelle E.
AU - McNamee, James P.
AU - Hayashi, Makoto
AU - Asano, Norhide
AU - Wakata, Akihiro
AU - Nakajima, Madoka
AU - Saito, Junichiro
AU - Aidoo, Anane
AU - Moore, Martha M.
AU - Dertinger, Stephen D.
T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes: II. An Efficient Method of Monitoring Chromosomal Damage in the Rat.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/11//
VL - 94
IS - 1
M3 - Article
SP - 92
EP - 107
PB - Oxford University Press / USA
SN - 10966080
AB - We have evaluated a flow cytometric method that allows assessment of micronucleated reticulocytes (MN-RETs) in microliter quantities of peripheral blood and compared results using this assay with those of established microscopic methods of scoring bone marrow and peripheral blood from rats treated with well-characterized genotoxic agents. Young reticulocytes (RETs) are labeled with FITC–anti-CD71 (transferrin receptor) and micronuclei with propidium iodide (with RNase treatment). Red blood cells parasitized with Plasmodia serve as a calibration standard for DNA content. Microscopic scoring used acridine orange (AO) staining of methanol-fixed slides or supravital AO staining. The effect of the rat spleen on the parameters evaluated was determined by comparing age- and sex-matched normal and splenectomized rats treated with cyclophosphamide, cis-platin, or vinblastine under treatment conditions that established a steady-state frequency of MN-RETs in the bone marrow and peripheral blood compartments. The data demonstrate the sensitivity and reproducibility of the flow cytometric assay in the Sprague-Dawley rat, and comparative studies using identical blinded samples at multiple laboratories show that inter- and intra-laboratory reproducibility is much higher with the flow method than with the microscopic methods currently employed for regulatory studies. A significant effect of splenic selection against genotoxicant-induced MN-RETs was observed with each of the three scoring methodologies, despite the fact that the flow and supravital AO techniques restrict analysis to the youngest fraction of RETs. The high precision of flow-based measurements also demonstrated a slight but statistically significant level of selection against spontaneously arising MN-RET. Despite these spleen effects, assay sensitivity for blood-based analyses was maintained by the flow method as it was shown to have superior counting statistics, lower variability, and higher sensitivity than manual scoring. The data suggest that flow cytometric assessment of micronucleus induction can be integrated into routine toxicity testing, eliminating the need for a separate bioassay. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cytometry
KW - Reticulocytes
KW - Erythrocytes
KW - Cyclophosphamide (Drug)
KW - Vinblastine
KW - Immune system
KW - cis-platin
KW - cyclophosphamide
KW - erythrocytes
KW - flow cytometric analysis
KW - micronucleated reticulocytes
KW - vinblastine
N1 - Accession Number: 44406612; MacGregor, James T. 1; Email Address: jtmacgregor@earthlink.net; Bishop, Michelle E. 2; McNamee, James P. 3; Hayashi, Makoto 4; Asano, Norhide 5; Wakata, Akihiro 6; Nakajima, Madoka 7; Saito, Junichiro 8; Aidoo, Anane 2; Moore, Martha M. 2; Dertinger, Stephen D. 9; Affiliations: 1: FDA National Center for Toxicological Research, Rockville, Maryland 21012; 2: FDA National Center for Toxicological Research, Jefferson, Arkansas 72079; 3: Health Canada, Ottawa, Ontario, Canada K1A 0L2; 4: National Institute of Health Sciences, Tokyo 158-8501, Japan; 5: Nitto Denko Corporation, Osaka 567-8680, Japan; 6: Astellas Pharma, Inc., Osaka 532-8514, Japan; 7: An-Pyo Center , Shizuoka 437-1213, Japan; 8: Astellas Pharma Inc., Tokyo 174-8511, Japan; 9: Litron Laboratories, Rochester, New York 14623; Issue Info: Nov2006, Vol. 94 Issue 1, p92; Thesaurus Term: Cytometry; Subject Term: Reticulocytes; Subject Term: Erythrocytes; Subject Term: Cyclophosphamide (Drug); Subject Term: Vinblastine; Subject Term: Immune system; Author-Supplied Keyword: cis-platin; Author-Supplied Keyword: cyclophosphamide; Author-Supplied Keyword: erythrocytes; Author-Supplied Keyword: flow cytometric analysis; Author-Supplied Keyword: micronucleated reticulocytes; Author-Supplied Keyword: vinblastine; Number of Pages: 16p; Illustrations: 2 Charts, 9 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfl076
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roney, Nickolette
AU - Osierb, Mark
AU - Paikoff, Sari J.
AU - Smith, Cassandra V.
AU - Williamsa, Malcolm
AU - de Rosa, Christopher T.
T1 - ATSDR evaluation of the health effects of zinc and relevance to public health.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2006/11//
VL - 22
IS - 10
M3 - Article
SP - 423
EP - 493
PB - Sage Publications, Ltd.
SN - 07482337
AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites, which have the greatest public health impact. These profiles comprehensively summarise toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Zinc. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of zinc. It contains descriptions and evaluations of toxicological studies and epidemiological investigations, and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicity testing
KW - Epidemiology -- Research
KW - Toxicology
KW - Public health
KW - Toxicologists
KW - Zinc -- Physiological effect
KW - Physicians (General practice)
KW - United States
KW - United States. Agency for Toxic Substances & Disease Registry
N1 - Accession Number: 25218993; Roney, Nickolette 1; Osierb, Mark 2; Paikoff, Sari J. 2; Smith, Cassandra V. 1; Williamsa, Malcolm 1; de Rosa, Christopher T. 1; Affiliations: 1: Agency for Toxic Substances and Disease Registry (ATSDR), US Department of Health and Human Services, Atlanta, GA, USA; 2: Syracuse Research Corporation, Syracuse, NY, USA; Issue Info: 2006, Vol. 22 Issue 10, p423; Thesaurus Term: Toxicity testing; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: Toxicology; Thesaurus Term: Public health; Thesaurus Term: Toxicologists; Subject Term: Zinc -- Physiological effect; Subject Term: Physicians (General practice); Subject: United States ; Company/Entity: United States. Agency for Toxic Substances & Disease Registry; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 71p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mpanju, Onesmo M.
AU - Towner, Jonathan S.
AU - Dover, Jason E.
AU - Nichol, Stuart T.
AU - Wilson, Carolyn A.
T1 - Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry
JO - Virus Research
JF - Virus Research
Y1 - 2006/11//
VL - 121
IS - 2
M3 - Article
SP - 205
EP - 214
SN - 01681702
AB - Abstract: Using site-directed mutagenesis and retroviral vector pseudotyping of the wild type or mutated glycoprotein of Zaire ebolavirus (ZEBOV), we analyzed 15 conserved residues in the N-terminus of the filovirus glycoprotein 1 (GP1) in order to identify residues critical for cell entry. Results from infectivity assays and Western blot analyses identified two phenylalanine residues at positions 88 and 159 that appear to be critical for ZEBOV entry in vitro. We extended this observation by introduction of alanines at either position 88 or 159 of Ivory Coast Ebolavirus (CIEBOV) and observed the same phenotype. Further, we showed that introduction of each of the two mutations in a recombinant full-length clone of ZEBOV (Mayinga strain) that also carried the coding sequence for GFP could not be rescued, suggesting the mutants rendered the virus non-infectious. The two phenylalanines that are critical for both ZEBOV and CIEBOV entry are found in two linear domains of GP1 that are highly conserved among filoviruses, and thus could provide a target for rational development of broadly cross-protective vaccines or antiviral therapies. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - EBOLA virus disease
KW - GLYCOPROTEINS
KW - ANTIVIRAL agents
KW - Ebolavirus
KW - Filovirus
KW - Glycoprotein
KW - Mutagenesis
KW - Viral entry
N1 - Accession Number: 22580514; Mpanju, Onesmo M. 1 Towner, Jonathan S. 2 Dover, Jason E. 2 Nichol, Stuart T. 2 Wilson, Carolyn A. 1; Email Address: carolyn.wilson@fda.hhs.gov; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-725, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, MS G-14 Atlanta, GA 30329, USA; Source Info: Nov2006, Vol. 121 Issue 2, p205; Subject Term: AMINO acids; Subject Term: EBOLA virus disease; Subject Term: GLYCOPROTEINS; Subject Term: ANTIVIRAL agents; Author-Supplied Keyword: Ebolavirus; Author-Supplied Keyword: Filovirus; Author-Supplied Keyword: Glycoprotein; Author-Supplied Keyword: Mutagenesis; Author-Supplied Keyword: Viral entry; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.virusres.2006.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thorpe, S. J.
AU - Fox, B.
AU - Heath, A. B.
AU - Scott, M.
AU - de Haas, M.
AU - Kochman, S.
AU - Padilla, A.
T1 - International standards for minimum potency of anti-A and anti-B blood grouping reagents: evaluation of candidate preparations in an international collaborative study.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2006/11//
VL - 91
IS - 4
M3 - Article
SP - 336
EP - 344
PB - Wiley-Blackwell
SN - 00429007
AB - Background and Objectives The aim of the study was to evaluate lyophilized monoclonal IgM anti-A and anti-B preparations for use as international standards (IS) to specify recommended minimum potencies of anti-A and anti-B blood grouping reagents in tube tests. Materials and Methods The candidate IS for minimum potency of anti-A and anti-B blood grouping reagents, codes 03/188 and 03/164, respectively, were evaluated against a wide range of commercial anti-A and anti-B blood grouping reagents in an international collaborative study involving 16 laboratories in nine countries. Laboratories titrated 03/188 and 03/164 in parallel with as many commercial anti-A and anti-B blood grouping reagents, respectively, as were available to them, in tube tests according to specified haemagglutination methodology. Three of these laboratories and a further laboratory also titrated 03/188 and 03/164 in parallel with currently available reference preparations for anti-A and anti-B. The ratios of the mean endpoint titres of the anti-A and anti-B reagents to those of 03/188 and 03/164, respectively, within each laboratory were calculated. Results The ratios of the mean titres of the anti-A reagents to the mean titre of 03/188 within a laboratory fell within 0·062 and 4, i.e. the potencies of the anti-A reagents were between a sixteenth to four times as strong as 03/188. The ratios of the mean titres of the anti-B reagents to the mean titre of 03/164 within a laboratory also fell within 0·062 and 4, with one outlier. Conclusions By international consensus, a 1 in 8 dilution of the candidate IS for anti-A, 03/188, and a 1 in 4 dilution of the candidate IS for anti-B, 03/164, were considered appropriate to define the recommended minimum potencies of anti-A and anti-B blood grouping reagents, respectively, in tube tests. On the basis of these results, preparations 03/188 and 03/164 were established by the World Health Organization as International Standards for Minimum Potency of Anti-A and Anti-B Blood Grouping Reagents respectively, and by the US Food and Drug Administration Center for Biologics Evaluation and Research as Minimum Potency Reference Reagents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENS
KW - BLOOD groups
KW - IMMUNOGLOBULINS
KW - AGGLUTINATION of blood
KW - MONOCLONAL antibodies
KW - HEMAGGLUTINATION tests
KW - CHEMICAL tests & reagents
KW - grouping reagents
KW - potency
KW - safety
KW - specifications
KW - standardization
N1 - Accession Number: 23017437; Thorpe, S. J. 1; Email Address: sthorpe@nibsc.ac.uk Fox, B. 1 Heath, A. B. 1 Scott, M. 2 de Haas, M. 3 Kochman, S. 4 Padilla, A. 5; Affiliation: 1: National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK 2: International Blood Group Reference Laboratory, Bristol, UK 3: Sanquin CLB, Amsterdam, The Netherlands 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 5: World Health Organization, Geneva, Switzerland; Source Info: Nov2006, Vol. 91 Issue 4, p336; Subject Term: ANTIGENS; Subject Term: BLOOD groups; Subject Term: IMMUNOGLOBULINS; Subject Term: AGGLUTINATION of blood; Subject Term: MONOCLONAL antibodies; Subject Term: HEMAGGLUTINATION tests; Subject Term: CHEMICAL tests & reagents; Author-Supplied Keyword: grouping reagents; Author-Supplied Keyword: potency; Author-Supplied Keyword: safety; Author-Supplied Keyword: specifications; Author-Supplied Keyword: standardization; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 6 Diagrams; Document Type: Article
L3 - 10.1111/j.1423-0410.2006.00834.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23017437&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106301823
T1 - Health, preventive health care, and health care access among women with disabilities in the 1994-1995 National Health Interview Survey, Supplement on Disability.
AU - Chevarley FM
AU - Thierry JM
AU - Gill CJ
AU - Ryerson AB
AU - Nosek MA
Y1 - 2006/11//
N1 - Accession Number: 106301823. Language: English. Entry Date: 20070615. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9101000.
KW - Disability Evaluation
KW - Disabled
KW - Health Services Accessibility
KW - Preventive Health Care
KW - Women's Health Services
KW - Adult
KW - Aged
KW - Breast Neoplasms -- Prevention and Control
KW - Cervical Smears
KW - Colorectal Neoplasms -- Prevention and Control
KW - Female
KW - Genital Neoplasms, Female -- Prevention and Control
KW - Health Screening
KW - Health Services Research
KW - Mammography
KW - Middle Age
KW - P-Value
KW - Retrospective Design
KW - United States
KW - Women's Health
KW - Human
SP - 297
EP - 312
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 16
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Maryland 20850, USA. Fran.Chevarley@AHRQ.hhs.gov
U2 - PMID: 17188213.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106301823&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Razzano, Lisa A.
AU - Hamilton, Marie M.
AU - Perloff, Judith K.
T1 - Work status, benefits, and financial resources among people with HIV/AIDS.
JO - Work
JF - Work
Y1 - 2006/11//
VL - 27
IS - 3
M3 - Article
SP - 235
EP - 245
PB - IOS Press
SN - 10519815
AB - With the advent of more advanced treatments and therapies, people with HIV/AIDS are experiencing significant improvements in their health, making many of their ongoing employment and career goals more realistic. However, people with HIV/AIDS continue to have major concerns regarding the impact of working on their benefits and entitlements, including apprehensions about potential economic hardships related to loss of financial supports and health insurance coverage. This article focuses on factors related to employment status, sources of health benefits, and entitlements among people with HIV/AIDS. In addition, results of the study demonstrate differences in employment status, benefit types, and the amount of financial support individuals receive based on gender. [ABSTRACT FROM AUTHOR]
AB - Copyright of Work is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health
KW - Therapeutics
KW - AIDS patients
KW - HIV-positive persons
KW - Employment (Economic theory)
KW - Employment
KW - financial resources
KW - gender
KW - HIV/AIDS
N1 - Accession Number: 22420778; Razzano, Lisa A. 1; Email Address: Razzano@psych.uic.edu; Hamilton, Marie M. 1; Perloff, Judith K. 2; Affiliations: 1: Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois, Chicago, Chicago, IL, USA; 2: Chicago House & Social Service Agency, Inc., 1925 North Clybourn, Suite 401, Chicago, IL, USA; Issue Info: 2006, Vol. 27 Issue 3, p235; Thesaurus Term: Health; Subject Term: Therapeutics; Subject Term: AIDS patients; Subject Term: HIV-positive persons; Subject Term: Employment (Economic theory); Author-Supplied Keyword: Employment; Author-Supplied Keyword: financial resources; Author-Supplied Keyword: gender; Author-Supplied Keyword: HIV/AIDS; Number of Pages: 11p; Illustrations: 4 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=22420778&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106216236
T1 - Work status, benefits, and financial resources among people with HIV/AIDS.
AU - Razzano LA
AU - Hamilton MM
AU - Perloff JK
Y1 - 2006/11//
N1 - Accession Number: 106216236. Language: English. Entry Date: 20070119. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Europe; Peer Reviewed; UK & Ireland. Grant Information: Funded under the Field-Initiated Research Grant Program, No. H133G010093, United States Department of Education, National Institute on Disability & Rehabilitation Research. NLM UID: 9204382.
KW - AIDS Patients
KW - Employment Status
KW - Financial Management
KW - Adult
KW - Analysis of Variance
KW - Chi Square Test
KW - Descriptive Statistics
KW - Economic and Social Security
KW - Female
KW - Funding Source
KW - Illinois
KW - Interviews
KW - Male
KW - Medicaid
KW - Nonparametric Statistics
KW - P-Value
KW - Sex Factors
KW - Human
SP - 235
EP - 245
JO - Work
JF - Work
JA - WORK
VL - 27
IS - 3
PB - IOS Press
AB - With the advent of more advanced treatments and therapies, people with HIV/AIDS are experiencing significant improvements in their health, making many of their ongoing employment and career goals more realistic. However, people with HIV/AIDS continue to have major concerns regarding the impact of working on their benefits and entitlements, including apprehensions about potential economic hardships related to loss of financial supports and health insurance coverage. This article focuses on factors related to employment status, sources of health benefits, and entitlements among people with HIV/AIDS. In addition, results of the study demonstrate differences in employment status, benefit types, and the amount of financial support individuals receive based on gender.
SN - 1051-9815
AD - Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, M/C 913, Chicago, IL 60612; Razzano@psych.uic.edu
U2 - PMID: 17006000.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106216236&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-21491-003
AN - 2006-21491-003
AU - Turk, Dennis C.
AU - Dworkin, Robert H.
AU - Burke, Laurie B.
AU - Gershon, Richard
AU - Rothman, Margaret
AU - Scott, Jane
AU - Allen, Robert R.
AU - Atkinson, J. Hampton
AU - Chandler, Julie
AU - Cleeland, Charles
AU - Cowan, Penny
AU - Dimitrova, Rozalina
AU - Dionne, Raymond
AU - Farrar, John T.
AU - Haythornthwaite, Jennifer A.
AU - Hertz, Sharon
AU - Jadad, Alejandro R.
AU - Jensen, Mark P.
AU - Kellstein, David
AU - Kerns, Robert D.
AU - Manning, Donald C.
AU - Martin, Susan
AU - Max, Mitchell B.
AU - McDermott, Michael P.
AU - McGrath, Patrick
AU - Moulin, Dwight E.
AU - Nurmikko, Turo
AU - Quessy, Steve
AU - Raja, Srinivasa
AU - Rappaport, Bob A.
AU - Rauschkolb, Christine
AU - Robinson, James P.
AU - Royal, Mike A.
AU - Simon, Lee
AU - Stauffer, Joseph W.
AU - Stucki, Gerold
AU - Tollett, Jane
AU - von Stein, Thorsten
AU - Wallace, Mark S.
AU - Wernicke, Joachim
AU - White, Richard E.
AU - Williams, Amanda C.
AU - Witter, James
AU - Wyrwich, Kathleen W.
T1 - Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2006/11//
VL - 125
IS - 3
SP - 208
EP - 215
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Turk, Dennis C., University of Washington, Seattle, WA, US, 98195
N1 - Accession Number: 2006-21491-003. PMID: 17069973 Partial author list: First Author & Affiliation: Turk, Dennis C.; University of Washington, Seattle, WA, US. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20070212. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Pain; Classical Test Theory; Clinical Trials; Item Response Theory; Psychometrics. Classification: Clinical Psychological Testing (2224); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2006.
AB - There is a lack of standardized and comprehensive outcome measures for pain trials that have adequate comparative information for relevant samples, that can be used across a variety of research applications, and that allow investigators to combine or compare groups with different demographic or disease characteristics. Measures based on classical test theory (CTT) have a number of limitations, including respondent burden, inability to compare measures putatively assessing the same construct, and assumptions about linearity that may be unwarranted. Item response theory (IRT) methods offer potential advantages, and there is a growing awareness of the potential of IRT to complement and even replace some traditional psychometric approaches. Computer Adaptive Testing (CAT) will likely be used increasingly as the technology improves and familiarity with this approach grows. The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) recommended that six core outcome domains should be considered when designing chronic pain clinical trials: (1) pain; (2) physical functioning; (3) emotional functioning; (4) participant ratings of improvement and satisfaction with treatment; (5) symptoms and adverse events; and (6) participant disposition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chronic pain
KW - clinical trials
KW - patient-reported outcomes
KW - psychometrics
KW - Computer Adaptive Testing
KW - classical test theory
KW - item response theory
KW - 2006
KW - Chronic Pain
KW - Classical Test Theory
KW - Clinical Trials
KW - Item Response Theory
KW - Psychometrics
KW - 2006
U1 - Sponsor: Abbott Laboratories. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Allergan. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Alpharma. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: AstraZeneca. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Celgene. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Eli Lilly and Co.. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: NeurogesX. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Novartis Pharmaceuticals. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Pfizer. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Schwarz Biosciences. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
DO - 10.1016/j.pain.2006.09.028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21491-003&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3761-8704
UR -
UR - Turkdc@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00747-003
AN - 2007-00747-003
AU - Chevarley, Frances M.
AU - Thierry, JoAnn M.
AU - Gill, Carol J.
AU - Ryerson, A. Blythe
AU - Nosek, Margaret A.
T1 - Health, Preventive Health Care, and Health Care Access Among Women with Disabilities in the 1994-1995 National Health Interview Survey, Supplement on Disability.
T3 - Women and Disabilities
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2006/11//Nov-Dec, 2006
VL - 16
IS - 6
SP - 297
EP - 312
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Chevarley, Frances M., Center for Financing Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-00747-003. PMID: 17188213 Partial author list: First Author & Affiliation: Chevarley, Frances M.; Center for Financing Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, US. Release Date: 20070528. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disabilities; Health Care Delivery; Health Care Services; Human Females; Prevention. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Nov-Dec, 2006.
AB - Objectives: This study presents national estimates on the health, preventive health care, and health care access of adult women with disabilities. We compared women with 1 or 2 functional limitations (FLs) and ≥3 FLs with women with no FLs. Topics covered included demographic characteristics, selected reported health measures, selected clinical preventive services, and selected access to care indicators and health care coverage. Methods: Estimates in this report were based on data from the 1994-1995 National Health Interview Survey, Supplement on Disability (NHIS-D). The sample size for women ≥18 years of age used in producing the estimates from the combined 1994 and 1995 NHIS-D was 77,762. Results: An estimated 16% of women ≥18 years of age had difficulty with at least 1 FL. Women with FLs were less likely to rate their health as excellent or very good and more likely to report their health as fair or poor when compared with women with no FLs. Women with FLs were also more likely to report being a current smoker, having hypertension, being overweight, and experiencing mental health problems. Among women ≥65 years of age, those with FLs were also less likely to have received Pap smear tests within the past year and those with ≥3 FLs were less likely to have received mammograms within the past year than women with no FLs. Women with ≥3 FLs were more likely to report being unable to get general medical care, dental care, prescription medicines, or eyeglasses, regardless of age group, compared with women with no FLs. The main reasons reported for being unable to receive general care were financial problems or limitations in insurance. These findings suggest that increased attention to the health care needs of women with disabilities from researchers, clinicians, and public health professionals is warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health
KW - preventive health care
KW - health care access
KW - women
KW - disabilities
KW - 2006
KW - Disabilities
KW - Health Care Delivery
KW - Health Care Services
KW - Human Females
KW - Prevention
KW - 2006
DO - 10.1016/j.whi.2006.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00747-003&site=ehost-live&scope=site
UR - Fran.Chevarley@AHRQ.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-13050-003
AN - 2006-13050-003
AU - Leidy, Nancy Kline
AU - Beusterien, Kathleen
AU - Sullivan, Erin
AU - Richner, Randel
AU - Muni, Neal I.
T1 - Integrating the Patient's Perspective into Device Evaluation Trials.
JF - Value in Health
JO - Value in Health
JA - Value Health
Y1 - 2006/11//
VL - 9
IS - 6
SP - 394
EP - 401
CY - United Kingdom
PB - Blackwell Publishing
SN - 1098-3015
SN - 1524-4733
AD - Leidy, Nancy Kline, Center for Health Outcomes Research, UBC, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD, US, 20814
N1 - Accession Number: 2006-13050-003. PMID: 17076870 Partial author list: First Author & Affiliation: Leidy, Nancy Kline; Center for Health Outcomes Research, United BioSource Corporation, Bethesda, MD, US. Other Publishers: Elsevier Science; Wiley-Blackwell Publishing Ltd. Release Date: 20070402. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Attitudes; Medical Therapeutic Devices; Technology; Therapeutic Processes; Treatment Outcomes. Minor Descriptor: Health; Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Tests & Measures: 36-Item Short Form Health Survey DOI: 10.1037/t07023-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2006.
AB - Innovations in medical device technology have greatly expanded the range of therapeutic options available to physicians and their patients. The understanding of treatment effects from the patient's perspective is an essential component of a comprehensive assessment of any new therapy, including medical devices. The term 'patient-reported outcomes' (PROs) has been growing in use to refer to a cluster of variables such as health-related quality of life, symptoms, physical functioning, psychological wellbeing, treatment satisfaction, and treatment preferences. As in drug trials, the use of PROs in device evaluation has several methodological challenges, ranging from general concerns about interpretation, to more specific issues related to study design and regulatory approval (use of PROs as primary end points, incorporation in labeling, and product promotion). Successful approaches for integrating PROs into device evaluation trials include the careful selection of appropriate, interpretable PRO end points, accounting for possible confounding factors, and the use of alternatives to placebo-controlled trial designs, such as single-arm pre-post, observational, and registry studies, when the use of placebo control groups is not feasible. This article discusses the potential value and difficulties in measuring PROs in device studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient's perspective
KW - device evaluation trials
KW - innovations
KW - medical device technology
KW - therapeutic processes
KW - patient reported outcomes
KW - 2006
KW - Client Attitudes
KW - Medical Therapeutic Devices
KW - Technology
KW - Therapeutic Processes
KW - Treatment Outcomes
KW - Health
KW - Patients
KW - 2006
U1 - Sponsor: Boston Scientific, US. Recipients: No recipient indicated
DO - 10.1111/j.1524-4733.2006.00132.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-13050-003&site=ehost-live&scope=site
UR - nancy.leidy@unitedbiosource.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21928-009
AN - 2006-21928-009
AU - Violanti, John M.
AU - Andrew, Michael E.
AU - Burchfiel, Cecil M.
AU - Dorn, Joan
AU - Hartley, Tara
AU - Miller, Diane B.
T1 - Posttraumatic stress symptoms and subclinical cardiovascular disease in police officers.
JF - International Journal of Stress Management
JO - International Journal of Stress Management
JA - Int J Stress Manag
Y1 - 2006/11//
VL - 13
IS - 4
SP - 541
EP - 554
CY - US
PB - Educational Publishing Foundation
SN - 1072-5245
SN - 1573-3424
AD - Violanti, John M., Department of Social and Preventive Medicine, State University of New York at Buffalo, 270 Farber Hall, Buffalo, NY, US, 14214
N1 - Accession Number: 2006-21928-009. Partial author list: First Author & Affiliation: Violanti, John M.; Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, US. Other Publishers: Kluwer Academic/Human Sciences Press. Release Date: 20061204. Correction Date: 20120514. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cardiovascular Disorders; Occupational Stress; Police Personnel; Posttraumatic Stress Disorder; Risk Factors. Minor Descriptor: Biological Markers; Psychosocial Factors. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Tests & Measures: Impact of Event Scale DOI: 10.1037/t00303-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Nov, 2006. Copyright Statement: American Psychological Association. 2006.
AB - The present study examined associations of posttraumatic stress disorder (PTSD) symptoms with subclinical cardiovascular disease in police officers. A stratified sample of 100 police officers was randomly selected from the Buffalo, New York, Police Department. Cardiovascular disease biomarkers were assessed by ultrasound of the brachial artery (flow-mediated dilation [FMD]). PTSD symptoms were measured with the Impact of Event Scale (IES). FMD was lowest in the severe PTSD symptom category when compared to the mild PTSD symptom category (1.91 vs. 5.15% increase, respectively; p=.21) even after adjustment for lifestyle and demographics. In conclusion, higher PTSD symptomatology in this police sample was associated with a nearly twofold reduction in brachial artery FMD, a biomarker for subclinical cardiovascular disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - police
KW - posttraumatic stress disorder
KW - cardiovascular disease
KW - psychosocial risk factors
KW - biomarkers
KW - job stress
KW - 2006
KW - Cardiovascular Disorders
KW - Occupational Stress
KW - Police Personnel
KW - Posttraumatic Stress Disorder
KW - Risk Factors
KW - Biological Markers
KW - Psychosocial Factors
KW - 2006
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: HELD01B0088. Recipients: No recipient indicated
DO - 10.1037/1072-5245.13.4.541
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21928-009&site=ehost-live&scope=site
UR - violanti@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21845-009
AN - 2006-21845-009
AU - Geller, Jeffrey L.
AU - Fisher, William H.
AU - Grudzinskas, Albert J. Jr.
AU - Clayfield, Jonathan C.
AU - Lawlor, Ted
T1 - Involuntary outpatient treatment as 'desintitutionalized coercion': The net-widening concerns.
JF - International Journal of Law and Psychiatry
JO - International Journal of Law and Psychiatry
JA - Int J Law Psychiatry
Y1 - 2006/11//Nov-Dec, 2006
VL - 29
IS - 6
SP - 551
EP - 562
CY - Netherlands
PB - Elsevier Science
SN - 0160-2527
SN - 1873-6386
AD - Geller, Jeffrey L.
N1 - Accession Number: 2006-21845-009. PMID: 17097143 Partial author list: First Author & Affiliation: Geller, Jeffrey L.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20070430. Correction Date: 20170206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Institutionalization; Mental Disorders; Outpatient Treatment. Minor Descriptor: Coercion; Outpatient Commitment. Classification: Outpatient Services (3371). Population: Human (10); Outpatient (60). References Available: Y. Page Count: 12. Issue Publication Date: Nov-Dec, 2006.
AB - In American jurisprudence, two justifications have traditionally been put forth to support the government's social control of persons with mental illness: police power and parens patriae. As public mental hospitals became less available as loci in which to exercise these functions, governments sought alternative means to achieve the same ends. One prominent but quite controversial means is involuntary outpatient treatment (IOT). While the concerns about IOT have been myriad, one often alluded to but never documented is that of 'net-widening.' That is, once IOT became available, it would be applied to an ever greater number of individuals, progressively expanding the margins of the designated population to whom it is applied, despite the formal standard for its application remaining constant. We tested the net-widening belief in a naturalistic experiment in Massachusetts. We found that net-widening did not occur, despite an environment strongly conducive to that expansion. At this time, whatever the arguments against IOT might be, net-widening should not be one of them. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - involuntary outpatient treatment
KW - deinstitutionalized coercion
KW - mental illness
KW - 2006
KW - Institutionalization
KW - Mental Disorders
KW - Outpatient Treatment
KW - Coercion
KW - Outpatient Commitment
KW - 2006
DO - 10.1016/j.ijlp.2006.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21845-009&site=ehost-live&scope=site
UR - Jeffrey.Geller@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22398-008
AN - 2006-22398-008
AU - Klein, Jonathan D.
AU - Shenkman, Elizabeth
AU - Brach, Cindy
AU - Shone, Laura P.
AU - Schaffer, Virginia A.
AU - Dick, Andrew W.
AU - VanLandeghem, Karen
AU - Szilagyi, Peter G.
T1 - Prior Health Care Experiences of Adolescents who Enroll in SCHIP.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2006/11//
VL - 17
IS - 4
SP - 789
EP - 807
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Klein, Jonathan D.
N1 - Accession Number: 2006-22398-008. PMID: 17242531 Partial author list: First Author & Affiliation: Klein, Jonathan D.; Department of Pediatrics, University of Rochester School of Medicine and Dentistry (URMD), Rochester, NY, US. Release Date: 20070312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Health Insurance; Patient History; Primary Health Care; Socioeconomic Status. Minor Descriptor: Health Care Services; Life Experiences; Racial and Ethnic Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Child and Adolescent Health Measurement Initiative; Young Adult Health Care Survey. Methodology: Empirical Study; Quantitative Study. Page Count: 19. Issue Publication Date: Nov, 2006.
AB - The State Children's Health Insurance Program (SCHIP) was designed to provide health insurance to low-income children and adolescents. Little is known about prior access to care and health care experiences of new SCHIP enrollees. We surveyed Florida and New York new adolescent SCHIP enrollees about their health status, prior health care utilization, access, and unmet needs. Most enrollees were younger (ages 12-16 years), Black or Hispanic, lived in poverty, and were without health insurance the year before SCHIP. Most had a usual source of care (USC) prior to enrollment; Blacks and Hispanics were less likely than Whites to have had a USC. Although 69% of Florida and 80% of New York adolescents reported seeing a physician the year before enrollment, 24% and 40%, respectively, reported unmet health care needs. Only 32% of Florida and 40% of the New York adolescents who were surveyed reported ever having met privately with their clinicians. Many new SCHIP enrollees report unmet needs, disparities in access, and sub-optimal care prior to enrollment. Adolescents' needs should be considered in SCHIP program and quality assurance efforts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health insurance
KW - State Children's Health Insurance Program
KW - health care experiences
KW - adolescents
KW - health status
KW - health care utilization
KW - health care access
KW - poverty
KW - usual source of care
KW - 2006
KW - Health Care Utilization
KW - Health Insurance
KW - Patient History
KW - Primary Health Care
KW - Socioeconomic Status
KW - Health Care Services
KW - Life Experiences
KW - Racial and Ethnic Differences
KW - 2006
U1 - Sponsor: Agency for Healthcare Research and Quality (AHRQ). Grant: NY HS HS10463; FL HS10465. Recipients: No recipient indicated
U1 - Sponsor: Agency for Healthcare Research and Quality, Child Health Insurance Research Initiative (CHIRI™). Recipients: No recipient indicated
U1 - Sponsor: David and Lucile Packard Foundation. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1353/hpu.2006.0127
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22398-008&site=ehost-live&scope=site
UR - jonathan_klein@urmc.rochester.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22398-010
AN - 2006-22398-010
AU - Hill, Steven C.
AU - Wooldridge, Judith
T1 - Informed Participation in TennCare by People with Disabilities.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2006/11//
VL - 17
IS - 4
SP - 851
EP - 875
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Hill, Steven C.
N1 - Accession Number: 2006-22398-010. PMID: 17242535 Partial author list: First Author & Affiliation: Hill, Steven C.; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20070312. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Choice Behavior; Disabilities; Knowledge Level; Managed Care; Medicare. Minor Descriptor: Decision Making; Health Care Services; Medicaid. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Page Count: 25. Issue Publication Date: Nov, 2006.
AB - Informed consumer participation in health care is increasingly important, but people with disabilities face barriers to making health care decisions. Using a unique survey, we examine informed health care choices by nonelderly people with diverse disabilities, including mental retardation, mental illness, visual and hearing impairments, and difficulty communicating, in TennCare, Tennessee's Medicaid managed care program. Most people with disabilities chose their plans and providers, felt they had enough information to choose a plan, and rated information from their providers as good to excellent. A minority did not know they could choose their plans and providers and reported poor or fair communication with providers. Adults with mental retardation were less likely than other adults with disabilities to seek information. Adults with serious difficulty communicating were less satisfied than others with information from providers. Medicare, Medicaid, health plans, and providers should tailor information dissemination to the diverse needs of people with disabilities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - informed participation
KW - health care decisions
KW - managed care
KW - medicaid
KW - mental retardation
KW - disabilities
KW - Tennessee Medicaid
KW - TennCare
KW - managed care program
KW - 2006
KW - Choice Behavior
KW - Disabilities
KW - Knowledge Level
KW - Managed Care
KW - Medicare
KW - Decision Making
KW - Health Care Services
KW - Medicaid
KW - 2006
U1 - Sponsor: US Department of Health and Human Services. Recipients: No recipient indicated
U1 - Sponsor: Assistant Secretary for Planning and Evaluation. Recipients: No recipient indicated
U1 - Sponsor: Health Care Financing Administration. Other Details: contract with Mathematica Policy Research, Inc.. Recipients: No recipient indicated
DO - 10.1353/hpu.2006.0124
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22398-010&site=ehost-live&scope=site
UR - shill@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06289-008
AN - 2007-06289-008
AU - Butcher, Marcene K.
AU - Gilman, Judy
AU - Meszaros, Jane Fitch
AU - Bjorsness, Deb
AU - Madison, Mary
AU - McDowall, Janet M.
AU - Oser, Carrie S.
AU - Johnson, Elizabeth A.
AU - Harwell, Todd S.
AU - Helgerson, Steven D.
AU - Gohdes, Dorothy
T1 - Improving access to quality diabetes education in a rural state: The Montana Quality Diabetes Education Initiative.
JF - The Diabetes Educator
JO - The Diabetes Educator
JA - Diabetes Educ
Y1 - 2006/11//Nov-Dec, 2006
VL - 32
IS - 6
SP - 963
EP - 967
CY - US
PB - Sage Publications
SN - 0145-7217
SN - 1554-6063
AD - Butcher, Marcene K., Montana Department of Public Health and Human Services, Cogswell Building, C-317, PO Box 202951, Helena, MT, US, 59620-2951
N1 - Accession Number: 2007-06289-008. PMID: 17102163 Partial author list: First Author & Affiliation: Butcher, Marcene K.; Montana Department of Public Health and Human Services, Helena, MT, US. Release Date: 20070903. Correction Date: 20090810. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Mentor; Rural Environments; Self-Management. Minor Descriptor: Education. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Nov-Dec, 2006.
AB - Purpose: Diabetes self-management education (DSME) is an integral component of diabetes care; however, skilled educators and recognized programs are not uniformly available in rural communities. Methods: To increase access to quality DSME, the Montana Diabetes Control Program and the Montana chapter of the American Association of Diabetes Educators developed a mentoring program with 3 levels: basic, intermediate, and advanced. All participants were assisted by a volunteer certified diabetes educator (CDE) mentor. In addition, the program provided technical support for recognition through the American Diabetes Association and the Indian Health Service. Results: From 2000 to 2005, 90 individuals participated; 76% were nurses and 21% dietitians. Twenty-seven of the 90 enrollees (30%) completed their structured option, and 13 achieved CDE certification. Most provided services in frontier counties (66%). Statewide, the number of CDEs in Montana increased 46% from 52 in 2000 to 76 in 2005. Twenty-five of the 30 facilities that received technical assistance achieved recognition. Statewide, the number of recognized education programs increased from 2 in 2000 to 22 in 2005. Twelve (55%) of these programs were located in frontier counties. Conclusions: Mentoring and technical support is an effective method to increase personnel skills for DSME and to increase access to quality education programs in rural areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality diabetes
KW - rural state
KW - Montana Quality Diabetes Education
KW - self management education
KW - 2006
KW - Diabetes
KW - Mentor
KW - Rural Environments
KW - Self-Management
KW - Education
KW - 2006
U1 - Sponsor: Centers for Disease Control and Prevention, Division of Diabetes Translation. Grant: Cooperative agreement U32/CCU822743-01. Recipients: No recipient indicated
DO - 10.1177/0145721706296029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06289-008&site=ehost-live&scope=site
UR - marcibutcher@msn.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21997-001
AN - 2006-21997-001
AU - Britten, Patricia
AU - Marcoe, Kristin
AU - Yamini, Sedigheh
AU - Davis, Carole
T1 - Development of Food Intake Patterns for the MyPyramid Food Guidance System.
JF - Journal of Nutrition Education and Behavior
JO - Journal of Nutrition Education and Behavior
JA - J Nutr Educ Behav
Y1 - 2006/11//Nov-Dec, 2006
VL - 38
IS - 6, Suppl
SP - S78
EP - S92
CY - Netherlands
PB - Elsevier Science
SN - 1499-4046
SN - 1878-2620
AD - Britten, Patricia, USDA Center for Nutrition Policy and Promotion, 3101 Park Center Drive, Room 1034, Alexandria, VA, US, 22302
N1 - Accession Number: 2006-21997-001. Other Journal Title: Journal of Nutrition Education. Partial author list: First Author & Affiliation: Britten, Patricia; USDA Center for Nutrition Policy and Promotion, Alexandria, VA, US. Other Publishers: BC Decker. Release Date: 20070326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Eating Behavior; Food; Food Intake; Nutrition. Minor Descriptor: Energy Expenditure; Potassium; Sodium; Vitamins. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Nov-Dec, 2006.
AB - Objective: The purpose of this research was to design food intake patterns based on typical American food selections that would meet Dietary Guidelines and Dietary Reference Intake recommendations. Design: Analytic process to identify appropriate amounts from each food group that together will meet nutritional goals for various age/gender groups. Variables Measured: Projected intake of energy, 9 vitamins, 8 minerals, 8 macronutrients, and dietary fiber in each food intake pattern. Analysis: Iterative comparison of nutrients in each food intake pattern to Dietary Reference Intakes and Dietary Guidelines recommendations set as goals for that pattern. Results: Food intake patterns were established that met almost all nutrient goals within estimated energy needs. Intakes of vitamin E at all energy levels, potassium at lower energy levels, and sodium at higher energy levels did not meet goals. Conclusions and Implications: The food intake patterns provide a foundation of food choices that will meet nutritional recommendations. They form the scientific basis for the MyPyramid Food Guidance System and can also be used as a starting point for developing other educational programs or materials. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - food intake patterns
KW - MyPyramid Food Guidance System
KW - typical American food selections
KW - dietary guidelines
KW - vitamins
KW - minerals
KW - nutrients
KW - energy needs
KW - 2006
KW - Eating Behavior
KW - Food
KW - Food Intake
KW - Nutrition
KW - Energy Expenditure
KW - Potassium
KW - Sodium
KW - Vitamins
KW - 2006
DO - 10.1016/j.jneb.2006.08.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21997-001&site=ehost-live&scope=site
UR - Patricia.Britten@cnpp.usda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-20702-010
AN - 2006-20702-010
AU - Guess, Marsha K.
AU - Connell, Kathleen
AU - Schrader, Steven
AU - Reutman, Susan
AU - Wang, Andrea
AU - LaCombe, Julie
AU - Toennis, Christine
AU - Lowe, Brian
AU - Melman, Arnold
AU - Mikhail, Magdy
T1 - Genital Sensation and Sexual Function in Women Bicyclists and Runners: Are Your Feet Safer than Your Seat?
JF - Journal of Sexual Medicine
JO - Journal of Sexual Medicine
JA - J Sex Med
Y1 - 2006/11//
VL - 3
IS - 6
SP - 1018
EP - 1027
CY - United Kingdom
PB - Blackwell Publishing
SN - 1743-6095
SN - 1743-6109
AD - Guess, Marsha K., Department of Obstetrics & Gynecology, Yale University School of Medicine, 333 Cedar Street, Room 308, New Haven, CT, US, 06520
N1 - Accession Number: 2006-20702-010. PMID: 17100935 Partial author list: First Author & Affiliation: Guess, Marsha K.; Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, US. Other Publishers: Elsevier Science; Wiley-Blackwell Publishing Ltd. Release Date: 20070116. Correction Date: 20160229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Athletes; Female Genitalia; Psychosexual Behavior. Classification: Sexual Behavior & Sexual Orientation (2980). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Dennerstein Personal Experience Questionnaire; Female Sexual Distress Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2006.
AB - Introduction: Bicycling is associated with neurological impairment and impotence in men. Similar deficits have not been confirmed in women. Aim: To evaluate the effects of bicycling on genital sensation and sexual function in women. Methods: Healthy, premenopausal, competitive women bicyclists and runners (controls) were compared. Main Outcome Measures: (1) Genital vibratory thresholds (VTs) were determined using the Medoc Vibratory Sensation Analyzer 3000. (2) Sexual function and sexually related distress were assessed by the Dennerstein Personal Experience Questionnaire (SPEQ) and the Female Sexual Distress Scale (FSDS). Results: Forty-eight bicyclists and 22 controls were enrolled. The median age was 33 years. The bicyclists were older, had higher body mass indices (BMIs), were more diverse in their sexual orientation, and were more likely to have a current partner. Bicyclists rode an average of 28.3 ± 19.7 miles/day (range 4-100), 3.8 ± 1.5 days/week, for an average of 2.1 ± 1.8 hours/ride. The mean number of years riding was 7.9 ± 7.1 years (range 0.5-30). Controls ran an average of 4.65 ± 2.1 miles/day (range 1.5-8) and 5.0 ± 1.2 days/week. On bivariate analysis, bicyclists had significantly higher VTs than runners, indicating worse neurological function at all sites (P < 0.05). Multivariate analysis found significant correlations between higher VTs and bicycling at the left and right perineum, posterior vagina, left and right labia. Increasing VTs at the clitoris, anterior vagina, and urethra were associated with age. In bicyclists, there were no correlations between VTs and miles biked per week, duration of riding, or BMI. Composite SPEQ scores indicated normal sexual function in all sexually active subjects. Neither group suffered from sexually related distress. Conclusion: There is an association between bicycling and decreased genital sensation in competitive women bicyclists. Negative effects on sexual function and quality of life were not apparent in our young, healthy premenopausal cohort. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genital sensation
KW - sexual function
KW - women bicyclists and runners
KW - 2006
KW - Athletes
KW - Female Genitalia
KW - Psychosexual Behavior
KW - 2006
U1 - Sponsor: National Institutes of Health. Grant: 3P01DK60037-03S; 5K12HD047018. Recipients: No recipient indicated
U1 - Sponsor: Bronx Center to Reduce & Eliminate Ethnic & Racial Health Disparities (Bronx CREED).. Recipients: No recipient indicated
DO - 10.1111/j.1743-6109.2006.00317.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20702-010&site=ehost-live&scope=site
UR - marsha.guess@yale.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21509-008
AN - 2006-21509-008
AU - Rowan, Anderson B.
AU - Campise, Rick L.
T1 - A Multisite Study of Air Force Outpatient Behavioral Health Treatment-Seeking Patterns and Career Impact.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2006/11//
VL - 171
IS - 11
SP - 1123
EP - 1127
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Rowan, Anderson B., 30th Medical Operations Squadron, Vandenberg Air Force Base, CA, US, 93437
N1 - Accession Number: 2006-21509-008. PMID: 17153554 Partial author list: First Author & Affiliation: Rowan, Anderson B.; 30th Medical Operations Squadron, Vandenberg Air Force Base, CA, US. Release Date: 20070212. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Air Force Personnel; Health Care Seeking Behavior; Mental Health Services; Outpatient Treatment. Minor Descriptor: Age Differences; Diagnosis; Human Sex Differences; Marital Status; Military Duty Status; Professional Referral; Self-Referral. Classification: Outpatient Services (3371); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Nov, 2006.
AB - This study examined 1,068 cases of active duty Air Force service members seen in eight Air Force outpatient mental health clinics during a 1-year period. Age, gender, rank, marital status, special duty status, diagnostic category, treatment completion, and recommendations to the member's unit were examined across referral sources (i.e., self-referred, supervisor-referred, or commander-directed). Results showed significant differences across all variables, with self-referred members being more likely to be older, single, higher ranking, and without special duty status, as well as to have a less significant axis I diagnosis. Self-referred members were less likely to have confidentiality broken and to have career-affecting recommendations made. The implications of these findings, in terms of targeting interventions to increase self-initiated help-seeking behavior, and recommendations for future research are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - Air Force
KW - outpatient behavioral health treatment seeking
KW - career impact
KW - age
KW - gender
KW - rank
KW - marital & special duty status
KW - diagnostic category
KW - treatment completion
KW - recommendations
KW - referral source
KW - 2006
KW - Air Force Personnel
KW - Health Care Seeking Behavior
KW - Mental Health Services
KW - Outpatient Treatment
KW - Age Differences
KW - Diagnosis
KW - Human Sex Differences
KW - Marital Status
KW - Military Duty Status
KW - Professional Referral
KW - Self-Referral
KW - 2006
DO - 10.7205/MILMED.171.11.1123
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21509-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07323-002
AN - 2007-07323-002
AU - Mark, Tami L.
AU - Buck, Jeffrey A.
T1 - Characteristics of U.S. youths with serious emotional disturbance: Data from the National Health Interview Survey.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/11//
VL - 57
IS - 11
SP - 1573
EP - 1578
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Mark, Tami L., 4301 Connecticut Avenue, N.W., Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2007-07323-002. PMID: 17085604 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Medstat, Washington, DC, US. Release Date: 20070910. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychiatry; Child Psychiatry; Emotional Disturbances; Health Insurance; Mental Health Services. Minor Descriptor: Medicaid. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2006.
AB - Objective: Although it is estimated that serious emotional disturbance affects 9 to 13 percent of children and adolescents in the United States, there are few national data on the characteristics of this group. Methods: This study used data for 13,579 youths from the 2001 National Health Interview Survey (NHIS) to describe the sociodemographic features and insurance coverage of youths with serious emotional disturbance living in the United States. Youths with serious emotional disturbance were identified through their scores on the Strengths and Difficulties Questionnaire, which was added to the NHIS in 2001. Results: A large majority of youths with serious emotional disturbance were white and had income at 200 percent of the poverty level or higher. About 40 percent of youths with serious emotional disturbance had private insurance coverage, whereas Medicaid and the State Children's Health Insurance Program provided coverage for about a third of youths with serious emotional disturbance. Conclusions: Although Medicaid is an important payer of mental health services for youths with serious emotional disturbance, private insurance is still the primary source of health coverage for youths with serious emotional disturbance and for the overall population of youths. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - U.S. youths with serious emotional disturbance
KW - National Health Interview Survey
KW - children
KW - adolescents
KW - health insurance
KW - 2006
KW - Adolescent Psychiatry
KW - Child Psychiatry
KW - Emotional Disturbances
KW - Health Insurance
KW - Mental Health Services
KW - Medicaid
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1176/appi.ps.57.11.1573
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07323-002&site=ehost-live&scope=site
UR - tami.mark@thomson.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07323-005
AN - 2007-07323-005
AU - Davis, Maryann
AU - Geller, Jeffrey L.
AU - Hunt, Bethany
T1 - Within-state availability of transition-to-adulthood services for youths with serious mental health conditions.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/11//
VL - 57
IS - 11
SP - 1594
EP - 1599
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Davis, Maryann, Department of Psychiatry, Center for Mental Health Services Research, Universty of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2007-07323-005. PMID: 17085607 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Davis, Maryann; Department of Psychiatry, Center for Mental Health Services Research, Universty of Massachusetts Medical School, Worcester, MA, US. Release Date: 20070910. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Davis, Maryann. Major Descriptor: Mental Health; Mental Health Services. Minor Descriptor: Adolescent Psychiatry. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2006.
AB - Objective: This study describes the existence and nature of services within state child and adult mental health systems that support the transition from adolescence to adulthood. Methods: State child and adult mental health administrators from all but one state were interviewed by telephone with a semistructured questionnaire regarding transition services in their state mental health system, such as supported housing, vocational support, preparation for independent living, and dual diagnosis treatment. Eight states were deemed sufficiently decentralized to render state-level administrator reports invalid. Specific service data from the remaining 41 states and the District of Columbia were analyzed with descriptive statistics. Results: One-quarter of child state mental health systems and one-half of adult state mental health systems offered no transition services, and few provided any kind of transition service at more than one site. Most types of transition services were available at all in less than 20 percent of the states. Conclusions: Across the United States transition support services are lacking. The adult system in particular will require major transformation to provide the service capacity that is needed to meet the current standards of transition service accessibility for young Americans with serious mental health conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - within state availability of transition services
KW - adulthood services
KW - child mental health systems
KW - adult mental health systems
KW - 2006
KW - Mental Health
KW - Mental Health Services
KW - Adolescent Psychiatry
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: 282-98-0029. Recipients: Davis, Maryann
DO - 10.1176/appi.ps.57.11.1594
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07323-005&site=ehost-live&scope=site
UR - maryann.davis@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07323-022
AN - 2007-07323-022
AU - Davis, Maryann
T1 - Review of On your own without a net: The transition to adulthood for vulnerable populations.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2006/11//
VL - 57
IS - 11
SP - 1658
EP - 1659
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2007-07323-022. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20070910. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Adolescent Development; Adult Development; Social Services. Minor Descriptor: Criminal Justice; Disabilities; Foster Care; Homeless; Juvenile Justice; Mental Health; Special Education. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Reviewed Item: Osgood, E. Wayne (Ed); Foster, E. Michael (Ed); Flanagan, Constance (Ed); Ruth, Gretchen R. (Ed). On Your Own Without a Net: The Transition to Adulthood for Vulnerable Populations=Chicago, University of Chicago Press, 432 pages, $40; 2005. Page Count: 2. Issue Publication Date: Nov, 2006.
AB - Reviews the book, On Your Own Without a Net: The Transition to Adulthood for Vulnerable Populations by E. Wayne Osgood, E. Michael Foster, Constance Flanagan, and Gretchen R. Ruth (2005). This volume describes research on adolescents in public systems, such as child welfare, juvenile justice, and mental health--vulnerable populations--as they mature into adulthood. The book couples the research with considerations of policies and programs that impact the population during the transition period. The purpose of the volume is to 'spur policy makers, opinion leaders, and scholars to devote great attention to the issues facing vulnerable populations during the transition to adulthood.' The book covers seven public system populations: foster care, juvenile justice, criminal justice, homeless, special education, mental health, and special health care needs and disabilities. Most populations have a chapter on research on the population and another chapter on related policies and programs. The aim of the research chapters is to describe in what areas of adult life young people are more or less successful, who fares better and who fares worse, and what accounts for those patterns. Each policy chapter aims to review programs, policies, and services that affect the population and the effectiveness, adequacy, and gaps in regard to service delivery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent development
KW - public systems
KW - mental health
KW - vulnerable populations
KW - transition to adulthood
KW - service delivery
KW - 2006
KW - Adolescent Development
KW - Adult Development
KW - Social Services
KW - Criminal Justice
KW - Disabilities
KW - Foster Care
KW - Homeless
KW - Juvenile Justice
KW - Mental Health
KW - Special Education
KW - 2006
U2 - Osgood, E. Wayne (Ed); Foster, E. Michael (Ed); Flanagan, Constance (Ed); Ruth, Gretchen R. (Ed). (2005); On Your Own Without a Net: The Transition to Adulthood for Vulnerable Populations; Chicago, University of Chicago Press, 432 pages, $40
DO - 10.1176/appi.ps.57.11.1658
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07323-022&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-12453-016
AN - 2006-12453-016
AU - Nakata, Akinori
AU - Ikeda, Tomoko
AU - Takahashi, Masaya
AU - Haratani, Takashi
AU - Hojou, Minoru
AU - Fujioka, Yosei
AU - Araki, Shunichi
T1 - Non-fatal occupational injury among active and passive smokers in small- and medium-scale manufacturing enterprises in Japan.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2006/11//
VL - 63
IS - 9
SP - 2452
EP - 2463
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Nakata, Akinori
N1 - Accession Number: 2006-12453-016. PMID: 16867309 Partial author list: First Author & Affiliation: Nakata, Akinori; National Institute of Occupational Safety and Health, Japan. Release Date: 20070430. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Industrial Accidents; Risk Factors; Tobacco Smoking. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Nov, 2006.
AB - Active smoking is a risk factor for occupational injury, whereas its association with passive smoking is unknown. To evaluate the contribution of active and passive smoking to non-fatal occupational injury in manufacturing sectors, 2302 randomly selected workers aged 16-83 years working in 244 small- and medium-scale enterprises in Yashio city, Japan, were surveyed by means of a self-administered questionnaire. Smoking history, exposure to passive smoking, and occupational injury were evaluated by self-report. Exposure levels to passive smoking were assessed separately at work and at home as never, occasional, or regular exposure. Overall, 61.4% of men and 22.3% of women were current smokers. Among never smokers, 62.2% of men and 68.6% of women reported exposure to passive smoking either at work or home. Prevalence of occupational injuries was 36.2% for never, 43.3% for former, and 41.2% for current smokers among men and 19.7% for never, 22.2% for former, and 25.2% for current smokers among women. Among never smoking men, odds ratios (ORs) of occupational injury were 2.11 when regularly exposed to passive smoking at work or at home (p=0.025), 2.27 at work (p=0.015), and 3.08 at home (p=0.106), in comparison to never smoking men who were never exposed to passive smoking either at work or at home (referent group). These associations were attenuated to be non-significant, after controlling for potential confounders. Never smoking men with occasional exposure to passive smoking were not significant ORs (1.11-1.19). In contrast, current and former smoking men had significant increases in adjusted ORs (1.57-2.00). In women exposed to smoking there was a non-significant increase in occupational injury. The present study indicates an expected increase in the risk of, occupational injury for current and former smoking men and suggests that exposure to passive smoking is a possible risk factor for never smoking men. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - non-fatal occupational injury
KW - active smokers
KW - passive smokers
KW - small manufacturing enterprises
KW - medium manufacturing enterprises
KW - risk factors
KW - 2006
KW - Industrial Accidents
KW - Risk Factors
KW - Tobacco Smoking
KW - 2006
U1 - Sponsor: Centers for Disease Control and Prevention, Research Participation Program. Recipients: No recipient indicated
U1 - Sponsor: National Institute for Occupational Safety and Health. Other Details: Administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and CDC. Recipients: No recipient indicated
U1 - Sponsor: Ministry of Education, Culture, Sports, Science and Technology, Japan. Recipients: No recipient indicated
DO - 10.1016/j.socscimed.2006.06.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12453-016&site=ehost-live&scope=site
UR - araki@h.jniosh.go.jp
UR - yosei@guri-gura.com
UR - hojoh@big.or.jp
UR - haratani@h.jniosh.go.jp
UR - takaham@h.jniosh.go.jp
UR - ikedat@ipu.ac.jp
UR - nakataa-tky@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21997-004
AN - 2006-21997-004
AU - Yamini, Sedigheh
AU - Juan, WenYen
AU - Marcoe, Kristin
AU - Britten, Patricia
T1 - Impact of Using Updated Food Consumption and Composition Data on Selected MyPyramid Food Group Nutrient Profiles.
JF - Journal of Nutrition Education and Behavior
JO - Journal of Nutrition Education and Behavior
JA - J Nutr Educ Behav
Y1 - 2006/11//Nov-Dec, 2006
VL - 38
IS - 6, Suppl
SP - S136
EP - S142
CY - Netherlands
PB - Elsevier Science
SN - 1499-4046
SN - 1878-2620
AD - Yamini, Sedigheh, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS830, College Park, MD, US, 20740
N1 - Accession Number: 2006-21997-004. Other Journal Title: Journal of Nutrition Education. Partial author list: First Author & Affiliation: Yamini, Sedigheh; FDA Center for Food Safety and Applied Nutrition, US. Other Publishers: BC Decker. Release Date: 20070326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diets; Food; Food Intake; Nutrition. Minor Descriptor: Vitamins. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Web Sites Internet. References Available: Y. Page Count: 7. Issue Publication Date: Nov-Dec, 2006.
AB - Objective: To examine the changes observed in 5 nutrients of selected USDA food subgroups by partitioning the overall changes into those caused by consumption changes over time, and those caused by nutrient database revisions. Design: Population-weighted estimates of food group intakes (composites) were developed using 24-hour recall data from CSFII 1994-96 and NHANES 1999-2000. Nutrient profiles of these composites were developed using Standard Reference (SR) data (SR11 and SR16-1). Subjects: A total of 14,262 and 8070 individuals over the age of 2 years from CSFII and NHANES, respectively, composed the study sample. Outcome Measures: Absolute and percent change in food group nutrient content caused by food consumption changes and nutrient database updates. Analysis: Changes due to consumption differences were determined by comparing nutrient profiles created with CSFII and NHANES using SR11. Changes due to nutrient database differences were determined by comparing nutrient profiles created from NHANES data using SR11 and SR16-1 nutrient values. Results: Consumption differences resulted in some variations in the food group nutrient content, but a majority of the changes were associated with use of the updated nutrient database. For example, vitamin A level in the orange vegetable subgroup was increased by 2.4% owing to consumption (from CSFII to NHANES), whereas the level was decreased by 38% due to nutrient updates (from SR11 to SR16-1). Conclusion and Implications: Consideration of the changes in nutrient databases, as well as in food consumption, is essential in monitoring both the trends in the food choices Americans make and the adequacy of their diets. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - food consumption changes
KW - food group intakes
KW - nutrient profiles
KW - MyPyramid Food Group Nutrient Profiles
KW - 2006
KW - Diets
KW - Food
KW - Food Intake
KW - Nutrition
KW - Vitamins
KW - 2006
DO - 10.1016/j.jneb.2006.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21997-004&site=ehost-live&scope=site
UR - Essie.Yamini@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21384-020
AN - 2006-21384-020
AU - McHorney, Colleen A.
AU - Fleishman, John A.
T1 - Assessing and Understanding Measurement Equivalence in Health Outcome Measures: Issues for Further Quantitative and Qualitative Inquiry.
T3 - Measurement in a multi-ethnic society
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2006/11//
VL - 44
IS - 11, Suppl 3
SP - S205
EP - S210
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - McHorney, Colleen A., Merck & Co., Inc., 770 Sumneytown Pike, WP39-166, West Point, PA, US, 19486
N1 - Accession Number: 2006-21384-020. Partial author list: First Author & Affiliation: McHorney, Colleen A.; Merck & Co., Inc., West Point, PA, US. Release Date: 20070604. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health; Item Analysis (Statistical); Measurement; Qualitative Research; Quantitative Methods. Minor Descriptor: Mini Mental State Examination. Classification: Research Methods & Experimental Design (2260); Personality Psychology (3100). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2006.
AB - This supplemental issue of Medical Care is devoted to issues of measurement equivalence in diverse populations, particularly populations characterized by health disparities. Five of the articles in this supplement assess differential item functioning (DIF) in the Mini-Mental State Examination. In fact, DIF has been identified in many patient outcome tools, including measures of physical functioning and functional status, cognitive status, quality of life, patient satisfaction, and many mental health measures. Across these studies, DIF has been identified by age, gender, race, ethnicity, socioeconomic status, language, nationality, and healthcare setting. In summary, articles in this supplement collectively provide an excellent overview of the importance of considering DIF when making group comparisons as well as different techniques for identifying DIF. Other important work in this supplement underscores the value of using both classical and modern quantitative methods when addressing measurement equivalence as well as confirmatory factor analysis. Despite the psychometric progress made to date in health outcome measurement, there is much more work to be done to understand the factors that give rise to DIF, to develop instruments that are as free of item bias as possible, and to investigate the consequences of different approaches to dealing with identified DIF. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - measurement equivalence
KW - health outcome
KW - quantitative methods
KW - qualitative methods
KW - differential item functioning
KW - Mini-Mental State Examination
KW - 2006
KW - Health
KW - Item Analysis (Statistical)
KW - Measurement
KW - Qualitative Research
KW - Quantitative Methods
KW - Mini Mental State Examination
KW - 2006
DO - 10.1097/01.mlr.0000245451.67862.57
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21384-020&site=ehost-live&scope=site
UR - colleen_mchorney@merck.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Marcoe, Kristin
AU - Juan, WenYen
AU - Yamini, Sedigheh
AU - Carlson, Andrea
AU - Britten, Patricia
T1 - Development of Food Group Composites and Nutrient Profiles for the MyPyramid Food Guidance System.
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
Y1 - 2006/11/02/Nov/Dec2006 Supplement
VL - 38
M3 - Article
SP - S93
EP - S107
SN - 14994046
AB - Objective: To identify food selections in each MyPyramid food group or subgroup reflective of typical consumption patterns by Americans, and the nutrient intake that can be expected from consuming a specified amount of these foods from each group, in a low-fat and no-added-sugars form. Design: An analytical process to identify food consumption choices within each food group and subgroup using national food consumption surveys, and to identify the expected nutrient content of each group using food composition databases. Variables Measured: Relative consumption of foods within each food group; nutrient content for each food group and subgroup (energy plus 27 nutrients). Analysis: Disaggregated foods from consumption surveys into component ingredients. Combined similar ingredients into "item clusters" and determined relative consumption of each. Calculated a consumption-weighted nutrient profile for each food group. Results: Consumption-weighted food intake selections and nutrient profiles were developed for all MyPyramid food groups and subgroups. Conclusions and Implications: This analytical process derived food group and subgroup composites which estimate typical food choices within each MyPyramid food group. These were used to assess the adequacy of the MyPyramid food intake patterns as they were being iteratively developed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition Education & Behavior is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD consumption -- Research
KW - FOOD -- Composition
KW - FOOD -- Analysis
KW - FOOD preferences
KW - NUTRITION surveys
KW - HEALTH behavior -- Research
KW - NUTRITION research
KW - UNITED States
KW - dietary guidance
KW - food guides
KW - food intake patterns
KW - MyPyramid
N1 - Accession Number: 23493690; Marcoe, Kristin 1; Email Address: Kristin.Marcoe@cnpp.usda.gov Juan, WenYen 1 Yamini, Sedigheh 2 Carlson, Andrea 1 Britten, Patricia 1; Affiliation: 1: USDA Center for Nutrition Policy and Promotion, Alexandria, VA 2: FDA Center for Food Safety and Applied Nutrition, Alexandria, VA; Source Info: Nov/Dec2006 Supplement, Vol. 38, pS93; Subject Term: FOOD consumption -- Research; Subject Term: FOOD -- Composition; Subject Term: FOOD -- Analysis; Subject Term: FOOD preferences; Subject Term: NUTRITION surveys; Subject Term: HEALTH behavior -- Research; Subject Term: NUTRITION research; Subject Term: UNITED States; Author-Supplied Keyword: dietary guidance; Author-Supplied Keyword: food guides; Author-Supplied Keyword: food intake patterns; Author-Supplied Keyword: MyPyramid; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Illustrations: 3 Diagrams, 6 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23493690&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106247897
T1 - Impact of using updated food consumption and composition data on selected MyPyramid Food Group nutrient profiles.
AU - Yamini S
AU - Juan W
AU - Marcoe K
AU - Britten P
Y1 - 2006/11/02/Nov/Dec2006 Supplement
N1 - Accession Number: 106247897. Language: English. Entry Date: 20070309. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Supplement Title: Nov/Dec2006 Supplement. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. NLM UID: 101132622.
KW - Databases, Health
KW - Diet -- Trends
KW - Food Guide Pyramid
KW - Nutrients
KW - Adolescence
KW - Adult
KW - Child
KW - Child, Preschool
KW - Comparative Studies
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Public Health
KW - Questionnaires
KW - Survey Research
KW - United States
KW - Human
SP - S136
EP - 42
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
JA - J NUTR EDUC BEHAV
VL - 38
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To examine the changes observed in 5 nutrients of selected USDA food subgroups by partitioning the overall changes into those caused by consumption changes over time, and those caused by nutrient database revisions. DESIGN: Population-weighted estimates of food group intakes (composites) were developed using 24-hour recall data from CSFII 1994-96 and NHANES 1999-2000. Nutrient profiles of these composites were developed using Standard Reference (SR) data (SR11 and SR16-1). SUBJECTS: A total of 14,262 and 8070 individuals over the age of 2 years from CSFII and NHANES, respectively, composed the study sample. OUTCOME MEASURES: Absolute and percent change in food group nutrient content caused by food consumption changes and nutrient database updates. ANALYSIS: Changes due to consumption differences were determined by comparing nutrient profiles created with CSFII and NHANES using SR11. Changes due to nutrient database differences were determined by comparing nutrient profiles created from NHANES data using SR11 and SR16-1 nutrient values. RESULTS: Consumption differences resulted in some variations in the food group nutrient content, but a majority of the changes were associated with use of the updated nutrient database. For example, vitamin A level in the orange vegetable subgroup was increased by 2.4% owing to consumption (from CSFII to NHANES), whereas the level was decreased by 38% due to nutrient updates (from SR11 to SR16-1). CONCLUSION AND IMPLICATIONS: Consideration of the changes in nutrient databases, as well as in food consumption, is essential in monitoring both the trends in the food choices Americans make and the adequacy of their diets.
SN - 1499-4046
AD - FDA Center for Food Safety and Applied Nutrition, Food andDrug Administration, 5100 Paint Branch Parkway, HFS830, College Park, MD 20740
U2 - PMID: 17116591.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106247897&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Okada, Sarah K.
AU - Siegel, Jeffrey N.
T1 - Risk of Serious Infections and Malignancies With Anti-TNF Antibody Therapy in Rheumatoid Arthritis.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/11/08/
VL - 296
IS - 18
M3 - Letter
SP - 2201
EP - 2202
SN - 00987484
AB - A letter to the editor is presented in response to the article "Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials," by T. Bongartz et al.
KW - LETTERS to the editor
KW - TUMOR necrosis factor
KW - THERAPEUTIC use
N1 - Accession Number: 22994559; Okada, Sarah K. 1 Siegel, Jeffrey N. 1; Email Address: Jeffrey.Siegel@fda.hhs.gov; Affiliation: 1: Division of Anesthesia, Analgesia, and Rheumatology Products Office of Drug Evaluation II Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring, Md; Source Info: 11/8/2006, Vol. 296 Issue 18, p2201; Subject Term: LETTERS to the editor; Subject Term: TUMOR necrosis factor; Subject Term: THERAPEUTIC use; Number of Pages: 2p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22994559&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Azad, Neelam
AU - Vallyathan, Val
AU - Liying Wang
AU - Tantishaiyakui, Vimon
AU - Stehlikm, Christian
AU - Leonardo, Stephen S.
AU - Rojanasakui, Yon
T1 - S-Nitrosylation of Bcl-2 Inhibits Its Ubiquitin-Proteasomal Degradation.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/11/10/
VL - 281
IS - 45
M3 - Article
SP - 34124
EP - 34134
SN - 00219258
AB - Bcl-2 is a key apoptosis regulatory protein of the mitochondrial death pathway whose function is dependent on its expression levels. Although Bcl-2 expression is controlled by various mechanisms, post-translational modifications, such as ubiquitination and proteasomal degradation, have emerged as important regulators of Bcl-2 function. However, the underlying mechanisms of this regulation are unclear. We report here that Bcl-2 undergoes S-nitrosylation by endogenous nitric oxide (NO) in response to multiple apoptotic mediators and that this modification inhibits ubiquitin-proteasomal degradation of Bcl-2. Inhibition of NO production by the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and by NO synthase inhibitor aminoguanidine effectively inhibited S-nitrosylation of Bcl-2, increased its ubiquitination, and promoted apoptotic cell death induced by chromium (VI). In contrast, the NO donors dipropylenetriamine NONOate and sodium nitroprusside showed opposite effects. The effect of NO on Bcl-2 stability was shown to be independent of its dephosphorylation. Mutational analysis of Bcl-2 further showed that the two cysteine residues of Bcl-2 (Cys158 and Cys229) are important in the S-nitrosylation process and that mutations of these cysteines completely inhibited Bcl-2 S-nitrosylation. Treatment of the cells with other stress inducers, including Fas ligand and buthionine sulfoxide, also induced Bcl-2 S-nitrosylation, suggesting that this is a general phenomenon that regulates Bcl-2 stability and function under various stress conditions. These findings indicate a novel function of NO and its regulation of Bcl-2, which provides a key mechanism for the control of apoptotic cell death and cancer development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UBIQUITIN
KW - APOPTOSIS
KW - MITOCHONDRIAL pathology
KW - NITRIC oxide
KW - CELL death
KW - BIOCHEMISTRY
N1 - Accession Number: 23827050; Azad, Neelam 1 Vallyathan, Val 2 Liying Wang 2 Tantishaiyakui, Vimon 3 Stehlikm, Christian 4 Leonardo, Stephen S. 2 Rojanasakui, Yon 1; Email Address: yrojanasakul@hsc.wvu.edu; Affiliation: 1: Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506 2: Pathology and Physiology Research Branch, National Institute for Occupational, Safety and Health, Morgantown, West Virginia 26505 3: Department of Pharmaceutical Chemistry, Songkla University, Songkla 90110, Thailand 4: Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506; Source Info: 11/10/2006, Vol. 281 Issue 45, p34124; Subject Term: UBIQUITIN; Subject Term: APOPTOSIS; Subject Term: MITOCHONDRIAL pathology; Subject Term: NITRIC oxide; Subject Term: CELL death; Subject Term: BIOCHEMISTRY; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 28 Graphs; Document Type: Article
L3 - 10.1074/jbc.M602551200
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Vionnet, Justine
AU - Kempner, Ellis S.
AU - Vann, Willie F.
T1 - Functional Molecular Mass of Escherichia coli K92 Polysialyltransferase As Determined by Radiation Target Analysis.
JO - Biochemistry
JF - Biochemistry
Y1 - 2006/11/14/
VL - 45
IS - 45
M3 - Article
SP - 13511
EP - 13516
SN - 00062960
AB - The polysialyltransferase of Escherichia coli K92 catalyzes the transfer of sialic acid from CMP-sialic acid to a growing chain of polysialic acid at the nonreducing end. The enzyme encoded by the neuS gene is membrane-associated and has been suggested to be organized within a complex of several proteins encoded by the K92 gene cluster. Attempts to prepare a soluble active NeuS enzyme have been unsuccessful. Recent results suggest that de novo synthesis of polysialic acid requires coexpression of four genes from the cluster: neuS, neuE, kpsC, and kpsS. However, elongation of preexisting polysialic acid chains only requires expression of neuS. The molecular organization of the catalytic unit of bacterial polysialyltransferases has not been described. We used radiation inactivation to measure the size of the minimum functional unit catalyzing the polysialyltransferase chain extension and de novo reactions. Membranes harboring NeuS in the presence and absence of other products of the K92 gene cluster were exposed to high-energy electrons. The rate of loss of polysialyltransferase activity reveals the mass of the molecules essential for catalytic activity. We observed that the transfer of neuNAc from CMP-neuNAc to a polysialic acid acceptor is catalyzed by a complex with a target size larger than that of monomeric NeuS. The target size of the unit catalyzing the extension of existing polysialic acid chains does not differ significantly from the size of the unit catalyzing transfer of sialic acid to the endogenous acceptor. Parallel samples of membranes containing NeuS and a green fluorescent protein (GFP) chimera were compared by target analysis. The target size of this structural unit was estimated by analysis of the rate of decay of the GFP-NeuS chimera band migrating in the immunoblots. The target size of the structural unit is larger than expected for a monomer. The results of these experiments show that while the target size of the catalytic activity for K92 polysialyltransferase is larger than a monomer of NeuS, a large complex is not required for catalysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - ELECTRONS
KW - GREEN fluorescent protein
KW - ESCHERICHIA
KW - ENZYMES
KW - MONOMERS
N1 - Accession Number: 23125997; Vionnet, Justine 1 Kempner, Ellis S. 2 Vann, Willie F. 1; Email Address: wvann@helix.nih.gov; Affiliation: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892. 2: Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892.; Source Info: 11/14/2006, Vol. 45 Issue 45, p13511; Subject Term: ESCHERICHIA coli; Subject Term: ELECTRONS; Subject Term: GREEN fluorescent protein; Subject Term: ESCHERICHIA; Subject Term: ENZYMES; Subject Term: MONOMERS; Number of Pages: 6p; Document Type: Article
L3 - 10.1021/bi061486k
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ER -
TY - JOUR
ID - 106166481
T1 - Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility.
AU - Wolff TA
AU - Wilson JE
Y1 - 2006/11/15/
N1 - Accession Number: 106166481. Language: English. Entry Date: 20071005. Revision Date: 20150711. Publication Type: Journal Article; case study; CEU; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Breast Neoplasms -- Familial and Genetic
KW - Genes, BRCA
KW - Ovarian Neoplasms -- Familial and Genetic
KW - Breast Neoplasms -- Ethnology
KW - Breast Neoplasms -- Prevention and Control
KW - Breast Neoplasms -- Risk Factors
KW - Cancer Screening
KW - Disease Susceptibility
KW - Education, Continuing (Credit)
KW - Female
KW - Genetic Screening
KW - Mutation
KW - Ovarian Neoplasms -- Ethnology
KW - Ovarian Neoplasms -- Prevention and Control
KW - Ovarian Neoplasms -- Risk Factors
KW - Sequence Analysis
SP - 1759
EP - 1760
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 74
IS - 10
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Medical Officer, U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality
U2 - PMID: 17137007.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Sung Hee
AU - Seo, Geom Seog
AU - Kim, Hak Sung
AU - Woo, Sun Wook
AU - Ko, Geonil
AU - Sohn, Dong Hwan
T1 - 2′,4′,6′-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2006/11/15/
VL - 72
IS - 10
M3 - Article
SP - 1322
EP - 1333
SN - 00062952
AB - Abstract: Proliferation of hepatic stellate cells (HSCs) is central for the development of fibrosis during liver injury. We have shown previously that butein (3,4,2′,4′-tetrahydroxychalcone) suppresses myofibroblastic differentiation of rat HSCs. Our aim in this study was to determine whether a new synthetic chalcone derivative, 2′,4′,6′-tris(methoxymethoxy) chalcone (TMMC) inhibits HSC proliferation induced by serum- or platelet-derived growth factor (PDGF). TMMC significantly inhibited growth factor-induced HSC proliferation. The inhibition of PDGF-induced proliferation by TMMC was associated with the phosphatidylinositol 3-kinase-Akt-p70S6K pathways. TMMC induced the expression of heme oxygenase 1 (HO-1) in HSCs. Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of TMMC on PDGF-induced proliferation is mediated by HO-1. Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs. These results demonstrate that TMMC preferentially activates ERK and that this activation leads to the transcriptional activation of AP-1 and consequently to HO-1 expression. HO-1 expression might be responsible for the antiproliferative effect of TMMC on HSCs. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - PROTEIN kinases
KW - CELLULAR growth
KW - CYTOKINES
KW - 2′
KW - 2′,4′,6′-Tris(methoxymethoxy) chalcone
KW - 2′,4′,6′-tris(methoxymethoxy) chalcone ( TMMC )
KW - 4′
KW - 6′-Tris(methoxymethoxy) chalcone
KW - 6′-tris(methoxymethoxy) chalcone ( TMMC )
KW - activator protein-1 ( AP-1 )
KW - AP-1
KW - diethyl maleate ( DEM )
KW - ERK
KW - extracellular signal-regulated kinase ( ERK )
KW - GSH
KW - heme oxygenase-1 ( HO-1 )
KW - Hepatic stellate cell
KW - hepatic stellate cell ( HSC )
KW - mitogen-activated protein kinase ( MAPK )
KW - mitogen-activated protein kinase kinase ( MEK )
KW - phosphatidylinositol 3-kinase ( PI3K )
KW - tin protoporphyrin ( SnPP )
N1 - Accession Number: 22794535; Lee, Sung Hee 1 Seo, Geom Seog 2 Kim, Hak Sung 1 Woo, Sun Wook 3 Ko, Geonil 1 Sohn, Dong Hwan 1; Email Address: dhsohn@wonkwang.ac.kr; Affiliation: 1: College of Pharmacy, Medicinal Resources Research Institute, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea 2: Institute of Digestive and Disease, Wonkwang University School of Medicine, Iksan, Jeonbuk 570-749, Republic of Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Nov2006, Vol. 72 Issue 10, p1322; Subject Term: CELL proliferation; Subject Term: PROTEIN kinases; Subject Term: CELLULAR growth; Subject Term: CYTOKINES; Author-Supplied Keyword: 2′; Author-Supplied Keyword: 2′,4′,6′-Tris(methoxymethoxy) chalcone; Author-Supplied Keyword: 2′,4′,6′-tris(methoxymethoxy) chalcone ( TMMC ); Author-Supplied Keyword: 4′; Author-Supplied Keyword: 6′-Tris(methoxymethoxy) chalcone; Author-Supplied Keyword: 6′-tris(methoxymethoxy) chalcone ( TMMC ); Author-Supplied Keyword: activator protein-1 ( AP-1 ); Author-Supplied Keyword: AP-1; Author-Supplied Keyword: diethyl maleate ( DEM ); Author-Supplied Keyword: ERK; Author-Supplied Keyword: extracellular signal-regulated kinase ( ERK ); Author-Supplied Keyword: GSH; Author-Supplied Keyword: heme oxygenase-1 ( HO-1 ); Author-Supplied Keyword: Hepatic stellate cell; Author-Supplied Keyword: hepatic stellate cell ( HSC ); Author-Supplied Keyword: mitogen-activated protein kinase ( MAPK ); Author-Supplied Keyword: mitogen-activated protein kinase kinase ( MEK ); Author-Supplied Keyword: phosphatidylinositol 3-kinase ( PI3K ); Author-Supplied Keyword: tin protoporphyrin ( SnPP ); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bcp.2006.08.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105847230
T1 - Progress with a purpose: eliminating suffering and death due to cancer.
AU - von Eschenbach AC
Y1 - 2006/11/15/
N1 - Accession Number: 105847230. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8712059.
KW - Neoplasms -- Prevention and Control
KW - Stress, Psychological -- Prevention and Control
KW - Cause of Death
KW - Drug Therapy -- Methods
KW - Drug Therapy -- Trends
KW - Neoplasms -- Mortality
KW - Neoplasms -- Psychosocial Factors
KW - Pain -- Prevention and Control
KW - Pain -- Psychosocial Factors
KW - Research, Medical -- Methods
KW - Research, Medical -- Trends
KW - Stress, Psychological -- Psychosocial Factors
KW - Human
SP - 1691
EP - 1696
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 20
IS - 13
CY - Norwalk, Connecticut
PB - UBM Medica
SN - 0890-9091
AD - Acting Commissioner, Food and Drug Administration, Rockville, Maryland
U2 - PMID: 17175745.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tareke, Eden
AU - Twaddle, Nathan C.
AU - McDaniel, L. Patrice
AU - Churchwell, Mona I.
AU - Young, John F.
AU - Doerge, Daniel R.
T1 - Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2006/11/15/
VL - 217
IS - 1
M3 - Article
SP - 63
EP - 75
SN - 0041008X
AB - Abstract: Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells and carcinogenic in rodents. AA is also formed in many commonly consumed starchy foods during cooking. Our previous toxicokinetic investigations of AA and its important genotoxic metabolite, glycidamide (GA), in rodents showed that AA is highly bioavailable from oral routes of administration, is widely distributed to tissues and that the dietary route, in particular, favors metabolism to GA. Measurements of DNA adducts in many tissues supported the hypothesis that AA is carcinogenic in rodent bioassays through metabolism to GA. The current investigation describes the development and validation of methodology for measuring hemoglobin (Hb) adducts with AA and GA in the same rodents previously used for toxicokinetic and DNA adduct measurements. The goal was to investigate possible relationships between these circulating biomarkers of exposure and serum toxicokinetic parameters for AA and GA and tissue GA-DNA adducts in rodents from both single and repeated dosing with AA. Significant correlations were observed between GA-Hb and liver GA-DNA adducts for either single or multiple dosing regimens with AA. Using available GA-Hb adduct data, empirical and allometric relationships permitted estimation of liver DNA adducts in humans in the range of 0.06–0.3 adducts/108 nucleotides. This approach may prove useful in extrapolating human cancer risks from findings in rodent bioassays. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLAMIDE
KW - DNA
KW - ACRYLATES
KW - HEMOGLOBIN polymorphisms
KW - Acrylamide
KW - DNA adduct
KW - Glycidamide
KW - Hemoglobin adduct
KW - Toxicokinetics
N1 - Accession Number: 22934729; Tareke, Eden 1 Twaddle, Nathan C. 1 McDaniel, L. Patrice 1 Churchwell, Mona I. 1 Young, John F. 1 Doerge, Daniel R.; Email Address: daniel.doerge@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Nov2006, Vol. 217 Issue 1, p63; Subject Term: ACRYLAMIDE; Subject Term: DNA; Subject Term: ACRYLATES; Subject Term: HEMOGLOBIN polymorphisms; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: Glycidamide; Author-Supplied Keyword: Hemoglobin adduct; Author-Supplied Keyword: Toxicokinetics; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.taap.2006.07.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sung II Yoon
AU - Logsdon, Naomi J.
AU - Sheikh, Faruk
AU - Donnelly, Raymond P.
AU - Walter, Mark R.
T1 - Conformational Changes Mediate Interleukin-10 Receptor 2 (IL-10R2) Binding to IL-10 and Assembly of the Signaling Complex.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/11/17/
VL - 281
IS - 46
M3 - Article
SP - 35088
EP - 35096
SN - 00219258
AB - Interleukin-10 receptor 2 (IL-10R2) is a critical component of the IL-10-IL-10R1IL-10R2 complex which regulates IL-10-mediated immunomodulatory responses. The ternary IL-10 signaling complex is assembled in a sequential order with the IL-10-IL-10R1 interaction occurring first followed by engagement of the IL-10R2 chain. In this study we map the IL-10R2 binding site on IL-10 using surface plasmon resonance and cell-based assays. Critical IL-10R2 binding residues are located in helix A adjacent to the previously identified IL-10R1 recognition surface. Interestingly, IL-10R2 binding residues located in the N-terminal end of helix A exhibit large structural differences between unbound cIL-10 and cIL-10-IL-10R1 crystal structures. This suggests IL-10R1-induced conformational changes regulate IL-10R2 binding and assembly of the ternary IL-10-IL-10RFIL-10R2 complex. The basic mechanistic features of the assembly process are likely shared by six additional class-2 cytokines (viral IL-10s, IL-22, IL-26, IL-28A, 1L28B, and IL-29) to promote IL-10R2 binding to six additional receptor complexes. These studies highlight the importance of structure in regulating low affinity protein-protein interactions and IL-b signal transduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERLEUKIN-10
KW - CYTOKINES
KW - IMMUNOLOGICAL adjuvants
KW - PROTEIN-protein interactions
KW - SURFACE plasmon resonance
KW - MICROBIAL genetics
N1 - Accession Number: 23420031; Sung II Yoon 1,2 Logsdon, Naomi J. 2 Sheikh, Faruk 3 Donnelly, Raymond P. 3 Walter, Mark R. 1,2; Email Address: walter@uab.edu; Affiliation: 1: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2: Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294 3: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 11/17/2006, Vol. 281 Issue 46, p35088; Subject Term: INTERLEUKIN-10; Subject Term: CYTOKINES; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: PROTEIN-protein interactions; Subject Term: SURFACE plasmon resonance; Subject Term: MICROBIAL genetics; Number of Pages: 9p; Illustrations: 2 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M606791200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Churchwell, Mona I.
AU - Beland, Frederick A.
AU - Doerge, Daniel R.
T1 - Quantification of O 6-methyl and O 6-ethyl deoxyguanosine adducts in C57BL/6N/Tk +/− mice using LC/MS/MS
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/11/21/
VL - 844
IS - 1
M3 - Article
SP - 60
EP - 66
SN - 15700232
AB - Abstract: The carcinogenicity of many alkylating agents is derived from their ability to form persistent DNA adducts that induce mutations. This paper presents and validates methodology, based on LC with tandem mass spectrometry, for the separate or concurrent quantification by isotope dilution of O 6-methyl-2′-deoxyguanosine (O 6Me-dG) and O 6-ethyl-2′-deoxyguanosine (O 6Et-dG) DNA adducts. The limits of quantification were estimated to be ≤0.2 adducts/108 nucleotides for either adduct. This sensitivity permitted evaluation of adduct levels in livers from separate groups of untreated adult C57BL/6N/Tk +/− and C57BL/6N X Sv129 mice (undetectable to 5.5±6.7 O 6Me-dG/108 nucleotides; undetectable to 0.04 O 6Et-dG/108 nucleotides). Treatment of adult C57BL/6N/Tk +/− mice with equimolar doses (342μmol/kg body weight) of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea produced adduct levels in liver of 1700±80 O 6Me-dG/108 nucleotides and 260±60 O 6Et-dG/108 nucleotides, respectively, when assessed 4h after dosing. These methods should be useful for evaluations of DNA adducts in relation to cellular processes that modify carcinogenic and toxicological responses in experimental animals and humans. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENICITY
KW - ALKYLATING agents
KW - DNA adducts
KW - MUTATION (Biology)
KW - ISOTOPE dilution analysis
KW - NUCLEOTIDES
KW - Mass spectrometry
KW - O 6-Ethyl-2′-deoxyguanosine
KW - O 6-Methyl-2′-deoxyguanosine
N1 - Accession Number: 23050870; Churchwell, Mona I. 1 Beland, Frederick A. 1 Doerge, Daniel R.; Email Address: ddoerge@nctr.fda.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Source Info: Nov2006, Vol. 844 Issue 1, p60; Subject Term: CARCINOGENICITY; Subject Term: ALKYLATING agents; Subject Term: DNA adducts; Subject Term: MUTATION (Biology); Subject Term: ISOTOPE dilution analysis; Subject Term: NUCLEOTIDES; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: O 6-Ethyl-2′-deoxyguanosine; Author-Supplied Keyword: O 6-Methyl-2′-deoxyguanosine; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.06.042
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Turnipseed, Sherri B.
AU - Clark, Susan B.
AU - Andersen, Wendy C.
AU - Karbiwnyk, Christine M.
AU - Miller, Keith E.
AU - Hurlbut, Jeffrey A.
T1 - Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography–mass spectrometry
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/11/21/
VL - 844
IS - 1
M3 - Article
SP - 127
EP - 133
SN - 15700232
AB - Abstract: Diminazene diaceturate is used as a trypanocide for cattle in tropical regions. This paper describes a LC–MS n method to confirm the presence of diminazene in bovine plasma. Bound diminazene in plasma samples was freed with dilute phosphoric acid, then concentrated on a bonded C18 SPE cartridge. The LC–MS n method utilized electrospray ionization coupled with an ion trap mass spectrometer. Ions observed in MS2 and MS3 product ion spectra, as well as those from the MS1 spectrum, were monitored. The method was validated with plasma samples fortified with diminazene diaceturate (4–100ng/mL). Diminazene was confirmed in samples fortified with diminazene diaceturate at levels of 6.4ng/mL or higher. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - LIQUID chromatography
KW - ELECTROSPRAY ionization mass spectrometry
KW - PHOSPHORIC acid
KW - MASS spectrometers
KW - Bovine plasma
KW - Diminazene diaceturate
KW - Mass spectrometry
N1 - Accession Number: 23050879; Turnipseed, Sherri B. 1; Email Address: sherri.turnipseed@fda.hhs.gov Clark, Susan B. 2 Andersen, Wendy C. 1 Karbiwnyk, Christine M. 1 Miller, Keith E. 3 Hurlbut, Jeffrey A. 4; Affiliation: 1: Animal Drugs Research Center, Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225, United States 2: Denver District Laboratory, Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225, United States 3: University of Denver, Department of Chemistry and Biochemistry, Denver, CO 80208, United States 4: Western Washington University, Department of Chemistry, Bellingham, WA 98225, United States; Source Info: Nov2006, Vol. 844 Issue 1, p127; Subject Term: BLOOD plasma; Subject Term: LIQUID chromatography; Subject Term: ELECTROSPRAY ionization mass spectrometry; Subject Term: PHOSPHORIC acid; Subject Term: MASS spectrometers; Author-Supplied Keyword: Bovine plasma; Author-Supplied Keyword: Diminazene diaceturate; Author-Supplied Keyword: Mass spectrometry; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; NAICS/Industry Codes: 325312 Phosphatic Fertilizer Manufacturing; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.07.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, Daniel Rh.
AU - Mason, Brendan W.
AU - Beer, Laura
AU - Scourfield, Simon
AU - James-Hatherill, Helen
AU - Hayes, Sara
T1 - Surveillance of influenza immunisation uptake in people aged under 65 years with chronic disease
JO - Vaccine
JF - Vaccine
Y1 - 2006/11/30/
VL - 24
IS - 49/50
M3 - Article
SP - 7027
EP - 7029
SN - 0264410X
AB - Abstract: Historically, it has been difficult to obtain population based data on the uptake of influenza immunisation in people aged under 65 years who are at risk of serious illness or death from influenza and its complications. Data obtained electronically from 96% of all practices in Wales demonstrated that uptake in this group is low, with only a quarter of eligible patients immunised. Uptake varies considerably between patient groups and between geographical areas. This suggests an opportunity for significant health gain from targeted interventions to improve uptake. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Respiratory infections
KW - Chronic diseases
KW - Preventive medicine
KW - Influenza immunisation
KW - Under 65 years of age
KW - Vaccine uptake
N1 - Accession Number: 23051662; Thomas, Daniel Rh. 1; Mason, Brendan W. 1; Email Address: brendan.mason@nphs.wales.nhs.uk; Beer, Laura 2; Scourfield, Simon 2; James-Hatherill, Helen 2; Hayes, Sara 3; Affiliations: 1: National Public Health Service for Wales Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK; 2: Welsh Assembly Government ICT Foundation Programme, Swansea, UK; 3: National Public Health Service Mid and West Wales Health Protection Team, Swansea, UK; Issue Info: Nov2006, Vol. 24 Issue 49/50, p7027; Thesaurus Term: Virus diseases; Subject Term: Respiratory infections; Subject Term: Chronic diseases; Subject Term: Preventive medicine; Author-Supplied Keyword: Influenza immunisation; Author-Supplied Keyword: Under 65 years of age; Author-Supplied Keyword: Vaccine uptake; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.06.063
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tomashek, Kay M.
AU - Cheng Qin
AU - Hsia, Jason
AU - Iyasu, Solomon
AU - Barfield, Wanda D.
AU - Rowers, Lisa M.
T1 - Infant Mortality Trends and Differences Between American Indian/Alaska Native Infants and White Infants in the United States, 1989-1991 and 1998-2000.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2006/12//
VL - 96
IS - 12
M3 - Article
SP - 2222
EP - 2227
PB - American Public Health Association
SN - 00900036
AB - Objectives: To describe changes in infant mortality rates, including birth weight-specific rates and rates by age at death and cause. Methods: We analyzed US linked birth/infant-death data for 1989-1991 and 1998-2000 for American Indians/Alaska Native (AIAN) and White singleton infants at ≥20 weeks' gestation born to US residents. We calculated birth weight-specific infant mortality rates (deaths in each birth weight category per 1000 live births in that category), and overall and cause-specific infant mortality rates (deaths per 100000 live births) in infancy (0-364 days) and in the neonatal (0-27 days) and post-neonatal (28-364 days) periods. Results: Birth weight-specific infant mortality rates declined among AIAN and White infants across all birth weight categories, but AIAN infants generally had higher birth weight-specific infant mortality rates. Infant mortality rates declined for both groups, yet in 1998-2000, AIAN infants were still 1.7 times more likely to die than White infants. Most of the disparity was because of elevated post-neonatal mortality, especially from sudden infant death syndrome, accidents, and pneumonia and influenza. Conclusions: Although birth weight-specific infant mortality rates and infant mortality rates declined among both AIAN and White infants, disparities in infant mortality persist. Preventable causes of infant mortality identified in this analysis should be targeted to reduce excess deaths among AIAN communities. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT mortality
KW - MORTALITY
KW - INFANTS -- Death
KW - BIRTH weight
KW - DEMOGRAPHY
KW - RACE
KW - ETHNICITY
KW - FACTOR analysis
KW - UNITED States
N1 - Accession Number: 23413801; Tomashek, Kay M. 1 Cheng Qin 1 Hsia, Jason 2 Iyasu, Solomon 3 Barfield, Wanda D. 4 Rowers, Lisa M. 2; Affiliation: 1: Maternal and Infant Health Branch, Division of Reproductive Health, CDC 2: Information Technology, Statistics and Surveillance Branch, Division of Reproductive Health, CDC 3: Office of Counterterrorism and Pediatric Drug Development, Division of Pediatric Drug Development, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Md. 4: Applied Sciences Branch, Division of Reproductive Health, CDC; Source Info: Dec2006, Vol. 96 Issue 12, p2222; Subject Term: INFANT mortality; Subject Term: MORTALITY; Subject Term: INFANTS -- Death; Subject Term: BIRTH weight; Subject Term: DEMOGRAPHY; Subject Term: RACE; Subject Term: ETHNICITY; Subject Term: FACTOR analysis; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article; Full Text Word Count: 5343
L3 - 10.2105/AJPH.2004.053744
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106136197
T1 - Sobering thoughts: town hall meetings on fetal alcohol spectrum disorders.
AU - Ryan DM
AU - Bonnett DM
AU - Gass CB
Y1 - 2006/12//
N1 - Accession Number: 106136197. Language: English. Entry Date: 20070817. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. NLM UID: 1254074.
KW - Fetal Alcohol Syndrome -- Prevention and Control
KW - Health and Welfare Planning
KW - Health Policy
KW - Abnormalities, Drug-Induced -- Etiology
KW - Abnormalities, Drug-Induced -- Prevention and Control
KW - Abnormalities, Multiple -- Etiology
KW - Abnormalities, Multiple -- Prevention and Control
KW - Adult
KW - Alcohol Drinking
KW - Child
KW - Child Welfare
KW - Consumer Participation
KW - Female
KW - Fetal Alcohol Syndrome -- Diagnosis
KW - Fetal Alcohol Syndrome -- Epidemiology
KW - Fetal Alcohol Syndrome -- Physiopathology
KW - Health Education
KW - Infant, Newborn
KW - Needs Assessment
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Social Responsibility
KW - Substance Abuse and Mental Health Services Administration
KW - United States
SP - 2098
EP - 2101
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 96
IS - 12
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Prenatal exposure to alcohol is one of the leading causes of preventable birth defects and developmental disabilities. During the past 30 years, fetal alcohol spectrum disorders (FASD), including fetal alcohol syndrome, have gradually begun to attract attention. However, awareness and understanding of the disorders remain low, and people who are affected are seriously underserved. The FASD Center for Excellence held a series of town hall meetings in 2002 and 2003 to gauge the issues surrounding FASD nationwide. On the basis of its findings, the center proposed a series of recommendations to begin to remedy some of the deficiencies that were identified.
SN - 0090-0036
AD - Fetal Alcohol Spectrum Disorders Center for Excellence, Substance Abuse and Mental Health Services Administration, Rockville, Md.
U2 - PMID: 17077397.
DO - 10.2105/AJPH.2005.062729
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Green, Brett James
AU - O'Meara, Timothy
AU - Sercombe, Jason Kingsley
AU - ToveyL, Euan Roger
T1 - MEASUREMENT OF PERSONAL EXPOSURE TO OUTDOOR AEROMYCOTA IN NORTHERN NEW SOUTH WALES, AUSTRALIA.
JO - Annals of Agricultural & Environmental Medicine
JF - Annals of Agricultural & Environmental Medicine
Y1 - 2006/12//
VL - 13
IS - 2
M3 - Article
SP - 225
EP - 234
SN - 12321966
AB - Aerobiological sampling traditionally uses a volumetric spore trap located in a fixed position to estimate personal exposure to airborne fungi. In this study, the number and identity of fungi inhaled by human subjects (n=34), wearing Intra-nasal air samplers (INASs), was measured over 2-hour periods in an outdoor community setting, and compared to fungal counts made with a Burkard spore trap and Institute of Occupational Medicine personal filter air samplers (IOMs). All sampling devices were in close proximity and located in an outdoor environment in Casino, northern New South Wales, Australia. Using INASs, the most prevalent fungi inhaled belonged to soil or vegetation borne spores of Alternaria, Arthrinium, Bipolaris, Cladosporium, Curvularia, Epicoccum, Exserohilum, Fusarium, Pithomyces, Spegazzinia and Tetraploa species, Xylariaceae ascospores, in addition to hyphal fragments. These results showed that inhaled fungal exposure in most people varied in a 2-fold range with 10-fold outliers. In addition, the INASs and personal air filters agreed more with each other than with Burkard spore trap counts (r=0.74, p<0.0001). These findings further support a new paradigm of personal fuogal exposure, which implicates the inhalation of a spectrum of fungi more closely associated with soil or vegetation borne mycoflora and hyphal fragments than what is collected by stationary spore traps in the same geographic region. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Agricultural & Environmental Medicine is the property of Instytut Medycyny WSI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungi imperfecti
KW - Molds (Fungi)
KW - Tuberculariaceae
KW - Allergens
KW - Fusarium oxysporum
KW - Fungi -- Hyphae
KW - Epicoccum
KW - Plant spores
KW - Australia
KW - airborne fungi
KW - allergen
KW - conidia
KW - hyphae
KW - mould
N1 - Accession Number: 24136359; Green, Brett James 1,2,3; Email Address: Brett.Green@cdc.hhs.gov; O'Meara, Timothy 4; Sercombe, Jason Kingsley 2; ToveyL, Euan Roger 2; Affiliations: 1: Department of Medicine, The University of Sydney, NSW, Australia; 2: Woolcock Institute of Medical Research, Sydney, NSW, Australia; 3: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS. 4020, Morgantown, WV. 26505-2888; 4: CSIRO Health Science and Nutrition, Victoria, Australia; Issue Info: 2006, Vol. 13 Issue 2, p225; Thesaurus Term: Fungi imperfecti; Thesaurus Term: Molds (Fungi); Thesaurus Term: Tuberculariaceae; Thesaurus Term: Allergens; Subject Term: Fusarium oxysporum; Subject Term: Fungi -- Hyphae; Subject Term: Epicoccum; Subject Term: Plant spores; Subject: Australia; Author-Supplied Keyword: airborne fungi; Author-Supplied Keyword: allergen; Author-Supplied Keyword: conidia; Author-Supplied Keyword: hyphae; Author-Supplied Keyword: mould; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aguilera, Nadine S. I.
AU - Jian Chen
AU - Bijwaard, Karen E.
AU - Director-Myska, Alison E.
AU - Barekman, Carol L.
AU - Millward, Carl
AU - Lichy, Jack
AU - Abbondanzo, Susan L.
T1 - Gene Rearrangement and Comparative Genomic Hybridization Studies of Classic Hodgkin Lymphoma Expressing T-Cell Antigens.
JO - Archives of Pathology & Laboratory Medicine
JF - Archives of Pathology & Laboratory Medicine
Y1 - 2006/12//
VL - 130
IS - 12
M3 - Article
SP - 1772
EP - 1779
PB - College of American Pathologists
SN - 00039985
AB - Context.—Reed-Sternberg cells in classic Hodgkin lymphoma are enigmatic and difficult to study because they are so sparse. Tissue microdissection allows for the isolation of single Reed-Sternberg cells. Isolated Reed-Sternberg cells show clonal immunoglobulin gene rearrangement indicating a B-cell origin. Rarely, Reed-Sternberg cells in classic Hodgkin lymphoma express T-cell antigens, suggesting a possible T-cell origin. Objective.—To determine whether there is a difference in genotype between classic Hodgkin lymphoma and classic Hodgkin lymphoma expressing T-cell antigens and to document T-cell clonality. Design.—We studied 4 cases of Hodgkin lymphoma with a characteristic phenotype and immunoreactivity for CD2 and CD3. Single CD30+ Reed-Sternberg cells from each case were isolated by laser capture microdissection for immunoglobulin heavy chain and T-cell receptor-γ genes by polymerase chain reaction studies. Comparative genomic hybridization was performed in all cases. Results.—Two of 4 cases showed clonal rearrangement of the T-cell receptor-γ; none showed immunoglobulin heavy chain rearrangement. Two control cases were negative for T cell receptor-γ but 1 showed immunoglobulin heavy chain rearrangement. Comparative genomic hybridization analysis revealed significant overlap in genomic alteration in Hodgkin lymphoma cases regardless of genotype or phenotype and several regions of imbalance specific to CD3+ Hodgkin lymphoma cases. All patients are alive with no evidence of disease from 10 to 44 months. Conclusions.—Our findings suggest that a T-cell phenotype classic Hodgkin lymphoma can be supported by genotypic studies and that there may be cytogenetic differences between classic Hodgkin lymphoma and Hodgkin lymphoma expressing T-cell antigens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Pathology & Laboratory Medicine is the property of College of American Pathologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HODGKIN'S disease
KW - IMMUNOGLOBULINS
KW - ANTIBODY diversity
KW - T-cell receptor genes
KW - HYBRIDIZATION -- Molecular aspects
KW - HUMAN immunogenetics
N1 - Accession Number: 24292518; Aguilera, Nadine S. I. 1; Email Address: aguilera@afip.osd.mil Jian Chen 1,2 Bijwaard, Karen E. 3,4 Director-Myska, Alison E. 3,5 Barekman, Carol L. 1,6 Millward, Carl 7,8 Lichy, Jack 9 Abbondanzo, Susan L. 1,10; Affiliation: 1: Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC. 2: Kaiser Permanente Medical Center, Oakland, Calif. 3: Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC. 4: FDA/CDRH/OIVD, Rockville, Md. 5: Camber Corporation, Alexandria, Va. 6: Ameripath, Southwest Florida, Fort Myers, Fla. 7: Department of Soft Tissue, Armed Forces Institute of Pathology, Washington, DC. 8: Mills-Peninsula Health Services, Burlingame, Calif. 9: Veterans Administration Hospital, Washington, DC. 10: Hematology/CBER, Food and Drug Administration, Bethesda, Md.; Source Info: Dec2006, Vol. 130 Issue 12, p1772; Subject Term: HODGKIN'S disease; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIBODY diversity; Subject Term: T-cell receptor genes; Subject Term: HYBRIDIZATION -- Molecular aspects; Subject Term: HUMAN immunogenetics; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shin, Jae-Ho
AU - Moon, Hyun Ju
AU - Kang, Il Hyun
AU - Kim, Tae Sung
AU - Kim, In Young
AU - Park, In Sook
AU - Kim, Hyung Sik
AU - Jeung, Eui Bae
AU - Han, Soon-Young
T1 - Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the “Enhanced OECD Test Guideline No. 407” to detect endocrine effects.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2006/12//
VL - 80
IS - 12
M3 - Article
SP - 797
EP - 803
SN - 03405761
AB - We performed a 28-day repeated-dose toxicity study of ketoconazole, a widely used an antimycotic drug, based on the draft protocol of the “Enhanced OECD Test Guideline 407” (Enhanced TG407) to investigate whether ketoconazole has endocrine-mediated properties according to this assay. Seven-week-old SD rats were administered with ketoconazole daily by oral gavage at doses of 0, 6.25, 25 or 100 mg kg−1 day−1 for at least 28 days. The ketoconazole-treated male rats showed reduction of epididymis and accessory sex organ weights, spermatid retention in the seminiferous tubules, decrease of testosterone and increases of estradiol, luteinizing hormone (LH) and follicular stimulating hormone (FSH). A prolongation of the estrous cycle and increases of estradiol, LH and FSH were observed in the treated female rats. Thyroxin and triiodothyronine were decreased and thyroid-stimulating hormone was increased in both sexes; however, there were no compound-related microscopic lesions in the thyroid gland or changes in the thyroid weight. The endocrine-related effects of ketoconazole could be detected by the parameters examined in the present study based on the Organization for Economic Cooperation and Development (OECD) protocol, suggesting that the Enhanced TG407 protocol should be a suitable screening test for detection of endocrine-mediated effects of chemicals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KETOCONAZOLE
KW - EPIDIDYMIS
KW - LUTEINIZING hormone
KW - ESTRADIOL
KW - THYROTROPIN
KW - MEDICAL protocols
KW - Endocrine disruptors
KW - Enhanced OECD Test Guideline 407
KW - Ketoconazole
KW - Rat
KW - ORGANISATION for Economic Co-operation & Development
N1 - Accession Number: 23262451; Shin, Jae-Ho 1 Moon, Hyun Ju 1 Kang, Il Hyun 1 Kim, Tae Sung 1 Kim, In Young 1 Park, In Sook 2 Kim, Hyung Sik 3 Jeung, Eui Bae 4 Han, Soon-Young 1; Email Address: soonyoungh@kfda.go.kr; Affiliation: 1: Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Korea 2: Department of Pharmacology, Korea Food and Drug Administration, Seoul 122-704, Korea 3: Department of Toxicology, College of Pharmacy, Pusan National University, Pusan 609-735, Korea 4: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Chungbuk 361-763, Korea; Source Info: Dec2006, Vol. 80 Issue 12, p797; Subject Term: KETOCONAZOLE; Subject Term: EPIDIDYMIS; Subject Term: LUTEINIZING hormone; Subject Term: ESTRADIOL; Subject Term: THYROTROPIN; Subject Term: MEDICAL protocols; Author-Supplied Keyword: Endocrine disruptors; Author-Supplied Keyword: Enhanced OECD Test Guideline 407; Author-Supplied Keyword: Ketoconazole; Author-Supplied Keyword: Rat; Company/Entity: ORGANISATION for Economic Co-operation & Development; NAICS/Industry Codes: 919110 International and other extra-territorial public administration; NAICS/Industry Codes: 928120 International Affairs; Number of Pages: 7p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1007/s00204-006-0116-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Tosatto, RJ;
T1 - Medical Reserve Corps response in an evolving event
CT - Medical Reserve Corps response in an evolving event
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 2006/12/01/
VL - 41
IS - Dec
SP - pi
EP - 41
AD - Off Surg Gen, 5600 Fishers Lane, Room 180C-14, Rockville, MD 20857, USA robert.tosatto@hhs.gov
N1 - Accession Number: 44-07297; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacology; Sociology, Economics and Ethics
N2 - The Medical Reserve Corps (MRC) program, housed in the Office of the US Surgeon General, is a national system of community-based teams of medical and public health volunteers who strengthen local public health infrastructure and improve emergency preparedness. The concept and evolution of the MRC is introduced, different organizational models for MRC units are described, and the key roles that pharmacists can play in the establishment, implementation and maintenance of MRC units are highlighted. Challenges and lessons-learned involved in responding to local emergency events, as well as events of national significance, are discussed. A key finding is that local partnerships and collaborations between the various community response partners (e.g., health professionals, public health departments, emergency service agencies, and hospitals) are essential in order to make communities healthier and safer. Learning objectives: 1. Describe the Medical Reserve Corps concept. 2. Explain how MRC models differ. 3. Identify the roles for MRC units and members in evolving emergency situations. Self-assessment questions: True or False: 1. A local pharmacist could play a key role in the performance of MRC activities. 2. MRC units will deploy within 12 hours in the event of a national emergency. 3. MRC members are identified, credentialed, trained and prepared in advance of an emergency. Answers: 1 (T); 2 (F); 3 (T)
KW - ASHP meeting abstracts--emergency services;
KW - Strategic planning--emergency services;
KW - Interventions--emergency services;
KW - Emergency services--ASHP meeting abstracts;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
TY - GEN
AU - Bishop, BM;
T1 - Pediatric issues in emergency preparedness and response
CT - Pediatric issues in emergency preparedness and response
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
Y1 - 2006/12/01/
VL - 41
IS - Dec
SP - pi
EP - 40
AD - Sells Indian Hosp, POB 548, Sells, AZ 85634, USA bradley.bishop@ihs.gov
N1 - Accession Number: 44-07296; Language: English; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Pharmacology; Institutional Pharmacy PracticeSociology, Economics and Ethics
N2 - Pediatric patients present a variety of issues during any emergency or disaster response. Being prepared to handle the needs of pediatric patients is critical to any emergency or disaster response plan. Potential pediatric issues include but are not limited to dosing calculations and guidelines, body weight estimation, medication reconstitution and storage, patient and parent/caregiver education, logistical issues, psychosocial issues, and appropriate dosing measures. By utilizing prepared dosing guidelines and protocols, some of these issues may be minimized or streamlined, resulting in an increase in pediatric patient safety and effective treatment. Learning objectives: 1. Describe at least two potential pediatric issues in an emergency or disaster response situation. 2. Utilize pre-printed dosing cards to calculate pediatric dosages for treatment of nerve agent, biologic, and chemical exposure. 3. Describe the benefits of including pediatric issues in emergency preparedness and response planning. Self-assessment questions: 1. What is the appropriate doxycycline dosage for an 11-month old 8 kg patient requiring prophylaxis for exposure to anthrax? (A) 18 mg PO BID, (B) 100 mg PO BID, (C) doxycyline is contraindicated in pediatric patients. 2. True or False: Dosing cards are an exact method of calculating dosages and should always replace individualized weight-based dosing. 3. True or False: No special considerations are required for pediatric patients in an emergency situation. Answers: 1. (A); 2. (F); 3. (F)
KW - ASHP meeting abstracts--emergency services;
KW - Pediatrics--emergency services;
KW - Strategic planning--disasters;
KW - Protocols--algorithms;
KW - Emergency services--ASHP meeting abstracts;
KW - Disasters--strategic planning;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Smith, Derek R.
AU - Adachi, Yasuko
AU - Mihashi, Mutsuko
AU - Ueno, Chiaki
AU - Ishitake, Tatsuya
T1 - TOBACCO SMOKING HABITS AMONG A CROSS-SECTION OF RURAL JAPANESE NURSES.
JO - Australian Journal of Advanced Nursing
JF - Australian Journal of Advanced Nursing
Y1 - 2006/12//Dec2006/Feb2007
VL - 24
IS - 2
M3 - Article
SP - 33
EP - 37
PB - Australian Nursing & Midwifery Federation
SN - 08130531
AB - Background: Despite a high community smoking rate, few investigations of tobacco usage among Japanese nurses have been conducted in rural areas, particularly those in the southern islands. Aim: The aim of this research was to investigate the epidemiology of tobacco smoking among a previously understudied group of rural Japanese nurses. Design: A self-reporting questionnaire was adapted from previous investigations and distributed to a complete cross-section of 1162 nurses from a large teaching hospital in southern Japan (response rate: 74.0%). Results: A total of 10.9% (95% Confidence Interval: 9.0-13.2) were current smokers, with a further 2.9% (95% CI: 2.0-4.3) being ex-smokers. When stratified by gender, the prevalence of smoking was 10.8% (95% CI: 8.9-13.1) among females, and 18.7% (95% CI: 6.6-43.0) among males. The median number was 10.0 cigarettes per day for a period of 10.0 years. When stratified by age, the highest smoking prevalence (16.4%) was observed among nurses aged between 45 and 50 years. In relation to career length, the highest smoking prevalence (13.3%) was demonstrated among those who had worked between 6 and 10 years. Conclusions: Overall, our study suggests that around 11% of rural nurses in southern Japan currently smoke tobacco. When stratified by gender however, the prevalence among male nurses was almost double that of their female counterparts. Although interventions to reduce smoking are clearly needed in this region, interventions will need to consider the underlying social and cultural motivations for tobacco usage among Japanese people, in general. [ABSTRACT FROM AUTHOR]
AB - Copyright of Australian Journal of Advanced Nursing is the property of Australian Nursing & Midwifery Federation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - RURAL nurses
KW - CIGARETTE smokers
KW - MALE nurses
KW - TEACHING hospitals
KW - JAPAN
KW - epidemiology
KW - Japan
KW - nurse
KW - smoking
KW - tobacco
N1 - Accession Number: 24084778; Smith, Derek R. 1; Email Address: smith@h.jniosh.go.jp Adachi, Yasuko 2 Mihashi, Mutsuko 3 Ueno, Chiaki 4 Ishitake, Tatsuya 5; Affiliation: 1: Researcher, International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan 2: Deputy Chief Nurse, Department of Nursing, Kurume University Hospital Kurume, Japan 3: Associate Professor, Kurume University School of Nursing, Kurume, Japan 4: Department of Nursing, Kurume University Hospital, Kurume, Japan 5: Professor, Department of Environmental Medicine, Kurume University School of Medicine, Kurume, Japan; Source Info: Dec2006/Feb2007, Vol. 24 Issue 2, p33; Subject Term: SMOKING; Subject Term: RURAL nurses; Subject Term: CIGARETTE smokers; Subject Term: MALE nurses; Subject Term: TEACHING hospitals; Subject Term: JAPAN; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: Japan; Author-Supplied Keyword: nurse; Author-Supplied Keyword: smoking; Author-Supplied Keyword: tobacco; Number of Pages: 5p; Document Type: Article
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DB - aph
ER -
TY - JOUR
ID - 106257998
T1 - Tobacco smoking habits among a cross-section of rural Japanese nurses.
AU - Smith DR
AU - Adachi Y
AU - Mihashi M
AU - Ueno C
AU - Ishitake T
Y1 - 2006/12//Dec2006/Feb2007
N1 - Accession Number: 106257998. Language: English. Entry Date: 20070330. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Supplement Title: Dec2006/Feb2007. Journal Subset: Australia & New Zealand; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed. NLM UID: 8409358.
KW - Nurses -- Japan
KW - Smoking -- Epidemiology -- Japan
KW - Academic Medical Centers
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Confidence Intervals
KW - Convenience Sample
KW - Cross Sectional Studies
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Fisher's Exact Test
KW - Japan
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Rural Areas
KW - Self Report
KW - Sex Factors
KW - Human
SP - 33
EP - 37
JO - Australian Journal of Advanced Nursing
JF - Australian Journal of Advanced Nursing
JA - AUST J ADV NURS
VL - 24
IS - 2
CY - Melbourne,
PB - Australian Nursing & Midwifery Federation
AB - BACKGROUND: Despite a high community smoking rate, few investigations of tobacco usage among Japanese nurses have been conducted in rural areas, particularly those in the southern islands. AIM: The aim of this research was to investigate the epidemiology of tobacco smoking among a previously understudied group of rural Japanese nurses. DESIGN: A self-reporting questionnaire was adapted from previous investigations and distributed to a complete cross-section of 1162 nurses from a large teaching hospital in southern Japan (response rate: 74.0%). RESULTS: A total of 10.9% (95% Confidence Interval: 9.0-13.2) were current smokers, with a further 2.9% (95% CI: 2.0-4.3) being ex-smokers. When stratified by gender, the prevalence of smoking was 10.8% (95% CI: 8.9-13.1) among females, and 18.7% (95% CI: 6.6-43.0) among males. The median number was 10.0 cigarettes per day for a period of 10.0 years. When stratified by age, the highest smoking prevalence (16.4%) was observed among nurses aged between 45 and 50 years. In relation to career length, the highest smoking prevalence (13.3%) was demonstrated among those who had worked between 6 and 10 years. CONCLUSIONS: Overall, our study suggests that around 11% of rural nurses in southern Japan currently smoke tobacco. When stratified by gender however, the prevalence among male nurses was almost double that of their female counterparts. Although interventions to reduce smoking are clearly needed in this region, interventions will need to consider the underlying social and cultural motivations for tobacco usage among Japanese people, in general.
SN - 0813-0531
AD - International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan. smith@h.jniosh.go.jp
U2 - PMID: 17285834.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Geronilla, Kenneth
AU - Wu, John Z.
AU - Baker, B.A.
AU - Cutlip, Robert G.
T1 - Characterization of isometric contractions of rat skeletal muscle in vivo: Duty cycle effects.
JO - Bio-Medical Materials & Engineering
JF - Bio-Medical Materials & Engineering
Y1 - 2006/12//
VL - 16
IS - 6
M3 - Article
SP - 369
EP - 380
PB - IOS Press
SN - 09592989
AB - Many work related injuries stem from the exertion of skeletal muscle forces over an extended period of time. Musculoskeletal injury can be caused by muscle's inability to maintain force during occupational exposure. The goal of the present study is to test how various rest times (duty cycles) between long isometric contractions will affect decrements in force, and develop a model that characterizes force decrements due to skeletal muscle fatigue. All tests were performed in vivo on the tibialis anterior muscle of anesthetized Sprague–Dawley rats. Animals were randomly assigned to either a 10 second (N=8), 1 minute (N=8), or 5 minute (N=8) duty cycle group. All animals were then subjected to 7 isometric contractions (duration of 2.8 seconds). A model was constructed to characterize forces changes over the duration of a contraction and over multiple contractions. The model consisted of a power law and an exponential component; these two components were combined by using an exponential weighting function. Overall, the combination of a power law and exponential model with a weighting function satisfactorily characterized the changes in isometric force for the 10 second duty cycle, but a simpler exponential model could be used where longer duty cycles are performed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bio-Medical Materials & Engineering is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLE contraction
KW - CONTRACTILITY (Biology)
KW - MUSCULOSKELETAL system -- Wounds & injuries
KW - ISOMETRIC exercise
KW - FATIGUE
KW - FORCE & energy
KW - cyclic
KW - injuries
KW - isometric contractions
KW - modeling
KW - Skeletal muscle
N1 - Accession Number: 23247960; Geronilla, Kenneth Wu, John Z. Baker, B.A. Cutlip, Robert G. 1; Email Address: RGC8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: 2006, Vol. 16 Issue 6, p369; Subject Term: MUSCLE contraction; Subject Term: CONTRACTILITY (Biology); Subject Term: MUSCULOSKELETAL system -- Wounds & injuries; Subject Term: ISOMETRIC exercise; Subject Term: FATIGUE; Subject Term: FORCE & energy; Author-Supplied Keyword: cyclic; Author-Supplied Keyword: injuries; Author-Supplied Keyword: isometric contractions; Author-Supplied Keyword: modeling; Author-Supplied Keyword: Skeletal muscle; Number of Pages: 12p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DB - aph
ER -
TY - JOUR
AU - Wang, Hsiaoling
AU - Del Grosso, Alfred V.
AU - May, Joan C.
T1 - Determination of benzethonium chloride in anthrax vaccine adsorbed by HPLC
JO - Biologicals
JF - Biologicals
Y1 - 2006/12//
VL - 34
IS - 4
M3 - Article
SP - 257
EP - 263
SN - 10451056
AB - Abstract: A novel and sensitive HPLC method for the determination of benzethonium chloride (BZC) in anthrax vaccine was developed. Adjuvant Alhydrogel was removed by syringe filter after a simple sample pretreatment—acidification prior to injection. Chromatography was performed by isocratic reverse phase separation with methanol/262mM ammonium acetate (80/20, v/v) on an endcapped C18 column with diode array detector (DAD). The method showed excellent recovery (100±1.5%). The results indicated that this method could accurately determine BZC at the limit of detection (LOD) of 0.5ppm and the limit of quantitation (LOQ) of 1.5ppm with dynamic range up to 100ppm. The comparison of analysis between new HPLC and old titrimetric methods is also reported. The HPLC method is proven to be more accurate and precise with much less vaccine sample and human labor required. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREVENTIVE medicine
KW - BACTERIAL diseases
KW - IMMUNOLOGICAL adjuvants
KW - CHROMATOGRAPHIC analysis
KW - Anthrax vaccine
KW - Benzethonium chloride
KW - HPLC
N1 - Accession Number: 23161096; Wang, Hsiaoling; Email Address: wangh@cber.fda.gov Del Grosso, Alfred V. 1 May, Joan C. 1; Affiliation: 1: Laboratory of Analytical Chemistry, Office of Vaccine Research and Review, Center of Biological Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM-406, Rockville, MD 20852, USA; Source Info: Dec2006, Vol. 34 Issue 4, p257; Subject Term: PREVENTIVE medicine; Subject Term: BACTERIAL diseases; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Anthrax vaccine; Author-Supplied Keyword: Benzethonium chloride; Author-Supplied Keyword: HPLC; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biologicals.2005.11.004
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DB - aph
ER -
TY - JOUR
AU - Mohan, K.V.K.
AU - Glass, R.I.
AU - Atreya, C.D.
T1 - Comparative molecular characterization of gene segment 11-derived NSP6 from lamb rotavirus LLR strain used as a human vaccine in China
JO - Biologicals
JF - Biologicals
Y1 - 2006/12//
VL - 34
IS - 4
M3 - Article
SP - 265
EP - 272
SN - 10451056
AB - Abstract: Sequence-length polymorphism is known for rotavirus genetic segment 11 (encodes non-structural protein, NSP6). With the exception of 11 strains that have the coding potential for a 98-residue NSP6, majority of the strains have the potential for a 92-residue NSP6. In nine strains, the coding potential for this protein is even shorter. This report focuses on the NSP6 gene nucleotide sequence of Lanzhou Lamb Rotavirus (LLR) strain and its comparative molecular characterization. The LLR strain is a G10 P12 type, which is in use as a licensed human vaccine in China. The LLR NSP6 was compared with 56 other rotaviral NSP6 sequences including a rhesus strain (RRV) available in the database. Analyses indicate that while RRV-NSP6 belongs to the majority (92-residue) group, the LLR NSP6 belongs to the 98-residue group. When the rotavirus NSP6 protein was expressed in cells as GFP fusion protein from human, simian and the LLR strains, they all demonstrated punctate cytoplasmic distribution and, contrary to the computer-aided prediction, the NSP6 did not undergo phosphorylation, which in itself is a novel observation for the rotavirus NSP6. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases
KW - GREEN fluorescent protein
KW - GENETIC polymorphisms
KW - NUCLEIC acids -- Analysis
KW - Gene 11
KW - NSP6
KW - Phosphorylation
KW - Rotavirus
KW - Vaccine
N1 - Accession Number: 23161097; Mohan, K.V.K. 1 Glass, R.I. 2 Atreya, C.D. 1; Email Address: atreya@cber.fda.gov; Affiliation: 1: Section of Viral Pathogenesis and Vaccine Adverse Reactions, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; Source Info: Dec2006, Vol. 34 Issue 4, p265; Subject Term: ROTAVIRUS diseases; Subject Term: GREEN fluorescent protein; Subject Term: GENETIC polymorphisms; Subject Term: NUCLEIC acids -- Analysis; Author-Supplied Keyword: Gene 11; Author-Supplied Keyword: NSP6; Author-Supplied Keyword: Phosphorylation; Author-Supplied Keyword: Rotavirus; Author-Supplied Keyword: Vaccine; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.biologicals.2005.11.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeong, Hye-Sung
AU - Shin, Jin-Ho
AU - Choi, Jung-Yun
AU - Kim, Young-Lim
AU - Bae, Jei-Jun
AU - Kim, Byoung-Guk
AU - Ryu, Seung-Rel
AU - Kim, Soon-Nam
AU - Min, Hong-Ki
AU - Kim, Hong-Jin
AU - Park, Sue-Nie
T1 - Evaluation of viral clearance in the production of HPV-16 L1 virus-like particles purified from insect cell cultures
JO - Biologicals
JF - Biologicals
Y1 - 2006/12//
VL - 34
IS - 4
M3 - Article
SP - 273
EP - 279
SN - 10451056
AB - Abstract: Biopharmaceutical products produced from cell cultures have a potential for viral contamination from cell sources or from adventitious introduction during production. The objective of this study was to assess viral clearance in the production of insect cell-derived recombinant human papillomavirus (HPV)-16 type L1 virus-like particles (VLPs). We selected Japanese encephalitis virus (JEV), bovine viral diarrhea virus (BVDV), and minute virus of mice (MVM) as relevant viruses to achieve the aim of this study. A downstream process for the production of purified HPV-16 L1 VLPs consisted of detergent lysis of harvested cells, sonication, sucrose cushion centrifugation, and cesium chloride (CsCl) equilibrium density centrifugation. The capacity of each purification/treatment step to clear viruses was expressed as reduction factor by measuring the difference in log virus infectivity of sample pools before and after each process. As a result, detergent treatment (0.5% v/v, Nonidet P-40/phosphate-buffered saline) was effective for inactivating enveloped viruses such as JEV and BVDV, but no significant reduction (<1.0log10) was observed in the non-enveloped MVM. The CsCl equilibrium density centrifugation was fairly effective for separating all three relevant adventitious viruses with different CsCl buoyant density from that of HPV-16 L1 VLPs (JEV, BVDV, and MVM=4.30, 3.10, ≥4.40log10 reductions). Given the study conditions we used, overall cumulative reduction factors for clearance of JEV, BVDV, and MVM were ≥10.50, ≥9.20, and ≥6.40log10 in 150ml of starting cell cultures, respectively. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CULTURES (Biology)
KW - PAPILLOMAVIRUSES
KW - MICROORGANISMS
KW - MICROBIAL contamination
KW - BVDV
KW - HPV-16 L1 VLPs
KW - JEV
KW - MVM
KW - Viral clearance
N1 - Accession Number: 23161098; Jeong, Hye-Sung 1 Shin, Jin-Ho 2 Choi, Jung-Yun 2 Kim, Young-Lim 2 Bae, Jei-Jun 2 Kim, Byoung-Guk 2 Ryu, Seung-Rel 2 Kim, Soon-Nam 2 Min, Hong-Ki 2 Kim, Hong-Jin 1 Park, Sue-Nie 2; Email Address: suenie@kfda.go.kr; Affiliation: 1: College of Pharmacy, Chung-Ang University, #221 Huksuk-Dong, Dongjak-Ku, Seoul 156-756, Republic of Korea 2: Department of Biologics Evaluation, Korea Food and Drug Administration, #231 Jinheungno, Eunpyeong-Gu, Seoul 122-704, Republic of Korea; Source Info: Dec2006, Vol. 34 Issue 4, p273; Subject Term: CULTURES (Biology); Subject Term: PAPILLOMAVIRUSES; Subject Term: MICROORGANISMS; Subject Term: MICROBIAL contamination; Author-Supplied Keyword: BVDV; Author-Supplied Keyword: HPV-16 L1 VLPs; Author-Supplied Keyword: JEV; Author-Supplied Keyword: MVM; Author-Supplied Keyword: Viral clearance; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biologicals.2005.11.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zitella, Laura J.
AU - Friese, Christopher R.
AU - Hauser, Joanna
AU - Holmes Gobel, Barbara
AU - Woolery, Myra
AU - O'Leary, Colleen
AU - Andrews, Felicia A.
T1 - Putting Evidence Into Practice: Prevention of Infection.
JO - Clinical Journal of Oncology Nursing
JF - Clinical Journal of Oncology Nursing
Y1 - 2006/12//
VL - 10
IS - 6
M3 - Article
SP - 739
EP - 750
PB - Oncology Nursing Society
SN - 10921095
AB - The prevention of infection is an important outcome to measure in patients with cancer because infectious complications are a significant cause of morbidity and mortality. Nurses play a vital role in the prevention of infection in patients with cancer through nursing practice, research, and patient education. However, many common nursing interventions to prevent infection are based on tradition or expert opinion and have not been subjected to scientific examination. The 2005 Oncology Nursing Society Prevention of Infection Outcomes Intervention Project Team reviewed, critiqued, and summarized the research evidence for nursing interventions to prevent infections in patients with cancer. Pharmacologic and nonpharmacologic interventions were included because many advanced practice nurses prescribe medications. This article is an evidence-based review of nursing interventions to prevent infection in patients with cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Journal of Oncology Nursing is the property of Oncology Nursing Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER patients
KW - INFECTION
KW - PREVENTIVE medicine
KW - NURSE & patient
KW - ONCOLOGY nursing
N1 - Accession Number: 23294760; Zitella, Laura J. 1; Email Address: lzitella@yahoo.com Friese, Christopher R. 2 Hauser, Joanna 3 Holmes Gobel, Barbara 4 Woolery, Myra 5 O'Leary, Colleen 6 Andrews, Felicia A. 7,8; Affiliation: 1: Nurse practitioner, Division of Oncology, Stanford Hospital and Clinics, California 2: Research fellow, Dana-Farber Cancer Institute and Harvard School of Public Health Center for Outcomes and Policy Research, Boston, MA 3: Oncology nurse practitioner, San Francisco Oncology Associates, California 4: Oncology clinical nurse specialist, Northwestern Memorial Hospital, Chicago, IL 5: Pediatric clinical nurse specialist, National Institutes of Health, Bethesda, MD 6: Nurse staff educator, Medical Oncology, Northwestern Memorial Hospital 7: Officer, U.S. Public Health Service 8: Nurse manager, National Institutes of Health; Source Info: Dec2006, Vol. 10 Issue 6, p739; Subject Term: CANCER patients; Subject Term: INFECTION; Subject Term: PREVENTIVE medicine; Subject Term: NURSE & patient; Subject Term: ONCOLOGY nursing; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; Number of Pages: 12p; Document Type: Article
L3 - 10.1188/06.CJON.739-750
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DB - aph
ER -
TY - JOUR
AU - Bernard, Susan M.
AU - Anderson, Steven A.
T1 - Qualitative Assessment of Risk for Monkeypox Associated with Domestic Trade in Certain Animal Species, United States.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2006/12//
VL - 12
IS - 12
M3 - Article
SP - 1827
EP - 1833
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - In 2003, US officials identified several human monkeypox cases and traced the virus exposure to infected captive prairie dogs. The virus was likely introduced through a shipment of imported African rodents, which were kept with other mammals, including prairie dogs, in a pet distribution facility in the Midwest. To prevent the further introduction and spread of the virus, federal agencies restricted the importation of African rodents and restricted the domestic trade or movement of prairie dogs and certain other rodents. In this qualitative assessment of the risk for monkeypox associated with the 2003 outbreak, we conclude that the probability of further human infection is low; the risk is further mitigated by rodent import restrictions. Were this zoonotic disease to become established domestically, the public health effects could be substantial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Prairie dogs
KW - Viruses
KW - Zoonoses
KW - Monkeypox
KW - Human monkeypox
N1 - Accession Number: 23422851; Bernard, Susan M. 1; Email Address: susan.bernard@fda.hhs.gov; Anderson, Steven A. 1; Affiliations: 1: US Food and Drug Administration, College Park, Maryland, USA; Issue Info: Dec2006, Vol. 12 Issue 12, p1827; Thesaurus Term: Prairie dogs; Thesaurus Term: Viruses; Thesaurus Term: Zoonoses; Subject Term: Monkeypox; Subject Term: Human monkeypox; Number of Pages: 7p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Vallyathana, Val
T1 - Nanoparticles: Health Effects--Pros and Cons.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/12//
VL - 114
IS - 12
M3 - Article
SP - 1818
EP - 1825
PB - Superintendent of Documents
SN - 00916765
AB - With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of < 100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. Many fine particles generally considered "nuisance dusts" are likely to acquire unique surface properties when engineered to nanosize and may exhibit toxic biological effects. Consequently, the nuisance dust may be transported to distant sites and could induce adverse health effects. In addition the beneficial uses of NPs in drug delivery, cancer treatment, and gene therapy may cause unintentional human exposure. Because of our lack of knowledge about the health effects associated with NP exposure, we have an ethical duty to take precautionary measures regarding their use. In this review we highlight the possible toxic human health effects that can result from exposure to ultrafine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes. The comparability of engineered NPs to UFPs suggests that the human health effects are likely to be similar. Therefore, it is prudent to elucidate their toxicologic effect to minimize occupational and environmental exposure. Highlighting the human health outcomes caused by UFPs is not intended to give a lesser importance to either the unprecedented technologic and industrial rewards of the nanotechnology or their beneficial human uses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nanotechnology
KW - High technology
KW - Toxicology
KW - Poisons
KW - Environmental health
KW - Pollutants
KW - Nanoparticles
KW - Nanostructured materials
KW - Chemicals
KW - nanoparticle toxicity
KW - nanotechnology
KW - pros.
N1 - Accession Number: 23426224; Gwinn, Maureen R. 1; Vallyathana, Val 1; Email Address: vavl@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Dec2006, Vol. 114 Issue 12, p1818; Thesaurus Term: Nanotechnology; Thesaurus Term: High technology; Thesaurus Term: Toxicology; Thesaurus Term: Poisons; Thesaurus Term: Environmental health; Thesaurus Term: Pollutants; Subject Term: Nanoparticles; Subject Term: Nanostructured materials; Subject Term: Chemicals; Author-Supplied Keyword: nanoparticle toxicity; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: pros.; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 8p; Document Type: Article
L3 - 10.1289/ehp.8871
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DB - eih
ER -
TY - JOUR
AU - Herbert, Robin
AU - Moline, Jacqueline
AU - Skloot, Gwen
AU - Metzger, Kristina
AU - Baron, Sherry
AU - Luft, Benjamin
AU - Markowitz, Steven
AU - Udasin, Iris
AU - Harrison, Denise
AU - Stein, Diane
AU - Todd, Andrew
AU - Enright, Paul
AU - Stellman, Jeanne Mager
AU - Landrigan, Philip J.
AU - Levin, Stephen M.
T1 - The World Trade Center Disaster and the Health of Workers: Five-Year Assessment of a Unique Medical Screening Program.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/12//
VL - 114
IS - 12
M3 - Article
SP - 1853
EP - 1858
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Approximately 40,000 rescue and recovery workers were exposed to caustic dust and toxic pollutants following the 11 September 2001 attacks on the World Trade Center (WTC). These workers included traditional first responders, such as firefighters and police, and a diverse population of construction, utility, and public sector workers. METHODS: To characterize WTC-related health effects, the WTC Worker and Volunteer Medical Screening Program was established. This multicenter clinical program provides free standardized examinations to responders. Examinations include medical, mental health, and exposure assessment questionnaires; physical examinations; spirometry; and chest X rays. RESULTS: Of 9,442 responders examined between July 2002 and April 2004, 69% reported new or worsened respiratory symptoms while performing WTC work. Symptoms persisted to the time of examination in 59% of these workers. Among those who had been asymptomatic before September 11, 61% developed respiratory symptoms while performing WTC work. Twenty-eight percent had abnormal spirometry; forced vital capacity (FVC) was low in 21%; and obstruction was present in 5%. Among nonsmokers, 27% had abnormal spirometry compared with 13% in the general U.S. population. Prevalence of low FVC among nonsmokers was 5-fold greater than in the U.S. population (20% vs. 4%). Respiratory symptoms and spirometry abnormalities were significantly associated with early arrival at the site. CONCLUSION: WTC responders had exposure-related increases in respiratory symptoms and pulmonary function test abnormalities that persisted up to 2.5 years after the attacks. Long-term medical monitoring is required to track persistence of these abnormalities and identify late effects, including possible malignancies. Lessons learned should guide future responses to civil disasters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - World Trade Center Bombing, New York, N.Y., 1993
KW - Rescue work
KW - Emergency medical services
KW - September 11 Terrorist Attacks, 2001
KW - Terrorism -- New York (State)
KW - Medical screening
KW - Diagnostic services
KW - Medical care
KW - air pollution
KW - disaster response
KW - occupational lung disease
KW - pulmonary function
KW - September 11
KW - spirometry
KW - World Trade Center
N1 - Accession Number: 23426230; Herbert, Robin 1; Email Address: robin.herbert@mssm.edu; Moline, Jacqueline 1; Skloot, Gwen 2; Metzger, Kristina 1; Baron, Sherry 3; Luft, Benjamin 4; Markowitz, Steven 5; Udasin, Iris 6; Harrison, Denise 7; Stein, Diane 1; Todd, Andrew 1; Enright, Paul 8; Stellman, Jeanne Mager 1,9; Landrigan, Philip J. 1; Levin, Stephen M. 1; Affiliations: 1: Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA; 2: Division of Pulmonary, Critical Care & Sleep Medicine, Mount Sinai School of Medicine, New York, New York, USA; 3: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA; 4: Department of Medicine, State University of New York at Stony Brook, Port Jefferson, New York, USA; 5: Center for Biology of Natural Systems, Queens College, Flushing, New York, USA; 6: Environmental and Occupational Health Sciences Institute, University of Medicine & Dentistry of New Jersey, Piscataway, New Jersey, USA; 7: Department of Environmental Medicine, Bellevue Hospital Center/New York University School of Medicine, New York, New York, USA; 8: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 9: Mailman School of Public Health, Columbia University, New York, New York, USA; Issue Info: Dec2006, Vol. 114 Issue 12, p1853; Thesaurus Term: Health risk assessment; Subject Term: World Trade Center Bombing, New York, N.Y., 1993; Subject Term: Rescue work; Subject Term: Emergency medical services; Subject Term: September 11 Terrorist Attacks, 2001; Subject Term: Terrorism -- New York (State); Subject Term: Medical screening; Subject Term: Diagnostic services; Subject Term: Medical care; Author-Supplied Keyword: air pollution; Author-Supplied Keyword: disaster response; Author-Supplied Keyword: occupational lung disease; Author-Supplied Keyword: pulmonary function; Author-Supplied Keyword: September 11; Author-Supplied Keyword: spirometry; Author-Supplied Keyword: World Trade Center; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.9592
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23426230&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Strosnider, Heather
AU - Azziz-Baumgartner, Eduardo
AU - Banziger, Marianne
AU - Bhat, Ramesh V.
AU - Breiman, Robert
AU - Brune, Marie-Noel
AU - DeCock, Kevin
AU - Dilley, Abby
AU - Groopman, John
AU - Hell, Kerstin
AU - Henry, Sara H.
AU - Jeffers, Daniel
AU - Jolly, Curtis
AU - Jolly, Pauline
AU - Kibata, Gilbert N.
AU - Lewis, Lauren
AU - Xiumei Liu
AU - Luber, George
AU - McCoy, Leslie
AU - Mensah, Patience
T1 - Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/12//
VL - 114
IS - 12
M3 - Article
SP - 1898
EP - 1903
PB - Superintendent of Documents
SN - 00916765
AB - Consecutive outbreaks of acute aflatoxicosis in Kenya in 2004 and 2005 caused > 150 deaths. In response, the Centers for Disease Control and Prevention and the World Health Organization convened a workgroup of international experts and health officials in Geneva, Switzerland, in July 2005. After discussions concerning what is known about aflatoxins, the workgroup identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies. The workgroup also identified public health strategies that could be integrated with current agricultural approaches to resolve gaps in current knowledge and ultimately reduce morbidity and mortality associated with the consumption of aflatoxin-contaminated food in the developing world. Four issues that warrant immediate attention were identified: a) quantify the human health impacts and the burden of disease due to aflatoxin exposure; b) compile an inventory, evaluate the efficacy, and disseminate results of ongoing intervention strategies; c) develop and augment the disease surveillance, food monitoring, laboratory, and public health response capacity of affected regions; and d) develop a response protocol that can be used in the event of an outbreak of acute aflatoxicosis. This report expands on the workgroup's discussions concerning aflatoxin in developing countries and summarizes the findings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aflatoxins
KW - Mycotoxins
KW - Environmental health
KW - Public health
KW - Health risk assessment
KW - Food contamination
KW - Communicable diseases -- Transmission
KW - Kenya
KW - aflatoxins
KW - biomonitoring
KW - developing countries
KW - food safety
KW - hepatitis
KW - hepatocellular carcinoma
KW - public health
KW - surveillance
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 23426237; Strosnider, Heather 1; Email Address: hks9@cdc.gov; Azziz-Baumgartner, Eduardo 1; Banziger, Marianne 2; Bhat, Ramesh V. 3; Breiman, Robert 4; Brune, Marie-Noel 5; DeCock, Kevin 6; Dilley, Abby 7; Groopman, John 8; Hell, Kerstin 9; Henry, Sara H. 10; Jeffers, Daniel 11; Jolly, Curtis 12; Jolly, Pauline 13; Kibata, Gilbert N. 14; Lewis, Lauren 1; Xiumei Liu 15; Luber, George 1; McCoy, Leslie 1; Mensah, Patience 16; Affiliations: 1: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2: International Maize and Wheat Improvement Center, Nairobi, Kenya; 3: Centre for Science Society and Culture, Indian Council of Medical Research, Hyderabad, India; 4: Kenya Medical Research Institute, Centers for Disease Control and Prevention, Nairobi, Kenya; 5: World Health Organization, Geneva, Switzerland; 6: Centers for Disease Control and Prevention, Kenya Office, Nairobi, Kenya; 7: Resolve, Washington, DC, USA; 8: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; 9: Biological Control Center for Africa, International Institute of Tropical Agriculture, Cotonou, Benin; 10: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA; 11: International Maize and Wheat Improvement Center, Mexico City, Mexico; 12: Department of Agricultural Economics and Rural Sociology, Auburn University, Auburn, Alabama, USA; 13: School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA; 14: Kenya Agricultural Research Institute, Nairobi, Kenya; 15: Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China; 16: World Health Organization, Regional Office for Africa, Brazzaville, Republic of Congo; Issue Info: Dec2006, Vol. 114 Issue 12, p1898; Thesaurus Term: Aflatoxins; Thesaurus Term: Mycotoxins; Thesaurus Term: Environmental health; Thesaurus Term: Public health; Thesaurus Term: Health risk assessment; Thesaurus Term: Food contamination; Thesaurus Term: Communicable diseases -- Transmission; Subject: Kenya; Author-Supplied Keyword: aflatoxins; Author-Supplied Keyword: biomonitoring; Author-Supplied Keyword: developing countries; Author-Supplied Keyword: food safety; Author-Supplied Keyword: hepatitis; Author-Supplied Keyword: hepatocellular carcinoma; Author-Supplied Keyword: public health; Author-Supplied Keyword: surveillance ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
L3 - 10.1289/ehp.930
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23426237&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Barr, Dana B.
AU - Landsittel, Doug
AU - Nishioka, Marcia
AU - Thomas, Kent
AU - Curwin, Brian
AU - Raymer, James
AU - Donnelly, Kirby C.
AU - McCauley, Linda
AU - Ryan, P. Barry
T1 - Statistical Issues: Barr et al. Respond.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2006/12//
VL - 114
IS - 12
M3 - Letter
SP - A689
EP - A690
PB - Superintendent of Documents
SN - 00916765
AB - A letter to the editor is presented in response to the letter from David T. Mage and colleagues that comments on the article "A survey of laboratory and statistical issues related to farmworker exposure studies," by D. B. Barr and colleagues in a 2006 issue.
KW - HEALTH
KW - Letters to the editor
KW - Agricultural laborers
N1 - Accession Number: 23426199; Barr, Dana B. 1; Email Address: dbarr@cdc.gov; Landsittel, Doug 2; Nishioka, Marcia 3; Thomas, Kent 4; Curwin, Brian 5; Raymer, James 6; Donnelly, Kirby C. 7; McCauley, Linda 8; Ryan, P. Barry 9; Affiliations: 1: National Center for Environmental Health Centers for Disease Control and Prevention, Atlanta, Georgia; 2: Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, Pennsylvania; 3: Battelle Memorial Institute Columbus, Ohio; 4: National Exposure Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park, North Carolina; 5: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Cincinnati, Ohio; 6: RTI International Research Triangle Park, North Carolina; 7: Texas A&M University System, Health Science Center College Station, Texas; 8: School of Human Environmental Sciences, University of Pennsylvania, Philadelphia, Pennsylvania; 9: Rollins School of Public Health Emory University, Atlanta, Georgia; Issue Info: Dec2006, Vol. 114 Issue 12, pA689; Thesaurus Term: HEALTH; Subject Term: Letters to the editor; Subject Term: Agricultural laborers; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hwi-yeol Yun
AU - Min Sun Baek
AU - In Sook Park
AU - Bo Kyung Choi
AU - Kwang-il Kwon
T1 - Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers.
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
Y1 - 2006/12//
VL - 62
IS - 12
M3 - Article
SP - 1033
EP - 1039
SN - 00316970
AB - The objectives of this retrospective study were to examine the relationship between the bioavailability of itraconazole and the type of food consumed and to determine the effects of food consumption on the pharmacokinetic parameters following a single oral dose of itraconazole in healthy volunteers. The plasma itraconazole concentration-time data were pooled from four pharmacokinetic studies in 144 healthy subjects. Individual pharmacokinetic values were estimated as model-independent (AUC, C max, and T max) and model-dependent ( T lag, K a, K cp, K pc, K el, and V d/ F; two-compartment open model with lag time) parameters using the WinNonlin software program. We estimated the population characteristics of the food effects using NONMEM. The consumption of a bread meal before the administration of itraconazole caused a significant increase in its bioavailability, as well as increases in the peak plasma concentration and lag time for itraconazole absorption. On the contrary, consumption of a rice meal before the administration of itraconazole caused a significant decrease in its bioavailability. Therefore, although a dose of itraconazole is normally administered immediately after a meal to increase its bioavailability, this is not an effective strategy after a rice meal. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Clinical Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD consumption
KW - RICE
KW - BREAD
KW - BIOAVAILABILITY
KW - PHARMACOKINETICS
KW - COMPUTER software
KW - Bioavailability
KW - Bioavailability. Itraconazole
KW - Food consumption
KW - Itraconazole
KW - Pharmacokinetic parameters
KW - Rice and bread meals
N1 - Accession Number: 23127581; Hwi-yeol Yun 1 Min Sun Baek 2 In Sook Park 2 Bo Kyung Choi 2 Kwang-il Kwon 1; Email Address: kwon@cnu.ac.kr; Affiliation: 1: College of Pharmacy , Chungnam National University , Daejeon 305-764 South Korea 2: Bioequivalence Division , Drug Evaluation Department, Korea Food and Drug Administration , Seoul South Korea; Source Info: Dec2006, Vol. 62 Issue 12, p1033; Subject Term: FOOD consumption; Subject Term: RICE; Subject Term: BREAD; Subject Term: BIOAVAILABILITY; Subject Term: PHARMACOKINETICS; Subject Term: COMPUTER software; Author-Supplied Keyword: Bioavailability; Author-Supplied Keyword: Bioavailability. Itraconazole; Author-Supplied Keyword: Food consumption; Author-Supplied Keyword: Itraconazole; Author-Supplied Keyword: Pharmacokinetic parameters; Author-Supplied Keyword: Rice and bread meals; NAICS/Industry Codes: 311814 Commercial bakeries and frozen bakery product manufacturing; NAICS/Industry Codes: 311824 Dry Pasta, Dough, and Flour Mixes Manufacturing from Purchased Flour; NAICS/Industry Codes: 311812 Commercial Bakeries; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 111160 Rice Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 7p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00228-006-0200-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Chang Hee
AU - Cho, Yang Hee
AU - Park, Kwan Hwa
T1 - Assessment of estimated daily intake of nitrite by average consumption of processed foods in Korea
JO - Food Control
JF - Food Control
Y1 - 2006/12//
VL - 17
IS - 12
M3 - Article
SP - 950
EP - 956
SN - 09567135
AB - Abstract: This study has been performed to estimate the average daily intake of nitrite used in Korea as a color fixative. The crude estimation of daily intake was calculated based on maximum permitted levels (MPL) and national food disappearance data in 1998. In order to refine estimated daily intake (EDI), daily food consumption nationwide National Health and Nutrition Survey in 1998 and the concentration of nitrite in their permitted foods were applied. The crude EDI of nitrite was 17.85μg/kgbw/day, representing 25.5% of acceptable daily intake (ADI) assigned by JECFA. The refined average EDI for nitrite was 0.87μg/kg bw/day, representing 1.25% of ADI. For average consumers of age–sex groups ranged from 0.2 to 4.8μg/kgbw/day, representing 0.3%–6.9% of the ADI. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD industry
KW - COST & standard of living
KW - FOOD consumption
KW - FOOD supply
KW - Acceptable daily intake (ADI)
KW - Estimated daily intake (EDI)
KW - Nitrite
N1 - Accession Number: 21338491; Lee, Chang Hee 1; Email Address: chlee65@kfda.go.kr Cho, Yang Hee 2 Park, Kwan Hwa 3; Affiliation: 1: Busan Regional Food and Drug Administration, Busan 608-829, Republic of Korea 2: Korea Health Industry Development Institute, Seoul 156-050, Republic of Korea 3: Seoul National University, Seoul 144-744, Republic of Korea; Source Info: Dec2006, Vol. 17 Issue 12, p950; Subject Term: FOOD industry; Subject Term: COST & standard of living; Subject Term: FOOD consumption; Subject Term: FOOD supply; Author-Supplied Keyword: Acceptable daily intake (ADI); Author-Supplied Keyword: Estimated daily intake (EDI); Author-Supplied Keyword: Nitrite; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.foodcont.2005.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andreishcheva, Ekaterina N.
AU - Vann, Willie F.
T1 - Escherichia coli BL21(DE3) chromosome contains a group II capsular gene cluster
JO - Gene
JF - Gene
Y1 - 2006/12//
VL - 384
M3 - Article
SP - 113
EP - 119
SN - 03781119
AB - Abstract: During our study of de novo synthesis of Escherichia coli K1 capsular polysaccharides, we found that E. coli BL21(DE3) has a capsular gene cluster, similar to those of group II capsular E. coli strains. Analysis of the nucleotide sequence of the E. coli BL21(DE3) gene cluster showed homologues to all group II regions 1 and 3 genes and the presence of an IS1 element in one of the region 2 ORFs, which likely prevents capsule expression. Complementation analysis showed that region 1 and 3 genes encode functional proteins that are sufficient for the export of newly synthesized polysaccharide. The gene products of Bl21(DE3) kpsC and kpsS supported in vitro de novo synthesis of K1 polysaccharide when co-expressed with K1 NeuE and NeuS. Sequence homology between BL21(DE3) region 2 open reading frames and capsule-related genes in other bacteria such as Haemophilus influenzae serotype b, suggests that the encapsulated ancestor of BL21(DE3) may have produced a ribose/ribitol-phosphate containing polysaccharide. [Copyright &y& Elsevier]
AB - Copyright of Gene is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance
KW - ESCHERICHIA coli
KW - ENTEROBACTERIACEAE
KW - DNA polymerases
KW - Capsule gene cluster
KW - Cetyltrimethylammonium bromide ( CTAB )
KW - Cytidine-5'-monophospho-N-acetylneuraminic acid ( CMP-NeuNAc )
KW - Diethylpyrocarbonate ( DEPC )
KW - E. coli B
KW - Microliter ( μl )
KW - N-acetylneuraminic or sialic acid ( NeuNAc )
KW - Nuclear magnetic resonance ( NMR )
KW - Polymerase chain reaction. ( PCR )
KW - Polysaccharide
N1 - Accession Number: 23211974; Andreishcheva, Ekaterina N. 1 Vann, Willie F.; Email Address: wvann@helix.nih.gov; Affiliation: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Building 29, Room 103, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Dec2006, Vol. 384, p113; Subject Term: NUCLEAR magnetic resonance; Subject Term: ESCHERICHIA coli; Subject Term: ENTEROBACTERIACEAE; Subject Term: DNA polymerases; Author-Supplied Keyword: Capsule gene cluster; Author-Supplied Keyword: Cetyltrimethylammonium bromide ( CTAB ); Author-Supplied Keyword: Cytidine-5'-monophospho-N-acetylneuraminic acid ( CMP-NeuNAc ); Author-Supplied Keyword: Diethylpyrocarbonate ( DEPC ); Author-Supplied Keyword: E. coli B; Author-Supplied Keyword: Microliter ( μl ); Author-Supplied Keyword: N-acetylneuraminic or sialic acid ( NeuNAc ); Author-Supplied Keyword: Nuclear magnetic resonance ( NMR ); Author-Supplied Keyword: Polymerase chain reaction. ( PCR ); Author-Supplied Keyword: Polysaccharide; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.gene.2006.07.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Steven
AU - Ezzati-Rice, Trena
AU - Yu, William
T1 - The impact of survey attrition on health insurance coverage estimates in a National Longitudinal Health Care Survey.
JO - Health Services & Outcomes Research Methodology
JF - Health Services & Outcomes Research Methodology
Y1 - 2006/12//
VL - 6
IS - 3/4
M3 - Article
SP - 111
EP - 125
SN - 13873741
AB - Timely, accurate and reliable estimates of the population’s health insurance status are essential inputs to policymakers to inform assessments of the population’s access to medical care and analyses of associated health care expenditures. Alternative criteria that have been used to produce annual estimates of the uninsured include the following specifications: those uninsured for a full-year, those ever uninsured during a year, and those uninsured at a specific point in time. The Medical Expenditure Panel Survey (MEPS), one of the core health care surveys in the United States, supports all three types of estimates. In this paper, a summary is provided of the survey operations, informational materials, the interviewer training and experience of the field force, and the refusal conversion techniques employed in the MEPS to maintain respondent cooperation for five rounds of interviewing, to help minimize sample attrition. The impact of nonresponse attributable to survey attrition is also assessed with respect to the national health insurance coverage estimates derived from the MEPS. The study includes an examination of the quality of the nonresponse adjustments employed to adjust for potential nonresponse bias attributable to survey attrition. The overlapping panel design of the MEPS survey is particularly well suited to inform these studies. The presentation concludes with a discussion of strategies under consideration that may yield additional improvements in the accuracy for these critical policy relevant survey estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services & Outcomes Research Methodology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - MEDICAL care -- Finance
KW - HEALTH surveys -- United States
KW - ATTRITION in research studies
KW - UNITED States
KW - Attrition
KW - Health insurance
KW - MEPS
KW - Nonresponse
N1 - Accession Number: 51657375; Cohen, Steven 1; Email Address: scohen@ahrq.gov; Ezzati-Rice, Trena; Email Address: tezzatir@ahrq.gov; Yu, William; Email Address: wyu@ahrq.gov; Affiliations: 1: Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality , 540 Gaither Road, John M. Eisenberg Building Rockville 20850 USA; Issue Info: Dec2006, Vol. 6 Issue 3/4, p111; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICAL care -- Finance; Subject Term: HEALTH surveys -- United States; Subject Term: ATTRITION in research studies; Subject: UNITED States; Author-Supplied Keyword: Attrition; Author-Supplied Keyword: Health insurance; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: Nonresponse; Number of Pages: 15p; Document Type: Article
L3 - 10.1007/s10742-006-0006-z
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Götz, Hannelore M.
AU - van Bergen, Jan E. A. M.
AU - Veldhuijzen, Irene K.
AU - Hoebe, Christian J. P. A.
AU - Broer, Jan
AU - Coenen, A. J. J.
AU - de Groot, F.
AU - Verhooren, M. J. C.
AU - van Schaik, D. T.
AU - Richardus, Jan H.
T1 - Lessons learned from a population-based chlamydia screening pilot.
JO - International Journal of STD & AIDS
JF - International Journal of STD & AIDS
Y1 - 2006/12//
VL - 17
IS - 12
M3 - Article
SP - 826
EP - 830
PB - Sage Publications, Ltd.
SN - 09564624
AB - We evaluated process organization and response optimization in a home-based Chlamydia trachomatis (Ct) screening project in the Netherlands among 15- to 29-year-old women and men. The method used was computer-supported data flow, from population sampling to informing participants of the result. A new test kit or a letter reminded non-respondents after six weeks. Fifteen-year olds required parental consent. Urine arrived at the laboratory within 29 days from invitation, and four (1–11) days after collection, indicating good specimen quality. Test kits had a higher response than letters (15 versus 10%). Response in 15-year olds was 33%; with 2% Ct infected sexually active 15 year olds. In Conclusion, purpose made computer software is essential for an efficient screening programme. Sending urine by mail does not impair diagnostics. Reminders are necessary and effective after four weeks. Necessary parental consent for under 16-year olds should not be a deterrent to offer Ct screening to this age group. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of STD & AIDS is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlamydia trachomatis
KW - Clinical epidemiology
KW - Chlamydia infections
KW - Urinalysis
KW - Patient monitoring equipment
KW - Diagnostic reagents & test kits
KW - Netherlands
KW - ADOLESCENT
KW - chlamydia infections/epidemiology/prevention and control/urine
KW - CHLAMYDIA TRACHOMATIS
KW - COMPUTER SUPPORT
KW - female
KW - human
KW - MALE
KW - MASS SCREENING/ORGANIZATION AND ADMINISTRATION
KW - municipal health services
KW - outcome assessment
KW - programme evaluation
KW - THE NETHERLANDS
N1 - Accession Number: 23561598; Götz, Hannelore M. 1; Email Address: gotzh@ggd.rotterdam.nl; van Bergen, Jan E. A. M. 2; Veldhuijzen, Irene K. 1; Hoebe, Christian J. P. A. 3; Broer, Jan 4; Coenen, A. J. J. 2; de Groot, F. 3; Verhooren, M. J. C. 5; van Schaik, D. T. 2; Richardus, Jan H. 1,6; Affiliations: 1: Department of Infectious Diseases, Municipal Public Health Service, Rotterdam (The National Institute for STD and AIDS Control in the Netherlands), The Netherlands; 2: STI AIDS Netherlands, The Netherlands; 3: Municipal Health Service Eastern South Limburg, Heerlen, The Netherlands; 4: Municipal Health Service Groningen, Netherlands; 5: Municipal Health Service 'Hart voor Brabant', Tilburg, Netherlands; 6: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Issue Info: Dec2006, Vol. 17 Issue 12, p826; Thesaurus Term: Chlamydia trachomatis; Thesaurus Term: Clinical epidemiology; Subject Term: Chlamydia infections; Subject Term: Urinalysis; Subject Term: Patient monitoring equipment; Subject Term: Diagnostic reagents & test kits; Subject: Netherlands; Author-Supplied Keyword: ADOLESCENT; Author-Supplied Keyword: chlamydia infections/epidemiology/prevention and control/urine; Author-Supplied Keyword: CHLAMYDIA TRACHOMATIS; Author-Supplied Keyword: COMPUTER SUPPORT; Author-Supplied Keyword: female; Author-Supplied Keyword: human; Author-Supplied Keyword: MALE; Author-Supplied Keyword: MASS SCREENING/ORGANIZATION AND ADMINISTRATION; Author-Supplied Keyword: municipal health services; Author-Supplied Keyword: outcome assessment; Author-Supplied Keyword: programme evaluation; Author-Supplied Keyword: THE NETHERLANDS; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1258/095646206779307577
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23561598&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106157049
T1 - Lessons learned from a population-based chlamydia screening pilot.
AU - Götz HM
AU - van Bergen JEA
AU - Veldhuijzen IK
AU - Hoebe CJP
AU - Broer J
AU - Coenen AJJ
AU - Groot F
AU - Verhooren MJC
AU - van Schaik DT
AU - Richardus JH
Y1 - 2006/12//
N1 - Accession Number: 106157049. Language: English. Entry Date: 20070921. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Zorg Onderzoek Nederland. NLM UID: 9007917.
KW - Chlamydia Infections -- Diagnosis
KW - Chlamydia Infections -- Epidemiology
KW - Chlamydia Trachomatis
KW - Adolescence
KW - Adult
KW - Chi Square Test
KW - Chlamydia Infections -- Psychosocial Factors
KW - Chlamydia Infections -- Urine
KW - Confidence Intervals
KW - Data Analysis Software
KW - Female
KW - Funding Source
KW - Health Screening -- Methods
KW - Health Screening -- Utilization
KW - T-Tests
KW - Human
SP - 826
EP - 830
JO - International Journal of STD & AIDS
JF - International Journal of STD & AIDS
JA - INT J STD AIDS
VL - 17
IS - 12
PB - Sage Publications, Ltd.
AB - We evaluated process organization and response optimization in a home-based Chlamydia trachomatis (Ct) screening project in the Netherlands among 15- to 29-year-old women and men. The method used was computer-supported data flow, from population sampling to informing participants of the result. A new test kit or a letter reminded non-respondents after six weeks. Fifteen-year olds required parental consent. Urine arrived at the laboratory within 29 days from invitation, and four (1-11) days after collection, indicating good specimen quality. Test kits had a higher response than letters (15 versus 10%). Response in 15-year olds was 33%; with 2% Ct infected sexually active 15 year olds. In Conclusion, purpose made computer software is essential for an efficient screening programme. Sending urine by mail does not impair diagnostics. Reminders are necessary and effective after four weeks. Necessary parental consent for under 16-year olds should not be a deterrent to offer Ct screening to this age group.
SN - 0956-4624
AD - Department of Infectious Diseases, Municipal Public Health Service, Rotterdam (The National Institute for STD and AIDS Control in the Netherlands)
U2 - PMID: 17212860.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kissin, Wendy
AU - McLeod, Caroline
AU - Sonnefeld, Joseph
AU - Stanton, Arlene
T1 - Experiences of a National Sample of Qualified Addiction Specialists Who Have and Have Not Prescribed Buprenorphine for Opioid Dependence.
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
Y1 - 2006/12//
VL - 25
IS - 4
M3 - Article
SP - 91
EP - 103
SN - 10550887
AB - The limited availability of medication-assisted treatment has created a treatment gap leaving many opioid dependent individuals without access to appropriate treatment. Survey data from a national random sample of 545 addictions physicians with waivers to provide buprenorphine treatment under The Drug Addiction Treatment Act of 2000 are presented. During the first year, an estimated 63,204 opioid dependent patients were treated with buprenorphine; many were dependent on prescription opioids and were new to drug treatment. Prescribing physicians reported high treatment effectiveness and patient satisfaction, with minimal adverse reactions or evidence of diversion. However, many waivered physicians had not provided buprenorphine treatment. Prescribers identified challenges such as induction logistics, recordkeeping requirements, the 30-patient limit, DEA involvement, and limited patient compliance. Buprenorphine treatment could potentially reduce the treatment gap by providing safe and effective treatment for opioid dependence and by attracting patients who do not typically seek care at opioid treatment programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Addictive Diseases is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OPIOID abuse
KW - BUPRENORPHINE
KW - DRUG abuse
KW - DRUG utilization
KW - PRESCRIPTION of drugs
KW - PHYSICIANS
KW - PATIENT satisfaction
KW - SUBSTANCE abuse -- Treatment
KW - PATIENT compliance
KW - Buprenorphine
KW - DATA 2000
KW - medication-assisted treatment
KW - opioid dependence
N1 - Accession Number: 23584098; Kissin, Wendy 1; Email Address: wendykissin@westat.com McLeod, Caroline 1 Sonnefeld, Joseph 1 Stanton, Arlene 2; Affiliation: 1: Westate, 1700 Research Boulevard, Rockville, MD 20850 2: Division of Pharmacologic Therapies, Center for Substance Abuse Treatment (CSAT), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD; Source Info: 2006, Vol. 25 Issue 4, p91; Subject Term: OPIOID abuse; Subject Term: BUPRENORPHINE; Subject Term: DRUG abuse; Subject Term: DRUG utilization; Subject Term: PRESCRIPTION of drugs; Subject Term: PHYSICIANS; Subject Term: PATIENT satisfaction; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: PATIENT compliance; Author-Supplied Keyword: Buprenorphine; Author-Supplied Keyword: DATA 2000; Author-Supplied Keyword: medication-assisted treatment; Author-Supplied Keyword: opioid dependence; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1300/J069v25n04-09
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fei Chen
AU - Yongju Lu
AU - Castranova, Vince
AU - Zhiwei Li
AU - Karin, Michael
T1 - Loss of Ikkβ Promotes Migration and Proliferation of Mouse Embryo Fibroblast Cells*.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/12//12/1/2006
VL - 281
IS - 48
M3 - Article
SP - 37142
EP - 37149
SN - 00219258
AB - The IβB kinase complex (IKK) is central to the activation of NF-βB, a critical transcription factor governing expression of genes involved in cell proliferation and anti-apoptotic responses. Mice with genetic disruptions of the Ikkβ or Ikkγ gene loci die during embryogenesis because of severe hepatic apoptosis. We now show that Ikkβ-/- gene deficiency promotes migration and proliferation of mouse embryo fibroblast cells. Morphological analyses revealed an unusual protrusion of the cytoplasm in Ikkβ-/- cells when cultured at a lower density. In a Boyden chamber assay, Ikkβ-/- cells exhibited a high rate of invasion and migration. Enhanced formation of actin stress fibers was also observed in the Ikkβ-/- cells. Mechanistic studies indicated that IKKβ affects the expression of proteins involved in the assembly of cytoskeleton and cell movement. Furthermore, re-expression of Ikkβ and antioxidant treatment in Ikkβ-/- cells caused a reversal of protrusive phenotype and high motility, respectively. Furthermore, elimination of reactive oxygen species (ROS) blocked expression of snail and subsequently derepressed E-cadherin expression. Although the underlying mechanism is likely entangled and complicated, the data presented indicate that generation of ROS played a key role in the morphological and mobility changes in Ikkβ-/- cells. These data thus suggest that IKKβ provides inhibitory signals for cell mobility and growth. Deficiency in the Ikkβ gene promotes cell mobilization, at least partially, through a ROS-dependent mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - TRANSCRIPTION factors
KW - GENE expression
KW - APOPTOSIS
KW - CYTOPLASM
KW - PROTOPLASM
N1 - Accession Number: 23576162; Fei Chen 1; Email Address: Ifd3@cdc.gov Yongju Lu 1 Castranova, Vince 1 Zhiwei Li 2 Karin, Michael 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093; Source Info: 12/1/2006, Vol. 281 Issue 48, p37142; Subject Term: FIBROBLASTS; Subject Term: TRANSCRIPTION factors; Subject Term: GENE expression; Subject Term: APOPTOSIS; Subject Term: CYTOPLASM; Subject Term: PROTOPLASM; Number of Pages: 8p; Illustrations: 4 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M603631200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23576162&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
AU - Wu, John Z.
AU - Schopper, Aaron W.
T1 - Frequency weighting derived from power absorption of fingers–hand–arm system under z h-axis vibration
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2006/12//
VL - 39
IS - 12
M3 - Article
SP - 2311
EP - 2324
SN - 00219290
AB - Abstract: The objectives of this study are to derive the frequency weighting from three vibration power absorption (VPA) methods (finger VPA, palm VPA, and total or hand VPA), and to explore whether these energy methods are better than the currently accepted acceleration method. To calculate the VPA weightings, the mechanical impedance of eight subjects exposed to a broadband random vibration spectrum in the z h-axis using 18 combinations of hand couplings and applied forces was measured. The VPA weightings were compared with the frequency weighting specified in ISO 5349-1 [2001. Mechanical Vibration—Measurement and Evaluation of Human Exposure to Hand-Transmitted Vibration—Part 1: General Requirements. International Organization for Standardization, Geneva, Switzerland]. This study found that the hand and palm VPA weightings are very similar to the ISO weighting but the finger VPA weighting for the combined grip and push action is much higher than the ISO weighting at frequencies higher than 25Hz. Therefore, this study predicted that the total power absorption of the entire hand–arm system is likely to be correlated with psychophysical response or subjective sensation. However, if the ISO weighting method cannot yield good predictions of the vibration-induced disorders in the fingers and hand, the hand and palm energy methods are unlikely to yield significantly better predictions. The finger VPA is a vibration measure between unweighted and ISO weighted accelerations. The palm VPA method may have some value for studying the disorders in the wrist–arm system. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - JOINTS (Anatomy)
KW - GRIP strength
KW - PALM (Anatomy)
KW - BIOMECHANICS
KW - Energy absorption
KW - Frequency weighting
KW - Hand–arm vibration
KW - Hand-transmitted vibration
KW - Vibration-induced white finger
N1 - Accession Number: 22016360; Dong, Ren G.; Email Address: rkd6@cdc.gov Welcome, Daniel E. 1 McDowell, Thomas W. 1 Wu, John Z. 1 Schopper, Aaron W. 1; Affiliation: 1: Engineering & Control Technology Branch, HELD, National Institute for Occupational Safety and Health, CDC, MS L-2027, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Dec2006, Vol. 39 Issue 12, p2311; Subject Term: JOINTS (Anatomy); Subject Term: GRIP strength; Subject Term: PALM (Anatomy); Subject Term: BIOMECHANICS; Author-Supplied Keyword: Energy absorption; Author-Supplied Keyword: Frequency weighting; Author-Supplied Keyword: Hand–arm vibration; Author-Supplied Keyword: Hand-transmitted vibration; Author-Supplied Keyword: Vibration-induced white finger; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jbiomech.2005.07.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hill, L. L.
AU - Foote, J. C.
AU - Erickson, B. D.
AU - Cerniglia, C. E.
AU - Denny, G. S.
T1 - Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2006/12//
VL - 31
IS - 6
M3 - Article
SP - 599
EP - 604
PB - Wiley-Blackwell
SN - 02694727
AB - Background and objective: The objective of this research was to determine the effects of the dietary supplement Echinacea purpurea on aerobic and anaerobic bacteria common to the human gastrointestinal (GI) tract. Botanical extracts have shown in vitro antimicrobial effects against certain pathogenic bacteria. It is uncertain if medicinal herbs have any effect against pathogenic bacteria or on the native GI microbiota. Methods: Fifteen human subjects consumed 1000 mg of standardized E. purpurea for 10 days. Faecal samples were collected at baseline, 10 days and 17–18 days following supplementation. Samples were tested for select aerobic and anaerobic bacteria using plate culture microbiological methods. Results and discussion: Significant increases were found for total aerobic bacteria, Bacteroides group and Bacteroides fragilis after E. purpurea exposure. Supplementation did not significantly alter the number of enteric bacteria, enterococci, lactobacilli, bifidobacteria or total anaerobic bacteria. Conclusion: Echinacea supplementation has altered the GI microbiota. The health consequences associated with this change are unknown but previous research has shown increased Bacteroides concentrations associated with diarrhoea, inflammatory bowel disease and increased risk of colon cancer. Additional research should delineate the role of Echinacea in the stimulation of Bacteroides and describe the effects of other botanical supplements to the GI microbiota. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BOTANICAL research
KW - ECHINACEA (Plants)
KW - GASTROINTESTINAL system
KW - PATHOGENIC bacteria
KW - ANAEROBIC bacteria
KW - AEROBIC bacteria
KW - BACTEROIDES
KW - THERAPEUTIC use
KW - botanical supplement
KW - dietary supplement
KW - Echinacea purpurea
KW - gastrointestinal microbiota
KW - herbal supplement
KW - human
N1 - Accession Number: 23216952; Hill, L. L. 1; Email Address: llhill@uark.edu Foote, J. C. 2 Erickson, B. D. 3 Cerniglia, C. E. 3 Denny, G. S. 4; Affiliation: 1: Food Science and Human Environmental Sciences, University of Arkansas, Fayetteville, AR 2: Human Nutrition, Department of Human Environmental Sciences, University of Arkansas, Fayetteville, AR 3: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 4: Educational Foundations, College of Education and Health Professions, University of Arkansas, Fayetteville, AR, USA; Source Info: Dec2006, Vol. 31 Issue 6, p599; Subject Term: BOTANICAL research; Subject Term: ECHINACEA (Plants); Subject Term: GASTROINTESTINAL system; Subject Term: PATHOGENIC bacteria; Subject Term: ANAEROBIC bacteria; Subject Term: AEROBIC bacteria; Subject Term: BACTEROIDES; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: botanical supplement; Author-Supplied Keyword: dietary supplement; Author-Supplied Keyword: Echinacea purpurea; Author-Supplied Keyword: gastrointestinal microbiota; Author-Supplied Keyword: herbal supplement; Author-Supplied Keyword: human; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1365-2710.2006.00781.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23216952&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bányai, K.
AU - Jiang, B.
AU - Bogdán, Á.
AU - Horváth, B.
AU - Jakab, F.
AU - Meleg, E.
AU - Martella, V.
AU - Magyari, L.
AU - Melegh, B.
AU - Szűcs, G.
T1 - Prevalence and molecular characterization of human group C rotaviruses in Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2006/12//
VL - 37
IS - 4
M3 - Article
SP - 317
EP - 322
SN - 13866532
AB - Abstract: Background: Group C rotaviruses are recognized enteric pathogens of humans and animals. Human group C rotaviruses have been associated with sporadic episodes and large outbreaks of gastroenteritis in children and adults but their epidemiology and ecology are still unexplored. Objectives: To collect epidemiological data on group C rotavirus infections among children with gastroenteritis in Hungary and perform molecular characterization on the identified strains. Study design: Fecal samples were collected during the 2003 surveillance in Baranya County, Hungary. The presence of group C rotavirus RNA was investigated by polyacrylamide gel electrophoresis and by reverse transcription-nested polymerase chain reaction for the VP6 gene. The identified strains were further characterized by sequencing and phylogenetic analysis of the VP7, VP6, VP4, and NSP4 genes. Results: Three of 472 samples (0.6%) tested positive for group C rotavirus. Two samples were selected for molecular analysis. Strains BaC 6104/03 and BaC 11549/03 displayed an overall identity of >99.8% and 99.3% at the nucleotide and amino acid level, respectively. The VP7 of the strain BaC 6104/03 was most closely related (99.5% aa) to the Nigerian strain Jajeri, while the VP4s of strains BaC 6104/03 and BaC 11549/03 were more similar (98.1% aa) to strains Belem and 208, detected in Brazil and China, respectively. Conclusions: Based on this 1-year study, we conclude that group C rotaviruses are not of epidemiological relevance in the etiology of childhood acute gastroenteritis in Hungary. The low sequence divergence between the Hungarian strains suggested that a single group C rotavirus strain circulated in this period in the study area. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases
KW - ROTAVIRUSES
KW - EPIDEMIOLOGY
KW - RNA
KW - GENES
KW - JUVENILE diseases
KW - Diarrhea
KW - Epidemiology
KW - Laboratory diagnostics
KW - Phylogenetic analysis
KW - RNA profile
N1 - Accession Number: 22966013; Bányai, K. 1,2; Email Address: bkrota@hotmail.com Jiang, B. 3 Bogdán, Á. 1 Horváth, B. 1 Jakab, F. 1 Meleg, E. 1,2 Martella, V. 4 Magyari, L. 5 Melegh, B. 5 Szűcs, G. 1,2; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7., H-7623 Pécs, Hungary 2: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary 3: Respiratory and Gastroenteritis Viruses Branch, Division of Viral Diseases, MSG04, Centers for Disease Control and Prevention, Atlanta, 1600 Clifton Road, GA 30333, USA 4: Department of Animal Health and Well-Being, University of Bari, Sp Casamassima Km 3, 70010 Valenzano, Bari, Italy 5: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary; Source Info: Dec2006, Vol. 37 Issue 4, p317; Subject Term: ROTAVIRUS diseases; Subject Term: ROTAVIRUSES; Subject Term: EPIDEMIOLOGY; Subject Term: RNA; Subject Term: GENES; Subject Term: JUVENILE diseases; Author-Supplied Keyword: Diarrhea; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Laboratory diagnostics; Author-Supplied Keyword: Phylogenetic analysis; Author-Supplied Keyword: RNA profile; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jcv.2006.08.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22966013&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yun-Sook Kang
AU - Yong-Sun Do
AU - Sun-Kyung Yoon
AU - Myeong-Ae Yu
AU - Chang-Min Kim
AU - Jong-Ok Lee
AU - Yu-Ryang Pyuni
T1 - Prevalence and Antimicrobial Resistance of Campylobacter jejuni and Campylobacter coli Isolated from Raw Chicken Meat and Human Stools in Korea.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2006/12//
VL - 69
IS - 12
M3 - Article
SP - 2915
EP - 2923
SN - 0362028X
AB - Prevalence of Campylobacter in raw chicken meat and human stools and subsequent antibiotic resistance profiles of the pathogenic isolates obtained from 2000 through 2002 were investigated. Campylobacter jejuni and Campylobacter coli were isolated from 570 of the 923 raw chicken meat samples collected from traditional markets, large retail stores, or department stores in Korea, resulting in the isolation rate of 61.8%. A total of 579 Campylobacrer isolates were obtained from raw chicken (36.3% for C. jejuni and 26.4% for C. coil) with the average population of 335.6 CFU/g. From 513 human stool samples, 15 isolates of Campylobacrer were detected. Seasonal variation in the quantification of C. co/i was not noticeable throughout the year, while the isolation rate of C. jejuni was the highest in September through October (840 CFU/g) followed by that of July through August and May through June in decreasing order, showing a significant seasonal effect (P < 0.05). Contamination of Campylobacrer was more severe in raw chicken meat sold in traditional markets than in those sold in large retail stores and department stores. Prevalence of Campylobacrer in raw chicken sold in traditional markets was significantly influenced by seasonal changes (P < 0.05), whereas the samples obtained from other places was less affected by the seasonal changes. Susceptibilities of the 594 chicken isolates to ciprofloxaxin, chloramphenicol, erythromycin, kanamycin, nalidixic acid, and tetracycline were determined by an E-test. Campylobacter isolates were the most resistant to nalidixic acid (91.4%) followed by ciprofloxaxin (87.9%), tetracycline (87.2%), kanamycin (30.6%), erythromycin (19.4%), and chloramphenicol (1.3%). Human isolates showed a similar resistance to the six antibiotics tested. The proportion of Campylobacter isolates with multidrug resistance to four or more antimicrobials obtained from 2000 through 2002 ranged from 28 to 43.5%, indicating that it could be a serious health-threatening factor. This study suggests that it is prudent to establish an effective National Monitoring Program in Korea for the prevention and control of Campylobacrer spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Campylobacter
KW - Campylobacter jejuni
KW - Contamination (Technology)
KW - Poultry as food
KW - Feces
KW - Korea (South)
N1 - Accession Number: 23564664; Yun-Sook Kang 1,2; Yong-Sun Do 3; Sun-Kyung Yoon 1; Myeong-Ae Yu 4; Chang-Min Kim 5; Jong-Ok Lee 2; Yu-Ryang Pyuni 1; Email Address: yrpyun@yonsei.ac.kr.; Affiliations: 1: Department of Biotechnology, Yonsei University, Seoul, 120-749, Korea; 2: Korea Food and Drug Administration Seoul, 122-704, Korea; 3: Food Analysis Research Team, Korea Food Research Institute, Gyunggi-do, 463-746, Korea; 4: lnternational Life Sciences Institute of Korea, Seoul, 150-889, Korea; 5: Dongwon F&B Food R&D Center, Gyunggi-do, 462-120, Korea; Issue Info: Dec2006, Vol. 69 Issue 12, p2915; Thesaurus Term: Campylobacter; Thesaurus Term: Campylobacter jejuni; Thesaurus Term: Contamination (Technology); Subject Term: Poultry as food; Subject Term: Feces; Subject: Korea (South); NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 9p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Patel, Manish M.
AU - Schier, Joshua G.
T1 - Medical Toxicology and Public Health: Update on Research and Activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry.
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
Y1 - 2006/12//
VL - 2
IS - 4
M3 - Article
SP - 169
EP - 169
SN - 15569039
AB - The article presents an update on research and activities involving medical toxicologists at the National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry at the U.S. Centers for Disease Control and Prevention (CDC). The public health strategies of the CDC to define and mitigate aflatoxin-related morbidity and mortality in developing countries are being developed by medical toxicologists and epidemiologists in the Health Studies Branch and international mycotoxin experts.
KW - TOXICOLOGY
KW - TOXICOLOGISTS
KW - MEDICAL scientists
KW - PUBLIC health
KW - AFLATOXINS
KW - MYCOTOXINS
KW - DEVELOPING countries
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 22972166; Patel, Manish M. 1 Schier, Joshua G. 1; Affiliation: 1: Lieutenant Commander, U.S. Public Health Service: Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention; Source Info: Dec2006, Vol. 2 Issue 4, p169; Subject Term: TOXICOLOGY; Subject Term: TOXICOLOGISTS; Subject Term: MEDICAL scientists; Subject Term: PUBLIC health; Subject Term: AFLATOXINS; Subject Term: MYCOTOXINS; Subject Term: DEVELOPING countries; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106299361
T1 - Spirituality and depressive symptoms in a racially diverse US sample of community-dwelling adults.
AU - Mofidi M
AU - DeVellis RF
AU - Blazer DG
AU - DeVellis BM
AU - Panter AT
AU - Jordan JM
Y1 - 2006/12//
N1 - Accession Number: 106299361. Language: English. Entry Date: 20070608. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D); Daily Spiritual Experiences Scale (DSES) (Underwood and Teresi). Grant Information: Supported in part by National Institute of Mental Health grant RO1 MH64034-02, and Centers for Disease Control and Prevention/Association of Schools of Public Health S043, S1734, and S3486, and NIAMS Multipurpose Arthritis and Musculoskeletal Disease Center 5-P60-AR30701. NLM UID: 0375402.
KW - Blacks -- Psychosocial Factors
KW - Depression -- Diagnosis
KW - Spirituality
KW - Whites -- Psychosocial Factors
KW - Adult
KW - Center for Epidemiological Studies Depression Scale
KW - Comparative Studies
KW - Cross Sectional Studies
KW - Data Collection
KW - Depression -- Epidemiology
KW - Depression -- Psychosocial Factors
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Interviews
KW - Life Change Events
KW - Male
KW - Middle Age
KW - North Carolina
KW - Probability Sample
KW - Psychological Tests
KW - Questionnaires
KW - Scales
KW - Sex Factors
KW - Stress, Psychological -- Diagnosis
KW - Stress, Psychological -- Epidemiology
KW - Stress, Psychological -- Psychosocial Factors
KW - Structural Equation Modeling
KW - Surveys
KW - T-Tests
KW - United States
KW - Human
SP - 975
EP - 977
JO - Journal of Nervous & Mental Disease
JF - Journal of Nervous & Mental Disease
JA - J NERV MENT DIS
VL - 194
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The role of spirituality in depression is understudied. We examined the relationship between one dimension of spirituality, spiritual experiences, and depressive symptoms, and evaluated whether differences in gender, race, age, and stress moderated the relationship. The study was conducted with a community-based sample of 630 racially diverse middle-aged and older adults. Structural equation modeling was used to estimate a model linking spiritual experiences to depressive symptoms while controlling for demographic and health variables. Spiritual experiences were operationalized using six items of the Daily Spiritual Experiences Scale. Sample items included, 'I feel God's presence,' and, 'I feel comfort in my religion or spirituality.' The model achieved satisfactory goodness of fit. Spiritual experiences were significantly associated with fewer depressive symptoms, and age as well as stress moderated the association, but not gender and race. Spirituality appears to be a psychosocial resource against depressive symptoms, although the results must be confirmed in longitudinal investigations.
SN - 0022-3018
AD - Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland, USA.
U2 - PMID: 17164640.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106299361&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106112206
T1 - Impact of silanol surface density on the toxicity of silica aerosols measured by erythrocyte haemolysis.
AU - Murashov V
AU - Harper M
AU - Demchuk E
Y1 - 2006/12//
N1 - Accession Number: 106112206. Language: English. Entry Date: 20070629. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Aerosols
KW - Erythrocytes -- Drug Effects
KW - Hemolysis -- Drug Effects
KW - Oxides
KW - Silicon Compounds
KW - Chemistry
KW - Surface Properties
KW - Human
SP - 718
EP - 723
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 3
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Exposures to silica-containing dusts are associated with a risk of developing life-threatening lung diseases. However, the mechanism of silica toxicity is poorly understood. In this work the atomic structure of the surfaces of different silica polymorphs was determined, and a relationship with in vitro silica toxicity was examined. The density of geminal and single silanol groups was quantitatively estimated for different silica polymorphs using a novel molecular modeling method. An association was found between the reported haemolytic activity and modeled densities of surface geminal (but not single) silanol groups on several silica polymorphs. These findings suggest a new view of aerosol toxicity based on the estimation of surface site densities. The results can be used in the development of new toxicological assays for respirable particulates, including nanomaterials.
SN - 1545-9624
AD - Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. vem8@cdc.gov
U2 - PMID: 17133693.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106112206&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109848966
T1 - Using evidence-based indicators and health information technology to improve the safety, accountability, and quality of emergency room care.
AU - Clancy CM
Y1 - 2006/12//2006 Dec
N1 - Accession Number: 109848966. Language: English. Entry Date: 20080418. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Emergency Service -- Standards
KW - Institute of Medicine (U.S.)
KW - Patient Safety
KW - Collaboration
KW - Information Technology
KW - Professional Practice, Evidence-Based
KW - Reports
SP - 177
EP - 178
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 2
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, US Department of Health and Human Services, 540 Gaither Rd, Rockville, MD 20850; cclancy@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106112223
T1 - Informed choice in screening programmes: do leaflets help? A critical literature review.
AU - Fox R
Y1 - 2006/12//
N1 - Accession Number: 106112223. Language: English. Entry Date: 20070629. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Europe; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 101188638.
KW - Decision Making, Patient
KW - Health Screening -- United Kingdom
KW - Pamphlets
KW - British Nursing Index
KW - CINAHL Database
KW - Clinical Trials
KW - Genetic Screening
KW - Medline
KW - Pancreatic Neoplasms -- Prevention and Control
KW - Prenatal Diagnosis
KW - Prostatic Neoplasms -- Prevention and Control
KW - United Kingdom
KW - Human
SP - 309
EP - 317
JO - Journal of Public Health
JF - Journal of Public Health
JA - J PUBLIC HEALTH
VL - 28
IS - 4
PB - Oxford University Press / USA
SN - 1741-3842
AD - National Public Health Service for Wales, Temple of Peace and Health Cathays Park, Cardiff CF10 3NW, UK.
U2 - PMID: 17060352.
DO - pubmed/fdl066
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106112223&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Myers, Matthew R.
T1 - Long-time temperature rise due to absorption of focused Gaussian beams in tissue.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2006/12//
VL - 120
IS - 6
M3 - Article
SP - 4064
EP - 4070
SN - 00014966
AB - An analytical technique previously developed to study tissue displacement due to acoustic radiation force is extended to analyze temperature rise in tissue for exposure times that are comparable to, or longer than, the tissue perfusion time. A focused transducer with Gaussian amplitude shading is assumed to radiate into a perfused tissue medium with constant thermal and acoustic properties. A simple closed-form expression is derived for the steady-state temperature rise, and a transient correction term is constructed that allows for computation of the equilibrium time of the medium. Comparisons with temperature calculations for non-Gaussian transducers show that the model may be applied to more general intensity profiles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACOUSTIC radiation pressure
KW - SOUND pressure
KW - SOUND waves
KW - GAUSSIAN processes
KW - PERFUSION (Physiology)
KW - TRANSDUCERS
N1 - Accession Number: 23321720; Myers, Matthew R. 1; Affiliation: 1: Center for Devices and Radiological Health, HFZ-170, U. S. Food and Drug Administration, Rockville, Maryland 20852; Source Info: Dec2006, Vol. 120 Issue 6, p4064; Subject Term: ACOUSTIC radiation pressure; Subject Term: SOUND pressure; Subject Term: SOUND waves; Subject Term: GAUSSIAN processes; Subject Term: PERFUSION (Physiology); Subject Term: TRANSDUCERS; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; Number of Pages: 7p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1121/1.2359695
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23321720&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106228127
T1 - Dietary supplements in a national survey: prevalence of use and reports of adverse events.
AU - Timbo BB
AU - Ross MP
AU - McCarthy PV
AU - Lin CJ
Y1 - 2006/12//
N1 - Accession Number: 106228127. Language: English. Entry Date: 20070202. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Instrumentation: Health and Diet Survey. NLM UID: 7503061.
KW - Dietary Supplements -- Adverse Effects
KW - Dietary Supplements -- Therapeutic Use
KW - Adolescence
KW - Adult
KW - Chi Square Test
KW - Data Analysis Software
KW - Female
KW - Interviews
KW - Male
KW - Medicine, Herbal
KW - Middle Age
KW - Minerals -- Therapeutic Use
KW - Plants, Medicinal -- Therapeutic Use
KW - Questionnaires
KW - Vitamins -- Therapeutic Use
KW - Human
SP - 1966
EP - 1974
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 106
IS - 12
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Health Scientist, Epidemiology Team, Office of Scientific Analysis and Support, US Food and Drug Administration, HFS-728, 5100 Paint Branch Pkwy, College Park, MD 20740; btimbo@cfsan.fda.gov
U2 - PMID: 17126626.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cooper, Glinda S.
AU - Parks, Christine G.
AU - Schur, Peter S.
AU - Fraser, Patricia A.
T1 - Occupational and Environmental Associations with Antinuclear Antibodies in a General Population Sample*.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2006/12//
VL - 69
IS - 23
M3 - Article
SP - 2063
EP - 2069
SN - 15287394
AB - Antinuclear antibodies are a hallmark feature of the autoimmune disease systemic lupus erythematosus, and can occur many years before onset of symptoms. The objective of this study was to examine the association between exposures and high-titer antinuclear antibodies in the general population (i.e., people who do not have lupus or other systemic autoimmune diseases). Serum was collected from 266 population-based controls who had been frequency-matched to the age and gender distribution of lupus cases in a 60-county study area in the southeastern United States. A detailed occupational history was collected using a structured interview; information was also collected on hair dye use. Antinuclear antibodies were assayed using HEp-2 cells as substrate. Logistic regression was used to estimate the odds ratio (OR) as a measure of association between exposures and high-titer antinuclear antibody levels, adjusting for age, gender, and race. High-titer antinuclear antibodies (≥⃒1:160) were observed in 21 subjects (8%). A twofold increased prevalence of high-titer antinuclear antibodies was seen with some occupational exposures (silica dust, pesticides, and sunlight), although none of these individual estimates were statistically significant. The association seen with use of hair dyes was weaker (OR 1.4). There was a suggestion of a dose response with a combined measure based on the summation of exposures (ORs of 1.7, 2.1, and 5.9 for 1, 2, and ≥⃒ 3 exposures). These data suggest that occupational exposures may influence the expression of antinuclear antibodies. Larger studies addressing these exposures may provide insights into the mechanisms by which various environmental factors affect the development of autoantibodies and the progression to clinical disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA antibodies
KW - ENVIRONMENTAL exposure
KW - INDUSTRIAL toxicology
KW - SYSTEMIC lupus erythematosus
KW - HEALTH risk assessment
KW - AUTOIMMUNE diseases
KW - ENVIRONMENTAL health research
KW - LOGISTIC regression analysis
KW - ANTINUCLEAR factors
KW - UNITED States
N1 - Accession Number: 22897858; Cooper, Glinda S. 1; Email Address: gscooper1@gmail.com Parks, Christine G. 2 Schur, Peter S. 3 Fraser, Patricia A. 4; Affiliation: 1: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Brigham and Women's Hospital, Boston, Massachusetts, USA 4: Center for Blood Research, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA; Source Info: Dec2006, Vol. 69 Issue 23, p2063; Subject Term: DNA antibodies; Subject Term: ENVIRONMENTAL exposure; Subject Term: INDUSTRIAL toxicology; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: HEALTH risk assessment; Subject Term: AUTOIMMUNE diseases; Subject Term: ENVIRONMENTAL health research; Subject Term: LOGISTIC regression analysis; Subject Term: ANTINUCLEAR factors; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/15287390600746165
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22897858&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MARTINEZ, M. N.
AU - KAWALEK, J. C.
AU - HOWARD, K. D.
AU - WARD, J. L.
AU - MARROUM, P.
AU - MARNANE, W.
AU - BENSLEY, D.
AU - PELSOR, F. R.
AU - HOAG, S.
AU - TATAVARTI, A. S.
AU - XIE, L.
AU - FAHMY, R.
T1 - Comparison of bovine in vivo bioavailability of two sulfamethazine oral boluses exhibiting different in vitro dissolution profiles.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/12//
VL - 29
IS - 6
M3 - Article
SP - 459
EP - 467
PB - Wiley-Blackwell
SN - 01407783
AB - The bolus (or oblet) is a dosage form that can be used for the oral administration of pharmaceutical compounds to ruminating species. Unlike traditional tablets, oral boluses may contain quantities of drug on the order of grams rather than milligrams. Due to its size, it is only recently that USP-like in vitro dissolution methods have been developed for this dosage form. However, whether or not these dissolution tests can predict product in vivo performance has yet to be determined. The importance of this issue is apparent when the U.S. Food and Drug Administration Center for Veterinary Medicine is faced with the decision of whether to require additional in vivo bioequivalence study data to support the approval of changes in product chemistry or manufacturing method. The current study was undertaken to determine whether an in vivo/ in vitro correlation can be established for bovine sulfamethazine oral boluses and to acquire insight into the magnitude of changes in in vitro product performance that can occur before corresponding changes are seen in in vivo blood level profiles. Based upon the results of this investigation, it is concluded that marked changes in in vitro sulfamethazine bolus performance can be tolerated before resulting in altered in vivo blood level profiles. However, the data also suggest that rumenal absorption may occur for some compounds. Therefore the degree to which variation in product in vitro dissolution profiles can be tolerated may be compound specific. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSAGE forms of drugs
KW - RUMINATION (Digestion)
KW - DRUGS -- Therapeutic equivalency
KW - BIOAVAILABILITY
KW - CENTER for Veterinary Medicine (U.S.)
N1 - Accession Number: 22930987; MARTINEZ, M. N. 1; Email Address: marilyn.martinez@fda.hhs.gov KAWALEK, J. C. 2 HOWARD, K. D. 2 WARD, J. L. 2 MARROUM, P. 3 MARNANE, W. 1 BENSLEY, D. 1 PELSOR, F. R. 1 HOAG, S. 4 TATAVARTI, A. S. 4 XIE, L. 4 FAHMY, R. 1; Affiliation: 1: *FDA Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD 2: FDA Center for Veterinary Medicine, Office of Research, Laurel, MD 3: FDA Center for Drug Evaluation and Research, Office of Clinical Pharmacology, Silver Spring, MD 4: University of Maryland School of Pharmacy, Baltimore, MD, USA; Source Info: Dec2006, Vol. 29 Issue 6, p459; Subject Term: DOSAGE forms of drugs; Subject Term: RUMINATION (Digestion); Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: BIOAVAILABILITY; Company/Entity: CENTER for Veterinary Medicine (U.S.); Number of Pages: 9p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00781.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22930987&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SHAIKH, B.
AU - RUMMEL, N.
AU - GIESEKER, C.
AU - REIMSCHUESSEL, R.
T1 - Metabolism and depletion of albendazole in the muscle tissue of channel catfish following oral treatment.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2006/12//
VL - 29
IS - 6
M3 - Article
SP - 525
EP - 530
PB - Wiley-Blackwell
SN - 01407783
AB - The residue depletion of albendazole (ABZ) and its metabolites was studied in channel catfish muscle tissue. Channel catfish were dosed once with 10 mg/kg ABZ via stomach tube with manual restraint. Muscle tissue samples were collected at 8, 16, 24, 48, 72, 96 and 120 h postdose. A high-performance liquid chromatographic method was used to assay ABZ and its major metabolites: ABZ sulfoxide (ABZ-SO), ABZ sulfone (ABZ-SO2) and ABZ aminosulfone (ABZ-2-NH2SO2) in the muscle tissue. The results indicate that ABZ and ABZ-SO were present in low concentrations, i.e. <15 and <10 μg/kg, respectively, at 8 h postdose in catfish muscle with and without skin. ABZ-SO2 was present at 1 μg/kg concentration levels until 48 h in muscle alone and 72 h in muscle with skin. ABZ-2-NH2SO2 was not detected at any withdrawal periods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHANNEL catfish
KW - MUSCLES
KW - METABOLISM
KW - ALBENDAZOLE
KW - METABOLITES
N1 - Accession Number: 22930978; SHAIKH, B. 1; Email Address: badaruddin.shaikh@fda.hhs.gov RUMMEL, N. 1 GIESEKER, C. 1 REIMSCHUESSEL, R. 1; Affiliation: 1: Food and Drug Administration, CVM/Office of Research, Laurel, MD, USA; Source Info: Dec2006, Vol. 29 Issue 6, p525; Subject Term: CHANNEL catfish; Subject Term: MUSCLES; Subject Term: METABOLISM; Subject Term: ALBENDAZOLE; Subject Term: METABOLITES; Number of Pages: 6p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2006.00799.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22930978&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burgess-Limerick, R.
AU - Steiner, L.
T1 - Injuries associated with continuous miners, shuttle cars, load–haul–dump and personnel transport in New South Wales underground coal mines.
JO - Mining Technology
JF - Mining Technology
Y1 - 2006/12//
VL - 115
IS - 4
M3 - Article
SP - 160
EP - 168
PB - Taylor & Francis Ltd
SN - 14749009
AB - In the three years to June 2005, 959 injuries associated with continuous miners (CMs), shuttle cars (SCs), load–haul–dump and personnel transport (PT) were reported by NSW underground coal mines, comprising 23% of all injuries reported. The present paper reports an analysis of the narrative field accompanying these reports to determine opportunities for controlling injury risks. The most common combinations of activity and mechanism were: strain while handling CM cable (96 injuries); caught between or struck by moving parts while bolting on a CM (86 injuries); strains while bolting on CM (54 injuries); and slipping off a CM during access, egress or other activity (60 injuries). For the other equipment considered, the common injury mechanism was the vehicle running over a pothole or other roadway abnormality causing the driver or passengers to be injured (169 injuries). Potential control measures include: monorails for CM services; hydraulic cable reelers; handrails on CM platforms; redesign of CM platforms and bolting rigs to reduce reach distances during drilling and bolting; improvements to guarding of bolting controls; standardisation and shape coding of bolting controls; two handed fast feed; improvements in underground roadway maintenance, vehicle suspension, visibility and seating; and pedestrian proximity warning devices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mining Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINERS
KW - WOUNDS & injuries
KW - SHUTTLE cars (Mine haulage)
KW - COAL mines & mining
KW - MINE accidents
KW - MINERAL industries
KW - NEW South Wales
KW - Development equipment
KW - Ergonomics
KW - INJURY
KW - UNDERGROUND COAL
N1 - Accession Number: 23136586; Burgess-Limerick, R. 1; Email Address: robin@hms.uq.edu.au Steiner, L. 2; Affiliation: 1: School of Human Movement Studies, The University of Queensland, Australia 2: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, USA; Source Info: Dec2006, Vol. 115 Issue 4, p160; Subject Term: MINERS; Subject Term: WOUNDS & injuries; Subject Term: SHUTTLE cars (Mine haulage); Subject Term: COAL mines & mining; Subject Term: MINE accidents; Subject Term: MINERAL industries; Subject Term: NEW South Wales; Author-Supplied Keyword: Development equipment; Author-Supplied Keyword: Ergonomics; Author-Supplied Keyword: INJURY; Author-Supplied Keyword: UNDERGROUND COAL; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; Number of Pages: 9p; Illustrations: 4 Diagrams, 7 Charts; Document Type: Article
L3 - 10.1179/174328606X151033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei, Nan
AU - Arlt, Volker M.
AU - Phillips, David H.
AU - Heflich, Robert H.
AU - Chen, Tao
T1 - DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2006/12//
VL - 602
IS - 1/2
M3 - Article
SP - 83
EP - 91
SN - 00275107
AB - Abstract: Aristolochic acid (AA) is a potent nephrotoxin and carcinogen and is the causative factor for Chinese herb nephropathy. AA has been associated with the development of urothelial cancer in humans, and kidney and forestomach tumors in rodents. To investigate the molecular mechanisms responsible for the tumorigenicity of AA, we determined the DNA adduct formation and mutagenicity of AA in the liver (nontarget tissue) and kidney (target tissue) of Big Blue rats. Groups of six male rats were gavaged with 0, 0.1, 1.0 and 10.0mgAA/kg body weight five times/week for 3 months. The rats were sacrificed 1 day after the final treatment, and the livers and kidneys were isolated. DNA adduct formation was analyzed by 32P-postlabeling and mutant frequency (MF) was determined using the λ Select-cII Mutation Detection System. Three major adducts (7-[deoxyadenosin-N 6-yl]-aristolactam I, 7-[deoxyadenosin-N 6-yl]-aristolactam II and 7-[deoxyguanosin-N 2-yl]-aristolactam I) were identified. There were strong linear dose-responses for AA-induced DNA adducts in treated rats, ranging from 25 to 1967adducts/108 nucleotides in liver and 95–4598adducts/108 nucleotides in kidney. A similar trend of dose-responses for mutation induction also was found, the MFs ranging from 37 to 666×10−6 in liver compared with the MFs of 78–1319×10−6 that we previously reported for the kidneys of AA-treated rats. Overall, kidneys had at least two-fold higher levels of DNA adducts and MF than livers. Sequence analysis of the cII mutants revealed that there was a statistically significant difference between the mutation spectra in both kidney and liver of AA-treated and control rats, but there was no significant difference between the mutation spectra in AA-treated livers and kidneys. A:T→T:A transversion was the predominant mutation in AA-treated rats; whereas G:C→A:T transition was the main type of mutation in control rats. These results indicate that the AA treatment that eventually results in kidney tumors in rats also results in significant increases in DNA adduct formation and cII MF in kidney. Although the same treatment does not produce tumors in rat liver, it does induce DNA adducts and mutations in this tissue, albeit at lower levels than in kidney. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MURIDAE
KW - MUTATION (Biology)
KW - DNA
KW - KIDNEY diseases
KW - Aristolochic acid
KW - DNA adduct
KW - Mutagenicity
KW - Transgenic rat
N1 - Accession Number: 23052556; Mei, Nan 1; Email Address: nan.mei@fda.hhs.gov Arlt, Volker M. 2 Phillips, David H. 2 Heflich, Robert H. 1 Chen, Tao 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK; Source Info: Dec2006, Vol. 602 Issue 1/2, p83; Subject Term: MURIDAE; Subject Term: MUTATION (Biology); Subject Term: DNA; Subject Term: KIDNEY diseases; Author-Supplied Keyword: Aristolochic acid; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Transgenic rat; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2006.08.004
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Lin, Guixian
AU - He, Xuming
AU - Ji, Hanlee
AU - Shi, Leming
AU - Davis, Ronald W.
AU - Zhong, Sheng
T1 - Reproducibility Probability Score—incorporating measurement variability across laboratories for gene selection.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2006/12//
VL - 24
IS - 12
M3 - Letter
SP - 1476
EP - 1477
SN - 10870156
AB - A letter to the editor regarding an article on gene expression in a previous issue is presented.
KW - RESEARCH
KW - Letters to the editor
KW - Gene expression
N1 - Accession Number: 23358441; Lin, Guixian 1; He, Xuming 1; Ji, Hanlee 2; Shi, Leming 3; Davis, Ronald W. 4,5; Zhong, Sheng 6,7,8,9; Email Address: szhong@uiuc.edu; Affiliations: 1: Department of Statistics, University of Illinois, Urbana-Champaign, 725 S. Wright St., Champaign, Illinois 61820, USA; 2: Department of Medicine, Stanford University School of Medicine, 318 Campus Drive, Stanford, California 94305, USA; 3: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; 4: Department of Biochemistry, Stanford University School of Medicine, 318 Campus Drive, Stanford, California 94305, USA; 5: Department of Genetics, Stanford University School of Medicine, 318 Campus Drive, Stanford, California 94305, USA; 6: 5Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, llinois 61801, USA; 7: Department Statistics, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, llinois 61801, USA; 8: Department Computer Science, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, llinois 61801, USA; 9: Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, llinois 61801, USA; Issue Info: Dec2006, Vol. 24 Issue 12, p1476; Thesaurus Term: RESEARCH; Subject Term: Letters to the editor; Subject Term: Gene expression; Number of Pages: 2p; Illustrations: 1 Diagram; Document Type: Letter
L3 - 10.1038/nbt1206-1476
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Elaine R.
AU - Woo, Emily Jane
T1 - Time to prevent injuries from postimmunization syncope.
JO - Nursing
JF - Nursing
Y1 - 2006/12//
VL - 36
IS - 12
M3 - Article
SP - 20
EP - 20
PB - Lippincott Williams & Wilkins
SN - 03604039
AB - The article offers information about managing post-immunization syncope. After one undergoes immunization, pain, anxiety, or trauma can trigger vasovagal reactions causing sudden dizziness or syncope. Thus, a nurse must take significant measures to promote patient safety, even during a procedure as seemingly simple as giving an immunization injection. Safety measures implemented could mean the difference between life and death.
KW - SYNCOPE (Pathology)
KW - LOSS of consciousness
KW - IMMUNIZATION
KW - NURSING services
KW - NURSES
KW - NURSING
KW - MEDICAL care
N1 - Accession Number: 23178813; Miller, Elaine R. 1 Woo, Emily Jane 2; Affiliation: 1: Nurse-epidemiologist, Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Ga. 2: Medical Officer, Food and Drug Administration, Rockville, Md.; Source Info: Dec2006, Vol. 36 Issue 12, p20; Subject Term: SYNCOPE (Pathology); Subject Term: LOSS of consciousness; Subject Term: IMMUNIZATION; Subject Term: NURSING services; Subject Term: NURSES; Subject Term: NURSING; Subject Term: MEDICAL care; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whiteman, Maura K.
AU - Kuklina, Elena
AU - Hillis, Susan D.
AU - Jamieson, Denise J.
AU - Meikle, Susan F.
AU - Posner, Samuel F.
AU - Marchbanks, Folly A.
T1 - Incidence and Determinants of Peripartum Hysterectomy.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2006/12//
VL - 108
IS - 6
M3 - Article
SP - 1486
EP - 1492
SN - 00297844
AB - The article discusses a study designed to provide a U.S.-wide estimate of the incidence of peripartum hysterectomy and to examine factors associated with the procedure. Assessment of data for 1998-2003 from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample suggests that vaginal birth after cesarean, primary care and repeat cesarean deliveries, and multiple births are independently associated with an increased risk for peripartum hysterectomy.
KW - VAGINAL hysterectomy
KW - SURGERY -- Risk factors
KW - HOSPITAL utilization
KW - PRIMARY care (Medicine)
KW - CESAREAN section
KW - MULTIPLE birth
KW - UNITED States
N1 - Accession Number: 23472413; Whiteman, Maura K. 1; Email Address: acq5@cdc.gov Kuklina, Elena 1 Hillis, Susan D. 1 Jamieson, Denise J. 1 Meikle, Susan F. 1 Posner, Samuel F. 1 Marchbanks, Folly A. 1; Affiliation: 1: From the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia; Comforce Technical Services Inc., Los Angeles, California; and Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Dec2006, Vol. 108 Issue 6, p1486; Subject Term: VAGINAL hysterectomy; Subject Term: SURGERY -- Risk factors; Subject Term: HOSPITAL utilization; Subject Term: PRIMARY care (Medicine); Subject Term: CESAREAN section; Subject Term: MULTIPLE birth; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Charles, L. E.
AU - Burchfiel, C. M.
AU - Fekedulegn, D.
AU - Kashon, M. I.
AU - Ross, G. W.
AU - Sanderson, W. I.
AU - Petrovitch, H.
T1 - Occupational and other risk factors for hand-grip strength: the Honolulu-Asia Aging Study.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2006/12//
VL - 63
IS - 12
M3 - Article
SP - 820
EP - 827
SN - 13510711
AB - Background: In certain occupations, including farm work, workers are exposed to hazardous substances, some of which are known to be toxic to the nervous system and may adversely affect muscle strength. Measurement of hand-grip strength may be useful for detecting neurotoxic exposure. Methods: The authors studied 3522 participants of the Honolulu Heart Program and the Honolulu-Asia Aging Study to determine whether occupational exposures to pesticides, solvents, and metals assessed at exam 1(1965-68) are associated with hand-grip strength at exam IV (1991-93) and change in hand-grip strength over 25 years. Correlation, analysis of variance and covariance, and linear regression were used to evaluate the associations. Results: At exam IV, participants ranged in age from 71-93 years; mean hand-grip strength was 39.6 kg at exam I and 30.3 kg at exam IV. Over 25 years, the decline in hand-grip strength was an average of 8-9 kg for all exposures. Hand-grip strength was inversely associated with age and glucose but directly associated with cognitive function, BMI, and haemoglobin level. No other exposures were associated with hand-grip strength. Conclusion: This study did not provide evidence that occupational exposure to pesticides, solvents, and metals adversely affected hand-grip strength in this population, but confirmed other important associations with hand-grip strength. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational hazards
KW - Industrial safety
KW - Neurotoxic agents
KW - Threshold limit values (Industrial toxicology)
KW - Neurotoxicology
KW - Muscle strength
KW - Grip strength
KW - Cognitive ability
KW - Analysis of variance
KW - Regression analysis
N1 - Accession Number: 23558856; Charles, L. E. 1; Email Address: lcharles@cdc.gov; Burchfiel, C. M. 1; Fekedulegn, D. 1; Kashon, M. I. 1; Ross, G. W. 2,3,4,5; Sanderson, W. I. 6; Petrovitch, H. 2,3,4,5; Affiliations: 1: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA; 2: Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA; 3: The Pacific Health Research Institute, Honolulu, HI, USA; 4: Departments of Geriatric Medicine and Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA; 5: Kuakini Medical Center and the Honolulu-Asia Aging Study, Honolulu, HI, USA; 6: Department of Occupational and Environmental Health, the University of Iowa College of Public Health, Iowa City, IA, USA; Issue Info: Dec2006, Vol. 63 Issue 12, p820; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial safety; Thesaurus Term: Neurotoxic agents; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Neurotoxicology; Subject Term: Muscle strength; Subject Term: Grip strength; Subject Term: Cognitive ability; Subject Term: Analysis of variance; Subject Term: Regression analysis; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1136/oem.2006.027813
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106122356
T1 - Occupational and other risk factors for hand-grip strength: the Honolulu-Asia Aging Study.
AU - Charles LE
AU - Burchfiel CM
AU - Fekedulegn D
AU - Kashon ML
AU - Ross GW
AU - Sanderson WT
AU - Petrovitch H
AU - Charles, L E
AU - Burchfiel, C M
AU - Fekedulegn, D
AU - Kashon, M L
AU - Ross, G W
AU - Sanderson, W T
AU - Petrovitch, H
Y1 - 2006/12//
N1 - Accession Number: 106122356. Language: English. Entry Date: 20070720. Revision Date: 20161114. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Instrumentation: Cognitive Abilities Screening Index Instrument (CASI). Grant Information: 1-R01-AG17155-01A1/AG/NIA NIH HHS/United States. NLM UID: 9422759.
KW - Grip Strength -- In Old Age
KW - Metals -- Adverse Effects
KW - Occupational Exposure -- Adverse Effects
KW - Pesticides -- Adverse Effects
KW - Solvents -- Adverse Effects
KW - Aged
KW - Aged, 80 and Over
KW - Analysis of Covariance
KW - Analysis of Variance
KW - Correlational Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Dynamometry
KW - Funding Source
KW - Hawaii
KW - Japanese
KW - Linear Regression
KW - Male
KW - Neuropsychological Tests
KW - Prospective Studies
KW - T-Tests
KW - Univariate Statistics
KW - Human
SP - 820
EP - 827
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 63
IS - 12
PB - BMJ Publishing Group
AB - Background: In certain occupations, including farm work, workers are exposed to hazardous substances, some of which are known to be toxic to the nervous system and may adversely affect muscle strength. Measurement of hand-grip strength may be useful for detecting neurotoxic exposure.Methods: The authors studied 3522 participants of the Honolulu Heart Program and the Honolulu-Asia Aging Study to determine whether occupational exposures to pesticides, solvents, and metals assessed at exam I (1965-68) are associated with hand-grip strength at exam IV (1991-93) and change in hand-grip strength over 25 years. Correlation, analysis of variance and covariance, and linear regression were used to evaluate the associations.Results: At exam IV, participants ranged in age from 71-93 years; mean hand-grip strength was 39.6 kg at exam I and 30.3 kg at exam IV. Over 25 years, the decline in hand-grip strength was an average of 8-9 kg for all exposures. Hand-grip strength was inversely associated with age and glucose but directly associated with cognitive function, BMI, and haemoglobin level. No other exposures were associated with hand-grip strength.Conclusion: This study did not provide evidence that occupational exposure to pesticides, solvents, and metals adversely affected hand-grip strength in this population, but confirmed other important associations with hand-grip strength.
SN - 1351-0711
AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA
AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2888, USA. lcharles@cdc.gov
U2 - PMID: 16912086.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105692465
T1 - Deferasirox for the treatment of chronic iron overload in transfusional hemosiderosis.
AU - Shashaty G
AU - Frankewich R
AU - Chakraborti T
AU - Choudary J
AU - Al-Fayoumi S
AU - Kacuba A
AU - Castillo S
AU - Robie-Suh K
AU - Rieves D
AU - Weiss K
AU - Pazdur R
Y1 - 2006/12//
N1 - Accession Number: 105692465. Language: English. Entry Date: 20081121. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8712059.
KW - Acids, Carbocyclic -- Therapeutic Use
KW - Blood Transfusion
KW - Chelating Agents -- Therapeutic Use
KW - Hemosiderosis -- Drug Therapy
KW - Heterocyclic Compounds -- Therapeutic Use
KW - Iron Overload -- Drug Therapy
KW - Thalassemia -- Drug Therapy
KW - Adolescence
KW - Adult
KW - Child
KW - Child, Preschool
KW - Clinical Trials
KW - Deferoxamine -- Therapeutic Use
KW - Female
KW - Hemosiderosis -- Complications
KW - Iron Overload -- Etiology
KW - Iron -- Metabolism
KW - Male
KW - Middle Age
KW - Thalassemia -- Complications
KW - Human
SP - 1799
EP - 1806
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 20
IS - 14
CY - Norwalk, Connecticut
PB - UBM Medica
AB - Purpose: This report describes the Food and Drug Administration's review of data and analyses leading to the approval of the oral iron chelator, deferasirox for the treatment of chronic iron overload due to transfusional hemosiderosis.Experimental Design: The FDA reviewed findings of a controlled, open-label, randomized multicenter phase III study of deferasirox vs deferoxamine in 586 patients with beta-thalessemia and transfusional hemosiderosis. The study results as well as the results of the FDA review of chemistry, preclinical pharmacology, and supportive studies are described.Results: Following 48 weeks of treatment in the phase III study, patients' liver iron concentrations (a key endpoint variable) had decreased an average of 2.4 mg of iron (Fe)/g dry weight (dw) and 2.9 mg Fe/g dw in the deferasirox and deferoxamine groups, respectively, despite continued blood transfusions in both cohorts. Deferasirox was associated with serum creatinine increases in approximately a third of patients. Common adverse events included gastrointestinal symptoms and skin rash. Other data provided supportive evidence of deferasirox safety and efficacy.Conclusions: The FDA granted deferasirox accelerated approval on November 2, 2005, for use in treating chronic iron overload due to transfusional hemosiderosis in patients >/= 2 years of age. The sponsor must obtain clinical data demonstrating the drug's long-term safety and effectiveness.
SN - 0890-9091
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 17263129.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Landmann, Eva
AU - Geller, Frank
AU - Schilling, Jutta
AU - Rudloff, Silvia
AU - Foeller-Gaudier, Eleonore
AU - Gortner, Ludwig
T1 - Absence of the Wild-type Allele (192 Base Pairs) of a Polymorphism in the Promoter Region of the IGF-I Gene but Not a Polymorphism in the Insulin Gene Variable Number of Tandem Repeat Locus Is Associated With Accelerated Weight Gain in Infancy.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/12//
VL - 118
IS - 6
M3 - Article
SP - 2374
EP - 2379
SN - 00314005
AB - OBJECTIVE. Our goal was to investigate whether a polymorphism in the insulin-lie growth factor I promoter gene (IGF-1, wild-type, 192 base pairs) and in the insulin gene (INS) variable number of tandem repeat locus influence birth weight and weight gain in infancy. PATIENTS AND METHODS. We obtained genomic DNA from 768 children. Exclusion criteria were multiple births, gestational diabetes, maternal diabetes, gestational age <37 weeks, <42 weeks, or unclear, and any condition potentially influencing weight gain. SD scores were calculated and adjusted for gestational age and gender. A gain in SD scores for weight between birth and 1 year >0.67 SD scores was defined as accelerated weight gain. Genotyping was performed by fragment length analysis (IGF-I) and by fragment length analysis after using a restriction enzyme-based assay (INS variable number tandem repeat). RESULTS. Accelerated weight gain present in 205 of 768 children. IGF-I and INS variable number tandem repeat genotype were not associated with birth weight. The IGF-I 192-base pair allele was less frequent in children with accelerated weight gain and was shown to reduce the risk for accelerated weight gain in logistic regression model. CONCLUSION. The IGF-I 192-base pair allele may reduce the risk for rapid weight gain in early infancy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOMATOMEDIN
KW - GENES
KW - BIRTH weight
KW - WEIGHT gain
KW - GESTATIONAL age
KW - GENDER
KW - INFANTS
KW - fetal growth restriction
KW - genetic predisposition
KW - infant
KW - obesity
KW - weight gain
N1 - Accession Number: 23405040; Landmann, Eva 1; Email Address: eva.landmann@paediatmed.uni-giessen.de Geller, Frank 2 Schilling, Jutta 1 Rudloff, Silvia 1 Foeller-Gaudier, Eleonore 3 Gortner, Ludwig 4; Affiliation: 1: Pediatric Center, Department of Pediatrics and Neonatology, Justus-Liebig University Glesson, Glesson, Germany 2: Institute for Medical Biostatistics and Epidemiology, Phillipps University, Marburg, Germany 3: Public Health Service of the City of Glesson, Glesson, Germany 4: Department of Pediatrics and Neonatology, University of Saarland, Homburg/Saar, Germany; Source Info: Dec2006, Vol. 118 Issue 6, p2374; Subject Term: SOMATOMEDIN; Subject Term: GENES; Subject Term: BIRTH weight; Subject Term: WEIGHT gain; Subject Term: GESTATIONAL age; Subject Term: GENDER; Subject Term: INFANTS; Author-Supplied Keyword: fetal growth restriction; Author-Supplied Keyword: genetic predisposition; Author-Supplied Keyword: infant; Author-Supplied Keyword: obesity; Author-Supplied Keyword: weight gain; Number of Pages: 6p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1542/peds.2006-0146
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, Timothy F.
AU - Ingram, L. Amanda
AU - Fullerton, Kathleen E.
AU - Marcus, Ruthanne
AU - Anderson, Bridget J.
AU - McCarthy, Patrick V.
AU - Vugia, Duc
AU - Shiferaw, Beletshachew
AU - Haubert, Nicole
AU - Wedel, Stephanie
AU - Angulo, Frederick J.
T1 - A Case-Control Study of the Epidemiology of Sporadic Salmonella Infection in Infants.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/12//
VL - 118
IS - 6
M3 - Article
SP - 2380
EP - 2387
SN - 00314005
AB - OBJECTIVE. Rates of Salmonella infection are highest in infants, but little is known about potential sources of infection in this high-risk population. We performed a case-control study to identify dietary and environmental risk factors for sporadic salmonellosis among infants. PATIENTS AND METHODS. In 2002-2004, the Foodborne Diseases Active Surveillance Network conducted a population-based, case-control study of sporadic salmonellosis among infants <1 year of age in 8 states. Cases were identified via active laboratory-based surveillance. Healthy controls were frequency matched by age and identified through birth registries or published birth announcements. We assessed diet and environmental exposures in the 5 days before illness onset or interview. Data were analyzed by using logistic regression adjusting for age. RESULTS. The study enrolled 442 subjects and 928 controls. Compared with healthy controls, infants with Salmonella infection were less likely to have been breastfed and more likely to have had exposure to reptiles, to have ridden in a shopping cart next to meat or poultry, or to have consumed concentrated liquid infant formula during the 5-day exposure period. Travel outside file United States was associated with illness in infants 3 to 6 and >6 months of age. Attending day care with a child with diarrhea was associated with salmonellosis in infants >6 months of age. CONCLUSIONS. We identified a number of modifiable protective and risk factors for salmonellosis in infants. Attention should be directed at developing effective preventive measures for this high-risk population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA food poisoning
KW - INFANTS
KW - DIET
KW - TRAVEL
KW - INFANT diseases
KW - UNITED States
KW - epidemiology
KW - infant
KW - Salmonella
N1 - Accession Number: 23405041; Jones, Timothy F. 1; Email Address: tim.f.jones@state.tn.us Ingram, L. Amanda 1 Fullerton, Kathleen E. 2 Marcus, Ruthanne 3 Anderson, Bridget J. 4 McCarthy, Patrick V. 5 Vugia, Duc 6 Shiferaw, Beletshachew 7 Haubert, Nicole 8 Wedel, Stephanie 9 Angulo, Frederick J. 2; Affiliation: 1: Tennessee Department of Health, Nashville, Tennessee 2: Centers for Disease Control and Prevention, Atlanta, Georgia 3: Connecticut Emerging Infections Program, New Haven, Connecticut 4: New York State Department of Health, Albany, New York 5: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 6: California Department of Health Services, Berkeley, California 7: Oregon Department of Human Services, Portland, Oregon 8: Colorado Department of Public Health and Environment, Denver, Colorado 9: Minnesota Department of Health, Minneapolis, Minnesota; Source Info: Dec2006, Vol. 118 Issue 6, p2380; Subject Term: SALMONELLA food poisoning; Subject Term: INFANTS; Subject Term: DIET; Subject Term: TRAVEL; Subject Term: INFANT diseases; Subject Term: UNITED States; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: infant; Author-Supplied Keyword: Salmonella; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2006-1218
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23405041&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calonge, Ned
T1 - Screening for Elevated Blood Lead Levels in Children and Pregnant Women.
JO - Pediatrics
JF - Pediatrics
Y1 - 2006/12//
VL - 118
IS - 6
M3 - Article
SP - 2514
EP - 2518
SN - 00314005
AB - The article presents an overview of an updated recommendation statement about the routine screening for elevated blood lead levels (BLL) in children and pregnant women to be released by the U.S. Preventive Services Task Force (USPSTF). The USPSTF recommends against routine screening for elevated BLL in asymptomatic children aged 1 to 5 years, who are at average risk, and also recommends against routine screening for elevated BLL in asymptomatic pregnant women. Relatively low BLL are associated with neurotoxic effects in children, while severely elevated BLL in symptomatic pregnant women are associated with poor health outcomes.
KW - MEDICAL screening
KW - LEAD
KW - BLOOD analysis
KW - CHILDREN
KW - PREGNANT women
KW - NEUROTOXICOLOGY
KW - HEALTH
KW - UNITED States
KW - evidence-based medicine
KW - lead levels
KW - screening
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 23405062; Calonge, Ned 1; Email Address: uspstf@ahrq.gov; Affiliation: 1: US Preventive Services Task Force, c/o Program Director, USPSTF, Agency for Healthcare Research and Quality, 540 Gaither Rd. MD 20850; Source Info: Dec2006, Vol. 118 Issue 6, p2514; Subject Term: MEDICAL screening; Subject Term: LEAD; Subject Term: BLOOD analysis; Subject Term: CHILDREN; Subject Term: PREGNANT women; Subject Term: NEUROTOXICOLOGY; Subject Term: HEALTH; Subject Term: UNITED States; Author-Supplied Keyword: evidence-based medicine; Author-Supplied Keyword: lead levels; Author-Supplied Keyword: screening; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
L3 - 10.1542/peds.2006-2352
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106233381
T1 - Compliance with well-child visit recommendations: evidence from the Medical Expenditure Panel Survey, 2000-2002.
AU - Selden TM
Y1 - 2006/12//
N1 - Accession Number: 106233381. Language: English. Entry Date: 20070209. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child Health Services -- Utilization
KW - Health Promotion
KW - Patient Compliance
KW - Adolescence
KW - Bivariate Statistics
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Insurance Coverage
KW - Insurance, Health
KW - Interviews
KW - Male
KW - Multivariate Analysis
KW - Poverty
KW - Human
SP - e1766
EP - 78
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 118
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: This study examines national compliance rates with well-child visit recommendations using the Medical Expenditure Panel Survey. The Medical Expenditure Panel Survey provides nationally representative information on preventative care for children, combining visit-level data over a 2-year period with a rich array of socioeconomic and health status measures. METHODS: Visit-level data from 2000 to 2002 were used to construct a well-child visit 'compliance' measure equal to well-child visits as a percentage of age-specific recommendations from the American Academy of Pediatrics. Compliance was examined across age, gender, race/ethnicity, health status, poverty, insurance coverage, eligibility for public coverage, family structure, parent education, insurance, citizenship and country of origin, language, urbanicity, and census division. RESULTS: On average, 56.3% of all children aged 0 to 18 years had no well-child visits during a 12-month period, and 39.4% had no well-child visits over a 2-year period. The average compliance ratio was 61.4%. Large differences in compliance exist among children. High compliance rates were observed among infants (83.2%), children with special health care needs (86.6%), children with college-educated parents (74.3%), children with family incomes >4 times the poverty level (71.6%), and children in the New England (94.6%) and Middle Atlantic (83.2%) census divisions. Low levels of compliance were observed among uninsured children (35.3%) and especially uninsured children simulated to be eligible for public coverage (28.4%). Other groups with low compliance rates include teenagers (49.2%), noncitizen children (43.9%), and children in the West South Central (44.9%), East South Central (48.8%), and Mountain (49.7%) census divisions. CONCLUSIONS: Well-child visit compliance in the Medical Expenditure Panel Survey is less than found in other household surveys, yet consistent with or above results based on data from provider and claims data. Although experts dispute the optimal frequency of well-child visits, the disparities observed in compliance rates among population subgroups raise important public health concerns.
SN - 0031-4005
AD - Division of Modeling and Simulation, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850, USA. tselden@ahrq.gov
U2 - PMID: 17142499.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Xing-Dong Zhang
AU - Andrew, Michael E.
AU - Hubbs, Ann F.
AU - Siegel, Paul D.
T1 - Airway Responses in Brown Norway Rats Following Inhalation Sensitization and Challenge with Trimellitic Anhydride.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2006/12//
VL - 94
IS - 2
M3 - Article
SP - 322
EP - 329
PB - Oxford University Press / USA
SN - 10966080
AB - Trimellitic anhydride (TMA) is a cause of asthma in man. Dose-dependent TMA-specific IgE, histopathology, and airway responses after sensitization by inhalation were examined in the Brown Norway rat. Rats were exposed to 0.04, 0.4, 4, or 40 mg/m3 TMA aerosol for 10 min, once a week, over 10 weeks. All lower exposures were, subsequently, rechallenged to 40 mg/m3 TMA aerosol. All rats received a sham exposure 1 week prior to the first TMA exposure. Following the sham exposure and weekly after each TMA exposure, TMA-specific IgE and both early-phase airway response (EAR) and late-phase airway response (LAR) were measured using enhanced pause (Penh). All rats sensitized by 40 mg/m3 TMA developed specific IgE, EAR, and LAR to one or more of the challenges to 40 mg/m3 TMA. TMA of 4 mg/m3 induced a much lower, but stable, specific IgE response. EAR and LAR were observed only after a 40 mg/m3 TMA rechallenge in this group, but it was much larger than that observed in the 40 mg/m3 TMA-sensitized and challenged group. Exposure-dependent histopathological changes noted included eosinophilic granulomatous interstitial pneumonia, perivascular eosinophil infiltrates, bronchial-associated lymphoid tissue hyperplasia, and peribronchiolar plasma cell infiltrates. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Anhydrides
KW - Eosinophils
KW - Pneumonia
KW - Lymphoid tissue
KW - Hyperplasia
KW - airway response
KW - IgE
KW - inhalation
KW - trimellitic anhydride
N1 - Accession Number: 44406641; Xing-Dong Zhang 1; Andrew, Michael E. 1; Hubbs, Ann F. 1; Siegel, Paul D. 1; Email Address: psiegel@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Issue Info: Dec2006, Vol. 94 Issue 2, p322; Thesaurus Term: Asthma; Subject Term: Anhydrides; Subject Term: Eosinophils; Subject Term: Pneumonia; Subject Term: Lymphoid tissue; Subject Term: Hyperplasia; Author-Supplied Keyword: airway response; Author-Supplied Keyword: IgE; Author-Supplied Keyword: inhalation; Author-Supplied Keyword: trimellitic anhydride; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfl107
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stefaniak, Aleksandr B.
AU - Harvey, Christopher J.
T1 - Dissolution of materials in artificial skin surface film liquids
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2006/12//
VL - 20
IS - 8
M3 - Article
SP - 1265
EP - 1283
SN - 08872333
AB - Abstract: The dissolution of chemical constituents from jewelry, textiles, cosmetics, drugs, industrial chemicals, and particles in direct and prolonged contact with human skin is often assessed in vitro using artificial skin surface film liquids (SSFL). To provide meaningful results, the composition of artificial SSFL should accurately mimic human sweat and sebum, and the conditions of the in vitro test system should accurately reflect in vivo skin conditions. We summarized the reported composition of human SSFL and compared it to 45 different formulations of artificial sweat and 18 formulations of artificial sebum (studies published from 1940 to 2005). Conditions of in vitro dissolution test systems were reviewed and compared to in vivo skin conditions. The concentrations of individual constituents and pH of artificial sweat and concentrations of artificial sebum constituents are not always within ranges reported for human SSFL. Nearly all artificial SSFL lack many of the constituents in human SSFL. To develop a comprehensive model SSFL, we propose a standard SSFL, modified from the two best published sweat and sebum formulations. Little is known concerning the influence of test system conditions on dissolution, including SSFL temperature, container material composition, agitation, and physicochemical properties of the test article on dissolution. Thus, both a need and an opportunity exist for standardizing the composition of artificial SSFL and in vitro dissolution test methodologies. To standardize in vitro dissolution test systems, we recommend: maintaining artificial SSFL at a biologically relevant temperature appropriate to the human activity being modeled, carefully selecting test and sample storage containers to avoid bias in dissolution measurements, accounting for friction between a test article and skin in a biologically plausible manner, and physicochemical characterization of the test article or material to better understand mechanisms of dissolution and potential mechanisms of toxic action of dissolved material. More accurate modeling and better understanding of chemical dissolution from articles in contact with the skin will ultimately improve risk decision making, thereby protecting even the most susceptible persons from adverse health effects resulting from skin exposure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemicals -- Physiological effect
KW - Skin
KW - Perspiration
KW - Sebum
KW - Dermatology
KW - Artificial sebum
KW - Artificial sweat
KW - Dissolution
KW - Human sebum
KW - Human sweat
KW - Skin surface film liquids
N1 - Accession Number: 22736267; Stefaniak, Aleksandr B. 1; Email Address: boq9@cdc.gov; Harvey, Christopher J. 1,2; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop H-2703, Morgantown, WV 26505, United States; 2: Association of Teachers of Preventive Medicine Summer Fellow, Drexel University School of Public Health, Philadelphia, PA 19102, United States; Issue Info: Dec2006, Vol. 20 Issue 8, p1265; Thesaurus Term: Chemicals -- Physiological effect; Subject Term: Skin; Subject Term: Perspiration; Subject Term: Sebum; Subject Term: Dermatology; Author-Supplied Keyword: Artificial sebum; Author-Supplied Keyword: Artificial sweat; Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Human sebum; Author-Supplied Keyword: Human sweat; Author-Supplied Keyword: Skin surface film liquids; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.tiv.2006.05.011
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Atenstaedt, Robert L.
T1 - Trench Foot: The Medical Response in the First World War 1914-18.
JO - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
JF - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
Y1 - 2006///Winter2006
VL - 17
IS - 4
M3 - Article
SP - 282
EP - 289
PB - Allen Press Publishing Services Inc.
SN - 10806032
AB - The approaching 90-year anniversary of United States entry into the Great War is an apt time to examine the response to trench foot (now called nonfreezing cold injury [NFCI]) in this conflict. Trench foot appeared in the winter of 1914, characterized by pedal swelling, numbness, and pain. It was quickly recognized by military-medical authorities. There was little debate over whether it was frostbite or new condition, and it was quickly accepted as a specific disease. The major etiologies proposed were exposure, diet, and infection. The opinion emerged that it was caused by circulatory changes in the foot caused by cold, wet, and pressure. Predisposing factors included dietary inadequacy and fatigue. A number of labels were first given to the disease. However, the name "trench foot" was eventually officially sanctioned. Trench foot became a serious problem for the Allies, leading to 75 000 casualties in the British and 2000 in the American forces. Therapy for trench foot involved a number of conventional, tried-and-tested, and conservative methods. Some more innovative techniques were used. Amputation was only used as a last resort. Prevention involved general measures to improve the trench environment; modification of the footwear worn by the men; and the provision of greases to protect them from moisture. The medical reaction to this condition seems to have been relatively effective. The causation was identified, and prophylactic measures were introduced to fit this model; these seem to have been successful in reducing the prevalence of the condition by 1917-18. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.) is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Trench fever
KW - Diseases -- Causes & theories of causation
KW - Cold (Disease)
KW - Pain
KW - World War, 1914-1918
N1 - Accession Number: 23887608; Atenstaedt, Robert L. 1; Email Address: Robert.Atenstaedt@nphs.wales.nhs.uk; Affiliations: 1: National Public Health Service for Wales and Institute of Medical and Social Care Research, University of Wales, Bangor, UK; Issue Info: Winter2006, Vol. 17 Issue 4, p282; Thesaurus Term: Trench fever; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Cold (Disease); Subject Term: Pain; Subject Term: World War, 1914-1918; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2006-23635-001
AN - 2006-23635-001
AU - Mills, Carrie
AU - Stephan, Sharon Hoover
AU - Moore, Elizabeth
AU - Weist, Mark D.
AU - Daly, Brian P.
AU - Edwards, Michele
T1 - The President's New Freedom Commission: Capitalizing on opportunities to advance school-based mental health services.
JF - Clinical Child and Family Psychology Review
JO - Clinical Child and Family Psychology Review
JA - Clin Child Fam Psychol Rev
Y1 - 2006/12//
VL - 9
IS - 3-4
SP - 149
EP - 161
CY - Germany
PB - Springer
SN - 1096-4037
SN - 1573-2827
AD - Stephan, Sharon Hoover, School Mental Health Analysis and Action, Department of Psychiatry, University of Maryland, 737 West Lombard St., 4th Floor, Baltimore, MD, US, 21201
N1 - Accession Number: 2006-23635-001. PMID: 17136448 Partial author list: First Author & Affiliation: Mills, Carrie; Center for School Mental Health Analysis and Action, University of Maryland School of Medicine, Baltimore, MD, US. Release Date: 20070430. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; School Based Intervention. Classification: Educational/Vocational Counseling & Student Services (3580). Population: Human (10). Location: US. References Available: Y. Page Count: 13. Issue Publication Date: Dec, 2006.
AB - The report from President George W. Bush's New Freedom Commission on Mental Health (NFC), Achieving the Promise: Transforming Mental Health Care in America (2003), proposes goals and recommendations for improving mental health services. This report has significant implications for the delivery of mental health services through the schools. A focused discussion of the potential opportunities and challenges of implementing NFC recommendations related to school-based mental health is presented. Strategies for addressing five key areas at the intersection of school mental health and the Commission's recommendations include: stigma reduction, suicide prevention, expansion and improvement of school mental health, and screening and treatment of co-occurring mental health and substance abuse disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - New Freedom Commission
KW - school mental health services
KW - 2006
KW - Mental Health Services
KW - School Based Intervention
KW - 2006
U1 - Sponsor: US Department of Health and Human Services, Maternal and Child Health Bureau, Health Resources and Service Administration; Office of Adolescent Health, US. Grant: U93 MC 00174. Other Details: Title V, Social Security Act. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Recipients: No recipient indicated
DO - 10.1007/s10567-006-0003-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23635-001&site=ehost-live&scope=site
UR - sstephan@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00857-003
AN - 2007-00857-003
AU - Carroll, Christopher D.
AU - Manderscheid, Ronald W.
AU - Daniels, Allen S.
AU - Compagni, Amelia
T1 - Convergence of Service, Policy, and Science Toward Consumer-Driven Mental Health Care.
JF - Journal of Mental Health Policy and Economics
JO - Journal of Mental Health Policy and Economics
JA - J Ment Health Policy Econ
Y1 - 2006/12//
VL - 9
IS - 4
SP - 185
EP - 192
CY - Italy
PB - ICMPE
SN - 1091-4358
SN - 1099-176X
AD - Carroll, Christopher D., 1 Choke Cherry Road, Room 6-1059, Rockville, MD, US, 20850
N1 - Accession Number: 2007-00857-003. PMID: 17200595 Partial author list: First Author & Affiliation: Carroll, Christopher D.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Washington, DC, US. Release Date: 20070129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Attitudes; Consumer Satisfaction; Health Care Delivery; Health Care Services; Mental Health Services. Classification: Health & Mental Health Services (3370); Consumer Attitudes & Behavior (3920). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2006.
AB - Background: A common theme is emerging in sentinel reports on the United States health care system. Consumer relevance and demands on service systems and practices are influencing how mental health care is delivered and how systems will be shaped in the future. Aims of the Study: The present report seeks to assemble a confluence of consumer-driven themes from noteworthy reports on the state of the mental health system in the U.S. It also explores innovative efforts, promising practices, collaborative efforts, as well as identification of barriers to consumer-directed care, with possible solutions. Method: The report reviews the relevant public mental health policy and data used in published work. Results: The findings indicate an increasing public and private interest in promoting consumer-driven care, even though historical systems of care predominate, and often create, barriers to widespread redesign of a consumer-centered mental health care system. Innovative consumer-driven practices are increasing as quality, choice, and self-determination become integral parts of a redesigned U.S. mental health care system. Discussion and Limitations: The use of consumer-driven approaches in mental health is limited at best. These programs challenge industry norms and traditional practices. Limitations include the need for additional and thorough evaluations of effectiveness (cost and clinical) and replicability of consumer-directed programs. Implications for Health Care Provision and Use: Consumer-driven services indicate that mental health consumers are expecting to be more participative in their mental health care. This expectation will influence how traditional mental health services and providers become more consumer-centric and meet the demand. Implications for Health Policies: Public and private interest in consumer-driven health care range from creating cost-conscious consumers to individualized control of recovery. The health care sector should seek to invest more resources in the provision of consumer-driven health care programs. The results of this study have implications and are informative for other countries where consumer-directed care is delivered in either the private or public health care systems. Implications for Further Research: More research is needed to obtain further evidence on the use of consumer-driven services and their overall effectiveness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service convergence
KW - mental health care
KW - consumer-directed care
KW - consumer driven solutions
KW - 2006
KW - Consumer Attitudes
KW - Consumer Satisfaction
KW - Health Care Delivery
KW - Health Care Services
KW - Mental Health Services
KW - 2006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00857-003&site=ehost-live&scope=site
UR - Christopher.carroll@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21940-021
AN - 2006-21940-021
AU - Vas, Jorge
AU - Perea-Milla, Emilio
AU - Méndez, Camila
AU - Navarro, Cayetana Sánchez
AU - Rubio, José María León
AU - Brioso, Mauricio
AU - Obrero, Inmaculada García
T1 - Efficacy and safety of acupuncture for chronic uncomplicated neck pain: A randomised controlled study.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2006/12//
VL - 126
IS - 1-3
SP - 245
EP - 255
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Vas, Jorge, Unidad de Tratamiento del Dolor, Centro de Salud Dos Hermanas A, Segovia s/n., 41700, Dos Hermanas, Spain
N1 - Accession Number: 2006-21940-021. PMID: 16934402 Partial author list: First Author & Affiliation: Vas, Jorge; Pain Treatment Unit, Dos Hermanas 'A' Primary Healthcare Centre, Dos Hermanas, Spain. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20070226. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Acupuncture; Chronic Pain; Electrical Stimulation; Neck (Anatomy); Pain Perception. Minor Descriptor: Treatment Effectiveness Evaluation. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Specialized Interventions (3350). Population: Human (10); Male (30); Female (40). Location: Spain. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Northwick Park Neck Pain Questionnaire; Treatment Credibility Scale; SF-36 Health Survey; Visual Analogue Scale. Methodology: Empirical Study; Followup Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2006.
AB - Chronic neck pain is highly prevalent. To determine the efficacy and safety of acupuncture, in comparison with transcutaneous nerve stimulation-placebo (TENS-placebo) in the treatment of chronic uncomplicated neck pain, a single blind prospective study was designed, to be carried out at a Primary Healthcare Centre, with random assignment to two parallel groups and with evaluation and analysis by independent evaluators. A random assignment was made from 123 patients of the 149 initially recruited. These patients had been diagnosed with uncomplicated neck pain and experienced neck motion-related pain intensity equal to or exceeding 30 on a visual analogue scale (VAS) from 0 to 100 mm. The treatment with acupuncture was compared with TENS-placebo, applied over 5 sessions in three weeks. The primary endpoint was the change in maximum pain intensity related to motion of the neck, one week after the final treatment. Sensitivity was analysed per protocol (PP) and variant analyses were by intention to treat (ITT). Adjustment was made for confounders by multiple linear regression, including baseline values and rescue therapy. By ITT analysis, the change in the pain-VAS variable was greater among the experimental group (28.1 (95% CI 21.4-34.7)). The improvements in quality of life (physical aspect), active neck mobility and reduced rescue medication were clinically and statistically significant. In the treatment of the intensity of chronic neck pain, acupuncture is more effective than the placebo treatment and presents a safety profile making it suitable for routine use in clinical practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - acupuncture
KW - transcutaneous nerve stimulation
KW - chronic neck pain
KW - 2006
KW - Acupuncture
KW - Chronic Pain
KW - Electrical Stimulation
KW - Neck (Anatomy)
KW - Pain Perception
KW - Treatment Effectiveness Evaluation
KW - 2006
DO - 10.1016/j.pain.2006.07.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21940-021&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-1326-856X
UR - jvas@acmas.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16600-001
AN - 2007-16600-001
AU - Geller, Jeffrey L.
AU - Biebel, Kathleen
T1 - The premature demise of public child and adolescent inpatient psychiatric beds-- Part II: Challenges and implications.
JF - Psychiatric Quarterly
JO - Psychiatric Quarterly
JA - Psychiatr Q
Y1 - 2006/12//
VL - 77
IS - 4
SP - 273
EP - 291
CY - Germany
PB - Springer
SN - 0033-2720
SN - 1573-6709
AD - Geller, Jeffrey L., Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2007-16600-001. PMID: 16927166 Partial author list: First Author & Affiliation: Geller, Jeffrey L.; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Disturbances; Intensive Care; Pediatrics; Psychiatric Patients; Psychiatric Units. Classification: Inpatient & Hospital Services (3379). Population: Human (10). References Available: Y. Page Count: 19. Issue Publication Date: Dec, 2006.
AB - Psychiatric disorders are the leading reason for hospitalization among 5-19 year olds. Current data, however, suggest there are fewer than necessary available services for children and adolescents requiring intensive, inpatient psychiatric care. Children and adolescents with behavioral health problems, the majority of whom do not receive appropriate treatment, have increased risk of school failure, family disruption, out-of-home placements, poor employment opportunities, and poverty in adulthood. This paper will examine the challenges inherent in serving children and adolescents with serious emotional disturbances, avenues of financing for treatment and services, and various loci of intervention for high-risk children, including inpatient settings and systems of care. The goals of this paper are to illustrate the complexities of working with children and adolescents most in need of intensive psychiatric services, to explore how inpatient services 'fit' into existing treatment approaches, and to discuss the efficacy of downsizing or closing inpatient psychiatric units for this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children
KW - adolescents
KW - intensive care
KW - inpatient psychiatric care
KW - emotional disturbances
KW - 2006
KW - Emotional Disturbances
KW - Intensive Care
KW - Pediatrics
KW - Psychiatric Patients
KW - Psychiatric Units
KW - 2006
DO - 10.1007/s11126-006-9013-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16600-001&site=ehost-live&scope=site
UR - Jeffrey.Geller@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21161-016
AN - 2006-21161-016
AU - Mark, Tami L.
AU - Vandivort-Warren, Rita
AU - Montejano, Leslie B.
T1 - Factors affecting detoxification readmission: Analysis of public sector data from three states.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2006/12//
VL - 31
IS - 4
SP - 439
EP - 445
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Mark, Tami L., Thomson Medstat, Suite 330, 4301 Connecticut Avenue, NW, Washington, DC, US, 20008
N1 - Accession Number: 2006-21161-016. PMID: 17084799 Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Medstat, Washington, DC, US. Release Date: 20061127. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: American Public Health Association Meeting, 2004, Washington, DC, US. Conference Note: This article was presented at the aforementioned conference. Major Descriptor: Detoxification; Drug Rehabilitation; Medicaid; Mental Health; Public Sector. Minor Descriptor: Drug Abuse; Psychiatric Hospital Readmission. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2006.
AB - The objective of this study was to understand the rate of detoxification readmissions and the factors associated with readmission within a public sector population. The study sample was drawn from an integrated database that includes Medicaid and state mental health and substance abuse agency data from three states (Delaware, Oklahoma, and Washington) for 1996-1998. Clients with at least one state agency-sponsored detoxification event in 1996 or 1997 were included in the study. Twenty-seven percent of the sample was readmitted for detoxification within 1 year of their index detoxification. Clients who received two or more substance-abuse-related services within 30 days of their index detoxification were less likely to be readmitted and had a longer time until their second detoxification admission. Detoxification readmission is common in the public sector. Engaging patients in treatment following detoxification may reduce readmission rates and time to readmission. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - detoxification readmission
KW - public sector
KW - states
KW - medicaid
KW - mental health
KW - substance abuse
KW - 2006
KW - Detoxification
KW - Drug Rehabilitation
KW - Medicaid
KW - Mental Health
KW - Public Sector
KW - Drug Abuse
KW - Psychiatric Hospital Readmission
KW - 2006
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1016/j.jsat.2006.05.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21161-016&site=ehost-live&scope=site
UR - tami.mark@thomson.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21844-018
AN - 2006-21844-018
AU - Kuntsche, Emmanuel
AU - Pickett, William
AU - Overpeck, Mary
AU - Craig, Wendy
AU - Boyce, William
AU - de Matos, Margarida Gaspar
T1 - Television Viewing and Forms of Bullying among Adolescents from Eight Countries.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2006/12//
VL - 39
IS - 6
SP - 908
EP - 915
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Kuntsche, Emmanuel, Research Department, Swiss Institute for the Prevention of Alcohol and Drug Problems, PO Box 870, 1001, Lausanne, Switzerland
N1 - Accession Number: 2006-21844-018. PMID: 17116523 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Kuntsche, Emmanuel; Research Department, Swiss Institute for the Prevention of Alcohol and Drug Problems, Lausanne, Switzerland. Release Date: 20070116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Kuntsche, Emmanuel. Major Descriptor: Adolescent Attitudes; Cross Cultural Differences; Television Viewing; Bullying. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: Canada; Estonia; Israel; Latvia; Macedonia; Poland; Portugal; US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Olweus Bully/Victim Questionnaire--Revised. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2006.
AB - Purpose: Based on theories suggesting that frequent television viewers act and react in hostile, malicious, malevolent, or verbally aggressive ways rather than being physically violent, the present study investigates relationships between television viewing and different forms of bullying. Methods: Multilevel regression models were estimated based on cross-sectional data from 31,177 adolescents aged 11, 13, and 15 years from Canada, Estonia, Israel, Latvia, Macedonia, Poland, Portugal, and the United States who participated in the 2001-2002 Health Behavior in School-aged Children Survey. Results: Although all different forms of bullying were associated with television viewing in bivariate analyses, only the verbal forms (i.e. 'calling mean names' and 'spreading rumors') remained significant in multiple regression models. These relationships were observed consistently in all eight participating countries. However, the association between television viewing and physical forms of bullying such as kicking, pushing, or shoving around, varied across countries. In most weekend TV viewing cultures, frequent television viewers were prone to kick or push another student in addition to verbal forms of bullying, which was not the case in weekday viewing cultures. Conclusions: These results demonstrate the importance of limiting adolescents' time engaged in unsupervised television watching, and the need to motivate adolescents to engage in joint family activities or organized after-school activities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - television viewing
KW - bullying
KW - adolescents
KW - cross cultural differences
KW - 2006
KW - Adolescent Attitudes
KW - Cross Cultural Differences
KW - Television Viewing
KW - Bullying
KW - 2006
U1 - Sponsor: SIPA. Recipients: Kuntsche, Emmanuel
U1 - Sponsor: Swiss Federal Office of Public Health, Switzerland. Grant: 00.000300. Recipients: No recipient indicated
DO - 10.1016/j.jadohealth.2006.06.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21844-018&site=ehost-live&scope=site
UR - ekuntsche@sfa-ispa.ch
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23229-016
AN - 2006-23229-016
AU - Mofidi, Mahyar
AU - DeVellis, Robert F.
AU - Blazer, Dan G.
AU - DeVellis, Brenda M.
AU - Panter, A. T.
AU - Jordan, Joanne M.
T1 - Spirituality and Depressive Symptoms in a Racially Diverse US Sample of Community-Dwelling Adults.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 2006/12//
VL - 194
IS - 12
SP - 975
EP - 977
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - DeVellis, Brenda M., University of North Carolina, 309 Rosenau Hall, CB# 7440, Chapel Hill, NC, US, 27599-7440
N1 - Accession Number: 2006-23229-016. PMID: 17164640 Partial author list: First Author & Affiliation: Mofidi, Mahyar; Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20070116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: DeVellis, Brenda M. Major Descriptor: Goodness of Fit; Major Depression; Mental Health; Racial and Ethnic Differences; Spirituality. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Daily Spiritual Experiences Scale; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Dec, 2006.
AB - The role of spirituality in depression is understudied. We examined the relationship between one dimension of spirituality, spiritual experiences, and depressive symptoms, and evaluated whether differences in gender, race, age, and stress moderated the relationship. The study was conducted with a community-based sample of 630 racially diverse middle-aged and older adults. Structural equation modeling was used to estimate a model linking spiritual experiences to depressive symptoms while controlling for demographic and health variables. Spiritual experiences were operationalized using six items of the Daily Spiritual Experiences Scale. Sample items included, 'I feel God's presence,' and, 'I feel comfort in my religion or spirituality.' The model achieved satisfactory goodness of fit. Spiritual experiences were significantly associated with fewer depressive symptoms, and age as well as stress moderated the association, but not gender and race. Spirituality appears to be a psychosocial resource against depressive symptoms, although the results must be confirmed in longitudinal investigations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - spirituality
KW - depressive symptoms
KW - racial diversity
KW - community-dwelling adults
KW - goodness of fit
KW - mental health
KW - 2006
KW - Goodness of Fit
KW - Major Depression
KW - Mental Health
KW - Racial and Ethnic Differences
KW - Spirituality
KW - 2006
U1 - Sponsor: National Institute of Mental Health. Grant: RO1 MH64034-02. Recipients: DeVellis, Brenda M.
U1 - Sponsor: Centers for Disease Control and Prevention/Association of Schools of Public Health. Grant: S043; SI734; S3486. Recipients: Jordan, Joanne M.
U1 - Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Multipurpose Arthritis and Musculoskeletal Disease Center. Grant: 5-P60-AR30701. Recipients: Jordan, Joanne M.
DO - 10.1097/01.nmd.0000243825.14449.de
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23229-016&site=ehost-live&scope=site
UR - Bdevelli@email.unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00245-003
AN - 2007-00245-003
AU - Correa-de-Araujo, Rosaly
T1 - Serious Gaps: How the Lack of Sex/Gender-Based Research Impairs Health.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2006/12//
VL - 15
IS - 10
SP - 1116
EP - 1122
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Correa-de-Araujo, Rosaly, Office of the Americas, Office of the Secretary, Office of Global Health Affairs, Department of Health and Human Services, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2007-00245-003. PMID: 17199452 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Correa-de-Araujo, Rosaly; Office of the Americas, Office of the Secretary, Office of Global Health Affairs, Department of Health and Human Services (HHS), Washington, DC, US. Release Date: 20070430. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Human Sex Differences; Quality of Care; Treatment Outcomes; Health Personnel. Minor Descriptor: Experimentation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2006.
AB - Now is the time to make the sex/gender-based approach routine in our clinical practices, academic environments, and research activities. Sex/gender-based research has the potential to provide evidence for responsive, sensitive, and scientifically sound decision making for women and men. Sex/gender-based research provides the opportunity to design specific interventions to improve mortality, morbidity, and therapeutic outcomes for all. Sex/gender-based research provides the opportunity to detect, understand, and eliminate gender disparities in health care. Findings from sex/gender-based research coupled with clinical experience will allow the development of the most cost-effective models of care to meet the specific needs of women and men. Findings from sex/gender-based research will support policymakers in redesigning the healthcare system through the development of well-targeted policies. Findings from sex/gender-based research, when used to educate medical, pharmacy, and nursing students, residents, and other healthcare professionals in training, will give them the knowledge and tools needed to deliver the best quality of care to all. Findings from sex/gender based research, if properly disseminated, will empower women and men and help them make better choices for their own health care and the care of their loved ones. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex/gender based research
KW - health care system
KW - therapeutic outcomes
KW - healthcare professionals
KW - quality of care
KW - 2006
KW - Health Care Services
KW - Human Sex Differences
KW - Quality of Care
KW - Treatment Outcomes
KW - Health Personnel
KW - Experimentation
KW - 2006
DO - 10.1089/jwh.2006.15.1116
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00245-003&site=ehost-live&scope=site
UR - rosaly.correa@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-20934-005
AN - 2006-20934-005
AU - Turner, Barbara J.
AU - Fleishman, John A.
T1 - Effect of Dysthymia on Receipt of HAART by Minority HIV-infected Women.
JF - Journal of General Internal Medicine
JO - Journal of General Internal Medicine
JA - J Gen Intern Med
Y1 - 2006/12//
VL - 21
IS - 12
SP - 1235
EP - 1241
CY - United Kingdom
PB - Blackwell Publishing
SN - 0884-8734
SN - 1525-1497
AD - Turner, Barbara J., University of Pennsylvania, 1123 Blockley Hall/6021, 423 Guardian Drive, Philadelphia, PA, US, 19104
N1 - Accession Number: 2006-20934-005. PMID: 17105522 Partial author list: First Author & Affiliation: Turner, Barbara J.; Division of General Internal Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, US. Other Publishers: Springer. Release Date: 20070226. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the Society of General Internal Medicine (SGIM), May, 2004, Chicago, IL, US. Grant Information: Shapiro, M.F. Conference Note: This work was presented at the aforementioned conference. Major Descriptor: Drug Therapy; Dysthymic Disorder; HIV; Human Females; Minority Groups. Minor Descriptor: Major Depression; Racial and Ethnic Differences. Classification: Psychological & Physical Disorders (3200); Clinical Psychopharmacology (3340). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2006.
AB - Background: Receipt of highly active antiretroviral therapy (HAART) differs by gender and racial/ethnic group and may reflect an effect of mood disorders. Objective: We examined the effects of dysthymia and major depression on HAART use by 6 groups defined by gender and race/ethnicity (white, black, Hispanic). Main Outcome Measure: Self-reported HAART use in the past 6 months. Data Source: Interview data from the HIV Cost and Services Utilization Study (HCSUS). Independent variables measured in or before the first half of 1997, and HAART use measured in the second half of 1997. Analyses: Multivariate logistic regression of depression and dysthymia on HAART use by 6 patient groups. Participants: One thousand nine hundred and eighty-two HIV-infected adults in HIV care in 1996 and with a CD4 count <500 in 1997. Results: Highly active antiretroviral therapy receipt was the highest for white men (68.6%) and the lowest for Hispanic women (52.7%) and black women (55.4%). Dysthymia was more prevalent in women (Hispanic, 46%; black, 27%; white, 31%) than men (Hispanic, 23%; black, 18%; white, 15%). The prevalence of major depression was greater in whites (women, 35%; men, 31%) than minorities (women, 26%; men, 21%). Compared with white men without dysthymia, the adjusted odds ratios (AORs) of HAART were significantly lower for black women (0.50 [95% confidence interval [95% CI] 0.29 to 0.87]) and Hispanic women (0.45 [95% CI 0.25, 0.79]). Among patients with depression and no dysthymia, minority women had HAART use (AOR = 1.28 [95% CI 0.48 to 3.43]) similar to white men. Limitations: Self-report data from the early era of HAART use; causation cannot be proven; mental health diagnoses may not meet full DSM IV criteria. Conclusions: Dysthymia is highly prevalent in minority women and associated with a 50% reduction in the odds of receiving HAART. This underrecognized condition may contribute more than depression to the 'gender disparity' in HAART use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dysthymia
KW - highly active antiretroviral therapy
KW - minority HIV-infected women
KW - major depression
KW - gender
KW - race
KW - ethnicity
KW - 2006
KW - Drug Therapy
KW - Dysthymic Disorder
KW - HIV
KW - Human Females
KW - Minority Groups
KW - Major Depression
KW - Racial and Ethnic Differences
KW - 2006
U1 - Sponsor: RAND/Agency for Healthcare Research and Quality. Grant: Cooperative agreement HS08578. Other Details: HCSUS. Recipients: Shapiro, M.F. (Prin Inv); Bozzette, S.A. (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1111/j.1525-1497.2006.00597.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20934-005&site=ehost-live&scope=site
UR - bturner@mail.med.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22742-010
AN - 2006-22742-010
AU - Drabant, Emily M.
AU - Hariri, Ahmad R.
AU - Meyer-Lindenberg, Andreas
AU - Munoz, Karen E.
AU - Mattay, Venkata S.
AU - Kolachana, Bhaskar S.
AU - Egan, Michael F.
AU - Weinberger, Daniel R.
T1 - Catechol O-methyltransferase Val¹⁵⁸Met Genotype and Neural Mechanisms Related to Affective Arousal and Regulation.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 2006/12//
VL - 63
IS - 12
SP - 1396
EP - 1406
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
AD - Weinberger, Daniel R., Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Room 4S-235, Bethesda, MD, US, 20892
N1 - Accession Number: 2006-22742-010. PMID: 17146014 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Drabant, Emily M.; National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20061226. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Genotypes; Nervous System; Physiological Arousal; Polymorphism; Sensation Seeking. Minor Descriptor: Short Term Memory. Classification: Psychopharmacology (2580). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Tridimensional Personality Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2006.
AB - Context: Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val¹⁵⁸met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation. Objectives: To examine COMT val¹⁵⁸met effects on corticolimbic circuitry reactivity and functional connectivity during processing of biologically salient stimuli, as well as the relationship to the temperamental trait of novelty seeking. Design: Within-subject functional magnetic resonance imaging study. Setting: National Institute of Mental Health, Genes, Cognition, and Psychosis Program, Bethesda, Md. Patients: One hundred one healthy subjects of both sexes. Results: We found that the met allele was associated with a dose-dependent increase in hippocampal formation and ventrolateral prefrontal cortex activation during viewing of faces displaying negative emotion. In met/met homozygotes, limbic and prefrontal regions showed increased functional coupling. Moreover, in these same subjects, the magnitude of amygdala-orbitofrontal coupling was inversely correlated with novelty seeking, an index of temperamental inflexibility. Conclusions: Our results indicate that heritable variation in dopamine neurotransmission associated with the met allele of the COMT polymorphism results in heightened reactivity and connectivity in corticolimbic circuits. This may reflect a genetic predisposition for inflexible processing of affective stimuli, a mechanism possibly accounting for aspects of arousal and behavioral control that contribute to emotional dysregulation previously reported in met/met individuals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - catechol O-methyltransferase
KW - genotypes
KW - neural mechanisms
KW - affective arousal
KW - regulation
KW - corticolimbic circuitry reactivity
KW - polymorphism
KW - working memory
KW - 2006
KW - Genotypes
KW - Nervous System
KW - Physiological Arousal
KW - Polymorphism
KW - Sensation Seeking
KW - Short Term Memory
KW - 2006
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program. Recipients: No recipient indicated
DO - 10.1001/archpsyc.63.12.1396
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22742-010&site=ehost-live&scope=site
UR - ORCID: 0000-0001-5619-1123
UR -
UR - weinberd@intra.nimh.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06742-001
AN - 2007-06742-001
AU - Ryan, Doreen Major
AU - Bonnett, Doreen M.
AU - Gass, Callie B.
T1 - Sobering thoughts: Town hall meetings on fetal alcohol spectrum disorders.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2006/12//
VL - 96
IS - 12
SP - 2098
EP - 2101
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 2007-06742-001. PMID: 17077397 Partial author list: First Author & Affiliation: Ryan, Doreen Major; Fetal Alcohol Spectrum Disorders (FASD) Center for Excellence, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, US. Release Date: 20070910. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Fetal Alcohol Syndrome; Health Education. Minor Descriptor: Developmental Disabilities; Prenatal Exposure; Towns. Classification: Promotion & Maintenance of Health & Wellness (3365); Substance Abuse & Addiction (3233). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: Dec, 2006.
AB - [Correction Notice: An erratum for this article was reported in Vol 97(3) of American Journal of Public Health (see record [rid]2007-07387-001[/rid]). An image title and source were improperly reported. On page 2100, the image title is Tahitian Flower. On page 2100, the image source line is: Source, http://www.sereneartistry.com. doi:10.2105/AJPH.2005.062729e] Prenatal exposure to alcohol is one of the leading causes of preventable birth defects and developmental disabilities. During the past 30 years, fetal alcohol spectrum disorders (FASD), including fetal alcohol syndrome, have gradually begun to attract attention. However, awareness and understanding of the disorders remain low, and people who are affected are seriously underserved. The FASD Center for Excellence held a series of town hall meetings in 2002 and 2003 to gauge the issues surrounding FASD nationwide. On the basis of its findings, the center proposed a series of recommendations to begin to remedy some of the deficiencies that were identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal alcohol spectrum disorders
KW - prenatal exposure
KW - town hall meetings
KW - 2006
KW - Fetal Alcohol Syndrome
KW - Health Education
KW - Developmental Disabilities
KW - Prenatal Exposure
KW - Towns
KW - 2006
U1 - Sponsor: Northrop Grumman Information Technology. Grant: 277-01-6068. Other Details: FASD Center for Excellence. Recipients: No recipient indicated
DO - 10.2105/AJPH.2005.062729
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06742-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23093-002
AN - 2006-23093-002
AU - Banthin, Jessica S.
AU - Bernard, Didem M.
T1 - Changes in financial burdens for health care: National estimates for the population younger than 65 years, 1996 to 2003.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2006/12//
VL - 296
IS - 22
SP - 2712
EP - 2719
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
AD - Banthin, Jessica S., Division of Modeling Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2006-23093-002. PMID: 17164457 Partial author list: First Author & Affiliation: Banthin, Jessica S.; Division of Modeling Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20070212. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Banthin, Jessica S. Major Descriptor: Health Care Costs; Health Care Services; Income Level; Trends. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2006.
AB - Context: Policymakers as well as physicians need to understand how rapidly rising health care costs are affecting specific groups of patients. Objective: To estimate the number and characteristics of individuals in the United States faced with very high financial burdens for health care. Design, Setting, and Population: Data from a nationally representative sample of civilian, noninstitutionalized US individuals younger than 65 years from the Medical Expenditure Panel Surveys were used to calculate 2 measures of financial burden as a function of tax-adjusted family income. Total burden included all out-of-pocket expenditures for health care services, including premiums. Health care services burden excluded premiums and, when applied to the insured population, was used to identify the underinsured. We defined the underinsured as insured persons with health care service burdens in excess of 10% of tax-adjusted family income. Main Outcome Measures: Total and health care services burdens exceeding 10% and 20% of family income in 1996 and 2003. Results: In 2003, there were 48.8 million individuals (19.2%) living in families spending more than 10% of family income on health care, an increase of 11.7 million persons since 1996. Of these individuals, about 18.7 million (7.3%) were spending more than 20% of family income. In 2003, individuals with higher-than-average risk of incurring high total burdens included poor and low-income persons and those with non-group coverage, aged 55 to 64 years, living in a non-metropolitan statistical area, in fair or poor health, having any type of limitation, or having a chronic medical condition. Applying our definition of underinsured to the insured population, an estimated 17.1 million persons younger than 65 years were underinsured in 2003, including 9.3 million persons with private employment-related insurance, 1.3 million persons with private non-group policies, and 6.6 million persons with public coverage. Conclusions: Our analysis identifies patients at greatest risk of health-related financial burdens that may adversely affect their access and adherence to recommended treatments. Our study also highlights the high costs associated with non-group health insurance policies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - financial burdens
KW - health care services
KW - health care costs
KW - trends
KW - income level
KW - age differences
KW - 2006
KW - Health Care Costs
KW - Health Care Services
KW - Income Level
KW - Trends
KW - 2006
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: Banthin, Jessica S.; Bernard, Didem M.
DO - 10.1001/jama.296.22.2712
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23093-002&site=ehost-live&scope=site
UR - Jessica.Banthin@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-20505-004
AN - 2006-20505-004
AU - Siahpush, Mohammad
AU - Borland, Ron
AU - Taylor, Janet
AU - Singh, Gopal K.
AU - Ansari, Zahid
AU - Serraglio, Adrian
T1 - The association of smoking with perception of income inequality, relative material well-being, and social capital.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2006/12//
VL - 63
IS - 11
SP - 2801
EP - 2812
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Siahpush, Mohammad, Cancer Council Victoria, Centre for Behavioural Research in Cancer, 100 Drummond Street, Carlton, Melbourne, VIC, Australia, 3053
N1 - Accession Number: 2006-20505-004. PMID: 16971030 Partial author list: First Author & Affiliation: Siahpush, Mohammad; Cancer Council Victoria, Centre for Behavioural Research in Cancer, Melbourne, VIC, Australia. Release Date: 20070430. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adult Attitudes; Income Level; Social Capital; Socioeconomic Status; Tobacco Smoking. Minor Descriptor: Deprivation; Well Being. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Dec, 2006.
AB - The aim of this study is to examine the association of smoking status with income inequality, relative deprivation, perception of relative material well-being and community-level social capital, controlling for individual-level indicators of social capital, and common socio-economic variables. Data were from telephone interviews of approximately 126 residents selected at random (using the Electronic White Pages) from each of 22 local government areas (LGAs) in the Melbourne metropolitan region, Victoria, Australia (total n=2762). We used logistic regression to assess the association of covariates with smoking status. Being a smoker was associated with a higher level of perceived income inequality, lower perception of relative material well-being and living in a community with a lower degree of trust and safety. While the cross-sectional design of the study does not allow causal inferences, the results imply that smoking is less prevalent in communities that are more egalitarian and have a higher stock of social capital. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking
KW - perceived income inequality
KW - well-being
KW - social capital
KW - socio-economic variables
KW - relative deprivation
KW - 2006
KW - Adult Attitudes
KW - Income Level
KW - Social Capital
KW - Socioeconomic Status
KW - Tobacco Smoking
KW - Deprivation
KW - Well Being
KW - 2006
U1 - Sponsor: Victorian Health Promotion Foundation (VicHealth), Australia. Recipients: No recipient indicated
U1 - Sponsor: Department of Human Services, Australia. Recipients: No recipient indicated
DO - 10.1016/j.socscimed.2006.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20505-004&site=ehost-live&scope=site
UR - adrian.serraglio@dhs.vic.gov.au
UR - zahid.ansari@dhs.vic.gov.au
UR - gsingh@hrsa.gov
UR - jtaylor@bsl.org.au
UR - Ron.Borland@cancervic.org.au
UR - mohammad.siahpush@cancervic.org.au
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Dagang Wu
AU - Shamsi, Saad
AU - Ji Chen
AU - Kainz, Wolfgang
T1 - Evaluations of Specific Absorption Rate and Temperature Increase Within Pregnant Female Models in Magnetic Resonance Imaging Birdcage Coils.
JO - IEEE Transactions on Microwave Theory & Techniques
JF - IEEE Transactions on Microwave Theory & Techniques
Y1 - 2006/12/02/Dec2006 Part 2 Of 2
VL - 54
M3 - Article
SP - 4472
EP - 4478
SN - 00189480
AB - This paper presents a detailed numerical study of specific absorption rate (SAR) and temperature increase calculations within pregnant female models exposed to magnetic resonance imaging (MRI). Nine pregnant female models, representing different pregnant stages, were used for this study. SAR and temperature increase within and around fetuses at different pregnancy stages were calculated for two MRI operating modes (normal mode and first-level controlled mode) at 64 and 128 MHz. Local fetus energy deposition exceeds the International Electrotechnical Commission limit of 10 W/kg in the first-level controlled mode at 64 MHz. Fetus temperature exceeds or approaches 38 °C for both frequencies in the first-level controlled mode at later stages of pregnancy. The core temperature limits for both modes and both frequencies are not exceeded. The results show higher maximum SAR and higher temperature at 64 MHz and during later pregnancy stages with a significant increase starting with the fifth month of pregnancy. Based on the results of this study, radiologists can minimize local fetus heating, especially late in pregnancy, by using normal mode sequences, which minimize the whole body SAR in the mother. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Microwave Theory & Techniques is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIC resonance imaging
KW - PREGNANT women
KW - ELECTROMAGNETIC devices
KW - ELECTROMAGNETIC waves
KW - MEDICAL radiology
KW - Electromagnetic heating
KW - finite-difference method
KW - magnetic resonance imaging (MRI)
KW - pregnant woman
KW - safety standards
KW - safety standards. Electromagnetic heating
KW - INTERNATIONAL Electrotechnical Commission
N1 - Accession Number: 23483489; Dagang Wu 1 Shamsi, Saad 1 Ji Chen 1; Email Address: jchenl8@mail.uh.edu Kainz, Wolfgang 2; Email Address: wolfgang.kainz@fda.hhs.gov; Affiliation: 1: Electrical and Computer Engineering Department, University of Houston, Houston, TX 77204 USA 2: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20852 USA; Source Info: Dec2006 Part 2 Of 2, Vol. 54, p4472; Subject Term: MAGNETIC resonance imaging; Subject Term: PREGNANT women; Subject Term: ELECTROMAGNETIC devices; Subject Term: ELECTROMAGNETIC waves; Subject Term: MEDICAL radiology; Author-Supplied Keyword: Electromagnetic heating; Author-Supplied Keyword: finite-difference method; Author-Supplied Keyword: magnetic resonance imaging (MRI); Author-Supplied Keyword: pregnant woman; Author-Supplied Keyword: safety standards; Author-Supplied Keyword: safety standards. Electromagnetic heating; Company/Entity: INTERNATIONAL Electrotechnical Commission; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 3 Diagrams, 4 Charts, 8 Graphs; Document Type: Article
L3 - 10.1109r1'MTT.2006.884655
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23483489&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cragan, Janet D.
AU - Friedman, J. M.
AU - Holmes, Lewis B.
AU - Uhl, Kathleen
AU - Green, Nancy S.
AU - Riley, Laura
T1 - Ensuring the Safe and Effective Use of Medications During Pregnancy: Planning and Prevention Through Preconception Care.
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
Y1 - 2006/12/02/Dec2006 Supplement
VL - 10
M3 - Article
SP - 129
EP - 135
PB - Springer Science & Business Media B.V.
SN - 10927875
AB - The article discusses the approaches on how to ensure safety and effective applications of medications during pregnancy. The use of medication at the period of pregnancy can be a concern for both women and health care providers. It is said that exposures to medications, alcohol, and other exogenous factors might induce harmful effects on the development of the fetus. Moreover, factors of preconception care which can aid to reduce the possibilities of birth defects are given.
KW - PREGNANT women -- Medical care
KW - PRECONCEPTION care
KW - PRENATAL care
KW - HUMAN abnormalities
KW - PREGNANCY complications
KW - Anticonvulsants
KW - Asthma
KW - Isotretinoin
KW - Medications
KW - Preconception care
KW - Pregnancy
N1 - Accession Number: 22344080; Cragan, Janet D. 1; Email Address: jcragan@cdc.gov Friedman, J. M. 2 Holmes, Lewis B. 3 Uhl, Kathleen 4 Green, Nancy S. 5 Riley, Laura 6; Affiliation: 1: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, MS E-86, 1600 Clifton Road, N.E., Atlanta, GA 30333 2: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada 3: Genetics and Teratology Unit, MassGeneral Hospital for Children, Boston, MA 4: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 5: March of Dimes Birth Defects Foundation, White Plains, NY 6: Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, MA; Source Info: Dec2006 Supplement, Vol. 10, p129; Subject Term: PREGNANT women -- Medical care; Subject Term: PRECONCEPTION care; Subject Term: PRENATAL care; Subject Term: HUMAN abnormalities; Subject Term: PREGNANCY complications; Author-Supplied Keyword: Anticonvulsants; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Isotretinoin; Author-Supplied Keyword: Medications; Author-Supplied Keyword: Preconception care; Author-Supplied Keyword: Pregnancy; Number of Pages: 7p; Document Type: Article
L3 - 10.1007/s10995-006-0102-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=22344080&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Encinosa, William
AU - Hagan, Michael
T1 - Introduction: AHRQ Research on Health Care Markets.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2006/12/02/Dec2006 Supplement
VL - 63
IS - 6S
M3 - Article
SP - 3S
EP - 8S
SN - 10775587
AB - The article discusses various reports published within the issue, including one by Kathryn Phillips, Jennifer Haas, and Su-Ying Liang on measuring managed care using national survey, one by Dennis Scanlon and colleagues on health insurance market competition, and one by Arvind Jain, Jeannette Rogowski, and José Escarce on evidence of mortality after hospitalization.
KW - MANAGED care plans (Medical care)
KW - HOSPITALIZATION insurance
N1 - Accession Number: 55006124; Encinosa, William 1 Hagan, Michael 1; Affiliation: 1: Agency for Healthcare Research and Quality; Source Info: Dec2006 Supplement, Vol. 63 Issue 6S, p3S; Subject Term: MANAGED care plans (Medical care); Subject Term: HOSPITALIZATION insurance; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524114 Direct Health and Medical Insurance Carriers; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 2590
L3 - 10.1177/1077558706293842
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=55006124&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105833463
T1 - Quality and safety by design.
AU - Battles JB
Y1 - 2006/12/02/
N1 - Accession Number: 105833463. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Health Care Delivery -- Administration
KW - Quality of Health Care
KW - Safety
KW - Treatment Errors -- Prevention and Control
KW - Health Care Delivery -- Standards
KW - Medical Practice, Evidence-Based -- Standards
KW - Organizational Culture
KW - Organizational Efficiency
KW - Quality Improvement
KW - Systems Analysis
KW - United States
SP - i1
EP - i3
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - Rather than continuing to try to measure the width and depths of the quality chasm, a legitimate question is how does one actually begin to close the quality chasm? One way to think about the problem is as a design challenge rather than as a quality improvement challenge. It is time to move from reactive measurement to a more proactive use of proven design methods, and to involve a number of professions outside health care so that we can design out system failure and design in quality of care. Is it possible to actually design in quality and design out failure? A three level conceptual framework design would use the six quality aims laid out in Crossing the quality chasm. The first or core level of the framework would be designing for patient centered care, with safety as the second level. The third design attributes would be efficiency, effectiveness, timeliness, and equity. Design methods and approaches are available that can be used for the design of healthcare organizations and facilities, learning systems to train and maintain competency of health professionals, clinical systems, clinical work, and information technology systems. In order to bring about major improvements in quality and safety, these design methods can and should be used to redesign healthcare delivery systems.
SN - 1475-3898
AD - Agency for Healthcare Research and Quality (AHRQ), Center for Quality Improvement and Patient Safety, 540 Gather Road, Rockville, MD 20850, USA. James.Battles@ahrq.hhs.gov.
U2 - PMID: 17142601.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105833463&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105833460
T1 - Improving patient safety by instructional systems design.
AU - Battles JB
Y1 - 2006/12/02/
N1 - Accession Number: 105833460. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Europe; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 101136980.
KW - Education, Medical -- Administration
KW - Quality Assurance
KW - Safety
KW - Teaching
KW - Clinical Competence
KW - Curriculum
KW - Systems Analysis
KW - Treatment Errors -- Prevention and Control
KW - United States
SP - i25
EP - i29
JO - Quality & Safety in Health Care
JF - Quality & Safety in Health Care
JA - QUAL SAF HEALTH CARE
PB - BMJ Publishing Group
AB - Education and training are important elements in patient safety, both as a potential contributing factor to risks and hazards of healthcare associated injury or harm and as an intervention to be used in eliminating or preventing such harm. All too often we have relied on training as the only interventions for patient safety without examining other alternatives or realizing that, in some cases, the training systems themselves are part of the problem. One way to ensure safety by design is to apply established design principles to education and training. Instructional systems design (ISD) is a systematic method of development of education and training programs for improved learner performance. The ISD process involves five integrated steps: analysis, development, design, implementation, and evaluation (ADDIE). The application of ISD using the ADDIE approach can eliminate or prevent education and training from being a contributing factor of health associated injury or harm, and can also be effective in preventing injury or harm.
SN - 1475-3898
AD - Agency for Healthcare Research and Quality (AHRQ), Center for Quality Improvement and Patient Safety, 540 Gather Road, Rockville, MD 20850, USA. jabattles@ahrq.gov.
U2 - PMID: 17142604.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105833460&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Milberger, Sharon
AU - Davis, Ronald M.
AU - Douglas, Clifford E.
AU - Beasley, John K.
AU - Burns, David
AU - Houston, Thomas
AU - Shopland, Donald
T1 - Tobacco manufacturers' defence against plaintiffs' claims of cancer causation: throwing mud at the wall and hoping some of it will stick.
JO - Tobacco Control
JF - Tobacco Control
Y1 - 2006/12/02/Dec2006 Supplement 4
VL - 15
M3 - Article
SP - iv17
EP - iv26
SN - 09644563
AB - Background: In the late 1990s and the early part of this decade, the major US cigarette manufacturers admitted, to varying degrees, that smoking causes cancer and other diseases. Objective: To examine how tobacco manufacturers have defended themselves against charges that their products caused cancer in plaintiffs in 34 personal injury lawsuits, all but one of which were litigated between the years 1986 and 2003. Methods: Defence opening and closing statements, trial testimony, and depositions for these cases were obtained from the Tobacco Deposition and Trial Testimony Archive (http://tobaccodocuments.org/datta/). All available defence-related transcripts from these cases were reviewed and a content analysis was conducted to identify common themes in the defendants' arguments. Results: After review of the transcripts, defendants' arguments were grouped into seven categories: (1) there is no scientific proof that cigarette smoking causes lung cancer; (2) the plaintiff did not have lung cancer as claimed; (3) the plaintiff had a type of lung cancer not associated with cigarette smoking; (4) the plaintiff had cancer that may have been associated with cigarette smoking or smokeless tobacco use, but tobacco products were not to blame in this particular case; (5) the plaintiff had cancer that may have been associated with cigarette smoking, but the defendant's cigarette brands were not to blame; (6) the defendant's cigarettes (or smokeless tobacco) may have played a role in the plaintiff's illness/death, but other risk factors were present that negate or mitigate the defendant's responsibility; and (7) the defendant's cigarettes may have been a factor in the plaintiff's illness/death, but the plaintiff knew of the health risks and exercised free will in choosing to smoke and declining to quit. Use of the argument that smoking is not a proven cause of lung cancer declined in frequency during and after the period when tobacco companies began to publicly admit that smoking causes disease. Corresponding increases occurred over time in the use of other arguments (namely, presence of other risk factors and "free will"). Conclusions: Despite the vast body of literature showing that cigarette smoking causes cancer, and despite tobacco companies' recent admissions that smoking causes cancer, defendants used numerous arguments in these cases to deny that their products had caused cancer in plaintiffs. The cigarette companies, through their public admissions and courtroom arguments, seem to be saying, "Yes, smoking causes lung cancer, but not in people who sue us". [ABSTRACT FROM AUTHOR]
AB - Copyright of Tobacco Control is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEFENSE (Administrative procedure)
KW - CANCER
KW - INDUSTRIALISTS
KW - TOBACCO
KW - SMOKING
KW - RISK
KW - FREE will & determinism
KW - UNITED States
N1 - Accession Number: 23597845; Milberger, Sharon 1; Email Address: smilber1@hfhs.org Davis, Ronald M. 1 Douglas, Clifford E. 2 Beasley, John K. 3 Burns, David 4 Houston, Thomas 5 Shopland, Donald 6; Affiliation: 1: Center for Health Promotion and Disease Prevention, Henry Ford Health System, Detroit, Michigan, USA 2: Tobacco Control Law & Policy Consulting, Ann Arbor, Michigan, USA 3: Center for Tobacco Use Prevention and Research, Michigan Public Health Institute, Okemos, Michigan, USA 4: University of California, San Diego, School of Medicine, San Diego, California, USA 5: OhioHealth Nicotine Dependence Program, Columbus, Ohio, USA 6: Ringold, Georgia, USA, US Public Health Service (retired); Source Info: Dec2006 Supplement 4, Vol. 15, piv17; Subject Term: DEFENSE (Administrative procedure); Subject Term: CANCER; Subject Term: INDUSTRIALISTS; Subject Term: TOBACCO; Subject Term: SMOKING; Subject Term: RISK; Subject Term: FREE will & determinism; Subject Term: UNITED States; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 453991 Tobacco Stores; Number of Pages: 10p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1136/tc.2006.016956
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23597845&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Yi
AU - Miao, Haijun
AU - Lin, Mei
AU - Fan, Guorong
AU - Hong, Zhanying
AU - Wu, Huiling
AU - Wu, Yutian
T1 - Development and validation of a selective and robust LC–MS/MS method for high-throughput quantifying rizatriptan in small plasma samples: Application to a clinical pharmacokinetic study
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2006/12/05/
VL - 844
IS - 2
M3 - Article
SP - 268
EP - 277
SN - 15700232
AB - Abstract: An analytical method based on liquid chromatography with positive ion electrospray ionization (ESI) coupled to tandem mass spectrometry detection (LC–MS/MS) was developed for the determination of a potent 5-HT1B/1D receptor agonist, rizatriptan in human plasma using granisetron as the internal standard. The analyte and internal standard were isolated from 100μL plasma samples by liquid–liquid extraction (LLE) and chromatographed on a Lichrospher C18 column (4.6mm×50mm, 5μm) with a mobile phase consisting of acetonitrile–10mM aqueous ammonium acetate–acetic acid (50:50:0.5, v/v/v) pumped at 1.0mL/min. The method had a chromatographic total run time of 2min. A Varian 1200L electrospray tandem mass spectrometer equipped with an electrospray ionization source was operated in selected reaction monitoring (SRM) mode with the precursor-to-product ion transitions m/z 270→201 (rizatriptan) and 313.4→138 (granisetron) used for quantitation. The assay was validated over the concentration range of 0.05–50ng/mL and was found to have acceptable accuracy, precision, linearity, and selectivity. The mean extraction recovery from spiked plasma samples was above 98%. The intra-day accuracy of the assay was within 12% of nominal and intra-day precision was better than 13% C.V. Following a 10mg dose of the compound administered to human subjects, mean concentrations of rizatriptan ranged from 0.2 to 70.6ng/mL in plasma samples collected up to 24h after dosing. Inter-day accuracy and precision results for quality control samples run over a 5-day period alongside clinical samples showed mean accuracies of within 12% of nominal and precision better than 9.5% C.V. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - CHROMATOGRAPHIC analysis
KW - LIQUID chromatography
KW - ELECTROSPRAY ionization mass spectrometry
KW - ACETONITRILE
KW - 5-HT1B/1D receptor agonist
KW - LC–MS/MS
KW - Pharmacokinetics
KW - Rizatriptan
N1 - Accession Number: 23209123; Chen, Yi 1,2 Miao, Haijun 3 Lin, Mei 4 Fan, Guorong 1,2; Email Address: Guorfan@yahoo.com.cn Hong, Zhanying 1,2 Wu, Huiling 1,2 Wu, Yutian 1,2; Affiliation: 1: Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China 2: Shanghai Key Laboratory for Pharmaceutical Metabolite Research, No. 325 Guohe Road, Shanghai 200433, PR China 3: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China 4: Shanghai Food and Drug Administration, No. 288 South Henan Road, Shanghai 200010, PR China; Source Info: Dec2006, Vol. 844 Issue 2, p268; Subject Term: BLOOD plasma; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: LIQUID chromatography; Subject Term: ELECTROSPRAY ionization mass spectrometry; Subject Term: ACETONITRILE; Author-Supplied Keyword: 5-HT1B/1D receptor agonist; Author-Supplied Keyword: LC–MS/MS; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Rizatriptan; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jchromb.2006.07.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23209123&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Notari, Luigi
AU - Baladron, Victoriano
AU - Aroca-aAguilar, J. Daniel
AU - Balko, Natalia
AU - Heredia, Raul
AU - Meyer, Christina
AU - Notario, Patricia M.
AU - Saravanamuthu, Senthil
AU - Nueda, Maria-Luisa
AU - Sanchez-Sanchez, Francisco
AU - Escribano, Julio
AU - Laborda, Jorge
AU - Becerra, S. Patricia
T1 - Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2006/12/08/
VL - 281
IS - 49
M3 - Article
SP - 38022
EP - 38037
SN - 00219258
AB - Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of retina, retinoblastoma, and CNS cells. This study was designed to reveal a receptor involved in the biological activities of PEDF. Using a yeast two-hybrid screening, we identified a novel gene from pigment epithelium of the human retina that codes for a PEDF-binding partner, which we term PEDF-R. The derived polypeptide has putative transmembrane, intracellular and extracellular regions, and a phospholipase domain. Recently, PEDF-R (TTS-2.2/independent phospholipase A2 (PLA2)ζ and mouse desnutrin/ATGL) has been described in adipose cells as a member of the new calcium-independent PLA2/nutrin/patatin-like phospholipase domain-containing 2 (PNPLA2) family that possesses triglyceride lipase and acylglycerol transacylase activities. Here we describe the PEDF-R gene expression in the retina and its heterologous expression by bacterial and eukaryotic systems, and we demonstrate that its protein product has specific and high binding affinity for PEDF, has a potent phospholipase A2 activity that liberates fatty acids, and is associated with eukaryotic cell membranes. Most importantly, PEDF binding stimulates the enzymatic phospholipase A2 activity of PEDF-R. In conclusion, we have identified a novel PEDF-R gene in the retina for a phospholipase-linked membrane protein with high affinity for PEDF, suggesting a molecular pathway by which ligand/receptor interaction on the cell surface could generate a cellular signal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIUM
KW - PROTEINS
KW - CELL membranes
KW - RETINA
KW - PHOSPHOLIPASES
KW - FAT cells
KW - EUKARYOTIC cells
KW - LIGANDS (Biochemistry)
N1 - Accession Number: 23537435; Notari, Luigi 1 Baladron, Victoriano 2,3 Aroca-aAguilar, J. Daniel 3 Balko, Natalia 1 Heredia, Raul 1 Meyer, Christina 1 Notario, Patricia M. 4 Saravanamuthu, Senthil 1 Nueda, Maria-Luisa 2,3 Sanchez-Sanchez, Francisco 3 Escribano, Julio 3 Laborda, Jorge 3,4 Becerra, S. Patricia 1; Email Address: becerrap@nei.nih.gov; Affiliation: 1: National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 2: Food and Drug Administration, Bethesda, Maryland 20892 3: School of Medicine/Centro Regional de Investigaciones Biomédicas, University of Castilla-La Mancha, Albacete 02071, Spain 4: Georgetown University, Washington, D. C. 20057; Source Info: 12/8/2006, Vol. 281 Issue 49, p38022; Subject Term: EPITHELIUM; Subject Term: PROTEINS; Subject Term: CELL membranes; Subject Term: RETINA; Subject Term: PHOSPHOLIPASES; Subject Term: FAT cells; Subject Term: EUKARYOTIC cells; Subject Term: LIGANDS (Biochemistry); Number of Pages: 16p; Illustrations: 2 Charts, 10 Graphs; Document Type: Article
L3 - 10.1074/jbc.M600353200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106267345
T1 - Changes in financial burdens for health care: national estimates for the population younger than 65 years, 1996 to 2003.
AU - Banthin JS
AU - Bernard DM
AU - Banthin, Jessica S
AU - Bernard, Didem M
Y1 - 2006/12/13/
N1 - Accession Number: 106267345. Language: English. Entry Date: 20070413. Revision Date: 20161112. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality (AHRQ). NLM UID: 7501160.
KW - Economics -- Trends
KW - Health Care Costs -- Trends
KW - Adult
KW - Economic Aspects of Illness
KW - Economics
KW - Female
KW - Funding Source
KW - Health Status
KW - Income
KW - Insurance -- Economics
KW - Insurance, Health -- Economics
KW - Male
KW - Middle Age
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 2712
EP - 2719
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 296
IS - 22
CY - Chicago, Illinois
PB - American Medical Association
AB - Context: Policymakers as well as physicians need to understand how rapidly rising health care costs are affecting specific groups of patients.Objective: To estimate the number and characteristics of individuals in the United States faced with very high financial burdens for health care.Design, Setting, and Population: Data from a nationally representative sample of civilian, noninstitutionalized US individuals younger than 65 years from the Medical Expenditure Panel Surveys were used to calculate 2 measures of financial burden as a function of tax-adjusted family income. Total burden included all out-of-pocket expenditures for health care services, including premiums. Health care services burden excluded premiums and, when applied to the insured population, was used to identify the underinsured. We defined the underinsured as insured persons with health care service burdens in excess of 10% of tax-adjusted family income.Main Outcome Measures: Total and health care services burdens exceeding 10% and 20% of family income in 1996 and 2003.Results: In 2003, there were 48.8 million individuals (19.2%) living in families spending more than 10% of family income on health care, an increase of 11.7 million persons since 1996. Of these individuals, about 18.7 million (7.3%) were spending more than 20% of family income. In 2003, individuals with higher-than-average risk of incurring high total burdens included poor and low-income persons and those with nongroup coverage, aged 55 to 64 years, living in a non-metropolitan statistical area, in fair or poor health, having any type of limitation, or having a chronic medical condition. Applying our definition of underinsured to the insured population, an estimated 17.1 million persons younger than 65 years were underinsured in 2003, including 9.3 million persons with private employment-related insurance, 1.3 million persons with private nongroup policies, and 6.6 million persons with public coverage.Conclusions: Our analysis identifies patients at greatest risk of health-related financial burdens that may adversely affect their access and adherence to recommended treatments. Our study also highlights the high costs associated with nongroup health insurance policies.
SN - 0098-7484
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, Md 20850, USA
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, Md 20850, USA. Jessica.Banthin@ahrq.hhs.gov
U2 - PMID: 17164457.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Binienda, Zbigniew K.
AU - Ali, Syed F.
AU - Virmani, Ashraf
AU - Amato, Antonino
AU - Salem, Nadia
AU - Przybyla, Beata D.
T1 - Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: Neuroprotective role of l-carnitine
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2006/12/13/
VL - 410
IS - 1
M3 - Article
SP - 62
EP - 65
SN - 03043940
AB - Abstract: This study tested the hypothesis that the expression of uncoupling proteins (UCPs) and dopamine (DA) system genes is responsive to 3-nitropropionic acid (3-NPA) neurotoxic effects and to the neuroprotective effects of the mitochondrial enhancer, l-carnitine (LC), in the rat striatum. Inactivation of mitochondrial succinate dehydrogenase (SDH) by 3-NPA results in hypoxic brain damage. Hypoxic conditions induce uncoupling protein-2 (UCP-2). An increase in UCP-2 expression may lead to a decrease in production of reactive oxygen species (ROS) associated with energy depletion. However, this adaptive response can also lead to a reduction of ATP that may further contribute to energy deficit and mitochondrial dysfunction. Here, male adult Sprague–Dawley rats (n =5/group) were injected either with saline or 3-NPA at 30mg/kg, s.c. alone or 30min after pre-treatment with LC (100mg/kg, i.p.). Rectal temperature was monitored before treatment and 4h following 3-NPA administration. Animals were sacrificed 4h post-treatment. Total RNA was isolated from the striatum and transcripts of UCP-2, UCP-4 and UCP-5 genes, as well as genes related to dopamine metabolism, such as DA D1 and D2 receptors, tyrosine hydroxylase (TH), monoamine oxidase-B (MAO-B), and vesicular monoamine transporter-2 (VMAT-2), were measured using real-time reverse transcription polymerase chain reaction (RT-PCR). While core temperature decreased significantly in 3-NPA-treated rats, LC significantly inhibited the hypothermic effect of 3-NPA (p <0.05). 3-NPA caused a significant increase in UCP-2 and DA D1 receptor gene expression in the striatum and both effects were attenuated by pre-treatment with LC. Since LC maintains the ATP/ADP ratio and was previously shown to be neuroprotective against 3-NPA toxicity, the modulation of UCP-2 expression by LC suggests that LC counteracts energy dissipation and thus prevents the negative effects of ATP decline on DA neurotransmission. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTRANSMITTERS
KW - CEREBROVASCULAR disease
KW - BRAIN -- Wounds & injuries
KW - BRAIN damage
KW - 3-Nitropropionic acid
KW - Dopamine
KW - l-Carnitine
KW - Rat
KW - Striatum
KW - Uncoupling proteins
N1 - Accession Number: 22965639; Binienda, Zbigniew K. 1; Email Address: zbigniew.binienda@fda.hhs.gov Ali, Syed F. 1 Virmani, Ashraf 2 Amato, Antonino 3 Salem, Nadia 3 Przybyla, Beata D. 1,4; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 2: Research and Development, Sigma-Tau HealthScience, S.p.A., Pomezia, Rome, Italy 3: Sigma-Tau Research Inc., Gaithersburg, MD 20877, USA 4: Institute of Aging, UAMS, Little Rock, AR 72205, USA; Source Info: Dec2006, Vol. 410 Issue 1, p62; Subject Term: NEUROTRANSMITTERS; Subject Term: CEREBROVASCULAR disease; Subject Term: BRAIN -- Wounds & injuries; Subject Term: BRAIN damage; Author-Supplied Keyword: 3-Nitropropionic acid; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: l-Carnitine; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Striatum; Author-Supplied Keyword: Uncoupling proteins; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neulet.2006.09.070
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Richard J.
AU - Tepper, Shirley
AU - Kammouni, Wafa
AU - Anderson, Lucy M.
AU - Kritchevsky, David
T1 - Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung—–Importance of mouse strain
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2006/12/15/
VL - 72
IS - 12
M3 - Article
SP - 1749
EP - 1755
SN - 00062952
AB - Abstract: Our previous work established that hypocholesterolemic agents altered K-ras intracellular localization in lung. Here, we examined K-ras activity to define further its potential importance in lung carcinogenesis. K-ras activity in lungs from male A/J, Swiss and C57BL/6 mice was examined. For 3 weeks, mice consumed either 2 or 4% cholestyramine (CS), 1% niacin, 5% konjac mannan (KM), or were injected with lovastatin 25mg/kg three or five times weekly (Lov-3X and Lov-5X). A pair-fed (PF) group was fed the same quantity of diet consumed by the Lov-5X mice to control for lower body weights in Lov-5X mice. After 3 weeks, serum cholesterol was assayed with a commercial kit. Activated K-ras protein from lung was affinity precipitated with a Raf-1 ras binding domain-glutathione-S-transferase fusion protein bound to glutathione-agarose beads, followed by Western blotting, K-ras antibody treatment, and chemiluminescent detection. Only KM reduced serum cholesterol (in two of three mouse strains). In C56BL/6 mice treated with Lov-3X, lung K-ras activity increased 1.8-fold versus control (p =0.009). In normal lung with wild-type K-ras, this would be expected to be associated with maintenance of differentiation. In A/J mice fed 4% CS, K-ras activity increased 2.1-fold (p =0.02), which might be responsible for the reported enhancement of carcinogenesis in carcinogen-treated rats fed CS. KM feeding and PF treatment had no significant effects on K-ras activity. These data are consistent with the concept that K-ras in lung has an oncogenic function when mutated, but may act as a tumor suppressor when wild-type. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - BLOOD cholesterol
KW - ISOPENTENOIDS
KW - CARDIOPULMONARY system
KW - Cholesterol
KW - Cholestyramine
KW - K-ras activity
KW - Konjac mannan
KW - Lovastatin
KW - Lung
KW - Mice
KW - Niacin
N1 - Accession Number: 23206805; Calvert, Richard J. 1,2; Email Address: calvert@mail.ncifcrf.gov Tepper, Shirley 3 Kammouni, Wafa 2 Anderson, Lucy M. 2 Kritchevsky, David 3; Affiliation: 1: Division of Research and Applied Technology, Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA 2: Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Rm. 277, P.O. Box B, Frederick, MD 21702-1201, USA 3: The Wistar Institute, Philadelphia, PA 19104, USA; Source Info: Dec2006, Vol. 72 Issue 12, p1749; Subject Term: BLOOD plasma; Subject Term: BLOOD cholesterol; Subject Term: ISOPENTENOIDS; Subject Term: CARDIOPULMONARY system; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: Cholestyramine; Author-Supplied Keyword: K-ras activity; Author-Supplied Keyword: Konjac mannan; Author-Supplied Keyword: Lovastatin; Author-Supplied Keyword: Lung; Author-Supplied Keyword: Mice; Author-Supplied Keyword: Niacin; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bcp.2006.08.026
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Saiyasitpanich, Phirun
AU - Keener, Tim C.
AU - Mingming Lu
AU - Soon-Jai Khang
AU - Evans, Douglas E.
T1 - Collection of Ultrafine Diesel Particulate Matter (DPM) in Cylindrical Single-Stage Wet Electrostatic Precipitators.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2006/12/15/
VL - 40
IS - 24
M3 - Article
SP - 7890
EP - 7895
SN - 0013936X
AB - Long-term exposures to diesel particulate matter (DPM) emissions are linked to increasing adverse human health effects due to the potential association of DPM with carcinogenicity. Current diesel vehicular particulate emission regulations are based solely upon total mass concentration, albeit it is the submicrometer particles that are highly respirable and the most detrimental to human health. In this study, experiments were performed with a tubular single-stage wet electrostatic precipitator (wESP) to evaluate its performance for the removal of number-based DPM emissions. A nonroad diesel generator utilizing a low sulfur diesel fuel (500 ppmw) operating under varying load conditions was used as a stationary DPM emission source. An electrical low-pressure impactor (ELPI) was used to quantify the number concentration distributions of diesel particles in the diluted exhaust gas at each tested condition. The wESP was evaluated with respect to different operational control parameters such as applied voltage, gas residence time, etc., to determine their effect on overall collection efficiency, as well as particle size dependent collection efficiency. The results show that the total DPM number concentrations in the untreated diesel exhaust are in the magnitude of ∼108/cm3 at all engine loads with the particle diameter modes between 20 and 40 nm. The measured collection efficiency of the wESP operating at 70 kV based on total particle numbers was 86% at 0 kW engine load and the efficiency decreased to 67% at 75 kW due to a decrease in gas residence time and an increase in particle concentrations. At a constant wESP voltage of 70 kV and at 75 kW engine load, the variation of gas residence time within the wESP from ∼0.1 to ∼0.4 s led to a substantial increase in the collection efficiency from 67% to 96%. In addition, collection efficiency was found to be directly related to the applied voltage, with increasing collection efficiency measured for increases in applied voltage. The collection efficiency based on particle size had a minimum for sizes between 20 and 50 nm, but at optimal wESP operating conditions it was possible to remove over 90% of all particle sizes. A comparison of measured and calculated collection efficiencies reveals that the measured values are significantly higher than the predicted values based on the well-known Deutsch equation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diesel fuels
KW - Particulate matter
KW - Emissions (Air pollution)
KW - Public health
KW - Carcinogenicity
KW - Air pollution
KW - Environmental sciences
KW - Electrostatic precipitation
KW - Precipitation (Chemistry)
N1 - Accession Number: 23616376; Saiyasitpanich, Phirun 1; Keener, Tim C. 1; Email Address: Tim.Keener@uc.edu; Mingming Lu 1; Soon-Jai Khang 2; Evans, Douglas E. 3; Affiliations: 1: Department of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45221; 2: Department of Chemical and Material Engineering, University of Cincinnati, Cincinnati, Ohio 45221; 3: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 4676 Columbia Parkway MS-R3, Cincinnati, Ohio 45226; Issue Info: 12/15/2006, Vol. 40 Issue 24, p7890; Thesaurus Term: Diesel fuels; Thesaurus Term: Particulate matter; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Public health; Thesaurus Term: Carcinogenicity; Thesaurus Term: Air pollution; Thesaurus Term: Environmental sciences; Subject Term: Electrostatic precipitation; Subject Term: Precipitation (Chemistry); NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ke-Qin Xin
AU - Mizukami, Hiroaki
AU - Urabe, Masashi
AU - Toda, Yoshihiko
AU - Shinoda, Kaori
AU - Yoshida, Atsushi
AU - Oomura, Kenji
AU - Kojima, Yoshitsugu
AU - Ichino, Motohide
AU - Klinman, Dennis
AU - Ozawa, Keiya
AU - Okuda, Kenji
T1 - Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 for Dendritic Cells.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/12/15/
VL - 80
IS - 24
M3 - Article
SP - 1
EP - 1
SN - 0022538X
AB - The ability of adeno-associated virus serotype 1 to 8 (AAV1 to AAV8) vectors expressing the human immunodeficiency virus type 1 (HIV-1) Env gp160 (AAV-HIV) to induce an immune response was evaluated in BALB/c mice. The AAV5 vector showed a higher tropism for both mouse and human dendritic cells (DCs) than did the AAV2 vector, whereas other AAV serotype vectors transduced DCs only poorly. AAV1, AAV5, AAV7, and AAV8 were more highly expressed in muscle cells than AAV2. An immunogenicity study of AAV serotypes indicates that AAV1, AAV5, AAV7, and AAV8 vectors expressing the Env gp160 gene induced higher HIV-specific humoral and cell-mediated immune responses than the AAV2 vector did, with the AAV5 vector producing the best responses. Furthermore, mice injected with DCs that had been transduced ex vivo with an AAV5 vector expressing the gp160 gene elicited higher HIV-specific cell-mediated immune responses than did DCs transduced with AAV1 and AAV2 vectors. We also found that AAV vectors produced by HEK293 cells and insect cells elicit similar levels of antigen-specific immune responses. These results demonstrate that the immunogenicity of AAV vectors depends on their tropism for both antigen-presenting cells (such as DCs) and non-antigen-presenting cells (such as muscular cells) and that AAV5 is a better vector than other AAV serotypes. These results may aid in the development of AAV-based vaccine and gene therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - HIV (Viruses)
KW - IMMUNE response
KW - MICE as laboratory animals
KW - TROPISMS
KW - DENDRITIC cells
KW - ANIMAL genetic engineering
KW - GENE therapy
N1 - Accession Number: 23346670; Ke-Qin Xin 1 Mizukami, Hiroaki 2 Urabe, Masashi 2 Toda, Yoshihiko 1 Shinoda, Kaori 1 Yoshida, Atsushi 1 Oomura, Kenji 1 Kojima, Yoshitsugu 1 Ichino, Motohide 3 Klinman, Dennis 4 Ozawa, Keiya 2 Okuda, Kenji 1; Email Address: kokuda@med.yokohama-cu.ac.jp; Affiliation: 1: Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan 2: Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical School, Tochigi-ken 329-0498, Japan 3: Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan 4: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Dec2006, Vol. 80 Issue 24, p1; Subject Term: ADENOVIRUSES; Subject Term: HIV (Viruses); Subject Term: IMMUNE response; Subject Term: MICE as laboratory animals; Subject Term: TROPISMS; Subject Term: DENDRITIC cells; Subject Term: ANIMAL genetic engineering; Subject Term: GENE therapy; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.00890-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ovanesov, Mikhail V.
AU - Sauder, Christian
AU - Rubin, Steven A.
AU - Richt, Jürgen
AU - Nath, Avindra
AU - Carbone, Kathryn M.
AU - Pletnikov, Mikhail V.
T1 - Activation of Microglia by Borna Disease Virus Infection: In Vitro Study.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/12/15/
VL - 80
IS - 24
M3 - Article
SP - 35
EP - 35
SN - 0022538X
AB - Neonatal Borna disease virus (BDV) infection of the rat brain is associated with microglial activation and damage to the certain neuronal populations. Since persistent BDV infection of neurons in vitro is noncytolytic and noncytopathic, activated microglia have been suggested to be responsible for neuronal cell death in vivo. However, the mechanisms of activation of microglia in neonatally BDV-infected rat brain have not been investigated. To address these issues, activation of primary rat microglial cells was studied following exposure to purified BDV or to persistently BDV-infected primary cortical neurons or after BDV infection of primary mixed neuron-glial cultures. Neither purified virus nor BDV-infected neurons alone activated primary microglia as assessed by the changes in cell shape or production of the proinflammatory cytokines. In contrast, in the BDV-infected primary mixed cultures, we observed proliferation of microglia cells that acquired the round morphology and expressed major histocompatibility complex molecules of classes I and II. These manifestations of microglia activation were observed in the absence of direct BDV infection of microglia or overt neuronal toxicity. In addition, compared to uninfected mixed cultures, activation of microglia in BDV-infected mixed cultures was associated with a significantly greater lipopolysaccharide-induced release of tumor necrosis factor alpha, interleukin 1β, and interleukin 10. Taken together, the present data are the first in vitro evidence that persistent BDV infection of neurons and astrocytes rather than direct exposure to the virus or dying neurons is critical for activating microglia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORNA disease virus
KW - NEONATAL infections
KW - BRAIN damage
KW - BORNA disease
KW - MICROGLIA
KW - CYTOKINES
N1 - Accession Number: 23346703; Ovanesov, Mikhail V. 1,2 Sauder, Christian 2 Rubin, Steven A. 2 Richt, Jürgen 3 Nath, Avindra 4,5 Carbone, Kathryn M. 2 Pletnikov, Mikhail V. 1,2; Email Address: mpletnik@jhmi.edu; Affiliation: 1: Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland 2: CBER, U.S. Food and Drug Administration, Bethesda, Maryland 3: National Animal Disease Center, Ames, Iowa 4: Department of Neurology, Johns Hopkins University, Baltimore, Maryland 5: Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland; Source Info: Dec2006, Vol. 80 Issue 24, p35; Subject Term: BORNA disease virus; Subject Term: NEONATAL infections; Subject Term: BRAIN damage; Subject Term: BORNA disease; Subject Term: MICROGLIA; Subject Term: CYTOKINES; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.01648-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23346703&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu Ou
AU - Silver, Jonathan
T1 - Stoichiometry of Murine Leukemia Virus Envelope Protein-Mediated Fusion and Its Neutralization.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2006/12/15/
VL - 80
IS - 24
M3 - Article
SP - 41
EP - 41
SN - 0022538X
AB - Envelope glycoproteins (Envs) of retroviruses form trimers that mediate fusion between viral and cellular membranes and are the targets for neutralizing antibodies. Understanding in detail how Env trimers mediate membrane fusion, and how antibodies interfere with this process, is a fundamental problem in biology with practical implications for the development of antiviral drugs and vaccines. We investigated the stoichiometry of Env-mediated fusion and its inhibition by antibody by inserting an epitope from human immunodeficiency virus for a neutralizing antibody (2F5) into the surface (SU) or transmembrane (TM) protein of murine leukemia virus Env, along with point mutations that abrogate SU and TM function but complement one another. We transfected various combinations of these Env genes and investigated Env-mediated cell fusion and its inhibition by 2F5 antibody. Our results showed that heterotrimers with one functional SU molecule were fusion competent in complementation experiments and that one antibody molecule was sufficient to inactivate the fusion function of a trimer when its epitope was in functional SU or TM. 2F5 antibody could also neutralize trimers with the 2F5 epitope in nonfunctional SU or TM, but less efficiently. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - RETROVIRUSES
KW - VIRAL envelopes
KW - CELL membranes
KW - STOICHIOMETRY
KW - ANTIGENIC determinants
KW - MOUSE leukemia viruses
N1 - Accession Number: 23346709; Wu Ou 1,2 Silver, Jonathan 1; Email Address: jsilver@nih.gov; Affiliation: 1: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 2: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland; Source Info: Dec2006, Vol. 80 Issue 24, p41; Subject Term: GLYCOPROTEINS; Subject Term: RETROVIRUSES; Subject Term: VIRAL envelopes; Subject Term: CELL membranes; Subject Term: STOICHIOMETRY; Subject Term: ANTIGENIC determinants; Subject Term: MOUSE leukemia viruses; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.01318-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106245660
T1 - Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine -- recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel.
AU - Kretsinger K
AU - Broder KR
AU - Cortese MM
AU - Joyce MP
AU - Ortega-Sanchez I
AU - Lee GM
AU - Tiwari T
AU - Cohn AC
AU - Slade BA
AU - Iskander JK
AU - Mijalski CM
AU - Brown KH
AU - Murphy TV
Y1 - 2006/12/15/
N1 - Accession Number: 106245660. Language: English. Entry Date: 20070202. Revision Date: 20151021. Publication Type: Journal Article; CEU; exam questions; tables/charts. Journal Subset: Biomedical; Public Health; USA. NLM UID: 7802429.
KW - Diphtheria -- Prevention and Control
KW - Immunization
KW - Tetanus Toxoid -- Therapeutic Use
KW - Tetanus -- Prevention and Control
KW - Whooping Cough -- Prevention and Control
KW - Abbreviations
KW - Bacterial Vaccines -- Administration and Dosage
KW - Cost Benefit Analysis
KW - Education, Continuing (Credit)
KW - Female
KW - Health Personnel
KW - Infant
KW - Influenza Vaccine
KW - Practice Guidelines
KW - Pregnancy
KW - Program Implementation
KW - United States
KW - Vaccines -- Adverse Effects
KW - Vaccines -- Contraindications
KW - Vaccines, Combined
KW - Viral Hepatitis Vaccines
KW - Whooping Cough -- Epidemiology -- United States
SP - 1
EP - 36
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
JA - MMWR MORB MORTAL WKLY REP
VL - 55
IS - 49
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - On June 10, 2005, a tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) formulated for use in adults and adolescents was licensed in the United States for persons aged 11--64 years (ADACEL, manufactured by sanofi pasteur, Toronto, Ontario, Canada). Prelicensure studies demonstrated safety and efficacy, inferred through immunogenicity, against tetanus, diphtheria, and pertussis when Tdap was administered as a single booster dose to adults. To reduce pertussis morbidity among adults and maintain the standard of care for tetanus and diphtheria prevention and to reduce the transmission of pertussis to infants and in health-care settings, the Advisory Committee on Immunization Practices (ACIP) recommends that: 1) adults aged 19-64 years should receive a single dose of Tdap to replace tetanus and diphtheria toxoids vaccine (Td) for booster immunization against tetanus, diphtheria, and pertussis if they received their last dose of Td >10 years earlier and they have not previously received Tdap; 2) intervals shorter than 10 years since the last Td may be used for booster protection against pertussis; 3) adults who have or who anticipate having close contact with an infant aged <12 months (e.g., parents, grandparents aged <65 years, child-care providers, and health-care personnel) should receive a single dose of Tdap to reduce the risk for transmitting pertussis. An interval as short as 2 years from the last Td is suggested; shorter intervals can be used. When possible, women should receive Tdap before becoming pregnant. Women who have not previously received Tdap should receive a dose of Tdap in the immediate postpartum period; 4) health-care personnel who work in hospitals or ambulatory care settings and have direct patient contact should receive a single dose of Tdap as soon as feasible if they have not previously received Tdap. An interval as short as 2 years from the last dose of Td is recommended; shorter intervals may be used. These recommendations for use of Tdap in health-care personnel are supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC). This statement 1) reviews pertussis, tetanus and diphtheria vaccination policy in the United States; 2) describes the clinical features and epidemiology of pertussis among adults; 3) summarizes the immunogenicity, efficacy, and safety data of Tdap; and 4) presents recommendations for the use of Tdap among adults aged 19-64 years.
SN - 0149-2195
AD - Division of Bacterial Disease (proposed), Commissioned Corps of the United States Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Daniels, Robert D.
AU - Yiin, James H.
T1 - A COMPARISON OF STATISTICAL METHODS FOR ESTIMATION OF LESS THAN DETECTABLE IONISING RADIATION EXPOSURES.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2006/12/15/
VL - 121
IS - 3
M3 - Article
SP - 240
EP - 251
SN - 01448420
AB - Methods were developed to estimate the ionising radiation dose below the detection level (DL) of personal monitoring devices for a case-control study of protracted radiation exposure and lung cancer. Exposure data were grouped by dosemeter type and monitoring period. Each group contained dosimetry data that were interval-censored from limitations in measurement precision and included left-censoring of observations below detection. The grouped data were fit to a three parameter hybrid- lognormal distribution by maximum likelihood estimation. Using the fitted distribution, bootstrap samples were either simulated by Monte Carlo or constructed by sampling with replacement. The resulting bootstrap sample distributions were then used to predict the missing dose values and the associated uncertainty in the estimate. Among study subjects, 1357 workers were monitored with film dosimetry. Among the 39,263 dose observations 20,416 were recorded as zero dose, indicating 52% left-censoring. The statistical methods estimated 0.31 person-Sv below the DL or ~1% of the total collective dose for this study population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radiation
KW - Diseases -- Causes & theories of causation
KW - Health risk assessment
KW - Industrial safety
KW - Physics
KW - Public health
KW - Ionizing radiation -- Measurement
KW - Workplace exposure to hazardous substances
KW - Dynamics
N1 - Accession Number: 24040429; Daniels, Robert D. 1; Email Address: rtd2@cdc.gov; Yiin, James H. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA; Issue Info: 2006, Vol. 121 Issue 3, p240; Thesaurus Term: Radiation; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial safety; Thesaurus Term: Physics; Thesaurus Term: Public health; Subject Term: Ionizing radiation -- Measurement; Subject Term: Workplace exposure to hazardous substances; Subject Term: Dynamics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Illustrations: 1 Diagram, 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1093/rpd/ncl024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24040429&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sullivan, Lynn E.
AU - Bruce, Robert D.
AU - Haltiwanger, David
AU - Lucas, Gregory M.
AU - Eldred, Lois
AU - Finkelstein, Ruth
AU - Fiellin, David A.
T1 - Initial Strategies for Integrating Buprenorphine into HIV Care Settings in the United States.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2006/12/16/12/15/2006 Supplement
VL - 43
M3 - Article
SP - S191
EP - S196
SN - 10584838
AB - The Centers for Disease Control and Prevention's HIV Prevention Strategic Plan Through 2005 advocated for increasing the proportion of persons with human immunodeficiency virus (HIV) infection and in need of substance abuse treatment who are successfully linked to services for these 2 conditions. There is evidence that integrating care for HIV infection and substance abuse optimizes outcomes for patients with both disorders. Buprenorphine, a recently approved medication for the treatment of opioid dependence in physicians' offices, provides the opportunity to integrate the treatment of HIV infection and substance abuse in one clinical setting, yet little information exists on the models of care that will most successfully facilitate this integration. To promote the uptake of this type of integrated care, the current review provides a description of 4 recently implemented models for combining buprenorphine treatment with HIV primary care: (1) an on-site addiction/HIV specialist treatment model; (2) a HIV primary care physician model; (3) a nonphysician health professional model; and (4) a community outreach model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Medical care
KW - HIV-positive persons
KW - Buprenorphine
KW - HIV infections -- Prevention
KW - United States
N1 - Accession Number: 23490801; Sullivan, Lynn E. 1; Email Address: lynn.sullivan@yale.edu; Bruce, Robert D. 1; Haltiwanger, David 2; Lucas, Gregory M. 3; Eldred, Lois 4; Finkelstein, Ruth 5; Fiellin, David A. 1; Affiliations: 1: Yale University School of Medicine, New Haven, Connecticut.; 2: Chase Brexton Health Services, New Haven, Connecticut.; 3: Johns Hopkins University, Baltimore.; 4: Health Resources and Services Administration, Rockville, Maryland.; 5: New York Academy of Medicine, New York.; Issue Info: 12/15/2006 Supplement, Vol. 43, pS191; Thesaurus Term: Communicable diseases; Subject Term: Medical care; Subject Term: HIV-positive persons; Subject Term: Buprenorphine; Subject Term: HIV infections -- Prevention; Subject: United States; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Easley, Christopher J.
AU - Karlinsey, James M.
AU - Bienvenue, Joan M.
AU - Legendre, Lindsay A.
AU - Roper, Michael G.
AU - Feldman, Sanford H.
AU - Hughes, Molly A.
AU - Hewlett, Erik L.
AU - Merkel, Tod J.
AU - Ferrance, Jerome P.
AU - Landers, James P.
T1 - A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2006/12/19/
VL - 103
IS - 51
M3 - Article
SP - 19272
EP - 19277
SN - 00278424
AB - We describe a microfluidic genetic analysis system that represents a previously undescribed integrated microfluidic device capable of accepting whole blood as a crude biological sample with the endpoint generation of a genetic profile. Upon loading the sample, the glass microfluidic genetic analysis system device carries out on-chip DNA purification and PCR-based amplification, followed by separation and detection in a manner that allows for microliter samples to be screened for infectious pathogens with sample-in-answer-out results in <30 mm. A single syringe pump delivers sample/reagents to the chip for nucleic acid purification from a biological sample. Elastomeric membrane valving isolates each distinct functional region of the device and, together with resistive flow, directs purified DNA and PCR reagents from the extraction domain into a 550-nl chamber for rapid target sequence PCR amplification. Repeated pressure-based injections of nanoliter aliquots of amplicon (along with the DNA sizing standard) allow electrophoretic separation and detection to provide DNA fragment size information. The presence of Bacillus anthracis (anthrax) in 750 nl of whole blood from living asymptomatic infected mice and of Bordetella pertussis in 1 µl of nasal aspirate from a patient suspected of having whooping cough are confirmed by the resultant genetic profile. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROFLUIDICS
KW - BLOOD
KW - DNA
KW - RESEARCH
KW - MEDICAL screening
KW - PATHOGENIC microorganisms
KW - full integration
KW - micro total analysis system
KW - microdevice
KW - pumping
KW - valving
N1 - Accession Number: 23873294; Easley, Christopher J. 1 Karlinsey, James M. 1 Bienvenue, Joan M. 1 Legendre, Lindsay A. 1 Roper, Michael G. 1 Feldman, Sanford H. 2 Hughes, Molly A. 3 Hewlett, Erik L. 3 Merkel, Tod J. 4 Ferrance, Jerome P. 1 Landers, James P. 1,5; Email Address: landers@virginia.edu; Affiliation: 1: Department of Chemistry, University of Virginia, Charlottesville, VA 22904 2: Departments of Comparative Medicine, University of Virginia Health System, Charlottesville, VA 22908 3: lnfectious Disease, University of Virginia Health System, Charlottesville, VA 22908 4: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 28092 5: PathoIogy, University of Virginia Health System, Charlottesville, VA 22908; Source Info: 12/19/2006, Vol. 103 Issue 51, p19272; Subject Term: MICROFLUIDICS; Subject Term: BLOOD; Subject Term: DNA; Subject Term: RESEARCH; Subject Term: MEDICAL screening; Subject Term: PATHOGENIC microorganisms; Author-Supplied Keyword: full integration; Author-Supplied Keyword: micro total analysis system; Author-Supplied Keyword: microdevice; Author-Supplied Keyword: pumping; Author-Supplied Keyword: valving; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1073/pnas.0604663103
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Introcaso, David M.
T1 - Remaking American Medicine.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2006/12/20/
VL - 296
IS - 23
M3 - Entertainment Review
SP - 2860
EP - 2861
SN - 00987484
AB - A review of the DVD release of the television series "Remaking American Medicine," produced by Crosskeys Media, is presented.
KW - TELEVISION programs -- Reviews
KW - CROSSKEYS Media (Company)
KW - CORPORATION for Public Broadcasting
KW - REMAKING American Medicine: Health Care for the 21st Century (TV program)
N1 - Accession Number: 23525286; Introcaso, David M. 1; Email Address: david.introcaso@hhs.gov; Affiliation: 1: Health Policy Analyst, Office of Health Policy Office of the Assistant Secretary for Planning & Evaluation US Department of Health and Human Services; Source Info: 12/20/2006, Vol. 296 Issue 23, p2860; Subject Term: TELEVISION programs -- Reviews; Company/Entity: CROSSKEYS Media (Company) Company/Entity: CORPORATION for Public Broadcasting; Reviews & Products: REMAKING American Medicine: Health Care for the 21st Century (TV program); Number of Pages: 2p; Document Type: Entertainment Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Earnest, G. Scott
AU - Reed, Laurence D.
AU - Conover, D.
AU - Estill, C.
AU - Gjessing, C.
AU - Gressel, M.
AU - Hall, R.
AU - Hudock, S.
AU - Hudson, H.
AU - Kardous, C.
AU - Sheehy, J.
AU - Topmiller, J.
AU - Trout, D.
AU - Woebkenberg, M.
AU - Amendola, A.
AU - Hsiao, H.
AU - Keane, P.
AU - Weissman, D.
AU - Finfinger, G.
AU - Tadolini, S.
T1 - Engineering and Public Health at CDC.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2006/12/23/12/23/2006 Supplement
VL - 55
M3 - Article
SP - 10
EP - 13
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article focuses on the role of engineering in the U.S. Communicable Disease Center (CDC). It defines engineering as the science of applying scientific and technical knowledge in the solution of human problems. In the 1940s, CDC engineers helped in the elimination of standing water as a source of malaria. Their mission eventually included the development of chlorination for the prevention of water-borne diseases and regulating industrial safety engineering at the U.S. National Institute for Occupational Safety and Health (NIOSH).
KW - ENGINEERING
KW - ENGINEERS
KW - WATER
KW - MALARIA
KW - CHLORINATION
KW - WATERBORNE infection
KW - INDUSTRIAL safety
KW - UNITED States
N1 - Accession Number: 41233455; Earnest, G. Scott 1; Email Address: gearnest@cdc.gov Reed, Laurence D. 2 Conover, D. 1 Estill, C. 2 Gjessing, C. 1 Gressel, M. 1 Hall, R. 1 Hudock, S. 1 Hudson, H. 1 Kardous, C. 1 Sheehy, J. 1 Topmiller, J. 1 Trout, D. 2 Woebkenberg, M. 1 Amendola, A. 3 Hsiao, H. 3 Keane, P. 3 Weissman, D. 4 Finfinger, G. 5 Tadolini, S. 5; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC 2: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC 3: Division of Safety Research, National Institute for Occupational Safety and Health, CDC 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC 5: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, CDC; Source Info: 12/23/2006 Supplement, Vol. 55, p10; Subject Term: ENGINEERING; Subject Term: ENGINEERS; Subject Term: WATER; Subject Term: MALARIA; Subject Term: CHLORINATION; Subject Term: WATERBORNE infection; Subject Term: INDUSTRIAL safety; Subject Term: UNITED States; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sieber Jr., William K.
AU - Green, T.
AU - Williamson, G. D.
T1 - Statistics and Public Health at CDC.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2006/12/23/12/23/2006 Supplement
VL - 55
M3 - Article
SP - 22
EP - 24
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article explains how statistics is used at the U.S. Communicable Disease Center in guiding actions and policies for the improvement of public health. It says that statistics provide sources of vital health records through the surveys, interviews, physical examinations and laboratory tests conducted by the CDC. Data gathered are analyzed to track health trends that guide the center in developing appropriate research and analytic methods for several coordinating centers including the National Institute for Occupational Safety and Health (NIOSH).
KW - STATISTICS
KW - PUBLIC health
KW - MEDICAL records
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 41233459; Sieber Jr., William K. 1; Email Address: wsieber@cdc.gov Green, T. 2 Williamson, G. D. 3; Affiliation: 1: National Institute for Occupational Safety and Health 2: National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 3: Agency for Toxic Substances and Disease Registry; Source Info: 12/23/2006 Supplement, Vol. 55, p22; Subject Term: STATISTICS; Subject Term: PUBLIC health; Subject Term: MEDICAL records; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106245654
T1 - Statistics and public health at CDC.
AU - Sieber WK Jr.
AU - Green T
AU - Williamson GD
Y1 - 2006/12/23/12/23/2006 Supplement
N1 - Accession Number: 106245654. Language: English. Entry Date: 20070309. Revision Date: 20151015. Publication Type: Journal Article; pictorial. Supplement Title: 12/23/2006 Supplement. Journal Subset: Biomedical; Public Health; USA. NLM UID: 7802429.
KW - Centers for Disease Control and Prevention (U.S.)
KW - Public Health
KW - Statistics
KW - United States
SP - 22
EP - 24
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
JA - MMWR MORB MORTAL WKLY REP
VL - 55
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
SN - 0149-2195
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226; wsieber@cdc.gov
U2 - PMID: 17183239.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2007-12124-004
AN - 2007-12124-004
AU - Clark, H. Westley
ED - Henningfield, Jack E.
ED - Santora, Patricia B.
ED - Bickel, Warren K.
ED - Henningfield, Jack E., (Ed)
ED - Santora, Patricia B., (Ed)
ED - Bickel, Warren K., (Ed)
T1 - Office-based treatment of addiction and the promise of technology.
T2 - Addiction treatment: Science and policy for the twenty-first century.
Y1 - 2007///
SP - 45
EP - 50
CY - Baltimore, MD, US
PB - Johns Hopkins University Press
SN - 0-8018-8669-4
SN - 978-0-8018-8669-0
N1 - Accession Number: 2007-12124-004. Partial author list: First Author & Affiliation: Clark, H. Westley; Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20080324. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8018-8669-4, Hardcover; 978-0-8018-8669-0, Hardcover. Language: English. Major Descriptor: Addiction; Drug Abuse; Drug Dependency; Opiates; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 6.
AB - Many physicians question whether they should be involved in treating opioid-dependent patients. This chapter will address some of the issues, obstacles, and the potential for reform and for office-based treatment of addiction. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - office based treatment
KW - addiction
KW - substance abuse
KW - opiate dependency
KW - 2007
KW - Addiction
KW - Drug Abuse
KW - Drug Dependency
KW - Opiates
KW - Treatment
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12124-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kwang Seok Choi
AU - Yamaguma, Mizuki
AU - Ohsawa, Atsushi
T1 - Ignitability of sprayed liquids due to an electrostatic spark.
JO - Advanced Powder Technology
JF - Advanced Powder Technology
Y1 - 2007/01//
VL - 18
IS - 1
M3 - Article
SP - 105
EP - 115
PB - Elsevier Science
SN - 09218831
AB - The minimum ignition energy (MIE) is a reasonable and practical index to assess the ignition risk of flammable materials. This paper reports the results of experiments dealing with the MIE due to an electrostatic spark of a sprayed liquid under various conditions. Four kinds of liquid (kerosene, n-decane, m-xylene and styrene) were used as the materials in this study. The liquid was pneumatically conveyed to the spray gun and automatically sprayed for 7 s to measure the MIE. The spatial distribution of the MIE in the spraying liquid under various conditions was also investigated in this study. The following results were obtained. (i) In the normal temperature range (0–30°C), all sprayed liquids can be ignited by a spark with a discharge energy below 10 mJ irrespective of their flash point. In particular, styrene was ignited at 4 mJ. (ii) An optimum region for ignition in a spraying liquid was observed, and it depended on the velocity, concentration and particle size of the liquid. Experimental details and a discussion are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Advanced Powder Technology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAMMABLE materials
KW - KEROSENE
KW - XYLENE
KW - STYRENE
KW - SPRAYING
KW - Electrostatic spark
KW - IGNITABILITY
KW - liquid
KW - MINIMUM IGNITION ENERGY
N1 - Accession Number: 23849534; Kwang Seok Choi 1; Email Address: choiks@s.jniosh.go.jp Yamaguma, Mizuki 1 Ohsawa, Atsushi 1; Affiliation: 1: Independent Administrative Institution, Japan National Institute of Occupational Safety and Health, 1-4-6 Umezono, Kiyose, Tokyo 204-0024, Japan; Source Info: 2007, Vol. 18 Issue 1, p105; Subject Term: FLAMMABLE materials; Subject Term: KEROSENE; Subject Term: XYLENE; Subject Term: STYRENE; Subject Term: SPRAYING; Author-Supplied Keyword: Electrostatic spark; Author-Supplied Keyword: IGNITABILITY; Author-Supplied Keyword: liquid; Author-Supplied Keyword: MINIMUM IGNITION ENERGY; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 11p; Illustrations: 3 Color Photographs, 1 Diagram, 6 Charts, 1 Graph; Document Type: Article
L3 - 10.1163/156855207779768115
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23849534&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106147963
T1 - Emergency departments in crisis: implications for accessibility, quality, and safety.
AU - Clancy CM
Y1 - 2007/01//Jan/Feb2007
N1 - Accession Number: 106147963. Language: English. Entry Date: 20070907. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9300756.
KW - Emergency Service -- Standards
KW - Health Services Accessibility
KW - Patient Safety
KW - Quality of Health Care
KW - Disasters
KW - Emergency Service -- Administration
KW - Treatment Errors -- Prevention and Control
KW - United States
SP - 59
EP - 62
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 22
IS - 1
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, MD, USA.
U2 - PMID: 17227879.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Erdely, Aaron
AU - Freshour, Gary
AU - You-Lin Tam
AU - Engels, Kevin
AU - Baylis, Chris
T1 - DOCA/NaC1-induced chronic kidney disease: a comparison of renal nitric oxide production in resistant and susceptible rat strains.
JO - American Journal of Physiology: Renal Physiology
JF - American Journal of Physiology: Renal Physiology
Y1 - 2007/01//
VL - 61
IS - 1
M3 - Article
SP - F192
EP - F196
SN - 1931857X
AB - Recent studies show nitric oxide (NO) deficiency is both a cause and consequence of chronic kidney disease (CKD). Reduced renal neuronal NO synthase (nNOS) abundance and activity parallel development of CKD with different models in the Sprague-Dawley (SD) rats, whereas Wistar Furth (WF) rats are protected against CKD and show preserved renal NO production. In this study, we compared renal NO in response to DOCA/salt-induced injury between the WF and SD. Studies were conducted on sham WF (n = 6) and SD (n = 6) and uninephrectized (UNX)+75 mg DOCA+1% NaCl (WF n = 9; SD n = 10) rats followed for 5 wk. Kidneys were harvested for Western blot, NOS activity, and histology. Other measurements included creatinine clearance and 24-h total NO production and urinary protein excretion. Absolute values of kidney weight were lower in WF than SD rats that showed similar percent increases with UNX+DOCA/NaCI. Proteinuria and decreased creatinine clearance were present in the SD but not the WF rats following UNX+DOCA/NaCl. Glomerular injury was mild in the WF compared with SD rats that showed many globally damaged glomeruli. Although renal nNOS abundance was decreased in both strains (higher baseline in WF), soluble NOS activity was maintained in the WF but significantly reduced in the SD rats. Renal endothelial NOS abundance and membrane NOS activity were unaffected by treatment. In summary, WF rats showed resistance to UNX+DOCA/NaCl-induced CKD with maintained renal NO production despite mild reduction in nNOS abundance. Further studies are needed to evaluate how WF rats maintain renal NO production despite similar changes in abundance as the vulnerable SD strain. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC kidney failure
KW - NITRIC oxide
KW - KIDNEY diseases
KW - NITRIC-oxide synthases
KW - RATS -- Physiology
KW - creatinine clearance
KW - endothelial nitric oxide synthase
KW - glomeruloscierosis
KW - neuronal nitric oxide synthase
KW - nitric oxide synthase activity
N1 - Accession Number: 23805392; Erdely, Aaron 1,2 Freshour, Gary 3 You-Lin Tam 4,5 Engels, Kevin 1 Baylis, Chris 4; Email Address: baylisc@ufl.edu; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 2: Department of Toxicology and Molecular Biology Branch, National Institute of Occupational Safety and Health, Morgantown, West Virginia 3: Department of Nutrition, West Virginia University, Morgantown, West Virginia 4: Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 5: Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan; Source Info: Jan2007, Vol. 61 Issue 1, pF192; Subject Term: CHRONIC kidney failure; Subject Term: NITRIC oxide; Subject Term: KIDNEY diseases; Subject Term: NITRIC-oxide synthases; Subject Term: RATS -- Physiology; Author-Supplied Keyword: creatinine clearance; Author-Supplied Keyword: endothelial nitric oxide synthase; Author-Supplied Keyword: glomeruloscierosis; Author-Supplied Keyword: neuronal nitric oxide synthase; Author-Supplied Keyword: nitric oxide synthase activity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Illustrations: 1 Chart, 12 Graphs; Document Type: Article
L3 - 10.1152/ajprenal.00146.2006
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2007-16521-012
AN - 2007-16521-012
AU - Meinke, Deanna K.
AU - Stephenson, Mark R.
ED - Ackley, R. Steven
ED - Decker, T. Newell
ED - Limb, Charles J.
ED - Ackley, R. Steven, (Ed)
ED - Decker, T. Newell, (Ed)
ED - Limb, Charles J., (Ed)
T1 - Noise-induced hearing loss: Models for prevention.
T2 - An essential guide to hearing and balance disorders.
Y1 - 2007///
SP - 287
EP - 323
CY - Mahwah, NJ, US
PB - Lawrence Erlbaum Associates Publishers
SN - 0-8058-5893-8
SN - 978-0-8058-5893-8
SN - 0-8058-5894-6
SN - 978-0-8058-5894-5
SN - 1-4106-1775-0
SN - 978-1-4106-1775-0
AD - Meinke, Deanna K., University of Northern Colorado, Greeley, CO, US, 80639
N1 - Accession Number: 2007-16521-012. Partial author list: First Author & Affiliation: Meinke, Deanna K.; University of Northern Colorado, Greeley, CO, US. Release Date: 20080324. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Textbook/Study Guide. ISBN: 0-8058-5893-8, Hardcover; 978-0-8058-5893-8, Hardcover; 0-8058-5894-6, Paperback; 978-0-8058-5894-5, Paperback; 1-4106-1775-0, PDF; 978-1-4106-1775-0, PDF. Language: English. Major Descriptor: Hearing Disorders; Noise Effects; Prevention. Minor Descriptor: Health Education; Human Development; Medical Treatment (General); Preventive Medicine; Risk Factors. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 37.
AB - Noise-induced hearing loss (NIHL) might be more accurately termed sound-induced hearing loss. loss. Noise exposure primarily damages the delicate hair cells in the cochlea. This defines NIHL as a 'sensory' hearing loss. Typically, excessive sound exposure results in hearing loss that is most extreme at 3-, 4-, or 6 kHz frequencies. NIHL is so frequently considered irreversible that it becomes synonymous with a condition known as 'noise-induced permanent threshold shift' (NIPTS), which does not always develop gradually. The authors discuss the developmental risk of NIHL and adult exposure risk. Then they present hearing loss prevention models and regulatory prevention. Educational models for hearing loss prevention are also described. A medical treatment model of hearing loss prevention is introduced, as is a preventive medicine model. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - noise induced hearing loss
KW - prevention
KW - developmental risk factors
KW - exposure risk factors
KW - preventive medicine
KW - educative prevention
KW - medical treatment prevention
KW - 2007
KW - Hearing Disorders
KW - Noise Effects
KW - Prevention
KW - Health Education
KW - Human Development
KW - Medical Treatment (General)
KW - Preventive Medicine
KW - Risk Factors
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16521-012&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Binns, Helen J.
AU - Lanier, David
AU - Pace, Wilson D.
AU - Galliher, James M.
AU - Ganiats, Theodore G.
AU - Grey, Margaret
AU - Ariza, Adolfo J.
AU - Williams, Robert
T1 - Describing Primary Care Encounters: The Primary Care Network Survey and the National Ambulatory Medical Care Survey.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2007/01//Jan/Feb2007
VL - 5
IS - 1
M3 - Article
SP - 39
EP - 47
PB - Annals of Family Medicine
SN - 15441709
AB - The article presents a study that describes clinical encounters in primary care research networks and compares them with those of the National Ambulatory Medical Care Survey (NAMCS). Primary care research networks collected data on clinicians and patient encounters using the Primary Care Network Survey (PRINS) Clinician Interview and Patient Record. PRINS presents a view of diverse primary care visits and differs from NAMCS in its methods and findings.
KW - MEDICAL care surveys
KW - PRIMARY care (Medicine)
KW - MEDICAL personnel
KW - PATIENTS
KW - MEDICAL records
KW - OUTPATIENT medical care
KW - INTERVIEWS
KW - allied health personnel
KW - ambulatory care
KW - health care delivery
KW - health services research
KW - office visits
KW - physicians
KW - Practice-based research
KW - prevention
KW - primary care
KW - survey methods
N1 - Accession Number: 23898676; Binns, Helen J. 1,2,3,4,5; Email Address: hbinns@northwestern.edu Lanier, David 6 Pace, Wilson D. 7 Galliher, James M. 8 Ganiats, Theodore G. 9 Grey, Margaret 10 Ariza, Adolfo J. 1,2,3,4,5 Williams, Robert 11; Affiliation: 1: Pediatric Practice Research Group (PPRG), Feinberg School of Medicine, Northwestern University, Chicago, Ill 2: Mary Ann and J. Milburn Smith Child Health Research Program, Feinberg School of Medicine, Northwestern University, Chicago, Ill 3: Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Ill 4: Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Ill 5: Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill 6: Agency for Healthcare Research and Quality, Rockville, Md 7: Colorado Research Network (CaReNet), Department of Family Medicine, University of Colorado Health Sciences Center, Aurora, Colo 8: American Academy of Family Physicians National Research Network (AAFP NRN), Leawood, Kan, and Department of Sociology, University of Missouri, Kansas City, Mo 9: San Diego Unified Research in Family Medicine Network (SURF*NET), Family and Preventive Medicine, University of California at San Diego, La Jolla, Calif 10: Advanced Practice Registered Nurse Research Network (APRNet), Yale School of Nursing, Yale University, New Haven, Conn 11: Research Involving Outpatient Settings Network (RIOSNet), University of New Mexico School of Medicine, Albuquerque, NM; Source Info: Jan/Feb2007, Vol. 5 Issue 1, p39; Subject Term: MEDICAL care surveys; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL personnel; Subject Term: PATIENTS; Subject Term: MEDICAL records; Subject Term: OUTPATIENT medical care; Subject Term: INTERVIEWS; Author-Supplied Keyword: allied health personnel; Author-Supplied Keyword: ambulatory care; Author-Supplied Keyword: health care delivery; Author-Supplied Keyword: health services research; Author-Supplied Keyword: office visits; Author-Supplied Keyword: physicians; Author-Supplied Keyword: Practice-based research; Author-Supplied Keyword: prevention; Author-Supplied Keyword: primary care; Author-Supplied Keyword: survey methods; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; Number of Pages: 9p; Document Type: Article
L3 - 10.1370/afm.620
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23898676&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BRIAN D. CURWIN
AU - MISTY J. HEIN
AU - WAYNE T. SANDERSON
AU - CYNTHIA STRILEY
AU - DICK HEEDERIK
AU - HANS KROMHOUT
AU - STEPHEN J. REYNOLDS
AU - MICHAEL C. ALAVANJA
T1 - Urinary Pesticide Concentrations Among Children, Mothers and Fathers Living in Farm and Non-Farm Households in Iowa.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2007/01//
VL - 51
IS - 1
M3 - Article
SP - 53
EP - 65
SN - 00034878
AB - In the spring and summer of 2001, 47 fathers, 48 mothers and 117 children of Iowa farm and non-farm households were recruited to participate in a study investigating take-home pesticide exposure. On two occasions ∼1 month apart, urine samples from each participant and dust samples from various rooms were collected from each household and were analyzed for atrazine, metolachlor, glyphosate and chlorpyrifos or their metabolites. The adjusted geometric mean (GM) level of the urine metabolite of atrazine was significantly higher in fathers, mothers and children from farm households compared with those from non-farm households (P ≤ 0.0001). Urine metabolites of chlorpyrifos were significantly higher in farm fathers (P = 0.02) and marginally higher in farm mothers (P = 0.05) when compared with non-farm fathers and mothers, but metolachlor and glyphosate levels were similar between the two groups. GM levels of the urinary metabolites for chlorpyrifos, metolachlor and glyphosate were not significantly different between farm children and non-farm children. Farm children had significantly higher urinary atrazine and chlorpyrifos levels (P = 0.03 and P = 0.03 respectively) when these pesticides were applied by their fathers prior to sample collection than those of farm children where these pesticides were not recently applied. Urinary metabolite concentration was positively associated with pesticide dust concentration in the homes for all pesticides except atrazine in farm mothers; however, the associations were generally not significant. There were generally good correlations for urinary metabolite levels among members of the same family. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDES -- Environmental aspects -- Measurement
KW - URINALYSIS
KW - CHOLINESTERASE-inhibiting insecticides
KW - IOWA
N1 - Accession Number: 23648001; BRIAN D. CURWIN 1 MISTY J. HEIN 1 WAYNE T. SANDERSON 2 CYNTHIA STRILEY 3 DICK HEEDERIK 4 HANS KROMHOUT 4 STEPHEN J. REYNOLDS 5 MICHAEL C. ALAVANJA 6; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies Cincinnati, OH, USA 2: University of Iowa, Department of Occupational and Environmental Health Iowa City, IA, USA 3: National Institute for Occupational Safety and Health, Division of Applied Research and Technology Cincinnati, OH, USA 4: Institute for Risk Assessment Sciences, Utrecht University Utrecht, The Netherlands 5: Colorado State University, Department of Environmental and Radiological Health Sciences Fort Collins, CO, USA 6: National Cancer Institute, Division of Cancer Epidemiology and Genetics Rockville, MD, USA; Source Info: Jan2007, Vol. 51 Issue 1, p53; Subject Term: PESTICIDES -- Environmental aspects -- Measurement; Subject Term: URINALYSIS; Subject Term: CHOLINESTERASE-inhibiting insecticides; Subject Term: IOWA; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GREGORY A. DAY
AU - ANDRÉ DUFRESNE
AU - ALEKSANDR B. STEFANIAK
AU - CHRISTINE R. SCHULER
AU - MARCIA L. STANTON
AU - WILLIAM E. MILLER
AU - MICHAEL S. KENT
AU - DAVID C. DEUBNER
AU - KATHLEEN KREISS
AU - MARK D. HOOVER
T1 - Exposure Pathway Assessment at a Copper–Beryllium Alloy Facility.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2007/01//
VL - 51
IS - 1
M3 - Article
SP - 67
EP - 80
SN - 00034878
AB - Controlling beryllium inhalation exposures to comply with regulatory levels (2 μg m−3 of air) does not appear to prevent beryllium sensitization and chronic beryllium disease (CBD). Additionally, it has proven difficult to establish a clear inhalation exposure–response relationship for beryllium sensitization and CBD. Thus, skin may be an important route of exposure that leads to beryllium sensitization. A 2000 survey had identified prevalence of sensitization (7%) and CBD (4%) in a beryllium alloy facility. An improved particulate migration control program, including dermal protection in production areas, was completed in 2002 at the facility. The purpose of this study was to evaluate levels of beryllium in workplace air, on work surfaces, on cotton gloves worn by employees over nitrile gloves, and on necks and faces of employees subsequent to implementation of the program. Over a 6 day period, we collected general area air samples (n = 10), wipes from routinely handled work surfaces (n = 252), thin cotton glove samples (n = 113) worn by employees, and neck wipes (n = 109) and face wipes (n = 109) from the same employees. In production, production support and office areas geometric mean (GM) levels of beryllium were 0.95, 0.59 and 0.05 μg per 100 cm2 on work surfaces; 42.8, 73.8 and 0.07 μg per sample on cotton gloves; 0.07, 0.09 and 0.003 μg on necks; and 0.07, 0.12 and 0.003 μg on faces, respectively. Correlations were strong between beryllium in air and on work surfaces (r = 0.79), and between beryllium on cotton gloves and on work surfaces (0.86), necks (0.87) and faces (0.86). This study demonstrates that, even with the implementation of control measures to reduce skin contact with beryllium as part of a comprehensive workplace protection program, measurable levels of beryllium continue to reach the skin of workers in production and production support areas. Based on our current understanding of the multiple exposure pathways that may lead to sensitization, we support prudent control practices such as use of protective gloves to minimize skin exposure to beryllium salts and fine particles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINERAL industries -- Dust control
KW - COPPER-beryllium alloys
KW - MINERAL dusts
KW - TRANSFER factor (Immunology)
N1 - Accession Number: 23647996; GREGORY A. DAY 1 ANDRÉ DUFRESNE 1 ALEKSANDR B. STEFANIAK 1 CHRISTINE R. SCHULER 1 MARCIA L. STANTON 1 WILLIAM E. MILLER 1 MICHAEL S. KENT 2 DAVID C. DEUBNER 2 KATHLEEN KREISS 1 MARK D. HOOVER 1; Affiliation: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) Division of Respiratory Disease Studies, Morgantown, WV 26505, USA 2: Brush Wellman Incorporated, Elmore OH 43416, USA; Source Info: Jan2007, Vol. 51 Issue 1, p67; Subject Term: MINERAL industries -- Dust control; Subject Term: COPPER-beryllium alloys; Subject Term: MINERAL dusts; Subject Term: TRANSFER factor (Immunology); Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106266391
T1 - Are children really safeguarded in the UK health service?
AU - Graham C
Y1 - 2007/01//
N1 - Accession Number: 106266391. Language: English. Entry Date: 20070413. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Harris D, Patel T, Dunne J, Maconochie IK. Implementation of the healthcare recommendations arising from the Victoria Climbié report. (ARCH DIS CHILD) Jan2007; 92 (1): 71-72. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0372434.
KW - Child Abuse -- Prevention and Control
KW - Child Health Services -- Standards
KW - Child Welfare -- Legislation and Jurisprudence
KW - Attitude of Health Personnel
KW - Child
KW - Child Abuse -- Legislation and Jurisprudence
KW - Child, Preschool
KW - National Health Programs
KW - Quality of Health Care
KW - United Kingdom
SP - 4
EP - 5
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
JA - ARCH DIS CHILD
VL - 92
IS - 1
PB - BMJ Publishing Group
SN - 0003-9888
AD - National Public Health Service, Preswylfa Hendy Road Mold, Wales CH7 1PZ, UK. carys.graham@nphs.wales.nhs.uk
U2 - PMID: 17185440.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Branham, William S
AU - Melvin, Cathy D
AU - Han, Tao
AU - Desai, Varsha G
AU - Moland, Carrie L
AU - Scully, Adam T
AU - Fuscoe, James C
T1 - Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements.
JO - BMC Biotechnology
JF - BMC Biotechnology
Y1 - 2007/01//
VL - 7
M3 - Article
SP - 8
EP - 8
PB - BioMed Central
SN - 14726750
AB - Background: Environmental ozone can rapidly degrade cyanine 5 (Cy5), a fluorescent dye commonly used in microarray gene expression studies. Cyanine 3 (Cy3) is much less affected by atmospheric ozone. Degradation of the Cy5 signal relative to the Cy3 signal in 2-color microarrays will adversely reduce the Cy5/Cy3 ratio resulting in unreliable microarray data. Results: Ozone in central Arkansas typically ranges between ∼22 ppb to ∼46 ppb and can be as high as 60-100 ppb depending upon season, meteorological conditions, and time of day. These levels of ozone are common in many areas of the country during the summer. A carbon filter was installed in the laboratory air handling system to reduce ozone levels in the microarray laboratory. In addition, the airflow was balanced to prevent non-filtered air from entering the laboratory. These modifications reduced the ozone within the microarray laboratory to ∼2-4 ppb. Data presented here document reductions in Cy5 signal on both in-house produced microarrays and commercial microarrays as a result of exposure to unfiltered air. Comparisons of identically hybridized microarrays exposed to either carbon-filtered or unfiltered air demonstrated the protective effect of carbon-filtration on microarray data as indicated by Cy5 and Cy3 intensities. LOWESS normalization of the data was not able to completely overcome the effect of ozoneinduced reduction of Cy5 signal. Experiments were also conducted to examine the effects of high humidity on microarray quality. Modest, but significant, increases in Cy5 and Cy3 signal intensities were observed after 2 or 4 hours at 98-99% humidity compared to 42% humidity. Conclusion: Simple installation of carbon filters in the laboratory air handling system resulted in low and consistent ozone levels. This allowed the accurate determination of gene expression by microarray using Cy5 and Cy3 fluorescent dyes. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Biotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - DNA microarrays
KW - DNA
KW - DYES & dyeing
KW - OZONE
N1 - Accession Number: 28858405; Branham, William S 1; Email Address: william.branham@fda.hhs.gov Melvin, Cathy D 2; Email Address: cathy.melvin@fda.hhs.gov Han, Tao 1; Email Address: tao.han@fda.hhs.gov Desai, Varsha G 1; Email Address: varsha.desai@fda.hhs.gov Moland, Carrie L 1; Email Address: carrie.moland@fda.hhs.gov Scully, Adam T 3; Email Address: adam.scully@fda.hhs.gov Fuscoe, James C 1; Email Address: james.fuscoe@fda.hhs.gov; Affiliation: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U. S. Food and Drug Administration, 3900 NCTR Road, HFT-130, Jefferson, Arkansas 72079, USA 2: Arkansas Regional Laboratory, Office of Regulatory Affairs, U. S. Food and Drug Administration, 3900 NCTR Road, SWR-570, Jefferson, Arkansas 72079, USA 3: Facilities Design and Construction, National Center for Toxicological Research, U. S. Food and Drug Administration, 3900 NCTR Road, HFT-130, Jefferson, Arkansas 72079, USA; Source Info: 2007, Vol. 7, p8; Subject Term: GENE expression; Subject Term: DNA microarrays; Subject Term: DNA; Subject Term: DYES & dyeing; Subject Term: OZONE; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1186/1472-6750-7-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thompson, Karol L.
AU - Pine, P. Scott
AU - Rosenzweig, Barry A.
AU - Turpaz, Yaron
AU - Retief, Jacques
T1 - Characterization of the effect of sample quality on high density oligonucleotide microarray data using progressively degraded rat liver RNA.
JO - BMC Biotechnology
JF - BMC Biotechnology
Y1 - 2007/01//
VL - 7
M3 - Article
SP - 57
EP - 68
PB - BioMed Central
SN - 14726750
AB - Background: The interpretability of microarray data can be affected by sample quality. To systematically explore how RNA quality affects microarray assay performance, a set of rat liver RNA samples with a progressive change in RNA integrity was generated by thawing frozen tissue or by ex vivo incubation of fresh tissue over a time course. Results: Incubation of tissue at 37°C for several hours had little effect on RNA integrity, but did induce changes in the transcript levels of stress response genes and immune cell markers. In contrast, thawing of tissue led to a rapid loss of RNA integrity. Probe sets identified as most sensitive to RNA degradation tended to be located more than 1000 nucleotides upstream of their transcription termini, similar to the positioning of control probe sets used to assess sample quality on Affymetrix GeneChip® arrays. Samples with RNA integrity numbers less than or equal to 7 showed a significant increase in false positives relative to undegraded liver RNA and a reduction in the detection of true positives among probe sets most sensitive to sample integrity for in silico modeled changes of 1.5-, 2-, and 4-fold. Conclusion: Although moderate levels of RNA degradation are tolerated by microarrays with 3′-biased probe selection designs, in this study we identify a threshold beyond which decreased specificity and sensitivity can be observed that closely correlates with average target length. These results highlight the value of annotating microarray data with metrics that capture important aspects of sample quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Biotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - RNA
KW - TISSUES
KW - GENES
KW - GENETIC transcription
KW - PROTEIN folding
N1 - Accession Number: 34920347; Thompson, Karol L. 1 Pine, P. Scott 1 Rosenzweig, Barry A. 1 Turpaz, Yaron 2 Retief, Jacques 2,3; Affiliation: 1: Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA 2: Affymetrix Inc., Santa Clara, CA, USA 3: Illumina Inc., San Diego, CA, USA; Source Info: 2007, Vol. 7, p57; Subject Term: DNA microarrays; Subject Term: RNA; Subject Term: TISSUES; Subject Term: GENES; Subject Term: GENETIC transcription; Subject Term: PROTEIN folding; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 12p; Document Type: Article
L3 - 10.1186/1472-6750-7-57
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Northey, Gemma
AU - Evans, Meirion R.
AU - Sarvotham, Tinnu S.
AU - Thomas, Daniel R.
AU - Howard, Tony J.
T1 - Sentinel surveillance for travellers' diarrhoea in primary care.
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
Y1 - 2007/01//
VL - 7
IS - 1
M3 - Article
SP - 126
EP - 4
PB - BioMed Central
SN - 14712334
AB - Background: Travellers' diarrhoea is the most common health problem among international travellers and much of the burden falls on general practitioners. We assessed whether sentinel surveillance based in primary care could be used to monitor changes in the epidemiology of travellers' diarrhoea. Methods: A sentinel surveillance scheme of 30 volunteer general practices distributed throughout Wales provides weekly reports of consultations for eight infectious diseases to the national Communicable Disease Surveillance Centre. Travellers' diarrhoea was introduced as a new reportable infection in July 2002. Results: Between 1 July 2002 and 31 March 2005 there were 90 reports of travellers' diarrhoea. The mean annual consultation rate was 15.2 per 100,000 population (95% confidence interval: 12.2-18.7), with the highest rates in summer, in people aged 15-24 years, and in travellers to Southern Europe. A higher proportion of travellers than expected had visited destinations outside Europe and North America when compared to the proportion of all United Kingdom travellers visiting these destinations (38% vs. 11%; Chi2 = 53.3, p < 0.0001). Conclusion: Sentinel surveillance has the potential to monitor secular trends in travellers' diarrhoea and to help characterise population groups or travel destinations associated with higher risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Infectious Diseases is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIARRHEA
KW - TRAVEL -- Health aspects
KW - PUBLIC health surveillance
KW - EPIDEMIOLOGY
KW - EUROPE, Southern
N1 - Accession Number: 28796519; Northey, Gemma 1; Email Address: gemma.northey@nphs.wales.nhs.uk Evans, Meirion R. 1,2; Email Address: meirion.evans@nphs.wales.nhs.uk Sarvotham, Tinnu S. 3; Email Address: t.s.sarvotham@swansea.ac.uk Thomas, Daniel R. 2; Email Address: daniel.thomas@nphs.wales.nhs.uk Howard, Tony J. 2; Email Address: tony.howard@nphs.wales.nhs.uk; Affiliation: 1: School of Medicine, Cardiff University, Temple of Peace and Health, Cathays Park, Cardiff, UK 2: National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, UK 3: School of Medicine, Grove Building, University of Wales Swansea, Singleton Park, Swansea, UK; Source Info: 2007, Vol. 7 Issue 1, p126; Subject Term: DIARRHEA; Subject Term: TRAVEL -- Health aspects; Subject Term: PUBLIC health surveillance; Subject Term: EPIDEMIOLOGY; Subject Term: EUROPE, Southern; Number of Pages: 4p; Document Type: Article
L3 - 10.1186/1471-2334-7-126
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bi, Lilia L.
AU - Pan, George
AU - Atkinson, T. Prescott
AU - Lixin Zheng
AU - Dale, Janet K.
AU - Makris, Christopher
AU - Reddy, Vishnu
AU - McDonald, Jay M.
AU - Siegel, Richard M.
AU - Puck, Jennifer M.
AU - Lenardo, Michael J.
AU - Straus, Stephen E.
T1 - Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib.
JO - BMC Medical Genetics
JF - BMC Medical Genetics
Y1 - 2007/01//
VL - 8
M3 - Article
SP - 41
EP - 14
PB - BioMed Central
SN - 14712350
AB - Background: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance due primarily to genetic defects in Fas (CD95/APO-1; TNFRSF6), a cell surface receptor that regulates apoptosis and its signaling apparatus. Methods: Fas ligand gene mutations from ALPS patients were identified through cDNA and genomic DNA sequencing. Molecular and biochemical assessment of these mutant Fas ligand proteins were carried out by expressing the mutant FasL cDNA in mammalian cells and analysis its effects on Fas-mediated programmed cell death. Results: We found an ALPS patient that harbored a heterozygous A530G mutation in the FasL gene that replaced Arg with Gly at position 156 in the protein's extracellular Fas-binding region. This produced a dominant-interfering FasL protein that bound to the wild-type FasL protein and prevented it from effectively inducing apoptosis. Conclusion: Our data explain how a naturally occurring heterozygous human FasL mutation can dominantly interfere with normal FasL apoptotic function and lead to an ALPS phenotype, designated Type Ib. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Medical Genetics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LYMPHOPROLIFERATIVE disorders
KW - HOMEOSTASIS
KW - ANTISENSE DNA
KW - APOPTOSIS
KW - CELL death
KW - MUTATION (Biology)
N1 - Accession Number: 29404460; Bi, Lilia L. 1; Email Address: bi@cber.fda.gov Pan, George 2; Email Address: gpan@uab.edu Atkinson, T. Prescott 3; Email Address: PAtkinson@peds.uab.edu Lixin Zheng 4; Email Address: LZHENG@niaid.nih.gov Dale, Janet K. 5; Email Address: JDALE@niaid.nih.gov Makris, Christopher 3; Email Address: cmakris@uab.edu Reddy, Vishnu 2; Email Address: vreddy@uab.edu McDonald, Jay M. 2,6; Email Address: mcdonald@uab.edu Siegel, Richard M. 7; Email Address: SiegelR@mail.nih.gov Puck, Jennifer M. 8; Email Address: puckj@peds.ucsf.edu Lenardo, Michael J. 4; Email Address: lenardo@nih.gov Straus, Stephen E. 5; Email Address: LZHENG@niaid.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA 2: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA 3: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA 4: Laboratory of Immunology, NIAID, NIH, Bethesda, MD 20892, USA 5: Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA 6: The Birmingham Veteran's Administration Medical Center, Birmingham, Alabama, USA 7: Autoimmunity Branch, NIAMS, NIH, Bethesda, MD 20892, USA 8: Department of Pediatrics, University of California, San Francisco, USA; Source Info: 2007, Vol. 8, p41; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: HOMEOSTASIS; Subject Term: ANTISENSE DNA; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: MUTATION (Biology); Number of Pages: 14p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1186/1471-2350-8-41
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eltayeb, Shahla
AU - Staal, J. Bart
AU - Kennes, Janneke
AU - Lamberts, Petra H. G.
AU - de Bie, Rob A.
T1 - Prevalence of complaints of arm, neck and shoulder among computer office workers and psychometric evaluation of a risk factor questionnaire.
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
Y1 - 2007/01//
VL - 8
M3 - Article
SP - 68
EP - 11
PB - BioMed Central
SN - 14712474
AB - Background: Complaints of Arm Neck and Shoulder (CANS) represent a wide range of complaints, which can differ in severity from mild, periodic symptoms to severe, chronic and debilitating conditions. They are thought to be associated with both physical and psychosocial risk factors. The measurement and identification of the various risk factors for these complaints is an important step towards recognizing (a) high risk subgroups that are relevant in profiling CANS; and (b) also for developing targeted and effective intervention plans for treatment. The purpose of the present study was to investigate the prevalence of CANS in a Dutch population of computer workers and to develop a questionnaire aimed at measuring workplace physical and psychosocial risk factors for the presence of these complaints. Methods: To examine potential workplace risk factors for the presence of CANS, the Maastricht Upper Extremity Questionnaire (MUEQ), a structured questionnaire, was developed and tested among 264 computer office workers of a branch office of the national social security institution in the Netherlands. The MUEQ holds 95 items covering demographic characteristics, in addition to seven main domains assessing potential risk factors with regard to (1) work station, (2) posture during work, (3) quality of break time, (4) job demands, (5) job control, and (6) social support. The MUEQ further contained some additional questions about the quality of the work environment and the presence of complaints in the neck, shoulder, upper and lower arm, elbow, hand and wrist. The prevalence rates of CANS in the past year were computed. Further, we investigated the psychometric properties of the MUEQ (i.e. factor structure and reliability). Results: The one-year prevalence rate of CANS indicated that 54% of the respondents reported at least one complaint in the arm, neck and/or shoulder. The highest prevalence rates were found for neck and shoulder symptoms (33% and 31% respectively), followed by hand and upper arm complaints (11% to 12%) and elbow, lower arm and wrist complaints (6% to 7%). The psychometric properties of the MUEQ were assessed using exploratory factor analysis which resulted in the identification of 12 factors. The calculation of internal consistency and cross validation provided evidence of reliability and lack of redundancy of items. Conclusion: Neck and shoulder complaints are more frequently reported among Dutch computer workers than arm, elbow and hand complaints. The results further indicate that the MUEQ has satisfactory reliability and internal consistency when used to document CANS among computer workers in the Netherlands. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Musculoskeletal Disorders is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NECK pain
KW - BRACHIALGIA
KW - SHOULDER pain
KW - MEDICAL research
KW - INDUSTRIAL hygiene
KW - NETHERLANDS
N1 - Accession Number: 29438234; Eltayeb, Shahla 1,2; Email Address: s_eltyeb@hotmail.com Staal, J. Bart 1; Email Address: Bart.Staal@EPID.unimaas.nl Kennes, Janneke 3; Email Address: jannekekennes@gmail.com Lamberts, Petra H. G. 4; Email Address: Petra.Lamberts@ggdzl.nl de Bie, Rob A. 1; Email Address: RA.deBie@EPID.unimaas.nl; Affiliation: 1: Maastricht University, Department of Epidemiology, Caphri Research Institute, Maastricht, The Netherlands 2: Ahfad University for Women, School of Psychology and Preschool Education, Omdurman, Sudan 3: Lievensberg Hospital, Emergency Department, Bergen op Zoom, The Netherlands 4: Public Health Service South Limburg, Geleen, The Netherlands; Source Info: 2007, Vol. 8, p68; Subject Term: NECK pain; Subject Term: BRACHIALGIA; Subject Term: SHOULDER pain; Subject Term: MEDICAL research; Subject Term: INDUSTRIAL hygiene; Subject Term: NETHERLANDS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Illustrations: 7 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1471-2474-8-68
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Derek R.
AU - Leggat, Peter A.
T1 - An international review of tobacco smoking in the medical profession: 1974-2004.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2007/01//
VL - 7
IS - 1
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712458
AB - Background: Tobacco smoking by physicians represents a contentious issue in public health, and regardless of what country it originates from, the need for accurate, historical data is paramount. As such, this article provides an international comparison of all modern literature describing the tobacco smoking habits of contemporary physicians. Methods: A keyword search of appropriate MeSH terms was initially undertaken to identify relevant material, after which the reference lists of manuscripts were also examined to locate further publications. Results: A total of 81 English-language studies published in the past 30 years met the inclusion criteria. Two distinct trends were evident. Firstly, most developed countries have shown a steady decline in physicians' smoking rates during recent years. On the other hand, physicians in some developed countries and newly-developing regions still appear to be smoking at high rates. The lowest smoking prevalence rates were consistently documented in the United States, Australia and the United Kingdom. Comparison with other health professionals suggests that fewer physicians smoke when compared to nurses, and sometimes less often than dentists. Conclusion: Overall, this review suggests that while physicians' smoking habits appear to vary from region to region, they are not uniformly low when viewed from an international perspective. It is important that smoking in the medical profession declines in future years, so that physicians can remain at the forefront of anti-smoking programs and lead the way as public health exemplars in the 21st century. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - MEDICINE
KW - ANTISMOKING movement
KW - PUBLIC health
KW - DEVELOPED countries
N1 - Accession Number: 29362000; Smith, Derek R. 1,2; Email Address: smith@h.jniosh.go.jp Leggat, Peter A. 2; Email Address: Peter.Leggat@jcu.edu.au; Affiliation: 1: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan. 2: Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Australia.; Source Info: 2007, Vol. 7 Issue 1, p1; Subject Term: SMOKING; Subject Term: MEDICINE; Subject Term: ANTISMOKING movement; Subject Term: PUBLIC health; Subject Term: DEVELOPED countries; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1186/1471-2458-7-115
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grote, Floor K.
AU - Oostdijk, Wilma
AU - Keizer-Schrama, Sabine M. P. F. De Muinck
AU - Dekker, Friedo W.
AU - van Dommelen, Paula
AU - van Buuren, ,1Stef
AU - Lodder-van der Kooij, Adry M.
AU - Verkerk, Paul H.
AU - Wit, Jan Maarten
T1 - Referral patterns of children with poor growth in primary health care.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2007/01//
VL - 7
IS - 1
M3 - Article
SP - 77
EP - 7
PB - BioMed Central
SN - 14712458
AB - Background: To promote early diagnosis and treatment of short stature, consensus meetings were held in the mid nineteen nineties in the Netherlands and the UK. This resulted in guidelines for referral. In this study we evaluate the referral pattern of short stature in primary health care using these guidelines, comparing it with cut-off values mentioned by the WHO. Methods: Three sets of referral rules were tested on the growth data of a random sample (n = 400) of all children born between 01-01-1985 and 31-12-1988, attending school doctors between 1998 and 2000 in Leiden and Alphen aan den Rijn (the Netherlands): the screening criteria mentioned in the Dutch Consensus Guideline (DCG), those of the UK Consensus Guideline (UKCG) and the cut-off values mentioned in the WHO Global Database on Child growth and Malnutrition. Results: Application of the DCG would lead to the referral of too many children (almost 80%). The largest part of the referrals is due to the deflection of height, followed by distance to target height and takes primarily place during the first 3 years. The deflection away from the parental height would also lead to too many referrals. In contrast, the UKCG only leads to 0.3% referrals and the WHO-criteria to approximately 10%. Conclusion: The current Dutch consensus guideline leads to too many referrals, mainly due to the deflection of length during the first 3 years of life. The UKCG leads to far less referrals, but may be relatively insensitive to detect clinically relevant growth disorders like Turner syndrome. New guidelines for growth monitoring are needed, which combine a low percentage of false positive results with a good sensitivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY health care
KW - GROWTH disorders
KW - CHILDREN -- Growth
KW - NETHERLANDS
KW - GREAT Britain
N1 - Accession Number: 29361966; Grote, Floor K. 1; Email Address: f.k.grote@lumc.nl Oostdijk, Wilma 1; Email Address: w.oostdijk@lumc.nl Keizer-Schrama, Sabine M. P. F. De Muinck 2; Email Address: s.demuinckkeizerschrama@erasmusmc.nl Dekker, Friedo W. 3; Email Address: f.w.dekker@lumc.nl van Dommelen, Paula 4; Email Address: p.vanDommelen@pg.tno.nl van Buuren, ,1Stef 4,5; Email Address: s.vanbuuren@pg.tno.nl Lodder-van der Kooij, Adry M. 6; Email Address: ALodder@ggdhm.nl Verkerk, Paul H. 7; Email Address: ph.verkerk@pg.tno.nl Wit, Jan Maarten 1; Email Address: j.m.wit@lumc.nl; Affiliation: 1: Dept. of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands. 2: Dept. of Paediatrics, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. 3: Dept of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. 4: Dept. of Statistics, TNO Quality of life, Leiden, The Netherlands. 5: Dept. of Methodology & Statistics, University of Utrecht, The Netherlands. 6: Dept. Child Health Care, Regional Public Health Service Hollands Midden, Leiden, The Netherlands. 7: Dept. of Child Health, TNO Quality of life, Leiden, The Netherlands.; Source Info: 2007, Vol. 7 Issue 1, p77; Subject Term: PRIMARY health care; Subject Term: GROWTH disorders; Subject Term: CHILDREN -- Growth; Subject Term: NETHERLANDS; Subject Term: GREAT Britain; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1186/1471-2458-7-77
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolfers, Mireille E. G.
AU - van den Hoek, Caty
AU - Brug, Johannes
AU - de Zwart, Onno
T1 - Using Intervention Mapping to develop a programme to prevent sexually transmittable infections, including HIV, among heterosexual migrant men.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2007/01//
VL - 7
IS - 1
M3 - Article
SP - 141
EP - 12
PB - BioMed Central
SN - 14712458
AB - Background: There is little experience with carefully developed interventions in the HIV/STI prevention field aimed at adult heterosexual target groups in the Netherlands. The ability to apply intervention development protocols, like Intervention Mapping, in daily practice outside of academia, is a matter of concern. An urgent need also exists for interventions aimed at the prevention of STI in migrant populations in the Netherlands. This article describes the theory and evidence based development of HIV/STI prevention interventions by the Municipal Public Health Service Rotterdam Area (MPHS), the Netherlands, for heterosexual migrant men with Surinamese, Dutch-Caribbean, Cape Verdean, Turkish and Moroccan backgrounds. Methods: First a needs assessment was carried out. Then, a literature review was done, key figures were interviewed and seven group discussions were held. Subsequently, the results were translated into specific objectives ("change objectives") and used in intervention development for two subgroups: men with an Afro-Caribbean background and unmarried men with a Turkish and Moroccan background. A matrix of change objectives was made for each subgroup and suitable theoretical methods and practical strategies were selected. Culturally-tailored interventions were designed and were pre-tested among the target groups. Results: This development process resulted in two interventions for specific subgroups that were appreciated by both the target groups and the migrant prevention workers. The project took place in collaboration with a university center, which provided an opportunity to get expert advice at every step of the Intervention Mapping process. At relevant points of the development process, migrant health educators and target group members provided advice and feedback on the draft intervention materials. Conclusion: This intervention development project indicates that careful well-informed intervention development using Intervention Mapping is feasible in the daily practice of the MPHS, provided that sufficient time and expertise on this approach is available. Further research should test the effectiveness of these interventions. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUALLY transmitted diseases
KW - AIDS (Disease) -- Prevention
KW - HETEROSEXUALS
KW - HIV infections
KW - NETHERLANDS
N1 - Accession Number: 29362021; Wolfers, Mireille E. G. 1,2; Email Address: wolfersm@ggd.rotterdam.nl van den Hoek, Caty 1; Email Address: vandenhoekk@ggd.rotterdam.nl Brug, Johannes 2; Email Address: j.brug@vumc.nl de Zwart, Onno 1,2; Email Address: dezwarto@ggd.rotterdam.nl; Affiliation: 1: Municipal Public Health Service Rotterdam Area, Rotterdam, the Netherlands. 2: Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.; Source Info: 2007, Vol. 7 Issue 1, p141; Subject Term: SEXUALLY transmitted diseases; Subject Term: AIDS (Disease) -- Prevention; Subject Term: HETEROSEXUALS; Subject Term: HIV infections; Subject Term: NETHERLANDS; Number of Pages: 12p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1186/1471-2458-7-141
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adjei, Michael D.
AU - Heinze, Thomas M.
AU - Deck, Joanna
AU - Freeman, James P.
AU - Williams, Anna J.
AU - Sutherland, John B.
T1 - Acetylation and nitrosation of ciprofloxacin by environmental strains of mycobacteria.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2007/01//
VL - 53
IS - 1
M3 - Article
SP - 144
EP - 147
PB - Canadian Science Publishing
SN - 00084166
AB - To determine the ability of environmental bacteria to metabolize the frequently prescribed fluoroquinolone drug ciprofloxacin, eight Mycobacterium spp. cultures were grown for 4 days in a medium containing sorbitol and yeast extract with 100 mg·L–1 ciprofloxacin. After the cultures had been centrifuged and the supernatants extracted with ethyl acetate, two metabolites were purified by using high-performance liquid chromatography. They were identified with liquid chromatography/electrospray ionization mass spectrometry and proton nuclear magnetic resonance spectroscopy. Ciprofloxacin was transformed to both N-acetylciprofloxacin (2.5%–5.5% of the total peak area at 280 nm) and N-nitrosociprofloxacin (6.0%–8.0% of the peak area) by Mycobacterium gilvum PYR-GCK and Mycobacterium sp. PYR100 but it was transformed only to N-acetylciprofloxacin by Mycobacterium frederiksbergense FAn9, M. gilvum ATCC 43909, M. gilvum BB1, Mycobacterium smegmatis mc2155, Mycobacterium sp. 7E1B1W, and Mycobacterium sp. RJGII-135. The results suggest that biotransformation may serve as a ciprofloxacin resistance mechanism for these bacteria. (English) [ABSTRACT FROM AUTHOR]
AB - Afin d'évaluer la capacité qu'ont les bactéries de l'environnement de métaboliser le ciprofloxacin, une fluoroquinolone fréquemment prescrite, huit cultures de Mycobacterium spp. ont été incubées pendant 4 jours dans du milieu contenant du sorbitol, de l'extrait de levure et 100 mg·L–1 de ciprofloxacin. Après avoir centrifugé les cultures et extrait les surnageants avec de l'acétate d'éthyle, deux métabolites ont été purifiés par chromatographie liquide à haute performance. Ils ont été identifiés par chromatographie liquide couplée à la spectrométrie de masse par ionisation en mode électrospray et par spectroscopie par résonnance magnétique nucléaire à protons. Le ciprofloxacin était transformé en N-acétylciprofloxacin (2,5 % à 5,5 % du pic total à 280 nm) et en N-nitrosociprofloxacin (6,0 % à 8,0 % du pic) par Mycobacterium gilvum PYR-GCK et Mycobacterium sp. PYR100, mais était transformé seulement en N-acétylciprofloxacin par Mycobacterium frederiksbergense FAn9, M. gilvum ATCC 43909, M. gilvum BB1, Mycobacterium smegmatis mc2155, Mycobacterium sp. 7E1B1W et Mycobacterium sp. RJGII-135. Ces résultats suggèrent que la biotransformation pourrait servir de mécanisme de résistance au ciprofloxacin chez ces bactéries. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CIPROFLOXACIN
KW - MYCOBACTERIUM
KW - SORBITOL
KW - ETHYL acetoacetate
KW - FUNGUS-bacterium relationships
KW - ACTINOMYCETALES
KW - acetylation
KW - ciprofloxacin
KW - fluoroquinolones
KW - Mycobacterium
KW - nitrosation
KW - acétylation
KW - acétylation
KW - ciprofloxacin
KW - fluoroquinolones
KW - Mycobacterium
KW - nitrosation
N1 - Accession Number: 25437180; Adjei, Michael D. 1 Heinze, Thomas M. 1 Deck, Joanna 1 Freeman, James P. 1 Williams, Anna J. 1 Sutherland, John B. 1; Email Address: john.sutherland@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Jan2007, Vol. 53 Issue 1, p144; Subject Term: CIPROFLOXACIN; Subject Term: MYCOBACTERIUM; Subject Term: SORBITOL; Subject Term: ETHYL acetoacetate; Subject Term: FUNGUS-bacterium relationships; Subject Term: ACTINOMYCETALES; Author-Supplied Keyword: acetylation; Author-Supplied Keyword: ciprofloxacin; Author-Supplied Keyword: fluoroquinolones; Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: nitrosation; Author-Supplied Keyword: acétylation; Author-Supplied Keyword: acétylation; Author-Supplied Keyword: ciprofloxacin; Author-Supplied Keyword: fluoroquinolones; Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: nitrosation; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1139/W06-101
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Shahverdi, Ahmad R.
T1 - Comparison of Essential Oils from Three Plants for Enhancement of Antimicrobial Activity of Nitrofurantoin against Enterobacteria.
JO - Chemotherapy (0009-3157)
JF - Chemotherapy (0009-3157)
Y1 - 2007/01//
VL - 53
IS - 1
M3 - Article
SP - 21
EP - 25
SN - 00093157
AB - Background: Piperitone from plant essential oils enhancesbactericidal activities of nitrofurantoin and furazolidone against bacteria from the family Enterobacteriaceae. In this study, the essential oils of spearmint (Mentha spicata L.), dill (Anethum graveolens L.) and peppermint (Mentha piperita L.)were screened for augmentation of nitrofurantoin activity and the most active components were determined. Method: The effects of essential oils and their components on the bactericidal activity of nitrofurantoin against Enterobacter cloacae were studied using disk-diffusion and agar-dilution methods. The composition of essential oils was studied using gas chromatography-mass spectrometry. Results:M. spicata and A. graveolens oils exhibited the highest effects. Gas chromatography-mass spectrometry analysis showed that the oils of these two plants contained 40.12 and 20.32% carvone, respectively. Pure carvone and piperitone equally increased the bactericidal activity of nitrofurantoin. Other ingredients of essential oils, including camphor, limonene and menthone, were less effective. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemotherapy (0009-3157) is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESSENCES & essential oils
KW - ANTI-infective agents
KW - ENTEROBACTERIACEAE
KW - MONOTERPENES
KW - TERPENES
KW - Carvone
KW - Enterobacteria
KW - Essential oils
KW - Monoterpenes
KW - Nitrofurantoin
KW - Piperitone
N1 - Accession Number: 23711837; Rafii, Fatemeh 1 Shahverdi, Ahmad R. 2; Email Address: shahverd@sina.tums.ac.ir; Affiliation: 1: National Center for Toxicological Research, US FDA, Jefferson, Ariz., USA 2: Department of Pharmaceutical Biotechnology, Tehran Medical Sciences University, Tehran, Iran; Source Info: 2007, Vol. 53 Issue 1, p21; Subject Term: ESSENCES & essential oils; Subject Term: ANTI-infective agents; Subject Term: ENTEROBACTERIACEAE; Subject Term: MONOTERPENES; Subject Term: TERPENES; Author-Supplied Keyword: Carvone; Author-Supplied Keyword: Enterobacteria; Author-Supplied Keyword: Essential oils; Author-Supplied Keyword: Monoterpenes; Author-Supplied Keyword: Nitrofurantoin; Author-Supplied Keyword: Piperitone; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1159/000098246
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Higuchi, Shigekazu
AU - Motohashi, Yutaka
AU - Ishibashi, Keita
AU - Maeda, Takafumi
T1 - Less Exposure to Daily Ambient Light in Winter Increases Sensitivity of Melatonin to Light Suppression.
JO - Chronobiology International: The Journal of Biological & Medical Rhythm Research
JF - Chronobiology International: The Journal of Biological & Medical Rhythm Research
Y1 - 2007/01//
VL - 24
IS - 1
M3 - Article
SP - 31
EP - 43
SN - 07420528
AB - This study was carried out to examine the seasonal difference in the magnitude of the suppression of melatonin secretion induced by exposure to light in the late evening. The study was carried out in Akita (39° North, 140° East), in the northern part of Japan, where the duration of sunshine in winter is the shortest. Ten healthy male university students (mean age: 21.9±1.2 yrs) volunteered to participate twice in the study in winter (from January to February) and summer (from June to July) 2004. According to Japanese meteorological data, the duration of sunshine in Akita in the winter (50.5 h/month) is approximately one-third of that in summer (159.7 h/month). Beginning one week prior to the start of the experiment, the level of daily ambient light to which each subject was exposed was recorded every minute using a small light sensor that was attached to the subject's wrist. In the first experiment, saliva samples were collected every hour over a period of 24 h in a dark experimental room (<15 lux) to determine peak salivary melatonin concentration. The second experiment was conducted after the first experiment to determine the percentage of melatonin suppression induced by exposure to light. The starting time of exposure to light was set 2 h before the time of peak salivary melatonin concentration detected in the first experiment. The subjects were exposed to light (1000 lux) for 2 h using white fluorescent lamps (4200 K). The percentage of suppression of melatonin by light was calculated on the basis of the melatonin concentration determined before the start of exposure to light. The percentage of suppression of melatonin 2 h after the start of exposure to light was significantly greater in winter (66.6±18.4%) than summer (37.2±33.2%), p<0.01). The integrated level of daily ambient light from rising time to bedtime in summer was approximately twice that in winter. The results suggest that the increase in suppression of melatonin by light in winter is caused by less exposure to daily ambient light. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chronobiology International: The Journal of Biological & Medical Rhythm Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELATONIN
KW - LIGHT -- Physiological effect
KW - ADAPTATION (Physiology)
KW - MEDICAL climatology
KW - CIRCADIAN rhythms
KW - SEASONAL variations of diseases
KW - BIOLOGICAL rhythms
KW - LIGHT
KW - PHOTOPERIODISM
KW - PHYSIOLOGICAL aspects
KW - Adaptation
KW - Circadian rhythm
KW - Melatonin suppression
KW - Melatonin suppression, Seasonal variation, Circadian rhythm, Photoperiod, Adaptation
KW - Photoperiod
KW - Seasonal variation
N1 - Accession Number: 23893884; Higuchi, Shigekazu 1; Email Address: higuchi@h.jniosh.go.jp Motohashi, Yutaka 2 Ishibashi, Keita 3 Maeda, Takafumi 4; Affiliation: 1: Department of Public Health, Akita University School of Medicine. Akita. Japan,Japan National Institute of Occupational Safety and Health. Kawasaki. Japan 2: Department of Public Health, Akita University School of Medicine. Akita. Japan 3: Department of Human Living System Design, Faculty of Design, Kyushu University. Fukuoka. Japan 4: Department of Hygiene and Preventive Medicine, Fukushima Medical University School of Medicine. Fukushima. Japan; Source Info: 2007, Vol. 24 Issue 1, p31; Subject Term: MELATONIN; Subject Term: LIGHT -- Physiological effect; Subject Term: ADAPTATION (Physiology); Subject Term: MEDICAL climatology; Subject Term: CIRCADIAN rhythms; Subject Term: SEASONAL variations of diseases; Subject Term: BIOLOGICAL rhythms; Subject Term: LIGHT; Subject Term: PHOTOPERIODISM; Subject Term: PHYSIOLOGICAL aspects; Author-Supplied Keyword: Adaptation; Author-Supplied Keyword: Circadian rhythm; Author-Supplied Keyword: Melatonin suppression; Author-Supplied Keyword: Melatonin suppression, Seasonal variation, Circadian rhythm, Photoperiod, Adaptation; Author-Supplied Keyword: Photoperiod; Author-Supplied Keyword: Seasonal variation; Number of Pages: 13p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/07420520601139805
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jhee, Ok Hwa
AU - Lee, Yun Sik
AU - Shaw, Leslie M.
AU - Jeon, Yong Cheol
AU - Lee, Min Ho
AU - Lee, Seung Hoon
AU - Kang, Ju Seop
T1 - Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin™ and Polybutin™) in healthy male volunteers using the LC–MS/MS method
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 2007/01//
VL - 375
IS - 1/2
M3 - Article
SP - 69
EP - 75
SN - 00098981
AB - Abstract: Background: Trimebutine maleate is a prokinetic agent that acts directly on the smooth muscle of the GI tract. A bioequivalence (BE) study of 2 oral formulations of 100 mg trimebutine maleate (TMB) was carried out in 24 healthy male Korean volunteers according to a crossover–randomized design. Methods: Subjects were given a single dose of 2 100 mg tablets of each formulation. The test and reference formulations were Recutin™ (Hutax Co., South Korea) and Polybutin™ (Samil Co., South Korea), respectively. Each set of tablets was administered with 240 ml of water to subjects after 10 h overnight fasting on 2 treatment days separated by a 1 week washout period. After dosing, serial blood samples were collected for a period of 36 h. Plasma was analyzed for the main metabolite of TMB, N-monodesmethyl trimebutine (nor-TMB), by a validated LC with MS/MS detection capacity for nor-TMB in the range 5–1500 ng/ml, with a lower limit of quantification (LLOQ) of 5 ng/ml. Several pharmacokinetic (PK) parameters (including AUCt, AUCinfinity, C max, T max, T 1/2, and K e ) were determined from the plasma concentrations of nor-TMB of both formulations. AUCt, AUCinfinity, and C max were tested for BE after log-transformation of the data. Results: No significant difference was found based on ANOVA; 90% confidence intervals (98.98%112.03% for AUCt; 98.60%–113.20% for AUCinfinity; 90.85%–107.87% for C max) for the test and reference were found within KFDA acceptance range of 80–125%. Conclusions: Based on these statistical inferences, it was concluded that Recutin™ is bioequivalent to Polybutin™ and can be used interchangeably in a clinical setting. [Copyright &y& Elsevier]
AB - Copyright of Clinica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG metabolism
KW - CHEMICAL kinetics
KW - SMOOTH muscle
KW - STATISTICAL hypothesis testing
KW - Bioequivalence test
KW - N-monodesmethyl trimebutine
KW - Pharmacokinetics
KW - Trimebutine maleate
N1 - Accession Number: 22796596; Jhee, Ok Hwa 1 Lee, Yun Sik 2 Shaw, Leslie M. 3 Jeon, Yong Cheol 4 Lee, Min Ho 4 Lee, Seung Hoon 5 Kang, Ju Seop 1; Email Address: jskang@hanyang.ac.kr; Affiliation: 1: Department of Pharmacology & Clinical Pharmacology Lab, College of Medicine & Institute of Biomedical Science, Hanyang University, Seoul 133-791, South Korea 2: Division of Endocrinology, College of Medicine, University of Pennsylvania, PA 19104, USA 3: Department of Pathology & Lab Medicine, College of Medicine, University of Pennsylvania, PA 19104, USA 4: Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 133, 791, South Korea 5: Biologics Team, Biologics Headquarters, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Jan2007, Vol. 375 Issue 1/2, p69; Subject Term: DRUG metabolism; Subject Term: CHEMICAL kinetics; Subject Term: SMOOTH muscle; Subject Term: STATISTICAL hypothesis testing; Author-Supplied Keyword: Bioequivalence test; Author-Supplied Keyword: N-monodesmethyl trimebutine; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Trimebutine maleate; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.cca.2006.06.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Cheever, LW;
AU - Lubinski, C;
AU - Horberg, M;
AU - Steinberg, JL;
T1 - Ensuring access to treatment for HIV infection
CT - Ensuring access to treatment for HIV infection
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/01/01/
VL - 45
IS - DEC 15
SP - S266
EP - S274
SN - 10584838
AD - Reprints: HIV AIDS Bur, US Hlth Resources & Serv Adm, Ste 7-05, 5600 Fishers Ln, Rockville, MD 20857, USA Lcheever@hrsa.gov
AD - HIV AIDS Bur, US Hlth Resources & Serv Adm, Rockville, MD 20857, USA
N1 - Accession Number: 45-06997; Language: English; References: 19; Publication Type: Proceedings; Journal Coden: CINFDE; Human Indicator: Yes; Section Heading: Pharmacology; Sociology, Economics and Ethics
N2 - The recent recommendations of the Centers for Disease Control and Prevention for opt-out testing are intended to address the evolving human immunodeficiency virus (HIV) epidemic in the United States by bringing more HIV-infected individuals into medical care. This is an important step to better control the epidemic but brings with it the challenges of adequately caring for more individuals infected with HIV and of funding medications and medical care for these additional patients. With more patients being offered HIV testing, there will be a surge in the need for testing and counseling services, which must keep pace with patient demand. This article describes the current status of HIV screening and care from 4 perspectives: the Ryan White Program (previously known as the Ryan White Comprehensive AIDS Resources Emergency Act), Medicaid and Medicare reimbursement for HIV screening, a managed care organization, and community health centers. The mandate for routine HIV screening challenges each of these health care entities, but all will need to overcome these challenges if routine HIV screening is to become a reality.
KW - Managed care systems--reimbursement;
KW - Health benefit programs--medicare;
KW - Health benefit programs--medicaid;
KW - Centers for Disease Control and Prevention--guidelines;
KW - HIV infections--prophylaxis;
KW - Interventions--HIV infections;
KW - Antiretroviral agents--HIV infections;
KW - Diagnosis--HIV infections;
KW - Reimbursement--managed care systems;
KW - Guidelines--centers for disease control and prevention;
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DP - EBSCOhost
DB - ipa
ER -
TY - CONF
AU - Dalsey, Elizabeth
AU - Park, Hee Sun
T1 - Implication of Organizational Health Policy on Organizational Attractiveness.
JO - Conference Papers -- International Communication Association
JF - Conference Papers -- International Communication Association
Y1 - 2007///2007 Annual Meeting
M3 - Conference Paper
SP - 1
EP - 37
PB - International Communication Association
AB - The current study investigated job applicants' reactions to an organization implementing a policy which either mandated or recommended that employees quit smoking. Undergraduate participants (N = 296) were randomly assigned to one of 2 (high versus low employment severity) × 2 (high versus low organizational assistance) conditions and indicated their attraction to an hypothetical organization, posing as job applicants. The findings showed that attraction toward the organization was not affected by the level of severity that the nonsmoking policy would have on one's employment. On the other hand, the amount of the organization's assistance had a main effect on attraction toward the organization. These and other findings are presented in detail, and the implications thereof are discussed. ..PAT.-Unpublished Manuscript [ABSTRACT FROM AUTHOR]
AB - Copyright of Conference Papers -- International Communication Association is the property of International Communication Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cigarette smokers -- Employment
KW - Antismoking movement
KW - Smoking cessation
KW - Employee rules
KW - Organizational ideology
KW - Work environment
KW - Industrial hygiene
KW - non-smoking policy
KW - organizational attractiveness
N1 - Accession Number: 26950326; Dalsey, Elizabeth 1; Email Address: fof2@cdc.gov; Park, Hee Sun 2; Email Address: heesun@msu.edu; Affiliations: 1: National Institute for Occupational Safety and Health; 2: Michigan State U; Issue Info: 2007 Annual Meeting, p1; Subject Term: Cigarette smokers -- Employment; Subject Term: Antismoking movement; Subject Term: Smoking cessation; Subject Term: Employee rules; Subject Term: Organizational ideology; Subject Term: Work environment; Subject Term: Industrial hygiene; Author-Supplied Keyword: non-smoking policy; Author-Supplied Keyword: organizational attractiveness; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 37p; Document Type: Conference Paper
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DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Atenstaedt, Robert L.
AU - Payne, Sandra
AU - Roberts, Richard
AU - Russell, Ian
AU - Russell, Daphne
AU - Edwards, Rhiannon Tudor
T1 - Reconciling competing priorities in commissioning: the future of bone densitometry service for North Wales.
JO - Cost Effectiveness & Resource Allocation
JF - Cost Effectiveness & Resource Allocation
Y1 - 2007/01//
VL - 5
M3 - Article
SP - 1
EP - 8
SN - 14787547
AB - Background: Osteoporosis creates brittle bones susceptible to fracture, with resulting high levels of morbidity and mortality. Poor access to bone densitometry services for the residents of North Wales led to the Welsh Assembly Government offering capital to purchase a dual-energy X-ray absorptiometry (DXA) scanner, used to diagnose osteoporosis, for the region. The commissioning question for the six Local Health Boards across North Wales was where to site the new scanner. This decision needed to reflect current inequalities in access to services and concerns over inappropriate prescribing relative to Welsh norms. Methods: Epidemiological, corporate and comparative healthcare needs assessments were performed. In addition, two cross-sectional surveys were conducted to determine the views of general practices and users of bone densitometry services resident in North Wales. An option appraisal and sensitivity analysis of 13 costed options for DXA scanning was conducted. Results: We estimated that only 31% of the people in North Wales who met national guidelines were receiving DXA scans. There was definite inequity of access to the current service provided by area of residence. There was also evidence of inequity of access by age and sex. The most suitable option identified in the option appraisal was a bone densitometry service based in the central location of Llandudno. Conclusion: The assessment identified significant unmet need for DXA scanning. A recommendation was made to improve access through the introduction of a new bone densitometry service based at Llandudno. This would double scanning provision provided and reduce travel costs and time for many North Wales residents. This recommendation was adopted by a joint commissioning group established by the six Local Health Boards in North Wales at the end of 2004 - evidence based commissioning in practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cost Effectiveness & Resource Allocation is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE densitometry
KW - OSTEOPOROSIS
KW - BONES -- Radiography
KW - MEDICAL care
KW - PUBLIC health
KW - WALES, North
N1 - Accession Number: 28742456; Atenstaedt, Robert L. 1,2; Email Address: Robert.Atenstaedt@nphs.wales.nhs.uk Payne, Sandra 1; Email Address: Sandra.Payne@nphs.wales.nhs.uk Roberts, Richard 1; Email Address: Richard.Roberts@nphs.wales.nhs.uk Russell, Ian 1,2; Email Address: Ian.Russell@bangor.ac.uk Russell, Daphne 2; Email Address: D.Russell@bangor.ac.uk Edwards, Rhiannon Tudor 1,3; Email Address: r.t.edwards@bangor.ac.uk; Affiliation: 1: National Public Health Service for Wales (North Wales Region), Mold CH7 1PZ, UK 2: Institute for Medical & Social Care Research, University of Wales, Bangor LL57 2PX, UK 3: Centre for Economics and Policy in Health, University of Wales, Bangor LL57 1UT, UK; Source Info: 2007, Vol. 5, p1; Subject Term: BONE densitometry; Subject Term: OSTEOPOROSIS; Subject Term: BONES -- Radiography; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: WALES, North; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 3 Charts, 1 Map; Document Type: Article
L3 - 10.1186/1478-7547-5-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patton, Nanette
AU - Shechet, Allan
T1 - Earned Value Management: Are Expectations Too High?
JO - CrossTalk: The Journal of Defense Software Engineering
JF - CrossTalk: The Journal of Defense Software Engineering
Y1 - 2007/01//
VL - 20
IS - 1
M3 - Article
SP - 10
EP - 15
SN - 21601577
AB - Earned Value Management Systems (EVMS) are frequently required on government Automated Information System programs. When implementing EVM, especially for the first time, agencies should train their key managers not only in the EVM process but also in the behaviors and management styles required to avoid major problems that can result from the implementation. While EVM is a useful project management tool, implementing EVM will not solve all the challenges in achieving project goals. Furthermore, given the funding and selection processes for programs, first time EVM implementation can introduce a whole new set of program management challenges. Based on their experience with information technology (IT) and aerospace projects, the authors identify potential difficulties and risk mitigation strategies to counter those potential difficulties. [ABSTRACT FROM AUTHOR]
AB - Copyright of CrossTalk: The Journal of Defense Software Engineering is the property of USAF Software Technology Support Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANAGEMENT information systems
KW - APPLICATION program interfaces (Computer software)
KW - APPLICATION software
KW - INFORMATION science
KW - DECISION support systems
KW - INFORMATION resources management
N1 - Accession Number: 23522734; Patton, Nanette 1; Email Address: nanette.patton@us.army.mil Shechet, Allan 2; Email Address: allan@savvyservices.net; Affiliation: 1: Office of the Surgeon General 2: Savvy Services Inc.; Source Info: Jan2007, Vol. 20 Issue 1, p10; Subject Term: MANAGEMENT information systems; Subject Term: APPLICATION program interfaces (Computer software); Subject Term: APPLICATION software; Subject Term: INFORMATION science; Subject Term: DECISION support systems; Subject Term: INFORMATION resources management; NAICS/Industry Codes: 511210 Software Publishers; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23522734&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2007-04209-002
AN - 2007-04209-002
AU - Wetli, Charles V.
AU - Virmani, Renu
AU - Burke, Allen P.
AU - Farb, Andrew
AU - Kolodgie, Frank D.
AU - Narula, Jagat
AU - Mullick, Florabel G.
AU - Karch, Steven B.
AU - Bell, Michael D.
ED - Wetli, Charles V.
ED - Karch, Steven B.
ED - Karch, Steven B., (Ed)
T1 - Pathology of drug abuse.
T2 - Drug abuse handbook, 2nd ed.
Y1 - 2007///
SP - 71
EP - 145
CY - Boca Raton, FL, US
PB - CRC Press
SN - 0-8493-1690-1
SN - 978-0-8493-1690-6
N1 - Accession Number: 2007-04209-002. Partial author list: First Author & Affiliation: Wetli, Charles V.; Office of the Suffolk County Medical Examiner, Hauppauge, NY, US. Release Date: 20071217. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-8493-1690-1, Hardcover; 978-0-8493-1690-6, Hardcover. Language: English. Major Descriptor: Autopsy; Drug Abuse; Drugs; Pathology; Pharmacology. Minor Descriptor: Cardiovascular Reactivity; Death and Dying; Drug Addiction; Drug Administration Methods; Toxicity; Victimization. Classification: Substance Abuse & Addiction (3233); Psychopharmacology (2580). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 75.
AB - In a very broad sense, the pathology of drug abuse is determined by the particular drug abused, and the way it is used and administered, not to mention its toxic effects and the behavioral modifications it produces. A comprehensive overview of drug abuse pathology would, therefore, include physical injuries from drunk driving and hallucinogenic drugs, a variety of communicable diseases such as viral hepatitis and AIDS acquired from needle sharing, and indirect complications of addiction, such as homicide, prostitution, child abuse and neglect. However, this section is devoted to the pathological changes resulting from the pharmacologic effects of various drugs that are abused, and from the ways that these drugs are administered. In short, we review the changes one would likely encounter at the autopsy table. A large volume of literature on drug abuse and the pathologic changes it produces has been amassed over the past three or four decades. Much of this material has recently been collected into several excellent comprehensive treatises. Instead of repeating these accomplishments, this chapter focuses on issues of pathology not adequately covered in other references, and concentrates on emerging concepts and newly discovered phenomena. Accordingly, emphasis is placed on death scene investigation, evaluation of the drug abuse victim (living or deceased), and cardiovascular pathology. In many instances, the authors have relied on their own academic and investigative experiences to provide a practical approach to evaluating these victims of drug abuse. Much of what is known about the pathology of drug abuse has been derived from thorough and carefully performed autopsies. It should therefore be expected that much of this section deals with the autopsy and will be of particular interest to pathologists. However, far from this being an academic exercise, it is hoped that the reader will discern applications to clinical situations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pathology of drug abuse
KW - drugs
KW - toxic effects
KW - complications of addiction
KW - pharmacologic effects
KW - drug administration
KW - autopsy
KW - death scene investigation
KW - victim
KW - cardiovascular pathology
KW - 2007
KW - Autopsy
KW - Drug Abuse
KW - Drugs
KW - Pathology
KW - Pharmacology
KW - Cardiovascular Reactivity
KW - Death and Dying
KW - Drug Addiction
KW - Drug Administration Methods
KW - Toxicity
KW - Victimization
KW - 2007
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2007-04209-010
AN - 2007-04209-010
AU - Caplan, Yale H.
AU - Huestis, Marilyn A.
AU - Bush, Donna M.
AU - Edgell, Kenneth C.
AU - Shults, Theodore F.
AU - Pierce, Anya
AU - Isenschmid, Daniel S.
AU - Goldberger, Bruce A.
AU - Kintz, Pascal
AU - Villain, Marion
AU - Cirimele, Vincent
AU - Cone, Edward J.
AU - Sampson-Cone, Angela
AU - Thomasino, Joseph A.
AU - Mitchell, John M.
AU - Esposito, Francis M.
ED - Caplan, Yale H.
ED - Huestis, Marilyn A.
ED - Karch, Steven B.
ED - Karch, Steven B., (Ed)
T1 - Workplace testing.
T2 - Drug abuse handbook, 2nd ed.
Y1 - 2007///
SP - 727
EP - 893
CY - Boca Raton, FL, US
PB - CRC Press
SN - 0-8493-1690-1
SN - 978-0-8493-1690-6
N1 - Accession Number: 2007-04209-010. Partial author list: First Author & Affiliation: Caplan, Yale H.; National Scientific Services, Baltimore, MD, US. Release Date: 20071217. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-8493-1690-1, Hardcover; 978-0-8493-1690-6, Hardcover. Language: English. Major Descriptor: Drug Abuse; Drug Usage Screening; Working Conditions. Minor Descriptor: Laws; Legal Processes; Organizational Behavior. Classification: Substance Abuse & Addiction (3233); Industrial & Organizational Psychology (3600). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 167.
AB - Workplace testing is employed to ensure safety and productivity in the workplace. It is complex with myriad elements vital to its success. This chapter will overview workplace drug testing including its background and current status, its regulatory basis, its application in the U.S. and abroad, analytical approaches, the use of urine and other biological matrices, quality control and validity testing, the role of the MRO, and associated legal issues. Although alcohol testing and on-site (point of collection) testing are practiced in the workplace, they are not included in this chapter; rather, they are discussed in other sections of this book. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace drug testing
KW - drug abuse
KW - background
KW - current status
KW - regulatory basis
KW - legal issues
KW - 2007
KW - Drug Abuse
KW - Drug Usage Screening
KW - Working Conditions
KW - Laws
KW - Legal Processes
KW - Organizational Behavior
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-04209-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Honein, Margaret A.
AU - Lindstrom, Jill A.
AU - Kweder, Sandra L.
T1 - Can We Ensure the Safe Use of Known Human Teratogens?: The iPLEDGEâ„¢ Test Case.
JO - Drug Safety
JF - Drug Safety
Y1 - 2007/01//
VL - 30
IS - 1
M3 - Article
SP - 5
EP - 15
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Minimising the public health burden of isotretinoin-induced teratogenicity has been a challenge for 24 years, the duration of availability of isotretinoin in the US for the treatment of severe, recalcitrant nodular acne. Although the teratogenicity of this drug is well known and risk-management programmes had been implemented, preventable fetal exposures continued to occur, largely as a result of the lack of sufficient controls within the programmes themselves. The manufacturers of isotretinoin implemented a new risk-management programme, iPLEDGE™, in March 2006. iPLEDGE™ is a comprehensive distribution system that includes mandatory registration of patients, healthcare providers, pharmacies, and wholesalers. It allows real-time linkage of pregnancy-test results for verification prior to the dispensing of isotretinoin. Although the challenges of implementing a closed distribution system for a very widely used medication have been extensive, the potential public health benefits from preventing fetal exposure to isotretinoin are substantial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOTRETINOIN
KW - TERATOGENESIS
KW - TERATOGENICITY testing
KW - ACNE -- Treatment
KW - PREGNANCY
KW - FETAL behavior
KW - THERAPEUTIC use
N1 - Accession Number: 23684652; Honein, Margaret A. 1 Lindstrom, Jill A. 2 Kweder, Sandra L. 2; Affiliation: 1: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: 2007, Vol. 30 Issue 1, p5; Subject Term: ISOTRETINOIN; Subject Term: TERATOGENESIS; Subject Term: TERATOGENICITY testing; Subject Term: ACNE -- Treatment; Subject Term: PREGNANCY; Subject Term: FETAL behavior; Subject Term: THERAPEUTIC use; Number of Pages: 11p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2007-14329-002
AN - 2007-14329-002
AU - Mensah, George A.
AU - Glover, Maleeka J.
ED - Williams, Richard Allen
ED - Williams, Richard Allen, (Ed)
T1 - Epidemiology of racial and ethnic disparities in health and healthcare.
T2 - Eliminating healthcare disparities in America: Beyond the IOM report.
Y1 - 2007///
SP - 21
EP - 40
CY - Totowa, NJ, US
PB - Humana Press
SN - 978-1-934115-42-8
SN - 978-1-59745-485-8
N1 - Accession Number: 2007-14329-002. Partial author list: First Author & Affiliation: Mensah, George A.; National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20080324. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-1-934115-42-8, Hardcover; 978-1-59745-485-8, PDF. Language: English. Major Descriptor: Epidemiology; Health; Health Care Delivery; Racial and Ethnic Differences. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Intended Audience: General Public (GP). References Available: Y. Page Count: 20.
AB - In this chapter, published data from national health statistics and surveillance reports is used to present epidemiological profiles of established disparities in health status and healthcare delivery for population subgroups defined by race and ethnicity. First the categories of race and ethnicity are introduced and the concept of disparities in healthcare is defined. The distribution and demographic changes in the racial and ethnic categories are presented along with current projections to the year 2050. Selected examples of the Healthy People 2010 objectives and targets for elimination of disparities are discussed. Current data and trends related to life expectancy, prevalence of risk factors and chronic diseases, other morbidity, mortality, access to care, and quality of care are then presented. The need for continued refinement of conceptual and methodological issues in the collection of healthcare data by race and ethnicity is also emphasized. The chapter concludes with caveats on the challenges and limitations in the interpretation of racial and ethnic comparisons in the healthcare setting, and describes future opportunities for the development and implementation of programs and strategies to eliminate these disparities in health and healthcare. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epidemiology
KW - racial & ethnic disparities
KW - health
KW - healthcare
KW - 2007
KW - Epidemiology
KW - Health
KW - Health Care Delivery
KW - Racial and Ethnic Differences
KW - 2007
DO - 10.1007/978-1-59745-485-8_2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-14329-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hunter, Paul R.
AU - Hadfield, Stephen J.
AU - Wilkinson, Dawn
AU - Lake, Iain R.
AU - Harrison, Florence C. D.
AU - Chalmers, Rachel M.
T1 - Subtypes of Cryptosporidium parvum in Humans and Disease Risk.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/01//
VL - 13
IS - 1
M3 - Article
SP - 82
EP - 88
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - The 2 main species of Cryptosporidium that infect humans are Cryptosporidium hominis and C. parvum. Here, multilocus fragment analysis of 3 microsatellite loci (ML1, ML2, and gp60) was used to subtype strains from sporadic cases of cryptosporidiosis in Wales and northwest England. Of 72 strains of C. parvum, 63 were typeable at all 3 loci, forming 31 subtypes. These strains formed 3 broad clusters, representing 74.6%, 20.6%, and 4.8% of typeable strains. Of 118 C. hominis strains, 106 were typeable at all 3 loci, forming 9 subtypes; however, 90% belonged to the same subtype. Analysis with epidemiologic data found an association between strains from case-patients who reported contact with farm animals and individual C. parvum microsatellite alleles. The strongest association was with ML1; all strains from case-patients that reported farm animal contact had the same allele (ML1-242). Microsatellite typing of C. parvum provides valuable additional information on the epidemiology of this pathogen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryptosporidium
KW - Diseases
KW - Cryptosporidiosis
KW - Pathogenic microorganisms
KW - Cryptosporidium parvum
KW - RISK factors
KW - Microsatellites (Genetics)
N1 - Accession Number: 23757955; Hunter, Paul R. 1; Hadfield, Stephen J. 2; Wilkinson, Dawn 1; Lake, Iain R. 1; Harrison, Florence C. D. 1; Chalmers, Rachel M. 2; Email Address: rachel.chalmers@nphs.wales.nhs.uk; Affiliations: 1: University of East Anglia, Norwich, United Kingdom; 2: National Public Health Service for Wales, Swansea, United Kingdom; Issue Info: Jan2007, Vol. 13 Issue 1, p82; Thesaurus Term: Cryptosporidium; Thesaurus Term: Diseases; Thesaurus Term: Cryptosporidiosis; Thesaurus Term: Pathogenic microorganisms; Subject Term: Cryptosporidium parvum; Subject Term: RISK factors; Subject Term: Microsatellites (Genetics); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Salamanca-Buentello, Fabio
T1 - Ethical and Scientific Issues of Nanotechnology in the Workplace.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/01//
VL - 115
IS - 1
M3 - Article
SP - 5
EP - 12
PB - Superintendent of Documents
SN - 00916765
AB - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decisionmaking about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the a) identification and communication of hazards and risks by scientists, authorities, and employers; b) workers' acceptance of risk; c) selection and implementation of controls; d) establishment of medical screening programs; and e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Health risk assessment
KW - Environmental health
KW - Industrial safety
KW - Industrial toxicology
KW - Nanoparticles
KW - Work environment
KW - Business ethics
KW - ethics
KW - hazards
KW - nanotechnology
KW - occupational safety and health
KW - particles
KW - toxicology
N1 - Accession Number: 24222524; Schulte, Paul A. 1; Email Address: pschulte@cdc.gov; Salamanca-Buentello, Fabio 2; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA; 2: University of Toronto Joint Centre for Bioethics and Canadian Program on Genomics and Global Health, Toronto, Ontario, Canada; Issue Info: Jan2007, Vol. 115 Issue 1, p5; Thesaurus Term: Hazardous substances; Thesaurus Term: Health risk assessment; Thesaurus Term: Environmental health; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial toxicology; Subject Term: Nanoparticles; Subject Term: Work environment; Subject Term: Business ethics; Author-Supplied Keyword: ethics; Author-Supplied Keyword: hazards; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: occupational safety and health; Author-Supplied Keyword: particles; Author-Supplied Keyword: toxicology; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105983501
T1 - Ethical and scientific issues of nanotechnology in the workplace.
AU - Schulte PA
AU - Salamanca-Buentello F
Y1 - 2007/01//
N1 - Accession Number: 105983501. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Nanotechnology -- Ethical Issues
KW - Occupational Exposure -- Adverse Effects
KW - Technology
KW - Occupational Health
KW - Risk Assessment
KW - Work Environment
SP - 5
EP - 12
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 115
IS - 1
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decisionmaking about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the a) identification and communication of hazards and risks by scientists, authorities, and employers; b) workers' acceptance of risk; c) selection and implementation of controls; d) establishment of medical screening programs; and e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; pschulte@cdc.gov
U2 - PMID: 17366812.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105983501&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hayward, Douglas
AU - Wong, Jon
AU - Krynitsky, Alexander J.
T1 - Polybrominated diphenyl ethers and polychlorinated biphenyls in commercially wild caught and farm-raised fish fillets in the United States
JO - Environmental Research
JF - Environmental Research
Y1 - 2007/01//
VL - 103
IS - 1
M3 - Article
SP - 46
EP - 54
SN - 00139351
AB - Abstract: Wild caught and farm-raised fish fillets collected in fish markets and large-chain super markets located in the Maryland, Washington, DC, and North Carolina were measured for their polybrominated diphenyl ether (PBDE), polychlorinated biphenyl (PCB), and polychlorodibenzo-p-dioxins/dibenzofurans (PCDD/Fs) levels. PCB and PBDE concentrations were the highest in a wild bluefish fillet (800 and 38ng/g wet weight, respectively) and the lowest in wild Coho salmon fillet (0.35 and 0.04ng/g, respectively). Levels for both PCBs and PBDEs in ng/g wet weight decreased from bluefish with medians of 200 and 6.2, to rockfish 66 and 4.7, followed by farmed-raised salmon with 9.0 and 1.1, with the lowest in wild salmon, 4.0 and 0.3ng/g for PCBs and PBDEs, respectively (PCBs are the sum of 25 congeners). The chlorinated biphenyl (CB)-153 and brominated diphenyl ether (BDE)-47 levels correlated in the 22 fish fillets with a Pearson correlation coefficient of 0.94. Bluefish, rockfish (striped bass), wild caught and farm-raised salmons all showed different linear regression slopes between CB-153 and BDE-47 of 7.5, 2.7, 0.97, and 1.5, respectively. A Wilcoxon rank sum test showed no significant difference in the CB-153/BDE-47 ratios between farmed raised and all species of wild salmon combined, but was significant between bluefish and rockfish, farmed raised salmon or wild salmon. [Copyright &y& Elsevier]
AB - Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polybrominated diphenyl ethers
KW - Polychlorinated biphenyls
KW - Fish fillets
KW - United States
KW - Bluefish
KW - Correlation
KW - Farmed fish
KW - Polybrominated diphenyl ethers (PBDES)
KW - Polychlorinated biphenyls (PCBs)
KW - Polychlorodibenzo-p-dioxins/dibenzofurans (PCDD/Fs)
KW - Salmon
KW - Striped bass
KW - Wild fish
N1 - Accession Number: 23443870; Hayward, Douglas; Email Address: douglas.hayward@fda.hhs.gov; Wong, Jon 1; Krynitsky, Alexander J. 1; Affiliations: 1: US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Jan2007, Vol. 103 Issue 1, p46; Thesaurus Term: Polybrominated diphenyl ethers; Thesaurus Term: Polychlorinated biphenyls; Subject Term: Fish fillets; Subject: United States; Author-Supplied Keyword: Bluefish; Author-Supplied Keyword: Correlation; Author-Supplied Keyword: Farmed fish; Author-Supplied Keyword: Polybrominated diphenyl ethers (PBDES); Author-Supplied Keyword: Polychlorinated biphenyls (PCBs); Author-Supplied Keyword: Polychlorodibenzo-p-dioxins/dibenzofurans (PCDD/Fs); Author-Supplied Keyword: Salmon; Author-Supplied Keyword: Striped bass; Author-Supplied Keyword: Wild fish; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.envres.2006.05.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23443870&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bough, Kristopher J.
AU - Rho, Jong M.
T1 - Anticonvulsant Mechanisms of the Ketogenic Diet.
JO - Epilepsia (Series 4)
JF - Epilepsia (Series 4)
Y1 - 2007/01//
VL - 48
IS - 1
M3 - Article
SP - 43
EP - 58
PB - Wiley-Blackwell
SN - 00139580
AB - The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy. Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain unknown. In this review, we present one intersecting view of how the KD may exert its anticonvulsant activity against the backdrop of several seemingly disparate mechanistic theories. We summarize key insights gleaned from experimental and clinical studies of the KD, and focus particular attention on the role that ketone bodies, fatty acids, and limited glucose may play in seizure control. Chronic ketosis is anticipated to modify the tricarboxcylic acid cycle to increase GABA synthesis in brain, limit reactive oxygen species (ROS) generation, and boost energy production in brain tissue. Among several direct neuro-inhibitory actions, polyunsaturated fatty acids increased after KD induce the expression of neuronal uncoupling proteins (UCPs), a collective up-regulation of numerous energy metabolism genes, and mitochondrial biogenesis. These effects further limit ROS generation and increase energy production. As a result of limited glucose and enhanced oxidative phosphorylation, reduced glycolytic flux is hypothesized to activate metabolic KATP channels and hyperpolarize neurons and/or glia. Although it is unlikely that a single mechanism, however well substantiated, will explain all of the diet's clinical benefits, these diverse, coordinated changes seem poised to stabilize synaptic function and increase the resistance to seizures throughout the brain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KETOGENIC diet
KW - EPILEPSY -- Treatment
KW - ACETONEMIA
KW - DIET in disease
KW - KETONES
KW - METABOLISM
KW - Epilepsy
KW - Ketogenic diet
KW - Metabolism
KW - Polyunsaturated fatty acids
N1 - Accession Number: 23658981; Bough, Kristopher J. 1; Email Address: Kristopher.Bough@fda.hhs.gov Rho, Jong M. 2; Affiliation: 1: Center for Drug Evaluation & Research, Food and Drug Administration, Rockville, Maryland 2: Barrow Neurological Institute, Phoenix, Arizona, U.S.A.; Source Info: Jan2007, Vol. 48 Issue 1, p43; Subject Term: KETOGENIC diet; Subject Term: EPILEPSY -- Treatment; Subject Term: ACETONEMIA; Subject Term: DIET in disease; Subject Term: KETONES; Subject Term: METABOLISM; Author-Supplied Keyword: Epilepsy; Author-Supplied Keyword: Ketogenic diet; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Polyunsaturated fatty acids; Number of Pages: 16p; Illustrations: 4 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1111/j.1528-1167.2007.00915.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23658981&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dickensheets, H.
AU - Vazquez, N.
AU - Sheikh, F.
AU - Gingras, S.
AU - Murray, P. J.
AU - Ryan, J. J.
AU - Donnelly, R. P.
T1 - Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling.
JO - Genes & Immunity
JF - Genes & Immunity
Y1 - 2007/01//
VL - 8
IS - 1
M3 - Article
SP - 21
EP - 27
PB - Nature Publishing Group
SN - 14664879
AB - Interferon-γ and interleukin-4 (IL-4) induce distinct gene expression profiles in macrophages by differentially activating signal transducers and activators of transcription (STAT)1 and STAT6, respectively. The role of suppressor of cytokine signaling (SOCS)-1 as a negative regulator of IFN-γ signaling is well established. However, its potential role as a negative regulator of IL-4 signaling has not been explored. We found that IL-4, like IFN-γ, induces rapid de novo expression of SOCS-1 in primary macrophages. Induction of SOCS-1 gene expression by IL-4 is STAT6-dependent, whereas induction of SOCS-1 by IFN-γ is STAT1-dependent. Unlike their common ability to induce expression of SOCS-1, IL-4 also induced expression of SOCS-2 but not SOCS-3 in macrophages, whereas IFN-γ induced expression of SOCS-3 but not SOCS-2. Forced expression of SOCS-1 or SOCS-3, but not SOCS-2, inhibited activation of STAT6 by IL-4. Moreover, SOCS-1 appears to serve as an endogenous regulator of IL-4 signaling in macrophages because the magnitude and duration of STAT6 activation as well as IL-4-mediated gene expression were much greater in SOCS-1-deficient (SOCS-1−/−) macrophages than in wild-type macrophages. Our findings demonstrate that, like IFN-γ, IL-4 also induces expression of SOCS-1 in macrophages, and SOCS-1 feedback inhibits expression of STAT6-responsive genes.Genes and Immunity (2007) 8, 21–27. doi:10.1038/sj.gene.6364352; published online 9 November 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Genes & Immunity is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - GENE expression
KW - INTERLEUKIN-4
KW - MACROPHAGES
KW - INTERFERONS
KW - SUPPRESSOR cells
KW - GENETIC transcription
KW - interleukin-4
KW - macrophages
KW - SOCS
KW - STAT6
N1 - Accession Number: 23773798; Dickensheets, H. 1 Vazquez, N. 1 Sheikh, F. 1 Gingras, S. 2 Murray, P. J. 3 Ryan, J. J. 4 Donnelly, R. P. 1; Email Address: Raymond.Donnelly@fda.hhs.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN, USA 3: Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA 4: Department of Biology, Virginia Commonwealth University, Richmond, VA, USA; Source Info: Jan2007, Vol. 8 Issue 1, p21; Subject Term: CYTOKINES; Subject Term: GENE expression; Subject Term: INTERLEUKIN-4; Subject Term: MACROPHAGES; Subject Term: INTERFERONS; Subject Term: SUPPRESSOR cells; Subject Term: GENETIC transcription; Author-Supplied Keyword: interleukin-4; Author-Supplied Keyword: macrophages; Author-Supplied Keyword: SOCS; Author-Supplied Keyword: STAT6; Number of Pages: 7p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1038/sj.gene.6364352
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23773798&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2006-11867-006
AN - 2006-11867-006
AU - Nguyen, Ly
AU - Huang, Larke Nahme
ED - Leong, Frederick T. L.
ED - Ebreo, Angela
ED - Kinoshita, Lisa
ED - Inman, Arpana G.
ED - Yang, Lawrence Hsin
ED - Fu, Michi
ED - Leong, Frederick T. L., (Ed)
ED - Ebreo, Angela, (Ed)
ED - Kinoshita, Lisa, (Ed)
ED - Inman, Arpana G., (Ed)
ED - Yang, Lawrence Hsin, (Ed)
ED - Fu, Michi, (Ed)
T1 - Understanding Asian American Youth Development: A Social Ecological Perspective.
T2 - Handbook of Asian American psychology, 2nd ed.
Y1 - 2007///
SP - 87
EP - 103
CY - Thousand Oaks, CA, US
PB - Sage Publications, Inc
SN - 1-4129-2467-7
SN - 9781412-924672
SN - 1-4129-4133-4
SN - 9781412924672
N1 - Accession Number: 2006-11867-006. Partial author list: First Author & Affiliation: Nguyen, Ly; Office of the Administrator at the Substance Abuse and Mental Health Services Administration, U.S. Dept of Health and Human Services, US. Release Date: 20070212. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-4129-2467-7, Paperback; 9781412-924672, Paperback; 1-4129-4133-4, Hardcover; 9781412924672, Hardcover. Language: English. Major Descriptor: Asians; Childhood Development; Minority Groups. Classification: Developmental Psychology (2800). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 17.
AB - The purpose of this chapter is to examine the current research on Asian American child development using an organizational framework that best captures the experience of a minority group in America. Whereas most theories of child and youth development focus on the individual person, understanding the developmental process for a child of color in the United States needs to be embedded in critical contextual issues. The integrative model of child development proposed by Garcia Coll and colleagues (1996) is a social ecological perspective that provides face validity for understanding Asian American child development. Garcia Coll's model represents a significant advancement in child development theory, and as such, it is used here to frame the discussion of existing research on Asian American children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Asian American
KW - youth development
KW - social ecological perspective
KW - minority groups
KW - 2007
KW - Asians
KW - Childhood Development
KW - Minority Groups
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-11867-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-12897-001
AN - 2006-12897-001
AU - Carayon, Pascale
AU - Henriksen, Kerm
ED - Carayon, Pascale
ED - Carayon, Pascale, (Ed)
T1 - I: Introduction.
T2 - Handbook of human factors and ergonomics in health care and patient safety.
Y1 - 2007///
SP - 3
EP - 37
CY - Mahwah, NJ, US
PB - Lawrence Erlbaum Associates Publishers
SN - 0-8058-4885-1
SN - 9780805848854
N1 - Accession Number: 2006-12897-001. Partial author list: First Author & Affiliation: Carayon, Pascale; University of Wisconsin, Madison, WI, US. Release Date: 20070402. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-8058-4885-1, Hardcover; 9780805848854, Hardcover. Language: English. Major Descriptor: Health Care Services; Human Factors Engineering; Patients; Safety. Classification: Human Factors Engineering (4010); Inpatient & Hospital Services (3379). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 35.
AB - 'Human Factors and Egonomics in Healh Care and Patient Safety' / Pascale Carayon / This handbook of human factors and ergonomics (HFE) in health care and patient safety addresses the challenge described by Leape by presenting and discussing a variety of HFE issues, concepts, and methods that can help understand, identify, mitigate, and remove the obstacles to safe health care. 'Human Factors and Patient Safety: Continuing Challenges' / Kerm Henriksen / This chapter focuses on a few fundamental issues that continue to thwart the full potential of human factors and ergonomic practices for enhancing patient safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human factors
KW - ergonomics
KW - health care
KW - patient safety
KW - 2007
KW - Health Care Services
KW - Human Factors Engineering
KW - Patients
KW - Safety
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12897-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-12897-003
AN - 2006-12897-003
AU - Murphy, Lawrence R.
AU - Williams, Eric S.
AU - McMurray, Julia
AU - Baier-Manwell, Linda
AU - Schwartz, Mark D.
AU - Linzer, Mark
AU - Itoh, Kenji
AU - Andersen, Henning Boje
AU - Madsen, Marlene Dryølv
AU - Schaufeli, Wilmar B.
AU - Harvey, Craig M.
AU - Schuster, Richard J.
AU - Durso, Francis T.
AU - Matthews, Amy L.
AU - Surabattula, Deepti
AU - Roberts, Karlene H.
AU - Desai, Vinit
AU - Madsen, Peter
AU - Baker, David P.
AU - Salas, Eduardo
AU - Barach, Paul
AU - Battles, James
AU - King, Heidi
ED - Carayon, Pascale
ED - Carayon, Pascale, (Ed)
T1 - III: Job and Organizational Design.
T2 - Handbook of human factors and ergonomics in health care and patient safety.
Y1 - 2007///
SP - 161
EP - 271
CY - Mahwah, NJ, US
PB - Lawrence Erlbaum Associates Publishers
SN - 0-8058-4885-1
SN - 9780805848854
N1 - Accession Number: 2006-12897-003. Partial author list: First Author & Affiliation: Murphy, Lawrence R.; National Institute for Occupational Safety and Health (NIOSH), US. Release Date: 20070402. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-8058-4885-1, Hardcover; 9780805848854, Hardcover. Language: English. Major Descriptor: Human Factors Engineering; Occupational Stress; Safety; Treatment Outcomes; Health Personnel. Minor Descriptor: Patients; Work Teams. Classification: Human Factors Engineering (4010); Inpatient & Hospital Services (3379). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 111.
AB - 'Job Stress in Health Care Workers' / Lawrence R. Murphy 'Effect of Workplace Stress on Patient Outcomes' / Eric S. Williams, Julia McMurray, Linda Baier-Manwell, Mark D. Schwartz, and Mark Linzer 'Safety Culture in Health Care' / Kenji Itoh, Henning Boje Andersen, and Marlene Dryølv Madsen 'Burnout in Health Care' / Wilmar B. Schaufeli 'Human Factors of Transition of Care' / Craig M. Harvey, Richard J. Schuster, Francis T. Durso, Amy L. Matthews, and Deepti Surabattula 'Reliability Enhancement and Demise at Bay Medical Center's Children's Hospital' / Karlene H. Roberts, Vinit Desai, and Peter Madsen 'The Relation Between Teamwork and Patient Safety' / David P. Baker, Eduardo Salas, Paul Barach, James Battles, and Heidi King. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job & workplace stress
KW - health care workers
KW - patient outcomes
KW - human factors
KW - ergonomics
KW - teamwork
KW - patient safety
KW - 2007
KW - Human Factors Engineering
KW - Occupational Stress
KW - Safety
KW - Treatment Outcomes
KW - Health Personnel
KW - Patients
KW - Work Teams
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-12897-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-20618-026
AN - 2006-20618-026
AU - Berger, Lawrence R.
AU - Grossman, David C.
ED - Doll, Lynda S.
ED - Bonzo, Sandra E.
ED - Mercy, James A.
ED - Sleet, David A.
ED - Doll, Lynda S., (Ed)
ED - Bonzo, Sandra E., (Ed)
ED - Mercy, James A., (Ed)
ED - Sleet, David A., (Ed)
T1 - Evaluating fidelity and effectiveness of interventions.
T2 - Handbook of injury and violence prevention.
Y1 - 2007///
SP - 463
EP - 477
CY - New York, NY, US
PB - Springer Science + Business Media
SN - 0-387-25924-4
SN - 978-0-387-25924-6
SN - 0-387-29457-0
SN - 978-0-387-29457-5
AD - Berger, Lawrence R., Indian Health Service Injury Prevention Program, Albuquerque, NM, US, 87106
N1 - Accession Number: 2006-20618-026. Partial author list: First Author & Affiliation: Berger, Lawrence R.; Indian Health Service Injury Prevention Program, Albuquerque, NM, US. Release Date: 20070813. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-387-25924-4, Hardcover; 978-0-387-25924-6, Hardcover; 0-387-29457-0, PDF; 978-0-387-29457-5, PDF. Language: English. Major Descriptor: Injuries; Intervention; Prevention; Program Evaluation; Public Health. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 15.
AB - The purpose of this chapter is to review approaches toward the evaluation of program effectiveness and fidelity. The intended audience for this chapter is primarily injury control and public health program administrators and their staff. In this chapter, we describe two specific scenarios frequently faced by program administrators. The first is the development of an evaluation section of a funding proposal from a state government department of health to disseminate an injury prevention intervention. The second involves planning for a site visit to evaluate an injury prevention program in a state or local health department. Both require extensive preparation and coordination of people and activities. Both require careful attention to program implementation and evaluation strategies. We believe that the execution of these scenarios illustrates some of the practical principles regarding the evaluation of program fidelity and effectiveness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - injury prevention
KW - public health
KW - intervention
KW - program effectiveness & fidelity
KW - evaluation
KW - 2007
KW - Injuries
KW - Intervention
KW - Prevention
KW - Program Evaluation
KW - Public Health
KW - 2007
DO - 10.1007/978-0-387-29457-5_26
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20618-026&site=ehost-live&scope=site
UR - navajo@u.washington.edu
UR - bergerlaw@msn.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Zuvekas, Samuel H.
AU - Cohen, Joel W.
T1 - Prescription Drugs And The Changing Concentration Of Health Care Expenditures.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/01//Jan/Feb2007
VL - 26
IS - 1
M3 - Article
SP - 249
EP - 257
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Health care expenditures are highly concentrated in the United States, with a small fraction of the population accounting for a large share of total health spending. This concentration has proved remarkably stable over time; however, the degree of concentration has declined over the past decade. Using data from the 1996-2003 Medical Expenditure Panel Survey (MEPS), we explore why. We find that rapid growth in prescription drug spending, which is diffused over a large fraction of the population, versus slower growth in spending for inpatient care largely accounts for the recent change in concentration. We discuss the potential implications for current cost containment and reform efforts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - HEALTH surveys
KW - DRUGS
KW - HOSPITAL care
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 23850174; Zuvekas, Samuel H. 1; Email Address: szuvekas@ahrq.gov Cohen, Joel W. 2; Affiliation: 1: Senior Economist, Division of Social and Economic Research Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), Rockville Maryland 2: Director, Division of Social and Economic Research Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), Rockville Maryland; Source Info: Jan/Feb2007, Vol. 26 Issue 1, p249; Subject Term: MEDICAL care costs; Subject Term: HEALTH surveys; Subject Term: DRUGS; Subject Term: HOSPITAL care; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
L3 - 10.1377/hlthaff.26.1.249
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23850174&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Chunliu Zhan
T1 - Adverse Events: The Authors Respond.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/01//Jan/Feb2007
VL - 26
IS - 1
M3 - Letter
SP - 293
EP - 294
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - A response by Chunliu Zhan to a letter to the editor about his article "Do Hospitals Make or Lose Money on Adverse Events?," in the September to October 2006 issue is presented.
KW - LETTERS to the editor
KW - HOSPITALS -- Finance
N1 - Accession Number: 23850183; Chunliu Zhan 1; Affiliation: 1: Agency for Healthcare Research and Quality Rockville, Maryland; Source Info: Jan/Feb2007, Vol. 26 Issue 1, p293; Subject Term: LETTERS to the editor; Subject Term: HOSPITALS -- Finance; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 2p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23850183&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106281982
T1 - Prescription drugs and the changing concentration of health care expenditures.
AU - Zuvekas SH
AU - Cohen JW
Y1 - 2007/01//Jan/Feb2007
N1 - Accession Number: 106281982. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Drugs, Prescription -- Economics
KW - Health Care Costs -- Economics
KW - Health Care Reform
KW - Ambulatory Care -- Economics
KW - Cost Control
KW - Health Policy -- Economics
KW - Hospitalization -- Economics
KW - Secondary Analysis
KW - Human
SP - 249
EP - 257
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 26
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Health care expenditures are highly concentrated in the United States, with a small fraction of the population accounting for a large share of total health spending. This concentration has proved remarkably stable over time; however, the degree of concentration has declined over the past decade. Using data from the 1996-2003 Medical Expenditure Panel Survey (MEPS), we explore why. We find that rapid growth in prescription drug spending, which is diffused over a large fraction of the population, versus slower growth in spending for inpatient care largely accounts for the recent change in concentration. We discuss the potential implications for current cost containment and reform efforts.
SN - 0278-2715
AD - Senior Economist, Division of Social and Economic Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 17211035.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106281982&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Emergency Departments in Crisis: Opportunities for Research.
JO - Health Services Research
JF - Health Services Research
Y1 - 2007/01//
VL - 42
IS - 1P1
M3 - Article
SP - 13
EP - 20
PB - Wiley-Blackwell
SN - 00179124
AB - The article focuses on emergency medical services in United States. According to Institute of Medicine (IOM), U. S. emergency care is highly fragmented, overburdened and underfunded. IOM have an action agenda for the improvement of emergency care including the development fof an accountable system, creation of a lead federal agency, increase in emergency funding and others. AHRQ has conducted research for assuring and enhancing the quality and safety of U. S. emergency services.
KW - EMERGENCY medical services
KW - EMERGENCY medicine
KW - MEDICAL care
KW - RESCUE work
KW - HOSPITAL emergency services
KW - PRIORITY (Philosophy)
KW - RESEARCH -- Evaluation
KW - UNITED States
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 23729199; Clancy, Carolyn M. 1; Affiliation: 1: Agency for Healthcare Research and Quality, John M. Eisenberg Building, 540 Gaither Road, Rockville, MD 20850; Source Info: Jan2007, Vol. 42 Issue 1P1, p13; Subject Term: EMERGENCY medical services; Subject Term: EMERGENCY medicine; Subject Term: MEDICAL care; Subject Term: RESCUE work; Subject Term: HOSPITAL emergency services; Subject Term: PRIORITY (Philosophy); Subject Term: RESEARCH -- Evaluation; Subject Term: UNITED States; Company/Entity: UNITED States. Agency for Healthcare Research & Quality; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 913130 Municipal police services; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1475-6773.2006.00692.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23729199&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Johnson, Barry L.
T1 - Tough Year 2006 for the USEPA and the CDC: Leadership Lapses?
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2007/01//Jan/Feb2007
VL - 13
IS - 1
M3 - Editorial
SP - 3
EP - 6
SN - 10807039
AB - The author reflects on challenges the U. S. Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention (CDC) have faced during 2006. The author reviews the issues of particulate matter air pollution standards and the dioxin risk re-assessment. He discusses the EPA authority to regulate greenhouse gases. He considers staffing changes at the CDC as a result of reorganization in 2003 which created coordinating centers.
KW - AIR pollution standards
KW - GREENHOUSE gases
KW - ENVIRONMENTAL policy
KW - CENTERS for Disease Control & Prevention (U.S.) -- Officials & employees
KW - UNITED States
KW - UNITED States. Environmental Protection Agency
N1 - Accession Number: 23828628; Johnson, Barry L. 1; Affiliation: 1: Assistant Surgeon General (ret.), U.S. Public Health Service. Editor-in-Chief; Source Info: Jan/Feb2007, Vol. 13 Issue 1, p3; Subject Term: AIR pollution standards; Subject Term: GREENHOUSE gases; Subject Term: ENVIRONMENTAL policy; Subject Term: CENTERS for Disease Control & Prevention (U.S.) -- Officials & employees; Subject Term: UNITED States; Company/Entity: UNITED States. Environmental Protection Agency; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1080/10807030601179758
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23828628&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nishikido, Noriko
AU - Matsuda, Kazumi
AU - Fukuda, Eiko
AU - Motoki, Chiharu
AU - Tsutaki, Miho
AU - Kawakami, Yuko
AU - Yuasa, Akiko
AU - Iijima, Miyoko
AU - Tanaka, Mika
AU - Hirata, Mamoru
AU - Hojoh, Minoru
AU - Ikeda, Tomoko
AU - Maeda, Kazutoshi
AU - Miyoshi, Yukari
AU - Arai, Sumiko
AU - Mitsuhashi, Hiroyuki
T1 - Development and Process Evaluation of the Participatory and Action-Oriented Empowerment Model Facilitated by Occupational Health Nurses for Workplace Health Promotion in Small and Medium-Sized Enterprises.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/01//
VL - 45
IS - 1
M3 - Article
SP - 62
EP - 73
SN - 00198366
AB - The article offers information regarding a study that aims to develop an available empowerment model for workplace health promotion (WHP) in small and medium-sized enterprises (SME), as well as to evaluate its applicability and feasibility. Semi-structured interviews were conducted to employers and workers in SME. Moreover, the new empowerment was tackled by several rounds on focus group meetings, with occupational safety and health researchers and practitioners based on the interviews.
KW - Industrial hygiene
KW - Employee health promotion
KW - Health promotion
KW - Small business
KW - Feasibility studies
KW - Information-focused tools
KW - Occupational health nurses
KW - Participatory and actionoriented empowerment model
KW - Small and medium-sized enterprises
KW - Workplace health promotion
N1 - Accession Number: 25382609; Nishikido, Noriko 1; Matsuda, Kazumi 2; Fukuda, Eiko 1; Motoki, Chiharu 1; Tsutaki, Miho 1; Kawakami, Yuko 1; Yuasa, Akiko 1; Iijima, Miyoko 3; Tanaka, Mika 4; Hirata, Mamoru 5; Hojoh, Minoru 6; Ikeda, Tomoko 7; Maeda, Kazutoshi 8; Miyoshi, Yukari 9; Arai, Sumiko 10; Mitsuhashi, Hiroyuki 11; Affiliations: 1: Department of Community Health Nursing, School of Health Sciences, Tokai University, Bohseidai, Iseharashi, Kanagawa, Japan; 2: The Social Insurance Health Project Foundation, Tokyo, Japan; 3: Office Iijima, Kanagawa, Japan; 4: Kyushu University of Nursing and Social Welfare, Kumamoto, Japan; 5: National Institute of Occupational Safety and Health, Kanagawa, Japan; 6: Ota Regional Occupational Health Center, Tokyo, Japan; 7: Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan; 8: Job Stress Care Japan; 9: All-Japan Federation of National Health Insurance Organization, Japan; 10: Tokyo Metropolitan Government, Tokyo, Japan; 11: Japan Family Planning Association, Inc., Japan; Issue Info: 2007, Vol. 45 Issue 1, p62; Thesaurus Term: Industrial hygiene; Subject Term: Employee health promotion; Subject Term: Health promotion; Subject Term: Small business; Subject Term: Feasibility studies; Author-Supplied Keyword: Information-focused tools; Author-Supplied Keyword: Occupational health nurses; Author-Supplied Keyword: Participatory and actionoriented empowerment model; Author-Supplied Keyword: Small and medium-sized enterprises; Author-Supplied Keyword: Workplace health promotion; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xu, Lixin
AU - Frucht, David M.
T1 - Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses
JO - International Journal of Biochemistry & Cell Biology
JF - International Journal of Biochemistry & Cell Biology
Y1 - 2007/01//
VL - 39
IS - 1
M3 - Article
SP - 20
EP - 24
SN - 13572725
AB - Abstract: Lethal factor (LF), along with its receptor-binding partner protective antigen (PA), forms lethal toxin (LT), a critical virulence factor for Bacillus anthracis. LF is a Zn2+ protease that cleaves specific mitogen activated protein kinase kinases (MAPKKs), inactivating signal transduction intermediates required for normal immune function. Initial research emphasized the role of LT in attenuating pro-inflammatory responses by macrophages, the primary targets of infection. More recent studies have revealed that LT affects a broad range of immune cells. In addition to direct effects on macrophages and neutrophils, LT suppresses the costimulatory functions of dendritic cells, thereby impeding essential cross-talk between innate and adaptive immune responses. Moreover, LT acts directly on T and B lymphocytes, blocking antigen receptor-dependent proliferation, cytokine production and Ig production. In this manner, LT mounts a broad-based attack on host immunity, thus providing B. anthracis with multiple mechanisms for avoiding protective host responses. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Biochemistry & Cell Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS anthracis
KW - PROTEIN kinases
KW - BACTERIAL diseases
KW - MICROBIAL genetics
KW - Bacillus anthracis
KW - edema factor ( EF )
KW - edema toxin ( ET )
KW - lethal factor ( LF )
KW - Lethal toxin
KW - lethal toxin ( LT )
KW - mitogen activated protein kinase kinase ( MAPKK )
KW - Pathogenesis
KW - protective antigen ( PA )
N1 - Accession Number: 22723866; Xu, Lixin 1 Frucht, David M.; Email Address: david.frucht@fda.hhs.gov; Affiliation: 1: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, United States Food and Drug Administration, Building 29B, Room 3NN22, Bethesda, MD 20892, USA; Source Info: Jan2007, Vol. 39 Issue 1, p20; Subject Term: BACILLUS anthracis; Subject Term: PROTEIN kinases; Subject Term: BACTERIAL diseases; Subject Term: MICROBIAL genetics; Author-Supplied Keyword: Bacillus anthracis; Author-Supplied Keyword: edema factor ( EF ); Author-Supplied Keyword: edema toxin ( ET ); Author-Supplied Keyword: lethal factor ( LF ); Author-Supplied Keyword: Lethal toxin; Author-Supplied Keyword: lethal toxin ( LT ); Author-Supplied Keyword: mitogen activated protein kinase kinase ( MAPKK ); Author-Supplied Keyword: Pathogenesis; Author-Supplied Keyword: protective antigen ( PA ); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.biocel.2006.08.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shames, D.
AU - Monroe, S. E.
AU - Davis, D.
AU - Soule, L.
T1 - Regulatory perspective on clinical trials and end points for female sexual dysfunction, in particular, hypoactive sexual desire disorder: formulating recommendations in an environment of evolving clinical science.
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
Y1 - 2007/01//Jan/Feb2007
VL - 19
IS - 1
M3 - Article
SP - 30
EP - 36
PB - Nature Publishing Group
SN - 09559930
AB - This article examines the history, current status, and potential future challenges in the development of drugs for female sexual dysfunction (FSD) from the perspective of the United States Food and Drug Administration. In particular, the article focuses on testosterone therapy for hypoactive sexual desire disorder (a component of FSD), and the role of the Division of Reproductive and Urologic Products in facilitating the development of safe and effective therapies for this indication.International Journal of Impotence Research (2007) 19, 30–36. doi:10.1038/sj.ijir.3901481; published online 25 May 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Impotence Research is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - SEXUAL dysfunction
KW - SEXUAL desire disorders
KW - CLINICAL medicine
KW - MEDICAL research
KW - UNITED States
KW - female sexual dysfunction (FSD)
KW - hypoactive sexual desire disorder (HSDD)
KW - testosterone therapy in women
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 23580378; Shames, D. 1; Email Address: daniel.shames@fda.hhs.gov Monroe, S. E. 1 Davis, D. 1 Soule, L. 1; Affiliation: 1: Division of Reproductive and Urologic Products, Food and Drug Administration, Silver Spring, MD, USA; Source Info: Jan/Feb2007, Vol. 19 Issue 1, p30; Subject Term: DRUG development; Subject Term: SEXUAL dysfunction; Subject Term: SEXUAL desire disorders; Subject Term: CLINICAL medicine; Subject Term: MEDICAL research; Subject Term: UNITED States; Author-Supplied Keyword: female sexual dysfunction (FSD); Author-Supplied Keyword: hypoactive sexual desire disorder (HSDD); Author-Supplied Keyword: testosterone therapy in women; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/sj.ijir.3901481
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hwang, Dae Y.
AU - Chae, Kab R.
AU - Kim, Chuel K.
AU - Kim, Byoung G.
AU - Shim, Sun B.
AU - Jee, Seung W.
AU - Lee, Su H.
AU - Sin, Ji S.
AU - Jang, Mee K.
AU - Seo, Su J.
AU - Kim, Min S.
AU - Cho, Jung S.
AU - Sheen, Yhun Y.
AU - Choi, Soo Y.
AU - Kim, Yong K.
T1 - Differential Effect of 7,12-Dimethylbenz[a]anthracene on Human and Mouse CYP1B1 from Livers of Castrated Transgenic Mice.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2007/01//Jan/Feb2007
VL - 26
IS - 1
M3 - Article
SP - 71
EP - 80
PB - Taylor & Francis Ltd
SN - 10915818
AB - Humanized transgenic mice coexpressing tetracycline-controlled transactivator (tTA) and human cytochrome P450 1B1 (CYP1B1) (hCYP1B1) have been created by this group. The aims of this study was to determine if 7,12-dimethylbenz[a]anthracene (DMBA) functions as testosterone or doxycycline in its ability to induce or reduce expression of hCYP1B1 or endogenous mouse CYP1B1 (mCYP1B1). This was tested in the livers by treating castrated transgenic males and hCYP1B1/luciferase-transfected cells with DMBA. Herein, DMBA-treated group exhibited (i) gradual reduction of hCYP1B1 expression at the transcript, protein, and activity levels but gradually induced its transcript level during DMBA release; (ii) gradual reduction of hCYP1B1 at the transcript and protein levels, as in the case of doxycycline or testosterone; (iii) gradual induction of mCYP1B1 expression at the transcript and protein levels but gradually reduced its transcript level during DMBA release. In parallel, DMBA-treated transfected cells exhibited gradual increase in luciferase activity in a time-and dose-dependent manner. Thus, castrated transgenic males or in vitro system could be useful as models for the detection of polycyclic aromatic hydrocarbons (PAHs) or environmental toxicants by measuring either hCYP1B1 or mCYP1B1 expressions. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Hydrocarbons
KW - Transgenic animals
KW - Polycyclic aromatic compounds
KW - Mice as laboratory animals
KW - Cytochromes
KW - Androgens
KW - Testosterone
KW - Transgenic mice
KW - Cells
KW - CYP1B1
KW - DMBA
KW - Doxycycline
KW - Transgenic Mice
N1 - Accession Number: 24232862; Hwang, Dae Y. 1; Chae, Kab R. 1; Kim, Chuel K. 1; Kim, Byoung G. 1; Shim, Sun B. 1; Jee, Seung W. 1; Lee, Su H. 1; Sin, Ji S. 1; Jang, Mee K. 1; Seo, Su J. 1; Kim, Min S. 1; Cho, Jung S. 1; Sheen, Yhun Y. 2; Choi, Soo Y. 3; Kim, Yong K. 1; Email Address: kimyongkyu@hanmail.net; Affiliations: 1: Laboratory Animal Resources Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; 2: College of Pharmacy, Ewha Womans University, Seoul, Korea; 3: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Issue Info: Jan/Feb2007, Vol. 26 Issue 1, p71; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Hydrocarbons; Thesaurus Term: Transgenic animals; Thesaurus Term: Polycyclic aromatic compounds; Subject Term: Mice as laboratory animals; Subject Term: Cytochromes; Subject Term: Androgens; Subject Term: Testosterone; Subject Term: Transgenic mice; Subject Term: Cells; Author-Supplied Keyword: CYP1B1; Author-Supplied Keyword: DMBA; Author-Supplied Keyword: Doxycycline; Author-Supplied Keyword: Transgenic Mice; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article
L3 - 10.1080/10915810601120640
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106262350
T1 - Pandemic influenza: a brief history and primer.
AU - Brasseur JW
Y1 - 2007/01//
N1 - Accession Number: 106262350. Language: English. Entry Date: 20070406. Revision Date: 20150818. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9513102.
KW - Disease Outbreaks
KW - Influenza, Avian
KW - Disease Outbreaks -- Prevention and Control
KW - Influenza Vaccine -- Administration and Dosage
KW - Influenza -- Classification
KW - Influenza -- History
KW - Influenza -- Prevention and Control
KW - Viruses -- Classification
SP - 24
EP - 28
JO - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JF - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JA - JAAPA J AM ACAD PHYSICIAN ASSIST
VL - 20
IS - 1
CY - New York, New York
PB - Haymarket Media, Inc.
AB - The avian flu, a virulent strain of type A influenza, threatens to cause the next pandemic. Although antivirals are effective, the most appropriate dosage has yet to be determined -- and creating a large enough supply could be another stumbling block.
SN - 1547-1896
AD - Health Resources and Services Administration Regional Bioterrorism Coordinator, Saginaw, MI
U2 - PMID: 17252675.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dewan S. Billal
AU - Daniel P. Fedorko
AU - S. Steve Yan
AU - Muneki Hotomi
AU - Keiji Fujihara
AU - Nancy Nelson
AU - Noboru Yamanaka
T1 - In vitro induction and selection of fluoroquinolone-resistant mutants of Streptococcus pyogenes strains with multiple emm types.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2007/01//
VL - 59
IS - 1
M3 - Article
SP - 28
EP - 34
SN - 03057453
AB - Objectives: To perform a systematic analysis of point mutations in the quinolone resistance determining regions (QRDRs) of the DNA gyrase and topoisomerase genes of emm type 6 and other emm types of Streptococcus pyogenes strains after in vitro exposure to stepwise increasing concentrations of levofloxacin.Methods: Twelve parent strains of S. pyogenes, each with a different emm type, were chosen for stepwise exposure to increasing levels of levofloxacin followed by selection of resistant mutants. The QRDRs of gyrA, gyrB, parC and parE correlating to mutants with increased MICs were analysed for point mutations.Results: Multiple mutants with significantly increased MICs were generated from each strain. The amino acid substitutions identified were consistent regardless of emm type and were similar to the mechanisms of resistance reported in clinical isolates of S. pyogenes. The number of induction/selection cycles required for the emergence of key point mutations in gyrA and parC was variable among strains. For each parent-mutant set, when MIC increased, serine-81 of gyrA and serine-79 of parC were the primary targets for amino acid substitutions. No point mutations were found in the QRDRs of gyrB and parE in any of the resistant mutants sequenced.Conclusions: Despite its intrinsic polymorphism in the QRDR of parC, emm type 6 is not more likely to develop high-level resistance to fluoroquinolones when compared with other emm types. All emm types seem equally inducible to high-level fluoroquinolone resistance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Quinolone antibacterial agents
KW - Systematic reviews (Medical research)
KW - Streptococcus pyogenes
KW - Genetic polymorphisms
N1 - Accession Number: 23642708; Dewan S. Billal 1; Daniel P. Fedorko 2; S. Steve Yan 3; Muneki Hotomi 1; Keiji Fujihara 1; Nancy Nelson 2; Noboru Yamanaka 1; Affiliations: 1: Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University 811-1 Kimiidera, Wakayama, 641-8510, Japan; 2: Clinical Center, National Institutes of Health, Department of Health and Human Services Bethesda, MD 20892, USA; 3: Food and Drug Administration, Department of Health and Human Services Rockville, MD 20855, USA; Issue Info: Jan2007, Vol. 59 Issue 1, p28; Thesaurus Term: Quinolone antibacterial agents; Subject Term: Systematic reviews (Medical research); Subject Term: Streptococcus pyogenes; Subject Term: Genetic polymorphisms; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Poli, Mark A.
AU - Rivera, Victor R.
AU - Neal, Dwayne D.
AU - Baden, Daniel G.
AU - Messer, Shawn A.
AU - Plakas, Steven M.
AU - Dickey, Robert W.
AU - El Said, Kathleen
AU - Flewelling, Leanne
AU - Green, David
AU - White, Jill
T1 - An Electrochemiluminescence-Based Competitive Displacement Immunoassay for the Type-2 Brevetoxins in Oyster Extracts.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/01//Jan/Feb2007
VL - 90
IS - 1
M3 - Article
SP - 173
EP - 178
PB - AOAC International
SN - 10603271
AB - The article focuses on the development of a competitive electrochemiluminescence-based immunoassay for the type-2 brevetoxins in oyster extracts. Among the key advantages offered by the immunoassay are speed, simplicity and low limit of quantitation. The authors believe that the immunoassay could support pharmacokinetic studies in animals and clinical evaluation of neurotoxic shellfish poisoning victims.
KW - CHEMILUMINESCENCE immunoassay
KW - ANIMAL extracts
KW - OYSTERS
KW - TOXINS
KW - ANALYTICAL chemistry
N1 - Accession Number: 24104394; Poli, Mark A. 1; Email Address: mark.poli@det.amedd.army.mil Rivera, Victor R. 1 Neal, Dwayne D. 1 Baden, Daniel G. 2 Messer, Shawn A. 3 Plakas, Steven M. 4 Dickey, Robert W. 4 El Said, Kathleen 4 Flewelling, Leanne 5 Green, David 6 White, Jill 7; Affiliation: 1: United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702-5011 2: University of North Carolina at Wilmington, Center for Marine Science, Wilmington, NC 28409 3: University of Iowa, College of Public Health, Iowa City, IA 52242 4: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528 5: Fish and Wildlife Research Institute, Florida Fish and Wildlife Conservation Commission, St. Petersburg, FL 33701 6: Mesoscale Diagnostics, LLC, 9238 Gaither Rd, Gaithersburg, MD 20877 7: BioVeris Corp., 16020 Industrial Dr, Gaithersburg, MD 20877; Source Info: Jan/Feb2007, Vol. 90 Issue 1, p173; Subject Term: CHEMILUMINESCENCE immunoassay; Subject Term: ANIMAL extracts; Subject Term: OYSTERS; Subject Term: TOXINS; Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Seong-Jae Kim
AU - Ohgew Kweon
AU - Jones, Richard C.
AU - Freeman, James P.
AU - Edmondson, Ricky D.
AU - Cerniglia, Carl E.
T1 - Complete and Integrated Pyrene Degradation Pathway in Mycobacterium vanbaalenii PYR-1 Based on Systems Biology.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2007/01//
VL - 189
IS - 1
M3 - Abstract
SP - 36
EP - 36
SN - 00219193
AB - Mycobacterium vanbaalenii PYR-1 was the first bacterium isolated by virtue of its ability to metabolize the high-molecular-weight polycyclic aromatic hydrocarbon (PAH) pyrene. We used metabolic, genomic, and proteomic approaches in this investigation to construct a complete and integrated pyrene degradation pathway for M. vanbaalenii PYR-1. Genome sequence analyses identified genes involved in the pyrene degradation pathway that we have proposed for this bacterium. To identify proteins involved in the degradation, we conducted a proteome analysis of cells exposed to pyrene using one-dimensional gel electrophoresis in combination with liquid chromatography-tandem mass spectrometry. Database searching performed with the M. vanbaalenii PYR-1 genome resulted in identification of 1,028 proteins with a protein false discovery rate of <1%. Based on both genomic and proteomic data, we identified 27 enzymes necessary for constructing a complete pathway for pyrene degradation. Our analyses indicate that this bacterium degrades pyrene to central intermediates through o-phthalate and the β-ketoadipate pathway. Proteomic analysis also revealed that 18 enzymes in the pathway were upregulated more than twofold, as indicated by peptide counting when the organism was grown with pyrene; three copies of the terminal subunits of ring-hydroxylating oxygenase (NidAB2, MvanDraft_0817/0818, and PhtAaAb), dihydrodiol dehydrogenase (MvanDraft_0815), and ring cleavage dioxygenase (MvanDraft_3242) were detected only in pyrene-grown cells. The results presented here provide a comprehensive picture of pyrene metabolism in M. vanbaalenii PYR-1 and a useful framework for understanding cellular processes involved in PAH degradation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM
KW - PYRENE (Chemical)
KW - GENES
KW - GEL electrophoresis
KW - LIQUID chromatography
KW - MASS spectrometry
KW - DATABASE searching
KW - PROTEINS
N1 - Accession Number: 23648539; Seong-Jae Kim 1 Ohgew Kweon 1 Jones, Richard C. 2 Freeman, James P. 3 Edmondson, Ricky D. 2 Cerniglia, Carl E. 1; Email Address: Carl.Cerniglia@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 2: Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 3: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079; Source Info: Jan2007, Vol. 189 Issue 1, p36; Subject Term: MYCOBACTERIUM; Subject Term: PYRENE (Chemical); Subject Term: GENES; Subject Term: GEL electrophoresis; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: DATABASE searching; Subject Term: PROTEINS; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1128/JB.01310-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peter PHH Hinderling
AU - Adel AHK Karara
AU - Ben BT Tao
AU - Maria MP Pawula
AU - Ian IW Wilding
AU - Ming ML Lu
T1 - Systemic Availability of the Active Metabolite Hydroxy-Fasudil After Administration of Fasudil to Different Sites of the Human Gastrointestinal Tract.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2007/01//
VL - 47
IS - 1
M3 - Article
SP - 19
EP - 25
SN - 00912700
AB - This study evaluated the gastrointestinal absorption of fasudil, a novel Rho kinase inhibitor for the treatment of stable angina, at different sites using remote-controlled capsules and assessed the feasibility of developing an extended-release formulation. Ten healthy male volunteers were enrolled, and 8 subjects completed this singledose, open-label, randomized, 5-way crossover study. Forty milligrams of fasudil HCl was administered as solution to the distal ileum and ascending colon, as powder to the ascending colon, and orally as an immediate-release tablet and solution. All treatments were well-tolerated and no serious adverse events were observed. The mean systemic availabilities of M3 relative to the oral solution were 1.04 (distal ileum, solution), 1.14 (ascending colon, solution), 1.27 (ascending colon, powder) and 1.04 (oral tablet), indicating similar systemic availability of M3 after administration of fasudil HCl to different gastrointestinal sites. The results suggest that development of a once-a-day extended-release formulation for fasudil HCl should be readily achievable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL drug trials
KW - ENZYME inhibitors
KW - INTESTINAL absorption
KW - GASTROINTESTINAL system
N1 - Accession Number: 24197844; Peter PHH Hinderling 1 Adel AHK Karara 2 Ben BT Tao 3 Maria MP Pawula 4 Ian IW Wilding 5 Ming ML Lu 2; Affiliation: 1: US Food and Drug Administration (FDA), Center for Drug Evaluation, Office of Clinical Pharmacology and Biopharmaceutics, Rockville, Maryland 2: Berlex Pharmaceuticals, Montville, New Jersey 3: Sankyo Pharma Development, Edison, New Jersey 4: Huntingdon Life Sciences, United Kingdom 5: Pharmaceutical Profiles Ltd, United Kingdom; Source Info: Jan2007, Vol. 47 Issue 1, p19; Subject Term: CLINICAL drug trials; Subject Term: ENZYME inhibitors; Subject Term: INTESTINAL absorption; Subject Term: GASTROINTESTINAL system; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roshni RPR Ramchandani
AU - Yaning YW Wang
AU - Brian BPB Booth
AU - Amna AI Ibrahim
AU - John JRJ Johnson
AU - Atiqur AR Rahman
AU - Mehul MM Mehta
AU - Federico FI Innocenti
AU - Mark MJR Ratain
AU - Jogarao JVG Gobburu
T1 - The Role of SN-38 Exposure, UGT1A1*28 Polymorphism, and Baseline Bilirubin Level in Predicting Severe Irinotecan Toxicity.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2007/01//
VL - 47
IS - 1
M3 - Article
SP - 78
EP - 86
SN - 00912700
AB - Irinotecan, an anticancer drug, is associated with severe and potentially fatal diarrhea and neutropenia. The objective of this analysis was to evaluate the role of SN-38 exposure, the active metabolite of irinotecan, UGT1A1 genotypes, and baseline bilirubin on the maximum decrease (nadir) in absolute neutrophil counts following irinotecan. This analysis extended the work of a previous study that examined the effect of UGT1A1 genotypes on the incidence of severe neutropenia in 86 advanced cancer patients following irinotecan treatment. Regression analysis showed that the absolute neutrophil count nadir depended on SN-38 exposure (AUC) and UGT1A1*28 homozygous 7/7 genotype. An increased SN-38 AUC and the 7/7 genotype were significantly associated with a lower absolute neutrophil count nadir (R2 = .49). An alternate model suggested that higher baseline bilirubin and the 7/7 genotype were also significantly associated with a lower absolute neutrophil count nadir, although with a lower coefficient of determination (R2= .31). Based on these findings and other reports, the irinotecan label was modified to indicate the role of UGT1A1*28 polymorphism in the metabolism of irinotecan and the associated increased risk of severe neutropenia. The label modifications also included recommendations for lower starting doses of irinotecan in patients homozygous for the UGT1A1*28 (7/7) polymorphism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - ANTINEOPLASTIC agents
KW - BILIRUBIN
KW - TOXICITY testing
N1 - Accession Number: 24197850; Roshni RPR Ramchandani 1 Yaning YW Wang 2 Brian BPB Booth 2 Amna AI Ibrahim 3 John JRJ Johnson 3 Atiqur AR Rahman 2 Mehul MM Mehta 2 Federico FI Innocenti 4 Mark MJR Ratain 4 Jogarao JVG Gobburu 2; Affiliation: 1: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, Maryland, roshni.ramchandani@fda.hhs.gov 2: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, Maryland 3: Office of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, Maryland 4: Department of Medicine, Committee on Clinical Pharmacology and Pharmacogenomics and Cancer Research Center, University of Chicago, Chicago, Illinois; Source Info: Jan2007, Vol. 47 Issue 1, p78; Subject Term: METABOLITES; Subject Term: ANTINEOPLASTIC agents; Subject Term: BILIRUBIN; Subject Term: TOXICITY testing; Number of Pages: 9p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24197850&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brian BPB Booth
AU - Atiqur AR Rahman
AU - Ramzi RD Dagher
AU - Donna DG Griebel
AU - Shari SL Lennon
AU - David DF Fuller
AU - Chandra CS Sahajwalla
AU - Mehul MM Mehta
AU - Jogarao JVG Gobburu
T1 - Population Pharmacokinetic-Based Dosing of Intravenous Busulfan in Pediatric Patients.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2007/01//
VL - 47
IS - 1
M3 - Article
SP - 101
EP - 111
SN - 00912700
AB - The objective of this study was to characterize the pharmacokinetics (PK) of intravenous busulfan in pediatric patients and provide dosing recommendations. Twenty-four pediatric patients were treated with intravenous busulfan, 1.0 or 0.8 mg/kg for ages ≤4 years or >4 years, respectively, 4 times a day for 4 days. Dense PK sampling was performed. Body weight, age, gender, and body surface area were explored for effects on PK, and Monte Carlo simulations were performed to assess different dosing regimens. The PK of intravenous busulfan was described by a 1-compartment model with clearance of 4.04 L/h/20 kg and volume of distribution of 12.8 L/20 kg. Simulations indicated that the mg/kg and mg/m 2 regimens were similar and achieved the desired target exposure in approximately 60% of patients. This model suggests that patients ≤12 kg should be dosed at 1.1 mg/kg and those >12 kg dosed at 0.8 mg/kg. Therapeutic drug monitoring and dose adjustment will further improve therapeutic targeting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG monitoring
KW - ANTINEOPLASTIC agents
KW - INTRAVENOUS therapy for children
KW - PHARMACOKINETICS
N1 - Accession Number: 24197855; Brian BPB Booth 1 Atiqur AR Rahman 1 Ramzi RD Dagher 2 Donna DG Griebel 3 Shari SL Lennon 4 David DF Fuller 5 Chandra CS Sahajwalla 1 Mehul MM Mehta 1 Jogarao JVG Gobburu 1; Affiliation: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Clinical Pharmacology 2: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Oncology Drug Products, Division of Drug Oncology Products 3: National Institutes of Health, National Cancer Institute, Division of Cancer Prevention, Gastrointestinal and Other Cancers Research Group 4: oncology and transplant, Minnesota 5: Genzyme Europe Research, Cambridge, United Kingdom; Source Info: Jan2007, Vol. 47 Issue 1, p101; Subject Term: DRUG monitoring; Subject Term: ANTINEOPLASTIC agents; Subject Term: INTRAVENOUS therapy for children; Subject Term: PHARMACOKINETICS; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105900342
T1 - The Role of SN-38 Exposure, UGT1A1*28 Polymorphism, and Baseline Bilirubin Level in Predicting Severe Irinotecan Toxicity.
AU - Ramchandani RP
AU - Wang Y
AU - Booth BP
AU - Ibrahim A
AU - Johnson JR
AU - Rahman A
AU - Mehta M
AU - Innocenti F
AU - Ratain MJ
AU - Gobburu JV
Y1 - 2007/01//
N1 - Accession Number: 105900342. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Alkaloids -- Analogs and Derivatives
KW - Antineoplastic Agents -- Metabolism
KW - Bilirubin -- Metabolism
KW - Lymphoma -- Drug Therapy
KW - Neutropenia -- Chemically Induced
KW - Polymorphism, Genetic
KW - Transferases
KW - Alkaloids -- Adverse Effects
KW - Alkaloids -- Metabolism
KW - Alkaloids -- Therapeutic Use
KW - Antineoplastic Agents -- Adverse Effects
KW - Antineoplastic Agents -- Therapeutic Use
KW - Female
KW - Lymphoma
KW - Male
KW - Models, Biological
KW - Pharmacokinetics
KW - Regression
KW - Human
SP - 78
EP - 86
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 47
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Irinotecan, an anticancer drug, is associated with severe and potentially fatal diarrhea and neutropenia. The objective of this analysis was to evaluate the role of SN-38 exposure, the active metabolite of irinotecan, UGT1A1 genotypes, and baseline bilirubin on the maximum decrease (nadir) in absolute neutrophil counts following irinotecan. This analysis extended the work of a previous study that examined the effect of UGT1A1 genotypes on the incidence of severe neutropenia in 86 advanced cancer patients following irinotecan treatment. Regression analysis showed that the absolute neutrophil count nadir depended on SN-38 exposure (AUC) and UGT1A1(*)28 homozygous 7/7 genotype. An increased SN-38 AUC and the 7/7 genotype were significantly associated with a lower absolute neutrophil count nadir (R(2) = .49). An alternate model suggested that higher baseline bilirubin and the 7/7 genotype were also significantly associated with a lower absolute neutrophil count nadir, although with a lower coefficient of determination (R(2) = .31). Based on these findings and other reports, the irinotecan label was modified to indicate the role of UGT1A1(*)28 polymorphism in the metabolism of irinotecan and the associated increased risk of severe neutropenia. The label modifications also included recommendations for lower starting doses of irinotecan in patients homozygous for the UGT1A1(*)28 (7/7) polymorphism.
SN - 0091-2700
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, WO21 Rm 3667, 10903 New Hampshire Ave, Silver Spring, MD 20993; e-mail: roshni.ramchandani@fda.hhs.gov.
U2 - PMID: 17192505.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105900345
T1 - Population pharmacokinetic-based dosing of intravenous busulfan in pediatric patients.
AU - Booth BP
AU - Rahman A
AU - Dagher R
AU - Griebel D
AU - Lennon S
AU - Fuller D
AU - Sahajwalla C
AU - Mehta M
AU - Gobburu JV
Y1 - 2007/01//
N1 - Accession Number: 105900345. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0366372.
KW - Alkylating Agents -- Pharmacokinetics
KW - Busulfan -- Pharmacokinetics
KW - Hematopoietic Stem Cell Transplantation
KW - Models, Biological
KW - Neoplasms -- Drug Therapy
KW - Age Factors
KW - Alkylating Agents -- Administration and Dosage
KW - Alkylating Agents -- Therapeutic Use
KW - Alkylating Agents
KW - Body Surface Area
KW - Body Weight
KW - Busulfan -- Administration and Dosage
KW - Busulfan -- Blood
KW - Busulfan -- Therapeutic Use
KW - Child
KW - Child, Preschool
KW - Clinical Trials
KW - Computer Simulation
KW - Dose-Response Relationship, Drug
KW - Female
KW - Injections, Intravenous
KW - Male
KW - Neoplasms -- Therapy
KW - Sex Factors
KW - Systems Analysis
KW - Human
SP - 101
EP - 111
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 47
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The objective of this study was to characterize the pharmacokinetics (PK) of intravenous busulfan in pediatric patients and provide dosing recommendations. Twentyfour pediatric patients were treated with intravenous busulfan, 1.0 or 0.8 mg/kg for ages 4 years, respectively, 4 times a day for 4 days. Dense PK sampling was performed. Body weight, age, gender, and body surface area were explored for effects on PK, and Monte Carlo simulations were performed to assess different dosing regimens. The PK of intravenous busulfan was described by a 1-compartment model with clearance of 4.04 L/h/20 kg and volume of distribution of 12.8 L/20 kg. Simulations indicated that the mg/kg and mg/m(2) regimens were similar and achieved the desired target exposure in approximately 60% of patients. This model suggests that patients 12 kg dosed at 0.8 mg/kg. Therapeutic drug monitoring and dose adjustment will further improve therapeutic targeting.
SN - 0091-2700
AD - Food and Drug Administration, Office of Clinical Pharmacology, Division of Clinical Pharmacology 5, 10903 New Hampshire Avenue, Building 21, Room 3668, Silver Spring, MD 20993-0002.
U2 - PMID: 17192508.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900345&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cohen, Steven B.
AU - Rhoades, Jeffrey A.
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, MD
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, MD
T1 - Estimation of the Long Term Uninsured in the Medical Expenditure Panel Survey
JO - Journal of Economic and Social Measurement
JF - Journal of Economic and Social Measurement
Y1 - 2007///
VL - 32
IS - 4
SP - 235
EP - 249
SN - 07479662
N1 - Accession Number: 0982912; Keywords: Health; Health Care; Insurance; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200807
N2 - This study provides a summary of the capacity of the Medical Expenditure Panel Survey (MEPS) to produce national estimates of the continuously uninsured population over a four year time frame and the adopted estimation strategy. The paper reports on the employed methodology that permits more accurate estimates of the long term uninsured than heretofore derived. This is accomplished through the linkage of the survey to the National Health Interview Survey, allowing for a reconciliation of insurance coverage responses covering overlapping time periods. The production of national estimates of the long term uninsured for a four year interval is a new MEPS output, and this study identifies the characteristics of the uninsured. The utility of this information to improve behavioral models of health care expenditure patterns is also described.
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://iospress.metapress.com/content/0747-9662/
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0982912&site=ehost-live&scope=site
UR - http://iospress.metapress.com/content/0747-9662/
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Richardson, David B.
AU - Wing, Steve
AU - Daniels, Robert D.
T1 - Evaluation of external radiation dosimetry records at the Savannah River Site, 1951–1989.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2007/01//
VL - 17
IS - 1
M3 - Article
SP - 13
EP - 24
PB - Nature Publishing Group
SN - 15590631
AB - The Savannah River Site (SRS) is one of the largest facilities in the nation's nuclear weapons complex. To date, little information has been published regarding radiation risk estimates derived from epidemiological studies of SRS workers. As part of an ongoing epidemiological cohort study of SRS workers, we have assessed the suitability of the Site's personnel radiation dosimetry information for use in epidemiological analyses. This paper provides information on historical dosimetry methods, recording practices, and the completeness of computerized dosimetry information for workers employed at SRS during the period 1951–1989, when the site was operated by the du Pont Company. The study includes 18,883 workers hired at SRS between 1951 and 1987 who were employed for at least 90 days. Documents relating to external radiation dosimetry methods were reviewed, recorded doses were examined to evaluate recording practices, and the completeness of monitoring was assessed by comparing employment history and computerized dosimetry records, and by implementing a “nearby” procedure for estimating values for missing annual dosimetry records. Dosimeter technology evolved over this period from two-element film dosimeters to multielement thermoluminescent dosimeters. Dosimetry measurements were recorded consistently in 0.05 millisievert (mSv) increments. Prior to 1973, recording thresholds of 0.10–0.15 mSv were used while from 1973 to 1989 a recording threshold of 0.05 mSv was used. We abstracted nearly 3 person-Sv of dosimetry information that was available in hardcopy but not in computerized format. The collective dose from the computerized and abstracted records totaled 512.1 person-Sv. A “nearby” method was used to estimate dose values for 13,812 employment-years for which dosimetry information was not available. The average estimated value was 0.6 mSv and the assigned collective dose derived via the “nearby” procedure was 8.7 person-Sv. The consistency of dosimetry practices at SRS and the completeness of historical dosimetry records are supportive of their use in epidemiologic research.Journal of Exposure Science and Environmental Epidemiology (2007) 17, 13–24. doi:10.1038/sj.jes.7500515; published online 28 June 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION
KW - RADIATION dosimetry
KW - NUCLEAR weapons plants
KW - EPIDEMIOLOGY
KW - EMPLOYEES
KW - SAVANNAH River Site (S.C.)
KW - SOUTH Carolina
KW - dosimetry
KW - radiation
KW - Savannah River Site
N1 - Accession Number: 24349637; Richardson, David B. 1; Email Address: david.richardson@unc.edu Wing, Steve 1 Daniels, Robert D. 2; Affiliation: 1: Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2: Health-related Energy Research Branch, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA; Source Info: Jan2007, Vol. 17 Issue 1, p13; Subject Term: RADIATION; Subject Term: RADIATION dosimetry; Subject Term: NUCLEAR weapons plants; Subject Term: EPIDEMIOLOGY; Subject Term: EMPLOYEES; Subject Term: SAVANNAH River Site (S.C.); Subject Term: SOUTH Carolina; Author-Supplied Keyword: dosimetry; Author-Supplied Keyword: radiation; Author-Supplied Keyword: Savannah River Site; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 12p; Illustrations: 6 Charts, 4 Graphs; Document Type: Article
L3 - 10.1038/sj.jes.7500515
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24349637&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Merenstein, Dan
AU - Meyers, David
AU - Krist, Alex
AU - Delgado, Jose
AU - McCann, Jessica
AU - Petterson, Stephen
AU - Phillips Jr., Robert L.
T1 - How well do family physicians manage skin lesions?
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2007/01//
VL - 56
IS - 1
M3 - Article
SP - 40
EP - 45
PB - Frontline Medical Communications
SN - 00943509
AB - The article investigates the efficiency of family physicians in managing cases involving skin lesions. The researchers conducted a prospective cohort study to compare family physicians with dermatologists. Studies have evaluated the skill level of primary care physicians compared with dermatologists in identifying skin disorders. The results of the study indicate that family physicians are at par with dermatologists in managing skin lesions. Experts recommend for practitioners to feel comfortable knowing that most patients whom they treat with skin disorders improve.
KW - SKIN diseases
KW - PHYSICIANS (General practice)
KW - PRIMARY care (Medicine)
KW - COHORT analysis
KW - FAMILY medicine
KW - DERMATOLOGISTS
KW - CORE competencies
KW - MEDICINE -- Specialties & specialists
KW - MEDICINE -- Practice
N1 - Accession Number: 23803907; Merenstein, Dan 1,2; Email Address: djm23@georgetown.edu Meyers, David 2,3 Krist, Alex 4 Delgado, Jose 2 McCann, Jessica 2,5 Petterson, Stephen 5 Phillips Jr., Robert L. 2,5; Affiliation: 1: Robert Wood Johnson Clinical Scholars Program, Johns Hopkins School of Medicine, Baltimore, Md 2: Department of Family Medicine, Georgetown University, Washington, DC 3: US Department of Health and Human Services, Agency for Healthcare Research and Quality, Bethesda, Md 4: Department of Family Medicine, Fairfax Family Practice Residency, Virginia Commonwealth University, Richmond 5: Robert Graham Center for Policy Studies, Family Medicine and Primary Care, Washington, DC; Source Info: Jan2007, Vol. 56 Issue 1, p40; Subject Term: SKIN diseases; Subject Term: PHYSICIANS (General practice); Subject Term: PRIMARY care (Medicine); Subject Term: COHORT analysis; Subject Term: FAMILY medicine; Subject Term: DERMATOLOGISTS; Subject Term: CORE competencies; Subject Term: MEDICINE -- Specialties & specialists; Subject Term: MEDICINE -- Practice; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kinde, Hailu
AU - Mikolon, Andrea
AU - Rodriguez-Lainz, Alfonso
AU - Adams, Cathy
AU - Walker, Richard L.
AU - Cernek-Hoskins, Shannon
AU - Treviso, Scarlett
AU - Ginsberg, Michele
AU - Rast, Robert
AU - Harris, Beth
AU - Payeur, Janet B.
AU - Waterman, Steve
AU - Ardans, Alex
T1 - Recovery of Salmonella, Listeria monocytogenes, and Mycobacterium bovis from Cheese Entering the United States through a Noncommercial Land Port of Entry.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/01//
VL - 70
IS - 1
M3 - Article
SP - 47
EP - 52
SN - 0362028X
AB - A joint multiagency project was initiated in response to a Salmonella outbreak in San Diego County, California, in 2004. Samples of cheese were collected during four 1-day operations at the San Ysidro port of entry, along the United States-Mexico border. Surveyed participants were persons crossing the border as pedestrians or in vehicles who had a minimum of 2.27 kg of cheese, which may suggest a potential diversion to illegal marketing. In addition, data were collected about the cheese to identify risk factors for cheese contamination. Two hundred four cheese samples were submitted to the California Animal Health and Food Safety Laboratory System-San Bernardino Branch and analyzed for potential food pathogens. Ninety-four percent (190 of 203) of the samples tested positive for alkaline phosphatase. Salmonella was detected from 13% (27 of 204) of the samples comprising 11 serogroups and 28 serotypes. Pulsed-field gel electrophoresis DNA fingerprinting analysis, performed following standardized methods, determined that an isolate obtained from this study had an indistinguishable pattern from a recent Salmonella enterica serovar Typhimurium var. Copenhagen epidemic in the San Diego County that was linked to 14 illnesses. Listeria spp. were detected from 4% (8 of 204) of the samples, and of these, half were identified as L. monocytogenes. Escherichia coli O157:H7 was not detected from any of the samples. Mycobacterium bovis was detected from one panela-style cheese sample. Nine additional samples yielded Mycobacterium spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Food adulteration & inspection
KW - Dairy products -- Contamination
KW - DNA fingerprinting
KW - Food pathogens
KW - Cheese products
KW - Pulsed-field gel electrophoresis
KW - Salmonella diseases
KW - Salmonella food poisoning
KW - Listeria monocytogenes
KW - Ports of entry
N1 - Accession Number: 23693546; Kinde, Hailu 1,2; Email Address: hkinde@ucdavis.edu; Mikolon, Andrea 3; Rodriguez-Lainz, Alfonso 4; Adams, Cathy 5; Walker, Richard L. 6; Cernek-Hoskins, Shannon 4; Treviso, Scarlett 3; Ginsberg, Michele 7; Rast, Robert 8; Harris, Beth 9; Payeur, Janet B. 9; Waterman, Steve 10; Ardans, Alex 6; Affiliations: 1: California Animal Health and Food Safety Laboratory System (CAHFS), San Bernardino Branch, 105 West Central Avenue, San Bernardino, California 92408; 2: School of Veterinary Medicine, University of California, Davis, California 95616; 3: Animal Health & Food Safety Services Division, California Department of Food and Agriculture, 1220 North Street, Sacramento, California 95814; 4: California Office of Binational Border Health, California Department of Health Services, 3851 Rosecrans Street, San Diego, California 92138; 5: San Diego County Public Health Laboratory, 3851 Rosecrans Street, San Diego, California 92110; 6: CAHFS-Davis, Health Sciences Drive, School of Veterinary Medicine, University of California, Davis, California 95616; 7: Community Epidemiology Division, County of San Diego Health and Human Services, 1700 Pacific Highway, San Diego, California 92186; 8: U.S. Food and Drug Administration, 2320 Paseo De Las Americas Suite 200, San Diego, California 92154; 9: U.S. Department of Agriculture, Animal and Plant Health Inspection Services, National Veterinary Services Laboratories, 1810 Dayton Avenue, Ames, Iowa 50010, USA; 10: Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, 3851 Rosecrans Street, San Diego, California 92138, USA; Issue Info: Jan2007, Vol. 70 Issue 1, p47; Thesaurus Term: Food contamination; Thesaurus Term: Food adulteration & inspection; Thesaurus Term: Dairy products -- Contamination; Thesaurus Term: DNA fingerprinting; Thesaurus Term: Food pathogens; Subject Term: Cheese products; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Salmonella diseases; Subject Term: Salmonella food poisoning; Subject Term: Listeria monocytogenes; Subject Term: Ports of entry; NAICS/Industry Codes: 311513 Cheese Manufacturing; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mihee Cho
AU - Yoonjung Choi
AU - Hyojin Park
AU - Kwansik Kim
AU - Gun-Jo Woo
AU - Jiyong Park
T1 - Titanium Dioxide/UV Photocatalytic Disinfection in Fresh Carrots.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/01//
VL - 70
IS - 1
M3 - Article
SP - 97
EP - 101
SN - 0362028X
AB - Increased occurrences of fresh produce-related outbreaks of foodborne illness have focused attention on effective washing processes for fruits and vegetables. A titanium dioxide (TiO2) photocatalytic reaction under UV radiation provides a high rate of disinfection. The photo-killing effects of TiO2 on bacteria in liquid cultures under experimental conditions have been widely studied. However, the disinfection effects of the TiO2 photocatalytic reaction on fresh vegetables during a washing process have not been evaluated. Our objectives were to design a pilot-scale TiO2/UV photocatalytic reactor for fresh carrots and to compare the bactericidal effects of the TiO2/UV reaction against bacteria in liquid media and on carrots. TiO2/UV photocatalytic reactions for 40, 60, and 30 s were required for the complete killing of Escherichia coli, Salmonella Typhimurium, and Bacillus cereus (initial counts of approximately 6.7 log CFU/ml), respectively. The counts of total aerobic bacteria in fresh carrots and foodborne pathogenic bacteria in inoculated carrots were also measured. Counts of total aerobic bacteria were reduced by 1.8 log CFU/g after TiO2/UV photocatalytic disinfection for 20 min compared with a 1.1-log CFU/g reduction by UV alone. E. coli, Salmonella Typhimurium, and B. cereus (8 log CFU/ml) were inoculated onto carrots, and the number of surviving bacteria in carrots was determined after treatment. The TiO2/UV treatment exhibited 2.1-, 2.3-, and 1.8-log CFU/g reductions in the counts of E. coli, Salmonella Typhimurium, and B. cereus, respectively, compared with 1.3-, 1.2-, and 1.2-log CFU/g reductions by UV alone. The TiO2/UV photocatalyst reaction showed significant bactericidal effects, indicating that this process is applicable to nonthermal disinfection of fresh vegetables. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Farm produce
KW - Fruit -- Contamination
KW - Food contamination
KW - Vegetables -- Contamination
KW - Pathogenic bacteria
KW - RESEARCH
KW - Titanium diboride
KW - Carrots
KW - Salmonella typhimurium
N1 - Accession Number: 23693553; Mihee Cho 1; Yoonjung Choi 1; Hyojin Park 1; Kwansik Kim 1; Gun-Jo Woo 2; Jiyong Park 1; Email Address: foodpro@yonsei.ac.kr; Affiliations: 1: Department of Biotechnology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea; 2: Center for Food Safety Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea; Issue Info: Jan2007, Vol. 70 Issue 1, p97; Thesaurus Term: Foodborne diseases; Thesaurus Term: Farm produce; Thesaurus Term: Fruit -- Contamination; Thesaurus Term: Food contamination; Thesaurus Term: Vegetables -- Contamination; Thesaurus Term: Pathogenic bacteria; Thesaurus Term: RESEARCH; Subject Term: Titanium diboride; Subject Term: Carrots; Subject Term: Salmonella typhimurium; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 493130 Farm Product Warehousing and Storage; Number of Pages: 5p; Illustrations: 1 Diagram, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shieh, Y. C.
AU - Khudyakov, Y. E.
AU - Xia, G.
AU - Ganova-Raeva, L. M.
AU - Khambaty, F. M.
AU - Woods, J. W.
AU - Veazey, J. E.
AU - Motes, M. L.
AU - Glatzer, M. B.
AU - Bialek, S. R.
AU - Fiore, A. E.
T1 - Molecular Confirmation of Oysters as the Vector for Hepatitis A in a 2005 Multistate Outbreak.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/01//
VL - 70
IS - 1
M3 - Article
SP - 145
EP - 150
SN - 0362028X
AB - Numerous hepatitis A outbreaks were linked to the consumption of raw molluscan shellfish in the United States between 1960 and 1989. However, there had been no major molluscan shellfish-associated hepatitis A outbreaks reported in the United States for more than a decade (1989 to 2004). Beginning in late August 2005, at least 10 clusters of hepatitis A illnesses, totaling 39 persons, occurred in four states among restaurant patrons who ate oysters. Epidemiologic data indicated that oysters were the source of the outbreak. Traceback information showed that the implicated oysters were harvested from specific Gulf Coast areas. A voluntary recall of oysters was initiated in September. Hepatitis A virus (HAV) was detected in multiple 25-g portions in one of two recalled samples, indicating that as many as 1 of every 15 oysters from this source was contaminated. Comparing 315 nucleotides within the HAV VP1-2B region, 100% homology was found among four amplicons recovered from a total of six independent experiments of the implicated oysters, and an identical HAV sequence was detected in sera from all 28 patient serum specimens tested. Ten percent heterogeneity over 315 nucleotides (31 variants) was observed between the outbreak strain (subgenotype 1A) and an HM-175 strain (subgenotype 1B) used in the laboratory where the oysters were processed. To our knowledge, this investigation is the first in the United States to identify an HAV-identical strain in persons with hepatitis A as well as in the food that was implicated as the source of their infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Shellfish as food -- Contamination
KW - Oysters -- Contamination
KW - Food contamination
KW - Food adulteration & inspection
KW - Hepatitis A
KW - Nucleotides
KW - United States
N1 - Accession Number: 23693560; Shieh, Y. C. 1; Email Address: carol.shieh@fda.hhs.gov; Khudyakov, Y. E. 2; Xia, G. 2; Ganova-Raeva, L. M. 2; Khambaty, F. M. 1; Woods, J. W. 1; Veazey, J. E. 3; Motes, M. L. 4; Glatzer, M. B. 5; Bialek, S. R. 2; Fiore, A. E. 2; Affiliations: 1: U.S. Food and Drug Administration Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528; 2: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; 3: U.S. Food and Drug Administration, Office of Regulatory Affairs, Baton Rouge, Louisiana 70809; 4: U.S. Food and Drug Administration, Office of Regulatory Affairs, Mobile, Alabama 36606; 5: U.S. Food and Drug Administration, Office of Regulatory Affairs, Tallahassee, Florida 32301, USA; Issue Info: Jan2007, Vol. 70 Issue 1, p145; Thesaurus Term: Shellfish as food -- Contamination; Thesaurus Term: Oysters -- Contamination; Thesaurus Term: Food contamination; Thesaurus Term: Food adulteration & inspection; Subject Term: Hepatitis A; Subject Term: Nucleotides; Subject: United States; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Treasure, Tom
AU - Sedrakyan, Artyom
T1 - Surgeons may have introduced a new operative technique in African-American patients.
JO - Journal of Health Services Research & Policy
JF - Journal of Health Services Research & Policy
Y1 - 2007/01//
VL - 12
IS - 1
M3 - Article
SP - 2
EP - 3
SN - 13558196
AB - The author reflects on an article by Mukamel and colleagues that examined several explanations of differences in the utilization rates of a newly reintroduced technique, off-pump coronary artery bypass grafting (CABG), between racial minorities and Whites in New York City. Several details related to the history of the CABG method, racial aspects and complex factors involved in clinical decision-making in the management of patients undergoing cardiac surgery are also discussed.
KW - CORONARY artery bypass
KW - TRANSPLANTATION of organs, tissues, etc.
KW - RACIAL minorities
KW - AFRICAN Americans -- Health
KW - OPERATIVE surgery
KW - CARDIOLOGISTS
KW - EDITORIALS
KW - NEW York (State)
N1 - Accession Number: 23686883; Treasure, Tom 1 Sedrakyan, Artyom 2; Affiliation: 1: Guy's Hospital, St Thomas's Street, London SE1 9RT, UK 2: Agency for Healthcare Research and Quality, US Department of Health & Human Services, Rockville, MD, USA; Source Info: Jan2007, Vol. 12 Issue 1, p2; Subject Term: CORONARY artery bypass; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: RACIAL minorities; Subject Term: AFRICAN Americans -- Health; Subject Term: OPERATIVE surgery; Subject Term: CARDIOLOGISTS; Subject Term: EDITORIALS; Subject Term: NEW York (State); NAICS/Industry Codes: 519110 News Syndicates; Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1258/135581907779497639
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Stacey E.
AU - Meade, B. Jean
AU - Butterworth, Leon F.
AU - Munson, Albert E.
T1 - The Humoral Immune Response of Mice Exposed to Manual Metal Arc Stainless Steel-Welding Fumes.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2007/01//Jan-Mar2007
VL - 4
IS - 1
M3 - Article
SP - 15
EP - 23
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Arc welding is one of the most common forms of welding and includes the use of stainless steel electrodes that emit fumes containing chromium and nickel. Epidemological studies suggest a correlation between arc welding and adverse respiratory health effects. Studies evaluating the immunotoxic effects of welding fumes are limited due to the large number of variables associated with welding. This work investigates the immunotoxic effects of welding fumes by analyzing the in vivo and in vitro IgM response to a T-dependent antigen after welding fume exposure. Significant decreases in the total IgM activity/106 viable cells and total IgM activity/well were observed in splenocytes exposed to 5 μ g/ml of either total or soluble welding fumes. A significant reduction in the specific IgM activity in lung associated lymph node cells was also observed following four pharyngeal aspirations of 10 mg/kg total or soluble welding fumes to mice. Significant elevations in the absolute lymph node cell numbers for both B- and T-cells including the CD4+ and CD8+ subsets were observed. These results demonstrate that exposure to manual metal-stainless steel welding fumes is immunosuppressive in the presence of increased lymphoctye numbers in mice and raises concerns regarding the potential for adverse immunological effects to impact respiratory health in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Epidemiology -- Research
KW - Chromium
KW - Nickel
KW - Electric welding -- Electrodes
KW - Respiratory diseases
KW - humoral immune response
KW - immunosuppression
KW - MMA-SS welding fumes
N1 - Accession Number: 24154999; Anderson, Stacey E. 1; Email Address: sanderson4@cdc.gov; Meade, B. Jean 1; Butterworth, Leon F. 1; Munson, Albert E. 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia; Issue Info: Jan-Mar2007, Vol. 4 Issue 1, p15; Thesaurus Term: Immune response; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: Chromium; Thesaurus Term: Nickel; Subject Term: Electric welding -- Electrodes; Subject Term: Respiratory diseases; Author-Supplied Keyword: humoral immune response; Author-Supplied Keyword: immunosuppression; Author-Supplied Keyword: MMA-SS welding fumes; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 9p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15476910601115119
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Benfeldt, Eva
AU - Hansen, Steen H.
AU - Vølund, Aage
AU - Menné, Torkil
AU - Shah, Vinod P.
T1 - Bioequivalence of Topical Formulations in Humans: Evaluation by Dermal Microdialysis Sampling and the Dermatopharmacokinetic Method.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2007/01//
VL - 127
IS - 1
M3 - Article
SP - 170
EP - 178
SN - 0022202X
AB - The aim of this study was to evaluate the relationship between dermal microdialysis (DMD) sampling and the dermatopharmacokinetic method when employed simultaneously for bioequivalence (BE) investigations of topical formulations. Topical lidocaine cream and ointment (both 5%) was investigated in eight healthy human volunteers (four male, four female). On one forearm, four microdialysis probes in two penetration areas sampled for 5 hours, and on the other arm, tape stripping was performed 30 and 120 minutes after product application. Lidocaine content in samples was analyzed by HPLC–mass spectrometry. The two methods were in agreement showing 3- to 5-fold higher lidocaine penetration from cream formulation than from ointment. A rank-order correlation between the two methods was demonstrated for lidocaine contents in microdialysates versus tape strip at 120 minutes, significant for the ointment formulation and for both formulations analyzed together. Analysis of variance demonstrated reproducible lidocaine concentrations in microdialysates with an intrasubject variability of 19% between probes and 20% between the two penetration areas. Thus, intersubject variability accounted for 61% of the variance. DMD sampling proved effective and variability analyses demonstrated the feasibility of BE studies in as little as 18 subjects.Journal of Investigative Dermatology (2007) 127, 170–178. doi:10.1038/sj.jid.5700495; published online 27 July 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Therapeutic equivalency
KW - PHARMACOKINETICS
KW - OINTMENTS
KW - DERMATOLOGIC agents
KW - LIDOCAINE
KW - DERMATOLOGY
N1 - Accession Number: 23421438; Benfeldt, Eva 1; Email Address: benfeldt@post5.tele.dk Hansen, Steen H. 2 Vølund, Aage 3 Menné, Torkil 1 Shah, Vinod P. 4; Affiliation: 1: Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark 2: Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark 3: Department of Biostatistics, Novo Nordisk A/S, Bagsvaerd, Denmark 4: Office of Pharmaceutical Science, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jan2007, Vol. 127 Issue 1, p170; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: PHARMACOKINETICS; Subject Term: OINTMENTS; Subject Term: DERMATOLOGIC agents; Subject Term: LIDOCAINE; Subject Term: DERMATOLOGY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 9p; Illustrations: 1 Color Photograph, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1038/sj.jid.5700495
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moyer, Ernest S.
AU - Commodore, Michael A.
AU - Hayes, Jeffrey L.
AU - Fotta, Steven A.
AU - Berardinelli, Jr., Stephen P.
T1 - Real-Time Evaluation of Ventilation Filter-Bank Systems.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/01//
VL - 4
IS - 1
M3 - Article
SP - 58
EP - 69
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study evaluated two government facility ventilation systems. One was a metropolitan government office complex with a recirculation system where outside air was the makeup air; the other was a NIOSH facility that used 100% outside air with no recirculation. The methodology employed was a modified American Society of Agricultural Engineers standard (S525) for testing total enclosure filtration efficiency, in agricultural tractor cabs, with optical particle counters (OPC). The low-efficiency bag filters were tested when new and after being in the ventilation system for 3 months. The replacement medium-efficiency filters were evaluated for 6 months (the manufacturer's suggested change-out schedule). These eight-chamber, medium-efficiency filters had an increased filter surface area that resulted in increased airflow through the system. Unfortunately, these filters contained electrostatic filter media and lost filtration efficiency rapidly, which was subsequently confirmed in a 30-day study conducted to determine an appropriate change-out schedule for the eight-chamber bag filters. The study determined that less than 6 months' use was justified due to the reduced efficiency of the electrostatic filter media. The NIOSH facility's air handler #8 (100% outside air unit) was upgraded from electrostatic bag filters, which had a suggested 9-month change-out schedule, to V Bank mechanical, wet-laid, glass fiber filters. The results of a 3-year evaluation showed that the V Bank filters had better filter efficiency after 3 years of service than the electrostatic filters had at 9 months. Both studies employed matched OPC instruments to reduce instrument-to-instrument bias. The methodology is adaptable to monitoring the total efficiency of most air filtration systems, and results can help make decisions about upgrading filter performance [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Indoor air pollution
KW - Air purification equipment industry
KW - Dust -- Measurement
KW - Ventilation -- Management
KW - Gases -- Filtration
KW - Office buildings -- Maintenance & repair
KW - Offices -- Environmental conditions
KW - Dust control -- Equipment & supplies
KW - aerosol particles
KW - control technology
KW - filtration
KW - indoor environment
KW - optical particle counter
KW - ventilation systems
N1 - Accession Number: 23332251; Moyer, Ernest S. 1; Email Address: esm2@cdc.gov; Commodore, Michael A. 1; Hayes, Jeffrey L. 1; Fotta, Steven A. 2; Berardinelli, Jr., Stephen P. 3; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Division of Respiratory Disease Studies, Laboratory Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office of Administrative and Management Services, Administrative Services Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 3: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Fatality Investigation Team, Morgantown, West Virginia; Issue Info: Jan2007, Vol. 4 Issue 1, p58; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Indoor air pollution; Thesaurus Term: Air purification equipment industry; Subject Term: Dust -- Measurement; Subject Term: Ventilation -- Management; Subject Term: Gases -- Filtration; Subject Term: Office buildings -- Maintenance & repair; Subject Term: Offices -- Environmental conditions; Subject Term: Dust control -- Equipment & supplies; Author-Supplied Keyword: aerosol particles; Author-Supplied Keyword: control technology; Author-Supplied Keyword: filtration; Author-Supplied Keyword: indoor environment; Author-Supplied Keyword: optical particle counter; Author-Supplied Keyword: ventilation systems; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 333413 Industrial and Commercial Fan and Blower and Air Purification Equipment Manufacturing; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 335210 Small Electrical Appliance Manufacturing; Number of Pages: 12p; Illustrations: 1 Black and White Photograph, 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620601079642
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23332251&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106113514
T1 - Real-time evaluation of ventilation filter-bank systems.
AU - Moyer ES
AU - Commodore MA
AU - Hayes JL
AU - Fotta SA
AU - Berardinelli SP Jr.
Y1 - 2007/01//
N1 - Accession Number: 106113514. Language: English. Entry Date: 20070706. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; exam questions; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Conditioning -- Equipment and Supplies
KW - Air Pollutants -- Analysis
KW - Air Pollution, Indoor -- Prevention and Control
KW - Particulate Matter -- Analysis
KW - Ventilation -- Equipment and Supplies
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Electricity
KW - Equipment Design
KW - Filtration -- Equipment and Supplies
KW - Human
SP - 58
EP - 6
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study evaluated two government facility ventilation systems. One was a metropolitan government office complex with a recirculation system where outside air was the makeup air; the other was a NIOSH facility that used 100% outside air with no recirculation. The methodology employed was a modified American Society of Agricultural Engineers standard (S525) for testing total enclosure filtration efficiency, in agricultural tractor cabs, with optical particle counters (OPC). The low-efficiency bag filters were tested when new and after being in the ventilation system for 3 months. The replacement medium-efficiency filters were evaluated for 6 months (the manufacturer's suggested change-out schedule). These eight-chamber, medium-efficiency filters had an increased filter surface area that resulted in increased airflow through the system. Unfortunately, these filters contained electrostatic filter media and lost filtration efficiency rapidly, which was subsequently confirmed in a 30-day study conducted to determine an appropriate change-out schedule for the eight-chamber bag filters. The study determined that less than 6 months' use was justified due to the reduced efficiency of the electrostatic filter media. The NIOSH facility's air handler #8 (100% outside air unit) was upgraded from electrostatic bag filters, which had a suggested 9-month change-out schedule, to V Bank mechanical, wet-laid, glass fiber filters. The results of a 3-year evaluation showed that the V Bank filters had better filter efficiency after 3 years of service than the electrostatic filters had at 9 months. Both studies employed matched OPC instruments to reduce instrument-to-instrument bias. The methodology is adaptable to monitoring the total efficiency of most air filtration systems, and results can help make decisions about upgrading filter performance
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Division of Respiratory Disease Studies, Laboratory Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia
U2 - PMID: 17162482.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, D. R.
AU - Leggat, P. A.
T1 - An international review of tobacco smoking among medical students.
JO - Journal of Postgraduate Medicine
JF - Journal of Postgraduate Medicine
Y1 - 2007/01//Jan-Mar2007
VL - 53
IS - 1
M3 - Article
SP - 55
EP - 62
PB - Medknow Publications & Media Pvt. Ltd.
SN - 00223859
AB - We conducted a systematic international review of tobacco smoking habits among medical students. Particular attention was paid to countries where smoking rates have been historically well-documented in local journals, but were less often included in larger international review articles. The methodology involved a search of relevant medical subject headings, after which the reference lists of journal papers were also examined to find additional publications. A total of 66 manuscripts met the inclusion criteria. The most common countries previously studied included India, the United States, Australia, Japan, Pakistan, Turkey and the United Kingdom. Overall, our review suggests that the prevalence of smoking among medical students varies widely amongst different countries and also between male and female students within the same areas. Consistently low smoking rates were found in Australia and the United States, while generally high rates were reported in Spain and Turkey. Given their important future role as exemplars, more effective measures to help reduce tobacco smoking among medical students are clearly needed worldwide. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Postgraduate Medicine is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING
KW - TOBACCO use
KW - MEDICAL students
KW - CIGARETTE smokers
KW - MEDICAL education
KW - SMOKING cessation
N1 - Accession Number: 23898709; Smith, D. R. 1,2; Email Address: smith@h.jniosh.go.jp Leggat, P. A. 2; Affiliation: 1: Japan National Institute of Occupational Safety and Health, Kawasaki, Japan 2: Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Australia; Source Info: Jan-Mar2007, Vol. 53 Issue 1, p55; Subject Term: SMOKING; Subject Term: TOBACCO use; Subject Term: MEDICAL students; Subject Term: CIGARETTE smokers; Subject Term: MEDICAL education; Subject Term: SMOKING cessation; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105916632
T1 - An international review of tobacco smoking among medical students.
AU - Smith DR
AU - Leggat PA
Y1 - 2007/01//Jan-Mar2007
N1 - Accession Number: 105916632. Language: English. Entry Date: 20080104. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Asia; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. NLM UID: 2985196R.
KW - Smoking -- Epidemiology
KW - Students, Medical
KW - Female
KW - Geographic Factors
KW - Male
KW - Meta Analysis
KW - PubMed
KW - Sex Factors
KW - Human
SP - 55
EP - 62
JO - Journal of Postgraduate Medicine
JF - Journal of Postgraduate Medicine
JA - J POSTGRAD MED
VL - 53
IS - 1
PB - Medknow Publications & Media Pvt. Ltd.
AB - We conducted a systematic international review of tobacco smoking habits among medical students. Particular attention was paid to countries where smoking rates have been historically well-documented in local journals, but were less often included in larger international review articles. The methodology involved a search of relevant medical subject headings, after which the reference lists of journal papers were also examined to find additional publications. A total of 66 manuscripts met the inclusion criteria. The most common countries previously studied included India, the United States, Australia, Japan, Pakistan, Turkey and the United Kingdom. Overall, our review suggests that the prevalence of smoking among medical students varies widely amongst different countries and also between male and female students within the same areas. Consistently low smoking rates were found in Australia and the United States, while generally high rates were reported in Spain and Turkey. Given their important future role as exemplars, more effective measures to help reduce tobacco smoking among medical students are clearly needed worldwide.
SN - 0022-3859
AD - Japan National Institute of Occupational Safety and Health, Kawasaki, Japan; smith@h.jniosh.go.jp.
U2 - PMID: 17244976.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105916632&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vipperman, Jeffrey S.
AU - Bauer, Eric R.
AU - Babich, Daniel R.
T1 - Survey of noise in coal preparation plants.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2007/01//
VL - 121
IS - 1
M3 - Article
SP - 197
EP - 205
SN - 00014966
AB - In response to the continuing problem of noise induced hearing loss (NIHL) among mine workers, the National Institute for Occupational Safety and Health (NIOSH) has conducted numerous noise surveys in coal preparation plants. The research, consisting of worker dose monitoring, task observations, and equipment noise profiling, was completed in eight separate preparation plants. Worker dose monitoring was conducted for three shifts in most cases. Workers experiencing higher than allowable doses were task-observed for one full shift to correlate dose to noise source(s). Finally, noise levels on all floors, and in lunch rooms and control rooms, were characterized. Results indicate that only workers who routinely spend a significant portion of their shift in the plants (away from the control rooms) are susceptible to overexposure from noise. Certain pieces of equipment (screens, centrifuges, sieve bends) are the loudest primary noise sources responsible for the worker noise exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOISE-induced deafness
KW - NOISE -- Physiological effect
KW - DEAFNESS
KW - COAL preparation plants
KW - NOISE -- Measurement
KW - INDUSTRIAL noise
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 23762308; Vipperman, Jeffrey S. 1; Email Address: jsv@pitt.edu Bauer, Eric R. 1 Babich, Daniel R. 2; Affiliation: 1: Department of Mechanical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 2: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236; Source Info: Jan2007, Vol. 121 Issue 1, p197; Subject Term: NOISE-induced deafness; Subject Term: NOISE -- Physiological effect; Subject Term: DEAFNESS; Subject Term: COAL preparation plants; Subject Term: NOISE -- Measurement; Subject Term: INDUSTRIAL noise; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 212116 Lignite coal mining; NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 212210 Iron Ore Mining; NAICS/Industry Codes: 212111 Bituminous Coal and Lignite Surface Mining; NAICS/Industry Codes: 212113 Anthracite Mining; Number of Pages: 9p; Illustrations: 4 Charts, 8 Graphs; Document Type: Article
L3 - 10.1121/1.2372587
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23762308&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Timothy T.
AU - Finlayson, Tracy L.
AU - Richard M. Scheffler
T1 - How do we measure shortages of dental hygienists and dental assistants?
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2007/01//
VL - 138
IS - 1
M3 - Article
SP - 94
EP - 100
SN - 00028177
AB - The article cites a study on the examination of labor market to determine a shortage of registered dental hygienists (RDHs) and dental assistants (DAs) in the U.S. The method used economic indicator that represents economic framework to investigate the trends in labor force and market wages for RDHs and DAs. Increase in wages of 48% indicates that labor shortage happen in both markets and enables dental professionals to react efficiently in market signals.
KW - DENTAL hygienists
KW - DENTAL assistants
KW - DENTISTS
KW - SUPPLY & demand
KW - UNITED States
KW - dental assistants
KW - Dental hygienists
KW - labor shortage
N1 - Accession Number: 23737105; Brown, Timothy T. 1; Email Address: hpetris@berkeley.edu Finlayson, Tracy L. 2 Richard M. Scheffler 3,4; Affiliation: 1: Associate Director, Research, Nicholas C. Penis Center on Health Care Markets and Consumer Welfare, School of Public Health, University of California, Berkeley, 140 Earl Warren Hall, MC7360, Berkeley. Calif. 94720–7360 2: Agency for Healthcare Research and Quality Postdoctoral Scholar, School of Public Health, University of California, Berkeley 3: Distinguished Professor, Health Economics & Public Policy 4: Director, Nicholas C. Penis Center on Health Care Markets and Consumer Welfare, School of Public Health, University of California, Berkeley; Source Info: Jan2007, Vol. 138 Issue 1, p94; Subject Term: DENTAL hygienists; Subject Term: DENTAL assistants; Subject Term: DENTISTS; Subject Term: SUPPLY & demand; Subject Term: UNITED States; Author-Supplied Keyword: dental assistants; Author-Supplied Keyword: Dental hygienists; Author-Supplied Keyword: labor shortage; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23737105&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Organ Donation: The Gift of Life
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2007/01//
VL - 107
IS - 1
M3 - Editorial
SP - 15
EP - 15
SN - 00028223
N1 - Accession Number: 23553546; Moritsugu, Kenneth P. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Jan2007, Vol. 107 Issue 1, p15; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2006.11.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23553546&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106282084
T1 - From the Surgeon General. Organ donation: the gift of life.
AU - Moritsugu KP
Y1 - 2007/01//
N1 - Accession Number: 106282084. Language: English. Entry Date: 20070511. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Organ Procurement -- Methods
KW - Organ Transplantation -- Psychosocial Factors
KW - Quality of Life
SP - 15
EP - 15
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 107
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Acting US Surgeon General, US Department of Health and Human Services
U2 - PMID: 17197259.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106282084&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY -
AU - McCormick, Kathleen A.1, kathleen.a.mccormick@saic.com
AU - Delaney, Connie J.2
AU - Brennan, Patricia Flatley3,4
AU - Effken, Judith A.5
AU - Kendrick, Kathie6
AU - Murphy, Judy7
AU - Skiba, Diane J.8
AU - Warren, Judith J.9
AU - Weaver, Charlotte A.10
AU - Weiner, Betsy11
AU - Westra, Bonnie L.12
T1 - Guideposts to the Future--An Agenda for Nursing Informatics.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2007/01//Jan/Feb2007
Y1 - 2007/01//Jan/Feb2007
VL - 14
IS - 1
CP - 1
M3 - Article
SP - 19
EP - 24
SN - 10675027
AB - As new directions and priorities emerge in health care, nursing informatics leaders must prepare to guide the profession appropriately. To use an analogy, where a road bends or changes directions, guideposts indicate bow drivers can stay on course. The AMIA Nursing Informatics Working Group (NIWG) produced this white paper as the product of a meeting convened: 1) to describe anticipated nationwide changes in demographics, health care quality, and health care informatics; 2) to assess the potential impact of genomic medicine and of new threats to society; 3) to align AMIA NIWG resources with emerging priorities; and 4) to identify guideposts in the form of an agenda to keep the NIWG on course in light of new opportunities. The anticipated societal changes provide opportunities for nursing informatics. Resources described below within the Department of Health and Human Services (HHS) and the National Committee for Health and Vital Statistics (NCVHS) can help to align AMIA NIWG with emerging priorities. The guideposts consist of priority, areas for action in informatics, nursing education, and research. Nursing informatics professionals will collaborate as full participants in local, national, and international efforts related to the guideposts in order to make significant contributions that empower patients and providers for safer health care. [ABSTRACT FROM AUTHOR]
KW - Nursing informatics
KW - Medical informatics
KW - Medical care -- Quality control
KW - Medical care -- United States
KW - United States
N1 - Accession Number: 23648161; Authors: McCormick, Kathleen A. 1 Email Address: kathleen.a.mccormick@saic.com; Delaney, Connie J. 2; Brennan, Patricia Flatley 3,4; Effken, Judith A. 5; Kendrick, Kathie 6; Murphy, Judy 7; Skiba, Diane J. 8; Warren, Judith J. 9; Weaver, Charlotte A. 10; Weiner, Betsy 11; Westra, Bonnie L. 12; Affiliations: 1: SAIC Health Solutions, Falls Church, VA; 2: School of Nursing, University of Minnesota, Minneapolis, MN; 3: College of Engineering, University of Wisconsin-Madison, Madison, WI; 4: School of Nursing, University of Wisconsin-Madison, Madison, WI; 5: College of Nursing, University of Arizona, Tucson, AZ; 6: Office of Performance Accountability, Resources and Technology, Agency for Healthcare Research and Quality, Rockville, MD; 7: Aurora Health Care, Milwaukee, WI; 8: School of Nursing, University of Colorado, Denver, CO; 9: School of Nursing, University of Kansas, Kansas City, KS; 10: Cerner Corporation, Kansas City, MO; 11: Vanderbilt University, Nashville, TN; 12: University of Minnesota, Minneapolis, MN; Subject: Nursing informatics; Subject: Medical informatics; Subject: Medical care -- Quality control; Subject: Medical care -- United States; Subject: United States; Number of Pages: 6p; Illustrations: 1 Diagram; Record Type: Article
L3 - 10.1197/jamia.M1996
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=23648161&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Kim, Se Na
AU - Jeong, Hye Sung
AU - Park, Sue Nie
AU - Kim, Hong-Jin
T1 - Purification and immunogenicity study of human papillomavirus type 16 L1 protein in Saccharomyces cerevisiae
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2007/01//
VL - 139
IS - 1
M3 - Article
SP - 24
EP - 30
SN - 01660934
AB - Abstract: Human papillomavirus 16 virus-like particle (HPV16 VLP) vaccines expressed in Saccharomyces cerevisiae are under Phase III trial and are expected to be on the market in the near future. We have established a convenient and economical system for the prophylactic study of vaccines derived from HPV16 VLPs, and neutralization tests to standardize HPV serological methodology as a measure of validation. To purify HPV16 VLPs, yeast cells expressing HPV16 L1 protein were cultured and purified on a small scale by ultracentrifugation and size-exclusion and cation-exchange chromatography using open columns. The highly purified HPV16 L1 protein was identified by SDS-PAGE and Western blotting, and electron microscopic analysis confirmed that they self-assembled into VLPs. To test the efficacy of the purified VLPs as a vaccine and their ability to induce humoral immunity, we performed ELISA assays and observed a significant increase in the titer of anti-HPV16 VLPs antibodies in the sera of immunized mice. High anti-HPV16 neutralizing titers were found in the sera of vaccinated mice, as measured by a SEAP-based pseudovirus neutralization assay. These results would be useful in the evaluation of the immunogenicity of HPV vaccine candidates, and provide an international reference standard for HPV serological methods. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - PAPILLOMAVIRUSES
KW - PREVENTIVE medicine
KW - MEDICAL care
KW - Human papillomavirus (HPV)
KW - Neutralization assay
KW - Virus-like particle (VLP)
N1 - Accession Number: 23349579; Kim, Se Na 1 Jeong, Hye Sung 1 Park, Sue Nie 2 Kim, Hong-Jin 1; Email Address: hongjink@cau.ac.kr; Affiliation: 1: College of Pharmacy, Chung Ang University, 221 Huksuk-Dong, Dongjak-Ku, Seoul 156-756, Republic of Korea 2: Department of Biologics Evaluation, Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-Gu, Seoul 122-704, Republic of Korea; Source Info: Jan2007, Vol. 139 Issue 1, p24; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: PAPILLOMAVIRUSES; Subject Term: PREVENTIVE medicine; Subject Term: MEDICAL care; Author-Supplied Keyword: Human papillomavirus (HPV); Author-Supplied Keyword: Neutralization assay; Author-Supplied Keyword: Virus-like particle (VLP); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.09.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23349579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Crim, Robert L.
AU - Audet, Susette A.
AU - Feldman, Steven A.
AU - Mostowski, Howard S.
AU - Beeler, Judy A.
T1 - Identification of Linear Heparin-Binding Peptides Derived from Human Respiratory Syncytial Virus Fusion Glycoprotein That Inhibit Infectivity.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2007/01//
VL - 81
IS - 1
M3 - Article
SP - 6
EP - 6
SN - 0022538X
AB - It has been shown previously that the fusion glycoprotein of human respiratory syncytial virus (RSV-F) interacts with cellular heparan sulfate. Synthetic overlapping peptides derived from the F-protein sequence of RSV subtype A (strain A2) were tested for their ability to bind heparin using heparin-agarose affinity chromatography (HAAC). This evaluation identified 15 peptides representing eight linear heparin-binding domains (HBDs) located within F1 and F2 and spanning the protease cleavage activation site. All peptides bound to Vero and A549 cells, and binding was inhibited by soluble heparins and diminished by either enzymatic treatment to remove cell surface glycosaminoglycans or by treatment with sodium chlorate to decrease cellular sulfation. RSV-F HBD peptides were less likely to bind to glycosaminoglycan-deficient CHO-745 cells than parental CHO-K1 cells that express these molecules. Three RSV-F HBD peptides (F16, F26, and F55) inhibited virus infectivity; two of these peptides (F16 and F55) inhibited binding of virus to Vero cells, while the third (F26) did not. These studies provided evidence that two of the linear HBDs mapped by peptides F16 and F55 may mediate one of the first steps in the attachment of virus to cells while the third, F26, inhibited infectivity at a postattachment step, suggesting that interactions with cell surface glycosaminoglycans may play a role in infectivity of some RSV strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - RESPIRATORY infections
KW - HEPARIN
KW - CHROMATOGRAPHIC analysis
KW - GLYCOSAMINOGLYCANS
N1 - Accession Number: 23746460; Crim, Robert L. 1 Audet, Susette A. 1 Feldman, Steven A. 1 Mostowski, Howard S. 2 Beeler, Judy A. 1; Email Address: judy.beeler@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 2: Division of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Jan2007, Vol. 81 Issue 1, p6; Subject Term: GLYCOPROTEINS; Subject Term: RESPIRATORY infections; Subject Term: HEPARIN; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: GLYCOSAMINOGLYCANS; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.01226-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23746460&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeon, Dae Hoon
AU - Park, Gun Young
AU - Kwak, In Shin
AU - Lee, Kwang Ho
AU - Park, Hyun Jin
T1 - Antioxidants and their migration into food simulants on irradiated LLDPE film
JO - LWT - Food Science & Technology
JF - LWT - Food Science & Technology
Y1 - 2007/01//
VL - 40
IS - 1
M3 - Article
SP - 151
EP - 156
SN - 00236438
AB - Abstract: Effects of γ-irradiation on residual and migration levels of antioxidants, tris-(2,4-di-tert-butylphenyl) phosphite (Irgafos 168) and octadecyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate (Irganox 1076), and their radiolysis products were investigated in the linear low density polyethylene (LLDPE) packaging samples treated at doses from 0 to 200kGy. The content of Irgafos 168 was not detected in 5kGy treated samples and the content of Irganox 1076 decreased by 34.9% from the initial level in 10kGy treated samples. The radiolysis products, 2,4-di-tert-butylphenol (2,4-DTBP), 1,3-di-tert-butylbenzene (1,3-DTBB), and toluene were identified and their concentrations gradually increased as the irradiation dose increased. Migration of Irgafos 168 from the LLDPE pouch into food simulants, distilled water, acetic acid (4ml/100ml distilled water) or ethanol (20ml/100ml distilled water), was not detected at dose levels up to 200kGy while that of the Irganox 1076 was detected in a decreasing mode with increasing dose. [Copyright &y& Elsevier]
AB - Copyright of LWT - Food Science & Technology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIOXIDANTS
KW - ACETIC acid
KW - FATTY acids
KW - FOOD industry
KW - γ-irradiation
KW - Antioxidants
KW - LLDPE
KW - Migration level
N1 - Accession Number: 21776007; Jeon, Dae Hoon 1,2 Park, Gun Young 1 Kwak, In Shin 2 Lee, Kwang Ho 2 Park, Hyun Jin 1,3; Email Address: hjpark@korea.ac.kr; Affiliation: 1: Graduate School of Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Korea 2: Food Packaging Division, Korea Food and Drug Administration (KFDA), 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122-704, Korea 3: Department of Packaging Science, Clemson University, Clemson, SC 29634-0370, USA; Source Info: Jan2007, Vol. 40 Issue 1, p151; Subject Term: ANTIOXIDANTS; Subject Term: ACETIC acid; Subject Term: FATTY acids; Subject Term: FOOD industry; Author-Supplied Keyword: γ-irradiation; Author-Supplied Keyword: Antioxidants; Author-Supplied Keyword: LLDPE; Author-Supplied Keyword: Migration level; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.lwt.2005.05.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=21776007&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parent, Michelle A.
AU - Goenka, Radhika
AU - Murphy, Erin
AU - LeVier, Kristen
AU - Carreiro, Nuno
AU - Golding, Basil
AU - Ferguson, Gail
AU - Roop, R. Martin
AU - Walker, Graham C.
AU - Baldwin, Cynthia L.
T1 - Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2007/01//
VL - 9
IS - 1
M3 - Article
SP - 55
EP - 62
SN - 12864579
AB - Abstract: The inner-membrane protein BacA affects Brucella LPS structure. A bacA deletion mutant of Brucella abortus, known as KL7 (bacAmut-KL7), is attenuated in BALB/c mice and protects against challenge. Thus, bacA mutation was a candidate for incorporation into live attenuated vaccines. We assessed bacAmut-KL7 in 2 additional mouse strains: the more resistant C57BL/6 that produces interferon-γ throughout the infection and the highly susceptible interferon-γ-deficient C57BL/6 in which brucellae exhibit continual exponential growth. While it was hypothesized that bacAmut-KL7 would exhibit even greater attenuation relative to its parent strain B. abortus 2308 in C57BL/6 mice than it did in BALB/c mice, this was not the case. Moreover, it was more pathogenic in C57BL/6 interferon-γ-deficient mice than 2308 causing abscesses and wasting even though the splenic loads of bacAmut-KL7 were significantly lower. These 2 observations were correlated, respectively, with an ability of IFNγ-activated macrophages to equivalently control strains 2308 and bacAmut-KL7 and the ability of bacAmut-KL7 organism and its LPS to induce greater amounts of pro-inflammatory cytokines than 2308. We conclude that attenuation properties of bacA mutation are dependent upon the nature of the host but more importantly that bacterial gene deletion can result in increased host pathology without an increase in bacterial load, crucial considerations for vaccine design. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Brucella abortus
KW - Cytokines
KW - Brucellosis
KW - Interleukins
KW - bacA
KW - Brucella
KW - colony forming units ( CFU )
KW - interferon-γ ( IFNγ )
KW - interleukin ( IL )
KW - Intracellular bacteria
KW - lipopolysaccharide ( LPS )
KW - phosphate-buffered saline ( PBS )
KW - toll-like receptor ( TLR )
KW - tumor necrosis factor-α ( TNFα )
N1 - Accession Number: 23809520; Parent, Michelle A. 1; Goenka, Radhika 1; Murphy, Erin 1; LeVier, Kristen 2; Carreiro, Nuno 1; Golding, Basil 3; Ferguson, Gail 2; Roop, R. Martin 4; Walker, Graham C. 2; Baldwin, Cynthia L. 1; Email Address: cbaldwin@vasci.umass.edu; Affiliations: 1: Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA; 2: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; 3: Division of Hematology, Food and Drug Administration, Bethesda, MD 20892, USA; 4: Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27858, USA; Issue Info: Jan2007, Vol. 9 Issue 1, p55; Subject Term: Brucella abortus; Subject Term: Cytokines; Subject Term: Brucellosis; Subject Term: Interleukins; Author-Supplied Keyword: bacA; Author-Supplied Keyword: Brucella; Author-Supplied Keyword: colony forming units ( CFU ); Author-Supplied Keyword: interferon-γ ( IFNγ ); Author-Supplied Keyword: interleukin ( IL ); Author-Supplied Keyword: Intracellular bacteria; Author-Supplied Keyword: lipopolysaccharide ( LPS ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: toll-like receptor ( TLR ); Author-Supplied Keyword: tumor necrosis factor-α ( TNFα ); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.micinf.2006.10.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23809520&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Karnaukhova, Elena
AU - Ophir, Yakir
AU - Trinh, Loc
AU - Dalal, Nimish
AU - Punt, Peter J.
AU - Golding, Basil
AU - Shiloach, Joseph
T1 - Expression of human αI-proteinase inhibitor in Aspergillus niger.
JO - Microbial Cell Factories
JF - Microbial Cell Factories
Y1 - 2007/01//
VL - 6
M3 - Article
SP - 34
EP - 43
SN - 14752859
AB - Background: Human α1-proteinase inhibitor (α1-PI), also known as antitrypsin, is the most abundant serine protease inhibitor (serpin) in plasma. Its deficiency is associated with development of progressive, ultimately fatal emphysema. Currently in the United States, α1-PI is available for replacement therapy as an FDA licensed plasma-derived (pd) product. However, the plasma source itself is limited; moreover, even with efficient viral inactivation steps used in manufacture of plasma products, the risk of contamination from emerging viruses may still exist. Therefore, recombinant α1-PI (r-α1-PI) could provide an attractive alternative. Although r-α1-PI has been produced in several hosts, protein stability in vitro and rapid clearance from the circulation have been major issues, primarily due to absent or altered glycosylation. Results: We have explored the possibility of expressing the gene for human α1-PI in the filamentous fungus Aspergillus niger (A. niger), a system reported to be capable of providing more "mammalian-like" glycosylation patterns to secretable proteins than commonly used yeast hosts. Our expression strategy was based on fusion of α1-PI with a strongly expressed, secreted leader protein (glucoamylase G2), separated by dibasic processing site (N-V-I-S-K-R) that provides in vivo cleavage. SDS-PAGE, Western blot, ELISA, and α1-PI activity assays enabled us to select the transformant(s) secreting a biologically active glycosylated r-α1-PI with yields of up to 12 mg/L. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis further confirmed that molecular mass of the r-α1-PI was similar to that of the pd-α1-PI. In vitro stability of the r-α1-PI from A. niger was tested in comparison with pd-α1-PI reference and non-glycosylated human r-α1-PI from E. coli. Conclusion: We examined the suitability of the filamentous fungus A. niger for the expression of the human gene for α1-PI, a medium size glycoprotein of high therapeutic value. The heterologous expression of the human gene for α1-PI in A. niger was successfully achieved to produce the secreted mature human r-α1-PI in A. niger as a biologically active glycosylated protein with improved stability and with yields of up to 12 mg/L in shake-flask growth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbial Cell Factories is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINASES
KW - TRYPSIN inhibitors
KW - PROTEASE inhibitors
KW - PLASMA products
KW - VIRUSES
KW - PROTEINS
KW - GLYCOSYLATION
N1 - Accession Number: 34984623; Karnaukhova, Elena 1; Email Address: elena.karnaukhova@fda.hhs.gov Ophir, Yakir 1; Email Address: ophiryakir@yahoo.com Trinh, Loc 2; Email Address: loct@intra.niddk.nih.gov Dalal, Nimish 2; Email Address: nimish.dalal@bms.com Punt, Peter J. 3; Email Address: peter.punt@tno.nl Golding, Basil 1; Email Address: basil.golding@fda.hhs.gov Shiloach, Joseph 2; Email Address: ljs@helix.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda,Maryland, 20892 USA 2: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, 20892 USA 3: Department of Microbiology, TNO Quality of Life, 3704 HE Zeist, the Netherlands; Source Info: 2007, Vol. 6, p34; Subject Term: PROTEINASES; Subject Term: TRYPSIN inhibitors; Subject Term: PROTEASE inhibitors; Subject Term: PLASMA products; Subject Term: VIRUSES; Subject Term: PROTEINS; Subject Term: GLYCOSYLATION; Number of Pages: 10p; Document Type: Article
L3 - 10.1186/1475-2859-6-34
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34984623&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gibson, Brent Randall
AU - Fox-Samson, Connie L.
AU - Rowe, John R.
T1 - Civilian Medical Qualification Determinations.
JO - Military Medicine
JF - Military Medicine
Y1 - 2007/01//
VL - 172
IS - 1
M3 - Article
SP - 58
EP - 62
PB - AMSUS
SN - 00264075
AB - Much like their counterparts in private industry, federal medical officers, particularly preventive and occupational medicine physicians, must ensure a workforce fit to perform their duties. Meeting this objective often requires balancing competing interests between employers and employees. The medical examination is the method for protecting the government's interests in identifying federal civilian applicants and workers who are medically unqualified to perform their duties while also preventing discrimination against qualified individuals with disabilities. Scant published guidance on performing authorized medical examinations and analyzing the resultant information is available for federal medical officers. This is needed to foster an equitable, compliant decision for both federal employers and employees. Using the Department of Defense as an example, this article provides a legal road map for the practitioner by defining medical standards and physical requirements, discussing medical examinations, and examining disability determinations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL personnel
KW - EMPLOYERS
KW - EMPLOYEES
KW - MEDICAL screening
KW - PEOPLE with disabilities
KW - UNITED States
KW - UNITED States. Dept. of Defense
N1 - Accession Number: 23694576; Gibson, Brent Randall 1 Fox-Samson, Connie L. 2 Rowe, John R. 3; Affiliation: 1: Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Room 1040A, Bethesda, MD 20814 2: U.S. Army Center for Health Promotion and Preventive Medicine, Directorate of Occupational and Environmental Medicine, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010 3: U.S. Army, Occupational Medicine Staff Officer, Office of The Surgeon General, 5109 Leesburg Pike, Falls Church, VA 22041; Source Info: Jan2007, Vol. 172 Issue 1, p58; Subject Term: MEDICAL personnel; Subject Term: EMPLOYERS; Subject Term: EMPLOYEES; Subject Term: MEDICAL screening; Subject Term: PEOPLE with disabilities; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Defense; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Niebuhr, David W.
AU - Yuanzhang Li
AU - Powers, Timothy E.
AU - Krauss, Margot R.
AU - Chandler, David
AU - Heifer, Thomas
T1 - Attrition of U.S. Military Enlistees with Waivers for Hearing Deficiency, 1995-2004.
JO - Military Medicine
JF - Military Medicine
Y1 - 2007/01//
VL - 172
IS - 1
M3 - Article
SP - 63
EP - 69
PB - AMSUS
SN - 00264075
AB - Background: Hearing deficiency is the condition for which accession medical waivers are most commonly granted. The retention of individuals entering service with a waiver for hearing deficiency has not been previously studied. Methods: Military retention among new enlistees with a medical waiver for hearing deficiency was compared with that among a matched comparison group of fully qualified enlistees. Comparisons according to branch of service over the first 3 years of service were performed with the Kaplan-Meier product-limit method and proportional-hazards model. Results: Army subjects had significantly lower retention rates than did their fully qualified counterparts. In the adjusted model, Army and Navy enlistees with a waiver for hearing deficiency had a significantly lower likelihood of retention than did their matched counterparts. Discussion: The increased likelihood of medical attrition in enlistees with a waiver for hearing loss provides no evidence to make the hearing accession standard more lenient and validates a selective hearing loss waiver policy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEAFNESS
KW - WAIVER
KW - MILITARY personnel
KW - ARMIES
KW - NAVIES
KW - ATTRITION (Military science)
N1 - Accession Number: 23694577; Niebuhr, David W. 1 Yuanzhang Li 1 Powers, Timothy E. 1 Krauss, Margot R. Chandler, David 2 Heifer, Thomas 3; Affiliation: 1: Waiter Reed Army Institute of Research, Division of Preventive Medicine, Silver Spring, MD 20910 2: Department of Defense Executive Agencies, Office of the Surgeon General, Falls Church, VA 22041 3: U.S. Army Center for Health Promotion and Preventive Medicine, Hearing Conservation Program, Aberdeen Proving Ground, MD 21010-5403; Source Info: Jan2007, Vol. 172 Issue 1, p63; Subject Term: DEAFNESS; Subject Term: WAIVER; Subject Term: MILITARY personnel; Subject Term: ARMIES; Subject Term: NAVIES; Subject Term: ATTRITION (Military science); Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Qing Lin
AU - Dingge Li
AU - Xijin Xu
AU - Xiaoju Zou
AU - Li Fang
T1 - Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.
JO - Molecular Pain
JF - Molecular Pain
Y1 - 2007/01//
VL - 3
M3 - Article
SP - 1
EP - 14
SN - 17448069
AB - Background: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in inflammation. However, no direct evidence demonstrates that the release of inflammatory substances is due to the triggering of DRRs and how activation of TRPV1 receptors initiates neurogenic inflammation via triggering DRRs. Results: Here we used pharmacological manipulations to analyze the roles of TRPV1 and neuropeptidergic receptors in the DRR-mediated neurogenic inflammation induced by intradermal injection of capsaicin. The degree of cutaneous inflammation in the hindpaw that followed capsaicin injection was assessed by measurements of local blood flow (vasodilation) and paw-thickness (edema) of the foot skin in anesthetized rats. Local injection of capsaicin, calcitonin gene-related peptide (CGRP) or substance P (SP) resulted in cutaneous vasodilation and edema. Removal of DRRs by either spinal dorsal rhizotomy or intrathecal administration of the GABAA receptor antagonist, bicuculline, reduced dramatically the capsaicin-induced vasodilation and edema. In contrast, CGRP- or SP-induced inflammation was not significantly affected after DRR removal. Dose-response analysis of the antagonistic effect of the TRPV1 receptor antagonist, capsazepine administered peripherally, shows that the capsaicin-evoked inflammation was inhibited in a dose-dependent manner, and nearly completely abolished by capsazepine at doses between 30-150 μg. In contrast, pretreatment of the periphery with different doses of CGRP8-37 (a CGRP receptor antagonist) or spantide I (a neurokinin 1 receptor antagonist) only reduced the inflammation. If both CGRP and NK1 receptors were blocked by co-administration of CGRP8-37 and spantide I, a stronger reduction in the capsaicin-initiated inflammation was produced. Conclusion: Our data suggest that 1) the generation of DRRs is critical for driving the release of neuropeptides antidromically from primary afferent nociceptors; 2) activation of TRPV1 receptors in primary afferent nociceptors following intradermal capsaicin injection initiates this process; 3) the released CGRP and SP participate in neurogenic inflammation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Pain is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRP channels
KW - CAPSAICIN
KW - NEUROPEPTIDES
KW - NOCICEPTORS
KW - PEPTIDES
KW - GENES
N1 - Accession Number: 28834153; Qing Lin 1; Email Address: qilin@utmb.edu Dingge Li 1; Email Address: dili@utmb.edu Xijin Xu 1; Email Address: xijxu@utmb.edu Xiaoju Zou 1,2; Email Address: xiaju.zou@fda.hhs.gov Li Fang 3; Email Address: lfang@utmb.edu; Affiliation: 1: Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555-1069, USA 2: Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, USA 3: Division of Neurosurgery, Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555-1043, USA; Source Info: 2007, Vol. 3, p1; Subject Term: TRP channels; Subject Term: CAPSAICIN; Subject Term: NEUROPEPTIDES; Subject Term: NOCICEPTORS; Subject Term: PEPTIDES; Subject Term: GENES; Number of Pages: 14p; Document Type: Article
L3 - 10.1186/1744-8069-3-30
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28834153&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hilde E. van Gijssel
AU - Tarek A. Leil
AU - Wendy C. Weinberg
AU - Rao L. Divi
AU - Ofelia A. Olivero
AU - Miriam C. Poirier
T1 - Cisplatin–DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin.
JO - Mutagenesis
JF - Mutagenesis
Y1 - 2007/01//
VL - 22
IS - 1
M3 - Article
SP - 49
EP - 54
SN - 02678357
AB - In response to DNA damage, cell cycle arrest, apoptosis, and DNA repair are mediated by a TP53 pathway that induces p21WAF1/Cip1. The chemotherapeutic drug cis-diamminedichloroplatinum-II (cisplatin) damages cellular DNA by forming cis-diammineplatinum-N7-d[GpG] and cis-diammine-platinum-N7-d[ApG] adducts. To investigate the role of p21, skin keratinocytes from p21WAF1/Cip1 wild-type (+/+), heterozygous (+/?), and null (?/?) mice, cultured in calcium levels designed to maintain a proliferating state, were exposed to 5 ?M cisplatin continuously for 0, 8, 24, 48 and 72 h. At all time points the (+/?) cells had the fewest Pt-DNA adducts, and at 24 h mean Pt-DNA adduct levels were 541, 153 and 779 fmol adduct/?g DNA for p21WAF1/Cip1 (+/+), (+/?) and (?/?) cells, respectively [P < 0.05 for (+/+) versus (+/?) and (?/?) versus (+/?)]. In order to understand underlying events, we examined p21WAF1/Cip1 messenger RNA (mRNA), cell cycle arrest, and apoptosis in these cells. At 48 h of cisplatin exposure p21WAF1/Cip1 mRNA expression was 2-fold higher in the (+/+) cells, compared to the (+/?) cells. At 24 h, the % of cells in S-phase in cisplatin-exposed cultures, compared to unexposed cultures, was decreased by 51, 40 and 11% in p21WAF1/Cip1 (+/+), (+/?) and (?/?) cells, respectively (P = 0.04, ANOVA). At 24, 48 and 72 h the % of cisplatin-exposed (+/+) cells in apoptosis was 9.4–10.5%, while the cisplatin-exposed (+/?) and (?/?) cells had 1.2–3.7% of cells in apoptosis. The data support the interpretation that DNA replication arrest and apoptosis do not completely explain the low levels of Pt-DNA adducts in the (+/?) cells, and suggest that p21WAF1/Cip1 controls activity resulting in either low Pt-DNA adduct formation or enhanced Pt-DNA adduct removal. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mutagenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CISPLATIN
KW - DNA damage
KW - KERATINOCYTES
KW - DNA repair
N1 - Accession Number: 23650855; Hilde E. van Gijssel 1 Tarek A. Leil 1 Wendy C. Weinberg 2 Rao L. Divi 1 Ofelia A. Olivero 1 Miriam C. Poirier 1; Affiliation: 1: Laboratory of Cellular Carcinogenesis and Tumor Promotion, CCR, National Cancer Institute, Building 37 Room 4032, NIH Bethesda, MD 20892-4255 2: Laboratory of ImmunoBiology, Office of Biotechnology Products, CDER, US Food and Drug Administration Bethesda, MD 20892; Source Info: Jan2007, Vol. 22 Issue 1, p49; Subject Term: CISPLATIN; Subject Term: DNA damage; Subject Term: KERATINOCYTES; Subject Term: DNA repair; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Rudenko, Larisa
AU - Matheson, John C.
AU - Sundlof, Stephen F.
T1 - Animal cloning and the FDA—the risk assessment paradigm under public scrutiny.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2007/01//
VL - 25
IS - 1
M3 - Editorial
SP - 39
EP - 43
SN - 10870156
AB - The article discusses the preliminary risk assessment on animal cloning undertaken by the United States Food and Drug Administration. According to the FDA study, there are no risks either to animal health or to food consumption of food products derived from animals produced by somatic cell nuclear transfer. Emphasis is also made that the voluntary moratorium will not be lifted until the completion of the entire risk assessment.
KW - Risk assessment
KW - Food -- Safety measures
KW - Cloning -- Government policy
KW - Animal genetics
KW - Center for Veterinary Medicine (U.S.)
N1 - Accession Number: 23625873; Rudenko, Larisa 1; Email Address: larisa.rudenko@fda.hhs.gov; Matheson, John C. 1; Sundlof, Stephen F. 1; Affiliations: 1: Center for Veterinary Medicine, US Food and Drug Administration, Department of Health and Human Services, 7500 Standish Place, Rockville, Maryland 20855, USA; Issue Info: Jan2007, Vol. 25 Issue 1, p39; Thesaurus Term: Risk assessment; Thesaurus Term: Food -- Safety measures; Subject Term: Cloning -- Government policy; Subject Term: Animal genetics ; Company/Entity: Center for Veterinary Medicine (U.S.); Number of Pages: 5p; Illustrations: 1 Color Photograph; Document Type: Editorial
L3 - 10.1038/nbt0107-39
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moon, Andrea F.
AU - Garcia-Diaz, Miguel
AU - Bebenek, Katarzyna
AU - Davis, Bryan J.
AU - Zhong, Xuejun
AU - Ramsden, Dale A.
AU - Kunkel, Thomas A.
AU - Pedersen, Lars C.
T1 - Structural insight into the substrate specificity of DNA Polymerase μ.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2007/01//
VL - 14
IS - 1
M3 - Article
SP - 45
EP - 53
PB - Nature Publishing Group
SN - 15459993
AB - DNA polymerase μ (Pol μ) is a family X enzyme with unique substrate specificity that contributes to its specialized role in nonhomologous DNA end joining (NHEJ). To investigate Pol μ's unusual substrate specificity, we describe the 2.4 Å crystal structure of the polymerase domain of murine Pol μ bound to gapped DNA with a correct dNTP at the active site. This structure reveals substrate interactions with side chains in Pol μ that differ from other family X members. For example, a single amino acid substitution, H329A, has little effect on template-dependent synthesis by Pol μ from a paired primer terminus, but it reduces both template-independent and template-dependent synthesis during NHEJ of intermediates whose 3′ ends lack complementary template strand nucleotides. These results provide insight into the substrate specificity and differing functions of four closely related mammalian family X DNA polymerases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA polymerases
KW - RESEARCH
KW - NUCLEOSIDES
KW - NUCLEOTIDES
KW - AMINO acids
KW - BINDING sites (Biochemistry)
N1 - Accession Number: 23580345; Moon, Andrea F. 1 Garcia-Diaz, Miguel 1,2 Bebenek, Katarzyna 1,2 Davis, Bryan J. 3,4 Zhong, Xuejun 1,2 Ramsden, Dale A. 3,4 Kunkel, Thomas A. 1,2; Email Address: kunkel@niehs.nih.gov Pedersen, Lars C. 1; Affiliation: 1: Laboratory of Structural Biology, National Institute of Environmental Health Sciences (National Institutes of Health, US Department of Health and Human Services), 111 T.W. Alexander Drive, MD F3-09, Research Triangle Park, North Carolina 27709, USA 2: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (National Institutes of Health, US Department of Health and Human Services), 111 T.W. Alexander Drive, MD F3-09, Research Triangle Park, North Carolina 27709, USA 3: (National Institutes of Health, US Department of Health and Human Services), 111 T.W. Alexander Drive, MD F3-09, Research Triangle Park, North Carolina 27709, USA Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (National Institutes of Health, US Department of Health and Human Services), 111 T.W. Alexander Drive, MD F3-09, Research Triangle Park, North Carolina 27709, USA Department of Biochemistry and Biophysics, 32-0444 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA 4: Curriculum in Genetics and Molecular Biology, 32-0444 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; Source Info: Jan2007, Vol. 14 Issue 1, p45; Subject Term: DNA polymerases; Subject Term: RESEARCH; Subject Term: NUCLEOSIDES; Subject Term: NUCLEOTIDES; Subject Term: AMINO acids; Subject Term: BINDING sites (Biochemistry); Number of Pages: 9p; Illustrations: 6 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/nsmb1180
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23580345&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kainz, Wolfgang
T1 - Response to Shellock et al. “Vagus Nerve Stimulation Therapy System: In Vitro Evaluation of Magnetic Resonance Imaging-Related Heating and Function at 1.5 and 3 Tesla”.
JO - Neuromodulation
JF - Neuromodulation
Y1 - 2007/01//
VL - 10
IS - 1
M3 - Letter
SP - 76
EP - 77
PB - Wiley-Blackwell
SN - 10947159
AB - A letter to the editor is presented in response to the article "Vagus Nerve Stimulation Therapy System: In Vitro Evaluation of Magnetic Resonance Imaging-Related Heating and Function at 1.5 and 3 Tesla," by Shellock and others in the July 2006 issue.
KW - LETTERS to the editor
KW - NEURAL stimulation
N1 - Accession Number: 23634175; Kainz, Wolfgang 1; Affiliation: 1: Division of Physics, HFZ-130 Office of Science and Engineering Laboratories, Center for Devices and Radiological Health Food and Drug Administration, U.S. Department of Health and Human Services Rockville, MD, USA; Source Info: Jan2007, Vol. 10 Issue 1, p76; Subject Term: LETTERS to the editor; Subject Term: NEURAL stimulation; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1525-1403.2007.00090.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23634175&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-01103-004
AN - 2008-01103-004
AU - Virmani, Ashraf
AU - Binienda, Zbigniew K.
AU - Ali, Syed F.
AU - Gaetani, Franco
ED - Slikker, William Jr.
ED - Andrews, Russell J.
ED - Trembly, Bruce
ED - Slikker, William Jr., (Ed)
ED - Andrews, Russell J., (Ed)
ED - Trembly, Bruce, (Ed)
T1 - Metabolic syndrome in drug abuse.
T2 - Neuroprotective agents: Eighth International Neuroprotection Society meeting.
T3 - Annals of the New York Academy of Sciences; Vol 1122; ISSN: 0077-8923 (Print)
Y1 - 2007///
VL - 1122
SP - 50
EP - 68
CY - Malden; New York, NY, US
PB - Blackwell Publishing
PB - New York Academy of Sciences
SN - 0077-8923
SN - 1-57331-685-7
SN - 978-1-57331-685-9
AD - Virmani, Ashraf, Sigma tau-HealthScience, Via Treviso 4, Pomezia, Italy, 00040
N1 - Accession Number: 2008-01103-004. Partial author list: First Author & Affiliation: Virmani, Ashraf; Sigma tau-HealthScience, Pomezia, Italy. Release Date: 20080407. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-685-7, Paperback; 978-1-57331-685-9, Paperback. Language: English. Conference Information: International Conference on Neuroprotective Agents, Eighth, Sep, 2006, Mackinac Island, MI, US. Conference Note: This report was presented at the aforementioned conference. Major Descriptor: Drug Abuse; Nutrition; Nutritional Deficiencies; Risk Factors; Toxicity. Minor Descriptor: Cognitive Impairment. Classification: Substance Abuse & Addiction (3233); Physiological Psychology & Neuroscience (2500). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 19.
AB - Drug abuse is associated with significant health risk. Whether drug abusers are at a higher risk of suffering the metabolic syndrome is not widely known. The metabolic syndrome is a cluster of metabolic abnormalities, including hyperinsulinemia, hypertension, dyslipidemia, and abdominal obesity, and is probably triggered by initial imbalances at the cellular level in various critical metabolic pathways. These initially small metabolic imbalances are believed to cascade with time and lead to larger problems. Some indications that drug abuse may increase the risk of the metabolic syndrome include the following: a) Drug-abusing patients have higher rates of diabetes complications. b) Substance abuse is a significant contributing factor for treatment noncompliance in diabetes. c) Nutrition education can enhance substance abuse treatment outcomes. Each type of drug/substance abuse has a unique profile of toxicity. For example, the amphetamines generally affect the cardiovascular and neurological systems, worsening the risk factors for the metabolic syndrome. Methamphetamine (meth) abusers suffer cognitive deficits and abnormal metabolic activity, which affect nutritional status. This condition is further worsened by a drastic reduction in oral health in meth abusers, resulting in improper chewing and, therefore, digestion. Nutritional deficiency in combination with drug abuse would increase the risk of developing the metabolic syndrome by increasing cell damage, augmenting excitotoxicity, reducing energy production, and lowering the antioxidant potential of the cells. Another potential risk factor in the development of the metabolic syndrome is genetic vulnerability, especially in combination with drug abuse and nutritional deficiencies. The strategies available to treat this problem include pharmacological agents as well as dietary antioxidants. Such measures may be useful in reducing drug abuse-related toxicity that may lead to the metabolic syndrome. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - metabolic syndrome
KW - drug abuse
KW - substance abuse
KW - toxicity
KW - nutrition
KW - nutritional deficiencies
KW - risk factors
KW - 2007
KW - Drug Abuse
KW - Nutrition
KW - Nutritional Deficiencies
KW - Risk Factors
KW - Toxicity
KW - Cognitive Impairment
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01103-004&site=ehost-live&scope=site
UR - ashraf.virmani@st-hs.it
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-01103-014
AN - 2008-01103-014
AU - Sharma, Hari Shanker
AU - Ali, Syed F.
AU - Dong, W.
AU - Tian, Z. Ryan
AU - Patnaik, R.
AU - Patnaik, S.
AU - Sharma, Aruna
AU - Boman, Arne
AU - Lek, Per
AU - Seifert, Elisabeth
AU - Lundstedt, And Torbjörn
ED - Slikker, William Jr.
ED - Andrews, Russell J.
ED - Trembly, Bruce
ED - Slikker, William Jr., (Ed)
ED - Andrews, Russell J., (Ed)
ED - Trembly, Bruce, (Ed)
T1 - Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord.
T2 - Neuroprotective agents: Eighth International Neuroprotection Society meeting.
T3 - Annals of the New York Academy of Sciences; Vol 1122; ISSN: 0077-8923 (Print)
Y1 - 2007///
VL - 1122
SP - 197
EP - 218
CY - Malden; New York, NY, US
PB - Blackwell Publishing
PB - New York Academy of Sciences
SN - 0077-8923
SN - 1-57331-685-7
SN - 978-1-57331-685-9
AD - Sharma, Hari Shanker, Frodingsgatan 12.28, SE-75421, Uppsala, Sweden
N1 - Accession Number: 2008-01103-014. Partial author list: First Author & Affiliation: Sharma, Hari Shanker; Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden. Release Date: 20080407. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-685-7, Paperback; 978-1-57331-685-9, Paperback. Language: English. Conference Information: International Conference on Neuroprotective Agents, Eighth, Sep, 2006, Mackinac Island, MI, US. Conference Note: This report was presented at the aforementioned conference. Major Descriptor: Central Nervous System; Drug Administration Methods; Protective Factors; Spinal Cord Injuries; Nanotechnology. Minor Descriptor: Animal Models; Medical Therapeutic Devices; Rats; Recovery (Disorders); Neuroprotection. Classification: Physiological Psychology & Neuroscience (2500); Medical Treatment of Physical Illness (3363). Population: Animal (20); Male (30). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 22.
AB - The possibility that drugs attached to innocuous nanowires enhance their delivery within the central nervous system (CNS) and thereby increase their therapeutic efficacy was examined in a rat model of spinal cord injury (SCI). Three compounds--AP173 (SCI-1), AP713 (SCI-2), and AP364 (SCI-5) (Acure Pharma, Uppsala, Sweden)--were tagged with TiO₂-based nanowires using standard procedure. Normal compounds were used for comparison. SCI was produced by making a longitudinal incision into the right dorsal horn of the T10-T11 segments under Equithesin anesthesia. The compounds, either alone or tagged with nanowires, were applied topically within 5 to lOmin after SCI. In these rats, behavioral outcome, blood-spinal cord barrier (BSCB) permeability, edema formation, and cell injury were examined at 5h after injury. Topical application of normal compounds in high quantity (10 μg in 20 μL) attenuated behavioral dysfunction (3 h after trauma), edema formation, and cell injury, as well as reducing BSCB permeability to Evans blue albumin and ¹³¹I. These beneficial effects are most pronounced with AP713 (SCI-2) treatment. Interestingly, when these compounds were administered in identical conditions after tagging with nanowires, their beneficial effects on functional recovery and spinal cord pathology were further enhanced. However, topical administration of nanowires alone did not influence trauma-induced spinal cord pathology or motor functions. Taken together, our results, probably for the first time, indicate that drug delivery and therapeutic efficacy are enhanced when the compounds are administered with nanowires. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drugs
KW - spinal cord injury
KW - nanowires
KW - central nervous system
KW - therapeutic efficacy
KW - rat model
KW - drug delivery
KW - neuroprotective efficacy
KW - functional recovery
KW - 2007
KW - Central Nervous System
KW - Drug Administration Methods
KW - Protective Factors
KW - Spinal Cord Injuries
KW - Nanotechnology
KW - Animal Models
KW - Medical Therapeutic Devices
KW - Rats
KW - Recovery (Disorders)
KW - Neuroprotection
KW - 2007
U1 - Sponsor: Air Force Office of Scientific Research, United Kingdom. Recipients: No recipient indicated
U1 - Sponsor: USAF, Air Force Material Command, US. Grant: FA8655-05-1-3065. Recipients: No recipient indicated
U1 - Sponsor: Acure Pharma, Sweden. Recipients: No recipient indicated
U1 - Sponsor: Astra-Zeneca, Sweden. Recipients: No recipient indicated
U1 - Sponsor: Alexander von Humboldt Foundation, Germany. Recipients: No recipient indicated
U1 - Sponsor: IPSEN Medical, France. Recipients: No recipient indicated
U1 - Sponsor: Ebewe Pharma, Austria. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01103-014&site=ehost-live&scope=site
UR - sharma@surgsci.uu.se
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2007-13965-004
AN - 2007-13965-004
AU - Chen, Tao
AU - Mei, Nan
AU - Heflich, Robert H.
ED - Valon, Charles L.
ED - Valon, Charles L., (Ed)
T1 - Progress in transgenic rodent mutation assays.
T2 - New developments in mutation research.
T3 - Nova Biomedical
Y1 - 2007///
SP - 71
EP - 96
CY - Hauppauge, NY, US
PB - Nova Science Publishers
SN - 1-59454-664-9
SN - 978-1-59454-664-8
AD - Chen, Tao, HFT-130, NCTR, 3900 NCTR Rd, Jefferson, AR, US, 72079
N1 - Accession Number: 2007-13965-004. Partial author list: First Author & Affiliation: Chen, Tao; Division of Genetic and Reproductive Toxicology, National Cnter for Toxicological Research, US Food and Drug Administration, Jefferson, AR, US. Release Date: 20080331. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-59454-664-9, Hardcover; 978-1-59454-664-8, Hardcover. Language: English. Major Descriptor: DNA; Genes; Mutations; Neoplasms. Minor Descriptor: Mice; Rats. Classification: Cancer (3293). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - Transgenic mouse and rat mutation assays have provided a tool for analyzing in vivo mutation in any tissue from which sufficient amounts of DNA can be recovered. Thus these assays provide a method for directly comparing cancer incidence with mutant frequency. In these systems, chromosomally-integrated transgenes are used as the targets for mutation. Following recovery of the transgenes, the target DNA can be assayed in vitro to identify and quantify mutations produced in vivo. In this article, we review progress in the development, validation, and use of transgenic in vivo mutation models. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - transgenic rodent mutation assays
KW - DNA mutation
KW - cancer
KW - transgenes
KW - 2007
KW - DNA
KW - Genes
KW - Mutations
KW - Neoplasms
KW - Mice
KW - Rats
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13965-004&site=ehost-live&scope=site
UR - rheflich@nctr.fda.gov
UR - nmei@nctr.fda.gov
UR - tchen@nctr.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Axume, Juan
AU - Smith, Steven S.
AU - Pogribny, Igor P.
AU - Moriarty, David J.
AU - Caudill, Marie A.
T1 - The methylenetetrahydrofolate reductase 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2007/01//
VL - 27
IS - 1
M3 - Article
SP - 13
EP - 17
SN - 02715317
AB - Abstract: DNA methylation is an epigenetic feature associated with X chromosome inactivation, genomic imprinting, transcriptional silencing of genes, and genomic stability. Folate provides a labile source of methyl groups that may be used for cellular methylation reactions, including DNA methylation. The methylenetetrahydrofolate reductase (MTHFR) 677C→T variant is an important determinant of folate nutriture and may influence DNA methylation. This study sought to assess the influence of the MTHFR C677T genotype on global leukocyte DNA methylation in young (age range = 18-45 years) Mexican American women (N = 43: CC, n = 14; CT, n = 12; TT, n = 17). Subjects consumed a folate-restricted diet (135 μg of dietary folate equivalents per day) for 7 weeks followed by folate treatment with 400 or 800 μg of dietary folate equivalents per day for another 7 weeks. Global leukocyte DNA methylation was assessed via the cytosine extension assay at weeks 0, 7 (after folate restriction), and 14 (after folate treatment). No main effect of MTHFR C677T genotype or folate intake was detected at any time point during the study. However, at the end of folate treatment (week 14), DNA methylation was lower (P < .05) among women with the MTHFR 677TT genotype than among those with the CT or CC genotype. Because it is unlikely that folate treatment would result in methyl group loss, we suggest that there was a delay in the DNA methylation response to folate intake. Overall, these data suggest that the MTHFR 677TT genotype and folate interact to lower global leukocyte DNA methylation patterns in young Mexican American women. [Copyright &y& Elsevier]
AB - Copyright of Nutrition Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - METHYLATION
KW - X chromosome
KW - GENOMICS
KW - GENETICS
KW - DNA methylation
KW - Folate
KW - Folic acid
KW - Human
KW - MTHFR
KW - Women
N1 - Accession Number: 23869154; Axume, Juan 1 Smith, Steven S. 2 Pogribny, Igor P. 3 Moriarty, David J. 4 Caudill, Marie A. 1; Email Address: macaudill@csupomona.edu; Affiliation: 1: Human Nutrition and Food Science Department, Cal Poly Pomona University, Pomona, CA 91768, USA 2: City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA 3: Division of Biochemical Toxicology, US Food and Drug Administration National Center for Toxicological Research, Jefferson, AR 72079, USA 4: Biological Sciences Department, Cal Poly Pomona University, Pomona, CA 91768, USA; Source Info: Jan2007, Vol. 27 Issue 1, p13; Subject Term: DNA; Subject Term: METHYLATION; Subject Term: X chromosome; Subject Term: GENOMICS; Subject Term: GENETICS; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Folate; Author-Supplied Keyword: Folic acid; Author-Supplied Keyword: Human; Author-Supplied Keyword: MTHFR; Author-Supplied Keyword: Women; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.nutres.2006.12.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23869154&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106199694
T1 - Food and Drug Administration Drug Approval Summary: Sunitinib Malate for the Treatment of Gastrointestinal Stromal Tumor and Advanced Renal Cell Carcinoma.
AU - Rock EP
AU - Goodman V
AU - Jiang JX
AU - Mahjoob K
AU - Verbois SL
AU - Morse D
AU - Gagher R
AU - Justice R
AU - Pazdur R
Y1 - 2007/01//
N1 - Accession Number: 106199694. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Antineoplastic Agents -- Therapeutic Use
KW - Carcinoma, Renal Cell -- Drug Therapy
KW - Drug Approval
KW - Gastrointestinal Neoplasms -- Drug Therapy
KW - Heterocyclic Compounds -- Therapeutic Use
KW - Indoles -- Therapeutic Use
KW - Kidney Neoplasms -- Drug Therapy
KW - United States Food and Drug Administration
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Antineoplastic Agents -- Administration and Dosage
KW - Antineoplastic Agents -- Adverse Effects
KW - Carcinoma, Renal Cell -- Pathology
KW - Clinical Trials
KW - Female
KW - Heterocyclic Compounds -- Administration and Dosage
KW - Heterocyclic Compounds -- Adverse Effects
KW - Indoles -- Administration and Dosage
KW - Indoles -- Adverse Effects
KW - Kidney Neoplasms -- Pathology
KW - Male
KW - Middle Age
KW - Patient Safety
KW - United States
SP - 107
EP - 113
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 12
IS - 1
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On January 26, 2006, sunitinib (Sutent) received regular approval as monotherapy for the treatment of patients with gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate (Gleevec). Time-to-tumor progression (TTP) of sunitinib-treated patients was superior to that of placebo-treated patients. Median TTP of sunitinib-treated patients was 27.3 weeks, compared with 6.4 weeks for placebo-treated patients (p< .0001). Partial responses were observed in 6.8% of sunitinib-treated patients and no placebo-treated patients. Sunitinib also received accelerated approval on January 26, 2006, as monotherapy for treatment of advanced renal cell carcinoma (RCC). In two single-arm trials of sunitinib in patients with metastatic RCC, partial responses were observed in 25.5% (95% confidence interval [CI], 17.5, 34.9) and 36.5% (95% CI, 24.7, 49.6) of patients. Median response durations in the two trials were 27.1 weeks (95% CI, 24.4, incalculable) and 54 weeks (95% CI, 34.3, 70.1). Treatment-emergent adverse events in sunitinib-treated patients included diarrhea, mucositis, skin abnormalities, altered taste, electrolyte abnormalities, hypertension, and diminution in left ventricular ejection fraction. Cardiac safety of sunitinib in patients with preexisting cardiac abnormalities remains unknown. Based on nonclinical findings, physicians prescribing sunitinib should monitor for adrenal insufficiency in patients who undergo stressors such as surgery, trauma, or severe infection. Caution should be exercised when administering sunitinib in combination with known CYP3A4 inducers or inhibitors.
SN - 1083-7159
AD - Division of Drug Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
U2 - PMID: 17227905.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106199694&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stefaniak, Aleksandr B.
AU - Hoover, Mark D.
AU - Dickerson, Robert M.
AU - Day, Gregory A.
AU - Breysse, Patrick N.
AU - Scripsick, Ronald C.
T1 - Differences in estimates of size distribution of beryllium powder materials using phase contrast microscopy, scanning electron microscopy, and liquid suspension counter techniques.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2007/01//
VL - 4
M3 - Article
SP - 3
EP - 6
PB - BioMed Central
SN - 17438977
AB - Accurate characterization of the physicochemical properties of aerosols generated for inhalation toxicology studies is essential for obtaining meaningful results. Great emphasis must also be placed on characterizing particle properties of materials as administered in inhalation studies. Thus, research is needed to identify a suite of techniques capable of characterizing the multiple particle properties (i.e., size, mass, surface area, number) of a material that may influence toxicity. The purpose of this study was to characterize the morphology and investigate the size distribution of a model toxicant, beryllium. Beryllium metal, oxides, and alloy particles were aerodynamically size-separated using an aerosol cyclone, imaged dry using scanning electron microscopy (SEM), then characterized using phase contrast microscopy (PCM), a liquid suspension particle counter (LPC), and computer-controlled SEM (CCSEM). Beryllium metal powder was compact with smaller sub-micrometer size particles attached to the surface of larger particles, whereas the beryllium oxides and alloy particles were clusters of primary particles. As expected, the geometric mean (GM) diameter of metal powder determined using PCM decreased with aerodynamic size, but when suspended in liquid for LPC or CCSEM analysis, the GM diameter decreased by a factor of two (p < 0.001). This observation suggested that the smaller submicrometer size particles attached to the surface of larger particles and/or particle agglomerates detach in liquid, thereby shifting the particle size distribution downward. The GM diameters of the oxide materials were similar regardless of sizing technique, but observed differences were generally significant (p < 0.001). For oxides, aerodynamic cluster size will dictate deposition in the lung, but primary particle size may influence biological activity. The GM diameter of alloy particles determined using PCM became smaller with decreasing aerodynamic size fraction; however, when suspended in liquid for CCSEM and LPC analyses, GM particle size decreased by a factor of two (p < 0.001) suggesting that alloy particles detach in liquid. Detachment of particles in liquid could have significance for the expected versus actual size (and number) distribution of aerosol delivered to an exposure subject. Thus, a suite of complimentary analytical techniques may be necessary for estimating size distribution. Consideration should be given to thoroughly understanding the influence of any liquid vehicle which may alter the expected aerosol size distribution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisonous gases -- Toxicology
KW - Toxicity testing
KW - Aerosol therapy
KW - Beryllium compounds
KW - Scanning electron microscopes
N1 - Accession Number: 28783535; Stefaniak, Aleksandr B. 1,2,3; Email Address: astefaniak@cdc.gov; Hoover, Mark D. 1; Email Address: mhoover1@cdc.gov; Dickerson, Robert M. 3; Email Address: dickerson@lanl.gov; Day, Gregory A. 1; Email Address: gday@cdc.gov; Breysse, Patrick N. 2; Email Address: pbreysse@jhsph.edu; Scripsick, Ronald C. 3; Email Address: scrip@lanl.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Mailstop H-2703, 1095 Willowdale Road, Morgantown, WV, 26505, USA; 2: Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA; 3: Los Alamos National Laboratory, Los Alamos, NM 87545, USA; Issue Info: 2007, Vol. 4, p3; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Toxicity testing; Subject Term: Aerosol therapy; Subject Term: Beryllium compounds; Subject Term: Scanning electron microscopes; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1186/1743-8977-4-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=28783535&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mossman, Brooke T.
AU - Borm, Paul J.
AU - Castranova, Vincent
AU - Costa, Daniel L.
AU - Donaldson, Kenneth
AU - Kleeberger, Steven R.
T1 - Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2007/01//
VL - 4
M3 - Article
SP - 4
EP - 10
PB - BioMed Central
SN - 17438977
AB - Background: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health. Results: The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates. Conclusion: New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisonous gases -- Toxicology
KW - Silica dust
KW - Cardiovascular diseases
KW - Lung diseases
KW - Nanoparticles
N1 - Accession Number: 28783536; Mossman, Brooke T. 1; Email Address: brooke.mossman@uvm.edu; Borm, Paul J. 2; Email Address: P.Borm@HSZuyd.nl; Castranova, Vincent 3; Email Address: vic1@cdc.gov; Costa, Daniel L. 4; Email Address: Costa.Dan@epa.gov; Donaldson, Kenneth 5; Email Address: ken.donaldson@ed.ac.uk; Kleeberger, Steven R. 6; Email Address: kleeber1@niehs.nih.gov; Affiliations: 1: Department of Pathology, University of Vermont, 89 Beaumont Avenue, HSRF 218, Burlington, VT 05405, USA; 2: University of Heerlen, CEL, Nieuw Eyckholt 300, Heerlen, 6400 AN, The Netherlands; 3: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA; 4: Environmental Protection Agency, E205-09, EPA/ORD, Research Triangle Park, NC 27711, USA; 5: Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK; 6: National Institute of Environmental Health Sciences, MD D2-01, P. O. Box 12233, Research Triangle Park, NC 27709, USA; Issue Info: 2007, Vol. 4, p4; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Silica dust; Subject Term: Cardiovascular diseases; Subject Term: Lung diseases; Subject Term: Nanoparticles; Number of Pages: 10p; Document Type: Article
L3 - 10.1186/1743-8977-4-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=28783536&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Kok, Gerjo
AU - de Zwart, Onno
AU - Schaalma, Herman
T1 - AIDS 2006 – time to deliver
JO - Patient Education & Counseling
JF - Patient Education & Counseling
Y1 - 2007/01//
VL - 65
IS - 1
M3 - Editorial
SP - 1
EP - 2
SN - 07383991
N1 - Accession Number: 23280644; Kok, Gerjo 1; Email Address: g.kok@psychology.unimaas.nl de Zwart, Onno 2 Schaalma, Herman 1; Affiliation: 1: Maastricht University, Department Applied and Social Psychology, Maastricht, The Netherlands 2: Municipal Public Health Service Rotterdam, The Netherlands; Source Info: Jan2007, Vol. 65 Issue 1, p1; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.pec.2006.10.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23280644&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - M.-L. Chen
AU - A. Straughn
AU - N. Sadrieh
AU - M. Meyer
AU - P. Faustino
AU - A. Ciavarella
AU - B. Meibohm
AU - C. Yates
T1 - A Modern View of Excipient Effects on Bioequivalence: Case Study of Sorbitol.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2007/01//
VL - 24
IS - 1
M3 - Article
SP - 73
EP - 80
SN - 07248741
AB - AbstractPurpose??To examine the effect of common excipients such as sugars (sorbitolversussucrose) on bioequivalence between pharmaceutical formulations, using ranitidine and metoprolol as model drugs.Methods??Two single-dose, replicated, crossover studies were first conducted in healthy volunteers (N?=?20 each) to compare the effect of 5?Gm of sorbitol and sucrose on bioequivalence of 150?mg ranitidine or 50?mg metoprolol in aqueous solution, followed by a single-dose, nonreplicated, crossover study (N?=?24) to determine the threshold of sorbitol effect on bioequivalence of 150?mg ranitidine in solution.Results??Ranitidine Cmax and AUC(0??) were decreased by ?50% and 45%, respectively, in the presence of sorbitolversussucrose. Similarly, sorbitol reduced metoprolol Cmax by 23% but had no significant effect on AUC(0??). An appreciable subject-by-formulation interaction was found for ranitidine Cmax and AUC(0??), as well as metoprolol Cmax. Sorbitol decreased the systemic exposure of ranitidine in a dose-dependent manner and affected bioequivalence at a level of 1.25?Gm or greater.Conclusions??As exemplified by sorbitol, some common excipients have unexpected effect on bioavailability/bioequivalence, depending on the pharmacokinetic characteristics of the drug, as well as the type and amount of the excipient present in the formulation. More research is warranted to examine other ?common? excipients that may have unintended influence on bioavailability/bioequivalence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Therapeutic equivalency
KW - SORBITOL
KW - RANITIDINE
KW - PHARMACOKINETICS
N1 - Accession Number: 23707695; M.-L. Chen 1 A. Straughn 2 N. Sadrieh 3 M. Meyer 4 P. Faustino 3 A. Ciavarella 3 B. Meibohm 2 C. Yates 2; Affiliation: 1: Food and Drug Administration Office of Pharmaceutical Science, Center for Drug Evaluation and Research 10903 New Hampshire Avenue Building 21, Rm. 3644 Silver Spring Maryland 20993-0002 USA 10903 New Hampshire Avenue Building 21, Rm. 3644 Silver Spring Maryland 20993-0002 USA 2: University of Tennessee Health Science Center 874 Union Avenue Memphis Tennessee 38163 USA 874 Union Avenue Memphis Tennessee 38163 USA 3: Food and Drug Administration 10903 New Hampshire Avenue, Life Sciences Building 64 Silver Spring Maryland 20993-0002 USA 10903 New Hampshire Avenue, Life Sciences Building 64 Silver Spring Maryland 20993-0002 USA 4: 1700 SW 6th Ave. Boca Raton Florida 33486 USA 1700 SW 6th Ave. Boca Raton Florida 33486 USA; Source Info: Jan2007, Vol. 24 Issue 1, p73; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: SORBITOL; Subject Term: RANITIDINE; Subject Term: PHARMACOKINETICS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Vernon, John A.
T1 - Letter From the Commissioner’s Office at the US FDA.
JO - PharmacoEconomics
JF - PharmacoEconomics
Y1 - 2007/01//
VL - 25
IS - 1
M3 - Editorial
SP - 1
EP - 2
PB - Springer Science & Business Media B.V.
SN - 11707690
AB - Economic modelling is increasingly being used to evaluate the cost effectiveness of health technologies. One of the requirements for good practice in modelling is appropriate application of rates and probabilities. In spite of previous descriptions of appropriate use of rates and probabilities, confusions persist beyond a simple understanding of their definitions. The objective of this article is to provide a concise guide to understanding the issues surrounding the use of rates and probabilities reported in the literature in economic models, and an understanding of when and how to transform them appropriately. The article begins by defining rates and probabilities and shows the essential difference between the two measures. Appropriate conversions between rates and probabilities are discussed, and simple examples are provided to illustrate the techniques and pitfalls. How the transformed rates and probabilities may be used in economic models is then described and some recommendations are suggested. [ABSTRACT FROM AUTHOR]
AB - Copyright of PharmacoEconomics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ECONOMIC models
KW - MEDICAL technology
KW - COST effectiveness
KW - PROBABILITY measures
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 23686584; Vernon, John A. 1; Email Address: john.vernon@fda.hhs.gov; Affiliation: 1: US Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2007, Vol. 25 Issue 1, p1; Subject Term: ECONOMIC models; Subject Term: MEDICAL technology; Subject Term: COST effectiveness; Subject Term: PROBABILITY measures; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morrato, Elaine H.
AU - Staffa, Judy A.
T1 - Effectiveness of risk management plans: a case study of pemoline using pharmacy claims data.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/01//
VL - 16
IS - 1
M3 - Article
SP - 104
EP - 112
SN - 10538569
AB - Purpose To assess the effectiveness of a pharmaceutical risk management plan using pemoline as a case study and pharmacy claims as the data source. Methods Prescription claims from a continuously enrolled US population (September 1, 2000-September 30, 2002) from Caremark, a pharmacy benefit manager, were evaluated for patients with one or more pemoline claims. Patients were categorized using pemoline as second-line or first-line therapy depending on presence or absence of other central nervous system (CNS) stimulants prescriptions 90 days prior to the first pemoline claim. Logistic regression was performed to compare second-line and first-line usage with regard to patient age, gender and prescribing physician specialty and region of practice. Results Of 1 279 296 prescription claims for CNS stimulants, 17 256 (1.3%) were for pemoline. Nine hundred thirteen patients received pemoline and had 90 days or more prior enrollment. Overall, 10% of patients receiving pemoline received it as second-line therapy (95%CI: 8-12%). After adjusting for age, gender, specialty, and region, the odds of receiving pemoline as second-line therapy were significantly greater in pediatrics relative to adults (OR = 2.82, 95%CI: 1.58-5.03), and among those whose prescribers were psychiatrists versus primary care physicians (OR = 2.48, 95%CI: 1.37-4.50). Children treated by a psychiatrist had the greatest likelihood for use as second-line therapy (36%, 95%CI: 19-56%). Conclusions Among patients who received pemoline, concordance with second-line therapy recommendations was low, even among the primary target audience of children. These results in a large geographically diverse patient population are consistent with an earlier regional study. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64726816; Morrato, Elaine H. 1; Staffa, Judy A. 2; Affiliations: 1: University of Colorado at Denver and Health Sciences Center, Denver, CO, USA; 2: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Drug Safety, Rockville, MD, USA; Issue Info: Jan2007, Vol. 16 Issue 1, p104; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1279
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2006-08267-002
AN - 2006-08267-002
AU - Brounstein, Paul J.
AU - Gardner, Stephen E.
AU - Backer, Thomas E.
ED - Tolan, Patrick
ED - Szapocznik, José
ED - Sambrano, Soledad
ED - Tolan, Patrick, (Ed)
ED - Szapocznik, José, (Ed)
ED - Sambrano, Soledad, (Ed)
T1 - Research to Practice: Bringing Effective Prevention to Every Community.
T2 - Preventing youth substance abuse: Science-based programs for children and adolescents.
Y1 - 2007///
SP - 41
EP - 64
CY - Washington, DC, US
PB - American Psychological Association
SN - 1-59147-307-1
SN - 978-1-59147-307-7
N1 - Accession Number: 2006-08267-002. Partial author list: First Author & Affiliation: Brounstein, Paul J.; Center for Mental Health Services, Rockville, MD, US. Release Date: 20060705. Correction Date: 20150824. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-59147-307-1, Hardcover; 978-1-59147-307-7, Hardcover. Language: English. Major Descriptor: Adolescent Development; Drug Abuse Prevention; Evidence Based Practice; Family Intervention; School Based Intervention. Minor Descriptor: Community Services; Government Programs. Classification: Drug & Alcohol Rehabilitation (3383); Educational/Vocational Counseling & Student Services (3580). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24.
AB - Getting evidence-based drug abuse prevention programs implemented in local communities is always a challenge. The first hurdle is to find what works. As this volume and several other reviews attest, there is growing evidence of many efficacious preventive interventions for substance abuse (e.g., Jacobs & Brounstein, 2002). For example, in a study of more than 10,000 children ages 10 to 17 years participating in 48 programs, prevention programs were shown to play a clear role in reducing youth substance use and delaying onset of use (Springer, Sambrano, Sale, Kasim, & Hermann, 2002). As an example, the National Registry of Effective Programs and Practices (NREPP) has identified more than 100 effective programs, 52 of which are fully ready for wider dissemination. Once programs are identified, the challenge is moving them into the community. This chapter discusses approaches used at the Substance Abuse and Mental Health Service Administration's Center for Substance Abuse Prevention (CSAP) to facilitate local implementation of evidence-based substance abuse prevention programs for youths. In doing so, our intent is to illustrate key issues in overcoming the hurdle of translating research to practice. We first provide an extended case example of the progress from development and testing to implementation and transfer of technology of a program identified as a model program by CSAP: the Families and Schools Together (FAST). In this chapter, we have chosen to concentrate on describing the experience of a community service provider in implementing FAST, rather than on the details of the program itself. Then we discuss the issues related to these processes more generally. The chapter ends by considering what role CSAP and other research entities can play in helping states, communities, schools, and prevention agencies meet these challenges and what next steps might help to expand that role. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - youth drug abuse prevention research
KW - community prevention
KW - SAMHSA
KW - CSAP
KW - evidence based practice
KW - Families and Schools Together program
KW - 2007
KW - Adolescent Development
KW - Drug Abuse Prevention
KW - Evidence Based Practice
KW - Family Intervention
KW - School Based Intervention
KW - Community Services
KW - Government Programs
KW - 2007
DO - 10.1037/11488-002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-08267-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106287785
T1 - Cost shifting under managed behavioral health care.
AU - Zuvekas SH
AU - Rupp A
AU - Norquist G
Y1 - 2007/01//
N1 - Accession Number: 106287785. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9502838.
KW - Drug Therapy -- Economics
KW - Health Care Costs
KW - Health Maintenance Organizations -- Administration
KW - Health Maintenance Organizations -- Economics
KW - Mental Disorders -- Economics
KW - Mental Disorders -- Therapy
KW - Mental Health Services -- Administration
KW - Mental Health Services -- Economics
KW - Adult
KW - Confidence Intervals
KW - Cost Benefit Analysis
KW - Costs and Cost Analysis
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Mental Disorders -- Drug Therapy
KW - Multivariate Analysis
KW - P-Value
KW - Panel Studies
KW - T-Tests
KW - United States
KW - Human
SP - 100
EP - 108
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 58
IS - 1
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: The study examined whether a managed behavioral health care organization (MBHO) shifted treatment costs. METHODS: Four years of claims data (1991-1995) from an insurer that introduced an MBHO in 1992 to control treatment costs were analyzed. Although the MBHO was not at direct financial risk for specialty mental health treatment, it faced incentives related to reputation and contract renewal to shift costs to primary care treatment or prescription drugs. It was hypothesized that if cost shifting occurred, an increase would be noted in the use of psychotropic medications without concurrent use of specialty mental health treatment. Simple t tests and a generalized estimating equations probit specification were used to test this hypothesis. Separate tests were performed for use of any psychotropic medication, any newer antidepressant, and any stimulant in a large employer group that simultaneously implemented parity coverage (75,360 enrollees) and a group of smaller employers that did not (9,228 enrollees). RESULTS: The use of any psychotropic medication rose 64% in relative terms (p<.001) over the four-year period among enrollees of the large employer group and by 87% in the smaller groups (p<.001). In general, there were downward secular trends in the use of psychotropic medications without specialty care. Introduction of the MBHO was not significantly associated with the use of psychotropic medication alone. For newer antidepressants, introduction of the MBHO was associated in the large group with a 2.4 (p=.003) absolute percentage point decrease in medication use alone. CONCLUSIONS: No evidence was found to suggest that the MBHO shifted treatment costs.
SN - 1075-2730
AD - Center for Financing Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD 20850, USA. szuvekas@ahrq.gov
U2 - PMID: 17215419.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2006-23305-001
AN - 2006-23305-001
AU - Fisher, William H.
ED - Fisher, William H.
ED - Fisher, William H., (Ed)
T1 - Introduction: Children, adolescents, and mental health services research: An overview of emerging perspective.
T2 - Research on community-based mental health services for children and adolescents.
T3 - Research in community and mental health; Vol 14; ISSN: 0192-0812 (Print)
Y1 - 2007///
VL - 14
SP - 1
EP - 9
CY - US
PB - Elsevier Science/JAI Press
SN - 0192-0812
SN - 0-7623-1315-3
SN - 978-0-7623-1315-0
N1 - Accession Number: 2006-23305-001. Partial author list: First Author & Affiliation: Fisher, William H.; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080414. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-1315-3, Hardcover; 978-0-7623-1315-0, Hardcover. Language: English. Major Descriptor: Experimentation; Mental Health Services; Health Care Policy. Minor Descriptor: Mental Disorders. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 9.
AB - In general, it can be said that the care and treatment of children and adolescents has gone forward in a regulatory environment that is much different from that focused on adults. Social welfare policy also views children and adults differently for a variety of purposes, important among them the determination of eligibility for benefits provided under various entitlement programs. The co-evolution of social welfare policy and the definitional regimes of psychiatric/psychological subspecialties with regard to children and adults has led to significant differences in the management of their psychiatric disorders. This chapter discusses research on mental services for children and adolescents and introduces the remaining chapters in the volume. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social welfare policy
KW - mental health services
KW - children
KW - adolescents
KW - research
KW - 2007
KW - Experimentation
KW - Mental Health Services
KW - Health Care Policy
KW - Mental Disorders
KW - 2007
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-23305-004
AN - 2006-23305-004
AU - Davis, Maryann
AU - Koroloff, Nancy
ED - Fisher, William H.
ED - Fisher, William H., (Ed)
T1 - The great divide: How mental health policy fails young adults.
T2 - Research on community-based mental health services for children and adolescents.
T3 - Research in community and mental health; Vol 14; ISSN: 0192-0812 (Print)
Y1 - 2007///
VL - 14
SP - 53
EP - 74
CY - US
PB - Elsevier Science/JAI Press
SN - 0192-0812
SN - 0-7623-1315-3
SN - 978-0-7623-1315-0
N1 - Accession Number: 2006-23305-004. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080414. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-1315-3, Hardcover; 978-0-7623-1315-0, Hardcover. Language: English. Major Descriptor: Emotional Disturbances; Mental Disorders; Mental Health Services; Health Care Policy. Minor Descriptor: Psychodiagnostic Typologies. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - The present study describes age-based definitional agreement and disagreement at the state and federal level: (1) between the federal definitions of serious emotional disturbance (SED) and serious mental illness (SMI) put forth by the Center for Mental Health Services (CMHS) and (2) between state population definitions for adult and child mental health systems. Through analysis of federal and state-level policies, we explore the impact of age-based population policies on care continuity for youth from the child system as they age into adulthood. The present study was initiated as part of a larger study to determine the status of transition support development in state child mental health systems and is described in Davis and Sondheimer (2005). This chapter discusses federal definitions of SED and SMI; state definitions; diagnostic comparability; functional comparability; corrective policies; methodological limitations; consequences of age-based discrepancies; and remedies. The chapter ends with a concluding discussion of categorization of policies and programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health policy
KW - young adults
KW - age-based policies
KW - serious emotional disturbance
KW - serious mental illness
KW - definitions
KW - mental health systems
KW - categorization
KW - 2007
KW - Emotional Disturbances
KW - Mental Disorders
KW - Mental Health Services
KW - Health Care Policy
KW - Psychodiagnostic Typologies
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: 0990-0115. Other Details: Through the American Institutes of Research. Recipients: No recipient indicated
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-23305-009
AN - 2006-23305-009
AU - Biebel, Kathleen
AU - Geller, Jeffrey L.
ED - Fisher, William H.
ED - Fisher, William H., (Ed)
T1 - Challenges for a system of care.
T2 - Research on community-based mental health services for children and adolescents.
T3 - Research in community and mental health; Vol 14; ISSN: 0192-0812 (Print)
Y1 - 2007///
VL - 14
SP - 179
EP - 199
CY - US
PB - Elsevier Science/JAI Press
SN - 0192-0812
SN - 0-7623-1315-3
SN - 978-0-7623-1315-0
N1 - Accession Number: 2006-23305-009. Partial author list: First Author & Affiliation: Biebel, Kathleen; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080414. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7623-1315-3, Hardcover; 978-0-7623-1315-0, Hardcover. Language: English. Major Descriptor: Health Care Delivery; Mental Health Services; Treatment Outcomes. Minor Descriptor: Emotional Disturbances. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - 'System of care' has become the buzzword for contemporary child and adolescent services. Despite the fact that findings of studies of child and family outcomes associated with system of care have been disappointing (Evans & Armstrong, 2005), systems of care are at the forefront of service delivery for children and adolescents with serious emotional disturbances (SED). Systems of care, however, are not without controversy. This chapter will explore various macro and micro level challenges currently facing the system of care movement. At the macro and systems level, challenges include meeting the needs of the high-risk population of children and adolescents traditionally served by systems of care, and securing cooperation and collaboration from multiple child serving systems. At the micro and practice level, challenges include financing systems of care, shortages of mental health services and staff, and incorporating inpatient psychiatric care into a community-based treatment model. These challenges are highlighted by findings from empirical investigations of systems of care and other interventions for children and adolescents with SED. Finally, future implications for systems of care will be discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - system of care
KW - service delivery
KW - serious emotional disturbances
KW - children
KW - adolescents
KW - outcomes
KW - 2007
KW - Health Care Delivery
KW - Mental Health Services
KW - Treatment Outcomes
KW - Emotional Disturbances
KW - 2007
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Geskus, Ronald B.
AU - Prins, Maria
AU - Hubert, Jean-Baptiste
AU - Miedema, Frank
AU - Berkhout, Ben
AU - Rouzioux, Christine
AU - Delfraissy, Jean-Francois
AU - Meyer, Laurence
T1 - The HIV RNA setpoint theory revisited.
JO - Retrovirology
JF - Retrovirology
Y1 - 2007/01//
VL - 4
M3 - Article
SP - 65
EP - 73
PB - BioMed Central
SN - 17424690
AB - Background: The evolution of plasma viral load after HIV infection has been described as reaching a setpoint, only to start rising again shortly before AIDS diagnosis. In contrast, CD4 T-cell count is considered to show a stable decrease. However, characteristics of marker evolution over time depend on the scale that is used to visualize trends. In reconsidering the setpoint theory for HIV RNA, we analyzed the evolution of CD4 T-cell count and HIV-1 RNA level from HIV seroconversion to AIDS diagnosis. Follow-up data were used from two cohort studies among homosexual men (N = 400), restricting to the period before highly active antiretroviral therapy became widely available (1984 until 1996). Individual trajectories of both markers were fitted and averaged, both from seroconversion onwards and in the four years preceding AIDS diagnosis, using a bivariate random effects model. Both markers were evaluated on a scale that is directly related to AIDS risk. Results: Individuals with faster AIDS progression had higher HIV RNA level six months after seroconversion. For CD4 T-cell count, this ordering was less clearly present. However, HIV RNA level and CD4 T-cell count showed qualitatively similar evolution over time after seroconversion, also when stratified by rate of progression to AIDS. In the four years preceding AIDS diagnosis, a non-significant change in HIV RNA increase was seen, whereas a significant biphasic pattern was present for CD4 T-cell decline. Conclusion: HIV RNA level has more setpoint behaviour than CD4 T-cell count as far as the level shortly after seroconversion is concerned. However, with respect to the, clinically more relevant, marker evolution over time after seroconversion, a setpoint theory holds as much for CD4 T-cell count as for HIV RNA level. [ABSTRACT FROM AUTHOR]
AB - Copyright of Retrovirology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - RNA
KW - VIRAL load
KW - HIV (Viruses)
KW - ANTIVIRAL agents
KW - T cells
N1 - Accession Number: 34984794; Geskus, Ronald B. 1,2; Email Address: statistics@inter.nl.net Prins, Maria 1,3; Email Address: mprins@ggd.amsterdam.nl Hubert, Jean-Baptiste 4,5,6; Email Address: hubert@vjf.inserm.fr Miedema, Frank 7; Email Address: f.miedema@umcutrecht.nl Berkhout, Ben 8; Email Address: b.berkhout@amc.uva.nl Rouzioux, Christine 9; Email Address: christine.rouzioux@nck.ap-hopparis.fr Delfraissy, Jean-Francois 6; Email Address: jean-francois.delfraissy@bct.ap-hop-paris.fr Meyer, Laurence 4,5,7; Email Address: meyer@vjf.inserm.fr; Affiliation: 1: Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands 2: Cluster Infectious Diseases, Department of Research, Amsterdam Health Service, Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands 3: Department of Internal Medicine, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands 4: 4Inserm, U822, Le Kremlin-Bicêtre, F-94276, France 5: AP-HP, Hopital Bicêtre, Epidemiology and Public Health Service, F-94276, France 6: Univ Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, F-94276, France 7: Department of Immunology, University Medical Center, Utrecht, The Netherlands 8: Department of Human Retrovirology, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands 9: Department of Virology, Hôpital Necker, Paris, France; Source Info: 2007, Vol. 4, p65; Subject Term: HIV infections; Subject Term: RNA; Subject Term: VIRAL load; Subject Term: HIV (Viruses); Subject Term: ANTIVIRAL agents; Subject Term: T cells; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1186/1742-4690-4-65
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flemmer, Michael M.
AU - Ham, Jason E.
AU - Wells, J. R.
T1 - Field and laboratory emission cell automation and control system for investigating surface chemistry reactions.
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
Y1 - 2007/01//
VL - 78
IS - 1
M3 - Article
SP - 014101
PB - American Institute of Physics
SN - 00346748
AB - A novel system [field and laboratory emission cell (FLEC) automation and control system] has been developed to deliver ozone to a surface utilizing the FLEC to simulate indoor surface chemistry. Ozone, humidity, and air flow rate to the surface were continuously monitored using an ultraviolet ozone monitor, humidity, and flow sensors. Data from these sensors were used as feedback for system control to maintain predetermined experimental parameters. The system was used to investigate the chemistry of ozone with α-terpineol on a vinyl surface over 72 h. Keeping all other experimental parameters the same, volatile organic compound emissions from the vinyl tile with α-terpineol were collected from both zero and 100 ppb (parts per 109) ozone exposures. System stability profiles collected from sensor data indicated experimental parameters were maintained to within a few percent of initial settings. Ozone data from eight experiments at 100 ppb (over 339 h) provided a pooled standard deviation of 1.65 ppb and a 95% tolerance of 3.3 ppb. Humidity data from 17 experiments at 50% relative humidity (over 664 h) provided a pooled standard deviation of 1.38% and a 95% tolerance of 2.77%. Data of the flow rate of air flowing through the FLEC from 14 experiments at 300 ml/min (over 548 h) provided a pooled standard deviation of 3.02 ml/min and a 95% tolerance range of 6.03 ml/min. Initial experimental results yielded long term emissions of ozone/α-terpineol reaction products, suggesting that surface chemistry could play an important role in indoor environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Review of Scientific Instruments is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER integrated manufacturing systems
KW - CHEMICAL tests & reagents
KW - INDUSTRIAL engineering
KW - OZONE
KW - VOLATILE organic compounds
KW - EMISSIONS (Air pollution)
KW - STANDARD deviations
KW - SURFACE chemistry
N1 - Accession Number: 24601948; Flemmer, Michael M. 1 Ham, Jason E. 1 Wells, J. R. 1; Affiliation: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505; Source Info: Jan2007, Vol. 78 Issue 1, p014101; Subject Term: COMPUTER integrated manufacturing systems; Subject Term: CHEMICAL tests & reagents; Subject Term: INDUSTRIAL engineering; Subject Term: OZONE; Subject Term: VOLATILE organic compounds; Subject Term: EMISSIONS (Air pollution); Subject Term: STANDARD deviations; Subject Term: SURFACE chemistry; Number of Pages: 7p; Illustrations: 3 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1063/1.2432243
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2007-03642-003
AN - 2007-03642-003
AU - Huang, Larke N.
AU - Isaacs, Mareasa R.
ED - Perry, Deborah F.
ED - Kaufmann, Roxane K.
ED - Knitzer, Jane
ED - Perry, Deborah F., (Ed)
ED - Kaufmann, Roxane K., (Ed)
ED - Knitzer, Jane, (Ed)
T1 - Early childhood mental health: A focus on culture and context.
T2 - Social and emotional health in early childhood: Building bridges between services and systems.
Y1 - 2007///
SP - 37
EP - 59
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 978-155766782-3
SN - 1-55766-782-9
N1 - Accession Number: 2007-03642-003. Partial author list: First Author & Affiliation: Huang, Larke N.; Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20070702. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-155766782-3, Paperback; 1-55766-782-9, Paperback. Language: English. Major Descriptor: Early Childhood Development; Family; Mental Health; Sociocultural Factors. Classification: Psychosocial & Personality Development (2840). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23.
AB - The focus of this chapter is on the interaction of cultural and contextual factors that have an impact on the development of young children and are critical to understanding early childhood mental health. The key messages in this chapter are as follows: Changing population demographics make it imperative to grasp the significance of diversity and culture in U.S. society; Culture and context are key determinants in shaping family and child development and drive the need to expand existing models of child development; Sociocultural and contextual factors influence the mental health and the salient risk and protective factors for young children; Culture plays a role in how families interface with early childhood structures and caregiving systems; and Promotion, prevention, early identification and treatment interventions, and policies need to consider the cultural context of the young child and family. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - early childhood mental health
KW - cultural factors
KW - contextual factors
KW - family
KW - 2007
KW - Early Childhood Development
KW - Family
KW - Mental Health
KW - Sociocultural Factors
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-03642-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2007-02161-023
AN - 2007-02161-023
AU - Horn, Wade
ED - Loveless, A. Scott
ED - Holman, Thomas B.
ED - Loveless, A. Scott, (Ed)
ED - Holman, Thomas B., (Ed)
T1 - My Family Story.
T2 - The family in the new millennium: World voices supporting the natural clan, Vol 3: Strengthening the family.
Y1 - 2007///
SP - 332
EP - 340
CY - Westport, CT, US
PB - Praeger Publishers/Greenwood Publishing Group
SN - 0-275-99242-X
SN - 978-0-275-99242-2
N1 - Accession Number: 2007-02161-023. Partial author list: First Author & Affiliation: Horn, Wade; United States Department of Health and Human Services, Washington, DC, US. Release Date: 20070618. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-275-99242-X, Hardcover; 978-0-275-99242-2, Hardcover. Language: English. Conference Information: World Congress of Families III, Mar, 2004, Mexico City, Mexico. Major Descriptor: Father Absence; Marriage. Classification: Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 9.
AB - My parents just celebrated their fifty-fourth wedding anniversary. But that is not the remarkable part. You see, John and Daisy Horn had seven children. Today every one of them is married with children--and all to their first spouse. I learned about healthy marriages not just from my own parents, but also from their parents--my grandparents. Too many people grow up without having, like my family, the benefit of parents and grandparents who were each relatively happily married for over fifty years. The loss of this kind of marriage, and the detrimental effects this loss has on children, families, and communities, is why many are concerned about the fact that so many children are growing up in homes without both their mother and father. Why is marriage so important that its growing absence should be of such concern? Marriage is important for a number of reasons. One very important reason is because marriage is the institution which, throughout the ages and across all known cultures, has best bound men to families and their children. A retreat from marriage also means a retreat from responsible fatherhood. The United States has begun to take action to address the problem of father absence by strengthening marriage. I would like to convey some of the lessons we have learned in promoting healthy marriage in America, and describe how those lessons have informed the initiatives we have undertaken. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - father absence
KW - marriage
KW - US
KW - 2007
KW - Father Absence
KW - Marriage
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02161-023&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2006-22911-008
AN - 2006-22911-008
AU - Rawson, Richard A.
AU - Marinelli-Casey, Patricia
AU - Anglin, M. Douglas
AU - Dickow, Alice
AU - Frazier, Yvonne
AU - Gallagher, Cheryl
AU - Galloway, Gantt P.
AU - Herrell, James
AU - Huber, Alice
AU - McCann, Michael J.
AU - Obert, Jeanne
AU - Pennell, Susan
AU - Reiber, Chris
AU - Vandersloot, Denna
AU - Zweben, Joan
ED - Covey, Herbert C.
ED - Covey, Herbert C., (Ed)
T1 - A multisite comparison of psychosocial approaches for the treatment of methamphetamine dependence.
T2 - The methamphetamine crisis: Strategies to save addicts, families, and communities.
Y1 - 2007///
SP - 119
EP - 135
CY - Westport, CT, US
PB - Praeger Publishers/Greenwood Publishing Group
SN - 0-275-99322-1
SN - 978-0275993221
AD - Rawson, Richard A., UCLA Integrated Substance Abuse Programs, 1640 S. Sepulveda Blvd, Suite 200, Los Angeles, CA, US, 90025
N1 - Accession Number: 2006-22911-008. Partial author list: First Author & Affiliation: Rawson, Richard A.; University of California, Integrated Substance Abuse Programs, Los Angeles, CA, US. Release Date: 20080630. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-275-99322-1, Hardcover; 978-0275993221, Hardcover. Language: English. Major Descriptor: Biopsychosocial Approach; Drug Abuse; Drug Therapy; Methamphetamine. Minor Descriptor: Drug Rehabilitation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). Page Count: 17.
AB - This reprinted article originally appeared in Addiction, 2004(Jun), 99(6), 708. (The following abstract of the original article appeared in record [rid]2004-14418-006[/rid].) Aims: The Center for Substance Abuse Treatment (CSAT) Methamphetamine Treatment Project (MTP) is the largest randomized clinical trial of treatments for methamphetamine (MA) dependence to date. The objective of the study was to compare the Matrix Model, a manualized treatment method, with treatment-as-usual (TAU) in eight community out-patient settings in the Western United States. Design: Over an 18-month period between 1999 and 2001, 978 treatment-seeking, MA-dependent people were randomly assigned to receive either TAU at each site or a manualized 16-week treatment (Matrix Model). Setting: The study was conducted as an eight-site out-patient trial, with six sites located in California and one each in Montana and Hawaii. Findings: In the overall sample, and in the majority of sites, those who were assigned to Matrix treatment attended more clinical sessions, stayed in treatment longer, provided more MA-free urine samples during the treatment period and had longer periods of MA abstinence than those assigned to receive TAU. Measures of drug use and functioning collected at treatment discharge and 6 months post-admission indicate significant improvement by participants in all sites and conditions when compared to baseline levels, but the superiority of the Matrix approach did not persist at these two timepoints. Conclusions: Study results demonstrate a significant initial step in documenting the efficacy of the Matrix approach. Although the superiority of the Matrix approach over TAU was not maintained at the post-treatment timepoints, the in-treatment benefit is an important demonstration of empirical support for this psychosocial treatment approach. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methamphetamine dependence
KW - treatment-as-usual
KW - psychosocial approach
KW - 2007
KW - Biopsychosocial Approach
KW - Drug Abuse
KW - Drug Therapy
KW - Methamphetamine
KW - Drug Rehabilitation
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22911-008&site=ehost-live&scope=site
UR - matrixex@ucla.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2007-01027-006
AN - 2007-01027-006
AU - Williams, Christine G.
ED - Shore, David A.
ED - Shore, David A., (Ed)
T1 - Assessing quality: Today's data and a research agenda.
T2 - The trust crisis in healthcare: Causes, consequences, and cures.
Y1 - 2007///
SP - 70
EP - 76
CY - New York, NY, US
PB - Oxford University Press
SN - 0-19-517636-7
SN - 978-0-19-517636-0
N1 - Accession Number: 2007-01027-006. Partial author list: First Author & Affiliation: Williams, Christine G.; Office of Communications and Knowledge Transfer, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, US. Release Date: 20070730. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-19-517636-7, Hardcover; 978-0-19-517636-0, Hardcover. Language: English. Major Descriptor: Health Care Delivery; Health Care Services; Trust (Social Behavior); Health Care Administration; Quality of Services. Minor Descriptor: Client Attitudes; Organizations. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Intended Audience: Psychology: Professional & Research (PS). Page Count: 7.
AB - If trust in the healthcare system has eroded--and there is good evidence that it has--what are the immediate causes, the trust busters? And what can be done to rebuild trust? The U.S. Agency for Healthcare Research and Quality (AHRQ) and other organizations have sponsored research over the years to address these questions. But there are still many questions for which we have no answers, and which need to be the focus of future research. This chapter reviews the trust busters and the trust builders and addresses some of these questions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality assessment
KW - healthcare system
KW - trust busters
KW - rebuild trust
KW - 2007
KW - Health Care Delivery
KW - Health Care Services
KW - Trust (Social Behavior)
KW - Health Care Administration
KW - Quality of Services
KW - Client Attitudes
KW - Organizations
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-01027-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Rudenko, Larisa
AU - Matheson, John C.
T1 - The US FDA and animal cloning: Risk and regulatory approach
JO - Theriogenology
JF - Theriogenology
Y1 - 2007/01//
VL - 67
IS - 1
M3 - Article
SP - 198
EP - 206
SN - 0093691X
AB - Abstract: The Food and Drug Administration''s (FDA''s) Center for Veterinary Medicine issued a voluntary request to producers of livestock clones not to introduce food from clones or their progeny into commerce until the agency had assessed whether production of cattle, swine, sheep, or goats by somatic cell nuclear transfer (SCNT) posed any unique risks to the animal(s) involved in the process, humans, or other animals by consuming food from those animals, compared with any other assisted reproductive technology (ART) currently in use. Following a comprehensive review, no anomalies were observed in animals produced by cloning that have not also been observed in animals produced by other ARTs and natural mating. Further systematic review on the health of, and composition of meat and milk from, cattle, swine, and goat clones and the progeny of cattle and sheep did not result in the identification of any food-consumption hazards. The agency therefore concluded that food from cattle, swine, and goat clones was as safe to eat as food from animals of those species derived by conventional means. The agency also concluded that food from the progeny of the clone of any species normally consumed for food is as safe to eat as those animals. The article also describes the methodology used by the agency to analyze data and draw these conclusions, the plans the agency has proposed to manage any identified risks, and the risk communication approaches the agency has used. [Copyright &y& Elsevier]
AB - Copyright of Theriogenology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVESTOCK
KW - CATTLE industry
KW - RISK management in business
KW - ANIMAL diseases
KW - FDA
KW - Food
KW - Livestock cloning
KW - Risk assessment
N1 - Accession Number: 23350146; Rudenko, Larisa; Email Address: larisa.rudenko@fda.hhs.gov Matheson, John C. 1; Affiliation: 1: Center for Veterinary Medicine, US Food and Drug Administration, Department of Health and Human Services, 7500 Standish Place, HFV-100, Rockville, MD 20855, USA; Source Info: Jan2007, Vol. 67 Issue 1, p198; Subject Term: LIVESTOCK; Subject Term: CATTLE industry; Subject Term: RISK management in business; Subject Term: ANIMAL diseases; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Food; Author-Supplied Keyword: Livestock cloning; Author-Supplied Keyword: Risk assessment; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.theriogenology.2006.09.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23350146&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Green, Francis H. Y.
AU - Vallyathan, Val
AU - Hahn, Fletcher F.
T1 - Comparative Pathology of Environmental Lung Disease: An Overview.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2007/01//
VL - 35
IS - 1
M3 - Article
SP - 136
EP - 147
SN - 01926233
AB - Environmental factors play a major role in a majority of lung diseases. Asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and many interstitial lung diseases are influenced or caused by environmental factors. Animals and humans may respond differently to the same agent, and a study of the comparative pathology between the two is useful for optimizing animal models of environmental lung disease and for evaluating their predictive value in carcinogenicity studies. This overview describes the most common nonneoplastic pathologic pulmonary responses to inhaled environmental agents in the human and contrasts them with the responses observed in rats exposed to the same agents. We show both similarities and difference in response to the same agents; furthermore, both species have unique responses to some agents (for example, progressive massive fibrosis in the human and proliferative squamous lesions in the rat). Quantitative analysis of the grades of response to three environmental particulate dusts revealed differences between the 2 species at the cellular level. Specifically, acute intra-alveolar inflammation, alveolar epithelial hyperplasia, and alveolar lipoproteinosis were all greater in rats than in humans exposed to the same agents. These differences may account for differences between the 2 species in carcinogenic response to nonfibrous particulates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathology
KW - Animal models in research
KW - Obstructive lung diseases
KW - Lungs -- Cancer
KW - Carcinogenesis -- Animal models
KW - comparative pathology
KW - environmental lung disease
KW - human
KW - occupational
KW - Pneumoconiosis
KW - rat
N1 - Accession Number: 24175579; Green, Francis H. Y. 1; Email Address: fgreen@ucalgary.ca; Vallyathan, Val 2; Hahn, Fletcher F. 3; Affiliations: 1: Respiratory Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada; 2: National Institute for Occupational Safety and Health, Center for Disease Control, Morgantown, WV 26505-2888, USA; 3: Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA; Issue Info: 2007, Vol. 35 Issue 1, p136; Thesaurus Term: Pathology; Thesaurus Term: Animal models in research; Subject Term: Obstructive lung diseases; Subject Term: Lungs -- Cancer; Subject Term: Carcinogenesis -- Animal models; Author-Supplied Keyword: comparative pathology; Author-Supplied Keyword: environmental lung disease; Author-Supplied Keyword: human; Author-Supplied Keyword: occupational; Author-Supplied Keyword: Pneumoconiosis; Author-Supplied Keyword: rat; Number of Pages: 12p; Illustrations: 4 Color Photographs, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/01926230601132055
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24175579&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2007-05420-002
AN - 2007-05420-002
AU - Harari, Dorith
AU - Bakermans-Kranenburg, Marian J.
AU - van IJzendoorn, Marinus J.
ED - Vermetten, Eric
ED - Dorahy, Martin
ED - Spiegel, David
ED - Vermetten, Eric, (Ed)
ED - Dorahy, Martin, (Ed)
ED - Spiegel, David, (Ed)
T1 - Attachment, disorganization, and dissociation.
T2 - Traumatic dissociation: Neurobiology and treatment.
Y1 - 2007///
SP - 31
EP - 54
CY - Arlington, VA, US
PB - American Psychiatric Publishing, Inc.
SN - 978-1-58562-196-5
N1 - Accession Number: 2007-05420-002. Partial author list: First Author & Affiliation: Harari, Dorith; University Medical Center, Altrecht Mental Health Services, Utrecht, Netherlands. Release Date: 20070604. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-1-58562-196-5, Paperback. Language: English. Major Descriptor: Attachment Behavior; Cognitive Processes; Dissociation; Dissociative Disorders. Minor Descriptor: Models; Prevention; Treatment. Classification: Psychological Disorders (3210). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24.
AB - This chapter begins with a short overview of attachment theory and the organized types of secure and insecure attachment. Next, disorganization of attachment is discussed in terms of observable behavior in children and adults and of the phenotypical resemblance of this behavior to dissociative phenomena. Concomitants and sequelae of attachment disorganization, along with its determinants, are reviewed, followed by an hypothesized model of cognitive processes associated with disorganized attachment. The model implies a causal relation between disorganized attachment and later dissociative disorders. Finally, clinical implications for the prevention of disorganized attachment and for the treatment of dissociative disorders are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attachment theory
KW - disorganization of attachment
KW - phenotypes
KW - dissociative phenomena
KW - cognitive processes
KW - models
KW - prevention
KW - treatment
KW - 2007
KW - Attachment Behavior
KW - Cognitive Processes
KW - Dissociation
KW - Dissociative Disorders
KW - Models
KW - Prevention
KW - Treatment
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-05420-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106254623
T1 - The perils of public transport.
AU - Atenstaedt RL
Y1 - 2007/01//
N1 - Accession Number: 106254623. Language: English. Entry Date: 20070323. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Continental Europe; Europe; Peer Reviewed; Public Health. NLM UID: 101230758.
KW - Communicable Diseases -- Legislation and Jurisprudence
KW - Public Health -- Legislation and Jurisprudence
KW - Transportation
KW - Communicable Diseases -- Transmission
KW - England
KW - Wales
SP - 51
EP - 52
JO - Travel Medicine & Infectious Disease
JF - Travel Medicine & Infectious Disease
JA - TRAVEL MED INFECT DIS
VL - 5
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1477-8939
AD - National Public Health Service for Wales (NPHS) and Institute of Medical & Social Care Research (IMSCaR), University of Wales Bangor, UK.
U2 - PMID: 17161321.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106254623&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2006-22427-001
AN - 2006-22427-001
AU - Kok, Gerjo
AU - Schaalma, Herman
AU - de Zwart, Onno
T1 - Editorial: AIDS 2006--Time to deliver.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 2007/01//
VL - 65
IS - 1
SP - 1
EP - 2
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
AD - Kok, Gerjo
N1 - Accession Number: 2006-22427-001. PMID: 17141110 Partial author list: First Author & Affiliation: Kok, Gerjo; Maastricht University, Department Applied and Social Psychology, Maastricht, Netherlands. Release Date: 20061218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: AIDS Prevention; Scientific Communication. Minor Descriptor: Epidemics; HIV; HIV Testing; Internet; Male Homosexuality; Mass Media; Minority Groups; Preventive Medicine; Racial and Ethnic Groups; Sexual Risk Taking; Susceptibility (Disorders); Technology. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jan, 2007.
AB - This editorial discusses major topics from a behavioral science point of view that were presented at the XVI International AIDS Conference in Toronto, Canada. The topics include: the pandemic; pre-exposure prophylaxis; gay men; advanced technology, media and Internet; ethnic groups and migrants; HIV-testing; people living with HIV and AIDS; and professionals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - XVI International AIDS Conference
KW - pandemic
KW - pre-exposure prophylaxis
KW - gay men
KW - technology
KW - media
KW - Internet
KW - ethnic groups & migrants
KW - HIV-testing
KW - living with HIV & AIDS
KW - professionals
KW - 2007
KW - AIDS Prevention
KW - Scientific Communication
KW - Epidemics
KW - HIV
KW - HIV Testing
KW - Internet
KW - Male Homosexuality
KW - Mass Media
KW - Minority Groups
KW - Preventive Medicine
KW - Racial and Ethnic Groups
KW - Sexual Risk Taking
KW - Susceptibility (Disorders)
KW - Technology
KW - 2007
DO - 10.1016/j.pec.2006.10.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22427-001&site=ehost-live&scope=site
UR - g.kok@psychology.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17826-002
AN - 2007-17826-002
AU - Kjerulff, Kristen H.
AU - Frick, Kevin D.
AU - Rhoades, Jeffrey A.
AU - Hollenbeak, Christopher S.
T1 - The cost of being a woman: A national study of health care utilization and expenditures for female-specific conditions.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2007/01//Jan-Feb, 2007
VL - 17
IS - 1
SP - 13
EP - 21
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Kjerulff, Kristen H., Penn State College of Medicine, Health Evaluation Sciences, A210, 600 Centerview Drive, P.O. Box 855, Hershey, PA, US, 17033-0855
N1 - Accession Number: 2007-17826-002. PMID: 17321943 Partial author list: First Author & Affiliation: Kjerulff, Kristen H.; Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, PA, US. Release Date: 20080303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Utilization; Human Females; Life Span. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan-Feb, 2007.
AB - Purpose: An important component of women's health care is for conditions that are exclusive to women, yet little research has addressed the economic impact of health care for these conditions. The purpose of this study was to describe health care utilization for female-specific conditions, the incremental expenditures attributable to these conditions, and the overall incremental expenditures across the lifespan. Methods: We analyzed 3 years of a nationally representative survey of the US noninstitutionalized population, the 2000-2002 National Medical Expenditure Panel Survey, which included 25,361 females aged ≥14, representing 38,170 person-years. Results: More than one fifth of women (21.2%) reported having a female-specific condition during a 1-year period, the most common of which were gynecologic disorders (7.4%); pregnancy-related conditions (6.4%); and menopausal symptoms (5.3%). The mean increment in annual total expenditures attributable to female-specific conditions ranged from $483 for menopausal disorders to $3,896 for female cancers. The annual total health care expenditures of women with female-specific conditions were estimated to be $108 billion, of which >40% ($43.3 billion) was attributable to female-specific conditions. Women with female-specific conditions who had no health insurance were less likely to have visited a doctor (p = .0002), filled a prescription (p = .001), and been hospitalized (p = .0001) for these conditions, but more likely to have visited an emergency department (p = .02) seeking treatment for these conditions. Conclusions: In this nationally representative sample of American women aged ≥14, female-specific conditions were common and substantially increased costs of health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cost
KW - woman
KW - health care utilization
KW - female-specific conditions
KW - life span
KW - 2007
KW - Health Care Costs
KW - Health Care Utilization
KW - Human Females
KW - Life Span
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: R03HS013057. Other Details: Health Care Use and Expenditures for Gynecologic Care. Recipients: No recipient indicated
DO - 10.1016/j.whi.2006.11.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17826-002&site=ehost-live&scope=site
UR - khk2@psu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02588-002
AN - 2007-02588-002
AU - Wilt, Timothy J.
AU - Niewoehner, Dennis
AU - Kane, Robert L.
AU - MacDonald, Roderick
AU - Joseph, Anne M.
T1 - Spirometry as a motivational tool to improve smoking cessation rates: A systematic review of the literature.
JF - Nicotine & Tobacco Research
JO - Nicotine & Tobacco Research
JA - Nicotine Tob Res
Y1 - 2007/01//
VL - 9
IS - 1
SP - 21
EP - 32
CY - United Kingdom
PB - Taylor & Francis
SN - 1462-2203
SN - 1469-994X
AD - Wilt, Timothy J., Minneapolis VA Center for Chronic Disease Outcomes Research, 1 Veterans Drive (111-0), Minneapolis, MN, US, 55417
N1 - Accession Number: 2007-02588-002. PMID: 17365733 Partial author list: First Author & Affiliation: Wilt, Timothy J.; Minnesota Agency for Healthcare Research and Quality Evidence-based Practice Center, Minneapolis, MN, US. Other Publishers: Oxford University Press. Release Date: 20070618. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Medical Therapeutic Devices; Smoking Cessation; Tobacco Smoking; Treatment Outcomes. Minor Descriptor: Motivation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 12. Issue Publication Date: Jan, 2007.
AB - Obtaining spirometric testing and providing those results to individuals who smoke has been advocated as a motivational tool to improve smoking cessation. However, its effectiveness is not known. We conducted a systematic review to determine if this approach improves rates of smoking cessation. Data sources included MEDLINE (1966 to October 2005), the Cochrane Library, and experts in the field. Eligible randomized controlled trials (RCTs) enrolled at least 25 smokers per arm, evaluated spirometry with associated counseling or in combination with other treatments, followed subjects at least 6 months, and provided smoking abstinence rates. Results from nonrandomized studies also were summarized. The primary outcome was patient-reported long-term (at least 6 months) sustained abstinence with biological validation. Additional outcomes included self-reported abstinence and point-prevalence abstinence. Seven RCTs (N = 6,052 subjects) met eligibility criteria. Follow-up duration ranged from 9 to 36 months. In six trials, the intervention group received concomitant treatments previously demonstrated to increase cessation independently. The range of abstinence was 3%-14% for control subjects and 7%-39% among intervention groups, statistically significantly in favor of intervention in four studies. The only RCT that assessed the independent contribution of spirometry in combination with counseling demonstrated a nonsignificant 1% improvement in patient-reported point-prevalence abstinence at 12 months in the group that received spirometry plus counseling versus counseling alone (6.5% versus 5.5%). Findings from observational studies were mixed, and the lack of controls makes interpretation problematic. Available evidence is insufficient to determine whether obtaining spirometric values and providing that information to patients improves smoking cessation compared with other smoking cessation methods. Spirometric values are of limited benefit as a predictor of smoking cessation or as a tool to 'customize' smoking cessation strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - spirometry
KW - motivational tool
KW - smoking cessation rates
KW - treatment effectiveness
KW - 2007
KW - Medical Therapeutic Devices
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Treatment Outcomes
KW - Motivation
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290-02-0009. Recipients: No recipient indicated
DO - 10.1080/14622200601078509
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02588-002&site=ehost-live&scope=site
UR - tim.wilt@med.va.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00002-004
AN - 2007-00002-004
AU - Simon, Cassandra E.
AU - Crowther, Martha
AU - Higgerson, Hyoun-Kyoung
T1 - The stage-specific role of spirituality among African American Christian women throughout the breast cancer experience.
JF - Cultural Diversity and Ethnic Minority Psychology
JO - Cultural Diversity and Ethnic Minority Psychology
JA - Cultur Divers Ethnic Minor Psychol
Y1 - 2007/01//
VL - 13
IS - 1
SP - 26
EP - 34
CY - US
PB - Educational Publishing Foundation
SN - 1099-9809
SN - 1939-0106
AD - Simon, Cassandra E., University of Alabama, School of Social Work, Box 870314, Tuscaloosa, AL, US, 35487
N1 - Accession Number: 2007-00002-004. PMID: 17227174 Other Journal Title: Cultural Diversity and Mental Health. Partial author list: First Author & Affiliation: Simon, Cassandra E.; University of Alabama, Tuscaloosa, AL, US. Other Publishers: John Wiley & Sons, Inc. Release Date: 20070116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Intercultural Cancer Council Biennial Symposium on Minorities, the Medically Underserved and Cancer Committed to Eliminating Disparities, 10th, 2006, Washington, DC, US. Conference Note: Some of these data were presented at the aforementioned conference. Major Descriptor: Breast Neoplasms; Coping Behavior; Religious Beliefs; Spirituality. Minor Descriptor: Blacks; Christianity; Christians; Disease Course. Classification: Cancer (3293). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2007. Copyright Statement: American Psychological Association. 2007.
AB - This study presents the results of semistructured interviews conducted with 18 African American Christian women regarding the role of spirituality throughout their breast cancer experiences. The spiritual themes relevant for phases of the breast cancer experience are identified. Analysis resulted in the identification of 11 codes and 5 subcodes that corresponded to the diagnosis, treatment, and posttreatment phases of the breast cancer experience. Most of the survivors indicated that their spirituality and faith assisted them throughout the breast cancer experience. Discussion focuses on the spiritual resources used by the participants at the different stages in the breast cancer experience. Attention is given to implications for how professionals can use these resources to assist African American women coping with breast cancer. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breast cancer
KW - African American women
KW - spirituality
KW - coping
KW - spirituality and health
KW - stage-specific role
KW - 2007
KW - Breast Neoplasms
KW - Coping Behavior
KW - Religious Beliefs
KW - Spirituality
KW - Blacks
KW - Christianity
KW - Christians
KW - Disease Course
KW - 2007
U1 - Sponsor: Michael Figures Initiative. Recipients: No recipient indicated
U1 - Sponsor: University of Alabama, African American Studies Department, US. Other Details: Under the directorship of Dr. Amilcar Shabazz. Recipients: No recipient indicated
DO - 10.1037/1099-9809.13.1.26
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00002-004&site=ehost-live&scope=site
UR - csimon@bama.ua.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-23126-004
AN - 2006-23126-004
AU - Tsemberis, Sam
AU - McHugo, Gregory
AU - Williams, Valerie
AU - Hanrahan, Patricia
AU - Srefancic, Ana
T1 - Measuring homelessness and residential stability: The Residential Time-Line Follow-Back Inventory.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2007/01//
VL - 35
IS - 1
SP - 29
EP - 42
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Williams, Valerie, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2006-23126-004. Partial author list: First Author & Affiliation: Tsemberis, Sam; Pathways to Housing, US. Release Date: 20070108. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Homeless; Inventories; Psychometrics; Residential Care Institutions; Test Reliability. Minor Descriptor: Home Environment; Statistical Validity. Classification: Tests & Testing (2220); Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Residential Time-Line Follow-Back Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Jan, 2007.
AB - Reliable and valid longitudinal residential histories are needed to assess interventions to reduce homelessness and increase community tenure. This study examined the test-retest reliability, sensitivity to change, and concurrent validity of the Residential Time-Line Follow-Back (TLFB) Inventory, a method used to record residential histories in the Collaborative Program to Prevent Homelessness (n = 1,381). The Residential TLFB Inventory yielded temporally stable aggregate measures of duration in residential categories, and it revealed significant differences in change over time when contrasting study groups. A comparison of agency and participant data at one site demonstrated concurrent validity. These results support the psychometric properties of the Residential TLFB Inventory and should encourage its use in both clinical and research settings as a means to assess residential outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homelessness
KW - residential stability
KW - Residential Time-Line Follow-Back Inventory
KW - test validity
KW - test reliability
KW - 2007
KW - Homeless
KW - Inventories
KW - Psychometrics
KW - Residential Care Institutions
KW - Test Reliability
KW - Home Environment
KW - Statistical Validity
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Sendees, Center for Substance Abuse Treatment. Grant: 280-94-0008. Recipients: No recipient indicated
DO - 10.1002/jcop.20132
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23126-004&site=ehost-live&scope=site
UR - Valerie.Williams@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00391-002
AN - 2007-00391-002
AU - Cardona, Robert Andrew
AU - Ritchie, Elspeth Cameron
T1 - U.S. Military Enlisted Accession Mental Health Screening: History and Current Practice.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2007/01//
VL - 172
IS - 1
SP - 31
EP - 35
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Cardona, Robert Andrew, Community Mental Health Service, Reynolds Army Community Hospital, Fort Sill, OK, US, 73503-6300
N1 - Accession Number: 2007-00391-002. PMID: 17274262 Partial author list: First Author & Affiliation: Cardona, Robert Andrew; Community Mental Health Service, Reynolds Army Community Hospital, Fort Sill, OK, US. Release Date: 20070604. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disabilities; Health Screening; Military Psychology; Psychiatric Evaluation. Minor Descriptor: Mental Health. Classification: Psychological Disorders (3210); Military Psychology (3800). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 5. Issue Publication Date: Jan, 2007.
AB - Through the stimulus of war and concerns about neuropsychiatric disability, the U.S. military developed methods to rapidly screen the mental health of World War I and II draftees. Intelligence testing and brief psychiatric screening expanded the accession physical examination and underwent revision to identify only gross mental health disability. Supplemental psychiatric evaluations and written psychological screening tools were abandoned after postwar assessments; they demonstrated poor predictive power in evaluating recruit service capacity for combat environments. Currently, only three mental health accession tools are used to screen applicants before their entrance into military service, namely, educational achievement, cognitive testing, and a cursory psychiatric evaluation. The Navy and Air Force use a fourth screening measure during entry-level training. Educational attainment with high school graduation has been the strongest predictor of finishing a service term. The purpose of this article is to provide both a historical review and a review of testing efforts. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - U.S. Military
KW - enlisted accession
KW - mental health screening
KW - neuropsychiatric disability
KW - physical examination
KW - 2007
KW - Disabilities
KW - Health Screening
KW - Military Psychology
KW - Psychiatric Evaluation
KW - Mental Health
KW - 2007
DO - 10.7205/MILMED.172.1.31
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00391-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07224-004
AN - 2007-07224-004
AU - Hamilton, Marie M.
AU - Razzano, Lisa A.
AU - Martin, Nicole B.
T1 - The relationship between type and quality of social support and HIV medication adherence.
JF - Journal of HIV/AIDS & Social Services
JO - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS Soc Serv
Y1 - 2007///
VL - 6
IS - 1-2
SP - 39
EP - 63
CY - US
PB - Haworth Press
SN - 1538-1501
AD - Hamilton, Marie M., Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL, US, 60603
N1 - Accession Number: 2007-07224-004. Partial author list: First Author & Affiliation: Hamilton, Marie M.; University of Illinois at Chicago, Center on Mental Health Services Research & Policy, Department of Psychiatry, Chicago, IL, US. Other Publishers: Taylor & Francis. Release Date: 20070730. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Health Care Services; HIV; Social Support. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Norbeck Social Support Questionnaire. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 25. Issue Publication Date: 2007.
AB - In the last 10 years HIV has become a disease that can be effectively managed using antiretroviral medications. However, many factors affect adherence, including demographics, income, housing, mental health issues, and access to health care, as well as types and quality of social support. This paper summarizes results regarding specific sources of social support that are part of a larger, randomized study of medication adherence among people with HIV/AIDS. Results summarize findings from 98 program participants and include information regarding support from partners, family and health care providers, as well as the impact of support from these sources on medication adherence. Among participants in this study, those with higher levels of social support from partners demonstrated higher rates of medication adherence. Those who received more social support from their families, however, reported significantly lower adherence rates. These results suggest that efforts to improve medication adherence need to address the diverse types of social support networks of people diagnosed with HIV/AIDS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social support
KW - HIV medication adherence
KW - antiretroviral medications
KW - health care
KW - health care providers
KW - 2007
KW - Drug Therapy
KW - Health Care Services
KW - HIV
KW - Social Support
KW - 2007
U1 - Sponsor: Field-Initiated Research Grant Program. Grant: H133G010093. Recipients: No recipient indicated
U1 - Sponsor: US Department of Education, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Disability & Rehabilitation Research. Recipients: No recipient indicated
DO - 10.1300/J187v06n01_04
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07224-004&site=ehost-live&scope=site
UR - Mhamilton@psych.uic.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08287-005
AN - 2007-08287-005
AU - Larson, Mary Jo.
AU - Miller, Kay
AU - Fleming, Kathleen J.
AU - Teich, Judith L.
T1 - Mental health services for children in large, employer-based health plans, 1999.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2007/01//
VL - 34
IS - 1
SP - 56
EP - 72
CY - Germany
PB - Springer
SN - 1094-3412
AD - Larson, Mary Jo., New England Research Institutes, Watertown, MA, US, 02472
N1 - Accession Number: 2007-08287-005. PMID: 16708290 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Larson, Mary Jo.; New England Research Institutes, Watertown, MA, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20071001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Employee Health Insurance; Health Care Costs; Health Insurance; Mental Health Services. Minor Descriptor: Hospitalization; Outpatients. Classification: Health & Mental Health Services (3370); Personnel Management & Selection & Training (3620). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jan, 2007.
AB - This study examines 1999 data from Medstat's MarketScan® database of privately insured employees of US firms and their dependents. Of enrolled children and adolescents ages 2-18, 6.6% had claims for mental health services. Average outpatient expenditures per user were $651. Of children/adolescents with claims for mental health services (MH claimants), 3.4% had inpatient MH services, with an average length of stay of 8.9 days and average MH-related inpatient expenditure per user of $7,048. One half of MH claimants who had pharmacy benefit data had claims for psychotropic medications, with average expenditures per user of $328. Whereas children/adolescent mental health users comprised 8.3% of all service users, expenditures for their care were 20.5% of all service expenditures for children/adolescents in private health plans. Results also highlight the importance of including data on psychotropic medication in analysis of children's MH services utilization, as well as the need to consider the use of psychotropic medications among children/adolescents who do not utilize other MH services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - children
KW - health plans
KW - insured employees
KW - outpatient expenditure
KW - inpatient expenditure
KW - psychotropic medications
KW - 2007
KW - Drug Therapy
KW - Employee Health Insurance
KW - Health Care Costs
KW - Health Insurance
KW - Mental Health Services
KW - Hospitalization
KW - Outpatients
KW - 2007
DO - 10.1007/s11414-006-9028-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08287-005&site=ehost-live&scope=site
UR - mjlarson@neriscience.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-03385-008
AN - 2007-03385-008
AU - Hoffman, Alexander F.
AU - Oz, Murat
AU - Yang, Ruiqin
AU - Lichtman, Aron H.
AU - Lupica, Carl R.
T1 - Opposing actions of chronic Δ⁹-tetrahydrocannabinol and cannabinoid antagonist on hippocampal long-term potentiation.
JF - Learning & Memory
JO - Learning & Memory
JA - Learn Mem
Y1 - 2007/01//Jan-Feb, 2007
VL - 14
IS - 1-2
SP - 63
EP - 74
CY - US
PB - Cold Spring Harbor Laboratory Press
SN - 1072-0502
AD - Lupica, Carl R., United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, MD, US, 21224
N1 - Accession Number: 2007-03385-008. PMID: 17202425 Partial author list: First Author & Affiliation: Hoffman, Alexander F.; United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, MD, US. Release Date: 20070618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Yang, Ruiqin. Major Descriptor: Cannabinoids; Hippocampus; Postactivation Potentials; Tetrahydrocannabinol; Long-term Potentiation. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jan-Feb, 2007.
AB - Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to Δ⁹-THC for hippocampal function are poorly understood. Rats were injected with Δ⁹-THC (10 mg/kg, i.p., q.d.) for 1, 3, or 7 d, and electrophysiological recordings were performed in hippocampal slices 1d after the final injection. At this time, Δ⁹-THC was undetectable in hippocampus using liquid chromatography-mass spectrometry (LC-MS). Hippocampal LTP generated using high-frequency (HFS) or theta burst stimulation was not observed in brain slices from the 7-d Δ⁹-THC-treated animals. Δ⁹-THC also blocked HFS-LTP after 3 d, but not 1 d of treatment. The complete blockade of LTP persisted for 3 d after the last Δ⁹-THC injection, and full reversal of the LTP deficit was not observed up to 14 d following Δ⁹-THC withdrawal. The cannabinoid antagonist AM251 (2 mg/kg), administered before each Δ⁹-THC injection prevented the blockade of LTP, and 7-d treatment with AM251 alone significantly increased the level of LTP. Chronic Δ⁹-THC also produced tolerance to the inhibition of synaptic GABA, but not glutamate release by the agonist WIN55,212-2. These data define consequences of repeated Δ⁹-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tetrahydrocannabinol
KW - cannabinoid antagonists
KW - hippocampal long-term potentiation
KW - chronic marijuana use
KW - 2007
KW - Cannabinoids
KW - Hippocampus
KW - Postactivation Potentials
KW - Tetrahydrocannabinol
KW - Long-term Potentiation
KW - 2007
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse. Other Details: Intramural Research Program. Recipients: No recipient indicated
U1 - Sponsor: USPHS. Grant: P50-DA005274; RO1-DA015683. Recipients: Yang, Ruiqin; Lichtman, Aron H.
DO - 10.1101/lm.439007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-03385-008&site=ehost-live&scope=site
UR - clupica@intra.nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-01305-001
AN - 2007-01305-001
AU - Jader, Layla
T1 - An Overview of Neurological Disorders in Wales.
JF - Neuroepidemiology
JO - Neuroepidemiology
JA - Neuroepidemiology
Y1 - 2007///
VL - 28
IS - 2
SP - 65
EP - 78
CY - Switzerland
PB - Karger
SN - 0251-5350
SN - 1423-0208
AD - Jader, Layla, Public Health Medicine, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, United Kingdom, CF10 3NW
N1 - Accession Number: 2007-01305-001. PMID: 17230026 Partial author list: First Author & Affiliation: Jader, Layla; National Public Health Service for Wales, Cardiff, United Kingdom. Release Date: 20070507. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Health Care Services; Nervous System Disorders; Neurosurgery. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Location: Wales. Methodology: Literature Review. References Available: Y. Page Count: 14. Issue Publication Date: 2007.
AB - This pragmatic work was undertaken to assist commissioners of health services in Wales in their planning for future provision of services for neurological and neurosurgical patients. A literature search, which was carried out to ascertain the epidemiology of neurological and neurosurgical disorders in Wales, revealed limited epidemiological surveys of patients in Wales, while other literatures although outdated were still relevant. More recent national reports, published by professional bodies and patients' organisations, were also identified. These disorders were also grouped according to their aetiology and symptoms into 13 groups. Using all the available literature, total estimates of annual incidence and point prevalence of these disorders were arrived at. We can conclude that approximately 5.8% of the population in Wales are affected by neurological and neurosurgical disorders that include headaches, traumatic and infectious diseases of the nervous system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurosurgical disorders
KW - Wales
KW - health services
KW - neurosurgical patients
KW - epidemiology
KW - 2007
KW - Epidemiology
KW - Health Care Services
KW - Nervous System Disorders
KW - Neurosurgery
KW - 2007
DO - 10.1159/000098549
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-01305-001&site=ehost-live&scope=site
UR - Layla.Jader@nphs.wales.nhs.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10902-011
AN - 2007-10902-011
AU - LeBourgeois, H. W. III
AU - Pinals, Debra A.
AU - Williams, Valerie
AU - Appelbaum, Paul S.
T1 - Hindsight bias among psychiatrists.
JF - Journal of the American Academy of Psychiatry and the Law
JO - Journal of the American Academy of Psychiatry and the Law
JA - J Am Acad Psychiatry Law
Y1 - 2007///
VL - 35
IS - 1
SP - 67
EP - 73
CY - US
PB - American Academy of Psychiatry & the Law
SN - 1093-6793
SN - 1943-3662
AD - LeBourgeois, H. W. III, Department of Psychiatry and Neurology, Tulane University School of Medicine, 1440 Canal Street, TB-53, 10th Floor, New Orleans, LA, US, 70112
N1 - Accession Number: 2007-10902-011. PMID: 17389347 Other Journal Title: Bulletin of the American Academy of Psychiatry & the Law. Partial author list: First Author & Affiliation: LeBourgeois, H. W. III; Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, LA, US. Release Date: 20070917. Correction Date: 20161201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Meeting of the American Academy of Psychiatry and the Law, 2004, Scottsdale, AZ, US. Conference Note: Presented at the aforementioned conference as a Research-in-Progress presentation. Major Descriptor: Forensic Psychiatry; Mental Health Services; Psychiatrists; Suicide. Minor Descriptor: Homicide; Suicidal Ideation. Classification: Health & Mental Health Services (3370); Forensic Psychology & Legal Issues (4200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: 2007.
AB - It is crucial to minimize bias when offering forensic opinions; however, to our knowledge there are few, if any, existing data examining whether psychiatrists are susceptible to one source of such bias, hindsight bias. In the current study, 235 general and forensic psychiatrists reviewed hypothetical cases in which patients with suicidal or homicidal ideation presented for psychiatric care. We informed half of the participants that a suicide or homicide had occurred shortly after the patients were released from care (hindsight group) but withheld outcome information from the other participants (control group). Participants estimated the likelihood that suicide or violence would occur at the time of the patient's release and whether the standard of care had been met in each case. Responses were compared between groups for suggestions of hindsight bias. Results indicate that hindsight bias plays a role in assessments of risk, but not of negligence, and that psychiatrists who are American Academy of Psychiatry and the Law (AAPL) members may be less prone to respond with hindsight bias than are others. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - forensic psychiatrists
KW - forensic opinions
KW - suicidal ideation
KW - psychiatric care
KW - hindsight bias
KW - 2007
KW - Forensic Psychiatry
KW - Mental Health Services
KW - Psychiatrists
KW - Suicide
KW - Homicide
KW - Suicidal Ideation
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10902-011&site=ehost-live&scope=site
UR - hlebour@tulane.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11786-008
AN - 2007-11786-008
AU - Booth-Butterfield, Steve
AU - Welbourne, Jennifer
AU - Williams, Charles
AU - Lewis, Vickie
T1 - Formative field experiments of a NIOSH alert to reduce the risks to firefighters from structural collapse: Applying the cascade framework.
JF - Health Communication
JO - Health Communication
JA - Health Commun
Y1 - 2007///
VL - 22
IS - 1
SP - 79
EP - 88
CY - United Kingdom
PB - Taylor & Francis
SN - 1041-0236
SN - 1532-7027
AD - Welbourne, Jennifer, Department of Psychology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC, US, 28223-0001
N1 - Accession Number: 2007-11786-008. PMID: 17617016 Partial author list: First Author & Affiliation: Booth-Butterfield, Steve; Department of Communication Studies, West Virginia University, Morgantown, WV, US. Other Publishers: Lawrence Erlbaum. Release Date: 20070827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Processes; Fire Fighters; Government Agencies; Occupational Safety; Persuasive Communication. Minor Descriptor: Models. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2007.
AB - The authors report two field experiments aimed at testing the impact of government safety recommendations. Using a cascade framework from the Communication Matrix (McGuire, 1985, 1989), the study tested effects of reminder cards, message format, argument quality, and mailer types on indicators of reception, processing, and response. Systematic combinations of these variables were mailed to randomly selected firefighting units in the United States. Fire chiefs were contacted by phone to complete a survey within the next month (Experiment 1, N = 2,000, 44% completion; Experiment 2, N = 600; 77% completion). Results showed highest reception rates (∼50%) with one reminder card and the standard government low-graphics format and that greater reception produced stronger intentions. Processing was stronger with the standard government low-graphics format, and processing was correlated with more positive attitudes and intentions. Response indexes were favorable (>4 on -point scale) under all conditions. Outcomes are interpreted within the framework of a communication cascade model. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - government safety recommendations
KW - firefighters
KW - structural collapse
KW - communication matrix
KW - communication reception
KW - communication response
KW - information processing
KW - NIOSH
KW - communication cascade model
KW - 2007
KW - Cognitive Processes
KW - Fire Fighters
KW - Government Agencies
KW - Occupational Safety
KW - Persuasive Communication
KW - Models
KW - 2007
DO - 10.1080/10410230701310331
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11786-008&site=ehost-live&scope=site
UR - jlwelbou@email.uncc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19986-006
AN - 2007-19986-006
AU - Teasley, Martell L.
AU - Tyson, Edgar
AU - House, Laura
T1 - Understanding leadership development in African American youth.
JF - Journal of Human Behavior in the Social Environment
JO - Journal of Human Behavior in the Social Environment
JA - J Hum Behav Soc Environ
Y1 - 2007///
VL - 15
IS - 2-3
SP - 79
EP - 98
CY - US
PB - Haworth Press
SN - 1091-1359
SN - 1540-3556
AD - Teasley, Martell L., School of Social Work, Florida State University, Tallahassee, FL, US, 32306-2750
N1 - Accession Number: 2007-19986-006. Partial author list: First Author & Affiliation: Teasley, Martell L.; School of Social Work, Florida State University, Tallahassee, FL, US. Other Publishers: Taylor & Francis. Release Date: 20080121. Correction Date: 20151214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blacks; Community Involvement; Leadership; Self-Esteem; Socioeconomic Status. Minor Descriptor: Community Services. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Hare Self-Esteem Scale DOI: 10.1037/t13334-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: 2007.
AB - This exploratory study assesses factors related to leadership development for African American adolescents participating in a community service program designed to develop young African American leaders (N = 345). Psychometric characteristics of self-reported levels of leadership are explored to determine similarities and differences between gender groups. A multivariate analysis of socioeconomic factors, levels of self-esteem, school grades, and social activities as predictors of leadership development produced mixed findings. The results suggest that higher levels of global and academic self-esteem are related to leadership characteristics in female respondents, but not males. On the other hand, the impact of program participation on leadership was only significant in the area of personal relationship skills as a form of leadership for males. Findings from this investigation point out the need for research on leadership development dynamics among African American children and adolescents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - leadership development
KW - African American youth
KW - community service program
KW - community involvement
KW - socioeconomic factors
KW - self esteem
KW - 2007
KW - Blacks
KW - Community Involvement
KW - Leadership
KW - Self-Esteem
KW - Socioeconomic Status
KW - Community Services
KW - 2007
DO - 10.1300/J137v15n02_06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19986-006&site=ehost-live&scope=site
UR - ehtyson@fordham.edu
UR - mteasley@mailer.fsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08287-007
AN - 2007-08287-007
AU - Maxfield, Myles
AU - Achman, Lori
AU - Buck, Jeffrey A.
AU - Teich, Judith L.
T1 - National estimates of mental health insurance benefits.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2007/01//
VL - 34
IS - 1
SP - 83
EP - 95
CY - Germany
PB - Springer
SN - 1094-3412
AD - Maxfield, Myles, Mathematica Policy Research. Inc., 600 Maryland Ave. S.W., Suite 550, Washington, DC, US
N1 - Accession Number: 2007-08287-007. PMID: 16688388 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Maxfield, Myles; Mathematica Policy Research. Inc., Washington, DC, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20071001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Insurance; Mental Health; Mental Health Services; Prescription Drugs. Minor Descriptor: Hospitalization; Outpatients. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jan, 2007.
AB - This article presents estimates of the proportion of the U.S. population that had mental health benefits in 1999, of the extent of their coverage, and of the proportion that were enrolled in health plans subject to the Mental Health Parity Act of 1996 (MHPA). Findings indicate that over three-quarters (76%) of the U.S. population had mental health benefits as part of their health insurance. Approximately 18% of the population had no mental health benefits, and for the remaining 6%, mental health benefits could not be determined. Of the 18% with no mental health benefits, most (84%) had no health insurance whatsoever, while the remainder (16%) had health insurance that did not cover mental health benefits. Estimates of the generosity of coverage indicate that 44% of the population had benefits that included prescription drugs, and that provided at least 30 inpatient days and 20 outpatient visits for psychiatric care. For 12% of the population, benefit generosity could not be determined. Finally, study results suggest that the MHPA affected only 42% of the U.S. population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health benefits
KW - health insurance
KW - national estimates
KW - health plans
KW - prescription drugs
KW - inpatient days
KW - outpatient visits
KW - 2007
KW - Health Insurance
KW - Mental Health
KW - Mental Health Services
KW - Prescription Drugs
KW - Hospitalization
KW - Outpatients
KW - 2007
DO - 10.1007/s11414-006-9027-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08287-007&site=ehost-live&scope=site
UR - jteich@samhsa.gov
UR - jbuck@samhsa.gov
UR - achmanl@gao.gov
UR - mmaxfield@mathematica-mpr.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02819-012
AN - 2007-02819-012
AU - Akutsu, Phillip D.
AU - Castillo, Eleanor D.
AU - Snowden, Lonnie R.
T1 - Differential referral patterns to ethnic-specific and mainstream mental health programs for four Asian American groups.
JF - American Journal of Orthopsychiatry
JO - American Journal of Orthopsychiatry
JA - Am J Orthopsychiatry
Y1 - 2007/01//
VL - 77
IS - 1
SP - 95
EP - 103
CY - US
PB - Educational Publishing Foundation
SN - 0002-9432
SN - 1939-0025
AD - Akutsu, Phillip D., Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI, US, 48109-1043
N1 - Accession Number: 2007-02819-012. PMID: 17352590 Partial author list: First Author & Affiliation: Akutsu, Phillip D.; American Culture Program and Department of Psychology, University of Michigan, Ann Arbor, MI, US. Other Publishers: American Orthopsychiatric Association, Inc.; Wiley-Blackwell Publishing Ltd. Release Date: 20070312. Correction Date: 20160331. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Asians; Mental Health Services; Professional Referral; Racial and Ethnic Differences. Minor Descriptor: Cultural Sensitivity; Client Treatment Matching. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2007. Publication History: Accepted Date: Jun 20, 2006; Revised Date: Jun 7, 2006; First Submitted Date: Mar 18, 2005. Copyright Statement: American Psychological Association. 2007.
AB - This study examined the referral patterns of Chinese, Japanese, Filipino, and Korean Americans at ethnic-specific versus mainstream programs in a public mental health system. As predicted, social/ community-based services and family/friends to a lesser degree referred each Asian American group to ethnic-specific programs more than other referral sources (e.g., criminal justice and health services). Referrals by social/community-based programs to ethnic-specific versus mainstream programs were the most significant for Chinese Americans, followed by Japanese and Filipino Americans, and the least significant for Korean Americans. These findings suggest Asian American clients themselves and their social networks may view ethnic-specific programs as more culturally responsive than mainstream programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Asian Americans
KW - professional referral
KW - mental health programs
KW - community-based organizations
KW - 2007
KW - Asians
KW - Mental Health Services
KW - Professional Referral
KW - Racial and Ethnic Differences
KW - Cultural Sensitivity
KW - Client Treatment Matching
KW - 2007
DO - 10.1037/0002-9432.77.1.95
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02819-012&site=ehost-live&scope=site
UR - akutsu@umich.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07331-012
AN - 2007-07331-012
AU - Zuvekas, Samuel H.
AU - Rupp, Agnes
AU - Norquist, Grayson
T1 - Cost shifting under managed behavioral health care.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/01//
VL - 58
IS - 1
SP - 100
EP - 108
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Zuvekas, Samuel H., Center for Financing Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD, US, 20850
N1 - Accession Number: 2007-07331-012. PMID: 17215419 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Center for Financing Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20070924. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Health Care Costs; Managed Care; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2007.
AB - Objective: The study examined whether a managed behavioral health care organization (MBHO) shifted treatment costs. Methods: Four years of claims data (1991-1995) from an insurer that introduced an MBHO in 1992 to control treatment costs were analyzed. Although the MBHO was not at direct financial risk for specialty mental health treatment, it faced incentives related to reputation and contract renewal to shift costs to primary care treatment or prescription drugs. It was hypothesized that if cost shifting occurred, an increase would be noted in the use of psychotropic medications without concurrent use of specialty mental health treatment. Simple t tests and a generalized estimating equations probit specification were used to test this hypothesis. Separate tests were performed for use of any psychotropic medication, any newer antidepressant, and any stimulant in a large employer group that simultaneously implemented parity coverage (75,360 enrollees) and a group of smaller employers that did not (9,228 enrollees). Results: The use of any psychotropic medication rose 64% in relative terms (p < .001) over the four-year period among enrollees of the large employer group and by 87% in the smaller groups (p < .001). In general, there were downward secular trends in the use of psychotropic medications without specialty care. Introduction of the MBHO was not significantly associated with the use of psychotropic medication alone. For newer antidepressants, introduction of the MBHO was associated in the large group with a 2.4 (p = .003) absolute percentage point decrease in medication use alone. Conclusions: No evidence was found to suggest that the MBHO shifted treatment costs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cost shifting
KW - managed behavioral health care
KW - 2007
KW - Costs and Cost Analysis
KW - Health Care Costs
KW - Managed Care
KW - Mental Health Services
KW - 2007
DO - 10.1176/appi.ps.58.1.100
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07331-012&site=ehost-live&scope=site
UR - szuvekas@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-04256-007
AN - 2007-04256-007
AU - Galvin, Deborah M.
AU - Miller, Ted R.
AU - Spicer, Rebecca S.
AU - Waehrer, Geetha M.
T1 - Substance abuse and the uninsured worker in the United States.
JF - Journal of Public Health Policy
JO - Journal of Public Health Policy
JA - J Public Health Policy
Y1 - 2007///
VL - 28
IS - 1
SP - 102
EP - 117
CY - United Kingdom
PB - Palgrave Macmillan
SN - 0197-5897
SN - 1745-655X
AD - Miller, Ted R., Pacific Institute for Research and Evaluation, 11710 Beltsville Drive, Suite 125, Calverton, MD, US, 20705
N1 - Accession Number: 2007-04256-007. PMID: 17363941 Partial author list: First Author & Affiliation: Galvin, Deborah M.; Center for Substance Abuse Prevention, Rockville, MD, US. Release Date: 20070820. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Epidemiology; Health Insurance; Uninsured (Health Insurance). Minor Descriptor: Employee Assistance Programs. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: 2007.
AB - Although millions of US workers lack health insurance, the relationship of insurance coverage with substance abuse and access to workplace treatment services remains unexplored. Our analysis shows uninsured workers have higher rates of heavy drinking and illicit drug use than insured workers. Young and part-time workers are, moreover, less likely to have insurance coverage than workers with lower substance abuse risks. Compared to the insured, uninsured workers have less access to employee assistance programs (EAPs) and less drug and alcohol testing by employers. The effectiveness of workplace substance abuse programs and policies designed for insured populations is untested among uninsured workers. Issues include EAP effectiveness with referrals to public treatment and the return on investment for adding coverage of substance abuse treatment. Workers in countries with universal health insurance but inadequate treatment capacity may face similar problems to uninsured workers in the US. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - uninsured workers
KW - substance abuse
KW - health coverage
KW - employee assistance programs
KW - 2007
KW - Drug Abuse
KW - Epidemiology
KW - Health Insurance
KW - Uninsured (Health Insurance)
KW - Employee Assistance Programs
KW - 2007
U1 - Sponsor: Center for Substance Abuse Prevention. Grant: 277-00-6103. Recipients: No recipient indicated
DO - 10.1057/palgrave.jphp.3200105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-04256-007&site=ehost-live&scope=site
UR - waehrer@pire.org
UR - spicer@pire.org
UR - Miller@pire.org
UR - Deborah.Galvin@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-00743-014
AN - 2007-00743-014
AU - Lopez, Victor A.
AU - Detera-Wadleigh, Sevilla
AU - Cardona, Imer
AU - Kassem, Layla
AU - McMahon, Francis J.
T1 - Nested Association Between Genetic Variation in Tryptophan Hydroxylase II, Bipolar Affective Disorder, and Suicide Attempts.
JF - Biological Psychiatry
JO - Biological Psychiatry
JA - Biol Psychiatry
Y1 - 2007/01//
VL - 61
IS - 2
SP - 181
EP - 186
CY - Netherlands
PB - Elsevier Science
SN - 0006-3223
AD - Lopez, Victor A., National Institutes of Health, National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders Mood and Anxiety Program, US Department of Health and Human Services, 35 Convent Drive, Room 1A-202, Bethesda, MD, US
N1 - Accession Number: 2007-00743-014. PMID: 16806105 Partial author list: First Author & Affiliation: Lopez, Victor A.; National Institutes of Health, National Institute of Mental Health, Genetic Basis of Mood and Anxiety Disorders Mood and Anxiety Program, US Department of Health and Human Services, Bethesda, MD, US. Institutional Authors: The National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Release Date: 20070129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Lopez, Victor A. Major Descriptor: Attempted Suicide; Bipolar Disorder; Genetics; Polymorphism; Tryptophan. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Diagnostic Interview for Genetic Studies; Family Interview for Genetic Studies. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jan, 2007.
AB - Background: Bipolar affective disorder (BPAD) is a common mental illness that is strongly associated with suicide. Suicidal behavior is thought to result from an interaction of genetic, neurobiological, and psychosocial factors and tends to cluster in families, suggesting specific familial factors distinct from those that underlie BPAD itself. Serotonin signaling has long been implicated in both BPAD and suicide, and the gene encoding the brain-expressed isoform of tryptophan hydroxlyase (TPH2) has been described. Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent. No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample. Methods: The sample consisted of 2018 members of 670 families, ascertained through a sibling pair affected with bipolar I, bipolar II, or schizoaffective-bipolar disorder and diagnosed under DSM-III/IV criteria. Three single nucleotide polymorphisms representing the common haplotypes spanning TPH2 were analyzed. Results: Single-marker analysis failed to detect significant genetic association with BPAD or SA, but the number of informative families was small. Haplotype analysis showed significant association with both BPAD and SA, and the same haplotype was significantly associated with both BPAD and SA in a replication sample. Case-only analysis, stratified by SA, suggested that TPH2 was not an independent genetic risk factor for SA in this sample. Conclusions: The TPH2 might contribute to the risk of both BPAD and SA in families with BPAD. Further studies are needed to uncover the functional genetic variation that accounts for the observed associations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tryptophan hydroxylase II
KW - TPH2
KW - attempted suicide
KW - bipolar disorder
KW - genetic variation
KW - polymorphism
KW - 2007
KW - Attempted Suicide
KW - Bipolar Disorder
KW - Genetics
KW - Polymorphism
KW - Tryptophan
KW - 2007
U1 - Sponsor: National Institute of Mental Health. Other Details: Intramural Research Program. Recipients: No recipient indicated
U1 - Sponsor: Pan American Health Organization, US. Other Details: fellowship awarded. Recipients: Lopez, Victor A.
DO - 10.1016/j.biopsych.2006.03.028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-00743-014&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - victorlopez1@gmail.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-20801-023
AN - 2006-20801-023
AU - Coben, Jeffrey H.
AU - Steiner, Claudia A.
AU - Miller, Ted R.
T1 - Characteristics of motorcycle-related hospitalizations: Comparing states with different helmet laws.
JF - Accident Analysis and Prevention
JO - Accident Analysis and Prevention
JA - Accid Anal Prev
Y1 - 2007/01//
VL - 39
IS - 1
SP - 190
EP - 196
CY - Netherlands
PB - Elsevier Science
SN - 0001-4575
AD - Coben, Jeffrey H., Department of Emergency Medicine, Injury Control Research Center, West Virginia University, P.O. Box 9151, Morgantown, WV, US, 26506-9151
N1 - Accession Number: 2006-20801-023. PMID: 16920053 Partial author list: First Author & Affiliation: Coben, Jeffrey H.; Department of Emergency Medicine, Injury Control Research Center, West Virginia University, Morgantown, WV, US. Release Date: 20061127. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Highway Safety; Hospitalization; Laws; Motor Traffic Accidents. Classification: Transportation (4090); Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2007.
AB - This study compares U.S. motorcycle-related hospitalizations across states with differing helmet laws. Cross-sectional analyses of hospital discharge data from 33 states participating in the Healthcare Cost and Utilization Project in 2001 were conducted. Results revealed that motorcyclists hospitalized from states without universal helmet laws are more likely to die during the hospitalization, sustain severe traumatic brain injury, be discharged to long-term care facilities, and lack private health insurance. This study further illustrates and substantiates the increased burden of hospitalization and long-term care seen in states that lack universal motorcycle helmet use laws. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospitalizations
KW - helmet laws
KW - motorcycle accidents
KW - highway safety
KW - 2007
KW - Highway Safety
KW - Hospitalization
KW - Laws
KW - Motor Traffic Accidents
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1016/j.aap.2006.06.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-20801-023&site=ehost-live&scope=site
UR - jcoben@hsc.wvu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-02126-014
AN - 2008-02126-014
AU - Salina, Doreen D.
AU - Lesondak, Linda M.
AU - Razzano, Lisa A.
AU - Weilbaecher, Ann
T1 - Co-occurring mental disorders among incarcerated women: Preliminary findings from an integrated health treatment study.
JF - Journal of Offender Rehabilitation
JO - Journal of Offender Rehabilitation
JA - J Offender Rehabil
Y1 - 2007///
VL - 45
IS - 1-2
SP - 207
EP - 225
CY - US
PB - Haworth Press
SN - 1050-9674
SN - 1540-8558
AD - Salina, Doreen D., Northwestern University, Feinberg School of Medicine, 333 N. Michigan Ave., Suite 1801, Chicago, IL, US, 60601
N1 - Accession Number: 2008-02126-014. Other Journal Title: Journal of Offender Counseling, Services & Rehabilitation. Partial author list: First Author & Affiliation: Salina, Doreen D.; Northwestern University, Feinberg School of Medicine, Chicago, IL, US. Other Publishers: Taylor & Francis. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Criminal Justice; Health Care Services; Human Females; Mental Disorders. Minor Descriptor: Criminal Behavior; Diagnosis; Incarceration; Posttraumatic Stress Disorder. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Female (40). Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Global Assessment of Functioning Scale; Structured Clinical Interview for DSM-IV. Methodology: Empirical Study; Quantitative Study. Page Count: 19. Issue Publication Date: 2007.
AB - There is a growing awareness of the incidence of mental disorders among women involved in the criminal justice system. Two hundred and eighty-three women were participants in a federally-funded study and all met DSM-IV criteria for at least two Axis I disorders, including one substance abuse diagnosis. Posttraumatic Stress Disorder (chronic) was the primary mental health diagnosis for 75% of the sample. Based on findings, the need for rigorous and accurate diagnostic evaluation for women in criminal justice settings is discussed; specific recommendations include: providing evidence-based, integrated, trauma-informed treatment, and designing comprehensive gender-specific programs to improve outcomes for incarcerated women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - co-occurring mental disorders
KW - incarcerated women
KW - integrated health treatment
KW - criminal justice
KW - posttraumatic stress disorder
KW - diagnosis
KW - 2007
KW - Comorbidity
KW - Criminal Justice
KW - Health Care Services
KW - Human Females
KW - Mental Disorders
KW - Criminal Behavior
KW - Diagnosis
KW - Incarceration
KW - Posttraumatic Stress Disorder
KW - 2007
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse, US. Grant: R21 DA019247-01. Other Details: Integrated health treatment for women drug users. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse, US. Grant: R21-DA019247. Recipients: No recipient indicated
DO - 10.1300/J076v45n01_14
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-02126-014&site=ehost-live&scope=site
UR - annweill@sbcglobal.net
UR - Razzano@psych.uic.edu
UR - Lesondak_Linda@cdph.org
UR - d.salina@horthwestern.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19643-006
AN - 2009-19643-006
AU - Selwyn, Neil
AU - Powell, Eryl
T1 - Sex and relationships education in schools: The views and experiences of young people.
JF - Health Education
JO - Health Education
JA - Health Educ (Lond)
Y1 - 2007///
VL - 107
IS - 2
SP - 219
EP - 231
CY - United Kingdom
PB - Emerald Group Publishing Limited
SN - 0965-4283
SN - 1758-714X
AD - Selwyn, Neil
N1 - Accession Number: 2009-19643-006. Partial author list: First Author & Affiliation: Selwyn, Neil; Cardiff School of Social Sciences, Cardiff, United Kingdom. Release Date: 20100607. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Schools; Sex Education; Student Attitudes; Interpersonal Relationships. Minor Descriptor: Health Education. Classification: Curriculum & Programs & Teaching Methods (3530). Population: Human (10); Male (30); Female (40). Location: United Kingdom. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: 2007. Copyright Statement: Emerald Group Publishing Limited
AB - Purpose: The purpose of the paper is to investigate how young people are using school-based sources of sex and relationships education (SRE) to obtain information and advice. Design/methodology/approach: The paper shows how anonymous self-completion questionnaires were administered to young people aged between 12 and 19 years in three secondary school and six out-of-school youth settings (n = 401). Follow-up focus group interviews were conducted with 12 groups of young people from the school and out-of-school settings (n = 57). Findings: The paper finds that school lessons were the most frequent source of sex and relationships information for many young people. Lessons were reported to be most useful for students who were male, younger and more educationally engaged. School lessons were widely criticised by young people as predominantly focusing on biological aspects of sex and relationships and lacking a discursive or participatory element. Young people perceived a diminishing commitment to SRE by teachers as they progressed into later years. Research limitations/implications: The paper examines a predominantly working-class sample of young people from one urban area of South Wales. Practical implications/implications: On the basis of the data analysis in this paper a number of suggestions are made regarding the nature of future school provision of SRE. Originality/value: This paper raises awareness and highlights issues surrounding the role of schools, teachers and school nurses in sex and relationships education. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex education
KW - relationships education
KW - school based sources
KW - student attitudes
KW - 2007
KW - Schools
KW - Sex Education
KW - Student Attitudes
KW - Interpersonal Relationships
KW - Health Education
KW - 2007
U1 - Sponsor: Cardiff Children and Young People’s Partnership. Grant: CYM267. Other Details: Research grant. Recipients: No recipient indicated
DO - 10.1108/09654280710731575
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19643-006&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0001-9489-2692
UR - selwynnc@cardiff.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-22472-028
AN - 2006-22472-028
AU - Wu, Li-Tzy
AU - Schlenger, William E.
AU - Galvin, Deborah M.
T1 - 'Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths': Corrigendum.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2007/01//
VL - 86
IS - 2-3
SP - 301
EP - 301
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Wu, Li-Tzy, Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, P.O. Box 17969, Durham, NC, US, 27715
N1 - Accession Number: 2006-22472-028. Partial author list: First Author & Affiliation: Wu, Li-Tzy; Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, DUMC, Durham, NC, US. Release Date: 20061218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Demographic Characteristics; Flunitrazepam; Ketamine; Lysergic Acid Diethylamide; Methamphetamine. Minor Descriptor: Drug Usage; Methylenedioxymethamphetamine. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Page Count: 1. Issue Publication Date: Jan, 2007.
AB - Reports an error in 'Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths' by Li-Tzy Wu, William E. Schlenger and Deborah M. Galvin (Drug and Alcohol Dependence, 2006[Sep], Vol 84[1], 102-113). The authors wish to make the following statement regarding their paper: In this paper, we reported on the prevalence of use of 'club drugs' by young Americans aged 16-23, based on secondary analyses of data from the National Survey on Drug Use and Health (NSDUH). Unfortunately, we failed to alert readers to methodological differences in NSDUH's approach to assessment of use among the six drugs we studied that may result in underestimates of the prevalence of use of two of them. Use of methamphetamine, MDMA, LSD, and flunitrazepam (Rohypnol) is assessed directly (e.g., 'Have you ever, even once, used LSD, also called 'acid'?'), but the use of GHB and ketamine is assessed indirectly. The indirect approach to assessment of GHB and ketamine use may result in underestimates of the prevalence of use of these two drugs. Detailed descriptions of the methods for assessment of use of drugs in NSDUH can be found in (http://www.oas.samhsa.gov/nhsda/methods.cfm#2k2), and readers of our paper are cautioned to interpret carefully the findings related to GHB and ketamine in light of the assessment differences. (The following abstract of the original article appeared in record [rid]2006-10304-011[/rid].) Background: The magnitude and the characteristics of the use of methamphetamine, MDMA (Ecstasy), LSD (D-lysergic acid diethylamide), ketamine, GHB (gamma-hydroxybutyrate), and flunitrazepam (Rohypnol) were examined in a probability sample of the U.S. civilian population that included multiethnic urban, suburban, and rural youths aged 16-23 (N=19,084). Methods: Data were drawn from the National Survey on Drug Use and Health (NSDUH). Logistic regression analyses were conducted to identify the characteristics associated with the use of each of these drugs and of multiple drugs. Results: Approximately 20% of youths aged 16-23 reported having ever used one or more of these drugs. Less than 1% of club drug users used club drugs only, and 82% of them had ever used three or more drug classes. Females were more likely than males to report using multiple club drugs. Recent users of methamphetamine were most likely to be females and adolescents aged 16 or 17. Recent users of MDMA tended to be young adults aged 18-21 and residents of metropolitan areas. Most recent users of LSD were adolescents aged 16-19 and those in low-income families. Ketamine users were primarily employed youths. Staying in school and getting married were associated with decreased odds of club drug use. Club drug use was highly associated with the presence of criminal behaviors and recent alcohol abuse or dependence. Conclusions: Adolescents are more likely than young adults to use multiple drugs. The clustering of multidrug use and alcohol use disorder is a cause of concern. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - magnitude
KW - characteristics
KW - use
KW - methamphetamine
KW - D-lysergic acid diethylamide
KW - ketamine
KW - gamma-hydroxybutyrate
KW - flunitrazepam
KW - Ecstasy
KW - 2007
KW - Demographic Characteristics
KW - Flunitrazepam
KW - Ketamine
KW - Lysergic Acid Diethylamide
KW - Methamphetamine
KW - Drug Usage
KW - Methylenedioxymethamphetamine
KW - 2007
DO - 10.1016/j.drugalcdep.2006.01.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-22472-028&site=ehost-live&scope=site
UR - litzywu@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12097-010
AN - 2007-12097-010
AU - Brinker, Allen
AU - Mosholder, Andrew
AU - Schech, Stephanie D.
AU - Burgess, Margaret
AU - Avigan, Mark
T1 - Indication and use of drug products used to treat attention-deficit/hyperactivity disorder: A cross-sectional study with inference on the likelihood of treatment in adulthood.
JF - Journal of Child and Adolescent Psychopharmacology
JO - Journal of Child and Adolescent Psychopharmacology
JA - J Child Adolesc Psychopharmacol
Y1 - 2007///
VL - 17
IS - 3
SP - 328
EP - 333
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1044-5463
SN - 1557-8992
AD - Brinker, Allen, FDA, White Oak Campus, Room 3412, Building 22, 10903 New Hampshire Avenue, Silver Spring, MD, US, 20993
N1 - Accession Number: 2007-12097-010. PMID: 17630866 Partial author list: First Author & Affiliation: Brinker, Allen; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, US. Release Date: 20071105. Correction Date: 20110620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Attention Deficit Disorder with Hyperactivity; Drug Therapy. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: 2007.
AB - Introduction: Published literature suggests that attention-deficit/hyperactivity disorder (ADHD) affects 4% of adults and that as many as 60% of children with a diagnosis of ADHD will continue to have problems with inattention and impulsivity in adulthood. We analyzed cross-sectional prescription claims data and data from a national survey of office-based physicians for further inference on the likelihood of treatment with ADHD medications into adulthood. Methods: This study used data from a proprietary, national survey of office-based physicians (the IMS Health National Disease and Therapeutic Index, NDTI™) to describe the indication associated with office visits with mention of common stimulant medications and atomoxetine. Enrollment and prescription claims data maintained by a large national health-care company were analyzed for age-specific utilization of these same agents. Results: Data from the NDTI™ suggest that the vast majority of visits associated with a stimulant medication or atomoxetine was coded with a diagnosis consistent with a mental health condition and not obesity/weight loss. The health plans included in this study processed 222,096 prescriptions for stimulant medications and atomoxetine among 43,175 unique patients aged 1-64 years during the calendar year 2004. Analyses of pharmacy claims data showed a steep increase in use through age 11 (prevalence = 70.3 per 1,000 covered lives) followed by a marked decrease and plateau from age 25 through age 64 years (prevalence = 5 to 10 per 1,000 covered lives). Conclusions: On the basis of comparison of the prevalence rate peak of 70 per 1,000 around age 11 years to a plateau of 7 per 1,000 during the early career years, our results are consistent with a prediction that at least one child in 10 placed on an ADHD medication in childhood will receive treatment in to adulthood. The decrease in the prevalence of use of these medications with advancing age as seen in this cross-sectional study may reflect upon several clinical and secular factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attention-deficit disorder with hyperactivity
KW - treatment
KW - age differences
KW - 2007
KW - Age Differences
KW - Attention Deficit Disorder with Hyperactivity
KW - Drug Therapy
KW - 2007
U1 - Sponsor: US Food and Drug Administration, US. Grant: FD-U-002067-02; FD-U-002067-03. Recipients: No recipient indicated
DO - 10.1089/cap.2006.0062
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12097-010&site=ehost-live&scope=site
UR - allen.brinker@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18087-006
AN - 2007-18087-006
AU - Coleman, Patrick J.
AU - Kerkering, John C.
T1 - Measuring mining safety with injury statistics: Lost workdays as indicators of risk.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2007///
VL - 38
IS - 5
SP - 523
EP - 533
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
N1 - Accession Number: 2007-18087-006. PMID: 18023637 Partial author list: First Author & Affiliation: Coleman, Patrick J.; National Institute for Occupational Safety and Health, Spokane Research Laboratory, US. Release Date: 20071210. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Measurement; Risk Factors; Safety; Statistics. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: 2007.
AB - Problem: Mining in the United States remains one of the most hazardous industries, despite significant reductions in fatal injury rates over the last century. Coal mine fatality rates, for example, have dropped almost a thousand-fold since their peak in 1908. While incidence rates are very important indicators, lost worktime measures offer an alternative metric for evaluating job safety and health performance. The first objective of this study examined the distributions and summary statistics of all injuries reported to the Mine Safety and Health Administration from 1983 through 2004. Over the period studied (1983-2004), there were 31,515,368 lost workdays associated with mining injuries, for an equivalent of 5,700 person-years lost annually. The second objective addressed the problem of comparing safety program performance in mines for situations where denominator data were lacking. By examining the consequences of injuries, comparisons can be made between disparate operations without the need for denominators. Total risk in the form of lost workday sums can help to distinguish between lower- and higher-risk operations or time periods. Method: Our method was to use a beta distribution to model the losses and to compare underground coal mining to underground metal/nonmetal mining from 2000 to 2004. Results: Our results showed the probability of an injury having 10 or more lost workdays was 0.52 for coal mine cases versus 0.35 for metal/nonmetal mine cases. In addition, a comparison of injuries involving continuous mining machines over 2001-2002 versus 2003-2004 showed that the ratio of average losses in the later period to those in the earlier period was approximately 1.08, suggesting increasing risks for such operations. Discussion: This denominator-free safety measure will help the mining industry more effectively identify higher-risk operations and more realistically evaluate their safety improvement programs. Impact on Industry: Attention to a variety ofmetrics concerning the performance of a job safety and health programwill enhance industry's ability to manage these programs and reduce risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mining safety
KW - injury statistics
KW - lost workdays
KW - risk
KW - 2007
KW - Injuries
KW - Measurement
KW - Risk Factors
KW - Safety
KW - Statistics
KW - 2007
DO - 10.1016/j.jsr.2007.06.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18087-006&site=ehost-live&scope=site
UR - pjc1@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18765-002
AN - 2007-18765-002
AU - Pan, Christopher S.
AU - Hoskin, Alan
AU - McCann, Michael
AU - Lin, Mei-Li
AU - Fearn, Kevin
AU - Keane, Paul
T1 - Aerial lift fall injuries: A surveillance and evaluation approach for targeting prevention activities.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2007///
VL - 38
IS - 6
SP - 617
EP - 625
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Pan, Christopher S., National Institute for Occupational Safety and Health, Morgantown, WV, US, Alan, 26505
N1 - Accession Number: 2007-18765-002. PMID: 18054593 Partial author list: First Author & Affiliation: Pan, Christopher S.; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20071217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Falls; Industrial Accidents; Injuries; Occupational Safety. Minor Descriptor: Hazards; Monitoring; Observation Methods; Trends; Work Related Illnesses. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: 2007.
AB - Problem: Work on aerial lift platforms exposes workers to fall hazards. The objective of this study was to identify the most common injury scenarios and determine current research gaps for addressing fall incidents associated with aerial lifts. Methods: Three databases were searched: Census of Fatal Occupational Injuries (CFOI), NIOSH Fatality Assessment and Control Evaluation (FACE) reports, and OSHA Incident Investigation Records. Results: The majority of falls/collapses/tipovers were within the height-category of 10-29 feet. Tipovers comprised 44-46% of boom-lift falls and 56-59% of scissor-lift falls. Constructing and repairing activities were most commonly associated with fall/collapse/tipover incidents. Discussion: CFOI and OSHA/FACE show convergent data, suggesting similar scenarios for aerial lift tipovers. Impact on Industry: The analysis provides the aerial lift industry information to prioritize their efforts on aerial lift design. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - aerial lift fall incidents
KW - injuries
KW - equipment failure
KW - safety
KW - surveillance
KW - evaluation approach
KW - prevention
KW - 2007
KW - Accident Prevention
KW - Falls
KW - Industrial Accidents
KW - Injuries
KW - Occupational Safety
KW - Hazards
KW - Monitoring
KW - Observation Methods
KW - Trends
KW - Work Related Illnesses
KW - 2007
DO - 10.1016/j.jsr.2007.08.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18765-002&site=ehost-live&scope=site
UR - cpan@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19927-002
AN - 2007-19927-002
AU - Wright, Douglas A.
AU - Bobashev, Georgiy
AU - Folsom, Ralph
T1 - Understanding the relative influence of neighborhood, family, and youth and adolescent drug use.
JF - Substance Use & Misuse
JO - Substance Use & Misuse
JA - Subst Use Misuse
Y1 - 2007///
VL - 42
IS - 14
SP - 2159
EP - 2171
CY - US
PB - Informa Healthcare
SN - 1082-6084
SN - 1532-2491
AD - Wright, Douglas A., Substance Abuse and Mental Health Services Administration, Office of Applied Studies, Room 7-1019 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2007-19927-002. PMID: 18097997 Other Journal Title: International Journal of the Addictions. Partial author list: First Author & Affiliation: Wright, Douglas A.; Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, US. Other Publishers: Taylor & Francis. Release Date: 20080211. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Family; Marijuana Usage; Neighborhoods; Protective Factors; Risk Factors. Minor Descriptor: Social Influences. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: 2007.
AB - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing 'components of variance' in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative 'importance.' We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent drug use
KW - protective factors
KW - households
KW - individual & family & neighborhood influences
KW - marijuana use
KW - risk factors
KW - 2007
KW - Family
KW - Marijuana Usage
KW - Neighborhoods
KW - Protective Factors
KW - Risk Factors
KW - Social Influences
KW - 2007
DO - 10.1080/10826080701212675
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19927-002&site=ehost-live&scope=site
UR - Douglas.Wright@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2006-23305-000
AN - 2006-23305-000
AU - Fisher, William H.
ED - Fisher, William H.
T1 - Research on community-based mental health services for children and adolescents.
T3 - Research in community and mental health; Vol 14; ISSN: 0192-0812 (Print)
Y1 - 2007///
VL - 14
CY - US
PB - Elsevier Science/JAI Press
SN - 0192-0812
SN - 0-7623-1315-3
SN - 978-0-7623-1315-0
N1 - Accession Number: 2006-23305-000. Partial author list: First Author & Affiliation: Fisher, William H.; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080414. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 0-7623-1315-3, Hardcover; 978-0-7623-1315-0, Hardcover. Language: English. Major Descriptor: Community Mental Health Services; Health Care Delivery; Mental Health Services; Health Care Policy. Classification: Community & Social Services (3373). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Page Count: 237.
AB - Research on mental health services for children and adolescents has become a vibrant subspecialty within the larger field of mental health services research. This research program experienced a somewhat later start than that focusing on adults, and faces a set of issues and challenges that are both different and in many ways more complex. The served population itself is bounded by infancy and the late teen years, and includes all age groups in between. This developmental spectrum naturally necessitates there being a correspondingly diverse array of mental health services. The disorders experienced by children and adolescents can become apparent in the family, the school, the pediatrician's office, the social welfare agency or the courts, and the settings in which services may be provided can include any or all of these, as well as numerous others. Indeed, it has become standard practice in discussing mental health service delivery for this population to emphasize 'systems of care,' although identifying the outlines and boundaries of such systems can itself be a daunting task. These and myriad other factors serve to differentiate the nature of mental health services for children and adolescents from those for adults. Nonetheless, both systems operate within a contemporary mental health policy framework mandating that services be both 'evidence based' and integrated with one another. The chapters in this volume singly and collectively reflect the richness and complexity of research in this burgeoning and vitally important area and also highlight the novel conceptual and methodological approaches researchers in this field are taking in tackling its most critical issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - community-based services
KW - children
KW - adolescents
KW - mental health policy
KW - 2007
KW - Community Mental Health Services
KW - Health Care Delivery
KW - Mental Health Services
KW - Health Care Policy
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-23305-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2007-12124-000
AN - 2007-12124-000
AU - Henningfield, Jack E.
AU - Santora, Patricia B.
AU - Bickel, Warren K.
ED - Henningfield, Jack E.
ED - Santora, Patricia B.
ED - Bickel, Warren K.
T1 - Addiction treatment: Science and policy for the twenty-first century.
Y1 - 2007///
CY - Baltimore, MD, US
PB - Johns Hopkins University Press
SN - 0-8018-8669-4
SN - 978-0-8018-8669-0
N1 - Accession Number: 2007-12124-000. Partial author list: First Author & Affiliation: Henningfield, Jack E.; Johns Hopkins School of Medicine, Baltimore, MD, US. Release Date: 20080324. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 0-8018-8669-4, Hardcover; 978-0-8018-8669-0, Hardcover. Language: English. Major Descriptor: Drug Addiction; Health Care Services; Policy Making; Sciences; Treatment. Minor Descriptor: Social Issues; Theories. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 221.
AB - This innovative book critically examines drug addiction treatment in the United States. It explores specific challenges (scientific, medical, social, and legal) to reaching the goal that treatment for drug addiction should be as accessible as treatments for diseases of the heart, liver, and lungs which often result from the use of addictive drugs. The book consists of three parts. Part I examines the emerging science and theories that underlie the development of specific models for treating addiction to illicit opioids and stimulants, alcohol, tobacco, and prescription drugs. Part II explores the complications raised by the diversity of those with addictions, ranging from pregnant women who use intravenous drugs, young men who abuse methamphetamines, youths who smoke cigarettes, and adults who abuse alcohol to those who smoke marijuana or abuse prescription drugs. Part III provides a detailed analysis of health care, social, and policy issues that challenge our views about addiction and its treatment. It addresses controversial topics such as whether addiction should be considered a disease or a behavior, whether addiction should be handled as a criminal offense or treated as a public health problem, and whether stigmatizing addiction is helpful or not. Throughout the book, compelling examples of addiction art explore the human side of addiction through the lens of visual artists' stunning insights into addiction and recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug addiction
KW - treatment
KW - emerging science
KW - theories
KW - health care issues
KW - social issues
KW - policy issues
KW - 2007
KW - Drug Addiction
KW - Health Care Services
KW - Policy Making
KW - Sciences
KW - Treatment
KW - Social Issues
KW - Theories
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12124-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CONF
ID - 2008-01103-000
AN - 2008-01103-000
AU - Slikker, William Jr.
AU - Andrews, Russell J.
AU - Trembly, Bruce
ED - Slikker, William Jr.
ED - Andrews, Russell J.
ED - Trembly, Bruce
T1 - Neuroprotective agents: Eighth International Neuroprotection Society meeting.
T3 - Annals of the New York Academy of Sciences; Vol 1122; ISSN: 0077-8923 (Print)
Y1 - 2007///
VL - 1122
CY - Malden; New York, NY, US
PB - Blackwell Publishing
PB - New York Academy of Sciences
SN - 0077-8923
SN - 1-57331-685-7
SN - 978-1-57331-685-9
N1 - Accession Number: 2008-01103-000. Partial author list: First Author & Affiliation: Slikker, William Jr.; FDA, National Center for Toxicological Research, US. Release Date: 20080407. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Conference Proceedings. ISBN: 1-57331-685-7, Paperback; 978-1-57331-685-9, Paperback. Language: English. Major Descriptor: Nervous System; Neurosciences; Pathophysiology; Protective Factors; Nanotechnology. Minor Descriptor: Neuroprotection. Classification: Physiological Psychology & Neuroscience (2500). Intended Audience: Psychology: Professional & Research (PS). Page Count: 331.
AB - This volume contains reports presented at the Eighth International Conference on Neuroprotective Agents held on Mackinac Island, Michigan, September 18-20, 2006, as well as several reports unable to be presented during the meeting because of travel difficulties of the authors. The presentations in this volume have been organized into four sections: (1) pathophysiology of nervous system insults, (2) neurotrophic factors and neuroprotection, (3) nanotechniques and neuroprotection, and (4) additional approaches to neuroprotection. The first section considers several major factors crucial to nervous system insults in clinical settings. Neurotrophic factors have become a major topic in the study of neuroprotection, as reports in the second section show. Reports in teh third section show that nanotechnology has the potential for new approaches to neuroprotection at the cellular and molecular levels--in terms of both pharmacology and devices. The final section presents various other approaches to neuroprotection. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neuroprotective agents
KW - nervous system
KW - pathophysiology
KW - neurotrophic factors
KW - nanotechniques
KW - neuroprotection
KW - nanotechnology
KW - 2007
KW - Nervous System
KW - Neurosciences
KW - Pathophysiology
KW - Protective Factors
KW - Nanotechnology
KW - Neuroprotection
KW - 2007
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106259531
T1 - Adverse event monitoring and multivitamin-multimineral dietary supplements.
AU - Woo JJY
Y1 - 2007/01/02/Jan2007 Supplement
N1 - Accession Number: 106259531. Language: English. Entry Date: 20070330. Revision Date: 20150819. Publication Type: Journal Article. Supplement Title: Jan2007 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376027.
KW - Adverse Drug Event
KW - Dietary Supplementation -- Adverse Effects
KW - Minerals -- Adverse Effects
KW - Vitamins -- Adverse Effects
KW - Voluntary Reporting
KW - United States
KW - United States Food and Drug Administration
SP - 323S
EP - 4S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 85
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - A study commissioned by the Food and Drug Administration (FDA) estimated that the FDA is notified of < 1% of all adverse events associated with dietary supplements. Among the factors that may contribute to underreporting are that many consumers presume supplements to be safe, use these products without the supervision of a health care professional, and may be unaware that the FDA regulates them. In 2001 an Office of the Inspector General report identified many of the difficulties in evaluating adverse events in a voluntary system and the barriers to effective analysis of these reports to generate possible signals of concern. These include factors such as limited medical information, limited product information, limited manufacturer information, limited information on dietary supplement consumers, and limited ability to analyze trends. In addition, for dietary supplements, vital premarket information (which is available for drug products) is often missing so that possible public health concerns generated by the adverse event reporting system, such as limited clinical information, product identification, and information on consumer use, cannot be adequately assessed. Thus, the FDA is inherently limited in its ability to investigate signals of public health problems generated by the system. However, the FDA can use adverse event reports to identify areas of concern warranting further investigation. The FDA then initiates collaboration with federal partners to identify knowledge gaps in the safety of individual dietary ingredients and products and works with these partners to fill these information gaps to support appropriate regulatory action. Copyright © 2007 American Society for Nutrition
SN - 0002-9165
AD - Division of Dietary Supplement Programs, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA. jason.woo@fda.hhs.gov
U2 - PMID: 17209219.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Temple, Robert
AU - Stockbridge, Norman L.
T1 - BiDil for Heart Failure in Black Patients: The U.S. Food and Drug Administration Perspective.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/01/02/
VL - 146
IS - 1
M3 - Article
SP - 57
EP - W9
SN - 00034819
AB - Critics of the U.S. Food and Drug Administration (FDA) approval of the fixed combination of hydralazine hydrochloride, 37.5 mg, and isosorbide dinitrate, 20 mg, for treating heart failure in black patients have suggested that data were insufficient to distinguish treatment effects in black and white people; that distinctions based on race, rather than pathophysiology, were scientifically unreasonable; and that a "race-based" approval could be a commercial ploy to avoid a more expensive and prolonged full evaluation of a drug. The criticisms acknowledge that data supporting the approval came from a well-designed clinical trial in which self-identified black patients with heart failure who took hydralazine hydrochloride-isosorbide dinitrate with standard therapy experienced a statistically significant 43% (95% CI, 11% to 63%) reduction in mortality compared with those who took only the standard therapy. The criticisms do not always recognize that the decision to conduct the trial in only black patients reflected careful analyses of 2 previous trials in racially mixed patient populations that compared hydralazine hydrochloride-isosorbide dinitrate with placebo or with enalapril. Both trials showed little or no overall effect of hydralazine hydrochloride-isosorbide dinitrate in the mostly white patient population but hinted at a substantial effect in subsets of black patients. Perhaps most critically, the criticisms do not appreciate the urgency of strong scientific evidence of a substantial survival benefit in black patients. A serious attempt to avoid race-based approval by mandating study of a mixed population to identify a possible white patient-responder subset, particularly without a plausible hypothesis as to what that subset might be, would have required years of work, many thousands of patients, and wholly unreasonable delay in approval of a treatment whose effectiveness had been well-documented in the group for which it was intended. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART failure
KW - MEDICAL care
KW - HYDRALAZINE
KW - HEART diseases
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 23628835; Temple, Robert 1; Email Address: robert.temple@fda.hhs.gov Stockbridge, Norman L. 1; Affiliation: 1: U.S. Food and Drug Administration, Silver Spring, Maryland.; Source Info: 1/2/2007, Vol. 146 Issue 1, p57; Subject Term: HEART failure; Subject Term: MEDICAL care; Subject Term: HYDRALAZINE; Subject Term: HEART diseases; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106260151
T1 - BiDil for heart failure in black patients: the U.S. Food and Drug Administration perspective.
AU - Temple R
AU - Stockbridge NL
Y1 - 2007/01/02/
N1 - Accession Number: 106260151. Language: English. Entry Date: 20070330. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Blacks
KW - Cardiovascular Agents -- Therapeutic Use
KW - Drug Approval
KW - Heart Failure -- Drug Therapy
KW - Heart Failure -- Ethnology
KW - Hydralazine -- Therapeutic Use
KW - Isosorbide Dinitrate -- Therapeutic Use
KW - United States Food and Drug Administration
KW - Clinical Trials -- Standards
KW - Drug Combinations
KW - Public Policy
KW - United States
SP - 57
EP - 62
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 146
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - Critics of the U.S. Food and Drug Administration (FDA) approval of the fixed combination of hydralazine hydrochloride, 37.5 mg, and isosorbide dinitrate, 20 mg, for treating heart failure in black patients have suggested that data were insufficient to distinguish treatment effects in black and white people; that distinctions based on race, rather than pathophysiology, were scientifically unreasonable; and that a 'race-based' approval could be a commercial ploy to avoid a more expensive and prolonged full evaluation of a drug. The criticisms acknowledge that data supporting the approval came from a well-designed clinical trial in which self-identified black patients with heart failure who took hydralazine hydrochloride-isosorbide dinitrate with standard therapy experienced a statistically significant 43% (95% CI, 11% to 63%) reduction in mortality compared with those who took only the standard therapy. The criticisms do not always recognize that the decision to conduct the trial in only black patients reflected careful analyses of 2 previous trials in racially mixed patient populations that compared hydralazine hydrochloride-isosorbide dinitrate with placebo or with enalapril. Both trials showed little or no overall effect of hydralazine hydrochloride-isosorbide dinitrate in the mostly white patient population but hinted at a substantial effect in subsets of black patients. Perhaps most critically, the criticisms do not appreciate the urgency of strong scientific evidence of a substantial survival benefit in black patients. A serious attempt to avoid race-based approval by mandating study of a mixed population to identify a possible white patient-responder subset, particularly without a plausible hypothesis as to what that subset might be, would have required years of work, many thousands of patients, and wholly unreasonable delay in approval of a treatment whose effectiveness had been well-documented in the group for which it was intended.
SN - 0003-4819
AD - U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. robert.temple@fda.hhs.gov
U2 - PMID: 17200223.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106260151&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Muskhelishvili, Levan
AU - Rusyn, Ivan
AU - Ross, Sharon A.
T1 - Methyl Deficiency, Alterations in Global Histone Modifications, and Carcinogenesis.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2007/01/02/Jan2007 Supplement
VL - 137
M3 - Article
SP - 216S
EP - 222S
SN - 00223166
AB - The methyl-deficient model of endogenous hepatocarcinogenesis in rodents is unique in that dietary omission rather than the addition of chemical carcinogens leads to tumor formation. Thus, the biochemical and molecular events predisposing to cancer in this model result from chronic metabolic stress and provide an ideal model system to study progressive alterations that occur during carcinogenesis. Moreover, epigenetic alterations imposed by this diet are believed to be 1 of the main mechanisms responsible for malignant transformation of rat liver cells. In this study we examined the changes in global histone modification patterns in liver during hepatocarcinogenesis induced by methyl deficiency. Feeding animals the methyl-deficient diet (MDD) led to progressive loss of histone H4 lysine 20 trimethylation (H4K20me3), H3 lysine 9 trimethylation (H3K9me3), and histone H3 lysine 9 (H3K9ac) and histone H4 lysine 16 (H4K16ac) acetylation. A considerable decrease of H4K20me3 and H3K9ac was also detected in liver tumors induced by MDD. In contrast, liver tumors displayed an increase in H3K9me3 and H4K16ac. To determine the possible mechanism of alterations of histone modifications, we analyzed the expression of histone-modifying enzymes in liver during hepatocarcinogenesis. The expression of Suv4-20h2 and RIZ1 histone methyltransferases (HMTs) steadily decreased along with the development of liver tumors and reached its lowest level in tumor tissue, whereas the expression of Suv39-h1 HMT and histone acetyltransferase 1 (HAT1) substantially increased in tumors. These results illustrate the complexity and importance of histone modification changes in the etiology of hepatocarcinogenesis induced by MDD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTONES
KW - CARCINOGENESIS
KW - TUMORS -- Growth
KW - METHANOL
KW - DEFICIENCY diseases
KW - METABOLIC disorders
KW - CANCER -- Etiology
KW - DISEASES -- Causes & theories of causation
KW - CANCER research
N1 - Accession Number: 23593880; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Tryndyak, Volodymyr P. 1 Muskhelishvili, Levan 1 Rusyn, Ivan 2 Ross, Sharon A. 3; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR 72079 2: University of North Carolina, Chapel Hill, NC 27599 3: National Cancer Institute, Bethesda, MD 20852; Source Info: Jan2007 Supplement, Vol. 137, p216S; Subject Term: HISTONES; Subject Term: CARCINOGENESIS; Subject Term: TUMORS -- Growth; Subject Term: METHANOL; Subject Term: DEFICIENCY diseases; Subject Term: METABOLIC disorders; Subject Term: CANCER -- Etiology; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: CANCER research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
T1 - Gaps in Scientific Knowledge About the Carcinogenic Potential of Asphalt/Bitumen Fumes.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/01/02/Jan2007 Supplement 1
VL - 4
M3 - Article
SP - 3
EP - 5
PB - Taylor & Francis Ltd
SN - 15459624
AB - Despite a relatively large body of published research, the potential carcinogenicity of asphalt/bitumen fumes is still a vexing question. Various uncertainties and gaps in scientific knowledge need to be addressed. These include uncertainties in chemistry, animal studies, and human studies. The chemistry of asphalt/bitumen fumes is complex and varies according to the source of the crude oil and the application parameters. The epidemiological studies, while showing weak evidence of lung cancer, are inconsistent and many confounding factors have not been addressed. Studies of animal exposure are also inconsistent regarding laboratory and field-generated fumes. There is a need for further human studies that address potential confounding factors such as smoking, diet, coal tar, and diesel exposures. Animal inhalation studies need to be conducted with asphalt/bitumen fumes that are chemically representative of roofing and paving fumes. Underlying all of this is the need for continued characterization of fumes so their use in animal and field studies can be properly assessed. Nonetheless, uncertainties such as these should not preclude appropriate public health actions to protect workers in the even that asphalt fumes are found to be a carcinogenic hazard. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bitumen
KW - Asphalt
KW - Poisonous gases -- Toxicology
KW - Industrial hygiene
KW - Carcinogenicity
KW - Industrial safety
KW - Environmental health
KW - Chemistry
KW - Animal experimentation
KW - Lungs -- Cancer
KW - asphalt
KW - bitumen
KW - cancer
KW - fume
KW - inhalation
N1 - Accession Number: 25085301; Schulte, Paul A. 1; Email Address: pas4@cdc.gov; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Jan2007 Supplement 1, Vol. 4, p3; Thesaurus Term: Bitumen; Thesaurus Term: Asphalt; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Industrial hygiene; Thesaurus Term: Carcinogenicity; Thesaurus Term: Industrial safety; Thesaurus Term: Environmental health; Thesaurus Term: Chemistry; Thesaurus Term: Animal experimentation; Subject Term: Lungs -- Cancer; Author-Supplied Keyword: asphalt; Author-Supplied Keyword: bitumen; Author-Supplied Keyword: cancer; Author-Supplied Keyword: fume; Author-Supplied Keyword: inhalation; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 211114 Non-conventional oil extraction; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/15459620701354424
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Herrick, Robert F.
AU - McClean, Michael D.
AU - Meeker, John D.
AU - Zwack, Leonard
AU - Hanley, Kevin
T1 - Physical and Chemical Characterization of Asphalt (Bitumen) Paving Exposures.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/01/02/Jan2007 Supplement 1
VL - 4
M3 - Article
SP - 209
EP - 216
PB - Taylor & Francis Ltd
SN - 15459624
AB - The purpose of this research was to characterize the physical and chemical properties of asphalt (bitumen) fume and vapor in hot mix asphalt roadway paving operations. Area and personal air samples were taken using real-time equipment and extractive sampling and analytical methods to determine worker asphalt exposure, as well as to characterize the properties of the particulate and vapor phase components. Analysis of personal inhalation and dermal samples by gas chromatography/mass spectroscopy showed that the polycyclic aromatic hydrocarbon profile is dominated by compounds with molecular weights below 228, and that substituted and heterocyclic polycyclic aromatic hydrocarbons comprised approximately 71% of the detectable mass concentration (vapor and particulate combined). Principal components analysis shows that the polycyclic aromatic hydrocarbons with molecular weights greater than 190 are the driving force behind the polycyclic aromatic compound exposures measured for the dermal and particulate phases; there was no clear trend for the vapor phase Most of the aerosol particles are fine (mass median aerodynamic diameter 1.02 μ m; count median diameter 0.24 μ m). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt pavements
KW - Bitumen
KW - Polycyclic aromatic compounds
KW - Polycyclic aromatic hydrocarbons
KW - Aerosols (Sprays)
KW - Poisonous gases -- Toxicology
KW - Mass spectrometry
KW - Chromatographic analysis
KW - Industrial hygiene
KW - Paving industry
KW - Asphalt pavers
KW - aerosol size
KW - asphalt
KW - bitumen
KW - polycyclic aromatic compounds
KW - polycyclic aromatic hydrocarbons
N1 - Accession Number: 25085310; Herrick, Robert F. 1; Email Address: herrick@hohp.harvard.edu; McClean, Michael D. 2; Meeker, John D. 3; Zwack, Leonard 1; Hanley, Kevin 4; Affiliations: 1: Harvard School of Public Health, Boston, Massachusetts; 2: Boston University School of Public Health, Boston, Massachusetts; 3: University of Michigan, School of Public Health, Ann Arbor, Michigan; 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jan2007 Supplement 1, Vol. 4, p209; Thesaurus Term: Asphalt pavements; Thesaurus Term: Bitumen; Thesaurus Term: Polycyclic aromatic compounds; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Mass spectrometry; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Industrial hygiene; Subject Term: Paving industry; Subject Term: Asphalt pavers; Author-Supplied Keyword: aerosol size; Author-Supplied Keyword: asphalt; Author-Supplied Keyword: bitumen; Author-Supplied Keyword: polycyclic aromatic compounds; Author-Supplied Keyword: polycyclic aromatic hydrocarbons; NAICS/Industry Codes: 211114 Non-conventional oil extraction; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; NAICS/Industry Codes: 324121 Asphalt Paving Mixture and Block Manufacturing; NAICS/Industry Codes: 417210 Construction and forestry machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333120 Construction Machinery Manufacturing; Number of Pages: 8p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620701334806
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106199171
T1 - Gaps in scientific knowledge about the carcinogenic potential of asphalt/bitumen fumes.
AU - Schulte PA
Y1 - 2007/01/02/Jan2007 Supplement 1
N1 - Accession Number: 106199171. Language: English. Entry Date: 20071130. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Jan2007 Supplement 1. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational
KW - Construction Materials
KW - Hydrocarbons
KW - Neoplasms -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Neoplasms -- Epidemiology
KW - Uncertainty
SP - 3
EP - 5
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Despite a relatively large body of published research, the potential carcinogenicity of asphalt/bitumen fumes is still a vexing question. Various uncertainties and gaps in scientific knowledge need to be addressed. These include uncertainties in chemistry, animal studies, and human studies. The chemistry of asphalt/bitumen fumes is complex and varies according to the source of the crude oil and the application parameters. The epidemiological studies, while showing weak evidence of lung cancer, are inconsistent and many confounding factors have not been addressed. Studies of animal exposure are also inconsistent regarding laboratory and field-generated fumes. There is a need for further human studies that address potential confounding factors such as smoking, diet, coal tar, and diesel exposures. Animal inhalation studies need to be conducted with asphalt/bitumen fumes that are chemically representative of roofing and paving fumes. Underlying all of this is the need for continued characterization of fumes so their use in animal and field studies can be properly assessed. Nonetheless, uncertainties such as these should not preclude appropriate public health actions to protect workers in the even that asphalt fumes are found to be a carcinogenic hazard.
SN - 1545-9624
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Cincinnati, Ohio. USA.
U2 - PMID: 17503268.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chaffin, Jeffrey
AU - Moss, David
T1 - Review of Current U.S. Army Dental Emergency Rates.
JO - Military Medicine
JF - Military Medicine
Y1 - 2007/01/02/Jan2007 Supplement
VL - 173
M3 - Article
SP - 23
EP - 26
PB - AMSUS
SN - 00264075
AB - The purpose of this article was to review current dental emergency rates for U.S. Army personnel and to identify shortfalls in dental emergency research. The Department of Defense Dental Classification System is intended to identify military personnel at the greatest risk for dental emergencies, allowing military dental assets to prioritize dental treatment. Only two studies have been published on the emergency rates of U.S. Army Soldiers since 2000, both detailing emergency rates for Soldiers deployed to Bosnia. The Stabilization Force VII study identified that Soldiers experienced dental emergencies at a rate of 156 per 1,000 per year, whereas the Stabilization Force VIII study found the rate of 170 per 1,000 per year. No studies have been conducted for the Army during Operation Iraqi Freedom due to difficulty in capturing all dental treatment encounters. Researchers should attempt to standardize the nomenclature and definitions to aid in the comparability of future dental emergency rate studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL emergencies
KW - DENTAL care
KW - DENTAL research
KW - DEPLOYMENT (Military strategy)
KW - UNITED States. Army
KW - UNITED States
KW - UNITED States. Army -- Dental care
N1 - Accession Number: 28775542; Chaffin, Jeffrey 1 Moss, David 2; Affiliation: 1: Public Health Dental Officer, Office of the Surgeon General, Department of the Army, DASG-DC; 5109 Leesburg Pike, Suite 682, Falls Church, VA 22041 2: Public Health Dental Officer, U.S. Army Dental Command, 2050 Worth Road, Suite 4, Fort Sam Houston, TX 78234; Source Info: Jan2007 Supplement, Vol. 173, p23; Subject Term: DENTAL emergencies; Subject Term: DENTAL care; Subject Term: DENTAL research; Subject Term: DEPLOYMENT (Military strategy); Subject Term: UNITED States. Army; Subject Term: UNITED States; Company/Entity: UNITED States. Army -- Dental care; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, James J.
AU - Huey-Miin Hsueh
AU - Delongchamp, Robert R.
AU - Chien-Ju Lin
AU - Chen-An Tsai
T1 - Reproducibility of microarray data: a further analysis of microarray quality control (MAQC) data.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2007/01/03/2007 Supplement 2
VL - 8
M3 - Article
SP - 412
EP - 425
PB - BioMed Central
SN - 14712105
AB - Background: Many researchers are concerned with the comparability and reliability of microarray gene expression data. Recent completion of the MicroArray Quality Control (MAQC) project provides a unique opportunity to assess reproducibility across multiple sites and the comparability across multiple platforms. The MAQC analysis presented for the conclusion of inter- and intra-platform comparability/ reproducibility of microarray gene expression measurements is inadequate. We evaluate the reproducibility/comparability of the MAQC data for 12901 common genes in four titration samples generated from five high-density one-color microarray platforms and the TaqMan technology. We discuss some of the problems with the use of correlation coefficient as metric to evaluate the inter- and intraplatform reproducibility and the percent of overlapping genes (POG) as a measure for evaluation of a gene selection procedure by MAQC. Results: A total of 293 arrays were used in the intra- and inter-platform analysis. A hierarchical cluster analysis shows distinct differences in the measured intensities among the five platforms. A number of genes show a small fold-change in one platform and a large fold-change in another platform, even though the correlations between platforms are high. An analysis of variance shows thirty percent of gene expressions of the samples show inconsistent patterns across the five platforms. We illustrated that POG does not reflect the accuracy of a selected gene list. A non-overlapping gene can be truly differentially expressed with a stringent cut, and an overlapping gene can be non-differentially expressed with non-stringent cutoff. In addition, POG is an unusable selection criterion. POG can increase or decrease irregularly as cutoff changes; there is no criterion to determine a cutoff so that POG is optimized. Conclusion: Using various statistical methods we demonstrate that there are differences in the intensities measured by different platforms and different sites within platform. Within each platform, the patterns of expression are generally consistent, but there is site-by-site variability. Evaluation of data analysis methods for use in regulatory decision should take no treatment effect into consideration, when there is no treatment effect, "a fold-change cutoff with a non-stringent p-value cutoff" could result in 100% false positive error selection. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - GENE expression
KW - GENES
KW - PROTEIN folding
KW - SAMPLING (Statistics)
KW - GENETIC regulation
N1 - Accession Number: 35074266; Chen, James J. 1; Email Address: jamesj.chen@fda.hhs.gov Huey-Miin Hsueh 2; Email Address: hsueh@nccu.edu.tw Delongchamp, Robert R. 3; Email Address: rdelongchamp@uams.edu Chien-Ju Lin 1; Email Address: chien-ju.lin@fda.hhs.gov Chen-An Tsai 4; Email Address: catsai@mail.cmu.edu.tw; Affiliation: 1: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA 2: Department of Statistics, National ChengChi University, Taipei, Taiwan 3: Department of Epidemiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 4: Department of Public Health & Biostatistics Center, China Medical University, Taichung, Taiwan; Source Info: 2007 Supplement 2, Vol. 8, p412; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: GENES; Subject Term: PROTEIN folding; Subject Term: SAMPLING (Statistics); Subject Term: GENETIC regulation; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 14p; Document Type: Article
L3 - 10.1186/1471-2105-8-412
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pine, Michael
AU - Jordan, Harmon S.
AU - Elixhauser, Anne
AU - Fry, Donald E.
AU - Hoaglin, David C.
AU - Jones, Barbara
AU - Meimban, Roger
AU - Warner, David
AU - Gonzales, Junius
T1 - Enhancement of Claims Data to Improve Risk Adjustment of Hospital Mortality.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/01/03/
VL - 297
IS - 1
M3 - Article
SP - 71
EP - 76
SN - 00987484
AB - The authors present the results of their study into an assessment of whether adding admission codes and numerical laboratory data to risk adjustment analyses of hospital mortality rates adds value to these analyses. Since comparisons of risk-adjusted hospital performance are used in public reports and pay-for-performance programs, such analyses must contain enough clinical detail to accurately measure hospital quality. Their findings of this study support the value of adding these measures, however, secondary abstraction of difficult key clinical findings did not add to the predictive power of risk-adjustment equations.
KW - MORTALITY
KW - HOSPITAL care
KW - RESEARCH
KW - RISK assessment
KW - HOSPITALS -- Admission & discharge
KW - DIAGNOSIS
KW - INVOICES
N1 - Accession Number: 23575192; Pine, Michael 1,2; Email Address: mpine@aol.com Jordan, Harmon S. 3,4 Elixhauser, Anne 5 Fry, Donald E. 1 Hoaglin, David C. 3 Jones, Barbara 1 Meimban, Roger 1 Warner, David 3 Gonzales, Junius 3; Affiliation: 1: Michael Pine and Associates Inc., Chicago, Ill. 2: Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Ill 3: Abt Associates Inc, Cambridge, Mass. 4: School of Medicien, Tufts University, Boston, Mass. 5: Agency for Healthcare Research and Quality, Rockville, Md.; Source Info: 1/3/2007, Vol. 297 Issue 1, p71; Subject Term: MORTALITY; Subject Term: HOSPITAL care; Subject Term: RESEARCH; Subject Term: RISK assessment; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: DIAGNOSIS; Subject Term: INVOICES; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kessler, Larry G.
AU - Ramsey, Scott D.
T1 - The Forest and the Trees: the Human Costs of Cancer.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2007/01/03/
VL - 99
IS - 1
M3 - Editorial
SP - 2
EP - 3
SN - 00278874
AB - The authors reflect on the time cost of medical care for cancer patients. They present the by phase, initial, continuing and last-year-of-life, treatment for cancer care. The focus is on colon cancer. An overview of the findings of the study conducted that estimate the medical care cost for the disease which aims to inform those responsible for the development of public policy regarding cancer, funding of the National Cancer Institute research in particular, is offered.
KW - MEDICAL care costs
KW - CANCER treatment
KW - COLON cancer
KW - MEDICAL innovations
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 23728069; Kessler, Larry G. 1; Email Address: lgk@cdrh.fda.gov Ramsey, Scott D. 2; Affiliation: 1: Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 2: Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA; Source Info: 1/3/2007, Vol. 99 Issue 1, p2; Subject Term: MEDICAL care costs; Subject Term: CANCER treatment; Subject Term: COLON cancer; Subject Term: MEDICAL innovations; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1093/jnci/djk013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kauffman, John F.
AU - Dellibovi, Marybeth
AU - Cunningham, Charles R.
T1 - Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/01/04/
VL - 43
IS - 1
M3 - Article
SP - 39
EP - 48
SN - 07317085
AB - Abstract: Raman spectra of a set of coated pharmaceutical tablets were analyzed for the purpose of calibrating the spectra to tablet coating thickness. Acetaminophen tablets were coated with a hydroxypropylmethylcellulose/polyethylene glycol film coating whose thickness was varied from 0 to 6% weight gain. Coatings were also prepared with two concentrations of TiO2 at several film thicknesses. The resulting spectral data set was analyzed using several different multivariate calibration procedures. The procedures examined in this study included spectral correction followed by target factor analysis, spectral correction with baseline subtraction followed by principal component regression, and first derivative computation followed by principal component regression. The results demonstrate that target factor analysis is a viable method for calibration of Raman spectra to tablet coating thickness. Calibration based on derivative spectra resulted in linear correlation that was equal to that of the results of target factor analysis for coatings without TiO2. However, target factor analysis was found to be superior to other methods when TiO2 was present in the tablet coatings. The effect of sample fluorescence on each of these chemometric methods was also examined. It was found that when photobleaching of fluorescent impurities due to exposure to the Raman excitation source was controlled, the tablet coating thickness could be calibrated to the intensity of the fluorescence signal. The results also demonstrate that for the samples examined here, calibration by target factor analysis is insensitive to variation in fluorescent intensity when the tablet coating emission spectrum is included in the matrix of target vectors. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAMAN spectroscopy
KW - CALIBRATION
KW - TABLETS (Medicine)
KW - ACETAMINOPHEN
KW - Chemometrics
KW - Multivariate calibration
KW - Raman spectroscopy
KW - Tablet coating analysis
KW - Target factor analysis
N1 - Accession Number: 23351224; Kauffman, John F. 1; Email Address: John.Kauffman@fda.hhs.gov Dellibovi, Marybeth 1 Cunningham, Charles R. 2; Affiliation: 1: FDA, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States 2: Colorcon, Pharmaceutical Technical Services, 415 Moyer Blvd., West Point, PA 19486, United States; Source Info: Jan2007, Vol. 43 Issue 1, p39; Subject Term: RAMAN spectroscopy; Subject Term: CALIBRATION; Subject Term: TABLETS (Medicine); Subject Term: ACETAMINOPHEN; Author-Supplied Keyword: Chemometrics; Author-Supplied Keyword: Multivariate calibration; Author-Supplied Keyword: Raman spectroscopy; Author-Supplied Keyword: Tablet coating analysis; Author-Supplied Keyword: Target factor analysis; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jpba.2006.06.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, C.
AU - Sadovova, N.
AU - Ali, H.K.
AU - Duhart, H.M.
AU - Fu, X.
AU - Zou, X.
AU - Patterson, T.A.
AU - Binienda, Z.K.
AU - Virmani, A.
AU - Paule, M.G.
AU - Slikker, W.
AU - Ali, S.F.
T1 - l-Carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture
JO - Neuroscience
JF - Neuroscience
Y1 - 2007/01/05/
VL - 144
IS - 1
M3 - Article
SP - 46
EP - 55
SN - 03064522
AB - Abstract: 1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome with an elevation of intracellular reactive oxygen species (ROS) and apoptosis. l-Carnitine plays an integral role in attenuating the brain injury associated with mitochondrial neurodegenerative disorders. The present study investigates the effects of l-carnitine against the toxicity of MPP+ in rat forebrain primary cultures. Cells in culture were treated for 24 h with 100, 250, 500 and 1000 μM MPP+ alone or co-incubated with l-carnitine. MPP+ produced a dose-related increase in DNA fragmentation as measured by cell death ELISA (enzyme-linked immunosorbent assay), an increase in the number of TUNEL (terminal dUTP nick-end labeling)–positive cells and a reduction in the mitochondrial metabolism of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). No significant effect was observed with the release of lactate dehydrogenase (LDH), indicating that cell death presumably occurred via apoptotic mechanisms. Co-incubation of MPP+ with l-carnitine significantly reduced MPP+-induced apoptosis. Western blot analyses showed that neurotoxic concentrations of MPP+ decreased the ratio of BCL-XL to Bax and decreased the protein levels of polysialic acid neural cell adhesion molecules (PSA-NCAM), a neuron specific marker. l-Carnitine blocked these effects of MPP+ suggesting its potential therapeutic utility in degenerative disorders such as Parkinson’s disease, Alzheimer’s disease, ornithine transcarbamylase deficiency and other mitochondrial diseases. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARNITINE
KW - APOPTOSIS
KW - LACTATE dehydrogenase
KW - CELL adhesion
KW - 1-methyl-4-phenyl-1
KW - 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP )
KW - 1-methyl-4-phenylpyridinium ion
KW - 1-methyl-4-phenylpyridinium ion ( MPP+ )
KW - 2
KW - 3
KW - 3-(4
KW - 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide ( MTT )
KW - 5-dimethylthiazole-2-yl)-2
KW - 5-diphenyltetrazolium bromide ( MTT )
KW - 6-tetrahydropyridine ( MPTP )
KW - analysis of variance ( ANOVA )
KW - apoptosis
KW - Dulbecco’s modified Eagle’s medium ( DMEM )
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - glial fibrillary acidic protein ( GFAP )
KW - l-carnitine
KW - lactate dehydrogenase ( LDH )
KW - MPP+
KW - neurodegeneration
KW - neuronal rescue
KW - organic cation transporter ( OCT )
KW - polysialic acid neural cell adhesion molecule ( PSA-NCAM )
KW - postnatal day ( PND )
KW - reactive oxygen species ( ROS )
KW - terminal dUTP nick-end labeling ( TUNEL )
N1 - Accession Number: 23353286; Wang, C. 1; Email Address: cheng.wang@fda.hhs.gov Sadovova, N. 2 Ali, H.K. 1 Duhart, H.M. 1 Fu, X. 3 Zou, X. 1 Patterson, T.A. 1 Binienda, Z.K. 1 Virmani, A. 4 Paule, M.G. 1 Slikker, W. 1 Ali, S.F. 1; Email Address: syed.ali@fda.hhs.gov; Affiliation: 1: Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Toxicologic Pathology Associates, Jefferson, AR 72079, USA 3: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, AR 70729, USA 4: Research and Development, Sigma-tau HealthScience S.p.A., Via Treviso 4, 00040 Pomezia (Rome), Italy; Source Info: Jan2007, Vol. 144 Issue 1, p46; Subject Term: CARNITINE; Subject Term: APOPTOSIS; Subject Term: LACTATE dehydrogenase; Subject Term: CELL adhesion; Author-Supplied Keyword: 1-methyl-4-phenyl-1; Author-Supplied Keyword: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ); Author-Supplied Keyword: 1-methyl-4-phenylpyridinium ion; Author-Supplied Keyword: 1-methyl-4-phenylpyridinium ion ( MPP+ ); Author-Supplied Keyword: 2; Author-Supplied Keyword: 3; Author-Supplied Keyword: 3-(4; Author-Supplied Keyword: 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: 5-dimethylthiazole-2-yl)-2; Author-Supplied Keyword: 5-diphenyltetrazolium bromide ( MTT ); Author-Supplied Keyword: 6-tetrahydropyridine ( MPTP ); Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: Dulbecco’s modified Eagle’s medium ( DMEM ); Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: l-carnitine; Author-Supplied Keyword: lactate dehydrogenase ( LDH ); Author-Supplied Keyword: MPP+; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: neuronal rescue; Author-Supplied Keyword: organic cation transporter ( OCT ); Author-Supplied Keyword: polysialic acid neural cell adhesion molecule ( PSA-NCAM ); Author-Supplied Keyword: postnatal day ( PND ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: terminal dUTP nick-end labeling ( TUNEL ); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.neuroscience.2006.08.083
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowyer, J.F.
AU - Pogge, A.R.
AU - Delongchamp, R.R.
AU - O’Callaghan, J.P.
AU - Patel, K.M.
AU - Vrana, K.E.
AU - Freeman, W.M.
T1 - A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes
JO - Neuroscience
JF - Neuroscience
Y1 - 2007/01/05/
VL - 144
IS - 1
M3 - Article
SP - 66
EP - 76
SN - 03064522
AB - Abstract: Compulsive drug abuse has been conceptualized as a behavioral state where behavioral stimuli override normal decision making. Clinical studies of methamphetamine users have detailed decision making changes and imaging studies have found altered metabolism and activation in the parietal cortex. To examine the molecular effects of amphetamine (AMPH) on the parietal cortex, gene expression responses to amphetamine challenge (7.5 mg/kg) were examined in the parietal cortex of rats pretreated for nine days with either saline, non-neurotoxic amphetamine, or neurotoxic AMPH dosing regimens. The neurotoxic AMPH exposure [three doses of 7.5 mg/kg/day AMPH (6 h between doses), for nine days] produced histological signs of neurotoxicity in the parietal cortex while a non-neurotoxic dosing regimen (2.0 mg/kg/day×3) did not. Neurotoxic AMPH pretreatment resulted in significantly diminished AMPH challenge-induced mRNA increases of activity-regulated cytoskeletal protein (ARC), nerve growth-factor inducible protein A (NGFI-A), and nerve growth-factor inducible protein B (NGFI-B) in the parietal cortex while neither saline pretreatment nor non-neurotoxic AMPH pretreatment did. This effect was specific to these genes as tissue plasminogen activator (t-PA), neuropeptide Y (NPY) and c-jun expression in response to AMPH challenge was unaltered or enhanced by amphetamine pretreatments. In the striatum, there were no differences between saline, neurotoxic AMPH, and non-neurotoxic AMPH pretreatments on ARC, NGFI-A or NGFI-B expression elicited by the AMPH challenge. These data indicate that the responsiveness of synaptic plasticity-related genes is sensitive to disruption specifically in the parietal cortex by threshold neurotoxic AMPH exposures. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPHETAMINES
KW - DRUG abuse
KW - NEUROTOXICOLOGY
KW - GENE expression
KW - activity-related cytoskeletal protein
KW - activity-related cytoskeletal protein ( ARC )
KW - amphetamine
KW - amphetamine ( AMPH )
KW - challenge
KW - Egr1
KW - Fluoro-Jade C ( FJ-C )
KW - gene expression
KW - glial fibrillary acidic protein ( GFAP )
KW - glyceraldehyde-3-phosphate dehydrogenase ( GAPDH )
KW - KROX24) ( NGFI-A )
KW - methamphetamine ( METH )
KW - N-methyl-d-aspartate ( NMDA )
KW - nerve growth factor inducible protein A (aka
KW - nerve growth factor inducible protein A (aka, Egr1, ZIF/268, KROX24) ( NGFI-A )
KW - nerve growth factor inducible protein B (aka
KW - nerve growth factor inducible protein B (aka, Nurr77, Nr4a1) ( NGFI-B )
KW - nerve growth-factor inducible proteins
KW - neuropeptide Y protein ( NPY )
KW - neurotoxicity
KW - Nr4a1) ( NGFI-B )
KW - Nurr77
KW - tissue plasminogen activator ( t-PA )
KW - ZIF/268
N1 - Accession Number: 23353288; Bowyer, J.F. 1; Email Address: john.bowyer@fda.hhs.gov Pogge, A.R. 1 Delongchamp, R.R. 2 O’Callaghan, J.P. 3 Patel, K.M. 4 Vrana, K.E. 4 Freeman, W.M. 4; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, Jefferson, AR 72079, USA 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Toxicology and Molecular Biology Branch, CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA 4: Department of Pharmacology, Penn State College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033-0850, USA; Source Info: Jan2007, Vol. 144 Issue 1, p66; Subject Term: AMPHETAMINES; Subject Term: DRUG abuse; Subject Term: NEUROTOXICOLOGY; Subject Term: GENE expression; Author-Supplied Keyword: activity-related cytoskeletal protein; Author-Supplied Keyword: activity-related cytoskeletal protein ( ARC ); Author-Supplied Keyword: amphetamine; Author-Supplied Keyword: amphetamine ( AMPH ); Author-Supplied Keyword: challenge; Author-Supplied Keyword: Egr1; Author-Supplied Keyword: Fluoro-Jade C ( FJ-C ); Author-Supplied Keyword: gene expression; Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ); Author-Supplied Keyword: KROX24) ( NGFI-A ); Author-Supplied Keyword: methamphetamine ( METH ); Author-Supplied Keyword: N-methyl-d-aspartate ( NMDA ); Author-Supplied Keyword: nerve growth factor inducible protein A (aka; Author-Supplied Keyword: nerve growth factor inducible protein A (aka, Egr1, ZIF/268, KROX24) ( NGFI-A ); Author-Supplied Keyword: nerve growth factor inducible protein B (aka; Author-Supplied Keyword: nerve growth factor inducible protein B (aka, Nurr77, Nr4a1) ( NGFI-B ); Author-Supplied Keyword: nerve growth-factor inducible proteins; Author-Supplied Keyword: neuropeptide Y protein ( NPY ); Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: Nr4a1) ( NGFI-B ); Author-Supplied Keyword: Nurr77; Author-Supplied Keyword: tissue plasminogen activator ( t-PA ); Author-Supplied Keyword: ZIF/268; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.neuroscience.2006.08.076
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smetana, Gerald W.
AU - Landon, Bruce F.
AU - Bindman, Andrew B.
AU - Burstin, Helen
AU - Davis, Roger B.
AU - Tjia, Jennifer
AU - Rich, Eugene C.
T1 - A Comparison of Outcomes Resulting From Generalist vs Specialist Care for a Single Discrete Medical Condition.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2007/01/08/
VL - 167
IS - 1
M3 - Article
SP - 10
EP - 20
SN - 00039926
AB - The article presents a systematic review and methodologic critique of results in medical care. It presents a comparison of outcomes from generalist against specialist care for a single medical condition. The literature on the influence of generalist vs specialist care is fully discussed in this paper.
KW - MEDICAL care
KW - PHYSICIANS (General practice)
KW - MEDICINE -- Specialties & specialists
KW - MEDICINE
KW - PROFESSIONS
N1 - Accession Number: 23693450; Smetana, Gerald W. 1; Email Address: gsmetana@bidmc.harvard.edu Landon, Bruce F. 1,2 Bindman, Andrew B. 3 Burstin, Helen 4 Davis, Roger B. 1 Tjia, Jennifer 5 Rich, Eugene C. 6; Affiliation: 1: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center 2: Department of Health Care Policy, Harvard Medical School, Boston, Mass 3: Division of General Internal Medicine, San Francisco General Hospital, University of California, San Francisco 4: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Md 5: Division of Geriatric Medicine, University of Pennsylvania School of Medicine, Philadelphia (Dr Tjia) 6: Department of Medicine, Creighton University School of Medicine, Omaha, Neb; Source Info: 1/8/2007, Vol. 167 Issue 1, p10; Subject Term: MEDICAL care; Subject Term: PHYSICIANS (General practice); Subject Term: MEDICINE -- Specialties & specialists; Subject Term: MEDICINE; Subject Term: PROFESSIONS; NAICS/Industry Codes: 813920 Professional Organizations; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schnackenberg, Laura K.
AU - Jinchun Sun
AU - Espandiari, Parvaneh
AU - Holland, Ricky D.
AU - Hanig, Joseph
AU - Beger, Richard D.
T1 - Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2007/01/08/2007 Supplement 7
VL - 8
M3 - Article
SP - S3
EP - 14
PB - BioMed Central
SN - 14712105
AB - Background: Urine from male Sprague-Dawley rats 25, 40, and 80 days old was analyzed by NMR and UPLC/MS. The effects of data normalization procedures on principal component analysis (PCA) and quantitative analysis of NMR-based metabonomics data were investigated. Additionally, the effects of age on the metabolic profiles were examined by both NMR and UPLC/MS analyses. Results: The data normalization factor was shown to have a great impact on the statistical and quantitative results indicating the need to carefully consider how to best normalize the data within a particular study and when comparing different studies. PCA applied to the data obtained from both NMR and UPLC/MS platforms reveals similar age-related differences. NMR indicated many metabolites associated with the Krebs cycle decrease while citrate and 2-oxoglutarate, also associated with the Krebs cycle, increase in older rats. Conclusion: This study compared four different normalization methods for the NMR-based metabonomics spectra from an age-related study. It was shown that each method of normalization has a great effect on both the statistical and quantitative analyses. Each normalization method resulted in altered relative positions of significant PCA loadings for each sample spectra but it did not alter which chemical shifts had the highest loadings. The greater the normalization factor was related to age, the greater the separation between age groups was observed in subsequent PCA analyses. The normalization factor that showed the least age dependence was total NMR intensity, which was consistent with UPLC/MS data. Normalization by total intensity attempts to make corrections due to dietary and water intake of the individual animal, which is especially useful in metabonomics evaluations of urine. Additionally, metabonomics evaluations of age-related effects showed decreased concentrations of many Krebs cycle intermediates along with increased levels of oxidized antioxidants in urine of older rats, which is consistent with current theories on aging and its association with diminishing mitochondrial function and increasing levels of reactive oxygen species. Analysis of urine by both NMR and UPLC/MS provides a comprehensive and complementary means of examining metabolic events in aging rats. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRINCIPAL components analysis
KW - QUANTITATIVE chemical analysis
KW - METABOLIC profile tests
KW - METABOLISM -- Testing
KW - KREBS cycle
KW - URINALYSIS
KW - SPRAGUE Dawley rats
KW - RATS as laboratory animals
KW - METABOLITES
KW - CITRATES
N1 - Accession Number: 28677635; Schnackenberg, Laura K. 1; Email Address: laura.schnackenberg@fda.hhs.gov Jinchun Sun 2; Email Address: jsun@uams.edu Espandiari, Parvaneh 3; Email Address: parvaneh.espandiari@fda.hhs.gov Holland, Ricky D. 1; Email Address: ricky.holland@fda.hhs.gov Hanig, Joseph 3; Email Address: joseph.hanig@fda.hhs.gov Beger, Richard D. 1; Email Address: richard.beger@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research (NCTR), Jefferson, AR, 72079, USA 2: University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA 3: Center for Drug Evaluation and Research (CDER), Silver Spring, MD, 20993, USA; Source Info: 2007 Supplement 7, Vol. 8, pS3; Subject Term: PRINCIPAL components analysis; Subject Term: QUANTITATIVE chemical analysis; Subject Term: METABOLIC profile tests; Subject Term: METABOLISM -- Testing; Subject Term: KREBS cycle; Subject Term: URINALYSIS; Subject Term: SPRAGUE Dawley rats; Subject Term: RATS as laboratory animals; Subject Term: METABOLITES; Subject Term: CITRATES; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1186/1471-2105-8-S7-S3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nan Mei
AU - Lei Guo
AU - Ruqing Liu
AU - Fuscoe, James C.
AU - Tao Chen
T1 - Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2007/01/08/2007 Supplement 7
VL - 8
M3 - Article
SP - S4
EP - 12
PB - BioMed Central
SN - 14712105
AB - Background: Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plants grown in the western United States and is a prototype of genotoxic PAs. Riddelliine was used to investigate the genotoxic effects of PAs via analysis of gene expression in the target tissue of rats in this study. Previously we observed that the mutant frequency in the liver of rats gavaged with riddelliine was 3-fold higher than that in the control group. Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats. Results: Riddelliine-induced gene expression profiles in livers of Big Blue transgenic rats were determined. The female rats were gavaged with riddelliine at a dose of 1 mg/kg body weight 5 days a week for 12 weeks. Rat whole genome microarray was used to perform genome-wide gene expression studies. When a cutoff value of a two-fold change and a P-value less than 0.01 were used as gene selection criteria, 919 genes were identified as differentially expressed in riddelliine-treated rats compared to the control animals. By analysis with the Ingenuity Pathway Analysis Network, we found that these significantly changed genes were mainly involved in cancer, cell death, tissue development, cellular movement, tissue morphology, cell-to-cell signaling and interaction, and cellular growth and proliferation. We further analyzed the genes involved in metabolism, injury of endothelial cells, liver abnormalities, and cancer development in detail. Conclusion: The alterations in gene expression were directly related to the pathological outcomes reported previously. These results provided further insight into the mechanisms involved in toxicity and carcinogenesis after exposure to riddelliine, and permitted us to investigate the interaction of gene products inside the signaling networks. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - PYRROLIZIDINES
KW - LIVER tumors
KW - RATS as laboratory animals
KW - POISONS -- Analysis
KW - GENETIC toxicology
KW - CELL death
KW - MORPHOLOGY
KW - WEST (U.S.)
KW - UNITED States
N1 - Accession Number: 28677636; Nan Mei 1; Email Address: nan.mei@fda.hhs.gov Lei Guo 2; Email Address: lei.guo@fda.hhs.gov Ruqing Liu 3,4; Email Address: liuruqing@hotmail.com Fuscoe, James C. 2; Email Address: james.fuscoe@fda.hhs.gov Tao Chen 1; Email Address: tao.chen@fda.hhs.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 4: School of Public Health, Sun Yat-sen University, Guangzhou 510089, P. R. China; Source Info: 2007 Supplement 7, Vol. 8, pS4; Subject Term: GENE expression; Subject Term: PYRROLIZIDINES; Subject Term: LIVER tumors; Subject Term: RATS as laboratory animals; Subject Term: POISONS -- Analysis; Subject Term: GENETIC toxicology; Subject Term: CELL death; Subject Term: MORPHOLOGY; Subject Term: WEST (U.S.); Subject Term: UNITED States; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
L3 - 10.1186/1471-2105-8-S7-S4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lei Guo
AU - Nan Mei
AU - Dial, Stacey
AU - Fuscoe, James
AU - Tao Chen
T1 - Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2007/01/08/2007 Supplement 7
VL - 8
M3 - Article
SP - S22
EP - 10
PB - BioMed Central
SN - 14712105
AB - Background: Comfrey (Symphytum officinale) is a perennial plant and has been consumed by humans as a vegetable, a tea and an herbal medicine for more than 2000 years. It, however, is hepatotoxic and carcinogenic in experimental animals and hepatotoxic in humans. Pyrrolizidine alkaloids (PAs) exist in many plants and many of them cause liver toxicity and/or cancer in humans and experimental animals. In our previous study, we found that the mutagenicity of comfrey was associated with the PAs contained in the plant. Therefore, we suggest that carcinogenicity of comfrey result from those PAs. To confirm our hypothesis, we compared the expression of genes and processes of biological functions that were altered by comfrey (mixture of the plant with PAs) and riddelliine (a prototype of carcinogenic PA) in rat liver for carcinogenesis in this study. Results: Groups of 6 Big Blue Fisher 344 rats were treated with riddelliine at 1 mg/kg body weight by gavage five times a week for 12 weeks or fed a diet containing 8% comfrey root for 12 weeks. Animals were sacrificed one day after the last treatment and the livers were isolated for gene expression analysis. The gene expressions were investigated using Applied Biosystems Rat Whole Genome Survey Microarrays and the biological functions were analyzed with Ingenuity Analysis Pathway software. Although there were large differences between the significant genes and between the biological processes that were altered by comfrey and riddelliine, there were a number of common genes and function processes that were related to carcinogenesis. There was a strong correlation between the two treatments for fold-change alterations in expression of drug metabolizing and cancer-related genes. Conclusion: Our results suggest that the carcinogenesis-related gene expression patterns resulting from the treatments of comfrey and riddelliine are very similar, and PAs contained in comfrey are the main active components responsible for carcinogenicity of the plant. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPARATIVE studies
KW - GENE expression
KW - COMFREY
KW - ANIMAL diseases
KW - LIVER -- Cancer
KW - PERENNIAL vegetables
KW - HERBAL medicine
KW - HEPATOTOXICOLOGY
KW - CARCINOGENICITY
KW - PYRROLIZIDINES
N1 - Accession Number: 28677632; Lei Guo 1; Email Address: lei.guo@fda.hhs.gov Nan Mei 2; Email Address: nan.mei@fda.hhs.gov Dial, Stacey 1; Email Address: stacey.dial@fda.hhs.gov Fuscoe, James 1; Email Address: jame.fuscoe@fda.hhs.gov Tao Chen 2; Email Address: tao.chen@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: 2007 Supplement 7, Vol. 8, pS22; Subject Term: COMPARATIVE studies; Subject Term: GENE expression; Subject Term: COMFREY; Subject Term: ANIMAL diseases; Subject Term: LIVER -- Cancer; Subject Term: PERENNIAL vegetables; Subject Term: HERBAL medicine; Subject Term: HEPATOTOXICOLOGY; Subject Term: CARCINOGENICITY; Subject Term: PYRROLIZIDINES; Number of Pages: 10p; Illustrations: 1 Color Photograph, 3 Diagrams, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1471-2105-8-S7-S22
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harada, Kouji
AU - Koizumi, Akio
AU - Saito, Norimitsu
AU - Inoue, Kayoko
AU - Yoshinaga, Takeo
AU - Date, Chigusa
AU - Fujii, Shigeo
AU - Hachiya, Noriyuki
AU - Hirosawa, Iwao
AU - Koda, Shigeki
AU - Kusaka, Yukinori
AU - Murata, Katsuyuki
AU - Omae, Kazuyuki
AU - Shimbo, Shinichiro
AU - Takenaka, Katsunobu
AU - Takeshita, Tatsuya
AU - Todoriki, Hidemi
AU - Wada, Yasuhiko
AU - Watanabe, Takao
AU - Ikeda, Masayuki
T1 - Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan
JO - Chemosphere
JF - Chemosphere
Y1 - 2007/01/08/
VL - 66
IS - 2
M3 - Article
SP - 293
EP - 301
SN - 00456535
AB - Abstract: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n =100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n =200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49ng/ml/year and 0.42ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003–2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLLUTION
KW - BLOOD plasma
KW - STANDARD deviations
KW - ANALYSIS of variance
KW - Geographical difference
KW - Long-term trend
KW - Perfluorooctane sulfonate
KW - Perfluorooctanoate
KW - Serum
N1 - Accession Number: 23215669; Harada, Kouji 1 Koizumi, Akio 1; Email Address: koizumi@pbh.med.kyoto-u.ac.jp Saito, Norimitsu 2 Inoue, Kayoko 1 Yoshinaga, Takeo 1 Date, Chigusa 3 Fujii, Shigeo 4 Hachiya, Noriyuki 5 Hirosawa, Iwao 6 Koda, Shigeki 7 Kusaka, Yukinori 8 Murata, Katsuyuki 9 Omae, Kazuyuki 10 Shimbo, Shinichiro 11 Takenaka, Katsunobu 12 Takeshita, Tatsuya 13 Todoriki, Hidemi 14 Wada, Yasuhiko 15 Watanabe, Takao 16 Ikeda, Masayuki 17; Affiliation: 1: Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Kyoto 606-8501, Japan 2: Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka 020-0852, Japan 3: Faculty of Human life and Environment, Nara Women’s University, Nara 630-8506, Japan 4: Research Center for Environmental Quality Control, Kyoto University Graduate School of Engineering, Ohtsu 520-0811, Japan 5: Department of International Affairs and Environmental Sciences, National Institute for Minamata Disease, Minamata 867-0055, Japan 6: Kansai University of Welfare Sciences, Osaka 582-0026, Japan 7: Japan National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan 8: Department of Environmental Health, School of Medicine, University of Fukui, Matsuoka, Fukui 910-1193, Japan 9: Department of Environmental Health Sciences, Akita University School of Medicine, Akita 010-8543, Japan 10: Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo 160-8582, Japan 11: Kyoto Women’s University, Kyoto 605-8501, Japan 12: Department of Neurosurgery, Takayama Red Cross Hospital, Takayama 506-8550, Japan 13: Department of Public Health, Wakayama Medical University, Wakayama 641-8509, Japan 14: Department of Preventive Medicine, Faculty of Medicine, University of the Ryukyus, Nakagashira 903-0215, Japan 15: Department of Medical Informatics, Japan Labour Health and Welfare Organization, Kansai Rosai Hospital, Amagasaki 660-8511, Japan 16: Miyagi University of Education, Sendai 980-0845, Japan 17: Kyoto Industrial Health Association, Kyoto 604-8472, Japan; Source Info: Jan2007, Vol. 66 Issue 2, p293; Subject Term: POLLUTION; Subject Term: BLOOD plasma; Subject Term: STANDARD deviations; Subject Term: ANALYSIS of variance; Author-Supplied Keyword: Geographical difference; Author-Supplied Keyword: Long-term trend; Author-Supplied Keyword: Perfluorooctane sulfonate; Author-Supplied Keyword: Perfluorooctanoate; Author-Supplied Keyword: Serum; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chemosphere.2006.05.010
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Basak, Arup K.
AU - Raw, Andre S.
AU - Yu, Lawrence X.
T1 - Pharmaceutical impurities: Analytical, toxicological and regulatory perspectives
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2007/01/10/
VL - 59
IS - 1
M3 - Editorial
SP - 1
EP - 2
SN - 0169409X
N1 - Accession Number: 23946324; Basak, Arup K.; Email Address: arup.basak@fda.hhs.gov Raw, Andre S. 1; Email Address: andre.raw@fda.hhs.gov Yu, Lawrence X. 1; Email Address: lawrence.yu@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research — Office of Generic Drugs, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Jan2007, Vol. 59 Issue 1, p1; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.addr.2006.10.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23946324&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacobson-Kram, David
AU - McGovern, Timothy
T1 - Toxicological overview of impurities in pharmaceutical products
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2007/01/10/
VL - 59
IS - 1
M3 - Article
SP - 38
EP - 42
SN - 0169409X
AB - Abstract: While the use of pharmaceuticals is always a balance of risks and benefits, the same is not true for impurities in pharmaceuticals; impurities convey only risk. A number of international guidelines and regional guidances instruct drug developers and regulatory agencies on how to evaluate and control impurities in drug substances and drug products. While impurities should always be reduced to the lowest levels that are reasonably practical, it is acknowledged that impurities cannot be reduced to zero and specifications for impurities need to be established. This chapter discusses practical and theoretical methods for qualification of different classes of impurities. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Toxicology
KW - MANUFACTURING industries -- Defects
KW - RISK management in business
KW - PHARMACEUTICAL industry
KW - European Medicines Agency (EMEA)
KW - Genotoxic impurities
KW - Pharmaceutical impurities
KW - Toxicology
N1 - Accession Number: 23946328; Jacobson-Kram, David 1; Email Address: david.jacobsonkram@fda.hhs.gov McGovern, Timothy 2; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Office of New Drugs, Division of Pulmonary and Allergy Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Jan2007, Vol. 59 Issue 1, p38; Subject Term: DRUGS -- Toxicology; Subject Term: MANUFACTURING industries -- Defects; Subject Term: RISK management in business; Subject Term: PHARMACEUTICAL industry; Author-Supplied Keyword: European Medicines Agency (EMEA); Author-Supplied Keyword: Genotoxic impurities; Author-Supplied Keyword: Pharmaceutical impurities; Author-Supplied Keyword: Toxicology; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.addr.2006.10.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kruhlak, Naomi L.
AU - Contrera, Joseph F.
AU - Benz, R. Daniel
AU - Matthews, Edwin J.
T1 - Progress in QSAR toxicity screening of pharmaceutical impurities and other FDA regulated products
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2007/01/10/
VL - 59
IS - 1
M3 - Article
SP - 43
EP - 55
SN - 0169409X
AB - Abstract: Active ingredients in pharmaceutical products undergo extensive testing to ensure their safety before being made available to the American public. A consideration during the regulatory review process is the safety of pharmaceutical contaminants and degradents which may be present in the drug product at low levels. Several published guidances are available that outline the criteria for further testing of these impurities to assess their toxic potential, where further testing is in the form of a battery of toxicology assays and the identification of known structural alerts. However, recent advances in the development of computational methods have made available additional resources for safety assessment such as structure similarity searching and quantitative structure–activity relationship (QSAR) models. These methods offer a rapid and cost-effective first-pass screening capability to assess toxicity when conventional toxicology data are limited or lacking, with the potential to identify compounds that would be appropriate for further testing. This article discusses some of the considerations when using computational toxicology methods for regulatory decision support and gives examples of how the technology is currently being applied at the US Food and Drug Administration. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - CLINICAL drug trials
KW - MANUFACTURING industries -- Defects
KW - DRUG development
KW - Carcinogenicity
KW - Drug development
KW - Genotoxicity
KW - In silico screening
KW - OECD principles
KW - Predictive toxicology
N1 - Accession Number: 23946329; Kruhlak, Naomi L. 1 Contrera, Joseph F.; Email Address: joseph.contrera@fda.hhs.gov Benz, R. Daniel 1 Matthews, Edwin J. 1; Affiliation: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Jan2007, Vol. 59 Issue 1, p43; Subject Term: TOXICOLOGY; Subject Term: CLINICAL drug trials; Subject Term: MANUFACTURING industries -- Defects; Subject Term: DRUG development; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: In silico screening; Author-Supplied Keyword: OECD principles; Author-Supplied Keyword: Predictive toxicology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.addr.2006.10.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23946329&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Basak, Arup K.
AU - Raw, Andre S.
AU - Al Hakim, Ali H.
AU - Furness, Scott
AU - Samaan, Nashed I.
AU - Gill, Devinder S.
AU - Patel, Hasmukh B.
AU - Powers, Roslyn F.
AU - Yu, Lawrence
T1 - Pharmaceutical impurities: Regulatory perspective for Abbreviated New Drug Applications
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2007/01/10/
VL - 59
IS - 1
M3 - Article
SP - 64
EP - 72
SN - 0169409X
AB - Abstract: Impurities in drug substances and drug products have been important regulatory issues in the Office of Generic Drugs by having significant impact on the approvability of Abbreviated New Drug Application (ANDAs). This review begins with a discussion of ANDAs and its similarity/differences with NDAs, highlighting the importance of control of pharmaceutical impurities in generic drug product development and regulatory assessment. An overview of the FDA draft guidance documents “ANDAs: Impurities in Drug Substances” and “ANDAs: Impurities in Drug Products” are provided. This introduces the identification and qualification procedures for ANDAs and approaches to the establishment of acceptance criteria for both drug substance and drug product. Case studies included in this review illustrate the proposed pathway for determination of impurities and their acceptance criteria, based upon the general principles of these guidances. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANUFACTURING industries -- Defects
KW - DRUGS
KW - DRUG development
KW - GENERIC drugs
KW - Abbreviated New Drug Applications (ANDAs)
KW - Drug product
KW - Drug substance
KW - Impurity
N1 - Accession Number: 23946331; Basak, Arup K. 1; Email Address: arup.basak@fda.hhs.gov Raw, Andre S. 1 Al Hakim, Ali H. 2 Furness, Scott 1 Samaan, Nashed I. 1 Gill, Devinder S. 1 Patel, Hasmukh B. 2 Powers, Roslyn F. 1 Yu, Lawrence 1; Affiliation: 1: Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA 2: Office of New Drug Quality Assessment, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Jan2007, Vol. 59 Issue 1, p64; Subject Term: MANUFACTURING industries -- Defects; Subject Term: DRUGS; Subject Term: DRUG development; Subject Term: GENERIC drugs; Author-Supplied Keyword: Abbreviated New Drug Applications (ANDAs); Author-Supplied Keyword: Drug product; Author-Supplied Keyword: Drug substance; Author-Supplied Keyword: Impurity; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.addr.2006.10.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23946331&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yoon, Diana M.
AU - Hawkins, Emily C.
AU - Francke-Carroll, Sabine
AU - Fisher, John P.
T1 - Effect of construct properties on encapsulated chondrocyte expression of insulin-like growth factor-1
JO - Biomaterials
JF - Biomaterials
Y1 - 2007/01/10/
VL - 28
IS - 2
M3 - Article
SP - 299
EP - 306
SN - 01429612
AB - Abstract: Hydrogels are a promising type of biomaterial for articular cartilage constructs since they have been shown to enable encapsulated chondrocytes to express their predominant phenotypic marker, type II collagen. Endogenously expressed signaling molecules, such as insulin-like growth factor-1 (IGF-1), are also known to facilitate the retention of this chondrocytic phenotype. Recent investigations have attempted to enhance the ability of encapsulated chondrocytes to regenerate cartilage through delivery of exogenous signaling molecules. However, we hypothesize that by altering construct properties, such as cell density and polymer concentration, we can augment the expression of endogenous IGF-1 in chondrocytes. To this end, bovine articular chondrocytes were encapsulated within alginate hydrogels at two different cell densities (25,000 and 100,000 cells/bead) and various alginate concentrations (0.8%, 1.2%, and 2.0% w/v). These parameters were chosen to simultaneously investigate cell-to-cell distance on paracrine signaling and water content on IGF-1 diffusion by chondrocytes. At 1, 4, and 8d, chondrocytes were analyzed for protein and mRNA expression of IGF-1 as well as type II collagen. Results suggest that cell density and alginate concentration at high cell density can significantly affect the endogenous IGF-1 expression by chondrocytes. Therefore, these results indicate that construct properties can impact chondrocyte gene expression and should be considered in order to create a proper engineered articular cartilage construct. [Copyright &y& Elsevier]
AB - Copyright of Biomaterials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARTILAGE cells
KW - GROWTH factors
KW - COLLAGEN
KW - GENETIC regulation
KW - Alginate
KW - Cell signaling
KW - Chondrocyte
KW - Insulin-like growth factor-1
N1 - Accession Number: 22723550; Yoon, Diana M. 1 Hawkins, Emily C. 2 Francke-Carroll, Sabine 2 Fisher, John P. 3; Email Address: http://www.glue.umd.edu/~jpfisher; Affiliation: 1: Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA 2: Pathology Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA 3: Fischell Department of Bioengineering, University of Maryland, 3238 Jeong H. Kim Engineering Building, College Park, MD 20742, USA; Source Info: Jan2007, Vol. 28 Issue 2, p299; Subject Term: CARTILAGE cells; Subject Term: GROWTH factors; Subject Term: COLLAGEN; Subject Term: GENETIC regulation; Author-Supplied Keyword: Alginate; Author-Supplied Keyword: Cell signaling; Author-Supplied Keyword: Chondrocyte; Author-Supplied Keyword: Insulin-like growth factor-1; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.biomaterials.2006.08.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Jianyong
AU - Heflich, Robert H.
AU - Moore, Martha M.
T1 - A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/01/10/
VL - 626
IS - 1/2
M3 - Article
SP - 185
EP - 190
SN - 13835718
AB - Abstract: The mouse lymphoma assay (MLA) is the most widely used in vitro mammalian gene mutation assay. It detects various mutation events involving the thymidine kinase (Tk) gene in L5178Y/Tk +/− −3.7.2C mouse lymphoma cells. Mutants are detected using a thymidine analogue that arrests the growth of cells containing a functional Tk gene. However, there are a number of potential test chemicals that are thymidine analogues, and there is a problem when using the MLA to evaluate the mutagenicity of these chemicals. Thymidine analogues are activated by Tk before eliciting their toxicity. Therefore, any pre-existing Tk −/− mutants may avoid the toxicity of the test chemical and obtain a growth advantage over the Tk +/− cells, increasing the Tk mutant frequency (MF) in the culture via a selection mechanism. This potential mutant selection effect needs to be distinguished from de novo mutant induction in order to properly evaluate the mutagenicity of these chemicals. Here we describe a simple MLA study design that can differentiate between the selection of pre-existing mutants and de novo mutant induction. Trifluorothymidine (TFT), a thymidine analogue and the selection agent normally used in the MLA, and 4-nitroquinoline-1-oxide (4-NQO), a potent mutagen, were used to treat cells from two different Tk +/− mouse lymphoma cell cultures with different background MFs (approximately 112 and 305×10−6). Both agents significantly increased the Tk MFs in both the normal and high background cultures (p <0.01). In 4-NQO-treated cultures, the induced MFs (MF of treated culture−MF of control) for the cultures with different background MFs were about the same (p >0.1), while in TFT-treated cultures, they were significantly different (p <0.01). In TFT-treated cultures, the fold-increases of MF (MF of treated culture/MF of control) for the cultures with different background MFs were about the same (p >0.1), while in 4-NQO-treated cultures, they were significantly different (p <0.01). This study confirms that, when de novo mutations are induced, the induced MF is the same for cultures with normal and artificially high background MFs. In situations where the increase in MF is due solely to selection of pre-existing mutants, the “induced” MF will be a multiple of the background MF and the magnitude of the increase of the induced MF will depend upon the magnitude of the background MF. Our results demonstrate that it is possible, using this experimental design, to distinguish between chemicals acting primarily via the selection of pre-existing Tk mutants and those inducing de novo mutants in the MLA. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Lymphomas
KW - Thymidine
KW - Cultures (Biology)
KW - Mouse lymphoma assay
KW - Mutant frequency
KW - Mutant selection
KW - Thymidine analogue
N1 - Accession Number: 23449758; Wang, Jianyong 1,2; Email Address: jianyong.wang@fda.hhs.gov; Heflich, Robert H. 2; Moore, Martha M. 2; Affiliations: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Jan2007, Vol. 626 Issue 1/2, p185; Thesaurus Term: Mutation (Biology); Subject Term: Lymphomas; Subject Term: Thymidine; Subject Term: Cultures (Biology); Author-Supplied Keyword: Mouse lymphoma assay; Author-Supplied Keyword: Mutant frequency; Author-Supplied Keyword: Mutant selection; Author-Supplied Keyword: Thymidine analogue; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.09.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kingsley, David H.
AU - Holliman, Daniel R.
AU - Calci, Kevin R.
AU - Haiqiang Chen
AU - Flick, George J.
T1 - Inactivation of a Norovirus by High-Pressure Processing.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/01/15/
VL - 73
IS - 2
M3 - Article
SP - 581
EP - 585
SN - 00992240
AB - Murine norovirus (strain MNV-1), a propagable norovirus, was evaluated for susceptibility to high-pressure processing. Experiments with virus stocks in Dulbecco's modified Eagle medium demonstrated that at room temperature (20°C) the virus was inactivated over a pressure range of 350 to 450 MPa, with a 5-min, 450-MPa treatment being sufficient to inactivate 6.85 log10 PFU of MNV-1. The inactivation of MNV.1 was enhanced when pressure was applied at an initial temperature of 5°C; a 5-min pressure treatment of 350 MPa at 30°C inactivated 1.15 log10 PFU of virus, while the same treatment at 5°C resulted in a reduction of 5.56 log10 PFU. Evaluation of virus inactivation as a function of treatment times ranging from 0 to 150 s and 0 to 900 s at 5°C and 20°C, respectively, indicated that a decreasing rate of inactivation with time was consistent with Weibull or log-logistic inactivation kinetics. The inactivation of MNV-1 directly within oyster tissues was demonstrated; a 5-min, 400-MPa treatment at 5°C was sufficient to inactivate 4.05 log10 PFU. This work is the first demonstration that norovirus can be inactivated by high pressure and suggests good prospects for inactivation of nonpropagable human norovirus strains in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS inactivation
KW - PRESSURE
KW - AMERICAN oyster
KW - CRASSOSTREA
KW - TISSUE culture
KW - CULTURES (Biology)
KW - WEIBULL distribution
KW - LOGARITHMIC functions
KW - TRANSCENDENTAL functions
N1 - Accession Number: 23933869; Kingsley, David H. 1; Email Address: dkingsle@desu.edu Holliman, Daniel R. 2 Calci, Kevin R. 3 Haiqiang Chen 4 Flick, George J. 2; Affiliation: 1: U.S. Department of Agriculture, Agriculture Research Service, Microbial Food Safety Research Unit, James W. W. Baker Center, Delaware State University, Dover, Delaware 19901 2: Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 3: U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528 4: Department of Animal & Food Sciences, University of Delaware, Newark, Delaware 19716-2150; Source Info: Jan2007, Vol. 73 Issue 2, p581; Subject Term: VIRUS inactivation; Subject Term: PRESSURE; Subject Term: AMERICAN oyster; Subject Term: CRASSOSTREA; Subject Term: TISSUE culture; Subject Term: CULTURES (Biology); Subject Term: WEIBULL distribution; Subject Term: LOGARITHMIC functions; Subject Term: TRANSCENDENTAL functions; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 5p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1128/AEM.02117-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mertens, Paul L. J. M.
AU - Borsboom, Gerard J. J. M.
AU - Richardus, Jan Hendrik
T1 - A Pertussis Outbreak Associated with Social Isolation among Elderly Nuns in a Convent.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/01/15/
VL - 44
IS - 2
M3 - Article
SP - 266
EP - 268
SN - 10584838
AB - The pertussis incidence during an outbreak in a convent in The Netherlands in 1992 was higher among 75 retired (unvaccinated) nuns (60%) than among 24 staff members (8%) and was higher among 9 nuns with only a convent career (100%) than among 66 nuns who had a career outside of the convent (55%). The pertussis incidence increased with duration of social isolation but not with age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Vaccination
KW - Whooping cough
KW - Nuns
KW - Social isolation
KW - Netherlands
N1 - Accession Number: 23502439; Mertens, Paul L. J. M. 1,2; Email Address: paul.mertens@planet.n; Borsboom, Gerard J. J. M. 1; Richardus, Jan Hendrik 1,2; Affiliations: 1: Department of Public Health, Erasmus MC, University Medical Center Rotterdam; 2: Municipal Public Health Service Rotterdam Area, Rotterdam, The Netherlands; Issue Info: 1/15/2007, Vol. 44 Issue 2, p266; Thesaurus Term: Epidemics; Thesaurus Term: Vaccination; Subject Term: Whooping cough; Subject Term: Nuns; Subject Term: Social isolation; Subject: Netherlands; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Taylor, Melanie M.
AU - Rotblatt, Harlan
AU - Brooks, John T.
AU - Montoya, Jorge
AU - Aynalem, Getahun
AU - Smith, Lisa
AU - Kenney, Kerry
AU - Laubacher, Lori
AU - Bustamante, Tony
AU - Kim-Farley, Robert
AU - Fielding, Jonathan
AU - Bernard, Bruce
AU - Daar, Eric
AU - Kerndt, Peter R.
T1 - Epidemiologic Investigation of a Cluster of Workplace HIV Infections in the Adult Film Industry: Los Angeles, California, 2004.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/01/15/
VL - 44
IS - 2
M3 - Article
SP - 301
EP - 305
SN - 10584838
AB - Background. Adult film production is a legal, multibillion dollar industry in California. In response to reports of human immunodeficiency virus (HIV) transmission by an adult film worker, we sought to determine the extent of HIV infection among exposed workers and to identify means of improving worker safety. Methods. The Los Angeles County Department of Health Services initiated an outbreak investigation that included interviews of infected workers to elicit information about recent sex partners, review of the testing agency's medical records and laboratory results, molecular analysis of HIV isolates from the 4 infected workers, and a risk assessment of HIV transmission in the adult film industry. Results. Many adult film workers participate in a monthly program of screening for HIV infection by means of polymerase chain reaction-based technology to detect HIV DNA in blood. A male performer tested negative for HIV on 12 February 2004 and 17 March 2004, then tested positive for HIV on 9 April 2004. During the period between the negative test results, he experienced a flulike illness after performing unprotected vaginal and anal intercourse for an adult film produced outside the United States by a US company. After returning to California, he performed unprotected sex acts for adult films with 13 female partners who had all tested negative for HIV in the preceding 30 days; 3 subsequently tested positive for HIV (a 23% attack rate). Contact tracing identified no reasonable sources of infection other than the male index patient. Conclusion. Although current testing methods may shorten the window period to diagnosis of new HIV infection, they fail to prevent occupational acquisition of HIV in this setting. A California Occupational Safety and Health Administration-approved written health and safety program that emphasizes primary prevention is needed for this industry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - Health services administration
KW - Medical care
KW - Polymerase chain reaction
KW - Sexual intercourse
KW - Medical informatics
N1 - Accession Number: 23502445; Taylor, Melanie M. 1,2,3; Email Address: taylorm@azdhs.gov; Rotblatt, Harlan 2; Brooks, John T. 4; Montoya, Jorge 2; Aynalem, Getahun 2; Smith, Lisa 2; Kenney, Kerry 1,2,3; Laubacher, Lori 1,2; Bustamante, Tony 2,5; Kim-Farley, Robert 2; Fielding, Jonathan 2; Bernard, Bruce 6; Daar, Eric 7; Kerndt, Peter R. 2; Affiliations: 1: Division of STD Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia; 2: Los Angeles Department of Public Health, Los Angeles; 3: Arizona Department of Health Services, Phoenix; 4: Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia; 5: California State STD Control Branch, California Department of Health Services, Berkeley; 6: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, CDC, Cincinnati, Ohio; 7: Division of HIV Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California; Issue Info: 1/15/2007, Vol. 44 Issue 2, p301; Subject Term: HIV infections; Subject Term: Health services administration; Subject Term: Medical care; Subject Term: Polymerase chain reaction; Subject Term: Sexual intercourse; Subject Term: Medical informatics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Kuempel, Eileen D.
AU - Tran, Lang
AU - Castranova, Vincent
AU - Bailer, A. John
T1 - Response to Dr. Morfeld's Letter.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2007/01/15/
VL - 19
IS - 2
M3 - Letter
SP - 197
EP - 198
SN - 08958378
AB - A response by Eileen D. Kuempel, Lang Tran, Vincent Castranova, and John Bailer to a letter to the editor about their article "Lung Dosimetry and Risk Assessment of Nanoparticles: Evaluating and Extending Current Models in Rats and Humans" issue is presented.
KW - Letters to the editor
KW - Toxicology -- Animal models
N1 - Accession Number: 23429980; Kuempel, Eileen D. 1; Tran, Lang 2; Castranova, Vincent 3; Bailer, A. John 4; Affiliations: 1: National Institute for Occupational Safety and Health Cincinnati, Ohio, USA; 2: Institute of Occupational Medicine Edinburgh, Scotland, United Kingdom; 3: National Institute for Occupational Safety and Health Morgantown, West Virginia, USA; 4: Miami University Oxford, Ohio, USA; Issue Info: Jan2007, Vol. 19 Issue 2, p197; Subject Term: Letters to the editor; Subject Term: Toxicology -- Animal models; Number of Pages: 2p; Document Type: Letter
L3 - 10.1080/08958370601056650
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23429980&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vallyathan, Val
AU - Pack, Donna
AU - Leonard, Steve
AU - Lawson, Robert
AU - Schenker, Marc
AU - Castranova, Vince
T1 - Comparative in Vitro Toxicity of Grape- and Citrus-Farm Dusts.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/01/15/
VL - 70
IS - 2
M3 - Article
SP - 95
EP - 106
SN - 15287394
AB - Agricultural workers are exposed to a variety of airborne dusts, including crystalline silica and other inorganic minerals. This study was designed to characterize the organic and inorganic components of agricultural dusts in California grape- and citrus-farm fields and to compare their cytotoxicity using in vitro toxicity bioassays as predictors of pathogenicity. Aerosolized dusts collected from farm fields were characterized by scanning-electron-microscopic energy-dispersive x-ray analysis, x-ray diffraction, trace metal analysis by plasma emission spectroscopy, and surface area measurements. As indicators of cytotoxicity, cell viability, release of alveolar enzymes activities (lactate dehydrogenase, N-acetyl glucosaminidase), production of reactive oxygen species (ROS), such as H2O2 and hydroxyl radical (OH), and lipid peroxidation were monitored after exposure of cells to grape- and citrus-farm dusts or inorganic components of these dusts. In addition, activation of nuclear factor κ B and activator protein-1 were evaluated at the peak time for response of 36 h postexposure. All toxicity studies were done in comparison with crystalline silica of similar particle size and diameter using the same mass concentrations as farm dusts. The results showed that inorganic minerals in the aerosolized farm dust fractions were mostly composed of aluminum silicates, crystalline silica, and free iron. Crystalline silica used in these studies was more cytotoxic than grape- and citrus-farm dusts. However, in general, citrus farm dust exhibited the greatest ability to generate ROS and induce lipid peroxidation. These results support human epidemiologic studies, reporting an increased incidence of pulmonary fibrosis in farm workers, by documenting the potential of farm dusts to induce oxidative stress and initiate disease development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURAL laborers
KW - TOXICOLOGY
KW - SILICA
KW - AEROSOLS (Sprays)
KW - AIR pollution
KW - CYTOCHEMICAL bioassay
KW - TOXICOLOGICAL emergencies
KW - PULMONARY fibrosis
KW - EMISSION spectroscopy
N1 - Accession Number: 24155266; Vallyathan, Val 1; Email Address: vavl@cdc.gov Pack, Donna 1 Leonard, Steve 1 Lawson, Robert 2 Schenker, Marc 2 Castranova, Vince 1; Affiliation: 1: Pathology and Physiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Department of Public Health Sciences, University of California, Davis, California, USA; Source Info: Jan2007, Vol. 70 Issue 2, p95; Subject Term: AGRICULTURAL laborers; Subject Term: TOXICOLOGY; Subject Term: SILICA; Subject Term: AEROSOLS (Sprays); Subject Term: AIR pollution; Subject Term: CYTOCHEMICAL bioassay; Subject Term: TOXICOLOGICAL emergencies; Subject Term: PULMONARY fibrosis; Subject Term: EMISSION spectroscopy; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 12p; Illustrations: 4 Charts, 10 Graphs; Document Type: Article
L3 - 10.1080/15287390600747825
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Poljakovic, Mirjana
AU - Porter, Dale W.
AU - Millecchia, Lyndell
AU - Kepka-Lenhart, Diane
AU - Beighley, Christopher
AU - Wolfarth, Michael G.
AU - Castranova, Vincent
AU - Morris Jr., Sidney M.
T1 - Cell- and Isoform-Specific Increases in Arginase Expression in Acute Silica-Induced Pulmonary Inflammation.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/01/15/
VL - 70
IS - 2
M3 - Article
SP - 118
EP - 127
SN - 15287394
AB - Arginase induction was reported in several inflammatory lung diseases, suggesting that this may be a common feature underlying the pathophysiology of such diseases. As little is known regarding arginase expression in silicosis, the induction and cellular localization of arginase were elucidated in lungs of Sprague-Dawley rats 24 h following exposure to varying doses of silica by intratracheal instillation. Arginase expression was evaluated by activity assay, quantification of arginase I and arginase II mRNA levels using real-time polymerase chain reaction (PCR), and immunohistochemistry. Analyses of cells and fluid obtained by bronchoalveolar lavage (BAL) showed that markers of pulmonary inflammation, tissue damage, activation of alveolar macrophages (AM) and NO production were significantly increased by all silica doses. Arginase activity was increased also in AMs isolated from BAL fluid of silica-treated rats. Silica produced two- and three-fold increases in arginase activity of whole lung at doses of 1 and 5 mg/100 g body weight, respectively. Levels of arginase I mRNA, but not of arginase II mRNA, were similarly elevated. In control lungs, arginase I immunoreactivity was observed only in AMs sparsely dispersed throughout the lung; no inducible nitric oxide synthase (iNOS) immunoreactivity was detected. In silica-treated lungs, arginase I and iNOS were co-expressed in most AMs that were abundantly clustered at inflammatory foci. The rapid induction of arginase I expression in inflammatory lung cells, similar to induction of arginase in other inflammatory lung diseases, implicates elevated arginase activity as a factor in the development of lung damage following exposure to silica. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNG diseases
KW - SILICOSIS
KW - SILICA
KW - BRONCHOALVEOLAR lavage
KW - MESSENGER RNA
KW - POLYMERASE chain reaction
KW - IMMUNOHISTOCHEMISTRY
KW - MACROPHAGES
KW - RATS as laboratory animals
N1 - Accession Number: 24155263; Poljakovic, Mirjana 1 Porter, Dale W. 2 Millecchia, Lyndell 2 Kepka-Lenhart, Diane 1 Beighley, Christopher 2 Wolfarth, Michael G. 2 Castranova, Vincent 2 Morris Jr., Sidney M. 1; Email Address: smorris@pitt.edu; Affiliation: 1: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Jan2007, Vol. 70 Issue 2, p118; Subject Term: LUNG diseases; Subject Term: SILICOSIS; Subject Term: SILICA; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: MESSENGER RNA; Subject Term: POLYMERASE chain reaction; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: MACROPHAGES; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 10p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390600755075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24155263&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Noonan, G.O.
AU - Begley, T.H.
AU - Diachenko, G.W.
T1 - Rapid quantitative and qualitative confirmatory method for the determination of monofluoroacetic acid in foods by liquid chromatography–mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2007/01/19/
VL - 1139
IS - 2
M3 - Article
SP - 271
EP - 278
SN - 00219673
AB - Abstract: A rapid quantitative method and a qualitative confirmatory method for the determination of monofluoroacetic acid (MFA) in complex food matrices are presented. The quantitative method utilizes a water extraction, solid phase extraction clean-up and liquid chromatography–mass spectrometry (LC–MS) for determination of MFA. This method showed a high degree of specificity, detecting MFA in all of the spiked samples, while none of the unfortified samples tested positive for MFA. Spike recoveries were high in all matrices analyzed, varying from 85 to 110%, and comparable at low (2mg/L) and high (20mg/L) spiking levels. Repeatability tests at the low spiking levels yielded RSDs of less than 5% for all matrices analyzed. The qualitative confirmatory method developed is conceptually different from the quantitative method, ensuring that both methods would not be subject to the same interferences. The method uses the formation of the hydrazide of MFA through derivatization with 2-nitrophenylhydrazine. This derivatization is well established for the determination of carboxylic acids, but this is the first application to the determination of MFA. The derivatization yield was matrix dependent, however the limit of detection (LOD) (0.8μg/L) was sufficient to confirm the presence of MFA in all spiked matrices. Repeatability tests at the low spiking levels yielded RSDs of approximately 7% for all matrices analyzed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Liquid chromatography
KW - Mass spectrometry
KW - Nuclear spectroscopy
KW - Fluoroacetic acid
KW - Food adulteration
N1 - Accession Number: 23515982; Noonan, G.O.; Email Address: Gregory.noonan@fda.hhs.gov; Begley, T.H. 1; Diachenko, G.W. 1; Affiliations: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Jan2007, Vol. 1139 Issue 2, p271; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Liquid chromatography; Thesaurus Term: Mass spectrometry; Subject Term: Nuclear spectroscopy; Author-Supplied Keyword: Fluoroacetic acid; Author-Supplied Keyword: Food adulteration; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.chroma.2006.11.034
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nijdam, A. Jasper
AU - Ming-Cheng Cheng, Mark
AU - Geho, David H.
AU - Fedele, Roberta
AU - Herrmann, Paul
AU - Killian, Keith
AU - Espina, Virginia
AU - Petricoin, Emanuel F.
AU - Liotta, Lance A.
AU - Ferrari, Mauro
T1 - Physicochemically modified silicon as a substrate for protein microarrays
JO - Biomaterials
JF - Biomaterials
Y1 - 2007/01/20/
VL - 28
IS - 3
M3 - Article
SP - 550
EP - 558
SN - 01429612
AB - Abstract: Reverse phase protein microarrays (RPMA) enable high throughput screening of posttranslational modifications of important signaling proteins within diseased cells. One limitation of protein-based molecular profiling is the lack of a PCR-like intrinsic amplification system for proteins. Enhancement of protein microarray sensitivities is an important goal, especially because many molecular targets within patient tissues are of low abundance. The ideal array substrate will have a high protein-binding affinity and low intrinsic signal. To date, nitrocellulose-coated glass has provided an effective substrate for protein binding in the microarray format when using chromogenic detection systems. As fluorescent systems, such as quantum dots, are explored as potential reporter agents, the intrinsic fluorescent properties of nitrocellulose-coated glass slides limit the ability to image microarrays for extended periods of time where increases in net sensitivity can be attained. Silicon, with low intrinsic autofluorescence, is being explored as a potential microarray surface. Native silicon has low binding potential. Through titrated reactive ion etching (RIE), varying surface areas have been created on silicon in order to enhance protein binding. Further, via chemical modification, reactive groups have been added to the surfaces for comparison of relative protein binding. Using this combinatorial method of surface roughening and surface coating, 3-aminopropyltriethoxysilane (APTES) and mercaptopropyltrimethoxysilane (MPTMS) treatments were shown to transform native silicon into a protein-binding substrate comparable to nitrocellulose. [Copyright &y& Elsevier]
AB - Copyright of Biomaterials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICON
KW - PROTEIN microarrays
KW - BIOCHIPS
KW - BIOCHEMISTRY
KW - Protein adsorption
KW - Silicon
KW - Surface modification
KW - Surface treatment
N1 - Accession Number: 22949048; Nijdam, A. Jasper 1 Ming-Cheng Cheng, Mark 1,2 Geho, David H. 3 Fedele, Roberta 3 Herrmann, Paul 3 Killian, Keith 3 Espina, Virginia 3 Petricoin, Emanuel F. 4 Liotta, Lance A. 3 Ferrari, Mauro 2,5; Email Address: Mauro.Ferrari@uth.tmc.edu; Affiliation: 1: Comprehensive Cancer Center, The Ohio State University, 473 W 12th Ave, #326 Columbus, OH 43210, USA 2: The University of Texas Health Science Center at Houston, 7000 Fannin, Suite 1550, Houston, TX 77030, USA 3: Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA 4: Center for Biologics Evaluation, Food and Drug Administration, Bethesda, MD 20857, USA 5: Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA; Source Info: Jan2007, Vol. 28 Issue 3, p550; Subject Term: SILICON; Subject Term: PROTEIN microarrays; Subject Term: BIOCHIPS; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Protein adsorption; Author-Supplied Keyword: Silicon; Author-Supplied Keyword: Surface modification; Author-Supplied Keyword: Surface treatment; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.biomaterials.2006.08.051
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kimchi-Sarfaty, Chava
AU - Jung Mi Oh
AU - In-Wha Kim
AU - Sauna, Zuben E.
AU - Calcagno, Anna Maria
AU - Ambudkar, Suresh V.
AU - Gottesman, Michael M.
T1 - A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity.
JO - Science
JF - Science
Y1 - 2007/01/26/
VL - 315
IS - 5811
M3 - Article
SP - 525
EP - 528
SN - 00368075
AB - Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions. Similar mRNA and protein levels, but altered conformations, were found for wild-type and polymorphic P-gp. We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - GENETIC code
KW - NUCLEOTIDE sequence
KW - GENETIC transcription
KW - DRUG resistance
KW - PHARMACOLOGY
KW - MESSENGER RNA
KW - GLYCOPROTEINS
KW - PROTEINS
N1 - Accession Number: 23907197; Kimchi-Sarfaty, Chava 1,2; Email Address: kimchi@cber.fda.gov Jung Mi Oh 3; Email Address: jmoh@snu.ac.kr In-Wha Kim 1 Sauna, Zuben E. 1 Calcagno, Anna Maria 1 Ambudkar, Suresh V. 1 Gottesman, Michael M. 1; Email Address: mgottesman@nih.ogv; Affiliation: 1: Laboratory of Cell Biology, Center for Cancer Research National Cancer Institute, Bethesda, MD 20892, USA. 2: Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive Room 316, Bethesda, MD 20892, USA. 3: College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.; Source Info: 1/26/2007, Vol. 315 Issue 5811, p525; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC code; Subject Term: NUCLEOTIDE sequence; Subject Term: GENETIC transcription; Subject Term: DRUG resistance; Subject Term: PHARMACOLOGY; Subject Term: MESSENGER RNA; Subject Term: GLYCOPROTEINS; Subject Term: PROTEINS; Number of Pages: 4p; Document Type: Article
L3 - 10.1126/science.1135308
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fricke, Michael
AU - Zeller, Matthias
AU - Cullen, William
AU - Witkowski, Mark
AU - Creed, John
T1 - Dimethylthioarsinic anhydride: A standard for arsenic speciation
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2007/01/30/
VL - 583
IS - 1
M3 - Article
SP - 78
EP - 83
SN - 00032670
AB - Abstract: Dimethylthioarsinic acid (DMTAV) has recently been identified in biological, dietary and environmental matrices. The relevance of this compound to the toxicity of arsenic in humans is unknown and further exposure assessment and metabolic studies are difficult to conduct because of the unavailability of a well characterized standard. The synthesis of DMTAV was accomplished by the reaction of dimethylarsinic acid (DMAV) with hydrogen sulfide. The initial reaction product produced is DMTAV but multiple products over the course of the reaction are also observed. Therefore, a chromatographic separation was developed to monitor the reaction progress via LC–ICP-MS. In this synthesis, conversion of DMAV to DMTAV was not taken to completion to avoid the production of side products. The product was isolated from the starting material by standard organic techniques. Single crystal diffraction demonstrated that solid DMTAV is present in the form of the oxygen-bridged dimethylthioarsinic anhydride. Dissolution of the anhydride in water produces the acid form of DMTAV and the aqueous phase DMTAV provided a characteristic molecular ion of m/z 155 by LC–ESI-MS. The synthesis and isolation of dimethylthioarsinic anhydride provides a stable crystalline standard suitable for identification, toxicological study and exposure assessment of dimethylthioarsinic acid. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARSENIC
KW - ELECTROSPRAY ionization mass spectrometry
KW - CACODYLIC acid
KW - ORGANIC acids
KW - Dimethylarsinic acid
KW - Dimethylarsinothioic acid
KW - Electrospray ionization-mass spectrometry
KW - Hydrogen sulfide
KW - Inductively coupled plasma-mass spectrometry
KW - Speciation
N1 - Accession Number: 23604615; Fricke, Michael 1 Zeller, Matthias 2 Cullen, William 3 Witkowski, Mark 4 Creed, John 1; Email Address: creed.jack@epa.gov; Affiliation: 1: United States Environmental Protection Agency, National Exposure Research Laboratory, Microbiological and Chemical Exposure Assessment Research Division, 26 W. Martin Luther King Drive, Cincinnati, OH 45268, USA 2: STaRBURSTT-Cyberdiffraction Consortium, Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH 44555-3663, USA 3: Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1 4: Food and Drug Administration, Forensic Chemistry Center, Vibrational Spectroscopy Laboratory, 6751 Steger Drive, Cincinnati, OH 45237, USA; Source Info: Jan2007, Vol. 583 Issue 1, p78; Subject Term: ARSENIC; Subject Term: ELECTROSPRAY ionization mass spectrometry; Subject Term: CACODYLIC acid; Subject Term: ORGANIC acids; Author-Supplied Keyword: Dimethylarsinic acid; Author-Supplied Keyword: Dimethylarsinothioic acid; Author-Supplied Keyword: Electrospray ionization-mass spectrometry; Author-Supplied Keyword: Hydrogen sulfide; Author-Supplied Keyword: Inductively coupled plasma-mass spectrometry; Author-Supplied Keyword: Speciation; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.aca.2006.09.048
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Michael Keane
AU - David Murray
AU - William Chisholm
AU - Andrew Maynard
AU - Tong-man Ong
T1 - Phospholipid lung surfactant and nanoparticle surface toxicity: Lessons from diesel soots and silicate dusts.
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
Y1 - 2007/01/30/
VL - 9
IS - 1
M3 - Article
SP - 23
EP - 38
SN - 13880764
AB - Abstract??Because of their small size, the specific surface areas of nanoparticulate materials (NP), described as particles having at least one dimension smaller than 100?nm, can be large compared with micrometer-sized respirable particles. This high specific surface area or nanostructural surface properties may affect NP toxicity in comparison with micrometer-sized respirable particles of the same overall composition. Respirable particles depositing on the deep lung surfaces of the respiratory bronchioles or alveoli will contact pulmonary surfactants in the surface hypophase. Diesel exhaust ultrafine particles and respirable silicate micrometer-sized insoluble particles can adsorb components of that surfactant onto the particle surfaces, conditioning the particles surfaces and affecting theirin vitroexpression of cytotoxicity or genotoxicity. Those effects can be particle surface composition-specific. Effects of particle surface conditioning by a primary component of phospholipid pulmonary surfactant, diacyl phosphatidyl choline, are reviewed forin vitroexpression of genotoxicity by diesel exhaust particles and of cytotoxicity by respirable quartz and aluminosilicate kaolin clay particles. Those effects suggest methods and cautions for assaying and interpreting NP properties and biological activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanoparticle Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - PHOSPHOLIPIDS
KW - SURFACE active agents
KW - TOXINS
N1 - Accession Number: 23651090; Michael Keane 1 David Murray 1 William Chisholm 1 Andrew Maynard 2 Tong-man Ong 1; Affiliation: 1: US National Institute for Occupational Safety and Health 1095 Willowdale Road Morgantown WV 26505 USA 1095 Willowdale Road Morgantown WV 26505 USA 2: Woodrow Wilson International Center for Scholars Woodrow Wilson Plaza, 1300 Pennsylvania Avenue, N.W. Washington, DC 2004-3027 USA Woodrow Wilson Plaza, 1300 Pennsylvania Avenue, N.W. Washington, DC 2004-3027 USA; Source Info: Jan2007, Vol. 9 Issue 1, p23; Subject Term: NANOPARTICLES; Subject Term: PHOSPHOLIPIDS; Subject Term: SURFACE active agents; Subject Term: TOXINS; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andrew Maynard
AU - Bon Ku
AU - Mark Emery
AU - Mark Stolzenburg
AU - Peter McMurry
T1 - Measuring particle size-dependent physicochemical structure in airborne single walled carbon nanotube agglomerates.
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
Y1 - 2007/01/30/
VL - 9
IS - 1
M3 - Article
SP - 85
EP - 92
SN - 13880764
AB - Abstract??As-produced single-walled carbon nanotube (SWCNT) material is a complex matrix of carbon nanotubes, bundles of nanotubes (nanoropes), non-tubular carbon and metal catalyst nanoparticles. The pulmonary toxicity of material released during manufacture and handling will depend on the partitioning and arrangement of these components within airborne particles. To probe the physicochemical structure of airborne SWCNT aggregates, a new technique was developed and applied to aerosolized as-produced material. Differential Mobility Analysis-classified aggregates were analyzed using an Aerosol Particle Mass Monitor, and a structural parameter ? (proportional to the square of particle mobility diameter, divided by APM voltage) derived. Using information on the constituent components of the SWCNT, modal values of ? were estimated for specific particle compositions and structures, and compared against measured values. Measured modal values of ? for 150?nm mobility diameter aggregates suggested they were primarily composed of non-tubular carbon from one batch of material, and thin nanoropes from a second batch of material ? these findings were confirmed using Transmission Electron Microscopy. Measured modal values of ? for 31?nm mobility diameter aggregates indicated that they were comprised predominantly of thin carbon nanoropes with associated nanometer-diameter metal catalyst particles; there was no indication that either catalyst particles or non-tubular carbon particles were being preferentially released into the air. These results indicate that the physicochemistry of aerosol particles released while handling as-produced SWCNT may vary significantly by particle size and production batch, and that evaluations of potential health hazards need to account for this. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanoparticle Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLE size determination
KW - CARBON
KW - NANOTUBES
KW - AGGLOMERATION (Materials)
N1 - Accession Number: 23651087; Andrew Maynard 1 Bon Ku 2 Mark Emery 3 Mark Stolzenburg 3 Peter McMurry 3; Affiliation: 1: Project on Emerging Nanotechnologies Woodrow Wilson International Center for Scholars One Woodrow Wilson Plaza, 1300 Pennsylvania Avenue NW Washington DC 20004 USA One Woodrow Wilson Plaza, 1300 Pennsylvania Avenue NW Washington DC 20004 USA 2: National Institute for Occupational Safety and Health Centers for Disease Control and Prevention 4676 Columbia Parkway Cincinnati OH 45226 USA 4676 Columbia Parkway Cincinnati OH 45226 USA 3: University of Minnesota Mechanical Engineering Department 111 Church Street Minneapolis MN 55455 USA 111 Church Street Minneapolis MN 55455 USA; Source Info: Jan2007, Vol. 9 Issue 1, p85; Subject Term: PARTICLE size determination; Subject Term: CARBON; Subject Term: NANOTUBES; Subject Term: AGGLOMERATION (Materials); NAICS/Industry Codes: 212210 Iron Ore Mining; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Earl Lewis
AU - Gregory Glass
AU - Alexandre Dasilva
AU - Leena Tamang
AU - Autumn Girouard
AU - Frank Curriero
T1 - Quantitative assessment of viable Cryptosporidium parvum load in commercial oysters (Crassostrea virginica) in the Chesapeake Bay.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2007/01/30/
VL - 100
IS - 2
M3 - Article
SP - 247
EP - 253
SN - 09320113
AB - Abstract??The epidemiological importance of increasing reports worldwide onCryptosporidiumcontamination of oysters remains unknown in relation to foodborne cryptosporidiosis. Thirty market-size oysters (Crassostrea virginica), collected from each of 53 commercial harvesting sites in Chesapeake Bay, MD, were quantitatively tested in groups of six forCryptosporidiumsp. oocysts by immunofluorescent antibody (IFA). After IFA analysis, the samples were retrospectively retested for viableCryptosporidium parvumoocysts by combined fluorescent in situ hybridization (FISH) and IFA. The mean cumulative numbers ofCryptosporidiumsp. oocysts in six oysters (overall, 42.1?4.1) were significantly higher than in the numbers of viableC. parvumoocysts (overall, 28.0?2.9). Of 265 oyster groups, 221 (83.4%) contained viableC. parvumoocysts, and overall, from 10?32% (mean, 23%) of the total viable oocysts were identified in the hemolymph as distinct from gill washings. The amount of viableC. parvumoocysts was not related to oyster size or to the level of fecal coliforms at the sampling site. This study demonstrated that, although oysters are frequently contaminated with oocysts, the levels of viable oocysts may be too low to cause infection in healthy individuals. FISH assay for identification can be retrospectively applied to properly stored samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM parvum
KW - AMERICAN oyster
KW - CRYPTOSPORIDIUM
KW - CRASSOSTREA
N1 - Accession Number: 23698921; Earl Lewis 1 Gregory Glass 2 Alexandre Dasilva 3 Leena Tamang 4 Autumn Girouard 2 Frank Curriero 4; Affiliation: 1: Cooperative Oxford Laboratory National Oceanic and Atmospheric Administration, National Ocean Service Center for Coastal Environmental Health and Biomolecular Research Oxford MD 21654 USA Oxford MD 21654 USA 2: Johns Hopkins Bloomberg School of Public Health Department of Molecular Microbiology and Immunology Baltimore MD 21205 USA Baltimore MD 21205 USA 3: Centers for Disease Control and Prevention Public Health Service, U.S. Department of Health and Public Services, Division of Parasitic Diseases, National Center for Infectious Diseases Atlanta GA 30341 USA Atlanta GA 30341 USA 4: Johns Hopkins Bloomberg School of Public Health Department of Environmental Health Sciences, Division of Environmental Health Engineering Baltimore MD 21205 USA Baltimore MD 21205 USA; Source Info: Jan2007, Vol. 100 Issue 2, p247; Subject Term: CRYPTOSPORIDIUM parvum; Subject Term: AMERICAN oyster; Subject Term: CRYPTOSPORIDIUM; Subject Term: CRASSOSTREA; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tesfamariam, Belay
T1 - Local vascular toxicokinetics of stent-based drug delivery
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007/01/30/
VL - 168
IS - 2
M3 - Article
SP - 93
EP - 102
SN - 03784274
AB - Abstract: One of the major limitations of balloon angioplasty is early restenosis as a result of elastic recoil leading to vessel occlusion. The constrictive (negative) remodeling of the blood vessel is overcome by implanting a balloon expandible metal stent to dilate the artery and thereby prevent elastic recoil. However, bare metal stent implants cause mechanical injury to the intima and release of inflammatory mediators which then initiates formation of neointimal layer leading to restenosis. In-stent restenosis is histologically distinct from restenosis following balloon angioplasty, in which in-stent restenosis is accompanied by increased smooth muscle proliferation, migration, extracellular matrix and collagen synthesis leading to neointimal hyperplasia. To overcome neointimal hyperplasia, stents have been coated with pharmacological agents that inhibit smooth muscle cell proliferation and migration. The drug and polymer combination coated onto stent device is an efficient form of drug delivery system which can provide high concentrations of drug in the tissues over an extended period of time to achieve antiproliferative therapeutic effect. The permanent stent implants pose the risk of a continuous interaction between the non-biodegradable polymer coating and intimal surface leading to physical irritation, endothelial dysfunction, hypersensitivity reactions, delayed healing and excess risk of late stent thrombosis. This review highlights the relationship between local drug delivery using the stent platform, release kinetics and local vascular toxicity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transluminal angioplasty
KW - Angioplasty
KW - Coronary restenosis
KW - Hyperplasia
KW - Surgical stents
KW - Drug delivery
KW - Release kinetics
KW - Restenosis
KW - Stents
KW - Vascular toxicity
N1 - Accession Number: 23671629; Tesfamariam, Belay 1; Email Address: belay.tesfamariam@fda.hhs.gov; Affiliations: 1: Division of Cardiovascular and Renal, Center for Drug Evaluation and Research, FDA, Bldg 22, Rm 4176, 10903 New Hampshire Ave, Silver Spring, MD 20993-0002, USA; Issue Info: Jan2007, Vol. 168 Issue 2, p93; Subject Term: Transluminal angioplasty; Subject Term: Angioplasty; Subject Term: Coronary restenosis; Subject Term: Hyperplasia; Subject Term: Surgical stents; Author-Supplied Keyword: Drug delivery; Author-Supplied Keyword: Release kinetics; Author-Supplied Keyword: Restenosis; Author-Supplied Keyword: Stents; Author-Supplied Keyword: Vascular toxicity; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.11.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xia, Qingsu
AU - Yin, Jun Jie
AU - Fu, Peter P.
AU - Boudreau, Mary D.
T1 - Photo-irradiation of Aloe vera by UVA—Formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007/01/30/
VL - 168
IS - 2
M3 - Article
SP - 165
EP - 175
SN - 03784274
AB - Abstract: Aloe vera whole leaf extracts are incorporated into a wide variety of topically applied commercial products. Aloe vera whole leaf extracts may contain anthraquinones, which have been shown to generate reactive oxygen species in the presence of ultraviolet A (UVA) light. Exposure to UVA light alone can also generate reactive oxygen species and is associated with photo-damaged and photo-aged skin in humans. This paper examines the photochemical properties of two Aloe vera whole leaf extracts that differed in their anthraquinone content. In the presence of methyl linoleate, the UVA irradiation of Aloe vera leaf extracts induced lipid peroxidation. The amounts of lipid peroxides formed were higher in the Aloe vera leaf extract that contained lower amounts of anthraquinones. Superoxide dismutase and sodium azide inhibited and deuterium oxide enhanced the formation of lipid peroxides, suggesting that singlet oxygen and superoxide were involved in the mechanism. Spin trapping electron spin resonance (ESR) spectroscopy was used to investigate the generation of free radicals by the UVA photo-irradiated Aloe vera plant extracts. ESR measurements indicated that the UVA photo-irradiation of Aloe vera plant extracts produced carbon-centered free radicals. These results suggest that humans exposed to products that contain Aloe vera whole leaf extracts may have enhanced sensitivity to ultraviolet light. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ultraviolet radiation
KW - Aloe vera
KW - Anthraquinones
KW - Active oxygen
KW - Peroxidation
KW - ESR
KW - Lipid peroxidation
KW - Photo-irradiation
KW - Reactive oxygen species
KW - UVA
N1 - Accession Number: 23671637; Xia, Qingsu 1; Yin, Jun Jie 2; Fu, Peter P. 1; Boudreau, Mary D. 1; Email Address: Mboudreau@nctr.fda.gov; Affiliations: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Issue Info: Jan2007, Vol. 168 Issue 2, p165; Thesaurus Term: Ultraviolet radiation; Subject Term: Aloe vera; Subject Term: Anthraquinones; Subject Term: Active oxygen; Subject Term: Peroxidation; Author-Supplied Keyword: ESR; Author-Supplied Keyword: Lipid peroxidation; Author-Supplied Keyword: Photo-irradiation; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: UVA; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.11.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23671637&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Eduard Zaloshnja
AU - Ted R. Miller
AU - Delia Hendrie
AU - Deborah Galvin
T1 - Employer costs of alcohol‐involved injuriesThe findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the funding agency.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/02//
VL - 50
IS - 2
M3 - Article
SP - 136
EP - 142
SN - 02713586
AB - This study estimates the annual cost of alcohol‐related injuries to employers in 1998–2000.Incidence was estimated with occupational injury data, motor vehicle crash data and health care data for 1998–2000. Employer costs were estimated from federal estimates of injury costs by source of payment using data on the percentage of varied payment streams (e.g., health insurance, sick leave) paid by employers.The annual employer cost of alcohol‐related injuries to employees and their dependents exceed $28.6 billion. Out of this, $13.2 billion comes from job‐related, alcohol‐involved injuries. The annual employer cost of motor vehicle crashes in which at least one driver was alcohol‐impaired is over $9.2 billion. Out of this, only $3.4 billion comes from job‐related alcohol involvement.Safety programs can reduce the fringe benefit bill without reducing the benefits offered to employees. Am. J. Ind. Med. 2007. © 2006 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Alcoholism
KW - Personal injuries (Law)
KW - Employers' liability
KW - Alcoholics
N1 - Accession Number: 24512184; Eduard Zaloshnja 1; Ted R. Miller 1; Delia Hendrie 2; Deborah Galvin 3; Affiliations: 1: Pacific Institute for Research and Evaluation, Calverton, Maryland; 2: University of Western Australia, School of Population Health, Crawley, Western Australia; 3: Center for Substance Abuse Prevention, Division of Workplace Programs, Rockville, Maryland; Issue Info: Feb2007, Vol. 50 Issue 2, p136; Thesaurus Term: WOUNDS & injuries; Subject Term: Alcoholism; Subject Term: Personal injuries (Law); Subject Term: Employers' liability; Subject Term: Alcoholics; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kuo, Cassie
AU - Jamieson, Denise K.
AU - McPheeters, Melissa L.
AU - Meikle, Susan F.
AU - Posner, Samuel F.
T1 - Injury hospitalizations of pregnant women in the United States, 2002.
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2007/02//
VL - 196
IS - 2
M3 - Article
SP - 161
EP - 163
SN - 00029378
AB - The authors estimate the number of injury-related hospitalizations of pregnant women in the United States and identify injury mechanisms associated with hospitalizations that end in delivery. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANT women
KW - HOSPITAL care
KW - PREGNANCY complications
KW - OBSTETRICAL emergencies
KW - DELIVERY (Obstetrics)
KW - UNITED States
N1 - Accession Number: 24208040; Kuo, Cassie 1; Jamieson, Denise K. 2; McPheeters, Melissa L. 3; Meikle, Susan F. 4; Posner, Samuel F. 1; Source Information: Feb2007, Vol. 196 Issue 2, p161; Subject: PREGNANT women; Subject: HOSPITAL care; Subject: PREGNANCY complications; Subject: OBSTETRICAL emergencies; Subject: DELIVERY (Obstetrics); Geographic Terms: UNITED States; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1016/j.ajog.2006.09.015
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Myint, Maung S.
AU - Johnson, Yvette J.
AU - Paige, Joseph C.
AU - Bautista, Daniel A.
T1 - A cross-sectional study of bacterial contamination in plant-protein feed from feed stores in Northern Virginia and Maryland
JO - Animal Feed Science & Technology
JF - Animal Feed Science & Technology
Y1 - 2007/02//
VL - 133
IS - 1/2
M3 - Article
SP - 137
EP - 148
SN - 03778401
AB - Abstract: The objectives of this study were to estimate the prevalence of the enteric microbes: Escherichia coli, Salmonella, Campylobacter and Enterococcus spp., in plant-protein-based animal feed products and milk replacer and to identify risk factors associated with contamination by these bacteria. A cross-sectional survey of 158 plant-derived feed and milk replacer samples was conducted using eight animal feed stores in Northern Virginia and Maryland from January 2002 to September 2002. Overall, all samples were negative for Campylobacter; one sample (0.6%) was positive for Salmonella; nine samples (5.7%) were positive for E. coli and 80 samples (50.6%) were positive for Enterococcus. Positive samples included: whole maize, cracked peanut, cotton seed, mixed grain horse feed, and milk replacer. Samples collected during the month of January (winter) had a lower prevalence of contamination with enteric bacteria than samples collected in August and September (summer/autumn). Samples collected in January 2002 were negative for both E. coli and Salmonella. Samples collected in August and September 2002 included one Salmonella positive, and nine E. coli positive. Animal feed purchased during August and September had a 38-fold increase (95% CI: 15.60–95.16) in the risk of contamination by Enterococcus than those samples purchased during January and February of that same year (P<0.001). Enterococcus positive samples were eight times more likely to also be E. coli positive than Enterococcus negative samples (95% CI: 1.04–70.12). Non-pelleted feed was 13 times more likely to be contaminated with Enterococcus than pelleted feed (95% CI: 3.02–59.84). [Copyright &y& Elsevier]
AB - Copyright of Animal Feed Science & Technology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FEEDS
KW - ANIMAL feeding
KW - ESCHERICHIA coli
KW - FOOD poisoning
KW - UNITED States
KW - Animal feed
KW - Campylobacter
KW - E. coli
KW - Enteric bacteria
KW - Enterococcus
KW - Salmonella
N1 - Accession Number: 23447463; Myint, Maung S. 1 Johnson, Yvette J. 1; Email Address: yjjohn38@uiuc.edu Paige, Joseph C. 2 Bautista, Daniel A. 3; Affiliation: 1: Virginia-Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA 2: FDA-Center for Veterinary Medicine, 7519 Standish Place, Rockville, MD 20855, USA 3: Maryland Department of Agriculture, Diagnostic Laboratory, Nanticoke Road, Salisbury, MD 21801, USA; Source Info: Feb2007, Vol. 133 Issue 1/2, p137; Subject Term: FEEDS; Subject Term: ANIMAL feeding; Subject Term: ESCHERICHIA coli; Subject Term: FOOD poisoning; Subject Term: UNITED States; Author-Supplied Keyword: Animal feed; Author-Supplied Keyword: Campylobacter; Author-Supplied Keyword: E. coli; Author-Supplied Keyword: Enteric bacteria; Author-Supplied Keyword: Enterococcus; Author-Supplied Keyword: Salmonella; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.anifeedsci.2006.08.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, N. Beth
AU - Payeur, Janet
AU - Bravo, Doris
AU - Osorio, Ruben
AU - Stuber, Tod
AU - Farrell, David
AU - Paulson, Debra
AU - Treviso, Scarlett
AU - Mikolon, Andrea
AU - Rodriguez-Lainz, Alfonso
AU - Cernek-Hoskins, Shannon
AU - Rast, Robert
AU - Ginsberg, Michele
AU - Kinde, Hailu
T1 - Recovery of Mycobacterium bovis from Soft Fresh Cheese Originating in Mexico.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/02//
VL - 73
IS - 3
M3 - Article
SP - 1025
EP - 1028
SN - 00992240
AB - Recent outbreaks of human tuberculosis in the United States caused by Mycobacterium bovis have implicated cheese originating in Mexico as a source of these infections. A total of 203 samples of cheese originating in Mexico were cultured, and M. bovis was recovered from one specimen. Therefore, M. bovis can be recovered from cheese and may be a source of human infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIAL diseases
KW - BACTERIAL diseases
KW - CHEESE
KW - INFECTION
KW - LUNG diseases
KW - TUBERCULOSIS
KW - IMPORTS
KW - MEXICO
KW - UNITED States
N1 - Accession Number: 24089907; Harris, N. Beth 1; Email Address: Beth.N.Harris@aphis.usda.gov Payeur, Janet 1 Bravo, Doris 1 Osorio, Ruben 1 Stuber, Tod 1 Farrell, David 1 Paulson, Debra 2 Treviso, Scarlett 3 Mikolon, Andrea 3 Rodriguez-Lainz, Alfonso 4 Cernek-Hoskins, Shannon 4 Rast, Robert 5 Ginsberg, Michele 6,7 Kinde, Hailu 2; Affiliation: 1: National Veterinary Services Laboratories, Veterinaiy Services, Animal and Plant Health Inspection Services, United States Department of Agriculture, Ames, Iowa 50010 2: California Animal Health and Food Safety Laboratoty System, San Bernardino, California 92408 3: Animal Health and Food Safety Services, California Department of Food and Agriculture, Sacramento, California 95814 4: California Office of Binational Border Health, California Department of Health Services, San Diego, California 92110 5: Office of Regulatory Affairs, United States Food and Drug Administration, San Diego, California 92154 6: Department of Medicine, University of California San Diego, La Jolla, California 92093 7: Community Epidemiology Branch, Public Health Services, County of San Diego HHSA, San Diego, California 92101; Source Info: Feb2007, Vol. 73 Issue 3, p1025; Subject Term: MYCOBACTERIAL diseases; Subject Term: BACTERIAL diseases; Subject Term: CHEESE; Subject Term: INFECTION; Subject Term: LUNG diseases; Subject Term: TUBERCULOSIS; Subject Term: IMPORTS; Subject Term: MEXICO; Subject Term: UNITED States; NAICS/Industry Codes: 311513 Cheese Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1128/AEM.01956-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
T1 - Substitutions of amino acids in α-helix-4 of gyrase A confer fluoroquinolone resistance on Clostridium perfringens.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2007/02//
VL - 187
IS - 2
M3 - Article
SP - 137
EP - 144
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - DNA gyrase, an essential enzyme that regulates DNA topology in bacteria, is the target of fluoroquinolones. Three fluoroquinolone-resistant mutants derived from one strain of Clostridium perfringens had amino acid substitutions of glycine 81 to cysteine, aspartic acid 87 to tyrosine, or both, in α-helix-4 of gyrase A. The gyrase mutations affected the growth kinetics of mutants differently when the mutants were exposed to increasing concentrations of gatifloxacin and ciprofloxacin. Fluoroquinolone concentration-dependent effects observed during growth in the exponential and stationary phases depended on the presence of particular gyrA mutations. Introduction of a wild-type gyrA gene into the mutants enhanced their susceptibility to fluoroquinolones and decreased their growth rates proportional to increases in fluoroquinolone concentrations. Amino acid substitutions in α-helix-4 of gyrase A protected C. perfringens from fluoroquinolones, and a strain with two substitutions was the most resistant. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - Bacillaceae
KW - Amino acids
KW - Clostridium
KW - DNA
KW - Fluoroquinolones
KW - Gyrase A
KW - Mutations
KW - Resistance
N1 - Accession Number: 23827893; Rafii, Fatemeh 1; Email Address: Fatemeh.rafii@fda.hhs.gov; Park, Miseon 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, FDA, JeVerson, AR 72079, USA; Issue Info: Feb2007, Vol. 187 Issue 2, p137; Thesaurus Term: Nucleic acids; Thesaurus Term: Bacillaceae; Subject Term: Amino acids; Subject Term: Clostridium; Subject Term: DNA; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Gyrase A; Author-Supplied Keyword: Mutations; Author-Supplied Keyword: Resistance; Number of Pages: 8p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00203-006-0180-y
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Berentson-Shaw, Jessica
AU - Price, Kerry
T1 - Facilitating effective health promotion practice in a public health unit: lessons from the field.
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 2007/02//
VL - 31
IS - 1
M3 - Article
SP - 81
EP - 86
SN - 13260200
AB - Objectives: Health promotion is a core function of public health services and improving the effectiveness of health promotion services is an essential part of public health service development. This report describes the rationale, the process and the outcomes of a realignment designed to improve the effectiveness of health promotion activities in a public health unit (PHU) in New Zealand. Methods: A practice environment analysis revealed several factors that were hindering the effectiveness of the health promotion unit's (HPU) activities. Two primary change mechanisms were implemented. The first was an outcomes-focused model of planning and service delivery (to support evidenced-based practice), the second was the reorganization of the HPU from a topics-based structure to an integrated one based on a multi-risk factor paradigm of population health. Results: During the realignment barriers were encountered on multiple levels. At the individual level, unfavourable attitudes to changes occurred because of a lack of information and knowledge about the benefits of evidence and research. At higher levels, barriers included resourcing concerns, a lack of organisational commitment and understanding, and tensions between the political need for expedient change and research and development need for timely consideration of the impact of different models of practice. Conclusions and Implications: This realignment took place within the context of a changing public health environment, which is significantly altering the delivery of public health and health promotion. Realignments designed to facilitate more effective health promotion and public health practice will continue, but need to do so in the light of others' experience and debate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Australian & New Zealand Journal of Public Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - HUMAN services
KW - HEALTH promotion
KW - PREVENTIVE health services
KW - HEALTH education
KW - PUBLIC health
KW - PREVENTIVE medicine
KW - PATIENT education
KW - NEW Zealand
N1 - Accession Number: 24215797; Berentson-Shaw, Jessica 1; Email Address: jessicaberentson@gmail.com; Price, Kerry 1; Affiliations: 1: Auckland Regional Public Health Service, New Zealand; Issue Info: Feb2007, Vol. 31 Issue 1, p81; Thesaurus Term: MEDICAL care; Thesaurus Term: HUMAN services; Subject Term: HEALTH promotion; Subject Term: PREVENTIVE health services; Subject Term: HEALTH education; Subject Term: PUBLIC health; Subject Term: PREVENTIVE medicine; Subject Term: PATIENT education; Subject: NEW Zealand; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Pumbwe, L.
AU - Wareham, D. W.
AU - Aduse-Opoku, J.
AU - Brazier, J. S.
AU - Wexler, H. M.
T1 - Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis.
JO - Clinical Microbiology & Infection
JF - Clinical Microbiology & Infection
Y1 - 2007/02//
VL - 13
IS - 2
M3 - Article
SP - 183
EP - 189
PB - Elsevier Science
SN - 1198743X
AB - This study investigated the mechanisms of multidrug resistance (MDR) in an isolate of Bacteroides fragilis (WI1) from a patient with anaerobic sepsis. The MDR of WI1 affected susceptibility to β-lactams, clindamycin, fluoroquinolones, metronidazole and tetracycline. In addition to its 5.31-Mb chromosome, WI1 possessed two low-copy-number plasmids, pHagl (5.6 kb) and pHag2 (9.9 kb), that were absent from B. fragilis NCTC 9343. Restriction digestion with EcoRV, HindIII and SstI, combined with DNA sequencing, revealed that pHAG2 contained a tet(Q) gene at base position 3689 that resided on the conjugative transposon CTn 341. Genes cfiA (encoding a metallo-β-lactamase) and erm(F) (encoding a macrolide–lincosamide–streptogramin B resistance determinant) were also found in WI1, but were absent from B. fragilis NCTC 9343. Nitrocefin hydrolysis revealed that WI1 had high β-lactamase activity. Sequencing of the gyrA quinolone resistance-determining region revealed a mutation causing a Ser82→Phe substitution, and comparative quantitative real-time RT-PCR revealed that the cfiA, erm(F) and tet(Q) genes were all expressed in WI1. In addition, the resistance–nodulation–division efflux pump genes bmeB9 and bmeB15 were significantly over-expressed (12.30 ± 0.42-fold and 3541.1 ± 95.4-fold, respectively), and the efflux pump inhibitors carbonyl cyanide m-chlorophenylhydrazone and reserpine significantly increased the susceptibility of the isolate to several unrelated antibiotics (p <0.005). These data suggested that WI1 was highly multidrug-resistant because of the additive effects of chromosome- and plasmid-encoded resistance determinants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Microbiology & Infection is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Septicemia
KW - Genetics
KW - Antibiotics
KW - Drug resistance
KW - Bacteroides
KW - Bacteroides fragilis
KW - cross-resistance
KW - efflux pumps
KW - multidrug resistance
KW - plasmid
KW - susceptibility
N1 - Accession Number: 23659070; Pumbwe, L. 1,2; Wareham, D. W. 3; Aduse-Opoku, J. 4; Brazier, J. S. 5; Wexler, H. M. 1,2; Email Address: hwexler@ucla.edu; Affiliations: 1: Greater Los Angeles Veterans Administration Healthcare Systems; 2: Department of Medicine, University of California, Los Angeles, CA, USA; 3: Department of Microbiology, Barts and The London NHS Trust; 4: Centre for Infectious Disease, Institute of Cell and Molecular Science, Queen Mary's School of Medicine and Dentistry, University of London, London and; 5: Anaerobe Reference Laboratory, National Public Health Service Microbiology Cardiff, University Hospital of Wales, Cardiff, UK; Issue Info: Feb2007, Vol. 13 Issue 2, p183; Thesaurus Term: Septicemia; Thesaurus Term: Genetics; Thesaurus Term: Antibiotics; Subject Term: Drug resistance; Subject Term: Bacteroides; Author-Supplied Keyword: Bacteroides fragilis; Author-Supplied Keyword: cross-resistance; Author-Supplied Keyword: efflux pumps; Author-Supplied Keyword: multidrug resistance; Author-Supplied Keyword: plasmid; Author-Supplied Keyword: susceptibility; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1469-0691.2006.01620.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Liang Peng
AU - Shan Sun
T1 - Comparisons Between Local Linear Estimator and Kernel Smooth Estimator for a Smooth Distribution Based on MSE Under Right Censoring.
JO - Communications in Statistics: Theory & Methods
JF - Communications in Statistics: Theory & Methods
Y1 - 2007/02//
VL - 36
IS - 2
M3 - Article
SP - 297
EP - 312
SN - 03610926
AB - We propose a local linear estimator for a smooth distribution function based on censored data. This new estimator applies local linear techniques to observations from a regression model where the value of the product limit estimator equals the value of the true distribution plus an error term. We show that the advantage of using the local linear estimator over the smooth kernel estimator is that, for most commonly used kernel functions, local linear estimator has a smaller mean squared error than the kernel smooth estimator studied by Ghorai and Susarla (1990). [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications in Statistics: Theory & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - LINEAR models (Statistics)
KW - REGRESSION analysis
KW - RANDOM variables
KW - MATHEMATICAL analysis
KW - KERNEL functions
KW - Censored data
KW - Distribution function
KW - Local linear estimation
KW - MSE
KW - Product-limit estimator
N1 - Accession Number: 24196039; Liang Peng 1; Email Address: peng@math.gatech.edu; Shan Sun 2; Affiliations: 1: School of Mathematics, Georgia Institute of Technology, Atlanta, Georgia, USA; 2: Texas Tech University and Food and Drug Administration, Center for Drug Evaluation and Research, Lubbock, Texas, USA; Issue Info: Feb2007, Vol. 36 Issue 2, p297; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: REGRESSION analysis; Thesaurus Term: RANDOM variables; Thesaurus Term: MATHEMATICAL analysis; Subject Term: KERNEL functions; Author-Supplied Keyword: Censored data; Author-Supplied Keyword: Distribution function; Author-Supplied Keyword: Local linear estimation; Author-Supplied Keyword: MSE; Author-Supplied Keyword: Product-limit estimator; Number of Pages: 16p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/03610920600974351
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Su, Zhenqiang
AU - Hong, Huixiao
AU - Perkins, Roger
AU - Shao, Xueguang
AU - Cai, Wensheng
AU - Tong, Weida
T1 - Consensus analysis of multiple classifiers using non-repetitive variables: Diagnostic application to microarray gene expression data
JO - Computational Biology & Chemistry
JF - Computational Biology & Chemistry
Y1 - 2007/02//
VL - 31
IS - 1
M3 - Article
SP - 48
EP - 56
SN - 14769271
AB - Abstract: Class prediction based on DNA microarray data has been emerged as one of the most important application of bioinformatics for diagnostics/prognostics. Robust classifiers are needed that use most biologically relevant genes embedded in the data. A consensus approach that combines multiple classifiers has attributes that mitigate this difficulty compared to a single classifier. A new classification method named as consensus analysis of multiple classifiers using non-repetitive variables (CAMCUN) was proposed for the analysis of hyper-dimensional gene expression data. The CAMCUN method combined multiple classifiers, each of which was built from distinct, non-repeated genes that were selected for effectiveness in class differentiation. Thus, the CAMCUN utilized most biologically relevant genes in the final classifier. The CAMCUN algorithm was demonstrated to give consistently more accurate predictions for two well-known datasets for prostate cancer and leukemia. Importantly, the CAMCUN algorithm employed an integrated 10-fold cross-validation and randomization test to assess the degree of confidence of the predictions for unknown samples. [Copyright &y& Elsevier]
AB - Copyright of Computational Biology & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - HEREDITY
KW - NUCLEIC acids
KW - BIOINFORMATICS
KW - Consensus approach
KW - Diagnostics
KW - Microarray gene expression
KW - Prognostics
N1 - Accession Number: 24085571; Su, Zhenqiang 1,2 Hong, Huixiao 3 Perkins, Roger 3 Shao, Xueguang 4 Cai, Wensheng 1,4; Email Address: wscai@ustc.edu.cn Tong, Weida 2; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China 2: Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), 3900 NCTR Road, HFT 020, Jefferson, AR 72079, USA 3: Division of Bioinformatics, Z-Tech at FDA's National Center for Toxicological Research, Jefferson, AR 72079, USA 4: Department of Chemistry, Nankai University, Tianjin 300071, China; Source Info: Feb2007, Vol. 31 Issue 1, p48; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: NUCLEIC acids; Subject Term: BIOINFORMATICS; Author-Supplied Keyword: Consensus approach; Author-Supplied Keyword: Diagnostics; Author-Supplied Keyword: Microarray gene expression; Author-Supplied Keyword: Prognostics; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.compbiolchem.2007.01.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cotter, Peggy A
AU - Stibitz, Scott
T1 - c-di-GMP-mediated regulation of virulence and biofilm formation
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
Y1 - 2007/02//
VL - 10
IS - 1
M3 - Article
SP - 17
EP - 23
SN - 13695274
AB - It is now apparent that the signaling molecule 3′,5′-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing proteins) that are responsible for synthesis and degradation of c-di-GMP have recently been identified. Members of the phosphorelay family feature prominently amongst these systems, which include several with hybrid polydomain sensors and one that is similar to well-characterized chemotaxis-controlling pathways. These findings support the hypothesis that c-di-GMP levels are tightly controlled in response to a broad range, in terms of both diversity and intensity, of extracellular signals. Insight into how c-di-GMP affects changes in gene expression and/or protein activity has come from the demonstration that proteins containing the PilZ domain can bind c-di-GMP and control phenotypes involved in biofilm formation and virulence. These recent developments should pave the way for researchers to answer the important question of how a vast array of extracellular signals that are sensed by multiple sensory transduction pathways which all lead to the production or destruction of c-di-GMP are coordinated such that the appropriate phenotypic response is produced. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRULENCE (Microbiology)
KW - PROKARYOTES
KW - PATHOGENIC microorganisms
KW - MICROBIAL genetics
KW - GENE expression
KW - PHENOTYPE
N1 - Accession Number: 23950023; Cotter, Peggy A 1; Email Address: cotter@lifesci.ucsb.edu Stibitz, Scott 2; Affiliation: 1: Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106-9610, USA 2: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Feb2007, Vol. 10 Issue 1, p17; Subject Term: VIRULENCE (Microbiology); Subject Term: PROKARYOTES; Subject Term: PATHOGENIC microorganisms; Subject Term: MICROBIAL genetics; Subject Term: GENE expression; Subject Term: PHENOTYPE; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mib.2006.12.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kraeling, Margaret E. K.
AU - Bronaugh, Robert L.
AU - Jung, Connie T.
T1 - Absorption of Lawsone Through Human Skin.
JO - Cutaneous & Ocular Toxicology
JF - Cutaneous & Ocular Toxicology
Y1 - 2007/02//
VL - 26
IS - 1
M3 - Article
SP - 45
EP - 56
PB - Taylor & Francis Ltd
SN - 15569527
AB - Lawsone (2-hydroxy-1,4-naphthoquinone) is the principal color ingredient in henna, a color additive approved with limitations for coloring hair by the Food and Drug Administration (FDA) under 21 CFR 73.2190. In 2002, the scientific committee on cosmetics and non-food products (SCCNFP), now known as the scientific committee for consumer products (SCCP), evaluated the safety of lawsone as a coloring agent in hair dye products of the European Union (EU). The SCCNFP concluded that lawsone was mutagenic and not suitable for use as a hair coloring agent. As a result, studies were conducted to measure the extent of lawsone absorption through human skin. Lawsone skin absorption was determined from two hair coloring products and two shampoo products, all containing henna. [14C]-Lawsone (sp. act. 22.9 mCi/mmol) was added to each commercial product and the products were applied to dermatomed, nonviable human skin mounted in flow-through diffusion cells perfused with a physiological buffer (HEPES-buffered Hanks' balanced salt solution, pH 7.4). Products remained on the skin for 5 minutes (shampoos) and 1 hour (hair color paste). For the henna hair paste products, 0.3 and 1.3% of the applied dose was absorbed into the receptor fluid in 24 hours while 2.2 and 4.0% remained in the skin. For both henna shampoo products, 0.3% of the applied dose was absorbed into the receptor fluid at 24 hours while 3.6 and 6.8% remained in the skin. For all products, most of the lawsone applied was washed from the surface of the skin (83-102%) at the end of the exposure period. Extended absorption studies were conducted for 72 hours to determine if skin levels of lawsone in the 24 hour studies might eventually be percutaneously absorbed. These studies determined that the majority of the lawsone remained in the skin with only a small but significant increase (for three out of four products) in receptor fluid values. Therefore, it appears that receptor fluid values would give a good estimate of lawsone absorption for an exposure estimate and that skin levels of lawsone need not be included. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Skin absorption
KW - Absorption (Physiology)
KW - Hair -- Dyeing & bleaching
KW - Henna (Dye)
KW - Skin
KW - Cosmetics
KW - Human skin
KW - Lawsone
KW - Percutaneous absorption
N1 - Accession Number: 24903781; Kraeling, Margaret E. K. 1; Email Address: margaret.kraeling@fda.hhs.gov; Bronaugh, Robert L. 1; Jung, Connie T. 2; Affiliations: 1: Office of Cosmetics and Colors, US Food and Drug Administration. College Park, MD; 2: Office of the Commissioner, Office of Policy, US Food and Drug Administration. Rockville, MD; Issue Info: 2007, Vol. 26 Issue 1, p45; Subject Term: Skin absorption; Subject Term: Absorption (Physiology); Subject Term: Hair -- Dyeing & bleaching; Subject Term: Henna (Dye); Subject Term: Skin; Subject Term: Cosmetics; Author-Supplied Keyword: Human skin; Author-Supplied Keyword: Lawsone; Author-Supplied Keyword: Percutaneous absorption; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 12p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15569520601183856
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - De Zwart, Onno
AU - Veldhuijzen, Irene K.
AU - Elam, Gillian
AU - Aro, Arja R.
AU - Abraham, Thomas
AU - Bishop, George D.
AU - Richardus, Jan Hendrik
AU - Brug, Johannes
T1 - Avian Influenza Risk Perception, Europe and Asia.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/02//
VL - 13
IS - 2
M3 - Article
SP - 290
EP - 293
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - During autumn 2005, we conducted 3,436 interviews in European and Asian countries. We found risk perceptions of avian influenza to be at an intermediate level and beliefs of efficacy to be slightly lower. Risk perceptions were higher in Asia than Europe; efficacy beliefs were lower in Europe than in Asia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Avian influenza
KW - Risk perception
KW - Self-efficacy
KW - Europe
KW - Asia
N1 - Accession Number: 23887194; De Zwart, Onno 1; Email Address: dezwarto@ggd.rotterdam.nl; Veldhuijzen, Irene K. 1; Elam, Gillian 2; Aro, Arja R. 3; Abraham, Thomas 4; Bishop, George D. 5; Richardus, Jan Hendrik 6; Brug, Johannes 6; Affiliations: 1: Municipal Public Health Service, Rotterdam, the Netherlands; 2: Health Protection Agency-Centre for Infections, London, United Kingdom; 3: University of Southern Denmark, Esbjerg, Denmark; 4: University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China; 5: National University of Singapore, Singapore; 6: Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands; Issue Info: Feb2007, Vol. 13 Issue 2, p290; Thesaurus Term: Avian influenza; Subject Term: Risk perception; Subject Term: Self-efficacy; Subject: Europe; Subject: Asia; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Demchuk, Eugene
AU - Yucesoy, Berran
AU - Johnson, Victor J.
AU - Andrew, Michael
AU - Weston, Ainsley
AU - Germolec, Dori R.
AU - De Rosa, Christopher T.
AU - Luster, Michael I.
T1 - A Statistical Model for Assessing Genetic Susceptibility as a Risk Factor in Multifactorial Diseases: Lessons from Occupational Asthma.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/02//
VL - 115
IS - 2
M3 - Article
SP - 231
EP - 234
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. OBJECTIVE: The purpose of this study was to estimate the combinatorial contribution of multiple genetic variants to disease risk. METHODS: We used a logistic regression model to help estimate the joint contribution that multiple genetic variants would have on disease risk. This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. RESULTS: Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. Our model predicts that multiple disease variants broaden the risk distribution, facilitating the identification of susceptible populations. This model also allows for incorporation of exposure information as an independent variable, which will be important for risk variants associated with specific exposures. CONCLUSION: The present model provided an opportunity to estimate the relative change in risk associated with multiple genetic variants. This will facilitate identification of susceptible populations and help provide a framework to model the genetic contribution in probabilistic risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Epidemiology
KW - Heredity
KW - Mathematical models
KW - Industrial hygiene
KW - Regression analysis
KW - Work environment -- Environmental aspects
KW - Genetic polymorphisms
KW - asthma
KW - genetics
KW - polygenic diseases
KW - risk assessment
KW - susceptibility genes
N1 - Accession Number: 24222566; Demchuk, Eugene 1,2; Yucesoy, Berran 2; Email Address: byucesoy@cdc.gov; Johnson, Victor J. 2; Andrew, Michael 3; Weston, Ainsley 2; Germolec, Dori R. 4; De Rosa, Christopher T. 1; Luster, Michael I. 2; Affiliations: 1: Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 2: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 3: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 4: Toxicology Operations Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; Issue Info: Feb2007, Vol. 115 Issue 2, p231; Thesaurus Term: Asthma; Thesaurus Term: Epidemiology; Thesaurus Term: Heredity; Thesaurus Term: Mathematical models; Thesaurus Term: Industrial hygiene; Subject Term: Regression analysis; Subject Term: Work environment -- Environmental aspects; Subject Term: Genetic polymorphisms; Author-Supplied Keyword: asthma; Author-Supplied Keyword: genetics; Author-Supplied Keyword: polygenic diseases; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: susceptibility genes; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Herbert, Robin
AU - Skloot, Gwen
AU - Metzger, Kristina
AU - Landrigan, Philip J.
AU - Moline, Jacqueline
AU - Stein, Diane
AU - Todd, Andrew
AU - Levin, Stephen M.
AU - Baron, Sherry
AU - Udasin, Iris
T1 - WTC Five-Year Assessment: Herbert et al. Respond.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/02//
VL - 115
IS - 2
M3 - Letter
SP - A72
EP - A73
PB - Superintendent of Documents
SN - 00916765
AB - A response by Herbert et al to a letter to the editor about their article “The World Trade Center disaster and the health of workers: five-year assessment of a unique medical screening program,” which appeared in the Vol. 114, 2006 issue.
KW - Letters to the editor
KW - September 11 Terrorist Attacks, 2001
N1 - Accession Number: 24222591; Herbert, Robin 1; Email Address: robin.herbert@mssm.edu; Skloot, Gwen 1; Metzger, Kristina 1; Landrigan, Philip J. 1; Moline, Jacqueline 1; Stein, Diane 1; Todd, Andrew 1; Levin, Stephen M. 1; Baron, Sherry 2; Udasin, Iris 3; Affiliations: 1: Mount Sinai School of Medicine, New York, New York; 2: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 3: Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey; Issue Info: Feb2007, Vol. 115 Issue 2, pA72; Subject Term: Letters to the editor; Subject Term: September 11 Terrorist Attacks, 2001; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Noll, I. D.
AU - Bugarski, A. D.
AU - Patts, L. D.
AU - Mischler, S. E.
AU - L. McWilliams
T1 - Relationship between Elemental Carbon, Total Carbon, and Diesel Particulate Matter in Several Underground Metal/Non-metal Mines.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2007/02//2/1/2007
VL - 41
IS - 3
M3 - Article
SP - 710
EP - 716
SN - 0013936X
AB - Elemental carbon (EC) is currently used as a surrogate for diesel particulate matter (DPM) in underground mines since it can be accurately measured at low concentrations and diesels are the only source of submicrometer EC in underground mines. A disadvantage of using EC as a surrogate for DPM is that the fraction of EC in DPM is a function of various engine parameters and fuel formulations, etc. In order to evaluate how EC predicts DPM in the underground mining atmosphere, measurements of total carbon (IC; representing over 80% of the DPM) and EC were taken away from potential interferences in four underground metal/non-metal mines during actual production. In a controlled atmosphere, DPM mass, IC, and EC measurements were also collected while several different types of vehicles simulated production with and without different types of control technologies. When diesel particulate filters (DPEs) were not used, both studies showed that EC could be used to predict DPM mass or IC. The variability of the data started to increase at IC concentrations below 230 μg/m³ and was high (>±20%) at TC concentrations below 160 μg/m³, probably due to the problem with sampling organic carbon (OC) at these concentrations. It was also discovered that when certain DPFs were used, the relationship between DPM and EC changed at lower DPM concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carbon
KW - Mines & mineral resources
KW - Diesel motor exhaust gas
KW - Emission control
KW - Engines
KW - Diesel motors
KW - Microbalances
KW - Regression analysis
KW - Multivariate analysis
N1 - Accession Number: 23993133; Noll, I. D. 1; Email Address: JINl@cdc.gov; Bugarski, A. D. 1; Patts, L. D. 1; Mischler, S. E. 1; L. McWilliams 1; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laborato,y, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236; Issue Info: 2/1/2007, Vol. 41 Issue 3, p710; Thesaurus Term: Carbon; Thesaurus Term: Mines & mineral resources; Thesaurus Term: Diesel motor exhaust gas; Thesaurus Term: Emission control; Thesaurus Term: Engines; Subject Term: Diesel motors; Subject Term: Microbalances; Subject Term: Regression analysis; Subject Term: Multivariate analysis; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - C. P. HUMPHREYS
AU - S. J. MORGAN
AU - M. WALAPU
AU - G. A. J. HARRISON
AU - A. P. KEEN
AU - A. EFSTRATIOU
AU - S. E. NEAL
AU - R. L. SALMON
T1 - Group A streptococcal skin infection outbreak in an abattoir: lessons for prevention.
JO - Epidemiology & Infection
JF - Epidemiology & Infection
Y1 - 2007/02//
VL - 135
IS - 2
M3 - Article
SP - 321
EP - 327
SN - 09502688
AB - During a group A streptococcus (GAS) outbreak 21 abattoir workers developed skin infections. The unusual outbreak strain (emm 108.1) was cultured from five workers and four persons in the community with links to the abattoir. The attack rate was 26% in the lamb line. Communal nailbrushes were neither routinely disinfected nor changed, and had high bacterial counts. A cohort study found a higher risk from working in the gutting area and getting cuts on hands more than weekly. Despite high bacterial counts daily nailbrush use had a lower risk, as did always wearing disposable gloves. Working in the gutting area (OR 11·44) and nailbrush use at least once a day (OR 0·04) were significant in the multivariate model. Transmission of infection is likely to have occurred on carcasses. GAS infection among abattoir workers was once common. Simple hygiene measures, such as nailbrush use, may reduce the impact of future outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Epidemiology & Infection is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Communicable diseases -- Transmission
KW - Slaughtering & slaughterhouses
KW - Streptococcus
KW - Skin -- Infections
KW - Hygiene
N1 - Accession Number: 23969960; C. P. HUMPHREYS 1; S. J. MORGAN 1; M. WALAPU 1; G. A. J. HARRISON 2; A. P. KEEN 2; A. EFSTRATIOU 3; S. E. NEAL 4; R. L. SALMON 5; Affiliations: 1: National Public Health Service for Wales, Mid and West Wales, Carmarthen, UK; 2: National Public Health Service for Wales Microbiology, Carmarthen, UK; 3: Streptococcus and Diphtheria Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency, Centre for Infections, London, UK; 4: Respiratory and Systemic Infection Laboratory, Health Protection Agency, Centre for Infections, London, UK; 5: National Public Health Service for Wales, Communicable Disease Surveillance Centre, Cardiff, UK; Issue Info: Feb2007, Vol. 135 Issue 2, p321; Thesaurus Term: Epidemics; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Slaughtering & slaughterhouses; Subject Term: Streptococcus; Subject Term: Skin -- Infections; Subject Term: Hygiene; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106194804
T1 - Group A streptococcal skin infection outbreak in an abattoir: lessons for prevention.
AU - Humphreys CP
AU - Morgan SJ
AU - Walapu M
AU - Harrison GAJ
AU - Keen AP
AU - Efstratiou A
AU - Neal SE
AU - Salmon RL
Y1 - 2007/02//
N1 - Accession Number: 106194804. Language: English. Entry Date: 20071123. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Disease Outbreaks
KW - Occupational Exposure
KW - Skin Diseases -- Risk Factors
KW - Streptococcal Infections -- Risk Factors
KW - Adult
KW - Chi Square Test
KW - Confidence Intervals
KW - Gloves
KW - Hygiene
KW - Interviews
KW - Meat
KW - Multivariate Analysis
KW - Occupational Hazards
KW - Odds Ratio
KW - Questionnaires
KW - Relative Risk
KW - Skin Diseases -- Prevention and Control
KW - Step-Wise Multiple Regression
KW - Streptococcal Infections -- Prevention and Control
KW - Telephone
KW - Wales
KW - Human
SP - 321
EP - 327
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 135
IS - 2
PB - Cambridge University Press
AB - During a group A streptococcus (GAS) outbreak 21 abattoir workers developed skin infections. The unusual outbreak strain (emm 108.1) was cultured from five workers and four persons in the community with links to the abattoir. The attack rate was 26% in the lamb line. Communal nailbrushes were neither routinely disinfected nor changed, and had high bacterial counts. A cohort study found a higher risk from working in the gutting area and getting cuts on hands more than weekly. Despite high bacterial counts daily nailbrush use had a lower risk, as did always wearing disposable gloves. Working in the gutting area (OR 11.44) and nailbrush use at least once a day (OR 0.04) were significant in the multivariate model. Transmission of infection is likely to have occurred on carcasses. GAS infection among abattoir workers was once common. Simple hygiene measures, such as nailbrush use, may reduce the impact of future outbreaks.
SN - 0950-2688
AD - National Public Health Service for Wales, Mid and West Wales, Carmarthen, UK.
U2 - PMID: 17291367.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106194804&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhong-Hua Liu
AU - Ikemoto, Satoshi
T1 - The midbrain raphe nuclei mediate primary reinforcement via GABAA receptors.
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
Y1 - 2007/02//
VL - 25
IS - 3
M3 - Article
SP - 735
EP - 743
PB - Wiley-Blackwell
SN - 0953816X
AB - Because rats learn to lever-press for brief electrical stimulation of the median and dorsal raphe nuclei (MRN and DRN, respectively), these brain sites have long been implicated in reward processes. However, it is not clear whether the MRN and DRN integrate reward-related signals or merely contain fibers of passage involved in reward processes. To shed light on this issue, the present study employed chemicals that selectively modulate neurotransmission, in particular the GABAA receptor agonist muscimol. Rats quickly learned to lever-press for muscimol infusions (50 and 100 µm) into the MRN or DRN. Muscimol was not self-administered when cannulae were placed just outside these nuclei. The reinforcing effects of muscimol appeared to be greater when the drug was administered into the MRN than into the DRN, as demonstrated by higher infusion rates and better response discrimination. These observations are consistent with the additional finding that muscimol administration into the MRN, but not the DRN, induced conditioned place preference. The reinforcing effects of muscimol administration into the MRN were blocked by coadministration of the GABAA antagonist picrotoxin (100 µm) and by pretreatment with the dopamine receptor antagonist SCH 23390 (0.025 mg/kg, i.p.). The present results suggest that median and dorsal raphe neurons presumably inhibited by muscimol via GABAA receptors are involved in integration of primary reinforcement, and that median raphe neurons exert tonic inhibition over dopamine-dependent reward circuitry. The midbrain raphe nuclei may be involved in a variety of reward-related phenomena including drug addiction. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSCUTANEOUS electrical nerve stimulation
KW - MESENCEPHALON
KW - GABA receptors
KW - VESTIBULAR nuclei
KW - NEUROSCIENCES
KW - conditioned place preference
KW - intracranial self-administration
KW - muscimol
KW - rat
KW - reward
N1 - Accession Number: 24006408; Zhong-Hua Liu 1 Ikemoto, Satoshi 1; Email Address: sikemoto@intra.nida.nih.gov; Affiliation: 1: Behavioural Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland, USA; Source Info: Feb2007, Vol. 25 Issue 3, p735; Subject Term: TRANSCUTANEOUS electrical nerve stimulation; Subject Term: MESENCEPHALON; Subject Term: GABA receptors; Subject Term: VESTIBULAR nuclei; Subject Term: NEUROSCIENCES; Author-Supplied Keyword: conditioned place preference; Author-Supplied Keyword: intracranial self-administration; Author-Supplied Keyword: muscimol; Author-Supplied Keyword: rat; Author-Supplied Keyword: reward; Number of Pages: 9p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1460-9568.2007.05319.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24006408&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yu, Hai-Ning
AU - Shen, Sheng-Rong
AU - Yin, Jun-Jie
T1 - Effects of interactions of EGCG and Cd2+ on the growth of PC-3 cells and their mechanisms
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2007/02//
VL - 45
IS - 2
M3 - Article
SP - 244
EP - 249
SN - 02786915
AB - Abstract: The preventive and therapeutic effects of a major component of catechins of green tea, epigallocatechin-3-gallate (EGCG), on prostate cancer have been demonstrated in many studies. It is well known that metal ions are necessary for human health, but an imbalance in metal ions metabolism can lead to many diseases including prostate cancer. Understanding the interactions of EGCG with metal ions might elucidate its mechanism in preventing and curing prostate cancer. The present study focused on the effects of Cd2+ and EGCG on the growth of androgen-insensitive prostate cancer cell PC-3 investigated by MTT assay, the effects of EGCG and Cd2+ on absorption of Cd2+ and Zn2+ by PC-3 cells were detected by atomic absorption spectroscopy (AAS), and the interactions of EGCG with Cd2+ were determined by distribution coefficient and UV–Vis spectroscopy detection. The results showed that Cd2+ suppressed viability of PC-3 cells in concentration- and time-dependent manner, and EGCG enhanced the effect of Cd2+ on PC-3 cells. EGCG was shown to decrease the absorption Cd2+ and increase the absorption of Zn2+ by PC-3 cells, while the effects of Cd2+ on the absorption of Cd2+ and Zn2+ were opposite to that of EGCG. In the presence of both EGCG and Cd2+, absorption of Cd2+ and Zn2+ by PC-3 cells was dependent on concentrations of EGCG, Cd2+ and its order of addition. Results from the distribution coefficient determination and UV–Vis spectroscopy analysis indicated that Cd2+ might affect conformation of EGCG, while no complex of EGCG with Cd2+ was observed in the system. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATECHIN
KW - GREEN tea
KW - PROSTATE cancer
KW - METAL ions
KW - CANCER prevention
KW - CANCER treatment
KW - ATOMIC absorption spectroscopy
KW - THERAPEUTIC use
KW - Cd2+
KW - EGCG
KW - Prostate cancer
KW - Zn2+
N1 - Accession Number: 23352979; Yu, Hai-Ning 1 Shen, Sheng-Rong 2; Email Address: shrshen@zju.edu.cn Yin, Jun-Jie 3; Affiliation: 1: College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310032, PR China 2: Department of Tea Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, PR China 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Source Info: Feb2007, Vol. 45 Issue 2, p244; Subject Term: CATECHIN; Subject Term: GREEN tea; Subject Term: PROSTATE cancer; Subject Term: METAL ions; Subject Term: CANCER prevention; Subject Term: CANCER treatment; Subject Term: ATOMIC absorption spectroscopy; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Cd2+; Author-Supplied Keyword: EGCG; Author-Supplied Keyword: Prostate cancer; Author-Supplied Keyword: Zn2+; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fct.2006.08.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23352979&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, H. J.
AU - Jeong, H. K.
AU - Chang, M. I.
AU - Im, M. H.
AU - Jeong, J. Y.
AU - Choi, D. M.
AU - Park, K.
AU - Hong, M. K.
AU - Youm, J.
AU - Han, S. B.
AU - Kim, D. J.
AU - Park, J. H.
AU - Kwon, S. W.
T1 - Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2007/02//
VL - 24
IS - 2
M3 - Article
SP - 122
EP - 129
PB - Taylor & Francis Ltd
SN - 0265203X
AB - New analogues of vardenafil and sildenafil illegally added to dietary supplements were detected by high-performance liquid chromatography (HPLC) analysis with a photodiode array detector (PDA). These compounds were isolated and their structures elucidated by mass spectrometry (MS), infrared (IR) spectroscopy, one- and two-dimensional nuclear magnetic resonance (NMR). One of the new analogues given the trivial name pseudovardenafil (compound 1) was structurally elucidated and shown to be 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-piperidine. It was a vardenafil analogue isolated from a dietary supplement capsule. Compared with vardenafil, the piperidine ring was substituted for the ethylpiperazine group. The second new analogue, trivially named hydroxyhongdenafil (compound 2), was separated from bulk powder used as a raw material for a dietary supplement. The piperazine and phenyl groups were connected through an acetyl group instead of a sulfonyl group, and hydroxyethylpiperazine was substituted for the methylpiperazine of sildenafil. It was structurally elucidated as 5-[2-ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]acetyl]phenyl]-1,4-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mass spectrometry
KW - Infrared spectroscopy
KW - Spectrum analysis
KW - Magnetic fields
KW - Optical spectroscopy
KW - Nuclear magnetic resonance
KW - Magnetic resonance
KW - Sildenafil
KW - Cyclic nucleotide phosphodiesterases -- Inhibitors
KW - hydroxyhongdenafil
KW - infrared (IR) spectroscopy
KW - Mass spectrometry (MS)
KW - nuclear magnetic resonance (NMR)
KW - pseudovardenafil
KW - sildenafil
KW - vardenafil
N1 - Accession Number: 24925062; Park, H. J. 1; Jeong, H. K. 1; Chang, M. I. 2; Im, M. H. 2; Jeong, J. Y. 2; Choi, D. M. 2; Park, K. 2; Hong, M. K. 2; Youm, J. 3; Han, S. B. 3; Kim, D. J. 1; Park, J. H. 1; Kwon, S. W. 1; Email Address: swkwon@snu.ac.kr; Affiliations: 1: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 151-742, Korea; 2: Korea Food and Drug Administration, Seoul, 122-704, Korea; 3: College of Pharmacy, Chung-Ang University, Seoul, 156-756, Korea; Issue Info: Feb2007, Vol. 24 Issue 2, p122; Thesaurus Term: Mass spectrometry; Thesaurus Term: Infrared spectroscopy; Thesaurus Term: Spectrum analysis; Thesaurus Term: Magnetic fields; Subject Term: Optical spectroscopy; Subject Term: Nuclear magnetic resonance; Subject Term: Magnetic resonance; Subject Term: Sildenafil; Subject Term: Cyclic nucleotide phosphodiesterases -- Inhibitors; Author-Supplied Keyword: hydroxyhongdenafil; Author-Supplied Keyword: infrared (IR) spectroscopy; Author-Supplied Keyword: Mass spectrometry (MS); Author-Supplied Keyword: nuclear magnetic resonance (NMR); Author-Supplied Keyword: pseudovardenafil; Author-Supplied Keyword: sildenafil; Author-Supplied Keyword: vardenafil; Number of Pages: 8p; Illustrations: 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/02652030600983625
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24925062&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Villareal, T.A.
AU - Hanson, S.
AU - Qualia, Steve
AU - Jester, E.L.E.
AU - Granade, H.R.
AU - Dickey, R.W.
T1 - Petroleum production platforms as sites for the expansion of ciguatera in the northwestern Gulf of Mexico
JO - Harmful Algae
JF - Harmful Algae
Y1 - 2007/02//
VL - 6
IS - 2
M3 - Article
SP - 253
EP - 259
SN - 15689883
AB - Abstract: Ciguatera is a common human disease of tropical, coral reef ecosystems acquired by consuming finfish-containing ciguatoxins (CTX). There are few records of this disease in the northwestern Gulf of Mexico, a region characterized by soft muddy bottoms that are considered poor habitat for the CTX source dinoflagellate Gambierdiscus toxicus. However, the approximately 4000 petroleum production platforms and hundreds of state-sponsored artificial reefs located in the Gulf of Mexico provide hard substrate and often support coral and other components of the tropical benthos. In addition to their role in their resource extraction, these oil production platforms are also popular sites for recreational fishing and sport diving. We examined these platforms as potential substrate for G. toxicus and report a first record of this species in the NW Gulf of Mexico. All the platforms (n =6) examined harbored the dinoflagellate as an epiphyte on the fouling community, with three finds of G. toxicus associated with the pelagic macroalga Sargassum. Only minor toxicity (<0.15ppb) was noted in two of 20 great barracuda (Sphyraena barracuda) examined. Tagging data suggest trans-Gulf migrations by barracuda are common; thus, we cannot determine if the toxicity was acquired locally or transported in migrating fish. These platforms are a clear example of how human activity has altered the environment in a way that allows expansion of a HAB population. The rapid increase in production platforms since 1942 has provided novel substrate in a sandy/muddy bottom environment generally considered to be poor habitat for these benthic dinoflagellates. These platforms create a unique habitat in the upper euphotic zone and serve as intersection points for fishermen and potentially toxic fish. Many Gulf of Mexico states have active programs to turn non-producing platforms into artificial reefs. Our results suggest that the use of these platforms as fisheries enhancement structures could have unintended consequences for human health, particularly if projected rising sea-surface temperatures over the next century alter benthic distributions and fish migration patterns. These concerns also extend to mariculture operations around oil production rigs or offshore wind farms, both of which would also add substrate for epibenthic microalgae. [Copyright &y& Elsevier]
AB - Copyright of Harmful Algae is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POISONOUS fishes -- Toxicology
KW - DINOFLAGELLATES
KW - TOXIC algae
KW - PETROLEUM
KW - MEXICO, Gulf of
KW - Artificial reefs
KW - Barracuda
KW - Ciguatera
KW - Gambierdiscus
KW - Global change
KW - Gulf of Mexico
N1 - Accession Number: 23808064; Villareal, T.A. 1; Email Address: tracy@utmsi.utexas.edu Hanson, S. 1 Qualia, Steve 2 Jester, E.L.E. 3 Granade, H.R. 3 Dickey, R.W. 3; Affiliation: 1: Marine Science Institute and Department of Marine Science, The University of Texas at Austin, 750 Channel View Dr., Port Aransas, TX 78373, United States 2: Fishtrackers Inc., P.O. Box 4746, Corpus Christi, TX 78469, United States 3: Food and Drug Administration, Gulf Coast Seafood Laboratory, Chemical Hazards Research Unit, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, United States; Source Info: Feb2007, Vol. 6 Issue 2, p253; Subject Term: POISONOUS fishes -- Toxicology; Subject Term: DINOFLAGELLATES; Subject Term: TOXIC algae; Subject Term: PETROLEUM; Subject Term: MEXICO, Gulf of; Author-Supplied Keyword: Artificial reefs; Author-Supplied Keyword: Barracuda; Author-Supplied Keyword: Ciguatera; Author-Supplied Keyword: Gambierdiscus; Author-Supplied Keyword: Global change; Author-Supplied Keyword: Gulf of Mexico; NAICS/Industry Codes: 424720 Petroleum and Petroleum Products Merchant Wholesalers (except Bulk Stations and Terminals); NAICS/Industry Codes: 424710 Petroleum Bulk Stations and Terminals; NAICS/Industry Codes: 412110 Petroleum and petroleum products merchant wholesalers; NAICS/Industry Codes: 486110 Pipeline Transportation of Crude Oil; NAICS/Industry Codes: 211111 Crude Petroleum and Natural Gas Extraction; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.hal.2006.08.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Derrick, Steven C.
AU - Evering, Teresa H.
AU - Sambandamurthy, Vasan K.
AU - Jalapathy, Kripa V.
AU - Tsungda Hsu
AU - Bing Chen
AU - Mei Chen
AU - Russell, Robert G.
AU - Junqueira-Kipnis, Ana Paula
AU - Orme, Ian M.
AU - Porcelli, Steven A.
AU - Jacobs Jr., William R.
AU - Morris, Sheldon L.
T1 - Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
JO - Immunology
JF - Immunology
Y1 - 2007/02//
VL - 120
IS - 2
M3 - Article
SP - 192
EP - 206
PB - Wiley-Blackwell
SN - 00192805
AB - The global epidemic of tuberculosis, fuelled by acquired immune-deficiency syndrome, necessitates the development of a safe and effective vaccine. We have constructed a ΔRD1ΔpanCD mutant of Mycobacterium tuberculosis (mc26030) that undergoes limited replication and is severely attenuated in immunocompromised mice, yet induces significant protection against tuberculosis in wild-type mice and even in mice that completely lack CD4+ T cells as a result of targeted disruption of their CD4 genes (CD4–/– mice). Ex vivo studies of T cells from mc26030-immunized mice showed that these immune cells responded to protein antigens of M. tuberculosis in a major histocompatibility complex (MHC) class II-restricted manner. Antibody depletion experiments showed that antituberculosis protective responses in the lung were not diminished by removal of CD8+, T-cell receptor γδ (TCR-γδ+) and NK1.1+ T cells from vaccinated CD4–/– mice before challenge, implying that the observed recall and immune effector functions resulting from vaccination of CD4–/– mice with mc26030 were attributable to a population of CD4– CD8– (double-negative) TCR-αβ+, TCR-γδ–, NK1.1– T cells. Transfer of highly enriched double-negative TCR-αβ+ T cells from mc26030-immunized CD4–/– mice into naive CD4–/– mice resulted in significant protection against an aerosol tuberculosis challenge. Enriched pulmonary double-negative T cells transcribed significantly more interferon-γ and interleukin-2 mRNA than double-negative T cells from naive mice after a tuberculous challenge. These results confirmed previous findings on the potential for a subset of MHC class II-restricted T cells to develop and function without expression of CD4 and suggest novel vaccination strategies to assist in the control of tuberculosis in human immunodeficiency virus-infected humans who have chronic depletion of their CD4+ T cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - CELLULAR immunity
KW - T cells
KW - MYCOBACTERIUM tuberculosis
KW - VACCINES
KW - BIOLOGICALS
KW - cytokines
KW - tuberculosis
KW - vaccine
N1 - Accession Number: 23573948; Derrick, Steven C. 1; Email Address: steven.derrick@fda.hhs.gov Evering, Teresa H. 2 Sambandamurthy, Vasan K. 2,3 Jalapathy, Kripa V. 2 Tsungda Hsu 2 Bing Chen 2,3 Mei Chen 2 Russell, Robert G. 4 Junqueira-Kipnis, Ana Paula 5 Orme, Ian M. 5 Porcelli, Steven A. 2 Jacobs Jr., William R. 2,3; Email Address: Jacobsw@hhmi.org Morris, Sheldon L. 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 2: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 3: Howard Hughes Medical Institute, Chevy Chase, MD 4: Department of Pathology, Lombardi Cancer Center, Georgetown University, Washington, DC 5: Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO, USA; Source Info: Feb2007, Vol. 120 Issue 2, p192; Subject Term: CYTOKINES; Subject Term: CELLULAR immunity; Subject Term: T cells; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: VACCINES; Subject Term: BIOLOGICALS; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: tuberculosis; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Illustrations: 2 Color Photographs, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2567.2006.02491.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23573948&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Mary Q.
AU - Yang, Jack Y.
AU - Ersoy, Okan K.
T1 - Classification of proteins multiple-labelled and single-labelled with protein functional classes.
JO - International Journal of General Systems
JF - International Journal of General Systems
Y1 - 2007/02//
VL - 36
IS - 1
M3 - Article
SP - 91
EP - 109
PB - Taylor & Francis Ltd
SN - 03081079
AB - Advances in high-throughput genome sequencing technology have led to an explosion in the amount of sequence data that are available. The determination of protein function using experimental techniques is time-consuming and expensive; the use of machine-learning techniques rapidly to assess protein function may be useful in streamlining this process. The problem of assigning functional classes to proteins is complicated by the fact that a single protein can participate in several different pathways and thus can have multiple functions. We have developed a tree-based classifier that is capable of handling multiple-labelled data and gaining an insight into the multi-functional nature of proteins. We call the resulting tree a recursive maximum contrast tree (RMCT) and the resulting classifier a multiple-labelled instance classifier (MLIC). We investigate the synergy of machine-learning-based ensemble methods and physiochemical-based feature augments. We test our algorithm on protein phylogenetic profiles generated from 60 completely sequenced genomes and we compare our results with those achieved by algorithms such as support vector machines and decision trees. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of General Systems is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTATIONAL intelligence
KW - PROTEINS
KW - MACHINE learning
KW - MACHINE theory
KW - BIOINFORMATICS
KW - RESEARCH
KW - Bioinformatics
KW - Classification
KW - Computational intelligence
KW - Machine learning
KW - Multifunctional proteins
N1 - Accession Number: 23369137; Yang, Mary Q. 1,2 Yang, Jack Y. 2,3; Email Address: jyang@hadron.mgh.harvard.edu Ersoy, Okan K. 2; Affiliation: 1: National Human Genome Research Institute-National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20852, USA 2: School of Electrical and Computer Engineering, Purdue University, W. Lafayette, IN, 47907, USA 3: Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Harvard University, Harvard Gardens Second Floor, Boston, MA 02114, USA; Source Info: Feb2007, Vol. 36 Issue 1, p91; Subject Term: COMPUTATIONAL intelligence; Subject Term: PROTEINS; Subject Term: MACHINE learning; Subject Term: MACHINE theory; Subject Term: BIOINFORMATICS; Subject Term: RESEARCH; Author-Supplied Keyword: Bioinformatics; Author-Supplied Keyword: Classification; Author-Supplied Keyword: Computational intelligence; Author-Supplied Keyword: Machine learning; Author-Supplied Keyword: Multifunctional proteins; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 19p; Illustrations: 3 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1080/03081070600950868
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23369137&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongtu Chen
AU - Cheal, Karen
AU - McDonel Herr, Elizabeth C.
AU - Zubritsky, Cynthia
AU - Levkoff, Sue E.
T1 - Religious participation as a predictor of mental health status and treatment outcomes in older persons.
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
Y1 - 2007/02//
VL - 22
IS - 2
M3 - Article
SP - 144
EP - 153
PB - John Wiley & Sons, Inc.
SN - 08856230
AB - Objectives This study focuses on examining the relations of religious participation and affiliation to mental health status among older primary care patients, and to the use and clinical outcomes of mental health services. Methods A sample of older adults participating in a clinical study (PRISM-E) to treat their depression with or without co-morbid anxiety (n = 1610) were queried about their religious affiliation and the frequency of their participation in religious activities. The diagnoses of depressive and anxiety disorders were made based on the MINI-International Neuropsychiatric Interview. Severity of depressive disorders was assessed by emotional distress using the CES-D. Results Those attending religious activities on a weekly, monthly, or occasional basis were significantly less likely to have suicidal ideation (p < 0.02) and emotional distress (p < 0.0001) than those who never participated or participated on a less frequent basis. Frequency of religious participation was not associated with mental health service utilization (p = 0.16), but it was predictive of a lower CES-D score at the end of the study intervention (p < 0.001). Conclusions Religious participation is positively associated with older adults' mental health status and treatment effects, but results regarding mental health service utilization were inconclusive. Copyright © 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - MENTAL health services
KW - PRIMARY care (Medicine)
KW - RELIGION
KW - ANXIETY
KW - alternative medicine
KW - elderly
KW - mental health
KW - primary care
KW - religious participation
N1 - Accession Number: 23849326; Hongtu Chen 1; Email Address: htchen@rics.bwh.harvard.edu Cheal, Karen 1 McDonel Herr, Elizabeth C. 2 Zubritsky, Cynthia 3 Levkoff, Sue E. 1; Affiliation: 1: Department of Psychiatry, Harvard Medical School, Boston, MA, USA 2: US Substance Abuse and Mental Health Services Administration, Center for Mental Health Services 3: University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USA; Source Info: Feb2007, Vol. 22 Issue 2, p144; Subject Term: MENTAL health; Subject Term: MENTAL health services; Subject Term: PRIMARY care (Medicine); Subject Term: RELIGION; Subject Term: ANXIETY; Author-Supplied Keyword: alternative medicine; Author-Supplied Keyword: elderly; Author-Supplied Keyword: mental health; Author-Supplied Keyword: primary care; Author-Supplied Keyword: religious participation; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1002/gps.1704
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Torma-Krajewski, Janet
AU - Steiner, Lisa
AU - Lewis, Pauline
AU - Gust, Paul
AU - Johnson, Kean
T1 - Implementation of an ergonomics process at a US surface coal mine
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2007/02//
VL - 37
IS - 2
M3 - Article
SP - 157
EP - 167
SN - 01698141
AB - Abstract: Since 1990 and the publication of the Ergonomics Program Management Guidelines for Meatpacking Plants by the US Occupational Safety and Health Administration, numerous reports of companies implementing ergonomics program have been published. However, despite these numerous reports, no examples of implementing an ergonomics program in the mining industry have been reported. In 2000, NIOSH initiated a long-term project to demonstrate the implementation of an ergonomics process designed to identify and reduce exposures to ergonomic risk factors found in mining. The mine selected for this project was the Jim Bridger Mine, a surface coal mine located 35 miles northeast of Rock Springs, Sweetwater County, WY. This paper discusses how a large, surface coal mine implemented an ergonomics program and the lessons learned while doing so. Relevance to industry: In 1998, the Mine Safety and Health Administration (MSHA) submitted a formal request to NIOSH to investigate musculoskeletal disorders (MSDs) in the mining industry. In response to MSHA''s request, NIOSH initiated a project at the Jim Bridger Mine that involved the implementation of an ergonomics process. This manuscript provides examples of successful interventions as well as recommendations and lessons learned from the implementation of an ergonomics process that will be beneficial to those initiating similar efforts. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Coal mines & mining
KW - Strip mining
KW - Ergonomics
KW - United States
KW - Ergonomics process
KW - Ergonomics program
KW - Mining
N1 - Accession Number: 23739466; Torma-Krajewski, Janet 1; Email Address: jht8@cdc.gov; Steiner, Lisa 1; Lewis, Pauline 1; Gust, Paul 2; Johnson, Kean 2; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; 2: Bridger Coal Company, Point of Rocks, WY 82942, USA; Issue Info: Feb2007, Vol. 37 Issue 2, p157; Thesaurus Term: Coal mines & mining; Thesaurus Term: Strip mining; Subject Term: Ergonomics; Subject: United States; Author-Supplied Keyword: Ergonomics process; Author-Supplied Keyword: Ergonomics program; Author-Supplied Keyword: Mining; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 333130 Mining and oil and gas field machinery manufacturing; NAICS/Industry Codes: 212111 Bituminous Coal and Lignite Surface Mining; NAICS/Industry Codes: 212113 Anthracite Mining; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ergon.2006.10.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moore, M. M.
AU - Feist, M. D.
T1 - Real-time PCR method for Salmonella spp. targeting the stn gene.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2007/02//
VL - 102
IS - 2
M3 - Article
SP - 516
EP - 530
PB - Wiley-Blackwell
SN - 13645072
AB - Aim: To develop a real-time PCR assay for Salmonella spp. targeting the stn gene. Methods and Results: The presence of stn in the Salmonella bongori genome was found by a BLAST with Salmonella enterica stn sequence. Manual alignment of stn sequences showed that Salm. bongori had 88% sequence identity with Salm. enterica. Two primers (stnL-433 and stnR-561) and a probe (stnP-452) were designed to target conserved regions in stn and meet the requirements of a 5′-nuclease assay. The primers and probe were evaluated against 353 isolates, including 255 Salm. enterica representing 158 serotypes, 14 Salm. bongori representing 12 serotypes and 84 non- Salmonella representing 56 species from 31 genera. All isolates were correctly identified, with the exception of three isolates of Citrobacter amalonaticus, which gave false positives. The limit of detection with cultured Salmonella was 3 CFU per reaction. Conclusions: The stn real-time PCR method had 100% inclusivity, 96·4% exclusivity and a level of detection of 3 CFU per reaction for cultured Salmonella spp. Significance and Impact of the Study: The study showed that stn is present in Salm. bongori and is a valid target for both species of Salmonella. The Salmonella s tn real-time PCR is a useful method for identifying Salmonella spp. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Foodborne diseases
KW - Polymerase chain reaction
KW - Bacterial genomes
KW - Enterotoxins
KW - enterotoxi
KW - enterotoxin
KW - real-time PCR
KW - Salmonella bongori
KW - stn
N1 - Accession Number: 23697532; Moore, M. M. 1; Email Address: michelle.moore@fda.hhs.gov; Feist, M. D. 1; Affiliations: 1: Seafood Products Research Center, Pacific Regional Laboratory Northwest, US Food and Drug Administration, Bothell, WA, USA; Issue Info: Feb2007, Vol. 102 Issue 2, p516; Thesaurus Term: Salmonella; Thesaurus Term: Foodborne diseases; Subject Term: Polymerase chain reaction; Subject Term: Bacterial genomes; Subject Term: Enterotoxins; Author-Supplied Keyword: enterotoxi; Author-Supplied Keyword: enterotoxin; Author-Supplied Keyword: real-time PCR; Author-Supplied Keyword: Salmonella bongori; Author-Supplied Keyword: stn; Number of Pages: 15p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1111/j.1365-2672.2006.03079.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yue, Lilly Q.
T1 - Statistical and Regulatory Issues with the Application of Propensity Score Analysis to Nonrandomized Medical Device Clinical Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/02//
VL - 17
IS - 1
M3 - Article
SP - 1
EP - 13
PB - Taylor & Francis Ltd
SN - 10543406
AB - Propensity score analysis is a versatile statistical method used mainly in observational studies for improving treatment comparison by adjusting for up to a relatively large number of potentially confounding covariates. Recently, there has been an increased interest in applying this method to nonrandomized medical device clinical studies. In the application of the methodology, some statistical and regulatory issues arise in both study design and analysis of study results, such as the need for pre-specifying clinically relevant covariates to be measured, appropriate patient populations, and the essential elements of statistical analysis, planning sample size in the context of propensity score methodology, handling missing covariates in generating propensity scores, and assessing the success of the propensity score method by evaluating treatment group overlap in terms of the distributions of propensity scores. In this paper, the advantages and limitations of this methodology will be revisited, and the above issues will be discussed and illustrated with examples from a regulatory perspective. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - MEDICAL statistics
KW - SAMPLING (Statistics)
KW - SAMPLE size (Statistics)
KW - METHODOLOGY
KW - PHILOSOPHICAL analysis
KW - Medical devices
KW - Nonrandomized studies
KW - Propensity score analysis
N1 - Accession Number: 23430083; Yue, Lilly Q. 1; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, MD, USA; Source Info: Feb2007, Vol. 17 Issue 1, p1; Subject Term: MEDICAL equipment; Subject Term: MEDICAL statistics; Subject Term: SAMPLING (Statistics); Subject Term: SAMPLE size (Statistics); Subject Term: METHODOLOGY; Subject Term: PHILOSOPHICAL analysis; Author-Supplied Keyword: Medical devices; Author-Supplied Keyword: Nonrandomized studies; Author-Supplied Keyword: Propensity score analysis; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 13p; Illustrations: 5 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10543400601044691
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yue, Lilly Q.
T1 - Rejoinder.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/02//
VL - 17
IS - 1
M3 - Article
SP - 43
EP - 43
PB - Taylor & Francis Ltd
SN - 10543406
AB - The author reflects on the positive comments from all discussants of his article about the application of propensity score analysis to non-randomized clinical studies. A smart selection strategy was proposed by discussants with the comparison to historical patients in data analysis. Other discussants also tackle sample size estimation issues from different views.
KW - SAMPLING (Statistics)
KW - PATIENTS
KW - SAMPLE size (Statistics)
KW - DATA analysis
KW - MEDICAL research
N1 - Accession Number: 23430085; Yue, Lilly Q. 1; Email Address: lilly.yue@fda.hhs.gov; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2007, Vol. 17 Issue 1, p43; Subject Term: SAMPLING (Statistics); Subject Term: PATIENTS; Subject Term: SAMPLE size (Statistics); Subject Term: DATA analysis; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 1p; Document Type: Article
L3 - 10.1080/10543400601051654
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23430085&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106124555
T1 - Applications of population pharmacokinetics in current drug labelling.
AU - Duan JZ
Y1 - 2007/02//
N1 - Accession Number: 106124555. Language: English. Entry Date: 20070727. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8704308.
KW - Drug Interactions
KW - Drug Labeling
KW - Pharmacokinetics
KW - Population
KW - Maryland
KW - United States Food and Drug Administration
KW - Human
SP - 57
EP - 79
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
JA - J CLIN PHARM THER
VL - 32
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background and Objective: The application of population pharmacokinetics (PopPK) appears increasingly in drug labelling. The current study was to examine the use of PopPK in dose recommendation in drug-product labels. Method: PopPK information was identified in the data sheets included in the physician desk reference (PDR). Electronic key word searches were conducted in the electronic library of PDR. The use of PopPK in the prescribing information, including the determination of dosing regimen, dosing in special populations and dose-adjustments was summarized and evaluated. The reliability and criteria for integrating the information derived from PopPK studies into the product labelling were discussed. Results and Discussion: Among more than 2500 items listed in the PDR, 88 listings were found to have PopPK information in the labelling. The information included general data (Gen) on pharmacokinetics (PK) and the effects of gender (sex), age, race, drug-drug interactions (DDI), smoking (Smk), alcohol consumption (Alc), disease state (Dis), renal impairment (Ren) and metabolic status (Met) on the PK parameters (Table). Whether there was an effect (+) or not (-) is also shown. Appendix 1 lists the products included in each category. GenSexAgeRaceDDISmkAlcDisRenMetTotal232734201991471+-8120940031 --1922201051440 Searches conducted at different times suggest an increase in both quantity and quality of PopPK data in drug development. PopPK is widely used in paediatric studies and the sample sizes in these studies are sometimes too small. The application of PopPK to protein drugs is increasing rapidly (Appendix 2). Several precautions should be exercised when PopPK is applied to protein drugs. When considering gender effects, different normalization methods for body weight have been used. The number of subjects included in the PopPK analysis should be given and the influence of the imbalance in any covariate should be investigated. PopPK-DDI results are particularly difficult to evaluate unless details about potentially influential factors such as dosing and sampling information for both drug and interacting drugs are given. Conclusions: The use of PopPK to aid optimal dosing is increasing. Several noticeable problems raised usually avoid the acceptability of PopPK studies. More investigations are needed to inform the development of consensuses on these issues. There is an accelerating shift from PopPK to PopPK/PD. The limitations of such modelling should be recognized.
SN - 0269-4727
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
U2 - PMID: 17286790.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hnizdo, Vladimir
AU - Darian, Eva
AU - Fedorowicz, Adam
AU - Demchuk, Eugene
AU - Shengqiao Li
AU - Singh, Harshinder
T1 - Nearest-neighbor nonparametric method for estimating the configurational entropy of complex molecules.
JO - Journal of Computational Chemistry
JF - Journal of Computational Chemistry
Y1 - 2007/02//
VL - 28
IS - 3
M3 - Article
SP - 655
EP - 668
SN - 01928651
AB - A method for estimating the configurational (i.e., non-kinetic) part of the entropy of internal motion in complex molecules is introduced that does not assume any particular parametric form for the underlying probability density function. It is based on the nearest-neighbor (NN) distances of the points of a sample of internal molecular coordinates obtained by a computer simulation of a given molecule. As the method does not make any assumptions about the underlying potential energy function, it accounts fully for any anharmonicity of internal molecular motion. It provides an asymptotically unbiased and consistent estimate of the configurational part of the entropy of the internal degrees of freedom of the molecule. The NN method is illustrated by estimating the configurational entropy of internal rotation of capsaicin and two stereoisomers of tartaric acid, and by providing a much closer upper bound on the configurational entropy of internal rotation of a pentapeptide molecule than that obtained by the standard quasi-harmonic method. As a measure of dependence between any two internal molecular coordinates, a general coefficient of association based on the information-theoretic quantity of mutual information is proposed. Using NN estimates of this measure, statistical clustering procedures can be employed to group the coordinates into clusters of manageable dimensions and characterized by minimal dependence between coordinates belonging to different clusters. © 2006 Wiley Periodicals, Inc. J Comput Chem 28: 655–668, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Computational Chemistry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTROPY
KW - MOLECULES
KW - SIMULATION methods & models
KW - PEPTIDES
KW - CAPSAICIN
KW - computer simulations
KW - configurational entropy
KW - internal rotation
KW - mutual information
KW - nearest neighbor
N1 - Accession Number: 23572546; Hnizdo, Vladimir 1; Email Address: vbh5@cdc.gov Darian, Eva 1 Fedorowicz, Adam 1 Demchuk, Eugene 1,2,3 Shengqiao Li 1,4 Singh, Harshinder 1,4; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333 3: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 4: Department of Statistics, West Virginia University, Morgantown, West Virginia 26506; Source Info: 2007, Vol. 28 Issue 3, p655; Subject Term: ENTROPY; Subject Term: MOLECULES; Subject Term: SIMULATION methods & models; Subject Term: PEPTIDES; Subject Term: CAPSAICIN; Author-Supplied Keyword: computer simulations; Author-Supplied Keyword: configurational entropy; Author-Supplied Keyword: internal rotation; Author-Supplied Keyword: mutual information; Author-Supplied Keyword: nearest neighbor; Number of Pages: 14p; Illustrations: 3 Diagrams, 2 Charts, 12 Graphs; Document Type: Article
L3 - 10.1002/jcc.20589
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Samuel Baron
AU - Jessica Hernandez
AU - Joseph Bekisz
AU - Joyce Poast
AU - Neil Goldman
AU - Kathleen Clouse
AU - Karen Fields
AU - Sylvia Bacot
AU - Jiun Wang
AU - Kathryn Zoon
T1 - Clinical Model Interferons Activate Human Monocytes to An Eradicative Tumor Cell Level In Vitro.
JO - Journal of Interferon & Cytokine Research
JF - Journal of Interferon & Cytokine Research
Y1 - 2007/02//
VL - 27
IS - 2
M3 - Article
SP - 157
EP - 164
SN - 10799907
AB - Eradicative levels of antitumor activity by cytokines and leukocytes have not yet been reached experimentally and are needed clinically. Only a limited number of human cancers respond to therapy with interferon (IFN), other cytokines, or mononuclear leukocytes despite significant antitumor activity in vitro. We studied the IFN and monocytic cell conditions that would lead to an eradicative effect using human cells in vitro. Targets of the IFN-activated monocytic cells were either four human tumor cell lines (human osteosarcoma [HOS], LOX melanoma, A549 lung tumor, and SNB-19 glioblastoma) or two diploid cell lines (WI38 and MRC5). An average of 30–90 colony-forming tumor target cells were cultured overnight in 96-well tissue culture plates prior to treatment with serially diluted IFN with or without activated elutriation-purified monocytes or lymphocytes. The target cell colonies were treated for 3 days. The colonies were then stained with crystal violet to determine the levels of antitumor activity. IFN-activated human monocytes reached an eradicative level (95–100) against three of four tumor cell lines. The eradicative level (1) was induced best in human monocytes activated by combined type I and II IFNs, (2) was effective against tumor cells that were growing for 24 h, (3) was specific for human tumors, as diploid human cells were not inhibited, and (4) required contact between the macrophage and the tumor cells. Also, for the first time, the minimal effective concentration (MEC) of IFNs to activate monocytes can approach those needed for antiviral activity. To our knowledge, this is the first report of near total eradication of many tumor cells, but not diploid cells, by IFN-activated monocytes. Because of its potency and specificity, the IFN-activated monocyte arm of the innate immune system may be a candidate for therapy of established tumors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Interferon & Cytokine Research is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEUCOCYTES
KW - CANCER cells
KW - CELL lines
KW - CELLULAR immunity
N1 - Accession Number: 24324932; Samuel Baron 1 Jessica Hernandez 2 Joseph Bekisz 2 Joyce Poast 1 Neil Goldman 2 Kathleen Clouse 3 Karen Fields 3 Sylvia Bacot 3 Jiun Wang 3 Kathryn Zoon 2; Affiliation: 1: University of Texas Medical Branch, Galveston, TX 77555. 2: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. 3: Food and Drug Administration, Bethesda, MD 20892.; Source Info: Feb2007, Vol. 27 Issue 2, p157; Subject Term: LEUCOCYTES; Subject Term: CANCER cells; Subject Term: CELL lines; Subject Term: CELLULAR immunity; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blackstone, George M.
AU - Nordstrom, Jessica L.
AU - Bowen, Michael D.
AU - Meyer, Richard F.
AU - Imbro, Paula
AU - DePaola, Angelo
T1 - Use of a real time PCR assay for detection of the ctxA gene of Vibrio cholerae in an environmental survey of Mobile Bay
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2007/02//
VL - 68
IS - 2
M3 - Article
SP - 254
EP - 259
SN - 01677012
AB - Abstract: Toxigenic Vibrio cholerae, the etiological agent of cholera, is a natural inhabitant of the marine environment and causes severe diarrheal disease affecting thousands of people each year in developing countries. It is the subject of extensive testing of shrimp produced and exported from these countries. We report the development of a real time PCR (qPCR) assay to detect the gene encoding cholera toxin, ctxA, found in toxigenic V. cholerae strains. This assay was tested against DNA isolated from soil samples collected from diverse locations in the US, a panel of eukaryotic DNA from various sources, and prokaryotic DNA from closely related and unrelated bacterial sources. Only Vibrio strains known to contain ctxA generated a fluorescent signal with the 5′ nuclease probe targeting the ctxA gene, thus confirming the specificity of the assay. In addition, the assay was quantitative in pure culture across a six-log dynamic range down to <10 CFU per reaction. To test the robustness of this assay, oysters, aquatic sediments, and seawaters from Mobile Bay, AL, were analyzed by qPCR and traditional culture methods. The assay was applied to overnight alkaline peptone water enrichments of these matrices after boiling the enrichments for 10 min. Toxigenic V. cholerae strains were not detected by either qPCR or conventional methods in the 16 environmental samples examined. A novel exogenous internal amplification control developed by us to prevent false negatives identified the samples that were inhibitory to the PCR. This assay, with the incorporated internal control, provides a highly specific, sensitive, and rapid detection method for the detection of toxigenic strains of V. cholerae. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO cholerae
KW - NUCLEIC acids
KW - VIBRIO infections
KW - PATHOLOGY
KW - Cholerae toxin
KW - Real time PCR
KW - Vibrio cholerae
N1 - Accession Number: 23806150; Blackstone, George M. 1; Email Address: George.Blackstone@fda.hhs.gov Nordstrom, Jessica L. 1 Bowen, Michael D. 2 Meyer, Richard F. 2 Imbro, Paula 3 DePaola, Angelo 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, AL 36528, USA 2: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA 3: Homeland Security Institute, Arlington, VA 22206, USA; Source Info: Feb2007, Vol. 68 Issue 2, p254; Subject Term: VIBRIO cholerae; Subject Term: NUCLEIC acids; Subject Term: VIBRIO infections; Subject Term: PATHOLOGY; Author-Supplied Keyword: Cholerae toxin; Author-Supplied Keyword: Real time PCR; Author-Supplied Keyword: Vibrio cholerae; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.mimet.2006.08.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vickery, Michael C.L.
AU - Nilsson, William B.
AU - Strom, Mark S.
AU - Nordstrom, Jessica L.
AU - DePaola, Angelo
T1 - A real-time PCR assay for the rapid determination of 16S rRNA genotype in Vibrio vulnificus
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2007/02//
VL - 68
IS - 2
M3 - Article
SP - 376
EP - 384
SN - 01677012
AB - Abstract: In a terminal restriction fragment polymorphism (T-RFLP) study, we recently reported a significant association between the type B 16S rRNA gene and clinical strains of Vibrio vulnificus associated with the consumption of raw oysters. In the present study we describe a real-time PCR assay for the rapid determination of the 16S rRNA type of V. vulnificus isolates. This assay was used to reexamine the 16S rRNA gene type in the strains studied previously by T-RFLP and additional isolates from selected sources. Analyses revealed that 15 of the strains (10 environmental and 5 clinical) previously found to be 16S rRNA type A actually appear to possess both the type A and B genes. The presence of both alleles was confirmed by cloning and sequencing both gene types from one strain. To our knowledge, this is the first report of 16S rRNA sequence heterogeneity within individual strains of V. vulnificus. The findings confirm the T-RFLP data that 16S rRNA type may be a useful marker for determining the clinical significance of V. vulnificus in disease in humans and cultured eels. The real-time PCR assay is much more rapid and less resource-intensive than T-RFLP, and should facilitate further study of the occurrence and distribution of the 16S rRNA genotypes of V. vulnificus. These studies should provide more definitive estimates of the risks associated with this organism and may lead to a better understanding of its virulence mechanism(s). [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - GENETIC research
KW - POLYMORPHISM (Zoology)
KW - GENETIC engineering
KW - 16S rRNA
KW - Real-time PCR
KW - Vibrio vulnificus
N1 - Accession Number: 23806168; Vickery, Michael C.L. 1; Email Address: michael.vickery@cepheid.com Nilsson, William B. 2 Strom, Mark S. 2 Nordstrom, Jessica L. 1; Email Address: jessica.nordstrom@fda.hhs.gov DePaola, Angelo 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U. S. Food and Drug Administration, Dauphin Island, Alabama 36528, United States 2: Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, United States Department of Commerce, Seattle, Washington 98112, United States; Source Info: Feb2007, Vol. 68 Issue 2, p376; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC research; Subject Term: POLYMORPHISM (Zoology); Subject Term: GENETIC engineering; Author-Supplied Keyword: 16S rRNA; Author-Supplied Keyword: Real-time PCR; Author-Supplied Keyword: Vibrio vulnificus; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mimet.2006.02.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23806168&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Damiani, Candice L.
AU - O'Callaghan, James P.
T1 - Recapitulation of cell signaling events associated with astrogliosis using the brain slice preparation.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2007/02//
VL - 100
IS - 3
M3 - Article
SP - 720
EP - 726
PB - Wiley-Blackwell
SN - 00223042
AB - Astroglial activation constitutes a dominant response to all types of injuries of the CNS. Despite the ubiquitous nature of this cellular reaction to neural injury, a little is known concerning the signaling mechanisms that initiate it. Recently, we demonstrated that astrocytic hypertrophy and enhanced expression of glial fibrillary acidic protein resulting from toxicant-induced neurodegeneration are linked to activation of the janus kinase (JAK)-signal transducer and activator of transcription-3 (STAT3) pathway. These observations implicate ligands at the gp130 receptor as potential upstream effectors of astrogliosis. Here we used the brain slice preparation to examine potential activators of the JAK-STAT3 pathway. Following incubation of freshly cut striatal slices in phosphate-free oxygenated buffer for up to 75 min, we found that slicing the striatum itself was a sufficient stimulus to initiate a rapid activation of the JAK-STAT3 pathway as assessed with immunoblots of pSTAT3(tyr705) using phospho-state specific antibodies. The mRNA for the gp130 cytokines, leukemia inhibitory factor, interleukin-6 and oncostatin M or the β-chemokine, monocyte chemoattractive protein (CCl2) also were up-regulated in the slice. Moreover, we could enhance the activation of STAT3(tyr705) by adding exogenous cytokines to the slice and we could inhibit phosphorylation of STAT3(tyr705) by addition of tyrosine kinase inhibitors (Lav A and AG490) or neutralizing antibodies directed against leukemia inhibitory factor or oncostatin M. These data suggest that STAT3 activation is an early event in slice-induced glial activation and establishes the brain slice preparation method as a reliable model to examine the signaling mechanisms that underlie glial activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROGLIA
KW - PROTEIN-tyrosine kinase
KW - IMMUNOGLOBULINS
KW - MESSENGER RNA
KW - CYTOKINES
KW - LEUKEMIA inhibitory factor
KW - INTERLEUKIN-6
KW - astrogliosis
KW - glial fibrillary acidic protein
KW - leukemia inhibitory factor
KW - oncostatin M
KW - protein phosphorylation
KW - signal transducer and activator of transcription-3
N1 - Accession Number: 23645550; Damiani, Candice L. 1 O'Callaghan, James P. 1; Email Address: jdo5@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (CDC-NIOSH), Morgantown, West Virginia, USA; Source Info: Feb2007, Vol. 100 Issue 3, p720; Subject Term: NEUROGLIA; Subject Term: PROTEIN-tyrosine kinase; Subject Term: IMMUNOGLOBULINS; Subject Term: MESSENGER RNA; Subject Term: CYTOKINES; Subject Term: LEUKEMIA inhibitory factor; Subject Term: INTERLEUKIN-6; Author-Supplied Keyword: astrogliosis; Author-Supplied Keyword: glial fibrillary acidic protein; Author-Supplied Keyword: leukemia inhibitory factor; Author-Supplied Keyword: oncostatin M; Author-Supplied Keyword: protein phosphorylation; Author-Supplied Keyword: signal transducer and activator of transcription-3; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1111/j.1471-4159.2006.04321.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23645550&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schneeman, Barbara
T1 - FDA's Review of Scientific Evidence for Health Claims1.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2007/02//
VL - 137
IS - 2
M3 - Article
SP - 493
EP - 494
SN - 00223166
AB - Under the Federal Food, Drug, and Cosmetic Act health claims on foods or dietary supplements must be authorized by the FDA. Health claims describe the relationship between a food, food component, or dietary supplement and reducing the risk of a disease or health-related condition. Under interim guidance and enforcement discretion, certain qualified health claims have been provided for on foods and dietary supplements; these claims contain language to qualify the quality and strength of scientific evidence to support the claim because they are not based on significant scientific agreement, which is the standard for health claims authorized by the Federal Food, Drug, and Cosmetic Act. In order to meet its statutory responsibility for evaluation of health claims, the agency has developed guidelines for review of scientific evidence in support of a health claim. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - FOOD
KW - DIETARY supplements
KW - HEALTH risk assessment
KW - PUBLIC health
KW - RISK assessment
KW - NUTRITION
KW - VITAMINS
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 23907685; Schneeman, Barbara 1; Email Address: barbara.schneeman@fda.hhs.gov.; Affiliation: 1: Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD; Source Info: Feb2007, Vol. 137 Issue 2, p493; Subject Term: HEALTH; Subject Term: FOOD; Subject Term: DIETARY supplements; Subject Term: HEALTH risk assessment; Subject Term: PUBLIC health; Subject Term: RISK assessment; Subject Term: NUTRITION; Subject Term: VITAMINS; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waters, Thomas R.
AU - Dick, Robert B.
AU - Davis-Barkley, Joi
AU - Krieg, Edward F.
T1 - A Cross-Sectional Study of Risk Factors for Musculoskeletal Symptoms in the Workplace Using Data From the General Social Survey (GSS).
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/02//
VL - 49
IS - 2
M3 - Article
SP - 172
EP - 184
SN - 10762752
AB - The article presents the findings of a study about risk factors for musculoskeletal symptoms in work environment. The study was conducted to assess the potential risk factors for musculoskeletal disorders that occur among the working population in the United States. The findings show a relationship between the musculoskeletal disorders and physical loads amongst the U.S. working population. The study shows that lower back pain and upper extremity disorders are two common work-related musculoskeletal disorders.
KW - MEDICAL research
KW - MUSCULOSKELETAL system -- Diseases
KW - WORK environment
KW - JOB satisfaction
KW - MUSCULOSKELETAL emergencies
KW - JOB stress
KW - BACK -- Diseases
KW - EMPLOYEE health promotion
KW - UNITED States
N1 - Accession Number: 24181045; Waters, Thomas R. 1; Email Address: twaters@cdc.gov Dick, Robert B. 1 Davis-Barkley, Joi 2 Krieg, Edward F. 1; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, Ohio. 2: Teachers College, Columbia University, New York.; Source Info: Feb2007, Vol. 49 Issue 2, p172; Subject Term: MEDICAL research; Subject Term: MUSCULOSKELETAL system -- Diseases; Subject Term: WORK environment; Subject Term: JOB satisfaction; Subject Term: MUSCULOSKELETAL emergencies; Subject Term: JOB stress; Subject Term: BACK -- Diseases; Subject Term: EMPLOYEE health promotion; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Document Type: Article
L3 - 10.1097/JOM.0b013e3180322559
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24181045&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desai, Meghna
AU - ter Kuile, Feiko O
AU - Nosten, François
AU - McGready, Rose
AU - Asamoa, Kwame
AU - Brabin, Bernard
AU - Newman, Robert D
T1 - Epidemiology and burden of malaria in pregnancy
JO - Lancet Infectious Diseases
JF - Lancet Infectious Diseases
Y1 - 2007/02//
VL - 7
IS - 2
M3 - Article
SP - 93
EP - 104
SN - 14733099
AB - Summary: We reviewed evidence of the clinical implications and burden of malaria in pregnancy. Most studies come from sub-Saharan Africa, where approximately 25 million pregnant women are at risk of Plasmodium falciparum infection every year, and one in four women have evidence of placental infection at the time of delivery. P falciparum infections during pregnancy in Africa rarely result in fever and therefore remain undetected and untreated. Meta-analyses of intervention trials suggest that successful prevention of these infections reduces the risk of severe maternal anaemia by 38%, low birthweight by 43%, and perinatal mortality by 27% among paucigravidae. Low birthweight associated with malaria in pregnancy is estimated to result in 100 000 infant deaths in Africa each year. Although paucigravidae are most affected by malaria, the consequences for infants born to multigravid women in Africa may be greater than previously appreciated. This is because HIV increases the risk of malaria and its adverse effects, particularly in multigravidae, and recent observational studies show that placental infection almost doubles the risk of malaria infection and morbidity in infants born to multigravidae. Outside Africa, malaria infection rates in pregnant women are much lower but are more likely to cause severe disease, preterm births, and fetal loss. Plasmodium vivax is common in Asia and the Americas and, unlike P falciparum, does not cytoadhere in the placenta, yet, is associated with maternal anaemia and low birthweight. The effect of infection in the first trimester, and the longer term effects of malaria beyond infancy, are largely unknown and may be substantial. Better estimates are also needed of the effects of malaria in pregnancy outside Africa, and on maternal morbidity and mortality in Africa. Global risk maps will allow better estimation of potential impact of successful control of malaria in pregnancy. [Copyright &y& Elsevier]
AB - Copyright of Lancet Infectious Diseases is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA
KW - PREGNANCY complications
KW - EPIDEMIOLOGY
KW - OBSTETRICS
KW - PREGNANT women -- Health
KW - PLASMODIUM falciparum
N1 - Accession Number: 23808016; Desai, Meghna 1; Email Address: mdesai@cdc.gov ter Kuile, Feiko O 1,2 Nosten, François 3,4 McGready, Rose 3,4 Asamoa, Kwame 1 Brabin, Bernard 2,5 Newman, Robert D 1,6; Affiliation: 1: Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA 2: Child and Reproductive Health, Liverpool School of Tropical Medicine, Liverpool, UK 3: Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand 4: Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK 5: Emmakinderziekenhuis, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands 6: United States Public Health Service, Rockville, MD, USA; Source Info: Feb2007, Vol. 7 Issue 2, p93; Subject Term: MALARIA; Subject Term: PREGNANCY complications; Subject Term: EPIDEMIOLOGY; Subject Term: OBSTETRICS; Subject Term: PREGNANT women -- Health; Subject Term: PLASMODIUM falciparum; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S1473-3099(07)70021-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23808016&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DeBell, Karen
AU - Graham, Laurie
AU - Reischl, Ilona
AU - Serrano, Carmen
AU - Bonvini, Ezio
AU - Rellahan, Barbara
T1 - Intramolecular Regulation of Phospholipase C-Γ1 by Its C-Terminal Src Homology 2 Domain.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2007/02//
VL - 27
IS - 3
M3 - Article
SP - 6
EP - 6
SN - 02707306
AB - Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is a key enzyme that governs cellular functions such as gene transcription, secretion, proliferation, motility, and development. Here, we show that PLC-γ1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain. Mutation of the SH2C domain tyrosine binding site led to constitutive PLC-γ1 activation. The amino-terminal split pleckstrin homology (sPHN) domain was found to regulate the accessibility of the SH2C domain. PLC-γ1 constructs with mutations in tyrosine 509 and phenylalanine 510 in the sPHN domain no longer required an intact amino-terminal Src homology (SH2N) domain or phosphorylation of tyrosine 775 or 783 for activation. These data are consistent with a model in which the SH2C domain is blocked by an intramolecular interaction(s) that is released upon cellular activation by occupancy of the SH2N domain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOINOSITIDES
KW - PHOSPHOLIPASE C
KW - ENZYMES
KW - TYROSINE
KW - PHENYLALANINE
N1 - Accession Number: 23966393; DeBell, Karen 1 Graham, Laurie 1 Reischl, Ilona 1 Serrano, Carmen 1 Bonvini, Ezio 2 Rellahan, Barbara 1; Email Address: barbara.rellahan@fda.hhs.gov; Affiliation: 1: Laboratory of Immunobiology, Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: MacroGenics, Inc., 1500 East Gude Drive, Rockville, Maryland; Source Info: Feb2007, Vol. 27 Issue 3, p6; Subject Term: PHOSPHOINOSITIDES; Subject Term: PHOSPHOLIPASE C; Subject Term: ENZYMES; Subject Term: TYROSINE; Subject Term: PHENYLALANINE; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/MCB.01400-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23966393&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trumbo, Paula R.
AU - Ellwood, Kathleen C.
T1 - Supplemental Calcium and Risk Reduction of Hypertension, Pregnancy-Induced Hypertension, and Preeclampsia: An Evidence-Based Review by the US Food and Drug Administration.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2007/02//
VL - 65
IS - 2
M3 - Article
SP - 78
EP - 87
SN - 00296643
AB - The labeling of health claims that meet the significant scientific agreement (SSA) standard (authorized health claims) and qualified health claims on conventional foods and dietary supplements requires premarket approval by the US Food and Drug Administration (FDA). FDA conducts an evidence-based review to determine whether there is sufficient evidence to support an authorized or qualified health claim. An evidence-based review was conducted on the human intervention and observational studies evaluating the role of supplemental calcium in reducing the risk of hypertension, pregnancy-induced hypertension, and preeclampsia. This review provides FDA's evaluation of the current scientific evidence on the role of supplemental calcium in reducing the risk of these three end points. Based on this evidence-based review, the agency concluded that the relationship between calcium and risk of hypertension is inconsistent and inconclusive, and the relationship between calcium and risk of pregnancy-induced hypertension and preeclampsia is highly unlikely. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Calcium
KW - RESEARCH
KW - Dietary supplements -- Evaluation
KW - Vitamins
KW - Hypertension -- Prevention
KW - Preeclampsia -- Prevention
KW - Pregnancy complications
KW - calcium
KW - hypertension
KW - pre-eclampsia
KW - pregnancy
KW - United States. Food & Drug Administration
N1 - Accession Number: 24522689; Trumbo, Paula R. 1; Email Address: Paula.Trumbo@FDA.HHS.gov; Ellwood, Kathleen C. 1; Affiliations: 1: Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, Maryland; Issue Info: Feb2007, Vol. 65 Issue 2, p78; Thesaurus Term: Calcium; Thesaurus Term: RESEARCH; Subject Term: Dietary supplements -- Evaluation; Subject Term: Vitamins; Subject Term: Hypertension -- Prevention; Subject Term: Preeclampsia -- Prevention; Subject Term: Pregnancy complications; Author-Supplied Keyword: calcium; Author-Supplied Keyword: hypertension; Author-Supplied Keyword: pre-eclampsia; Author-Supplied Keyword: pregnancy ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106254877
T1 - Supplemental calcium and risk reduction of hypertension, pregnancy-induced hypertension, and preeclampsia: an evidence-based review by the US Food and Drug Administration.
AU - Trumbo PR
AU - Ellwood KC
Y1 - 2007/02//
N1 - Accession Number: 106254877. Language: English. Entry Date: 20070323. Revision Date: 20150820. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. NLM UID: 0376405.
KW - Calcium Compounds -- Administration and Dosage
KW - Calcium, Dietary
KW - Dietary Supplementation
KW - Hypertension -- Prevention and Control
KW - Pre-Eclampsia -- Prevention and Control
KW - Pregnancy-Induced Hypertension -- Prevention and Control
KW - Consumer Health Information
KW - Descriptive Statistics
KW - Female
KW - Fetus
KW - Food Labeling
KW - Male
KW - Pregnancy
KW - Professional Practice, Evidence-Based
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 71
EP - 87
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 65
IS - 2
PB - Oxford University Press / USA
SN - 0029-6643
AD - Division of Nutrition Programs and Labeling, US Food and Drug Administration, HFSs-830, 5100 Paint Branch Parkway, College Park, MD 20740; Paula.Trumbo@FDA.HS.gov
U2 - PMID: 17345960.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106254877&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Alexander, Duane
AU - Van Dyck, Peter C.
T1 - In Reply—.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/02//
VL - 119
IS - 2
M3 - Letter
SP - 407
EP - 407
SN - 00314005
AB - A response by Duane Alexander and Peter C. van Dyck to a letter to the editor about their article "A Vision of the Future of Newborn Screening" in a 2006 issue of "Pediatrics" is presented.
KW - LETTERS to the editor
KW - NEWBORN infants -- Medical examinations
N1 - Accession Number: 23979749; Alexander, Duane 1 Van Dyck, Peter C. 2; Affiliation: 1: National Institutes of Health, Bethesda, MD 20892 2: Health Resources and Services Administration, Rockville, MD 20857; Source Info: Feb2007, Vol. 119 Issue 2, p407; Subject Term: LETTERS to the editor; Subject Term: NEWBORN infants -- Medical examinations; Number of Pages: 1p; Document Type: Letter
L3 - 10.1542/peds.2006-3178
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JAKAB, FERENC
AU - PÉTERFAI, JÁNOS
AU - VEREBÉLY, TIBOR
AU - MELEG, EDINA
AU - BÁNYAI, KRISZTIÁN
AU - MITCHELL, DOUGLAS K.
AU - SZÛCS, GYÖRGY
T1 - Human astrovirus infection associated with childhood intussusception.
JO - Pediatrics International
JF - Pediatrics International
Y1 - 2007/02//
VL - 49
IS - 1
M3 - Article
SP - 103
EP - 105
PB - Wiley-Blackwell
SN - 13288067
AB - The article discusses human astroviruses (HAstV) infection associated with intussusception in childhood and presents a case study of 28-month-old infant. Details related to the case study including patient history, diagnosis done and treatment suggested are discussed. The article suggest in favor of specific microbiological laboratory examinations for most cases of intussusception and oral rotavirus vaccine.
KW - VIRAL diseases in children
KW - INTUSSUSCEPTION in children
KW - ROTAVIRUS diseases -- Vaccination
KW - INTESTINES -- Infections
KW - PEDIATRIC diagnosis
KW - MICROBIOLOGICAL laboratories
KW - GASTROENTERITIS
KW - gastroenteritis
KW - human astrovirus
KW - intussusception
N1 - Accession Number: 23750093; JAKAB, FERENC 1,2; Email Address: jakabf@baranya.antsz.hu PÉTERFAI, JÁNOS 3 VEREBÉLY, TIBOR 4 MELEG, EDINA 1,2 BÁNYAI, KRISZTIÁN 1,2 MITCHELL, DOUGLAS K. 5 SZÛCS, GYÖRGY 1,2; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, University of Pécs, Pécs 2: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs 3: Department of Pediatrics, Municipal ‘szent László’ Hospital for Infectious Diseases 4: First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary 5: Center for Pediatric Research, Children’s Hospital of The King’s Daughters, Eastern Virginia Medical School, Norfolk, Virginia, USA; Source Info: Feb2007, Vol. 49 Issue 1, p103; Subject Term: VIRAL diseases in children; Subject Term: INTUSSUSCEPTION in children; Subject Term: ROTAVIRUS diseases -- Vaccination; Subject Term: INTESTINES -- Infections; Subject Term: PEDIATRIC diagnosis; Subject Term: MICROBIOLOGICAL laboratories; Subject Term: GASTROENTERITIS; Author-Supplied Keyword: gastroenteritis; Author-Supplied Keyword: human astrovirus; Author-Supplied Keyword: intussusception; NAICS/Industry Codes: 621511 Medical Laboratories; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1111/j.1442-200X.2007.02293.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tavris, Dale R.
AU - Gallauresi, Beverly Albrecht
AU - Dey, Syamal
AU - Brindis, Ralph
AU - Mitchel, Kristi
T1 - Risk of local adverse events by gender following cardiac catheterization.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/02//
VL - 16
IS - 2
M3 - Article
SP - 125
EP - 131
SN - 10538569
AB - Purpose To assess the reason for the relative high risk of local complications for women following cardiac catheterization by evaluating the associations between gender, sheath size, and local adverse outcomes following cardiac catheterization. Methods The data used in this study were obtained from a portion of the American College of Cardiology-National Cardiovascular Data Registry™ (ACC-NCDR™), which included 13 878 patients who underwent cardiac catheterization at one of 59 participating cardiac catheterization institutions throughout the United States during late 2003. Rates of serious local vascular adverse events were calculated by gender following cardiac catheterization, by type of vascular hemostasis used, stratified by arterial sheath size. Results Serious local vascular events were reported in 3.54% of patients, most commonly hematoma (2.00%). The relative risk for women of any vascular complication was 1.40 [95%CI = 1.17, 1.67, p = 0.0002]. A statistically significant relative risk for woman was evident when collagen plug devices or manual compression alone were used as the first method for hemostasis. The rate of vascular complications increased progressively with increasing sheath size, more so in women than in men. Conclusions High relative risk for women of local vascular complications following cardiac catheterization was demonstrated with use of manual compression, as well as with collagen plug devices to control femoral artery bleeding. Large sheath size is associated with both a relatively high absolute risk and a high relative risk for women. Knowledge of this information should be considered by interventional cardiologists in making decisions on how to achieve hemostasis following cardiac catheterization. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708337; Tavris, Dale R. 1; Gallauresi, Beverly Albrecht 1; Dey, Syamal 2; Brindis, Ralph 3; Mitchel, Kristi 2; Affiliations: 1: Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH) Epidemiology Branch Gallauresi Beverly, MA, USA; 2: American College of Cardiology (ACC), USA; 3: San Francisco Kaiser Hospital, on behalf of ACC-NCDR, San Francisco, CA, USA; Issue Info: Feb2007, Vol. 16 Issue 2, p125; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1307
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Miller, Sharon A.
AU - Coelho, Sergio C.
AU - Zmudzka, Barbara Z.
AU - Beer, Janusz Z.
T1 - Criticism of FDA pilot study unfounded (response to R. M. Sayre and J. C. Dowdy).
JO - Photodermatology, Photoimmunology & Photomedicine
JF - Photodermatology, Photoimmunology & Photomedicine
Y1 - 2007/02//
VL - 23
IS - 1
M3 - Letter
SP - 59
EP - 60
PB - Wiley-Blackwell
SN - 09054383
AB - A response by Sharon A. Miller, Sergio C. Coelho, Barbara Z. Zmudzka and Janusz Z. Beer to a letter to the editor about their article "Reduction of the UV burden to indoor tanners through new exposures schedules: a pilot study," in the October 18, 2006 issue is presented.
KW - LETTERS to the editor
KW - SUNTAN
N1 - Accession Number: 23784765; Miller, Sharon A. 1 Coelho, Sergio C. 2 Zmudzka, Barbara Z. 1 Beer, Janusz Z. 1; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD, USA 2: National Institutes of Health, National Cancer Institute, Bethesda, MD, USA; Source Info: Feb2007, Vol. 23 Issue 1, p59; Subject Term: LETTERS to the editor; Subject Term: SUNTAN; Number of Pages: 2p; Document Type: Letter
L3 - 10.1111/j.1600-0781.2007.00272.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miyamura, Yoshinori
AU - Coelho, Sergio G.
AU - Wolber, Rainer
AU - Miller, Sharon A.
AU - Wakamatsu, Kazumasa
AU - Zmudzka, Barbara Z.
AU - Ito, Shosuke
AU - Smuda, Christoph
AU - Passeron, Thierry
AU - Choi, Wonseon
AU - Batzer, Jan
AU - Yamaguchi, Yuji
AU - Beer, Janusz Z.
AU - Hearing, Vincent J.
T1 - Regulation of human skin pigmentation and responses to ultraviolet radiation.
JO - Pigment Cell Research
JF - Pigment Cell Research
Y1 - 2007/02//
VL - 20
IS - 1
M3 - Article
SP - 2
EP - 13
PB - Wiley-Blackwell
SN - 08935785
AB - Pigmentation of human skin is closely involved in protection against environmental stresses, in particular exposure to ultraviolet (UV) radiation. It is well known that darker skin is significantly more resistant to the damaging effects of UV, such as photocarcinogenesis and photoaging, than is lighter skin. Constitutive skin pigmentation depends on the amount of melanin and its distribution in that tissue. Melanin is significantly photoprotective and epidermal cells in darker skin incur less DNA damage than do those in lighter skin. This review summarizes current understanding of the regulation of constitutive human skin pigmentation and responses to UV radiation, with emphasis on physiological factors that influence those processes. Further research is needed to characterize the role of skin pigmentation to reduce photocarcinogenesis and to develop effective strategies to minimize such risks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pigment Cell Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN skin color
KW - ENVIRONMENTAL engineering
KW - ULTRAVIOLET radiation
KW - SKIN -- Wounds & injuries
KW - MELANINS
KW - DNA damage
KW - photoprotection
KW - pigmentation
KW - repeated irradiation
KW - skin
KW - ultraviolet
N1 - Accession Number: 23645483; Miyamura, Yoshinori 1 Coelho, Sergio G. 1 Wolber, Rainer 2 Miller, Sharon A. 3 Wakamatsu, Kazumasa 4 Zmudzka, Barbara Z. 3 Ito, Shosuke 4 Smuda, Christoph 2 Passeron, Thierry 1 Choi, Wonseon 1 Batzer, Jan 2 Yamaguchi, Yuji 1 Beer, Janusz Z. 3 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Department of Skin Research, Beiersdorf AG, Hamburg, Germany 3: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA 4: Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan; Source Info: Feb2007, Vol. 20 Issue 1, p2; Subject Term: HUMAN skin color; Subject Term: ENVIRONMENTAL engineering; Subject Term: ULTRAVIOLET radiation; Subject Term: SKIN -- Wounds & injuries; Subject Term: MELANINS; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: photoprotection; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: repeated irradiation; Author-Supplied Keyword: skin; Author-Supplied Keyword: ultraviolet; Number of Pages: 12p; Illustrations: 1 Color Photograph, 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1111/j.1600-0749.2006.00358.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Cutlip, Robert G.
AU - Andrew, Michael E.
AU - Dong, Ren G.
T1 - Simultaneous determination of the nonlinear-elastic properties of skin and subcutaneous tissue in unconfined compression tests.
JO - Skin Research & Technology
JF - Skin Research & Technology
Y1 - 2007/02//
VL - 13
IS - 1
M3 - Article
SP - 34
EP - 42
PB - Wiley-Blackwell
SN - 0909752X
AB - Background/aims: The compressive nonlinear-elastic properties of soft tissues are usually determined using unconfined compression tests. To determine the nonlinear-elastic behavior of skin and subcutaneous tissue using a conventional approach, the skin and subcutaneous tissue had to be separated before testing. Using such an approach, measurement errors may be increased as a consequence of the reduced specimen dimensions and cumulative experimental errors. In the present study, we propose a novel method to determine the nonlinear-elastic behaviors of the skin and the subcutaneous tissue simultaneously using specimens of skin/subcutaneous composites. Methods: The stress/strain curves of skin and subcutaneous tissues are derived from stress/strain curves of soft tissue specimens with different skin/subcutaneous height ratios. There is no need to separate the skin from the subcutaneous tissue in the tests, thereby improving the reliability and reducing measurement errors. In order to demonstrate the application of the proposed approach, unconfined compression tests with skin/subcutaneous tissues collected from the front paws of pigs were conducted. Results/Conclusion: Using the proposed approach, stress/strain relationships of the skin and the subcutaneous tissue were derived from data determined in eight unconfined compression tests. The obtained stress/strain curves were consistent with published experimental data. Compared with conventional methods, the proposed approach is not only more efficient but also more reliable. [ABSTRACT FROM AUTHOR]
AB - Copyright of Skin Research & Technology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUES
KW - SKIN
KW - DERMATOLOGY
KW - SEBACEOUS glands
KW - ORGANS (Anatomy)
KW - nonlinear-elasticity
KW - skin
KW - soft tissue
KW - subcutaneous
KW - unconfined compression
N1 - Accession Number: 23750108; Wu, John Z. 1; Email Address: jwu@cdc.gov Cutlip, Robert G. 1 Andrew, Michael E. 1 Dong, Ren G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, VA, USA; Source Info: Feb2007, Vol. 13 Issue 1, p34; Subject Term: TISSUES; Subject Term: SKIN; Subject Term: DERMATOLOGY; Subject Term: SEBACEOUS glands; Subject Term: ORGANS (Anatomy); Author-Supplied Keyword: nonlinear-elasticity; Author-Supplied Keyword: skin; Author-Supplied Keyword: soft tissue; Author-Supplied Keyword: subcutaneous; Author-Supplied Keyword: unconfined compression; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0846.2007.00182.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bak, Maarten
AU - van Os, Jim
AU - Delespaul, Philippe
AU - de Bie, Arthur
AU - á Campo, Joost
AU - Poddighe, Giovanni
AU - Drukker, Marian
T1 - An observational, “real life” trial of the introduction of assertive community treatment in a geographically defined area using clinical rather than service use outcome criteria.
JO - Social Psychiatry & Psychiatric Epidemiology
JF - Social Psychiatry & Psychiatric Epidemiology
Y1 - 2007/02//
VL - 42
IS - 2
M3 - Article
SP - 125
EP - 130
PB - Springer Science & Business Media B.V.
SN - 09337954
AB - Assertive outreach methods of service delivery hold promise, but have been evaluated mostly in the context of short-lived experiments of limited sustainability and a focus on service use outcomes. The aim of the current investigation was to conduct an observational, “real life”, pre-post comparison of the introduction of assertive outreach in a geographically defined area using clinical rather than service use outcome criteria. Assertive outreach was implemented in 2002 in a catchment area of 250,000, where cumulative routine outcome measurements had been in place since 1998. Clinical outcome, defined as making a transition to meeting the recently introduced remission criterion, was compared for two non-overlapping cohorts of patients treated in the period 1998–2001 and in the period 2002–2005. The proportion of patients that made the transition to remission increased from 19% in the period before the introduction of assertive outreach, to 31% in the period after (OR = 2.21, 95% CI 1.03–4.78). Assertive outreach in real life routine clinical practice brings about detectable changes in clinical outcome. ACT may bring improvement to the lives of patients living in countries characterised by fragmented and hospital-based mental health services. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Psychiatry & Psychiatric Epidemiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHIZOPHRENIA
KW - PSYCHOSES
KW - OUTCOME assessment (Medical care)
KW - MEDICAL care -- Evaluation
KW - CLINICAL medicine
KW - ACT
KW - outcome
KW - remission
KW - schizophrenia
KW - services
KW - SMI
N1 - Accession Number: 24798237; Bak, Maarten 1,2; Email Address: m.bak@sp.unimaas.nl van Os, Jim 1,3 Delespaul, Philippe 1,2 de Bie, Arthur 1,4 á Campo, Joost 5 Poddighe, Giovanni 6 Drukker, Marian 1,7; Affiliation: 1: Dept. of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616 (Vijverdal), 6200 MD Maastricht, The Netherlands 2: Psycope, Assertive Community Teams Maastricht, The Netherlands 3: Division of Psychological Medicine, Institute of Psychiatry, London, UK 4: Prins Claus Centrum (Mental health Centre), Sittard, The Netherlands 5: Mondriaan zorggroep, Heerlen, The Netherlands 6: Community Mental Health Centre, Maastricht, The Netherlands 7: Youth Health Care Division, Public Health Service South Limburg, Maastricht, The Netherlands; Source Info: Feb2007, Vol. 42 Issue 2, p125; Subject Term: SCHIZOPHRENIA; Subject Term: PSYCHOSES; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL care -- Evaluation; Subject Term: CLINICAL medicine; Author-Supplied Keyword: ACT; Author-Supplied Keyword: outcome; Author-Supplied Keyword: remission; Author-Supplied Keyword: schizophrenia; Author-Supplied Keyword: services; Author-Supplied Keyword: SMI; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1007/s00127-006-0147-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brook Martin
T1 - Reoperation Rates Following Lumbar Spine Surgery and the Influence of Spinal Fusion Procedures.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2007/02//
VL - 32
IS - 3
M3 - Article
SP - 382
EP - 387
SN - 03622436
AB - STUDY DESIGN.: Retrospective cohort study using a hospital discharge registry of all nonfederal acute care hospitals in Washington state. OBJECTIVES.: To determine the cumulative incidence of reoperation following lumbar surgery for degenerative disease and, for specific diagnoses, to compare the frequency of reoperation following fusion with that following decompression alone. SUMMARY OF BACKGROUND DATA.: Repeat lumbar spine operations are generally undesirable, implying persistent symptoms, progression of degenerative changes, or treatment complications. Compared to decompression alone, spine fusion is commonly viewed as a stabilizing treatment that may reduce the need for additional surgery. However, indications for fusion surgery in degenerative spine disorders remain controversial, and the effects of fusion on reoperation rates are unclear. METHODS.: Adults who underwent inpatient lumbar surgery for degenerative spine disorders in 1990–1993 (n = 24,882) were identified from International Classification of Diseases ninth Revision, Clinical Modification codes and then categorized as having either a lumbar decompression surgery or lumbar fusion surgery. We then compared the subsequent incidence of lumbar spine surgery between these groups. RESULTS.: Patients who had surgery in 1990–93 had a 19% cumulative incidence of reoperation during the subsequent 11 years. Patients with spondylolisthesis had a lower cumulative incidence of reoperation after fusion surgery than after decompression alone (17.1% vs. 28.0%, P = 0.002). For other diagnoses combined, the cumulative incidence of reoperation was higher following fusion than following decompression alone (21.5% vs. 18.8%, P = 0.008). After fusion surgery, 62.5% of reoperations were associated with a diagnosis suggesting device complication or pseudarthrosis. CONCLUSION.: Patients should be informed that the likelihood of reoperation following a lumbar spine operation is substantial. For spondylolisthesis, reoperation is less likely following fusion than following decompression alone. For other degenerative spine conditions, the cumulative incidence of reoperation is higher or unimproved after a fusion procedure compared to decompression alone. [ABSTRACT FROM AUTHOR]
AB - Copyright of Spine (03622436) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOTAL hip replacement -- Reoperation
KW - REOPERATION
KW - SPINAL cord
KW - OPERATIVE surgery
N1 - Accession Number: 23877310; Brook Martin 1; Affiliation: 1: From the Department of *Medicine, †Center for Cost and Outcomes Research, ‡Department of Orthopaedics and Sports Medicine, and §Department of Health Services, University of Washington; and the ∥Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Seattle, WA.; Source Info: Feb2007, Vol. 32 Issue 3, p382; Subject Term: TOTAL hip replacement -- Reoperation; Subject Term: REOPERATION; Subject Term: SPINAL cord; Subject Term: OPERATIVE surgery; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lachenbruch, Peter A.
AU - Miller, Frederick W.
AU - Rider, Lisa G.
T1 - Developing international consensus on measures of improvement for patients with myositis.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2007/02//
VL - 16
IS - 1
M3 - journal article
SP - 51
EP - 64
PB - Sage Publications, Ltd.
SN - 09622802
AB - We discuss methods of developing consensus in measuring improvement in myositis. We consider selecting candidate variables, reliability and validity, percentage improvement/worsening rules, rules based on CART and logistic regression. We discuss criteria for determining an acceptable rule that include both numerical measures and physician acceptance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSENSUS (Social sciences)
KW - MYOSITIS
KW - PATIENTS
KW - MUSCLES -- Diseases
KW - REGRESSION analysis
KW - MEDICAL care -- Evaluation
KW - CLINICAL trials
KW - INTERNATIONAL relations
KW - LOGISTIC regression analysis
KW - TREATMENT effectiveness
KW - TREATMENT
N1 - Accession Number: 25219060; Lachenbruch, Peter A. 1; Email Address: lachenbruchpa@aol.com Miller, Frederick W. 2 Rider, Lisa G. 2; Affiliation: 1: FDA Center for Biologics Evaluation and Research, USA 2: National Institute of Environmental Health Sciences, USA; Source Info: Feb2007, Vol. 16 Issue 1, p51; Subject Term: CONSENSUS (Social sciences); Subject Term: MYOSITIS; Subject Term: PATIENTS; Subject Term: MUSCLES -- Diseases; Subject Term: REGRESSION analysis; Subject Term: MEDICAL care -- Evaluation; Subject Term: CLINICAL trials; Subject Term: INTERNATIONAL relations; Subject Term: LOGISTIC regression analysis; Subject Term: TREATMENT effectiveness; Subject Term: TREATMENT; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 911410 Foreign affairs; Number of Pages: 14p; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, C.S.
AU - Ross, I.A.
AU - Sprando, R.L.
AU - Johnson, W.D.
AU - Sahu, S.C.
AU - Flynn, T.J.
AU - Wiesenfeld, P.L.
AU - Collins, T.F.X.
AU - O'Neill, R.K.
AU - Sapienza, P.
T1 - Distribution of and its effects on total free fatty acids in pregnant rats.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2007/02//
VL - 23
IS - 2
M3 - Article
SP - 65
EP - 74
PB - Sage Publications, Ltd.
SN - 07482337
AB - Androstenedione, an anabolic steroid used to enhance athletic performance, was administered in corn oil by gastric intubation once daily in the morning to nonpregnant female rats at a dose of 5 or 60 mg/kg/day, beginning two weeks before mating and continuing through gestation day (GD) 19. On GD 20, the distribution of androstenedione and other steroid metabolites was investigated in the maternal plasma and target organs, including brain and liver. The concentration of estradiol in plasma approached a statistically significant increase after treatment as compared with the controls, whereas the levels of androstenedione, testosterone and progesterone were not significantly different from the controls. In the liver, the concentrations of androstenedione and estradiol only were increased in a dose-related manner. None of these steroids was detectable in the brain. Androstenedione treatment also produced changes in the level of selected free fatty acids (FFAs) in the maternal blood, brain, liver and fetal brain. The concentrations of palmitic acid (16:0) and stearic acid (18:0) in the plasma were not significantly different between the controls and treated rats. However, oleic acid (18:1), linoleic acid (18:2) and docosahexaenoic acid (DHA, 22:6) were 17.94 ± 2.06 µg/ml, 24.23 ± 2.42 µg/ml and 4.08 ± 0.53 µg/ml, respectively, in the controls, and none of these fatty acids was detectable in the treated plasma. On the other hand, palmitic, stearic, oleic, linoleic and DHA were present in both control and treated livers. Among the FFAs in liver, linoleic and DHA were increased 87% and 169%, respectively, over controls. Palmitic, stearic and oleic acids were not significantly affected by the 60 mg/kg treatment. These were present in both control maternal and fetal brains, whereas linoleic acid was found only in fetal brain control. DHA was present only in the control maternal brain (0.02 ± 0.02 µg/mg protein) and fetal brain (0.24 ± 0.15 µg/mg protein). The results indicated that androstenedione exhibits significantly different effects on the FFA composition among target organs during pregnancy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Steroids
KW - Androgens
KW - Anabolic steroids
KW - Estrogen
KW - Omega-3 fatty acids
KW - Oleic acid
KW - androstenedione
KW - brain
KW - free fatty acids
KW - liver
KW - Oxidative stress
KW - pregnant rats
N1 - Accession Number: 32815197; Kim, C.S. 1,2; Email Address: chung.kim@fda.hhs.gov; Ross, I.A. 1,2; Sprando, R.L. 1,2; Johnson, W.D. 1,2; Sahu, S.C. 1,2; Flynn, T.J. 1,2; Wiesenfeld, P.L. 1,2; Collins, T.F.X. 1,2; O'Neill, R.K. 1,3; Sapienza, P. 2; Affiliations: 1: US FDA, Center for Food Safety and Applied Nutrition, MD 20708, USA; 2: Office of Applied Research and Safety Assessment, MD 20708, USA; 3: Office of the Scientific Analysis and Support, Laurel, MD 20708, USA; Issue Info: 2007, Vol. 23 Issue 2, p65; Thesaurus Term: Steroids; Subject Term: Androgens; Subject Term: Anabolic steroids; Subject Term: Estrogen; Subject Term: Omega-3 fatty acids; Subject Term: Oleic acid; Author-Supplied Keyword: androstenedione; Author-Supplied Keyword: brain; Author-Supplied Keyword: free fatty acids; Author-Supplied Keyword: liver; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: pregnant rats; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1177/0748233707076774
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stantchev, Tzanko S.
AU - Markovic, Ingrid
AU - Telford, William G.
AU - Clouse, Kathleen A.
AU - Broder, Christopher C.
T1 - The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages
JO - Virus Research
JF - Virus Research
Y1 - 2007/02//
VL - 123
IS - 2
M3 - Article
SP - 178
EP - 189
SN - 01681702
AB - Abstract: Binding of HIV-1 envelope glycoprotein (Env) to its cellular receptors elicits a variety of signaling events, including the activation of select tyrosine kinases. To evaluate the potential role of such signaling, we examined the effects of the tyrosine kinase inhibitor, genistein, on HIV-1 entry and infection of human macrophages using a variety of assays. Without altering cell viability, cell surface expression of CD4 and CCR5 or their abilities to interact with Env, genistein inhibited infection of macrophages by reporter gene-encoding, β-lactamase containing, or wild type virions, as well as Env-mediated cell-fusion. The observation that genistein blocked virus infection if applied before, during or immediately after the infection period, but not 24h later; coupled with a more pronounced inhibition of infection in the reporter gene assays as compared to both β-lactamase and p24 particle entry assays, imply that genistein exerts its inhibitory effects on both entry and early post-entry steps. These findings suggest that other exploitable targets, or steps, of the HIV-1 infection process may exist and could serve as additional opportunities for the development of new therapeutics. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - PROTEIN binding
KW - PROTEIN-tyrosine kinase
KW - CELL membranes
KW - MACROPHAGES
KW - CELL hybridization
KW - VIRUS diseases
KW - ASSAYING
KW - CCR5
KW - CD4
KW - CXCR4
KW - Entry
KW - Envelope glycoprotein
KW - Fusion
KW - Genistein
KW - gp120
KW - HIV
KW - Infection
KW - Macrophage
KW - Receptor
KW - Tyrosine kinase
N1 - Accession Number: 23670122; Stantchev, Tzanko S. 1 Markovic, Ingrid 2 Telford, William G. 3 Clouse, Kathleen A. 2 Broder, Christopher C. 1; Email Address: cbroder@usuhs.mil; Affiliation: 1: Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University Bethesda, 4301 Jones Bridge Road, MD 20814, USA 2: Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 3: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Feb2007, Vol. 123 Issue 2, p178; Subject Term: GLYCOPROTEINS; Subject Term: PROTEIN binding; Subject Term: PROTEIN-tyrosine kinase; Subject Term: CELL membranes; Subject Term: MACROPHAGES; Subject Term: CELL hybridization; Subject Term: VIRUS diseases; Subject Term: ASSAYING; Author-Supplied Keyword: CCR5; Author-Supplied Keyword: CD4; Author-Supplied Keyword: CXCR4; Author-Supplied Keyword: Entry; Author-Supplied Keyword: Envelope glycoprotein; Author-Supplied Keyword: Fusion; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: gp120; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Infection; Author-Supplied Keyword: Macrophage; Author-Supplied Keyword: Receptor; Author-Supplied Keyword: Tyrosine kinase; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.virusres.2006.09.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23670122&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-19129-002
AN - 2007-19129-002
AU - Duan, J. Z.
T1 - Applications of population pharmacokinetics in current drug labelling.
JF - Journal of Clinical Pharmacy and Therapeutics
JO - Journal of Clinical Pharmacy and Therapeutics
JA - J Clin Pharm Ther
Y1 - 2007/02//
VL - 32
IS - 1
SP - 57
EP - 79
CY - United Kingdom
PB - Blackwell Publishing
SN - 0269-4727
SN - 1365-2710
AD - Duan, J. Z., Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, US, 20993
N1 - Accession Number: 2007-19129-002. PMID: 17286790 Partial author list: First Author & Affiliation: Duan, J. Z.; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20080922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Dosages; Drug Interactions; Prescription Drugs; Treatment Guidelines; Pharmacokinetics. Minor Descriptor: Population. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Appended. References Available: Y. Page Count: 23. Issue Publication Date: Feb, 2007.
AB - Background and Objective: The application of population pharmacokinetics (PopPK) appears increasingly in drug labelling. The current study was to examine the use of PopPK in dose recommendation in drug-product labels. Method: PopPK information was identified in the data sheets included in the physician desk reference (PDR). Electronic key word searches were conducted in the electronic library of PDR. The use of PopPK in the prescribing information, including the determination of dosing regimen, dosing in special populations and dose-adjustments was summarized and evaluated. The reliability and criteria for integrating the information derived from PopPK studies into the product labelling were discussed. Results and Discussion: Among more than 2500 items listed in the PDR, 88 listings were found to have PopPK information in the labelling. The information included general data (Gen) on pharmacokinetics (PK) and the effects of gender (sex), age, race, drug-drug interactions (DDI), smoking (Smk), alcohol consumption (Alc), disease state (Dis), renal impairment (Ren) and metabolic status (Met) on the PK parameters (Table). Whether there was an effect (+) or not (-) is also shown. Appendix 1 lists the products included in each category. Searches conducted at different times suggest an increase in both quantity and quality of PopPK data in drug development. PopPK is widely used in paediatric studies and the sample sizes in these studies are sometimes too small. The application of PopPK to protein drugs is increasing rapidly (Appendix 2). Several precautions should be exercised when PopPK is applied to protein drugs. When considering gender effects, different normalization methods for body weight have been used. The number of subjects included in the PopPK analysis should be given and the influence of the imbalance in any covariate should be investigated. PopPK-DDI results are particularly difficult to evaluate unless details about potentially influential factors such as dosing and sampling information for both drug and interacting drugs are given. Conclusions: The use of PopPK to aid optimal dosing is increasing. Several noticeable problems raised usually avoid the acceptability of PopPK studies. More investigations are needed to inform the development of consensuses on these issues. There is an accelerating shift from PopPK to PopPK/PD. The limitations of such modelling should be recognized. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - population pharmacokinetics
KW - current drug labeling
KW - drug-product labels
KW - drug drug interaction
KW - dose recommendations
KW - 2007
KW - Drug Dosages
KW - Drug Interactions
KW - Prescription Drugs
KW - Treatment Guidelines
KW - Pharmacokinetics
KW - Population
KW - 2007
DO - 10.1111/j.1365-2710.2007.00799.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19129-002&site=ehost-live&scope=site
UR - john.duan@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-01685-004
AN - 2007-01685-004
AU - Snowden, Lonnie R.
AU - Masland, Mary
AU - Guerrero, Rachel
T1 - Federal civil rights policy and mental health treatment access for persons with limited english proficiency.
JF - American Psychologist
JO - American Psychologist
JA - Am Psychol
Y1 - 2007/02//Feb-Mar, 2007
VL - 62
IS - 2
SP - 109
EP - 117
CY - US
PB - American Psychological Association
SN - 0003-066X
SN - 1935-990X
AD - Snowden, Lonnie R., Center for Mental Health Services Research, University of California, 120 Haviland Hall, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2007-01685-004. PMID: 17324036 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, University of California, Berkeley, CA, US. Release Date: 20070226. Correction Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Snowden, Lonnie R. Major Descriptor: Civil Rights; Language Proficiency; Mental Health Services; Policy Making; Treatment Barriers. Minor Descriptor: Cross Cultural Treatment; Racial and Ethnic Differences; Communication Barriers. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: Feb-Mar, 2007. Copyright Statement: American Psychological Association. 2007.
AB - As noted in the supplement to the U.S. Surgeon General's report on mental health (U.S. Department of Health and Human Services, 2001), overcoming language access barriers associated with limited English proficiency (LEP) should help to eliminate racial and ethnic disparities in mental health care access and quality. Federal policy requires remedial action to overcome language barriers: Under Title VI of the Civil Rights Act of 1964, Medicaid and other federally funded programs must provide assistance to LEP persons. Some state-level public and mental health authorities have responded by instituting 'threshold language' policies. The history and terms of federal civil rights policy, and of threshold-language-policy-inspired initiatives, should be understood by everyone concerned with overcoming ethnic disparities in mental health services use. Concerned parties should promote implementation of required measures for language assistance and help to evaluate their implementation and effectiveness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - language access
KW - barriers to care
KW - limited English proficiency
KW - minority
KW - treatment disparities
KW - 2007
KW - Civil Rights
KW - Language Proficiency
KW - Mental Health Services
KW - Policy Making
KW - Treatment Barriers
KW - Cross Cultural Treatment
KW - Racial and Ethnic Differences
KW - Communication Barriers
KW - 2007
U1 - Sponsor: University of California, California Program on Access to Care, US. Recipients: Snowden, Lonnie R.; Masland, Mary; Guerrero, Rachel
U1 - Sponsor: California Department of Mental Health, US. Recipients: Snowden, Lonnie R.; Masland, Mary; Guerrero, Rachel
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01MH070942. Date: from Jul, 1997 to Jun, 2003. Recipients: Snowden, Lonnie R.; Masland, Mary; Guerrero, Rachel
DO - 10.1037/0003-066X.62.2.109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-01685-004&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02577-007
AN - 2007-02577-007
AU - Chen, Hongtu
AU - Cheal, Karen
AU - Herr, Elizabeth C. McDonel
AU - Zubritsky, Cynthia
AU - Levkoff, Sue E.
T1 - Religious participation as a predictor of mental health status and treatment outcomes in older persons.
T3 - Psychosocial interventions for mental illness in late-life
JF - International Journal of Geriatric Psychiatry
JO - International Journal of Geriatric Psychiatry
JA - Int J Geriatr Psychiatry
Y1 - 2007/02//
VL - 22
IS - 2
SP - 144
EP - 153
CY - US
PB - John Wiley & Sons
SN - 0885-6230
SN - 1099-1166
AD - Chen, Hongtu, Department of Psychiatry, Brigham and Women's Hospital, 1249 Boylston Street, 3rd Floor, Boston, MA, US, 02215
N1 - Accession Number: 2007-02577-007. PMID: 17245799 Partial author list: First Author & Affiliation: Chen, Hongtu; Department of Psychiatry, Harvard Medical School, Boston, MA, US. Release Date: 20070618. Correction Date: 20130715. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Mental Health; Mental Health Services; Primary Health Care; Religious Affiliation. Minor Descriptor: Health Care Utilization; Treatment Outcomes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Paykel Suicidal Questions; General Health Questionnaire; Beck Anxiety Inventory DOI: 10.1037/t02025-000; Center for Epidemiologic Studies Depression Scale; Mini International Neuropsychiatric Interview DOI: 10.1037/t18597-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Feb, 2007.
AB - Objectives: This study focuses on examining the relations of religious participation and affiliation to mental health status among older primary care patients, and to the use and clinical outcomes of mental health services. Methods: A sample of older adults participating in a clinical study (PRISM-E) to treat their depression with or without co-morbid anxiety (n = 1610) were queried about their religious affiliation and the frequency of their participation in religious activities. The diagnoses of depressive and anxiety disorders were made based on the MINI-International Neuropsychiatric Interview. Severity of depressive disorders was assessed by emotional distress using the CES-D. Results: Those attending religious activities on a weekly, monthly, or occasional basis were significantly less likely to have suicidal ideation (p < 0.02) and emotional distress (p < 0.0001) than those who never participated or participated on a less frequent basis. Frequency of religious participation was not associated with mental health service utilization (p = 0.16), but it was predictive of a lower CES-D score at the end of the study intervention (p < 0.001). Conclusions: Religious participation is positively associated with older adults' mental health status and treatment effects, but results regarding mental health service utilization were inconclusive. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - religious participation
KW - mental health status
KW - older primary care patients
KW - clinical outcomes
KW - mental health services
KW - 2007
KW - Aging
KW - Mental Health
KW - Mental Health Services
KW - Primary Health Care
KW - Religious Affiliation
KW - Health Care Utilization
KW - Treatment Outcomes
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Medicare and Medicaid Services (CMS). Recipients: No recipient indicated
DO - 10.1002/gps.1704
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02577-007&site=ehost-live&scope=site
UR - htchen@rics.bwh.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Beach, Dvora
AU - Gonen, Ronnie
AU - Bogin, Yaron
AU - Reischl, Ilona G.
AU - Yablonski, Deborah
T1 - Dual Role of SLP-76 in Mediating T Cell Receptor-induced Activation of Phospholipase C-β1.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2007/02/02/
VL - 282
IS - 5
M3 - Article
SP - 2937
EP - 2946
SN - 00219258
AB - Phospholipase C-γ1 (PLC-γ1) activation depends on a heterotrimeric complex of adaptor proteins composed of LAT, Gads, and SLP-76. Upon T cell receptor stimulation, a portion of PLC-γ1 is recruited to a detergent-resistant membrane fraction known as the glycosphmgolipid-enriched membrane microdomains (GEMs), or lipid rafts, to which LAT is constitutively localized. In addition to LAT, PLC-γ1 GEM recruitment depended on SLP-76, and, in particular, required the Gads-binding domain of SLP-76. The N-terminal tyrosine phosphorylation sites and P-I region of SLP-76 were not required for PLC-γ1 GEM recruitment, but were required for PLC-γ1 phosphorylation at Tyr783. Thus, GEM recruitment can be insufficient for full activation of PLC-γ1 in the absence of a second SLP-76-mediated event. Indeed, a GEM-targeted derivative of PLC-γ1 depended on SLP-76 for T cell receptor-induced phosphorylation at Tyr783 and subsequent NFAT activation. On a biochemical level, SLP-76 inducibly associated with both Vav and catalytically active ITK, which efficiently phosphorylated a PLC-γ1 fragment at Tyr783 in vitro. Both associations were disrupted upon mutation of the N-terminal tyrosine phosphorylation sites of SLP-76. The P-I region deletion disrupted Vav association and reduced SLP-76-associated kinase activity. A smaller deletion within the P-I region, which does not impair PLC-γ1 activation, did not impair the association with Vav, but reduced SLP-76-associated kinase activity. These results provide new insight into the multiple roles of SLP-76 and the functional importance of its interactions with other signaling proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOLIPASE C
KW - T cells
KW - CELL receptors
KW - PHOSPHORYLATION
KW - BIOCHEMISTRY
N1 - Accession Number: 24252544; Beach, Dvora 1 Gonen, Ronnie 1 Bogin, Yaron 1 Reischl, Ilona G. 2 Yablonski, Deborah 1; Email Address: debya@tx.technion.ac.il; Affiliation: 1: Rappaport Family Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel 2: Laboratory of Immunobiology, Division of MonoclonalAntibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, Maryland 20892; Source Info: 2/2/2007, Vol. 282 Issue 5, p2937; Subject Term: PHOSPHOLIPASE C; Subject Term: T cells; Subject Term: CELL receptors; Subject Term: PHOSPHORYLATION; Subject Term: BIOCHEMISTRY; Number of Pages: 10p; Illustrations: 6 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M606697200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grajkowski, Andrzej
AU - Ausín, Cristina
AU - Kauffman, Jon S.
AU - Snyder, John
AU - Hess, Sonja
AU - Lloyd, John R.
AU - Beaucage, Serge L.
T1 - Solid-Phase Synthesis of Thermolytic DNA Oligonucleotides Functionalized with a Single 4-Hydroxy-1-butyl or 4-Phosphato-/ Thiophosphato-1-butyl Thiophosphate Protecting Group.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2007/02/02/
VL - 72
IS - 3
M3 - Article
SP - 805
EP - 815
SN - 00223263
AB - Several thermolytic CpG-containing DNA oligonucleotides analogous to 1 have been synthesized to serve as potential immunotherapeutic oligonucleotide prodrug formulations for the treatment of infectious diseases in animal models. Specifically, the CpG motif (GACGTT) of each DNA oligonucleotide has been functionalized with either the thermolabile 4-hydroxy-1-butyl or the 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group. This functionalization was achieved through incorporation of activated deoxyribonucleoside phosphoramidite 8b into the oligonucleotide chain during solid-phase synthesis and, optionally, through subsequent phosphorylation effected by phosphoramidite 9. Complete conversion of CpG ODNs hbu1555, psb1555, and pob1555 to CpG ODN 1555 (homologous to 2) occurred under elevated temperature conditions, thereby validating the function of these diastereomeric oligonucleotides as prodrugs in vitro. Noteworthy is the significant increase in solubility of CpG ODN psb1555 and CpG pob1555 in water when compared to that of neutral CpG ODN final555 (homologous to 1). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - OLIGONUCLEOTIDES
KW - THIOPHOSPHATES
KW - IMMUNOTHERAPY
KW - COMMUNICABLE diseases
KW - PRODRUGS
N1 - Accession Number: 24078949; Grajkowski, Andrzej 1 Ausín, Cristina 1 Kauffman, Jon S. 2 Snyder, John 2 Hess, Sonja 3 Lloyd, John R. 3 Beaucage, Serge L. 1; Email Address: Serge.Beaucage@fda.hhs.gov; Affiliation: 1: Food and Drug Administration 2: Lancaster Laboratories 3: The National Institutes of Health; Source Info: 2/2/2007, Vol. 72 Issue 3, p805; Subject Term: DNA; Subject Term: OLIGONUCLEOTIDES; Subject Term: THIOPHOSPHATES; Subject Term: IMMUNOTHERAPY; Subject Term: COMMUNICABLE diseases; Subject Term: PRODRUGS; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kogan, Michael D.
AU - Newacheck, Paul W.
T1 - Introduction to the Volume on Articles From the National Survey of Children's Health.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/02/02/Feb2007 Supplement 1
VL - 119
M3 - Article
SP - S1
EP - S3
SN - 00314005
AB - The article discusses various issues published within the issue regarding the findings of the National Survey of Children's Health in the U.S.
KW - PREFACES & forewords
KW - CHILDREN -- Health
KW - access to health care
KW - ADHD
KW - adolescence
KW - breasfeeding
KW - family issues
N1 - Accession Number: 23954982; Kogan, Michael D. 1; Email Address: mkogan@hrsa.gov Newacheck, Paul W. 2,3; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: University of California Institute for Health Policy Studies 3: Department of Pediatrics, San Francisco, California; Source Info: Feb2007 Supplement 1, Vol. 119, pS1; Subject Term: PREFACES & forewords; Subject Term: CHILDREN -- Health; Author-Supplied Keyword: access to health care; Author-Supplied Keyword: ADHD; Author-Supplied Keyword: adolescence; Author-Supplied Keyword: breasfeeding; Author-Supplied Keyword: family issues; Number of Pages: 3p; Document Type: Article
L3 - 10.1542/peds.2006-20898
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - Dee, Deborah L.
T1 - Nativity/Immigrant Status, Race/Ethnicity, and Socioeconomic Determinants of Breastfeeding Initiation and Duration in the United States, 2003.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/02/02/Feb2007 Supplement 1
VL - 119
M3 - Article
SP - S38
EP - S46
SN - 00314005
AB - OBJECTIVES. Previous research has shown substantial racial/ethnic and socioeconomic disparities in US breastfeeding initiation and duration rates. However, the role of immigrant status in understanding such disparities has nut been well studied. In this study we examined the extent to which breastfeeding initiation and duration varied by immigrant status overall and in conjunction with race/ethnicity and socioeconomic status after controlling for other relevant social and behavioral covariates. METHODS. The cross-sectional data for 33 121 children aged 0 to 5 years from the 2003 National Survey of Children's Health were used to calculate ever-breast-feeding rates and duration rates at 3, 6, and 12 months by social factors. Multivariate logistic regression was used to estimate relative odds of never breastfeeding and not breastfeeding at 6 and 12 months. RESULTS. More than 72% of mothers reported ever breastfeeding their infants, with the duration rate declining to 52%, 38%, and 16% at 3, 6, and 12 months, respectively. Ever-breastfeeding rates varied greatly among the 12 ethnic-immigrant groups included in this analysis, from a low of 48% for native black children with native parents to a high of 88% among immigrant black and white children. Compared with immigrant Hispanic children with foreign-born parents (the least acculturated group), the odds of never breastfeeding were respectively 2.4, 2.9, 6.5, and 2.4 times higher for native children with native parents (the most acculturated group) of Hispanic, white, black, and other ethnicities. Socioeconomic patterns also varied by immigrant status, and differentials were greater in breastfeeding at 6 months. CONCLUSIONS. Immigrant women in each racial/ethnic group had higher breastfeeding initiation and longer duration rates than native women. Acculturation was associated with lower breastfeeding rates among both Hispanic and non-Hispanic women. Ethnic-immigrant and social groups with lower breastfeeding rates identified herein could be targeted for breastfeeding promotion programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREASTFEEDING (Humans)
KW - SOCIOECONOMICS
KW - REGRESSION analysis
KW - IMMIGRANTS
KW - UNITED States
KW - acculturation
KW - Asians
KW - breastfeeding initiation and duration
KW - disparities
KW - Hispanics
KW - immigrant status
KW - race/ethnicity
KW - social support
KW - socioeconomic status
KW - United States
N1 - Accession Number: 23954987; Singh, Gopal K. 1; Email Address: gsingh@hrsa.gov Kogan, Michael D. 1 Dee, Deborah L. 2; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland 2: Department of Maternal and Child Health, School of Public Health, University of North Carolina, Chapel Hill, North Carolina; Source Info: Feb2007 Supplement 1, Vol. 119, pS38; Subject Term: BREASTFEEDING (Humans); Subject Term: SOCIOECONOMICS; Subject Term: REGRESSION analysis; Subject Term: IMMIGRANTS; Subject Term: UNITED States; Author-Supplied Keyword: acculturation; Author-Supplied Keyword: Asians; Author-Supplied Keyword: breastfeeding initiation and duration; Author-Supplied Keyword: disparities; Author-Supplied Keyword: Hispanics; Author-Supplied Keyword: immigrant status; Author-Supplied Keyword: race/ethnicity; Author-Supplied Keyword: social support; Author-Supplied Keyword: socioeconomic status; Author-Supplied Keyword: United States; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1542/peds.2006-2089G
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23954987&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bramlett, Matthew D.
AU - Radel, Laura F.
AU - Blumberg, Stephen J.
T1 - The Health and Well-being of Adopted Children.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/02/02/Feb2007 Supplement 1
VL - 119
M3 - Article
SP - S54
EP - S60
SN - 00314005
AB - OBJECTIVE. We compared the health and well-being of adopted and biological children and examined whether observed differences may be a result of differences between these 2 groups in demographic characteristics and special health care needs. METHODS. The 2003 National Survey of Children's Health was funded by the Maternal and Child Health Bureau, Health Resources and Services Administration, and was conducted as a module of the State and Local Area Integrated Telephone Survey by the National Center for Health Statistics, Centers for Disease Control and Prevention. The nationally representative sample consisted of 102 353 children, including 2903 adopted children. We compared estimates for 31 indicators of health and well-being for adopted and biological children and present adjusted estimates that control for differences in demographic characteristics and special health care needs prevalence. RESULTS. Adopted children are more likely than biological children to have special health care needs, current moderate or severe health problems, learning disability, developmental delay or physical impairment, and other mental health difficulties. However, adopted children are more likely than biological children to have had a preventive medical visit or a combination of preventive medical and dental visits during the previous year, to receive needed mental health care, and to receive care in a medical home; they are more likely to have consistent health insurance coverage, to be read to daily, or to live in neighborhoods that are supportive, and they are less likely to live in households in which someone smokes. These differences between adopted and biological children remain statistically significant even after adjustments for differences in demographic characteristics and the prevalence of special health care needs. CONCLUSION. The results suggest that, although adopted children may have poorer health than biological children, their parents may be doing more to ensure that they have needed health care and supportive environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADOPTED children
KW - MEDICAL care
KW - TELEPHONE surveys
KW - LEARNING disabilities
KW - PREVENTIVE medicine
KW - adopted children
KW - children's health
KW - special health care needs
N1 - Accession Number: 23954989; Bramlett, Matthew D. 1; Email Address: mbramlett@cdc.gov Radel, Laura F. 2 Blumberg, Stephen J. 1; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 2: Office of Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC; Source Info: Feb2007 Supplement 1, Vol. 119, pS54; Subject Term: ADOPTED children; Subject Term: MEDICAL care; Subject Term: TELEPHONE surveys; Subject Term: LEARNING disabilities; Subject Term: PREVENTIVE medicine; Author-Supplied Keyword: adopted children; Author-Supplied Keyword: children's health; Author-Supplied Keyword: special health care needs; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1542/peds.2006-2089I
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van Dyck, Peter C.
T1 - Final Commentary on the Special Volume of Articles From the National Survey of Children's Health.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/02/02/Feb2007 Supplement 1
VL - 119
M3 - Article
SP - S122
EP - S123
SN - 00314005
AB - The article presents comments on epidemiologic and public health issues as highlighted by the findings of the Nation Survey of Children's Health in the U.S. Most children enjoy good health and well-being, live in families that function well and reside in safe and supportive neighborhoods. Family functioning plays an important role as a cause and consequence of children's health problems. Neighborhood cohesion and trust is important as a predictor of children's level of physical activity and being overweight.
KW - CHILDREN -- Health
KW - EPIDEMIOLOGY
KW - PUBLIC health
KW - FAMILIES
KW - NEIGHBORHOODS
KW - OVERWEIGHT children
N1 - Accession Number: 23954998; Van Dyck, Peter C. 1; Email Address: pvandyck@hrsa.gov; Affiliation: 1: Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857; Source Info: Feb2007 Supplement 1, Vol. 119, pS122; Subject Term: CHILDREN -- Health; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; Subject Term: FAMILIES; Subject Term: NEIGHBORHOODS; Subject Term: OVERWEIGHT children; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
L3 - 10.1542/peds.2006-2089R
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23954998&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106295959
T1 - Introduction to the volume on articles from the National Survey of Children's Health.
AU - Kogan MD
AU - Newacheck PW
Y1 - 2007/02/02/Feb2007 Supplement 1
N1 - Accession Number: 106295959. Language: English. Entry Date: 20070601. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Feb2007 Supplement 1. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child Health
KW - Maternal-Child Health
KW - Adolescence
KW - Adolescent Development
KW - Child
KW - Child Health Services
KW - Child Welfare
KW - Child, Adopted
KW - Child, Preschool
KW - Clinical Indicators
KW - Health Services Research
KW - Infant
KW - Mental Health
KW - Serial Publications
SP - S1
EP - 3
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 119
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857; mkogan@hrsa.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106295963
T1 - Nativity/immigrant status, race/ethnicity, and socioeconomic determinants of breastfeeding initiation and duration in the United States, 2003.
AU - Singh GK
AU - Kogan MD
AU - Dee DL
Y1 - 2007/02/02/Feb2007 Supplement 1
N1 - Accession Number: 106295963. Language: English. Entry Date: 20070601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Feb2007 Supplement 1. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Breast Feeding
KW - Emigration and Immigration
KW - Ethnic Groups
KW - Mothers
KW - Adult
KW - Chi Square Test
KW - Child, Preschool
KW - Cross Sectional Studies
KW - Female
KW - Health Status
KW - Infant
KW - Infant, Newborn
KW - Logistic Regression
KW - Odds Ratio
KW - Prevalence
KW - Socioeconomic Factors
KW - Support, Psychosocial
KW - Time Factors
KW - United States
KW - Human
SP - S38
EP - 46
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 119
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: Previous research has shown substantial racial/ethnic and socioeconomic disparities in US breastfeeding initiation and duration rates. However, the role of immigrant status in understanding such disparities has not been well studied. In this study we examined the extent to which breastfeeding initiation and duration varied by immigrant status overall and in conjunction with race/ethnicity and socioeconomic status after controlling for other relevant social and behavioral covariates. METHODS: The cross-sectional data for 33121 children aged 0 to 5 years from the 2003 National Survey of Children's Health were used to calculate ever-breastfeeding rates and duration rates at 3, 6, and 12 months by social factors. Multivariate logistic regression was used to estimate relative odds of never breastfeeding and not breastfeeding at 6 and 12 months. RESULTS: More than 72% of mothers reported ever breastfeeding their infants, with the duration rate declining to 52%, 38%, and 16% at 3, 6, and 12 months, respectively. Ever-breastfeeding rates varied greatly among the 12 ethnic-immigrant groups included in this analysis, from a low of 48% for native black children with native parents to a high of 88% among immigrant black and white children. Compared with immigrant Hispanic children with foreign-born parents (the least acculturated group), the odds of never breastfeeding were respectively 2.4, 2.9, 6.5, and 2.4 times higher for native children with native parents (the most acculturated group) of Hispanic, white, black, and other ethnicities. Socioeconomic patterns also varied by immigrant status, and differentials were greater in breastfeeding at 6 months. CONCLUSIONS: Immigrant women in each racial/ethnic group had higher breastfeeding initiation and longer duration rates than native women. Acculturation was associated with lower breastfeeding rates among both Hispanic and non-Hispanic women. Ethnic-immigrant and social groups with lower breastfeeding rates identified herein could be targeted for breastfeeding promotion programs.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA. gsingh@hrsa.gov
U2 - PMID: 17272583.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106295975
T1 - Final commentary on the special volume of articles from the National Survey of Children's Health.
AU - van Dyck PC
Y1 - 2007/02/02/Feb2007 Supplement 1
N1 - Accession Number: 106295975. Language: English. Entry Date: 20070601. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Feb2007 Supplement 1. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0376422.
KW - Child Welfare
KW - Child
KW - Government
KW - Health and Welfare Planning
KW - Health Services Research
KW - United States
SP - S122
EP - 3
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 119
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA. pvandyck@hrsa.gov
U2 - PMID: 17272580.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moore, Martha M.
AU - Honma, Masamitsu
AU - Clements, Julie
AU - Bolcsfoldi, George
AU - Burlinson, Brian
AU - Cifone, Maria
AU - Clarke, Jane
AU - Clay, Philip
AU - Doppalapudi, Rupa
AU - Fellows, Michael
AU - Gollapudi, Bhaskar
AU - Hou, Saimei
AU - Jenkinson, Peter
AU - Muster, Wolfgang
AU - Pant, Kamala
AU - Kidd, Darren A.
AU - Lorge, Elisabeth
AU - Lloyd, Melvyn
AU - Myhr, Brian
AU - O’Donovan, Michael
T1 - Mouse lymphoma thymidine kinase gene mutation assay: Meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 36
EP - 40
SN - 13835718
AB - Abstract: The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity Testing (IWGT), comprised of experts from Japan, Europe and the United States, met on September 9, 2005, in San Francisco, CA, USA. This meeting of the MLA Workgroup was devoted to reaching a consensus on issues involved with 24-h treatment. Recommendations were made concerning the acceptable values for the negative/solvent control (mutant frequency, cloning efficiency and suspension growth) and the criteria to define an acceptable positive control response. Consensus was also reached concerning the use of the global evaluation factor (GEF) and appropriate statistical trend analysis to define positive and negative responses for the 24-h treatment. The Workgroup agreed to continue their support of the International Committee on Harmonization (ICH) recommendation that the MLA assay should include a 24-h treatment (without S-9) in those situations where the short treatment (3–4h) gives negative results. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Genetic toxicology
KW - Lymphomas
KW - Lymphoproliferative disorders
KW - Thymidine
KW - Genes
KW - In vitro mutation
KW - Mouse lymphoma assay
KW - Thymidine kinase
N1 - Accession Number: 23673483; Moore, Martha M. 1; Email Address: Martha.Moore@fda.hhs.gov; Honma, Masamitsu 2; Clements, Julie 3; Bolcsfoldi, George 4; Burlinson, Brian 5; Cifone, Maria 6; Clarke, Jane 7; Clay, Philip 8; Doppalapudi, Rupa 9; Fellows, Michael 10; Gollapudi, Bhaskar 11; Hou, Saimei 4; Jenkinson, Peter 12; Muster, Wolfgang 13; Pant, Kamala 7; Kidd, Darren A. 3; Lorge, Elisabeth 14; Lloyd, Melvyn 3; Myhr, Brian 15; O’Donovan, Michael 10; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, USA; 2: National Institute of Health Sciences, Division of Genetics & Mutagenesis, Tokyo, Japan; 3: Covance Laboratories, Ltd., Harrogate, North Yorkshire, United Kingdom; 4: Safety Assessment, AstraZeneca R&D, Sodertalje, Sweden; 5: Huntingdon Life Sciences, Huntingdon, United Kingdom; 6: Covance Laboratories Inc., Vienna, VA, USA; 7: BioReliance Invitrogen Bioservices, Rockville, MD, USA; 8: Servier Group, Drug Safety Assessment, F-45403 Orleans-Gidy, France; 9: SRI International, Menlo Park, CA, USA; 10: Safety Assessment, AstraZeneca R&D, Alderley Park, Macclesfield, United Kingdom; 11: The Dow Chemical Company, TERC, Midland, MI, USA; 12: Safepharm Laboratories Ltd., Shardlow, Derbyshire, United Kingdom; 13: F. Hoffmann-La Roche Ltd., Basel, Switzerland; 14: Syngenta CTL, Alderley Park, Macclesfield SK10 4TJ, United Kingdom; 15: Genotox Consulting, Bethesda, MD, USA; Issue Info: Feb2007, Vol. 627 Issue 1, p36; Thesaurus Term: Mutation (Biology); Thesaurus Term: Genetic toxicology; Subject Term: Lymphomas; Subject Term: Lymphoproliferative disorders; Subject Term: Thymidine; Subject Term: Genes; Author-Supplied Keyword: In vitro mutation; Author-Supplied Keyword: Mouse lymphoma assay; Author-Supplied Keyword: Thymidine kinase; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.08.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thybaud, V.
AU - Aardema, M.
AU - Clements, J.
AU - Dearfield, K.
AU - Galloway, S.
AU - Hayashi, M.
AU - Jacobson-Kram, D.
AU - Kirkland, D.
AU - MacGregor, J.T.
AU - Marzin, D.
AU - Ohyama, W.
AU - Schuler, M.
AU - Suzuki, H.
AU - Zeiger, E.
T1 - Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 41
EP - 58
SN - 13835718
AB - Abstract: This report summarizes the proceedings of the September 9–10, 2005 meeting of the Expert Working Group on Hazard Identification and Risk Assessment in Relation to In Vitro Testing, part of an initiative on genetic toxicology. The objective of the Working Group was to develop recommendations for interpretation of results from tests commonly included in regulatory genetic toxicology test batteries, and to propose an appropriate strategy for follow-up testing when positive in vitro results were obtained in these assays. The Group noted the high frequency of positive in vitro findings in the genotoxicity test batteries with agents found not to be carcinogenic and thought not to pose a carcinogenic health hazard to humans. The Group agreed that a set of consensus principles for appropriate interpretation and follow-up testing when initial in vitro tests are positive was needed. Current differences in emphasis and policy among different regulatory agencies were recognized as a basis of this need. Using a consensus process among a balanced group of recognized international authorities from industry, government, and academia, it was agreed that a strategy based on these principles should include guidance on: (1) interpretation of initial results in the “core” test battery; (2) criteria for determining when follow-up testing is needed; (3) criteria for selecting appropriate follow-up tests; (4) definition of when the evidence is sufficient to define the mode of action and the relevance to human exposure; and (5) definition of approaches to evaluate the degree of health risk under conditions of exposure of the species of concern (generally the human). A framework for addressing these issues was discussed, and a general “decision tree” was developed that included criteria for assessing the need for further testing, selecting appropriate follow-up tests, and determining a sufficient weight of evidence to attribute a level of risk and stop testing. The discussion included case studies based on actual test results that illustrated common situations encountered, and consensus opinions were developed based on group analysis of these cases. The Working Group defined circumstances in which the pattern and magnitude of positive results was such that there was very low or no concern (e.g., non-reproducible or marginal responses), and no further testing would be needed. This included a discussion of the importance of the use of historical control data. The criteria for determining when follow-up testing is needed included factors, such as evidence of reproducibility, level of cytotoxicity at which an increased DNA damage or mutation frequency is observed, relationship of results to the historical control range of values, and total weight of evidence across assays. When the initial battery is negative, further testing might be required based on information from the published literature, structure activity considerations, or the potential for significant human metabolites not generated in the test systems. Additional testing might also be needed retrospectively when increase in tumors or evidence of pre-neoplastic change is seen. When follow-up testing is needed, it should be based on knowledge about the mode of action, based on reports in the literature or learned from the nature of the responses observed in the initial tests. The initial findings, and available information about the biochemical and pharmacological nature of the agent, are generally sufficient to conclude that the responses observed are consistent with certain molecular mechanisms and inconsistent with others. Follow-up tests should be sensitive to the types of genetic damage known to be capable of inducing the response observed initially. It was recognized that genotoxic events might arise from processes other than direct reactivity with DNA, that these mechanisms may have a non-linear, or threshold, dose-response relationship, and that in such cases it may be possible to determine an exposure level below which there is negligible concern about an effect due to human exposures. When a test result is clearly positive, consideration of relevance to human health includes whether other assays for the same endpoint support the results observed, whether the mode or mechanism of action is relevant to the human, and – most importantly – whether the effect observed is likely to occur in vivo at concentrations expected as a result of human exposure. Although general principles were agreed upon, time did not permit the development of recommendations for the selection of specific tests beyond those commonly employed in initial test batteries. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Toxicology
KW - Carcinogenesis
KW - Risk assessment
KW - Toxicity testing -- In vitro
KW - Genotoxicity
KW - Hazard identification
KW - Testing strategy
N1 - Accession Number: 23673484; Thybaud, V. 1; Email Address: Veronique.Thybaud@sanofi-aventis.com; Aardema, M. 2; Clements, J. 3; Dearfield, K. 4; Galloway, S. 5; Hayashi, M. 6; Jacobson-Kram, D. 7; Kirkland, D. 3; MacGregor, J.T. 8; Marzin, D. 9; Ohyama, W. 10; Schuler, M. 11; Suzuki, H. 12; Zeiger, E. 13; Affiliations: 1: Drug Safety Evaluation, Sanofi-aventis, 94400 Vitry sur Seine, France; 2: The Procter & Gamble Co., P.O. Box 538707, Cincinnati Ohio 45253, USA; 3: Covance Laboratories Ltd., Otley Road, Harrogate HG3 1PY, UK; 4: Food Safety and Inspection Service, Office of Public Health Science, U.S. Department of Agriculture, Washington, DC 20250, USA; 5: Merck Research Laboratories, West Point, PA 19486, USA; 6: Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan; 7: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA; 8: Toxicology Consulting Services, Arnold, MD 21012, USA; 9: Institut Pasteur de Lille, BP 245, 59019 Lille Cedex, France; 10: Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitach-shi, Tokyo 186-8650, Japan; 11: Pfizer Global Research & Development, Groton, CT 06340, USA; 12: Ina Research Inc., 2148-188 Nishiminowa, Ina-shi, Nagano 399-4501, Japan; 13: Errol Zeiger Consulting, Chapel Hill, NC 27514, USA; Issue Info: Feb2007, Vol. 627 Issue 1, p41; Thesaurus Term: Genetic toxicology; Thesaurus Term: Toxicology; Thesaurus Term: Carcinogenesis; Thesaurus Term: Risk assessment; Subject Term: Toxicity testing -- In vitro; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Hazard identification; Author-Supplied Keyword: Testing strategy; NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.10.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23673484&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ku, Warren W.
AU - Bigger, Anita
AU - Brambilla, Giovanni
AU - Glatt, Hansruedi
AU - Gocke, Elmar
AU - Guzzie, Peggy J.
AU - Hakura, Atsushi
AU - Honma, Masamitsu
AU - Martus, Hans-Joerg
AU - Obach, R. Scott
AU - Roberts, Stanley
T1 - Strategy for genotoxicity testing—Metabolic considerations
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 59
EP - 77
SN - 13835718
AB - Abstract: The report from the 2002 International Workshop on Genotoxicity Tests (IWGT) Strategy Expert Group emphasized metabolic considerations as an important area to address in developing a common strategy for genotoxicity testing. A working group convened at the 2005 4th IWGT to discuss this area further and propose practical strategy recommendations. To propose a strategy, the working group reviewed: (1) the current status and deficiencies, including examples of carcinogens “missed” in genotoxicity testing, established shortcomings of the standard in vitro induced S9 activation system and drug metabolite case examples; (2) the current status of possible remedies, including alternative S9 sources, other external metabolism systems or genetically engineered test systems; (3) any existing positions or guidance. The working group established consensus principles to guide strategy development. Thus, a human metabolite of interest should be represented in genotoxicity and carcinogenicity testing, including evaluation of alternative genotoxicity in vitro metabolic activation or test systems, and the selection of a carcinogenicity test species showing appropriate biotransformation. Appropriate action triggers need to be defined based on the extent of human exposure, considering any structural knowledge of the metabolite, and when genotoxicity is observed upon in vitro testing in the presence of metabolic activation. These triggers also need to be considered in defining the timing of human pharmaceutical ADME assessments. The working group proposed two strategies to consider; a more proactive approach, which emphasizes early metabolism predictions to drive appropriate hazard assessment; and a retroactive approach to manage safety risks of a unique or “major” metabolite once identified and quantitated from human clinical ADME studies. In both strategies, the assessment of the genotoxic potential of a metabolite could include the use of an alternative or optimized in vitro metabolic activation system, or direct testing of an isolated or synthesized metabolite. The working group also identified specific areas where more data or experiences need to be gained to reach consensus. These included defining a discrete exposure action trigger for safety assessment and when direct testing of a metabolite of interest is warranted versus the use of an alternative in vitro activation system, a universal recommendation for the timing of human ADME studies for drug candidates and the positioning of metabolite structural knowledge (through in silico systems, literature, expert analysis) in supporting metabolite safety qualification. Lastly, the working group outlined future considerations for refining the initially proposed strategies. These included the need for further evaluation of the current in vitro genotoxicity testing protocols that can potentially perturb or reduce the level of metabolic activity (potential alterations in metabolism associated with both the use of some solvents to solubilize test chemicals and testing to the guidance limit dose), and proposing broader evaluations of alternative metabolic activation sources or engineered test systems to further challenge the suitability of (or replace) the current induced liver S9 activation source. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Carcinogenesis
KW - Carcinogenicity
KW - Carcinogens
KW - Chemical mutagenesis
KW - Genotoxicity
KW - Metabolism
KW - Strategy
KW - Testing
N1 - Accession Number: 23673485; Ku, Warren W. 1; Email Address: warren.w.ku@pfizer.com; Bigger, Anita 2; Brambilla, Giovanni 3; Glatt, Hansruedi 4; Gocke, Elmar 5; Guzzie, Peggy J. 1; Hakura, Atsushi 6; Honma, Masamitsu 7; Martus, Hans-Joerg 8; Obach, R. Scott 9; Roberts, Stanley 10; Affiliations: 1: Pfizer Global Research and Development, Drug Safety Research and Development, Groton, CT 06340, USA; 2: U.S. Food and Drug Administration, CDER, Division of Antiviral Products, Silver Spring, MD 20993, United States; 3: Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, I-16132 Genoa, Italy; 4: German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany; 5: F. Hoffmann-La Roche Ltd., Preclinical Safety, CH-4070 Basel, Switzerland; 6: Eisai Co., Ltd., Drug Safety Research Laboratories, Kakamigahara, GIFU 501-6195, Japan; 7: National Institute of Health Sciences, Division of Genetics & Mutagenesis, Tokyo, Setagaya-Ku 158-8501, Japan; 8: Novartis Pharma AG, Exploratory Development, Genetic Toxicology and Safety Pharmacology, 4002 Basel, Switzerland; 9: Pfizer Global Research and Development, Pharmacokinetics, Dynamics and Metabolism, Groton, CT 06340, USA; 10: Abbott Laboratories, Drug Metabolism and Pharmacokinetics, Abbott Park, IL 60064, USA; Issue Info: Feb2007, Vol. 627 Issue 1, p59; Thesaurus Term: Genetic toxicology; Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogenicity; Thesaurus Term: Carcinogens; Subject Term: Chemical mutagenesis; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Strategy; Author-Supplied Keyword: Testing; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.10.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23673485&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tweats, D.J.
AU - Blakey, D.
AU - Heflich, R.H.
AU - Jacobs, A.
AU - Jacobsen, S.D.
AU - Morita, T.
AU - Nohmi, T.
AU - O’Donovan, M.R.
AU - Sasaki, Y.F.
AU - Sofuni, T.
AU - Tice, R.
T1 - Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests: I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 78
EP - 91
SN - 13835718
AB - Abstract: In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro is realised in vivo and to detect any genotoxic carcinogens that are poorly detected in vitro. It is recognised that individual in vivo genotoxicity tests have limited sensitivity but good specificity. Thus, a positive result from the established in vivo assays is taken as strong evidence for genotoxic carcinogenicity of the compound tested. However, there is a growing body of evidence that compound-related disturbances in the physiology of the rodents used in these assays can result in increases in micronucleated cells in the bone marrow that are not related to the intrinsic genotoxicity of the compound under test. For rodent bone marrow or peripheral blood micronucleus tests, these disturbances include changes in core body temperature (hypothermia and hyperthermia) and increases in erythropoiesis following prior toxicity to erythroblasts or by direct stimulation of cell division in these cells. This paper reviews relevant data from the literature and also previously unpublished data obtained from a questionnaire devised by the IWGT working group. Regulatory implications of these findings are discussed and flow diagrams have been provided to aid in interpretation and decision-making when such changes in physiology are suspected. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Rodents
KW - Genetic toxicology
KW - Toxicology
KW - Carcinogenesis
KW - Toxicity testing -- In vivo
KW - Bone marrow -- Blood-vessels
KW - Bone marrow cell toxicity
KW - Changes in physiology
KW - Erythropoiesis
KW - False positive
KW - Genotoxicity tests
KW - Hyperthermia
KW - Hypothermia
KW - In vivo
KW - IWGT
KW - Micronucleus
KW - Pharmacologically related changes
KW - Regulatory implications
KW - Rodent bone marrow
KW - Specificity
KW - Spindle disruption
N1 - Accession Number: 23673486; Tweats, D.J. 1; Email Address: djtweats@fish.co.uk; Blakey, D. 2; Heflich, R.H. 3; Jacobs, A. 4; Jacobsen, S.D. 5; Morita, T. 6; Nohmi, T. 7; O’Donovan, M.R. 8; Sasaki, Y.F. 9; Sofuni, T. 7; Tice, R. 10; Affiliations: 1: Centre for Molecular Genetics and Toxicology, University of Wales, Swansea, UK; 2: Safe Environments Programme, Health Canada, Ottawa, Canada; 3: National Center for Toxicological Research, US FDA, HFT-120, Jefferson, AR 72079, USA; 4: Office of New Drugs, Center for Drug Evaluation and Research, U.S. FDA, HFD024, Rockville, MD 20852, USA; 5: Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark; 6: Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences, Tokyo, Japan; 7: Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan; 8: Safety Assessment UK, AstraZeneca R&D Alderley Park, Mereside, Macclesfield, Cheshire, UK; 9: Hachinohe National College of Technology, Hachinohe, Aomori, Japan; 10: National Institute of Environmental Health Sciences, EC-17, Research Triangle Park, NC 27709, USA; Issue Info: Feb2007, Vol. 627 Issue 1, p78; Thesaurus Term: Rodents; Thesaurus Term: Genetic toxicology; Thesaurus Term: Toxicology; Thesaurus Term: Carcinogenesis; Subject Term: Toxicity testing -- In vivo; Subject Term: Bone marrow -- Blood-vessels; Author-Supplied Keyword: Bone marrow cell toxicity; Author-Supplied Keyword: Changes in physiology; Author-Supplied Keyword: Erythropoiesis; Author-Supplied Keyword: False positive; Author-Supplied Keyword: Genotoxicity tests; Author-Supplied Keyword: Hyperthermia; Author-Supplied Keyword: Hypothermia; Author-Supplied Keyword: In vivo; Author-Supplied Keyword: IWGT; Author-Supplied Keyword: Micronucleus; Author-Supplied Keyword: Pharmacologically related changes; Author-Supplied Keyword: Regulatory implications; Author-Supplied Keyword: Rodent bone marrow; Author-Supplied Keyword: Specificity; Author-Supplied Keyword: Spindle disruption; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.10.005
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DB - eih
ER -
TY - JOUR
AU - Tweats, D.J.
AU - Blakey, D.
AU - Heflich, R.H.
AU - Jacobs, A.
AU - Jacobsen, S.D.
AU - Morita, T.
AU - Nohmi, T.
AU - O’Donovan, M.R.
AU - Sasaki, Y.F.
AU - Sofuni, T.
AU - Tice, R.
T1 - Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests: II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 92
EP - 105
SN - 13835718
AB - Abstract: A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily detected in vivo than in vitro. The reasons for this property varies from compound to compound and includes metabolic differences; the influence of gut flora; higher exposures in vivo compared to in vitro; effects on pharmacology, in particular folate depletion or receptor kinase inhibition. It is possible that at least some of these compounds are detectable in vitro if a specific in vitro test is chosen as part of the test battery, but the ‘correct’ choice of test may not always be obvious when testing a compound of unknown genotoxicity. It is noted that many of the compounds identified in this study interfere with cell cycle kinetics and this can result in either aneugenicity or chromosome breakage. A decision tree is outlined as a guide for the evaluation of compounds that appear to be genotoxic agents in vivo but not in vitro. The regulatory implications of these findings are discussed. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Carcinogenesis
KW - Toxicity testing -- In vivo
KW - Bone marrow
KW - Nucleolus
KW - ADME
KW - Cosmetics
KW - Food additives
KW - Genotoxicity tests
KW - In vitro versus in vivo metabolism
KW - In vitro-only genotoxicity test batteries
KW - In vivo
KW - In vivo-only positive compounds
KW - Influence of gut flora
KW - IWGT
KW - Kinase inhibitors
KW - Micronucleus test
KW - Pharmaceuticals
KW - Pharmacological mechanisms
KW - Regulatory implication
KW - Rodent bone marrow
KW - Sex-specific metabolism
N1 - Accession Number: 23673487; Tweats, D.J. 1; Email Address: djtweats@fish.co.uk; Blakey, D. 2; Heflich, R.H. 3; Jacobs, A. 4; Jacobsen, S.D. 5; Morita, T. 6; Nohmi, T. 7; O’Donovan, M.R. 8; Sasaki, Y.F. 9; Sofuni, T. 7; Tice, R. 10; Affiliations: 1: Centre for Molecular Genetics and Toxicology, University of Wales Swansea, UK; 2: Safe Environments Programme, Health Canada, Ottawa, Canada; 3: National Center for Toxicological Research, US FDA, HFT-120, Jefferson, AR 72079, USA; 4: Office of New Drugs, Center for Drug Evaluation and Research, US FDA, HFD024, Rockville, MD 20852, USA; 5: Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark; 6: Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan; 7: Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan; 8: Safety Assessment UK, AstraZeneca R&D Alderley Park, Mereside, Macclesfield, Cheshire, UK; 9: Hachinohe National College of Technology, Hachinohe, Aomori, Japan; 10: National Institute of Environmental Health Sciences, EC-17, Research Triangle Park, NC 27709, USA; Issue Info: Feb2007, Vol. 627 Issue 1, p92; Thesaurus Term: Genetic toxicology; Thesaurus Term: Carcinogenesis; Subject Term: Toxicity testing -- In vivo; Subject Term: Bone marrow; Subject Term: Nucleolus; Author-Supplied Keyword: ADME; Author-Supplied Keyword: Cosmetics; Author-Supplied Keyword: Food additives; Author-Supplied Keyword: Genotoxicity tests; Author-Supplied Keyword: In vitro versus in vivo metabolism; Author-Supplied Keyword: In vitro-only genotoxicity test batteries; Author-Supplied Keyword: In vivo; Author-Supplied Keyword: In vivo-only positive compounds; Author-Supplied Keyword: Influence of gut flora; Author-Supplied Keyword: IWGT; Author-Supplied Keyword: Kinase inhibitors; Author-Supplied Keyword: Micronucleus test; Author-Supplied Keyword: Pharmaceuticals; Author-Supplied Keyword: Pharmacological mechanisms; Author-Supplied Keyword: Regulatory implication; Author-Supplied Keyword: Rodent bone marrow; Author-Supplied Keyword: Sex-specific metabolism; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.10.006
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DB - eih
ER -
TY - JOUR
AU - Kasper, Peter
AU - Uno, Yoshifumi
AU - Mauthe, Robert
AU - Asano, Norihide
AU - Douglas, George
AU - Matthews, Edwin
AU - Moore, Martha
AU - Mueller, Lutz
AU - Nakajima, Madoka
AU - Singer, Tim
AU - Speit, Guenter
T1 - Follow-up testing of rodent carcinogens not positive in the standard genotoxicity testing battery: IWGT workgroup report
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/02/03/
VL - 627
IS - 1
M3 - Article
SP - 106
EP - 116
SN - 13835718
AB - Abstract: At the Plymouth Third International Workshop on Genotoxicity Testing in June 2002, a new expert group started a working process to provide guidance on a common strategy for genotoxicity testing beyond the current standard battery. The group identified amongst others “Follow-up testing of tumorigenic agents not positive in the standard genotoxicity test battery” as one subject for further consideration [L. Müller, D. Blakey, K.L. Dearfield, S. Galloway, P. Guzzie, M. Hayashi, P. Kasper, D. Kirkland, J.T. MacGregor, J.M. Parry, L. Schechtman, A. Smith, N. Tanaka, D. Tweats, H. Yamasaki, Strategy for genotoxicity testing and stratification of genotoxicity test results—report on initial activities of the IWGT Expert Group, Mutat. Res. 540 (2003) 177–181]. A workgroup devoted to this topic was formed and met on September 9–10, 2005, in San Francisco. This workgroup was devoted to the discussion of when it would be appropriate to conduct additional genetic toxicology studies, as well as what type of studies, if the initial standard battery of tests was negative, but tumor formation was observed in the rodent carcinogenicity assessment. The important role of the standard genetic toxicology testing to determine the mode of action (MOA) for carcinogenesis (genotoxic versus non-genotoxic) was discussed, but the limitations of the standard testing were also reviewed. The workgroup also acknowledged that the entire toxicological profile (e.g. structure–activity relationships, the nature of the tumor finding and metabolic profiles) of a compound needed to be taken into consideration before the conduct of any additional testing. As part of the meeting, case studies were discussed to understand the practical application of additional testing as well as to form a decision tree. Finally, suitable additional genetic toxicology assays to help determine the carcinogenic MOA or establish a weight of evidence (WOE) argument were discussed and formulated into a decision tree. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Rodents
KW - Carcinogens
KW - Carcinogenicity
KW - Genetic toxicology
KW - Toxicology
KW - Carcinogenicity testing
KW - Comet assay
KW - DNA adducts
KW - Genetic toxicology testing
KW - IWGT
KW - Mode of action
KW - Organ-specificity
KW - Transgenic mutation assay
N1 - Accession Number: 23673488; Kasper, Peter 1; Email Address: p.kasper@bfarm.de; Uno, Yoshifumi 2; Mauthe, Robert 3; Asano, Norihide 4; Douglas, George 5; Matthews, Edwin 6; Moore, Martha 7; Mueller, Lutz 8; Nakajima, Madoka 9; Singer, Tim 5; Speit, Guenter 10; Affiliations: 1: Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, D-53175 Bonn, Germany; 2: Toxicology Laboratory, Mitsubishi Pharma Co., Chiba, Japan; 3: Pfizer Global Research and Development, Ann Arbor, MI, USA; 4: Toxicological Research Center, Nitto Denko Corporation, Osaka, Japan; 5: Mutagenesis Section, Health Canada, Ottawa, Canada; 6: Center for Drug Evaluation and Research, US FDA, Silver spring, MD, USA; 7: National Center for Toxicological Research, US FDA, Jefferson, AR, USA; 8: Safety & Technical Sciences, F. Hoffmann-La Roche AG, Basel, Switzerland; 9: Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka, Japan; 10: University of Ulm, Ulm, Germany; Issue Info: Feb2007, Vol. 627 Issue 1, p106; Thesaurus Term: Rodents; Thesaurus Term: Carcinogens; Thesaurus Term: Carcinogenicity; Thesaurus Term: Genetic toxicology; Thesaurus Term: Toxicology; Author-Supplied Keyword: Carcinogenicity testing; Author-Supplied Keyword: Comet assay; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Genetic toxicology testing; Author-Supplied Keyword: IWGT; Author-Supplied Keyword: Mode of action; Author-Supplied Keyword: Organ-specificity; Author-Supplied Keyword: Transgenic mutation assay; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.mrgentox.2006.10.007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yucesoy, Berran
AU - Luster, Michael I.
T1 - Genetic susceptibility in pneumoconiosis
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007/02/05/
VL - 168
IS - 3
M3 - Article
SP - 249
EP - 254
SN - 03784274
AB - Abstract: A large number of cellular mediators such as cytokines, antioxidants and growth factors have been implicated in the pathogenesis of chronic inflammatory and fibrotic diseases. Common functional polymorphisms in these genes have been shown to influence individual susceptibility to these diseases. Silicosis, coal worker pneumoconiosis, progressive massive fibrosis and berylliosis are examples of fibrotic pneumoconiosis and are characterized by irreversible fibrotic lesions in the lung resulting from chronic dust inhalation. Although the materials are the major contributory factors of the disease pathogenesis, not all individuals exposed to similar levels develop disease. This suggests that there is a genetic predisposition to their development. Therefore, an understanding of genetic variability and the interaction between genetic and environmental factors is crucial to the identification of high-risk individuals and prevention and treatment of these diseases. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetics
KW - Lungs -- Dust diseases
KW - Cytokines
KW - Antioxidants
KW - Pneumoconiosis
KW - Susceptibility
N1 - Accession Number: 23740890; Yucesoy, Berran; Email Address: yab7@cdc.gov; Luster, Michael I. 1; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Issue Info: Feb2007, Vol. 168 Issue 3, p249; Thesaurus Term: Genetics; Subject Term: Lungs -- Dust diseases; Subject Term: Cytokines; Subject Term: Antioxidants; Author-Supplied Keyword: Pneumoconiosis; Author-Supplied Keyword: Susceptibility; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.10.021
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Acton, KJ
AU - Burrows, NR
AU - Wang, J
AU - Geiss, LS
T1 - Diagnosed Diabetes Among American Indians and Alaska Natives Aged <35 Years-United States, 1994-2004.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/02/07/
VL - 297
IS - 5
M3 - Article
SP - 461
EP - 462
SN - 00987484
AB - This article focuses on a report by the U.S. Centers for Disease Control that provides an analysis of patient information collected by the Indian Health Service (IHS) during 1994 through 2004 into the incidence of diabetes in Indians and Alaskan natives under the age of 35. Diabetes is known to affect these groups disproportionately. The analysis determined that diabetes prevalence increased from 8.5 to 17.1 per 1,000 population among members of these groups who used IHS health care services. Findings highlight the importance of prevention programs targeted at younger age groups.
KW - DIABETES
KW - ETHNIC groups
KW - DISEASES
KW - NATIVE Americans
KW - EPIDEMIOLOGY
KW - POPULATION research
KW - PUBLIC health research
KW - ALASKA
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States. Indian Health Service
N1 - Accession Number: 23891863; Acton, KJ 1 Burrows, NR Wang, J Geiss, LS 2; Affiliation: 1: Div of Diabetes Treatment and Prevention, Indian Health Service 2: Div of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, CDC.; Source Info: 2/7/2007, Vol. 297 Issue 5, p461; Subject Term: DIABETES; Subject Term: ETHNIC groups; Subject Term: DISEASES; Subject Term: NATIVE Americans; Subject Term: EPIDEMIOLOGY; Subject Term: POPULATION research; Subject Term: PUBLIC health research; Subject Term: ALASKA; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: UNITED States. Indian Health Service; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Ahmad, Syed Rizwanuddin
T1 - Safety of recommended doses of paracetamol.
JO - Lancet
JF - Lancet
Y1 - 2007/02/10/
VL - 369
IS - 9560
M3 - Letter
SP - 462
EP - 463
SN - 00995355
AB - The article presents a letter to the editor in response to the article "Paracetamol: are therapeutic doses entirely safe?," by Rajiv Jalan and colleagues in the December 23/30, 2006 issue.
KW - LETTERS to the editor
KW - ACETAMINOPHEN
N1 - Accession Number: 23981781; Ahmad, Syed Rizwanuddin 1; Email Address: syed.ahmad@fda.hhs.gov; Affiliation: 1: Division of Drug Risk Evaluation, Office of Surveillance and Epidemiology, Food and Drug Administration, Center for Drug Evaluation and Research; Source Info: 2/10/2007, Vol. 369 Issue 9560, p462; Subject Term: LETTERS to the editor; Subject Term: ACETAMINOPHEN; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chilakapati, Jaya
AU - Korrapati, Midhun C.
AU - Hill, Ronald A.
AU - Warbritton, Alan
AU - Latendresse, John R.
AU - Mehendale, Harihara M.
T1 - Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide
JO - Toxicology
JF - Toxicology
Y1 - 2007/02/12/
VL - 230
IS - 2/3
M3 - Article
SP - 105
EP - 116
SN - 0300483X
AB - Abstract: Thioacetamide (TA) is bioactivated by CYP2E1 to TA sulfoxide (TASO), and to the highly reactive sulfdioxide (TASO2), which initiates hepatic necrosis by covalent binding. Previously, we have established that TA exhibits saturation toxicokinetics over a 12-fold dose range, which explains the lack of dose–response for bioactivation-based liver injury. In vivo and in vitro studies indicated that the second step (TASO→TASO2) of TA bioactivation is less efficient than the first one (TA→TASO). The objective of the present study was to specifically test the saturation of the second step of TA bioactivation by directly administering TASO, which obviates the contribution from first step, i.e. TA→TASO. Male SD rats were injected with low (50mg/kg, ip), medium (100mg/kg) and high (LD70, 200mg/kg) doses of TASO. Bioactivation-mediated liver injury that occurs in the initial time points (6 and 12h), estimated by plasma ALT, AST and liver histopathology over a time course, was not dose-proportional. Escalation of liver injury thereafter was dose dependent: low dose injury subsided; medium dose injury escalated upto 36h before declining; high dose injury escalated from 24h leading to 70% mortality. TASO was quantified in plasma by HPLC at various time points after administration of the three doses. With increasing dose (i.e., from 50 to 200mg/kg), area under the curve (AUC) and C max increased more than dose proportionately, indicating that TASO bioactivation exhibits saturable kinetics. Toxicokinetics and initiation of liver injury of TASO are similar to that of TA, although TASO-initiated injury occurs at lower doses. These findings indicate that bioactivation of TASO to its reactive metabolite is saturable in the rat as suggested by previous studies with TA. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER diseases
KW - ACETAMIDE
KW - SULFOXIDES
KW - NECROSIS
KW - Bioactivation
KW - Liver injury
KW - Saturation
KW - Thioacetamide
KW - Thioacetamide sulfoxide
N1 - Accession Number: 23742078; Chilakapati, Jaya 1 Korrapati, Midhun C. 1 Hill, Ronald A. 2 Warbritton, Alan 3 Latendresse, John R. 3 Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliation: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana Monroe, 700 University Avenue, Sugar Hall #306, Monroe, LA 71209-0470, USA 2: Department of Basic Pharmaceutical Sciences, College of Pharmacy, The University of Louisiana Monroe, 700 University Avenue, Sugar Hall #306, Monroe, LA 71209-0470, USA 3: Pathology Associates International, National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Feb2007, Vol. 230 Issue 2/3, p105; Subject Term: LIVER diseases; Subject Term: ACETAMIDE; Subject Term: SULFOXIDES; Subject Term: NECROSIS; Author-Supplied Keyword: Bioactivation; Author-Supplied Keyword: Liver injury; Author-Supplied Keyword: Saturation; Author-Supplied Keyword: Thioacetamide; Author-Supplied Keyword: Thioacetamide sulfoxide; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.tox.2006.11.050
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DB - aph
ER -
TY - JOUR
AU - Curtis, S. K.
AU - Kothary, M. H.
AU - Blodgett, R. J.
AU - Raybourne, R. B.
AU - Ziobro, G. C.
AU - Tall, B. D.
T1 - Rugosity in Grimontia hollisae.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/02/15/
VL - 73
IS - 4
M3 - Article
SP - 1215
EP - 1224
SN - 00992240
AB - Grimontia hollisae, formerly Vibrio hollisae, produces both smooth and rugose colonial variants. The rugose colony phenotype is characterized by wrinkled colonies producing copious amounts of exopolysaccharide. Cells from a rugose colony grown at 30°C form rugose colonies, while the same cells grown at 37°C form smooth colonies, which are characterized by a nonwrinkled, uncrannied appearance. Stress response studies revealed that after exposure to bleach for 30 min, rugose survivors outnumbered smooth survivors. Light scatter information obtained by flow cytometry indicated that rugose cells clumped into clusters of three or more cells (average, five cells) and formed two major clusters, while smooth cells formed only one cluster of single cells or doublets. Fluorescent lectin-binding flow cytometry studies revealed that the percentages of rugose cells that bound either wheat germ agglutinin (WGA) or Galanthus nivalis lectin (GNL) were greater than the percentages of smooth cells that bound the same lectins (WGA, 35% versus 3.5%; GNL, 67% versus 0.21%). These results indicate that the rugose exopolysaccharide consists partially of N-acetylglucosamine and mannose. Rugose colonies produced significantly more biofilm material than did smooth colonies, and rugose colonies grown at 30°C produced more biofilm material than rugose colonies grown at 37°C. Ultrastructurally, rugose colonies show regional cellular differentiation, with apical and lateral colonial regions containing cells embedded in a matrix stained by Alcian Blue. The cells touching the agar surface are packed tightly together in a palisade-like manner. The central region of the colony contains irregularly arranged, fluid-filled spaces and loosely packed chains or arrays of coccoid and vibrioid cells. Smooth colonies, in contrast, are flattened, composed of vibrioid cells, and lack distinct regional cellular differences. Results from suckling mouse studies showed that both orally fed rugose and smooth variants elicited significant, but similar, amounts of fluid accumulated in the stomach and intestines. These observations comprise the first report of expression and characterization of rugosity by G. hollisae and raise the possibility that expression of rugose exopolysaccharide in this organism is regulated at least in part by growth temperature. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO
KW - PHENOTYPE
KW - MICROBIAL exopolysaccharides
KW - CYTOMETRY
KW - WHEAT germ
KW - BIOFILMS
KW - COMMON snowdrop
KW - LECTINS
KW - LIGHT -- Scattering
N1 - Accession Number: 24230008; Curtis, S. K. 1 Kothary, M. H. 2 Blodgett, R. J. 1 Raybourne, R. B. 2 Ziobro, G. C. 1 Tall, B. D. 2; Email Address: ben.tall@fda.hhs.gov.; Affiliation: 1: U.S. Food and Drug Administration, College Park Maryland 20740 2: U.S. Food and Drug Administration, Laurel, Maryland 20708; Source Info: Feb2007, Vol. 73 Issue 4, p1215; Subject Term: VIBRIO; Subject Term: PHENOTYPE; Subject Term: MICROBIAL exopolysaccharides; Subject Term: CYTOMETRY; Subject Term: WHEAT germ; Subject Term: BIOFILMS; Subject Term: COMMON snowdrop; Subject Term: LECTINS; Subject Term: LIGHT -- Scattering; NAICS/Industry Codes: 311211 Flour Milling; Number of Pages: 10p; Illustrations: 5 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.02553-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Voetsch, Andrew C.
AU - Angulo, Frederick J.
AU - Jones, Timothy F.
AU - Moore, Matthew R.
AU - Nadon, Celine
AU - McCarthy, Patrick
AU - Shiferaw, Beletshachew
AU - Megginson, Melanie B.
AU - Hurd, Sharon
AU - Anderson, Bridget J.
AU - Cronquist, Alicia
AU - Vugia, Duc J.
AU - Medus, Carlota
AU - Segler, Suzanne
AU - Graves, Lewis M.
AU - Hoekstra, Robert M.
AU - Griffin, Patricia M.
T1 - Reduction in the Incidence of Invasive Listeriosis in Foodborne Diseases Active Surveillance Network Sites, 1996-2003.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/02/15/
VL - 44
IS - 4
M3 - Article
SP - 513
EP - 520
SN - 10584838
AB - Background. Listeriosis is a leading cause of death among patients with foodborne diseases in the United States. Monitoring disease incidence is an important element of listeriosis surveillance and control. Method. We conducted population-based surveillance for Listeria monocytogenes isolates obtained from normally sterile sites at all clinical diagnostic laboratories in the Foodborne Diseases Active Surveillance Network from 1996 through 2003. Results. The incidence of laboratory-confirmed invasive listeriosis decreased by 24% from 1996 through 2003; pregnancy-associated disease decreased by 37%, compared with a decrease of 23% for patients ⩾50 years old. The highest incidence was reported among Hispanic persons from 1997 through 2001. Differences in incidence by age group and ethnicity may be explained by dietary preferences. Conclusion. The marked decrease in the incidence of listeriosis may be related to the decrease in the prevalence of L. monocytogenes contamination of ready-to-eat foods since 1996. The crude incidence in 2003 of 3.1 cases per 1 million population approaches the government's Healthy People objective of 2.5 cases per 1 million population by 2005. Further decreases in listeriosis incidence will require continued efforts of industry and government to reduce contamination of food and continued efforts to educate consumers and clinicians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Foodborne diseases
KW - Listeriosis
KW - Listeria monocytogenes
KW - Food preferences
KW - United States
N1 - Accession Number: 24511192; Voetsch, Andrew C. 1; Email Address: AVoetsch@cdc.gov; Angulo, Frederick J. 1; Jones, Timothy F. 2; Moore, Matthew R. 3; Nadon, Celine 4; McCarthy, Patrick 5; Shiferaw, Beletshachew 6; Megginson, Melanie B. 7; Hurd, Sharon 8; Anderson, Bridget J. 9; Cronquist, Alicia 10; Vugia, Duc J. 11; Medus, Carlota 12; Segler, Suzanne 13; Graves, Lewis M. 1; Hoekstra, Robert M. 14; Griffin, Patricia M. 1; Affiliations: 1: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; 2: Tennessee Department of Health, Nashville.; 3: Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; 4: Food Safety and Inspection Service, United States Department of Agriculture, Washington D.C.; 5: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington D.C.; 6: Oregon Department of Human Services, Portland.; 7: Maryland Department of Health and Mental Hygiene, Baltimore.; 8: Connecticut Emerging Infection Program, New Haven.; 9: New York State Department of Health, Albany.; 10: Colorado Department of Public Health and Environment, Denver.; 11: California Department of Health Services, Richmond.; 12: Minnesota Department of Health, St. Paul.; 13: Georgia Emerging Infections Program, Atlanta, Georgia.; 14: Biostatistics and Information Management Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.; Issue Info: 2/15/2007, Vol. 44 Issue 4, p513; Thesaurus Term: Bacterial diseases; Thesaurus Term: Foodborne diseases; Subject Term: Listeriosis; Subject Term: Listeria monocytogenes; Subject Term: Food preferences; Subject: United States; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Varma, Jay K.
AU - Samuel, Michael C.
AU - Marcus, Ruthanne
AU - Hoekstra, Robert M.
AU - Medus, Carlota
AU - Segler, Suzanne
AU - Anderson, Bridget J.
AU - Jones, Timothy F.
AU - Shiferaw, Beletshachew
AU - Haubert, Nicole
AU - Megginson, Melanie
AU - McCarthy, Patrick V.
AU - Graves, Lewis
AU - Van Gilder, Thomas
AU - Angulo, Frederick J.
T1 - Listeria monocytogenes Infection from Foods Prepared in a Commercial Establishment: A Case-Control Study of Potential Sources of Sporadic Illness in the United States.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/02/15/
VL - 44
IS - 4
M3 - Article
SP - 521
EP - 528
SN - 10584838
AB - Background. Listeria monocytogenes has been estimated to cause >2500 illnesses and 500 deaths annually in the United States. Efforts to reduce foodborne listeriosis have focused on foods frequently implicated in outbreaks. Potential sources for L. monocytogenes infection not associated with outbreaks remain poorly understood. Methods. The Foodborne Diseases Active Surveillance Network conducts surveillance for culture-confirmed listeriosis at clinical laboratories in 9 states. After excluding outbreak-associated cases, we attempted to enroll eligible case patients with L. monocytogenes infection in a case-control study from 2000 through 2003. Control subjects were recruited through health care providers and were matched to case patients by state, age, and immunosuppression status. Data were collected about exposures occurring in the 4 weeks before specimen collection from the case patients. Results. Of the 249 case patients with L. monocytogenes infection, only 12 (5%) had cases that were associated with outbreaks; 6 other patients were ineligible for other reasons. Of 231 eligible case patients, 169 (73%) were enrolled in the study. We classified 28 case patients as having pregnancy-associated cases. We enrolled 376 control subjects. In multivariable analysis, L. monocytogenes infection was associated with eating melons at a commercial establishment (odds ratio, 2.6; 95% confidence interval, 1.4-5.0) and eating hummus prepared in a commercial establishment (odds ratio, 5.7; 95% confidence interval, 1.7-19.1). Conclusions. Most cases of L. monocytogenes infection were not associated with outbreaks. Reducing the burden of foodborne listeriosis may require interventions directed at retail environments and at foods, such as melons and hummus, that are not commonly recognized as high risk. Because of the severity of listeriosis, pregnant women and other persons at risk may wish to avoid eating these newly implicated foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Listeriosis
KW - Listeria monocytogenes
KW - Immunosuppression
KW - Diseases -- Risk factors
KW - United States
N1 - Accession Number: 24511193; Varma, Jay K. 1,2; Samuel, Michael C. 3; Marcus, Ruthanne 4; Hoekstra, Robert M. 5; Medus, Carlota 6; Segler, Suzanne 7; Anderson, Bridget J. 8; Jones, Timothy F. 9; Shiferaw, Beletshachew 10; Haubert, Nicole 11; Megginson, Melanie 12; McCarthy, Patrick V. 13; Graves, Lewis 2; Van Gilder, Thomas 2; Angulo, Frederick J. 2; Email Address: fangulo@cdc.gov; Affiliations: 1: Epidemic Intelligence Service, US Centers for Disease Control and Prevention, Atlanta, Georgia.; 2: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.; 3: California Emerging Infections Program, Oakland.; 4: Connecticut Emerging Infections Program, New Haven.; 5: Biostatistics and Information Management Branch, Division of Bacterial and Mycotic Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.; 6: Minnesota Department of Health, Minneapolis.; 7: Georgia Emerging Infections Program, Atlanta, Georgia.; 8: New York Department of Health, Albany.; 9: Tennessee Department of Health, Nashville.; 10: Dregon Department of Human Services, Portland.; 11: Colorado Department of Public Health and Environment, Denver.; 12: Maryland Department of Health and Mental Hygiene, Baltimore.; 13: US Food and Drug Administration, College Park, Maryland.; Issue Info: 2/15/2007, Vol. 44 Issue 4, p521; Thesaurus Term: Foodborne diseases; Subject Term: Listeriosis; Subject Term: Listeria monocytogenes; Subject Term: Immunosuppression; Subject Term: Diseases -- Risk factors; Subject: United States; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Botteman, Marc F.
AU - Ozminkowski, Ron J.
AU - Wang, Shaohung
AU - Pashos, Chris L.
AU - Schaefer, Kendyl
AU - Foley, Daniel J.
T1 - Cost Effectiveness of Long-Term Treatment with Eszopiclone for Primary Insomnia in Adults: A Decision Analytical Model.
JO - CNS Drugs
JF - CNS Drugs
Y1 - 2007/02/15/
VL - 21
IS - 4
M3 - Article
SP - 319
PB - Springer Science & Business Media B.V.
SN - 11727047
AB - OBJECTIVE: Although the clinical benefits of pharmacological treatments for insomnia have been studied, no systematic assessment of their economic value has been reported. This analysis assessed, from a broad payer and societal perspective, the cost effectiveness of long-term treatment with eszopiclone (LUNESTA™, Sepracor Inc., [Marlborough, MA, USA]) for chronic primary insomnia in adults in the US. METHODS: A decision analytical model was developed based on the reanalysis of a 6-month placebo-controlled trial, which demonstrated that eszopiclone 3mg significantly improved sleep and daytime function measures versus placebo in adults with primary insomnia. Patients were classified as either having remitted or not remitted from insomnia based upon a composite index of eight sleep and daytime function measures collected during the trial. These data were supplemented with quality-of-life and healthcare and lost productivity cost data from the published literature and medical and absenteeism claims databases. RESULTS: Compared with non-remitted patients, patients classified as remitted had lower monthly healthcare and productivity costs (in 2006 dollars) [a reduction of $US242 and $US182, respectively] and higher quality-adjusted life-year (QALY) weight (a net gain of 0.0810 on a scale ranging from 0 to 1). During the study, eszopiclone-treated patients were about 2.5 times more likely to have remitted than placebo-treated patients. Six months of eszopiclone treatment reduced direct (healthcare) and indirect (productivity) costs by an estimated $US245.13 and $US184.19 per patient, respectively. Eszopiclone use was associated with a cost of $US497.15 per patient over 6 months (including drug cost, dispensing fee, physician visit and time loss to receive care). Thus, after considering the above savings and the costs associated with eszopiclone treatment over 6 months, cost increased by $US252.02 (excluding productivity gains) and $US67.83 (including productivity gains) per person. However, eszopiclone treatment was also associated with a net QALY gain of 0.006831 per patient over the same period. Consequently, the incremental cost per QALY gained associated with eszopiclone was approximately $US9930 (including productivity gains [i.e. $US67.83 ÷ 0.006831]) and $US36 894 (excluding productivity gains [i.e. $US252.02 ÷ 0.006831]). Sensitivity analyses using a variety of scenarios suggested that eszopiclone is generally cost effective. CONCLUSIONS: This analysis suggested that long-term eszopiclone treatment was cost effective over the 6-month study period, particularly when the impact on productivity costs is considered. Given the increasing interest in new pharmacological interventions to manage insomnia, payers and clinicians alike should carefully consider the balance of health and economic benefits that these interventions offer. Accordingly, additional research in this area is warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of CNS Drugs is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPNOTICS
KW - INSOMNIA -- Treatment
KW - MEDICAL care costs
KW - COST effectiveness
KW - COGNITIVE therapy
KW - QUALITY of life
N1 - Accession Number: 25541519; Botteman, Marc F. 1 Ozminkowski, Ron J. 2 Wang, Shaohung 2 Pashos, Chris L. 3 Schaefer, Kendyl 4 Foley, Daniel J. 5; Affiliation: 1: Pharmerit North America LLC, Bethesda, Maryland, USA 2: Thompson Medstat, Ann Arbor, Michigan, USA 3: Abt Associates Inc. - HERQuLES, Lexington, Massachusetts, USA 4: Sepracor Inc., Marlborough, Massachusetts, USA 5: US Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA; Source Info: 2007, Vol. 21 Issue 4, p319; Subject Term: HYPNOTICS; Subject Term: INSOMNIA -- Treatment; Subject Term: MEDICAL care costs; Subject Term: COST effectiveness; Subject Term: COGNITIVE therapy; Subject Term: QUALITY of life; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 16p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eastes, Walter
AU - Baron, Paul A.
AU - Baier, Robert E.
AU - Guldberg, Marianne
AU - Potter, Russell
T1 - Do Vitreous Fibers Break in the Lung?
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2007/02/15/
VL - 19
IS - 4
M3 - Article
SP - 311
EP - 315
SN - 08958378
AB - In order to determine whether breakage of long vitreous fibers in the lung could be responsible for removing significant numbers of these fibers, an intratracheal instillation study was done with a preparation consisting of mostly long fibers of two different types. Following instillation of both fibers, laboratory rats were sacrificed at 6 times up to 14 days. The NK (conventional borosilicate glass) fiber preparation had about 20% short fibers (length ≤ 15 μm) initially, and fibers recovered from the lungs remained at that proportion for the entire 14 days. But the HT (a new rock or stone wool) fiber preparation, which had about 5% short fibers initially, jumped to about 50% short fibers at 2 days and remained at that proportion for the rest of the study. The appearance of many short HT fibers where there were few initially is conclusive evidence that these long fibers break, and it explains their rapid removal from the lung. Since the HT fibers dissolve rapidly at acid pH, but slowly at the near neutral pH of the extracellular lung fluid, it is likely that acid attack by phagocytic cells is causing the long fibers to dissolve and break. The long NK fibers dissolve rapidly at neutral pH but slowly at acid pH and thus appear to clear by more or less uniform dissolution without apparent breakage. The long fibers of these two kinds are removed rapidly at about the same rate, but by a different mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Respiratory organs
KW - Lung diseases
KW - Intratracheal anesthesia
KW - Cardiopulmonary system
KW - Preventive medicine
N1 - Accession Number: 24155162; Eastes, Walter; Email Address: eastes@infinet.com; Baron, Paul A. 1; Baier, Robert E. 2; Guldberg, Marianne 3; Potter, Russell 4; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnatti, OH, USA; 2: State University of New York, Buffalo, Buffalo, New York, USA; 3: Rockwool International A/S, Hedehusene, Denmark; 4: Owens Corning, Granville, Ohio, USA; Issue Info: Feb2007, Vol. 19 Issue 4, p311; Thesaurus Term: Public health; Subject Term: Respiratory organs; Subject Term: Lung diseases; Subject Term: Intratracheal anesthesia; Subject Term: Cardiopulmonary system; Subject Term: Preventive medicine; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/08958370601144530
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Margolis, Todd P.
AU - Imai, Yumi
AU - Li Yang
AU - Vallas, Vicky
AU - Krause, Philip R.
T1 - Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency- Associated Transcripts.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2007/02/15/
VL - 81
IS - 4
M3 - Article
SP - 40
EP - 40
SN - 0022538X
AB - Herpes simplex virus type 1 (HSV-1) and HSV-2 cause very similar acute infections but differ in their abilities to reactivate from trigeminal and dorsal root ganglia. To investigate differences in patterns of viral infection, we colabeled murine sensory ganglia for evidence of HSV infection and for the sensory neuron marker A5 or KH10. During acute infection, 7 to 10% of HSV-1 or HSV-2 antigen-positive neurons were A5 positive and 13 to 16% were KH10 positive, suggesting that both viruses reach each type of neuron in a manner proportional to their representation in uninfected ganglia. In murine trigeminal ganglia harvested during HSV latency, 25% of HSV-1 latency-associated transcript (LAT)- and 4% of HSV-2 LAT-expressing neurons were A5 positive, while 12% of HSV-1 LAT- and 42% of HSV-2 LAT-expressing neurons were KH10 positive. A similar difference was observed in murine dorsal root ganglia. These differences could not be attributed to differences in LAT expression levels in A5- versus KH10-positive neurons. Thus, HSV-1 demonstrated a preference for the establishment of latency in A5-positive neurons, while HSV-2 demonstrated a preference for the establishment of latency in KH10-positive neurons. A chimeric HSV-2 mutant that expresses the HSV-1 LAT exhibited an HSV-1 phenotype, preferentially establishing latency in A5-positive neurons. These data imply that the HSV-1 and HSV-2 LAT regions influence the ability of virus to establish latency in different neuronal subtypes. That the same chimeric virus has a characteristic HSV-1 reactivation phenotype further suggests that LAT-influenced establishment of latency in specific neuronal subtypes could be an important part of the mechanism by which LAT influences viral reactivation phenotypes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - SENSORY ganglia
KW - VIRUS diseases
KW - INFECTION
KW - NEURONS
N1 - Accession Number: 24097474; Margolis, Todd P. 1,2; Email Address: todd.margolis@ucsf.edu Imai, Yumi 1 Li Yang 1 Vallas, Vicky 1 Krause, Philip R. 3; Affiliation: 1: F. I. Proctor Foundation, University of California, San Francisco, 95 Kirkham, San Francisco, California 94143 2: Department of Ophthalmology, University of California, San Francisco, 95 Kirkham, San Francisco, California 94143 3: Food and Drug Administration/Center for Biologics Evaluation and Research, HFM 457, 29 Lincoln Drive, Building 29A, Room C16, Bethesda, Maryland 20892-4555; Source Info: Feb2007, Vol. 81 Issue 4, p40; Subject Term: HERPES simplex virus; Subject Term: SENSORY ganglia; Subject Term: VIRUS diseases; Subject Term: INFECTION; Subject Term: NEURONS; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.02110-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klaschik, Sven
AU - Gursel, Ihsan
AU - Klinman, Dennis M.
T1 - CpG-mediated changes in gene expression in murine spleen cells identified by microarray analysis
JO - Molecular Immunology
JF - Molecular Immunology
Y1 - 2007/02/15/
VL - 44
IS - 6
M3 - Article
SP - 1095
EP - 1104
SN - 01615890
AB - Abstract: Unmethylated CpG motifs interact with Toll-like receptor 9 (TLR9), triggering an innate immune response characterized by the production of cytokines, chemokines and immunoglobulins. Microarray analysis of cDNA from murine spleen cells stimulated with CpG oligodeoxynucleotides (ODN) identified reproducible changes in gene expression over time. Eight genes are significantly up-regulated 2h post CpG ODN stimulation, most of which contribute to the induction of innate or adaptive immune responses. Network analysis indicates that TNF and NFKB1 are key regulators of gene expression at this early time point. At 4h, IL1B in addition to TNF and NFKB1 play dominant roles in the up-regulation of immune gene expression, whereas by 8h this function is mediated by TNF, IFNG, and MYC. Genes responsible for down-regulating CpG-induced responses were also identified, dampening what would otherwise be a continuous positive feedback loop. This work provides novel insights into the regulatory process embedded in the gene expression profile induced by CpG ODN, identifies novel genes associated with CpG-induced immune stimulation, and clarifies the breadth of the immune response elicited via TLR9. [Copyright &y& Elsevier]
AB - Copyright of Molecular Immunology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC regulation
KW - GENE expression
KW - MOLECULAR biology
KW - LYMPHOID tissue
KW - CpG oligodeoxynucleotides
KW - Gene regulation
KW - Inflammation
KW - Molecular biology
N1 - Accession Number: 22506005; Klaschik, Sven 1 Gursel, Ihsan 1 Klinman, Dennis M.; Email Address: dennis.klinman@fda.hhs.gov; Affiliation: 1: Section of Retroviral Research, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Room 3D10, Bethesda, MD 20892, USA; Source Info: Feb2007, Vol. 44 Issue 6, p1095; Subject Term: GENETIC regulation; Subject Term: GENE expression; Subject Term: MOLECULAR biology; Subject Term: LYMPHOID tissue; Author-Supplied Keyword: CpG oligodeoxynucleotides; Author-Supplied Keyword: Gene regulation; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Molecular biology; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.molimm.2006.07.283
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jacek Cielak
AU - Jon S. Kauffman
AU - Michelle J. Kolodziejski
AU - John R. Lloyd
AU - Serge L. Beaucage
T1 - Assessment of 4-Nitrogenated Benzyloxymethyl Groups for 2‘-Hydroxyl Protection in Solid-Phase RNA Synthesis.
JO - Organic Letters
JF - Organic Letters
Y1 - 2007/02/15/
VL - 9
IS - 4
M3 - Article
SP - 671
EP - 674
SN - 15237060
AB - The search for a 2‘-OH protecting group that would impart ribonucleoside phosphoramidites with coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites led to an assessment of 2‘-O-(4-nitrogenated benzyloxy)methyl groups through solid-phase RNA synthesis using phosphoramidites 2a−d, 12a, and 14a. These phosphoramidites exhibited rapid and efficient coupling properties. Particularly noteworthy is the cleavage of the 2‘-O-4-(N-methylamino)benzyloxymethyl groups in 0.1 M AcOH, which led to U19dT within 15 min at 90 °C. [ABSTRACT FROM AUTHOR]
AB - Copyright of Organic Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYL groups
KW - RNA synthesis
KW - DEOXYRIBONUCLEASES
KW - COUPLINGS (Gearing)
N1 - Accession Number: 25520848; Jacek Cielak 1 Jon S. Kauffman 1 Michelle J. Kolodziejski 1 John R. Lloyd 1 Serge L. Beaucage 1; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research,Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892,Lancaster Laboratories, 2425 New Holland Pike, Lancaster, Pennsylvania 17605, andLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive andKidney Diseases, The National Institutes of Health, 9000 Rockville Pike,Bethesda, Maryland 20892; Source Info: Feb2007, Vol. 9 Issue 4, p671; Subject Term: METHYL groups; Subject Term: RNA synthesis; Subject Term: DEOXYRIBONUCLEASES; Subject Term: COUPLINGS (Gearing); NAICS/Industry Codes: 333613 Mechanical Power Transmission Equipment Manufacturing; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chilakapati, Jaya
AU - Korrapati, Midhun C.
AU - Shankar, Kartik
AU - Hill, Ronald A.
AU - Warbritton, Alan
AU - Latendresse, John R.
AU - Mehendale, Harihara M.
T1 - Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/02/15/
VL - 219
IS - 1
M3 - Article
SP - 72
EP - 84
SN - 0041008X
AB - Abstract: Thioacetamide (TA) undergoes saturation toxicokinetics in ad libitum (AL) fed rats. Diet restriction (DR) protects rats from lethal dose of TA despite increased bioactivation-mediated liver injury via CYP2E1 induction. While a low dose (50 mg TA/kg) produces 6-fold higher initial injury, a 12-fold higher dose produces delayed and mere 2.5-fold higher injury. The primary objective was to determine if this less-than-expected increase in injury is due to saturation toxicokinetics. Rats on AL and DR for 21 days received either 50 or 600 mg TA/kg i.p. T 1/2 and AUCs for TA and TA-S-oxide were consistent with saturable kinetics. Covalent binding of 14C-TA-derived-radiolabel to liver macromolecules after low dose was 2-fold higher in DR than AL rats. However, following lethal dose, no differences were found between AL and DR. This lack of dose-dependent response appears to be due to saturation of bioactivation at the higher dose. The second objective was to investigate the effect of phenobarbital pretreatment (PB) on TA-initiated injury following a sub-lethal dose (500 mg/kg). PB induced CYP2B1/2 ∼350-fold, but did not increase covalent binding of 14C-TA, TA-induced liver injury and mortality, suggesting that CYP2B1/2 has no major role in TA bioactivation. The third objective was to investigate the role of CYP2E1 using cyp2e1 knockout mice (KO). Injury was assessed over time (0–48 h) in wild type (WT) and KO mice after LD100 dose (500 mg/kg) in WT. While WT mice exhibited robust injury which progressed to death, KO mice exhibited neither initiation nor progression of injury. These findings confirm that CYP2E1 is responsible for TA bioactivation. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450 CYP2E1
KW - BIOTRANSFORMATION (Metabolism)
KW - ACETAMIDE
KW - LIVER diseases
KW - cyp2e1 knockouts
KW - Diet restriction
KW - Liver injury
KW - Phenobarbital
KW - Thioacetamide
N1 - Accession Number: 24148124; Chilakapati, Jaya 1 Korrapati, Midhun C. 1 Shankar, Kartik 2 Hill, Ronald A. 3 Warbritton, Alan 4 Latendresse, John R. 4 Mehendale, Harihara M. 1; Email Address: mehendale@ulm.edu; Affiliation: 1: Department of Toxicology, College of Pharmacy, The University of Louisiana Monroe, 700 University Avenue, Sugar Hall # 306, Monroe, LA 71209-0470, USA 2: Arkansas Children’s Nutrition Center, Little Rock, AR, USA 3: Division of Basic Pharmaceutical Sciences (R.A.H.), College of Pharmacy, The University of Louisiana Monroe, Monroe, LA, USA 4: Pathology Associates International, National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Feb2007, Vol. 219 Issue 1, p72; Subject Term: CYTOCHROME P-450 CYP2E1; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: ACETAMIDE; Subject Term: LIVER diseases; Author-Supplied Keyword: cyp2e1 knockouts; Author-Supplied Keyword: Diet restriction; Author-Supplied Keyword: Liver injury; Author-Supplied Keyword: Phenobarbital; Author-Supplied Keyword: Thioacetamide; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.taap.2006.11.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24148124&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yiping Jia
AU - Buehler, Paul W.
AU - Boykins, Robert A.
AU - Venable, Richard M.
AU - Alayash, Abdu I.
T1 - Structural Basis of Peroxide-mediated Changes in Human Hemoglobin.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2007/02/16/
VL - 282
IS - 7
M3 - Article
SP - 4894
EP - 4907
SN - 00219258
AB - Hydrogen peroxide (H2O2) triggers a redox cycle between ferric and ferry! hemoglobin (Hb) leading to the formation of a transient protein radical and a covalent hemeprotein cross-link. Addition of H2O2 to highly purified human hemoglobin (HbA0) induced structural changes that primarily resided within β subunits followed by the internalization of the heme moiety within β subunits. These modifications were observed when an equal molar concentration of H2O2 was added to HbA0 yet became more abundant with greater concentrations of H2O2. Mass spectrometric and amino acid analysis revealed for the first time that βCys-93 and βCys-112 were oxidized extensively and irreversibly to cysteic acid when HbA0 was treated with H2O2. Oxidation of further amino acids in HbA0 exclusive to the β-globin chain included modification of βTrp-15 to oxyindoly! and kynureninyl products as well as βMet-55 to methionine sulfoxide. These findings may therefore explain the premature collapse of the β subunits as a result of the H2O2 attack. Analysis of a tryptic digest of the main reversed phase-high pressure liquid chromatography fraction revealed two α-peptide fragments (α128 - α139) and a heme moiety with the loss of iron, cross-linked between αSer-138 and the porphyrin ring. The novel oxidative pathway of HbA0 modification detailed here may explain the diverse oxidative, toxic, and potentially immunogenic effects associated with the release of hemoglobin from red blood cells during hemolytic diseases and/or when cell-free Hb is used as a blood substitute. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - PEROXIDES
KW - OXIDATION-reduction reaction
KW - BLOOD proteins
KW - SPECTRUM analysis
KW - AMINO acids
N1 - Accession Number: 25527401; Yiping Jia 1 Buehler, Paul W. 1 Boykins, Robert A. 2 Venable, Richard M. 3 Alayash, Abdu I. 1; Email Address: abdu.alayash@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Food and Drug Administration, Bethesda, Maryland 2: Laboratory of Biophysics, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 3: Membrane Biophysics Section, Laboratory of Computational Biology, NHLBI, National Institutes of Health, Bethesda, Maryland; Source Info: 2/16/2007, Vol. 282 Issue 7, p4894; Subject Term: HEMOGLOBIN; Subject Term: PEROXIDES; Subject Term: OXIDATION-reduction reaction; Subject Term: BLOOD proteins; Subject Term: SPECTRUM analysis; Subject Term: AMINO acids; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 14p; Illustrations: 1 Diagram, 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1074/jbc.M609955200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Agrawal, Anoop
AU - Cronin, John
AU - Tonazzi, Juan
AU - McCleskey, T. Mark
AU - Burrell, Anthony K.
AU - Ehler, Deborah S.
T1 - Ultra-trace determination of beryllium in occupational hygiene samples by ammonium bifluoride extraction and fluorescence detection using hydroxybenzoquinoline sulfonate
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2007/02/19/
VL - 584
IS - 2
M3 - Article
SP - 281
EP - 286
SN - 00032670
AB - Abstract: A highly sensitive molecular fluorescence method for measuring ultra-trace levels of beryllium has been previously described. The method entails extraction of beryllium workplace samples by 1% ammonium bifluoride (NH4HF2, aqueous), followed by fluorescence detection using hydroxybenzoquinoline sulfonate (HBQS). In this work, modification of the existing procedure resulted in a significant improvement in detection power, thereby enabling ultra-trace determination of beryllium in air filter and surface wipe samples. Such low detection limits may be necessary in view of expected decreases in applicable occupational exposure limits (OELs) for beryllium. Attributes of the modified NH4HF2 extraction/HBQS fluorescence method include method detection limits (MDLs) of <0.8ng to ≈2ng Be per sample (depending on the fluorometer used), quantitative recoveries from beryllium oxide, a dynamic range of several orders of magnitude, and freedom from interferences. Other key advantages of the technique are field portability, relatively low cost, and high sample throughput. The method performance compares favorably with that of inductively coupled plasma-mass spectrometry (ICP-MS). [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRACE analysis
KW - BERYLLIUM
KW - AMMONIUM compounds
KW - EXTRACTION (Chemistry)
KW - Air monitoring
KW - Beryllium
KW - Extraction
KW - Fluorescence
KW - Trace analysis
KW - Workplace
N1 - Accession Number: 23868396; Ashley, Kevin 1; Email Address: kashley@cdc.gov Agrawal, Anoop 2 Cronin, John 2 Tonazzi, Juan 2 McCleskey, T. Mark 3 Burrell, Anthony K. 3 Ehler, Deborah S. 3; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, M.S. R-7, Cincinnati, OH 45226-1998, USA 2: Berylliant, Inc., 4541 E. Fort Lowell Road, Tucson, AZ 85712, USA 3: Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545, USA; Source Info: Feb2007, Vol. 584 Issue 2, p281; Subject Term: TRACE analysis; Subject Term: BERYLLIUM; Subject Term: AMMONIUM compounds; Subject Term: EXTRACTION (Chemistry); Author-Supplied Keyword: Air monitoring; Author-Supplied Keyword: Beryllium; Author-Supplied Keyword: Extraction; Author-Supplied Keyword: Fluorescence; Author-Supplied Keyword: Trace analysis; Author-Supplied Keyword: Workplace; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.aca.2006.11.066
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yue, Hongfei
AU - Jansen, Susan A.
AU - Strauss, Kenneth I.
AU - Borenstein, Michael R.
AU - Barbe, Mary F.
AU - Rossi, Luella J.
AU - Murphy, Elise
T1 - A liquid chromatography/mass spectrometric method for simultaneous analysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids in rat brain tissue
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/02/19/
VL - 43
IS - 3
M3 - Article
SP - 1122
EP - 1134
SN - 07317085
AB - Abstract: A sensitive, specific, and robust liquid chromatography/mass spectrometric (LC/MS) method was developed and validated that allows simultaneous analysis of arachidonic acid (AA) and its cyclooxygenase, cytochrome P450, and lipoxygenase pathway metabolites prostaglandins (PGs), dihydroxyeicosatrienoic acids (DiHETrEs), hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs), including PGF2α, PGE2, PGD2, PGJ2, 14,15-DiHETrE, 11,12-DiHETrE, 8,9-DiHETrE, 5,6-DiHETrE, 20-HETE, 15-HETE, 12-HETE, 9-HETE, 8-HETE, 5-HETE, 14,15-EET, 11,12-EET, 8,9-EET, and 5,6-EET in rat brain tissues. Deuterium labeled PGF2α-d4, PGD2-d4, 15(S)-HETE-d8, 14,15-EET-d8, 11,12-EET-d8, 8,9-EET-d8, and AA-d8 were used as internal standards. Solid phase extraction was used for sample preparation. A gradient LC/MS method using a C18 column and electrospray ionization source under negative ion mode was optimized for the best sensitivity and separation within 35min. The method validation, including LC/MS instrument qualification, specificity, calibration model, accuracy, precision (without brain matrix and with brain matrix), and extraction efficiency were performed. The linear ranges of the calibration curves were 2–1000pg for PGs, DiHETrEs, HETEs, and EETs, 10–2400pg for PGE2 and PGD2, and 20–2000ng for AA, respectively. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARACHIDONIC acid
KW - LIQUID chromatography
KW - PROSTAGLANDINS
KW - HYDROGEN isotopes
KW - Arachidonic acid
KW - Brain tissue
KW - Dihydroxyeicosatrienoic acids (DiHETrEs)
KW - Epoxyeicosatrienoic acids (EETs)
KW - Hydroxyeicosatetraenoic acids (HETEs)
KW - LC/MS
KW - Prostaglandins (PGs)
N1 - Accession Number: 23867007; Yue, Hongfei 1 Jansen, Susan A. 1; Email Address: suebee@temple.edu Strauss, Kenneth I. 2 Borenstein, Michael R. 3 Barbe, Mary F. 4 Rossi, Luella J. 5 Murphy, Elise 5; Affiliation: 1: Temple University, Chemistry Department, Analytical Chemistry, 1901 North 13th Street, Philadelphia, PA 19122, USA 2: University of Cincinnati, ML515 College of Medicine, Department of Neurosurgery, 231 Albert Sabin Way, Cincinnati, OH 45267-0515, USA 3: Temple University, School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA 4: Temple University, Department of Physical Therapy, Anatomy and Cell Biology, 3307 North Broad Street, Philadelphia, PA 19140, USA 5: U.S. Food and Drug Administration, 2nd and Chestnut Street, Philadelphia, PA 19106, USA; Source Info: Feb2007, Vol. 43 Issue 3, p1122; Subject Term: ARACHIDONIC acid; Subject Term: LIQUID chromatography; Subject Term: PROSTAGLANDINS; Subject Term: HYDROGEN isotopes; Author-Supplied Keyword: Arachidonic acid; Author-Supplied Keyword: Brain tissue; Author-Supplied Keyword: Dihydroxyeicosatrienoic acids (DiHETrEs); Author-Supplied Keyword: Epoxyeicosatrienoic acids (EETs); Author-Supplied Keyword: Hydroxyeicosatetraenoic acids (HETEs); Author-Supplied Keyword: LC/MS; Author-Supplied Keyword: Prostaglandins (PGs); Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.jpba.2006.10.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23867007&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Osorio, Manuel
AU - Bray, Mechelle D.
AU - Walker, Richard I.
T1 - Vaccine potential for inactivated shigellae
JO - Vaccine
JF - Vaccine
Y1 - 2007/02/19/
VL - 25
IS - 9
M3 - Article
SP - 1581
EP - 1592
SN - 0264410X
AB - Abstract: We used human monocyte-derived dendritic cells (DC) and Balb/c mice as models to establish the immunogenic and protective potential of formalin-inactivated Shigella spp. Incubation of DC with inactivated or live bacteria induced DC maturation and cytokine release. Mice immunized orally or intranasally with killed S. flexneri, S. sonnei, or S. dysenteriae developed IgG and fecal IgA titers to the homologous LPS. Following respiratory challenge with the live homologous organisms, 80–100% survival was seen in all vaccinated groups compared to negligible survival in mice given PBS. Oral or intranasal immunization with an inactivated S. flexneri 2a strain (CVD1203) expressing the CFA/I and CS3 antigens of enterotoxigenic Escherichia coli induced IgG responses to both heterologous antigens. These in vivo and in vitro data indicate that inactivated shigellae retain the ability to interact effectively with key antigen presenting cells and induce protective immune responses in mice. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Immune response
KW - Drug development
KW - Shigellosis
KW - Dendritic cells
KW - Enteric vaccines
KW - Inactivated bacteria
N1 - Accession Number: 23742004; Osorio, Manuel 1; Bray, Mechelle D. 1; Walker, Richard I.; Email Address: Richard.Walker@fda.hhs.gov; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, United States; Issue Info: Feb2007, Vol. 25 Issue 9, p1581; Thesaurus Term: Escherichia coli; Thesaurus Term: Immune response; Subject Term: Drug development; Subject Term: Shigellosis; Author-Supplied Keyword: Dendritic cells; Author-Supplied Keyword: Enteric vaccines; Author-Supplied Keyword: Inactivated bacteria; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.11.012
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McMullan, Laura K.
AU - Grakoui, Arash
AU - Evans, Matthew J.
AU - Mihalik, Kathleen
AU - Puig, Montserrat
AU - Branch, Andrea D.
AU - Feinstone, Stephen M.
AU - Rice, Charles M.
T1 - Evidence for a functional RNA element in the hepatitis C virus core gene.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/02/20/
VL - 104
IS - 8
M3 - Article
SP - 2879
EP - 2884
SN - 00278424
AB - In the core protein-coding region of hepatitis C virus (HCV), evidence exists for both phylogenetically conserved RNA structures and a +1 alternative reading frame (ARF). To investigate its role in HCV infection, we introduced four stop codons into the ARF of a genotype 1 a H77 molecular clone. The changes did not alter the core protein sequence, but were predicted to disrupt RNA secondary structures. An attenuated infection was established after inoculation of the mutant HCV RNA into an HCV naïve chimpanzee. The acute infection was atypical with low peak viremia, minimal alanine aminotransferase elevation, and early virus control by a diverse adaptive immune response. Sequencing circulating virus revealed progressive reversions at the third and then fourth stop codon. In cell culture, RNA replication of a genome with four stop codons was severely impaired. In contrast, the revertant genome exhibited only a 5-fold reduction in replication. Genomes harboring only the first two stop codons replicated to WT levels. Similarly, reversions at stop codons 3 and 4, which improved replication, were selected with recombinant, infectious HCV in cell culture. We conclude that ARF-encoded proteins initiating at the polyprotein AUG are not essential for HCV replication in cell culture or in vivo. Rather, our results provide evidence for a functionally important RNA element in the ARF region. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - RNA
KW - CHIMPANZEES
KW - AMINOTRANSFERASES
KW - CELL culture
KW - alternative reading frame
KW - RNA replication
KW - RNA structure
N1 - Accession Number: 24357626; McMullan, Laura K. 1 Grakoui, Arash 2 Evans, Matthew J. 1 Mihalik, Kathleen 3 Puig, Montserrat 3 Branch, Andrea D. 4 Feinstone, Stephen M. 3 Rice, Charles M. 1; Affiliation: 1: Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10021 2: Department of Medicine, Microbiology, and Immunology, Emory Vaccine Center, Atlanta, GA 3: Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 4: Division of Liver Disease, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; Source Info: 2/20/2007, Vol. 104 Issue 8, p2879; Subject Term: HEPATITIS C virus; Subject Term: RNA; Subject Term: CHIMPANZEES; Subject Term: AMINOTRANSFERASES; Subject Term: CELL culture; Author-Supplied Keyword: alternative reading frame; Author-Supplied Keyword: RNA replication; Author-Supplied Keyword: RNA structure; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1073/pnas.0611267104
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doerge, Daniel R.
AU - Twaddle, Nathan C.
AU - Boettcher, Melanie I.
AU - McDaniel, L. Patrice
AU - Angerer, Jürgen
T1 - Urinary excretion of acrylamide and metabolites in Fischer 344 rats and B6C3F1 mice administered a single dose of acrylamide
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007/02/28/
VL - 169
IS - 1
M3 - Article
SP - 34
EP - 42
SN - 03784274
AB - Abstract: Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in mice and rats. AA is also formed during cooking in many commonly consumed starchy foods. Our previous toxicokinetic investigations of AA and its genotoxic metabolite, glycidamide (GA), in rodents showed that AA is highly bioavailable from oral routes of administration, is widely distributed to tissues, and that the dietary route, in particular, favors metabolism to GA. Formation and accumulation of mutagenic GA–DNA adducts in many tissues support the hypothesis that AA is carcinogenic in rodent bioassays through metabolism to GA. The current investigation describes the quantification of 24h urinary metabolites, including free AA and GA and their mercapturic acid conjugates (AAMA and GAMA, respectively), using LC/MS/MS in F344 rats and B6C3F1 mice following a dose of 0.1mg/kg bw given by intravenous, gavage, and dietary routes of administration. Similar groups of rodents were used previously for serum/tissue toxicokinetic and adduct determinations (DNA and hemoglobin). The goal was to investigate relationships between urinary and circulating biomarkers of exposure, toxicokinetic parameters for AA and GA, and tissue GA–DNA adducts in rodents from single doses of AA. Significant linear correlations were observed between urinary levels of AA with AAMA and GA with GAMA in the current data sets for rats and mice. Concentrations of AA and AAMA correlated significantly with average AUC values determined previously for AA in groups of rats and mice similarly dosed with AA. Urinary GA and GAMA concentrations showed significant correlations with average AUC values for GA and liver GA–DNA adducts determined previously in rats and mice similarly dosed with AA. Despite statistical significance, considerable inter-animal variability was observed in all urinary measurements, which limited the degree of correlation with either average toxicokinetic or biomarker data collected from different groups of animals. These results suggest that urinary measurements of AA and its metabolites may be useful for prediction of internal exposures to AA and GA. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acrylamide
KW - Germ cells
KW - DNA
KW - Hemoglobin
KW - Biomarkers
KW - Glycidamide
KW - Mass spectrometry
KW - Urine
N1 - Accession Number: 23948097; Doerge, Daniel R. 1; Email Address: daniel.doerge@fda.hhs.gov; Twaddle, Nathan C. 1; Boettcher, Melanie I. 2; McDaniel, L. Patrice 1; Angerer, Jürgen 2; Affiliations: 1: National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States; 2: Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstrasse 25/29, D-91054 Erlangen, Germany; Issue Info: Feb2007, Vol. 169 Issue 1, p34; Thesaurus Term: Acrylamide; Thesaurus Term: Germ cells; Subject Term: DNA; Subject Term: Hemoglobin; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Glycidamide; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Urine; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.toxlet.2006.12.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Guang X. Chen
AU - E. Lynn Jenkins
T1 - Potential work‐related bloodborne pathogen exposures by industry and occupation in the United States Part I: An emergency department‐based surveillance studyThe findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.This article is a US government work and, as such, is in the public domain in the United States of America.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/03//
VL - 50
IS - 3
M3 - Article
SP - 183
EP - 190
SN - 02713586
AB - Since the early 1990s, researchers have attempted to assess the magnitude of potential work‐related bloodborne pathogen (BBP) exposures in the U.S. The only data‐derived estimate of 385,000 needlestick and other sharps injuries per year was reported in 2004. The estimate was derived from a convenience sample and did not include exposures outside of hospitals. This study seeks to understand the magnitude and distribution of the exposures across all industries and occupations.Data were from the 1998 to 2000 National Electronic Injury Surveillance System (NEISS), a stratified probability‐based sample of U.S. hospital emergency departments (EDs). NEISS covers all industries and occupations. National estimates of exposures and exposure rates (the number of exposures/1,000 full‐time equivalents (FTE)) were computed.An estimated 78,100 potential work‐related exposures to BBP were treated in hospital EDs annually in the U.S. While hospitals accounted for 75% of all these exposures, 11 other industries had a substantial number of exposures. While registered nurses accounted for 36% of all exposures, 13 other occupations had a substantial number of exposures. Hospitals had the highest exposure rate of 11.3/1,000 FTE, followed by nursing homes (2.8), and residential care facilities without nursing (1.9). Registered nurses had the highest exposure rate of 15.3/1,000 FTE, followed by clinical laboratory technologists and technicians (13.9), and physicians (7.1).While this study begins to more completely describe the problem of potential BBP exposure in the workplace, it is but a first step in further understanding the complex issues surrounding workplace BBP exposures. Am. J. Ind. Med. 50: 183–190, 2007. Published 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases -- Transmission
KW - Bloodborne infections
KW - Work environment
KW - United States
N1 - Accession Number: 24514674; Guang X. Chen 1; E. Lynn Jenkins 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Mar2007, Vol. 50 Issue 3, p183; Thesaurus Term: Communicable diseases -- Transmission; Subject Term: Bloodborne infections; Subject Term: Work environment; Subject: United States; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Grace M.
AU - Murphy, Trudy V.
AU - Lett, Susan
AU - Cortese, Margaret M.
AU - Kretsinger, Katrina
AU - Schauer, Stephanie
AU - Lieu, Tracy A.
T1 - Cost Effectiveness of Pertussis Vaccination in Adults
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2007/03//
VL - 32
IS - 3
M3 - Article
SP - 186
EP - 193
SN - 07493797
AB - Background: Prior economic analyses have reached disparate conclusions about whether vaccinating adults against pertussis would be cost effective. Newly available data on pertussis incidence were used to evaluate the cost effectiveness of one-time adult vaccination and adult vaccination with decennial boosters. Methods: A Markov model was used to calculate the health benefits, risks, costs, and cost effectiveness of the following strategies: (1) no adult pertussis vaccination, (2) one-time adult vaccination at 20–64 years, and (3) adult vaccination with decennial boosters. The impact of the severity of pertussis illness, vaccine adverse events, and herd immunity on model outcomes were also examined. Results: At a disease incidence of 360 per 100,000, the one-time adult vaccination strategy would prevent 2.8 million cases, and the decennial vaccination strategy would prevent 8.3 million cases. As disease incidence varied from 10 to 500 per 100,000, the one-time adult vaccination strategy was projected to prevent 79,000 to 3.8 million adult pertussis cases, while the decennial vaccination program would prevent 239,000 to 11.4 million cases. A one-time adult vaccination strategy would result in 106 million people vaccinated, or approximately 64% of the adult cohort, for a total program cost of $2.1 billion, while a decennial vaccination strategy would cost $6.7 billion. The one-time and decennial booster vaccination strategies result in cost-effectiveness ratios of <$50,000 per quality-adjusted life year saved if disease incidence in adults were greater than 120 cases per 100,000 population. Conclusions: Routine vaccination of adults aged 20 to 64 years with combined tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis is cost effective if pertussis incidence in this age group is greater than 120 per 100,000 population. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WHOOPING cough -- Vaccination
KW - VACCINATION
KW - COST effectiveness
KW - MEDICAL care costs
N1 - Accession Number: 23972568; Lee, Grace M. 1,2; Email Address: grace_lee@hphc.org Murphy, Trudy V. 3 Lett, Susan 4 Cortese, Margaret M. 3,5 Kretsinger, Katrina 3,5 Schauer, Stephanie 4 Lieu, Tracy A. 1,6; Affiliation: 1: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 2: Division of Infectious Diseases, Boston, Massachusetts 3: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 4: Children’s Hospital Boston, Massachusetts Department of Public Health, Boston, Massachusetts 5: U.S. Public Health Service Commissioned Corps, Atlanta, Georgia 6: Division of General Pediatrics, Boston, Massachusetts; Source Info: Mar2007, Vol. 32 Issue 3, p186; Subject Term: WHOOPING cough -- Vaccination; Subject Term: VACCINATION; Subject Term: COST effectiveness; Subject Term: MEDICAL care costs; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.amepre.2006.10.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23972568&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stayner, Leslie
AU - Bena, James
AU - Sasco, Annie J.
AU - Smith, Randall
AU - Steenland, Kyle
AU - Kreuzer, Michaela
AU - Straif, Kurt
T1 - Lung Cancer Risk and Workplace Exposure to Environmental Tobacco Smoke.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2007/03//
VL - 97
IS - 3
M3 - Article
SP - 545
EP - 551
PB - American Public Health Association
SN - 00900036
AB - Objectives. We sought to quantitatively evaluate the association between workplace environmental tobacco smoke exposure and lung cancer. Methods. We performed a meta-analysis in 2003 of data from 22 studies from multiple locations worldwide of workplace environmental tobacco smoke exposure and lung cancer risk. Estimates of relative risk from these studies were analyzed by fitting the data to fixed and mixed effects models. Analyses of highly exposed workers and of the relationship between duration of exposure and lung cancer were also performed. Results. The meta-analysis indicated a 24% increase in lung cancer risk (relative risk [RR]=1.24; 95% confidence interval [CI]=1.18, 1.29) among workers exposed to environmental tobacco smoke. A 2-fold increased risk (RR=2.01; 95% CI=1.33, 2.60) was observed for workers classified as being highly exposed to environmental tobacco smoke. A strong relationship was observed between lung cancer and duration of exposure to environmental tobacco smoke. Conclusions. The findings from this investigation provide the strongest evidence to date that exposure to environmental tobacco smoke in the workplace is associated with an increased risk of lung cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMOKING in the workplace
KW - LUNGS -- Cancer
KW - DISEASES -- Risk factors
KW - META-analysis
KW - QUANTITATIVE research
KW - PASSIVE smoking
N1 - Accession Number: 24347132; Stayner, Leslie 1; Email Address: lstayner@uic.edu Bena, James 2 Sasco, Annie J. 3 Smith, Randall 4 Steenland, Kyle 5 Kreuzer, Michaela 6 Straif, Kurt 7; Affiliation: 1: School of Public Health, Division of Epidemiology and Biostatistics, University of Illinois, Chicago 2: Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, Ohio 3: Victor Ségalen Bordeaux 2 University, Cancer Group, Bordeaux, France 4: National Institute for Occupational Safety and Health, Cincinnati, Ohio 5: Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Ga. 6: Gesellschaft für Strahlenforschung-National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany 7: The International Agency for Research on Cancer, Lyons, France; Source Info: Mar2007, Vol. 97 Issue 3, p545; Subject Term: SMOKING in the workplace; Subject Term: LUNGS -- Cancer; Subject Term: DISEASES -- Risk factors; Subject Term: META-analysis; Subject Term: QUANTITATIVE research; Subject Term: PASSIVE smoking; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article; Full Text Word Count: 6229
L3 - 10.2105/AJPH.2004.061275
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Mengel, M.
AU - Chapman, J. R.
AU - Cosio, F. G.
AU - Cavaillé-Coll, M. W.
AU - Haller, H.
AU - Halloran, P. F.
AU - Kirk, A. D.
AU - Mihatsch, M. J.
AU - Nankivell, B. J.
AU - Racusen, L. C.
AU - Roberts, I. S.
AU - Rush, D. N.
AU - Schwarz, A.
AU - Serón, D.
AU - Stegall, M. D.
AU - Colvin, R. B.
T1 - Protocol Biopsies in Renal Transplantation: Insights into Patient Management and Pathogenesis.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2007/03//
VL - 7
IS - 3
M3 - Report
SP - 512
EP - 517
PB - Wiley-Blackwell
SN - 16006135
AB - A 1-day symposium on the application of protocol biopsies in renal transplantation was held in Boston, 21 July 2006. Representatives from centers with extensive experience in the use of protocol biopsies for routine patient care and research reported results on the pathological findings and their value in patient management. The consensus was that protocol biopsies, in experienced hands, are a safe and valuable means of detecting subclinical disease that can benefit from modification of therapy. Furthermore, molecular studies reveal evidence of activity or progression not readily appreciated by histological techniques. Wider application is expected in multicenter clinical trials to predict and validate outcomes. The principal barrier to wider use of protocol biopsies is knowledge of the benefits of intervention. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - KIDNEY transplants
KW - BIOPSY
KW - MEDICAL care
KW - CLINICAL trials
KW - BOSTON (Mass.)
KW - MASSACHUSETTS
KW - Biopsy
KW - kidney
KW - protocol
KW - rejection
KW - subclinical
KW - surrogate
N1 - Accession Number: 24150396; Mengel, M. 1 Chapman, J. R. 2 Cosio, F. G. 3 Cavaillé-Coll, M. W. 4 Haller, H. 5 Halloran, P. F. 6 Kirk, A. D. 7 Mihatsch, M. J. 8 Nankivell, B. J. 2 Racusen, L. C. 9 Roberts, I. S. 10 Rush, D. N. 11 Schwarz, A. 5 Serón, D. 12 Stegall, M. D. 13 Colvin, R. B. 14; Email Address: Colvin@helix.mgh.harvard.edu; Affiliation: 1: Institute for Pathology, Hannover Medical School, Hannover, Germany 2: Center for Transplant Research and Renal Research, Westmead Hospital Sydney, Australia 3: Division of Nephrology and Hypertension, The Mayo Foundation and Clinic, Rochester, MN, USA 4: Center for Drug Evaluation and Research, Division of Special Pathogen and Transplantation Products, Food and Drug Administration, Rockville, MD, USA 5: Department of Nephrology, Hannover Medical School, Hannover, Germany 6: Alberta Transplant Applied Genomics Center, University of Alberta, Edmonton, Canada 7: Transplantation Branch, National Institute of Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA 8: Institute for Pathology, University of Basel, Switzerland 9: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA 10: Department of Pathology, Oxford-Radcliffe Hospitals, Oxford, UK 11: Department of Nephrology, University of Manitoba, Winnipeg, Canada 12: Department of Nephrology, Hospital, Universitario de Bellvitge, Barcelona, Spain 13: Department of Surgery, The Mayo Foundation and Clinic, Rochester, MN, USA 14: Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Source Info: Mar2007, Vol. 7 Issue 3, p512; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: KIDNEY transplants; Subject Term: BIOPSY; Subject Term: MEDICAL care; Subject Term: CLINICAL trials; Subject Term: BOSTON (Mass.); Subject Term: MASSACHUSETTS; Author-Supplied Keyword: Biopsy; Author-Supplied Keyword: kidney; Author-Supplied Keyword: protocol; Author-Supplied Keyword: rejection; Author-Supplied Keyword: subclinical; Author-Supplied Keyword: surrogate; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Report
L3 - 10.1111/j.1600-6143.2006.01677.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robert Shupak
T1 - Lipid Emulsion for Bupivacaine Toxicity: Too Soon to Celebrate?
JO - Anesthesiology
JF - Anesthesiology
Y1 - 2007/03//
VL - 106
IS - 3
M3 - Article
SP - 634
EP - 635
SN - 00033022
N1 - Accession Number: 24183652; Robert Shupak 1; Affiliation: 1: Sunrise Ambulatory Surgical Center and Whiteriver Hospital, Indian Health Service, Lakeside, Arizona. seaphotodoc@yahoo.com; Source Info: Mar2007, Vol. 106 Issue 3, p634; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - NANCY CLARK BURTON
AU - SERGEY A. GRINSHPUN
AU - TIINA REPONEN
T1 - Physical Collection Efficiency of Filter Materials for Bacteria and Viruses.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2007/03//
VL - 51
IS - 2
M3 - Article
SP - 143
EP - 151
SN - 00034878
AB - The purpose of this study was to determine the physical collection efficiency of commercially available filters for collecting airborne bacteria, viruses, and other particles in the 10–900 nm (nanometer) size range. Laboratory experiments with various polytetrafluoroethylene (PTFE), polycarbonate (PC) and gelatin filters in conjunction with Button™ Inhalable samplers and three-piece cassettes were undertaken. Both biological and non-biological test aerosols were used: Bacillus atrophaeus, MS2, polystyrene latex (PSL), and sodium chloride (NaCl). The B.atrophaeus endospores had an aerodynamic diameter of 900 nm, whereas MS2 virion particles ranged from 10 to 80 nm. Monodisperse 350 nm PSL particles were used as this size was believed to have the lowest filtration efficiency. NaCl solution (1% weight by volume) was used to create a polydisperse aerosol in the 10–600 nm range. The physical collection efficiency was determined by measuring particle concentrations size-selectively upstream and downstream of the filters. The PTFE and gelatin filters showed excellent collection efficiency (>93%) for all of the test particles. The PC filters showed lower collection efficiency for small particles especially <100 nm. Among the tested filters, the lowest collection efficiencies, 49 and 22%, were observed for 1 and 3-μm pore size PC filters at the particle sizes of 47 and 63 nm, respectively. The results indicate that the effect of filter material is more significant for the size range of single virions than for bacteria. The effect of filter loading was examined by exposing filters to mixtures of PSL particles, which aimed at mimicking typical indoor dust levels and size distributions. A 4-h loading did not cause significant change in the physical collection efficiency of the tested filters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FILTERS & filtration
KW - BACTERIA
KW - VIRUSES
KW - POLYTEF
N1 - Accession Number: 24394761; NANCY CLARK BURTON 1 SERGEY A. GRINSHPUN 2 TIINA REPONEN 2; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health 4676 Columbia Parkway, MS R-11, Cincinnati, OH, 45226, USA 2: Department of Environmental Health, University of Cincinnati PO Box 670056, Cincinnati, OH 45267, USA; Source Info: Mar2007, Vol. 51 Issue 2, p143; Subject Term: FILTERS & filtration; Subject Term: BACTERIA; Subject Term: VIRUSES; Subject Term: POLYTEF; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHRISTODOULIDES, NICOLAOS
AU - FLORIANO, PIERRE N.
AU - MILLER, CRAIG S.
AU - EBERSOLE, JEFFREY L.
AU - MOHANTY, SANGHAMITRA
AU - DHARSHAN, PRIYA
AU - GRIFFIN, MICHAEL
AU - LENNART, ALEXIS
AU - BALLARD, KARRI L. MICHAEL
AU - KING, CHARLES P.
AU - LANGUB, M. CHRIS
AU - KRYSCIO, RICHARD J.
AU - THOMAS, MARK V.
AU - McDEVITT, JOHN T.
T1 - Lab-on-a-Chip Methods for Point-of-Care Measurements of Salivary Biomarkers of Periodontitis.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2007/03//
VL - 1098
M3 - Article
SP - 411
EP - 428
SN - 00778923
AB - Salivary secretions contain a variety of molecules that reflect important pathophysiological activities. Quantitative changes of specific salivary biomarkers could have significance in the diagnosis and management of both oral and systemic diseases. Modern point-of-care technologies with enhanced detection capabilities are needed to implement a significant advancement in salivary diagnostics. One such promising technology is the recently described lab-on-a-chip (LOC) assay system, in which assays are performed on chemically sensitized beads populated into etched silicon wafers with embedded fluid handling and optical detection capabilities. Using this LOC system, complex assays can be performed with small sample volumes, short analysis times, and markedly reduced reagent costs. This report describes the use of LOC methodologies to assess the levels of interleukin-1β (IL-1β), C-reactive protein (CRP), and matrix metalloproteinase-8 (MMP-8) in whole saliva, and the potential use of these biomarkers for diagnosing and categorizing the severity and extent of periodontitis. This study demonstrates that the results achieved by the LOC approach are in agreement with those acquired with standard enzyme-linked immunosorbent assay (ELISA), with significant IL-1β and MMP-8 elevations in whole saliva of periodontitis patients. Furthermore, because of the superior detection capacities associated with the LOC approach, unlike those with ELISA, significant differences in CRP levels between periodontitis patients and normal subjects are observed. Finally, principal component analysis (PCA) is performed to yield an efficient method to discriminate between periodontally healthy and unhealthy patients, thus increasing the diagnostic value of these biomarkers for periodontitis when examined with the integrated LOC sensor system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALIVA
KW - SECRETION
KW - BIOCHEMICAL markers
KW - INTERLEUKIN-1
KW - PERIODONTITIS
KW - biomarkers
KW - inflammation
KW - lab-on-a-chip
KW - periodontitis
KW - salivary diagnostics
N1 - Accession Number: 24998129; CHRISTODOULIDES, NICOLAOS 1 FLORIANO, PIERRE N. 1 MILLER, CRAIG S. 2,3 EBERSOLE, JEFFREY L. 2,3 MOHANTY, SANGHAMITRA 1 DHARSHAN, PRIYA 1 GRIFFIN, MICHAEL 1 LENNART, ALEXIS 1 BALLARD, KARRI L. MICHAEL 1 KING, CHARLES P. 2 LANGUB, M. CHRIS 4,5 KRYSCIO, RICHARD J. 6 THOMAS, MARK V. 2 McDEVITT, JOHN T. 1,7,8; Email Address: mcdevitt@mail.utexas.edu; Affiliation: 1: Department of Chemistry & Biochemistry, The University of Texas at Austin, Austin, Texas, USA 2: Department of Oral Health Practice and Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky, USA 3: Department of Microbiology, Immunology & Molecular Genetics, and Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA 4: Office of Extramural Programs, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 5: Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, USA 6: Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, USA 7: Center for Nano and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas, USA 8: Texas Materials Institute, The University of Texas at Austin, Austin, Texas, USA; Source Info: 2007, Vol. 1098, p411; Subject Term: SALIVA; Subject Term: SECRETION; Subject Term: BIOCHEMICAL markers; Subject Term: INTERLEUKIN-1; Subject Term: PERIODONTITIS; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: lab-on-a-chip; Author-Supplied Keyword: periodontitis; Author-Supplied Keyword: salivary diagnostics; Number of Pages: 18p; Illustrations: 1 Color Photograph, 2 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1196/annals.1384.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Qvarnstrom, Yvonne
AU - Sullivan, James J.
AU - Bishop, Henry S.
AU - Hollingsworth, Robert
AU - da Silva, Alexandre J.
T1 - PCR-Based Detection of Angiostrongylus cantonensis in Tissue and Mucus Secretions from Molluscan Hosts.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/03//
VL - 73
IS - 5
M3 - Article
SP - 1415
EP - 1419
SN - 00992240
AB - Angiostrongylus cantonensis is a common cause of human eosinophilic meningitis. Recent outbreaks of this infection have shown that there is a need to determine the distribution of this nematode in the environment in order to control transmission. A. cantonensis is generally identified morphologically in the molluscan intermediate host by microscopic examination, which can be labor-intensive. The aim of this study was to develop a PCR-based method to detect A. cantonensis directly from molluscan tissue. A total of 34 Parmarion cf. martensi (Simroth) semislugs, 25 of which were naturally infected with A. cantonensis, were used to develop this assay. Tissue pieces (approximately 25 mg) were digested with pepsin-HCl to recover third-stage larvae for morphological identification or were used for DNA extraction. PCR primers were designed to amplify 1,134 bp from the Angiostrongylus 18S rRNA gene, and the amplicons produced were sequenced for identification at the species level. Both microscopy and the PCR-DNA sequencing analysis indicated that the same 25 semislugs were positive for A. cantonensis, showing that the two methods were equally sensitive and specific for this application. However, morphological detection requires access to living mollusks, whereas molecular analysis can also be performed with frozen tissue. The PCR-DNA sequencing method was further evaluated using tissue from Veronicella cubensis (Pfeiffer) slugs and mucus secretions from infected P. martensi. To our knowledge, this is the first use of a PCR-based method to confirm the presence of A. cantonensis in mollusks collected in the environment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLLUSKS
KW - EXOCRINE glands -- Secretions
KW - NEISSERIA meningitidis
KW - DIGESTIVE enzymes
KW - DEVELOPMENTAL biology
KW - ENVIRONMENTAL management
KW - ENVIRONMENTAL protection
KW - ENVIRONMENTAL sciences
KW - MICROBIAL ecology
N1 - Accession Number: 24500536; Qvarnstrom, Yvonne 1,2 Sullivan, James J. 1 Bishop, Henry S. 1 Hollingsworth, Robert 3 da Silva, Alexandre J. 1; Email Address: abs8@cdc.gov; Affiliation: 1: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 2: Atlanta Research and Education Foundation, Conjunction, Atlanta VA Medical Center, Decatur, Georgia 3: U.S. Pacific Basin Agricultural Research Center, U.S. Department of Agriculture, Hilo, Hawaii; Source Info: Mar2007, Vol. 73 Issue 5, p1415; Subject Term: MOLLUSKS; Subject Term: EXOCRINE glands -- Secretions; Subject Term: NEISSERIA meningitidis; Subject Term: DIGESTIVE enzymes; Subject Term: DEVELOPMENTAL biology; Subject Term: ENVIRONMENTAL management; Subject Term: ENVIRONMENTAL protection; Subject Term: ENVIRONMENTAL sciences; Subject Term: MICROBIAL ecology; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1128/AEM.01968-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reuter, G.
AU - Bíró, H.
AU - Szűcs, G.
T1 - Enteric caliciviruses in domestic pigs in Hungary.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2007/03//
VL - 152
IS - 3
M3 - Article
SP - 611
EP - 614
SN - 03048608
AB - Caliciviruses closely related to human norovirus and sapovirus were recently detected in domestic pigs, causing discussions about the animal reservoir and the potential for zoonotic transmission to humans. To detect porcine caliciviruses, 17 fecal samples collected on two swine farms in southwestern Hungary were tested by reverse transcription-polymerase chain reaction. Three (17.6%) samples were positive for caliciviruses. This study confirms the presence of caliciviruses, both porcine sapovirus (genus Sapovirus) and porcine norovirus (genus Norovirus), in domestic pigs in Hungary and provides additional information on the viral genetic diversity and relationship to viruses referred to as human caliciviruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALICIVIRUSES
KW - SWINE -- Virus diseases
KW - ANIMALS as carriers of disease
KW - COMMUNICABLE diseases -- Transmission
KW - RNA viruses
KW - HUNGARY
N1 - Accession Number: 24241193; Reuter, G. 1; Email Address: reuterg@baranya.antsz.hu Bíró, H. 2 Szűcs, G. 1; Affiliation: 1: Regional Laboratory of Virology , ÁNTSZ Baranya County Institute of State Public Health Service , Pécs Hungary 2: Aka-Hyb Kft. , Mohács Hungary; Source Info: Mar2007, Vol. 152 Issue 3, p611; Subject Term: CALICIVIRUSES; Subject Term: SWINE -- Virus diseases; Subject Term: ANIMALS as carriers of disease; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: RNA viruses; Subject Term: HUNGARY; Number of Pages: 4p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1007/s00705-006-0887-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hermalin, Albert I.
AU - Ofstedal, Mary Beth
AU - Tesfai, Rebbeca
T1 - Future Characteristics of the Elderly in Developing Countries and Their Implications for Policy.
JO - Asian Population Studies
JF - Asian Population Studies
Y1 - 2007/03//
VL - 3
IS - 1
M3 - Article
SP - 5
EP - 36
SN - 17441730
AB - Many countries in the developing world are experiencing rapid population aging, prompting concerns that this will have adverse effects on their socioeconomic advancement and on the well-being of older populations. How these forces play out in the coming years is subject to many unknowns, including world and country specific economic conditions, social changes related to family dynamics, urbanization and education, and the policies and programs adopted. What can be foreseen with more clarity is the composition of the future elderly in terms of characteristics like education, marital status, and number of children, which relate directly to their well-being on several dimensions, as well as to trends in the larger society. This paper uses the demographic technique of cohort projection to generate profiles of the elderly to 2050 on key characteristics for a set of 13 developing countries that vary by region, size, economic level, and cultural traditions. Findings show dramatic shifts in the educational attainment and family size of the elderly over the next 30-40 years. Implications of these changes for policy and program development are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Asian Population Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POPULATION aging
KW - SOCIOECONOMIC factors
KW - SOCIAL change
KW - FAMILY relations
KW - URBANIZATION
KW - EDUCATION
KW - DEVELOPING countries
KW - children ever born
KW - developing countries
KW - education
KW - elderly population
KW - marital status
KW - projections
N1 - Accession Number: 24333647; Hermalin, Albert I. 1; Email Address: alberth@isr.umich.edu Ofstedal, Mary Beth 2; Email Address: mbo@isr.umich.edu Tesfai, Rebbeca 3; Email Address: rtesfai1@jhu.edu; Affiliation: 1: Population Studies Center, University of Michigan, 426 Thompson St., Ann Arbor, MI 48106-1248, USA 2: Population Studies Center, University of Michigan 3: ASPH Fellow, Health Resources and Services Administration, Practitioner Data Banks Branch, US Department of Health and Human Services; Source Info: Mar2007, Vol. 3 Issue 1, p5; Subject Term: POPULATION aging; Subject Term: SOCIOECONOMIC factors; Subject Term: SOCIAL change; Subject Term: FAMILY relations; Subject Term: URBANIZATION; Subject Term: EDUCATION; Subject Term: DEVELOPING countries; Author-Supplied Keyword: children ever born; Author-Supplied Keyword: developing countries; Author-Supplied Keyword: education; Author-Supplied Keyword: elderly population; Author-Supplied Keyword: marital status; Author-Supplied Keyword: projections; NAICS/Industry Codes: 611710 Educational Support Services; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; Number of Pages: 32p; Illustrations: 8 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/17441730701270798
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24333647&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shin, Jinho
AU - Nam, Jusun
T1 - Validation of a computer software program for statistical analysis of accelerated stability studies on biological standards
JO - Biologicals
JF - Biologicals
Y1 - 2007/03//
VL - 35
IS - 1
M3 - Article
SP - 27
EP - 30
SN - 10451056
AB - Abstract: Long-term stability is an essential requirement for biological measurement standards and it has been evaluated by applying the Arrhenius model to the data obtained from accelerated thermostability studies. A computer program DEGTEST suited to a mainframe computer has been used for evaluating the stability of biological standards for more than a decade. This paper describes the validation of a computer program executable in a personal computer Microsoft® Windows® XP environment for the analysis of accelerated thermostability study data. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER software
KW - BIOLOGICAL control systems
KW - STABILITY (Mechanics)
KW - STATISTICS
KW - Drug stability
KW - Maximum likelihood
KW - Reference standards
KW - Software validation
N1 - Accession Number: 24148579; Shin, Jinho 1; Email Address: shinj@who.int Nam, Jusun 2; Affiliation: 1: World Health Organization, Department of Immunization, Vaccines and Biologicals, CH-1211 Geneva 27, Switzerland 2: Korea Food and Drug Administration, Center for Biologics Evaluation, Seoul 122-704, Republic of Korea; Source Info: Mar2007, Vol. 35 Issue 1, p27; Subject Term: COMPUTER software; Subject Term: BIOLOGICAL control systems; Subject Term: STABILITY (Mechanics); Subject Term: STATISTICS; Author-Supplied Keyword: Drug stability; Author-Supplied Keyword: Maximum likelihood; Author-Supplied Keyword: Reference standards; Author-Supplied Keyword: Software validation; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.biologicals.2006.01.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24148579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Shin, Jinho
AU - Wood, David
AU - Robertson, James
AU - Minor, Philip
AU - Peden, Keith
T1 - WHO informal consultation on the application of molecular methods to assure the quality, safety and efficacy of vaccines, Geneva, Switzerland, 7–8 April 2005
JO - Biologicals
JF - Biologicals
Y1 - 2007/03//
VL - 35
IS - 1
M3 - Proceeding
SP - 63
EP - 71
SN - 10451056
AB - Abstract: In April 2005, the World Health Organization convened an informal consultation on molecular methods to assure the quality, safety and efficacy of vaccines. The consultation was attended by experts from national regulatory authorities, vaccine industry and academia. Crosscutting issues on the application of molecular methods for a number of vaccines that are currently in use or under development were presented, and specific methods for further collaborative studies were discussed and identified. The main points of recommendation from meeting participants were fourfold: (i) that molecular methods should be encouraged; (ii) that collaborative studies are needed for many methods/applications; (iii) that basic science should be promoted; and (iv) that investment for training, equipment and facilities should be encouraged. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - DRUGS -- Effectiveness
KW - GENEVA (Switzerland)
KW - WORLD Health Organization
N1 - Accession Number: 24148585; Shin, Jinho 1 Wood, David; Email Address: woodd@who.int Robertson, James 2 Minor, Philip 2 Peden, Keith 3; Affiliation: 1: World Health Organization, Department of Immunizations, Vaccines and Biologicals, Avenue Appia, CH-1211 Geneva, Switzerland 2: National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, UK 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Mar2007, Vol. 35 Issue 1, p63; Subject Term: VACCINES; Subject Term: DRUGS -- Effectiveness; Subject Term: GENEVA (Switzerland); Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 9p; Document Type: Proceeding
L3 - 10.1016/j.biologicals.2005.12.005
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Cokic, Vladan P.
AU - Bhattacharya, Bhaskar
AU - Smith, Reginald D.
AU - Beleslin-Cokic, Bojana B.
AU - Noguchi, Constance T.
AU - Puri, Raj K.
AU - Schechter, Alan N.
T1 - Gene expression profiling in fetal and adult definitive erythropoiesis
JO - Blood Cells, Molecules & Diseases
JF - Blood Cells, Molecules & Diseases
Y1 - 2007/03//
VL - 38
IS - 2
M3 - Abstract
SP - 131
EP - 132
SN - 10799796
N1 - Accession Number: 23876592; Cokic, Vladan P. 1,2 Bhattacharya, Bhaskar 1,2 Smith, Reginald D. 3 Beleslin-Cokic, Bojana B. 4 Noguchi, Constance T. 5 Puri, Raj K. 6 Schechter, Alan N. 5; Affiliation: 1: Co-first authors 2: Laboratory of Experimental Hematology, Institute for Medical Research, Belgrade, Serbia and Montenegro 3: Biosciences Technologies, GE Global Research Center, Niskayuna, NY, USA 4: Institute of Endocrinology, Diabetes and Diseases of Metabolism, Belgrade, Serbia and Montenegro 5: Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, MD, USA 6: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Mar2007, Vol. 38 Issue 2, p131; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.bcmd.2006.10.031
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lazarus, Jacob E.
AU - Hegde, Anita
AU - Andrade, Anenisia C.
AU - Nilsson, Ola
AU - Baron, Jeffrey
T1 - Fibroblast growth factor expression in the postnatal growth plate
JO - BONE
JF - BONE
Y1 - 2007/03//
VL - 40
IS - 3
M3 - Article
SP - 577
EP - 586
SN - 87563282
AB - Abstract: Fibroblast growth factor (FGF) signaling is essential for endochondral bone formation. Mutations cause skeletal dysplasias including achondroplasia, the most common human skeletal dysplasia. Most previous work in this area has focused on embryonic chondrogenesis. To explore the role of FGF signaling in the postnatal growth plate, we quantitated expression of FGFs and FGF receptors (FGFRs) and examined both their spatial and temporal regulation. Toward this aim, rat proximal tibial growth plates and surrounding tissues were microdissected, and specific mRNAs were quantitated by real-time RT-PCR. To assess the FGF system without bias, we first screened for expression of all known FGFs and major FGFR isoforms. Perichondrium expressed FGFs 1, 2, 6, 7, 9, and 18 and, at lower levels, FGFs 21 and 22. Growth plate expressed FGFs 2, 7, 18, and 22. Perichondrial expression was generally greater than growth plate expression, supporting the concept that perichondrial FGFs regulate growth plate chondrogenesis. Nevertheless, FGFs synthesized by growth plate chondrocytes may be physiologically important because of their proximity to target receptors. In growth plate, we found expression of FGFRs 1, 2, and 3, primarily, but not exclusively, the c isoforms. FGFRs 1 and 3, thought to negatively regulate chondrogenesis, were expressed at greater levels and at later stages of chondrocyte differentiation, with FGFR1 upregulated in the hypertrophic zone and FGFR3 upregulated in both proliferative and hypertrophic zones. In contrast, FGFRs 2 and 4, putative positive regulators, were expressed at earlier stages of differentiation, with FGFR2 upregulated in the resting zone and FGFR4 in the resting and proliferative zones. FGFRL1, a presumed decoy receptor, was expressed in the resting zone. With increasing age and decreasing growth velocity, FGFR2 and 4 expression was downregulated in proliferative zone. Perichondrial FGF1, FGF7, FGF18, and FGF22 were upregulated. In summary, we have analyzed the expression of all known FGFs and FGFRs in the postnatal growth plate using a method that is quantitative and highly sensitive. This approach identified ligands and receptors not previously known to be expressed in growth plate and revealed a complex pattern of spatial regulation of FGFs and FGFRs in the different zones of the growth plate. We also found temporal changes in FGF and FGFR expression which may contribute to growth plate senescence and thus help determine the size of the adult skeleton. [Copyright &y& Elsevier]
AB - Copyright of BONE is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLAST growth factors
KW - GROWTH factors
KW - MUTATION (Biology)
KW - DYSPLASIA
KW - BONES -- Diseases
KW - Chondrocyte
KW - FGF
KW - FGFR
KW - fibroblast growth factor ( FGF )
KW - fibroblast growth factor receptor ( FGFR )
KW - Growth plate
KW - Senescence
N1 - Accession Number: 23868107; Lazarus, Jacob E. 1 Hegde, Anita 1 Andrade, Anenisia C. 1 Nilsson, Ola 1,2 Baron, Jeffrey 1,3; Email Address: jeffrey.baron@nih.gov; Affiliation: 1: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2: Pediatric Endocrinology Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden 3: United States Public Health Service, USA; Source Info: Mar2007, Vol. 40 Issue 3, p577; Subject Term: FIBROBLAST growth factors; Subject Term: GROWTH factors; Subject Term: MUTATION (Biology); Subject Term: DYSPLASIA; Subject Term: BONES -- Diseases; Author-Supplied Keyword: Chondrocyte; Author-Supplied Keyword: FGF; Author-Supplied Keyword: FGFR; Author-Supplied Keyword: fibroblast growth factor ( FGF ); Author-Supplied Keyword: fibroblast growth factor receptor ( FGFR ); Author-Supplied Keyword: Growth plate; Author-Supplied Keyword: Senescence; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bone.2006.10.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pezzin, Liliana E.
AU - Pollak, Robert A.
AU - Schone, Barbara S.
AD - Medical College of WI
AD - Washington U in St Louis and IZA, Bonn
AD - Agency for Healthcare Research and Quality, Rockville, MD and Georgetown U
T1 - Efficiency in Family Bargaining: Living Arrangements and Caregiving Decisions of Adult Children and Disabled Elderly Parents
JO - CESifo Economic Studies
JF - CESifo Economic Studies
Y1 - 2007/03//
VL - 53
IS - 1
SP - 69
EP - 96
SN - 1610241X
N1 - Accession Number: 1076036; Keywords: Caregiving; Disabled; Elderly; Equilibrium; Family; Nursing; Parent; Publication Type: Journal Article; Update Code: 200912
N2 - In this article, we use a two-stage bargaining model to analyze the living arrangement of a disabled elderly parent and the assistance provided to the parent by her adult children. The first stage determines the living arrangement: the parent can live in a nursing home, live alone in the community, or live with any child who has invited coresidence. The second stage determines the assistance provided by each child in the family. Working by backward induction, we first calculate the level of assistance that each child would provide to the parent in each possible living arrangement. Using these calculations, we then analyze the living arrangement that would emerge from the first stage game. A key assumption of our model is that family members cannot or will not make binding agreements at the first stage regarding transfers at the second stage. Because coresidence is likely to reduce the bargaining power of the coresident child relative to her siblings, coresidence may fail to emerge as the equilibrium living arrangement even when it is Pareto efficient. That is, the outcome of the two-stage game need not be Pareto efficient.
KW - Household Production and Intrahousehold Allocation D13
KW - Marriage; Marital Dissolution; Family Structure; Domestic Abuse J12
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://cesifo.oxfordjournals.org/archive/
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UR - http://cesifo.oxfordjournals.org/archive/
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Volpe, Donna A.
AU - Faustino, Patrick J.
AU - Ciavarella, Anthony B.
AU - Asafu-Adjaye, Ebenezer B.
AU - Ellison, Christopher D.
AU - Yu, Lawrence X.
AU - Hussain, Ajaz S.
T1 - Classification of Drug Permeability with a Caco-2 Cell Monolayer Assay.
JO - Clinical Research & Regulatory Affairs
JF - Clinical Research & Regulatory Affairs
Y1 - 2007/03//
VL - 24
IS - 1
M3 - Article
SP - 39
EP - 47
PB - Taylor & Francis Ltd
SN - 10601333
AB - In the absence of an optimized and validated protocol for the Caco-2 cell drug permeability assay, a more general approach is considered to standardize a method within a laboratory. An assay was evaluated using over 20 model drugs to assess its ability to classify drugs as high or low permeability. This cell culture method is considered to be useful as it established a relationship between experimental permeability values and extent of absorption. This represents an application of regulatory specifications to demonstrate that a cell model is able to determine the permeability class of a drug substance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Research & Regulatory Affairs is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - PERMEABILITY
KW - ABSORPTION
KW - CELL culture
KW - BIOLOGICAL assay
N1 - Accession Number: 25213959; Volpe, Donna A. 1; Email Address: donna.volpe@fda.hhs.gov Faustino, Patrick J. 1 Ciavarella, Anthony B. 1 Asafu-Adjaye, Ebenezer B. 1 Ellison, Christopher D. 1 Yu, Lawrence X. 2 Hussain, Ajaz S. 3; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration. Silver Spring, Maryland. USA 2: Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration. Rockville, Maryland. USA 3: Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Present address: Sandoz Inc.. Princeton, New Jersey. USA; Source Info: Mar2007, Vol. 24 Issue 1, p39; Subject Term: DRUGS; Subject Term: PERMEABILITY; Subject Term: ABSORPTION; Subject Term: CELL culture; Subject Term: BIOLOGICAL assay; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 9p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1080/10601330701273669
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leggat, Peter Adrian
AU - Smith, Derek Richard
T1 - Hand dermatitis among medical students from north Queensland, Australia.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 2007/03//
VL - 56
IS - 3
M3 - Article
SP - 137
EP - 139
PB - Wiley-Blackwell
SN - 01051873
AB - Although hand dermatitis (HD) is a frequent occurrence for many health professionals, little is known about the prevalence of HD among medical students, particularly in Australia. A questionnaire-based survey of HD was administered to 261 students at a medical school in tropical northern Australia during 2004 (98.9% response rate). The prevalence of HD varied by year of study, ranging from 9.7% to 20.4% ( P=0.322), with an overall prevalence of 17.4%. HD prevalence was significantly higher in those with current allergic disease ( P=0.012). Some students (13.8%) reported a reaction immediately after exposure to latex products, a finding which was associated with higher prevalence of HD ( P=0.001). HD may be more prevalent among students of a tropical Australian medical school than among their counterparts studied elsewhere. The identification of allergy as a significant correlate again stresses the importance of allergic disease and its relationship with skin conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - MEDICAL students
KW - MEDICAL schools
KW - LATEX allergy
KW - MEDICAL personnel
KW - QUEENSLAND
KW - Australia
KW - epidemiology
KW - hand dermatitis
KW - medical student
KW - risk factor
N1 - Accession Number: 23894194; Leggat, Peter Adrian 1; Email Address: peter.leggat@jcu.edu.au Smith, Derek Richard 1,2; Affiliation: 1: Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia 2: International Centre for Research Promotion and Informatics, Japan National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan; Source Info: Mar2007, Vol. 56 Issue 3, p137; Subject Term: SKIN -- Inflammation; Subject Term: MEDICAL students; Subject Term: MEDICAL schools; Subject Term: LATEX allergy; Subject Term: MEDICAL personnel; Subject Term: QUEENSLAND; Author-Supplied Keyword: Australia; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hand dermatitis; Author-Supplied Keyword: medical student; Author-Supplied Keyword: risk factor; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1111/j.1600-0536.2007.01006.x
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Webber, Keith1
AU - Spindler, Per2
T1 - Environmental Assessment of Human Pharmaceuticals in the United States of America.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/03//
Y1 - 2007/03//
VL - 41
IS - 2
CP - 2
M3 - Article
SP - 155
EP - 157
SN - 00928615
AB - This article provides an overview of a presentation of the environmental assessment process for drugs in the United States from the joint DIA/HESI/SAPS conference on Environmental Assessment of Human Medicines held in Stockholm. Sweden, May 25-23,2006. [ABSTRACT FROM AUTHOR]
KW - Environmental impact analysis
KW - Drugs
KW - Stockholm (Sweden)
KW - Sweden
KW - United States
KW - Environmental assessment
KW - Environmental protection
KW - FDA
KW - Guideline
KW - Human medicines
KW - Human pharmaceuticals
N1 - Accession Number: 24565286; Authors: Webber, Keith 1; Spindler, Per 2; Affiliations: 1: Centre for Drug Evaluation, Research, US Food and Drug Administration, USA; 2: University of Copenhagen, Denmark; Subject: Environmental impact analysis; Subject: Drugs; Subject: Stockholm (Sweden); Subject: Sweden; Subject: United States; Author-Supplied Keyword: Environmental assessment; Author-Supplied Keyword: Environmental protection; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Guideline; Author-Supplied Keyword: Human medicines; Author-Supplied Keyword: Human pharmaceuticals; Number of Pages: 3p; Illustrations: 1 Diagram; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Kelly, William N.
AU - Arellano, Felix M.
AU - Barnes, Joanne
AU - Bergman, Ulf
AU - Edwards, Ralph I.
AU - Fernandez, Alma M.
AU - Freedman, Stephen B.
AU - Goldsmith, David I.
AU - Huang, Kui A.
AU - Jones, Judith K.
AU - Mcleay, Rachel
AU - Moore, Nicholas
AU - Stather, Rosie H.
AU - Trenque, Thierry
AU - Troutman, William G.
AU - van Puijenbroek, Eugene
AU - Williams, Frank
AU - Wise, Robert P.
T1 - Guidelines for Submitting Adverse Event Reports for Publication.
JO - Drug Safety
JF - Drug Safety
Y1 - 2007/03//
VL - 30
IS - 5
M3 - Article
SP - 367
EP - 373
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Publication of case reports describing suspected adverse effects of drugs and medical products that include herbal and complementary medicines, vaccines, and other biologicals and devices is important for postmarketing surveillance. Publication lends credence to important signals raised in these adverse event reports. Unfortunately, deficiencies in vital information in published cases can often limit the value of such reports by failing to provide enough details for either (i) a differential diagnosis or provisional assessment of cause-effect association, or (ii) a reasonable pharmacological or biological explanation. Properly described, a published report of one or more adverse events can provide a useful signal of possible risks associated with the use of a drug or medical product which might warrant further exploration. A review conducted by the Task Force authors found that many major journals have minimal requirements for publishing adverse event reports, and some have none at all. Based on a literature review and our collective experience in reviewing adverse event case reports in regulatory, academic, and industry settings, we have identified information that we propose should always be considered for inclusion in a report submitted for publication. These guidelines have been endorsed by the International Society for Pharmacoepidemiology (ISPE) and the International Society of Pharmacovigilance (ISoP) and are freely available on the societies' websites. Their widespread distribution is encouraged. ISPE and ISoP urge biomedical journals to adopt these guidelines and apply them to case reports submitted for publication. They also encourage schools of medicine, pharmacy, and nursing to incorporate them into the relevant curricula that address the detection, evaluation, and reporting of suspected drug or other medical product adverse events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Side effects
KW - ALTERNATIVE medicine
KW - VACCINATION -- Complications
KW - MEDICAL equipment
KW - DIFFERENTIAL diagnosis
KW - PREVENTIVE medicine
KW - PHARMACOEPIDEMIOLOGY
KW - BIOMEDICAL organizations
KW - TASK forces
N1 - Accession Number: 25505258; Kelly, William N. 1; Email Address: wnkelly@earthlink.net Arellano, Felix M. 2,3 Barnes, Joanne 4 Bergman, Ulf 5 Edwards, Ralph I. 6 Fernandez, Alma M. 7 Freedman, Stephen B. 8 Goldsmith, David I. 9 Huang, Kui A. 10 Jones, Judith K. 11 Mcleay, Rachel 12 Moore, Nicholas 13 Stather, Rosie H. 12 Trenque, Thierry 14 Troutman, William G. 15 van Puijenbroek, Eugene 16 Williams, Frank 17 Wise, Robert P. 18; Affiliation: 1: William N. Kelly Consulting, Inc., Oldsmar, Florida, USA 2: Risk Management Resources, Bridgewater, New Jersey, USA 3: Risk Management Resources, Zaragoza, Spain 4: University of Auckland, Auckland, New Zealand 5: Karolinska Institute, Stockholm, Sweden 6: Uppsala Monitoring Centre, Uppsala, Sweden 7: TAP Pharmaceutical Products, Inc., Lake Forest, Illinois, USA 8: Hospital for Sick Children, Toronto, Ontario, Canada 9: Goldsmith Pharmacovigilance and Systems, New York, New York, USA 10: Pfizer Pharmaceuticals, New York, New York, USA 11: Degge Group, Ltd., Arlington, Virginia, USA 12: Wolters Kiuwer Health, Auckland, New Zealand 13: Université Victor Segalen, Bordeaux, France 14: Centre Hospitalier Universitaire, Reims, France 15: University of New Mexico, Albuquerque, New Mexico, USA 16: Netherlands Pharmacovigilance Centre, 's-Hertogenbosch, The Netherlands 17: United States Navy, Bethesda, Maryland, USA 18: United States Food and Drug Administration, Rockville, Maryland, USA; Source Info: 2007, Vol. 30 Issue 5, p367; Subject Term: DRUGS -- Side effects; Subject Term: ALTERNATIVE medicine; Subject Term: VACCINATION -- Complications; Subject Term: MEDICAL equipment; Subject Term: DIFFERENTIAL diagnosis; Subject Term: PREVENTIVE medicine; Subject Term: PHARMACOEPIDEMIOLOGY; Subject Term: BIOMEDICAL organizations; Subject Term: TASK forces; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tompkins, Stephen Mark
AU - Zi-Shan Zhao
AU - Chia-Yunb Lo
AU - Misplon, Julia A.
AU - Liu, Teresa
AU - Zhiping Ye
AU - Hogan, Robert J.
AU - Zhengqi Wu
AU - Benton, Kimberly A.
AU - Tumpey, Terrence M.
AU - Epstein, Suzanne L.
T1 - Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/03//
VL - 13
IS - 3
M3 - Article
SP - 426
EP - 435
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected against challenge with lethal influenza. Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and produced T-cell responses. This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Adenoviruses
KW - Extracellular matrix proteins
KW - Influenza A virus
KW - Influenza viruses
KW - Peptides
KW - Immunoglobulins
KW - T cells
N1 - Accession Number: 24274656; Tompkins, Stephen Mark 1; Email Address: tompkins@vet.uga.edu; Zi-Shan Zhao 1; Chia-Yunb Lo 1; Misplon, Julia A. 1; Liu, Teresa 1; Zhiping Ye 1; Hogan, Robert J. 2; Zhengqi Wu 1; Benton, Kimberly A. 1; Tumpey, Terrence M. 3; Epstein, Suzanne L. 1; Affiliations: 1: Food and Drug Administration, Bethesda, Maryland, USA; 2: University of Georgia, Athens, Georgia, USA; 3: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; Issue Info: Mar2007, Vol. 13 Issue 3, p426; Thesaurus Term: Vaccination; Thesaurus Term: Adenoviruses; Subject Term: Extracellular matrix proteins; Subject Term: Influenza A virus; Subject Term: Influenza viruses; Subject Term: Peptides; Subject Term: Immunoglobulins; Subject Term: T cells; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bello, Dhimiter
AU - Herrick, Christina A.
AU - Smith, Thomas J.
AU - Woskie, Susan R.
AU - Streicher, Robert P.
AU - Cullen, Mark R.
AU - Youcheng Liu
AU - Redlich, Carrie A.
T1 - Skin Exposure to Isocyanates: Reasons for Concern.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/03//
VL - 115
IS - 3
M3 - Article
SP - 328
EP - 335
PB - Superintendent of Documents
SN - 00916765
AB - OBJECTIVE: Isocyanates (di-and poly-), important chemicals used worldwide to produce polyurethane products, are a leading cause of occupational asthma. Respiratory exposures have been reduced through improved hygiene controls and the use of less-volatile isocyanates. Yet isocyanate asthma continues to occur, not uncommonly in settings with minimal inhalation exposure but opportunity for skin exposure. In this review we evaluate the potential role of skin exposure in the development of isocyanate asthma. DATA SOURCES: We reviewed the published animal and human literature on isocyanate skin-exposure methods, workplace skin exposure, skin absorption, and the role of skin exposure in isocyanate sensitization and asthma. DATA EXTRACTION: We selected relevant articles from computerized searches on Medline, U.S. Environmental Protection Agency, Occupational Safety and Health Administration, National Institute for Occupational Safety and Health, and Google databases using the keywords "isocyanate," "asthma," "skin," "sensitization," and other synonymous terms, and our own extensive collection of isocyanate publications. DATA SYNTHESIS: Isocyanate production and use continues to increase as the polyurethane industry expands. There is substantial opportunity for isocyanate skin exposure in many work settings, but such exposure is challenging to quantify and continues to be underappreciated. Isocyanate skin exposure can occur at work, even with the use of personal protective equipment, and may also occur with consumer use of certain isocyanate products. In animals, isocyanate skin exposure is an efficient route to induce sensitization, with subsequent inhalation challenge resulting in asthma-like responses. Several lines of evidence support a similar role for human isocyanate skin exposure, namely, that such exposure occurs and can contribute to the development of isocyanate asthma in certain settings, presumably by inducing systemic sensitization. CONCLUSIONS: Integrated animal and human research is needed to better understand the role of skin exposure in human isocyanate asthma and to improve diagnosis and prevention. In spite of substantial research needs, sufficient evidence already exists to justify greater emphasis on the potential risks of isocyanate skin exposure and the importance of preventing such exposures at work and during consumer use of certain isocyanate products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Poisonous gases -- Toxicology
KW - Industrial hygiene
KW - Isocyanates
KW - Skin
KW - Polyurethanes -- Environmental aspects
KW - Asthma -- Risk factors
KW - asthma
KW - dermal exposure
KW - isocyanates
KW - sensitization
KW - skin
N1 - Accession Number: 24562883; Bello, Dhimiter 1,2; Email Address: dhimiter_bello@uml.edu; Herrick, Christina A. 3; Smith, Thomas J. 1; Woskie, Susan R. 2; Streicher, Robert P. 4; Cullen, Mark R. 5; Youcheng Liu 5; Redlich, Carrie A. 5; Affiliations: 1: Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, USA; 2: Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts, USA; 3: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA; 4: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 5: Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Connecticut, USA; Issue Info: Mar2007, Vol. 115 Issue 3, p328; Thesaurus Term: RESEARCH; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Industrial hygiene; Subject Term: Isocyanates; Subject Term: Skin; Subject Term: Polyurethanes -- Environmental aspects; Subject Term: Asthma -- Risk factors; Author-Supplied Keyword: asthma; Author-Supplied Keyword: dermal exposure; Author-Supplied Keyword: isocyanates; Author-Supplied Keyword: sensitization; Author-Supplied Keyword: skin; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zheng Li
AU - Hulderman, Tracy
AU - Salmen, Rebecca
AU - Chapman, Rebecca
AU - Leonard, Stephen S.
AU - Shih-Houng Young
AU - Shvedova, Anna
AU - Luster, Michael I.
AU - Simeonova, Petia P.
T1 - Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/03//
VL - 115
IS - 3
M3 - Article
SP - 377
EP - 382
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT), are emerging as technologically important in different industries. OBJECTIVE: The unique physical characteristics and the pulmonary toxicity of SWCNTs raised concerns that respiratory exposure to these materials may be associated with cardiovascular adverse effects. METHODS: In these studies we evaluated aortic mitochondrial alterations by oxidative stress assays, including quantitative polymerase chain reaction of mitochondrial (mt) DNA and plaque formation by morphometric analysis in mice exposed to SWCNTs. RESULTS: A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice. Furthermore, we found that C57BL/6 mice, exposed to SWCNT (10 and 40 µg/mouse), developed aortic mtDNA damage at 7, 28, and 60 days after exposure. MtDNA damage was accompanied by changes in aortic mitochondrial glutathione and protein carbonyl levels. Because these modifications have been related to cardiovascular diseases, we evaluated whether repeated exposure to SWCNTs (20 µg/mouse once every other week for 8 weeks) stimulates the progression of atherosclerosis in ApoE-/- transgenic mice. Although SWCNT exposure did not modify the lipid profiles of these mice, it resulted in accelerated plaque formation in ApoE-/- mice fed an atherogenic diet. Plaque areas in the aortas, measured by the en face method, and in the brachiocephalic arteries, measured histopathologically, were significantly increased in the SWCNT-treated mice. This response was accompanied by increased mtDNA damage but not inflammation. CONCLUSIONS: Taken together, the findings are of sufficient significance to warrant further studies to evaluate the systemic effects of SWCNT under workplace or environmental exposure paradigms. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Industrial hygiene
KW - Carbon nanotubes
KW - Cardiovascular system
KW - Pulmonary toxicology
KW - Aorta -- Abnormalities
KW - Mitochondrial pathology
KW - atherosclerosis
KW - inflammatory cytokines
KW - mitochondrial DNA damage
KW - nanomaterials
KW - nanotoxicology
KW - oxidative stress
N1 - Accession Number: 24562890; Zheng Li 1; Hulderman, Tracy 1; Salmen, Rebecca 1; Chapman, Rebecca 1; Leonard, Stephen S. 2; Shih-Houng Young 2; Shvedova, Anna 2; Luster, Michael I. 1; Simeonova, Petia P. 1; Email Address: PSimeonova@cdc.gov; Affiliations: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Mar2007, Vol. 115 Issue 3, p377; Thesaurus Term: RESEARCH; Thesaurus Term: Industrial hygiene; Subject Term: Carbon nanotubes; Subject Term: Cardiovascular system; Subject Term: Pulmonary toxicology; Subject Term: Aorta -- Abnormalities; Subject Term: Mitochondrial pathology; Author-Supplied Keyword: atherosclerosis; Author-Supplied Keyword: inflammatory cytokines; Author-Supplied Keyword: mitochondrial DNA damage; Author-Supplied Keyword: nanomaterials; Author-Supplied Keyword: nanotoxicology; Author-Supplied Keyword: oxidative stress; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105983755
T1 - Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes.
AU - Li Z
AU - Hulderman T
AU - Salmen R
AU - Chapman R
AU - Leonard SS
AU - Young S
AU - Shvedova A
AU - Luster MI
AU - Simeonova PP
Y1 - 2007/03//
N1 - Accession Number: 105983755. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0330411.
KW - Aorta -- Drug Effects
KW - Arteriosclerosis -- Pathology
KW - Brachiocephalic Trunk -- Drug Effects
KW - DNA -- Drug Effects
KW - Elements
KW - Administration, Inhalation
KW - Animals
KW - Aorta -- Metabolism
KW - Aorta -- Pathology
KW - Apolipoproteins -- Deficiency
KW - Apolipoproteins
KW - Arteriosclerosis -- Metabolism
KW - Brachiocephalic Trunk -- Pathology
KW - DNA -- Metabolism
KW - DNA
KW - Gene Expression
KW - Genes
KW - Glutathione -- Metabolism
KW - Lung -- Drug Effects
KW - Lung -- Metabolism
KW - Male
KW - Mice
KW - Myocardium -- Metabolism
KW - Oxidoreductases
KW - Animal Studies
SP - 377
EP - 382
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 115
IS - 3
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - Background: Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT), are emerging as technologically important in different industries.Objective: The unique physical characteristics and the pulmonary toxicity of SWCNTs raised concerns that respiratory exposure to these materials may be associated with cardiovascular adverse effects.Methods: In these studies we evaluated aortic mitochondrial alterations by oxidative stress assays, including quantitative polymerase chain reaction of mitochondrial (mt) DNA and plaque formation by morphometric analysis in mice exposed to SWCNTs.Results: A single intrapharyngeal instillation of SWCNTs induced activation of heme oxygenase-1 (HO-1), a marker of oxidative insults, in lung, aorta, and heart tissue in HO-1 reporter transgenic mice. Furthermore, we found that C57BL/6 mice, exposed to SWCNT (10 and 40 microg/mouse), developed aortic mtDNA damage at 7, 28, and 60 days after exposure. mtDNA damage was accompanied by changes in aortic mitochondrial glutathione and protein carbonyl levels. Because these modifications have been related to cardiovascular diseases, we evaluated whether repeated exposure to SWCNTs (20 microg/mouse once every other week for 8 weeks) stimulates the progression of atherosclerosis in ApoE[-/-] transgenic mice. Although SWCNT exposure did not modify the lipid profiles of these mice, it resulted in accelerated plaque formation in ApoE[-/-] mice fed an atherogenic diet. Plaque areas in the aortas, measured by the en face method, and in the brachiocephalic arteries, measured histopathologically, were significantly increased in the SWCNT-treated mice. This response was accompanied by increased mtDNA damage but not inflammation.Conclusions: Taken together, the findings are of sufficient significance to warrant further studies to evaluate the systemic effects of SWCNT under workplace or environmental exposure paradigms.
SN - 0091-6765
AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
U2 - PMID: 17431486.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Knechtges, Paul L.
AU - Sprando, Robert L.
AU - Porter, Karen L.
AU - Brennan, Linda M.
AU - Miller, Mark F.
AU - Kumsher, David M.
AU - Dennis, William E.
AU - Brown, Charles C.
AU - Clegg, Eric D.
T1 - A NOVEL AMPHIBIAN TIER 2 TESTING PROTOCOL: A 30-WEEK EXPOSURE OF XENOPUS TROPICALIS TO THE ANTIANDROGEN FLUTAMIDE.
JO - Environmental Toxicology & Chemistry
JF - Environmental Toxicology & Chemistry
Y1 - 2007/03//
VL - 26
IS - 3
M3 - Article
SP - 555
EP - 564
SN - 07307268
AB - In 1996, the U.S. Congress mandated the development of a screening program for endocrine-disrupting chemicals (EDCs) using validated test systems. Subsequently, the Endocrine Disruptor Screening and Testing Advisory Committee recommended the development of a standardized amphibian assay for tier 2 testing of EDCs. For that reason, a tier 2 testing protocol using Xenopus (Silurana) tropicalis and a 30-week, flow-through exposure to the antiandrogen flutamide from stage 46 tadpoles through sexually mature adult frogs were developed and evaluated in this pilot study. The endpoints for this study included measurements of frog body lengths and weights, liver weights, ovary/egg mass weights, testicular and ovarian histopathology, plasma vitellogenin levels, and notes on any abnormalities observed at necropsy. Increasing exposure concentrations to flutamide caused significant increases in frogs with no recognizable gonadal tissue and increased body and liver weights in male frogs, whereas the body lengths and weights decreased significantly in female frogs. Important issues must be resolved before a tier 2 amphibian assay can be further developed and validated, including the establishment of baseline values in the controls for the parameters under study; the maintenance, measurement, and timing of exposure concentrations; and the development of additional biomolecular markers of effect. This study demonstrated the feasibility of conducting long-term EDC exposure studies using X. tropicalis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology & Chemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - XENOPUS
KW - RESEARCH
KW - ENDOCRINE glands
KW - AMPHIBIANS
KW - BIOLOGICAL assay
KW - ENVIRONMENTAL policy
KW - HORMONE antagonists
KW - ANTIANDROGENS
KW - UNITED States
KW - Amphibian
KW - Endocrine disruption
KW - Flutamide
KW - Xenopus tropicalis
KW - UNITED States. Congress
N1 - Accession Number: 42308760; Knechtges, Paul L. 1 Sprando, Robert L. 2 Porter, Karen L. 3; Email Address: karen.porter@amedd.army.mil Brennan, Linda M. 3 Miller, Mark F. 4 Kumsher, David M. 3 Dennis, William E. 1 Brown, Charles C. 5 Clegg, Eric D. 1; Affiliation: 1: U.S. Army Center for Environmental Health Research, 568 Doughten Drive, Fort Detrick, Maryland 21702-5010 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Beltsville, Maryland 20708 3: Science Applications International Corporation, U.S. Army Center for Environmental Health Research, 568 Doughten Drive, Fort Detrick, Maryland 21702-5010 4: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048, USA 5: 14017 Castaway Drive, Rockville, Maryland 20853, USA; Source Info: Mar2007, Vol. 26 Issue 3, p555; Subject Term: XENOPUS; Subject Term: RESEARCH; Subject Term: ENDOCRINE glands; Subject Term: AMPHIBIANS; Subject Term: BIOLOGICAL assay; Subject Term: ENVIRONMENTAL policy; Subject Term: HORMONE antagonists; Subject Term: ANTIANDROGENS; Subject Term: UNITED States; Author-Supplied Keyword: Amphibian; Author-Supplied Keyword: Endocrine disruption; Author-Supplied Keyword: Flutamide; Author-Supplied Keyword: Xenopus tropicalis; Company/Entity: UNITED States. Congress; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 921120 Legislative Bodies; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106139386
T1 - A new framework for evaluating potential risk of back disorders due to whole body vibration and repeated mechanical shock.
AU - Waters T
AU - Rauche C
AU - Genaidy A
AU - Rashed T
Y1 - 2007/03//
N1 - Accession Number: 106139386. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; systematic review; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Back Pain -- Etiology
KW - Health Status Indicators
KW - Motor Vehicles
KW - Occupational Diseases -- Etiology
KW - Stress, Mechanical
KW - Vibration -- Adverse Effects
KW - Descriptive Statistics
KW - Medline
KW - Professional Practice, Evidence-Based
KW - Reference Databases
KW - Relative Risk
KW - Risk Assessment
KW - Human
SP - 379
EP - 395
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 50
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A number of studies have examined the potential relationship between exposure to occupational vibration and low back pain associated with operation of vehicles. Only a handful of studies, however, have attempted to differentiate between the relative contributions of the steady state and transient mechanical shock components (the latter also being known as 'jarring and jolting', 'high acceleration event', 'multiple shocks' and 'impact') of the vibration exposure. The primary objective of this paper is to present a review of current studies that examine mechanical shock, present a case for the importance of evaluating both steady state and mechanical shock components and propose a new framework for evaluating the health effects due to occupational vibration exposure. A computerized bibliographical search of several databases was performed with special reference to the health effects of mechanical shock in relation to lower back disorders. Based on the analysis, eight experimental studies and nine epidemiological studies with relevance to exposure to 'mechanical shock' were identified. These studies suggested that rough vehicle rides are prevalent and that repeated exposure to mechanical shock may increase the risk of lower back pain. There is an urgent need for assessing the health effects of mechanical shocks in epidemiological studies. In particular, the new ISO 2631-5: International Organization for Standardization 2004 standard for shock exposure assessment should be evaluated with regard to musculoskeletal health effects.
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, ML C24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
U2 - PMID: 17536775.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Benazza-Benyahia, Amel
AU - Pesquet, Jean-Christophe
AU - Hattay, Jamel
AU - Masmoudi, Hela
T1 - Block-Based Adaptive Vector Lifting Schemes for Multichannel Image Coding.
JO - EURASIP Journal on Image & Video Processing
JF - EURASIP Journal on Image & Video Processing
Y1 - 2007///2007 Special Issue 1
VL - 2007
M3 - Article
SP - 1
EP - 10
SN - 16875176
AB - We are interested in lossless and progressive coding of multispectral images. To this respect, nonseparable vector lifting schemes are used in order to exploit simultaneously the spatial and the interchannel similarities. The involved operators are adapted to the image contents thanks to block-based procedures grounded on an entropy optimization criterion. A vector encoding technique derived from EZW allows us to further improve the efficiency of the proposed approach. Simulation tests performed on remote sensing images show that a significant gain in terms of bit rate is achieved by the resulting adaptive coding method with respect to the non-adaptive one. [ABSTRACT FROM AUTHOR]
AB - Copyright of EURASIP Journal on Image & Video Processing is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGE analysis
KW - VECTOR analysis
KW - ENTROPY (Information theory)
KW - MAXIMUM entropy method
KW - ENCODING
KW - REMOTE sensing
N1 - Accession Number: 43314538; Benazza-Benyahia, Amel 1 Pesquet, Jean-Christophe 2 Hattay, Jamel 1 Masmoudi, Hela 3,4; Affiliation: 1: Unité de Recherche en Imagerie Satellitaire et ses Applications (URISA), Ecole Supérieure des Communications (SUP'COM), Tunis 2083, Tunisia 2: Institut Gaspard Monge and CNRS-UMR 8049, Université de Marne la Vall'ee, 77454 Marne la Vallée Cédex 2, France 3: Department of Electrical and Computer Engineering, George Washington University, Washington, DC 20052, USA 4: US Food and Drug Administration, Center of Devices and Radiological Health, Division of Imaging and Applied Mathematics, Rockville, MD 20852, USA; Source Info: 2007 Special Issue 1, Vol. 2007, p1; Subject Term: IMAGE analysis; Subject Term: VECTOR analysis; Subject Term: ENTROPY (Information theory); Subject Term: MAXIMUM entropy method; Subject Term: ENCODING; Subject Term: REMOTE sensing; Number of Pages: 10p; Document Type: Article
L3 - 10.1155/2007/13421
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scheffler, Richard M.
AU - Hinshaw, Stephen P.
AU - Modrek, Sepideh
AU - Levine, Peter
T1 - The Global Market For ADHD Medications.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/03//Mar/Apr2007
VL - 26
IS - 2
M3 - Article
SP - 450
EP - 457
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Little is known about the global use and cost of medications for attention deficit hyperactivity disorder (ADHD). Global use of ADHD medications rose threefold from 1993 through 2003, whereas global spending (U.S. $2.4 billion in 2003) rose ninefold, adjusting for inflation. Per capita gross domestic product (GDP) robustly predicted use across countries, but the United States, Canada, and Australia showed significantly higher-than-predicted use. Use and spending grew in both developed and developing countries, but spending growth was concentrated in developed countries, which adopted more costly, long-acting formulations. Promoting optimal prescription and monitoring should be a priority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATTENTION-deficit hyperactivity disorder
KW - CHILDREN -- Health
KW - GROSS domestic product
KW - INFLATION (Finance)
KW - ECONOMIC development
KW - DEVELOPED countries
KW - UNITED States
N1 - Accession Number: 24357039; Scheffler, Richard M. 1,2; Email Address: rscheff@berkeley.edu Hinshaw, Stephen P. 3 Modrek, Sepideh 4 Levine, Peter 5; Affiliation: 1: Director, Nicholas C. Petris Center on Health Care Markets and Consumer Welfare, University of California, Berkeley 2: Distinguished Professor of Health Economics and Public Policy, University of California, Berkeley 3: Professor and Chair, Department of Psychology, University of California, Berkeley 4: Agency for Healthcare Research and Quality Pre-Doctoral Fellow, University of California, Berkeley 5: Physician, Department of Pediatrics, Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, California; Source Info: Mar/Apr2007, Vol. 26 Issue 2, p450; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: CHILDREN -- Health; Subject Term: GROSS domestic product; Subject Term: INFLATION (Finance); Subject Term: ECONOMIC development; Subject Term: DEVELOPED countries; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3 - 10.1377/hlthaff.26.2.450
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Han, Beth
AU - Remsburg, Robin E.
AU - McAuley, William J.
AU - Keay, Timothy J.
AU - Travis, Shirley S.
AD - US Department of Health and Human Services
AD - National Center for Health Care Statistics, Atlanta
AD - Center for Social Science Research, George Mason U
AD - U MD
AD - George Mason U
T1 - Length of Hospice Care among U.S. Adults: 1992-2000
JO - Inquiry
JF - Inquiry
Y1 - 2007///Spring
VL - 44
IS - 1
SP - 104
EP - 113
SN - 00469580
N1 - Accession Number: 0923374; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200708
N2 - This study examined length of service use among U.S. adult hospice patients based on data from the 1992-2000 National Home and Hospice Care Surveys. With the Kaplan-Meier method, we estimated length of service use of current and discharged hospice patients simultaneously. Using a multivariate Cox proportional hazards model, we examined trends in patients' service use during the 1990s. Findings show that length of service use decreased significantly among adult patients who had Medicare as their only payment source. Although overall length of service use declined significantly in 1996, 1998, and 2000 compared to 1992, it was similar between 1996 and 2000.
KW - Analysis of Health Care Markets I11
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://www.inquiryjournalonline.org/loi/inqr
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0923374&site=ehost-live&scope=site
UR - http://www.inquiryjournalonline.org/loi/inqr
DP - EBSCOhost
DB - ecn
ER -
TY - GEN
AU - Bae, Il Kwon
AU - Lee, You-Nae
AU - Jeong, Seok Hoon
AU - Lee, Kyungwon
AU - Lee, Hyukmin
AU - Kwak, Hyo-Sun
AU - Woo, Gun-Jo
T1 - High prevalence of SHV-12 and the emergence of CTX-M-12 in clinical isolates of Klebsiella pneumoniae from Korea
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2007/03//
VL - 29
IS - 3
M3 - Letter
SP - 362
EP - 364
SN - 09248579
N1 - Accession Number: 24046474; Bae, Il Kwon 1; Lee, You-Nae 1; Jeong, Seok Hoon; Email Address: kscpjsh@ns.kosinmed.or.kr; Lee, Kyungwon 2; Lee, Hyukmin 3; Kwak, Hyo-Sun 4; Woo, Gun-Jo 4; Affiliations: 1: Department of Laboratory Medicine, Kosin University College of Medicine, 602-030, 34 Amnam-Dong, Suh-Gu, Busan, South Korea; 2: Department of Laboratory Medicine, Yonsei University College of Medicine, 120-752, 134 Sin Chon-Dong Seodaemun-Gu, Seoul, South Korea; 3: Department of Laboratory Medicine, Kwandong University College of Medicine, 412-270, 697-24 Hwajeong-Dong Deogyang-Gu, Goyang, Gyeonggi-Do, South Korea; 4: Center for Food Safety Evaluation, Korea Food and Drug Administration, 122-704, 231 Jinheung-Ro, Eunpyung-Gu, Seoul, South Korea; Issue Info: Mar2007, Vol. 29 Issue 3, p362; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.ijantimicag.2006.10.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24046474&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105897984
T1 - Stability of oseltamivir in various extemporaneous liquid preparations.
AU - Ford SM
AU - Kloesel LG
AU - Grabenstein JD
AU - Ford, Stephen M Pharmd Bcps Bcop
AU - Kloesel, Lawson G Rph Bspharm Fiacp
AU - Grabenstein, John D Rph Phd
Y1 - 2007/03//2007 Mar-Apr
N1 - Accession Number: 105897984. Language: English. Entry Date: 20080425. Revision Date: 20151028. Publication Type: journal article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9706294.
KW - Oseltamivir -- Therapeutic Use
KW - Chemistry, Pharmaceutical
KW - Drug Compounding -- Methods
KW - Calibration
KW - Child
KW - Child, Preschool
KW - Chromatography, Liquid
KW - Disease Outbreaks
KW - Influenza -- Complications
KW - Influenza -- Drug Therapy
KW - Reference Values
KW - Solutions
KW - Weights and Measures
KW - Human
SP - 162
EP - 174
JO - International Journal of Pharmaceutical Compounding
JF - International Journal of Pharmaceutical Compounding
JA - INT J PHARMACEUTICAL COMPOUND
VL - 11
IS - 2
CY - Edmond, Oklahoma
PB - IJPC
AB - The purpose of this study was to determine the stability of oseltamivir, the active ingredient in Tamiflu, in contemporaneously compounded suspensions for a period of not less than 90 days. The suspension vehicles provided for the study were chosen because of ease of preparation, commercial availability, and palatability. Stability of the active ingredient was demonstrated for suspensions prepared in PCCA-Plus, PCCA Acacia, and 1% methylcellulose and was independent of storage temperature (tested temperatures were 2 deg C to 8 deg C and 25 deg C). A control sample of the commercial liquid form of Tamiflu was prepared, stored and analyzed along with the samples prepared from the contents of capsules. There was no difference in the apparent stability of the two forms of the drug preparation.
SN - 1092-4221
AD - Office of the Surgeon General, United States Army, Falls Church, Virginia
U2 - PMID: 23974623.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105897984&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Cline, Terry L.
T1 - Mental health.
JO - Issues in Science & Technology
JF - Issues in Science & Technology
Y1 - 2007///Spring2007
VL - 23
IS - 3
M3 - Editorial
SP - 18
EP - 19
PB - University of Texas at Dallas
SN - 07485492
AB - The article presents the author's views on health care for mental problems and substance use conditions in the U.S., as discussed in the article "A Healthy Mind for a Healthy Population" in the Summer 2006 issue of "Issues in Science & Technology." The author states the U.S. Substance Abuse and Mental Health Services Administration has already taken steps to transform mental health care in America and implemented a new, innovative financing approach for substance abuse treatment and recovery support services.
KW - MENTAL health services
KW - SUBSTANCE abuse -- Treatment
KW - MEDICAL care -- Finance
KW - UNITED States
KW - UNITED States. Substance Abuse & Mental Health Services Administration
N1 - Accession Number: 24522973; Cline, Terry L. 1; Affiliation: 1: Administrator, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: Spring2007, Vol. 23 Issue 3, p18; Subject Term: MENTAL health services; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: MEDICAL care -- Finance; Subject Term: UNITED States; Company/Entity: UNITED States. Substance Abuse & Mental Health Services Administration; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; Number of Pages: 2p; Document Type: Editorial; Full Text Word Count: 523
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldman, Lynn R.
AU - Osorio, Ana Maria
T1 - Introduction/Background.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/03//
VL - 12
IS - 1
M3 - Article
SP - 1
EP - 2
SN - 1059924X
AB - The article discusses various reports published within the issue including one by Sahar Sohrabian and Howard Maibach on contact dermatitis in agriculture and another by Matthew C. Keifer on the neurotoxicity of pesticides.
KW - CONTACT dermatitis
KW - PESTICIDES -- Toxicology
N1 - Accession Number: 26460242; Goldman, Lynn R. 1 Osorio, Ana Maria 2; Email Address: anamaria.osorio@fda.hhs.gov; Affiliation: 1: Professor, Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 2: Regional Medical Officer for the Pacific Region of the U.S. Food and Drug Administration; Source Info: 2007, Vol. 12 Issue 1, p1; Subject Term: CONTACT dermatitis; Subject Term: PESTICIDES -- Toxicology; Number of Pages: 2p; Document Type: Article
L3 - 10.1300/J096v12n01̱01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26460242&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Osorio, Ana Maria
T1 - Surveillance for Pesticide-Related Disease.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/03//
VL - 12
IS - 1
M3 - Article
SP - 57
EP - 66
SN - 1059924X
AB - Public health surveillance for acute pesticide intoxications is discussed. Explanation of the goals, components and functions of population-based surveillance is provided with reference to key informational sources. Both a state-based pesticide intoxication program and a nearly nationwide poison control center data base program are used to illustrate the potential uses inherent in these types of system. There is additional discussion on the investigation of disease clusters, the use of complementary exposure monitoring data and confidentiality issues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health surveillance
KW - PESTICIDES
KW - TOXICITY testing
KW - POISONING
KW - PUBLIC health
KW - AGRICULTURAL chemicals
KW - disease clusters
KW - exposure monitoring
KW - pesticide-related disease
KW - Pesticides
KW - poison control
KW - population-based surveillance
N1 - Accession Number: 26460247; Osorio, Ana Maria 1; Email Address: ananiana.osorio@fda.hhs.gov; Affiliation: 1: Regional Medical Officer for the Pacific Region of the U.S. Food and Drug Administration; Source Info: 2007, Vol. 12 Issue 1, p57; Subject Term: PUBLIC health surveillance; Subject Term: PESTICIDES; Subject Term: TOXICITY testing; Subject Term: POISONING; Subject Term: PUBLIC health; Subject Term: AGRICULTURAL chemicals; Author-Supplied Keyword: disease clusters; Author-Supplied Keyword: exposure monitoring; Author-Supplied Keyword: pesticide-related disease; Author-Supplied Keyword: Pesticides; Author-Supplied Keyword: poison control; Author-Supplied Keyword: population-based surveillance; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 2 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1300/J096v12n01̱06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26460247&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105834908
T1 - Surveillance for pesticide-related disease.
AU - Osorio AM
Y1 - 2007/03//
N1 - Accession Number: 105834908. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Occupational Diseases -- Epidemiology
KW - Occupational Diseases -- Prevention and Control
KW - Pesticides
KW - Population
KW - California
KW - Environmental Monitoring
KW - Occupational Diseases -- Etiology
KW - Pesticides -- Poisoning
KW - Poison Control Centers -- Statistics and Numerical Data
KW - Poisoning -- Epidemiology
KW - Poisoning -- Etiology
KW - Poisoning -- Prevention and Control
KW - United States
SP - 57
EP - 66
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 12
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Public health surveillance for acute pesticide intoxications is discussed. Explanation of the goals, components and functions of population-based surveillance is provided with reference to key informational sources. Both a state-based pesticide intoxication program and a nearly nationwide poison control center data base program are used to illustrate the potential uses inherent in these types of system. There is additional discussion on the investigation of disease clusters, the use of complementary exposure monitoring data and confidentiality issues.
SN - 1059-924X
AD - Regional Medical Officer for the Pacific Region of the U.S. Food and Drug Administration
U2 - PMID: 18032336.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105834908&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Whitfaker, Paul
AU - Day, James B.
AU - Curtis, Sherill K.
AU - Fry, Frederick S.
T1 - Evaluating the Use of Fatty Acid Profiles to Identify Francisella tularensis.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/03//Mar/Apr2007
VL - 90
IS - 2
M3 - Article
SP - 465
EP - 469
PB - AOAC International
SN - 10603271
AB - The article evaluates the use of fatty acid profiles to identify Francisella tularensis. The results showed that the fatty acid quantitative profiles were unique for each of the subspecies and could be used as a fingerprint for the organism. Analysus of fatty acid methyl esters from F. tularensis subspecies live vaccine strain and U112 grown on CHAB or Muller-Hinton media and using a rapid GC method can provide a sensitive procedure for identification of these organisms.
KW - FRANCISELLA tularensis
KW - FATTY acids
KW - ANTHROPOMETRY
KW - VACCINES
KW - ESTERS
N1 - Accession Number: 25055311; Whitfaker, Paul 1; Email Address: pauI.whittaker@fda.hhs.gov Day, James B. 1 Curtis, Sherill K. 1 Fry, Frederick S. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Mar/Apr2007, Vol. 90 Issue 2, p465; Subject Term: FRANCISELLA tularensis; Subject Term: FATTY acids; Subject Term: ANTHROPOMETRY; Subject Term: VACCINES; Subject Term: ESTERS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25055311&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McClure, Foster D.
AU - Lee, Jung K.
T1 - On Using an Approximate Noncentral t-Distribution in Determining a One-Side Upper Limit for Future Sample Relative Reproducibility Standard Deviations.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/03//Mar/Apr2007
VL - 90
IS - 2
M3 - Article
SP - 575
EP - 581
PB - AOAC International
SN - 10603271
AB - The article describes the use of an approximate noncentral t-distribution in determining a one-side upper limit for future sample relative reproducibility standard deviations. The accuracy of the formula with respect to the computed upper limit and probability was compared to limit values and corresponding percentile values obtained using a Monte Carlo simulation procedure.
KW - STANDARD deviations
KW - DISTRIBUTION (Probability theory)
KW - ANALYSIS of variance
KW - MONTE Carlo method
KW - PROBABILITY theory
N1 - Accession Number: 25055320; McClure, Foster D. 1; Email Address: foster.mccIure@fda.hhs.gov Lee, Jung K. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Mar/Apr2007, Vol. 90 Issue 2, p575; Subject Term: STANDARD deviations; Subject Term: DISTRIBUTION (Probability theory); Subject Term: ANALYSIS of variance; Subject Term: MONTE Carlo method; Subject Term: PROBABILITY theory; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chunliu Zhan
AU - Kaczmarek, Ronald
AU - Loyo-Berrios, Nilsa
AU - Sangl, Judith
AU - Bright, Roselie A.
T1 - Incidence and Short-Term Outcomes of Primary and Revision Hip Replacement in the United States.
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
Y1 - 2007/03//
VL - 89
IS - 3
M3 - Article
SP - 526
EP - 533
SN - 00219355
AB - Background: The purpose of this study was to use 2003 nationwide United States data to determine the incidences of primary total hip replacement, partial hip replacement, and revision hip replacement and to assess the short-term patient outcomes and factors associated with the outcomes. Methods: We screened more than eight million hospital discharge abstracts from the 2003 Healthcare Cost and Utilization Project Nationwide Inpatient Sample and approximately nine million discharge abstracts from five state inpatient databases. Patients who had undergone total, partial, or revision hip replacement were identified with use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) procedure codes. In-hospital mortality, perioperative complications, readmissions, and the association between these outcomes and certain patient and hospital variables were analyzed. Results: Approximately 200,000 total hip replacements, 100,000 partial hip replacements, and 36,000 revision hip replacements were performed in the United States in 2003. Approximately 60% of the patients were sixty-five years of age or older and at least 75% had one or more comorbid diseases. The in-hospital mortality rates associated with these three procedures were 0.33%, 3.04%, and 0.84%, respectively. The perioperative complication rates associated with the three procedures were 0.68%, 1.36%, and 1.08%, respectively, for deep vein thrombosis or pulmonary embolism; 0.28%, 1.88%, and 1.27% for decubitus ulcer; and 0.05%, 0.06%, and 0.25% for postoperative infection. The rates of readmission, for any cause, within thirty days were 4.91%, 12.15%, and 8.48%, respectively, and the rates of readmissions, within thirty days, that resulted in a surgical procedure on the affected hip were 0.79%, 0.91%, and 1.53%. The rates of readmission, for any cause, within ninety days were 8.94%, 21.14%, and 15.72%, and the rates of readmissions, within ninety days, that resulted in a surgical procedure on the affected hip were 2.15%, 1.61%, and 3.99%. Advanced age and comorbid diseases were associated with worse outcomes, while private insurance coverage and planned admissions were associated with better outcomes. No consistent association between outcomes and hospital characteristics, such as hip procedure volume, was identified. Conclusions: Total hip replacement, partial hip replacement, and revision hip replacement are associated with different rates of postoperative complications and readmissions. Advanced age, comorbidities, and nonelective admissions are associated with inferior outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bone & Joint Surgery, American Volume is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOTAL hip replacement
KW - ARTHROPLASTY
KW - MEDICAL care costs
KW - SURGICAL wound infections
KW - BEDSORES
KW - UNITED States
N1 - Accession Number: 24344853; Chunliu Zhan 1 Kaczmarek, Ronald 1 Loyo-Berrios, Nilsa 1; Email Address: nlb@cdrh.fda.gov Sangl, Judith 1; Email Address: judith.sangl@ahrq.hhs.gov Bright, Roselie A. 1; Email Address: rxb@cdrh.fda.gov; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Mar2007, Vol. 89 Issue 3, p526; Subject Term: TOTAL hip replacement; Subject Term: ARTHROPLASTY; Subject Term: MEDICAL care costs; Subject Term: SURGICAL wound infections; Subject Term: BEDSORES; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.2106/JBJS.F.00952
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24344853&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106007164
T1 - Incidence and short-term outcomes of primary and revision hip replacement in the United States.
AU - Zhan C
AU - Kaczmarek R
AU - Loyo-Berrios N
AU - Sangl J
AU - Bright RA
AU - Zhan, Chunliu
AU - Kaczmarek, Ronald
AU - Loyo-Berrios, Nilsa
AU - Sangl, Judith
AU - Bright, Roselie A
Y1 - 2007/03//
N1 - Accession Number: 106007164. Language: English. Entry Date: 20080229. Revision Date: 20160517. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0014030.
KW - Arthroplasty, Replacement, Hip
KW - Outcome Assessment
KW - Postoperative Complications -- Epidemiology
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Arthroplasty, Replacement, Hip -- Mortality
KW - Female
KW - Incidence
KW - Insurance, Health
KW - Joint Prosthesis
KW - Male
KW - Middle Age
KW - Pressure Ulcer -- Epidemiology
KW - Pulmonary Embolism -- Epidemiology
KW - Reoperation
KW - United States
KW - Venous Thrombosis -- Epidemiology
KW - Human
SP - 526
EP - 533
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
JA - J BONE JOINT SURG (AM)
VL - 89
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background: The purpose of this study was to use 2003 nationwide United States data to determine the incidences of primary total hip replacement, partial hip replacement, and revision hip replacement and to assess the short-term patient outcomes and factors associated with the outcomes.Methods: We screened more than eight million hospital discharge abstracts from the 2003 Healthcare Cost and Utilization Project Nationwide Inpatient Sample and approximately nine million discharge abstracts from five state inpatient databases. Patients who had undergone total, partial, or revision hip replacement were identified with use of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) procedure codes. In-hospital mortality, perioperative complications, readmissions, and the association between these outcomes and certain patient and hospital variables were analyzed.Results: Approximately 200,000 total hip replacements, 100,000 partial hip replacements, and 36,000 revision hip replacements were performed in the United States in 2003. Approximately 60% of the patients were sixty-five years of age or older and at least 75% had one or more comorbid diseases. The in-hospital mortality rates associated with these three procedures were 0.33%, 3.04%, and 0.84%, respectively. The perioperative complication rates associated with the three procedures were 0.68%, 1.36%, and 1.08%, respectively, for deep vein thrombosis or pulmonary embolism; 0.28%, 1.88%, and 1.27% for decubitus ulcer; and 0.05%, 0.06%, and 0.25% for postoperative infection. The rates of readmission, for any cause, within thirty days were 4.91%, 12.15%, and 8.48%, respectively, and the rates of readmissions, within thirty days, that resulted in a surgical procedure on the affected hip were 0.79%, 0.91%, and 1.53%. The rates of readmission, for any cause, within ninety days were 8.94%, 21.14%, and 15.72%, and the rates of readmissions, within ninety days, that resulted in a surgical procedure on the affected hip were 2.15%, 1.61%, and 3.99%. Advanced age and comorbid diseases were associated with worse outcomes, while private insurance coverage and planned admissions were associated with better outcomes. No consistent association between outcomes and hospital characteristics, such as hip procedure volume, was identified.Conclusions: Total hip replacement, partial hip replacement, and revision hip replacement are associated with different rates of postoperative complications and readmissions. Advanced age, comorbidities, and nonelective admissions are associated with inferior outcomes.
SN - 0021-9355
AD - Centers for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA
AD - Centers for Outcomes and Evidence, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; chunliu.zhan@ahrq.hhs.gov
U2 - PMID: 17332101.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106007164&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Meyer-Lindenberg, Andreas
AU - Straub, Richard E.
AU - Lipska, Barbara K.
AU - Verchinski, Beth A.
AU - Goldberg, Terry
AU - Callicott, Joseph H.
AU - Egan, Michael F.
AU - Huffaker, Stephen S.
AU - Mattay, Venkata S.
AU - Kolachana, Bhaskar
AU - Kleinman, Joel E.
AU - Weinberger, Daniel R.
T1 - Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2007/03//
VL - 117
IS - 3
M3 - journal article
SP - 672
EP - 682
SN - 00219738
AB - Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity. Despite extensive preclinical work, there are almost no data on DARPP-32 function in humans. Here, we identify, through resequencing in 298 chromosomes, a frequent PPP1R1B haplotype predicting mRNA expression of PPP1R1B isoforms in postmortem human brain. This haplotype was associated with enhanced performance on several cognitive tests that depend on frontostriatal function. Multimodal imaging of healthy subjects revealed an impact of the haplotype on neostriatal volume, activation, and the functional connectivity of the prefrontal cortex. The haplotype was associated with the risk for schizophrenia in 1 family-based association analysis. Our convergent results identify a prefrontal-neostriatal system affected by variation in PPP1R1B and suggest that DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOPROTEINS
KW - SCHIZOPHRENIA
KW - PSYCHOSES
KW - SCHIZOPHRENICS
KW - COGNITIVE ability
KW - DISEASES -- Risk factors
N1 - Accession Number: 25218789; Meyer-Lindenberg, Andreas 1,2,3 Straub, Richard E. 3 Lipska, Barbara K. 3 Verchinski, Beth A. 2,3 Goldberg, Terry 3 Callicott, Joseph H. 3 Egan, Michael F. 3 Huffaker, Stephen S. 3 Mattay, Venkata S. 2,3 Kolachana, Bhaskar 3 Kleinman, Joel E. 3 Weinberger, Daniel R. 3; Email Address: weinberd@mail.nih.gov; Affiliation: 1: Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health (NIMH), NIH, US Department of Health and Human Services, Bethesda, Maryland, USA 2: Neuroimaging Core Facility, National Institute for Mental Health (NIMH), NIH, US Department of Health and Human Services, Bethesda, Maryland, USA 3: Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute for Mental Health (NIMH), NIH, US Department of Health and Human Services, Bethesda, Maryland, USA; Source Info: Mar2007, Vol. 117 Issue 3, p672; Subject Term: PHOSPHOPROTEINS; Subject Term: SCHIZOPHRENIA; Subject Term: PSYCHOSES; Subject Term: SCHIZOPHRENICS; Subject Term: COGNITIVE ability; Subject Term: DISEASES -- Risk factors; Number of Pages: 11p; Illustrations: 1 Color Photograph, 1 Diagram, 3 Charts, 1 Graph; Document Type: journal article
L3 - 10.1172/JCI30413
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gelting, Richard J.
T1 - A Public Health Perspective on Onsite Wastewater Systems.
JO - Journal of Environmental Health
JF - Journal of Environmental Health
Y1 - 2007/03//
VL - 69
IS - 7
M3 - Article
SP - 62
EP - 63
PB - National Environmental Health Association
SN - 00220892
AB - The article discusses the views of the Environmental Health Services Branch of the Centers for Disease Control and Prevention towards onsite wastewater systems. The author focuses on the principal causes of outbreaks related to onsite wastewater systems: intermittent use of drinking-water and wastewater systems, as in recreational settings or large temporary gatherings (e.g., fairs); installation of onsite systems in soil and geologic environments that are unsuitable and extreme precipitation events such as those linked to hurricanes or other large storms. The author also discusses the role of health departments when dealing with wastewater pathogens and acquired immunity.
KW - Wastewater treatment
KW - Septic tanks
KW - Public health
KW - Health risk assessment
KW - Water utilities
KW - Natural disasters
KW - Pathogenic microorganisms
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 24392378; Gelting, Richard J. 1; Email Address: rug7@cdc.gov; Affiliations: 1: U.S. Public Health Service Environmental Engineer, Environmental Health Services Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS F28, Atlanta, GA 30341; Issue Info: Mar2007, Vol. 69 Issue 7, p62; Thesaurus Term: Wastewater treatment; Thesaurus Term: Septic tanks; Thesaurus Term: Public health; Thesaurus Term: Health risk assessment; Thesaurus Term: Water utilities; Thesaurus Term: Natural disasters; Thesaurus Term: Pathogenic microorganisms; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 332420 Metal Tank (Heavy Gauge) Manufacturing; NAICS/Industry Codes: 416390 Other specialty-line building supplies merchant wholesalers; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 423390 Other Construction Material Merchant Wholesalers; NAICS/Industry Codes: 562991 Septic Tank and Related Services; NAICS/Industry Codes: 562990 All other waste management services; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1104
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105697965
T1 - A public health perspective on onsite wastewater systems.
AU - Gelting RJ
Y1 - 2007/03//
N1 - Accession Number: 105697965. Language: English. Entry Date: 20081128. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. NLM UID: 0405525.
KW - Environmental Monitoring -- Methods
KW - Public Health
KW - Sewage -- Analysis
KW - United States
SP - 62
EP - 63
JO - Journal of Environmental Health
JF - Journal of Environmental Health
JA - J ENVIRON HEALTH
VL - 69
IS - 7
CY - Denver, Colorado
PB - National Environmental Health Association
SN - 0022-0892
AD - U.S. Public Health Service Environmental Engineer, Environmental Health Services Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS F28, Atlanta, GA 30341; rug7@cdc.gov
U2 - PMID: 17390904.
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DB - rzh
ER -
TY - JOUR
AU - Manangeeswaran, Mohanraj
AU - Ramalingam, Vijayanandraj V.
AU - Kumar, Karthik
AU - Mohan, Natarajan
T1 - Degradation of indulin, a kraft pine lignin, by Serratia marcescens.
JO - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
JF - Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes
Y1 - 2007/03//Mar/Apr2007
VL - 42
IS - 3
M3 - Article
SP - 321
EP - 327
PB - Taylor & Francis Ltd
SN - 03601234
AB - Serratia marcescens isolated from decaying coconut pith exhibited high lignolytic activity. Growth on indicator medium, analysis of residual indulin, and infra-red spectroscopic analysis indicated the lignolytic potential of the isolate. Ortho-Coumaric acid, ferulic acid, 2,3-dihydroxy cinnamic acid and protocatechuic acid were identified as intermediates involved in indulin degradation by S. marcescens. Qualitative confirmation and quantitative estimation of the intermediates were carried out by high performance thin layer chromatography (HPTLC). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part B -- Pesticides, Food Contaminants, & Agricultural Wastes is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Wood -- Chemistry
KW - Biomass energy
KW - Gram-negative bacteria
KW - Infrared spectroscopy
KW - Serratia marcescens
KW - Lignins
KW - Plant pigments
KW - Catechin
KW - Indulin degradation
KW - Lignin degrading bacteria
KW - Lignolytic activity
N1 - Accession Number: 24471473; Manangeeswaran, Mohanraj 1; Ramalingam, Vijayanandraj V. 2; Kumar, Karthik 2; Mohan, Natarajan 2; Affiliations: 1: Centre for advanced studies in Botany, University of Madras. Chennai. India,United States Food and Drug Administration, National Institutes of Health. Bethesda, Washington, D.C.. USA; 2: Centre for advanced studies in Botany, University of Madras. Chennai. India; Issue Info: Mar/Apr2007, Vol. 42 Issue 3, p321; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Wood -- Chemistry; Thesaurus Term: Biomass energy; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Infrared spectroscopy; Subject Term: Serratia marcescens; Subject Term: Lignins; Subject Term: Plant pigments; Subject Term: Catechin; Author-Supplied Keyword: Indulin degradation; Author-Supplied Keyword: Lignin degrading bacteria; Author-Supplied Keyword: Lignolytic activity; NAICS/Industry Codes: 221117 Biomass Electric Power Generation; NAICS/Industry Codes: 221119 Other electric power generation; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/03601230701229320
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ER -
TY - JOUR
AU - Myers, Michael J.
AU - Yancy, Haile F.
AU - Farrell, Dorothy E.
AU - Washington, Jewell D.
AU - Deaver, Christine M.
AU - Frobish, Russell A.
T1 - Assessment of Two Enzyme-Linked Immunosorbent Assay Tests Marketed for Detection of Ruminant Proteins in Finished Feed.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/03//
VL - 70
IS - 3
M3 - Article
SP - 692
EP - 699
SN - 0362028X
AB - The performance characteristics of two enzyme-linked immunosorbent assay (ELISA) test kits, ELISA Technologies' MELISA-Tek test and Tepnel BioSystems' BioKit for (Cooked) Species Identification test, designed to detect ruminant proteins in animal feed, were evaluated. The test kits were evaluated by using acceptance criteria developed by the U.S. Food and Drug Administration's Center for Veterinary Medicine Office of Research for evaluating selectivity, sensitivity, ruggedness, and specificity. The acceptance criteria for determining success used a statistical approach requiring a 90% probability of achieving the correct response within a 95% confidence interval. In practice, this measure requires the test to achieve the correct response 58 times for every 60 samples evaluated, or a 96.7% accuracy rate. A minimum detection level of 0.1% bovine meat and bone meal (BMBM) was required, consistent with the sensitivity of the analytical methods presently used by the U.S. Food and Drug Administration. Selectivity was assessed by testing 60 dairy feed samples that contained no added animal proteins; sensitivity was determined by evaluating 60 samples (per level of fortification) of this same feed that contained 0.025, 0.05, 0.1, 0.25, 0.5, 1, or 2% BMBM. The MELISA-Tek test passed the acceptance set-point criteria for selectivity assessment but failed the sensitivity assessment at all levels except at the 2% level. The MELISA-Tek test came close to passing at the 1% level, detecting true-positive findings at a rate of 93%, but failed at lower levels, in spite of the label claim of 0.5% sensitivity. The BioKit for (Cooked) Species Identification test detected only 2 of 17 samples fortified at the 2% BMBM level and failed to detect any other BMBM-fortified samples. The results of this evaluation indicate that neither test is adequate for regulatory use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bovine spongiform encephalopathy
KW - Animal industry
KW - Protein products industry
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 24731515; Myers, Michael J. 1; Email Address: michael.myers@fda.hhs.gov; Yancy, Haile F. 1; Farrell, Dorothy E. 1; Washington, Jewell D. 1; Deaver, Christine M. 1; Frobish, Russell A. 1; Affiliations: 1: Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA; Issue Info: Mar2007, Vol. 70 Issue 3, p692; Thesaurus Term: Bovine spongiform encephalopathy; Thesaurus Term: Animal industry; Subject Term: Protein products industry; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 115210 Support Activities for Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jhoo, J.-W.
AU - Ang, C. Y. W.
AU - Heinze, T. M.
AU - Deck, J.
AU - Schnackenberg, L. K.
AU - Beger, R. D.
AU - Dragull, K.
AU - Tang, C.-S.
T1 - Identification of C-glycoside Flavonoids as Potential Mutagenic Compounds in Kava.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2007/03//
VL - 72
IS - 2
M3 - Article
SP - C120
EP - C125
SN - 00221147
AB - Kava ( Piper methysticum) extract products have been implicated in a number of severe hepatotoxicity cases. However, systematic toxicological studies regarding kava consumption have not been reported. In this study, 6 major kavalactones and different solvent fractions of kava roots, leaves, and stem peelings were evaluated for their mutagenic potential. None of the kavalactones was found to be positive in the experimental concentration ranges tested by the umu test (a sensitive test for point mutations). However, among the different solvent fractions, the n-butanol fraction of kava leaves was positive. Further investigations using bioassay-directed isolation and analysis indicated that 2 C-glycoside flavonoid compounds accounted for the positive mutagenic results. Two isolated compounds were identified as 2″- O-rhamnosylvitexin and schaftoside by NMR and MS techniques. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - flavonoid
KW - kava
KW - kavalactones
KW - mutagenicity
KW - Piper methysticum
N1 - Accession Number: 24718888; Jhoo, J.-W. 1 Ang, C. Y. W. 1 Heinze, T. M. 1 Deck, J. 1 Schnackenberg, L. K. 1 Beger, R. D. 1 Dragull, K. 1 Tang, C.-S. 1; Affiliation: 1: Authors Jhoo, Ang, Heinze, Deck, Schnackenberg, and Beger are with Natl. Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079. Author Jhoo is with Kangwon Natl. Univ., Dept. of Food Science and Technology in Animal Resources, 192-1 Hyoja-2, Chunchon, Kangwon 200-701, South Korea. Authors Dragull and Tang are with Dept. of Molecular Biosciences and Bioengineering, Univ. of Hawaii at Manoa, 1955 East-West Rd., Honolulu, HI 96822. Direct inquiries to author Jhoo (E-mail: ).; Source Info: Mar2007, Vol. 72 Issue 2, pC120; Author-Supplied Keyword: flavonoid; Author-Supplied Keyword: kava; Author-Supplied Keyword: kavalactones; Author-Supplied Keyword: mutagenicity; Author-Supplied Keyword: Piper methysticum; Number of Pages: 6p; Illustrations: 4 Diagrams, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1750-3841.2007.00278.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106128171
T1 - The relationship between type and quality of social support and HIV medication adherence.
AU - Hamilton MM
AU - Razzano LA
AU - Martin NB
Y1 - 2007/03//
N1 - Accession Number: 106128171. Language: English. Entry Date: 20070803. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Instrumentation: Adult AIDS Clinical Trials Group (ACTG) Adherence Baseline & Follow up Questionnaires (AACTG-B and AACTG-F); Norbeck Social Support Questionnaire. Grant Information: Field-Initiated Research Grant Program, No. H133G010093, United States Department of Education, National Institute on Disability & Rehabilitation Research. NLM UID: 100968761.
KW - HIV Infections -- Drug Therapy
KW - Medication Compliance
KW - Support, Psychosocial
KW - Adult
KW - Analysis of Variance
KW - Chi Square Test
KW - Correlation Coefficient
KW - Descriptive Statistics
KW - Experimental Studies
KW - Family
KW - Female
KW - Funding Source
KW - Health Personnel
KW - Illinois
KW - Interviews
KW - Male
KW - Norbeck Social Support Questionnaire
KW - Patient Education
KW - Pearson's Correlation Coefficient
KW - Post Hoc Analysis
KW - Questionnaires
KW - Random Assignment
KW - Repeated Measures
KW - Seminars and Workshops
KW - Significant Other
KW - Social Networks
KW - T-Tests
KW - Human
SP - 39
EP - 63
JO - Journal of HIV/AIDS & Social Services
JF - Journal of HIV/AIDS & Social Services
JA - J HIV AIDS SOC SERV
VL - 6
IS - 1/2
PB - Taylor & Francis Ltd
AB - In the last 10 years HIV has become a disease that can be effectively managed using antiretroviral medications. However, many factors affect adherence, including demographics, income, housing, mental health issues, and access to health care, as well as types and quality of social support. This paper summarizes results regarding specific sources of social support that are part of a larger, randomized study of medication adherence among people with HIV/AIDS. Results summarize findings from 98 program participants and include information regarding support from partners, family and health care providers, as well as the impact of support from these sources on medication adherence. Among participants in this study, thosewith higher levels of social support frompartners demonstrated higher rates of medication adherence. Those who received more social support from their families, however, reported significantly lower adherence rates. These results suggest that efforts to improve medication adherence need to address the diverse types of social support networks of people diagnosed withHIV/AIDS.
SN - 1538-1501
AD - Project Manager, Center on Mental Health Services Research & Policy, Department of Psychiatry, University of Illinois at Chicago, 104 South Michigan Avenue, Suite 900, Chicago, IL 60603; Mhamilton@psych.uic.edu
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DB - rzh
ER -
TY - JOUR
AU - Adjei, M.
AU - Deck, J.
AU - Heinze, T.
AU - Freeman, J.
AU - Williams, A.
AU - Sutherland, J.
T1 - Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp.
JO - Journal of Industrial Microbiology & Biotechnology
JF - Journal of Industrial Microbiology & Biotechnology
Y1 - 2007/03//
VL - 34
IS - 3
M3 - Article
SP - 219
EP - 224
PB - Springer Science & Business Media B.V.
SN - 13675435
AB - Mycobacterium sp. 7E1B1W and seven other mycobacterial strains known to degrade hydrocarbons were investigated to determine their ability to metabolize the piperazine ring, a substructure found in many drugs. Cultures were grown at 30°C in tryptic soy broth and dosed with 3.1 mM N-phenylpiperazine hydrochloride; samples were removed at intervals and extracted with ethyl acetate. Two metabolites were purified from each of the extracts by high-performance liquid chromatography; they were identified by mass spectrometry and 1H nuclear magnetic resonance spectroscopy as N-(2-anilinoethyl)acetamide and N-acetyl- N′-phenylpiperazine. The results show that mycobacteria have the ability to acetylate piperazine rings and cleave carbon-nitrogen bonds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Industrial Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - PHENYL compounds
KW - PIPERAZINE
KW - MYCOBACTERIUM
KW - HYDROCHLORIC acid
KW - ACETAMIDE
KW - ACETYLATION
KW - Biotransformation
KW - Fluoroquinolones
KW - Mycobacterium
KW - N-phenylpiperazine
KW - Piperazine
N1 - Accession Number: 23905468; Adjei, M. 1 Deck, J. 1 Heinze, T. 2 Freeman, J. 2 Williams, A. 1 Sutherland, J. 1; Email Address: john.sutherland@fda.hhs.gov; Affiliation: 1: Division of Microbiology , National Center for Toxicological Research, US Food and Drug Administration , 3900 NCTR Road Jefferson 72079 USA 2: Division of Biochemical Toxicology , National Center for Toxicological Research, US Food and Drug Administration , 3900 NCTR Road Jefferson 72079 USA; Source Info: Mar2007, Vol. 34 Issue 3, p219; Subject Term: METABOLITES; Subject Term: PHENYL compounds; Subject Term: PIPERAZINE; Subject Term: MYCOBACTERIUM; Subject Term: HYDROCHLORIC acid; Subject Term: ACETAMIDE; Subject Term: ACETYLATION; Author-Supplied Keyword: Biotransformation; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Mycobacterium; Author-Supplied Keyword: N-phenylpiperazine; Author-Supplied Keyword: Piperazine; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1007/s10295-006-0189-x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takahashi, Yukio
AU - Harada, Noriaki
T1 - A consideration of an evaluation index for high-level low-frequency noise by taking into account the effect of human body vibration.
JO - Journal of Low Frequency Noise, Vibration & Active Control
JF - Journal of Low Frequency Noise, Vibration & Active Control
Y1 - 2007/03//
VL - 26
IS - 1
M3 - Article
SP - 15
EP - 27
SN - 02630923
AB - At high sound pressure levels, actual body vibrations (noise-induced vibrations) are induced by low-frequency noise. The purpose of this trial study was to show that considering the effects of noise-induced vibration is effective in evaluating high-level low-frequency noise. Using the A-weighted sound pressure level and the Wk-weighted vibration acceleration level of noise-induced vibration measured on the chest as independent variables, empirical evaluation indices (HLLF1, HLLF2 and HLLF3) for evaluating the unpleasantness caused by high-level low-frequency noise were estimated. The HLLF indices were found to be able to evaluate the unpleasantness caused by high-level low-frequency noise better than the A-weighted pressure level. In addition, the slopes of tentative frequency-weighting characteristics corresponding to the HLLF indices were estimated to be gentler than that of the A-weighting characteristic within 25-50 Hz, which was consistent with many previous results that indicated that noise content at lower frequencies should be given more importance when evaluating low-frequency noise Although there are several areas where the HLLF index needs to be improved before it is put in practical use, the results of this study suggest that high-level low-frequency noise could be more effectively evaluated by taking into account the effect of human body vibration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Low Frequency Noise, Vibration & Active Control is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOISE -- Physiological effect
KW - NOISE generators (Electronics)
KW - HUMAN physiology
KW - ACOUSTIC radiation pressure
KW - SOUND pressure
KW - ULTRASONICS
KW - Body surface vibration
KW - Evaluation indices
KW - High sound pressure levels
KW - Low-frequency noise
KW - Subjective unpleasantness
N1 - Accession Number: 25947226; Takahashi, Yukio 1 Harada, Noriaki 2; Email Address: takahay@h.jniosh.go.jp; Affiliation: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, Japan. 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan 2: Department of Hygiene, Yamaguchi University Graduate School of Medicine. 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan; Source Info: Mar2007, Vol. 26 Issue 1, p15; Subject Term: NOISE -- Physiological effect; Subject Term: NOISE generators (Electronics); Subject Term: HUMAN physiology; Subject Term: ACOUSTIC radiation pressure; Subject Term: SOUND pressure; Subject Term: ULTRASONICS; Author-Supplied Keyword: Body surface vibration; Author-Supplied Keyword: Evaluation indices; Author-Supplied Keyword: High sound pressure levels; Author-Supplied Keyword: Low-frequency noise; Author-Supplied Keyword: Subjective unpleasantness; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hayden, Charles S.
AU - Earnest, G. Scott
AU - Jensen, Paul A.
T1 - Development of an Empirical Model to Aid in Designing Airborne Infection Isolation Rooms.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/03//
VL - 4
IS - 3
M3 - Article
SP - 198
EP - 207
PB - Taylor & Francis Ltd
SN - 15459624
AB - Airborne infection isolation rooms (AIIRs) house patients with tuberculosis, severe acute respiratory syndrome (SARS), and many other airborne infectious diseases. Currently, faci-lity engineers and designers of heating, ventilation, and air-conditioning (HVAC) systems have few analytical tools to estimate a room's leakage area and establish an appropriate flow differential (ΔQ) in hospitals, shelters, and other facilities where communicable diseases are present. An accurate estimate of leakage area and selection of ΔQ is essential for ensuring that there is negative pressure (i.e., pressure differential [ΔP]) between an AIIR and adjoining areas. National Institute for Occupational Safety and Health (NIOSH) researchers evaluated the relationship between ΔQ and ΔP in 67 AIIRs across the United States and in simulated AIIR. Data gathered in the simulated AIIR was used to develop an empirical model describing the relationship between ΔQ, ΔP, and leakage area. Data collected in health care facilities showed that the model accurately predicted the leakage area 44 of 48 times. Statistical analysis of the model and experimental validation showed that the model effectively estimated the actual leakage area from -39% to +22% with 90% confidence. The NIOSH model is an effective, cost-cutting tool that can be used by HVAC engineers and designers to estimate leakage area and select an appropriate ΔQ in AIIRs to reduce the airborne transmission of disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Industrial hygiene
KW - SARS (Disease)
KW - Communicable diseases -- Transmission
KW - Environmental health
KW - Heating & ventilation industry
KW - Airborne infection
KW - Lung diseases
KW - airborne
KW - infection control
KW - isolation
KW - pressure difference
KW - ventilation
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 23762605; Hayden, Charles S. 1; Email Address: chayden@cdc.gov; Earnest, G. Scott 2; Jensen, Paul A. 2; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, Georgia; Issue Info: Mar2007, Vol. 4 Issue 3, p198; Thesaurus Term: Tuberculosis; Thesaurus Term: Industrial hygiene; Thesaurus Term: SARS (Disease); Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Environmental health; Thesaurus Term: Heating & ventilation industry; Subject Term: Airborne infection; Subject Term: Lung diseases; Author-Supplied Keyword: airborne; Author-Supplied Keyword: infection control; Author-Supplied Keyword: isolation; Author-Supplied Keyword: pressure difference; Author-Supplied Keyword: ventilation ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 10p; Illustrations: 1 Diagram, 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620601177370
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23762605&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Applegate, Gregory T.
AU - Wise, Tamara J.
AU - Fernback, Joseph E.
AU - Goldcamp, Michael J.
T1 - Evaluation of a Standardized Micro-Vacuum Sampling Method for Collection of Surface Dust.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/03//
VL - 4
IS - 3
M3 - Article
SP - 215
EP - 223
PB - Taylor & Francis Ltd
SN - 15459624
AB - A standardized procedure for collecting dust samples from surfaces using a micro-vacuum sampling technique was evaluated. Experiments were carried out to investigate the collection efficiency of the vacuum sampling method described in ASTM Standard D7144, “Standard Practice for Collection of Surface Dust by Micro-Vacuum Sampling for Subsequent Metals Determination.” Weighed masses (≈ 5, ≈ 10 and ≈ 25 mg) of three NIST Standard Reference Materials (SRMs) were spiked onto surfaces of various substrates. The SRMs used were: (1) Powdered Lead-Based Paint; (2) Urban Particulate Matter; and (3) Trace Elements in Indoor Dust. Twelve different substrate materials were chosen to be representative of surfaces commonly encountered in occupational and/or indoor settings: (1) wood, (2) tile, (3) linoleum, (4) vinyl, (5) industrial carpet, (6) plush carpet, (7,8) concrete block (painted and unpainted), (9) car seat material, (10) denim, (11) steel, and (12) glass. Samples of SRMs originally spiked onto these surfaces were collected using the standardized micro-vacuum sampling procedure. Gravimetric analysis of material collected within preweighed Accucapinserts (housed within the samplers) was used to measure SRM recoveries. Recoveries ranged from 21.6% (± 10.4%, 95% confidence limit [CL]) for SRM 1579 from industrial carpet to 59.2% (± 11.0%, 95% CL) for SRM 1579 from glass. For most SRM/substrate combinations, recoveries ranged from ≈ 25% to ≈ 50%; variabilities differed appreciably. In general, SRM recoveries were higher from smooth and hard surfaces and lower from rough and porous surfaces. Material captured within collection nozzles attached to the sampler inlets was also weighed. A significant fraction of SRM originally spiked onto substrate surfaces was captured within collection nozzles. Percentages of SRMs captured within collection nozzles ranged from ≈ 13% (± 4 – ± 5%, 95% CLs) for SRMs 1579 and 2583 from industrial carpet to ≈ 45% (± 7 – ± 26%, 95% CLs) for SRM 1648 from glass, tile and steel. For some substrates, loose material from the substrate itself (i.e., substrate particles and fibers) was sometimes collected along with the SRM, both within Accucaps as well as collection nozzles. Co-collection of substrate material can bias results and contribute to sampling variability. The results of this work have provided performance data on the standardized micro-vacuum sampling procedure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dust
KW - Particles
KW - Industrial hygiene
KW - Environmental health
KW - Gravimetric analysis
KW - Nozzles
KW - Vacuum cleaning
KW - Quantitative chemical analysis
KW - Floor coverings
KW - dust
KW - gravimetric analysis
KW - reference materials
KW - substrates
KW - surfaces
KW - vacuum sampling
N1 - Accession Number: 23762604; Ashley, Kevin 1; Email Address: KAshley@cdc.gov; Applegate, Gregory T.; Wise, Tamara J. 1; Fernback, Joseph E. 1; Goldcamp, Michael J. 2; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Wilmington College, Department of Chemistry, Wilmington, Ohio; Issue Info: Mar2007, Vol. 4 Issue 3, p215; Thesaurus Term: Dust; Thesaurus Term: Particles; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Subject Term: Gravimetric analysis; Subject Term: Nozzles; Subject Term: Vacuum cleaning; Subject Term: Quantitative chemical analysis; Subject Term: Floor coverings; Author-Supplied Keyword: dust; Author-Supplied Keyword: gravimetric analysis; Author-Supplied Keyword: reference materials; Author-Supplied Keyword: substrates; Author-Supplied Keyword: surfaces; Author-Supplied Keyword: vacuum sampling; NAICS/Industry Codes: 442210 Floor Covering Stores; NAICS/Industry Codes: 423220 Home Furnishing Merchant Wholesalers; NAICS/Industry Codes: 444190 Other Building Material Dealers; NAICS/Industry Codes: 414320 Floor covering merchant wholesalers; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 326198 All other plastic product manufacturing; NAICS/Industry Codes: 561720 Janitorial Services; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1080/15459620601177461
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23762604&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106169349
T1 - Development of an empirical model to aid in designing airborne infection isolation rooms.
AU - Hayden CS II
AU - Earnest GS
AU - Jensen PA
Y1 - 2007/03//
N1 - Accession Number: 106169349. Language: English. Entry Date: 20071012. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; tables/charts. Note: For CE see Suppl pages D31-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Environment, Controlled
KW - Hospital Design and Construction
KW - Infection Control -- Methods
KW - Models, Theoretical
KW - Patient Isolation -- Equipment and Supplies
KW - Patients' Rooms
KW - Education, Continuing (Credit)
KW - Air
KW - Algorithms
KW - Cost Control
KW - Infection Control -- Economics
KW - Patient Isolation -- Economics
SP - 198
EP - 207
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Airborne infection isolation rooms (AIIRs) house patients with tuberculosis, severe acute respiratory syndrome (SARS), and many other airborne infectious diseases. Currently, faci-lity engineers and designers of heating, ventilation, and air-conditioning (HVAC) systems have few analytical tools to estimate a room's leakage area and establish an appropriate flow differential (DeltaQ) in hospitals, shelters, and other facilities where communicable diseases are present. An accurate estimate of leakage area and selection of DeltaQ is essential for ensuring that there is negative pressure (i.e., pressure differential [DeltaP]) between an AIIR and adjoining areas. National Institute for Occupational Safety and Health (NIOSH) researchers evaluated the relationship between DeltaQ and DeltaP in 67 AIIRs across the United States and in simulated AIIR. Data gathered in the simulated AIIR was used to develop an empirical model describing the relationship between DeltaQ, DeltaP, and leakage area. Data collected in health care facilities showed that the model accurately predicted the leakage area 44 of 48 times. Statistical analysis of the model and experimental validation showed that the model effectively estimated the actual leakage area from -39% to +22% with 90% confidence. The NIOSH model is an effective, cost-cutting tool that can be used by HVAC engineers and designers to estimate leakage area and select an appropriate DeltaQ in AIIRs to reduce the airborne transmission of disease.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
U2 - PMID: 17237025.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106169349&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106169350
T1 - Evaluation of a standardized micro-vacuum sampling method for collection of surface dust.
AU - Ashley K
AU - Applegate GT
AU - Wise TJ
AU - Fernback JE
AU - Goldcamp MJ
Y1 - 2007/03//
N1 - Accession Number: 106169350. Language: English. Entry Date: 20071012. Revision Date: 20150711. Publication Type: Journal Article; CEU; pictorial; research; tables/charts. Note: For CE see Suppl pages D31-2. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by the U.S. Department of Energy. NLM UID: 101189458.
KW - Chemistry, Analytical -- Methods
KW - Dust -- Analysis
KW - Environmental Monitoring -- Methods
KW - Specimen Handling -- Methods
KW - Education, Continuing (Credit)
KW - Descriptive Statistics
KW - Environmental Monitoring -- Equipment and Supplies
KW - Equipment Design
KW - Funding Source
KW - Microscopy, Electron
KW - Occupational Health
KW - Sensitivity and Specificity
KW - Vacuum
KW - Weights and Measures
KW - Human
SP - 215
EP - 223
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A standardized procedure for collecting dust samples from surfaces using a micro-vacuum sampling technique was evaluated. Experiments were carried out to investigate the collection efficiency of the vacuum sampling method described in ASTM Standard D7144, 'Standard Practice for Collection of Surface Dust by Micro-Vacuum Sampling for Subsequent Metals Determination.' Weighed masses ( approximately 5, approximately 10 and approximately 25 mg) of three NIST Standard Reference Materials (SRMs) were spiked onto surfaces of various substrates. The SRMs used were: (1) Powdered Lead-Based Paint; (2) Urban Particulate Matter; and (3) Trace Elements in Indoor Dust. Twelve different substrate materials were chosen to be representative of surfaces commonly encountered in occupational and/or indoor settings: (1) wood, (2) tile, (3) linoleum, (4) vinyl, (5) industrial carpet, (6) plush carpet, (7,8) concrete block (painted and unpainted), (9) car seat material, (10) denim, (11) steel, and (12) glass. Samples of SRMs originally spiked onto these surfaces were collected using the standardized micro-vacuum sampling procedure. Gravimetric analysis of material collected within preweighed Accucapinserts (housed within the samplers) was used to measure SRM recoveries. Recoveries ranged from 21.6% (+/- 10.4%, 95% confidence limit [CL]) for SRM 1579 from industrial carpet to 59.2% (+/- 11.0%, 95% CL) for SRM 1579 from glass. For most SRM/substrate combinations, recoveries ranged from approximately 25% to approximately 50%; variabilities differed appreciably. In general, SRM recoveries were higher from smooth and hard surfaces and lower from rough and porous surfaces. Material captured within collection nozzles attached to the sampler inlets was also weighed. A significant fraction of SRM originally spiked onto substrate surfaces was captured within collection nozzles. Percentages of SRMs captured within collection nozzles ranged from approximately 13% (+/- 4 - +/- 5%, 95% CLs) for SRMs 1579 and 2583 from industrial carpet to approximately 45% (+/- 7 - +/- 26%, 95% CLs) for SRM 1648 from glass, tile and steel. For some substrates, loose material from the substrate itself (i.e., substrate particles and fibers) was sometimes collected along with the SRM, both within Accucaps as well as collection nozzles. Co-collection of substrate material can bias results and contribute to sampling variability. The results of this work have provided performance data on the standardized micro-vacuum sampling procedure.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
U2 - PMID: 17237027.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106169350&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Josyula, Arun B.
AU - Kurzius-Spencer, Margaret
AU - Littau, Sally R.
AU - Yucesoy, Berran
AU - Fleming, James
AU - Burgess, Jefferey L.
T1 - Cytokine Genotype and Phenotype Effects on Lung Function Decline in Firefighters.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/03//
VL - 49
IS - 3
M3 - Article
SP - 282
EP - 288
SN - 10762752
AB - The article presents a study on the cytokine genotype and phenotype effects on lung function decline in firefighters. The study aims to evaluate the association of cytokine genotypes and sputum concentrations on longitudinal decline in lung function in firefighters. The DNA analysis of several firefighters for functional polymorphisms of interleukin, receptor antagonist, tumor necrosis factor-alpha genes, and sputum, has shown that cytokine genotypes were associated with the rate of lung function decline, but did not alter concentrations of sputum cytokine.
KW - CYTOKINES
KW - PULMONARY function tests
KW - FIRE fighters
KW - SPUTUM
KW - LUNGS
KW - INTERLEUKINS
KW - TUMOR necrosis factor
KW - CELLULAR immunity
KW - IMMUNE system
N1 - Accession Number: 24364287; Josyula, Arun B. 1 Kurzius-Spencer, Margaret 1 Littau, Sally R. 1 Yucesoy, Berran 2 Fleming, James 3 Burgess, Jefferey L. 1; Email Address: jburgess@u.arizona.edu; Affiliation: 1: Division of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: Phoenix Fire Department, Phoenix, AZ; Source Info: Mar2007, Vol. 49 Issue 3, p282; Subject Term: CYTOKINES; Subject Term: PULMONARY function tests; Subject Term: FIRE fighters; Subject Term: SPUTUM; Subject Term: LUNGS; Subject Term: INTERLEUKINS; Subject Term: TUMOR necrosis factor; Subject Term: CELLULAR immunity; Subject Term: IMMUNE system; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1097/JOM.0b013e3180322584
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24364287&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 109848925
T1 - Patient safety in the intensive care unit: challenges and opportunities.
AU - Clancy CM
Y1 - 2007/03//2007 Mar
N1 - Accession Number: 109848925. Language: English. Entry Date: 20080321. Revision Date: 20150923. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 101233393.
KW - Intensive Care Units
KW - Time Factors
KW - Treatment Errors -- Risk Factors
KW - Diffusion of Innovation
KW - Incident Reports -- Methods
KW - Quality Improvement -- Methods
KW - Specialization
KW - Teamwork -- Methods
SP - 6
EP - 8
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 3
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Director, Agency for Healthcare Research and Quality, US Department of Health and Human Services, 540 Gaither Rd, Rockville, MD 20850; cclancy@ahrq.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109848925&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fedan, Jeffrey S.
AU - Wu, David X.-Y.
AU - Van Scott, Michael R.
T1 - Altered ion transport and responsiveness to methacholine and hyperosmolarity in air interface-cultured guinea-pig tracheal epithelium
JO - Journal of Pharmacological & Toxicological Methods
JF - Journal of Pharmacological & Toxicological Methods
Y1 - 2007/03//
VL - 55
IS - 2
M3 - Article
SP - 135
EP - 143
SN - 10568719
AB - Abstract: Introduction: : Challenge of guinea-pig tracheal epithelium with hyperosmolar solution alters ion transport and evokes the release of epithelium-derived relaxing factor (EpDRF). Cultured tracheal epithelial cells (CE) offer the potential to examine biochemical pathways related to EpDRF release, but whether the bioelectric properties and responses of fresh, adherent epithelial cells (FE) are modeled by CE has not been established. Methods: Tracheal epithelial cells grown in air-interface culture and fresh tracheal segments were mounted in Ussing chambers to determine short circuit current (I sc) and transepithelial resistance (R t) and to compare responses to transport inhibitors, methacholine and hyperosmolarity. Results: Significant differences in basal I sc and R t between FE and CE were observed (I sc, 41.3±3.5 and 8.5±0.8 μA/cm2, P <0.05; R t, 106±7 and 422±4 Ω cm2, P <0.05; respectively); basal spontaneous potential difference values were not different (4.2±0.3 and 3.4±0.3 mV, respectively). Amiloride (mucosal, 3×10−5 M), bumetanide (basolateral, 10−5 M) and ouabain (basolateral, 10−5 M) reduced I sc equally in FE and CE. In contrast, NPPB (10−5 M) in the presence of amiloride had a differential effect, decreasing I sc by 11% in FE and 71% in CE (P <0.05). Iberiotoxin (basolateral, 10−7 M) was without effect in either preparation. In FE, serosal methacholine (3×10−5 M) elicited an NPPB-insensitive monotonic increase in I sc, but in CE caused a large, transient, NPPB-inhibitable increase which was followed by an NPPB-resistant plateau. Addition of apical d-mannitol (0.3–267 mosM) to increase osmolarity decreased I sc in FE, whereas in CE d-mannitol initially increased (0.3–84.3 mosM) and then decreased (84.3–267 mosM) I sc. Discussion: Cell culture causes substantial changes in the bioelectric and pharmacological properties of respiratory epithelium. Caution should be exercised when using CE as a substitute for FE in studies of ion transport- and cell volume-dependent processes. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmacological & Toxicological Methods is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Guinea pigs
KW - Cells
KW - Epithelium
KW - Cell culture
KW - Airway
KW - Bioelectric responses
KW - Cell culture effects
KW - d-Mannitol
KW - Guinea pig
KW - Hyperosmolarity
KW - Methacholine
KW - Methods
KW - Ussing chamber
N1 - Accession Number: 24046611; Fedan, Jeffrey S. 1; Email Address: jsf2@cdc.gov; Wu, David X.-Y. 1; Van Scott, Michael R. 2; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA; 2: Department of Physiology, The Brody School of Medicine at East Carolina University, Greenville, NC 27834-4354, USA; Issue Info: Mar2007, Vol. 55 Issue 2, p135; Thesaurus Term: Guinea pigs; Subject Term: Cells; Subject Term: Epithelium; Subject Term: Cell culture; Author-Supplied Keyword: Airway; Author-Supplied Keyword: Bioelectric responses; Author-Supplied Keyword: Cell culture effects; Author-Supplied Keyword: d-Mannitol; Author-Supplied Keyword: Guinea pig; Author-Supplied Keyword: Hyperosmolarity; Author-Supplied Keyword: Methacholine; Author-Supplied Keyword: Methods; Author-Supplied Keyword: Ussing chamber; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vascn.2006.04.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24046611&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pal, Gopalendu
AU - Dutta, Ashim
AU - Mitra, Kunal
AU - Grace, Michael S.
AU - Amat, Albert
AU - Romanczyk, Tara B.
AU - Wu, Xingjia
AU - Chakrabarti, Kristi
AU - Anders, Juanita
AU - Gorman, Erik
AU - Waynant, Ronald W.
AU - Tata, Darrell B.
T1 - Effect of low intensity laser interaction with human skin fibroblast cells using fiber-optic nano-probes
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2007/03//
VL - 86
IS - 3
M3 - Article
SP - 252
EP - 261
SN - 10111344
AB - Abstract: Over the past forty years, many efforts have been devoted to study low power laser light interactions with biological systems. Some of the investigations were performed in-vitro, on bulk cell populations. Our present work was undertaken to apply specially engineered fiber-optic based nano-probes for the precise delivery of laser light on to a single cell and to observe production of low power laser light induced reactive oxygen species (ROS). A normal human skin fibroblast (NHF) cell line was utilized in this investigation and the cells were irradiated under two different schemes of exposure: (1) an entire NHF cell population within a Petri dish using a fan beam methodology, and (2) through the precise delivery of laser energy on to a single NHF cell using fiber-optic nano-probe. Photobiostimulative studies were conducted through variation of laser intensity, exposure time, and the energy dose of exposure. Laser irradiation induced enhancement in the rate of cell proliferation was observed to be dependent on laser exposure parameters and the method of laser delivery. The total energy dose (fluence) had a greater influence on the enhancement in the rate of cellular proliferation than compared to laser intensity. The enhancement in the growth rate was observed to have a finite life-time of several days after the initial laser exposure. Fluorescent life-time imaging of ROS was performed during the nano-based single cell exposure method. The kinetics of ROS generation was found to depend strongly on the laser fluence and not on the laser intensity. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology B: Biology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBROBLASTS
KW - CELL proliferation
KW - BIOLOGICAL systems
KW - ACTIVE oxygen
KW - Cell proliferation
KW - Fluorescence life-time imaging
KW - Low level light therapy (LLLT)
KW - Low power laser irradiation
KW - Nano-probes
KW - Reactive oxygen species
N1 - Accession Number: 23867447; Pal, Gopalendu 1 Dutta, Ashim 1 Mitra, Kunal 1; Email Address: kmitra@fit.edu Grace, Michael S. 2 Amat, Albert 3 Romanczyk, Tara B. 4 Wu, Xingjia 4 Chakrabarti, Kristi 3,4 Anders, Juanita 4 Gorman, Erik 3 Waynant, Ronald W. 3 Tata, Darrell B. 3; Affiliation: 1: Department of Mechanical and Aerospace Engineering, Florida Institute of Technology, 150 W University Blvd, Melbourne, FL 32901, United States 2: Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901, United States 3: Food and Drug Administration, Rockville, MD 20857, United States 4: Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States; Source Info: Mar2007, Vol. 86 Issue 3, p252; Subject Term: FIBROBLASTS; Subject Term: CELL proliferation; Subject Term: BIOLOGICAL systems; Subject Term: ACTIVE oxygen; Author-Supplied Keyword: Cell proliferation; Author-Supplied Keyword: Fluorescence life-time imaging; Author-Supplied Keyword: Low level light therapy (LLLT); Author-Supplied Keyword: Low power laser irradiation; Author-Supplied Keyword: Nano-probes; Author-Supplied Keyword: Reactive oxygen species; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jphotobiol.2006.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23867447&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106130447
T1 - Improving the system: the role of public health systems research in improving the health of all Americans.
AU - Graham G
Y1 - 2007/03//Mar/Apr2007
N1 - Accession Number: 106130447. Language: English. Entry Date: 20070810. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Health Services Research
KW - Public Health Administration -- Methods
KW - Public Health -- Methods
KW - Socioeconomic Factors
KW - Collaboration
KW - Health Services Accessibility
KW - Healthy People 2010
KW - Interinstitutional Relations
KW - Minority Groups
KW - Public Health Administration -- Standards
KW - Public Health -- Standards
KW - Quality Assurance
KW - United States
SP - 95
EP - 96
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 13
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - Office of Minority Health, US Department of Health and Human Services, Washington, District of Columbia, USA.
U2 - PMID: 17299311.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106130447&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106130450
T1 - Refining estimates of public health spending as measured in national health expenditures accounts: the United States experience.
AU - Sensenig AL
Y1 - 2007/03//Mar/Apr2007
N1 - Accession Number: 106130450. Language: English. Entry Date: 20070810. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9505213.
KW - Financing, Government
KW - Health Care Costs
KW - Public Health Administration -- Economics
KW - Public Health -- Economics
KW - Accounting
KW - Data Collection
KW - Financing, Government -- Classification
KW - Financing, Government -- Trends
KW - Government
KW - Health Care Costs -- Trends
KW - United States
SP - 103
EP - 114
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 13
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Providing for the delivery of public health services and understanding the funding mechanisms for these services are topics of great currency in the United States. In 2002, the Department of Homeland Security was created and the responsibility for providing public health services was realigned among federal agencies. State and local public health agencies are under increased financial pressures even as they shoulder more responsibilities as the vital first link in the provision of public health services. Recent events, such as hurricanes Katrina and Rita, served to highlight the need to accurately access the public health delivery system at all levels of government. The National Health Expenditure Accounts (NHEA), prepared by the National Health Statistics Group, measure expenditures on healthcare goods and services in the United States. Government public health activity constitutes an important service category in the NHEA. In the most recent set of estimates, Government Public Health Activity expenditures totaled $56.1 billion in 2004, or 3.0 percent of total US health spending. Accurately measuring expenditures for public health services in the United States presents many challenges. Among these challenges is the difficult task of defining what types of government activity constitute public health services. There is no clear-cut, universally accepted definition of government public health care services, and the definitions in the proposed International Classification for Health Accounts are difficult to apply to an individual country's unique delivery systems. Other challenges include the definitional issues associated with the boundaries of healthcare as well as the requirement that census and survey data collected from government(s) be compliant with the Classification of Functions of Government (COFOG), an internationally recognized classification system developed by the United Nations.
SN - 1078-4659
AD - National Health Statistics Group, Office of the Actuary, Centers for Medicare & Medicaid Services, US Department of Health and Human Services, USA. Arthur.Sensenig@CMS.HHS.GOV
U2 - PMID: 17299313.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106130450&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Whiting, Susan J.
AU - Green, Timothy J.
AU - Calvo, Mona S.
T1 - Vitamin D intakes in North America and Asia-Pacific countries are not sufficient to prevent vitamin D insufficiency
JO - Journal of Steroid Biochemistry & Molecular Biology
JF - Journal of Steroid Biochemistry & Molecular Biology
Y1 - 2007/03//
VL - 103
IS - 3-5
M3 - Article
SP - 626
EP - 630
SN - 09600760
AB - Abstract: Worldwide, vitamin D status is suboptimal relative to circulating levels of 25-hydroxyvitamin D (25OHD) needed to prevent a variety of chronic conditions, however, it has long been assumed that dietary intake is sufficient to meet needs when sun exposure is limited. In the USA, mean vitamin D intake from foods is close to 5μg, the Dietary Reference Intake (DRI) recommendation for persons up to 50 years; however, the amount of vitamin D needed to maintain a sufficient 25OHD level during winter is >12.5μg, and that needed for darkly pigmented, veiled, or sun protected persons is >50μg. In the USA, most vitamin D intake from foods is provided by fortification. Canada and New Zealand have fewer fortified choices, and intakes are correspondingly lower. Supplement use can increase mean intake to >12.5μg but does not always reach those who need it most. Serum 25OHD levels in New Zealand reveal much more insufficiency than expected, especially for Pacific people and Mäori; low serum 25OHD concentrations are seen throughout the Asia-Pacific region. Fortification and supplementation may be effective to achieve intakes of 12.5μg vitamin D in some of the population, but for many achieving the amount needed in the absence of skin synthesis requires intakes above the current upper level for vitamin D of 50μg. [Copyright &y& Elsevier]
AB - Copyright of Journal of Steroid Biochemistry & Molecular Biology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STEROID hormones
KW - FAT-soluble vitamins
KW - BLOOD plasma
KW - SERUM
KW - Fortification
KW - Supplementation
KW - Vitamin D intake
N1 - Accession Number: 24384722; Whiting, Susan J. 1; Email Address: susan.whiting@usask.ca Green, Timothy J. 2 Calvo, Mona S. 3; Affiliation: 1: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon SK, S7N 5C9 Canada 2: Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Mar2007, Vol. 103 Issue 3-5, p626; Subject Term: STEROID hormones; Subject Term: FAT-soluble vitamins; Subject Term: BLOOD plasma; Subject Term: SERUM; Author-Supplied Keyword: Fortification; Author-Supplied Keyword: Supplementation; Author-Supplied Keyword: Vitamin D intake; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jsbmb.2006.12.067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24384722&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maruvada, Subha
AU - Harris, Gerald R.
AU - Herman, Bruce A.
AU - King, Randy L.
T1 - Acoustic power calibration of high-intensity focused ultrasound transducers using a radiation force technique.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2007/03//
VL - 121
IS - 3
M3 - Article
SP - 1434
EP - 1439
SN - 00014966
AB - To address the challenges associated with measuring the ultrasonic power from high-intensity focused ultrasound transducers via radiation force, a technique based on pulsed measurements was developed and analyzed. Two focused ultrasound transducers were characterized in terms of an effective duty factor, which was then used to calculate the power during the pulse at high applied power levels. Two absorbing target designs were used, and both gave comparable results and displayed no damage and minimal temperature rise if placed near the transducer and away from the focus. The method yielded reproducible results up to the maximum pulse power generated of approximately 230 W, thus allowing the radiated power to be calibrated in terms of the peak-to-peak voltage applied to the transducer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC transducers
KW - RADIATION
KW - TEMPERATURE
KW - ELECTRIC potential
KW - PHYSICS
N1 - Accession Number: 24246271; Maruvada, Subha 1 Harris, Gerald R. 1 Herman, Bruce A. 1 King, Randy L. 2; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration Rockville, Maryland 20850 2: King Acoustic Technologies, LLC, Washington, DC 20007; Source Info: Mar2007, Vol. 121 Issue 3, p1434; Subject Term: ULTRASONIC transducers; Subject Term: RADIATION; Subject Term: TEMPERATURE; Subject Term: ELECTRIC potential; Subject Term: PHYSICS; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1121/1.2431332
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24246271&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Nutrition Information: Separating Facts from Fads
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2007/03//
VL - 107
IS - 3
M3 - Editorial
SP - 372
EP - 372
SN - 00028223
N1 - Accession Number: 24764668; Moritsugu, Kenneth P. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Mar2007, Vol. 107 Issue 3, p372; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2007.01.031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24764668&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106104538
T1 - From the Surgeon General. Nutrition information: separating facts from fads.
AU - Moritsugu KP
Y1 - 2007/03//
N1 - Accession Number: 106104538. Language: English. Entry Date: 20070615. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 7503061.
KW - Nutrition Education
KW - Nutrition Policy
KW - Nutritional Physiology
KW - Obesity -- Epidemiology
KW - Dietitians
KW - Health Promotion
KW - Obesity -- Diet Therapy
KW - United States
SP - 372
EP - 372
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 107
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Department of Health and Human Services.
U2 - PMID: 17324650.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106104538&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106104007
T1 - Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications.
AU - Spector W
AU - Shaffer T
AU - Potter DEB
AU - Correa-de-Araujo R
AU - Limcangco MR
Y1 - 2007/03//
N1 - Accession Number: 106104007. Language: English. Entry Date: 20070615. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 7503062.
KW - Drugs, Prescription -- Adverse Effects -- In Old Age
KW - Fractures -- Epidemiology -- In Old Age
KW - Fractures -- Risk Factors -- In Old Age
KW - Nursing Home Patients
KW - Aged
KW - Aged, 80 and Over
KW - Bivariate Statistics
KW - Cross Sectional Studies
KW - Female
KW - Geriatric Assessment
KW - Inpatients
KW - Logistic Regression
KW - Male
KW - Nurse-Patient Ratio
KW - Nursing Assistants -- Manpower
KW - Odds Ratio
KW - Prospective Studies
KW - Surveys
KW - United States
KW - Human
SP - 327
EP - 333
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
VL - 55
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVES: To determine whether resident and facility characteristics and prescription medications influence the occurrence of fractures in nursing homes (NHs). DESIGN: Panel study with 1-year follow-up. SETTING: A nationally representative sample of NHs from the Medical Expenditure Panel Survey (MEPS). PARTICIPANTS: Residents aged 65 and older who were in sample NHs on January 1, 1996. MEASUREMENTS: Health status measures were collected from facility records and abstracted using a computer-assisted personal interview instrument. Fracture and drug data were updated every 4 months to provide a full year of information. Drug data were obtained from monthly medication administration records. The occurrences of fractures were obtained from medical records. Administered medications were classified using the Department of Veterans Affairs medication classification system. Facility characteristics were based on MEPS survey data collected from NH sources. RESULTS: In 1996, 6% of residents in a NH at the beginning of the year experienced a fracture during their NH stay(s). Resident risk factors included aged 85 and older, admitted from the community, exhibited agitated behaviors, and used both wheelchair and cane or walker. Use of anticonvulsants, antidepressants, opioid analgesics, iron supplements, bisphosphonates, thiazides, and laxatives were associated with fractures. A high certified nurse aide ratio was negatively associated with fractures. CONCLUSION: The findings indicate that fractures are associated with resident and facility characteristics and prescribing practices. It reaffirms the importance of medication review with special attention on opioid analgesics, antidepressants, and anticonvulsants to reduce the risk of fractures.
SN - 0002-8614
AD - Agency for Healthcare Research and Quality, Rockville, MD;
U2 - PMID: 17341233.
DO - 10.1111/j.1532-5415.2007.01081.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106104007&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY -
AU - Sequist, Thomas D.1,2, tsequist@partners.org
AU - Cullen, Theresa3
AU - Hays, Howard3
AU - Taualii, Maile M.4
AU - Simon, Steven R.5,6
AU - Bates, David W.1
T1 - Implementation and Use of an Electronic Health Record within the Indian Health Service.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2007/03//Mar/Apr2007
Y1 - 2007/03//Mar/Apr2007
VL - 14
IS - 2
CP - 2
M3 - Article
SP - 191
EP - 197
SN - 10675027
AB - Objectives: There are limited data regarding implementing electronic health records (EHR) in underserved settings. We evaluated the implementation of an EHR within the Indian Health Service (IHS), a federally funded health system for Native Americans. Design: We surveyed 223 primary care clinicians practicing at 26 IHS health centers that implemented an EHR between 2003 and 2005. Methods: The survey instrument assessed clinician attitudes regarding EHR implementation, current utilization of individual EHR functions, and attitudes regarding the use of information technology to improve quality of care in underserved settings. We fit a multivariable logistic regression model to identify correlates of increased utilization of the EHR. Results: The overall response rate was 56%. Of responding clinicians, 66% felt that the EHR implementation process was positive. One-third (35%) believed that the EHR improved overall quality of care, with many (39%) feeling that it decreased the quality of the patient-doctor interaction. One-third of clinicians (34%) reported consistent use of electronic reminders, and self-report that EHRs improve quality was strongly associated with increased utilization of the EHR (odds ratio 3.03, 95% confidence interval 1.05-8.8). The majority (87%) of clinicians felt that information technology could potentially improve quality of care in rural and underserved settings through the use of tools such as online information sources, telemedicine programs, and electronic health records. Conclusions: Clinicians support the use of information technology to improve quality in underserved settings, but many felt that it was not currently fulfilling its potential in the IHS, potentially due to limited use of key functions within the EHR. [ABSTRACT FROM AUTHOR]
KW - Electronic records
KW - Medical records
KW - Medical informatics
KW - Electronic information resources
KW - Native Americans -- Medical care
KW - Telecommunication in medicine
KW - United States. Indian Health Service
KW - United States
N1 - Accession Number: 24503286; Authors: Sequist, Thomas D. 1,2 Email Address: tsequist@partners.org; Cullen, Theresa 3; Hays, Howard 3; Taualii, Maile M. 4; Simon, Steven R. 5,6; Bates, David W. 1; Affiliations: 1: Division of General Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA; 2: Department of Health Care Policy, Harvard Medical School, Boston, MA; 3: Indian Health Service Office of Information Technology, Phoenix, AZ; 4: Seattle Indian Health Board, Seattle, WA; 5: Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA; 6: Harvard Pilgrim Health Care, Boston, MA; Subject: Electronic records; Subject: Medical records; Subject: Medical informatics; Subject: United States. Indian Health Service; Subject: Native Americans -- Medical care; Subject: Telecommunication in medicine; Subject: Electronic information resources; Subject: United States; Number of Pages: 7p; Illustrations: 4 Charts, 1 Graph; Record Type: Article
L3 - 10.1197/jamia.M2234
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=24503286&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Chen, James J.
AU - Moon, Hojin
AU - Baek, Songjoon
AD - National Center for Toxicological Research, US Food and Drug Administration
AD - National Center for Toxicological Research, US Food and Drug Administration
AD - National Center for Toxicological Research, US Food and Drug Administration
T1 - Tree-Based Ensemble Classifiers for High-Dimensional Data
JO - Journal of the Chinese Statistical Association
JF - Journal of the Chinese Statistical Association
Y1 - 2007/03//
VL - 45
IS - 1
SP - 1
EP - 17
SN - 05296528
N1 - Accession Number: 0950123; Publication Type: Journal Article; Update Code: 200801
N2 - Building a classification model from thousands of available predictor variables with a relatively small sample size presents challenges for most traditional classification algorithms. When the number of samples is much smaller than the number of predictors, there can be a multiplicity of good classification models. An ensemble classifier combines multiple single classifiers to improve classification accuracy. This paper overviews tree-based classifiers and compares the performance of the three ensemble classifiers: random forest (RF), classification by ensembles from random partitions (CERP), and adaptive boosting (AdaBoost), and three single tree algorithms are also evaluated, classification tree (CTree), classification rule with unbiased interaction selection and estimation (CRUISE), and quick, unbiased and efficient statistical tree (QUEST). The six tree-based classifiers are applied to five high-dimensional datasets. In all datasets, the three ensemble classifiers show much higher classification accuracies than the three single tree algorithms, with the exception of the AdaBoost ensemble classifier in one dataset. RF and CERP are comparable in terms of accuracy. The RF and CERP bagging classifiers show higher accuracies than the AdaBoost boosting classifier. For the three tree classifiers, QUEST generally shows higher accuracy than CTree and CRUISE.
KW - Related Disciplines Y80
L3 - http://jcsa35.ncu.edu.tw/OutWeb/L_CT/Journal/Journal_Page2_List.asp?Flag=1#
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UR - http://jcsa35.ncu.edu.tw/OutWeb/L_CT/Journal/Journal_Page2_List.asp?Flag=1#
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 106295357
T1 - Health, spending and the effort to improve quality in OECD countries: a review of the data.
AU - Kelley E
Y1 - 2007/03//
N1 - Accession Number: 106295357. Language: English. Entry Date: 20070601. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Europe; Health Promotion/Education; Peer Reviewed; Public Health; UK & Ireland. NLM UID: 101499616.
KW - Health Care Delivery
KW - Health Status Indicators
KW - Public Health
KW - Quality of Health Care
KW - World Health
KW - Aged
KW - Alcohol Drinking
KW - Australia
KW - Canada
KW - Clinical Indicators
KW - Europe
KW - Female
KW - Health Resource Allocation
KW - Japan
KW - Korea
KW - Life Expectancy
KW - Male
KW - Mexico
KW - Myocardial Infarction -- Mortality
KW - Turkey
KW - United States
SP - 64
EP - 71
JO - Journal of the Royal Society for the Promotion of Health
JF - Journal of the Royal Society for the Promotion of Health
JA - J R SOC PROMOT HEALTH
VL - 127
IS - 2
PB - Sage Publications, Ltd.
AB - The performance of health systems is of concern to both policy-makers and academics and a large body of recent literature has advanced the debate significantly on methods and results of health system performance assessments. In this article, I attempt to summarize what is known about a range of areas of health system performance, specifically in the areas of spending and outcomes, using data from the Organization for Economic Cooperation and Development (OECD) in the areas of health, spending, risk factors and quality of care. In so doing, we use new data from the OECD's Health Care Quality Indicators (HCQI) to examine a factor that is frequently cited at the national level but rarely compared at the international level, namely the quality of the healthcare provided. In keeping with other assessments of trends in health, we show that health has improved dramatically since the 1970s in all of the countries of the OECD. Likewise, all of the OECD countries are spending many times more on health per person than in 1970. However, the gains in health as well as the spending levels vary tremendously across countries. Quality of care is relatively high in some areas such as vaccination rates. In other areas such as breast cancer survival, the HCQI data show that most countries are making progress somewhat universally, but that all countries still have progress to be made. Finally, in other areas, such as inpatient care for acute myocardial infarction (AMI), there is wide variation in quality. Future work will need to be undertaken in order to examine possible best practices at the policy and operational level of health care delivery, their impact on spending and, most importantly, on health outcomes.
SN - 1466-4240
AD - Director, National Healthcare Quality Report, Agency for Healthcare Research and Quality, edward.kelley@AHRQ.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mirfazaelian, Ahmad
AU - Kyu-Bong Kim
AU - Sookwang Lee
AU - Kim, Hyo J.
AU - Bruckner, James V.
AU - Fisher, Jeffrey W.
T1 - Organ Growth Functions in Maturing Male Sprague-Dawley Rats.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/03//
VL - 70
IS - 5
M3 - Article
SP - 429
EP - 438
SN - 15287394
AB - Growth equations can be used in physiologically based pharmacokinetic (PBPK) modeling to provide physiological parameters (e.g., body weight, tissue/organ volumes) for maturing rodents. No diligent systematic exercise was found in the literature dealing with growth equations for developing rats' tissues. A generalized Michaelis-Menten (GMM) model, originally developed to fit body weight vs. age data, was chosen to estimate different physiological compartment sizes. The GMM model has the functional form: Wt = (Wto.Kγ + Wtmax.Ageγ)/(Kγ + Ageγ) where Wt is organ/tissue weight at a specified age, Wto and Wtmax are weight at birth and maximal growth respectively, and K and γ are constants. Weights of freshly collected organs (liver, spleen, kidneys, heart, lungs, brain, gastrointestinal tract and adipose tissue), measured in male Sprague-Dawley rats of different ages (1-280 d) in our laboratory, were used to evaluate this model's performance. The GMM model was fitted to the organ weights, and the resulting parameters were statistically significant for all organs and tissues. Organ weights were highly correlated with their respective ages. GMM-derived organ growth and percent body weight (%BW) fractions of different tissues were plotted against animal age and compared with experimental values. The GMM-based organ growth and %BW fraction profiles were in general agreement with our empirical data as well as previous studies. The GMM model gave adequately precise weight predictions at all ages for all the tissues/organs examined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TISSUES
KW - ORGANS (Anatomy)
KW - RATS as laboratory animals
KW - PHARMACOKINETICS
KW - BODY weight
KW - BODY size
KW - BIRTH weight
KW - EMPIRICAL research
KW - RODENTS
N1 - Accession Number: 24515510; Mirfazaelian, Ahmad 1,2 Kyu-Bong Kim 3,4 Sookwang Lee 4 Kim, Hyo J. 4 Bruckner, James V. 4 Fisher, Jeffrey W. 2; Email Address: jwfisher@uga.edu; Affiliation: 1: Department of Pharmaceutics, School of Pharmacy, University of Tehran, Tehran, Iran. 2: Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA. 3: Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea. 4: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia, USA.; Source Info: Mar2007, Vol. 70 Issue 5, p429; Subject Term: TISSUES; Subject Term: ORGANS (Anatomy); Subject Term: RATS as laboratory animals; Subject Term: PHARMACOKINETICS; Subject Term: BODY weight; Subject Term: BODY size; Subject Term: BIRTH weight; Subject Term: EMPIRICAL research; Subject Term: RODENTS; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15287390600755265
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lambert, Amy J.
AU - Kosoy, Olga
AU - Velez, Jason O.
AU - Russell, Brandy J.
AU - Lanciotti, Robert S.
T1 - Detection of Colorado Tick Fever viral RNA in acute human serum samples by a quantitative real-time RT-PCR assay
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2007/03//
VL - 140
IS - 1/2
M3 - Article
SP - 43
EP - 48
SN - 01660934
AB - Abstract: A quantitative real-time RT-PCR assay for the detection of Colorado Tick Fever (CTF) viral RNA in human clinical samples is presented. The sensitivity of this assay has been shown to be greater than that of the isolation of virus in Vero cells by standard plaque assay in a direct comparison. The specificity of the CTF quantitative real-time RT-PCR assay was determined by the exclusive detection of CTF viral RNAs when applied to a diverse panel of CTF viral isolates and reference strain agents known to circulate in areas of CTF virus transmission. Lastly, the quantitative real-time RT-PCR assay demonstrated exceptional sensitivity for the detection of CTF viral RNA in acute human serum. The quantitative real-time RT-PCR assay is efficient, sensitive and specific and as such is useful for the detection of CTF viral RNA in the diagnostic or research laboratory. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases
KW - TICK-borne diseases
KW - COMMUNICABLE diseases
KW - CELL separation
KW - CTF virus RT-PCR
KW - Real-time assay
N1 - Accession Number: 23864734; Lambert, Amy J.; Email Address: ahk7@cdc.gov Kosoy, Olga 1 Velez, Jason O. 1 Russell, Brandy J. 1 Lanciotti, Robert S. 1; Affiliation: 1: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Rampert Road, Fort Collins, CO 80521, United States; Source Info: Mar2007, Vol. 140 Issue 1/2, p43; Subject Term: VIRUS diseases; Subject Term: TICK-borne diseases; Subject Term: COMMUNICABLE diseases; Subject Term: CELL separation; Author-Supplied Keyword: CTF virus RT-PCR; Author-Supplied Keyword: Real-time assay; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jviromet.2006.10.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23864734&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeong, J.Y.
AU - Lee, E.S.
AU - Choi, J.H.
AU - Lee, J.Y.
AU - Kim, J.M.
AU - Min, S.G.
AU - Chae, Y.C.
AU - Kim, C.J.
T1 - Variability in temperature distribution and cooking properties of ground pork patties containing different fat level and with/without salt cooked by microwave energy
JO - Meat Science
JF - Meat Science
Y1 - 2007/03//
VL - 75
IS - 3
M3 - Article
SP - 415
EP - 422
SN - 03091740
AB - Abstract: This study was carried out to evaluate the cooking effects of fat level (10% and 20%) with and without NaCl (1.5%) on the microwave cooking pattern and properties of ground pork patties. Each patty was cooked from a thawed state to 76.7°C in a microwave oven with full power (900W). Cooking rate in patties produced without salt was not affected by fat level, but the addition of salt in pork patties decreased cooking rate, regardless of fat levels. The temperatures at the edges of the patties increased faster than those at the center or the mid-way positions. In the patties with NaCl, the temperature of the center position was higher than that of the mid-way position. Patties containing salt within the same fat level had higher moisture content and lower fat content than those without salt, although no significant differences in compositional properties were observed between the center, midway, or edge positions. Total cooking loss, drip loss, and reduction in diameter and thickness were higher in patties with 20% fat compared to those with 10% fat, but the addition of salt resulted in reduction, regardless of fat level. Also, the addition of salt increased the redness and reduced yellowness of the cooked products. [Copyright &y& Elsevier]
AB - Copyright of Meat Science is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PORK
KW - FOOD -- Fat content
KW - MEAT
KW - FOOD science
KW - Fat level
KW - Ground pork patties
KW - Microwave cooking
KW - NaCl
KW - Temperature distribution
N1 - Accession Number: 23554141; Jeong, J.Y. 1 Lee, E.S. 2 Choi, J.H. 1 Lee, J.Y. 3 Kim, J.M. 1 Min, S.G. 1 Chae, Y.C. 4 Kim, C.J. 1; Email Address: kimcj@konkuk.ac.kr; Affiliation: 1: Department of Food Science and Biotechnology of Animal Resources, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea 2: Department of Applied Microbiology and Food Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8 3: Korea Food and Drug Administration, Division of Food Standard, Center for Food Standard Evaluation, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-704, Republic of Korea 4: Department of Hotel Culinary Arts, Ulsan Technical College, 160 Whajung-dong, Dong-gu, Ulsan 682-090, Republic of Korea; Source Info: Mar2007, Vol. 75 Issue 3, p415; Subject Term: PORK; Subject Term: FOOD -- Fat content; Subject Term: MEAT; Subject Term: FOOD science; Author-Supplied Keyword: Fat level; Author-Supplied Keyword: Ground pork patties; Author-Supplied Keyword: Microwave cooking; Author-Supplied Keyword: NaCl; Author-Supplied Keyword: Temperature distribution; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 311612 Meat Processed from Carcasses; NAICS/Industry Codes: 311611 Animal (except Poultry) Slaughtering; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.meatsci.2006.08.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23554141&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doney, Brent
AU - Greskevitch, Mark
AU - Groce, Dennis
AU - Syamlal, Girija
AU - Bang, Ki Moon
T1 - Respirator Use and Practices in Primary Metal Operations.
JO - Metal Producing & Processing
JF - Metal Producing & Processing
Y1 - 2007/03//Mar/Apr2007
VL - 45
IS - 2
M3 - Article
SP - 31
EP - 32
PB - Penton Publishing
SN - 15471411
AB - The article provides information on the development surrounding the survey conducted by U.S. Labor Dept's Bureau of Labor Statistics and the National Institute for Occupational Safety and Health (NIOSH) regarding respirator use and practices. The findings of the survey raised questions on how these practices compare with Occupational Safety and Health Administration regulations and NIOSH recommendations. Furthermore, the survey did not allow determination of particular substances.
KW - BREATHING apparatus
KW - INDUSTRIAL safety
KW - INDUSTRIAL policy
KW - STEEL industry
KW - SURVEYS
KW - UNITED States
N1 - Accession Number: 24635892; Doney, Brent 1; Greskevitch, Mark 1; Groce, Dennis 2; Syamlal, Girija 1; Bang, Ki Moon 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV; 2: EG&G Technical Services Inc.; Issue Info: Mar/Apr2007, Vol. 45 Issue 2, p31; Thesaurus Term: BREATHING apparatus; Thesaurus Term: INDUSTRIAL safety; Thesaurus Term: INDUSTRIAL policy; Thesaurus Term: STEEL industry; Subject Term: SURVEYS; Subject: UNITED States; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 331221 Rolled Steel Shape Manufacturing; Number of Pages: 2p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Elespuru, R.K.
AU - Sankaranarayanan, K.
T1 - New approaches to assessing the effects of mutagenic agents on the integrity of the human genome
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2007/03//
VL - 616
IS - 1/2
M3 - Article
SP - 83
EP - 89
SN - 00275107
AB - Abstract: Heritable genetic alterations, although individually rare, have a substantial collective health impact. Approximately 20% of these are new mutations of unknown cause. Assessment of the effect of exposures to DNA damaging agents, i.e. mutagenic chemicals and radiations, on the integrity of the human genome and on the occurrence of genetic disease remains a daunting challenge. Recent insights may explain why previous examination of human exposures to ionizing radiation, as in Hiroshima and Nagasaki, failed to reveal heritable genetic effects. New opportunities to assess the heritable genetic damaging effects of environmental mutagens are afforded by: (1) integration of knowledge on the molecular nature of genetic disorders and the molecular effects of mutagens; (2) the development of more practical assays for germline mutagenesis; (3) the likely use of population-based genetic screening in personalized medicine. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENESIS
KW - HUMAN genome
KW - IONIZING radiation
KW - GENETIC disorders
KW - Environmental mutagenesis
KW - Germ cell mutagenesis
KW - Heritable alterations
KW - Human genetic disease
KW - Integrity of the genome
KW - Molecular epidemiology
N1 - Accession Number: 23950583; Elespuru, R.K. 1; Email Address: Rosalie.Elespuru@fda.hhs.gov Sankaranarayanan, K. 2; Affiliation: 1: Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, The Netherlands 2: Department of Toxicogenetics, Leiden University Medical Centre, Einthovenweg, Building 2, Post Zone S-4-P, Post Office Box 9600, 2300 RC Leiden, The Netherlands; Source Info: Mar2007, Vol. 616 Issue 1/2, p83; Subject Term: MUTAGENESIS; Subject Term: HUMAN genome; Subject Term: IONIZING radiation; Subject Term: GENETIC disorders; Author-Supplied Keyword: Environmental mutagenesis; Author-Supplied Keyword: Germ cell mutagenesis; Author-Supplied Keyword: Heritable alterations; Author-Supplied Keyword: Human genetic disease; Author-Supplied Keyword: Integrity of the genome; Author-Supplied Keyword: Molecular epidemiology; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2006.11.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23950583&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Fuscoe, James C.
T1 - Transcriptional profiling for understanding the basis of mitochondrial involvement in disease and toxicity using the mitochondria-specific MitoChip
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2007/03//
VL - 616
IS - 1/2
M3 - Article
SP - 210
EP - 212
SN - 00275107
AB - Abstract: It is well documented that mitochondrial dysfunction significantly contributes to a number of degenerative diseases, metabolic disorders, and drug- and chemical-induced toxicities. Thus far, information gained by several molecular and biochemical techniques used to delineate the mechanism of impaired mitochondrial activity underlying different diseases and various toxicities is still limited due to their low throughput potential. Here, we describe the development of mitochondria-specific mouse oligonucleotide microarray and its potential to define mechanisms of disease progression and drug toxicities associated with mitochondrial dysfunction at both nuclear and mitochondrial genome level. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIA
KW - DNA microarrays
KW - DEGENERATION (Pathology)
KW - METABOLIC disorders
KW - Microarray
KW - Mitochondrial dysfunction
KW - Mouse MitoChip
N1 - Accession Number: 23950597; Desai, Varsha G.; Email Address: varsha.desai@fda.hhs.gov Fuscoe, James C. 1; Affiliation: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-130, Jefferson, AR 72079, United States; Source Info: Mar2007, Vol. 616 Issue 1/2, p210; Subject Term: MITOCHONDRIA; Subject Term: DNA microarrays; Subject Term: DEGENERATION (Pathology); Subject Term: METABOLIC disorders; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Mitochondrial dysfunction; Author-Supplied Keyword: Mouse MitoChip; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2006.11.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23950597&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Voeltz, Gia K.
AU - Prinz, William A.
T1 - Sheets, ribbons and tubules — how organelles get their shape.
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
Y1 - 2007/03//
VL - 8
IS - 3
M3 - Article
SP - 258
EP - 264
PB - Nature Publishing Group
SN - 14710072
AB - Most membrane-bound organelles have elaborate, dynamic shapes and often include regions with distinct morphologies. These complex structures are relatively conserved throughout evolution, which indicates that they are important for optimal organelle function. Various mechanisms of determining organelle shape have been proposed — proteins that stabilize highly curved membranes, the tethering of organelles to other cellular components and the regulation of membrane fission and fusion might all contribute. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Molecular Cell Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL organelles
KW - CYTOPLASM
KW - CELLS
KW - PROTOPLASM
KW - CYTOLOGY
KW - MOLECULAR biology
N1 - Accession Number: 24162227; Voeltz, Gia K. 1; Email Address: gia.voeltz@colorado.edu Prinz, William A. 2; Email Address: wprinz@helix.nih.gov; Affiliation: 1: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA 2: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA; Source Info: Mar2007, Vol. 8 Issue 3, p258; Subject Term: CELL organelles; Subject Term: CYTOPLASM; Subject Term: CELLS; Subject Term: PROTOPLASM; Subject Term: CYTOLOGY; Subject Term: MOLECULAR biology; Number of Pages: 7p; Illustrations: 5 Diagrams; Document Type: Article
L3 - 10.1038/nrm2119
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24162227&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Sangho
AU - Joshi, Anjali
AU - Nagashima, Kunio
AU - Freed, Eric O.
AU - Hurley, James H.
T1 - Structural basis for viral late-domain binding to Alix.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2007/03//
VL - 14
IS - 3
M3 - Article
SP - 194
EP - 199
PB - Nature Publishing Group
SN - 15459993
AB - The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPxnLxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360–702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 α-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN binding
KW - HIV (Viruses)
KW - GENETIC transcription
KW - TOPOLOGY
KW - PEPTIDES
KW - ASEXUAL reproduction
KW - HYDROPHOBIC surfaces
N1 - Accession Number: 24231013; Lee, Sangho 1 Joshi, Anjali 2 Nagashima, Kunio 3 Freed, Eric O. 2 Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), US Department of Health and Human Services, Bethesda, Maryland 20892, USA 2: Virus-Cell Interaction Section, HIV Drug Resistance Program, SAIC-Frederick, National Cancer Institute-Frederick, NIH, US Department of Health and Human Services, Frederick, Maryland 21702, USA 3: Image Analysis Laboratory, Research Technology Program, SAIC-Frederick, National Cancer Institute-Frederick, NIH, US Department of Health and Human Services, Frederick, Maryland 21702, USA; Source Info: Mar2007, Vol. 14 Issue 3, p194; Subject Term: PROTEIN binding; Subject Term: HIV (Viruses); Subject Term: GENETIC transcription; Subject Term: TOPOLOGY; Subject Term: PEPTIDES; Subject Term: ASEXUAL reproduction; Subject Term: HYDROPHOBIC surfaces; Number of Pages: 6p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/nsmb1203
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24231013&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowler, Rosemarie M.
AU - Nakagawa, Sanae
AU - Drezgic, Marija
AU - Roels, Harry A.
AU - Park, Robert M.
AU - Diamond, Emily
AU - Mergler, Donna
AU - Bouchard, Maryse
AU - Bowler, Russell P.
AU - Koller, William
T1 - Sequelae of fume exposure in confined space welding: A neurological and neuropsychological case series
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2007/03//
VL - 28
IS - 2
M3 - Article
SP - 298
EP - 311
SN - 0161813X
AB - Abstract: Welding fume contains manganese (Mn) which is known to be bio-available to and neurotoxic for the central nervous system. Although an essential metal, Mn overexposure may cause manganism, a parkinsonian syndrome. The present welder study sought to improve the clinical portrait of manganism and to determine dose–effect relationships. The welders were employed in the construction of the new Bay Bridge (San Francisco) and welded in confined spaces for up to 2 years with minimal protection and poor ventilation. Neurological, neuropsychological, neurophysiological, and pulmonary examinations were given to 49 welders. Clinical cases were selected on the basis of apriori defined criteria pertaining to welding history and neurological/neuropsychological features. Among the 43 eligible welders, 11 cases of manganism were identified presenting with the following symptoms: sleep disturbance, mood changes, bradykinesia, headaches, sexual dysfunction, olfaction loss, muscular rigidity, tremors, hallucinations, slurred speech, postural instability, monotonous voice, and facial masking. Significant associations between outcome variables and cumulative exposure index (CEI) or blood Mn (MnB) were obtained with CEI for variables implicating attention and concentration, working and immediate memory, cognitive flexibility, and verbal learning; and with MnB for executive function, cognitive flexibility, visuo-spatial construction ability, and visual contrast sensitivity. This study strongly suggests that neuropsychological features contribute in a dose–effect related way to the portrait of manganism usually characterized by tremor, loss in balance, diminished cognitive performance, and signs and symptoms of parkinsonism. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WELDING -- Health aspects
KW - MANGANESE
KW - CENTRAL nervous system
KW - SYMPTOMATIC Parkinson's disease
KW - WELDERS (Persons)
KW - SEXUAL dysfunction
KW - HALLUCINATIONS & illusions
KW - PARKINSON'S disease
KW - Adults
KW - CATSYS
KW - Clinical cases
KW - Emotional status
KW - Manganese exposure
KW - Motor
KW - Neurological
KW - Neuropsychological
KW - Vision
N1 - Accession Number: 25341685; Bowler, Rosemarie M. 1; Email Address: rbowl@sfsu.edu Nakagawa, Sanae 1 Drezgic, Marija 1 Roels, Harry A. 2 Park, Robert M. 3 Diamond, Emily 4 Mergler, Donna 5 Bouchard, Maryse 5 Bowler, Russell P. 6 Koller, William 7; Affiliation: 1: San Francisco State University, San Francisco, CA, United States 2: Industrial Toxicology and Occupational Medicine Unit, School of Public Health, Université catholique de Louvain, Brussels, Belgium 3: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, United States 4: The Wright Institute, Berkeley, CA, United States 5: University of Quebec at Montreal, Montreal, Quebec, Canada 6: National Jewish Medical and Research Center, Denver, Colorado, United States 7: University of North Carolina, Department of Neurology, Chapel Hill, NC, United States; Source Info: Mar2007, Vol. 28 Issue 2, p298; Subject Term: WELDING -- Health aspects; Subject Term: MANGANESE; Subject Term: CENTRAL nervous system; Subject Term: SYMPTOMATIC Parkinson's disease; Subject Term: WELDERS (Persons); Subject Term: SEXUAL dysfunction; Subject Term: HALLUCINATIONS & illusions; Subject Term: PARKINSON'S disease; Author-Supplied Keyword: Adults; Author-Supplied Keyword: CATSYS; Author-Supplied Keyword: Clinical cases; Author-Supplied Keyword: Emotional status; Author-Supplied Keyword: Manganese exposure; Author-Supplied Keyword: Motor; Author-Supplied Keyword: Neurological; Author-Supplied Keyword: Neuropsychological; Author-Supplied Keyword: Vision; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.neuro.2006.11.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106274547
T1 - Device safety. Prevent dangerous hemodialysis catheter disconnections.
AU - Zeigler SA
Y1 - 2007/03//
N1 - Accession Number: 106274547. Language: English. Entry Date: 20070427. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Catheter Care, Vascular
KW - Catheters, Dialysis -- Adverse Effects
KW - Equipment Safety
KW - Hemodialysis
KW - Dialysis Patients
KW - Embolism, Air
SP - 70
EP - 70
JO - Nursing
JF - Nursing
JA - NURSING
VL - 37
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 17546790.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106274547&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hong Fang
AU - Xiaohui Fan
AU - Lei Guo
AU - Leming Shi
AU - Roger Perkins
AU - Weigong Ge
AU - Yvonne P. Dragan
AU - Weida Tong
T1 - Self-self Hybridization As An Alternative Experiment Design to Dye Swap for Two-color Microarrays.
JO - OMICS: A Journal of Integrative Biology
JF - OMICS: A Journal of Integrative Biology
Y1 - 2007/03//
VL - 11
IS - 1
M3 - Article
SP - 14
EP - 24
SN - 15362310
AB - Dye-specific bias effects, commonly observed in the two-color microarrayplatform, are normally corrected using the dye swap design. This design, however, is relatively expensive and labor-intensive. We propose a self-self hybridizationdesign as an alternative to the dye swap design. In this design, the treated and control samples are labeled with Cy5 and Cy3 (or Cy3 and Cy5), respectively, without dye swap, along with a set of self-self hybridizations on the control sample. We compare this design with the dye swap design through investigation of mouse primary hepatocytes treated with three peroxisome proliferator–activated receptor-alpha (PPARα) agonists at three dose levels. Using Agilent's Whole Mouse Genome microarray, differentially expressed genes (DEG) were determined for both the self-self hybridization and dye swap designs. The DEG concordance between the two designs was over 80 across each dose treatment and chemical. Furthermore, 90 of DEG-associated biological pathways were in common between the designs, indicating that biological interpretations would be consistent. The reduced labor and expense for the self-self hybridization design make it an efficient substitute for the dye swap design. For example, in larger toxicogenomic studies, only about half the chips are required for the self-self hybridization design compared to that needed in the dye swap design. [ABSTRACT FROM AUTHOR]
AB - Copyright of OMICS: A Journal of Integrative Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYBRIDIZATION
KW - DNA microarrays
KW - LIVER cells
KW - MICE
N1 - Accession Number: 24725419; Hong Fang 1 Xiaohui Fan 2 Lei Guo 2 Leming Shi 2 Roger Perkins 1 Weigong Ge 2 Yvonne P. Dragan 2 Weida Tong 2; Affiliation: 1: Division of Bioinformatics, Z-Tech Corporation, Jefferson, Arkansas. 2: Division of Systems Toxicology, National Center for Toxicological Research (NCTR), Food and Drug Administration, Jefferson, Arizona.; Source Info: Mar2007, Vol. 11 Issue 1, p14; Subject Term: HYBRIDIZATION; Subject Term: DNA microarrays; Subject Term: LIVER cells; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106018116
T1 - FDA Drug Approval Summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer.
AU - Cohen MH
AU - Gootenberg J
AU - Keegan P
AU - Pazdur R
Y1 - 2007/03//
N1 - Accession Number: 106018116. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; CEU; clinical trial; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607837.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Colorectal Neoplasms -- Drug Therapy
KW - Adult
KW - Aged
KW - Antibodies, Monoclonal -- Administration and Dosage
KW - Antibodies, Monoclonal -- Adverse Effects
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Female
KW - Fluorouracil -- Administration and Dosage
KW - Infusions, Intravenous
KW - Injections, Intravenous
KW - Leucovorin -- Administration and Dosage
KW - Male
KW - Middle Age
KW - Organic Chemicals -- Administration and Dosage
KW - Survival Analysis
KW - Treatment Outcomes
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 356
EP - 361
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 12
IS - 3
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On June 20, 2006, the U.S. Food and Drug Administration (FDA) approved bevacizumab (Avastin(R); Genentech, Inc., South San Francisco, CA), administered in combination with FOLFOX4 (5-fluorouracil, leucovorin, and oxaliplatin) for the second-line treatment of metastatic carcinoma of the colon or rectum. Efficacy and safety were demonstrated in one Eastern Cooperative Oncology Group (ECOG) open-label, multicenter, randomized, three-arm, active-controlled trial enrolling 829 adult patients. Patients had received a fluoropyrimidine- and irinotecan-based regimen as initial therapy for metastatic disease; or they had received prior adjuvant irinotecan-based chemotherapy and had recurred within 6 months of completing therapy. Treatments included bevacizumab, 10 mg/kg, as a 90-minute i.v. infusion on day 1, every 2 weeks, either alone or in combination with FOLFOX4, or FOLFOX4 alone. The bevacizumab monotherapy arm was closed to accrual after an interim efficacy analysis suggested a possibly shorter survival in that arm. Overall survival (OS), the primary study endpoint, was significantly longer for patients receiving bevacizumab in combination with FOLFOX4 than for those receiving FOLFOX4 alone. The objective response rate was significantly higher in the FOLFOX4 plus bevacizumab arm than in the FOLFOX4 alone arm. The duration of response was approximately 6 months for both treatment arms. Patients treated with the bevacizumab combination were also reported, based on investigator assessment, to have significantly longer progression-free survival. There were no new bevacizumab safety signals. The most serious, and sometimes fatal, bevacizumab toxicities are gastrointestinal perforation, wound-healing complications, hemorrhage, arterial thromboembolic events, hypertensive crisis, nephrotic syndrome, and congestive heart failure. Disclosure of potential conflicts of interest is found at the end of this article.
SN - 1083-7159
AD - U.S. Food and Drug Administration, HFD-150, 5600 Fishers Lane, Rockville, Maryland 20857, USA. cohenma@cder.fda.gov.
U2 - PMID: 17405901.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106018116&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Devadas, Krishnakumar
AU - Boykins, Robert A.
AU - Hewlett, Indira K.
AU - Wood, Owen L.
AU - Clouse, Kathleen A.
AU - Yamada, Kenneth M.
AU - Dhawan, Subhash
T1 - Antibodies against a multiple-peptide conjugate comprising chemically modified human immunodeficiency virus type-1 functional Tat peptides inhibit infection
JO - Peptides
JF - Peptides
Y1 - 2007/03//
VL - 28
IS - 3
M3 - Article
SP - 496
EP - 504
SN - 01969781
AB - Abstract: We demonstrated recently that selective side-chain modification of functional cysteine-rich (Tat21–40) and arginine-rich (Tat53–68) domains of the HIV-1 Tat protein blocks pathogenic activities of these peptides while retaining their immunological characteristics. In the present study, we have synthesized a multiple-peptide conjugate system comprising modified Tat21–40 and Tat53–68 peptides (HIV-1-Tat-MPC). Immunization of mice with this highly homogeneous 10.7kDa HIV-1-Tat-MPC synthetic construct induced an effective immune response in mice. The antibodies generated against HIV-1-Tat-MPC efficiently suppressed Tat-induced viral replication and significantly reduced HIV-associated cytopathic effects in human monocytes. These results indicate that epitope-specific antibodies directed against functional sites of Tat protein using non-pathogenic peptides inhibit HIV pathogenesis. The HIV-1-Tat-MPC, therefore, has potential for the development of a safe, effective, and economical therapeutic vaccine to reduce the progression of HIV infection. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - AIDS (Disease)
KW - RODENTS
KW - VIRAL replication
KW - AIDS
KW - HIV-Tat
KW - Peptides
KW - Vaccination
N1 - Accession Number: 23946224; Devadas, Krishnakumar 1 Boykins, Robert A. 2 Hewlett, Indira K. 1 Wood, Owen L. 1 Clouse, Kathleen A. 3 Yamada, Kenneth M. 4 Dhawan, Subhash 1; Email Address: subhash.dhawan@fda.hhs.gov; Affiliation: 1: Immunopathogenesis Section, Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States 2: Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States 3: Laboratory of Cell Biology, Center for Drug Evaluation and Research, Bethesda, MD 20892, United States 4: Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States; Source Info: Mar2007, Vol. 28 Issue 3, p496; Subject Term: HIV infections; Subject Term: AIDS (Disease); Subject Term: RODENTS; Subject Term: VIRAL replication; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: HIV-Tat; Author-Supplied Keyword: Peptides; Author-Supplied Keyword: Vaccination; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.peptides.2006.11.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Uhl, Kathleen
AU - Trontell, Anne
AU - Kennedy, Dianne
T1 - Risk minimization practices for pregnancy prevention: understanding risk, selecting tools.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/03//
VL - 16
IS - 3
M3 - Article
SP - 337
EP - 348
SN - 10538569
AB - According to the March of Dimes, approximately 4% (1/28) of babies are born in the US each year with a birth defect. For the majority of birth defects the etiology is unknown, although chemicals, including drug exposures, probably account for less than 1% of all birth defects. The identification of potential human teratogenicity during drug development is important because drug-induced adverse fetal effects are potentially preventable with the application of risk assessment strategies and risk minimization tools and programs to minimize risk of pregnancy exposure while preserving access to drug benefits; risk assessment and risk minimization together comprise risk management. It is important that risk minimization programs intended to limit fetal exposure use a consistent approach and are tailored to the product-specific risk concerns in order to optimize the benefit-risk balance for a particular drug. This paper highlights general considerations in developing specific risk minimization programs to prevent fetal drug exposure including the relative advantages and disadvantages of each strategy. Published in 2006 by John Wiley and Sons Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708298; Uhl, Kathleen 1; Trontell, Anne 2; Kennedy, Dianne 3; Affiliations: 1: US Food and Drug Administration, Office of Women's Health, Rockville, MD, USA; 2: Agency for Healthcare Research and Quality, Center for Outcomes and Evidence, Rockville, MD, USA; 3: US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, USA; Issue Info: Mar2007, Vol. 16 Issue 3, p337; Number of Pages: 12p; Document Type: Article
L3 - 10.1002/pds.1312
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=64708298&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schech, Stephanie
AU - Graham, David
AU - Staffa, Judy
AU - Andrade, Susan E.
AU - Grenade, Lois La
AU - Burgess, Margaret
AU - Blough, David
AU - Stergachis, Andy
AU - Chan, K. Arnold
AU - Platt, Richard
AU - Shatin, Deborah
T1 - Risk factors for statin-associated rhabdomyolysis.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/03//
VL - 16
IS - 3
M3 - Article
SP - 352
EP - 358
SN - 10538569
AB - Purpose To identify and characterize risk factors for rhabdomyolysis in patients prescribed statin monotherapy or statin plus fibrate therapy. Methods A nested case-control study was conducted within a cohort of 252 460 new users of lipid-lowering medications across 11 geographically dispersed U.S. health plans. Twenty-one cases of rhabdomyolysis confirmed by medical record review were compared to 200 individually matched controls without rhabdomyolysis. A conditional logistic regression model was applied to evaluate the effects of age, gender, comorbidities, concurrent medication use, dosage, and duration of statin use on the development of rhabdomyolysis. Results Statin users 65 years of age and older have four times the risk of hospitalization for rhabdomyolysis than those under age 65 (odds ratio (OR) = 4.36, 95% confidence interval (CI): 1.5,14.1). We also observed a joint effect of high statin dosage and renal disease ( p = 0.022). When these two variables were added to the model with age, we obtained an OR of 5.73 for dosage (95%CI: 0.63, 52.6) and 6.26 for renal disease (95%CI: 0.46, 63.38). Although not statistically significant, we did observe a greater than twofold increase in risk for rhabdomyolysis among females (OR = 2.53, 95%CI: 0.91, 7.32). Conclusions Findings of this study indicate that older age is a risk factor for rhabdomyolysis among statin users. Although the evidence is not as strong, high statin dosage, renal disease, and female gender may be additional risk factors. Patients at higher risk of developing rhabdomyolysis should be closely monitored for signs and symptoms of the disease. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708299; Schech, Stephanie 1; Graham, David 2; Staffa, Judy 2; Andrade, Susan E. 3; Grenade, Lois La 2; Burgess, Margaret 1; Blough, David 4; Stergachis, Andy 4,5; Chan, K. Arnold 6; Platt, Richard 7; Shatin, Deborah 1; Affiliations: 1: Center for Health Care Policy and Evaluation, Eden Prairie, MN, USA; 2: Office of Drug Safety, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; 3: Meyers Primary Care Institute-Fallon Foundation and University of Massachusetts Medical School, Worcester, MA, USA; 4: Department of Pharmacy, University of Washington, Seattle, WA, USA; 5: Department of Epidemiology, University of Washington, Seattle, WA, USA; 6: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; 7: Harvard Pilgrim Health Care, Harvard Medical School, Channing Laboratory, and Brigham and Women's Hospital, Boston, MA, USA; Issue Info: Mar2007, Vol. 16 Issue 3, p352; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1287
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fu, Peter P.
AU - Xia, Qingsu
AU - Yin, Jun Jie
AU - Cherng, Shu-Hui
AU - Yan, Jian
AU - Mei, Nan
AU - Chen, Tao
AU - Boudreau, Mary D.
AU - Howard, Paul C.
AU - Wamer, Wayne G.
T1 - Photodecomposition of Vitamin A and Photobiological Implications for the Skin.
JO - Photochemistry & Photobiology
JF - Photochemistry & Photobiology
Y1 - 2007/03//Mar/Apr2007
VL - 83
IS - 2
M3 - Article
SP - 409
EP - 424
SN - 00318655
AB - Vitamin A (retinol), an essential human nutrient, plays an important role in cellular differentiation, regulation of epidermal cell growth and normal cell maintenance. In addition to these physiological roles, vitamin A has a rich photochemistry. Photoisomerization of vitamin A, involved in signal transduction for vision, has been extensively investigated. The biological effects of light-induced degradation of vitamin A and formation of reactive species are less understood and may be important for light-exposed tissues, such as the skin. Photochemical studies have demonstrated that excitation of retinol or its esters with UV light generates a number of reactive species including singlet oxygen and superoxide radical anion. These reactive oxygen species have been shown to damage a number of cellular targets, including lipids and DNA. Consistent with the potential for damaging DNA, retinyl palmitate has been shown to be photomutagenic in an in vitro test system. The results of mechanistic studies were consistent with mutagenesis through oxidative damage. Vitamin A in the skin resides in a complex environment that in many ways is very different from the chemical environment in solution and in in vitro test systems. Relevant clinical studies or studies in animal models are therefore needed to establish whether the pro-oxidant activity of photoexcited vitamin A is observed in vivo, and to assess the related risks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DECOMPOSITION (Chemistry)
KW - VITAMIN A in human nutrition
KW - PHOTOCHEMISTRY
KW - EPIDERMAL growth factor
KW - PHOTOISOMERIZATION
KW - SKIN -- Inflammation
KW - PHOTOOXIDATIVE stress
N1 - Accession Number: 24594407; Fu, Peter P. 1; Email Address: peter.fu@fda.hhs.gov Xia, Qingsu 1 Yin, Jun Jie 2 Cherng, Shu-Hui 1 Yan, Jian 1 Mei, Nan 1 Chen, Tao 1 Boudreau, Mary D. 1 Howard, Paul C. 1 Wamer, Wayne G. 2; Affiliation: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD; Source Info: Mar/Apr2007, Vol. 83 Issue 2, p409; Subject Term: DECOMPOSITION (Chemistry); Subject Term: VITAMIN A in human nutrition; Subject Term: PHOTOCHEMISTRY; Subject Term: EPIDERMAL growth factor; Subject Term: PHOTOISOMERIZATION; Subject Term: SKIN -- Inflammation; Subject Term: PHOTOOXIDATIVE stress; Number of Pages: 16p; Illustrations: 11 Diagrams, 9 Graphs; Document Type: Article
L3 - 10.1562/2006-10-23-IR-1065
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24594407&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Geoffrey M.
AU - Petersen, Ann M.
AU - Sievert, Jennifer
AU - Mehler, Louise N.
AU - Das, Rupali
AU - Harter, Lucy C.
AU - Romoli, Cinzia
AU - Becker, Alan
AU - Ball, Cynthia
AU - Male, Dorilee
AU - Schwartz, Abby
AU - Lackovic, Michelle
T1 - Acute Pesticide Poisoning in the U.S. Retail Industry, 1998-2004.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007/03//Mar/Apr2007
VL - 122
IS - 2
M3 - Article
SP - 232
EP - 244
SN - 00333549
AB - Objective. This study was conducted to describe the national magnitude and characteristics of acute pesticide poisoning among workers and customers in retail establishments. Methods. Analyses included retail employees 15-64 years of age and customers with acute pesticide poisoning identified from the Sentinel Event Notification System for Occupational Risks-Pesticides (SENSOR-Pesticides) and California Department of Pesticide Regulation from 1998 to 2004. Pesticide poisoning incidence rates and incidence rate ratios (IRR) were calculated. Results. A total of 325 cases of acute pesticide poisoning were identified. Of these cases, 287 (88%) were retail employees and 38 (12%) were customers. Overall, retail employees had a significantly lower acute pesticide poisoning incidence rate compared with non-agricultural, non-retail employees (IRR=0.53; 95% confidence interval 0.47, 0.59). However, significantly elevated pesticide poisoning incidence rates were observed for four retail occupations (janitors, stock handlers/baggers, bakery/deli clerks, and shipping/receiving handlers). In addition, workers employed in two retail industry sectors (farm supply stores and hardware stores) had significantly elevated acute pesticide poisoning incidence rates. Incidence rates among the retail employees demonstrated a quadratic trend, monotonically decreasing from 1998 to 2000 and monotonically increasing from 2000 to 2003. The rates appear to have leveled off in 2003 and 2004. Conclusions. Preventive measures to decrease acute pesticide poisoning incidence in the retail sector include adoption of unbreakable and tear-resistant container requirements, increased utilization of integrated pest management strategies, and advisement to store managers, employees, and customers about poisoning prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL toxicology
KW - PESTICIDES
KW - RETAIL industry -- Employees
KW - CONSUMERS
KW - PREVENTIVE medicine
KW - UNITED States
N1 - Accession Number: 24160913; Calvert, Geoffrey M. 1,2; Email Address: jac6@cdc.gov Petersen, Ann M. 1 Sievert, Jennifer 3 Mehler, Louise N. 4 Das, Rupali 5 Harter, Lucy C. 6 Romoli, Cinzia 7 Becker, Alan 8 Ball, Cynthia 9 Male, Dorilee 10 Schwartz, Abby 11 Lackovic, Michelle 12; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 2: National Institute for Occupational Safety and Health, 4676 Columbia Pkwy., R-17, Cincinnati, OH 45226 3: Environmental and Injury Epidemiology and Toxicology Branch, Texas Department of State Health Services, Austin, TX 4: Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA 5: Occupational Health Branch, California Department of Health Services, Oakland, CA 6: Office of Environmental Health and Safety, Washington State Department of Health, Olympia, WA 7: Office of Disease Prevention and Epidemiology, Oregon Department of Human Services, Portland, OR 8: Bureau of Community Environmental Health, Florida Department of Health, Tallahassee, FL 9: Department of Occupational Health Sciences, University of Texas Health Center, Tyler, TX 10: Bureau of Occupational Health, New York State Department of Health, Troy, NY 11: Division of Environmental and Occupational Epidemiology, Michigan Department of Community Health, Lansing, MI 12: Louisiana Department of Health and Hospitals, New Orleans, LA; Source Info: Mar/Apr2007, Vol. 122 Issue 2, p232; Subject Term: INDUSTRIAL toxicology; Subject Term: PESTICIDES; Subject Term: RETAIL industry -- Employees; Subject Term: CONSUMERS; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 13p; Illustrations: 8 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105982540
T1 - Acute pesticide poisoning in the U.S. retail industry, 1998-2004.
AU - Calvert GM
AU - Petersen AM
AU - Sievert J
AU - Mehler LN
AU - Das R
AU - Harter LC
AU - Romoli C
AU - Becker A
AU - Ball C
AU - Male D
AU - Schwartz A
AU - Lackovic M
Y1 - 2007/03//Mar/Apr2007
N1 - Accession Number: 105982540. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. NLM UID: 9716844.
KW - Business
KW - Occupational Exposure -- Adverse Effects
KW - Organic Chemicals -- Poisoning
KW - Pesticides -- Poisoning
KW - Product Packaging -- Standards
KW - Acute Disease
KW - Adolescence
KW - Adult
KW - Female
KW - Food Contamination
KW - Incidence
KW - Male
KW - Middle Age
KW - Occupational Exposure
KW - Organic Chemicals
KW - Pesticides
KW - Risk Factors
KW - United States
KW - Human
SP - 232
EP - 244
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 122
IS - 2
PB - Sage Publications Inc.
AB - Objective. This study was conducted to describe the national magnitude and characteristics of acute pesticide poisoning among workers and customers in retail establishments.Methods. Analyses included retail employees 15-64 years of age and customers with acute pesticide poisoning identified from the Sentinel Event Notification System for Occupational Risks-Pesticides (SENSOR-Pesticides) and California Department of Pesticide Regulation from 1998 to 2004. Pesticide poisoning incidence rates and incidence rate ratios (IRR) were calculated.Results. A total of 325 cases of acute pesticide poisoning were identified. Of these cases, 287 (88%) were retail employees and 38 (12%) were customers. Overall, retail employees had a significantly lower acute pesticide poisoning incidence rate compared with non-agricultural, non-retail employees (IRR=0.53; , 95% confidence interval 0.47, 0.59). However, significantly elevated pesticide poisoning incidence rates were observed for four retail occupations (janitors, stock handlers/baggers, bakery/deli clerks, and shipping/receiving handlers). In addition, workers employed in two retail industry sectors (farm supply stores and hardware stores) had significantly elevated acute pesticide poisoning incidence rates. Incidence rates among the retail employees demonstrated a quadratic trend, monotonically decreasing from 1998 to 2000 and monotonically increasing from 2000 to 2003. The rates appear to have leveled off in 2003 and 2004.Conclusions. Preventive measures to decrease acute pesticide poisoning incidence in the retail sector include adoption of unbreakable and tear-resistant container requirements, increased utilization of integrated pest management strategies, and advisement to store managers, employees, and customers about poisoning prevention.
SN - 0033-3549
AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy., R-17, Cincinnati, OH 45226; jac6@cdc.gov
U2 - PMID: 17357366.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105982540&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Daniel Benz, R.
AU - Contrera, Joseph F.
T1 - A comprehensive model for reproductive and developmental toxicity hazard identification: I. Development of a weight of evidence QSAR database
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/03//
VL - 47
IS - 2
M3 - Article
SP - 115
EP - 135
SN - 02732300
AB - Abstract: A weight of evidence (WOE) reproductive and developmental toxicology (reprotox) database was constructed that is suitable for quantitative structure–activity relationship (QSAR) modeling and human hazard identification of untested chemicals. The database was derived from multiple publicly available reprotox databases and consists of more than 10,000 individual rat, mouse, or rabbit reprotox tests linked to 2134 different organic chemical structures. The reprotox data were classified into seven general classes (male reproductive toxicity, female reproductive toxicity, fetal dysmorphogenesis, functional toxicity, mortality, growth, and newborn behavioral toxicity), and 90 specific categories as defined in the source reprotox databases. Each specific category contained over 500 chemicals, but the percentage of active chemicals was low, generally only 0.1–10%. The mathematical WOE model placed greater significance on confirmatory observations from repeat experiments, chemicals with multiple findings within a category, and the categorical relatedness of the findings. Using the weighted activity scores, statistical analyses were performed for specific data sets to identify clusters of categories that were correlated, containing similar profiles of active and inactive chemicals. The analysis revealed clusters of specific categories that contained chemicals that were active in two or more mammalian species (trans-species). Such chemicals are considered to have the highest potential risk to humans. In contrast, some specific categories exhibited only single species-specific activities. Results also showed that the rat and mouse were more susceptible to dysmorphogenesis than rabbits (6.1- and 3.6-fold, respectively). [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Structure-activity relationships (Biochemistry)
KW - Effect of chemicals on human reproduction
KW - Reproductive toxicology
KW - Developmental toxicology
KW - Developmental toxicity
KW - Dysmorphogenesis
KW - QSAR
KW - Quantitative structure–activity relationships
KW - Reproductive toxicity
KW - Reprotox
KW - Teratogenicity
KW - Weight of evidence
N1 - Accession Number: 23956780; Matthews, Edwin J.; Email Address: edwin.matthews@fda.hhs.gov; Kruhlak, Naomi L. 1; Daniel Benz, R. 1; Contrera, Joseph F. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA; Issue Info: Mar2007, Vol. 47 Issue 2, p115; Thesaurus Term: Structure-activity relationships (Biochemistry); Subject Term: Effect of chemicals on human reproduction; Subject Term: Reproductive toxicology; Subject Term: Developmental toxicology; Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: Dysmorphogenesis; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Quantitative structure–activity relationships; Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Reprotox; Author-Supplied Keyword: Teratogenicity; Author-Supplied Keyword: Weight of evidence; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.11.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23956780&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Daniel Benz, R.
AU - Ivanov, Julian
AU - Klopman, Gilles
AU - Contrera, Joseph F.
T1 - A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/03//
VL - 47
IS - 2
M3 - Article
SP - 136
EP - 155
SN - 02732300
AB - Abstract: This report describes the construction, optimization and validation of a battery of quantitative structure–activity relationship (QSAR) models to predict reproductive and developmental (reprotox) hazards of untested chemicals. These models run with MC4PC software to predict seven general reprotox classes: male and female reproductive toxicity, fetal dysmorphogenesis, functional toxicity, mortality, growth, and newborn behavioral toxicity. The reprotox QSARs incorporate a weight of evidence paradigm using rats, mice, and rabbit reprotox study data and are designed to identify trans-species reprotoxicants. The majority of the reprotox QSARs exhibit good predictive performance properties: high specificity (>80%), low false positives (<20%), significant receiver operating characteristic (ROC) values (>2.00), and high coverage (>80%) in 10% leave-many-out validation experiments. The QSARs are based on 627–2023 chemicals and exhibited a wide applicability domain for FDA regulated organic chemicals for which they were designed. Experiments were also performed using the MC4PC multiple module prediction technology, and ROC statistics, and adjustments to the ratio of active to inactive (A/I ratio) chemicals in training data sets were made to optimize the predictive performance of QSAR models. Results revealed that an A/I ratio of ∼40% was optimal for MC4PC. We discuss specific recommendations for the application of the reprotox QSAR battery. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pollution
KW - Effect of chemicals on human reproduction
KW - Reproductive toxicology
KW - Developmental toxicology
KW - Computational toxicology
KW - Developmental toxicity
KW - Dysmorphogenesis
KW - MC4PC
KW - Predictive modeling
KW - Quantitative structure activity relationships (QSAR)
KW - Reproductive toxicity
KW - Reprotox
KW - Teratogenicity
KW - Weight of evidence
N1 - Accession Number: 23956781; Matthews, Edwin J. 1; Email Address: edwin.matthews@fda.hhs.gov; Kruhlak, Naomi L. 1; Daniel Benz, R. 1; Ivanov, Julian 2; Klopman, Gilles 2; Contrera, Joseph F. 1; Affiliations: 1: US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA; 2: Multicase Inc., 23811 Chagrin Blvd., Beachwood, OH 44122, USA; Issue Info: Mar2007, Vol. 47 Issue 2, p136; Thesaurus Term: Pollution; Subject Term: Effect of chemicals on human reproduction; Subject Term: Reproductive toxicology; Subject Term: Developmental toxicology; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Developmental toxicity; Author-Supplied Keyword: Dysmorphogenesis; Author-Supplied Keyword: MC4PC; Author-Supplied Keyword: Predictive modeling; Author-Supplied Keyword: Quantitative structure activity relationships (QSAR); Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Reprotox; Author-Supplied Keyword: Teratogenicity; Author-Supplied Keyword: Weight of evidence; Number of Pages: 20p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.10.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=23956781&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105963485
T1 - Effect of measurement on sex difference in stroke mortality.
AU - Sheikh K
AU - Bullock CM
AU - Sheikh, Kazim
AU - Bullock, Claudia M
Y1 - 2007/03//2007 Mar
N1 - Accession Number: 105963485. Language: English. Entry Date: 20080208. Revision Date: 20161126. Publication Type: journal article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 0235266.
KW - Reproduction
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Male
KW - Prospective Studies
KW - Human
SP - 1085
EP - 1087
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 38
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The 1994 to 1997 administrative data on 40 450 elderly Medicare beneficiaries and general population of 2 states were used to measure "case mortality" (deaths attributable to any cause among cases of acute stroke), "case fatality" (deaths caused by cerebrovascular diseases among cases of acute stroke), and "population mortality" (deaths caused by stroke in the elderly general population). Mortality was higher in men than in women according to all measures except population mortality caused by subarachnoid hemorrhage. There was no sex difference in 1-year case fatality. One-year all-cause mortality among cases of nonhemorrhagic stroke or all types of stroke was higher in men than in women. Similar sex differences were found in 4-year population mortality caused by nonhemorrhagic stroke or all types of stroke combined. The 3 measures differed with respect to sex difference in stroke mortality. How stroke is defined and how mortality is measured does affect sex difference.
SN - 0039-2499
AD - US Department of Health and Human Services, Centers for Medicare & Medicaid Services, Kansas City, MO 64106, USA
U2 - PMID: 17255545.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105963485&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, C. S.
AU - Ross, I. A.
AU - Sprando, R. L.
AU - Johnson, W. D.
AU - Sahu, S. C.
AU - Flynn, T. J.
AU - Wiesenfeld, P. L.
AU - Collins, T. F. X.
AU - O'Neill, R. K.
AU - Sapienza, P.
T1 - Distribution of androstenedione and its effects on total free fatty acids in pregnant rats.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2007/03//
VL - 23
IS - 2
M3 - Article
SP - 65
EP - 74
PB - Sage Publications, Ltd.
SN - 07482337
AB - Androstenedione, an anabolic steroid used to enhance athletic performance, was administered in corn oil by gastric intubation once daily in the morning to nonpregnant female rats at a dose of 5 or 60 mg/kg/day, beginning two weeks before mating and continuing through gestation day (GD) 19. On GD 20, the distribution of androstenedione and other steroid metabolites was investigated in the maternal plasma and target organs, including brain and liver. The concentration of estradiol in plasma approached a statistically significant increase after treatment as compared with the controls, whereas the levels of androstenedione, testosterone and progesterone were not significantly different from the controls. In the liver, the concentrations of androstenedione and estradiol only were increased in a dose-related manner. None of these steroids was detectable in the brain. Androstenedione treatment also produced changes in the level of selected free fatty acids (FFAs) in the maternal blood, brain, liver and fetal brain. The concentrations of palmitic acid (16:0) and stearic acid (18:0) in the plasma were not significantly different between the controls and treated rats. However, oleic acid (18:1), linoleic acid (18:2) and docosahexaenoic acid (DHA, 22:6) were 17.94 ± 2.06 μg/ml, 24.23 ± 2.42 μg/ml and 4.08 ± 0.53 μg/mI, respectively, in the controls, and none of these fatty acids was detectable in the treated plasma. On the other hand, palmitic, stearic, oleic, linoleic and DHA were present in both control and treated livers. Among the FFAs in liver, linoleic and DHA were increased 87% and 169%, respectively, over controls. Palmitic, stearic and oleic acids were not significantly affected by the 60 mg/kg treatment. These were present in both control maternal and fetal brains, whereas linoleic acid was found only in fetal brain control. DHA was present only in the control maternal brain (0.02 ± 0.02 μg/mg protein) and fetal brain (0.24 ± 0.15 μg/mg protein). The results indicated that androstenedione exhibits significantly different effects on the FFA composition among target organs during pregnancy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fatty acids
KW - Metabolites
KW - Pregnancy in animals
KW - Rats
KW - Androstenedione
KW - Anabolic steroids
KW - Linoleic acid
KW - Gastric intubation
KW - Sexual cycle
KW - androstenedione
KW - brain
KW - free fatty acids
KW - liver
KW - Oxidative stress
KW - pregnant rats
N1 - Accession Number: 33938053; Kim, C. S. 1; Email Address: chung.kim@fda.hhs.gov; Ross, I. A. 1; Sprando, R. L. 1; Johnson, W. D. 1; Sahu, S. C. 1; Flynn, T. J. 1; Wiesenfeld, P. L. 1; Collins, T. F. X. 1; O'Neill, R. K. 2; Sapienza, P. 1; Affiliations: 1: US FDA, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Laurel, MD 20708, USA; 2: US FDA, Center for Food Safety and Applied Nutrition, Office of the Scientific Analysis and Support, Laurel, MD 20708, USA; Issue Info: 2007, Vol. 23 Issue 2, p65; Thesaurus Term: Fatty acids; Thesaurus Term: Metabolites; Subject Term: Pregnancy in animals; Subject Term: Rats; Subject Term: Androstenedione; Subject Term: Anabolic steroids; Subject Term: Linoleic acid; Subject Term: Gastric intubation; Subject Term: Sexual cycle; Author-Supplied Keyword: androstenedione; Author-Supplied Keyword: brain; Author-Supplied Keyword: free fatty acids; Author-Supplied Keyword: liver; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: pregnant rats; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33938053&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tang, Shixing
AU - Ablan, Sherimay
AU - Dueck, Megan
AU - Ayala-López, Wilfredo
AU - Soto, Brenda
AU - Caplan, Margaret
AU - Nagashima, Kunio
AU - Hewlett, Indira K.
AU - Freed, Eric O.
AU - Levin, Judith G.
T1 - A second-site suppressor significantly improves the defective phenotype imposed by mutation of an aromatic residue in the N-terminal domain of the HIV-1 capsid protein
JO - Virology
JF - Virology
Y1 - 2007/03//
VL - 359
IS - 1
M3 - Article
SP - 105
EP - 115
SN - 00426822
AB - Abstract: The HIV-1 capsid (CA) protein plays an important role in virus assembly and infectivity. Previously, we showed that Ala substitutions in the N-terminal residues Trp23 and Phe40 cause a severely defective phenotype. In searching for mutations at these positions that result in a non-lethal phenotype, we identified one candidate, W23F. Mutant virions contained aberrant cores, but unlike W23A, also displayed some infectivity in a single-round replication assay and delayed replication kinetics in MT-4 cells. Following long-term passage in MT-4 cells, two second-site mutations were isolated. In particular, the W23F/V26I mutation partially restored the wild-type phenotype, including production of particles with conical cores and wild-type replication kinetics in MT-4 cells. A structural model is proposed to explain the suppressor phenotype. These findings describe a novel occurrence, namely suppression of a mutation in a hydrophobic residue that is critical for maintaining the structural integrity of CA and proper core assembly. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUPPRESSOR cells
KW - IMMUNOSUPPRESSION
KW - HIV (Viruses)
KW - PHENOTYPE
KW - Dominant-negative inhibition
KW - HIV-1 assembly
KW - HIV-1 capsid protein
KW - HIV-1 viral cores
KW - Reverse transcriptase
KW - Second-site suppressors
KW - Structural models
KW - Transmission electron microscopy
N1 - Accession Number: 23956375; Tang, Shixing 1,2 Ablan, Sherimay 3 Dueck, Megan 1 Ayala-López, Wilfredo 1 Soto, Brenda 1 Caplan, Margaret 1 Nagashima, Kunio 4 Hewlett, Indira K. 2 Freed, Eric O. 3 Levin, Judith G. 1; Email Address: levinju@mail.nih.gov; Affiliation: 1: Viral Gene Regulation Section, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 216, Bethesda, MD 20892-2780, USA 2: Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Virus–Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA 4: Image Analysis Laboratory, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA; Source Info: Mar2007, Vol. 359 Issue 1, p105; Subject Term: SUPPRESSOR cells; Subject Term: IMMUNOSUPPRESSION; Subject Term: HIV (Viruses); Subject Term: PHENOTYPE; Author-Supplied Keyword: Dominant-negative inhibition; Author-Supplied Keyword: HIV-1 assembly; Author-Supplied Keyword: HIV-1 capsid protein; Author-Supplied Keyword: HIV-1 viral cores; Author-Supplied Keyword: Reverse transcriptase; Author-Supplied Keyword: Second-site suppressors; Author-Supplied Keyword: Structural models; Author-Supplied Keyword: Transmission electron microscopy; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.virol.2006.09.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23956375&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-11077-005
AN - 2007-11077-005
AU - Raneri, Leslie G.
AU - Wiemann, Constance M.
T1 - Social ecological predictors of repeat adolescent pregnancy.
JF - Perspectives on Sexual and Reproductive Health
JO - Perspectives on Sexual and Reproductive Health
JA - Perspect Sex Reprod Health
Y1 - 2007/03//
VL - 39
IS - 1
SP - 39
EP - 47
CY - United Kingdom
PB - Blackwell Publishing
SN - 1538-6341
SN - 1931-2393
AD - Raneri, Leslie G.
N1 - Accession Number: 2007-11077-005. PMID: 17355380 Partial author list: First Author & Affiliation: Raneri, Leslie G.; Office of Adolescent Pregnancy Programs, Office of Population Affairs, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071203. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual meeting of the Society for Adolescent Medicine, Mar, 2006, Boston, MA, US. Conference Note: These findings were presented at the aforementioned conference. Major Descriptor: Adolescent Pregnancy; Intervention; Prevention; Risk Factors. Minor Descriptor: Adolescent Mothers; Family. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Followup Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2007.
AB - Context: Women with multiple pregnancies in adolescence may experience medical, psychological and social complications. Improved understanding of the individual-, dyad-, family-, peer/community- and social system-level risk factors for repeat pregnancy may lead to the development of more effective prevention strategies for adolescent mothers in a variety of settings. Methods: Between 1993 and 1996, white, black and Mexican American adolescent mothers at a labor and delivery unit in Texas were interviewed after delivery and completed written surveys prospectively for up to 48 months. Logistic regression analyses were used to determine predictors of repeat pregnancy within 24 months, using social ecological theory as a guide. Results: Forty-two percent of adolescent mothers experienced a repeat pregnancy within 24 months; 73% of these delivered a second child. Individual-level predictors were planning to have an other baby with in five years (odds ratio, 1.6) and not using long-acting contraceptives within three months of delivery (2.4). Dyad-level predictors were not being in a relationship with the father of the first child three months after delivery (2.0), being more than three years younger than the first child's father (1.6) and experiencing intimate partner violence within three months after delivery (1.9). Peer/community-level predictors were not being in school three months postpartum (1.8) and having many friends who were adolescent parents (1.5). Conclusion: Adolescent mothers are at high risk for a rapid subsequent pregnancy. Interventions that address the complex and multifaceted aspects of the lives of adolescent mothers are needed to prevent repeat pregnancy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - social ecological predictors
KW - repeat adolescent pregnancy
KW - social complications
KW - interventions
KW - risk factors
KW - prevention strategies
KW - 2007
KW - Adolescent Pregnancy
KW - Intervention
KW - Prevention
KW - Risk Factors
KW - Adolescent Mothers
KW - Family
KW - 2007
U1 - Sponsor: National Institute on Drug Abuse. Grant: DA09636; DA08404. Recipients: No recipient indicated
U1 - Sponsor: Hogg Foundation for Mental Health. Grant: 3777. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Grant: T71MC00011. Recipients: No recipient indicated
DO - 10.1363/3903907
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11077-005&site=ehost-live&scope=site
UR - Leslie.Raneri@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17827-002
AN - 2007-17827-002
AU - Cox, Shanna
AU - Johnson, Chris H.
AU - Meikle, Susan
AU - Jamieson, Denise J.
AU - Posner, Samuel F.
T1 - Trends in rates of hospitalization with a diagnosis of substance abuse among reproductive-age women, 1998 to 2003.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2007/03//Mar-Apr, 2007
VL - 17
IS - 2
SP - 75
EP - 83
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Cox, Shanna, Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Highway MS K-20, Atlanta, GA, US, 30341
N1 - Accession Number: 2007-17827-002. PMID: 17403464 Partial author list: First Author & Affiliation: Cox, Shanna; Center for Disease Control and Prevention, Division of Reproductive Health, Atlanta, GA, US. Release Date: 20080204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diagnosis; Drug Abuse; Hospitalization; Human Females. Minor Descriptor: Sexual Reproduction. Classification: Substance Abuse & Addiction (3233); Drug & Alcohol Rehabilitation (3383). Population: Human (10); Female (40); Inpatient (50). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Other Appended. References Available: Y. Page Count: 9. Issue Publication Date: Mar-Apr, 2007.
AB - Objective: To describe trends in hospitalizations with a diagnosis of substance abuse among reproductive-age women from 1998-2003. Methods: Data were obtained from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Hospitalizations with a diagnosis of substance abuse were categorized into subgroups by age, primary expected payer, substance-specific diagnoses, concomitance, and hospital location. Trends in hospitalization rates per 100,000 women aged 15-44 were tested using a weighted least-squares method. Results: From 1998-2003, there was no change in the overall rate of hospitalization with a diagnosis of substance abuse among women aged 15-44. Alcohol abuse was the most common substance-specific diagnosis. The rate of hospitalization with a diagnosis of cocaine abuse decreased 22%; for a diagnosis of cannabis abuse, the rate increased 35%. The rate of hospitalization with a diagnosis of amphetamine abuse doubled from 1998-2003. Among women aged 15-24, the rate of hospitalization with a diagnosis of substance abuse increased 23%. Conclusion: Although we did not observe a change in the overall rate of substance-abuse hospitalization among reproductive-age women, there were dramatic changes in the rate of substance-specific diagnoses. These data may be used to quantify emerging trends in substance abuse and promote the use of hospital-based interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospitalization
KW - diagnosis
KW - substance abuse
KW - reproductive age women
KW - 2007
KW - Diagnosis
KW - Drug Abuse
KW - Hospitalization
KW - Human Females
KW - Sexual Reproduction
KW - 2007
U1 - Sponsor: US Department of Energy/Centers for Disease Control and Prevention. Other Details: Research Participation Program at the Centers for Disease Control and Prevention (CDC), Division of Reproductive Health that was administered by the Oak Ridge Institute for Science and Education. Recipients: No recipient indicated
DO - 10.1016/j.whi.2007.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17827-002&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1574-585X
UR -
UR - cio8@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06599-001
AN - 2007-06599-001
AU - Morata, Thais C.
ED - Morata, Thais C.
T1 - Young people: Their noise and music exposures and the risk of hearing loss.
T3 - Focus on the effects of noise on hearing
JF - International Journal of Audiology
JO - International Journal of Audiology
JA - Int J Audiol
Y1 - 2007/03//
VL - 46
IS - 3
SP - 111
EP - 112
CY - US
PB - Informa Healthcare
SN - 1499-2027
SN - 1708-8186
AD - Morata, Thais C., Hearing Loss Prevention Team, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-06599-001. PMID: 17365063 Partial author list: First Author & Affiliation: Morata, Thais C.; Hearing Loss Prevention Team, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Other Publishers: Taylor & Francis. Release Date: 20070528. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Auditory Thresholds; Epidemiology; Hearing Disorders; Music; Noise Effects. Classification: Vision & Hearing & Sensory Disorders (3299). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2007.
AB - This editorial speaks of music exposure as the most studied source of excessive sound exposure to children and youths. Caused by things such as social and economic changes, new personal music devices, and ever increasing intensity levels during concerts and at nightclubs, the term music-induced hearing loss is now used for a condition akin to noise-induced hearing loss. This editorial also introduces current research in this area, including increased risk with increasing exposures, hearing thresholds among several occupations, prevalence of hearing loss in baseline audiograms, a conference on noise-induced hearing loss, and how long term school-based programs can effectively increase the use of hearing protection among students. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - noise exposure
KW - music exposure
KW - hearing loss risk
KW - music-induced hearing loss
KW - hearing thresholds
KW - prevalence
KW - 2007
KW - Auditory Thresholds
KW - Epidemiology
KW - Hearing Disorders
KW - Music
KW - Noise Effects
KW - 2007
DO - 10.1080/14992020601103079
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06599-001&site=ehost-live&scope=site
UR - tmorata@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11740-009
AN - 2008-11740-009
AU - Smith, Derek R.
AU - Leggat, Peter A.
T1 - An international review of tobacco smoking research in the nursing profession, 1976-2006.
JF - Journal of Research in Nursing
JO - Journal of Research in Nursing
JA - J Res Nurs
Y1 - 2007/03//
VL - 12
IS - 2
SP - 165
EP - 181
CY - US
PB - Sage Publications
SN - 1744-9871
SN - 1744-988X
AD - Smith, Derek R.
N1 - Accession Number: 2008-11740-009. Other Journal Title: NT Research. Partial author list: First Author & Affiliation: Smith, Derek R.; National Institute of Occupational Safety and Health, Kawasaki, Japan. Release Date: 20080915. Correction Date: 20121015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health Care Services; Nurses; Quality of Care; Tobacco Smoking. Minor Descriptor: Epidemiology; Nursing. Classification: Drug & Alcohol Usage (Legal) (2990); Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 17. Issue Publication Date: Mar, 2007.
AB - Tobacco smoking represents a contentious issue in the nursing profession, and one that has now become an important topic in nursing research. Despite this fact, the epidemiological quality of research varies widely, and it has been difficult to accurately determine the true incidence of smoking among nurses. Given these inconsistencies, we conducted a state-of-the-art review to identify international trends in tobacco usage among nurses, to ascertain how the epidemiological quality of research has improved over the past 30 years, and also to elucidate the directions in which nursing research has evolved. A total of 73 English-language studies that met the inclusion criteria were located and analysed. Overall, our review suggests that, while tobacco smoking among nurses appears to be decreasing in many countries during recent years, the international trend is far from uniform, and some developed nations still report high smoking rates among their nursing staff. From a methodological perspective, the relative epidemiological quality of smoking research has also fluctuated over time, making it difficult to compare the results of one study to the next. Despite these caveats, tobacco smoking remains a key topic in nursing research, as well as a critically important occupational-health issue for the entire nursing profession. In order to make the next generation of tobacco research data as comparable as possible, future scholars should consider devising and implementing a standardised format for conducting international tobacco smoking research within the nursing profession. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tobacco smoking research
KW - nursing profession
KW - epidemiology
KW - quality of care
KW - health care services
KW - nurses
KW - 2007
KW - Experimentation
KW - Health Care Services
KW - Nurses
KW - Quality of Care
KW - Tobacco Smoking
KW - Epidemiology
KW - Nursing
KW - 2007
DO - 10.1177/1744987106074875
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11740-009&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-8202-2523
UR - smith@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-05965-001
AN - 2007-05965-001
AU - Cunningham, Chinazo O.
AU - Sohler, Nancy L.
AU - Wong, Mitchell D.
AU - Relf, Michael
AU - Cunningham, William E.
AU - Drainoni, Mari-Lynn
AU - Bradford, Judith
AU - Pounds, Moses B.
AU - Cabral, Howard D.
T1 - Utilization of health care services in hard-to-reach marginalized HIV-infected individuals.
JF - AIDS Patient Care and STDs
JO - AIDS Patient Care and STDs
JA - AIDS Patient Care STDS
Y1 - 2007/03//
VL - 21
IS - 3
SP - 177
EP - 186
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
SN - 1557-7449
AD - Cunningham, Chinazo O., Montefiore Medical Center, 111 E. 210th Street, Bronx, NY, US, 10467
N1 - Accession Number: 2007-05965-001. PMID: 17428185 Partial author list: First Author & Affiliation: Cunningham, Chinazo O.; Montefiore Medical Center, Bronx, NY, US. Release Date: 20080107. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cunningham, Chinazo O. Major Descriptor: Health Care Utilization; HIV; Infectious Disorders; Mental Health Services. Classification: Immunological Disorders (3291); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2007.
AB - To benefit from HIV treatment advances individuals must utilize ambulatory primary care services. Few studies focus on marginalized populations, which tend to have poor health care utilization patterns. This study examined factors associated with health care utilization in hard-to-reach marginalized HIV-infected individuals. As part of a multisite initiative evaluating outreach programs that target underserved HIV-infected individuals, 610 participants were interviewed about their HIV disease, health services utilization, substance use, mental health, and case management. Primary outcomes included ambulatory, emergency department, and inpatient visits. Generalized estimating equations were used in logistic regression analyses. On regression analyses ambulatory visits were associated with having insurance (adjusted odds ratio [AOR] = 2.46), mental health medications (AOR = 7.46), and case management (AOR = 4.81). Emergency department visits were associated with having insurance (AOR = 1.74), homelessness (AOR = 2.23), poor health status (AOR = 2.02), length of HIV infection (AOR = 2.02), mental health care (AOR = 1.47), mental health medications (AOR = 1.59), and heavy alcohol intake (AOR = 1.46). Hospitalizations were associated with high school education (AOR = 1.57), having insurance (AOR = 10.45), homelessness (AOR = 2.18), poor health status (AOR = 2.64), length of HIV infection (AOR = 2.03), and mental health medications (AOR = 1.87). In hard-to-reach marginalized HIV-infected individuals, having insurance, case management and mental health care were associated with increased ambulatory visits. These findings support HIV multidisciplinary care with marginalized populations. Understanding factors associated with health care utilization is essential for outreach programs to facilitate engagement in HIV care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care utilization
KW - health care services
KW - HIV-infected individuals
KW - 2007
KW - Health Care Utilization
KW - HIV
KW - Infectious Disorders
KW - Mental Health Services
KW - 2007
U1 - Sponsor: Health Resources and Services Administration, National Significance, HIV/AIDS Bureau. Grant: 2H97 HA 00247-03. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: AI-51519. Recipients: No recipient indicated
U1 - Sponsor: Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program. Recipients: Cunningham, Chinazo O.
DO - 10.1089/apc.2006.103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-05965-001&site=ehost-live&scope=site
UR - ORCID: 0000-0001-7214-8037
UR - ORCID: 0000-0002-4800-8410
UR -
UR - ccunning@montefiore.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-04262-005
AN - 2007-04262-005
AU - Ferguson, Sherry A.
AU - Berry, Kimberly J.
T1 - Oral Accutane® (13-cis-retinoic acid) has no effects on spatial learning and memory in male and female Sprague-Dawley rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2007/03//
VL - 29
IS - 2
SP - 219
EP - 227
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Ferguson, Sherry A., HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2007-04262-005. PMID: 17161936 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20070611. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Berry, Kimberly J. Major Descriptor: Animal Learning; Drug Dosages; Spatial Learning; Spatial Memory. Minor Descriptor: Acids; Rats. Classification: Psychopharmacology (2580); Learning & Motivation (2420). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2007.
AB - Descriptions of psychiatric effects with Accutane® (13-cis-retinoic acid (13-cis-RA)) use prompted a series of studies in a rodent model to ascertain its cognitive effects. Previously, we reported no effects on measures of anhedonia and depression in rats treated with 7.5, 22.5, or 30 mg/kg 13-cis-RA [S.A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459 [16]; S.A. Ferguson, F.J., Cisneros, J.P. Hanig, K.J. Berry, Chronic oral treatment with Accutane (13-cis-retinoic acid) does not increase measures of anhedonia or depression in male and female Sprague-Dawley rats, (in preparation) [19]]. Here, we assessed spatial learning and memory in male and female Sprague-Dawley rats gavaged daily beginning on postnatal day (PND) 59 with vehicle control (soybean oil), 7.5 or 30 mg/kg of 13-cis-RA. We have reported that 7.5 mg/kg produces serum levels of 13-cis-RA comparable to those of humans prescribed Accutane® [S.A. Ferguson, P.H. Siitonen, F.J. Cisneros, B. Gough, J.F. Young, Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all- trans-retinoic acid in male and female adult rats, Basic Clin. Pharmacol. Toxicol. 98 (2006) 582-587 [18]]. Three behavioral tasks assessed spatial learning and memory after chronic 13-cis-RA treatment: the escape-reinforced Morris water maze (PNDs 111-115), the food-reinforced 8-arm radial maze (PNDs 132-136), and the water-reinforced NCTR complex maze (PNDs 153-157). Behaviors were measured after a minimum of 52 and maximum of 94 days of 13-cis-RA treatment. 13-cis-RA treatment had no effects on performance of the 8-arm radial maze or the NCTR complex maze. Treatment effects on Morris water maze performance were negligible and neither dose-related nor consistent. Performances of the control group were quite similar to those previously described in this laboratory. These results indicate that chronic 13-cis-RA treatment in male and female rats has few effects on measures of spatial learning and memory. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oral accutane
KW - spatial learning
KW - spatial memory
KW - rats
KW - acids
KW - 2007
KW - Animal Learning
KW - Drug Dosages
KW - Spatial Learning
KW - Spatial Memory
KW - Acids
KW - Rats
KW - 2007
U1 - Sponsor: US Department of Energy/US Food and Drug Administration, Oak Ridge Institute for Science and Education. Recipients: Berry, Kimberly J.
DO - 10.1016/j.ntt.2006.10.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-04262-005&site=ehost-live&scope=site
UR - Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02375-008
AN - 2007-02375-008
AU - Ockene, Judith K.
AU - Edgerton, Elizabeth A.
AU - Teutsch, Steven M.
AU - Marion, Lucy N.
AU - Miller, Therese
AU - Genevro, Janice L.
AU - Loveland-Cherry, Carol J.
AU - Fielding, Jonathan E.
AU - Briss, Peter A.
T1 - Integrating Evidence-Based Clinical and Community Strategies to Improve Health.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2007/03//
VL - 32
IS - 3
SP - 244
EP - 252
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Ockene, Judith K., Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2007-02375-008. PMID: 17296474 Partial author list: First Author & Affiliation: Ockene, Judith K.; Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20070521. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Practice; Communities; Evidence Based Practice; Health; Health Promotion. Minor Descriptor: Program Development; Strategies. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2007.
AB - Multiple and diverse preventive strategies in clinical and community settings are necessary to improve health. This paper (1) introduces evidence-based recommendations from the U.S. Preventive Services Task Force sponsored by the Agency for Healthcare Research and Quality and the Community Task Force sponsored by the Centers for Disease Control and Prevention, (2) examines, using a social-ecologic model, the evidence-based strategies for use in clinical and community settings to address preventable health-related problems such as tobacco use and obesity, and (3) advocates for prioritization and integration of clinical and community preventive strategies in the planning of programs and policy development, calling for additional research to develop the strategies and systems needed to integrate them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evidence-based clinical
KW - community strategies
KW - health
KW - program development
KW - 2007
KW - Clinical Practice
KW - Communities
KW - Evidence Based Practice
KW - Health
KW - Health Promotion
KW - Program Development
KW - Strategies
KW - 2007
DO - 10.1016/j.amepre.2006.11.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02375-008&site=ehost-live&scope=site
UR - Judith.Ockene@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02368-003
AN - 2007-02368-003
AU - McDowell, T. W.
AU - Wiker, S. F.
AU - Dong, R. G.
AU - Welcome, D. E.
T1 - Effects of vibration on grip and push force-recall performance.
JF - International Journal of Industrial Ergonomics
JO - International Journal of Industrial Ergonomics
JA - Int J Ind Ergon
Y1 - 2007/03//
VL - 37
IS - 3
SP - 257
EP - 266
CY - Netherlands
PB - Elsevier Science
SN - 0169-8141
AD - McDowell, T. W., Health Effects Laboratory Division, Engineering and Control Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, M/S 2027, Morgantown, WV, US, 26505
N1 - Accession Number: 2007-02368-003. Partial author list: First Author & Affiliation: McDowell, T. W.; Health Effects Laboratory Division, Engineering and Control Technology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, US. Release Date: 20070521. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Stimulus Frequency; Vibration. Minor Descriptor: Human Sex Differences. Classification: Motor Processes (2330). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2007.
AB - Comprehensive assessments of health risks associated with the operation of vibratory tools should include evaluations of hand-tool coupling forces. The use of hand-force instrumentation in field applications can be difficult and expensive. A previous study (McDowell, T.W., Wiker, S.F., Dong, R.G., Welcome, D.E., Schopper, A.W., 2006. Evaluation of psychometric estimates of vibratory hand-tool grip and push forces. International Journal of Industrial Ergonomics 36(2), 119-128.) examined various combinations of handle vibration frequencies and grip and push force levels upon one's ability to recall those forces using psychophysical methods. The results of that study were promising. The present study is a follow-up experiment that further investigated the potential for using psychophysical force-recall methods to estimate grip and push forces when operating powered hand tools. In this experiment, 20 subjects (10 male, 10 female) grasped and pushed an instrumented handle for 45 s at one of three force levels while it vibrated sinusoidally at one of four frequencies (16, 31.5, 63, or 125 Hz) or with no vibration. Unlike the first study, two levels of vibration magnitude were examined along with gender differences. This study further clarifies relationships between vibration exposure characteristics and their effects on grip and push force-recall performance. Vibration exposure conditions and other influential factors can be accounted for in enhanced force-recall methodologies that can be incorporated into a variety of workplace exposure assessment applications. Relevance to industry: Workers who are repeatedly exposed to intense hand-transmitted vibration are at risk of developing health problems. To better assess these health risks, hand-tool coupling forces should be evaluated. A refined psychophysical force-recall technique may be a practical alternative to expensive or fragile instrumentation. Before such a method is proposed for laboratory or field applications, an understanding of vibration effects upon force-recall performance must first be explored. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vibration
KW - grip
KW - push force-recall performance
KW - gender differences
KW - 2007
KW - Stimulus Frequency
KW - Vibration
KW - Human Sex Differences
KW - 2007
DO - 10.1016/j.ergon.2006.10.024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02368-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-2416-2210
UR - TMcDowell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-02933-006
AN - 2007-02933-006
AU - Jensen, Peter S.
AU - Youngstrom, Eric A.
AU - Steiner, Hans
AU - Findling, Robert L.
AU - Meyer, Roger E.
AU - Malone, Richard P.
AU - Carlson, Gabrielle A.
AU - Coccaro, Emil F.
AU - Aman, Michael G.
AU - Blair, James
AU - Dougherty, Donald
AU - Ferris, Craig
AU - Flynn, Laurie
AU - Green, Evelyn
AU - Hoagwood, Kimberly
AU - Hutchinson, Janice
AU - Laughren, Tom
AU - Leve, Leslie D.
AU - Novins, Douglas K.
AU - Vitiello, Benedetto
T1 - Consensus Report on Impulsive Aggression as a Symptom Across Diagnostic Categories in Child Psychiatry: Implications for Medication Studies.
JF - Journal of the American Academy of Child & Adolescent Psychiatry
JO - Journal of the American Academy of Child & Adolescent Psychiatry
JA - J Am Acad Child Adolesc Psychiatry
Y1 - 2007/03//
VL - 46
IS - 3
SP - 309
EP - 322
CY - US
PB - Lippincott Williams & Wilkins
SN - 0890-8567
SN - 1527-5418
AD - Jensen, Peter S., Center for the Advancement of Children's Mental Health, Columbia University, NYSPI, 1051 Riverside Drive, Unit #78, New York, NY, US, 10032
N1 - Accession Number: 2007-02933-006. PMID: 17314717 Other Journal Title: Journal of the American Academy of Child Psychiatry. Partial author list: First Author & Affiliation: Jensen, Peter S.; Columbia University, New York, NY, US. Other Publishers: Elsevier Science. Release Date: 20070618. Correction Date: 20110207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Aggressive Behavior; Child Psychiatry; Impulsiveness; Methodology; Scientific Communication. Minor Descriptor: Mental Health. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Mar, 2007.
AB - Objective: To determine whether impulsive aggression (IA) is a meaningful clinical construct and to ascertain whether it is sufficiently similar across diagnostic categories, such that parallel studies across disorders might constitute appropriate evidence for pursuing indications. If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed? Method: Experts from key stakeholder communities, including academic clinicians, researchers, practicing clinicians, U.S. Food and Drug Administration, National Institute of Mental Health, industry sponsors, and patient and family advocates, met for a 2-day consensus conference on November 4 and 5, 2004. After evaluating summary presentations on current research evidence, participants were assigned to three workgroups, examined core issues, and generated consensus guidelines in their areas. Workgroup recommendations were discussed by the whole group to reach consensus, and then further iterated and condensed into this report postconference by the authors. Results: Conference participants agreed that IA is a substantial public health and clinical concern, constitutes a key therapeutic target across multiple disorders, and can be measured with sufficient precision that pharmacological studies are warranted. Additional areas of consensus concerned types of measures, optimal study designs, and ethical imperatives. Conclusion: Derived from scientific evidence and clinical experience, these consensus-driven recommendations can guide the design of future studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consensus report
KW - impulsive aggression
KW - diagnostic categories
KW - child psychiatry
KW - methodology
KW - 2007
KW - Aggressive Behavior
KW - Child Psychiatry
KW - Impulsiveness
KW - Methodology
KW - Scientific Communication
KW - Mental Health
KW - 2007
U1 - Sponsor: Annie E. Casey Foundation. Recipients: No recipient indicated
U1 - Sponsor: Bristol-Myers Squibb. Recipients: No recipient indicated
U1 - Sponsor: Forest Research Institute. Recipients: No recipient indicated
U1 - Sponsor: Jazz Pharmaceuticals. Recipients: No recipient indicated
U1 - Sponsor: Otsuka Pharmaceuticals. Recipients: No recipient indicated
U1 - Sponsor: Janssen. Recipients: No recipient indicated
U1 - Sponsor: Eli Lilly. Recipients: No recipient indicated
U1 - Sponsor: Pfizer Laboratories. Recipients: No recipient indicated
U1 - Sponsor: Sanofi Synthebtbo. Recipients: No recipient indicated
DO - 10.1097/chi.0b013e31802f1454
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-02933-006&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3061-4524
UR -
UR - ORCID: 0000-0003-2387-0650
UR - pj131@columbia.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-04511-002
AN - 2007-04511-002
AU - Spector, William
AU - Shaffer, Thomas
AU - Potter, D. E. B.
AU - Correa-de-Araujo, Rosaly
AU - Limcangco, M. Rhona
T1 - Risk Factors Associated with the Occurrence of Fractures in U.S. Nursing Homes: Resident and Facility Characteristics and Prescription Medications.
JF - Journal of the American Geriatrics Society
JO - Journal of the American Geriatrics Society
JA - J Am Geriatr Soc
Y1 - 2007/03//
VL - 55
IS - 3
SP - 327
EP - 333
CY - United Kingdom
PB - Blackwell Publishing
SN - 0002-8614
SN - 1532-5415
AD - Spector, William, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-04511-002. PMID: 17341233 Partial author list: First Author & Affiliation: Spector, William; Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Hospital Environment; Injuries; Prescription Drugs; Risk Factors. Minor Descriptor: Medical Records; Nurses; Nursing; Nursing Homes. Classification: Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Mar, 2007.
AB - Objectives: To determine whether resident and facility characteristics and prescription medications influence the occurrence of fractures in nursing homes (NHs). Design: Panel study with 1-year follow-up. Setting: A nationally representative sample of NHs from the Medical Expenditure Panel Survey (MEPS). Participants: Residents aged 65 and older who were in sample NHs on January 1, 1996. Measurements: Health status measures were collected from facility records and abstracted using a computer-assisted personal interview instrument. Fracture and drug data were updated every 4 months to provide a full year of information. Drug data were obtained from monthly medication administration records. The occurrences of fractures were obtained from medical records. Administered medications were classified using the Department of Veterans Affairs medication classification system. Facility characteristics were based on MEPS survey data collected from NH sources. Results: In 1996, 6% of residents in a NH at the beginning of the year experienced a fracture during their NH stay(s). Resident risk factors included aged 85 and older, admitted from the community, exhibited agitated behaviors, and used both wheelchair and cane or walker. Use of anticonvulsants, antidepressants, opioid analgesics, iron supplements, bisphosphonates, thiazides, and laxatives were associated with fractures. A high certified nurse aide ratio was negatively associated with fractures. Conclusion: The findings indicate that fractures are associated with resident and facility characteristics and prescribing practices. It reaffirms the importance of medication review with special attention on opioid analgesics, antidepressants, and anticonvulsants to reduce the risk of fractures. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - resident characteristics
KW - facility characteristics
KW - prescription medications
KW - fractures occurrence
KW - nursing homes
KW - risk factors
KW - 2007
KW - Client Characteristics
KW - Hospital Environment
KW - Injuries
KW - Prescription Drugs
KW - Risk Factors
KW - Medical Records
KW - Nurses
KW - Nursing
KW - Nursing Homes
KW - 2007
DO - 10.1111/j.1532-5415.2007.01081.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-04511-002&site=ehost-live&scope=site
UR - William.Spector@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-03985-005
AN - 2007-03985-005
AU - Waters, Thomas
AU - Rauche, Christin
AU - Genaidy, Ash
AU - Rashed, Tarek
T1 - A new framework for evaluating potential risk of back disorders due to whole body vibration and repeated mechanical shock.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2007/03//
VL - 50
IS - 3
SP - 379
EP - 395
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Waters, Thomas, National Institute for Occupational Safety and Health, ML C24, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-03985-005. PMID: 17536775 Partial author list: First Author & Affiliation: Waters, Thomas; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20070723. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Back Pain; Musculoskeletal System; Shock; Vibration; Working Conditions. Minor Descriptor: Epidemiology; Health. Classification: Working Conditions & Industrial Safety (3670); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Mar, 2007.
AB - A number of studies have examined the potential relationship between exposure to occupational vibration and low back pain associated with operation of vehicles. Only a handful of studies, however, have attempted to differentiate between the relative contributions of the steady state and transient mechanical shock components (the latter also being known as 'jarring and jolting', 'high acceleration event', 'multiple shocks' and 'impact') of the vibration exposure. The primary objective of this paper is to present a review of current studies that examine mechanical shock, present a case for the importance of evaluating both steady state and mechanical shock components and propose a new framework for evaluating the health effects due to occupational vibration exposure. A computerized bibliographical search of several databases was performed with special reference to the health effects of mechanical shock in relation to lower back disorders. Based on the analysis, eight experimental studies and nine epidemiological studies with relevance to exposure to 'mechanical shock' were identified. These studies suggested that rough vehicle rides are prevalent and that repeated exposure to mechanical shock may increase the risk of lower back pain. There is an urgent need for assessing the health effects of mechanical shocks in epidemiological studies. In particular, the new ISO 2631-5: International Organization for Standardization 2004 standard for shock exposure assessment should be evaluated with regard to musculoskeletal health effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - potential risk evaluation
KW - back disorders
KW - body vibration
KW - repeated mechanical shock
KW - musculoskeletal health effects
KW - occupational vibration
KW - 2007
KW - Back Pain
KW - Musculoskeletal System
KW - Shock
KW - Vibration
KW - Working Conditions
KW - Epidemiology
KW - Health
KW - 2007
DO - 10.1080/00140130601089978
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-03985-005&site=ehost-live&scope=site
UR - trw1@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07387-001
AN - 2007-07387-001
AU - Ryan, Doreen Major
AU - Bonnett, Doreen M.
AU - Gass, Callie B.
T1 - 'Sobering thoughts: Town hall meetings on fetal alcohol spectrum disorders': Erratum.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/03//
VL - 97
IS - 3
SP - 393
EP - 393
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
N1 - Accession Number: 2007-07387-001. Partial author list: First Author & Affiliation: Ryan, Doreen Major; Fetal Alcohol Spectrum Disorders (FASD), Center for Excellence, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, US. Release Date: 20071119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Fetal Alcohol Syndrome; Health Education. Minor Descriptor: Developmental Disabilities; Prenatal Exposure; Towns. Classification: Promotion & Maintenance of Health & Wellness (3365); Substance Abuse & Addiction (3233). Population: Human (10). Page Count: 1. Issue Publication Date: Mar, 2007.
AB - Reports an error in 'Sobering thoughts: Town hall meetings on fetal alcohol spectrum disorders' by Doreen Major Ryan, Doreen M. Bonnett and Callie B. Gass (American Journal of Public Health, 2006[Dec], Vol 96[12], 2098-2101). An image title and source were improperly reported. On page 2100, the image title is Tahitian Flower. On page 2100, the image source line is: Source. http://www.sereneartistry.com. doi:10.2105/AJPH.2005.062729e. (The following abstract of the original article appeared in record [rid]2007-06742-001[/rid]). Prenatal exposure to alcohol is one of the leading causes of preventable birth defects and developmental disabilities. During the past 30 years, fetal alcohol spectrum disorders (FASD), including fetal alcohol syndrome, have gradually begun to attract attention. However, awareness and understanding of the disorders remain low, and people who are affected are seriously underserved. The FASD Center for Excellence held a series of town hall meetings in 2002 and 2003 to gauge the issues surrounding FASD nationwide. On the basis of its findings, the center proposed a series of recommendations to begin to remedy some of the deficiencies that were identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal alcohol spectrum disorders
KW - prenatal exposure
KW - town hall meetings
KW - 2007
KW - Fetal Alcohol Syndrome
KW - Health Education
KW - Developmental Disabilities
KW - Prenatal Exposure
KW - Towns
KW - 2007
DO - 10.2105/AJPH.2005.082818e
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07387-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07387-004
AN - 2007-07387-004
AU - Schulte, Paul A.
AU - Wagner, Gregory R.
AU - Ostry, Aleck
AU - Blanciforti, Laura A.
AU - Cutlip, Robert G.
AU - Krajnak, Kristine M.
AU - Luster, Michael
AU - Munson, Albert E.
AU - O'Callaghan, James P.
AU - Parks, Christine G.
AU - Simeonova, Petia P.
AU - Miller, Diane B.
T1 - Work, obesity, and occupational safety and health.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/03//
VL - 97
IS - 3
SP - 428
EP - 436
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Schulte, Paul A., Education and Information Division, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-07387-004. PMID: 17267711 Partial author list: First Author & Affiliation: Schulte, Paul A.; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, US. Release Date: 20071119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Obesity; Occupational Safety; Work Related Illnesses; Working Conditions. Minor Descriptor: Overweight; Risk Factors. Classification: Working Conditions & Industrial Safety (3670); Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: US. Methodology: Literature Review. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2007.
AB - There is increasing evidence that obesity and overweight may be related, in part, to adverse work conditions. In particular, the risk of obesity may increase in high-demand, low-control work environments, and for those who work long hours. In addition, obesity may modify the risk for vibration-induced injury and certain occupational musculoskeletal disorders. We hypothesized that obesity may also be a co-risk factor for the development of occupational asthma and cardiovascular disease that and it may modify the worker's response to occupational stress, immune response to chemical exposures, and risk of disease from occupational neurotoxins. We developed 5 conceptual models of the interrelationship of work, obesity, and occupational safety and health and highlighted the ethical, legal, and social issues related to fuller consideration of obesity's role in occupational health and safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work environments
KW - obesity
KW - occupational safety
KW - health
KW - overweight
KW - work conditions
KW - risk factors
KW - 2007
KW - Health
KW - Obesity
KW - Occupational Safety
KW - Work Related Illnesses
KW - Working Conditions
KW - Overweight
KW - Risk Factors
KW - 2007
DO - 10.2105/AJPH.2006.086900
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07387-004&site=ehost-live&scope=site
UR - pas4@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2006-21840-005
AN - 2006-21840-005
AU - Liu, Aiyi
AU - Wu, Chengqing
AU - Yu, Kai F.
AU - Yuan, Weishi
T1 - Completeness and unbiased estimation of mean vector in the multivariate group sequential case.
JF - Journal of Multivariate Analysis
JO - Journal of Multivariate Analysis
JA - J Multivar Anal
Y1 - 2007/03//
VL - 98
IS - 3
SP - 505
EP - 516
CY - Netherlands
PB - Elsevier Science
SN - 0047-259X
AD - Liu, Aiyi, Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Department of Health and Human Services, 6100 Executive Blvd., Rockville, MD, US, 20852
N1 - Accession Number: 2006-21840-005. Partial author list: First Author & Affiliation: Liu, Aiyi; Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Department of Health and Human Services, Rockville, MD, US. Release Date: 20070430. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Maximum Likelihood; Multivariate Analysis; Statistical Estimation; Statistics; Test Norms. Classification: Statistics & Mathematics (2240). Population: Human (10). Methodology: Mathematical Model. References Available: Y. Page Count: 12. Issue Publication Date: Mar, 2007.
AB - We consider estimation after a group sequential test about a multivariate normal mean, such as a χ² test or a sequential version of the Bonferroni procedure. We derive the density function of the sufficient statistics and show that the sample mean remains to be the maximum likelihood estimator but is no longer unbiased. We propose an alternative Rao-Blackwell type unbiased estimator. We show that the family of distributions of the sufficient statistic is not complete, and there exist infinitely many unbiased estimators of the mean vector and none has uniformly minimum variance. However, when restricted to truncation-adaptable statistics, completeness holds and the Rao-Blackwell estimator has uniformly minimum variance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - unbiased estimation
KW - mean vector
KW - multivariate analysis
KW - group sequential test
KW - maximum likelihood estimator
KW - statistics
KW - 2007
KW - Maximum Likelihood
KW - Multivariate Analysis
KW - Statistical Estimation
KW - Statistics
KW - Test Norms
KW - 2007
DO - 10.1016/j.jmva.2006.01.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2006-21840-005&site=ehost-live&scope=site
UR - liua@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 106283769
T1 - Moving closer to a rapid-learning health care system.
AU - Slutsky JR
Y1 - 2007/03/02/2007 Web-Exclusive Collection
N1 - Accession Number: 106283769. Language: English. Entry Date: 20070518. Revision Date: 20150711. Publication Type: Journal Article; commentary. Supplement Title: 2007 Web-Exclusive Collection. Original Study: Etheredge LM. Rapid learning: a new approach to diffusing research into practice. HEALTH AFFAIRS 2007; 2: s107-18. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 8303128.
KW - Health Care Delivery -- Administration
KW - Health Care Reform -- Administration
KW - Health Promotion
KW - Quality Assurance
KW - Decision Making, Organizational
KW - Health Policy
KW - Learning
KW - Physician-Patient Relations
KW - Public Health
KW - United States
SP - w122
EP - 4
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 26
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - This Perspective discusses activities that are necessary for developing a rapid-learning health system. Recognition of the central role that patients play in the successful evolution of such a system will help ensure that the goals of the transformation are met. Understanding the trade-offs of using a less controlled form of research to inform health care decision making and making necessary investments in methodology and translation will help secure the success of continuous-learning research. Major public policy interest in promoting health information technology and in getting more value for health care spending creates a framework for moving ahead.
SN - 0278-2715
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. jean.slutsky@ahrq.hhs.gov
U2 - PMID: 17259193.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106283769&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Charles Litton
T1 - Effectiveness of Various Concentrations of an Inert Gas Mixture for Preventing and Suppressing Mining Equipment Cab Fires: Development of a Dual Cab Fire Inerting System.
JO - Fire Technology
JF - Fire Technology
Y1 - 2007/03/06/
VL - 43
IS - 1
M3 - Article
SP - 29
EP - 44
SN - 00152684
AB - Abstract??The National Institute for Occupational Safety and Health (NIOSH/PRL) conducted a series of large-scale experiments to evaluate the effectiveness and safety of various concentrations of an inert gas mixture (CO2, 8%; N2, 50%; Ar, 42%) for preventing and suppressing cab fires. Comparison of concentrations effectiveness in yielding safe times has led to the choice of an optimum gas mixture concentration, discharged in the cab through a muffled nozzle system, for the development of a dual cab fire inerting system. Of note is that safety training programs, including the synchronization of performed tasks, need to accompany this technology to enhance operator?s efficiency and safety during fire emergencies within the safe times yielded by the cab fire inerting system.Cab fires are caused by the ignition of flammable vapors and mists (ball of fire) that penetrate the cab during prolonged hydraulic fluid and fuel fires, and electrical malfunctions involving other cab combustible materials. Often, these fires force the operator to exit the cab under hazardous conditions during a time needed to perform emergency tasks. Hence, it is important to provide the operator, not only with an engine fire suppression system (dry chemical powder), but also with a cab fire protection system, effective both in preventing the ignition of flammable vapors in the cab, and suppressing cab material fires. [ABSTRACT FROM AUTHOR]
AB - Copyright of Fire Technology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOBLE gases
KW - INDUSTRIAL safety
KW - FIRE prevention
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 24324375; Charles Litton 1; Affiliation: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health Research Physicist Pittsburgh PA USA Pittsburgh PA USA; Source Info: Mar2007, Vol. 43 Issue 1, p29; Subject Term: NOBLE gases; Subject Term: INDUSTRIAL safety; Subject Term: FIRE prevention; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zidan, Ahmed S.
AU - Sammour, Omaima A.
AU - Hammad, Mohammed A.
AU - Megrab, Nagia A.
AU - Habib, Muhammad J.
AU - Khan, Mansoor A.
T1 - Quality by design: Understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box–Behnken design and desirability function
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2007/03/06/
VL - 332
IS - 1/2
M3 - Article
SP - 55
EP - 63
SN - 03785173
AB - Abstract: Quality by design (QBD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A very useful component of the QBD is the understanding of factors and their interaction effects by a desired set of experiments. The present project deals with a case study to understand the effect of formulation variables of nanoemulsified particles of a model drug, cyclosporine A (CyA). A three-factor, three-level design of experiment (DOE) with response surface methodology (RSM) was run to evaluate the main and interaction effect of several independent formulation variables that included amounts of Emulphor El-620 (X 1), Capmul MCM-C8 (X 2) and 20% (w/w) CyA in sweet orange oil (X 3). The dependent variables included nanodroplets size (Y 1), nanoemulsions turbidity (Y 2), amounts released after 5 and 10min (Y 3, Y 4), emulsification rate (Y 5) and lag time (Y 6). A desirability function was used to minimize lag time and to maximize the other dependent variables. A mathematical relationship, Y 5 =9.09−0.37X 1 +0.37X 2 −0.45X 3 +0.732X 1 X 2 −0.62X 1 X 3 +0.3X 2 X 3 +0.02 −0.28 +0.471 (r 2 =0.92), was obtained to explain the effect of all factors and their colinearities on the emulsification rate. The optimized nanodroplets were predicted to yield Y 1, Y 2, Y 3, Y 4, Y 5 and Y 6 values of 42.1nm, 50.6NTU, 56.7, 107.2, 9.3%/min and 3.5min, respectively, when X 1, X 2, and X 3 values were 36.4, 70 and 10mg, respectively. A new batch was prepared with these levels of the independent variables to yield Y 1–Y 6 values that were remarkably close to the predicted values. In conclusion, this investigation demonstrated the potential of QBD in understanding the effect of the formulation variables on the quality of CyA self-nanoemulsified formulations. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOSPORINE
KW - DRUG delivery systems
KW - ORANGE oil
KW - CITRUS fruits
KW - Box–Behnken
KW - Cyclosporine
KW - Optimization
KW - Quality by design
KW - Self-nanoemulsification
N1 - Accession Number: 24046876; Zidan, Ahmed S. 1,2,3 Sammour, Omaima A. 2 Hammad, Mohammed A. 2 Megrab, Nagia A. 2 Habib, Muhammad J. 3 Khan, Mansoor A. 1; Email Address: Mansoor.Khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Food and Drug Administration, Maryland, USA 2: Faculty of Pharmacy, Zagazig University, Zagazig, Egypt 3: School of Pharmacy, Howard University, Washington, DC, USA; Source Info: Mar2007, Vol. 332 Issue 1/2, p55; Subject Term: CYCLOSPORINE; Subject Term: DRUG delivery systems; Subject Term: ORANGE oil; Subject Term: CITRUS fruits; Author-Supplied Keyword: Box–Behnken; Author-Supplied Keyword: Cyclosporine; Author-Supplied Keyword: Optimization; Author-Supplied Keyword: Quality by design; Author-Supplied Keyword: Self-nanoemulsification; NAICS/Industry Codes: 111320 Citrus (except Orange) Groves; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ijpharm.2006.09.060
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24046876&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williams, Anna J.
AU - Deck, Joanna
AU - Freeman, James P.
AU - Paul Chiarelli, M.
AU - Adjei, Michael D.
AU - Heinze, Thomas M.
AU - Sutherland, John B.
T1 - Biotransformation of flumequine by the fungus Cunninghamella elegans
JO - Chemosphere
JF - Chemosphere
Y1 - 2007/03/08/
VL - 67
IS - 2
M3 - Article
SP - 240
EP - 243
SN - 00456535
AB - The metabolism of the antibacterial fluoroquinolone drug flumequine by Cunninghamella elegans was investigated using cultures grown in Sabouraud dextrose broth with 308μM flumequine. The cultures were extracted with ethyl acetate; metabolites were separated by high-performance liquid chromatography and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Flumequine was transformed to two diastereomers of 7-hydroxyflumequine (23 and 43% of the total chromatographic peak area at 280nm) and 7-oxoflumequine (11% of the total peak area). This is the first time that the two 7-hydroxy diastereomers have been characterized structurally; the hydroxyflumequines are known to have less antimicrobial activity than flumequine. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTRANSFORMATION (Metabolism)
KW - FUNGI
KW - RESEARCH
KW - ANTI-infective agents
KW - OXIDATION
KW - HYDROXYLATION
KW - METABOLISM
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - NUCLEAR spectroscopy
KW - CHEMICAL ecology
KW - Fluoroquinolones
KW - Fungi
KW - Hydroxylation
KW - Oxidation
KW - Transformation
N1 - Accession Number: 23754054; Williams, Anna J. 1 Deck, Joanna 1 Freeman, James P. 2 Paul Chiarelli, M. 3 Adjei, Michael D. 1,4 Heinze, Thomas M. 2 Sutherland, John B. 1; Email Address: john.sutherland@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 3: Department of Chemistry, Loyola University, Chicago, IL 60626, USA 4: Norfolk Department of Public Health, 830 Southampton Avenue, Norfolk, VA 23510, USA; Source Info: Mar2007, Vol. 67 Issue 2, p240; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: FUNGI; Subject Term: RESEARCH; Subject Term: ANTI-infective agents; Subject Term: OXIDATION; Subject Term: HYDROXYLATION; Subject Term: METABOLISM; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: NUCLEAR spectroscopy; Subject Term: CHEMICAL ecology; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: Hydroxylation; Author-Supplied Keyword: Oxidation; Author-Supplied Keyword: Transformation; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.chemosphere.2006.10.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23754054&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Farb, Andrew
AU - Boam, Ashley B.
T1 - Stent Thrombosis Redux — The FDA Perspective.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2007/03/08/
VL - 356
IS - 10
M3 - Editorial
SP - 984
EP - 987
SN - 00284793
AB - The authors present the perspective of the U.S. Food and Drug Administration (FDA) on the safety of drug-eluting stents and the risk of thrombosis. The FDA concurs with its Circulatory System Devices Advisory Panel that when such stents are used for their approved indications, the risk of thrombosis does not outweigh their advantages over bare-metal stents.
KW - SURGICAL stents
KW - THROMBOSIS
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 24445233; Farb, Andrew 1 Boam, Ashley B. 2; Affiliation: 1: Medical officer of the Interventional Cardiology Devices Branch, of the Office of Device Evaluation, Center for Devices and Radiological Health, FDA, Rockville, MD 2: Chief of the Interventional Cardiology Devices Branch, of the Office of Device Evaluation, Center for Devices and Radiological Health, FDA, Rockville, MD; Source Info: 3/8/2007, Vol. 356 Issue 10, p984; Subject Term: SURGICAL stents; Subject Term: THROMBOSIS; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Editorial; Full Text Word Count: 1789
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24445233&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106281803
T1 - Stent thrombosis redux--the FDA perspective.
AU - Farb A
AU - Boam AB
Y1 - 2007/03/08/
N1 - Accession Number: 106281803. Language: English. Entry Date: 20070511. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Drug-Eluting Stents -- Adverse Effects
KW - Thrombosis -- Risk Factors
KW - Cardiovascular Risk Factors
KW - Clinical Trials
KW - Device Approval
KW - Drugs, Off-Label
KW - Myocardial Infarction -- Mortality
KW - Patient Safety
KW - Treatment Outcomes
KW - United States
KW - United States Food and Drug Administration
SP - 984
EP - 987
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 356
IS - 10
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Interventional Cardiology Devices Branch, of the Office of Device Evaluation, Center for Devices and Radiological Health, FDA, Rockville, USA.
U2 - PMID: 17296827.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106281803&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - C. Maldjian
AU - T. Patel
AU - R. Klein
AU - R. Smith
T1 - Efficacy of MRI in classifying proximal focal femoral deficiency.
JO - Skeletal Radiology
JF - Skeletal Radiology
Y1 - 2007/03/08/
VL - 36
IS - 3
M3 - Article
SP - 215
EP - 220
SN - 03642348
AB - AbstractObjective??To evaluate the efficacy of MRI in classifying PFFD and to compare MRI to radiographic classification of PFFD.Design??Radiographic and MRI classification of the cases was performed utilizing the Amstutz classification system.Patients??Retrospective evaluation of radiographs and MRI exams in nine hips of eight patients with proximal focal femoral deficiency was performed by two radiologists.Results??The cases were classified by radiographs as Amstutz 1: n=3, Amstutz 3: n=3, Amstutz 4: n=1 and Amstutz 5: n=2. The classifications based on MRI were Amstutz 1: n=6, Amstutz 2: n=1, Amstutz 3: n=0, Amstutz 4: n=2 and Amstutz 5: n=0. Three hips demonstrated complete agreement. There were six discordant hips. In two of the discordant cases, follow-up radiographs of 6 months or greater intervals were available and helped to confirm MRI findings. Errors in radiographic evaluation consisted of overestimating the degree of deficiency.Conclusion??MRI is more accurate than radiographic evaluation for the classification of PFFD, particularly early on, prior to the ossification of cartilaginous components in the femurs. Since radiographic evaluation tends to overestimate the degree of deficiency, MRI is a more definitive modality for evaluation of PFFD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Skeletal Radiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIC resonance imaging
KW - IMAGING systems in medicine
KW - FEMUR -- Diseases
KW - RADIOLOGY
KW - RADIOGRAPHY
N1 - Accession Number: 23931131; C. Maldjian 1 T. Patel 1 R. Klein 1 R. Smith 2; Affiliation: 1: New York Medical College 95 Grasslands Road Valhalla NY 10595 USA 95 Grasslands Road Valhalla NY 10595 USA 2: United States Food & Drug Administration Center for Devices and Radiological Health (CDRH) 9200 Corporate Boulevard Rockville MD 20850 USA 9200 Corporate Boulevard Rockville MD 20850 USA; Source Info: Mar2007, Vol. 36 Issue 3, p215; Subject Term: MAGNETIC resonance imaging; Subject Term: IMAGING systems in medicine; Subject Term: FEMUR -- Diseases; Subject Term: RADIOLOGY; Subject Term: RADIOGRAPHY; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23931131&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chang, Gwong-Jen J.
AU - Davis, Brent S.
AU - Stringfield, Cynthia
AU - Lutz, Christine
T1 - Prospective immunization of the endangered California condors (Gymnogyps californianus) protects this species from lethal West Nile virus infection
JO - Vaccine
JF - Vaccine
Y1 - 2007/03/08/
VL - 25
IS - 12
M3 - Article
SP - 2325
EP - 2330
SN - 0264410X
AB - Abstract: West Nile virus (WNV) has caused significant morbidity and mortality in humans, mammals, and both native and exotic birds in North America since its emergence in New York City in 1999 and its subsequent spread westward. Prior to the arrival of WNV to the western United States, prospective vaccination was conducted for the entire population of endangered California condors, both in captivity and in the wild. Here we show that this vaccine is safe for condors, stimulates protective immunity in adults, nestlings, and newly hatched chicks. Most importantly, we demonstrate protection of captive birds exposed to naturally circulating WNV during the 2004 transmission season. The prospective vaccination of the entire population of California condors before the arrival of WNV has thus potentially saved this endangered species from subsequent lethal WNV encephalitis, and possible extinction. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - West Nile virus
KW - Diseases
KW - Vaccination
KW - Encephalitis
KW - California condors
KW - DNA vaccine
N1 - Accession Number: 24047835; Chang, Gwong-Jen J. 1; Email Address: gxc7@cdc.gov; Davis, Brent S. 2; Stringfield, Cynthia 2; Lutz, Christine 2; Affiliations: 1: Division of Vector-Borne Infectious Diseases, National Center for Infectious Disease, Center for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, 3150 Rampart Road, CDC-Foothills Campus, Fort Collins, CO 80521, USA; 2: Los Angeles Zoo, Los Angeles, CA, USA; Issue Info: Mar2007, Vol. 25 Issue 12, p2325; Thesaurus Term: West Nile virus; Thesaurus Term: Diseases; Thesaurus Term: Vaccination; Thesaurus Term: Encephalitis; Author-Supplied Keyword: California condors; Author-Supplied Keyword: DNA vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.11.056
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xing-Hui Sun
AU - Flynn, Daniel C.
AU - Castranova, Vincent
AU - Millecchia, Lyndell L.
AU - Beardsley, Andrew R.
AU - Jun Liu
T1 - Identification of a Novel Domain at the N Terminus of Caveolin-1 That Controls Rear Polarization of the Protein and Caveolae Formation.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2007/03/09/
VL - 282
IS - 10
M3 - Article
SP - 7232
EP - 7241
SN - 00219258
AB - When cells are migrating, caveolin-1, the principal protein component of caveolae, is excluded from the leading edge and polarized at the cell rear. The dynamic feature depends on a specific sequence motif that directs intracellular trafficking of the protein. Deletion mutation analysis revealed a putative polarization domain at the N terminus of caveolin-1, between amino acids 32-60. Alanine substitution identified a minimal sequence of 10 residues (46TKEIDLVNRD55) necessary for caveolin-1 rear polarization. Interestingly, deletion of amino acids 1-60 did not prevent the polarization of caveolin-1 in human umbilical vein endothelial cells or wild-type mouse embryonic fibroblasts because of an interaction of Cav61-178 mutant with endogenous caveolin-1. Surprisingly, expression of the depolarization mutant in caveolin-1 null cells dramatically impeded caveolae formation. Furthermore, knockdown of caveolae formation by methyl-β-cyclodextrin failed to prevent wild-type caveolin-1 rear polarization. Importantly, genetic depletion of caveolin-1 led to disoriented migration, which can be rescued by full-length caveolin-1 but not the depolarization mutant, indicating a role of caveolin-1 polarity in chemotaxis. Thus, we have identified a sequence motif that is essential for caveolin-1 rear polarization and caveolae formation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - ALANINE
KW - MUTATION (Biology)
KW - CHEMOTAXIS
KW - FIBROBLASTS
KW - POLARITY (Biology)
KW - BLOOD-vessels
N1 - Accession Number: 24559117; Xing-Hui Sun 1 Flynn, Daniel C. 2,3 Castranova, Vincent 1,4 Millecchia, Lyndell L. 4 Beardsley, Andrew R. 1 Jun Liu 1,3; Email Address: junliu@hsc.wvu.edu; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26506 2: Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 3: Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 4: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgan town, West Virginia 26505; Source Info: 3/9/2007, Vol. 282 Issue 10, p7232; Subject Term: AMINO acids; Subject Term: ALANINE; Subject Term: MUTATION (Biology); Subject Term: CHEMOTAXIS; Subject Term: FIBROBLASTS; Subject Term: POLARITY (Biology); Subject Term: BLOOD-vessels; Number of Pages: 10p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1074/jbc.M607396200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24559117&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Yongsheng
AU - Brownell, Charles R.
AU - Sadrieh, Nakissa
AU - May, Joan C.
AU - Del Grosso, Alfred V.
AU - Lyon, Robbe C.
AU - Faustino, Patrick J.
T1 - Validation of an in vitro method for the determination of cyanide release from ferric-hexacyanoferrate: Prussian blue
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/03/12/
VL - 43
IS - 4
M3 - Article
SP - 1358
EP - 1363
SN - 07317085
AB - Abstract: Prussian blue (PB), ferric hexacyanoferrate, Fe4[Fe(CN)6]3 is indicated for the treatment of known or suspected internal contamination with radioactive cesium, radioactive thallium, or non-radioactive thallium. Owing to the molecular properties, cyanide is likely dissociated from PB under physiologically relevant pH conditions, thus raising a concern for the safety of the product. The objective of this study was to calibrate and validate a cyanide assay over a wide pH range (from 0.5 to 12) on the basis of Spectroquant cyanide test method (Merck). Merck''s photometric method requires that the measurement solution be within pH 5.5–6.0, hence samples and standards need to be adjusted to this pH range. Since the process of pH adjustment may have significant impact on the determination of cyanide, the analysis method needs to be optimized, calibrated and validated under each pH condition in the study. The validation characteristics included accuracy, precision, quantification limit, linearity, and stability. The intra-day accuracy ranged from 90% to 109% for the deionized water and solutions of pH 0.5–12. The intra-day precision (R.S.D.) ranged from 2.4% to 8.1% for the deionized water and solutions of pH 0.5–12. The analytical range was linear from 0.05 to 0.5ppm (mg/L). The R 2 ranged from 0.9925 to 0.9998. This validated method was successfully implemented to determine cyanide release from PB under various pH conditions (from 1.0 to 12) at different time-points (from 1 to 24h). [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRUSSIAN blue
KW - DRUGS -- Analysis
KW - DRUG development
KW - CHROMATOGRAPHIC analysis
KW - Cyanide
KW - Method validation
KW - Prussian blue
KW - Spectroquant cyanide-test kit
N1 - Accession Number: 24140609; Yang, Yongsheng 1 Brownell, Charles R. 1 Sadrieh, Nakissa 2 May, Joan C. 3 Del Grosso, Alfred V. 3 Lyon, Robbe C. 1 Faustino, Patrick J. 1; Email Address: faustinop@cder.fda.gov; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 2: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 3: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Laboratory of Analytical Chemistry, 5516 Nicholson Lane, Kensington, MD 20895, United States; Source Info: Mar2007, Vol. 43 Issue 4, p1358; Subject Term: PRUSSIAN blue; Subject Term: DRUGS -- Analysis; Subject Term: DRUG development; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Cyanide; Author-Supplied Keyword: Method validation; Author-Supplied Keyword: Prussian blue; Author-Supplied Keyword: Spectroquant cyanide-test kit; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2006.11.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Piccardo, Pedro
AU - Manson, Jean C.
AU - King, Declan
AU - Ghetti, Bernardino
AU - Barron, Rona M.
T1 - Accumulation of prion protein in the brain that is not associated with transmissible disease.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/03/13/
VL - 104
IS - 11
M3 - Article
SP - 4712
EP - 4717
SN - 00278424
AB - Prion diseases or transmissible spongiform encephalopathies are characterized histopathologically by the accumulation of prion protein (PrP) ranging from diffuse deposits to amyloid plaques. Moreover, pathologic PrP isoforms (PrPSc) are detected by immunoblot analysis and used both as diagnostic markers of disease and as indicators of the presence of infectivity in tissues. It is not known which forms of PrP are associated with infectivity. To address this question, we performed bioassays using human brain extracts from two cases with phenotypically distinct forms of familial prion disease (Gerstmann-Sträussler-Scheinker P102L). Both cases had PrP accumulations in the brain, but each had different PrPSc isoforms. Only one of the brains had spongiform degeneration. Tissue from this case transmitted disease efficiently to transgenic mice (Tg PrP1011.L), resulting in spongiform encephalopathy. In contrast, inoculation of tissue from the case with no spongiform degeneration resulted in almost complete absence of disease transmission but elicited striking PrP-amyloid deposition in several recipient mouse brains. Brains of these mice failed to transmit any neurological disease on passage, but PrP-amyloid deposition was again observed in the brains of recipient mice. These data suggest the possible isolation of an infectious agent that promotes PrP amyloidogenesis in the absence of a spongiform encephalopathy. Alternatively, the infectious agent may be rendered nonpathogenic by sequestration in amyloid plaques, or PrP amyloid can seed amyloid accumulation in the brain, causing a proteinopathy that is unrelated to prion disease. Formation of PrP amyloid may therefore not necessarily be a reliable marker of transmissible spongiform encephalopathy infectivity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC wasting disease
KW - PATHOLOGICAL histology
KW - TRANSGENIC mice
KW - MICE as laboratory animals
KW - AMYLOID
KW - BIOLOGICAL assay
KW - amyloid
KW - Gerstmann-Sträussler-Scheinker
KW - neurodegeneration
KW - transmissible spongiform encephalopathy
N1 - Accession Number: 24570500; Piccardo, Pedro 1,2 Manson, Jean C. 3 King, Declan 3 Ghetti, Bernardino 2 Barron, Rona M. 3; Email Address: rona.barron@bbsrc.ac.uk; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852 2: lndiana Alzheimer Disease Center and Division of Neuropathology, Indiana University School of Medicine, Indianapolis, IN 46202 3: Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh EH9 3JF, United Kingdom; Source Info: 3/13/2007, Vol. 104 Issue 11, p4712; Subject Term: CHRONIC wasting disease; Subject Term: PATHOLOGICAL histology; Subject Term: TRANSGENIC mice; Subject Term: MICE as laboratory animals; Subject Term: AMYLOID; Subject Term: BIOLOGICAL assay; Author-Supplied Keyword: amyloid; Author-Supplied Keyword: Gerstmann-Sträussler-Scheinker; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: transmissible spongiform encephalopathy; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1073/pnas.0609241104
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Richard Driscoll
AU - Bruce Bernard
AU - Christine West
T1 - Depressive Symptoms among Firefighters and Related Factors after the Response to Hurricane Katrina.
JO - Journal of Urban Health
JF - Journal of Urban Health
Y1 - 2007/03/14/
VL - 84
IS - 2
M3 - Article
SP - 153
EP - 161
SN - 10993460
AB - Abstract??The National Institute for Occupational Safety and Health conducted an evaluation regarding physical and psychological health symptoms among New Orleans firefighters 13?weeks after Hurricane Katrina struck the U.S. Gulf Coast on August 29, 2005. This report examines associations between depressive symptoms and concurrent comorbidity. Depressive symptoms were twice as likely among those with either lower respiratory symptoms or skin rash. Firefighters housed with their families were less likely to report depressive symptoms compared to those not living with their families. Perceived low supervisor support was associated with depressive symptoms, whereas participating in group counseling was not. The results underscore the need for the incorporation of physical and psychological health follow-up of emergency responders after natural disasters to better understand, monitor, and treat their health conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Urban Health is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMORBIDITY
KW - MENTAL depression
KW - FIRE fighters -- Health
KW - GROUP counseling
N1 - Accession Number: 24397006; Richard Driscoll 1 Bruce Bernard 1 Christine West 1; Affiliation: 1: National Institute for Occupational Safety and Health Division of Surveillance, Hazard Evaluations and Field Studies 4676 Columbia Parkway, R-10 Cincinnati OH USA 4676 Columbia Parkway, R-10 Cincinnati OH USA; Source Info: Mar2007, Vol. 84 Issue 2, p153; Subject Term: COMORBIDITY; Subject Term: MENTAL depression; Subject Term: FIRE fighters -- Health; Subject Term: GROUP counseling; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volokhov, Dmitriy V.
AU - Duperrier, Sandra
AU - Neverov, Alexander A.
AU - George, Joseph
AU - Buchrieser, Carmen
AU - Hitchins, Anthony D.
T1 - The Presence of the Internalin Gene in Natural Atypically Hemolytic Listeria innocua Strains Suggests Descent from L. monocytogenes.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/03/15/
VL - 73
IS - 6
M3 - Article
SP - 1928
EP - 1939
SN - 00992240
AB - The atypical hemolytic Listeria innocua strains PRL/NW 15B95 and J1-023 were previously shown to contain gene clusters analogous to the pathogenicity island (LIPI-1) present in the related foodborne gram-positive facultative intracellular pathogen Listeria monocytogenes, which causes listeriosis. LIPI-1 includes the hemolysin gene, thus explaining the hemolytic activity of the atypical L. innocua strains. No other L. monocytogenes-specific virulence genes were found to be present. In order to investigate whether any other specific L. monocytogenes genes could be identified, a global approach using a Listeria biodiversity DNA array was applied. According to the hybridization results, the isolates were defined as L. innocua strains containing LIPI-1. Surprisingly, evidence for the presence of the L. monocytogenes-specific inlA gene, previously thought to be absent, was obtained. The inlA gene codes for the InlA protein which enables bacterial entry into some nonprofessional phagocytic cells. PCR and sequence analysis of this region revealed that the flanking genes of the inlA gene at the upstream, 5′-end region were similar to genes found in L. monocytogenes serotype 4b isolates, whereas the organization of the downstream, 3′-end region was similar to that typical of L. innocua. Sequencing of the inlA region identified a small stretch reminiscent of the inlB gene of L. monocytogenes. The presence of two clusters of L. monocytogenes-specific genes makes it unlikely that PRL/NW 15B95 and J1-023 are L. innocua strains altered by horizontal transfer. It is more likely that they are distinct relics of the evolution of L. innocua from an ancestral L. monocytogenes, as postulated by others. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - GRAM-positive bacteria
KW - POLYMERASE chain reaction
KW - MICROBIAL diversity
KW - BIODIVERSITY
KW - VIRULENCE (Microbiology)
KW - PATHOGENIC microorganisms
KW - BACTERIAL genetics
KW - HYBRIDIZATION
N1 - Accession Number: 24570767; Volokhov, Dmitriy V. 1 Duperrier, Sandra 2 Neverov, Alexander A. 1 George, Joseph 1 Buchrieser, Carmen 2 Hitchins, Anthony D. 3; Email Address: Anthony.Hitchins@fda.hhs.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 208951 2: Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris Cedex 15, France 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740; Source Info: Mar2007, Vol. 73 Issue 6, p1928; Subject Term: LISTERIA monocytogenes; Subject Term: GRAM-positive bacteria; Subject Term: POLYMERASE chain reaction; Subject Term: MICROBIAL diversity; Subject Term: BIODIVERSITY; Subject Term: VIRULENCE (Microbiology); Subject Term: PATHOGENIC microorganisms; Subject Term: BACTERIAL genetics; Subject Term: HYBRIDIZATION; Number of Pages: 12p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1128/AEM.01796-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Timothy J.
AU - Wannemuehier, Yvonne M.
AU - Johnson, Sara J.
AU - Logue, Catherine M.
AU - White, David G.
AU - Doetkott, Curt
AU - Nolan, Lisa K.
T1 - Plasmid Replicon Typing of Commensal and Pathogenic Escherichia coli Isolates.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/03/15/
VL - 73
IS - 6
M3 - Article
SP - 1976
EP - 1983
SN - 00992240
AB - Despite the critical role of plasmids in horizontal gene transfer, few studies have characterized plasmid relatedness among different bacterial populations. Recently, a multiplex PCR replicon typing protocol was developed for classification of plasmids occurring in members of the Enterobacteriaceae. Here, a simplified version of this replicon typing procedure which requires only three multiplex panels to identify 18 plasmid replicons is described. This method was used to screen 1,015 Escherichia coli isolates of avian, human, and poultry meat origin for plasmid replicon types. Additionally, the isolates were assessed for their content of several colicin-associated genes. Overall, a high degree of plasmid variability was observed, with 221 different profiles occurring among the 1,015 isolates examined. IncFIB plasmids were the most common type identified, regardless of the source type of E. coli. IncFIB plasmids occurred significantly more often in avian pathogenic E. coli (APEC) and retail poultry E. coli (RPEC) than in uropathogenic E. coli (UPEC) and avian and human fecal commensal E. coli isolates (AFEC and HFEC, respectively). APEC and RPEC were also significantly more likely than UPEC, HFEC, and AFEC to possess the colicin-associated genes craC, cbi, and/or cma in conjunction with one or more plasmid replicons. The results suggest that E. coli isolates contaminating retail poultry are notably similar to APEC with regard to plasmid profiles, with both generally containing multiple plasmid replicon types in conjunction with colicin-related genes. In contrast, UPEC and human and avian commensal E. coli isolates generally lack the plasmid replicons and colicin-related genes seen in APEC and RPEC, suggesting limited dissemination of such plasmids among these bacterial populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMIDS
KW - GENETIC vectors
KW - ESCHERICHIA coli
KW - ENTEROBACTERIACEAE
KW - GRAM-negative bacteria
KW - MICROORGANISMS -- Population biology
KW - POLYMERASE chain reaction
KW - GENETIC transformation
KW - MICROBIOLOGY
N1 - Accession Number: 24570772; Johnson, Timothy J. 1 Wannemuehier, Yvonne M. 1 Johnson, Sara J. 1 Logue, Catherine M. 2 White, David G. 3 Doetkott, Curt 2 Nolan, Lisa K. 1; Email Address: Iknolan@iastate.edu; Affiliation: 1: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, 1802 Elwood Drive, J'MRI #2, Iowa State University, Ames, Iowa 50011 2: US. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, Maryland 20708 3: Information Technology Services, North Dakota State University, Fargo, North Dakota 581052; Source Info: Mar2007, Vol. 73 Issue 6, p1976; Subject Term: PLASMIDS; Subject Term: GENETIC vectors; Subject Term: ESCHERICHIA coli; Subject Term: ENTEROBACTERIACEAE; Subject Term: GRAM-negative bacteria; Subject Term: MICROORGANISMS -- Population biology; Subject Term: POLYMERASE chain reaction; Subject Term: GENETIC transformation; Subject Term: MICROBIOLOGY; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1128/AEM.02171-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24570772&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karnaukhova, Elena
T1 - Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
Y1 - 2007/03/15/
VL - 73
IS - 6
M3 - Article
SP - 901
EP - 910
SN - 00062952
AB - Abstract: Human serum albumin (HSA), a major plasma protein and plasma-derived therapeutic, interacts with a wide variety of drugs and native plasma metabolites. In this study the interactions between HSA and small lipophilic molecules all-trans retinoic acid (RA), all-trans retinaldehyde (retinal, RAL) and all-trans retinyl acetate (RAC) were investigated by UV–vis absorption spectroscopy, fluorescence spectroscopy and circular dichroism (CD). This paper focuses on investigation of the interactions between HSA and RA by the visible CD. RAL and RAC were used in this study due to their structural identity to RA to elucidate the importance of the end functional group for the complex formation. Our data demonstrate that RA specifically binds to HSA in a stable non-covalent complex at least at two internal binding sites with close but distinct affinities. Upon titration of HSA with RA, visible CD spectra clearly demonstrate the appearance of a well-defined induced positive Cotton Effect (CE) around 350nm. Beyond ligand-to-protein ratio of 0.8 and up to saturation (2.0), CD exhibits two major bands of opposite signs, suggesting exciton coupling between the chromophore molecules in the protein interior. The fluorescence quenching data suggest proximity of the primary RA binding site to tryptophan (W214). RAC shows a weak association with HSA with stoichiometry close to that of RA, while interactions of RAL with HSA proceed non-specifically at multiple sites. Contrary to RA, the adducts of HSA with RAC and RAL do not show any induced chirality, thus indicating that despite their high structural similarity to RA, both compounds do not appear to occupy the internal binding sites, but associate with the protein exterior. [Copyright &y& Elsevier]
AB - Copyright of Biochemical Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - BLOOD proteins
KW - FLUORESCENCE
KW - CHEMICAL ecology
KW - absorbance ( UV–vis )
KW - all-trans retinaldehyde ( RAL )
KW - all-trans retinoic acid ( RA )
KW - all-trans retinyl acetate ( RAC )
KW - Circular dichroism
KW - circular dichroism ( CD )
KW - Cotton Effect ( CE )
KW - fatty acid ( FA )
KW - Human serum albumin
KW - human serum albumin ( HSA )
KW - ligand-to-protein (molar) ratio ( L/P )
KW - phosphate buffer saline ( PBS )
KW - Protein-induced chirality
KW - Retinal
KW - Retinoic acid
KW - Retinyl acetate
N1 - Accession Number: 24046019; Karnaukhova, Elena 1; Email Address: elena.karnaukhova@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Mar2007, Vol. 73 Issue 6, p901; Subject Term: BLOOD plasma; Subject Term: BLOOD proteins; Subject Term: FLUORESCENCE; Subject Term: CHEMICAL ecology; Author-Supplied Keyword: absorbance ( UV–vis ); Author-Supplied Keyword: all-trans retinaldehyde ( RAL ); Author-Supplied Keyword: all-trans retinoic acid ( RA ); Author-Supplied Keyword: all-trans retinyl acetate ( RAC ); Author-Supplied Keyword: Circular dichroism; Author-Supplied Keyword: circular dichroism ( CD ); Author-Supplied Keyword: Cotton Effect ( CE ); Author-Supplied Keyword: fatty acid ( FA ); Author-Supplied Keyword: Human serum albumin; Author-Supplied Keyword: human serum albumin ( HSA ); Author-Supplied Keyword: ligand-to-protein (molar) ratio ( L/P ); Author-Supplied Keyword: phosphate buffer saline ( PBS ); Author-Supplied Keyword: Protein-induced chirality; Author-Supplied Keyword: Retinal; Author-Supplied Keyword: Retinoic acid; Author-Supplied Keyword: Retinyl acetate; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bcp.2006.11.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bialek, Stephanie R.
AU - George, Prethiba A.
AU - Guo-Liang Xia
AU - Glatzer, Marc B.
AU - Motes, Miles L.
AU - Veazey, John E.
AU - Hammond, Roberta M.
AU - Jones, Timothy
AU - Shieh, Y. Carol
AU - Wamnes, Janet
AU - Vaughan, Gilberto
AU - Khudyakov, Yury
AU - Fiore, Anthony E.
T1 - Use of Molecular Epidemiology to Confirm a Multistate Outbreak of Hepatitis A Caused by Consumption of Oysters.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/03/15/
VL - 44
IS - 6
M3 - Article
SP - 838
EP - 840
SN - 10584838
AB - The 39 oyster consumption-related cases of hepatitis A reported in 2005 represent the first large outbreak of hepatitis A associated with shellfish consumption in the United States in >15 years. This is the first outbreak investigation in which an identical hepatitis A virus sequence was obtained from both the implicated food product and case patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterovirus diseases
KW - Molecular epidemiology
KW - Hepatitis viruses
KW - Hepatitis A
KW - Hepatitis associated antigen
KW - Patients
N1 - Accession Number: 24102182; Bialek, Stephanie R. 1; Email Address: sbialek@cdc.gov; George, Prethiba A. 1; Guo-Liang Xia 1; Glatzer, Marc B. 2; Motes, Miles L. 3; Veazey, John E. 4; Hammond, Roberta M. 5; Jones, Timothy 6; Shieh, Y. Carol 7; Wamnes, Janet 8; Vaughan, Gilberto 1; Khudyakov, Yury 1; Fiore, Anthony E. 1; Affiliations: 1: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia.; 2: US Food and Drug Administration, Florida.; 3: US Food and Drug Administration, Mobile, Alabama.; 4: US Food and Drug Administration, Baton Rouge, Louisiana.; 5: Florida Department of Health/Bureau of Community Environmental Health, Tallahassee, Florida.; 6: Tennessee Department of Health, Nashville.; 7: Food and Drug Administration Gulf Coast Seafood Laboratory, Dauphin Island, Alabama.; 8: Florida Department of Health, Fort Pierce, Florida.; Issue Info: 3/15/2007, Vol. 44 Issue 6, p838; Thesaurus Term: Enterovirus diseases; Thesaurus Term: Molecular epidemiology; Thesaurus Term: Hepatitis viruses; Subject Term: Hepatitis A; Subject Term: Hepatitis associated antigen; Subject Term: Patients; Number of Pages: 3p; Document Type: Article
L3 - 10.1086/511874
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - David Jacobson-Kram
AU - Joseph F. Contrera
T1 - Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part I: Early Screening for Potential Human Mutagens.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2007/03/15/
VL - 96
IS - 1
M3 - Article
SP - 16
EP - 20
SN - 10966080
AB - Results of genetic toxicology tests are used by FDA's Center for Drug Evaluation and Research as a surrogate for carcinogenicity data during the drug development process. Mammalian in vitro assays have a high frequency of positive results which can impede or derail the drug development process. To reduce the risk of such delays, most pharmaceutical companies conduct early non-GLP (good laboratory practices) studies to eliminate drug candidate with mutagenic or clastogenic activity. Early screens include in silico structure activity assessments and various iterations of the ultimate regulatory mandated GLP studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTAGENS
KW - TOXICOLOGY
KW - DRUG development
KW - CARCINOGENICITY
N1 - Accession Number: 25520992; David Jacobson-Kram 1 Joseph F. Contrera 2; Affiliation: 1: Office of New Drugs 2: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Mar2007, Vol. 96 Issue 1, p16; Subject Term: MUTAGENS; Subject Term: TOXICOLOGY; Subject Term: DRUG development; Subject Term: CARCINOGENICITY; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tyurina, Yulia Y.
AU - Basova, Liana V.
AU - Konduru, Nagarjun V.
AU - Tyurin, Vladimir A.
AU - Potapovich, Ala I.
AU - Cai, Peter
AU - Bayir, Hülya
AU - Stoyanovsky, Detcho
AU - Pitt, Bruce R.
AU - Shvedova, Anna A.
AU - Fadeel, Bengt
AU - Kagan, Valerian E.
T1 - Nitrosative Stress Inhibits the Aminophospholipid Translocase Resulting in Phosphatidylserine Externalization and Macrophage Engulfment.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2007/03/16/
VL - 282
IS - 11
M3 - Article
SP - 8498
EP - 8509
SN - 00219258
AB - Macrophage recognition of apoptotic cells depends on externalization of phosphatidylserine (PS), which is normally maintained within the cytosolic leaflet of the plasma membrane by aminophospholipid translocase (APLT). APLT is sensitive to redox modifications of its -SH groups. Because activated macrophages produce reactive oxygen and nitrogen species, we hypothesized that macrophages can directly participate in apoptotic cell clearance by S-nitrosylation/oxidation and inhibition of APLT causing PS externalization. Here we report that exposure of target HL-60 cells to nitrosative stress inhibited APLT, induced PS externalization, and enhanced recognition and elimination of ‘nitrosatively’ modified cells by RAW 264.7 macrophages. Using S-nitroso-L-cysteine-ethyl ester (SNCEE) and S-nitrosoglutathione (GSNO) that cause intracellular and extra-cellular trans-nitrosylation of proteins, respectively, we found that SNCEE (but not GSNO) caused significant S-nitrosylation/oxidation of thiols in HL-60 cells. SNCEE also strongly inhibited APLT, activated scramblase, and caused PS externalization. However, SNCEE did not induce caspase activation or nuclear condensation/fragmentation suggesting that PS externalization was dissociated from the common apoptotic pathway. Dithiothreitol reversed SNCEE-induced S-nitrosylation, APLT inhibition, and PS externalization. SNCEE but not GSNO stimulated phagocytosis of HL-60 cells. Moreover, phagocytosis of target cells by lipopolysaccharide-stimulated macrophages was significantly suppressed by an NO• scavenger, DAF-2. Thus, macrophage-induced nitrosylation/oxidation plays an important role in cell clearance, and hence in the resolution of inflammation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATIDYLSERINES
KW - MACROPHAGES
KW - CYTOSOL
KW - ACTIVE oxygen
KW - OXIDATION
KW - APOPTOSIS
KW - THIOLS
KW - PHAGOCYTOSIS
N1 - Accession Number: 24717258; Tyurina, Yulia Y. 1 Basova, Liana V. 1 Konduru, Nagarjun V. 1 Tyurin, Vladimir A. 1 Potapovich, Ala I. 1 Cai, Peter 1 Bayir, Hülya 1,2 Stoyanovsky, Detcho 3 Pitt, Bruce R. 1 Shvedova, Anna A. 4 Fadeel, Bengt 5 Kagan, Valerian E. 6,7; Email Address: kagan@pitt.edu; Affiliation: 1: Center for Free Radical and Antioxidant Health, Departments of Environmental and Occupational Health 2: Department of Critical Care Medicine,, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 3: Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 4: National Institute of Occupational Safety and Health, Morgantown, West Virginia 26505 5: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden 6: Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 7: Department of Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219; Source Info: 3/16/2007, Vol. 282 Issue 11, p8498; Subject Term: PHOSPHATIDYLSERINES; Subject Term: MACROPHAGES; Subject Term: CYTOSOL; Subject Term: ACTIVE oxygen; Subject Term: OXIDATION; Subject Term: APOPTOSIS; Subject Term: THIOLS; Subject Term: PHAGOCYTOSIS; Number of Pages: 12p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1074/jbc.M606950200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Belongia, E.
AU - Izurieta, H.
AU - Braun, M. M.
AU - Ball, R.
AU - Haber, P.
AU - Baggs, J.
AU - Weintraub, E.
AU - Gargiullo, P.
AU - Vellozzi, C.
AU - Iskander, J.
AU - Patel, M.
AU - Parashar, U.
AU - Cortese, M.
T1 - Postmarketing Monitoring of Intussusception After RotaTeq Vaccination -- United States, February 1, 2006-February 15, 2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2007/03/16/
VL - 56
IS - 10
M3 - Article
SP - 218
EP - 222
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article presents data from the postmarketing monitoring of intussusception events after RotaTeq vaccination in the U.S. from February 1, 2006 to February 15, 2007. It details all the intussusception reports received by the Vaccine Adverse Event Reporting System during the period. It discusses the result of the postmarketing study on the safety of RotaTeq, which was developed by Merck and Co.
KW - DRUG monitoring
KW - CLINICAL drug trials
KW - VACCINATION -- Complications
KW - INTUSSUSCEPTION in children
KW - VACCINATION of children
KW - UNITED States
KW - MERCK & Co. Inc.
N1 - Accession Number: 24442610; Belongia, E. 1 Izurieta, H. 2 Braun, M. M. 2 Ball, R. 2 Haber, P. Baggs, J. Weintraub, E. Gargiullo, P. Vellozzi, C. Iskander, J. Patel, M. Parashar, U. Cortese, M.; Affiliation: 1: Marshfield Clinic, Marshfield, Wisconsin 2: Center for Biologics Evaluation and Research, Food and Drug Admin; Source Info: 3/16/2007, Vol. 56 Issue 10, p218; Subject Term: DRUG monitoring; Subject Term: CLINICAL drug trials; Subject Term: VACCINATION -- Complications; Subject Term: INTUSSUSCEPTION in children; Subject Term: VACCINATION of children; Subject Term: UNITED States; Company/Entity: MERCK & Co. Inc. DUNS Number: 001317064 Ticker: MRK; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - John F. Young
AU - Richard H. Luecke
AU - Daniel R. Doerge
T1 - Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Acrylamide and Its Metabolites in Mice, Rats, and Humans.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2007/03/19/
VL - 20
IS - 3
M3 - Article
SP - 388
EP - 399
SN - 0893228X
AB - A physiologically based pharmacokinetic model was developed for acrylamide (AA) and three of its metabolites: glycidamide (GA) and the glutathione conjugates of acrylamide (AA-GS) and glycidamide (GA-GS). Liver GA−DNA adducts and hemoglobin (Hb) adducts with AA and GA were included as pharmacodynamic components of the model. Serum AA and GA concentrations combined with urinary elimination levels for all four components from male and female mice and rats were simulated from iv and oral administration of 0.1 mg/kg AA or 0.12 mg/kg GA. Adduct formation and decay rates were determined from a 6 week exposure to approximately 1 mg/kg AA in the drinking water and subsequent 6 week nonexposure period. Human urinary excretion data and Hb adduct data were utilized to extrapolate to a human model. The steady-state human liver GA−DNA adduct level from exposure to background levels of AA in the diet was predicted to be between 0.06 and 0.26 adducts per 108nucleotides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Research in Toxicology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLAMIDE
KW - METABOLITES
KW - GLUTATHIONE
KW - DNA adducts
N1 - Accession Number: 24512755; John F. Young 1 Richard H. Luecke 1 Daniel R. Doerge 1; Affiliation: 1: Divisions of Biometry & Risk Assessment and Biochemical Toxicology, National Center forToxicological Research (NCTR)/Food and Drug Administration, Jefferson, Arkansas 72079, andDepartment of Chemical Engineering, University of MissouriColumbia, Columbia, Missouri 65211; Source Info: Mar2007, Vol. 20 Issue 3, p388; Subject Term: ACRYLAMIDE; Subject Term: METABOLITES; Subject Term: GLUTATHIONE; Subject Term: DNA adducts; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Robert J. Turesky
AU - Angela K. Goodenough
AU - Weijuan Ni
AU - Lynn McNaughton
AU - David M. LeMaster
AU - Ricky D. Holland
AU - Rebekah W. Wu
AU - James S. Felton
T1 - Identification of 2-Amino-1,7-dimethylimidazo4,5-gquinoxaline: An Abundant Mutagenic Heterocyclic Aromatic Amine Formed in Cooked Beef.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2007/03/19/
VL - 20
IS - 3
M3 - Article
SP - 520
EP - 530
SN - 0893228X
AB - A previously unknown isomer of the carcinogenic heterocyclic aromatic amine (HAA) 2-amino-3,8-dimethylimidazo4,5-fquinoxaline (8-MeIQx) was recently discovered in the urine of meat eaters and subsequently detected in cooked ground beef (Holland, R.D., et al. (2004) Chem. Res. Toxicol. 17,1121−1136). In this current investigation, the identity of the analyte was determined through a comparison of its chromatographic tRby HPLC and through UV and mass spectral comparisons to the synthesized isomers of 8-MeIQx. Angular tricyclic isomers of 8-MeIQx were excluded as potential structures of the newly discovered HAA, on the basis of dissimilar tRand product ion mass spectral data. The linear tricyclic isomers 2-amino-1,6-dimethylimidazo4,5-gquinoxaline (6-MeIgQx) and 2-amino-1,7-dimethylimidazo4,5-gquinoxaline (7-MeIgQx) were postulated as plausible structures. Both compounds were synthesized from 4-fluoro-5-nitro-benzene-1,2-diamine in five steps. The structure of the analyte was proven to be 7-MeIgQx, on the basis of co-injection of the compound with the synthetic isomers, and corroborated by comparisons of the UV and mass spectral data of the analyte and MeIgQx isomers. 7-MeIgQx induced 348 revertants/g in the S. typhimuriumtester strain YG1024, when liver S-9 homogenate of rats pretreated with polychlorinated biphenyls (PCBs) was used for bioactivation. This newly discovered 7-MeIgQx molecule is one of the most abundant HAAs formed in cooked ground beef patties and pan-fried scrapings. The human health risk of 7-MeIgQx requires investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Research in Toxicology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AROMATIC amines
KW - POLYCHLORINATED biphenyls
KW - NITROAROMATIC compounds
KW - ORGANOCHLORINE compounds
N1 - Accession Number: 24512769; Robert J. Turesky 1 Angela K. Goodenough 1 Weijuan Ni 1 Lynn McNaughton 1 David M. LeMaster 1 Ricky D. Holland 1 Rebekah W. Wu 1 James S. Felton 1; Affiliation: 1: Division of Environmental Disease Prevention and Division of Molecular Medicine, New York State Departmentof Health, Albany, New York 12201, Division of System Toxicology, National Center for Toxicological Research,U.S. Food and Drug Administration, Jefferson, Arkansas 72079, and Chemistry, Materials and Life SciencesDirectorate, P.O. Box 808, Lawrence Livermore National, Laboratory, Livermore, California 94551; Source Info: Mar2007, Vol. 20 Issue 3, p520; Subject Term: AROMATIC amines; Subject Term: POLYCHLORINATED biphenyls; Subject Term: NITROAROMATIC compounds; Subject Term: ORGANOCHLORINE compounds; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wong, Hin-chung
AU - Liu, Shu-Hui
AU - Chiou, Chien-Shun
AU - Nishibuchi, Mitsuaki
AU - Lee, Bok-Kwon
AU - Suthienkul, Orasa
AU - Nair, Gopinath Balakrish
AU - Kaysner, Charles A.
AU - Taniguchi, Hatsumi
T1 - A pulsed-field gel electrophoresis typing scheme for Vibrio parahaemolyticus isolates from fifteen countries
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2007/03/20/
VL - 114
IS - 3
M3 - Article
SP - 280
EP - 287
SN - 01681605
AB - Abstract: Vibrio parahaemolyticus is an important foodborne pathogen in Taiwan and many other maritime Asian countries where seafood is frequently consumed. A total of 535 strains of V. parahaemolyticus were recovered mostly (97%) from clinical samples obtained in Taiwan or in 14 other countries. These strains were typed by pulsed-field gel electrophoresis following SfiI digestion and a typing scheme was generated. The 115 different patterns identified were grouped into 13 types with dissimilarity values less than 15, plus 16 miscellaneous patterns not grouped into any of the types. Types I, A, D and J contained the most patterns, with the numbers of patterns being 17, 13, 12, and 11, respectively. However, types I, B, D, A, H and C contained the most strains, with the numbers of strains being 204, 73, 71, 54, 29 and 25, respectively. Type I consisted exclusively of the pandemic O3:K6 strains and genetically closely related strains. This PFGE typing scheme for V. parahaemolyticus could be used for the characterization of pathogenic isolates. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - Pathogenic microorganisms
KW - Pulsed-field gel electrophoresis
KW - Vibrio parahaemolyticus
KW - Typing scheme
N1 - Accession Number: 24138369; Wong, Hin-chung 1; Email Address: wonghc@scu.edu.tw; Liu, Shu-Hui 1; Chiou, Chien-Shun 2; Nishibuchi, Mitsuaki 3; Lee, Bok-Kwon 4; Suthienkul, Orasa 5; Nair, Gopinath Balakrish 6; Kaysner, Charles A. 7; Taniguchi, Hatsumi 8; Affiliations: 1: Department of Microbiology, Soochow University, Taipei, Taiwan 111, Republic of China; 2: Branch Office III, Center for Disease Control, Taichung, Taiwan 408, Republic of China; 3: Center for Southeast Asian Studies, Kyoto University, Kyoto 606-8501, Japan; 4: Laboratory of Enteric Infection, Department of Microbiology, National Institute of Health, Seoul, Republic of Korea; 5: Department of Microbiology, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand; 6: National Institute of Cholera and Enteric Diseases, P-33, CIT Road Scheme XM, Beliaghata, Calcutta-700 010, India; 7: Seafood Products Research Center, Food and Drug Administration, Bothell, Washington 98041, USA; 8: Department of Microbiology, University of OCCUP, and Unviron Health School of Medicine Yahatauishi, Kitakyshu 807-8555, Japan; Issue Info: Mar2007, Vol. 114 Issue 3, p280; Thesaurus Term: Food pathogens; Thesaurus Term: Pathogenic microorganisms; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Vibrio parahaemolyticus; Author-Supplied Keyword: Typing scheme; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2006.09.024
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Santiago, César
AU - Ballesteros, Angela
AU - Tami, Cecilia
AU - Martínez-Muñoz, Laura
AU - Kaplan, Gerardo G.
AU - Casasnovas, José M.
T1 - Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family
JO - Immunity
JF - Immunity
Y1 - 2007/03/23/
VL - 26
IS - 3
M3 - Article
SP - 299
EP - 310
SN - 10747613
AB - Summary: The T cell immunoglobulin mucin (TIM) receptors are involved in the regulation of immune responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of the murine mTIM-1 and mTIM-2 receptors revealed an immunoglobulin (Ig) fold, with four Cys residues bridging a distinctive CC′ loop to the GFC β-sheet. The structures showed two ligand-recognition modes in the TIM family. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding. Biochemical, mutational, and cell adhesion analyses confirmed the divergent ligand-binding modes revealed by the structures. Structural features characteristic of mTIM-1 appear conserved in human TIM-1, which also mediated homophilic interactions. The extracellular mucin domain enhanced binding through the Ig domain, modulating TIM receptor functions. These results explain the divergent immune functions described for the murine receptors and the role of TIM-1 as a cell adhesion receptor in renal regeneration and cancer. [Copyright &y& Elsevier]
AB - Copyright of Immunity is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cell receptors
KW - AUTOIMMUNITY
KW - LIGAND binding (Biochemistry)
KW - IMMUNOGLOBULINS
KW - MOLIMMUNO
KW - PROTEINS
KW - SIGNALING
N1 - Accession Number: 24387591; Santiago, César 1 Ballesteros, Angela 1 Tami, Cecilia 2 Martínez-Muñoz, Laura 1 Kaplan, Gerardo G. 2 Casasnovas, José M. 1; Email Address: jcasasnovas@cnb.uam.es; Affiliation: 1: Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autónoma, 28049 Madrid, Spain 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Mar2007, Vol. 26 Issue 3, p299; Subject Term: T cell receptors; Subject Term: AUTOIMMUNITY; Subject Term: LIGAND binding (Biochemistry); Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: MOLIMMUNO; Author-Supplied Keyword: PROTEINS; Author-Supplied Keyword: SIGNALING; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.immuni.2007.01.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koizumi, Shinji
AU - Gong, Pengfei
AU - Suzuki, Kaoru
AU - Murata, Mie
T1 - Cadmium-responsive Element of the Human Heme Oxygenase-1 Gene Mediates Heat Shock Factor 1-dependent Transcriptional Activation.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2007/03/23/
VL - 282
IS - 12
M3 - Article
SP - 8715
EP - 8723
SN - 00219258
AB - Transcription of a number of mammalian genes is activated by heavy metals, but mechanisms of signaling and transcriptional regulation are not well understood. From a comparison of heavy metal responses of several human genes, it was noted that the heme oxygenase-1 (HO-1) gene is quite similar in the spectrum of metal response and induction kinetics to the heat shock protein 70 (HSP70) gene, suggesting a common regulatory mechanism shared by these genes. The cadmium-responsive element (CdRE) known to be responsible for the metal regulation of ho-1 formed complexes with proteins from heavy metal-treated HeLa cells in an electrophoretic mobility shift assay (EMSA). These complexes were indistinguishable in mobility from those formed by the heat shock factor 1 (HSF1) and the heat shock element involved in hsp70 regulation, suggesting the involvement of HSF1 also in the CdRE complexes. Competitive EMSA and supershift analysis with an anti-HSF1 antibody revealed that HSF1 was in fact a component of the CdRE complexes. A fine analysis on the affinity of HSF1 to a series of mutant CdRE sequences showed that HSF1 recognizes a sequence motif TnCTAGA. Transient transfection analysis with overexpressed recombinant HSF1 demonstrated that CdRE has HSF1-dependent enhancer-like activity that requires direct binding of HSF1. In the absence of overexpressed HSF1, however, CdRE by itself was insufficient to mediate heavy metal-induced transcription, suggesting requirement of additional regulatory sequences. The finding that HSF1 is directly involved in the regulation of ho-1 with an anti-oxidative role revealed a new aspect of the biological defense mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM
KW - OXYGENASES
KW - HEAT shock proteins
KW - GENES
KW - HEAVY metals
KW - OXIDATION
KW - SPECTRUM analysis
KW - IMMUNOGLOBULINS
N1 - Accession Number: 24812242; Koizumi, Shinji 1; Email Address: koizumi@h.jniosh.go.jp Gong, Pengfei 1 Suzuki, Kaoru 1 Murata, Mie 1; Affiliation: 1: Mechanism of Health Effect Research Group, National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan; Source Info: 3/23/2007, Vol. 282 Issue 12, p8715; Subject Term: CADMIUM; Subject Term: OXYGENASES; Subject Term: HEAT shock proteins; Subject Term: GENES; Subject Term: HEAVY metals; Subject Term: OXIDATION; Subject Term: SPECTRUM analysis; Subject Term: IMMUNOGLOBULINS; Number of Pages: 9p; Illustrations: 9 Graphs; Document Type: Article
L3 - 10.1074/jbc.M609427200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de Jager, Lowri S.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Determination of coumarin, vanillin, and ethyl vanillin in vanilla extract products: liquid chromatography mass spectrometry method development and validation studies
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2007/03/23/
VL - 1145
IS - 1/2
M3 - Article
SP - 83
EP - 88
SN - 00219673
AB - Abstract: A LC–MS method was developed for the determination of coumarin, vanillin, and ethyl vanillin in vanilla products. Samples were analyzed using LC–electrospray ionization (ESI)–MS in the positive ionization mode. Limits of detection for the method ranged from 0.051 to 0.073μgmL−1. Using the optimized method, 24 vanilla products were analyzed. All samples tested negative for coumarin. Concentrations ranged from 0.38 to 8.59mgmL−1 () for vanillin and 0.33 to 2.27mgmL−1 () for ethyl vanillin. The measured concentrations are compared to values calculated using UV monitoring and to results reported in a similar survey in 1988. Analytical results, method precision, and accuracy data are presented. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food additives
KW - Anticoagulants (Medicine)
KW - Flavoring essences
KW - Essences & essential oils
KW - Coumarin
KW - LC–MS
KW - Mass spectrometry
KW - Vanilla extracts
KW - Vanillin
N1 - Accession Number: 24217970; de Jager, Lowri S.; Email Address: lowri.dejager@fda.hhs.gov; Perfetti, Gracia A. 1; Email Address: gracia.perfetti@fda.hhs.gov; Diachenko, Gregory W. 1; Email Address: gregory.diachenko@fda.hhs.gov; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, USA; Issue Info: Mar2007, Vol. 1145 Issue 1/2, p83; Thesaurus Term: Food additives; Subject Term: Anticoagulants (Medicine); Subject Term: Flavoring essences; Subject Term: Essences & essential oils; Author-Supplied Keyword: Coumarin; Author-Supplied Keyword: LC–MS; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Vanilla extracts; Author-Supplied Keyword: Vanillin; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 311930 Flavoring Syrup and Concentrate Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.chroma.2007.01.039
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wagner, Gregory R.
T1 - The fallout from asbestos.
JO - Lancet
JF - Lancet
Y1 - 2007/03/24/
VL - 369
IS - 9566
M3 - Article
SP - 973
EP - 974
SN - 00995355
AB - The article discusses a more extensive report by Ro-Ting Lin and his colleagues in the March 10, 2007 issue of "Lancet" that focused on the long-term effects of asbestos exposure. Long-term exposure risks include mesothelioma and asbestosis, as well as lung cancer, laryngeal tumors, and perhaps malignant disorders of the gastrointestinal tract. Public policy towards asbestos is discussed, including the European Union's ban on the general production and marketing of asbestos. The use of "safe" chysotile asbestos is discussed. In advanced countries such as the United States, the primary challenge is in the removal of old asbestos during demolition and repair projects.
KW - ASBESTOS
KW - ASBESTOSIS
KW - CONTAMINATION (Technology)
KW - INDUSTRIAL wastes
KW - ASBESTOS abatement
KW - ENVIRONMENTAL health
KW - HAZARDOUS substances
KW - LANCET, The (Periodical)
N1 - Accession Number: 24471589; Wagner, Gregory R. 1; Email Address: gwagner@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Washington, DC 20201, USA; Source Info: 3/24/2007, Vol. 369 Issue 9566, p973; Subject Term: ASBESTOS; Subject Term: ASBESTOSIS; Subject Term: CONTAMINATION (Technology); Subject Term: INDUSTRIAL wastes; Subject Term: ASBESTOS abatement; Subject Term: ENVIRONMENTAL health; Subject Term: HAZARDOUS substances; Reviews & Products: LANCET, The (Periodical); NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562210 Waste treatment and disposal; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105959835
T1 - The fallout from asbestos.
AU - Wagner GR
Y1 - 2007/03/24/
N1 - Accession Number: 105959835. Language: English. Entry Date: 20080208. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Lancet 2007 March 10; 369(9564): 844-9. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 2985213R.
KW - Asbestos -- Adverse Effects
KW - Mesothelioma -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Pneumoconiosis -- Etiology
KW - Mesothelioma -- Mortality
KW - Occupational Exposure -- Economics
KW - Occupational Exposure -- Legislation and Jurisprudence
KW - Pneumoconiosis -- Mortality
KW - Time Factors
KW - World Health
SP - 973
EP - 974
JO - Lancet
JF - Lancet
JA - LANCET
VL - 369 North American Edition
IS - 9566
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - National Institute for Occupational Safety and Health, Washington, DC 20201; gwagner@cdc.gov
U2 - PMID: 17382808.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hendeles, Leslie
AU - Colice, Gene L.
AU - Meyer, Robert J.
T1 - Withdrawal of Albuterol Inhalers Containing Chlorofluorocarbon Propellants.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2007/03/29/
VL - 356
IS - 13
M3 - Article
SP - 1344
EP - 1351
SN - 00284793
AB - The article discusses how albuterol, or salbutamol, metered-dose inhalers, used to treat bronchospasm symptoms in patients with asthma or chronic obstructive pulmonary disease are switching from using chlorofluorocarbon propellants to hydrofluoroalkane propellants. The mandatory switch from chlorofluorocarbon to hydrofluoroalkane propellants is due to public health concerns about the effects of chlorofluorocarbons on stratospheric ozone levels. Differences between chlorofluorocarbon and hydrofluoroalkane inhalers are discussed. The efficacy and safety of hydrofluoroalkane inhalers are discussed. Economic aspects of the mandated transition to hydrofluoroalkane inhalers are discussed.
KW - ALBUTEROL
KW - METERED-dose inhalers
KW - INHALERS
KW - RESPIRATORY therapy -- Equipment & supplies
KW - DRUG delivery devices
KW - ASTHMA -- Treatment
KW - OBSTRUCTIVE lung diseases -- Treatment
KW - CHLOROFLUOROCARBONS
N1 - Accession Number: 24585029; Hendeles, Leslie 1; Email Address: hendeles@cop.ufl.edu Colice, Gene L. 2 Meyer, Robert J. 3; Affiliation: 1: College of Pharmacy and the Pediatric Pulmonary Division, University of Florida, Gainesville 2: George Washington University School of Medicine and the Washington Hospital Center, Washington, DC 3: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 3/29/2007, Vol. 356 Issue 13, p1344; Subject Term: ALBUTEROL; Subject Term: METERED-dose inhalers; Subject Term: INHALERS; Subject Term: RESPIRATORY therapy -- Equipment & supplies; Subject Term: DRUG delivery devices; Subject Term: ASTHMA -- Treatment; Subject Term: OBSTRUCTIVE lung diseases -- Treatment; Subject Term: CHLOROFLUOROCARBONS; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 8p; Illustrations: 3 Black and White Photographs, 3 Charts; Document Type: Article; Full Text Word Count: 5225
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walker, Richard I.
AU - Steele, Duncan
AU - Aguado, Teresa
T1 - Analysis of strategies to successfully vaccinate infants in developing countries against enterotoxigenic E. coli (ETEC) disease
JO - Vaccine
JF - Vaccine
Y1 - 2007/03/30/
VL - 25
IS - 14
M3 - Article
SP - 2545
EP - 2566
SN - 0264410X
AB - Abstract: Enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause of diarrhoea in the world, annually affecting up to 400,000,000 children under 5 years of age living in developing countries (DCs). Although ETEC possesses numerous antigens, the relatively conserved colonization factor (CF) antigens and the heat labile enterotoxin (LT) have been associated with protection and most vaccine candidates have exploited these antigens. A safe and effective vaccine against ETEC is a feasible goal as supported by the acquisition of protective immunity. The success of an ETEC vaccine targeting infants and children in DCs will depend on a combination of maximally antigenic vaccine preparations and regimens for their delivery which will produce optimal immune responses to these antigens. Vaccine candidates having a high priority for accelerated development and clinical testing for eventual use in infants would include inactivated ETEC or Shigella hybrids expressing ETEC antigens as well as attenuated ETEC strains which express the major CF antigens and LT toxin B-subunit, as well as attenuated Shigella, Vibrio cholerae and Salmonella typhi hybrids engineered to deliver antigens of ETEC. Candidates for an ETEC vaccine would have to meet the minimal requirement of providing at least 50% protection against severe disease in DCs during the first 2 years of life. The critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded and focused effort to bring it to realization. However, a Product Development Partnership to overcome this hurdle could accelerate the time lines towards when control of ETEC disease in DCs is substantially closer. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Immune response
KW - Escherichia coli diseases
KW - Vaccination of children
KW - Vaccines
KW - Diarrhoeal disease
KW - Enterotoxigenic Escherichia coli
KW - Vaccine
N1 - Accession Number: 24387148; Walker, Richard I. 1; Email Address: walkerri@cber.fda.gov; Steele, Duncan 2; Aguado, Teresa 2; Affiliations: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20851-1448, USA; 2: IVR/BAC, Department of Immunization, Vaccines and Biologicals, World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland; Issue Info: Mar2007, Vol. 25 Issue 14, p2545; Thesaurus Term: VACCINATION; Thesaurus Term: Immune response; Subject Term: Escherichia coli diseases; Subject Term: Vaccination of children; Subject Term: Vaccines; Author-Supplied Keyword: Diarrhoeal disease; Author-Supplied Keyword: Enterotoxigenic Escherichia coli; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.12.028
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - van Houdt, Robin
AU - Sonder, Gerard J.B.
AU - Dukers, Nicole H.T.M.
AU - Bovee, Lian P.M.J.
AU - van den Hoek, Anneke
AU - Coutinho, Roel A.
AU - Bruisten, Sylvia M.
T1 - Impact of a targeted hepatitis B vaccination program in Amsterdam, The Netherlands
JO - Vaccine
JF - Vaccine
Y1 - 2007/03/30/
VL - 25
IS - 14
M3 - Article
SP - 2698
EP - 2705
SN - 0264410X
AB - Abstract: To evaluate hepatitis B virus (HBV) risk group vaccination in Amsterdam, which started in 1998, we examined 342 reported acute HBV-cases and sequenced 85 DNA isolates. The reported number of cases declined from 214 in 1992–1997 to 128 in 1998–2003, due to a decline in injecting drug users (IDU) and their heterosexual partners. Phylogenetic analyses showed that after 1998, the IDU cluster nearly disappeared, probably due to a decline in injecting. Acute HBV remained stable among men having sex with men; given their increased sexual risk behavior, vaccination has probably prevented an increase in their acute infections. Currently, 48–72% of the people who should be included in the program are still susceptible to HBV. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Molecular epidemiology
KW - Hepatitis B
KW - Amsterdam (Netherlands)
KW - Netherlands
KW - HBV
KW - Risk group vaccination
N1 - Accession Number: 24387164; van Houdt, Robin 1; Email Address: rvhoudt@ggd.amsterdam.nl; Sonder, Gerard J.B. 1; Dukers, Nicole H.T.M. 1,2; Bovee, Lian P.M.J. 1; van den Hoek, Anneke 1; Coutinho, Roel A. 2,3; Bruisten, Sylvia M. 1,2; Affiliations: 1: GGD, Public Health Service, Department of Infectious Diseases, Amsterdam, The Netherlands; 2: Amsterdam Medical Center, University of Amsterdam, Department of Human Retrovirology, Amsterdam, The Netherlands; 3: Center for Infectious Diseases, National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands; Issue Info: Mar2007, Vol. 25 Issue 14, p2698; Thesaurus Term: VACCINATION; Thesaurus Term: Molecular epidemiology; Subject Term: Hepatitis B; Subject: Amsterdam (Netherlands); Subject: Netherlands; Author-Supplied Keyword: HBV; Author-Supplied Keyword: Risk group vaccination; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.06.058
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vinicius C.S. Antao
AU - Chris A. Piacitelli
AU - William E. Miller
AU - Germania A. Pinheiro
AU - Kathleen Kreiss
T1 - Rayon Flock: A New Cause of Respiratory Morbidity in a Card Processing PlantThe findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.This article is a US government work and, as such, is in the public domain in the United States of America.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/04//
VL - 50
IS - 4
M3 - Article
SP - 274
EP - 284
SN - 02713586
AB - Following employee respiratory concerns, we investigated the health effects of rayon flock exposure at a card manufacturing plant.We conducted a cross‐sectional survey including environmental evaluation, standardized questionnaires, spirometry, carbon monoxide diffusing capacity testing, and methacholine challenge testing.From a total of 239 participants, 146 (61%) reported working at least 1 hr per week in areas where flock‐coated cards are processed (“flock workers”) and 47 (20%) reported cleaning equipment with compressed air. These workers had generally higher prevalences of respiratory symptoms. Flock workers and employees with longer tenure at areas where flock‐coated cards are processed were more likely to have restrictive impairment of lung function. Although dust and fiber samples were largely below the detection limits, peak exposures to airborne particulate occurred during cleaning with compressed air.Working with rayon flock and cleaning with compressed air were associated with health effects in workers at this plant. Am. J. Ind. Med. Published 2007 Wiley‐Liss, Inc [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health
KW - Factories
KW - Respiratory diseases
KW - Employees -- Rating of
N1 - Accession Number: 25509229; Vinicius C.S. Antao 1; Chris A. Piacitelli 1; William E. Miller 1; Germania A. Pinheiro 1; Kathleen Kreiss 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Apr2007, Vol. 50 Issue 4, p274; Thesaurus Term: Health; Thesaurus Term: Factories; Subject Term: Respiratory diseases; Subject Term: Employees -- Rating of; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Guang X. Chen
AU - E. Lynn Jenkins
T1 - Potential work‐related exposures to bloodborne pathogens by industry and occupation in the United States Part II: A telephone interview studyThis article is a US government work and, as such, is in the public domain in the United States of America.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/04//
VL - 50
IS - 4
M3 - Article
SP - 285
EP - 292
SN - 02713586
AB - The companion surveillance portion of this study [Chen and Jenkins, 2007] reported the frequency and rate of potential work‐related exposures to bloodborne pathogens (BBP) treated in emergency departments (EDs) by industry and occupation, but it lacks details on the circumstances of the exposure and other relevant issues such as BBP safety training, use of personal protective equipment (PPE) or safety needles, or reasons for seeking treatment in a hospital ED.Telephone interviews were conducted with workers who had been treated in EDs for potential work‐related exposures to BBP in 2000–2002. Respondents were drawn from the National Electronic Injury Surveillance System.Of the 593 interviews, 382 were from hospitals, 51 were from emergency medical service/firefighting (EMS/FF), 86 were from non‐hospital healthcare settings (e.g., nursing homes, doctors' offices, home healthcare providers, etc.), 22 were from law enforcement (including police and correctional facilities), and 52 were from other non‐healthcare settings (i.e., schools, hotels, and restaurants). Needlestick/sharps injuries were the primary source of exposure in hospitals and non‐hospital healthcare settings. Skin and mucous membrane was the primary route of exposure in EMS/FF. Human bites accounted for a significant portion of the exposures in law enforcement and other non‐healthcare settings. In general, workers from non‐hospital settings were less likely to use PPE, to have BBP safety training, to be aware of the BBP standards and exposure treatment procedures, and to report or seek treatment for a work‐related exposure compared to hospital workers.This study suggests that each industry group has unique needs that should be addressed. Am. J. Ind. Med. 2007. Published 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic microorganisms
KW - Bloodborne infections
KW - Trade regulation
KW - Medical emergencies
N1 - Accession Number: 25509230; Guang X. Chen 1; E. Lynn Jenkins 2; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia; 2: National Institute for Occupational Safety and Health, Research to Practice, Morgantown, West Virginia; Issue Info: Apr2007, Vol. 50 Issue 4, p285; Thesaurus Term: Pathogenic microorganisms; Subject Term: Bloodborne infections; Subject Term: Trade regulation; Subject Term: Medical emergencies; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee C. Yong
AU - Paul A. Schulte
AU - Chi‐Yu Kao
AU - Roger W. Giese
AU - Mark F. Boeniger
AU - Gary H.S. Strauss
AU - Martin R. Petersen
AU - John K. Wiencke
T1 - DNA adducts in granulocytes of hospital workers exposed to ethylene oxideThe findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/04//
VL - 50
IS - 4
M3 - Article
SP - 293
EP - 302
SN - 02713586
AB - Ethylene oxide (EtO), an important industrial chemical intermediate and sterilant, is classified as a human carcinogen. Occupational EtO exposure in many countries is regulated at 1 ppm (8‐hr TWA), but levels of EtO‐DNA adducts in humans with low occupational EtO exposures have not been reported.We examined the formation of N7‐(2′‐hydroxyethyl)guanine (N7‐HEG), a major DNA adduct of EtO, in 58 EtO‐exposed sterilizer operators and six nonexposed workers from ten hospitals. N7‐HEG was quantified in granulocyte DNA (0.1–11.5 µg) by a highly sensitive and specific gas chromatography‐electron capture‐mass spectrometry method. Cumulative exposure to EtO (ppm‐hour) was estimated during the 4‐month period before the collection of blood samples.There was considerable inter‐individual variability in the levels of N7‐HEG with a range of 1.6–241.3 adducts/107 nucleotides. The mean levels in the nonexposed, low (≤32 ppm‐hour), and high (>32 ppm‐hour) EtO‐exposure groups were 3.8, 16.3, and 20.3 adducts/107 nucleotides, respectively, after the adjustment for cigarette smoking and other potential confounders, but the differences were not statistically significant.This study has demonstrated for the first time, detectable levels of N7‐HEG adducts in granulocytes of hospital workers with EtO exposures at levels less than the current U.S. standard of 1 ppm (8‐hr TWA). A nonsignificant increase in adduct levels with increasing EtO exposure indicates that further studies of EtO‐exposed workers are needed to clarify the relationship between EtO exposure and N7‐HEG adduct formation. Am. J. Ind. Med. 2007. © 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA adducts
KW - Granulocytes
KW - Hospital personnel
KW - Ethylene oxide
N1 - Accession Number: 25509232; Lee C. Yong 1; Paul A. Schulte 2; Chi‐Yu Kao 3; Roger W. Giese 3; Mark F. Boeniger 1; Gary H.S. Strauss 4; Martin R. Petersen 1; John K. Wiencke 5; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio; 2: Education and Information Division, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio; 3: Department of Pharmaceutical Sciences and Barnett Institute, Northeastern University, Boston, Massachusetts; 4: Pb2Au Biomedical Technology Assessment & Development, Chapel Hill, North Carolina; 5: Neuro and Molecular Epidemiology Laboratory, University of California, San Francisco, California; Issue Info: Apr2007, Vol. 50 Issue 4, p293; Subject Term: DNA adducts; Subject Term: Granulocytes; Subject Term: Hospital personnel; Subject Term: Ethylene oxide; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scott A. Hendricks
AU - E. Lynn Jenkins
AU - Kristi R. Anderson
T1 - Trends in workplace homicides in the U.S., 1993–2002: A decade of declineThe findings and conclusions in this report are those of the authors and do not necessarily represent the view of the National Institute for Occupational Safety and Health.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/04//
VL - 50
IS - 4
M3 - Article
SP - 316
EP - 325
SN - 02713586
AB - Trends in workplace homicide rates are compared to the trends in U.S. homicides from 1993 to 2002, inclusively. The homogeneity of workplace homicide rates by victim demographics, circumstances, and types of events are also addressed.Using publicly available data from several sources, Poisson models are used to statistically compare the trends of workplace homicide rates versus U.S. homicide rates and to compare trends within categories of workplace homicides.Overall, there was a significant decline in the rates of occupational homicide of approximately 6% per year during the study time period; this decline was found to be statistically greater than the decline of all U.S. homicides (5% per year). Taxi cab drivers and chauffeurs demonstrated the greatest decline of all occupational subgroups. When looking at the circumstances of workplace homicides, only the rate of homicides committed during a robbery or other crime demonstrated a significant decline.While workplace homicides have declined in the U.S., the declines have not occurred uniformly across demographic and occupational categories. Am. J. Ind. Med. 2007. © 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Work-related injuries
KW - Homicide
KW - Homogeneity
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 25509231; Scott A. Hendricks 1; E. Lynn Jenkins 2; Kristi R. Anderson 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, West Virginia; 2: National Institute for Occupational Safety and Health, Office of Research and Technology Transfer, Morgantown, West Virginia; Issue Info: Apr2007, Vol. 50 Issue 4, p316; Subject Term: Work-related injuries; Subject Term: Homicide; Subject Term: Homogeneity ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Feldman, Irv
AU - Feldman, Gerald M.
AU - Mobarak, Charlotte
AU - Dunkelberg, Jeffrey C.
AU - Leslie, Kimberly K.
T1 - Identification of proteins within the nuclear factor-κ B transcriptional complex including estrogen receptor-α
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2007/04//
VL - 196
IS - 4
M3 - Article
SP - 394
EP - 394
SN - 00029378
AB - Objective: The objective of the study was to determine whether cross-talk occurs between estrogen receptors (ERs) and nuclear factor-kappa-B (NF-κB), to assess the functional consequences of such an ER/NF-κB interaction, and to identify other unknown regulatory proteins that may participate in the NF-κB transcriptional complex. Study Design: Electromobility gel shifts, reporter gene assays, and mass spectrometry were used to identify proteins interacting with the NF-κB deoxyribonucleic acid (DNA) response element. Results: ER and the p65 subunit of NF-κB colocalized on DNA. This interaction was inhibitory for ER transcriptional activity. Sequencing of proteins bound to the NF-κB/DNA complex identified DNA-modifying enzymes, scaffolding proteins, chaperones, and elements of the nuclear matrix. Conclusion: These studies have identified an inhibitory interaction between estrogen receptors and the p65 subunit of NF-κB with implications for estrogen action in pregnancy and cancer. New accessory proteins have also been identified that bind to protein complexes on the NF-κB DNA response element. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTROGEN receptors
KW - NF-kappa B (DNA-binding protein)
KW - PROTEINS
KW - DNA
KW - MOLECULAR chaperones
KW - PREGNANCY
KW - CANCER
KW - Apoptosis
KW - endometrial cancer
KW - HTR8/SVneo cells
KW - infection
KW - inflammation
KW - Ishikawa cells
KW - placenta
KW - preterm labor
KW - trophoblast
N1 - Accession Number: 24553588; Feldman, Irv 1; Feldman, Gerald M. 2; Mobarak, Charlotte 3,4; Dunkelberg, Jeffrey C. 5; Leslie, Kimberly K. 3,4,6,7; Email Address: kleslie@salud.unm.edu; Source Information: Apr2007, Vol. 196 Issue 4, p394; Subject: ESTROGEN receptors; Subject: NF-kappa B (DNA-binding protein); Subject: PROTEINS; Subject: DNA; Subject: MOLECULAR chaperones; Subject: PREGNANCY; Subject: CANCER; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: endometrial cancer; Author-Supplied Keyword: HTR8/SVneo cells; Author-Supplied Keyword: infection; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: Ishikawa cells; Author-Supplied Keyword: placenta; Author-Supplied Keyword: preterm labor; Author-Supplied Keyword: trophoblast; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2006.12.033
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Stefanaiak, Aleksandr B.
AU - Brink, Christopher A.
AU - Dickerson, Robert M.
AU - Day, Gregory A.
AU - Brisson, Michael J.
AU - Hoover, Mark D.
AU - Scripsick, Ronald C.
T1 - A theoretical framework for evaluating analytical digestion methods for poorly soluble particulate beryllium.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/04//
VL - 387
IS - 7
M3 - Article
SP - 2411
EP - 2417
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Complete digestion of all chemical forms and sizes of particulate analytes in environmental samples is usually necessary to obtain accurate results with atomic spectroscopy. In the current study, we investigate the physicochemical properties of beryllium particles likely to be encountered in samples collected from different occupational environments and present a hypothesis that a dissolution theory can be used as a conceptual framework to guide development of strategies for digestion procedures. For monodisperse single-chemical constituent primary particles, such as those encountered when handling some types of beryllium oxide (BeO) powder, theory predicts that a digestion procedure is sufficient when it completely dissolves all primary particles, independent of cluster size. For polydisperse single-chemical constituent particles, such as those encountered during the handling of some types of beryllium metal powder, theory predicts that a digestion procedure is sufficient only when it completely dissolves the largest particle in the sample. For samples with unknown or multi-chemical constituent particles and with particles having undefined sizes, e.g., fume emissions from a copper–beryllium alloy furnace operation or dust from a beryl ore crushing operation, a surface area-limited and single-constituent-dependent dissolution theory may not predict complete dissolution, thereby requiring non-routine robust treatment procedures with post-digestion filtration, followed by examination of residual particulate material. Additionally, for beryllium, and likely other poorly soluble materials, particulate reference materials of various chemical forms and size distributions are needed to better evaluate and harmonize analytical digestion procedures. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIGESTION
KW - PARTICULATE matter
KW - ATOMIC spectroscopy
KW - BERYLLIUM
KW - EMISSIONS (Air pollution)
KW - Analytical methods
KW - Beryllium compounds
KW - Quantitative analysis
N1 - Accession Number: 24259178; Stefanaiak, Aleksandr B. 1; Email Address: AStefaniak@cdc.gov Brink, Christopher A. 2 Dickerson, Robert M. 2 Day, Gregory A. 1 Brisson, Michael J. 3 Hoover, Mark D. 1 Scripsick, Ronald C. 2; Affiliation: 1: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Los Alamos National Laboratory, Los Alamos, NM 87545, USA 3: Washington Savannah River Company, Savannah River Site, Aiken, SC 29808, USA; Source Info: Apr2007, Vol. 387 Issue 7, p2411; Subject Term: DIGESTION; Subject Term: PARTICULATE matter; Subject Term: ATOMIC spectroscopy; Subject Term: BERYLLIUM; Subject Term: EMISSIONS (Air pollution); Author-Supplied Keyword: Analytical methods; Author-Supplied Keyword: Beryllium compounds; Author-Supplied Keyword: Quantitative analysis; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 1 Chart; Document Type: Article
L3 - 10.1007/s00216-006-0928-x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - RAHAMIMOFF, H.
AU - ELBAZ, B.
AU - ALPEROVICH, A.
AU - KIMCHI-SARFATY, C.
AU - GOTTESMAN, M. M.
AU - LICHTENSTEIN, Y.
AU - ESKIN-SHWARTZ, M.
AU - KASIR, J.
T1 - Cyclosporin A-Dependent Downregulation of the Na+/Ca2+ Exchanger Expression.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2007/04//
VL - 1099
M3 - Article
SP - 204
EP - 214
SN - 00778923
AB - Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and many nonexcitable tissues. Three genes, NCX1, NCX2, and NCX3 code for Na+/Ca2+ exchange activity. NCX1 gene products are the most abundant. We have shown previously that exposure of NCX1-transfected HEK 293 cells to CsA, leads to concentration-dependent reduction of Na+/Ca2+ exchange activity and surface expression, without a reduction in total cell-expressed NCX1 protein. We show now that the effect of CsA on NCX1 protein expression is not restricted to transfected cells overexpressing the NCX1 protein but exhibited also in cells expressing endogenously the NCX1 protein (L6, H9c2, and primary smooth muscle cells). Exposure of NCX2- and NCX3-transfected cells to CsA results also in reduction of Na+/Ca2+ exchange activity and surface expression, though the sensitivity to the drug was lower than in NCX1-transfected cells. Studying the molecular mechanism of CsA–NCX interaction suggests that cyclophilin (Cyp) is involved in NCX1 protein expression and its modulation by CsA. Deletion of 426 amino acids from the large cytoplasmic loop of the protein retains the CsA-dependent downregulation of the truncated NCX1 suggesting that CsA–Cyp–NCX interaction involves the remaining protein domains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOSPORINE
KW - IMMUNOSUPPRESSIVE agents
KW - HYPERTENSION
KW - NEPHROTOXICOLOGY
KW - SODIUM
KW - CALCIUM
KW - MUTAGENESIS
KW - BODY fluids -- Analysis
KW - cyclophilin A
KW - cyclosporin A
KW - Na+/Ca2+ exchanger expression
KW - proline mutagenesis
N1 - Accession Number: 24998074; RAHAMIMOFF, H. 1,2; Email Address: Hannah.Rahamimoff@huji.ac.il ELBAZ, B. 1,2 ALPEROVICH, A. 1 KIMCHI-SARFATY, C. 2,3 GOTTESMAN, M. M. 2 LICHTENSTEIN, Y. 1 ESKIN-SHWARTZ, M. 1 KASIR, J. 1; Affiliation: 1: Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, 91120 Israel 2: Laboratory of Cell Biology, NCI, NIH, Bethesda, Maryland 20892, USA 3: Division of Hematology, Food and Drug Administration, Bethesda, Maryland 20892, USA; Source Info: 2007, Vol. 1099, p204; Subject Term: CYCLOSPORINE; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: HYPERTENSION; Subject Term: NEPHROTOXICOLOGY; Subject Term: SODIUM; Subject Term: CALCIUM; Subject Term: MUTAGENESIS; Subject Term: BODY fluids -- Analysis; Author-Supplied Keyword: cyclophilin A; Author-Supplied Keyword: cyclosporin A; Author-Supplied Keyword: Na+/Ca2+ exchanger expression; Author-Supplied Keyword: proline mutagenesis; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 1 Diagram, 5 Graphs; Document Type: Article
L3 - 10.1196/annals.1387.046
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kreiss, Kathleen
AU - Day, Gregory A.
AU - Schuler, Christine R.
T1 - Beryllium: A Modern Industrial Hazard.
JO - Annual Review of Public Health
JF - Annual Review of Public Health
Y1 - 2007/04//
VL - 28
IS - 1
M3 - Article
SP - 259
EP - 277
SN - 01637525
AB - Beryllium exposure can cause a granulomatous lung disease in workers who develop a lymphocyte-mediated sensitization to the metal. Workers in diverse industries are at risk because beryllium's properties are critical to nuclear, aerospace, telecommunications, electronic, metal alloy, biomedical, and semiconductor industries. The occupational air concentration standard's failure to protect beryllium workers is driving many scientific and occupational health advances. These developments include study of bioavailability of different physicochemical forms of beryllium, medical surveillance to show effectiveness of skin protection in preventing sensitization in high-risk processes, gene-environment interaction, transgenic mice for use in experimental research, and risk-based management of industrial exposures in the absence of effective exposure-response information. Beryllium sensitization and disease prevention are paradigms for much broader public health action in both occupational and general population settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annual Review of Public Health is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BERYLLIUM
KW - LUNG diseases
KW - LYMPHOCYTES
KW - OCCUPATIONAL diseases
KW - GENOTYPE-environment interaction
KW - TRANSGENIC mice
KW - MICE as laboratory animals
KW - berylliosis
KW - dermal exposure
KW - genetics
KW - sensitization
N1 - Accession Number: 25077735; Kreiss, Kathleen 1; Email Address: kkreiss@cdc.gov Day, Gregory A. 1; Email Address: gday@cdc.gov Schuler, Christine R. 1; Email Address: cschuIer@cdc.gov; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: 2007, Vol. 28 Issue 1, p259; Subject Term: BERYLLIUM; Subject Term: LUNG diseases; Subject Term: LYMPHOCYTES; Subject Term: OCCUPATIONAL diseases; Subject Term: GENOTYPE-environment interaction; Subject Term: TRANSGENIC mice; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: berylliosis; Author-Supplied Keyword: dermal exposure; Author-Supplied Keyword: genetics; Author-Supplied Keyword: sensitization; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 19p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1146/annurev.publhealth.28.021406.114011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leggat, Peter A.
AU - Smith, Derek R.
AU - Kedjarune, Ureporn
T1 - SURGICAL APPLICATIONS OF CYANOACRYLATE ADHESIVES: A REVIEW OF TOXICITY.
JO - ANZ Journal of Surgery
JF - ANZ Journal of Surgery
Y1 - 2007/04//
VL - 77
IS - 4
M3 - Article
SP - 209
EP - 213
PB - Wiley-Blackwell
SN - 14451433
AB - Cyanoacrylate (CA) and its homologues have a variety of medical and commercial applications as biological adhesives and sealants. Homologues of CA are being widely promoted in surgery as a tissue adhesive to replace traditional suturing techniques. Potential benefits of using CA adhesives include better cosmetic results, more rapid wound closure, and perhaps most significantly, the potential for significant reductions in percutaneous injuries from suture needles, which would in turn also reduce the risk of transmission of infectious diseases. Nevertheless, certain concerns have been raised regarding the potential toxicity of CA within patients, as well as among health professionals who are occupationally exposed when using CA compounds. Reported toxicity of CA in the workplace may result in dermatological, allergic and respiratory conditions. To help reduce the occupational burden, therefore, medical staff using CA adhesives should avoid direct contact with the compound and use appropriate personal protective measures at all times. Maintaining higher levels of humidity, optimizing room ventilation and using special air conditioning filters in surgical suites and operating theatres may also be useful in minimizing the exposure to volatile CA adhesives. [ABSTRACT FROM AUTHOR]
AB - Copyright of ANZ Journal of Surgery is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYANOACRYLATES
KW - ALLERGY
KW - ASTHMA
KW - SKIN diseases
KW - SURGERY
KW - cyanoacrylate
KW - medical
KW - occupational allergy
KW - occupational asthma
KW - occupational skin disease
KW - surgery
KW - toxic effect
N1 - Accession Number: 24312416; Leggat, Peter A. 1; Email Address: peter.leggat@jcu.edu.au Smith, Derek R. 1,2 Kedjarune, Ureporn 3; Affiliation: 1: Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Queensland, Australia 2: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan 3: Department of Oral Biology and Occlusion, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Thailand; Source Info: Apr2007, Vol. 77 Issue 4, p209; Subject Term: CYANOACRYLATES; Subject Term: ALLERGY; Subject Term: ASTHMA; Subject Term: SKIN diseases; Subject Term: SURGERY; Author-Supplied Keyword: cyanoacrylate; Author-Supplied Keyword: medical; Author-Supplied Keyword: occupational allergy; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: occupational skin disease; Author-Supplied Keyword: surgery; Author-Supplied Keyword: toxic effect; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1445-2197.2007.04020.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pyoung Il Kim
AU - Min Young Jung
AU - Young-Hyo Chang
AU - Saehun Kim
AU - Seong-Jae Kim
AU - Yong-Ha Park
T1 - Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2007/04//
VL - 74
IS - 5
M3 - Article
SP - 1103
EP - 1111
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - One strain of Lactobacillus salivarius, two strains of Lactobacillus reuteri and Lactobacillus amylovorus, and two strains of Bifidobacterium thermacidophilum with antagonistic effect against Clostridium perfringens were isolated from porcine gastrointestinal tract. Isolates were assayed for their ability to survive in synthetic gastric juice at pH 2.5 and were examined for their ability to grow on agar plate containing porcine bile extract. There was a large variation in the survival of the isolates in gastric juice and growth in the medium containing 0.3% ( w/ v) bile. L. salivarius G11 and L. amylovorus S6 adhered to the HT-29 epithelial cell line. Cell-free supernatant of L. amylovorus S6 showed higher antagonistic activity as effective as the antibiotics such as neomycin, chlortetracycline, and oxytetracycline against bacterial pathogens including C. perfringens, Salmonella typhimurium, Staphylococcus aureus, Vibrio cholerae, Edwardsiella tarda, and Aeromonas salmonicida subsp. salmonicida. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LACTOBACILLUS
KW - BIFIDOBACTERIUM bifidum
KW - CLOSTRIDIUM
KW - CELL lines
KW - ANTIBIOTICS
KW - PATHOGENIC microorganisms
KW - Antagonistic effect
KW - Bifidobacterium thermacidophilum
KW - Clostridium perfringens
KW - Lactobacillus amylovorus
KW - Lactobacillus reuteri
KW - Lactobacillus salivarius
N1 - Accession Number: 24398740; Pyoung Il Kim 1 Min Young Jung 1 Young-Hyo Chang 1 Saehun Kim 2 Seong-Jae Kim 3 Yong-Ha Park 4; Email Address: peter@yumail.ac.kr; Affiliation: 1: Korea Research Institute of Bioscience and Biotechnology, 52 Oeundong, Yusong, Daejeon 305-333, South Korea 2: Division of Food Science, Korea University, 5-1 Anam-dong, Sungbuk-ku, Seoul, South Korea 3: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA 4: Department of Applied Microbiology, Yeungnam University, Gyeongsan, South Korea; Source Info: Apr2007, Vol. 74 Issue 5, p1103; Subject Term: LACTOBACILLUS; Subject Term: BIFIDOBACTERIUM bifidum; Subject Term: CLOSTRIDIUM; Subject Term: CELL lines; Subject Term: ANTIBIOTICS; Subject Term: PATHOGENIC microorganisms; Author-Supplied Keyword: Antagonistic effect; Author-Supplied Keyword: Bifidobacterium thermacidophilum; Author-Supplied Keyword: Clostridium perfringens; Author-Supplied Keyword: Lactobacillus amylovorus; Author-Supplied Keyword: Lactobacillus reuteri; Author-Supplied Keyword: Lactobacillus salivarius; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 9p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00253-006-0741-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Priest, P.
AU - Sadler, L.
AU - Peters, J.
AU - Crengle, S.
AU - Bethwaite, P.
AU - Medley, G.
AU - Jackson, R.
T1 - Pathways to diagnosis of cervical cancer: screening history, delay in follow up, and smear reading.
JO - BJOG: An International Journal of Obstetrics & Gynaecology
JF - BJOG: An International Journal of Obstetrics & Gynaecology
Y1 - 2007/04//
VL - 114
IS - 4
M3 - Article
SP - 398
EP - 407
SN - 14700328
AB - Background The aim of this study was to determine the most important ways to reduce incidence of and mortality from cervical cancer by a nationally co-ordinated screening programme. Design Descriptive study. Setting The New Zealand National Cervical Screening Programme: a nationally organised and co-ordinated programme. Sample Women aged younger than 80 years with histologically proven primary invasive cervical cancer, including microinvasive disease, diagnosed between 1 January 2000 and 30 September 2002. Consent for access to medical records was gained for 371 of 445 eligible women (83%). A total of 359 (81%) of eligible women or their next of kin consented to interview. Methods Data on events prior to diagnosis were obtained from routine sources, interview, medical record review and slide reread. Main outcome measures Frequency of screening in the 7 years prior to diagnosis, time from abnormal smear or symptoms to appropriate diagnostic confirmation, proportion of negative smears upgraded to high grade on reread. Results Half of the 371 participants (83% of 445 eligible women) had not had a screening smear in the 3 years prior to diagnosis, and 80% were defined as inadequately screened. A maximum of 17% of women overall or within any defined subgroup experienced delays in follow up of abnormal smears or bleeding. Only 11% of women overall had had a high-grade smear, which was originally read as negative. Conclusions The most important factor in women’s pathways to a diagnosis of cervical cancer was inadequate screening. While delays in diagnosis could be reduced and laboratory performance improved, priority must be given to improving uptake and frequency of screening. [ABSTRACT FROM AUTHOR]
AB - Copyright of BJOG: An International Journal of Obstetrics & Gynaecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CERVICAL cancer -- Diagnosis
KW - PAP test
KW - CANCER -- Mortality
KW - CANCER in women
KW - NEW Zealand
KW - Cervical cancer
KW - cervical screening
KW - Pap smear
KW - screening programmes
N1 - Accession Number: 24271051; Priest, P. 1; Email Address: patricia.priest@otago.ac.nz Sadler, L. 1 Peters, J. 2 Crengle, S. 3 Bethwaite, P. 4 Medley, G. 5 Jackson, R. 1; Affiliation: 1: Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand 2: Auckland Regional Public Health Service, Auckland District Health Board, Auckland, New Zealand 3: Te Kupenga Hauora Mäori Department of Mäori Health, School of Population Health, University of Auckland, Auckland, New Zealand 4: Department of Pathology and Molecular Medicine, Wellington School of Medicine, Wellington South, New Zealand 5: Melbourne Pathology, Collingwood, Victoria, Australia; Source Info: Apr2007, Vol. 114 Issue 4, p398; Subject Term: CERVICAL cancer -- Diagnosis; Subject Term: PAP test; Subject Term: CANCER -- Mortality; Subject Term: CANCER in women; Subject Term: NEW Zealand; Author-Supplied Keyword: Cervical cancer; Author-Supplied Keyword: cervical screening; Author-Supplied Keyword: Pap smear; Author-Supplied Keyword: screening programmes; Number of Pages: 10p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1471-0528.2006.01207.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yao, Yong-Mei
AU - Cao, Wei
AU - Cao, Ya-Jie
AU - Cheng, Ze-Neng
AU - Ou-Yang, Dong-Sheng
AU - Liu, Zhao-Qian
AU - Zhou, Hong-Hao
T1 - Effect of sinomenine on human cytochrome P450 activity
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 2007/04//
VL - 379
IS - 1/2
M3 - Article
SP - 113
EP - 118
SN - 00098981
AB - Abstract: Background: Cytochrome P450s superfamily expressed widely in organisms are known to play an important role in the biotransformation of many endogenous and exogenous substances. Inhibition or induction of cytochrome P450 isozymes is one of the major causes for clinical drug–drug interactions. Sinomenine can be metabolized to at least 2 metabolites in human, rat in vivo and in human liver microsomes. The major metabolite was identified to be N-demethylsinomenine. However, which CYP450 isozymes mediated by sinomenine in vivo and in vitro is not known. Method: In vitro study, 6 probe drugs were incubated with or without sinomenine respectively to study the effect of sinomenine on different cytochrome P450s activities in human microsomes. In vivo study, a 5-drug cocktail approach was used to study the inhibitive and inducing effect of sinomenine at normal clinical dose on cytochrome P450s activities. Results: Sinomenine (50 μmol/l) had no significant effects on the activities of CYP1A2, CYP3A4, CYP2C9, CYP2E1, and CYP2D6, but it decreased the activity of CYP2C19 by 69% (p =0.012) in human microsomes. In vivo, sinomenine showed almost no significant effects on the activities of CYP1A2, CYP3A4, CYP2E1, and CYP2D6, but enhanced the elimination of mephenytoin by 73% (p =0.032). Conclusion: Sinomenine (50 μmol/l) inhibited the activity of CYP2C19 in human microsomes, but in vivo sinomenine at normal clinical dose enhanced the elimination of mephenytoin. [Copyright &y& Elsevier]
AB - Copyright of Clinica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450
KW - CYTOCHROMES
KW - BIOTRANSFORMATION (Metabolism)
KW - BILIARY tract
KW - Cytochrome P450
KW - Induce
KW - Inhibit
KW - Sinomenine
N1 - Accession Number: 24302334; Yao, Yong-Mei 1 Cao, Wei 2 Cao, Ya-Jie 2 Cheng, Ze-Neng 2 Ou-Yang, Dong-Sheng 3 Liu, Zhao-Qian 3 Zhou, Hong-Hao 3; Email Address: hhzhou@public.cs.hn.cn; Affiliation: 1: Hunan Food and Drug Administration, Changsha, Hunan 410013, PR China 2: School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, PR China 3: Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Xiang-Ya School of Medicine, Central South University, Changsha, Hunan 410078, PR China; Source Info: Apr2007, Vol. 379 Issue 1/2, p113; Subject Term: CYTOCHROME P-450; Subject Term: CYTOCHROMES; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: BILIARY tract; Author-Supplied Keyword: Cytochrome P450; Author-Supplied Keyword: Induce; Author-Supplied Keyword: Inhibit; Author-Supplied Keyword: Sinomenine; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.cca.2006.12.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Etherton, John R.
AU - Ronaghi, Mahmood
AU - Current, Richard S.
T1 - Development of a pultruded FRP composite material ROPS for farm tractors
JO - Composite Structures
JF - Composite Structures
Y1 - 2007/04//
VL - 78
IS - 2
M3 - Article
SP - 162
EP - 169
SN - 02638223
AB - Abstract: The goal of this research was to explore the feasibility of fabricating a fixed-structure ROPS (rollover protective structure) for farm tractors from an FRP (fiberglass reinforced plastic) composite material. Evaluating the strength of proposed joint designs for the base and the upper corners of the FRP ROPS was the focus of this study. Three factors were investigated: base fixture strength for connecting the ROPS to the tractor, upper corner fastening strength, and FRP failure mechanisms under static loading. Results indicate the need for a well-bolted mounting connection. Also, the failure modes at bolted upper corners of an FRP ROPS were related to where bolt holes are located. Additionally, long cantilever beams similar to the vertical members of a ROPS absorbed energy well without significant lengthwise fiber failure. Failures observed were only at the base, rather than in the localized matrix failure that occurs at the loading point of shorter beams. When the full ROPS was loaded to failure, it exhibited three shear breakthroughs of matrix material at bolt holes before reaching its ultimate load strength at 53,370N (12,000lbf). An ultimate performance comparison to be evaluated is whether an FRP ROPS has equal or better impact energy absorption performance than a steel ROPS and whether it deflects no further than a steel ROPS element with an acceptable amount of deformation. Damage tolerance that takes into account changes in strength of an FRP ROPS due to tools and other objects striking it must be considered. With appropriate impact characteristics factored into a design, the value of FRP composites for ROPS is expected to reside in longevity and lower manufacturing costs. [Copyright &y& Elsevier]
AB - Copyright of Composite Structures is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPOSITE materials
KW - FARM tractors
KW - AGRICULTURAL equipment
KW - GLASS fibers
KW - Agriculture
KW - Fiberglass reinforced plastic
KW - ROPS
KW - Testing
N1 - Accession Number: 23352796; Etherton, John R. 1 Ronaghi, Mahmood 1 Current, Richard S.; Email Address: rcurrent@cdc.gov; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Apr2007, Vol. 78 Issue 2, p162; Subject Term: COMPOSITE materials; Subject Term: FARM tractors; Subject Term: AGRICULTURAL equipment; Subject Term: GLASS fibers; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: Fiberglass reinforced plastic; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: Testing; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 327993 Mineral Wool Manufacturing; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 326193 Motor vehicle plastic parts manufacturing; NAICS/Industry Codes: 327212 Other Pressed and Blown Glass and Glassware Manufacturing; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.compstruct.2005.08.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shuowei Cai
AU - Bal Ram Singh
AU - Sharma, Shashi
T1 - Botulism Diagnostics: From Clinical Symptoms to in vitro Assays.
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
Y1 - 2007/04//Apr-Jun2007
VL - 33
IS - 2
M3 - Article
SP - 109
EP - 125
PB - Taylor & Francis Ltd
SN - 1040841X
AB - Botulinum neurotoxin (BoNT), which cause the deadly neuroparalytic disease, botulism, is the most toxic substance known to man. BoNT can be used as potential bioterrorism agents, and therefore, pose great threat to national security and public health. Rapid and sensitive detection of BoNTs using molecular and biochemical techniques is an essential component in the diagnosis of botulism, and is yet to be achieved. The most sensitive and widely accepted assay method for BoNTs is mouse bioassay, which takes 4 days to complete. This clearly can not meet the need for clinical diagnosis of botulism, botulinum detection in field conditions, and screening of large scale samples. Consequently, the clinical diagnosis of botulism relies on the clinical symptom development, thus limiting the effectiveness of antitoxin treatment. In response to this critical need, many in vitro methods for BoNT detection are under development. This review is focused on recently developed in vitro detection methods for BoNTs, and emerging new technologies with potential for sensitive and rapid in vitro diagnostics for botulism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Microbiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Botulism
KW - Mice
KW - Biological assay
KW - Mass spectrometry
KW - Bacterial toxins
KW - Botulinum toxin
KW - Polymerase chain reaction
KW - Biosensors
KW - Nanoparticles
KW - Aptamer
KW - Biosensor
KW - Botulinum Neurotoxin
KW - Diagnostics
KW - Electrochemiluminescence
KW - ELISA
KW - Endopoeptidase Activity Assay
KW - Immuno-Polymerase Chain Reaction
KW - Lateral Flow Test
KW - Mass Spectrometry
KW - Mouse Bioassay
KW - Nanoparticle
KW - Protein Microarray
KW - Rolling Circle Amplification
N1 - Accession Number: 25346438; Shuowei Cai 1; Email Address: scai@umassd.edu; Bal Ram Singh 1; Sharma, Shashi 2; Affiliations: 1: Botulinum Research Center, and Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration College Park, Maryland; Issue Info: Apr-Jun2007, Vol. 33 Issue 2, p109; Thesaurus Term: Botulism; Thesaurus Term: Mice; Thesaurus Term: Biological assay; Thesaurus Term: Mass spectrometry; Thesaurus Term: Bacterial toxins; Subject Term: Botulinum toxin; Subject Term: Polymerase chain reaction; Subject Term: Biosensors; Subject Term: Nanoparticles; Author-Supplied Keyword: Aptamer; Author-Supplied Keyword: Biosensor; Author-Supplied Keyword: Botulinum Neurotoxin; Author-Supplied Keyword: Diagnostics; Author-Supplied Keyword: Electrochemiluminescence; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: Endopoeptidase Activity Assay; Author-Supplied Keyword: Immuno-Polymerase Chain Reaction; Author-Supplied Keyword: Lateral Flow Test; Author-Supplied Keyword: Mass Spectrometry; Author-Supplied Keyword: Mouse Bioassay; Author-Supplied Keyword: Nanoparticle; Author-Supplied Keyword: Protein Microarray; Author-Supplied Keyword: Rolling Circle Amplification; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 17p; Illustrations: 10 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1080/10408410701364562
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106128885
T1 - Work-exacerbated asthma.
AU - Henneberger PK
Y1 - 2007/04//2007 Apr
N1 - Accession Number: 106128885. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Public Health. NLM UID: 100936359.
KW - Asthma -- Epidemiology
KW - Occupational Diseases -- Epidemiology
KW - Asthma -- Diagnosis
KW - Asthma -- Immunology
KW - Asthma -- Prevention and Control
KW - Occupational Diseases -- Diagnosis
KW - Occupational Diseases -- Immunology
KW - Occupational Diseases -- Prevention and Control
KW - Occupational Exposure -- Adverse Effects
SP - 146
EP - 151
JO - Current Opinion in Allergy & Clinical Immunology
JF - Current Opinion in Allergy & Clinical Immunology
JA - CURR OPIN ALLERGY CLIN IMMUNOL
VL - 7
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE OF REVIEW: To summarize recent findings on work-exacerbated asthma, based on medical literature published during 2005 and the first 10 months of 2006. RECENT FINDINGS: Although prevalence estimates varied considerably among six recent epidemiologic studies, collectively they contribute to the conclusion that work-exacerbated asthma is common. Median work-exacerbated asthma prevalence estimates were 18% of adults with asthma, 25% of working adults with asthma and 45% of all work-related asthma cases. Work-exacerbated asthma can result from a variety of occupational triggers, including physical factors (e.g. extreme temperatures, exercise), behavioral states (e.g. strong emotions, stress), odors (e.g. perfume), general irritants and dust, and second-hand cigarette smoke. Work-exacerbated asthma cases have many of the same demographic and clinical traits as other adults with asthma and occupational asthma cases, although some differences have been reported. Recent review articles have offered some recommendations on the management of work-exacerbated asthma, but more comprehensive advice is anticipated from a professional medical society in the next few years. SUMMARY: Epidemiologic studies indicate that work-exacerbated asthma is common. Researchers have started to pay attention to work-exacerbated asthma, but more studies are needed on all aspects of this condition in order to improve diagnosis, management and prevention.
SN - 1528-4050
AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
U2 - PMID: 17351467.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106128884
T1 - Flavoring-related bronchiolitis obliterans.
AU - Kreiss K
Y1 - 2007/04//2007 Apr
N1 - Accession Number: 106128884. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Nutrition; Public Health. NLM UID: 100936359.
KW - Bronchiolitis Obliterans -- Chemically Induced
KW - Flavoring Agents -- Poisoning
KW - Ketones -- Poisoning
KW - Occupational Diseases -- Etiology
KW - Bronchiolitis Obliterans -- Epidemiology
KW - Butter
KW - Occupational Diseases -- Epidemiology
SP - 162
EP - 167
JO - Current Opinion in Allergy & Clinical Immunology
JF - Current Opinion in Allergy & Clinical Immunology
JA - CURR OPIN ALLERGY CLIN IMMUNOL
VL - 7
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE OF REVIEW: In 2000, inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Toxicologic and epidemiologic studies in the succeeding 5 years have intervention and research implications. RECENT FINDINGS: Irreversible obstructive disease exists in workers throughout the microwave popcorn industry, in flavoring manufacture, and in the chemical synthesis of diacetyl, a predominant chemical in butter flavoring. Biologic plausibility of the role of diacetyl and other components of butter flavoring in causing bronchiolitis obliterans exists in rodent experiments which demonstrate respiratory epithelial necrosis. Some risky jobs were associated with short-term peak flavoring exposures, and average 8-h diacetyl exposures as low as 0.02 parts per million were measured in a work area where disease occurred in workers mixing butter flavorings with heated oil. SUMMARY: Until safe levels of flavoring chemicals are determined, prevention requires substitution, engineering controls, improved work practices, and personal protective equipment to lower exposure, in conjunction with medical surveillance for accelerated declines in pulmonary function. An epidemiologic approach to longitudinal medical surveillance and flavoring chemical exposures, paired with inhalation toxicology studies of flavoring components, will lay the basis for determining health-protective exposure limits for various flavoring chemicals.
SN - 1528-4050
AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
U2 - PMID: 17351470.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lindsey, WB
AU - Lowdell, MW
AU - Marti, GE
AU - Abbasi, F.
AU - Zenger, V.
AU - King, KM
AU - Lamb Jr., LS
T1 - CD69 expression as an index of T-cell function: assay standardization, validation and use in monitoring immune recovery.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 2007/04//
VL - 9
IS - 2
M3 - Article
SP - 123
EP - 132
PB - Taylor & Francis Ltd
SN - 14653249
AB - Background CD69 is a surrogate marker of T-cell responsiveness to mitogen and Ag stimulus and can be used as a measure of T-lymphocyte activation. Quantitative flow cytometric determination of CD69 expression on T lymphocytes has several advantages over traditional lymphocyte proliferation assays, but this method has not yet been standardized for clinical applications. Methods We qualified a commercially available assay using the manufacturer's procedures for measurement of T-cell response to a mitogen (PHA), superantigen (Staphylococcus endotoxin B; SEB) and Ca2+ ionophore (phorbyl myristate acetate; PMA) with peripheral blood from healthy volunteers. Following this, we tested the usefulness of the assay in determining T-cell responses to PHA and SEB for six immunocompromised patients. Results Healthy volunteers showed 17-fold increases in T-cell CD69 Ab bound per cell (ABC) with PHA stimulation compared with the baseline. SEB was also an effective T-cell activating agent, increasing CD69 ABC by 5-fold, comparable with results obtained with PMA stimulation. PHA- and SEB-stimulated T-cell CD69 ABC for patients 100 days post-BM transplant were generally below 1 SD of that from healthy volunteers. SEB-stimulated T-cell CD69 expression was significantly depressed for CD8+ T cells while CD4+ T-cell responses to SEB were generally within 1 SD of the mean for healthy volunteers. Discussion These results suggest that quantitative measurement of CD69 surface expression by flow cytometry is a useful diagnostic tool for detailed assessment of T-lymphocyte and subset activation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cytotherapy (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - MITOGENS
KW - FLOW cytometry
KW - BIOLOGICAL assay
KW - SUPERANTIGENS
KW - immune function
KW - immune recovery
KW - immunophenotyping
KW - quantitative flow cytometry.
N1 - Accession Number: 24515651; Lindsey, WB 1 Lowdell, MW 2 Marti, GE 3 Abbasi, F. 3 Zenger, V. 3 King, KM 1 Lamb Jr., LS 1,4; Email Address: Lawrence.Lamb@ccc.uab.edu.; Affiliation: 1: South Carolina Cancer Center. Columbia, South Carolina. USA 2: Royal Free and University College Medical School, University College London. London. UK 3: Center for Biologics Evaluation and Research, Food and Drug Administration. Bethesda, Maryland. USA 4: Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Source Info: Apr2007, Vol. 9 Issue 2, p123; Subject Term: T cells; Subject Term: MITOGENS; Subject Term: FLOW cytometry; Subject Term: BIOLOGICAL assay; Subject Term: SUPERANTIGENS; Author-Supplied Keyword: immune function; Author-Supplied Keyword: immune recovery; Author-Supplied Keyword: immunophenotyping; Author-Supplied Keyword: quantitative flow cytometry.; Number of Pages: 10p; Illustrations: 1 Chart, 26 Graphs; Document Type: Article
L3 - 10.1080/14653240601182838
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Heuijung Lee
AU - Stultz, Brian G.
AU - Hursh, Deborah A.
T1 - The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development.
JO - Development (09501991)
JF - Development (09501991)
Y1 - 2007/04//
VL - 134
IS - 7
M3 - Article
SP - 7
EP - 7
SN - 09501991
AB - The eye/antennal discs of Drosophila form most of the adult head capsule. We are analyzing the role of the BMP family member decapentaplegic (dpp) in the process of head formation, as we have identified a class of cis-regulatory dpp mutations (dppS-hc) that specifically disrupts expression in the lateral peripodial epithelium of eye/antennal discs and is required for ventral head formation. Here we describe the recovery of mutations in odd-paired (opa), a zinc finger transcription factor related to the vertebrate Zic family, as dominant enhancers of this dpp head mutation. A single loss-of-function opa allele in combination with a single copy of a dpp S-hc produces defects in the ventral adult head. Furthermore, postembryonic loss of opa expression alone causes head defects identical to loss of dpp S-hc/dpp S-hc, and dpp S-hc/+;opa/+ mutant combinations. opa is required for dpp expression in the lateral peripodial epithelium, but not other areas of the eye/antennal disc. Thus a pathway that includes opa and dpp expression in the peripodial epithelium is crucial to the formation of the ventral adult head. Zic proteins and members of the BMP pathway are crucial for vertebrate head development, as mutations in them are associated with midline defects of the head. The interaction of these genes in the morphogenesis of the fruitfly head suggests that the regulation of head formation may be conserved across metazoans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Development (09501991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGINAL disks
KW - HEAD
KW - DROSOPHILA
KW - MUTATION (Biology)
KW - ZINC-finger proteins
KW - TRANSCRIPTION factors
KW - Adult head
KW - BMP
KW - decapentaplegic
KW - odd-paired
KW - Peripodial
KW - Zic
N1 - Accession Number: 24489498; Heuijung Lee 1 Stultz, Brian G. 1 Hursh, Deborah A. 1; Email Address: deborah.hurh@fda.hhs.gov; Affiliation: 1: Division of Cell and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2007, Vol. 134 Issue 7, p7; Subject Term: IMAGINAL disks; Subject Term: HEAD; Subject Term: DROSOPHILA; Subject Term: MUTATION (Biology); Subject Term: ZINC-finger proteins; Subject Term: TRANSCRIPTION factors; Author-Supplied Keyword: Adult head; Author-Supplied Keyword: BMP; Author-Supplied Keyword: decapentaplegic; Author-Supplied Keyword: odd-paired; Author-Supplied Keyword: Peripodial; Author-Supplied Keyword: Zic; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowski, Diane K.
T1 - Surveillance of Prescription Drug-Related Mortality Using Death Certificate Data.
JO - Drug Safety
JF - Drug Safety
Y1 - 2007/04//
VL - 30
IS - 6
M3 - Article
SP - 533
EP - 540
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Background: The prescription drugs or drug classes that are most frequently associated with death in the US might be identifiable from death certificate data. Objective: To identify the drugs/drug classes associated with the greatest numbers of deaths in the US that might be considered as possible targets for prevention. Study design: US vital statistics data were accessed in order to identify International Classification of Diseases (10th Revision) [ICD-10] codes indicating that prescription drugs had caused or contributed to death and diseases with significant drug-related mortality. Main outcome measure: ICD-10 codes for primarily prescription drugs that were listed as the underlying cause or as ‘total mentions’ on death certificates and were implicated in =1000 deaths in any one year were selected. The annual number of deaths by ICD-10 code was obtained from the Division of Vital Statistics, National Center for Health Statistics. Codes for diseases with significant drugrelated aetiologies and involvement in =1000 deaths in any one year were also identified and analysed separately. Results: For the selected ICD-10 codes, a total of 25 031 deaths were listed as having a prescription drug as the underlying cause in 2003, compared with 16 135 in 1999, a 55% increase. Total mentions of these codes increased from 46 523 in 1999 to 72 080 in 2003, also a 55% increase. Most codes involved ‘poisonings’ (overdose or the wrong substance given or taken in error that is accidental, intentional or with undetermined intent). Drugs associated with poisoning deaths had central nervous system effects. Among the codes associated with specified drug classes, poisonings and accidental poisonings involving narcotics, hallucinogens, psychoactive substances and opioids (other than opium and heroin) were associated with the largest numbers of deaths. Drug-related codes associated with the largest percentage increases in deaths between 1999 and 2003 included poisoning due to methadone (275%); poisoning by other and unspecified antidepressants (primarily selective serotonin reuptake inhibitors) [130%]; and poisoning by psychostimulants with potential for abuse (amfetamines and drugs for attention deficit hyperactivity disorder) [117%]. Anticoagulants were associated with the largest numbers of deaths with codes involving ‘adverse effects in therapeutic use’. Among diseases with significant drug-related aetiologies, Clostridium difficile enterocolitis (associated primarily with antibacterials) had the largest percentage increase in total mentions, with a 203% rise between 1999 and 2003. Conclusions: Deaths due to overdoses are the most prominent cause of drugrelated mortality in death certificate data. Certain drugs and drug classes, especially the opioids (e.g. narcotics, methadone), psychoactive drugs (e.g. antidepressants, amfetamines), anticoagulants and antibacterials (which cause or contribute to C. difficile enterocolitis) are associated with large and increasing numbers of deaths and preventive strategies should be considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRESCRIPTION of drugs
KW - DRUG monitoring
KW - DEATH -- Causes
KW - DISEASES -- Causes & theories of causation
KW - DEATH certificates
KW - CENTRAL nervous system depressants
KW - PUBLIC health
KW - DEMOGRAPHIC research
KW - MORTALITY
N1 - Accession Number: 25495164; Wysowski, Diane K. 1; Affiliation: 1: Division of Drug Risk Evaluation, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: 2007, Vol. 30 Issue 6, p533; Subject Term: PRESCRIPTION of drugs; Subject Term: DRUG monitoring; Subject Term: DEATH -- Causes; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: DEATH certificates; Subject Term: CENTRAL nervous system depressants; Subject Term: PUBLIC health; Subject Term: DEMOGRAPHIC research; Subject Term: MORTALITY; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jianyong Wang
AU - Tao Chen
AU - Masamitsu Honma
AU - Ling Chen
AU - Martha M. Moore
T1 - 3′‐azido‐3′‐deoxythymidine induces deletions in L5178Y mouse lymphoma cellsThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRT1 therapy.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/04//
VL - 48
IS - 3/4
M3 - Article
SP - 248
EP - 257
SN - 08936692
AB - 3′‐Azido‐3′‐deoxythymidine (AZT), a nucleoside analogue used for the treatment of acquired immunodeficiency syndrome (AIDS), induced a significant dose‐related increase in the thymidine kinase (Tk) mutant frequency (MF) in L5178Y/Tk+/− 3.7.2C mouse lymphoma cells. Treatment with 1 mg/ml (3,742 μM) AZT for 24 hr resulted in a MF of 407 × 10−6 compared to a control MF of 84 × 10−6. The MFs of the large and small colony mutants resulting from AZT exposure were 142 × 10−6 and 265 × 10−6, respectively. One hundred and fifty mutants from the 1 mg/ml (3,742 μM) AZT‐treated culture and sixty‐nine mutants from independent untreated cultures were isolated and analyzed. LOH analysis using a heteromorphic microsatellite locus located in the Tk gene was performed to determine the presence or absence of the Tk+ allele. Eight other microsatellite markers spanning the entire mouse chromosome 11 also were examined for heterozygosity to determine the extent of LOH. In addition, Tk gene dosage analysis was conducted using Real‐Time PCR in those mutants showing LOH at the Tk locus. The presence of only one Tk allele based on Real‐Time PCR indicated that the mutant resulted from deletion while the presence of two alleles was consistent with a recombination event. More mutants from the AZT‐treated culture showed Tk LOH than did independent mutants from the untreated cultures (91% vs. 64%) and the induced mutants also showed distinct chromosome 11 LOH patterns. The mutation spectrum of mutants from AZT‐treated cells was also significantly different from that of spontaneous mutants. More deletions and fewer intragenic mutations were observed in the mutants from the AZT‐treated culture than independent mutants from the untreated control. Our data indicate that AZT primarily induced LOH mutations in L5178Y mouse lymphoma cells and a large number of LOH mutations resulted from deletions. Environ. Mol. Mutagen., 2007. Published 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Molecular Mutagenesis is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIDS (Disease)
KW - Nucleosides
KW - Lymphomas
KW - Thymidine
N1 - Accession Number: 24517163; Jianyong Wang 1,2; Tao Chen 2; Masamitsu Honma 3; Ling Chen 2,4; Martha M. Moore 2; Affiliations: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas; 3: Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan; 4: College of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Issue Info: Apr2007, Vol. 48 Issue 3/4, p248; Thesaurus Term: AIDS (Disease); Subject Term: Nucleosides; Subject Term: Lymphomas; Subject Term: Thymidine; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Linda S. Von Tungeln
AU - Lee D. Williams
AU - Daniel R. Doerge
AU - Joseph G. Shaddock
AU - Lynda J. McGarrity
AU - Suzanne M. Morris
AU - Roberta A. Mittelstaedt
AU - Robert H. Heflich
AU - Frederick A. Beland
T1 - Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudineInvited article on the genotoxicity of perinatal NRTI therapy.The views expressed in this article do not necessarily reflect those of the Food and Drug Administration.This article is a US Government work and, as such, is in the public domain in the United States of America.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/04//
VL - 48
IS - 3/4
M3 - Article
SP - 258
EP - 269
SN - 08936692
AB - In previous studies, we have shown that zidovudine (3′‐azido‐3′‐deoxythymidine; AZT), but not lamivudine [(‐)2′,3′‐dideoxy‐3′‐thiacytidine; 3TC], is genotoxic when administered to neonatal mice, and that 3TC when coadministered with AZT does not alter the responses observed with AZT alone (Von Tungeln et al. [2002] Carcinogenesis 23:1427–1432). We now have investigated the transplacental transfer of these drugs and the induction of mutants and micronuclei in the neonatal offspring. From gestational day 12 until parturition, female C57BL/6N and C57BL/6N/Tk+/− mice, which had been mated to male C3H/HeNMTV mice, were treated daily by gavage with AZT, 3TC, or a combination of AZT and 3TC. In both dams and fetuses, AZT was found at much higher levels than its metabolites, AZT 5′‐glucuronide and 3′‐azido‐3′‐deoxythymidine. In the neonates, AZT and the mixture of AZT and 3TC caused a decrease in the percentage of reticulocytes (RETs) and an increase in the percentage of micronucleated RETs and micronucleated normochromatic erythrocytes. When assessed 3 weeks after birth, AZT and the combination of AZT and 3TC increased the thymidine kinase (Tk) mutant frequency in male mice; at 5 weeks, 3TC increased the Tk mutant frequency in female mice. The increase in Tk mutants in mice treated with AZT and the mixture of AZT and 3TC was associated with loss of the wild‐type (Tk+) allele (loss of heterozygosity; LOH) and a pattern of discontinuous LOH. These data indicate that AZT, 3TC, and the combination of AZT and 3TC are transplacental mutagens and that the increase in mutants resulting from AZT is due mainly to large‐scale genetic alterations. Environ. Mol. Mutagen. 47:, 2006. Published 2006 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Molecular Mutagenesis is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Genetic toxicology
KW - Lymphocytes
KW - AZT (Drug)
N1 - Accession Number: 24517161; Linda S. Von Tungeln 1; Lee D. Williams 1; Daniel R. Doerge 1; Joseph G. Shaddock 2; Lynda J. McGarrity 2; Suzanne M. Morris 2; Roberta A. Mittelstaedt 2; Robert H. Heflich 2; Frederick A. Beland 1; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; Issue Info: Apr2007, Vol. 48 Issue 3/4, p258; Thesaurus Term: Carcinogenesis; Thesaurus Term: Genetic toxicology; Subject Term: Lymphocytes; Subject Term: AZT (Drug); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vasily N. Dobrovolsky
AU - Joseph G. Shaddock
AU - Roberta A. Mittelstaedt
AU - Michelle E. Bishop
AU - Sherry M. Lewis
AU - Fei W. Lee
AU - Anane Aidoo
AU - Julian E.A. Leakey
AU - June K. Dunnick
AU - Robert H. Heflich
T1 - Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TCThis article is a US Government work and, as such, is in the public domain in the United States of America.Invited article on the genotoxicity of perinatal NRTI therapy.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/04//
VL - 48
IS - 3/4
M3 - Article
SP - 270
EP - 282
SN - 08936692
AB - Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother‐to‐child transmission of human immunodeficiency virus I. Combinations of AZT and 3′‐thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC can increase the genotoxicity of AZT. Since p53 plays a key role in human and mouse tumorigenesis, p53‐haplodeficient mice are currently being evaluated as a model for assessing the carcinogenicity of perinatal exposure to NRTIs. In the present study, male C57BL/6 p53+/+ and p53−/− mice were mated with C3H p53+/+ females; the pregnant females were treated on gestation day 12 through parturition with 40, 80, and 160 mg/kg of AZT or a combination of 160 mg/kg AZT and 100 mg/kg 3TC (AZT‐3TC); the p53+/+ and p53+/− offspring were treated daily after birth through postnatal day (PND) 28. The frequencies of micronucleated reticulocytes (MN‐RETs) and micronucleated normochromatic erythrocytes (MN‐NCEs) were determined on PND1, PND10, and PND28; the frequency of Hprt mutant lymphocytes was measured on PND28. The frequencies of MN‐RETs and MN‐NCEs were increased in treated animals at all time points; there were no differences in the responses of p53+/+ and p53+/− animals treated with identical doses of NRTIs. After correction for clonal expansion, both AZT and AZT‐3TC treatments induced small but significant increases in the frequency of Hprt mutant lymphocytes in p53+/− mice, but not in p53+/+ mice. The data indicate that p53 haplodeficiency affects the genotoxicity of NRTIs; thus, p53+/− mice may be a sensitive model for evaluating the carcinogenicity of perinatal exposure to NRTIs. Environ. Mol. Mutagen., 2007. Published 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Molecular Mutagenesis is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lymphocytes
KW - Erythrocytes
KW - AZT (Drug)
KW - Nucleosides
N1 - Accession Number: 24517167; Vasily N. Dobrovolsky 1; Joseph G. Shaddock 1; Roberta A. Mittelstaedt 1; Michelle E. Bishop 1; Sherry M. Lewis 2; Fei W. Lee 2; Anane Aidoo 1; Julian E.A. Leakey 2; June K. Dunnick 3; Robert H. Heflich 1; Affiliations: 1: US Food and Drug Administration, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; 2: Office of Scientific Coordination, National Center for Toxicological Research, Jefferson, Arkansas; 3: National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina; Issue Info: Apr2007, Vol. 48 Issue 3/4, p270; Subject Term: Lymphocytes; Subject Term: Erythrocytes; Subject Term: AZT (Drug); Subject Term: Nucleosides; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sullivan, Patricia A.
T1 - Vermiculite, Respiratory Disease, and Asbestos Exposure in Libby, Montana: Update of a Cohort Mortality Study.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/04//
VL - 115
IS - 4
M3 - Article
SP - 579
EP - 585
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Vermiculite from the mine near Libby, Montana, is contaminated with tremolite asbestos and other amphibole fibers (winchite and richterite). Asbestos-contaminated Libby vermiculite was used in loose-fill attic insulation that remains in millions of homes in the United States, Canada, and other countries. OBJECTIVE: This report describes asbestos-related occupational respiratory disease mortality among workers who mined, milled, and processed the Libby vermiculite. METHODS: This historical cohort mortality study uses life table analysis methods to compare the age-adjusted mortality experience through 2001 of 1,672 Libby workers to that of white men in the U.S. population. RESULTS: Libby workers were significantly more likely to die from asbestosis [standardized mortality ratio (SMR) = 165.8; 95% confidence interval (CI), 103.9-251.1], lung cancer (SMR = 1.7; 95% CI, 1.4-2.1), cancer of the pleura (SMR = 23.3; 95% CI, 6.3-59.5), and mesothelioma. Mortality from asbestosis and lung cancer increased with increasing duration and cumulative exposure to airborne tremolite asbestos and other amphibole fibers. CONCLUSIONS: The observed dose-related increases in asbestosis and lung cancer mortality highlight the need for better understanding and control of exposures that may occur when homeowners or construction workers (including plumbers, cable installers, electricians, telephone repair personnel, and insulators) disturb loose-fill attic insulation made with asbestos-contaminated vermiculite from Libby, Montana. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vermiculite
KW - Asbestosis
KW - Lungs -- Cancer
KW - Men -- Mortality
KW - Tremolite
KW - Fibers
KW - Respiratory diseases
KW - Mesothelioma -- Risk factors
KW - Libby (Mont.)
KW - Montana
KW - United States
KW - amphibole fibers
KW - asbestos
KW - asbestos-related disease
KW - asbestosis
KW - insulation
KW - lung cancer
KW - mesothelioma
KW - richterite
KW - tremolite
KW - winchite
N1 - Accession Number: 24779069; Sullivan, Patricia A. 1; Email Address: PSullivan@cdc.gov; Affiliations: 1: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Apr2007, Vol. 115 Issue 4, p579; Thesaurus Term: Vermiculite; Thesaurus Term: Asbestosis; Subject Term: Lungs -- Cancer; Subject Term: Men -- Mortality; Subject Term: Tremolite; Subject Term: Fibers; Subject Term: Respiratory diseases; Subject Term: Mesothelioma -- Risk factors; Subject: Libby (Mont.); Subject: Montana; Subject: United States; Author-Supplied Keyword: amphibole fibers; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: asbestos-related disease; Author-Supplied Keyword: asbestosis; Author-Supplied Keyword: insulation; Author-Supplied Keyword: lung cancer; Author-Supplied Keyword: mesothelioma; Author-Supplied Keyword: richterite; Author-Supplied Keyword: tremolite; Author-Supplied Keyword: winchite; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shields, Anthony F.
AU - Briston, David A.
AU - Chandupatla, Samatha
AU - Douglas, Kirk A.
AU - Lawhorn-Crews, Jawana
AU - Collins, Jerry M.
AU - Mangner, Thomas J.
AU - Heilbrun, Lance K.
AU - Muzik, Otto
T1 - A simplified analysis of [18F]3′-deoxy-3′-fluorothymidine metabolism and retention.
JO - European Journal of Nuclear Medicine & Molecular Imaging
JF - European Journal of Nuclear Medicine & Molecular Imaging
Y1 - 2007/04//
VL - 34
IS - 4
M3 - Correction notice
SP - 613
EP - 613
PB - Springer Science & Business Media B.V.
SN - 16197070
AB - A correction to the article "A Simplified Analysis of [18F]3'-deoxy-3'-Fluorothymidine Metabolism and Retention" that was published in the January 9, 2007 issue is presented.
KW - METABOLITES
N1 - Accession Number: 24362953; Shields, Anthony F. 1,2; Email Address: shieldsa@karmanos.org Briston, David A. 1,2 Chandupatla, Samatha 2 Douglas, Kirk A. 1,2 Lawhorn-Crews, Jawana 1 Collins, Jerry M. 3 Mangner, Thomas J. 1,4 Heilbrun, Lance K. 1 Muzik, Otto 5; Affiliation: 1: Karmanos Cancer Institute, 4100 John R Street, 4 HWCRC, Detroit, MI 48201-2013, USA. 2: Department of Internal Medicine, Wayne State University, Detroit, MI, USA. 3: Food and Drug Administration, Rockville, MD, USA. 4: Department of Radiology, Wayne State University, Detroit, MI, USA. 5: Department of Pediatrics, Wayne State University, Detroit, MI, USA.; Source Info: Apr2007, Vol. 34 Issue 4, p613; Subject Term: METABOLITES; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1007/s00259-006-0335-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salazar, Edith L.
AU - Calzada, Leobardo
T1 - The role of progesterone in endometrial estradiol- and progesterone-receptor synthesis in women with menstrual disorders and habitual abortion.
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
Y1 - 2007/04//
VL - 23
IS - 4
M3 - Article
SP - 222
EP - 225
PB - Taylor & Francis Ltd
SN - 09513590
AB - The objective of this comparative study was to determine the influence of changes in estradiol and progesterone during ovulatory vs. anovulatory cycles on levels of estradiol receptor (ER) and progesterone receptor (PgR) in endometrium. Thirty women (range age 20-35 years) were divided into three groups: women with a history of habitual abortion, obese women with menstrual disorders, and women with regular ovulatory cycles as well as proven fertility. A single venous blood sample and an endometrial sample were simultaneously obtained during the secretory phase of the menstrual cycle, in order to measure estradiol and progesterone levels and ER and PgR concentrations in cytosol and salt-extracted nucleosol. Plasma estradiol levels were not different between groups. Plasma progesterone was two times higher in fertile women than in habitual aborters. In endometrial tissue, progesterone content was 200 times higher in fertile women than in habitual aborters. ER and PgR were lower in the cytosol than in the nuclear fraction in fertile and obese women. Both receptors were at their lowest level in the cytosol and nuclear compartment of women with recurrent miscarriage. Fluctuations mainly in the sex hormone progesterone, in plasma and endometrium tissue, could interfere with ER and PgR levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTRADIOL
KW - PROGESTERONE
KW - MENSTRUATION disorders
KW - ENDOMETRIUM
KW - ABORTION
KW - HORMONE receptors
KW - Endometrium
KW - habitual abortion
KW - hormone receptors
KW - menstrual disorders
N1 - Accession Number: 25084824; Salazar, Edith L. 1; Email Address: dra_edith_salazar@yahoo.com.mx Calzada, Leobardo 2; Affiliation: 1: Medical Research Unit in Endocrine Disease, Medical Research Coordination, Social Security Mexican Institute (IMSS), Mexico City, Mexico 2: Health Center (T-III) Dr Manuel Escontria, Sanitary Jurisdiction Alvaro Obregon, Public Health Service of Distrito Federal, Mexico City, Mexico; Source Info: Apr2007, Vol. 23 Issue 4, p222; Subject Term: ESTRADIOL; Subject Term: PROGESTERONE; Subject Term: MENSTRUATION disorders; Subject Term: ENDOMETRIUM; Subject Term: ABORTION; Subject Term: HORMONE receptors; Author-Supplied Keyword: Endometrium; Author-Supplied Keyword: habitual abortion; Author-Supplied Keyword: hormone receptors; Author-Supplied Keyword: menstrual disorders; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/09513590701254030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Rickie R.
AU - Kuo, Ming-Wen
AU - Stanton, Susan G.
AU - Canlon, Barbara
AU - Krieg, Edward
AU - Alagramam, Kumar N.
T1 - N-Acetyl l-cysteine does not protect against premature age-related hearing loss in C57BL/6J mice: A pilot study
JO - Hearing Research
JF - Hearing Research
Y1 - 2007/04//
VL - 226
IS - 1/2
M3 - Article
SP - 203
EP - 208
SN - 03785955
AB - Abstract: A compound capable of preventing age-related hearing loss would be very useful in an aging population. N-acetyl-l-cysteine (l-NAC) has been shown to be protective against noise exposure, a condition that leads to increased oxidative stress. Not withstanding environmental factors, there is evidence that age-related hearing loss (AHL) in the mouse is linked to more than one genetic loci and, by extension, in humans. Our hypothesis is that AHL defect results in increased sensitivity to oxidative stress and l-NAC would be able to protect the hearing of a mouse model of pre-mature AHL, the C57BL/6J (B6) mouse strain. l-NAC was added to the regular water bottle of B6 mice (experimental group) and available ad lib. The other group received normal tap water. Hearing was tested monthly by the ability to generate the auditory brainstem response (ABR). After the final ABR test, mice were sacrificed by an overdose of Avertin, ears were harvested and hair cell loss was quantified. There was no difference in ABR thresholds or in histopathology between the control group and the group receiving l-NAC in their drinking water. In contrast to the protective effects of l-NAC against noise-induced hearing loss, the lack of protective effect in this study may be due to (i) the dosage level; (ii) the duration of treatment; (iii) the biochemical mechanisms underlying age-induced hearing loss; or (iv) how the mouse metabolizes l-NAC. [Copyright &y& Elsevier]
AB - Copyright of Hearing Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER deaf people
KW - ACTIVE oxygen
KW - OXIDATIVE stress
KW - OXIDATION-reduction reaction
KW - Age-related
KW - Auditory brainstem response
KW - Cochleogram
KW - Hearing loss
KW - Mouse
KW - Presbycusis
KW - Reactive oxygen species
N1 - Accession Number: 24460567; Davis, Rickie R. 1,2; Email Address: rrd1@cdc.gov Kuo, Ming-Wen 3 Stanton, Susan G. 3 Canlon, Barbara 4 Krieg, Edward 5 Alagramam, Kumar N. 6; Affiliation: 1: Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, C-27, 4676 Columbia Parkway, Cincinnati, OH 45226, United States 2: Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, United States 3: Department of Communication Sciences and Disorders, College of Allied Health Sciences, University of Cincinnati Medical Center, Cincinnati, OH, United States 4: Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden 5: Communication and Statistics Team, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, United States 6: Department of Otolaryngology-HNS, Case Western Reserve University, Cleveland, OH, 44106, United States; Source Info: Apr2007, Vol. 226 Issue 1/2, p203; Subject Term: OLDER deaf people; Subject Term: ACTIVE oxygen; Subject Term: OXIDATIVE stress; Subject Term: OXIDATION-reduction reaction; Author-Supplied Keyword: Age-related; Author-Supplied Keyword: Auditory brainstem response; Author-Supplied Keyword: Cochleogram; Author-Supplied Keyword: Hearing loss; Author-Supplied Keyword: Mouse; Author-Supplied Keyword: Presbycusis; Author-Supplied Keyword: Reactive oxygen species; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.heares.2006.07.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105928918
T1 - Book review. Tissue economics: blood, organs, and cell lines in late capitalism.
AU - Chasin S
Y1 - 2007///Spring2007
N1 - Accession Number: 105928918. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 0411772.
KW - Biotechnology
KW - Organ Procurement
SP - 37
EP - 38
JO - Hospital Topics
JF - Hospital Topics
JA - HOSP TOP
VL - 85
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 0018-5868
AD - Deputy Director, Office of Surveillance and Biomentrics, Food and Drug Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Otsuka, Yasumasa
AU - Takahashi, Masaya
AU - Nakata, Akinori
AU - Haratani, Takashi
AU - Kaida, Kosuke
AU - Fukasawa, Kenji
AU - Hanada, Takanobu
AU - Ito, Akiko
T1 - Sickness Absence in Relation to Psychosocial Work Factors among Daytime Workers in an Electric Equipment Manufacturing Company.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/04//
VL - 45
IS - 2
M3 - Article
SP - 224
EP - 231
SN - 00198366
AB - The article focuses on the cross-sectional study about the association between sickness absence and psychosocial work factors among 883 daytime workers in an electric equipment manufacturing company. The study suggests that appropriate use of sickness absence at times of being exposed to high quantitative workload may help male workers recover from stressful situations.
KW - Sick leave
KW - Psychosocial factors
KW - Occupational sociology
KW - Industrial sociology
KW - Employee fringe benefits
KW - Manufacturing industries
KW - Job stress
KW - Occupation
KW - Presenteeism
KW - Psychosocial work factors
KW - Sex
KW - Sickness absence
N1 - Accession Number: 25812149; Otsuka, Yasumasa 1; Takahashi, Masaya 1; Nakata, Akinori 1; Haratani, Takashi 1; Kaida, Kosuke 1,2; Fukasawa, Kenji 1; Hanada, Takanobu 3; Ito, Akiko 3; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa 214-8585, Japan; 2: Japan Society for the Promotion of Science, 6 Ichiban-cho, Chiyoda-ku, Tokyo 102-8471, Japan; 3: Kanazawa Aozora Clinic, 7-6-175 Okawa, Kanazawa-ku, Yokohama, Kanagawa 236-0043, Japan; Issue Info: 2007, Vol. 45 Issue 2, p224; Subject Term: Sick leave; Subject Term: Psychosocial factors; Subject Term: Occupational sociology; Subject Term: Industrial sociology; Subject Term: Employee fringe benefits; Subject Term: Manufacturing industries; Subject Term: Job stress; Author-Supplied Keyword: Occupation; Author-Supplied Keyword: Presenteeism; Author-Supplied Keyword: Psychosocial work factors; Author-Supplied Keyword: Sex; Author-Supplied Keyword: Sickness absence; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sasaki, Takeshi
AU - Iwasaki, Kenji
AU - Mori, Ippei
AU - Hisanaga, Naomi
AU - Shibata, Eiji
T1 - Overtime, Job Stressors, Sleep/Rest, and Fatigue of Japanese Workers in a Company.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/04//
VL - 45
IS - 2
M3 - Article
SP - 237
EP - 246
SN - 00198366
AB - The article focuses on the study that examines the associations between overtime work, job stressors, or the quantity of sleep/rest and subjective symptoms of fatigue of Japanese workers at a plant of a manufacturing company, and whether sleeping hours and monthly days off are associated with the accumulated fatigue parameter. Objective of the study was to determine the usefulness of a 21-item checklist. The study suggests that it may be possible to assess overwork by the fatigue guideline.
KW - Job stress
KW - Overtime
KW - Mental fatigue
KW - Fatigue
KW - Industrial workers
KW - Japan
KW - Job stressors
KW - Overtime work
KW - Overwork
KW - Rest
KW - Sleep
N1 - Accession Number: 25812151; Sasaki, Takeshi 1; Iwasaki, Kenji 1; Mori, Ippei 1; Hisanaga, Naomi 2; Shibata, Eiji 3; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Center for Campus Health and Environment, Aichi University of Education, Hirosawa 1, Igaya-cho, Kariya, Aichi 448-8542, Japan; 3: Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan; Issue Info: 2007, Vol. 45 Issue 2, p237; Subject Term: Job stress; Subject Term: Overtime; Subject Term: Mental fatigue; Subject Term: Fatigue; Subject Term: Industrial workers; Subject: Japan; Author-Supplied Keyword: Job stressors; Author-Supplied Keyword: Overtime work; Author-Supplied Keyword: Overwork; Author-Supplied Keyword: Rest; Author-Supplied Keyword: Sleep; Number of Pages: 10p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kaida, Kosuke
AU - Takahashi, Masaya
AU - Otsuka, Yasumasa
T1 - A Short Nap and Natural Bright Light Exposure Improve Positive Mood Status.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/04//
VL - 45
IS - 2
M3 - Article
SP - 301
EP - 308
SN - 00198366
AB - The article focuses on the study that examines the effects of a short nap and natural bright light exposure on mood status. In measuring mood status, multiple visual analogue scales and the Mood Check List 3 (MCL-3) were employed. The results showed that brief natural bright light 30 minutes exposure improved one dimension of mood status. The study suggests that the proper application of both natural light and a short nap shifts the mood status to the positive/favorable side.
KW - Mood (Psychology)
KW - Affective disorders
KW - Naps (Sleep)
KW - Light -- Physiological effect
KW - Sleep
KW - Drowsiness
KW - Mood status
KW - Short daytime nap
KW - Sleepiness
KW - words: Natural bright light
N1 - Accession Number: 25812158; Kaida, Kosuke 1; Takahashi, Masaya 1; Otsuka, Yasumasa 1; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki, Kanagawa 214-8585, Japan; Issue Info: 2007, Vol. 45 Issue 2, p301; Subject Term: Mood (Psychology); Subject Term: Affective disorders; Subject Term: Naps (Sleep); Subject Term: Light -- Physiological effect; Subject Term: Sleep; Subject Term: Drowsiness; Author-Supplied Keyword: Mood status; Author-Supplied Keyword: Short daytime nap; Author-Supplied Keyword: Sleepiness; Author-Supplied Keyword: words: Natural bright light; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jones, Ellen L.
AU - Kramer, Adam
AU - Gaither, Marlene
AU - Gerba, Charles P.
T1 - Role of fomite contamination during an outbreak of norovirus on houseboats.
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 123
EP - 131
PB - Taylor & Francis Ltd
SN - 09603123
AB - An outbreak of suspected norovirus gastroenteritis among three consecutive groups of houseboaters on a large recreational lake in Arizona was investigated to assess the role of fomite contamination, and to provide recommendations for prevention of future outbreaks. Interior boat surfaces were sampled for norovirus using transport swabs. Onboard toilet reservoirs were swabbed as a surrogate for stool samples from ill participants, since none were available, and onboard potable water supplies were sampled for norovirus. All samples were analyzed using RT-PCR with primers specific for human norovirus. Widespread fomite contamination was documented in the houseboats; 83% (5/6) of bathroom surface samples, 40% (2/5) of kitchen surface samples, and 100% (3/3) of doorknob samples were positive for the presence of norovirus. Samples of onboard potable water supplies were all negative. One of the participants on the first boating trip arrived already displaying symptoms of gastrointestinal illness prior to boarding the boat. This investigation demonstrates the potential role of widespread fomite contamination in outbreaks in confined spaces. To prevent or minimize future outbreaks in confined spaces, the adoption of practices such as surface disinfection and the utilization of methods to identify and exclude those with gastroenteritis from trips or activities in confined spaces, where others may become infected, are recommended. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Environmental Health Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Disinfection & disinfectants
KW - Communicable diseases
KW - Virus diseases -- Transmission
KW - Gastrointestinal diseases -- Prevention
KW - Houseboats
KW - Gastroenteritis -- Prevention
KW - Virus-vector relationships
KW - Door knobs -- Evaluation
KW - Bathrooms -- Safety measures
KW - fomite
KW - lake
KW - Norovirus
KW - outbreak
KW - recreation
KW - water
N1 - Accession Number: 25727831; Jones, Ellen L. 1; Kramer, Adam 2; Gaither, Marlene 3; Gerba, Charles P. 1; Affiliations: 1: Department of Soil, Water, and Environmental Science, University of Arizona. Tucson, Arizona. USA; 2: Public Health Service/National Park Service, Intermountain Region. Flagstaff, Arizona. USA; 3: Coconino County Health Department, Environmental Health Division. Flagstaff, Arizona. USA; Issue Info: Apr2007, Vol. 17 Issue 2, p123; Thesaurus Term: Disinfection & disinfectants; Thesaurus Term: Communicable diseases; Subject Term: Virus diseases -- Transmission; Subject Term: Gastrointestinal diseases -- Prevention; Subject Term: Houseboats; Subject Term: Gastroenteritis -- Prevention; Subject Term: Virus-vector relationships; Subject Term: Door knobs -- Evaluation; Subject Term: Bathrooms -- Safety measures; Author-Supplied Keyword: fomite; Author-Supplied Keyword: lake; Author-Supplied Keyword: Norovirus; Author-Supplied Keyword: outbreak; Author-Supplied Keyword: recreation; Author-Supplied Keyword: water; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/09603120701219394
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yi Tsong
T1 - The Utility of Active-Controlled Noninferiority/Equivalence Trials in Drug Development.
JO - International Journal of Pharmaceutical Medicine
JF - International Journal of Pharmaceutical Medicine
Y1 - 2007/04//
VL - 21
IS - 3
M3 - Article
SP - 225
EP - 233
SN - 13649027
AB - Clinical trials designed with the objective of demonstrating that a test treatment is noninferior or equivalent to an active control treatment have long been used in drug development. In general, in order to fulfil the requirement of a New Drug Application, a sponsor needs to conduct randomised clinical trials to demonstrate that the test treatment is effective. With placebo control in the clinical trial, efficacy of the test treatment is demonstrated by showing that the test treatment is statistically and clinically superior to placebo. However, because of the ethical concerns of exposing patients to placebo when there is a proven therapeutic method available, many clinical trials can only be designed with the approved active control treatment. Because of the lack of placebo exposure in the current clinical trial, neither the sponsor nor the regulatory reviewer can assess whether the test treatment is superior to placebo directly. When the concept of noninferiority and equivalence of bioequivalence trials is applied to this type of trial, it complicates the efficacy assessment of the test treatment (superior to placebo) because of the indirectness of the comparison. This article discusses the fundamental concepts of noninferiority and equivalence testing applied in some specific drug products and how they are extended in the application for the interpretation for 'test treatment is superior to placebo' assessment. It also discusses why such an application makes the drug evaluation so complicated. The limitations and recommendations for the use of noninferiority or equivalence testing will also be considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Pharmaceutical Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL drug trials
KW - CLINICAL trials
KW - DRUG development
KW - PLACEBOS (Medicine)
KW - CLINICAL pharmacology
N1 - Accession Number: 25529115; Yi Tsong 1; Email Address: yi.tsong@fda.hhs.gov; Affiliation: 1: Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: 2007, Vol. 21 Issue 3, p225; Subject Term: CLINICAL drug trials; Subject Term: CLINICAL trials; Subject Term: DRUG development; Subject Term: PLACEBOS (Medicine); Subject Term: CLINICAL pharmacology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Owusu-Edusei, Kwame, Jr.
AU - Espey, Molly
AU - Lin, Huiyan
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health
AD - Clemson U
AD - Capital One
T1 - Does Close Count? School Proximity, School Quality, and Residential Property Values
JO - Journal of Agricultural and Applied Economics
JF - Journal of Agricultural and Applied Economics
Y1 - 2007/04//
VL - 39
IS - 1
SP - 211
EP - 221
SN - 10740708
N1 - Accession Number: 0933418; Keywords: Residential; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200710
N2 - This study jointly estimates the impact of school quality and school proximity on residential property values in Greenville, South Carolina. While quality is found to be capitalized into residential property values, the degree of capitalization depends on school level and proximity to each school for which the house is zoned for attendance. In general, there is positive value associated with closer proximity to schools of all levels, and negative value associated with a significantly longer than average distance to schools. In terms of quality rankings, excellence at the elementary and high school levels has the strongest impact on property values.
KW - Analysis of Education I21
KW - Housing Supply and Markets R31
L3 - http://www.saea.org/currentback-issues-indexes/
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UR - http://www.saea.org/currentback-issues-indexes/
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Owusu-Edusei Jr., K.
AU - Biddle, E. A.
T1 - Installing a Cost-Effective Rollover Protective Structure (CROPS): A Cost-Effectiveness Analysis.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2007/04//
VL - 13
IS - 2
M3 - Article
SP - 165
EP - 176
SN - 10747583
AB - This article presents an analysis of the cost effectiveness of installing a cost-effective rollover protective structure. Cost-effective rollover protective structures are tractor model-specific rollover protective structures and are as effective as existing rollover protective structures retrofits, but costs less. The study estimated the expected effects and costs at a per-tractor level for two options: Install-Cost-effective rollover protective structures and No-rollover protective structures.
KW - Cost effectiveness
KW - Engines
KW - Cost analysis
KW - Research
KW - Rollover protective structures (Machinery)
KW - Machinery -- Safety appliances
KW - Agricultural equipment -- Rollover protective structures
KW - Tractors
KW - Cost control
KW - Cost-effectiveness analysis
KW - CROPS
KW - Decision tree
KW - Dominance
KW - Net savings
KW - ROPS
KW - Sensitivity analysis
N1 - Accession Number: 25120639; Owusu-Edusei Jr., K. 1; Email Address: kfo0@cdc.gov; Biddle, E. A. 2; Affiliations: 1: Prevention Effectiveness Fellow, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Economist, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Apr2007, Vol. 13 Issue 2, p165; Thesaurus Term: Cost effectiveness; Thesaurus Term: Engines; Thesaurus Term: Cost analysis; Thesaurus Term: Research; Subject Term: Rollover protective structures (Machinery); Subject Term: Machinery -- Safety appliances; Subject Term: Agricultural equipment -- Rollover protective structures; Subject Term: Tractors; Subject Term: Cost control; Author-Supplied Keyword: Cost-effectiveness analysis; Author-Supplied Keyword: CROPS; Author-Supplied Keyword: Decision tree; Author-Supplied Keyword: Dominance; Author-Supplied Keyword: Net savings; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: Sensitivity analysis; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; Number of Pages: 12p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Owusu-Edusei Jr., K.
AU - Biddle, E. A.
T1 - A Stable Dynamic Cohort Analysis of Installing Cost-Effective Rollover Protective Structures (CROPS).
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2007/04//
VL - 13
IS - 2
M3 - Article
SP - 177
EP - 187
SN - 10747583
AB - This article presents an analysis of installing cost-effective rollover protective structures. A dynamic group of the estimated retrofittable non-rollover protective structure tractors was tracked over a 20-year period to determine the expected costs and the expected number of fatal and non-fatal injuries resulting from tractor overturns. For a starting size of 1,065,164, the Install-cost-effective rollover protective structures option prevented an estimated total of 878 injuries over the 20-year period.
KW - Cost effectiveness
KW - Engines
KW - Wounds & injuries
KW - Rollover protective structures (Machinery)
KW - Machinery -- Safety appliances
KW - Agricultural equipment -- Rollover protective structures
KW - Tractors
KW - Traction-engines
KW - Cohort analysis
KW - Cost-effectiveness analysis
KW - CROPS
KW - ROPS
KW - Sensitivity analysis
KW - Stable dynamic cohort
N1 - Accession Number: 25120640; Owusu-Edusei Jr., K. 1; Email Address: kfo0@cdc.gov; Biddle, E. A. 2; Affiliations: 1: Prevention Effectiveness Fellow, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Economist, Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Apr2007, Vol. 13 Issue 2, p177; Thesaurus Term: Cost effectiveness; Thesaurus Term: Engines; Thesaurus Term: Wounds & injuries; Subject Term: Rollover protective structures (Machinery); Subject Term: Machinery -- Safety appliances; Subject Term: Agricultural equipment -- Rollover protective structures; Subject Term: Tractors; Subject Term: Traction-engines; Subject Term: Cohort analysis; Author-Supplied Keyword: Cost-effectiveness analysis; Author-Supplied Keyword: CROPS; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: Sensitivity analysis; Author-Supplied Keyword: Stable dynamic cohort; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; Number of Pages: 11p; Illustrations: 1 Diagram, 5 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hines, C. J.
AU - Deddens, J. A.
AU - Coble, J.
AU - Alavanja, M. C. R.
T1 - Fungicide Application Practices and Personal Protective Equipment Use among Orchard Farmers in the Agricultural Health Study.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2007/04//
VL - 13
IS - 2
M3 - Article
SP - 205
EP - 223
SN - 10747583
AB - This article discusses on the personal protective equipment use and fungicide application practices among orchard farmers in the agricultural health study. Seventy-four private orchard applicators participated in the Orchard Fungicide Exposure Study in 2002-2003. During 144 days of observation, information was obtained on chemicals applied and applicator mixing, personal protective, application, and hygiene practices. Air blast was the most frequent application method used and rubber gloves were the most frequently worn protective equipment.
KW - Protective clothing
KW - Industrial safety
KW - Health
KW - Farms
KW - Agriculture
KW - Agricultural laborers
KW - Orchards
KW - Fungicides
KW - Gloves
KW - Apple
KW - Fungicide
KW - Orchard
KW - Peach
KW - Personal protective equipment
KW - Pesticide
KW - Work practices
N1 - Accession Number: 25120642; Hines, C. J. 1; Email Address: chines@cdc.gov; Deddens, J. A. 2; Coble, J. 3; Alavanja, M. C. R. 4; Affiliations: 1: Research Health Scientist, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Professor of Mathematical Sciences, National Institute for Occupational Safety and Health, Cincinnati, Ohio, and Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio; 3: Staff Scientist, National Cancer Institute, Rockville, Maryland; 4: Captain USPHS, National Cancer Institute, Rockville, Maryland; Issue Info: Apr2007, Vol. 13 Issue 2, p205; Thesaurus Term: Protective clothing; Thesaurus Term: Industrial safety; Thesaurus Term: Health; Thesaurus Term: Farms; Thesaurus Term: Agriculture; Thesaurus Term: Agricultural laborers; Thesaurus Term: Orchards; Thesaurus Term: Fungicides; Subject Term: Gloves; Author-Supplied Keyword: Apple; Author-Supplied Keyword: Fungicide; Author-Supplied Keyword: Orchard; Author-Supplied Keyword: Peach; Author-Supplied Keyword: Personal protective equipment; Author-Supplied Keyword: Pesticide; Author-Supplied Keyword: Work practices; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; Number of Pages: 19p; Illustrations: 9 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yi Tsong
T1 - Special Issue on Active Controlled Clinical Trials - Guest Editor's Note.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 197
EP - 199
PB - Taylor & Francis Ltd
SN - 10543406
AB - The article discusses various reports published within the issue, including on by Hung on the noninferiority test using the controlling type I error rate and another by Tsong and Zhang on the comparative study on type I error rate of superiority test using the test and active control arm in clinical trial.
KW - PREFACES & forewords
KW - BIOMETRY
N1 - Accession Number: 24333860; Yi Tsong 1; Affiliation: 1: Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration. Silver Spring, Maryland. USA; Source Info: Apr2007, Vol. 17 Issue 2, p197; Subject Term: PREFACES & forewords; Subject Term: BIOMETRY; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10543400601177269
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koti, Kallappa M.
T1 - Use of the Fieller-Hinkley Distribution of the Ratio of Random Variables in Testing for Noninferiority.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 215
EP - 228
PB - Taylor & Francis Ltd
SN - 10543406
AB - We address the noninferiority assessment problem defined in terms of the ratio of population means in a parallel group design analysis of variance setting. The sample ratio as a point estimate of the corresponding population ratio has been considered. It has been shown that the Fieller-Hinkley distribution of the ratio of two correlated normally distributed random variables readily provide a technique for constructing confidence intervals comparable to the bootstrap percentile and Fieller's confidence intervals. A finite parameter space based level α test of an inferiority hypothesis formulated in terms of a fixed margin has been derived. We illustrate our approach using the forced vital capacity (FVC) data. We claim that it is easy to construct and straight forward to interpret our bootstrap equivalent confidence intervals that are used to assess noninferiority. We discuss appropriate methods for calculation of sample sizes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMETRY
KW - BIOMATHEMATICS
KW - CLINICAL drug trials
KW - CLINICAL trials
KW - CLINICAL medicine
KW - MEDICAL experimentation on humans
KW - PHARMACOLOGY
KW - BIOPHARMACEUTICS
KW - Bivariate normal integral
KW - Bootstrap percentile interval
KW - Rejection region
N1 - Accession Number: 24333856; Koti, Kallappa M. 1; Email Address: kallappa.koti@fda.hhs.gov; Affiliation: 1: Division of Biometrics, United States Food and Drug Administration. Silver Spring, Maryland. USA; Source Info: Apr2007, Vol. 17 Issue 2, p215; Subject Term: BIOMETRY; Subject Term: BIOMATHEMATICS; Subject Term: CLINICAL drug trials; Subject Term: CLINICAL trials; Subject Term: CLINICAL medicine; Subject Term: MEDICAL experimentation on humans; Subject Term: PHARMACOLOGY; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Bivariate normal integral; Author-Supplied Keyword: Bootstrap percentile interval; Author-Supplied Keyword: Rejection region; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 14p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400601177335
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koti, Kallappa M.
T1 - New Tests for Null Hypothesis of Non Unity Ratio of Proportions.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 229
EP - 245
PB - Taylor & Francis Ltd
SN - 10543406
AB - Testing for noninferiority and equivalence between an experimental therapy and a standard therapy in terms of the ratio of binomial proportions is considered. New tests based on the Fieller-Hinkley distribution of the ratio of random variables are proposed. Restricted maximum likelihood estimates of the null variances are used to derive the tests. Sample size determination is discussed. The proposed test procedure is extended to multiple tables. The tests are applied to numerical examples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICAL hypothesis testing
KW - EXPERIMENTAL medicine
KW - EXPERIMENTAL pharmacology
KW - BIOMETRY
KW - CLINICAL trials
KW - MEDICAL experimentation on humans
KW - PHARMACOLOGY
KW - BIOPHARMACEUTICS
KW - Active control
KW - Binary data
KW - Clinical trials
KW - Risk ratio
KW - Stratified analysis
N1 - Accession Number: 24333855; Koti, Kallappa M. 1; Email Address: kallappa.koti@fda.hhs.gov; Affiliation: 1: United States Food and Drug Administration, New Hampshire Avenue. Silver Spring, Maryland. USA; Source Info: Apr2007, Vol. 17 Issue 2, p229; Subject Term: STATISTICAL hypothesis testing; Subject Term: EXPERIMENTAL medicine; Subject Term: EXPERIMENTAL pharmacology; Subject Term: BIOMETRY; Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: PHARMACOLOGY; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Active control; Author-Supplied Keyword: Binary data; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Risk ratio; Author-Supplied Keyword: Stratified analysis; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 17p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10543400601177426
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tie-Hua Ng
T1 - Simultaneous Testing of Noninferiority and Superiority Increases the False Discovery Rate.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 259
EP - 264
PB - Taylor & Francis Ltd
SN - 10543406
AB - It is well recognized that multiplicity adjustment is not necessary in simultaneous testing for noninferiority and superiority. However, Ng (2003) argued that there will be more experimental treatments that are expected to have the same effect as the active control tested for superiority in simultaneous testing than would occur if only one null hypothesis is tested, thereby increasing erroneous claims of superiority. This leads to an increase in the false discovery rate for superiority. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL drug trials
KW - BAYESIAN analysis
KW - PROBABILITY theory
KW - DRUG bioavailability
KW - PHARMACOLOGY
KW - BIOPHARMACEUTICS
KW - Active control
KW - Bayesian
KW - False discovery rate
KW - Multiplicity adjustment
KW - Noninferiority
KW - Simultaneous testing
N1 - Accession Number: 24333868; Tie-Hua Ng 1; Email Address: tiehua.ng@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Rockville Pike. Rockville, Maryland. USA; Source Info: Apr2007, Vol. 17 Issue 2, p259; Subject Term: CLINICAL drug trials; Subject Term: BAYESIAN analysis; Subject Term: PROBABILITY theory; Subject Term: DRUG bioavailability; Subject Term: PHARMACOLOGY; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Active control; Author-Supplied Keyword: Bayesian; Author-Supplied Keyword: False discovery rate; Author-Supplied Keyword: Multiplicity adjustment; Author-Supplied Keyword: Noninferiority; Author-Supplied Keyword: Simultaneous testing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/10543400601177459
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsou, Hsiao-Hui
AU - Hsiao, Chin-Fu
AU - Chow, Shein-Chung
AU - Yue, Lilly
AU - Xu, Yunling
AU - Lee, Shiowjen
T1 - Mixed Noninferiority Margin and Statistical Tests in Active Controlled Trials.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 339
EP - 357
PB - Taylor & Francis Ltd
SN - 10543406
AB - In an active controlled noninferiority trial without a placebo arm, one of the major considerations is the selection of the noninferiority margin. Although the ICH E10 guideline provides general principles for the selection of appropriate noninferiority margins, there are no established rules or gold standards for the selection of noninferiority margins in active control trials. Hung et al. (2003) proposed a margin selection based on relative risk. However, with relative risk, it is difficult to adjust for covariates. On the other hand, Chow and Shao (2006) proposed a method for selecting noninferiority margins based on treatment difference. The determination of noninferiority margin based on either a test for treatment difference or a test for relative risk would be critical. In this paper, we propose a method for noninferiority testing with the use of a mixed null hypothesis. The mixed null hypothesis consists of a margin based on treatment difference and a margin based on relative risk. Both noninferiority margins will simultaneously satisfy the principles as described in the ICH E10 guideline. Statistical tests for mixed noninferiority margin are also derived. An example concerning the efficacy of a test therapy to an active control on a clinical adverse event in the target patient population with cardiovascular disease is presented to illustrate the proposed method. Simulation studies were also conducted to assess the type I error rate and the power. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - CARDIOVASCULAR diseases
KW - CLINICAL drug trials
KW - CLINICAL medicine
KW - MEDICAL experimentation on humans
KW - PHARMACOLOGY
KW - BIOPHARMACEUTICS
KW - Active control trials
KW - Constancy condition
KW - Noninferiority margin
KW - Superiority margin
N1 - Accession Number: 24333862; Tsou, Hsiao-Hui 1; Email Address: chinfu@nhri.org.tw Hsiao, Chin-Fu 1 Chow, Shein-Chung 2 Yue, Lilly 3 Xu, Yunling 3 Lee, Shiowjen 3; Affiliation: 1: Division of Biostatistics and Bioinformatics, National Health Research Institutes. Zhunan Town, Miaoli County. Taiwan 2: Department of Biostatistics and Bioinformatics, Duke University Medical Center. Durham. North Carolina,Department of Statistics, National Cheng-Kung University. Tainan. Taiwan 3: CDRH, U.S. Food and Drug Administration. Rockville, Maryland. USA; Source Info: Apr2007, Vol. 17 Issue 2, p339; Subject Term: CLINICAL trials; Subject Term: CARDIOVASCULAR diseases; Subject Term: CLINICAL drug trials; Subject Term: CLINICAL medicine; Subject Term: MEDICAL experimentation on humans; Subject Term: PHARMACOLOGY; Subject Term: BIOPHARMACEUTICS; Author-Supplied Keyword: Active control trials; Author-Supplied Keyword: Constancy condition; Author-Supplied Keyword: Noninferiority margin; Author-Supplied Keyword: Superiority margin; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 19p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10543400601183861
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Julie M. Zito
AU - Daniel J. Safer
AU - Satish Valluri
AU - James F. Gardner
AU - James J. Korelitz
AU - Donald R. Mattison
T1 - Psychotherapeutic Medication Prevalence in Medicaid-Insured Preschoolers.
JO - Journal of Child & Adolescent Psychopharmacology
JF - Journal of Child & Adolescent Psychopharmacology
Y1 - 2007/04//
VL - 17
IS - 2
M3 - Article
SP - 195
EP - 204
SN - 10445463
AB - ObjectiveTo update knowledge of the prevalence of the use of psychotherapeutic medications in preschoolers with Medicaid insurance as requested by the Best Pharmaceuticals for Children Act of 2002 (BPCA).MethodPrescription, enrollment, and outpatient visit data from 7 state Medicaid programs were used to identify 274,518 youths continuously enrolled in 2001 and aged 2 to 4 on January 1, 2001. Annual prevalence of use was defined as one or more dispensed prescriptions for a psychotherapeutic medication and adjusted for anticonvulsant and anxiolyticsedativehypnotic use according to ICD-9 diagnostic groupings. Prevalence ratios adjusted for age, raceethnicity, and gender were estimated.Results2.30 (CI 2.24, 2.36) of preschoolers received one or more dispensings for a psychotherapeutic medication in 2001, approximately doubling the usage of comparable youth from 2 other state Medicaid programs studied in 1995. Boys were 2.4 times more likely than girls to receive psychotherapeutic medication. Whites were 4 times more likely than Hispanics and twice as likely as Blacks to receive medication for psychiatric or behavioral conditions. Since the mid-1990s, usage increased, especially for atypical antipsychotics and antidepressants. The prominent use of anticonvulsants (78.8) and anxiolyticsedativehypnotic drugs (91.4) in those with no psychiatric diagnosis, but with other medical diagnoses, shows that much use therein reflects treatment for seizures, rather than mood stabilization, and for minor medical conditions, rather than psychiatric disorders.ConclusionPreschool psychotherapeutic medication use increased across ages 2 to 4 for stimulants, antipsychotics, and antidepressants, reflecting use for psychiatricbehavioral disorders. However, the use of anxiolyticsedativehypnotics and anticonvulsants was more stable across these years, suggesting medical usage. Additional research to assess the benefits and risks of psychotherapeutic drugs is needed, particularly when such usage is off-label for both psychiatric and nonpsychiatric conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Child & Adolescent Psychopharmacology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIONAL health insurance
KW - MEDICAID
KW - MEDICARE
KW - ANTIPSYCHOTIC drugs
N1 - Accession Number: 25042363; Julie M. Zito 1 Daniel J. Safer 2 Satish Valluri 3 James F. Gardner 3 James J. Korelitz 4 Donald R. Mattison 5; Affiliation: 1: Department of Pharmaceutical Health Services Research, School of Pharmacy and Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland. 2: Johns Hopkins Medical Institutions, Departments of Psychiatry and Pediatrics, Baltimore, Maryland. 3: Department of Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore, Maryland. 4: Westat, 1650 Research Blvd., Rockville, Maryland. 5: U.S. Public Health Service, Obstetric and Pediatric Pharmacology Branch, National Institutes of Health, Bethesda, Maryland.; Source Info: Apr2007, Vol. 17 Issue 2, p195; Subject Term: NATIONAL health insurance; Subject Term: MEDICAID; Subject Term: MEDICARE; Subject Term: ANTIPSYCHOTIC drugs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dolan, Marc C.
AU - Dietrich, Gabrielle
AU - Panella, Nicholas A.
AU - Montenieri, John A.
AU - Karchesy, Joseph J.
T1 - Biocidal Activity of Three Wood Essential Oils Against Ixodes scapularis (Acari: Ixoclidae), Xenopsylla cheopis (Siphonaptera Pulicidae), and Aedes aegypti (Diptera: Culicidae).
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 2007/04//
VL - 100
IS - 2
M3 - Article
SP - 622
EP - 625
SN - 00220493
AB - The biocidal activity of three steam distilled wood essential oils--incense cedar, Calocedrus decurrens (Torr.) Florin; Port-Orford-cedar, Chamaecyparis lawsoniana (A. Murr.) Parl.; and western juniper, Juniperus occidentalis (Hook)—were evaluated against adult Aedes aegypti (L.) (Diptera: Culicidae) and Xenopsylla cheopis (Rothchild) (Siphonaptera: Pulicidae) and nymphal Ixodes scapularis Say (Acari: Ixodidae). In vitro laboratory bioassays were conducted to establish baseline dose-mortality data through 24 h. Incense cedar heartwood was the most toxic to all three vector species followed in order of activity by western juniper and Port-Orford-cedar based on LC50 and LC50 values. Ae. aegypti were substantially more susceptible to the oils than either I. scapularis or X. cheopis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic Entomology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological pest control
KW - Insect pests -- Control
KW - Biological control of insects
KW - Insect sterilization
KW - Pests -- Control
KW - Insects
KW - Entomology
KW - Insect baits & repellents
KW - Essences & essential oils
KW - Aedes aegypti
KW - biocidal
KW - essential oils
KW - Ixodes scapularis
KW - Xenopsylla cheopis
N1 - Accession Number: 25065128; Dolan, Marc C. 1; Email Address: mcd4@cdc.gov; Dietrich, Gabrielle 1; Panella, Nicholas A. 1; Montenieri, John A. 1; Karchesy, Joseph J. 2; Affiliations: 1: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, CO 80522; 2: Department of Wood Science and Engineering, Oregon State University, Corvallis, OR 97331; Issue Info: Apr2007, Vol. 100 Issue 2, p622; Thesaurus Term: Biological pest control; Thesaurus Term: Insect pests -- Control; Thesaurus Term: Biological control of insects; Thesaurus Term: Insect sterilization; Thesaurus Term: Pests -- Control; Thesaurus Term: Insects; Thesaurus Term: Entomology; Subject Term: Insect baits & repellents; Subject Term: Essences & essential oils; Author-Supplied Keyword: Aedes aegypti; Author-Supplied Keyword: biocidal; Author-Supplied Keyword: essential oils; Author-Supplied Keyword: Ixodes scapularis; Author-Supplied Keyword: Xenopsylla cheopis; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mainzer, Hugh
T1 - Veterinarians and Environmental Health Practitioners: Partners in Prevention.
JO - Journal of Environmental Health
JF - Journal of Environmental Health
Y1 - 2007/04//
VL - 69
IS - 8
M3 - Article
SP - 60
EP - 61
PB - National Environmental Health Association
SN - 00220892
AB - This article examines the role of veterinarians in environmental health in the United States. It is the author's belief that veterinarians have the training that gives them a unique capacity to address public health issues and help meet public health needs. The threat of anthrax, the spread of the West Nile virus and the importation of monkey pox are all places where veterinarian skills serve public health. In partnership with environmental health scientists, public health will be better protected. A list of services that veterinarians may supply to the field of environmental health is offered with examples of some typical activities.
KW - Veterinarians
KW - Environmental health
KW - West Nile virus
KW - Animals as carriers of disease
KW - Communicable diseases -- Transmission
KW - Anthrax
KW - Monkeypox
KW - Public health -- United States
KW - United States
N1 - Accession Number: 24551718; Mainzer, Hugh 1; Email Address: hugh.mainzer@cdc.hhs.gov; Affiliations: 1: Captain, Chief Veterinary Officer (select), U.S. Public Health Service, Supervisory Preventive Medicine Officer/Epidemiologist, Division of Emergency and Environmental Health Services, National Center for Environmental Health, CDC, 4770 Buford Highway, MS F-28, Atlanta, GA 30341; Issue Info: Apr2007, Vol. 69 Issue 8, p60; Thesaurus Term: Veterinarians; Thesaurus Term: Environmental health; Thesaurus Term: West Nile virus; Thesaurus Term: Animals as carriers of disease; Thesaurus Term: Communicable diseases -- Transmission; Subject Term: Anthrax; Subject Term: Monkeypox; Subject Term: Public health -- United States; Subject: United States; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1450
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Phillips, A. M. B.
AU - DePaola, A.
AU - Bowers, J.
AU - Ladner, S.
AU - Grimes, D. J.
T1 - An Evaluation of the Use of Remotely Sensed Parameters for Prediction of Incidence and Risk Associated with Vibrio parahaemolyticus in Gulf Coast Oysters (Crassostrea virginica).
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/04//
VL - 70
IS - 4
M3 - Article
SP - 879
EP - 884
SN - 0362028X
AB - The U.S. Food and Drug Administration recently published a Vibrio parahaemolyticus risk assessment for consumption of raw oysters that predicts V. parahaemolyticus densities at harvest based on water temperature. We retrospectively compared archived remotely sensed measurements (sea surface temperature, chlorophyll, and turbidity) with previously published data from an environmental study of V. parahaemolyticus in Alabama oysters to assess the utility of the former data for predicting V. parahaemolyticus densities in oysters. Remotely sensed sea surface temperature correlated well with previous in situ measurements (R² = 0.86) of bottom water temperature, supporting the notion that remotely sensed sea surface temperature data are a sufficiently accurate substitute for direct measurement. Turbidity and chlorophyll levels were not determined in the previous study, but in comparison with the V. parahaemolyticus data, remotely sensed values for these parameters may explain some of the variation in V. parahaemolyticus levels. More accurate determination of these effects and the temporal and spatial variability of these parameters may further improve the accuracy of prediction models. To illustrate the utility of remotely sensed data as a basis for risk management, predictions based on the U.S. Food and Drug Administration V. parahaemolyticus risk assessment model were integrated with remotely sensed sea surface temperature data to display graphically variations in V. parahaemolyticus density in oysters associated with spatial variations in water temperature. We believe images such as these could be posted in near real time, and that the availability of such information in a user-friendly format could be the basis for timely and informed risk management decisions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters -- Contamination
KW - Water temperature
KW - Shellfish as food -- Contamination
KW - Vibrio parahaemolyticus
KW - American oyster
KW - Alabama
KW - United States. Food & Drug Administration
N1 - Accession Number: 25022619; Phillips, A. M. B. 1; DePaola, A. 2; Bowers, J. 3; Ladner, S. 4; Grimes, D. J. 1; Email Address: jay.grimes@usm.edu; Affiliations: 1: University of Southern Mississippi, Gulf Coast Research Laboratory, Ocean Springs, Mississippi 39564; 2: Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528; 3: Food and Drug Administration, College Park, Maryland; 4: Planning Systems, Inc., Stennis Space Center, Mississippi 39529, USA; Issue Info: Apr2007, Vol. 70 Issue 4, p879; Thesaurus Term: Oysters -- Contamination; Thesaurus Term: Water temperature; Thesaurus Term: Shellfish as food -- Contamination; Subject Term: Vibrio parahaemolyticus; Subject Term: American oyster; Subject: Alabama ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 311710 Seafood Product Preparation and Packaging; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brzezinski, Jennifer L.
T1 - Detection of Sesame Seed DNA in Foods Using Real-Time PCR.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/04//
VL - 70
IS - 4
M3 - Article
SP - 1033
EP - 1036
SN - 0362028X
AB - The detection of potentially allergenic foods, such as sesame seeds, in food products is a major concern for the food-processing industry. A real-time PCR method was designed to determine if sesame seed DNA is present in food products. The PCR reaction amplifies a 66-bp fragment of the sesame seed 2S albumin gene, which is detected with a sesame-specific, dual-labeled TaqMan probe. This reaction will not amplify DNA derived from other seeds present in baked goods, such as pumpkin, poppy, and sunflower seeds. Additionally, this assay will not cross-react with DNA from several tree nut species, such as almond, Brazil nut, cashew, hazelnut, and walnut, as well as four varieties of peanut. This assay is sensitive enough to detect 5 pg of purified sesame seed DNA, as well as sesame seed DNA in a spiked wheat cracker sample. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Sesame
KW - Oilseed plants
KW - DNA
KW - Polymerase chain reaction
KW - Albumins
N1 - Accession Number: 25022644; Brzezinski, Jennifer L. 1; Email Address: jennifer.brzezinski@fda.gov; Affiliations: 1: U.S. Food and Drug Administration. Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, Ohio 45237-3097, USA; Issue Info: Apr2007, Vol. 70 Issue 4, p1033; Thesaurus Term: RESEARCH; Subject Term: Sesame; Subject Term: Oilseed plants; Subject Term: DNA; Subject Term: Polymerase chain reaction; Subject Term: Albumins; NAICS/Industry Codes: 111120 Oilseed (except Soybean) Farming; NAICS/Industry Codes: 111191 Oilseed and Grain Combination Farming; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
T1 - Chromium in Stainless Steel Welding Fume Suppresses Lung Defense Responses Against Bacterial Infection in Rats.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2007/04//Apr-Jun2007
VL - 4
IS - 2
M3 - Article
SP - 117
EP - 127
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine which metal component of MMA-SS welding fume alters lung defense responses. At Day 0, rats were intratracheally instilled one time with saline or MMA-SS at a concentration of 2 mg/rat. Additional rats were treated with the metal constituents, Fe2O3, NiO, or Cr2Na2O7 alone or in combination, at concentrations that are present in the dose used for MMA-SS treatment. At Day 3, rats were intratracheally inoculated with 5 × 103 Listeria monocytogenes. At Days 6, 8 and 10, homogenized left lungs were cultured, and colony-forming units were counted after an overnight incubation to assess pulmonary bacterial clearance. At Day 3 (prior to infection) and at Days 6, 8 and 10, right lungs were lavaged to recover cells and fluid from the airspaces to measure lung injury, inflammation, and cytokine secretion. The production of reactive oxygen species by phagocytes recovered from the lungs was measured. Exposure to MMA-SS, soluble Cr, or the mixture of all three metals before infection significantly increased bacterial lung burden and tissue damage when compared to control. Animals treated with NiO or Fe2O3 did not differ from control. Animals pre-treated with soluble Cr had alterations in inflammation and in the production of different cytokines (TNFα, IL-6, IL-2, and IL-12) involved in lung immune responses. This study indicates that soluble Cr present in MMA-SS is likely the primary component responsible for the suppression of lung defense responses associated with stainless steel welding fumes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Lung diseases
KW - Disease susceptibility
KW - Cytokines
KW - Welding fumes
KW - chromium
KW - iron oxide
KW - Listeria monocytogenes
KW - welding fume
N1 - Accession Number: 25346825; Antonini, James M. 1; Email Address: jga6@cdc.gov; Roberts, Jenny R. 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Apr-Jun2007, Vol. 4 Issue 2, p117; Thesaurus Term: Bacterial diseases; Subject Term: Lung diseases; Subject Term: Disease susceptibility; Subject Term: Cytokines; Subject Term: Welding fumes; Author-Supplied Keyword: chromium; Author-Supplied Keyword: iron oxide; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: welding fume; Number of Pages: 11p; Illustrations: 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1080/15476910701336953
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106286735
T1 - Improving the quality of nursing care using the Medical Expenditure Panel Survey data.
AU - Hughes RG
AU - Clancy CM
Y1 - 2007/04//Apr-Jun2007
N1 - Accession Number: 106286735. Language: English. Entry Date: 20070518. Revision Date: 20150818. Publication Type: Journal Article; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9200672.
KW - Quality of Nursing Care
KW - Surveys
KW - United States Agency for Healthcare Research and Quality
SP - 93
EP - 96
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 22
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, Rockville, Md.
U2 - PMID: 17353742.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106171400
T1 - Occupational noise levels during emergency relief operations in the aftermath of Hurricane Katrina.
AU - Achutan C
A2 - Mazzuckelli L
Y1 - 2007/04//
N1 - Accession Number: 106171400. Language: English. Entry Date: 20071019. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Emergencies -- Epidemiology
KW - Natural Disasters
KW - Noise
KW - Occupational Exposure
KW - Rescue Work
KW - Humanitarian Aid -- Methods
SP - D33
EP - 5
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health. Cincinnati, Ohio.
U2 - PMID: 17365492.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Erin C. McCanlies
AU - Schuler, Christine R.
AU - Kreiss, Kathleen
AU - Frye, Bonnie L.
AU - Ensey, James S.
AU - Weston, Ainsley
T1 - TNF-α Polymorphisms in Chronic Beryllium Disease and Beryllium Sensitization.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/04//
VL - 49
IS - 4
M3 - Article
SP - 446
EP - 452
SN - 10762752
AB - The article presents information about a study aimed to explore the possible association between chronic beryllium disease, beryllium sensitivity and tumor necrosis factor-alpha polymorphisms at the promoter regions -238 and -308. Participants in the study were workers from a large beryllium manufacturing company. A questionnaire on medical and work history was given to all participants to complete. They also gave blood sample for genetic analyses. The blood beryllium lymphocyte proliferation test was used to screen the study participants not known to have beryllium sensitization.
KW - TUMOR necrosis factor
KW - GENETIC polymorphisms
KW - PROMOTERS (Genetics)
KW - GENETIC transcription
KW - NUCLEOTIDES
KW - BERYLLIUM
KW - GLYCOPROTEINS
KW - GROWTH factors
KW - LYMPHOCYTES
N1 - Accession Number: 24880321; Erin C. McCanlies 1; Email Address: EIM4@CDC.GOV Schuler, Christine R. 2 Kreiss, Kathleen 2 Frye, Bonnie L. 1 Ensey, James S. 1 Weston, Ainsley 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.; Source Info: Apr2007, Vol. 49 Issue 4, p446; Subject Term: TUMOR necrosis factor; Subject Term: GENETIC polymorphisms; Subject Term: PROMOTERS (Genetics); Subject Term: GENETIC transcription; Subject Term: NUCLEOTIDES; Subject Term: BERYLLIUM; Subject Term: GLYCOPROTEINS; Subject Term: GROWTH factors; Subject Term: LYMPHOCYTES; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 7p; Document Type: Article
L3 - 10.1097/JOM.0b013e31803b9499
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24880321&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106128561
T1 - Tobacco smoking by occupation in Australia: results from the 2004 to 2005 National Health Survey.
AU - Smith DR
AU - Leggat PA
Y1 - 2007/04//
N1 - Accession Number: 106128561. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Occupations and Professions
KW - Smoking -- Epidemiology -- Australia
KW - Adult
KW - Age Factors
KW - Australia
KW - Descriptive Statistics
KW - Employment Status
KW - Female
KW - Interviews
KW - Male
KW - Middle Age
KW - Sex Factors
KW - Human
SP - 437
EP - 445
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 49
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: This study presents the most recent estimates of Australia's national tobacco smoking rates by occupation. METHODS: Smoking data was extracted from the 2004 to 2005 National Health Survey, which captured approximately 26,000 persons and achieved a response rate of around 90%. Participants were limited to those of working age (18 to 64 years), with data stratified by job category and gender during the analysis. RESULTS: The prevalence of smoking among Australian workers is estimated to be 25% (28% among males and 21% among females). Tobacco usage is considerably less common among those who are employed compared with the unemployed. By job category, smoking was most common among laborers and the least common among professionals, managers, or administrators. CONCLUSIONS: Overall, this study suggests that Australian rates of tobacco smoking vary widely depending on occupation. Effective tobacco-control strategies targeting vulnerable sections of the workforce, particularly blue-collar workers, are clearly needed.
SN - 1076-2752
AD - International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan
U2 - PMID: 17426527.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106128561&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106128562
T1 - TNF-alpha polymorphisms in chronic beryllium disease and beryllium sensitization.
AU - McCanlies EC
AU - Schuler CR
AU - Kreiss K
AU - Frye BL
AU - Ensey JS
AU - Weston A
Y1 - 2007/04//
N1 - Accession Number: 106128562. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Beryllium -- Adverse Effects
KW - Occupational Diseases -- Epidemiology
KW - Polymorphism, Genetic
KW - Tumor Necrosis Factor
KW - Alleles
KW - Beryllium -- Blood
KW - Chi Square Test
KW - Confidence Intervals
KW - DNA
KW - Fisher's Exact Test
KW - Logistic Regression
KW - Odds Ratio
KW - Questionnaires
KW - Human
SP - 446
EP - 452
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 49
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine involved in normal immune functions. The aim of this study was to investigate if there is an association between chronic beryllium disease or beryllium sensitization and two variants of the TNF-alpha gene located at -308 and -238 called TNF-alpha-308*02 and TNF-alpha-238*02. METHODS: TNF-alpha-308 and TNF-alpha-238 genotyping was conducted in a large, population-based cohort consisting of 886 beryllium workers (92 individuals with chronic beryllium disease, 64 who were beryllium sensitized, and 730 individuals without sensitization or disease). RESULTS: The odds of chronic beryllium disease in the presence of at least one TNF-alpha-308*02 or TNF-alpha-238*02 allele was not significant (OR=1.0; 95% CI=0.7, 1.7 and OR=0.8; 95% CI=0.4, 1.6). This was true regardless of whether a worker was homozygous or heterozygous for TNF-alpha-308*02 or TNF-alpha-238*02. Similarly, neither allele was associated with sensitization (P>0.05). CONCLUSIONS: Unlike an earlier report, there was no association between these specific TNF-alpha alleles and either chronic beryllium disease or sensitization to beryllium.
SN - 1076-2752
AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
U2 - PMID: 17426528.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Midha, Kamal K.
AU - Shah, Vinod P.
AU - Singh, Gur Jai Pal
AU - Patnaik, Rabi
T1 - Conference report: Bio-International 2005.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/04//
VL - 96
IS - 4
M3 - Article
SP - 747
EP - 754
SN - 00223549
AB - This is a summary report of the International Pharmaceutical Federation/Board of Pharmaceutical Sciences (FIP/BPS) international conference, Bio-International 2005, which was held October 24–26, 2005 at the Royal Pharmaceutical Society, in London, UK. Bioequivalence (BE) issues related to multisource locally delivered topical dosage forms, oral inhalation drug products, highly variable drug products (HVDP), and endogenously occurring drugs were discussed. The conference also focused on alternate approaches to assess BE for some of these drug products. Pharmacokinetic (PK) approaches like, dermatopharmacokinetics (DPK) for dermatological topical dosage forms, scaled average BE (s-ABE) where within-subject variability is considered for estimation of 90% confidence intervals to document BE for highly variable drugs (HVD) were recommended. In addition, issues and difficulties related to the BE assessment of oral inhalation products, role, and appropriateness of metabolites in BE assessment, importance of base line correction in BE assessment of endogenously occurring drugs, and waiver of BE study requirements for certain drugs based on a Biopharmaceutics Classification System (BCS), were also discussed. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 747–754, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOLOGY
KW - BIOPHARMACEUTICS
KW - DRUGS -- Therapeutic equivalency
KW - METABOLITES
KW - DRUG delivery systems
KW - PHARMACOKINETICS
KW - bioavailability
KW - bioequivalence
KW - Biopharmaceutics Classification System
KW - regulatory science
KW - transdermal
N1 - Accession Number: 24239921; Midha, Kamal K. 1,2; Email Address: midha@pharmalytics.ca Shah, Vinod P. 3 Singh, Gur Jai Pal 4 Patnaik, Rabi 5; Affiliation: 1: College of Pharmacy and Medicine, University of Saskatchewan, Saskatoon, SK, Canada 2: Pharmalytics Inc., Saskatoon, SK, Canada 3: International Pharmaceutical Federation (FIP) Scientific Secretary, North Potomac, Maryland 4: Division of Bioequivalence, United States Food and Drug Administration, Rockville, Maryland 5: Watson Laboratories, Corona, California; Source Info: Apr2007, Vol. 96 Issue 4, p747; Subject Term: PHARMACOLOGY; Subject Term: BIOPHARMACEUTICS; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: METABOLITES; Subject Term: DRUG delivery systems; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: bioavailability; Author-Supplied Keyword: bioequivalence; Author-Supplied Keyword: Biopharmaceutics Classification System; Author-Supplied Keyword: regulatory science; Author-Supplied Keyword: transdermal; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/jps.20786
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - Group velocity, phase velocity, and dispersion in human calcaneus in vivo.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2007/04//
VL - 121
IS - 4
M3 - Article
SP - 2431
EP - 2437
SN - 00014966
AB - Commercial bone sonometers measure broadband ultrasonic attenuation and/or speed of sound (SOS) in order to assess bone status. Phase velocity, which is usually measured in frequency domain, is a fundamental material property of bone that is related to SOS, which is usually measured in time domain. Four previous in vitro studies indicate that phase velocity in human cancellous bone decreases with frequency (i.e., negative dispersion). In order to investigate frequency-dependent phase velocity in vivo, through-transmission measurements were performed in 73 women using a GE Lunar Achilles Insight® commercial bone sonometer. Average phase velocity at 500 kHz was 1489±55 m/s (mean ± standard deviation). Average dispersion rate was -59±52 m/sMHz. Group velocity was usually lower than phase velocity, as is expected for negatively dispersive media. Using a stratified model to represent cancellous bone, the reductions in phase velocity and dispersion rate in vivo as opposed to in vitro can be explained by (1) the presence of marrow instead of water as a fluid filler, and (2) the decreased porosity of bones of living (compared with deceased) subjects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE
KW - ULTRASONIC waves -- Attenuation
KW - SPEED of sound
KW - ATTENUATION (Physics)
KW - SPEED
N1 - Accession Number: 24560866; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Apr2007, Vol. 121 Issue 4, p2431; Subject Term: BONE; Subject Term: ULTRASONIC waves -- Attenuation; Subject Term: SPEED of sound; Subject Term: ATTENUATION (Physics); Subject Term: SPEED; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1121/1.2697436
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mossoba, M. M.
AU - Kramer, J. K. G.
AU - Milosevic, V.
AU - Milosevic, M.
AU - Azizian, H.
T1 - Interference of Saturated Fats in the Determination of Low Levels of trans Fats (below 0.5%) by Infrared Spectroscopy.
JO - Journal of the American Oil Chemists' Society (JAOCS)
JF - Journal of the American Oil Chemists' Society (JAOCS)
Y1 - 2007/04//
VL - 84
IS - 4
M3 - Article
SP - 339
EP - 342
SN - 0003021X
AB - The mandate to label food products with the content of total trans fatty acids has led to an increase in demand for sensitive and accurate methodologies for the rapid quantitation of trans fats. Unfortunately, the latest official infrared (IR) spectroscopic method lacks the required sensitivity. A more sensitive IR procedure that requires the measurement of the height of the second derivative (2D) of the trans absorption band at 966 cm-1 was recently proposed; however, a reported inconsistency at low trans levels between GC (0% of total fat) and IR (1.2% of total fat) results for a fully hydrogenated vegetable oil could not be reconciled, and triggered further investigations. For the first time, we recognize and report the presence of weak interference bands (962-956 cm-1) attributed to saturated fats in the IR spectra of trans fats; these interference bands have an adverse impact on the sensitivity and accuracy of the IR determination at low trans levels (£0.5% of total fat). Therefore, weak spectral features observed at energies below the one expected for trans bands (966 cm-1) in test samples high in saturated fat (coconut oil and cocoa butter) must not be mistaken for trans bands. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Oil Chemists' Society (JAOCS) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - LAW & legislation
KW - TRANS fatty acids
KW - STEREOISOMERS
KW - INFRARED spectroscopy
KW - COCONUT oil
N1 - Accession Number: 24701801; Mossoba, M. M. 1; Email Address: magdi.mossoba@fda.hhs.gov; Kramer, J. K. G. 2; Milosevic, V. 3; Milosevic, M. 3; Azizian, H. 4; Affiliations: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-717, Room BE-012, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; 2: Agriculture and Agri-Food Canada, Guelph, ON, Canada; 3: MeV Photonics, Westport, CT, USA; 4: NIR Technologies, Oakville, ON, Canada; Issue Info: Apr2007, Vol. 84 Issue 4, p339; Thesaurus Term: FOOD labeling; Subject Term: LAW & legislation; Subject Term: TRANS fatty acids; Subject Term: STEREOISOMERS; Subject Term: INFRARED spectroscopy; Subject Term: COCONUT oil; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; Number of Pages: 4p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1007/s11746-007-1038-4
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Tami, Cecilia
AU - Silberstein, Erica
AU - Manangeeswaran, Mohanraj
AU - Freeman, Gordon J.
AU - Umetsu, Sarah E.
AU - DeKruyff, Rosemarie H.
AU - Umetsu, Dale T.
AU - Kaplan, Gerardo G.
T1 - Immunoglobulin A (IgA) Is a Natural Ligand of Hepatitis A Virus Cellular Receptor 1 (HAVCR1), and the Association of IgA with HAVCR1 Enhances Virus-Receptor Interactions.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2007/04//
VL - 81
IS - 7
M3 - Article
SP - 26
EP - 26
SN - 0022538X
AB - The hepatitis A virus cellular receptor 1 (HAVCR1/TIM1), a member of the T-cell immunoglobulin mucin (TIM) family, is an important atopy susceptibility gene in humans. The exact natural function of HAVCR1/TIM1 and the inverse association between HAV infection and prevention of atopy are not well understood. To identify natural ligands of human HAVCR1/TIM1, we used an expression cloning strategy based on the binding of dog cells transfected with a human lymph node cDNA library to a HAVCR1/TIM1 Fc fusion protein. The transfected cells that bound to the human HAVCR1/TIM1 Fc contained cDNA of human immunoglobulin alpha 1 heavy (Igα1) and lambda light (Igλ) chain and secreted human IgA1λ antibody that bound to the cell surface. Cotransfection of the isolated Igα1 and Igλ cDNAs to naïve dog cells resulted in the secretion of IgA1λ that bound to HAVCR1/TIM1 Fc but not to a poliovirus receptor Fc fusion protein in a capture enzyme-linked immunosorbent assay. The interaction of HAVCR1/TIM1 with IgA was inhibited by monoclonal antibodies (MAbs) against Igα1 and Igλ, excess IgA1λ, or anti-HAVCR1/TIM1 MAb. IgA did not inhibit HAV infection of African green monkey cells, suggesting that the IgA and the virus binding sites are in different epitopes on HAVCR1/TIM1. IgA enhanced significantly the neutralization of HAV by HAVCR1/TIM1 Fc. Our results indicate that IgA1λ is a specific ligand of HAVCR1/TIM1 and that their association has a synergistic effect in virus-receptor interactions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS A virus
KW - T cells
KW - IMMUNOGLOBULINS
KW - LYMPH nodes
KW - ENTEROVIRUSES
KW - LYMPHOCYTES
N1 - Accession Number: 24468902; Tami, Cecilia 1 Silberstein, Erica 1 Manangeeswaran, Mohanraj 1 Freeman, Gordon J. 2 Umetsu, Sarah E. 3 DeKruyff, Rosemarie H. 4 Umetsu, Dale T. 4 Kaplan, Gerardo G. 1; Email Address: GK@helix.nih.gov; Affiliation: 1: Laboratory of Hepatitis and Related Emerging Agents, CBER, Food and Drug Administration, Bethesda, Maryland 20892 2: Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 3: Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 4: Division of Immunology, Karp Laboratories, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115; Source Info: Apr2007, Vol. 81 Issue 7, p26; Subject Term: HEPATITIS A virus; Subject Term: T cells; Subject Term: IMMUNOGLOBULINS; Subject Term: LYMPH nodes; Subject Term: ENTEROVIRUSES; Subject Term: LYMPHOCYTES; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.01585-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106295472
T1 - Modifying DRG-PPS to include only diagnoses present on admission: financial implications and challenges.
AU - Zhan C
AU - Elixhauser A
AU - Friedman B
AU - Houchens R
AU - Chiang Y
Y1 - 2007/04//2007 Apr
N1 - Accession Number: 106295472. Language: English. Entry Date: 20070601. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Iezzoni LI. Finally present on admission but needs attention. (MED CARE) 2007 Apr; 45 (4): 280-282. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Coding -- Trends
KW - Diagnosis
KW - Diagnosis-Related Groups
KW - Medicare -- Economics
KW - Patient Admission
KW - Prospective Payment System
KW - Descriptive Statistics
KW - Human
SP - 288
EP - 291
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: The inability to distinguish complications acquired in hospital from comorbid conditions that are present on admission (POA) has long hampered the use of claims data in quality and safety research. Now pay-for-performance initiatives and legislation requiring Medicare to reduce payment for acquired infections add imperative for POA coding. This study used data from 2 states currently coding POA to assess the financial impact if Medicare pays based on POA conditions only and to examine the challenges in implementing POA coding.Methods: Medicare payments were calculated based first on all diagnoses and then on POA diagnoses in the Medicare discharge abstracts from California and New York in 2003, using the Diagnosis Related Group (DRG)-based Prospective Payment System (PPS) formula. The potential savings that result from excluding non-POA diagnoses were calculated. Patterns of POA coding were explored.Results: Medicare could have saved $56 million in California, $51 million in New York, and $800 million nationwide in 2003 had it paid hospital claims based only on POA diagnoses. Approximately 15% of the claims had non-POA codes, but only 1.4% of the claims were reassigned to lower-cost DRGs after excluding non-POA diagnoses. Excluding non-POA diagnoses resulted in reduced payment for operating costs, but increased outlier payments because some of the claims were designated as 'unusually high cost' in the lower-cost DRGs. POA coding patterns suggest some problems in current POA coding.Conclusions: To be consistent with pay-for-performance principles and make claims data more useful for quality assurance, incorporating POA coding into DRG-PPS could produce sizable savings for Medicare.
SN - 0025-7079
AD - Agency for Healthcare Research and Quality, Dept of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; Chunliu.zhan@ahrq.hhs.gov
U2 - PMID: 17496711.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Takahashi, Yukio
T1 - A consideration of the relationship between subjective unpleasantness and body surface vibrations induced by high-level, complex lowfrequency noise.
JO - Noise Notes
JF - Noise Notes
Y1 - 2007/04//
VL - 6
IS - 2
M3 - Article
SP - 7
EP - 19
PB - Multi-Science Publishing Co Ltd
SN - 14754738
AB - To investigate the relationship between subjective unpleasantness and body surface vibrations induced by high-level, complex low-frequency noise, we carried out two experiments. Body surface vibrations were measured at the right and left anterior chest and the right and left anterior abdomen of male subjects. Subjective unpleasantness was rated on a scale of 1 to 5, and correlated with the vibration acceleration levels (VALs) of the vibrations measured on the body surface. As a result, it was found that the ratings of unpleasantness did, on the whole, significantly correlate with the VALs. In addition, we estimated the frequency-weightings for the VAL to optimize the correlation with the rating of unpleasantness. Based on a reasonable hypothesis, the frequency-weightings estimated in the present study were considered to be consistent with those estimated in our previous study using low-frequency pure tones. The present results support the idea that not only the loudness of a noise, but also the vibrations induced by that noise, contribute to the subjective unpleasantness experienced by persons exposed to high-level low-frequency noise. The effect of vibration should be taken into consideration in evaluating high-level low-frequency noise. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Notes is the property of Multi-Science Publishing Co Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Noise control
KW - Noise
KW - Vibration (Mechanics)
KW - Frequencies of oscillating systems
KW - Correlation (Statistics)
KW - Body surface vibration
KW - Complex low-frequency noise
KW - High sound pressure levels
KW - Low-frequency noise
KW - Subjective unpleasantness
N1 - Accession Number: 26045908; Takahashi, Yukio 1; Email Address: takahay@h.jniosh.go.jp; Affiliations: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, Japan. 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan.; Issue Info: Apr2007, Vol. 6 Issue 2, p7; Thesaurus Term: RESEARCH; Thesaurus Term: Noise control; Subject Term: Noise; Subject Term: Vibration (Mechanics); Subject Term: Frequencies of oscillating systems; Subject Term: Correlation (Statistics); Author-Supplied Keyword: Body surface vibration; Author-Supplied Keyword: Complex low-frequency noise; Author-Supplied Keyword: High sound pressure levels; Author-Supplied Keyword: Low-frequency noise; Author-Supplied Keyword: Subjective unpleasantness; Number of Pages: 13p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Wyeth, Jo
AU - Green, Lanh
AU - Avigan, Mark
T1 - U.S. Food and Drug Administration Analysis of Strokes Associated With Raloxifene.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2007/04//
VL - 109
IS - 4
M3 - Letter
SP - 999
EP - 999
SN - 00297844
AB - A letter to the editor is presented concerning the response of the United States Food and Drug Administration to the occurrence of strokes associated with Raloxifene.
KW - LETTERS to the editor
KW - RALOXIFENE
N1 - Accession Number: 24924620; Wyeth, Jo 1 Green, Lanh 1 Avigan, Mark 1; Affiliation: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland; Source Info: Apr2007, Vol. 109 Issue 4, p999; Subject Term: LETTERS to the editor; Subject Term: RALOXIFENE; Number of Pages: 2/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106299309
T1 - Persistent socioeconomic disparities in infant, neonatal, and postneonatal mortality rates in the United States, 1969-2001.
AU - Singh GK
AU - Kogan MD
Y1 - 2007/04//
N1 - Accession Number: 106299309. Language: English. Entry Date: 20070608. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Attitude to Health
KW - Cause of Death
KW - Infant Mortality -- Trends
KW - Maternal Behavior -- Ethnology
KW - Blacks
KW - Confidence Intervals
KW - Cox Proportional Hazards Model
KW - Data Analysis Software
KW - Educational Status
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Linear Regression
KW - Male
KW - Multivariate Analysis
KW - Prenatal Care
KW - Relative Risk
KW - Risk Assessment
KW - Socioeconomic Factors
KW - United States
KW - Vital Statistics
KW - Whites
KW - Human
SP - e928
EP - 39
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 119
IS - 4
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: This study examines changing patterns of inequalities in US infant, neonatal, and postneonatal mortality rates between 1969 and 2001 by area deprivation and maternal education. METHODS: A deprivation index was linked to county vital records data to derive annual infant mortality rates by deprivation quintiles from 1969 to 2000. Rates by maternal education were computed for 1986, 1991, 1996, and 2001 using national linked birth/infant death files. Log-binomial regression was used to estimate relative risks of infant mortality by deprivation and time period. Cox regression was used to model overall and birth weight-specific infant mortality risks by maternal education after adjusting for covariates. Temporal disparities were summarized by log-linear regression and inequality indices. RESULTS: Although absolute disparities have narrowed over time, relative socioeconomic disparities in infant mortality have increased since 1985. In 1985-1989, infants in the most deprived group had, respectively, 36% and 57% higher risks of neonatal and postneonatal mortality than infants in the least deprived group. The corresponding relative risks increased to 43% and 96% in 1995-2000. The adjusted risk of infant mortality was 22% higher in 1986 for mothers with < 12 years of education than for those with > or = 16 years of education, with the relative risk increasing to 41% in 2001. Disparities were greatest among normal birth weight infants, with education-specific relative risks of neonatal and postneonatal mortality increasing significantly between 1986 and 2001. CONCLUSIONS: Dramatic declines in infant mortality among all of the socioeconomic groups during 1969-2001 represent a major public health success. However, substantial socioeconomic disparities persisted in both neonatal and postneonatal mortality. Relatively larger declines in infant and postneonatal mortality among higher socioeconomic groups have contributed to the widening gap in mortality since 1985. Persistent disparities in infant mortality may reflect increasing polarization among socioeconomic groups in material and social conditions, smoking during pregnancy, and health care services.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers La, Room 18-41, Rockville, MD 20857, USA. gsingh@hrsa.gov
U2 - PMID: 17403832.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106299309&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Abdolpour, Farid
AU - Shahverdi, Ahmad-Reza
AU - Rafii, Fatemeh
AU - Fazeli, Mohammad-Reza
AU - Amini, Mohsen
T1 - Effects of Piperitone on the Antimicrobial Activity of Nitrofurantoin and on Nitrofurantoin Metabolism by Enterobacter cloacae.
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
Y1 - 2007/04//
VL - 45
IS - 3
M3 - Article
SP - 230
EP - 234
PB - Taylor & Francis Ltd
SN - 13880209
AB - Monoterpenes, including piperitone, increase nitrofurantoin susceptibility in members of the family Enterobacteriaceae. To understand interactions of these compounds, a nitrofurantoin-resistant clinical strain of Enterobacter cloacae was subjected to two-dimensional checkerboard dilutions of piperitone and nitrofurantoin. Synergy was demonstrated with all combinations of these compounds. HPLC analysis showed that E. cloacae metabolized nitrofurantoin to compounds that were not detectable by chromatography with UV detection and lacked bactericidal activity. E. cloacae produced a cell-associated nitroreductase, whose activity was reduced by piperitone in a dose-dependent manner. More than one mechanism may be involved in the synergistic interaction of these compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOTERPENES
KW - TERPENES
KW - ENTEROBACTERIACEAE
KW - GRAM-negative bacteria
KW - BIOCHEMISTRY
KW - Metabolism
KW - nitrofurantoin
KW - nitroreductase
KW - piperitone
KW - synergism
N1 - Accession Number: 24904323; Abdolpour, Farid 1 Shahverdi, Ahmad-Reza 1; Email Address: shahverd@sina.tums.ac. Rafii, Fatemeh 2 Fazeli, Mohammad-Reza 3 Amini, Mohsen 4; Affiliation: 1: Department of Pharmaceutical Biotechnology and Biotechnology Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran. Tehran. Iran 2: National Center for Toxicological Research, U.S. Food and Drug Administration. Jefferson, Arkansas. USA 3: Department of Food and Drug Control, Faculty of Pharmacy, Medical Sciences/University of Tehran. Tehran. Iran 4: Department of Medicinal Chemistry, Faculty of Pharmacy, Medical Sciences/University of Tehran. Tehran. Iran; Source Info: Apr2007, Vol. 45 Issue 3, p230; Subject Term: MONOTERPENES; Subject Term: TERPENES; Subject Term: ENTEROBACTERIACEAE; Subject Term: GRAM-negative bacteria; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: nitrofurantoin; Author-Supplied Keyword: nitroreductase; Author-Supplied Keyword: piperitone; Author-Supplied Keyword: synergism; Number of Pages: 5p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/13880200701213161
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24904323&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105929230
T1 - Aripiprazole as the causative agent of neuroleptic malignant syndrome: a case report.
AU - Molina D
AU - Tingle LE
AU - Lu X
Y1 - 2007/04//
N1 - Accession Number: 105929230. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; case study; letter. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Special Interest: Psychiatry/Psychology. NLM UID: 100887410.
KW - Clozapine -- Adverse Effects
KW - Fecal Incontinence -- Chemically Induced
KW - Urinary Incontinence -- Chemically Induced
KW - Adult
KW - Clozapine -- Administration and Dosage
KW - Male
SP - 148
EP - 150
JO - Primary Care Companion to the Journal of Clinical Psychiatry
JF - Primary Care Companion to the Journal of Clinical Psychiatry
JA - PRIM CARE COMPANION J CLIN PSYCHIATRY
VL - 9
IS - 2
CY - Memphis, Tennessee
PB - Physicians Postgraduate Press
SN - 1523-5998
AD - United States Public Health Service.
U2 - PMID: 17607339.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105929230&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, Steven A.
AU - Menis, Mikhail
AU - O'Connell, Kathryn
AU - Burwen, Dale R.
T1 - Blood use by inpatient elderly population in the United States.
JO - Transfusion
JF - Transfusion
Y1 - 2007/04//
VL - 47
IS - 4
M3 - Article
SP - 582
EP - 592
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Our objective was to characterize inpatient blood use by the US elderly population during 2001. As the US population ages the demand for blood is expected to grow. There have been no comprehensive studies, however, detailing blood use by the elderly in the United States. STUDY DESIGN AND METHODS: A descriptive cross-sectional study of blood utilization was conducted with the 5 percent Medicare Provider Analysis and Review (MedPAR) data file obtained from the Centers for Medicare and Medicaid Services (CMS). Each record of the file represented a billing record of an inpatient stay. Blood use was identified by either a nonzero blood pints furnished quantity or a procedure code for transfusion of whole blood or red blood cells (RBCs). RESULTS: Among 635,700 stays, 43,220 (6.8%) recorded transfusion of whole blood or RBCs. Blood use prevalence was approximately 4.5 times higher for stays with at least one medical procedure compared to stays without procedures. Of 15,579 stays with number of blood pints furnished recorded, the top 20 principal procedures with the largest quantities of blood accounted for about 56 percent of total blood pints furnished; however, these procedures represented only about 19 percent of all stays. CONCLUSION: Our study shows a strong association between medical procedures and blood use among inpatient stays for the elderly. Some of the highest blood utilization occurred with surgical procedures. More precise information on blood utilization may serve as the basis for estimating risks associated with blood transfusion and may inform decisions that maintain an adequate supply of blood. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD transfusion
KW - OLDER people
KW - ERYTHROCYTES
KW - MEDICARE
KW - MEDICAID
KW - TRACHEOTOMY
KW - BLOOD platelets
N1 - Accession Number: 24410015; Anderson, Steven A. 1; Email Address: anderson@fda.hhs.gov Menis, Mikhail 1 O'Connell, Kathryn 1 Burwen, Dale R. 1; Affiliation: 1: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: Apr2007, Vol. 47 Issue 4, p582; Subject Term: BLOOD transfusion; Subject Term: OLDER people; Subject Term: ERYTHROCYTES; Subject Term: MEDICARE; Subject Term: MEDICAID; Subject Term: TRACHEOTOMY; Subject Term: BLOOD platelets; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 11p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1537-2995.2007.01159.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24410015&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tesfamariam, Belay
AU - DeFelice, Albert F.
T1 - Endothelial injury in the initiation and progression of vascular disorders
JO - Vascular Pharmacology
JF - Vascular Pharmacology
Y1 - 2007/04//
VL - 46
IS - 4
M3 - Article
SP - 229
EP - 237
SN - 15371891
AB - Abstract: Endothelial cell dysfunction is considered to be an early event which subsequently leads to vascular wall disorders. Ultrastructural studies indicate that the endothelial cell changes involve membrane damage, increased permeability, swelling and necrosis. The endothelial cell loss of function could be as a result of changes in hemodynamic forces (shear and/or hoop stress), direct drug-induced cytotoxicity, mechanical device implant-induced injury and/or immune-mediated mechanisms. Drugs may perturb endothelial cell integrity by directly triggering inflammatory signaling cascades, enhancing expression of cellular adhesion molecules, activation of cytotoxic T cells and/or autoantibodies directed against endothelial cell membranes. Local release of inflammatory cytokines and chemokines activate endothelial cells to upregulate soluble adhesion molecules, activate neutrophils and generate reactive oxygen species which serve to amplify the initial inflammation leading to dysregulated apoptosis, secondary necrosis and overt vascular injury lesions. Considering the role of the endothelium in the initiation and propagation of vascular wall injury, there is a need for the discovery of validated biomarkers to serve as a predictor of activation of inflammatory cascades in the development of vascular injury. This article reviews some aspects of the multifaceted mechanisms that lead to the initial endothelial cell disruption and subsequent vascular wall injury. [Copyright &y& Elsevier]
AB - Copyright of Vascular Pharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOTHELIUM
KW - CELLULAR pathology
KW - ULTRASTRUCTURE (Biology)
KW - HEMODYNAMICS
KW - CELL-mediated cytotoxicity
KW - WOUNDS & injuries
KW - DRUGS -- Physiological effect
KW - INFLAMMATION -- Mediators
KW - Adhesion molecules
KW - Biomarkers
KW - Drugs
KW - Endothelium
KW - Free radicals
KW - Immune reactions
KW - Vasculitis
N1 - Accession Number: 23808045; Tesfamariam, Belay; Email Address: belay.tesfamariam@fda.hhs.gov DeFelice, Albert F. 1; Affiliation: 1: Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, Bldg 22, Rm 4176, 10903 New Hampshire Ave, Silver Spring, MD 20993-0002, USA; Source Info: Apr2007, Vol. 46 Issue 4, p229; Subject Term: ENDOTHELIUM; Subject Term: CELLULAR pathology; Subject Term: ULTRASTRUCTURE (Biology); Subject Term: HEMODYNAMICS; Subject Term: CELL-mediated cytotoxicity; Subject Term: WOUNDS & injuries; Subject Term: DRUGS -- Physiological effect; Subject Term: INFLAMMATION -- Mediators; Author-Supplied Keyword: Adhesion molecules; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Drugs; Author-Supplied Keyword: Endothelium; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Immune reactions; Author-Supplied Keyword: Vasculitis; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vph.2006.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=23808045&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-06924-002
AN - 2007-06924-002
AU - Spaulding, Anne C.
AU - Arriola, Kimberly R. Jacob
AU - Ramos, Kevin L.
AU - Hammett, Theodore
AU - Kennedy, Sofia
AU - Norton, Giulia
AU - Tinsley, Melinda
T1 - Enhancing linkages to HIV primary care in jail settings: Report on a consultants' meeting.
JF - Journal of Correctional Health Care
JO - Journal of Correctional Health Care
JA - J Correct Health Care
Y1 - 2007/04//
VL - 13
IS - 2
SP - 93
EP - 128
CY - US
PB - Sage Publications
SN - 1078-3458
SN - 1940-5200
AD - Spaulding, Anne C., Rollins School of Public Health, Emory University, 1518 Clifton Rd., NE, 472, Atlanta, GA, US, 30322
N1 - Accession Number: 2007-06924-002. Partial author list: First Author & Affiliation: Spaulding, Anne C.; Rollins School of Public Health, Emory University, Atlanta, GA, US. Release Date: 20070730. Correction Date: 20111107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: HIV Testing; Prisons. Minor Descriptor: Incarceration; Public Health. Classification: Criminal Rehabilitation & Penology (3386); Immunological Disorders (3291). Population: Human (10). References Available: Y. Page Count: 36. Issue Publication Date: Apr, 2007.
AB - More than 750,000 individuals are held in the nation's jails each day, but over 9 million pass through jails each year. The high turnover presents both opportunities and challenges in providing HIV testing in jails and linking HIV-infected inmates to services during incarceration and after release. Helping high-risk individuals in jails learn their HIV status and linking them to care is an important public health opportunity. The Health Resources and Services Administration is sponsoring a Special Projects of National Significance initiative to enhance linkages to primary care in jail settings through local demonstration projects. The Rollins School of Public Health and Abt Associates serve as the evaluation and support center for the initiative. A consultancy meeting was convened to review program models and strategies for HIV testing and linkages to HIV care in jails and in the community. This report highlights the critical issues that must be considered in implementing the demonstrations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV primary care
KW - jail settings
KW - consultants meeting
KW - HIV testing
KW - incarceration
KW - public health
KW - 2007
KW - HIV Testing
KW - Prisons
KW - Incarceration
KW - Public Health
KW - 2007
DO - 10.1177/1078345807301347
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06924-002&site=ehost-live&scope=site
UR - aspauld@sph.emory.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-04240-007
AN - 2007-04240-007
AU - Welbourne, Jennifer L.
AU - Eggerth, Donald
AU - Hartley, Tara A.
AU - Andrew, Michael E.
AU - Sanchez, Francisco
T1 - Coping strategies in the workplace: Relationships with attributional style and job satisfaction.
JF - Journal of Vocational Behavior
JO - Journal of Vocational Behavior
JA - J Vocat Behav
Y1 - 2007/04//
VL - 70
IS - 2
SP - 312
EP - 325
CY - Netherlands
PB - Elsevier Science
SN - 0001-8791
AD - Welbourne, Jennifer L., Department of Psychology, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC, US, 28223-0001
N1 - Accession Number: 2007-04240-007. Partial author list: First Author & Affiliation: Welbourne, Jennifer L.; Department of Psychology, University of North Carolina at Charlotte, Charlotte, NC, US. Release Date: 20070430. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Attribution; Coping Behavior; Job Satisfaction. Minor Descriptor: Nurses; Occupational Adjustment; Occupational Stress. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Occupational Attributional Style Questionnaire; Brief COPE; Minnesota Satisfaction Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Apr, 2007.
AB - This paper examined the relationships between workplace coping strategies, occupational attributional style, and job satisfaction among a sample of 190 nurses employed with a Veterans Affairs Medical Center. As an occupational group, nurses experience high levels of chronic workplace stressors. Participants completed a questionnaire packet containing the Brief COPE, the Minnesota Satisfaction Questionnaire (MSQ)-Short Form, and the Occupational Attributional Styles Questionnaire (OASQ). Results indicated that a positive occupational attributional style was associated with greater use of problem solving/cognitive restructuring coping styles and less use of avoidance coping styles to deal with workplace stress. This pattern of coping strategies was also associated with greater job satisfaction. Further analyses indicated that the relationship between occupational attributional style and job satisfaction was mediated by the use of problem solving/cognitive restructuring, and avoidance coping strategies to deal with workplace stress. Implications for workplace interventions and work adjustment counseling are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace coping strategies
KW - workplace stress
KW - occupational attributional style
KW - job satisfaction
KW - nurses
KW - work adjustment
KW - 2007
KW - Attribution
KW - Coping Behavior
KW - Job Satisfaction
KW - Nurses
KW - Occupational Adjustment
KW - Occupational Stress
KW - 2007
DO - 10.1016/j.jvb.2006.10.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-04240-007&site=ehost-live&scope=site
UR - jlwelbou@email.uncc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06408-009
AN - 2007-06408-009
AU - Foley, Daniel J.
AU - Vitiello, Michael V.
AU - Bliwise, Donald L.
AU - Ancoli-Israel, Sonia
AU - Monjan, Andrew A.
AU - Walsh, James K.
T1 - Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: Findings from the National Sleep Foundation '2003 Sleep in America' Poll.
JF - The American Journal of Geriatric Psychiatry
JO - The American Journal of Geriatric Psychiatry
JA - Am J Geriatr Psychiatry
Y1 - 2007/04//
VL - 15
IS - 4
SP - 344
EP - 350
CY - US
PB - Lippincott Williams & Wilkins
SN - 1064-7481
SN - 1545-7214
AD - Foley, Daniel J., Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, 1 Choke Cherry Rd., Rockville, MD, US, 20857
N1 - Accession Number: 2007-06408-009. PMID: 17384317 Partial author list: First Author & Affiliation: Foley, Daniel J.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Elsevier Science. Release Date: 20070514. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Major Depression; Napping; Pain; Sleepiness. Minor Descriptor: Urination. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2007.
AB - Objective: The objective of this study was to describe the prevalence and correlates of regular napping among older adults. Methods: The National Sleep Foundation's '2003 Sleep in America Poll,' a 20-minute telephone interview that focused on the topic of 'sleep and aging' (N = 1,506 adults 55-84 years of age). Results: Overall, 15% of respondents reported regular napping, ranging in prevalence from 10% among those 55-64 years of age to 25% among those 75-84 years of age. In addition to older age and a strong association with excessive daytime sleepiness, other factors that independently increased prevalence included a diagnosis of depression, bodily pain, and nocturia. Conclusions: Regular napping is common among older adults. Longitudinal studies of napping behavior and health status are needed to establish risk factors other than excessive daytime sleepiness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - aging
KW - excessive napping
KW - daytime sleepiness
KW - depression
KW - comorbidity
KW - nocturia
KW - pain
KW - 2007
KW - Aging
KW - Major Depression
KW - Napping
KW - Pain
KW - Sleepiness
KW - Urination
KW - 2007
DO - 10.1097/01.JGP.0000249385.50101.67
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06408-009&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9776-0473
UR -
UR - daniel.foley@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08465-007
AN - 2007-08465-007
AU - Kodell, Ralph L.
AU - Chen, James J.
T1 - On the use of hierarchical probabilistic models for characterizing and managing uncertainty in risk/safety assessment.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2007/04//
VL - 27
IS - 2
SP - 433
EP - 437
CY - United Kingdom
PB - Blackwell Publishing
SN - 0272-4332
SN - 1539-6924
AD - Kodell, Ralph L., Department of Biostatistics, UAMS, 4301 W. Markham St., #781, Little Rock, AR, US, 72205-7199
N1 - Accession Number: 2007-08465-007. PMID: 17511709 Partial author list: First Author & Affiliation: Kodell, Ralph L.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071112. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Neoplasms; Safety; Statistical Probability; Uncertainty; Risk Assessment. Classification: Statistics & Mathematics (2240); Cancer (3293). Population: Human (10). Methodology: Mathematical Model. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2007.
AB - A general probabilistically-based approach is proposed for both cancer and noncancer risk/safety assessments. The familiar framework of the original ADI/RfD formulation is used, substituting in the numerator a benchmark dose derived from a hierarchical pharmacokinetic/pharmacodynamic model and in the denominator a unitary uncertainty factor derived from a hierarchical animal/average human/sensitive human model. The empirical probability distributions of the numerator and denominator can be combined to produce an empirical human-equivalent distribution for an animal-derived benchmark dose in external-exposure units. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hierarchical probabilistic models
KW - uncertainty
KW - risk assessment
KW - safety
KW - cancer
KW - Bayesian probability
KW - Monte Carlo
KW - unitary factor
KW - 2007
KW - Neoplasms
KW - Safety
KW - Statistical Probability
KW - Uncertainty
KW - Risk Assessment
KW - 2007
DO - 10.1111/j.1539-6924.2007.00895.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08465-007&site=ehost-live&scope=site
UR - rlkodell@uams.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06315-002
AN - 2007-06315-002
AU - Smith, Derek R.
AU - Leggat, Peter A.
T1 - Tobacco smoking by occupation in Australia: Results from the 2004 to 2005 National Health Survey.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2007/04//
VL - 49
IS - 4
SP - 437
EP - 445
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - Smith, Derek R., International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2007-06315-002. PMID: 17426527 Partial author list: First Author & Affiliation: Smith, Derek R.; International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan. Release Date: 20070917. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Annual Conference of the Japan Society for Occupational Health, 80th, Apr, 2007, Osaka, Japan. Conference Note: Parts of this research were presented at the aforementioned conference. Major Descriptor: Blue Collar Workers; Epidemiology; Occupations; Tobacco Smoking. Classification: Personnel Attitudes & Job Satisfaction (3650); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Apr, 2007.
AB - Objective: This study presents the most recent estimates of Australia's national tobacco smoking rates by occupation. Methods: Smoking data was extracted from the 2004 to 2005 National Health Survey, which captured approximately 26,000 persons and achieved a response rate of around 90%. Participants were limited to those of working age (18 to 64 years), with data stratified by job category and gender during the analysis. Results: The prevalence of smoking among Australian workers is estimated to be 25% (28% among males and 21% among females). Tobacco usage is considerably less common among those who are employed compared with the unemployed. By job category, smoking was most common among laborers and the least common among professionals, managers, or administrators. Conclusions: Overall, this study suggests that Australian rates of tobacco smoking vary widely depending on occupation. Effective tobacco-control strategies targeting vulnerable sections of the workforce, particularly blue-collar workers, are clearly needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - rates of tobacco smoking
KW - occupation
KW - blue collar workers
KW - Australia
KW - 2007
KW - Blue Collar Workers
KW - Epidemiology
KW - Occupations
KW - Tobacco Smoking
KW - 2007
DO - 10.1097/JOM.0b013e3180430134
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06315-002&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-8202-2523
UR - smith@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-04470-021
AN - 2007-04470-021
AU - Grucza, Richard A.
AU - Abbacchi, Anna M.
AU - Przybeck, Thomas R.
AU - Gfroerer, Joseph C.
T1 - Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2007/04//
VL - 102
IS - 4
SP - 623
EP - 629
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Grucza, Richard A., Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO, US, 63110
N1 - Accession Number: 2007-04470-021. PMID: 17309538 Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Grucza, Richard A.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070430. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Grucza, Richard A. Major Descriptor: Drug Abuse; Epidemiology; Statistical Correlation; Surveys. Minor Descriptor: Substance Use Disorder. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2007.
AB - Aim: To assess the degree to which methodological differences might influence estimates of prevalence and correlates of substance use and disorders by comparing results from two recent surveys administered to nationally representative US samples. Methods: Post-hoc comparison of data from the 2002 National Survey on Drug Use and Health (NSDUH) with data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) administered in 2001-02. Results: Prevalence estimates for all substance use outcomes were higher in the NSDUH than in the NESARC; ratios of NSDUH to NESARC prevalences ranged from 2.1 to 5.7 for illegal drug use outcomes. In the NSDUH, past-year substance use disorder (SUD) prevalence estimates were higher for cocaine and heroin, but were similar to NESARC estimates for alcohol, marijuana and hallucinogens. However, prevalence estimates for past-year SUD conditional on past-year use were substantially lower in the NSDUH for marijuana, hallucinogens and cocaine. Associations among drug and SUD outcomes were substantially higher in the NESARC. Total SUD prevalence did not differ between surveys, but estimates for blacks and Hispanics were higher in the NSDUH. Conclusion: A number of methodological variables might have contributed to such discrepancies; among plausible candidates are factors related to privacy and anonymity, which may have resulted in higher use estimates in the NSDUH, and differences in SUD diagnostic instrumentation, which may have resulted in higher SUD prevalence among past-year substance users in the NESARC. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - discrepancies
KW - substance use correlates
KW - substance use disorders
KW - national surveys
KW - comparison data
KW - cocaine
KW - heroin
KW - alcohol
KW - marijuana
KW - hallucinogens
KW - 2007
KW - Drug Abuse
KW - Epidemiology
KW - Statistical Correlation
KW - Surveys
KW - Substance Use Disorder
KW - 2007
U1 - Sponsor: National Institutes of Health. Grant: K01DA16618. Recipients: Grucza, Richard A.
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism. Other Details: NESARC. Recipients: No recipient indicated
U1 - Sponsor: US Bureau of the Census, US. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Other Details: NSDUH. Recipients: No recipient indicated
U1 - Sponsor: RTI International. Recipients: No recipient indicated
DO - 10.1111/j.1360-0443.2007.01745.x
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UR -
UR - ORCID: 0000-0002-8191-6875
UR - rick@tci.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Harris, Emily L.
AU - McLaren, Christine E.
AU - Reboussin, David M.
AU - Gordeuk, Victor R.
AU - Barton, James C.
AU - Acton, Ronald T.
AU - McLaren, Gordon D.
AU - Vogt, Thomas M.
AU - Snively, Beverly M.
AU - Leiendecker-Foster, Catherine
AU - Holup, Joan L.
AU - Passmore, Leah V.
AU - Echfeldt, John H.
AU - Lin, Edward
AU - Adams, Paul C.
T1 - Serum Ferritin and Transferrin Saturation in Asians and Pacific Islanders.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2007/04/09/
VL - 167
IS - 7
M3 - Article
SP - 722
EP - 726
SN - 00039926
AB - The article focuses on a study on the reasons why Asian and Pacific Islanders in the Hemochromatosis and Iron Overload Screening Study had the highest prevalence of elevated serum ferritin and transferin saturation levels. There may be a need to interpret higher TS and SF levels in persons of Asian or Pacific Island heritage compared to Whites.
KW - HEMOCHROMATOSIS
KW - HEMOSIDEROSIS
KW - INBORN errors of metabolism
KW - PIGMENTATION disorders
KW - FERRITIN
KW - IRON in the body
KW - TRANSFERRIN
N1 - Accession Number: 24689357; Harris, Emily L. 1,2 McLaren, Christine E. 3 Reboussin, David M. 4 Gordeuk, Victor R. 5 Barton, James C. 6,7 Acton, Ronald T. 7 McLaren, Gordon D. 3,8 Vogt, Thomas M. 1 Snively, Beverly M. 4 Leiendecker-Foster, Catherine 9 Holup, Joan L. 1 Passmore, Leah V. 4 Echfeldt, John H. 9 Lin, Edward 10 Adams, Paul C. 11; Affiliation: 1: Kaiser Permanente Center for Health Research, Portland, Ore/Honolulu, Hawaii 2: National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md. 3: University of California, Irvine 4: Wake Forest University School of Medicine, Winston-Salem, NC 5: Howard University, Washington, DC 6: Southern Iron Disorders Center, Birmingham, Ala 7: University of Alabama, Birmingham 8: Department of Veterans Affairs Long Beach Healthcare System, Long Beach, Calif 9: University of Minnesota and University of Minnesota Medical Center, Fairview, Minneapolis 10: Rouge Valley Health System, Centenary Health Center, Toronto, Ontario 11: London Health Sciences Centre, London, Ontario; Source Info: 4/9/2007, Vol. 167 Issue 7, p722; Subject Term: HEMOCHROMATOSIS; Subject Term: HEMOSIDEROSIS; Subject Term: INBORN errors of metabolism; Subject Term: PIGMENTATION disorders; Subject Term: FERRITIN; Subject Term: IRON in the body; Subject Term: TRANSFERRIN; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gupta, Shalini
AU - Indelicato, Stephen R.
AU - Jethwa, Vijay
AU - Kawabata, Thomas
AU - Kelley, Marian
AU - Mire-Sluis, Anthony R.
AU - Richards, Susan M.
AU - Rup, Bonita
AU - Shores, Elizabeth
AU - Swanson, Steven J.
AU - Wakshull, Eric
T1 - Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2007/04/10/
VL - 321
IS - 1/2
M3 - Article
SP - 1
EP - 18
SN - 00221759
AB - Abstract: The administration of biological therapeutics can evoke some level of immune response to the drug product in the receiving subjects. An immune response comprised of neutralizing antibodies can lead to loss of efficacy or potentially more serious clinical sequelae. Therefore, it is important to monitor the immunogenicity of biological therapeutics throughout the drug product development cycle. Immunoassays are typically used to screen for the presence and development of anti-drug product antibodies. However, in-vitro cell-based assays prove extremely useful for the characterization of immunoassay-positive samples to determine if the detected antibodies have neutralizing properties. This document provides scientific recommendations based on the experience of the authors for the development of cell-based assays for the detection of neutralizing antibodies in non-clinical and clinical studies. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE response
KW - IMMUNOGLOBULINS
KW - DISEASE complications
KW - BROMODEOXYURIDINE
KW - 5-dimethylthiazol-2-yl-2
KW - 5-diphenyltetrazolium bromide] ( MTT )
KW - bromodeoxyuridine ( BrdU )
KW - Cell-based assay
KW - chloramphenicol acetyl transferase ( CAT )
KW - coefficient of variance ( CV )
KW - electrochemiluminescence ( ECL )
KW - enzyme immunoassay ( EIA )
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - erythropoietin ( EPO )
KW - flow activated cell sorting ( FACS )
KW - Green Fluorescent Protein ( GFP )
KW - human serum albumin ( HSA )
KW - Immunogenicity assay
KW - immunoglobulin ( Ig )
KW - interleukin-1 ( IL-1 )
KW - kinase induced receptor activation ( KIRA )
KW - megakaryocyte growth and development factor ( MGDF )
KW - messenger ribonucleic acid ( mRNA )
KW - monoclonal antibody ( MAb )
KW - NAb assay
KW - neutralizing antibody ( NAb )
KW - Neutralizing antibody bioassay
KW - pure red cell aplasia ( PRCA )
KW - radioimmunoassay ( RIA )
KW - recombinant human EPO ( rHuEPO )
KW - scintillation proximity assay ( SPA )
KW - Serum-based bioassay
KW - tumor necrosis factor. ( TNF )
KW - [3-(4
KW - [3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide] ( MTT )
N1 - Accession Number: 24462815; Gupta, Shalini 1; Email Address: shalinig@amgen.com Indelicato, Stephen R. 2 Jethwa, Vijay 3 Kawabata, Thomas 4 Kelley, Marian 5 Mire-Sluis, Anthony R. 6 Richards, Susan M. 7 Rup, Bonita 8 Shores, Elizabeth 9 Swanson, Steven J. 1 Wakshull, Eric 10; Affiliation: 1: Clinical Immunology, Amgen Inc., Thousand Oaks, CA 91320, USA 2: PharmSci Quality-Quality Systems Improvement Office, Schering Plough Research Institute, Kenilworth, NJ, 07033, USA 3: Bioanalytical QC RTP, Biogen Idec, Research Triangle Park, NC 27709, USA 4: Safety Sciences, Pfizer Global Research and Development, Groton, CT 06340, USA 5: Clinical Pharmacology & Experimental Medicine, Centocor R&D Inc., Radnor, PA 19087, USA 6: Corporate Operations, Amgen Inc., Thousand Oaks, CA 91320, USA 7: Immunology, Cell & Protein Therapeutics R&D, Genzyme Corp. Framingham, MA 01701, USA 8: Bioanalytical R&D, Wyeth Research, Andover, MA 01810, USA 9: Division of Therapeutic Protein, Office of Biotechnology Product, Center for Drug Evaluation and Research, FDA, MD 20892, USA 10: Clinical Science & Technology, Biogen Idec, Cambridge, MA 02142, USA; Source Info: Apr2007, Vol. 321 Issue 1/2, p1; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULINS; Subject Term: DISEASE complications; Subject Term: BROMODEOXYURIDINE; Author-Supplied Keyword: 5-dimethylthiazol-2-yl-2; Author-Supplied Keyword: 5-diphenyltetrazolium bromide] ( MTT ); Author-Supplied Keyword: bromodeoxyuridine ( BrdU ); Author-Supplied Keyword: Cell-based assay; Author-Supplied Keyword: chloramphenicol acetyl transferase ( CAT ); Author-Supplied Keyword: coefficient of variance ( CV ); Author-Supplied Keyword: electrochemiluminescence ( ECL ); Author-Supplied Keyword: enzyme immunoassay ( EIA ); Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: erythropoietin ( EPO ); Author-Supplied Keyword: flow activated cell sorting ( FACS ); Author-Supplied Keyword: Green Fluorescent Protein ( GFP ); Author-Supplied Keyword: human serum albumin ( HSA ); Author-Supplied Keyword: Immunogenicity assay; Author-Supplied Keyword: immunoglobulin ( Ig ); Author-Supplied Keyword: interleukin-1 ( IL-1 ); Author-Supplied Keyword: kinase induced receptor activation ( KIRA ); Author-Supplied Keyword: megakaryocyte growth and development factor ( MGDF ); Author-Supplied Keyword: messenger ribonucleic acid ( mRNA ); Author-Supplied Keyword: monoclonal antibody ( MAb ); Author-Supplied Keyword: NAb assay; Author-Supplied Keyword: neutralizing antibody ( NAb ); Author-Supplied Keyword: Neutralizing antibody bioassay; Author-Supplied Keyword: pure red cell aplasia ( PRCA ); Author-Supplied Keyword: radioimmunoassay ( RIA ); Author-Supplied Keyword: recombinant human EPO ( rHuEPO ); Author-Supplied Keyword: scintillation proximity assay ( SPA ); Author-Supplied Keyword: Serum-based bioassay; Author-Supplied Keyword: tumor necrosis factor. ( TNF ); Author-Supplied Keyword: [3-(4; Author-Supplied Keyword: [3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide] ( MTT ); Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.jim.2006.12.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106110463
T1 - Complexities of the herbal nomenclature system in traditional Chinese medicine (TCM): lessons learned from the misuse of Aristolochia-related species and the importance of the pharmaceutical name during botanical drug product development.
AU - Wu KM
AU - Farrelly JG
AU - Upton R
AU - Chen J
Y1 - 2007/04/10/
N1 - Accession Number: 106110463. Language: English. Entry Date: 20070629. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Alternative/Complementary Therapies; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9438794.
KW - Plants, Medicinal
KW - Dietary Supplements
KW - Medicine, Chinese Traditional
KW - Nomenclature
KW - Plants, Medicinal -- Classification
KW - Human
SP - 273
EP - 279
JO - Phytomedicine
JF - Phytomedicine
JA - PHYTOMEDICINE
VL - 14
IS - 4
CY - London,
PB - Elsevier GmbH, Urban & Fischer Verlag
AB - Herbs used in traditional Chinese medicine (TCM) have diverse cultural/historical backgrounds and are described based on complex nomenclature systems. Using the family Aristolochiaceae as an example, at least three categories of nomenclature could be identified: (1) one-to-one (one plant part from one species): the herb guan mutong refers to the root of Aristolochia manshuriensis; (2) multiple-to-one (multiple plant parts from the same species serve as different herbs): three herbs, madouling, qingmuxiang and tianxianteng, derived respectively from the fruit, root and stem of Aristolochia debilis; and (3) one-to-multiple (one herb refers to multiple species): the herb fangji refers to the root of either Aristolochia fangchi, Stephania tetrandra or Cocculus trilobus; in this case, the first belongs to a different family (Aristolochiaceae) than the latter two (Menispermaceae), and only the first contains aristolochic acid (AA), as demonstrated by independent analytical data provided in this article. Further, mutong (Akebia quinata) is allowed in TCM herbal medicine practice to be substituted with either guan mutong (Aristolochia manshuriensis) or chuan mutong (Clematis armandii); and mu fangji (Cocculus trilobus) by guang fanchi (Aristolochia fangchi) or hanzhong fangji (Aristolochia heterophylla), thereby increasing the risk of exposing renotoxic AA-containing Aristolochia species to patients. To avoid these and other confusions, we wish to emphasize the importance of a pharmaceutical name, which defines the species name, the plant part, and sometimes the special process performed on the herb, including cultivating conditions. The pharmaceutical name as referred to in this article is defined, and is limited to those botanicals that are intended to be used as drug. It is hoped that by following the pharmaceutical name, toxic herbs can be effectively identified and substitution or adulteration avoided.
SN - 0944-7113
AD - Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
U2 - PMID: 16863692.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Trainor, Nicole B.
AU - Crill, Wayne D.
AU - Roberson, Jill A.
AU - Chang, Gwong-Jen J.
T1 - Mutation analysis of the fusion domain region of St. Louis encephalitis virus envelope protein
JO - Virology
JF - Virology
Y1 - 2007/04/10/
VL - 360
IS - 2
M3 - Article
SP - 398
EP - 406
SN - 00426822
AB - Abstract: The immune response to flavivirus infections produces both species-specific and flavivirus cross-reactive antibodies. The presence of cross-reactive antibodies complicates serodiagnosis of flavivirus infections, especially secondary infections caused by a heterologous virus. A successful public health response to the growing global threat posed by flaviviruses necessitates the development of virus-specific diagnostic antigens. The flavivirus envelope (E) glycoprotein is the principle antigen stimulating protective immunity during infection. Using recombinant St. Louis encephalitis virus-like particles (VLPs), we have identified amino acid residues involved in flavivirus cross-reactive epitope determinants. Most significant among the residues studied are three highly conserved amino acids in the fusion peptide: Gly104, Gly106, and Leu107. Substitutions of these residues dramatically influenced VLP secretion and cross-reactive monoclonal antibody reactivity. These results provide critical insight into the antigenic structure of the flaviviral E protein and toward development of species-specific diagnostic antigens that should improve both flavivirus diagnosis and estimates of disease burden. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRAIN diseases
KW - IMMUNOGLOBULINS
KW - MUTATION (Biology)
KW - ANTIGENIC determinants
KW - Cross-reactive epitopes
KW - Flavivirus
KW - Fusion peptide
KW - St. Louis encephalitis virus
KW - West Nile virus
N1 - Accession Number: 24541033; Trainor, Nicole B. 1 Crill, Wayne D.; Email Address: wcrill@cdc.gov Roberson, Jill A. 1 Chang, Gwong-Jen J. 1; Affiliation: 1: Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA; Source Info: Apr2007, Vol. 360 Issue 2, p398; Subject Term: BRAIN diseases; Subject Term: IMMUNOGLOBULINS; Subject Term: MUTATION (Biology); Subject Term: ANTIGENIC determinants; Author-Supplied Keyword: Cross-reactive epitopes; Author-Supplied Keyword: Flavivirus; Author-Supplied Keyword: Fusion peptide; Author-Supplied Keyword: St. Louis encephalitis virus; Author-Supplied Keyword: West Nile virus; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2006.10.033
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Zigui
AU - Schiffman, Mark
AU - Herrero, Rolando
AU - DeSalle, Rob
AU - Burk, Robert D.
T1 - Human papillomavirus (HPV) types 101 and 103 isolated from cervicovaginal cells lack an E6 open reading frame (ORF) and are related to gamma-papillomaviruses
JO - Virology
JF - Virology
Y1 - 2007/04/10/
VL - 360
IS - 2
M3 - Article
SP - 447
EP - 453
SN - 00426822
AB - Abstract: Complete genomes of HPV101 and HPV103 were PCR amplified and cloned from cervicovaginal cells of a 34-year-old female with cervical intraepithelial neoplasia grade 3 (CIN 3) and a 30-year-old female with a normal Pap test, respectively. HPV101 and HPV103 contain 4 early genes (E7, E1, E2, and E4) and 2 late genes (L2 and L1), but both lack the canonical E6 ORF. Pairwise alignment similarity of the L1 ORF nucleotide sequences of HPV101 and HPV103 indicated that they are at least 30% dissimilar to each other and all known PVs. However, similarities of the other ORFs (E7, E1, E2, and L2) indicated that HPV101 and HPV103 are most related to each other. Phylogenetic analyses revealed that these two types form a monophyletic clade, clustering together with the gamma- and pi-PV groups. These data demonstrated that HPV genomes closely related to papillomaviruses identified from cutaneous epithelia can be isolated from the genital mucosal region. Moreover, this is the first report of HPVs lacking an E6 ORF and phylogenetic evidence suggests this occurred subsequent to their emergence from the gamma-/pi-PVs. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAPILLOMAVIRUSES
KW - GENOMES
KW - EVOLUTION (Biology)
KW - GENOMICS
KW - Complete genome
KW - Human papillomavirus
KW - Molecular clock
KW - Novel type
KW - Phylogeny
N1 - Accession Number: 24541037; Chen, Zigui 1 Schiffman, Mark 2 Herrero, Rolando 3 DeSalle, Rob 4 Burk, Robert D. 1,5; Email Address: burk@aecom.yu.edu; Affiliation: 1: Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine of Yeshiva University, NY 10461, USA 2: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA 3: Proyecto Epidemiológico Guanacaste, Costa Rican Foundation for Health Sciences, San José, Costa Rica 4: Division of Invertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA 5: Department of Pediatrics, Epidemiology and Population Health and Obstetrics, Gynecology and Woman’s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine of Yeshiva University, NY 10461, USA; Source Info: Apr2007, Vol. 360 Issue 2, p447; Subject Term: PAPILLOMAVIRUSES; Subject Term: GENOMES; Subject Term: EVOLUTION (Biology); Subject Term: GENOMICS; Author-Supplied Keyword: Complete genome; Author-Supplied Keyword: Human papillomavirus; Author-Supplied Keyword: Molecular clock; Author-Supplied Keyword: Novel type; Author-Supplied Keyword: Phylogeny; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.virol.2006.10.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jungkweon Choi
AU - Jin Chul Kim
AU - Yong Bok Lee
AU - In Seon Kim
AU - Yong Ki Park
AU - Nam Hwi Hur
T1 - Fabrication of silica-coated magnetic nanoparticles with highly photoluminescent lanthanide probes.
JO - Chemical Communications
JF - Chemical Communications
Y1 - 2007/04/11/
VL - 2007
IS - 16
M3 - Article
SP - 1644
EP - 1646
SN - 13597345
AB - Bi-functional nanoparticles (NPs) that consist of silica-coated magnetic cores and luminescent lanthanide (Ln) ions anchored on the silica surface via organic linker molecules are reported. Compared to individual Ln ions, the hybrid NPs show a drastically enhanced photoluminescence due to the efficient ligand-to-metal energy transfer in the Ln-loaded NPs: the new bi-functional NPs could be used in a variety of biological applications involving magnetic separation and optical detection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Communications is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - SILICON compounds
KW - LUMINESCENCE
KW - MAGNETIC separation
N1 - Accession Number: 25209067; Jungkweon Choi 1 Jin Chul Kim 2 Yong Bok Lee 3 In Seon Kim 1 Yong Ki Park 1 Nam Hwi Hur 4; Affiliation: 1: Div. of Metrology for Quality Life, Korea Research Institute of Standards and ScienceYuseong P. O. Box 102 Daejeon Korea 2: Korea Center for Food and Drug Inspection Hazard Analysis Team, Gyeongin Regional Food and Drug Administration Incheon Korea 3: Div. of Electron Microscopic Research, Korea Basic Science InstituteYuseong P. O. Box 41 Daejeon Korea 4: Department of Chemistry, Sogang University Seoul Korea; Source Info: Apr2007, Vol. 2007 Issue 16, p1644; Subject Term: NANOPARTICLES; Subject Term: SILICON compounds; Subject Term: LUMINESCENCE; Subject Term: MAGNETIC separation; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - Woodruff, Jeffrey T.
AU - d’Avignon, D. André
T1 - Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/04/11/
VL - 43
IS - 5
M3 - Article
SP - 1615
EP - 1621
SN - 07317085
AB - Abstract: A new analogue of sildenafil was detected in an herbal dietary supplement, which was sold over the internet and promoted as a product for the enhancement of sexual performance. The structure of the compound was established using LC–MS, UV spectroscopy, MS–MS, and NMR. In addition, the compound was cleaved at its sulfonamide S–N bond yielding a sulfonic acid and an amine, which were independently characterized using LC–MS, GC–MS, and derivatization. The compound, named methisosildenafil, is a novel synthetic analogue of sildenafil in which the N-methylpiperazine moiety has been replaced with 2,6-dimethylpiperazine. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - SILDENAFIL
KW - LIQUID chromatography
KW - MASS spectrometry
KW - Dietary supplements
KW - Liquid chromatography–mass spectrometry (LC–MS)
KW - Methisosildenafil
KW - Nuclear magnetic resonance (NMR)
KW - Sildenafil analogue
N1 - Accession Number: 24460192; Reepmeyer, John C. 1; Email Address: john.reepmeyer@fda.hhs.gov Woodruff, Jeffrey T. 1 d’Avignon, D. André 2; Affiliation: 1: US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA 2: Department of Chemistry, Washington University, St. Louis, MO 63130, USA; Source Info: Apr2007, Vol. 43 Issue 5, p1615; Subject Term: DIETARY supplements; Subject Term: SILDENAFIL; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Liquid chromatography–mass spectrometry (LC–MS); Author-Supplied Keyword: Methisosildenafil; Author-Supplied Keyword: Nuclear magnetic resonance (NMR); Author-Supplied Keyword: Sildenafil analogue; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2006.11.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24460192&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ciavarella, Anthony B.
AU - Gupta, Abhay
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
AU - Faustino, Patrick J.
T1 - Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/04/11/
VL - 43
IS - 5
M3 - Article
SP - 1647
EP - 1653
SN - 07317085
AB - Abstract: A simple isocratic reversed-phase HPLC method for the determination of gabapentin and its major degradation impurity, 3,3-pentamethylene-4-butyrolactam, was developed and validated for use in the analysis of pharmaceutical tablets and capsules. Separation was achieved on a Brownlee Spheri-5 Cyano column using an acetonitrile–10mM KH2PO4/10mM K2HPO4 (pH 6.2) (8:92, v/v) mobile phase. The compounds were eluted isocratically at a flow rate of 1mL/min. Both compounds were analyzed with UV detection at 210nm. The method was validated according to USP Category I requirements for gabapentin and USP Category II for 3,3-pentamethylene-4-butyrolactam. The validation characteristics included accuracy, precision, linearity, range, specificity, limit of quantitation and robustness. Validation acceptance criteria were met in all cases. This method was used successfully for the quality assessment of four gabapentin drug products. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LACTAMS
KW - TABLETS (Medicine)
KW - CAPSULES (Pharmacy)
KW - ACETONITRILE
KW - Degradation
KW - Drug products
KW - Gabapentin
KW - HPLC
KW - Impurity
KW - Lactam
N1 - Accession Number: 24460203; Ciavarella, Anthony B. 1 Gupta, Abhay 1 Sayeed, Vilayat A. 2 Khan, Mansoor A. 1 Faustino, Patrick J. 1; Email Address: patrick.faustino@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, Life Science Building 64, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Office of Generic Drugs, Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Apr2007, Vol. 43 Issue 5, p1647; Subject Term: LACTAMS; Subject Term: TABLETS (Medicine); Subject Term: CAPSULES (Pharmacy); Subject Term: ACETONITRILE; Author-Supplied Keyword: Degradation; Author-Supplied Keyword: Drug products; Author-Supplied Keyword: Gabapentin; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Impurity; Author-Supplied Keyword: Lactam; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2006.12.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24460203&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiao, Yang
AU - Su, Mingming
AU - Chen, Minjun
AU - Jia, Wei
AU - Chou, Yiqun
AU - Huang, Zhongyi
AU - Yang, Nanlin
AU - Tong, Weida
T1 - LC/ESI-MS method for the determination of trimetazidine in human plasma: Application to a bioequivalence study on Chinese volunteers
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/04/11/
VL - 43
IS - 5
M3 - Article
SP - 1804
EP - 1807
SN - 07317085
AB - Abstract: A rapid liquid chromatography electrospray ionization mass spectrometry (LC/ESI-MS) method with good sensitivity and specificity has been developed and validated for the identification and quantification of trimetazidine in human plasma. Trimetazidine and lidocaine (internal standard) were isolated from plasma samples by protein precipitation with methanol. The chromatographic separation was accomplished on a Xterra MS C18 Column (150mm×4.6mm, 5μm particle size) with the mobile phase consisting of methanol and water (40:60, v/v) (pH 2.0, adjusted with trifluoroacetic acid), and the flow rate was set at 0.6mL/min. Detection was performed on a single quadruple mass spectrometer by selected ion monitoring (SIM) mode (m/z 267.0 for trimetazidine and m/z 235.0 for lidocaine) with the retention time at about 3.47 and 5.05min, respectively. The calibration curve for trimetazidine was satisfactory with regression coefficient 0.9995 over the range of 2.5–100ng/mL in the plasma. The LOQ (S/N=10) was accordingly 2.5ng/mL. The intra-day and inter-day precision expressed as relative standard deviation was 2.83–6.10% and 4.83–5.82%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference product) in 19 healthy male Chinese volunteers. After a single 20mg dose for the test and reference product, the resulting mean of major pharmacokinetic parameters such as AUC0–24, AUC0−∞ , C max, T max and t 1/2 of trimetazidine were (673.1±117.6nghmL−1 versus 652.3±121.9nghmL−1), (717.1±120.9nghmL−1 versus 692±128.6nghmL−1), (74.85±12.13ngmL−1 versus 71.93±14.32ngmL−1), (2.312±0.663h versus 2.211±0.608h) and (4.785±0.919h versus 4.740±0.823h), respectively, indicating that these two kinds of tablets were bioequivalent in the Chinese population. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - DRUGS -- Therapeutic equivalency
KW - PHARMACOKINETICS
KW - MASS spectrometry
KW - Bioequivalence
KW - Chinese population
KW - LC/ESI-MS
KW - Pharmacokinetics
KW - Trimetazidine
N1 - Accession Number: 24460262; Jiao, Yang 1 Su, Mingming 1 Chen, Minjun 1; Email Address: minjunchen@gmail.com Jia, Wei 1 Chou, Yiqun 2 Huang, Zhongyi 2 Yang, Nanlin 3 Tong, Weida 4; Affiliation: 1: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, China 2: Shanghai Jing An Central Hospital, Shanghai 200040, China 3: JiangSu WuZhong Chinese Traditional Medicine R&D Co., Ltd., Suzhou 215000, China 4: Division of Systems Toxicology, National Center for Toxicological Research (NCTR), FDA, 3900 NCTR Road, Jefferson, AR 72079, United States; Source Info: Apr2007, Vol. 43 Issue 5, p1804; Subject Term: BLOOD plasma; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: PHARMACOKINETICS; Subject Term: MASS spectrometry; Author-Supplied Keyword: Bioequivalence; Author-Supplied Keyword: Chinese population; Author-Supplied Keyword: LC/ESI-MS; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Trimetazidine; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jpba.2006.11.040
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24460262&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Asafu-Adjaye, Ebenezer B.
AU - Faustino, Patrick J.
AU - Tawakkul, Mobin A.
AU - Anderson, Lawrence W.
AU - Yu, Lawrence X.
AU - Kwon, Hyojong
AU - Volpe, Donna A.
T1 - Validation and application of a stability-indicating HPLC method for the in vitro determination of gastric and intestinal stability of venlafaxine
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/04/11/
VL - 43
IS - 5
M3 - Article
SP - 1854
EP - 1859
SN - 07317085
AB - Abstract: Gastrointestinal stability of venlafaxine was evaluated in vitro in simulated gastric (SGF) and intestinal (SIF) fluids using a stability indicating HPLC method. The method was validated using a 5μm Ascentis® C18 column (150mm×4.6mm) and mobile phase consisting of 30% acetonitrile in 20mM potassium phosphate buffer (pH 6.5) delivered isocratically at a flow rate of 1mL/min with UV detection at 228nm. Venlafaxine in USP simulated gastric and intestinal fluids (0.4mg/mL) was incubated at 37°C in a shaking water bath. The gastric stability study samples were assayed at 0, 15, 30 and 60min intervals while sampling for the intestinal stability study was at 0, 1, 2 and 3h. System suitability determinations gave R.S.D.s of 0.68, 0.5 and 3.9% for retention factor (k′), peak area and tailing factor, respectively. The method was shown to be accurate, precise, specific, and linear over the analytical range. Intra- and inter-day precision was <5.3%. Forced degradation studies of drug substance in basic media at 70°C as well as in H2O2 for 1h and ultra-violet photostability studies at 255 and 365nm for 24h did not produce any detectable degradation products. Forced degradation studies of drug substance in acidic media at 70°C for 1h produced the dehydro-venlafaxine degradant. Venlafaxine was stable in SGF (pH ∼1.2) for the 1-h incubation period and in SIF (pH 6.8) up to 3h with <1.5% relative difference (RD) between the amount of drug added and that found for all time points. This stability experiment in simulated gastric and intestinal fluids suggests that drug loss in the gastrointestinal tract takes place by membrane permeation rather than a degradation process. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - VENLAFAXINE
KW - ANTIDEPRESSANTS
KW - ACETONITRILE
KW - Dehydro-venlafaxine
KW - Gastric
KW - In vitro
KW - Intestinal
KW - Stability
KW - Venlafaxine
N1 - Accession Number: 24460324; Asafu-Adjaye, Ebenezer B. 1 Faustino, Patrick J. 1; Email Address: patrick.faustino@fda.hhs.gov Tawakkul, Mobin A. 1 Anderson, Lawrence W. 2 Yu, Lawrence X. 3 Kwon, Hyojong 3 Volpe, Donna A. 1; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States 2: Laboratory of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States 3: Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20855, United States; Source Info: Apr2007, Vol. 43 Issue 5, p1854; Subject Term: HIGH performance liquid chromatography; Subject Term: VENLAFAXINE; Subject Term: ANTIDEPRESSANTS; Subject Term: ACETONITRILE; Author-Supplied Keyword: Dehydro-venlafaxine; Author-Supplied Keyword: Gastric; Author-Supplied Keyword: In vitro; Author-Supplied Keyword: Intestinal; Author-Supplied Keyword: Stability; Author-Supplied Keyword: Venlafaxine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2006.12.035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24460324&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fogg, Christiana N.
AU - Americo, Jeffrey L.
AU - Lustig, Shlomo
AU - Huggins, John W.
AU - Smith, Scott K.
AU - Damon, Inger
AU - Resch, Wolfgang
AU - Earl, Patricia L.
AU - Klinman, Dennis M.
AU - Moss, Bernard
T1 - Adjuvant-enhanced antibody responses to recombinant proteins correlates with protection of mice and monkeys to orthopoxvirus challenges
JO - Vaccine
JF - Vaccine
Y1 - 2007/04/12/
VL - 25
IS - 15
M3 - Article
SP - 2787
EP - 2799
SN - 0264410X
AB - Abstract: Recombinant proteins are being evaluated as smallpox and monkeypox vaccines because of their perceived safety compared to live vaccinia virus. Previously, we demonstrated that three or more injections of a Ribi-type adjuvant with a combination of three proteins from the outer membranes of intracellular (L1 protein) and extracellular (A33 and B5 proteins) forms of vaccinia virus protected mice against a lethal intranasal challenge with vaccinia virus. Here, we compared several adjuvants and found that QS-21 and to a lesser extent alum+CpG oligodeoxynucleotides accelerated and enhanced neutralizing antibody responses to a mixture of L1 and A33 proteins, provided the highest ratio of IgG2a to IgG1 isotype response, and protected mice against disease and death after only two immunizations 3 weeks apart. In addition, monkeys immunized with recombinant vaccinia virus proteins and QS-21 developed neutralizing antibody to monkeypox virus and had reduced virus load, skin lesions, and morbidity compared to the non-immunized group following monkeypox virus challenge. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aluminum sulfate
KW - Vaccination
KW - Recombinant proteins
KW - Monkeys as laboratory animals
KW - Monkeypox
KW - Smallpox
KW - Vaccinia virus
N1 - Accession Number: 24387177; Fogg, Christiana N. 1; Americo, Jeffrey L. 1; Lustig, Shlomo 1; Huggins, John W. 2; Smith, Scott K. 3; Damon, Inger 3; Resch, Wolfgang 1; Earl, Patricia L. 1; Klinman, Dennis M. 4; Moss, Bernard 1; Email Address: bmoss@nih.gov; Affiliations: 1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; 2: United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA; 3: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; 4: Division of Viral Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Issue Info: Apr2007, Vol. 25 Issue 15, p2787; Thesaurus Term: Aluminum sulfate; Thesaurus Term: Vaccination; Subject Term: Recombinant proteins; Subject Term: Monkeys as laboratory animals; Author-Supplied Keyword: Monkeypox; Author-Supplied Keyword: Smallpox; Author-Supplied Keyword: Vaccinia virus; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.vaccine.2006.12.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=24387177&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Agwunobi, John O.
T1 - Should the US and Russia destroy their stocks of smallpox virus?
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2007/04/14/
VL - 334
IS - 7597
M3 - Article
SP - 775
EP - 775
SN - 09598146
AB - The article presents the authors' opinions on whether the United States and Russia should destroy their stocks of the smallpox virus which are used to create smallpox vaccines.. Arguments are presented from Edward Hammond which suggest that keeping the viruses may prove to be dangerous for humanity due to the threat of its being used by terrorists. Arguments are presented from John O. Agwunobi which suggest that until new vaccines are discovered which do not need live smallpox samples to be developed, the stocks should not be destroyed.
KW - PREVENTIVE medicine
KW - SMALLPOX
KW - POXVIRUS diseases
KW - PREVENTION
KW - VACCINES -- Biotechnology
KW - VIRUSES -- Catalogs & collections
KW - UNITED States
KW - RUSSIA
N1 - Accession Number: 24922176; Agwunobi, John O. 1; Email Address: john.agwunobi@hhs.gov; Affiliation: 1: assistant secretary for health, US Department of Health and Human Services. 200 Independence Avenue, SW, Washington, DC 20201; Source Info: 4/14/2007, Vol. 334 Issue 7597, p775; Subject Term: PREVENTIVE medicine; Subject Term: SMALLPOX; Subject Term: POXVIRUS diseases; Subject Term: PREVENTION; Subject Term: VACCINES -- Biotechnology; Subject Term: VIRUSES -- Catalogs & collections; Subject Term: UNITED States; Subject Term: RUSSIA; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nilsa I. Loyo-Berríos
AU - Rafael Irizarry
AU - Joseph G. Hennessey
AU - Xuguang Grant Tao
AU - Genevieve Matanoski
T1 - Air Pollution Sources and Childhood Asthma Attacks in Cataño, Puerto Rico.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2007/04/15/
VL - 165
IS - 8
M3 - Article
SP - 927
EP - 935
SN - 00029262
AB - Asthma prevalence in the Cataño Air Basin of Puerto Rico is 27% for children aged 13–14 years and 45% for children aged 5–6 years. There is concern that these rates are related to air pollution. The authors conducted a nested case-control study to evaluate whether proximity to air pollution point sources was associated with increased risk of asthma attacks. For 1997–2001, 1,382 asthma-related medical visits (International Classification of Diseases, Ninth Revision, codes 493 and 493.9) in children under 17 were identified through health insurance claims. Controls were children with no asthma attacks who were randomly selected from enrollees in two health insurance companies by incidence density sampling (1:5) and matched to cases on gender, age, insurance company, and event date. The distance from a point source to the subject's residence area represented a surrogate exposure measurement. Odds ratios for a 1-km decrease in distance were obtained by conditional logistic regression. Risk of asthma attack was associated with residing near a grain mill (odds ratio (OR) = 1.35), petroleum refinery (OR = 1.44), asphalt plant (OR = 1.23), or power plant (OR = 1.28) (all p's < 0.05). Residence near major air emissions sources (>100 tons/year) increased asthma attack risk by 108% (p < 0.05). These results showed that proximity to some air pollution sources is associated with increased risks of asthma attacks. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASTHMA
KW - BRONCHIAL diseases
KW - LUNG diseases
KW - RESPIRATORY allergy
KW - ASTHMA in children
KW - AIR pollution
N1 - Accession Number: 24695431; Nilsa I. Loyo-Berríos 1 Rafael Irizarry 2 Joseph G. Hennessey 3 Xuguang Grant Tao 4 Genevieve Matanoski 5; Affiliation: 1: Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, US Department of Health and Human Services, Rockville, MD 2: Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 3: Center for Imaging Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 4: Division of Environmental and Occupational Health, School of Medicine, Johns Hopkins University, Baltimore, MD 5: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Source Info: Apr2007, Vol. 165 Issue 8, p927; Subject Term: ASTHMA; Subject Term: BRONCHIAL diseases; Subject Term: LUNG diseases; Subject Term: RESPIRATORY allergy; Subject Term: ASTHMA in children; Subject Term: AIR pollution; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Probst, Claudia
AU - Njapau, Henry
AU - Cotty, Peter J.
T1 - Outbreak of an Acute Aflatoxicosis in Kenya in 2004: Identification of the Causal Agent.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/04/15/
VL - 73
IS - 8
M3 - Article
SP - 2762
EP - 2764
SN - 00992240
AB - Maize contaminated with aflatoxins has been implicated in deadly epidemics in Kenya three times since 1981, but the fungi contaminating the maize with aflatoxins have not been characterized. Here we associate the S strain of Aspergillus flavus with lethal aflatoxicoses that took more than 125 lives in 2004. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORN
KW - FUNGI
KW - AFLATOXINS
KW - METABOLITES
KW - FOOD contamination
KW - DISEASES -- Causes & theories of causation
KW - FOOD poisoning
KW - EPIDEMICS
KW - KENYA
N1 - Accession Number: 25055229; Probst, Claudia 1 Njapau, Henry 2 Cotty, Peter J. 1,3; Email Address: pjcotty@email.arizona.edu; Affiliation: 1: Department of Plant Sciences, The University of Arizona, Tucson, Arizona 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 3: USDA -ARS, Department of Plant Sciences, The University of Arizona, Tucson, Arizona; Source Info: Apr2007, Vol. 73 Issue 8, p2762; Subject Term: CORN; Subject Term: FUNGI; Subject Term: AFLATOXINS; Subject Term: METABOLITES; Subject Term: FOOD contamination; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FOOD poisoning; Subject Term: EPIDEMICS; Subject Term: KENYA; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.02370-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25055229&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pfeiffer, Christine M.
AU - Johnson, Clifford L.
AU - Jain, Ram B.
AU - Yetley, Elizabeth A.
AU - Picciano, Mary Frances
AU - Rader, Jeanne I.
AU - Fisher, Ken D.
AU - Mulinare, Joe
AU - Osterloh, John D.
T1 - Trends in blood folate levels in the United States, 1988-2004.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/15/
VL - 21
IS - 5
M3 - Article
SP - A104
EP - A104
AB - Monitoring the folate status of the U.S. population through the National Health and Nutrition Examination Survey (NHANES) has been a public health priority for the last two decades, particularly so since folic acid fortification was introduced in 1998. We analyzed data on serum and red blood cell (RBC) folate levels from NHANES 1988-1994 and from each of three post-fortification survey periods (1999-2000, 2001-2002, and 2003-2004). Serum and RBC folate levels showed sharp increases (156% and 59%, respectively) in NHANES 1999-2000, then showed slight declines (16% and 8%, respectively) in two subsequent survey periods. Prevalence estimates of low serum and RBC folate levels declined by an order of magnitude from pre- to post-fortification (16% to 0.5% for serum folate and 31% to 3% for RBC folate) but remained generally unchanged thereafter. Whereas the entire distribution of blood folate levels shifted to higher levels from pre- to post-fortification, only the upper end of the distribution declined to slightly lower levels during the two most recent survey periods. The decrease in folate levels observed post fortification is small compared with the increase after the introduction of fortification and is not expected to have a negative impact on health outcomes related to suboptimal folate levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - ERYTHROCYTES
KW - SERUM
KW - HEALTH & Nutrition Examination Survey
KW - UNITED States
N1 - Accession Number: 25632010; Pfeiffer, Christine M. 1 Johnson, Clifford L. 2 Jain, Ram B. 1 Yetley, Elizabeth A. 3 Picciano, Mary Frances 3 Rader, Jeanne I. 4 Fisher, Ken D. 3 Mulinare, Joe 5 Osterloh, John D. 1; Affiliation: 1: Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA, 30341 2: Centers for Disease Control and Prevention, HYAT Bldg IV Rm 4205, Hyattsville, MD, 20782 3: National Institutes of Health, 6100 Executive Blvd, Rockville, MD, 20892 4: Food and Drug Administration, CPK1, 1E005, College Park, MD, 20740 5: Centers for Disease Control and Prevention, EXPK Bldg 12 Rm 4027, Atlanta, GA, 30329; Source Info: Apr2007, Vol. 21 Issue 5, pA104; Subject Term: FOLIC acid; Subject Term: ERYTHROCYTES; Subject Term: SERUM; Subject Term: HEALTH & Nutrition Examination Survey; Subject Term: UNITED States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Apopa, Patrick Leo
AU - Lin, Gary Xiong
AU - Xiaoqing He
AU - Qiang Ma
T1 - Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/15/
VL - 21
IS - 5
M3 - Article
SP - A287
EP - A287
AB - The antioxidant-activated transcription factor Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) controls the induction of cytoprotective and detoxification genes against toxic materials and oxidative injuries. The signaling events leading to the activation of Nrf2 has not been clear; in particular, the role of phosphorylation in Nrl2 function remains controversial. We report that phenolic compounds, like antioxidant tertbutylhydroquinone (tBHQ) induced two forms of the Nrf2 protein in neuroblastoma cells (IMR-32), which migrated as distinctive bands on SDS-PAGE. In vitro treatment with lambda phosphatase eliminated the slower migrating form of Nrf2. The phosphorylated form of Nrf2 preferentially localized in the nucleus. Deletional analyses revealed that the transcription activation (TA) domain is phosphorylated. The TA domain is characterized by the presence of multiple conserved phosphorylation sites of CK2. Treatments with CK2 inhibitor DMAT blocked the induction of endogenous target genes of Nrf2 in cells and inhibited the TA activity of Nrt2. The findings demonstrated that phosphorylation of Nrf2 at the TA domains by CK2 is an integral component of Nrf2 activation. Disclaimers-- The findings and conclusions in this abstract have not been formally disseminated by the National Institute for Occupational Safety and Health and should not be construed to represent any agency determination or policy. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHORYLATION
KW - TRANSCRIPTION factors
KW - PROTEIN kinase CK2
KW - TRANSLOCATION (Genetics)
KW - GENETIC transcription
N1 - Accession Number: 25632907; Apopa, Patrick Leo 1,2 Lin, Gary Xiong 1 Xiaoqing He 1 Qiang Ma 1; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, CDC, 1095 Willodale Rd, Morgantown, WV, 26505 2: Biochemistry and Molecular Pharmacology, West Virginia University, 3154 Health Sciences Center North, Morgantown, WV, 26506; Source Info: Apr2007, Vol. 21 Issue 5, pA287; Subject Term: PHOSPHORYLATION; Subject Term: TRANSCRIPTION factors; Subject Term: PROTEIN kinase CK2; Subject Term: TRANSLOCATION (Genetics); Subject Term: GENETIC transcription; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pei Tsai
AU - Guan-Liang Cao
AU - Merkel, Todd
AU - Rosen, Gerald
T1 - A Novel Approach Toward In Vivo EPR Imaging of B. anthracis.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/15/
VL - 21
IS - 5
M3 - Article
SP - A633
EP - A633
AB - Bacillus anthracis is a spore-forming, gram-positive organism that is the etiologic agent of anthrax. According to the current model of B. anthracis pathogenesis, B. anthacis spores enter the lungs, are phagoeytosed by host alveolar macrophages and are subsequently carried to regional lymph nodes. Spores germinate inside the host macrophages and become vegetative bacilli that are then released from the macrophages. Bacilli multiply in the lymphatic system, enter the bloodstream, and multiply to high levels, e.g., 107 - 108 organisms/mL blood. Little is known about the progression of disease following inhalation of spores. The mechanism and route of transit of B. anthracis from the lungs to distal sites in the host is not clear. With the development of low-frequency electron paramagnetic resonance (EPR) spectroscopy and the ability to detect paramagnetic species in situ, in vivo and in real time, tracking by imaging of B. anthracis endospores in living animals is now a real possibility. We designed experiments to incorporate aminoxyls into endospores using two different strategies. Herein, methods are described to spin label endospores with nitroxides at concentrations sufficient to follow endospores following aerosol infection in mice using EPR imaging. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS anthracis
KW - ELECTRON paramagnetic resonance spectroscopy
KW - NITROXIDES
KW - BACILLUS (Bacteria)
KW - SPECTRUM analysis
N1 - Accession Number: 25634589; Pei Tsai 1,2 Guan-Liang Cao 1 Merkel, Todd 3 Rosen, Gerald 1,4; Affiliation: 1: Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Baltimore, MD, 21201 2: Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Baltimore, MD, 21201 3: Center for Biologics Evaluation and Research, Food & Drug Administration, Bethesda, Bethesda, MD, 20812 4: Center for EPR Imaging for In Vivo Physiology, University of Maryland School of Pharmacy, Baltimore, Baltimore, MD, 21201; Source Info: Apr2007, Vol. 21 Issue 5, pA633; Subject Term: BACILLUS anthracis; Subject Term: ELECTRON paramagnetic resonance spectroscopy; Subject Term: NITROXIDES; Subject Term: BACILLUS (Bacteria); Subject Term: SPECTRUM analysis; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fischer, Thea Kølsen
AU - Viboud, Cécile
AU - Parashar, Umesh
AU - Malek, Mark
AU - Steiner, Claudia
AU - Glass, Roger
AU - Simonsen, Lone
T1 - Hospitalizations and Deaths from Diarrhea and Rotavirus among Children <5 Years of Age in the United States, 1993-2003.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/04/15/
VL - 195
IS - 8
M3 - Article
SP - 1117
EP - 1125
SN - 00221899
AB - Recently a new rotavirus vaccine was licensed in the United States and recommended for universal immunization of American children. The impact of the vaccine on a decrease in hospitalizations will take several years to assess and will be based on the availability of good baseline data on the disease. We used the largest US hospital discharge database available, the Healthcare Cost and Utilization Project (HCUP), to study national rates, trends, and risk factors for diarrhea- and rotavirus-associated hospitalizations and deaths amongchildren <5 years of age, to establish a baseline against which vaccine implementation can be measured. Rotavirus remained the most important cause of pediatric diarrhea throughout the study period (1993-2003). When the data were extrapolated to the US population, rotavirus was estimated to be the cause of ∼60,000 hospitalizations and 37 deaths annually. Black infants had a significantly higher risk of being hospitalized with and dying from rotavirus disease early in life, compared with white infants (risk ratio [RR] for hospitalization by 12 months of age was 2.4, with a 95% confidence interval [CI] of 1.2-4.7; RR for death was 2.0, with a 95% CI of 1.7-2.5). Such racial differences in age and risk of rotavirus-associated hospitalization and death highlight the importance of timely and early rotavirus immunization of minority children. The HCUP database serves as a sensitive and robust data source for monitoring the impact of a rotavirus-immunization program in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL care
KW - CHILDREN -- Death
KW - DEATH -- Causes
KW - DIARRHEA
KW - ROTAVIRUSES
KW - CHILDREN -- United States
KW - UNITED States
N1 - Accession Number: 24476376; Fischer, Thea Kølsen 1,2,3 Viboud, Cécile 4 Parashar, Umesh 1 Malek, Mark 1 Steiner, Claudia 5 Glass, Roger 1,4 Simonsen, Lone 6; Email Address: LSimonsen@niaid.nih.gov; Affiliation: 1: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Atlanta. 2: Epidemiology Intelligence Service, Centers for Disease Control and Prevention, Atlanta. 3: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. 4: Fogarty International Center, National Institutes of Health, Bethesda, Maryland. 5: Center for Delivery, Organization, and Markets, Agency for Health Care Research and Quality, Bethesda, Maryland. 6: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Source Info: 4/15/2007, Vol. 195 Issue 8, p1117; Subject Term: HOSPITAL care; Subject Term: CHILDREN -- Death; Subject Term: DEATH -- Causes; Subject Term: DIARRHEA; Subject Term: ROTAVIRUSES; Subject Term: CHILDREN -- United States; Subject Term: UNITED States; Number of Pages: 9p; Document Type: Article
L3 - 10.1086/512863
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Soreth, Janice
AU - Cox, Edward
AU - Kweder, Sandra
AU - Jenkins, John
AU - Galson, Steven
T1 - Ketek — The FDA Perspective.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2007/04/19/
VL - 356
IS - 16
M3 - Letter
SP - 1675
EP - 1676
SN - 00284793
AB - The article presents a letter to the editor in response to the article "The FDA and the case of Ketek," by D. B. Ross in the April 19, 2007 issue.
KW - LETTERS to the editor
KW - DRUG approval
N1 - Accession Number: 24761807; Soreth, Janice 1 Cox, Edward 1 Kweder, Sandra 1 Jenkins, John 1 Galson, Steven 1; Affiliation: 1: Center for Drug Evaluation and Research Food and Drug Administration Silver Spring, MD 20993; Source Info: 4/19/2007, Vol. 356 Issue 16, p1675; Subject Term: LETTERS to the editor; Subject Term: DRUG approval; Number of Pages: 2p; Document Type: Letter; Full Text Word Count: 577
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Terry J.
AU - Knapton, Alan
AU - Adeyemo, Oluwafunke O.
AU - Noory, Laila S.
AU - Weaver, James L.
AU - Hanig, Joseph P.
AU - Honchel, Ronald
AU - Jun Zhang
AU - Espandiari, Parvaneh
AU - Benedick, Matthew F.
AU - Umbreit, Thomas H.
AU - Tomazic-Jezic, Vesna J.
AU - Sadrieh, Nakissa
T1 - Toxicology of Titanium Dioxide (TiO2) Nanoparticles: In vitro and in vivo evaluation of macrophage uptake of TiO2.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A812
EP - A812
AB - Potential health risks from TiO2 in sunscreens and medical products remains unknown. Balb/C mice were injected IV with TiO2 in saline (size 4.7 nm, 5.6 mg/mouse/day for 2 days) and necropsied on days 3 & 5. The mice showed white discoloration of lungs, liver, and spleen, as well as phagocytosis of TiO2 aggregates by macrophages in these organs by light microscopy. Kidney and brain of treated mice appeared unchanged. To model macrophage response to TiO2 in vitro, cultured J774 cells were treated with TiO2 (0.025-6.3 mg/mL) up to 24 hours and examined for viability, oxidative stress, and cytokine production. TiO2-treated J774 cells showed dose & time dependent loss of viability via MTT assay. Increased ROS production and loss of cell membrane integrity was observed at higher TiO2 doses and longer exposure times, by fluorescence microscopy. However, antioxidants α-tocopherol & trolox failed to prevent TiO2-induced ROS and cell death, suggesting that oxidative stress may not be the predominant mechanism of TiO2 toxicity. Cytokine analysis of treated cells revealed an increased release of TNF-α, IL-1β, IL-6, and MIP-2 with increasing dose and time of exposure to TiO2. These data suggest that macrophage uptake and accumulation of large amounts of TiO2 aggregates may result in cytokine release and potential cytotoxicity in cells and tissues responsible for clearance of TiO2 from circulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TITANIUM dioxide
KW - SUNSCREENS (Cosmetics)
KW - MACROPHAGES
KW - PHAGOCYTOSIS
KW - MICE as laboratory animals
KW - CELL membranes
KW - CYTOKINES
N1 - Accession Number: 25597363; Miller, Terry J. 1 Knapton, Alan 1 Adeyemo, Oluwafunke O. 1 Noory, Laila S. 1 Weaver, James L. 1 Hanig, Joseph P. 1 Honchel, Ronald 1 Jun Zhang 1 Espandiari, Parvaneh 1 Benedick, Matthew F. 1 Umbreit, Thomas H. 2 Tomazic-Jezic, Vesna J. 2 Sadrieh, Nakissa 1; Affiliation: 1: CDER, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993 2: CDRH, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993; Source Info: Apr2007, Vol. 21 Issue 6, pA812; Subject Term: TITANIUM dioxide; Subject Term: SUNSCREENS (Cosmetics); Subject Term: MACROPHAGES; Subject Term: PHAGOCYTOSIS; Subject Term: MICE as laboratory animals; Subject Term: CELL membranes; Subject Term: CYTOKINES; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ryan, Michael James
AU - Dudash, Holly J.
AU - Docherty, Megan E.
AU - Geronilla, Kenneth B.
AU - Baker, Brent A.
AU - Cutlip, Robert G.
AU - Alway, Stephen
T1 - Effects of Antioxidant Supplementation and Repetitive Loading on Biomarkers of Oxidative Stress in Aged and Young Adult Rats.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A814
EP - A814
AB - Antioxidant supplementation has been suggested as an intervention against the deleterious effects of increased oxidative stress (OS) associated with aging. The purpose of this study was to determine the effects of different dietary antioxidant supplements on biomarkers of OS in repetitively loaded (RL) muscles in aged rats. Aged and young adult (YA) FBNxF344 rats were randomly assigned to a diet supplemented with Vit C & Vit E, curcumin, or normal non-supplemented (NS) rat chow. The dorsiflexors of the left limb in all animals were loaded 3x/wk for 4.5 wks using 80 maximal stretch-shortening contractions per session. Biomarkers of OS were measured in the tibialis anterior muscle (TA). RL increased the concentration of cytosolic H2O2 in TA muscles from aged and YA animals, but both supplements attenuated this increase. The GSH/GSSG ratio increased in the exercised limb of supplemented animals. Mn SOD activity increased with supplementation in the YA animals. CuZn SOD activity increased with supplementation in YA and aged animals and GPx activity increased with exercise in the NS YA and aged animals. Catalase activity increased with supplementation in the YA and aged animals. GPx-1, SOD-1, and catalase mRNA expression were lower in TA muscles of aged supplemented animals. These data suggests that antioxidant supplementation may improve muscle levels of OS with aging under conditions of RL. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIOXIDANTS
KW - OXIDATIVE stress
KW - BIOCHEMICAL markers
KW - RATS as laboratory animals
KW - AGING -- Animal models
KW - VITAMIN C
KW - MESSENGER RNA
KW - CATALASE
N1 - Accession Number: 25597376; Ryan, Michael James 1 Dudash, Holly J. 1 Docherty, Megan E. 2 Geronilla, Kenneth B. 3 Baker, Brent A. 3 Cutlip, Robert G. 3 Alway, Stephen 1; Affiliation: 1: Exercise Physiology, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9227, Morgantown, WV, 26506 2: Dept of Chemistry, West Virginia Wesleyan College, 59 College Ave., Buckhannon, WV, 26201 3: Health Effects Laboratory Division, CDC National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505; Source Info: Apr2007, Vol. 21 Issue 6, pA814; Subject Term: ANTIOXIDANTS; Subject Term: OXIDATIVE stress; Subject Term: BIOCHEMICAL markers; Subject Term: RATS as laboratory animals; Subject Term: AGING -- Animal models; Subject Term: VITAMIN C; Subject Term: MESSENGER RNA; Subject Term: CATALASE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cleveland, Beth M.
AU - Leonard, Stephen S.
AU - Klandorf, Hillar
AU - Blemings, Kenneth P.
T1 - Reducing urate oxidase mRNA alters the oxidative stress response in a mouse hepatic cell line.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A821
EP - A821
AB - Humans, birds, and higher primates do not express the uric acid degrading enzyme urate oxidase and, as a result, have plasma uric acid concentrations higher than urate oxidase expressing animals. Although high uric acid concentrations are suggested to increase the antioxidant defense system and provide a health advantage to animals without urate oxidase, knockout mice lacking urate oxidase develop pathological complications including gout and kidney failure. As an alternative to the knockout model, RNA interference was used to decrease urate oxidase expression in a mouse hepatic cell line (ATCC, FL83B). Cells were antibiotic selected for stable expression of a transfected plasmid that expresses a short hairpin RNA for urate oxidase knockdown. Urate oxidase mRNA was reduced 90% compared to wild type, as measured by real time RT-PCR. To determine if urate oxidase knockdown resulted in enhanced protection against oxidative stress, cells were challenged with hexavalent chromium (Cr(VI)), which generates an increased production of reactive oxygen species. Hydroxyl radicals, and possibly decomposed superoxide radicals, were quantified using electron spin resonance (ESR). Cells with urate oxidase knockdown demonstrated a 37.2 ± 3.5% reduction (p<0.05) in the ESR signal compared to wild type cells, consistent with a lower exposure to free radicals and decreased oxidative stress. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URIC acid
KW - OXIDASES
KW - ANTIOXIDANTS
KW - MESSENGER RNA
KW - GOUT
KW - CELL lines
KW - CHROMIUM
KW - MICE as laboratory animals
N1 - Accession Number: 25597407; Cleveland, Beth M. 1 Leonard, Stephen S. 2 Klandorf, Hillar 1 Blemings, Kenneth P. 1; Affiliation: 1: Animal and Vet. Sci., West Virginia University, P.O. Box 6108, Morgantown, WV, 26506 2: Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Willowdale Dr., Morgantown, WV, 26505; Source Info: Apr2007, Vol. 21 Issue 6, pA821; Subject Term: URIC acid; Subject Term: OXIDASES; Subject Term: ANTIOXIDANTS; Subject Term: MESSENGER RNA; Subject Term: GOUT; Subject Term: CELL lines; Subject Term: CHROMIUM; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peng Zhang
AU - Dan Li
AU - Ray, Radharaman
AU - Singh, Bal Ram
AU - Keller, James E.
AU - Adler, Michael
AU - Ray, Prabhati
T1 - Targeted Therapeutic Peptide Delivery to Synaptic Junctions as Botulism Countermeasure.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A1001
EP - A1001
AB - Development of an effective medical countermeasure strategy against botulinum neurotoxin (BoNT) is an urgent military mission. In this study, a targeted delivery vehicle (DV) was developed for intracellular transport of emerging BoNT antagonists. The DV consisted of Cy3-labeled recombinant BoNT/A heavy chain (rHC), which promotes internalization of the complex, coupled to an OG 488-labeled dextran served as a platform to deliver therapeutic molecules. The neuronal model was cultured mouse spinal cord neurons. Our results indicated the following: (1) no separation of DV components was observed in 1 hour DV treatment, which suggests that DV components inside neurons may not be separated immediately after the DV complex uptake; (2) The separation of DV components was observed in 12 and 24 hours DV treatments. The separation rate of DV components was increased after prolonged culture periods, the highest separation rate was observed during the 3rd week of culture; (3) all rHC uptake was localized in the endosomes and (4) dextran in DV was partially released from endosomes to the cytoplasm. In conclusion, our results suggest that the separation of the DV components inside neurons may be dependent on the status of neuronal differentiation, i.e., maturation. The DV construct used in our studies may serve as a model drug carrier in developing botulism countermeasures. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG delivery systems
KW - PEPTIDES
KW - BOTULINUM toxin
KW - NEURONS
KW - ENDOSOMES
KW - CYTOPLASM
KW - BACTERIAL toxins
KW - THERAPEUTIC use
N1 - Accession Number: 25598262; Peng Zhang 1 Dan Li 1 Ray, Radharaman 2 Singh, Bal Ram 3 Keller, James E. 4 Adler, Michael 2 Ray, Prabhati 1; Affiliation: 1: ET, walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, 2: United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD, 21010, 3: Chemistry and Biochemistry, University of Massachusetts, 285 Old Westport Rd, Dartmouth, MA, 02747, 4: U. S. Food and Drug Administration, 9000 Rockville Pike, Bethesda, MD, 20892; Source Info: Apr2007, Vol. 21 Issue 6, pA1001; Subject Term: DRUG delivery systems; Subject Term: PEPTIDES; Subject Term: BOTULINUM toxin; Subject Term: NEURONS; Subject Term: ENDOSOMES; Subject Term: CYTOPLASM; Subject Term: BACTERIAL toxins; Subject Term: THERAPEUTIC use; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaoqing He
AU - Lin, Gary X.
AU - Chen, Michael G.
AU - Qiang Ma.
T1 - Protection against Chromium (VI)-induced oxidative stress and apoptosis by Nrf2. recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keapl association by toxic metal.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A1181
EP - A1181
AB - Chromium(VI) (Cr) is a major environmental toxic metal and human carcinogen. The molecular events mediating cellular responses to Cr(VI) are not clear at present. We show that Cr(VI) potently induced apoptosis and production of reactive oxygen species (ROS) in a concentration-dependent manner. Mouse embryonic fibroblast cells lacking Nrf2 exhibited elevated ROS production and apoptosis, which were markedly further increased by Cr(VI). Protection by Nrf2 correlated with induction of cytoprotective genes Ho-1 and Nqo1. Induction of the genes by Cr(VI) involved inhibition of ubiquitination of Nrf2 and accumulation of Nrf2 into the nucleus. In the nucleus, treatment with Cr(VI), but not phenolic antioxidant tBHQ, librates Nrf2 from Nrf2/Keap1 association and recruits Nrf2 to the antioxidant response elements (ARE) located in the enhancers of Ho-1 and Nqo1. Activation of Nrf2 by Cr(VI) was accompanied by the nuclear translocation and deubiquitination of Keap1 implicating recycling of Keap1 in Nrf2 signaling. Thus, protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 signaling by toxic metal, transcription of ARE-driven genes, and reduction of ROS production. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEXAVALENT chromium -- Environmental aspects
KW - OXIDATIVE stress
KW - APOPTOSIS
KW - CARCINOGENS
KW - ACTIVE oxygen
KW - FIBROBLASTS
KW - POST-translational modification
KW - MICE as laboratory animals
N1 - Accession Number: 25599090; Xiaoqing He 1,2,3 Lin, Gary X. 1,2,3 Chen, Michael G. 1,2,3 Qiang Ma. 1,2,3; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Div., 1095 Willowdale Rd., Morgantown, WV, 26505 2: National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, 26505 3: Center for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV, 26505; Source Info: Apr2007, Vol. 21 Issue 6, pA1181; Subject Term: HEXAVALENT chromium -- Environmental aspects; Subject Term: OXIDATIVE stress; Subject Term: APOPTOSIS; Subject Term: CARCINOGENS; Subject Term: ACTIVE oxygen; Subject Term: FIBROBLASTS; Subject Term: POST-translational modification; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhiwei Zhao
AU - Yongyi Bi
AU - Ying Xia
AU - Ning Tao
AU - Qiang Ma
T1 - Differential expression of cytochrome P450 genes associated with benzene-induced hematotoxicity.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A1181
EP - A1181
AB - Benzene is an established human carcinogen and leukemogen. Chronic benzene exposure results in progressive depression of bone marrow function with increased risks of aplastic anemia, myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), chronic lymphocytic leukemia, and other disorders. The mechanism underlying benzene toxicity remains uncertain; an initial metabolism and bioactivation of benzene, especially by CYP2E1 in the liver, was considered a prerequisite. To identify CYP genes whose expression is aberrant in benzene poisoning, a cDNA microarray containing 32 CYP genes was used to detect differential expression of CYPs in patients with hematopoietic dysfunction of benzene exposure. Seven female shoemakers with hematological disorders (six cases of decreased peripheral white blood cells and one case of aplastic anemia) were recruited, and seven age- and gender-matched normal subjects were selected as controls. Total RNA from the two groups was prepared, followed by reverse transcription to cDNAs with concomitant incorporation of fluorescent dCTP (Cy3 for the patients and Cy5 for the controls). Microassay was performed. Genes with a two-fold higher/lower expression level were considered to be significant. Six CYP genes (CYP4F3, CYP1A1, CYP27A1, CYP1B1, CYP2B6, and CYP51) were found to be differentially expressed between benzene-exposed patients and controls. Among these, CYP4F3 gene was up-regulated consistently among all patients. Our study indicated that CYP4F3 is up-regulated in peripheral blood cells in bezene poisoning and may serve as a new biomarker for the exposure and poisoning of benzene. [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME P-450 CYP2E1
KW - GENE expression
KW - BENZENE
KW - CARCINOGENS
KW - BONE marrow
KW - BLOOD diseases
KW - BLOOD cells
KW - TOXICOLOGY
N1 - Accession Number: 25599089; Zhiwei Zhao 1 Yongyi Bi 1 Ying Xia 1 Ning Tao 1 Qiang Ma 2; Affiliation: 1: Occupational and Environmental Health, Wuhan University School of Public Health, 185 Donghu Rd., Wuhan, Hubei, 430071, China, People's Republic of 2: Receptor Biology Laboratory, TMBB/HELD, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Rd., Morgantown, WV, 26505; Source Info: Apr2007, Vol. 21 Issue 6, pA1181; Subject Term: CYTOCHROME P-450 CYP2E1; Subject Term: GENE expression; Subject Term: BENZENE; Subject Term: CARCINOGENS; Subject Term: BONE marrow; Subject Term: BLOOD diseases; Subject Term: BLOOD cells; Subject Term: TOXICOLOGY; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 1/5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hollander, Melinda S.
AU - Baker, Brent A.
AU - Kashon, Michael L.
AU - Cutlip, Robert G.
T1 - Inhibition of glutathione synthesis does not increase oxidative stress in response to repetitive stretch-shortening contractions.
JO - FASEB Journal
JF - FASEB Journal
Y1 - 2007/04/30/
VL - 21
IS - 6
M3 - Article
SP - A1309
EP - A1309
AB - We investigated effects of glutathione (GSH) synthesis inhibition on the oxidative stress status of tibialis anterior (TA) muscles in young (12 wk) and old (30 mo) Fisher 344 x Brown Norway F1 male rats. L-Buthionine (S,R)-sulfoximine (BSO), an inhibitor of GSH synthesis, was administered to rats in the drinking water at 10mM. Left dorsiflexor muscles of old and young rats were exposed 3 times a week for 4.5 weeks to a protocol of 80 maximal stretch-shortening contractions (SSC) per exposure in vivo. TA muscle response was characterized by measurement of malondialdehyde (MDA) as a marker of lipid peroxidation, which is used as an indicator of oxidative stress. GSH was measured to indicate effects of treatment. GSH levels were lower in BSO treated rats compared to unsupplemented rats in old and young (p < 0.05) indicating that BSO was effective in decreasing GSH. The LTA presented with a higher MDA level in old BSO treated rats compared to the RTA (p < 0.05). LTAs from old rats had higher MDA compared to young rats in the BSO, unsupplemented, and anesthesia groups (all p < 0.05). Based on our findings, it does not appear as if decreased GSH levels or prolonged anesthesia affects the oxidative stress status of the TA muscle after exposure to repetitive SSCs. Disclaimer: "Findings and conclusions in this abstract have not been formally disseminated by NIOSH and should not be taken to represent any agency determination or policy." [ABSTRACT FROM AUTHOR]
AB - Copyright of FASEB Journal is the property of Federation of American Society for Experimental Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - OXIDATIVE stress
KW - MUSCLE contraction
KW - MALONDIALDEHYDE
KW - PEROXIDATION
KW - RATS as laboratory animals
N1 - Accession Number: 25599704; Hollander, Melinda S. 1 Baker, Brent A. 1 Kashon, Michael L. 2 Cutlip, Robert G. 1; Affiliation: 1: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505 2: Biostatistics and Epidemilogy Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV, 26505; Source Info: Apr2007, Vol. 21 Issue 6, pA1309; Subject Term: GLUTATHIONE; Subject Term: OXIDATIVE stress; Subject Term: MUSCLE contraction; Subject Term: MALONDIALDEHYDE; Subject Term: PEROXIDATION; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1/4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kayentao, Kassoum
AU - Mungai, Mary
AU - Parise, Monica
AU - Kodio, Mamoudou
AU - Keita, Abdoul Salam
AU - Coulibaly, Drissa
AU - Maiga, Boubacar
AU - Traoré, Boubacar
AU - Doumbo, Ogobara K.
T1 - Assessing malaria burden during pregnancy in Mali
JO - Acta Tropica
JF - Acta Tropica
Y1 - 2007/05//
VL - 102
IS - 2
M3 - Article
SP - 106
EP - 112
SN - 0001706X
AB - Abstract: Malaria infection during pregnancy is associated with adverse consequences including low birth weight (LBW) and maternal anemia, particularly in primigravidae and secundigravidae. In preparation for a clinical trial of the efficacy of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) containing prevention regimens during pregnancy, we conducted a one-year cross sectional study in Koro and Bandiagara, Mali using an assessment methodology developed by the Centers for Disease Control and Prevention (CDC) to generate basic data on malarial burden during pregnancy. Two hundred and sixty-one and 192 women were enrolled in Koro and Bandiagara, respectively. Rates of placental parasitemia were 17.1 and 42.3% in Koro and Bandiagara, respectively, despite high (70–80%) use of preventive medication (mainly CQ). Low gravidity (1st and 2nd pregnancies) was associated with peripheral (p <0.001) and placental (p <0.001) malaria only in Bandiagara, whereas it was associated with low birth weight in both sites (p <0.001 in Koro and p =0.002 in Bandiagara). First and second pregnancies were the most important characteristics associated with placental malaria (RR=2.78, 95%CI 1.81–4.29) and (ARR=2.06, 95%CI 1.03–4.15) and low birth weight (RR=4.26, 95%CI 2.50–7.27) and (ARR=4.51, 95%CI 2.55–8.00). Birth during the rainy season was associated with placental infection in univariate analysis. Characteristics such as younger age, having fever during pregnancy, and unmarried status were associated with low birth weight only in univariate analysis and singleton premature delivery and low gravidity were associated with low birth weight in both univariate and multivariate analysis. Data from this assessment demonstrated the high burden of malaria during pregnancy in Mali. Results had been used by researchers as local reference data and by ministry of health for to stop recommending CQ prophylaxis. The methodology could be used by other malaria-endemic countries to direct their national malaria program efforts. [Copyright &y& Elsevier]
AB - Copyright of Acta Tropica is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA
KW - PREGNANT women
KW - PREGNANCY complications
KW - MALI
KW - Gravidity
KW - Low birth weight
KW - Malaria
KW - Mali
KW - Placenta
KW - Pregnancy
N1 - Accession Number: 25411793; Kayentao, Kassoum 1 Mungai, Mary 2,3 Parise, Monica 2,3 Kodio, Mamoudou 1 Keita, Abdoul Salam 1 Coulibaly, Drissa 1 Maiga, Boubacar 1 Traoré, Boubacar 1 Doumbo, Ogobara K. 1; Email Address: okd@mrtcbko.org; Affiliation: 1: Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, Malaria Research and Training Center, PO Box 1805, Bamako, Mali 2: Division of Parasitic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, Atlanta, GA, USA 3: Public Health Service, US Department of Health and Human Services, USA; Source Info: May2007, Vol. 102 Issue 2, p106; Subject Term: MALARIA; Subject Term: PREGNANT women; Subject Term: PREGNANCY complications; Subject Term: MALI; Author-Supplied Keyword: Gravidity; Author-Supplied Keyword: Low birth weight; Author-Supplied Keyword: Malaria; Author-Supplied Keyword: Mali; Author-Supplied Keyword: Placenta; Author-Supplied Keyword: Pregnancy; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.actatropica.2007.04.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105734239
T1 - Researcher praises THA as interactive data resource.
AU - Eberhardt MS
Y1 - 2007/05//2007 May-Jun
N1 - Accession Number: 105734239. Language: English. Entry Date: 20080606. Revision Date: 20150711. Publication Type: Journal Article; tables/charts; website. Journal Subset: Consumer Health; USA. Special Interest: Consumer Health; Gerontologic Care. NLM UID: 9425758.
KW - Aging
KW - Information Resources
KW - Resource Databases, Health
KW - World Wide Web
KW - Aged
KW - Centers for Disease Control and Prevention (U.S.)
KW - Internet
KW - Statistics
SP - 13
EP - 13
JO - Aging Today
JF - Aging Today
JA - AGING TODAY
VL - 28
IS - 3
CY - San Francisco, California
PB - American Society on Aging
SN - 1067-8379
AD - Captain, United States Public Health Service Office of Analysis and Epidemiology, National Center for Health Statistics, CDC, Hyattsville, MD
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UR - Related websites: www.cdc.gov/nchs/agingact.htm
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Matthew P. Longnecker
AU - Beth C. Gladen
AU - Lea A. Cupul-Uicab
AU - S. Patricia Romano-Riquer
AU - Jean-Phillipe Weber
AU - Robert E. Chapin
AU - Mauricio Hernández-Ávila
T1 - In Utero Exposure to the Antiandrogen 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in Relation to Anogenital Distance in Male Newborns from Chiapas, México.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2007/05//
VL - 165
IS - 9
M3 - Article
SP - 1015
EP - 1022
SN - 00029262
AB - The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital distance serves as a measure of fetal androgen action. The authors designed the present study to examine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males. A cross-sectional study of 781 newly delivered male infants was conducted in 2002–2003 in Chiapas, México, where DDT had recently been used for malaria control. Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother's blood was drawn. In this population, the range of serum DDE levels was large (0.8–398 μg/liter). The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth. If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIANDROGENS
KW - VINYL chloride
KW - INFANT boys
KW - CHIAPAS (Mexico)
N1 - Accession Number: 24836988; Matthew P. Longnecker 1 Beth C. Gladen 2 Lea A. Cupul-Uicab 3 S. Patricia Romano-Riquer 3 Jean-Phillipe Weber 4 Robert E. Chapin 5 Mauricio Hernández-Ávila 3; Affiliation: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 2: Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 3: Center for Population Health Research, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México 4: Toxicology Centre, National Institute of Public Health of Québec, Saint-Foy, Quebec, Canada 5: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC; Source Info: May2007, Vol. 165 Issue 9, p1015; Subject Term: ANTIANDROGENS; Subject Term: VINYL chloride; Subject Term: INFANT boys; Subject Term: CHIAPAS (Mexico); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SangWoo Tak
AU - Bruce P. Bernard
AU - Richard J. Driscoll
AU - Chad H. Dowell
T1 - Floodwater exposure and the related health symptoms among firefighters in New Orleans, Louisiana 2005The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/05//
VL - 50
IS - 5
M3 - Article
SP - 377
EP - 382
SN - 02713586
AB - Concerns over increased reports of physical health symptoms thought to be related to floodwater exposure among New Orleans firefighters prompted a health hazard evaluation of firefighters following Hurricane Katrina.A questionnaire assessing health symptoms possibly related to the response to Hurricane Katrina was administered to all New Orleans Fire Department (NOFD) personnel within 3 months of the disaster. Descriptive statistics were compiled and prevalence ratios (PR) were estimated for covariates using generalized linear models with Log link and Poisson distribution.Of the 525 firefighters who completed the questionnaire (77% participation), 201 (38%) reported one or more new‐onset respiratory symptoms, such as sinus congestion (145 [28%]), throat irritation (92 [17%]), and cough (124 [24%]). Skin rash was reported by 258 (49%) of respondents, 414 (79%) reported skin contact with floodwater, and 165 (32%) reported contact with floodwater on multiple days. In multivariate analyses adjusting for age, gender, and smoking, firefighters who had floodwater contact with skin and either nose/mouth or eyes (224, 44%) had an increased rate of new‐onset upper respiratory symptoms (PR = 1.9; 95% confidence interval [CI], 1.1, 3.1), and skin rash (PR = 2.1; 95% CI, 1.4, 3.2) compared to those not exposed to the floodwater.Response workers involved with floodwater should minimize direct skin and mucosal contact with floodwater if possible through the use of appropriate personal protective equipment, such as goggles, safety glasses with side shields, or full‐face shields. Am. J. Ind. Med. 50:377–382, 2007. © 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fire fighters
KW - Regression analysis
KW - Fire departments
KW - Louisiana
N1 - Accession Number: 24890205; SangWoo Tak 1,2; Bruce P. Bernard 1; Richard J. Driscoll 1; Chad H. Dowell 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia; Issue Info: May2007, Vol. 50 Issue 5, p377; Subject Term: Fire fighters; Subject Term: Regression analysis; Subject Term: Fire departments; Subject: Louisiana; NAICS/Industry Codes: 912140 Provincial fire-fighting services; NAICS/Industry Codes: 922160 Fire Protection; NAICS/Industry Codes: 913140 Municipal fire-fighting services; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tierney, William M.
AU - Oppenheimer, Caitlin C.
AU - Hudson, Brenda L.
AU - Benz, Jennifer
AU - Finn, Amy
AU - Hickner, John M.
AU - Lanier, David
AU - Gaylin, Daniel S.
T1 - A National Survey of Primary Care Practice-Based Research Networks.
JO - Annals of Family Medicine
JF - Annals of Family Medicine
Y1 - 2007/05//May/Jun2007
VL - 5
IS - 3
M3 - Article
SP - 242
EP - 250
PB - Annals of Family Medicine
SN - 15441709
AB - The article focuses on the study that investigates the status and potential value of primary care Practice-Based Research Networks (PBRNs) operation from 2003 to 2004 in the U.S. The researchers have conducted a web-based survey and structured interviews with PBRN administrative officers and assessment of PBRN. The study determined that primary care PBRNs in the U.S. are primarily young, diverse and pursuing a variety of research directions.
KW - PRIMARY care (Medicine)
KW - INTERNET research
KW - HEALTH services administration
KW - INFORMATION networks
KW - MEDICAL care -- Research
KW - UNITED States
N1 - Accession Number: 25372677; Tierney, William M. 1,2; Email Address: wtierney@iupui.edu Oppenheimer, Caitlin C. 3,4 Hudson, Brenda L. 1 Benz, Jennifer 4 Finn, Amy 1 Hickner, John M. 4 Lanier, David 5 Gaylin, Daniel S. 3,4; Affiliation: 1: Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Ind 2: Regenstrief Institute, Inc, Indianapolis, Ind 3: National Opinion Research Center, Washington, DC 4: Department of Family Medicine, University of Chicago, Chicago, Ill 5: Agency for Healthcare Research and Quality, Gaithersburg, Md; Source Info: May/Jun2007, Vol. 5 Issue 3, p242; Subject Term: PRIMARY care (Medicine); Subject Term: INTERNET research; Subject Term: HEALTH services administration; Subject Term: INFORMATION networks; Subject Term: MEDICAL care -- Research; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Document Type: Article
L3 - 10.1370/afm.699
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lynn, Joanne
AU - Baily, Mary Ann
AU - Bottrell, Melissa
AU - Jennings, Bruce
AU - Levine, Robert J.
AU - Davidoff, Frank
AU - Casarett, David
AU - Corrigan, Janet
AU - Fox, Ellen
AU - Wynia, Matthew K.
AU - Agich, George J.
AU - O'Kane, Margaret
AU - Speroff, Theodore
AU - Schyve, Paul
AU - Batalden, Paul
AU - Tunis, Sean
AU - Berlinger, Nancy
AU - Cronenwett, Linda
AU - Fitzmaurice, J. Michael
AU - Dubler, Nancy Neveloff
T1 - The Ethics of Using Quality Improvement Methods in Health Care.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/05//5/1/2007
VL - 146
IS - 9
M3 - Article
SP - 666
EP - W161
SN - 00034819
AB - Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities designed to bring about immediate improvements in health care delivery in particular settings and concluded that QI is an intrinsic part of normal health care operations. Both clinicians and patients have an ethical responsibility to participate in QI, provided that it complies with specified ethical requirements. Most QI activities are not human subjects research and should not undergo review by an institutional review board; rather, appropriately calibrated supervision of QI activities should be part of professional supervision of clinical practice. The group formulated a framework that would use key characteristics of a project and its context to categorize it as QI, human subjects research, or both, with the potential of a customized institutional review board process for the overlap category. The group recommended a period of innovation and evaluation to refine the framework for ethical conduct of QI and to integrate that framework into clinical practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - QUALITY of service
KW - MEDICAL ethics
KW - MEDICAL research
KW - HUMAN beings
KW - CLINICAL medicine
N1 - Accession Number: 24912366; Lynn, Joanne 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Baily, Mary Ann 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16; Email Address: bailym@thehastingscenter.org Bottrell, Melissa 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Jennings, Bruce 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Levine, Robert J. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Davidoff, Frank 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Casarett, David 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Corrigan, Janet 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Fox, Ellen 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Wynia, Matthew K. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Agich, George J. 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 O'Kane, Margaret 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Speroff, Theodore 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Schyve, Paul 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Batalden, Paul 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Tunis, Sean 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Berlinger, Nancy 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Cronenwett, Linda 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Fitzmaurice, J. Michael 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16 Dubler, Nancy Neveloff 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16; Affiliation: 1: RAND Corporation, Arlington, Virginia 2: National Quality Forum, Veterans Health Administration and National Committee for Quality Assurance, Washington, DC 3: Hastings Center, Garrison, New York 4: Montefiore Medical Center, Bronx, New York 5: Veterans Health Administration, Seattle, Washington 6: Yale University, New Haven, Connecticut; Institute for Healthcare Improvement, Cambridge, Massachusetts 7: Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 8: American Medical Association, Chicago, Illinois 9: Joint Commission on Accreditation of Healthcare Organizations, Oakbrook Terrace, Illinois 10: Bowling Green State University, Bowling Green, Ohio 11: Vanderbilt University Medical Center, Nashville, Tennessee 12: Dartmouth Medical School, Hanover, New Hampshire 13: Health Tech, San Francisco, California 14: University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 15: Agency for Healthcare Research and Quality, Rockville, Maryland 16: Intermountain Institute for Health Care Delivery Research, Salt Lake City, Utah; Source Info: 5/1/2007, Vol. 146 Issue 9, p666; Subject Term: MEDICAL care; Subject Term: QUALITY of service; Subject Term: MEDICAL ethics; Subject Term: MEDICAL research; Subject Term: HUMAN beings; Subject Term: CLINICAL medicine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jae-Ho Shin
AU - Hyun Ju Moon
AU - Il Hyun Kang
AU - Tae Sung Kim
AU - Su Jung Lee
AU - Ji Youn Ahn
AU - Bae, Hoon
AU - Eui Bae Jeung
AU - Soon Young Han
T1 - OECD validation of the rodent Hershberger assay using three reference chemicals; 17α-methyltestosterone, procymidone, and p, p′-DDE.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2007/05//
VL - 81
IS - 5
M3 - Article
SP - 309
EP - 318
SN - 03405761
AB - The rodent Hershberger assay is being validated as an in vivo test method for detecting androgenic or antiandrogenic compounds by the Organization for Economic Cooperation and Development (OECD). As part of the international validation work, we studied 17α-methyltestosterone for evaluating androgenic activity, and procymidone and p,p′-DDE for evaluating antiandrogenic activity. Male Sprague–Dawley rats were castrated at postnatal day 42, and only the rats that showed preputial separation were used in this study. Seven days after castration, chemicals were administered daily by gavages to groups of rats for 10 days, as recommended by OECD phase-2 protocol. Administration of 17α-methyltestosterone induced increases of weights of accessory sex tissues and glands in a dose-dependent manner. Administration of procymidone and p,p′-DDE produced a dose-dependent decrease of weights of accessory sex tissues and glands in the rats co-treated with testosterone propionate (0.4 mg/kg/day) subcutaneously. Our data strongly suggested that the current protocol of OECD Hershberger assay (phase-2) should be used as a reliable method for the detection of endocrine related toxicity of other chemicals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANDROGENS
KW - RATS as laboratory animals
KW - TISSUES
KW - TESTOSTERONE
KW - ENDOCRINE glands
KW - 17α-methyltestosterone
KW - Hershberger assay
KW - OECD evaluation
KW - p
KW - p'-DDE
KW - p, p′-DDE
KW - Procymidone
N1 - Accession Number: 24962400; Jae-Ho Shin 1; Email Address: jaehoshin@hanmir.com Hyun Ju Moon 1 Il Hyun Kang 1 Tae Sung Kim 1 Su Jung Lee 1 Ji Youn Ahn 1 Bae, Hoon 1 Eui Bae Jeung 2 Soon Young Han 1,2; Email Address: soonyoungh@kfda.go.kr; Affiliation: 1: Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, South Korea 2: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361-763, South Korea; Source Info: May2007, Vol. 81 Issue 5, p309; Subject Term: ANDROGENS; Subject Term: RATS as laboratory animals; Subject Term: TISSUES; Subject Term: TESTOSTERONE; Subject Term: ENDOCRINE glands; Author-Supplied Keyword: 17α-methyltestosterone; Author-Supplied Keyword: Hershberger assay; Author-Supplied Keyword: OECD evaluation; Author-Supplied Keyword: p; Author-Supplied Keyword: p'-DDE; Author-Supplied Keyword: p, p′-DDE; Author-Supplied Keyword: Procymidone; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1007/s00204-006-0174-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24962400&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nicholson, Joanne
T1 - Helping parents with mental illness.
JO - Behavioral Healthcare
JF - Behavioral Healthcare
Y1 - 2007/05//
VL - 27
IS - 5
M3 - Article
SP - 32
EP - 33
SN - 19317093
AB - The article encourages addiction treatment providers in the U.S. to consider the family roles of mentally-ill clients who are parents themselves. Providers teach skills and coping mechanism that revolve only around individual issues rather than on family roles. The Family Options intervention tested at Employment Options Inc. provides parents with mental illness and their families with appropriate tools based on studies in the adult and child mental health fields.
KW - FAMILY services
KW - THERAPEUTIC communities
KW - FAMILIES
KW - MENTAL health
KW - MENTALLY ill -- Services for
KW - CHILD mental health
KW - UNITED States
N1 - Accession Number: 25269383; Nicholson, Joanne 1; Email Address: Joanne.nicholson@umassmed.edu; Affiliation: 1: Professor of Psychiatry, Center for Mental Health Services Research, Department of psychiatry, University of Massachusetts Medical School; Source Info: May2007, Vol. 27 Issue 5, p32; Subject Term: FAMILY services; Subject Term: THERAPEUTIC communities; Subject Term: FAMILIES; Subject Term: MENTAL health; Subject Term: MENTALLY ill -- Services for; Subject Term: CHILD mental health; Subject Term: UNITED States; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105923491
T1 - Helping parents with mental illness: providers often do not take into account adult consumers' family roles.
AU - Nicholson J
Y1 - 2007/05//
N1 - Accession Number: 105923491. Language: English. Entry Date: 20080111. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 101269325.
KW - Children of Impaired Parents
KW - Family Centered Care
KW - Mental Disorders -- Therapy
KW - Adult
KW - Child
KW - Family Therapy
KW - Massachusetts
KW - Parent-Child Relations
KW - Program Development
SP - 32
EP - 33
JO - Behavioral Healthcare
JF - Behavioral Healthcare
JA - BEHAV HEALTHC
VL - 27
IS - 5
CY - New York, New York
PB - Vendome Group LLC
SN - 1931-7093
AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, USA. joanne.nicholson@umassmed.edu
U2 - PMID: 17958243.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106201528
T1 - Tests for radio frequency interference to medical telemetry operating in the Private Land Mobile Radio Service (PLMRS) from newly allocated PLMRS channels.
AU - Witters D
AU - Ruggera P
AU - Witters, Donald
AU - Ruggera, Paul
Y1 - 2007/05//May/Jun2007
N1 - Accession Number: 106201528. Language: English. Entry Date: 20071130. Revision Date: 20161117. Publication Type: journal article; equations & formulas; research; tables/charts; tracings. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 8905560.
KW - Patient Safety
KW - Radio Waves
KW - Telemetry -- Equipment and Supplies
KW - Evaluation Research
KW - Hospitals
KW - Wireless Communications
KW - Human
SP - 244
EP - 251
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 41
IS - 3
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - Radio frequency interference (RFI) is a well-known risk for wireless 'medical telemetry, particularly for older telemetry systems still operating in the Private Land Mobile Radio Service (PLMRS) frequencies between 450 and 410 MHz. Testing was performed with medical telemetry systems at two local hospitals using the older 25 kHz wide, 460 to 410 MHz channel PLMRS telemetry to assess the RFI potential with transmissions using newly allocated 12.5 kHz and 6.25 kHz wide channels. Significant interference and loss of telemetry was observed on the telemetry monitors when the new channels both overlapped with and were adjacent to the medical telemetry channels. This work demonstrates the vulnerability of older medical telemetry using the radio frequencies between 460 and 410 MHz to new PLMRS transmitters that will operate in these frequencies after December 31, 2005. Telemetry users are urged to assess their equipment RFI vulnerabilities, particularly in the PLMRS frequency band, and migrate to frequencies with less risk of RFI such as the Wireless Medical Telemetry Service (WMTS).
SN - 0899-8205
AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852, USA
U2 - PMID: 17582964.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baso-Cejas, E.
AU - Brito, G.
AU - Díaz, C.
AU - Peña-Méndez, E.
T1 - Determination of Inorganic Bromide Content in Several Vegetable Foods.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 2007/05//
VL - 78
IS - 5
M3 - Article
SP - 417
EP - 420
PB - Springer Science & Business Media B.V.
SN - 00074861
AB - The phenol red spectrophotometric method has been studied and applied as an inexpensive screening method for the determination of bromide in vegetables samples. The concentration of bromide ranged from 3.65 to 14.42 mg kg−1 in capsicum, 4.50 to 9.30 mg kg−1 in potatoes, and 3.63 to 19.02 mg kg−1 in fungi. The content of inorganic bromide in the studied vegetables was found to be below the maximum concentration of residues established by Spanish legislation (20 mg kg−1). [ABSTRACT FROM AUTHOR]
AB - Copyright of Bulletin of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vegetables
KW - Potatoes
KW - Peppers
KW - Fungi
KW - Analytical chemistry
KW - Bromides -- Environmental aspects
KW - Spectrophotometry
KW - Spain
KW - fungi
KW - Inorganic bromide
KW - pepper
KW - potatoes
KW - red phenol method
N1 - Accession Number: 25917023; Baso-Cejas, E. 1; Brito, G. 2; Díaz, C. 1; Peña-Méndez, E. 1; Email Address: empena@ull.es; Affiliations: 1: Department of Analytical Chemistry, Nutrition and Food Science , University of La Laguna , La Laguna 38071 Spain; 2: Department of Health, Canary Islands Public Health Service , Canary Government , 38004-S/C de Tenerife Tenerife Spain; Issue Info: May2007, Vol. 78 Issue 5, p417; Thesaurus Term: Vegetables; Thesaurus Term: Potatoes; Thesaurus Term: Peppers; Thesaurus Term: Fungi; Thesaurus Term: Analytical chemistry; Subject Term: Bromides -- Environmental aspects; Subject Term: Spectrophotometry; Subject: Spain; Author-Supplied Keyword: fungi; Author-Supplied Keyword: Inorganic bromide; Author-Supplied Keyword: pepper; Author-Supplied Keyword: potatoes; Author-Supplied Keyword: red phenol method; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111211 Potato Farming; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 4p; Document Type: Article
L3 - 10.1007/s00128-007-9212-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kocabas, Can
AU - Katsenelson, Nora
AU - Kanswal, Sunita
AU - Kennedy, Margaret N.
AU - Xinle Cui
AU - Blake, Milan S.
AU - Segal, David M.
AU - Akkoyunlu, Mustafa
T1 - Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14.
JO - Cellular Microbiology
JF - Cellular Microbiology
Y1 - 2007/05//
VL - 9
IS - 5
M3 - Article
SP - 1297
EP - 1310
PB - Wiley-Blackwell
SN - 14625814
AB - Encapsulated Neisseria meningitidis can invade mucosal barriers and cause systemic diseases. Activation of the innate immune system by conserved meningococcal molecules such as lipooligosaccharides (LOS) is essential for the generation of an effective host immune response. Here we show that the type C capsular polysaccharide of N. meningitidis (MCPS) inhibited LOS-induced interleukin-6 and TNF-α secretion from monocytes, and blocked the maturation of dendritic cells induced by LOS, while the capsular polysaccharide from group B streptococcus type III and t(4-hydroxy-3-nitrophenyl) acetyl (NP)-Ficoll had no such effect. MCPS also inhibited the LOS-induced NF-κB activation and phosphorylation of signalling molecules such as ERK1/2, p38 and Jun N-terminal kinase. In a direct binding assay, MCPS manifested a concentration-dependent binding to recombinant lipoprotein binding protein and CD14, the two members of the LOS receptor complex. In addition, the binding of LOS to CD14 and lipopolysaccharide binding protein was inhibited by MCPS. We established that MCPS binding to CD14 is responsible for the inhibition of LOS-mediated cell activation because MCPS inhibition of LOS was reversed when access amounts of CD14 were added to culture media of HEK293 cells expressing TLR4 and MD-2, and the magnitude of recovery in LOS stimulation correlated with the increase in CD14 concentration. These results suggest a new virulence property of meningococcal capsular polysaccharides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - MUCOUS membrane -- Diseases
KW - POLYSACCHARIDE synthesis
KW - LIPOPROTEIN antibodies
KW - ANTIGEN-antibody reactions
KW - GENE expression
N1 - Accession Number: 24594852; Kocabas, Can 1 Katsenelson, Nora 1 Kanswal, Sunita 1 Kennedy, Margaret N. 2 Xinle Cui 1 Blake, Milan S. 1 Segal, David M. 2 Akkoyunlu, Mustafa 1; Email Address: Mustafa.Akkoyunlu@fda.hhs.gov; Affiliation: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, U. S. Food and Drug Administration, 1410 Rockville Pike (HFM-428), Rockville, MD 20852-1448, USA 2: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: May2007, Vol. 9 Issue 5, p1297; Subject Term: NEISSERIA meningitidis; Subject Term: MUCOUS membrane -- Diseases; Subject Term: POLYSACCHARIDE synthesis; Subject Term: LIPOPROTEIN antibodies; Subject Term: ANTIGEN-antibody reactions; Subject Term: GENE expression; Number of Pages: 14p; Illustrations: 8 Graphs; Document Type: Article
L3 - 10.1111/j.1462-5822.2006.00872.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsai, Chen-An
AU - Chen, James J.
T1 - Kernel estimation for adjusted -values in multiple testing
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2007/05//
VL - 51
IS - 8
M3 - Article
SP - 3885
EP - 3897
SN - 01679473
AB - Abstract: Multiple testing procedures are frequently applied to biomedical and genomic research, for instance, identification of differentially expressed genes in microarray experiments. Resampling methods are commonly used to compute adjusted -values in multiple hypothesis testing problems. Importantly, the resampling-based multiple testing procedures are sensitive to the number of permutations, especially for the MinP adjustment procedure. The single-step MinP adjusted -values are derived from the distribution of the minimum of the -values. Because of computational complexity, the adjusted -values are often computed using the distribution of the maximum of the test statistics (MaxT). This paper proposes an approach based on the kernel density estimation (KDE) technique to reduce the number of permutations for implementing the single-step MinP adjustment. Simulation studies are conducted to demonstrate that the KDE method is more powerful than the MinP adjustment method under independent and correlated models. The three resampling-based single-step adjustment procedures, MaxT, MinP, and KDE, are applied to two published microarray data sets, the colon tumor data set consisting of 40 tumor and 22 normal colon tissue samples on 2000 human genes (endpoints) and the leukemia data set consisting of 27 acute lymphoblastic leukemia and 11 acute myeloid leukemia samples on 3051 genes. The MaxT adjusted -values are very robust to the number of permutations. The MaxT adjusted -values are stable with 10,000 permutations, while the MinP adjusted -values are step functions. As the number of permutations increases, the number of ties decrease. The adjusted -values are stable with 500,000 permutations. For the KDE method, the adjusted -values are stable at 50,000 permutations. At 1000,000 permutations, the three procedures have similar adjusted -values. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERMUTATIONS
KW - RESAMPLING (Statistics)
KW - STATISTICS
KW - COMPUTATIONAL complexity
KW - Family-wise error rate (FWER)
KW - Kernel density estimation
KW - Maximal test-statistic
KW - Minimal -values
KW - Permutation test
N1 - Accession Number: 24542305; Tsai, Chen-An 1 Chen, James J. 2; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA; Source Info: May2007, Vol. 51 Issue 8, p3885; Subject Term: PERMUTATIONS; Subject Term: RESAMPLING (Statistics); Subject Term: STATISTICS; Subject Term: COMPUTATIONAL complexity; Author-Supplied Keyword: Family-wise error rate (FWER); Author-Supplied Keyword: Kernel density estimation; Author-Supplied Keyword: Maximal test-statistic; Author-Supplied Keyword: Minimal -values; Author-Supplied Keyword: Permutation test; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.csda.2006.03.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Frasch, H. Frederick
AU - Barbero, Ana M.
AU - Alachkar, Houda
AU - McDougal, James N.
T1 - Skin Penetration And Lag Times Of Neat And Aqueous Diethyl Phthalate, 1,2-Dichloroethane And Naphthalene.
JO - Cutaneous & Ocular Toxicology
JF - Cutaneous & Ocular Toxicology
Y1 - 2007/05//
VL - 26
IS - 2
M3 - Article
SP - 147
EP - 160
PB - Taylor & Francis Ltd
SN - 15569527
AB - Cutaneous exposures to occupational chemicals may cause toxic effects. For any chemical, the potential for systemic toxicity from dermal exposure depends on its ability to penetrate the skin. Most laboratory studies measure chemical penetration from an aqueous solution through isolated human or laboratory animal skin, although most exposures are not from pure aqueous solutions. The US EPA Interagency Testing Committee (ITC) mandated by the Toxic Substances Control Act, has required industry to measure the in vitro penetration of 34 chemicals in their pure or neat form (if liquid). The goal of the present study was to measure skin permeability and lag time for three neat chemicals of industrial importance, representing the general types of chemicals to be studied by the ITC (non-volatile liquids, volatile liquids, and solids), and to examine interlaboratory variation from these studies. Steady state fluxes and lag times of diethyl phthalate (DEP, slightly volatile), 1,2-dichloroethane (DCE, highly volatile), and naphthalene (NAP, solid) were studied in two different laboratories using different analytical methods. One lab also measured fluxes and lag times from saturated aqueous vehicle. Static diffusion cells, dermatomed hairless guinea pig skin, and gas chromatography were used to measure skin penetration. In the two laboratories, the steady state fluxes (mean±SD; µg cm-2hour-1) of DEP applied neat were: 11.8±4.1 and 23.9±7.0; fluxes of DCE (neat) were 6280±1380 and 3842±712; fluxes of NAP from powder were 30.4±2.0 and 7.5±4.7. Compared with neat fluxes measured in the same laboratory, flux from saturated aqueous solution was higher with DEP (1.9 ×) but lower with DCE (0.17 ×) and NAP (0.45 ×). The three chemicals studied including a dry powder, demonstrate the potential for significant dermal penetration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicology
KW - Toxicological chemistry
KW - Hazardous substances
KW - Poisons
KW - Clinical toxicology
KW - Diffusion
KW - Hairless guinea pig
KW - Maximum flux
KW - Permeability
KW - Skin absorption
N1 - Accession Number: 25726927; Frasch, H. Frederick 1; Email Address: hbf9@cdc.gov; Barbero, Ana M. 1; Alachkar, Houda 2; McDougal, James N. 2; Affiliations: 1: Health Effects Laboratory, National Institute for Occupational Safety and Health. Morgantown, West Virginia; 2: Department of Pharmacology and Toxicology, Wright State University. Dayton, Ohio; Issue Info: 2007, Vol. 26 Issue 2, p147; Thesaurus Term: Toxicology; Thesaurus Term: Toxicological chemistry; Thesaurus Term: Hazardous substances; Thesaurus Term: Poisons; Subject Term: Clinical toxicology; Author-Supplied Keyword: Diffusion; Author-Supplied Keyword: Hairless guinea pig; Author-Supplied Keyword: Maximum flux; Author-Supplied Keyword: Permeability; Author-Supplied Keyword: Skin absorption; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 14p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15569520701212274
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25726927&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY -
AU - Claycamp, H. Gregg1, gregg.claycamp@fda.hhs.gov
T1 - Perspective on Quality Risk Management of Pharmaceutical Quality.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/05//
Y1 - 2007/05//
VL - 41
IS - 3
CP - 3
M3 - Article
SP - 353
EP - 367
SN - 00928615
AB - Quality risk management for the pharmaceutical industry was recently defined in internationally harmonized guidance as a systematic process for the assessment, control, communication, and review of risks to the quality of the drug product across the product life cycle. Two overarching principles for quality risk management are that evaluations of risk should be scientifically based and ultimately linked to risk to the patient, and the level of effort and documentation of quality risk management processes should be commensurate with the level of risk. Numerous tools for risk management come from other applied sciences and manufacturing having a longer history of risk management. The degree of quantitative sophistication among tools varies from generalized and qualitative, "high-level" tools to computationally rigorous, "low-level," quantitative tools. Risk is described in -- recent guidance as a combination of the probability of occurrence of harm and the severity of that harm. Risk management always comes with uncertainty, given that it calls for projections of the likelihood of adverse events for given severities. As a relatively new application of risk management, quality risk management can benefit from adapting existing theory and practice to pharmaceutical manufacturing. [ABSTRACT FROM AUTHOR]
KW - Risk management in business
KW - Quality assurance
KW - Drugs
KW - Quality of products
KW - Pharmaceutical industry
KW - Product life cycle
KW - CGMP
KW - FMEA
KW - Quality risk management
KW - Risk assessment
KW - Uncertainty
KW - Variability
N1 - Accession Number: 25189173; Authors: Claycamp, H. Gregg 1 Email Address: gregg.claycamp@fda.hhs.gov; Affiliations: 1: Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation Rockville, Maryland; Subject: Risk management in business; Subject: Quality assurance; Subject: Drugs; Subject: Quality of products; Subject: Pharmaceutical industry; Subject: Product life cycle; Author-Supplied Keyword: CGMP; Author-Supplied Keyword: FMEA; Author-Supplied Keyword: Quality risk management; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Uncertainty; Author-Supplied Keyword: Variability; Number of Pages: 15p; Illustrations: 2 Diagrams, 1 Graph; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Brinker, Allen
AU - Schech, Stephanie D.
AU - Burgess, Margaret
AU - Avigan, Mark
T1 - An Observational Study of Cholecystectomy in Patients Receiving Tegaserod.
JO - Drug Safety
JF - Drug Safety
Y1 - 2007/05//
VL - 30
IS - 7
M3 - Article
SP - 581
EP - 588
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - BACKGROUND: Registrational studies of patients treated with tegaserod for irritable bowel syndrome (IBS) suggest an increased risk for cholecystectomy versus treatment with placebo. OBJECTIVE: To study cholecystectomy rates in association with tegaserod within a large administrative medical claims database. METHODS: Patients were drawn from a large population within the US with commercial medical insurance. The primary analysis consisted of a comparison of the observed incidence rate for cholecystectomy claims among a large cohort of new-to-therapy tegaserod users with an incidence rate published for tegaserod-naive patients classified with IBS within the same insured population. RESULTS: An inception cohort of 7475 individuals with up to 103 weeks of claims history following initiation of therapy with tegaserod was identified. After a follow-up of 3 months (and thus similar to the longest registrational trials), the observed cholecystectomy incidence rate was 340 per 10 000 person-years (95% CI 258, 442). The rate of cholecystectomy was highest in the earliest months of observation following initiation of tegaserod. The observed cholecystecomy incidence rate is 2.9 times higher than an IBS-specific rate of 119 per 10 000 person-years as published for patients so classified within the same insured population. CONCLUSION: Based on a large, inception cohort, we report a strong temporal association between the initiation of tegaserod therapy and an increased rate for cholecystectomy. The effect size at 3 months was similar to the relative risk for cholecystectomy reported in registrational studies comparing tegaserod with placebo. As misclassification of initial diagnosis for patients presenting with biliary colic-like symptoms may occur, precise measurements of tegaserod-related relative risk for cholecystectomy from observational studies are problematic and will require prospective studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHOLECYSTECTOMY
KW - IRRITABLE colon
KW - THERAPEUTICS
KW - PLACEBOS (Medicine)
KW - ADMINISTRATION of drugs
KW - INSURANCE
KW - DIAGNOSIS
KW - CLINICAL trials
KW - UNITED States
N1 - Accession Number: 25740045; Brinker, Allen 1; Email Address: allen.brinker@fda.hhs.gov Schech, Stephanie D. 2 Burgess, Margaret 2 Avigan, Mark 1; Affiliation: 1: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA 2: Center for Health Care Policy and Evaluation, Eden Prairie, Minnesota, USA; Source Info: 2007, Vol. 30 Issue 7, p581; Subject Term: CHOLECYSTECTOMY; Subject Term: IRRITABLE colon; Subject Term: THERAPEUTICS; Subject Term: PLACEBOS (Medicine); Subject Term: ADMINISTRATION of drugs; Subject Term: INSURANCE; Subject Term: DIAGNOSIS; Subject Term: CLINICAL trials; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cummings, Kristin J.
AU - Cox-Ganser, Jean
AU - Riggs, Margaret A.
AU - Edwards, Nicole
AU - Kreiss, Kathleen
T1 - Respirator donning in post-hurricane New Orleans.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/05//
VL - 13
IS - 5
M3 - journal article
SP - 700
EP - 707
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We evaluated correctness of N95 filtering facepiece respirator donning by the public in post-hurricane New Orleans, where respirators were recommended for mold remediation. We randomly selected, interviewed, and observed 538 participants, using multiple logistic regression for analysis. Only 129 (24%) participants demonstrated proper donning. Errors included nose clip not tightened (71%) and straps incorrectly placed (52%); 22% put on the respirator upside down. Factors independently associated with proper donning were as follows: ever having used a mask or respirator (odds ratio [OR] 5.28; 95% confidence interval [CI], 1.79-22.64); ever having had a respirator fit test (OR 4.40; 95% CI, 2.52-7.81); being male (OR 2.44; 95% CI, 1.50-4.03); Caucasian race (OR 2.09; 95% CI, 1.32-3.33); having a certified respirator (OR 1.99, 95% CI, 1.20-3.28); and having participated in mold clean-up (OR 1.82; 95% CI,1.00-3.41). Interventions to improve respirator donning should be considered in planning for influenza epidemics and disasters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Molds (Fungi) -- Control
KW - Environmental remediation
KW - Public health
KW - Hurricanes
KW - Comparative studies
KW - Research
KW - Breathing apparatus
KW - Mycoses -- Prevention
KW - Inhalation injuries -- Prevention
KW - Disasters
KW - Research -- Methodology
KW - Medical cooperation
KW - Evaluation -- Research
KW - Acquisition of data
KW - Cross-sectional method
KW - Medical device reliability
KW - New Orleans (La.)
KW - Louisiana
N1 - Accession Number: 25079785; Cummings, Kristin J. 1,2; Email Address: cvx5@cdc.gov; Cox-Ganser, Jean 1; Riggs, Margaret A. 2,3; Edwards, Nicole 1; Kreiss, Kathleen 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Centers for Disease Control and Prevention Epidemic Intelligence Service, Atlanta, Georgia, USA; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: May2007, Vol. 13 Issue 5, p700; Thesaurus Term: Molds (Fungi) -- Control; Thesaurus Term: Environmental remediation; Thesaurus Term: Public health; Thesaurus Term: Hurricanes; Thesaurus Term: Comparative studies; Thesaurus Term: Research; Subject Term: Breathing apparatus; Subject Term: Mycoses -- Prevention; Subject Term: Inhalation injuries -- Prevention; Subject Term: Disasters; Subject Term: Research -- Methodology; Subject Term: Medical cooperation; Subject Term: Evaluation -- Research; Subject Term: Acquisition of data; Subject Term: Cross-sectional method; Subject Term: Medical device reliability; Subject: New Orleans (La.); Subject: Louisiana; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 8p; Document Type: journal article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aarestrup, Frank M.
AU - Hendriksen, Rene S.
AU - Lockett, Jana
AU - Gay, Katie
AU - Teates, Kathryn
AU - McDermott, Patrick F.
AU - White, David G.
AU - Hasman, Henrik
AU - Sørensen, Gitte
AU - Bangtrakulnonth, Aroon
AU - Pornreongwong, Srirat
AU - Pulsrikarn, Chaiwat
AU - Angulo, Frederick J.
AU - Gerner-Smidt, Peter
T1 - International Spread of Multidrug-resistant Salmonella Schwarzengrund in Food Products.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/05//
VL - 13
IS - 5
M3 - Article
SP - 726
EP - 731
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We compared 581 Salmonella enterica serotype Schwarzengrund isolates from persons, food, and food animals in Denmark, Thailand, and the United States by antimicrobial drug susceptibility and pulsed-field gel electrophoresis (PFGE) typing. Resistance, including resistance to nalidixic acid, was frequent among isolates from persons and chickens in Thailand, persons in the United States, and food imported from Thailand to Denmark and the United States. A total of 183 PFGE patterns were observed, and 136 (23.4%) isolates had the 3 most common patterns. Seven of 14 isolates from persons in Denmark had patterns found in persons and chicken meat in Thailand; 22 of 390 human isolates from the United States had patterns found in Denmark and Thailand. This study suggests spread of multidrug-resistant S. Schwarzengrund from chickens to persons in Thailand, and from imported Thai food products to persons in Denmark and the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food pathogens
KW - Foodborne diseases
KW - Drug resistance
KW - Electrophoresis
KW - Denmark
KW - United States
KW - Thailand
N1 - Accession Number: 25079789; Aarestrup, Frank M. 1; Email Address: faa@food.dtu.dk; Hendriksen, Rene S. 1; Lockett, Jana 2; Gay, Katie 2; Teates, Kathryn 2,3; McDermott, Patrick F. 4; White, David G. 1; Hasman, Henrik 1; Sørensen, Gitte 1; Bangtrakulnonth, Aroon 5; Pornreongwong, Srirat 5; Pulsrikarn, Chaiwat 5; Angulo, Frederick J. 2; Gerner-Smidt, Peter 6; Affiliations: 1: National Food Institute, Copenhagen, Denmark; 2: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: Atlanta Research and Education Foundation, Atlanta, Georgia, USA; 4: US Food and Drug Administration, Laurel, Maryland, USA; 5: Ministry of Public Health, Bangkok, Thailand; 6: Statens Serum Institut, Copenhagen, Denmark; Issue Info: May2007, Vol. 13 Issue 5, p726; Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Foodborne diseases; Subject Term: Drug resistance; Subject Term: Electrophoresis; Subject: Denmark; Subject: United States; Subject: Thailand; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lewis, John A.
AU - Rao, K. Murali Krishna
AU - Castranova, Vince
AU - Vallyathan, Val
AU - Dennis, William E.
AU - Knechtges, Paul L.
T1 - Proteomic Analysis of Bronchoalveolar Lavage Fluid: Effect of Acute Exposure to Diesel Exhaust Particles in Rats.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/05//
VL - 115
IS - 5
M3 - Article
SP - 756
EP - 763
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Inhalation of diesel exhaust particles (DEPs) is characterized by lung injury and inflammation, with significant increases in the numbers of polymorphonuclear leukocytes and alveolar macrophages. This influx of cellular infiltrates is associated with the activation of multiple genes, including cytokines and chemokines, and the production of reactive oxygen species. OBJECTIVE: The pathogenesis of the lung injury is not fully understood, but alterations in the presence or abundance of a number of proteins in the lung have been observed. Our objective in this study was to further characterize these changes and to ask whether additional changes could be discerned using modern proteomic techniques. METHODS: The present study investigates global alterations in the proteome of bronchoalveolar lavage fluid taken from rats 1, 7, or 30 days after exposure to 5, 35, or 50 mg/kg of animal weight of DEPs. RESULTS: Analysis by surface-enhanced laser desorption/ionization--time of flight mass spectrometry identified two distinct peaks that appeared as an acute response postexposure at all doses in all animals. We identified these two peaks, with mass to charge ratios (m/z) of 9,100 and 10,100, as anaphylatoxin C3a and calgranulin A by additional mass spectral investigation using liquid chromatography coupled to mass spectrometry. CONCLUSIONS: With this approach, we found a number of inflammatory response proteins that may be associated with the early phases of inflammation in response to DEP exposure. Further studies are warranted to determine whether serum levels of these proteins could be markers of diesel exhaust exposure in workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Chemical biology
KW - Diesel motor exhaust gas
KW - Bronchoalveolar lavage
KW - Lung diseases -- Diagnosis
KW - Inflammation -- Mediators
KW - Acute phase proteins
KW - Rats as laboratory animals
KW - calprotectin
KW - diesel
KW - inflammation
KW - macrophage
KW - mass spectrometry
KW - proteomics
KW - SELDI
N1 - Accession Number: 25744090; Lewis, John A. 1; Email Address: john.a.lewis1@us.army.mil; Rao, K. Murali Krishna 2; Castranova, Vince 2; Vallyathan, Val 2; Dennis, William E. 1; Knechtges, Paul L. 1; Affiliations: 1: U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA; 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: May2007, Vol. 115 Issue 5, p756; Thesaurus Term: RESEARCH; Thesaurus Term: Chemical biology; Subject Term: Diesel motor exhaust gas; Subject Term: Bronchoalveolar lavage; Subject Term: Lung diseases -- Diagnosis; Subject Term: Inflammation -- Mediators; Subject Term: Acute phase proteins; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: calprotectin; Author-Supplied Keyword: diesel; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: macrophage; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: proteomics; Author-Supplied Keyword: SELDI; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Calvert, Geoffrey M.
AU - Alarcon, Walter A.
AU - Chelminski, Ann
AU - Crowley, Mark S.
AU - Barrett, Rosanna
AU - Correa, Adolfo
AU - Higgins, Sheila
AU - Leon, Hugo L.
AU - Correia, Jane
AU - Becker, Alan
AU - Allen, Ruth H.
AU - Evans, Elizabeth
T1 - Case Report: Three Farmworkers Who Gave Birth to Infants with Birth Defects Closely Grouped in Time and Place--Florida and North Carolina, 2004-2005.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/05//
VL - 115
IS - 5
M3 - Article
SP - 787
EP - 791
PB - Superintendent of Documents
SN - 00916765
AB - CONTEXT: There is little evidence linking adverse reproductive effects to exposure to specific pesticides during pregnancy. CASE PRESENTATION: In February 2005, three infants with congenital anomalies were identified in Collier County, Florida, who were born within 8 weeks of one another and whose mothers worked for the same tomato grower. The mothers worked on the grower's Florida farms in 2004 before transferring to its North Carolina farms. All three worked during the period of organogenesis in fields recently treated with several pesticides. The Florida and North Carolina farms were inspected by regulatory agencies, and in each state a large number of violations were identified and record fines were levied. DISCUSSION: Despite the suggestive evidence, a causal link could not be established between pesticide exposures and the birth defects in the three infants. Nonetheless, the prenatal pesticide exposures experienced by the mothers of the three infants is cause for concern. Farmworkers need greater protections against pesticides. These include increased efforts to publicize and comply with both the U.S. Environmental Protections Agency's Worker Protection Standard and pesticide label requirements, enhanced procedures to ensure pesticide applicator competency, and recommendations to growers to adopt work practices to reduce pesticide exposures. RELEVANCE TO PROFESSIONAL PRACTICE: The findings from this report reinforce the need to reduce pesticide exposures among farmworkers. In addition, they support the need for epidemiologic studies to examine the role of pesticide exposure in the etiology of congenital anomalies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental health research
KW - Human abnormalities
KW - HEALTH
KW - Fungicides -- Environmental aspects
KW - Insecticides
KW - Diseases -- Causes & theories of causation
KW - Agricultural laborers
KW - Pregnant women
KW - United States
KW - congenital abnormalities
KW - ectromelia
KW - farmworkers
KW - fungicides
KW - Goldenhar Syndrome
KW - insecticides
KW - micrognathism
KW - pesticides
KW - prevention and control
KW - toxicity
N1 - Accession Number: 25744083; Calvert, Geoffrey M. 1; Email Address: jac6@CDC.GOV; Alarcon, Walter A. 1; Chelminski, Ann 2; Crowley, Mark S. 3; Barrett, Rosanna 4; Correa, Adolfo 5; Higgins, Sheila 2; Leon, Hugo L. 3; Correia, Jane 4; Becker, Alan 4; Allen, Ruth H. 6; Evans, Elizabeth 6; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA; 2: North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA; 3: Collier County Health Department, Naples, Florida, USA; 4: Florida Department of Health, Tallahassee, Florida, USA; 5: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 6: Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC, USA; Issue Info: May2007, Vol. 115 Issue 5, p787; Thesaurus Term: Environmental health research; Thesaurus Term: Human abnormalities; Thesaurus Term: HEALTH; Thesaurus Term: Fungicides -- Environmental aspects; Thesaurus Term: Insecticides; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Agricultural laborers; Subject Term: Pregnant women; Subject: United States; Author-Supplied Keyword: congenital abnormalities; Author-Supplied Keyword: ectromelia; Author-Supplied Keyword: farmworkers; Author-Supplied Keyword: fungicides; Author-Supplied Keyword: Goldenhar Syndrome; Author-Supplied Keyword: insecticides; Author-Supplied Keyword: micrognathism; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: prevention and control; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105827822
T1 - Case report: three frameworkers who gave birth to infants with birth defects closely grouped in time and place -- Florida and North Carolina, 2004-2005.
AU - Calvert GM
AU - Alarcon WA
AU - Chelminski A
AU - Crowley MS
AU - Barrett R
AU - Correa A
AU - Higgins S
AU - Leon HL
AU - Correia J
AU - Becker A
AU - Allen RH
AU - Evans E
Y1 - 2007/05//
N1 - Accession Number: 105827822. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 0330411.
KW - Abnormalities -- Etiology
KW - Agriculture -- Legislation and Jurisprudence
KW - Occupational Exposure -- Adverse Effects
KW - Pesticides
KW - Agriculture -- Methods
KW - Cluster Analysis
KW - Female
KW - Florida
KW - Infant, Newborn
KW - Male
KW - North Carolina
KW - Human
SP - 787
EP - 791
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 115
IS - 5
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - CONTEXT: There is little evidence linking adverse reproductive effects to exposure to specific pesticides during pregnancy. CASE PRESENTATION: In February 2005, three infants with congenital anomalies were identified in Collier County, Florida, who were born within 8 weeks of one another and whose mothers worked for the same tomato grower. The mothers worked on the grower's Florida farms in 2004 before transferring to its North Carolina farms. All three worked during the period of organogenesis in fields recently treated with several pesticides. The Florida and North Carolina farms were inspected by regulatory agencies, and in each state a large number of violations were identified and record fines were levied. DISCUSSION: Despite the suggestive evidence, a causal link could not be established between pesticide exposures and the birth defects in the three infants. Nonetheless, the prenatal pesticide exposures experienced by the mothers of the three infants is cause for concern. Farmworkers need greater protections against pesticides. These include increased efforts to publicize and comply with both the U.S. Environmental Protections Agency's Worker Protection Standard and pesticide label requirements, enhanced procedures to ensure pesticide applicator competency, and recommendations to growers to adopt work practices to reduce pesticide exposures. RELEVANCE TO PROFESSIONAL PRACTICE: The findings from this report reinforce the need to reduce pesticide exposures among farmworkers. In addition, they support the need for epidemiologic studies to examine the role of pesticide exposure in the etiology of congenital anomalies.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati , OH 45226 USA
U2 - PMID: 17520069.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - H. C. VAN WOERDEN
AU - M. R. EVANS
AU - B. W. MASON
AU - L. NEHAUL
T1 - Using facsimile cascade to assist case searching during a Q fever outbreak.
JO - Epidemiology & Infection
JF - Epidemiology & Infection
Y1 - 2007/05//
VL - 135
IS - 5
M3 - Article
SP - 798
EP - 801
SN - 09502688
AB - In September 2002, facsimiles were sent to 360 primary-care physicians alerting them to a local outbreak of Q fever. The physicians subsequently submitted serology samples on significantly more patients than in a previously comparable period in 2001. Facsimile cascade assists effective communication with primary-care physicians in an outbreak investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Epidemiology & Infection is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Public health
KW - Q fever
KW - Fax transmission
KW - Fax machines
KW - Primary care (Medicine)
KW - Diagnostic microbiology
N1 - Accession Number: 25726710; H. C. VAN WOERDEN 1; M. R. EVANS 1; B. W. MASON 2; L. NEHAUL 3; Affiliations: 1: Cardiff University, Cardiff, UK; 2: National Public Health Service for Wales, Cardiff, UK; 3: National Public Health Service for Wales, Pontypool, UK; Issue Info: May2007, Vol. 135 Issue 5, p798; Thesaurus Term: Epidemics; Thesaurus Term: Public health; Subject Term: Q fever; Subject Term: Fax transmission; Subject Term: Fax machines; Subject Term: Primary care (Medicine); Subject Term: Diagnostic microbiology; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 334210 Telephone Apparatus Manufacturing; NAICS/Industry Codes: 417910 Office and store machinery and equipment merchant wholesalers; NAICS/Industry Codes: 532420 Office Machinery and Equipment Rental and Leasing; NAICS/Industry Codes: 811213 Communication Equipment Repair and Maintenance; NAICS/Industry Codes: 423690 Other Electronic Parts and Equipment Merchant Wholesalers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - T. M. A. FERNANDES
AU - C. SCHOUT
AU - A. M. De RODA HUSMAN
AU - A. EILANDER
AU - H. VENNEMA
AU - Y. T. H. P. van DUYNHOVEN
T1 - Gastroenteritis associated with accidental contamination of drinking water with partially treated water.
JO - Epidemiology & Infection
JF - Epidemiology & Infection
Y1 - 2007/05//
VL - 135
IS - 5
M3 - Article
SP - 818
EP - 826
SN - 09502688
AB - Due to human error, drinking water supplied to a new housing estate in The Netherlands was contaminated with grey water. The cohort of 921 accidentally exposed households (area A) had a higher attack rate for diarrhoea (54·1%) than a non-exposed cohort of 1529 households from an adjacent area (B) (24%) (RR 2·3, 95% CI 1·9–2·7). Household water score showed a dose-response with illness, in both areas A and B. For each 1000 inhabitants, 19·8 cases in area A, 7·0 cases in control area B (RRAB 2·2, 95% CI 1·3–3·8) and 3·3 cases in a more distant control area C (RRAC 4·6, 95% CI 2·7–8·0) were diagnosed with gastroenteritis by their general practitioner. A gastroenteritis outbreak associated with consumption of contaminated drinking water was observed in the exposed area. The use of grey water was banned in 2003, with the exception of rainwater use for flushing toilets. The risk of rainwater use is currently being investigated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Epidemiology & Infection is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Contamination of drinking water
KW - Epidemics
KW - Public health
KW - Gastroenteritis
KW - Diarrhea
KW - Netherlands
N1 - Accession Number: 25726722; T. M. A. FERNANDES 1; C. SCHOUT 2; A. M. De RODA HUSMAN 3; A. EILANDER 2; H. VENNEMA 4; Y. T. H. P. van DUYNHOVEN 5; Affiliations: 1: European Programme for Intervention Epidemiology Training (EPIET), National Institute for Public Health and the Environment (RIVM), The Netherlands; 2: Public Health Service, Utrecht, The Netherlands; 3: Microbiological Laboratory for Health Protection, RIVM, The Netherlands; 4: Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, RIVM, The Netherlands; 5: Department for Infectious Diseases Epidemiology, RIVM, The Netherlands; Issue Info: May2007, Vol. 135 Issue 5, p818; Thesaurus Term: Contamination of drinking water; Thesaurus Term: Epidemics; Thesaurus Term: Public health; Subject Term: Gastroenteritis; Subject Term: Diarrhea; Subject: Netherlands; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jun, Hye-Seung
AU - Park, Taesun
AU - Lee, Chang Ki
AU - Kang, Mi Kyung
AU - Park, Mi Sun
AU - Kang, Ho Il
AU - Surh, Young-Joon
AU - Kim, Ok Hee
T1 - Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2007/05//
VL - 45
IS - 5
M3 - Article
SP - 708
EP - 715
SN - 02786915
AB - Abstract: Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili peppers, has been reported to possess substantial anticarcinogenic and antimutagenic activities. In the present study, we investigated the effect of capsaicin on induction of apoptosis in highly metastatic B16-F10 murine melanoma cells. Capsaicin inhibited growth of B16-F10 cells in a concentration-dependent manner. Proapoptotic effect of capsaicin was evidenced by nuclear condensation, internucleosomal DNA fragmentation, in situ terminal nick-end labeling of fragmented DNA (TUNEL), and an increased sub G1 fraction. Treatment of B16-F10 cells with capsaicin caused release of mitochondrial cytochrome c, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner. Furthermore, Bcl-2 expression in the B16-F10 cells was slightly down-regulated by capsaicin treatment. In contrast, there were no alterations in the levels of Bax in capsaicin-treated cells. Collectively, these findings indicate that capsaicin-induces apoptosis of B16-F10 melanoma cells via down-regulation the Bcl-2. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAPSAICIN
KW - APOPTOSIS
KW - CELLS
KW - THERAPEUTICS
KW - MELANOMA
KW - Apoptosis
KW - B16-F10 melanoma cells
KW - Bcl-2
KW - Capsaicin
KW - DNA fragmentation
KW - Flow cytometry
N1 - Accession Number: 24461841; Jun, Hye-Seung 1,2 Park, Taesun 2 Lee, Chang Ki 1 Kang, Mi Kyung 1 Park, Mi Sun 1 Kang, Ho Il 1 Surh, Young-Joon 3 Kim, Ok Hee 1; Email Address: kimkfda@kfda.go.kr; Affiliation: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyong-Gu, Seoul 122-704, Republic of Korea 2: Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, 134 Sinchon-Dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea 3: College of Pharmacy, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Republic of Korea; Source Info: May2007, Vol. 45 Issue 5, p708; Subject Term: CAPSAICIN; Subject Term: APOPTOSIS; Subject Term: CELLS; Subject Term: THERAPEUTICS; Subject Term: MELANOMA; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: B16-F10 melanoma cells; Author-Supplied Keyword: Bcl-2; Author-Supplied Keyword: Capsaicin; Author-Supplied Keyword: DNA fragmentation; Author-Supplied Keyword: Flow cytometry; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2006.10.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doull, John
AU - Borzelleca, Joseph F.
AU - Becker, Richard
AU - Daston, George
AU - DeSesso, John
AU - Fan, Anna
AU - Fenner-Crisp, Penelope
AU - Holsapple, Michael
AU - Holson, Joseph
AU - Craig Llewellyn, G.
AU - MacGregor, James
AU - Seed, Jennifer
AU - Walls, Isabel
AU - Woo, Yin-tak
AU - Olin, Stephen
T1 - Framework for use of toxicity screening tools in context-based decision-making
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2007/05//
VL - 45
IS - 5
M3 - Article
SP - 759
EP - 796
SN - 02786915
AB - Abstract: One of the principal applications of toxicology data is to inform risk assessments and support risk management decisions that are protective of human health. Ideally, a risk assessor would have available all of the relevant information on (a) the toxicity profile of the agent of interest; (b) its interactions with living systems; and (c) the known or projected exposure scenarios: to whom, how much, by which route(s), and how often. In practice, however, complete information is seldom available. Nonetheless, decisions still must be made. Screening-level assays and tools can provide support for many aspects of the risk assessment process, as long as the limitations of the tools are understood and to the extent that the added uncertainty the tools introduce into the process can be characterized and managed. Use of these tools for decision-making may be an end in itself for risk assessment and decision-making or a preliminary step to more extensive data collection and evaluation before assessments are undertaken or completed and risk management decisions made. This paper describes a framework for the application of screening tools for human health decision-making, although with some modest modification, it could be made applicable to environmental settings as well. The framework consists of problem formulation, development of a screening strategy based on an assessment of critical data needs, and a data analysis phase that employs weight-of-evidence criteria and uncertainty analyses, and leads to context-based decisions. Criteria for determining the appropriate screening tool(s) have been identified. The choice and use of the tool(s) will depend on the question and the level of uncertainty that may be appropriate for the context in which the decision is being made. The framework is iterative, in that users may refine the question(s) as they proceed. Several case studies illustrate how the framework may be used effectively to address specific questions for any endpoint of toxicity. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - RISK management in business
KW - HEALTH
KW - RISK assessment
KW - DECISION making
KW - DATA analysis
KW - Carcinogenicity
KW - Decision tree
KW - Endocrine disruptor
KW - Immunotoxicity
KW - Structure–activity relationships
KW - Toxicity testing
N1 - Accession Number: 24461846; Doull, John 1 Borzelleca, Joseph F. 2 Becker, Richard 3 Daston, George 4 DeSesso, John 5 Fan, Anna 6 Fenner-Crisp, Penelope 7 Holsapple, Michael 8 Holson, Joseph 9 Craig Llewellyn, G. 10 MacGregor, James 11 Seed, Jennifer 12 Walls, Isabel 7 Woo, Yin-tak 12 Olin, Stephen 7; Email Address: solin@ilsi.org; Affiliation: 1: University of Kansas, United States 2: Virginia Commonwealth University, United States 3: American Chemistry Council, United States 4: The Procter & Gamble Company, United States 5: Mitretek Systems, United States 6: California Environmental Protection Agency, United States 7: ILSI Research Foundation, Risk Science Institute, One Thomas Circle, NW, Suite 900, Washington, DC 20005, United States 8: ILSI Health and Environmental Sciences Institute, United States 9: WIL Research Laboratories, United States 10: Kraft Foods, United States 11: US Food and Drug Administration, United States 12: US Environmental Protection Agency, United States; Source Info: May2007, Vol. 45 Issue 5, p759; Subject Term: TOXICOLOGY; Subject Term: RISK management in business; Subject Term: HEALTH; Subject Term: RISK assessment; Subject Term: DECISION making; Subject Term: DATA analysis; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Decision tree; Author-Supplied Keyword: Endocrine disruptor; Author-Supplied Keyword: Immunotoxicity; Author-Supplied Keyword: Structure–activity relationships; Author-Supplied Keyword: Toxicity testing; Number of Pages: 38p; Document Type: Article
L3 - 10.1016/j.fct.2006.10.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Yan
AU - Kim, Mi Ra
AU - Lee, Kang Bong
AU - Kim, In Seon
AU - Shim, Jae Han
T1 - Determination of procymidone residues in ginseng by GC–ECD and GC–MS equipped with a solvent-free solid injector
JO - Food Control
JF - Food Control
Y1 - 2007/05//
VL - 18
IS - 4
M3 - Article
SP - 364
EP - 368
SN - 09567135
AB - Abstract: A rapid method for determination of the insecticide procymidone in ginseng was studied by gas chromatographic analysis equipped with a solvent-free solid injector, Keele injector. Ginseng samples were freeze-dried, weighed carefully in milligram quantities and introduced into a glass tube in a Keele injector at a gas chromatograph injection port. The glass tube was then crushed to allow the sample to directly carry onto a capillary column in a normal manner. The recoveries of procymidone by the Keele injector method were close to those by a traditional method using a syringe, giving the recovery values ranging from 86% to 92% at the tested concentrations of 0.1 and 1.0mg/kg. The Keele injector method was examined to detect procymidone in ginsengs obtained from agricultural markets. When 27 ginseng samples were analyzed by GC–MS and GC–ECD equipped with the Keele injector method, 14 samples of them contained procymidone in concentrations ranging from 0.2 to 0.8mg/kg, which was the same results by the traditional method. Using the Keele injector method could skip sample preparation steps required generally in the traditional method. The data suggest that the Keele injector can be used as a sample introduction device for GC–ECD or GC–MS analysis of procymidone residues in ginsengs. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINSENG
KW - CRYOBIOLOGY
KW - PHASE partition
KW - ANALYTICAL chemistry
KW - Ginseng
KW - Pesticide
KW - Procymidone
KW - Solvent-free solid injector
N1 - Accession Number: 22581885; Li, Yan 1 Kim, Mi Ra 1 Lee, Kang Bong 2 Kim, In Seon 1 Shim, Jae Han 1; Email Address: jhshim@chonnam.ac.kr; Affiliation: 1: Division of Applied Bioscience and Biotechnology, Institute of Agricultural Science and Technology, College of Agriculture and Life Science, Chonnam National University, Gwangju 500-757, South Korea 2: Division of Food Standard, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: May2007, Vol. 18 Issue 4, p364; Subject Term: GINSENG; Subject Term: CRYOBIOLOGY; Subject Term: PHASE partition; Subject Term: ANALYTICAL chemistry; Author-Supplied Keyword: Ginseng; Author-Supplied Keyword: Pesticide; Author-Supplied Keyword: Procymidone; Author-Supplied Keyword: Solvent-free solid injector; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodcont.2005.11.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yoon, Eunkyung
AU - Park, Kyungah
AU - Lee, Hyomin
AU - Yang, Jae-Ho
AU - Lee, Cherlho
T1 - Estimation of Excess Cancer Risk on Time-Weighted Lifetime Average Daily Intake of PAHs from Food Ingestion.
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2007/05//May/Jun2007
VL - 13
IS - 3
M3 - Article
SP - 669
EP - 680
SN - 10807039
AB - The purposes of this study were to quantify the time-weighted, lifetime average, daily intake (LADI) of polycyclic aromatic hydrocarbons (PAHs) through food ingestion and to estimate the excess cancer risk based on lifetime dietary PAH intake. Twenty-seven different food commodities were selected from the 2001 Korean National Health and Nutrition survey based on their frequent consumption and high PAH level. The foods were analyzed for the profile of 14 PAH congeners using high performance liquid chromatography (HPLC) and fluorescence detector. Considering the toxic equivalent (TEQ) level converted with the toxic equivalent factors (TEFs), the highest total TEQ level of PAHs in foods was detected from roasted laver at 1.2 ug TEQ/kg. For the PAH exposure assessment according to ingested foods, the average body weight was separated according to the following age groups, 1-6, 7-19, 20-64 and over 64 years, and the daily food ingestion rates from the National Health and Nutrition survey were used. The estimated Lifetime Average Daily Intake (LADI) of PAHs was 3.22 × 10-3 ug/kg/day for carcinogenic effects and was higher in the younger age groups under 20 years old than in the older groups. The dietary excess cancer risk estimated using the cancer potency of benzo(a)pyrene (7.3(mg/kg/day)-1) was 2.3 × 10-5, which is equivalent to a probability of tumor eruption in the upper gastrointestinal tract of two per hundred thousand persons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Ecological Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromatographic analysis
KW - Liquid chromatography
KW - Cancer -- Nutritional aspects
KW - Polycyclic aromatic hydrocarbons -- Physiological effect
KW - Cancer research
KW - Nutritionally induced diseases
KW - Diet in disease
KW - excess cancer risk
KW - lifetime average daily intake(LADI)
KW - polycyclic aromatic hydrocarbons (PAHs)
KW - toxic equivalent factors (TEFs)
N1 - Accession Number: 25084903; Yoon, Eunkyung 1; Park, Kyungah 1; Lee, Hyomin 1; Yang, Jae-Ho 2; Lee, Cherlho 3; Affiliations: 1: Department of Risk Assessment Research, Korea Food and Drug Administration. Eunpyung-ku, Seoul. Republic of Korea; 2: College of Medicine, Catholic University of Taegu. Taegu. Republic of Korea; 3: Graduate School of Biotechnology, Korea University. Sungbuk-ku, Seoul. Republic of Korea; Issue Info: May/Jun2007, Vol. 13 Issue 3, p669; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Liquid chromatography; Subject Term: Cancer -- Nutritional aspects; Subject Term: Polycyclic aromatic hydrocarbons -- Physiological effect; Subject Term: Cancer research; Subject Term: Nutritionally induced diseases; Subject Term: Diet in disease; Author-Supplied Keyword: excess cancer risk; Author-Supplied Keyword: lifetime average daily intake(LADI); Author-Supplied Keyword: polycyclic aromatic hydrocarbons (PAHs); Author-Supplied Keyword: toxic equivalent factors (TEFs); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
L3 - 10.1080/10807030701226871
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gammell, Paul M.
AU - Maruvada, Subha
AU - Harris, Gerald R.
T1 - An Ultrasonic Time-Delay Spectrometry System Employing Digital Processing.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2007/05//
VL - 54
IS - 5
M3 - Article
SP - 1036
EP - 1044
SN - 08853010
AB - Time-delay spectrometry (TDS) is a swept- frequency technique that has proven useful in several ultrasonic applications. Commercial TDS systems are available, but only in the audio frequency range. Several ultrasonic research TDS systems have been constructed, and they have been used effectively for substitution calibration of hydrophones and for measurement of attenuation and sound velocity in materials. Unfortunately these systems depend on features of commercial equipment no longer manufactured, so a new system has been designed using modern equipment and straightforward signal processing. This system requires a frequency source with a reasonably linear sweep of frequency versus time, audio frequency filters, a standard double-balanced mixer, a power splitter, a wave- form digitizer capable of handling audio frequency signals, and a personal computer. An optional implementation that shifts the signal to a lower frequency for more convenient digitization and easier velocity measurements additionally requires an audio frequency oscillator and an audio-range analog multiplier. The processing steps are performed with standard signal processing software. To demonstrate the operation of the system, substitution calibration measurements of hydrophones as well as attenuation measurements on a tissue mimicking material were obtained and compared to a custom TDS system previously described by the authors. The data from these two TDS systems agree to within ±0.5 dB in the 1-10 MHz frequency range used. Higher frequency source transducers could be used to extend this range. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TIME delay systems
KW - SPECTROMETRY
KW - DIGITAL electronics
KW - LABORATORY techniques
KW - HYDROPHONE
N1 - Accession Number: 25100378; Gammell, Paul M. 1; Email Address: pgammell@ieee.org Maruvada, Subha 2 Harris, Gerald R. 2; Affiliation: 1: Gammell Applied Technologies, LLC, Ex- more, VA 23350 2: Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993.; Source Info: May2007, Vol. 54 Issue 5, p1036; Subject Term: TIME delay systems; Subject Term: SPECTROMETRY; Subject Term: DIGITAL electronics; Subject Term: LABORATORY techniques; Subject Term: HYDROPHONE; Number of Pages: 9p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1109/TUFFC. 2007. 349
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blachere, Francoise M.
AU - Lindsley, William G.
AU - Slaven, James E.
AU - Green, Brett J.
AU - Anderson, Stacey E.
AU - Chen, Bean T.
AU - Beezhold, Don H.
T1 - Bioaerosol sampling for the detection of aerosolized influenza virus.
JO - Influenza & Other Respiratory Viruses
JF - Influenza & Other Respiratory Viruses
Y1 - 2007/05//
VL - 1
IS - 3
M3 - Article
SP - 113
EP - 120
SN - 17502640
AB - Background Influenza virus was used to characterize the efficacy of a cyclone-based, two-stage personal bioaerosol sampler for the collection and size fractionation of aerosolized viral particles. Methods A Collison single-jet nebulizer was used to aerosolize the attenuated FluMist® vaccine into a calm-air settling chamber. Viral particles were captured with bioaerosol samplers that utilize 2 microcentrifuge tubes to collect airborne particulates. The first tube (T1) collects particles greater than 1.8 μm in diameter, while the second tube (T2) collects particles between 1.0 and 1.8 μm, and the back-up filter (F) collects submicron particles. Following aerosolization, quantitative PCR was used to detect and quantify H1N1 and H3N2 influenza strains. Results Based on qPCR results, we demonstrate that aerosolized viral particles were efficiently collected and separated according to aerodynamic size using the two-stage bioaerosol sampler. Most viral particles were collected in T2 (1-1.8 μm) and on the back-up filter (< 1 μm) of the bioaerosol sampler. Furthermore, we found that the detection of viral particles with the two-stage sampler was directly proportional to the collection time. Consequently, viral particle counts were significantly greater at 40 minutes in comparison to 5, 10 and 20 minute aerosol collection points. Conclusions Due to a lack of empirical data, aerosol transmission of influenza is often questioned. Using FluMist®, we demonstrated that a newly developed bioaerosol sampler is able to recover and size fractionate aerosolized viral particles. This sampler should be an important tool for studying viral transmission in clinical settings and may significantly contribute towards understanding the modes of influenza virus transmission. [ABSTRACT FROM AUTHOR]
AB - Copyright of Influenza & Other Respiratory Viruses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - INFLUENZA viruses
KW - VACCINES
KW - VIRUS diseases
KW - WATER quality -- Measurement
KW - Airborne virus
KW - bioaerosol sampler
KW - bioaerosols
KW - influenza
KW - qPCR
KW - viral detection
N1 - Accession Number: 26771186; Blachere, Francoise M. 1 Lindsley, William G. 2 Slaven, James E. 3 Green, Brett J. 1 Anderson, Stacey E. 1 Chen, Bean T. 2 Beezhold, Don H. 1; Affiliation: 1: Centers for Disease Control, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, Morgantown, WV, USA 2: Centers for Disease Control, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, WV, USA 3: Centers for Disease Control, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, Morgantown, WV, USA; Source Info: May2007, Vol. 1 Issue 3, p113; Subject Term: AEROSOLS (Sprays); Subject Term: INFLUENZA viruses; Subject Term: VACCINES; Subject Term: VIRUS diseases; Subject Term: WATER quality -- Measurement; Author-Supplied Keyword: Airborne virus; Author-Supplied Keyword: bioaerosol sampler; Author-Supplied Keyword: bioaerosols; Author-Supplied Keyword: influenza; Author-Supplied Keyword: qPCR; Author-Supplied Keyword: viral detection; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1750-2659.2007.00020.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106119803
T1 - Flu 101.
AU - Brennon C III
Y1 - 2007/05//2007 May
N1 - Accession Number: 106119803. Language: English. Entry Date: 20070720. Revision Date: 20150820. Publication Type: Journal Article; brief item; pictorial. Journal Subset: Allied Health; Editorial Board Reviewed; Peer Reviewed; USA. Special Interest: Emergency Care. NLM UID: 8102138.
KW - Disease Outbreaks
KW - Influenza -- Epidemiology
KW - Orthomyxoviridae
KW - Influenza Vaccine
KW - Influenza, Avian
KW - United States
SP - 48
EP - 48
JO - JEMS: Journal of Emergency Medical Services
JF - JEMS: Journal of Emergency Medical Services
JA - JEMS
VL - 32
IS - 5
CY - ,
PB - Elsevier Public Safety
SN - 0197-2510
AD - Director of EMS and Public Health Preparedness Coordinator, Jefferson County Public Health Service, Watertown, NY; cbrenon3@verizon.net
U2 - PMID: 17523261.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MARKS, HEIDI S.
T1 - Rapid Gas Chromatography/Mass Spectrometry Determination and Confirmation of Patulin in Apple Juice.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/05//May/Jun2007
VL - 90
IS - 3
M3 - Article
SP - 879
EP - 883
PB - AOAC International
SN - 10603271
AB - The article describes a gas chromatography/mass spectrometry (GC/MS) method developed for the quantitative determination and confirmation of patulin extracted from apple juice. Patulin content was determined using an electron-impact source and selected ion monitoring of characteristic ions. The limits of quantitation and detection were 10 and three microgram per liter, respectively.
KW - GAS chromatography
KW - MASS spectrometry
KW - GAS chromatography/Mass spectrometry (GC-MS)
KW - APPLE juice
KW - TECHNICAL chemistry
N1 - Accession Number: 25635202; MARKS, HEIDI S. 1; Email Address: heidi.marks@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021; Source Info: May/Jun2007, Vol. 90 Issue 3, p879; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: GAS chromatography/Mass spectrometry (GC-MS); Subject Term: APPLE juice; Subject Term: TECHNICAL chemistry; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slikker, Jr., William
AU - Paule, Merle G.
AU - Wright, Linnzi K. M.
AU - Patterson, Tucker A.
AU - Cheng Wang
T1 - Systems biology approaches for toxicology.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2007/05//May/Jun2007
VL - 27
IS - 3
M3 - Article
SP - 201
EP - 217
SN - 0260437X
AB - The article discusses the study on the value of systems biology in enhancing the perceptives on the complex biological processes in the developing brain in the U.S. It notes that systems biology was identified as an iterative and integrative study of biological systems as it to perturbations. Moreover, molecular biology approaches including genomics, proteomics and metabolomics are essential in providing data which are necessary for the building blocks of the systems biology. In addition, the data base will also provide the intermediate components necessary for the systems approach. Further, the goal of the systems biology is to predict the functional outcomes of component to component relationships using computational models that allows description of the complete organism.
KW - Toxicology
KW - RESEARCH
KW - Biological systems
KW - Molecular biology
KW - Biochemistry
KW - Brain
KW - Biology -- Study & teaching
KW - Genomics
KW - Proteomics
KW - United States
KW - anesthetic agents
KW - Arraylrack
KW - development
KW - DNA repair
KW - gene expression
KW - neurodegeneration
KW - NMDA receptor antagonist
N1 - Accession Number: 27590820; Slikker, Jr., William 1; Email Address: william.slikker@fda.hhs.gov; Paule, Merle G. 1; Wright, Linnzi K. M. 1; Patterson, Tucker A. 1; Cheng Wang 1; Affiliations: 1: National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas, USA; Issue Info: May/Jun2007, Vol. 27 Issue 3, p201; Thesaurus Term: Toxicology; Thesaurus Term: RESEARCH; Thesaurus Term: Biological systems; Thesaurus Term: Molecular biology; Subject Term: Biochemistry; Subject Term: Brain; Subject Term: Biology -- Study & teaching; Subject Term: Genomics; Subject Term: Proteomics; Subject: United States; Author-Supplied Keyword: anesthetic agents; Author-Supplied Keyword: Arraylrack; Author-Supplied Keyword: development; Author-Supplied Keyword: DNA repair; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: NMDA receptor antagonist; Number of Pages: 17p; Document Type: Article
L3 - 10.1002/jal.1207
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kunkle, Carey A.
AU - Schmitt, Michael P.
T1 - Comparative Analysis of hmuO Function and Expression in Corynebacterium Species.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2007/05//
VL - 189
IS - 9
M3 - Article
SP - 28
EP - 28
SN - 00219193
AB - We have constructed defined deletions in the hmuO gene from Corynebacterium diphtheriae and Corynebacterium ulcerans and show that the C. ulcerans hmuO mutation results in a significant reduction in hemoglobin-iron utilization, whereas in C. diphtheriae strains, deletion of hmuO caused no or only partial reduction in the utilization of heme as an iron source. We also show that expression from the C. ulcerans hmuO promoter exhibits minimal regulation by iron and heme whereas transcription from the C. diphtheriae hmuO promoter shows both significant iron repression and heme-dependent activation. These findings indicate that variability in HmuO function and expression exists among Corynebacterium species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CORYNEBACTERIUM
KW - HEMOGLOBIN
KW - HEME
KW - IRON
KW - BACTERIAL genetics
KW - CORYNEBACTERIUM diphtheriae
N1 - Accession Number: 24822001; Kunkle, Carey A. 1 Schmitt, Michael P. 1; Email Address: michael.schmitt@fda.hhs.gov; Affiliation: 1: Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: May2007, Vol. 189 Issue 9, p28; Subject Term: CORYNEBACTERIUM; Subject Term: HEMOGLOBIN; Subject Term: HEME; Subject Term: IRON; Subject Term: BACTERIAL genetics; Subject Term: CORYNEBACTERIUM diphtheriae; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.00056-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perfield II, J. W.
AU - Lock, A. L.
AU - Griinari, J. M.
AU - Saæbø, A.
AU - Delmonte, P.
AU - Dwyer, D. A.
AU - Bauman, D. E.
T1 - Trans-9, Cis-11 Conjugated Linoleic Acid Reduces Milk Fat Synthesis in Lactating Dairy Cows.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2007/05//
VL - 90
IS - 5
M3 - Article
SP - 2211
EP - 2218
SN - 00220302
AB - Under certain dietary situations, rumen biohydrogenation results in the production of unique fatty acids that inhibit milk fat synthesis. The first of these to be identified was trans-10, cis-12 conjugated linoleic acid (CLA), but others are postulated to contribute to diet-induced milk fat depression (MFD). Our objective was to examine the potential role of trans-9, cis-11 CLA in the regulation of milk fat. In a preliminary study, we used gas-liquid and high-performance liquid chromatography techniques to examine milk fat samples from a diet-induced MFD study and found that an increase in trans-9, cis-11 CLA corresponded to the decrease in milk fat yield. We investigated this further using a CLA enrichment of 9, 11 isomers to examine the biological effect of trans-9, cis-11 CLA on milk fat synthesis. Four rumen-fistulated Holstein cows were randomly assigned in a 4 x 4 Latin square experiment involving 5-d treatment periods and abomasal infusion of 1) ethanol (control), 2) a 9, 11 CLA mix (containing 32% trans-9, cis-11, 29% cis-9, trans-11, and 17% trans-9, trans-11), 3) a trans-9, trans-11 CLA supplement, and 4) a trans-10, cis-12 CLA supplement (positive control). The trans-9, trans-11 CLA and trans-10, cis-12 CLA supplements were of high purity (>90%), and all supplements were infused at a rate to provide 5 g/d of the CLA isomer of interest. Milk yield and dry matter intake did not differ among treatments. Compared with the control treatment, milk fat yield was reduced by 15% for the 9, 11 CLA mixture and by 27% for the trans-10, cis-12 CLA treatment. We also found that trans-9, trans-11 CLA had no effect on milk fat yield, and previous research has shown that milk fat yield is unaltered when cows are infused with cis-9, trans-11 CLA. When all treatments were considered, results suggested that trans-9, cis-11 was the CLA isomer in the 9, 11 CLA mix responsible for the reduction in milk fat synthesis, although the magnitude was less than that observed for trans-10, cis-12 CLA. Interestingly, trans-9, trans-11 CLA altered the milk fat desaturase index, further demonstrating that alterations in desaturase can occur independently of effects on milk fat synthesis. Overall, our investigations identified that an increase in milk fat content of trans-9, cis-11 CLA was associated with diet-induced MFD and provided evidence of a role for this isomer in MFD based on the 15% reduction in milk fat yield with abomasal infusion of a CLA enrichment that supplied 5 g/d of trans-9, cis-11 CLA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dairy Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cows
KW - Linoleic acid
KW - Milkfat
KW - Lactation
KW - Milk yield
KW - conjugated linoleic acid
KW - cow
KW - lactation
KW - milk fat depression
N1 - Accession Number: 24959123; Perfield II, J. W. 1; Lock, A. L. 2; Griinari, J. M. 3; Saæbø, A. 2; Delmonte, P. 4; Dwyer, D. A. 1; Bauman, D. E. 1; Email Address: deb6@cornell.edu; Affiliations: 1: Department of Animal Science, Cornell University, Ithaca, NY 14853; 2: Natural ASA, Hovdebygda, Norway; 3: University of Helsinki, Department of Animal Science, Helsinki, Finland; 4: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740; Issue Info: May2007, Vol. 90 Issue 5, p2211; Thesaurus Term: Cows; Subject Term: Linoleic acid; Subject Term: Milkfat; Subject Term: Lactation; Subject Term: Milk yield; Author-Supplied Keyword: conjugated linoleic acid; Author-Supplied Keyword: cow; Author-Supplied Keyword: lactation; Author-Supplied Keyword: milk fat depression; NAICS/Industry Codes: 112120 Dairy Cattle and Milk Production; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.3168/jds.2006-745
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Mossoba, M. M.
AU - Al-Khaldi, S. F.
AU - Curtis, S. K.
AU - Battrell, C. F.
AU - Fry, F. S.
T1 - Application of a Novel Hydrophilic Infrared-Transparent Membrane to the Differentiation between Microcolonies of Enterobacter sakazakii and Klebsiella pneumoniae.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/05//
VL - 70
IS - 5
M3 - Article
SP - 1241
EP - 1245
SN - 0362028X
AB - A proof-of-concept study is reported for the differentiation between microcolonies of Enterobacter sakazakii and Klebsiella pneumoniae by means of a novel sample preparation for infrared (IR) analysis. A disposable, IR-transparent, microporous (0.2-µm pores), hydrophobic, polyethylene (PE) membrane (51 µm thick) was plasma treated under an oxygen atmosphere and used to (i) filter (or print microarrays of) dilute aqueous foodborne bacterial suspensions and (ii) subsequently grow bacterial microcolonies when the treated, hydrophilic PE membrane was placed over brain heart infusion agar medium and incubated. Because this unique membrane is transparent to IR light, isolated microcolonies (200 µm) of bacterial cells grown on this PE substrate for the first time could be directly fingerprinted by IR microspectroscopy in the transmission mode. Hence, time-consuming bacterial cell transfer from culture plates to an IR sample holder for subsequent measurement by IR spectroscopy was eliminated. Multivariate analysis of the observed IR spectra for microcolonies allowed the rapid differentiation between E. sakazakii and K. pneumoniae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterobacteriaceae
KW - Spectrum analysis
KW - Klebsiella pneumoniae
KW - Multivariate analysis
KW - Enterobacter
KW - Bacterial cultures
N1 - Accession Number: 25100763; Mossoba, M. M. 1; Email Address: magdi.mossoba@fda.hhs.gov; Al-Khaldi, S. F. 2; Curtis, S. K. 2; Battrell, C. F. 3; Fry, F. S. 1; Affiliations: 1: Division of Analytical Chemistry, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835; 2: Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835; 3: Micronics, Inc., 8463 154th Avenue N.E., Redmond, Washington 98052, USA; Issue Info: May2007, Vol. 70 Issue 5, p1241; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Spectrum analysis; Subject Term: Klebsiella pneumoniae; Subject Term: Multivariate analysis; Subject Term: Enterobacter; Subject Term: Bacterial cultures; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
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ER -
TY - JOUR
AU - SAMUEL, MICHAEL C.
AU - VUGIA, DUC J.
AU - KOEHLER, KATHLEEN M.
AU - MARCUS, RUTHANNE
AU - DENEEN, VALERIE
AU - DAMASKE, BARBARA
AU - SHIFERAW, BELETSHACHEW
AU - HADLER, JAMES
AU - HENAO, OLGA L.
AU - ANGULO, FREDERICK J.
T1 - CONSUMPTION OF RISKY FOODS AMONG ADULTS AT HIGH RISK FOR SEVERE FOODBORNE DISEASES: ROOM FOR IMPROVED TARGETED PREVENTION MESSAGES.
JO - Journal of Food Safety
JF - Journal of Food Safety
Y1 - 2007/05//
VL - 27
IS - 2
M3 - Article
SP - 219
EP - 232
SN - 01496085
AB - Foodborne disease is of particular concern in populations at risk for severe consequences, including the elderly and persons with immune-compromising conditions. Using data from the Foodborne Diseases Active Surveillance Network (FoodNet) Population Survey, we examined the association of risky food consumption with gender, age, immune status, income and education. Gender, age and immune status were associated with consumption of risky foods. More males than females ate at least one risky food while persons aged ≥ 65 years were less likely than those 18–44 to eat risky foods. In the 18–44 group, those with immunosuppressive conditions were more likely to eat risky foods (P < 0.001). In the ≥ 65 group, those taking immunosuppressive drugs were more likely than healthy persons to eat risky foods (P < 0.001). Our findings suggest that young adults with immune-compromising conditions and elderly persons who take immunosuppressive drugs report eating more risky foods than their healthy counterparts. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Safety is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOODBORNE diseases
KW - RESEARCH
KW - FOOD consumption -- Research
KW - OLDER people -- Health
KW - IMMUNOSUPPRESSIVE agents
KW - YOUNG adults -- Diseases
KW - FOOD -- Safety measures
KW - PREVENTIVE medicine
KW - HEALTH promotion
N1 - Accession Number: 25317763; SAMUEL, MICHAEL C. VUGIA, DUC J. 1 KOEHLER, KATHLEEN M. 2 MARCUS, RUTHANNE 3 DENEEN, VALERIE 4 DAMASKE, BARBARA 5 SHIFERAW, BELETSHACHEW 6 HADLER, JAMES 3 HENAO, OLGA L. ANGULO, FREDERICK J. 7; Affiliation: 1: California Emerging Infections Program/California Department of Health Services Oakland, CA 2: Center for Food Safety and Applied Nutrition Food and Drug Administration College Park, MD 3: Connecticut Emerging Infections Program New Haven, CT 4: Minnesota Emerging Infections Program St. Paul, MN 5: New York Emerging Infections Program Albany, NY 6: Oregon Department of Human Services Portland, OR 7: Centers for Disease Control and Prevention; Source Info: May2007, Vol. 27 Issue 2, p219; Subject Term: FOODBORNE diseases; Subject Term: RESEARCH; Subject Term: FOOD consumption -- Research; Subject Term: OLDER people -- Health; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: YOUNG adults -- Diseases; Subject Term: FOOD -- Safety measures; Subject Term: PREVENTIVE medicine; Subject Term: HEALTH promotion; Number of Pages: 14p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1745-4565.2007.00074.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - B'Hymer, C.
AU - Cheever, K. L.
T1 - Evaluation of Extraction Conditions and Use of HPLC-MS for the Simultaneous Determination of Acrylamide and its Primary Metabolite, N-Acetyl-S-(2-carbamoylethyl)cysteine, in Human Urine.
JO - Journal of Liquid Chromatography & Related Technologies
JF - Journal of Liquid Chromatography & Related Technologies
Y1 - 2007/05//
VL - 30
IS - 9/10
M3 - Article
SP - 1303
EP - 1316
PB - Taylor & Francis Ltd
SN - 10826076
AB - Extraction conditions were evaluated for the simultaneous determination of acrylamide and its primary metabolite, N-Acetyl-S-(2-carbamoylethyl)cysteine (NACEC), in human urine. Acrylamide is an animal carcinogen and a human neurotoxicant; and it is widely used within industry. The toxicity of acrylamide makes it a health concern, and the use of its metabolite, NACEC, as a biomarker of exposure would be of value in the prevention of occupational diseases. Sample preparation studies evaluating several different types of solid-phase extraction (SPE) cartridges and different buffered or acidic matrices of standing urine samples were conducted. Measurement of acrylamide and NACEC was by reversed-phase high performance liquid chromatography (HPLC) with a mobile phase gradient. Detection for quantification was by single ion monitoring using electrospray mass spectrometry (MS). A basic method validation, using the final optimized SPE conditions, was conducted. Recovery studies of fortified urine samples at various concentration levels demonstrated good accuracy and precision; recovery varied between 97 and 108% for acrylamide and with relative standard deviations (RSD) of 7.6% or less. Recovery for the NACEC metabolite varied between 97 and 102% with RSD of 10% or less. The limit of detection (LOD) for the optimized procedure was found to range from 0.02 to 0.03 µg/mL for acrylamide and 0.1 to 0.2 µg/mL for NACEC in urine, using two chromatographic columns of different production lots. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Liquid Chromatography & Related Technologies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - ACRYLAMIDE
KW - METABOLITES
KW - URINALYSIS
KW - BIOCHEMICAL markers
KW - DISEASES
KW - Acrylamide
KW - HPLC-MS
KW - N-Acetyl-S-(2-carbamoylethyl)cysteine
KW - SPE
KW - Urine
N1 - Accession Number: 24654301; B'Hymer, C. 1; Email Address: cbhymer@cdc.gov Cheever, K. L. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; Source Info: 2007, Vol. 30 Issue 9/10, p1303; Subject Term: HIGH performance liquid chromatography; Subject Term: ACRYLAMIDE; Subject Term: METABOLITES; Subject Term: URINALYSIS; Subject Term: BIOCHEMICAL markers; Subject Term: DISEASES; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: HPLC-MS; Author-Supplied Keyword: N-Acetyl-S-(2-carbamoylethyl)cysteine; Author-Supplied Keyword: SPE; Author-Supplied Keyword: Urine; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/10826070701274866
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106173818
T1 - Helping consumers make more healthful food choices: consumer views on modifying food labels and providing point-of-purchase nutrition information at quick-service restaurants.
AU - Lando AM
AU - Labiner-Wolfe J
Y1 - 2007/05//May/Jun2007
N1 - Accession Number: 106173818. Language: English. Entry Date: 20071019. Revision Date: 20150820. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed. Special Interest: Nutrition. Grant Information: US Department of Health and Human Services. NLM UID: 101132622.
KW - Consumer Attitudes
KW - Consumer Health Information
KW - Food Labeling
KW - Food Services
KW - Emblems and Insignia
KW - External Validity
KW - Focus Groups
KW - Food Labeling -- Utilization
KW - Funding Source
KW - Interview Guides
KW - Portion Size
KW - Purposive Sample
KW - Qualitative Studies
KW - United States
KW - Videorecording
KW - Human
SP - 157
EP - 163
JO - Journal of Nutrition Education & Behavior
JF - Journal of Nutrition Education & Behavior
JA - J NUTR EDUC BEHAV
VL - 39
IS - 3
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVES: To understand consumer (1) interest in nutrition information on food labels and quick-service restaurant menu boards and (2) reactions to modifying this information to help highlight calories and more healthful choices. DESIGN: Eight consumer focus groups, using a guide and stimuli. SETTING: Focus group discussions in 4 US cities. PARTICIPANTS: A total of 68 consumers, with 7 to 10 per focus group. ANALYSIS: Authors prepared detailed summaries of discussions based on observation. Video recordings and transcripts were used to cross-check summaries. Data were systematically reviewed, synthesized, and analyzed. PHENOMENON OF INTEREST: Consumer views on alternative presentations of nutrition information on packaged food items and quick-service restaurant menu boards. RESULTS: Participants (1) were interested in having nutrition information available, but would not use it at every eating occasion; (2) thought that food products typically consumed at 1 eating occasion should be labeled as a single serving; and (3) indicated that an icon on labels and menu boards that signaled more healthful options could be helpful. CONCLUSIONS AND IMPLICATIONS: Findings provide a basis for the development of more systematic studies to better understand whether alternative presentations of nutrition information would help consumers.
SN - 1499-4046
AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA. amy.lando@fda.hhs.gov
U2 - PMID: 17493566.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Harper, Martin
AU - Lee, Eun Gyung
AU - Harvey, Bruce
AU - Beard, Michael
T1 - The Effect of a Proposed Change to Fiber-Counting Rules in ASTM International Standard D7200-06.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/05//
VL - 4
IS - 5
M3 - Article
SP - 42
EP - 45
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article discusses on cleavage fragments and asbestiform fibres. It states that fibers in the ASTM International Standard D7200-06 was tested using materials that were expected to contain a large proportion of particles meeting the current NIOSH definition of a fiber but where those particles would be predominantly cleavage fragments of amphibole mineral. The extent to which asbestiform fibers might also be designated as nonasbestiform under the proposed change has not been addressed.
KW - Scission (Chemistry)
KW - Amphiboles
KW - Taconite
KW - Asbestos fibers
KW - Inorganic fibers
KW - Rocks -- Cleavage
N1 - Accession Number: 75127742; Ashley, Kevin; Harper, Martin 1; Lee, Eun Gyung 1; Harvey, Bruce 2; Beard, Michael 2; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health. Morgantown, West Virginia; 2: Microanalytical Sciences Department, RTI International. Research Triangle Park, North Carolina; Issue Info: May2007, Vol. 4 Issue 5, p42; Thesaurus Term: Scission (Chemistry); Subject Term: Amphiboles; Subject Term: Taconite; Subject Term: Asbestos fibers; Subject Term: Inorganic fibers; Subject Term: Rocks -- Cleavage; NAICS/Industry Codes: 212210 Iron Ore Mining; Number of Pages: 4p; Document Type: Article
L3 - 10.1080/15459620701246414
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Heitbrink, William A.
AU - Evans, Douglas E.
AU - Peters, Thomas M.
AU - Slavin, Thomas J.
T1 - Characterization and Mapping of Very Fine Particles in an Engine Machining and Assembly Facility.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/05//
VL - 4
IS - 5
M3 - Article
SP - 341
EP - 351
PB - Taylor & Francis Ltd
SN - 15459624
AB - Very fine particle number and mass concentrations were mapped in an engine machining and assembly facility in the winter and summer. A condensation particle counter (CPC) was used to measure particle number concentrations in the 0.01 μ m to 1 μ m range, and an optical particle counter (OPC) was used to measure particle number concentrations in 15 channels between 0.3 μ m and 20 μ m. The OPC measurements were used to estimate the respirable mass concentration. Very fine particle number concentrations were estimated by subtracting the OPC particle number concentrations from 0.3 μ m to 1 μ m from the CPC number concentrations. At specific locations during the summer visit, an electrical low pressure impactor was used to measure particle size distribution from 0.07 μ m to 10 μ m in 12 channels. The geometric mean ratio of respirable mass concentration estimated from the OPC to the gravimetrically measured mass concentration was 0.66 with a geometric standard deviation of 1.5. Very fine particle number concentrations in winter were substantially greater where direct-fire natural gas heaters were operated (7.5 × 105 particles/cm3) than where steam was used for heat (3 × 105 particles/cm3). During summer when heaters were off, the very fine particle number concentrations were below 105 particles/cm3, regardless of location. Elevated very fine particle number concentrations were associated with machining operations with poor enclosures. Whereas respirable mass concentrations did not vary noticeably with season, they were greater in areas with poorly fitting enclosures (0.12 mg/m3) than in areas where state-of-the-art enclosures were used (0.03 mg/m3). These differences were attributed to metalworking fluid mist that escaped from poorly fitting enclosures. Particles generated from direct-fire natural gas heater operation were very small, with a number size distribution modal diameter of less than 0.023 μ m. Aerosols generated by machining operations had number size distributions modes in the 0.023 μ m to 0.1 μ m range. However, multiple modes in the mass size distributions estimated from OPC measurements occurred in the 2-20 μ m range. Although elevated, very fine particle concentrations and respirable mass concentrations were both associated with poorly enclosed machining operations; the operation of the direct-fire natural gas heaters resulted in the greatest very fine particle concentrations without elevating the respirable mass concentration. These results suggest that respirable mass concentration may not be an adequate indicator for very fine particle exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Condensation
KW - Particles
KW - Respiration
KW - Aerosols (Sprays)
KW - Engines -- Maintenance & repair
KW - Automobile repair shops
KW - aerosol
KW - combustion aerosol
KW - engine plant
KW - machining
KW - metalworking fluid
KW - ultra fine aerosol
N1 - Accession Number: 75127745; Heitbrink, William A. 1; Evans, Douglas E. 2; Peters, Thomas M. 1; Slavin, Thomas J. 3; Affiliations: 1: Department of Occupational and Environmental Health, University of Iowa. Iowa City. Iowa; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health. Cincinnati. Ohio; 3: International Truck and Engine Corporation. Warrenville. Illinois; Issue Info: May2007, Vol. 4 Issue 5, p341; Thesaurus Term: Condensation; Thesaurus Term: Particles; Thesaurus Term: Respiration; Thesaurus Term: Aerosols (Sprays); Subject Term: Engines -- Maintenance & repair; Subject Term: Automobile repair shops; Author-Supplied Keyword: aerosol; Author-Supplied Keyword: combustion aerosol; Author-Supplied Keyword: engine plant; Author-Supplied Keyword: machining; Author-Supplied Keyword: metalworking fluid; Author-Supplied Keyword: ultra fine aerosol; NAICS/Industry Codes: 811118 Other Automotive Mechanical and Electrical Repair and Maintenance; NAICS/Industry Codes: 811119 Other automotive mechanical and electrical repair and maintenance; NAICS/Industry Codes: 811122 Automotive Glass Replacement Shops; NAICS/Industry Codes: 811191 Automotive Oil Change and Lubrication Shops; NAICS/Industry Codes: 811198 All Other Automotive Repair and Maintenance; NAICS/Industry Codes: 811111 General Automotive Repair; NAICS/Industry Codes: 811112 Automotive Exhaust System Repair; NAICS/Industry Codes: 811113 Automotive Transmission Repair; NAICS/Industry Codes: 811411 Home and Garden Equipment Repair and Maintenance; NAICS/Industry Codes: 811310 Commercial and Industrial Machinery and Equipment (except Automotive and Electronic) Repair and Maintenance; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/15459620701290081
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bakke, Berit
AU - Stewart, Patricia A.
AU - Waters, Martha A.
T1 - Uses of and Exposure to Trichloroethylene in U.S. Industry: A Systematic Literature Review.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/05//
VL - 4
IS - 5
M3 - Article
SP - 375
EP - 390
PB - Taylor & Francis Ltd
SN - 15459624
AB - This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address uses of and exposures to TCE were identified from MEDLINE, TOXLINE, NIOSHTIC, the NIOSH Health Hazard Evaluation database (keywords: chlorinated solvents and trichloroethylene), and in other reviews. This search was complemented by reviewing the reference lists from the identified literature. The collected information was systematized by the Standard Industrial Classification (SIC) system, and measurement data reported in the literature were summarized in a database. TCE use was extensive from the early 1920s through the 1970s mainly as a degreasing agent in metal-fabricating operations. After the 1970s it became less popular because of environmental concerns. TCE historically has had a multitude of uses in many other industries, e.g., dry cleaning, textile, electronics, leather, and rubber. Also, many products like adhesives, drugs, paints, inks, and various industrial products have contained TCE. It was banned as a food additive and in cosmetics in 1977. The arithmetic mean (AM) of the measurements across all industries and decades was 38.2 ppm. The highest personal and area air levels were reported in vapor degreasing (AM of 44.6 ppm). Most TCE measurements were performed in the 1950s, 1970s, and 1980s. The data described here could be used by exposure assessors as is to identify the presence and approximate levels of exposure. Using the same information as a basis should increase the reliability of the assessments, making it easier to compare both the exposure assessment methods and the epidemiologic results across different studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Trichloroethylene
KW - Industrial hygiene
KW - CLASSIFICATION
KW - Epidemiology
KW - Brain cancer
KW - Solid freeform fabrication
KW - Industries
KW - United States
KW - case-control study
KW - degreasing
KW - exposure assessment
KW - SIC
KW - trichloroethylene
N1 - Accession Number: 75127741; Bakke, Berit 1; Stewart, Patricia A. 2; Waters, Martha A. 3; Affiliations: 1: Division of Cancer Epidemiology and Genetics, National Cancer Institute. Rockville, Maryland,National Institute of Occupational Health. Oslo. Norway; 2: Division of Cancer Epidemiology and Genetics, National Cancer Institute. Rockville, Maryland; 3: National Institute for Occupational Safety and Health. Cincinnati, Ohio; Issue Info: May2007, Vol. 4 Issue 5, p375; Thesaurus Term: Trichloroethylene; Thesaurus Term: Industrial hygiene; Thesaurus Term: CLASSIFICATION; Thesaurus Term: Epidemiology; Subject Term: Brain cancer; Subject Term: Solid freeform fabrication; Subject Term: Industries; Subject: United States; Author-Supplied Keyword: case-control study; Author-Supplied Keyword: degreasing; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: SIC; Author-Supplied Keyword: trichloroethylene; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 16p; Document Type: Article
L3 - 10.1080/15459620701301763
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106167547
T1 - The effect of a proposed change to fiber-counting rules in ASTM International Standard D7200-06...The American Society for Testing and Materials (ASTM)
AU - Harper M
AU - Lee EG
AU - Harvey B
AU - Beard M
A2 - Ashley K
Y1 - 2007/05//
N1 - Accession Number: 106167547. Language: English. Entry Date: 20071012. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Asbestos -- Analysis
KW - Environmental Monitoring -- Standards
KW - National Institute for Occupational Safety and Health
KW - Minerals -- Analysis
KW - United States
SP - D42
EP - 5
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
U2 - PMID: 17458031.
DO - 10.1080/15459620701246414
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Valcin, Martin
AU - Henneberger, Paul K.
AU - Kullman, Greg J.
AU - Umbach, David M.
AU - London, Stephanie J.
AU - Alavanja, Michael C. R.
AU - Sandler, Dale P.
AU - Hoppin, Jane A.
T1 - Chronic Bronchitis Among Nonsmoking Farm Women in the Agricultural Health Study.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/05//
VL - 49
IS - 5
M3 - Article
SP - 574
EP - 583
SN - 10762752
AB - The article focuses on the risk of chronic bronchitis among nonsmoking farm women in the U.S. It is stated that farm work includes exposure to occupational dust and grain, which leads to chronic bronchitis. According to studies of chronic bronchitis in farming populations, the disease is work-related, and inhalation exposures to hazardous substances such as organic dusts, bacteria, endotoxins, and gases leads to chronic bronchitis risk. Recent data from the U.S. shows that chronic bronchitis increased in both men and women during 1982-1996, and is now more in women. It is stated that nonsmoking women were exposed to occupational risk factors, such as pesticides and other chemicals, which resulted in chronic bronchitis.
KW - WOMEN agricultural laborers
KW - DISEASES
KW - BRONCHITIS
KW - CHRONIC diseases
KW - SMOKING
KW - OCCUPATIONAL hazards
KW - HAZARDOUS substances
KW - PESTICIDES
KW - DISEASES -- Risk factors
KW - UNITED States
N1 - Accession Number: 25227403; Valcin, Martin 1,2 Henneberger, Paul K. 2 Kullman, Greg J. 2 Umbach, David M. 3 London, Stephanie J. 1 Alavanja, Michael C. R. 4 Sandler, Dale P. 1 Hoppin, Jane A. 1; Email Address: hoppin1@niehs.nih.gov; Affiliation: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina. 2: Field Studies Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia. 3: Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina. 4: Occupational Epidemiology Branch, National Cancer Institute, NIH, DHHS, Rockville, Maryland.; Source Info: May2007, Vol. 49 Issue 5, p574; Subject Term: WOMEN agricultural laborers; Subject Term: DISEASES; Subject Term: BRONCHITIS; Subject Term: CHRONIC diseases; Subject Term: SMOKING; Subject Term: OCCUPATIONAL hazards; Subject Term: HAZARDOUS substances; Subject Term: PESTICIDES; Subject Term: DISEASES -- Risk factors; Subject Term: UNITED States; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; Number of Pages: 10p; Document Type: Article
L3 - 10.1097/JOM.0b013e3180577768
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, Rakhi B.
AU - Tawakkul, Mobin A.
AU - Khan, Mansoor A.
T1 - Process analytical technology: Chemometric analysis of Raman and near infra-red spectroscopic data for predicting physical properties of extended release matrix tablets.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/05//
VL - 96
IS - 5
M3 - Article
SP - 1356
EP - 1365
SN - 00223549
AB - The purpose of this work was to develop a correlation between pharmaceutical properties such as hardness, porosity, and content with prediction models employed using Raman and near infra-red (NIR) spectroscopic methods. Metoprolol tartrate tablets were prepared by direct compression and wet granulation methods. NIR spectroscopy and chemical imaging, and Raman spectra were collected, and hardness, porosity, and dissolution were measured. The NIR PLS model showed a validated correlation coefficient of >0.90 for the predicted versus measured porosity, hardness, and amount of drug with raw and second derivative NIR spectra. Raman spectra correlated porosity of the tablets using raw data for directly compressed tablets and wet granulated tablets (r2 > 0.90). A very close root-mean square error of calibration (RMSEC) and root-mean square error of prediction (RMSEP) values were found in all the cases indicating validity of the calibration models. Raman spectroscopy was used for the first time to predict physical quality attribute such as porosity successfully. Chemical imaging utilizing NIR detector also demonstrated to show physical changes due to compression differences. In conclusion, sensor technologies can be potentially used to predict physical parameters of the matrix tablets. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1356–1365, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - POROSITY
KW - RAMAN spectroscopy
KW - INFRARED spectroscopy
KW - METOPROLOL
KW - compression
KW - hardness
KW - image analysis
KW - porosity
KW - sensor technology
N1 - Accession Number: 24891672; Shah, Rakhi B. 1 Tawakkul, Mobin A. 1 Khan, Mansoor A. 1; Email Address: Mansoor.khan@fda.hhs.gov); Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Source Info: May2007, Vol. 96 Issue 5, p1356; Subject Term: DRUGS; Subject Term: POROSITY; Subject Term: RAMAN spectroscopy; Subject Term: INFRARED spectroscopy; Subject Term: METOPROLOL; Author-Supplied Keyword: compression; Author-Supplied Keyword: hardness; Author-Supplied Keyword: image analysis; Author-Supplied Keyword: porosity; Author-Supplied Keyword: sensor technology; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1002/jps.20931
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Healthy Aging Starts with Healthful Eating
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2007/05//
VL - 107
IS - 5
M3 - Editorial
SP - 723
EP - 723
SN - 00028223
N1 - Accession Number: 24866429; Moritsugu, Kenneth P. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: May2007, Vol. 107 Issue 5, p723; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2007.03.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106193972
T1 - Healthy aging starts with healthful eating.
AU - Moritsugu KP
Y1 - 2007/05//
N1 - Accession Number: 106193972. Language: English. Entry Date: 20071116. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 7503061.
KW - Aging -- Physiology
KW - Diet -- In Old Age
KW - Health Status -- In Old Age
KW - Physical Activity -- In Old Age
KW - Aged
KW - Female
KW - Male
KW - Quality of Life
SP - 723
EP - 723
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 107
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Department of Health and Human Services.
U2 - PMID: 17467359.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yamada, Hirotomo
AU - Suzuki, Kaoru
AU - Koizumi, Shinji
T1 - GENE EXPRESSION PROFILE IN HUMAN CELLS EXPOSED TO ZINC.
JO - Journal of Toxicological Sciences
JF - Journal of Toxicological Sciences
Y1 - 2007/05//
VL - 32
IS - 2
M3 - Article
SP - 193
EP - 196
SN - 03881350
AB - Although Zn is an essential trace metal for humans, a comprehensive view of its effects on cellular functions has not been obtained. We used a DNA microarray to assess transcriptional alterations in human HeLa cells after exposure to a moderate concentration of Zn (100 µM ZnSO4). Out of 9,182 human genes, expression was increased in 7 genes and decreased in 4 genes twofold or greater. Four of the 7 upregulated genes were those coding for metallothionein isoforms or related proteins. An unexpectedly small extent of changes in gene expression might reflect rapid sequestration of Zn ions by metallothioneins, and the absence of most of the other protective responses indicated the non-toxic nature of Zn at this concentration. Comparison with our previous DNA microarray results for 5 µM CdSO4-exposed HeLa cells revealed several genes that are regulated by both metals in parallel, and a gene reciprocally regulated by them. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicological Sciences is the property of Japanese Society of Toxicology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALS
KW - DNA microarrays
KW - CELLS
KW - GENES
KW - METALLOTHIONEIN
KW - PROTEINS
KW - GENE expression
KW - DNA microarray
KW - Human HeLa cells
KW - Metallothionein
KW - Zinc
N1 - Accession Number: 25453252; Yamada, Hirotomo 1 Suzuki, Kaoru 1 Koizumi, Shinji 1; Email Address: koizumi@h.jniosh.go.jp; Affiliation: 1: Mechanism of Health Effect Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Source Info: May2007, Vol. 32 Issue 2, p193; Subject Term: METALS; Subject Term: DNA microarrays; Subject Term: CELLS; Subject Term: GENES; Subject Term: METALLOTHIONEIN; Subject Term: PROTEINS; Subject Term: GENE expression; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: Human HeLa cells; Author-Supplied Keyword: Metallothionein; Author-Supplied Keyword: Zinc; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; NAICS/Industry Codes: 332811 Metal Heat Treating; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106129185
T1 - The impact of a quality improvement program on systems, processes, and structures in medical clinics.
AU - McInnes DK
AU - Landon BE
AU - Wilson IB
AU - Hirschhorn LR
AU - Marsden PV
AU - Malitz F
AU - Barini-Garcia M
AU - Cleary PD
Y1 - 2007/05//2007 May
N1 - Accession Number: 106129185. Language: English. Entry Date: 20070803. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Quality Assurance. Grant Information: Grant AHRQ (R-01HS10227). NLM UID: 0230027.
KW - Ambulatory Care Facilities -- Evaluation
KW - HIV Infections -- Therapy
KW - Organizational Change
KW - Quality Improvement
KW - Quality of Health Care -- Evaluation
KW - Adult
KW - Chi Square Test
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Linear Regression
KW - Male
KW - Middle Age
KW - P-Value
KW - Patient Satisfaction
KW - T-Tests
KW - Human
SP - 463
EP - 471
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0025-7079
AD - Department of Health Care Policy, Division of General Medicine, Health Resources and Services Administration HIV/AIDS Bureau, Rockville, Maryland
U2 - PMID: 17446833.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Barror, Richard F.
T1 - USPHS: ENGINEERING DIPLOMACY.
JO - Military Engineer
JF - Military Engineer
J1 - Military Engineer
PY - 2007/05//May/Jun2007
Y1 - 2007/05//May/Jun2007
VL - 99
IS - 647
M3 - Article
SP - 77
EP - 79
SN - 00263982
AB - The article focuses on the effort of the U.S. Public Health Service to enable its mission to go global, in terms of the health and aid of the country's friends and allies. According to sources, military engineers played an increasing role in the U.S. Department of Health and Human Services' global health objective, which is to improve the human condition around the world. Moreover, it was inferred that they bring insights and expertise to the decision process in resolving public health issues.
KW - PUBLIC health
KW - MILITARY engineers
KW - UNITED States. Public Health Service
KW - UNITED States. Dept. of Health & Human Services
KW - UNITED States
N1 - Accession Number: 25064730; Source Information: May/Jun2007, Vol. 99 Issue 647, p77; Subject Term: PUBLIC health; Subject Term: MILITARY engineers; Subject Term: UNITED States. Public Health Service; Subject Term: UNITED States. Dept. of Health & Human Services; Subject Term: ; Geographic Subject: UNITED States; Geographic Subject: ; Number of Pages: 3p; ; Document Type: Article;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Wright, L.K.M.
AU - Pearson, E.C.
AU - Hammond, T.G.
AU - Paule, M.G.
T1 - Behavioral effects associated with chronic ketamine or remacemide exposure in rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/05//
VL - 29
IS - 3
M3 - Article
SP - 348
EP - 359
SN - 08920362
AB - Abstract: The effects of chronic exposure to ketamine or remacemide on the acquisition and performance of food-reinforced operant behaviors was assessed in female Sprague–Dawley rats. Ketamine is an anesthetic N-methyl-d-aspartate (NMDA) receptor antagonist, whereas remacemide is an active central nervous system compound with both NMDA receptor antagonist and sodium channel blocking properties. Learning, audio/visual discrimination and motivation were modeled using incremental repeated acquisition (IRA), audio/visual discrimination (AVD) and progressive ratio (PR) tasks, respectively. Ketamine (10 or 100 mg/kg/day), remacemide (100 or 150 mg/kg/day) or water was administered daily (7 days/week) via orogastric gavage beginning on postnatal day (PND) 23 and continuing until PND 257. Monday through Friday behavioral assessments began on PND 27 and continued until PND 383. Chronic treatment with the high dose of ketamine decreased response rate in all tasks suggesting decreased motivation or motoric capabilities. Chronic treatment with ketamine or remacemide had no effect on the acquisition of IRA task performance at any dose tested. While chronic treatment with either high-dose ketamine or low-dose remacemide only delayed the acquisition of AVD task performance for a brief period midway through treatment, chronic treatment with high-dose remacemide delayed the acquisition of AVD task performance until late in treatment. The findings for ketamine are quite different from those of MK-801 (the prototypic NMDA receptor antagonist) in a previous rat study in which MK-801 severely disrupted the acquisition of both IRA and AVD task performances. These observations suggest important differences in the mechanism of action between ketamine and MK-801. For example, ketamine has a much lower binding affinity than MK-801 for the NMDA receptor, the dopamine transporter and the dopamine D2 receptor. In addition, the findings for remacemide observed in rats are in marked contrast with those seen in monkeys where chronic remacemide had profound disruptive effects on the acquisition of both IRA and AVD task performances and suggest important species differences. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KETAMINE
KW - ANESTHESIA adjuvants
KW - CHLOROBENZENE
KW - NERVOUS system
KW - Ketamine
KW - N-methyl-d-aspartate (NMDA) receptors
KW - Operant behavior
KW - Remacemide
KW - Sodium channels
N1 - Accession Number: 25185747; Wright, L.K.M. 1,2 Pearson, E.C. 3 Hammond, T.G. 3 Paule, M.G. 1,2; Email Address: merle.paule@fda.hhs.gov; Affiliation: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205-7199, USA 2: Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA 3: Safety Assessment, AstraZeneca, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK; Source Info: May2007, Vol. 29 Issue 3, p348; Subject Term: KETAMINE; Subject Term: ANESTHESIA adjuvants; Subject Term: CHLOROBENZENE; Subject Term: NERVOUS system; Author-Supplied Keyword: Ketamine; Author-Supplied Keyword: N-methyl-d-aspartate (NMDA) receptors; Author-Supplied Keyword: Operant behavior; Author-Supplied Keyword: Remacemide; Author-Supplied Keyword: Sodium channels; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ntt.2006.12.004
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Ferguson, S.A.
AU - Smith, M.E.
AU - Garey, J.D.
AU - Paule, M.G.
T1 - Long-term locomotor activity assessments appear insensitive to acrylamide treatment in young adult rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/05//
VL - 29
IS - 3
M3 - Abstract
SP - 404
EP - 404
SN - 08920362
N1 - Accession Number: 25185779; Ferguson, S.A. 1 Smith, M.E. 1 Garey, J.D. 1 Paule, M.G. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR; Source Info: May2007, Vol. 29 Issue 3, p404; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2007.03.032
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Smith, M.E.
AU - Paule, M.G.
AU - Garey, J.D.
AU - Ferguson, S.A.
T1 - Morris water maze and dry-land complex maze performance appear insensitive to acrylamide treatment in young adult rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/05//
VL - 29
IS - 3
M3 - Abstract
SP - 404
EP - 405
SN - 08920362
N1 - Accession Number: 25185780; Smith, M.E. 1 Paule, M.G. 1 Garey, J.D. 1 Ferguson, S.A. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR; Source Info: May2007, Vol. 29 Issue 3, p404; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.ntt.2007.03.033
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Garey, J.
AU - Paule, M.G.
T1 - Chronic low-dose acrylamide exposure reduces appetitive motivation in Fischer 344 rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/05//
VL - 29
IS - 3
M3 - Abstract
SP - 407
EP - 407
SN - 08920362
N1 - Accession Number: 25185787; Garey, J. 1 Paule, M.G. 1; Affiliation: 1: National Center for Toxicological Research/FDA Jefferson, AR; Source Info: May2007, Vol. 29 Issue 3, p407; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2007.03.040
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25185787&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Paule, M.G.
AU - Garey, J.
T1 - Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) performance in Fischer 344 rats through eight months of age
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/05//
VL - 29
IS - 3
M3 - Abstract
SP - 407
EP - 407
SN - 08920362
N1 - Accession Number: 25185788; Paule, M.G. 1 Garey, J. 1; Affiliation: 1: National Center for Toxicological Research/FDA Jefferson, AR; Source Info: May2007, Vol. 29 Issue 3, p407; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2007.03.041
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoppin, Jane A.
AU - Umbach, David M.
AU - Kullman, Greg J.
AU - Henneberger, Paul K.
AU - London, Stephanie J.
AU - Alavanja, Michael C. R.
AU - Sandler, Dale P.
T1 - Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2007/05//
VL - 64
IS - 5
M3 - Article
SP - 334
EP - 342
SN - 13510711
AB - Background: Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers. Methods: Using the 1993-7 enrolment data from the Agricultural Health Study, we conducted a cross- sectional study of occupational risk factors for farmer's lung among ∼50 000 farmers and farm spouses in Iowa and North Carolina using hierarchical logistic regression controlling for age, state, and smoking status. Participants provided information on agricultural exposures, demographic characteristics, and medical history via self-administered questionnaires. Approximately 2% of farmers (n = 481) and 0.2% of spouses (n = 51) reported doctor-diagnosed farmer's lung during their lifetime. We assessed farmers and spouses separately due to different information on occupational exposure history. Only pesticide exposures represented lifetime exposure history, all other farm exposures represented current activities at enrolment. Results: Among farmers, handling silage (OR = 1 .41, 95% CI 1 .10 to 1 .82), high pesticide exposure events (OR = 1.75, 95% CI 1.39 to 2.21), and ever use of organochlorine (OR = 1.34, 95% CI 1.04 to 1.74) and carbamate pesticides (OR = 1.32, 95% CI 1.03 to 1.68) were associated with farmer's lung in mutually-adjusted models. The insecticides DDT, lindane, and aldicarb were positively associated with farmer's lung among farmers. Current animal exposures, while not statistically significant, were positively associated with farmer's lung, particularly for poultry houses (OR = 1.55, 95% CI 0.93 to 2.58) and dairy cattle (OR = 1.28, 95% CI 0.86 to 1 .89). The occupational data were more limited for spouses; however, we saw similar associations for dairy cattle (OR = 1.50, 95% CI 0.72 to 3.14) and organochlorine pesticides (OR = 1.29, 95% CI 0.64 to 2.59). Conclusion: While historic farm exposures may contribute to the observed associations with pesticides, these results suggest that organochlorine and carbamate pesticides should be further evaluated as potential risk factors for farmer's lung. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pesticides
KW - Insecticides
KW - Pests -- Control
KW - Dairy cattle
KW - Farmers -- United States
KW - Lungs -- Dust diseases
KW - Hypersensitivity pneumonitis
KW - Lung diseases
KW - Organochlorine compounds
KW - United States
N1 - Accession Number: 24987131; Hoppin, Jane A. 1; Email Address: hoppin1@niehs.nihl.gov; Umbach, David M. 2; Kullman, Greg J. 3; Henneberger, Paul K. 3; London, Stephanie J. 1; Alavanja, Michael C. R. 4; Sandler, Dale P. 1; Affiliations: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 2: Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.; 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Department of Health and Human Sciences, Morgantown, West Virginia, USA.; 4: Occupational Epidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Sciences, Rockville, Maryland, USA.; Issue Info: May2007, Vol. 64 Issue 5, p334; Thesaurus Term: Pesticides; Thesaurus Term: Insecticides; Thesaurus Term: Pests -- Control; Thesaurus Term: Dairy cattle; Subject Term: Farmers -- United States; Subject Term: Lungs -- Dust diseases; Subject Term: Hypersensitivity pneumonitis; Subject Term: Lung diseases; Subject Term: Organochlorine compounds; Subject: United States; NAICS/Industry Codes: 112120 Dairy Cattle and Milk Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1136/oem.2006.028480
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bolen, Aimee R.
AU - Henneberger, Paul K.
AU - Xiaoming Hang
AU - Sama, Susan R.
AU - Preusse, Peggy A.
AU - Rosiello, Richard A.
AU - Milton, Donald K.
T1 - The validation of work-related self-reported asthma exacerbation.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2007/05//
VL - 64
IS - 5
M3 - Article
SP - 343
EP - 348
SN - 13510711
AB - Objective: To determine the validity of work-related self-reported exacerbation of asthma using the findings from serial peak expiratory How (PEF) measurements as the standard. Methods: Adults with asthma treated in a health maintenance organisation were asked to conduct serial spirometry testing at home and at work for 3 weeks. Self-reported respiratory symptoms and medication use were recorded in two ways: a daily log completed concurrently with the serial PEF testing and a telephone questionnaire administered after the PEF testing. Three researchers evaluated the serial PEF records and judged whether a work relationship was evident. Results: 95 of 382 (25%) working adults with asthma provided adequate serial PEF data, and 13 of 95 (14%) were judged to have workplace exacerbation of asthma (WEA) based on these data. Self-reported concurrent medication use was the most valid single operational definition, with a sensitivity of 62% and a specificity of 65%. Conclusions: A work-related pattern of self-reported asthma symptoms or medication use was usually not corroborated by serial PEF testing and failed to identify many people who had evidence of WEA based on the serial PEF measurements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Diseases -- Causes & theories of causation
KW - Drugs
KW - Asthma
KW - Obstructive lung diseases
KW - Health maintenance organizations
KW - Spirometry
KW - Asthmatics
KW - Pulmonary function tests
KW - Work environment
N1 - Accession Number: 24987132; Bolen, Aimee R. 1; Henneberger, Paul K. 1; Email Address: pkb0@cdc.gov; Xiaoming Hang 1; Sama, Susan R. 2; Preusse, Peggy A. 3; Rosiello, Richard A. 3; Milton, Donald K. 2; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; 2: Harvard School of Public Health, Boston, Massachusetts, USA.; 3: Clinic Research Department, Worcester, Massachusetts, USA.; Issue Info: May2007, Vol. 64 Issue 5, p343; Thesaurus Term: RESEARCH; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Drugs; Subject Term: Asthma; Subject Term: Obstructive lung diseases; Subject Term: Health maintenance organizations; Subject Term: Spirometry; Subject Term: Asthmatics; Subject Term: Pulmonary function tests; Subject Term: Work environment; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 621491 HMO Medical Centers; NAICS/Industry Codes: 621494 Community health centres; Number of Pages: 6p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1136/oem.2006.028662
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106178915
T1 - The validation of work-related self-reported asthma exacerbation.
AU - Bolen AR
AU - Henneberger PK
AU - Liang X
AU - Sama SR
AU - Preusse PA
AU - Rosiello RA
AU - Milton DK
Y1 - 2007/05//
N1 - Accession Number: 106178915. Language: English. Entry Date: 20071026. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Centers for Disease Control and Prevention. NLM UID: 9422759.
KW - Asthma
KW - Occupational Diseases
KW - Self Report
KW - Adult
KW - Data Analysis Software
KW - Diaries
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Male
KW - Massachusetts
KW - Peak Expiratory Flow Rate
KW - Questionnaires
KW - Sensitivity and Specificity
KW - Spirometry
KW - Telephone
KW - Validation Studies
KW - Human
SP - 343
EP - 348
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 64
IS - 5
PB - BMJ Publishing Group
AB - OBJECTIVE: To determine the validity of work-related self-reported exacerbation of asthma using the findings from serial peak expiratory flow (PEF) measurements as the standard. METHODS: Adults with asthma treated in a health maintenance organisation were asked to conduct serial spirometry testing at home and at work for 3 weeks. Self-reported respiratory symptoms and medication use were recorded in two ways: a daily log completed concurrently with the serial PEF testing and a telephone questionnaire administered after the PEF testing. Three researchers evaluated the serial PEF records and judged whether a work relationship was evident. RESULTS: 95 of 382 (25%) working adults with asthma provided adequate serial PEF data, and 13 of 95 (14%) were judged to have workplace exacerbation of asthma (WEA) based on these data. Self-reported concurrent medication use was the most valid single operational definition, with a sensitivity of 62% and a specificity of 65%. CONCLUSIONS: A work-related pattern of self-reported asthma symptoms or medication use was usually not corroborated by serial PEF testing and failed to identify many people who had evidence of WEA based on the serial PEF measurements.
SN - 1351-0711
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26501, USA.
U2 - PMID: 17182641.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - CÊTRE-SOSSAH, C. B.
AU - MONTESANO, M. A.
AU - FREEMAN, G. L.
AU - WILLARD, M. T.
AU - COLLEY, D. G.
AU - SECOR, W. E.
T1 - Early responses associated with chronic pathology in murine schistosomiasis.
JO - Parasite Immunology
JF - Parasite Immunology
Y1 - 2007/05//
VL - 29
IS - 5
M3 - Article
SP - 241
EP - 249
PB - Wiley-Blackwell
SN - 01419838
AB - Inbred male CBA/J mice infected with Schistosoma mansoni develop either hypersplenomegaly syndrome (HSS) or moderate splenomegaly syndrome (MSS) by 20 weeks of infection. Pathologically and immunologically, MSS and HSS closely parallel the intestinal and hepatosplenic clinical forms of schistosomiasis in humans, respectively. By 6 weeks after infection, mice that eventually will become MSS develop T cell-stimulatory, cross-reactive idiotypes (CRI) while HSS mice never produce CRI. Because presence of CRI is useful to predict degree of chronic pathology, we used this measure to investigate what other early immunological events occurred in animals destined to develop severe morbidity. At 8 weeks of infection, there was a strong inverse correlation between CRI and splenomegaly, egg counts, and liver hydroxyproline. Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4+ T cells was inversely correlated with serum CRI and directly correlated with spleen size. In contrast, spleen cell intracellular TNF-α and peritoneal cell production of nitric oxide demonstrated positive correlations with CRI and inverse correlations with measures of morbidity. Surprisingly, IL-10 and IFN-γ were not correlated with CRI levels. These studies link chronic pathology to certain immunological responses during the acute phase of schistosomiasis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasite Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCHISTOSOMIASIS
KW - PATHOLOGY
KW - SCHISTOSOMA mansoni
KW - MICE -- Diseases
KW - T cells
KW - cytokines
KW - idiotypes
KW - mice
KW - schistosomiasis
KW - splenomegaly
N1 - Accession Number: 24650175; CÊTRE-SOSSAH, C. B. 1 MONTESANO, M. A. 1 FREEMAN, G. L. 1 WILLARD, M. T. 1 COLLEY, D. G. 1 SECOR, W. E. 1; Email Address: was4@cdc.gov; Affiliation: 1: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA; Source Info: May2007, Vol. 29 Issue 5, p241; Subject Term: SCHISTOSOMIASIS; Subject Term: PATHOLOGY; Subject Term: SCHISTOSOMA mansoni; Subject Term: MICE -- Diseases; Subject Term: T cells; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: idiotypes; Author-Supplied Keyword: mice; Author-Supplied Keyword: schistosomiasis; Author-Supplied Keyword: splenomegaly; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-3024.2007.00939.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vernon, John A.
T1 - Perspectives on Dynamic Optimisation and Control Theory in Treating Hyperlipidaemia.
JO - PharmacoEconomics
JF - PharmacoEconomics
Y1 - 2007/05//
VL - 25
IS - 7
M3 - Article
SP - 533
EP - 535
PB - Springer Science & Business Media B.V.
SN - 11707690
AB - The article discusses various reports published within the issue, including one about the various methods and techniques of dynamic optimization within the context of treating hyperlipidaemia and another on the methods for finding the cost-minimizing treatment on reducing cholesterol level.
KW - BLOOD cholesterol
KW - CHOLESTEROL
N1 - Accession Number: 25752277; Vernon, John A. 1,2,3; Affiliation: 1: Senior Economic Policy Advisor, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, USA 2: Department of Finance, School of Business, Connecticut, USA 3: National Bureau of Economic Research, Cambridge, Massachusetts, USA; Source Info: 2007, Vol. 25 Issue 7, p533; Subject Term: BLOOD cholesterol; Subject Term: CHOLESTEROL; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kelly, William N.
AU - Arellano, Felix M.
AU - Barnes, Joanne
AU - Bergman, Ulf
AU - Edwards, I. Ralph
AU - Fernandez, Alina M.
AU - Freedman, Stephen B.
AU - Goldsmith, David I.
AU - Huang, Kui
AU - Jones, Judith K.
AU - McLeay, Rachel
AU - Moore, Nicholas
AU - Stather, Rosie H.
AU - Trenque, Thierry
AU - Troutman, William G.
AU - van Puijenbroek, Eugene
AU - Williams, Frank
AU - Wise, Robert P.
T1 - Guidelines for submitting adverse event reports for publication.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/05//
VL - 16
IS - 5
M3 - Article
SP - 581
EP - 587
SN - 10538569
AB - Publication of case reports describing suspected adverse effects of drugs and medical products that include herbal and complementary medicines, vaccines, and other biologicals and devices is important for postmarketing surveillance. Publication lends credence to important signals raised in these adverse event reports. Unfortunately, deficiencies in vital information in published cases can often limit the value of such reports by failing to provide sufficient details for either (i) a differential diagnosis or provisional assessment of cause-effect association, or (ii) a reasonable pharmacological or biological explanation. Properly described, a published report of one or more adverse events can provide a useful signal of possible risks associated with the use of a drug or medical product which might warrant further exploration. A review conducted by the Task Force authors found that many major journals have minimal requirements for publishing adverse event reports, and some have none at all. Based on a literature review and our collective experience in reviewing adverse event case reports in regulatory, academic, and industry settings, we have identified information that we propose should always be considered for inclusion in a report submitted for publication. These guidelines have been endorsed by the International Society for Pharmacoepidemiology (ISPE) and the International Society of Pharmacovigilance (ISoP) and are freely available on the societies' web sites. Their widespread distribution is encouraged. ISPE and ISoP urge biomedical journals to adopt these guidelines and apply them to case reports submitted for publication. They also encourage schools of medicine, pharmacy, and nursing to incorporate them into the relevant curricula that address the detection, evaluation, and reporting of suspected drug or other medical product adverse events. Copyright © 2007 Kelly et al. Reproduced with permission by John Wiley & Sons, Ltd. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708247; Kelly, William N. 1; Arellano, Felix M. 2; Barnes, Joanne 3; Bergman, Ulf 4; Edwards, I. Ralph 5; Fernandez, Alina M. 6; Freedman, Stephen B. 7; Goldsmith, David I. 8; Huang, Kui 9; Jones, Judith K. 10; McLeay, Rachel 11; Moore, Nicholas 12; Stather, Rosie H. 11; Trenque, Thierry 13; Troutman, William G. 14; van Puijenbroek, Eugene 15; Williams, Frank 16; Wise, Robert P. 17; Affiliations: 1: William N. Kelly Consulting, Inc., Oldsmar, Florida, USA; 2: Dip Pharm Med, Managing Partner, Risk Management Resources, Bridgewater, NY, USA; 3: University of Auckland, Auckland, New Zealand; 4: Karolinska Institute, Stockholm, Sweden; 5: Uppsala Monitoring Centre, Uppsala, Sweden; 6: TAP Pharmaceutical Products, Inc., Lake Forest, Illinois, USA; 7: The Hospital for Sick Children, Toronto, Canada; 8: Goldsmith Pharmacovigilance and Systems, New York, New York, USA; 9: Pfizer Pharmaceuticals, New York, New York, USA; 10: The Degge Group, Ltd., Arlington, VA, USA; 11: Wolters Kluwer Health, Auckland, New Zealand; 12: Université Victor Segalen, Bordeaux France, & ISOP President; 13: Centre Hospitalier Universitaire, Reims, France; 14: University of New Mexico, Albuquerque, New Mexico, USA; 15: Netherlands Pharmacovigilance Centre, Hertogenbosch, the Netherlands; 16: United States Navy, Bethesda, MD, USA; 17: United States Food and Drug Administration, Rockville, MD, USA; Issue Info: May2007, Vol. 16 Issue 5, p581; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1399
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106140529
T1 - Social networks and their relationship to mental health service use and expenditures among Medicaid beneficiaries.
AU - Kang SH
AU - Wallace NT
AU - Hyun JK
AU - Morris A
AU - Coffman J
AU - Bloom JR
Y1 - 2007/05//
N1 - Accession Number: 106140529. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Instrumentation: Lehman's Quality of Life interview. Grant Information: Grant R01-MH-54136 from the National Institute of Mental Health. NLM UID: 9502838.
KW - Health Care Costs
KW - Medicaid
KW - Mental Health Services -- Economics
KW - Mental Health Services -- Utilization
KW - Support, Psychosocial
KW - Adolescence
KW - Adult
KW - Aged
KW - Coefficient Alpha
KW - Colorado
KW - Data Collection
KW - Female
KW - Funding Source
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Random Sample
KW - Regression
KW - Two-Tailed Test
KW - United States
KW - Human
SP - 689
EP - 695
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 58
IS - 5
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: This study examined the relationship between social networks and mental health services utilization and expenditures. METHODS: A sample of 522 Medicaid mental health consumers was randomly selected from the administrative records of Colorado's Department of Health Care Policy and Financing. The administrative records contain information on utilization of services and expenditures of Medicaid beneficiaries within Colorado's Mental Health Services. In addition to the administrative records, social network and psychosocial data were gathered through longitudinal survey interviews. The interviews were conducted at six-month intervals between 1994 and 1997. Measures used in the regression analysis included demographic characteristics, clinical diagnoses, the social network index, expenditures, and utilization variables. RESULTS: The social network index was positively associated with utilization of and expenditures for inpatient services in local hospitals but negatively associated with expenditures for inpatient services in state hospitals or outpatient services. Relationships with family were negatively related to expenditures for outpatient services. Relationships with friends were positively associated with utilization of and expenditures for psychiatric inpatient services in local hospitals. CONCLUSIONS: Consumers who had higher social network index scores utilized more inpatient psychiatric services in local hospitals and had higher expenditures than those who had lower scores. Consumers who had higher social network index scores also had lower expenditures for inpatient services in state hospitals and outpatient services than those who have lower scores. Findings suggest that social network is associated with mental health utilization and expenditures in various ways, associations that need to be researched further.
SN - 1075-2730
AD - Center for Mental Health Services, 2140 Shattuck Ave., #309, Berkeley, CA 94720. sookang@berkeley.edu.
U2 - PMID: 17463351.
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DB - rzh
ER -
TY - JOUR
AU - Espey, David K.
AU - Baum, Susan L.
AU - Jung, Ann Moore
AU - Kozoll, Richard L.
T1 - The New Mexico Clinical Prevention Initiative: A Statewide Prevention Partnership.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007/05//May/Jun2007
VL - 122
IS - 3
M3 - Article
SP - 292
EP - 301
SN - 00333549
AB - The New Mexico Department of Health and the New Mexico Medical Society invited organizations to participate in an initiative to promote clinical preventive services. The Clinical Preventive Initiative (CPI) focuses on the following interventions based on burden of illness, preventability of the condition, cost, current level of services, availability of leadership, and programmatic support: adult pneumococcal vaccination, tobacco use prevention and cessation, mammography screening, colorectal cancer screening, healthier weight, screening and treatment for chlamydia and gonorrhea, screening and intervention for problem drinking, childhood immunization, and prevention of unintended pregnancy. Specific workgroups plan and implement interventions directed at New Mexico medical practices, practitioners, and health-care systems. Several state measures suggest effectiveness of CPI efforts. CPI is a successful public-private collaboration providing an active forum for statewide clinical prevention policy development, an effective mechanism to achieve greater awareness of prevention and improved delivery of preventive services. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREVENTIVE medicine
KW - MEDICAL care
KW - MEDICAL societies
KW - NEW Mexico. Dept. of Health
KW - NEW Mexico
N1 - Accession Number: 24833584; Espey, David K. 1; Email Address: david.espey@ihs.gov Baum, Susan L. 2 Jung, Ann Moore 3 Kozoll, Richard L. 3,4; Affiliation: 1: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Division of Epidemiology, Indian Health Service, Albuquerque, NM 2: New Mexico Department of Health, Albuquerque, NM 3: New Mexico Medical Society, Albuquerque, NM 4: Los Pinos Family Health, Cuba, NM; Source Info: May/Jun2007, Vol. 122 Issue 3, p292; Subject Term: PREVENTIVE medicine; Subject Term: MEDICAL care; Subject Term: MEDICAL societies; Subject Term: NEW Mexico. Dept. of Health; Subject Term: NEW Mexico; NAICS/Industry Codes: 813920 Professional Organizations; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105982546
T1 - The New Mexico clinical prevention initiative: a statewide prevention partnerships.
AU - Espey DK
AU - Baum SL
AU - Jung AM
AU - Kozoll RL
Y1 - 2007/05//May/Jun2007
N1 - Accession Number: 105982546. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Preventive Health Care -- Administration
KW - Public Health
KW - Health Policy
KW - Interinstitutional Relations
KW - Leadership
KW - New Mexico
KW - Preventive Health Care -- Economics
SP - 292
EP - 301
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 122
IS - 3
PB - Sage Publications Inc.
AB - The New Mexico Department of Health and the New Mexico Medical Society invited organizations to participate in an initiative to promote clinical preventive services. The Clinical Preventive Initiative (CPI) focuses on the following interventions based on burden of illness, preventability of the condition, cost, current level of services, availability of leadership, and programmatic support: adult pneumococcal vaccination, tobacco use prevention and cessation, mammography screening, colorectal cancer screening, healthier weight, screening and treatment for chlamydia and gonorrhea, screening and intervention for problem drinking, childhood immunization, and prevention of unintended pregnancy. Specific workgroups plan and implement interventions directed at New Mexico medical practices, practitioners, and health-care systems. Several state measures suggest effectiveness of CPI efforts.CPI is a successful public-private collaboration providing an active forum for statewide clinical prevention policy development, an effective mechanism to achieve greater awareness of prevention and improved delivery of preventive services.
SN - 0033-3549
AD - Indian Health Service, Division of Epidemiology, 5300 Homestead NE, Albuquerque, NM 87110
U2 - PMID: 17518300.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Gray, Darryl T.
T1 - Point of View.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2007/05//
VL - 32
IS - 10
M3 - Editorial
SP - 1140
EP - 1140
SN - 03622436
AB - The article comments on the paper "Outpatient Lumbar Spine Decompression in 233 Patients 65 years of Age or Older," by Natalie M. Best and Rick C. Sasso. According to the author, the paper did not address the timing of observed inpatient and outpatient complications. He adds that Best and Sasso should indicate how the patients with complications rated their surgical outcomes and their satisfaction, making sure to consider inpatient versus outpatient procedures.
KW - LUMBAR vertebrae
KW - DECOMPRESSION sickness
KW - OLDER patients
KW - SURGICAL complications
KW - PATIENT satisfaction
N1 - Accession Number: 28407790; Gray, Darryl T. 1; Email Address: darryl.gray@ahrq.hhs.gov; Affiliation: 1: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD; Source Info: May2007, Vol. 32 Issue 10, p1140; Subject Term: LUMBAR vertebrae; Subject Term: DECOMPRESSION sickness; Subject Term: OLDER patients; Subject Term: SURGICAL complications; Subject Term: PATIENT satisfaction; Number of Pages: 1p; Document Type: Editorial
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28407790&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yansheng Geng
AU - Chuan-ging Wu
AU - Bhattacharyya, Siba P.
AU - De Tan
AU - Zheng-Ping Guo
AU - Yu, Mei-ying W.
T1 - Parvovirus B19 DNA in Factor VIII concentrates: effects of manufacturing procedures and B19 screening by nucleic acid testing.
JO - Transfusion
JF - Transfusion
Y1 - 2007/05//
VL - 47
IS - 5
M3 - Article
SP - 883
EP - 889
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Parvovirus B19 (B19) is a common contaminant, especially in coagulation factors. Because of B19 transmission by pooled plasma, solvent/detergent treated in 1999, some fractionators initiated minipool nucleic acid testing (NAT) to limit the B19 load in manufacturing pools. In this study, the extent of B19 DNA contamination in commercial Factor VIII concentrates, that is, antihemophilic factor (human) (AHF), manufactured before and after B19 NAT screening was implemented, was determined. STUDY DESIGN AND METHODS: A total of 284 lots representing six AHF products made during 1993 to 1998 and 2001 to 2004 were assayed for B19 DNA by an in-house NAT procedure. Anti-B19 immunoglobulin G (IgG) was also measured. RESULTS: Most lots made during 1993 to 1998 had detectable B19 DNA. The prevalence ranged from 56 to 100 percent and appeared to differ between manufacturers. The highest level of B19 DNA found was 106 genome equivalents (geq or international units [IU]) per mL. Forty percent of the lots tested contained 103 geq (IU) per mL. In comparison, both prevalence and levels in source plasma–derived AHF products made in 2001 to 2004 were lower. Both, however, remained unchanged in the recovered plasma-derived product because B19 NAT screening had not been implemented. Only an intermediate-purity AHF product was positive for the presence of anti-B19 IgG. CONCLUSION: The prevalence and levels of B19 DNA in AHF prepared from B19 NAT unscreened plasma were high but varied among products with different manufacturing procedures. B19 NAT screening of plasma effectively lowered the B19 DNA level in the final products and in the majority of cases rendered it undetectable and hence potentially reduced the risk of B19 transmission. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARVOVIRUSES
KW - NUCLEIC acids
KW - BLOOD coagulation factors
KW - BLOOD plasma
KW - DNA viruses
N1 - Accession Number: 24892475; Yansheng Geng 1 Chuan-ging Wu 1 Bhattacharyya, Siba P. 1 De Tan 1 Zheng-Ping Guo 1 Yu, Mei-ying W. 1; Email Address: mei-ying.yu@fda.hhs.gov.; Affiliation: 1: From the Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.; Source Info: May2007, Vol. 47 Issue 5, p883; Subject Term: PARVOVIRUSES; Subject Term: NUCLEIC acids; Subject Term: BLOOD coagulation factors; Subject Term: BLOOD plasma; Subject Term: DNA viruses; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1537-2995.2007.01205.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24892475&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Bosschere, H.
AU - Wang, Z.
AU - Orlandi, P. A.
T1 - First Diagnosis of Encephalitozoon intestinalis and E. Hellem in a European Brown Hare ( Lepus europaeus) with Kidney Lesions.
JO - Zoonoses & Public Health
JF - Zoonoses & Public Health
Y1 - 2007/05//
VL - 54
IS - 3/4
M3 - Article
SP - 131
EP - 134
PB - Wiley-Blackwell
SN - 18631959
AB - Encephalitozoon intestinalis and Encephalitozoon hellem were diagnosed in the kidneys of a free – ranging European brown hare ( Lepus europaeus) with multifocal wedge-shaped chronic interstitial nephritis using real-time PCR and microarray. This is the first description of these microsporidia species in a European brown hare, which are both potential zoonotic agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Zoonoses & Public Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EUROPEAN hare
KW - KIDNEYS
KW - INTERSTITIAL nephritis
KW - MICROSPORIDIA
KW - ZOONOSES
KW - diagnosis
KW - E. Hellem
KW - Encephalitozoon intestinalis
KW - European brown hare
KW - kidney
KW - molecular methods
N1 - Accession Number: 31359113; De Bosschere, H. 1; Email Address: hendrik.de.bosschere@bruyland.be Wang, Z. 2 Orlandi, P. A. 3; Affiliation: 1: Medical Laboratory Bruyland, Veterinary section, Meiweg 1a, B-8500 Kortrijk, Belgium. 2: Center for Bio/Molecular Science & Engineering, Code 6910, Building 30, Naval Research Laboratory, 4555 Overlook Ave. SW, Washington DC 20375, USA. 3: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.; Source Info: May2007, Vol. 54 Issue 3/4, p131; Subject Term: EUROPEAN hare; Subject Term: KIDNEYS; Subject Term: INTERSTITIAL nephritis; Subject Term: MICROSPORIDIA; Subject Term: ZOONOSES; Author-Supplied Keyword: diagnosis; Author-Supplied Keyword: E. Hellem; Author-Supplied Keyword: Encephalitozoon intestinalis; Author-Supplied Keyword: European brown hare; Author-Supplied Keyword: kidney; Author-Supplied Keyword: molecular methods; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1863-2378.2007.01034.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31359113&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-05310-010
AN - 2007-05310-010
AU - Wright, L. K. M.
AU - Paule, M. G.
T1 - Response sequence difficulty in an incremental repeated acquisition (learning) procedure.
JF - Behavioural Processes
JO - Behavioural Processes
JA - Behav Processes
Y1 - 2007/05//
VL - 75
IS - 1
SP - 81
EP - 84
CY - Netherlands
PB - Elsevier Science
SN - 0376-6357
SN - 1872-8251
AD - Wright, L. K. M., Center for Veterinary Health Sciences, Oklahoma State University, 165 McElroy Hall, Stillwater, OK, US, 74078
N1 - Accession Number: 2007-05310-010. PMID: 17324533 Partial author list: First Author & Affiliation: Wright, L. K. M.; Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20070514. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wright, L. K. M. Major Descriptor: Animal Ethology; Operant Conditioning; Responses; Task Complexity. Minor Descriptor: Rats. Classification: Learning & Motivation (2420). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: May, 2007.
AB - Incremental repeated acquisition (IRA) procedures require subjects to learn a different sequence of behavioral responses during each experimental session with required response sequences increasing incrementally in length as subjects demonstrate mastery of shorter response chains. The purpose of this study was to investigate whether some response sequences are more or less difficult to acquire than others. If true, then sequence difficulty must be considered as a potential confound when attempting to assess the effects of drugs and other experimental manipulations on learning. Accuracy for each response sequence was assessed using control data from two large rodent studies, and each sequence was classified as easy, moderate or hard. Sequences that required responses on adjacent levers were easier (characterized by higher accuracies) to acquire than those that required responses on non-adjacent levers. In addition, sequences that required responses on only two of three response levers were easier to acquire than those that required responses on all three levers. These results provide strong evidence for differing levels of response sequence difficulty in IRA procedures with sequence difficulty seeming to be dependent on whether or not responses are required on adjacent levers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - response sequence difficulty
KW - incremental repeated acquisition procedure
KW - behavioral responses
KW - lever response sequences
KW - rats
KW - learning
KW - 2007
KW - Animal Ethology
KW - Operant Conditioning
KW - Responses
KW - Task Complexity
KW - Rats
KW - 2007
U1 - Sponsor: Oak Ridge Institute for Science and Education. Other Details: By a fellowship through an interagency agreement between the US Department of Energy and the US Food and Drug Administration.. Recipients: Wright, L. K. M.
DO - 10.1016/j.beproc.2007.01.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-05310-010&site=ehost-live&scope=site
UR - linnzi.wright@okstate.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-05311-004
AN - 2007-05311-004
AU - McCarty, Dennis
AU - Gustafson, David H.
AU - Wisdom, Jennifer P.
AU - Ford, Jay
AU - Choi, Dongseok
AU - Molfenter, Todd
AU - Capoccia, Victor
AU - Cotter, Frances
T1 - The Network for the Improvement of Addiction Treatment (NIATx): Enhancing access and retention.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2007/05//
VL - 88
IS - 2-3
SP - 138
EP - 145
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - McCarty, Dennis, Department of Public Health and Preventive Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, CB669, Portland, OR, US, 97239
N1 - Accession Number: 2007-05311-004. PMID: 17129680 Partial author list: First Author & Affiliation: McCarty, Dennis; Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, US. Release Date: 20070521. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Outpatient Treatment; Residential Care Institutions; Retention. Minor Descriptor: Evaluation; Outpatients. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Other Internet. References Available: Y. Page Count: 8. Issue Publication Date: May, 2007.
AB - The Network for the Improvement of Addiction Treatment (NIATx) teaches participating treatment centers to use process improvement strategies. A cross-site evaluation monitored impacts on days between first contact and first treatment and percent of patients who started treatment and completed two, three and four units of care (i.e., one outpatient session, 1 day of intensive outpatient care, and 1 week of residential treatment). The analysis included 13 agencies that began participation in August 2003, submitted 10-15 months of data, and attempted improvements in outpatient (n=7), intensive outpatient (n=4) or residential treatment services (n=4) (two agencies provided data for two levels of care). Days to treatment declined 37% (from 19.6 to 12.4 days) across levels of care; the change was significant overall and for outpatient and intensive outpatient services. Significant overall improvement in retention in care was observed for the second unit of care (72-85%; 18% increase) and the third unit of care (62-73%; 17% increase); when level of care was assessed, a significant gain was found only for intensive outpatient services. Small incremental changes in treatment processes can lead to significant reductions in days to treatment and consistent gains in retention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - addiction treatment
KW - residential treatment services
KW - retention
KW - outpatient services
KW - cross-site evaluation
KW - 2007
KW - Addiction
KW - Outpatient Treatment
KW - Residential Care Institutions
KW - Retention
KW - Evaluation
KW - Outpatients
KW - 2007
DO - 10.1016/j.drugalcdep.2006.10.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-05311-004&site=ehost-live&scope=site
UR - ORCID: 0000-0003-3441-946X
UR -
UR - mccartyd@ohsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07270-007
AN - 2007-07270-007
AU - Lando, Amy M.
AU - Labiner-Wolfe, Judith
T1 - Helping consumers make more healthful food choices: Consumer views on modifying food labels and providing point-of-purchase nutrition information at quick-service restaurants.
JF - Journal of Nutrition Education and Behavior
JO - Journal of Nutrition Education and Behavior
JA - J Nutr Educ Behav
Y1 - 2007/05//May-Jun, 2007
VL - 39
IS - 3
SP - 157
EP - 163
CY - Netherlands
PB - Elsevier Science
SN - 1499-4046
SN - 1878-2620
AD - Lando, Amy M., 5100 Paint Branch Parkway, College Park, MD, US, 20740
N1 - Accession Number: 2007-07270-007. PMID: 17493566 Other Journal Title: Journal of Nutrition Education. Partial author list: First Author & Affiliation: Lando, Amy M.; US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, US. Other Publishers: BC Decker. Release Date: 20070806. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Calories; Consumer Behavior; Eating Behavior; Health Knowledge; Nutrition. Minor Descriptor: Food. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May-Jun, 2007.
AB - Objectives: To understand consumer (1) interest in nutrition information on food labels and quick-service restaurant menu boards and (2) reactions to modifying this information to help highlight calories and more healthful choices. Design: Eight consumer focus groups, using a guide and stimuli. Setting: Focus group discussions in 4 US cities. Participants: A total of 68 consumers, with 7 to 10 per focus group. Analysis: Authors prepared detailed summaries of discussions based on observation. Video recordings and transcripts were used to cross-check summaries. Data were systematically reviewed, synthesized, and analyzed. Phenomenon of Interest: Consumer views on alternative presentations of nutrition information on packaged food items and quick-service restaurant menu boards. Results: Participants (1) were interested in having nutrition information available, but would not use it at every eating occasion; (2) thought that food products typically consumed at 1 eating occasion should be labeled as a single serving; and (3) indicated that an icon on labels and menu boards that signaled more healthful options could be helpful. Conclusions and Implications: Findings provide a basis for the development of more systematic studies to better understand whether alternative presentations of nutrition information would help consumers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - helping consumers
KW - healthful food choices
KW - consumer views
KW - food labels
KW - point of purchase nutrition information
KW - quick service restaurants
KW - 2007
KW - Calories
KW - Consumer Behavior
KW - Eating Behavior
KW - Health Knowledge
KW - Nutrition
KW - Food
KW - 2007
U1 - Sponsor: US Department of Health and Human Services, US. Recipients: No recipient indicated
DO - 10.1016/j.jneb.2006.12.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07270-007&site=ehost-live&scope=site
UR - amy.lando@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07581-006
AN - 2007-07581-006
AU - Zito, Julie M.
AU - Safer, Daniel J.
AU - Valluri, Satish
AU - Gardner, James F.
AU - Korelitz, James J.
AU - Mattison, Donald R.
T1 - Psychotherapeutic medication prevalence in Medicaid-insured preschoolers.
JF - Journal of Child and Adolescent Psychopharmacology
JO - Journal of Child and Adolescent Psychopharmacology
JA - J Child Adolesc Psychopharmacol
Y1 - 2007/05//
VL - 17
IS - 2
SP - 195
EP - 203
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1044-5463
SN - 1557-8992
AD - Zito, Julie M., University of Maryland, 220 Arch Street, Baltimore, MD, US, 21201
N1 - Accession Number: 2007-07581-006. PMID: 17489714 Partial author list: First Author & Affiliation: Zito, Julie M.; Department of Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore, MD, US. Release Date: 20070917. Correction Date: 20110620. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Health Insurance; International Classification of Diseases; Medicaid; Psychotherapeutic Processes. Minor Descriptor: Outpatients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2007.
AB - Objective: To update knowledge of the prevalence of the use of psychotherapeutic medications in preschoolers with Medicaid insurance as requested by the Best Pharmaceuticals for Children Act of 2002 (BPCA). Method: Prescription, enrollment, and outpatient visit data from 7 state Medicaid programs were used to identify 274,518 youths continuously enrolled in 2001 and aged 2 to 4 on January 1, 2001. Annual prevalence of use was defined as one or more dispensed prescriptions for a psychotherapeutic medication and adjusted for anticonvulsant and anxiolytic/sedative/hypnotic use according to ICD-9 diagnostic groupings. Prevalence ratios adjusted for age, race/ethnicity, and gender were estimated. Results: 2.30% (CI = 2.24, 2.36) of preschoolers received one or more dispensings for a psychotherapeutic medication in 2001, approximately doubling the usage of comparable youth from 2 other state Medicaid programs studied in 1995. Boys were 2.4 times more likely than girls to receive psychotherapeutic medication. Whites were 4 times more likely than Hispanics and twice as likely as Blacks to receive medication for psychiatric or behavioral conditions. Since the mid-1990s, usage increased, especially for atypical antipsychotics and antidepressants. The prominent use of anticonvulsants (78.8%) and anxiolytic/sedative/hypnotic drugs (91.4%) in those with no psychiatric diagnosis, but with other medical diagnoses, shows that much use therein reflects treatment for seizures, rather than mood stabilization, and for minor medical conditions, rather than psychiatric disorders. Conclusion: Preschool psychotherapeutic medication use increased across ages 2 to 4 for stimulants, antipsychotics, and antidepressants, reflecting use for psychiatric/behavioral disorders. However, the use of anxiolytic/sedative/hypnotics and anticonvulsants was more stable across these years, suggesting medical usage. Additional research to assess the benefits and risks of psychotherapeutic drugs is needed, particularly when such usage is off-label for both psychiatric and nonpsychiatric conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotherapeutic medication
KW - medicaid insured preschoolers
KW - health insurance
KW - 2007
KW - Drug Therapy
KW - Health Insurance
KW - International Classification of Diseases
KW - Medicaid
KW - Psychotherapeutic Processes
KW - Outpatients
KW - 2007
U1 - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Recipients: No recipient indicated
DO - 10.1089/cap.2007.0006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07581-006&site=ehost-live&scope=site
UR - ORCID: 0000-0001-5623-0874
UR -
UR - jzito@rx.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-07772-011
AN - 2008-07772-011
AU - De Loore, Ellen
AU - Drukker, Marjan
AU - Gunther, Nicole
AU - Feron, Frans
AU - Deboutte, Dirk
AU - Sabbe, Bernard
AU - Mengelers, Ron
AU - van Os, Jim
AU - Myin-Germeys, Inez
T1 - Childhood negative experiences and subclinical psychosis in adolescence: A longitudinal general population study.
JF - Early Intervention in Psychiatry
JO - Early Intervention in Psychiatry
Y1 - 2007/05//
VL - 1
IS - 2
SP - 201
EP - 207
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1751-7885
SN - 1751-7893
AD - Myin-Germeys, Inez, Department of Psychiatry and Neuropsychology, Maastricht University, PO Box 616 (VIJV), 6200, Maastricht, Netherlands
N1 - Accession Number: 2008-07772-011. Partial author list: First Author & Affiliation: De Loore, Ellen; Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, Netherlands. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Myin-Germeys, Inez. Major Descriptor: Adolescent Psychopathology; Life Experiences; Psychosis; Risk Factors; Bullying. Classification: Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Tests & Measures: Diagnostic Interview Schedule for Children. Methodology: Empirical Study; Followup Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May, 2007.
AB - Background: Accumulating evidence suggests that experiences of trauma and victimization during childhood are associated with an increased risk to develop clinical and subclinical psychosis in adulthood. A recent cross-sectional study showed a significant association between trauma and psychotic experiences in adolescents. The current study aimed to extend these findings by investigating the longitudinal effects of negative life experiences on the risk for subclinical psychotic symptoms 2 years later in an adolescent general community sample. Methods: Data were derived from the standard health screenings of the Youth Health Care Divisions of the Public Health Services, in the South of the Netherlands. A total of 1129 adolescents filled out a self-report questionnaire at age 13/14 years and 2 years later (15/16 years), assessing psychotic experiences, as well as experiences of being bullied, sexual trauma, and negative life events. Results: Logistic regression analyses revealed that sexual trauma increased the risk for psychotic symptoms 2 years later. Life events contributed to the risk for psychosis over time and psychosis in turn gave rise to new life events. No significant association with bullying was found after controlling for confounders. Conclusion: The results provide further evidence for an association between childhood environment and psychosis in the crucial developmental period of early adolescence. Early and later psychological stress, if severe, may impact on the risk for psychosis in adolescence through mechanisms of person-environment interaction and correlation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - childhood negative experiences
KW - subclinical psychosis
KW - adolescence
KW - bullying
KW - risk factors
KW - 2007
KW - Adolescent Psychopathology
KW - Life Experiences
KW - Psychosis
KW - Risk Factors
KW - Bullying
KW - 2007
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Date: from 2006. Other Details: Young Investigator Award. Recipients: Myin-Germeys, Inez
U1 - Sponsor: Medical Research Council, Netherlands. Other Details: VIDI grant. Recipients: No recipient indicated
DO - 10.1111/j.1751-7893.2007.00027.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07772-011&site=ehost-live&scope=site
UR - i.germeys@sp.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07785-010
AN - 2007-07785-010
AU - Mrazek, Patricia J.
AU - Ritchie, Gail F.
T1 - Becoming a preventionist.
JF - Psychiatric Annals
JO - Psychiatric Annals
JA - Psychiatr Ann
Y1 - 2007/05//
VL - 37
IS - 5
SP - 365
EP - 370
CY - US
PB - SLACK
SN - 0048-5713
SN - 1938-2456
AD - Mrazek, Patricia J., 3443 Wright Road, SW, Rochester, MN, US, 55902
N1 - Accession Number: 2007-07785-010. Partial author list: First Author & Affiliation: Mrazek, Patricia J.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Release Date: 20070709. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: At Risk Populations; Intervention; Primary Mental Health Prevention; Psychiatry. Minor Descriptor: Behavior Disorders; Mental Disorders; Psychiatric Evaluation; Psychiatric Patients. Classification: Health Psychology & Medicine (3360). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: May, 2007.
AB - The clinical practice of tomorrow already is being reshaped. Prevention will be as much a part of practice as treatment is now. Prevention practice will be based on exciting new scientific developments, such as new methods for identifying at-risk people, new empirically based interventions delivered in a variety of settings, innovative methods of engaging people and communities, and new outcome evaluation strategies. Becoming a preventionist enables a clinician to take measures in advance to guard against the possible or probable first onset of mental and behavioral disorders in patients and their family members. This overview, excerpted from a monograph prepared for the Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, provides practicing psychiatrists with a six-step approach to incorporating prevention into clinical practice. The steps outlined below are suggestions, not dogma. The ways of becoming a preventionist cannot be followed like a cookbook, but the six steps provided, which are not necessarily sequential, represent a pedagogical vehicle for incorporating prevention into general psychiatric practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - practicing psychiatrists
KW - prevention
KW - clinical practice
KW - at-risk people
KW - interventions
KW - evaluation strategies
KW - mental & behavioral disorders
KW - patients
KW - family members
KW - 2007
KW - At Risk Populations
KW - Intervention
KW - Primary Mental Health Prevention
KW - Psychiatry
KW - Behavior Disorders
KW - Mental Disorders
KW - Psychiatric Evaluation
KW - Psychiatric Patients
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07785-010&site=ehost-live&scope=site
UR - pjmrazek@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07104-007
AN - 2007-07104-007
AU - Ridenour, Marilyn L.
AU - Cummings, Kristin J.
AU - Sinclair, Julie R.
AU - Bixler, Danae
T1 - Displacement of the underserved: Medical needs of Hurricane Katrina evacuees in West Virginia.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/05//
VL - 18
IS - 2
SP - 369
EP - 381
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Ridenour, Marilyn L., NIOSH, Division of Safety Research, 1095 Willowdale Rd., Mailstop 1811, Morgantown, WV, US, 26505
N1 - Accession Number: 2007-07104-007. PMID: 17483565 Partial author list: First Author & Affiliation: Ridenour, Marilyn L.; Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Safety Research (DSR), Morgantown, WV, US. Release Date: 20070924. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emergency Services; Natural Disasters; Needs Assessment; Shelters. Minor Descriptor: Chronic Illness; Dental Treatment; Food; Hygiene. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. Page Count: 13. Issue Publication Date: May, 2007.
AB - On August 29, 2005 Hurricane Katrina struck Louisiana, Mississippi, and Alabama. During the aftermath of the storm, hurricane victims were evacuated to over 1,000 evacuation centers in 27 states. Three-hundred and twenty-three evacuees from 220 households were provided housing, food, and medical care at an evacuation center in West Virginia. A needs assessment followed to identify current needs of the evacuees. One-hundred and sixty-four evacuees were interviewed. Twenty-five percent reported an acute illness, while 46% reported having at least one chronic medical condition. The greatest need reported was for dental care (57%), followed by eyeglasses (34%), dentures (28%), and medical services (25%). Two weeks after the hurricane, the basic needs of food, shelter, and hygiene were met. The assessment identified and led to a successful response regarding the ongoing need for durable medical equipment (dentures and eyeglasses), as well as dental care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - displacement
KW - medical needs
KW - hurricane Katrina evacuees
KW - hurricane victims
KW - medical equipment
KW - 2007
KW - Emergency Services
KW - Natural Disasters
KW - Needs Assessment
KW - Shelters
KW - Chronic Illness
KW - Dental Treatment
KW - Food
KW - Hygiene
KW - 2007
DO - 10.1353/hpu.2007.0045
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07104-007&site=ehost-live&scope=site
UR - DVN7@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06347-010
AN - 2007-06347-010
AU - McInnes, D. Keith
AU - Landon, Bruce E.
AU - Wilson, Ira B.
AU - Hirschhorn, Lisa R.
AU - Marsden, Peter V.
AU - Malitz, Faye
AU - Barini-Garcia, Magda
AU - Cleary, Paul D.
T1 - The impact of a quality improvement program on systems, processes, and structures in medical clinics.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2007/05//
VL - 45
IS - 5
SP - 463
EP - 471
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - McInnes, D. Keith, Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, US, 02115
N1 - Accession Number: 2007-06347-010. PMID: 17446833 Partial author list: First Author & Affiliation: McInnes, D. Keith; Department of Health Care Policy, Division of General Medicine, Harvard Medical School, Boston, MA, US. Release Date: 20070702. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinicians; Clinics; Health Care Services; HIV; Quality of Care. Minor Descriptor: Outpatients; Health Personnel. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2007.
AB - Objective: We sought to assess whether participation in a quality-improvement collaborative changed care processes, systems, and organization of outpatient human immunodeficiency virus (HIV) clinics. Methods: We surveyed clinicians, medical directors, and HIV program administrators before and after an 18-month quality improvement collaborative at 54 intervention and 37 control clinics providing HIV care. Surveys assessed clinic structures, processes, systems, and culture. During the collaborative, a clinician-administrator team from each intervention clinic attended 4 2-day sessions on quality improvement techniques. Conference calls, a website, and an e-mail list provided support and facilitated communication among collaborative participants. Results: Survey response rates were 85% or greater. Six of 54 organizational measures differed significantly between baseline and follow-up. Intervention clinicians reported greater computer availability (82% vs. 67%, P = 0.03) and use (3.13 vs. 2.68, P = 0.02; 4-point scale), attended more local (14.2 vs. 8.6, P < 0.01) and national (4.1 vs. 2.9, P = 0.01) conferences, and rated leaders' ability to implement quality improvement higher (3.8 vs. 3.4, P = 0.01; 5-point scale). Intervention directors were more likely to compare quality data to other clinics (79% vs. 54%, P = 0.04). For the set of 54 measures, intervention clinics were more likely to have higher post-intervention scores than controls (sign test, mean = 14.5, P < 0.0001). Conclusions: A quality-improvement collaborative for HIV clinics resulted in modest organizational changes. Achieving greater change may require more focused and/or intensive interventions, greater resources for participating clinics, and better developed information technology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality improvement program
KW - medical clinics
KW - outpatient human immunodeficiency virus clinics
KW - 2007
KW - Clinicians
KW - Clinics
KW - Health Care Services
KW - HIV
KW - Quality of Care
KW - Outpatients
KW - Health Personnel
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: R-01HS10227. Recipients: No recipient indicated
DO - 10.1097/01.mlr.0000256965.94471.c2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06347-010&site=ehost-live&scope=site
UR - ORCID: 0000-0002-0246-738X
UR -
UR - mcinnes@hcp.med.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12358-025
AN - 2007-12358-025
AU - Power, A. Kathryn
AU - del Vecchio, Paolo
T1 - Consumer-directed behavioral health care.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/05//
VL - 58
IS - 5
SP - 714
EP - 714
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2007-12358-025. PMID: 17463360 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Power, A. Kathryn; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20080107. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Behavior Modification; Client Centered Therapy; Health Care Costs. Minor Descriptor: Decision Making. Classification: Psychotherapy & Psychotherapeutic Counseling (3310). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: May, 2007.
AB - Letter to editor comments on an article 'Implementation of a Consumer-Directed Approach in Behavioral Health Care: Problems and Prospects,' by R. A. LaBrie et al (see record [rid]2007-07343-014[/rid]). Discusses several important barriers in realizing the potential of consumer-directed behavioral health care. As described by LaBrie et al, health savings accounts (HSAs) typically use the high-deductible approaches in private insurance markets. We agree that consumers require comprehensive information on quality as well as costs in order to fully utilize consumer-directed care approaches. We do question the LaBrie et al characterization that mental health consumers lack adequate decision-making and self-care abilities to fully utilize consumer-directed care approaches. Consumer direction holds great promise in transforming how mental health services are delivered. Such approaches, in which consumers' self-identified needs, preferences, and choices are the principal drivers, will help us reach our shared destination-recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consumer directed approach implementation
KW - behavioral health care
KW - health care costs
KW - 2007
KW - Behavior Modification
KW - Client Centered Therapy
KW - Health Care Costs
KW - Decision Making
KW - 2007
DO - 10.1176/appi.ps.58.5.714
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12358-025&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06219-023
AN - 2007-06219-023
AU - Tunbridge, E. M.
AU - Weickert, C. S.
AU - Kleinman, J. E.
AU - Herman, M. M.
AU - Chen, J.
AU - Kolachana, B. S.
AU - Harrison, P. J.
AU - Weinberger, D. R.
T1 - Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan.
JF - Cerebral Cortex
JO - Cerebral Cortex
JA - Cereb Cortex
Y1 - 2007/05//
VL - 17
IS - 5
SP - 1206
EP - 1212
CY - United Kingdom
PB - Oxford University Press
SN - 1047-3211
SN - 1460-2199
AD - Tunbridge, E. M., Department of Psychiatry, Oxford University, Warneford Hospital, Neurosciences Building, Oxford, United Kingdom, OX3 7JX
N1 - Accession Number: 2007-06219-023. PMID: 16835293 Partial author list: First Author & Affiliation: Tunbridge, E. M.; Department of Psychiatry, University of Oxford, Oxford, United Kingdom. Release Date: 20070702. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Weickert, C. S. Major Descriptor: Dopamine; Life Span; Postnatal Period; Prefrontal Cortex; Transferases. Minor Descriptor: Enzymes; Proteins. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May, 2007.
AB - The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates. Catechol-o-methyltransferase (COMT) alters extracellular dopamine levels in PFC, and its gene contains a functional polymorphism (Val¹⁵⁸Met) that has been associated with variation in PFC function. We examined COMT enzyme activity and protein immunoreactivity in the PFC during human postnatal development. Protein was extracted from PFC of normal individuals from 6 age groups: neonates (1-4 months), infants (5-11 months), teens (14-18 years), young adults (20-24 years), adults (31-43 years), and aged individuals (68-86 years; n = 5-8 per group). There was a significant 2-fold increase in COMT enzyme activity from neonate to adulthood, paralleled by increases in COMT protein immunoreactivity. Furthermore, COMT protein immunoreactivity was related to Val¹⁵⁸Met genotype, as has been previously demonstrated. The significant increase in COMT activity from neonate to adulthood complements previous findings of protracted postnatal changes in the PFC dopamine system and may reflect an increasing importance of COMT for PFC dopamine regulation during maturation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - catechol-o-methyltransferase enzyme
KW - postnatal lifespan
KW - protein expression
KW - prefrontal cortex
KW - dopamine
KW - 2007
KW - Dopamine
KW - Life Span
KW - Postnatal Period
KW - Prefrontal Cortex
KW - Transferases
KW - Enzymes
KW - Proteins
KW - 2007
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program. Other Details: Intramural Research Program. Recipients: Weickert, C. S.; Kleinman, J. E.; Herman, M. M.; Chen, J.; Kolachana, B. S.; Weinberger, D. R.
U1 - Sponsor: Medical Research Council. Recipients: Harrison, P. J.
U1 - Sponsor: Stanley Medical Research Institute. Recipients: Harrison, P. J.
DO - 10.1093/cercor/bhl032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06219-023&site=ehost-live&scope=site
UR - elizabeth.tunbridge@psych.ox.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09329-001
AN - 2007-09329-001
AU - Zarin, Deborah A.
AU - Ide, Nicholas C.
AU - Tse, Tony
AU - Harlan, William R.
AU - West, Joyce C.
AU - Lindberg, Donald A. B.
T1 - Issues in the registration of clinical trials.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2007/05//
VL - 297
IS - 19
SP - 2112
EP - 2120
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
AD - Zarin, Deborah A., ClinicalTrials.gov, National Library of Medicine, 8600 Rockville Pike, Bldg 38A, Room 75705, Rockville, MD, US, 20894
N1 - Accession Number: 2007-09329-001. PMID: 17507347 Partial author list: First Author & Affiliation: Zarin, Deborah A.; National Library of Medicine (NLM), National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20070924. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Databases; Information Dissemination; Treatment Guidelines; Health Care Policy. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). References Available: Y. Page Count: 9. Issue Publication Date: May, 2007.
AB - Public concerns about the perils associated with incomplete or delayed reporting of results from clinical trials has heightened interest in trial registries and results databases. Here we review the current status of trial registration efforts and the challenges in developing a comprehensive system of trial registration and reporting of results. ClinicalTrials.gov, the largest trial registry with 36249 trials from approximately 140 countries, has procedures in place to help ensure that records are valid and informative. Key challenges include the need to minimize inadvertent duplicate registrations, to ensure that interventions have unambiguous names, and to have a search engine that identifies all trials that meet a user's specifications. Recent policy initiatives have called for the development of a database of trial results. Several issues confound the implementation of such a database, including the lack of an accepted format or process for providing summaries of trial results to the public and concerns about disseminating data in the absence of independent scientific review. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical trials
KW - registration issues
KW - policy making
KW - databases
KW - information dissemination
KW - 2007
KW - Clinical Trials
KW - Databases
KW - Information Dissemination
KW - Treatment Guidelines
KW - Health Care Policy
KW - 2007
U1 - Sponsor: National Institutes of Health, National Library of Medicine, Intramural Research Program, US. Recipients: No recipient indicated
DO - 10.1001/jama.297.19.2112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09329-001&site=ehost-live&scope=site
UR - dzarin@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07068-021
AN - 2007-07068-021
AU - Roedig, Erich
T1 - German perspective: Commentary on 'Recommendations for the ethical use of pharmacologic fatigue countermeasures in the U.S. military.'
T3 - Operational applications of cognitive performance enhancement technologies
JF - Aviation, Space, and Environmental Medicine
JO - Aviation, Space, and Environmental Medicine
JA - Aviat Space Environ Med
Y1 - 2007/05//
VL - 78
IS - 5, Sect II, Suppl
SP - B136
EP - B137
CY - US
PB - Aerospace Medical Assn
SN - 0095-6562
AD - Roedig, Erich, Surgeon General, German Air Forces, Bruckberg-Kaserne, Luisenstr. 109, D-53721, Siegburg, Germany
N1 - Accession Number: 2007-07068-021. Other Journal Title: Aerospace Medicine; Aerospace Medicine and Human Performance. Partial author list: First Author & Affiliation: Roedig, Erich; Office of the Surgeon General, German Air Forces, Siegburg, Germany. Release Date: 20071029. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Bioethics; Cognitive Ability; Group Performance; Military Personnel; Pharmacology. Minor Descriptor: War. Classification: Military Psychology (3800). Population: Human (10). Page Count: 2. Issue Publication Date: May, 2007.
AB - Comments on an article by Michael B. Russo (see record [rid]2007-07068-017[/rid]). The human rules and values of our common western democratic society must be obeyed in context with legal and ethical aspects, as well as in an operational military environment. Even though there may be particular exceptional circumstances, the forced use of cogniceuticals is contrary to our values, and also contrary to effective cross-cultural considerations in a multinational battlefield. It is very problematic to define methods for studies to evaluate the efficiency and safety of cogniceuticals in complex and extreme operational situations. It is not clear whether a cumulative use/self-medication will have significant impact on cognitive performance and personality. The long-term effects may not be foreseen. An important aspect you mentioned is that application of a cogniceutical agent to restore function is not enhancement but rather sustainment within a homeostatic balance. As flight surgeons and medical officers, it is our special obligation to provide the best medical service for the welfare of our aircrew and soldiers during all phases of missions and deployments. Applying pharmacological agents is unjustifiable due to ethical and moral reasons, especially when it has been tried in the past, in an apparently voluntary nature. The German position is that only caffeine, with its high therapeutic index, is acceptable to maintain sustainability in an operational environment. Other enhancing drugs are strictly forbidden and also not approved by Federal authorities as medications for this indication. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - recommendations
KW - ethical use
KW - pharmacologic fatigue countermeasures
KW - military
KW - cognitive performance enhancement technologies
KW - 2007
KW - Bioethics
KW - Cognitive Ability
KW - Group Performance
KW - Military Personnel
KW - Pharmacology
KW - War
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07068-021&site=ehost-live&scope=site
UR - erichroedig@bundeswehr.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Punch, J. D.
AU - Hayes, D. H.
AU - LaPorte, F. B.
AU - McBride, V.
AU - Seely, M. S.
T1 - Organ Donation and Utilization in the United States, 1996–2005.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2007/05/02/May2007 Supplement
VL - 7
M3 - Article
SP - 1327
EP - 1338
PB - Wiley-Blackwell
SN - 16006135
AB - The success of clinical transplantation as a therapy for end-stage organ failure is limited by the availability of suitable organs for transplant. This article discusses continued efforts by the transplant community to collaboratively improve the organ supply. There were 7593 deceased organ donors in 2005. This represents an all-time high and a 6% increase over 2004. Increases were noted in deceased organ donation of all types of organs; notable is the increase in lung donation, which occurred in 17% of all deceased donors. The percentage of deceased donations that occurred following cardiac death has also reached a new high at 7%. The number of living donors decreased by 2%, from 7003 in 2004 to 6895 in 2005. This article discusses the continued efforts of the Organ Donation Breakthrough Collaborative and the Organ Transplantation Breakthrough Collaborative to support organ recovery and use and to encourage the expectation that for every deceased donor, all organs will be placed and transplanted. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DONATION of organs, tissues, etc.
KW - THERAPEUTICS
KW - MULTIPLE organ failure
KW - DEATH
KW - Deceased donors
KW - donors
KW - donors after cardiac death
KW - living donors
KW - OPTN
KW - Organ Donation Breakthrough Collaborative
KW - SRTR
N1 - Accession Number: 24669619; Punch, J. D. 1; Email Address: jpunch@med.umich.edu Hayes, D. H. 2 LaPorte, F. B. 3 McBride, V. 4 Seely, M. S. 5; Affiliation: 1: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA 2: LifeShare of the Carolinas, Charlotte, North Carolina, USA 3: Scientific Registry of Transplant Recipients (SRTR), Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA 4: Department of Health and Human Services, Health Resources and Services Administration, Rockville, Maryland, USA 5: Pacific Northwest Transplant Bank, Oregon Health & Science University, Portland, Oregon, USA; Source Info: May2007 Supplement, Vol. 7, p1327; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DONATION of organs, tissues, etc.; Subject Term: THERAPEUTICS; Subject Term: MULTIPLE organ failure; Subject Term: DEATH; Author-Supplied Keyword: Deceased donors; Author-Supplied Keyword: donors; Author-Supplied Keyword: donors after cardiac death; Author-Supplied Keyword: living donors; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: Organ Donation Breakthrough Collaborative; Author-Supplied Keyword: SRTR; Number of Pages: 12p; Illustrations: 6 Graphs, 1 Map; Document Type: Article
L3 - 10.1111/j.1600-6143.2007.01779.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24669619&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolfe, R. A.
AU - LaPorte, F. B.
AU - Rodgers, A. M.
AU - Roys, E. C.
AU - Fant, G.
AU - Leichtman, A. B.
T1 - Developing Organ Offer and Acceptance Measures: When ‘Good’ Organs Are Turned Down.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2007/05/02/May2007 Supplement
VL - 7
M3 - Article
SP - 1404
EP - 1411
PB - Wiley-Blackwell
SN - 16006135
AB - Turndowns of offers of deceased donor kidneys for transplantation can contribute to inefficiencies in the organ distribution system and inequality in access to donated organs. Match run data were obtained for 4967 ‘good’ kidneys placed and transplanted in 2005 after fewer than 50 offers. These kidneys were not recovered from donation after cardiac death or expanded criteria donors, or from donors with a history of substance abuse. On average, these good kidneys were not accepted until after seven offers to candidates and after offers to 2.4 programs. Models for the likelihood of acceptance found several donor and candidate characteristics to be significantly related to acceptance rates (p < 0.05). After accounting for these variables, there remained 2- to 3-fold differences among transplant programs in acceptance rates. These models could be used to identify kidney transplant centers with exceptional acceptance practices. Several strategies might be employed to increase acceptance rates for good organs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KIDNEY transplants
KW - DONATION of organs, tissues, etc.
KW - SUBSTANCE abuse
KW - TRANSPLANTATION of organs, tissues, etc.
KW - ALLOCATION of organs, tissues, etc.
KW - Acceptance rates
KW - graft survival
KW - kidney transplantation
KW - methodology
KW - OPTN
KW - organ offers
KW - SRTR
N1 - Accession Number: 24669614; Wolfe, R. A. 1; Email Address: Robert.Wolfe@ArborResearch.org LaPorte, F. B. 1 Rodgers, A. M. 1 Roys, E. C. 1 Fant, G. 2 Leichtman, A. B. 3; Affiliation: 1: Scientific Registry of Transplant Recipients, Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA 2: Division of Transplantation, Healthcare Systems Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland, USA 3: Scientific Registry of Transplant Recipients, University of Michigan, Ann Arbor, Michigan, USA; Source Info: May2007 Supplement, Vol. 7, p1404; Subject Term: KIDNEY transplants; Subject Term: DONATION of organs, tissues, etc.; Subject Term: SUBSTANCE abuse; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: ALLOCATION of organs, tissues, etc.; Author-Supplied Keyword: Acceptance rates; Author-Supplied Keyword: graft survival; Author-Supplied Keyword: kidney transplantation; Author-Supplied Keyword: methodology; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: organ offers; Author-Supplied Keyword: SRTR; Number of Pages: 8p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2007.01784.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24669614&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ashby, V. B.
AU - Kalbfleisch, J. D.
AU - Wolfe, R. A.
AU - Lin, M. J.
AU - Port, F. K.
AU - Leichtman, A. B.
T1 - Geographic Variability in Access to Primary Kidney Transplantation in the United States, 1996–2005.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2007/05/02/May2007 Supplement
VL - 7
M3 - Article
SP - 1412
EP - 1423
PB - Wiley-Blackwell
SN - 16006135
AB - This article focuses on geographic variability in patient access to kidney transplantation in the United States. It examines geographic differences and trends in access rates to kidney transplantation, in the component rates of wait-listing, and of living and deceased donor transplantation. Using data from Centers for Medicare and Medicaid Services and the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients, we studied 700 000+ patients under 75, who began chronic dialysis treatment, received their first living donor kidney transplant, or were placed on the waiting list pre-emptively. Relative rates of wait-listing and transplantation by State were calculated using Cox regression models, adjusted for patient demographics. There were geographic differences in access to the kidney waiting list and to a kidney transplant. Adjusted wait-list rates ranged from 37% lower to 64% higher than the national average. The living donor rate ranged from 57% lower to 166% higher, while the deceased donor transplant rate ranged from 60% lower to 150% higher than the national average. In general, States with higher wait-listing rates tended to have lower transplantation rates and States with lower wait-listing rates had higher transplant rates. Six States demonstrated both high wait-listing and deceased donor transplantation rates while six others, plus D.C. and Puerto Rico, were below the national average for both parameters. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DONATION of organs, tissues, etc.
KW - KIDNEY transplants
KW - DIALYSIS (Chemistry)
KW - MEDICARE
KW - PATIENTS
KW - UNITED States
KW - Access rates
KW - deceased donor rates
KW - living donor rates
KW - OPTN
KW - SRTR
KW - wait-listing
N1 - Accession Number: 24669613; Ashby, V. B. 1; Email Address: valarieb@umich.edu Kalbfleisch, J. D. 2 Wolfe, R. A. 3 Lin, M. J. 4 Port, F. K. 3 Leichtman, A. B. 1; Affiliation: 1: University of Michigan, SRTR, Ann Arbor, Michigan, USA 2: University of Michigan, Biostatistics, Ann Arbor, Michigan, USA 3: Arbor Research Collaborative for Health, SRTR, Ann Arbor, Michigan, USA 4: Health Resources and Services Administration, Rockville, Maryland, USA; Source Info: May2007 Supplement, Vol. 7, p1412; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DONATION of organs, tissues, etc.; Subject Term: KIDNEY transplants; Subject Term: DIALYSIS (Chemistry); Subject Term: MEDICARE; Subject Term: PATIENTS; Subject Term: UNITED States; Author-Supplied Keyword: Access rates; Author-Supplied Keyword: deceased donor rates; Author-Supplied Keyword: living donor rates; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: wait-listing; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 12p; Illustrations: 9 Maps; Document Type: Article
L3 - 10.1111/j.1600-6143.2007.01785.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24669613&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kresina, Thomas F.
AU - Hoffman, Kenneth
AU - Lubran, Robert
AU - Clark, H. Westley
T1 - Integrating Hepatitis Services into Substance Abuse Treatment Programs: New Initiatives from SAMHSA.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007/05/02/May/Jun2007 Supplement
VL - 122
M3 - Article
SP - 96
EP - 98
SN - 00333549
AB - The article reports on a number of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and viral hepatitis prevention and control activities undertaken by the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA). It says that the activities include ensuring that HIV/AIDS and viral hepatitis are a significant focus in SAMHSA grant programs, as appropriate, increasing the number of SAMHSA grantees that provide HIV testing, among others.
KW - HIV (Viruses)
KW - PREVENTION
KW - AIDS (Disease) -- Prevention
KW - VIRAL hepatitis
KW - UNITED States
KW - UNITED States. Substance Abuse & Mental Health Services Administration
N1 - Accession Number: 24833655; Kresina, Thomas F. 1; Email Address: Thomas.Kresina@samhsa.hhs.gov Hoffman, Kenneth 1 Lubran, Robert 1 Clark, H. Westley 2; Affiliation: 1: Division for Pharmacologic Therapies, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD 2: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: May/Jun2007 Supplement, Vol. 122, p96; Subject Term: HIV (Viruses); Subject Term: PREVENTION; Subject Term: AIDS (Disease) -- Prevention; Subject Term: VIRAL hepatitis; Subject Term: UNITED States; Company/Entity: UNITED States. Substance Abuse & Mental Health Services Administration; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106152705
T1 - Integrating hepatitis services into substance abuse treatment programs: new initiatives from SAMHSA.
AU - Kresina TF
AU - Hoffman K
AU - Lubran R
AU - Clark HW
Y1 - 2007/05/02/May/Jun2007 Supplement
N1 - Accession Number: 106152705. Language: English. Entry Date: 20070914. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: May/Jun2007 Supplement. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Hepatitis -- Prevention and Control
KW - Hepatitis -- Therapy
KW - HIV Infections -- Prevention and Control
KW - HIV Infections -- Therapy
KW - Substance Abuse, Intravenous -- Therapy
KW - Counseling
KW - Patient Education
KW - Public Health
SP - 96
EP - 98
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 122
PB - Sage Publications Inc.
SN - 0033-3549
AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Rockville, MD 20857
U2 - PMID: 17542463.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Padavattan, Sivaraman
AU - Schirmer, Tilman
AU - Schmidt, Margit
AU - Akdis, Cezmi
AU - Valenta, Rudolf
AU - Mittermann, Irene
AU - Soldatova, Lyudmila
AU - Slater, Jay
AU - Mueller, Ulrich
AU - Markovic-Housley, Zora
T1 - Identification of a B-cell Epitope of Hyaluronidase, a Major Bee Venom Allergen, from its Crystal Structure in Complex with a Specific Fab
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
Y1 - 2007/05/04/
VL - 368
IS - 3
M3 - Article
SP - 742
EP - 752
SN - 00222836
AB - Abstract: The major allergens of honeybee venom, hyaluronidase (Hyal) and phospholipase A2, can induce life-threatening IgE-mediated allergic reactions in humans. Although conventional immunotherapy is effective, up to 40% of patients develop allergic side effects including anaphylaxis and thus, there is a need for an improved immunotherapy. A murine monoclonal anti-Hyal IgG1 antibody (mAb 21E11), that competed for Hyal binding with IgEs from sera of bee venom allergic patients, was raised. The fragment of these IgG antibodies which bind to antigen (Fab) was produced and complexed (1:1) with Hyal. The crystal structure determination of Hyal/Fab 21E11 complex (2.6 Å) enabled the identification of the Hyal–IgG interface which provides indirect information on the Hyal–IgE interaction (B-cell epitope). The epitope is composed of a linear array of nine residues (Arg138, His141–Arg148) located at the tip of a helix–turn–helix motive which protrudes away from the globular core and fits tightly into the deep surface pocket formed by the residues from the six complementarity determining regions (CDRs) of the Fab. The epitope is continuous and yet its conformation appears to be essential for Ab recognition, since the synthetic 15-mer peptide comprising the entire epitope (Arg138–Glu152) is neither recognized by mAb 21E11 nor by human IgEs. The structure of the complex provides the basis for the rational design of Hyal derivatives with reduced allergenic activity, which could be used in the development of safer allergen-specific immunotherapy. [Copyright &y& Elsevier]
AB - Copyright of Journal of Molecular Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - IMMUNOGLOBULIN G
KW - MOLECULAR cloning
KW - POLYETHYLENE glycol
KW - antibody ( Ab )
KW - antigen ( Ag )
KW - B-cell epitope
KW - bee venom allergen
KW - complementarity determining region ( CDR )
KW - fragment of IgG which binds to antigen ( Fab )
KW - frame work region ( FWR )
KW - hyaluronidase
KW - hyaluronidase ( Hyal (or rApi m 2) )
KW - hyaluronidase/Fab complex
KW - immunoglobulin E ( IgE )
KW - molecular replacement ( MR )
KW - monoclonal antibody ( mAb )
KW - PBS/0.05% v/v Tween 20 ( PBST )
KW - phosphate-buffered saline ( PBS )
KW - polyethylene glycol ( PEG )
KW - specific immunotherapy ( SIT )
KW - Swiss Light Source ( SLS )
KW - X-ray structure
N1 - Accession Number: 24609854; Padavattan, Sivaraman 1 Schirmer, Tilman 1 Schmidt, Margit 2 Akdis, Cezmi 3 Valenta, Rudolf 4 Mittermann, Irene 4 Soldatova, Lyudmila 5 Slater, Jay 6 Mueller, Ulrich 7 Markovic-Housley, Zora 1; Email Address: zora.housley@unibas.ch; Affiliation: 1: Division of Structural Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland 2: Department of Biology, East Caroline University, Greenville, NC 27858, USA 3: Department of Cellular Allergology/Immunology, Swiss Institute of Allergy and Asthma Research, CH-7270, Davos, Switzerland 4: Christian Doppler Laboratory of Allergy Research, Division of Immunopathology, Department of Pathophysiology, Medical University of Vienna, A-1090 Vienna, Austria 5: OPS/ONDQA, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA 6: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA 7: SpitalBern, CH-3001 Bern, Switzerland; Source Info: May2007, Vol. 368 Issue 3, p742; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOGLOBULIN G; Subject Term: MOLECULAR cloning; Subject Term: POLYETHYLENE glycol; Author-Supplied Keyword: antibody ( Ab ); Author-Supplied Keyword: antigen ( Ag ); Author-Supplied Keyword: B-cell epitope; Author-Supplied Keyword: bee venom allergen; Author-Supplied Keyword: complementarity determining region ( CDR ); Author-Supplied Keyword: fragment of IgG which binds to antigen ( Fab ); Author-Supplied Keyword: frame work region ( FWR ); Author-Supplied Keyword: hyaluronidase; Author-Supplied Keyword: hyaluronidase ( Hyal (or rApi m 2) ); Author-Supplied Keyword: hyaluronidase/Fab complex; Author-Supplied Keyword: immunoglobulin E ( IgE ); Author-Supplied Keyword: molecular replacement ( MR ); Author-Supplied Keyword: monoclonal antibody ( mAb ); Author-Supplied Keyword: PBS/0.05% v/v Tween 20 ( PBST ); Author-Supplied Keyword: phosphate-buffered saline ( PBS ); Author-Supplied Keyword: polyethylene glycol ( PEG ); Author-Supplied Keyword: specific immunotherapy ( SIT ); Author-Supplied Keyword: Swiss Light Source ( SLS ); Author-Supplied Keyword: X-ray structure; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jmb.2007.02.036
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore, David F.
AU - Gelderman, Monique P.
AU - Ferreira, Paulo A.
AU - Fuhrmann, Steven R.
AU - Haiqing Yi
AU - Elkahloun, Abdel
AU - Lix, Lisa M.
AU - Brady, Roscoe O.
AU - Schiffmann, Raphael
AU - Goldin, Ehud
T1 - Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/05/08/
VL - 104
IS - 19
M3 - Article
SP - 8065
EP - 8070
SN - 00278424
AB - Fabry disease is a disorder of α-ᴅ-galactosyl-containing glycolipids resulting from a deficiency of α-galactosidase A. Patients have a poorly understood vascular dysregulation. We hypothesized that disease-related perturbation by using enzyme replacement therapy in the murine model of Fabry disease would provide insight into abnormal biological processes in Fabry disease. Gene expression analyses of the heart, aorta, and liver of male α-galactosidase A knockout mice 28 weeks of age were compared with that of WT mice. Microarray analyses were performed before and after six weekly injections of α-galactosidase A. Alteration of Rpgrip1 ranked highest statistically in all three organs when knockout mice were compared with WT, and its splice variants responded in a unique way to α-galactosidase A. Enzyme replacement therapy tended to not only normalize gene expression, e.g., reduce the overexpression of securin, but also specifically modified gene expression in each tissue examined. Following multiple comparison analysis, gene expression correlation graphs were constructed, and a priori hypotheses were examined by using structural equation modeling. This systems biology approach demonstrated multiple and complex parallel cellular abnormalities in Fabry disease. These abnormalities form the basis for informed, in a Bayesian sense, sequential, hypothesis-driven research that can be subsequently tested experimentally. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENOMICS
KW - METABOLIC disorders
KW - GENETIC disorders
KW - GLYCOSPHINGOLIPIDS
KW - GENE expression
KW - GROWTH factors
KW - SUPEROXIDE dismutase
KW - glycolipids
KW - growth factor
KW - lysosomal
KW - reactive oxygen species
N1 - Accession Number: 25232965; Moore, David F. 1 Gelderman, Monique P. 2 Ferreira, Paulo A. 3,4 Fuhrmann, Steven R. 5 Haiqing Yi 3 Elkahloun, Abdel 6 Lix, Lisa M. 7 Brady, Roscoe O. 8; Email Address: rb57v@nih.gov Schiffmann, Raphael 8; Email Address: rs4e@nih.gov Goldin, Ehud 8; Affiliation: 1: Section of Neurology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2 2: Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20857 3: Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710 4: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 5: IOMAI Corporation, Gaithersburg, MD 20878 6: National Institute of Neurological Disorders and Strokes, Micro-Array Core Facility, Bethesda, MD 20892 7: Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2 8: Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Strokes/National Institutes of Health, Bethesda, MD 20892; Source Info: 5/8/2007, Vol. 104 Issue 19, p8065; Subject Term: GENOMICS; Subject Term: METABOLIC disorders; Subject Term: GENETIC disorders; Subject Term: GLYCOSPHINGOLIPIDS; Subject Term: GENE expression; Subject Term: GROWTH factors; Subject Term: SUPEROXIDE dismutase; Author-Supplied Keyword: glycolipids; Author-Supplied Keyword: growth factor; Author-Supplied Keyword: lysosomal; Author-Supplied Keyword: reactive oxygen species; Number of Pages: 6p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1073/pnas.0701991104
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Belongia, E.
AU - Izurieta, H.
AU - Braun, M.M.
AU - Ball, R.
AU - Haber, P.
AU - Baggs, J.
AU - Weintraub, E.
AU - Gargiullo, P.
AU - Vellozzi, C.
AU - Iskander, J.
AU - Patel, M.
AU - Parashar, U.
AU - Cortese, M.
AU - Gentsch, J.
AU - Wallace, G.
AU - Bartlett, D.
T1 - Postmarketing Monitoring of Intussusception After RotaTeq™ Vaccination-- United States, February 1, 2006- February 15,2007.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/05/09/
VL - 297
IS - 18
M3 - Article
SP - 1972
EP - 1976
SN - 00987484
AB - This article presents information from the United States Centers for Disease Control and Prevention (CDC). The CDC looked into the postmarketing monitoring of the rotovirus vaccine RotaTeq in infants in the United States. Concern had been raised that there might be a chance of intussusception following the recall of a similar vaccine called Rotashield. The study found no cases of intussusception occurred within 30 days of vaccination with RotaTeq although 8 cases resulted from the administration of other vaccines.
KW - ROTAVIRUS diseases -- Vaccination
KW - VACCINES
KW - INTUSSUSCEPTION in children
KW - INTESTINAL intussusception
KW - INFANT health services
KW - SAFETY measures
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 24999305; Belongia, E. 1 Izurieta, H. 2 Braun, M.M. 2 Ball, R. 2 Haber, P. 3 Baggs, J. 3 Weintraub, E. 3 Gargiullo, P. 3 Vellozzi, C. 3 Iskander, J. 3 Patel, M. 4 Parashar, U. 4 Cortese, M. 4 Gentsch, J. 4 Wallace, G. 4 Bartlett, D. 4; Affiliation: 1: Marshfield Clinic, Marshfield, Wisconsin 2: Center for Biologics Evaluation and Research, Food and Drug Administration 3: Immunization Safety Office,Office of the Chief Science Officer 4: National Center for Immunization and Respiratory Diseases, CDC; Source Info: 5/9/2007, Vol. 297 Issue 18, p1972; Subject Term: ROTAVIRUS diseases -- Vaccination; Subject Term: VACCINES; Subject Term: INTUSSUSCEPTION in children; Subject Term: INTESTINAL intussusception; Subject Term: INFANT health services; Subject Term: SAFETY measures; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Pine, Michael
AU - Jordan, Harmon S.
AU - Elixhauser, Anne
AU - Fry, Donald E.
AU - Hoaglin, David C.
T1 - Hospital Mortality Risk Adjustment Using Claims Data.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/05/09/
VL - 297
IS - 18
M3 - Letter
SP - 1984
EP - 1984
SN - 00987484
AB - This article presents a reply to a letter to the editor in response to "Enhancement of claims data to improve risk adjustment of hospital mortality," by M. Pine, H.S. Jordan and colleagues.
KW - LETTERS to the editor
KW - HOSPITAL administration
N1 - Accession Number: 24999320; Pine, Michael 1; Email Address: mpine@aol.com Jordan, Harmon S. 2 Elixhauser, Anne 3 Fry, Donald E. 1 Hoaglin, David C. 2; Affiliation: 1: Michael Pine and Associates Inc. Chicago, Ill 2: Abt Associates, Inc Cambridge, Mass. 3: Agency for Healthcare Research and Quality Rockville, Md; Source Info: 5/9/2007, Vol. 297 Issue 18, p1984; Subject Term: LETTERS to the editor; Subject Term: HOSPITAL administration; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rabablert, Jundee
AU - Wasi, Chantapong
AU - Kinney, Richard
AU - Kasisith, Jitra
AU - Pitidhammabhorn, Dhanesh
AU - Ubol, Sukathida
T1 - Attenuating characteristics of DEN-2 PDK53 in flavivirus-naïve peripheral blood mononuclear cells
JO - Vaccine
JF - Vaccine
Y1 - 2007/05/10/
VL - 25
IS - 19
M3 - Article
SP - 3896
EP - 3905
SN - 0264410X
AB - Abstract: A live-attenuated DEN-2 virus, DEN-2 strain 16681-PDK53, has been found to be attenuated for both humans and mice with an unknown mechanism. To partially answer this question, responses of flavivirus-naïve primary human PBMC to infection with attenuated DEN-2 PDK53 (D2/IC-VV45R) virus and its parental, virulent DEN-2 16681 virus (D2/IC-30P-A) were investigated at the cellular and genetic levels using cDNA array analysis. Both DEN-2 viruses produced similar replication kinetics in flavivirus-naïve PBMC. In contrast, virulent DEN-2 virus caused a higher percentage of apoptotic death. A macro-array analysis showed that the virulent D2/IC-30P-A virus induced changes in the expression of a greater number of genes than did the attenuated D2/IC-VV45R virus, 31 genes versus 19 genes, respectively, by 24h post-infection. Interestingly, both viruses stimulated cytokines known to be virulence factors for DEN virus infection, such as IL-1β, IL-6, IL-8, IL-10, MIP-1β, and MIP-1α. The virulent virus additionally up-regulates immune suppression factors and down-regulates immune activator and growth factors. In conclusion, our data demonstrated that D2-PDK53 effected less change in PBMC than D2-16681 in terms of observable cellular effect and expression of cytokine and chemokine related genes. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Microorganisms
KW - Genes
KW - Cytokines
KW - cDNA array analysis
KW - Dengue virus
KW - Vaccine development
N1 - Accession Number: 24787145; Rabablert, Jundee 1,2; Wasi, Chantapong 2; Kinney, Richard 3; Kasisith, Jitra 4; Pitidhammabhorn, Dhanesh 4; Ubol, Sukathida 4; Email Address: scsul@mahidol.ac.th; Affiliations: 1: Center for Vaccine Development, Institute of Science and Technology, Mahidol University, Nakhon Pathom, Thailand; 2: Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 3: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, CO, United States; 4: Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Issue Info: May2007, Vol. 25 Issue 19, p3896; Thesaurus Term: Vaccination; Thesaurus Term: Microorganisms; Subject Term: Genes; Subject Term: Cytokines; Author-Supplied Keyword: cDNA array analysis; Author-Supplied Keyword: Dengue virus; Author-Supplied Keyword: Vaccine development; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.01.096
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yin, Xuejun J.
AU - Dong, Caroline C.
AU - Ma, Jane Y. C.
AU - Roberts, Jenny R.
AU - Antonini, James M.
AU - Ma, Joseph K. H.
T1 - Suppression of Phagocytic and Bactericidal Functions of Rat Alveolar Macrophages by the Organic Component of Diesel Exhaust Particles.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/05/15/
VL - 70
IS - 10
M3 - Article
SP - 820
EP - 828
SN - 15287394
AB - Exposure to diesel exhaust particles (DEP) was shown to increase the susceptibility of the lung to bacterial infection in rats. In this study, the effects of DEP on alveolar macrophage (AM) phagocytic and bactericidal functions and cytokine secretion by AM and lymphocytes in response to Listeria monocytogenes infection were investigated in vitro and the roles of different DEP components in these processes were compared. Exposure to DEP or the organic extracts of DEP (eDEP) significantly decreased the phagocytosis and killing of L. monocytogenes by AM obtained from normal rats. Washed DEP (wDEP) also decreased AM phagocytosis and bacterial killing to a lesser extent, whereas carbon black (CB) reduced AM phagocytosis but had no significant effect on AM bactericidal activity. DEP or eDEP concentration-dependently suppressed L. monocytogenes-induced secretion of tumor necrosis factor-α, interleukin (IL)-1β, and IL-12 by AM and of IL-2 and interferon-γ by lymphocytes obtained from L. monocytogenes-infected rats, but augmented the AM secretion of IL-10. wDEP or CB, however, exerted little or no effect on these L. monocytogenes-induced cytokines. These results provide direct evidence that DEP, through the actions of organic components, suppresses AM phagocytic and bactericidal functions in vitro. Inhibition of AM phagocytic function and alterations of AM and lymphocyte cytokine secretion by DEP and DEP organic compounds may be implicated in the diminished AM bactericidal activity and the lymphatic arm of the host immune system, thus resulting in an suppressed pulmonary clearance of L. monocytogenes and an increased susceptibility of the lung to bacterial infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - RATS as laboratory animals
KW - CYTOKINES
KW - GLYCOPROTEINS
KW - PHAGOCYTOSIS
KW - ANTIGEN-antibody reactions
KW - ENDOCYTOSIS
KW - IMMUNE response
KW - IMMUNOLOGY
N1 - Accession Number: 24826912; Yin, Xuejun J. 1; Email Address: xyin@hsc.wvu.edu Dong, Caroline C. 2 Ma, Jane Y. C. 3 Roberts, Jenny R. 3 Antonini, James M. 3 Ma, Joseph K. H. 2; Affiliation: 1: School of Medicine, West Virginia University, Morgantowns, West Virginia, USA 2: School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA 3: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: May2007, Vol. 70 Issue 10, p820; Subject Term: MACROPHAGES; Subject Term: RATS as laboratory animals; Subject Term: CYTOKINES; Subject Term: GLYCOPROTEINS; Subject Term: PHAGOCYTOSIS; Subject Term: ANTIGEN-antibody reactions; Subject Term: ENDOCYTOSIS; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1080/15287390701209766
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sung Gu Han
AU - Castranova, Vince
AU - Vallyathan, Val
T1 - Comparative Cytotoxicity of Cadmium and Mercury in a Human Bronchial Epithelial Cell Line (BEAS-2B) and its Role in Oxidative Stress and Induction of Heat Shock Protein 70.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/05/15/
VL - 70
IS - 10
M3 - Article
SP - 852
EP - 860
SN - 15287394
AB - A number of toxic heavy metals, such as cadmium (Cd) and mercury (Hg), are widely used in occupational settings, and exposure to these metals is associated with the development of pulmonary diseases. Cytotoxicity, apoptosis, and reactive oxygen species (ROS) generation were tested to compare the biological reactivity of these two heavy metals using a human bronchial epithelial cell line, BEAS-2B. Further, heat-shock protein 70 (Hsp70) expression was observed as a sensitive indicator of cellular stress. Exposure to metals (0-50 μM) for 72 h showed more significant cytotoxicity in Cd-treated than Hg-treated cells. Apoptosis was significantly increased in the cells exposed to 50 μM of Cd (3.5-fold) and Hg (3.6-fold). Cd and Hg produced an induction of Hsp70 protein as assayed by Western blotting and enzyme-linked immunosorbent assay (ELISA). Induction of Hsp70 protein by these metals was inhibited by addition of N-acetylcysteine. However, addition of catalase blocked the synthesis of Hsp70 only in Hg-treated cells. Hsp70B and Hsp70C mRNA expression was induced by both metals, while Hsp70A mRNA expression showed no change. Electron spin resonance (ESR) tests showed that hydroxyl radical generation was greater in the reaction of cells with Hg compared to Cd. Intracellular generation of ROS was detected in the cells exposed to both Cd and Hg. These results suggest that both cytotoxicity and apoptosis were significantly elevated with all metals tested; however, Cd was relatively more toxic. Hsp70 protein and mRNA were sensitive to exposure to these metals. Depletion of sulfhydryl groups of cellular proteins and generation of ROS may be involved in metal-induced lung cell damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM
KW - MERCURY
KW - OXIDATIVE stress
KW - HEAT shock proteins
KW - PROTEINS
KW - CELL-mediated cytotoxicity
KW - APOPTOSIS
KW - ENZYME-linked immunosorbent assay
KW - MESSENGER RNA
N1 - Accession Number: 24826909; Sung Gu Han 1 Castranova, Vince 2 Vallyathan, Val 2; Email Address: vav1@cdc.gov; Affiliation: 1: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA 2: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: May2007, Vol. 70 Issue 10, p852; Subject Term: CADMIUM; Subject Term: MERCURY; Subject Term: OXIDATIVE stress; Subject Term: HEAT shock proteins; Subject Term: PROTEINS; Subject Term: CELL-mediated cytotoxicity; Subject Term: APOPTOSIS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: MESSENGER RNA; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 10 Graphs; Document Type: Article
L3 - 10.1080/15287390701212695
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pei Zhang
AU - Wu, Charles G.
AU - Mihalik, Kathleen
AU - Virata-Theimer, Maria Luisa
AU - Yu, Mei-Ying W.
AU - Altert, Harvey J.
AU - Feinstone, Stephen M.
T1 - Hepatitis C virus epitope-specific neutralizing antibodies in Igs prepared from human plasma.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/05/15/
VL - 104
IS - 20
M3 - Article
SP - 8449
EP - 8454
SN - 00278424
AB - Neutralizing antibodies directed against hepatitis (virus (HCV) are present in Igs made from anti-HCV-positive plasma. However, these HCV-specific Igs are largely ineffective in vivo. The mechanism for the poor effectiveness is currently unknown. We hypothesize that the presence of nonneutralizing antibodies in HCV-specific Igs interferes with the function of neutralizing antibodies, resulting in the reduction or blockage of their effect. In the present study, we identified at least two epitopes at amino acid residues 412-419 (epitope I) and 434-446 (epitope II), located downstream of the hypervariable region I within the HCV E2 protein. We demonstrated that epitope I, but not epitope II, was implicated in HCV neutralization and that binding of a nonneutralizing antibody to epitope II completely disrupted virus neutralization mediated by antibody binding at epitope I. The dynamic interaction between nonneutralizing and neutralizing antibodies may thus play a key role in determining the outcomes of HCV infection. Further exploration of this interplay should lead to a better understanding of the mechanisms of neutralization and immune escape and may indicate pathways for the manufacture of an effective HCV-specific Ig product for immune prophylaxis of HCV infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENIC determinants
KW - HEPATITIS C virus
KW - IMMUNOGLOBULINS
KW - AMINO acids
KW - NEUTRALIZATION (Chemistry)
KW - anti-hepatitis C virus-positive plasma
KW - Ig intravenous
N1 - Accession Number: 25301029; Pei Zhang 1; Email Address: pei.zhang@fda.hhs.gov Wu, Charles G. 2 Mihalik, Kathleen 3 Virata-Theimer, Maria Luisa 1 Yu, Mei-Ying W. 1 Altert, Harvey J. 4; Email Address: halter@dtm.cc.nih.gov Feinstone, Stephen M. 3; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892 2: Division of Gastroenterology Products. Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 3: Division of ViraI Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892 4: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892; Source Info: 5/15/2007, Vol. 104 Issue 20, p8449; Subject Term: ANTIGENIC determinants; Subject Term: HEPATITIS C virus; Subject Term: IMMUNOGLOBULINS; Subject Term: AMINO acids; Subject Term: NEUTRALIZATION (Chemistry); Author-Supplied Keyword: anti-hepatitis C virus-positive plasma; Author-Supplied Keyword: Ig intravenous; Number of Pages: 6p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1073/pnas.0703039104
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25301029&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106128356
T1 - Issues in the registration of clinical trials.
AU - Zarin DA
AU - Ide NC
AU - Tse T
AU - Harlan WR
AU - West JC
AU - Lindberg DA
AU - Zarin, Deborah A
AU - Ide, Nicholas C
AU - Tse, Tony
AU - Harlan, William R
AU - West, Joyce C
AU - Lindberg, Donald A B
Y1 - 2007/05/16/
N1 - Accession Number: 106128356. Language: English. Entry Date: 20070803. Revision Date: 20161114. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Public Health. Grant Information: //Intramural NIH HHS/United States. NLM UID: 7501160.
KW - Clinical Trials -- Ethical Issues
KW - Clinical Trials -- Standards
KW - Registration -- Standards
KW - Communication
KW - Funding Source
KW - Information Retrieval
KW - Information Storage
KW - International Relations
KW - National Library of Medicine (U.S.)
KW - Resource Databases
KW - United States
KW - Human
SP - 2112
EP - 2120
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 297
IS - 19
CY - Chicago, Illinois
PB - American Medical Association
AB - Public concerns about the perils associated with incomplete or delayed reporting of results from clinical trials has heightened interest in trial registries and results databases. Here we review the current status of trial registration efforts and the challenges in developing a comprehensive system of trial registration and reporting of results. ClinicalTrials.gov, the largest trial registry with 36 249 trials from approximately 140 countries, has procedures in place to help ensure that records are valid and informative. Key challenges include the need to minimize inadvertent duplicate registrations, to ensure that interventions have unambiguous names, and to have a search engine that identifies all trials that meet a user's specifications. Recent policy initiatives have called for the development of a database of trial results. Several issues confound the implementation of such a database, including the lack of an accepted format or process for providing summaries of trial results to the public and concerns about disseminating data in the absence of independent scientific review.
SN - 0098-7484
AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md, USA
AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md, USA. dzarin@mail.nih.gov
U2 - PMID: 17507347.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Martella, Vito
AU - Elia, Gabriella
AU - Lucente, Maria Stella
AU - Decaro, Nicola
AU - Lorusso, Eleonora
AU - Banyai, Krisztian
AU - Blixenkrone-Møller, Merete
AU - Lan, Nguyen Thi
AU - Yamaguchi, Ryoji
AU - Cirone, Francesco
AU - Carmichael, Leland Eugene
AU - Buonavoglia, Canio
T1 - Genotyping canine distemper virus (CDV) by a hemi-nested multiplex PCR provides a rapid approach for investigation of CDV outbreaks
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2007/05/16/
VL - 122
IS - 1/2
M3 - Article
SP - 32
EP - 42
SN - 03781135
AB - Abstract: CDV is a highly contagious viral pathogen causing a lethal systemic disease in dogs and other carnivores. Several lineages or genotypes of CDV exist that are variously distributed throughout several continents. Legal or uncontrolled trading of animals may modify the epidemiology of CDV, introducing novel strains in CDV-naïve areas or accounting for the resurgence of CDV in areas where vaccine prophylaxis was effective and successful to control the disease. A hemi-nested PCR system was developed to genotype strains of the major CDV lineages, America-1, Europe, Asia-1, Asia-2 and Arctic. The assay was tested using a collection of 27 laboratory and vaccine strains and of 36 field CDV strains. Distinct lineages could be differentiated by specific primers targeted to the H gene. The method could be useful for molecular epidemiological studies of CDV, providing a tool for large-scale studies, and for the diagnosis of vaccine-related disease. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANINE distemper virus
KW - CARNIVORA
KW - COMMUNICABLE diseases -- Transmission
KW - GENETIC polymorphisms
KW - Canine distemper virus
KW - Characterization
KW - Protein H
KW - RT-PCR
N1 - Accession Number: 24785480; Martella, Vito 1; Email Address: v.martella@veterinaria.uniba.it Elia, Gabriella 1 Lucente, Maria Stella 1 Decaro, Nicola 1 Lorusso, Eleonora 1 Banyai, Krisztian 2 Blixenkrone-Møller, Merete 3 Lan, Nguyen Thi 4 Yamaguchi, Ryoji 4 Cirone, Francesco 1 Carmichael, Leland Eugene 5 Buonavoglia, Canio 1; Affiliation: 1: Department of Animal Health and Well-being, University of Bari, Valenzano, Bari, Italy 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary 3: Laboratory of Virology, Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Stigbojlen 7, 1870 Frederiksberg C, Copenhagen, Denmark 4: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan 5: James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA; Source Info: May2007, Vol. 122 Issue 1/2, p32; Subject Term: CANINE distemper virus; Subject Term: CARNIVORA; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: GENETIC polymorphisms; Author-Supplied Keyword: Canine distemper virus; Author-Supplied Keyword: Characterization; Author-Supplied Keyword: Protein H; Author-Supplied Keyword: RT-PCR; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vetmic.2007.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hsia, Chu Chieh
AU - Chizhikov, Vladimir E.
AU - Yang, Amy X.
AU - Selvapandiyan, Angamuthu
AU - Hewlett, Indira
AU - Duncan, Robert
AU - Puri, Raj K.
AU - Nakhasi, Hira L.
AU - Kaplan, Gerardo G.
T1 - Microarray multiplex assay for the simultaneous detection and discrimination of hepatitis B, hepatitis C, and human immunodeficiency type-1 viruses in human blood samples
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2007/05/18/
VL - 356
IS - 4
M3 - Article
SP - 1017
EP - 1023
SN - 0006291X
AB - Abstract: Hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus type-1 (HIV-1) are transfusion-transmitted human pathogens that have a major impact on blood safety and public health worldwide. We developed a microarray multiplex assay for the simultaneous detection and discrimination of these three viruses. The microarray consists of 16 oligonucleotide probes, immobilized on a silylated glass slide. Amplicons from multiplex PCR were labeled with Cy-5 and hybridized to the microarray. The assay detected 1 International Unit (IU), 10IU, 20IU of HBV, HCV, and HIV-1, respectively, in a single multiplex reaction. The assay also detected and discriminated the presence of two or three of these viruses in a single sample. Our data represent a proof-of-concept for the possible use of highly sensitive multiplex microarray assay to screen and confirm the presence of these viruses in blood donors and patients. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS viruses
KW - PATHOGENIC microorganisms
KW - BLOOD transfusion
KW - BLOOD donors
KW - Blood-borne virus
KW - Hepatitis B virus (HBV)
KW - Hepatitis C virus (HCV)
KW - Human immunodeficiency virus type-1 (HIV-1)
KW - Microarray technology
KW - Multiplex detection and discrimination
KW - PCR
N1 - Accession Number: 24609419; Hsia, Chu Chieh 1; Email Address: chuchieh.hsia@fda.hhs.gov Chizhikov, Vladimir E. 2 Yang, Amy X. 3 Selvapandiyan, Angamuthu 1 Hewlett, Indira 1 Duncan, Robert 1 Puri, Raj K. 3 Nakhasi, Hira L. 1 Kaplan, Gerardo G. 1; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA 2: Division of Viral Products, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA 3: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Review, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: May2007, Vol. 356 Issue 4, p1017; Subject Term: HEPATITIS viruses; Subject Term: PATHOGENIC microorganisms; Subject Term: BLOOD transfusion; Subject Term: BLOOD donors; Author-Supplied Keyword: Blood-borne virus; Author-Supplied Keyword: Hepatitis B virus (HBV); Author-Supplied Keyword: Hepatitis C virus (HCV); Author-Supplied Keyword: Human immunodeficiency virus type-1 (HIV-1); Author-Supplied Keyword: Microarray technology; Author-Supplied Keyword: Multiplex detection and discrimination; Author-Supplied Keyword: PCR; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2007.03.087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24609419&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Tomkinson, Alun
AU - Fox, Rosemary
AU - Temple, Mark
T1 - More advice to clinicians.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2007/05/19/
VL - 334
IS - 7602
M3 - Letter
SP - 1019
EP - 1019
SN - 09598146
AB - This article presents a letter to the editor in response to "Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial," by O.P. Alho and colleagues in the May 5, 2007 issue.
KW - LETTERS to the editor
KW - TONSILLECTOMY
N1 - Accession Number: 25255031; Tomkinson, Alun 1; Email Address: alun.tomkinson@cardiffandvale.wales.nhs.uk Fox, Rosemary 2 Temple, Mark 2; Affiliation: 1: University Hospital of Wales, Cardiff CF14 4XW 2: National Public Health Service for Wales, Cardiff CF20 3NW; Source Info: 5/19/2007, Vol. 334 Issue 7602, p1019; Subject Term: LETTERS to the editor; Subject Term: TONSILLECTOMY; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Kyu-Bong
AU - Anand, Sathanandam S.
AU - Muralidhara, Srinivasa
AU - Kim, Hyo J.
AU - Bruckner, James V.
T1 - Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats
JO - Toxicology
JF - Toxicology
Y1 - 2007/05/20/
VL - 234
IS - 3
M3 - Article
SP - 194
EP - 202
SN - 0300483X
AB - Abstract: The acute neurotoxicity of pyrethroid insecticides varies markedly with the dosage vehicle employed. The objective of the present study was to assess the influence of two common vehicles on the bioavailability and toxicokinetics (TK) of a representative pyrethroid insecticide, deltamethrin (DLM), to determine whether the vehicles influence toxic potency by modifying the chemical''s TK. Adult, male Sprague–Dawley rats were administered DLM iv or po, either by dissolving it in glycerol formal (GF) or by suspending it in Alkamuls® (AL). Groups of rats received 10mg DLM/kg by gavage in each vehicle, as well as 2mg/kg in GF or 10mg/kg in AL by iv injection. Serial blood samples were collected over 96h and analyzed for their DLM content by HPLC. In a second experiment, plasma, brain, fat, liver and lung DLM concentrations were measured 2h after giving 10mg DLM/kg orally in GF or AL. In a third experiment rats received 2 or 10mg DLM/kg iv in AL or 2mg DLM/kg iv in GF. Lung DLM content was determined 15min post injection. DLM particle size in both formulations was measured under a phase contrast microscope. DLM appeared to be completely dissolved in GF, while particle size ranged from <5 to >50μm in AL. The bioavailability of DLM in the aqueous AL suspension was ∼9-fold lower than in GF (1.7% versus 15%). Blood C max (0.95±0.27 versus 0.09±0.01μg/ml) and AUC048h (5.49±0.22 versus 0.61±0.14μg·h/ml) were markedly higher in the GF gavage group. Tissue DLM levels were also significantly higher in the GF animals at 2h. The 10mg/kg po and 2mg/kg iv doses of DLM in GF produced moderate salivation and slight tremors. Rats receiving the insecticide in AL were asymptomatic. IV injection of the AL suspension resulted in trapping of much of the dose in the pulmonary capillaries. As anticipated, the injected suspension had a longer half-life and slower clearance than did the GF formulation. In summary, limited dissolution of the highly lipophilic DLM particles in the AL suspension severely limited DLM''s GI absorption, bioavailability, target organ deposition and acute neurotoxic potency. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MURIDAE
KW - NEUROTOXICOLOGY
KW - PESTICIDES industry
KW - BILIARY tract
KW - Acute neurotoxicity
KW - Deltamethrin
KW - Internal exposure
KW - Pyrethroid
KW - Vehicle effect
N1 - Accession Number: 24867149; Kim, Kyu-Bong 1,2 Anand, Sathanandam S. 1 Muralidhara, Srinivasa 1 Kim, Hyo J. 1 Bruckner, James V. 1; Email Address: bruckner@rx.uga.edu; Affiliation: 1: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30605, USA 2: Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea; Source Info: May2007, Vol. 234 Issue 3, p194; Subject Term: MURIDAE; Subject Term: NEUROTOXICOLOGY; Subject Term: PESTICIDES industry; Subject Term: BILIARY tract; Author-Supplied Keyword: Acute neurotoxicity; Author-Supplied Keyword: Deltamethrin; Author-Supplied Keyword: Internal exposure; Author-Supplied Keyword: Pyrethroid; Author-Supplied Keyword: Vehicle effect; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2007.02.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - King, Randy L.
AU - Herman, Bruce A.
AU - Maruvada, Subha
AU - Wear, Keith A.
AU - Harris, Gerald R.
T1 - Development of a HIFU Phantom.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2007/05/21/
VL - 911
IS - 1
M3 - Article
SP - 351
EP - 356
PB - American Institute of Physics
SN - 0094243X
AB - The field of high intensity focused ultrasound (HIFU) is developing rapidly. For basic research, quality control, and regulatory assessment a reusable phantom that has both thermal and acoustic properties close to that of soft tissue is critical. A hydrogel-based tissue mimicking material (TMM) has been developed that shows promise for such a phantom. The acoustic attenuation, speed of sound, B/A, thermal diffusivity and conductivity, as well as the cavitation threshold, were measured and found to mimic published values for soft tissue. The attenuation of 0.53f1.04 from 1 MHz to 8 MHz, as well as the sound speed of 1565 m/s and the tissue-like image quality, indicate the usefulness of the TMM for ultrasound imaging applications. These properties along with the thermal conductivity of 0.58 W/m- °C, diffusivity of 0.15 (mm2)/s, and the ability to withstand temperatures above 95 °C make this material appropriate for HIFU applications. The TMM also allows for the embedding of thermocouples and the formation of wall-less vessels that do not deteriorate as a result of continuous flow of blood mimicking fluids through the material. Tissue characteristics are strongly dependent on the fabrication technique, and care must be taken to achieve reproducible results. Note: This research was supported by the Defense Advanced Research Projects Agency (DARPA). © 2007 American Institute of Physics [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APPARITIONS
KW - QUALITY control
KW - THERMAL diffusivity
KW - ATTENUATION (Physics)
KW - THERMOCOUPLES
KW - UNITED States
KW - High intensity focused ultrasound
KW - Phantoms
KW - UNITED States. Defense Advanced Research Projects Agency
KW - AMERICAN Institute of Physics
N1 - Accession Number: 25289076; King, Randy L. 1 Herman, Bruce A. 1 Maruvada, Subha 1 Wear, Keith A. 1 Harris, Gerald R. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, 9200 Corporate Blvd., Mail Stop HFZ-170, Rockville, MD 20850, USA; Source Info: 2007, Vol. 911 Issue 1, p351; Subject Term: APPARITIONS; Subject Term: QUALITY control; Subject Term: THERMAL diffusivity; Subject Term: ATTENUATION (Physics); Subject Term: THERMOCOUPLES; Subject Term: UNITED States; Author-Supplied Keyword: High intensity focused ultrasound; Author-Supplied Keyword: Phantoms; Company/Entity: UNITED States. Defense Advanced Research Projects Agency Company/Entity: AMERICAN Institute of Physics; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; Number of Pages: 6p; Illustrations: 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1063/1.2744296
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Bo
AU - Santhanam, Suresh
AU - Schultz, Lawrence
AU - Jeffries-EL, Malika
AU - Iovu, Mihaela C.
AU - Sauvé, Genevieve
AU - Cooper, Jessica
AU - Zhang, Rui
AU - Revelli, Joseph C.
AU - Kusne, Aaron G.
AU - Snyder, Jay L.
AU - Kowalewski, Tomasz
AU - Weiss, Lee E.
AU - McCullough, Richard D.
AU - Fedder, Gary K.
AU - Lambeth, David N.
T1 - Inkjet printed chemical sensor array based on polythiophene conductive polymers
JO - Sensors & Actuators B: Chemical
JF - Sensors & Actuators B: Chemical
Y1 - 2007/05/21/
VL - 123
IS - 2
M3 - Article
SP - 651
EP - 660
SN - 09254005
AB - Abstract: Multiple regioregular polythiophene polymers with a variety of side chains, end groups and secondary polymer chains were used as active sensing layers in a single chip chemresistor sensor array device. A custom inkjet system was used to selectively deposit the polymers onto the array of transduction electrodes. The sensor demonstrated sensitivity and selectivity for detection and discrimination of volatile organic compounds (VOCs). The conductivity responses to VOC vapors are dependent on the chemical structure of the polymers. For certain VOCs, conductivity increased in some polymers, while it decreased in others. Principal component analysis (PCA) of sensor responses was used to discriminate between the tested VOCs. These results are correlated to the chemical structures of the different polymers, and qualitative hypothesis of chemical sensing mechanisms are proposed. This research demonstrates the potential for using such devices in VOC detection and discrimination sensing applications. [Copyright &y& Elsevier]
AB - Copyright of Sensors & Actuators B: Chemical is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYTHIOPHENES
KW - POLYMERS
KW - CHEMICAL detectors
KW - VOLATILE organic compounds
KW - Chemresistor
KW - Gas sensing
KW - Inkjet printing
KW - Polythiophene
KW - Volatile organic compounds
N1 - Accession Number: 24969773; Li, Bo 1 Santhanam, Suresh 1 Schultz, Lawrence 2 Jeffries-EL, Malika 3 Iovu, Mihaela C. 3 Sauvé, Genevieve 3 Cooper, Jessica 3 Zhang, Rui 3 Revelli, Joseph C. 4 Kusne, Aaron G. 1 Snyder, Jay L. 4 Kowalewski, Tomasz 3 Weiss, Lee E. 2 McCullough, Richard D. 3 Fedder, Gary K. 1 Lambeth, David N. 1; Email Address: lambeth@ece.cmu.edu; Affiliation: 1: Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA 2: Robotics Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA 3: Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA 4: National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA; Source Info: May2007, Vol. 123 Issue 2, p651; Subject Term: POLYTHIOPHENES; Subject Term: POLYMERS; Subject Term: CHEMICAL detectors; Subject Term: VOLATILE organic compounds; Author-Supplied Keyword: Chemresistor; Author-Supplied Keyword: Gas sensing; Author-Supplied Keyword: Inkjet printing; Author-Supplied Keyword: Polythiophene; Author-Supplied Keyword: Volatile organic compounds; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.snb.2006.09.064
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24969773&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Qi Chen
AU - Espey, Michael Graham
AU - Sun, Andrew Y.
AU - Lee, Je-Hyuk
AU - Krishna, Murali C.
AU - Shacter, Emily
AU - Choyke, Peter L.
AU - Pooput, Chaya
AU - Kirk, Kenneth L.
AU - Buettner, Garry R.
AU - Levine, Mark
T1 - Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/05/22/
VL - 104
IS - 21
M3 - Article
SP - 8749
EP - 8754
SN - 00278424
AB - Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in humans by i.v. administration, selectively kills some cancer cells but not normal cells. We proposed that pharmacologic ascorbate is a prodrug for preferential steady-state formation of ascorbate radical (Asc*-) and H2O2 in the extracellular space compared with blood. Here we test this hypothesis in vivo. Rats were administered parenteral (i.v. or i.p.) or oral ascorbate in typical human pharmacologic doses (≈0.25-0.5 mg per gram of body weight). After i.v. injection, ascorbate baseline concentrations of 50-100 μM in blood and extracellular fluid increased to peaks of >8 mM. After i.p. injection, peaks approached 3 mM in both fluids. By gavage, the same doses produced ascorbate concentrations of <150 μM in both fluids. In blood, Asc*- concentrations measured by EPR were undetectable with oral administration and always <50 nM with parenteral administration, even when corresponding ascorbate concentrations were >8 mM. After parenteral dosing, Asc*- concentrations in extracellular fluid were 4- to 12-fold higher than those in blood, were as high as 250 nM, and were a function of ascorbate concentrations. By using the synthesized probe peroxyxanthone, H2O2 in extracellular fluid was detected only after parenteral administration of ascorbate and when Asc*- concentrations in extracellular fluid exceeded 100 nM. The data show that pharmacologic ascorbate is a prodrug for preferential steady-state formation of Asc*- and H2O2 in the extracellular space but not blood. These data provide a foundation for pursuing pharmacologic ascorbate as a prooxidant therapeutic agent in cancer and infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOLOGY
KW - CELLS
KW - VITAMIN C
KW - EXTRACELLULAR fluid
KW - BODY fluids
KW - ascorbic acid
KW - cancer
KW - pharmacokinetics
KW - vitamin C
N1 - Accession Number: 25365595; Qi Chen 1 Espey, Michael Graham 2 Sun, Andrew Y. 1 Lee, Je-Hyuk 1 Krishna, Murali C. 2 Shacter, Emily 3 Choyke, Peter L. 4 Pooput, Chaya 5 Kirk, Kenneth L. 5 Buettner, Garry R. 6 Levine, Mark 1; Email Address: markL@mail.nih.gov; Affiliation: 1: Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892. 2: Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892. 3: Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. 4: Molecular Imaging Program, National Cancer Institute, Bethesda, MD 20892. 5: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892. 6: Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242.; Source Info: 5/22/2007, Vol. 104 Issue 21, p8749; Subject Term: PHARMACOLOGY; Subject Term: CELLS; Subject Term: VITAMIN C; Subject Term: EXTRACELLULAR fluid; Subject Term: BODY fluids; Author-Supplied Keyword: ascorbic acid; Author-Supplied Keyword: cancer; Author-Supplied Keyword: pharmacokinetics; Author-Supplied Keyword: vitamin C; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1073/pnas.0702854104
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dobardzic, Azra
AU - Izurieta, Hector
AU - Woo, Emily Jane
AU - Iskander, John
AU - Shadomy, Sean
AU - Rupprecht, Charles
AU - Ball, Robert
AU - Miles Braun, M.
T1 - Safety review of the purified chick embryo cell rabies vaccine: Data from the Vaccine Adverse Event Reporting System (VAERS), 1997–2005
JO - Vaccine
JF - Vaccine
Y1 - 2007/05/22/
VL - 25
IS - 21
M3 - Article
SP - 4244
EP - 4251
SN - 0264410X
AB - Abstract: On October 20, 1997, the U.S. Food and Drug Administration (FDA) licensed Purified Chick Embryo Cell (PCEC, RabAvert®) vaccine against rabies in humans following clinical trials demonstrating safety and efficacy. From October 1997 through December 2005, the Vaccine Adverse Event Reporting System (VAERS) received 336 reports of adverse events (AEs) following vaccination with PCEC vaccine in the U.S.; there were no death reports. Serious events, including 20 hospitalizations and 13 neurological events, were described in 24 (7%) reports. There was no pattern among the 13 neurological AEs suggesting a plausible relationship to vaccination. A total of 20 AEs, 3 serious, were classified as possible anaphylaxis. There were 312 non-serious AEs (93%). Nineteen reports (6%) described that the vaccination series was discontinued because of non-serious AEs. Most reported AEs are non-serious and consistent with pre-licensure safety data. The rabies risk must be carefully considered before vaccine discontinuation. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Chicken embryos
KW - Rabies
KW - United States
KW - Adverse events
KW - PCEC vaccine
KW - RabAvert
KW - Rabies
KW - United States. Food & Drug Administration
N1 - Accession Number: 24867037; Dobardzic, Azra 1; Email Address: azra.dobardzic@fda.hhs.gov; Izurieta, Hector 1; Woo, Emily Jane 1; Iskander, John 2; Shadomy, Sean 2; Rupprecht, Charles 2; Ball, Robert 1; Miles Braun, M. 1; Affiliations: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA; 2: Centers for Disease Control and Prevention, Atlanta, GA, USA; Issue Info: May2007, Vol. 25 Issue 21, p4244; Thesaurus Term: VACCINATION; Subject Term: Chicken embryos; Subject Term: Rabies; Subject: United States; Author-Supplied Keyword: Adverse events; Author-Supplied Keyword: PCEC vaccine; Author-Supplied Keyword: RabAvert; Author-Supplied Keyword: Rabies ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.02.075
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pegula, S.
AU - Marsh, S. M.
AU - Jackson, L. L.
T1 - Fatal Occupational Injuries--United States, 2005.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/05/23/
VL - 297
IS - 20
M3 - Article
SP - 2193
EP - 2194
SN - 00987484
AB - This article presents news from the U.S. Centers for Disease Control and Prevention (CDC). Data from the annual census of fatal occupational injuries in the U.S. shows that in 2005 there were 4 deaths for every 100,000 workers. This is a decline in work related deaths of 8 percent since 1992. The highest percentages of deaths were due to highway accidents, followed by falls, being struck by objects and homicides. Men had a fatality rate about 12 times that of women and the information shows that injuries increase with age.
KW - TRAFFIC accidents
KW - FALLS (Accidents)
KW - WORK-related injuries
KW - TRAFFIC fatalities
KW - EMPLOYEES
KW - DEATH
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 25147569; Pegula, S. 1 Marsh, S. M. 2 Jackson, L. L. 2; Affiliation: 1: Bur of Labor Statistics, US Dept of Labor 2: Div of Safety Research, National Institute for Occupational Safety and Health, CDC.; Source Info: 5/23/2007, Vol. 297 Issue 20, p2193; Subject Term: TRAFFIC accidents; Subject Term: FALLS (Accidents); Subject Term: WORK-related injuries; Subject Term: TRAFFIC fatalities; Subject Term: EMPLOYEES; Subject Term: DEATH; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, D. H.
AU - Kang, J. U.
AU - Ilev, I. K.
T1 - Advanced confocal microscope using single hollow-core photonic bandgap fibre design.
JO - Electronics Letters
JF - Electronics Letters
Y1 - 2007/05/24/
VL - 43
IS - 11
M3 - Article
SP - 608
EP - 609
PB - Institution of Engineering & Technology
SN - 00135194
AB - A simple confocal microscope design based on a single hollow-core fibre approach has been developed and experimentally analysed. Key optical components are the use of a hollow-core photonic bandgap fibre and a holed-mirror beam-splitter, both of which provide significant reduction of Fresnel back-reflections at the fibre tips and total background level resulting in increased resolving confocal laser power. [ABSTRACT FROM AUTHOR]
AB - Copyright of Electronics Letters is the property of Institution of Engineering & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTONICS
KW - CONFOCAL microscopy
KW - MICROSCOPY
KW - LASERS
KW - OPTICS
N1 - Accession Number: 25149548; Kim, D. H. 1; Email Address: do-hyun.kim@fda.hhs.gov Kang, J. U. 2 Ilev, I. K. 1; Affiliation: 1: Center for Devices and Radiological Health, US Food and Drug Administration, Building 62, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA 2: Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA; Source Info: 5/24/2007, Vol. 43 Issue 11, p608; Subject Term: PHOTONICS; Subject Term: CONFOCAL microscopy; Subject Term: MICROSCOPY; Subject Term: LASERS; Subject Term: OPTICS; Number of Pages: 2p; Illustrations: 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1049/el:20070951
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jackson, Scott A.
AU - Mammel, Mark K.
AU - Patel, Isha R.
AU - Mays, Tammy
AU - Albert, Thomas J.
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Interrogating genomic diversity of E. coli O157:H7 using DNA tiling arrays
JO - Forensic Science International
JF - Forensic Science International
Y1 - 2007/05/24/
VL - 168
IS - 2/3
M3 - Article
SP - 183
EP - 199
SN - 03790738
AB - Abstract: Here, we describe a novel microarray-based approach for investigating the genomic diversity of Escherichia coli O157:H7 in a semi-high throughput manner using a high density, oligonucleotide-based microarray. This microarray, designed to detect polymorphisms at each of 60,000base-pair (bp) positions within an E. coli genome, is composed of overlapping 29-mer oligonucleotides specific for 60 equally spaced, 1000-bp loci of the E. coli O157:H7 strain EDL933 chromosome. By use of a novel 12-well microarray that permitted the simultaneous investigation of 12 strains, the genomes of 44 individual isolates of E. coli O157:H7 were interrogated. These analyses revealed more than 150 single nucleotide polymorphisms (SNPs) and several deletions and amplifications in the test strains. Pyrosequencing was used to confirm the usefulness of the novel SNPs by determining their allelic frequency among a collection of diverse isolates of E. coli O157:H7. The tiling DNA microarray system would be useful for the tracking and identification of individual strains of E. coli O157:H7 needed for forensic investigations. [Copyright &y& Elsevier]
AB - Copyright of Forensic Science International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENOMICS
KW - ESCHERICHIA coli
KW - NUCLEOTIDES
KW - DNA microarrays
KW - copy number polymorphism ( CNP )
KW - Escherichia coli O157:H7
KW - multi-nucleotide polymorphism ( MNP )
KW - Single nucleotide polymorphism
KW - single-nucleotide polymorphism ( SNP )
KW - Tiling DNA microarray
N1 - Accession Number: 24864627; Jackson, Scott A. 1 Mammel, Mark K. 1 Patel, Isha R. 1 Mays, Tammy 1 Albert, Thomas J. 2 LeClerc, J. Eugene 1 Cebula, Thomas A. 1; Email Address: Thomas.Cebula@fda.hhs.gov; Affiliation: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA 2: NimbleGen Systems Inc., Madison, WI 53711, USA; Source Info: May2007, Vol. 168 Issue 2/3, p183; Subject Term: GENOMICS; Subject Term: ESCHERICHIA coli; Subject Term: NUCLEOTIDES; Subject Term: DNA microarrays; Author-Supplied Keyword: copy number polymorphism ( CNP ); Author-Supplied Keyword: Escherichia coli O157:H7; Author-Supplied Keyword: multi-nucleotide polymorphism ( MNP ); Author-Supplied Keyword: Single nucleotide polymorphism; Author-Supplied Keyword: single-nucleotide polymorphism ( SNP ); Author-Supplied Keyword: Tiling DNA microarray; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.forsciint.2006.06.079
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24864627&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nguyen, Hong Nga
AU - Lee, Moon Soon
AU - Hwang, Dae Youn
AU - Kim, Young Kyu
AU - Yoon, Do Young
AU - Lee, Jae Woong
AU - Yun, Yeo Pyo
AU - Lee, Myung Koo
AU - Oh, Ki Wan
AU - Hong, Jin Tae
T1 - Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2007/05/25/
VL - 357
IS - 1
M3 - Article
SP - 174
EP - 180
SN - 0006291X
AB - Abstract: The learning and memory impairment of presenilin 2 transgenic mice was mentioned previously. In this study, exposing the presenilin 2 transfected PC12 cells to the 50 μM Aβ25–35, 30mM l-glutamate and 50μM H2O2 resulted in significant increase 8-oxodG and p53 levels of the cells expressing the mutant gene. The increase was also found in the mutant presenilin 2 transgenic mice brains age-dependently in comparison to that in the wild-type presenilin 2-transgenic mice and non-transgenic ones. These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer’s disease, and the influence of mutant presenilin 2 in Alzheimer’s disease may be brain regional and age related effects. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICE
KW - TRANSGENIC mice
KW - TRANSGENIC animals
KW - TRAMP mice
KW - 8-hydroxy-2′-deoxyguanosine base ( 8-oxodG )
KW - 8-oxodG
KW - Alzheimer’s disease
KW - Alzheimer’s disease ( AD )
KW - beta amyloid fragment 25–35 ( Aβ25–35 )
KW - empty vector ( Neo )
KW - mutant type ( mt )
KW - Neuronal cell
KW - p53
KW - Presenilin 2
KW - presenilin 2 ( PS2 )
KW - transgenic mice ( Tg )
KW - wild type ( wt )
N1 - Accession Number: 24782240; Nguyen, Hong Nga 1 Lee, Moon Soon 2 Hwang, Dae Youn 3 Kim, Young Kyu 3 Yoon, Do Young 4 Lee, Jae Woong 1 Yun, Yeo Pyo 1 Lee, Myung Koo 1 Oh, Ki Wan 1 Hong, Jin Tae 1; Email Address: jinthong@chungbuk.ac.kr; Affiliation: 1: College of Pharmacy, CBITRC, Chungbuk National University, 12, Gaeshin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea 2: National Institute of Environmental Research, Kyungseo-dong, Seo-gu, Incheon 404-780, Republic of Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, 5, Nokbun-dong, Eunpyung-gu, Seoul 122-704, Republic of Korea 4: Laboratory of Cell and Immunobiochemistry, Division of Bioscience and Biotechnology, Konkuk University, 1, Hwayang-dong, Gwangjin-gu, Seoul, Republic of Korea; Source Info: May2007, Vol. 357 Issue 1, p174; Subject Term: MICE; Subject Term: TRANSGENIC mice; Subject Term: TRANSGENIC animals; Subject Term: TRAMP mice; Author-Supplied Keyword: 8-hydroxy-2′-deoxyguanosine base ( 8-oxodG ); Author-Supplied Keyword: 8-oxodG; Author-Supplied Keyword: Alzheimer’s disease; Author-Supplied Keyword: Alzheimer’s disease ( AD ); Author-Supplied Keyword: beta amyloid fragment 25–35 ( Aβ25–35 ); Author-Supplied Keyword: empty vector ( Neo ); Author-Supplied Keyword: mutant type ( mt ); Author-Supplied Keyword: Neuronal cell; Author-Supplied Keyword: p53; Author-Supplied Keyword: Presenilin 2; Author-Supplied Keyword: presenilin 2 ( PS2 ); Author-Supplied Keyword: transgenic mice ( Tg ); Author-Supplied Keyword: wild type ( wt ); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2007.03.119
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wallace Adams
AU - John Spencer
AU - Lucinda Buhse
AU - Matthew Nelson
AU - Patrick Treado
T1 - Raman Chemical Imaging for Ingredient-specific Particle Size Characterization of Aqueous Suspension Nasal Spray Formulations: A Progress Report.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2007/05/28/
VL - 24
IS - 5
M3 - Article
SP - 934
EP - 945
SN - 07248741
AB - Abstract Purpose  This study was conducted to evaluate the feasibility of using Raman chemical imaging (i.e., Raman imaging microspectroscopy) to establish chemical identity, particle size and particle size distribution (PSD) for a representative corticosteroid in aqueous nasal spray suspension formulations. Materials and Methods  The Raman imaging PSD protocol was validated using polystyrene (PS) microsphere size standards (NIST-traceable). A Raman spectral library was developed for the active and inactive compounds in the formulation. Four nasal sprays formulated with beclomethasone dipropionate (BDP) ranging in size from 1.4 to 8.3 μm were imaged by both Raman and brightfield techniques. The Raman images were then processed to calculate the PSD for each formulation. Results  Within each region examined, active pharmaceutical ingredient (API) particles are unambiguously identified and the total number of those particles, particle size and PSD of API free of excipients and PSD of API particles adhered to other excipients are reported. Conclusions  Good statistical agreement is obtained between the reported and measured sizes of the PS microspheres. BDP particles were clearly distinguishable from those of excipients. Raman chemical imaging (RCI) is able to differentiate between and identify the chemical makeup of multiple components in complex BDP sample and placebo mixtures. The Raman chemical imaging method (coupled Raman and optical imaging) shows promise as a method for characterizing particle size and shape of corticosteroid in aqueous nasal spray suspension formulations. However, rigorous validation of RCI for PSD analysis is incomplete and requires additional research effort. Some specific areas of concern are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - PESTICIDES
KW - STABILIZING agents
KW - ANTI-inflammatory agents
N1 - Accession Number: 24890126; Wallace Adams 1 John Spencer 2 Lucinda Buhse 2 Matthew Nelson 3 Patrick Treado 3; Affiliation: 1: Food and Drug Administration/CDER/OPS Office of Generic Drugs Rockville Maryland USA Rockville Maryland USA 2: Food and Drug Administration/CDER/OPS Division of Pharmaceutical Analysis St. Louis Missouri USA St. Louis Missouri USA 3: ChemImage Corporation 7301 Penn Avenue Pittsburgh Pennsylvania 15208 USA 7301 Penn Avenue Pittsburgh Pennsylvania 15208 USA; Source Info: May2007, Vol. 24 Issue 5, p934; Subject Term: DRUGS; Subject Term: PESTICIDES; Subject Term: STABILIZING agents; Subject Term: ANTI-inflammatory agents; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chandra Chaurasia
AU - Markus Müller
AU - Edward Bashaw
AU - Eva Benfeldt
AU - Jan Bolinder
AU - Ross Bullock
AU - Peter Bungay
AU - Elizabeth DeLange
AU - Hartmut Derendorf
AU - William Elmquist
AU - Margareta Hammarlund-Udenaes
AU - Christian Joukhadar
AU - Dean Kellogg
AU - Craig Lunte
AU - Carl Nordstrom
AU - Hans Rollema
AU - Ronald Sawchuk
AU - Belinda Cheung
AU - Vinod Shah
AU - Lars Stahle
T1 - AAPS-FDA Workshop White Paper: Microdialysis Principles, Application and Regulatory Perspectives.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2007/05/28/
VL - 24
IS - 5
M3 - Article
SP - 1014
EP - 1025
SN - 07248741
AB - Abstract Many decisions in drug development and medical practice are based on measuring blood concentrations of endogenous and exogenous molecules. Yet most biochemical and pharmacological events take place in the tissues. Also, most drugs with few notable exceptions exert their effects not within the bloodstream, but in defined target tissues into which drugs have to distribute from the central compartment. Assessing tissue drug chemistry has, thus, for long been viewed as a more rational way to provide clinically meaningful data rather than gaining information from blood samples. More specifically, it is often the extracellular (interstitial) tissue space that is most closely related to the site of action (biophase) of the drug. Currently microdialysis (μD) is the only tool available that explicitly provides data on the extracellular space. Although μD as a preclinical and clinical tool has been available for two decades, there is still uncertainty about the use of μD in drug research and development, both from a methodological and a regulatory point of view. In an attempt to reduce this uncertainty and to provide an overview of the principles and applications of μD in preclinical and clinical settings, an AAPS-FDA workshop took place in November 2005 in Nashville, TN, USA. Stakeholders from academia, industry and regulatory agencies presented their views on μD as a tool in drug research and development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRESERVATION of organs, tissues, etc.
KW - PHARMACEUTICAL chemistry
KW - DRUG development
KW - BLOOD
N1 - Accession Number: 24890109; Chandra Chaurasia 1 Markus Müller 2 Edward Bashaw 3 Eva Benfeldt 4 Jan Bolinder 5 Ross Bullock 6 Peter Bungay 7 Elizabeth DeLange 8 Hartmut Derendorf 9 William Elmquist 10 Margareta Hammarlund-Udenaes 11 Christian Joukhadar 2 Dean Kellogg 12 Craig Lunte 13 Carl Nordstrom 14 Hans Rollema 15 Ronald Sawchuk 10 Belinda Cheung 10 Vinod Shah 16 Lars Stahle 17; Affiliation: 1: Office of Generic Drugs, Food and Drug Administration Division of Bioequivalence Rockville MD USA Rockville MD USA 2: Medical University Vienna Department of Clinical Pharmacology Vienna Austria Vienna Austria 3: US-FDA Division of Clinical Pharmacology III, Office of Clinical Pharmacology Silver Spring MD USA Silver Spring MD USA 4: University of Copenhagen Department of Dermatology Copenhagen Denmark Copenhagen Denmark 5: Karolinska University Hospital Huddinge, Karolinska Institutet Deptartment of Medicine Stockholm Sweden Stockholm Sweden 6: Medical College of Virginia Richmond VA USA Richmond VA USA 7: Office of Research Services, NIH Division of Bioengineering and Physical Science Bethesda MD USA Bethesda MD USA 8: LACDR Leiden The Netherlands Leiden The Netherlands 9: University of Florida Department of Pharmaceutics Gainesville FL USA Gainesville FL USA 10: University of Minnesota Department of Pharmaceutics Minneapolis MN USA Minneapolis MN USA 11: Uppsala University Department of Pharmaceutical Biosciences Uppsala Sweden Uppsala Sweden 12: The University of Texas Health Science Center at San Antonio Department of Medicine San Antonio TX USA San Antonio TX USA 13: University of Kansas Department of Chemistry Lawrence KS USA Lawrence KS USA 14: University Hospital Department of Neurosurgery Lund Sweden Lund Sweden 15: Pfizer Global Research Department Neuroscience Groton CT USA Groton CT USA 16: Pharmaceutical Federation North Potomac MD USA North Potomac MD USA 17: Astra Zeneca Södertälje Sweden Södertälje Sweden; Source Info: May2007, Vol. 24 Issue 5, p1014; Subject Term: PRESERVATION of organs, tissues, etc.; Subject Term: PHARMACEUTICAL chemistry; Subject Term: DRUG development; Subject Term: BLOOD; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106142808
T1 - National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007.
AU - Edwards JR
AU - Peterson KD
AU - Andrus ML
AU - Tolson JS
AU - Goulding JS
AU - Dudeck MA
AU - Mincey RB
AU - Pollock DA
AU - Horan TC
Y1 - 2007/06//
N1 - Accession Number: 106142808. Corporate Author: NHSN Facilities. Language: English. Entry Date: 20070831. Revision Date: 20150819. Publication Type: Journal Article; equations & formulas; statistics. Commentary: Stone PW. Introduction. (AM J INFECT CONTROL) Jun2007; 35 (5): 289-289. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Catheter-Related Infections -- Epidemiology -- United States
KW - Hospitals -- United States
KW - Pneumonia, Ventilator-Associated -- Epidemiology -- United States
KW - Birth Weight
KW - Catheters, Urinary -- Adverse Effects
KW - Catheters, Vascular -- Adverse Effects
KW - Hospital Units
KW - Sepsis -- Epidemiology
KW - United States
SP - 290
EP - 301
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 35
IS - 5
CY - New York, New York
PB - Elsevier Science
SN - 0196-6553
AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA.
U2 - PMID: 17577475.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cooper, William O.
AU - Willy, Mary E.
AU - Pont, Stephen J.
AU - Ray, Wayne A.
T1 - Increasing use of antidepressants in pregnancy
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2007/06//
VL - 196
IS - 6
M3 - Article
SP - 544
EP - 544
SN - 00029378
AB - Objective: The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women. Study Design: This was a retrospective cohort study of 105,335 pregnancies among women enrolled in Tennessee Medicaid from 1999-2003. Pregnancies were classified according to antidepressant exposures during pregnancy using previously validated computerized pharmacy records linked with birth certificates. Results: During the study period, 8.7% of women giving birth had exposure to any antidepressant; 6.2% had exposure to a selective serotonin reuptake inhibitor. Maternal age > 25 years (P < .0001), white race (P < .0001), and education > 12 years (P = .008) were significant predictors of antidepressant exposure. The proportion of pregnancies with antidepressant use increased from 5.7% of pregnancies in 1999 to 13.4% of pregnancies in 2003 (p<.0001). The increase was mostly accounted for by increases in selective serotonin reuptake inhibitor exposures. Conclusion: There is an urgent need for further studies that better quantify the fetal consequences of exposure to antidepressants. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIDEPRESSANTS
KW - PREGNANCY
KW - SEROTONIN uptake inhibitors
KW - PREGNANT women
KW - WOMEN -- Health
KW - antidepressants
KW - fetal effects
KW - medication exposures
KW - pregnancy
N1 - Accession Number: 25278651; Cooper, William O. 1; Email Address: william.cooper@vanderbilt.edu; Willy, Mary E. 2; Pont, Stephen J. 1; Ray, Wayne A. 3; Source Information: Jun2007, Vol. 196 Issue 6, p544; Subject: ANTIDEPRESSANTS; Subject: PREGNANCY; Subject: SEROTONIN uptake inhibitors; Subject: PREGNANT women; Subject: WOMEN -- Health; Author-Supplied Keyword: antidepressants; Author-Supplied Keyword: fetal effects; Author-Supplied Keyword: medication exposures; Author-Supplied Keyword: pregnancy; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2007.01.033
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Higuchi, Shigekazu
AU - Motohashi, Yutaka
AU - Ishibashi, Keita
AU - Maeda, Takafumi
T1 - Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light.
JO - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
JF - American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
Y1 - 2007/06//
VL - 61
IS - 6
M3 - Article
SP - R2352
EP - R2356
SN - 03636119
AB - This experiment tested effects of human eye pigmentation depending on the ethnicity on suppression of nocturnal melatonin secretion by light. Ten healthy Caucasian males with blue, green, or light brown irises (light-eyed Caucasians) and 11 Asian males with dark brown irises (dark-eyed Asians) volunteered to participate in the study. The mean ages of the light-eyed Caucasians and dark-eyed Asians were 26.4 ± 3.2 and 25.3 ± 5.7 years, respectively. The subjects were exposed to light(1,000 lux) for 2 hat night. The starting time of exposure was set to 2 h before the time of peak salivary melatonin concentration of each subject, which was determined in a preliminary experiment. Salivary melatonin concentration and pupil size were measured before expo- sure to light and during exposure to light. The percentage of suppression of melatonin secretion by light was calculated. The percentage of suppression of melatonin secretion 2 h after the start of light exposure was significantly larger in light-eyed Caucasians (88.9 ± 4.2%) than in dark-eyed Asians (73.4 ± 20.0%) (P < 0.01). No significant difference was found between pupil sizes in light-eyed Caucasians and dark-eyed Asians. These results suggest that sensitivity of melatonin to light suppression is influenced by eye pigmentation and/or ethnicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Regulatory, Integrative & Comparative Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELATONIN
KW - ETHNICITY
KW - EYE color
KW - CAUCASIAN race
KW - ASIANS
KW - circadian rhythm
KW - ethnic
KW - iris
KW - pigmentation
KW - retina
N1 - Accession Number: 25643278; Higuchi, Shigekazu 1,2; Email Address: higuchi@hjniosh.go.jp Motohashi, Yutaka 1 Ishibashi, Keita 3 Maeda, Takafumi 4; Affiliation: 1: Department of Public Health, Akita University School of Medicine 2: National Institute of Occupational Safety and Health 3: Department of Human Living System Design, Faculty of Design, Kyushu University 4: Laboratory of Environmental Ergonomics, Graduate School of Engineering, Hokkaido University, Akita, Japan; Source Info: Jun2007, Vol. 61 Issue 6, pR2352; Subject Term: MELATONIN; Subject Term: ETHNICITY; Subject Term: EYE color; Subject Term: CAUCASIAN race; Subject Term: ASIANS; Author-Supplied Keyword: circadian rhythm; Author-Supplied Keyword: ethnic; Author-Supplied Keyword: iris; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: retina; Number of Pages: 5p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1152/ajpregu.00355.2006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biagini, Raymond E.
AU - Parks, Christine G.
AU - Smith, Jerome P.
AU - Sammons, Deborah L.
AU - Robertson, Shirley A.
T1 - Analytical performance of the AtheNA MultiLyte® ANA II assay in sera from lupus patients with multiple positive ANAs.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/06//
VL - 388
IS - 3
M3 - Article
SP - 613
EP - 618
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - The purpose of this study was to evaluate the precision and accuracy of a commercial multiplexed kit for the measurement of 9 anti-nuclear antibodies (ANAs; anti-SS/A, anti-SS/B, anti-Sm, anti-RNP, anti-Jo-1, anti-Scl-70, anti-dsDNA, anti-Centromere B, and anti-Histone), and to compare these results to a subset of ANAs measured by enzyme-linked immunosorbent assays (ELISA) and immunodiffusion (ID). Sera were obtained from 22 systemic lupus erythematosus (SLE) patients, twelve controls and five others (commercial source) with various autoimmune diseases. ANA results from the AtheNA MultiLyte® ANA II Assay (AtheNA) were compared to ELISA results (controls) and patients (ID). The AtheNA interassay coefficients of variation (CVs, N = 39, performed in duplicate; replicated 3×) ranged from 6.2% to 16.7% (mean = 9.8%), while the intra-assay CVs ranged from 5.8% to 14.3% (mean = 10.8%). Compared to results for SLE cases and controls, the sensitivity of AtheNA ranged from 85.7% to 100% (mean = 97.1%), while diagnostic specificity ranged from 16.7% to 100% (mean = 71.6%). There was significant agreement ( P values ranging from 0.0001 to 0.03) when analytes coanalyzed by AtheNA and ELISA/ID were evaluated using Cohen’s kappa ( κ values ranging from 0.376 to 1.000). No false positive ANA results were observed for either the control or commercial source autoimmune disease sera. These results indicate that the AtheNA assay is a precise and accurate alternative for performing multiple ELISAs or IDs in the diagnosis of autoimmune diseases, especially when the number of sera to be tested is large, such as in clinical screening or epidemiologic studies. It also appears that the AtheNA assay identifies positive ANA specificities which are missed by ID techniques, suggesting that it may have greater analytical sensitivity for some ANAs. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTINUCLEAR factors
KW - AUTOIMMUNE diseases
KW - SYSTEMIC lupus erythematosus
KW - ENZYME-linked immunosorbent assay
KW - AUTOANTIBODIES
KW - Antinuclear antibodies
KW - AtheNA MultiLyte® ANA system
KW - AtheNA MultiLyte® ANA system
KW - Autoimmune diseases
KW - ELISA
KW - Systemic lupus erythematosus
N1 - Accession Number: 24976595; Biagini, Raymond E. 1; Email Address: rbiagini@cdc.gov Parks, Christine G. 2 Smith, Jerome P. 1 Sammons, Deborah L. 1 Robertson, Shirley A. 1; Affiliation: 1: Biological Monitoring Research Team, Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Center for Disease Control and Prevention, CDC/NIOSH MS C 26, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Center for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Jun2007, Vol. 388 Issue 3, p613; Subject Term: ANTINUCLEAR factors; Subject Term: AUTOIMMUNE diseases; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: AUTOANTIBODIES; Author-Supplied Keyword: Antinuclear antibodies; Author-Supplied Keyword: AtheNA MultiLyte® ANA system; Author-Supplied Keyword: AtheNA MultiLyte® ANA system; Author-Supplied Keyword: Autoimmune diseases; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: Systemic lupus erythematosus; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1007/s00216-007-1243-x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lea, C. Suzanne
AU - Scotto, Joseph A.
AU - Buffler, Patricia A.
AU - Fine, Judith
AU - Barnhill, Raymond L.
AU - Berwick, Marianne
T1 - Ambient UVB and Melanoma Risk in the United States: A Case-Control Analysis
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2007/06//
VL - 17
IS - 6
M3 - Article
SP - 447
EP - 453
SN - 10472797
AB - Purpose: Exposure to ultraviolet-B (UVB) radiation is a well-established risk factor for human cutaneous malignant melanoma. Intermittent and cumulative exposures from UVB have been estimated most often by interview questionnaire. This study assessed cumulative UVB using a ground-based measurement instrument to estimate the association between UVB and melanoma. Methods: Population-based, incident cases of melanoma (n = 380) and frequency-matched controls (n = 364) residing in Connecticut at diagnosis were interviewed between 1987 and 1989 about recreational and vacation activities, sun-protection practices, occupation, and other factors. Using a residential history, regression estimates of lifetime UVB were derived from ambient measures of UVB, adjusted for intermittent exposure. Results: Cases and controls received 29% of lifetime mean UVB in the first 15 years of life. Number of days per year in recreational activity during childhood and late adulthood were associated with increased melanoma risk. When estimating lifetime UVB adjusted for intermittent exposure, melanoma risk peaked at a 5.7-fold increased risk in the ninth decile. Conclusion: Sporadic and chronic sun exposure play a role in melanoma etiology. Skin-protection practices should be encouraged across levels of sun intensity, not only in childhood but throughout adulthood. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANOMA
KW - ULTRAVIOLET radiation
KW - NEUROENDOCRINE tumors
KW - CHILDREN
KW - confidence interval ( CI )
KW - Epidemiology
KW - Exposure Assessment
KW - Malignant Melanoma
KW - minimum erythemal dose ( MED )
KW - odds ratio ( OR )
KW - Robertson–Berger ( RB )
KW - ultraviolet radiation ( UVR )
KW - ultraviolet radiation–B ( UVB )
KW - Ultraviolet Rays
N1 - Accession Number: 25186177; Lea, C. Suzanne; Email Address: SLea@rti.org Scotto, Joseph A. 1 Buffler, Patricia A. 1 Fine, Judith 1 Barnhill, Raymond L. 1 Berwick, Marianne 1; Affiliation: 1: From the Department of Epidemiology and Public Health Biology (C.S.L., P.A.B.), University of California, Berkeley, Berkeley, CA; U.S. Public Health Service (retired, Captain) (J.A.S.); Department of Surgery (J.F.), University of Connecticut Health Center , Farmington, CT; Department of Pathology, University of Miami School of Medicine, Miami, FL (R.L.B.); Cancer Research and Treatment Center, Department of Internal Medicine (M.B.), University of New Mexico, Albuquerque, NM; and Research Triangle Institute, International (C.S.L.), Research Triangle Park, NC; Source Info: Jun2007, Vol. 17 Issue 6, p447; Subject Term: MELANOMA; Subject Term: ULTRAVIOLET radiation; Subject Term: NEUROENDOCRINE tumors; Subject Term: CHILDREN; Author-Supplied Keyword: confidence interval ( CI ); Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Exposure Assessment; Author-Supplied Keyword: Malignant Melanoma; Author-Supplied Keyword: minimum erythemal dose ( MED ); Author-Supplied Keyword: odds ratio ( OR ); Author-Supplied Keyword: Robertson–Berger ( RB ); Author-Supplied Keyword: ultraviolet radiation ( UVR ); Author-Supplied Keyword: ultraviolet radiation–B ( UVB ); Author-Supplied Keyword: Ultraviolet Rays; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.annepidem.2007.01.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Timothy J.
AU - Wannemuehler, Yvonne M.
AU - Johnson, Sara J.
AU - Logue, Catherine M.
AU - White, David G.
AU - Doetkott, Curt
AU - Nolan, Lisa K.
T1 - Plasmid Replicon Typing of Commensal and Pathogenic Types of Escherichia coli Isolates.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/06//
VL - 73
IS - 11
M3 - Correction notice
SP - 3768
EP - 3768
SN - 00992240
AB - A correction to the article "Plasmid Replicon Typing of Commensal and Pathogenic Types of Escherichia Coli Isolates," published in the previous issue is presented.
KW - PATHOGENIC bacteria
N1 - Accession Number: 25350873; Johnson, Timothy J. 1,2,3 Wannemuehler, Yvonne M. 1,2,3 Johnson, Sara J. 1,2,3 Logue, Catherine M. 1,2,3 White, David G. 1,2,3 Doetkott, Curt 1,2,3 Nolan, Lisa K. 1,2,3; Affiliation: 1: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, 1802 Elwood Drive, VMRI #2, Iowa State University, Ames, Iowa 50011. 2: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, Maryland 20708. 3: Information Technology Services, North Dakota State University, Fargo, North Dakota 58105.; Source Info: Jun2007, Vol. 73 Issue 11, p3768; Subject Term: PATHOGENIC bacteria; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1128/AEM.00760-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Brent A.
AU - Geronilla, Ken B.
AU - Cutlip, Robert G.
AU - Kashon, Michael L.
AU - Wu, John Z.
T1 - The influence of velocity of stretch–shortening contractions on muscle performance during chronic exposure: age effects.
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
Y1 - 2007/06//
VL - 32
IS - 3
M3 - Article
SP - 443
EP - 453
PB - Canadian Science Publishing
SN - 17155312
AB - Aging increases injury susceptibility and impairs the ability to adapt to repetitive exposures of mechanical loading. The objective of this research was to investigate if movement velocity affects muscle response to a chronic administration of stretch–shortening cycles (SSCs) differently in young vs. old rats. Dorsiflexor muscles of old (30 months, n = 5) and young rats (12 weeks, n = 6) were exposed 3 times/week for 4.5 weeks to a protocol of 80 maximal SSCs per exposure in vivo. Skeletal muscle response was characterized by high- (500°/s) and low- (60°/s) velocity dynamic performance, which was evaluated using peak eccentric force, isometric pre-stretch force, eccentric force enhancement above the isometric pre-stretch force, negative work, and positive work. The performance of the young and old groups was not statistically different at the start of the exposure. By the end of the exposure, however, a statistical difference was noted—performance increased significantly in the young animals and decreased significantly in the old animals. The SSC velocity had a profound effect on muscle response. The young animals’ high- and low-velocity performances increased during the chronic exposure period, whereas the old animals’ performances declined. High-velocity performance increased more than low-velocity performance in young animals. In contrast, old animals suffered the most loss in high-velocity performance over the chronic exposure period. A chronic exposure of SSCs results in a significant performance increase in young animals, and a significant performance decrease in old animals. These differences are more profound during high-velocity movements. These findings suggest that age may impair the ability of skeletal muscle to adapt to repetitive mechanical loading, particularly during high-velocity movements. (English) [ABSTRACT FROM AUTHOR]
AB - Le vieillissement augmente le risque de blessures et réduit l’aptitude à s’adapter aux séances répétées de mise en charge. Le but de cette étude est de vérifier si la vélocité de mouvement suscite la même réponse musculaire selon l’âge chez des rats jeunes et âgés à la suite d’une administration chronique d’actions d’étirement–contraction (SSCs) du muscle. Durant 4,5 semaines à raison de 3 fois par semaine, on administre in vivo une série de 80 SSCs maximales aux fléchisseurs dorsaux de jeunes rats (12 semaines, n = 6) et de rats plus âgés (30 mois, n = 5). La réponse du muscle squelettique, caractérisée par sa performance dynamique à faible (60°/s) et à haute vélocité (500°/s), est évaluée par la force pliométrique de pointe, la force isométrique précédant l’étirement, le surplus de force pliométrique observé au-delà de la force isométrique précédant l’étirement, le travail négatif et le travail positif. Au début de la séance, la performance des jeunes rats ne diffère pas statistiquement de celles des rats âgés. Vers la fin de la séance, on observe une différence statistiquement significative : la performance des jeunes rats augmente significativement et celle des rats âgés diminue significativement. La vélocité de l’action d’étirement–contraction a un effet marqué sur la réponse. La performance à basse et à haute vélocité des jeunes rats augmente au cours de la séance d’administration chronique des actions d’étirement–contraction et celle des rats âgés diminue. Chez les jeunes rats, la performance à haute vélocité augmente plus que celle à basse vélocité. En contrepartie, on observe chez les rats plus âgés une plus grande diminution de la performance à haute vélocité que celle observée à basse vélocité au cours de la séance d’administration chronique d’actions d’étirement–contraction. Une séance d’administration chronique d’actions d’étirement–contraction cause une augmentation significative de la performance chez les jeunes rats et une diminution significative chez les rats plus âgés. Ces différences sont plus importantes au cours de mouvements exécutés à haute vélocité. Ces observations laissent entendre que le vieillissement peut réduire l’aptitude du muscle squelettique à s’adapter à une mise en charge répétitive, et ce, particulièrement au cours de mouvements exécutés à haute vélocité. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Physiology, Nutrition & Metabolism is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGE factors in disease
KW - MUSCLE contraction
KW - WOUNDS & injuries
KW - AGING
KW - MUSCLES -- Motility
KW - chronic exposure
KW - in vivo dynamometry
KW - skeletal muscle
KW - SSCs
KW - actions d'étirement-contraction
KW - dynamométrie in vivo
KW - exposition répétée
KW - muscle squelettique
N1 - Accession Number: 25479920; Baker, Brent A. 1 Geronilla, Ken B. 1 Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov Kashon, Michael L. 1 Wu, John Z. 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA; Source Info: Jun2007, Vol. 32 Issue 3, p443; Subject Term: AGE factors in disease; Subject Term: MUSCLE contraction; Subject Term: WOUNDS & injuries; Subject Term: AGING; Subject Term: MUSCLES -- Motility; Author-Supplied Keyword: chronic exposure; Author-Supplied Keyword: in vivo dynamometry; Author-Supplied Keyword: skeletal muscle; Author-Supplied Keyword: SSCs; Author-Supplied Keyword: actions d'étirement-contraction; Author-Supplied Keyword: dynamométrie in vivo; Author-Supplied Keyword: exposition répétée; Author-Supplied Keyword: muscle squelettique; Language of Keywords: English; Language of Keywords: French; Number of Pages: 10p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1139/H07-014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106168863
T1 - The influence of velocity of stretch-shortening contractions on muscle performance during chronic exposure: age effects.
AU - Cutlip RG
AU - Baker BA
AU - Geronilla KB
AU - Kashon ML
AU - Wu JZ
Y1 - 2007/06//
N1 - Accession Number: 106168863. Language: English. Entry Date: 20071012. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts; tracings. Journal Subset: Biomedical; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. Special Interest: Nutrition; Sports Medicine. NLM UID: 101264333.
KW - Aging -- Physiology
KW - Muscle Contraction -- Physiology
KW - Muscle, Skeletal -- Physiology
KW - Animal Studies
KW - Biomechanics
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Dynamometry
KW - Electric Stimulation
KW - Experimental Studies
KW - Male
KW - Rats
KW - Weight-Bearing -- Physiology
SP - 443
EP - 453
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
JA - APPL PHYSIOL NUTR METAB
VL - 32
IS - 3
CY - Ottawa, Ontario
PB - Canadian Science Publishing
SN - 1715-5312
AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26506, USA. rgc8@cdc.gov
U2 - PMID: 17510679.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106168863&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schulz, Timothy A.
AU - Prinz, William A.
T1 - Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family
JO - BBA - Molecular & Cell Biology of Lipids
JF - BBA - Molecular & Cell Biology of Lipids
Y1 - 2007/06//
VL - 1771
IS - 6
M3 - Article
SP - 769
EP - 780
SN - 13881981
AB - Abstract: Sterols such as cholesterol are a significant component of eukaryotic cellular membranes, and their unique physical properties influence a wide variety of membrane processes. It is known that the concentration of sterol within the membrane varies widely between organelles, and that the cell actively maintains this distribution through various transport processes. Vesicular pathways such as secretion or endocytosis may account for this traffic, but increasing evidence highlights the importance of nonvesicular routes as well. The structure of an oxysterol-binding protein homologue (OSH) in yeast (Osh4p/Kes1p) has recently been solved, identifying it as a sterol binding protein, and there is evidence consistent with the role of a cytoplasmic, nonvesicular sterol transporter. Yeast have seven such proteins, which appear to have distinct but overlapping functions with regard to maintaining intracellular sterol distribution and homeostasis. Control of sterol distribution can have far-reaching effects on membrane-related functions, and Osh proteins have been implicated in a variety of processes such as secretory vesicle budding from the Golgi and establishment of cell polarity. This review summarizes the current body of knowledge regarding this family and its potential functions, placing it in the context of known and hypothesized pathways of sterol transport in yeast. [Copyright &y& Elsevier]
AB - Copyright of BBA - Molecular & Cell Biology of Lipids is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEAVENING agents
KW - BIOLOGICAL transport
KW - PHYSIOLOGY
KW - ABSORPTION (Physiology)
KW - Lipid
KW - Lipid binding protein
KW - Membrane transport
KW - Oxysterol binding protein
KW - Sterol
KW - Yeast
N1 - Accession Number: 25322073; Schulz, Timothy A. 1 Prinz, William A.; Email Address: wprinz@helix.nih.gov; Affiliation: 1: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Jun2007, Vol. 1771 Issue 6, p769; Subject Term: LEAVENING agents; Subject Term: BIOLOGICAL transport; Subject Term: PHYSIOLOGY; Subject Term: ABSORPTION (Physiology); Author-Supplied Keyword: Lipid; Author-Supplied Keyword: Lipid binding protein; Author-Supplied Keyword: Membrane transport; Author-Supplied Keyword: Oxysterol binding protein; Author-Supplied Keyword: Sterol; Author-Supplied Keyword: Yeast; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bbalip.2007.03.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105984940
T1 - Lemierre's syndrome in association with a cholesteatoma.
AU - Healy B
AU - Llewelyn M
AU - Cavalle F
AU - Bernard M
Y1 - 2007/06//2007 Jun
N1 - Accession Number: 105984940. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101257109.
KW - Cholesteatoma -- Microbiology
KW - Gram-Negative Bacteria
KW - Lemierre Syndrome -- Complications
KW - Adolescence
KW - Magnetic Resonance Imaging
KW - Male
SP - 330
EP - 331
JO - British Journal of Hospital Medicine (17508460)
JF - British Journal of Hospital Medicine (17508460)
JA - BR J HOSP MED (LOND)
VL - 68
IS - 6
PB - Mark Allen Holdings Limited
SN - 1750-8460
AD - Specialist Registrar in Microbiology, Microbiology Dept, National Public Health Service, University Hospital of Wales, Cardiff CF14 4XW
U2 - PMID: 17639838.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Derrick, Steven C.
AU - Morris, Sheldon L.
T1 - The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression.
JO - Cellular Microbiology
JF - Cellular Microbiology
Y1 - 2007/06//
VL - 9
IS - 6
M3 - Article
SP - 1547
EP - 1555
PB - Wiley-Blackwell
SN - 14625814
AB - The secreted Mycobacterium tuberculosis protein, ESAT6, has been studied extensively in pathogenicity and vaccine experiments. Despite these studies little is known about the function of this protein. In this report, we demonstrate that ESAT6 induces apoptosis in THP-1 human macrophages using fluorescein isothiocyanate-Annexin V and intracellular caspase staining. We show that the induction of apoptosis by ESAT6 is dependent on the dose of the protein and the expression of caspase genes. Using real-time RT-PCR, we found that expression of caspase-1, -3, -5, -7 and -8 genes was upregulated in cells treated with ESAT6 relative to untreated cells. Furthermore, we show that while infection of THP-1 cells with wild-type M. tuberculosis strain H37Rv resulted in significant apoptosis 48 h post infection, a deletion mutant that does not express ESAT6 failed to induce significant apoptosis. Finally, experimental results using a cell impermeable fluorescent stain suggests that the formation of membrane pores may be a primary mechanism by which ESAT6 evokes an apoptotic response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM tuberculosis
KW - VIRUS diseases -- Vaccination
KW - APOPTOSIS
KW - MACROPHAGE activation
KW - POLYMERASE chain reaction
N1 - Accession Number: 25053826; Derrick, Steven C. 1; Email Address: steven.derrick@fda.hhs.gov Morris, Sheldon L. 1; Affiliation: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jun2007, Vol. 9 Issue 6, p1547; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: VIRUS diseases -- Vaccination; Subject Term: APOPTOSIS; Subject Term: MACROPHAGE activation; Subject Term: POLYMERASE chain reaction; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1462-5822.2007.00892.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huiquan Wu
AU - Khan, Mansoor A.
AU - Hussain, Ajaz S.
T1 - PROCESS CONTROL PERSPECTIVE FOR PROCESS ANALYTICAL TECHNOLOGY: INTEGRATION OF CHEMICAL ENGINEERING PRACTICE INTO SEMICONDUCTOR AND PHARMACEUTICAL INDUSTRIES.
JO - Chemical Engineering Communications
JF - Chemical Engineering Communications
Y1 - 2007/06//
VL - 194
IS - 6
M3 - Article
SP - 760
EP - 779
PB - Taylor & Francis Ltd
SN - 00986445
AB - FDA's Process Analytical Technology (PAT) initiative provides an unprecedented opportunity for chemical engineers to play significant roles in the pharmaceutical industry. In this article, the authors provide their perspectives on (1) the need for chemical engineering principles in pharmaceutical development for a thorough process understanding; (2) applications of chemical engineering principles to meet the challenges from the semiconductor and pharmaceutical industries; and (3) the integration of chemical engineering practice into the semiconductor and pharmaceutical industries to achieve process understanding and the desired state of quality-by-design. A real-world case study from the semiconductor industry is presented to demonstrate how a classic chemical engineering concept, mixing homogeneity, can be implemented by inducing forced flow to ensure an excellent copper electrochemical plating process performance and to improve product quality substantially. Further, a case study of brake system design is discussed with the concept of Dr. Taguchi's robust engineering design to illustrate how quality-by-design can be achieved through appropriate experimental design, in conjunction with the discussion on the concept of quality-by-design in pharmaceuticals. Third, a case study of freeze-dried sodium ethacrynate is presented to demonstrate the vital importance of controlling the processing factors to achieve the desired product stability. Finally, the problems of the current pharmaceutical manufacturing mode, the opportunities and engineering challenges during implementation of PAT in the pharmaceutical industry, and the role of chemical engineering in implementation of PAT is discussed in detail. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Engineering Communications is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROCESS control
KW - AUTOMATIC control
KW - PHARMACEUTICAL industry
KW - SEMICONDUCTOR industry
KW - PHARMACEUTICAL services
KW - CHEMICAL engineering
KW - Chemical engineering principles
KW - On-line process control
KW - Process Analytical Technology (PAT)
KW - Quality-by-design
KW - Taguchi robust engineering design
N1 - Accession Number: 24233151; Huiquan Wu 1; Email Address: huiquan.wu@fda.hhs.gov Khan, Mansoor A. 1 Hussain, Ajaz S. 2; Affiliation: 1: Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 2: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland; Source Info: Jun2007, Vol. 194 Issue 6, p760; Subject Term: PROCESS control; Subject Term: AUTOMATIC control; Subject Term: PHARMACEUTICAL industry; Subject Term: SEMICONDUCTOR industry; Subject Term: PHARMACEUTICAL services; Subject Term: CHEMICAL engineering; Author-Supplied Keyword: Chemical engineering principles; Author-Supplied Keyword: On-line process control; Author-Supplied Keyword: Process Analytical Technology (PAT); Author-Supplied Keyword: Quality-by-design; Author-Supplied Keyword: Taguchi robust engineering design; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 334413 Semiconductor and Related Device Manufacturing; Number of Pages: 20p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1080/00986440601098755
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Cheever, Laura W.
T1 - Engaging HIV-Infected Patients in Care: Their Lives Depend on It.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/06//6/1/2007
VL - 44
IS - 11
M3 - Editorial
SP - 1500
EP - 1502
SN - 10584838
AB - The article presents the comments of the author on the guidelines issued by the U.S. Centers for Disease Control and Prevention for HIV testing which encourages medical providers to make HIV testing routine. These guidelines intend to improve the identification of infected individuals and to retain these individuals in HIV care.
KW - Guidelines
KW - Medical screening
KW - HIV-positive persons
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 25113855; Cheever, Laura W. 1; Email Address: lcheever@hrsa.gov; Affiliations: 1: Department of Health and Human Services, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Maryland.; Issue Info: 6/1/2007, Vol. 44 Issue 11, p1500; Subject Term: Guidelines; Subject Term: Medical screening; Subject Term: HIV-positive persons; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1086/517534
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25113855&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Cheever, Laura W.
T1 - Engaging HIV-Infected Patients in Care: Their Lives Depend on It.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/06//6/1/2007
VL - 44
IS - 11
M3 - Editorial
SP - 1500
EP - 1502
SN - 10584838
AB - The article presents the comments of the author on the guidelines issued by the U.S. Centers for Disease Control and Prevention for HIV testing which encourages medical providers to make HIV testing routine. These guidelines intend to improve the identification of infected individuals and to retain these individuals in HIV care.
KW - GUIDELINES
KW - MEDICAL screening
KW - HIV-positive persons
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 25113855; Cheever, Laura W. 1; Email Address: lcheever@hrsa.gov; Affiliation: 1: Department of Health and Human Services, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Maryland.; Source Info: 6/1/2007, Vol. 44 Issue 11, p1500; Subject Term: GUIDELINES; Subject Term: MEDICAL screening; Subject Term: HIV-positive persons; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1086/517534
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nayak, Rajesh
AU - Call, Veronica
AU - Kaldhone, Pravin
AU - Tyler, Cynthia
AU - Anderson, Gwendolyn
AU - Phillips, Sarah
AU - Kerdahi, Khalil
AU - Foley, Steven L.
T1 - Comparison of Salmonella enterica serovar Heidelberg Susceptibility Testing Results.
JO - Clinical Medicine & Research
JF - Clinical Medicine & Research
Y1 - 2007/06//
VL - 5
IS - 2
M3 - Article
SP - 98
EP - 105
PB - Marshfield Clinic
SN - 15394182
AB - Objective: Disk diffusion and broth dilution assays are conventionally used for antimicrobial susceptibility testing (AST) of bacteria. The goal of this study was to determine the correlation of results from different AST methods for the Salmonella enterica serovar Heidelberg. Design: S. enterica serovar Heidelberg (n=105) strains were tested using 4 different AST methods: agar disk diffusion, broth microdilution using Sensititre with the NARMS (CMV1AGNF) panel, manual broth microdilution and Vitek with GNS-207 cards. Methods: AST was performed using standardized methods and Clinical and Laboratory Standards Institute recommended quality control organisms. Eight drugs were common to all testing methods including amikacin, amoxicillin/clavulanic acid, ampicillin, chloramphenicol, ciprofloxacin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole. Results: No resistance to amikacin and ciprofloxacin was detected. Overall, the agreement of the AST results among all four methods for the drugs tested was: amikacin (100%), amoxicillin/clavulanic acid (96.1%), ampicillin (97.1%), chloramphenicol (96.2%), ciprofloxacin (100%), gentamicin (80.0%), tetracycline (80.0%) and trimethoprim/sulfamethoxazole (94.3%).There was 97.1%, 95.5% and 98.0% overall agreement between the reference diffusion method and the manual broth microdilution, Sensititre microdilution and Vitek methods, respectively. Conclusion: The study indicated that AST methods correlated with one another when testing S. enterica serovar Heidelberg isolates, with a few exceptions. In general, discrepancies among the methods were due to isolates being interpreted as intermediately susceptible or due to an increased number of resistances detected with Sensititre and a lower number with Vitek. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Medicine & Research is the property of Marshfield Clinic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIAL sensitivity tests
KW - SALMONELLA
KW - EFFECT of antibiotics on microorganisms
KW - EFFECT of drugs on microorganisms
KW - AMOXICILLIN
KW - CHLORAMPHENICOL
KW - TRIMETHOPRIM
KW - Antimicrobial susceptibility testing
KW - Broth microdilution
KW - Disk diffusion
KW - Salmonella enterica serotype Heidelberg
N1 - Accession Number: 25887487; Nayak, Rajesh 1 Call, Veronica 2 Kaldhone, Pravin 3 Tyler, Cynthia 3 Anderson, Gwendolyn 2 Phillips, Sarah 2 Kerdahi, Khalil 2 Foley, Steven L. 2,3; Email Address: foley.steven@mcrf.mfldclin.edu; Affiliation: 1: National Center for Toxicological Research United States Food and Drug Administration Jefferson, Arkansas 2: Office of Regulatory Affairs/Arkansas Regional Laboratory United States Food and Drug Administration Jefferson, Arkansas 3: National Farm Medicine Center Marshfield Clinic Research Foundation Marshfield, Wisconsin, Department of Biology University of Central Arkansas Conway, Arkansas; Source Info: Jun2007, Vol. 5 Issue 2, p98; Subject Term: MICROBIAL sensitivity tests; Subject Term: SALMONELLA; Subject Term: EFFECT of antibiotics on microorganisms; Subject Term: EFFECT of drugs on microorganisms; Subject Term: AMOXICILLIN; Subject Term: CHLORAMPHENICOL; Subject Term: TRIMETHOPRIM; Author-Supplied Keyword: Antimicrobial susceptibility testing; Author-Supplied Keyword: Broth microdilution; Author-Supplied Keyword: Disk diffusion; Author-Supplied Keyword: Salmonella enterica serotype Heidelberg; Number of Pages: 8p; Document Type: Article
L3 - 10.3121/cmr.2007.725
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tammara, Vijay
AU - Jacobson-Kram, David
T1 - Exploratory Investigational New Drug (IND) Studies in Humans.
JO - Clinical Research & Regulatory Affairs
JF - Clinical Research & Regulatory Affairs
Y1 - 2007/06//
VL - 24
IS - 2-4
M3 - Article
SP - 77
EP - 86
PB - Taylor & Francis Ltd
SN - 10601333
AB - In recent years drug development costs have escalated despite the fact that new technology is evolving and the development process has accelerated. This is due in part to the extremely high failure rate of drugs at early phases of drug development. Efforts are underway within the pharmaceutical industry to shift this attrition rate to early stages of drug development rather than at late stages. To this end, the exploratory IND approach is considered as one of the tools in a new drug development "tool box," to distinguish earlier in the process those candidates that hold promise from those that do not. The phrase exploratory IND study is intended to describe a clinical trial that is conducted early in phase 1, involves very limited human exposure, has no therapeutic or diagnostic intent (e.g., screening studies, microdose studies), and is NOT intended to establish a maximally tolerated dose (MTD). In this article, authors attempt to summarize the goals of eIND, a brief description of eIND requirements, and limitations of an eIND. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Research & Regulatory Affairs is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - PHARMACOLOGY
KW - DOSAGE of drugs
KW - DRUGS -- Dose-response relationship
KW - PHARMACEUTICAL industry
N1 - Accession Number: 27835054; Tammara, Vijay 1; Email Address: vijay-tammara@merck.com Jacobson-Kram, David 2; Affiliation: 1: Regulatory Affairs, Merck & Co., Inc., North Wales, Pennsylvania, USA 2: Office of New Drugs, CDER, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Jun2007, Vol. 24 Issue 2-4, p77; Subject Term: DRUG development; Subject Term: PHARMACOLOGY; Subject Term: DOSAGE of drugs; Subject Term: DRUGS -- Dose-response relationship; Subject Term: PHARMACEUTICAL industry; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1080/10601330701683412
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106129752
T1 - Patient handling tasks with high risk for musculoskeletal disorders in critical care.
AU - Waters TR
AU - Nelson A
AU - Proctor C
Y1 - 2007/06//2007 Jun
N1 - Accession Number: 106129752. Language: English. Entry Date: 20070803. Revision Date: 20150819. Publication Type: Journal Article; algorithm; equations & formulas; forms; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 8912620.
KW - Critical Care Nursing
KW - Ergonomics
KW - Lifting -- Adverse Effects
KW - Lifting -- Methods
KW - Musculoskeletal Diseases -- Etiology
KW - Musculoskeletal Diseases -- Risk Factors
KW - Nursing Care -- Methods
KW - Occupational Safety -- Methods
KW - Occupational-Related Injuries -- Etiology
KW - Occupational-Related Injuries -- Prevention and Control
KW - Patient Positioning -- Methods
KW - Patient Positioning -- Nursing
KW - Transfer Techniques -- Methods
KW - Transfer Techniques -- Nursing
KW - Bedmaking -- Methods
KW - Compression Garments -- Nursing
KW - Compression Garments -- Utilization
KW - Decision Trees
KW - Nursing Staff, Hospital
SP - 131
EP - 143
JO - Critical Care Nursing Clinics of North America
JF - Critical Care Nursing Clinics of North America
JA - CRIT CARE NURS CLIN NORTH AM
VL - 19
IS - 2
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Critical care nurses are at high risk for development of work-related musculoskeletal disorders (WMSDs). Many patient handling tasks in critical care require physical demands that may result in excessive internal forces, increasing the risk for WMSDs. There are solutions for performing these tasks safely, using technology. This article describes risk factors associated with high-risk patient handling tasks and presents solutions for reducing risk for WMSDs. Studies show that implementing a safe patient handling and movement program that incorporates new technology can pay for itself in a short period of time and provide long-term benefit for health care facilities and nursing staff. Copyright © 2007 by Elsevier Inc.
SN - 0899-5885
AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway (MS-C24), Cincinnati, OH 45226, USA.
U2 - PMID: 17512469.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Funnell, Martha M.
AU - Brown, Tammy L.
AU - Childs, Belinda P.
AU - Haas, Linda B.
AU - Hosey, Gwen M.
AU - Jensen, Brian
AU - Maryniuk, Melinda
AU - Peyrot, Mark
AU - Piette, John D.
AU - Reader, Diane
AU - Siminerio, Linda M.
AU - Weinger, Katie
AU - Weiss, Michael A.
T1 - National Standards for Diabetes Self-Management Education.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2007/06//
VL - 30
IS - 6
M3 - Article
SP - 1630
EP - 1637
SN - 01495992
AB - The article presents information on the national standards for diabetes self-management education (DSME). It stresses the importance of the DSME to people with diabetes and its necessity in order to improve patient outcomes. The standards are said to be designed to define quality diabetes self-management education and to assist diabetes educators to provide evidence-based education. It cites the objectives and the overriding principles that would be used for the revision of the said standards.
KW - GUIDELINES
KW - DIABETES
KW - DIABETICS
KW - DISEASE management
KW - PATIENT education
N1 - Accession Number: 25624216; Funnell, Martha M. 1; Email Address: mfunnell@umich.edu Brown, Tammy L. 2 Childs, Belinda P. 3 Haas, Linda B. 4 Hosey, Gwen M. 5 Jensen, Brian 6 Maryniuk, Melinda 7 Peyrot, Mark 8 Piette, John D. 9,10 Reader, Diane 11 Siminerio, Linda M. 12 Weinger, Katie 7 Weiss, Michael A. 13; Affiliation: 1: Department of Medical Education, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 2: Indian Health Service, Albuquerque, New Mexico 3: MidAmerica Diabetes Associates, Wichita, Kansas 4: VA Puget Sound Health Care System, Seattle, Washington 5: Division of Diabetes Translation, National Center for Chronic Diseases Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 6: Lakeshore Apothacare, Two Rivers, Wisconsin 7: Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 8: Loyola College, Baltimore, Maryland 9: VA Ann Arbor Health Care System, Ann Arbor, Michigan 10: Department of Internal Medicine, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 11: International Diabetes Center, Minneapolis, Minnesota 12: Diabetes Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 13: Patient Centered Solutions, Pittsburgh, Pennsylvania; Source Info: Jun2007, Vol. 30 Issue 6, p1630; Subject Term: GUIDELINES; Subject Term: DIABETES; Subject Term: DIABETICS; Subject Term: DISEASE management; Subject Term: PATIENT education; Number of Pages: 8p; Document Type: Article; Full Text Word Count: 7896
L3 - 10.2337/dc07-9923
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bányai, Krisztián
AU - Bogdán, Ágnes
AU - Kisfali, Péter
AU - Molnár, Péter
AU - Mihály, Ilona
AU - Melegh, Béla
AU - Martella, Vito
AU - Gentsch, Jon R.
AU - Szücs, György
T1 - Emergence of Serotype G12 Rotaviruses, Hungary.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/06//
VL - 13
IS - 6
M3 - Article
SP - 916
EP - 919
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We describe the emergence of serotype G12 rotaviruses (67 [6.9%] of 971 specimens tested) among children hospitalized with rotavirus gastroenteritis in Hungary during 2005. These findings are consistent with recent reports of the possible global spread and increasing epidemiologic importance of these strains, which may have implications for current rotavirus vaccination strategies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - VACCINATION
KW - Rotaviruses
KW - Gastroenteritis in children
KW - Gastroenteritis
KW - Rotavirus diseases
KW - Hungary
N1 - Accession Number: 25357143; Bányai, Krisztián 1,2; Email Address: bkrota@hotmail.com; Bogdán, Ágnes 1; Kisfali, Péter 2; Molnár, Péter 3; Mihály, Ilona 3; Melegh, Béla 2; Martella, Vito 4; Gentsch, Jon R. 5; Szücs, György 1,2; Affiliations: 1: Baranya County Institute of State Public Health Service, Pécs, Hungary; 2: University of Pécs, Hungary; 3: "St. Laszlo" Central Hospital for Infectious Diseases, Budapest, Hungary; 4: University of Bari, Bari, Italy; 5: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; Issue Info: Jun2007, Vol. 13 Issue 6, p916; Thesaurus Term: Epidemiology; Thesaurus Term: VACCINATION; Subject Term: Rotaviruses; Subject Term: Gastroenteritis in children; Subject Term: Gastroenteritis; Subject Term: Rotavirus diseases; Subject: Hungary; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kerry L. Dearfield
AU - James C. Fuscoe
T1 - Impact of genomic technologies on regulatory policiesâPresentations at the 37th annual meeting of the Environmental Mutagen SocietyThis manuscript represents the views of the authors. The contents do not necessarily reflect the views or policies of their agencies, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/06//
VL - 48
IS - 5
M3 - Article
SP - 347
EP - 348
SN - 08936692
N1 - Accession Number: 25509296; Kerry L. Dearfield 1; James C. Fuscoe 2; Affiliations: 1: U.S. Department of Agriculture, Food Safety and Inspection Service, Office of Public Health Science, Washington, District of Columbia; 2: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of System Toxicology, Jefferson, Arkansas; Issue Info: Jun2007, Vol. 48 Issue 5, p347; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - James C. Fuscoe
AU - Weida Tong
AU - Leming Shi
T1 - QA/QC issues to aid regulatory acceptance of microarray gene expression dataThis article is a US Government work and, as such, is in the public domain in the United States of America.This article is based on a presentation given at âImpact of Genomic Technologies on Regulatory Policies,â 37th Annual Meeting of the Environmental Mutagen Society, September 18, 2006, Vancouver, Canada.The views expressed in this article are those of the authors and not necessarily those of the U.S. Food and Drug Administration.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/06//
VL - 48
IS - 5
M3 - Article
SP - 349
EP - 353
SN - 08936692
AB - The U.S. Food and Drug Administration is responsible for (1) promoting and protecting public health by assuring the safety and effectiveness of medicines and medical devices and (2) advancing public health by helping to speed innovations that make medicines and foods safer, more effective, and more affordable. The genomics revolution has dramatically increased our knowledge of basic biology but this has not resulted in the expected acceleration of new medical product development. The Agency's Critical Path to New Medical Products stresses that new tools are needed to address this pipeline problem. Microarray technology is one of these promising tools although questions have risen about the reproducibility of measurements. The Microarray Quality Control (MAQC) Project was initiated by FDA scientists to address this issue. This large project, which evaluated reference RNA samples on seven microarray platforms, found good intralaboratory repeatability and interlaboratory reproducibility. In addition, there was high crossâplatform consistency. All data are available free of cost and the reference RNA samples are available for proficiency testing. Thus, current microarray technology appears to provide both reliability and consistency for regulatory submissions. Environ. Mol. Mutagen. 48:349â353, 2007. Published 2007 WileyâLiss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Molecular Mutagenesis is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genomics
KW - Gene expression
KW - Quality control
KW - United States. Food & Drug Administration
N1 - Accession Number: 25509288; James C. Fuscoe 1; Weida Tong 2; Leming Shi 2; Affiliations: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; 2: Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; Issue Info: Jun2007, Vol. 48 Issue 5, p349; Subject Term: Genomics; Subject Term: Gene expression; Subject Term: Quality control ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Federico Goodsaid
AU - Felix W. Frueh
T1 - Implementing the U.S. FDA guidance on pharmacogenomic data submissionsThis article is a US Government work and, as such, is in the public domain in the United States of America.Views expressed in this manuscript are those of the authors and not necessarily those of the U.S. Food and Drug Administration.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/06//
VL - 48
IS - 5
M3 - Article
SP - 354
EP - 358
SN - 08936692
AB - The FDA Guidance for Industry: Pharmacogenomics Data Submissions was issued in 2005. This guidance document covers a broad area associated with how and when to submit genomic data to the FDA. Additional tasks associated with genomic data submissions include the implementation of genomic data submissions; the process for qualification of exploratory biomarkers into valid biomarkers; and technical recommendations for the generation and submission of genomic data to the FDA. These tasks have been addressed throughout the past 2 years by a number of initiatives. These initiatives have included the development of the Interdisciplinary Pharmacogenomics Review Group for review of pharmacogenomic data submissions, the pilot process for qualification of biomarkers, and the concept paper on recommendations for the generation and submission of genomic data. These initiatives have contributed to the effective implementation of the Pharmacogenomics Guidance at the FDA. Environ. Mol. Mutagen. 48:354â358, Published 2007 WileyâLiss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Molecular Mutagenesis is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacogenomics
KW - Genomics
KW - United States. Food & Drug Administration
N1 - Accession Number: 25509289; Federico Goodsaid 1; Felix W. Frueh 1; Affiliations: 1: Genomics Group, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20903â0002; Issue Info: Jun2007, Vol. 48 Issue 5, p354; Subject Term: Pharmacogenomics; Subject Term: Genomics ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Ena
AU - Mee Young Ahn
AU - Hee Jin Kim
AU - In Young Kim
AU - Soon Young Han
AU - Tae Seok Kang
AU - Jin Hwan Hong
AU - Kui Lea Park
AU - Byung Mu Lee
AU - Hyung Sik Kim
T1 - Effect of Di(n-butyl) Phthalate on Testicular Oxidative Damage and Antioxidant Enzymes in Hyperthyroid Rats.
JO - Environmental Toxicology
JF - Environmental Toxicology
Y1 - 2007/06//
VL - 22
IS - 3
M3 - Article
SP - 245
EP - 255
SN - 15204081
AB - This study compared the effects of di(n-butyl) phthalate (DBP) on the oxidative damage and antioxidant enzymes activity in testes of hyperthyroid rats. Hyperthyroidism was induced in pubertal male rats by intraperitoneal injection of triiodothyronine (T3, 10 µg/kg body weight) for 30 days. An oral dose of DBP (750 mg/kg) was administered simultaneously to normal or hyperthyroid (T3) rats over a 30-day period. No changes in body weight were observed in the hyperthyroid groups (T3, T3 + DBP) compared with controls. There were significantly higher serum T3 levels observed in the hyperthyroid rats than in the control, but the serum thyroid stimulating hormone levels were markedly lower in the hyperthyroid rats. DBP significantly decreased the weight of the testes in the normal (DBP) and hyperthyroid (T3 + DBP) groups, The serum testosterone concentrations were significantly lower in only DBP group. DBP significantly increased the 8-hydroxy-2-deoxyguanosine (8-OHdG) level in the testes, whereas the DBP-induced 8- OHdG levels were slightly higher in T3 + DBP group. Superoxide dismutase and glutathione peroxidase activities were significantly higher in the testes of the DBP or T3 + DBP groups. Catalase (CAT) activity was significantly higher in the DBP treatment group, but the T3 + DBP group showed slightly lower DBP-induced CAT activity. The testicular expression of thyroid hormone receptor α-1 (TRα-I) was significantly higher in the DBP groups, and androgen receptor (AR) expression was not detected in the DBP treatment group. In addition, DBP significantly increased the peroxisome proliferator-activated receptor-r (PPAR-r) levels in the testis. These results suggest that hyperthyroidism can cause a change in the expression level of PPAR-r in testes, and may increase the levels of oxidative damage induced by the metabolic activation of DBP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Biotransformation (Metabolism)
KW - Hyperthyroidism
KW - Thyroid diseases
KW - Rats
KW - Thyroid hormones
KW - Malondialdehyde
KW - Catalase
KW - Superoxide dismutase
KW - Peroxisomes
KW - Male reproductive organs
KW - 8-hydroxy-2-deoxyguanosine
KW - catalase
KW - di(n-butyl) phthalate
KW - glutathione peroxidase
KW - malondialdehyde
KW - peroxisome proliferator-activated receptor
KW - superoxide dismutase
KW - thyroid hormone
N1 - Accession Number: 25267968; Lee, Ena 1; Mee Young Ahn 1; Hee Jin Kim 1; In Young Kim 2; Soon Young Han 2; Tae Seok Kang 2; Jin Hwan Hong 2; Kui Lea Park 2; Byung Mu Lee 3; Hyung Sik Kim 1; Email Address: hkim@pusan.ac.kr; Affiliations: 1: Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, San 30, Jangjun-dong, Gumjung-ku, Busan 609-735, South Korea; 2: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, South Korea; 3: Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun-Dong 300, Changan-Ku, Kyunggi-Do, Suwon 440-746, South Korea; Issue Info: Jun2007, Vol. 22 Issue 3, p245; Thesaurus Term: DISEASES; Thesaurus Term: Biotransformation (Metabolism); Subject Term: Hyperthyroidism; Subject Term: Thyroid diseases; Subject Term: Rats; Subject Term: Thyroid hormones; Subject Term: Malondialdehyde; Subject Term: Catalase; Subject Term: Superoxide dismutase; Subject Term: Peroxisomes; Subject Term: Male reproductive organs; Author-Supplied Keyword: 8-hydroxy-2-deoxyguanosine; Author-Supplied Keyword: catalase; Author-Supplied Keyword: di(n-butyl) phthalate; Author-Supplied Keyword: glutathione peroxidase; Author-Supplied Keyword: malondialdehyde; Author-Supplied Keyword: peroxisome proliferator-activated receptor; Author-Supplied Keyword: superoxide dismutase; Author-Supplied Keyword: thyroid hormone; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 2 Black and White Photographs, 14 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ilev, I. K.
T1 - A simple confocal fibre-optic laser method for intraocular lens power measurement.
JO - Eye
JF - Eye
Y1 - 2007/06//
VL - 21
IS - 6
M3 - Article
SP - 819
EP - 823
PB - Nature Publishing Group
SN - 0950222X
AB - PurposeTo develop novel confocal fibre-optic laser method (CFOLM) for accurate and objective measuring of the dioptric power of both positive and negative intraocular lenses (IOLs).MethodsThe CFOLM principle of operation is based on a simple apertureless single-mode fibre laser confocal design. The key element is a single-mode fibre coupler that serves simultaneously as a point light source (3–5 μm fibre diameter) used for the formation of a collimated Gaussian beam, and as a confocal point receiver that is highly sensitive to spatial displacements of the focused backreflectance laser emission. The basic CFOLM systems include IOL testing set-ups for the measurement of both positive and negative IOLs.ResultsThe CFOLM designs provide high accuracy (≤1 μm) in spatially locating the IOL focal point and in measuring the focal length in a broad range of both positive and negative powers including high-magnification IOLs with power greater than ±20 D. We have tested various IOL samples with both positive (+5 to +30 D) and negative (−5 to −20 D) powers and we have obtained high levels of power testing repeatability estimated by a SD in the interval of 0.004–0.06/0.003–0.013 D and a relative error in the interval of 0.015–0.3/0.02–0.16%, for positive/negative IOLs, respectively.ConclusionsThe presented IOL power testing method offers a simple, accurate, objective, quick, and relatively inexpensive approach for dioptric power measurement of positive and negative IOLs. It provides an independent source of IOL power measurement data and information for evaluating the effectiveness and safety of novel IOL products.Eye (2007) 21, 819–823; doi:10.1038/sj.eye.6702406; published online 28 July 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Eye is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAOCULAR lenses
KW - OPHTHALMIC lenses
KW - SINGLE-mode optical fibers
KW - GAUSSIAN beams
KW - CATARACT surgery
KW - confocal fibre-optic laser method
KW - intraocular lens dioptric power
KW - single-mode fibre coupler
N1 - Accession Number: 25299090; Ilev, I. K. 1; Email Address: ilko.ilev@fda.hhs.gov; Affiliation: 1: Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA; Source Info: Jun2007, Vol. 21 Issue 6, p819; Subject Term: INTRAOCULAR lenses; Subject Term: OPHTHALMIC lenses; Subject Term: SINGLE-mode optical fibers; Subject Term: GAUSSIAN beams; Subject Term: CATARACT surgery; Author-Supplied Keyword: confocal fibre-optic laser method; Author-Supplied Keyword: intraocular lens dioptric power; Author-Supplied Keyword: single-mode fibre coupler; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/sj.eye.6702406
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Basu, Jayasree
AU - Mobley, Lee R.
T1 - Illness severity and propensity to travel along the urban–rural continuum
JO - Health & Place
JF - Health & Place
Y1 - 2007/06//
VL - 13
IS - 2
M3 - Article
SP - 381
EP - 399
SN - 13538292
AB - Abstract: In this paper, we examine whether the relationship between severity of illness and the propensity to travel greater distance relative to the norm (defined by peers in one''s county of residence) is uniform across the urban–rural continuum of geography or over time. We focus on the elderly in New York State who have been admitted to hospital for ambulatory care sensitive conditions (ACSCs), admissions which are presumed to be representative of usual travel patterns. The two periods of time examined span the implementation of the Balanced Budget Act (BBA) of 1997, which established the Medicare Rural Hospital Flexibility Program, a major national initiative to strengthen rural health care with the development of rural Critical Access Hospitals (CAHs). As the number of NY rural hospitals certified as CAH increased with the expanded funding from the BBA, one might expect to see increased distance traveled by more severely ill rural elderly, as their CAHs referred them to their affiliated support hospitals. The logistic regression estimates support this expectation, highlighting an asymmetrical relationship between relative distance and severity across patients in rural and urban areas. Despite a general decline in average propensity to travel further than the norm across the landscape, severity had a larger impact on travel propensity in rural areas, which increased over time. [Copyright &y& Elsevier]
AB - Copyright of Health & Place is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTPATIENT medical care
KW - RURAL health services
KW - OLDER people
KW - NEW York (State)
KW - Critical access hospital
KW - Distance
KW - Elderly managed care
KW - Severity of illness
KW - Travel patterns
KW - Urban and rural
N1 - Accession Number: 23809668; Basu, Jayasree 1; Email Address: Jbasu@ahrq.gov Mobley, Lee R. 2; Affiliation: 1: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA 2: Research Triangle Institute, North Carolina, USA; Source Info: Jun2007, Vol. 13 Issue 2, p381; Subject Term: OUTPATIENT medical care; Subject Term: RURAL health services; Subject Term: OLDER people; Subject Term: NEW York (State); Author-Supplied Keyword: Critical access hospital; Author-Supplied Keyword: Distance; Author-Supplied Keyword: Elderly managed care; Author-Supplied Keyword: Severity of illness; Author-Supplied Keyword: Travel patterns; Author-Supplied Keyword: Urban and rural; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.healthplace.2006.03.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106021588
T1 - Illness severity and propensity to travel along the urban-rural continuum.
AU - Basu J
AU - Mobley LR
Y1 - 2007/06//
N1 - Accession Number: 106021588. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Health Services Administration; Peer Reviewed; Public Health. Special Interest: Gerontologic Care; Public Health. NLM UID: 9510067.
KW - Ambulatory Care Facilities -- Utilization -- In Old Age
KW - Rural Health Services -- Utilization -- In Old Age
KW - Travel
KW - Urban Health Services -- Utilization -- In Old Age
KW - Aged
KW - Aged, 80 and Over
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Health Services Research
KW - Multiple Logistic Regression
KW - New York
KW - Odds Ratio
KW - P-Value
KW - Severity of Illness Indices
KW - Human
SP - 381
EP - 399
JO - Health & Place
JF - Health & Place
JA - HEALTH PLACE
VL - 13
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - In this paper, we examine whether the relationship between severity of illness and the propensity to travel greater distance relative to the norm (defined by peers in one's county of residence) is uniform across the urban-rural continuum of geography or over time. We focus on the elderly in New York State who have been admitted to hospital for ambulatory care sensitive conditions (ACSCs), admissions which are presumed to be representative of usual travel patterns. The two periods of time examined span the implementation of the Balanced Budget Act (BBA) of 1997, which established the Medicare Rural Hospital Flexibility Program, a major national initiative to strengthen rural health care with the development of rural Critical Access Hospitals (CAHs). As the number of NY rural hospitals certified as CAH increased with the expanded funding from the BBA, one might expect to see increased distance traveled by more severely ill rural elderly, as their CAHs referred them to their affiliated support hospitals. The logistic regression estimates support this expectation, highlighting an asymmetrical relationship between relative distance and severity across patients in rural and urban areas. Despite a general decline in average propensity to travel further than the norm across the landscape, severity had a larger impact on travel propensity in rural areas, which increased over time.
SN - 1353-8292
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. Jbasu@ahrq.gov
U2 - PMID: 16697689.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hongwei Hsiao
AU - Jennifer Whitestone
AU - Tsui-Ying Kau
T1 - Evaluation of Fall Arrest Harness Sizing Schemes.
JO - Human Factors
JF - Human Factors
Y1 - 2007/06//
VL - 49
IS - 3
M3 - Article
SP - 447
EP - 464
SN - 00187208
AB - Objective: This paper evaluated harness sizing schemes and anthropometric criteria for harness design applications. Background: Updated harness sizing systems are needed to accommodate diverse populations in the current workforce. Method: Three-dimensional torso scan data and human-harness interfaces from 108 women and 108 men were digitally captured. Abounding box approach was employed to quantify the effect of torso shape and size on fall harness fit. Results: A logistic regression model with eight equations was developed and tested to classify more than 96% of participants to the best-fitting size. Conclusion: Study outcomes suggested an alternative system of two sizes for women and three sizes for men over the current four-size unisex system. In addition, thigh strap angle and back D ring location could be utilized along with current harness static fit test criteria to further enhance postfall harness fit predictions. Application: This research could help reduce the risk of worker injury resulting from poor fit, improper size selection, or failure to don the harness properly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVALUATION
KW - HARNESSES (Sporting goods)
KW - SIZE
KW - INDUSTRIAL safety
KW - REGRESSION analysis
N1 - Accession Number: 25162096; Hongwei Hsiao 1; Email Address: hhsiao@cdc.gov Jennifer Whitestone 2 Tsui-Ying Kau 3; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Total Contact, Inc., Germantown, Ohio 3: University of Michigan, Ann Arbor, Michigan; Source Info: Jun2007, Vol. 49 Issue 3, p447; Subject Term: EVALUATION; Subject Term: HARNESSES (Sporting goods); Subject Term: SIZE; Subject Term: INDUSTRIAL safety; Subject Term: REGRESSION analysis; Number of Pages: 18p; Document Type: Article
L3 - 10.1518/001872007X200094
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hellinger, Fred J.
T1 - The Changing Pattern of Hospital Care for Persons Living With HIV.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2007/06//6/1/2007
VL - 45
IS - 2
M3 - Article
SP - 239
EP - 246
SN - 15254135
AB - The article compares inpatient utilization and costs by persons living with HIV in 2000 with inpatient utilization and costs in 2004 in the United States. It shows that the average age of a hospitalized patient with HIV rose from 41 to 44 years. The article reveals that hospitalized patients living with HIV are getting older and sicker, although the average number of admissions per person living with HIV continues to decline.
KW - HOSPITAL care
KW - HIV-positive persons
KW - HIV infections
KW - HOSPITAL patients
KW - UNITED States
KW - cost
KW - hospital care
KW - length of stay
N1 - Accession Number: 25959553; Hellinger, Fred J. 1; Email Address: fhelling@ahrq.gov; Affiliation: 1: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD; Source Info: 6/1/2007, Vol. 45 Issue 2, p239; Subject Term: HOSPITAL care; Subject Term: HIV-positive persons; Subject Term: HIV infections; Subject Term: HOSPITAL patients; Subject Term: UNITED States; Author-Supplied Keyword: cost; Author-Supplied Keyword: hospital care; Author-Supplied Keyword: length of stay; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105930262
T1 - The validity of ICD-9-CM codes in identifying postoperative deep vein thrombosis and pulmonary embolism.
AU - Zhan C
AU - Battles J
AU - Chiang Y
AU - Hunt D
Y1 - 2007/06//2007 Jun
N1 - Accession Number: 105930262. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; algorithm; research; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care; Quality Assurance. NLM UID: 101238023.
KW - International Classification of Diseases
KW - Postoperative Complications
KW - Pulmonary Embolism
KW - Venous Thrombosis
KW - Billing and Claims
KW - Coding
KW - Inpatients
KW - Medical Records
KW - Medicare
KW - Patient Safety
KW - Predictive Validity
KW - Random Sample
KW - Record Review
KW - Retrospective Design
KW - Sensitivity and Specificity
KW - Validation Studies
KW - Human
SP - 326
EP - 331
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 33
IS - 6
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - Background: Deep vein thrombosis and pulmonary embolism (DVT/PE) are common complications after surgery and are associated with substantial excess mortality and length of stay. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes recorded in hospital claims have been used to identify and study DVT/PE, but the validity of this method is not well studied.Methods: Identification of postoperative DVT/PE events were compared using ICD-9-CM codes and medical record abstraction in random samples of hospital discharges of Medicare beneficiaries in 2002-2004.Results: Among 20,868 eligible surgical hospitalizations, 232 DVT cases and 95 PE cases were identified by ICD-9-CM codes; 108 DVT cases and 31 PE cases by medical record abstraction; 72 DVT cases and 23 PE cases by both methods. The resulting estimates of PPV of ICD-9-CM coding were 31% (72/232 cases) for DVT, 24% (23/95) for PE, and 29% (90/308) for DVT/PE combined. The resulting sensitivity estimates were 67% (72/108 cases) for DVT, 74% (23/31) for PE, and 68% (90/133) for DVT/PE combined.Discussion: ICD-9-CM codes in Medicare claims are sensitive but have limited predictive validity in identifying postoperative DVT/PE. Improvements in the validity are needed before the indicator can be used for safety performance assessment.
SN - 1553-7250
AD - Staff Service Fellow, Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services, Rockville, Maryland; Chunliu.Zhan@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Edwards, Mark C.
AU - Gardner, Eunice S.
AU - Chelonis, John J.
AU - Schulz, Eldon G.
AU - Flake, Rebecca A.
AU - Diaz, Pamela F.
T1 - Estimates of the Validity and Utility of the Conners’ Continuous Performance Test in the Assessment of Inattentive and/or Hyperactive-Impulsive Behaviors in Children.
JO - Journal of Abnormal Child Psychology
JF - Journal of Abnormal Child Psychology
Y1 - 2007/06//
VL - 35
IS - 3
M3 - Article
SP - 393
EP - 404
SN - 00910627
AB - This study evaluated the validity and classification utility of the Conners’ Continuous Performance Test (CCPT) in the assessment of inattentive and hyperactive-impulsive behaviors in children. Significant, positive correlations between the CCPT parameters and behavioral ratings of ADHD behaviors were hypothesized. In addition, it was hypothesized that the CCPT parameters would perform better than a random test (chance) and show fair to moderate utility of classification across the different indices. Participants were 104 children between 6 and 12 years of age who were referred for evaluation of attention problems. The first hypothesis was not supported. There were no significant, positive correlations between the CCPT parameters and parent and teacher ratings of inattentive and hyperactive-impulsive behaviors. The second hypothesis was only partially supported. The CCPT Overall Index and the Omission Errors (84th percentile cutoff) performed better than a random test; however, the utility of the CCPT Overall Index only ranged from poor to slight. Receiver operating characteristic analyses showed the accuracy of the CCPT to be low. The implications and limitations of this study and future research directions are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Abnormal Child Psychology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONNERS' Continuous Performance Test
KW - ATTENTION-deficit hyperactivity disorder
KW - BEHAVIOR disorders in children
KW - NEUROPSYCHOLOGICAL tests for children
KW - PEDIATRIC neuropsychology
KW - CLINICAL neuropsychology
KW - NEUROLOGIC examination
KW - PSYCHOLOGICAL tests
KW - ADHD
KW - Assessment
KW - Children
KW - Conner’s continuous performance task
KW - Conner's continuous performance task
KW - CPT
N1 - Accession Number: 25138074; Edwards, Mark C. 1,2; Email Address: edwardsmark@uams.edu Gardner, Eunice S. 1,3,4 Chelonis, John J. 1,3,5 Schulz, Eldon G. 1 Flake, Rebecca A. 3,6 Diaz, Pamela F. 3; Affiliation: 1: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202-3591, USA 2: Pediatric Psychology, Arkansas Children's Hospital, 800 Marshall Street, Slot 512-21, Little Rock, AR 72202-3591 3: Department of Research and Sponsored Programs, University of Arkansas at Little Rock, USA 4: Department of Psychology, Idaho State University at Pocatello, USA 5: National Center for Toxicological Research, Jefferson, Arkansas, USA 6: Department of Psychology, University of Kentucky at Lexington, USA; Source Info: Jun2007, Vol. 35 Issue 3, p393; Subject Term: CONNERS' Continuous Performance Test; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: BEHAVIOR disorders in children; Subject Term: NEUROPSYCHOLOGICAL tests for children; Subject Term: PEDIATRIC neuropsychology; Subject Term: CLINICAL neuropsychology; Subject Term: NEUROLOGIC examination; Subject Term: PSYCHOLOGICAL tests; Author-Supplied Keyword: ADHD; Author-Supplied Keyword: Assessment; Author-Supplied Keyword: Children; Author-Supplied Keyword: Conner’s continuous performance task; Author-Supplied Keyword: Conner's continuous performance task; Author-Supplied Keyword: CPT; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1007/s10802-007-9098-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106153219
T1 - Challenges in replicating interventions.
AU - Bell SG
AU - Newcomer SF
AU - Bachrach C
AU - Borawski E
AU - Jemmott JB III
AU - Morrison D
AU - Stanton B
AU - Tortolero S
AU - Zimmerman R
Y1 - 2007/06//
N1 - Accession Number: 106153219. Language: English. Entry Date: 20070914. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Pediatric Care; Public Health. NLM UID: 9102136.
KW - HIV Infections -- Prevention and Control
KW - Program Development -- Methods
KW - Replication Studies
KW - Communities
KW - Cultural Sensitivity
KW - Culture
KW - National Institutes of Health (U.S.)
SP - 514
EP - 520
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
JA - J ADOLESC HEALTH
VL - 40
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. METHODS: Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. RESULTS: Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention 'to scale' are not discussed. CONCLUSIONS: Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations.
SN - 1054-139X
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 17531757.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Achutan, Chandram
AU - Tubbs, Randy L.
T1 - A Task-Based Assessment of Noise Levels at a Swine Confinement.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/06//
VL - 12
IS - 2
M3 - Article
SP - 55
EP - 65
SN - 1059924X
AB - This study describes a task-based noise evaluation conducted at a community college that operated a small swine confinement for training and profit. Seven full-shift dosimeter samples and area noise data were collected during the evaluation. The time weighted average noise levels were all well below the Occupational Safety and Health Administration's (OSHA) Permissible Exposure Limit, but exceeded the National Institute for Occupational Safety and Health's Recommended Exposure Limit on three of seven occasions. The potential for high noise exposures is evidenced in the noise dose measured for specific activities such as power washing, ear clipping, and snout snaring. When the data were extrapolated to depict exposures where specific tasks were carried out over a full shift, tasks such as power washing and snout snaring would exceed the OSHA Action Level (AL). Employees who exceed the OSHA AL are required to be enrolled in a hearing conservation program. doi:10.1300/J096v12n02_07 [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SWINE
KW - NOISE
KW - INDUSTRIAL hygiene
KW - UNITED States
KW - dosimetry
KW - noise
KW - spectral analysis
KW - Swine confinement
KW - task analysis
KW - teaching facility
KW - NATIONAL Institute for Occupational Safety & Health
KW - UNITED States. Occupational Safety & Health Administration
N1 - Accession Number: 28032549; Achutan, Chandram 1; Email Address: cma4@cdc.gov Tubbs, Randy L. 2; Affiliation: 1: Industrial hygienist, Hazard Evaluations and Technical Assistance Branch, National Institute for Occupational Safety and Health 2: Psychoacoustician, Hazard Evaluations and Technical Assistance Branch, National Institute for Occupational Safety and Health; Source Info: 2007, Vol. 12 Issue 2, p55; Subject Term: SWINE; Subject Term: NOISE; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; Author-Supplied Keyword: dosimetry; Author-Supplied Keyword: noise; Author-Supplied Keyword: spectral analysis; Author-Supplied Keyword: Swine confinement; Author-Supplied Keyword: task analysis; Author-Supplied Keyword: teaching facility; Company/Entity: NATIONAL Institute for Occupational Safety & Health Company/Entity: UNITED States. Occupational Safety & Health Administration; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 11p; Illustrations: 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1300/J096v12n02_07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hariharan, Prasanna
AU - Chang, Isaac
AU - Myers, Matthew R.
AU - Banerjee, Rupak K.
T1 - Radio-Frequency Ablation in a Realistic Reconstructed Hepatic Tissue.
JO - Journal of Biomechanical Engineering
JF - Journal of Biomechanical Engineering
Y1 - 2007/06//
VL - 129
IS - 3
M3 - Article
SP - 354
EP - 364
SN - 01480731
AB - This study uses a reconstructed vascular geometry to evaluate the thermal response of tissue during a three-dimensional radiofrequency (rf) tumor ablation. MRI images of a sectioned liver tissue containing arterial vessels are processed and converted into a finite-element mesh. A rf heat source in the form of a spherically symmetric Gaussian distribution, fit from a previously computed profile, is employed. Convective cooling within large blood vessels is treated using direct physical modeling of the heat and momentum transfer within the vessel. Calculations of temperature rise and thermal dose are performed for transient rf procedures in cases where the tumor is located at three different locations near the bifurcation point of a reconstructed artery. Results demonstrate a significant dependence of tissue temperature profile on the reconstructed vasculature and the tumor location. Heat convection through the arteries reduced the steady-state temperature rise, relative to the no-flow case, by up to 70% in the targeted volume. Blood flow also reduced the thermal dose value, which quantifies the extent of cell damage, from ∼3600 min, for the no-flow condition, to 10 min for basal flow (13.8 cm/s). Reduction of thermal dose below the threshold value of 240 min indicates ablation procedures that may inadequately elevate the temperature in some regions, thereby permitting possible tumor recursion. These variations are caused by vasculature tortuosity that are patient specific and can be captured only by the reconstruction of the realistic geometry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biomechanical Engineering is the property of American Society of Mechanical Engineers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIO frequency
KW - LIVER
KW - TISSUES
KW - BLOOD flow
KW - HEMODYNAMICS
KW - BILIARY tract
KW - IMAGING systems in medicine
N1 - Accession Number: 25395798; Hariharan, Prasanna 1 Chang, Isaac 2 Myers, Matthew R. 3 Banerjee, Rupak K. 4; Affiliation: 1: Graduate Student Mechanical Engineering Department, University of Cincinnati, 688 Rhodes Hall, P.O. Box 210072, Cincinnati, OH 45221-0072 2: Biomedical Engineer Division of Physics, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002 3: Research Physicist Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002 4: Associate Professor Mechanical Engineering Department, 688 Rhodes Hall, University of Cincinnati, PO Box 210072 Cincinnati, OH 45221-0072; Source Info: Jun2007, Vol. 129 Issue 3, p354; Subject Term: RADIO frequency; Subject Term: LIVER; Subject Term: TISSUES; Subject Term: BLOOD flow; Subject Term: HEMODYNAMICS; Subject Term: BILIARY tract; Subject Term: IMAGING systems in medicine; Number of Pages: 11p; Document Type: Article
L3 - 10.1115/1.2720912
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen-An Tsai
AU - Dung-Tsa Chen
AU - Chen, James J.
AU - Balch, Charles M.
AU - Thompson, John F.
AU - Seng-Jaw Soong
T1 - An Integrated Tree-Based Classification Approach to Prognostic Grouping with Application to Localized Melanoma Patients.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/06//
VL - 17
IS - 3
M3 - Article
SP - 445
EP - 460
PB - Taylor & Francis Ltd
SN - 10543406
AB - We propose an integrated tree-based approach for prognostic grouping of localized melanoma patients. This approach incorporates the survival tree model with the agglomerative hierarchical clustering to group terminal subgroups with similar prognoses together. The Brier score is used to evaluate the goodness of fit and the k-fold cross-validation test is used to evaluate the reproducibility of the scheme for prediction. The proposed approach is applied to an American Joint Committee on Cancer (AJCC) localized melanoma data set and compared with the current AJCC staging system. This approach performs more efficiently than the standard tree methods and has made improvement over the current AJCC melanoma staging system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANOMA
KW - AGGLOMERATION (Materials)
KW - CANCER research
KW - CANCER patients
KW - DIAGNOSIS
KW - Cross-validation
KW - Disease staging system
KW - Integrated tree-based classification
KW - Modified log-rank test
N1 - Accession Number: 24953271; Chen-An Tsai 1 Dung-Tsa Chen 2 Chen, James J. 3 Balch, Charles M. 4 Thompson, John F. 5 Seng-Jaw Soong 6; Email Address: sjsoong@uab.edu; Affiliation: 1: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan 2: Biostatistics Division, Moffit Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA 4: Department of Surgery, John Hopkins Medical Institutions, Baltimore, Maryland, USA 5: Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia 6: Biostatistics and Bioinformatics Unit, University of Alabama at Birmingham, Birmingham, Alabama, USA; Source Info: Jun2007, Vol. 17 Issue 3, p445; Subject Term: MELANOMA; Subject Term: AGGLOMERATION (Materials); Subject Term: CANCER research; Subject Term: CANCER patients; Subject Term: DIAGNOSIS; Author-Supplied Keyword: Cross-validation; Author-Supplied Keyword: Disease staging system; Author-Supplied Keyword: Integrated tree-based classification; Author-Supplied Keyword: Modified log-rank test; NAICS/Industry Codes: 212210 Iron Ore Mining; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 16p; Illustrations: 3 Diagrams, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10543400701199585
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zaslavsky, Boris G.
T1 - Calculation of Tolerance Limits and Sample Size Determination for Clinical Trials with Dichotomous Outcomes.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/06//
VL - 17
IS - 3
M3 - Article
SP - 481
EP - 491
PB - Taylor & Francis Ltd
SN - 10543406
AB - This research provides an algorithm for calculating uniformly most accurate tolerance intervals in clinical trials with dichotomous outcomes. The link between confidence intervals for proportions and tolerance intervals for numbers of outcomes is established. Tolerance intervals and sample size estimates for clinical trials may be calculated using StatXact. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALGORITHMS
KW - CLINICAL trials
KW - MEDICAL research
KW - CLINICAL medicine
KW - DRUG tolerance
KW - Binomial distribution
KW - Clinical trial
KW - Confidence probability
KW - Dichotomous outcome
KW - Negative-binomial distribution
KW - Tolerance limit
N1 - Accession Number: 24953269; Zaslavsky, Boris G. 1; Email Address: Boris.Zaslavsky@FDA.HHS.gov; Affiliation: 1: Food and Drug Administration, Rockville Pike, Maryland, USA; Source Info: Jun2007, Vol. 17 Issue 3, p481; Subject Term: ALGORITHMS; Subject Term: CLINICAL trials; Subject Term: MEDICAL research; Subject Term: CLINICAL medicine; Subject Term: DRUG tolerance; Author-Supplied Keyword: Binomial distribution; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Confidence probability; Author-Supplied Keyword: Dichotomous outcome; Author-Supplied Keyword: Negative-binomial distribution; Author-Supplied Keyword: Tolerance limit; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Document Type: Article
L3 - 10.1080/10543400701199601
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen Brinker
AU - Andrew Mosholder
AU - Stephanie D. Schech
AU - Margaret Burgess
AU - Mark Avigan
T1 - Indication and Use of Drug Products Used to Treat Attention-DeficitHyperactivity Disorder A Cross-Sectional Study with Inference on the Likelihood of Treatment in Adulthood.
JO - Journal of Child & Adolescent Psychopharmacology
JF - Journal of Child & Adolescent Psychopharmacology
Y1 - 2007/06//
VL - 17
IS - 3
M3 - Article
SP - 328
EP - 333
SN - 10445463
AB - IntroductionPublished literature suggests that attention-deficithyperactivity disorder (ADHD) affects 4 of adults and that as many as 60 of children with a diagnosis of ADHD will continue to have problems with inattention and impulsivity in adulthood. We analyzed cross-sectional prescription claims data and data from a national survey of office-based physicians for further inference on the likelihood of treatment with ADHD medications into adulthood.MethodsThis study used data from a proprietary, national survey of office-based physicians (the IMS Health National Disease and Therapeutic Index, NDTITM) to describe the indication associated with office visits with mention of common stimulant medications and atomoxetine. Enrollment and prescription claims data maintained by a large national health-care company were analyzed for age-specific utilization of these same agents.ResultsData from the NDTITMsuggest that the vast majority of visits associated with a stimulant medication or atomoxetine was coded with a diagnosis consistent with a mental health condition and not obesityweight loss. The health plans included in this study processed 222,096 prescriptions for stimulant medications and atomoxetine among 43,175 unique patients aged 1–64 years during the calendar year 2004. Analyses of pharmacy claims data showed a steep increase in use through age 11 (prevalence 70.3 per 1,000 covered lives) followed by a marked decrease and plateau from age 25 through age 64 years (prevalence 5 to 10 per 1,000 covered lives).ConclusionsOn the basis of comparison of the prevalence rate peak of 70 per 1,000 around age 11 years to a plateau of 7 per 1,000 during the early career years, our results are consistent with a prediction that at least one child in 10 placed on an ADHD medication in childhood will receive treatment in to adulthood. The decrease in the prevalence of use of these medications with advancing age as seen in this cross-sectional study may reflect upon several clinical and secular factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Child & Adolescent Psychopharmacology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - ATTENTION-deficit hyperactivity disorder
KW - BEHAVIOR disorders in children
KW - PATHOLOGICAL psychology
N1 - Accession Number: 25856741; Allen Brinker 1 Andrew Mosholder 1 Stephanie D. Schech 2 Margaret Burgess 2 Mark Avigan 1; Affiliation: 1: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. 2: Center for Health Care Policy and Evaluation, Eden Prairie, Minnesota.; Source Info: Jun2007, Vol. 17 Issue 3, p328; Subject Term: HEALTH; Subject Term: ATTENTION-deficit hyperactivity disorder; Subject Term: BEHAVIOR disorders in children; Subject Term: PATHOLOGICAL psychology; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weisz, Adrian
AU - Idina, Ana
AU - Ben-Ari, Julius
AU - Karni, Miriam
AU - Mandelbaum, Asher
AU - Ito, Yoichiro
T1 - Preparative separation of isomeric and stereoisomeric dicarboxylic acids by pH-zone-refining counter-current chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2007/06//
VL - 1151
IS - 1/2
M3 - Article
SP - 82
EP - 90
SN - 00219673
AB - Abstract: This work involves the preparative separation of some isomeric dicarboxylic acids using pH-zone-refining counter-current chromatography (CCC), a relatively new preparative technique for the separation of ionizable compounds. The paper concentrates especially on the separation of a synthetic mixture of closely related cis and trans pairs of 1-methyl- and 1,3-dimethyl-1,3-cyclohexanedicarboxylic acids. The elution sequence of the isomers is discussed in terms of their relative acidities (pK a values) in solution and gas phase, hydrophobicities, and steric configuration. Two possible explanations are suggested for the mechanism of separation. They both involve the amount of retainer acid used, as it affects the separation and plays a role in the chemohydrodynamic equilibrium of the dicarboxylic acids in the column. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hydrogen-ion concentration
KW - Stereoisomers
KW - Carboxylic acids
KW - Countercurrent chromatography
KW - Dicarboxylic acids
KW - Dimerization energies
KW - Mechanism
KW - pH-zone-refining counter-current chromatography
KW - pK a
KW - Separation of stereoisomers
N1 - Accession Number: 24970436; Weisz, Adrian 1; Email Address: adrian.weisz@fda.hhs.gov; Idina, Ana 2; Ben-Ari, Julius 2; Karni, Miriam 2,3; Mandelbaum, Asher 2; Ito, Yoichiro 4; Affiliations: 1: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; 2: Department of Chemistry, Technion-Israel Institute of Technology, 32000 Haifa, Israel; 3: Lise Meitner-Minerva Center for Computational Quantum Chemistry, Technion-Israel Institute of Technology, 32000 Haifa, Israel; 4: Center for Biochemistry and Biophysics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Issue Info: Jun2007, Vol. 1151 Issue 1/2, p82; Thesaurus Term: Hydrogen-ion concentration; Subject Term: Stereoisomers; Subject Term: Carboxylic acids; Subject Term: Countercurrent chromatography; Author-Supplied Keyword: Dicarboxylic acids; Author-Supplied Keyword: Dimerization energies; Author-Supplied Keyword: Mechanism; Author-Supplied Keyword: pH-zone-refining counter-current chromatography; Author-Supplied Keyword: pK a; Author-Supplied Keyword: Separation of stereoisomers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2007.03.085
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DB - eih
ER -
TY - JOUR
AU - Miller, Ron A.
AU - Reimschuessel, Renate
AU - Carson, Mary C.
T1 - Determination of oxytetracycline levels in rainbow trout serum on a biphenyl column using high-performance liquid chromatography
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2007/06//
VL - 852
IS - 1/2
M3 - Article
SP - 655
EP - 658
SN - 15700232
AB - Abstract: We developed a simple and sensitive high-performance liquid chromatography method on a biphenyl column to determine oxytetracycline (OTC) levels in rainbow trout serum. The assay used deproteination, filtration, and subsequent separation on a reverse-phase biphenyl column, with UV detection at 355nm. OTC (7.8–7.9min) was completely resolved from structurally similar riboflavin (10.4–10.5min), a common feed supplement. Estimated limits of detection and quantitation of OTC were 0.01 and 0.04μg/mL, respectively. The average recovery for OTC was 102% with a R.S.D. of 8.34%. Calibration standards were linear from 0.01 to 10μg/mL. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIPHENYL compounds
KW - OXYTETRACYCLINE
KW - RAINBOW trout
KW - VITAMIN B2
KW - HIGH performance liquid chromatography
KW - Aquaculture
KW - Fish
KW - High-performance liquid chromatography
KW - HPLC
KW - Oxytetracycline
KW - Rainbow trout
KW - Riboflavin
N1 - Accession Number: 25343892; Miller, Ron A.; Email Address: Ron.Miller@fda.hhs.gov Reimschuessel, Renate 1 Carson, Mary C. 1; Affiliation: 1: US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jun2007, Vol. 852 Issue 1/2, p655; Subject Term: BIPHENYL compounds; Subject Term: OXYTETRACYCLINE; Subject Term: RAINBOW trout; Subject Term: VITAMIN B2; Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: Aquaculture; Author-Supplied Keyword: Fish; Author-Supplied Keyword: High-performance liquid chromatography; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Oxytetracycline; Author-Supplied Keyword: Rainbow trout; Author-Supplied Keyword: Riboflavin; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jchromb.2007.01.040
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ichikawa, Norimitsu
T1 - Electrostatically induced potential difference between conductive objects contained in a partially opened metal box
JO - Journal of Electrostatics
JF - Journal of Electrostatics
Y1 - 2007/06//
VL - 65
IS - 7
M3 - Article
SP - 414
EP - 422
SN - 03043886
AB - Abstract: When a charged body exists near an opening of a partially opened metal box of an electronic apparatus, a potential difference is induced between conductive objects contained in the box. If the charged body moves, the potential difference changes and is capable of causing the breakdown of microelectronic devices in the box. However, one can rarely find a thorough study of this voltage. In this study, a potential difference induced between two metal foils in the partially opened metal box is measured without electrical connections. In some experiments, a piece of foil is grounded, whereas in others, both foils are ungrounded (floating). The measured result shows that the potential difference for a piece of foil grounded in the box is approximately 80% larger than that for both foils ungrounded. The potential difference decreases linearly by increasing the logarithm of the distance between the charged body and the front of the metal box. The result will provide a basis for a design to prevent the possible malfunction and breakdown of electronic apparatuses. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electrostatics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCIENTIFIC apparatus & instruments
KW - METAL foils
KW - ELECTRONICS
KW - LOGARITHMS
KW - Charged body
KW - Electrostatically induced potential difference
KW - Measurement without electrical connections
KW - Partially opened metal box
N1 - Accession Number: 24387420; Ichikawa, Norimitsu 1; Email Address: ichikawa@s.jniosh.go.jp; Affiliation: 1: National Institute of Occupational Safety and Health, Tokyo University of Agriculture and Technology, 1-4-6, Umezono, Kiyose, Tokyo 204-0024, Japan; Source Info: Jun2007, Vol. 65 Issue 7, p414; Subject Term: SCIENTIFIC apparatus & instruments; Subject Term: METAL foils; Subject Term: ELECTRONICS; Subject Term: LOGARITHMS; Author-Supplied Keyword: Charged body; Author-Supplied Keyword: Electrostatically induced potential difference; Author-Supplied Keyword: Measurement without electrical connections; Author-Supplied Keyword: Partially opened metal box; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 332999 All Other Miscellaneous Fabricated Metal Product Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.elstat.2006.10.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jonathan Coleman
AU - Amar Singh
AU - Peter Pinto
AU - John Phillips
AU - William Pritchard
AU - Diane Wray-Cahen
AU - Bradford J. Wood
T1 - Radiofrequency-Assisted Laparoscopic Partial Nephrectomy Clinical and Histologic Results.
JO - Journal of Endourology
JF - Journal of Endourology
Y1 - 2007/06//
VL - 21
IS - 6
M3 - Article
SP - 600
EP - 605
SN - 08927790
AB - Purpose To evaluate a surface conductive radiofrequency (RF) coagulation instrument (Tissuelink FB3.0) in laparoscopic and open partial nephrectomy (PN) in hereditary kidney cancer. The lesion depth and viability in the pathologic specimens from a surgical series and an acute porcine model were characterized under conditions of vascular perfusion and occlusion.Materials and Methods A total of 19 patients underwent 20 laparoscopic and open procedures with the device. Data were acquired on tumor number, size, operative time, blood loss, length of stay, renal function, complications, pathologic diagnosis, and surgical-margin status. Renal lesions were created in pigs with the device, ultrasonic shears, and a standard electrocautery for specified time intervals and operative energy settings. These lesions were analyzed for depth, diameter, and tissue viability.Results In 20 separate (14 laparoscopic; 6 open) procedures in 19 patients, a total of 112 tumors were removed (range 1–31 tumors per procedure). The median operative time, blood loss, and length of stay were 310 minutes, 250 mL, and 4 days, respectively. There were no positive surgical margins. Median preoperative and postoperative creatinine concentrations were similar (1.0 v1.0 mgdL). The average treatment margin depth was 3 mm. In the porcine experiments, the treatment depth in the unclamped vascular model was significantly less in than the clamped model (4.0 ± 1.7 mm v7.0 ± 1.6 mm; P< 0.05). Lesion depth and diameter increased with treatment time. Viability depth correlated well with the depth of the visible thermal lesions (Pearson correlation 0.989).Conclusions This RF energy device can provided adequate and uniform hemostatic control without hilar clamping during laparoscopic and open PN for hereditary renal tumors. Gross measures of renal function after surgery appeared clinically unchanged. Coagulation depth is dependent on both tissue perfusion and time in the porcine model. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Endourology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LAPAROSCOPY
KW - ABDOMEN -- Examination
KW - NUCLEAR spectroscopy
KW - RADIO frequency
N1 - Accession Number: 25856937; Jonathan Coleman 1 Amar Singh 1 Peter Pinto 1 John Phillips 1 William Pritchard 2 Diane Wray-Cahen 2 Bradford J. Wood 3; Affiliation: 1: Urologic Oncology Branch, National Institutes of Health, Bethesda, Maryland. 2: US Food and Drug Administration, Rockville, Maryland. 3: Diagnostic Radiology Department, National Institutes of Health, Bethesda, Maryland.; Source Info: Jun2007, Vol. 21 Issue 6, p600; Subject Term: LAPAROSCOPY; Subject Term: ABDOMEN -- Examination; Subject Term: NUCLEAR spectroscopy; Subject Term: RADIO frequency; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kiessling, Connie R.
AU - Jackson, Marc
AU - Watts, Kathleen A.
AU - Loftis, Mercedes H.
AU - Kiessling, William M.
AU - Buen, Marie B.
AU - Laster, Ebony W.
AU - Sofos, John N.
T1 - Antimicrobial Susceptibility of Salmonella Isolated from Various Products, from 1999 to 2003.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/06//
VL - 70
IS - 6
M3 - Article
SP - 1334
EP - 1338
SN - 0362028X
AB - Foodborne salmonellosis continues to be a major health concern worldwide; thus, detection and tracking of antimicrobial resistance in Salmonella isolates is of interest. The U.S. Food and Drug Administration initiated antimicrobial sensitivity screening of Salmonella isolates from food and related samples in 1999. This paper summarizes the antimicrobial resistance data for Salmonella isolates obtained from 1999 to 2003. A total of 22,231 imported and domestic samples were analyzed for Salmonella, of which 1,319 (5.9%) yielded the pathogen. Since more than one culture was isolated from some samples, the total number of isolates obtained and tested for antimicrobial sensitivity was 1,382. Antimicrobial sensitivity screening was performed with the disc diffusion assay on 11 antimicrobial agents. Of the 1,108 food isolates screened, 42.1% (n = 467) were serotypes Weltevreden, Newport, Lexington, Senfienberg, Typhimurium, Saint Paul, Paratyphi, Enteritidis, Thompson, and Bareilly. A total of 249 (18.0%) isolates from all sources were resistant to two or more antimicrobials. Resistance to sulfisoxazole, streptomycin, and tetracycline was most common, whereas resistance to ciprofloxacin was least common. Weltevreden (n = 148) was the most common serotype isolated from food, but only nine (6.1%) of these isolates were resistant to two or more antimicrobials. In contrast, although Derby was recovered only 19 times, 11 (57.9 %) of these isolates were resistant to two or more antimicrobials. Of the 274 isolates from animal feed, dog treats and environmental swabs, 49.6% (n = 136) belonged to serotypes Infantis, Mbandaka, Anatum, Senftenberg, Typhimurium, Montevideo, Cerro, Enteritidis, and Bredeney, with 76 (27.7%) of these isolates resistant to two or more antimicrobials. Only limited trends in antimicrobial resistance were observed over time, with resistance to sulfisoxazole increasing, resistance to tetracycline decreasing, and resistance to streptomycin fluctuating. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella food poisoning
KW - Salmonella diseases
KW - Drug resistance in microorganisms
KW - Streptomycin
KW - Tetracycline
KW - Ciprofloxacin
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 25575860; Kiessling, Connie R. 1; Email Address: connie.kiessling@fda.hhs.gov; Jackson, Marc 1; Watts, Kathleen A. 1; Loftis, Mercedes H. 1; Kiessling, William M. 1; Buen, Marie B. 1; Laster, Ebony W. 1; Sofos, John N. 2; Affiliations: 1: Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087; 2: Department of Animal Sciences, Colorado State University, Fort Collins, Colorado 80523-1171, USA; Issue Info: Jun2007, Vol. 70 Issue 6, p1334; Subject Term: Salmonella food poisoning; Subject Term: Salmonella diseases; Subject Term: Drug resistance in microorganisms; Subject Term: Streptomycin; Subject Term: Tetracycline; Subject Term: Ciprofloxacin; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ye, S.
AU - Koutchma, T.
AU - Parisi, B.
AU - Larkin, J.
AU - Forney, L. J.
T1 - Ultraviolet Inactivation Kinetics of Escherichia coli and Yersinia pseudotuberculosis in Annular Reactors.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2007/06//Jun/Jul2007
VL - 72
IS - 5
M3 - Article
SP - E271
EP - E278
SN - 00221147
AB - Terrorist threats have precipitated the need for information on the ultraviolet (UV) resistance of potential biothreat agents in food processing, such as Yersinia pestis. The objective of this study was to characterize the resistance of the Yersinia species to UV treatment using a single-lamp annular UV reactor. A novel method is proposed to measure the inactivation kinetics of Yersinia pseudotuberculosis, a surrogate of Y. pestis. This proposed method can overcome the disadvantages of the traditional collimated beam approach for liquids with high absorptive properties, such as liquid foods. As a reference, an inactivation rate of Escherichia coli K12 in caramel model solutions was measured first. Both first-order and series-event inactivation models were used to fit UV inactivation data. For the series-event model, an inactivation constant of kSE= 0.675 cm2/mJ and threshold n= 4 were obtained for E. coli K12 with the coefficient of determination R2= 0.987 and the standard deviation of log10 reductions σ y= 0.133. For Y. pseudotuberculosis, kSE= 0.984 cm2/mJ and n= 3 were obtained with R2= 0.972 and σ y= 0.212. In contrast, for the first-order inactivation model, the first-order inactivation constant k1= 0.325 cm2/mJ with R2= 0.907 and σ y= 0.354 was found for E. coli; and k1= 0.557 cm2/mJ with R2= 0.916 and σ y= 0.402 was obtained for Y. pseudotuberculosis. Based on R2, σ y, and the maximum absolute and relative errors, the series-event inactivation model describes the UV inactivation kinetics of Y. pseudotuberculosis and E. coli better than the first-order model. It is apparent that Y. pseudotuberculosis is less resistant to UV light than E. coli K12. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YERSINIA pseudotuberculosis
KW - ESCHERICHIA coli
KW - ULTRAVIOLET lamps
KW - VIRUS inactivation
KW - FOOD industry
KW - absorption coefficient
KW - annular reactors
KW - Escherichia coli
KW - inactivation kinetics
KW - ultraviolet (UV) irradiation
KW - Yersinia pseudotuberculosis
N1 - Accession Number: 25490056; Ye, S. 1 Koutchma, T. 2; Email Address: koutchma@iit.edu Parisi, B. 2 Larkin, J. 3 Forney, L. J. 1; Affiliation: 1: Dept. of School of Chemical and Biomolecular Engineering, Georgia Inst. of Technology, 311 Ferst Drive, N.W., Atlanta, GA 30332, U.S.A. 2: Dept. of National Center for Food Safety and Technology, Illinois Inst. of Technology, 6502 South Archer Road, Summit-Agro, IL 60501, U.S.A. 3: Dept. of U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Agro, IL 60501, U.S.A.; Source Info: Jun/Jul2007, Vol. 72 Issue 5, pE271; Subject Term: YERSINIA pseudotuberculosis; Subject Term: ESCHERICHIA coli; Subject Term: ULTRAVIOLET lamps; Subject Term: VIRUS inactivation; Subject Term: FOOD industry; Author-Supplied Keyword: absorption coefficient; Author-Supplied Keyword: annular reactors; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: inactivation kinetics; Author-Supplied Keyword: ultraviolet (UV) irradiation; Author-Supplied Keyword: Yersinia pseudotuberculosis; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 335120 Lighting fixture manufacturing; NAICS/Industry Codes: 335129 Other Lighting Equipment Manufacturing; Number of Pages: 1p; Illustrations: 3 Diagrams, 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1111/j.1750-3841.2007.00397.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schier, Joshua G.
AU - Algren, Adam
T1 - Medical Toxicology and Public Health--Update on Research and Activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry.
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
Y1 - 2007/06//
VL - 3
IS - 2
M3 - Article
SP - 85
EP - 85
SN - 15569039
AB - The article offers updates on issues related to toxicology. An outbreak of acute renal failure with neurological symptoms caused by diethylene glycol contaminated cough syrup given to residents was reported in Panama. Meanwhile, an increased number of fentanyl-related deaths among illicit drug users was observed in Wayne County, Michigan.
KW - TOXICOLOGY
KW - ACUTE kidney failure
KW - DRUGS -- Toxicology
KW - FENTANYL
KW - PANAMA
KW - MICHIGAN
N1 - Accession Number: 25056616; Schier, Joshua G. 1 Algren, Adam 2; Affiliation: 1: U.S. Public Health Service, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention 2: Senior Medical Toxicology Fellow, Emory/CDC Medical Toxicology Fellowship, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention; Source Info: Jun2007, Vol. 3 Issue 2, p85; Subject Term: TOXICOLOGY; Subject Term: ACUTE kidney failure; Subject Term: DRUGS -- Toxicology; Subject Term: FENTANYL; Subject Term: PANAMA; Subject Term: MICHIGAN; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leggat, Peter A.
AU - Smith, Derek R.
T1 - Military Training and Musculoskeletal Disorders.
JO - Journal of Musculoskeletal Pain
JF - Journal of Musculoskeletal Pain
Y1 - 2007/06//
VL - 15
IS - 2
M3 - Article
SP - 25
EP - 32
SN - 10582452
AB - Objectives: This study examined the extent to which musculoskeletal disorders [MSD] affect military populations, as well as intrinsic and extrinsic factors associated with MSD and the relative contribution of training, sports, and manual handling. A search of published literature was conducted using PubMed-listed articles published up to February 2006. Findings: Although physical conditioning represents an important facet of military preparedness. up to half of all recruits may suffer an injury during their basic military training. Musculoskeletal disorders are a common occurrence for soldiers and represent an important source of morbidity for the military as a whole. Intrinsic risk factors linked to military training injuries include a diverse range of inherent variables such as the level of prior physical conditioning, psychological make up, age, height, weight, and gender. Extrinsic risk factors for military MSD include training surface, exercise when fatigued, progressive training in place of cyclical training, and the type of footwear usually worn. Other military-specific variables may also include drill methods. the arrangement of platoons, training technique, and the actual training distance. Conclusions: Overall, this review suggests that MSD arc a common occurrence for military personnel and represent an important source of morbidity for the military as a whole. In meeting this problem, there is clearly an urgent need to target effective preventive measures, especially those involving military-specific training and sports activities, [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Musculoskeletal Pain is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCULOSKELETAL system -- Diseases
KW - MILITARY personnel -- Diseases
KW - MILITARY education
KW - DISEASES -- Risk factors
KW - PHYSICAL therapy
KW - Military
KW - musculoskeletal disorders
KW - physiotherapy
KW - training, prevention
N1 - Accession Number: 25920781; Leggat, Peter A. 1 Smith, Derek R. 2,3; Email Address: smith@h.jniosh.go.jp; Affiliation: 1: Associate Professor, Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Australia 2: Staff Researcher, International Center for Research Promotion and Informatics Japan National Institute of Occupational Safety and Health 3: Adjunct Senior Research Fellow, Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Australia; Source Info: 2007, Vol. 15 Issue 2, p25; Subject Term: MUSCULOSKELETAL system -- Diseases; Subject Term: MILITARY personnel -- Diseases; Subject Term: MILITARY education; Subject Term: DISEASES -- Risk factors; Subject Term: PHYSICAL therapy; Author-Supplied Keyword: Military; Author-Supplied Keyword: musculoskeletal disorders; Author-Supplied Keyword: physiotherapy; Author-Supplied Keyword: training, prevention; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; NAICS/Industry Codes: 928110 National Security; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1300/J094v15n02_06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duling, Matthew G.
AU - Lawrence, Robert B.
AU - Slaven, James E.
AU - Coffey, Christopher C.
T1 - Simulated Workplace Protection Factors for Half-Facepiece Respiratory Protective Devices.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/06//
VL - 4
IS - 6
M3 - Article
SP - 420
EP - 431
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study investigates two different methods (random effects model and 5th percentile) for determining the performance of three types of respiratory protective devices (elastomeric N95 respirators, N95 filtering-facepiece respirators, and surgical masks) during a simulated workplace test. This study recalculated the protection level of three types of respiratory protective devices using the random effects model, compared the two methods with each other and the APF of 10 for half-facepiece respirators, and determined the value of each of the fit test protocols in attaining the desired level of simulated workplace protection factor (SWPF). Twenty-five test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020 and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. Each of the six tests produced an SWPF. To determine the level of protection provided by the respiratory protective devices, a 90% lower confidence limit for the simulated workplace protection factor (SWPFLCL90%) and the 5th percentile of simulated workplace protection factor were computed. The 5th percentile method values could be up to seven times higher than the SWPFLCL90% values. Without fit testing, all half-facepiece N95 respirators had a 5th percentile of 4.6 and an SWPFLCL90% value of 2.7. N95 filtering-facepiece respirators as a class had values of 3.3 and 2.0, respectively, whereas N95 elastomeric respirators had values of 7.3 and 4.6, respectively. Surgical masks did not provide any protection, with values of 1.2 and 1.4, respectively. Passing either the Bitrex, saccharin, or Companion fit test resulted in the respirators providing the expected level of protection with 5th percentiles greater than or equal to 10 except when passing the Bitrex test with N95 filtering-facepiece respirators, which resulted in a 5th percentile of only 7.9. No substantial difference was seen between the three fit tests. All of the SWPFLCL90% values after passing a fit test were less than 10. The random model method provides a more conservative estimate of the protection provided by a respirator because it takes into account both between- and within-wearer variability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Industrial hygiene
KW - Elastomers
KW - Breathing apparatus
KW - fit test
KW - N95 elastomeric respirators
KW - N95 filtering-facepiece respirators
KW - simulated workplace test
N1 - Accession Number: 75127770; Duling, Matthew G. 1; Lawrence, Robert B. 1; Slaven, James E. 2; Coffey, Christopher C. 1; Affiliations: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health. Morgantown, West Virginia; 2: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Health Effects Laboratory Division, National Institute for Occupational Safety and Health. Morgantown, West Virginia; Issue Info: Jun2007, Vol. 4 Issue 6, p420; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial hygiene; Thesaurus Term: Elastomers; Subject Term: Breathing apparatus; Author-Supplied Keyword: fit test; Author-Supplied Keyword: N95 elastomeric respirators; Author-Supplied Keyword: N95 filtering-facepiece respirators; Author-Supplied Keyword: simulated workplace test; NAICS/Industry Codes: 325212 Synthetic Rubber Manufacturing; NAICS/Industry Codes: 325211 Plastics Material and Resin Manufacturing; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/15459620701346925
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106180357
T1 - Simulated workplace protection factors for half-facepiece respiratory protective devices.
AU - Duling MG
AU - Lawrence RB
AU - Slaven JE
AU - Coffey CC
Y1 - 2007/06//
N1 - Accession Number: 106180357. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; CEU; equations & formulas; research; tables/charts. Note: For CE see Suppl pages D63-4. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Occupational Exposure -- Prevention and Control
KW - Respiratory Protective Devices -- Standards
KW - Adult
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Environmental Monitoring -- Equipment and Supplies
KW - Equipment Failure
KW - Female
KW - Male
KW - Middle Age
KW - Models, Statistical
KW - Work Environment
KW - Human
SP - 420
EP - 431
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study investigates two different methods (random effects model and 5th percentile) for determining the performance of three types of respiratory protective devices (elastomeric N95 respirators, N95 filtering-facepiece respirators, and surgical masks) during a simulated workplace test. This study recalculated the protection level of three types of respiratory protective devices using the random effects model, compared the two methods with each other and the APF of 10 for half-facepiece respirators, and determined the value of each of the fit test protocols in attaining the desired level of simulated workplace protection factor (SWPF). Twenty-five test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020 and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. Each of the six tests produced an SWPF. To determine the level of protection provided by the respiratory protective devices, a 90% lower confidence limit for the simulated workplace protection factor (SWPF(LCL90%)) and the 5th percentile of simulated workplace protection factor were computed. The 5th percentile method values could be up to seven times higher than the SWPF(LCL90%) values. Without fit testing, all half-facepiece N95 respirators had a 5th percentile of 4.6 and an SWPF(LCL90%) value of 2.7. N95 filtering-facepiece respirators as a class had values of 3.3 and 2.0, respectively, whereas N95 elastomeric respirators had values of 7.3 and 4.6, respectively. Surgical masks did not provide any protection, with values of 1.2 and 1.4, respectively. Passing either the Bitrex, saccharin, or Companion fit test resulted in the respirators providing the expected level of protection with 5th percentiles greater than or equal to 10 except when passing the Bitrex test with N95 filtering-facepiece respirators, which resulted in a 5th percentile of only 7.9. No substantial difference was seen between the three fit tests. All of the SWPF(LCL90%) values after passing a fit test were less than 10. The random model method provides a more conservative estimate of the protection provided by a respirator because it takes into account both between- and within-wearer variability.
SN - 1545-9624
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888; mwd1@cdc.gov
U2 - PMID: 17474032.
DO - 10.1080/15459620701346925
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106180357&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106142074
T1 - Medical fitness evaluation for respirator users: results of a national survey of private sector employers.
AU - Syamlal G
AU - Doney B
AU - Bang KM
AU - Greskevitch M
AU - Groce D
AU - Ganocy S
AU - Hoffman W
Y1 - 2007/06//
N1 - Accession Number: 106142074. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Occupational Diseases -- Prevention and Control
KW - Private Sector
KW - Respiratory Protective Devices -- Utilization
KW - Descriptive Statistics
KW - Equipment Safety
KW - Health Status
KW - Questionnaires
KW - Survey Research
KW - United States
KW - United States Occupational Safety and Health Administration -- Standards
KW - Human
SP - 691
EP - 699
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 49
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: To provide information on medical evaluation procedures for respirator use in private sector establishments. Methods: In 2001, data on respirator use and practices were collected in a survey of private sector establishments. Results: Of establishments where respirators were required, 46% did not evaluate employees' medical fitness. Evaluations for fitness increased with establishment size, ranging from 35% in small establishments (1-10 workers) to 95% in large establishments (1000 workers). Questionnaire with a follow-up examination, as needed, was the most common method of evaluating medical fitness (48%). Conclusions: Results suggest that about half of all private sector establishments where respirators are required do not comply with Occupational Safety and Health Administration requirements for medical fitness evaluations. Improved awareness among employers and workers and identification of methods to increase medical evaluation practices, especially among smaller establishments, is needed.
SN - 1076-2752
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mail Stop HG-900.2, Morgantown, WV 26505; gsyamlal@cdc.gov
U2 - PMID: 17563613.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106142074&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109848935
T1 - Putting the patient in patient safety.
AU - Clancy CM
Y1 - 2007/06//2007 Jun
N1 - Accession Number: 109848935. Language: English. Entry Date: 20080321. Revision Date: 20150923. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 101233393.
KW - Consumer Participation
KW - Patient Safety
KW - Medication Errors -- Prevention and Control
KW - Patient Education
SP - 65
EP - 66
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 3
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Director, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services, 540 Gaither Rd, Rockville, MD 20850; cclancy@ahrq.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109848935&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Snorek, Sharon M.
AU - Bauer, John F.
AU - Chidambaram, Nallaperumal
AU - Doub, William H.
AU - Duffy, Eric P.
AU - Etzler, Frank M.
AU - Kelly, Richard N.
AU - Lane, Justin J.
AU - Mueller, Ronald L.
AU - Prasanna, Hullahalli R.
AU - Pujara, Chetan P.
AU - Reif, Van D.
AU - Scarlett, Brian
AU - Stowell, Joseph G.
AU - Toma, Pascal H.
T1 - PQRI recommendations on particle-size analysis of drug substances used in oral dosage forms.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/06//
VL - 96
IS - 6
M3 - Article
SP - 1451
EP - 1467
SN - 00223549
AB - This document provides information for the Pharmaceutical Industry and the Federal Drug Administration (FDA) regarding the selection of suitable particle-size analysis techniques, development and validation of particle-size methods, and the establishment of acceptance criteria for the particle size of drug substances used in oral solid-dosage forms. The document is intended for analysts knowledgeable in the techniques necessary to conduct particle-size characterization (a table of acronyms is provided at the end of the document). It is acknowledged that each drug substance, formulation, and manufacturing process is unique and that multiple techniques and instruments are available to the analyst. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:1451–1467, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - INDUSTRIES
KW - HEALTH care industry
KW - DRUGS
KW - MEDICINE
KW - analysis
KW - image analysis
KW - light-scattering
KW - microscopy
KW - morphology
KW - particle size
N1 - Accession Number: 24891702; Snorek, Sharon M. 1; Email Address: snorek_sharon_m@lilly.com Bauer, John F. 2 Chidambaram, Nallaperumal 3 Doub, William H. 4 Duffy, Eric P. 3 Etzler, Frank M. 5 Kelly, Richard N. 6 Lane, Justin J. 7 Mueller, Ronald L. 8 Prasanna, Hullahalli R. 3 Pujara, Chetan P. 2 Reif, Van D. 9 Scarlett, Brian 10 Stowell, Joseph G. 11 Toma, Pascal H. 12; Affiliation: 1: Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285-0001 2: Abbott Laboratories, North Chicago, Illinois 60064-6293 3: Food and Drug Administration, Center for Drug Evaluation and Research, 5600 Fishers Lane, Rockville, Maryland 20857-1750 4: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, Missouri 63101-2043 5: Boehringer-Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368 6: Johnson & Johnson Pharmaceutical Research and Development, L.L.C., McKean & Welsh Roads, Spring House, Pennsylvania 19406-2711 7: United States Pharmacopeia and National Formulary, 12601 Twinbrook Parkway, Rockville, Maryland 20852-1717 8: GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406-2711 9: Schering-Plough Research Institute, 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-1310 10: University of Florida, 2000 SW Archer Road, Gainesville, Florida 32608-1136 11: The Chao Center, 3070 Kent Avenue, West Lafayette, Indiana 47906-1075 12: GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398; Source Info: Jun2007, Vol. 96 Issue 6, p1451; Subject Term: PHARMACEUTICAL industry; Subject Term: INDUSTRIES; Subject Term: HEALTH care industry; Subject Term: DRUGS; Subject Term: MEDICINE; Author-Supplied Keyword: analysis; Author-Supplied Keyword: image analysis; Author-Supplied Keyword: light-scattering; Author-Supplied Keyword: microscopy; Author-Supplied Keyword: morphology; Author-Supplied Keyword: particle size; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; Number of Pages: 17p; Illustrations: 4 Diagrams, 7 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24891702&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Corner, Freda
AU - Banerjee, Sudipto
AU - Carlin, Bradley P.
AU - Sinha, Debajyoti
T1 - Flexible Cure Rate Modeling Under Latent Activation Schemes.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2007/06//
VL - 102
IS - 478
M3 - Article
SP - 560
EP - 572
SN - 01621459
AB - With rapid improvements in medical treatment and health care, many datasets dealing with time to relapse or death now reveal a substantial portion of patients who are cured (i.e., who never experience the event). Extended survival models called cure rate models account for the probability of a subject being cured and can be broadly classified into the classical mixture models of Berkson and Gage (BG type) or the stochastic tumor models pioneered by Yakovlev and extended to a hierarchical framework by Chen, lbrahim, and Sinha (YCIS type). Recent developments in Bayesian hierarchical cure models have evoked significant interest regarding relationships and preferences between these two classes of models. Our present work proposes a unifying class of cure rate models that facilitates flexible hierarchical model-building while including both existing cure model classes as special cases. This unifying class enables robust modeling by accounting for uncertainty in Underlying mechanisms leading to cure. Issues such as regressing on the cure fraction and propriety of the associated posterior distributions under different modeling assumptions are also discussed. Finally, we offer a simulation study and also illustrate with two datasets (on melanoma and breast cancer) that reveal our framework's ability to distinguish among underlying mechanisms that lead to relapse and cure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BAYESIAN analysis
KW - MARKOV processes
KW - MONTE Carlo method
KW - ALGORITHMS
KW - MEDICAL care
KW - SURVIVAL analysis (Biometry)
KW - CANCER treatment
KW - BREAST cancer
KW - MELANOMA
KW - MEDICAL statistics
KW - Bayesian hierarchical model
KW - Cure fraction
KW - Cure rate model
KW - Latent activation scheme
KW - Markov chain Monte Carlo algorithm
KW - Moment-generating functions
KW - Survival analysis
N1 - Accession Number: 25292098; Corner, Freda 1; Banerjee, Sudipto 2; Email Address: sudiptob@biostat.umn.edu; Carlin, Bradley P. 3,4; Sinha, Debajyoti 5; Affiliations: 1: Mathematical Statistician in Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration; 2: Assistant Professor of Biostatistics, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455; 3: Professor of Biostatistics, Public Health, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455; 4: Mayo Professor, Public Health, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455; 5: Professor, Department of Biostatistics and Bioinformatics, Medical University of South Carolina, Charleston, SC 29425; Issue Info: Jun2007, Vol. 102 Issue 478, p560; Thesaurus Term: BAYESIAN analysis; Thesaurus Term: MARKOV processes; Thesaurus Term: MONTE Carlo method; Thesaurus Term: ALGORITHMS; Thesaurus Term: MEDICAL care; Subject Term: SURVIVAL analysis (Biometry); Subject Term: CANCER treatment; Subject Term: BREAST cancer; Subject Term: MELANOMA; Subject Term: MEDICAL statistics; Author-Supplied Keyword: Bayesian hierarchical model; Author-Supplied Keyword: Cure fraction; Author-Supplied Keyword: Cure rate model; Author-Supplied Keyword: Latent activation scheme; Author-Supplied Keyword: Markov chain Monte Carlo algorithm; Author-Supplied Keyword: Moment-generating functions; Author-Supplied Keyword: Survival analysis; Number of Pages: 13p; Illustrations: 5 Charts, 18 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=25292098&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Cooner, Freda
AU - Banerjee, Sudipto
AU - Carlin, Bradley P.
AU - Sinha, Debajyoti
AD - US Food and Drug Administration
AD - U MN
AD - U MN
AD - Medical U SC, Charleston
T1 - Flexible Cure Rate Modeling under Latent Activation Schemes
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2007/06//
VL - 102
IS - 478
SP - 560
EP - 572
SN - 01621459
N1 - Accession Number: 0918902; Publication Type: Journal Article; Update Code: 200707
N2 - With rapid improvements in medical treatment and health care, many datasets dealing with time to relapse or death now reveal a substantial portion of patients who are cured (i.e., who never experience the event). Extended survival models called cure rate models account for the probability of a subject being cured and can be broadly classified into the classical mixture models of Berkson and Gage (BG type) or the stochastic tumor models pioneered by Yakovlev and extended to a hierarchical framework by Chen, Ibrahim, and Sinha (YCIS type). Recent developments in Bayesian hierarchical cure models have evoked significant interest regarding relationships and preferences between these two classes of models. Our present work proposes a unifying class of cure rate models that facilitates flexible hierarchical model building while including both existing cure model classes as special cases. This unifying class enables robust modeling by accounting for uncertainty in underlying mechanisms leading to cure. Issues such as regressing on the cure fraction and propriety of the associated posterior distributions under different modeling assumptions are also discussed. Finally, we offer a simulation study and also illustrate with two datasets (on melanoma and breast cancer) that reveal our framework's ability to distinguish among underlying mechanisms that lead to relapse and cure.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0918902&site=ehost-live&scope=site
UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Vernon, John A.
AU - Manning, Richard L.
T1 - Editorial.
JO - Managerial & Decision Economics
JF - Managerial & Decision Economics
Y1 - 2007/06//
VL - 28
IS - 4/5
M3 - Article
SP - 229
EP - 229
SN - 01436570
AB - The author provides information about the June 1, 2007 issue of the journal "Managerial and Decision Economics." He commended several authors and pharmaceutical companies for contributing to the success of publishing the issue. The author also mentions topics written by researchers with a long and productive history in the analysis of economic and policy issues relating to pharmaceutical industry. Commentaries and reviews are also included.
KW - MANAGERIAL economics
KW - PHARMACEUTICAL industry
KW - ECONOMIC policy
KW - EDITORIALS
KW - PUBLICATIONS
KW - PERIODICALS
N1 - Accession Number: 26294750; Vernon, John A. 1,2; Manning, Richard L. 3; Affiliations: 1: Senior Economic Policy Advisor, Office of the Commissioner, U.S. Food and Drug Administration; 2: Department of Finance, School of Business, The University of Connecticut, USA; 3: Senior Director, Worldwide Public Affairs and Policy, Pfizer Inc; Issue Info: Jun2007, Vol. 28 Issue 4/5, p229; Thesaurus Term: MANAGERIAL economics; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: ECONOMIC policy; Subject Term: EDITORIALS; Subject Term: PUBLICATIONS; Subject Term: PERIODICALS; NAICS/Industry Codes: 519110 News Syndicates; NAICS/Industry Codes: 414420 Book, periodical and newspaper merchant wholesalers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 424920 Book, Periodical, and Newspaper Merchant Wholesalers; NAICS/Industry Codes: 451310 Book stores and news dealers; NAICS/Industry Codes: 451212 News Dealers and Newsstands; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 1p; Document Type: Article
L3 - 10.1002/mde.1336
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=26294750&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Higgins, Karen J.
AU - Reid, Phyllis M.
AU - Going, Scott B.
AU - Howell, Wanda H.
T1 - Validation of Bioimpedance Spectroscopy to Assess Acute Changes in Hydration Status.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2007/06//
VL - 39
IS - 6
M3 - Article
SP - 984
EP - 990
SN - 01959131
AB - The article aims to validate the efficiency of bioimpedance spectroscopy in measuring small and acute changes in extracellular water (ECW) during fluid fast/rehydration manipulation. The authentication process underwent through fluid fast/rehydration manipulation to induce acute changes in ECW. Results reveal that bioimpedance spectroscopy (BIS-▵ECW) and bromide dilution were the same during dehydration regardless of the hydration status. BIS-▵ECW was likewise found to be correlative with the change in body weight. Based from the findings, it resolves that BIS provides accurate estimates of ECW changes than bromide dilution.
KW - EXTRACELLULAR fluid
KW - HYDRATION
KW - BIOELECTRIC impedance
KW - DILUTION
KW - SPECTRUM analysis
KW - PHASE transformations (Physics)
KW - DEHYDRATION (Physiology)
KW - BODY weight
KW - BROMIDES
KW - body weight
KW - bromide dilution
KW - dehydration
KW - extracellular water
KW - rehydration
N1 - Accession Number: 25382710; Higgins, Karen J. 1,2 Reid, Phyllis M. 1 Going, Scott B. 1 Howell, Wanda H. 1; Email Address: whhowell@agarizona.edu; Affiliation: 1: Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 2: Tucson Area Indian Health Service, US. Department of Health and Human Services, Tucson, AZ; Source Info: Jun2007, Vol. 39 Issue 6, p984; Subject Term: EXTRACELLULAR fluid; Subject Term: HYDRATION; Subject Term: BIOELECTRIC impedance; Subject Term: DILUTION; Subject Term: SPECTRUM analysis; Subject Term: PHASE transformations (Physics); Subject Term: DEHYDRATION (Physiology); Subject Term: BODY weight; Subject Term: BROMIDES; Author-Supplied Keyword: body weight; Author-Supplied Keyword: bromide dilution; Author-Supplied Keyword: dehydration; Author-Supplied Keyword: extracellular water; Author-Supplied Keyword: rehydration; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kotewicz, Michael L.
AU - Jackson, Scott A.
AU - Leclerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Optical maps distinguish individual strains of Escherichia coIi O157 : H7.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2007/06//
VL - 153
IS - 6
M3 - Article
SP - 1720
EP - 1733
SN - 13500872
AB - The article presents microbiological research into optical maps that distinguish individual strains of the Escherichia coli O157:H7 pathogenic microorganism. Optical maps were generated by the assembly of restriction fragments across the entire chromosomes. The maps revealed unique bacterial genome landmarks in the strains.
KW - Escherichia coli
KW - Pathogenic microorganisms
KW - Pathogenic bacteria
KW - Bacterial genetics
KW - Microbiological research
KW - Gene mapping
N1 - Accession Number: 25495712; Kotewicz, Michael L. 1; Jackson, Scott A. 1; Leclerc, J. Eugene 1; Cebula, Thomas A. 1; Email Address: ThomasCebula@fdahhs.gov; Affiliations: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Jun2007, Vol. 153 Issue 6, p1720; Thesaurus Term: Escherichia coli; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Pathogenic bacteria; Thesaurus Term: Bacterial genetics; Subject Term: Microbiological research; Subject Term: Gene mapping; Number of Pages: 14p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1099/mic.0.2006/004507-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25495712&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Boyko, Alex
AU - Rodriguez-Juarez, Rocio
AU - Beland, Frederick A.
AU - Kovalchuk, Olga
T1 - Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2007/06//
VL - 619
IS - 1/2
M3 - Article
SP - 30
EP - 37
SN - 00275107
AB - Abstract: Micro RNAs (miRNAs) are small non-coding RNA molecules that function as negative regulators of gene expression. They play a crucial role in the regulation of genes involved in the control of development, cell proliferation, apoptosis, and stress response. Although miRNA levels are substantially altered in tumors, their role in carcinogenesis, specifically at the early pre-cancerous stages, has not been established. Here we report that exposure of Fisher 344 rats to tamoxifen, a potent hepatocarcinogen in rats, for 24 weeks leads to substantial changes in the expression of miRNA genes in the liver. We noted a significant up-regulation of known oncogenic miRNAs, such as the 17-92 cluster, miR-106a, and miR-34. Furthermore, we confirmed the corresponding changes in the expression of proteins targeted by these miRNAs, which include important cell cycle regulators, chromatin modifiers, and expression regulators implicated in carcinogenesis. All these miRNA changes correspond to previously reported alterations in full-fledged tumors, including hepatocellular carcinomas. Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMORS
KW - GENES
KW - ONCOLOGY
KW - CARCINOGENESIS
KW - Hepatocarcinogenesis
KW - MiRNAs
KW - Rat
KW - Tamoxifen
N1 - Accession Number: 24868356; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Tryndyak, Volodymyr P. 1 Boyko, Alex 2 Rodriguez-Juarez, Rocio 2 Beland, Frederick A. 1 Kovalchuk, Olga 2; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States 2: Department of Biological Sciences, University of Lethbridge, Lethbridge AB T1K 3M4, Canada; Source Info: Jun2007, Vol. 619 Issue 1/2, p30; Subject Term: TUMORS; Subject Term: GENES; Subject Term: ONCOLOGY; Subject Term: CARCINOGENESIS; Author-Supplied Keyword: Hepatocarcinogenesis; Author-Supplied Keyword: MiRNAs; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Tamoxifen; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2006.12.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24868356&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fadeel, Bengt
AU - Kagan, Valerian
AU - Krug, Harald
AU - Shvedova, Anna
AU - Svartengren, Magnus
AU - Tran, Lang
AU - Wiklund, Lars
T1 - There's plenty of room at the forum: Potential risks and safety assessment of engineered nanomaterials.
JO - Nanotoxicology
JF - Nanotoxicology
Y1 - 2007/06//
VL - 1
IS - 2
M3 - Article
SP - 73
EP - 84
SN - 17435390
AB - The celebrated physicist and Nobel laureate Richard Feynman was the first to predict the opportunities presented by the manipulation of matter at the level of individual atoms and molecules. Today, almost 50 years after his classic lecture on the wonders of the small world, the evolving nanotechnologies have the potential to bring about major changes in the lives of citizens. However, the very same properties that make engineered nanomaterials so promising from a technological perspective, such as their high degree of reactivity and the ability to cross biological barriers, could also make these novel materials harmful to human health and the environment. Therefore, exploitation of the full potential of the nanotechnologies requires close attention to safety issues. The 1st Nobel Forum mini-symposium on nanotoxicology was recently held in Stockholm, Sweden, and the program was devoted to the topic of definitions and standardization in nanotoxicological research, as well as nano-specific risk assessment and regulatory/legislative issues. Examples of recent and ongoing studies of carbon-based nanomaterials, including single-walled carbon nanotubes, using a wide range of in vitro and in vivo model systems were also presented. The current review will provide some highlights and conclusions from this exciting meeting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nanotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOTECHNOLOGY
KW - CARBON nanotubes
KW - RISK assessment
KW - HEALTH
KW - ATOMS
KW - MOLECULES
KW - carbon nanotubes
KW - inflammation
KW - Nanotoxicology
KW - pulmonary exposure
KW - risk assessment
KW - FEYNMAN, Richard Phillips, 1918-1988
N1 - Accession Number: 26447124; Fadeel, Bengt 1; Email Address: bengt.fadeel@ki.se Kagan, Valerian 2 Krug, Harald 3 Shvedova, Anna 4 Svartengren, Magnus 5 Tran, Lang 6 Wiklund, Lars 7; Affiliation: 1: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 3: Division of Materials Science & Technology, Swiss Federal Laboratories for Materials Testing and Research (EMPA), St. Gallen, Switzerland 4: Pathology & Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH),,Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA 5: Department of Public Health Sciences, Karolinska Institutet, and Division of Occupational and Environmental Health, Stockholm County Council, Karolinska University Hospital, Stockholm, Sweden 6: Institute of Occupational Medicine, Edinburgh, UK 7: Swedish Society of Toxicology (SFT), and Regulatory Safety Sciences (RegSafe), Stockholm, Sweden; Source Info: Jun2007, Vol. 1 Issue 2, p73; Subject Term: NANOTECHNOLOGY; Subject Term: CARBON nanotubes; Subject Term: RISK assessment; Subject Term: HEALTH; Subject Term: ATOMS; Subject Term: MOLECULES; Author-Supplied Keyword: carbon nanotubes; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: Nanotoxicology; Author-Supplied Keyword: pulmonary exposure; Author-Supplied Keyword: risk assessment; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; People: FEYNMAN, Richard Phillips, 1918-1988; Number of Pages: 12p; Illustrations: 2 Color Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1080/17435390701565578
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sager, Tina M.
AU - Porter, Dale W.
AU - Robinson, Victor A.
AU - Lindsley, William G.
AU - Schwegler-Berry, Diane E.
AU - Castranova, Vincent
T1 - Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity.
JO - Nanotoxicology
JF - Nanotoxicology
Y1 - 2007/06//
VL - 1
IS - 2
M3 - Article
SP - 118
EP - 129
SN - 17435390
AB - Nanoparticles agglomerate and clump in solution, making it difficult to accurately deliver them for in vivo or in vitro experiments. Thus, experiments were conducted to determine the best method to suspend nanosized particles. Ultrafine and fine carbon black and titanium dioxide were suspended in phosphate buffered saline (PBS), rat and mouse bronchoalveolar lavage fluid (BALF), and PBS containing dipalmitoyl phosphatidylcholine (DPPC) and/or mouse serum albumin. To assess and compare how these various suspension media dispersed the nanoparticles, images were taken using light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results of this study show that PBS is not a satisfactory medium to prepare nanoparticle suspensions. However, BALF was an excellent media in which to suspend nanoparticles. The use of PBS containing protein or DPPC alone, in concentrations found in BALF, did not result in satisfactory particle dispersion. However, PBS-containing protein plus DPPC was satisfactory, although less effective than BALF. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nanotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - TITANIUM dioxide
KW - SERUM albumin
KW - BRONCHOALVEOLAR lavage
KW - SCANNING electron microscopy
KW - TRANSMISSION electron microscopy
KW - agglomeration
KW - bronchoalveolar lavage fluid
KW - carbon black
KW - dispersion
KW - Nanoparticles
KW - titanium dioxide
N1 - Accession Number: 26447120; Sager, Tina M. 1,2 Porter, Dale W. 1,2 Robinson, Victor A. 1 Lindsley, William G. 1 Schwegler-Berry, Diane E. 1 Castranova, Vincent 1,2; Email Address: vic1@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, USA; Source Info: Jun2007, Vol. 1 Issue 2, p118; Subject Term: NANOPARTICLES; Subject Term: TITANIUM dioxide; Subject Term: SERUM albumin; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: SCANNING electron microscopy; Subject Term: TRANSMISSION electron microscopy; Author-Supplied Keyword: agglomeration; Author-Supplied Keyword: bronchoalveolar lavage fluid; Author-Supplied Keyword: carbon black; Author-Supplied Keyword: dispersion; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: titanium dioxide; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 12p; Illustrations: 3 Black and White Photographs, 5 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1080/17435390701381596
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
AU - Griffin, Joseph
AU - Behrman, Rachel
AU - Cherney, Barry
AU - Crescenzi, Terrie
AU - Fraser, Blair
AU - Hixon, Dena
AU - Joneckis, Christopher
AU - Kozlowski, Steven
AU - Rosenberg, Amy
AU - Schrager, Lewis
AU - Shacter, Emily
AU - Temple, Robert
AU - Webber, Keith
AU - Winkle, Helen
T1 - The FDA's assessment of follow-on protein products: a historical perspective.
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2007/06//
VL - 6
IS - 6
M3 - journal article
SP - 437
EP - 442
PB - Nature Publishing Group
SN - 14741776
AB - The scientific and regulatory issues that are associated with the possible introduction of 'follow-on' versions of protein drug products are the topic of considerable debate at present. Because of the differences between protein drug products and small-molecule drugs, the development of follow-on versions of protein products presents more complex scientific challenges than those presented by the development of generic versions of small-molecule drugs. Here, with a view to illustrating the Food and Drug Administration's (FDA's) scientific reasoning and experience in this area, we discuss past examples of the FDA's actions involving the evaluation of various types of follow-on and second-generation protein products and within-product manufacturing changes. The FDA believes its evaluation of the safety and effectiveness of follow-on protein products will evolve as scientific and technological advances in product characterization and manufacturing continue to reduce some of the complexity and uncertainty that are inherent in the manufacturing of protein products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN drugs
KW - EXPERIMENTAL medicine
KW - THERAPEUTICS
KW - MEDICAL care
KW - PHARMACOLOGY
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 25265039; Woodcock, Janet 1; Email Address: janet.woodcock@fda.hhs.gov Griffin, Joseph 1 Behrman, Rachel 1 Cherney, Barry 1 Crescenzi, Terrie 1 Fraser, Blair 1 Hixon, Dena 1 Joneckis, Christopher 1 Kozlowski, Steven 1 Rosenberg, Amy 1 Schrager, Lewis 1 Shacter, Emily 1 Temple, Robert 1 Webber, Keith 1 Winkle, Helen 1; Affiliation: 1: Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA; Source Info: Jun2007, Vol. 6 Issue 6, p437; Subject Term: PROTEIN drugs; Subject Term: EXPERIMENTAL medicine; Subject Term: THERAPEUTICS; Subject Term: MEDICAL care; Subject Term: PHARMACOLOGY; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 6p; Document Type: journal article
L3 - 10.1038/nrd2307
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106106468
T1 - Tobacco smoking habits among a complete cross-section of Australian nursing students.
AU - Smith DR
AU - Leggat PA
Y1 - 2007/06//
N1 - Accession Number: 106106468. Language: English. Entry Date: 20070622. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Asia; Nursing; Peer Reviewed. NLM UID: 100891857.
KW - Habits
KW - Smoking -- Epidemiology
KW - Students, Nursing
KW - Adolescence
KW - Adult
KW - Australia
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Female
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - One-Way Analysis of Variance
KW - Prevalence
KW - Questionnaires
KW - Schools, Nursing
KW - Student Attitudes
KW - Human
SP - 82
EP - 89
JO - Nursing & Health Sciences
JF - Nursing & Health Sciences
JA - NURS HEALTH SCI
VL - 9
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1441-0745
AD - National Institute of Occupational Safety and Health, Kawasaki, Japan and Anton Breinl Center for Public Health and Tropical Medicine, James Cook University, Townsville, Australia.
U2 - PMID: 17470180.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105829800
T1 - FDA drug approval summary: bevacizumab AVASTIN plus carboplatin and paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer.
AU - Cohen MH
AU - Gootenberg J
AU - Keegan P
AU - Pazdur R
Y1 - 2007/06//
N1 - Accession Number: 105829800. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Carcinoma, Non-Small-Cell Lung -- Drug Therapy
KW - Lung Neoplasms -- Drug Therapy
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Antibodies, Monoclonal -- Administration and Dosage
KW - Antibodies, Monoclonal -- Adverse Effects
KW - Antineoplastic Agents, Combined -- Adverse Effects
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Carboplatin -- Administration and Dosage
KW - Carboplatin -- Adverse Effects
KW - Carcinoma, Non-Small-Cell Lung -- Pathology
KW - Clinical Trials
KW - Drug Approval
KW - Headache -- Chemically Induced
KW - Lung Neoplasms -- Pathology
KW - Middle Age
KW - Multicenter Studies
KW - Neoplasm Metastasis
KW - Neoplasm Staging
KW - Paclitaxel -- Administration and Dosage
KW - Paclitaxel -- Adverse Effects
KW - Pain -- Chemically Induced
KW - Treatment Outcomes
KW - United States
KW - United States Food and Drug Administration
KW - Vomiting -- Chemically Induced
SP - 713
EP - 718
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 12
IS - 6
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On October 11, 2006, the U.S. Food and Drug Administration granted approval for bevacizumab (Avastin(R); Genentech, Inc., South San Francisco, CA), administered in combination with carboplatin and paclitaxel, for the initial treatment of patients with unresectable, locally advanced, recurrent, or metastatic, nonsquamous, non-small cell lung cancer (NSCLC). Approval is based on a significant improvement in overall survival (OS). A randomized, open label, multicenter clinical trial, conducted by the Eastern Cooperative Oncology Group (ECOG), in chemotherapy-naïve patients with stage IIIB/IV nonsquamous NSCLC, evaluated bevacizumab plus carboplatin and paclitaxel (BV/CP, n = 434) versus carboplatin and paclitaxel alone (CP, n = 444). Exclusion of patients with squamous or predominantly squamous histology was based on life-threatening or fatal hemoptysis occurring in 4 of 13 patients with squamous histology who received a BV/CP regimen in a phase II study. Among the 878 randomized patients, the median age was 63, 46% were female, 76% had stage IV disease, 12% had stage IIIB disease with malignant pleural effusion, 11% had recurrent disease, and 40% had an ECOG performance status score of 0. OS was significantly longer in patients receiving BV/CP than in those receiving CP alone (median OS, 12.3 versus 10.3 months; hazard ratio [HR], 0.80; p = .013, stratified log rank test). Although a consistent effect was observed across most subgroups, in an exploratory analysis, evidence of a survival benefit was not observed in women (HR, 0.99; 95% confidence interval, 0.79-1.25). Severe and life-threatening adverse events occurring more frequently in patients receiving BV/CP were neutropenia (27% versus 17%), fatigue (16% versus 13%), hypertension (8% versus 0.7%), infection without neutropenia (7% versus 3%), thrombosis/embolism (5% versus 3%), pneumonitis or pulmonary infiltrate (5% versus 3%), infection with grade 3 or 4 neutropenia (5% versus 2%), febrile neutropenia (5% versus 2%), hyponatremia (4% versus 1%), proteinuria (3% versus 0), and headache (3% versus 0.5%). Fatal, treatment-related adverse events in patients receiving bevacizumab were pulmonary hemorrhage (2.3% versus 0.5%), gastrointestinal hemorrhage, central nervous system infarction, gastrointestinal perforation, myocardial infarction, and neutropenic sepsis. The most serious, and sometimes fatal, bevacizumab toxicities are gastrointestinal perforation, wound healing complications, hemorrhage, arterial thromboembolic events, hypertensive crisis, nephrotic syndrome, congestive heart failure, and neutropenic sepsis. The most common adverse events in patients receiving bevacizumab are asthenia, pain, abdominal pain, headache, hypertension, diarrhea, nausea, vomiting, anorexia, stomatitis, constipation, upper respiratory infection, epistaxis, dyspnea, exfoliative dermatitis, and proteinuria. Disclosure of potential conflicts of interest is found at the end of this article.
SN - 1083-7159
AD - U.S. Food and Drug Administration, White Oak Campus, 10903 New Hampshire Avenue, Building 22, Room 2102, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov.
U2 - PMID: 17602060.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McMahon, A. W.
AU - Zinderman, C.
AU - Ball, R.
AU - Gupta, G.
AU - Braun, M. M.
T1 - Comparison of military and civilian reporting rates for smallpox vaccine adverse events.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/06//
VL - 16
IS - 6
M3 - Article
SP - 597
EP - 604
SN - 10538569
AB - Introduction US smallpox vaccination (SMA) started most recently in December 2002. Military and civilian personnel report adverse events (AEs) to the Vaccine Adverse Event Reporting System (VAERS), a surveillance system that relies on spontaneous reports. Although reported rates of probable myo/pericarditis after SMA in the literature are similar between military personnel and civilian healthcare workers, some civilian AE reporting rates after SMA appeared higher than those in the military. Objective Determine if SMA-associated reporting rates are different in civilians than in the military, considering age, sex, seriousness, and expectedness of the AE, as well as self-reporting. Methods Numerators were SMA reports in VAERS from 12/12/02 to 3/1/04. Limitations of VAERS include underreporting and lack of diagnostic confirmation. Denominators were number of military and civilian vaccinees. Results Reporting rates stratified by age and sex of serious and non-serious AEs were significantly higher in civilian than military personnel ages <55 years (rate ratios 4-27). These rate ratios decreased with increasing age. Conclusions Reporting rates in VAERS differed significantly and substantially in civilians compared to military personnel <55 years of age. Differences in stimulated passive surveillance systems, and AE reporting practices, including the 'threshold' for reporting most likely explain these findings. These results suggest that in the case of smallpox vaccine AEs, there may be systematic differences in reporting completeness between the civilian and military sectors, and that passive surveillance data should be interpreted with caution. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708207; McMahon, A. W. 1; Zinderman, C. 1; Ball, R. 1; Gupta, G. 1; Braun, M. M. 1; Affiliations: 1: Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, MD, USA; Issue Info: Jun2007, Vol. 16 Issue 6, p597; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1349
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, J. J.
AU - Wang, S.-J.
AU - Tsai, C.-A.
AU - Lin, C.-J.
T1 - Selection of differentially expressed genes in microarray data analysis.
JO - Pharmacogenomics Journal
JF - Pharmacogenomics Journal
Y1 - 2007/06//
VL - 7
IS - 3
M3 - Article
SP - 212
EP - 220
PB - Nature Publishing Group
SN - 1470269X
AB - One common objective in microarray experiments is to identify a subset of genes that express differentially among different experimental conditions, for example, between drug treatment and no drug treatment. Often, the goal is to determine the underlying relationship between poor versus good gene signatures for identifying biological functions or predicting specific therapeutic outcomes. Because of the complexity in studying hundreds or thousands of genes in an experiment, selection of a subset of genes to enhance relationships among the underlying biological structures or to improve prediction accuracy of clinical outcomes has been an important issue in microarray data analysis. Selection of differentially expressed genes is a two-step process. The first step is to select an appropriate test statistic and compute the P-value. The genes are ranked according to their P-values as evidence of differential expression. The second step is to assign a significance level, that is, to determine a cutoff threshold from the P-values in accordance with the study objective. In this paper, we consider four commonly used statistics, t-, S- (SAM), U-(Mann–Whitney) and M-statistics to compute the P-values for gene ranking. We consider the family-wise error and false discovery rate false-positive error-controlled procedures to select a limited number of genes, and a receiver-operating characteristic (ROC) approach to select a larger number of genes for assigning the significance level. The ROC approach is particularly useful in genomic/genetic profiling studies. The well-known colon cancer data containing 22 normal and 40 tumor tissues are used to illustrate different gene ranking and significance level assignment methods for applications to genomic/genetic profiling studies. The P-values computed from the t-, U- and M-statistics are very similar. We discuss the common practice that uses the P-value, false-positive error probability, as the primary criterion, and then uses the fold-change as a surrogate measure of biological significance for gene selection. The P-value and the fold-change can be pictorially shown simultaneously in a volcano plot. We also address several issues on gene selection.The Pharmacogenomics Journal (2007) 7, 212–220. doi:10.1038/sj.tpj.6500412; published online 29 August 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacogenomics Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - THERAPEUTICS
KW - DNA microarrays
KW - STATISTICS
KW - TUMORS
KW - TISSUES
KW - fold-change
KW - gene ranking
KW - P-value
KW - permutation test
KW - volcano plot
N1 - Accession Number: 25130642; Chen, J. J. 1; Email Address: jchen@nctr.fda.gov Wang, S.-J. 2 Tsai, C.-A. 3 Lin, C.-J. 1; Affiliation: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA 2: Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA 3: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan; Source Info: 2007, Vol. 7 Issue 3, p212; Subject Term: GENES; Subject Term: THERAPEUTICS; Subject Term: DNA microarrays; Subject Term: STATISTICS; Subject Term: TUMORS; Subject Term: TISSUES; Author-Supplied Keyword: fold-change; Author-Supplied Keyword: gene ranking; Author-Supplied Keyword: P-value; Author-Supplied Keyword: permutation test; Author-Supplied Keyword: volcano plot; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1038/sj.tpj.6500412
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106000425
T1 - Guest editorial.
AU - del Vecchio P
AU - Fricks L
Y1 - 2007///Summer2007
N1 - Accession Number: 106000425. Language: English. Entry Date: 20080229. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9601800.
KW - Patient Centered Care
KW - Recovery
KW - Rehabilitation, Psychosocial
KW - Empowerment
KW - Mental Health Personnel
SP - 7
EP - 8
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 31
IS - 1
CY - Washington, District of Columbia
PB - American Psychological Association
SN - 1095-158X
AD - Associate Director, Consumer Affairs, Center for Mental Health Services, Department of Health and Human Services
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106000432
T1 - Promoting the value and practice of shared decision-making in mental health care.
AU - Schauer C
AU - Everett A
AU - del Vecchio P
AU - Anderson L
Y1 - 2007///Summer2007
N1 - Accession Number: 106000432. Language: English. Entry Date: 20080229. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9601800.
KW - Behavioral Sciences
KW - Consumer Participation -- Psychosocial Factors
KW - Decision Making
KW - Health Promotion -- Methods
KW - Mental Disorders -- Rehabilitation
KW - Mental Health Services -- Administration
KW - Psychiatric Patients -- Psychosocial Factors
KW - Consumer Participation -- Methods
KW - Consumer Participation -- Trends
KW - Health Promotion -- Trends
KW - Physician-Patient Relations
KW - United States
SP - 54
EP - 61
JO - Psychiatric Rehabilitation Journal
JF - Psychiatric Rehabilitation Journal
JA - PSYCHIATR REHABIL J
VL - 31
IS - 1
CY - Washington, District of Columbia
PB - American Psychological Association
AB - Active consumer participation is critical in contemporary mental health care and treatment planning and has been a staple of the field of psychiatric rehabilitation for the last three decades. Providing the opportunity for consumers to chose interventions that fit personal preferences and recovery increase the likelihood that these interventions will enhance personal meaning, satisfaction and quality of life (Improving the Quality of Health Care for Mental and Substance Use Conditions, 2006). Similarly, self-determination and shared decision-making are critical components of recovery. As stated in the President's New Freedom Commission on Mental Health Final Report, recovery from mental illnesses should be the expectation in mental health care with services and treatments that are consumer and family-driven. Mental health care should be planned and delivered to ensure that consumers and families with children with mental health problems receive real and meaningful choices about treatment options and providers. The purpose of this paper is to explore the value and use of shared decision-making in health and mental health care, briefly examine the advantages and disadvantages of shared decision making and propose next steps in advancing use of shared decision-making in mental health care.
SN - 1095-158X
AD - Senior Consumer Affairs Specialist, Center for Mental Health Services, SAMHSA, 1 Choke Cherry Road, Rm. 6-1067, Rockville MD 20857; carole.schauer@samhsa.hhs.gov
U2 - PMID: 17694716.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jae Byun, Young
AU - Hong, S.I.
AU - Kim, K.B.
AU - Jeon, D.H.
AU - Kim, J.M.
AU - Whiteside, W.S.
AU - Jin Park, Hyun
T1 - Physical and chemical properties of γ-irradiated EVOH film
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2007/06//
VL - 76
IS - 6
M3 - Article
SP - 974
EP - 981
SN - 0969806X
AB - Abstract: The effects of γ-irradiation on ethylene vinyl alcohol copolymer (EVOH) were investigated. Oxygen permeability decreased as irradiation dose increased in non-oriented (EF-CR), biaxially oriented (EF-XL) EVOH, and nylon/EVOH/PP. Irradiation increased tensile strength (TS) and elongation at break (%E) of EF-CR; whereas, TS of EF-XL was not significantly changed and %E of EF-XL decreased. Irradiation had no effect on TS and %E of nylon/EVOH/PP. Four volatile compounds, ε-caprolactam, 2-propyldecanol, 2-butyloctanol, and 2,3-diethyl-2,3-dimethyl-1,4-butanediol, were detected after irradiation. Optical properties were not changed. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IRRADIATION
KW - PHOTOSYNTHETIC oxygen evolution
KW - POLYAMIDES
KW - NYLON
KW - γ-irradiation
KW - EVOH
KW - Free volume
KW - Oxygen permeability
KW - Physicochemical property changes
N1 - Accession Number: 24611004; Jae Byun, Young 1 Hong, S.I. 1 Kim, K.B. 2 Jeon, D.H. 3 Kim, J.M. 4 Whiteside, W.S. 5 Jin Park, Hyun 1,5; Email Address: hjpark@korea.ac.kr; Affiliation: 1: Graduate School of Biotechnology, Korea University, 5-Ka, Anam-dong, Sungbuk-Gu, Seoul 136 701, Republic of Korea 2: Eesang Co.Ltd. 45-1, Namsan-Ri, Cheonan-Si, Chungnam 330 810, Republic of Korea 3: Food Packaging Division, Korea Food and Drug Administration (KFDA), 5 Nokbun-Dong, Eunpyung-Ku, Seoul 122 704, Republic of Korea 4: Ottogi Co.Ltd., Pyenogchon-Dong, Anyang, Republic of Korea 5: Department of Packaging Science, Clemson University, Clemson, SC 29634 0370, USA; Source Info: Jun2007, Vol. 76 Issue 6, p974; Subject Term: IRRADIATION; Subject Term: PHOTOSYNTHETIC oxygen evolution; Subject Term: POLYAMIDES; Subject Term: NYLON; Author-Supplied Keyword: γ-irradiation; Author-Supplied Keyword: EVOH; Author-Supplied Keyword: Free volume; Author-Supplied Keyword: Oxygen permeability; Author-Supplied Keyword: Physicochemical property changes; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 313110 Fiber, Yarn, and Thread Mills; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.radphyschem.2006.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24611004&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, James J.
AU - Moon, Hojin
AU - Kodell, Ralph L.
T1 - A probabilistic framework for non-cancer risk assessment
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/06//
VL - 48
IS - 1
M3 - Article
SP - 45
EP - 50
SN - 02732300
AB - Abstract: Risk assessment involves an analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level or to estimate a low-dose risk. Acceptable levels of human exposure for non-cancer effects generally are derived by dividing an experimental no-observed-adverse-effect-level or a lower confidence limit benchmark dose by a product of several uncertainty factors. This paper presents a hierarchical modeling framework for a probabilistic approach to non-cancer risk assessment. The hierarchical model integrates the distributions of uncertainty factors and the distribution of the actual exposure level to construct the dose–response model for the proportion of population at risk and the dose–response model for the expected proportion of population at risk for a given exposure distribution. The proposed approach is based on the use of the BMDL (lower confidence limit on the benchmark dose) as a POD (point of departure) for risk assessment of non-cancer effects. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Cancer
KW - Investment policy
KW - Evaluation
KW - Benchmark dose
KW - Distribution of exposure
KW - Hierarchical model
KW - Interspecies and intraspecies uncertainties
KW - Point of departure
N1 - Accession Number: 25183021; Chen, James J.; Email Address: jchen@nctr.fda.gov; Moon, Hojin 1; Kodell, Ralph L. 1; Affiliations: 1: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Issue Info: Jun2007, Vol. 48 Issue 1, p45; Thesaurus Term: Risk assessment; Subject Term: Cancer; Subject Term: Investment policy; Subject Term: Evaluation; Author-Supplied Keyword: Benchmark dose; Author-Supplied Keyword: Distribution of exposure; Author-Supplied Keyword: Hierarchical model; Author-Supplied Keyword: Interspecies and intraspecies uncertainties; Author-Supplied Keyword: Point of departure; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.yrtph.2006.10.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25183021&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105963654
T1 - An example of US Food and Drug Administration device regulation: medical devices indicated for use in acute ischemic stroke.
AU - Peña C
AU - Li K
AU - Felten R
AU - Ogden N
AU - Melkerson M
AU - Peña, Carlos
AU - Li, Khan
AU - Felten, Richard
AU - Ogden, Neil
AU - Melkerson, Mark
Y1 - 2007/06//
N1 - Accession Number: 105963654. Language: English. Entry Date: 20080208. Revision Date: 20161126. Publication Type: journal article; review. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Physical Therapy. NLM UID: 0235266.
KW - Cerebral Ischemia -- Therapy
KW - Device Approval
KW - United States Food and Drug Administration -- Trends
KW - Acute Disease
KW - Animals
KW - Cerebral Ischemia -- Epidemiology
KW - United States
SP - 1988
EP - 1992
JO - Stroke (00392499)
JF - Stroke (00392499)
JA - STROKE
VL - 38
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The Food and Drug Administration has established requirements for protecting the public health by assuring the safety and effectiveness of a variety of medical products including drugs, devices, and biological products, and for promoting public health by expediting the approval of treatments that are safe and effective. The Center for Devices and Radiological Health is the center within the agency that is responsible for pre- and postmarket regulation of medical devices. In this article, we review current regulation of medical devices, research and development programs, pre- and postmarket perspectives, and future considerations of medical devices, particularly as they relate to devices targeting acute ischemic stroke as an example of the process. We also review the Center for Devices and Radiological Health's historical perspective of acute ischemic stroke trials and clinical trial design considerations used in prior studies that have led to US market clearance as they are related to currently marketed devices indicated for acute ischemic stroke.
SN - 0039-2499
AD - Division of General, Restorative, and Neurological Devices, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA
U2 - PMID: 17478744.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105963654&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Maryna C. Eichelberger
T1 - The Cotton Rat as a Model to Study Influenza Pathogenesis and Immunity.
JO - Viral Immunology
JF - Viral Immunology
Y1 - 2007/06//
VL - 20
IS - 2
M3 - Article
SP - 243
EP - 249
SN - 08828245
AB - Influenza viruses continue to cause significant morbidity and mortality worldwide. With the threat of the emergence of a pandemic influenza strain, there is an urgency to develop new vaccine strategies that offer broad protection. The rational basis for the design of such vaccines comes from the use of animal models. Cotton rats are a helpful tool to study influenza disease pathogenesis and immunity because adaptation of human influenza strains is not required for virus replication in the lower respiratory tract and subsequent disease signs. This review describes innate and adaptive responses to influenza in infected cotton rats, and points out immune mechanisms that contribute to protection against disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Viral Immunology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COTTON rats
KW - INFLUENZA
KW - COMMUNICABLE diseases
KW - IMMUNITY
N1 - Accession Number: 25594851; Maryna C. Eichelberger 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.; Source Info: Jun2007, Vol. 20 Issue 2, p243; Subject Term: COTTON rats; Subject Term: INFLUENZA; Subject Term: COMMUNICABLE diseases; Subject Term: IMMUNITY; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25594851&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-11461-001
AN - 2007-11461-001
AU - del Vecchio, Paolo
AU - Fricks, Larry
T1 - Guest editorial.
T3 - Mental Health Recovery and System Transformation
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2007///Sum 2007
VL - 31
IS - 1
SP - 7
EP - 8
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
N1 - Accession Number: 2007-11461-001. Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: del Vecchio, Paolo; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20070924. Correction Date: 20150803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Initiative; Mental Health; Mental Health Services; Recovery (Disorders). Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 2. Issue Publication Date: Sum 2007.
AB - This issue focuses on mental health recovery and includes a series of articles based on papers that were commissioned for the December 2005 National Consensus Conference on Mental Health Recovery convened by the Center for Mental Health Services within the Substance Abuse and Mental Health Services Administration. In addition, related articles in this issue contribute to recently developed recovery-oriented initiatives. Recovery is not just a uniquely American movement, it is rooted in some fundamental American ideals- the right to life, liberty and the pursuit of happiness. Therefore, one should celebrate the promise of recovery and rededicate to striving to promote it universally. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health recovery
KW - mental health services
KW - initiatives
KW - American movement
KW - 2007
KW - Initiative
KW - Mental Health
KW - Mental Health Services
KW - Recovery (Disorders)
KW - 2007
DO - 10.2975/31.1.2007.7.8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11461-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16762-005
AN - 2007-16762-005
AU - Cook, Judith A.
AU - Ruggiero, Karen
AU - Shore, Sam
AU - Daggett, Pamela
AU - Butler, Sarah B.
T1 - Public-academic collaboration in the application of evidence-based practice in Texas mental health system redesign.
T3 - Community mental health collaboratives from Michigan to China
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2007///Sum 2007
VL - 36
IS - 2
SP - 36
EP - 49
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2007-16762-005. Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Other Publishers: Taylor & Francis. Release Date: 20080107. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evidence Based Practice; Family Members; Mental Health Services; Psychosocial Rehabilitation. Minor Descriptor: Authority; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 14. Issue Publication Date: Sum 2007.
AB - This article describes a public-academic collaboration between a state university research center and the Texas state mental health authority to design and evaluate a service package of psychosocial rehabilitation interventions. The project used a combination of evidence-based practice and community consensus as a tool for system change. The story of this effort and the new system that resulted is told through interviews with consumers, family members, and other advocates involved in the process, along with data from the state's management information system and reports prepared for the federal Mental Health Block Grant's Uniform Reporting System. Lessons learned about university-community partnerships are discussed in light of the current emphasis on public mental health system transformation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public academic collaboration
KW - evidence based practice
KW - mental health system redesign
KW - psychosocial rehabilitation interventions
KW - family members
KW - 2007
KW - Evidence Based Practice
KW - Family Members
KW - Mental Health Services
KW - Psychosocial Rehabilitation
KW - Authority
KW - Mental Health
KW - 2007
U1 - Sponsor: US Department of Education, National Institute on Disability and Rehabilitation Research, US. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services. Grant: Cooperative Agreement No. H133B050003. Recipients: No recipient indicated
DO - 10.2753/IMH0020-7411360204
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16762-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11461-007
AN - 2007-11461-007
AU - Schauer, Carole
AU - Everett, Anita
AU - del Vecchio, Paolo
AU - Anderson, Leigh
T1 - Promoting the value and practice of shared decision-making in mental health care.
T3 - Mental Health Recovery and System Transformation
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2007///Sum 2007
VL - 31
IS - 1
SP - 54
EP - 61
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Schauer, Carole, Center for Mental Health Services, SAMHSA, 1 Choke Cherry Road, Rm. 6-1067, Rockville, MD, US, 20857
N1 - Accession Number: 2007-11461-007. PMID: 17694716 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Schauer, Carole; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U. S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20070924. Correction Date: 20150803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Participation; Decision Making; Health Promotion; Mental Health Services; Recovery (Disorders). Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Supplemental Data: Web Sites Internet. References Available: Y. Page Count: 8. Issue Publication Date: Sum 2007.
AB - Active consumer participation is critical in contemporary mental health care and treatment planning and has been a staple of the field of psychiatric rehabilitation for the last three decades (Anthony, 1979). Providing the opportunity for consumers to chose interventions that fit personal preferences and recovery increase the likelihood that these interventions wilt enhance personal meaning, satisfaction and quality of life (Improving the Quality of Health Care for Mental and Substance Use Conditions, 2006; Cook, Terrell, & Jonikas, 2004; Anthony, Cohen, Farkas, & Gagne, 2002). Similarly, self-determination and shared decision-making are critical components of recovery. As stated in the President's New Freedom Commission on Mental Health Final Report, recovery from mental illnesses should be the expectation in mental health care with services and treatments that are consumer and family-driven. Mental health care should be planned and delivered to ensure that consumers and families with children with mental health problems receive real and meaningful choices about treatment options and providers (New Freedom Commission, 2003). The purpose of this paper is to explore the value and use of shared decision-making in health and mental health care, briefly examine the advantages and disadvantages of shared decision making and propose next steps in advancing use of shared decision-making in mental health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - shared decision making
KW - mental health care
KW - recovery
KW - consumer direction
KW - 2007
KW - Client Participation
KW - Decision Making
KW - Health Promotion
KW - Mental Health Services
KW - Recovery (Disorders)
KW - 2007
DO - 10.2975/31.1.2007.54.61
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11461-007&site=ehost-live&scope=site
UR - carole.schauer@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06465-009
AN - 2007-06465-009
AU - Cook, Judith A.
AU - Grey, Dennis D.
AU - Burke-Miller, Jane K.
AU - Cohen, Mardge H.
AU - Vlahov, David
AU - Kapadia, Farzana
AU - Wilson, Tracey E.
AU - Cook, Robert
AU - Schwartz, Rebecca M.
AU - Golub, Elizabeth T.
AU - Anastos, Kathryn
AU - Ponath, Claudia
AU - Goparaju, Lakshmi
AU - Levine, Alexandra M.
T1 - Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2007/06//
VL - 89
IS - 1
SP - 74
EP - 81
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Cook, Judith A., Center on Mental Health Services Research and Policy, Department of Psychiatry M/C 912, University of Illinois at Chicago, 1601 W. Taylor Street M/C 912, Chicago, IL, US, 60612
N1 - Accession Number: 2007-06465-009. PMID: 17291696 Partial author list: First Author & Affiliation: Cook, Judith A.; Center on Mental Health Services Research and Policy, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, US. Release Date: 20070514. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antiviral Drugs; Drug Therapy; Drug Usage; HIV; Major Depression. Minor Descriptor: Human Females; Symptoms. Classification: Immunological Disorders (3291); Medical Treatment of Physical Illness (3363). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2007.
AB - Background: We examined the interaction of illicit drug use and depressive symptoms, and how they affect the subsequent likelihood of highly active antiretroviral therapy (HAART) use among women with HIV/AIDS. Methods: Subjects included 1710 HIV-positive women recruited from six sites in the U.S. including Brooklyn, Bronx, Chicago, Los Angeles, San Francisco/Bay Area, and Washington, DC. Cases of probable depression were identified using depressive symptom scores on the Center for Epidemiologic Studies Depression Scale. Crack, cocaine, heroin, and amphetamine use were self-reported at 6-month time intervals. We conducted multivariate random logistic regression analysis of data collected during 16 waves of semiannual interviews conducted from April 1996 through March 2004. Results: We found an interaction effect between illicit drug use and depression that acted to suppress subsequent HAART use, controlling for virologic and immunologic indicators, socio-demographic variables, time, and study site. Conclusions: This is the first study to document the interactive effects of drug use and depressive symptoms on reduced likelihood of HAART use in a national cohort of women. Since evidence-based behavioral health and antiretroviral therapies for each of these three conditions are now available, comprehensive HIV treatment is an achievable public health goal. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depressive symptoms
KW - highly active antiretroviral therapy
KW - illicit drug use
KW - HIV positive women
KW - 2007
KW - Antiviral Drugs
KW - Drug Therapy
KW - Drug Usage
KW - HIV
KW - Major Depression
KW - Human Females
KW - Symptoms
KW - 2007
U1 - Sponsor: National Institute on Drug Abuse, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Allergy and Infectious Diseases, US. Grant: U01-AI-35004; UO1-AI- 31834; UO1-AI-34994; UO1-AI-34989; UO1-AI-34993; UO1-AI-42590. Other Details: Women's Interagency HIV Study is funded with supplemental funding from the National Cancer Institute, and the National Institute on Drug Abuse. Recipients: No recipient indicated
U1 - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Grant: UO1-HD-32632. Recipients: No recipient indicated
U1 - Sponsor: National Center for Research Resources, US. Grant: MO1-RR- 00071; MO1-RR-00079; MO1-RR-00083. Recipients: No recipient indicated
DO - 10.1016/j.drugalcdep.2006.12.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06465-009&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06682-001
AN - 2007-06682-001
AU - Smith, Derek R.
AU - Leggat, Peter A.
T1 - Tobacco smoking habits among a complete cross-section of Australian nursing students.
JF - Nursing & Health Sciences
JO - Nursing & Health Sciences
JA - Nurs Health Sci
Y1 - 2007/06//
VL - 9
IS - 2
SP - 82
EP - 89
CY - United Kingdom
PB - Blackwell Publishing
SN - 1441-0745
SN - 1442-2018
AD - Smith, Derek R., International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2007-06682-001. PMID: 17470180 Partial author list: First Author & Affiliation: Smith, Derek R.; National Institute of Occupational Safety and Health, Kawasaki, Japan. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070709. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Habits; Nursing Students; Tobacco Smoking; Undergraduate Education. Classification: Professional Psychological & Health Personnel Issues (3400); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2007.
AB - This study was undertaken as a complete cross-sectional survey of tobacco smoking habits among 270 undergraduate students at an Australian nursing school (response rate: 84.6%). An anonymous, self-reporting questionnaire survey was used to gather the data. The overall prevalence of current smoking was 15.9%, with a further 8.5% being ex-smokers. The nursing students consumed an average of 11.5 cigarettes per day, they began smoking at 20.8 years of age, and had an average smoking duration of 7.2 years. The students who had previously worked as a nurse were twice as likely to be current smokers. This study suggests that although tobacco smoking remains fairly common among Australian nursing students, its prevalence and distribution vary according to the individual demographics of the group under study. Future researchers will need to consider the changing demographic base from which the new generation of nursing students are drawn. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tobacco smoking habits
KW - Australian nursing students
KW - undergraduate students
KW - 2007
KW - Habits
KW - Nursing Students
KW - Tobacco Smoking
KW - Undergraduate Education
KW - 2007
DO - 10.1111/j.1442-2018.2007.00306.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06682-001&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-8202-2523
UR - smith@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10478-001
AN - 2007-10478-001
AU - Tobias, Carol
AU - Cunningham, William E.
AU - Cunningham, Chinazo O.
AU - Pounds, Moses B.
T1 - Making the connection: The importance of engagement and retention in HIV medical care.
JF - AIDS Patient Care and STDs
JO - AIDS Patient Care and STDs
JA - AIDS Patient Care STDS
Y1 - 2007/06//
VL - 21
IS - Suppl1
SP - S3
EP - S8
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
SN - 1557-7449
AD - Tobias, Carol, Health and Disability Working Group, 374 Congress Street, Suite 502, Boston, MA, US, 02210
N1 - Accession Number: 2007-10478-001. Partial author list: First Author & Affiliation: Tobias, Carol; Health and Disability Working Group, Boston University School of Public Health, Boston, MA, US. Release Date: 20080121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cunningham, Chinazo O. Major Descriptor: Health Care Services; Health Care Utilization; HIV; Health Care Policy; Treatment Barriers. Minor Descriptor: Treatment Compliance. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2007.
AB - Despite the availability and proven efficacy of medical treatment, many individuals living with HIV in the United States today are not engaged in regular HIV medical care or receiving antiretroviral medications. This journal supplement highlights results of a national 5-year multisite Outreach Initiative, funded by the Health Resources and Services Administration (HRSA) in 2001 to 'engage people in HIV care, turn sporadic users of care into regular users, and promote retention in care.' The introductory paper for the supplement provides background information on the characteristics of individuals who are not engaged in regular HIV care, the barriers they face, intervention options, and the public policy implications of this issue. Interventions to engage and retain underserved populations living with HIV in medical care are essential to ensure access to medical care and to reduce disparities in health outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV medical care
KW - treatment engagement
KW - treatment retention
KW - public policy
KW - medical care utilization
KW - barriers to care
KW - HIV positive individuals
KW - 2007
KW - Health Care Services
KW - Health Care Utilization
KW - HIV
KW - Health Care Policy
KW - Treatment Barriers
KW - Treatment Compliance
KW - 2007
U1 - Sponsor: Health Resources and Services Administration, HIV/AIDS Bureau, Special Projects of National Significance, US. Grant: H97HA00191-05-07. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Grant: H97HA00203. Recipients: Cunningham, Chinazo O.
U1 - Sponsor: National Institute of Mental Health, US. Grant: R-01 MH69087. Recipients: No recipient indicated
U1 - Sponsor: UCLA, Drew Project Export. Other Details: Drew Project Export. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Center on Minority Health and Health Disparities, US. Grant: P20-MD00148-01. Recipients: No recipient indicated
U1 - Sponsor: UCLA, CHIME, RCMAR. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute on Aging, US. Grant: AG-02-004. Recipients: No recipient indicated
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: P01 HS10858-04. Recipients: Shapiro, M.F. (Prin Inv)
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10478-001&site=ehost-live&scope=site
UR - tcarol@bu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-03717-002
AN - 2008-03717-002
AU - Pompili, Maurizio
AU - Innamorati, Marco
AU - Mosticoni, Stefano
AU - Lester, David
AU - Del Casale, Antonio
AU - Ardenghi, Gloria
AU - Volterri, Susanna
AU - Angelone, Massimiliano
AU - Comazzetto, Claudia
AU - Gentili, Federica
AU - Erbuto, Denise
AU - Verrastro, Rosanna
AU - Manfredi, Giovanni
AU - Giupponi, Giancarlo
AU - Girardi, Paolo
AU - Tatarelli, Roberto
AU - Grispini, Alessandro
T1 - Suicide attempts in major affective disorders.
JF - Clinical Neuropsychiatry: Journal of Treatment Evaluation
JO - Clinical Neuropsychiatry: Journal of Treatment Evaluation
JA - Clin Neuropsychiatry
Y1 - 2007/06//
VL - 4
IS - 3
SP - 106
EP - 110
CY - Italy
PB - Giovanni Fioriti Editore
SN - 1724-4935
SN - 2385-0787
AD - Pompili, Maurizio, Department of Psychiatry, Ospedale Sant'Andrea, Via di Grottarossa, 1035, 00189, Roma, Italy
N1 - Accession Number: 2008-03717-002. Partial author list: First Author & Affiliation: Pompili, Maurizio; Department of Psychiatry, Sant' Andrea Hospital, 'La Sapienza' University of Rome, Rome, Italy. Release Date: 20080728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Attempted Suicide; Suffering; Suicide. Minor Descriptor: Patients. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jun, 2007.
AB - Object: The aim of this study was to investigate variables associated with suicide attempts among patients suffering from major affective disorders. Methods: We retrospectively evaluated 106 patients diagnosed with major affective disorders. 53 patients with at least one suicide attempt were matched on a group basis for age, sex and diagnosis with 53 patients who had never attempted suicide. Results: In the bivariate comparisons, suicidal patients were more likely to have been treated with antipsychotic and anxiolytic drugs (OR: 4.50; 95% CI: 1.55/13.06), and less likely to be married (OR: .16; 95% CI: .07/.36), have comorbid physical illnesses (OR: .29; 95% CI: .12/.67) and have been treated with antidepressants (OR: .14; 95% CI: .04/.47). Conclusions: Our results support previously reported findings in the literature that marital status, and treatment regimen may influence suicide risk. Limitations: The study findings may not generalize to other samples, settings, and treatment programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide attempts
KW - major affective disorders
KW - patient suffering
KW - 2007
KW - Affective Disorders
KW - Attempted Suicide
KW - Suffering
KW - Suicide
KW - Patients
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03717-002&site=ehost-live&scope=site
UR - maurizio.pompili@uniroma1.it
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09905-010
AN - 2007-09905-010
AU - Joiner, Thomas
AU - Kalafat, John
AU - Draper, John
AU - Stokes, Heather
AU - Knudson, Marshall
AU - Berman, Alan L.
AU - McKeon, Richard
T1 - Establishing standards for the assessment of suicide risk among callers to the National Suicide Prevention Lifeline.
JF - Suicide and Life-Threatening Behavior
JO - Suicide and Life-Threatening Behavior
JA - Suicide Life Threat Behav
Y1 - 2007/06//
VL - 37
IS - 3
SP - 353
EP - 365
CY - US
PB - Guilford Publications
SN - 0363-0234
SN - 1943-278X
AD - Joiner, Thomas, FSU Psychology, Tallahassee, FL, US, 32306-1270
N1 - Accession Number: 2007-09905-010. PMID: 17579546 Other Journal Title: Life-Threatening Behavior; Suicide. Partial author list: First Author & Affiliation: Joiner, Thomas; Florida State University, Tallahassee, FL, US. Other Publishers: Behavioral Publications; Human Sciences Press, Inc.; Wiley-Blackwell Publishing Ltd. Release Date: 20070917. Correction Date: 20130610. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Crisis Intervention; Hot Line Services; Professional Standards; Suicide Prevention; Risk Assessment. Minor Descriptor: Drug Abuse; Mental Health Services; Suicide. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Jun, 2007.
AB - The National Suicide Prevention Lifeline was launched in January 2005. Lifeline, supported by a federal grant from the Substance Abuse and Mental Health Services Administration, consists of a network of more than 120 crisis centers located in communities across the country that are committed to suicide prevention. Lifeline's Certification and Training Subcommittee conducted an extensive review of research and field practices that yielded the Lifeline's Suicide Risk Assessment Standards. The authors of the current paper provide the background on the need for these standards; describe the process that produced them; summarize the research and rationale supporting the standards; review how these standard assessment principles and their subcomponents can be weighted in relation to one another so as to effectively guide crisis hotline workers in their everyday assessments of callers to Lifeline; and discuss the implementation process that will be provided by Lifeline. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - establishing standards
KW - assessment of suicide risk factors
KW - National Suicide Prevention Lifeline
KW - crisis intervention
KW - substance abuse
KW - mental health services
KW - 2007
KW - Crisis Intervention
KW - Hot Line Services
KW - Professional Standards
KW - Suicide Prevention
KW - Risk Assessment
KW - Drug Abuse
KW - Mental Health Services
KW - Suicide
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Other Details: Link2Health Solutions, Inc.. Recipients: No recipient indicated
DO - 10.1521/suli.2007.37.3.353
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09905-010&site=ehost-live&scope=site
UR - joiner@psy.fsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10473-005
AN - 2007-10473-005
AU - Tobias, Carol R.
AU - Cunningham, William
AU - Cabral, Howard D.
AU - Cunningham, Chinazo O.
AU - Eldred, Lois
AU - Naar-King, Sylvie
AU - Bradford, Judith
AU - Sohler, Nancy L.
AU - Wong, Mitchell D.
AU - Drainoni, Mari-Lynn
T1 - Living with HIV but without medical care: Barriers to engagement.
JF - AIDS Patient Care and STDs
JO - AIDS Patient Care and STDs
JA - AIDS Patient Care STDS
Y1 - 2007/06//
VL - 21
IS - 6
SP - 426
EP - 434
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
SN - 1557-7449
AD - Tobias, Carol R., Health and Disability Working Group, Boston University School of Public Health, 374 Congress Street, Suite 503, Boston, MA, US, 02210
N1 - Accession Number: 2007-10473-005. PMID: 17594252 Partial author list: First Author & Affiliation: Tobias, Carol R.; Boston University School of Public Health, Boston, MA, US. Release Date: 20080121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; HIV; Treatment Barriers. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: SF-12; Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jun, 2007.
AB - This cross-sectional study examined factors associated with the receipt of HIV medical care among people who know their HIV status and are not newly diagnosed with HIV. Interviews were conducted with 1133 HIV-positive individuals between October 2003 and July 2005 who enrolled in 1 of 10 outreach programs across the country. The sample was predominantly non-white (86%), male (59%), and unstably housed (61%), with a past history of cocaine use (68%). Twelve percent had received no HIV medical care in the 6 months prior to the interview. Those with no care were similar to those who received some HIV care in sociodemographic characteristics, but in multivariate analysis were less likely to have a case manager (p < 0.001) or use mental health services (p < .001), had lower mental health status scores (p < 0.05), were more likely to be active drug users (p < 0.01), had greater unmet support service needs (p < 0.05) and reported that health beliefs were a barrier to care (p < 0.001). Interventions to engage people in HIV medical care need to address barriers to care through linkages with mental health, substance abuse treatment and support services, and address the health beliefs that deter people from seeking care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV status
KW - medical care
KW - treatment barriers
KW - 2007
KW - Health Care Services
KW - HIV
KW - Treatment Barriers
KW - 2007
U1 - Sponsor: Health Resources and Services Administration, HIV/AIDS Bureau. Grant: H97HA00191. Other Details: Projects of National Significance. Recipients: No recipient indicated
DO - 10.1089/apc.2006.0138
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10473-005&site=ehost-live&scope=site
UR - tcarol@bu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08360-008
AN - 2007-08360-008
AU - Hsiao, Hongwei
AU - Whitestone, Jennifer
AU - Kau, Tsui-Ying
T1 - Evaluation of fall arrest harness sizing schemes.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 2007/06//
VL - 49
IS - 3
SP - 447
EP - 464
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
AD - Hsiao, Hongwei, Protective Technology Branch, Division of Safety Research, NIOSH, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2007-08360-008. PMID: 17552309 Partial author list: First Author & Affiliation: Hsiao, Hongwei; National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Sage Publications. Release Date: 20070806. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Falls; Safety Devices; Working Conditions. Minor Descriptor: Failure. Classification: Human Factors Engineering (4010); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: Jun, 2007.
AB - Objective: This paper evaluated harness sizing schemes and anthropometric criteria for harness design applications. Background: Updated harness sizing systems are needed to accommodate diverse populations in the current workforce. Method: Three-dimensional torso scan data and human-harness interfaces from 108 women and 108 men were digitally captured. Abounding box approach was employed to quantify the effect of torso shape and size on fall harness fit. Results: A logistic regression model with eight equations was developed and tested to classify more than 96% of participants to the best-fitting size. Conclusion: Study outcomes suggested an alternative system of two sizes for women and three sizes for men over the current four-size unisex system. In addition, thigh strap angle and back D ring location could be utilized along with current harness static fit test criteria to further enhance postfall harness fit predictions. Application: This research could help reduce the risk of worker injury resulting from poor fit, improper size selection, or failure to don the harness properly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fall harness schemes
KW - anthropometric criteria
KW - harness design applications
KW - 2007
KW - Falls
KW - Safety Devices
KW - Working Conditions
KW - Failure
KW - 2007
DO - 10.1518/001872007X200094
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08360-008&site=ehost-live&scope=site
UR - hhsiao@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08023-006
AN - 2007-08023-006
AU - Bell, Stephanie G.
AU - Newcomer, Susan F.
AU - Bachrach, Christine
AU - Borawski, Elaine
AU - Jemmott, John B. III
AU - Morrison, Diane
AU - Stanton, Bonita
AU - Tortolero, Susan
AU - Zimmerman, Richard
T1 - Challenges in replicating interventions.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2007/06//
VL - 40
IS - 6
SP - 514
EP - 520
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Newcomer, Susan F., NICHD, Building 61E, Room 8B7G, Bethesda, MD, US, 20892
N1 - Accession Number: 2007-08023-006. PMID: 17531757 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Bell, Stephanie G.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20070625. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Borawski, Elaine. Major Descriptor: Health; Insight; Intervention; Risk Factors. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2007.
AB - Purpose: To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. Methods: Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. Results: Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention 'to scale' are not discussed. Conclusions: Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk behavior interventions
KW - insights
KW - health
KW - 2007
KW - Health
KW - Insight
KW - Intervention
KW - Risk Factors
KW - 2007
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01-HD038456. Recipients: Borawski, Elaine
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01-HD039109. Recipients: Jemmott, John B. III
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01-HD038420. Recipients: Morrison, Diane
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01-MH061761. Recipients: Stanton, Bonita
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01- HD038457. Recipients: Tortolero, Susan
U1 - Sponsor: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Mental Health. Grant: R01-MH061187. Recipients: Zimmerman, Richard
DO - 10.1016/j.jadohealth.2006.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08023-006&site=ehost-live&scope=site
UR - newcomes@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08224-012
AN - 2007-08224-012
AU - Moritsugu, Kenneth P.
T1 - The 2006 report of the surgeon general: The Health Consequences of Involuntary Exposure to Tobacco Smoke.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2007/06//
VL - 32
IS - 6
SP - 542
EP - 543
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Moritsugu, Kenneth P., Health Communications Branch, CDC Office on Smoking and Health, 4770 Buford Highway, NE, MS-K50, Atlanta, GA, US, 30341-3717
N1 - Accession Number: 2007-08224-012. PMID: 17533072 Partial author list: First Author & Affiliation: Moritsugu, Kenneth P.; Office of the Acting U.S. Surgeon General, U.S. Public Health Service, Washington, DC, US. Release Date: 20070813. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hazards; Health; Symptoms; Tobacco Smoking. Minor Descriptor: Consequence. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jun, 2007.
AB - The 2006 Surgeon General's report, The Health Consequences of Involuntary Exposure to Tobacco Smoke, documents beyond any doubt that secondhand smoke harms people's health, as it reaffirms, updates, and expands on the conclusions of the 1986 report. This report is based on a comprehensive review of the scientific literature and a systematic evaluation of the evidence for causality. The implications of this report are straightforward, given that there is a clear scientific consensus: Secondhand smoke is a serious health hazard, not just an annoyance. Separate 'no-smoking' sections, open windows, or ventilation systems do not protect nonsmokers from secondhand smoke exposure. Because there is no risk-free level, people should avoid all exposure to secondhand smoke. This is especially true for members of certain populations who are more susceptible to the health effects of secondhand smoke, including infants and children, pregnant women, older persons, and those with pre-existing respiratory conditions or heart disease. While much progress has been made, much more needs to be done to reduce exposure to secondhand smoke and protect people from its adverse health effects. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - surgeon general
KW - health consequences
KW - involuntary exposure
KW - tobacco smoke
KW - 2007
KW - Hazards
KW - Health
KW - Symptoms
KW - Tobacco Smoking
KW - Consequence
KW - 2007
DO - 10.1016/j.amepre.2007.02.026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08224-012&site=ehost-live&scope=site
UR - sbabb@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08023-013
AN - 2007-08023-013
AU - Pedersen, Court
AU - Petaja, Tiina
AU - Strauss, Gitte
AU - Rumke, Hans C.
AU - Poder, Airi
AU - Richardus, Jan Hendrik
AU - Spiessens, Bart
AU - Descamps, Dominique
AU - Hardt, Karin
AU - Lehtinen, Matti
AU - Dubin, Gary
T1 - Immunization of early adolescent females with human papillomavirus Type 16 and 18 L1 virus-like particle vaccine containing AS04 adjuvant.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2007/06//
VL - 40
IS - 6
SP - 564
EP - 571
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Lehtinen, Matti, School of Public Health, University of Tampere, 33014, Tampere, Finland
N1 - Accession Number: 2007-08023-013. PMID: 17531764 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Pedersen, Court; Odense University Hospital, Odense, Denmark. Institutional Authors: HPV Vaccine Adolescent Study Investigators Network. Release Date: 20070625. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antibodies; Human Females; Immunization; Neoplasms; Prevention. Minor Descriptor: Human Papillomavirus. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: Denmark; Estonia; Finland; Greece. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2007.
AB - Purpose: In female individuals 15-25-years of age, the AS04-containing human papillomavirus (HPV)-16/18 vaccine is highly immunogenic and provides up to 100% protection against HPV-16/18 persistent infection and associated cervical lesions up to 4.5 years. Optimal cervical cancer prevention will require prophylactic vaccination against oncogenic HPV 16 and 18 before the onset of sexual activity in early adolescent girls. To establish the feasibility of vaccination in girls 10-14 years of age, we compared the immunogenicity and safety in early adolescent female individuals to those 15-25 years in whom vaccine efficacy has been demonstrated. Methods: We enrolled 773 female participants aged 10-14 years and 15-25 years to receive the HPV-16/18 L1 VLP AS04 vaccine, which was administered at months 0, 1, and 6. Serum samples were collected at months 0 and 7; antibodies to HPV 16 and 18 VLPs were measured by enzyme-linked immunosorbent assay. Vaccine safety was assessed at 7 or 30 days after each dose; serious adverse events were recorded during the entire study period. Results: Both age groups achieved 100% seroconversion for HPV 16 and 18. Participants in the group aged 10-14 years were not only noninferior to those 15-25 years in terms of HPV 16 and 18 seroconversion rates but also had approximately twice as high geometric mean titers. The vaccine was generally safe and well tolerated. Conclusions: These findings suggest that HPV vaccination during early adolescence is generally safe, well tolerated, and highly immunogenic. The observed higher antibody titers in the group 10-14 years of age are likely to result in longer antibody persistence. Overall, these data support the implementation of prophylactic HPV vaccination in this age group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - immunization
KW - early adolescent females
KW - human papillomavirus
KW - AS04 adjuvant
KW - cervical cancer prevention
KW - 2007
KW - Antibodies
KW - Human Females
KW - Immunization
KW - Neoplasms
KW - Prevention
KW - Human Papillomavirus
KW - 2007
U1 - Sponsor: GlaxoSmithKline Biologicals, Belgium. Grant: 580299/012. Recipients: No recipient indicated
DO - 10.1016/j.jadohealth.2007.02.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08023-013&site=ehost-live&scope=site
UR - matti.lehtinen@uta.fi
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11253-011
AN - 2007-11253-011
AU - Wheeler, Matthew W.
AU - Bailer, A. John
T1 - Properties of model-averaged BMDLs: A study of model averaging in dichotomous response risk estimation.
T3 - Special Issue on Terrorism
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2007/06//
VL - 27
IS - 3
SP - 659
EP - 670
CY - United Kingdom
PB - Blackwell Publishing
SN - 0272-4332
SN - 1539-6924
AD - Wheeler, Matthew W., National Institute for Occupational Safety and Health, Risk Evaluation Branch, MS C-15, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-11253-011. PMID: 17640214 Partial author list: First Author & Affiliation: Wheeler, Matthew W.; National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070924. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Uncertainty; Risk Assessment. Minor Descriptor: Simulation. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Jun, 2007.
AB - Model averaging (MA) has been proposed as a method of accounting for model uncertainty in benchmark dose (BMD) estimation. The technique has been used to average BMD dose estimates derived from dichotomous dose-response experiments, microbial dose-response experiments, as well as observational epidemiological studies. While MA is a promising tool for the risk assessor, a previous study suggested that the simple strategy of averaging individual models' BMD lower limits did not yield interval estimators that met nominal coverage levels in certain situations, and this performance was very sensitive to the underlying model space chosen. We present a different, more computationally intensive, approach in which the BMD is estimated using the average dose-response model and the corresponding benchmark dose lower bound (BMDL) is computed by bootstrapping. This method is illustrated with TiO₂ dose-response rat lung cancer data, and then systematically studied through an extensive Monte Carlo simulation. The results of this study suggest that the MA-BMD, estimated using this technique, performs better, in terms of bias and coverage, than the previous MA methodology. Further, the MA-BMDL achieves nominal coverage in most cases, and is superior to picking the 'best fitting model' when estimating the benchmark dose. Although these results show utility of MA for benchmark dose risk estimation, they continue to highlight the importance of choosing an adequate model space as well as proper model fit diagnostics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - properties
KW - dichotomous response
KW - risk estimation
KW - model uncertainty
KW - benchmark dose
KW - 2007
KW - Epidemiology
KW - Uncertainty
KW - Risk Assessment
KW - Simulation
KW - 2007
DO - 10.1111/j.1539-6924.2007.00920.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11253-011&site=ehost-live&scope=site
UR - MWheeler@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09339-028
AN - 2007-09339-028
AU - Fisher, William H.
T1 - Review of Better but not well: Mental health policy in the United States since 1950.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/06//
VL - 58
IS - 6
SP - 881
EP - 881
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2007-09339-028. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Fisher, William H.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20070709. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Review-Book. Language: English. Major Descriptor: Disabilities; Government Policy Making; Mental Disorders; Mental Health; Psychiatry. Classification: Psychological Disorders (3210); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Frank, Richard G.; Glied, Sherry A. Better but not well: Mental health policy in the United States since 1950=Baltimore, Johns Hopkins University Press, 208 pages, $21.95; 2006. References Available: Y. Page Count: 1. Issue Publication Date: Jun, 2007.
AB - Reviews the book, Better but not well: Mental health policy in the United States since 1950 by Richard G. Frank and Sherry A. Glied (2006). As the book's title suggests, the authors argue that the status of persons with psychiatric disabilities has improved significantly in the past 50 years in a host of different dimensions but still is not where it could or should be. In the final chapter the authors suggest reforms for further improving the lives of persons with psychiatric disorders. Their observations are responsive to those of Rosalynn Carter, who, in her foreword to the book, argues that progress has been attempted but in some cases thwarted politically and that much reform remains to be accomplished. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health policy
KW - psychiatric disorders
KW - 2007
KW - Disabilities
KW - Government Policy Making
KW - Mental Disorders
KW - Mental Health
KW - Psychiatry
KW - 2007
U2 - Frank, Richard G.; Glied, Sherry A. (2006); Better but not well: Mental health policy in the United States since 1950; Baltimore, Johns Hopkins University Press, 208 pages, $21.95
DO - 10.1176/appi.ps.58.6.881
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09339-028&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19188-015
AN - 2007-19188-015
AU - Zayas, Luis H.
AU - Cabassa, Leopoldo J.
AU - Perez, M. Carmela
AU - Cavazos-Rehg, Patricia A.
T1 - Using interpreters in diagnostic research and practice: Pilot results and recommendations.
JF - The Journal of Clinical Psychiatry
JO - The Journal of Clinical Psychiatry
JA - J Clin Psychiatry
Y1 - 2007/06//
VL - 68
IS - 6
SP - 924
EP - 928
CY - US
PB - Physicians Postgraduate Press
SN - 0160-6689
AD - Zayas, Luis H., Washington University in St. Louis, Campus Box 1196, One Brookings Dr., St. Louis, MO, US, 63130-4899
N1 - Accession Number: 2007-19188-015. PMID: 17592918 Other Journal Title: Diseases of the Nervous System. Partial author list: First Author & Affiliation: Zayas, Luis H.; George Warren Brown School of Social Work and the Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, US. Release Date: 20080303. Correction Date: 20160919. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Foreign Language Translation; Outpatients; Psychodiagnosis; Psychodiagnostic Interview; Latinos/Latinas. Minor Descriptor: Psychiatric Clinics; Urban Environments; Interpreters. Classification: Community & Social Services (3373); Linguistics & Language & Speech (2720). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jun, 2007.
AB - Objective: This pilot study examined the impact and role of interpreters in videotaped and some live diagnostic interviews of Hispanic outpatients in an urban psychiatric service. Method: The study, conducted from June 2002 to February 2004, included 98 bilingual or Spanish-speaking monolingual adult Hispanic outpatients who participated in live or videotaped diagnostic interviews with English-speaking, non-Hispanic (N = 33) or Hispanic (N = 16) clinicians. Interpreters provided assistance to patients and to non-Hispanic clinicians in 71 cases. After completing live interviews or watching videotaped interviews with interpreter assistance, clinicians independently filled out questionnaires asking for diagnoses and other information (questions about the clinical encounter and rating of symptom severity). Results: Clinicians reported high confidence in their assessments because interpreters provided unbiased, accurate information. Without interpreters, clinicians reported that patient diagnoses and functioning would have been assessed as less severe or the same. Interpreters helped patients with limited English navigate mostly videotaped interviews and respond to clinician queries. Interpreters brokered cultural expressions and colloquialism, distinguished easily misunderstood words and concepts, and were challenged by patients with cognitive deficits and thought disorders. Conclusions: Findings point to functions, process, and logistics of interpretation, including reaching for linguistic and conceptual fidelity and acting as unobtrusive, disciplined participants to maintain diagnostic accuracy. Recommendations for assuring useful research-quality data are applicable to diagnostic practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - interpreters
KW - diagnostic research
KW - diagnostic interviews
KW - Hispanic outpatients
KW - urban psychiatric service
KW - 2007
KW - Foreign Language Translation
KW - Outpatients
KW - Psychodiagnosis
KW - Psychodiagnostic Interview
KW - Latinos/Latinas
KW - Psychiatric Clinics
KW - Urban Environments
KW - Interpreters
KW - 2007
U1 - Sponsor: National Institute of Mental Health. Grant: R21 MH06592J. Recipients: No recipient indicated
DO - 10.4088/JCP.v68n0615
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19188-015&site=ehost-live&scope=site
UR - lzayas@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07735-012
AN - 2007-07735-012
AU - Kaida, Kosuke
AU - Åkerstedt, Torbjörn
AU - Kecklund, Göran
AU - Nilsson, Jens P.
AU - Axelsson, John
T1 - The effects of asking for verbal ratings of sleepiness on sleepiness and its masking effects on performance.
JF - Clinical Neurophysiology
JO - Clinical Neurophysiology
JA - Clin Neurophysiol
Y1 - 2007/06//
VL - 118
IS - 6
SP - 1324
EP - 1331
CY - Netherlands
PB - Elsevier Science
SN - 1388-2457
AD - Kaida, Kosuke, National Institute of Occupational Safety and Health (JNIOSH), 6-21-1, Nagao, Tamaku, Kawasaki, Kanagawa, Japan, 214-8585
N1 - Accession Number: 2007-07735-012. PMID: 17466585 Other Journal Title: Electroencephalography & Clinical Neurophysiology. Partial author list: First Author & Affiliation: Kaida, Kosuke; National Institute of Occupational Safety and Health (JNIOSH), Kanagawa, Japan. Release Date: 20070813. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Eyeblink Reflex; Heart Rate; Masking; Sleep Onset; Sleepiness. Minor Descriptor: Electroencephalography. Classification: Physiological Processes (2540). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Karolinska Drowsiness Test; Karolinska Sleepiness Scale; Subjective Performance Questionnaire; Mackworth Clock Test. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2007.
AB - Objective: This study investigated whether verbal rating sleepiness will itself affect sleepiness and performance. Methods: Thirteen healthy male volunteers (mean age, 26.9 years) performed two 40-min vigilance tests, one of which involved verbal ratings every 4 min using the Karolinska sleepiness scale and another of which did not involve any ratings during the test. Results: Repeated rating of sleepiness significantly reduced post-test sleepiness and improved the subjective perception of performance, and also reduced alpha power density (i.e., a physiological indicator of sleepiness). However, performance was not improved by the ratings. Conclusions: The act of rating affects subjective and EEG measures of sleepiness. Presumably this occurs through the modest stimulation involved in this act. Significance: Methodologically one should be aware of subtle effects of the rating situation on sleepiness. From a practical point of view, it would be important for safety management since subjective sleepiness and performance are easily dissociated, which might interfere with risk perception. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - verbal rating sleepiness
KW - masking effects
KW - sleepiness
KW - performance
KW - eye blink
KW - heart rate variability
KW - electroencephalography
KW - 2007
KW - Eyeblink Reflex
KW - Heart Rate
KW - Masking
KW - Sleep Onset
KW - Sleepiness
KW - Electroencephalography
KW - 2007
U1 - Sponsor: European Union. Grant: IST 507231. Other Details: Integrated project SENSATION. Recipients: No recipient indicated
DO - 10.1016/j.clinph.2007.03.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07735-012&site=ehost-live&scope=site
UR - kaida-kosuke@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-07732-013
AN - 2007-07732-013
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Ikeda, Tomoko
AU - Haratani, Takashi
AU - Hojou, Minoru
AU - Araki, Shunichi
T1 - Perceived job stress and sleep-related breathing disturbance in Japanese male workers.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2007/06//
VL - 64
IS - 12
SP - 2520
EP - 2532
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Nakata, Akinori, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-07732-013. PMID: 17433513 Partial author list: First Author & Affiliation: Nakata, Akinori; National Institute of Occupational Safety and Health, Japan. Release Date: 20080114. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Occupational Stress; Personnel; Respiration; Sleep. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Generic Job Stress Questionnaire; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jun, 2007.
AB - To examine the association of job stress with sleep-related breathing disturbance (SBD), a cross-sectional sample of 1940 males aged 17-83 (mean 45) years in 292 small and medium-sized enterprises in Japan were surveyed by means of a self-administered questionnaire. Perceived job stress was evaluated by the Japanese version of the Generic Job Stress Questionnaire developed by the US National Institute for Occupational Safety and Health, which included 13 job stress variables. Participants were divided into thirds according to their job stress scores. SBD was assessed by the question 'Have you ever felt difficulty breathing during sleep or has anyone in your family told you that you have such difficulty?' SBD was defined as presence of symptoms more than once a month. Risk of SBD through job stress was estimated using logistic regression with odds ratios (ORs) and 95% confidence intervals (CIs) as measures of association. Prevalence of study-defined SBD was 6.7%. Participants who perceived the lowest level of social support from supervisors, and highest levels of job future ambiguity, interpersonal conflict at the workplace, job dissatisfaction, variance in workload, and quantitative workload had significantly increased risk of SBD after adjusting for potential confounders. High depressive symptoms, as measured by Center for Epidemiologic Studies Depression scale scores of 16 or higher, were also significantly associated with increased SDB. Although the results should be considered preliminary because of the self-reporting and cross-sectional design, data suggest that exposure to high job stress could be a possible risk factor for developing or aggravating SBD. Results also indicate that job stress should be considered when evaluating SBD in occupational and clinical settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perceived job stress
KW - sleep related breathing disturbance
KW - male workers
KW - occupational settings
KW - 2007
KW - Occupational Stress
KW - Personnel
KW - Respiration
KW - Sleep
KW - 2007
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Participation Program. Recipients: No recipient indicated
U1 - Sponsor: Oak Ridge Institute for Science and Education. Other Details: Through an interagency agreement between the US Department of Energy and CDC. Recipients: No recipient indicated
U1 - Sponsor: Ministry of Education, Culture, Sports, Science and Technology, Japan. Grant: 16659634. Recipients: No recipient indicated
DO - 10.1016/j.socscimed.2007.03.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07732-013&site=ehost-live&scope=site
UR - araki@h.jniosh.go.jp
UR - hojou@big.or.jp
UR - haratani@h.jniosh.go.jp
UR - ikedat@ipu.ac.jp
UR - takaham@h.jniosh.go.jp
UR - nakataa-tky@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Eldred, Lois
AU - Malitz, Faye
T1 - Introduction.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2007/06/02/Jun2007 Supplement
VL - 21
M3 - Article
SP - S-1
EP - S-2
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - The article discusses the provision palliative treatment of people suffering from acute AIDS/HIV infections. The availability of highly active antiretroviral therapy (HAART) has altered the course of HIV disease. Medication adherence in HIV disease has drawn a great attention in research and practice. In order to maintain patients' long-term health, there is a need to assure that HIV acre is accessible, adaptable, culturally responsive and of the highest quality.
KW - AIDS (Disease)
KW - Palliative treatment
KW - HIV infections
KW - Highly active antiretroviral therapy
KW - Immune system
KW - HIV-positive persons
KW - Long-term care of the sick
N1 - Accession Number: 25354407; Eldred, Lois 1; Email Address: leldred1@jhmi.edu; Malitz, Faye 2; Affiliations: 1: Johns Hopkins University, Baltimore, Maryland; 2: Division of Science and Policy, Health Resources and Services Administration, HIV/AIDS Bureau, Rockville, Maryland; Issue Info: Jun2007 Supplement, Vol. 21, pS-1; Thesaurus Term: AIDS (Disease); Subject Term: Palliative treatment; Subject Term: HIV infections; Subject Term: Highly active antiretroviral therapy; Subject Term: Immune system; Subject Term: HIV-positive persons; Subject Term: Long-term care of the sick; Number of Pages: 2p; Document Type: Article
L3 - 10.1089/apc.2007.9993
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Suhong Chen
AU - Guiyuan Lv
AU - Xiaodong Zhang
AU - Xiaoyu Liu
AU - Han Zhang
AU - Yunwei Zhu
AU - Yin Wu
AU - Saiyue Liu
AU - Zhunan Ni
T1 - Anti-hypertensive effects of laiju extract in two different rat models.
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
Y1 - 2007/06/02/2007 Supplement 1
VL - 16
M3 - Article
SP - 309
EP - 312
SN - 09647058
AB - The aim of the stody was to evaluate whether laiju extract (LJE) from Semen Raphani and Flos Chrysanthemi has an anti-hypertensive effect in renal hypertensive rat (RIIR) and spontaneous hypertensive rat (SItR). LJE was prepared by extracting dried Semen Raphani and Flos Chrysanthemi with 70% ethanol. RHR and SHR models were prepared by standard methods. Forty RHRs and 40 SHRs were randomly divided into high LJE (300 mg/kg), moderate LJE (200 mg/kg), low LJE (100 mg/kg) and saline control four groups (n-10), respectively. Compared with saline control, blood pressure was significantly lowered al 6 and 5 hours in high and moderate LJE respectively in both RHR and SHR groups, However, blood pressure was significantly lowered at 2 and 3 hours in low LJE in both RHR and SHR groups, respectively. Compared with saline control, blood pressure remained significantly lower in SHR in all dosage groups with a single daily dose for 28 days of study. LJE has potential m the prevention management of hypertension. Further studies are needed to identify the active chemical constituents and mechanisms of action of LJE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Asia Pacific Journal of Clinical Nutrition is the property of Asia Pacific Journal of Clinical Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIHYPERTENSIVE agents
KW - EXTRACTS
KW - RATS
KW - DISASTER relief
KW - EVALUATION
KW - disaster relief
KW - evaluation
KW - expert system
KW - food aid
KW - monitoring
N1 - Accession Number: 25646879; Suhong Chen 1 Guiyuan Lv 2; Email Address: lv.gy@263.net Xiaodong Zhang 3 Xiaoyu Liu 2 Han Zhang 2,4 Yunwei Zhu 2 Yin Wu 2 Saiyue Liu 2 Zhunan Ni 2; Affiliation: 1: Academy of Traditional Chinese Medicine, Wenzhou Medical College, Wenzhou, China 2: Institute of Materia Medica, Zhejiang Chinese Medical University,, Hangzhou. China 3: Center for Drug Evaluation, State of Food and Drug Administration, Beijing, 4: Shanghai University of Traditional Chinese Medicine. Shanghai, China; Source Info: 2007 Supplement 1, Vol. 16, p309; Subject Term: ANTIHYPERTENSIVE agents; Subject Term: EXTRACTS; Subject Term: RATS; Subject Term: DISASTER relief; Subject Term: EVALUATION; Author-Supplied Keyword: disaster relief; Author-Supplied Keyword: evaluation; Author-Supplied Keyword: expert system; Author-Supplied Keyword: food aid; Author-Supplied Keyword: monitoring; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25646879&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Aimin
AU - Piccardo, Pedro
AU - Barmada, Sami J.
AU - Ghetti, Bernardino
AU - Harris, David A.
T1 - Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice.
JO - EMBO Journal
JF - EMBO Journal
Y1 - 2007/06/07/
VL - 26
IS - 11
M3 - Article
SP - 2777
EP - 2785
SN - 02614189
AB - Familial prion diseases are due to dominantly inherited, germline mutations in the PRNP gene that encodes the prion protein (PrP). The cellular mechanism underlying the pathogenic effect of these mutations remains uncertain. To investigate whether pathogenic mutations impair a normal, physiological activity of PrP, we have crossed Tg(PG14) mice, which express PrP with an octapeptide insertion associated with an inherited prion dementia, with Tg(PrPΔ32–134) mice. Tg(PrPΔ32–134) mice, which express an N-terminally truncated form of PrP, spontaneously develop a neurodegenerative phenotype that is stoichiometrically reversed by coexpression of wild-type PrP. We find that, at equivalent expression levels, PG14 PrP is significantly less efficient than wild-type PrP in suppressing the development of clinical symptoms and neuropathology in Tg(PrPΔ32–134) mice. Thus, our results suggest that some features of the neurological illness associated with inherited PrP mutations may be attributable to a loss of PrP neuroprotective function. This mechanism stands in contrast to the toxic gain-of-function mechanisms that are usually invoked to explain the pathogenesis of dominantly inherited neurodegenerative disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of EMBO Journal is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRION diseases
KW - COMMUNICABLE diseases
KW - MUTATION (Biology)
KW - GENETICS
KW - PRIONS
KW - PROTEINS
KW - mutation
KW - neuroprotection
KW - octapeptide
KW - prion
KW - transgenic
N1 - Accession Number: 25299129; Li, Aimin 1 Piccardo, Pedro 2,3 Barmada, Sami J. 1 Ghetti, Bernardino 2 Harris, David A. 1; Email Address: dharris@wustl.edu; Affiliation: 1: Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA 2: Division of Neuropathology, Indiana University School of Medicine, Indianapolis, IN, USA 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Source Info: 6/7/2007, Vol. 26 Issue 11, p2777; Subject Term: PRION diseases; Subject Term: COMMUNICABLE diseases; Subject Term: MUTATION (Biology); Subject Term: GENETICS; Subject Term: PRIONS; Subject Term: PROTEINS; Author-Supplied Keyword: mutation; Author-Supplied Keyword: neuroprotection; Author-Supplied Keyword: octapeptide; Author-Supplied Keyword: prion; Author-Supplied Keyword: transgenic; Number of Pages: 9p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1038/sj.emboj.7601726
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25299129&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Atrasheuskaya, Alena V.
AU - Blatun, Elena M.
AU - Kulak, Michail V.
AU - Atrasheuskaya, Alina
AU - Karpov, Igor A.
AU - Rubin, Steven
AU - Ignatyev, George M.
T1 - Investigation of mumps vaccine failures in Minsk, Belarus, 2001–2003
JO - Vaccine
JF - Vaccine
Y1 - 2007/06/11/
VL - 25
IS - 24
M3 - Article
SP - 4651
EP - 4658
SN - 0264410X
AB - Abstract: The purpose of this study was to investigate mumps vaccine failures (VF) in a highly vaccinated population of Minsk, Belarus, and to investigate a possible role for virus strain-specific immunity. During our 3-year study period, 22 adults were admitted to the Infectious Diseases Hospital in Minsk with a diagnosis of mumps. A genotype H1 mumps virus (MuV) strain was identified in all patients. Of 15 patients from whom the paired sera were collected, 9 were confirmed to have been previously vaccinated. Serological examinations indicated primary VF in seven of these cases and secondary VF in two. Despite almost all vaccinated patients possessing MuV specific IgG, few possessed neutralizing antibody to the vaccine strain and titers were nominal. Importantly, none of the sera were able to neutralize a genotype H MuV strain. Our results demonstrate the importance of assaying for neutralizing antibody and support the assertion that antigenic differences between wild type and vaccine MuV strains may play a role in cases of breakthrough infection in vaccinees. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - DISEASES
KW - Mumps
KW - Parotid glands
KW - Immunoglobulin G
KW - Viral vaccines
KW - Belarus
KW - Mumps genotyping
KW - Vaccine failure
N1 - Accession Number: 25107319; Atrasheuskaya, Alena V. 1; Email Address: marburgman3@infonet.by; Blatun, Elena M. 2; Kulak, Michail V. 1; Atrasheuskaya, Alina 3; Karpov, Igor A. 3; Rubin, Steven 4; Ignatyev, George M. 1; Affiliations: 1: State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk Region 630559, Russia; 2: Hospital of Infectious Diseases, Minsk 220050, Belarus; 3: Infectious Diseases Department, State Medical University, Minsk 220116, Belarus; 4: Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA; Issue Info: Jun2007, Vol. 25 Issue 24, p4651; Thesaurus Term: VACCINATION; Thesaurus Term: DISEASES; Subject Term: Mumps; Subject Term: Parotid glands; Subject Term: Immunoglobulin G; Subject Term: Viral vaccines; Author-Supplied Keyword: Belarus; Author-Supplied Keyword: Mumps genotyping; Author-Supplied Keyword: Vaccine failure; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25107319&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reese, David H.
AU - Ramos-Valle, Moraima
T1 - A high-throughput method for monitoring changes in homeobox gene expression
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2007/06/15/
VL - 357
IS - 4
M3 - Article
SP - 882
EP - 888
SN - 0006291X
AB - Abstract: Members of the homeobox gene superfamily of transcription factors are essential determinants of cellular identity during development. Their regulation and downstream gene targets are not well understood, however. This is due, in part, to the large number of genes that need to be analyzed simultaneously. A method has been developed for the rapid and simultaneous detection of changes in the expression of homeobox-containing genes, including members of the developmentally important Hox gene family. The method selectively amplifies and labels homeobox-containing mRNAs using a 3′-RACE procedure in combination with a degenerate forward primer that targets a highly conserved region of the homeobox found in all vertebrate Hox genes and many non-Hox homeobox-containing genes. The amplified sequences are identified by hybridization to a membrane-based array of covalently bound Hox and non-Hox homeobox gene sequences of interest. The method has been used here to demonstrate previously undetected changes in the expression of homeobox genes during retinoic acid-induced nerve cell differentiation in mouse pluripotent P19 cells. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - GENETIC regulation
KW - HOMEOBOX genes
KW - HYBRIDIZATION
KW - EC cells
KW - Homeobox
KW - Hox
KW - P19 cells
KW - Pluripotent
KW - Stem cells
N1 - Accession Number: 25031451; Reese, David H. 1; Email Address: david.reese@fda.hhs.gov Ramos-Valle, Moraima 2; Affiliation: 1: Division of Molecular Biology, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA 2: Division of Toxicology, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708, USA; Source Info: Jun2007, Vol. 357 Issue 4, p882; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: HOMEOBOX genes; Subject Term: HYBRIDIZATION; Author-Supplied Keyword: EC cells; Author-Supplied Keyword: Homeobox; Author-Supplied Keyword: Hox; Author-Supplied Keyword: P19 cells; Author-Supplied Keyword: Pluripotent; Author-Supplied Keyword: Stem cells; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2007.04.040
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106135802
T1 - Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women.
AU - Cook JA
AU - Grey DD
AU - Burke-Miller JK
AU - Cohen MH
AU - Vlahov D
AU - Kapadia F
AU - Wilson TE
AU - Cook R
AU - Schwartz RM
AU - Golub ET
AU - Anastos K
AU - Ponath C
AU - Goparaju L
AU - Levine AM
AU - Cook, Judith A
AU - Grey, Dennis D
AU - Burke-Miller, Jane K
AU - Cohen, Mardge H
AU - Vlahov, David
AU - Kapadia, Farzana
Y1 - 2007/06/15/
N1 - Accession Number: 106135802. Language: English. Entry Date: 20070817. Revision Date: 20161114. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Psychiatry/Psychology. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: U01 AI042590/AI/NIAID NIH HHS/United States. NLM UID: 7513587.
KW - Antiretroviral Therapy, Highly Active
KW - Depression
KW - HIV-Infected Patients -- United States
KW - Street Drugs
KW - Substance Abuse
KW - Women -- United States
KW - Bivariate Statistics
KW - Center for Epidemiological Studies Depression Scale
KW - Correlational Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Logistic Regression
KW - Odds Ratio
KW - Scales
KW - Self Report
KW - United States
KW - Univariate Statistics
KW - Human
SP - 74
EP - 81
JO - Drug & Alcohol Dependence
JF - Drug & Alcohol Dependence
JA - DRUG ALCOHOL DEPENDENCE
VL - 89
IS - 1
PB - Elsevier Science
AB - Background: We examined the interaction of illicit drug use and depressive symptoms, and how they affect the subsequent likelihood of highly active antiretroviral therapy (HAART) use among women with HIV/AIDS.Methods: Subjects included 1710 HIV-positive women recruited from six sites in the U.S. including Brooklyn, Bronx, Chicago, Los Angeles, San Francisco/Bay Area, and Washington, DC. Cases of probable depression were identified using depressive symptom scores on the Center for Epidemiologic Studies Depression Scale. Crack, cocaine, heroin, and amphetamine use were self-reported at 6-month time intervals. We conducted multivariate random logistic regression analysis of data collected during 16 waves of semiannual interviews conducted from April 1996 through March 2004.Results: We found an interaction effect between illicit drug use and depression that acted to suppress subsequent HAART use, controlling for virologic and immunologic indicators, socio-demographic variables, time, and study site.Conclusions: This is the first study to document the interactive effects of drug use and depressive symptoms on reduced likelihood of HAART use in a national cohort of women. Since evidence-based behavioral health and antiretroviral therapies for each of these three conditions are now available, comprehensive HIV treatment is an achievable public health goal.
SN - 0376-8716
AD - Center on Mental Health Services Research and Policy, Department of Psychiatry M/C 912, University of Illinois at Chicago, 1601 W. Taylor Street M/C 912, Chicago, IL 60612, USA
U2 - PMID: 17291696.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Luecke, Richard H.
AU - Pearce, Bruce A.
AU - Wosilait, Walter D.
AU - Slikker, William
AU - Young, John F.
T1 - Postnatal Growth Considerations for PBPK Modeling.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/06/15/
VL - 70
IS - 12
M3 - Article
SP - 1027
EP - 1037
SN - 15287394
AB - A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs, rats, and mice are an integral part of the software and are utilized to assign the appropriate weight and blood flow for each of 22 organs/tissues for each simulation. Upper limits of body weight were chosen that reflect the available data used to define the algorithms; above these limits a set percent body weight was assigned to all organs/tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POSTNATAL care
KW - PHARMACOKINETICS
KW - BODY weight
KW - ANIMAL models in research
KW - ORGANS (Anatomy)
KW - TOXICOLOGY
KW - RESEARCH
KW - ANIMAL experimentation
KW - BLOOD flow
KW - ENVIRONMENTAL health
N1 - Accession Number: 25084589; Luecke, Richard H. 1; Email Address: LueckeR@missouri.edu Pearce, Bruce A. 2 Wosilait, Walter D. 3 Slikker, William 4 Young, John F. 5; Affiliation: 1: Department of Chemical Engineering, University of Missouri-Columbia. Columbia, Missouri, USA 2: Office of Information Technology, National Center for Toxicological Research/FDA/DHHS, Jefferson, Arkansas, USA 3: Department of Pharmacology, University of Missouri-Columbia, Columbia, Missouri, USA 4: Office of the Director, National Center for Toxicological Research/FDA/DHHS. Jefferson, Arkansas, USA 5: Division of Biometry and Risk Assessment, National Center for Toxicological Research/FDA/DHHS, Jefferson, Arkansas, USA; Source Info: Jun2007, Vol. 70 Issue 12, p1027; Subject Term: POSTNATAL care; Subject Term: PHARMACOKINETICS; Subject Term: BODY weight; Subject Term: ANIMAL models in research; Subject Term: ORGANS (Anatomy); Subject Term: TOXICOLOGY; Subject Term: RESEARCH; Subject Term: ANIMAL experimentation; Subject Term: BLOOD flow; Subject Term: ENVIRONMENTAL health; Number of Pages: 11p; Document Type: Article
L3 - 10.1080/15287390601172056
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106181414
T1 - Perceived job stress and sleep-related breathing disturbance in Japanese male workers.
AU - Nakata A
AU - Takahashi M
AU - Ikeda T
AU - Haratani T
AU - Hojou M
AU - Araki S
Y1 - 2007/06/15/
N1 - Accession Number: 106181414. Language: English. Entry Date: 20071102. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Special Interest: Social Work. Instrumentation: Generic Job Stress Questionnaire (GJSQ) [Japanese]; Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Supported in part by appointment to the Research Participation Program at the Centers for Disease Control and Prevention, National Institute of Occupational Safety and Health through an interagency agreement between the US Department of Energy and CDC; and the Japanese Ministry of Education, Culture, Sports, Science and Technology (16659634). NLM UID: 8303205.
KW - Men
KW - Sleep Apnea, Obstructive -- Epidemiology
KW - Sleep Apnea, Obstructive -- Etiology
KW - Sleep Apnea, Obstructive -- Psychosocial Factors
KW - Stress, Occupational
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Center for Epidemiological Studies Depression Scale
KW - Coefficient Alpha
KW - Cross Sectional Studies
KW - Funding Source
KW - Japan
KW - Logistic Regression
KW - Middle Age
KW - Multivariate Analysis
KW - Psychological Tests
KW - Questionnaires
KW - Sleep Apnea, Obstructive -- Risk Factors
KW - Univariate Statistics
KW - Human
SP - 2520
EP - 2532
JO - Social Science & Medicine
JF - Social Science & Medicine
JA - SOC SCI MED
VL - 64
IS - 12
PB - Pergamon Press - An Imprint of Elsevier Science
AB - To examine the association of job stress with sleep-related breathing disturbance (SBD), a cross-sectional sample of 1940 males aged 17-83 (mean 45) years in 292 small and medium-sized enterprises in Japan were surveyed by means of a self-administered questionnaire. Perceived job stress was evaluated by the Japanese version of the Generic Job Stress Questionnaire developed by the US National Institute for Occupational Safety and Health, which included 13 job stress variables. Participants were divided into thirds according to their job stress scores. SBD was assessed by the question 'Have you ever felt difficulty breathing during sleep or has anyone in your family told you that you have such difficulty?' SBD was defined as presence of symptoms more than once a month. Risk of SBD through job stress was estimated using logistic regression with odds ratios (ORs) and 95% confidence intervals (CIs) as measures of association. Prevalence of study-defined SBD was 6.7%. Participants who perceived the lowest level of social support from supervisors, and highest levels of job future ambiguity, interpersonal conflict at the workplace, job dissatisfaction, variance in workload, and quantitative workload had significantly increased risk of SBD after adjusting for potential confounders. High depressive symptoms, as measured by Center for Epidemiologic Studies Depression scale scores of 16 or higher, were also significantly associated with increased SDB. Although the results should be considered preliminary because of the self-reporting and cross-sectional design, data suggest that exposure to high job stress could be a possible risk factor for developing or aggravating SBD. Results also indicate that job stress should be considered when evaluating SBD in occupational and clinical settings.
SN - 0277-9536
AD - National Institute of Occupational Safety and Health, Japan.
U2 - PMID: 17433513.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roberts, Jenny R.
AU - Young, Shih-Houng
AU - Castranova, Vincent
AU - Antonini, James M.
T1 - Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/06/15/
VL - 221
IS - 3
M3 - Article
SP - 306
EP - 319
SN - 0041008X
AB - Abstract: The soluble metals of the pollutant, residual oil fly ash (ROFA), have been shown to alter pulmonary bacterial clearance in rats. The goal of this study was to determine the potential effects on both the innate and adaptive lung immune responses after bacterial infection in rats pre-exposed to the soluble metals in ROFA. Sprague-Dawley rats were intratracheally dosed (i.t.) at day 0 with ROFA (R-Total) (1.0 mg/100 g body weight), the soluble fraction of ROFA (R-Soluble), the soluble sample subject to a chelator (R-Chelex), or phosphate-buffered saline (Saline). On day 3, rats were administered an i.t. dose of 5×104 Listeria monocytogenes. On days 6, 8, and 10, bacterial pulmonary clearance was monitored and bronchoalveolar lavage (BAL) was performed on days 3 (pre-infection), 6, 8, and 10. A concentrated first fraction of lavage fluid was retained for analysis of lactate dehydrogenase and albumin to assess lung injury. BAL cell number, phenotype, and production of reactive oxygen (ROS) and nitrogen species (RNS) were assessed, and a variety of cytokines were measured in the BAL fluid. Rats pre-treated with R-Soluble showed elevated lung injury/cytotoxicity and increased cellular influx into the lungs. R-Soluble-treatment also altered ROS, RNS, and cytokine levels, and caused a degree of macrophage and T cell inhibition. These effects of R-Soluble result in increased pulmonary bacterial burden after infection. The results suggest that soluble metals in ROFA increase lung injury and inflammation, and alter both innate and adaptive pulmonary immune responses. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - MACROPHAGES
KW - T cells
KW - CYTOKINES
KW - Alveolar macrophage
KW - Cytokines
KW - Listeria monocytogenes
KW - ROFA
N1 - Accession Number: 25315995; Roberts, Jenny R. 1,2; Email Address: jur6@cdc.gov Young, Shih-Houng 1 Castranova, Vincent 1,2 Antonini, James M. 1,2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: West Virginia University, Morgantown, WV 26505, USA; Source Info: Jun2007, Vol. 221 Issue 3, p306; Subject Term: LISTERIA monocytogenes; Subject Term: MACROPHAGES; Subject Term: T cells; Subject Term: CYTOKINES; Author-Supplied Keyword: Alveolar macrophage; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: ROFA; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.taap.2007.03.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhong, Xiao-Song
AU - Liu, Ling-Zhi
AU - Skinner, Heath D.
AU - Cao, Zongxian
AU - Ding, Min
AU - Jiang, Bing-Hua
T1 - Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2007/06/22/
VL - 358
IS - 1
M3 - Article
SP - 92
EP - 98
SN - 0006291X
AB - Abstract: Cisplatin (CDDP) and its analogues are widely used for the treatment of a variety of human solid tumors. However, the molecular mechanism of its action remains to be understood. Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis and is upregulated in many human cancers. In this study we demonstrated that CDDP-inhibited VEGF expression in human ovarian cancer cells. We found that CDDP inhibited the VEGF reporter activity in a dose-dependent manner, indicating that CDDP-inhibited transcriptional activation of VEGF. We also found that: (1) luciferase activity mediated by the VEGF reporter containing a mutation of the HIF-1 binding site was much lower than that of the reporter containing a wild-type HIF-1 binding site in ovarian cancer cells, thus confirming that HIF-1 is a major transcriptional regulator of VEGF expression; and that (2) CDDP greatly inhibited VEGF reporter activity containing the wild-type but not the mutant HIF-1 binding site. This result indicates that CDDP-inhibited VEGF transcriptional activation specifically by decreasing HIF-1 activity. Co-transfection of a dominant negative construct of HIF-1 inhibited VEGF reporter activity in ovarian cancer cells. CDDP-inhibited VEGF transcriptional activation specifically through the expression of HIF-1α, but not HIF-1β. We demonstrated that VEGF receptor KDR was expressed in ovarian cancer cells, and that CDDP-inhibited VEGF expression was linked with cellular apoptosis, which was rescued by VEGF treatment. These results suggest a novel mechanism of CDDP’s anti-tumor activity in ovarian cancer cells via HIF-1 expression and VEGF transcriptional activation. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VASCULAR endothelial growth factors
KW - CISPLATIN
KW - CANCER cells
KW - OVARIAN cancer
KW - Angiogenesis
KW - Cisplatin
KW - cisplatin ( CDDP )
KW - HIF-1
KW - hypoxia-inducible factor 1 ( HIF-1 )
KW - Ovarian cancer
KW - vascular endothelial growth factor ( VEGF )
KW - VEGF
KW - VEGF receptor 2 ( KDR )
N1 - Accession Number: 25031516; Zhong, Xiao-Song 1,2 Liu, Ling-Zhi 1 Skinner, Heath D. 2 Cao, Zongxian 2 Ding, Min 3 Jiang, Bing-Hua 1; Email Address: bhjiang@njmu.edu.cn; Affiliation: 1: Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 2: Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA 3: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA; Source Info: Jun2007, Vol. 358 Issue 1, p92; Subject Term: VASCULAR endothelial growth factors; Subject Term: CISPLATIN; Subject Term: CANCER cells; Subject Term: OVARIAN cancer; Author-Supplied Keyword: Angiogenesis; Author-Supplied Keyword: Cisplatin; Author-Supplied Keyword: cisplatin ( CDDP ); Author-Supplied Keyword: HIF-1; Author-Supplied Keyword: hypoxia-inducible factor 1 ( HIF-1 ); Author-Supplied Keyword: Ovarian cancer; Author-Supplied Keyword: vascular endothelial growth factor ( VEGF ); Author-Supplied Keyword: VEGF; Author-Supplied Keyword: VEGF receptor 2 ( KDR ); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.bbrc.2007.04.083
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105882806
T1 - Tools for the new generation.
AU - Clark HW
Y1 - 2007/07//2007 Jul-Aug
N1 - Accession Number: 105882806. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; USA. Special Interest: Psychiatry/Psychology. NLM UID: 101176508.
KW - Counseling -- Methods
KW - Substance Dependence -- Therapy
KW - Comorbidity
KW - Mental Disorders -- Complications
KW - Organizations
KW - Personnel Recruitment
KW - Stress Disorders, Post-Traumatic -- Complications
SP - 42
EP - 43
JO - Addiction Professional
JF - Addiction Professional
JA - ADDICT PROF
VL - 5
IS - 4
CY - New York, New York
PB - Vendome Group LLC
AB - To be effective, today 's counselors must be skilled in addressing the complex needs of clients with co-occurring mental health disorders.
SN - 1542-8435
AD - Substance Abuse and Mental Health Services Administration
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Traci Galinsky
AU - Naomi Swanson
AU - Steven Sauter
AU - Robin Dunkin
AU - Joseph Hurrell
AU - Lawrence Schleifer
T1 - Supplementary breaks and stretching exercises for data entry operators: A follow‐up field studyThis article is a US Government work and, as such, is in the public domain in the United States of America.The conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Saftey and Health or the Internal Revenue Service.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/07//
VL - 50
IS - 7
M3 - Article
SP - 519
EP - 527
SN - 02713586
AB - This study expanded previous NIOSH‐IRS research examining the effects of rest breaks and stretching exercises on symptoms and performance in data‐entry workers.All workers spent 4 weeks with conventional breaks (two 15 min breaks per day) and 4 weeks with supplementary breaks (two 15 min breaks plus four 5 min breaks per day). One‐half were assigned at random to a group instructed to perform brief stretching exercises during breaks. The remainder comprised the “no stretching” (control) group.51 workers (stretch group n = 21; no stretch group n = 30) completed the study symptom questionnaires. Discomfort and eyestrain were significantly lower with supplementary breaks, and supplementary breaks attenuated accumulation of discomfort and eyestrain during work sessions. Data‐entry speed was significantly faster with supplementary breaks so that work output was maintained, despite replacing 20 min of work time with break time. In the stretch group, workers reported stretching during only 25% of conventional breaks and 39% of supplementary breaks, and no significant effects of stretching on discomfort or performance were observed.These results provide further converging evidence that supplementary breaks reliably minimize discomfort and eyestrain without impairing productivity. Low compliance in performing stretches prevented valid assessment of stretching effects. Further research on stretching exercises and exercise compliance is warranted. Am. J. Ind. Med. 50:519–527, 2007. Published 2007 Wiley‐Liss, Inc. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Industrial Medicine is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Research
KW - Employees
KW - Performance standards
KW - United States
N1 - Accession Number: 25464768; Traci Galinsky 1; Naomi Swanson 1; Steven Sauter 1; Robin Dunkin 1; Joseph Hurrell 1; Lawrence Schleifer 2; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio; 2: Internal Revenue Service (IRS), Washington, District of Columbia; Issue Info: Jul2007, Vol. 50 Issue 7, p519; Thesaurus Term: Research; Subject Term: Employees; Subject Term: Performance standards; Subject: United States; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schneider, Diana L.
AU - Lobato, Mark N.
T1 - Tuberculosis Control Among People in U.S. Immigration and Customs Enforcement Custody
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2007/07//Jul2007 Supplement
VL - 33
IS - 1
M3 - Article
SP - 9
EP - 14
SN - 07493797
AB - Background: People detained by United States Immigration and Customs Enforcement (ICE) are a high-risk population for tuberculosis (TB). Detainees are screened for TB upon intake, and TB patients are reported to the Division of Immigration Health Services (DIHS). Methods: TB case reports were reviewed for ICE detainees reported to DIHS during 2004–2005. Case counts and frequency distributions are presented. Case counts are stratified by demographic characteristics, release status, laboratory and clinical findings, HIV/AIDS status, and drug resistance. Case rates were calculated for patients housed at facilities with DIHS staffing. Duration of treatment and of ICE custody is provided. Analyses were conducted in 2006. Results: During 2004 and 2005, 76 and 142 TB patients were reported, respectively. The TB case rate was 82.6/100,000 in 2004 and 121.5/100,000 in 2005. The culture-confirmed case rate of 55.8/100,000 in 2005 was 2.5 times higher than the case rate in the U.S. foreign-born population. Of 218 patients, 127 (58.3%) had Mycobacterium tuberculosis–positive sputum cultures, 70 (32.1%) had acid-fast bacilli–positive sputum smears, and 36 (16.5%) were symptomatic at diagnosis. Patients from Mexico, Honduras, Guatemala, and El Salvador accounted for 184 cases (84.4%) and 184 patients (84.4%) were repatriated. TB patients spent an average 82.6 days in treatment before release or repatriation. Conclusions: Screening at intake to ICE custody has helped DIHS staff in diagnosing TB and starting patients on treatment, but patients are usually deported before completing therapy. Because of deportation, and sometimes re-entry into the United States, unique collaborations are required to support completion of treatment. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIAL diseases
KW - LUNG diseases
KW - TUBERCULOSIS
KW - EMIGRATION & immigration
N1 - Accession Number: 25410941; Schneider, Diana L. 1; Email Address: Diana.Schneider@dhs.gov Lobato, Mark N. 2; Affiliation: 1: Division of Immigration Health Services, U.S. Public Health Service, Washington, DC 2: Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Jul2007 Supplement, Vol. 33 Issue 1, p9; Subject Term: MYCOBACTERIAL diseases; Subject Term: LUNG diseases; Subject Term: TUBERCULOSIS; Subject Term: EMIGRATION & immigration; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.amepre.2007.02.044
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Diane Wysowski
T1 - Propofol Infusion Syndrome: Is There Any More Information?
JO - Anesthesiology
JF - Anesthesiology
Y1 - 2007/07//
VL - 107
IS - 1
M3 - Article
SP - 176
EP - 176
SN - 00033022
N1 - Accession Number: 25467856; Diane Wysowski 1; Affiliation: 1: *US Food and Drug Administration, Silver Spring, Maryland. diane.wysowski@fda.hhs.gov; Source Info: Jul2007, Vol. 107 Issue 1, p176; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106154172
T1 - TeamSTEPPS: Optimizing Teamwork in the Perioperative Setting.
AU - Clancy CM
Y1 - 2007/07//
N1 - Accession Number: 106154172. Language: English. Entry Date: 20070914. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 0372403.
KW - Operating Room Personnel -- Education
KW - Operating Rooms -- Administration
KW - Staff Development
KW - Teamwork -- Education
KW - AORN
KW - Government Agencies -- United States
KW - Patient Safety
KW - Program Implementation
KW - Teaching Materials
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 18
EP - 22
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 86
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 17621444.
DO - 10.1016/j.aorn.2007.06.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106154172&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kothary, M. H.
AU - McCardell, B. A.
AU - Frazar, C. D.
AU - Deer, D.
AU - Tall, B. D.
T1 - Characterization of the Zinc-Containing Metalloprotease Encoded by zpx and Development of a Species-Specific Detection Method for Enterobacter sakazakii.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/07//
VL - 73
IS - 13
M3 - Article
SP - 4142
EP - 4151
SN - 00992240
AB - Enterobacter sakazakii causes a severe form of neonatal meningitis that occurs as sporadic cases as well as outbreaks. The disease has been epidemiologically associated with consumption of reconstituted, dried infant formulas. Very little information is available regarding pathogenicity of the organism and production of virulence factors. Clinical and environmental strains were screened for production of factors which have activity against Chinese hamster ovary (CHO) cells in tissue culture. Polymyxin B lysate and sonicate preparations but not culture supernatants from the strains caused ‘rounding’ of CHO cells. Subsequent studies showed that the CHO cell-rounding factor is a proteolytic enzyme that has activity against azocasein. The cell-bound protease was isolated by using a combination of polymyxin B lysis, followed by sonication of cells harvested from tryptone broth. The protease was purified to homogeneity by sequential ammonium sulfate precipitation, gel filtration chromatography with Sephadex G-100, hydrophobic inter- action chromatography with phenyl-Sepharose CL-4B, and a second gel filtration with Sephadex G-100. In addition to activity against azocasein, the purified protease also exhibits activity against azocoll and insoluble casein but not elastin. The protease has a molecular weight of 38,000 and an isoelectric point of 4.4. It is heat labile and for maximal activity against azocasein has an optimum temperature of 37°C and a pH range of 5 to 7. Proteolytic activity is inhibited by ortho-phenanthroline and Zincov but is not affected by phenylmethylsulfonyl fluoride, N-ethylmaleimide, and trypsin inhibitors, which demonstrates that the protease is a zinc-containing metalloprotease. The metalloprotease does not hemagglutinate chicken or sheep erythrocytes. Twenty-three to 27 of the first 42 N-terminal amino acid residues of the metalloprotease are identical to proteases produced by Serratia proteamaculans, Pectobacterium carotovorum, and Anabaena sp. PCR analysis using primers designed from a consensus nucleotide sequence showed that 135 E. sakazakii strains possessed the metalloprotease gene, zpx, and 25 non-E. sakazakii strains did not. The cloned zpx gene of strain 29544 consists of 1,026 nucleotides, and the deduced amino acid sequence of the metalloprotease has 341 amino acid residues, which corresponds to a theoretical protein size of 37,782 with a theoretical p1 of 5.23. The sequence possesses three well-characterized zinc-binding and active-site motifs present in other bacterial zinc metalloproteases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - METALLOPROTEINASES
KW - MENINGITIS
KW - NEONATOLOGY
KW - ZINC
KW - GEL permeation chromatography
KW - AMMONIUM sulfate -- Physiological effect
KW - NUCLEOTIDE sequence
KW - GENE expression
KW - RNA
N1 - Accession Number: 25847339; Kothary, M. H. 1; Email Address: mahendra.kothary@fda.hhs.gov McCardell, B. A. 1 Frazar, C. D. 1 Deer, D. 1 Tall, B. D. 1; Affiliation: 1: US. Food and Drug Administration, Laurel, Maryland 20708; Source Info: Jul2007, Vol. 73 Issue 13, p4142; Subject Term: ENTEROBACTERIACEAE; Subject Term: METALLOPROTEINASES; Subject Term: MENINGITIS; Subject Term: NEONATOLOGY; Subject Term: ZINC; Subject Term: GEL permeation chromatography; Subject Term: AMMONIUM sulfate -- Physiological effect; Subject Term: NUCLEOTIDE sequence; Subject Term: GENE expression; Subject Term: RNA; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 10p; Illustrations: 4 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1128/AEM.02729-06
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Graczyk, Thaddeus K.
AU - Sunderland, Deirdre
AU - Rule, Ana M.
AU - da Silva, Alexandre J.
AU - Moura, Laci N. S.
AU - Tamang, Leena
AU - Girouard, Autumn S.
AU - Schwab, Kellogg J.
AU - Breysse, Patrick N.
T1 - Urban Feral Pigeons (Columba livia) as a Source for Air- and Waterborne Contamination with Enterocytozoon bieneusi Spores.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/07//
VL - 73
IS - 13
M3 - Article
SP - 4357
EP - 4358
SN - 00992240
AB - This study demonstrated that a person with 30 min of occupational or nonoccupational exposure to urban feral pigeons, such as exposure through the cleaning of surfaces contaminated with pigeon excrement, could inhale approximately 3.5 × 103 Enterocytozoon bieneusi spores and that 1.3 × 103 spores could be inhaled by a nearby person. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SANITARY engineering -- Research
KW - FERAL pigeons
KW - WATERBORNE infection
KW - MICROSPORIDIA
KW - POLLUTANTS
KW - MICROSPORIDIOSIS
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - COMMUNICABLE diseases
N1 - Accession Number: 25847367; Graczyk, Thaddeus K. 1,2; Email Address: tgraczyk@jhsph.edu Sunderland, Deirdre 1 Rule, Ana M. 1 da Silva, Alexandre J. 3 Moura, Laci N. S. 3,4 Tamang, Leena 1 Girouard, Autumn S. 2 Schwab, Kellogg J. 1 Breysse, Patrick N. 1; Affiliation: 1: Division of Environmental Health Engineering, Department of Environmental Health Sciences, School of Public Health, Baltimore, Maryland 21205 2: Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg, School of Public Health, Baltimore, Maryland 21205 3: Division of Parasitic Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, US. Department of Health and Public Services, Atlanta, Georgia 30341 4: Atlanta Research and Education Foundation and Atlanta VA Medical Center, Decatur, Georgia 30333; Source Info: Jul2007, Vol. 73 Issue 13, p4357; Subject Term: SANITARY engineering -- Research; Subject Term: FERAL pigeons; Subject Term: WATERBORNE infection; Subject Term: MICROSPORIDIA; Subject Term: POLLUTANTS; Subject Term: MICROSPORIDIOSIS; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: COMMUNICABLE diseases; NAICS/Industry Codes: 562998 All Other Miscellaneous Waste Management Services; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1128/AEM00202-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liu, Zhi-Jie
AU - Chen, Huizhong
AU - Shaw, Neil
AU - Hopper, Sherryll L.
AU - Chen, Lirong
AU - Chen, Siwei
AU - Cerniglia, Carl E.
AU - Wang, Bi-Cheng
T1 - Crystal structure of an aerobic FMN-dependent azoreductase (AzoA) from Enterococcus faecalis
JO - Archives of Biochemistry & Biophysics
JF - Archives of Biochemistry & Biophysics
Y1 - 2007/07//
VL - 463
IS - 1
M3 - Article
SP - 68
EP - 77
SN - 00039861
AB - Abstract: The initial critical step of reduction of the azo bond during the metabolism of azo dyes is catalyzed by a group of NAD(P)H dependant enzymes called azoreductases. Although several azoreductases have been identified from microorganisms and partially characterized, very little is known about the structural basis for substrate specificity and the nature of catalysis. Enterococcus faecalis azoreductase A (AzoA) is a highly active azoreductase with a broad spectrum of substrate specificity and is capable of degrading a wide variety of azo dyes. Here, we report the crystal structure of the AzoA from E. faecalis determined at 2.07Å resolution with bound FMN ligand. Phases were obtained by single wavelength anomalous scattering of selenomethionine labeled protein crystals. The asymmetric unit consisted of two dimers with one FMN molecule bound to each monomer. The AzoA monomer takes a typical NAD(P)-binding Rossmann fold with a highly conserved FMN binding pocket. A salt bridge between Arg18 and Asp184 restricts the size of the flavin binding pocket such that only FMN can bind. A putative NADH binding site could be identified and a plausible mechanism for substrate reduction is proposed. Expression studies revealed azoA gene to be expressed constitutively in E. faecalis. [Copyright &y& Elsevier]
AB - Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROCOCCUS
KW - BIOCHEMISTRY
KW - SURFACE chemistry
KW - OLIGOMERS
KW - Azoreductase
KW - Commensal microorganism
KW - Enterococcus faecalis
KW - FMN dependent
KW - Gene expression
KW - X-ray crystal structure
N1 - Accession Number: 25316203; Liu, Zhi-Jie 1,2; Email Address: zjliu@ibp.ac.cn Chen, Huizhong 3; Email Address: huizhong.chen@fda.hhs.gov Shaw, Neil 1 Hopper, Sherryll L. 3 Chen, Lirong 2 Chen, Siwei 3 Cerniglia, Carl E. 3 Wang, Bi-Cheng 2; Affiliation: 1: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA 3: Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA; Source Info: Jul2007, Vol. 463 Issue 1, p68; Subject Term: ENTEROCOCCUS; Subject Term: BIOCHEMISTRY; Subject Term: SURFACE chemistry; Subject Term: OLIGOMERS; Author-Supplied Keyword: Azoreductase; Author-Supplied Keyword: Commensal microorganism; Author-Supplied Keyword: Enterococcus faecalis; Author-Supplied Keyword: FMN dependent; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: X-ray crystal structure; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.abb.2007.03.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105818927
T1 - Developmental regression and autism reported to the Vaccine Adverse Event Reporting System.
AU - Woo EJ
AU - Ball R
AU - Landa R
AU - Zimmerman AW
AU - Braun MM
Y1 - 2007/07//
N1 - Accession Number: 105818927. Corporate Author: US Food and Drug Administration. VAERS Working Group, Center for Biologics Evaluation and Research. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Peer Reviewed; UK & Ireland. Special Interest: Pediatric Care; Psychiatry/Psychology. NLM UID: 9713494.
KW - Adverse Drug Event
KW - Autistic Disorder -- Epidemiology
KW - Developmental Disabilities -- Epidemiology
KW - Vaccines -- Adverse Effects
KW - Autistic Disorder -- Diagnosis
KW - Comorbidity
KW - Developmental Disabilities -- Diagnosis
KW - Female
KW - Infant
KW - Interviews
KW - Male
KW - Parents
KW - Resource Databases
KW - United States
KW - Human
SP - 301
EP - 310
JO - Autism: The International Journal of Research & Practice
JF - Autism: The International Journal of Research & Practice
JA - AUTISM
VL - 11
IS - 4
PB - Sage Publications, Ltd.
AB - We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.
SN - 1362-3613
AD - Center for Biologics Evaluation, Research, Food and Drug Administration, Maryland, USA, jane.woo @fda.hhs.gov.
U2 - PMID: 17656395.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Scott Lute
AU - Mark Bailey
AU - Jessica Combs
AU - Muppalla Sukumar
AU - Kurt Brorson
T1 - Phage passage after extended processing in small-virus-retentive filters.
JO - Biotechnology & Applied Biochemistry
JF - Biotechnology & Applied Biochemistry
Y1 - 2007/07//
VL - 047
IS - 3
M3 - Article
SP - 141
EP - 151
SN - 08854513
AB - Retention of a two small phages (ΦX-174 and pp7) by direct-flow small-virus-retentive filters [Viresolve NFP (normal-flow parvovirus), Virosart CPV (canine parvovirus), Ultipor DV20 and Planova 20N] was studied using a commercial-process fluid. Phage passage occurred in each filter type, particularly when overloaded with phage. Clearances of pp7 and ΦX-174 were similar for any given filter brand, arguing that the two phages are equivalent for testing small-virus-retentive filters. The patterns of flux under constant pressure and instantaneous LRV (log reduction value) in relationship to cumulative phage load differed between brands, consistent with the current industry understanding that each brand possesses specific performance attributes. Phages are a powerful and universal tool for evaluating filter performance. Validation of filter performance with phages such as pp7 or ΦX-174 as models for small mammalian viruses represents an attractive alternative to the current practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIOPHAGES
KW - VIRUSES
KW - MICROORGANISMS
KW - FILTERS & filtration
KW - SEPARATION (Technology)
N1 - Accession Number: 25465208; Scott Lute 1 Mark Bailey 2 Jessica Combs 2 Muppalla Sukumar 2 Kurt Brorson 1; Affiliation: 1: Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, U.S.A. 2: Eli Lilly and Company, 307 East McCarty St., Indianapolis, IN 46285, U.S.A.; Source Info: 2007, Vol. 047 Issue 3, p141; Subject Term: BACTERIOPHAGES; Subject Term: VIRUSES; Subject Term: MICROORGANISMS; Subject Term: FILTERS & filtration; Subject Term: SEPARATION (Technology); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scott Lute
AU - Mark Bailey
AU - Jessica Combs
AU - Muppalla Sukumar
AU - Kurt Brorson
T1 - Phage passage after extended processing in small-virus-retentive filters.
JO - Biotechnology & Applied Biochemistry
JF - Biotechnology & Applied Biochemistry
Y1 - 2007/07//
VL - 047
IS - 3
M3 - Article
SP - 141
EP - 151
SN - 08854513
AB - Retention of a two small phages (ΦX-174 and pp7) by direct-flow small-virus-retentive filters [Viresolve NFP (normal-flow parvovirus), Virosart CPV (canine parvovirus), Ultipor DV20 and Planova 20N] was studied using a commercial-process fluid. Phage passage occurred in each filter type, particularly when overloaded with phage. Clearances of pp7 and ΦX-174 were similar for any given filter brand, arguing that the two phages are equivalent for testing small-virus-retentive filters. The patterns of flux under constant pressure and instantaneous LRV (log reduction value) in relationship to cumulative phage load differed between brands, consistent with the current industry understanding that each brand possesses specific performance attributes. Phages are a powerful and universal tool for evaluating filter performance. Validation of filter performance with phages such as pp7 or ΦX-174 as models for small mammalian viruses represents an attractive alternative to the current practice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology & Applied Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteriophages
KW - Viruses
KW - Microorganisms
KW - Filters & filtration
KW - Separation (Technology)
N1 - Accession Number: 25465208; Scott Lute 1; Mark Bailey 2; Jessica Combs 2; Muppalla Sukumar 2; Kurt Brorson 1; Affiliations: 1: Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, U.S.A.; 2: Eli Lilly and Company, 307 East McCarty St., Indianapolis, IN 46285, U.S.A.; Issue Info: 2007, Vol. 047 Issue 3, p141; Thesaurus Term: Bacteriophages; Thesaurus Term: Viruses; Thesaurus Term: Microorganisms; Thesaurus Term: Filters & filtration; Thesaurus Term: Separation (Technology); Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106141856
T1 - Late-breaking news.
AU - Murphey S
AU - Farkouh M
AU - Asayama K
Y1 - 2007/07//2007 Jul
N1 - Accession Number: 106141856. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; brief item. Journal Subset: Consumer Health; USA. Special Interest: Consumer Health. NLM UID: 9891730.
KW - Aspirin
KW - Blood Pressure
KW - Stroke -- Risk Factors
KW - Ibuprofen
KW - Respiratory Protective Devices
SP - 1
EP - 1
JO - Bottom Line Health
JF - Bottom Line Health
JA - BOTTOM LINE HEALTH
VL - 21
IS - 7
CY - Greenwich, Connecticut
PB - Health Confidential
SN - 1092-0129
AD - Branch Chief of Infection, FDA Center for Devices and Radiological Health, Washington, DC
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Slater, J. E.
AU - James, R.
AU - Pongracic, J. A.
AU - Liu, A. H.
AU - Sarpong, S.
AU - Sampson, H. A.
AU - Satinover, S. M.
AU - Woodfolk, J. A.
AU - Mitchell, H. E.
AU - Gergen, P. J.
AU - Eggleston, P. A.
T1 - Biological potency of German cockroach allergen extracts determined in an inner city population.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2007/07//
VL - 37
IS - 7
M3 - Article
SP - 1033
EP - 1039
PB - Wiley-Blackwell
SN - 09547894
AB - Background Cockroach allergy is an important cause of inner city asthma. To perform valid studies on the diagnosis and treatment of cockroach allergy, biological potencies of test extracts need to be established, and a surrogate in vitro test for biological potency should be chosen. Methods Sixty-two cockroach-allergic adult subjects were recruited for quantitative skin testing with three commercial German cockroach extracts. The intradermal D50 values were determined using linear interpolation, and the biologic potencies were determined from D50 data. The extracts were also analysed for relative potency, using a competition ELISA, and for specific allergen content, using a two-site ELISA. Results Estimates of each extract's D50 were analysable in 48–55 subjects, with D50s between 10.3 and 11.8. All three extracts were bioequivalent using pre-set criteria. The biological potencies of the extracts were 1738–8570 bioequivalent allergy units (BAU)/mL (geometric mean=3300), and these relative potencies were similar to those estimated by competition ELISA and specific allergen content. IgE against cockroach allergens were detected in sera from 34 subjects with analysable D50s, and 17 subjects had IgE directed against specific cockroach allergens. Although the presence of anti-Bla g 5 correlated with the subjects' skin test responses for 2/3 extracts, no single allergen was immunodominant. Antibody responses among the subjects were heterogeneous. Conclusions Although commercial cockroach extracts are relatively low in potency, immunotherapeutic doses should be achievable. Biological potency may be estimated using D50 testing, a combination of specific allergen determinations, or by an overall potency assay such as the competition ELISA. Capsule Summary The biological potency of three German cockroach allergen extracts, determined in an inner city population, was 1738–8570 BAU/mL. No one allergen was immunodominant, and surrogate in vitro testing methods were examined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Antigens
KW - Asthma
KW - Cockroaches
KW - Immunotherapy
KW - Standardization
KW - allergen
KW - asthma
KW - cockroach
KW - immunotherapy
KW - standardization
N1 - Accession Number: 25438897; Slater, J. E. 1; Email Address: jay.slater@fda.hhs.gov; James, R. 2; Pongracic, J. A. 3; Liu, A. H. 4; Sarpong, S. 5; Sampson, H. A. 6; Satinover, S. M. 7; Woodfolk, J. A. 7; Mitchell, H. E. 2; Gergen, P. J. 8; Eggleston, P. A. 9; Affiliations: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA; 2: Rho Inc., Chapel Hill, NC, USA; 3: Children's Memorial Hospital, Chicago, IL, USA; 4: National Jewish Medical and Research Center, Denver, CO, USA; 5: Howard University, Washington, DC, USA; 6: Mt. Sinai School of Medicine, New York, NY, USA; 7: University of Virginia Health System, Charlottesville, VA, USA; 8: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; 9: Johns Hopkins University School of Medicine, Baltimore, MD, USA; Issue Info: Jul2007, Vol. 37 Issue 7, p1033; Thesaurus Term: Allergens; Thesaurus Term: Antigens; Thesaurus Term: Asthma; Thesaurus Term: Cockroaches; Subject Term: Immunotherapy; Subject Term: Standardization; Author-Supplied Keyword: allergen; Author-Supplied Keyword: asthma; Author-Supplied Keyword: cockroach; Author-Supplied Keyword: immunotherapy; Author-Supplied Keyword: standardization; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2222.2007.02751.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Atrasheuskaya, A. V.
AU - Kulak, M. V.
AU - Rubin, S.
AU - Ignatyev, G. M.
T1 - Mumps vaccine failure investigation in Novosibirsk, Russia, 2002–2004.
JO - Clinical Microbiology & Infection
JF - Clinical Microbiology & Infection
Y1 - 2007/07//
VL - 13
IS - 7
M3 - Article
SP - 670
EP - 676
PB - Elsevier Science
SN - 1198743X
AB - The aims of this study were to estimate the importance of vaccine failure (VF) in cases of mumps during 2002–2004 in the city of Novosibirsk, Western Siberia, Russia, and to genotype the responsible virus strain. Mumps virus-specific RT-PCR testing of saliva was performed for 18 cases of mumps. Sera were tested for IgM and IgG, IgG avidity, and the ability to neutralise a panel of mumps viruses, including the Leningrad-3 mumps vaccine virus. Of the 12 patients for whom vaccination status was positively determined, 11 showed serological evidence of primary VF. Sequence analysis of virus RNA amplified from saliva revealed a genotype C2 virus in 2002, a genotype H2 virus in 2003, and both genotypes in 2004. Although several vaccinated patients were positive for mumps virus IgG at the time of first sampling, only nominal levels of neutralising antibody were detected, and these were effective in neutralising the vaccine strain, but not genotype C and H mumps virus strains. These results suggest that the majority of cases of mumps in vaccinees are caused by primary VF, defined as either a lack of seroconversion or a lack of IgG maturity, as based on avidity testing. The results also support the hypothesis that sera of low neutralising antibody titre have a limited ability to neutralise heterologous mumps virus strains, suggesting that antigenic differences between circulating and mumps vaccine virus strains may play a role in cases of breakthrough infection. Consistent with previous reports, mumps virus genotypes C and H continue to circulate in Novosibirsk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Microbiology & Infection is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - DISEASES
KW - Virus diseases
KW - Mumps
KW - Vaccines
KW - Parotid glands
KW - Saliva
KW - Viral antibodies
KW - Genotyping
KW - mumps virus
KW - Russia
KW - serology
KW - vaccine failure
N1 - Accession Number: 25276269; Atrasheuskaya, A. V. 1; Email Address: marburgman3@infonet.by; Kulak, M. V. 1; Rubin, S. 2; Ignatyev, G. M. 1; Affiliations: 1: State Research Center of Virology and Biotechnology Vector, Koltsovo, Russia; 2: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Issue Info: Jul2007, Vol. 13 Issue 7, p670; Thesaurus Term: VACCINATION; Thesaurus Term: DISEASES; Thesaurus Term: Virus diseases; Subject Term: Mumps; Subject Term: Vaccines; Subject Term: Parotid glands; Subject Term: Saliva; Subject Term: Viral antibodies; Author-Supplied Keyword: Genotyping; Author-Supplied Keyword: mumps virus; Author-Supplied Keyword: Russia; Author-Supplied Keyword: serology; Author-Supplied Keyword: vaccine failure; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1111/j.1469-0691.2007.01727.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25276269&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - De Simone, Giovanni
AU - Devereux, Richard B.
AU - Chinali, Marcello
AU - Best, Lyle G.
AU - Lee, Elisa T.
AU - Galloway, James M.
AU - Resnick, Helaine E.
T1 - Prognostic Impact of Metabolic Syndrome by Different Definitions in a Population With High Prevalence of Obesity and Diabetes.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2007/07//
VL - 30
IS - 7
M3 - Article
SP - 1851
EP - 1856
SN - 01495992
AB - OBJECTIVE -- This study analyzed which definition of the metabolic syndrome is more predictive of cardiovascular events in both diabetic and nondiabetic members of a populationbased sample. RESEARCH DESIGN AND METHODS -- A 10-year, longitudinal follow-up of the Strong Heart Study cohort has been evaluated. The analysis included 3,945 participants (2,384 female) with complete data (1,700 with diabetes and 1,468 with arterial hypertension) for evaluation of metabolic syndrome. Those with prevalent cardiovascular disease were excluded (n = 287, of whom 127 were female). Prevalence of metabolic syndrome was assessed based on the World Health Organization (WHO), the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III, and International Diabetes Federation (IDF) definitions. The main outcome was 10-year incidence of combined fatal and nonfatal cardiovascular events, including stroke, coronary heart disease, and congestive heart failure. RESULTS -- Fatal and nonfatal cardiovascular events occurred in 1,120 participants. After adjusting for age, sex, and diabetes, metabolic syndrome by all definitions was significantly associated with higher incidence of cardiovascular events (all P < 0.0001). In nondiabetic individuals, incident cardiovascular event rates were about 30-40% higher in those with metabolic syndrome, without a significant difference among definitions (0.03 < P < 0.001), and remained significant in WHO and NCEP ATP III definitions even after further adjustment for obesity, hypertension, and low HDL cholesterol. In the diabetic group, metabolic syndrome risk for cardiovascular events was greatest using the WHO definition (P < 0.002 vs. other models). CONCLUSIONS -- In individuals without diabetes, metabolic syndrome is associated with incident cardiovascular disease, especially with WHO and NCEP ATP III definitions. Metabolic syndrome also predicts higher cardiovascular event rates in diabetic participants, a prediction that is greatest using the WHO definition. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLIC syndrome
KW - CARDIOVASCULAR diseases
KW - DIABETES
KW - OBESITY
KW - HYPERTENSION
KW - DIABETICS
N1 - Accession Number: 26098656; De Simone, Giovanni 1,2; Email Address: simogi@unina.it Devereux, Richard B. 1 Chinali, Marcello 2 Best, Lyle G. 3 Lee, Elisa T. 4 Galloway, James M. 5 Resnick, Helaine E. 6; Affiliation: 1: Division of Cardiology, Weill Medical College of Cornell University, New York, New York 2: Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy 3: Missouri Breaks Industries Research, Timber Lake, South Dakota 4: Center for American Indian Health Research, University of Oklahoma, Oklahoma City, Oklahoma 5: Indian Health Service, University of Arizona, Tucson, Arizona 6: Medstar Research Institute, Washington, DC.; Source Info: Jul2007, Vol. 30 Issue 7, p1851; Subject Term: METABOLIC syndrome; Subject Term: CARDIOVASCULAR diseases; Subject Term: DIABETES; Subject Term: OBESITY; Subject Term: HYPERTENSION; Subject Term: DIABETICS; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 4368
L3 - 10.2337/dc06-2152
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26098656&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY -
AU - Ling Chen1, ling.chen@fda.hhs.gov
AU - Yi Tshong2
T1 - Design and Analysis for Drug Abuse Potential Studies: Issues and Strategies for Implementing a Crossover Design.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/07//
Y1 - 2007/07//
VL - 41
IS - 4
CP - 4
M3 - Article
SP - 481
EP - 489
SN - 00928615
AB - It is important to conduct a drug abuse potential study for a new drug that may have potential to be abused. The acute dose-effect comparisons of the test, positive control, and placebo treatments are often performed on healthy volunteers with histories of drug abuse in drug abuse clinical trials. Because of large between-subject variability in the endpoint measurements based on self-evaluated responses and the difficulty in recruiting appropriate study subjects; the designs for such studies are typically crossover, with self-control. In this article, design issues and statistical analysis issues are presented. The advantages and disadvantages of currently used study designs are discussed. Some new ideas for improving existing designs are proposed. [ABSTRACT FROM AUTHOR]
KW - Drug abuse
KW - Pharmaceutical research
KW - Clinical drug trials
KW - Placebos (Medicine)
KW - Clinical trials
KW - Self-control
KW - Crossover design
KW - Drug abuse polential studies
KW - Mixed carryover effect
KW - Orthogonal Latin squares
KW - Williams design
N1 - Accession Number: 25815404; Authors: Ling Chen 1 Email Address: ling.chen@fda.hhs.gov; Yi Tshong 2; Affiliations: 1: Mathematical Statistician, DB W/Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration; 2: Deputy Director, DB VI/Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration; Subject: Drug abuse; Subject: Pharmaceutical research; Subject: Clinical drug trials; Subject: Placebos (Medicine); Subject: Clinical trials; Subject: Self-control; Author-Supplied Keyword: Crossover design; Author-Supplied Keyword: Drug abuse polential studies; Author-Supplied Keyword: Mixed carryover effect; Author-Supplied Keyword: Orthogonal Latin squares; Author-Supplied Keyword: Williams design; Number of Pages: 9p; Illustrations: 1 Diagram; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY -
AU - Lin, Stan C.1, stan.lin@hhs.fda.gov
T1 - Statistical Considerations for Some Studies of Over-the-Counter Drugs.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/07//
Y1 - 2007/07//
VL - 41
IS - 4
CP - 4
M3 - Article
SP - 511
EP - 516
SN - 00928615
AB - In this article, the label comprehension and actual use studies that may be required for an over-the-counter new drug regulatory submission are introduced. Design for these studies and statistical issues are described. Because confidence interval is a tool that plays a central role in these studies, information needed and appropriate sample size estimation approaches are discussed. Carefully designed and analyzed studies would enhance their success rate and provide more useful information from the studies. [ABSTRACT FROM AUTHOR]
KW - Drugs -- Labeling
KW - Nonprescription drugs
KW - Drug laws & regulations
KW - Confidence intervals
KW - Sample size (Statistics)
KW - Pharmaceutical research
KW - Label comprehension and actual use studies
KW - Over-the-counter drugs
KW - Sample size
KW - Variance estimate
N1 - Accession Number: 25815407; Authors: Lin, Stan C. 1 Email Address: stan.lin@hhs.fda.gov; Affiliations: 1: Division of Biometrics IV, Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Subject: Drugs -- Labeling; Subject: Nonprescription drugs; Subject: Drug laws & regulations; Subject: Confidence intervals; Subject: Sample size (Statistics); Subject: Pharmaceutical research; Author-Supplied Keyword: Label comprehension and actual use studies; Author-Supplied Keyword: Over-the-counter drugs; Author-Supplied Keyword: Sample size; Author-Supplied Keyword: Variance estimate; Number of Pages: 6p; Illustrations: 1 Chart; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Nightingale, Stuart L.
AU - Prasher, Joanna M.
AU - Simonson, Stewart
T1 - Emergency Use Authorization (EUA) to Enable Use of Needed Products in Civilian and Military Emergencies, United States.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/07//
VL - 13
IS - 7
M3 - Article
SP - 1046
EP - 1051
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - The US Emergency Use Authorization (EUA) is a critical new tool for medical and public health communities and is applicable for both civilian and military use. It fills the need for timely and practical medical treatment under emergency conditions and authorizes use of the best product available for treatment or prevention when the relevant product has not already been approved or approved for this specific use by the US Food and Drug Administration. The need for and genesis of the EUA, its requirements, its broad application to civilian and military populations, and its features of particular importance to physicians and public health officials are detailed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Emergency medical services
KW - Medical care
KW - Military medicine
KW - Physicians
KW - Public health personnel
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 25690874; Nightingale, Stuart L. 1,2; Email Address: nightins@od.nih.gov; Prasher, Joanna M. 1; Simonson, Stewart 1,3; Affiliations: 1: US Department of Health and Human Services, Washington, DC, USA; 2: National Institutes of Health, Bethesda, Maryland, USA; 3: Constella Group LLC, Washington, DC, USA; Issue Info: Jul2007, Vol. 13 Issue 7, p1046; Thesaurus Term: Public health; Subject Term: Emergency medical services; Subject Term: Medical care; Subject Term: Military medicine; Subject Term: Physicians; Subject Term: Public health personnel; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martella, Vito
AU - Campolo, Marco
AU - Lorusso, Eleonora
AU - Cavicchio, Paolo
AU - Camero, Michele
AU - Bellacicco, Anna L.
AU - Decaro, Nicola
AU - Elia, Gabriella
AU - Greco, Grazia
AU - Corrente, Marialaura
AU - Desario, Costantina
AU - Arista, Serenella
AU - Banyai, Krisztián
AU - Koopmans, Marion
AU - Buonavoglia, Canio
T1 - Norovirus in Captive Lion Cub (Panthera leo).
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/07//
VL - 13
IS - 7
M3 - Article
SP - 1071
EP - 1074
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - African lions (Panthera leo) are susceptible to viral diseases of domestic carnivores, including feline calicivirus infection. We report the identification of a novel enteric calicivirus, genetically related to human noroviruses of genogroup IV, in a lion cub that died of severe hemorrhagic enteritis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Viruses
KW - Calicivirus infections in animals
KW - Lions
KW - Intestines -- Infections
KW - Enteritis
N1 - Accession Number: 25690880; Martella, Vito 1; Email Address: v.martella@veterinaria.uniba.it; Campolo, Marco 1; Lorusso, Eleonora 1; Cavicchio, Paolo 2; Camero, Michele 1; Bellacicco, Anna L. 1; Decaro, Nicola 1; Elia, Gabriella 1; Greco, Grazia 1; Corrente, Marialaura 1; Desario, Costantina 1; Arista, Serenella 3; Banyai, Krisztián 4; Koopmans, Marion 5; Buonavoglia, Canio 1; Affiliations: 1: University of Bari, Valenzano, Bari, Italy; 2: Giardino Zoologico di Pistoia, Pistoia, Italy; 3: University of Palermo, Palermo, Italy; 4: Baranya County Institute of State Public Health Service, Pécs, Hungary; 5: National Institute of Public Health and Environment, Bilthoven, Netherlands; Issue Info: Jul2007, Vol. 13 Issue 7, p1071; Thesaurus Term: DISEASES; Thesaurus Term: Viruses; Subject Term: Calicivirus infections in animals; Subject Term: Lions; Subject Term: Intestines -- Infections; Subject Term: Enteritis; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Krieg, Edward F.
T1 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey
JO - Environmental Research
JF - Environmental Research
Y1 - 2007/07//
VL - 104
IS - 3
M3 - Article
SP - 374
EP - 382
SN - 00139351
AB - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35–60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to g/dl. The estimated geometric mean was g/dl, and the estimated arithmetic mean was g/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were g/dl for follicle stimulating hormone and g/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries. [Copyright &y& Elsevier]
AB - Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lead -- Toxicology
KW - HEALTH
KW - RESEARCH
KW - Women
KW - Follicle-stimulating hormone
KW - Ovariectomy -- Physiological aspects
KW - Luteinizing hormone
KW - Menopause
KW - Blood lead
KW - Follicle stimulating hormone
KW - FSH
KW - LH
KW - Luteinizing hormone
KW - NHANES III
N1 - Accession Number: 25316275; Krieg, Edward F. 1; Email Address: erk3@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, USA; Issue Info: Jul2007, Vol. 104 Issue 3, p374; Thesaurus Term: Lead -- Toxicology; Thesaurus Term: HEALTH; Thesaurus Term: RESEARCH; Subject Term: Women; Subject Term: Follicle-stimulating hormone; Subject Term: Ovariectomy -- Physiological aspects; Subject Term: Luteinizing hormone; Subject Term: Menopause; Author-Supplied Keyword: Blood lead; Author-Supplied Keyword: Follicle stimulating hormone; Author-Supplied Keyword: FSH; Author-Supplied Keyword: LH; Author-Supplied Keyword: Luteinizing hormone; Author-Supplied Keyword: NHANES III; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.envres.2006.09.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kang, S.J.
AU - Kim, S.H.
AU - Liu, P.
AU - Jovel, E.
AU - Towers, G.H.N.
T1 - Antibacterial activities of some mosses including Hylocomium splendens from South Western British Columbia
JO - Fitoterapia
JF - Fitoterapia
Y1 - 2007/07//
VL - 78
IS - 5
M3 - Article
SP - 373
EP - 376
SN - 0367326X
AB - Abstract: The antibacterial activity of methanol extracts of ten moss species and fractions prepared from 80% methanol extract of Hylocomium splendens were evaluated by disk diffusion method. Nine moss species showed antibacterial activity against Gram (+) bacteria, in particular H. splendens and its ethyl acetate fractions showed stronger activity. Enhancement of antibacterial activity against Staphylococci by UV-A light irradiation was demonstrated in the extracts of Bartramia pomiformis, Ceratodon purpureus and Neckera douglasii. [Copyright &y& Elsevier]
AB - Copyright of Fitoterapia is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBACTERIAL agents
KW - MOSSES
KW - PLANT extracts
KW - METHANOL
KW - Antibacterial activity
KW - Hylocomium splendens
KW - Mosses
N1 - Accession Number: 25618454; Kang, S.J. 1,2; Email Address: sapium@yahoo.com Kim, S.H. 3 Liu, P. 2 Jovel, E. 2 Towers, G.H.N. 2; Affiliation: 1: Korea Food and Drug Administration, Jinheungno, Seoul, 122-704, Republic of Korea 2: Institute for Aboriginal Health, University of British Columbia, 2194 Health Sciences Mall, Vancouver, B.C. V6T1Z3, Canada 3: Department of Microbiology and Institute of Basic Sciences, Dankook University, Cheonan, 330-714, Republic of Korea; Source Info: Jul2007, Vol. 78 Issue 5, p373; Subject Term: ANTIBACTERIAL agents; Subject Term: MOSSES; Subject Term: PLANT extracts; Subject Term: METHANOL; Author-Supplied Keyword: Antibacterial activity; Author-Supplied Keyword: Hylocomium splendens; Author-Supplied Keyword: Mosses; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.fitote.2007.03.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106016993
T1 - Antibacterial activities of some mosses including Hylocomium splendens from South Western British Columbia.
AU - Kang SJ
AU - Kim SH
AU - Liu P
AU - Jovel E
AU - Towers GHN
Y1 - 2007/07//
N1 - Accession Number: 106016993. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Alternative/Complementary Therapies; Continental Europe; Europe; Peer Reviewed. Grant Information: Supported by the Post-doctoral Fellowship Program of Korea Science and Engineering Foundation (KOSEF). NLM UID: 16930290R.
KW - Antibiotics -- Administration and Dosage
KW - Plant Extracts -- Administration and Dosage
KW - Plants, Medicinal -- British Columbia
KW - Alternative Therapies
KW - Bacillus
KW - British Columbia
KW - Descriptive Statistics
KW - Enterococcus
KW - Escherichia Coli
KW - Funding Source
KW - In Vitro Studies
KW - Methicillin Resistance
KW - Microbial Culture and Sensitivity Tests
KW - Pseudomonas
KW - Salmonella
KW - Staphylococcus
KW - Human
SP - 373
EP - 376
JO - Fitoterapia
JF - Fitoterapia
JA - FITOTERAPIA
VL - 78
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - The antibacterial activity of methanol extracts of ten moss species and fractions prepared from 80% methanol extract of Hylocomium splendens were evaluated by disk diffusion method. Nine moss species showed antibacterial activity against Gram (+) bacteria, in particular H. splendens and its ethyl acetate fractions showed stronger activity. Enhancement of antibacterial activity against Staphylococci by UV-A light irradiation was demonstrated in the extracts of Bartramia pomiformis, Ceratodon purpureus and Neckera douglasii.
SN - 0367-326X
AD - Korea Food and Drug Administration, Jinheungno, Seoul, 122-704, Republic of Korea
U2 - PMID: 17553633.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - D'Ovidio, K. L.
AU - Trucksess, M. W.
AU - Devries, J. W.
AU - Bean, G.
T1 - Effects of irradiation on fungi and fumonisin B1 in corn, and of microwave-popping on fumonisins in popcorn.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2007/07//
VL - 24
IS - 7
M3 - Article
SP - 735
EP - 743
PB - Taylor & Francis Ltd
SN - 0265203X
AB - Fumonisins are metabolites produced in corn primarily by the fungus Fusarium verticillioides (F. moniliforme) and are toxic to humans and animals. Fumonisin B1 (FB1) is the primary fumonisin produced and is found frequently in corn kernels, some of which may be used as food or food ingredients. A three-part study was conducted to determine the effects of gamma- and electron beam irradiation on the levels of fumonisins in naturally contaminated field corn, and the effects of microwave-popping on fumonisins in selected, naturally contaminated popcorn. To date, no effective means have been found to reduce consistently mycotoxin levels once foods are contaminated. Aqueous solutions of FB1 at various concentrations, samples of whole corn, and samples of ground corn containing known levels of FB1 were irradiated with various levels of cobalt and electron beam irradiation. Popcorn samples, taken from the reject streams of popcorn processing, were popped using normal microwave-popping conditions. FB1 in aqueous solutions was reduced by 99.7% using a minimal level of irradiation (0.5 kGray). Gamma- and electron beam irradiation did not significantly reduce levels of FB1 in whole and ground corn. Aspergillus sp., Penicillium sp. and Fusarium sp. fungi were totally eliminated at 30 kGray in ground corn and at 100 kGray in whole corn. The normal commercial cleaning processes for microwave popcorn before packaging reduced fumonisins to <0.03 µg g-1 for the cleaned product stream. Microwave popping of popcorn from reject streams of the cleaning operation that contained fumonisins resulted in significant reduction of the mould toxin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Irradiation
KW - Fungi
KW - Corn
KW - Mycotoxins
KW - Poisons
KW - Irradiated foods
KW - Fumonisins
KW - Popcorn
KW - Fusarium
KW - corn
KW - irradiation
KW - mycotoxins
KW - popcorn
N1 - Accession Number: 25728045; D'Ovidio, K. L. 1; Trucksess, M. W. 2; Email Address: mary.trucksess@fda.hhs.gov; Devries, J. W. 3; Bean, G. 1; Affiliations: 1: University of Maryland. College Park, MD. USA; 2: US Food and Drug Administration. College Park, MD. USA; 3: Medallion Laboratories, General Mills Inc.. Minneapolis, MN. USA; Issue Info: Jul2007, Vol. 24 Issue 7, p735; Thesaurus Term: Irradiation; Thesaurus Term: Fungi; Thesaurus Term: Corn; Thesaurus Term: Mycotoxins; Thesaurus Term: Poisons; Thesaurus Term: Irradiated foods; Subject Term: Fumonisins; Subject Term: Popcorn; Subject Term: Fusarium; Author-Supplied Keyword: corn; Author-Supplied Keyword: irradiation; Author-Supplied Keyword: mycotoxins; Author-Supplied Keyword: popcorn; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1080/02652030701216453
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Veldhuijzen, Irene K.
AU - Mostert, Marijke C.
AU - Niesters, Hubert G. M.
AU - Hendrikrichardus, Jan
AU - de Man, Robert A.
T1 - Accuracy of a referral guideline for patients with chronic hepatitis B in primary care to select patients eligible for evaluation by a specialist.
JO - Gut
JF - Gut
Y1 - 2007/07//
VL - 56
IS - 7
M3 - Letter
SP - 1027
EP - 1028
SN - 00175749
AB - A letter to the editor is presented regarding practice guidelines for patients with chronic hepatitis.
KW - LETTERS to the editor
KW - HEPATITIS
KW - PATIENTS
N1 - Accession Number: 25602424; Veldhuijzen, Irene K. 1; Email Address: veldhuijzeni@ggd.rotterdam.nl Mostert, Marijke C. 1 Niesters, Hubert G. M. 2 Hendrikrichardus, Jan 3 de Man, Robert A. 4; Affiliation: 1: Department of Infectious Diseases Control, Municipal Public Health Service Rotterdam Area, Rotterdom, The Netherlands 2: Department of Virology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands 3: Department of Public Health, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands 4: Department of Gastroenterology and Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands; Source Info: Jul2007, Vol. 56 Issue 7, p1027; Subject Term: LETTERS to the editor; Subject Term: HEPATITIS; Subject Term: PATIENTS; Number of Pages: 2p; Document Type: Letter
L3 - 10.1136/gut.2007.122333
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25602424&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Perrin, James M.
AU - Fluet, Christina F.
AU - Honberg, Lynda
AU - Anderson, Betsy
AU - Wells, Nora
AU - Epstein, Susan
AU - Allen, Deborah
AU - Tobias, Carol
AU - Kuhlthau, Karen A.
T1 - Benefits For Employees With Children With Special Needs: Findings From The Collaborative Employee Benefit Study.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/07//Jul/Aug2007
VL - 26
IS - 4
M3 - Article
SP - 1096
EP - 1103
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Approximately 13-15 percent of U.S. children have special health care needs. The demands of their caregiving can affect their parents' health and workplace performance. We interviewed forty-one U.S. employers and conducted focus groups with working parents in four U.S. cities to determine the extent to which employers understand the needs of these families and to identify opportunities for improving workplace benefits for these employees beyond health insurance. Employers saw value in improving workforce performance and employee retention through expanded benefits and indicated promising opportunities to improve their response to the needs of employees with children with chronic conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN with disabilities
KW - CAREGIVERS
KW - WORKING parents
KW - HEALTH insurance
KW - UNITED States
N1 - Accession Number: 25810001; Perrin, James M. 1,2; Email Address: jperrin@partners.org Fluet, Christina F. 3 Honberg, Lynda 4 Anderson, Betsy 5 Wells, Nora 5 Epstein, Susan 6 Allen, Deborah 7 Tobias, Carol 8 Kuhlthau, Karen A. 9; Affiliation: 1: Professor of Pediatrics, Harvard Medical School, Boston. 2: Director, MassGeneral Hospital for Children, Center for Child and Adolescent Health Policy, Boston. 3: Senior Research Coordinator, Center for Child and Adolescent Health Policy, Boston. 4: Senior Program Officer, Health Resources and Services Administration, Maternal and Child Health Bureau, Rockville, Maryland. 5: Coordinators, Federation for Children with Special Needs, Roxbury, Massachusetts. 6: Director, New England SERVE, Health Policy, Research, and Planning Organization, Roxbury. 7: Associate Professor, Boston University School of Public Health, Department of Maternal and Child Health. 8: Director, Health and Disability Working Group, Boston University School of Public Health. 9: Assistant Professor, Department of Pediatrics, Harvard Medical School.; Source Info: Jul/Aug2007, Vol. 26 Issue 4, p1096; Subject Term: CHILDREN with disabilities; Subject Term: CAREGIVERS; Subject Term: WORKING parents; Subject Term: HEALTH insurance; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 8p; Document Type: Article
L3 - 10.1377/hlthaff.26.4.1096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25810001&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mark, Tami L.
AU - Levit, Katharine R.
AU - Vandivort-Warren, Rita
AU - Coffey, Rosanna M.
AU - Buck, Jeffrey A.
T1 - Trends In Spending For Substance Abuse Treatment, 1986-2003.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/07//Jul/Aug2007
VL - 26
IS - 4
M3 - Article
SP - 1118
EP - 1128
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Since 1987, public and private investment in substance abuse (SA) treatment has not kept pace with other health spending. SA treatment spending in the United States grew from $9.3 billion in 1986 to $20.7 billion in 2003. The average annual total growth rate was 4.8 percent. In comparison, total U.S. health care spending grew by 8.0 percent. As a result of the slower growth of SA spending compared to that for all health care, SA spending fell as a share of all health spending from 2.1 percent in 1986 to 1.3 percent in 2003. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - MEDICAL care -- Finance
KW - INVESTMENTS
KW - UNITED States
N1 - Accession Number: 25810004; Mark, Tami L.; Email Address: Tami.Mark@thomson.com Levit, Katharine R. 1 Vandivort-Warren, Rita 2 Coffey, Rosanna M. Buck, Jeffrey A. 3; Affiliation: 1: Senior Research Leader, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland. 2: Public Health Analyst, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland. 3: Chief of Survey, analysis, and Financing Branch, SAMHSA Center for Mental Health Services, Rockville, Maryland.; Source Info: Jul/Aug2007, Vol. 26 Issue 4, p1118; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: MEDICAL care -- Finance; Subject Term: INVESTMENTS; Subject Term: UNITED States; NAICS/Industry Codes: 523999 Miscellaneous Financial Investment Activities; NAICS/Industry Codes: 523930 Investment Advice; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.26.4.1118
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25810004&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McDiarmid, M. A.
AU - Engelhardt, S. M.
AU - Oliver, M.
AU - Gucer, P.
AU - Wilson, P. D.
AU - Kane, R.
AU - Cernich, A.
AU - Kaup, B.
AU - Anderson, L.
AU - Hoover, D.
AU - Brown, L.
AU - Albertini, R.
AU - Gudi, R.
AU - Jacobson-Kram, D.
AU - Squibb, K. S.
T1 - HEALTH SURVEILLANCE OF GULF WAR I VETERANS EXPOSED TO DEPLETED URANIUM: UPDATING THE COHORT.
JO - Health Physics
JF - Health Physics
Y1 - 2007/07//
VL - 93
IS - 1
M3 - Article
SP - 60
EP - 73
SN - 00179078
AB - This article discusses the health surveillance of U. S. Veterans of the 1991 Gulf War who were exposed to depleted uranium (DU) from friendly fire. According to the authors, several of these subjects retain DU shrapnel fragments and many showed elevated levels of uranium in their urine. The subjects were divided into two groups based on uranium urine levels. Results continued to show no evidence of clinically significant DU-related health effects. Continued evidence of a weak genotoxic effect from the DU exposure as measured by HPRT (hypoxanthine-guanine phosphoribosyl transferase) chromosomal mutations and fluorescent in-situ hybridization (FISH) results suggest the need for continued surveillance of this population.
KW - HEALTH
KW - Depleted uranium
KW - Health risk assessment
KW - Genetic toxicology
KW - Veterans
KW - Friendly fire (Military science)
KW - Persian Gulf War, 1991
KW - Urinalysis
KW - Fluorescence in situ hybridization
KW - cumulative
KW - depleted
KW - excretion
KW - exposure
KW - health effects
KW - uranium
KW - urinary
N1 - Accession Number: 25429393; McDiarmid, M. A. 1,2; Engelhardt, S. M. 2; Email Address: sengelha@medicine.umaryland.ed; Oliver, M. 1,2; Gucer, P. 1,2; Wilson, P. D. 3; Kane, R. 2,4; Cernich, A. 2,4; Kaup, B. 2,4; Anderson, L. 5; Hoover, D. 5; Brown, L. 2,6; Albertini, R. 7; Gudi, R. 8; Jacobson-Kram, D. 9; Squibb, K. S. 2,3; Affiliations: 1: Department of Medicine, University of Maryland, School of Medicine, Baltimore; 2: Department of Veterans Affairs Medical Center, Baltimore; 3: Department of Epidemiology and Preventive Medicine, University of Maryland, School of Medicine, Baltimore; 4: Department of Psychiatry, University of Maryland, School of Medicine, Baltimore; 5: Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore; 6: Department of Pathology, University of Maryland, School of Medicine, Baltimore; 7: Department of Pathology, University of Vermont; 8: Bioreliance, Rockville, MD; 9: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD; Issue Info: Jul2007, Vol. 93 Issue 1, p60; Thesaurus Term: HEALTH; Thesaurus Term: Depleted uranium; Thesaurus Term: Health risk assessment; Thesaurus Term: Genetic toxicology; Subject Term: Veterans; Subject Term: Friendly fire (Military science); Subject Term: Persian Gulf War, 1991; Subject Term: Urinalysis; Subject Term: Fluorescence in situ hybridization; Author-Supplied Keyword: cumulative; Author-Supplied Keyword: depleted; Author-Supplied Keyword: excretion; Author-Supplied Keyword: exposure; Author-Supplied Keyword: health effects; Author-Supplied Keyword: uranium; Author-Supplied Keyword: urinary; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Josephs, J. S.
AU - Fleishman, J. A.
AU - Gaist, P.
AU - Gebo, K. A.
T1 - Use of complementary and alternative medicines among a multistate, multisite cohort of people living with HIV/AIDS.
JO - HIV Medicine
JF - HIV Medicine
Y1 - 2007/07//
VL - 8
IS - 5
M3 - Article
SP - 300
EP - 305
PB - Wiley-Blackwell
SN - 14642662
AB - Objective The aim of the study was to assess the prevalence of and factors associated with use of complementary or alternative medicine (CAM) in a multistate, multisite cohort of HIV-infected patients. Methods During 2003, 951 adult patients from 14 sites participated in face-to-face interviews. Patients were asked if they received treatment from any alternative therapist or practitioner in the previous 6 months. Logistic regression was performed to examine associations between demographic and clinical variables and CAM use. Results The majority of the participants were male (68%) and African American (52%) with a median age of 45 years (range 20–85 years). Sixteen per cent used any CAM in the 6 months prior to the interview. Factors associated with use of CAM were the HIV risk factor injecting drug use [adjusted odds ratio (AOR) 0.51] compared with men who have sex with men (MSM), former drug use (AOR=2.12) compared with never having used drugs, having a college education (AOR=2.43), and visiting a mental health provider (AOR=2.76). Conclusions This study demonstrated similar rates of CAM use in the current highly active antiretroviral therapy (HAART) era compared with the pre-HAART era. Factors associated with CAM – such as education, use of mental health services, and MSM risk factor – suggest that CAM use may be associated with heightened awareness regarding the availability of such therapies. Given the potential detrimental interactions of certain types of CAM and HAART, all HIV-infected patients should be screened for use of CAM. [ABSTRACT FROM AUTHOR]
AB - Copyright of HIV Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - HIV-positive persons
KW - LOGISTIC regression analysis
KW - MEDICAL personnel & patient
KW - MENTAL health
KW - HIV infections -- Treatment
KW - alternative therapy
KW - complementary therapy
KW - highly active antiretroviral therapy
KW - HIV Research Network
KW - illicit drug use
N1 - Accession Number: 25317090; Josephs, J. S. 1 Fleishman, J. A. 2 Gaist, P. 3 Gebo, K. A. 1; Email Address: kgebo@jhmi.edu; Affiliation: 1: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 2: Agency for Healthcare Research and Quality, Rockville, MD 3: National Institutes of Health, Bethesda, MD, USA; Source Info: Jul2007, Vol. 8 Issue 5, p300; Subject Term: ALTERNATIVE medicine; Subject Term: HIV-positive persons; Subject Term: LOGISTIC regression analysis; Subject Term: MEDICAL personnel & patient; Subject Term: MENTAL health; Subject Term: HIV infections -- Treatment; Author-Supplied Keyword: alternative therapy; Author-Supplied Keyword: complementary therapy; Author-Supplied Keyword: highly active antiretroviral therapy; Author-Supplied Keyword: HIV Research Network; Author-Supplied Keyword: illicit drug use; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1468-1293.2007.00474.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sammarco, John J.
T1 - Programmable Electronic and Hardwired Emergency Shutdown Systems: A Quantified Safety Analysis.
JO - IEEE Transactions on Industry Applications
JF - IEEE Transactions on Industry Applications
Y1 - 2007/07//Jul/Aug2007
VL - 43
IS - 4
M3 - Article
SP - 1061
EP - 1068
SN - 00939994
AB - Emergency shutdown systems (ESDs) for mining machinery provide critical functions to safeguard miners. Traditionally, ESDs were realized with simple hardwired circuits; today, there is a growing trend to use programmable electronic technology such as programmable logic controllers (PLCs). This paper describes an analytical study to quantify the safety integrity of a PLC-based ESD and a hardwired ESD. The safety integrity level (SW) of each design approach was determined by quantifying the average probability of failure on demand (PFDavg) as described by the recommendations for programmable electronic mining systems published by the National Institute for Occupational Safety and Health and the IEC 61508 international standard. The safety analyses addressed system architecture, hardware failure probability, proof test interval, diagnostic coverage, and human error probability. The results indicated that a same level of safety, SIL 3, could be attained when evaluating random hardware failures. Neither approach could attain SIL 3 if manual activation was used. Human error was the limiting factor where, using human reliability analysis, PFDavg < 1 × 10-1; thus, the ESD does not meet SIL 1. It is apparent that automatic verses human-activation of the ESD is a very important safety consideration. Manually actuated ESDs can only achieve SIL 1 regardless of the technology; therefore, additional independent safety layers of protection are needed to exceed SIL 1. Second, it is apparent that the technology choice is very important. The PLC-based ESD was much simpler to design and to validate safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Industry Applications is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINE safety -- Equipment & supplies
KW - MINING machinery
KW - ELECTRIC circuits
KW - MINERS -- Safety measures
KW - PROGRAMMABLE logic devices
KW - PROGRAMMABLE controllers
KW - HUMAN error
KW - INDUSTRIAL safety
KW - Electronics
KW - emergency shutdown systems (ESDs)
KW - mining safety
KW - programmable electronics (PE)
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 26111075; Sammarco, John J. 1; Email Address: Jsammarco@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh, PA 15236 USA.; Source Info: Jul/Aug2007, Vol. 43 Issue 4, p1061; Subject Term: MINE safety -- Equipment & supplies; Subject Term: MINING machinery; Subject Term: ELECTRIC circuits; Subject Term: MINERS -- Safety measures; Subject Term: PROGRAMMABLE logic devices; Subject Term: PROGRAMMABLE controllers; Subject Term: HUMAN error; Subject Term: INDUSTRIAL safety; Author-Supplied Keyword: Electronics; Author-Supplied Keyword: emergency shutdown systems (ESDs); Author-Supplied Keyword: mining safety; Author-Supplied Keyword: programmable electronics (PE); Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 333131 Mining Machinery and Equipment Manufacturing; NAICS/Industry Codes: 417220 Mining and oil and gas well machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 333130 Mining and oil and gas field machinery manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1109/TIA.2007.900477
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The Effect of Phase Cancellation on Estimates of Calcaneal Broadband Ultrasound Attenuation in Vivo.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2007/07//
VL - 54
IS - 7
M3 - Article
SP - 1352
EP - 1359
SN - 08853010
AB - Broadband ultrasonic attenuation (BUA) is a clinically-accepted measurement for prediction of osteoporotic fracture risk. Typical clinical BUA measurements are performed with phase-sensitive receivers and, therefore, can be affected by phase cancellation. In order to separate the effects of conventional attenuation (absorption plus scattering) from phase cancellation, BUA was measured on phantoms with acrylic wedge phase aberrators and on 73 women using both phase sensitive (PS) and phase insensitive (PI) reception. A clinical bone sonometer with a two-dimensional (2-D) receiver array was used. PI BUA measurements on phantoms with acrylic wedge phase aberrators were found to be far more resistant to phase cancellation than PS BUA measurements. In data from 73 women, means and standard deviations for BUA measurements were 81.4 ± 21.4 dB/MHZ (PS) and 67.2 ± 9.7 dB/MHz (PI). The magnitude of the discrepancy between PS BUA and PI BUA tended to increase with bone mineral density (BMD). [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC waves -- Attenuation
KW - HEEL bone fractures
KW - BONES -- Wounds & injuries
KW - IMAGING systems in medicine
KW - DIAGNOSTIC imaging
N1 - Accession Number: 25772252; Wear, Keith A. 1; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: U. S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852; Source Info: Jul2007, Vol. 54 Issue 7, p1352; Subject Term: ULTRASONIC waves -- Attenuation; Subject Term: HEEL bone fractures; Subject Term: BONES -- Wounds & injuries; Subject Term: IMAGING systems in medicine; Subject Term: DIAGNOSTIC imaging; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 8p; Document Type: Article
L3 - 10 .1109/TUFFC.2007.395
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nagata, Hisao
AU - Ohno, Hisato
T1 - Analysis of Backward Falls Caused by Accelerated Floor Movements Using a Dummy.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/07//
VL - 45
IS - 3
M3 - Article
SP - 462
EP - 466
SN - 00198366
AB - The article presents an analysis of backward falls caused by accelerated floor movements with the use of a standing dummy on slippery and non-slippery surface. The study revealed that the head impact velocity are at 22 to 23 km/h and the duration of falling was 0.83 s when standing on slippery surface and 0.98 s on non-slippery surface. Furthermore, it was also claimed that the duration of falling was at 0.8 s as the maximum velocity of accelerated movements of the floor increased.
KW - Falls (Accidents)
KW - Floors
KW - Body movement
KW - Speed
KW - Dummy board figures
KW - Falls
KW - Floor acceleration
KW - Floor slipperiness
KW - Head impact velocity
KW - Leg joints
KW - Standing dummy
N1 - Accession Number: 27138745; Nagata, Hisao 1; Ohno, Hisato 2; Affiliations: 1: National Institute of Occupational Safety and Health, 1-4-6 Umezono, Kiyose, Tokyo 204-0024, Japan; 2: Railway Technical Research Institute, Japan; Issue Info: 2007, Vol. 45 Issue 3, p462; Subject Term: Falls (Accidents); Subject Term: Floors; Subject Term: Body movement; Subject Term: Speed; Subject Term: Dummy board figures; Author-Supplied Keyword: Falls; Author-Supplied Keyword: Floor acceleration; Author-Supplied Keyword: Floor slipperiness; Author-Supplied Keyword: Head impact velocity; Author-Supplied Keyword: Leg joints; Author-Supplied Keyword: Standing dummy; Number of Pages: 5p; Illustrations: 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Daum, Luke T.
AU - Canas, Linda C.
AU - Arulanandam, Bernard P.
AU - Niemeyer, Debra
AU - Valdes, James J.
AU - Chambers, James P.
T1 - Real-time RT-PCR assays for type and subtype detection of influenza A and B viruses.
JO - Influenza & Other Respiratory Viruses
JF - Influenza & Other Respiratory Viruses
Y1 - 2007/07//
VL - 1
IS - 4
M3 - Article
SP - 167
EP - 175
SN - 17502640
AB - Influenza viruses type A (H3N2 and H1N1 subtypes) and B are the most prevalently circulating human influenza viruses. However, an increase in several confirmed cases of high pathogenic H5N1 in humans has raised concerns of a potential pandemic underscoring the need for rapid, point of contact detection. In this report, we describe development and evaluation of ‘type,’ i.e., influenza virus A and B, and ‘subtype,’ i.e., H1, H3, and H5, specific, single-step/reaction vessel format, real-time RT-PCR assays using total RNA from archived reference strains, shell-vial cultured and uncultured primary (throat swab/nasal wash) clinical samples. The type A and B specific assays detected all 16 influenza type A viruses and both currently circulating influenza B lineages (Yamagata and Victoria), respectively. ‘Type’ and ‘subtype’ specific assays utilize one common set of thermocycling conditions, are specific and highly sensitive (detection threshold of approximately 100 target template molecules). All clinical specimens and samples were evaluated using both the unconventional portable Ruggedized Advanced Pathogen Identification Device (RAPID) and standard laboratory bench LightCycler instruments. These potentially field-deployable assays could offer significant utility for rapid, point of care screening needs arising from a pandemic influenza outbreak. [ABSTRACT FROM AUTHOR]
AB - Copyright of Influenza & Other Respiratory Viruses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA viruses
KW - REVERSE transcriptase
KW - POLYMERASE chain reaction
KW - ASSAYING
KW - INFLUENZA
KW - PANDEMICS
KW - H1
KW - H3
KW - H5
KW - influenza A/B
KW - RT-PCR
N1 - Accession Number: 27355966; Daum, Luke T. 1,2 Canas, Linda C. 3 Arulanandam, Bernard P. 1,2 Niemeyer, Debra 4 Valdes, James J. 5 Chambers, James P. 1,2; Email Address: James.chambers@utsa.edu; Affiliation: 1: Department of Biology, The University of Texas, San Antonio, San Antonio, TX, USA 2: The Center of Excellence in Biotechnology, Bioprocessing, Education, and Research, Brooks City Base, TX, USA 3: Air Force Institute for Operational Health, Brooks City Base, TX, USA 4: Office of the Surgeon General (USAF), Pentagon, Army Navy Drive and Fern Street, Arlington, VA, USA 5: Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, USA; Source Info: Jul2007, Vol. 1 Issue 4, p167; Subject Term: INFLUENZA viruses; Subject Term: REVERSE transcriptase; Subject Term: POLYMERASE chain reaction; Subject Term: ASSAYING; Subject Term: INFLUENZA; Subject Term: PANDEMICS; Author-Supplied Keyword: H1; Author-Supplied Keyword: H3; Author-Supplied Keyword: H5; Author-Supplied Keyword: influenza A/B; Author-Supplied Keyword: RT-PCR; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1750-2659.2007.00024.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Machuca, Ana
AU - Shixing Tang
AU - Jinjie Hu
AU - Lee, Sherwin
AU - Wood, Owen
AU - Vockley, Christopher
AU - Vutukuri, Suresh Gupta
AU - Deshmukh, Ranjana
AU - Awazi, Bih
AU - Hewlett, Indira
T1 - Increased Genetic Diversity and Intersubtype Recombinants of HIV-1 in Blood Donors From Urban Cameroon.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2007/07//7/1/2007
VL - 45
IS - 3
M3 - Article
SP - 361
EP - 363
SN - 15254135
AB - The article discusses a study on the increase of genetic diversity and intersubtype recombinants of HIV-1 in blood donors from Cameroon. The variation of HIV-1 in a population within a limited geographic area suggests the future complexity of the HIV epidemic worldwide. It is important to continually monitor current HIV assays for sensitivity for HIV variants.
KW - BLOOD donors
KW - HIV-positive persons
KW - GENETICS
KW - EPIDEMICS
KW - CAMEROON
N1 - Accession Number: 25976167; Machuca, Ana 1 Shixing Tang 1 Jinjie Hu 1 Lee, Sherwin 1 Wood, Owen 1 Vockley, Christopher 1 Vutukuri, Suresh Gupta 2 Deshmukh, Ranjana 2 Awazi, Bih 3 Hewlett, Indira 1; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologies Evaluation and Research, US Food and Drug Administration, Bethesda, MD 2: Haffkine Institute, Mumbai, India 3: Mobile Laboratory, Sanitation and Hygiene Administration of Health, Laboratoire de Santé, Hygiène Mobile, Yaounde, Cameroon; Source Info: 7/1/2007, Vol. 45 Issue 3, p361; Subject Term: BLOOD donors; Subject Term: HIV-positive persons; Subject Term: GENETICS; Subject Term: EPIDEMICS; Subject Term: CAMEROON; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Douglas L.
AU - Whitaker, Thomas B.
AU - Simonson, Janet
AU - Morris, Hershel F.
AU - Durr, Bobby
AU - Njapau, Henry
T1 - Determining the Variability Associated with Testing Shelled Corn for Aflatoxin Using Different Analytical Procedures in Louisiana in 1998.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/07//Jul/Aug2007
VL - 90
IS - 4
M3 - Article
SP - 1036
EP - 1041
PB - AOAC International
SN - 10603271
AB - The article determines the variability associated with testing shelled corn for aflatoxin using different analytical methods in Louisiana in 1998. The authors measure the differences in aflatoxin test results between elevator laboratories and the Louisiana Agricultural Chemistry laboratory and the total variability associated with testing shelled corn for aflatoxin. They also divide the total variance into combined sampling and subsampling variance and analytical variance.
KW - AFLATOXINS
KW - CORN
KW - AGRICULTURAL chemistry
KW - ANALYSIS of variance
KW - LOUISIANA
N1 - Accession Number: 26097981; Park, Douglas L. 1 Whitaker, Thomas B. 2; Email Address: tom_whitaker@ncsu.edu Simonson, Janet 3 Morris, Hershel F. 3 Durr, Bobby 3 Njapau, Henry 4; Affiliation: 1: Louisiana State University Agricultural Center, Department of Food Science, Baton Rouge, LA 70803 2: U.S. Department of Agriculture/Agricultural Research Service, North Carolina State University, Raleigh, NC 27695 3: Louisiana Department of Agriculture and Forestry, Agricultural Chemistry Division, Baton Rouge, LA 70894 4: Division of Natural Products, Office of Plant and Dairy Food, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740; Source Info: Jul/Aug2007, Vol. 90 Issue 4, p1036; Subject Term: AFLATOXINS; Subject Term: CORN; Subject Term: AGRICULTURAL chemistry; Subject Term: ANALYSIS of variance; Subject Term: LOUISIANA; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111150 Corn Farming; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, Mary W.
AU - Weaver, Carol M.
AU - Oles, Carolyn J.
AU - Rump, Lydia V.
AU - White, Kevin D.
AU - Betz, Joseph M.
AU - Rader, Jeanne I.
T1 - Use of Multitoxin Immunoaffinity Columns for Determination of Aflatoxins and Ochratoxin A in Ginseng and Ginger.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/07//Jul/Aug2007
VL - 90
IS - 4
M3 - Article
SP - 1042
EP - 1049
PB - AOAC International
SN - 10603271
AB - The article determines aflatoxin and ochratoxin A (OTA) in ginseng and ginger using multitoxin immunoaffinity columns. Aflatoxins were separated by reversed-phase liquid chromatography (LC) with fluorescence detection after postcolumn ultraviolet photochemical derivatization. The identities of the toxins in extracts of the finished products were confirmed using LC/tandem mass spectrometry with multiple-reaction monitoring of three colliosionally induced product ions from OTA and aflatoxins.
KW - AFLATOXINS
KW - OCHRATOXINS
KW - GINSENG
KW - GINGER
KW - LIQUID chromatography
KW - FLUORESCENCE
KW - PHOTOCHEMISTRY
KW - MASS spectrometry
N1 - Accession Number: 26097982; Trucksess, Mary W. 1; Email Address: mary.trucksess@fda.hhs.gov Weaver, Carol M. 1 Oles, Carolyn J. 1 Rump, Lydia V. 1 White, Kevin D. 1 Betz, Joseph M. 2 Rader, Jeanne I. 1; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740 2: National Institutes of Health, Office of Dietary Supplements, Bethesda, MD 20892; Source Info: Jul/Aug2007, Vol. 90 Issue 4, p1042; Subject Term: AFLATOXINS; Subject Term: OCHRATOXINS; Subject Term: GINSENG; Subject Term: GINGER; Subject Term: LIQUID chromatography; Subject Term: FLUORESCENCE; Subject Term: PHOTOCHEMISTRY; Subject Term: MASS spectrometry; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; Number of Pages: 8p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whitaker, Thomas B.
AU - Doko, M. Bruno
AU - Maestroni, Britt M.
AU - Slate, Andrew B.
AU - Ogunbanwo, Bosede F.
T1 - Evaluating the Performance of Sampling Plans to Detect Fumonisin Bi in Maize Lots Marketed in Nigeria.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/07//Jul/Aug2007
VL - 90
IS - 4
M3 - Article
SP - 1050
EP - 1059
PB - AOAC International
SN - 10603271
AB - The article evaluates the performance of sampling plans to detect fumonisin in maize produced and marketed in Nigeria. The performance was also evaluated to show how to manipulate sample size and accept/reject limits to reduce misclassification of maize lots. Regression equations were developed to determine the total variance as a function of fumonisin concentration. The variance and distribution information was used to develop a computer model to predict to detect fumonisin in maize shipments.
KW - SAMPLING (Statistics)
KW - FUMONISINS
KW - CORN
KW - REGRESSION analysis
KW - NIGERIA
N1 - Accession Number: 26097983; Whitaker, Thomas B. 1; Email Address: tom_whitaker@ncsu.edu Doko, M. Bruno 2 Maestroni, Britt M. 2 Slate, Andrew B. 3 Ogunbanwo, Bosede F. 4; Affiliation: 1: U.S. Department of Agriculture, Agricultural Research Service, Box 7625, North Carolina State University, Raleigh, NC 27695-7625 2: International Atomic Energy Agency (IAEA), Agrochemicals Unit, IAEA/FAO Biotechnology Laboratories, Agency's Laboratories, Seibersdorf, Austria 3: North Carolina State University, Biological and Agricultural Engineering Department, Box 7625, Raleigh, NC 27695-7625 4: National Agency for Food and Drug Administration and Control, Mycotoxin Unit, Oshodi Central Laboratories, Lagos, Nigeria; Source Info: Jul/Aug2007, Vol. 90 Issue 4, p1050; Subject Term: SAMPLING (Statistics); Subject Term: FUMONISINS; Subject Term: CORN; Subject Term: REGRESSION analysis; Subject Term: NIGERIA; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 10p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whitaker, Thomas B.
AU - Saltsman, Joyce J.
AU - Ware, George M.
AU - Slate, Andrew B.
T1 - Evaluating the Performance of Sampling Plans to Detect Hypoglycin A in Ackee Fruit Shipments Imported into the United States.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/07//Jul/Aug2007
VL - 90
IS - 4
M3 - Article
SP - 1060
EP - 1072
PB - AOAC International
SN - 10603271
AB - The article analyzes the performance of sampling plans to detect hypoglycin A (HGA) in ackee fruit shipments imported into the U.S. The authors divide the total variance associated with the HGA test procedure into sampling, sample preparation and analytical variance components. They also utilize the variability and distributional information to create a computer model to predict the buyers' and sellers' risks associated with any given sampling plan design.
KW - SAMPLING (Statistics)
KW - HYPOGLYCIN A
KW - AKEE
KW - FRUIT
KW - UNITED States
N1 - Accession Number: 26097984; Whitaker, Thomas B. 1; Email Address: Tom_Whitaker@ncsu.edu Saltsman, Joyce J. 2 Ware, George M. 3 Slate, Andrew B. 4; Affiliation: 1: U.S. Department of Agriculture, Agricultural Research Service, Box 7625, North Carolina State University, Raleigh, NC 27695-7625 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Safety, 5100 Paint Branch Pkwy, College Park, MD 20740-3835 3: U.S. Food and Drug Administration, 60 8th St, NE, Atlanta, GA 30309 4: North Carolina State University, Biological and Agricultural Engineering Department, Box 7625, Raleigh, NC 27695-7625; Source Info: Jul/Aug2007, Vol. 90 Issue 4, p1060; Subject Term: SAMPLING (Statistics); Subject Term: HYPOGLYCIN A; Subject Term: AKEE; Subject Term: FRUIT; Subject Term: UNITED States; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 13p; Illustrations: 1 Black and White Photograph, 4 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kweon, Ohgew
AU - Seong-Jae Kim
AU - Jones, Richard C.
AU - Freeman, James P.
AU - Adjei, Michael D.
AU - Edmondson, Ricky D.
AU - Cerniglia, Carl E.
T1 - A Polyomic Approach To Elucidate the Fluoranthene-Degradative Pathway in Mycobacterium vanbaalenii PYR-1.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2007/07//
VL - 189
IS - 13
M3 - Article
SP - 27
EP - 27
SN - 00219193
AB - Mycobacterium vanbaalenii PYR-1 is capable of degrading a wide range of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs), including fluoranthene. We used a combination of metabolomic, genomic, and proteomic technologies to investigate fluoranthene degradation in this strain. Thirty-seven fluoranthene metabolites including potential isomers were isolated from the culture medium and analyzed by high-performance liquid chromatography, gas chromatography-mass spectrometry, and UV-visible absorption. Total proteins were separated by one-dimensional gel and analyzed by liquid chromatography-tandem mass spectrometry in conjunction with the M. vanbaalenii PYR-1 genome sequence (http://jgi.doe.gov), which resulted in the identification of 1,122 proteins. Among them, 53 enzymes were determined to be likely involved in fluoranthene degradation. We integrated the metabolic information with the genomic and proteomic results and proposed pathways for the degradation of fluoranthene. According to our hypothesis, the oxidation of fluoranthene is initiated by dioxygenation at the C-1,2, C-2,3, and C-7,8 positions. The C-1,2 and C-2,3 dioxygenation routes degrade fluoranthene via fluorene-type metabolites, whereas the C-7,8 routes oxidize fluoranthene via acenaphthylene-type metabolites. The major site of dioxygenation is the C-2,3 dioxygenation route, which consists of 18 enzymatic steps via 9-fluorenone-1-carboxylic acid and phthalate with the initial ring-hydroxylating oxygenase, NidA3B3, oxidizing fluoranthene to fluoranthene cis-2,3-dihydrodiol. Nonspecific monooxygenation of fluoranthene with subsequent O methylation of dihydroxyfluoranthene also occurs as a detoxification reaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM
KW - POLYCYCLIC aromatic hydrocarbons
KW - BIODEGRADATION
KW - PROTEINS
KW - OXIDATION
KW - METABOLIC detoxification
N1 - Accession Number: 25831071; Kweon, Ohgew 1 Seong-Jae Kim 1 Jones, Richard C. 2 Freeman, James P. 3 Adjei, Michael D. 1,4 Edmondson, Ricky D. 2 Cerniglia, Carl E. 1; Email Address: carl.cerniglia@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079 2: Division of Systems Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079 3: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 720793 4: Norfolk Department of Public Health, 830 Southampton Ave., Norfolk, VA 23510; Source Info: Jul2007, Vol. 189 Issue 13, p27; Subject Term: MYCOBACTERIUM; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: BIODEGRADATION; Subject Term: PROTEINS; Subject Term: OXIDATION; Subject Term: METABOLIC detoxification; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.00128-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ku, Bon Ki
AU - Maynard, Andrew D.
AU - Baron, Paul A.
AU - Deye, Gregory J.
T1 - Observation and measurement of anomalous responses in a differential mobility analyzer caused by ultrafine fibrous carbon aerosols
JO - Journal of Electrostatics
JF - Journal of Electrostatics
Y1 - 2007/07//
VL - 65
IS - 8
M3 - Article
SP - 542
EP - 548
SN - 03043886
AB - Abstract: We observed anomalous instrument responses above certain voltages when characterizing aggregates of airborne carbon nanotubes or nanofibers using a differential mobility analyzer (DMA). These were associated with sudden increases in measured number concentrations at high voltages, fluctuations in DMA voltage and audible high-frequency sounds from the DMA column. Onset of the anomalies depended on the material forming the aerosol and DMA sampling flow rate. The low density of the nanotubes relative to the nanofibers is thought to be the main reason the anomalous responses occur more easily and strongly with the nanotubes. Two possible mechanisms are suggested to explain the observations. The results indicate that measurement of nanometer-diameter conducting fibrous material by electrical mobility analysis may present a unique challenge. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electrostatics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - CARBON nanotubes
KW - HIGH voltages
KW - ELECTRIC fields
KW - Arcing
KW - Carbon nanotube/nanofiber
KW - Differential mobility analyzer
KW - Electrical discharge
KW - Low density
N1 - Accession Number: 24787285; Ku, Bon Ki; Email Address: BKu@cdc.gov Maynard, Andrew D. Baron, Paul A. 1 Deye, Gregory J. 1; Affiliation: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA; Source Info: Jul2007, Vol. 65 Issue 8, p542; Subject Term: AEROSOLS (Sprays); Subject Term: CARBON nanotubes; Subject Term: HIGH voltages; Subject Term: ELECTRIC fields; Author-Supplied Keyword: Arcing; Author-Supplied Keyword: Carbon nanotube/nanofiber; Author-Supplied Keyword: Differential mobility analyzer; Author-Supplied Keyword: Electrical discharge; Author-Supplied Keyword: Low density; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.elstat.2006.10.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steven J. Page
AU - Donald P. Tuchman
AU - Robert P. Vinson
T1 - Thermally induced filter bias in TEOM mass measurement.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2007/07//
VL - 9
IS - 7
M3 - Article
SP - 760
EP - 767
SN - 14640325
AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) have long used stationary tapered element oscillating microbalances (TEOMs®) in laboratory settings. They have served to assess the mass concentration of laboratory-generated particulates in experimental dust chambers and they provide a reference method for comparison with other particulate-measuring instruments. Current NIOSH research is focused on further adapting TEOM technology as a wearable personal dust monitor (PDM) for coal mining occupations. This investigation’s goal is to help identify, quantify, and provide means for resolving certain TEOM-related error. The present research investigated bias caused by thermal effects on filter assemblies. New filters used in the PDM for 8 h tests show an average positive bias of 25.5 μg, while similar tests of equivalent filters used in two 1400A model TEOMs show an average positive bias of 34.3 μg. The derived bias values allow correction of previously collected biased data. Also, pre-heating the filters for 24 h at 46 °C shows significant bias reduction, with PDM pre-heated filters subsequently averaging −3.3 μg and 1400A TEOM filters averaging 5.9 μg. On a single-point comparison to gravimetric sampling, a 25.5 μg bias is only significant at low mass loadings. At 2.5 mg, this bias represents a negligible 1% of the mass measurement. If ordinary linear regression is used, the bias is still insignificant. However, if the more valid weighted linear regression is used, it gives more weight to the smaller dependent variable values, which are more impacted by the bias. Consequently, what is 1% bias on a single high-mass value can translate into a larger bias percentage at high-mass values when performing a weighted regression on data that include a large number of low-mass values. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Mass (Physics) -- Measurement
KW - Dust -- Measurement
KW - Thermal analysis
N1 - Accession Number: 25594965; Steven J. Page 1; Donald P. Tuchman 1; Robert P. Vinson 1; Affiliations: 1: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research LaboratoryP.O. Box 18070, 626 Cochrans Mill Road Pittsburgh, PA USA; Issue Info: Jul2007, Vol. 9 Issue 7, p760; Thesaurus Term: Air pollution; Subject Term: Mass (Physics) -- Measurement; Subject Term: Dust -- Measurement; Subject Term: Thermal analysis; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chan, Po-Chuen
AU - Xia, Qingsu
AU - Fu, Peter P.
T1 - Ginkgo Biloba Leave Extract: Biological, Medicinal, and Toxicological Effects.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2007/07//Jul-Sep2007
VL - 25
IS - 3
M3 - Article
SP - 211
EP - 244
SN - 10590501
AB - Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti-inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits. It exerts allergy and changes in bleeding time. While its mutagenicity or carcinogenic activity has not been reported, its components, quercetin, kaempferol and rutin have been shown to be genotoxic. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leave extract nor are exposure limits imposed. Safety evaluation of Ginkgo biloba leave extract is being conducted by the U.S. National Toxicology Program. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental research
KW - Toxicology
KW - Dietary supplements
KW - Gymnosperms
KW - Ginkgo
KW - Quercetin
KW - biological and toxicological effects
KW - Gingko Biloba leave extract
KW - ginkgolidc
KW - quercetin
N1 - Accession Number: 26461438; Chan, Po-Chuen 1; Xia, Qingsu 2; Fu, Peter P. 2; Affiliations: 1: National Institute of Environmental Health Sciences, Research Triangle Park, NC; 2: National Center for Toxicological Research, Jefferson, AR; Issue Info: Jul-Sep2007, Vol. 25 Issue 3, p211; Thesaurus Term: Environmental research; Thesaurus Term: Toxicology; Thesaurus Term: Dietary supplements; Thesaurus Term: Gymnosperms; Subject Term: Ginkgo; Subject Term: Quercetin; Author-Supplied Keyword: biological and toxicological effects; Author-Supplied Keyword: Gingko Biloba leave extract; Author-Supplied Keyword: ginkgolidc; Author-Supplied Keyword: quercetin; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 34p; Illustrations: 3 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1080/10590500701569414
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - De Martinis, Elaine Cristina Pereira
AU - Duvall, Robert E.
AU - Hitchins, Anthony D.
T1 - Real-Time PCR Detection of 16S rRNA Genes Speeds Most-Probable-Number Enumeration of Foodborne Listeria monocytogenes.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/07//
VL - 70
IS - 7
M3 - Article
SP - 1650
EP - 1655
SN - 0362028X
AB - Quantifying foodborne pathogens at concentrations of 0.1 to 1,000 CFU/g of food generally involves most-probable-number (MPN) enumeration, which takes at least 4 days. A real-time PCR assay (RTi-PCR) was developed to accelerate MPN enumeration of foodborne Listeria monocytogenes. Foods were spiked from 70 to 110 CFU/g, and triplicate subportions from 0.0001 to 1 g were selectively enriched for 48 h at 30°C. For standard MPN enumeration, the enrichments were subcultured on Oxford agar (48 h at 35°C) to isolate Listeria. For RTi-PCR MPN, the L. monocytogenes cells from the same enrichments were washed and resuspended in 2 ml of sterile water. DNA was extracted by boiling for 10 min. The DNA in the extract's supernatant was targeted with published oligonucleotide primers for amplifying an Lmo-specific sequence of 16S rRNA genes. Amplification was continuously monitored with SYBR Green. The resulting amplicon was characterized by its melting temperature. The L. monocytogenes specificity of the primers was confirmed by testing L. monocytogenes (15 strains), Listeria innocua (11 strains), and Listeria welshimeri, Listeria seeligeri, Listeria ivanovii, and Listeria grayi (1 strain each). Quantitatively spiked milk, lettuce, smoked salmon, Brie cheese, ice cream, pork pâté, salami, ready-to-eat shrimp, raw ground beef, and fresh soft cheese were enumerated by both the standard and the PCR MPN method. The paired results from the two MPN methods agreed well, except for the fresh cheese. For some foods, 1-g samples required a decimal dilution for a positive test result, suggesting concentration-dependent food ingredient interference with the RTi-PCR. This RTi-PCR method reduced the time necessary for the MPN enumeration of foodborne L. monocytogenes from 4 to 2 days. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Communicable diseases
KW - Gram-positive bacteria
KW - Pathogenic microorganisms
KW - Listeria monocytogenes
N1 - Accession Number: 25999476; De Martinis, Elaine Cristina Pereira 1; Duvall, Robert E. 2; Hitchins, Anthony D. 2; Email Address: anthony.hitchins@fda.hhs.gov; Affiliations: 1: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Monte Alegre, 14040-903 Ribeirão Preto, SP, Brazil; 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA; Issue Info: Jul2007, Vol. 70 Issue 7, p1650; Thesaurus Term: Foodborne diseases; Thesaurus Term: Communicable diseases; Thesaurus Term: Gram-positive bacteria; Thesaurus Term: Pathogenic microorganisms; Subject Term: Listeria monocytogenes; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - O'Brien, Katherine L.
AU - Moïsi, Jennifer
AU - Moulton, Lawrence H.
AU - Madore, Dace
AU - Eick, Angelia
AU - Reid, Ray
AU - Weatherholtz, Robert
AU - Millar, Eugene
AU - Hu, Diana
AU - Hackell, Jill
AU - Kohberger, Robert
AU - Siber, George
AU - Santosham, Mathuram
T1 - Predictors of Pneumococcal Conjugate Vaccine Immunogenicity among Infants and Toddlers in an American Indian PnCRM7 Efficacy Trial.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/07//7/1/2007
VL - 196
IS - 1
M3 - Article
SP - 104
EP - 114
SN - 00221899
AB - Background. Pneumococcal conjugate vaccines are important for the prevention of serious illness and death among infants. Factors associated with pneumococcal conjugate vaccine immunogenicity have not been explored. Methods. Children <24 months of age received 2, 3, or 4 doses of 7-valent pneumococcal conjugate vaccine (PnCRM7) or control vaccine depending on age at enrollment. Serum samples were tested for serotype-specific antibodies by enzyme-linked immunosorbant assay. Multiple linear regression was used to determine predictors of immunogenicity.Results. Among 315 PnCRM7-vaccinated subjects and 295 control subjects enrolled at <7 months of age, geometric mean concentrations (GMCs) of antibodies were significantly higher after dose 3 than after dose 2 for all serotypes except type 4. The proportion of subjects with antibody concentrations ⩾5.0 mg/mL was higher for all serotypes, but the proportion with concentrations ⩾0.35 mg/mL was higher only for types 6B and 23F. Threedose and 2-dose regimens for those 7–11 and 12–23 months of age, respectively, were highly immunogenic. Increased maternal antibody concentrations were associated with reduced responses to dose 1 and 3 but not to dose 4 of PnCRM7. Conclusions. Maternal antibody is associated with a reduced infant response to PnCRM7 but does not interfere with immune memory. In infants, a third priming dose increases the antibody GMC and the proportion achieving an antibody concentration ⩾5.0 mg/mL but has little impact on the proportion achieving a concentration ⩾0.35 mg/mL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PNEUMOCOCCAL vaccine
KW - INFANTS
KW - TODDLERS
KW - IMMUNOGLOBULINS
KW - SERUM
KW - IMMUNOLOGIC memory
N1 - Accession Number: 25368354; O'Brien, Katherine L. 1; Email Address: klobrien@jhsph.edu Moïsi, Jennifer 2 Moulton, Lawrence H. 2 Madore, Dace 3 Eick, Angelia 1 Reid, Ray 1 Weatherholtz, Robert 1 Millar, Eugene 1 Hu, Diana 4 Hackell, Jill 3 Kohberger, Robert 3 Siber, George 3 Santosham, Mathuram 1; Affiliation: 1: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 2: Department of International Health and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 3: Wyeth Vaccines, Pearl River, New York 4: Indian Health Service, Department of Health and Human Services, Tuba City, Arizona; Source Info: 7/1/2007, Vol. 196 Issue 1, p104; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: INFANTS; Subject Term: TODDLERS; Subject Term: IMMUNOGLOBULINS; Subject Term: SERUM; Subject Term: IMMUNOLOGIC memory; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1086/518438
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cashdollar, Kenneth L.
AU - Zlochower, Isaac A.
T1 - Explosion temperatures and pressures of metals and other elemental dust clouds
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2007/07//
VL - 20
IS - 4-6
M3 - Article
SP - 337
EP - 348
SN - 09504230
AB - Abstract: The Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH) conducted a study of the explosibility of various metals and other elemental dusts, with a focus on the experimental explosion temperatures. The data are useful for understanding the basics of dust cloud combustion, as well as for evaluating explosion hazards in the minerals and metals processing industries. The dusts studied included boron, carbon, magnesium, aluminum, silicon, sulfur, titanium, chromium, iron, nickel, copper, zinc, niobium, molybdenum, tin, hafnium, tantalum, tungsten, and lead. The dusts were chosen to cover a wide range of physical properties—from the more volatile materials such as magnesium, aluminum, sulfur, and zinc to the highly “refractory” elements such as carbon, niobium, molybdenum, tantalum, and tungsten. These flammability studies were conducted in a 20-L chamber, using strong pyrotechnic ignitors. A unique multiwavelength infrared pyrometer was used to measure the temperatures. For the elemental dusts studied, all ignited and burned as air-dispersed dust clouds except for nickel, copper, molybdenum, and lead. The measured maximum explosion temperatures ranged from ∼1550K for tin and tungsten powders to ∼2800K for aluminum, magnesium, and titanium powders. The measured temperatures are compared to the calculated, adiabatic flame temperatures. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXPLOSIONS
KW - ALUMINUM
KW - METALLURGY
KW - MOLYBDENUM
KW - Dust
KW - Explosion
KW - Metal
KW - Temperature
N1 - Accession Number: 26488015; Cashdollar, Kenneth L.; Email Address: KCashdollar@cdc.gov; Zlochower, Isaac A. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Jul2007, Vol. 20 Issue 4-6, p337; Subject Term: EXPLOSIONS; Subject Term: ALUMINUM; Subject Term: METALLURGY; Subject Term: MOLYBDENUM; Author-Supplied Keyword: Dust; Author-Supplied Keyword: Explosion; Author-Supplied Keyword: Metal; Author-Supplied Keyword: Temperature; NAICS/Industry Codes: 331317 Aluminum rolling, drawing, extruding and alloying; NAICS/Industry Codes: 331318 Other Aluminum Rolling, Drawing, and Extruding; NAICS/Industry Codes: 331314 Secondary Smelting and Alloying of Aluminum; NAICS/Industry Codes: 331313 Alumina Refining and Primary Aluminum Production; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.jlp.2007.04.018
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Otsuka, Teruhito
AU - Saitoh, Hiroyasu
AU - Mizutani, Takaaki
AU - Morimoto, Kaoru
AU - Yoshikawa, Norihiko
T1 - Hazard evaluation of hydrogen–air deflagration with flame propagation velocity measurement by image velocimetry using brightness subtraction
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2007/07//
VL - 20
IS - 4-6
M3 - Article
SP - 427
EP - 432
SN - 09504230
AB - Abstract: Deflagration phenomena in hydrogen–air mixtures initially filled in 1.4m3 spherical latex balloons were measured using a high-speed digital video camera and pressure transducers. The image velocimetry using brightness subtraction was introduced to eliminate the background effects for obtaining accurate time evolution records of flame propagation velocity. The maximum flame propagation velocity of about 100m/s was observed with maximum overpressure 15kPa at 1m from ignition point. According to the detailed flame propagation velocity records, there were long deceleration durations. The observed maximum overpressure was smaller than the overpressure estimated by the basis of the observed maximum flame propagation velocity and the pressure wave theories of spherical flames. A new blast curve plot of scaled overpressure vs. distance was tentatively proposed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR reactions
KW - PARTICLES (Nuclear physics)
KW - VELOCIMETRY
KW - SPEED
KW - Blast curve
KW - Deflagration
KW - Hydrogen
KW - Image velocimetry
KW - Scaling law
N1 - Accession Number: 26488024; Otsuka, Teruhito 1; Email Address: ohtsuka@s.jniosh.go.jp; Saitoh, Hiroyasu 2; Mizutani, Takaaki 1; Morimoto, Kaoru 2; Yoshikawa, Norihiko 2; Affiliations: 1: National Institute of Occupational Safety and Health (JNIOSH), 1-4-6 Umezono, Kiyose, Tokyo 204-0024, Japan; 2: Department of Micro-nano Systems Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan; Issue Info: Jul2007, Vol. 20 Issue 4-6, p427; Subject Term: NUCLEAR reactions; Subject Term: PARTICLES (Nuclear physics); Subject Term: VELOCIMETRY; Subject Term: SPEED; Author-Supplied Keyword: Blast curve; Author-Supplied Keyword: Deflagration; Author-Supplied Keyword: Hydrogen; Author-Supplied Keyword: Image velocimetry; Author-Supplied Keyword: Scaling law; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jlp.2007.04.031
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Cashdollar, Kenneth L.
AU - Weiss, Eric S.
AU - Montgomery, Terry G.
AU - Going, John E.
T1 - Post-explosion observations of experimental mine and laboratory coal dust explosions
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2007/07//
VL - 20
IS - 4-6
M3 - Article
SP - 607
EP - 615
SN - 09504230
AB - Abstract: The Pittsburgh Research Laboratory (PRL) of the National Institute for Occupational Safety and Health (NIOSH) and the Mine Safety and Health Administration (MSHA) conducted joint research on dust explosions by studying post-explosion dust samples. The samples were collected after full-scale explosions at the PRL Lake Lynn Experimental Mine (LLEM), and after laboratory explosions in the PRL 20-L chamber and the Fike 1m3 chamber. The dusts studied included both high- and low-volatile bituminous coals. Low temperature ashing for 24h at 515°C was used to measure the incombustible content of the dust before and after the explosions. The data showed that the post-explosion incombustible content was always as high as, or higher than the initial incombustible content. The MSHA alcohol coking test was used to determine the amount of coked dust in the post-explosion samples. The results showed that almost all coal dust that was suspended within the explosion flame produced significant amounts of coke. Measurements of floor dust concentrations after LLEM explosions were compared with the initial dust loadings to determine the transport distance of dust during an explosion. All these data will be useful in future forensic investigations of accidental dust explosions in coal mines, or elsewhere. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINE safety
KW - HEALTH services administration
KW - DUST explosions
KW - Dust
KW - Explosion
KW - Mine explosion
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 26488049; Cashdollar, Kenneth L. 1; Email Address: KCashdollar@cdc.gov; Weiss, Eric S. 1; Montgomery, Terry G. 2; Going, John E. 3; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA; 2: Mine Safety and Health Administration, Mt. Hope, WV 25880, USA; 3: Fike Corporation, Blue Springs, MO 64015, USA; Issue Info: Jul2007, Vol. 20 Issue 4-6, p607; Thesaurus Term: MINE safety; Thesaurus Term: HEALTH services administration; Subject Term: DUST explosions; Author-Supplied Keyword: Dust; Author-Supplied Keyword: Explosion; Author-Supplied Keyword: Mine explosion ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jlp.2007.04.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=26488049&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sapko, Michael J.
AU - Cashdollar, Kenneth L.
AU - Green, Gregory M.
T1 - Coal dust particle size survey of US mines
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2007/07//
VL - 20
IS - 4-6
M3 - Article
SP - 616
EP - 620
SN - 09504230
AB - Abstract: The National Institute for Occupational Safety and Health (NIOSH) and the Mine Safety and Health Administration (MSHA) conducted a joint survey to determine the range of coal particle sizes found in dust samples collected from intake airways of US coal mines. The last comprehensive survey of this type was performed in the 1920s. The size of the coal dust is relevant to the amount of rock dust required to inert the coal dust, with more rock dust needed to inert finer sizes of coal dust. Dust samples were collected by MSHA inspectors from several mines in each of MSHA''s 10 bituminous Coal Mine Safety and Health Districts. Samples were normally collected in several intakes at each mine. The laboratory analysis procedures included acid leaching of the sample to remove the limestone rock dust, sonic sieving to determine the dust size, and low-temperature ashing of the sieved fractions to correct for any remaining incombustible matter. The results indicate that particle sizes of mine coal dust in intake airways are finer than those measured in the 1920s. This finer size coal dust in intake airways would require more incombustible matter to be effectively inerted than the 65% incombustible specified in current regulations. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINE safety
KW - HEALTH services administration
KW - COAL mines & mining
KW - Coal
KW - Dust
KW - Explosion
KW - Mine
KW - Particle size
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 26488050; Sapko, Michael J. 1; Cashdollar, Kenneth L.; Email Address: KCashdollar@cdc.gov; Green, Gregory M. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA, USA; Issue Info: Jul2007, Vol. 20 Issue 4-6, p616; Thesaurus Term: MINE safety; Thesaurus Term: HEALTH services administration; Thesaurus Term: COAL mines & mining; Author-Supplied Keyword: Coal; Author-Supplied Keyword: Dust; Author-Supplied Keyword: Explosion; Author-Supplied Keyword: Mine; Author-Supplied Keyword: Particle size ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jlp.2007.04.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=26488050&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Mizutani, Takaaki
AU - Miyake, Atsumi
AU - Matsui, Hidenori
T1 - Decomposing deflagration properties of acetylene under low temperatures
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2007/07//
VL - 20
IS - 4-6
M3 - Article
SP - 688
EP - 690
SN - 09504230
AB - Abstract: In this study, the decomposing deflagration properties of acetylene under temperatures down to −60°C and pressures up to 0.2MPa in a 1-L cylindrical closed vessel were experimentally investigated. The gases were ignited by an electric spark at the center of the vessel. The lower-limit pressures of decomposing deflagration by electric spark ignition were determined. The lower-limit pressure at 10°C was 0.15MPa, and it gradually increased with decreasing temperature. The lower-limit pressure at −60oC was 0.18MPa. The flame propagation properties, such as the pressure, were measured with pressure transducers mounted along the vessel. The maximum decomposing deflagration pressures and pressure rising rates also increased with decreasing temperature. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETYLENE
KW - ELECTRIC spark
KW - PRESSURE -- Measurement
KW - PRESSURE transducers
KW - Acetylene
KW - Decomposing deflagrations
KW - Low temperature
N1 - Accession Number: 26488057; Mizutani, Takaaki 1; Email Address: mizutani@anken.go.jp; Miyake, Atsumi 2; Matsui, Hidenori 3; Affiliations: 1: Chemical Safety Research Group, Institute of Industrial Safety, National Institute of Occupational Safety and Health, Tokyo, Japan; 2: Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Yokohama, Japan; 3: Technology Support Division, Technology Institution of Industrial Safety, Saitama, Japan; Issue Info: Jul2007, Vol. 20 Issue 4-6, p688; Subject Term: ACETYLENE; Subject Term: ELECTRIC spark; Subject Term: PRESSURE -- Measurement; Subject Term: PRESSURE transducers; Author-Supplied Keyword: Acetylene; Author-Supplied Keyword: Decomposing deflagrations; Author-Supplied Keyword: Low temperature; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jlp.2007.04.040
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Schubauer-Berigan, Mary K.
AU - Deddens, James A.
AU - Petersen, Martin R.
T1 - Re: Exposure to Beryllium and Occurrence of Lung Cancer: A Reexamination of Findings From a Nested Case-Control Study.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/07//
VL - 49
IS - 7
M3 - Letter
SP - 708
EP - 709
SN - 10762752
AB - A letter to the editor is presented in response to the article "Exposure to Beryllium and Occurrence of Lung Cancer: A Reexamination of Findings From a Nested Case-Control Study" published in the previous issue.
KW - LETTERS to the editor
KW - LUNGS -- Cancer
N1 - Accession Number: 25823906; Schubauer-Berigan, Mary K. 1 Deddens, James A. 1 Petersen, Martin R. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, OH; Source Info: Jul2007, Vol. 49 Issue 7, p708; Subject Term: LETTERS to the editor; Subject Term: LUNGS -- Cancer; Number of Pages: 2p; Document Type: Letter
L3 - 10.1097/JOM.0b013e3180d09e9c
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, E. J.
AU - Taggart, B.
AU - Crandell, S.
AU - Lasky, R. E.
AU - Williams, A. L.
AU - Love, L. J.
AU - Sexton, J. B.
AU - Tyson, J. E.
AU - Helmreich, R. L.
T1 - Teaching teamwork during the Neonatal Resuscitation Program: a randomized trial.
JO - Journal of Perinatology
JF - Journal of Perinatology
Y1 - 2007/07//
VL - 27
IS - 7
M3 - Article
SP - 409
EP - 414
SN - 07438346
AB - Objective:To add a team training and human error curriculum to the Neonatal Resuscitation Program (NRP) and measure its effect on teamwork. We hypothesized that teams that received the new course would exhibit more teamwork behaviors than those in the standard NRP course.Study design:Interns were randomized to receive NRP with team training or standard NRP, then video recorded when they performed simulated resuscitations at the end of the day-long course. Outcomes were assessed by observers blinded to study arm allocation and included the frequency or duration of six team behaviors: inquiry, information sharing, assertion, evaluation of plans, workload management and vigilance.Result:The interns in the NRP with team training group exhibited more frequent team behaviors (number of episodes per minute (95% CI)) than interns in the control group: information sharing 1.06 (0.24, 1.17) vs 0.13 (0.00, 0.43); inquiry 0.35 (0.11, 0.42) vs 0.09 (0.00, 0.10); assertion 1.80 (1.21, 2.25) vs 0.64 (0.26, 0.91); and any team behavior 3.34 (2.26, 4.11) vs 1.03 (0.48, 1.30) (P-values <0.008 for all comparisons). Vigilance and workload management were practiced throughout the entire simulated code by nearly all the teams in the NRP with team training group (100% for vigilance and 88% for workload management) vs only 53 and 20% of the teams in the standard NRP. No difference was detected in the frequency of evaluation of plans.Conclusion:Compared with the standard NRP, NRP with a teamwork and human error curriculum led interns to exhibit more team behaviors during simulated resuscitations.Journal of Perinatology (2007) 27, 409–414; doi:10.1038/sj.jp.7211771; published online 7 June 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Perinatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEAMS in the workplace
KW - RESUSCITATION
KW - NEWBORN infants
KW - HUMAN error
KW - INTERNS (Medicine)
KW - PERINATOLOGY
KW - neonatal resuscitation
KW - patient safety
KW - team training
KW - teamwork
N1 - Accession Number: 25522095; Thomas, E. J. 1,2; Email Address: Eric.Thomas@uth.tmc.edu Taggart, B. 1,3 Crandell, S. 1,4 Lasky, R. E. 1,4 Williams, A. L. 4 Love, L. J. 4 Sexton, J. B. 1,5,6 Tyson, J. E. 1,4 Helmreich, R. L. 1,3; Affiliation: 1: University of Texas Center of Excellence for Patient Safety Research and Practice (Agency for Healthcare Research and Quality grant #1PO1HS1154401), Houston, TX, USA 2: Division of General Medicine, Department of Medicine, University of Texas Houston Medical School, Houston, TX, USA 3: Department of Psychology, University of Texas, Austin, Human Factors Research Project, Austin, TX, USA 4: Department of Pediatrics, University of Texas Houston Medical School, Austin, TX, USA 5: Department of Anesthesiology and Critical Care, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, MD, USA 6: Department of Health Policy and Management, Johns Hopkins University Schools of Medicine and Public Health, Baltimare, MD, USA; Source Info: Jul2007, Vol. 27 Issue 7, p409; Subject Term: TEAMS in the workplace; Subject Term: RESUSCITATION; Subject Term: NEWBORN infants; Subject Term: HUMAN error; Subject Term: INTERNS (Medicine); Subject Term: PERINATOLOGY; Author-Supplied Keyword: neonatal resuscitation; Author-Supplied Keyword: patient safety; Author-Supplied Keyword: team training; Author-Supplied Keyword: teamwork; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/sj.jp.7211771
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zongming Gao
AU - Moore, Terry W.
AU - Smith, Anjanette P.
AU - Doub, William H.
AU - Westenberger, Benjamin J.
T1 - Studies of variability in dissolution testing with USP apparatus 2.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/07//
VL - 96
IS - 7
M3 - Article
SP - 1794
EP - 1801
SN - 00223549
AB - In this study, gauge repeatability and reproducibility (gauge R&R) was used to analyze variability for USP apparatus 2 dissolution measurement systems. Experiments were designed to assess the variability due to apparatus, operator, and sample tablet. Since dissolution testing is a destructive test, a nested model was used for data analysis. Additionally, perturbation tests with both disintegrating and nondisintegrating tablets were performed to study the variability due to sample position within the dissolution vessel. For the gauge R&R study, two well-trained chemists used two mechanically calibrated USP apparatus 2 units. Six tests were performed by each operator on each apparatus. Evaluation of dissolution test results at 30 min using an internal DPA calibrator tablet NCDA#2 (10 mg prednisone) indicates that the main contribution to the total variance, approximately 70%, is due to the sample tablets, approximately 25% is from the apparatus and approximately 5% is due to the operators. There is no significant difference between operators and apparatuses as shown by the gauge R&R studies. In addition, dissolution results can be strongly affected by the position of the tablet within the vessel. Similarity (f1) and dissimilarity (f2) factors were calculated to statistically evaluate differences between perturbed and normal dissolution tests. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1794–1801, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Solubility -- Testing
KW - TABLETS (Medicine)
KW - SOLID dosage forms
KW - PREDNISONE
KW - ANALYSIS of variance
KW - STATISTICAL hypothesis testing
KW - dissolution test
KW - dissolution test; gauge R½R; variability; f1 and f2 factors
KW - gauge R&R
KW - variability
N1 - Accession Number: 25354151; Zongming Gao 1; Email Address: zongming.gao@fda.hhs.gov Moore, Terry W. 1 Smith, Anjanette P. 1 Doub, William H. 1 Westenberger, Benjamin J. 1; Affiliation: 1: Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, Missouri 63101; Source Info: Jul2007, Vol. 96 Issue 7, p1794; Subject Term: DRUGS -- Solubility -- Testing; Subject Term: TABLETS (Medicine); Subject Term: SOLID dosage forms; Subject Term: PREDNISONE; Subject Term: ANALYSIS of variance; Subject Term: STATISTICAL hypothesis testing; Author-Supplied Keyword: dissolution test; Author-Supplied Keyword: dissolution test; gauge R½R; variability; f1 and f2 factors; Author-Supplied Keyword: gauge R&R; Author-Supplied Keyword: variability; Number of Pages: 8p; Illustrations: 2 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1002/jps.20839
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25354151&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The dependence of time-domain speed-of-sound measurements on center frequency, bandwidth, and transit-time marker in human calcaneus in vitro.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2007/07//
VL - 122
IS - 1
M3 - Article
SP - 636
EP - 644
SN - 00014966
AB - Time-domain speed-of-sound (SOS) measurements in calcaneus are effective predictors of osteoporotic fracture risk. High attenuation and dispersion in bone, however, produce severe distortion of transmitted pulses that leads to ambiguity of time-domain SOS measurements. An equation to predict the effects of system parameters (center frequency and bandwidth), algorithm parameters (pulse arrival-time marker), and bone properties (attenuation coefficient and thickness) on time-domain SOS estimates is derived for media with attenuation that varies linearly with frequency. The equation is validated using data from a bone-mimicking phantom and from 30 human calcaneus samples in vitro. The data suggest that the effects of dispersion are small compared with the effects of frequency-dependent attenuation. The equation can be used to retroactively compensate data. System-related variations in SOS are shown to decrease as the pulse-arrival-time marker is moved toward the pulse center. Therefore, compared with other time-domain measures of SOS, group velocity exhibits the minimum system dependence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEEL bone
KW - SPEED of sound
KW - TIME-domain analysis
KW - BANDWIDTHS
KW - ALGORITHMS
KW - EQUATIONS
N1 - Accession Number: 25638764; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-140, 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Jul2007, Vol. 122 Issue 1, p636; Subject Term: HEEL bone; Subject Term: SPEED of sound; Subject Term: TIME-domain analysis; Subject Term: BANDWIDTHS; Subject Term: ALGORITHMS; Subject Term: EQUATIONS; Number of Pages: 9p; Illustrations: 5 Charts, 10 Graphs; Document Type: Article
L3 - 10.1121/1.2735811
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Keep Kids Active In and Out of School
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2007/07//
VL - 107
IS - 7
M3 - Editorial
SP - 1089
EP - 1089
SN - 00028223
N1 - Accession Number: 25568689; Moritsugu, Kenneth P. 1; Affiliation: 1: Acting US Surgeon General, US Department of Health and Human Services; Source Info: Jul2007, Vol. 107 Issue 7, p1089; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2007.05.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106196903
T1 - Keep kids active in and out of school.
AU - Moritsugu KP
Y1 - 2007/07//
N1 - Accession Number: 106196903. Language: English. Entry Date: 20071123. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition; Pediatric Care. NLM UID: 7503061.
KW - Health Promotion -- In Infancy and Childhood
KW - Physical Activity -- In Infancy and Childhood
KW - Pediatric Obesity -- Prevention and Control
KW - Adolescence
KW - Child
KW - Dietitians
KW - Information Resources
KW - Schools
KW - World Wide Web
SP - 1089
EP - 1089
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 107
IS - 7
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Acting US Surgeon General, US Department of Health and Human Services.
U2 - PMID: 17604731.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Humphreys, Betsy L.
T1 - Building better connections: the National Library of Medicine and public health.
JO - Journal of the Medical Library Association
JF - Journal of the Medical Library Association
Y1 - 2007/07//
VL - 95
IS - 3
M3 - Article
SP - 293
EP - 300
PB - Medical Library Association
SN - 15365050
AB - Purpose: The paper describes the expansion of the public health programs and services of the National Library of Medicine (NLM) in the 1990s and provides the context in which NLM's public health outreach programs arose and exist today. Brief Description: Although NLM has always had collections and services relevant to public health, the US public health workforce made relatively little use of the library's information services and programs in the twentieth century. In the 1990s, intensified emphases on outreach to health professionals, building national information infrastructure, and promoting health data standards provided NLM with new opportunities to reach the public health community. A seminal conference cosponsored by NLM in 1995 produced an agenda for improving public health access to and use of advanced information technology and electronic information services. NLM actively pursued this agenda by developing new services and outreach programs and promoting public health informatics initiatives. Method: Historical analysis is presented. Results/Outcome: NLM took advantage of a propitious environment to increase visibility and understanding of public health information challenges and opportunities. The library helped create partnerships that produced new information services, outreach initiatives, informatics innovations, and health data policies that benefit the public health workforce and the diverse populations it serves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Medical Library Association is the property of Medical Library Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health administration
KW - OUTREACH programs
KW - PUBLIC health -- Computer network resources
KW - INTELLECTUAL cooperation
KW - LIBRARY cooperation
KW - INFORMATION science
KW - PUBLIC health personnel -- Education
KW - LIBRARIES & education
KW - GOVERNMENT libraries
KW - UNITED States
KW - NATIONAL Library of Medicine (U.S.)
N1 - Accession Number: 26019304; Humphreys, Betsy L. 1; Email Address: Betsy.Humphreys@nih.hhs.gov; Affiliation: 1: Deputy Director, National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894; Source Info: Jul2007, Vol. 95 Issue 3, p293; Subject Term: PUBLIC health administration; Subject Term: OUTREACH programs; Subject Term: PUBLIC health -- Computer network resources; Subject Term: INTELLECTUAL cooperation; Subject Term: LIBRARY cooperation; Subject Term: INFORMATION science; Subject Term: PUBLIC health personnel -- Education; Subject Term: LIBRARIES & education; Subject Term: GOVERNMENT libraries; Subject Term: UNITED States; Company/Entity: NATIONAL Library of Medicine (U.S.); NAICS/Industry Codes: 519120 Libraries and Archives; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105835190
T1 - Building better connections: the National Library of Medicine and public health.
AU - Humphreys BL
Y1 - 2007/07//
N1 - Accession Number: 105835190. Language: English. Entry Date: 20090102. Revision Date: 20150820. Publication Type: Journal Article; research. Journal Subset: Computer/Information Science; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101132728.
KW - National Library of Medicine (U.S.) -- Administration
KW - Public Health
KW - Community-Institutional Relations
KW - Cooperative Behavior
KW - Data Collection -- Standards
KW - Health Education -- Administration
KW - Health Policy
KW - History
KW - Libraries, Electronic -- Administration
KW - National Library of Medicine (U.S.) -- History
KW - United States
KW - Human
SP - 293
EP - 300
JO - Journal of the Medical Library Association
JF - Journal of the Medical Library Association
JA - J MED LIBR ASSOC
VL - 95
IS - 3
CY - Carol Stream, Illinois
PB - Medical Library Association
AB - Purpose: The paper describes the expansion of the public health programs and services of the National Library of Medicine (NLM) in the 1990s and provides the context in which NLM's public health outreach programs arose and exist today.Brief Description: Although NLM has always had collections and services relevant to public health, the US public health workforce made relatively little use of the library's information services and programs in the twentieth century. In the 1990s, intensified emphases on outreach to health professionals, building national information infrastructure, and promoting health data standards provided NLM with new opportunities to reach the public health community. A seminal conference cosponsored by NLM in 1995 produced an agenda for improving public health access to and use of advanced information technology and electronic information services. NLM actively pursued this agenda by developing new services and outreach programs and promoting public health informatics initiatives.Method: Historical analysis is presented.Results/Outcome: NLM took advantage of a propitious environment to increase visibility and understanding of public health information challenges and opportunities. The library helped create partnerships that produced new information services, outreach initiatives, informatics innovations, and health data policies that benefit the public health workforce and the diverse populations it serves.
SN - 1536-5050
AD - Betsy.Humphreys@nih.hhs.gov , Deputy Director, National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894.
U2 - PMID: 17641764.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105835190&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shih-Houng Young
AU - Ostroff, Gary R.
AU - Zeidler-Erdely, Patti C.
AU - Roberts, Jenny R.
AU - Antonini, James M.
AU - Castranova, Vincent
T1 - A Comparison of the Pulmonary Inflammatory Potential of Different Components of Yeast Cell Wall.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/07//
VL - 70
IS - 13
M3 - Article
SP - 1116
EP - 1124
SN - 15287394
AB - 1→3-β-Glucan has been associated with pulmonary inflammation induced by exposure to fungal or yeast cell wall dust. 1→3-β-Glucan is the major cell wall component of yeast or fungi. However, the yeast cell wall contains several other components besides 1→3-β-glucans, such as mannan and chitin. Few studies evaluated the contribution of these other cell wall components to pulmonary inflammation. The present study compares a crude particulate yeast cell wall preparation (zymosan A) to purified yeast glucan, purified yeast glucan mannan, or purified yeast glucan chitin particles for their potency to induce mouse pulmonary inflammation after in vivo exposure. Mannan is the second most abundant polysaccharide in the yeast cell wall, whereas chitin content is a minor component. The results show that pulmonary injury is mediated by both chitin and 1→3-β-glucan and to a lesser degree by mannan. There is also evidence that zymosan is more potent than purified 1→3-β-glucan alone. Evidence indicates that 1→3-β-glucan is the major inflammatory component in yeast and fungal cell walls. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCANS
KW - YEAST fungi
KW - PNEUMONIA
KW - INFLAMMATION
KW - LUNG diseases
KW - POLYSACCHARIDES
KW - CHITIN
KW - FUNGAL cell walls
KW - MICE as laboratory animals
KW - PATHOLOGY
N1 - Accession Number: 25346979; Shih-Houng Young 1; Email Address: sby5@cdc.gov Ostroff, Gary R. 2 Zeidler-Erdely, Patti C. 1 Roberts, Jenny R. 1 Antonini, James M. 1 Castranova, Vincent 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health. Morgantown, West Virginia, USA 2: University of Massachusetts Medical School. Worcester, Massachusetts, USA; Source Info: Jul2007, Vol. 70 Issue 13, p1116; Subject Term: GLUCANS; Subject Term: YEAST fungi; Subject Term: PNEUMONIA; Subject Term: INFLAMMATION; Subject Term: LUNG diseases; Subject Term: POLYSACCHARIDES; Subject Term: CHITIN; Subject Term: FUNGAL cell walls; Subject Term: MICE as laboratory animals; Subject Term: PATHOLOGY; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Color Photograph, 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/15287390701212224
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106144141
T1 - Global self-rated mental health: associations with other mental health measures and with role functioning.
AU - Fleishman JA
AU - Zuvekas SH
Y1 - 2007/07//2007 Jul
N1 - Accession Number: 106144141. Language: English. Entry Date: 20070831. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Instrumentation: Short Form 12 Health Survey (SF-12); Patient Health Questionnaire (PHQ-2). Grant Information: Agency for Healthcare Research and Quality, Rockville, MD. NLM UID: 0230027.
KW - Mental Status -- Evaluation
KW - Self Concept
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Factor Analysis
KW - Female
KW - Functional Status
KW - Funding Source
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Pearson's Correlation Coefficient
KW - Regression
KW - Research Instruments
KW - Self Report
KW - Human
SP - 602
EP - 609
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND:: A large body of research shows that global self-rated health is related to important outcome variables. Increasingly, studies also obtain a single global self-rating of mental health, but understanding of what this item measures is limited. OBJECTIVE:: To clarify interpretation of self-reported mental health, we examine its associations with other validated measures of mental health and role functioning. RESEARCH DESIGN:: We conducted cross-sectional analyses of nationally representative data from the Medical Expenditure Panel Survey. MEASURES:: In-person household interviews obtained data on global self-reported mental health and any limitations in work, school, or housekeeping activities. Adult respondents (N = 11,109) completed the SF-12 health status survey, the K6 scale of nonspecific psychologic distress, and the Patient Health Questionnaire (PHQ-2) depression screener in a self-administered questionnaire. We used the SF-12 Mental Component Summary and the mental health subscale. Analyses examined associations among mental health measures and regressed activity limitations, and the SF-12 physical and emotional role functioning scales on mental health measures, controlling for demographics and selected chronic conditions. RESULTS:: The 4 multi-item mental health measures were strongly correlated with each other (r > 0.69), but correlated less strongly with the self-reported mental health item (r approximately 0.4). In an exploratory factor analysis, self-reported mental health loaded on both mental and physical health factors. In multivariate analyses, each mental health variable was significantly associated with activity limitations and with role functioning, but the association of self-reported mental health with emotional role functioning was relatively weak. CONCLUSIONS:: Although global self-rated mental health is related to symptoms of psychologic distress, it cannot be considered to be a substitute for them.
SN - 0025-7079
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 17571008.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cave, Kara M.
AU - Cornish, Elizabeth M.
AU - Chandler, David W.
T1 - Blast Injury of the Ear: Clinical Update from the Global War on Terror.
JO - Military Medicine
JF - Military Medicine
Y1 - 2007/07//
VL - 172
IS - 7
M3 - Article
SP - 726
EP - 730
PB - AMSUS
SN - 00264075
AB - The purpose of this study was to describe the effects of blast exposure on hearing status. This study retrospectively analyzed hearing thresholds and otologic complaints for >250 patients with blast-related injuries from the global war on terror. Of patients who received full diagnostic evaluations, 32% reported a history of tympanic membrane perforation, 49% experienced tinnitus, 26% reported otalgia (ear pain), and 15% reported dizziness. Expected hearing thresholds were computed by applying age-correction factors to hearing tests performed earlier in the service members' careers and before their most recent deployment. Expected hearing thresholds were significantly better than actual postdeployment thresholds, indicating that significant changes occurred in the patients' hearing that could not be accounted for by age. Results from this study underline the need for documentation of pre-and postdeployment hearing tests and prompt otologic evaluation for the blast-exposed population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - HEARING disorders
KW - TINNITUS
KW - NEUROLOGIC manifestations of general diseases
KW - DEPLOYMENT (Military strategy)
KW - COUNTERTERRORISM
N1 - Accession Number: 25805909; Cave, Kara M. 1 Cornish, Elizabeth M. 2 Chandler, David W. 3; Affiliation: 1: Army Research Laboratory, Human Research and Engineering Directorate, Aberdeen Proving Ground, MD 21005 2: Department of Audiology, Madigan Army Medical Center, Tacoma, WA 98431 3: Office of the Surgeon General, Falls Church, VA 22041; Source Info: Jul2007, Vol. 172 Issue 7, p726; Subject Term: RESEARCH; Subject Term: HEARING disorders; Subject Term: TINNITUS; Subject Term: NEUROLOGIC manifestations of general diseases; Subject Term: DEPLOYMENT (Military strategy); Subject Term: COUNTERTERRORISM; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sardy, Marin
T1 - DAYCARE AFFECTS CHILDREN'S BEHAVIOR.
JO - Mothering
JF - Mothering
Y1 - 2007/07//Jul/Aug2007
IS - 143
M3 - Article
SP - 34
EP - 34
PB - Mothering Publishing Inc.
SN - 07333013
AB - The article highlights the results of a study conducted by the U.S. National Institutes of Health on the association of child care programs with children's later patterns of disruptive behavior.
KW - CHILD care services
KW - BEHAVIOR disorders in children
N1 - Accession Number: 25614835; Sardy, Marin 1; Source Information: Jul/Aug2007, Issue 143, p34; Subject: CHILD care services; Subject: BEHAVIOR disorders in children; Number of Pages: 1/2p; Document Type: Article; Full Text Word Count: 268
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DP - EBSCOhost
DB - hxh
ER -
TY - JOUR
AU - Darrah, Patricia A.
AU - Patel, Dipti T.
AU - De Luca, Paula M.
AU - Lindsay, Ross W. B.
AU - Davey, Dylan F.
AU - Flynn, Barbara J.
AU - Hoff, Søren T.
AU - Andersen, Peter
AU - Reed, Steven G.
AU - Morris, Sheldon L.
AU - Roederer, Mario
AU - Seder, Robert A.
T1 - Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.
JO - Nature Medicine
JF - Nature Medicine
Y1 - 2007/07//
VL - 13
IS - 7
M3 - Article
SP - 843
EP - 850
PB - Nature Publishing Group
SN - 10788956
AB - CD4+ T cells have a crucial role in mediating protection against a variety of pathogens through production of specific cytokines. However, substantial heterogeneity in CD4+ T-cell cytokine responses has limited the ability to define an immune correlate of protection after vaccination. Here, using multiparameter flow cytometry to assess the immune responses after immunization, we show that the degree of protection against Leishmania major infection in mice is predicted by the frequency of CD4+ T cells simultaneously producing interferon-γ, interleukin-2 and tumor necrosis factor. Notably, multifunctional effector cells generated by all vaccines tested are unique in their capacity to produce high amounts of interferon-γ. These data show that the quality of a CD4+ T-cell cytokine response can be a crucial determinant in whether a vaccine is protective, and may provide a new and useful prospective immune correlate of protection for vaccines based on T-helper type 1 (TH1) cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Medicine is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - PATHOGENIC microorganisms
KW - CYTOKINES
KW - VACCINATION
KW - FLOW cytometry
KW - INTERLEUKIN-2
N1 - Accession Number: 25681920; Darrah, Patricia A. 1 Patel, Dipti T. 1 De Luca, Paula M. 1 Lindsay, Ross W. B. 1 Davey, Dylan F. 1 Flynn, Barbara J. 1 Hoff, Søren T. 2 Andersen, Peter 2 Reed, Steven G. 3 Morris, Sheldon L. 4 Roederer, Mario 5 Seder, Robert A. 1; Email Address: rseder@mail.nih.gov; Affiliation: 1: Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), 40 Convent Drive, Bethesda, Maryland 20892, USA 2: Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK-2300 Copenhagen S, Denmark 3: Infectious Disease Research Institute, 1124 Columbia Street, Seattle, Washington 98104, USA 4: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA 5: ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, 40 Convent Drive, Bethesda, Maryland 20892, USA; Source Info: Jul2007, Vol. 13 Issue 7, p843; Subject Term: T cells; Subject Term: PATHOGENIC microorganisms; Subject Term: CYTOKINES; Subject Term: VACCINATION; Subject Term: FLOW cytometry; Subject Term: INTERLEUKIN-2; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 2 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1038/nm1592
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takahashi, Yukio
AU - Harada, Niriaki
T1 - A CONSIDERATION OF AN EVALUATION INDEX FOR HIGH-LEVEL LOW-FREQUENCY NOISE BY TAKING INTO ACCOUNT THE EFFECT OF HUMAN BODY VIBRATION.
JO - Noise & Vibration Bulletin
JF - Noise & Vibration Bulletin
Y1 - 2007/07//
M3 - Article
SP - 185
EP - 193
SN - 00290974
AB - At high sound pressure levels, actual body vibrations (noise-induced vibrations) are induced by low-frequency noise. The purpose of this trial study was to show that considering the effects of noise-induced vibration is effective in evaluating high-level low-frequency noise. Using the A-weighted sound pressure level and the Wk-weighted vibration acceleration level of noise-induced vibration measured on the chest as independent variables, empirical evaluation indices (HLLF1, HLLF2 and HLLF3) for evaluating the unpleasantness caused by high-level low-frequency noise were estimated. The HLLF indices were found to be able to evaluate the unpleasantness caused by high-level low-frequency noise better than the A-weighted pressure level. In addition, the slopes of tentative frequency-weighting characteristics corresponding to the HLLF indices were estimated to be gentler than that of the Aweighting characteristic within 25-50 Hz, which was consistent with many previous results that indicated that noise content at lower frequencies should be given more importance when evaluating low-frequency noise. Although there are several areas where the HLLF index needs to be improved before it is put in practical use, the results of this study suggest that high-level low-frequency noise could be more effectively evaluated by taking into account the effect of human body vibration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise & Vibration Bulletin is the property of Multi-Science Publishing Co Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOUND pressure
KW - VIBRATION (Mechanics)
KW - NOISE
KW - HUMAN body
KW - EMPIRICAL research
N1 - Accession Number: 27057033; Takahashi, Yukio 1 Harada, Niriaki 2; Affiliation: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, Japan, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan 2: Department of Hygiene, Yamaguchi University Graduate School of Medicine 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan; Source Info: Jul2007, p185; Subject Term: SOUND pressure; Subject Term: VIBRATION (Mechanics); Subject Term: NOISE; Subject Term: HUMAN body; Subject Term: EMPIRICAL research; Number of Pages: 9p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spencer, Ellsworth
AU - Kovalchik, Peter
T1 - Heavy construction equipment noise study using dosimetry and time-motion studies.
JO - Noise Control Engineering Journal
JF - Noise Control Engineering Journal
Y1 - 2007/07//Jul/Aug2007
VL - 55
IS - 4
M3 - Article
SP - 408
EP - 416
PB - Institute of Noise Control Engineering of the USA
SN - 07362501
AB - Noise induced hearing loss continues to afflict workers in many occupational settings despite longstanding recognition of the problems and well-known methods of prevention and regulations. The focus of this research was to determine the noise exposures of heavy construction equipment operators while documenting the workers' tasks, (i.e. hauling, moving, and/or pushing construction material).Time-motion studies were performed at the construction sites and were used to correlate the noise dosage with the work performed by the equipment operators. The cumulative dose for each operator was then plotted with references to work tasks. This was done to identify the tasks that caused the greatest noise exposure. Three construction sites were studied for this research. The types of construction equipment studied included asphalt pavers, backhoes, bulldozers, compaction equipment, excavators, haul trucks, telehandlers, and wheeled loaders. The results indicate that the majority of operators were overexposed to hazardous noise. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Control Engineering Journal is the property of Institute of Noise Control Engineering of the USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Noise-induced deafness
KW - Construction workers -- Safety measures
KW - Time study
KW - Motion study
KW - Heavy construction
KW - Work -- Safety measures
KW - Earthmoving machinery
KW - Excavating machinery
KW - Bulldozers
KW - Backhoes
KW - Construction equipment -- Evaluation
N1 - Accession Number: 26452833; Spencer, Ellsworth 1; Email Address: espencer@cdc.gov; Kovalchik, Peter 1; Email Address: pkovalchik@cdc.gov; Affiliations: 1: National Institute of Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh PA 15236; Issue Info: Jul/Aug2007, Vol. 55 Issue 4, p408; Thesaurus Term: Industrial safety; Subject Term: Noise-induced deafness; Subject Term: Construction workers -- Safety measures; Subject Term: Time study; Subject Term: Motion study; Subject Term: Heavy construction; Subject Term: Work -- Safety measures; Subject Term: Earthmoving machinery; Subject Term: Excavating machinery; Subject Term: Bulldozers; Subject Term: Backhoes; Subject Term: Construction equipment -- Evaluation; NAICS/Industry Codes: 333120 Construction Machinery Manufacturing; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 417210 Construction and forestry machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106141200
T1 - Device safety. On guard for intra-aortic balloon pump problems.
AU - Weil KM
Y1 - 2007/07//
N1 - Accession Number: 106141200. Language: English. Entry Date: 20070824. Revision Date: 20150711. Publication Type: Journal Article; case study; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 7600137.
KW - Equipment Safety
KW - Intra-Aortic Balloon Pumping -- Adverse Effects
KW - Intra-Aortic Balloon Pumping -- Nursing
KW - Critically Ill Patients
KW - Equipment Alarm Systems
KW - Equipment Failure
KW - Inpatients
KW - Monitoring, Physiologic
KW - Time Factors
SP - 28
EP - 28
JO - Nursing
JF - Nursing
JA - NURSING
VL - 37
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-Consultant, Cardiovascular Devices, Center for Devices and Radiological Health
U2 - PMID: 17603351.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sircar, Kanta
AU - Hnizdo, Eva
AU - Petsonk, Edward
AU - Attfield, Michael
T1 - Decline in lung function and mortality: implications for medical monitoring.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2007/07//
VL - 64
IS - 7
M3 - Article
SP - 461
EP - 466
SN - 13510711
AB - Aim: To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEY1). Methods: Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEV1 rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. Results: The risk ratios (compared to ‘below 30 mI/year’) were 1.39 (95% CI 0.99 to 1.97) in the ‘60 to less than 90 mI/year’ category and 1.90 (95% CI 1.32 to 2.76) in the ‘90 ml/year and above’ category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with decreased mortality. Conclusions: Risk of death increases in individuals with rates of decline above about 60 mI/year and is statistically significant with declines of 90 mI/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pulmonary function tests
KW - Mortality -- Statistics
KW - Coal miners
KW - Cohort analysis
KW - Respiratory measurements
KW - Medical care
KW - Smoke prevention
KW - Regression analysis
KW - Surveys
N1 - Accession Number: 25724963; Sircar, Kanta 1; Email Address: KSircar@cdc.gov; Hnizdo, Eva 1; Petsonk, Edward 1; Attfield, Michael 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Jul2007, Vol. 64 Issue 7, p461; Subject Term: Pulmonary function tests; Subject Term: Mortality -- Statistics; Subject Term: Coal miners; Subject Term: Cohort analysis; Subject Term: Respiratory measurements; Subject Term: Medical care; Subject Term: Smoke prevention; Subject Term: Regression analysis; Subject Term: Surveys; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1136/oem.2006031419
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shah, Rakhi B.
AU - Khan, Mansoor A.
T1 - The Evolution of FDA's Role in Ensuring Product Quality.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2007/07//
VL - 31
IS - 7
M3 - Article
SP - 52
EP - 58
PB - Advanstar Communications Inc.
SN - 15432521
AB - The article discusses the role of the Food and Drug Administration (FDA) in product quality and in shaping risk-based approaches to drug development in the U.S. The primary goal of the FDA is the ensure that safe and effective quality drugs are available to public. With its intention of addressing quality issues, the FDA launched its white paper on current good manufacturing practice (CGMP) to highlight challenges in manufacturing processes and end-product quality for drugs and biologics.
KW - STANDARDS
KW - QUALITY of products
KW - CURRENT good manufacturing practices
KW - MANUFACTURING processes
KW - DRUG development
KW - DRUGS
KW - PHARMACEUTICAL policy
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 25685540; Shah, Rakhi B. 1; Khan, Mansoor A. 2; Email Address: mansoor.khan@fda.hhs.gov; Affiliations: 1: Pharmacologist in the US Food and Drug Administration's Division of Product Quality Research at the Center for Drug Evaluation and Research; 2: Director of the same division and a member of Pharmaceutical Technology's editorial advisory board, 10903 New Hampshire Avenue, LS Building 64, Silver Spring, MD 20993-002; Issue Info: Jul2007, Vol. 31 Issue 7, p52; Thesaurus Term: STANDARDS; Thesaurus Term: QUALITY of products; Thesaurus Term: CURRENT good manufacturing practices; Thesaurus Term: MANUFACTURING processes; Subject Term: DRUG development; Subject Term: DRUGS; Subject Term: PHARMACEUTICAL policy; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
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DB - buh
ER -
TY - JOUR
AU - Burwen, Dale R.
AU - La Voie, Lawrence
AU - Braun, M. Miles
AU - Houck, Peter
AU - Ball, Robert
T1 - Evaluating adverse events after vaccination in the Medicare population.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/07//
VL - 16
IS - 7
M3 - Article
SP - 753
EP - 761
SN - 10538569
AB - Purpose Post-licensure observational studies using large linked databases can provide important data about whether adverse events are associated with vaccines, but databases that have been used may not have sufficient statistical power to examine rare events, and may underrepresent the elderly. We assessed the utility of Medicare data for evaluating adverse events after influenza and pneumococcal vaccines, by using an example involving selected clinical conditions, and evaluating aspects of data quality relevant to vaccine safety analyses. Methods We used 2001 data from the National Claims History File and Enrollment Database to determine if hospitalization for urinary tract infection (not likely associated with vaccination) or for cellulitis and abscess of the upper arm and forearm is associated with vaccination. Results For influenza vaccine, the 7-day period after vaccination did not demonstrate an elevation in hospitalization with cellulitis and abscess of the upper arm and forearm; for pneumococcal vaccine, a clear peak was evident. No increase in urinary tract infection was found after either influenza or pneumococcal vaccine. Having a prior Medicare claim for pneumococcal vaccine within 5 years was a risk factor for hospitalization with cellulitis and abscess of the upper arm and forearm (relative risk, 2.6; 95% confidence limits (CL), 1.3, 5.0). Conclusions Medicare data are a useful source for evaluating adverse events after vaccination. Screening analyses can be performed using administrative data, but medical record review to validate diagnoses will often be needed for rigorous study of vaccine-adverse event associations. Published in 2007 by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708173; Burwen, Dale R. 1; La Voie, Lawrence 2; Braun, M. Miles 1; Houck, Peter 3; Ball, Robert 1; Affiliations: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; 2: Kansas City Regional Office, Centers for Medicare & Medicaid Services, Kansas City, MO, USA; 3: Seattle Regional Office, Centers for Medicare & Medicaid Services, Seattle, WA, USA; Issue Info: Jul2007, Vol. 16 Issue 7, p753; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1390
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Killeen, Gerry F.
AU - Smith, Tom A.
AU - Ferguson, Heather M.
AU - Mshinda, Hassan
AU - Abdulla, Salim
AU - Lengeler, Christian
AU - Kachur, Steven P.
T1 - Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2007/07//
VL - 4
IS - 7
M3 - journal article
SP - e229
EP - e229
PB - Public Library of Science
SN - 15491277
AB - Background: Malaria prevention in Africa merits particular attention as the world strives toward a better life for the poorest. Insecticide-treated nets (ITNs) represent a practical means to prevent malaria in Africa, so scaling up coverage to at least 80% of young children and pregnant women by 2010 is integral to the Millennium Development Goals (MDG). Targeting individual protection to vulnerable groups is an accepted priority, but community-level impacts of broader population coverage are largely ignored even though they may be just as important. We therefore estimated coverage thresholds for entire populations at which individual- and community-level protection are equivalent, representing rational targets for ITN coverage beyond vulnerable groups.Methods and Findings: Using field-parameterized malaria transmission models, we show that high (80% use) but exclusively targeted coverage of young children and pregnant women (representing <20% of the population) will deliver limited protection and equity for these vulnerable groups. In contrast, relatively modest coverage (35%-65% use, with this threshold depending on ecological scenario and net quality) of all adults and children, rather than just vulnerable groups, can achieve equitable community-wide benefits equivalent to or greater than personal protection.Conclusions: Coverage of entire populations will be required to accomplish large reductions of the malaria burden in Africa. While coverage of vulnerable groups should still be prioritized, the equitable and communal benefits of wide-scale ITN use by older children and adults should be explicitly promoted and evaluated by national malaria control programmes. ITN use by the majority of entire populations could protect all children in such communities, even those not actually covered by achieving existing personal protection targets of the MDG, Roll Back Malaria Partnership, or the US President's Malaria Initiative. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Medicine is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA
KW - PREGNANT women
KW - INSECTICIDES
KW - CHILDREN
KW - PREGNANCY complications
N1 - Accession Number: 26015629; Killeen, Gerry F. 1,2; Email Address: gkilleen@ihrdc.or.tz Smith, Tom A. 3 Ferguson, Heather M. 1,4,5 Mshinda, Hassan 1 Abdulla, Salim 1 Lengeler, Christian 3 Kachur, Steven P. 1,6; Affiliation: 1: Ifakara Health Research and Development Centre, Ifakara, Morogoro, United Republic of Tanzania 2: Department of Biological and Biomedical Sciences, University of Durham, Durham, United Kingdom 3: Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland 4: Division of Infection and Immunity, Glasgow University, Glasgow, United Kingdom 5: Division of Environmental and Evolutionary Biology, Glasgow University, Glasgow, United Kingdom 6: United States Public Health Service Commissioned Corps and Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America; Source Info: Jul2007, Vol. 4 Issue 7, pe229; Subject Term: MALARIA; Subject Term: PREGNANT women; Subject Term: INSECTICIDES; Subject Term: CHILDREN; Subject Term: PREGNANCY complications; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 1p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: journal article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106170281
T1 - A national survey of state licensing, regulating, and monitoring of residential facilities for children with mental illness.
AU - Teich JL
AU - Ireys HT
Y1 - 2007/07//
N1 - Accession Number: 106170281. Language: English. Entry Date: 20071012. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Grant Information: Contract 282-98-0021 with the Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration. NLM UID: 9502838.
KW - Government Regulations
KW - Licensure
KW - Mental Disorders
KW - Residential Facilities -- Legislation and Jurisprudence -- District of Columbia
KW - Adolescence
KW - Child
KW - Data Collection
KW - Descriptive Statistics
KW - District of Columbia
KW - Funding Source
KW - Government
KW - Length of Stay
KW - Questionnaires
KW - Residential Facilities -- Standards
KW - Surveys
KW - Telephone
KW - United States
KW - Human
SP - 991
EP - 998
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 58
IS - 7
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - OBJECTIVE: Little national information is available to help policy makers understand the methods that states use to regulate residential facilities for children with mental illness. This article describes the results of a government-sponsored survey of state officials that examined how states license, regulate, and monitor such facilities. METHODS: Questionnaires were mailed to selected officials in each of the 50 states and the District of Columbia, followed by extensive telephone and e-mail contacts. Questionnaire items covered program characteristics, licensing and accreditation, mandated services, monitoring and oversight methods, and payment sources. RESULTS: Information was gathered on 71 types of residential facilities in 38 states, accounting for 3,628 separate residential facilities with 50,507 beds as of September 30, 2003. States differed widely in the types of residential facilities that they regulate and their mix of regulatory methods, which included requirements for announced and unannounced visits, mandated staff-to-client ratios, minimum levels of education for facility directors, specifications for licensing practices and critical incident reporting, mandated complaint review procedures, and accreditation from designated organizations. Welfare, mental health, and health departments all participated in regulating facilities. CONCLUSIONS: States relied on at least several regulatory methods, but no state used all of the possible methods. The regulatory environment is complex in most states because several agencies are involved in licensing, regulating, and reviewing complaints. To ensure that residential facilities effectively address the needs of children with mental illness and their families, policy makers should review and improve their state's data on methods for regulating residential facilities.
SN - 1075-2730
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Room 6-1065, Rockville, MD 20857. judith.teich@samhsa.hhs.gov.
U2 - PMID: 17602017.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Siegel, Karen Lohmann
T1 - The Role of the US Public Health Service In Disaster Response.
JO - PT: Magazine of Physical Therapy
JF - PT: Magazine of Physical Therapy
Y1 - 2007/07//
VL - 15
IS - 7
M3 - Letter
SP - 8
EP - 8
PB - American Physical Therapy Association
SN - 10655077
AB - A letter to the editor is presented in response to the April 2007 article "When Disaster Strikes," by Michele Wojciechowski.
KW - LETTERS to the editor
KW - EMERGENCY management
N1 - Accession Number: 25682445; Siegel, Karen Lohmann 1; Affiliation: 1: Chief Therapist Officer, US Public Health Service, Bethesda, MD; Source Info: Jul2007, Vol. 15 Issue 7, p8; Subject Term: LETTERS to the editor; Subject Term: EMERGENCY management; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 1p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alexander, George A.
AU - Swartz, Harold M.
AU - Amundson, Sally A.
AU - Blakely, William F.
AU - Buddemeier, Brooke
AU - Gallez, Bernard
AU - Dainiak, Nicholas
AU - Goans, Ronald E.
AU - Hayes, Robert B.
AU - Lowry, Patrick C.
AU - Noska, Michael A.
AU - Okunieff, Paul
AU - Salner, Andrew L.
AU - Schauer, David A.
AU - Trompier, Francois
AU - Turteltaub, Kenneth W.
AU - Voisin, Phillipe
AU - Wiley, Albert L.
AU - Wilkins, Ruth
T1 - BiodosEPR-2006 Meeting: Acute dosimetry consensus committee recommendations on biodosimetry applications in events involving uses of radiation by terrorists and radiation accidents
JO - Radiation Measurements
JF - Radiation Measurements
Y1 - 2007/07//
VL - 42
IS - 6/7
M3 - Article
SP - 972
EP - 996
SN - 13504487
AB - Abstract: In the aftermath of a radiological terrorism incident or mass-casualty radiation accident, first responders and receivers require prior guidance and pre-positioned resources for assessment, triage and medical management of affected individuals [NCRP, 2005. Key elements of preparing emergency responders for nuclear and radiological terrorism. NCRP Commentary No. 19, Bethesda, Maryland, USA]. Several recent articles [Dainiak, N., Waselenko, J.K., Armitage, J.O., MacVittie, T.J., Farese, A.M., 2003. The hematologist and radiation casualties. Hematology (Am. Soc. Hematol. Educ. Program) 473–496; Waselenko, J.K., MacVittie, T.J., Blakely, W.F., Pesik, N., Wiley, A.L., Dickerson, W.E., Tsu, H., Confer, D.L., Coleman, C.N., Seed, T., Lowry, P., Armitage, J.O., Dainiak, N., Strategic National Stockpile Radiation Working Group, 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann. Intern. Med. 140(12), 1037–1051; Blakely, W.F., Salter, C.A., Prasanna, P.G., 2005. Early-response biological dosimetry—recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 89(5), 494–504; Goans, R.E., Waselenko, J.K., 2005. Medical management of radiation casualties. Health Phys. 89(5), 505–512; Swartz, H.M., Iwasaki, A., Walczak, T., Demidenko, E., Salikhov, I., Lesniewski, P., Starewicz, P., Schauer, D., Romanyukha, A., 2005. Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ. Appl. Radiat. Isot. 62, 293–299; . Acute radiation injury: contingency planning for triage, supportive care, and transplantation. Biol. Blood Marrow Transplant. 12(6), 672–682], national [. Management of persons accidentally contaminated with radionuclides. NCRP Report No. 65, Bethesda, Maryland, USA; . Management of terrorist events involving radioactive material. NCRP Report No. 138, Bethesda, Maryland, USA; NCRP, 2005. Key elements of preparing emergency responders for nuclear and radiological terrorism. NCRP Commentary No. 19, Bethesda, Maryland, USA] and international [IAEA, 2005. Generic procedures for medical response during a nuclear or radiological emergency. EPR-Medical 2005, IAEA, Vienna, Austria] agencies have reviewed strategies for acute-phase biodosimetry. Consensus biodosimetric guidelines include: (a) clinical signs and symptoms, including peripheral blood counts, time to onset of nausea and vomiting and presence of impaired cognition and neurological deficits, (b) radioactivity assessment, (c) personal and area dosimetry, (d) cytogenetics, (e) in vivo electron paramagnetic resonance (EPR) and (f) other dosimetry approaches (i.e. blood protein assays, etc.). Emerging biodosimetric technologies may further refine triage and dose assessment strategies. However, guidance is needed regarding which biodosimetry techniques are most useful for different radiological scenarios and consensus protocols must be developed. The Local Organizing Committee for the Second International Conference on Biodosimetry and Seventh International Symposium on EPR Dosimetry and Applications (BiodosEPR-2006 Meeting) convened an Acute Dosimetry Consensus Committee composed of national and international experts to: (a) review the current literature for biodosimetry applications for acute-phase applications in radiological emergencies, (b) describe the strengths and weaknesses of each technique, (c) provide recommendations for the use of biodosimetry assays for selected defined radiation scenarios, and (d) develop protocols to apply these recommended biological dosimetry techniques with currently available supplies and equipment for first responders. The Acute Dosimetry Consensus Committee developed recommendations for use of a prioritized multiple-assay biodosimetric-based strategy, concluding that no single assay is sufficiently robust to address all of the potential radiation scenarios including management of mass casualties and diagnosis for early medical treatment. These recommendations may be used by first responders/first receivers that span time-windows of (i.e. 0–5 days) after the radiological incident for three radiological scenarios including: (a) radiation exposure device (RED), (b) radiological dispersal device (RDD), and (c) an improvised (or otherwise acquired) nuclear device (IND). Consensus protocols for various bioassays (i.e. signs and symptoms recording, bioassay sampling for radioactivity analysis, nail-clipping sampling for EPR analysis and blood collection for hematology, cytogenetics, and blood chemistry analyses) are presented as Appendix materials. As stated in NCRP Commentary No. 19 [NCRP, 2005. Key elements of preparing emergency responders for nuclear and radiological terrorism. NCRP Commentary No. 19, Bethesda, Maryland, USA], multi-parameter triage (i.e. time to vomiting, lymphocyte kinetics, and other biodosimetry indicators) offers the current best strategy for early assessment of absorbed dose. [Copyright &y& Elsevier]
AB - Copyright of Radiation Measurements is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION
KW - DOSAGE of drugs
KW - PARTICLES (Nuclear physics)
KW - UNITED States
KW - Acute dosimetry
KW - Cytogenetic biodosimetry
KW - Dose assessment
KW - Electron paramagnetic resonance
KW - Medical management of radiation casualties
KW - Radiological triage
N1 - Accession Number: 26681909; Alexander, George A. 1 Swartz, Harold M. 2 Amundson, Sally A. 3 Blakely, William F. 4; Email Address: blakely@afrri.usuhs.mil Buddemeier, Brooke 5 Gallez, Bernard 6 Dainiak, Nicholas 7 Goans, Ronald E. 8 Hayes, Robert B. 9 Lowry, Patrick C. 10 Noska, Michael A. 11 Okunieff, Paul 12 Salner, Andrew L. 13 Schauer, David A. 14 Trompier, Francois 15 Turteltaub, Kenneth W. 16 Voisin, Phillipe 17 Wiley, Albert L. 18 Wilkins, Ruth 19; Affiliation: 1: U.S. Department of Health and Human Services, Office of Preparedness and Emergency Operations, 200 Independence Avenue, SW, Room 403B-1, Washington, DC 20201, USA 2: Department of Radiology and Physiology Department, Dartmouth Medical School, HB 7785, Vail 702, Rubin 601, Hanover, NH 03755, USA 3: Center for Radiological Research, Columbia University Medical Center, 630 W. 168th Street, VC11-215, New York, NY 10032, USA, 4: Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA 5: Science and Technology, U.S. Department of Homeland Security, Washington, DC 20528, USA 6: Biomedical Magnetic Resonance Unit and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, Brussels, Belgium 7: Department of Medicine, Bridgeport Hospital, 267 Grant Street, Bridgeport, CT 06610, USA 8: MJW Corporation, 1422 Eagle Bend Drive, Clinton, TN 37716-4029, USA 9: Remote Sensing Laboratory, MS RSL-47, P.O. Box 98421, Las Vegas, NV 89193, USA 10: Radiation Emergency Assistance Center/Training Site (REAC/TS), Oak Ridge Associated Universities, P.O. Box 117, Oak Ridge, TN 37831-0117, USA 11: Food and Drug Administration, FDA/CDRH, 1350 Piccard Drive, HFZ-240, Rockville, MD 20850, USA 12: Department of Radiation Oncology (Box 647), University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA 13: Helen and Harry Gray Cancer Center, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA 14: National Council on Radiation Protection and Measurements, 7910 Woodmont Avenue, Suite 400, Bethesda, MD 20814-3095, USA 15: Institut de Radioprotection et de Surete Nucleaire (IRSN), BP 17, F-92262-Fontenay-aux-Roses Cedex, France 16: L-452, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA 17: Radiobiology and Epidemiology Department, Institut de Radioprotection et Surete Nucleaire (IRSN), BP 17, F-92262-Fontenay-aux-Roses Cedex, France 18: REAC/TS, Oak Ridge Associated Universities, P.O. Box 117, Oak Ridge, TN 37831-0117, USA 19: Consumer and Clinical Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Postal Locator 6303B, Ottawa Ont., Canada K1A 1C1; Source Info: Jul2007, Vol. 42 Issue 6/7, p972; Subject Term: RADIATION; Subject Term: DOSAGE of drugs; Subject Term: PARTICLES (Nuclear physics); Subject Term: UNITED States; Author-Supplied Keyword: Acute dosimetry; Author-Supplied Keyword: Cytogenetic biodosimetry; Author-Supplied Keyword: Dose assessment; Author-Supplied Keyword: Electron paramagnetic resonance; Author-Supplied Keyword: Medical management of radiation casualties; Author-Supplied Keyword: Radiological triage; Number of Pages: 25p; Document Type: Article
L3 - 10.1016/j.radmeas.2007.05.035
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Colman, Eric
T1 - Dinitrophenol and obesity: An early twentieth-century regulatory dilemma
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/07//
VL - 48
IS - 2
M3 - Editorial
SP - 115
EP - 117
SN - 02732300
AB - Abstract: In the early 1930s, the industrial chemical dinitrophenol found widespread favor as a weight-loss drug, due principally to the work of Maurice Tainter, a clinical pharmacologist from Stanford University. Unfortunately the compound’s therapeutic index was razor thin and it was not until thousands of people suffered irreversible harm that mainstream physicians realized that dinitrophenol’s risks outweighed its benefits and abandoned its use. Yet, it took passage of the Food, Drug, and Cosmetic Act in 1938 before federal regulators had the ability to stop patent medicine men from selling dinitrophenol to Americans lured by the promise of a drug that would safely melt one’s fat away. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Phenols
KW - Nutrition disorders
KW - Metabolic disorders
KW - Body weight
KW - Dinitrophenol
KW - Food and Drug Administration
KW - Obesity
N1 - Accession Number: 25255613; Colman, Eric 1; Email Address: eric.colman@fda.hhs.gov; Affiliations: 1: Division of Metabolism and Endocrinology Products, Office of Drug Evaluation II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Room 3360, Silver Spring, MD 20993, USA; Issue Info: Jul2007, Vol. 48 Issue 2, p115; Thesaurus Term: Phenols; Subject Term: Nutrition disorders; Subject Term: Metabolic disorders; Subject Term: Body weight; Author-Supplied Keyword: Dinitrophenol; Author-Supplied Keyword: Food and Drug Administration; Author-Supplied Keyword: Obesity; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.yrtph.2007.03.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25255613&site=ehost-live&scope=site
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ER -
TY - JOUR
AU - Kauffman, John F.
AU - Westenberger, Benjamin J.
AU - Robertson, J. David
AU - Guthrie, James
AU - Jacobs, Abigail
AU - Cummins, Susan K.
T1 - Lead in pharmaceutical products and dietary supplements
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/07//
VL - 48
IS - 2
M3 - Article
SP - 128
EP - 134
SN - 02732300
AB - Abstract: The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products. Lead concentrations of 45 products were measured with inductively-coupled plasma mass spectrometry. Six products had lead concentrations greater than 100 parts per billion (ppb), and the highest measured concentration was 500ppb. The average mass of lead delivered to consumers by all products examined in this study when taken as directed was 0.22 micrograms per day, which is expected to increase the blood lead level of an adult by less than 1%. Five products were found to deliver more than 1μg of lead per day when used as directed. Current tolerable lead limits in pharmaceutical substances vary widely, and in some cases exceed 10,000ppb. The products examined in this study have lead concentrations far below these levels. However, in light of recent research demonstrating adverse effects in both children and adults from low level lead exposure, current lead limits for pharmaceutical substances are unacceptably high. Uniform lead limits that reflect current manufacturing capabilities are needed to insure the lowest achievable exposure to lead from these products. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Food additives
KW - Drugs
KW - Pharmaceutical industry
KW - Calcium supplements
KW - cGMP
KW - ICP-MS
KW - Lead exposure
KW - Lead toxicity
KW - Pharmaceutical products
KW - USP lead limits
KW - Vitamins
N1 - Accession Number: 25255615; Kauffman, John F. 1; Email Address: John.Kauffman@fda.hhs.gov; Westenberger, Benjamin J. 1; Robertson, J. David 2,3; Guthrie, James 2; Jacobs, Abigail 4; Cummins, Susan K. 5; Affiliations: 1: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, USA; 2: Research Reactor Center, University of Missouri, Columbia, MO, USA; 3: Department of Chemistry, University of Missouri, Columbia, MO, USA; 4: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD, USA; 5: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of the Center Director, Rockville, MD, USA; Issue Info: Jul2007, Vol. 48 Issue 2, p128; Thesaurus Term: Dietary supplements; Thesaurus Term: Food additives; Thesaurus Term: Drugs; Subject Term: Pharmaceutical industry; Author-Supplied Keyword: Calcium supplements; Author-Supplied Keyword: cGMP; Author-Supplied Keyword: ICP-MS; Author-Supplied Keyword: Lead exposure; Author-Supplied Keyword: Lead toxicity; Author-Supplied Keyword: Pharmaceutical products; Author-Supplied Keyword: USP lead limits; Author-Supplied Keyword: Vitamins; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.yrtph.2007.03.001
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Li, S.
AU - Fedorowicz, A.
AU - Andrew, M. E.
T1 - A new descriptor selection scheme for SVM in unbalanced class problem: a case study using skin sensitisation dataset.
JO - SAR & QSAR in Environmental Research
JF - SAR & QSAR in Environmental Research
Y1 - 2007/07//Jul-Sep2007
VL - 18
IS - 5/6
M3 - Article
SP - 423
EP - 441
SN - 1062936X
AB - A novel descriptor selection scheme for Support Vector Machine (SVM) classification method has been proposed and its utility demonstrated using a skin sensitisation dataset as an example. A backward elimination procedure, guided by mean accuracy (the average of specificity and sensitivity) of a leave-one-out cross validation, is devised for the SVM. Subsets of descriptors were first selected using a sequential t-test filter or a Random Forest filter, before backward elimination was applied. Different kernels for SVM were compared using this descriptor selection scheme. The Radial Basis Function (RBF) kernel worked best when a sequential t-test filter was adopted. The highest mean accuracy, 84.9%, was obtained using SVM with 23 descriptors. The sensitivity and the specificity were as high as 93.1% and 76.6%, respectively. A linear kernel was found to be optimal when a Random Forest filter was used. The performance using 24 descriptors was comparable with a RBF kernel with a sequential t-test filter. As a comparison, Fisher's linear discriminant analysis (LDA) under the same descriptor selection scheme was carried out. SVM was shown to outperform the LDA. [ABSTRACT FROM AUTHOR]
AB - Copyright of SAR & QSAR in Environmental Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENVIRONMENTAL research
KW - DISCRIMINANT analysis
KW - MULTIVARIATE analysis
KW - SKIN
KW - RESEARCH
KW - QSAR (Biochemistry)
KW - CASE studies
KW - Fisher's linear discriminant analysis
KW - Skin sensitisation
KW - Support vector machine
KW - Unbalanced data
KW - Variable selection
N1 - Accession Number: 25915764; Li, S. 1 Fedorowicz, A. 2 Andrew, M. E. 2; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA,Department of Statistics, West Virginia University, Morgantown, WV 26506, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Jul-Sep2007, Vol. 18 Issue 5/6, p423; Subject Term: ENVIRONMENTAL research; Subject Term: DISCRIMINANT analysis; Subject Term: MULTIVARIATE analysis; Subject Term: SKIN; Subject Term: RESEARCH; Subject Term: QSAR (Biochemistry); Subject Term: CASE studies; Author-Supplied Keyword: Fisher's linear discriminant analysis; Author-Supplied Keyword: Skin sensitisation; Author-Supplied Keyword: Support vector machine; Author-Supplied Keyword: Unbalanced data; Author-Supplied Keyword: Variable selection; Number of Pages: 19p; Illustrations: 1 Diagram, 12 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/10629360701428474
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, Kuei-Meng
AU - Farrelly, James G.
T1 - Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology
JO - Toxicology
JF - Toxicology
Y1 - 2007/07//
VL - 236
IS - 1/2
M3 - Article
SP - 1
EP - 6
SN - 0300483X
AB - Abstract: Many therapeutic agents are prepared in prodrug forms, which are classified into Type I, II and subtypes A, B based on their sites of conversion. Recently, an increasing number of INDs have appeared as Type II prodrugs that often contain dual tracks of toxicity profile exploration, one on the prodrug and another on the active drug. A comparative toxicology analysis is introduced here to assist reviewers to evaluate the dual toxicity profiles effectively. The analysis helps determine which toxicity is contributed by the prodrug itself, its intermediates, or the active drug itself. As prodrug INDs, or any other new molecular entity (NME) INDs progress into advanced phases of toxicology development, analysis of time-dependent component of toxicity expression, regarding the emergence of new target organs over time, becomes more significant. A strategy is developed to address Pharm/Tox issues such as what duration is required for a toxicity to emerge at the exposure level achieved or dose studied, how many animals in the group are affected, whether the toxicity is a cross-species phenomenon, and whether it is reversible, etc. In conclusion, dual-track comparative toxicology can be useful in the understanding of Type II prodrug''s mechanism of toxicity, and that time-dependent toxicology analysis offers means to detecting new toxicity emergence over time. Both approaches could significantly facilitate secondary and tertiary review processes during IND development of a prodrug or NME. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - PHARMACOLOGY
KW - POISONING
KW - PRODRUGS
N1 - Accession Number: 25187618; Wu, Kuei-Meng; Email Address: kueimeng.wu@fda.hhs.gov Farrelly, James G. 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States; Source Info: Jul2007, Vol. 236 Issue 1/2, p1; Subject Term: TOXICOLOGY; Subject Term: PHARMACOLOGY; Subject Term: POISONING; Subject Term: PRODRUGS; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.tox.2007.04.005
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Leonard, Stephen S.
AU - Castranova, Vince
AU - Chen, Bean T.
AU - Schwegler-Berry, Diane
AU - Hoover, Mark
AU - Piacitelli, Chris
AU - Gaughan, Denise M.
T1 - Particle size-dependent radical generation from wildland fire smoke
JO - Toxicology
JF - Toxicology
Y1 - 2007/07//
VL - 236
IS - 1/2
M3 - Article
SP - 103
EP - 113
SN - 0300483X
AB - Abstract: Firefighting, along with construction, mining and agriculture, ranks among the most dangerous occupations. In addition, the work environment of firefighters is unlike that of any other occupation, not only because of the obvious physical hazards but also due to the respiratory and systemic health hazards of smoke inhalation resulting from combustion. A significant amount of research has been devoted to studying municipal firefighters; however, these studies may not be useful in wildland firefighter exposures, because the two work environments are so different. Not only are wildland firefighters exposed to different combustion products, but their exposure profiles are different. The combustion products wildland firefighters are exposed to can vary greatly in characteristics due to the type and amount of material being burned, soil conditions, temperature and exposure time. Smoke inhalation is one of the greatest concerns for firefighter health and it has been shown that the smoke consists of a large number of particles. These smoke particles contain intermediates of hydrogen, carbon and oxygen free radicals, which may pose a potential health risk. Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. Samples were collected in discrete aerodynamic particle sizes from a wildfire in Alaska, preserved and then shipped to our laboratory for analysis. Electron spin resonance was used to measure carbon-centered as well as hydroxyl radicals produced by a Fenton-like reaction with wildfire smoke. Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. Results demonstrate that coarse size-range particles contained more carbon radicals per unit mass than the ultrafine particles; however, the ultrafine particles generated more ls in the acellular Fenton-like reaction. The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. All particle sizes showed the ability to cause DNA damage. These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FREE radical reactions
KW - FREE radicals (Chemistry)
KW - PARTICLES (Nuclear physics)
KW - ELECTRON paramagnetic resonance
KW - Electron spin resonance
KW - Firefighters
KW - Free radicals
KW - Particulate sampling
KW - Smoke inhalation
N1 - Accession Number: 25187628; Leonard, Stephen S. 1; Email Address: SEL5@cdc.gov Castranova, Vince 1 Chen, Bean T. 1 Schwegler-Berry, Diane 1 Hoover, Mark 2 Piacitelli, Chris 3 Gaughan, Denise M. 3; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA 2: Laboratory Research Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA 3: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Jul2007, Vol. 236 Issue 1/2, p103; Subject Term: FREE radical reactions; Subject Term: FREE radicals (Chemistry); Subject Term: PARTICLES (Nuclear physics); Subject Term: ELECTRON paramagnetic resonance; Author-Supplied Keyword: Electron spin resonance; Author-Supplied Keyword: Firefighters; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Particulate sampling; Author-Supplied Keyword: Smoke inhalation; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.tox.2007.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valerio, Luis G.
AU - Arvidson, Kirk B.
AU - Chanderbhan, Ronald F.
AU - Contrera, Joseph F.
T1 - Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/07//
VL - 222
IS - 1
M3 - Article
SP - 1
EP - 16
SN - 0041008X
AB - Abstract: Consistent with the U.S. Food and Drug Administration (FDA) Critical Path Initiative, predictive toxicology software programs employing quantitative structure–activity relationship (QSAR) models are currently under evaluation for regulatory risk assessment and scientific decision support for highly sensitive endpoints such as carcinogenicity, mutagenicity and reproductive toxicity. At the FDA''s Center for Food Safety and Applied Nutrition''s Office of Food Additive Safety and the Center for Drug Evaluation and Research''s Informatics and Computational Safety Analysis Staff (ICSAS), the use of computational SAR tools for both qualitative and quantitative risk assessment applications are being developed and evaluated. One tool of current interest is MDL-QSAR predictive discriminant analysis modeling of rodent carcinogenicity, which has been previously evaluated for pharmaceutical applications by the FDA ICSAS. The study described in this paper aims to evaluate the utility of this software to estimate the carcinogenic potential of small, organic, naturally occurring chemicals found in the human diet. In addition, a group of 19 known synthetic dietary constituents that were positive in rodent carcinogenicity studies served as a control group. In the test group of naturally occurring chemicals, 101 were found to be suitable for predictive modeling using this software''s discriminant analysis modeling approach. Predictions performed on these compounds were compared to published experimental evidence of each compound''s carcinogenic potential. Experimental evidence included relevant toxicological studies such as rodent cancer bioassays, rodent anti-carcinogenicity studies, genotoxic studies, and the presence of chemical structural alerts. Statistical indices of predictive performance were calculated to assess the utility of the predictive modeling method. Results revealed good predictive performance using this software''s rodent carcinogenicity module of over 1200 chemicals, comprised primarily of pharmaceutical, industrial and some natural products developed under an FDA-MDL cooperative research and development agreement (CRADA). The predictive performance for this group of dietary natural products and the control group was 97% sensitivity and 80% concordance. Specificity was marginal at 53%. This study finds that the in silico QSAR analysis employing this software''s rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity. It is the first study to demonstrate successful QSAR predictive modeling of naturally occurring carcinogens found in the human diet using an external validation test. Further test validation of this software and expansion of the training data set for dietary chemicals will help to support the future use of such QSAR methods for screening and prioritizing the risk of dietary chemicals when actual animal data are inadequate, equivocal, or absent. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - MEDICINE
KW - PHARMACOLOGY
KW - POISONING
KW - Cancer
KW - Carcinogenesis
KW - Computational toxicology
KW - Dietary chemical
KW - Food safety
KW - Natural product
KW - Phytochemical
KW - Predictive toxicology
KW - QSAR
KW - Quantitative structure–activity relationship modeling
KW - Risk assessment
KW - Rodent carcinogenicity
KW - Safety assessment
KW - SAR
N1 - Accession Number: 25488456; Valerio, Luis G. 1; Email Address: luis.valerio@FDA.HHS.gov Arvidson, Kirk B. 2 Chanderbhan, Ronald F. 1 Contrera, Joseph F. 3; Affiliation: 1: Division of Biotechnology and GRAS Notice Review, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA 2: Division of Food Contact Notifications, US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 7Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA 3: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Silver Spring, MD 20993, USA; Source Info: Jul2007, Vol. 222 Issue 1, p1; Subject Term: TOXICOLOGY; Subject Term: MEDICINE; Subject Term: PHARMACOLOGY; Subject Term: POISONING; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Dietary chemical; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: Natural product; Author-Supplied Keyword: Phytochemical; Author-Supplied Keyword: Predictive toxicology; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Quantitative structure–activity relationship modeling; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Rodent carcinogenicity; Author-Supplied Keyword: Safety assessment; Author-Supplied Keyword: SAR; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.taap.2007.03.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calabrese, Edward J.
AU - Bachmann, Kenneth A.
AU - Bailer, A. John
AU - Bolger, P. Michael
AU - Borak, Jonathan
AU - Cai, Lu
AU - Cedergreen, Nina
AU - Cherian, M. George
AU - Chiueh, Chuang C.
AU - Clarkson, Thomas W.
AU - Cook, Ralph R.
AU - Diamond, David M.
AU - Doolittle, David J.
AU - Dorato, Michael A.
AU - Duke, Stephen O.
AU - Feinendegen, Ludwig
AU - Gardner, Donald E.
AU - Hart, Ronald W.
AU - Hastings, Kenneth L.
AU - Hayes, A. Wallace
T1 - Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/07//
VL - 222
IS - 1
M3 - Article
SP - 122
EP - 128
SN - 0041008X
AB - Abstract: Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POISONS -- Physiological effect
KW - HORMESIS
KW - EFFECT of poisons on plants
KW - Adaptive response
KW - Biphasic
KW - Conditioning
KW - Dose–response
KW - Hormesis
KW - Postconditioning
KW - Preconditioning
KW - Stress response
KW - U-shaped
N1 - Accession Number: 25488468; Calabrese, Edward J. 1; Email Address: edwardc@schoolph.umass.edu Bachmann, Kenneth A. 2 Bailer, A. John 3 Bolger, P. Michael 4 Borak, Jonathan 5 Cai, Lu 6 Cedergreen, Nina 7 Cherian, M. George 8 Chiueh, Chuang C. 9 Clarkson, Thomas W. 10 Cook, Ralph R. 11 Diamond, David M. 12 Doolittle, David J. 13 Dorato, Michael A. 14 Duke, Stephen O. 15 Feinendegen, Ludwig 16 Gardner, Donald E. 17 Hart, Ronald W. 18 Hastings, Kenneth L. 4 Hayes, A. Wallace 19; Affiliation: 1: School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA 2: University of Toledo, OH 43606, USA 3: Miami University, FL 33124, USA 4: US Food and Drug Administration, MD 20857, USA 5: Yale University, CT 06520, USA 6: University of Louisville School of Medicine, KY 40292, USA 7: The Royal Veterinary and Agricultural University (KVL), Denmark 8: University of Western Ontario, Canada 9: Taipei Medical University, Taipei, Taiwan 10: University of Rochester, NY 14627, USA 11: RRC Consulting, LLC, TX 78727, USA 12: University of South Florida, FL 33620, USA 13: RJR Tobacco Company, NC 27101, USA 14: Eli Lilly and Company, IN 46285, USA 15: ARS, USDA, MD 20857, USA 16: Heinrich-Heine-University Duesseldorf, Germany 17: Inhalation Toxicology Associates, DC 20006, USA 18: NCTR, US Food and Drug Administration (Retired), MD 20857, USA 19: Harvard University, MA 02114, USA; Source Info: Jul2007, Vol. 222 Issue 1, p122; Subject Term: POISONS -- Physiological effect; Subject Term: HORMESIS; Subject Term: EFFECT of poisons on plants; Author-Supplied Keyword: Adaptive response; Author-Supplied Keyword: Biphasic; Author-Supplied Keyword: Conditioning; Author-Supplied Keyword: Dose–response; Author-Supplied Keyword: Hormesis; Author-Supplied Keyword: Postconditioning; Author-Supplied Keyword: Preconditioning; Author-Supplied Keyword: Stress response; Author-Supplied Keyword: U-shaped; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.taap.2007.02.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25488468&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Levy, Marlon F.
AU - Argaw, Takele
AU - Wilson, Carolyn A.
AU - Brooks, James
AU - Sandstrom, Paul
AU - Merks, Harriet
AU - Logan, John
AU - Klintmalm, Goran
T1 - No evidence of PERV infection in healthcare workers exposed to transgenic porcine liver extracorporeal support.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2007/07//
VL - 14
IS - 4
M3 - Article
SP - 309
EP - 315
PB - Wiley-Blackwell
SN - 0908665X
AB - Background: Clinical xenotransplantation holds great promise by providing one solution to the shortage of human organs for transplantation, while also posing a potential public health threat by facilitating transmission of infectious disease from source animals to humans. One potential vector for infectious disease transmission is healthcare workers (HCW) who are involved in administering xenotransplantation procedures. Methods: In this study, we studied 49 healthcare workers involved in the care of two subjects who participated in a study of porcine liver perfusion as treatment of fulminant hepatic failure. We looked for serologic and virologic evidence of transmission of porcine endogenous retrovirus, and found that HCW had no evidence of infection. Conclusions: Results of our survey demonstrate that application of standard precautions may be sufficient to prevent transmission of porcine endogenous retrovirus, an agent of concern in ex vivo xenotransplantation products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenotransplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - PUBLIC health
KW - COMMUNICABLE diseases -- Transmission
KW - MEDICAL personnel
KW - PERFUSION (Physiology)
KW - LIVER failure
KW - disease transmission
KW - healthcare workers
KW - porcine endogenous retrovirus
N1 - Accession Number: 25946190; Levy, Marlon F. 1; Email Address: marlonl@baylorhealth.edu Argaw, Takele 2 Wilson, Carolyn A. 2 Brooks, James 3 Sandstrom, Paul 3 Merks, Harriet 2 Logan, John 4 Klintmalm, Goran 5; Affiliation: 1: Baylor All Saints Medical Center, Fort Worth, TX, USA 2: Division of Cellular and Gene Therapies, CBER, Food and Drug Administration, Bethesda, MD, USA 3: National HIV and Retrovirology Laboratories, Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, ON, Canada 4: Baxter Healthcare, McGaw Park, IL, USA 5: Baylor University Medical Center-Dallas, Dallas, TX, USA; Source Info: Jul2007, Vol. 14 Issue 4, p309; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: PUBLIC health; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: MEDICAL personnel; Subject Term: PERFUSION (Physiology); Subject Term: LIVER failure; Author-Supplied Keyword: disease transmission; Author-Supplied Keyword: healthcare workers; Author-Supplied Keyword: porcine endogenous retrovirus; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 1 Graph; Document Type: Article
L3 - 10.1111/j.1399-3089.2007.00408.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25946190&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bloom, Eda T.
T1 - National policies for xenotransplantation in the USA.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2007/07//
VL - 14
IS - 4
M3 - Article
SP - 345
EP - 346
PB - Wiley-Blackwell
SN - 0908665X
AB - An overview of xenotransplantation regulatory policies in the USA was presented at the Satellite Symposium, ‘‘Xenotransplantation – Current Standards for Clinical Trials,’’ held in conjunction with the World Transplant Congress, Boston, MA, USA 2006. This article summarizes that overview. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenotransplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - XENOGRAFTS -- Government policy
KW - MEDICAL policy
KW - CLINICAL trials
KW - CONFERENCES & conventions
KW - BOSTON (Mass.)
KW - MASSACHUSETTS
N1 - Accession Number: 25946200; Bloom, Eda T. 1; Email Address: eda.bloom@fda.hhs.gov; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Source Info: Jul2007, Vol. 14 Issue 4, p345; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: XENOGRAFTS -- Government policy; Subject Term: MEDICAL policy; Subject Term: CLINICAL trials; Subject Term: CONFERENCES & conventions; Subject Term: BOSTON (Mass.); Subject Term: MASSACHUSETTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/j.1399-3089.2007.00396.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25946200&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-07744-012
AN - 2007-07744-012
AU - Wu, Li-Tzy
AU - Pilowsky, Daniel J.
AU - Schlenger, William E.
AU - Galvin, Deborah M.
T1 - Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2007/07//
VL - 89
IS - 2-3
SP - 195
EP - 205
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Wu, Li-Tzy, Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, 2213 Elba Street, Civitan Building, Room 240 Duke University Medical Center, Durham, NC, US, 27710
N1 - Accession Number: 2007-07744-012. PMID: 17257780 Partial author list: First Author & Affiliation: Wu, Li-Tzy; Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, US. Release Date: 20070716. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wu, Li-Tzy. Major Descriptor: Drug Abuse; Human Sex Differences; Methamphetamine; Methylphenidate; Prescription Drugs. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul, 2007.
AB - Gender differences in the prevalence and characteristics of misuse of methamphetamine (meth) and prescription stimulants were examined in a representative US sample of youths and young adults aged 16-25 (N= 24,409). Stimulant misusers were categorized into three mutually exclusive subgroups: meth users only, meth and prescription stimulant users, and prescription stimulant users only (e.g., Benzedrine®, Ritalin®, or Dexedrine®). Multinominal logistic regression analyses identified the characteristics associated with misuse of meth and prescription stimulants. About 1 in 10 youths reported any misuse of stimulants in their lifetime. Prescription stimulant misuse occurred earlier and was more frequent than meth misuse. About 47% of meth misusers also reported prescription stimulant misuse. Among misusers of meth and prescription stimulants, males were more likely than females to misuse methylphenidate (82% versus 65%) but were less likely to misuse diet pills or amphetamines (37% versus 49%). Multinominal logistic regression analyses indicated that all subgroups of lifetime stimulant misuse were associated with past year substance abuse. The characteristics of meth misusers differed slightly from prescription stimulants misusers. Multidrug use is common among stimulant misusers. Parents should be informed about the risk of prescription stimulant misuse by their youths. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender differences
KW - misuse
KW - methamphetamine
KW - prescription stimulants
KW - methylphenidate
KW - amphetamines
KW - 2007
KW - Drug Abuse
KW - Human Sex Differences
KW - Methamphetamine
KW - Methylphenidate
KW - Prescription Drugs
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Prevention, Division of Workplace Programs, US. Grant: 270-2003-00001. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R21DA015938. Recipients: Wu, Li-Tzy
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Office of Applied Studies, US. Other Details: NSDUH. Recipients: No recipient indicated
DO - 10.1016/j.drugalcdep.2006.12.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07744-012&site=ehost-live&scope=site
UR - litzywu@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11894-006
AN - 2007-11894-006
AU - Gunther, Nicole
AU - Drukker, Marjan
AU - Feron, Frans
AU - van Os, Jim
T1 - No ecological effect modification of the association between negative life experiences and later psychopathology in adolescence: A longitudinal community study in adolescents.
JF - European Psychiatry
JO - European Psychiatry
JA - Eur Psychiatry
Y1 - 2007/07//
VL - 22
IS - 5
SP - 296
EP - 304
CY - Netherlands
PB - Elsevier Science
SN - 0924-9338
AD - Gunther, Nicole, Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO Box 616 (Vijvl), 6200 MD, Maastricht, Netherlands
N1 - Accession Number: 2007-11894-006. PMID: 17524627 Other Journal Title: Psychiatrie & Psychobiologie. Partial author list: First Author & Affiliation: Gunther, Nicole; Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, Netherlands. Release Date: 20070813. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ecology; Life Experiences; Psychopathology; Social Capital; Bullying. Minor Descriptor: Adolescent Development; Neighborhoods. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2007.
AB - Background: The aim of the study was to examine the potential contribution of exposure to bullying and adverse life events to the development of psychopathology in adolescents, and possible effect modification by neighbourhood social capital. Methods: Two waves of routine, longitudinal, standard health examinations at local community paediatric health services, pertaining to 749 adolescents living in Maastricht (The Netherlands) who were attending second grade of secondary school (age 13/14 years) and approximately 2 years later going to the fourth grade (age 15/16 years), were analysed. A self-report questionnaire was used, including measures of psychopathology and two measures of negative life experiences, exposure to bullying and adverse life events, that were available for both age groups and subjected to (multilevel) regression analysis. Results: Exposure to bullying in the past school-year as well as the experience of adverse life events over a 12 month period, at the age of 13/14 years, predicted an increase in psychopathology at follow-up. Exposure to bullying was associated with the development of hyperactivity and emotional problems, while the experience of adverse life events predicted the development of conduct problems. Family-related adverse events had greatest effect sizes. Effects of bullying and adverse life events were not moderated by neighbourhood social capital. Conclusion: Negative life experiences impact on liability to psychopathology in adolescents independent of the wider social environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neighborhood social capital
KW - life experiences
KW - psychopathology
KW - adolescence
KW - bullying
KW - adverse life events
KW - ecological effect modification
KW - 2007
KW - Ecology
KW - Life Experiences
KW - Psychopathology
KW - Social Capital
KW - Bullying
KW - Adolescent Development
KW - Neighborhoods
KW - 2007
DO - 10.1016/j.eurpsy.2007.03.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11894-006&site=ehost-live&scope=site
UR - n.gunther@sp.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12182-002
AN - 2007-12182-002
AU - Woo, Emily Jane
AU - Ball, Robert
AU - Landa, Rebecca
AU - Zimmerman, Andrew W.
AU - Braun, M. Miles
T1 - Developmental regression and autism reported to the Vaccine Adverse Event Reporting System.
JF - Autism
JO - Autism
JA - Autism
Y1 - 2007/07//
VL - 11
IS - 4
SP - 301
EP - 310
CY - US
PB - Sage Publications
SN - 1362-3613
SN - 1461-7005
AD - Woo, Emily Jane, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD, US, 20852
N1 - Accession Number: 2007-12182-002. PMID: 17656395 Partial author list: First Author & Affiliation: Woo, Emily Jane; Center for Biologics Evaluation and Research, Food and Drug Administration, MD, US. Institutional Authors: Vaers Working Group, Center for Biologics Evaluation and Research, Food and Drug Administration. Release Date: 20071008. Correction Date: 20161215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Autism Spectrum Disorders; Developmental Disabilities; Immunization. Minor Descriptor: Etiology; Medical Records. Classification: Developmental Disorders & Autism (3250). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Tests & Measures: Social Communication Questionnaire; Autism Diagnostic Interview-Revised DOI: 10.1037/t18128-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2007.
AB - We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - autism
KW - vaccination
KW - US Vaccine Adverse Event Reporting System
KW - developmental disorder
KW - developmental regression
KW - medical records
KW - 2007
KW - Autism Spectrum Disorders
KW - Developmental Disabilities
KW - Immunization
KW - Etiology
KW - Medical Records
KW - 2007
U1 - Sponsor: National Vaccine Program Office. Recipients: No recipient indicated
DO - 10.1177/1362361307078126
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12182-002&site=ehost-live&scope=site
UR - jane.woo@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08096-008
AN - 2008-08096-008
AU - Teich, Judith L.
AU - Buck, Jeffrey A.
T1 - Mental health benefits in employer-sponsored health plans, 1997-2003.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2007/07//
VL - 34
IS - 3
SP - 343
EP - 348
CY - Germany
PB - Springer
SN - 1094-3412
AD - Teich, Judith L., Office of Organization and Financing, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 6-1065, Rockville, MD, US, 20857
N1 - Accession Number: 2008-08096-008. PMID: 17357852 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Teich, Judith L.; Office of Organization and Financing, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20081208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Health Insurance; Mental Health Services; Health Care Policy. Classification: Personnel Management & Selection & Training (3620). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 2007.
AB - Data drawn from the Mercer National Survey of Employer-sponsored Health Plans in 1997 and 2003 indicate that a large majority of employers continue to provide some level of coverage for mental health (MH) services in their primary plans. However, a majority of plans continue to impose different benefit limitations for MH than for other medical treatment. Among plans with limitations on MH coverage, there was a sharp increase in the use of limits on inpatient days and outpatient visits between 1997 and 2003. The proportion of employers providing coverage for some MH services decreased; e.g., among small employers, 88% provided coverage for inpatient MH care in 2003, compared with 94% in 1997. These results suggest that parity legislation has had a noticeable but limited effect, but that, at least in the short-term, it is unlikely that universal parity in employer-based plans will be achieved through a legislative strategy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health benefits
KW - employer sponsored health plans
KW - health care policy
KW - 2007
KW - Employee Health Insurance
KW - Mental Health Services
KW - Health Care Policy
KW - 2007
DO - 10.1007/s11414-006-9050-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08096-008&site=ehost-live&scope=site
UR - jeff.buck@samhsa.hhs.gov
UR - judith.teich@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08802-004
AN - 2007-08802-004
AU - Lowe, Brian D.
AU - Kong, Yong-Ku
AU - Krieg, Edward
AU - Wurzelbacher, Steven
AU - Lee, Soo-Jin
T1 - A field investigation of manual forces associated with trigger and push to start electric screwdrivers.
JF - Human Factors and Ergonomics in Manufacturing
JO - Human Factors and Ergonomics in Manufacturing
JA - Hum Factors Ergon Manuf
Y1 - 2007/07//Jul-Aug, 2007
VL - 17
IS - 4
SP - 367
EP - 382
CY - US
PB - John Wiley & Sons
SN - 1090-8471
SN - 1520-6564
AD - Lowe, Brian D., National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, Mail Stop C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-08802-004. Other Journal Title: Human Factors and Ergonomics in Manufacturing & Service Industries. Partial author list: First Author & Affiliation: Lowe, Brian D.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20070917. Correction Date: 20100118. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Apparatus; Human Factors Engineering; Human Machine Systems Design. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jul-Aug, 2007.
AB - This study investigated manual forces associated with trigger start (TS) and push to start (PTS) activation in-line electric screwdriver designs. The vertically directed axial screwdriver force transmitted with the driver to the fastener and the grip/finger forces on the driver handle were measured from 13 employees in an electronics assembly manufacturing facility. The PTS driver was associated with significantly (p<.01) higher axial force than the TS driver at two of the four workstations, where the difference was as high as a 184% increase (36.5 vs. 103.8 N). Total finger force on the screwdriver handle was also higher for the PTS screwdriver (p<.01). The PTS screwdriver may reduce instances of fastener head damage ('cam out') by requiring a minimum level of axial force to ensure better contact between the screwdriver bit and the fastener. However, this appears to come at the expense of greater manual forces exerted by the operator. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - manual forces
KW - trigger start
KW - push to start
KW - electric screwdriver
KW - electronics assembly
KW - 2007
KW - Apparatus
KW - Human Factors Engineering
KW - Human Machine Systems Design
KW - 2007
DO - 10.1002/hfm.20079
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08802-004&site=ehost-live&scope=site
UR - blowe@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-08565-005
AN - 2007-08565-005
AU - Wright, L. K. M.
AU - Popke, E. J.
AU - Allen, R. R.
AU - Pearson, E. C.
AU - Hammond, T. G.
AU - Paule, M. G.
T1 - Effect of chronic MK-801 and/or phenytoin on the acquisition of complex behaviors in rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2007/07//
VL - 29
IS - 4
SP - 476
EP - 491
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Wright, L. K. M., Center for Veterinary Health Sciences, Oklahoma State University, 165 McElroy Hall, Stillwater, OK, US, 74078-2014
N1 - Accession Number: 2007-08565-005. PMID: 17376648 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Wright, L. K. M.; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, US. Release Date: 20070813. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Channel Blockers; Diphenylhydantoin; N-Methyl-D-Aspartate; Performance; Sodium. Minor Descriptor: Animal Ethology; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jul, 2007.
AB - The purpose of the present experiment was to assess the effects of chronic MK-801 (an N-methyl-D-aspartate receptor antagonist) and/or phenytoin (a sodium channel blocker) treatment on behavioral acquisition and performance in rats. Learning, audio/visual discrimination and motivation were modeled using incremental repeated acquisition (IRA), audio/visual discrimination (AVD) and progressive ratio (PR) tasks, respectively. MK-801 and/or phenytoin were administered daily, 7 days/week by orogastric gavage beginning just after weaning on postnatal day (PND) 23 and continuing until PND 306. Monday through Friday behavioral assessments began on PND 27 and continued until PND 430. Throughout treatment, subjects in the high dose MK-801 (1.0 mg/kg/day) and the high dose drug combination (1.0 mg/kg/day MK-801+150 mg/kg/day phenytoin) groups exhibited decreased body weight gains compared to control subjects. For these two affected groups, response rates were also decreased in all tasks. Task acquisition, as evidenced by an increase in response accuracy, was decreased for both these groups in the AVD task, but only for the high dose MK-801 group in the IRA task. The data suggest that chronic MK-801 treatment adversely affects the acquisition of IRA and AVD task performance and that the inclusion of phenytoin in the MK-801 dosing regimen blocks some of the adverse effects of chronic MK-801 treatment on IRA task acquisition. These findings are in marked contrast with those observed in nonhuman primates and suggest important species differences associated with chronic exposure to compounds that block NMDA receptors and/or sodium channels. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chronic MK-801
KW - phenytoin
KW - complex behaviors acquisition
KW - rats
KW - N-methyl-D-aspartate receptor antagonist
KW - sodium channel blocker
KW - performance
KW - 2007
KW - Channel Blockers
KW - Diphenylhydantoin
KW - N-Methyl-D-Aspartate
KW - Performance
KW - Sodium
KW - Animal Ethology
KW - Rats
KW - 2007
U1 - Sponsor: AstraZeneca. Other Details: Cooperative Research and Development Agreement. Recipients: No recipient indicated
U1 - Sponsor: National Center for Toxicological Research. Recipients: No recipient indicated
DO - 10.1016/j.ntt.2007.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-08565-005&site=ehost-live&scope=site
UR - linnzi.wright@okstate.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09275-003
AN - 2007-09275-003
AU - Fleishman, John A.
AU - Zuvekas, Samuel H.
T1 - Global self-rated mental health: Associations with other mental health measures and with role functioning.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2007/07//
VL - 45
IS - 7
SP - 602
EP - 609
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Fleishman, John A., Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-09275-003. PMID: 17571008 Partial author list: First Author & Affiliation: Fleishman, John A.; Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20071105. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health; Rating; Self-Perception. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Self-Administered Questionnaire; K6 scale; Medical Expenditure Panel Survey; SF-36 Health Survey; Patient Health Questionnaire DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2007.
AB - Background: A large body of research shows that global self-rated health is related to important outcome variables. Increasingly, studies also obtain a single global self-rating of mental health, but understanding of what this item measures is limited. Objective: To clarify interpretation of self-reported mental health, we examine its associations with other validated measures of mental health and role functioning. Research Design: We conducted cross-sectional analyses of nationally representative data from the Medical Expenditure Panel Survey. Measures: In-person household interviews obtained data on global self-reported mental health and any limitations in work, school, or housekeeping activities. Adult respondents (N = 11,109) completed the SF-12 health status survey, the K6 scale of nonspecific psychologic distress, and the Patient Health Questionnaire (PHQ-2) depression screener in a self-administered questionnaire. We used the SF-12 Mental Component Summary and the mental health subscale. Analyses examined associations among mental health measures and regressed activity limitations, and the SF-12 physical and emotional role functioning scales on mental health measures, controlling for demographics and selected chronic conditions. Results: The 4 multi-item mental health measures were strongly correlated with each other (r > 0.69), but correlated less strongly with the self-reported mental health item (r ≈ 0.4). In an exploratory factor analysis, self-reported mental health loaded on both mental and physical health factors. In multivariate analyses, each mental health variable was significantly associated with activity limitations and with role functioning, but the association of self-reported mental health with emotional role functioning was relatively weak. Conclusions: Although global self-rated mental health is related to symptoms of psychologic distress, it cannot be considered to be a substitute for them. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - global self-rated health
KW - factor analysis
KW - 2007
KW - Mental Health
KW - Rating
KW - Self-Perception
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality, US. Recipients: No recipient indicated
DO - 10.1097/MLR.0b013e31803bb4b0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09275-003&site=ehost-live&scope=site
UR - jfleishm@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09275-006
AN - 2007-09275-006
AU - Yabroff, K. Robin
AU - McNeel, Timothy S.
AU - Waldron, William R.
AU - Davis, William W.
AU - Brown, Martin L.
AU - Clauser, Steven
AU - Lawrence, William F.
T1 - Health limitations and quality of life associated with cancer and other chronic diseases by phase of care.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2007/07//
VL - 45
IS - 7
SP - 629
EP - 637
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Yabroff, K. Robin, Health Services and Economics Branch/Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North, Room 4005, 6130 Executive Blvd., MSC 7344, Bethesda, MD, US, 20892-7344
N1 - Accession Number: 2007-09275-006. PMID: 17571011 Partial author list: First Author & Affiliation: Yabroff, K. Robin; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, US. Release Date: 20071105. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Illness; Health; Mental Health Services; Neoplasms; Quality of Life. Minor Descriptor: Health Care Delivery. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Medical Expenditure Panel Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2007.
AB - Objective: To estimate health limitations and health-related quality of life (HRQL) associated with cancer and other chronic conditions in a nationally representative sample within a phase-of-care framework. Study Design and Setting: We used a nested case-control design to assess health limitations and HRQL in individuals reporting a breast, colorectal, prostate, or lung cancer diagnosis, or a diagnosis of arthritis, diabetes, heart disease, or hypertension compared with similar controls without these conditions. All subjects were selected from the 1986-1994 National Health Interview Surveys linked to mortality files in 1995, and classified into the initial, continuing, or last year of life phase of care. Health limitations and HRQL were compared for cases and controls for each condition with 2-sided statistical tests. Results: Across all conditions, individuals in the last year of life phase of care reported greater health limitations and lower HRQL, as measured by the Health Activities and Limitations Index (HALex), than did individuals in the initial and continuing phases of care. Compared with their matched controls, individuals with cancer or other chronic conditions were more likely to report health limitations and lower mean HALex values in the initial, continuing, and last year of life phases of care (P < 0.05). Conclusions: We observed greater health limitations and lower HRQL associated with cancer and other chronic diseases compared with similar individuals without these conditions. The phase-of-care framework used in this study seems to be applicable to the assessment of HRQL for cancer and other chronic diseases. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health limitations
KW - health-related quality of life
KW - cancer
KW - chronic diseases
KW - health care services
KW - 2007
KW - Chronic Illness
KW - Health
KW - Mental Health Services
KW - Neoplasms
KW - Quality of Life
KW - Health Care Delivery
KW - 2007
DO - 10.1097/MLR.0b013e318045576a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09275-006&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-0644-5572
UR - yabroffr@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10971-007
AN - 2007-10971-007
AU - Zandi, P. P.
AU - Badner, J. A.
AU - Steele, J.
AU - Willour, V. L.
AU - Miao, K.
AU - MacKinnon, D. F.
AU - Mondimore, F. M.
AU - Schweizer, B.
AU - Mclnnis, M. G.
AU - DePaulo, J. R. Jr.
AU - Gershon, E.
AU - McMahon, F. J.
AU - Potash, J. B.
T1 - Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2007/07//
VL - 12
IS - 7
SP - 630
EP - 639
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Zandi, P. P., Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 North Broadway, Baltimore, MD, US, 21205
N1 - Accession Number: 2007-10971-007. PMID: 17505464 Partial author list: First Author & Affiliation: Zandi, P. P.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US. Release Date: 20071008. Correction Date: 20140519. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Zandi, P. P. Major Descriptor: Bipolar Disorder; Genes; Genetic Linkage; Genome; Susceptibility (Disorders). Classification: Affective Disorders (3211). Population: Human (10). Location: US. Tests & Measures: Schedule for Affective Disorders and Schizophrenia DOI: 10.1037/t07870-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2007.
AB - Despite compelling evidence that genetic factors contribute to bipolar disorder (BP), attempts to identify susceptibility genes have met with limited success. This may be due to the genetic heterogeneity of the disorder. We sought to identify susceptibility loci for BP in a genome-wide linkage scan with and without clinical covariates that might reflect the underlying heterogeneity of the disorder. We genotyped 428 subjects in 98 BP families at the Center for Inherited Disease Research with 402 microsatellite markers. We first carried out a nonparametric linkage analysis with MERLIN, and then reanalyzed the data with LODPAL to incorporate clinical covariates for age at onset (AAO), psychosis and comorbid anxiety. We sought to further examine the top findings in the covariate analysis in an independent sample of 64 previously collected BP families. In the non-parametric linkage analysis, three loci were nominally significant under a narrow diagnostic model and seven other loci were nominally significant under a broader model. The top findings were on chromosomes 2q24 and 3q28. The covariate analyses yielded additional evidence for linkage on 3q28 with AAO in the primary and independent samples. Although none of the linked loci were genome-wide significant, their congruence with prior results and, for the covariate analyses, their identification in two separate samples increases the likelihood that they are true positives and deserve further investigation. These findings further demonstrate the value of considering clinical features that may reflect the underlying heterogeneity of disease in order to facilitate gene mapping. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bipolar pedigrees
KW - clinical covariates
KW - genetic factors
KW - susceptibility genes
KW - genome-wide linkage
KW - 2007
KW - Bipolar Disorder
KW - Genes
KW - Genetic Linkage
KW - Genome
KW - Susceptibility (Disorders)
KW - 2007
U1 - Sponsor: National Institute of Mental Health. Recipients: No recipient indicated
U1 - Sponsor: Charles A. Dana Foundation. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Stanley Medical Research Institute. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health. Grant: K01-MH072866. Recipients: Zandi, P. P.
U1 - Sponsor: US Public Health Service, National Center for Research Resources, US. Grant: RR03655. Recipients: No recipient indicated
DO - 10.1038/sj.mp.4002027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10971-007&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - pzandi@jhsph.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11722-002
AN - 2007-11722-002
AU - Basu, Jayasree
AU - Friedman, Bernard
T1 - A re-examination of distance as a proxy for severity of illness and the implications for differences in utilization by race/ethnicity.
JF - Health Economics
JO - Health Economics
JA - Health Econ
Y1 - 2007/07//
VL - 16
IS - 7
SP - 687
EP - 701
CY - US
PB - John Wiley & Sons
SN - 1057-9230
SN - 1099-1050
AD - Basu, Jayasree, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-11722-002. PMID: 17191272 Partial author list: First Author & Affiliation: Basu, Jayasree; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20080526. Correction Date: 20130114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Southeastern Health Economics Study Group Conference, Nov, 2003, Charleston, SC, US. Major Descriptor: Commuting (Travel); Geriatric Patients; Hospitalization; Racial and Ethnic Differences; Severity (Disorders). Minor Descriptor: Ethnic Identity; Health Care Utilization; Hospital Admission; Quality of Care; Whites. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Appended. References Available: Y. Page Count: 15. Issue Publication Date: Jul, 2007.
AB - The study analyzes the hospitalization patterns of elderly residents to examine whether the relation between distant travel and severity of illness is uniform across racial/ethnic subgroups. A hypothesis is made that severity thresholds could be higher for minorities than whites. Hospital discharge data from the Healthcare Cost and Utilization Project (HCUP-SID) of the Agency for Health Care Research and Quality for New York residents is used, with a link to the Area Resource File and American Hospital Association's survey files. Logistic models compare the association of distant admission with severity corresponding to each local threshold level, race, and type of hospital admission. The study uses four discrete distance thresholds in contrast to recent work. Also, an examination of severity thresholds for distant travel for different types of admission may clarify different sources of disparities in health care utilization. The findings indicate that minorities are likely to have higher severity thresholds than whites in seeking distant hospital care, although these conclusions depend on the type of condition. The study results imply that if costly elective services were regionalized to get the advantages of high volume for both cost and quality of care, some extra effort at outreach may be desirable to reduce disparities in appropriate care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - severity of illness
KW - race
KW - ethnicity
KW - hospitalization patterns
KW - elderly residents
KW - distant travel
KW - 2007
KW - Commuting (Travel)
KW - Geriatric Patients
KW - Hospitalization
KW - Racial and Ethnic Differences
KW - Severity (Disorders)
KW - Ethnic Identity
KW - Health Care Utilization
KW - Hospital Admission
KW - Quality of Care
KW - Whites
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1002/hec.1192
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11722-002&site=ehost-live&scope=site
UR - Jbasu@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12518-004
AN - 2007-12518-004
AU - Obias-Manno, Dulce
AU - Scott, Pamela E.
AU - Kaczmarczyk, Joseph
AU - Miller, Margaret
AU - Pinnow, Ellen
AU - Lee-Bishop, Lynda
AU - Jones-London, Michelle
AU - Chapman, Kennerly
AU - Kallgren, Deborah
AU - Uhl, Kathleen
T1 - The Food and Drug Administration Office of Women's Health: Impact of science on regulatory policy.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2007/07//
VL - 16
IS - 6
SP - 807
EP - 817
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Scott, Pamela E., Food and Drug Administration, FDA/OC/Office of Women's Health, 5600 Fishers Lane, Room 16-65 HF-8, Rockville, MD, US, 20857
N1 - Accession Number: 2007-12518-004. PMID: 17678451 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Obias-Manno, Dulce; Food and Drug Administration, FDA/OC/Office of Women's Health, Rockville, MD, US. Release Date: 20071008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health; Human Females; Policy Making. Minor Descriptor: Dietary Supplements; Drug Therapy. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). References Available: Y. Page Count: 11. Issue Publication Date: Jul, 2007.
AB - In 1994, the Food and Drug Administration Office of Women's Health (FDA-OWH) was created to provide leadership and policy direction for the Agency regarding issues of women's health. Within its first year, the FDA-OWH established a science program for women's health research, promoting the development of sound policy and regulation. In a little over a decade, the program has provided approximately $14 million to fund more than 100 women's health research studies covering a broad range of health topics affecting women across their lifespan. Some studies, such as those elucidating drug effects on QT prolongation in women and drug-dietary supplement interaction, have had significant influence on regulatory decisions. Other studies have provided sound scientific data on sex and gender differences supporting FDA guidelines to protect women's health. This paper describes the science program at the FDA-OWH, providing examples of how funded research impacts regulatory policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Food and Drug Administration Office of Women's Health
KW - regulatory policy
KW - science program
KW - research
KW - dietary supplements
KW - drug effects
KW - 2007
KW - Experimentation
KW - Health
KW - Human Females
KW - Policy Making
KW - Dietary Supplements
KW - Drug Therapy
KW - 2007
DO - 10.1089/jwh.2006.0135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12518-004&site=ehost-live&scope=site
UR - Pamela.Scott@FDA.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09285-005
AN - 2007-09285-005
AU - Scott, Lionel D. Jr.
AU - Munson, Michelle R.
AU - McMillen, J. Curtis
AU - Snowden, Lonnie R.
T1 - Predisposition to seek mental health care among Black males transitioning from foster care.
JF - Children and Youth Services Review
JO - Children and Youth Services Review
JA - Child Youth Serv Rev
Y1 - 2007/07//
VL - 29
IS - 7
SP - 870
EP - 882
CY - Netherlands
PB - Elsevier Science
SN - 0190-7409
AD - Scott, Lionel D. Jr.
N1 - Accession Number: 2007-09285-005. PMID: 17710190 Partial author list: First Author & Affiliation: Scott, Lionel D. Jr.; School of Social Work, Georgia State University, Atlanta, GA, US. Release Date: 20070820. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blacks; Health Care Utilization; Help Seeking Behavior; Human Males; Sex Role Attitudes. Minor Descriptor: Foster Care; Life Changes; Mental Health Services. Classification: Community & Social Services (3373). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Cultural Mistrust Inventory; Attitudes Toward Seeking Professional Psychological Help Scale; Conformity to Masculinity Norms Inventory DOI: 10.1037/t05550-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jul, 2007.
AB - This study examined the predisposition to seek mental health care in the future for personal and mental health problems among Black males transitioning from the foster care system (n = 74). Results of simultaneous multiple regression analysis showed that custody status, diagnosis of a DSM-IV psychiatric disorder, and emotional control contributed significantly to the prediction of Black male's predisposition to seek mental health care. Specifically, Black males who were still in foster care were more predisposed to seek mental health care, whereas those diagnosed with a DSM-IV psychiatric disorder and who adhered more to the norm of emotional control were less predisposed to seek mental health care. Implications for mental health service delivery are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - black males
KW - mental health services utilization
KW - help-seeking behavior
KW - masculine norms
KW - foster care transition
KW - 2007
KW - Blacks
KW - Health Care Utilization
KW - Help Seeking Behavior
KW - Human Males
KW - Sex Role Attitudes
KW - Foster Care
KW - Life Changes
KW - Mental Health Services
KW - 2007
U1 - Sponsor: National Institute of Mental Health. Grant: 5R03MH067124-02. Recipients: No recipient indicated
DO - 10.1016/j.childyouth.2007.01.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09285-005&site=ehost-live&scope=site
UR - lscottjr@gsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13760-016
AN - 2007-13760-016
AU - Dausey, David J.
AU - Pincus, Harold Alan
AU - Herrell, James M.
AU - Rickards, Lawrence
T1 - States' early experience in improving systems-level care for persons with co-occurring disorders.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/07//
VL - 58
IS - 7
SP - 903
EP - 905
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Dausey, David J., 4570 5th Ave., Suite 600, Pittsburgh, PA, US, 15213
N1 - Accession Number: 2007-13760-016. PMID: 17602004 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Dausey, David J.; RAND Health, Pittsburgh, PA, US. Release Date: 20071119. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Column/Opinion. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Early Experience; Mental Disorders. Minor Descriptor: Mental Health. Classification: Psychological Disorders (3210). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jul, 2007.
AB - This column discusses the experiences of the original cohort of seven states participating in the first two years of a national demonstration project known as the Co-occurring State Incentive Grant (COSIG) initiative. COSIG was designed to help state mental health and substance abuse authorities develop innovative strategies to better integrate or coordinate services for persons with co-occurring mental and substance use disorders. Powerful factors of early project success included careful planning, which was based on experience with anticipating and planning around bureaucratic barriers, and gaining early consensus from a few key stakeholders. The column describes the implementation successes and challenges of these states and the lessons learned from these experiences so that states in the planning phases of similar projects or other infrastructure improvement projects may benefit. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - early experiences
KW - improving systems level care
KW - cooccurring disorders
KW - mental health problems
KW - substance abuse
KW - 2007
KW - Comorbidity
KW - Drug Abuse
KW - Early Experience
KW - Mental Disorders
KW - Mental Health
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 04-M000030; 03-M0002980-1D. Recipients: No recipient indicated
U1 - Sponsor: Robert Wood Johnson Foundation, Substance Abuse Policy Research Program. Recipients: No recipient indicated
DO - 10.1176/appi.ps.58.7.903
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13760-016&site=ehost-live&scope=site
UR - dausey@rand.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13760-014
AN - 2007-13760-014
AU - Teich, Judith L.
AU - Ireys, Henry T.
T1 - A national survey of state licensing, regulating, and monitoring of residential facilities for children with mental illness.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/07//
VL - 58
IS - 7
SP - 991
EP - 998
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Teich, Judith L., Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Room 6-1065, Rockville, MD, US, 20857
N1 - Accession Number: 2007-13760-014. PMID: 17602017 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Teich, Judith L.; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20071119. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Monitoring; Policy Making; Professional Licensing; Residential Care Institutions. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2007.
AB - Objective: Little national information is available to help policy makers understand the methods that states use to regulate residential facilities for children with mental illness. This article describes the results of a government-sponsored survey of state officials that examined how states license, regulate, and monitor such facilities. Methods: Questionnaires were mailed to selected officials in each of the 50 states and the District of Columbia, followed by extensive telephone and e-mail contacts. Questionnaire items covered program characteristics, licensing and accreditation, mandated services, monitoring and oversight methods, and payment sources. Results: Information was gathered on 71 types of residential facilities in 38 states, accounting for 3,628 separate residential facilities with 50,507 beds as of September 30, 2003. States differed widely in the types of residential facilities that they regulate and their mix of regulatory methods, which included requirements for announced and unannounced visits, mandated staff-to-client ratios, minimum levels of education for facility directors, specifications for licensing practices and critical incident reporting, mandated complaint review procedures, and accreditation from designated organizations. Welfare, mental health, and health departments all participated in regulating facilities. Conclusions: States relied on at least several regulatory methods, but no state used all of the possible methods. The regulatory environment is complex in most states because several agencies are involved in licensing, regulating, and reviewing complaints. To ensure that residential facilities effectively address the needs of children with mental illness and their families, policy makers should review and improve their state's data on methods for regulating residential facilities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state licensing
KW - regulating
KW - monitoring
KW - residential facilities
KW - mental illness
KW - policy making
KW - 2007
KW - Mental Disorders
KW - Monitoring
KW - Policy Making
KW - Professional Licensing
KW - Residential Care Institutions
KW - 2007
DO - 10.1176/appi.ps.58.7.991
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13760-014&site=ehost-live&scope=site
UR - judith.teich@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10094-008
AN - 2007-10094-008
AU - Ayalon, Liat
AU - Mackin, Scott
AU - Arean, Patricia A.
AU - Chen, Hongtu
AU - Herr, Elizabeth C. McDonel
T1 - The role of cognitive functioning and distress in suicidal ideation in older adults.
JF - Journal of the American Geriatrics Society
JO - Journal of the American Geriatrics Society
JA - J Am Geriatr Soc
Y1 - 2007/07//
VL - 55
IS - 7
SP - 1090
EP - 1094
CY - United Kingdom
PB - Blackwell Publishing
SN - 0002-8614
SN - 1532-5415
AD - Ayalon, Liat, School of Social Work, Bar Ilan University, Ramat Gan, Israel, 52900
N1 - Accession Number: 2007-10094-008. PMID: 17608884 Partial author list: First Author & Affiliation: Ayalon, Liat; School of Social Work, Bar Ilan University, Ramat Gan, Israel. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20070813. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual meeting of the American Association of Geriatric Psychiatry, 2006. Grant Information: Herr, Elizabeth C. McDonel. Conference Note: Portions of this paper were presented at the aforementioned conference. Major Descriptor: Cognitive Ability; Distress; Geriatric Patients; Primary Health Care; Suicidal Ideation. Minor Descriptor: Clinics; Demographic Characteristics. Classification: Behavior Disorders & Antisocial Behavior (3230); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Short Orientation Memory Concentration Test; General Health Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jul, 2007.
AB - Objectives: To evaluate the role of cognitive functioning and other clinical and demographic characteristics as potential predictors of suicidal ideation in older primary care patients. Design: Cross-sectional. Setting: Primary care clinics at three Department of Veterans Affairs Medical Centers, three community health centers, and two hospital networks. Participants: Fifteen thousand five hundred ninety older adults without dementia who were receiving primary care (mean age ± standard deviation 74.0 ± 6.4; 62.8% men). Measurements: Hierarchical logistic regressions were conducted with passive (e.g., thoughts of being better off dead) and active (e.g., thoughts of hurting one self) suicidal ideation as outcome variables. All demographic variables (age, sex, marital status, and ethnicity) were entered in the first block. All clinical variables (distress, cognitive functioning, alcohol consumption, and perceived health) were entered in the second block. Results: In addition to the typical demographic predictors of late-life suicide (age, martial status, and ethnicity), having poorer cognitive functioning, poorer health, and greater mental distress were associated with passive suicidal ideation (chi-square (χ²) (14, n = 14,618) = 1,192.12, P < .001). Younger age, female sex, poorer cognitive functioning, and greater mental distress were associated with active suicidal ideation (χ²(14, n = 14,605) = 205.35, P < .001). Conclusion: Distress and cognitive impairment are the only two variables that consistently predicted passive and active suicidal ideation. Primary care providers who work with older adults need to take both into consideration when evaluating suicidal ideation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognitive functioning
KW - distress
KW - suicidal ideation
KW - older primary care patients
KW - demographic characteristics
KW - clinical characteristics
KW - 2007
KW - Cognitive Ability
KW - Distress
KW - Geriatric Patients
KW - Primary Health Care
KW - Suicidal Ideation
KW - Clinics
KW - Demographic Characteristics
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: Herr, Elizabeth C. McDonel
U1 - Sponsor: US Department of Veterans Affairs, Health Resources and Services Administration, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Recipients: Arean, Patricia A.
DO - 10.1111/j.1532-5415.2007.01237.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10094-008&site=ehost-live&scope=site
UR - layalon@iit.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-06626-023
AN - 2007-06626-023
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Irie, Masahiro
AU - Fujioka, Yosei
AU - Haratani, Takashi
AU - Araki, Shunichi
T1 - Relationship between cumulative effects of smoking and memory CD4+ T lymphocyte subpopulations.
JF - Addictive Behaviors
JO - Addictive Behaviors
JA - Addict Behav
Y1 - 2007/07//
VL - 32
IS - 7
SP - 1526
EP - 1531
CY - Netherlands
PB - Elsevier Science
SN - 0306-4603
AD - Nakata, Akinori, National Institute for Occupational Safety and Health, MS-C24, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2007-06626-023. PMID: 17184930 Partial author list: First Author & Affiliation: Nakata, Akinori; National Institute for Occupational Safety and Health, Japan. Release Date: 20070528. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blood; Lymphocytes; Memory; Tobacco Smoking. Minor Descriptor: Leisure Time. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30). Location: Japan. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 2007.
AB - Previous studies have found that smoking is a strong factor that increases peripheral blood CD4+ T lymphocytes. However, most studies did not assess the cumulative long-life exposure of smoking on differential lymphocyte populations. In this study, to clarify the association of smoking habits and circulating lymphocytes, we conducted a cross-sectional study of 60 male current smokers. Smoking status was estimated by number of cigarettes smoked per day, smoking years, and Brinkman Index (BI) as calculated by multiplying the number of cigarettes smoked per day by the smoking years. Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (rp>.465, p<.001). These lymphocytes were also significantly correlated with the number of cigarettes smoked per day and smoking years, but the association was weaker than the BI. The findings suggest that the CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes are sensitive to cumulative effect of smoking, and may serve as a potential immuno-biomarker for active smoking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking
KW - memory
KW - blood CD4+ T lymphocytes
KW - leisure-time
KW - 2007
KW - Blood
KW - Lymphocytes
KW - Memory
KW - Tobacco Smoking
KW - Leisure Time
KW - 2007
DO - 10.1016/j.addbeh.2006.11.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-06626-023&site=ehost-live&scope=site
UR - nakataa-tky@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-09615-011
AN - 2007-09615-011
AU - Riegel, Arthur C.
AU - Zapata, Agustin
AU - Shippenberg, Toni S.
AU - French, Edward D.
T1 - The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2007/07//
VL - 32
IS - 7
SP - 1558
EP - 1569
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
AD - Riegel, Arthur C., Vollum Institute, Oregon Health & Sciences University, 3181 SW Sam Jackson Park Road, Mail Stop L474, Portland, OR, US, 85724-5050
N1 - Accession Number: 2007-09615-011. PMID: 17213847 Partial author list: First Author & Affiliation: Riegel, Arthur C.; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, US. Release Date: 20070910. Correction Date: 20100510. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Zapata, Agustin. Major Descriptor: Dopamine; Neurons; Neurotransmission; Nucleus Accumbens. Minor Descriptor: Inhalant Abuse; Rats; Tegmentum. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Jul, 2007.
AB - Recreational abuse of toluene-containing volatile inhalants by adolescents is a significant public health problem. The mechanisms underlying the abuse potential of such substances remain unclear, but could involve increased activity in mesoaccumbal dopamine (DA) afferents innervating the nucleus accumbens (ACB). Here, using in vitro electrophysiology, we show that application of behaviorally relevant concentrations of toluene directly stimulates DA neurons in the ventral tegmental area (VTA), but not surrounding midbrain regions. Toluene stimulation of VTA neurons persists when synaptic transmission is reduced. Moreover, unlike non-DA neurons, the magnitude of VTA DA neuron firing does not decline during longer exposures designed to emulate 'huffing'. Using dual-probe in vivo microdialysis, we show that perfusion of toluene directly into the VTA increases DA concentrations in the VTA (somatodendritic release) and its terminal projection site, the ACB. These results provide the first demonstration that even brief exposure to toluene increases action potential drive onto mesoaccumbal VTA DA neurons, thereby enhancing DA release in the ACB. The finding that toluene stimulates mesoaccumbal neurotransmission by activating VTA DA neurons directly (independently of transynaptic inputs) provide insights into the neural substrates that may contribute to the initiation and pathophysiology of toluene abuse. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - abused inhalant toluene
KW - mesoaccumbal dopamine
KW - nucleus accumbens
KW - ventral tegmental area
KW - neurons
KW - 2007
KW - Dopamine
KW - Neurons
KW - Neurotransmission
KW - Nucleus Accumbens
KW - Inhalant Abuse
KW - Rats
KW - Tegmentum
KW - 2007
U1 - Sponsor: National Institute on Drug Abuse. Grant: T-334180. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, Intramural Research Program. Recipients: Zapata, Agustin; Shippenberg, Toni S.
DO - 10.1038/sj.npp.1301273
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-09615-011&site=ehost-live&scope=site
UR - Riegela@OHSU.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12643-007
AN - 2007-12643-007
AU - Mukamel, Dana B.
AU - Spector, William D.
AU - Zinn, Jacqueline S.
AU - Huang, Lynn
AU - Weimer, David L.
AU - Dozier, Ann
T1 - Nursing homes' response to the nursing home compare report card.
JF - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JO - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JA - J Gerontol B Psychol Sci Soc Sci
Y1 - 2007/07//
VL - 62
IS - 4
SP - S218
EP - S225
CY - US
PB - Gerontological Society of America
SN - 1079-5014
SN - 1758-5368
AD - Mukamel, Dana B., Department of Medicine, Center for Health Policy Research, University of California, Irvine, 111 Academy, Suite 220, Irvine, CA, US, 92697-5800
N1 - Accession Number: 2007-12643-007. PMID: 17673535 Partial author list: First Author & Affiliation: Mukamel, Dana B.; Department of Medicine, University of California, Irvine, CA, US. Other Publishers: Oxford University Press. Release Date: 20071008. Correction Date: 20160912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Medicaid; Medicare; Nursing Homes; Psychological Report; Quality of Care. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2007.
AB - Objectives: The Centers for Medicare and Medicaid Services have recently begun publishing the Nursing Home Compare report card. The objective of this study was to examine the initial reactions of nursing homes to publication of the report card and to evaluate the impact of the report card on quality-improvement activities. Methods: We conducted a survey of a random national sample of 1,502 nursing home administrators; 724 responded. We analyzed frequency of responses to questions regarding views of the quality measures and actions taken. Results: A model of nursing homes' behavior predicted that the report card would provide an incentive for facilities to improve quality. A majority of facilities (69%) reported reviewing their quality scores regularly, and many have taken specific actions to improve quality. Homes with poor quality scores were more likely to take actions following the publication of the report card. Discussion: These findings suggest that the Nursing Home Compare report card has the potential to positively affect nursing home quality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nursing homes' response
KW - report card
KW - medicare
KW - medicaid services
KW - quality-improvement activities
KW - 2007
KW - Medicaid
KW - Medicare
KW - Nursing Homes
KW - Psychological Report
KW - Quality of Care
KW - 2007
U1 - Sponsor: National Institute on Aging, US. Grant: AG023177. Recipients: No recipient indicated
DO - 10.1093/geronb/62.4.S218
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12643-007&site=ehost-live&scope=site
UR - dmukamel@uci.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Chang, Wei-Tien
AU - Shao, Zuo-Hui
AU - Yin, Jun-Jie
AU - Mehendale, Sangeeta
AU - Wang, Chong-Zhi
AU - Qin, Yimin
AU - Li, Juan
AU - Chen, Wen-Jone
AU - Chien, Chiang-Ting
AU - Becker, Lance B.
AU - Vanden Hoek, Terry L.
AU - Yuan, Chun-Su
T1 - Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2007/07/02/
VL - 566
IS - 1-3
M3 - Article
SP - 58
EP - 66
SN - 00142999
AB - Abstract: Since flavonoids scavenge reactive oxygen species, they may potentially protect against ischemia/reperfusion injury. This study compared the scavenging capacity of specific flavonoids towards different reactive oxygen species. Whether the differential oxidant scavenging capacity correlated with their protective efficacy in ischemia/reperfusion injury of cardiomyocytes was determined. The free radical scavenging capacity of five flavonoids (wogonin, baicalin, baicalein, catechin and procyanidin B2) was analyzed using electron spin resonance spectrometry for 3 radicals: 1,1-diphenyl-2picrylhydrazyl (DPPH), superoxide and hydroxyl radical. A well-established chick cardiomyocyte model of ischemia (1 h)/reperfusion (3 h) was used to evaluate flavonoid-induced protection against ischemia/reperfusion injury in chronic treatment (pretreated 72 h and treated through ischemia/reperfusion) and acute treatment protocols (during ischemia/reperfusion or only at reperfusion). The cell viability was assessed by propidium iodide. The DPPH scavenging was most significant with catechin, followed by procyanidin B2, baicalein, baicalin, and wogonin. The superoxide scavenging was, similarly, most significant with catechin, followed by baicalein, procyanidin B2, and baicalin. For hydroxyl radical, only baicalein showed a significant scavenging capacity (>50% reduction in ESR signal). For the cardiomyocyte studies, all flavonoids but wogonin showed protection against ischemia/reperfusion injury in the chronic treatment protocol. When flavonoids were administered only during ischemia/reperfusion, baicalein, procyanidin B2, and catechin significantly reduced cell death. If flavonoids were administered just at reperfusion, only baicalein and procyanidin B2 had protective effects, and the efficacy was less. Flavonoids possess specific but differential radical scavenging capacity, which, in conjunction with the timing of treatment, affects their protective efficacy in cardiomyocytes exposed to ischemia/reperfusion. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISCHEMIA
KW - BLOOD circulation disorders
KW - SUPEROXIDES
KW - POLYPHENOLS
KW - Flavonoids
KW - Hydroxyl radical
KW - Reperfusion injury
KW - Scavenging capacity
KW - Superoxide
N1 - Accession Number: 25187349; Chang, Wei-Tien 1,2 Shao, Zuo-Hui 1 Yin, Jun-Jie 3 Mehendale, Sangeeta 4,5 Wang, Chong-Zhi 4,5 Qin, Yimin 1 Li, Juan 1 Chen, Wen-Jone 2 Chien, Chiang-Ting 6 Becker, Lance B. 1 Vanden Hoek, Terry L. 1 Yuan, Chun-Su 4,5; Email Address: cyuan@airway.uchicago.edu; Affiliation: 1: Emergency Resuscitation Center, Section of Emergency Medicine, Department of Medicine, University of Chicago, Chicago, IL, U.S.A. 2: Department of Emergency Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan, R.O.C. 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, U.S.A. 4: Tang Center for Herbal Medicine Research, United States 5: Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL, U.S.A. 6: Department of Medical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan, R.O.C.; Source Info: Jul2007, Vol. 566 Issue 1-3, p58; Subject Term: ISCHEMIA; Subject Term: BLOOD circulation disorders; Subject Term: SUPEROXIDES; Subject Term: POLYPHENOLS; Author-Supplied Keyword: Flavonoids; Author-Supplied Keyword: Hydroxyl radical; Author-Supplied Keyword: Reperfusion injury; Author-Supplied Keyword: Scavenging capacity; Author-Supplied Keyword: Superoxide; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ejphar.2007.03.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25187349&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gabel, Jon R.
AU - Whitmore, Heidi
AU - Pickreign, Jeremy D.
AU - Levit, Katharine R.
AU - Coffey, Rosanna M.
AU - Vandivort-Warren, Rita
T1 - Substance Abuse Benefits: Still Limited After All These Years.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/07/02/Jul2007 Supplement
VL - 26
IS - 4
M3 - Article
SP - w474
EP - w482
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Using data from a special supplement to the 2006 Kaiser/HRET Employer Health Benefits Survey, this study examines the state of employer-sponsored insurance substance abuse benefits in 2006 and how benefits compare to coverage for medical-surgical services. In 2006, 88 percent of insured workers had some coverage for substance abuse services. Current substance abuse benefits, however, do not provide the same protection afforded under medical-surgical benefits. Instead, substance abuse benefits are characterized by higher cost sharing and annual limits and lifetime limits on inpatient and outpatient care. These limits generally do not exist for other medical conditions and have increased since 1990. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH surveys
KW - EMPLOYEE assistance programs
KW - DRUG use testing
KW - PEOPLE with disabilities
KW - SUBSTANCE abuse
KW - PERSONALITY disorders
KW - COST control
KW - MENTAL health services
KW - MEDICAL care
N1 - Accession Number: 34485071; Gabel, Jon R. 1; Email Address: Gabel-Jon@NORC.org Whitmore, Heidi 2 Pickreign, Jeremy D. 3 Levit, Katharine R. 4 Coffey, Rosanna M. 5 Vandivort-Warren, Rita 6; Affiliation: 1: Senior Fellow, NORC in Washington, D. C. 2: Research Scientist, NORC in Plymouth,Minnesota 3: Research Scientist, NORC in Albany, New York 4: Senior Research Leader, Thomson Medstat in Washington, D. C. 5: Vice President 6: Senior Policy Analyst, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, in Rockville,Maryland; Source Info: Jul2007 Supplement, Vol. 26 Issue 4, pw474; Subject Term: HEALTH surveys; Subject Term: EMPLOYEE assistance programs; Subject Term: DRUG use testing; Subject Term: PEOPLE with disabilities; Subject Term: SUBSTANCE abuse; Subject Term: PERSONALITY disorders; Subject Term: COST control; Subject Term: MENTAL health services; Subject Term: MEDICAL care; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; Number of Pages: 9p; Document Type: Article
L3 - 10.1377/hlthaff.26.4.w474
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34485071&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buchmueller, Thomas C.
AU - Cooper, Philip F.
AU - Jacobson, Mireille
AU - Zuvekas, Samuel H.
T1 - Parity For Whom? Exemptions And The Extent Of State Mental Health Parity Legislation.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/07/02/Jul2007 Supplement
VL - 26
IS - 4
M3 - Article
SP - w483
EP - w487
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Between 1997 and 2003, the share of workers subject to mental health parity laws greatly increased. But because of exemptions for self-insured firms and small firms, coverage is much lower than a simple tally of state mandates would suggest. Limits on the types of conditions covered further weaken these laws. This paper summarizes the extent and scope of state parity legislation in terms of the number of insured private-sector employees covered. It explicitly accounts for the Employee Retirement Income Security Act (ERISA) exemption for self-insured plans, exemptions for small employers, and the range of conditions covered by the law. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEGISLATIVE bills
KW - MENTAL health policy
KW - EMPLOYEES
KW - EMPLOYERS
KW - RETIREMENT income
KW - INTERNATIONAL trusteeships
KW - SMALL business
KW - LEGISLATION
KW - PATHOLOGICAL psychology
N1 - Accession Number: 34485072; Buchmueller, Thomas C. 1; Email Address: tbuch@umich.edu Cooper, Philip F. 2 Jacobson, Mireille 2 Zuvekas, Samuel H. 3; Affiliation: 1: Professor, Ross School of Business, University of Michigan, AnnArbor 2: Senior Economists, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality (AHRQ),Rockville, Maryland 3: Assistant Professor, School of Social Ecology,University of California, Irvine; Source Info: Jul2007 Supplement, Vol. 26 Issue 4, pw483; Subject Term: LEGISLATIVE bills; Subject Term: MENTAL health policy; Subject Term: EMPLOYEES; Subject Term: EMPLOYERS; Subject Term: RETIREMENT income; Subject Term: INTERNATIONAL trusteeships; Subject Term: SMALL business; Subject Term: LEGISLATION; Subject Term: PATHOLOGICAL psychology; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 5p; Document Type: Article
L3 - 10.1377/hlthaff.26.4.w483
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34485072&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C.Ö.
AU - Esterhuizen, G.S.
AU - Schatzel, S.J.
AU - Diamond, W.P.
T1 - Reservoir simulation-based modeling for characterizing longwall methane emissions and gob gas venthole production
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2007/07/02/
VL - 71
IS - 2/3
M3 - Article
SP - 225
EP - 245
SN - 01665162
AB - Abstract: Longwall mining alters the fluid-flow-related reservoir properties of the rocks overlying and underlying an extracted panel due to fracturing and relaxation of the strata. These mining-related disturbances create new pressure depletion zones and new flow paths for gas migration and may cause unexpected or uncontrolled migration of gas into the underground workplace. One common technique to control methane emissions in longwall mines is to drill vertical gob gas ventholes into each longwall panel to capture the methane within the overlying fractured strata before it enters the work environment. Thus, it is important to optimize the well parameters, e.g., the borehole diameter, and the length and position of the slotted casing interval relative to the fractured gas-bearing zones. This paper presents the development and results of a comprehensive, “dynamic,” three-dimensional reservoir model of a typical multi-panel Pittsburgh coalbed longwall mine. The alteration of permeability fields in and above the panels as a result of the mining-induced disturbances has been estimated from mechanical modeling of the overlying rock mass. Model calibration was performed through history matching the gas production from gob gas ventholes in the study area. Results presented in this paper include a simulation of gas flow patterns from the gas-bearing zones in the overlying strata to the mine environment, as well as the influence of completion practices on optimizing gas production from gob gas ventholes. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - LONGWALL mining
KW - AIR conditioning
KW - DAMPNESS in buildings
KW - Gob gas ventholes
KW - Longwall mining
KW - Reservoir modeling
KW - Reservoir simulation
KW - Ventilation
N1 - Accession Number: 24968535; Karacan, C.Ö.; Email Address: cok6@cdc.gov Esterhuizen, G.S. 1 Schatzel, S.J. 1 Diamond, W.P. 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, United States; Source Info: Jul2007, Vol. 71 Issue 2/3, p225; Subject Term: COAL mines & mining; Subject Term: LONGWALL mining; Subject Term: AIR conditioning; Subject Term: DAMPNESS in buildings; Author-Supplied Keyword: Gob gas ventholes; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Reservoir modeling; Author-Supplied Keyword: Reservoir simulation; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.coal.2006.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=24968535&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kochman, Sheryl A.
T1 - Role of the Food and Drug Administration in the use of molecular techniques in immunohematology.
JO - Transfusion
JF - Transfusion
Y1 - 2007/07/02/Jul2007 Supplement
VL - 47
M3 - Article
SP - 3S
EP - 9S
PB - Wiley-Blackwell
SN - 00411132
AB - The article discusses the role of U.S. Food and Drug Administration (FDA) in the use of molecular testing of immunohematology. The agency is concerned about several problems including the weak activity of clinically significant antibodies, weak expression of red blood cells (RBC) antigens and the lack of universal test methods for antibody detection and identification.
KW - IMMUNOHEMATOLOGY
KW - IMMUNOLOGY
KW - IMMUNOGLOBULINS
KW - COMPATIBILITY testing (Hematology)
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 25427433; Kochman, Sheryl A. 1; Email Address: sheryl.kochman@fda.hhs.gov; Affiliation: 1: Devices Review Branch, Division of Blood Applications, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration; Source Info: Jul2007 Supplement, Vol. 47, p3S; Subject Term: IMMUNOHEMATOLOGY; Subject Term: IMMUNOLOGY; Subject Term: IMMUNOGLOBULINS; Subject Term: COMPATIBILITY testing (Hematology); Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/j.1537-2995.2007.01303.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105845935
T1 - Role of the Food and Drug Administration in the use of molecular techniques in immunohematology.
AU - Kochman SA
Y1 - 2007/07/02/Jul2007 Supplement
N1 - Accession Number: 105845935. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Jul2007 Supplement. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Cytogenetic Analysis -- Utilization
KW - Hematology -- Legislation and Jurisprudence
KW - Hematology -- Methods
KW - United States Food and Drug Administration
KW - Allergy and Immunology -- Legislation and Jurisprudence
KW - Immunologic Techniques
KW - Practice Guidelines
KW - United States
SP - 3S
EP - 9S
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 47
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Devices Review Branch, Division of Blood Applications, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-390, 1401 Rockville Pike, Rockville, MD 20852-1448; sheryl.kochman@fda.hhs.gov
U2 - PMID: 17593279.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pritchard, G. C.
AU - Marshall, J. A.
AU - Giles, M.
AU - Chalmers, R. M.
AU - Marshall, R. N.
T1 - Cryptosporidium parvum infection in orphan lambs on a farm open to the public.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2007/07/07/
VL - 161
IS - 1
M3 - Article
SP - 11
EP - 14
SN - 00424900
AB - A longitudinal survey was undertaken on an open farm to investigate the occurrence of Cryptosporidium species infection in orphan lambs obtained from three local flocks. During an initial pilot study, Cryptosporidium oocysts were detected by a fluorescent antibody test (FAT) in the faeces of two of 21 lambs aged between one and three weeks derived from one flock (flock A). Pooled pen samples of faeces were collected weekly from lambs derived from each flock; oocysts were detected by FAT in 24 (49.0 per cent) of 49 samples from lambs from flock A, 18 (30.5 per cent) of 59 samples from lambs from flock B and 14 (29.8 per cent) of 47 samples from lambs from flock C. Oocyst counts of 1 × 103 to more than 2 × 106 per gram of faeces were detected in lambs up to 12 weeks old, with the peak counts occurring at six weeks of age in the lambs from flocks A and B and at four weeks of age in those from flock C. The oocysts were confirmed by molecular analysis as Cryptosporidium porvum. Virtually all the infections were subclinical. [ABSTRACT FROM AUTHOR]
AB - Copyright of Veterinary Record: Journal of the British Veterinary Association is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM
KW - CRYPTOSPORIDIIDAE
KW - INFECTION
KW - LAMBS
KW - FLUORESCENT antibody technique
N1 - Accession Number: 25972309; Pritchard, G. C. 1 Marshall, J. A. Giles, M. Chalmers, R. M. 2 Marshall, R. N.; Affiliation: 1: Veterinary Laboratories Agency (VLA) - Bury St Edmunds, Rougham Hill, Bury St Edmunds 1P33 2RX 2: Cryptosporidium Reference Unit, National Public Health Service Microbiology Swansea, Singleton Hospital, Swansea SA2 8QA; Source Info: 7/7/2007, Vol. 161 Issue 1, p11; Subject Term: CRYPTOSPORIDIUM; Subject Term: CRYPTOSPORIDIIDAE; Subject Term: INFECTION; Subject Term: LAMBS; Subject Term: FLUORESCENT antibody technique; Number of Pages: 4p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Eun-Sook
AU - Sohn, Yeo-Won
AU - Moon, Aree
T1 - TGF-β-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2007/07/08/
VL - 252
IS - 1
M3 - Article
SP - 147
EP - 156
SN - 03043835
AB - Abstract: We have previously shown that transforming growth factor (TGF)-β up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-β in MCF10A cells. By using 5′ deletion constructs of MMP-2 promoter, we demonstrated that binding sites for p53, S1, AP-1 and Sp1, and to a lesser extent CREB, GCN-His and PEA3, were potential cis-acting elements for TGF-β-induced transcriptional activation of MMP-2 in MCF10A cells. Since activating transcription factor (ATF)2 was shown to mediate the TGF-β-induced cellular responses, we examined the involvement of ATF2 in TGF-β-activated MMP-2 gene transcription. TGF-β increased DNA binding activity of AP-1 in which ATF2 was involved as evidenced by electrophoretic mobility shift assay. TGF-β induced phosphorylation of ATF2 through p38 MAPK signaling. A dominant-negative (DN) ATF2 significantly inhibited the TGF-β-induced up-regulation of MMP-2, but not that of MMP-9, suggesting that ATF2 may be a transcription factor responsible for transcriptional activation of MMP-2 gene by TGF-β. Invasive and migratory phenotypes induced by TGF-β were significantly inhibited by DN ATF2, indicating a critical role of ATF2 in TGF-β-induced oncogenic progression of MCF10A cells. Taken together, this study demonstrates that ATF2 mediates the TGF-β-induced MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-β. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFORMING growth factors
KW - METALLOPROTEINASES
KW - EPITHELIAL cells
KW - GENETIC transcription
KW - AP-1
KW - ATF2
KW - Breast epithelial cells
KW - MMP
KW - p38 MAPK
KW - TGF-β
N1 - Accession Number: 25107504; Kim, Eun-Sook 1 Sohn, Yeo-Won 2 Moon, Aree 1; Email Address: armoon@duksung.ac.kr; Affiliation: 1: College of Pharmacy, Duksung Women’s University, Seoul 132-714, Republic of Korea 2: Biologics Headquarters, Korea Food and Drug Administration, Seoul 122-020, Republic of Korea; Source Info: Jul2007, Vol. 252 Issue 1, p147; Subject Term: TRANSFORMING growth factors; Subject Term: METALLOPROTEINASES; Subject Term: EPITHELIAL cells; Subject Term: GENETIC transcription; Author-Supplied Keyword: AP-1; Author-Supplied Keyword: ATF2; Author-Supplied Keyword: Breast epithelial cells; Author-Supplied Keyword: MMP; Author-Supplied Keyword: p38 MAPK; Author-Supplied Keyword: TGF-β; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.canlet.2006.12.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wysowshi, Diane K.
AU - Nourjah, Parivash
AU - Swartz, Lynette
T1 - Bleeding Complications With Warfarin Use.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2007/07/09/
VL - 167
IS - 13
M3 - Article
SP - 1414
EP - 1419
SN - 00039926
AB - The article analyzes data concerning the use of warfarin and its prevalence of bleeding complications in the United States to support a requirement by the Food and Drug Administration for a boxed warning in the professional product information and for a patient Medication Guide. Warfarin use has increased, and bleeding from warfarin use is a prevalent reaction and an important cause of mortality.
KW - WARFARIN
KW - HEMORRHAGE
KW - WARNING labels
KW - COUMARINS
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 25885850; Wysowshi, Diane K. 1; Email Address: wysowski@fda.hhs.gov Nourjah, Parivash 1 Swartz, Lynette 1; Affiliation: 1: Office of Surveillance and Epidemiology Food and Drug Administration, Silver Spring, Maryland; Source Info: 7/9/2007, Vol. 167 Issue 13, p1414; Subject Term: WARFARIN; Subject Term: HEMORRHAGE; Subject Term: WARNING labels; Subject Term: COUMARINS; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Azurmendi, Hugo F.
AU - Vionnet, Justine
AU - Wrightson, Lauren
AU - Trinh, Loc B.
AU - Shiloach, Joseph
AU - Freedberg, Darón I.
T1 - Extracellular structure of polysialic acid explored by on cell solution NMR.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2007/07/10/
VL - 104
IS - 28
M3 - Article
SP - 11557
EP - 11561
SN - 00278424
AB - The capsular polysaccharide of the pathogens Neisseria meningitidis serogroup B and of Escherichia coil K1, α(2→8) polysialic acid (PSA), is unusual, because when injected into adult humans, it generates little or no antibody. In contrast, people infected with these pathogens generate specific serum antibodies. A structural study on cells is used to address this anomaly by characterizing antigen structures in vivo. We introduce on cell multidimensional solution NMR spectroscopy for direct observation of PSA on E. coil bacteria. Using 13C,15N-labeled PSA, we applied a combination of heteronuclear NMR methods, such as heteronuclear single quan- tum coherence, HNCA, and HNCO, in vivo. Analysis reveals that free and cell-bound PSA are structurally similar, indicating that the poor immunogenicity of PSA is not due to major structural differences between cells and purified PSA. The 13C linewidths of PSA on cells are 2 to 3 times larger than the corresponding ones in free PSA. The possible implications of the differences between free and on cell PSA are discussed. In addition, we demonstrate the suitability of the method for in vivo kinetic studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance
KW - POLYSACCHARIDES
KW - PATHOGENIC microorganisms
KW - NEISSERIA meningitidis
KW - ENTEROBACTERIACEAE
KW - ESCHERICHIA
KW - carbohydrate structure
KW - in vivo kinetics
KW - isotopically labeled carbohydrates
KW - triple resonance NMR
N1 - Accession Number: 25824162; Azurmendi, Hugo F. 1 Vionnet, Justine 1 Wrightson, Lauren 1 Trinh, Loc B. 2 Shiloach, Joseph 2 Freedberg, Darón I. 1; Email Address: daron.freedberg@fda.hhs.gov; Affiliation: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448 2: Biotechnology Unit, MSC 5522, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 7/10/2007, Vol. 104 Issue 28, p11557; Subject Term: NUCLEAR magnetic resonance; Subject Term: POLYSACCHARIDES; Subject Term: PATHOGENIC microorganisms; Subject Term: NEISSERIA meningitidis; Subject Term: ENTEROBACTERIACEAE; Subject Term: ESCHERICHIA; Author-Supplied Keyword: carbohydrate structure; Author-Supplied Keyword: in vivo kinetics; Author-Supplied Keyword: isotopically labeled carbohydrates; Author-Supplied Keyword: triple resonance NMR; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1073/pnas.0704404104
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Itai Chipinda
AU - Justin M. Hettick
AU - Reuben H. Simoyi
AU - Paul D. Siegel
T1 - Oxidation of 2-Mercaptobenzothiazole in Latex Gloves and Its Possible Haptenation Pathway.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2007/07/12/
VL - 20
M3 - Article
SP - 1084
EP - 1092
SN - 0893228X
AB - The rubber accelerator, 2-mercaptobenzothiazole (MBT), has been reported to cause allergic contact dermatitis from gloves and other rubber products, but its chemical fate when exposed to occupational oxidants and the mechanism of its pathogenesis are not known. It was hypothesized that the thiol group is critical to MBT’s (its oxidation products or metabolites) covalent binding and/or haptenation to nucleophilic protein residues. Oxidative transformation of MBT to the disulfide 2,2′-dithiobis(benzothiazole) (MBTS) was observed within the glove matrix when hypochlorous acid, iodine, and hydrogen peroxide were used as oxidants. Cysteine reduced MBTS to MBT with subsequent formation of the mixed disulfide 2-amino-3-(benzothiazol-2-yl disulfanyl)propionic acid which was identified and characterized. Spectrophotometry and mass spectrometry experiments demonstrated the simultaneous reduction of MBTS and disulfide formation with Cys34 on bovine serum albumin, suggesting a potential route of protein haptenation through covalent bonding between protein cysteinyl residues and the MBT/MBTS thiol moiety. Metabolism of MBT using isoniazid and dexamethasone-induced rat liver microsomes, to give a protein reactive epoxide intermediate and provide an alternative protein haptenation mechanism, was not observed. The data suggest that the critical functional group on MBT is the thiol, and haptenation is via the formation of mixed disulfides between the thiol group on MBT and a protein sulfhydryl group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Research in Toxicology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - DISINFECTION & disinfectants
KW - OXIDIZING agents
KW - BIOLOGICAL products
N1 - Accession Number: 26588039; Itai Chipinda 1 Justin M. Hettick 1 Reuben H. Simoyi 1 Paul D. Siegel 1; Affiliation: 1: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, and Department of Chemistry, Portland State University, Portland, Oregon 97201-0751; Source Info: Jul2007, Vol. 20, p1084; Subject Term: SKIN -- Inflammation; Subject Term: DISINFECTION & disinfectants; Subject Term: OXIDIZING agents; Subject Term: BIOLOGICAL products; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106163485
T1 - Impact of mobile radiographic screening on tuberculosis among drug users and homeless persons.
AU - de Vries G
AU - van Hest RA
AU - Richardus JH
Y1 - 2007/07/15/
N1 - Accession Number: 106163485. Language: English. Entry Date: 20071005. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 9421642.
KW - Health Screening -- Methods
KW - Homeless Persons
KW - Mobile Health Units
KW - Substance Abusers
KW - Tuberculosis, Pulmonary -- Diagnosis
KW - Adult
KW - Aged
KW - Data Analysis Software
KW - DNA Fingerprinting
KW - Female
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Mycobacterium
KW - Netherlands
KW - Odds Ratio
KW - Radiography, Thoracic
KW - Tuberculosis, Pulmonary -- Epidemiology
KW - Tuberculosis, Pulmonary -- Familial and Genetic
KW - Tuberculosis, Pulmonary -- Radiography
KW - Tuberculosis, Pulmonary -- Transmission
KW - Univariate Statistics
KW - Human
SP - 201
EP - 207
JO - American Journal of Respiratory & Critical Care Medicine
JF - American Journal of Respiratory & Critical Care Medicine
JA - AM J RESPIR CRIT CARE MED
VL - 176
IS - 2
CY - New York, New York
PB - American Thoracic Society
AB - Rationale: In 2002, a mobile radiographic screening program was started in Rotterdam to respond to high rates of tuberculosis (TB) among illicit drug users and homeless persons. Objectives: We studied trends and characteristics of TB among these risk groups and assessed the impact of the screening program on transmission, using molecular typing. Methods: Description of trends, and of demographic and disease-related characteristics of tuberculosis cases among these risk groups between 1993 and 2005. TB was considered to result from recent transmission if the mycobacterial DNA fingerprints of cases were identical to those of other cases in the risk groups in the previous 2 years. Measurements and Main Results: During the study period, 206 individuals with TB among illicit drug users and homeless persons were notified, representing 11.4% of the total case load of 1,811 in Rotterdam. The annual number of tuberculosis cases declined from 24 at the start of the screening program to 11 cases in 2005. The screening program identified 28 cases (a prevalence rate of 327 per 100,000 radiographs), of which 12 were smear positive. In 1997-2002, more than 80% of the illicit drug users or homeless persons with TB were infected with one of the Mycobacterium tuberculosis strains prevalent among these risk groups. After nearly 4 years of systematic radiographic screening this proportion declined to 45% in 2005. Conclusions: DNA fingerprinting can be a useful tool to evaluate the impact of a TB screening program. We advocate that screening of illicit drug users and homeless persons should be continued to prevent a resurgence of TB.
SN - 1073-449X
AD - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands. devriesg@ggd.rotterdam.nl.
U2 - PMID: 17413123.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Manger, Ronald
AU - Woodle, Doug
AU - Berger, Andrew
AU - Hungerford, James
T1 - Flow cytometric detection of saxitoxins using fluorescent voltage-sensitive dyes
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2007/07/15/
VL - 366
IS - 2
M3 - Article
SP - 149
EP - 155
SN - 00032697
AB - Abstract: By virtue of their ability to block depolarization of nerve cells, the saxitoxins exert the toxic effects associated with paralytic shellfish poisoning and allow for their detection through various methodologies. When veratridine-induced depolarization is followed using voltage-sensitive fluorescent dyes, the presence of these toxic blocking agents can be observed as a decrease in fluorescence of dye-treated nerve cells. Detection using flow cytometry provides for selection of the most responsive population of cultured mouse neuroblastoma (Neuro 2a) cells thereby enhancing assay sensitivity and this approach can be accomplished in real time. The method is demonstrated in preliminary studies using saxitoxin and crude shellfish extracts. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARALYTIC shellfish poisoning
KW - NEUROTOXIC agents
KW - TUMORS in children
KW - AQUATIC invertebrates
KW - Flow cytometry
KW - Neuroblastoma
KW - Saxitoxins
KW - Voltage-sensitive dyes
N1 - Accession Number: 25407468; Manger, Ronald 1; Email Address: rmanger@fhcrc.org Woodle, Doug 1 Berger, Andrew 1 Hungerford, James 2; Affiliation: 1: Fred Hutchinson Cancer Research Center, Biologics Production Facility, Seattle, WA 98109, USA 2: Food and Drug Administration, Seafood Products Research Center, Bothell, WA 98041, USA; Source Info: Jul2007, Vol. 366 Issue 2, p149; Subject Term: PARALYTIC shellfish poisoning; Subject Term: NEUROTOXIC agents; Subject Term: TUMORS in children; Subject Term: AQUATIC invertebrates; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: Neuroblastoma; Author-Supplied Keyword: Saxitoxins; Author-Supplied Keyword: Voltage-sensitive dyes; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ab.2007.04.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Kenneth C.
AU - Hannah, Alison L.
AU - Pazdur, Richard
AU - Farrell, Ann T.
T1 - A strategic framework for novel drug development in multiple myeloma.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/07/15/
VL - 138
IS - 2
M3 - Article
SP - 153
EP - 159
PB - Wiley-Blackwell
SN - 00071048
AB - Although multiple myeloma remains incurable, recent advances in research have created a new paradigm for the development of novel agents for myeloma treatment. Biological insights are being translated rapidly from bench to bedside, with an increasing number of agents available at all stages of disease. Concomitantly, the drug development and approval process has become more challenging. Defining optimal clinical dosing schedules and therapeutic regimens is increasingly dependent on insights derived from genomic, proteomic and cell signaling studies. Because the maximum tolerated dose of a novel agent may not be the same as the optimal biological dose, designing phase I trials is more complex. Evaluation of new agents in patients who have relapsed is more challenging because the number of effective therapies has increased. Finally, choosing a ‘standard therapy’ control arm for randomised trials is more difficult because of the increased number of potential comparator regimens. In June 2005, the Multiple Myeloma Research Foundation (MMRF) sponsored a roundtable symposium in Washington, DC, to define the strategies and guidelines for phases I, II and III development of new myeloma agents, with the ultimate goal of speeding delivery of new therapies to myeloma patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIPLE myeloma
KW - CANCER treatment
KW - DRUG development
KW - DRUG approval
KW - THERAPEUTICS
KW - CLINICAL trials
KW - accelerated approval
KW - multiple myeloma
KW - surrogate biomarker studies
N1 - Accession Number: 25511475; Anderson, Kenneth C. 1; Email Address: kenneth_anderson@dfci.harvard.edu Hannah, Alison L. 2 Pazdur, Richard 3 Farrell, Ann T. 4; Affiliation: 1: Department of Medicine, Harvard Medical School, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, MA 2: Consultant Industry, Sebastopol, CA 3: Office of Oncology Drug Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 4: Division of Drug Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA; Source Info: Jul2007, Vol. 138 Issue 2, p153; Subject Term: MULTIPLE myeloma; Subject Term: CANCER treatment; Subject Term: DRUG development; Subject Term: DRUG approval; Subject Term: THERAPEUTICS; Subject Term: CLINICAL trials; Author-Supplied Keyword: accelerated approval; Author-Supplied Keyword: multiple myeloma; Author-Supplied Keyword: surrogate biomarker studies; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06641.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rios, Maria
AU - Daniel, Sylvester
AU - Chancey, Caren
AU - Hewlett, Indira K.
AU - Stramer, Susan L.
T1 - West Nile Virus Adheres to Human Red Blood Cells in Whole Blood.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/07/15/
VL - 45
IS - 2
M3 - Article
SP - 181
EP - 186
SN - 10584838
AB - Background. West Nile virus (WNV) is endemic in the United States. It is transmissible by blood transfusion, and the nation's blood supply is currently screened for WNV. Documented transmission of WNV infection through red blood cell (RBC) units in which the plasma co-component had a low viral load could be explained, in at least 1 instance, by cell-association of WNV; in this case, the RBC unit was released as negative by minipool nucleic acid testing (NAT) performed on plasma but was intermittently NAT-positive when subsequently tested as an individual sample. We hypothesized that a proportion of WNV bound to blood cells and was not measured by NAT performed on plasma samples. We have investigated whether WNV binds to RBCs, leading to reduction of WNV RNA detection by NAT performed on plasma samples. Methods. Equal volumes of leukoreduced RBCs and their corresponding plasma components from 20 blood donors with NAT results that were positive for WNV were tested in 5 replicates by reverse-transcriptase polymerase chain reaction TaqMan for WNV. In addition, aliquots from 8 of the RBC units were tested by infectivity assays using Vero cells. Results. The reverse-transcriptase polymerase chain reaction TaqMan assay showed that the viral load in the RBC components exceeded that in the corresponding plasma units by 1 order of magnitude. In addition, viruses associated with the RBCs were infectious in Vero cell cultures. Conclusions. These observations reinforce the notion that extraction of viral RNA from whole blood could improve assay sensitivity for blood donor screening and further reduce the residual risk of WNV transmission through transfusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - West Nile virus
KW - Blood transfusion
KW - Erythrocytes
KW - Cell culture
KW - United States
N1 - Accession Number: 25486997; Rios, Maria 1; Email Address: Maria.Rios@fda.hhs.gov; Daniel, Sylvester 1; Chancey, Caren 1; Hewlett, Indira K. 1; Stramer, Susan L. 2; Affiliations: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda.; 2: American Red Cross, Gaithersburg, Maryland.; Issue Info: 7/15/2007, Vol. 45 Issue 2, p181; Thesaurus Term: West Nile virus; Subject Term: Blood transfusion; Subject Term: Erythrocytes; Subject Term: Cell culture; Subject: United States; Number of Pages: 6p; Document Type: Article
L3 - 10.1086/518850
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sugase-Miyamoto, Yasuko
AU - Richmond, Barry J.
T1 - Cue and reward signals carried by monkey entorhinal cortex neurons during reward schedules.
JO - Experimental Brain Research
JF - Experimental Brain Research
Y1 - 2007/07/15/
VL - 181
IS - 2
M3 - Article
SP - 267
EP - 276
SN - 00144819
AB - Ablation of entorhinal/perirhinal cortices prevents learning associations between visual stimuli used as cues in reward schedules and the schedule state. Single neurons in perirhinal cortex are sensitive to associations between the cues and the reward schedules. To investigate whether neurons in the entorhinal cortex have similar sensitivities, we recorded single neuronal activity from two rhesus monkeys while the monkeys performed a visually cued reward schedule task. When the cue was related to the reward schedules, the monkeys made progressively fewer errors as the schedule state became closer to the reward state, showing that the monkeys were sensitive to the cue and the schedule state. Of 75 neurons recorded in the entorhinal cortex during task performance, about 30% responded. About half of these responded after cue presentation. When the relation of the cue to the reward schedules was random, the cue-related responses disappeared or lost their selectivity for schedule states. The responses of the entorhinal cortex neurons are similar to responses of perirhinal cortex neurons in that they are selective for the associative relationships between cues and reward schedules. However, they are particularly selective for the first trial of a new schedule, in contrast to perirhinal cortex where responsivity to all schedule states is seen. A different subpopulation of entorhinal neurons responded to the reward, unlike perirhinal neurons which respond solely to the cue. These results indicate that the entorhinal signals carry associative relationships between the visual cues and reward schedules, and between rewards and reward schedules that are not simply derived from perirhinal cortex by feed-forward serial processing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Brain Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROPHYSIOLOGY
KW - HIGHER nervous activity
KW - NEURAL transmission
KW - NEURAL conduction
KW - NEUROLOGY
KW - Association
KW - Macaque
KW - Motivation
KW - Neurophysiology
KW - Temporal lobe
N1 - Accession Number: 25654342; Sugase-Miyamoto, Yasuko 1,2,3 Richmond, Barry J. 1; Email Address: bjr@ln.nimh.nih.gov; Affiliation: 1: Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-4415, USA 2: Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba 305-8568, Japan 3: JSPS Overseas Research Fellow, Japan Society for the Promotion of Science, 1-6 Chiyoda-ku, Tokyo 102-8471, Japan; Source Info: Jul2007, Vol. 181 Issue 2, p267; Subject Term: NEUROPHYSIOLOGY; Subject Term: HIGHER nervous activity; Subject Term: NEURAL transmission; Subject Term: NEURAL conduction; Subject Term: NEUROLOGY; Author-Supplied Keyword: Association; Author-Supplied Keyword: Macaque; Author-Supplied Keyword: Motivation; Author-Supplied Keyword: Neurophysiology; Author-Supplied Keyword: Temporal lobe; Number of Pages: 10p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1007/s00221-007-0926-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Dong, Jennie H.
AU - Wu, John Z.
AU - Rakheja, Subhash
T1 - Modeling of biodynamic responses distributed at the fingers and the palm of the human hand–arm system
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2007/07/15/
VL - 40
IS - 10
M3 - Article
SP - 2335
EP - 2340
SN - 00219290
AB - Abstract: The objective of this study is to develop analytical models for simulating driving-point biodynamic responses distributed at the fingers and palm of the hand under vibration along the forearm direction (z h-axis). Two different clamp-like model structures are formulated to analyze the distributed responses at the fingers–handle and palm–handle interfaces, as opposed to the single driving point invariably considered in the reported models. The parameters of the proposed four- and five degrees-of-freedom models are identified through minimization of an rms error function of the model and measured responses under different hand actions, namely, fingers pull, push only, grip only, and combined push and grip. The results show that the responses predicted from both models agree reasonably well with the measured data in terms of distributed as well total impedance magnitude and phase. The variations in the identified model parameters under different hand actions are further discussed in view of the biological system behavior. The proposed models are considered to serve as useful tools for design and assessment of vibration isolation methods, and for developing a hand–arm simulator for vibration analysis of power tools. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAND
KW - FINGERS
KW - HUMAN physiology
KW - HUMAN body
KW - Biodynamic response
KW - Finger
KW - Hand
KW - Hand–arm vibration
KW - Hand-transmitted vibration
N1 - Accession Number: 25596417; Dong, Ren G. 1; Email Address: rkd6@cdc.gov Dong, Jennie H. 2 Wu, John Z. 1 Rakheja, Subhash 2; Affiliation: 1: Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Department of Mechanical Engineering, Concordia University, 1455 de Maisoneuve Boulevard, W. Montreal, Canada H3G 1M8; Source Info: Jul2007, Vol. 40 Issue 10, p2335; Subject Term: HAND; Subject Term: FINGERS; Subject Term: HUMAN physiology; Subject Term: HUMAN body; Author-Supplied Keyword: Biodynamic response; Author-Supplied Keyword: Finger; Author-Supplied Keyword: Hand; Author-Supplied Keyword: Hand–arm vibration; Author-Supplied Keyword: Hand-transmitted vibration; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jbiomech.2006.10.031
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Warren, Gordon L.
AU - Summan, Mukesh
AU - Gao, Xin
AU - Chapman, Rebecca
AU - Hulderman, Tracy
AU - Simeonova, Petia P.
T1 - Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse models.
JO - Journal of Physiology
JF - Journal of Physiology
Y1 - 2007/07/15/
VL - 582
IS - 2
M3 - Article
SP - 825
EP - 841
SN - 00223751
AB - Common acute injuries to skeletal muscle can lead to significant pain and disability. The current therapeutic approaches for treating muscle injuries are dependent on the clinical severity but not on the type of injury. In the present studies, the pathophysiology and molecular pathways associated with two different types of skeletal muscle injury, one induced by direct destruction of muscle tissue (i.e. FI) and the other induced by a contractile overload (more specifically high-force eccentric contractions, i.e. CI) were compared side by side. Histopathological evaluation and measurements of muscle strength were accompanied by analyses of expression for 12 488 known genes at four time points ranging from 6 h to 7 days after injury. Real-time RT-PCR was used to confirm some of the injury type differences in the temporal profiles of gene expression. Our data revealed several pools of genes, including early induction of transcription, myogenic and stress-responsive factors, common for both types of injury as well as pools of genes expressed specifically with one of the injury types. Only CI activated a set of genes associated with the repair of impaired proteins and structures including genes related to apoptosis, whereas FI uniquely activated gene sets involved in extensive inflammatory responses, tissue remodelling, angiogenesis and myofibre/extracellular matrix synthesis. In conclusion, knowledge of the sets of genes associated specifically with the nature of the injury may have application for development of new strategies for acceleration of the recovery process in injured skeletal muscle. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Physiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 25617113; Warren, Gordon L. 1 Summan, Mukesh 2 Gao, Xin 2 Chapman, Rebecca 2 Hulderman, Tracy 2 Simeonova, Petia P. 2; Affiliation: 1: Division of Physical Therapy, Georgia State University, Atlanta GA 30303, USA 2: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Jul2007, Vol. 582 Issue 2, p825; Number of Pages: 17p; Illustrations: 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1113/jphysiol.2007.132373
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25617113&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moffit, Jeffrey S.
AU - Koza-Taylor, Petra H.
AU - Holland, Ricky D.
AU - Thibodeau, Michael S.
AU - Beger, Richard D.
AU - Lawton, Michael P.
AU - Manautou, José E.
T1 - Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/07/15/
VL - 222
IS - 2
M3 - Article
SP - 169
EP - 179
SN - 0041008X
AB - Abstract: Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPARα) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPARα-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPARα-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring® software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC–ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - PEROXISOMES
KW - CLOFIBRATE
KW - HEPATOTOXICOLOGY
KW - Acetaminophen
KW - Clofibrate
KW - Cystamine
KW - Cysteamine
KW - Hepatoprotection
KW - Pantetheine
KW - Pantothenic acid
KW - Peroxisome proliferators
KW - Vanin-1
N1 - Accession Number: 25952235; Moffit, Jeffrey S. 1 Koza-Taylor, Petra H. 2 Holland, Ricky D. 3 Thibodeau, Michael S. 1 Beger, Richard D. 3 Lawton, Michael P. 2 Manautou, José E. 1; Email Address: jose.manautou@uconn.edu; Affiliation: 1: University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT, USA 2: Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT, USA 3: National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR, USA; Source Info: Jul2007, Vol. 222 Issue 2, p169; Subject Term: GENE expression; Subject Term: PEROXISOMES; Subject Term: CLOFIBRATE; Subject Term: HEPATOTOXICOLOGY; Author-Supplied Keyword: Acetaminophen; Author-Supplied Keyword: Clofibrate; Author-Supplied Keyword: Cystamine; Author-Supplied Keyword: Cysteamine; Author-Supplied Keyword: Hepatoprotection; Author-Supplied Keyword: Pantetheine; Author-Supplied Keyword: Pantothenic acid; Author-Supplied Keyword: Peroxisome proliferators; Author-Supplied Keyword: Vanin-1; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2007.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guirguis-Blake, Janelle
AU - Calonge, Ned
AU - Miller, Therese
AU - Siu, Albert
AU - Teutsch, Steven
AU - Whitlock, Evelyn
T1 - Current Processes of the U.S. Preventive Services Task Force: Refining Evidence-Based Recommendation Development.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/07/17/
VL - 147
IS - 2
M3 - Article
SP - 117
EP - W17
SN - 00034819
AB - The U.S. Preventive Services Task Force (USPSTF), an independent panel that has provided the gold standard for evidence-based guidelines in prevention for the past 2 decades, continuously refines its methodology. To keep up with the evolving field of evidence-based medicine and to update recommendations in a timely, efficient, and transparent manner, the USPSTF has developed new methods for evidence reviews and recommendation development. This article summarizes the most recent changes in the recommendation development process, including how the USPSTF solicits and prioritizes topics for review, updates evidence reviews and recommendations, and communicates with its audience. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EVIDENCE-based medicine
KW - DECISION making in clinical medicine
KW - MEDICAL policy
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 25782586; Guirguis-Blake, Janelle 1 Calonge, Ned 1 Miller, Therese 1 Siu, Albert 1 Teutsch, Steven 1 Whitlock, Evelyn 1; Affiliation: 1: U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 7/17/2007, Vol. 147 Issue 2, p117; Subject Term: EVIDENCE-based medicine; Subject Term: DECISION making in clinical medicine; Subject Term: MEDICAL policy; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barton, Mary B.
AU - Miller, Therese
AU - Wolff, Tracy
AU - Petitti, Diana
AU - LeFevre, Michael
AU - Sawaya, George
AU - Yawn, Barbara
AU - Guirguis-Blake, Janelle
AU - Calonge, Ned
AU - Harris, Russell
T1 - How to Read the New Recommendation Statement: Methods Update from the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/07/17/
VL - 147
IS - 2
M3 - Article
SP - 123
EP - W18
SN - 00034819
AB - Since 2001, the U.S. Preventive Services Task Force (USPSTF) has worked to refine its methods of evidence review and assessment and to create more usable documents in response to clinicians' needs. These changes have resulted in a revised grading system, as well as a new format and new language for the recommendation statement. This paper focuses on the changes to and the new look of the USPSTF recommendation statement. The new recommendation statement comprises 9 sections. Important changes include standardization of the format of the summary statement to specify what service is being recommended in what population; standardization of the headings in the rationale section; a change in the wording of the grade C recommendation and the I statement; and a new section, called ‘Other Considerations,’ in which salient issues related to cost-effectiveness, mandates, and other implementation issues are described. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL policy
KW - EVIDENCE-based medicine
KW - DECISION making in clinical medicine
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 25782587; Barton, Mary B. 1 Miller, Therese 1 Wolff, Tracy 1 Petitti, Diana 1 LeFevre, Michael 1 Sawaya, George 1 Yawn, Barbara 1 Guirguis-Blake, Janelle 1 Calonge, Ned 1 Harris, Russell 1; Affiliation: 1: U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 7/17/2007, Vol. 147 Issue 2, p123; Subject Term: MEDICAL policy; Subject Term: EVIDENCE-based medicine; Subject Term: DECISION making in clinical medicine; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyers, David S.
AU - Halvorson, Heather
AU - Luckhaupt, Sara
T1 - Screening for Chlamydial Infection: An Evidence Update for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/07/17/
VL - 147
IS - 2
M3 - Article
SP - 135
EP - W20
SN - 00034819
AB - Background: Chlamydial infection is the most common sexually transmitted bacterial infection in the United States, with an estimated 3 million new cases annually. In 2001, the U.S. Preventive Services Task Force (USPSTF) recommended that clinicians screen all sexually active women at increased risk for infection for Chlamydia trachomatis. Purpose: To summarize a systematic evidence review commissioned by the USPSTF in preparation for an update of its 2001 recommendation. Data Sources: English-language articles identified in PubMed between July 2000 and July 2005. Additional articles were identified by bibliographic reviews and discussions with experts. A total of 452 articles were identified. Study Selection: Explicit inclusion and exclusion criteria were used for each of 3 key questions. For studies of screening in nonpregnant women at increased risk, review was limited to randomized, controlled trials. For other groups, both randomized, controlled studies and nonrandomized, prospective, controlled studies were included. Data Abstraction: Using standardized forms, staff of the Agency for Healthcare Research and Quality abstracted data on study design, setting, sample, randomization, blinding, results, and harms. Data Synthesis: Only 1 new study met inclusion criteria. This poor-quality study of the effectiveness of screening for chlamydial infection among nonpregnant women at increased risk found that screening was associated with a lower prevalence of chlamydial infection and fewer reported cases of pelvic inflammatory disease at 1-year follow-up. Limitations: No new evidence was found on screening in pregnant women, nonpregnant women not at increased risk, or men. Conclusions: A systematic review found a small amount of new evidence to inform the USPSTF as it updates its recommendations regarding screening for chlamydial infection. There are large gaps in the evidence about screening men to improve health outcomes in women. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHLAMYDIA infections -- Diagnosis
KW - MEDICAL screening
KW - MEDICAL policy
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 25782589; Meyers, David S. 1 Halvorson, Heather 1 Luckhaupt, Sara 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 7/17/2007, Vol. 147 Issue 2, p135; Subject Term: CHLAMYDIA infections -- Diagnosis; Subject Term: MEDICAL screening; Subject Term: MEDICAL policy; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106153748
T1 - Academia and clinic. Current processes of the U.S. Preventive Services Task Force: refining evidence-based recommendation development.
AU - Guirguis-Blake J
AU - Calonge N
AU - Miller T
AU - Siu A
AU - Teutsch S
AU - Whitlock E
Y1 - 2007/07/17/
N1 - Accession Number: 106153748. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20070914. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Medical Practice, Evidence-Based -- Methods
KW - Policy Making -- Administration
KW - Practice Guidelines -- Standards
KW - Preventive Health Care -- Administration
KW - Communication
KW - Health Policy -- United States
KW - Preventive Health Care -- Methods
KW - United States
KW - United States Preventive Services Task Force
SP - 117
EP - 122
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 2
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - The U.S. Preventive Services Task Force (USPSTF), an independent panel that has provided the gold standard for evidence-based guidelines in prevention for the past 2 decades, continuously refines its methodology. To keep up with the evolving field of evidence- based medicine and to update recommendations in a timely, efficient, and transparent manner, the USPSTF has developed new methods for evidence reviews and recommendation development. This article summarizes the most recent changes in the recommendation development process, including how the USPSTF solicits and prioritizes topics for review, updates evidence reviews and recommendations, and communicates with its audience.
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 17576998.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106153749
T1 - Academia and clinic. How to read the new recommendation statement: methods update from the U.S. Preventive Services Task Force.
AU - Barton MB
AU - Miller T
AU - Wolff T
AU - Petitti D
AU - LeFevre M
AU - Sawaya G
AU - Yawn B
AU - Guirguis-Blake J
AU - Calonge N
AU - Harris R
Y1 - 2007/07/17/
N1 - Accession Number: 106153749. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20070914. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Medical Practice, Evidence-Based -- Methods
KW - Policy Making -- Administration
KW - Practice Guidelines -- Standards
KW - Preventive Health Care -- Administration
KW - Communication
KW - Health Policy
KW - Preventive Health Care -- Methods
KW - United States
KW - United States Preventive Services Task Force
SP - 123
EP - 127
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 2
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - Since 2001, the U.S. Preventive Services Task Force (USPSTF) has worked to refine its methods of evidence review and assessment and to create more usable documents in response to clinicians' needs. These changes have resulted in a revised grading system, as well as a new format and new language for the recommendation statement. This paper focuses on the changes to and the new look of the USPSTF recommendation statement. The new recommendation statement comprises 9 sections. Important changes include standardization of the format of the summary statement to specify what service is being recommended in what population; standardization of the headings in the rationale section; a change in the wording of the grade C recommendation and the I statement; and a new section, called 'Other Considerations,' in which salient issues related to cost-effectiveness, mandates, and other implementation issues are described.
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA.
U2 - PMID: 17576997.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106153749&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106153752
T1 - Clinical guidelines. Screening for chlamydial infection: an evidence update for the U.S. Preventive Services Task Force.
AU - Meyers DS
AU - Halvorson H
AU - Luckhaupt S
Y1 - 2007/07/17/
N1 - Accession Number: 106153752. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20070914. Revision Date: 20150711. Publication Type: Journal Article; CEU; consumer/patient teaching materials; practice guidelines; research; systematic review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Obstetric Care; Public Health. NLM UID: 0372351.
KW - Chlamydia Infections -- Prevention and Control
KW - Health Screening -- Standards
KW - Adolescence
KW - Chlamydia Infections -- Drug Therapy
KW - Chlamydia Infections -- Epidemiology
KW - Economic Aspects of Illness
KW - Education, Continuing (Credit)
KW - Female
KW - Health Services Needs and Demand
KW - Male
KW - Medical Practice, Evidence-Based
KW - Pregnancy
KW - Pregnancy Complications, Infectious -- Drug Therapy
KW - Pregnancy Complications, Infectious -- Epidemiology
KW - Pregnancy Complications, Infectious -- Prevention and Control
KW - Risk Factors
KW - Systematic Review
KW - United States
KW - Human
SP - 135
EP - I44
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 2
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Chlamydial infection is the most common sexually transmitted bacterial infection in the United States, with an estimated 3 million new cases annually. In 2001, the U.S. Preventive Services Task Force (USPSTF) recommended that clinicians screen all sexually active women at increased risk for infection for Chlamydia trachomatis. PURPOSE: To summarize a systematic evidence review commissioned by the USPSTF in preparation for an update of its 2001 recommendation. DATA SOURCES: English-language articles identified in PubMed between July 2000 and July 2005. Additional articles were identified by bibliographic reviews and discussions with experts. A total of 452 articles were identified. STUDY SELECTION: Explicit inclusion and exclusion criteria were used for each of 3 key questions. For studies of screening in nonpregnant women at increased risk, review was limited to randomized, controlled trials. For other groups, both randomized, controlled studies and nonrandomized, prospective, controlled studies were included. DATA ABSTRACTION: Using standardized forms, staff of the Agency for Healthcare Research and Quality abstracted data on study design, setting, sample, randomization, blinding, results, and harms. DATA SYNTHESIS: Only 1 new study met inclusion criteria. This poor-quality study of the effectiveness of screening for chlamydial infection among nonpregnant women at increased risk found that screening was associated with a lower prevalence of chlamydial infection and fewer reported cases of pelvic inflammatory disease at 1-year follow-up. LIMITATIONS: No new evidence was found on screening in pregnant women, nonpregnant women not at increased risk, or men. CONCLUSIONS: A systematic review found a small amount of new evidence to inform the USPSTF as it updates its recommendations regarding screening for chlamydial infection. There are large gaps in the evidence about screening men to improve health outcomes in women.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA.
U2 - PMID: 17576995.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106153752&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kavanaugh, Claudine J.
AU - Trumbo, Paula R.
AU - Ellwood, Kathleen C.
T1 - The U.S. Food and Drug Administration's Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2007/07/18/
VL - 99
IS - 14
M3 - Article
SP - 1074
EP - 1085
SN - 00278874
AB - Several studies have reported an inverse association between tomato and/or lycopene intake and the risk of some types of cancer. In 2004, the U.S. Food and Drug Administration (FDA) received two petitions for qualified health claims regarding tomatoes, lycopene, and the risk reduction for some forms of cancer. Health claims that characterize the relationship between a food or food component and a disease or health-related condition require premarket approval by FDA to be included on the labels of conventional foods and dietary supplements. Here we describe FDA's review of the scientific data for tomato and/or lycopene intake with respect to risk reduction for certain forms of cancer. The FDA found no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer. The FDA also found no credible evidence for an assocaition between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer. The FDA found very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMATIC reviews (Medical research)
KW - MEDICAL research
KW - TOMATOES
KW - LYCOPENE
KW - CANCER -- Risk factors
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 25996634; Kavanaugh, Claudine J. 1; Email Address: claudine.kavanaugh@fda.hhs.gov Trumbo, Paula R. 1 Ellwood, Kathleen C. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD; Source Info: 7/18/2007, Vol. 99 Issue 14, p1074; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: MEDICAL research; Subject Term: TOMATOES; Subject Term: LYCOPENE; Subject Term: CANCER -- Risk factors; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 12p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1093/jnci/djm031
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Kane, Robert
T1 - Re: When You Look Matters: The Effect of Assessment Schedule on Progression- Free Survival.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2007/07/18/
VL - 99
IS - 14
M3 - Letter
SP - 1131
EP - 1132
SN - 00278874
AB - A letter to the editor is presented in response to an article about the effect of assessment schedule on progression-free survival in cancer patients.
KW - LETTERS to the editor
KW - CANCER patients
N1 - Accession Number: 25996641; Kane, Robert 1; Email Address: robert.kane@fda.hhs.gov; Affiliation: 1: Division of Drug Oncology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Aye, Silver Spring, MD 20993-0002; Source Info: 7/18/2007, Vol. 99 Issue 14, p1131; Subject Term: LETTERS to the editor; Subject Term: CANCER patients; Number of Pages: 2p; Document Type: Letter
L3 - 10.1093/jnci/djm040
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25996641&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martella, Vito
AU - Bányai, Krisztián
AU - Lorusso, Eleonora
AU - Bellacicco, Anna Lucia
AU - Decaro, Nicola
AU - Camero, Michele
AU - Bozzo, Giancarlo
AU - Moschidou, Paschalina
AU - Arista, Serenella
AU - Pezzotti, Giovanni
AU - Lavazza, Antonio
AU - Buonavoglia, Canio
T1 - Prevalence of group C rotaviruses in weaning and post-weaning pigs with enteritis
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2007/07/20/
VL - 123
IS - 1-3
M3 - Article
SP - 26
EP - 33
SN - 03781135
AB - Abstract: Diarrheic fecal specimens collected from porcine herds were screened for the presence of group C rotaviruses using a reverse transcription-polymerase chain reaction (RT-PCR) assay. A total of 188 samples were tested and 54 were positive. When compiled these data with diagnostic results on group A rotaviruses and enteric caliciviruses we found that all but 5 group C rotavirus positive samples contained at least one additional virus. A subset of samples were subjected to nucleotide sequencing. The selected strains showed an unexpectedly wide range of nucleotide sequence heterogeneity (88.6–100%) to each other and to the reference porcine group C rotavirus strain, Cowden. The nucleotide sequence identity to the genuine bovine and human strains were, respectively, 86.8 and 87.2% or less. In conclusion, our study demonstrates that infection with group C rotavirus is frequent in Italian piggeries. The considerable rate of multiple infections requires further studies to investigate the pathogenic potential of group C rotaviruses in pigs, alone or in mixed infection, and raises challenges in the laboratory diagnosis of porcine enteric infections. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTESTINAL diseases
KW - CONSTIPATION
KW - DIARRHEA
KW - DIVERTICULOSIS
KW - Enteritis
KW - Group C rotavirus
KW - Pigs
KW - Zoonosis
N1 - Accession Number: 25411194; Martella, Vito 1; Email Address: v.martella@veterinaria.uniba.it Bányai, Krisztián 2 Lorusso, Eleonora 1 Bellacicco, Anna Lucia 1 Decaro, Nicola 1 Camero, Michele 1 Bozzo, Giancarlo 1 Moschidou, Paschalina 1 Arista, Serenella 3 Pezzotti, Giovanni 4 Lavazza, Antonio 5 Buonavoglia, Canio 1; Affiliation: 1: Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine of Bari, S.p. per Casamassima Km 3, 70010 Valenzano, Bari, Italy 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 3: Department of Hygiene and Microbiology, University of Palermo, Palermo, Italy 4: Istituto Zooprofilattico Sperimentale di Umbria/Marche, Perugia, Italy 5: Istituto Zooprofilattico Sperimentale di Lombardia/Emilia Romagna, Brescia, Italy; Source Info: Jul2007, Vol. 123 Issue 1-3, p26; Subject Term: INTESTINAL diseases; Subject Term: CONSTIPATION; Subject Term: DIARRHEA; Subject Term: DIVERTICULOSIS; Author-Supplied Keyword: Enteritis; Author-Supplied Keyword: Group C rotavirus; Author-Supplied Keyword: Pigs; Author-Supplied Keyword: Zoonosis; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vetmic.2007.03.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25411194&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, S.
AU - McDermott, P.F.
AU - White, D.G.
AU - Qaiyumi, S.
AU - Friedman, S.L.
AU - Abbott, J.W.
AU - Glenn, A.
AU - Ayers, S.L.
AU - Post, K.W.
AU - Fales, W.H.
AU - Wilson, R.B.
AU - Reggiardo, C.
AU - Walker, R.D.
T1 - Characterization of multidrug resistant Salmonella recovered from diseased animals
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2007/07/20/
VL - 123
IS - 1-3
M3 - Article
SP - 122
EP - 132
SN - 03781135
AB - Abstract: Three hundred and eighty Salmonella isolates recovered from animal diagnostic samples obtained from four state veterinary diagnostic laboratories (AZ, NC, MO, and TN) between 2002 and 2003 were tested for antimicrobial susceptibilities and further characterized for bla CMY beta-lactamase genes, class 1 integrons and genetic relatedness using PFGE. Forty-seven serovars were identified, the most common being S. Typhimurium (26%), S. Heidelberg (9%), S, Dublin (8%), S. Newport (8%), S. Derby (7%), and S. Choleraesuis (7%). Three hundred and thirteen (82%) isolates were resistant to at least one antimicrobial, and 265 (70%) to three or more antimicrobials. Resistance was most often observed to tetracycline (78%), followed by streptomycin (73%), sulfamethoxazole (68%), and ampicillin (54%), and to a lesser extent chloramphenicol (37%), kanamycin (37%), amoxicillin-clavulanic acid (20%), and ceftiofur (17%). With regards to animal of origin, swine Salmonella isolates displayed the highest rate of resistance, being resistant to at least one antimicrobial (92%), followed by those recovered from turkey (91%), cattle (77%), chicken (68%), and equine (20%). Serovars commonly showing multidrug resistance (MDR) to ≥9 antimicrobials were S. Uganda (100%), S. Agona (79%), and S. Newport (62%), compared to S. Heidelberg (11%) and S. Typhimurium (7%). Class-1 integrons were detected in 43% of all isolates, and were found to contain aadA, aadB, dhfr, cmlA and sat1 gene cassettes alone or in various combinations. All ceftiofur resistant isolates (n =66) carried the bla CMY beta-lactamase gene. A total of 230 PFGE patterns were generated among the 380 isolates tested using XbaI, indicating extensive genetic diversity across recovered Salmonella serovars, however, several MDR clones were repeatedly recovered from different diseased animals. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - LIVESTOCK
KW - ANTIBACTERIAL agents
KW - ANTI-infective agents
KW - Antimicrobial resistance
KW - Diseased animals
KW - Salmonella
N1 - Accession Number: 25411203; Zhao, S. 1; Email Address: shaohua.zhao@FDA.HHS.GOV McDermott, P.F. 1 White, D.G. 1 Qaiyumi, S. 1 Friedman, S.L. 1 Abbott, J.W. 1 Glenn, A. 1 Ayers, S.L. 1 Post, K.W. 2 Fales, W.H. 3 Wilson, R.B. 4 Reggiardo, C. 5 Walker, R.D. 1; Affiliation: 1: Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD 20708, United States 2: Rollins Animal Disease Diagnostic Laboratory, Raleigh, NC 27607, United States 3: University of Missouri, VMDL, Columbia, MO 65205, United States 4: CE Kord Animal Disease Diagnostic Laboratory, Tennessee Department of Agriculture, Nashville, TN 37204, United States 5: Arizona Veterinary Diagnostic Laboratory, University of Arizona, Tucson, AZ 85705, United States; Source Info: Jul2007, Vol. 123 Issue 1-3, p122; Subject Term: ENTEROBACTERIACEAE; Subject Term: LIVESTOCK; Subject Term: ANTIBACTERIAL agents; Subject Term: ANTI-infective agents; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Diseased animals; Author-Supplied Keyword: Salmonella; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vetmic.2007.03.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karbiwnyk, Christine M.
AU - Carr, Lori E.
AU - Turnipseed, Sherri B.
AU - Andersen, Wendy C.
AU - Miller, Keith E.
T1 - Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2007/07/23/
VL - 596
IS - 2
M3 - Article
SP - 257
EP - 263
SN - 00032670
AB - Abstract: The quinolones, oxolinic acid (OXO), flumequine (FLU), and nalidixic acid (NAL), are antibacterial drugs effective against Gram-negative bacteria. Quinolones are used in both human and veterinary medicine, but are currently not approved by the U.S. Food and Drug Administration for use in food fish. A liquid chromatography-fluorescence (LC-FL) method was developed to determine OXO, FLU, and NAL residues in shrimp. An additional liquid chromatography–mass spectrometry (LC–MS n ) method was created to confirm these residues using the same sample extract. Samples were prepared with a simple ethyl acetate extraction followed by solvent exchange into 0.2% formic acid and cleaned-up with hexane. Reverse phase chromatography was used to separate the three compounds in both procedures. For the LC-FL determinative method, fluorescence emission was monitored at 369nm with excitation at 327nm. With electrospray ionization, the three most abundant ions from the MS3 product ion spectrum were used to identify OXO, FLU, and NAL in the confirmation procedure. Shrimp samples fortified at levels ranging from 7.5 to 100ngg−1 were used to validate both methods. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUINOLONE antibacterial agents
KW - LIQUID chromatography
KW - FLUORESCENCE
KW - MASS spectrometry
KW - Confirmation
KW - Fluorescence
KW - Mass spectrometry
KW - Quinolones
KW - Residue analysis
KW - Shrimp
N1 - Accession Number: 25750391; Karbiwnyk, Christine M. 1; Email Address: christine.karbiwnyk@fda.hhs.gov Carr, Lori E. 2 Turnipseed, Sherri B. 1 Andersen, Wendy C. 1 Miller, Keith E. 3; Affiliation: 1: Animal Drugs Research Center, Food and Drug Administration, Denver, CO, United States 2: Denver District Laboratory, Food and Drug Administration, Denver, CO, United States 3: University of Denver, Denver, CO, United States; Source Info: Jul2007, Vol. 596 Issue 2, p257; Subject Term: QUINOLONE antibacterial agents; Subject Term: LIQUID chromatography; Subject Term: FLUORESCENCE; Subject Term: MASS spectrometry; Author-Supplied Keyword: Confirmation; Author-Supplied Keyword: Fluorescence; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Quinolones; Author-Supplied Keyword: Residue analysis; Author-Supplied Keyword: Shrimp; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.aca.2007.06.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25750391&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jon Brazier
AU - Leandro Pinto
AU - Ilana Balassiano
AU - Renata Boente
AU - Geraldo de Paula
AU - Eliane Ferreira
AU - Kátia Avelar
AU - Karla Miranda
AU - M. Ferreira
AU - Regina Domingues
T1 - New PCR ribotypes of Clostridium difficile detected in children in Brazil.
JO - Antonie van Leeuwenhoek
JF - Antonie van Leeuwenhoek
Y1 - 2007/07/26/
VL - 92
IS - 1
M3 - Article
SP - 53
EP - 59
SN - 00036072
AB - Abstract A total of 35 Brazilian isolates of Clostridium difficile from faecal stools and four isolates from hospital environments were analyzed by PCR ribotyping. A whole cell protein profile (as an alternative for serogrouping), in vitro toxin production and susceptibility to vancomycin, metronidazole and clindamycin were also investigated. All strains were typeable by both phenotypic and genotypic methods, and a total of 13 different PCR ribotypes were identified, of which seven (132, 133, 134, 135, 136, 142 and 143) were considered new types and accounted for 78.5% of all samples evaluated (including hospital environments). A non-toxigenic C. difficile PCR ribotype 133 was detected in all children groups examined (inpatients, outpatients and healthy children), whilst toxigenic PCR ribotypes 015, 131, 134 and 135 were associated mostly with symptomatic children. Serogroups G and D were disseminated both in patients from the community and from the pediatric hospital, with group G prevalent among outpatient children. All strains were susceptible to vancomycin and metronidazole but high levels of resistance to clindamycin were found, especially among serogroups G and D. Co-existence of different ribotypes and serogroups in the same individual was observed. The new seven ribotypes found in this investigation may represent strains characteristic of this region of Brazil. [ABSTRACT FROM AUTHOR]
AB - Copyright of Antonie van Leeuwenhoek is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Children -- Brazil
KW - Community life
KW - Clostridium difficile
KW - Brazil
N1 - Accession Number: 24890012; Jon Brazier 1; Leandro Pinto 2; Ilana Balassiano 3; Renata Boente 3; Geraldo de Paula 4; Eliane Ferreira 3; Kátia Avelar 5; Karla Miranda 3; M. Ferreira 3; Regina Domingues 3; Affiliations: 1: National Public Health Service Microbiology Cardiff University Hospital of Wales Anaerobe Reference Laboratory Cardiff UK Cardiff UK; 2: Universidade Federal de Juiz de Fora Juiz de Fora MG Brazil Juiz de Fora MG Brazil; 3: UFRJ Instituto de Microbiologia Prof. Paulo de Góes Rio de Janeiro RJ Brazil Rio de Janeiro RJ Brazil; 4: UFF Faculdade de Farmácia Niteroi RJ Brazil Niteroi RJ Brazil; 5: Instituto Oswaldo Cruz Fiocruz RJ Brazil Fiocruz RJ Brazil; Issue Info: Jul2007, Vol. 92 Issue 1, p53; Subject Term: Children -- Brazil; Subject Term: Community life; Subject Term: Clostridium difficile; Subject: Brazil; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mills, K.
AU - Ansah, T.A.
AU - Ali, S.F.
AU - Mukherjee, S.
AU - Shockley, D.C.
T1 - Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers
JO - Life Sciences
JF - Life Sciences
Y1 - 2007/07/26/
VL - 81
IS - 7
M3 - Article
SP - 600
EP - 608
SN - 00243205
AB - Abstract: Recent studies suggest that calcium influx via L-type calcium channels is necessary for psychostimulant-induced behavioral sensitization. In addition, chronic amphetamine upregulates subtype Cav1.2-containing L-type calcium channels. In the present studies, we assessed the effect of calcium channel blockers (CCBs) on cocaine-induced behavioral sensitization and determined whether the functional activity of L-type calcium channels is altered after repeated cocaine administration. Rats were administered daily intraperitoneal injections of either flunarizine (40 mg/kg), diltiazem (40 mg/kg) or cocaine (20 mg/kg) and the combination of the CCBs and cocaine for 30 days. Motor activities were monitored on Day 1, and every 6th day during the 30-day treatment period. Daily cocaine administration produced increased locomotor activity. Maximal augmentation of behavioral response to repeated cocaine administration was observed on Day 18. Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective. Measurement of tissue monoamine levels on Day 18 revealed cocaine-induced increases in DA and 5-HT in the nucleus accumbens. By contrast to behavioral response, diltiazem was more effective in attenuating increases in monoamine levels than flunarizine. Cocaine administration for 18 days produced increases in calcium uptake in synaptosomes prepared from the nucleus accumbens and frontal cortex. Increases in calcium uptake were abolished by flunarizine and diltiazem pretreatment. Taken together, the augmented cocaine-induced behavioral response on Day 18 may be due to increased calcium uptake in the nucleus accumbens leading to increased dopamine (DA) and serotonin (5-HT) release. Flunarizine and diltiazem attenuated the behavioral response by decreasing calcium uptake and decreasing neurochemical release. [Copyright &y& Elsevier]
AB - Copyright of Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALCIUM-binding proteins
KW - COCAINE
KW - CALCIUM antagonists
KW - TRANSFER factor (Immunology)
KW - Calcium channel blockers
KW - Cocaine
KW - Motor activity
KW - Rat
KW - Sensitization
KW - Synaptosomes
N1 - Accession Number: 26152343; Mills, K. 1 Ansah, T.A. 1; Email Address: tansah@mmc.edu Ali, S.F. 1,2 Mukherjee, S. 1 Shockley, D.C. 1; Affiliation: 1: Department of Pharmacology, Meharry Medical College, 1005 D.B. Todd Boulevard, Nashville, Tennessee 37208, USA 2: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Drive, Jefferson, Arkansas 72079-9502, USA; Source Info: Jul2007, Vol. 81 Issue 7, p600; Subject Term: CALCIUM-binding proteins; Subject Term: COCAINE; Subject Term: CALCIUM antagonists; Subject Term: TRANSFER factor (Immunology); Author-Supplied Keyword: Calcium channel blockers; Author-Supplied Keyword: Cocaine; Author-Supplied Keyword: Motor activity; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Sensitization; Author-Supplied Keyword: Synaptosomes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.lfs.2007.06.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seo, Sung-Chul
AU - Grinshpun, Sergey A.
AU - Iossifova, Yulia
AU - Schmechel, Detlef
AU - Rao, Carol Y.
AU - Reponen, Tiina
T1 - A New Field-Compatible Methodology for the Collection and Analysis of Fungal Fragments.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2007/08//
VL - 41
IS - 8
M3 - Article
SP - 794
EP - 803
SN - 02786826
AB - A field-compatible collection system was developed and tested for the collection and analysis of fungal fragments. The new collection system consists of two types of Sharp-Cut cyclone samplers (PM2.5 and PM1.0) and an after-filter. Fungal particles are collected into three size fractions: (1) spores (>2.5 μ m); (2) a fragment-spore mixture (1.0-2.5 μ m); and (3) submicrometer-sized fragments (<1.0 μ m). The system was laboratory-tested using polystyrene latex (PSL) particles and particulate matter aerosolized from sporulating Aspergillus versicolor and Stachybotrys chartarum cultures. In addition to the particle count measured with direct-reading instruments, the (1 → 3)-β-D-glucan content in each size fraction was determined with the Limulus Amebocyte Lysate (LAL) assay. Experiments conducted with PSL particles showed that the 50% cut-off values of the two cyclone samplers under the test conditions were 2.25 μ m and 1.05 μ m, respectively. No particle bounce onto the after-filter was observed when the total particle number entering the collection system was kept below 1.6 × 108. The (1 → 3)-β-D-glucan assay of samples aerosolized from both fungal species suggested that surface area is an important factor for determining the (1 → 3)-β-D-glucan content in the entire size-range of particles. In conclusion, the new methodology is a promising tool for separating and analyzing fungal fragment samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AEROSOLS (Sprays)
KW - EQUIPMENT & supplies
KW - FUNGAL cultures
KW - PARTICLE size determination
KW - EVALUATION
KW - ASPERGILLUS
KW - STACHYBOTRYS
KW - LIMULUS test
KW - GLUCANS
KW - FRAGMENTATION reactions
KW - SEPARATORS (Machines)
N1 - Accession Number: 25727964; Seo, Sung-Chul 1 Grinshpun, Sergey A. 1 Iossifova, Yulia 1 Schmechel, Detlef 2 Rao, Carol Y. 2 Reponen, Tiina 1; Affiliation: 1: Center for Health-Related Aerosol Studies, Department of Environmental Health, University of Cincinnati. Cincinnati, Ohio. USA 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Morgantown, West Virginia. USA; Source Info: Aug2007, Vol. 41 Issue 8, p794; Subject Term: AEROSOLS (Sprays); Subject Term: EQUIPMENT & supplies; Subject Term: FUNGAL cultures; Subject Term: PARTICLE size determination; Subject Term: EVALUATION; Subject Term: ASPERGILLUS; Subject Term: STACHYBOTRYS; Subject Term: LIMULUS test; Subject Term: GLUCANS; Subject Term: FRAGMENTATION reactions; Subject Term: SEPARATORS (Machines); Number of Pages: 10p; Illustrations: 1 Diagram, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1080/02786820701459940
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25727964&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waters, Thomas R.
T1 - WHEN IS IT SAFE TO MANUALLY LIFT A PATIENT?
JO - American Journal of Nursing
JF - American Journal of Nursing
Y1 - 2007/08//
VL - 107
IS - 8
M3 - Article
SP - 53
EP - 59
SN - 0002936X
AB - The article presents information on the initiative of the National Institute for Occupational Safety and Health (NIOSH) as it released the Revised NIOSH Lifting Equation. It is an ergonomics assessment tool that can be used to calculate the recommended weight limit for two-handed manual-lifting tasks. However, NIOSH excluded assessment of patient-handling tasks from the uses of the revised equation, arguing that such tasks involve too many variables.
KW - PATIENT positioning
KW - CARE of the sick
KW - CARE of people
KW - MEDICAL care
KW - HOME nursing
KW - OCCUPATIONAL health services
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 26130178; Waters, Thomas R. 1; Email Address: trw1@cdc.gov; Affiliation: 1: Research Safety Engineer, Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH; Source Info: Aug2007, Vol. 107 Issue 8, p53; Subject Term: PATIENT positioning; Subject Term: CARE of the sick; Subject Term: CARE of people; Subject Term: MEDICAL care; Subject Term: HOME nursing; Subject Term: OCCUPATIONAL health services; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 7p; Illustrations: 1 Cartoon or Caricature; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106154154
T1 - When is it safe to manually lift a patient?
AU - Waters TR
Y1 - 2007/08//
N1 - Accession Number: 106154154. Language: English. Entry Date: 20070914. Revision Date: 20150819. Publication Type: Journal Article; CEU; equations & formulas; exam questions; pictorial; review. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 0372646.
KW - Lifting -- Adverse Effects
KW - Lifting -- Standards
KW - Musculoskeletal Diseases -- Prevention and Control
KW - National Institute for Occupational Safety and Health -- Standards
KW - Occupational Hazards
KW - Occupational Safety -- Standards
KW - Occupational-Related Injuries -- Prevention and Control
KW - Weights and Measures
KW - Body Weight
KW - Education, Continuing (Credit)
KW - Ergonomics
KW - Female
KW - Lifting and Transfer Equipment
KW - Middle Age
KW - Occupational Safety -- Legislation and Jurisprudence -- United States
KW - United States
SP - 53
EP - 59
JO - American Journal of Nursing
JF - American Journal of Nursing
JA - AM J NURS
VL - 107
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - In 1994 the National Institute for Occupational Safety and Health (NIOSH) released the Revised NIOSH Lifting Equation-an ergonomics assessment tool that can be used to calculate the recommended weight limit for two-handed manual-lifting tasks. However, NIOSH excluded assessment of patient-handling tasks from the uses of the revised equation, arguing that such tasks involve too many variables. The equation in fact can be used to calculate a recommended weight limit for a limited range of patient-handling tasks in which the patient is cooperative and unlikely to move suddenly during the task. In general, the revised equation yields a recommended 35-lb. maximum weight limit for use in patient-handling tasks. When weight to be lifted exceeds this limit, assistive devices should be used.The Revised NIOSH Lifting Equation provides support for recommended weight limits.
SN - 0002-936X
AD - Research Safety Engineer, Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH.
U2 - PMID: 17667392.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brock, Tina Penick
AU - Smith, Scott R.
T1 - An Interdisciplinary Online Course in Health Care Informatics.
JO - American Journal of Pharmaceutical Education
JF - American Journal of Pharmaceutical Education
Y1 - 2007/08//
VL - 71
IS - 3
M3 - Article
SP - 1
EP - 5
SN - 00029459
AB - Objectives. To design an interdisciplinary course in health care informatics that enables students to: (1) understand how to incorporate technology into the provision of safe, effective and evidence-based health care; (2) make decisions about the value and ethical application of specific technologies; and (3) appreciate the perspectives and roles of patients and providers when using technology in care. Design. An online, interdisciplinary elective course using a distributive learning model was created. Standard courseware was used to manage teaching and to facilitate student/instructor interactions. Interactive, multimedia lectures were developed using Internet communication software. Assessment. Upon completion of the course, students demonstrated competency in identifying, analyzing, and applying informatics appropriately in diverse health settings. Conclusion. Online education using multimedia software technology is effective in teaching students about health informatics and providing an innovative opportunity for interdisciplinary learning. In light of the growing need for efficient health care informatics training, additional study of this methodology is warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Pharmaceutical Education is the property of American Association of Colleges of Pharmacy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSTRUCTIONAL systems design
KW - EVALUATION
KW - ONLINE courses
KW - INTERDISCIPLINARY approach in education
KW - WEB-based instruction -- Research
KW - EDUCATIONAL technology -- Research
KW - INTERNET in education
KW - PHARMACY -- Study & teaching
KW - Informatics
KW - interdisciplinary education
KW - internet
KW - online instruction
N1 - Accession Number: 26023388; Brock, Tina Penick 1,2; Email Address: tina.brock@pharmacy.ac.uk Smith, Scott R. 1,3; Affiliation: 1: University of North Carolina at Chapel Hill 2: University of London School of Pharmacy, United Kingdom 3: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Aug2007, Vol. 71 Issue 3, p1; Subject Term: INSTRUCTIONAL systems design; Subject Term: EVALUATION; Subject Term: ONLINE courses; Subject Term: INTERDISCIPLINARY approach in education; Subject Term: WEB-based instruction -- Research; Subject Term: EDUCATIONAL technology -- Research; Subject Term: INTERNET in education; Subject Term: PHARMACY -- Study & teaching; Author-Supplied Keyword: Informatics; Author-Supplied Keyword: interdisciplinary education; Author-Supplied Keyword: internet; Author-Supplied Keyword: online instruction; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Y.
AU - Xu, W.
AU - Shen, K.
AU - Xie, Z.
AU - Sun, L.
AU - Lu, Q.
AU - Liu, C.
AU - Liang, G.
AU - Beeler, J. A.
AU - Anderson, L. J.
T1 - Genetic variability of group A and B human respiratory syncytial viruses isolated from 3 provinces in China.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2007/08//
VL - 152
IS - 8
M3 - Article
SP - 1425
EP - 1434
SN - 03048608
AB - The genetic variability of HRSV in China was studied using nucleotide sequencing of the hypervariable C-terminal region of the G protein gene and phylogenetic analysis on 80 isolates obtained from three children’s hospitals over a period of three epidemic seasons, 1990/1991, 2000/2001, and 2003/2004. The results showed that 76/80 of these isolates belonged to group A and 4/80 belonged to group B. Phylogenetic analysis revealed that most of the group A isolates were genotype GA2 (74/76 isolates), and the other two isolates were GA3 and GA5. All group B isolates clustered into genotype GB3. There was substantial variation among the GA2 isolates, with nucleotide sequence and amino acid homologies ranging from 88.1–100% and 78.4–100%, respectively, in the hypervariable C-terminal region of the G protein gene. One group B virus, HRSV/Beijing/B/04/11, contained a 60-nucleotide duplication in the C-terminal region of the G protein, which was similar to what has been reported previously for isolates in several countries. This is the first report on the genetic diversity of human respiratory syncytial virus isolated during epidemic periods from children in China. These data provided a preliminary evaluation of patterns of circulation and the genetic diversity of isolates associated with HRSV epidemics within China. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN genetics -- Variation
KW - RESPIRATORY syncytial virus infections
KW - DIAGNOSIS
KW - NUCLEOTIDE sequence
KW - RESEARCH
KW - G proteins
KW - POLYMERASE chain reaction -- Diagnostic use
KW - CHINA
N1 - Accession Number: 25904848; Zhang, Y. 1 Xu, W. 1; Email Address: wenbo_xu1@yahoo.com.cn Shen, K. 2 Xie, Z. 2 Sun, L. 3 Lu, Q. 2 Liu, C. 2 Liang, G. 1 Beeler, J. A. 4 Anderson, L. J. 5; Affiliation: 1: China Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China 2: Beijing Children’s Hospital, Beijing, China 3: Changchun Children’s Hospital, Changchun, China 4: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA 5: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; Source Info: Aug2007, Vol. 152 Issue 8, p1425; Subject Term: HUMAN genetics -- Variation; Subject Term: RESPIRATORY syncytial virus infections; Subject Term: DIAGNOSIS; Subject Term: NUCLEOTIDE sequence; Subject Term: RESEARCH; Subject Term: G proteins; Subject Term: POLYMERASE chain reaction -- Diagnostic use; Subject Term: CHINA; Number of Pages: 10p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1007/s00705-007-0984-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ugolini, Donatella
AU - Puntoni, Riccardo
AU - Perera, Frederica P.
AU - Schulte, Paul A.
AU - Bonassi, Stefano
T1 - A bibliometric analysis of scientific production in cancer molecular epidemiology.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 2007/08//
VL - 28
IS - 8
M3 - Article
SP - 1774
EP - 1779
SN - 01433334
AB - Objectives: The main purpose of this research was to compare the scientific production in the field of cancer molecular epidemiology among countries and to evaluate the publication trend between 1995 and 2004. Methods: A bibliometric study was carried out searching the PubMed database with a combined search strategy based on the keywords listed in the medical subject headings and a free text search. Only articles from a representative subset of 92 journals—accounting for 80% of papers identified—were selected for the analysis, and the resulting 13 240 abstracts were manually checked according to a list of basic inclusion criteria. The study evaluated the number of publications and the impact factor (mean and sum), absolute and normalized by country population and gross domestic product. Results: A total of 3842 citations were finally selected for the analysis. Thirty-seven percent came from the European Union (UK, Germany, Italy, France and Sweden ranking at the top), 31.6% from USA and 9.7% from Japan. The highest mean impact factor was reported for Canada (6.3), USA (5.9), Finland (5.8) and UK (5.2). Finland, Sweden and Israel had the best ratio between scientific production and available resources. ‘Genetic polymorphism, glutathione transferase, breast neoplasm, risk factors, case–control studies and polymerase chain reaction’ were the most used keywords in each of the subgroups evaluated, although inclusion criteria may have privileged studies dealing with exogenous carcinogens. Conclusion: Cancer molecular epidemiology is an expanding area attracting an increasing interest. The identification of an operative definition is a necessary condition to give to this discipline a unique scientific identity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Carcinogenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER genetics
KW - MOLECULAR epidemiology
KW - MEDICAL literature
KW - MEDICAL publishing
KW - BIBLIOMETRICS
N1 - Accession Number: 44394713; Ugolini, Donatella 1,2; Email Address: donatella.ugolini@istge.it Puntoni, Riccardo 2 Perera, Frederica P. 3 Schulte, Paul A. 4 Bonassi, Stefano 5; Affiliation: 1: Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa 16132, Italy 2: Units of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa 16132, Italy 3: Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA 4: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA 5: Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa 16132, Italy; Source Info: Aug2007, Vol. 28 Issue 8, p1774; Subject Term: CANCER genetics; Subject Term: MOLECULAR epidemiology; Subject Term: MEDICAL literature; Subject Term: MEDICAL publishing; Subject Term: BIBLIOMETRICS; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1093/carcin/bgm129
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koturbashy, Igor
AU - Boykoy, Alex
AU - Rodriguez-Juarez, Rocio
AU - McDonald, Robert J.
AU - Tryndyak, Volodymyr P.
AU - Kovalchuk, Igor
AU - Pogribny, Igor P.
AU - Kovalchuk, Olga
T1 - Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo.
JO - Carcinogenesis
JF - Carcinogenesis
Y1 - 2007/08//
VL - 28
IS - 8
M3 - Article
SP - 1831
EP - 1838
SN - 01433334
AB - Radiation therapy is a primary treatment modality for brain tumors, yet it has been linked to the increased incidence of secondary, post-radiation therapy cancers. These cancers are thought to be linked to indirect radiation-induced bystander effect. Bystander effect occurs when irradiated cells communicate damage to nearby, non-irradiated ‘bystander’ cells, ultimately contributing to genome destabilization in the non-exposed cells. Recent evidence suggests that bystander effect may be epigenetic in nature; however, characterization of epigenetic mechanisms involved in bystander effect generation and its long-term persistence has yet to be defined. To investigate the possibility that localized X-ray irradiation induces persistent bystander effects in distant tissue, we monitored the induction of epigenetic changes (i.e. alterations in DNA methylation, histone methylation and microRNA (miRNA) expression) in the rat spleen tissue 24 h and 7 months after localized cranial exposure to 20 Gy of X-rays. We found that localized cranial radiation exposure led to the induction of bystander effect in lead-shielded, distant spleen tissue. Specifically, this exposure caused the profound epigenetic dysregulation in the bystander spleen tissue that manifested as a significant loss of global DNA methylation, alterations in methylation of long interspersed nucleotide element-1 (LINE-1) retrotransposable elements and down-regulation of DNA methyltransferases and methyl-binding protein methyl CpG binding protein 2 (MeCP2). Further, irradiation significantly altered expression of miR-194, a miRNA putatively targeting both DNA methyltransferase-3a and MeCP2. This study is the first to report conclusive evidence of the long-term persistence of bystander effects in radiation carcinogenesis target organ (spleen) upon localized distant exposure using the doses comparable with those used for clinical brain tumor treatments. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Carcinogenesis is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOTHERAPY
KW - BRAIN tumors
KW - CANCER cells
KW - IRRADIATION
KW - METHYLATION
N1 - Accession Number: 44394712; Koturbashy, Igor 1 Boykoy, Alex 1 Rodriguez-Juarez, Rocio 1 McDonald, Robert J. 2 Tryndyak, Volodymyr P. 3 Kovalchuk, Igor 1 Pogribny, Igor P. 3 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Alberta, T1K 3M4, Canada 2: Department of Neuroscience, University of Lethbridge, Alberta, T1K 3M4, Canada 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Aug2007, Vol. 28 Issue 8, p1831; Subject Term: RADIOTHERAPY; Subject Term: BRAIN tumors; Subject Term: CANCER cells; Subject Term: IRRADIATION; Subject Term: METHYLATION; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 8p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1093/carcin/bgm053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gopee, Neera V.
AU - Howard, Paul C.
T1 - A time course study demonstrating RNA stability in postmortem skin
JO - Experimental & Molecular Pathology
JF - Experimental & Molecular Pathology
Y1 - 2007/08//
VL - 83
IS - 1
M3 - Article
SP - 4
EP - 10
SN - 00144800
AB - Abstract: Knowledge of the factors regulating the rate of mRNA degradation, including postmortem delay, is important in determining the reliability of gene expression patterns in dermal tissue. Since RNA stability can be tissue dependent, this study evaluates the effect of postmortem interval on the integrity of total RNA or the levels of representative mRNA species in murine cutaneous tissue. Pieces of fresh skin tissue were excised for periods of 0–60 min from SKH-1 female hairless mice that were maintained at room temperature post-sacrifice. Total RNA was subsequently isolated and RNA integrity from each specimen was evaluated. Bioanalyzer profiles showed no apparent change in 28S/18S rRNA ratio or RNA integrity number at time points up to 60 min. Changes in mRNA expression levels of five selected genes were determined by real-time quantitative PCR. There were no statistical differences in the relative gene expressions of Ccnd1, Hif1α, cMyc and Cyr61 as a function of postmortem interval. Our data suggest that the molecular quality of cutaneous tissue is well preserved for at least 60 min after death, which can be regarded as important information for consideration of the order for tissue procurement in in vivo studies and acute ex vivo dermal studies. [Copyright &y& Elsevier]
AB - Copyright of Experimental & Molecular Pathology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - MESSENGER RNA
KW - RNA
KW - NUCLEIC acids
KW - 28S/18S ribosomal RNA
KW - Postmortem
KW - qRT-PCR
KW - RNA integrity
KW - Skin
N1 - Accession Number: 25255493; Gopee, Neera V. 1 Howard, Paul C.; Email Address: Paul.Howard@fda.hhs.gov; Affiliation: 1: Division of Biochemical Toxicology, and National Toxicology Program Center for Phototoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Department of Health and Human Services, 3900 NCTR Road, HFT-110, Jefferson, Arkansas 72079, USA; Source Info: Aug2007, Vol. 83 Issue 1, p4; Subject Term: GENE expression; Subject Term: MESSENGER RNA; Subject Term: RNA; Subject Term: NUCLEIC acids; Author-Supplied Keyword: 28S/18S ribosomal RNA; Author-Supplied Keyword: Postmortem; Author-Supplied Keyword: qRT-PCR; Author-Supplied Keyword: RNA integrity; Author-Supplied Keyword: Skin; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.yexmp.2006.11.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolffe, M.
AU - Landry, R. J.
AU - Alpar, J. J.
T1 - Identification of the source of permanent glare from a three-piece IOL.
JO - Eye
JF - Eye
Y1 - 2007/08//
VL - 21
IS - 8
M3 - Article
SP - 1078
EP - 1082
PB - Nature Publishing Group
SN - 0950222X
AB - ObjectiveTo identify the source of unwanted glare images from a three-piece intraocular lens (IOL) implant following cataract surgery.MethodThe IOL and posterior capsule were examined under mydriatic and nonmydriatic conditions using direct focal illumination from a slit lamp biomicroscope. Direct focal illumination was undertaken with both a narrow beam (0.1 mm in width) and small spot (0.1 mm in diameter) to identify the points at which the glare images were stimulated. While observing the location of the beam with the slit lamp biomicroscope, the patient indicated when the glare images were stimulated.ResultsThe nasal haptic insertion into the optic was identified as the source of temporal line images arising from lights such as headlamps from oncoming cars and street lamps. The adjacent edge of the IOL was also identified as the likely source of additional cob web-like light rays.ConclusionsThe haptic insertions in three-piece IOLs may, under certain conditions, interfere with light entering the pupil and produce extraneous images. Large mesopic pupils and decentred IOLs are conditions that increase the likelihood of unwanted glare images.Eye (2007) 21, 1078–1082; doi:10.1038/sj.eye.6702539; published online 25 August 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Eye is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLARE
KW - INTRAOCULAR lenses
KW - ARTIFICIAL implants
KW - CATARACT surgery
KW - LIGHTING
KW - BEAM optics
KW - diffuse glare image
KW - haptic-glare
KW - line glare image
KW - three-piece intraocular lenses
N1 - Accession Number: 26147702; Wolffe, M. 1 Landry, R. J. 2; Email Address: robert.landry@fda.hhs.gov Alpar, J. J. 3; Affiliation: 1: Moseley, Birmingham, UK 2: Division of Physics, Center for Devices and Radiological Health, FDA, Rockville, MD, USA 3: St Luke Eye Institute, Amarillo, TX, USA; Source Info: Aug2007, Vol. 21 Issue 8, p1078; Subject Term: GLARE; Subject Term: INTRAOCULAR lenses; Subject Term: ARTIFICIAL implants; Subject Term: CATARACT surgery; Subject Term: LIGHTING; Subject Term: BEAM optics; Author-Supplied Keyword: diffuse glare image; Author-Supplied Keyword: haptic-glare; Author-Supplied Keyword: line glare image; Author-Supplied Keyword: three-piece intraocular lenses; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 335129 Other Lighting Equipment Manufacturing; Number of Pages: 5p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1038/sj.eye.6702539
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Landry, R. J.
AU - Ilev, I. K.
AU - Pfefer, T. J.
AU - Wolffe, M.
AU - Alpar, J. J.
T1 - Characterizing reflections from intraocular lens implants.
JO - Eye
JF - Eye
Y1 - 2007/08//
VL - 21
IS - 8
M3 - Article
SP - 1083
EP - 1086
PB - Nature Publishing Group
SN - 0950222X
AB - ObjectiveTo develop a test method for characterizing glare from intraocular lenses (IOLs) and to confirm a clinical finding that the haptic insertion in the optic of a three-piece IOL produces extraneous line images.MethodThe method consists of directing a collimated Gaussian laser beam to various parts of the IOL to be tested in a water-filled model eye. Reflected images produced in the retinal plane are photographed with a digital camera.ResultsA test method was developed to characterize the source of glare images from IOLs. The test method developed was used to confirm a clinical finding that the haptic insertion in the optic of a three-piece IOL produces extraneous line images.ConclusionsThe method developed can be used to characterize and pin point the source of extraneous glare images from intraocular lens implants. The haptic insertion in the optic of a three-piece IOL has been identified as a source of line images.Eye (2007) 21, 1083–1086; doi:10.1038/sj.eye.6702540; published online 25 August 2006 [ABSTRACT FROM AUTHOR]
AB - Copyright of Eye is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTRAOCULAR lenses
KW - OPHTHALMIC lenses
KW - LASER beams
KW - ARTIFICIAL implants
KW - GLARE
KW - OPTOMETRY
KW - IOL diffuse glare image
KW - IOL glare test method
KW - IOL haptic glare
KW - IOL Line glare image
N1 - Accession Number: 26147701; Landry, R. J. 1; Email Address: robert.landry@fda.hhs.gov Ilev, I. K. 1 Pfefer, T. J. 1 Wolffe, M. 2 Alpar, J. J. 3; Affiliation: 1: Division of Physics, Center for Devices and Radiological Health, FDA, Rockville, MD, USA 2: Scientific Consultant, Moseley, Birmingham, UK 3: St Luke Eye Institute, Amarillo, TX, USA; Source Info: Aug2007, Vol. 21 Issue 8, p1083; Subject Term: INTRAOCULAR lenses; Subject Term: OPHTHALMIC lenses; Subject Term: LASER beams; Subject Term: ARTIFICIAL implants; Subject Term: GLARE; Subject Term: OPTOMETRY; Author-Supplied Keyword: IOL diffuse glare image; Author-Supplied Keyword: IOL glare test method; Author-Supplied Keyword: IOL haptic glare; Author-Supplied Keyword: IOL Line glare image; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 327215 Glass Product Manufacturing Made of Purchased Glass; Number of Pages: 4p; Illustrations: 4 Color Photographs, 1 Diagram; Document Type: Article
L3 - 10.1038/sj.eye.6702540
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Sung-Kug
AU - Kim, Cheong Tae
AU - Lee, Joo-Won
AU - Jhee, Ok Hwa
AU - Om, Ae Seon
AU - Kang, Ju Seop
AU - Moon, Tae Wha
T1 - Analysis of ethyl carbamate in Korean soy sauce using high-performance liquid chromatography with fluorescence detection or tandem mass spectrometry and gas chromatography with mass spectrometry
JO - Food Control
JF - Food Control
Y1 - 2007/08//
VL - 18
IS - 8
M3 - Article
SP - 975
EP - 982
SN - 09567135
AB - Abstract: A specific, sensitive procedure involving high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) was developed and compared to other analytical methods for quantification of ethyl carbamate (EC) in Korean soy sauce products. HPLC with a fluorescence detector was not applicable for monitoring trace amounts of EC in soy sauce due to its low detection limit (20ppb). The use of gas chromatography (GC) coupled to MS could be applied to soy sauce, but it was not as simple and fast as HPLC/MS/MS. The GC/MS procedure exhibited excellent linearity over the concentration range of 10–200ppb with a 0.5ppb limit of detection (LOD) and 82.7±3.1% recovery. A procedure involving HPLC/MS/MS with multiple reaction monitoring was developed. The characteristic transitions of m/z 90→62 for EC as well as m/z 104→62 for propyl carbamate (PC) as the internal standard were monitored. Good linearity was obtained both in the range from 10 to 100ppb and in the range from 0.1 to 20ppb with a LOD of 0.05ppb. The average recovery was 92.2±1.7%. The applicability of the GC/MS and developed HPLC/MS/MS methods was demonstrated by detection of EC in 12 kinds of commercial Korean soy sauce products at levels of 0.5 and 0.1ppb, respectively. The new HPLC/MS/MS method provided greater sensitivity with a simpler and shorter confirmatory analysis than the GC/MS method. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URETHANE
KW - SOY sauce
KW - HIGH performance liquid chromatography
KW - MASS spectrometry
KW - Ethyl carbamate
KW - HPLC/MS/MS
KW - Korean soy sauce
N1 - Accession Number: 23866186; Park, Sung-Kug 1 Kim, Cheong Tae 2 Lee, Joo-Won 3 Jhee, Ok Hwa 3,4 Om, Ae Seon 4 Kang, Ju Seop 3 Moon, Tae Wha 2; Email Address: twmoon@snu.ac.kr; Affiliation: 1: Center for Food Standard Evaluation, Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-gu, Seoul 122-704, Republic of Korea 2: School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-921, Republic of Korea 3: Department of Pharmacology, College of Medicine, Hanyang University, 17 Heangdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea 4: Department of Food and Nutrition, College of Human Ecology and Institute of Biomedical Science, Hanyang University, 17 Heangdang-dong, Sungdong-gu, Seoul 133-791, Republic of Korea; Source Info: Aug2007, Vol. 18 Issue 8, p975; Subject Term: URETHANE; Subject Term: SOY sauce; Subject Term: HIGH performance liquid chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Ethyl carbamate; Author-Supplied Keyword: HPLC/MS/MS; Author-Supplied Keyword: Korean soy sauce; NAICS/Industry Codes: 311941 Mayonnaise, Dressing, and Other Prepared Sauce Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.foodcont.2006.05.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khan, Ashraf A.
AU - Melvin, Cathy D.
AU - Dagdag, Elsie B.
T1 - Identification and molecular characterization of Salmonella spp. from unpasteurized orange juices and identification of new serotype Salmonella strain S. enterica serovar Tempe
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2007/08//
VL - 24
IS - 5
M3 - Article
SP - 539
EP - 543
SN - 07400020
AB - Abstract: Several Salmonella enterica serotypes were isolated from unpasteurized orange juice samples analysed as a follow-up to an outbreak in 1999 of S. enterica serotype Muenchen in the Pacific Northwest regions of United States. Eleven S. enterica strains were serotyped and identified as S. enterica serotype Muenchen (2), S. enterica serotype Hidalgo (2), S. enterica serotype Alamo (1), S. enterica serotype Gaminera (2), S. enterica serotype Javiana (2) and a new serotyped strain S. enterica serotype Tempe (2). The identity of the new serotype S. enterica serovar Tempe serotype 30:b:1,7:z33 was confirmed by the National Salmonella Reference Laboratory at NCID/CDC, Atlanta. These strains were sensitive to ampicillin, chloramphenicol, kanamycin, tetracycline, streptomycin and sulfisoxazole antibiotics. Isolates were screened for invasion (invA) and virulence (spvC) genes using specific primers for these two genes by polymerase chain reaction. All strains were positive for invA gene giving 321-bp fragment, however negative to virulence spvC gene. For pulsed-field gel electrophoresis (PFGE) analysis, Salmonella strain plugs were made and digested with XbaI and subjected to 18-h electrophoresis. The PFGE patterns were different for each S. enterica serotypes suggesting the several origins of contamination in outbreak. S. enterica serotype. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - SALMONELLA
KW - ELECTROPHORESIS
KW - CITRUS fruits
KW - Orange juice
KW - Pulsed-field gel electrophoresis
KW - Salmonella enterica serovar Muenchen
KW - Salmonella enterica serovar Tempe
KW - Polymerase Chain Reaction
N1 - Accession Number: 24381369; Khan, Ashraf A. 1; Email Address: Ashraf.khan@fda.hhs.gov Melvin, Cathy D. 2 Dagdag, Elsie B. 3; Affiliation: 1: Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA 2: Arkansas Regional Laboratory, ORA, US FDA, Jefferson, Arkansas 72079, USA 3: Pacific Regional Laboratory—Southwest, US FDA, Los Angeles, California, USA; Source Info: Aug2007, Vol. 24 Issue 5, p539; Subject Term: ENTEROBACTERIACEAE; Subject Term: SALMONELLA; Subject Term: ELECTROPHORESIS; Subject Term: CITRUS fruits; Author-Supplied Keyword: Orange juice; Author-Supplied Keyword: Pulsed-field gel electrophoresis; Author-Supplied Keyword: Salmonella enterica serovar Muenchen; Author-Supplied Keyword: Salmonella enterica serovar Tempe; Author-Supplied Keyword: Polymerase Chain Reaction; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 111320 Citrus (except Orange) Groves; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.fm.2006.09.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, J. L.
AU - Spitz, H. B.
AU - Yiin, J. H.
T1 - ESTIMATING ACTIVE BONE MARROW DOSE FROM OCCUPATIONAL EXPOSURE TO URANIUM AT A FORMER GASEOUS DIFFUSION PLANT.
JO - Health Physics
JF - Health Physics
Y1 - 2007/08//
VL - 93
IS - 2
M3 - Article
SP - 113
EP - 119
SN - 00179078
AB - This article discusses the estimation of active bone marrow radiation dose from occupational exposure to uranium at a former gaseous diffusion plant in Oak Ridge, Tennessee. Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for more than 500 subjects exposed between 1945 and 1985 as part of a nested study of multiple myeloma. According to the authors, the data suggests that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. They concluded that exposures were very low compared to dose from naturally occurring radionuclides in non-occupationally exposed persons and especially occupationally exposed.
KW - Uranium enrichment
KW - Industrial hygiene
KW - Uranium compounds -- Environmental aspects
KW - Gaseous diffusion plants -- Safety measures
KW - Urinalysis
KW - Bone marrow
KW - Multiple myeloma
KW - Uranium industry -- Environmental aspects
KW - Dose-response relationship (Radiation)
KW - Tennessee
KW - bone marrow
KW - dose
KW - exposure
KW - occupational
KW - uranium
KW - Oak Ridge National Laboratory
N1 - Accession Number: 25852237; Anderson, J. L.; Email Address: JLAnderson@cdc.gov; Spitz, H. B.; Yiin, J. H. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226; Issue Info: Aug2007, Vol. 93 Issue 2, p113; Thesaurus Term: Uranium enrichment; Thesaurus Term: Industrial hygiene; Subject Term: Uranium compounds -- Environmental aspects; Subject Term: Gaseous diffusion plants -- Safety measures; Subject Term: Urinalysis; Subject Term: Bone marrow; Subject Term: Multiple myeloma; Subject Term: Uranium industry -- Environmental aspects; Subject Term: Dose-response relationship (Radiation); Subject: Tennessee; Author-Supplied Keyword: bone marrow; Author-Supplied Keyword: dose; Author-Supplied Keyword: exposure; Author-Supplied Keyword: occupational; Author-Supplied Keyword: uranium ; Company/Entity: Oak Ridge National Laboratory; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stewart, Kate A.
AU - Neumann, Peter J.
AU - Fletcher, Suzanne W.
AU - Barton, Mary B.
T1 - The Effect of Immediate Reading of Screening Mammograms on Medical Care Utilization and Costs after False-Positive Mammograms.
JO - Health Services Research
JF - Health Services Research
Y1 - 2007/08//
VL - 42
IS - 4
M3 - Article
SP - 1464
EP - 1482
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To investigate whether decreased anxiety associated with immediate reading of screening mammograms resulted in lower downstream utilization and costs among women with false-positive mammograms. Data Sources/Study Setting. We identified 1,140 women,≥age 40, with false-positive mammograms and 12-month follow-up after participating in a trial of immediate versus batch mammographic reading between February 1999 and January 2001 in a multispecialty group managed care practice in Massachusetts. Study Design. We determined downstream utilization and costs for study participants by immediate and batch reading status. Data Collection/Extraction Methods. Demographic, comorbidity, and medical care utilization data were obtained from survey data and computerized medical record databases. Costs included direct medical costs, patient time, travel and copayments, and additional professional time costs associated with immediate reading. Principal Findings. Immediate reading cost an additional $4.40 per screening mammogram. Women with immediate readings had more follow-up mammograms (781 versus 750, p=.018) and fewer diagnostic ultrasounds (176 versus 219, p=.016) than women with batch readings. Costs to the health plan for breast care were approximately 10 percent higher for immediate readings in multivariable analyses ( p=.046), but no significant difference was seen in total societal costs ( p=.072). Conclusions. Immediate mammogram reading was associated with increased costs to the health plan and changes in follow-up radiology procedures. These costs must be examined alongside beneficial effects of immediate reading. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMOGRAMS
KW - BREAST exams
KW - MEDICAL care use
KW - MEDICAL care costs
KW - WOMEN patients
KW - MASSACHUSETTS
KW - controlled trial
KW - costs
KW - immediate reading
KW - Mammography
KW - utilization
N1 - Accession Number: 25558932; Stewart, Kate A. 1 Neumann, Peter J. 2,3 Fletcher, Suzanne W. 4 Barton, Mary B. 5; Affiliation: 1: Department of Health Care Policy, 180 Longwood Avenue, Boston, MA 02115 2: Tufts University School of Medicine 3: Director, Center for the Evaluation of Value and Risk in Health, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, MA 4: Department of Ambulatory Care and Prevention, Boston, MA 5: Scientific Director, U.S. Preventive Services Task Force, Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD; Source Info: Aug2007, Vol. 42 Issue 4, p1464; Subject Term: MAMMOGRAMS; Subject Term: BREAST exams; Subject Term: MEDICAL care use; Subject Term: MEDICAL care costs; Subject Term: WOMEN patients; Subject Term: MASSACHUSETTS; Author-Supplied Keyword: controlled trial; Author-Supplied Keyword: costs; Author-Supplied Keyword: immediate reading; Author-Supplied Keyword: Mammography; Author-Supplied Keyword: utilization; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 19p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2006.00660.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DeBellas, Carmen
AU - Solimando, Dominic A.
AU - Waddell, J. Aubrey
T1 - Cisplatin, Doxorubicin, and High-dose Methotrexate for Osteosarcoma.
JO - Hospital Pharmacy
JF - Hospital Pharmacy
Y1 - 2007/08//
VL - 42
IS - 8
M3 - Article
SP - 702
EP - 711
SN - 00185787
AB - The increasing complexity of cancer chemotherapy increases the requirement that pharmacists be familiar with these highly toxic agents. This column will review various issues related to preparation, dispensing, and administration of cancer chemotherapy, and review various agents, both commercially available and investigational, used to treat malignant diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hospital Pharmacy is the property of Thomas Land Publishers Incorporated and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CISPLATIN
KW - DOXORUBICIN
KW - METHOTREXATE
KW - OSTEOSARCOMA
KW - CHEMOTHERAPY (Cancer)
N1 - Accession Number: 26292874; DeBellas, Carmen 1 Solimando, Dominic A. 2; Email Address: OncRxSvc@aol.com; Waddell, J. Aubrey 3,4; Email Address: waddfour@charter.net; Affiliation: 1: Pharmacist/project manager, Division of Anti- Infective and Ophthalmology Products, Center for Drug Evaluation and Research, Food and Drug Administration 2: President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203 3: Professor, University of Tennessee College of Pharmacy 4: Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804; Source Info: Aug2007, Vol. 42 Issue 8, p702; Subject Term: CISPLATIN; Subject Term: DOXORUBICIN; Subject Term: METHOTREXATE; Subject Term: OSTEOSARCOMA; Subject Term: CHEMOTHERAPY (Cancer); Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bonaventura, Celia
AU - Henkens, Robert
AU - Alayash, Abdu I.
AU - Crumbliss, Alvin L.
T1 - Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins.
JO - IUBMB Life
JF - IUBMB Life
Y1 - 2007/08//
VL - 59
IS - 8/9
M3 - Article
SP - 498
EP - 505
PB - Wiley-Blackwell
SN - 15216543
AB - A review of the oxidative and nitrosative reactions of cell-free hemoglobin-based oxygen carriers (HBOCs) shows that these reactions are intimately linked and are subject to allosteric control. Cross-linking reactions used to produce HBOCs introduce conformational constraints and result in Hbs with reduced responses to heterotropic and homotropic allosteric effectors. The Nernst plots of heme oxidation of cross-linked HBOCs are shifted to higher potentials relative to unmodified Hb in the absence of allosteric effectors, in accord with their T-state stabilization and right-shifted Hill plots of O2 binding. They exhibit enhanced rates of autoxidation and nitrite-induced oxidation, features that appear due to their having more solvent-accessible heme pockets. The stability of their NO-Hb derivatives varies as a result of allosteric effects on the extent of formation of pentacoordinate NO-heme geometry by α chains and subsequent oxidation of partner β chains. The physiological implications of these findings on the safety, efficacy and design of second generation HBOCs are discussed in the framework of a reaction scheme showing linkages between Hb-mediated redox reactions. These redox reactions can drive formation of SNO-Hb and other reactive species and are of significance for the use of cell-free Hbs in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of IUBMB Life is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLOSTERIC proteins
KW - HEMOGLOBIN
KW - OXIDATION-reduction reaction
KW - CHEMISTRY
KW - BLOOD substitutes
KW - OXYGEN carriers
KW - NITRIC oxide
KW - NITRITES
KW - allostery
KW - blood substitutes
KW - HBOCs
KW - Hemoglobin
KW - nitric oxide
KW - nitrite
KW - redox chemistry
N1 - Accession Number: 26205528; Bonaventura, Celia 1; Email Address: bona@duke.edu Henkens, Robert 1 Alayash, Abdu I. 2 Crumbliss, Alvin L. 3; Affiliation: 1: Nicholas School of the Environment and Earth Sciences, Duke University Marine Laboratory, Beaufort, North Carolina, USA 2: Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA 3: Department of Chemistry, Duke University, Durham, North Carolina, USA; Source Info: Aug2007, Vol. 59 Issue 8/9, p498; Subject Term: ALLOSTERIC proteins; Subject Term: HEMOGLOBIN; Subject Term: OXIDATION-reduction reaction; Subject Term: CHEMISTRY; Subject Term: BLOOD substitutes; Subject Term: OXYGEN carriers; Subject Term: NITRIC oxide; Subject Term: NITRITES; Author-Supplied Keyword: allostery; Author-Supplied Keyword: blood substitutes; Author-Supplied Keyword: HBOCs; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: nitric oxide; Author-Supplied Keyword: nitrite; Author-Supplied Keyword: redox chemistry; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1080/15216540601188546
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klabunde, Carrie N.
AU - Lanier, David
AU - Breslau, Erica S.
AU - Zapka, Jane G.
AU - Fletcher, Robert H.
AU - Ransohoff, David F.
AU - Winawer, Sidney J.
T1 - Improving Colorectal Cancer Screening in Primary Care Practice: Innovative Strategies and Future Directions.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2007/08//
VL - 22
IS - 8
M3 - Article
SP - 1195
EP - 1205
SN - 08848734
AB - Colorectal cancer (CRC) screening has been supported by strong research evidence and recommended in clinical practice guidelines for more than a decade. Yet screening rates in the United States remain low, especially relative to other preventable diseases such as breast and cervical cancer. To understand the reasons, the National Cancer Institute and Agency for Healthcare Research and Quality sponsored a review of CRC screening implementation in primary care and a program of research funded by these organizations. The evidence base for improving CRC screening supports the value of a New Model of Primary Care Delivery: 1. a team approach, in which responsibility for screening tasks is shared among other members of the practice, would help address physicians' lack of time for preventive care; 2. information systems can identify eligible patients and remind them when screening is due; 3. involving patients in decisions about their own care may enhance screening participation; 4. monitoring practice performance, supported by information systems, can help target patients at increased risk because of family history or social disadvantage; 5. reimbursement for services outside the traditional provider-patient encounter, such as telephone and e-mail contacts, may foster enhanced screening delivery; 6. training opportunities in communication, cultural competence, and use of information technologies would improve provider competence in core elements of screening programs. Improvement in CRC screening rates largely depends on the efforts of primary care practices to implement effective systems and procedures for screening delivery. Active engagement and support of practices are essential for the enormous potential of CRC screening to be realized. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON cancer
KW - CANCER patients
KW - CLINICAL medicine
KW - PRIMARY care (Medicine)
KW - UNITED States
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 26237867; Klabunde, Carrie N. 1; Email Address: klabunde@mail.nih.gov Lanier, David 2 Breslau, Erica S. 3 Zapka, Jane G. 4 Fletcher, Robert H. 5 Ransohoff, David F. 6 Winawer, Sidney J. 7; Affiliation: 1: Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Boulevard, Bethesda, MD 20892-734.4, USA 2: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD, USA 3: Applied Cancer Screening Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA 4: Biostotistics, Bioinformotics and Epidemiology, Medical University of South Carolina, Charleston, SC, USA 5: Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA 6: School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 7: Department of Medicine, Memorial Sloan-Keffering Cancer Center, New York, NY, USA; Source Info: Aug2007, Vol. 22 Issue 8, p1195; Subject Term: COLON cancer; Subject Term: CANCER patients; Subject Term: CLINICAL medicine; Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s11606-007-0231-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mansfield, Neil J.
AU - Maeda, Setsuo
T1 - The apparent mass of the seated human exposed to single-axis and multi-axis whole-body vibration
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2007/08//
VL - 40
IS - 11
M3 - Article
SP - 2543
EP - 2551
SN - 00219290
AB - Abstract: Most workplaces where workers are exposed to whole-body vibration involves simultaneous motion in the fore-and-aft (x-), lateral (y-) and vertical (z-) directions. Previous studies reporting the biomechanical response of people exposed to vibration have almost always used single-axis vibration stimuli. This paper reports a study where apparent masses of 15 subjects were measured whilst exposed to single-axis and tri-axial whole-body vibration. Each subject was exposed to 28 vibration conditions comprising every combination of single-axis and tri-axial vibration with magnitudes of 0.4 and 0.8ms−2 r.m.s. in each direction, once with backrest contact and once without backrest contact. Results show that increasing the magnitude of vibration in directions orthogonal to that being measured affects the apparent mass, causing a reduction in the resonance frequency as the total magnitude of vibration increases. It is demonstrated that the apparent mass resonance frequency is a function of the total vibration magnitude in all axes rather than a function of the vibration magnitude in the direction being measured. It is also shown that, for individuals, the frequency of the peak in the apparent mass in one direction is not related to the frequency of the peak in another direction. It is concluded that more complex biomechanical models are required in order to simulate human response to multi-axis vibration. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK environment
KW - VIBRATION (Mechanics) -- Physiological effect
KW - MECHANICAL impedance
KW - HUMAN mechanics
KW - PHYSIOLOGICAL aspects
KW - Apparent mass
KW - Mechanical impedance
KW - Multi-axis vibration
KW - Whole-body vibration
N1 - Accession Number: 25944448; Mansfield, Neil J. 1; Email Address: n.j.mansfield@lboro.ac.uk Maeda, Setsuo 2; Email Address: maedas@h.jniosh.go.jp; Affiliation: 1: Department of Human Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK 2: Hazard Evaluation and Epidemiology Research Group, Japan National Institute of Occupational Safety and Health, Nagao 6-21-1, Tama-Ku, Kawasaki 214-8585, Japan; Source Info: Aug2007, Vol. 40 Issue 11, p2543; Subject Term: WORK environment; Subject Term: VIBRATION (Mechanics) -- Physiological effect; Subject Term: MECHANICAL impedance; Subject Term: HUMAN mechanics; Subject Term: PHYSIOLOGICAL aspects; Author-Supplied Keyword: Apparent mass; Author-Supplied Keyword: Mechanical impedance; Author-Supplied Keyword: Multi-axis vibration; Author-Supplied Keyword: Whole-body vibration; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jbiomech.2006.10.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - C. B’Hymer
T1 - Development of a Gas Chromatographic Test for the Quantitation of the Biomarker 2-Butoxyacetic Acid in Urine Samples.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 2007/08//
VL - 45
IS - 7
M3 - Article
SP - 422
EP - 427
SN - 00219665
AB - An accurate and precise method is developed and evaluated for the detection and quantitation of 2-butoxyacetic acid (2-BAA), a metabolite and biomarker for human exposure to 2-butoxyethanol. The solvent 2-butoxyethanol (2-BE) is extensively used in various industrial and domestic applications, and it is a health concern owing to its toxicity. Sample preparation consists of liquid–liquid extraction (LLE) of urine, then esterification of 2-BAA to produce the ethyl ester analog. The gas chromatographic conditions utilize a dimethyl polysiloxane phase (HP-1) capillary column and a mass spectrometer (MS) for detection of the analyte. Validation of this method includes a recovery study using fortified urine samples, which demonstrated good accuracy and precision; recovery varied between 100% and 102% of theory, with relative standard deviations of replicate samples at 2.8% and less. The detection limit of this method ranges from 0.005 to 0.015 µg/mL equivalent level of 2-BAA in urine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINE
KW - BUTOXYETHANOL
KW - BIOCHEMICAL markers
KW - GAS chromatography
N1 - Accession Number: 26269843; C. B’Hymer 1; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, OH 45226; Source Info: Aug2007, Vol. 45 Issue 7, p422; Subject Term: URINE; Subject Term: BUTOXYETHANOL; Subject Term: BIOCHEMICAL markers; Subject Term: GAS chromatography; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hinchey, Joseph
AU - Sunhee Lee
AU - Bo Y. Jeon
AU - Basaraba, Randall J.
AU - Venkataswamy, Manjunatha M.
AU - Bing Chen
AU - John Chan
AU - Braunstein, Miriam
AU - Orme, Ian M.
AU - Derrick, Steven C.
AU - Morris, Sheldon L.
AU - Jacobs Jr., William R.
AU - Porcelli, Steven A.
AU - Lee, Sunhee
AU - Jeon, Bo Y
AU - Chen, Bing
AU - Chan, John
AU - Jacobs, William R Jr
T1 - Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2007/08//
VL - 117
IS - 8
M3 - journal article
SP - 2279
EP - 2288
SN - 00219738
AB - The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulence-associated protein secretion system, enhanced the apoptosis of infected macrophages by diminishing secretion of mycobacterial superoxide dismutase. Deletion of secA2 markedly increased priming of antigen-specific CD8(+) T cells in vivo, and vaccination of mice and guinea pigs with a secA2 mutant significantly increased resistance to M. tuberculosis challenge compared with standard M. bovis bacille Calmette-Guérin vaccination. Our results define a mechanism for a key immune evasion strategy of M. tuberculosis and provide what we believe to be a novel approach for improving mycobacterial vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS -- Prevention
KW - ADENOSINE triphosphatase
KW - ANIMAL experimentation
KW - BACTERIAL proteins
KW - BACTERIAL vaccines
KW - CELL lines
KW - COMPARATIVE studies
KW - GUINEA pigs
KW - MACROPHAGES
KW - RESEARCH -- Methodology
KW - MEDICAL cooperation
KW - MICE
KW - MUTATION (Biology)
KW - MYCOBACTERIUM
KW - MYCOBACTERIUM tuberculosis
KW - RESEARCH
KW - SUPEROXIDE dismutase
KW - TUBERCULOSIS
KW - EVALUATION -- Research
KW - MEMBRANE transport proteins
N1 - Accession Number: 110575803; Hinchey, Joseph 1 Sunhee Lee 1,2 Bo Y. Jeon 3 Basaraba, Randall J. 4 Venkataswamy, Manjunatha M. 1 Bing Chen 1,2 John Chan 1,5 Braunstein, Miriam 6 Orme, Ian M. 4 Derrick, Steven C. 3 Morris, Sheldon L. 3 Jacobs Jr., William R. 1,2; Email Address: jacobs@aecom.yu.edu Porcelli, Steven A. 1,5 Lee, Sunhee Jeon, Bo Y Chen, Bing Chan, John Jacobs, William R Jr; Affiliation: 1: Department of Microbiology and Immunology. 2: Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, New York, USA. 3: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA. 4: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA. 5: Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA. 6: Department of Microbiology, University of North Carolina, Chapel Hill, North Carolina, USA.; Source Info: Aug2007, Vol. 117 Issue 8, p2279; Subject Term: TUBERCULOSIS -- Prevention; Subject Term: ADENOSINE triphosphatase; Subject Term: ANIMAL experimentation; Subject Term: BACTERIAL proteins; Subject Term: BACTERIAL vaccines; Subject Term: CELL lines; Subject Term: COMPARATIVE studies; Subject Term: GUINEA pigs; Subject Term: MACROPHAGES; Subject Term: RESEARCH -- Methodology; Subject Term: MEDICAL cooperation; Subject Term: MICE; Subject Term: MUTATION (Biology); Subject Term: MYCOBACTERIUM; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: RESEARCH; Subject Term: SUPEROXIDE dismutase; Subject Term: TUBERCULOSIS; Subject Term: EVALUATION -- Research; Subject Term: MEMBRANE transport proteins; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 5 Graphs; Document Type: journal article
L3 - 10.1172/JCI31947
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ohsawa, A.
T1 - Efficient charge neutralization with an ac corona ionizer
JO - Journal of Electrostatics
JF - Journal of Electrostatics
Y1 - 2007/08//
VL - 65
IS - 9
M3 - Article
SP - 598
EP - 606
SN - 03043886
AB - Abstract: This paper discusses the problem of obtaining effective charge neutralization by an ac corona ionizer with airflow. The motion of ions and the neutralization of a charged object for different discharge frequencies and airflow velocities are investigated by a computer fluid model for positive and negative ions. The results of the investigation show that, in the region of ion transport, the quasi-neutralized charge distribution self-generated by positive and negative ions during charge neutralization can effectively transport the ions themselves from an ionizer to a charged object and significantly reduce both the unwanted fluctuation and dc offset in the potential of the object at a steady state, resulting in efficient and precise charge neutralization. Since the quasi-neutralization greatly depends on the relationship between the discharge frequency and airflow velocity, the control of the relationship may lead to better neutralization with an air-blowing ac ionizer. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electrostatics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUTRALIZATION (Chemistry)
KW - CHARGE transfer
KW - QUASIANALYTIC functions
KW - CORONA (Electricity)
KW - Ac ionizer
KW - Airflow
KW - Charge neutralization
KW - Discharge frequency
N1 - Accession Number: 25107512; Ohsawa, A. 1; Email Address: ohsawa@s.jniosh.go.jp; Affiliation: 1: Electrical Safety Research Group, National Institute of Occupational Safety and Health, 1-4-6 Umezono, Kiyose, Tokyo 204-0024, Japan; Source Info: Aug2007, Vol. 65 Issue 9, p598; Subject Term: NEUTRALIZATION (Chemistry); Subject Term: CHARGE transfer; Subject Term: QUASIANALYTIC functions; Subject Term: CORONA (Electricity); Author-Supplied Keyword: Ac ionizer; Author-Supplied Keyword: Airflow; Author-Supplied Keyword: Charge neutralization; Author-Supplied Keyword: Discharge frequency; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.elstat.2007.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mahabir, Somdat
AU - Abnet, Christian C.
AU - You-Lin Qiao
AU - Ratnasinghe, Luke D.
AU - Dawsey, Sanford M.
AU - Zhi-Wei Dong
AU - Taylor, Philip R.
AU - Mark, Steven D.
T1 - A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2007/08//
VL - 61
IS - 8
M3 - Article
SP - 737
EP - 741
SN - 0143005X
AB - Background: Stroke is the leading cause of death in Linxian, China. Although there is evidence of DNA damage in experimental stroke, no data exist on DNA repair and stroke in human populations. Aim: To assess the risk of stroke conferred by polymorphisms in the DNA repair genes, XRCC1, XPD23 and APE/ref-i in a cohort of individuals originally assembled as subjects in two cancer prevention trials in Linxian, China. Methods: The subjects for this prospective study were sampled from a cohort of 4005 eligible subjects who were alive and cancer free in 1991 and had blood samples available for DNA extraction. Using real-time Taqman analyses, all incident cases of stroke (n = 118) that developed from May 1996, and an age- and a sex-stratified random sample (n = 454) drawn from all eligible subjects were genotyped. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% CIs. Results: No association was observed between polymorphisms in APE/ref-1 codon 148 and XRCC1 ∗6 codon 194, and stroke. Polymorphisms in XRCC1 ∗10 codon 399 were associated with a significantly reduced risk of stroke (RR 0.59, 95% Cl 0.36 to 0.96, p = 0.033), whereas XPD23 codon 312 was associated with a significantly increased risk of stroke (RR 2.18, 95% Cl 1.14 to 4.17, p = 0.010). Conclusions: Polymorphisms in DNA repair genes may be important in the aetiology of stroke. These data should stimulate research on DNA damage and repair in stroke. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Epidemiology & Community Health is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMORPHISM (Zoology)
KW - DNA repair
KW - CEREBROVASCULAR disease
KW - DNA damage
KW - CANCER prevention
KW - CHINA
N1 - Accession Number: 26032006; Mahabir, Somdat 1; Email Address: smahabir@mdanderson.org Abnet, Christian C. 2 You-Lin Qiao 3 Ratnasinghe, Luke D. 4 Dawsey, Sanford M. 2 Zhi-Wei Dong 3 Taylor, Philip R. 5 Mark, Steven D. 6; Affiliation: 1: Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA 3: Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China 4: Center for Structural Genomics, NCTR, Food and Drug Administration, Jefferson and Arkansas Cancer Research Center, UAMS, Little Rock, Arkansas, USA 5: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA 6: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA; Source Info: Aug2007, Vol. 61 Issue 8, p737; Subject Term: POLYMORPHISM (Zoology); Subject Term: DNA repair; Subject Term: CEREBROVASCULAR disease; Subject Term: DNA damage; Subject Term: CANCER prevention; Subject Term: CHINA; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.11 36/jech.2006.048934
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ulirsch, Gregory V.
AU - Ball, Louise M.
AU - Kaye, Wendy
AU - Shy, Carl M.
AU - Lee, Carolyn V.
AU - Crawford-Brown, Douglas
AU - Symons, Michael
AU - Holloway, Tracey
T1 - Effect of particulate matter air pollution on hospital admissions and medical visits for lung and heart disease in two southeast Idaho cities.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2007/08//
VL - 17
IS - 5
M3 - Article
SP - 478
EP - 487
PB - Nature Publishing Group
SN - 15590631
AB - Few, if any, published time series studies have evaluated the effects of particulate matter air exposures by combining hospital admissions with medical visit data for smaller populations. We investigated the relationship between daily particulate matter (<10 μm in aerometric diameter or PM10) exposures with admissions and medical visits (emergency room, urgent care, and family practice) for respiratory and cardiovascular disease in Pocatello and Chubbuck, Idaho (population about 60,000), from November 1994 through March 2000. Within generalized linear models, time, weather, influenza, and day-of-week effects were controlled. In single-pollutant models, respiratory disease admissions and visits increased (7.1–15.4% per 50 μg/m3 PM10) for each age group analyzed, with the highest increases in two groups, children and especially the elderly. Statistical analyses suggest that the results probably did not occur by chance. Sensitivity analyses did not provide strong evidence that the respiratory disease effect estimates were sensitive to reasonable changes in the final degrees of freedom choice for time and weather effects. No strong evidence of confounding by NO2 and SO2 was found from results of multi-pollutant models. Ozone and carbon monoxide data were not available to include multi-pollutant models, but evidence suggests that they were not a problem. Unexpectedly, evidence of an association between PM10 with cardiovascular disease was not found, possibly due to the lifestyles of the mostly Mormon study population. Successful time series analyses can be performed on smaller populations if diverse, centralized databases are available. Hospitals that offer urgent or other primary care services may be a rich source of data for researchers. Using data that potentially represented a wide-range of disease severity, the findings provide evidence that evaluating only hospital admissions or emergency room visit effects may underestimate the overall morbidity due to acute particulate matter exposures. Further work is planned to test this conclusion.Journal of Exposure Science and Environmental Epidemiology (2007) 17, 478–487; doi:10.1038/sj.jes.7500542; published online 14 February 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICULATE matter
KW - LUNG diseases
KW - CHILDREN -- Health
KW - LENGTH of stay in hospitals
KW - CARBON monoxide
KW - AIR pollution
KW - child exposure/health
KW - particulate matter
KW - population-based studies
KW - pulmonary disease
N1 - Accession Number: 26147638; Ulirsch, Gregory V. 1; Email Address: gulirsch@cdc.gov Ball, Louise M. 2 Kaye, Wendy 3 Shy, Carl M. 4 Lee, Carolyn V. 3 Crawford-Brown, Douglas 2 Symons, Michael 5 Holloway, Tracey 6; Affiliation: 1: Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, GA, USA 2: Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC, USA 3: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, GA, USA 4: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA 5: Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC, USA 6: Nelson Institute for Environmental Studies, University of Wisconsin, Madison, WI, USA; Source Info: Aug2007, Vol. 17 Issue 5, p478; Subject Term: PARTICULATE matter; Subject Term: LUNG diseases; Subject Term: CHILDREN -- Health; Subject Term: LENGTH of stay in hospitals; Subject Term: CARBON monoxide; Subject Term: AIR pollution; Author-Supplied Keyword: child exposure/health; Author-Supplied Keyword: particulate matter; Author-Supplied Keyword: population-based studies; Author-Supplied Keyword: pulmonary disease; Number of Pages: 10p; Illustrations: 6 Charts, 1 Map; Document Type: Article
L3 - 10.1038/sj.jes.7500542
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Canada, Robin E.
AU - Turner, Barbara J.
T1 - Talking to patients about screening colonoscopy -- where conversations fall short.
JO - Journal of Family Practice
JF - Journal of Family Practice
Y1 - 2007/08//
VL - 56
IS - 8
M3 - Article
SP - 649
EP - 649
PB - Frontline Medical Communications
SN - 00943509
AB - The article presents an investigation about screening colonoscopy in the U.S. The methods include recruiting 30 primary care physicians and physicians-in-training from four practices to counsel a patient. An assessment was also made each for the key informational points, positive or negative message framing, type of numeracy information and use of colloquial or technical language. Most physicians discussed the benefits of colorectal cancer screening, its status as a standard exploratory procedure and the use of sedation. Although, most physician used positive simple terms to describe colonoscopy, they often omitted key information.
KW - COLONOSCOPY
KW - COLON (Anatomy) -- Examination
KW - CANCER patients
KW - MEDICAL care
KW - ENDOSCOPY
KW - MEDICAL records
KW - MEDICAL screening
KW - HEALTH risk assessment
KW - UNITED States
N1 - Accession Number: 26344293; Canada, Robin E. 1,2 Turner, Barbara J. 3; Email Address: bturner@mail.medupenn.edu; Affiliation: 1: Internal Medicine Residency Program of the Hospital of the University of Pennsylvania, Primary Care Program, Whiteriver, Arizona 2: Medical Staff, Whiteriver Indian Health Service, Whiteriver, Arizona 3: Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia; Source Info: Aug2007, Vol. 56 Issue 8, p649; Subject Term: COLONOSCOPY; Subject Term: COLON (Anatomy) -- Examination; Subject Term: CANCER patients; Subject Term: MEDICAL care; Subject Term: ENDOSCOPY; Subject Term: MEDICAL records; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meldrum, Richard J.
AU - Wilson, Ian G.
T1 - Salmonella and Campylobacter in United Kingdom Retail Raw Chicken in 2005.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/08//
VL - 70
IS - 8
M3 - Article
SP - 1937
EP - 1939
SN - 0362028X
AB - The United Kingdom Food Standards Agency commissioned a survey of Salmonella and Campylobacter in raw, whole chickens at retail in Wales and Northern Ireland between March and December 2005 to measure the baseline prevalence rates of these two significant pathogens. In total, 877 retail samples were examined for Campylobacter and Salmonella by enrichment methods. Overall contamination rates of 70.2% for Campylobacter and 4.0% for Salmonella were found. There was a statistically significant difference in Campylobacter rates between fresh and frozen samples, with fresh samples having a higher rate. There was no statistically significant difference between samples taken from retailers and butchers. Campylobacter was significantly more common in Northern Ireland than in Wales. Salmonella was significantly more common in Wales. The findings indicate the need for further investigation to explore why measures that have been successful in reducing Salmonella in the United Kingdom in recent years have failed to contribute to the control of Campylobacter. Identifying the factors responsible could lead to the introduction of more effective controls throughout the industry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Campylobacter
KW - Foodborne diseases
KW - Food poisoning
KW - Great Britain
N1 - Accession Number: 26112127; Meldrum, Richard J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Wilson, Ian G. 2; Affiliations: 1: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, UK; 2: Northern Ireland Public Health Laboratory, Bacteriology Department, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AD, UK; Issue Info: Aug2007, Vol. 70 Issue 8, p1937; Thesaurus Term: Salmonella; Thesaurus Term: Campylobacter; Thesaurus Term: Foodborne diseases; Thesaurus Term: Food poisoning; Subject: Great Britain; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Meldrum, R. J.
AU - Smith, R. M. M.
T1 - Occurrence of Listeria monocytogenes in Sandwiches Available to Hospital Patients in Wales, United Kingdom.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/08//
VL - 70
IS - 8
M3 - Article
SP - 1958
EP - 1960
SN - 0362028X
AB - A survey for the presence of Listeria monocytogenes in hospital sandwiches was carried out in Wales, United Kingdom, between October 2005 and March 2006. The main aim of the survey was to establish the baseline rate of L. monocytogenes in hospital sandwiches after an outbreak of listeriosis among hospital patients in 2004 was epidemiologically linked to the consumption of contaminated sandwiches. The overall positive rate found in hospital sandwiches was 2.84% for enriched culture and 0.21% for direct counts. The unsatisfactory rate (>100 CFU/g) for hospital sandwiches was 0.1%. The conclusion was that hospital sandwiches generally presented a low hazard to consumers. In addition to establishing the overall baseline and the unsatisfactory rates in hospital sandwiches in Wales for this period, the study compared the rates found in hospital sandwiches with the rates found in sandwiches simultaneously sampled from general retailers. The aim of this part of the study was to compare the relative rates associated with hospital and retail sandwiches to ascertain if there were any differences in the positive rate. The conclusion of this part of the survey was that there was not a statistically significant difference in rates between sandwiches sampled from hospitals and those sampled from general retailers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Foodborne diseases
KW - Listeria monocytogenes
KW - Hospital patients
KW - Great Britain
N1 - Accession Number: 26112131; Meldrum, R. J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; Smith, R. M. M. 2; Affiliations: 1: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK; 2: Communicable Disease Surveillance Centre Wales, Abton House, Wedal Road, Cardiff CF4 3QX, UK; Issue Info: Aug2007, Vol. 70 Issue 8, p1958; Thesaurus Term: Bacterial diseases; Thesaurus Term: Foodborne diseases; Subject Term: Listeria monocytogenes; Subject Term: Hospital patients; Subject: Great Britain; Number of Pages: 3p; Document Type: Article
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DB - eih
ER -
TY - JOUR
AU - Moss, William J.
AU - Scott, Susana
AU - Mugala, Nanthalile
AU - Ndhlovu, Zaza
AU - Beeler, Judy A.
AU - Audet, Susette A.
AU - Ngala, Mirriam
AU - Mwangala, Sheila
AU - Nkonga-Mwangilwa, Chansa
AU - Ryon, Judith J.
AU - Monze, Mwaka
AU - Kasolo, Francis
AU - Quinn, Thomas C.
AU - Cousens, Simon
AU - Griffin, Diane E.
AU - Cutts, Felicity T.
T1 - Immunogenicity of Standard-Titer Measles Vaccine in HIV-1-Infected and Uninfected Zambian Children: An Observational Study.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/08//8/1/2007
VL - 196
IS - 3
M3 - Article
SP - 347
EP - 355
SN - 00221899
AB - Background. Achieving the level of population immunity required for measles elimination may be difficult in regions of high human immunodeficiency virus type 1 (HIV-1) prevalence, because HIV-1-infected children may be less likely to respond to or maintain protective antibody levels after vaccination. Methods. We conducted a prospective study of the immunogenicity of standard-titer measles vaccine administered at 9 months of age to HIV-1-infected and uninfected children in Lusaka, Zambia. Results. From May 2000 to November 2002, 696 children aged 2–8 months were enrolled. Within 6 months of vaccination, 88% of 50 HIV-1-infected children developed antibody levels of ⩾120 mIU/mL, compared with 94% of 98 HIV-seronegative children and 94% of 211 HIV-seropositive but uninfected children (P=.3). By 27 months after vaccination, however, only half of the 18 HIV-1-infected children who survived and returned for follow-up maintained measles antibody levels ⩾120 mIU/mL, compared with 89% of 71 uninfected children (P=.001) and in contrast with 92% of 12 HIV-1-infected children revaccinated during a supplemental measles immunization activity. Conclusions. Although HIV-1-infected children showed good primary antibody responses to measles vaccine, their rapid waning of antibody suggests that measles vaccination campaigns may need to be repeated more frequently in areas of high HIV-1 prevalence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN immunogenetics
KW - MEASLES vaccine
KW - INFECTION in children
KW - HIV-positive persons
KW - VIRAL vaccines
KW - MEASLES -- Vaccination
KW - IMMUNOGENETICS
KW - IMMUNIZATION
N1 - Accession Number: 25883198; Moss, William J. 1,2; Email Address: wmoss@jhsph.edu Scott, Susana 3 Mugala, Nanthalile 4 Ndhlovu, Zaza 2 Beeler, Judy A. 5 Audet, Susette A. 5 Ngala, Mirriam 4 Mwangala, Sheila 4 Nkonga-Mwangilwa, Chansa 4 Ryon, Judith J. 2 Monze, Mwaka 4 Kasolo, Francis 4 Quinn, Thomas C. 6 Cousens, Simon 3 Griffin, Diane E. 2 Cutts, Felicity T. 3; Affiliation: 1: Department of Epidemiology, Rockville, Maryland 2: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Rockville, Maryland 3: London School of Hygiene and Tropical Medicine, London, United Kingdom 4: Virology Laboratory, University Teaching Hospital, Lusaka, Zambia 5: Food and Drug Administration, Rockville, Maryland 6: Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, National Institutes of Health, Bethesda, Rockville, Maryland; Source Info: 8/1/2007, Vol. 196 Issue 3, p347; Subject Term: HUMAN immunogenetics; Subject Term: MEASLES vaccine; Subject Term: INFECTION in children; Subject Term: HIV-positive persons; Subject Term: VIRAL vaccines; Subject Term: MEASLES -- Vaccination; Subject Term: IMMUNOGENETICS; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1086/519169
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105826371
T1 - The relationship between spirituality and depressive symptoms: testing psychosocial mechanisms.
AU - Mofidi M
AU - DeVellis RF
AU - DeVellis BM
AU - Blazer DG
AU - Panter AT
AU - Jordan JM
Y1 - 2007/08//
N1 - Accession Number: 105826371. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 0375402.
KW - Depression -- Epidemiology
KW - Spirituality
KW - Attitude
KW - Depression -- Diagnosis
KW - Depression -- Psychosocial Factors
KW - Female
KW - Health Care Delivery
KW - Health Status
KW - Male
KW - Middle Age
KW - Models, Psychological
KW - North Carolina
KW - Prevalence
KW - Psychological Tests
KW - Rural Population
KW - Support, Psychosocial
KW - Surveys
KW - Volunteer Workers -- Psychosocial Factors
KW - Human
SP - 681
EP - 688
JO - Journal of Nervous & Mental Disease
JF - Journal of Nervous & Mental Disease
JA - J NERV MENT DIS
VL - 195
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Although many studies suggest lower rates of depressive symptoms in those who report greater spirituality, few have investigated the mechanisms by which spirituality might relate to depressive symptoms. The current study aimed to elucidate potential psychosocial mechanisms that link these 2 variables. Data were drawn from a community-dwelling stratified sample of 630 racially diverse adults in rural North Carolina. Spirituality was assessed by 6 items of the Daily Spiritual Experiences Scale. Depressive symptoms were measured using 4 subscales from the Center for Epidemiological Studies-Depression. Hypothesized mediators were optimism, volunteering, and perceived social support. Structural equation modeling was used to test whether proposed mediators explain a link between spirituality and depressive symptoms. The model demonstrated a satisfactory fit. Spirituality was indirectly related to depressive symptoms. More specifically, spirituality was significantly associated with optimism and volunteering but not with social support, and optimism, volunteering and perceived social support were significantly associated with depressive symptoms. The link between spirituality and depressive symptoms is indirect. The relationship is mediated by optimism, volunteering, and social support. Findings present research and practice implications.
SN - 0022-3018
AD - US Department of Health and Human Services, Health Resources and Services Administration, Rockville, Maryland
U2 - PMID: 17700301.
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DB - rzh
ER -
TY - JOUR
AU - Gao, Pengfei
AU - King, William P.
AU - Shaffer, Ronald
T1 - Review of Chamber Design Requirements for Testing of Personal Protective Clothing Ensembles.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/08//
VL - 4
IS - 8
M3 - Article
SP - 562
EP - 571
PB - Taylor & Francis Ltd
SN - 15459624
AB - This review focuses on the physical requirements for conducting ensemble testing and describes the salient issues that organizations involved in the design, test, or certification of personal protective equipment (PPE) and protective clothing ensembles need to consider for strategic planning. Several current and proposed PPE ensemble test practices and standards were identified. The man-in-simulant test (MIST) is the primary procedure used by the military to evaluate clothing ensembles for protection against chemical and biological warfare agents. MIST has been incorporated into the current editions of protective clothing and equipment standards promulgated by the National Fire Protection Association (NFPA). ASTM has recently developed a new test method (ASTM F 2588-06) for MIST evaluation of protective ensembles. Other relevant test methods include those described in International Organization for Standardization (ISO) standards. The primary differences among the test methods were the choice of test challenge material (e.g., sulfur hexafluoride, methyl salicylate, sodium chloride particles, corn oil, fluorophore-impregnated silica) and the exercise protocol for the subject(s). Although ensemble test methods and standards provide detailed descriptions of the test procedures, none give specific requirements for chamber design. A literature survey identified 28 whole-body exposure chambers that have been or could potentially be used for testing protective clothing ensembles using human test subjects. Median chamber size, median floor space, and median volume per subject were calculated from 15 chambers (involving human test subjects), where size information is available. Based on the literature survey of existing chambers and the review of the current and proposed standards and test methods, chamber design requirements will be dictated by the test methods selected. Due to widely different test conditions for aerosol/particulate and vapor ensemble testing, it is unlikely that a single chamber could accommodate all types of ensemble testing. With increasing use of the MIST protocol by NFPA for CBRN certification of structural firefighting gear and protective ensembles for first responders, the need for MIST laboratory capability is clear. However, existing chambers can likely be adapted to accommodate MIST with some modifications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Protective clothing
KW - Aerosols (Sprays)
KW - Sulfur hexafluoride
KW - Salt
KW - Silica
KW - aerosol exposure
KW - chamber design requirement
KW - chemical vapor exposure
KW - human exposure chamber
KW - man-in-simulant test (MIST)
KW - protective clothing ensemble
N1 - Accession Number: 75127784; Gao, Pengfei 1; King, William P. 2; Shaffer, Ronald 1; Affiliations: 1: National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health. Pittsburgh, Pennsylvania; 2: EG&G Technical Services, Inc.. Pittsburgh, Pennsylvania; Issue Info: Aug2007, Vol. 4 Issue 8, p562; Thesaurus Term: Protective clothing; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Sulfur hexafluoride; Subject Term: Salt; Subject Term: Silica; Author-Supplied Keyword: aerosol exposure; Author-Supplied Keyword: chamber design requirement; Author-Supplied Keyword: chemical vapor exposure; Author-Supplied Keyword: human exposure chamber; Author-Supplied Keyword: man-in-simulant test (MIST); Author-Supplied Keyword: protective clothing ensemble; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/15459620701448416
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Glaser, Robert
AU - Kurimo, Robert
AU - Shulman, Stanley
T1 - Performance Testing of NIOSH Method 5524/ASTM Method D-7049-04, for Determination of Metalworking Fluids.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/08//
VL - 4
IS - 8
M3 - Article
SP - 583
EP - 595
PB - Taylor & Francis Ltd
SN - 15459624
AB - A performance test of NIOSH Method 5524/ASTM Method D-7049-04 for analysis of metalworking fluids (MWF) was conducted. These methods involve determination of the total and extractable weights of MWF samples; extractions are performed using a ternary blend of toluene:dichloromethane:methanol and a binary blend of methanol:water. Six laboratories participated in this study. A preliminary analysis of 20 blank samples was made to familiarize the laboratories with the procedure(s) and to estimate the methods' limits of detection/quantitation (LODs/LOQs). Synthetically generated samples of a semisynthetic MWF aerosol were then collected on tared polytetrafluoroethylene (PTFE) filters and analyzed according to the methods by all participants. Sample masses deposited (∼ 400-500 μ g) corresponded to amounts expected in an 8-hr shift at the NIOSH recommended exposure levels (REL) of 0.4 mg/m3 (thoracic) and 0.5 mg/m3 (total particulate). The generator output was monitored with a calibrated laser particle counter. One laboratory significantly underreported the sampled masses relative to the other five labs. A follow-up study compared only gravimetric results of this laboratory with those of two other labs. In the preliminary analysis of blanks; the average LOQs were 0.094 mg for the total weight analysis and 0.136 mg for the extracted weight analyses. For the six-lab study, the average LOQs were 0.064 mg for the total weight analyses and 0.067 mg for the extracted weight analyses. Using ASTM conventions, h and k statistics were computed to determine the degree of consistency of each laboratory with the others. One laboratory experienced problems with precision but not bias. The precision estimates for the remaining five labs were not different statistically (α = 0.005) for either the total or extractable weights. For all six labs, the average fraction extracted was ≥0.94 (CV = 0.025). Pooled estimates of the total coefficients of variation of analysis were 0.13 for the total weight samples and 0.13 for the extracted weight samples. An overall method bias of -5% was determined by comparing the overall mean concentration reported by the participants to that determined by the particle counter. In the three-lab follow-up study, the nonconsistent lab reported results that were unbiased but statistically less precise than the others; the average LOQ was 0.133 mg for the total weight analyses. It is concluded that aerosolized MWF sampled at concentrations corresponding to either of the NIOSH RELs can generally be shipped unrefrigerated, stored refrigerated up to 7 days, and then analyzed quantitatively and precisely for MWF using the NIOSH/ASTM procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toluene
KW - Dichloromethane
KW - Methanol
KW - Aerosols (Sprays)
KW - Metalworking lubricants
KW - ASTM Method D-7049-04
KW - limits of detection and quantitation
KW - metalworking fluids
KW - NIOSH method 5524
KW - performance evaluation
KW - storability
N1 - Accession Number: 75127792; Glaser, Robert 1; Kurimo, Robert 1; Shulman, Stanley 1; Affiliations: 1: National Institute for Occupational Safety and Health. Cincinnati, Ohio; Issue Info: Aug2007, Vol. 4 Issue 8, p583; Thesaurus Term: Toluene; Thesaurus Term: Dichloromethane; Thesaurus Term: Methanol; Thesaurus Term: Aerosols (Sprays); Subject Term: Metalworking lubricants; Author-Supplied Keyword: ASTM Method D-7049-04; Author-Supplied Keyword: limits of detection and quantitation; Author-Supplied Keyword: metalworking fluids; Author-Supplied Keyword: NIOSH method 5524; Author-Supplied Keyword: performance evaluation; Author-Supplied Keyword: storability; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325998 All Other Miscellaneous Chemical Product and Preparation Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 13p; Illustrations: 1 Diagram, 7 Graphs; Document Type: Article
L3 - 10.1080/15459620701473281
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DB - eih
ER -
TY - JOUR
AU - Blade, L. M.
AU - Yencken, M. Story
AU - Wallace, M. E.
AU - Catalano, J. D.
AU - Khan, A.
AU - Topmiller, J. L.
AU - Shulman, S. A.
AU - Martinez, A.
AU - Crouch, K. G.
AU - Bennett, J. S.
T1 - Hexavalent Chromium Exposures and Exposure-Control Technologies in American Enterprise: Results of a NIOSH Field Research Study.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/08//
VL - 4
IS - 8
M3 - Article
SP - 596
EP - 618
PB - Taylor & Francis Ltd
SN - 15459624
AB - The National Institute for Occupational Safety and Health (NIOSH) conducted 21 field surveys in selected industries to characterize workers' exposures to hexavalent chromium-containing airborne particulate and to evaluate existing technologies for controlling these exposures. Hexavalent chromium Cr(VI) is a respiratory irritant and chronic inhalation may cause lung cancer. Primary evaluation methods included collection of full work shift, personal breathing-zone (PBZ) air samples for Cr(VI), measurement of ventilation system parameters, and documentation of processes and work practices. This study emphasized evaluation of engineering exposure control measures, so PBZ exposures were measured on the outside of personal protective equipment, for example, respirators. Field surveys were conducted in two chromium electroplating facilities, including one where full-shift PBZ exposures to Cr(VI) ranged from 3.0 to 16 times the 1 μ g/m3NIOSH recommended exposure limit (REL) despite several engineering controls on the plating tanks. At a painting and coating facility that used Cr(VI)-containing products, full-shift exposures of painters and helpers (2.4 to 55 μ g/m3) exceeded the REL, but LEV effectiveness was limited. Other operations evaluated included welding in construction; metal cutting operations on chromium-containing materials in ship breaking; chromate-paint removal with abrasive blasting; atomized alloy-spray coating; foundry operations; printing; and the manufacture of refractory brick, colored glass, prefabricated concrete products, and treated wood products. NIOSH researchers concluded that, in many of the evaluated processes, Cr(VI) exposures at or below the current NIOSH REL are achievable. However, for some processes, it is unclear whether controlling exposures to this range is consistently achievable without respirator use. Some operations involving the application of coatings and finishes may be among those most difficult to control to this range. Most operations judged to be moderately difficult to control to this range involve joining and cutting metals with relatively high chromium content. Nonetheless, exposures in a wide variety of other processes were judged more easily controllable to the current REL or below, or were found to be minimal, including some operations meeting the general descriptions named above but with different specific operating parameters producing lower Cr(VI) exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hexavalent chromium
KW - Respiration
KW - Concrete products
KW - Business enterprises -- United States
KW - United States
KW - chromium
KW - engineering controls
KW - exposure assessment
KW - exposure controls
KW - field study
KW - hexavalent chromium
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 75127791; Blade, L. M. 1; Yencken, M. Story 2; Wallace, M. E. 2; Catalano, J. D. 2; Khan, A. 1; Topmiller, J. L. 1; Shulman, S. A. 1; Martinez, A. 3; Crouch, K. G. 1; Bennett, J. S. 1; Affiliations: 1: National Institute for Occupational Safety and Health. Cincinnati, Ohio; 2: Battelle Centers for Public Health Research and Evaluation. Seattle. Washington; 3: Los Alamos National Laboratory. Los Alamos, New Mexico; Issue Info: Aug2007, Vol. 4 Issue 8, p596; Thesaurus Term: Hexavalent chromium; Thesaurus Term: Respiration; Subject Term: Concrete products; Subject Term: Business enterprises -- United States; Subject: United States; Author-Supplied Keyword: chromium; Author-Supplied Keyword: engineering controls; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: exposure controls; Author-Supplied Keyword: field study; Author-Supplied Keyword: hexavalent chromium ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 416390 Other specialty-line building supplies merchant wholesalers; NAICS/Industry Codes: 327390 Other Concrete Product Manufacturing; NAICS/Industry Codes: 238120 Structural Steel and Precast Concrete Contractors; Number of Pages: 23p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15459620701463183
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106017763
T1 - Review of chamber design requirements for testing of personal protective clothing ensembles.
AU - Gao P
AU - King WP
AU - Shaffer R
Y1 - 2007/08//
N1 - Accession Number: 106017763. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; tables/charts. Note: For CE see Suppl pages D78-80. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Materials Testing -- Equipment and Supplies
KW - Protective Clothing -- Standards
KW - Aerosols
KW - Air Pollutants -- Pharmacokinetics
KW - Allergens
KW - Education, Continuing (Credit)
KW - Environmental Exposure -- Prevention and Control
KW - Equipment Failure
KW - Materials Testing -- Methods
SP - 562
EP - 571
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This review focuses on the physical requirements for conducting ensemble testing and describes the salient issues that organizations involved in the design, test, or certification of personal protective equipment (PPE) and protective clothing ensembles need to consider for strategic planning. Several current and proposed PPE ensemble test practices and standards were identified. The man-in-simulant test (MIST) is the primary procedure used by the military to evaluate clothing ensembles for protection against chemical and biological warfare agents. MIST has been incorporated into the current editions of protective clothing and equipment standards promulgated by the National Fire Protection Association (NFPA). ASTM has recently developed a new test method (ASTM F 2588-06) for MIST evaluation of protective ensembles. Other relevant test methods include those described in International Organization for Standardization (ISO) standards. The primary differences among the test methods were the choice of test challenge material (e.g., sulfur hexafluoride, methyl salicylate, sodium chloride particles, corn oil, fluorophore-impregnated silica) and the exercise protocol for the subject(s). Although ensemble test methods and standards provide detailed descriptions of the test procedures, none give specific requirements for chamber design. A literature survey identified 28 whole-body exposure chambers that have been or could potentially be used for testing protective clothing ensembles using human test subjects. Median chamber size, median floor space, and median volume per subject were calculated from 15 chambers (involving human test subjects), where size information is available. Based on the literature survey of existing chambers and the review of the current and proposed standards and test methods, chamber design requirements will be dictated by the test methods selected. Due to widely different test conditions for aerosol/particulate and vapor ensemble testing, it is unlikely that a single chamber could accommodate all types of ensemble testing. With increasing use of the MIST protocol by NFPA for CBRN certification of structural firefighting gear and protective ensembles for first responders, the need for MIST laboratory capability is clear. However, existing chambers can likely be adapted to accommodate MIST with some modifications.
SN - 1545-9624
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania.
U2 - PMID: 17558802.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 106017765
T1 - Performance testing of NIOSH Method 5524/ASTM Method D-7049-04, for determination of metalworking fluids.
AU - Glaser R
AU - Kurimo R
AU - Shulman S
Y1 - 2007/08//
N1 - Accession Number: 106017765. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D78-80. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Environmental Monitoring -- Methods
KW - Oils -- Analysis
KW - Aerosols
KW - Education, Continuing (Credit)
KW - Metallurgy
KW - National Institute for Occupational Safety and Health
KW - Physics
KW - Reproducibility of Results
KW - United States
KW - Human
SP - 583
EP - 595
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A performance test of NIOSH Method 5524/ASTM Method D-7049-04 for analysis of metalworking fluids (MWF) was conducted. These methods involve determination of the total and extractable weights of MWF samples; extractions are performed using a ternary blend of toluene:dichloromethane:methanol and a binary blend of methanol:water. Six laboratories participated in this study. A preliminary analysis of 20 blank samples was made to familiarize the laboratories with the procedure(s) and to estimate the methods' limits of detection/quantitation (LODs/LOQs). Synthetically generated samples of a semisynthetic MWF aerosol were then collected on tared polytetrafluoroethylene (PTFE) filters and analyzed according to the methods by all participants. Sample masses deposited ( approximately 400-500 mu g) corresponded to amounts expected in an 8-hr shift at the NIOSH recommended exposure levels (REL) of 0.4 mg/m(3) (thoracic) and 0.5 mg/m(3) (total particulate). The generator output was monitored with a calibrated laser particle counter. One laboratory significantly underreported the sampled masses relative to the other five labs. A follow-up study compared only gravimetric results of this laboratory with those of two other labs. In the preliminary analysis of blanks; the average LOQs were 0.094 mg for the total weight analysis and 0.136 mg for the extracted weight analyses. For the six-lab study, the average LOQs were 0.064 mg for the total weight analyses and 0.067 mg for the extracted weight analyses. Using ASTM conventions, h and k statistics were computed to determine the degree of consistency of each laboratory with the others. One laboratory experienced problems with precision but not bias. The precision estimates for the remaining five labs were not different statistically (alpha = 0.005) for either the total or extractable weights. For all six labs, the average fraction extracted was >/=0.94 (CV = 0.025). Pooled estimates of the total coefficients of variation of analysis were 0.13 for the total weight samples and 0.13 for the extracted weight samples. An overall method bias of -5% was determined by comparing the overall mean concentration reported by the participants to that determined by the particle counter. In the three-lab follow-up study, the nonconsistent lab reported results that were unbiased but statistically less precise than the others; the average LOQ was 0.133 mg for the total weight analyses. It is concluded that aerosolized MWF sampled at concentrations corresponding to either of the NIOSH RELs can generally be shipped unrefrigerated, stored refrigerated up to 7 days, and then analyzed quantitatively and precisely for MWF using the NIOSH/ASTM procedures.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health. Cincinnati, Ohio.
U2 - PMID: 17577749.
DO - 10.1080/15459620701473281
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DB - rzh
ER -
TY - JOUR
ID - 106017766
T1 - Hexavalent chromium exposures and exposure-control technologies in American enterprise: results of a NIOSH field research study.
AU - Blade LM
AU - Yencken MS
AU - Wallace ME
AU - Catalano JD
AU - Khan A
AU - Topmiller JL
AU - Shulman SA
AU - Martinez A
AU - Crouch KG
AU - Bennett JS
Y1 - 2007/08//
N1 - Accession Number: 106017766. Language: English. Entry Date: 20071207. Revision Date: 20150711. Publication Type: Journal Article; CEU; exam questions; research; tables/charts. Note: For CE see Suppl pages D78-80. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: OSHA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Chromium -- Analysis
KW - Occupational Exposure -- Analysis
KW - Education, Continuing (Credit)
KW - Electrolysis
KW - Environmental Exposure -- Analysis
KW - Environmental Exposure -- Prevention and Control
KW - Environmental Monitoring
KW - Funding Source
KW - Industry
KW - National Institute for Occupational Safety and Health
KW - Occupational Exposure -- Prevention and Control
KW - Paint
KW - Respiratory Protective Devices
KW - United States
KW - Ventilation
KW - Human
SP - 596
EP - 618
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 8
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety and Health (NIOSH) conducted 21 field surveys in selected industries to characterize workers' exposures to hexavalent chromium-containing airborne particulate and to evaluate existing technologies for controlling these exposures. Hexavalent chromium Cr(VI) is a respiratory irritant and chronic inhalation may cause lung cancer. Primary evaluation methods included collection of full work shift, personal breathing-zone (PBZ) air samples for Cr(VI), measurement of ventilation system parameters, and documentation of processes and work practices. This study emphasized evaluation of engineering exposure control measures, so PBZ exposures were measured on the outside of personal protective equipment, for example, respirators. Field surveys were conducted in two chromium electroplating facilities, including one where full-shift PBZ exposures to Cr(VI) ranged from 3.0 to 16 times the 1 mu g/m(3)NIOSH recommended exposure limit (REL) despite several engineering controls on the plating tanks. At a painting and coating facility that used Cr(VI)-containing products, full-shift exposures of painters and helpers (2.4 to 55 mu g/m(3)) exceeded the REL, but LEV effectiveness was limited. Other operations evaluated included welding in construction; metal cutting operations on chromium-containing materials in ship breaking; chromate-paint removal with abrasive blasting; atomized alloy-spray coating; foundry operations; printing; and the manufacture of refractory brick, colored glass, prefabricated concrete products, and treated wood products. NIOSH researchers concluded that, in many of the evaluated processes, Cr(VI) exposures at or below the current NIOSH REL are achievable. However, for some processes, it is unclear whether controlling exposures to this range is consistently achievable without respirator use. Some operations involving the application of coatings and finishes may be among those most difficult to control to this range. Most operations judged to be moderately difficult to control to this range involve joining and cutting metals with relatively high chromium content. Nonetheless, exposures in a wide variety of other processes were judged more easily controllable to the current REL or below, or were found to be minimal, including some operations meeting the general descriptions named above but with different specific operating parameters producing lower Cr(VI) exposures.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio.
U2 - PMID: 17577750.
DO - 10.1080/15459620701463183
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106017766&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105988232
T1 - Longitudinal trends of alcohol and tobacco consumption among Australian physicians and nurses, 1989-2005.
AU - Smith DR
Y1 - 2007/08//
N1 - Accession Number: 105988232. Language: English. Entry Date: 20080222. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. Special Interest: Psychiatry/Psychology. NLM UID: 100891385.
KW - Alcohol Drinking -- Epidemiology -- Australia
KW - Alcohol Drinking -- Trends
KW - Health Behavior
KW - Nurses
KW - Physicians
KW - Smoking -- Epidemiology -- Australia
KW - Smoking -- Trends
KW - Adolescence
KW - Adult
KW - Australia
KW - Comparative Studies
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Epidemiological Research
KW - Female
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - Prospective Studies
KW - Relative Risk
KW - Substance Abuse -- Epidemiology
KW - Surveys
KW - Trend Studies
KW - Human
SP - 267
EP - 280
JO - Journal of Substance Use
JF - Journal of Substance Use
JA - J SUBST USE
VL - 12
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Aim: This study examined alcohol and tobacco consumption trends among a national sample of Australian health care workers between 1989 and 2005. Method: Alcohol and tobacco smoking data specific for physicians and nurses was obtained during four national health surveys. Data were analysed by alcohol consumption level, tobacco smoking status, job category and year of study. The relative risk of substance use between physicians, nurses and the general Australian population was also evaluated. Results: The proportion of Australian physicians and nurses with risky alcohol consumption habits appears to have fluctuated over time, particularly among nurses. Although tobacco smoking among Australian nurses has declined in recent years, the relatively low proportion of physician smokers remained fairly stable over the same time period. Both professional groups were considerably less likely to use tobacco when compared with the general population. Conclusion: This study provides one of the first clear insights into longitudinal substance use trends among Australian health care workers during the past 17 years. A sustained reduction in alcohol and tobacco use must continue in future, so that they remain exemplars at the forefront of anti-substance abuse programmes in the community.
SN - 1465-9891
AD - International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105988232&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hyung Soo Kim
AU - Eom, Juno H.
AU - Hye-young Cho
AU - Young Joo Cho
AU - Ji Young Kim
AU - Jong Kwon Lee
AU - Seung-Hee Kim
AU - Kui Lea Park
T1 - Evaluation of Immunotoxicity Induced by Pirimiphos-methyl in Male Balb/c Mice Following Exposure to for 28 Days.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/08//
VL - 70
IS - 15/16
M3 - Article
SP - 1278
EP - 1287
SN - 15287394
AB - Pirimiphos-methyl (O-2-diethylamino-6-methylpyrimidin-4-yl O,O-dimethyl phosphorothioate: POM) is widely used organophosphorous(OP) insecticide as a grain protectant to control insects during storage. This study was carried out to assess the immunologic effects of POM in Balb/c mice after 28-day oral exposure. Three dose levels of POM (10, 60, or 120 mg/kg/day) were administered orally to mice for 4 weeks. At autopsy after 28-day exposure, there were significant decreases in relative spleen weight and splenic cellularity found at 120 mg POM, but body weight, relative thymic weight, thymic cellularity, and splenic and thymic subsets were not affected. T cell proliferation response induced by Con A was significantly decreased at all dosages though no statistical differences were observed in splenic B cell proliferation. Significant increases in the production of cytokines (IL-2, IL-4, IL-6, IFN- γ, and IL-10) were evident on the whole, but the increase in production of inflammatory cytokines overwhelmed that of the TH1 cell suppressive cytokine (IL-10). The relative levels of three types of autoantibodies, anti-dsDNA, anti-histone, and antinuclear antibody (ANA) were dose-dependently decreased in serum. Oral exposure to POM induced a significant decrease in Immunoglobulin M production capability in Balb/c mice. This decrease in antibody production capability may result from disturbances in cytokine balance produced by splenic immune cells. These results show that POM may induce allergic responses by relatively enhancing TH2 development and additionally contribute to chronic inflammation by attracting macrophage by IFN-γ. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANOPHOSPHORUS compounds
KW - INSECTICIDES
KW - IMMUNOTOXICOLOGY
KW - CYTOKINES
KW - INTERLEUKINS
KW - T cells
N1 - Accession Number: 25915445; Hyung Soo Kim 1 Eom, Juno H. 1 Hye-young Cho 1 Young Joo Cho 1 Ji Young Kim 1 Jong Kwon Lee 1 Seung-Hee Kim 1; Email Address: kim_hs@kfda.go.kr Kui Lea Park 1; Affiliation: 1: Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Aug2007, Vol. 70 Issue 15/16, p1278; Subject Term: ORGANOPHOSPHORUS compounds; Subject Term: INSECTICIDES; Subject Term: IMMUNOTOXICOLOGY; Subject Term: CYTOKINES; Subject Term: INTERLEUKINS; Subject Term: T cells; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 10p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390701434372
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25915445&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keunho Kim
AU - Tae Gen Son
AU - So Jung Kim
AU - Hyung Sik Kim
AU - Tae Sung Kim
AU - Soon Young Han
AU - Jaewon Lee
T1 - Suppressive Effects of Bisphenol A on the Proliferation of Neural Progenitor Cells.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/08//
VL - 70
IS - 15/16
M3 - Article
SP - 1288
EP - 1295
SN - 15287394
AB - Endocrine disruptors (EDs) exert adverse effects on reproductive and immune function or neurological behavior. Bisphenol A (BPA), one of the environmental EDs, is widely used in the manufacture of plastics and epoxy resins. Studies reported that BPA affects reproductive organ growth and development. However, the potential adverse effects of BPA on neuronal development have not been fully explored. In this study, the potent harmful effects of BPA were investigated on the murine-derived multipotent neural progenitor cells (NPCs). Pretreatment of BPA significantly decreased proliferation of NPCs in a concentration-dependent manner. Moreover, at a high concentration (> 400 μM), BPA was cytotoxic to NPCs. However, the low concentrations of BPA, previously shown to exert estrogenic actions, did not affect the proliferation of NPCs. BPA altered the activation of extracellular signal-regulated kinases and c-Jun-N-Kinases in a different manner without affecting activities of p38 kinases. It was also found that reactive oxygen species (ROS) were elevated in NPCs exposed to high concentrations of BPA, indicating oxidative stress-related cytotoxicity. These data show adverse effects of BPA on the nervous system and potentially on neonatal brain development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BISPHENOL A
KW - ENDOCRINE disruptors
KW - CELL proliferation
KW - NEURAL development
KW - NEURONS
KW - ACTIVE oxygen
N1 - Accession Number: 25915444; Keunho Kim 1 Tae Gen Son 1 So Jung Kim 1 Hyung Sik Kim 1 Tae Sung Kim 2 Soon Young Han 2 Jaewon Lee 1; Email Address: neuron@pusan.ac.kr; Affiliation: 1: Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong-gu, Busan, Republic of Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Aug2007, Vol. 70 Issue 15/16, p1288; Subject Term: BISPHENOL A; Subject Term: ENDOCRINE disruptors; Subject Term: CELL proliferation; Subject Term: NEURAL development; Subject Term: NEURONS; Subject Term: ACTIVE oxygen; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390701434216
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25915444&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ju Young Ryu
AU - Jung Whang
AU - Hyeyoung Park
AU - Ji Young Im
AU - Jeonga Kim
AU - Mee Young Ahn
AU - Jaewon Lee
AU - Hyung Sik Kim
AU - Byung Mu Lee
AU - Sun Dong Yoo
AU - Seung Jun Kwack
AU - Jae Ho Oh
AU - Kui Lea Park
AU - Soon Young Han
AU - Seung Hee Kim
T1 - Di(2-ethylhexyl) Phthalate Induces Apoptosis Through Peroxisome Proliferators-Activated Receptor-Gamma and ERK 1/2 Activation in Testis of Sprague-Dawley Rats.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/08//
VL - 70
IS - 15/16
M3 - Article
SP - 1296
EP - 1303
SN - 15287394
AB - Di(2-ethylhexyl) phthalate (DEHP) is a well-known hepatic and reproductive toxicant whose toxicity may be mediated by peroxisome proliferators-activated receptor (PPAR). This study examined the effects of DEHP on the expression of PPAR-regulated genes involved in testicular cells apoptosis. Sprague-Dawley male rats were treated orally with 250, 500, or 750 mg/kg/d DEHP for 28 d, while control rats were given corn oil. The levels of cell cycle regulators (pRb, cyclins, CDKs, and p21) and apoptosis-related proteins were analyzed by Western blot analysis. The role of PPAR-gamma (PPAR-γ), class B scavenger receptor type 1 (SR-B1), and ERK1/2 was further studied to examine the signaling pathway for DEHP-induced apoptosis. Results showed that the levels of pRB, cyclin D, CDK2, cyclin E, and CDK4 were significantly lower in rats given 500 and 750 mg/kg/d DEHP, while levels of p21 were significantly higher in rat testes. Dose-dependent increases in PPAR-γ and RXRα proteins were observed in testes after DEHP exposure, while there was a significant decrease in RXRγ protein levels. In addition to PPAR-γ, DEHP also significantly increased SR-B1 mRNA and phosphorylated ERK1/2 protein levels. Furthermore, DEHP treatment induced pro-caspase-3 and cleavage of its substrate protein, poly(ADP-ribose) polymerase (PARP), in a dose-dependent manner. Data suggest that DEHP exposure may induce the expression of apoptosis-related genes in testes through induction of PPAR-γ and activation of the ERK1/2 pathway. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHTHALATE esters
KW - APOPTOSIS
KW - GENE expression
KW - TESTIS
KW - PEROXISOMES
KW - WESTERN immunoblotting
N1 - Accession Number: 25915443; Ju Young Ryu 1 Jung Whang 1 Hyeyoung Park 1 Ji Young Im 1 Jeonga Kim 1 Mee Young Ahn 1 Jaewon Lee 1 Hyung Sik Kim 1 Byung Mu Lee 2 Sun Dong Yoo 2 Seung Jun Kwack 3 Jae Ho Oh 3 Kui Lea Park 3 Soon Young Han 3 Seung Hee Kim 3; Email Address: hkims@pusan.ac.kr; Affiliation: 1: College of Pharmacy, Pusan National University, Pusan, Republic of Korea 2: College of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul, Republic of Korea; Source Info: Aug2007, Vol. 70 Issue 15/16, p1296; Subject Term: PHTHALATE esters; Subject Term: APOPTOSIS; Subject Term: GENE expression; Subject Term: TESTIS; Subject Term: PEROXISOMES; Subject Term: WESTERN immunoblotting; Number of Pages: 8p; Illustrations: 5 Black and White Photographs, 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1080/15287390701432160
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25915443&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schoenman, Julie A.
AU - Sutton, Janet P.
AU - Elixhauser, Anne
AU - Love, Denise
T1 - Understanding and Enhancing the Value of Hospital Discharge Data.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2007/08//
VL - 64
IS - 4
M3 - Article
SP - 449
EP - 468
SN - 10775587
AB - This work summarizes how hospital discharge data are used, identifies strengths and shortcomings, and presents suggestions for enhancing usefulness of the data. Results demonstrate that discharge data are used in a wide range of applications by diverse users. Uses include public health and population-based applications, as well as quality assessment, informed purchasing, strategic planning, and policymaking. Strategies to enhance the utility of discharge data include: improving the quality of existing data elements and adding new data elements that will support more advanced analyses, improving linkages with data from nonhospital settings and databases outside health care, and developing a technical assistance network to support statewide data organizations in their efforts to collect and analyze discharge data. As our nation moves toward universal electronic medical records, it will be important to keep in mind the many uses of discharge data in order to maintain the data capacity to fill these needs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL records
KW - PUBLIC health
KW - PUBLIC health surveillance
KW - QUALITY
KW - PURCHASING
KW - PLANNING
KW - hospital administrative data
KW - informed purchasing
KW - injury/disease surveillance
KW - inpatient discharge data
KW - public health
KW - quality improvement
KW - state inpatient data
N1 - Accession Number: 26075440; Schoenman, Julie A. 1; Email Address: schoenman-julie@norc.uchicago.edu Sutton, Janet P. 1 Elixhauser, Anne 2 Love, Denise 3; Affiliation: 1: NORC, University of Chicago 2: The Agency for Healthcare Research and Quality 3: The National Association of Health Data Organizations; Source Info: Aug2007, Vol. 64 Issue 4, p449; Subject Term: MEDICAL records; Subject Term: PUBLIC health; Subject Term: PUBLIC health surveillance; Subject Term: QUALITY; Subject Term: PURCHASING; Subject Term: PLANNING; Author-Supplied Keyword: hospital administrative data; Author-Supplied Keyword: informed purchasing; Author-Supplied Keyword: injury/disease surveillance; Author-Supplied Keyword: inpatient discharge data; Author-Supplied Keyword: public health; Author-Supplied Keyword: quality improvement; Author-Supplied Keyword: state inpatient data; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 20p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baker, Brent A.
AU - Mercer, Robert R.
AU - Geronilla, Ken B.
AU - Kashon, Michael L.
AU - Miller, Gerald R.
AU - Cutlip, Robert G.
T1 - Impact of Repetition Number on Muscle Performance and Histological Response.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2007/08//
VL - 39
IS - 8
M3 - Article
SP - 1275
EP - 1281
SN - 01959131
AB - This article presents a study about the impact of repetition number on muscle performance and histological response. Skeletal muscle injury is major interest in sport-related and occupation-related fields. It investigates the effects of increasing stretch-shortening contraction repetition number and the resulting changes in functional performance and quantitative morphometry in rat skeletal muscle. The findings suggests that exposure to increasing stretch-shortening contraction repetitions results in increased functional decrements and morphometric indices of myofiber degeneration and inflammation.
KW - MUSCLES
KW - SPORTS
KW - MUSCLES -- Wounds & injuries
KW - MYOSITIS
KW - BONES
KW - MUSCULOSKELETAL system
KW - SKELETON
KW - MUSCLE contraction
KW - RESEARCH
KW - DORSIFLEXOR MUSCLES
KW - IN VIVO
KW - MUSCLE INJURY
KW - STEREOLOGY
N1 - Accession Number: 26226580; Baker, Brent A. 1 Mercer, Robert R. 1 Geronilla, Ken B. 1 Kashon, Michael L. 1 Miller, Gerald R. 1 Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV; Source Info: Aug2007, Vol. 39 Issue 8, p1275; Subject Term: MUSCLES; Subject Term: SPORTS; Subject Term: MUSCLES -- Wounds & injuries; Subject Term: MYOSITIS; Subject Term: BONES; Subject Term: MUSCULOSKELETAL system; Subject Term: SKELETON; Subject Term: MUSCLE contraction; Subject Term: RESEARCH; Author-Supplied Keyword: DORSIFLEXOR MUSCLES; Author-Supplied Keyword: IN VIVO; Author-Supplied Keyword: MUSCLE INJURY; Author-Supplied Keyword: STEREOLOGY; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 4 Graphs; Document Type: Article
L3 - 10.1249/mss.0b013e3180686dc7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26226580&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105996709
T1 - Impact of repetition number on muscle performance and histological response.
AU - Baker BA
AU - Mercer RR
AU - Geronilla KB
AU - Kashon ML
AU - Miller GR
AU - Cutlip RG
Y1 - 2007/08//
N1 - Accession Number: 105996709. Language: English. Entry Date: 20080222. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Physical Therapy; Sports Medicine. NLM UID: 8005433.
KW - Ankle -- Physiology
KW - Isometric Contraction -- Physiology
KW - Muscle, Skeletal -- Physiology
KW - Stretching
KW - Animals
KW - Male
KW - Random Assignment
KW - Rats
KW - United States
KW - Animal Studies
SP - 1275
EP - 1281
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
JA - MED SCI SPORTS EXERC
VL - 39
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Skeletal muscle injury is major concern in sport- and occupation-related fields. Purpose: We investigated the effects of increasing stretch-shortening contraction (SSC) repetition number in vivo and the resulting changes in functional performance and quantitative morphometry in rat skeletal muscle. Methods: Functional testing was performed on the ankle dorsiflexor muscles of Sprague-Dawley rats, which were randomly exposed to 30 SSC, 70 SSC, 150 SSC, or 15 isometric contractions of equal duration. Changes in functional performance and muscle morphometry were assessed at 48 h after exposure. Stereology was used to quantify the volume density of degenerative myofibers and normal myofibers in the tibialis anterior muscle from each group, as well as measures of inflammation and swelling and changes in the interstitial space. Results: At 48 h there was a significant decline in isometric force for the 70- and 150-SSC groups (P < 0.05 and P < 0.05, respectively). Stereological measures indicated significant decreases in the percentage of volume density of normal myofibers in the 70- and 150-SSC groups (P < 0.05). Measures for percentage of volume density of degenerative myofibers and inflammation were increased (P < 0.0001 and P < 0.05, respectively) in the 70- and 150-SSC groups. Moreover, a significant increase in the percentage of volume density of degenerative myofibers in the 150-SSC group compared with the 70-SSC group was observed (P < 0.05). Conclusion: These data strongly suggest that exposure to increasing SSC repetitions results in increased functional decrements and morphometric indices of myofiber degeneration and inflammation, and that there is an apparent threshold (repetition number) at which this occurs.
SN - 0195-9131
AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV; rgc8@cdc.gov
U2 - PMID: 17762360.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105996709&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Monday, S.R.
AU - Beisaw, A.
AU - Feng, P.C.H.
T1 - Identification of Shiga toxigenic Escherichia coli seropathotypes A and B by multiplex PCR
JO - Molecular & Cellular Probes
JF - Molecular & Cellular Probes
Y1 - 2007/08//
VL - 21
IS - 4
M3 - Article
SP - 308
EP - 311
SN - 08908508
AB - Abstract: A multiplex PCR assay was developed to identify the six clinically important enterohemorrhagic Escherichia coli (EHEC) serotypes classified in seropathotypes A and B and to differentiate these from Shiga toxigenic E. coli. The assay simultaneously detects genes for Shiga toxin (stx) and intimin (eae), including allelic variants of both genes, 16S internal amplification control, as well as unique sequences in the wzx genes that are specific for serotypes O157, O26, O111, O103, O121 and O145. PCR analysis of 40 representative strains showed that the assay correctly identified the virulence genes, if present, and the respective O antigen type of all the strains, including some atypical EHEC, as well as enteropathogenic E. coli and E. coli strains examined. [Copyright &y& Elsevier]
AB - Copyright of Molecular & Cellular Probes is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - ENTEROBACTERIACEAE
KW - ESCHERICHIA
KW - GENES
KW - Enterohemorrhagic E. coli
KW - Multiplex PCR
KW - Seropathotypes
N1 - Accession Number: 25031591; Monday, S.R. 1 Beisaw, A. 1 Feng, P.C.H.; Email Address: peter.feng@fda.hhs.gov; Affiliation: 1: Division of Microbiological Studies, US Food and Drug Administration, College Park, MD 20740, USA; Source Info: Aug2007, Vol. 21 Issue 4, p308; Subject Term: ESCHERICHIA coli; Subject Term: ENTEROBACTERIACEAE; Subject Term: ESCHERICHIA; Subject Term: GENES; Author-Supplied Keyword: Enterohemorrhagic E. coli; Author-Supplied Keyword: Multiplex PCR; Author-Supplied Keyword: Seropathotypes; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.mcp.2007.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25031591&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volokhov, Dmitriy V.
AU - Neverov, Alexander A.
AU - George, Joseph
AU - Kong, Hyesuk
AU - Liu, Sue X.
AU - Anderson, Christine
AU - Davidson, Maureen K.
AU - Chizhikov, Vladimir
T1 - Genetic analysis of housekeeping genes of members of the genus Acholeplasma: Phylogeny and complementary molecular markers to the 16S rRNA gene
JO - Molecular Phylogenetics & Evolution
JF - Molecular Phylogenetics & Evolution
Y1 - 2007/08//
VL - 44
IS - 2
M3 - Article
SP - 699
EP - 710
SN - 10557903
AB - Abstract: The partial nucleotide sequences of the rpoB and gyrB genes as well as the complete sequence of the 16S–23S rRNA intergenic transcribed spacer (ITS) were determined for all known Acholeplasma species. The same genes of Mesoplasma and Entomoplasma species were also sequenced and used to infer phylogenetic relationships among the species within the orders Entomoplasmatales and Acholeplasmatales. The comparison of the ITS, rpoB, and gyrB phylogenetic trees with the 16S rRNA phylogenetic tree revealed a similar branch topology suggesting that the ITS, rpoB, and gyrB could be useful complementary phylogenetic markers for investigation of evolutionary relationships among Acholeplasma species. Thus, the multilocus phylogenetic analysis of Acholeplasma multilocale sequence data (ATCC 49900 (T)=PN525 (NCTC 11723)) strongly indicated that this organism is most closely related to the genera Mesoplasma and Entomoplasma (family Entomoplasmataceae) and form the branch with Mesoplasma seiffertii, Mesoplasma syrphidae, and Mesoplasma photuris. The closest genetic relatedness of this species to the order Entomoplasmatales was additionally supported by the finding that A. multilocale uses UGA as the tryptophan codon in its gyrB and gyrA sequences. Use of the UGA codon for encoding tryptophan was previously reported as a unique genetic feature of Entomoplasmatales and Mycoplasmatales but not of Acholeplasmatales. These data, as well as previously published data on metabolic features of A. multilocale, leads to the proposal to reclassify A. multilocale as a member of the family Entomoplasmataceae. [Copyright &y& Elsevier]
AB - Copyright of Molecular Phylogenetics & Evolution is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYLOGENY
KW - RNA
KW - MYCOPLASMATALES
KW - NUCLEOTIDE sequence
KW - Mollicutes
KW - Mycoplasmas
KW - rpoB and gyrB genes
N1 - Accession Number: 25745863; Volokhov, Dmitriy V. 1; Email Address: dmitriy.volokhov@fda.hhs.gov Neverov, Alexander A. 1 George, Joseph 1 Kong, Hyesuk 1 Liu, Sue X. 1 Anderson, Christine 1 Davidson, Maureen K. 2 Chizhikov, Vladimir 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, USA 2: Department of Veterinary Pathobiology, Purdue University School of Veterinary Medicine, 725 Harrison Street, West Lafayette, IN 47907, USA; Source Info: Aug2007, Vol. 44 Issue 2, p699; Subject Term: PHYLOGENY; Subject Term: RNA; Subject Term: MYCOPLASMATALES; Subject Term: NUCLEOTIDE sequence; Author-Supplied Keyword: Mollicutes; Author-Supplied Keyword: Mycoplasmas; Author-Supplied Keyword: rpoB and gyrB genes; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ympev.2006.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kreiss, Kathleen
T1 - Emerging opportunities to prevent occupational lung disease.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2007/08//
VL - 64
IS - 8
M3 - Editorial
SP - 499
EP - 500
SN - 13510711
AB - The author reflects on the emerging opportunities that can help prevent occupational lung diseases. She states that opportunities to prevent occupational lung diseases require the discovery of new occupational lung diseases, new settings for recognized occupational lung diseases, and new approaches to their prevention. She adds that astute clinicians can play a vital role in suspecting an emerging occupational cause when they diagnose a rare disease or a cluster of more common or severe disease.
KW - Industrial hygiene
KW - Occupational diseases -- Prevention
KW - Lungs -- Cancer
KW - Preventive medicine
N1 - Accession Number: 26111480; Kreiss, Kathleen 1; Email Address: kkreiss@cdc.gov; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Aug2007, Vol. 64 Issue 8, p499; Thesaurus Term: Industrial hygiene; Subject Term: Occupational diseases -- Prevention; Subject Term: Lungs -- Cancer; Subject Term: Preventive medicine; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1136/oem.2006.029918
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105963434
T1 - FDA Drug Approval Summary: Pegaspargase (Oncaspar(R)) for the First-Line Treatment of Children with Acute Lymphoblastic Leukemia (ALL)
AU - Dinndorf PA
AU - Gootenberg J
AU - Cohen MH
AU - Keegan P
AU - Pazdur R
Y1 - 2007/08//
N1 - Accession Number: 105963434. Language: English. Entry Date: 20080208. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents -- Therapeutic Use
KW - Asparaginase -- Adverse Effects
KW - Asparaginase -- Therapeutic Use
KW - Leukemia, Lymphocytic, Acute -- Drug Therapy
KW - Antibodies -- Blood
KW - Antineoplastic Agents, Combined
KW - Asparaginase -- Antagonists and Inhibitors
KW - Asparaginase -- Blood
KW - Asparaginase -- Immunology
KW - Asparagine -- Blood
KW - Asparagine -- Cerebrospinal Fluid
KW - Child
KW - Child, Preschool
KW - Clinical Trials
KW - Drug Approval
KW - Female
KW - Infant
KW - Male
KW - Prognosis
KW - Treatment Outcomes
KW - United States Food and Drug Administration
KW - United States
KW - Human
SP - 991
EP - 998
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 12
IS - 8
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On July 24, 2006, the U.S. Food and Drug Administration granted approval to pegaspargase (Oncaspar(R); Enzon Pharmaceuticals, Inc., Bridgewater, NJ; hereafter, O) for the first-line treatment of patients with acute lymphoblastic leukemia (ALL) as a component of a multiagent chemotherapy regimen. O was previously approved in February 1994 for the treatment of patients with ALL who were hypersensitive to native forms of L-asparaginase. The trial supporting this new indication was an open label, randomized, multicenter clinical trial that enrolled 118 children (age, 1-9 years) with previously untreated, standard risk ALL. Patients received either native Escherichia coli asparaginase (Elspar(R); Merck, Whitehouse Station, NJ; hereafter, E) or O along with multiagent chemotherapy during remission induction and delayed intensification (DI) phases of treatment. O, at a dose of 2,500 IU/m(2), was administered i.m. on day 3 of the 4-week induction phase and on day 3 of each of two 8-week DI phases. E, at a dose of 6,000 IU/m(2), was administered i.m. three times weekly for nine doses during induction and for six doses during each DI phase. This study allowed direct comparison of O and E for asparagine depletion, asparaginase activity, and development of asparaginase antibodies. An unplanned comparison of event-free survival (EFS) was conducted to rule out a deleterious O efficacy effect. Following induction and DI treatment there was complete (0.03 IU/ml in O-treated subjects was greater than the number of days in E-treated subjects during both the induction and DI phases of treatment. There was no correlation, however, between asparaginase activity and serum asparagine levels, making the former determination less clinically relevant. Using the protocol-prespecified threshold for a positive result of >2.5 times the control, 7 of 56 (12%) O subjects tested at any time during the study demonstrated antiasparaginase antibodies and 16 of 57 (28%) E subjects tested at any time during the study had antiasparaginase antibodies. In both study arms EFS was in the range of 80% at 3 years. The most serious, sometimes fatal, O toxicities were anaphylaxis, other serious allergic reactions, thrombosis (including sagittal sinus thrombosis), pancreatitis, glucose intolerance, and coagulopathy. The most common adverse events were allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases. Disclosure of potential conflicts of interest is found at the end of this article.
SN - 1083-7159
AD - U.S. Food and Drug Administration, White Oak Campus, 10903 New Hampshire Avenue, Building 22, Room 2102, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov.
U2 - PMID: 17766659.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Knudsen, James F.
AU - Flowers, Charlene M.
AU - Kortepeter, Cindy
AU - Awaad, Yasser
T1 - Clinical Profile of Oxcarbazepine-Related Angioneurotic Edema: Case Report and Review
JO - Pediatric Neurology
JF - Pediatric Neurology
Y1 - 2007/08//
VL - 37
IS - 2
M3 - Article
SP - 134
EP - 137
SN - 08878994
AB - Oxcarbazepine, a carbamazepine analog, was approved for use as an antiepileptic agent in the United States in 2000. A search of the United States Food and Drug Administration’s Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger. We describe in detail the first U.S. case report, of a 4½-year-old boy who experienced angioedema during treatment with oxcarbazepine. The reporting rate for angioedema was calculated to be 9.8 cases per 1,000,000 pediatric patients. Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital. [Copyright &y& Elsevier]
AB - Copyright of Pediatric Neurology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBAMAZEPINE
KW - ANGIONEUROTIC edema
KW - JUVENILE diseases
KW - EDEMA
N1 - Accession Number: 26036912; Knudsen, James F. 1; Email Address: james.knudsen@fda.hhs.gov Flowers, Charlene M. 2 Kortepeter, Cindy 2 Awaad, Yasser 3; Affiliation: 1: Office of Drug Evaluation I, Division of Neurology Products, Food and Drug Administration, Silver Spring, Maryland 2: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, Maryland 3: Pediatric Neurology & Movement Disorders Program, Oakwood Healthcare System, Dearborn, Michigan.; Source Info: Aug2007, Vol. 37 Issue 2, p134; Subject Term: CARBAMAZEPINE; Subject Term: ANGIONEUROTIC edema; Subject Term: JUVENILE diseases; Subject Term: EDEMA; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.pediatrneurol.2007.03.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaplan, Sigal
AU - Staffa, Judy A.
AU - Dal Pan, Gerald J.
T1 - Duration of therapy with metoclopramide: a prescription claims data study.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/08//
VL - 16
IS - 8
M3 - Article
SP - 878
EP - 881
SN - 10538569
AB - Purpose Metoclopramide-induced tardive dyskinesia is associated with cumulative drug exposure, which can result from prolonged use of the drug. We estimated therapy duration with metoclopramide, and measured the extent of therapy beyond the maximum time period of 12 weeks evaluated in the clinical trials and recommended in the label. Methods Prescription claims for metoclopramide from 2002 to 2004 were extracted for participants residing throughout the US and contained within the Caremark pharmacy benefit manager (PBM) database. An episode of therapy was defined as one or a series of consecutive claims with no more than a 30-day lag between the dispensing date of a new claim and the ending date of the preceding claim. Episode duration was calculated by subtracting the start date from the end date for each episode. Results During the study period, almost 80% of participants (total = 200 907) had only one episode of therapy. The length of the longest episode for most patients (85%) varied from 1 to 90 days, yet 15% of the patients appeared to have received prescriptions for metoclopramide for a period longer than 90 days. Cumulative therapy for longer than 90 days was recorded for almost 20% of the patients. Conclusions These results suggest that despite the known risk of tardive dyskinesia and the labeled recommendations on duration of metoclopramide use, many patients appear to use the drug for relatively long time periods beyond the labeled recommendations. Physicians should carefully consider the risk-benefit profile of the drug and, if possible, avoid increased risk of tardive dyskinesia due to prolonged exposure. Published in 2007 by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64708145; Kaplan, Sigal 1; Staffa, Judy A. 1; Dal Pan, Gerald J. 1; Affiliations: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Aug2007, Vol. 16 Issue 8, p878; Number of Pages: 4p; Document Type: Article
L3 - 10.1002/pds.1397
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brennan, Michael J.
AU - Fruth, Uli
AU - Milstien, Julie
AU - Tiernan, Rosemary
AU - Nishioka, Sergio De Andrade
AU - Chocarro, Liliana
T1 - Development of New Tuberculosis Vaccines: A Global Perspective on Regulatory Issues.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2007/08//
VL - 4
IS - 8
M3 - Article
SP - e252
EP - 1302
PB - Public Library of Science
SN - 15491277
AB - What are the regulatory challenges for testing and introducing investigative TB vaccines into countries where the disease is endemic? [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Medicine is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS -- Vaccination
KW - VACCINES
KW - PHARMACEUTICAL research
KW - COMMUNICABLE diseases -- Prevention
KW - CHEST (Anatomy) -- Diseases
N1 - Accession Number: 26548291; Brennan, Michael J. 1; Email Address: Michael.Brennan@fda.hhs.gov Fruth, Uli 2 Milstien, Julie 3 Tiernan, Rosemary 4 Nishioka, Sergio De Andrade 5 Chocarro, Liliana 6; Affiliation: 1: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America 2: Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland 3: Department of Geographic Medicine, University of Maryland School of Medicine, Montpellier, France 4: Division of Vaccines and Related Product Applications, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America 5: Center for Surveillance of Adverse Events and Quality Deviations, National Health Surveillance Agency (ANVISA), Brasilia, Brazil 6: Regulatory Pathways, World Health Organization, Family and Community Health Cluster, Immunization, Vaccines and Biologicals, Access to Technologies, Geneva, Switzerland; Source Info: Aug2007, Vol. 4 Issue 8, pe252; Subject Term: TUBERCULOSIS -- Vaccination; Subject Term: VACCINES; Subject Term: PHARMACEUTICAL research; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: CHEST (Anatomy) -- Diseases; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1371/journal.pmed.0040252
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105923982
T1 - Rates of sexual victimization in prison for inmates with and without mental disorders.
AU - Wolff N
AU - Blitz CL
AU - Shi J
AU - Wolff, Nancy
AU - Blitz, Cynthia L
AU - Shi, Jing
Y1 - 2007/08//
N1 - Accession Number: 105923982. Language: English. Entry Date: 20080111. Revision Date: 20161125. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Instrumentation: State-Trait Anxiety Inventory (STAI) (Spielberger); Center for Epidemiologic Studies Depression Scale (CES-D); Short Form-36 Health Survey (SF-36). Grant Information: P20 MH 66170/MH/NIMH NIH HHS/United States. NLM UID: 9502838.
KW - Crime Victims
KW - Mental Disorders -- Epidemiology
KW - Prisoners
KW - Sex Offenders
KW - Adult
KW - Audiorecording
KW - Blacks -- Psychosocial Factors
KW - Center for Epidemiological Studies Depression Scale
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - DSM
KW - Female
KW - Funding Source
KW - Hispanics -- Psychosocial Factors
KW - Male
KW - Mid Atlantic Region
KW - Multicenter Studies
KW - Odds Ratio
KW - P-Value
KW - Power Analysis
KW - Psychological Tests
KW - Risk Factors
KW - Sample Size
KW - Scales
KW - Short Form-36 Health Survey (SF-36)
KW - State-Trait Anxiety Inventory
KW - Surveys
KW - Violence
KW - Whites -- Psychosocial Factors
KW - Wilcoxon Rank Sum Test
KW - Human
SP - 1087
EP - 1094
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 58
IS - 8
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Objective: This study estimated the rates of sexual victimization among prison inmates with and without a mental disorder.Methods: The study sampled inmates aged 18 or older in 13 prisons within a single mid-Atlantic state prison system (12 facilities for men and one for women). A total of 7,528 inmates completed the survey instrument, which was administered by audio-computer-assisted technology. Of the 6,964 male respondents, 58.5% were African American, 16.2% were non-Hispanic white, 19.8% were Hispanic, and 5.5% were of another race or ethnicity. Of the 564 female respondents, 48.4% were African American, 30.9% were non-Hispanic white, 14.4% were Hispanic, and 7.3% were of another race or ethnicity. Mental disorder was based on self-reported previous mental health treatment for particular mental disorders. Sexual victimization was measured by using questions adapted from the National Violence Against Women and Men surveys.Results: Approximately one in 12 male inmates with a mental disorder reported at least one incident of sexual victimization by another inmate over a six-month period, compared with one in 33 male inmates without a mental disorder. Among those with a mental disorder, sexual victimization was three times as high among female inmates (23.4%) as among male inmates (8.3%). African-American and Hispanic inmates with a mental disorder, independent of gender, reported higher rates of sexual victimization than their non-Hispanic white counterparts.Conclusions: Prisons are hazardous places. Steps must be taken to protect inmates from predators inside prison, to screen them for posttraumatic stress disorder, to provide trauma-related treatment, and to keep them safe.
SN - 1075-2730
AD - Center for Mental Health Services and Criminal Justice Research, 30 College Avenue, Rutgers University, New Brunswick, NJ 08901, USA
AD - Center for Mental Health Services and Criminal Justice Research, 30 College Ave., Rutgers University, New Brunswick, NJ 08901. nwolff@ifh.rutgers.edu.
U2 - PMID: 17664520.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105923982&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Atenstaedt, R. L.
T1 - The response to the trench diseases in World War I: A triumph of public health science.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2007/08//
VL - 121
IS - 8
M3 - Article
SP - 634
EP - 639
SN - 00333506
AB - The recent 90-year anniversary of the Battle of the Somme presents an opportunity to examine the public health response to the trench diseases, new conditions which arose in the trenches of World War I. Throughout history, there have been two views of epidemic disease: the configurationist and contagionist perspectives. Most doctors responding to the trench diseases, 'contingent-contagionists', combined these two conceptions of disease. Because of the difficulty of finding a causative organism and the absence of effective treatment, the majority view became that these conditions were a product of the trench environment. Configurationism, with its emphasis on environmental and social determinants, seemed to provide the most obvious approaches for tackling the trench diseases. The diseases were effectively controlled using the tools of public health science: sanitary discipline and a battery of measures, such as improving trench construction, improving the diet, providing protective kit, regular bathing and treating lice infestation. The response demonstrates the triumph of public health science over new medical technologies. It also illustrates the importance of considering all the many determinants of health and of close surveillance, discipline and partnership working to counter ill-health. Although technology, training, doctrine and health beliefs change over time, the interaction between disease and environment remains the core challenge to public health practitioners. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health (Elsevier) is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - EPIDEMICS
KW - SOMME, 1st Battle of the, France, 1916
KW - MEDICAL technology
KW - ENVIRONMENTALLY induced diseases
KW - MEDICAL personnel
KW - FRANCE
KW - Military personnel
KW - Nephritis
KW - Public health
KW - Trench fever
KW - Trench foot
KW - World War I
N1 - Accession Number: 26093186; Atenstaedt, R. L. 1; Email Address: Robert.Atenstaedt@nphs.wales.nhs.uk; Affiliation: 1: National Public Health Service for Wales and Institute of Medical & Social Care Research (IMSCaR), University of Wales, Bangor, Gwynedd LL57 2PX, UK; Source Info: Aug2007, Vol. 121 Issue 8, p634; Subject Term: PUBLIC health; Subject Term: EPIDEMICS; Subject Term: SOMME, 1st Battle of the, France, 1916; Subject Term: MEDICAL technology; Subject Term: ENVIRONMENTALLY induced diseases; Subject Term: MEDICAL personnel; Subject Term: FRANCE; Author-Supplied Keyword: Military personnel; Author-Supplied Keyword: Nephritis; Author-Supplied Keyword: Public health; Author-Supplied Keyword: Trench fever; Author-Supplied Keyword: Trench foot; Author-Supplied Keyword: World War I; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.puhe.2006.12.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 104746655
T1 - The response to the trench diseases in World War I: a triumph of public health science.
AU - Atenstaedt, R L
Y1 - 2007/08//
N1 - Accession Number: 104746655. Language: English. Entry Date: 20110610. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 0376507.
KW - Foot Diseases -- History
KW - Nephritis -- History
KW - Public Health -- History
KW - Gram-Negative Bacterial Infections -- History
KW - War
KW - Causal Attribution
KW - Disease Outbreaks -- History
KW - History
KW - Foot Diseases -- Drug Therapy
KW - Military Personnel -- History
KW - Nephritis -- Epidemiology
KW - Public Health -- Methods
KW - Gram-Negative Bacterial Infections -- Epidemiology
SP - 634
EP - 639
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 121
IS - 8
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service for Wales and Institute of Medical & Social Care Research (IMSCaR), University of Wales, Bangor, Gwynedd LL57 2PX, UK. Robert.Atenstaedt@nphs.wales.nhs.uk
U2 - PMID: 17540420.
DO - 10.1016/j.puhe.2006.12.014
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105994736
T1 - A comparison of fatigue failure responses of old versus middle-aged lumbar motion segments in simulated flexed lifting.
AU - Gallagher S
AU - Marras WS
AU - Litsky AS
AU - Burr D
AU - Landoll J
AU - Matkovic V
Y1 - 2007/08//
N1 - Accession Number: 105994736. Language: English. Entry Date: 20080222. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Physical Therapy. NLM UID: 7610646.
KW - Aging
KW - Bone Density
KW - Lifting
KW - Lumbar Vertebrae -- Physiopathology
KW - Movement
KW - Sacrum -- Physiopathology
KW - Spinal Fractures -- Physiopathology
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Cadaver
KW - Cox Proportional Hazards Model
KW - Female
KW - Kaplan-Meier Estimator
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Range of Motion
KW - Risk Assessment
KW - Risk Factors
KW - Spinal Fractures -- Etiology
KW - Time Factors
KW - Weight-Bearing
KW - Human
SP - 1832
EP - 1839
JO - Spine (03622436)
JF - Spine (03622436)
JA - SPINE
VL - 32
IS - 17
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Study Design. Survival analysis techniques were used to compare the fatigue failure responses of elderly motion segments to a middle-aged sample.Objectives. To compare fatigue life of a middle-aged sample of Iumbosacral motion segments to a previously tested elderly cohort. An additional objective was to evaluate the influence of bone mineral content on cycles to failure.Summary of Background Data. A previous investigation evaluated fatigue failure responses of 36 elderly Iumbosacral motion segments (average age, 81 ± 8 years) subjected to spinal loads estimated when lifting a 9-kg load in 3 torso flexion angles (0°, 22.5°, and 45°). Results demonstrated rapid fatigue failure with increased torso flexion; however, a key limitation of this study was the old age of the specimens.Methods. Each Iumbosacral spine was dissected into 3 motion segments (L1-L2, L3-L4, and L5-S1). Motion segments within each spine were randomly assigned to a spinal loading condition corresponding to lifting 9 kg in 3 torso flexion angles (0°, 22.5°, or 451. Motion segments were statically loaded and allowed to creep for 15 minutes, then cyclically loaded at 0.33 Hz. Fatigue life was taken as the number of cycles to failure (10 mm displacement after creep loading).Results. Compared with the older sample of spines, the middle-aged sample exhibited increased fatigue life (cycles to failure) in all the torso flexion conditions. In-creased fatigue life of the middle-aged specimens was associated with the increased bone mineral content (BM) in younger motion segments (mean ± SD, 30.7 ± 11.1 g per motion segment vs. 27.8 ± 9.4 g). Increasing bone mineral content had a protective influence with each additional gram increasing survival times by approximately 12%.Conclusion. Younger motion segments survive considerably longer when exposed to similar spine loading conditions that simulate repetitive lifting in neutral and flexed torso postures, primarily associated with the in-creased bone mineral content possessed by younger motion segments. Cycles to failure of young specimens at 22.5° flexion were similar to that of older specimens at 0° flexion, and survivorship of young specimens at 45° flexion was similar to the older cohort at 22.5°.
SN - 0362-2436
AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, Pittsburgh, PA 15236-0070; sgallagher@cdc.gov
U2 - PMID: 17762290.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Piper, John T.
AU - Gelderman, Monique P.
AU - Vostal, Jaroslav G.
T1 - In vivo recovery of human platelets in severe combined immunodeficient mice as a measure of platelet damage.
JO - Transfusion
JF - Transfusion
Y1 - 2007/08//
VL - 47
IS - 8
M3 - Article
SP - 1540
EP - 1549
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Clinical performance of human platelet (PLT) products processed or stored under novel conditions is difficult to predict based on in vitro studies alone. Recovery and survival of radiolabeled PLTs in human subjects are used as surrogate markers for PLT efficacy in development of new products. Such experiments pose some risk to the participants, can be a financial burden on the sponsor, and may stifle innovation and development of new PLT products. Animal models for in vivo recovery and survival of human PLTs are limited by rapid, immune-mediated clearance of human cells. The severe combined immunodeficient (SCID) mice allowed prolonged circulation of human PLTs and were used to detect differences in recovery and survival between chemically damaged, aged PLTs, or normal PLTs. STUDY DESIGN AND METHODS: Human PLTs were transfused into SCID and wild-type (WT) mice, and the recoveries and survival times were detected in mouse whole blood by flow cytometry with an anti-human CD41–fluorescein isothiocyanate monoclonal antibody. Recoveries of damaged PLTs were compared to normal PLTs. RESULTS: Recoveries were significantly shorter in WT than in SCID mice at 4 hours after transfusion (WT, 20.8 ± 5.4%, n = 12; SCID, 63.8 ± 8.4%, n = 10) and with a t½ estimate of 2 hours for WT and 7 hours for SCID mice. Human PLTs damaged either by chemical treatment or by improper storage exhibited decreased recoveries in SCID mice. CONCLUSION: The SCID mouse model can detect differences between damaged and control human PLTs and could be useful in evaluating novel PLT collection, processing, and storage technologies that may impact PLT quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelets
KW - MONOCLONAL antibodies
KW - BLOOD transfusion
KW - CELLS
KW - CYTOMETRY
N1 - Accession Number: 25847914; Piper, John T. 1 Gelderman, Monique P. 1 Vostal, Jaroslav G. 1; Email Address: vostal@cber.fda.gov; Affiliation: 1: Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, HFM-335, Rockville, MD 20852; Source Info: Aug2007, Vol. 47 Issue 8, p1540; Subject Term: BLOOD platelets; Subject Term: MONOCLONAL antibodies; Subject Term: BLOOD transfusion; Subject Term: CELLS; Subject Term: CYTOMETRY; Number of Pages: 10p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1537-2995.2007.01295.x
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Kohl, Katrin S.
AU - Gidudu, Jane
AU - Bonhoeffer, Jan
AU - Braun, M. Miles
AU - Buettcher, Michael
AU - Chen, Robert T.
AU - Drammeh, Bakary
AU - Duclos, Philippe
AU - Heijbel, Harald
AU - Heininger, Ulrich
AU - Hummelman, Erik
AU - Jefferson, Thomas
AU - Keller-Stanislawski, Brigitte
AU - Loupi, Elisabeth
AU - Marcy, S. Michael
T1 - The development of standardized case definitions and guidelines for adverse events following immunization
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Editorial
SP - 5671
EP - 5674
SN - 0264410X
N1 - Accession Number: 25750816; Kohl, Katrin S.; Email Address: kkohl@cdc.gov; Gidudu, Jane; Bonhoeffer, Jan 1; Braun, M. Miles 2; Buettcher, Michael 1; Chen, Robert T. 3; Drammeh, Bakary; Duclos, Philippe 4; Heijbel, Harald 5; Heininger, Ulrich 1; Hummelman, Erik 3; Jefferson, Thomas 6; Keller-Stanislawski, Brigitte 7; Loupi, Elisabeth 8; Marcy, S. Michael 9; Affiliations: 1: University Children's Hospital, Basel, Switzerland; 2: Food and Drug Administration, Rockville, MD, USA; 3: Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: World Health Organization, Geneva, Switzerland; 5: Swedish Institute of Infectious Diseases Control, Lund, Sweden; 6: Cochrane Vaccines Field, Rome, Italy; 7: Paul Ehrlich Institut, Langen, Germany; 8: Sanofi Pasteur, Lyon, France; 9: University of California Los Angeles (UCLA), Center for Vaccine Research, Kaiser Foundation Hospital, Panorama City, CA, USA; Issue Info: Aug2007, Vol. 25 Issue 31, p5671; Number of Pages: 4p; Document Type: Editorial
L3 - 10.1016/j.vaccine.2007.02.063
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Beigel, John
AU - Kohl, Katrin S.
AU - Khuri-Bulos, Najwa
AU - Bravo, Lulu
AU - Nell, Patricia
AU - Marcy, S. Michael
AU - Warschaw, Karen
AU - Ong-Lim, Anna
AU - Poerschke, Gabriele
AU - Weston, William
AU - Lindstrom, Jill A.
AU - Stoltman, Gillian
AU - Maurer, Toby
T1 - Rash including mucosal involvement: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5697
EP - 5706
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Mucocutaneous
KW - Rash
N1 - Accession Number: 25750819; Beigel, John 1; Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org; Khuri-Bulos, Najwa 3; Bravo, Lulu 4; Nell, Patricia 5; Marcy, S. Michael 6; Warschaw, Karen 7; Ong-Lim, Anna 4; Poerschke, Gabriele 8; Weston, William 9; Lindstrom, Jill A. 10; Stoltman, Gillian 11; Maurer, Toby 12; Affiliations: 1: National Institute of Health, Bethesda, MD, USA; 2: Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Jordan University Hospital, Amman, Jordan; 4: University of the Philippines, Manila, Philippines; 5: United States Air Force, Sturgeon Bay, WI, USA; 6: University of Southern California and University of California Los Angeles Schools of Medicine, Kaiser Foundation Hospital, Panorama City, CA, USA; 7: Mayo Clinic, Scottsdale, AZ, USA; 8: Merck, Sharp & Dohme (Asia) Ltd., Hong Kong, Hong Kong; 9: University of Colorado, Aurora, CO, USA; 10: Food and Drug Administration, Rockville, MD, USA; 11: Michigan Department of Community Health, Lansing, MI, USA; 12: University of California, San Francisco, CA, USA; Issue Info: Aug2007, Vol. 25 Issue 31, p5697; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Mucocutaneous; Author-Supplied Keyword: Rash; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jorch, Gerhard
AU - Tapiainen, Terhi
AU - Bonhoeffer, Jan
AU - Fischer, Thea K.
AU - Heininger, Ulrich
AU - Hoet, Bernard
AU - Kohl, Katrin S.
AU - Lewis, E.M.
AU - Meyer, Christiane
AU - Nelson, Tony
AU - Sandbu, Synne
AU - Schlaud, Martin
AU - Schwartz, Ann
AU - Varricchio, Frederick
AU - Wise, Robert P.
T1 - Unexplained sudden death, including sudden infant death syndrome (SIDS), in the first and second years of life: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5707
EP - 5716
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Sudden infant death syndrome
KW - Unexpected sudden death
KW - Unexplained sudden death
N1 - Accession Number: 25750820; Jorch, Gerhard 1; Tapiainen, Terhi 2,3; Bonhoeffer, Jan 2; Email Address: secretariat@brightoncollaboration.org; Fischer, Thea K. 4; Heininger, Ulrich 2; Hoet, Bernard 5; Kohl, Katrin S. 4; Lewis, E.M. 6; Meyer, Christiane 7; Nelson, Tony 8; Sandbu, Synne 9; Schlaud, Martin 7; Schwartz, Ann 10; Varricchio, Frederick 10; Wise, Robert P. 10; Affiliations: 1: University of Magdeburg, Magdeburg, Germany; 2: University Children's Hospital, Basel, Switzerland; 3: University of Oulu, Oulu, Finland; 4: Centers for Disease Control and Prevention, Atlanta, GA, USA; 5: GlaxoSmithKline Biologicals, Rixensart, Belgium; 6: Kaiser Permanente, of Northern California, Oakland, CA, USA; 7: Robert Koch Institute, Berlin, Germany; 8: Chinese University of Hong Kong, and Prince of Wales Hospital, Hong Kong; 9: Institute of Public Health, Oslo, Norway; 10: Food and Drug Administration, Rockville, MD, USA; Issue Info: Aug2007, Vol. 25 Issue 31, p5707; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Sudden infant death syndrome; Author-Supplied Keyword: Unexpected sudden death; Author-Supplied Keyword: Unexplained sudden death; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wise, Robert P.
AU - Bonhoeffer, Jan
AU - Beeler, Judy
AU - Donato, Hugo
AU - Downie, Peter
AU - Matthews, Dana
AU - Pool, Vitali
AU - Riise-Bergsaker, Marianne
AU - Tapiainen, Terhi
AU - Varricchio, Frederick
T1 - Thrombocytopenia: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5717
EP - 5724
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Thrombocytopenia
N1 - Accession Number: 25750821; Wise, Robert P. 1; Bonhoeffer, Jan 2; Email Address: secretariat@brightoncollaboration.org; Beeler, Judy 1; Donato, Hugo 3; Downie, Peter 4; Matthews, Dana 5; Pool, Vitali 6; Riise-Bergsaker, Marianne 7; Tapiainen, Terhi 2,8; Varricchio, Frederick 1; Affiliations: 1: Food and Drug Administration, Rockville, MD, USA; 2: University Children's Hospital, Basel, Switzerland; 3: Hospital del Niño, San Justo, Buenos Aires, Argentina; 4: Royal Children's Hospital, Melbourne, Australia; 5: University of Washington and Children's Hospital and Regional Medical Center, Seattle, WA, USA; 6: Centers for Disease Control and Prevention, Atlanta, GA, USA; 7: Norwegian Institute of Public Health, Oslo, Norway; 8: University of Oulu, Oulu, Finland; Issue Info: Aug2007, Vol. 25 Issue 31, p5717; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Thrombocytopenia; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nell, Patricia
AU - Kohl, Katrin S.
AU - Graham, Philip L.
AU - LaRussa, Philip S.
AU - Marcy, S. Michael
AU - Fulginiti, Vincent A.
AU - Martin, Bryan
AU - McMahon, Ann
AU - Norton, Scott A.
AU - Trolin, Ingrid
T1 - Progressive vaccinia as an adverse event following exposure to vaccinia virus: Case definition and guidelines of data collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5735
EP - 5744
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Progressive vaccinia
KW - Smallpox vaccine
KW - Vaccinia virus
N1 - Accession Number: 25750823; Nell, Patricia 1; Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org; Graham, Philip L. 3; LaRussa, Philip S. 4; Marcy, S. Michael 5; Fulginiti, Vincent A. 6; Martin, Bryan 7; McMahon, Ann 8; Norton, Scott A. 9; Trolin, Ingrid 10; Affiliations: 1: Airforce Reserve Command, United States Air Force, Sturgeon Bay, WI, USA; 2: Immunization Safety Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Department of Pediatrics, College of Physicians & Surgeons, Columbia University, Department of Epidemiology, New York Presbyterian Hospital, New York, NY, USA; 4: Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA; 5: University of Southern California and University of California Los Angeles Schools of Medicine; Kaiser Foundation Hospital, Panorama City, CA, USA; 6: Department of Pediatrics, University of Arizona Tucson, AZ and University of Colorado, Denver, CO, USA; 7: Department of Allergy and Immunology, Walter Reed Army Hospital, Washington, DC, USA; 8: Vaccine Safety Branch, Food and Drug Administration, Rockville, MD, USA; 9: Walter Reed Army Medical Center, Washington, DC, USA; 10: Medical Product Agency, Uppsala, Sweden; Issue Info: Aug2007, Vol. 25 Issue 31, p5735; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Progressive vaccinia; Author-Supplied Keyword: Smallpox vaccine; Author-Supplied Keyword: Vaccinia virus; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.02.088
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sejvar, James J.
AU - Kohl, Katrin S.
AU - Bilynsky, Roman
AU - Blumberg, Dean
AU - Cvetkovich, Therese
AU - Galama, Jochem
AU - Gidudu, Jane
AU - Katikaneni, Lakshmi
AU - Khuri-Bulos, Najwa
AU - Oleske, James
AU - Tapiainen, Terhi
AU - Wiznitzer, Max
T1 - Encephalitis, myelitis, and acute disseminated encephalomyelitis (ADEM): Case definitions and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5771
EP - 5792
SN - 0264410X
KW - ADEM
KW - Adverse event
KW - Case definition
KW - Encephalitis
KW - Encephalomyelitis
KW - Guidelines
KW - Immunization
KW - Myelitis
N1 - Accession Number: 25750827; Sejvar, James J. 1; Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org; Bilynsky, Roman 3; Blumberg, Dean 4; Cvetkovich, Therese 5; Galama, Jochem 6; Gidudu, Jane 2; Katikaneni, Lakshmi 7; Khuri-Bulos, Najwa 8; Oleske, James 9; Tapiainen, Terhi 10,11; Wiznitzer, Max 12; Affiliations: 1: Division of Viral and Rickettsial Diseases and Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Immunization Safety Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Department of Pediatrics, Wake Forest University Medical School, Winston-Salem, NC, USA; 4: Department of Pediatrics, UC Davis Medical Center, Sacramento, CA, USA; 5: Division of Vaccines and Related Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; 6: Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, Netherlands; 7: Department of Pediatrics, University of South Carolina, Charleston, SC, USA; 8: Pediatric Infectious Diseases, Jordan University Hospital, Jordan; 9: Division of Pulmonary, Allergy, Immunology & Infectious Diseases, New Jersey Medical School, NJ, USA; 10: University Children's Hospital Basel, Switzerland; 11: Department of Pediatrics, University of Oulu, Finland; 12: Department of Neurology, University Hospitals of Cleveland, Cleveland, OH, USA; Issue Info: Aug2007, Vol. 25 Issue 31, p5771; Author-Supplied Keyword: ADEM; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Encephalitis; Author-Supplied Keyword: Encephalomyelitis; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Myelitis; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.060
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tapiainen, Terhi
AU - Prevots, Rebecca
AU - Izurieta, Hector S.
AU - Abramson, Jon
AU - Bilynsky, Roman
AU - Bonhoeffer, Jan
AU - Bonnet, Marie-Claude
AU - Center, Kimberly
AU - Galama, Jochem
AU - Gillard, Paul
AU - Griot, Monika
AU - Hartmann, Katharina
AU - Heininger, Ulrich
AU - Hudson, Michael
AU - Koller, Annette
AU - Khetsuriani, Nino
AU - Khuri-Bulos, Najwa
AU - Marcy, S. Michael
AU - Matulionyte, Raimonda
AU - Schöndorf, Ines
T1 - Aseptic meningitis: Case definition and guidelines for collection, analysis and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5793
EP - 5802
SN - 0264410X
KW - Adverse event
KW - adverse event following immunization ( AEFI )
KW - Aseptic meningitis
KW - C-reactive protein ( CRP )
KW - Case definition
KW - central nervous system ( CNS )
KW - cerebrospinal fluid ( CSF )
KW - Guidelines
KW - Immunization
KW - lumbar puncture ( LP )
KW - measles–mumps–rubella (vaccine) ( MMR )
KW - polymerase chain reaction ( PCR )
KW - red blood cell ( RBC )
KW - restriction fragment-length polymorphism ( RFLP )
KW - white blood cell ( WBC )
N1 - Accession Number: 25750828; Tapiainen, Terhi 1,2; Prevots, Rebecca 3; Izurieta, Hector S. 4; Abramson, Jon 5; Bilynsky, Roman 6; Bonhoeffer, Jan 1; Email Address: secretariat@brightoncollaboration.org; Bonnet, Marie-Claude 7; Center, Kimberly 8; Galama, Jochem 9; Gillard, Paul 10; Griot, Monika 11; Hartmann, Katharina 11; Heininger, Ulrich 1; Hudson, Michael 12; Koller, Annette 11; Khetsuriani, Nino 13; Khuri-Bulos, Najwa 14; Marcy, S. Michael 15; Matulionyte, Raimonda 16; Schöndorf, Ines 17; Affiliations: 1: University Children's Hospital, Basel, Switzerland; 2: Department of Pediatrics, University of Oulu, Finland; 3: National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; 5: Department of Pediatrics, Wake Forest University Medical School, Winston-Salem, NC, USA; 6: Patterson Army Health Center, Fort Monmouth, NJ, USA; 7: Aventis Pasteur, Lyon, France; 8: Wyeth Pharmaceuticals, Collegeville, PA, USA; 9: Department of Medical Microbiology, University Medical Center, Nijmegen, The Netherlands; 10: Glaxo Smith Kline, Rixensart, Belgium; 11: Berna Biotech, Kusnacht, Switzerland; 12: Health Protection Agency, Centre for Emergency Preparedness and Response, Salisbury, United Kingdom; 13: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; 14: Pediatric Infectious Diseases, Jordan University Hospital, Jordan; 15: University of Southern California and University of California Los Angeles Schools of Medicine, Kaiser Foundation Hospital, Panorama City, CA, USA; 16: Department of Infectious Diseases, Vilnius University, Lithuania; 17: Novartis Vaccines, Marburg, Germany; Issue Info: Aug2007, Vol. 25 Issue 31, p5793; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: adverse event following immunization ( AEFI ); Author-Supplied Keyword: Aseptic meningitis; Author-Supplied Keyword: C-reactive protein ( CRP ); Author-Supplied Keyword: Case definition; Author-Supplied Keyword: central nervous system ( CNS ); Author-Supplied Keyword: cerebrospinal fluid ( CSF ); Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: lumbar puncture ( LP ); Author-Supplied Keyword: measles–mumps–rubella (vaccine) ( MMR ); Author-Supplied Keyword: polymerase chain reaction ( PCR ); Author-Supplied Keyword: red blood cell ( RBC ); Author-Supplied Keyword: restriction fragment-length polymorphism ( RFLP ); Author-Supplied Keyword: white blood cell ( WBC ); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.058
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Halperin, Scott
AU - Kohl, Katrin S.
AU - Gidudu, Jane
AU - Ball, Leslie
AU - Hammer, Sandra Jo
AU - Heath, Paul
AU - Hennig, Renald
AU - Labadie, Jerry
AU - Rothstein, Edward
AU - Schuind, Anne
AU - Varricchio, Frederick
AU - Walop, Wikke
T1 - Cellulitis at injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5803
EP - 5820
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Cellulitis
KW - Guidelines
KW - Immunization
N1 - Accession Number: 25750829; Halperin, Scott 1; Kohl, Katrin S. 2; Email Address: secretariat@brightoncollaboration.org; Gidudu, Jane 2; Ball, Leslie 3; Hammer, Sandra Jo 4; Heath, Paul 5; Hennig, Renald 6; Labadie, Jerry 7; Rothstein, Edward 8; Schuind, Anne 9; Varricchio, Frederick 3; Walop, Wikke 10; Affiliations: 1: Dalhousie University, Halifax, Nova Scotia, Canada; 2: Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Food and Drug Administration, Rockville, MD, USA; 4: California Department of Public Health, Richmond, CA, USA; 5: St. George's Hospital Medical School, London, UK; 6: Novartis Vaccine, Marburg, Germany; 7: Netherlands Pharmacovigilance Centre Lareb’, S-Hertogenbosch, the Netherlands; 8: Pennridge Pediatric Associates, Sellersville, PA, USA; 9: GlaxoSmithKline, King of Prussia, PA, USA; 10: Public Health Agency of Canada, Ottawa, Ontario, Canada; Issue Info: Aug2007, Vol. 25 Issue 31, p5803; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Cellulitis; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.059
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kohl, Katrin S.
AU - Ball, Leslie
AU - Gidudu, Jane
AU - Hammer, Sandra Jo
AU - Halperin, Scott
AU - Heath, Paul
AU - Hennig, Renald
AU - Labadie, Jerry
AU - Rothstein, Edward
AU - Schuind, Anne
AU - Varricchio, Frederick
AU - Walop, Wikke
T1 - Abscess at injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5821
EP - 5838
SN - 0264410X
KW - Abscess
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
N1 - Accession Number: 25750830; Kohl, Katrin S. 1; Email Address: secretariat@brightoncollaboration.org; Ball, Leslie 2; Gidudu, Jane 1; Hammer, Sandra Jo 3; Halperin, Scott 4; Heath, Paul 5; Hennig, Renald 6; Labadie, Jerry 7; Rothstein, Edward 8; Schuind, Anne 9; Varricchio, Frederick 2; Walop, Wikke 10; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Food and Drug Administration, Rockville, MD, USA; 3: California Department of Public Health, Richmond, CA, USA; 4: Dalhousie University, Halifax, Nova Scotia, Canada; 5: St. George's Hospital Medical School, London, UK; 6: Novartis Vaccine, Marburg, Germany; 7: Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands; 8: Pennridge Pediatric Associates, Sellersville, PA, USA; 9: GlaxoSmithKline, King of Prussia, PA, USA; 10: Public Health Agency of Canada, Ottawa, Ontario, Canada; Issue Info: Aug2007, Vol. 25 Issue 31, p5821; Author-Supplied Keyword: Abscess; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25750830&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kohl, Katrin S.
AU - Walop, Wikke
AU - Gidudu, Jane
AU - Ball, Leslie
AU - Halperin, Scott
AU - Hammer, Sandra Jo
AU - Heath, Paul
AU - Hennig, Renald
AU - Rothstein, Edward
AU - Schuind, Anne
AU - Varricchio, Frederick
T1 - Induration at or near injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5839
EP - 5857
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Induration
N1 - Accession Number: 25750831; Kohl, Katrin S. 1; Email Address: secretariat@brightoncollaboration.org; Walop, Wikke 2; Gidudu, Jane 1; Ball, Leslie 3; Halperin, Scott 4; Hammer, Sandra Jo 5; Heath, Paul 6; Hennig, Renald 7; Rothstein, Edward 8; Schuind, Anne 9; Varricchio, Frederick 3; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Public Health Agency of Canada, Ottawa, Ontario, Canada; 3: Food and Drug Administration, Rockville, MD, USA; 4: Dalhousie University, Halifax, Nova Scotia, Canada; 5: California Department of Public Health, Richmond, CA, USA; 6: St. George's Hospital Medical School, London, UK; 7: Novartis Vaccine, Marburg, Germany; 8: Pennridge Pediatric Associates, Sellersville, PA, USA; 9: GlaxoSmithKline, King of Prussia, PA, USA; Issue Info: Aug2007, Vol. 25 Issue 31, p5839; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Induration; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.062
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25750831&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kohl, Katrin S.
AU - Walop, Wikke
AU - Gidudu, Jane
AU - Ball, Leslie
AU - Halperin, Scott
AU - Hammer, Sandra Jo
AU - Heath, Paul
AU - Varricchio, Frederick
AU - Rothstein, Edward
AU - Schuind, Anne
AU - Hennig, Renald
T1 - Swelling at or near injection site: Case definition and guidelines for collection, analysis and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5858
EP - 5874
SN - 0264410X
KW - Adverse event
KW - Case definition
KW - Guidelines
KW - Immunization
KW - Swelling
N1 - Accession Number: 25750832; Kohl, Katrin S. 1; Email Address: secretariat@brightoncollaboration.org; Walop, Wikke 2; Gidudu, Jane 1; Ball, Leslie 3; Halperin, Scott 4; Hammer, Sandra Jo 5; Heath, Paul 6; Varricchio, Frederick 3; Rothstein, Edward 7; Schuind, Anne 8; Hennig, Renald 9; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Public Health Agency of Canada, Ottawa, Ont., Canada; 3: Food and Drug Administration, Rockville, MD, USA; 4: Dalhousie University, Halifax, NS, Canada; 5: California Department of Public Health, Richmond, CA, USA; 6: St. George's Hospital Medical School, London, UK; 7: Pennridge Pediatric Associates, Sellersville, PA, USA; 8: GlaxoSmithKline, King of Prussia, PA, USA; 9: Novartis Vaccine, Marburg, Germany; Issue Info: Aug2007, Vol. 25 Issue 31, p5858; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Swelling; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.056
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25750832&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buettcher, Michael
AU - Heininger, Ulrich
AU - Braun, Miles
AU - Bonhoeffer, Jan
AU - Halperin, Scott
AU - Heijbel, Harald
AU - de Menezes Martins, Reinaldo
AU - Vermeer-de Bondt, Patricia
T1 - Hypotonic-hyporesponsive episode (HHE) as an adverse event following immunization in early childhood: Case definition and guidelines for data collection, analysis, and presentation
JO - Vaccine
JF - Vaccine
Y1 - 2007/08//
VL - 25
IS - 31
M3 - Article
SP - 5875
EP - 5881
SN - 0264410X
KW - Adverse event
KW - adverse event following immunization ( AEFI )
KW - Case definition
KW - diphtheria-tetanus-whole cell pertussis component vaccine ( DTPw )
KW - Guidelines
KW - Hypotonic-hyporesponsive episode
KW - hypotonic-hyporesponsive episode ( HHE )
KW - Immunization
N1 - Accession Number: 25750833; Buettcher, Michael 1; Heininger, Ulrich 1; Email Address: ulrich.heininger@ukbb.ch; Braun, Miles 2; Bonhoeffer, Jan 1; Halperin, Scott 3; Heijbel, Harald 4; de Menezes Martins, Reinaldo 5; Vermeer-de Bondt, Patricia 6; Affiliations: 1: University Children's Hospital, Basel, Switzerland; 2: Food and Drug Administration, Rockville, MD, USA; 3: Dalhousie University, Halifax, Nova Scotia, Canada; 4: Swedish Institute of Infectious Disease Control, Lund, Sweden; 5: Bio-Manguinhos Fiocruz, Brazil; 6: National Institute for Public Health and Environment, Bilthoven, The Netherlands; Issue Info: Aug2007, Vol. 25 Issue 31, p5875; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: adverse event following immunization ( AEFI ); Author-Supplied Keyword: Case definition; Author-Supplied Keyword: diphtheria-tetanus-whole cell pertussis component vaccine ( DTPw ); Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Hypotonic-hyporesponsive episode; Author-Supplied Keyword: hypotonic-hyporesponsive episode ( HHE ); Author-Supplied Keyword: Immunization; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.04.061
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25750833&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2007-13877-001
AN - 2007-13877-001
AU - Hopson, Deborah Parham
AU - Morgan, Douglas H.
AU - Gray, Sonya Hunt
AU - Conviser, Richard
T1 - CARE Act planning for unmet need.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 1
EP - 7
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Hopson, Deborah Parham
N1 - Accession Number: 2007-13877-001. Partial author list: First Author & Affiliation: Hopson, Deborah Parham; HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; Health Care Delivery; Health Service Needs; HIV; Needs Assessment. Minor Descriptor: Government Programs; Primary Health Care; Program Development; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 7. Issue Publication Date: Aug, 2007.
AB - The Ryan White CARE Act, a safety net program first enacted in 1990, provides health and support services to people living with HIV (PLWH) in the U.S. through several Titles. Recipients of CARE Act funds--particularly metropolitan areas and States under Titles I and II, respectively--prioritize and allocate funds to cover unmet service needs. In the 2000 reauthorization of the CARE Act, Title I and II grantees were directed to determine unmet needs for services. This paper describes a process by which the HIV/AIDS Bureau of the Health Resources and Services Administration of the U.S. Department of Health and Human Services has assisted grantees in developing tools to make quantitative estimates of the unmet need for HIV primary care services. The process enables grantees to identify underserved populations and implement strategies to bring them into regular primary care. The Care System Assessment Demonstration Project supplements these tools. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - CARE Act planning
KW - unmet needs
KW - HIV
KW - AIDS
KW - primary care services
KW - 2007
KW - AIDS
KW - Health Care Delivery
KW - Health Service Needs
KW - HIV
KW - Needs Assessment
KW - Government Programs
KW - Primary Health Care
KW - Program Development
KW - Health Care Policy
KW - 2007
DO - 10.1353/hpu.2007.0082
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-001&site=ehost-live&scope=site
UR - conviser@alumni.reed.edu
UR - SGray@hrsa.gov
UR - DMorgan@hrsa.gov
UR - DParham@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13877-002
AN - 2007-13877-002
AU - Conviser, Richard
AU - Pounds, Moses B.
T1 - Background--The origins of the Care System Assessment Demonstration Project.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 8
EP - 15
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Conviser, Richard
N1 - Accession Number: 2007-13877-002. Partial author list: First Author & Affiliation: Conviser, Richard; Health Resources and Services Administraiton, HIV/AIDS Bureau, U.S. Department of Health and Human Services, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Service Needs; Minority Groups; Needs Assessment; Treatment Barriers. Minor Descriptor: Community Services; Government Programs; HIV; Health Care Administration. Classification: Health & Mental Health Services (3370). Population: Human (10). Page Count: 8. Issue Publication Date: Aug, 2007.
AB - The Care System Assessment Demonstration Project was designed to assist community planning bodies in determining barriers to care for people living with HIV (PLWH) in selected underserved minority populations and generating recommendations for care system enhancement that would lower those barriers. This paper describes the selection of three sites to participate in the project and sketches the two primary tools used in implementing the project: Rapid Assessment, Response and Evaluation (RARE) techniques initially developed to assess community HIV prevention needs, and a system assessment model created to help communities conduct systematic evaluations of their HIV care systems. The paper also provides an overview of the remaining chapters of the supplement, detailing how the project was implemented at the national level and the three participating sites and evaluating both the project's process and its local impact. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Care System Assessment Demonstration Project
KW - community planning bodies
KW - care barriers
KW - people living with HIV
KW - minority populations
KW - 2007
KW - Health Care Services
KW - Health Service Needs
KW - Minority Groups
KW - Needs Assessment
KW - Treatment Barriers
KW - Community Services
KW - Government Programs
KW - HIV
KW - Health Care Administration
KW - 2007
DO - 10.1353/hpu.2007.0078
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-002&site=ehost-live&scope=site
UR - MPounds@hrsa.gov
UR - conviser@alumni.reed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13877-003
AN - 2007-13877-003
AU - Bates, Christopher
AU - Singer, Merrill
AU - Trotter, Robert T. II
T1 - The RARE mode of rapid HIV risk assessment.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 16
EP - 33
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Bates, Christopher
N1 - Accession Number: 2007-13877-003. Partial author list: First Author & Affiliation: Bates, Christopher; Office of HIV/AIDS Policy, U.S. Department of Health and Human Services, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; At Risk Populations; HIV; Qualitative Research; Risk Assessment. Minor Descriptor: AIDS Prevention; HIV Testing. Classification: Promotion & Maintenance of Health & Wellness (3365); Research Methods & Experimental Design (2260). Population: Human (10). Location: US. Page Count: 18. Issue Publication Date: Aug, 2007.
AB - The impact of the HIV/AIDS epidemic on minority communities called for interventions to stem the increase in new HIV infections and identify HIV-positive individuals for referral to care and treatment services. The Rapid Assessment, Response and Evaluation (RARE) project was designed to provide highly affected communities with a tool that would quickly identify conditions that fuel new infections and serve as barriers to HIV-positive individuals getting HIV testing, care, and treatment. RARE brought indigenous community health outreach workers and key community-level stakeholders together to advocate for the transfer of findings into programmatic and policy responses in places where high risk behaviors were practiced. This article describes RARE's qualitative methods that captured the voice of those most affected by the HIV/AIDS threat and identified critical insights and dynamics about factors that lead to HIV infections and those that can move positive individuals into care and treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Rapid Assessment Response and Evaluation project
KW - AIDS
KW - HIV testing
KW - treatment barriers
KW - qualitative methods
KW - high risk behavior
KW - 2007
KW - AIDS
KW - At Risk Populations
KW - HIV
KW - Qualitative Research
KW - Risk Assessment
KW - AIDS Prevention
KW - HIV Testing
KW - 2007
DO - 10.1353/hpu.2007.0075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-003&site=ehost-live&scope=site
UR - robert.trotter@NAU.EDU
UR - anthro8566@aol.com
UR - Christopher.Bates@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06905-004
AN - 2008-06905-004
AU - Teresi, Jeanne A.
AU - Fleishman, John A.
T1 - Differential item functioning and health assessment.
JF - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JO - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JA - Qual Life Res
Y1 - 2007/08//
VL - 16
IS - Suppl1
SP - 33
EP - 42
CY - Germany
PB - Springer
SN - 0962-9343
SN - 1573-2649
AD - Teresi, Jeanne A., Research Division, Hebrew Home for the Aged at Riverdale, 5901 Palisade Avenue, Riverdale, NY, US, 10471
N1 - Accession Number: 2008-06905-004. Partial author list: First Author & Affiliation: Teresi, Jeanne A.; Research Division, Hebrew Home for the Aged at Riverdale, Riverdale, NY, US. Release Date: 20080609. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: National Institutes of Health Conference on Patient Reported Outcomes, Jun, 2004, Bethesda, MD, US. Conference Note: An earlier version of this paper was presented at the aforementioned conference. Major Descriptor: Health; Item Response Theory; Logistic Regression; Measurement. Classification: Statistics & Mathematics (2240); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: Aug, 2007.
AB - Establishing measurement equivalence is important because inaccurate assessment may lead to incorrect estimates of effects in research, and to suboptimal decisions at the individual, clinical level. Examination of differential item functioning (DIF) is a method for studying measurement equivalence. An item (i.e., one question in a longer scale) exhibits DIF if the item response differs across groups (e.g., gender, race), controlling for an estimate of the construct being measured. A distinction between applications in health, as contrasted with other settings such as educational and aptitude testing, is that there are many health-related constructs and multiple measures of each, few of which have received much critical evaluation. Discussed in this article are several methods for detection of differential item functioning (DIF), including non-parametric and parametric methods such as logistic regression, and those based on item response theory. Basic definitions and criteria for DIF detection are provided, as are steps in performing the analyses. Recommendations are presented and future directions discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - differential item functioning
KW - health assessment
KW - item response theory
KW - logistic regression
KW - 2007
KW - Health
KW - Item Response Theory
KW - Logistic Regression
KW - Measurement
KW - 2007
U1 - Sponsor: National Institute on Aging, US. Recipients: No recipient indicated
U1 - Sponsor: Columbia University, Resource Center for Minority Aging Research, US. Grant: AG15294. Recipients: No recipient indicated
U1 - Sponsor: National Cancer Institute, US. Other Details: Through the Veteran's Administration Measurement Excellence and Training Resource Information Center (METRIC). Recipients: No recipient indicated
DO - 10.1007/s11136-007-9184-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06905-004&site=ehost-live&scope=site
UR - Teresimeas@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13877-004
AN - 2007-13877-004
AU - Conviser, Richard
AU - Pounds, Moses B.
T1 - The Care System Assessment Model and its operationalization.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 34
EP - 51
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Conviser, Richard
N1 - Accession Number: 2007-13877-004. Partial author list: First Author & Affiliation: Conviser, Richard; Health Resources and Services Administration, HIV/AIDS Bureau, U.S. Department of Health and Human Services, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: HIV; Minority Groups; Models; Program Development; Program Evaluation. Minor Descriptor: Communities; Government Programs; Health Care Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 18. Issue Publication Date: Aug, 2007.
AB - The care system assessment model is intended to help community planning bodies for HIV services conduct systematic evaluations of existing care systems, with an eye toward changing them to make services more accessible to people living with HIV (PLWH) from underserved minority communities. The model has four structural and three cultural/behavioral dimensions. The structural dimensions are system comprehensiveness, capacity, integration, and accessibility; the cultural/behavioral dimensions are service acceptability, technical competencies (of both providers and potential system users), and client health-seeking behaviors. This chapter describes the model's dimensions and ways to operationalize them through document reviews and other methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - care system assessment model
KW - model operationalization
KW - community planning bodies
KW - HIV services
KW - people living with HIV
KW - minority communities
KW - 2007
KW - HIV
KW - Minority Groups
KW - Models
KW - Program Development
KW - Program Evaluation
KW - Communities
KW - Government Programs
KW - Health Care Services
KW - 2007
DO - 10.1353/hpu.2007.0079
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-004&site=ehost-live&scope=site
UR - MPounds@hrsa.gov
UR - conviser@alumni.reed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12288-003
AN - 2007-12288-003
AU - Bollen, Kenneth A.
AU - Kirby, James B.
AU - Curran, Patrick J.
AU - Paxton, Pamela M.
AU - Chen, Feinian
T1 - Latent variable models under misspecification: Two-stage least squares (2SLS) and maximum likelihood (ML) estimators.
JF - Sociological Methods & Research
JO - Sociological Methods & Research
JA - Sociol Methods Res
Y1 - 2007/08//
VL - 36
IS - 1
SP - 48
EP - 86
CY - US
PB - Sage Publications
SN - 0049-1241
SN - 1552-8294
AD - Bollen, Kenneth A., Department of Sociology, University of North Carolina, CB 3210 Hamilton, Chapel Hill, NC, US, 27599-3210
N1 - Accession Number: 2007-12288-003. Partial author list: First Author & Affiliation: Bollen, Kenneth A.; Odum Institute for Research in Social Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, US. Release Date: 20071119. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Research Methods 2003 Conference, Jun, 2003, Free University, Amsterdam, Netherlands. Grant Information: Bollen, Kenneth A. Conference Note: An earlier version of this article was presented at the aforementioned conference. Major Descriptor: Least Squares; Maximum Likelihood; Statistical Estimation; Structural Equation Modeling. Classification: Statistics & Mathematics (2240). Methodology: Quantitative Study. References Available: Y. Page Count: 39. Issue Publication Date: Aug, 2007.
AB - This article compares maximum likelihood (ML) estimation to three variants of two-stage least squares (2SLS) estimation in structural equation models. The authors use models that are both correctly and incorrectly specified. Simulated data are used to assess bias, efficiency, and accuracy of hypothesis tests. Generally, 2SLS with reduced sets of instrumental variables performs similarly to ML when models are correctly specified. Under correct specification, both estimators have little bias except at the smallest sample sizes and are approximately equally efficient. As predicted, when models are incorrectly specified, 2SLS generally performs better, with less bias and more accurate hypothesis tests. Unless a researcher has tremendous confidence in the correctness of his or her model, these results suggest that a 2SLS estimator should be considered. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - variable models
KW - two-stage least squares
KW - maximum likelihood estimators
KW - structural equation models
KW - 2007
KW - Least Squares
KW - Maximum Likelihood
KW - Statistical Estimation
KW - Structural Equation Modeling
KW - 2007
U1 - Sponsor: National Science Foundation. Grant: SES 0617276. Recipients: Bollen, Kenneth A.
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: 1-R01-DA13148-01; DA013148-05A2. Recipients: Bollen, Kenneth A.; Curran, Patrick J.
DO - 10.1177/0049124107301947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12288-003&site=ehost-live&scope=site
UR - bollen@unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13877-005
AN - 2007-13877-005
AU - Conviser, Richard
AU - Singer, Merrill
AU - Pounds, Moses B.
T1 - Adapting RARE to assess barriers to service receipt among people out of care.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 52
EP - 68
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Conviser, Richard
N1 - Accession Number: 2007-13877-005. Partial author list: First Author & Affiliation: Conviser, Richard; Health Resources and Services Administration, HIV/AIDS Bureau, U.S. Department of Health and Human Services, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; HIV; Needs Assessment; Treatment Planning; Treatment Barriers. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. Page Count: 17. Issue Publication Date: Aug, 2007.
AB - This paper describes the components of Rapid Assessment, Response and Evaluation (RARE), developed for HIV prevention planning; the adaptation of its methods to services planning; the venues in which the use of RARE was recommended for the present Care System Assessment Demonstration Project; constraints on what projects using RARE and the system assessment model may expect to accomplish; the focus of RARE questions for the project, concerning the characteristics of PLWH not in regular primary care, the care system as PLWH not in care perceive and experience it, and characteristics of the physical and social environments in which they live; how information from RARE can contribute to the enhancement of care systems; and the types of questions that sites could ask to gather RARE information for services planning. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Rapid Assessment
KW - Response and Evaluation
KW - service barriers
KW - service receipt
KW - HIV prevention planning
KW - services planning
KW - 2007
KW - AIDS Prevention
KW - HIV
KW - Needs Assessment
KW - Treatment Planning
KW - Treatment Barriers
KW - 2007
DO - 10.1353/hpu.2007.0119
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-005&site=ehost-live&scope=site
UR - MPounds@hrsa.gov
UR - anthro8566@aol.com
UR - conviser@alumni.reed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06905-015
AN - 2008-06905-015
AU - Reeve, Bryce B.
AU - Burke, Laurie B.
AU - Chiang, Yen-pin
AU - Clauser, Steven B.
AU - Colpe, Lisa J.
AU - Elias, Jeffrey W.
AU - Fleishman, John
AU - Hohmann, Ann A.
AU - Johnson-Taylor, Wendy L.
AU - Lawrence, William
AU - Moy, Claudia S.
AU - Quatrano, Louis A.
AU - Riley, William T.
AU - Smothers, Barbara A.
AU - Werner, Ellen M.
T1 - Enhancing measurement in health outcomes research supported by agencies within the US Department of Health and Human Services.
JF - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JO - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JA - Qual Life Res
Y1 - 2007/08//
VL - 16
IS - Suppl1
SP - 175
EP - 186
CY - Germany
PB - Springer
SN - 0962-9343
SN - 1573-2649
AD - Reeve, Bryce B., Outcomes Research Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, EPN 4005, 6130 Executive Blvd., MSC 7344, Bethesda, MD, US, 20892-7344
N1 - Accession Number: 2008-06905-015. Partial author list: First Author & Affiliation: Reeve, Bryce B.; Outcomes Research Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Maintenance Organizations; Quality of Life; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 12. Issue Publication Date: Aug, 2007.
AB - Many of the Institutes, Agencies and Centers that make up the US Department of Health and Human Services (DHHS) have recognized the need for better instrumentation in health outcomes research, and provide support, both internally and externally, for research utilizing advances in measurement theory and computer technology (informatics). In this paper, representatives from several DHHS agencies and institutes will discuss their need for better instruments within their discipline and describe current or future initiatives for exploring the benefits of these technologies. Together, the perspectives underscore the importance of developing valid, precise, and efficient measures to capture the full burden of disease and treatment on patients. Initiatives, like the Patient-Reported Outcomes Measurement Information System (PROMIS) to create health-related quality of life item banks, represent a trans-DHHS effort to develop a standard set of measures for informing decision making in clinical research, practice, and health policy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health outcomes research
KW - health care agencies
KW - US Department of Health and Human Services
KW - health related quality of life
KW - health care policy
KW - 2007
KW - Health
KW - Health Maintenance Organizations
KW - Quality of Life
KW - Health Care Policy
KW - 2007
DO - 10.1007/s11136-007-9190-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06905-015&site=ehost-live&scope=site
UR - reeveb@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13877-015
AN - 2007-13877-015
AU - Aranda-Naranjo, Barbara
T1 - The Care System Assessment Project: Values-based health care planning and delivery.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3,Suppl
SP - 244
EP - 247
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Aranda-Naranjo, Barbara
N1 - Accession Number: 2007-13877-015. Partial author list: First Author & Affiliation: Aranda-Naranjo, Barbara; Global HIV/AIDS Office, HRSA, HIV/AIDS Bureau, US. Release Date: 20080609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Health Service Needs; HIV; Social Values; Treatment Planning. Minor Descriptor: AIDS; Community Involvement; Health Care Services; Immigration; Stigma. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 4. Issue Publication Date: Aug, 2007.
AB - This is a commentary on the Care System Assessment (CSA) Project, utilizing a values-based health care framework to review the process undertaken by the three participating Ryan White CARE Act grantee sites. The CSA Project participants' dedication to the well-being of their communities reinforced the inclusion, active involvement, and participation of all stakeholders. That key community members had previously chosen not to participate in planning efforts or seek care because of stigma and fear in new immigrant populations was noted by all three sites as a major issue to address in their future planning. The sites selected for the CSA Project demonstrated that community-based Planning Councils, engaged with representatives from the target population, can assess, identify, and provide effective interventions sensitized to the needs of underserved, resilient clients. They also demonstrated that meeting these needs to enhance the common good of the community may require an increased respect for diversity. The CSA Project is one leadership exemplar of providers and clients coming together to find the common good of quality health care for people living with HIV and AIDS These grantee providers and their clients are intimately engaged in this paradigm shift and are taking the lead to redefine the type of health and support services they must provide within the context of the U.S. health care system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Care System Assessment Project
KW - values-based health care planning
KW - health care delivery
KW - HIV
KW - AIDS
KW - immigrants
KW - stigma
KW - 2007
KW - Health Care Delivery
KW - Health Service Needs
KW - HIV
KW - Social Values
KW - Treatment Planning
KW - AIDS
KW - Community Involvement
KW - Health Care Services
KW - Immigration
KW - Stigma
KW - 2007
DO - 10.1353/hpu.2007.0074
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13877-015&site=ehost-live&scope=site
UR - baranda-naranjo@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13797-005
AN - 2007-13797-005
AU - Smith, Derek R.
T1 - Longitudinal trends of alcohol and tobacco consumption among Australian physicians and nurses, 1989-2005.
JF - Journal of Substance Use
JO - Journal of Substance Use
JA - J Subst Use
Y1 - 2007/08//
VL - 12
IS - 4
SP - 267
EP - 280
CY - US
PB - Informa Healthcare
SN - 1465-9891
SN - 1475-9942
AD - Smith, Derek R., International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2007-13797-005. Partial author list: First Author & Affiliation: Smith, Derek R.; International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan. Other Publishers: Taylor & Francis. Release Date: 20071126. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Nurses; Physicians; Tobacco Smoking; Risk Assessment. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Aug, 2007.
AB - Aim: This study examined alcohol and tobacco consumption trends among a national sample of Australian health care workers between 1989 and 2005. Method: Alcohol and tobacco smoking data specific for physicians and nurses was obtained during four national health surveys. Data were analysed by alcohol consumption level, tobacco smoking status, job category and year of study. The relative risk of substance use between physicians, nurses and the general Australian population was also evaluated. Results: The proportion of Australian physicians and nurses with risky alcohol consumption habits appears to have fluctuated over time, particularly among nurses. Although tobacco smoking among Australian nurses has declined in recent years, the relatively low proportion of physician smokers remained fairly stable over the same time period. Both professional groups were considerably less likely to use tobacco when compared with the general population. Conclusion: This study provides one of the first clear insights into longitudinal substance use trends among Australian health care workers during the past 17 years. A sustained reduction in alcohol and tobacco use must continue in future, so that they remain exemplars at the forefront of anti-substance abuse programmes in the community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol consumption
KW - physicians
KW - tobacco smoking
KW - nurses
KW - risk analysis
KW - 2007
KW - Alcohol Drinking Patterns
KW - Nurses
KW - Physicians
KW - Tobacco Smoking
KW - Risk Assessment
KW - 2007
DO - 10.1080/14659890601157679
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13797-005&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8202-2523
UR - smith@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00456-008
AN - 2008-00456-008
AU - Nebbitt, Von E.
AU - House, Laura E.
AU - Thompson, Sanna J.
AU - Pollio, David E.
T1 - Successful transition of runaway/homeless youth from shelter care.
JF - Journal of Child and Family Studies
JO - Journal of Child and Family Studies
JA - J Child Fam Stud
Y1 - 2007/08//
VL - 16
IS - 4
SP - 545
EP - 555
CY - Germany
PB - Springer
SN - 1062-1024
SN - 1573-2843
AD - Nebbitt, Von E., E. Franklin Fraser Center for Social Work Research, School of Social Work, Howard University, 601 Howard Place, NW, Washington, DC, US, 20059
N1 - Accession Number: 2008-00456-008. Partial author list: First Author & Affiliation: Nebbitt, Von E.; E. Franklin Fraser Center for Social Work Research, School of Social Work, Howard University, Washington, DC, US. Release Date: 20080211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Family; Homeless; Resilience (Psychological); Runaway Behavior; Shelters. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug, 2007.
AB - Previous research indicates that runaway and homeless youth often achieve positive outcomes after shelter stays however few studies have examined how these outcomes are achieved. This study employs qualitative methods to explicate this phenomenon. Twenty-five providers and 21 youth from four shelters participated in this study. Youth were recruited who had completed shelter care and returned home for minimally six months. Multiple raters identified themes and created a conceptual model. While in shelter, youths experienced structure and freedom, and the family experienced respite. Once youth became involved in treatment, the family re-connected and the youth returned home. After returning home, youth and family become involved in follow-up services. Results from our study provide insight into the process through which runaway/homeless youth return home after a shelter stay. Our findings emphasize the need for continued change by all members of the family system, highlighting the need for continued intervention to maintain positive changes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - successful transition
KW - runaway/homeless youth
KW - shelter care
KW - family reunification
KW - resilience
KW - 2007
KW - Family
KW - Homeless
KW - Resilience (Psychological)
KW - Runaway Behavior
KW - Shelters
KW - 2007
DO - 10.1007/s10826-006-9105-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00456-008&site=ehost-live&scope=site
UR - vnebbitt_@howard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-10849-014
AN - 2007-10849-014
AU - Rhodes, Tim
AU - Watts, Louise
AU - Davies, Sarah
AU - Martin, Anthea
AU - Smith, Josie
AU - Clark, David
AU - Craine, Noel
AU - Lyons, Marion
T1 - Risk, shame and the public injector: A qualitative study of drug injecting in South Wales.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2007/08//
VL - 65
IS - 3
SP - 572
EP - 585
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Rhodes, Tim
N1 - Accession Number: 2007-10849-014. PMID: 17475383 Partial author list: First Author & Affiliation: Rhodes, Tim; Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, London, United Kingdom. Release Date: 20070917. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Environment; Intravenous Drug Usage; Life Experiences; Risk Taking; Shame. Minor Descriptor: Communities; Fear; Intervention; Narratives; Violence. Classification: Substance Abuse & Addiction (3233); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: United Kingdom. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Aug, 2007.
AB - Drug injecting in public places is associated with elevated health harm among injecting drug users (IDUs). Yet there is little research exploring the lived experience of injecting in public places, and specifically, a need to explore the interplay of public injecting environments, risk practices and social marginalisation. We undertook 49 qualitative interviews with IDUs in South Wales, UK, in six locations. Analyses focused on injectors' narratives of injecting in public places and risk identity. Findings show how the lived experience of public injecting feeds a pervasive sense of risk and 'otherness' among street injectors, in which public injecting environments act as contextual amplifiers of social marginalisation. Injecting in public places was characterised by urgency associated with a fear of interruption, a need to maintain privacy to prevent public exposure, and an awareness or sense of shame. We argue that daily interactions involving public exposure of injecting status, combined with the negative social meanings ascribed to public places used for injection, are experienced as potentially degrading to one's sense of self. We conclude that the public injecting environment is experienced in the context of other forms of public shaming in the lives of street injectors, and is thus productive of symbolic violence. This highlights tensions between strategies seeking to create safer communities and environmental interventions seeking to reduce drug-related health harm, including recent innovations such as the 'drug consumption room' (DCR). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk
KW - shame
KW - public injector
KW - injecting drug users
KW - lived experience
KW - social marginalization
KW - health harm
KW - environmental interventions
KW - 2007
KW - Environment
KW - Intravenous Drug Usage
KW - Life Experiences
KW - Risk Taking
KW - Shame
KW - Communities
KW - Fear
KW - Intervention
KW - Narratives
KW - Violence
KW - 2007
U1 - Sponsor: Welsh Assembly Government, United Kingdom. Recipients: No recipient indicated
U1 - Sponsor: Department of Health for England and Wales, United Kingdom. Other Details: Centre for Research on Drugs and Health Behaviour. Recipients: No recipient indicated
DO - 10.1016/j.socscimed.2007.03.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-10849-014&site=ehost-live&scope=site
UR - Tim.Rhodes@lshtm.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13604-014
AN - 2007-13604-014
AU - Wilson, Robin Taylor
AU - Adams-Cameron, Meg
AU - Burhansstipanov, Linda
AU - Roubidoux, Marilyn A.
AU - Cobb, Nathaniel
AU - Lynch, Charles F.
AU - Edwards, Brenda K.
T1 - Disparities in breast cancer treatment among American Indian, Hispanic and non-Hispanic White women enrolled in Medicare.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2007/08//
VL - 18
IS - 3
SP - 648
EP - 664
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Wilson, Robin Taylor
N1 - Accession Number: 2007-13604-014. PMID: 17675720 Partial author list: First Author & Affiliation: Wilson, Robin Taylor; Penn State College of Medicine, PA, US. Release Date: 20080616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Neoplasms; Medicare; Racial and Ethnic Differences; Treatment Duration. Minor Descriptor: American Indians; Diagnosis; Geriatrics; Human Females; Radiation Therapy; Surgery; Whites; Latinos/Latinas. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. Page Count: 17. Issue Publication Date: Aug, 2007.
AB - Because racial/ethnic disparities in breast cancer survival have persisted, we investigated differences in breast cancer treatment among American Indian, Hispanic, and non-Hispanic White (NHW) women. Surveillance, Epidemiology and End Results data linked to Medicare claims in New Mexico and Arizona (1987-1997) among enrollees aged 65 and older were used to identify treatment, treatment interval, and mortality risk associated with delays in care. We identified 2,031 women (67 American Indian, 333 Hispanic and 1,631 NHW) with time to treatment information. Treatment intervals from diagnosis to surgery and surgery to radiation, were significantly greater for American Indian women than for NHW women. This disparity remained statistically significant after adjustment for age, stage, grade, year of diagnosis, poverty, and distance to care. There was no statistically significant difference in treatment among Hispanic women. Further, American Indian women without surgery within 6 months experienced a 5.6-fold higher breast cancer mortality. The duration of time to surgery and radiation has not been previously reported for American Indian women. These results suggest older American Indian women experience significant delays in cancer treatment, resulting in greater breast cancer mortality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breast cancer treatment
KW - American Indian vs Hispanic vs White women enrolled in Medicare
KW - racial & ethnic disparities
KW - geriatrics
KW - treatment intervals from diagnosis to surgery to radiation
KW - 2007
KW - Breast Neoplasms
KW - Medicare
KW - Racial and Ethnic Differences
KW - Treatment Duration
KW - American Indians
KW - Diagnosis
KW - Geriatrics
KW - Human Females
KW - Radiation Therapy
KW - Surgery
KW - Whites
KW - Latinos/Latinas
KW - 2007
U1 - Sponsor: National Cancer Institute. Grant: N01-PC-67008 Mod. No. 4 & No. 12. Other Details: SEER Special Studies Grant. Recipients: No recipient indicated
DO - 10.1353/hpu.2007.0071
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13604-014&site=ehost-live&scope=site
UR - rwilson@psu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13032-008
AN - 2007-13032-008
AU - Mofidi, Mahyar
AU - DeVellis, Robert F.
AU - DeVellis, Brenda M.
AU - Blazer, Dan G.
AU - Panter, A. T.
AU - Jordan, Joanne M.
T1 - The relationship between spirituality and depressive symptoms: Testing psychosocial mechanisms.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 2007/08//
VL - 195
IS - 8
SP - 681
EP - 688
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - DeVellis, Brenda M., University of North Carolina, 309 Rosenau Hall, CB No. 7440, Chapel Hill, NC, US, 27599-7440
N1 - Accession Number: 2007-13032-008. PMID: 17700301 Partial author list: First Author & Affiliation: Mofidi, Mahyar; US Department of Health and Human Services, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20071015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: DeVellis, Brenda M. Major Descriptor: Major Depression; Psychosocial Factors; Spirituality. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Tests & Measures: Daily Spiritual Experiences Scale; Instrumental-Expressive Social-Support Scale; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2007.
AB - Although many studies suggest lower rates of depressive symptoms in those who report greater spirituality, few have investigated the mechanisms by which spirituality might relate to depressive symptoms. The current study aimed to elucidate potential psychosocial mechanisms that link these 2 variables. Data were drawn from a community-dwelling stratified sample of 630 racially diverse adults in rural North Carolina. Spirituality was assessed by 6 items of the Daily Spiritual Experiences Scale. Depressive symptoms were measured using 4 subscales from the Center for Epidemiological Studies-Depression. Hypothesized mediators were optimism, volunteering, and perceived social support. Structural equation modeling was used to test whether proposed mediators explain a link between spirituality and depressive symptoms. The model demonstrated a satisfactory fit. Spirituality was indirectly related to depressive symptoms. More specifically, spirituality was significantly associated with optimism and volunteering but not with social support, and optimism, volunteering and perceived social support were significantly associated with depressive symptoms. The link between spirituality and depressive symptoms is indirect. The relationship is mediated by optimism, volunteering, and social support. Findings present research and practice implications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depressive symptoms
KW - spirituality
KW - psychosocial mechanisms
KW - 2007
KW - Major Depression
KW - Psychosocial Factors
KW - Spirituality
KW - 2007
U1 - Sponsor: National Institute of Mental Health. Grant: RO1 MH64034-02. Recipients: DeVellis, Brenda M.
U1 - Sponsor: Centers for Disease Control and Prevention/Association of Schools of Public Health. Grant: S043; S1734; S3486. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Multipurpose Arthritis and Musculoskeletal Disease Center. Grant: 5-P60-AR30701. Recipients: Jordan, Joanne M.
DO - 10.1097/NMD.0b013e31811f4038
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13032-008&site=ehost-live&scope=site
UR - bdevelli@email.unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-12453-002
AN - 2007-12453-002
AU - Howell, Sue
AU - Westergaard, Greg
AU - Hoos, Beth
AU - Chavanne, Tara J.
AU - Shoaf, Susan E.
AU - Cleveland, Allison
AU - Snoy, Philip J.
AU - Suomi, Stephen J.
AU - Higley, J. Dee
T1 - Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques.
JF - American Journal of Primatology
JO - American Journal of Primatology
JA - Am J Primatol
Y1 - 2007/08//
VL - 69
IS - 8
SP - 851
EP - 865
CY - US
PB - John Wiley & Sons
SN - 0275-2565
SN - 1098-2345
AD - Howell, Sue, Mannheimer Foundation, Inc., PO Box 1235, Clewiston, FL, US, 33440
N1 - Accession Number: 2007-12453-002. PMID: 17330868 Partial author list: First Author & Affiliation: Howell, Sue; Division of Research and Development, Alpha Genesis, Inc., Yemassee, SC, US. Release Date: 20071008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Cerebrospinal Fluid; Dopamine; Monkeys; Serotonin. Minor Descriptor: Animal Aggressive Behavior; Animal Dominance; Death and Dying; Individual Differences. Classification: Physiological Processes (2540). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Aug, 2007.
AB - Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long-term outcome of young subjects with low CSF 5-HIAA concentrations as they mature into adults. In this study we examined longitudinal relations among serotonergic and dopaminergic functioning, as reflected in CSF metabolite concentrations, aggression, age at emigration, dominance rank, and mortality in free-ranging rhesus macaque (Macaco mulatto) males. Our results indicate long-term consistency of individual differences in levels of 5-HIAA in CSF in the subject population from the juvenile period of development through adulthood. We found a significant negative correlation between 5-HIAA concentrations measured in juveniles and rates of high-intensity aggression in the same animals as adults. Further, CSF 5-HIAA concentrations were lower in juveniles that died than in animals that survived. For the young animals that migrated there was a positive correlation between CSF 5-HIAA concentration and age at emigration, whereas for the animals that remained in their troop until later in sexual maturity there was a negative correlation between CSF 5-HIAA concentration and age of emigration. After animals emigrated to a new troop, social dominance rank in the new troop was positively correlated with early family social dominance rank, but inversely correlated with juvenile CSF 5-HIAA concentrations. Taken together, our findings suggest that males with low central serotonin levels early in life delay migration and show high levels of violence and premature death, but the males that survive achieve high rank. These findings indicate that longitudinal measures of serotonergic and dopaminergic functioning are predictive of major life-history outcomes in nonhuman primate males. Low concentrations of CSF 5-HIAA are associated with negative life-history patterns characterized by social instability and excessive aggression, and positive life-history patterns characterized by higher dominance rank. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - individual differences
KW - serotonergic functioning
KW - dopaminergic functioning
KW - monkeys
KW - aggression
KW - dominance rank
KW - mortality
KW - cerebrospinal fluid
KW - age differences
KW - 2007
KW - Age Differences
KW - Cerebrospinal Fluid
KW - Dopamine
KW - Monkeys
KW - Serotonin
KW - Animal Aggressive Behavior
KW - Animal Dominance
KW - Death and Dying
KW - Individual Differences
KW - 2007
U1 - Sponsor: Alpha Genesis, Inc.. Grant: 223-92-1101. Other Details: Food and Drug Administration. Recipients: No recipient indicated
DO - 10.1002/ajp.20369
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-12453-002&site=ehost-live&scope=site
UR - suehowell@bellsouth.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13763-003
AN - 2007-13763-003
AU - Mark, Tami L.
AU - Levit, Katharine R.
AU - Buck, Jeffrey A.
AU - Coffey, Rosanna M.
AU - Vandivort-Warren, Rita
T1 - Mental health treatment expenditure trends, 1986-2003.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/08//
VL - 58
IS - 8
SP - 1041
EP - 1048
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Mark, Tami L., Thomson Healthcare, 4301 Connecticut Ave., N.W., Washington, DC, US, 20008
N1 - Accession Number: 2007-13763-003. PMID: 17664514 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Healthcare, Washington, DC, US. Release Date: 20071119. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Medicaid; Mental Health Services; Trends. Classification: Health & Mental Health Services (3370). Population: Human (10); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2007.
AB - Objective: This study determined spending on mental health treatment in the United States over time by provider and payer relative to all health spending. Methods: Estimates were developed to be consistent with the National Health Expenditure Accounts. Numerous public data sources were used. Results: Mental health treatment expenditures grew from $33 billion in 1986 to $100 billion in 2003. In real 2003 dollars, spending per capita on mental health treatment rose from $205 to $345. The average annual nominal total mental health growth rate was 6.7%. In comparison, total health care expenditures increased by 8.0%. As a result of the slower growth rate of mental health expenditures compared with all health spending, mental health fell from 8% of all health expenditures in 1986 to 6% in 2003. Total national health spending increased by approximately $1.175 trillion from 1986 to 2003; of this, 6% is attributed to an increase in mental health spending. The mix of services has changed, with more care being provided through prescription drugs and in outpatient settings and less in inpatient settings. Payer mix has also shifted, with Medicaid taking a more prominent role. Conclusions: Spending on mental health treatment has increased over the past decade, reflecting increases in the number of individuals receiving mental health treatment, particularly prescription drugs and outpatient treatment. Changes in payer and provider mix raise new challenges for ensuring quality and access. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - treatment expenditure trends
KW - US
KW - Medicaid
KW - 2007
KW - Health Care Costs
KW - Medicaid
KW - Mental Health Services
KW - Trends
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1176/appi.ps.58.8.1041
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13763-003&site=ehost-live&scope=site
UR - tami.mark@thomson.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13763-009
AN - 2007-13763-009
AU - Wolff, Nancy
AU - Blitz, Cynthia L.
AU - Shi, Jing
T1 - Rates of sexual victimization in prison for inmates with and without mental disorders.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/08//
VL - 58
IS - 8
SP - 1087
EP - 1094
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Wolff, Nancy, Center for Mental Health Services and Criminal Justice Research, Rutgers University, 30 College Ave, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2007-13763-009. PMID: 17664520 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20071119. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Prisoners; Prisons; Sexual Abuse; Victimization. Minor Descriptor: Posttraumatic Stress Disorder; Technology. Classification: Psychological Disorders (3210); Criminal Law & Adjudication (4230). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Aug, 2007.
AB - Objective: This study estimated the rates of sexual victimization among prison inmates with and without a mental disorder. Methods: The study sampled inmates aged 18 or older in 13 prisons within a single mid-Atlantic state prison system (12 facilities for men and one for women). A total of 7,528 inmates completed the survey instrument, which was administered by audio-computer-assisted technology. Of the 6,964 male respondents, 58.5% were African American, 16.2% were non-Hispanic white, 19.8% were Hispanic, and 5.5% were of another race or ethnicity. Of the 564 female respondents, 48.4% were African American, 30.9% were non-Hispanic white, 14.4% were Hispanic, and 7.3% were of another race or ethnicity. Mental disorder was based on self-reported previous mental health treatment for particular mental disorders. Sexual victimization was measured by using questions adapted from the National Violence Against Women and Men surveys. Results: Approximately one in 12 male inmates with a mental disorder reported at least one incident of sexual victimization by another inmate over a six-month period, compared with one in 33 male inmates without a mental disorder. Among those with a mental disorder, sexual victimization was three times as high among female inmates (23.4%) as among male inmates (8.3%). African-American and Hispanic inmates with a mental disorder, independent of gender, reported higher rates of sexual victimization than their non-Hispanic white counterparts. Conclusions: Prisons are hazardous places. Steps must be taken to protect inmates from predators inside prison, to screen them for posttraumatic stress disorder, to provide trauma-related treatment, and to keep them safe. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sexual victimization
KW - prisons
KW - inmates
KW - mental disorders
KW - computer assisted technology
KW - posttraumatic stress disorder
KW - 2007
KW - Mental Disorders
KW - Prisoners
KW - Prisons
KW - Sexual Abuse
KW - Victimization
KW - Posttraumatic Stress Disorder
KW - Technology
KW - 2007
U1 - Sponsor: US Department of Justice, Office of Justice Programs, US. Grant: OJP-2004-RP-BX-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: P20-MH-66170. Recipients: No recipient indicated
DO - 10.1176/appi.ps.58.8.1087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13763-009&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ohyama, M.
AU - Otake, T.
AU - Adachi, S.
AU - Kobayashi, T.
AU - Morinaga, K.
T1 - A Comparison of the Production of Reactive Oxygen Species by Suspended Particulate Matter and Diesel Exhaust Particles with Macrophages.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2007/08/02/Aug2007 Supplement 1
VL - 19
M3 - Article
SP - 157
EP - 160
SN - 08958378
AB - Oxidative stress has emerged as a pivotal mechanism that underlies the toxic pulmonary effects of suspended particulate matter (SPM). Experimental evidence shows that redox-active transition metals, redox-cycling quinoids, and polycyclic aromatic hydrocarbons (PAHs) contained in SPM act synergistically, producing reactive oxygen species (ROS). The direct production of superoxide anion and the damaging hydroxyl radical has been studied in aqueous and dimethyl sulfoxide (DMSO) suspensions of SPM both with and without H2O2; however, no study has reported on the release of ROS from ingesting macrophages with SPM. We investigated the time course of the ability to induce lucigenin-dependent chemiluminescence (CL) from human monocyte-derived macrophages exposed to SPM, carbon black particles, and diesel exhaust particles (DEP). We also examined hydroxyl radical generation from the same experimental system using the 2-deoxy-d-robse method. We found an increase of CL for SPM, but not for carbon black particles or for DEP. Hydroxyl radical generation was observed in both SPM and DEP, but the release from DEP was more frequent than that from SPM. These results suggest that certain components of SPM are important in the response of ROS from ingesting macrophages with SPM, and that those components are discharged from SPM into the atmosphere. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic compounds
KW - Oxidation-reduction reaction
KW - Cell-mediated cytotoxicity
KW - Oxidative stress
KW - Killer cells
KW - Macrophages
KW - Antigen presenting cells
KW - Connective tissue cells
KW - Immunocompetent cells
N1 - Accession Number: 26641302; Ohyama, M. 1; Email Address: ohyama@iph.pref.osaka.jp; Otake, T. 1; Adachi, S. 2; Kobayashi, T. 3; Morinaga, K. 4; Affiliations: 1: Osaka Prefectural Institute of Public Health, Osaka; 2: Department of Public Health, Sagami Women's University, Kanagawa; 3: National Institute for Environmental Studies, Tsukuba; 4: Japanese National Institute of Occupational Safety and Health, Kawasaki, Japan; Issue Info: Aug2007 Supplement 1, Vol. 19, p157; Thesaurus Term: Polycyclic aromatic compounds; Thesaurus Term: Oxidation-reduction reaction; Thesaurus Term: Cell-mediated cytotoxicity; Subject Term: Oxidative stress; Subject Term: Killer cells; Subject Term: Macrophages; Subject Term: Antigen presenting cells; Subject Term: Connective tissue cells; Subject Term: Immunocompetent cells; Number of Pages: 4p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1080/08958370701496103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26641302&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dankovic, David
AU - Kuempel, Eileen
AU - Wheeler, Matthew
T1 - An Approach to Risk Assessment for TiO2.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2007/08/02/Aug2007 Supplement 1
VL - 19
M3 - Article
SP - 205
EP - 212
SN - 08958378
AB - Titanium dioxide (TiO2) is a poorly soluble, low-toxicity (PSLT) particle. Fine TiO2 (<2.5 μm) has been shown to produce lung tumors in rats exposed to 250 mg/m3, and ultrafine TiO2 (< 0.1 μm diameter) has been shown to produce lung tumors in rats at 10 mg/m3. We have evaluated the rat dose-response data and conducted a quantitative risk assessment for TiO2. Preliminary conclusions are: (1) Fine and ultrafine TiO2 and other PSLT particles show a consistent dose-response relationship when dose is expressed as particle surface area; (2) the mechanism of TiO2 tumor induction in rats appears to be a secondary genotoxic mechanism associated with persistent inflammation; and (3) the inflammatory response shows evidence of a nonzero threshold. Risk estimates for TiO2 depend on both the dosimetric approach and the statistical model that is used. Using 7 different dose-response models in the U.S. Environmental Protection Agency (EPA) benchmark dose software, the maximum likelihood estimate (MLE) rat lung dose associated with a 1 per 1000 excess risk ranges from 0.0076 to 0.28 m2/g-lung of particle surface area, with 95% lower confidence limits (LCL) of 0.0059 and 0.042, respectively. Using the ICRP particle deposition and clearance model, estimated human occupational exposures yielding equivalent lung burdens range from approximately 1 to 40 mg/m3 (MLE) for fine TiO2, with 95% LCL approximately 0.7-6 mg/m3. Estimates using an interstitial sequestration lung model are about one-half as large. Bayesian model averaging techniques are now being explored as a method for combining the various estimates into a single estimate, with a confidence interval expressing model uncertainty. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Health risk assessment
KW - Public health
KW - Environmental health
KW - Hazardous substances
KW - Toxicity testing
KW - Experimental toxicology
KW - Preventive medicine
KW - Health status indicators
N1 - Accession Number: 26641295; Dankovic, David 1; Email Address: dad4@cdc.gov; Kuempel, Eileen 1; Wheeler, Matthew 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Aug2007 Supplement 1, Vol. 19, p205; Thesaurus Term: Risk assessment; Thesaurus Term: Health risk assessment; Thesaurus Term: Public health; Thesaurus Term: Environmental health; Thesaurus Term: Hazardous substances; Thesaurus Term: Toxicity testing; Thesaurus Term: Experimental toxicology; Subject Term: Preventive medicine; Subject Term: Health status indicators; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 4 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/08958370701497754
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26641295&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105828106
T1 - CARE Act planning for unmet need.
AU - Hopson DP
AU - Morgan DH
AU - Gray SH
AU - Conviser R
Y1 - 2007/08/02/2007 Supplement
N1 - Accession Number: 105828106. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2007 Supplement. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9103800.
KW - Health and Welfare Planning -- Legislation and Jurisprudence
KW - Health Services Accessibility -- Legislation and Jurisprudence
KW - Health Services Needs and Demand
KW - HIV Infections -- Drug Therapy
KW - Medically Underserved Area
KW - Program Development
KW - Primary Health Care
KW - United States
SP - 1
EP - 7
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 18
IS - 3
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - The Ryan White CARE Act, a safety net program first enacted in 1990, provides health and support services to people living with HIV (PLWH) in the U.S. through several Titles. Recipients of CARE Act funds--particularly metropolitan areas and States under Titles I and II, respectively--prioritize and allocate funds to cover unmet service needs. In the 2000 reauthorization of the CARE Act, Title I and II grantees were directed to determine unmet needs for services. This paper describes a process by which the HIV/AIDS Bureau of the Health Resources and Services Administration of the U.S. Department of Health and Human Services has assisted grantees in developing tools to make quantitative estimates of the unmet need for HIV primary care services. The process enables grantees to identify underserved populations and implement strategies to bring them into regular primary care. The Care System Assessment Demonstration Project supplements these tools.
SN - 1049-2089
AD - Director of the HIV/AIDS Bureau at the Health Resources and Services Administration in the Department of Health and Human Services
U2 - PMID: 17938462.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105828106&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Temple, Robert
AU - Stockbridge, Norman L.
T1 - IN RESPONSE.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/08/07/
VL - 147
IS - 3
M3 - Letter
SP - 215
EP - 216
SN - 00034819
AB - A response by Robert Temple to a letter to the editor about his article regarding the approval of the U.S. Food and Drugs Administration on Bidil, a drug for heart failure, is presented.
KW - LETTERS to the editor
KW - DRUGS -- Analysis
N1 - Accession Number: 26096410; Temple, Robert 1 Stockbridge, Norman L. 1; Affiliation: 1: U.S. Food and Drug Administration, Silver Spring, MD 20993-0002; Source Info: 8/7/2007, Vol. 147 Issue 3, p215; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Analysis; Number of Pages: 2p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26096410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ahn, Hongshik
AU - Moon, Hojin
AU - Fazzari, Melissa J.
AU - Lim, Noha
AU - Chen, James J.
AU - Kodell, Ralph L.
T1 - Classification by ensembles from random partitions of high-dimensional data
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2007/08/15/
VL - 51
IS - 12
M3 - Article
SP - 6166
EP - 6179
SN - 01679473
AB - Abstract: A robust classification procedure is developed based on ensembles of classifiers, with each classifier constructed from a different set of predictors determined by a random partition of the entire set of predictors. The proposed methods combine the results of multiple classifiers to achieve a substantially improved prediction compared to the optimal single classifier. This approach is designed specifically for high-dimensional data sets for which a classifier is sought. By combining classifiers built from each subspace of the predictors, the proposed methods achieve a computational advantage in tackling the growing problem of dimensionality. For each subspace of the predictors, we build a classification tree or logistic regression tree. Our study shows, using four real data sets from different areas, that our methods perform consistently well compared to widely used classification methods. For unbalanced data, our approach maintains the balance between sensitivity and specificity more adequately than many other classification methods considered in this study. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLASSIFICATION
KW - REGRESSION analysis
KW - MATHEMATICAL statistics
KW - STATISTICS
KW - Class prediction
KW - Classification tree
KW - Cross validation
KW - Logistic regression
KW - Majority voting
KW - Risk profiling
N1 - Accession Number: 26035971; Ahn, Hongshik 1; Email Address: hahn@ams.sunysb.edu Moon, Hojin 2 Fazzari, Melissa J. 1 Lim, Noha 1 Chen, James J. 2 Kodell, Ralph L. 3; Affiliation: 1: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794-3600, USA 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: Department of Biostatistics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 781, Little Rock, AR 72205, USA; Source Info: Aug2007, Vol. 51 Issue 12, p6166; Subject Term: CLASSIFICATION; Subject Term: REGRESSION analysis; Subject Term: MATHEMATICAL statistics; Subject Term: STATISTICS; Author-Supplied Keyword: Class prediction; Author-Supplied Keyword: Classification tree; Author-Supplied Keyword: Cross validation; Author-Supplied Keyword: Logistic regression; Author-Supplied Keyword: Majority voting; Author-Supplied Keyword: Risk profiling; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.csda.2006.12.043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26035971&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, Arthur L.
AU - Habjan, Matthew C.
AU - Kihong Park
T1 - Real-Time Estimation of Elemental Carbon Emitted from a Diesel Engine.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2007/08/15/
VL - 41
IS - 16
M3 - Article
SP - 5783
EP - 5788
SN - 0013936X
AB - New Mining Safety and Health Administration (MSHA) regulations limit the mass concentration of airborne diesel particulate matter (DPM) or, more specifically, the concentration of elemental carbon (EC), in underground mines. The mine operators are responding by introducing a variety of controls to reduce DPM in the mines, potentially including the evaluation of new maintenance procedures to reduce underground mine vehicle emissions. There is currently a lack of an inexpensive and dependable method to directly measure the DPM concentration emitted from the vehicle tailpipe. To that end, this work demonstrated a simple field portable method for estimating the mass concentration of elemental carbon exiting the tailpipe of a diesel engine using a direct reading photometer. Simultaneous measurements of tailpipe exhaust were made with a Thermo Electron Personal DataRAM 1200 photometer (particulate mass concentration based on light scattering) and by analyzing PM2,5 and PM1,0 samples collected on quartz fiber filters using the National Institute of Occupational Safety and Health (NIOSH) method 5040 (mass concentration of EC via thermal-optical method). Results indicate surprisingly good correlation (R² = 0.97) of the two methods when the data are adjusted for relative humidity (RH) and corrected using an empirically generated calibration factor. Although preliminary, it may be possible to implement this method in maintenance shops to monitor emission trends and to compare emissions of various vehicles in a fleet. Such data will be useful for fleet planning to meet new air quality standards. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental monitoring
KW - Air pollution monitoring
KW - Carbon offsetting
KW - Emission control
KW - Carbon -- Environmental aspects
KW - Emissions (Air pollution)
KW - Air pollution
KW - Air quality
KW - Diesel motors
N1 - Accession Number: 26322861; Miller, Arthur L. 1; Email Address: ALMiller@cdc.gov; Habjan, Matthew C. 1; Kihong Park 2; Affiliations: 1: National Institute for Occupational Safety and Health, Spokane, Washington; 2: Gwangju Institute of Science and Technology, Gwangju, Korea; Issue Info: 8/15/2007, Vol. 41 Issue 16, p5783; Thesaurus Term: Environmental monitoring; Thesaurus Term: Air pollution monitoring; Thesaurus Term: Carbon offsetting; Thesaurus Term: Emission control; Thesaurus Term: Carbon -- Environmental aspects; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Air pollution; Thesaurus Term: Air quality; Subject Term: Diesel motors; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 541620 Environmental Consulting Services; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1021/es070150a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26322861&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tournas, V.H.
AU - Kohn, J.S.
AU - Katsoudas, E.J.
T1 - The identification of antibacterial compounds for the development of enhanced media for the detection of foodborne fungi
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2007/08/15/
VL - 118
IS - 1
M3 - Article
SP - 83
EP - 86
SN - 01681605
AB - Abstract: In an effort to identify a more suitable antibiotic for utilization in mycological media, 12 food borne fungal species from various genera including Alternaria alternata, Aspergillus flavus, A. niger, Eurotium chevalieri, Fusarium moniliforme, Penicillium sp., Rhizopus stolonifer, Saccharomyces cerevisiae, Candida tropicalis, Geotrichum candidum, Rhodotorula glutinis and Kluyveromyces thermotolerans along with 21 chloramphenicol-resistant bacterial isolates from fresh produce and ATCC cultures of Pseudomonas aeruginosa, P. fluorescens, E. coli, Pectobacterium carotovorum, Bacillus cereus and Staphylococcus spp. were tested for their abilities to grow on dichloran rose bengal agar containing various levels of gentamicin, chlortetracycline or chloramphenicol. Results indicated that all fungal isolates except for Rh. glutinis and R. stolonifer grew well on all media tested. Rh. glutinis did not grow on media containing gentamicin whereas R. stolonifer produced very restricted or no growth on these media. All bacterial isolates from fresh produce, P. aeruginosa (ATCC 27853) and P. fluorescens (ATCC BAA-477) grew well at 100, 125 and 150 mg chloramphenicol/liter medium, but they did not grow on media containing chlortetracycline (100, 125, or 150 mg/L) or gentamicin (15, 25, or 35 mg/L). P. aeruginosa (ATCC 10145) grew well on media containing chloramphenicol or gentamicin, but not in the presence of chlortetracycline. P. carotovorum, E. coli, B. cereus and Staphylococcus spp. did not grow on any of the selective media tested. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Escherichia coli
KW - Chloramphenicol
KW - Fusarium oxysporum
KW - Bacterial and fungal resistance
KW - Chlortetracycline
KW - Gentamicin
N1 - Accession Number: 26036016; Tournas, V.H. 1; Email Address: valerie.tournas@fda.hhs.gov; Kohn, J.S. 2; Katsoudas, E.J. 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; 2: Northeast Regional Laboratory, Food and Drug Administration, 158-15 Liberty Ave., Jamaica, NY 11433, USA; Issue Info: Aug2007, Vol. 118 Issue 1, p83; Thesaurus Term: Antibacterial agents; Thesaurus Term: Escherichia coli; Subject Term: Chloramphenicol; Subject Term: Fusarium oxysporum; Author-Supplied Keyword: Bacterial and fungal resistance; Author-Supplied Keyword: Chlortetracycline; Author-Supplied Keyword: Gentamicin; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2007.04.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26036016&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Attfield, M. D.
AU - Petsonk, E. L.
T1 - Advanced Pneumoconiosis Among Working Underground Coal Miners--Eastern Kentucky and Southwestern Virginia, 2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/08/15/
VL - 298
IS - 7
M3 - Article
SP - 734
EP - 736
SN - 00987484
AB - This article presents the results of a study by the U.S. Centers for Disease Control and Prevention on advanced pneumoconiosis among working underground coal miners in eastern Kentucky and southwestern Virginia in 2006. The study found that despite regulations for underground coal mines, 37 advanced cases of a pneumoconiosis were identified in 7 counties. Case descriptions are presented. The field survey found that silica dust is more toxic to the lungs than coal mine dust. The report suggests that there are several reasons to be considered for the continued occurrence of the disease including possible regional differences in coal dust toxicity and possible failure to keep to national safety standards in mining operations.
KW - LUNGS -- Dust diseases
KW - COAL miners
KW - DISEASES
KW - SILICA dust
KW - LUNG diseases
KW - MINERAL dusts
KW - MINERAL industries -- Dust control
KW - KENTUCKY
KW - WEST Virginia
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 26186730; Attfield, M. D. 1 Petsonk, E. L. 1; Affiliation: 1: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC.; Source Info: 8/15/2007, Vol. 298 Issue 7, p734; Subject Term: LUNGS -- Dust diseases; Subject Term: COAL miners; Subject Term: DISEASES; Subject Term: SILICA dust; Subject Term: LUNG diseases; Subject Term: MINERAL dusts; Subject Term: MINERAL industries -- Dust control; Subject Term: KENTUCKY; Subject Term: WEST Virginia; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - Woodruff, Jeffrey T.
T1 - Use of liquid chromatography–mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2007/08/15/
VL - 44
IS - 4
M3 - Article
SP - 887
EP - 893
SN - 07317085
AB - Abstract: An herbal dietary supplement, marketed as a natural product for the enhancement of sexual function, was analyzed by HPLC with photodiode array and mass spectral detection and found to contain a compound related to the synthetic phosphodiesterase-5 (PDE-5) inhibitors. Based on UV spectra, mass spectra and direct infusion MS n , the structure of the compound was tentatively identified as a sildenafil analogue in which the sulfonyl group had been replaced with an acetyl group. This new analogue is similar to acetildenafil, a previously reported sildenafil analogue, but differs in that it contains an N-methyl group where acetildenafil contains an N-ethyl group. The structure of the unknown was unequivocally established by chemical cleavage of the phenacylamine group of the molecule to generate N-methylpiperazine; other cleavage products matched those generated from acetildenafil. Since the new compound has one less CH2 group than acetildenafil, it was named nor-acetildenafil. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - LIQUID chromatography
KW - MASS spectrometry
KW - PHOSPHODIESTERASES
KW - Acetildenafil
KW - Dietary supplement
KW - Erectile dysfunction
KW - Liquid chromatography–mass spectrometry (LC–MS)
KW - Nor-acetildenafil
KW - Phosphodiesterase-5 inhibitor
KW - Sildenafil analogue
N1 - Accession Number: 25935762; Reepmeyer, John C.; Email Address: john.reepmeyer@fda.hhs.gov Woodruff, Jeffrey T. 1; Affiliation: 1: US Food and Drug Administration, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA; Source Info: Aug2007, Vol. 44 Issue 4, p887; Subject Term: DIETARY supplements; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: PHOSPHODIESTERASES; Author-Supplied Keyword: Acetildenafil; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: Erectile dysfunction; Author-Supplied Keyword: Liquid chromatography–mass spectrometry (LC–MS); Author-Supplied Keyword: Nor-acetildenafil; Author-Supplied Keyword: Phosphodiesterase-5 inhibitor; Author-Supplied Keyword: Sildenafil analogue; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2007.04.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jove Graham
T1 - Effect of Bone Density on Vertebral Strength and Stiffness After Percutaneous Vertebroplasty.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2007/08/15/
VL - 32
IS - 18
M3 - Article
SP - E505
EP - E511
SN - 03622436
AB - STUDY DESIGN.: An ex vivo biomechanical study using cadaveric vertebral bodies. OBJECTIVE.: To determine how bone mineral density (BMD) affects mechanical strength and stiffness of the vertebral body after vertebroplasty, and to determine how the association between mechanical properties and BMD varies with amount of cement injected. SUMMARY OF BACKGROUND DATA.: Adverse events associated with vertebroplasty include cement leakage and adjacent fractures. Understanding effects of bone density and cement volume on mechanical properties may be important clinically to identify the minimum cement volume that will benefit the patient while minimizing risks of adverse events. METHODS.: The bone mineral density of 13 vertebral columns from adult white female cadavers was measured with DEXA. Vertebral bodies (n = 126) were assigned to 5 groups based on cement treatment: intact, untreated, 4% fill, 12% fill, and 24% fill. Treated specimens were first loaded asymmetrically to simulate a wedge compression fracture before injection with polymethylmethacrylate cement. Strength and stiffness were measured in axial compression. RESULTS.: Only the highest cement dose used (24% fill, 7 mL on average) had an effect on mechanical stiffness or strength. Within this group, stiffness was improved relative to untreated fractures but not restored to prefracture levels, and strength was enhanced beyond intact values. These improvements in stiffness and strength depended significantly on bone density, with highly osteoporotic samples benefitting the least. CONCLUSION.: Results suggest that highly osteoporotic patients may receive the least amount of improvement in mechanical properties after vertebroplasty. It is recommended, therefore, that cement volume be restricted to the amount needed for fracture reduction only because there may be a limit to the mechanical benefits that additional cement can offer, depending on patient bone density. Understanding these limitations can potentially minimize risks of adverse events. [ABSTRACT FROM AUTHOR]
AB - Copyright of Spine (03622436) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN body composition
KW - BONE density
KW - MUSCULOSKELETAL system
KW - ARTIFICIAL implants
N1 - Accession Number: 26269900; Jove Graham 1; Affiliation: 1: From the Divisions of *Solid and Fluid Mechanics, †Biostatistics, and §General, Neurological and Restorative Devices, Food & Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Rockville, MD; and ‡Department of Biomedical Engineering, George Washington University, Washington, DC.; Source Info: Aug2007, Vol. 32 Issue 18, pE505; Subject Term: HUMAN body composition; Subject Term: BONE density; Subject Term: MUSCULOSKELETAL system; Subject Term: ARTIFICIAL implants; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vo, Evanly
AU - Murray, David K.
AU - Scott, Tricia L.
AU - Attar, A.J.
T1 - Development of a novel colorimetric indicator pad for detecting aldehydes
JO - Talanta
JF - Talanta
Y1 - 2007/08/15/
VL - 73
IS - 1
M3 - Article
SP - 87
EP - 94
SN - 00399140
AB - Abstract: A colorimetric indicator was developed and a colorimetric indicator pad was fabricated for the rapid detection of aldehydes. The detection pad has two sides: an observation side on top and a barrier on the bottom. The top side contains a reagent which reacts directly with aldehydes to produce a color change, while the bottom side is coated with a double-sided plastic tape barrier to prevent the escape of chemicals. Sensitivity of the indicator pads was determined using the vapor sensitive ASTM F739 technique with the presence of the indicator. A significant indicator color change (yellow to red) occurred about 5min before the infrared analyzer response of the ASTM method. The chemical principle and reaction characterization of the test are described. The stability and potential interferences of the indicator pad were also examined by directly spiking aldehydes and compounds with other functional groups, respectively, onto the indicator pads. The newly developed aldehyde indicator pad should find utility in detecting aldehydes in both liquid and vapor phases and in collecting aldehyde permeation through PPE for further study. [Copyright &y& Elsevier]
AB - Copyright of Talanta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLORIMETRIC analysis
KW - ALDEHYDES
KW - ORGANIC compounds
KW - ORGANIC chemistry
KW - Aldehyde detector
KW - Development of colorimetric indicator
KW - Health and safety
KW - Skin chemical exposure
N1 - Accession Number: 25935086; Vo, Evanly 1; Email Address: Eav8@cdc.gov Murray, David K. 2 Scott, Tricia L. 3 Attar, A.J. 4; Affiliation: 1: Department of Health and Human Services, CDC/National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA 2: National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Road, Morgantown, WV 26505, USA 3: Department of Chemistry, West Virginia University, Morgantown, WV 26505, USA 4: Appealing Products Inc., 3400 Swift Dr, Raleigh, NC 27606, USA; Source Info: Aug2007, Vol. 73 Issue 1, p87; Subject Term: COLORIMETRIC analysis; Subject Term: ALDEHYDES; Subject Term: ORGANIC compounds; Subject Term: ORGANIC chemistry; Author-Supplied Keyword: Aldehyde detector; Author-Supplied Keyword: Development of colorimetric indicator; Author-Supplied Keyword: Health and safety; Author-Supplied Keyword: Skin chemical exposure; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.talanta.2007.03.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, R.B.
AU - Zidan, A.S.
AU - Funck, T.
AU - Tawakkul, M.A.
AU - Nguyenpho, A.
AU - Khan, M.A.
T1 - Quality by design: Characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2007/08/16/
VL - 341
IS - 1/2
M3 - Article
SP - 189
EP - 194
SN - 03785173
AB - Abstract: In the present work, a novel application of ultrasonic measurements is detailed to characterize nano-emulsion formulations as a part of the overall Quality by Design (QbD) goal. Ultrasonic resonator technology (URT) was utilized to measure sound velocity and absorption of self-nanoemulsified drug delivery systems (SNEDDs) consisting of various ratios of oil:surfactant:co-surfactant. A QbD concept was used to create different SNEDDs formulations utilizing sweet orange oil (oil), Emulphor-620 (surfactant), and Capmul (co-surfactant) by dissolving Cyclosporine A in oil. The mixture was emulsified in water and ultrasonic measurements were carried out in an ultrasonic resonator system isothermally for a period of about 15–20min. Compressibility of the individual components in the droplets, hydration of the droplets and the influence of the composition on droplet stability were studied by systematic ultrasonic measurements at a single resonator frequency. The adiabetic compressibilities for the oil, aqueous and interfacial components were 68, 44.6, and 53 [10−11 Pa−1], respectively as calculated using Urick''s equation. Also the ultrasonic absorption correlated droplet size of nano-emulsions linearly with R 2 of 0.84 indicating this can be used as an additional technique to measure the droplet size of nano-emulsions. Correlation of ultrasonic data with formulation components indicated that the ultrasonic velocity correlated negatively with increasing oil amount in the formulation as well as surfactant-to-cosurfactant ratios where as droplet diameter correlated positively with these formulation factors. It can be envisioned from the results that the compressibility of the media increases with the addition of the oily component and thus reducing the sound velocity. Thus URT enabled direct and convenient analysis of the physical properties as well as influence of formulation factors of nano-emulsions which is an important indication of stability of these nano-emulsions. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG delivery systems
KW - SURFACE active agents
KW - ULTRASONIC waves -- Speed
KW - PHARMACEUTICAL technology
KW - Characterization
KW - Self-nano-emulsified drug delivery systems
KW - Ultrasonic absorption
KW - Ultrasonic velocity
N1 - Accession Number: 25935923; Shah, R.B. 1 Zidan, A.S. 1 Funck, T. 2 Tawakkul, M.A. 1 Nguyenpho, A. 1 Khan, M.A. 1; Email Address: Mansoor.khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Life Sciences Bldg 64, Silver spring, MD 20993, United States 2: TF instruments Inc., Heidelberg, Germany; Source Info: Aug2007, Vol. 341 Issue 1/2, p189; Subject Term: DRUG delivery systems; Subject Term: SURFACE active agents; Subject Term: ULTRASONIC waves -- Speed; Subject Term: PHARMACEUTICAL technology; Author-Supplied Keyword: Characterization; Author-Supplied Keyword: Self-nano-emulsified drug delivery systems; Author-Supplied Keyword: Ultrasonic absorption; Author-Supplied Keyword: Ultrasonic velocity; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijpharm.2007.04.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Unger, Ellis F.
T1 - All Is Not Well in the World of Translational Research
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
Y1 - 2007/08/21/
VL - 50
IS - 8
M3 - Article
SP - 738
EP - 740
SN - 07351097
AB - It is not unusual for novel treatment strategies to fail in clinical trials, despite highly encouraging results in preclinical proof-of-concept studies. Typically, such “failures of translation” are blamed on the poor predictiveness of animal models. Often, however, the poor predictiveness of today’s preclinical proof-of-concept studies is related not to limitations of the models but to investigator bias and a lack of scientific rigor. The resulting false-positive results only serve to mislead the field and impede medical progress. With the resurgence of translational research, it is useful to examine some of the problems that plague these studies and consider their solutions. With thoughtful planning, execution, and analysis, it is possible to generate reliable and predictive data from preclinical proof-of-concept studies, results that should more rapidly advance medical progress. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American College of Cardiology (JACC) is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - ANIMAL models in research
KW - MEDICAL research
KW - CLINICAL medicine -- Research
KW - ANIMAL experimentation
N1 - Accession Number: 26248946; Unger, Ellis F. 1; Email Address: ellis.unger@fda.hhs.gov; Affiliation: 1: Division of Cardiovascular and Renal Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.; Source Info: Aug2007, Vol. 50 Issue 8, p738; Subject Term: CLINICAL trials; Subject Term: ANIMAL models in research; Subject Term: MEDICAL research; Subject Term: CLINICAL medicine -- Research; Subject Term: ANIMAL experimentation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jacc.2007.04.067
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105995833
T1 - All is not well in the world of translational research.
AU - Unger EF
Y1 - 2007/08/21/
N1 - Accession Number: 105995833. Language: English. Entry Date: 20080222. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 8301365.
KW - Animal Studies -- Standards
KW - Cardiovascular Diseases -- Therapy
KW - Study Design -- Standards
KW - Animals
SP - 738
EP - 740
JO - Journal of the American College of Cardiology (JACC)
JF - Journal of the American College of Cardiology (JACC)
JA - J AM COLL CARDIOL
VL - 50
IS - 8
CY - New York, New York
PB - Elsevier Science
SN - 0735-1097
AD - Division of Cardiovascular and Renal Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ellis.unger@fda.hhs.gov
U2 - PMID: 17707177.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Derek, SJ
AU - Marsh, SM
AU - Jackson, LL
T1 - Nonfatal Occupational Injuries and Illnesses-- United States, 2004.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/08/22/
VL - 298
IS - 8
M3 - Article
SP - 856
EP - 858
SN - 00987484
AB - The article focuses on data collected through a National Electronic Injury Surveillance System concerning nonfatal occupational injuries and illnesses in the U.S. in 2004. It states that the U.S. Centers for Disease Control and Prevention (CDC) uses the data to monitor injury trends and assist in prevention activities. It mentions that over 75% of nonfatal workplace injuries and illnesses were caused by contact with objects or equipment, bodily reactions or exertions, and falls. It states there was no substantial reduction in the overall number and rate of emergency department treated occupational injuries or illnesses from 1996 to 2004.
KW - TRENDS
KW - WORK-related injuries
KW - OCCUPATIONAL diseases
KW - WOUNDS & injuries -- Prevention
KW - INDUSTRIAL safety
KW - ACCIDENT prevention
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 26293829; Derek, SJ 1 Marsh, SM 1 Jackson, LL 1; Affiliation: 1: Division of Safety Research, National Institute for Occupational Safety and Health, CDC; Source Info: 8/22/2007, Vol. 298 Issue 8, p856; Subject Term: TRENDS; Subject Term: WORK-related injuries; Subject Term: OCCUPATIONAL diseases; Subject Term: WOUNDS & injuries -- Prevention; Subject Term: INDUSTRIAL safety; Subject Term: ACCIDENT prevention; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Forman, Dan
AU - West, Nathan
AU - Powell, Martin
AU - Francis, Janet
AU - Guy, Edward
T1 - Toxoplasma in cetaceans around the British Isles.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2007/08/25/
VL - 161
IS - 8
M3 - Letter
SP - 279
EP - 279
SN - 00424900
N1 - Accession Number: 66099944; Forman, Dan 1 West, Nathan 1 Powell, Martin 2 Francis, Janet 3 Guy, Edward 3; Affiliation: 1: Institute of Environmental Sustainability, Swansea University, Singleton Park, Swansea SA2 8PP 2: School of Applied Sciences, University of Glamorgan, Pontypridd CF37 1DL 3: Toxoplasma Reference Unit, National Public Health Service for Wales, Sgeti, Swansea SA2 8QA; Source Info: 8/25/2007, Vol. 161 Issue 8, p279; Number of Pages: 1/3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Proctor, Enola K.
AU - Knudsen, Kraig J.
AU - Fedoravicius, Nicole
AU - Hovmand, Peter
AU - Rosen, Aaron
AU - Perron, Brian
T1 - Implementation of Evidence-Based Practice in Community Behavioral Health: Agency Director Perspectives.
JO - Administration & Policy in Mental Health & Mental Health Services Research
JF - Administration & Policy in Mental Health & Mental Health Services Research
Y1 - 2007/09//
VL - 34
IS - 5
M3 - Article
SP - 479
EP - 488
SN - 0894587X
AB - The article focuses on the study which presents the views of mental health agency directors regarding the impending challenges upon the implementation of evidence-based practices in the U.S. According to the article, several of the problems include small scope of access to research, training costs as well as resistance of providers. In addition, it states that the research addresses that innovations that should be adopted when carrying out the program.
KW - MENTAL health services
KW - EVIDENCE-based medicine
KW - PHYSICIAN practice patterns
KW - MEDICAL care
KW - UNITED States
KW - Evidence-based practice
KW - Implementation
KW - Science and service
N1 - Accession Number: 31121317; Proctor, Enola K. 1; Email Address: ekp@wustl.edu Knudsen, Kraig J. 1,2; Email Address: knudsenk@mh.state.oh.us Fedoravicius, Nicole 1,3; Email Address: nfedoravicius@wustl.edu Hovmand, Peter 1; Email Address: phovmand@wustl.edu Rosen, Aaron 1; Email Address: aaronr@wustl.edu Perron, Brian 1; Email Address: bperron@gwbmail.wustl.edu; Affiliation: 1: George Warren Brown School of Social Work, Washington University in Saint Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO 63130-4899, USA 2: Ohio Department of Mental Health, Office of Program Evaluation and Research, 30 E. Broad Street, 8th Floor, Columbus, OH 43215-3430, USA 3: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in Saint Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO 63130-4899, USA; Source Info: Sep2007, Vol. 34 Issue 5, p479; Subject Term: MENTAL health services; Subject Term: EVIDENCE-based medicine; Subject Term: PHYSICIAN practice patterns; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: Evidence-based practice; Author-Supplied Keyword: Implementation; Author-Supplied Keyword: Science and service; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 10p; Document Type: Article
L3 - 10.1007/s10488-007-0129-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hnizdo, V.
T1 - Comment on "Preacceleration without radiation: The nonexistence of preradiation phenomenon," by J. A. Heras [Am. J. Phys. 74 (11), 1025-1030 (2006)].
JO - American Journal of Physics
JF - American Journal of Physics
Y1 - 2007/09//
VL - 75
IS - 9
M3 - Article
SP - 845
EP - 846
SN - 00029505
AB - The article discusses the contention of J. A. Heras concerning the presence of radiation in the preacceleration parts of a nonrunaway solution. According to the author, J. A. Heras assumed that there is no presence of radiation in the preacceleration parts of several of the nonrunaway solutions of the Abraham-Lorentz equation of motion involving a point change. The author argues that the arguments of J A. Heras is incorrect on account of the fact that the nonrunaway solutions of the Abraham-Lorentz equation features the unphysical property of preacceleration.
KW - ELECTRODYNAMICS
KW - RADIATION
KW - PHYSICS
KW - EMISSIVITY
KW - ELECTROKINETICS
KW - DYNAMICS
KW - MOTION
KW - FORCE & energy
KW - KINEMATICS
KW - HERAS, J. A.
N1 - Accession Number: 26405779; Hnizdo, V. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Source Info: Sep2007, Vol. 75 Issue 9, p845; Subject Term: ELECTRODYNAMICS; Subject Term: RADIATION; Subject Term: PHYSICS; Subject Term: EMISSIVITY; Subject Term: ELECTROKINETICS; Subject Term: DYNAMICS; Subject Term: MOTION; Subject Term: FORCE & energy; Subject Term: KINEMATICS; People: HERAS, J. A.; Number of Pages: 2p; Document Type: Article
L3 - 10.1119/1.2733682
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rader, Jeanne I.
AU - Delmonte, Pierluigi
AU - Trucksess, Mary W.
T1 - Recent studies on selected botanical dietary supplement ingredients.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 27
EP - 35
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - The market for botanical dietary supplements in the US has grown rapidly during the last 15 years. Use of newly introduced botanical ingredients has often outpaced an adequate scientific understanding of the ingredients themselves. This may lead to problems, including misidentification, mislabeling, adulteration, and toxicity related to the intended ingredient or one substituted for it. This article reviews recent work with several botanical ingredients ( Ephedra, Citrus species, Hoodia gordonii, Teucrium, isoflavones) that illustrates the complexity of the current situation and approaches that contribute to ensuring the quality of botanical ingredients. Recent work with contamination of botanical products by mycotoxins is also reviewed. The need for tools for botanical authentication and methods for reproducible extraction of bioactive constituents is critical. Such tools, and improved analytical techniques for identifying potentially bioactive constituents in fresh plant material and in concentrated extracts and for detection of hazardous contaminants, are expected to improve the overall quality and safety of botanical dietary supplement ingredients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - MYCOTOXINS
KW - EPHEDRA
KW - ISOFLAVONES
KW - HOODIA
KW - GERMANDER
KW - UNITED States
KW - Botanical ingredients
KW - Ephedra
KW - Hoodia
KW - Isoflavones
KW - Mycotoxins
KW - Teucrium
N1 - Accession Number: 26290143; Rader, Jeanne I. 1; Email Address: Jeanne.Rader@fda.hhs.gov Delmonte, Pierluigi 1 Trucksess, Mary W. 1; Affiliation: 1: Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Sep2007, Vol. 389 Issue 1, p27; Subject Term: DIETARY supplements; Subject Term: MYCOTOXINS; Subject Term: EPHEDRA; Subject Term: ISOFLAVONES; Subject Term: HOODIA; Subject Term: GERMANDER; Subject Term: UNITED States; Author-Supplied Keyword: Botanical ingredients; Author-Supplied Keyword: Ephedra; Author-Supplied Keyword: Hoodia; Author-Supplied Keyword: Isoflavones; Author-Supplied Keyword: Mycotoxins; Author-Supplied Keyword: Teucrium; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 9p; Document Type: Article
L3 - 10.1007/s00216-007-1254-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290143&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dwyer, Johanna T.
AU - Holden, Joanne
AU - Andrews, Karen
AU - Roseland, Janet
AU - Zhao, Cuiwei
AU - Schweitzer, Amy
AU - Perry, Charles R.
AU - Harnly, James
AU - Wolf, Wayne R.
AU - Picciano, Mary Frances
AU - Fisher, Kenneth D.
AU - Saldanha, Leila G.
AU - Yetley, Elizabeth A.
AU - Betz, Joseph M.
AU - Coates, Paul M.
AU - Milner, John A.
AU - Whitted, Jackie
AU - Burt, Vicki
AU - Radimer, Kathy
AU - Wilger, Jaime
T1 - Measuring vitamins and minerals in dietary supplements for nutrition studies in the USA.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 37
EP - 46
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - This article illustrates the importance of having analytical data on the vitamin and mineral contents of dietary supplements in nutrition studies, and describes efforts to develop an analytically validated dietary supplement ingredient database (DSID) by a consortium of federal agencies in the USA. Preliminary studies of multivitamin mineral supplements marketed in the USA that were analyzed as candidates for the DSID are summarized. Challenges are summarized, possible future directions are outlined, and some related programs at the Office of Dietary Supplements, National Institutes of Health are described. The DSID should be helpful to researchers in assessing relationships between intakes of vitamins and minerals and health outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMINS
KW - DIETARY supplements
KW - NUTRITION
KW - DATABASES
KW - GOVERNMENT agencies
KW - UNITED States. Office of Dietary Supplements
KW - UNITED States
KW - Analytical values
KW - Dietary supplement ingredient database
KW - Dietary supplements
KW - Multivitamin mineral supplements
KW - Multivitamin mineral supplements Analytical values
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 26290159; Dwyer, Johanna T. 1; Email Address: dwyerj1@od.nih.gov Holden, Joanne 2 Andrews, Karen 2 Roseland, Janet 2 Zhao, Cuiwei 2 Schweitzer, Amy 2 Perry, Charles R. 3 Harnly, James 4 Wolf, Wayne R. 4 Picciano, Mary Frances 1 Fisher, Kenneth D. 1 Saldanha, Leila G. 1 Yetley, Elizabeth A. 1 Betz, Joseph M. 1 Coates, Paul M. 1 Milner, John A. 5 Whitted, Jackie 5 Burt, Vicki 6 Radimer, Kathy 6 Wilger, Jaime 6; Affiliation: 1: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA 2: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA 3: Research and Development Division, National Agricultural Statistics Service, US Department of Agriculture, Fairfax, VA 22030, USA 4: Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA 5: Nutritional Sciences Research Group, National Cancer Institute, US Department of Health and Human Services, Bethesda, MD 20892, USA 6: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control and Prevention, US Department of Health and Human Services, Hyattsville, MD 20782, USA; Source Info: Sep2007, Vol. 389 Issue 1, p37; Subject Term: VITAMINS; Subject Term: DIETARY supplements; Subject Term: NUTRITION; Subject Term: DATABASES; Subject Term: GOVERNMENT agencies; Subject Term: UNITED States. Office of Dietary Supplements; Subject Term: UNITED States; Author-Supplied Keyword: Analytical values; Author-Supplied Keyword: Dietary supplement ingredient database; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Multivitamin mineral supplements; Author-Supplied Keyword: Multivitamin mineral supplements Analytical values; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1007/s00216-007-1456-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290159&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delmonte, Pierluigi
AU - Rader, Jeanne I.
T1 - Evaluation of gas chromatographic methods for the determination of trans fat.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 77
EP - 85
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Consumption of trans fat has been associated with increased risk of coronary heart disease. For nutrition labeling purposes, the US Food and Drug Administration (FDA) defines trans fat as the sum of all the fatty acids with at least one nonconjugated double bond in the trans configuration. The FDA regulation states that label declarations of trans fat are not required for products that contain less than 0.5 g of trans fat per serving if no claims are made about fat, fatty acids or cholesterol. While attenuated total reflection Fourier-transformed infrared spectroscopy (ATR-FT-IR) provides reproducible measurements for samples containing more than 5% trans fat, methods based on gas chromatography (GC) are needed to measure lower trans fat levels. Trans fat quantitation by GC has recently been updated by considering more fatty acids, focusing more attention on fatty acids present in low amounts, and by using 100-m high-polarity capillary columns for optimal separation. The consistently high interlaboratory relative standard deviations (RSD, e.g., 21% at 1% trans fatty acids (TFA), 60% at 0.17% TFA), and intralaboratory RSD values (e.g., 10% at 1% TFA, 16% at 0.17% TFA) for trans fat at 1% or less of total fat reported in the collaborative study data for American Oil Chemists Society Official Method Ce 1h-05 suggest the need to carefully define the parameters associated with GC analysis of fatty acids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANS fatty acids
KW - CORONARY heart disease
KW - NUTRITION
KW - FATTY acids
KW - FOURIER transform infrared spectroscopy
KW - UNITED States
KW - Fatty acids
KW - Gas chromatography
KW - Trans fat
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 26290136; Delmonte, Pierluigi 1; Email Address: pierluigi.delmonte@fda.hhs.gov Rader, Jeanne I. 1; Affiliation: 1: US Food and Drug Administration, HFS-717, Room 1E006, 5100 Paint Branch Pkwy, College Park, MD 20740, USA; Source Info: Sep2007, Vol. 389 Issue 1, p77; Subject Term: TRANS fatty acids; Subject Term: CORONARY heart disease; Subject Term: NUTRITION; Subject Term: FATTY acids; Subject Term: FOURIER transform infrared spectroscopy; Subject Term: UNITED States; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Gas chromatography; Author-Supplied Keyword: Trans fat; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1007/s00216-007-1392-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290136&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mossoba, M. M.
AU - Milosevic, V.
AU - Milosevic, M.
AU - Kramer, J. K. G.
AU - Azizian, H.
T1 - Determination of total trans fats and oils by infrared spectroscopy for regulatory compliance.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 87
EP - 92
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - The mandatory requirement in many countries to declare the amount of trans fat present in food products and dietary supplements has led to a need for sensitive and accurate methodologies for the rapid quantitation of total trans fats and oils. Capillary gas chromatography (GC) and infrared spectroscopy (IR) are the two methods most commonly used to identify and quantify trans fatty acids for food labeling purposes (see the article by Delmonte and Rader in this ABC issue for a detailed presentation of GC methodology). The present article provides a comprehensive review of the IR technique and the current attenuated total reflection (ATR) Fourier-transform (FT) IR methodologies for the rapid determination of total trans fats and oils. This review also addresses potential sources of interferences and inaccuracies in FTIR determinations, particularly those done at low trans levels. Recent observations have shown that the presence of saturated fats caused interferences in the FTIR spectra observed for trans triacylglycerols. The recognition and resolution of previously unresolved quantitative issues improved the accuracy and sensitivity of the FTIR methodology. Once validated, it is anticipated that the new negative second-derivative ATR-FTIR procedure will make IR spectroscopy more suitable than ever, and a rapid alternative and/or complementary method to GC, for the rapid determination of total trans fats for regulatory compliance. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FATS & oils
KW - DIETARY supplements
KW - GAS chromatography
KW - INFRARED spectroscopy
KW - TRANS fatty acids
KW - FOURIER transform infrared spectroscopy
KW - Attenuated total reflection
KW - Fourier transform infrared
KW - Trans fats
KW - Validated official methods
N1 - Accession Number: 26290147; Mossoba, M. M. 1; Email Address: magdi.mossoba@fda.hhs.gov Milosevic, V. 2 Milosevic, M. 2 Kramer, J. K. G. 3 Azizian, H. 4; Affiliation: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, Mail Stop HFS-717, Room BE-012, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA 2: MeV Photonics, Westport, CT 06880, USA 3: Agriculture and Agri-Food Canada, Guelph, ON N16 5C9, Canada 4: NIR Technologies, Oakville, ON L6M 2M2, Canada; Source Info: Sep2007, Vol. 389 Issue 1, p87; Subject Term: FATS & oils; Subject Term: DIETARY supplements; Subject Term: GAS chromatography; Subject Term: INFRARED spectroscopy; Subject Term: TRANS fatty acids; Subject Term: FOURIER transform infrared spectroscopy; Author-Supplied Keyword: Attenuated total reflection; Author-Supplied Keyword: Fourier transform infrared; Author-Supplied Keyword: Trans fats; Author-Supplied Keyword: Validated official methods; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1007/s00216-007-1262-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290147&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Capar, Stephen G.
AU - Mindak, William R.
AU - Cheng, John
T1 - Analysis of food for toxic elements.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 159
EP - 169
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - The levels of the toxic elements Al, As, Cd, Hg, Pb and Sn are routinely monitored in food to protect the consumer. Increasingly, the chemical forms of As and Hg are also monitored. Analyses are performed to enforce regulatory standards and to accumulate background levels for assessing long-term exposure. The analytical procedures used for these activities evolve as requirements to determine lower levels arise and as both the types and sheer number of different foods that need to be analyzed increase. This review highlights recent work addressing improvements in the analysis of toxic elements in food. The topics covered include contamination control, analytical sample treatment and the common analytical techniques used for food analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POISONS
KW - CHEMICALS
KW - CONSUMER protection
KW - FOOD -- Analysis
KW - STANDARDS
KW - Analysis
KW - Food
KW - Review
KW - Toxic elements
KW - HARVEY W. Wiley Federal Building (College Park, Md.)
N1 - Accession Number: 26290148; Capar, Stephen G. 1; Email Address: stephen.capar@fda.hhs.gov Mindak, William R. 1 Cheng, John 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W. Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Sep2007, Vol. 389 Issue 1, p159; Subject Term: POISONS; Subject Term: CHEMICALS; Subject Term: CONSUMER protection; Subject Term: FOOD -- Analysis; Subject Term: STANDARDS; Author-Supplied Keyword: Analysis; Author-Supplied Keyword: Food; Author-Supplied Keyword: Review; Author-Supplied Keyword: Toxic elements; Company/Entity: HARVEY W. Wiley Federal Building (College Park, Md.); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1007/s00216-007-1433-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290148&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rimmer, Catherine A.
AU - Howerton, Samuel B.
AU - Sharpless, Katherine E.
AU - Sander, Lane C.
AU - Long, Stephen E.
AU - Murphy, Karen E.
AU - Porter, Barbara J.
AU - Putzbach, Karsten
AU - Rearick, Michael S.
AU - Wise, Stephen A.
AU - Wood, Laura J.
AU - Zeisler, Rolf
AU - Hancock, Diane K.
AU - Yen, James H.
AU - Betz, Joseph M.
AU - NguyenPho, Agnes
AU - Lu Yang
AU - Scriver, Christine
AU - Willie, Scott
AU - Sturgeon, Ralph
T1 - Characterization of a suite of ginkgo-containing standard reference materials.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 179
EP - 196
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - A suite of three ginkgo-containing dietary supplement Standard Reference Materials (SRMs) has been issued by the National Institute of Standards and Technology (NIST) with certified values for flavonoid aglycones, ginkgolides, bilobalide, and selected toxic trace elements. The materials represent a range of matrices (i.e., plant, extract, and finished product) that provide different analytical challenges. The constituents have been determined by at least two independent analytical methods with measurements performed by NIST and at least one collaborating laboratory. The methods utilized different extractions, chromatographic separations, modes of detection, and approaches to quantitation. The SRMs are primarily intended for method validation and for use as control materials to support the analysis of dietary supplements and related botanical materials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINKGO
KW - DIETARY supplements
KW - FLAVONOIDS
KW - TRACE elements
KW - UNITED States
KW - Dietary supplements
KW - Ginkgo biloba
KW - Liquid chromatography
KW - Mass spectrometry
KW - Standard reference material
KW - NATIONAL Institute of Standards & Technology (U.S.)
N1 - Accession Number: 26290157; Rimmer, Catherine A. 1; Email Address: Catherine.Rimmer@nist.gov Howerton, Samuel B. 1 Sharpless, Katherine E. 1 Sander, Lane C. 1 Long, Stephen E. 1 Murphy, Karen E. 1 Porter, Barbara J. 1 Putzbach, Karsten 1 Rearick, Michael S. 1 Wise, Stephen A. 1 Wood, Laura J. 1 Zeisler, Rolf 1 Hancock, Diane K. 1 Yen, James H. 1 Betz, Joseph M. 2 NguyenPho, Agnes 3 Lu Yang 4 Scriver, Christine 4 Willie, Scott 4 Sturgeon, Ralph 4; Affiliation: 1: National Institute of Standards and Technology, Gaithersburg, MD 20899-8392, USA 2: National Institutes of Health, Office of Dietary Supplements, Bethesda, MD 20892, USA 3: Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA 4: National Research Council Canada, Ottawa, ON K1A 0R9, Canada; Source Info: Sep2007, Vol. 389 Issue 1, p179; Subject Term: GINKGO; Subject Term: DIETARY supplements; Subject Term: FLAVONOIDS; Subject Term: TRACE elements; Subject Term: UNITED States; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Ginkgo biloba; Author-Supplied Keyword: Liquid chromatography; Author-Supplied Keyword: Mass spectrometry; Author-Supplied Keyword: Standard reference material; Company/Entity: NATIONAL Institute of Standards & Technology (U.S.); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 18p; Illustrations: 1 Diagram, 7 Charts, 6 Graphs; Document Type: Article
L3 - 10.1007/s00216-007-1398-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290157&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andrews, Karen W.
AU - Schweitzer, Amy
AU - Zhao, Cuiwei
AU - Holden, Joanne M.
AU - Roseland, Janet M.
AU - Brandt, Mary
AU - Dwyer, Johanna T.
AU - Picciano, Mary Frances
AU - Saldanha, Leila G.
AU - Fisher, Kenneth D.
AU - Yetley, Elizabeth
AU - Betz, Joseph M.
AU - Douglass, Larry
T1 - The caffeine contents of dietary supplements commonly purchased in the US: analysis of 53 products with caffeine-containing ingredients.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2007/09//
VL - 389
IS - 1
M3 - Article
SP - 231
EP - 239
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - As part of a study initiating the development of an analytically validated Dietary Supplement Ingredient Database (DSID) in the United States (US), a selection of dietary supplement products were analyzed for their caffeine content. Products sold as tablets, caplets, or capsules and listing at least one caffeine-containing ingredient (including botanicals such as guarana, yerba mate, kola nut, and green tea extract) on the label were selected for analysis based on market share information. Two or three lots of each product were purchased and analyzed using high-pressure liquid chromatography (HPLC). Each analytical run included one or two National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) and two products in duplicate. Caffeine intake per serving and per day was calculated using the maximum recommendations on each product label. Laboratory analysis for 53 products showed product means ranging from 1 to 829 mg caffeine/day. For products with a label amount for comparison ( n = 28), 89% ( n = 25) of the products had analytically based caffeine levels/day of between −16% and +16% of the claimed levels. Lot-to-lot variability ( n = 2 or 3) for caffeine in most products (72%) was less than 10%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - CAFFEINE
KW - HIGH performance liquid chromatography
KW - DATABASES
KW - UNITED States
KW - Caffeine
KW - Dietary supplement
KW - HPLC
KW - Reference material
KW - UV/VIS
KW - NATIONAL Institute of Standards & Technology (U.S.)
N1 - Accession Number: 26290151; Andrews, Karen W. 1; Email Address: karen.andrews@ars.usda.gov Schweitzer, Amy 1 Zhao, Cuiwei 1 Holden, Joanne M. 1 Roseland, Janet M. 1 Brandt, Mary 2 Dwyer, Johanna T. 3 Picciano, Mary Frances 3 Saldanha, Leila G. 3 Fisher, Kenneth D. 3 Yetley, Elizabeth 3 Betz, Joseph M. 3 Douglass, Larry 4; Affiliation: 1: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, USA 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA 3: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA 4: Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA; Source Info: Sep2007, Vol. 389 Issue 1, p231; Subject Term: DIETARY supplements; Subject Term: CAFFEINE; Subject Term: HIGH performance liquid chromatography; Subject Term: DATABASES; Subject Term: UNITED States; Author-Supplied Keyword: Caffeine; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Reference material; Author-Supplied Keyword: UV/VIS; Company/Entity: NATIONAL Institute of Standards & Technology (U.S.); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 9p; Illustrations: 6 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00216-007-1437-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26290151&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Sullivan, P.A.
AU - Robinson, C.F.
AU - Walker, J.T.
T1 - Occupational Risk Factors for Lung Cancer among U. S. Women
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2007/09//
VL - 17
IS - 9
M3 - Abstract
SP - 724
EP - 725
SN - 10472797
AB - Purpose: Lung cancer accounts for 29% of cancer deaths among U.S. women, i.e., 162,460 estimated deaths in 2006. Between 2–20% of lung cancer deaths in women are estimated to be due to classic industrial lung carcinogens, or workplace exposure to side-stream smoke or radon. There are a limited number of studies of occupational lung cancer in women. Our aim was to identify occupations and industries with elevated proportionate lung cancer mortality among working women, and to focus attention on preventable occupational risk factors for lung cancer. Methods: We reviewed the scientific literature on risk factors for occupational lung cancer in women, and undertook a race-specific proportionate mortality (PMR) analysis of nearly 4 million deaths among women who died from 1984–1998 in the 28 U.S. states that code industry sector and occupation on death certificates. Results: Industries with significantly elevated proportionate mortality ratios (PMRs) accounting for the largest number of lung cancer deaths among white working women during the 15-year period were eating and drinking places (PMR=136; n=7783 deaths), hotels and motels (PMR=135; n=1422), several wholesale and retail trades (PMRs range 126–145; n=1405 deaths), several manufacturing sub-sectors (PMRs range 126–142; n=2108), real estate (PMR=137; n=1863), and construction (PMR=125; n=940). Industries accounting for excess lung cancer deaths among white and black women were entertainment and recreation services (PMR=136 white women, PMR=143 black women; n=1209), beauty and barber shops (PMR=124 white women, PMR=122 black women; n=2274), and among black women, public administration (PMR=147; n=718). Focusing on occupation, our analysis revealed significant excess proportionate lung cancer mortality among white women working as waitresses (PMR=152), in sales (PMR=139), as legislative and public administrators (PMR=130), and as managers or administrators (PMR=130). Among black women, financial officers (PMR=175) and receptionists (PMR=183) also experienced excess lung cancer deaths. Conclusion: Women experience significant excess lung cancer mortality associated with occupation. Review of potential exposures in the occupations and industry sectors with elevated lung cancer PMRs suggested several potential lung carcinogens. Workplace exposure to cigarette smoke is a risk factor in some of these industries and occupations, e.g., occupations in the hospitality industry. Other possible explanatory factors in some work environments include a number of known occupational carcinogens. Our findings suggest a need for additional research on occupational risk factors for lung cancer among women working in a wide range of industrial and white collar settings. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Cancer
KW - CANCER -- Risk factors
KW - HEALTH risk assessment
KW - WOMEN -- United States
N1 - Accession Number: 26335950; Sullivan, P.A. 1 Robinson, C.F. 1 Walker, J.T. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV; Source Info: Sep2007, Vol. 17 Issue 9, p724; Subject Term: LUNGS -- Cancer; Subject Term: CANCER -- Risk factors; Subject Term: HEALTH risk assessment; Subject Term: WOMEN -- United States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.annepidem.2007.07.010
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Violanti, J.
AU - Fekedulegn, D.
AU - Andrew, M.
AU - Charles, L.
AU - Hartley, T.
AU - Burchfiel, C.
T1 - Adiposity and Depressive Symptoms in Police Officers
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2007/09//
VL - 17
IS - 9
M3 - Abstract
SP - 734
EP - 734
SN - 10472797
AB - Purpose: To determine the association between measures of adiposity and depression in a sample of police officers. Methods: This study was a cross sectional observational study of 115 police officers stratified by gender and selected at random from an urban police department. Measures of adiposity (Body Mass Index (BMI), abdominal height, and waist circumference) and depressive symptoms (Center for Epidemiological Studies Depression (CES-D) scale) were obtained during a clinic visit. One hundred and three officers (61 men and 42 women) had complete data and linear regression analysis was conducted separately for men and women. Covariate adjustments were made for age, alcohol use, years of police service, smoking, physical activity, fasting serum glucose, and marital status. Results: We found statistically significant positive associations between the CES-D score and both BMI (p = 0.005) and abdominal height (p = 0.006) for men. No significant associations were found between CES-D score and adiposity in women (p =0.591 for BMI, p = 0.81 for abdominal height, p = 0.52 for waist circumference). Adjustment for covariates did not result in any meaningful change in the reported associations. Conclusion: Results indicate a significant positive association between adiposity and depression among male police officers. The temporal sequence and additional physiological and psychological factors that might influence this association should be examined prospectively. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY
KW - POLICE
KW - MENTAL depression
KW - DEPRESSED persons
N1 - Accession Number: 26335979; Violanti, J. 1 Fekedulegn, D. 2 Andrew, M. 2 Charles, L. 2 Hartley, T. 2 Burchfiel, C. 2; Affiliation: 1: Social & Preventive Medicine, SUNY at Buffalo, NY 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, WV; Source Info: Sep2007, Vol. 17 Issue 9, p734; Subject Term: OBESITY; Subject Term: POLICE; Subject Term: MENTAL depression; Subject Term: DEPRESSED persons; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 912130 Provincial police services; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 922120 Police Protection; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.annepidem.2007.07.037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Ana Luisa V.
AU - Oliver, James D.
AU - Depaola, Angelo
AU - Feil, Edward J.
AU - Boyd, E. Fidelma
T1 - Emergence of a Virulent Clade of Vibrio vulnificus and Correlation with the Presence of a 33-Kilobase Genomic Island.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/09//
VL - 73
IS - 17
M3 - Article
SP - 5553
EP - 5565
SN - 00992240
AB - Vibrio vulnificus is a ubiquitous inhabitant of the marine coastal environment, and an important pathogen of humans. We characterized a globally distributed sample of environmental isolates from a range of habitats and hosts and compared these with isolates recovered from cases of human infection. Multilocus sequence typing data using six housekeeping genes divided 63 of the 67 isolates into the two main lineages previously noted for this species, and this division was also confirmed using the 16S rRNA and open reading frame VV0401 markers. Lineage I was comprised exclusively of biotype 1 isolates, whereas lineage 11 contained biotype 1 and all biotype 2 isolates. Four isolates did not cluster within either lineage: two biotype 3 and two biotype 1 isolates. The proportion of isolates recovered from a clinical setting was noted to be higher in lineage I than in lineage II. Lineage I isolates were also associated with a 33-kb genomic island (region XH), one of three regions identified by genome comparisons as unique to the species. Region XII contained an arylsulfatase gene cluster, a sulfate reduction system, two chondroitinase genes, and an oligopeptide ABC transport system, all of which are absent from the majority of lineage H isolates. Arylsulfatases and the sulfate reduction system, along with performing a scavenging role, have been hypothesized to play a role in pathogenic processes in other bacteria. Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO vulnificus
KW - FUNGUS-bacterium relationships
KW - MARINE sciences
KW - SPECIES
KW - SPECIES diversity
KW - GENETICS
KW - VIBRIO parahaemolyticus
KW - AQUATIC animals
KW - AQUATIC ecology
N1 - Accession Number: 26609915; Cohen, Ana Luisa V. 1,2 Oliver, James D. 3 Depaola, Angelo 4 Feil, Edward J. 5 Boyd, E. Fidelma 1; Email Address: fboyd@udel.edu; Affiliation: 1: Department of Biological Sciences, University of Delaware, Newark, Delaware 197161. 2: Department of Microbiology National University of Ireland, Cork ,Ireland. 3: Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223. 4: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528. 5: Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.; Source Info: Sep2007, Vol. 73 Issue 17, p5553; Subject Term: VIBRIO vulnificus; Subject Term: FUNGUS-bacterium relationships; Subject Term: MARINE sciences; Subject Term: SPECIES; Subject Term: SPECIES diversity; Subject Term: GENETICS; Subject Term: VIBRIO parahaemolyticus; Subject Term: AQUATIC animals; Subject Term: AQUATIC ecology; Number of Pages: 13p; Document Type: Article
L3 - 10.1128/AEM.00635-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26609915&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Ana Luisa V.
AU - Oliver, James D.
AU - Depaola, Angelo
AU - Feil, Edward J.
AU - Boyd, E. Fidelma
T1 - Emergence of a Virulent Clade of Vibrio vulnificus and Correlation with the Presence of a 33-Kilobase Genomic Island.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/09//
VL - 73
IS - 17
M3 - Article
SP - 5553
EP - 5565
SN - 00992240
AB - Vibrio vulnificus is a ubiquitous inhabitant of the marine coastal environment, and an important pathogen of humans. We characterized a globally distributed sample of environmental isolates from a range of habitats and hosts and compared these with isolates recovered from cases of human infection. Multilocus sequence typing data using six housekeeping genes divided 63 of the 67 isolates into the two main lineages previously noted for this species, and this division was also confirmed using the 16S rRNA and open reading frame VV0401 markers. Lineage I was comprised exclusively of biotype 1 isolates, whereas lineage 11 contained biotype 1 and all biotype 2 isolates. Four isolates did not cluster within either lineage: two biotype 3 and two biotype 1 isolates. The proportion of isolates recovered from a clinical setting was noted to be higher in lineage I than in lineage II. Lineage I isolates were also associated with a 33-kb genomic island (region XH), one of three regions identified by genome comparisons as unique to the species. Region XII contained an arylsulfatase gene cluster, a sulfate reduction system, two chondroitinase genes, and an oligopeptide ABC transport system, all of which are absent from the majority of lineage H isolates. Arylsulfatases and the sulfate reduction system, along with performing a scavenging role, have been hypothesized to play a role in pathogenic processes in other bacteria. Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungus-bacterium relationships
KW - Marine sciences
KW - Species
KW - Species diversity
KW - Genetics
KW - Aquatic animals
KW - Aquatic ecology
KW - Vibrio vulnificus
KW - Vibrio parahaemolyticus
N1 - Accession Number: 26609915; Cohen, Ana Luisa V. 1,2; Oliver, James D. 3; Depaola, Angelo 4; Feil, Edward J. 5; Boyd, E. Fidelma 1; Email Address: fboyd@udel.edu; Affiliations: 1: Department of Biological Sciences, University of Delaware, Newark, Delaware 197161.; 2: Department of Microbiology National University of Ireland, Cork ,Ireland.; 3: Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223.; 4: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528.; 5: Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.; Issue Info: Sep2007, Vol. 73 Issue 17, p5553; Thesaurus Term: Fungus-bacterium relationships; Thesaurus Term: Marine sciences; Thesaurus Term: Species; Thesaurus Term: Species diversity; Thesaurus Term: Genetics; Thesaurus Term: Aquatic animals; Thesaurus Term: Aquatic ecology; Subject Term: Vibrio vulnificus; Subject Term: Vibrio parahaemolyticus; Number of Pages: 13p; Document Type: Article
L3 - 10.1128/AEM.00635-07
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Clancy, Carolyn M.
AU - Slutsky, Jean R.
T1 - Guidelines for Guidelines: We've Come a Long Way.
JO - CHEST
JF - CHEST
Y1 - 2007/09//
VL - 132
IS - 3
M3 - Article
SP - 746
EP - 747
SN - 00123692
AB - The article discusses the approach of the American College of Chest Physicians (ACCP) in developing clinical practice guidelines. It cites that it this is done by ACCP through managing conflicts of interest to provide clear direction for developer and users and assessing and distilling the continued evolution of science. It also manifested on keeping the guidelines updated which is significant to their acceptance by clinicians and to give a mechanism for getting research findings into practice.
KW - MEDICINE -- Practice
KW - GUIDELINES
KW - CLINICAL medicine
KW - MEDICAL sciences
KW - AMERICAN College of Chest Physicians
N1 - Accession Number: 26972368; Clancy, Carolyn M. 1,2 Slutsky, Jean R. 3,4; Email Address: jean.slutsky@ahrq.hhs.gov; Affiliation: 1: Director, Agency for Healthcare Research and Quality, Center for Outcomes and Research, Agency for Healthcare Research and Quality 2: Director, Center for Outcomes and Research, Agency for Healthcare Research and Quality 3: Vice-Chair of the Executive Board of the Guidelines International Network 4: Member of the Executive Board of the Guidelines International Network; Source Info: Sep2007, Vol. 132 Issue 3, p746; Subject Term: MEDICINE -- Practice; Subject Term: GUIDELINES; Subject Term: CLINICAL medicine; Subject Term: MEDICAL sciences; Company/Entity: AMERICAN College of Chest Physicians; Number of Pages: 2p; Document Type: Article
L3 - 10.1378/chest.07-1727
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, A. M.
AU - Amin, H. S.
AU - Biagini, R. E.
AU - Hamilton, R. G.
AU - Arif, S. A. M.
AU - Yeang, H. Y.
AU - Bernstein, D. I.
T1 - Percutaneous reactivity to natural rubber latex proteins persists in health-care workers following avoidance of natural rubber latex.
JO - Clinical & Experimental Allergy
JF - Clinical & Experimental Allergy
Y1 - 2007/09//
VL - 37
IS - 9
M3 - Article
SP - 1349
EP - 1356
PB - Wiley-Blackwell
SN - 09547894
AB - Background Long-term avoidance of natural rubber latex [ Hevea brasiliensis (Hev b)] is currently recommended for health-care workers (HCWs) with established natural rubber latex (NRL) allergy. Percutaneous sensitivity to eight Hev b NRL allergens was evaluated in HCWs in 2000. To date, no studies have evaluated the longitudinal effects of NRL avoidance on percutaneous sensitivity to NRL allergens. Objective The aims of this study were to evaluate changes in percutaneous reactivity to non-ammoniated latex (NAL) and NRL allergens in HCWs 5 years after a recommendation to avoid NRL and to evaluate factors that predict the persistence of in vivo sensitivity to NAL and NRL allergens. Methods Skin prick testing was performed with NAL, seven NRL allergens (Hev b 1, 2, 3, 4, 6.01, 7.01, and 13), and recombinant Hev b 5 (rHev b 5) in 34 HCWs who were initially evaluated in 2000 for occupationally related NRL allergy. Serial 10-fold dilutions of NAL and NRL allergens were employed in skin testing. Sera from the HCWs were assayed for latex and enhanced latex (rHev b 5-enriched allergosorbent)-specific IgE antibodies using the ImmunoCAP® assay. Results The prevalence of work-related symptoms significantly decreased between 2000 and 2005 with avoidance of NRL ( P<0.05). A ⩾100-fold reduction in percutaneous sensitivity to Hev b 2 and Hev b 7 was less likely in those with prior history of systemic reactions to NRL ( P=0.0053), reported history of reaction to cross-reactive foods ( P=0.014), continued local reactions to NRL gloves ( P<0.0001), or high NRL glove exposure since the initial study ( P=0.0075). The diagnostic sensitivity and specificity of the latex-specific IgE serology was 54% and 87.5%, respectively, in comparison with NAL skin tests. The addition of rHev b 5 to the ImmunoCAP® (enhanced latex) allergosorbent altered the diagnostic sensitivity and specificity of the ImmunoCAP® to 77% and 75%, respectively. Conclusion While symptoms may resolve quickly with NRL avoidance therapy, detectable IgE indicating continued sensitization remains beyond 5 years, and thus continued avoidance of NRL should be recommended. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Hevea
KW - Allergens
KW - Latex
KW - Medical personnel
KW - Skin tests
KW - Rubber
KW - health-care workers
KW - Hev b
KW - latex
KW - latex allergy
KW - natural rubber latex
KW - skin prick test
N1 - Accession Number: 26438558; Smith, A. M. 1; Email Address: sa6@email.uc.edu; Amin, H. S. 1; Biagini, R. E. 2; Hamilton, R. G. 3; Arif, S. A. M. 4; Yeang, H. Y. 4; Bernstein, D. I. 1; Affiliations: 1: Department of Internal Medicine, Division of Allergy/Immunology, University of Cincinnati, Cincinnati, OH, USA; 2: Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA; 3: Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 4: Biotechnology and Strategic Research Unit, Rubber Research Institute of Malaysia, Malaysian Rubber Board, Kuala Lumpur, Malaysia; Issue Info: Sep2007, Vol. 37 Issue 9, p1349; Thesaurus Term: Allergy; Thesaurus Term: Hevea; Thesaurus Term: Allergens; Subject Term: Latex; Subject Term: Medical personnel; Subject Term: Skin tests; Subject Term: Rubber; Author-Supplied Keyword: health-care workers; Author-Supplied Keyword: Hev b; Author-Supplied Keyword: latex; Author-Supplied Keyword: latex allergy; Author-Supplied Keyword: natural rubber latex; Author-Supplied Keyword: skin prick test; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 326291 Rubber Product Manufacturing for Mechanical Use; NAICS/Industry Codes: 325210 Resin and synthetic rubber manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2222.2007.02787.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sunenshine, Rebecca H.
AU - Tan, Esther T.
AU - Terashita, Dawn M.
AU - Jensen, Bette J.
AU - Kacica, Marilyn A.
AU - Sickbert-Bennett, Emily E.
AU - Noble-Wang, Judith A.
AU - Palmieri, Michael J.
AU - Bopp, Dianna J.
AU - Jernigan, Daniel B.
AU - Kazakova, Sophia
AU - Bresnitz, Eddy A.
AU - Tan, Christina G.
AU - McDonald, L. Clifford
T1 - A Multistate Outbreak of Serratia marcescens Bloodstream Infection Associated with Contaminated Intravenous Magnesium Sulfate from a Compounding Pharmacy.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/09//9/1/2007
VL - 45
IS - 5
M3 - Article
SP - 527
EP - 533
SN - 10584838
AB - Background. In contrast to pharmaceutical manufacturers, compounding pharmacies adhere to different quality-control standards, which may increase the likelihood of undetected outbreaks. In 2005, the Centers for Disease Control and Prevention received reports of cases of Serratia marcescens bloodstream infection occurring in patients who underwent cardiac surgical procedures in Los Angeles, California, and in New Jersey. An investigation was initiated to determine whether there was a common underlying cause. Methods. A matched case-control study was conducted in Los Angeles. Case record review and environmental testing were conducted in New Jersey. The Centers for Disease Control and Prevention performed a multistate case-finding investigation; isolates were compared using pulsed-field gel electrophoresis analysis. Results. Nationally distributed magnesium sulfate solution (MgSO4) from compounding pharmacy X was the only significant risk factor for S. marcescens bloodstream infection (odds ratio, 6.4; 95% confidence interval, 1.1-38.3) among 6 Los Angeles case patients and 18 control subjects. Five New Jersey case patients received MgSO4 from a single lot produced by compounding pharmacy X; culture of samples from open and unopened 50-mL bags in this lot yielded S. marcescens. Seven additional case patients from 3 different states were identified. Isolates from all 18 case patients and from samples of MgSO4 demonstrated indistinguishable pulsed-field gel electrophoresis patterns. Compounding pharmacy X voluntarily recalled the product. Neither the pharmacy nor the US Food and Drug Administration could identify a source of contamination in their investigations of compounding pharmacy X. Conclusions. A multistate outbreak of S. marcescens bloodstream infection was linked to contaminated MgSO4 distributed nationally by a compounding pharmacy. Health care personnel should take into account the different quality standards and regulation of compounded parenteral medications distributed in large quantities during investigations of outbreaks of bloodstream infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnesium sulfate
KW - Quality control
KW - Parenteral therapy
KW - Administration of drugs
KW - Cardiac surgery -- Complications
KW - Serratia marcescens
KW - Pulsed-field gel electrophoresis
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 26646514; Sunenshine, Rebecca H. 1; Email Address: Sunensr@azdhs.gov; Tan, Esther T. 1,2; Terashita, Dawn M. 3; Jensen, Bette J. 1; Kacica, Marilyn A. 4; Sickbert-Bennett, Emily E. 5; Noble-Wang, Judith A. 1; Palmieri, Michael J. 6; Bopp, Dianna J. 7; Jernigan, Daniel B. 1; Kazakova, Sophia 1; Bresnitz, Eddy A. 2; Tan, Christina G. 2; McDonald, L. Clifford 1; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, Georgia; 2: New Jersey Department of Health and Senior Services, Trenton, New Jersey; 3: Los Angeles County Department of Health Services, Los Angeles, California; 4: New York State Department of Health; 5: University of North Carolina, Chapel Hill; 6: Food and Drug Administration Northeast Regional Laboratory, Jamaica, New York; 7: New York State Department of Health Wadsworth Laboratory, Albany; Issue Info: 9/1/2007, Vol. 45 Issue 5, p527; Thesaurus Term: Magnesium sulfate; Subject Term: Quality control; Subject Term: Parenteral therapy; Subject Term: Administration of drugs; Subject Term: Cardiac surgery -- Complications; Subject Term: Serratia marcescens; Subject Term: Pulsed-field gel electrophoresis; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; Number of Pages: 7p; Document Type: Article
L3 - 10.1086/520664
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105875488
T1 - Feedback on snake bite: a small puncture can create a large problem...Horn P, Popp JE, Dimitris KD, Ruth B. Snake bite: a small puncture can create a large problem. Consultant for pediatricians. 2007;6:297-302
AU - Wittkamp M
AU - Weinstein SA
AU - Horn P
Y1 - 2007/09//
N1 - Accession Number: 105875488. Language: English. Entry Date: 20080404. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter; pictorial; response. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 750110.
KW - Snake Bites -- Therapy
KW - Adult
KW - Child
KW - Male
KW - Reptiles -- Classification
SP - 878
EP - 880
JO - Consultant (00107069)
JF - Consultant (00107069)
JA - CONSULTANT
VL - 47
IS - 10
CY - Framingham, Massachusetts
PB - United Business Media
SN - 0010-7069
AD - Department of Pediatrics, Chinle Comprehensive Health Care Facility, Indian Health Service, Chinle, Ariz.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhang, Hongmin
AU - Chen, Shiwei
AU - Deng, Xifang
AU - Yang, Xuguang
AU - Huang, Xi
T1 - The effects of Danggui-Buxue-Tang on blood lipid and expression of genes related to foam cell formation in the early stage of atherosclerosis in diabetic GK rats
JO - Diabetes Research & Clinical Practice
JF - Diabetes Research & Clinical Practice
Y1 - 2007/09//
VL - 77
IS - 3
M3 - Article
SP - 479
EP - 481
SN - 01688227
AB - Abstract: Danggui-Buxue-Tang (DBT) is a famous traditional Chinese formula. We determined the effects of DBT on blood lipid and expression of genes related to foam cell formation in the early stage of atherosclerosis in diabetic GK rats. DBT (3 or 6g/kg/day for 4 weeks) was orally administrated to the diabetic atherosclerosis rats, which were induced by nitric oxide inhibition (l-NAME in drinking water, 1mg/ml) plus high-fat diet. The total cholesterol (TC), triglyeride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and the mRNAs expression of monocyte chemoattractant protein (MCP)-1, intercellular adhesion molecule (ICAM)-1 and CD36 mRNA in aorta were determined. The results demonstrated that DBT could regulate blood lipid, inhibit the genes expression of MCP-1, ICAM-1 and CD36 in aorta. [Copyright &y& Elsevier]
AB - Copyright of Diabetes Research & Clinical Practice is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOPENTENOIDS
KW - STEROLS
KW - BLOOD lipids
KW - ATHEROSCLEROSIS
KW - Blood lipid
KW - CD36
KW - Danggui-Buxue-Tang
KW - Diabetic atherosclerosis
KW - Intercellular adhesion molecule-1
KW - Monocyte chemoattractant protein-1
N1 - Accession Number: 26148199; Zhang, Hongmin 1 Chen, Shiwei 2 Deng, Xifang 3 Yang, Xuguang 3 Huang, Xi 1; Email Address: TCMHX@163.com; Affiliation: 1: Laboratory of Ethnopharmacology and Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China 2: Henan Province Food and Drug Administration, Zhengzhou 450012, PR China 3: Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China; Source Info: Sep2007, Vol. 77 Issue 3, p479; Subject Term: ISOPENTENOIDS; Subject Term: STEROLS; Subject Term: BLOOD lipids; Subject Term: ATHEROSCLEROSIS; Author-Supplied Keyword: Blood lipid; Author-Supplied Keyword: CD36; Author-Supplied Keyword: Danggui-Buxue-Tang; Author-Supplied Keyword: Diabetic atherosclerosis; Author-Supplied Keyword: Intercellular adhesion molecule-1; Author-Supplied Keyword: Monocyte chemoattractant protein-1; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.diabres.2006.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26148199&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY -
AU - Lesko, Lawrence J.1, Lawrence.Lesko@fda.hhs.gov
T1 - A Regulatory Perspective on Validation of Surrogate Endpoints.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/09//
Y1 - 2007/09//
VL - 41
IS - 5
CP - 5
M3 - Article
SP - 587
EP - 594
SN - 00928615
AB - The use of biomarkers as surrogate endpoints has had a dramatic and powerful impact on health care and the development and accessibility of drugs. For example, cholesterol is a biomarker used in many clinical trials of cardiovascular drugs such as "statins" where cholesterol reduction is used as a surrogate endpoint for reduced mortality. Although much progress had already been made over the past 20 years--especially in terms of the very real benefits surrogate endpoints have made to efficient medical product development and patient care--the industry faces a host of future challenges as the use of biomarkers and surrogate endpoints play a more integral role in the advancement of new medicines along the critical path of drug development. During the 41st DIA Annual Meeting in Washington, DC, Dr. Lawrence Lesko from the Office of Clinical Pharmacology at the Food and Drug Administration presented a discussion on the challenges associated with the validation of surrogate endpoints, highlighting progress to date as well as future objectives. [ABSTRACT FROM AUTHOR]
KW - Clinical drug trials
KW - Drug development
KW - Biochemical markers
KW - Clinical trials
KW - Medical experimentation on humans
KW - Chemicals -- Physiological effect
KW - Biomarkers
KW - FDA
KW - Surrogate endpoints
N1 - Accession Number: 26652960; Authors: Lesko, Lawrence J. 1 Email Address: Lawrence.Lesko@fda.hhs.gov; Affiliations: 1: Director of the Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Subject: Clinical drug trials; Subject: Drug development; Subject: Biochemical markers; Subject: Clinical trials; Subject: Medical experimentation on humans; Subject: Chemicals -- Physiological effect; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Surrogate endpoints; Number of Pages: 8p; Illustrations: 2 Diagrams, 1 Chart, 1 Graph; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY -
AU - Ling Chen1, ling.chen@fda.hhs.gov
T1 - A Statistician's Viewpoint of Responders in the Treatment of Neuropathic Pain.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/09//
Y1 - 2007/09//
VL - 41
IS - 5
CP - 5
M3 - Article
SP - 685
EP - 689
SN - 00928615
AB - In many clinical studies, the efficacy of a new drug is measured by the mean difference in primary endpoint between the new drug and an active control drug or between the new drug and the placebo. Clinicians sometimes do not believe that the mean difference in primary endpoint between two treatments is clinically meaningful for some drug indications, such as a drug for neuropathic pain associated with diabetic peripheral neuropathy. They prefer to investigate the difference between responder rates. The responder for a treatment for neuropathic pain is defined as a patient who experiences a specific level, often at least 50% in pain reduction from baseline. In this article, the disadvantages of using such a definition are discussed. Some new ideas of defining a responder are proposed. This is illustrated with a real data example. Learning Objectives Upon completion of this article, participants should be able to • Describe the importance of a criterion for the definition ofa responder in responder analysis • Discuss the disadvantages of a current definition ofresponders used in diabetic peripheral neuropathy (DPN) clinical trials • Discuss some possible improvements in defining a responder in responder analysis Target Audience This article is designed for clinicians who are interested in responder analysis. [ABSTRACT FROM AUTHOR]
KW - Medical research
KW - Clinical trials
KW - Medical experimentation on humans
KW - Alternative medicine
KW - Diabetes
KW - Pain
KW - Diabetic peripheral neuropathy
KW - Neuropathy pain
KW - Responder mean
KW - Responder rate
N1 - Accession Number: 26652970; Authors: Ling Chen 1 Email Address: ling.chen@fda.hhs.gov; Affiliations: 1: Division of Biometrics VI/Office of Biostatistics, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland; Subject: Medical research; Subject: Clinical trials; Subject: Medical experimentation on humans; Subject: Alternative medicine; Subject: Diabetes; Subject: Pain; Author-Supplied Keyword: Diabetic peripheral neuropathy; Author-Supplied Keyword: Neuropathy pain; Author-Supplied Keyword: Responder mean; Author-Supplied Keyword: Responder rate; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Sadique, M. Zia
AU - Edmunds, W. John
AU - Smith, Richard D.
AU - Meerding, William Jan
AU - De Zwart, Onno
AU - Brug, Johannes
AU - Beutels, Philippe
T1 - Precautionary Behavior in Response to Perceived Threat of Pandemic Influenza.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/09//
VL - 13
IS - 9
M3 - Article
SP - 1307
EP - 1313
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Faced with an epidemic of an infectious disease, persons may take precautionary actions to try to reduce their risk. Such actions include avoiding situations that persons perceive to be risky, which can have negative health and economic effects. Therefore, we conducted a population-based survey of persons' precautionary actions in response to a hypothetical influenza pandemic. For the 5 European and 3 Asian regions that had been affected by severe acute respiratory syndrome, the pattern of reported precautionary action was broadly similar across the regions; ≈75% of respondents reported that they would avoid public transportation and 20%-30% would try to stay indoors. Some regional differences were noted; Europeans were more likely than Asians to avoid places of entertainment, and Asians were more likely to avoid seeing physicians. This international survey provides insight into what might be expected during an influenza pandemic. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Communicable diseases
KW - Influenza
KW - SARS (Disease)
KW - Health
KW - Physicians
N1 - Accession Number: 26615166; Sadique, M. Zia 1,2; Email Address: zia.sadique@hpa.org.uk; Edmunds, W. John 1; Smith, Richard D. 3; Meerding, William Jan 4; De Zwart, Onno 4,5; Brug, Johannes 4; Beutels, Philippe 6; Affiliations: 1: Health Protection Agency, London, United Kingdom; 2: City University, London, United Kingdom; 3: London School of Hygiene and Tropical Medicine, London, United Kingdom; 4: University Medical Centre, Rotterdam, Netherlands; 5: Municipal Public Health Service, Rotterdam, Netherlands; 6: Antwerp University, Antwerp, Belgium; Issue Info: Sep2007, Vol. 13 Issue 9, p1307; Thesaurus Term: Epidemics; Thesaurus Term: Communicable diseases; Thesaurus Term: Influenza; Thesaurus Term: SARS (Disease); Thesaurus Term: Health; Subject Term: Physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Catsburg, Arnold
AU - Van Dommelen, Laura
AU - Smelov, Vitaly
AU - De Vries, Henry J. C.
AU - Savitcheva, Alevtina
AU - Domeika, Marius
AU - Herrmann, Björn
AU - Ouburg, Sander
AU - Hoebe, Christian J. P. A.
AU - Nilsson, Anders
AU - Savelkoul, Paul H. M.
AU - Morré, Servaas A.
T1 - TaqMan Assay for Swedish Chlamydia trachomatis Variant.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/09//
VL - 13
IS - 9
M3 - Letter
SP - 1432
EP - 1434
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - A letter to the editor about the TaqMan assay for diagnosing a new variant of Chlamydia trachomatis is presented.
KW - Chlamydia
KW - Letters to the editor
N1 - Accession Number: 26615201; Catsburg, Arnold 1; Van Dommelen, Laura 2; Smelov, Vitaly 3,4; De Vries, Henry J. C. 5,6; Savitcheva, Alevtina 3; Domeika, Marius 7; Herrmann, Björn 8; Ouburg, Sander 1; Hoebe, Christian J. P. A. 9; Nilsson, Anders 8; Savelkoul, Paul H. M. 1; Morré, Servaas A. 1,2,10; Email Address: samorretravel@yahoo.co.uk; Affiliations: 1: VU University Medical Center, Amsterdam, the Netherlands; 2: Academic Hospital Maastricht, Maastricht, the Netherlands; 3: D.O. Ott Research Institute of Obstetrics and Gynaecology, St. Petersburg, Russia; 4: St. Petersburg State University, St. Petersburg, Russia; 5: Health Service Amsterdam, Amsterdam, the Netherlands; 6: University of Amsterdam, Amsterdam, the Netherlands; 7: Uppsala University, Uppsala, Sweden; 8: Uppsala University Hospital, Uppsala, Sweden; 9: South Limburg Public Health Service, Heerlen, the Netherlands; 10: City of Hope and Beckman Research Institute, Duarte, California, USA; Issue Info: Sep2007, Vol. 13 Issue 9, p1432; Thesaurus Term: Chlamydia; Subject Term: Letters to the editor; Number of Pages: 3p; Illustrations: 1 Illustration, 1 Chart; Document Type: Letter
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sprando, R.L.
AU - Collins, T.F.X.
AU - Black, T.
AU - Olejnik, N.
AU - Ramos-Valle, M.
AU - Ruggles, D.
T1 - Acute toxicity of sodium arsenite in a complex food matrix
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2007/09//
VL - 45
IS - 9
M3 - Article
SP - 1606
EP - 1613
SN - 02786915
AB - Abstract: Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0mg/kg As in deionized water (41mg/kg As–water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41mg/kg As–water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41mg/kg As–water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410mg/kg) was administered in HH however, at lower doses (41mg/kg), HH reduced acute As oral toxicity in the female and developing fetus. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SODIUM
KW - CONTROL groups (Research)
KW - RATS
KW - ALKALI metals
KW - LIGHT metals
KW - TOXICITY testing
KW - Complex food matrix
KW - Fetus
KW - Male rat
KW - Non-pregnant female rat
KW - Pregnant female rat
KW - Rat
KW - Sodium arsenite
N1 - Accession Number: 25937149; Sprando, R.L.; Email Address: rsprando@cfsan.fda.gov Collins, T.F.X. 1 Black, T. 1 Olejnik, N. 1 Ramos-Valle, M. 1 Ruggles, D. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Road, Laurel, MD 20708, United States; Source Info: Sep2007, Vol. 45 Issue 9, p1606; Subject Term: SODIUM; Subject Term: CONTROL groups (Research); Subject Term: RATS; Subject Term: ALKALI metals; Subject Term: LIGHT metals; Subject Term: TOXICITY testing; Author-Supplied Keyword: Complex food matrix; Author-Supplied Keyword: Fetus; Author-Supplied Keyword: Male rat; Author-Supplied Keyword: Non-pregnant female rat; Author-Supplied Keyword: Pregnant female rat; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Sodium arsenite; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2007.02.026
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cassidy, K.
AU - Elyashiv-Barad, S.
T1 - US FDA's revised consumption factor for polystyrene used in food-contact applications.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2007/09//
VL - 24
IS - 9
M3 - Article
SP - 1026
EP - 1031
PB - Taylor & Francis Ltd
SN - 0265203X
AB - US FDA's continual effort to evaluate the safety of food-contact materials includes periodically re-examining our established packaging factors, such as consumption and food-type distribution factors. The use of polystyrene in food-contact and disposable food-packaging applications has expanded and is expected to continue to increase in the future. Therefore, it is important to revise the polystyrene consumption factor to account for increases in consumer exposure to substances migrating from styrenic food packaging. The currently used consumption factor for polystyrene is 0.1, which is based on market data collected around 1980. US FDA has revised the polystyrene consumption factor utilizing three different sources of market data. Using consumption and population data, US FDA calculated a new consumption factor of 0.14 for polystyrene. This consumption factor has been further subdivided to allow for the refinement of exposure estimates for uses limited to specific subcategories of polystyrene packaging. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polystyrene
KW - Food -- Packaging
KW - Consumption (Economics)
KW - Commercial policy
KW - Physical distribution of goods
KW - Product safety
KW - Consumer protection
KW - United States
KW - consumption factor
KW - exposure
KW - food-contact polymers
KW - United States. Food & Drug Administration
N1 - Accession Number: 26164959; Cassidy, K. 1; Elyashiv-Barad, S. 1; Email Address: sharon.elyashiv-barad@fda.hhs.gov; Affiliations: 1: Division of Food Contact Notifications, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD 20740, USA; Issue Info: Sep2007, Vol. 24 Issue 9, p1026; Thesaurus Term: Polystyrene; Thesaurus Term: Food -- Packaging; Subject Term: Consumption (Economics); Subject Term: Commercial policy; Subject Term: Physical distribution of goods; Subject Term: Product safety; Subject Term: Consumer protection; Subject: United States; Author-Supplied Keyword: consumption factor; Author-Supplied Keyword: exposure; Author-Supplied Keyword: food-contact polymers ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 326140 Polystyrene Foam Product Manufacturing; Number of Pages: 6p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1080/02652030701313797
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105827656
T1 - Children's eligibility and coverage: recent trends and a look ahead.
AU - Hudson JL
AU - Selden TM
Y1 - 2007/09//Sep/Oct2007
N1 - Accession Number: 105827656. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Child Health Services -- Economics
KW - Economic and Social Security -- Legislation and Jurisprudence
KW - Eligibility Determination -- Trends
KW - Health Care Costs -- Statistics and Numerical Data
KW - Medicaid -- Legislation and Jurisprudence
KW - Child Health Services -- Legislation and Jurisprudence
KW - Child
KW - Economic and Social Security -- Utilization
KW - Eligibility Determination -- Statistics and Numerical Data
KW - Emigration and Immigration
KW - Ethnic Groups
KW - Forecasting
KW - Health Care Costs -- Trends
KW - Income -- Classification
KW - Medicaid -- Utilization
KW - Medically Uninsured -- Statistics and Numerical Data
KW - Socioeconomic Factors
KW - Surveys
KW - United States
KW - Human
SP - w618
EP - 29
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 26
IS - 5
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - We used data from the 1996-2005 Medical Expenditure Panel Survey to track changes in children's public insurance eligibility and coverage. During the 2001-2005 'postexpansion' period, eligibility was approximately constant, while public enrollment increased rapidly and uninsurance declined. Nevertheless, as of 2005, 62 percent of all uninsured children (5.5 million) continued to be eligible but not enrolled. We present detailed estimates of their characteristics by age, income, race/ethnicity, health status, and nativity/citizenship. We also examine the impact of potential changes in SCHIP income thresholds--both an expansion and a rollback--and estimate the number and characteristics of the children potentially affected.
SN - 0278-2715
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. sarar@gwu.edu
U2 - PMID: 17702792.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Buzduga, Valentin
AU - Witters, Donald M.
AU - Casamento, Jon P.
AU - Kainz, Wolfgang
T1 - Testing the Immunity of Active Implantable Medical Devices to CW Magnetic Fields up to 1 MHz by an Immersion Method.
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
Y1 - 2007/09//
VL - 54
IS - 9
M3 - Article
SP - 1679
EP - 1686
SN - 00189294
AB - This paper presents a magnetic-field system and the method developed for testing the immunity of the active implantable medical devices to continuous-wave magnetic fields in the frequency range up to 1 MHz. The system is able to produce magnetic fields of 150 A/rn for frequencies up to 100 kHz and strengths decreasing as 1/f between 100 kHz and 1 MHz, with uniformity of the field within ±2.5% in the volume for tests. To simulate human tissue, the medical device, together with its leads, is placed on a plastic grid in a saline tank that is introduced in the magnetic field of the induction coil. This paper offers an alternative for the injection voltage methods provided in the actual standards for assessing the protection of the implantable medical devices from the effects of the magnetic fields up to 1 MHz. This paper presents the equipment and signals used, the test procedure, and results from the preliminary tests performed at the Food and Drug Administration-Center for Devices and Radiological Health on implantable pacemakers and neurostirnulators. The new system and test method are useful for the EMC research on the implantable medical devices. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Biomedical Engineering is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAGNETIC fields
KW - MAGNETIC induction
KW - IMMUNITY
KW - IMMUNOLOGY
KW - MEDICAL equipment
KW - BIOMEDICAL engineering
KW - INDUCTION coils
KW - ELECTRIC apparatus & appliances
KW - PACEMAKER cells
KW - Electromagnetic compatibility (EMC)
KW - electromagnetic interference (EMI)
KW - implantable biomedical devices
KW - magnetic fields
KW - pacemakers
N1 - Accession Number: 26405195; Buzduga, Valentin 1; Email Address: buzdugav@yahoo.com Witters, Donald M. 2; Email Address: donald.witters@fda.hhs.gov Casamento, Jon P. 2; Email Address: jon.casamento@fda.hhs.gov Kainz, Wolfgang 2; Email Address: wolfgang.kainz@fda.hhs.gov; Affiliation: 1: Scantek, Inc., Columbia, MD 21046 USA 2: Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852 USA; Source Info: Sep2007, Vol. 54 Issue 9, p1679; Subject Term: MAGNETIC fields; Subject Term: MAGNETIC induction; Subject Term: IMMUNITY; Subject Term: IMMUNOLOGY; Subject Term: MEDICAL equipment; Subject Term: BIOMEDICAL engineering; Subject Term: INDUCTION coils; Subject Term: ELECTRIC apparatus & appliances; Subject Term: PACEMAKER cells; Author-Supplied Keyword: Electromagnetic compatibility (EMC); Author-Supplied Keyword: electromagnetic interference (EMI); Author-Supplied Keyword: implantable biomedical devices; Author-Supplied Keyword: magnetic fields; Author-Supplied Keyword: pacemakers; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; NAICS/Industry Codes: 416110 Electrical wiring and construction supplies merchant wholesalers; NAICS/Industry Codes: 335999 All Other Miscellaneous Electrical Equipment and Component Manufacturing; NAICS/Industry Codes: 335990 All other electrical equipment and component manufacturing; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 8p; Illustrations: 3 Black and White Photographs, 13 Charts; Document Type: Article
L3 - 10.1109/TBME.2007.893502
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Listak, J. M.
AU - Reed, W. R.
T1 - Water separator shows potential for reducing respirable dust generated on small-diameter rotary blasthole drills.
JO - International Journal of Mining, Reclamation & Environment
JF - International Journal of Mining, Reclamation & Environment
Y1 - 2007/09//
VL - 21
IS - 3
M3 - Article
SP - 160
EP - 172
SN - 17480930
AB - Drilling with water has the potential to significantly reduce the respirable dust concentrations generated from small-diameter rotary drills when drilling blastholes on surface mining operations. However, water adversely affects tri-cone drill bits commonly used in surface drilling operations, causing excessive wear and premature replacement. Consequently, dry drilling with a dust collector system has the most widespread use in the industry. Tests have been conducted by the National Institute of Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory (PRL) on a newly designed device for smaller diameter drills that separates the water from the bailing air before it reaches the bit and thus provides the cost benefit of dry drilling while providing the benefit of wet drilling for dust suppression. The water that is delivered to the hole with the bailing air is separated from the air by a proprietary mechanical device that is encased in a drill sub (short section of drill rod/pipe) located immediately behind the cutting bit. A cascade cyclone and a real-time dust monitor were used to sample dust emissions from the holes. Dust concentrations and silica content were measured when drilling dry versus drilling wet. The tests show that drilling with this water separating sub can reduce both measured dust emissions from the boreholes and visible dust around the drill rig. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Mining, Reclamation & Environment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR quality
KW - AIR pollution
KW - BORING machinery
KW - DRILLING & boring machinery
KW - EMISSIONS (Air pollution)
KW - STRIP mining
KW - INDUSTRIAL safety
KW - AIR pollution monitoring
KW - EMISSION control
KW - RESEARCH
KW - Respirable dust
KW - Surface drilling
KW - Water separator
KW - Wet drilling
N1 - Accession Number: 25998514; Listak, J. M. 1; Email Address: jlistak@cdc.gov Reed, W. R. 1; Affiliation: 1: Pittsburgh Research Laboratory, Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA; Source Info: Sep2007, Vol. 21 Issue 3, p160; Subject Term: AIR quality; Subject Term: AIR pollution; Subject Term: BORING machinery; Subject Term: DRILLING & boring machinery; Subject Term: EMISSIONS (Air pollution); Subject Term: STRIP mining; Subject Term: INDUSTRIAL safety; Subject Term: AIR pollution monitoring; Subject Term: EMISSION control; Subject Term: RESEARCH; Author-Supplied Keyword: Respirable dust; Author-Supplied Keyword: Surface drilling; Author-Supplied Keyword: Water separator; Author-Supplied Keyword: Wet drilling; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 213115 Support Activities for Nonmetallic Minerals (except Fuels) Mining; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; NAICS/Industry Codes: 213111 Drilling Oil and Gas Wells; NAICS/Industry Codes: 417220 Mining and oil and gas well machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 333132 Oil and Gas Field Machinery and Equipment Manufacturing; NAICS/Industry Codes: 333517 Machine Tool Manufacturing; NAICS/Industry Codes: 532412 Construction, Mining, and Forestry Machinery and Equipment Rental and Leasing; NAICS/Industry Codes: 333130 Mining and oil and gas field machinery manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 212111 Bituminous Coal and Lignite Surface Mining; NAICS/Industry Codes: 212113 Anthracite Mining; Number of Pages: 13p; Illustrations: 4 Black and White Photographs, 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/17480930601176846
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25998514&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Derek R.
T1 - Alcohol and tobacco consumption among Australian police officers: 1989 to 2005.
JO - International Journal of Police Science & Management
JF - International Journal of Police Science & Management
Y1 - 2007/09//
VL - 9
IS - 3
M3 - Article
SP - 274
EP - 286
PB - Sage Publications, Ltd.
SN - 14613557
AB - Lifestyle factors represent a significant occupational health issue for law enforcement personnel around the world. Despite this fact, longitudinal investigations of alcohol and tobacco consumption trends among them are rarely undertaken, particularly on a national basis. The aim of the current study therefore, was to examine the changing nature of high-risk alcohol consumption and tobacco smoking habits among a nationally representative sample of Australian police officers, for what appears to be the first time. Data pertaining to law enforcement personnel were extracted from four National Health Surveys conducted in Australia between 1989 and 2005. A referent group was also formulated for the same time periods. Results from this investigation suggest that the proportion of Australian police who consume alcohol at high rates is slowly declining in recent years. On the other hand, tobacco consumption among them has remained relatively stable, with around one-fifth of Australian police still smoking in 2004–05. Law enforcement is clearly a high-stress occupation when compared with other jobs, and the impact of workplace issues continues to influence lifestyle factors beyond the work environment. This unique facet ensures that alcohol and tobacco consumption will remain an important occupational health issue for police management in future years. As the retention of healthy, experienced law enforcement personnel is essential for the smooth functioning of any police force, additional research and management efforts should focus on the continued reduction of these detrimental lifestyle factors. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Police Science & Management is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LAW enforcement -- Research
KW - POLICE
KW - CRIMINAL justice personnel
KW - SUBSTANCE abuse
KW - TOBACCO
KW - ALCOHOL
KW - EPIDEMIOLOGY
KW - SUBSTANCE use
KW - AUSTRALIA
KW - alcohol
KW - Australia
KW - epidemiology
KW - police
KW - smoking
KW - tobacco
N1 - Accession Number: 26863287; Smith, Derek R. 1; Affiliation: 1: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6–21–1 Nagao, Tama-Ku, Kawasaki 214–8585 Japan. Tel: +81 44 865 6111; Fax: +81 44 865 6124; email:; Source Info: Autumn2007, Vol. 9 Issue 3, p274; Subject Term: LAW enforcement -- Research; Subject Term: POLICE; Subject Term: CRIMINAL justice personnel; Subject Term: SUBSTANCE abuse; Subject Term: TOBACCO; Subject Term: ALCOHOL; Subject Term: EPIDEMIOLOGY; Subject Term: SUBSTANCE use; Subject Term: AUSTRALIA; Author-Supplied Keyword: alcohol; Author-Supplied Keyword: Australia; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: police; Author-Supplied Keyword: smoking; Author-Supplied Keyword: tobacco; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 912130 Provincial police services; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 913130 Municipal police services; Number of Pages: 13p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1350/ijps.2007.9.3.274
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greskevitch, Mark
AU - Kullman, Greg
AU - Ki Moon Bang
AU - Mazurek, Jacek M.
T1 - Respiratory Disease in Agricultural Workers: Mortality and Morbidity Statistics.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/09//
VL - 12
IS - 3
M3 - Article
SP - 5
EP - 10
SN - 1059924X
AB - To quantify the respiratory disease burden among agricultural workers, we examined the 1988-1998 National Center for Health Statistics (NCHS) "Multiple Cause of Death Data" and the 1988-1994 Third National Health and Nutrition Examination Survey data (NHANES III). Proportionate mortality ratios (PMRs) were determined for 11 respiratory conditions among 6 agricultural groups: crop farm workers, livestock farm workers, farm managers, landscape and horticultural workers, forestry workers, and fishery workers. Prevalence ratios (PRs) were determined for 12 respiratory conditions among 3 agricultural groups: farm workers, farm managers, and other agricultural workers. Disease categories groups were based on the 9th International Classification of Diseases and the agricultural groups on the NCHS or NHANES III industry and occupation codes, respectively. Crop farm workers and livestock farm workers had significantly elevated mortality for several respiratory conditions, with mortality for hypersensitivity pneumonitis being 10 and 50 times higher than expected. Landscape and horticultural workers had significantly elevated mortality for abscess of the lung and mediastinum and chronic airways obstruction. Forestry workers had significantly elevated mortality for pulmonary tuberculosis, chronic airways obstruction, and pneumonia. Prevalence of wheeze was elevated for female farm workers, shortness of breath was elevated for farm workers who had ever smoked, and hay fever was elevated for black, non-Hispanic farm workers. Prevalence of asthma was elevated for other agricultural workers who had ever smoked. Farm workers had a PR of 173 for obstructive respiratory abnormality. Continued improvement in occupational health surveillance systems for agriculture is essential to help guide prevention efforts for respiratory disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - AGRICULTURAL laborers
KW - FARMERS
KW - HEALTH surveys -- United States
KW - REPORTING of diseases
KW - MORTALITY
KW - PUBLIC health surveillance
KW - UNITED States
KW - Agriculture
KW - morbidity rates
KW - mortality rates
KW - respiratory system disorders
KW - NATIONAL Center for Health Statistics (U.S.)
N1 - Accession Number: 35272315; Greskevitch, Mark 1; Email Address: mgreskevitch@cdc.gov Kullman, Greg 1 Ki Moon Bang 1 Mazurek, Jacek M. 1; Affiliation: 1: Division of Respiratory Disease Studies (DRDS), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC); Source Info: 2007, Vol. 12 Issue 3, p5; Subject Term: RESPIRATORY diseases; Subject Term: AGRICULTURAL laborers; Subject Term: FARMERS; Subject Term: HEALTH surveys -- United States; Subject Term: REPORTING of diseases; Subject Term: MORTALITY; Subject Term: PUBLIC health surveillance; Subject Term: UNITED States; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: morbidity rates; Author-Supplied Keyword: mortality rates; Author-Supplied Keyword: respiratory system disorders; Company/Entity: NATIONAL Center for Health Statistics (U.S.); NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/10599240701881482
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35272315&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Greskevitch, Mark
AU - Doney, Brent
AU - Groce, Dennis
AU - Syamlal, Girija
AU - Ki Moon Bang
T1 - Respirator Use and Practices in Agricultural Crop Production Establishments.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/09//
VL - 12
IS - 3
M3 - Article
SP - 25
EP - 31
SN - 1059924X
AB - The risk of developing respiratory diseases can be reduced by either wearing respiratory protection under the guidance of an effective respiratory protection program or using controls. In 2001, the Survey of Respirator Use and Practices gathered information on the types of respirators used, respirator use practices, and the respirator program characteristics from 40,002 randomly selected US establishments. This report presents findings of the Survey of Respirator Use and Practices for the Agricultural Production--Crops industry and compares them with National Institute for Occupational Safety and Health (NIOSH) recommendations. Approximately one third of all Agricultural Production--Crops establishments required respirator use. Of the Agricultural Production--Crops establishments that required respirator use, (1) a written program to determine what type of respirator to use was not adopted by management in 73% of the establishments; (2) 21% did not know whether air sampling was conducted for substances for which employees were required to use respirators; (3) 29.5% did not provide respirator training for employees; (4) employees were not assessed for medical fitness to wear a respirator or it was not known whether the employees were assessed, in 49.4%; and (5) the program administrator had received no respirator training in 29.5%. Of the Agricultural Production--Crops establishments that required respirator use, 69.5% had at least 3 indicators of a potentially inadequate respiratory protection program. The high rates of indicators of potential inadequacies suggest widespread problems with respiratory protection programs in the Agricultural Production--Crops industry, indicating a potential for improvement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL safety
KW - RESPIRATORY diseases
KW - INDUSTRIAL management
KW - CROPS
KW - WOUNDS & injuries -- Prevention
KW - AGRICULTURAL systems
KW - SAMPLING (Statistics)
KW - PUBLIC health surveillance
KW - Agriculture
KW - respirators
KW - respiratory system disorders
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 35272317; Greskevitch, Mark 1; Email Address: mgreskevitch@cdc.gov Doney, Brent 1 Groce, Dennis 2 Syamlal, Girija 1 Ki Moon Bang 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Morgantown, WVa. 2: EG&G Technical Services, Inc., Pittsburgh, Penn.; Source Info: 2007, Vol. 12 Issue 3, p25; Subject Term: INDUSTRIAL safety; Subject Term: RESPIRATORY diseases; Subject Term: INDUSTRIAL management; Subject Term: CROPS; Subject Term: WOUNDS & injuries -- Prevention; Subject Term: AGRICULTURAL systems; Subject Term: SAMPLING (Statistics); Subject Term: PUBLIC health surveillance; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: respirators; Author-Supplied Keyword: respiratory system disorders; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/10599240801887801
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35272317&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105705708
T1 - Respiratory disease in agricultural workers: mortality and morbidity statistics.
AU - Greskevitch M
AU - Kullman G
AU - Bang KM
AU - Mazurek JM
Y1 - 2007/09//
N1 - Accession Number: 105705708. Language: English. Entry Date: 20081205. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Farmworkers
KW - Morbidity
KW - Mortality
KW - Respiratory Tract Diseases
KW - Statistics
KW - Adult
KW - Alveolitis, Extrinsic Allergic
KW - Asthma
KW - Female
KW - Lung Diseases, Obstructive
KW - Male
KW - Middle Age
KW - Pneumonia
KW - Respiratory Sounds
KW - Respiratory Tract Diseases -- Prevention and Control
KW - Rhinitis, Allergic, Perennial
KW - Rhinitis, Allergic, Seasonal
KW - Tuberculosis, Pulmonary
KW - United States
KW - Human
SP - 5
EP - 10
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 12
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - To quantify the respiratory disease burden among agricultural workers, we examined the 1988-1998 National Center for Health Statistics (NCHS) 'Multiple Cause of Death Data' and the 1988-1994 Third National Health and Nutrition Examination Survey data (NHANES III). Proportionate mortality ratios (PMRs) were determined for 11 respiratory conditions among 6 agricultural groups: crop farm workers, livestock farm workers, farm managers, landscape and horticultural workers, forestry workers, and fishery workers. Prevalence ratios (PRs) were determined for 12 respiratory conditions among 3 agricultural groups: farm workers, farm managers, and other agricultural workers. Disease categories groups were based on the 9th International Classification of Diseases and the agricultural groups on the NCHS or NHANES III industry and occupation codes, respectively. Crop farm workers and livestock farm workers had significantly elevated mortality for several respiratory conditions, with mortality for hypersensitivity pneumonitis being 10 and 50 times higher than expected. Landscape and horticultural workers had significantly elevated mortality for abscess of the lung and mediastinum and chronic airways obstruction. Forestry workers had significantly elevated mortality for pulmonary tuberculosis, chronic airways obstruction, and pneumonia. Prevalence of wheeze was elevated for female farm workers, shortness of breath was elevated for farm workers who had ever smoked, and hay fever was elevated for black, non-Hispanic farm workers. Prevalence of asthma was elevated for other agricultural workers who had ever smoked. Farm workers had a PR of 173 for obstructive respiratory abnormality. Continued improvement in occupational health surveillance systems for agriculture is essential to help guide prevention efforts for respiratory disease.
SN - 1059-924X
AD - Division of Respiratory Disease Studies (DRDS), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC); mgreskevitch@cdc.gov
U2 - PMID: 19042666.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105705711
T1 - Respirator use and practices in agricultural crop production establishments.
AU - Greskevitch M
AU - Doney B
AU - Groce D
AU - Syamlal G
AU - Bang KM
Y1 - 2007/09//
N1 - Accession Number: 105705711. Language: English. Entry Date: 20081205. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Agriculture
KW - Respiratory Protective Devices -- Utilization
KW - National Institute for Occupational Safety and Health
KW - Questionnaires
KW - Respiratory Protective Devices -- Education
KW - Surveys
KW - Human
SP - 25
EP - 31
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 12
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The risk of developing respiratory diseases can be reduced by either wearing respiratory protection under the guidance of an effective respiratory protection program or using controls. In 2001, the Survey of Respirator Use and Practices gathered information on the types of respirators used, respirator use practices, and the respirator program characteristics from 40,002 randomly selected US establishments. This report presents findings of the Survey of Respirator Use and Practices for the Agricultural Production-Crops industry and compares them with National Institute for Occupational Safety and Health (NIOSH) recommendations. Approximately one third of all Agricultural Production-Crops establishments required respirator use. Of the Agricultural Production-Crops establishments that required respirator use, (1) a written program to determine what type of respirator to use was not adopted by management in 73% of the establishments; (2) 21% did not know whether air sampling was conducted for substances for which employees were required to use respirators; (3) 29.5% did not provide respirator training for employees; (4) employees were not assessed for medical fitness to wear a respirator or it was not known whether the employees were assessed, in 49.4%; and (5) the program administrator had received no respirator training in 29.5%. Of the Agricultural Production-Crops establishments that required respirator use, 69.5% had at least 3 indicators of a potentially inadequate respiratory protection program. The high rates of indicators of potential inadequacies suggest widespread problems with respiratory protection programs in the Agricultural Production-Crops industry, indicating a potential for improvement.
SN - 1059-924X
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road Mail Stop HG-900.2, Morgantown, WV 26505; mgreskevitch@cdc.gov
U2 - PMID: 19042668.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wiesenfeld, Paddy L.
AU - Garthoff, Larry H.
AU - Sobotka, Thomas J.
AU - Suagee, Jessica K.
AU - Barton, Curtis N.
T1 - Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2007/09//Sep/Oct2007
VL - 27
IS - 5
M3 - Article
SP - 421
EP - 433
SN - 0260437X
AB - The article presents the study conducted on the acute oral perniciousness of colchicine (COL) in male and female rats in the U.S. This research evaluates the comparative effects of a simple versus a complex vehicle matrix, gender and pretreatment of animals with lipopolysaccharide (LPS), on COL toxicity. It notes that colchicine is a tropolene alkaloid extracted from the plant Colchicum autumnale, a member of the lily family such as meadow saffron, autumn crocus and gloriosa superba tuber. The entire plant is poisonous specially its bulb because it contains the highest concentration of the toxic chemical which is used in the treatment of human diseases including cancer, due to its anti-mitotic, anti-inflammatory and anti-fibrotic properties.
KW - Colchicine
KW - Toxicity testing
KW - Experimental toxicology
KW - Cancer treatment
KW - Cancer -- Alternative treatment
KW - Nonsteroidal anti-inflammatory agents
KW - Rats as laboratory animals
KW - Saffron crocus
KW - United States
KW - colchicine
KW - Half and Half cream
KW - lethality
KW - lipopolysaccharide
KW - oral
KW - rats
KW - toxicity
N1 - Accession Number: 27712616; Wiesenfeld, Paddy L. 1; Email Address: paddy.wiesenfeld@fda.hhs.gov; Garthoff, Larry H. 1; Sobotka, Thomas J. 1; Suagee, Jessica K. 1; Barton, Curtis N. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology. Neurotoxicity and In Vitro Toxicology Branch, Laurel. MD, USA; Issue Info: Sep/Oct2007, Vol. 27 Issue 5, p421; Thesaurus Term: Colchicine; Thesaurus Term: Toxicity testing; Thesaurus Term: Experimental toxicology; Subject Term: Cancer treatment; Subject Term: Cancer -- Alternative treatment; Subject Term: Nonsteroidal anti-inflammatory agents; Subject Term: Rats as laboratory animals; Subject Term: Saffron crocus; Subject: United States; Author-Supplied Keyword: colchicine; Author-Supplied Keyword: Half and Half cream; Author-Supplied Keyword: lethality; Author-Supplied Keyword: lipopolysaccharide; Author-Supplied Keyword: oral; Author-Supplied Keyword: rats; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1002/jat.1198
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hong, Jee Eun
AU - Pyo, Heesoo
AU - Park, Song-Ja
AU - Lee, Won
T1 - Determination of hydroxy metabolites of polychlorinated biphenyls in plasma and tissue by gas chromatography/mass spectrometry
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2007/09//
VL - 856
IS - 1/2
M3 - Article
SP - 1
EP - 8
SN - 15700232
AB - Abstract: This study examines a novel sample preparation method for the determination of 11 hydroxy metabolites of polychlorinated biphenyls (PCBs) in plasma and organ tissues, followed by gas chromatography with mass spectrometric detection (GC/MS). The clean-up method was optimized to eliminate the interference matter by using a silica column and 10mL of n-hexane/dichloromethane (4:6, v/v) as an eluent. Solid-phase and solvent extraction procedures were used for the plasma and tissues samples, respectively. Compared to C18 and C8 solid-phase, C2 showed higher extraction efficiency with n-hexane as the eluent for plasma. The hydroxy-PCB extraction recoveries achieved with this combined extraction and clean-up procedure from plasma ranged from 87 to 117%, while those from tissues ranged from 82 to 111%. The linear detector responses for propyl derivatives of hydroxy-PCBs were obtained with the coefficients of determination varying from 0.992 to 0.998 in the concentration range of 0.1–20ngmL−1. The method detection limits ranged from 0.1 to 0.5ngmL−1 in 1mL of plasma and from 0.1 to 0.5ngg−1 in 1g of tissues. This procedure was successfully applied to the study of 3-OH-2,3′,4,4′,5-PeCB in rat plasma and liver samples after intraperitoneal injection (20mg/kg) of 2,3′,4,4′,5-PeCB. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIPHENYL compounds
KW - POLYCHLORINATED biphenyls
KW - GAS chromatography
KW - TISSUES
KW - ORGANOCHLORINE compounds
KW - SILICA
KW - BLOOD plasma
KW - LIVER
KW - Clean-up
KW - GC/MS
KW - Hydroxy-PCBs
KW - Plasma
KW - SPE
KW - Tissue
N1 - Accession Number: 26413483; Hong, Jee Eun 1 Pyo, Heesoo 2; Email Address: phs3692@kist.re.kr Park, Song-Ja 2 Lee, Won 3; Affiliation: 1: Gyeongin Regional Korea Food and Drug Administration, Test and Analytical Team, #120 Juan-dong, Nam-Gu, Incheon, South Korea 2: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheogryang, Seoul 136-791, South Korea 3: Department of Chemistry, Kyunghee University, Seoul 130-701, South Korea; Source Info: Sep2007, Vol. 856 Issue 1/2, p1; Subject Term: BIPHENYL compounds; Subject Term: POLYCHLORINATED biphenyls; Subject Term: GAS chromatography; Subject Term: TISSUES; Subject Term: ORGANOCHLORINE compounds; Subject Term: SILICA; Subject Term: BLOOD plasma; Subject Term: LIVER; Author-Supplied Keyword: Clean-up; Author-Supplied Keyword: GC/MS; Author-Supplied Keyword: Hydroxy-PCBs; Author-Supplied Keyword: Plasma; Author-Supplied Keyword: SPE; Author-Supplied Keyword: Tissue; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jchromb.2007.05.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hennessy, Sean
AU - Bilker, Warren B.
AU - Leonard, Charles E.
AU - Chittams, Jesse
AU - Palumbo, Cristin M.
AU - Karlawish, Jason H.
AU - Yang, Yu-Xiao
AU - Lautenbach, Ebbing
AU - Baine, William B.
AU - Metlay, Joshua P.
T1 - Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
Y1 - 2007/09//
VL - 60
IS - 9
M3 - journal article
SP - 911
EP - 918
SN - 08954356
AB - Objective: A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis.Study Design and Setting: Case-control study of persons aged 65 and above nested in the UK General Practice Research Database.Results: We identified 12,044 cases of the hospitalization for pneumonia (the primary outcome) and 48,176 controls. The odds ratio (OR) for any antidepressant use, adjusting for age, sex, and calendar year was 1.61 (95% confidence interval 1.46-1.78). After further adjustment for comorbidity measures, the OR was 0.89 (0.79-1.00). We also identified 159 cases of hospitalization for aspiration pneumonia (the secondary outcome) and 636 controls. The OR for any antidepressant use, adjusted for age, sex, and calendar year was 1.45 (0.65-3.24). After further adjustment for comorbidity measures, the OR was 0.63 (0.23-1.71).Conclusion: These findings refute the prior hypothesis that use of antidepressants by elderly patients increases the risk of hospitalization for pneumonia or for aspiration pneumonia. Decisions regarding use of antidepressants in elderly persons should not be affected by concern about pneumonia risk. Data-derived hypotheses should be independently confirmed before being acted upon. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Epidemiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL epidemiology
KW - PUBLIC health
KW - BIOLOGY
KW - MEDICAL sciences
KW - Aged
KW - Antidepressive agents
KW - aspiration
KW - Confounding factors
KW - Pharmacoepidemiology
KW - Pneumonia
KW - Pneumonia, aspiration
N1 - Accession Number: 26161584; Hennessy, Sean 1,2,3; Email Address: shenness@cceb.med.upenn.edu Bilker, Warren B. 1,2,3 Leonard, Charles E. 1,2,3 Chittams, Jesse 1,2,3 Palumbo, Cristin M. 1,2,3 Karlawish, Jason H. 1,4 Yang, Yu-Xiao 1,3,4 Lautenbach, Ebbing 1,2,3,4 Baine, William B. 5 Metlay, Joshua P. 1,2,3,4,6; Affiliation: 1: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 2: Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 3: Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 4: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 5: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD, USA 6: Department of Veterans Affairs, Philadelphia, PA, USA; Source Info: Sep2007, Vol. 60 Issue 9, p911; Subject Term: CLINICAL epidemiology; Subject Term: PUBLIC health; Subject Term: BIOLOGY; Subject Term: MEDICAL sciences; Author-Supplied Keyword: Aged; Author-Supplied Keyword: Antidepressive agents; Author-Supplied Keyword: aspiration; Author-Supplied Keyword: Confounding factors; Author-Supplied Keyword: Pharmacoepidemiology; Author-Supplied Keyword: Pneumonia; Author-Supplied Keyword: Pneumonia, aspiration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Document Type: journal article
L3 - 10.1016/j.jclinepi.2006.11.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barr, Dana B.
AU - Hines, Cynthia J.
AU - Olsson, Anders O.
AU - Deddens, James A.
AU - Bravo, Roberto
AU - Striley, Cynthia A. F.
AU - Norrgran, Jessica
AU - Needham, Larry L.
T1 - Identification of human urinary metabolites of acetochlor in exposed herbicide applicators by high-performance liquid chromatography-tandem mass spectrometry.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2007/09//
VL - 17
IS - 6
M3 - Article
SP - 559
EP - 566
PB - Nature Publishing Group
SN - 15590631
AB - Acetochlor is a preemergent chloroacetanilide herbicide used to control annual grasses and small-seeded broadleaf weeds. It is the second most abundantly applied herbicide on corn crops in the United States; however, human metabolites associated with known exposure to acetochlor have not been positively identified and confirmed. We positively identified acetochlor mercapturate (ACM) as a metabolite of acetochlor in urine samples collected during a 24-h period from custom (commercial) applicators who had applied acetochlor on either the day of or the day before urine collection. Concentrations in applicator urine samples ranged from 0.5 to 449 μg/l (0.3–121 μg/g creatinine). We found that ACM accounted for as much as 42% of the total acetochlor-derived metabolites; however, as the exposure level decreased (based on total acetochlor metabolite level), ACM became a less abundant metabolite of acetochlor (<17%). Unmetabolized acetochlor was also measured in the urine samples analyzed. At high exposures (classified as >100 μg/l), acetochlor accounted for about 0.8% of the total excreted acetochlor metabolites (∼2% of the ACM concentrations). At lower exposures (classified as ACM <10 μg/l), ACM and acetochlor concentrations were similar. Additionally, we tentatively identified another acetochlor metabolite that appeared to be important at low levels of exposure.Journal of Exposure Science and Environmental Epidemiology (2007) 17, 559–566; doi:10.1038/sj.jes.7500583; published online 30 May 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBICIDES
KW - BIOLOGICAL products
KW - CORN
KW - FORAGE plants
KW - METABOLITES
KW - acetochlor
KW - acetochlor mercapturate
KW - biological monitoring
KW - mass spectrometry
KW - urine
N1 - Accession Number: 26547541; Barr, Dana B. 1; Email Address: dlb1@cdc.gov Hines, Cynthia J. 2 Olsson, Anders O. 1 Deddens, James A. 2,3 Bravo, Roberto 1 Striley, Cynthia A. F. 2 Norrgran, Jessica 1 Needham, Larry L. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia, USA 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA 3: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio, USA; Source Info: Sep2007, Vol. 17 Issue 6, p559; Subject Term: HERBICIDES; Subject Term: BIOLOGICAL products; Subject Term: CORN; Subject Term: FORAGE plants; Subject Term: METABOLITES; Author-Supplied Keyword: acetochlor; Author-Supplied Keyword: acetochlor mercapturate; Author-Supplied Keyword: biological monitoring; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: urine; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 8p; Illustrations: 4 Diagrams, 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/sj.jes.7500583
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Egan, Sara Kathleen
AU - Bolger, Philip Michael
AU - Carrington, Clark Dewitt
T1 - Update of US FDA's Total Diet Study food list and diets.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2007/09//
VL - 17
IS - 6
M3 - Article
SP - 573
EP - 582
PB - Nature Publishing Group
SN - 15590631
AB - The US Food and Drug Administration's (FDA) Total Diet Study (TDS) has been conducted continuously since the early 1960s to measures levels of various pesticide residues, contaminants, and nutrients in foods and to estimate the dietary exposures to these compounds. Both the TDS food list and the consumption amounts used for estimating exposures are based on results of nationwide food consumption surveys, and they are updated periodically to reflect changes in food consumption patterns. The most recent update was completed in 2003 using the same methodology employed in the previous update (1990). The updated food list includes approximately the same number of foods (285) as the previous list (290). Although most (75%) foods are the same in both versions, the new list reflects trends in consumption of foods containing less fat. The updated diets reflect an increase in total food consumption, with most notable increases in consumption of grains and beverages. A case study comparing cadmium exposures calculated from both the 1990 and 2003 versions of the TDS demonstrated the potential impact of changes in both the food list and consumption amounts on TDS exposure estimates.Journal of Exposure Science and Environmental Epidemiology (2007) 17, 573–582; doi:10.1038/sj.jes.7500554; published online 4 April 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PESTICIDE residues in food
KW - FOOD consumption
KW - CONSUMPTION (Economics)
KW - NUTRITION surveys
KW - PUBLIC health
KW - dietary exposure
KW - monitoring
KW - TDS diets
KW - TDS food list
KW - Total Diet Study (TDS)
N1 - Accession Number: 26547545; Egan, Sara Kathleen 1; Email Address: Katie.Egan@fda.hhs.gov Bolger, Philip Michael 1 Carrington, Clark Dewitt 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA; Source Info: Sep2007, Vol. 17 Issue 6, p573; Subject Term: PESTICIDE residues in food; Subject Term: FOOD consumption; Subject Term: CONSUMPTION (Economics); Subject Term: NUTRITION surveys; Subject Term: PUBLIC health; Author-Supplied Keyword: dietary exposure; Author-Supplied Keyword: monitoring; Author-Supplied Keyword: TDS diets; Author-Supplied Keyword: TDS food list; Author-Supplied Keyword: Total Diet Study (TDS); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1038/sj.jes.7500554
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26547545&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim Halbert, Mary
AU - Archer, Jeffrey C.
T1 - Dioxin and furan contamination of deodorizer distillates and natural vitamin E supplements
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2007/09//
VL - 20
IS - 6
M3 - Article
SP - 506
EP - 514
SN - 08891575
AB - Abstract: Thirty-five samples of vitamin E supplement softgels, obtained from store shelves, were analyzed for 17 dioxin and furan congeners. Of these samples, 14 were identified as natural vitamin E, containing D-α-tocopherol, as well as lesser amounts of β-, α-, and δ-tocopherols, and the remaining 21 were labeled as synthetic vitamin E, containing a mixture of D- and L-α-tocopherol. The supplements were collected during the years of 2002 and 2004. The seven natural vitamin E supplements collected in 2002 were found to contain significant quantities of dioxins and furans, with an average total toxic equivalence (TEQ) of 0.79pg/g, compared to 0.10g/g for the 2004 natural vitamin E supplements. The 21 synthetic vitamin E supplements collected during the same time period showed little or no contamination, with an average TEQ of 0.057pg/g. Eight samples of deodorizer distillate, from which natural vitamin E is derived, were also collected and analyzed. The distillates exhibit an overall congener pattern similar to that found in the natural vitamin E, but at a much higher average TEQ of 3.4pg/g. This suggests the possibility of carryover of contamination to the vitamin E samples from the deodorizer distillate during the extraction process. The natural vitamin E supplements collected in 2004 have much lower levels of contamination, suggesting that improved extraction processes may be in use, effectively reducing contamination. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOPENTENOIDS
KW - FAT-soluble vitamins
KW - TETRACHLORODIBENZODIOXIN
KW - AGENT Orange
KW - Bleaching clay
KW - Deodorizer distillate
KW - Dioxin
KW - Furan
KW - PCDD
KW - PCDF
KW - Tocopherol
KW - Vitamin E
N1 - Accession Number: 25316080; Kim Halbert, Mary; Email Address: mary.halbert@fda.hhs.gov Archer, Jeffrey C. 1; Affiliation: 1: Food and Drug Administration, Arkansas Regional Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Sep2007, Vol. 20 Issue 6, p506; Subject Term: ISOPENTENOIDS; Subject Term: FAT-soluble vitamins; Subject Term: TETRACHLORODIBENZODIOXIN; Subject Term: AGENT Orange; Author-Supplied Keyword: Bleaching clay; Author-Supplied Keyword: Deodorizer distillate; Author-Supplied Keyword: Dioxin; Author-Supplied Keyword: Furan; Author-Supplied Keyword: PCDD; Author-Supplied Keyword: PCDF; Author-Supplied Keyword: Tocopherol; Author-Supplied Keyword: Vitamin E; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jfca.2007.02.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25316080&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Holman, Robert C.
AU - Yorita, Krista L.
AU - Singleton, Rosalyn J.
AU - Cheek, James E.
AU - Paisano, Edna L.
AU - Butler, Jay C.
AU - Anderson, Larry J.
AU - Fry, Alicia M.
T1 - Increasing Rate of Pneumonia Hospitalizations among Older American Indian and Alaska Native Adults.
JO - Journal of Health Disparities Research & Practice
JF - Journal of Health Disparities Research & Practice
Y1 - 2007///Fall2007
VL - 2
IS - 1
M3 - Article
SP - 35
EP - 49
AB - Objective. To examine rates and trends of pneumonia hospitalization among older American Indian and Alaska Native (AI/AN) adults. Methods. Pneumonia hospitalizations for older AI/AN adults =65 years of age living in the Alaska and Southwest Indian Health Service (IHS) regions during 1988 through 2002 from the IHS hospital discharge data were analyzed. Results. The average annual hospitalization rate for first-listed pneumonia for older AI/AN adults in both the Alaska and the Southwest regions has increased (15.3 and 23.0 in 1988-1990 to 25.9 and 28.8 in 2000-2002 per 1,000 population, respectively), with the greatest increase seen among older AI/AN adults in the Alaska region. For both regions, the hospitalization rate increased with increasing age. The proportion of pneumonia hospitalizations with the co-morbid conditions of chronic heart disease, chronic lung disease and diabetes mellitus in the Alaska and the Southwest regions increased from 48.8% and 30.8% in 1988-1990 to 65.4% and 40.7% in 2000-2002, respectively. Conclusions. The rate of pneumonia hospitalizations among older AI/AN adults in the Alaska and the Southwest regions has increased substantially; the 2000-2002 rate was similar to or slightly higher than those reported for the general older US population. This rate increase and the increasing prevalence of chronic co-morbid conditions indicate a need for prevention efforts and health interventions among older AI/AN adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Disparities Research & Practice is the property of Center for Health Disparities & Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATIVE Americans
KW - ADULTS
KW - HOSPITAL care
KW - EPIDEMIOLOGY
KW - PNEUMONIA
KW - LUNG diseases
KW - DIABETES
KW - HEART diseases
KW - UNITED States
KW - adults
KW - American Indians
KW - epidemiology
KW - hospitalization
KW - pneumonia
N1 - Accession Number: 31371480; Holman, Robert C. 1 Yorita, Krista L. 1 Singleton, Rosalyn J. 2 Cheek, James E. 3 Paisano, Edna L. 3 Butler, Jay C. 4 Anderson, Larry J. 1 Fry, Alicia M. 1; Affiliation: 1: Centers for Disease Control and Prevention 2: Alaska Native Tribal Health Consortium and Centers for Disease Control and Prevention 3: Indian Health Service 4: Alaska Division of Public Health; Source Info: Fall2007, Vol. 2 Issue 1, p35; Subject Term: NATIVE Americans; Subject Term: ADULTS; Subject Term: HOSPITAL care; Subject Term: EPIDEMIOLOGY; Subject Term: PNEUMONIA; Subject Term: LUNG diseases; Subject Term: DIABETES; Subject Term: HEART diseases; Subject Term: UNITED States; Author-Supplied Keyword: adults; Author-Supplied Keyword: American Indians; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: pneumonia; Number of Pages: 15p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Asturias, Edwin J.
AU - Dueger, Erica L.
AU - Omer, Saad B.
AU - Melville, Arturo
AU - Nates, Silvia V.
AU - Laassri, Majid
AU - Chumakov, Konstantin
AU - Halsey, Neal A.
T1 - Randomized Trial of Inactivated and Live Polio Vaccine Schedules in Guatemalan Infants.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/09//9/1/2007
VL - 196
IS - 5
M3 - Article
SP - 692
EP - 698
SN - 00221899
AB - Background. The immunogenicity of inactivated poliovirus vaccine (IPV) in developing countries is not well documented. This study compared the immune response to IPV with that to oral poliovirus vaccine (OPV) in Guatemalan infants. Methods. This was an open-label, randomized comparison of IPV only, OPV only, or IPV followed by OPV in Guatemalan public health clinics. Serum samples were tested for neutralizing antibodies, and stool samples were tested for Sabin strain polioviruses. Results. Seropositivity rates 2 months after 2 doses of IPV were 98%-100% for polio types 1, 2, and 3 and were 97.1%, 99.3%, and 92.1% for OPV-only recipients (P<.001 for the response to type 3). One month after the third dose, 100% of IPV-only recipients had protective antibodies against all 3 types, compared with 99%, 100%, and 97% against polio types 1, 2, and 3 respectively, among recipients of OPV only. Infants who received IPV only had higher geometric mean titers than infants who received OPV only. Maternal antibodies lowered the final antibody responses to IPV but did not prevent the development of protective levels of antibody. Of 191 stool samples from infants who received IPV only, 5 (2.6%) were positive for poliovirus vaccine strains. Conclusions. IPV alone and IPV followed by OPV are safe and effective for Guatemalan infants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - POLIOVIRUS
KW - IMMUNE response
KW - IMMUNOLOGY
KW - PUBLIC health research
KW - HEALTH planning
KW - CELLULAR immunity
KW - INFANT diseases
KW - GUATEMALA
N1 - Accession Number: 26240132; Asturias, Edwin J. 1,2 Dueger, Erica L. 1,2 Omer, Saad B. 1 Melville, Arturo 3 Nates, Silvia V. 4 Laassri, Majid 5 Chumakov, Konstantin 5 Halsey, Neal A. 1; Email Address: nhalsey@jhsph.edu; Affiliation: 1: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore 2: Center for Health Studies, University del Valle de Guatemala 3: Department of Pediatrics, Hospital Roosevelt Guatemala, Guatemala City, Guatemala 4: Instituto de Virología "Dr. J. M. Vanella," Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina 5: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland; Source Info: 9/1/2007, Vol. 196 Issue 5, p692; Subject Term: VACCINATION; Subject Term: POLIOVIRUS; Subject Term: IMMUNE response; Subject Term: IMMUNOLOGY; Subject Term: PUBLIC health research; Subject Term: HEALTH planning; Subject Term: CELLULAR immunity; Subject Term: INFANT diseases; Subject Term: GUATEMALA; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/520546
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harper, Martin
AU - Demange, Martine
T1 - Concerning Sampler Wall Deposits in the Chemical Analysis of Airborne Metals.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/09//
VL - 4
IS - 9
M3 - Article
SP - 81
EP - 86
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article focuses on sampler wall deposits used in the analysis of airborne metals. The various samplers used for collecting, measuring, and analyzing collected aerosols are discussed and evaluated. The design and development of closed-face cassette (CFC) sampler and the development of a sampler by the Institute of Occupational Medicine (IOM) in Great Britain are discussed. The wall deposits in both CFC and IOM samplers were collected, analyzed and compared. The examination of the two samplers reveal that filter and wall deposit masses in both CFC and IOM samplers were comparable and thus conform to the ISO standard on size-based collection efficiencies of samplers developed to match the penetration to the lung.
KW - Aerosols (Sprays)
KW - Filters & filtration
KW - Air filters
KW - Air pollution
KW - Air purification equipment industry
KW - Air -- Purification
KW - Atmospheric aerosols
KW - Contamination (Technology)
KW - Air filters -- Design & construction
N1 - Accession Number: 25729803; Harper, Martin 1; Demange, Martine 2; Affiliations: 1: National Institute for Occupational Safety and Health. Morgantown, West Virginia; 2: Institut National de Recherche et de Sécurité, Vandoeuvre, France; Issue Info: Sep2007, Vol. 4 Issue 9, p81; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Filters & filtration; Thesaurus Term: Air filters; Thesaurus Term: Air pollution; Thesaurus Term: Air purification equipment industry; Thesaurus Term: Air -- Purification; Thesaurus Term: Atmospheric aerosols; Thesaurus Term: Contamination (Technology); Subject Term: Air filters -- Design & construction; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 335210 Small Electrical Appliance Manufacturing; NAICS/Industry Codes: 333413 Industrial and Commercial Fan and Blower and Air Purification Equipment Manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1080/15459620701493149
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ziqing Zhuang
AU - Bradtmiller, Bruce
AU - Shaffer, Ronald E.
T1 - New Respirator Fit Test Panels Representing the Current U.S. Civilian Work Force.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/09//
VL - 4
IS - 9
M3 - Article
SP - 647
EP - 659
PB - Taylor & Francis Ltd
SN - 15459624
AB - The fit test panels currently used for respirator research, design, and certification are 25-subject panels developed by Los Alamos National Laboratory (LANL) and are based on data from the 1967 and 1968 anthropometric surveys of U.S. Air Force personnel. Military data do not represent the great diversity in face size and shape seen in civilian populations. In addition, the demographics of the U.S. population have changed over the last 30 years. Thus, it is necessary to assess and refine the LANL fit test panels. This paper presents the development of new respirator fit test panels representative of current U.S. civilian workers based on an anthropometric survey of 3997 respirator users conducted in 2003. One panel was developed using face length and face width (bivariate approach) and weighting subjects to match the age and race distribution of the U.S. population as determined from the 2000 census. Another panel was developed using the first two principal components obtained from a set of 10 facial dimensions (age and race adjusted). These 10 dimensions are associated with respirator fit and leakage and can predict the remaining face dimensions well. Respirators designed to fit these panels are expected to accommodate more than 95% of the current U.S. civilian workers. Both panels are more representative of the U.S. population than the existing LANL panel and may be appropriate for testing both half-masks and full-facepiece respirators. Respirator manufacturers, standards development organizations, and government respirator certification bodies need to select the appropriate fit test panel for their particular needs. The bivariate panel is simpler to use than the principal component analysis (PCA) panel and is most similar to the LANL panel currently used. The inclusion of the eight additional facial measurements allows the PCA panel to provide better criteria for excluding extreme face sizes from being used. Because the boundaries of the two new panels are significantly different from the LANL panel, it may be necessary to develop new respirator sizing systems. A new five-category sizing system is proposed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Artificial respiration
KW - Principal components analysis
KW - Factor analysis
KW - Breathing apparatus
KW - Gas masks
KW - Breathing apparatus -- Safety measures
KW - Industries -- United States
KW - United States
KW - civilian workers
KW - fit test panels
KW - respirator sizing
KW - respirators
KW - Los Alamos National Laboratory
N1 - Accession Number: 25729801; Ziqing Zhuang 1; Email Address: zaz3@cdc.gov; Bradtmiller, Bruce 2; Shaffer, Ronald E. 1; Affiliations: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania; 2: Anthrotech, Yellow Springs, Ohio; Issue Info: Sep2007, Vol. 4 Issue 9, p647; Thesaurus Term: Artificial respiration; Thesaurus Term: Principal components analysis; Thesaurus Term: Factor analysis; Subject Term: Breathing apparatus; Subject Term: Gas masks; Subject Term: Breathing apparatus -- Safety measures; Subject Term: Industries -- United States; Subject: United States; Author-Supplied Keyword: civilian workers; Author-Supplied Keyword: fit test panels; Author-Supplied Keyword: respirator sizing; Author-Supplied Keyword: respirators ; Company/Entity: Los Alamos National Laboratory; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 13p; Illustrations: 2 Diagrams, 8 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/15459620701497538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=25729801&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Murphy, William J.
AU - Tubbs, Randy L.
T1 - Assessment of Noise Exposure for Indoor and Outdoor Firing Ranges.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/09//
VL - 4
IS - 9
M3 - Article
SP - 688
EP - 697
PB - Taylor & Francis Ltd
SN - 15459624
AB - The National Institute for Occupational Safety and Health (NIOSH) received an employee request for a health hazard evaluation of a Special Weapons Assault Team (SWAT) in January 2002. The department was concerned about noise exposures and potential hearing damage from weapons training on their indoor and outdoor firing ranges. NIOSH investigators conducted noise sampling with an acoustic mannequin head and 1/4-inch microphone to characterize the noise exposures that officers might experience during small arms qualification and training when wearing a variety of hearing protectiondevices provided by the department. The peak sound pressure levels for the various weapons ranged from 156 to 170 decibels (dB SPL), which are greater than the recommended allowable140 dB SPL exposure guideline from NIOSH. The earplugs, ear muffs, and customized SWAT team hearing protectors provided between 25 and 35 dB of peak reduction. Double hearing protection (plugs plus muffs) added 15-20 dB of peak reduction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Noise
KW - Hearing protection
KW - Bombing & gunnery ranges
KW - Deafness
KW - Weapons
KW - firing range
KW - hearing loss
KW - hearing protection devices
KW - impulse noise
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 59794590; Murphy, William J. 1; Email Address: wmurphy@cdc.gov; Tubbs, Randy L. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Hearing Loss Prevention Team, Cincinnati, Ohio; 2: National Institute for Occupational Safety and Health, Division of Surveillance Hazard Evaluations and Field Studies, Hazard Evaluations and Technical Assistance Branch, Cincinnati, Ohio; Issue Info: Sep2007, Vol. 4 Issue 9, p688; Thesaurus Term: RESEARCH; Subject Term: Noise; Subject Term: Hearing protection; Subject Term: Bombing & gunnery ranges; Subject Term: Deafness; Subject Term: Weapons; Author-Supplied Keyword: firing range; Author-Supplied Keyword: hearing loss; Author-Supplied Keyword: hearing protection devices; Author-Supplied Keyword: impulse noise ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15459620701537390
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=59794590&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105072897
T1 - Assessment of noise exposure for indoor and outdoor firing ranges.
AU - Murphy WJ
AU - Tubbs RL
Y1 - 2007/09//
N1 - Accession Number: 105072897. Language: English. Entry Date: 20100813. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Note: For CE see Suppl pages D93-4. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Ear Protective Devices -- Standards
KW - Firearms
KW - Noise
KW - Occupational Exposure
KW - Education, Continuing (Credit)
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Human
KW - National Institute for Occupational Safety and Health
KW - United States
SP - 688
EP - 697
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety and Health (NIOSH) received an employee request for a health hazard evaluation of a Special Weapons Assault Team (SWAT) in January 2002. The department was concerned about noise exposures and potential hearing damage from weapons training on their indoor and outdoor firing ranges. NIOSH investigators conducted noise sampling with an acoustic mannequin head and 1/4-inch microphone to characterize the noise exposures that officers might experience during small arms qualification and training when wearing a variety of hearing protection devices provided by the department. The peak sound pressure levels for the various weapons ranged from 156 to 170 decibels (dB SPL), which are greater than the recommended allowable 140 dB SPL exposure guideline from NIOSH. The earplugs, ear muffs, and customized SWAT team hearing protectors provided between 25 and 35 dB of peak reduction. Double hearing protection (plugs plus muffs) added 15-20 dB of peak reduction.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Hearing Loss Prevention Team, 4676 Columbia Parkway, MS C-27, Cincinnati, OH 45226; wmurphy@cdc.gov
U2 - PMID: 17654224.
DO - 10.1080/15459620701537390
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105072897&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109848944
T1 - Sleepless in the hospital: evidence mounts that tired caregivers may compromise quality.
AU - Clancy CM
Y1 - 2007/09//2007 Sep
N1 - Accession Number: 109848944. Language: English. Entry Date: 20080321. Revision Date: 20150923. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 101233393.
KW - Caregivers
KW - Fatigue
KW - Quality of Health Care
KW - Human Error
KW - Interns and Residents
KW - Nurses
KW - Research
KW - Shiftwork
KW - Treatment Errors -- Prevention and Control
SP - 125
EP - 126
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 3
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; carolyn.clancy@ahrq.hhs.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109848944&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109848945
T1 - Simulation in health care: setting realistic expectations.
AU - Henriksen K
AU - Patterson MD
Y1 - 2007/09//2007 Sep
N1 - Accession Number: 109848945. Language: English. Entry Date: 20080321. Revision Date: 20150923. Publication Type: Journal Article; review. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 101233393.
KW - Clinical Competence -- Education
KW - Computer Simulation
KW - Health Personnel -- Education
KW - Patient Safety
KW - Computer Simulation -- Economics
KW - Decision Making, Clinical
KW - Invasive Procedures -- Education
KW - Learning Styles
KW - Outcomes (Health Care)
KW - Physical Performance
KW - Research Question
KW - Schools, Medical
KW - Teamwork -- Education
SP - 127
EP - 134
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 3
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, Department of Health and Human Services, 540 Gaither Road, Rockville, MD 20850; KHenriks@ahrq.hhs.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109848945&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zidan, Ahmed S.
AU - Sammour, Omaima A.
AU - Hammad, Muhammad A.
AU - Megrab, Nagia A.
AU - Habib, Mohamed J.
AU - Khan, Mansoor A.
T1 - Quality by design: Understanding the product variability of a self-nanoemulsified drug delivery system of cyclosporine A.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/09//
VL - 96
IS - 9
M3 - Article
SP - 2409
EP - 2423
SN - 00223549
AB - The objective of this work was to understand the product variability due to size and other characteristics of the SNEDDS by utilizing near infrared (NIR) and chemometric analysis, as well as several other well-known procedures. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region using CyA solutions in sweet orange oil (oily phase), Emulphor EL-620 (surfactant), and Capmul MCM-C8 (cosurfactant). The formulated SNEDDS were characterized by droplet size, turbidity, zeta potential, and Fourier transform infrared (FTIR) analysis. Drug release studies were performed by dissolution in conjunction with turbidimetry. Permeability studies were performed in a Franz diffusion cell assembly. The results indicated an optimum surfactant to cosurfactant ratio of 2:1. Above this ratio, the resultant nanoemulsions had a particle size of 10 nm and turbidity of 10 nephlometric units (NTU). All the prepared systems were positively charged. The FTIR spectra and the DSC thermograms obtained showed no incompatibility between the SNEDDS ingredients. Turbidity time profiles revealed three distinctive regions: lag phase, plateau, and pseudolinear phase. Emulsification rate was obtained from the corrected slope of the pseudolinear phase of the profile. Permeability data indicated that the product variability is more with smaller droplet size. The size of the droplets showed good correlation with NIR spectral data by partial least square (PLS) regression plots. In conclusion, this study demonstrated the ability to understand the impact of nanodroplets size on the SNEDDS variability by different product analyzing tools. © 2007 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 96: 2409–2423, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG delivery systems
KW - CYCLOSPORINE
KW - CHEMOMETRICS
KW - PERMEABILITY
KW - TURBIDITY
KW - TEMPERATURE measuring instruments
KW - cyclosporine
KW - permeability and near infrared
KW - self-nanoemulsification
KW - variability
N1 - Accession Number: 25972837; Zidan, Ahmed S. 1,2,3 Sammour, Omaima A. 2 Hammad, Muhammad A. 2 Megrab, Nagia A. 2 Habib, Mohamed J. 3 Khan, Mansoor A. 1; Email Address: Mansoor.Khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Food and Drug Administration, Silver Spring, Maryland 2: Faculty of Pharmacy, Zagazig University, Zagazig, Sharqiyyah Province, Egypt 3: School of Pharmacy, Howard University, Washington, District of Columbia; Source Info: Sep2007, Vol. 96 Issue 9, p2409; Subject Term: DRUG delivery systems; Subject Term: CYCLOSPORINE; Subject Term: CHEMOMETRICS; Subject Term: PERMEABILITY; Subject Term: TURBIDITY; Subject Term: TEMPERATURE measuring instruments; Author-Supplied Keyword: cyclosporine; Author-Supplied Keyword: permeability and near infrared; Author-Supplied Keyword: self-nanoemulsification; Author-Supplied Keyword: variability; Number of Pages: 15p; Illustrations: 1 Diagram, 2 Charts, 11 Graphs; Document Type: Article
L3 - 10.1002/jps.20824
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=25972837&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Kim, Ki-Suk
AU - Park, Sang-Joon
AU - Na, Hankwang
AU - Park, Hae-Sung
AU - Kim, Eun-Joo
T1 - EFFECT OF HERG CURRENT BY DRUGS IN hERG TRAFFICKING MUTANTS
JO - Journal of Pharmacological & Toxicological Methods
JF - Journal of Pharmacological & Toxicological Methods
Y1 - 2007/09//
VL - 56
IS - 2
M3 - Abstract
SP - e5
EP - e5
SN - 10568719
N1 - Accession Number: 26571239; Kim, Ki-Suk 1; Park, Sang-Joon 1; Na, Hankwang 2; Park, Hae-Sung 1; Kim, Eun-Joo 1; Affiliations: 1: Korea Institute of Toxicology, Daejeon, Korea; 2: Korea Food and Drug Administration, Seoul, Korea; Issue Info: Sep2007, Vol. 56 Issue 2, pe5; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.vascn.2007.02.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26571239&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hsueh, Huey-Miin
AU - Tsai, Chen-An
AU - Chen, James J.
T1 - Incorporating the number of true null hypotheses to improve power in multiple testing: application to gene microarray data.
JO - Journal of Statistical Computation & Simulation
JF - Journal of Statistical Computation & Simulation
Y1 - 2007/09//
VL - 77
IS - 9
M3 - Article
SP - 757
EP - 767
SN - 00949655
AB - Testing for significance with gene expression data from DNA microarray experiments involves simultaneous comparisons of hundreds or thousands of genes. In common exploratory microarray experiments, most genes are not expected to be differentially expressed. The family-wise error (FWE) rate and false discovery rate (FDR) are two common approaches used to account for multiple hypothesis tests to identify differentially expressed genes. When the number of hypotheses is very large and some null hypotheses are expected to be true, the power of an FWE or FDR procedure can be improved if the number of null hypotheses is known. The mean of differences (MD) of ranked p-values has been proposed to estimate the number of true null hypotheses under the independence model. This article proposes to incorporate the MD estimate into an FWE or FDR approach for gene identification. Simulation results show that the procedure appears to control the FWE and FDR well at the FWE=0.05 and FDR=0.05 significant levels; it exceeds the nominal level for FDR=0.01 when the null hypotheses are highly correlated, a correlation of 0.941. The proposed approach is applied to a public colon tumor data set for illustration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Statistical Computation & Simulation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - DNA
KW - HYPOTHESIS
KW - ANALYSIS of covariance
KW - DNA microarrays
KW - Complete null hypothesis
KW - False discovery rate (FDR)
KW - Family-wise error rate (FWE)
KW - Number of true null hypotheses
KW - p-values
N1 - Accession Number: 26447058; Hsueh, Huey-Miin 1 Tsai, Chen-An 2 Chen, James J. 3; Email Address: jchen@nctr.fda.gov; Affiliation: 1: Department of Statistics, National Cheng-Chi University, Taipei, Taiwan 2: Institute of Statistical Science, Academia Sinica, Taipei, Taiwan 3: Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; Source Info: Sep2007, Vol. 77 Issue 9, p757; Subject Term: GENES; Subject Term: DNA; Subject Term: HYPOTHESIS; Subject Term: ANALYSIS of covariance; Subject Term: DNA microarrays; Author-Supplied Keyword: Complete null hypothesis; Author-Supplied Keyword: False discovery rate (FDR); Author-Supplied Keyword: Family-wise error rate (FWE); Author-Supplied Keyword: Number of true null hypotheses; Author-Supplied Keyword: p-values; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10629360600648651
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26447058&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moritsugu, Kenneth P.
T1 - Underage Drinking: A Call to Action
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2007/09//
VL - 107
IS - 9
M3 - Editorial
SP - 1464
EP - 1464
SN - 00028223
N1 - Accession Number: 26433795; Moritsugu, Kenneth P. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Sep2007, Vol. 107 Issue 9, p1464; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2007.06.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26433795&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Subramanian, Sujha
AU - Hoover, Sonja
AU - Gilman, Boyd
AU - Field, Terry S.
AU - Mutter, Ryan
AU - Gurwitz, Jerry H.
T1 - Computerized Physician Order Entry with Clinical Decision Support in Long-Term Care Facilities: Costs and Benefits to Stakeholders.
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
Y1 - 2007/09//
VL - 55
IS - 9
M3 - Article
SP - 1451
EP - 1457
PB - Wiley-Blackwell
SN - 00028614
AB - Nursing homes are the setting of care for growing numbers of our nation's older people, and adverse drug events are an increasingly recognized safety and quality concern in this population. Health information technology, including computerized physician/provider order entry (CPOE) with clinical decision support (CDS), has been proposed as an important systems-based approach for reducing medication errors and preventable drug-related injuries. This article describes the costs and benefits of CPOE with CDS for the various stakeholders involved in long-term care (LTC), including nurses, physicians, the pharmacy, the laboratory, the payer (e.g., the insurer), nursing home residents, and the LTC facility. Critical barriers to adoption of these systems are discussed, primarily from an economic perspective. The analysis suggests that multiple stakeholders will incur the costs related to implementation of CPOE with CDS in the LTC setting, but the costs incurred by each may not be aligned with the benefits, which may present a major barrier to broad adoption. Physicians and LTC facilities are likely to bear a large burden of the costs, whereas residents and payers will enjoy a large portion of the benefits. Consideration of these costs and benefits suggests that financial incentives to physicians and facilities may be necessary to encourage and accelerate widespread use of these systems in the LTC setting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities
KW - ORDER entry
KW - LONG-term care facilities
KW - OLDER people -- Institutional care
KW - HEALTH facilities
KW - GERIATRICS
KW - computer decision support
KW - economics
KW - long-term care
N1 - Accession Number: 26334790; Subramanian, Sujha 1 Hoover, Sonja 1 Gilman, Boyd 1 Field, Terry S. 2 Mutter, Ryan 3 Gurwitz, Jerry H. 2; Email Address: jgurwitz@meyersprimary.org; Affiliation: 1: RTI International, Waltham, Massachusetts; 2: Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic, Foundation, and Fallon Community Health Plan, Worcester, Massachusetts; and 3: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Sep2007, Vol. 55 Issue 9, p1451; Subject Term: NURSING care facilities; Subject Term: ORDER entry; Subject Term: LONG-term care facilities; Subject Term: OLDER people -- Institutional care; Subject Term: HEALTH facilities; Subject Term: GERIATRICS; Author-Supplied Keyword: computer decision support; Author-Supplied Keyword: economics; Author-Supplied Keyword: long-term care; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623311 Continuing Care Retirement Communities; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1532-5415.2007.01304.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26334790&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY -
AU - Harrison, Michael I.1, Michael.Harrison@ahrq.hhs.gov
AU - Koppel, Ross2
AU - Bar-Lev, Shirly3
T1 - Unintended Consequences of Information Technologies in Health Care -- An Interactive Sociotechnical Analysis.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2007/09//Sep/Oct2007
Y1 - 2007/09//Sep/Oct2007
VL - 14
IS - 5
CP - 5
M3 - Article
SP - 542
EP - 549
SN - 10675027
AB - Many unintended and undesired consequences of Healthcare Information Technologies (HIT) flow from interactions between the HIT and the healthcare organization's sociotechnical system--its workflows, culture, social interactions, and technologies. This paper develops and illustrates a conceptual model of these processes that we call Interactive Sociotechnical Analysis (ISTA). ISTA captures common types of interaction with special emphasis on recursive processes, i.e., feedback loops that alter the newly introduced HIT and promote second-level changes in the social system. ISTA draws on prior studies of unintended consequences, along with research in sociotechnical systems, ergonomics, social informatics, technology-in-practice, and social construction of technology. We present five types of sociotechnical interaction and illustrate each with cases from published research. The ISTA model should further research on emergent and recursive processes in HIT implementation and their unintended consequences. Familiarity with the model can also foster practitioners' awareness of unanticipated consequences that only become evident during HIT implementation. [ABSTRACT FROM AUTHOR]
KW - Social informatics
KW - Medical informatics
KW - Medical care
KW - Workflow
KW - Social interaction
KW - Social psychology
N1 - Accession Number: 26964131; Authors: Harrison, Michael I. 1 Email Address: Michael.Harrison@ahrq.hhs.gov; Koppel, Ross 2; Bar-Lev, Shirly 3; Affiliations: 1: Agency for Healthcare Research and Quality, Rockville, MD; 2: University of Pennsylvania, Philadelphia, PA; 3: Ruppin Academic Center, (SB-L) Emek Hefer, Israel; Subject: Medical care; Subject: Workflow; Subject: Social interaction; Subject: Social informatics; Subject: Medical informatics; Subject: Social psychology; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart; Record Type: Article
L3 - 10.1197/jamia.M2384
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=26964131&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 105963173
T1 - Unintended consequences of information technologies in health care--an interactive sociotechnical analysis.
AU - Harrison MI
AU - Koppel R
AU - Bar-Lev S
AU - Harrison, Michael I
AU - Koppel, Ross
AU - Bar-Lev, Shirly
Y1 - 2007/09//Sep/Oct2007
N1 - Accession Number: 105963173. Language: English. Entry Date: 20080208. Revision Date: 20161114. Publication Type: journal article; research. Journal Subset: Blind Peer Reviewed; Computer/Information Science; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Informatics. Grant Information: P01 HS11530/HS/AHRQ HHS/United States. NLM UID: 9430800.
KW - Health Care Delivery -- Administration
KW - Medical Informatics
KW - Health Manpower
KW - Management
KW - Organizational Change
KW - Organizational Culture
SP - 542
EP - 549
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
JA - J AM MED INFORM ASSOC
VL - 14
IS - 5
PB - Oxford University Press / USA
AB - Many unintended and undesired consequences of Healthcare Information Technologies (HIT) flow from interactions between the HIT and the healthcare organization's sociotechnical system-its workflows, culture, social interactions, and technologies. This paper develops and illustrates a conceptual model of these processes that we call Interactive Sociotechnical Analysis (ISTA). ISTA captures common types of interaction with special emphasis on recursive processes, i.e., feedback loops that alter the newly introduced HIT and promote second-level changes in the social system. ISTA draws on prior studies of unintended consequences, along with research in sociotechnical systems, ergonomics, social informatics, technology-in-practice, and social construction of technology. We present five types of sociotechnical interaction and illustrate each with cases from published research. The ISTA model should further research on emergent and recursive processes in HIT implementation and their unintended consequences. Familiarity with the model can also foster practitioners' awareness of unanticipated consequences that only become evident during HIT implementation.
SN - 1067-5027
AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd., Rockville, MD 20850, USA
U2 - PMID: 17600093.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105963173&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wang, Shiow Y.
AU - Lewers, Kim S.
AU - Bowman, Linda
AU - Min Ding
T1 - Antioxidant Activities and Anticancer Cell Proliferation Properties of Wild Strawberries.
JO - Journal of the American Society for Horticultural Science
JF - Journal of the American Society for Horticultural Science
Y1 - 2007/09//
VL - 132
IS - 5
M3 - Article
SP - 647
EP - 658
SN - 00031062
AB - Fruit extracts from 17 to 18 representatives of three strawberry species [Fragaria virginiana Mill., F. chiloensis (L.) Mill., and F. xananassa Duchesne ex Rozier] were tested for the ability to inhibit proliferation of A549 human lung epithelial cancer cells. The fruit extracts also were tested for activities against free radicals, (peroxyl radicals, hydroxyl radicals, singlet oxygen, and superoxide radicals), the activities of antioxidant enzymes [glutathione peroxidase (EC 1.11.1.9), superoxide dismutase (EC 1.15.1.1), guaiacol peroxidase (EC 1.11.1.7), ascorbate peroxidase (EC 1.11.1.11), monodehydroascorbate reductase (EC 1.6.5.4), dehydroascorbate reductase (EC 1.8.5.1), and glutathione reductase (EC 1.6.4.2)], and the activities of nonenzyme antioxidant components, ascorbic acid and glutathione. Correlations between the proliferation of cancer cells and these antioxidant activities were calculated. At the species level, F. virginiana fruit extract inhibited the proliferation of A549 human lung epithelial cancer cells to a significantly greater extent (34% inhibition) than the extracts from fruit of either F. chiloensis (26%) or F. xananassa (25%) (P < 0.0001). Extracts from fruit of F. virginiana also had significantly greater antioxidant activities and higher activities of antioxidant enzymes and nonenzyme components than did extracts from the other two species. Among individual genotypes, there was a high positive correlation between antiproliferation of A549 cancer cells, antioxidant activities against free radicals, activities of antioxidant enzymes, and activities of nonenzyme components. Although all fruit extracts from all the strawberry genotypes inhibited proliferation of A594 cancer cells, fruit extracts from seven F. virginiana genotypes showed significantly greater antiproliferative effects than any of the F. xananassa or F. chiloensis genotypes. These genotypes, CFRA 0982, JP 95-1-1, NC 95-19-1, RH 30, NC 96-48-1, JP 95-9-6, and LH 50-4, may be especially useful in developing cultivars with greater anticancer potential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Horticultural Science is the property of American Society for Horticultural Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIOXIDANTS
KW - STRAWBERRIES
KW - LUNGS -- Cancer
KW - CELL proliferation
KW - SUPEROXIDE dismutase
KW - GLUTATHIONE
KW - VITAMIN C
KW - ENZYMES
KW - THERAPEUTIC use
KW - anthocyanin
KW - Fragaria
KW - free radicals
KW - germplasm
KW - phenolics
N1 - Accession Number: 27872214; Wang, Shiow Y. 1 Lewers, Kim S. 1 Bowman, Linda 2 Min Ding 2; Affiliation: 1: U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Fruit Laboratory, Bldg. 010A, BARC-West, 10300 Baltimore Avenue, Beltsville, MD 20705-2350 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; Source Info: Sep2007, Vol. 132 Issue 5, p647; Subject Term: ANTIOXIDANTS; Subject Term: STRAWBERRIES; Subject Term: LUNGS -- Cancer; Subject Term: CELL proliferation; Subject Term: SUPEROXIDE dismutase; Subject Term: GLUTATHIONE; Subject Term: VITAMIN C; Subject Term: ENZYMES; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: anthocyanin; Author-Supplied Keyword: Fragaria; Author-Supplied Keyword: free radicals; Author-Supplied Keyword: germplasm; Author-Supplied Keyword: phenolics; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Santamaria, Annette B.
AU - Cushing, Colleen A.
AU - Antonini, James M.
AU - Finley, Brent L.
AU - Mowat, Fionna S.
T1 - State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2007/09//
VL - 10
IS - 6
M3 - Article
SP - 417
EP - 465
SN - 10937404
AB - Recent studies report that exposure to manganese (Mn), an essential component of welding electrodes and some steels, results in neurotoxicity and/or Parkinson's disease (PD) in welders. This "state-of-the-science" review presents a critical analysis of the published studies that were conducted on a variety of Mn-exposed occupational cohorts during the last 100 yr, as well as the regulatory history of Mn and welding fumes. Welders often perform a variety of different tasks with varying degrees of duration and ventilation, and hence, to accurately assess Mn exposures that occurred in occupational settings, some specific information on the historical work patterns of welders is desirable. This review includes a discussion of the types of exposures that occur during the welding process - for which limited information relating airborne Mn levels with specific welding activities exists - and the human health studies evaluating neurological effects in welders and other Mn-exposed cohorts, including miners, millers, and battery workers. Findings and implications of studies specifically conducted to evaluate neurobehavioral effects and the prevalence of PD in welders are also discussed. Existing exposure data indicate that, in general, Mn exposures in welders are less than those associated with the reports of clinical neurotoxicity (e.g., "manganism") in miners and smelter workers. It was also found that although manganism was observed in highly exposed workers, the scant exposure-response data available for welders do not support a conclusion that welding is associated with clinical neurotoxicity. The available data might support the development of reasonable "worst-case" exposure estimates for most welding activities, and suggest that exposure simulation studies would significantly refine such estimates. Our review ends with a discussion of the data gaps and areas for future research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANGANESE
KW - ELECTRIC welding -- Electrodes
KW - WELDING rods
KW - STEEL
KW - NEUROTOXICOLOGY
KW - WELDERS (Persons)
KW - PARKINSON'S disease
KW - BRAIN diseases
KW - ENVIRONMENTAL health
N1 - Accession Number: 26287847; Santamaria, Annette B. 1; Email Address: asantamaria@environcorp.com Cushing, Colleen A. 2 Antonini, James M. 3 Finley, Brent L. 4 Mowat, Fionna S. 5; Affiliation: 1: ENVIRON International Corporation, Houston, Texas, USA 2: Exponent, Chicago, Illinois, USA 3: National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA 4: ChemRisk, San Francisco, California, USA 5: Exponent, Menlo Park, California, USA; Source Info: Sep2007, Vol. 10 Issue 6, p417; Subject Term: MANGANESE; Subject Term: ELECTRIC welding -- Electrodes; Subject Term: WELDING rods; Subject Term: STEEL; Subject Term: NEUROTOXICOLOGY; Subject Term: WELDERS (Persons); Subject Term: PARKINSON'S disease; Subject Term: BRAIN diseases; Subject Term: ENVIRONMENTAL health; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 331221 Rolled Steel Shape Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 333990 All other general-purpose machinery manufacturing; NAICS/Industry Codes: 331491 Nonferrous Metal (except Copper and Aluminum) Rolling, Drawing, and Extruding; NAICS/Industry Codes: 331490 Non-ferrous metal (except copper and aluminum) rolling, drawing, extruding and alloying; Number of Pages: 49p; Illustrations: 4 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1080/15287390600975004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26287847&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hye-Yoon Jeong
AU - Jung-Eun Lee
AU - Bo-Kyung Choi
AU - Kyung-Won Seo
AU - Seung-Hee Park
AU - Young-Lim Kim
AU - Kyoung-Min Baek
AU - Kyungwon Lee
AU - Dong-Kwon Rhee
T1 - Molecular Epidemiology of Community-Associated Antimicrobial-Resistant Staphylococcus aureusin Seoul, Korea (2003) Pervasiveness of Multidrug-Resistant SCCmecType II Methicillin-Resistant S. aureus.
JO - Microbial Drug Resistance: Mechanism, Epidemiology, & Disease
JF - Microbial Drug Resistance: Mechanism, Epidemiology, & Disease
Y1 - 2007/09//
VL - 13
IS - 3
M3 - Article
SP - 178
EP - 185
SN - 10766294
AB - There is an extremely high incidence of antimicrobial resistance of the clinical isolates of Staphylococcus aureusin Korea. This study carried out a molecular investigation to determine the prevalence of the community-associated antimicrobial-resistant S. aureusand methicillin-resistant S. aureus(MRSA). The percentage resistance from the nasal swabs of healthy volunteers in 2003 in Seoul is as follows penicillin (91), erythromycin (EM, 14), gentamicin (GM, 9.3), tetracycline (TE, 8.2), cephalothin (4), oxacillin (OX, MRSA; 3.8), clindamycin (CC, 2.6), ciprofloxacin (CIP, 0.8), and sulfamethoxazoletrimethoprim (0.6). The community-associated MRSA (C-MRSA) strains were examined by pulsed-field gel electrophoresis (PFGE) analysis of the SmaI macro-fragments, multilocus sequence typing (MLST), and staphylococcal cassette chromosome mec(SCCmec) typing using the PCR analysis. The Korean C-MRSA isolates were clustered into three distinct groups. One PFGE group containing the C-MRSA strains showed resistance to CC, EM, and GM, a high level (32â96 μgml) of resistance to methicillin, sequence type 5 (ST5), and SCCmectype II, which is the most common hospital associated-MRSA (H-MRSA) isolated in Korea. These results highlight the heterogeneous genetic background of the C-MRSA as well as the pervasiveness of the H-MRSA isolates in this community. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbial Drug Resistance: Mechanism, Epidemiology, & Disease is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Molecular epidemiology
KW - Antibacterial agents
KW - Staphylococcus
KW - Drug resistance in microorganisms
N1 - Accession Number: 27305008; Hye-Yoon Jeong 1; Jung-Eun Lee 1; Bo-Kyung Choi 1; Kyung-Won Seo 1; Seung-Hee Park 1; Young-Lim Kim 1; Kyoung-Min Baek 1; Kyungwon Lee 2; Dong-Kwon Rhee 3; Affiliations: 1: Korea Food and Drug Administration, Seoul, Republic of Korea.; 2: Yonsei University College of Medicine, Seoul, Republic of Korea.; 3: College of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.; Issue Info: Sep2007, Vol. 13 Issue 3, p178; Thesaurus Term: Molecular epidemiology; Thesaurus Term: Antibacterial agents; Subject Term: Staphylococcus; Subject Term: Drug resistance in microorganisms; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27305008&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Lee, Taewon
AU - Delongchamp, Robert R.
AU - Moland, Carrie L.
AU - Branham, William S.
AU - Fuscoe, James C.
AU - Leakey, Julian E.A.
T1 - Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2007/09//
VL - 7
IS - 5
M3 - Article
SP - 322
EP - 329
SN - 15677249
AB - Abstract: This study describes the development of a mitochondria-specific microarray, MitoChip, to measure transcripts of mitochondria-associated genes in various diseases and drug-induced toxicities in the mouse. The array consists of 542 oligonucleotides that represent genes from the mitochondrial and nuclear genomes associated with mitochondrial structure and functions. The expression of mitochondrial genes was measured in the liver of both p53 haplodeficient (+/−) and wild-type (+/+) C3B6F1 female mice exposed to antiretroviral agents, Zidovudine (AZT) and Lamivudine (3TC). Among genes whose expression was significantly altered, a set was selected for real-time PCR analysis to verify their differential gene expression. The real-time PCR data confirmed the observations by microarray analysis suggesting that the MitoChip may be an important tool for examining mitochondrial involvement in diseases and drug-induced toxicities. [Copyright &y& Elsevier]
AB - Copyright of Mitochondrion is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIA
KW - DNA microarrays
KW - OLIGONUCLEOTIDES
KW - GENES
KW - MICE as laboratory animals
KW - Lamivudine (3TC)
KW - Microarray
KW - Mitochondria
KW - Mouse MitoChip
KW - Zidovudine (AZT)
N1 - Accession Number: 26413465; Desai, Varsha G. 1; Email Address: varsha.desai@fda.hhs.gov Lee, Taewon 2 Delongchamp, Robert R. 2 Moland, Carrie L. 1 Branham, William S. 1 Fuscoe, James C. 1 Leakey, Julian E.A. 3; Affiliation: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Division of Biometry and Risk Assessment, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 3: Offices of Scientific Co-ordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Sep2007, Vol. 7 Issue 5, p322; Subject Term: MITOCHONDRIA; Subject Term: DNA microarrays; Subject Term: OLIGONUCLEOTIDES; Subject Term: GENES; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Lamivudine (3TC); Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: Mouse MitoChip; Author-Supplied Keyword: Zidovudine (AZT); NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mito.2007.02.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Freiberger, Friedrich
AU - Claus, Heike
AU - Günzel, Almut
AU - Oltmann-Norden, Imke
AU - Vionnet, Justine
AU - Mülenhoff, Martina
AU - Vogel, Ulrich
AU - Vann, Willie F.
AU - Gerardy-Schahn, Rita
AU - Stummeyer, Katharina
T1 - Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2007/09//
VL - 65
IS - 5
M3 - Article
SP - 1258
EP - 1275
PB - Wiley-Blackwell
SN - 0950382X
AB - The extracellular polysaccharide capsule is an essential virulence factor of Neisseria meningitidis, a leading cause of severe bacterial meningitis and sepsis. Serogroup B strains, the primary disease causing isolates in Europe and America, are encapsulated in α-2,8 polysialic acid (polySia). The capsular polymer is synthesized from activated sialic acid by action of a membrane-associated polysialyltransferase ( NmB-polyST). Here we present a comprehensive characterization of NmB-polyST. Different from earlier studies, we show that membrane association is not essential for enzyme functionality. Recombinant NmB-polyST was expressed, purified and shown to synthesize long polySia chains in a non-processive manner in vitro. Subsequent structure–function analyses of NmB-polyST based on refined sequence alignments allowed the identification of two functional motifs in bacterial sialyltransferases. Both (D/E-D/E-G and HP motif) are highly conserved among different sialyltransferase families with otherwise little or no sequence identity. Their functional importance for enzyme catalysis and CMP-Neu5Ac binding was demonstrated by mutational analysis of NmB-polyST and is emphasized by structural data available for the Pasteurella multocida sialyltransferase PmST1. Together our data are the first description of conserved functional elements in the highly diverse families of bacterial (poly)sialyltransferases and thus provide an advanced basis for understanding structure–function relations and for phylogenetic sorting of these important enzymes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYSACCHARIDE synthesis
KW - PATHOGENIC microorganisms
KW - NEISSERIA meningitidis
KW - MENINGITIS -- Diagnosis
KW - SEPTICEMIA
KW - PHYLOGENY
N1 - Accession Number: 32100051; Freiberger, Friedrich 1 Claus, Heike 2 Günzel, Almut 1 Oltmann-Norden, Imke 1 Vionnet, Justine 3 Mülenhoff, Martina 1 Vogel, Ulrich 2 Vann, Willie F. 3 Gerardy-Schahn, Rita 1 Stummeyer, Katharina 1; Email Address: stummeyer.katharina@mh-hannover.de; Affiliation: 1: Abteilung Zelluläre Chemie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany 2: Institute for Hygiene and Microbiology, University of Wrüzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany 3: Laboratory of Bacterial Toxins, Center for Biologics Evaluation and Research, US FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Sep2007, Vol. 65 Issue 5, p1258; Subject Term: POLYSACCHARIDE synthesis; Subject Term: PATHOGENIC microorganisms; Subject Term: NEISSERIA meningitidis; Subject Term: MENINGITIS -- Diagnosis; Subject Term: SEPTICEMIA; Subject Term: PHYLOGENY; Number of Pages: 18p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2958.2007.05862.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32100051&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brault, Aaron C.
AU - Huang, Claire Y.-H.
AU - Langevin, Stanley A.
AU - Kinney, Richard M.
AU - Bowen, Richard A.
AU - Ramey, Wanichaya N.
AU - Panella, Nicholas A.
AU - Holmes, Edward C.
AU - Powers, Ann M.
AU - Miller, Barry R.
T1 - A single positively selected West Nile viral mutation confers increased virogenesis in American crows.
JO - Nature Genetics
JF - Nature Genetics
Y1 - 2007/09//
VL - 39
IS - 9
M3 - Article
SP - 1162
EP - 1166
PB - Nature Publishing Group
SN - 10614036
AB - West Nile virus (WNV), first recognized in North America in 1999, has been responsible for the largest arboviral epiornitic and epidemic of human encephalitis in recorded history. Despite the well-described epidemiological patterns of WNV in North America, the basis for the emergence of WNV-associated avian pathology, particularly in the American crow (AMCR) sentinel species, and the large scale of the North American epidemic and epiornitic is uncertain. We report here that the introduction of a T249P amino acid substitution in the NS3 helicase (found in North American WNV) in a low-virulence strain was sufficient to generate a phenotype highly virulent to AMCRs. Furthermore, comparative sequence analyses of full-length WNV genomes demonstrated that the same site (NS3-249) was subject to adaptive evolution. These phenotypic and evolutionary results provide compelling evidence for the positive selection of a mutation encoding increased viremia potential and virulence in the AMCR sentinel bird species. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Genetics is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WEST Nile virus
KW - VIRAL genetics
KW - ANIMAL models in research
KW - FLAVIVIRUSES
KW - ENCEPHALITIS
KW - NORTH America
N1 - Accession Number: 26382933; Brault, Aaron C. 1,2; Email Address: acbrault@ucdavis.edu Huang, Claire Y.-H. 2 Langevin, Stanley A. 1 Kinney, Richard M. 2 Bowen, Richard A. 3 Ramey, Wanichaya N. 1 Panella, Nicholas A. 2 Holmes, Edward C. 4,5 Powers, Ann M. 2 Miller, Barry R. 2; Affiliation: 1: Center for Vector-Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA 2: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Fort Collins, Colorado 80522, USA 3: Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA 4: Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA 5: Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA; Source Info: Sep2007, Vol. 39 Issue 9, p1162; Subject Term: WEST Nile virus; Subject Term: VIRAL genetics; Subject Term: ANIMAL models in research; Subject Term: FLAVIVIRUSES; Subject Term: ENCEPHALITIS; Subject Term: NORTH America; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1038/ng2097
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26382933&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
AU - Witter, James
AU - Dionne, Raymond A.
T1 - Stimulating the development of mechanism-based, individualized pain therapies.
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2007/09//
VL - 6
IS - 9
M3 - review
SP - 703
EP - 710
PB - Nature Publishing Group
SN - 14741776
AB - Biomedical science has greatly improved our understanding of pain in recent decades, but few novel molecular entities that address fundamentally new pain mechanisms have entered the clinic, despite dramatically increased pharmaceutical investment. Indeed, virtually all new analgesics approved over the past 25 years are derivatives or reformulations of opioids or aspirin-like drugs, existing drugs given for a new indication or older drugs given by a different route of administration. Here, we discuss factors contributing to this lack of innovation in therapies for pain and advocate public-private partnerships (PPPs) to translate new knowledge into more efficacious and safer treatments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAIN management
KW - PHARMACEUTICAL industry
KW - DRUG development
KW - MEDICAL sciences
KW - MEDICAL research
KW - ANALGESICS
KW - ANIMALS
KW - BIOLOGICAL models
KW - COMBINATION drug therapy
KW - CLINICAL trials
KW - DRUG interactions
KW - PAIN
KW - DRUGS -- Physiological effect
KW - THERAPEUTIC use
N1 - Accession Number: 26396263; Woodcock, Janet 1 Witter, James 1 Dionne, Raymond A. 2; Email Address: dionner@mail.nih.gov; Affiliation: 1: Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland, USA 2: National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA; Source Info: Sep2007, Vol. 6 Issue 9, p703; Subject Term: PAIN management; Subject Term: PHARMACEUTICAL industry; Subject Term: DRUG development; Subject Term: MEDICAL sciences; Subject Term: MEDICAL research; Subject Term: ANALGESICS; Subject Term: ANIMALS; Subject Term: BIOLOGICAL models; Subject Term: COMBINATION drug therapy; Subject Term: CLINICAL trials; Subject Term: DRUG interactions; Subject Term: PAIN; Subject Term: DRUGS -- Physiological effect; Subject Term: THERAPEUTIC use; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Diagram; Document Type: review
L3 - 10.1038/nrd2335
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26396263&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Jianyong
AU - Xu, Zengjun
AU - Fang, Hong
AU - Duhart, Helen M.
AU - Patterson, Tucker A.
AU - Ali, Syed F.
T1 - Gene expression profiling of MPP+-treated MN9D cells: A mechanism of toxicity study
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2007/09//
VL - 28
IS - 5
M3 - Article
SP - 979
EP - 987
SN - 0161813X
AB - Abstract: Parkinson''s disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson''s-like syndromes in humans and animals. MPTP/MPP+ treatment produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been elucidated. In order to gain insights into MPP+-induced neurotoxicity, a gene expression microarray study was performed using a midbrain-derived dopaminergic neuronal cell line, MN9D. Utilizing a two-color reference design, Agilent mouse oligonucleotide microarrays were used to examine relative gene expression changes in MN9D cells treated with 40μM MPP+ compared with controls. Bioinformatics tools were used for data evaluation. Briefly, raw data were imported into the NCTR ArrayTrack database, normalized using a Lowess method and data quality was assessed. The Student''s t-test was used to determine significant changes in gene expression (set as p <0.05, fold change >1.5). Gene Ontology for Function Analysis (GOFFA) and Ingenuity Pathway Analysis were employed to analyze the functions and roles of significant genes in biological processes. Of the 51 significant genes identified, 44 were present in the GOFFA or Ingenuity database. These data indicate that multiple pathways are involved in the underlying mechanisms of MPP+-induced neurotoxicity, including apoptosis, oxidative stress, iron binding, cellular metabolism, and signal transduction. These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - NEUROTOXICOLOGY
KW - PARKINSON'S disease
KW - NEUROTOXIC agents
KW - DNA microarrays
KW - DOPAMINERGIC neurons
KW - Gene expression
KW - Microarray
KW - MN9D cells
KW - MPP+
KW - Neurotoxicity
KW - Parkinson's disease
N1 - Accession Number: 26994078; Wang, Jianyong 1 Xu, Zengjun 1 Fang, Hong 2 Duhart, Helen M. 1 Patterson, Tucker A. 1 Ali, Syed F. 1; Email Address: syed.ali@fda.hhs.gov; Affiliation: 1: Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of Bioinformatics, Z-Tech Corporation, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Sep2007, Vol. 28 Issue 5, p979; Subject Term: GENE expression; Subject Term: NEUROTOXICOLOGY; Subject Term: PARKINSON'S disease; Subject Term: NEUROTOXIC agents; Subject Term: DNA microarrays; Subject Term: DOPAMINERGIC neurons; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: MN9D cells; Author-Supplied Keyword: MPP+; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Parkinson's disease; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.neuro.2007.02.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garey, Joan
AU - Paule, Merle G.
T1 - Effects of chronic low-dose acrylamide exposure on progressive ratio performance in adolescent rats
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2007/09//
VL - 28
IS - 5
M3 - Article
SP - 998
EP - 1002
SN - 0161813X
AB - Abstract: Acrylamide (ACR) is a neurotoxicant known to produce peripheral neuropathy in rats and humans, but little is known of its potential for producing cognitive or motivational alterations. Chronic exposure to low doses of ACR as a food contaminant is known to occur widely in humans. This research evaluated the effects of daily ACR exposure on food-motivated behavior, with exposures beginning prenatally on gestation day 6 and continuing through approximately postnatal day (PND) 85. Plug-positive Fischer 344 dams (9–10 per dose) were gavaged daily with 0, 0.1, 0.3, 1.0 or 5.0mg/kg/day ACR. On PNDs 1–22, pups were gavaged with the same dose their dam had received. On PND 22, pups were weaned and pair-housed with a same-sex littermate and ACR exposure continued at 0, 1, 3, 10 and 50ppm via drinking water. One male and one female pup per litter were tested in an operant chamber under a progressive ratio (PR) schedule of food reinforcement from approximately 6 to 12 weeks of age. Results over 6 weeks of testing indicated a significant treatment effect of ACR on number of reinforcers earned, with Tukey HSD post hoc tests revealing significantly fewer reinforcers earned in the 5.0mg/kg/day dose group than in controls. A significant effect of ACR on response rate was also observed, with the Tukey HSD post hoc tests revealing a significantly lower response rate in the 5.0mg/kg/day group than in controls. No effects of ACR were observed on post-reinforcement pause. These data suggest that daily ACR exposure at 5.0mg/kg/day can produce measurable decrements on aspects of food-motivated behavior. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLAMIDE
KW - NEUROTOXIC agents
KW - NEUROPATHY
KW - RATS as laboratory animals
KW - MOTIVATION (Psychology)
KW - FOOD
KW - Acrylamide
KW - Behavior
KW - Development
KW - Motivation
KW - Neurotoxicity
KW - Progressive ratio
N1 - Accession Number: 26994080; Garey, Joan; Email Address: joan.garey@fda.hhs.gov Paule, Merle G. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA; Source Info: Sep2007, Vol. 28 Issue 5, p998; Subject Term: ACRYLAMIDE; Subject Term: NEUROTOXIC agents; Subject Term: NEUROPATHY; Subject Term: RATS as laboratory animals; Subject Term: MOTIVATION (Psychology); Subject Term: FOOD; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: Behavior; Author-Supplied Keyword: Development; Author-Supplied Keyword: Motivation; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Progressive ratio; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.neuro.2007.07.004
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Freas, S.L.
AU - Chelonis, J.J.
AU - Forzano, L.B.
AU - Paule, M.G.
T1 - Effects of reinforcer type on performance of psychological tasks
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2007/09//
VL - 29
IS - 5
M3 - Abstract
SP - 588
EP - 589
SN - 08920362
N1 - Accession Number: 27153472; Freas, S.L. 1 Chelonis, J.J. 1 Forzano, L.B. 1 Paule, M.G. 2; Affiliation: 1: State University of New York College of Brockport, USA 2: National Center for Toxicological Research, USA; Source Info: Sep2007, Vol. 29 Issue 5, p588; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.ntt.2007.08.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105929045
T1 - A systematic review of tobacco smoking among nursing students.
AU - Smith DR
Y1 - 2007/09//2007 Sep
N1 - Accession Number: 105929045. Language: English. Entry Date: 20080118. Revision Date: 20150820. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Europe; Nursing; Peer Reviewed; UK & Ireland. Special Interest: Evidence-Based Practice; Nursing Education. NLM UID: 101090848.
KW - Smoking -- Epidemiology
KW - Students, Nursing
KW - Cross Sectional Studies
KW - Literature Searching
KW - Medline
KW - Prospective Studies
KW - Smoking Cessation
KW - Systematic Review
KW - Human
SP - 293
EP - 302
JO - Nurse Education in Practice
JF - Nurse Education in Practice
JA - NURSE EDUC PRACT
VL - 7
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - This study was conducted to systematically and critically evaluate the large number of academic publications which have investigated tobacco smoking among nursing students in recent years. It was performed as a state-of-the-art examination of all modern literature published in peer-reviewed, English-language journals since 1990. Although smoking appears to be fairly common among nursing students, its prevalence and distribution varies widely depending on the country of study and time period during which the research was undertaken. Although there is some evidence to suggest that smoking rates increase by year of study in the nursing course, not all research has shown a clear association in this regard. Similarly, the value of anti-smoking interventions for nursing students appears to be limited, based on currently available information. Given these conflicting issues, further research which helps to ascertain why student nurses do not wish to give up their habit is clearly needed both locally and internationally. The development of an international smoking questionnaire may also be useful to help standardize future research on tobacco usage among this vulnerable demographic.
SN - 1471-5953
AD - International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; smith@h.jniosh.go.jp
U2 - PMID: 17689456.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jianjun Zhang
AU - Dhakal, Ishwori
AU - Stone, Angie
AU - Baitang Ning
AU - Greene, Graham
AU - Lang, Nicholas P.
AU - Kadlubar, Fred F.
T1 - Plasma Carotenoids and Prostate Cancer: A Population-Based Case-Control Study in Arkansas.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2007/09//
VL - 59
IS - 1
M3 - Article
SP - 46
EP - 53
PB - Taylor & Francis Ltd
SN - 01635581
AB - Carotenoids possess antioxidant properties and thus may protect against prostate cancer. Epidemiological studies of dietary carotenoids and this malignancy were inconsistent, partially due to dietary assessment error. In this study, we aimed to investigate the relation between plasma concentrations of carotenoids and the risk of prostate cancer in a population-based case-control study in Arkansas. Cases (n = 193) were men with prostate cancer diagnosed in 3 major hospitals, and controls (n = 197) were matched to cases by age, race, and county of residence. After adjustment for confounders, plasma levels of lycopene, lutein/zeaxanthin, and Beta -cryptoxanthin were inversely associated with prostate cancer risk. Subjects in the highest quartile of plasma lycopene (513.7 μ g/l) had a 55% lower risk of prostate cancer than those in the lowest quartile (140.5 μ g/l; P trend = 0.042). No apparent association was observed for plasma Alpha -carotene and Beta -carotene. Further adjustment for the other 4 carotenoids did not materially alter the risk estimates for plasma lycopene, lutein/zeaxanthin, and Beta -cryptoxanthin but appeared to result in an elevated risk with high levels of plasma Alpha -carotene and Beta -carotene. The results of all analyses did not vary substantially by age, race, and smoking status. This study added to the emerging evidence that high circulating levels of lycopene, lutein/zeaxanthin, and Beta-cryptoxanthin are associated with a low risk of prostate cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAROTENOIDS
KW - PROSTATE cancer
KW - LYCOPENE
KW - CANCER -- Nutritional aspects
KW - EPIDEMIOLOGY
KW - ARKANSAS
N1 - Accession Number: 26989650; Jianjun Zhang 1,2 Dhakal, Ishwori 1 Stone, Angie 3,4 Baitang Ning 4 Greene, Graham 2,5 Lang, Nicholas P. 2,3,5 Kadlubar, Fred F. 1,5; Affiliation: 1: Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 2: Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 3: Central Arkansas Veterans Healthcare System, Little Rock, AR 4: Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 5: Department of Surgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR; Source Info: 2007, Vol. 59 Issue 1, p46; Subject Term: CAROTENOIDS; Subject Term: PROSTATE cancer; Subject Term: LYCOPENE; Subject Term: CANCER -- Nutritional aspects; Subject Term: EPIDEMIOLOGY; Subject Term: ARKANSAS; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/01635580701385900
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hein, Misty J.
AU - Stayner, Leslie T.
AU - Lehman, Everett
AU - Dement, John M.
T1 - Follow-up study of chrysotile textile workers: cohort mortality and exposure-response.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2007/09//
VL - 64
IS - 9
M3 - Article
SP - 616
EP - 625
SN - 13510711
AB - Objectives: This report provides an update of the mortality experience of a cohort of South Carolina asbestos textile workers. Methods: A cohort of 3072 workers exposed to chrysotile in a South Carolina asbestos textile plant (1916-77) was followed up for mortality through 2001. Standardised mortality ratios (SMRs) were computed using US and South Carolina mortality rates. A job exposure matrix provided calendar time dependent estimates of chrysotile exposure concentrations. Poisson regression models were fitted for lung cancer and asbestosis. Covoriates considered included sex, race, age, calendar time, birth cohort and time since first exposure. Cumulative exposure lags of 5 and 10 years were considered by disregarding exposure in the most recent 5 and 10 years, respectively. Results: A majority of the cohort was deceased (64%) and 702 of the 1961 deaths occurred since the previous update. Mortality was elevated based on US referent rates for a priori causes of interest including all causes combined (SMR 1.33, 95% CI 1.28 to 1.39); all cancers (SMR 1.27, 95% CI 1.16 to 1.39); oesophageal cancer (SMR 1.87, 95% CI 1.09 to 2.99); lung cancer (SMR 1.95, 95% CI 1.68 to 2.24); ischaemic heart disease (SMR 1.20, 95% CI 1.10 to 1.32); and pneumoconiosis and other respiratory diseases (SMR 4.81, 95% CI 3.84 to 5.94). Mortality remained elevated for these causes when South Carolina referent rates were used. Three cases of mesothelioma were observed among cohort members. Exposure-response modelling for lung cancer, using a linear relative risk model, produced a slope coefficient of 0.0198 (fibre-years/mI) (standard error 0.00496), when cumulative exposure was lagged 10 years. Poisson regression modelling confirmed significant positive relations between estimated chrysotile exposure and lung cancer and asbestosis mortality observed in previous updates of this cohort. Conclusions: This study confirms the findings from previous investigations of excess mortality from lung cancer and asbestosis and a strong exposure-response relation between estimated exposure to chrysotile and mortality from lung cancer and asbestosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Public health
KW - Asbestos industry
KW - Mortality
KW - Heart diseases -- Mortality
KW - Respiratory diseases
N1 - Accession Number: 26581597; Hein, Misty J. 1; Email Address: MHein@cdc.gov; Stayner, Leslie T. 2,3; Lehman, Everett 1; Dement, John M. 4; Affiliations: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois, USA; 3: Risk Evaluation Branch, Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 4: Department of Community and Family Medicine, Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina, USA; Issue Info: Sep2007, Vol. 64 Issue 9, p616; Thesaurus Term: Industrial hygiene; Thesaurus Term: Public health; Subject Term: Asbestos industry; Subject Term: Mortality; Subject Term: Heart diseases -- Mortality; Subject Term: Respiratory diseases; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1136/oem.2006.031005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106011045
T1 - Follow-up study of chrysotile textile workers: cohort mortality and exposure-response.
AU - Hein MJ
AU - Stayner LT
AU - Lehman E
AU - Dement JM
Y1 - 2007/09//
N1 - Accession Number: 106011045. Language: English. Entry Date: 20080229. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Asbestos
KW - Lung Neoplasms -- Mortality
KW - Occupational Diseases -- Mortality
KW - Occupational Exposure -- Adverse Effects
KW - Textile Industry
KW - Adult
KW - Aged
KW - Female
KW - Lung Neoplasms -- Etiology
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Etiology
SP - 616
EP - 625
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 64
IS - 9
PB - BMJ Publishing Group
AB - OBJECTIVES: This report provides an update of the mortality experience of a cohort of South Carolina asbestos textile workers. METHODS: A cohort of 3072 workers exposed to chrysotile in a South Carolina asbestos textile plant (1916-77) was followed up for mortality through 2001. Standardised mortality ratios (SMRs) were computed using US and South Carolina mortality rates. A job exposure matrix provided calendar time dependent estimates of chrysotile exposure concentrations. Poisson regression models were fitted for lung cancer and asbestosis. Covariates considered included sex, race, age, calendar time, birth cohort and time since first exposure. Cumulative exposure lags of 5 and 10 years were considered by disregarding exposure in the most recent 5 and 10 years, respectively. RESULTS: A majority of the cohort was deceased (64%) and 702 of the 1961 deaths occurred since the previous update. Mortality was elevated based on US referent rates for a priori causes of interest including all causes combined (SMR 1.33, 95% CI 1.28 to 1.39); all cancers (SMR 1.27, 95% CI 1.16 to 1.39); oesophageal cancer (SMR 1.87, 95% CI 1.09 to 2.99); lung cancer (SMR 1.95, 95% CI 1.68 to 2.24); ischaemic heart disease (SMR 1.20, 95% CI 1.10 to 1.32); and pneumoconiosis and other respiratory diseases (SMR 4.81, 95% CI 3.84 to 5.94). Mortality remained elevated for these causes when South Carolina referent rates were used. Three cases of mesothelioma were observed among cohort members. Exposure-response modelling for lung cancer, using a linear relative risk model, produced a slope coefficient of 0.0198 (fibre-years/ml) (standard error 0.00496), when cumulative exposure was lagged 10 years. Poisson regression modelling confirmed significant positive relations between estimated chrysotile exposure and lung cancer and asbestosis mortality observed in previous updates of this cohort. CONCLUSIONS: This study confirms the findings from previous investigations of excess mortality from lung cancer and asbestosis and a strong exposure-response relation between estimated exposure to chrysotile and mortality from lung cancer and asbestosis.
SN - 1351-0711
AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. MHein@cdc.gov
U2 - PMID: 17449563.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106011045&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jeon, Hyeong-Kyu
AU - Kim, Kyu-Heon
AU - Eom, Keeseon S.
T1 - Complete sequence of the mitochondrial genome of Taenia saginata: Comparison with T. solium and T. asiatica
JO - Parasitology International
JF - Parasitology International
Y1 - 2007/09//
VL - 56
IS - 3
M3 - Article
SP - 243
EP - 246
SN - 13835769
AB - Abstract: The complete sequence of the Taenia saginata mitochondrial genome was determined, and its organization and structure were compared to other human-tropic Taenia tapeworms for which complete mitochondrial sequence data were available. The mitochondrial genome was 13,670 bp long, contained 12 protein-coding genes, two ribosomal RNAs (rRNAs, a small and a large subunit), and 22 transfer RNAs (tRNAs). It did not encode the atp8 gene. Overlapping regions were found between nad4L and nad4, nad1 and trnN, and cox1 and trnT. The ATG initiation codon was used for 10 protein-coding genes, and the GTG initiation codon was used for the remaining 2 genes (nad4 and atp6). The size of the protein-coding genes of the three human Taenia tapeworms did not vary, except for Taenia solium nad1 (891 aa) and nad4 (1212 aa) and Taenia asiatica cox2 (576 aa). The tRNA genes were 57–75 bp long, and the predicted secondary structures of 18 of these genes had typical clover-leaf shapes with paired dihydrouridine (DHU) arms. The genes in all human Taenia tapeworms for the two mitochondrial rRNA subunits rrnL and rrnS are separated by trnC. The putative T. saginata rrnL and rrnS are 972 and 732 bp long, respectively. The non-coding regions of the mt genome of T. saginata consisted of 2 regions: a short non-coding region (SNR, 66 nucleotides) and a long non-coding region (LNR, 159 nucleotides). The overall sequence difference in the full mitochondrial genome between T. saginata and T. asiatica was 4.6%, while T. solium differed by 11%. In conclusion, the complete sequence of the T. saginata mitochondrial genome will serve as a resource for comparative mitochondrial genomics and systematic studies of the parasitic cestodes. [Copyright &y& Elsevier]
AB - Copyright of Parasitology International is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIAL DNA
KW - MITOCHONDRIAL pathology
KW - GENOMICS
KW - PARASITOLOGY
KW - Cestoda
KW - Human Taenia tapeworms
KW - Mitochondrial genome
KW - Parasite
KW - Taenia asiatica
KW - Taenia saginata
KW - Taenia solium
N1 - Accession Number: 25492295; Jeon, Hyeong-Kyu 1 Kim, Kyu-Heon 2 Eom, Keeseon S. 1; Email Address: kseom@chungbuk.ac.kr; Affiliation: 1: Department of Parasitology and Medical Research Institute, Chungbuk National University College of Medicine, Gaeshin-Dong, Chongju, Chungbuk 361-763, South Korea 2: Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Sep2007, Vol. 56 Issue 3, p243; Subject Term: MITOCHONDRIAL DNA; Subject Term: MITOCHONDRIAL pathology; Subject Term: GENOMICS; Subject Term: PARASITOLOGY; Author-Supplied Keyword: Cestoda; Author-Supplied Keyword: Human Taenia tapeworms; Author-Supplied Keyword: Mitochondrial genome; Author-Supplied Keyword: Parasite; Author-Supplied Keyword: Taenia asiatica; Author-Supplied Keyword: Taenia saginata; Author-Supplied Keyword: Taenia solium; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.parint.2007.04.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Carlin, Brian
AU - Carter, Dale
AU - Griffiths, Moira
AU - Lamer, Gregory
AU - Moore, Kevin
AU - Rothman, Barry
AU - Schoneker, David
AU - Sheehan, Catherine
AU - Uppoor, Rajendra
AU - Walsh, Phyllis
AU - Wiens, Robert
T1 - Pharmaceutical Excipient Testing and Control Strategies.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2007/09//
VL - 31
IS - 9
M3 - Article
SP - 84
EP - 104
PB - Advanstar Communications Inc.
SN - 15432521
AB - This article presents collaborative positions among excipient manufacturers, drug product manufacturers, and members of the US Pharmacopeia on key issues pertaining to the control of pharmaceutical excipients stemming from a recent Pharmaceutical Quality Research Institute workshop. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Technology is the property of Advanstar Communications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - RESEARCH institutes
KW - EXCIPIENTS
KW - DRUGS
KW - COLLECTIVE action
N1 - Accession Number: 26502368; Carlin, Brian 1,2; Carter, Dale 1,3; Griffiths, Moira 1,4; Lamer, Gregory 1,5; Moore, Kevin 1,6; Rothman, Barry 1,7; Schoneker, David 1,8,9; Sheehan, Catherine 1,10; Uppoor, Rajendra 1,11; Walsh, Phyllis 1,12; Email Address: phyllis.walsh@spcorp.com; Wiens, Robert 1,13; Email Address: wiensjobert_e@liuy.com; Affiliations: 1: Pharmaceutical Quality Research Institute's Excipient Working Group; 2: Global Manager of Pharmaceutical Research and Development, FMC-Biopolymer, Princeton, NJ; 3: Manager of Product Quality and Management Systems, Office of Compliance and Ethics, Archer Daniels Midland Company, Decatur, IL; 4: Director of Quality Operations, Pfizer, Groton, CT; 5: Statistics Manager, Pfizer Scientific and Laboratory Services, Kalamazoo, MI; 6: Scientist, Excipients, United States Pharmacopeia, Rockville, MD; 7: Senior Compliance Officer, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD; 8: Chair, International Pharmaceutical Excipients Council of the Americas, (IPEC- Americas); 9: Director of Global Regulatory Affairs, Colorcon, West Point, PA; 10: Director, Excipients and Food Chemical Codex, United States Pharmacopela; 11: Pharmacist, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD; 12: Senior Compendial Manager, Schenng-Plough Corporation, Kenilworth, NJ; 13: Senior Quality Representative, Eli Lilly and Company, Indianapolis, IN; Issue Info: Sep2007, Vol. 31 Issue 9, p84; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: RESEARCH institutes; Subject Term: EXCIPIENTS; Subject Term: DRUGS; Subject Term: COLLECTIVE action; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 106188387
T1 - Demand management and case management: a conservation strategy.
AU - Bryant CD
Y1 - 2007/09//2007 Sep-Oct
N1 - Accession Number: 106188387. Language: English. Entry Date: 20071109. Revision Date: 20150819. Publication Type: Journal Article; CEU; exam questions. Note: For CE see pages 281-2. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Case Management. NLM UID: 101291585.
KW - Case Management
KW - Case Management -- History
KW - Cost Control
KW - Education, Continuing (Credit)
KW - Managed Care Programs
KW - Managed Competition
KW - Nursing Role
KW - Quality of Health Care
SP - 272
EP - 280
JO - Professional Case Management
JF - Professional Case Management
JA - PROF CASE MANAGE
VL - 12
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE/OBJECTIVES: This article reviews the history and development of managed competition, and explores the possibilities of a new demand management strategy in the context of nurse case management to offer less costly, higher quality care for a greater number of patients. PRIMARY PRACTICE SETTING(S): The article examines the history and principles of healthcare demand management, its implementation in the hospital and clinical practices of nurse case managers, and its impacts in reducing costs while maintaining care levels. FINDINGS AND CONCLUSIONS: The article develops and analyzes the conflicts and common ground between demand management and case management. First, demand-side strategies can be effective in reducing costs while maintaining quality of nursing care; second, nurse case managers should employ patient education, self-care, and staffing solutions to manage demand. IMPLICATIONS: Nurse case managers must apply demand management principles carefully. Their goal is not to restrict care, but to maintain the highest levels of care possible within the limits of their practice's resources and staffing. Two critical themes emerge: (1) demand management is a potential alternative to market-driven managed competition and (2) nursing case management can affect an effective form of demand management. However, the long-term implications of these nursing case management strategies on healthcare staffing need further exploration.
SN - 1932-8087
AD - Commissioned Corps Nurse Officer in the United States Public Health Service. akb0605@comcast.net.
U2 - PMID: 17885633.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105830779
T1 - Area under the curve and other summary indicators of repeated waking cortisol measurements.
AU - Fekedulegn DB
AU - Andrew ME
AU - Burchfiel CM
AU - Violanti JM
AU - Hartley TA
AU - Charles LE
AU - Miller DB
Y1 - 2007/09//2007 Sep
N1 - Accession Number: 105830779. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 0376505.
KW - Hydrocortisone -- Analysis
KW - Saliva
KW - Factor Analysis
KW - Hydrocortisone -- Pharmacokinetics
KW - Pharmacokinetics
KW - Reference Values
KW - Reproducibility of Results
KW - Wakefulness
KW - Human
SP - 651
EP - 659
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
JA - PSYCHOSOM MED
VL - 69
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: To derive the area under the curve and related summary measures of stress from saliva samples collected over time and to provide insight into the interpretation of the derived parameters. In research designed to assess the health consequences of stress these samples are often used as a physiologic indicator of the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis. To make these repeated measurements of salivary cortisol more useful in defining the relationships between stress and health there is a need to derive two forms of area under the curve that summarize the measurements: area under the curve with respect to ground (AUC(G)) and area under the curve with respect to increase (AUC(I)). The latter parameters, AUC(I), however, is seldom used by research scientists. METHODS: In this study, interpretation and generic definition of the area under the curve was provided through graphical analyses and examination of its association with other summary measures using data from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Pilot Study. In generic form, AUC(I) is derived as the area under the curve above the baseline value minus the area above the curve below the baseline value. RESULTS: The sign and magnitude of AUC(I) are related to the profile and the rate of change of the measurements over time. The parameter showed significant associations with other summary indicators that measure pattern or rate of change of the measurements over time. CONCLUSION: Principal components analyses revealed that summary parameters derived from repeated cortisol measurements can be grouped into two meaningful general categories: measures of the magnitude of response and measures of the pattern of response over time.
SN - 0033-3174
AD - Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD/BEB, MS 4050, 1095 Willowdale Rd., Morgantown, WV 26505, USA. djf7@cdc.gov
U2 - PMID: 17766693.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cummings, Kristin J.
T1 - TUBERCULOSIS CONTROL: CHALLENGES OF AN ANCIENT AND ONGOING EPIDEMIC.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2007/09//Sep/Oct2007
VL - 122
IS - 5
M3 - Article
SP - 683
EP - 692
SN - 00333549
AB - The article focuses on the prevention of tuberculosis (TB). It discusses the benefits of the directly observed therapy (DOT) to patients. It states that several approaches have been employed in developing a better TB vaccine. It claims that the use of MVA85A vaccine as a booster for Bacille Calmette-Guerin (BCG) may prove to be the best strategy in the prevention of the said disease.
KW - TUBERCULOSIS -- Prevention
KW - TUBERCULOSIS patients
KW - TUBERCULOSIS -- Vaccination
KW - BCG vaccination
KW - COMMUNICABLE diseases
N1 - Accession Number: 26202097; Cummings, Kristin J. 1; Email Address: cvx5@cdc.gov; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS 2800, Morgantown, WV 26505; Source Info: Sep/Oct2007, Vol. 122 Issue 5, p683; Subject Term: TUBERCULOSIS -- Prevention; Subject Term: TUBERCULOSIS patients; Subject Term: TUBERCULOSIS -- Vaccination; Subject Term: BCG vaccination; Subject Term: COMMUNICABLE diseases; Number of Pages: 10p; Illustrations: 3 Graphs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105982657
T1 - Public health chronicles. Tuberculosis control: challenges of an ancient and ongoing epidemic.
AU - Cummings KJ
Y1 - 2007/09//Sep/Oct2007
N1 - Accession Number: 105982657. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Public Health
KW - Tuberculosis -- Prevention and Control
KW - Antibiotics, Antitubercular -- Therapeutic Use
KW - Cooperative Behavior
KW - Developing Countries
KW - History
KW - Preventive Health Care -- History
KW - Tuberculosis -- Diagnosis
KW - Tuberculosis -- Drug Therapy
KW - Tuberculosis -- Epidemiology
KW - United States
SP - 683
EP - 692
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 122
IS - 5
PB - Sage Publications Inc.
SN - 0033-3549
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS 2800, Morgantown, WV 26505
U2 - PMID: 17877317.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ilev, Ilko
AU - Waynant, Ronald
AU - Gannot, Israel
AU - Gandjbakhche, Amir
T1 - Simple fiber-optic confocal microscopy with nanoscale depth resolution beyond the diffraction barrier.
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
Y1 - 2007/09//
VL - 78
IS - 9
M3 - Article
SP - 093703
PB - American Institute of Physics
SN - 00346748
AB - A novel fiber-optic confocal approach for ultrahigh depth-resolution (<=2 nm) microscopy beyond the diffraction barrier in the subwavelength nanometric range below 200 nm is presented. The key idea is based on a simple fiber-optic confocal microscope approach that is compatible with a differential confocal microscope technique. To improve the dynamic range of the resolving laser power and to achieve a high resolution in the nanometric range, we have designed a simple apertureless reflection confocal microscope with a highly sensitive single-mode-fiber confocal output. The fiber-optic design is an effective alternative to conventional pinhole-based confocal systems and offers a number of advantages in terms of spatial resolution, flexibility, miniaturization, and scanning potential. Furthermore, the design is compatible with the differential confocal pinhole microscope based on the use of the sharp diffraction-free slope of the axial confocal response curve rather than the area around the maximum of that curve. Combining the advantages of ultrahigh-resolution fiber-optic confocal microscopy, we can work beyond the diffraction barrier in the subwavelength (below 200 nm) nanometric range exploiting confocal nanobioimaging of single cell and intracellular analytes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Review of Scientific Instruments is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBER optics
KW - NANOSCIENCE
KW - CONFOCAL microscopy
KW - OPTICAL diffraction
KW - WAVELENGTHS
N1 - Accession Number: 27002855; Ilev, Ilko 1 Waynant, Ronald 1 Gannot, Israel 2 Gandjbakhche, Amir 3; Affiliation: 1: Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Silver Spring, Maryland 20993–0002 2: Program of Biomedical Engineering, Department of Electrical and Computer Engineering, School of Engineering and Applied Sciences, George Washington University, Washington, D.C. 20052 3: Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Building 9, Bethesda, Maryland 20892; Source Info: Sep2007, Vol. 78 Issue 9, p093703; Subject Term: FIBER optics; Subject Term: NANOSCIENCE; Subject Term: CONFOCAL microscopy; Subject Term: OPTICAL diffraction; Subject Term: WAVELENGTHS; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1063/1.2777173
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yona Amitai
AU - Gary Winston
AU - Joseph Sack
AU - Janice Wasser
AU - Matthew Lewis
AU - Benjamin C. Blount
AU - Liza Valentin-Blasini
AU - Nirah Fisher
AU - Avi Israeli
AU - Alex Leventhal
T1 - Gestational Exposure to High Perchlorate Concentrations in Drinking Water and Neonatal Thyroxine Levels.
JO - Thyroid
JF - Thyroid
Y1 - 2007/09//
VL - 17
IS - 9
M3 - Article
SP - 843
EP - 850
SN - 10507256
AB - Objective: To assess the effect of gestational perchlorate exposure through drinking water on neonatal thyroxine (T4). Design: T4values were compared among newborns in Ramat Hasharon, Israel, whose mothers resided in suburbs where drinking water contained perchlorate ≤340 μg/L (very high exposure, n 97), 42–94 μg/L (high exposure, n 216), and <3 μg/L (low exposure, n 843). In the very high and high exposure areas, T4values in newborns whose mothers drank tap water exclusively (as determined by a telephone interview) were analyzed as a subset. Serum perchlorate levels in blood from donors residing in the area were used as proxy indicators of exposure. Main outcome: Neonatal T4values (mean ± SD) in the very high, high, and low exposure groups were 13.9 ± 3.8, 13.9 ± 3.4, and 14.0 ± 3.5 μg/dL, respectively (p NS). Serum perchlorate concentrations in blood from donors residing in areas corresponding to these groups were 5.99 ± 3.89, 1.19 ± 1.37, and 0.44 ± 0.55 μg/L, respectively. T4levels of neonates with putative gestational exposure to perchlorate in drinking water were not statistically different from controls. Conclusion: This study finds no change in neonatal T4levels despite maternal consumption of drinking water that contains perchlorate at levels in excess of the Environmental Protection Agency (EPA) drinking water equivalent level (24.5 μg/L) based on the National Research Council reference dose (RfD) 0.7 μg/(kg·day). Therefore the perchlorate RfD is likely to be protective of thyroid function in neonates of mothers with adequate iodide intake. [ABSTRACT FROM AUTHOR]
AB - Copyright of Thyroid is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THYROGLOBULIN
KW - MOTHERS
KW - NEWBORN infants
KW - ENVIRONMENTALISM
N1 - Accession Number: 27308693; Yona Amitai 1,2,3 Gary Winston 2,3,4 Joseph Sack 5 Janice Wasser 1,2,3 Matthew Lewis 2,3,6 Benjamin C. Blount 7 Liza Valentin-Blasini 7 Nirah Fisher 1,2,3 Avi Israeli 3 Alex Leventhal 2,3; Affiliation: 1: Department of Mother, Child, and Adolescent Health, Jerusalem, Israel. 2: Public Health Service, Jerusalem, Israel. 3: Ministry of Health, Jerusalem, Israel. 4: Department of Environmental Health, Jerusalem, Israel. 5: Department of Community Genetics, Sackler School of Medicine, Tel Aviv University, Jerusalem, Israel. 6: Tel Aviv Health District Office, Jerusalem, Israel. 7: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia.; Source Info: Sep2007, Vol. 17 Issue 9, p843; Subject Term: THYROGLOBULIN; Subject Term: MOTHERS; Subject Term: NEWBORN infants; Subject Term: ENVIRONMENTALISM; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lugovtsev, Vladimir Y.
AU - Vodeiko, Galina M.
AU - Strupczewski, Caryn M.
AU - Ye, Zhiping
AU - Levandowski, Roland A.
T1 - Generation of the influenza B viruses with improved growth phenotype by substitution of specific amino acids of hemagglutinin
JO - Virology
JF - Virology
Y1 - 2007/09//
VL - 365
IS - 2
M3 - Article
SP - 315
EP - 323
SN - 00426822
AB - Abstract: Variability in growth characteristics of influenza B viruses remains a serious limitation in the manufacture of inactivated influenza vaccines. Currently, serial passage in eggs is the strategy used in most instances for selection of high growth virus variants. In previous studies we found that adaptation of the strain B/Victoria/504/2000 to high growth in eggs was associated with changes only in hemagglutinin (HA). The high growth phenotype was associated with acquisition of either two (R162M and D196Y) or three (G141E, R162M and D196Y) amino acid (AA) substitutions, predicted to be near the receptor-binding domain of HA. In the present study we analyzed, using reverse genetics, the contribution to virus growth of each of these AA substitutions and determined their effect on antigenic properties. We found that G141E and R162M were most favorable for virus growth; however, only R162M could improve virus growth without antigenic alteration. Substitution D196Y had least effect on virus growth but substantially altered antigenic properties. Additional virus variants with AA substitutions at positions 126, 129, 137 and 141 were generated and characterized. The AA changes advantageous for growth of B/Victoria/504/2000 were also tested in the context of the HA of the B/Beijing/184/93, a virus with stable low-growth phenotype. All of the tested AA substitutions improved the replicative capabilities of the corresponding viruses, but only N126D and K129E had no effect on antigenicity. The results of our studies demonstrate that introduction of specific AA substitutions into viral HA can improve viral replicative efficiency while preserving the original antigenic properties. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - RESPIRATORY infections
KW - VIRUS diseases
KW - GENOTYPE-environment interaction
KW - Antigenic properties
KW - Growth characteristics
KW - Influenza B virus
KW - Reverse genetics
N1 - Accession Number: 26146440; Lugovtsev, Vladimir Y.; Email Address: vladimir.lugovtsev@fda.hhs.gov Vodeiko, Galina M. 1 Strupczewski, Caryn M. 1 Ye, Zhiping 1 Levandowski, Roland A.; Affiliation: 1: Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bldg. 29A, Room 1D22, Bethesda, MD 20892, USA; Source Info: Sep2007, Vol. 365 Issue 2, p315; Subject Term: VIRUSES; Subject Term: RESPIRATORY infections; Subject Term: VIRUS diseases; Subject Term: GENOTYPE-environment interaction; Author-Supplied Keyword: Antigenic properties; Author-Supplied Keyword: Growth characteristics; Author-Supplied Keyword: Influenza B virus; Author-Supplied Keyword: Reverse genetics; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2007.04.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakab, Ferenc
AU - Horváth, Győző
AU - Ferenczi, Emőke
AU - Sebők, Judit
AU - Varecza, Zoltán
AU - Szűcs, György
T1 - Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary
JO - Virus Research
JF - Virus Research
Y1 - 2007/09//
VL - 128
IS - 1/2
M3 - Article
SP - 149
EP - 152
SN - 01681702
AB - Abstract: Dobrava hantavirus (DOBV) belongs to the genus Hantavirus of the family Bunyaviridae, and is carried by yellow necked and striped field mice (Apodemus flavicollis and Apodemus agrarius), respectively. The aim of this study was to detect and genetically characterize new DOBV strains in rodents captured in the Transdanubian region of Hungary. Rodent corpses were dissected and lung tissues were used for hantavirus detection by SYBR Green-based real-time RT-PCR using specific primers located in the S-segment of the virus genome. A total of 22 captured animals of the Apodemus species were tested for the presence of DOBV. Three out of the 22 mice were positive. Phylogenetic and molecular sequence analyses showed that Hungarian DOBVs were most closely related to those viruses detected from A. agrarius mice in Slovenia. Based on our new data from the region we concluded that extended reservoir studies would be necessary in the future. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APODEMUS
KW - MICE
KW - MAMMALS
KW - HUNGARY
KW - Dobrava–Belgrade hantavirus
KW - Hungary
KW - Phylogenetic analysis
KW - Real-time RT-PCR
N1 - Accession Number: 26148150; Jakab, Ferenc 1,2; Email Address: jakabf@gamma.ttk.pte.hu Horváth, Győző 1 Ferenczi, Emőke 3 Sebők, Judit 4 Varecza, Zoltán 5 Szűcs, György 2; Affiliation: 1: Institute of Biology, University of Pécs, Pécs, Hungary 2: Baranya County Institute of State Public Health Service, Regional Laboratory of Virology, Pécs, Hungary 3: National Center for Epidemiology, Department of Viral Diagnostics, Reference Laboratory of Viral Zoonoses, Budapest, Hungary 4: 2nd Department of Medicine and Nephrology, University Hospital, Pécs, Hungary 5: Department of Immunology and Biotechnology, Faculty of Medicine, University of Pécs, Pécs, Hungary; Source Info: Sep2007, Vol. 128 Issue 1/2, p149; Subject Term: APODEMUS; Subject Term: MICE; Subject Term: MAMMALS; Subject Term: HUNGARY; Author-Supplied Keyword: Dobrava–Belgrade hantavirus; Author-Supplied Keyword: Hungary; Author-Supplied Keyword: Phylogenetic analysis; Author-Supplied Keyword: Real-time RT-PCR; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.virusres.2007.04.015
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Von Eschenbach, Andrew C.
T1 - Diminished Capacity.
JO - Vital Speeches of the Day
JF - Vital Speeches of the Day
Y1 - 2007/09//
VL - 73
IS - 9
M3 - Speech
SP - 400
EP - 404
PB - Pro Rhetoric, LLC
SN - 0042742X
AB - The article presents the speech "Can the FDA Assure the Safety and Security of the Nation's Food Supply?" given by Andrew C. Von Eschenbach, Commissioner of the U.S. Food and Drug Administration, in his testimony to the Oversight and Investigations Subcommittee of the House Committee on Energy and Commerce in Washington, D.C. on July 17, 2007, discussing his agency's measures to prevent outbreaks of food-borne illness, including reforms in the FDA's Office of Regulatory Affairs (ORA).
KW - FOODBORNE diseases
KW - PREVENTION
KW - UNITED States. Food & Drug Administration
KW - VON Eschenbach, Andrew C., 1941-
N1 - Accession Number: 26265180; Von Eschenbach, Andrew C. 1; Affiliation: 1: Commissioner of Food and Drug Administration, U.S., Department of Health and Human Services; Source Info: Sep2007, Vol. 73 Issue 9, p400; Subject Term: FOODBORNE diseases; Subject Term: PREVENTION; Company/Entity: UNITED States. Food & Drug Administration; People: VON Eschenbach, Andrew C., 1941-; Number of Pages: 5p; Document Type: Speech; Full Text Word Count: 4183
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-18116-001
AN - 2008-18116-001
AU - Gfroerer, Joseph C.
AU - Larson, Sharon L.
AU - Colliver, James D.
T1 - Drug use patterns and trends in rural communities.
JF - The Journal of Rural Health
JO - The Journal of Rural Health
JA - J Rural Health
Y1 - 2007///Fal 2007
VL - 23
IS - Suppl1
SP - 10
EP - 15
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0890-765X
SN - 1748-0361
AD - Gfroerer, Joseph C., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1015, Rockville, MD, US, 20857
N1 - Accession Number: 2008-18116-001. Partial author list: First Author & Affiliation: Gfroerer, Joseph C.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Drug Abuse; Rural Environments; Tobacco Smoking. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Fal 2007. Copyright Statement: National Rural Health Association. 2007.
AB - Context and Purpose: This study examines the prevalence of tobacco, alcohol, and illicit drug use among adolescents and adults in 3 types of counties: 'rural' (nonmetropolitan counties with urban population less than 20,000), 'urbanized nonmetropolitan' (nonmetropolitan counties with urban population 20,000 or higher), and 'metropolitan' (counties in metropolitan areas). Methods: Data from the 2002-2004 National Surveys on Drug Use and Health are used to compare residents of the 3 county types. Descriptive findings and a multivariate model of marijuana use among adolescents are presented by county type. Findings: Past year illicit drug use is generally similar among adolescents in rural, urbanized nonmetropolitan, and metropolitan counties, except that Ecstasy use is higher among youth in metropolitan and urbanized nonmetropolitan counties than rural counties, while rural youth have a higher prevalence of stimulant and methamphetamine use than metropolitan youth. Gender, race/ethnicity, and family income functioned differentially across the 3 county types as predictors of youth marijuana use during the past year. Rural adults had generally lower rates of illicit drug use than metropolitan adults, but adults in rural and urbanized nonmetropolitan areas had higher rates of methamphetamine use than those in metropolitan areas. Rural youth had a higher prevalence of past month use of tobacco and alcohol. Rural adults had higher rates of tobacco use but lower rates of alcohol use. Conclusions: This study dispels the notion that substance abuse is only an urban problem and provides information useful in developing and implementing interventions that consider the unique characteristics of rural residents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug use patterns
KW - alcohol drinking patterns
KW - rural communities
KW - tobacco smoking
KW - 2007
KW - Alcohol Drinking Patterns
KW - Drug Abuse
KW - Rural Environments
KW - Tobacco Smoking
KW - 2007
DO - 10.1111/j.1748-0361.2007.00118.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18116-001&site=ehost-live&scope=site
UR - Joe.Gfroerer@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00609-001
AN - 2008-00609-001
AU - Malitz, Faye E.
AU - Eldred, Lois
T1 - Evolution of the special projects of national significance prevention with HIV-infected persons seen in primary care settings initiative.
JF - AIDS and Behavior
JO - AIDS and Behavior
JA - AIDS Behav
Y1 - 2007/09//
VL - 11
IS - Suppl1
SP - S1
EP - S5
CY - Germany
PB - Springer
SN - 1090-7165
SN - 1573-3254
AD - Malitz, Faye E., HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, MD, US
N1 - Accession Number: 2008-00609-001. Partial author list: First Author & Affiliation: Malitz, Faye E.; HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS; AIDS Prevention; Behavior Therapy; HIV; Primary Health Care. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Sep, 2007.
AB - For many years, HIV prevention efforts focused primarily on reducing the risk of infection among HIV-uninfected individuals, concentrating on individuals who engage in high-risk sexual behavior and drug use. Considerably less attention was given to the needs of individuals already infected with HIV and to providing assistance in not transmitting to others. Since 2000, the Health Resources and Services Administration (HRSA) has engaged in a number of activities directed toward increasing prevention efforts addressing the needs of HIV-positive individuals. This special supplement details the implementation of behavioral prevention interventions in 10 of the 15 demonstration sites funded as part of the Prevention with Positives Initiative. HRSA also funded an evaluation center to conduct both quantitative and qualitative evaluations of the initiative. Baseline findings from these cross-site evaluations also are presented in this supplemental issue. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral prevention interventions
KW - HIV
KW - AIDS
KW - HIV prevention
KW - primary care
KW - 2007
KW - AIDS
KW - AIDS Prevention
KW - Behavior Therapy
KW - HIV
KW - Primary Health Care
KW - 2007
U1 - Sponsor: Health Resources and Services Administration, Special Projects of National Significance (SPNS). Recipients: No recipient indicated
DO - 10.1007/s10461-007-9252-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00609-001&site=ehost-live&scope=site
UR - fmalitz@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11127-001
AN - 2008-11127-001
AU - Breslow, Rosalind A.
AU - Falk, Daniel E.
AU - Fein, Sara B.
AU - Grummer-Strawn, Laurence M.
T1 - Alcohol consumption among breastfeeding women.
JF - Breastfeeding Medicine
JO - Breastfeeding Medicine
JA - Breastfeed Med
Y1 - 2007/09//
VL - 2
IS - 3
SP - 152
EP - 157
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1556-8253
SN - 1556-8342
AD - Breslow, Rosalind A., Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2860, Rockville, MD, US, 20892
N1 - Accession Number: 2008-11127-001. PMID: 17903101 Partial author list: First Author & Affiliation: Breslow, Rosalind A.; Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, US. Release Date: 20090518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Breast Feeding; Epidemiology; Human Females. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 2007.
AB - Purpose: To determine the prevalence of alcohol consumption among breastfeeding and non-breastfeeding women at 3 months postpartum. Methods: We analyzed the most recent data available, which were from the 1993–1994 Food and Drug Administration Infant Feeding Practices Study I, a longitudinal panel study of infant– mother pairs. Self-reported data on alcohol consumption were analyzed for 772 breastfeeding women and 776 non-breastfeeding women age ≥14 years. Results: At 3 months postpartum, 36% of breastfeeding women and 40% of non-breastfeeding women consumed alcohol (p = 0.09). In multinomial regression models adjusted for age, race, education, income, marital status, region, smoking, and alcohol consumption before and during pregnancy, breastfeeding women were significantly less likely than non-breastfeeding women to consume two drinks per week (p < 0.01), or equal to or more than three drinks per week (p < 0.01), but equally likely to consume one drink (p = 0.23). Conclusions: A substantial percentage of breastfeeding women consumed alcohol. Their infants may or may not have been exposed, as some women may have used alcohol avoidance strategies. Nationally representative data are needed on alcohol consumption and infant feeding practices among breastfeeding women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence
KW - alcohol consumption
KW - breastfeeding
KW - non breastfeeding women
KW - postpartum
KW - 2007
KW - Alcohol Abuse
KW - Breast Feeding
KW - Epidemiology
KW - Human Females
KW - 2007
DO - 10.1089/bfm.2007.0012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11127-001&site=ehost-live&scope=site
UR - rbreslow@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17828-009
AN - 2007-17828-009
AU - McKay, Colleen E.
AU - Pelletier, John R.
T1 - Health promotion in clubhouse programs: Needs, barriers, and current and planned activities.
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2007///Fal 2007
VL - 31
IS - 2
SP - 155
EP - 159
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - McKay, Colleen E., Program for Clubhouse Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2007-17828-009. PMID: 18018961 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: McKay, Colleen E.; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20071203. Correction Date: 20150803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Behavior; Health Promotion; Program Development. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Fal 2007.
AB - A survey was designed to obtain information concerning ways clubhouses affiliated with the International Center for Clubhouse Development (ICCD) promote practices that improve the physical health of members. This study examined perceptions of the need for health promotion interventions, current and planned health promotion practices, and barriers to change and program development. The mean number of health promotion activities ICCD clubhouses (N = 219) report providing was 5.24, SD = 2.42, range = 1 to 10. Despite barriers (e.g., cost), results indicate that every clubhouse responding to this survey offers at least one health promotion activity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - clubhouse programs
KW - needs
KW - barriers
KW - current activities
KW - planned activities
KW - 2007
KW - Health
KW - Health Behavior
KW - Health Promotion
KW - Program Development
KW - 2007
DO - 10.2975/31.2.2007.155.159
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17828-009&site=ehost-live&scope=site
UR - Colleen.McKay@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2013-03321-005
AN - 2013-03321-005
AU - Yarber, William L.
AU - Crosby, Richard A.
AU - Graham, Cynthia A.
AU - Sanders, Stephanie A.
AU - Arno, Janet
AU - Hartzell, Rose M.
AU - McBride, Kimberly
AU - Milhausen, Robin
AU - Brown, Lindsay
AU - Legocki, Laurie J.
AU - Payne, Martha
AU - Rothring, Alexis
T1 - Correlates of putting condoms on after sex has begun and of removing them before sex ends: A study of men attending an urban public STD clinic.
JF - American Journal of Men's Health
JO - American Journal of Men's Health
Y1 - 2007/09//
VL - 1
IS - 3
SP - 190
EP - 196
CY - US
PB - Sage Publications
SN - 1557-9883
SN - 1557-9891
AD - Yarber, William L., Indiana University, HPER 116, 1025 East Seventh Street, Bloomington, IN, US, 47405
N1 - Accession Number: 2013-03321-005. PMID: 19482797 Partial author list: First Author & Affiliation: Yarber, William L.; Indiana University, Bloomington, IN, US. Release Date: 20130429. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Condoms; Sexual Intercourse (Human); Sexual Risk Taking. Minor Descriptor: Sexually Transmitted Diseases. Classification: Sexual Behavior & Sexual Orientation (2980). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2007. Copyright Statement: Sage Publications. 2007.
AB - This study aimed to identify possible correlates of putting condoms on after sex has begun and taking them off before sex has ended among male patients of an urban, public sexually transmitted disease clinic. Participants responded to a questionnaire and were largely African American men, 18 to 35 years old, who had used a condom during penile-vaginal intercourse at least three times in the past 3 months. In controlled analyses, men who were not highly motivated to use condoms correctly were nearly twice as likely to put a condom on after sex had begun. Men who reported erection loss during sex were about twice as likely to remove condoms before sex ended. Men reporting difficulties with the fit and feel of condoms were 2.5 times more likely to remove condoms early. Identified correlates may be amenable to clinic-based education and counseling augmented by offering a variety of condom brands and sizes to patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sexually transmitted diseases
KW - condoms
KW - sexual intercourse
KW - 2007
KW - Condoms
KW - Sexual Intercourse (Human)
KW - Sexual Risk Taking
KW - Sexually Transmitted Diseases
KW - 2007
U1 - Sponsor: Rural Center for AIDS/STD Prevention. Other Details: Joint project of Indiana University, University of Colorado, and the University of Kentucky. Recipients: No recipient indicated
U1 - Sponsor: Indiana University, School of Health, Physical Education and Recreation, Office of the Associate Dean for Research, US. Recipients: No recipient indicated
DO - 10.1177/1557988307301276
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2013-03321-005&site=ehost-live&scope=site
UR - yarber@indiana.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16921-007
AN - 2008-16921-007
AU - Meng, Hongdao
AU - Wamsley, Brenda R.
AU - Eggert, Gerald M.
AU - Van Nostrand, Joan F.
T1 - Impact of a health promotion nurse intervention on disability and health care costs among elderly adults with heart conditions.
JF - The Journal of Rural Health
JO - The Journal of Rural Health
JA - J Rural Health
Y1 - 2007///Fal 2007
VL - 23
IS - 4
SP - 322
EP - 331
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0890-765X
SN - 1748-0361
AD - Meng, Hongdao, Graduate Program in Public Health, Department of Preventive Medicine, State University of New York at Stony Brook, HSC, Level 3, Rm071, Stony Brook, NY, US, 11794-8338
N1 - Accession Number: 2008-16921-007. PMID: 17868239 Partial author list: First Author & Affiliation: Meng, Hongdao; Department of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, NY, US. Other Publishers: Blackwell Publishing. Release Date: 20090928. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: American Public Health Association Annual Meeting, 2006, Boston, MA, US. Conference Note: A draft of this paper was presented at the aforementioned conference. Major Descriptor: Disabilities; Health Care Costs; Health Promotion; Nurses; Rural Environments. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Cognitive Performance Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Fal 2007. Copyright Statement: National Rural Health Association. 2007.
AB - Context: Patients with heart conditions in rural areas may have different responses to health promotion-disease Self-management interventions compared to their urban counterparts. Purpose: To estimate the impact of a multi-component health promotion nurse intervention on physical function and total health care expenditures among elderly adults with heart conditions and to examine the impact of rural residence on the intervention effect. Methods: We analyzed data on 281 community-living Medicare beneficiaries with heart conditions from the Medicare Primary and Consumer-Directed Care Demonstration (a randomized controlled trial). We estimated ordinary least squares (OLS) models to determine the effect of the intervention on the change in functional status and log-linear models to determine the impact of the intervention on total health care expenditures over a 2-year period. Results: The OLS models showed that the nurse intervention resulted in fewer impairments in Activities of Daily Living (ADL) (–0.307 on 0-6 scale, P = .055) at the end of 2 years. The effect of the intervention on ADL appeared to be stronger for rural than for urban participants (–0.490 vs –0.162, respectively). However, the difference was not statistically significant (P = .150). The effect of the intervention on Instrumental Activities of Daily Living (IADL) was not significant (P = .321). Average total health care expenditures were 6.5% ($1,981, 95% CI: –$8,048, $4,087) lower in the nurse group. Conclusions: The nurse intervention led to better physical functioning and has potential to reduce total health care expenditures among high-risk Medicare beneficiaries with heart conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - nurse intervention
KW - disability
KW - health care costs
KW - elderly adults
KW - rural areas
KW - 2007
KW - Disabilities
KW - Health Care Costs
KW - Health Promotion
KW - Nurses
KW - Rural Environments
KW - 2007
U1 - Sponsor: Health Resources and Services Administration. Grant: 05-S250-0368. Recipients: No recipient indicated
DO - 10.1111/jrh.2007.23.issue-410.1111/j.1748-0361.2007.00110.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16921-007&site=ehost-live&scope=site
UR - hongdao.meng@stonybrook.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18605-006
AN - 2007-18605-006
AU - Snowden, Lonnie R.
T1 - Explaining mental health treatment disparities: Ethnic and cultural differences in family involvement.
JF - Culture, Medicine and Psychiatry
JO - Culture, Medicine and Psychiatry
JA - Cult Med Psychiatry
Y1 - 2007/09//
VL - 31
IS - 3
SP - 389
EP - 402
CY - Germany
PB - Springer
SN - 0165-005X
SN - 1573-076X
AD - Snowden, Lonnie R., Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley, Berkeley, CA, US, 94720
N1 - Accession Number: 2007-18605-006. PMID: 17874177 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley, Berkeley, CA, US. Release Date: 20080317. Correction Date: 20161013. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Family; Mental Health Services; Minority Groups; Racial and Ethnic Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Adult Performance Outcome Survey; Quality of Life Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Sep, 2007.
AB - In a large, representative sample of persons receiving public mental health treatment, we examined whether ethnic minority consumers were more likely than white consumers to live with their families and to receive family support. We then evaluated whether differences observed in family involvement explained treatment disparities observed in outpatient and inpatient mental health services. Results indicated that Asian American and Latino consumers, especially, were considerably more likely than white consumers to live with family members and to receive family support. Ethnocultural differences in living with family did explain treatment intensity disparities whether or not consumers described themselves as dependent on family support. The results support the hypothesis that cultural differences in family involvement and support play a role in explaining mental health treatment disparities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health treatment disparities
KW - family involvement
KW - ethnic & cultural differences
KW - minority groups
KW - 2007
KW - Family
KW - Mental Health Services
KW - Minority Groups
KW - Racial and Ethnic Differences
KW - 2007
DO - 10.1007/s11013-007-9057-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18605-006&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-14158-001
AN - 2007-14158-001
AU - Pfefferle, Susan G.
T1 - Pediatrician perspectives on children's access to mental health services: Consequences and potential solutions.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2007/09//
VL - 34
IS - 5
SP - 425
EP - 434
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Pfefferle, Susan G., Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, 1 Brookings Dr., Campus Box 1093, St. Louis, MO, US, 63130
N1 - Accession Number: 2007-14158-001. PMID: 17436077 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Pfefferle, Susan G.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20071022. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: Academy Health Annual Research Meeting, Jun, 2005, Boston, MA, US. Conference Note: A previous version of this paper was presented as a poster at aforementioned conference, and the 19th Annual Research Conference: A System of Care: Expanding the Research Base, February 22-24, 2006. Major Descriptor: Health Personnel Attitudes; Mental Health Services; Pediatricians. Minor Descriptor: Consequence. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2007.
AB - This paper examines pediatricians' perspectives regarding access to children's mental health care. In response to a question about factors that help or hinder coordination of care 190 respondents voluminously wrote about mental health access barriers. Responses were qualitatively analyzed to understand pediatricians' perspectives. Four thematic areas emerged: Insurance issues; availability of mental health specialty providers; state mental health systems; and pediatricians' attempts to improve access to mental health services. Pediatricians' responses included educating themselves, using telemedicine, and hiring co-located mental health specialists. Recommendations are made to address pediatricians' treatment of children with mental illnesses and their access to treatment resources. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pediatrician's perspectives
KW - children
KW - access
KW - mental health services
KW - adolescents
KW - 2007
KW - Health Personnel Attitudes
KW - Mental Health Services
KW - Pediatricians
KW - Consequence
KW - 2007
U1 - Sponsor: Fahs-Back Fund for Research and Experimentation. Other Details: Dissertation grant. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P30 MH068579. Recipients: No recipient indicated
DO - 10.1007/s10488-007-0122-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-14158-001&site=ehost-live&scope=site
UR - spfefferle@gwbmail.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16745-003
AN - 2007-16745-003
AU - Ferguson, Sherry A.
AU - Paule, Merle G.
AU - Cada, Amy
AU - Fogle, C. Matthew
AU - Gray, Erika P.
AU - Berry, Kimberly J.
T1 - Baseline behavior, but not sensitivity to stimulant drugs, differs among Spontaneously Hypertensive, Wistar--Kyoto, and Sprague--Dawley rat strains.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2007/09//
VL - 29
IS - 5
SP - 547
EP - 561
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Ferguson, Sherry A., Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2007-16745-003. PMID: 17689921 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20080303. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cada, Amy. Major Descriptor: Animal Ethology; Attention Deficit Disorder with Hyperactivity; Drugs; Rats. Minor Descriptor: Animal Strain Differences. Classification: Social & Instinctive Behavior (2440); Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Sep, 2007.
AB - Deficits in temporal processing are implicated in Attention Deficit Hyperactivity Disorder (ADHD) for which the most common rodent model is the Spontaneously Hypertensive Rat (SHR). To assess strain differences in temporal processing, males and females of the SHR, Wistar-Kyoto (WKY), and Sprague-Dawley (SD) strains were compared on two timing tasks: one requiring maintenance of a lever press for 10-14 s (TRD, temporal response differentiation) and the other requiring withholding of a lever press for 10-14 s (DRL, differential reinforcement of low rates). Performance of the progressive ratio (PR) task more directly assessed food-motivated behavior. Strains did not differ in task acquisition; however, steady state TRD and DRL performance of the SHR and WKY strains was less accurate which was related to increased burst (non-timing related) responses in those strains relative to the SD. PR performance demonstrated that the SHR and WKY strains exhibited higher response rates and breakpoints than the SD. Subsequently, methylphenidate (1, 3.25, 4.50, 7.50, and 12.0 mg/kg) and D-amphetamine (0.1, 0.25, 0.65, 1.0, and 2.0 mg/kg) were administered intraperitoneally pre-testing. Both drugs disrupted TRD and DRL performances by increasing burst response frequency; however, the strains were not differentially sensitive to either drug. Strain differences were generally maintained throughout the drug and extinction portions of the study. These results indicate increased similarity between the SHR and WKY strains relative to the SD in performance of timing and motivation tasks. Further, the current results do not support continued use of the SHR as a model for ADHD. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Attention Deficit Hyperactivity Disorder
KW - baseline behavior
KW - Dawley rat strains
KW - drugs
KW - Spontaneously Hypertensive Rat
KW - 2007
KW - Animal Ethology
KW - Attention Deficit Disorder with Hyperactivity
KW - Drugs
KW - Rats
KW - Animal Strain Differences
KW - 2007
U1 - Sponsor: US Department of Energy/US Food and Drug Administration, Oak Ridge Institute for Science and Education, US. Other Details: Interagency agreement. Recipients: Cada, Amy; Gray, Erika P.; Berry, Kimberly J.
DO - 10.1016/j.ntt.2007.07.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16745-003&site=ehost-live&scope=site
UR - Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-15080-009
AN - 2007-15080-009
AU - Fekedulegn, Desta B.
AU - Andrew, Michael E.
AU - Burchfiel, Cecil M.
AU - Violanti, John M.
AU - Hartley, Tara A.
AU - Charles, Luenda E.
AU - Miller, Diane B.
T1 - Area under the curve and other summary indicators of repeated waking cortisol measurements.
JF - Psychosomatic Medicine
JO - Psychosomatic Medicine
Y1 - 2007/09//
VL - 69
IS - 7
SP - 651
EP - 659
CY - US
PB - Lippincott Williams & Wilkins
SN - 0033-3174
SN - 1534-7796
AD - Fekedulegn, Desta B., Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD/BEB, MS 4050, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2007-15080-009. PMID: 17766693 Partial author list: First Author & Affiliation: Fekedulegn, Desta B.; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Release Date: 20071022. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hydrocortisone; Hypothalamic Pituitary Adrenal Axis; Saliva; Stress; Wakefulness. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2007.
AB - Objective: To derive the area under the curve and related summary measures of stress from saliva samples collected over time and to provide insight into the interpretation of the derived parameters. In research designed to assess the health consequences of stress these samples are often used as a physiologic indicator of the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis. To make these repeated measurements of salivary cortisol more useful in defining the relationships between stress and health there is a need to derive two forms of area under the curve that summarize the measurements: area under the curve with respect to ground (AUCG) and area under the curve with respect to increase (AUCI). The latter parameters, AUCI, however, is seldom used by research scientists. Methods: In this study, interpretation and generic definition of the area under the curve was provided through graphical analyses and examination of its association with other summary measures using data from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Pilot Study. In generic form, AUCI is derived as the area under the curve above the baseline value minus the area above the curve below the baseline value. Results: The sign and magnitude of AUCI are related to the profile and the rate of change of the measurements over time. The parameter showed significant associations with other summary indicators that measure pattern or rate of change of the measurements over time. Conclusion: Principal components analyses revealed that summary parameters derived from repeated cortisol measurements can be grouped into two meaningful general categories: measures of the magnitude of response and measures of the pattern of response over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - repeated waking cortisol measurements
KW - saliva samples
KW - stress
KW - hypothalamic pituitary adrenal axis
KW - 2007
KW - Hydrocortisone
KW - Hypothalamic Pituitary Adrenal Axis
KW - Saliva
KW - Stress
KW - Wakefulness
KW - 2007
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: 200 to 2003 to 01580. Recipients: No recipient indicated
DO - 10.1097/PSY.0b013e31814c405c
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15080-009&site=ehost-live&scope=site
UR - djf7@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02557-001
AN - 2009-02557-001
AU - Gatz, Margaret
AU - Brounstein, Paul J.
AU - Noether, Chanson D.
T1 - Findings from a national evaluation of services to improve outcomes for women with co-occurring disorders and a history of trauma.
JF - Journal of Community Psychology
JO - Journal of Community Psychology
JA - J Community Psychol
Y1 - 2007/09//
VL - 35
IS - 7
SP - 819
EP - 822
CY - US
PB - John Wiley & Sons
SN - 0090-4392
SN - 1520-6629
AD - Gatz, Margaret, Department of Psychology, University of Southern California, Los Angeles, CA, US, 90089-1061
N1 - Accession Number: 2009-02557-001. Partial author list: First Author & Affiliation: Gatz, Margaret; Department of Psychology, University of Southern California, Los Angeles, CA, US. Release Date: 20090713. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Emotional Trauma; Treatment Outcomes; Violence. Minor Descriptor: Comorbidity; Human Females. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). References Available: Y. Page Count: 4. Issue Publication Date: Sep, 2007. Copyright Statement: Wiley Periodicals, Inc. 2007.
AB - In this special issue of the Journal of Community Psychology, the second of a two-part series, we have been allowed the opportunity to assemble articles on empirical findings from the Women, Co-Occurring Disorders and Violence Study (WCDVS). The WCDVS was a 5-year initiative jointly supported by the three centers of the Substance Abuse and Mental Health Services Administration (SAMHSA)—the Center for Substance Abuse Treatment (CSAT), the Center for Mental Health Services (CMSH), and the Center for Substance Abuse Prevention (CSAP)—to identify and evaluate comprehensive, integrated, trauma-informed service systems designed to address the needs of women with co-occurring disorders and a history of trauma. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment outcomes
KW - trauma-informed services
KW - co-occurring disorders
KW - women
KW - violence
KW - substance abuse treatment
KW - 2007
KW - Drug Rehabilitation
KW - Emotional Trauma
KW - Treatment Outcomes
KW - Violence
KW - Comorbidity
KW - Human Females
KW - 2007
U1 - Sponsor: US Public Health Service, US Department of Health and Human Services, US. Grant: TI 00-003. Other Details: Cooperative Agreement to Study Women With Alcohol, Drug Abuse and Mental Health (ADM) Disorders Who Have Histories of Violence: Phase II; Guidance for Applicants (GFA). Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Mental Health Services; Center for Substance Abuse Prevention. Date: from Mar, 2000. Recipients: No recipient indicated
DO - 10.1002/jcop.20183
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02557-001&site=ehost-live&scope=site
UR - gatz@usc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13303-010
AN - 2007-13303-010
AU - Straub, R. E.
AU - Lipska, B. K.
AU - Egan, M. F.
AU - Goldberg, T.. E.
AU - Callicott, J. H.
AU - Mayhew, M. B.
AU - Vakkalanka, R. K.
AU - Kolachana, B. S.
AU - Kleinman, J. E.
AU - Weinberger, D. R.
T1 - Allelic variation in GAD1 (GAD₆₇) is associated with schizophrenia and influences cortical function and gene expression.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2007/09//
VL - 12
IS - 9
SP - 854
EP - 869
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Straub, R. E., Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Clinical Center, Building 10, Room 4D18, MSC 1385, Bethesda, MD, US, 20892-1379
N1 - Accession Number: 2007-13303-010. PMID: 17767149 Partial author list: First Author & Affiliation: Straub, R. E.; Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20071105. Correction Date: 20160915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Gene Expression; Genes; Glutamic Acid; Prefrontal Cortex; Schizophrenia. Minor Descriptor: Genotypes; Nucleotides; Transferases. Classification: Genetics (2510); Schizophrenia & Psychotic States (3213). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Gordon Continuous Performance Task; Wechsler Memory Scale--Revised; California Verbal Learning Test DOI: 10.1037/t48844-000; WAIS-R (Wechsler Adult Intelligence Scale-Revised); Wide Range Achievement Test DOI: 10.1037/t49277-000; Wisconsin Card Sorting Test DOI: 10.1037/t31298-000; Structured Clinical Interview for DSM-IV. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Sep, 2007.
AB - Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD₆₇), encoded by GAD1, is found in schizophrenic post-mortem brain. We report evidence of distorted transmission of single-nucleotide polymorphism (SNP) alleles in two independent schizophrenia family-based samples. In both samples, allelic association was dependent on the gender of the affected offspring, and in the Clinical Brain Disorders Branch/National Institute of Mental Health (CBDB/NIMH) sample it was also dependent on catechol-O-methyltransferase (COMT) Val158Met genotype. Quantitative transmission disequilibrium test analyses revealed that variation in GAD1 influenced multiple domains of cognition, including declarative memory, attention and working memory. A 5′ flanking SNP affecting cognition in the families was also associated in unrelated healthy individuals with inefficient BOLD functional magnetic resonance imaging activation of dorsal prefrontal cortex (PFC) during a working memory task, a physiologic phenotype associated with schizophrenia and altered cortical inhibition, in addition, a SNP in the 5′ untranslated (and predicted promoter) region that also influenced cognition was associated with decreased expression of GAD1 mRNA in the PFC of schizophrenic brain. Finally, we observed evidence of statistical epistasis between two SNPs in COMT and SNPs in GAD1, suggesting a potential biological synergism leading to increased risk. These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gene expression
KW - allelic variations
KW - schizophrenia
KW - glutamic acid decarboxylase gene
KW - genotypes
KW - single nucleotide polymorphism
KW - catechol-O-methyltransferase
KW - prefrontal cortex
KW - 2007
KW - Gene Expression
KW - Genes
KW - Glutamic Acid
KW - Prefrontal Cortex
KW - Schizophrenia
KW - Genotypes
KW - Nucleotides
KW - Transferases
KW - 2007
U1 - Sponsor: National Institutes of Health, National Institute of Mental Health, Intramural Research Program. Recipients: No recipient indicated
DO - 10.1038/sj.mp.4001988
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13303-010&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1298-3334
UR -
UR - straubr@intra.nimh.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-15012-002
AN - 2007-15012-002
AU - Choi, Colleen S.
AU - Haynes, Suzanne
AU - Konsella, Laurie
AU - Goodman, Colleen
AU - Meltzer, Alfred
T1 - The Quick Health Data Online: The ultimate interactive database on recent trends in women's health.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2007/09//
VL - 16
IS - 7
SP - 941
EP - 958
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Choi, Colleen S., Office on Women's Health, Department of Health and Human Services, 200 Independence Avenue, SW, Room 730F, Washington, DC, US, 20201
N1 - Accession Number: 2007-15012-002. PMID: 17903071 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Choi, Colleen S.; Office on Women's Health, Department of Health and Human Services, Washington, DC, US. Release Date: 20080922. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Databases; Health; Human Females; Internet. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). References Available: Y. Page Count: 18. Issue Publication Date: Sep, 2007.
AB - A growing number of nonprofit and government agencies have developed interactive databases to help their website visitors and constituents obtain information about past and recent trends in healthcare. The Office on Women's Health of the Department of Health and Human Services has joined this pursuit by launching Quick Health Data Online (QHData), an interactive database providing health statistics that specifically pertain to women. Since its inception, QHData has quickly emerged as the leader in sophisticated and user-friendly interactive databases. What is so remarkable about QHData? This database is capable of generating health statistics by race (i.e., blacks, whites, Asian and Pacific Islanders, Hispanics, and Native Americans), gender, and age. The results can also be produced across different geographic levels--the nation, by region, state, and county; the jurisdiction statuses of the counties can also be identified as a border, frontier, metropolitan, urban, or rural. Users also have the flexibility of presenting the results in tables, bar graphs, and maps or exporting results to other processing or display tools. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Quick Health Data Online
KW - women's health
KW - interactive database
KW - 2007
KW - Databases
KW - Health
KW - Human Females
KW - Internet
KW - 2007
DO - 10.1089/jwh.2007.DH01
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15012-002&site=ehost-live&scope=site
UR - Colleen.Choi@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00609-004
AN - 2008-00609-004
AU - Myers, Janet J.
AU - Rose, Carol Dawson
AU - Shade, Starley B.
AU - Koester, Kimberly A.
AU - Maiorana, Andre
AU - Malitz, Faye
AU - Steward, Wayne T.
AU - Morin, Stephen F.
T1 - Sex, risk and responsibility: Provider attitudes and beliefs predict HIV transmission risk prevention counseling in clinical care settings.
JF - AIDS and Behavior
JO - AIDS and Behavior
JA - AIDS Behav
Y1 - 2007/09//
VL - 11
IS - Suppl1
SP - S30
EP - S38
CY - Germany
PB - Springer
SN - 1090-7165
SN - 1573-3254
AD - Myers, Janet J., Center for AIDS Prevention Studies, University of California, San Francisco, 50 Beale Street, Suite 1300, San Francisco, CA, US, 94105
N1 - Accession Number: 2008-00609-004. Partial author list: First Author & Affiliation: Myers, Janet J.; Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, CA, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; Disease Transmission; HIV; Risk Factors; Social Responsibility. Minor Descriptor: Caregivers; Clinics; Sex; Socioeconomic Class Attitudes. Classification: Immunological Disorders (3291). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2007.
AB - We examined factors associated with the frequency of HIV 'prevention with positives' (PwP) counseling delivered by providers participating in demonstration projects at 26 clinics. Three hundred and fifteen primary care and support service providers completed a survey assessing the frequency of PwP delivered at initial medical care visits and at regular care visits. Providers reported delivering PwP counseling to more patients at initial visits (67%) than to those returning for regular care (53%; t = 11.8, p < 0.001). During initial and regular care visits, providers reporting a sense of responsibility for conducting PwP and those regularly discussing the risk of reinfection with patients reported significantly more frequent PwP counseling. Providers expressing a belief that no matter how much counseling was delivered, some HIV-infected patients would still infect others (prevention fatalism) reported significantly less frequent counseling at all visits. To improve the quality and quantity of HIV PwP counseling, providers training should address attitudinal barriers and facilitators to counseling and the importance of addressing risk routinely. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - sex
KW - risk
KW - responsibility
KW - attitudes
KW - beliefs
KW - HIV transmission risk
KW - prevention
KW - clinical care
KW - HIV prevention with positives
KW - 2007
KW - AIDS Prevention
KW - Disease Transmission
KW - HIV
KW - Risk Factors
KW - Social Responsibility
KW - Caregivers
KW - Clinics
KW - Sex
KW - Socioeconomic Class Attitudes
KW - 2007
U1 - Sponsor: Health Resources and Services Administration, Special Projects of National Significance (SPNS). Grant: 5 H97 HA00261. Recipients: No recipient indicated
DO - 10.1007/s10461-007-9269-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00609-004&site=ehost-live&scope=site
UR - janet.myers@ucsf.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13705-001
AN - 2007-13705-001
AU - Basner, Mathias
AU - Fomberstein, Kenneth M.
AU - Razavi, Farid M.
AU - Banks, Siobhan
AU - William, Jeffrey H.
AU - Rosa, Roger R.
AU - Dinges, David F.
T1 - American time use survey: Sleep time and its relationship to waking activities.
JF - Sleep: Journal of Sleep and Sleep Disorders Research
JO - Sleep: Journal of Sleep and Sleep Disorders Research
JA - Sleep
Y1 - 2007/09//
VL - 30
IS - 9
SP - 1085
EP - 1095
CY - US
PB - American Academy of Sleep Medicine
SN - 0161-8105
SN - 1550-9109
AD - Basner, Mathias, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, US, 19104-6021
N1 - Accession Number: 2007-13705-001. PMID: 17910380 Other Journal Title: Sleep: Journal of Sleep Research & Sleep Medicine. Partial author list: First Author & Affiliation: Basner, Mathias; Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, US. Release Date: 20080204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Leisure Time; Lifestyle; Sleep; Sleep Wake Cycle. Minor Descriptor: Time Management. Classification: Physiological Processes (2540). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: American Time Use Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 2007.
AB - Study Objectives: To gain some insight into how various behavioral (lifestyle) factors influence sleep duration, by investigation of the relationship of sleep time to waking activities using the American Time Use Survey (ATUS). Design: Cross-sectional data from ATUS, an annual telephone survey of a population sample of US citizens who are interviewed regarding how they spent their time during a 24-hour period between 04:00 on the previous day and 04:00 on the interview day. Participants: Data were pooled from the 2003, 2004, and 2005 ATUS databases involving N = 47,731 respondents older than 14 years of age. Interventions: N/A Results: Adjusted multiple linear regression models showed that the largest reciprocal relationship to sleep was found for work time, followed by travel time, which included commute time. Only shorter than average sleepers (<7.5 h) spent more time socializing, relaxing, and engaging in leisure activities, while both short (<5.5 h) and long sleepers (≥8.5 h) watched more TV than the average sleeper. The extent to which sleep time was exchanged for waking activities was also shown to depend on age and gender. Sleep time was minimal while work time was maximal in the age group 45-54 yr, and sleep time increased both with lower and higher age. Conclusions: Work time, travel time, and time for socializing, relaxing, and leisure are the primary activities reciprocally related to sleep time among Americans. These activities may be confounding the frequently observed association between short and long sleep on one hand and morbidity and mortality on the other hand and should be controlled for in future studies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Time Use Survey
KW - sleep duration
KW - sleep time
KW - waking activities
KW - lifestyle
KW - time utilization
KW - leisure activities
KW - 2007
KW - Leisure Time
KW - Lifestyle
KW - Sleep
KW - Sleep Wake Cycle
KW - Time Management
KW - 2007
U1 - Sponsor: National Institutes of Health. Grant: NR-04281. Recipients: No recipient indicated
U1 - Sponsor: National Space Biomedical Research Institute. Grant: Cooperative Agreement NCC 9-58. Recipients: No recipient indicated
U1 - Sponsor: National Aeronautics and Space Administration. Grant: Cooperative Agreement NCC 9-58. Recipients: No recipient indicated
U1 - Sponsor: Institute for Experimental Psychiatry Research Foundation. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13705-001&site=ehost-live&scope=site
UR - basner@mail.med.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13292-016
AN - 2007-13292-016
AU - Laughren, Thomas
T1 - Wayne Fenton: Impact on Food and Drug Administration.
JF - Schizophrenia Bulletin
JO - Schizophrenia Bulletin
JA - Schizophr Bull
Y1 - 2007/09//
VL - 33
IS - 5
SP - 1153
EP - 1153
CY - United Kingdom
PB - Oxford University Press
SN - 0586-7614
SN - 1745-1701
AD - Laughren, Thomas
N1 - Accession Number: 2007-13292-016. PMID: 17578891 Partial author list: First Author & Affiliation: Laughren, Thomas; Division of Psychiatry Products, Food and Drug Administration, US. Other Publishers: National Institute of Mental Health. Release Date: 20071105. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinicians; Cognitions; Cognitive Impairment; Drug Therapy; Schizophrenia. Classification: Clinical Psychopharmacology (3340). Population: Human (10). Page Count: 1. Issue Publication Date: Sep, 2007.
AB - I had known about Wayne Fenton for a number of years before I had an opportunity to meet him. He had written several articles that I found quite interesting, and my wife, who is a psychiatric nurse, had met him and spoke very highly of him. He had been to her unit to recruit patients for studies, and she had some other contact with him involving patients he treated. The Measurement And Treatment Research to Improve Cognition in Schizophrenia (MATRICS) program was launched, and I finally met him in an introductory session on this program at Food and Drug Administration (FDA). He was there with others from National Institute of Mental Health (NIMH) and Steve Marder from University of California, Los Angeles. I think MATRICS has been a success, both in terms of defining a path forward in developing cognitive impairment in schizophrenia as a target for drug development and also as a model for government, industry, and academia to work together. After the MATRICS program was well on its way, my contacts with Wayne diminished. We did have some interactions on the negative symptoms program, and we were involved in a director's level meeting to generate ideas to stimulate new medications development over the following year. Then in September 2006, I remember getting the awful call from my wife about Wayne's tragic death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Wayne Fenton
KW - Food and Drug Administration
KW - medications development
KW - Measurement And Treatment Research to Improve Cognition in Schizophrenia
KW - 2007
KW - Clinicians
KW - Cognitions
KW - Cognitive Impairment
KW - Drug Therapy
KW - Schizophrenia
KW - 2007
DO - 10.1093/schbul/sbm073
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13292-016&site=ehost-live&scope=site
UR - thomas.laughren@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11888-005
AN - 2007-11888-005
AU - Peila, Rita
AU - Yucesoy, Berran
AU - White, Lon R.
AU - Johnson, Victor
AU - Kashon, Michael L.
AU - Wu, Kim
AU - Petrovitch, Helen
AU - Luster, Michael
AU - Launer, Lenore J.
T1 - A TGF-β1 polymorphism association with dementia and neuropathologies: The HAAS.
JF - Neurobiology of Aging
JO - Neurobiology of Aging
JA - Neurobiol Aging
Y1 - 2007/09//
VL - 28
IS - 9
SP - 1367
EP - 1373
CY - Netherlands
PB - Elsevier Science
SN - 0197-4580
AD - Peila, Rita, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C-309, Bethesda, MD, US, 20892-9205
N1 - Accession Number: 2007-11888-005. PMID: 16904244 Partial author list: First Author & Affiliation: Peila, Rita; Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, US. Release Date: 20071001. Correction Date: 20140519. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dementia; Genetics; Nerve Growth Factor; Neuropathology; Polymorphism. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Cognitive Abilities Screening Instrument DOI: 10.1037/t28521-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Sep, 2007.
AB - The transforming growth factor-β1 (TGF-β1) is involved in post-ischemic neuronal rescue and in β-amyloid turn-over. We hypothesized that the risk for dementia and related neuropathologies is modified by the TGF-β1 functional genetic variants. The association of the TGF-β1 + 29T → C polymorphism with dementia was examined in a sample of 261 cases and 491 controls from the Honolulu-Asia Aging Study, including 282 subjects with autopsy data. Dementia was assessed in 1991 and 1994 by a multi-step protocol and standardized diagnostic criteria. The analysis was adjusted for demographic and vascular factors. Compared to the TT genotype, the TC and the CC genotypes were associated with a reduced risk for vascular dementia (ORTC = 0.28, 95% confidence interval (CI): 0.1-0.9; ORCC = 0.28, CI: 0.1-0.9), microinfarcts (ORCC = 0.31, CI: 0.13-0.71) and cerebral amyloid angiopathy (ORCC = 0.48, CI: 0.2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (ORCC = 4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - transforming growth factor
KW - polymorphism
KW - dementia
KW - neuropathology
KW - genetic variants
KW - 2007
KW - Dementia
KW - Genetics
KW - Nerve Growth Factor
KW - Neuropathology
KW - Polymorphism
KW - 2007
U1 - Sponsor: National Institute on Aging. Grant: N01-AG-4-2149; UO1-AG-0-9349-03; RO1-AG-0-7155-06A1. Recipients: No recipient indicated
U1 - Sponsor: National Heart Lung and Blood Institute. Grant: N01-HC-0-5102. Recipients: No recipient indicated
U1 - Sponsor: Alzheimers Disease Association. Grant: 20303. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute on Aging. Other Details: Intramural Research Program. Recipients: No recipient indicated
U1 - Sponsor: National Institute for Environmental Health and Safety. Grant: Y1-ES-0001. Other Details: IAG. Recipients: No recipient indicated
DO - 10.1016/j.neurobiolaging.2006.06.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11888-005&site=ehost-live&scope=site
UR - peilar@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-11752-004
AN - 2007-11752-004
AU - Kong, Y.-K.
AU - Lowe, B. D.
AU - Lee, S.-J.
AU - Krieg, E. F.
T1 - Evaluation of handle design characteristics in a maximum screwdriving torque task.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2007/09//
VL - 50
IS - 9
SP - 1404
EP - 1418
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Lowe, B. D.
N1 - Accession Number: 2007-11752-004. PMID: 17654033 Partial author list: First Author & Affiliation: Kong, Y.-K.; Department of Systems Management Engineering, SungKyunKwan University, Suwon, Korea. Release Date: 20071022. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Engineering Psychology; Form and Shape Perception; Human Factors Engineering. Classification: Engineering & Environmental Psychology (4000). Population: Human (10); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Sep, 2007.
AB - The purpose of this study was to evaluate the effects of screwdriver handle shape, surface material and workpiece orientation on torque performance, finger force distribution and muscle activity in a maximum screwdriving torque task. Twelve male subjects performed maximum screw-tightening exertions using screwdriver handles with three longitudinal shapes (circular, hexagonal and triangular), four lateral shapes (cylindrical, double frustum, cone and reversed double frustum) and two surfaces (rubber and plastic). The average finger force contributions to the total hand force were 28.1%, 39.3%, 26.5% and 6.2%, in order from index to little fingers; the average phalangeal segment force contributions were 47.3%, 14.0%, 20.5% and 18.1% for distal, middle, proximal and metacarpal phalanges, respectively. The plastic surface handles were associated with 15% less torque output (4.86 Nm) than the rubber coated handles (5.73 Nm). In general, the vertical workpiece orientation was associated with higher torque output (5.9 Nm) than the horizontal orientation (4.69 Nm). Analysis of handle shapes indicates that screwdrivers designed with a circular or hexagonal cross-sectional shape result in greater torque outputs (5.49 Nm, 5.57 Nm), with less total finger force (95 N, 105 N). In terms of lateral shape, reversed double frustum handles were associated with less torque output (5.23 Nm) than the double frustum (5.44 Nm) and cone (5.37 Nm) handles. Screwdriver handles designed with combinations of circular or hexagonal cross-sectional shapes with double frustum and cone lateral shapes were optimal in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - handle design characteristics
KW - maximum screwdriving torque task
KW - screwdriver handle shape
KW - 2007
KW - Engineering Psychology
KW - Form and Shape Perception
KW - Human Factors Engineering
KW - 2007
DO - 10.1080/00140130701393775
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-11752-004&site=ehost-live&scope=site
UR - blowe@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13058-018
AN - 2007-13058-018
AU - Singh, Gopal K.
AU - Kogan, Michael D.
T1 - Widening socioeconomic disparities in US childhood mortality, 1969-2000.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/09//
VL - 97
IS - 9
SP - 1658
EP - 1665
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Singh, Gopal K., Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2007-13058-018. PMID: 17666705 Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20071217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mortality Rate; Socioeconomic Status; Trends. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2007.
AB - Objectives: We examined the extent to which area socioeconomic inequalities in overall and cause-specific mortality among US children aged 1-14 years changed between 1969 and 2000. Methods: We linked a census-based deprivation index to US county mortality data from 1969 to 2000. We used Poisson and log-linear regression and inequality indices to analyze temporal disparities. Results: Despite marked declines in child mortality, socioeconomic gradients (relative mortality risks) in overall child mortality increased substantially during the study period. During 1969-1971, children in the most deprived socioeconomic quintile had 52%, 13%, 69%, and 76% higher risks of all-cause, birth defect, unintentional injury, and homicide mortality, respectively, than did children in the least deprived socioeconomic quintile. The corresponding relative risks increased to 86%, 44%, 177%, 159%, respectively from 1998-2000. Conclusions: Dramatic reductions in mortality among children in all socioeconomic quintiles represent a major public health success. However, children in higher socioeconomic quintiles experienced much larger declines in overall, injury, and natural-cause mortality than did those in more deprived socioeconomic quintiles, which contributed to the widening socioeconomic gap in mortality. Widening disparities in child mortality may reflect increasing polarization among deprivation quintiles in material and social conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - widening socioeconomic disparities
KW - US childhood mortality
KW - 1969-2000
KW - 2007
KW - Mortality Rate
KW - Socioeconomic Status
KW - Trends
KW - 2007
DO - 10.2105/AJPH.2006.087320
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13058-018&site=ehost-live&scope=site
UR - gsingh@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13297-016
AN - 2007-13297-016
AU - Andrulis, Dennis P.
AU - Brach, Cindy
T1 - Integrating literacy, culture, and language to improve health care quality for diverse populations.
T3 - Health literacy
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2007/09//Sep-Oct, 2007
VL - 31
IS - Suppl1
SP - S122
EP - S133
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Andrulis, Dennis P., Drexel University School of Public Health, 1505 Race Street, 13th Floor, MS 660, Philadelphia, PA, US, 19102-1192
N1 - Accession Number: 2007-13297-016. Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Andrulis, Dennis P.; Center for Health Equality, Drexel University School of Public Health, Philadelphia, PA, US. Release Date: 20080204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cultural Sensitivity; Diversity; Health Care Services; Literacy; Quality of Care. Minor Descriptor: Health Education; Language Proficiency; Health Literacy. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: Sep-Oct, 2007.
AB - Objective: To understand the in terrelationship of literacy, culture, and language and the importance of addressing their intersection. Methods: Health literacy, cultural competence, and linguistic competence strategies to quality improvement were analyzed. Results: Strategies to improve health literacy or low-literate individuals are distinct from strategies for culturally diverse and individuals with limited English proficiency (LEP). The lack of integration results in health care that is unresponsive to some vulnerable groups' needs. A vision for integrated care is presented. Conclusion: Clinicians, the health care team, and health care organizations have important roles to play in addressing challenges related to literacy, culture, and language. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health literacy
KW - cultural competence
KW - linguistic competence
KW - health care quality
KW - diverse populations
KW - 2007
KW - Cultural Sensitivity
KW - Diversity
KW - Health Care Services
KW - Literacy
KW - Quality of Care
KW - Health Education
KW - Language Proficiency
KW - Health Literacy
KW - 2007
DO - 10.5993/AJHB.31.s1.16
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13297-016&site=ehost-live&scope=site
UR - dpa28@drexel.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ying Huang
AU - Ruqing Liu
AU - Zunyan Dai
AU - Anh-Nhan Pham
AU - Hojin Moon
AU - Jialong Fang
AU - Wolfgang Sadée
T1 - Chemogenomic Analysis Identifies Geldanamycins as Substrates and Inhibitors of ABCB1.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2007/09/02/
VL - 24
IS - 9
M3 - Article
SP - 1702
EP - 1712
SN - 07248741
AB - Abstract Purpose  A prerequisite for geldanamycin (GA, NSC122750) to targeting heat shock protein 90 and inhibiting tumor growth is sufficient intracellular drug accumulation. We hypothesized that membrane transporters on tumor cells determine at least in part the response to GA analogues. Materials and Methods  To facilitate a systematic study of chemosensitivity across a group of GA analogues with similar chemical structures, we correlated mRNA expression profiles of most known transporters with growth inhibitory potencies of compounds in 60 tumor cell lines (NCI-60). We subsequently validated the gene-drug correlations using cytotoxicity and transport assays. Results  Geldanamycin analogues displayed a range of negative correlations coefficients with ABCB1 (MDR1, or P-glycoprotein) expression. Suppressing ABCB1 in multidrug resistant cells (NCI/ADR-RES and K562/DOX) and ABCB1-transfected cells (BC19) increased sensitivity to GA analogues, as expected for substrates. Moreover, ABCB1-mediated efflux of daunorubicin in K562/DOX cells could be blocked markedly by GA analogues in a dose-dependent fashion. The IC50 values (half-maximum inhibition of daunorubicin efflux) were 5.5, 7.3 and 12 μM for macbecin II (NSC330500), 17-AAG (NSC330507) and GA, respectively. Conclusions  These observations demonstrate that GA analogues are substrates as well as inhibitors of ABCB1, suggesting that drug interactions between GA analogues and other agents that are ABCB1 substrates may occur via ABCB1 in normal or tumor cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER cells
KW - CELLS
KW - CELLULAR pathology
KW - ASCITES tumors
N1 - Accession Number: 26094839; Ying Huang 1 Ruqing Liu 2 Zunyan Dai 3 Anh-Nhan Pham 1 Hojin Moon 4 Jialong Fang 5 Wolfgang Sadée 3; Affiliation: 1: Western University of Health Sciences Department of Pharmaceutical Sciences, College of Pharmacy Pomona CA 91766 USA 2: Sun Yat-sen University School of Public Health Guangzhou China 3: The Ohio State University Program of Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center, College of Medicine and Public Health Columbus OH 43210 USA 4: National Center for Toxicological Research, Food and Drug Administration Division of Biometry and Risk Assessment Jefferson AR 72079 USA 5: National Center for Toxicological Research, Food and Drug Administration Division of Biochemical Toxicology Jefferson AR 72079 USA; Source Info: Sep2007, Vol. 24 Issue 9, p1702; Subject Term: CANCER cells; Subject Term: CELLS; Subject Term: CELLULAR pathology; Subject Term: ASCITES tumors; Number of Pages: 11p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26094839&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hudson, Julie L.
AU - Selden, Thomas M.
T1 - Children's Eligibility And Coverage: Recent Trends And A Look Ahead.
JO - Health Affairs
JF - Health Affairs
Y1 - 2007/09/03/Sep2007 Supplement
VL - 26
IS - 5
M3 - Article
SP - w618
EP - w629
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - We used data from the 1996-2005 Medical Expenditure Panel Survey to track changes in children's public insurance eligibility and coverage. During the 2001- 2005 "postexpansion" period, eligibility was approximately constant, while public enrollment increased rapidly and uninsurance declined. Nevertheless, as of 2005, 62 percent of all uninsured children (5.5 million) continued to be eligible but not enrolled. We present detailed estimates of their characteristics by age, income, race/ethnicity, health status, and nativity/citizenship. We also examine the impact of potential changes in SCHIP income thresholds-both an expansion and a rollback-and estimate the number and characteristics of the children potentially affected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - HEALTH education
KW - MEDICAID
KW - MEDICAL care costs
KW - HEALTH promotion
KW - MEDICAL informatics
KW - HUMAN services
KW - UNITED States
KW - STATE Children's Health Insurance Program (U.S.)
N1 - Accession Number: 34485088; Hudson, Julie L. 1; Email Address: jhudson@ahrq.gov Selden, Thomas M. 1; Affiliation: 1: Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, in Rockville, Maryland; Source Info: Sep2007 Supplement, Vol. 26 Issue 5, pw618; Subject Term: HEALTH; Subject Term: HEALTH education; Subject Term: MEDICAID; Subject Term: MEDICAL care costs; Subject Term: HEALTH promotion; Subject Term: MEDICAL informatics; Subject Term: HUMAN services; Subject Term: UNITED States; Company/Entity: STATE Children's Health Insurance Program (U.S.); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 12p; Document Type: Article
L3 - 10.1377/hlthaff.26.5.w618
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34485088&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C.Ö.
AU - Diamond, W.P.
AU - Schatzel, S.J.
T1 - Numerical analysis of the influence of in-seam horizontal methane drainage boreholes on longwall face emission rates
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2007/09/03/
VL - 72
IS - 1
M3 - Article
SP - 15
EP - 32
SN - 01665162
AB - Abstract: High methane emissions originating from the active face areas and from the fractured formations overlying and underlying the mined coalbed can adversely affect both safety and productivity in underground coal mines. Since ventilation alone may not be sufficient to control the methane levels in the longwall mining environment, gob gas ventholes have become a standard supplementary methane control option in many mines. As mines progress into deeper and gassier coalbeds, or as longwall panel size increases, ventilation and gob gas ventholes together may not be sufficient to maintain methane levels within statutory limits. To decrease the risk associated with methane emissions under these circumstances, in-seam horizontal methane drainage is often used to reduce the gas content of the coalbed prior to mining. Horizontal methane drainage borehole completion designs, drilling strategies, and degasification lead times may need to be adjusted for site-specific conditions due to mine design, geology, and the gas content of the coalbed. This study investigates different horizontal methane drainage borehole patterns, borehole lengths, and degasification times prior to and during panel extraction to evaluate their effectiveness in reducing methane emissions using a “dynamic” 3D reservoir modeling of a 381-m wide longwall panel operating in the Pittsburgh coalbed. Results of this study showed that dual and tri-lateral boreholes are more effective in decreasing emissions and in shielding the entries compared to fewer shorter, cross-panel, horizontal boreholes parallel to the longwall face. Modeling results showed that after 12 months of pre-mining methane drainage, the average longwall face emission rates can be reduced by as much as 10.3 m3/min and 6.8 m3/min using tri- and dual-lateral boreholes, respectively. It was also shown that if pre-mining methane drainage time is short, it is important to continue methane drainage during the panel extraction to maximize reductions in longwall face emissions since additional face emission reductions achieved during this period can be comparable to pre-mining degasification. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUMERICAL analysis
KW - METHANE
KW - EMISSIONS (Air pollution)
KW - COAL mines & mining
KW - In-seam horizontal boreholes
KW - Longwall mining
KW - Methane drainage
KW - Reservoir simulation
N1 - Accession Number: 26248163; Karacan, C.Ö.; Email Address: cok6@cdc.gov Diamond, W.P. 1 Schatzel, S.J. 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, Pittsburgh, PA 15236, USA; Source Info: Sep2007, Vol. 72 Issue 1, p15; Subject Term: NUMERICAL analysis; Subject Term: METHANE; Subject Term: EMISSIONS (Air pollution); Subject Term: COAL mines & mining; Author-Supplied Keyword: In-seam horizontal boreholes; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Methane drainage; Author-Supplied Keyword: Reservoir simulation; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.coal.2006.12.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26248163&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nordstrom, Jessica L.
AU - Vickery, Michael C. L.
AU - Blackstone, George M.
AU - Murray, Shelley L.
AU - DePaola, Angelo
T1 - Development of a Multiplex Real-Time PCR Assay with an Internal Amplification Control for the Detection of Total and Pathogenic Vibrio parahaemolyticus Bacteria in Oysters.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/09/15/
VL - 73
IS - 18
M3 - Article
SP - 5840
EP - 5847
SN - 00992240
AB - Vibrio parahaemolyticus is an estuarine bacterium that is the leading cause of shellfish-associated cases of bacterial gastroenteritis in the United States. Our laboratory developed a real-time multiplex PCR assay for the simultaneous detection of the thermolabile hemolysin ((tlh), thermostable direct hemolysin (tdh), and thermostable-related hemolysin (trh) genes of V. parahaemolyticus. The tlh gene is a species-specific marker, while the tdh and trh genes are pathogenicity markers. An internal amplification control (IAC) was incorporated to ensure PCR integrity and eliminate false-negative reporting. The assay was tested for specificity against >150 strains representing eight bacterial species. Only V. parahaemolyticus strains possessing the appropriate target genes generated a fluorescent signal, except for a late tdh signal generated by three strains of V. hollisae. The multiplex assay detected <10 CFU/reaction of pathogenic V. parahaemolyticus in the presence of >104 CFU/reaction of total V. parahaemolyticus bacteria. The real-time PCR assay was utilized with a most-probable-number format, and its results were compared to standard V. parahaernolyticus isolation methodology during an environmental survey of Alaskan oysters. The IAC was occasionally inhibited by the oyster matrix, and this usually corresponded to negative results for V. parahaemolyticus targets. V. parahaemolyticus tlh, tdh, and trh were detected in 44, 44, and 52% of the oyster samples, respectively. V. parahaemoiyticus was isolated from 33% of the samples, and tdh+ and trh+ strains were isolated from 19 and 26%, respectively. These results demonstrate the utility of the real-time PCR assay in environmental surveys and its possible application to outbreak investigations for the detection of total and pathogenic V. parahaemolyticus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO parahaemolyticus
KW - BIOLOGICAL assay
KW - GENE amplification
KW - PATHOGENIC microorganisms
KW - PATHOGENIC bacteria
KW - OYSTERS -- Contamination
KW - L-form bacteria -- Pathogenicity
KW - GASTROINTESTINAL diseases
KW - GENES
N1 - Accession Number: 26675324; Nordstrom, Jessica L. 1; Email Address: jessica.nordstrom@fda.hhs.gov Vickery, Michael C. L. 1 Blackstone, George M. 1 Murray, Shelley L. 2 DePaola, Angelo 1; Affiliation: 1: Gulf Coast Seafood Laboratory, Division of Seafood Science and Technology, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528 2: Alaska Department of Environmental Conservation Anchorage, Alaska 99501; Source Info: Sep2007, Vol. 73 Issue 18, p5840; Subject Term: VIBRIO parahaemolyticus; Subject Term: BIOLOGICAL assay; Subject Term: GENE amplification; Subject Term: PATHOGENIC microorganisms; Subject Term: PATHOGENIC bacteria; Subject Term: OYSTERS -- Contamination; Subject Term: L-form bacteria -- Pathogenicity; Subject Term: GASTROINTESTINAL diseases; Subject Term: GENES; Number of Pages: 8p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.00460-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Antonini, James M.
AU - Stone, Sam
AU - Roberts, Jenny R.
AU - Chen, Bean
AU - Schwegler-Berry, Diane
AU - Afshari, Aliakbar A.
AU - Frazer, David G.
T1 - Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/09/15/
VL - 223
IS - 3
M3 - Article
SP - 234
EP - 245
SN - 0041008X
AB - Abstract: Many welders have experienced bronchitis, metal fume fever, lung function changes, and an increase in the incidence of lung infection. Questions remain regarding the possible mechanisms associated with the potential pulmonary effects of welding fume exposure. The objective was to assess the early effects of stainless steel (SS) welding fume inhalation on lung injury, inflammation, and defense responses. Male Sprague–Dawley rats were exposed to gas metal arc-SS welding fume at a concentration of 15 or 40 mg/m3 ×3 h/day for 1, 3, or 10 days. The control group was exposed to filtered air. To assess lung defense responses, some animals were intratracheally inoculated with 5×104 Listeria monocytogenes 1 day after the last exposure. Welding particles were collected during exposure, and elemental composition and particle size were determined. At 1, 4, 6, 11, 14, and 30 days after the final exposure, parameters of lung injury (lactate dehydrogenase and albumin) and inflammation (PMN influx) were measured in the bronchoalveolar lavage fluid. In addition, particle-induced effects on pulmonary clearance of bacteria and macrophage function were assessed. SS particles were composed of Fe, Cr, Mn, and Ni. Particle size distribution analysis indicated the mass median aerodynamic diameter of the generated fume to be 0.255 μm. Parameters of lung injury were significantly elevated at all time points post-exposure compared to controls except for 30 days. Interestingly, no significant difference in lung PMNs was observed between the SS and control groups at 1, 4, and 6 days post-exposure. After 6 days post-exposure, a dramatic increase in lung PMNs was observed in the SS group compared to air controls. Lung bacteria clearance and macrophage function were reduced and immune and inflammatory cytokines were altered in the SS group. In summary, short-term exposure of rats to SS welding fume caused significant lung damage and suppressed lung defense responses to bacterial infection, but had a delayed effect on pulmonary inflammation. Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAINLESS steel
KW - WELDING fumes
KW - POISONOUS gases -- Toxicology
KW - OBSTRUCTIVE lung diseases
KW - Chromium
KW - Inflammation
KW - Inhalation
KW - Particulates
KW - Welding fume
N1 - Accession Number: 26473654; Antonini, James M.; Email Address: jga6@cdc.gov Stone, Sam 1 Roberts, Jenny R. 1 Chen, Bean 1 Schwegler-Berry, Diane 1 Afshari, Aliakbar A. 1 Frazer, David G. 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA; Source Info: Sep2007, Vol. 223 Issue 3, p234; Subject Term: STAINLESS steel; Subject Term: WELDING fumes; Subject Term: POISONOUS gases -- Toxicology; Subject Term: OBSTRUCTIVE lung diseases; Author-Supplied Keyword: Chromium; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Inhalation; Author-Supplied Keyword: Particulates; Author-Supplied Keyword: Welding fume; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.taap.2007.06.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26473654&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de Jesüs-Bonilla, Walleska
AU - Yiping Jia
AU - Alayash, Abdu I.
AU - Lopez-Garriga, Juan
T1 - The Heme Pocket Geometry of Lucina pectinata Hemoglobin II Restricts Nitric Oxide and Peroxide Entry: Model of Ligand Control for the Design of a Stable Oxygen Carrier.
JO - Biochemistry
JF - Biochemistry
Y1 - 2007/09/18/
VL - 46
IS - 37
M3 - Article
SP - 10451
EP - 10460
SN - 00062960
AB - Blood pressure elevation has been attributed in large part to the consumption of nitric oxide (NO) by extracellular hemoglobin (Hb) therapeutics following infusion in humans. We studied NO and hydrogen peroxide (H2O2) oxidative reaction kinetics of monomeric Hbs isolated from the clam Lucina pectinata to probe the effects of their distinctive heme pocket chemistries on ligand controls and heme oxidative stability. Hbl (Phe43(CD1), G1n64(E7), Phe29(B10), and Phe68(E11)) reacted with high avidity with NO (k′ox,NO = 91 μM-1 s-1), whereas HbII (Phe44(CD1), G1n65(E7), Tyr30(B10), and Phe69(E11)) reacted at a much slower rate (k′ox,NO = 2.8 μM-1 s-1). However, replacing B10 (Phe) by Tyr in recombinant Hbl (HbI PheB10Tyr) produced only a 2-fold reduction in the NO-induced oxidation rate (k′ox,NO = 49.9 μM-1 s-1). Among the clam Hbs, HbII exhibited the fastest NO dissociation and the slowest NO association with ferrous iron. Autoxidation, H2O2-mediated ferryl iron (FeIV) formation, and the subsequent heme degradation kinetics were much slower in HbII and HbI PheB10Tyr when compared to those of HbI. The Tyr(B10) residue appears to afford a greater heme oxidative stability advantage toward H2O2, whereas the close proximity of this residue together with Gln(E7) to the heme iron contributes largely to the distal control of NO binding. Engineering of second-generation Hb-based oxygen therapeutics that are resistant to NO/H2O2-driven oxidation may ultimately require further optimization of the heme pocket architecture to limit heme exposure to solvent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD pressure
KW - HEMOGLOBIN
KW - NITRIC oxide
KW - PEROXIDES
KW - LIGANDS
KW - BLOOD proteins
N1 - Accession Number: 26645989; de Jesüs-Bonilla, Walleska 1 Yiping Jia 2 Alayash, Abdu I. 2; Email Address: abdu.alayash@fda.hhs.gov Lopez-Garriga, Juan 1; Affiliation: 1: Department of Chemistry, Univeesity of Puerto Rico, Mayagüez Campus, P.O. Box 9019, Mayag#x00FC;ez 00681-9019. Puerto Rico 2: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20692; Source Info: 9/18/2007, Vol. 46 Issue 37, p10451; Subject Term: BLOOD pressure; Subject Term: HEMOGLOBIN; Subject Term: NITRIC oxide; Subject Term: PEROXIDES; Subject Term: LIGANDS; Subject Term: BLOOD proteins; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Hua-Jie
AU - Gong, Sheng-Ju
AU - Lin, Zhi-Xin
AU - Fu, Jian-Xi
AU - Xue, Song-Tao
AU - Huang, Jing-Chun
AU - Wang, Jin-Ye
T1 - In vivo biocompatibility and mechanical properties of porous zein scaffolds
JO - Biomaterials
JF - Biomaterials
Y1 - 2007/09/20/
VL - 28
IS - 27
M3 - Article
SP - 3952
EP - 3964
SN - 01429612
AB - Abstract: In our previous study, a three-dimensional zein porous scaffold with a compressive Young''s modulus of up to 86.6±19.9MPa and a compressive strength of up to 11.8±1.7MPa was prepared, and was suitable for culture of mesenchymal stem cells (MSCs) in vitro. In this study, we examined its tissue compatibility in a rabbit subcutaneous implantation model; histological analysis revealed a good tissue response and degradability. To improve its mechanical property (especially the brittleness), the scaffolds were prepared using the club-shaped mannitol as the porogen, and stearic acid or oleic acid was added. The scaffolds obtained had an interconnected tubular pore structure, 100–380μm in pore size, and about 80% porosity. The maximum values of the compressive strength and modulus, the tensile strength and modulus, and the flexural strength and modulus were obtained at the lowest porosity, reaching 51.81±8.70 and 563.8±23.4MPa; 3.91±0.86 and 751.63±58.85MPa; and 17.71±3.02 and 514.39±19.02MPa, respectively. Addition of 15% stearic acid or 20% oleic acid did not affect the proliferation and osteogenic differentiation of MSCs, and a successful improvement of mechanical properties, especially the brittleness of the zein scaffold could be achieved. [Copyright &y& Elsevier]
AB - Copyright of Biomaterials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCOMPATIBILITY
KW - BIOMEDICAL materials
KW - SCAFFOLDING
KW - BRITTLENESS
KW - Brittleness
KW - Fatty acid
KW - Mechanical properties
KW - Scaffold
KW - Subcutaneous implantation
KW - Zein
N1 - Accession Number: 25768079; Wang, Hua-Jie 1 Gong, Sheng-Ju 1 Lin, Zhi-Xin 1 Fu, Jian-Xi 2 Xue, Song-Tao 3,4 Huang, Jing-Chun 5 Wang, Jin-Ye 1,2; Email Address: jywang@mail.sioc.ac.cn; Affiliation: 1: College of Life Science and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China 2: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China 3: Research Institute of Structural Engineering and Disaster Reduction, Tongji University, Shanghai 200092, China 4: School of Science and Engineering, Kinki University, Osaka 577-8502, Japan 5: State Food and Drug Administration, Jinan Quality Supervision and Inspection Center for Medical Devices, The West End of Xinlou Road, H-T Industrial Development Zone, Jinan 250101, China; Source Info: Sep2007, Vol. 28 Issue 27, p3952; Subject Term: BIOCOMPATIBILITY; Subject Term: BIOMEDICAL materials; Subject Term: SCAFFOLDING; Subject Term: BRITTLENESS; Author-Supplied Keyword: Brittleness; Author-Supplied Keyword: Fatty acid; Author-Supplied Keyword: Mechanical properties; Author-Supplied Keyword: Scaffold; Author-Supplied Keyword: Subcutaneous implantation; Author-Supplied Keyword: Zein; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.biomaterials.2007.05.017
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Brayden, David J.
AU - Martinez, Marilyn N.
T1 - Prediction of therapeutic and drug delivery outcomes using animal models
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2007/09/30/
VL - 59
IS - 11
M3 - Editorial
SP - 1071
EP - 1072
SN - 0169409X
N1 - Accession Number: 27241106; Brayden, David J. 1; Email Address: david.brayden@ucd.ie Martinez, Marilyn N. 2; Email Address: MMartin1@cvm.fda.gov; Affiliation: 1: School of Agriculture Food Science and Veterinary Medicine University College Dublin Belfield, Dublin 4, Ireland 2: Center for Veterinary Medicine Food and Drug Administration Rockville, Maryland 208553 USA; Source Info: Sep2007, Vol. 59 Issue 11, p1071; Number of Pages: 2p; Document Type: Editorial
L3 - 10.1016/j.addr.2007.08.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yun-Peng Diao
AU - Yuan-Zhi Wang
AU - Ming-Dong Wang
AU - Kun Li
T1 - {1-[(2-Morpholin-4-ylethylimino-κ2 N, N′)methyl]naphthalen-2-olato-κ O}(thiocyanato- N)nickel(II).
JO - Acta Crystallographica: Section E (Wiley-Blackwell)
JF - Acta Crystallographica: Section E (Wiley-Blackwell)
Y1 - 2007/10//
VL - 63
IS - 10
M3 - Article
SP - m2494
EP - m2494
SN - 16005368
AB - In the title mononuclear nickel(II) complex, [Ni(C17H19N2O2)(NCS)], the NiII atom is four-coordinated by the phenolate O, imine N and amine N atoms of one Schiff base ligand, and by the terminal N atom of a thiocyanate ligand, forming a square-planar geometry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Crystallographica: Section E (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSICAL & theoretical chemistry
KW - NICKEL
KW - ORGANIC compounds
KW - ATOMS
KW - SCHIFF bases
KW - data-to-parameter ratio = 17.8
KW - mean σ(C-C) = 0.005 Å
KW - R factor = 0.063
KW - single-crystal X-ray study
KW - T = 298 K
KW - wR factor = 0.135
N1 - Accession Number: 27092983; Yun-Peng Diao 1; Email Address: diaoyiwen@126.com Yuan-Zhi Wang 2 Ming-Dong Wang 3 Kun Li 4; Affiliation: 1: School of Pharmacy, Dalian Medical University, Dalian 116027, People's Republic of China 2: Liaoning Food and Drug Administration, Shenyang 110003, People's Republic of China 3: Liaoning Food and Drug Administration Technical Evaluation Center, Shenyang 110003, People's Republic of China 4: College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People's Republic of China; Source Info: Oct2007, Vol. 63 Issue 10, pm2494; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: NICKEL; Subject Term: ORGANIC compounds; Subject Term: ATOMS; Subject Term: SCHIFF bases; Author-Supplied Keyword: data-to-parameter ratio = 17.8; Author-Supplied Keyword: mean σ(C-C) = 0.005 Å; Author-Supplied Keyword: R factor = 0.063; Author-Supplied Keyword: single-crystal X-ray study; Author-Supplied Keyword: T = 298 K; Author-Supplied Keyword: wR factor = 0.135; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 1p; Illustrations: 3 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1107/S1600536807043073
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ting-Kai Li
AU - Hewitt, Brenda G.
AU - Grant, Bridget F.
T1 - THE ALCOHOL DEPENDENCE SYNDROME, 30 YEARS LATER—A RESPONSE TO THE COMMENTARIES.
JO - Addiction
JF - Addiction
Y1 - 2007/10//
VL - 102
IS - 10
M3 - Article
SP - 1537
EP - 1538
PB - Wiley-Blackwell
SN - 09652140
AB - The author reflects on the commentary that discusses the issues pertaining alcohol dependence syndrome (ADS). It has been believed that the conceptual validity of the alcohol ADS has been demonstrated in both human and animal studies. With this, there is a rich literature on validation of the ADS in animal models and methods will be developed to measure alcohol exposures and responses in humans as well as we now do in animals. It has also been agreed upon that the need for longitudinal studies will establish predictive validity and dimensional criteria to ascertain severity and disease progression.
KW - ALCOHOLISM
KW - SUBSTANCE abuse
KW - ALCOHOL withdrawal syndrome
KW - DRINKING of alcoholic beverages
KW - DRUGS of abuse
KW - SOCIAL policy
KW - DISEASES -- Causes & theories of causation
KW - PUBLIC health
KW - GREAT Britain
N1 - Accession Number: 26516895; Ting-Kai Li 1 Hewitt, Brenda G. 1; Email Address: bhewitt@mail.nih.gov Grant, Bridget F. 1; Affiliation: 1: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA; Source Info: Oct2007, Vol. 102 Issue 10, p1537; Subject Term: ALCOHOLISM; Subject Term: SUBSTANCE abuse; Subject Term: ALCOHOL withdrawal syndrome; Subject Term: DRINKING of alcoholic beverages; Subject Term: DRUGS of abuse; Subject Term: SOCIAL policy; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: PUBLIC health; Subject Term: GREAT Britain; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/j.1360-0443.2007.02005.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choi, William
AU - Liang, Lan
AD - Econ One Research, Inc, Los Angeles, CA
AD - Agency for Healthcare Research and Quality, Rockville, MD
T1 - Reverse Moral Hazard of Liability Insurers: Evidence from Medical Malpractice Claims
JO - Applied Economics
JF - Applied Economics
Y1 - 2007/10//
VL - 39
IS - 16-18
SP - 2331
EP - 2340
SN - 00036846
N1 - Accession Number: 0952059; Keywords: Doctors; Liability; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200802
N2 - This study investigates putative differences in the legal defense of medical malpractice claims between liability carriers with distinct ownership forms: doctor-controlled and commercial-stock. The scope of a carrier's legal defense is determined by claim characteristics, such as injury severity and liability, and possibly the doctor's private costs from settling or losing a claim. When a carrier does not internalize the doctor's private costs from losing or settling a claim, then a conflict of interest arises as the carrier provides a lower level of legal defense than preferred by the doctor (i.e., reverse moral hazard). The perception is that doctor-sponsored carriers mitigate such conflicts of interest. If this is the case, we should expect to see differences in the amount spent by the carrier in defense of the doctor and the propensity to settle claims. To test these expectations, we use medical malpractice claims filed in Florida between 1985 and 1990. We indeed find differences in legal defense in terms of amount spent on legal defense and settlement rate between carriers with different ownership. The doctor-sponsored carrier we investigated was less likely to settle out-of-court, and did spend more on a doctor's legal defense than stock carriers.
KW - Insurance; Insurance Companies; Actuarial Studies G22
KW - Analysis of Health Care Markets I11
KW - Tort Law and Product Liability; Forensic Economics K13
L3 - http://www.tandfonline.com/loi/raec20
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UR - http://www.tandfonline.com/loi/raec20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Crawford, Ronald L.
AU - Jung, Carina M.
AU - Strap, Janice L.
T1 - The recent evolution of pentachlorophenol (PCP)-4-monooxygenase (PcpB) and associated pathways for bacterial degradation of PCP.
JO - Biodegradation
JF - Biodegradation
Y1 - 2007/10//
VL - 18
IS - 5
M3 - Article
SP - 525
EP - 539
SN - 09239820
AB - Man-made polychlorinated phenols such as pentachlorophenol (PCP) have been used extensively since the 1920s as preservatives to prevent fungal attack on wood. During this time, they have become serious environmental contaminants. Despite the recent introduction of PCP in the environment on an evolutionary time scale, PCP-degrading bacteria are present in soils worldwide. The initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase(PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone and is encoded by the pcpB gene. This review examines the literature concerning pcpB and supports the suggestion that pcpB/PcpB should be considered a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biodegradation is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biodegradation
KW - Fungus-bacterium relationships
KW - Prokaryotes
KW - Phenols
KW - Xenobiotics
KW - Enzymes
KW - Gene recruitment
KW - Lateral gene transfer
KW - PCP
KW - pcpB
KW - Pentachlorophenol
KW - Sphingomonas
N1 - Accession Number: 28809966; Crawford, Ronald L. 1; Email Address: crawford@uidaho.edu; Jung, Carina M. 1,2; Strap, Janice L. 1,3; Affiliations: 1: Environmental Biotechnology Institute, Food Research Center 202, University of Idaho, Moscow, ID 83844-1052, USA; 2: National Center for Toxicological Research, U.S. Food and Drug Administration, HFT-250, 3900 NCTR Road, Jefferson, AR 72079, USA; 3: Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street N, Oshawa, ON L1H 7K4, Canada; Issue Info: Oct2007, Vol. 18 Issue 5, p525; Thesaurus Term: Biodegradation; Thesaurus Term: Fungus-bacterium relationships; Thesaurus Term: Prokaryotes; Thesaurus Term: Phenols; Thesaurus Term: Xenobiotics; Subject Term: Enzymes; Author-Supplied Keyword: Gene recruitment; Author-Supplied Keyword: Lateral gene transfer; Author-Supplied Keyword: PCP; Author-Supplied Keyword: pcpB; Author-Supplied Keyword: Pentachlorophenol; Author-Supplied Keyword: Sphingomonas; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Karnaukhova, Elena
AU - Golding, Basil
AU - Ophir, Yakir
T1 - Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures
JO - Biologicals
JF - Biologicals
Y1 - 2007/10//
VL - 35
IS - 4
M3 - Article
SP - 285
EP - 295
SN - 10451056
AB - Abstract: Human alpha-1-proteinase inhibitor [1] Also known as antitrypsin. 1 (α1-PI) is the most abundant serine protease inhibitor in plasma. Its major function is inhibition of neutrophil elastase in lungs. α1-PI deficiency may result in severe, ultimately fatal emphysema. Three plasma-derived (pd-) α1-PI products are licensed in the US for replacement therapy of deficient patients. The recombinant versions (r-α1-PI), proposed as alternatives to pd-α1-PI products, have been under intensive investigation. For accurate determination of α1-PI from different sources and in various forms, there is an obvious need for reliable standardized assays for α1-PI quantification and potency measurements. As a part of our multi-step research focused on α1-PI structure-function investigation, we have established a simple and reproducible double-sandwich ELISA based on commercially available polyclonal antibodies. The developed ELISA allows the quantification of both pd-α1-PI and r-α1-PI in various complex matrices. A validation of the ELISA was performed with the working range of the assay (3.1–50ng/ml) established on the bases of the following parameters: linearity (3–100ng/ml, r 2 =0.995); accuracy (87.3–114.6% recovery); intra-assay precision (%CV, 2.8%); inter-assay plate-to-plate precision (3.9% per day and 4.1% day-to-day); detection limit (1.10ng/ml); and quantification limit (3.34ng/ml). The analytical performance of the α1-PI ELISA indicates that this assay can be used for monitoring concentration levels of α1-PI in multi-component biological matrices, based on the following: (a) quantification of r-α1-PI in various fermentation mixtures (E. coli and A. niger); (b) investigation of α1-PI enzymatically digested in the conditions of harsh fungal proteolysis; (c) evaluation of thermally polymerized α1-PI; (d) quantification of α1-PI in human serum; and (e) comparative quantification of α1-PI in commercially available products. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALPHA 1-antitrypsin
KW - TRYPSIN inhibitors
KW - ENZYME-linked immunosorbent assay
KW - BIOLOGICALS
KW - Alpha-1-proteinase inhibitor
KW - Antitrypsin
KW - ELISA
KW - Evaluation
N1 - Accession Number: 27139744; Karnaukhova, Elena; Email Address: elena.karnaukhova@fda.hhs.gov Golding, Basil 1 Ophir, Yakir 1; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA; Source Info: Oct2007, Vol. 35 Issue 4, p285; Subject Term: ALPHA 1-antitrypsin; Subject Term: TRYPSIN inhibitors; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: BIOLOGICALS; Author-Supplied Keyword: Alpha-1-proteinase inhibitor; Author-Supplied Keyword: Antitrypsin; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: Evaluation; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.biologicals.2006.11.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kiess, A. S.
AU - Kenney, P. B.
AU - Nayak, R. R.
T1 - Campylobacter detection in commercial turkeys.
JO - British Poultry Science
JF - British Poultry Science
Y1 - 2007/10//
VL - 48
IS - 5
M3 - Article
SP - 567
EP - 572
SN - 00071668
AB - 1. Frequency of Campylobacter detection was monitored in three flocks of turkeys. The effect of week of production was evaluated for hens in flocks 1 and 2, and the effect of week, gender and litter (fresh or used) was assessed for flock 3. 2. Gastrointestinal tracts, poult box liners, drinkers and faecal droppings were sampled. Conventional microbiological procedures were used to isolate and identify the presence of Campylobacter. Campylobacter latex agglutination tests were used for confirmation. 3. Peak colonisation occurred at approximately 3 weeks of production. Frequency of Campylobacter isolation from bird sources paralleled isolation from waterers. Frequency of detection from birds placed on used litter was lower than detection from birds placed on fresh litter (2% vs 58%). Gender did not affect frequency of detection. 4. Minimising peak colonisation at 3 weeks and managing litter are opportunities to reduce the occurrence of this organism in turkeys. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Poultry Science is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAMPYLOBACTER
KW - MICROORGANISMS -- Detection
KW - TURKEYS
KW - GASTROINTESTINAL system
KW - MICROBIOLOGY -- Technique
N1 - Accession Number: 27217228; Kiess, A. S. 1 Kenney, P. B. 2; Email Address: bkenney@wvu.edu Nayak, R. R. 3; Affiliation: 1: Department of Animal Science, Purdue University, West Lafayette, Indiana 2: Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, West Virginia 3: Microbiology Division, USFDA-National Center for Toxicological Research, Jefferson, Arkansas, USA; Source Info: Oct2007, Vol. 48 Issue 5, p567; Subject Term: CAMPYLOBACTER; Subject Term: MICROORGANISMS -- Detection; Subject Term: TURKEYS; Subject Term: GASTROINTESTINAL system; Subject Term: MICROBIOLOGY -- Technique; NAICS/Industry Codes: 112330 Turkey Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/00071660701573094
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yongsheng Yang
AU - Brownell, Charles
AU - Sadrieh, Nakissa
AU - May, Joan
AU - Del Grosso, Alfred
AU - Place, David
AU - Leutzinger, Eldon
AU - Duffy, Eric
AU - He, Ruyi
AU - Houn, Florence
AU - Lyon, Robbie
AU - Faustino, Patrick
T1 - Quantitative measurement of cyanide released from Prussian Blue.
JO - Clinical Toxicology (15563650)
JF - Clinical Toxicology (15563650)
Y1 - 2007/10//
VL - 45
IS - 7
M3 - Article
SP - 776
EP - 781
PB - Taylor & Francis Ltd
SN - 15563650
AB - Background. Prussian Blue (PB), ferric hexacyanoferrate is indicated for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide is 35-40% of PB's molecular composition, thus cyanide may be released during transit through the digestive tract under physiological pH. The U.S. Food and Drug Administration investigated the issue of cyanide release prior to drug approval to ensure the drug's benefits exceeded risks. Objectives. To determine cyanide released from PB under pH conditions that bracket human physiological exposure. Methods. PB was incubated in situ at pH 1.0-12, 37°C for 1-48 hours. Cyanide was measured using a validated colorimetric method by UV-VIS spectroscopy. Results. PB had the highest cyanide release at pH 1 (135 ug/g) and lowest release at pH 5.0-7.0 from the highest daily dose of PB (17.5 g) (21 ug/g). Considering the minimal lethal dose of cyanide is approximately 50 mg, the maximal cyanide released (1.6 mg) does not present a safety concern. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Toxicology (15563650) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CESIUM
KW - THALLIUM
KW - CYANIDES
KW - CALORIMETRY
KW - UNITED States
KW - Cyanide poisoning
KW - Prussian blue
KW - Quantitative
KW - Toxicity
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 27688904; Yongsheng Yang 1 Brownell, Charles 1 Sadrieh, Nakissa 2 May, Joan 3 Del Grosso, Alfred 3 Place, David 3 Leutzinger, Eldon 3 Duffy, Eric 3 He, Ruyi 4 Houn, Florence 3 Lyon, Robbie 1 Faustino, Patrick 1; Email Address: patrick.faustino@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research, Silver Spring, Maryland, USA 2: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Silver Spring, Maryland, USA 3: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Rockville, Maryland, USA 4: Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, Maryland, USA; Source Info: 2007, Vol. 45 Issue 7, p776; Subject Term: CESIUM; Subject Term: THALLIUM; Subject Term: CYANIDES; Subject Term: CALORIMETRY; Subject Term: UNITED States; Author-Supplied Keyword: Cyanide poisoning; Author-Supplied Keyword: Prussian blue; Author-Supplied Keyword: Quantitative; Author-Supplied Keyword: Toxicity; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 6p; Illustrations: 1 Diagram, 3 Graphs; Document Type: Article
L3 - 10.1080/15563650601181562
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cawley, John
AU - Meyerhoefer, Chad
AU - Newhouse, David
T1 - THE CORRELATION OF YOUTH PHYSICAL ACTIVITY WITH STATE POLICIES.
JO - Contemporary Economic Policy
JF - Contemporary Economic Policy
Y1 - 2007/10//
VL - 25
IS - 4
M3 - Article
SP - 506
EP - 517
PB - Wiley-Blackwell
SN - 10743529
AB - Childhood overweight has risen dramatically & the United States during the past three decades. The search for policy solutions is limited by a lack of evidence regarding the effectiveness of state policies for increasing physical activity among youths. This paper estimates the correlation of student physical activity with a variety of state policies. We study nationwide data on high school students from the Youth Risk Behavior Surveillance System for 1999, 2001, and 2003 merged with data on state policies from several sources. We control for a variety of characteristics of states and students to mitigate bias due to the endogenous selection of policies, but we conservatively interpret our results as correlations, not causal impacts. Two policies are positively correlated with participation in physical education (PE) class for both boys and girls: a binding PE unit requirement and a state PE curriculum. We also find that state spending on parks and recreation is positively correlated with two measures of girls' overall physical activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contemporary Economic Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY in children
KW - CHILDREN -- Health
KW - PHYSICAL education
KW - ATHLETICS
KW - EXERCISE
KW - EDUCATION & state
KW - UNITED States
N1 - Accession Number: 27555031; Cawley, John 1; Email Address: jhc38@cornell.edu; Meyerhoefer, Chad 2; Email Address: Chad.Meyerhoefer@ahrq.hhs.gov; Newhouse, David 3; Email Address: dnewhouse@imf.org; Affiliations: 1: Associate Professor, Department of Policy Analysis and Management, Cornell University, 124 MVR Hall, Ithaca, NY 14853; 2: Economist, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; 3: Technical Assistance Advisor, Poverty and Social Impact Analysis (PSIA) Group, Fiscal Affairs Department, International Monetary Fund, 700 19th St, NW, Washington DC 0431; Issue Info: Oct2007, Vol. 25 Issue 4, p506; Subject Term: OBESITY in children; Subject Term: CHILDREN -- Health; Subject Term: PHYSICAL education; Subject Term: ATHLETICS; Subject Term: EXERCISE; Subject Term: EDUCATION & state; Subject: UNITED States; NAICS/Industry Codes: 923110 Administration of Education Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 611620 Sports and Recreation Instruction; Number of Pages: 12p; Document Type: Article
L3 - 10.1111/j.1465-7287.2007.00070.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - McAdams, Mara
AU - Staffa, Judy A.
AU - Dal Pan, Gerald J.
T1 - The concomitant prescribing of ethinyl estradiol/drospirenone and potentially interacting drugs
JO - Contraception
JF - Contraception
Y1 - 2007/10//
VL - 76
IS - 4
M3 - Article
SP - 278
EP - 281
SN - 00107824
AB - Abstract: Background: Ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/DRSP) contains a progestin drospirenone with antimineralocorticoid properties that may cause potassium retention leading to hyperkalemia. We estimated the percentage of EE/DRSP users prescribed concomitant potassium-sparing drugs [nonsteroidal antiinflammatory drugs, diuretics, angiotensin-converting enzyme inhibitors (with diuretics), angiotensin II agonists (with diuretics), and potassium chloride] between January 1, 2002, and March 31, 2005. Study Design: We analyzed a population-based data set of 62,527 EE/DRSP users (Dimension Rx™, Caremark). We compared the fill date and end date for each prescription (Rx) for an interacting drug to the start and end date for each EE/DRSP episode (linked Rxs). If a day of an interacting Rx overlapped with an EE/DRSP episode, concomitant prescribing was recorded. Results: A total of 17.6% of the women concomitantly used EE/DRSP and an interacting drug. Twenty-nine percent of concomitant use occurred within a month of EE/DRSP initiation. Nonsteroidal antiinflammatory drugs and diuretics were most frequently used concomitantly with EE/DRSP. Forty percent of the women with concomitant use were 35 yearsof age or older at EE/DRSP initiation compared with 29% without concomitant use (p<.001). Obstetricians/gynecologists and family practitioners were the most common prescribers of EE/DRSP and potassium-sparing drugs, respectively. Conclusions: Concomitant prescribing of EE/DRSP and potassium-sparing drugs occurred frequently in our study population. As EE/DRSP becomes more widely used, physicians prescribing it should monitor patients for potassium-sparing drug use. [Copyright &y& Elsevier]
AB - Copyright of Contraception is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHINYL estradiol
KW - MEDICINE -- Formulae, receipts, prescriptions
KW - ANGIOTENSINS
KW - DIURETICS
KW - Concomitant treatment
KW - Drospirenone
KW - Hyperkalemia
KW - Oral contraceptive
KW - Potassium sparing
KW - Progestin
KW - Yasmin
N1 - Accession Number: 26840792; McAdams, Mara; Email Address: mara.mcadams@fda.hhs.gov Staffa, Judy A. 1 Dal Pan, Gerald J. 1; Affiliation: 1: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA; Source Info: Oct2007, Vol. 76 Issue 4, p278; Subject Term: ETHINYL estradiol; Subject Term: MEDICINE -- Formulae, receipts, prescriptions; Subject Term: ANGIOTENSINS; Subject Term: DIURETICS; Author-Supplied Keyword: Concomitant treatment; Author-Supplied Keyword: Drospirenone; Author-Supplied Keyword: Hyperkalemia; Author-Supplied Keyword: Oral contraceptive; Author-Supplied Keyword: Potassium sparing; Author-Supplied Keyword: Progestin; Author-Supplied Keyword: Yasmin; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.contraception.2007.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ittig, Peter T.
T1 - Higher Education Decisions.
JO - Decision Line
JF - Decision Line
J1 - Decision Line
PY - 2007/10//
Y1 - 2007/10//
VL - 38
IS - 5
M3 - Book Review
SP - 25
EP - 24
SN - 07326823
AB - The article reviews the book "A Test of Leadership: Charting the Future of U.S. Higher Education."
KW - TEST of Leadership: Charting the Future of US Higher Education, A (Book)
KW - HIGHER education -- United States
KW - LEADERSHIP
KW - NONFICTION
N1 - Accession Number: 27765243; Source Information: Oct2007, Vol. 38 Issue 5, p25; Subject Term: TEST of Leadership: Charting the Future of US Higher Education, A (Book); Subject Term: HIGHER education -- United States; Subject Term: LEADERSHIP; Subject Term: NONFICTION; Subject Term: ; Number of Pages: 4p; ; Document Type: Book Review;
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DP - EBSCOhost
DB - mth
ER -
TY - JOUR
AU - Thomas, John Terrig
AU - Moos, Malcolm
T1 - Vg1 has specific processing requirements that restrict its action to body axis patterning centers
JO - Developmental Biology
JF - Developmental Biology
Y1 - 2007/10//
VL - 310
IS - 1
M3 - Article
SP - 129
EP - 139
SN - 00121606
AB - Abstract: Unlike most transforming growth factor-β (TGF-β) superfamily members, Vg1 has been shown not to produce gross phenotypic alterations in Xenopus embryos when overexpressed by mRNA injection. Experiments with artificial chimeric constructs and a recently identified second allele of Vg1 suggest that this may be due to unusually stringent requirements for proteolytic processing. We provide biological and biochemical evidence that cleavage by two distinct proteolytic enzymes is required for effective activation of Vg1. We demonstrate a tightly restricted overlap in expression patterns of Vg1 with the proteases required to release the mature peptide. The data presented may account for the long-standing observation that the vast majority of Vg1 protein, in vivo, is present in its unprocessed form. Taken together, these observations provide a plausible mechanism for local action of Vg1 consistent with requirements imposed by current models of pattern formation in the developing body axis. [Copyright &y& Elsevier]
AB - Copyright of Developmental Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOLYTIC enzymes
KW - GROWTH factors
KW - DEVELOPMENTAL biology
KW - MESSENGER RNA
KW - BMP processing
KW - Mesoderm formation
KW - Proprotein convertases
KW - Vg1
N1 - Accession Number: 26822684; Thomas, John Terrig 1; Email Address: john.thomas@fda.hhs.gov Moos, Malcolm; Email Address: malcolm.moos@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, 20892, USA; Source Info: Oct2007, Vol. 310 Issue 1, p129; Subject Term: PROTEOLYTIC enzymes; Subject Term: GROWTH factors; Subject Term: DEVELOPMENTAL biology; Subject Term: MESSENGER RNA; Author-Supplied Keyword: BMP processing; Author-Supplied Keyword: Mesoderm formation; Author-Supplied Keyword: Proprotein convertases; Author-Supplied Keyword: Vg1; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ydbio.2007.07.032
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bagnyukova, Tetyana V.
AU - Luzhna, Lidia I.
AU - Pogribny, Igor P.
AU - Lushchak, Volodymyr I.
T1 - Oxidative Stress and Antioxidant Defenses in Goldfish Liver in Response to Short-Term Exposure to Arsenite.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/10//
VL - 48
IS - 8
M3 - Article
SP - 658
EP - 665
SN - 08936692
AB - The article presents a study that examines the effects of exposure to sodium arsenite on the glutathione pool, lipid peroxidation, protein carbonyl levels, global DNA methylation and activities of antioxidant enzymes in goldfish livers. It is revealed that oxidized glutathione and oxidative stress increased after four days, but that glutathione synthesis decreased both parameters after seven days. The research suggests that goldfish livers can cope with arsenic-induced oxidative stress mainly through adaptive changes in the glutathione and antioxidant enzymes.
KW - Goldfish
KW - Sodium
KW - Glutathione
KW - DNA
KW - Oxidative stress
KW - Enzymes
KW - Antioxidants
KW - Liver
KW - Lipids
KW - antioxidant enzymes
KW - arsenic
KW - DNA methylation
KW - fish
KW - glutathione
KW - oxidative stress
N1 - Accession Number: 27589228; Bagnyukova, Tetyana V. 1,2; Email Address: Tetyana.Bagnyukova@fda.hhs.gov; Luzhna, Lidia I. 1; Pogribny, Igor P. 2; Lushchak, Volodymyr I. 1; Email Address: lushchak@pu.if.ua. na; Affiliations: 1: Department of Biochemistry, Precarpathian National University, Ivano-Frankivsk, Ukraine; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; Issue Info: Oct2007, Vol. 48 Issue 8, p658; Thesaurus Term: Goldfish; Thesaurus Term: Sodium; Subject Term: Glutathione; Subject Term: DNA; Subject Term: Oxidative stress; Subject Term: Enzymes; Subject Term: Antioxidants; Subject Term: Liver; Subject Term: Lipids; Author-Supplied Keyword: antioxidant enzymes; Author-Supplied Keyword: arsenic; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: fish; Author-Supplied Keyword: glutathione; Author-Supplied Keyword: oxidative stress; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1002/em.20328
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cederroth, Christopher R.
AU - Vinciguerra, Manlio
AU - Kühne, Françoise
AU - Madani, Rime
AU - Doerge, Daniel R.
AU - Visser, Theo J.
AU - Foti, Michelangelo
AU - Rohner-Jeanrenaud, Françoise
AU - Vassalli, Jean-Dominique
AU - Nef, Serge
T1 - A Phytoestrogen-Rich Diet Increases Energy Expenditure and Decreases Adiposity in Mice.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/10//
VL - 115
IS - 10
M3 - Article
SP - 1467
EP - 1473
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Obesity is an increasingly prevalent health problem, and natural effective therapeutic approaches are required to prevent its occurrence. Phytoestrogens are plant-derived compounds with estrogenic activities; they can bind to both estrogen receptors α and β and mimic the action of estrogens on target organs. OBJECTIVES: The purpose of this study was to examine the influence of soy-derived phytoestrogens on energy balance and metabolism. METHODS: Male outbred mice (CD-1) were allowed ad libitum access to either a high soy-containing diet or a soy-free diet from conception to adulthood. We measured circulating serum isoflavone levels using reverse-phase solid-phase extraction for subsequent liquid chromatography electrospray tandem mass spectrometry analysis. Adult animals were analyzed for body composition by dualenergy X-ray absorptiometry, locomotor activity by running-wheel experiments, respiratory exchange rate by indirect calorimetry, and food intake using metabolic cages. Quantitative reverse transcriptase-polymerase chain reaction was performed to determine the expression of hypothalamic neuropeptide genes. RESULTS: We found that adult mice fed a soy-rich diet had reduced body weight, adiposity, and resistance to cold. This lean phenotype was associated with an increase in lipid oxidation due to a preferential use of lipids as fuel source and an increase in locomotor activity. The modulation of energy balance was associated with a central effect of phytoestrogens on the expression of hypothalamic neuropeptides, including agouti-related protein. CONCLUSION: The data suggest that dietary soy could have beneficial effects on obesity, but they also emphasize the importance of monitoring the phytoestrogen content of diets as a parameter of variability in animal experiments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Mice
KW - Soyfoods
KW - Nutrition
KW - Spectrum analysis
KW - Liquid chromatography
KW - Phytoestrogens
KW - Prevention of obesity
KW - Body weight
KW - Polymerase chain reaction
KW - Calorimetry
KW - AgRP
KW - endocrine disruptors
KW - isoflavones
KW - lipid oxidation
KW - obesity
KW - phytoestrogens
N1 - Accession Number: 27024384; Cederroth, Christopher R. 1; Vinciguerra, Manlio 2; Kühne, Françoise 1; Madani, Rime 1; Doerge, Daniel R. 3; Visser, Theo J. 4; Foti, Michelangelo 2; Rohner-Jeanrenaud, Françoise 2,5; Vassalli, Jean-Dominique 1; Nef, Serge 1; Email Address: Serge.Nef@medecine.unige.ch; Affiliations: 1: Department of Genetic Medicine and Development and National Center for Competence in Research - Frontiers in Genetics.; 2: Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; 3: National Center for Toxicological Research, Jefferson, Arkansas, USA.; 4: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; 5: Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Issue Info: Oct2007, Vol. 115 Issue 10, p1467; Thesaurus Term: RESEARCH; Thesaurus Term: Mice; Thesaurus Term: Soyfoods; Thesaurus Term: Nutrition; Thesaurus Term: Spectrum analysis; Thesaurus Term: Liquid chromatography; Subject Term: Phytoestrogens; Subject Term: Prevention of obesity; Subject Term: Body weight; Subject Term: Polymerase chain reaction; Subject Term: Calorimetry; Author-Supplied Keyword: AgRP; Author-Supplied Keyword: endocrine disruptors; Author-Supplied Keyword: isoflavones; Author-Supplied Keyword: lipid oxidation; Author-Supplied Keyword: obesity; Author-Supplied Keyword: phytoestrogens; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Arthur L.
AU - Stipe, Christopher B.
AU - Habjan, Matthew C.
AU - Ahlstrand, Gilbert G.
T1 - Role of Lubrication Oil in Particulate Emissions from a Hydrogen-Powered Internal Combustion Engine.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2007/10//
VL - 41
IS - 19
M3 - Article
SP - 6828
EP - 6835
SN - 0013936X
AB - Recent studies suggest that trace metals emitted by internal combustion engines are derived mainly from combustion of lubrication oil. This hypothesis was examined by investigation of the formation of particulate matter emitted from an internal combustion engine in the absence of fuel-derived soot. Emissions from a modified CAT 3304 diesel engine fueled with hydrogen gas were characterized. The role of organic carbon and metals from lubrication oil on particle formation was investigated under selected engine conditions. The engine produced exhaust aerosol with log normal-size distributions and particle concentrations between 105 and 107 cm-3 with geometric mean diameters from 18 to 31 nm. The particles contained organic carbon, little or no elemental carbon, and a much larger percentage of metals than particles from diesel engines. The maximum total carbon emission rate was estimated at 1.08 g h-1, which is much lower than the emission rate of the original diesel engine. There was also evidence that less volatile elements, such as iron, self-nucleated to form nanoparticles, some of which survive the coagulation process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Emissions (Air pollution)
KW - Hydrogen cars
KW - Internal combustion engines
KW - Lubrication & lubricants
KW - Combustion engineering
KW - Scientific method
KW - Diesel motors
KW - Coagulation
N1 - Accession Number: 27049142; Miller, Arthur L. 1; Email Address: ALMiller@cdc.gov; Stipe, Christopher B. 2; Habjan, Matthew C. 1,3; Ahlstrand, Gilbert G. 4; Affiliations: 1: National Institute for Occupational Safety and Health, Spokane, Washington 99207; 2: Mechanical Engineering Department, Seattle University, Seattle, Washington 98122; 3: Mechanical Engineering Department, Gonzaga University, Spokane, Washington 99258; 4: College of Biological Sciences Imaging Center, University of Minnesota, St. Paul, Minnesota 55108; Issue Info: Oct2007, Vol. 41 Issue 19, p6828; Thesaurus Term: Air pollution; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Hydrogen cars; Thesaurus Term: Internal combustion engines; Subject Term: Lubrication & lubricants; Subject Term: Combustion engineering; Subject Term: Scientific method; Subject Term: Diesel motors; Subject Term: Coagulation; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; NAICS/Industry Codes: 336310 Motor Vehicle Gasoline Engine and Engine Parts Manufacturing; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 324191 Petroleum Lubricating Oil and Grease Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105825331
T1 - A community outbreak of Campylobacter jejuni infection from a chlorinated public water supply.
AU - Richardson G
AU - Thomas DR
AU - Smith RM
AU - Nehaul L
AU - Ribeiro CD
AU - Brown AG
AU - Salmon RL
Y1 - 2007/10//
N1 - Accession Number: 105825331. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Campylobacter Infections -- Epidemiology
KW - Campylobacter
KW - Disease Outbreaks
KW - Water Microbiology
KW - Water Supply
KW - Campylobacter Infections -- Etiology
KW - Campylobacter Infections -- Microbiology
KW - Diarrhea -- Microbiology
KW - Questionnaires
KW - Retrospective Design
KW - Wales
KW - Human
SP - 1151
EP - 1158
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 135
IS - 7
PB - Cambridge University Press
AB - An outbreak of Campylobacter jejuni infection occurred in a South Wales Valleys housing estate. Illness in estate residents was associated with tap water consumption [population attributable risk (PAR) 50%, relative risk (RR) 2.53, 95% confidence interval (CI) 1.9-3.37] and residence in the upper estate (PAR 49%, RR 2.44, 95% CI 1.83-3.24). Amongst upper estate residents, rates of diarrhoeal illness increased with rates of water consumption (OR 18, 95% CI 3.5-92.4 for heaviest consumers, chi2 trend P<0.0001). The upper estate received mains water via a covered holding reservoir. A crack in the wall of the holding reservoir was identified. Contamination with surface water from nearby pasture land was the likely cause of this outbreak. Service reservoirs are common in rural communities and need regular maintenance and inspection. The role of water in sporadic cases of campylobacter enteritis may be underestimated.
SN - 0950-2688
AD - National Public Health Service, Communicable Disease Surveillance Centre, Cardiff, UK.
U2 - PMID: 17288640.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Andrès, Emmanuel
AU - Vidal-Alaball, Josep
AU - Federici, Laure
AU - Loukili, Noureddine Henoun
AU - Zimmer, Jacques
AU - Kaltenbach, Georges
T1 - Clinical aspects of cobalamin deficiency in elderly patients. Epidemiology, causes, clinical manifestations, and treatment with special focus on oral cobalamin therapy
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
Y1 - 2007/10//
VL - 18
IS - 6
M3 - Article
SP - 456
EP - 462
SN - 09536205
AB - Abstract: The aim of this work was to review the literature concerning cobalamin deficiency in elderly patients. Articles were identified through searches of PubMed–MEDLINE (January 1990 to June 2006), restricted to: English and French language, human subjects, elderly patients (>65 years), clinical trial, review and guidelines. Additional unpublished data from our cohort with cobalamin deficiency at the University Hospital of Strasbourg, France, were also considered. All of the papers and abstracts were reviewed by at least two senior researchers who selected the data used in the study. In elderly people, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. The recently identified food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or from its binding proteins. This syndrome is usually the consequence of atrophic gastritis, related or not to Helicobacter pylori infection, and of the long-term ingestion of antacids and biguanides (in around 60% of the patients). Management of cobalamin deficiency has been well established with the use of cobalamin injections. However, new routes of cobalamin administration (oral and nasal) are currently being developed, especially the use of oral cobalamin therapy to treat food-cobalamin malabsorption. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Internal Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases -- Transmission
KW - MEDICAL literature
KW - MEDICAL research
KW - INTERNET in medicine
KW - Cobalamin
KW - Cobalamin deficiency
KW - Elderly patients
KW - Food-cobalamin malabsorption
KW - Oral cobalamin therapy
N1 - Accession Number: 26487851; Andrès, Emmanuel 1; Email Address: emmanuel.andres@chru-strasbourg.fr Vidal-Alaball, Josep 2,3 Federici, Laure 1 Loukili, Noureddine Henoun 4 Zimmer, Jacques 5 Kaltenbach, Georges 6; Affiliation: 1: Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, France 2: National Public Health Service for Wales, UK 3: Department of General Practice, Cardiff University, UK 4: Department of Infection Control Management, Hôpital Calmette, CHRU de Lille, France 5: Laboratoire d'Immunogénétique-Allergologie, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg 6: Department of Internal Medicine and Geriatrics, Hôpitaux Universitaires de Strasbourg, France; Source Info: Oct2007, Vol. 18 Issue 6, p456; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: MEDICAL literature; Subject Term: MEDICAL research; Subject Term: INTERNET in medicine; Author-Supplied Keyword: Cobalamin; Author-Supplied Keyword: Cobalamin deficiency; Author-Supplied Keyword: Elderly patients; Author-Supplied Keyword: Food-cobalamin malabsorption; Author-Supplied Keyword: Oral cobalamin therapy; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ejim.2007.02.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Won, Se-Ra
AU - Kim, Seung-Kyum
AU - Kim, Yong-Mu
AU - Lee, Phil-Ho
AU - Ryu, Jae-Hyung
AU - Kim, Jang-Won
AU - Rhee, Hae-Ik
T1 - Licochalcone A: A lipase inhibitor from the roots of Glycyrrhiza uralensis
JO - Food Research International
JF - Food Research International
Y1 - 2007/10//
VL - 40
IS - 8
M3 - Article
SP - 1046
EP - 1050
SN - 09639969
AB - Abstract: In order to develop a functional food and anti-obesity drug through the inhibition of absorption of dietary lipids, we investigated the inhibitory effects on pancreatic lipase of extracts from more than 800 species of herbs in Korea. In this study, licochalcone A was isolated from the ethyl acetate/n-hexane fraction of ethyl acetate extract of the roots of Glycyrrhiza uralensis. Its structure was elucidated by 1H NMR, 13C NMR and HR-EI mass spectroscopy. Licochalcone A substantially inhibited activity with IC50 value of 35μg/mL (103.4μM). In an investigation of reversibility, licochalcone A was shown to be reversible to pancreatic lipase. The inhibition mode of licochalcone A was a non-competitive inhibitor, determined by Lineweaver–Burk plot analysis, and K i value was 11.2μg/mL (32.8μM). Furthermore, licochalcone A significantly reduced the production of oleic acid with not only artificial substrate DNPB but natural substrate triolein by pancreatic lipase. [Copyright &y& Elsevier]
AB - Copyright of Food Research International is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIPASES -- Inhibitors
KW - GLYCYRRHIZA
KW - OBESITY
KW - HERBS
KW - Glycyrrhiza uralensis
KW - Licochalcone A
KW - Lipase inhibitor
KW - Obesity
N1 - Accession Number: 26149703; Won, Se-Ra 1 Kim, Seung-Kyum 1 Kim, Yong-Mu 2 Lee, Phil-Ho 3 Ryu, Jae-Hyung 1 Kim, Jang-Won 1 Rhee, Hae-Ik 1,4; Email Address: rheehae@kangwon.ac.kr; Affiliation: 1: Division of Biotechnology, Kangwon National University, Chuncheon 200-701, South Korea 2: Busan Regional Food and Drug Administration, KFDA, Busan 608-829, South Korea 3: Department of Chemistry, Kangwon National University, Chuncheon 200-701, South Korea 4: Institute of Bioscience & Biotechnology, Kangwon National University, Chuncheon 200-701, South Korea; Source Info: Oct2007, Vol. 40 Issue 8, p1046; Subject Term: LIPASES -- Inhibitors; Subject Term: GLYCYRRHIZA; Subject Term: OBESITY; Subject Term: HERBS; Author-Supplied Keyword: Glycyrrhiza uralensis; Author-Supplied Keyword: Licochalcone A; Author-Supplied Keyword: Lipase inhibitor; Author-Supplied Keyword: Obesity; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodres.2007.05.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Richard B.
AU - Cheung, Robyn
AU - Owens, Pamela
AU - Wilson, R. Mark
AU - Simpson, Lisa
T1 - Medicaid Markets and Pediatric Patient Safety in Hospitals.
JO - Health Services Research
JF - Health Services Research
Y1 - 2007/10//
VL - 42
IS - 5
M3 - Article
SP - 1981
EP - 1998
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To examine the association of Medicaid market characteristics to potentially preventable adverse medical events for hospitalized children, controlling for patient- and hospital-level factors. Data Sources/Study Setting. Two carefully selected Agency for Healthcare Research and Quality (AHRQ) pediatric patient safety indicators (decubitus ulcers and laceration) are analyzed using the new pediatric-specific, risk-adjusting, patient safety algorithm from the AHRQ. All pediatric hospital discharges for patients age 0–17 in Florida, New York, and Wisconsin, and at risk of any of these two patient safety events, are examined for the years 1999–2001 ( N=859,922). Study Design. Logistic regression on the relevant pool of discharges estimates the probability an individual patient experiences one of the two PSI events. Data Extraction Methods. Pediatric discharges from the 1999 to 2001 State Inpatient Databases (SIDs) from the AHRQ Healthcare Cost and Utilization Project, merged with hospital-level data from the American Hospital Association's Annual Survey, Medicaid data obtained from the Centers for Medicare and Medicaid Services and state Medicaid offices, and private and Medicaid managed care enrollment data obtained from InterStudy, are used in the estimations. Principal Findings. At the market level, patients in markets in which Medicaid payers face relatively little competition are more likely to experience a patient safety event (odds ratio [OR]=1.602), while patients in markets in which hospitals face relatively little competition are less likely to experience an adverse event (OR=0.686). At the patient-discharge and hospital levels, Medicaid characteristics are not significantly associated with the incidence of a pediatric patient safety event. Conclusions. Our analysis offers additional insights to previous work and suggests a new factor—the Medicaid-payer market—as relevant to the issue of pediatric patient safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Hospital care
KW - PEDIATRICS
KW - CHILDREN'S hospitals
KW - HOSPITALS -- Safety measures
KW - MEDICAID
KW - UNITED States
KW - child health
KW - Medicaid
KW - patient safety
N1 - Accession Number: 26518043; Smith, Richard B. 1 Cheung, Robyn 2 Owens, Pamela 3 Wilson, R. Mark 4 Simpson, Lisa 5; Affiliation: 1: College of Business, University of South Florida St. Petersburg, 140 Seventh Avenue South, COB 348, St. Petersburg, FL 33701 2: Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing, Philadelphia, PA 3: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD 4: College of Business, University of South Florida St. Petersburg, St. Petersburg, FL 5: Division of Child Health Outcomes, Health Sciences Center, University of South Florida, St. Petersburg, FL; Source Info: Oct2007, Vol. 42 Issue 5, p1981; Subject Term: CHILDREN -- Hospital care; Subject Term: PEDIATRICS; Subject Term: CHILDREN'S hospitals; Subject Term: HOSPITALS -- Safety measures; Subject Term: MEDICAID; Subject Term: UNITED States; Author-Supplied Keyword: child health; Author-Supplied Keyword: Medicaid; Author-Supplied Keyword: patient safety; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; NAICS/Industry Codes: 622112 Paediatric hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 18p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2007.00698.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaida, Kosuke
AU - Åkerstedt, Torbjörn
AU - Kecklund, Göran
AU - Nilsson, Jens P.
AU - Axelsson, John
T1 - Use of Subjective and Physiological Indicators of Sleepiness to Predict Performance during a Vigilance Task.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 520
EP - 526
SN - 00198366
AB - The article presents a study which examines the predictability of subjective and physiological indicators of sleepiness during a vigilance task. Correlation analysis of the electrophysiological and performance data obtained from 13 healthy male volunteers reveals that sleepiness indicators and standard deviation of heart rate were significantly correlated with succeeding performance on the vigilance test.
KW - Health risk assessment
KW - Industrial hygiene
KW - Drowsiness
KW - Health status indicators
KW - Electrophysiology
KW - Heart beat
KW - EEG
KW - Heart rate variability
KW - Karolinska sleepiness scale
KW - Prediction
KW - Sleepiness
N1 - Accession Number: 32532111; Kaida, Kosuke 1,2,3; Åkerstedt, Torbjörn 2,3; Kecklund, Göran 2,3; Nilsson, Jens P. 3; Axelsson, John 2,3; Affiliations: 1: National Institute of Occupational Safety and Health, Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; 3: National Institute for Psychosocial Medicine (IPM), Stockholm, Sweden; Issue Info: 2007, Vol. 45 Issue 4, p520; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial hygiene; Subject Term: Drowsiness; Subject Term: Health status indicators; Subject Term: Electrophysiology; Subject Term: Heart beat; Author-Supplied Keyword: EEG; Author-Supplied Keyword: Heart rate variability; Author-Supplied Keyword: Karolinska sleepiness scale; Author-Supplied Keyword: Prediction; Author-Supplied Keyword: Sleepiness; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Iwakiri, Kazuyuki
AU - Sotoyama, Midori
AU - Mori, Ippei
AU - Saito, Susumu
T1 - Does Leaning Posture on the Kitchen Counter Alleviate Workload on the Low Back and Legs during Dishwashing?
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 535
EP - 545
SN - 00198366
AB - The article presents a study which evaluates the effects of leaning posture on the kitchen counter on subjective discomfort and muscle activity in the low back and legs. Observation of 12 female volunteers who were asked to wash plates for 30 minutes in three working postures suggests that the effects of leaning posture on the kitchen counter were not enough to decrease the workload on the low back and legs.
KW - Health risk assessment
KW - HEALTH
KW - Posture -- Physiological aspects
KW - Pain
KW - Lumbar pain
KW - Women
KW - Dishwashing
KW - Kitchen counter
KW - Low back pain
KW - Posture
KW - Standing aid
N1 - Accession Number: 32532113; Iwakiri, Kazuyuki 1; Sotoyama, Midori 1; Mori, Ippei 1; Saito, Susumu 2; Affiliations: 1: National Institute of Occupational Safety and Health, Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan; 2: Institute for Science of Labour, Sugao 2-8-14, Miyamae-ku, Kawasaki 216-8501, Japan; Issue Info: 2007, Vol. 45 Issue 4, p535; Thesaurus Term: Health risk assessment; Thesaurus Term: HEALTH; Subject Term: Posture -- Physiological aspects; Subject Term: Pain; Subject Term: Lumbar pain; Subject Term: Women; Author-Supplied Keyword: Dishwashing; Author-Supplied Keyword: Kitchen counter; Author-Supplied Keyword: Low back pain; Author-Supplied Keyword: Posture; Author-Supplied Keyword: Standing aid; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 1 Diagram, 5 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rui-Sheng Wang
AU - Ohtani, Katsumi
AU - Suda, Megumi
AU - Kitagawa, Kyoko
AU - Nakayama, Keiichi
AU - Kawamoto, Toshihiro
AU - Nakajima, Tamie
T1 - Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 574
EP - 578
SN - 00198366
AB - The article presents a study which investigates the effects of aldehyde dehydrogenase 2 (ALDH2) on the toxicity of ethylene glycol monoethyl ether (EGEE) by comparing an ALDH2 knockout mice with wild-type mice. Results of the analysis using a Hamilton-Thorne Sperm analyzer suggest that inactivation of the ALDH2 enzyme due to gene mutation may be linked to differences in the susceptibility to EGEE-induced sperm toxicity.
KW - Mutation (Biology)
KW - Aldehyde dehydrogenase
KW - Methoxyethanol
KW - Toxicological interactions
KW - Spermatozoa
KW - Reproductive toxicology
KW - ALDH2 knockout mouse
KW - Ethoxyacetic acid
KW - Ethylene glycol monoethyl ether
KW - Reproductive toxicity
N1 - Accession Number: 32532117; Rui-Sheng Wang 1; Ohtani, Katsumi 1; Suda, Megumi 1; Kitagawa, Kyoko 2; Nakayama, Keiichi 3; Kawamoto, Toshihiro 4; Nakajima, Tamie 5; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Biochemistry, Hamamatsu Medical University, Hamamatsu, Japan; 3: Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; 4: Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan; 5: Department of Occupational and Environmental Health, Nagoya University, Nagoya, Japan; Issue Info: 2007, Vol. 45 Issue 4, p574; Thesaurus Term: Mutation (Biology); Subject Term: Aldehyde dehydrogenase; Subject Term: Methoxyethanol; Subject Term: Toxicological interactions; Subject Term: Spermatozoa; Subject Term: Reproductive toxicology; Author-Supplied Keyword: ALDH2 knockout mouse; Author-Supplied Keyword: Ethoxyacetic acid; Author-Supplied Keyword: Ethylene glycol monoethyl ether; Author-Supplied Keyword: Reproductive toxicity; Number of Pages: 5p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Leggat, Peter A.
AU - Kedjarune, Ureporn
AU - Smith, Derek R.
T1 - Occupational Health Problems in Modern Dentistry: A Review.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 611
EP - 621
SN - 00198366
AB - The article presents a study which reviews the results of several research relating to occupational health problems in dental practice. Researchers observed that many occupational health problems still persist in modern dentistry, including percutaneous exposure incidents (PEI) and exposure to infectious diseases. These findings suggest the need for dentists to remain constantly informed regarding up-to-date measures on how to deal with newer technologies and dental materials.
KW - HEALTH
KW - Occupational diseases
KW - Occupational hazards
KW - Industrial hygiene
KW - Public health research
KW - Dentists
KW - Diseases -- Risk factors
KW - Dentistry
KW - Dermatitis
KW - Infectious diseases
KW - Musculoskeletal pain
N1 - Accession Number: 32532121; Leggat, Peter A. 1; Kedjarune, Ureporn 2; Smith, Derek R. 1,3; Affiliations: 1: Anton Breinl Centre for Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4811, Australia; 2: Department of Oral Biology and Occlusion, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand; 3: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; Issue Info: 2007, Vol. 45 Issue 4, p611; Thesaurus Term: HEALTH; Thesaurus Term: Occupational diseases; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial hygiene; Thesaurus Term: Public health research; Subject Term: Dentists; Subject Term: Diseases -- Risk factors; Author-Supplied Keyword: Dentistry; Author-Supplied Keyword: Dermatitis; Author-Supplied Keyword: Infectious diseases; Author-Supplied Keyword: Musculoskeletal pain; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Smith, Derek R.
T1 - Historical Development of the Journal Impact Factor and its Relevance for Occupational Health.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 730
EP - 742
SN - 00198366
AB - The article presents a study which provides a descriptive history of the journal impact factor and a discussion of its relevance on occupational health. Researchers have described the developmental milestones, inherent shortcomings and future challenges, along with the techniques used for increasing the impact factor and some potential strategies for the improvement of the citation indexing system.
KW - Industrial hygiene
KW - Industrial safety
KW - Science -- Periodicals -- Publishing
KW - Periodical publishing
KW - Scholarly periodicals
KW - Scientific community
KW - Citation indexes
KW - Citation Classics
KW - Citation Index
KW - Impact Factor
KW - Journal Publishing
KW - Occupational Health
N1 - Accession Number: 32532132; Smith, Derek R. 1; Affiliations: 1: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; Issue Info: 2007, Vol. 45 Issue 4, p730; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Subject Term: Science -- Periodicals -- Publishing; Subject Term: Periodical publishing; Subject Term: Scholarly periodicals; Subject Term: Scientific community; Subject Term: Citation indexes; Author-Supplied Keyword: Citation Classics; Author-Supplied Keyword: Citation Index; Author-Supplied Keyword: Impact Factor; Author-Supplied Keyword: Journal Publishing; Author-Supplied Keyword: Occupational Health; NAICS/Industry Codes: 511120 Periodical Publishers; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ojima, Jun
T1 - Efficiency of a Tool-mounted Local Exhaust Ventilation System for Controlling Dust Exposure during Metal Grinding Operations.
JO - Industrial Health
JF - Industrial Health
Y1 - 2007/10//
VL - 45
IS - 4
M3 - Article
SP - 817
EP - 819
SN - 00198366
AB - The article presents a study that describes the application of tool-mounted local exhaust ventilation (LEV) system attached to a hand-held disk grinder and evaluates its effectiveness at dust control. The respirable dust concentration around the grinding wheel during metal surface grinding with and without the use of the LEV is assessed to determine the system's effectiveness. It shows that the average respirable grinding dust concentration declined from 7.73 mg/m³ to 4.87 mg/m³.
KW - Exhaust systems
KW - Ventilation
KW - Dust control
KW - Wheels
KW - Grinding & polishing
KW - Dust exposure
KW - Metal grinding
N1 - Accession Number: 32532140; Ojima, Jun 1; Affiliations: 1: National Institute of Occupational Safety and Health, 21-1, Nagao 6 chome, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2007, Vol. 45 Issue 4, p817; Thesaurus Term: Exhaust systems; Thesaurus Term: Ventilation; Thesaurus Term: Dust control; Subject Term: Wheels; Subject Term: Grinding & polishing; Author-Supplied Keyword: Dust exposure; Author-Supplied Keyword: Metal grinding; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; Number of Pages: 3p; Illustrations: 1 Black and White Photograph, 2 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tornøe, Christoffer W.
AU - Tworzyanski, Jeffrey J.
AU - Imoisili, Menfo A.
AU - Alexander, John J.
AU - Korth-Bradley, Joan M.
AU - Gobburu, Jogarao V.S.
T1 - Optimising piperacillin/tazobactam dosing in paediatrics
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2007/10//
VL - 30
IS - 4
M3 - Article
SP - 320
EP - 324
SN - 09248579
AB - Abstract: Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this analysis is to describe the basis for the dosing recommendations in this age group. Pharmacokinetic (PK) parameters and demographic covariates from 53 children enrolled in two paediatric studies were used in the analysis. Individual drug clearance (CL) values calculated by non-compartmental methods were available. The influence of demographic covariates on CL was investigated by non-linear regression. The analysis identified CL to be dependent on body weight. CL was also found to be influenced by age in paediatric patients ≤2 years, which is consistent with the expectation based on maturation of renal function. The population PK analysis and simulations, utilising comparable adult exposures as a basis to explore optimal dosing, resulted in the following dosing recommendations: for paediatric patients ≥9 months, a dose of 100/12.5mg/kg every 8h showed exposures similar to adults; for paediatric patients aged 2–9 months, the dose of 100/12.5mg/kg should be reduced by a factor of 0.8 (i.e. 80/10mg/kg), likely due to immature renal function. Based upon this analysis, dosing recommendations for paediatric patients down to 2 months of age were incorporated in the labelling. No data were available to allow additional recommendations for paediatric patients <2 months of age to be made. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medicine
KW - Pediatrics
KW - Juvenile diseases
KW - Pharmacokinetics
KW - Anti-infectives
KW - Paediatric dosing
KW - Pharmacometric analysis
N1 - Accession Number: 26488065; Tornøe, Christoffer W. 1; Email Address: christoffer.tornoe@fda.hhs.gov; Tworzyanski, Jeffrey J. 1; Imoisili, Menfo A. 2; Alexander, John J. 2; Korth-Bradley, Joan M. 3; Gobburu, Jogarao V.S. 1; Affiliations: 1: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; 2: Office of New Drugs, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; 3: Early Development and Clinical Pharmacology, Wyeth Research, Collegeville, PA 19426, USA; Issue Info: Oct2007, Vol. 30 Issue 4, p320; Thesaurus Term: Medicine; Subject Term: Pediatrics; Subject Term: Juvenile diseases; Subject Term: Pharmacokinetics; Author-Supplied Keyword: Anti-infectives; Author-Supplied Keyword: Paediatric dosing; Author-Supplied Keyword: Pharmacometric analysis; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2007.05.014
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wu, Huiquan
AU - Heilweil, Edwin J.
AU - Hussain, Ajaz S.
AU - Khan, Mansoor A.
T1 - Process analytical technology (PAT): Effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2007/10//
VL - 343
IS - 1/2
M3 - Article
SP - 148
EP - 158
SN - 03785173
AB - Abstract: The aim of this study was to use terahertz spectroscopy to characterize pharmaceutical materials and tablets, and to understand the effects of measuring conditions and compositional variability on the data quality. Tests were performed on five formulation components (theophylline, lactose, starch, Avicel, magnesium stearate) and a series of tablets composed of various concentrations of theophylline and excipients. Transmission spectra of polyethylene (PE) disks derived from each of the samples were analyzed. Three factors (component loading, component chemistry, and disk drying time) were screened as critical factors associated with the magnitude and location of THz absorbance peaks. Applying the standard sample spectra divided by PE reference spectra ratio method revealed that, to a large extent, PE was responsible for the disk drying time dependence. Direct spectral feature analysis along with mass-transfer analysis of the disk drying process revealed THz absorption peak maxima of lactose (255cm−1) and water (54 and 210cm−1) which is also supported by literature values for the peak maxima assignment for water. Particle scattering due to specimen and PE was found to be also partially responsible for the observed spectral intensities. The importance of THz spectroscopy was demonstrated for characterization of pharmaceutical materials and tablet. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLXANTHINES
KW - THEOPHYLLINE
KW - BRONCHODILATOR agents
KW - STABILIZING agents
KW - Amorphous state
KW - Characterization
KW - Crystalline materials
KW - Mass-transfer analysis
KW - Measurement process
KW - Process analytical technology (PAT)
KW - Terahertz spectroscopy
N1 - Accession Number: 26412951; Wu, Huiquan 1; Email Address: huiquan.wu@fda.hhs.gov Heilweil, Edwin J. 2 Hussain, Ajaz S. 3 Khan, Mansoor A. 1; Affiliation: 1: Division of Product Quality Research (DPQR, HFD-940), Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, MD 20993, USA 2: Optical Technology Division, Physics Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8443, USA 3: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, USA; Source Info: Oct2007, Vol. 343 Issue 1/2, p148; Subject Term: METHYLXANTHINES; Subject Term: THEOPHYLLINE; Subject Term: BRONCHODILATOR agents; Subject Term: STABILIZING agents; Author-Supplied Keyword: Amorphous state; Author-Supplied Keyword: Characterization; Author-Supplied Keyword: Crystalline materials; Author-Supplied Keyword: Mass-transfer analysis; Author-Supplied Keyword: Measurement process; Author-Supplied Keyword: Process analytical technology (PAT); Author-Supplied Keyword: Terahertz spectroscopy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ijpharm.2007.05.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105761008
T1 - Genetic disorders: implications for allied health professionals: two case studies.
AU - Smith M
AU - Danoff JV
AU - Jain M
AU - Long TM
Y1 - 2007/10//2007 Oct
N1 - Accession Number: 105761008. Language: English. Entry Date: 20080711. Revision Date: 20150818. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA.
KW - Hereditary Diseases -- Diagnosis
KW - Abnormalities -- Diagnosis
KW - Chromosome Disorders -- Diagnosis
KW - Chromosome Mapping -- Methods
KW - Connective Tissue Diseases -- Diagnosis
KW - Ethics
KW - Genes
KW - Genetic Screening -- Methods
KW - Hereditary Diseases -- Classification
KW - Huntington's Disease -- Diagnosis
KW - Mitochondrial Myopathies -- Diagnosis
KW - Outcomes (Health Care)
KW - Physical Therapy -- Methods
SP - 14p
EP - 14p
JO - Internet Journal of Allied Health Sciences & Practice
JF - Internet Journal of Allied Health Sciences & Practice
JA - INTERNET J ALLIED HEALTH SCI PRACT
VL - 5
IS - 4
CY - Fort Lauderdale, Florida
PB - Nova Southeastern University, College of Allied Health
AB - With advances in study of the human genome, increasingly accurate genetic testing has become available. Genetic-based birth defects may result in progressive dysfunction. Consequently, because of the negative associations, many people do not want to consider prognostication testing or accept the most appropriate treatments. The allied health practitioner may see this as counter to the goal of optimal health care. However, consideration must be given to the patient's comfort with advanced knowledge. In this paper we discuss ethical, legal, and social implications of genetic testing and how these relate to patients seen in an allied health environment. First, background on genetic disorders, their causes, and how they are characterized is presented. Then two case studies are described. One is a 50-year female with Huntington's disease (chorea), an inherited autosomal dominant condition leading to central nervous system deterioration. The second is a 5-year boy with Stickler syndrome, a hereditary autosomal dominant connective tissue disorder affecting Type II collagen. Symptoms, therapeutic approaches, and long term prognoses are discussed. Working with patients having genetic disorders presents unique challenges for allied health professionals because of the social and political implications of these maladies. Suggestions are provided on how allied health professionals may respond to these issues.
SN - 1540-580X
AD - CDR, United States Public Health Service, Education Coordinator, National Institutes of Health, Department of Rehabilitation Medicine, Physical Therapy Section
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shixing Tang
AU - Jiangqin Zhao
AU - Storhoff, James J.
AU - Philip J. Norris
AU - Little, Richard F.
AU - Yarchoan, Robert
AU - Stramer, Susan L.
AU - Patno, Tim
AU - Domanus, Marc
AU - Dhar, Arindam
AU - Mirkin, Chad A.
AU - Hewlett, Indira K.
T1 - Nanoparticle-Based Biobarcode Amplification Assay (BCA) for Sensitive and Early Detection of Human Immunodeficiency Type 1 Capsid (p24) Antigen.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2007/10//10/1/2007
VL - 46
IS - 2
M3 - Article
SP - 231
EP - 237
SN - 15254135
AB - The article details the modification of a nanoparticle-based biobarcode amplification assay for early and sensitive detection of HIV-1 capsid antigen. It discusses the use of antip24 antibody-coated microplates to capture viral antigen and streptavidin-coated nanoparticle-based biobarcode DNAs for signal amplification.
KW - NANOPARTICLES
KW - HIV infections
KW - ANTIGENS
KW - HIV (Viruses)
KW - STREPTAVIDIN
KW - biobarcode
KW - detection
KW - HIV-1
KW - nanoparticle
KW - p24 antigen
N1 - Accession Number: 27021631; Shixing Tang 1; Email Address: shixing.tang@fda.hhs.gov Jiangqin Zhao 1 Storhoff, James J. 2 Philip J. Norris 3 Little, Richard F. 4 Yarchoan, Robert 4 Stramer, Susan L. 5 Patno, Tim 2 Domanus, Marc 1 Dhar, Arindam 1,6 Mirkin, Chad A. 7 Hewlett, Indira K. 1; Email Address: indira.hewlett@fda.hhs.gov; Affiliation: 1: Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 2: Nanosphere, Northbrook, IL 3: BIood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, CA 4: HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 5: American Red Cross, Biomedical Services Scientific Support Office, Gaithersburg, MD 6: National Cancer Institute-FDA Interagency Oncology Task Force, Bethesda, MD 7: Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, IL; Source Info: 10/1/2007, Vol. 46 Issue 2, p231; Subject Term: NANOPARTICLES; Subject Term: HIV infections; Subject Term: ANTIGENS; Subject Term: HIV (Viruses); Subject Term: STREPTAVIDIN; Author-Supplied Keyword: biobarcode; Author-Supplied Keyword: detection; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: nanoparticle; Author-Supplied Keyword: p24 antigen; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105918311
T1 - Treatment of adult HIV infection: antiretroviral update and overview [corrected] [published erratum appears in J NURSE PRACT 2007 Nov-Dec;3(10):728].
AU - Orsega S
Y1 - 2007/10//
N1 - Accession Number: 105918311. Language: English. Entry Date: 20080104. Revision Date: 20150818. Publication Type: Journal Article; pictorial; practice guidelines; review; tables/charts. Journal Subset: Blind Peer Reviewed; Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Advanced Nursing Practice. NLM UID: 101264817.
KW - Antiviral Agents -- Administration and Dosage
KW - Drug Toxicity
KW - HIV Infections -- Drug Therapy
KW - Acidosis, Lactic
KW - Advanced Nursing Practice
KW - Antiretroviral Therapy, Highly Active
KW - Antiviral Agents -- Adverse Effects
KW - Antiviral Agents -- Classification
KW - Antiviral Agents -- Pharmacodynamics
KW - Antiviral Agents -- Pharmacokinetics
KW - Diarrhea
KW - Drug Hypersensitivity
KW - Exanthema
KW - Female
KW - Genotype -- Evaluation
KW - Goals and Objectives
KW - Hepatitis B
KW - Hepatitis C
KW - Hepatotoxicity
KW - HIV Infections -- Physiopathology
KW - Lactation
KW - Medication Compliance
KW - Nausea and Vomiting
KW - Pancreas -- Drug Effects
KW - Pregnancy
KW - Protease Inhibitors
KW - United States Department of Health and Human Services
SP - 612
EP - 624
JO - Journal for Nurse Practitioners
JF - Journal for Nurse Practitioners
JA - J NURSE PRACT
VL - 3
IS - 9
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Up-to-date guidelines for nurse practitioners are critically important to keep up with the continuous advances in HIV treatment. With a key understanding of viral replication, combination therapy, treatment failure, and drug toxicities, the provider is able to have these reference tools to assist in monitoring the infection. Research development continues with a focus on new classes to inhibit different parts of the HIV cycle and drug class resistance and to determine the first- and second-line antiretroviral therapy. The purpose of this article is to provide an overview of the highly active antiretroviral therapy, basic understanding of when to initiate therapy, how to manage patients receiving these medications, treatment regimens, and useful guidelines.
SN - 1555-4155
AD - Officer in the US Public Health Service, Bethesda, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cook, Janine D.
AU - Strauss, Kathy A.
AU - Caplan, Yale H.
AU - LoDico, Charles P.
AU - Bush, Donna M.
T1 - Urine pH: the Effects of Time and Temperature after Collection.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 2007/10//
VL - 31
IS - 8
M3 - Article
SP - 486
EP - 496
SN - 01464760
AB - The article reports on the provisions of several drug testing program as imposed in the United States specially concerning the testing of urine samples. The author specifically cites the Mandatory Guidelines for Federal Workplace Drug Testing Programs with emphasis on its criteria for urine test. The criteria include specimen validity testing which includes urine pH cut-offs to determine whether or not a specific urine sample is adulterated or not. Moreover, the author cites the provisions of Public Law 100-71 which enjoins the United States Department of Health and Human Services to publish mandatory guidelines which will provide the standard for drug testing and the necessary laboratory procedures attendant thereto.
KW - URINALYSIS
KW - CLINICAL chemistry
KW - ALLOXURIC substances
KW - BODY fluids
KW - EXCRETION
KW - KIDNEYS
KW - CYNURENIC acid
KW - DRUG use testing
KW - MEDICAL screening
KW - EMPLOYEE rules
N1 - Accession Number: 27164441; Cook, Janine D. 1 Strauss, Kathy A. 2 Caplan, Yale H. 3 LoDico, Charles P. 4 Bush, Donna M. 4; Email Address: donna.bush@samhsa.hhs.gov; Affiliation: 1: Department of Pathology, Mercy Medical Center, Baltimore, Maryland 2: School of Medicine, Department of Epidemiology, University of Maryland Baltimore, Baltimore, Maryland 3: National Scientific Services, Baltimore, Maryland 4: Division of Workplace Programs, Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, One Choke Cherry Road, Rockville, Maryland; Source Info: Oct2007, Vol. 31 Issue 8, p486; Subject Term: URINALYSIS; Subject Term: CLINICAL chemistry; Subject Term: ALLOXURIC substances; Subject Term: BODY fluids; Subject Term: EXCRETION; Subject Term: KIDNEYS; Subject Term: CYNURENIC acid; Subject Term: DRUG use testing; Subject Term: MEDICAL screening; Subject Term: EMPLOYEE rules; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 11p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, G.S.
AU - Betty, R.G.
AU - Brockmann, J. E.
AU - Lucero, D. A.
AU - Souza, C. A.
AU - Walsh, K. S.
AU - Boucher, R. M.
AU - Tezak, M. S.
AU - Wilson, M. C.
AU - Rudolph, T.
AU - Lindquist, H.D.A.
AU - Martinez, K.F.
T1 - Evaluation of rayon swab surface sample collection method for Bacillus spores from nonporous surfaces.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2007/10//
VL - 103
IS - 4
M3 - Article
SP - 1074
EP - 1080
PB - Wiley-Blackwell
SN - 13645072
AB - Aim: To evaluate US Centers for Disease Control and Prevention recommended swab surface sample collection method for recovery efficiency and limit of detection for powdered Bacillus spores from nonporous surfaces. Methods and Results: Stainless steel and painted wallboard surface coupons were seeded with dry aerosolized Bacillus atrophaeus spores and surface concentrations determined. The observed mean rayon swab recovery efficiency from stainless steel was 0·41 with a standard deviation (SD) of ±0·17 and for painted wallboard was 0·41 with an SD of ±0·23. Evaluation of a sonication extraction method for the rayon swabs produced a mean extraction efficiency of 0·76 with an SD of ±0·12. Swab recovery quantitative limits of detection were estimated at 25 colony forming units (CFU) per sample area for both stainless steel and painted wallboard. Conclusions: The swab sample collection method may be appropriate for small area sampling (10 –25 cm2) with a high agent concentration, but has limited value for large surface areas with a low agent concentration. The results of this study provide information necessary for the interpretation of swab environmental sample collection data, that is, positive swab samples are indicative of high surface concentrations and may imply a potential for exposure, whereas negative swab samples do not assure that organisms are absent from the surfaces sampled and may not assure the absence of the potential for exposure. Significance and Impact of the Study: It is critical from a public health perspective that the information obtained is accurate and reproducible. The consequence of an inappropriate public health response founded on information gathered using an ineffective or unreliable sample collection method has the potential for undesired social and economic impact. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Rayon
KW - Bacterial spores
KW - Extraction (Chemistry)
KW - Public health
KW - Bacillus anthracis -- Decontamination
KW - Swabs (Surgery)
KW - Standard deviations
KW - Sonication
KW - Synthetic textiles
KW - sample recovery efficiency
KW - spore sampling
KW - surface sampling
N1 - Accession Number: 26771004; Brown, G.S. 1; Email Address: gbrown@sandia.gov; Betty, R.G. 1; Brockmann, J. E. 1; Lucero, D. A. 1; Souza, C. A. 1; Walsh, K. S. 1; Boucher, R. M. 2; Tezak, M. S. 3; Wilson, M. C. 3; Rudolph, T. 4; Lindquist, H.D.A. 5; Martinez, K.F. 6; Affiliations: 1: Sandia National Laboratories, Albuquerque, NM, USA; 2: Orion International Technologies, Albuquerque, NM, USA; 3: American Staff Augmentation Providers, Albuquerque, NM, USA; 4: Tactical Staffing Resources, Albuquerque, NM, USA; 5: United States Environmental Protection Agency Homeland Security Research Center, Cincinnati, OH, USA; 6: National Institute of Occupational Safety and Health, Cincinnati, OH, USA; Issue Info: Oct2007, Vol. 103 Issue 4, p1074; Thesaurus Term: Rayon; Thesaurus Term: Bacterial spores; Thesaurus Term: Extraction (Chemistry); Thesaurus Term: Public health; Thesaurus Term: Bacillus anthracis -- Decontamination; Subject Term: Swabs (Surgery); Subject Term: Standard deviations; Subject Term: Sonication; Subject Term: Synthetic textiles; Author-Supplied Keyword: sample recovery efficiency; Author-Supplied Keyword: spore sampling; Author-Supplied Keyword: surface sampling; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325220 Artificial and Synthetic Fibers and Filaments Manufacturing; NAICS/Industry Codes: 313110 Fiber, Yarn, and Thread Mills; NAICS/Industry Codes: 313230 Nonwoven Fabric Mills; Number of Pages: 7p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1365-2672.2007.03331.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Dung-Tsa Chen
AU - Chen, James J.
AU - Cheng, Gary
AU - Sue-Hwa Lin
AU - Seng-Jaw Soong
T1 - A Two-Stage Binomial Test Approach of Gene Identification in Oligonucleotide Arrays.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/10//
VL - 17
IS - 5
M3 - Article
SP - 903
EP - 918
PB - Taylor & Francis Ltd
SN - 10543406
AB - Most statistical approaches summarize the probe-level expression data into gene-level measures, which then are used for downstream statistical analyses. However, there are some limitations in using the gene level data for analysis, such as nonhomogeneous probe effects and the interaction effect (e.g., alternative splicing). In this paper, we consider a two-stage binomial test with a weighted probe rank approach to determine differentially expressed genes. Using a series of benchmark gene array datasets, we show the two-stage binomial test approach yielded a higher positive predictivity and a higher sensitivity than the conventional RMA, GCRMA, Dchip, and ANOVA approaches. In data application, the two-stage binomial test identified a subset of genes strongly related to cell proliferation in the prolactin study, and a subset of genes associated with lymph node metastasis in the breast cancer dataset. In addition, by exploring the proportion of probes with expression changes and the probe expression plot, the two-stage binomial test helped detect an alternative splicing form of the prolactin gene in the prolactin study. In the breast cancer dataset, the approach also identified one potential alternative splicing gene. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - BINOMIAL theorem
KW - OLIGONUCLEOTIDES
KW - STATISTICS
KW - GENES
KW - PROLACTIN
KW - Gene selection
KW - Positive predictivity
KW - Sensitivity
KW - Two-stage binomial test
KW - Weighted probe rank
N1 - Accession Number: 26655760; Dung-Tsa Chen 1; Email Address: Dung-Tsa.Chen@moffitt.org Chen, James J. 2 Cheng, Gary 3 Sue-Hwa Lin 4 Seng-Jaw Soong 5; Affiliation: 1: Biostatistics Division, Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA and Biostatistics Center, China Medical University, Taichung, Taiwan 3: Department of Mechanical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA 4: Department of Molecular Pathology, University of Texas, Houston, Texas, USA 5: Biostatistics and Bioinformatics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA; Source Info: Oct2007, Vol. 17 Issue 5, p903; Subject Term: GENE expression; Subject Term: BINOMIAL theorem; Subject Term: OLIGONUCLEOTIDES; Subject Term: STATISTICS; Subject Term: GENES; Subject Term: PROLACTIN; Author-Supplied Keyword: Gene selection; Author-Supplied Keyword: Positive predictivity; Author-Supplied Keyword: Sensitivity; Author-Supplied Keyword: Two-stage binomial test; Author-Supplied Keyword: Weighted probe rank; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 16p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/10543400701514064
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Samuel P. Tucker
T1 - Investigation of reagent distributions on glass fiber membrane filters used in air sampling.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2007/10//
VL - 9
IS - 10
M3 - Article
SP - 1122
EP - 1130
SN - 14640325
AB - This project has arisen from the need to produce GFFs (glass fiber filters) bearing a thin and evenly distributed coating of a selected reagent in the equatorial plane for breakthrough studies. However, it has been discovered that today’s two general techniques for coating GFFs (total immersion and application of reagent solution to GFFs) have usually produced unevenly distributed coatings of reagent in the equatorial plane. In addition, quantities of reagent on GFFs from commercial sources may vary widely in the same lot of coated GFFs. Consequences are variability in capacity of coated filters at the point of breakthrough and, perhaps, wasted reagent. Although today’s reagent-coated filters may be satisfactory for routine air sampling, such filters may be unacceptable for precise breakthrough studies. Research has been conducted successfully to produce nearly evenly distributed coatings of reagents in the equatorial plane of GFFs by application of reagent solutions to the centers of GFFs which are resting on crisscrossing, fine, stainless-steel wire. Distributions of coatings have been determined by punching out twenty-one 5-mm circles from each GFF and analyzing each circle by flow-injection with a UV detector. Lowest achievable relative standard deviations of measurement (RSDs) for reagents in 5-mm circles have been 5 to 7%. Reagents studied have included 1-(2-pyridyl)piperazine (1-2PP), 2,4-dinitrophenylhydrazine (DNPH), and 1-(9-anthracenylmethyl)piperazine (MAP). Factors affecting the distribution of such coatings include choice of reagent and choice of solvent for the reagent solution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Filters & filtration
KW - Chemical tests & reagents
KW - Glass fibers
KW - Membranes (Technology)
N1 - Accession Number: 27022782; Samuel P. Tucker 1; Affiliations: 1: National Institute for Occupational Safety and Health Cincinnati USA spt1@cdc.gov; Issue Info: Oct2007, Vol. 9 Issue 10, p1122; Thesaurus Term: Filters & filtration; Thesaurus Term: Chemical tests & reagents; Subject Term: Glass fibers; Subject Term: Membranes (Technology); NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 326193 Motor vehicle plastic parts manufacturing; NAICS/Industry Codes: 327993 Mineral Wool Manufacturing; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 327212 Other Pressed and Blown Glass and Glassware Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, James J.
AU - Chen, Yi-Ju
AU - Cheng, Kuang Fu
T1 - Statistics for Risk Assessment of Chemical Carcinogens.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2007/10//Oct-Dec2007
VL - 25
IS - 4
M3 - Article
SP - 281
EP - 312
SN - 10590501
AB - Risk assessment is a scientific process of evaluation of potential health risks of chemical exposures to humans from available information. It involves analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level. Because of lack of human exposure data, the major source of information for studying potential health effects of chemicals on humans is generally obtained from animal dose response experiments. Animal data are often evaluated in two aspects via statistical analysis: qualitative testing and quantitative estimation. The qualitative testing is to determine if the chemical causes an adverse health effect, i.e., if there is a statistically significant difference between treated and control animals. Quantitative estimation involves fitting a dose-response model to derive an allowable exposure level for humans. This paper reviews statistical principles and procedures for qualitative and quantitative approaches to human risk assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - CHEMICALS
KW - STATISTICS
KW - CARCINOGENS -- Dose-response relationship
KW - THRESHOLD limit values (Industrial toxicology)
KW - ANIMAL experimentation
KW - BIOLOGICAL assay
KW - PROBABILISTIC number theory
KW - Benchmark Dose
KW - Carcinogenicity Bioassay
KW - Chemical Mixture
KW - Cumulative Risk
KW - Hierarchical Model
KW - Point of Departure
KW - Probabilistic Risk Assessment
KW - Reference Dose
N1 - Accession Number: 27529706; Chen, James J. 1 Chen, Yi-Ju 2 Cheng, Kuang Fu 3; Affiliation: 1: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, Arkansas, USA,Biostatistics Center, School of Public Health, China Medical University, Taichung, Taiwan 2: Department of Mathematics, National Chung Cheng University, Chia-Yi, Taiwan 3: Biostatistics Center, School of Public Health, China Medical University, Taichung, Taiwan; Source Info: Oct-Dec2007, Vol. 25 Issue 4, p281; Subject Term: HEALTH risk assessment; Subject Term: CHEMICALS; Subject Term: STATISTICS; Subject Term: CARCINOGENS -- Dose-response relationship; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: ANIMAL experimentation; Subject Term: BIOLOGICAL assay; Subject Term: PROBABILISTIC number theory; Author-Supplied Keyword: Benchmark Dose; Author-Supplied Keyword: Carcinogenicity Bioassay; Author-Supplied Keyword: Chemical Mixture; Author-Supplied Keyword: Cumulative Risk; Author-Supplied Keyword: Hierarchical Model; Author-Supplied Keyword: Point of Departure; Author-Supplied Keyword: Probabilistic Risk Assessment; Author-Supplied Keyword: Reference Dose; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 32p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/10590500701703989
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brzezinski, Jennifer L.
AU - Craft, David L.
T1 - Evaluation of an In Vitro Bioassay for the Detection of Purified Ricin and Castor Bean in Beverages and Liquid Food Matrices.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/10//
VL - 70
IS - 10
M3 - Article
SP - 2377
EP - 2382
SN - 0362028X
AB - The potential use of ricin as a biological weapon in food highlights the necessity for the development of food-specific detection methods. Current methods for the detection of ricin consist of various immunoassays, which detect only one subunit of the ricin toxin and therefore may not be indicative of a biologically active molecule. An in vivo assay, such as a mouse bioassay, can indicate the biological activity of the toxin; however, this method is not feasible for laboratories that do not have animal testing facilities. The purpose of this study was to develop an in vitro assay for the detection of biologically active ricin in beverages and liquid foods. Acidic and high-protein beverages were spiked with either purified ricin or ground castor beans and added to cultured human Jurkat cells. After an overnight incubation, the supernatant was tested for lactate dehydrogenase (LDH) activity with a colorimetric assay. LDH was released from the cytosol upon cell damage and was positively correlated with cell death. Ricin was detectable in all the matrices tested, with a sensitivity of 10 to 100 pg/ml. Biologically active ricin was detectable in all the matrices incubated with ground castor bean material. This method provides a confirmatory way to detect biologically active ricin that can be utilized by laboratories lacking animal facilities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ricin
KW - Plant toxins
KW - Lactate dehydrogenase
KW - Toxalbumins
KW - Castor beans
N1 - Accession Number: 27055424; Brzezinski, Jennifer L. 1; Email Address: jennifer.brzezinski@fda.hhs.gov; Craft, David L. 1; Affiliations: 1: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, Ohio 45237, USA; Issue Info: Oct2007, Vol. 70 Issue 10, p2377; Thesaurus Term: Ricin; Thesaurus Term: Plant toxins; Subject Term: Lactate dehydrogenase; Subject Term: Toxalbumins; Subject Term: Castor beans; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27055424&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Myers, L. P.
AU - Law, B. F.
AU - Fedorowicz, A.
AU - Siegel, P. D.
AU - Butterworth, L. F.
AU - Anderson, S. E.
AU - Sussman, G.
AU - Shapiro, M.
AU - Meade, B. J.
AU - Beezhold, D.
T1 - Identification of Phenolic Dermal Sensitizers in a Wound Closure Tape.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2007/10//
VL - 4
IS - 4
M3 - Article
SP - 303
EP - 310
PB - Taylor & Francis Ltd
SN - 1547691X
AB - A latex-allergic patient presented with a severe local reaction to a non-latex wound closure bandage following surgery. Extracts of the bandage were analyzed by gas chromatograph-electron impact-mass spectrometry (GC EI-MS) in the total ion monitoring mode. Components were identified by their ion mass fingerprint and elution time as a corresponding standard from the GC column. The chemicals identified were 4,4'-thiobis-(6-tert-butyl-m-cresol) (TBBC), 6-tert-Butyl-m-cresol (BC), 2,4-di-tert-butylphenol (BP) and erucamide (EA). Sensitization potential of these chemicals was evaluated using two quantitative structure-activity relationship (QSAR) programs. The phenol 2,6-di-tert-butyl-4-(hydroxymethyl)phenol (BHP) was also included in the test series. It was initially thought to be present in the bandage but detectable levels could not be confirmed. The potential for TBBC to induce a sensitization response was predicted by both Derek for Windows and TOPKAT 6.2. The potential for BC and BP to induce a sensitization response was predicted by Derek for Windows, but not TOPKAT. BHP and EA were not predicted to be sensitizers by either QSAR program. Local lymph node assay (LLNA) analysis of the chemicals identified TBBC, BP, and BC as potential sensitizers with EC3 values between 0.2 and 4.5%. None of the animals exhibited body weight loss or skin irritation at the concentrations tested. In agreement with the toxicological modeling, BHP did not induce a sensitization response in the LLNA. Following a positive LLNA response, TBBC, BP, and BC were further characterized by phenotypic analysis of the draining lymph nodes. A positive LLNA result coupled with a lack of increase in B220+IgE+ cell and serum IgE characterize these chemicals as Type IV sensitizers. These studies used a multidisciplinary approach combining clinical observation, GC-EI-MS for chemical identification, QSAR modeling of chemicals prior to animal testing, and the LLNA for determination of the sensitization potential of chemicals in a manufactured product. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Phenols
KW - Wounds & injuries
KW - Toxicology
KW - Latex
KW - Surgery
KW - dermal sensitizers
KW - hypersensitivity
KW - wound closures
N1 - Accession Number: 27688698; Myers, L. P. 1; Law, B. F. 1; Fedorowicz, A. 1; Siegel, P. D. 1; Butterworth, L. F. 1; Anderson, S. E. 1; Email Address: sanderson4@cdc.gov; Sussman, G. 2; Shapiro, M. 3; Meade, B. J. 1; Beezhold, D. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Department of Medicine, University of Toronto, Toronto, Ontario, Canada; 3: University of Toronto, Toronto, Ontario, Canada; Issue Info: Oct2007, Vol. 4 Issue 4, p303; Thesaurus Term: Allergy; Thesaurus Term: Phenols; Thesaurus Term: Wounds & injuries; Thesaurus Term: Toxicology; Subject Term: Latex; Subject Term: Surgery; Author-Supplied Keyword: dermal sensitizers; Author-Supplied Keyword: hypersensitivity; Author-Supplied Keyword: wound closures; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15476910701680236
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yong He
AU - Manischewitz, Jody
AU - Meseda, Clement A.
AU - Merchlinsky, Michael
AU - Vassell, Russell A.
AU - Sirota, Lev
AU - Berkower, Ira
AU - Golding, Hana
AU - Weiss, Carol D.
T1 - Antibodies to the A27 Protein of Vaccinia Virus Neutralize and Protect against Infection but Represent a Minor Component of Dryvax Vaccine—Induced Immunity.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/10//10/1/2007
VL - 196
IS - 7
M3 - Article
SP - 1026
EP - 1032
SN - 00221899
AB - The smallpox vaccine Dryvax, which consists of replication-competent vaccinia virus, elicits antibodies that play a major role in protection. Several vaccinia proteins generate neutralizing antibodies, but their importance for protection is unknown. We investigated the potency of antibodies to the A27 protein of the mature virion in neutralization and protection experiments and the contributions of A27 antibodies to Dryvax-induced immunity. Using a recombinant A27 protein (rA27), we confirmed that A27 contains neutralizing determinants and that vaccinia immune globulin (VIG) derived from Dryvax recipients contains reactivity to A27. However, VIG neutralization was not significantly reduced when A27 antibodies were removed, and antibodies elicited by an rA27 enhanced the protection conferred by VIG in passive transfer experiments. These findings demonstrate that A27 antibodies do not represent the major fraction of neutralizing activity in VIG and suggest that immunity may be augmented by vaccines and immune globulins that include strong antibody responses to A27. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SMALLPOX vaccine
KW - IMMUNOGLOBULINS
KW - SMALLPOX -- Prevention
KW - VACCINATION
KW - GLOBULINS
KW - VACCINIA
KW - GENETIC polymorphisms
KW - PREVENTIVE medicine
KW - THERAPEUTICS
N1 - Accession Number: 27150428; Yong He 1 Manischewitz, Jody 1 Meseda, Clement A. 1 Merchlinsky, Michael 1 Vassell, Russell A. 1 Sirota, Lev 2 Berkower, Ira 1 Golding, Hana 1 Weiss, Carol D. 1; Email Address: carol.weiss@fdahhs.gov; Affiliation: 1: Divisions of Viral Products 2: Biostatistics, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland; Source Info: 10/1/2007, Vol. 196 Issue 7, p1026; Subject Term: SMALLPOX vaccine; Subject Term: IMMUNOGLOBULINS; Subject Term: SMALLPOX -- Prevention; Subject Term: VACCINATION; Subject Term: GLOBULINS; Subject Term: VACCINIA; Subject Term: GENETIC polymorphisms; Subject Term: PREVENTIVE medicine; Subject Term: THERAPEUTICS; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1086/520936
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27150428&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106192350
T1 - Improving the complex nature of care transitions.
AU - Hughes RG
AU - Clancy CM
Y1 - 2007/10//Oct-Dec2007
N1 - Accession Number: 106192350. Language: English. Entry Date: 20071116. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 9200672.
KW - Patient Safety
KW - Transfer, Discharge
KW - Communication
KW - Health Informatics
KW - Quality of Health Care
KW - Research
SP - 289
EP - 292
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 22
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 17873723.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106192350&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mei-Lin Wang
AU - Zhi-En Wu
AU - Qin-Guo Du
AU - Kai-Liang Peng
AU - Ya-Dong Li
AU - Shao-Kui Li
AU - Gui-Hai Han
AU - Petsonk, Edward L.
T1 - Rapid Decline in Forced Expiratory Volume in 1 Second (FEV1) and the Development of Bronchitic Symptoms Among New Chinese Coal Miners.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/10//
VL - 49
IS - 10
M3 - Article
SP - 1143
EP - 1148
SN - 10762752
AB - The article discusses the study about rapid decline in Forced Expiratory Volume in 1 Second (FEV1) and the development of bronchitic symptoms among new Chinese coal miners. The study has aimed to investigate the relationship between the development of bronchitic symptoms and the early rapid decline of FEV1. It has used a two-stage and a mixed model approach to analyze data from 260 newly hired Chinese coal miners who completed approximately 5 to 16 health surveys during 3 years. The study has showed that among new coal miners, a sharp early decline in FEV1 is associated with the development of bronchitic symptoms.
KW - HEALTH surveys
KW - COAL miners
KW - BRONCHITIS
KW - OBSTRUCTIVE lung diseases
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - OCCUPATIONAL diseases
KW - ENVIRONMENTAL health
KW - CHINA
N1 - Accession Number: 27139056; Mei-Lin Wang 1 Zhi-En Wu 2 Qin-Guo Du 3 Kai-Liang Peng 2 Ya-Dong Li 3 Shao-Kui Li 3 Gui-Hai Han 3 Petsonk, Edward L. 1; Email Address: elp2@cdc.gov; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China 3: and Xuzhou Mining Group Company Ltd., Xuzhou, Jiangsu, People's Republic of China; Source Info: Oct2007, Vol. 49 Issue 10, p1143; Subject Term: HEALTH surveys; Subject Term: COAL miners; Subject Term: BRONCHITIS; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL safety; Subject Term: OCCUPATIONAL diseases; Subject Term: ENVIRONMENTAL health; Subject Term: CHINA; Number of Pages: 6p; Document Type: Article
L3 - 10.1097/JOM.0b013e31814b8d51
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27139056&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105845574
T1 - Rapid decline in forced expiratory volume in 1 second (FEV) and development of bronchitic symptoms among new Chinese coal miners.
AU - Wang M
AU - Wu Z
AU - Du Q
AU - Peng K
AU - Li Y
AU - Li S
AU - Han G
AU - Petsonk EL
Y1 - 2007/10//
N1 - Accession Number: 105845574. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Institute for Occupational Safety and Health. NLM UID: 9504688.
KW - Bronchiolitis -- Epidemiology
KW - Bronchiolitis -- Physiopathology
KW - Forced Expiratory Volume -- Physiology
KW - Mining
KW - Adult
KW - China
KW - Male
KW - Prospective Studies
KW - Surveys
KW - Human
SP - 1143
EP - 1148
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 49
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: To investigate the relationship between the development of bronchitic symptoms and the early rapid decline of forced expiratory volume in 1 second (FEV1). METHODS: A two-stage and a mixed model approach were used to analyze data from 260 newly hired Chinese coal miners who completed approximately 5 to 16 health surveys during 3 years. RESULTS: The proportion of miners with onset of bronchitic symptoms was significantly elevated after 11 months of underground mining. Miners with incident symptoms had greater declines in FEV1 compared with those who did not (-65 vs -23 mL/yr, P < 0.05). At 24 months follow-up, FEV1 had declined an average 235 mL among the 26 miners who developed bronchitic symptoms and smoked, compared with a decline of 96 mL among the 132 nonsmoking miners without symptoms. CONCLUSIONS: Among new coal miners, a sharp early decline in FEV1 is associated with the development of bronchitic symptoms.
SN - 1076-2752
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
U2 - PMID: 18000419.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105845574&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - May Chu
AU - Sweis, Luciana E.
AU - Guay, Albert H.
AU - Manski, Richard J.
T1 - The dental care of U.S. children: Access, use and referrals by nondentist providers, 2003.
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
Y1 - 2007/10//
VL - 138
IS - 10
M3 - Article
SP - 1324
EP - 1331
SN - 00028177
AB - The article discusses a study which examined dental care of children in the U.S. The study also examined the role of nondentist practitioners in referring child patients for dental care by analyzing data from the 2003 Medical Expenditure Panel Survey performed by the Agency for Healthcare Research and Quality and the National Center for Health Statistics. The study found that children from families with higher income are more likely to seek dental care than children from low-income families.
KW - CHILDREN -- Dental care
KW - MEDICAL referral
KW - POOR children
KW - CHILDREN of the rich
KW - UNITED States
KW - access
KW - checkup
KW - Dental care
KW - Medical Expenditure Panel Survey
KW - referrals.
KW - utilization
N1 - Accession Number: 27254768; May Chu 1; Email Address: may.chu@ahrq.hhs.gov Sweis, Luciana E. 2 Guay, Albert H. 3 Manski, Richard J. 4; Affiliation: 1: Survey Statistician, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Md. 20850 2: Clinical Assistant Professor. Department of Oral Medicine and Diagnostic Sciences, University of Illinois, Chicago College of Dentistry 3: Chief policy Advisor, American Dental Association, Chicago 4: Senior Scholar, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Md.. and a professor and the director, Division of Health Services Research, Dental School, University of Maryland, Baltimore.; Source Info: Oct2007, Vol. 138 Issue 10, p1324; Subject Term: CHILDREN -- Dental care; Subject Term: MEDICAL referral; Subject Term: POOR children; Subject Term: CHILDREN of the rich; Subject Term: UNITED States; Author-Supplied Keyword: access; Author-Supplied Keyword: checkup; Author-Supplied Keyword: Dental care; Author-Supplied Keyword: Medical Expenditure Panel Survey; Author-Supplied Keyword: referrals.; Author-Supplied Keyword: utilization; Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27254768&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105825652
T1 - The dental care of U.S. children. Access, use and referrals by nondentist providers, 2003.
AU - Chu M
AU - Sweis LE
AU - Guay AH
AU - Manski RJ
Y1 - 2007/10//
N1 - Accession Number: 105825652. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Dental Care. Grant Information: Agency for Healthcare Research and Quality, Rockville, Md. NLM UID: 7503060.
KW - Dental Care for Children -- Utilization
KW - Dental Caries -- Epidemiology
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Referral and Consultation -- Statistics and Numerical Data
KW - Adolescence
KW - Child
KW - Child, Preschool
KW - Dental Care for Children -- Statistics and Numerical Data
KW - Dental Caries -- Ethnology
KW - Female
KW - Funding Source
KW - Health Services Accessibility
KW - Insurance, Dental -- Statistics and Numerical Data
KW - Male
KW - Pediatrics
KW - Poverty
KW - United States
SP - 1324
EP - 1331
JO - Journal of the American Dental Association (JADA)
JF - Journal of the American Dental Association (JADA)
JA - J AM DENT ASSOC
VL - 138
IS - 10
CY - Chicago, Illinois
PB - American Dental Association
AB - BACKGROUND: Improvements in oral health care services have not reached evenly across every segment of American society. The authors examine the role of nondentist practitioners in referring child patients for dental care by analyzing data from the 2003 Medical Expenditure Panel Survey conducted by the Agency for Healthcare Research and Quality and the National Center for Health Statistics. METHODS: The authors provide national estimates of the percentage of the civilian noninstitutionalized population of the United States aged 2 through 17 years who had a dental visit, who had a dental checkup and who received advice from a nondentist health care provider to have a dental checkup. RESULTS: Overall, 38 percent of all poor, near-poor or low-income children and 60 percent of all middle- or high-income children aged 2 through 17 years reported having had a dental checkup during 2003. The authors observed no significant differences between poor, near-poor and low-income children and higher-income children in terms of having been advised by a nondentist health care provider to have a dental checkup. CONCLUSION: Although income may not predict the likelihood of patients' receiving advice from a nondentist health care provider to have a dental checkup, children from families with higher levels of income were more likely to seek dental care than were children from families with lower levels of income. Practice Implications. Efforts to increase access to dental care should aim to maximize the benefit of advice provided by nondentist health care practitioners to receive a dental checkup, so that children from families with limited income are as likely to receive a dental checkup as are children from families with higher levels of income.
SN - 0002-8177
AD - Survey statistician, Cener for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Md. 20850
U2 - PMID: 17908845.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105825652&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Costello, Catherine E.
AU - Contado-Miller, Joy May
AU - Cipollo, John F.
T1 - A Glycomics Platform for the Analysis of Permethylated Oligosaccharide Alditols
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2007/10//
VL - 18
IS - 10
M3 - Article
SP - 1799
EP - 1812
SN - 10440305
AB - This communication reports the development of an LC/MS platform for the analysis of permethylated oligosaccharide alditols that, for the first time, demonstrates routine online oligosaccharide isomer separation of these compounds before introduction into the mass spectrometer. The method leverages a high-resolution liquid chromatography system with the superior fragmentation pattern characteristics of permethylated oligosaccharide alditols that are dissociated under low-energy collision conditions using quadrupole orthogonal time-of-flight (QoTOF) instrumentation and up to pseudo MS3 mass spectrometry. Glycoforms, including isomers, are readily identified and their structures assigned. The isomer-specific spectra include highly informative cross-ring and elimination fragments, branch position specific signatures, and glycosidic bond fragments, thus facilitating linkage, branch, and sequence assignment. The method is sensitive and can be applied using as little as 40 fmol of derivatized oligosaccharide. Because permethylation renders oligosaccharides nearly chemically equivalent in the mass spectrometer, the method is semiquantitative and, in this regard, is comparable to methods reported using high field NMR and capillary electrophoresis. In this postgenomic age, the importance of glycosylation in biological processes has become clear. The nature of many of the important questions in glycomics is such that sample material is often extremely limited, thus necessitating the development of highly sensitive methods for rigorous structural assignment of the oligosaccharides in complex mixtures. The glycomics platform presented here fulfills these criteria and should lead to more facile glycomics analyses. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MASS spectrometers
KW - OLIGOSACCHARIDES
KW - LIQUID chromatography
KW - GEL electrophoresis
N1 - Accession Number: 26680874; Costello, Catherine E. 1 Contado-Miller, Joy May 1 Cipollo, John F. 1,2; Email Address: John.cipollo@fda.hhs.gov; Affiliation: 1: Mass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA 2: Center for Biologics Evaluation and Research, Division of Bacterial, Parasitic and Allergenic Products, Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Oct2007, Vol. 18 Issue 10, p1799; Subject Term: MASS spectrometers; Subject Term: OLIGOSACCHARIDES; Subject Term: LIQUID chromatography; Subject Term: GEL electrophoresis; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jasms.2007.07.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105828919
T1 - Legal status, emotional well-being and subjective health status of Latino immigrants.
AU - Cavazos-Rehg PA
AU - Zayas LH
AU - Spitznagel EL
AU - Cavazos-Rehg, Patricia A
AU - Zayas, Luis H
AU - Spitznagel, Edward L
Y1 - 2007/10//2007 Oct
N1 - Accession Number: 105828919. Language: English. Entry Date: 20080307. Revision Date: 20161114. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: 5T32 HL07456/HL/NHLBI NIH HHS/United States. NLM UID: 7503090.
KW - Emotions
KW - Health Status
KW - Hispanics -- Legislation and Jurisprudence
KW - Hispanics -- Psychosocial Factors
KW - Immigrants -- Legislation and Jurisprudence
KW - Immigrants -- Psychosocial Factors
KW - Stress, Psychological -- Ethnology
KW - Stress, Psychological -- Etiology
KW - Stress, Psychological -- Psychosocial Factors
KW - Adult
KW - Female
KW - Male
KW - Mental Health
KW - Quality of Life
KW - Questionnaires
KW - United States
KW - Human
SP - 1126
EP - 1131
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
JA - J NATL MED ASSOC
VL - 99
IS - 10
CY - New York, New York
PB - Elsevier Science
AB - Among the many stresses that undocumented Latino immigrants experience, worries about their legal status and preoccupation with disclosure and deportation can heighten the risk for emotional distress and impaired quality of health. To better document these effects, this study examined the relationship between deportation concern and emotional and physical well-being among a group of Latino immigrants in a midwestern city. One-hundred-forty-three persons were recruited through community sources. Fifty-six participants (39%) expressed concern with seeking services for fear of deportation, while 87 did not endorse this concern. Measures of emotional distress, Hispanic immigrant stress and subjective health status were administered. Results indicate that Latino immigrants with concerns about deportation are at heightened risk of experiencing negative emotional and health states (particularly anger), Hispanic immigrant stress associated with extrafamilial factors and substandard health status. Findings inform policymakers of culturally relevant stressors of undocumented Latino immigrants that help to create and perpetuate the health and mental health disparities of this group.
SN - 0027-9684
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Department of Psychiatry, Washington University, St. Louis, St. Louis, MO 63110, USA
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Department of Psychiatry, Washington University, St. Louis, St. Louis, MO 63110, USA. pcavazos@im.wustl.edu
U2 - PMID: 17987916.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kunugita, Naoki
AU - Nan Mei
AU - Goncharova, Tatjana
AU - Norimura, Toshiyuki
T1 - MEASUREMENT OF MUTANT FREQUENCY IN T-CELL RECEPTOR (TCR) GENE BY FLOW CYTOMETRY AFTER X-IRRADIATION ON EL-4 MICE LYMPHOMA CELLS.
JO - Journal of Toxicological Sciences
JF - Journal of Toxicological Sciences
Y1 - 2007/10//
VL - 32
IS - 4
M3 - Article
SP - 377
EP - 386
SN - 03881350
AB - It is well known that somatic mutations are induced by ionizing irradiation. We have previously reported the measurement of mutant frequency (MF) on the T-cell receptor (TCR) gene in mouse T-lymphocytes after irradiation by flow cytomery. In this study, we developed an in vitro system using murine EL-4 lymphoma cells and observed frequency of cells defective in TCR gene expression after exposure to ionizing irradiation. EL-4 cells were stained with fluorescein-labeled anti-CD4 and phycoerythrin-labeled anti-CD3 antibodies. They were analyzed with a flow cytometer to detect mutant EL-4 cells lacking surface expression of TCR/CD3 complexes which showed CD3-, CD4+ due to a somatic mutation at the TCR genes. Mutant cells could be observed at 2 days after 3 Gy irradiation. MF of EL-4 cells was 6.7 x 10-4 for 0 Gy and the value increased to the maximum level of 39 x 10-4 between 4 and 8 days after 3 Gy irradiation and these data were found to be best fitted by a linear-quadratic doseresponse model. After the peak value the TCR MF gradually decreased with a half-life of approximately 3.2 days. We also examined the hprt mutant frequencies at seven days after irradiation and the cytokinesis-blocked micronucleus frequency at 20 hrs after irradiation. The frequencies of hprt mutation and micronuclei were found to be best fitted by a linear-quadratic dose-response model and a linear dose-response model, respectively. The method to detect mutation on TCR gene is quick and easy in comparison with other methods and is considered useful for the mutagenicity test. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicological Sciences is the property of Japanese Society of Toxicology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - T-cell receptor genes
KW - FLOW cytometry
KW - IRRADIATION
KW - LYMPHOMAS
KW - MICE as laboratory animals
KW - EL-4 cell
KW - Flow cytometry
KW - Radiation
KW - Somatic mutation
KW - T-cell receptor gene
N1 - Accession Number: 27480449; Kunugita, Naoki 1; Email Address: kunugita@med.uoeh-u.ac.jp Nan Mei 2,3 Goncharova, Tatjana 2 Norimura, Toshiyuki 2; Affiliation: 1: Department of Health Information Science, School of Health Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan 2: Department of Radiation Biology and Health, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan 3: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Oct2007, Vol. 32 Issue 4, p377; Subject Term: MUTATION (Biology); Subject Term: T-cell receptor genes; Subject Term: FLOW cytometry; Subject Term: IRRADIATION; Subject Term: LYMPHOMAS; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: EL-4 cell; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: Somatic mutation; Author-Supplied Keyword: T-cell receptor gene; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Markovitz, Nancy S.
T1 - The Herpes Simplex Virus Type 1 UL3 Transcript Starts within the UL3 Open Reading Frame and Encodes a 224-Amino-Acid Protein.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2007/10//
VL - 81
IS - 19
M3 - Article
SP - 39
EP - 39
SN - 0022538X
AB - Several different herpes simplex viruses (HSVs) and vectors are being explored as therapeutic products for use in the treatment of cancer and neurological disorders. The viral strain and the combination of mutant viral genes that ultimately may serve as a safe and optimal backbone for such products are still being explored. The large genome size and complexity of the viral life cycle make such determinations difficult, because the significance of differences between proposed products is difficult to evaluate. For example, we previously reported that two lineages of γ 34.5-deleted HSVs used in clinical studies differ from each other in the size of the UL3 protein expressed (M. J. Dambach et al., Mol. Ther. 13:891-898, 2006). Because the function of UL3 is not known and UL3 gene expression is poorly understood, the significance of such a difference cannot be predicted. Here, I begin to address the function of UL3 by investigating UL3 gene expression. I report that the transcript start site of UL3 mRNA isolated from HSV type 1 (HSV-1)-infected cells maps to a position downstream of the predicted translation start site. By constructing and characterizing the recombinant virus CB8116, which has a mutation in the first in-frame start codon of this UL3 transcript, I demonstrated that UL3 protein translation initiates at the second in-frame start codon of the UL3 open reading frame. This information adds to the body of basic knowledge of HSV-1 biology that forms the foundation for our current understanding of HSV-based products. Future research on HSV-1 biology will facilitate the rational design and evaluation of future generations of therapeutic viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - MESSENGER RNA
KW - PROTEINS
KW - AMINO acid sequence
KW - GENE expression
N1 - Accession Number: 26713037; Markovitz, Nancy S. 1; Email Address: nancy.markovitz@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Oct2007, Vol. 81 Issue 19, p39; Subject Term: HERPES simplex virus; Subject Term: MESSENGER RNA; Subject Term: PROTEINS; Subject Term: AMINO acid sequence; Subject Term: GENE expression; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.00123-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105829687
T1 - Do HMOs Reduce Preventable Hospitalizations for Medicare Beneficiaries?
AU - Basu J
AU - Mobley LR
Y1 - 2007/10//
N1 - Accession Number: 105829687. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9506850.
KW - Health Maintenance Organizations -- Administration
KW - Hospitalization -- Trends
KW - Medicare -- Administration
KW - Aged
KW - Aged, 80 and Over
KW - Fee for Service Plans
KW - Female
KW - Male
KW - Severity of Illness Indices
KW - United States
KW - Human
SP - 544
EP - 567
JO - Medical Care Research & Review
JF - Medical Care Research & Review
JA - MED CARE RES REV
VL - 64
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - This study assesses the association of HMO enrollment with preventable hospitalizations among the elderly in four states. Using 2001 hospital discharge abstracts for elderly Medicare enrollees (age 65 and above) residing in four states (New York, Pennsylvania, Florida, and California), from the Healthcare Cost and Utilization Project (HCUP-SID) database of the Agency for Healthcare Research and Quality, we use a multivariate cross-sectional design with patient-level data for each state. Holding other factors such as demographics and illness severity constant, we find that in three out of four states, Medicare HMO patients had lower odds of a preventable admission versus marker admission than Medicare fee-for-service (FFS) patients. Moreover, in the two states with longest tenure and greatest Medicare HMO penetration, California and Florida, the reduction in preventable admissions among Medicare HMO patients was mainly concentrated among more ill patients. These findings add to the evidence that managed care outperforms traditional care among the elderly, rather than simply skimming off the healthiest populations.
SN - 1077-5587
AD - Agency for Healthcare Research and Quality; jayasree.basu@ahrq.hhs.gov
U2 - PMID: 17881621.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105829687&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Klinman, Dennis M.
AU - Currie, Debra
AU - Lee, Gloria
AU - Grippe, Vanessa
AU - Merkel, Tod
T1 - Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2007/10//
VL - 9
IS - 12/13
M3 - Article
SP - 1478
EP - 1483
SN - 12864579
AB - Abstract: Improved vaccines and adjuvants are being developed to reduce the threat posed by a terrorist attack involving aerosolized anthrax spores. Nevertheless, uncertainty persists concerning the relative benefits of inducing mucosal vs systemic immunity to host survival following inhalational exposure to anthrax spores. This work examines the effect of delivering the licensed human vaccine (anthrax vaccine adsorbed, AVA) combined with a CpG oligodeoxynucleotide (ODN) adjuvant intraperitoneally or intranasally to A/J mice. Results indicate that protection from inhalational anthrax correlates with the induction of a strong systemic rather than mucosal immune response, and demonstrate that protection is significantly improved and accelerated by the addition of CpG ODN. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical microbiology
KW - Life sciences
KW - Biology
KW - Medical sciences
KW - 50% lethal dose ( LD50 )
KW - Anthrax
KW - anthrax vaccine adsorbed ( AVA )
KW - antibody ( Ab )
KW - antigen ( Ag )
KW - antigen presenting cell ( APC )
KW - bronchioalveolar lavage fluid ( BAL )
KW - oligodeoxynucleotide ( ODN )
KW - Protection
KW - protective antigen ( PA )
KW - Sterne strain anthrax spores ( STI )
KW - Vaccine
N1 - Accession Number: 27356406; Klinman, Dennis M. 1; Email Address: klinmand@mail.nih.gov; Currie, Debra 1; Lee, Gloria 2; Grippe, Vanessa 2; Merkel, Tod 2; Affiliations: 1: Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA; 2: Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Oct2007, Vol. 9 Issue 12/13, p1478; Thesaurus Term: Medical microbiology; Thesaurus Term: Life sciences; Thesaurus Term: Biology; Subject Term: Medical sciences; Author-Supplied Keyword: 50% lethal dose ( LD50 ); Author-Supplied Keyword: Anthrax; Author-Supplied Keyword: anthrax vaccine adsorbed ( AVA ); Author-Supplied Keyword: antibody ( Ab ); Author-Supplied Keyword: antigen ( Ag ); Author-Supplied Keyword: antigen presenting cell ( APC ); Author-Supplied Keyword: bronchioalveolar lavage fluid ( BAL ); Author-Supplied Keyword: oligodeoxynucleotide ( ODN ); Author-Supplied Keyword: Protection; Author-Supplied Keyword: protective antigen ( PA ); Author-Supplied Keyword: Sterne strain anthrax spores ( STI ); Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.micinf.2007.08.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27356406&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huber, A. M.
AU - Dugan, E. M.
AU - Lachenbruch, P. A.
AU - Feldman, B. M.
AU - Perez, M. D.
AU - Zemel, L. S.
AU - Lindsley, C. B.
AU - Rennebohm, R. M.
AU - Wallace, C. A.
AU - Passo, M. H.
AU - Reed, A. M.
AU - Bowyer, S. L.
AU - Ballinger, S. H.
AU - Miller, F. W.
AU - Rider, L. G.
T1 - The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy.
JO - Rheumatology
JF - Rheumatology
Y1 - 2007/10//
VL - 46
IS - 10
M3 - Article
SP - 1606
EP - 1611
SN - 14620324
AB - Objectives. Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Rheumatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLES -- Diseases
KW - JUVENILE diseases
KW - DERMATOMYOSITIS
KW - SKIN diseases
KW - CLINICAL trials
KW - Assessment
KW - Cutaneous Assessment Tool
KW - Juvenile dermatomyositis
KW - Juvenile idiopathic inflammatory myopathy
KW - Skin disease
N1 - Accession Number: 44735761; Huber, A. M. 1; Email Address: adam.huber@iwk.nshealth.ca Dugan, E. M. 2 Lachenbruch, P. A. 3 Feldman, B. M. 4 Perez, M. D. 5 Zemel, L. S. 6 Lindsley, C. B. 7 Rennebohm, R. M. 8 Wallace, C. A. 9 Passo, M. H. 10 Reed, A. M. 11 Bowyer, S. L. 12 Ballinger, S. H. 12 Miller, F. W. 13 Rider, L. G. 13; Affiliation: 1: IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada 2: Washington Hospital Center, Washington, DC 3: Center for Biologics Evaluation and Research, Food and Drug Administration, DHHS, Rockville, MD, USA 4: Hospital For Sick Children and University of Toronto, Toronto, Ontario, Canada 5: Texas Children's Hospital and Baylor College of Medicine, Houston, TX 6: Connecticut Children's Medical Center and University of Connecticut, Hartford, CT 7: University of Kansas, Kansas City, KS 8: Columbus Children's Hospital and Ohio State University, Columbus, OH 9: Children's Hospital and University of Washington, Seattle, WA 10: Children's Hospital and University of Cincinnati, Cincinnati, OH, USA 11: Mayo Clinic, Rochester 12: Riley Children's Hospital and Indiana University School of Medicine, Indianapolis 13: Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, North Carolina; Source Info: Oct2007, Vol. 46 Issue 10, p1606; Subject Term: MUSCLES -- Diseases; Subject Term: JUVENILE diseases; Subject Term: DERMATOMYOSITIS; Subject Term: SKIN diseases; Subject Term: CLINICAL trials; Author-Supplied Keyword: Assessment; Author-Supplied Keyword: Cutaneous Assessment Tool; Author-Supplied Keyword: Juvenile dermatomyositis; Author-Supplied Keyword: Juvenile idiopathic inflammatory myopathy; Author-Supplied Keyword: Skin disease; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1093/rheumatology/kem179
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44735761&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cecala, Andrew
AU - Organiscak, John
AU - Zimmer, Jeanne
AU - Moredock, David
AU - Hillis, Misty
T1 - Closing the Door to Dust when Adding Drill Steels.
JO - Rock Products
JF - Rock Products
Y1 - 2007/10//
VL - 110
IS - 10
M3 - Article
SP - 28
EP - 32
PB - Mining Media Inc.
SN - 00357464
AB - The article presents information on a uni-directional cab filtration and pressurization system that has been tested in an effort to improve the quality of air in older enclosed cabs on mining equipment. It says that the U.S. National Institute for Occupational Safety and Health (NIOSH) has collaborated with the mining industry and manufacturers of cab filtration and pressurization systems for this effort. Accordingly, three days of testing was performed between March 13 and 15, 2007.
KW - FILTERS & filtration
KW - INDUSTRIAL safety
KW - MINERAL industries
KW - INDUSTRIAL equipment
KW - AIR quality management
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 27437457; Cecala, Andrew 1 Organiscak, John 1 Zimmer, Jeanne 2 Moredock, David 3 Hillis, Misty 4; Affiliation: 1: Senior research engineers, National Institute for Occupational Safety and Health 2: Physical Science technician, National Institute for Occupational Safety and Health 3: Vice president, Sy-Klone International 4: Senior health and safety representative, Vulcan Materials Corp.; Source Info: Oct2007, Vol. 110 Issue 10, p28; Subject Term: FILTERS & filtration; Subject Term: INDUSTRIAL safety; Subject Term: MINERAL industries; Subject Term: INDUSTRIAL equipment; Subject Term: AIR quality management; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27437457&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakab, Ferenc
AU - Sebők, Judit
AU - Ferenczi, Emőke
AU - Horváth, Győző
AU - Szűcs, Győrgy
T1 - First detection of Dobrava hantavirus from a patient with severe haemorrhagic fever with renal syndrome by SYBR Green-based real time RT-PCR.
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
Y1 - 2007/10//
VL - 39
IS - 10
M3 - Article
SP - 902
EP - 906
PB - Taylor & Francis Ltd
SN - 00365548
AB - Dobrava hantavirus (DOBV) infection was diagnosed in a previously healthy 46-y-old hunter suffering from severe haemorrhagic fever with renal syndrome (HFRS). Specific IgM antibodies against DOBV were identified by an immunofluorescence assay, while viral nucleic acid was detected by the molecular method, confirming the diagnosis. Our results reveal an existing risk of DOBV transmission to humans in Hungary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Infectious Diseases is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HANTAVIRUS diseases
KW - IMMUNOFLUORESCENCE
KW - PATIENTS
KW - RESEARCH
KW - HEMORRHAGIC fever
KW - IMMUNOGLOBULINS
N1 - Accession Number: 26705827; Jakab, Ferenc 1,2; Email Address: jakabf@gamma.ttk.pte.hu Sebők, Judit 3 Ferenczi, Emőke 4 Horváth, Győző 1 Szűcs, Győrgy 2; Affiliation: 1: Institute of Biology, University of Pécs 2: Baranya County Institute of State Public Health Service, Regional Laboratory of Virology, Pécs 3: Second Department of Medicine and Nephrology, University Hospital, Pécs, Hungary 4: National Centre for Epidemiology, Department of Viral Diagnostics, Reference Laboratory of Viral Zoonozes; Source Info: Oct2007, Vol. 39 Issue 10, p902; Subject Term: HANTAVIRUS diseases; Subject Term: IMMUNOFLUORESCENCE; Subject Term: PATIENTS; Subject Term: RESEARCH; Subject Term: HEMORRHAGIC fever; Subject Term: IMMUNOGLOBULINS; Number of Pages: 5p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1080/00365540701387072
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26705827&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105845730
T1 - First detection of Dobrava hantavirus from a patient with severe haemorrhagic fever with renal syndrome by SYBR Green-based real time RT-PCR.
AU - Jakab F
AU - Sebok J
AU - Ferenczi E
AU - Horváth G
AU - Szucs G
Y1 - 2007/10//
N1 - Accession Number: 105845730. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 0215333.
KW - Hantavirus Infections
KW - Hantavirus
KW - Hemorrhagic Fever with Renal Syndrome
KW - Reverse Transcriptase Polymerase Chain Reaction -- Methods
KW - Antibodies, Viral -- Blood
KW - Evolution
KW - Fluorescent Dyes
KW - Hantavirus Infections -- Physiopathology
KW - Hemorrhagic Fever with Renal Syndrome -- Physiopathology
KW - Immunoglobulins -- Blood
KW - Male
KW - Middle Age
KW - Organic Chemicals
KW - RNA -- Blood
SP - 902
EP - 906
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
JA - SCAND J INFECT DIS
VL - 39
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Dobrava hantavirus (DOBV) infection was diagnosed in a previously healthy 46-y-old hunter suffering from severe haemorrhagic fever with renal syndrome (HFRS). Specific IgM antibodies against DOBV were identified by an immunofluorescence assay, while viral nucleic acid was detected by the molecular method, confirming the diagnosis. Our results reveal an existing risk of DOBV transmission to humans in Hungary.
SN - 0036-5548
AD - From the Institute of Biology, University of Pécs,,Baranya County Institute of State Public Health Service, Regional Laboratory of Virology, Pécs
U2 - PMID: 17852891.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105845730&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kaufman, Carol E.
AU - Shelby, Laura
AU - Mosure, Debra J.
AU - Marrazzo, Jeanne
AU - Wong, David
AU - De Ravello, Lori
AU - Rushing, Stephanie Craig
AU - Warren-Mears, Victoria
AU - Neel, Lisa
AU - Eagle, Sara Jumping
AU - Tulloch, Scott
AU - Romero, Francine
AU - Patrick, Sarah
AU - Cheek, James E.
T1 - Within the Hidden Epidemic: Sexually Transmitted Diseases and HIV/AIDS Among American Indians and Alaska Natives.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2007/10//
VL - 34
IS - 10
M3 - Article
SP - 767
EP - 777
SN - 01485717
AB - The article examines the epidemiology, research and prevention programs for sexually transmitted diseases in American Indians and Alaska Natives (AI/AN). As part of the experimental design, the researchers reviewed the current national and regional trends in sexually transmitted diseases (STD) for AI/ANs from 1998-2004. Based on the results, STD prevalence among AI/ANs remained high such as the case rate of Chlamydia trachomatis in the North Central Plains AI/AN populations was six times the overall U.S. rate.
KW - EPIDEMIOLOGY
KW - SEXUALLY transmitted diseases
KW - SAFE sex
KW - NATIVE Americans
KW - CHLAMYDIA trachomatis
KW - SEXUAL health
KW - PREVENTIVE medicine
KW - EXPERIMENTAL design
KW - UNITED States
N1 - Accession Number: 26925173; Kaufman, Carol E. 1; Email Address: carol.kaufman@uchsc.edu Shelby, Laura 2 Mosure, Debra J. 2 Marrazzo, Jeanne 3 Wong, David 4 De Ravello, Lori 5 Rushing, Stephanie Craig 6 Warren-Mears, Victoria 6 Neel, Lisa 7 Eagle, Sara Jumping 1 Tulloch, Scott 5 Romero, Francine 8 Patrick, Sarah 9 Cheek, James E. 10; Affiliation: 1: American Indian and Alaska Native Programs, University of Colorado, Denver and Health Sciences Center, Aurora, Colorado 2: Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Department of Medicine, University of Washington, Seattle, Washington 4: Division of Epidemiology, Centers for Disease Control and Prevention, Atlanta, Georgia 5: Assignee to the Indian Health Service Division of Epidemiology and Disease Prevention, Centers for Disease Control and Prevention, Albuquerque, New Mexico 6: Northwest Portland Area Indian Health Board, Portland, Oregon 7: Native American Management Services, Inc., Reston, Virginia 8: Albuquerque Area Southwest Tribal Epidemiology Center, Albuquerque Area Indian Health Board, Albuquerque, New Mexico 9: Center for Rural Health Improvement, National Center of Excellence in Women's Health, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota 10: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico; Source Info: Oct2007, Vol. 34 Issue 10, p767; Subject Term: EPIDEMIOLOGY; Subject Term: SEXUALLY transmitted diseases; Subject Term: SAFE sex; Subject Term: NATIVE Americans; Subject Term: CHLAMYDIA trachomatis; Subject Term: SEXUAL health; Subject Term: PREVENTIVE medicine; Subject Term: EXPERIMENTAL design; Subject Term: UNITED States; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1097/01.olq.0000260915.64098.cb
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26925173&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Espandiari, Parvaneh
AU - Zhang, Jun
AU - Rosenzweig, Barry A.
AU - Vaidya, Vishal S.
AU - Jinchun Sun
AU - Schnackenberg, Laura
AU - Herman, Eugene H.
AU - Knapton, Alan
AU - Bonventre, Joseph V.
AU - Beger, Richard D.
AU - Thompson, Karol L.
AU - Hanig, Joseph
T1 - The Utility of a Rodent Model in Detecting Pediatric Drug-Induced Nephrotoxicity.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2007/10//
VL - 99
IS - 2
M3 - Article
SP - 637
EP - 648
SN - 10966080
AB - A multi-age rat model was used to identify potential age-related differences in renal injury following exposure to gentamicin (GM). In this study, 10-, 25-, 40-, and 80-day-old Sprague-Dawley rats were dosed with GM at 0, 50, or 100 mg kg−1 body weight per day (mkd) sc for 6 or 14 days. Urine samples were collected up to 72 h after initial dosing. The maximum tolerated dose was lower in 10-day-old rats than for other ages (none survived 11 days of treatment). Eighty-day-old rats given the highest dose showed a diminished rate of growth and an increase in serum creatinine, blood urea nitrogen (BUN), urinary kidney injury molecule-1 (Kim-1), and renal pathology. Ten- and 40-day-old rats given 100 mkd of GM for 6- or 14 days also had increased levels of serum BUN and Cr and renal pathology, whereas only mild renal alterations were found in 25-day-old rats. After 6 days of treatment with 100 mkd GM, significant increases in Havcr-1 (Kim-1) gene expression were detected only in 10- and 80-day-old rats. In urine samples, nuclear magnetic resonance and ultra performance liquid chromatography/mass spectrometry analysis detected changes related to GM efficacy (e.g., hippurate) and increases in metabolites related to antioxidant activity, which was greatest in the 80-day-old rats. The magnitude of the genomic, metabonomic, and serum chemistry changes appeared to correlate with the degree of nephropathy. These findings indicate that an experimental animal model that includes several developmental stages can detect age-related differences in drug-induced organ toxicities and may be a useful predictor of pediatric drug safety in preclinical studies. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEPHROTOXICOLOGY
KW - DRUGS -- Side effects
KW - RODENTS as laboratory animals
KW - GENTAMICIN
KW - BIOCHEMICAL markers
KW - age-related nephrotoxicity
KW - biomarkers
KW - gentamicin
KW - Kim-1
N1 - Accession Number: 44394004; Espandiari, Parvaneh 1; Email Address: parvaneh.espandiari@fda.hhs.gov Zhang, Jun 1 Rosenzweig, Barry A. 1 Vaidya, Vishal S. 2 Jinchun Sun 3 Schnackenberg, Laura 3 Herman, Eugene H. 1 Knapton, Alan 1 Bonventre, Joseph V. 2 Beger, Richard D. 3 Thompson, Karol L. 1 Hanig, Joseph 1; Affiliation: 1: Center for Drug Evaluation and Research, Silver Spring, Maryland 20993 2: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 3: National Center for Toxicological Research, Jefferson, Arkansas 72079; Source Info: Oct2007, Vol. 99 Issue 2, p637; Subject Term: NEPHROTOXICOLOGY; Subject Term: DRUGS -- Side effects; Subject Term: RODENTS as laboratory animals; Subject Term: GENTAMICIN; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: age-related nephrotoxicity; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: gentamicin; Author-Supplied Keyword: Kim-1; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 12p; Illustrations: 1 Diagram, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfm184
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44394004&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, H.
AU - Campbell, A.
AU - Ali, S. F.
AU - Cong, P.
AU - Bondy, S. C.
T1 - Chronic exposure to low levels of aluminum alters cerebral cell signaling in response to acute MPTP administration.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2007/10//
VL - 23
IS - 9
M3 - Article
SP - 515
EP - 524
PB - Sage Publications, Ltd.
SN - 07482337
AB - Two-month-old male B/6C3F1 mice were treated for 10 weeks with 100 μM aluminum lactate (Al) in drinking water. This dose of Al did not alter body weight, and there was no evidence of systemic toxicity. The degree of phosphorylation of several kinases which lead to transcription l:actor activation (reflecting the extent of their activation) was studied. The proportion of extracellular signal-regulated kinase (ERK) that was activated was depressed in cortex but not in the hippocampus following treatment bat c-Jun N-terminal kinase (JNK), p38, IκB phosphorylation was unaltered in either tissue. Treatment of mice with 1-methyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) alone produced no significant changes in the degree of activation of any transcription factor studied. When MPTP dosing had been preceded by extended exposure to low levels of A1 in drinking water, ERK activation was profoundly depressed in cortex and hippocampus, whereas JNK in hippocampos and IκB in cortex were greatly elevated. These changes consequent to exposure to both A1 and MPTP were accompanied by an increase in NF-κB in both regions, whereas AP-1 was elevated in the hippocampus alone. Neither agent alone modulated AP-1 or NF-κB. Thus a synergistic interaction occurred between the toxicants. This interaction tended to promote the functioning of a kinase largely associated with inflammation and to depress that of ERK, which is associated with maintenance of cell survival. It is concluded that exposure to levels of A1 with no evident toxicity can worsen the response to an acute challenge with MPTP. A1 treatment alone was able to increase striatal 3,4-dihydroxyphenylacetic acid levels, suggesting an elevation of the rate of dopamine turnover in the striatum. However, no interaction in alteration of monoamine levels was found between A1 and MPTP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aluminum
KW - Drinking water
KW - Lactates
KW - Body weight
KW - Phosphorylation
KW - Methylphenyltetrahydropyridine
KW - Transcription factors
KW - aluminum
KW - cell signaling
KW - inflammation
KW - MPTP
N1 - Accession Number: 33917766; Li, H. 1; Campbell, A. 2; Ali, S. F. 3; Cong, P. 1; Bondy, S. C. 1; Email Address: scbondy@uci.edu; Affiliations: 1: Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, California, USA; 2: Pharmaceutical Sciences, Western University of Health Sciences, Pomona, California, USA; 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas, USA; Issue Info: Oct2007, Vol. 23 Issue 9, p515; Thesaurus Term: Aluminum; Thesaurus Term: Drinking water; Subject Term: Lactates; Subject Term: Body weight; Subject Term: Phosphorylation; Subject Term: Methylphenyltetrahydropyridine; Subject Term: Transcription factors; Author-Supplied Keyword: aluminum; Author-Supplied Keyword: cell signaling; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: MPTP; NAICS/Industry Codes: 331318 Other Aluminum Rolling, Drawing, and Extruding; NAICS/Industry Codes: 331317 Aluminum rolling, drawing, extruding and alloying; NAICS/Industry Codes: 331314 Secondary Smelting and Alloying of Aluminum; NAICS/Industry Codes: 331313 Alumina Refining and Primary Aluminum Production; Number of Pages: 10p; Illustrations: 2 Color Photographs, 1 Black and White Photograph, 1 Diagram, 10 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33917766&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2007-14602-001
AN - 2007-14602-001
AU - Salvatore, Scott J.
AU - Smelson, David A.
AU - Kline, Anna
AU - Sussner, Bradley
AU - Faust, Erik
AU - Lee, Seung Min
T1 - The role of cognition, impulsivity, and age in program violations in a federal prison substance abuse treatment facility: A preliminary report.
JF - Journal of Correctional Health Care
JO - Journal of Correctional Health Care
JA - J Correct Health Care
Y1 - 2007/10//
VL - 13
IS - 4
SP - 252
EP - 256
CY - US
PB - Sage Publications
SN - 1078-3458
SN - 1940-5200
AD - Salvatore, Scott J., 5130 La Jolla Boulevard, Apartment 2A, San Diego, CA, US, 92109
N1 - Accession Number: 2007-14602-001. Partial author list: First Author & Affiliation: Salvatore, Scott J.; U.S. Public Health Service, San Diego, CA, US. Release Date: 20071217. Correction Date: 20111107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognition; Drug Rehabilitation; Impulsiveness; Prisoners; Treatment Compliance. Minor Descriptor: Drug Abuse; Prisons; Treatment Outcomes. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Jackson Impulsivity Scale; Wechsler Adult Intelligence Scale (WAIS); Trail Making Test DOI: 10.1037/t00757-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 2007.
AB - Few studies have examined the role of cognition and outcomes among substance abusers in prison settings. To extend the literature, this study examined the relationship among cognition, impulsivity, and the incidence of program violations in a federal substance abuse treatment program. One hundred and twenty individuals entering a federal drug treatment program underwent a brief screening battery. Participants were administered the Trail Making Tests Parts A and B, Digit Symbol subtests, and the Jackson impulsivity tests. This study failed to find a relationship between cognition, impulsivity, and program violations. The study did, however, find a significant relationship between age and program violations. These findings suggest that being younger is a risk factor for program violations within the substance abuse treatment program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cognition
KW - impulsivity
KW - age
KW - federal prisoners
KW - substance abuse
KW - treatment facility
KW - program violations
KW - prisons
KW - 2007
KW - Cognition
KW - Drug Rehabilitation
KW - Impulsiveness
KW - Prisoners
KW - Treatment Compliance
KW - Drug Abuse
KW - Prisons
KW - Treatment Outcomes
KW - 2007
DO - 10.1177/1078345807306961
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-14602-001&site=ehost-live&scope=site
UR - scott.salvatore@dhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13134-004
AN - 2007-13134-004
AU - Detera-Wadleigh, Sevilla D.
AU - Liu, Chun-yu
AU - Maheshwari, Manjula
AU - Cardona, Imer
AU - Corona, Winston
AU - Akula, Nirmala
AU - Steele, C. J. M.
AU - Badner, Judith A.
AU - Kundu, Mukta
AU - Kassem, Layla
AU - Potash, James B.
AU - Gibbs, Richard
AU - Gershon, Elliot S.
AU - McMahon, Francis J.
T1 - Sequence variation in DOCK9 and heterogeneity in bipolar disorder.
JF - Psychiatric Genetics
JO - Psychiatric Genetics
JA - Psychiatr Genet
Y1 - 2007/10//
VL - 17
IS - 5
SP - 274
EP - 286
CY - US
PB - Lippincott Williams & Wilkins
SN - 0955-8829
SN - 1473-5873
AD - Detera-Wadleigh, Sevilla D., NIMH, NIH, Building 35 Room 1A205, 35 Convent Drive, Bethesda, MD, US, 20892-3719
N1 - Accession Number: 2007-13134-004. PMID: 17728666 Partial author list: First Author & Affiliation: Detera-Wadleigh, Sevilla D.; Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Institutional Authors: NIMH Genetics Initiative for Bipolar Disorder Consortium. Release Date: 20071015. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: McMahon, Francis J. Major Descriptor: Bipolar Disorder; Chromosomes; Genetics; Phenotypes. Minor Descriptor: Etiology; Genes; Genome; Pathophysiology. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Diagnostic Instrument for Genetic Studies; Schedule for Affective Disorders and Schizophrenia-Lifetime version. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 2007.
AB - Background: Linkage of bipolar disorder to a broad region on chromosome 13q has been supported in several studies including a meta-analysis on genome scans. Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region. Objective: To identify additional susceptibility loci on 13q32-q33 by linkage disequilibrium mapping and explore the impact of phenotypic heterogeneity on association. Methods: In the initial phase, 98 single nucleotide polymorphism (SNPs) located on 13q32-q33 were genotyped on 285 probands with bipolar disorder and their parents were drawn from families in the NIMH Genetics Initiative consortium for bipolar disorder (NIMH1-4) and two other series. Fine scale mapping using one family series (NIMH1-2) as the test sample was targeted on a gene that displayed the highest evidence of association. A secondary analysis of familial component phenotypes of bipolar disorder was conducted. Results: Three of seven SNPs in DOCK9, a gene that encodes an activator of the Rho-GTPase Cdc42, showed significant excess allelic transmission (P = 0.0477-0.00067). Fine scale mapping on DOCK9 yielded evidence of association at nine SNPs in the gene (P = 0.02-0.006). Follow-up tests detected excess transmission of the same allele of rs1340 in two out of three other sets of families. The association signals were largely attributable to maternally transmitted alleles (rs1927568: P = 0.000083; odds ratio = 3.778). A secondary analysis of familial component phenotypes of bipolar disorder detected significant association across multiple DOCK9 markers for racing thoughts, psychosis, delusion during mania and course of illness indicators. Conclusion: These results suggest that DOCK9 contributes to both risk and increased illness severity in bipolar disorder. We found evidence for the effect of phenotypic heterogeneity on association. To our knowledge this is the first report to implicate DOCK9 or the Rho-GTPase pathway in the etiology of bipolar disorder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - phenotypic heterogeneity
KW - bipolar disorder
KW - genome
KW - chromosomes
KW - 2007
KW - Bipolar Disorder
KW - Chromosomes
KW - Genetics
KW - Phenotypes
KW - Etiology
KW - Genes
KW - Genome
KW - Pathophysiology
KW - 2007
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program. Recipients: McMahon, Francis J. (Prin Inv)
U1 - Sponsor: National Institute of Mental Health. Other Details: Collaborating R01 awards. Recipients: Gershon, Elliot S.; Potash, James B.
DO - 10.1097/YPG.0b013e328133f352
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13134-004&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - deteras@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08099-006
AN - 2008-08099-006
AU - Nicholson, Joanne
AU - Hinden, Beth R.
AU - Biebel, Kathleen
AU - Henry, Alexis D.
AU - Katz-Leavy, Judith
T1 - A qualitative study of programs for parents with serious mental illness and their children: Building practice-based evidence.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2007/10//
VL - 34
IS - 4
SP - 395
EP - 413
CY - Germany
PB - Springer
SN - 1094-3412
AD - Nicholson, Joanne, Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, US, 01655
N1 - Accession Number: 2008-08099-006. PMID: 17503187 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Nicholson, Joanne; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20081208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Research Conference for Children's Mental Health, 15th, Mar, 2002, Tampa, FL, US. Conference Note: Data from this article were presented at the aforementioned conference. Major Descriptor: Child Psychiatry; Child Psychology; Chronic Mental Illness; Evidence Based Practice; Mental Health Services. Minor Descriptor: Parents. Classification: Health & Mental Health Services (3370). Population: Human (10). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Oct, 2007.
AB - The rationale for the development of effective programs for parents with serious mental illness and their children is compelling. Using qualitative methods and a grounded theory approach with data obtained in site visits, seven existing programs for parents with mental illness and their children in the United States are described and compared across core components: target population, theory and assumptions, funding, community and agency contexts, essential services and intervention strategies, moderators, and outcomes. The diversity across programs is strongly complemented by shared characteristics, the identification of which provides the foundation for future testing and the development of an evidence base. Challenges in program implementation and sustainability are identified. Qualitative methods are useful, particularly when studying existing programs, in taking steps toward building the evidence base for effective programs for parents with serious mental illness and their children. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serious mental illness
KW - mental health programs
KW - parents
KW - children
KW - evidence based practice
KW - 2007
KW - Child Psychiatry
KW - Child Psychology
KW - Chronic Mental Illness
KW - Evidence Based Practice
KW - Mental Health Services
KW - Parents
KW - 2007
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: CMHS-99M00481801D. Recipients: No recipient indicated
DO - 10.1007/s11414-007-9063-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08099-006&site=ehost-live&scope=site
UR - jkatzleavy@gmail.com
UR - Alexis.Henry@Umassmed.edu
UR - Kathleen.Biebel@Umassmed.edu
UR - bhinden@rcn.com
UR - Joanne.Nicholson@Umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-15057-003
AN - 2007-15057-003
AU - Basu, Jayasree
AU - Mobley, Lee R.
T1 - Do HMOs reduce preventable hospitalizations for medicare beneficiaries?
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2007/10//
VL - 64
IS - 5
SP - 544
EP - 567
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
AD - Basu, Jayasree, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-15057-003. PMID: 17881621 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Basu, Jayasree; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Conference of the American Society of Health Economists (ASHE), 2006, Madison, WI, US. Grant Information: Basu, Jayasree. Major Descriptor: Aging; Health Maintenance Organizations; Hospitalization; Medicare; Prevention. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 24. Issue Publication Date: Oct, 2007.
AB - This study assesses the association of HMO enrollment with preventable hospitalizations among the elderly in four states. Using 2001 hospital discharge abstracts for elderly Medicare enrollees (age 65 and above) residing in four states (New York, Pennsylvania, Florida, and California), from the Healthcare Cost and Utilization Project (HCUP-SID) database of the Agency for Healthcare Research and Quality, we use a multivariate cross-sectional design with patient-level data for each state. Holding other factors such as demographics and illness severity constant, we find that in three out of four states, Medicare HMO patients had lower odds of a preventable admission versus marker admission than Medicare fee-for-service (FFS) patients. Moreover, in the two states with longest tenure and greatest Medicare HMO penetration, California and Florida, the reduction in preventable admissions among Medicare HMO patients was mainly concentrated among more ill patients. These findings add to the evidence that managed care outperforms traditional care among the elderly, rather than simply skimming off the healthiest populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health maintenance organizations
KW - preventable hospitalizations
KW - medicare beneficiaries
KW - elderly
KW - 2007
KW - Aging
KW - Health Maintenance Organizations
KW - Hospitalization
KW - Medicare
KW - Prevention
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: Basu, Jayasree; Mobley, Lee R.
U1 - Sponsor: RTI International. Recipients: Basu, Jayasree; Mobley, Lee R.
DO - 10.1177/1077558707301955
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-15057-003&site=ehost-live&scope=site
UR - jayasree.basu@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17975-001
AN - 2007-17975-001
AU - Dickerson, Anne E.
AU - Molnar, Lisa J.
AU - Eby, David W.
AU - Adler, Geri
AU - Bédard, Michel
AU - Berg-Weger, Marla
AU - Classen, Sherrilene
AU - Foley, Daniel
AU - Horowitz, Amy
AU - Kerschner, Helen
AU - Page, Oliver
AU - Silverstein, Nina M.
AU - Staplin, Loren
AU - Trujillo, Leonard
T1 - Transportation and aging: A research agenda for advancing safe mobility.
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2007/10//
VL - 47
IS - 5
SP - 578
EP - 590
CY - US
PB - Gerontological Society of America
SN - 0016-9013
SN - 1758-5341
AD - Dickerson, Anne E., Department of Occupational Therapy, East Carolina University, Health Sciences Building Room 3305, Greenville, NC, US, 27858
N1 - Accession Number: 2007-17975-001. PMID: 17989400 Partial author list: First Author & Affiliation: Dickerson, Anne E.; Department of Occupational Therapy, East Carolina University, Greenville, NC, US. Other Publishers: Oxford University Press. Release Date: 20080211. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Aging; Drivers; Evaluation; Highway Safety; Rehabilitation. Minor Descriptor: Screening. Classification: Gerontology (2860); Transportation (4090). Population: Human (10). Location: North America. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Literature Review. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 2007.
AB - Purpose: We review what we currently know about older driver safety and mobility, and we highlight important research needs in a number of key areas that hold promise for achieving the safety and mobility goals for the aging baby boomers and future generations of older drivers. Design and Methods: Through the use of a framework for transportation and safe mobility, we describe key areas of screening and assessment, remediation and rehabilitation, vehicle design and modification, technological advancements, roadway design, transitioning to nondriving, and alternative transportation to meet the goals of crash prevention and mobility maintenance for older adults. Results: Four cross-cutting themes emerged from this review: safe transportation for older adults is important; older adults have a variety of needs, abilities, and resources; research to help meet the transportation needs of older adults may be of benefit to persons with disabilities; and transportation issues concerning older adults are multifaceted. Implications: Safe mobility is essential to continued engagement in civic, social, and community life, and to the human interactions necessary for health, well-being, and quality of life. When safe driving is no longer possible for older adults, safe and practicable alternative transportation must be available. Furthermore, older adults are individuals; they have specific needs, abilities, and resources. Not all older adults will have difficulty meeting their transportation needs and no single transportation solution will work for all people. Research and countermeasures intended to help meet the transportation needs of older adults will likely also benefit younger users of the transportation system, particularly those with disabilities. The issues surrounding the maintenance of safe transportation for older adults will require an interdisciplinary research approach if we are to make significant progress in the next decade as the baby boomers begin to reach age 70. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - transportation
KW - aging
KW - safe mobility
KW - older driver safety
KW - screening
KW - assessment
KW - remediation
KW - rehabilitation
KW - 2007
KW - Aging
KW - Drivers
KW - Evaluation
KW - Highway Safety
KW - Rehabilitation
KW - Screening
KW - 2007
DO - 10.1093/geront/47.5.578
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17975-001&site=ehost-live&scope=site
UR - dickersona@ecu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18171-007
AN - 2007-18171-007
AU - Joseph, Antony
AU - Punch, Jerry
AU - Stephenson, Mark
AU - Paneth, Nigel
AU - Wolfe, Edward
AU - Murphy, William
T1 - The effects of training format on earplug performance.
JF - International Journal of Audiology
JO - International Journal of Audiology
JA - Int J Audiol
Y1 - 2007/10//
VL - 46
IS - 10
SP - 609
EP - 618
CY - US
PB - Informa Healthcare
SN - 1499-2027
SN - 1708-8186
AD - Joseph, Antony, Chatham Village, Fleming Island, FL, US, 32003
N1 - Accession Number: 2007-18171-007. PMID: 17922350 Partial author list: First Author & Affiliation: Joseph, Antony; Department of Communicative Sciences and Disorders, Michigan State University, East Lansing, MI, US. Other Publishers: Taylor & Francis. Release Date: 20080331. Correction Date: 20150921. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Conference Information: National Hearing Conservation Association 31st Annual Hearing Conservation Conference, 31st, Feb, 2006, Tampa, FL, US. Major Descriptor: Auditory Thresholds; Safety Devices; Training. Minor Descriptor: Hearing Disorders; Prevention. Classification: Health & Mental Health Treatment & Prevention (3300); Vision & Hearing & Sensory Disorders (3299). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2007.
AB - This experiment investigated the effect of small-group versus individual hearing loss prevention (HLP) training on the attenuation performance of passive insert-type hearing protection devices (HPDs). A subject-fit (SF) methodology, which gave naive listeners access only to the instructions printed on the HPD product label, was used to determine real-ear attenuation at threshold (REAT) at third-octave noise bands between 125-8000 Hz. REAT measurements were augmented by use of the Hearing Loss Prevention Attitude-Belief (HLPAB) survey, a field-tested self-assessment tool developed by the National Institute for Occupational Safety and Health (NIOSH). Participants were randomly assigned to one of four experimental groups, consisting of 25 listeners each, in a controlled behavioral-intervention trial. There were two types of HPDs (formable and premolded) and two training formats (individual and small group). A short multimedia program, including a practice session, was presented to all 100 listeners. Results showed training to have a significant effect, for both HPDs on real-ear attenuation and attitude, but, importantly, there was no difference between small-group and individual training. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hearing loss prevention
KW - attenuation
KW - earplugs
KW - training
KW - attitude
KW - small-group vs. individual
KW - 2007
KW - Auditory Thresholds
KW - Safety Devices
KW - Training
KW - Hearing Disorders
KW - Prevention
KW - 2007
DO - 10.1080/14992020701438805
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18171-007&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8551-4646
UR -
UR - earsafety@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16482-005
AN - 2007-16482-005
AU - Cavazos-Rehg, Patricia A.
AU - Zayas, Luis H.
AU - Spitznagel, Edward L.
T1 - Legal status, emotional well-being and subjective health status of Latino immigrants.
JF - Journal of the National Medical Association
JO - Journal of the National Medical Association
JA - J Natl Med Assoc
Y1 - 2007/10//
VL - 99
IS - 10
SP - 1126
EP - 1131
CY - US
PB - National Medical Assn
SN - 0027-9684
SN - 1943-4693
AD - Cavazos-Rehg, Patricia A., Department of Psychiatry, Campus Box 1834, 660 S. Euclid, St. Louis, MO, US, 63110
N1 - Accession Number: 2007-16482-005. PMID: 17987916 Partial author list: First Author & Affiliation: Cavazos-Rehg, Patricia A.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Other Publishers: Elsevier Science. Release Date: 20080121. Correction Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Distress; Immigration; Mental Health; Well Being; Latinos/Latinas. Minor Descriptor: Legal Processes; Urban Environments. Classification: Social Processes & Social Issues (2900). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Emotional Distress Scale; Hispanic Stress Inventory DOI: 10.1037/t00961-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2007.
AB - Among the many stresses that undocumented Latino immigrants experience, worries about their legal status and preoccupation with disclosure and deportation can heighten the risk for emotional distress and impaired quality of health. To better document these effects, this study examined the relationship between deportation concern and emotional and physical well-being among a group of Latino immigrants in a midwestern city. One-hundred-forty-three persons were recruited through community sources. Fifty-six participants (39%) expressed concern with seeking services for fear of deportation, while 87 did not endorse this concern. Measures of emotional distress, Hispanic immigrant stress and subjective health status were administered. Results indicate that Latino immigrants with concerns about deportation are at heightened risk of experiencing negative emotional and health states (particularly anger), Hispanic immigrant stress associated with extrafamilial factors and substandard health status. Findings inform policymakers of culturally relevant stressors of undocumented Latino immigrants that help to create and perpetuate the health and mental health disparities of this group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - legal status
KW - preoccupation
KW - emotional distress
KW - quality of health
KW - Hispanics
KW - immigration
KW - urban environments
KW - 2007
KW - Distress
KW - Immigration
KW - Mental Health
KW - Well Being
KW - Latinos/Latinas
KW - Legal Processes
KW - Urban Environments
KW - 2007
U1 - Sponsor: National Heart, Lung, and Blood Institute. Grant: 5 T32 HL07456. Other Details: Edwin B. Fisher. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16482-005&site=ehost-live&scope=site
UR - pcavazos@im.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19255-009
AN - 2007-19255-009
AU - Hicks, P. L.
AU - Mulvey, K. P.
AU - Chander, G.
AU - Fleishman, J. A.
AU - Josephs, J. S.
AU - Korthuis, P. T.
AU - Hellinger, J.
AU - Gaist, P.
AU - Gebo, K. A.
T1 - The impact of illicit drug use and substance abuse treatment on adherence to HAART.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2007/10//
VL - 19
IS - 9
SP - 1134
EP - 1140
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Gebo, K. A., Johns Hopkins University, School of Medicine, 1830 E. Monument St., Room 442, Baltimore, MD, US, 21287
N1 - Accession Number: 2007-19255-009. PMID: 18058397 Partial author list: First Author & Affiliation: Hicks, P. L.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, US. Institutional Authors: HIV Research Network. Release Date: 20080128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Binge Drinking; Drug Abuse; Drug Rehabilitation; Drug Therapy; Treatment Compliance. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2007.
AB - High levels of adherence to highly active antiretroviral therapy (HAART) are essential for virologic suppression and longer survival in patients with HIV. We examined the effects of substance abuse treatment, current versus former substance use, and hazardous/binge drinking on adherence to HAART. During 2003, 659 HIV patients on HAART in primary care were interviewed. Adherence was defined as 95% adherence to all antiretroviral medications. Current substance users used illicit drugs and/or hazardous/binge drinking within the past six months, while former users had not used substances for at least six months. Logistic regression analyses of adherence to HAART included demographic, clinical and substance abuse variables. Sixty-seven percent of the sample reported 95% adherence or greater. However, current users (60%) were significantly less likely to be adherent than former (68%) or never users (77%). In multivariate analysis, former users in substance abuse treatment were as adherent to HAART as never users (Adjusted Odds Ratio (AOR) = 0.82; p > 0.5). In contrast, former users who had not received recent substance abuse treatment were significantly less adherent than never users (AOR = 0.61; p = 0.05). Current substance users were significantly less adherent than never users, regardless of substance abuse treatment (p < 0.01). Substance abuse treatment interacts with current versus former drug use status to affect adherence to HAART. Substance abuse treatment may improve HAART adherence for former substance users. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - illicit drug use
KW - substance abuse treatment
KW - adherence
KW - highly active antiretroviral therapy
KW - binge drinking
KW - 2007
KW - Binge Drinking
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Drug Therapy
KW - Treatment Compliance
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290-01-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse. Grant: K23-DA00523. Recipients: No recipient indicated
DO - 10.1080/09540120701351888
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19255-009&site=ehost-live&scope=site
UR - kgebo@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-13518-009
AN - 2007-13518-009
AU - Li, Ting-Kai
AU - Hewitt, Brenda G.
AU - Grant, Bridget F.
T1 - The Alcohol Dependence Syndrome, 30 years later--A response to the commentaries.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2007/10//
VL - 102
IS - 10
SP - 1537
EP - 1538
CY - United Kingdom
PB - Blackwell Publishing
SN - 0965-2140
SN - 1360-0443
AD - Hewitt, Brenda G., National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US, 20892-9304
N1 - Accession Number: 2007-13518-009. Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Li, Ting-Kai; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20071001. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Alcohol Abuse; Alcohol Drinking Patterns; Alcoholism; Diagnosis; Syndromes. Minor Descriptor: Diagnostic Criteria. Classification: Substance Abuse & Addiction (3233). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Oct, 2007.
AB - Reply by the current author to the comments made by John R. Hughes (see record [rid]2007-13518-004[/rid]), Mark Dickerson (see record [rid]2007-13518-005[/rid]), Gerhard Bühringer (see record [rid]2007-13518-006[/rid]), Thomas F. Babor (see record [rid]2007-13518-007[/rid]) and Deborah Hasin (see record [rid]2007-13518-008[/rid]) on the original article (see record [rid]2007-13518-003[/rid]). In this paper we could provide only a flavour of the myriad of alcohol research advances since 1976, which we have attributed to the seminal publication by Edwards and Gross (1976) on the alcohol dependence syndrome. We addressed the mounting strength of evidence that alcohol use disorders as categorized currently by the DSM-IV do not have two separate dimensions, but fall along a single continuum of severity of AUD that can be scaled and measured much as other complex diseases. In the subject commentary, we also alluded to the continuum of AUD severity in relation to the quantity, frequency and pattern of drinking as a context for future research. As the DSM and the ICD are poised for revision, we hope that this commentary will stimulate further the science needed to further improve our understanding of alcohol use disorders and to inform clinical decision-making and public health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol dependence syndrome
KW - alcohol abuse
KW - diagnostic criteria
KW - alcohol use disorders
KW - 2007
KW - Alcohol Abuse
KW - Alcohol Drinking Patterns
KW - Alcoholism
KW - Diagnosis
KW - Syndromes
KW - Diagnostic Criteria
KW - 2007
DO - 10.1111/j.1360-0443.2007.02005.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-13518-009&site=ehost-live&scope=site
UR - bhewitt@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105545884
T1 - Drug use patterns and trends in rural communities.
AU - Gfroerer JC
AU - Larson SL
AU - Colliver JD
Y1 - 2007/10/02/Fall2007 Supplement 1
N1 - Accession Number: 105545884. Language: English. Entry Date: 20090417. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Fall2007 Supplement 1. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Pediatric Care; Public Health. NLM UID: 8508122.
KW - Rural Areas
KW - Substance Abuse -- Epidemiology -- In Adolescence
KW - Adolescence
KW - Adult
KW - Alcohol Drinking -- Epidemiology
KW - Audiorecording
KW - Cannabis -- Administration and Dosage
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Probability Sample
KW - Smoking -- Epidemiology
KW - Survey Research
KW - T-Tests
KW - Human
SP - 10
EP - 15
JO - Journal of Rural Health
JF - Journal of Rural Health
JA - J RURAL HEALTH
VL - 23
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0890-765X
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD
U2 - PMID: 18237319.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105545884&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105869248
T1 - Creating and synthesizing evidence with decision makers in mind: integrating evidence from clinical trials and other study designs.
AU - Atkins D
Y1 - 2007/10/02/2007 Oct Supplement 2
N1 - Accession Number: 105869248. Language: English. Entry Date: 20080321. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2007 Oct Supplement 2. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0230027.
KW - Decision Making
KW - Drug Evaluation
KW - Health Policy
KW - Medical Practice, Evidence-Based -- Methods
KW - Study Design
KW - Aspirin -- Therapeutic Use
KW - Cardiovascular Diseases -- Prevention and Control
KW - Clinical Trials
KW - Endarterectomy, Carotid
KW - Female
KW - Fibrinolytic Agents -- Therapeutic Use
KW - Middle Age
KW - Observational Methods
KW - Stroke -- Prevention and Control
KW - United States
SP - S16
EP - 22
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Randomized controlled trials (RCTs) remain the accepted 'gold standard' for determining the efficacy of new drugs or medical procedures. Randomized trials alone, however, cannot provide all the relevant information decision makers need to determine the relative risks and benefits when choosing the best treatment of individual patients or weighing the implications of particular policies affecting medical therapies. OBJECTIVES: To demonstrate the limitations of RCTs in providing the information needed by medical decision makers, and to show how information from observational studies can supplement evidence from RCTs. METHODS: Qualitative description of the limitations of RCTs in providing the information needed by medical decision makers, and demonstration of how evidence from additional sources can aid in decision making, using the examples of deciding whether a 60-year-old woman with mildly elevated blood pressure should take daily low-dose aspirin, and whether a hospital network should implement carotid artery surgery for asymptomatic patients. CONCLUSIONS: Even the most rigorously designed RCTs leave many questions central to medical decision making unanswered. Research using cohort and case-control designs, disease and intervention registries, and outcomes studies based on administrative data can all shed light on who is most likely to benefit from the treatment, and what the important tradeoffs are. This suggests the need to revise the traditional evidence hierarchy, whereby evidence progresses linearly from basic research to rigorous RCTs. This revised hierarchy recognizes that other research designs can provide important evidence to strengthen our understanding of how to apply research findings in practice.
SN - 0025-7079
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 17909376.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105869248&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105869252
T1 - Improving depiction of benefits and harms: analyses of studies of well-known therapeutics and review of high-impact medical journals.
AU - Sedrakyan A
AU - Shih C
Y1 - 2007/10/02/2007 Oct Supplement 2
N1 - Accession Number: 105869252. Language: English. Entry Date: 20080321. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2007 Oct Supplement 2. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0230027.
KW - Communication
KW - Decision Making
KW - Drug Evaluation
KW - Literature
KW - Medical Practice, Evidence-Based
KW - Antipsychotic Agents -- Adverse Effects
KW - Appetite Depressants -- Adverse Effects
KW - Aspirin -- Therapeutic Use
KW - Contraceptives, Oral -- Adverse Effects
KW - Dipyridamole -- Therapeutic Use
KW - Drug Combinations
KW - Epidemiology
KW - Fibrinolytic Agents -- Therapeutic Use
KW - Hormone Replacement Therapy -- Adverse Effects
KW - Phenylpropanolamine -- Adverse Effects
KW - Risk Assessment
KW - Stroke -- Chemically Induced
KW - Stroke -- Epidemiology
KW - Stroke -- Therapy
KW - Tissue Plasminogen Activator -- Therapeutic Use
SP - S23
EP - 8
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - The issues of weighing benefits and harms and of shared decision-making have become increasingly important in recent years. There is limited knowledge and lack of adequate data on the most transparent method of communicating the information. In this article we discuss examples of communicating benefits and harms for well-known therapeutics, illustrating that relative risk estimates are not helpful for communicating the chance of experiencing adverse events. In addition, we show that asymmetric presentation of the data for benefits and harms is likely to bias toward showing greater benefits and diminishing the importance of the harms (or vice versa). We also present preliminary results of a brief review of high-impact medical journals that show limitations of current systematic reviews. In the review we found that every second published study does not discuss frequency data and 1 in 3 studies that report information on both benefits and harms does not report information in the same metric. We conclude that consistently depicting benefit and harm information in frequencies can substantially improve the communication of benefits and harms. Investigators should be requested to provide frequency data along with relative risk information in the publication of their scientific findings. Currently, even in the highest impact medical journals, evidence of benefits and harms is not consistently presented in ways that facilitate accurate interpretation.
SN - 0025-7079
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 17909378.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105869252&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thybaud, Véronique
AU - Aardema, Marilyn
AU - Casciano, Daniel
AU - Dellarco, Vicki
AU - Embry, Michelle R.
AU - Gollapudi, B. Bhaskar
AU - Hayashi, Makoto
AU - Holsapple, Michael P.
AU - Jacobson-Kram, David
AU - Kasper, Peter
AU - MacGregor, James T.
AU - Rees, Robert
T1 - Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2007/10/04/
VL - 633
IS - 2
M3 - Article
SP - 67
EP - 79
SN - 13835718
AB - Abstract: In vitro genotoxicity assays are often used to screen and predict whether chemicals might represent mutagenic and carcinogenic risks for humans. Recent discussions have focused on the high rate of positive results in in vitro tests, especially in those assays performed in mammalian cells that are not confirmed in vivo. Currently, there is no general consensus in the scientific community on the interpretation of the significance of positive results from the in vitro genotoxicity assays. To address this issue, the Health and Environmental Sciences Institute (HESI), held an international workshop in June 2006 to discuss the relevance and follow-up of positive results in in vitro genetic toxicity assays. The goals of the meeting were to examine ways to advance the scientific basis for the interpretation of positive findings in in vitro assays, to facilitate the development of follow-up testing strategies and to define criteria for determining the relevance to human health. The workshop identified specific needs in two general categories, i.e., improved testing and improved data interpretation and risk assessment. Recommendations to improve testing included: (1) re-examine the maximum level of cytotoxicity currently required for in vitro tests; (2) re-examine the upper limit concentration for in vitro mammalian studies; (3) develop improved testing strategies using current in vitro assays; (4) define criteria to guide selection of the appropriate follow-up in vivo studies; (5) develop new and more predictive in vitro and in vivo tests. Recommendations for improving interpretation and assessment included: (1) examine the suitability of applying the threshold of toxicological concern concepts to genotoxicity data; (2) develop a structured weight of evidence approach for assessing genotoxic/carcinogenic hazard; and (3) re-examine in vitro and in vivo correlations qualitatively and quantitatively. Conclusions from the workshop highlighted a willingness of scientists from various sectors to change and improve the current paradigm and move from a hazard identification approach to a “realistic” risk-based approach that incorporates information on mechanism of action, kinetics, and human exposure.. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Paper chemicals
KW - Risk assessment
KW - Chemical terrorism
KW - Specifications
KW - Carcinogenesis
KW - Genotoxicity
KW - In vitro assays
KW - Workshop report
N1 - Accession Number: 26250325; Thybaud, Véronique 1; Aardema, Marilyn 2; Casciano, Daniel 3; Dellarco, Vicki 4; Embry, Michelle R. 5; Email Address: membry@hesiglobal.org; Gollapudi, B. Bhaskar 6; Hayashi, Makoto 7; Holsapple, Michael P. 5; Jacobson-Kram, David 8; Kasper, Peter 9; MacGregor, James T. 10; Rees, Robert 11; Affiliations: 1: Drug Safety Evaluation, sanofi-aventis, 94400 Vitry sur Seine, France; 2: Procter & Gamble Co., Miami Valley Innovation Center, 11810 East Miami River Road, Cincinnati, OH 45239-8707, USA; 3: Dan Casciano & Associates, 47 Marcella Dr., Little Rock, AR 72223, USA; 4: Office of Pesticide Programs, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., N.W., Washington, DC 20460, USA; 5: ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, Ninth Floor, Washington, DC 20005-5802, USA; 6: Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Building 1803, Washington Street, Midland, MI 48642, USA; 7: Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-81-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan; 8: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA; 9: Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, D-53175 Bonn, Germany; 10: Toxicology Consulting Services, 201 Nomini Drive, Arnold, MD 21012, USA; 11: Genetic Toxicology, GlaxoSmithKline, Park Road, Ware Herts SG12 0DP, UK; Issue Info: Oct2007, Vol. 633 Issue 2, p67; Thesaurus Term: Paper chemicals; Thesaurus Term: Risk assessment; Thesaurus Term: Chemical terrorism; Subject Term: Specifications; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: In vitro assays; Author-Supplied Keyword: Workshop report; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.mrgentox.2007.05.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26250325&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105847975
T1 - Malathion exposure and the incidence of cancer in the agricultural health study.
AU - Bonner MR
AU - Coble J
AU - Blair A
AU - Beane Freeman LE
AU - Hoppin JA
AU - Sandler DP
AU - Alavanja MC
Y1 - 2007/10/09/
N1 - Accession Number: 105847975. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Insecticides -- Adverse Effects
KW - Malathion -- Adverse Effects
KW - Neoplasms -- Epidemiology
KW - Occupational Diseases -- Epidemiology
KW - Occupational Exposure -- Adverse Effects
KW - Adult
KW - Agriculture
KW - Confidence Intervals
KW - Female
KW - Incidence
KW - International Classification of Diseases
KW - Iowa
KW - Male
KW - Middle Age
KW - Neoplasms -- Chemically Induced
KW - North Carolina
KW - Occupational Diseases
KW - Odds Ratio
KW - Prospective Studies
KW - Questionnaires
KW - Human
SP - 1023
EP - 1034
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 166
IS - 9
PB - Oxford University Press / USA
AB - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance.
SN - 0002-9262
AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD.
U2 - PMID: 17720683.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105847975&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Silveira, I.A.F.B.
AU - Bastos, R.C.
AU - Neto, M.S.
AU - Laranjeira, A.P.
AU - Assis, E.F.
AU - Fernandes, S.A.R.
AU - Leal, M.L.
AU - Silva, W.C.
AU - Lee, C.-H.
AU - Frasch, C.E.
AU - Peralta, J.M.
AU - Jessouroun, E.
T1 - Characterization and immunogenicity of meningococcal group C conjugate vaccine prepared using hydrazide-activated tetanus toxoid
JO - Vaccine
JF - Vaccine
Y1 - 2007/10/10/
VL - 25
IS - 41
M3 - Article
SP - 7261
EP - 7270
SN - 0264410X
AB - Abstract: The steps to produce, purify and control an immunogenic Brazilian conjugate vaccine against group C meningococcus (MenCPS–TT) using hydrazide-activated tetanus toxoid were developed. The conjugation methodology reduced the reaction time easily allowing scale-up. One freeze-dried pilot vaccine lot purified by tangential filtration, showed satisfactory quality control results including safety and stability. The pilot vaccine was immunogenic in mice in a dose-dependent fashion generating a 10–20-fold rise in IgG response in mice. The vaccine also induced high bactericidal titers. Vaccine concentrations of 1 and 0.1μg showed higher avidity indices, suggesting induction of immunologic memory. These results support initiation of Phase I clinical studies with the MenCPS–TT conjugate vaccine. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryobiology
KW - Preventive medicine
KW - Clostridium diseases
KW - Immunoglobulin G
KW - Conjugate vaccine
KW - High avidity IgG
KW - Meningococcal group C
KW - Reductive amination
KW - Serum bactericidal activity
N1 - Accession Number: 26842339; Silveira, I.A.F.B. 1; Email Address: ivna@bio.fiocruz.br; Bastos, R.C. 1; Neto, M.S. 1; Laranjeira, A.P. 1; Assis, E.F. 1; Fernandes, S.A.R. 1; Leal, M.L. 1; Silva, W.C. 1; Lee, C.-H. 2; Frasch, C.E. 2; Peralta, J.M. 3; Jessouroun, E. 1; Affiliations: 1: Laboratório de Tecnologia Bacteriana, Bio-Manguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; 2: Center for Biologics Evaluation and Research (CBER), FDA, Bethesda, MD, USA; 3: Departamento de Imunologia, Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Issue Info: Oct2007, Vol. 25 Issue 41, p7261; Thesaurus Term: Cryobiology; Subject Term: Preventive medicine; Subject Term: Clostridium diseases; Subject Term: Immunoglobulin G; Author-Supplied Keyword: Conjugate vaccine; Author-Supplied Keyword: High avidity IgG; Author-Supplied Keyword: Meningococcal group C; Author-Supplied Keyword: Reductive amination; Author-Supplied Keyword: Serum bactericidal activity; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.07.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26842339&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yun, Hwi-yeol
AU - Lee, Seo-pan
AU - Jeong, Hae Hum
AU - Yoon, Young-ran
AU - Sohn, Soo Jung
AU - Kim, Sang Kyum
AU - Kang, Wonku
AU - Kwon, Kwang-il
T1 - Determination of afloqualone in human plasma using liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic studies in humans
JO - Talanta
JF - Talanta
Y1 - 2007/10/15/
VL - 73
IS - 4
M3 - Article
SP - 635
EP - 643
SN - 00399140
AB - Abstract: Two methods for determining the central-acting muscle relaxant afloqualone in human plasma were developed and compared using API2000 and API4000 liquid chromatography tandem mass spectrometry (LC/MS/MS) systems. In the API2000 LC/MS/MS system, afloqualone and the internal standard methaqualone were extracted from plasma using a methyl-tertiary ether. After drying the organic layer, the residue was reconstituted in a mobile phase (0.1% formic acid–acetonitrile:0.1% formic acid buffer, 80:20 v/v) and injected onto a reversed-phase C18 column. The isocratic mobile phase was eluted at 0.2ml/min. The ion transitions monitored in multiple reaction-monitoring mode were m/z 284→146 and 251→117 for afloqualone and methaqualone, respectively. Sample preparation for the API4000LC/MS/MS system involved simple protein precipitation with an organic mixture (methanol:10% ZnSO4 =8:2). The ion transitions monitored in multiple reaction-monitoring mode were m/z 284→146 and 251→131 for afloqualone and methaqualone, respectively. In both assays, the coefficient of variation of the precision was less than 11.8%, the accuracy exceeded 91.5%, the limit of quantification was 0.5ng/ml, and the limit of detection was 0.1ng/ml for afloqualone. Two methods were used to measure the plasma afloqualone concentration in healthy subjects after a single oral 20-mg dose of afloqualone. During subsequent application of the methods, we observed that high-concentration plasma samples (>7ng/ml) prepared using the protein precipitation method resulted in about 20% higher afloqualone concentrations than with plasma samples prepared using the liquid–liquid extraction method. We believe that this phenomenon was related to the cleanness of the sample and its chemical nature. [Copyright &y& Elsevier]
AB - Copyright of Talanta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - LIQUID chromatography
KW - MASS spectrometry
KW - SPECTRUM analysis
KW - Afloqualone
KW - API2000
KW - API4000
KW - LC/MS/MS
KW - Matrix effect
KW - Pharmacokinetic
N1 - Accession Number: 26570169; Yun, Hwi-yeol 1 Lee, Seo-pan 1 Jeong, Hae Hum 2 Yoon, Young-ran 3 Sohn, Soo Jung 4 Kim, Sang Kyum 1 Kang, Wonku 2 Kwon, Kwang-il 1; Email Address: kwon@cnu.ac.kr; Affiliation: 1: College of Pharmacy, Chungnam National University, Daejeon, Korea 2: College of Pharmacy, Catholic University of Daegu, Kyungbuk, Korea 3: Clinical Trial Center, Kyungpook National University Hospital, Daegu, Korea 4: Division of Bioequivalence, Korea Food and Drug Administration, Seoul, Korea; Source Info: Oct2007, Vol. 73 Issue 4, p635; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: SPECTRUM analysis; Author-Supplied Keyword: Afloqualone; Author-Supplied Keyword: API2000; Author-Supplied Keyword: API4000; Author-Supplied Keyword: LC/MS/MS; Author-Supplied Keyword: Matrix effect; Author-Supplied Keyword: Pharmacokinetic; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.talanta.2007.04.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Won, Se-Ra
AU - Hong, Mi-Jung
AU - Kim, Yong-Mu
AU - Li, Chun Ying
AU - Kim, Jang-Won
AU - Rhee, Hae-Ik
T1 - Oleic acid: An efficient inhibitor of glucosyltransferase
JO - FEBS Letters
JF - FEBS Letters
Y1 - 2007/10/16/
VL - 581
IS - 25
M3 - Article
SP - 4999
EP - 5002
SN - 00145793
AB - Abstract: Among the extracts from 420 kinds of herbs, Prunus salicina, showing the highest glucosyltransferase inhibition activity, was purified and designated GTI-0163. Structural determination of GTI-0163 revealed it to be an oleic acid-based unsaturated fatty acid. GTI-0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity. [Copyright &y& Elsevier]
AB - Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLEIC acid
KW - GLYCOSYLTRANSFERASES
KW - CHEMICAL inhibitors
KW - FATTY acids
KW - Dental caries
KW - GTase inhibitor
KW - Oleic acid
KW - Prunus salicina
N1 - Accession Number: 27000037; Won, Se-Ra 1 Hong, Mi-Jung 2 Kim, Yong-Mu 3 Li, Chun Ying 1 Kim, Jang-Won 1 Rhee, Hae-Ik 1,4; Email Address: rheehae@kangwon.ac.kr; Affiliation: 1: Division of Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea 2: S&D Co. Ltd., Chuncheon 200-160, Republic of Korea 3: Busan Regional Food and Drug Administration, KFDA 608-829, Republic of Korea 4: Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, South Korea; Source Info: Oct2007, Vol. 581 Issue 25, p4999; Subject Term: OLEIC acid; Subject Term: GLYCOSYLTRANSFERASES; Subject Term: CHEMICAL inhibitors; Subject Term: FATTY acids; Author-Supplied Keyword: Dental caries; Author-Supplied Keyword: GTase inhibitor; Author-Supplied Keyword: Oleic acid; Author-Supplied Keyword: Prunus salicina; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.febslet.2007.09.045
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27000037&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Menzies, Rob
AU - McIntyre, Peter
AU - Reid, Ray
AU - O’Brien, Katherine
AU - Santosham, Mathu
AU - Watt, James
AU - Angeles, Geoffrey
AU - Brown, Alex
AU - Dunbar, Melissa
AU - Leach, Amanda
AU - Crengle, Sue
AU - Lennon, Diana
AU - Mason, Henare
AU - Grim, Charles
AU - Nolan, Leo
AU - Smith, Phil
AU - Dumaresq, Gina
AU - Richardson, Ruth
AU - Moberley, Sarah
AU - Stirling, Janelle
T1 - Vaccine preventable diseases in indigenous populations—International perspectives: Satellite Symposium of the 5th International Symposium on Pneumococci and Pneumococcal Diseases, April 2006, Alice Springs, Australia
JO - Vaccine
JF - Vaccine
Y1 - 2007/10/16/
VL - 25
IS - 42
M3 - Proceeding
SP - 7281
EP - 7284
SN - 0264410X
KW - American native continental ancestry group
KW - Immunization
KW - Oceanic ancestry group
KW - Vaccine preventable diseases
N1 - Accession Number: 26842386; Menzies, Rob; Email Address: robertm3@chw.edu.au; McIntyre, Peter 1; Reid, Ray 2; O’Brien, Katherine 2; Santosham, Mathu 2; Watt, James 2; Angeles, Geoffrey 3; Brown, Alex 3; Dunbar, Melissa 3; Leach, Amanda 3; Crengle, Sue 4; Lennon, Diana 4; Mason, Henare 4; Grim, Charles 5; Nolan, Leo 5; Smith, Phil 5; Dumaresq, Gina 6; Richardson, Ruth 6; Moberley, Sarah 7; Stirling, Janelle 8; Affiliations: 1: National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia; 2: Johns Hopkins Centre for American Indian Health, School of Hygiene and Public Health, Johns Hopkins University, 624 North Broadway, Baltimore 21205, MD, USA; 3: Menzies School of Health Research, P.O. Box 41096, Casuarina, Northern Territory 0811, Australia; 4: University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand; 5: Indian Health Service, 801 Thompson Avenue Suite 440, Rockville, MD 20852, USA; 6: First Nations and Inuit Health Branch, Public Health Agency of Canada, 130 Colonnade Road, A.L. 6501H, Ottawa, Ontario K1A 0K9, Canada; 7: Department of Paedatrics, The University of Melbourne, Victoria 3010, Australia; 8: Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia; Issue Info: Oct2007, Vol. 25 Issue 42, p7281; Author-Supplied Keyword: American native continental ancestry group; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Oceanic ancestry group; Author-Supplied Keyword: Vaccine preventable diseases; Number of Pages: 4p; Document Type: Proceeding
L3 - 10.1016/j.vaccine.2007.08.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=26842386&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jiang, Shisong
AU - Rasmussen, Robert A.
AU - Nolan, Katrina M.
AU - Frankel, Fred R.
AU - Lieberman, Judy
AU - McClure, Harold M.
AU - Williams, Kristina M.
AU - Babu, Uma S.
AU - Raybourne, Richard B.
AU - Strobert, Elizabeth
AU - Ruprecht, Ruth M.
T1 - Live attenuated Listeria monocytogenes expressing HIV Gag: Immunogenicity in rhesus monkeys
JO - Vaccine
JF - Vaccine
Y1 - 2007/10/16/
VL - 25
IS - 42
M3 - Article
SP - 7470
EP - 7479
SN - 0264410X
AB - Abstract: Induction of strong cellular immunity will be important for AIDS vaccine candidates. Natural infection with wild-type Listeria monocytogenes (Lm), an orally transmitted organism, is known to generate strong cellular immunity, thus raising the possibility that live attenuated Lm could serve as a vaccine vector. We sought to examine the potential of live attenuated Lm to induce cellular immune responses to HIV Gag. Rhesus macaques were immunized with Lmdd-gag that expresses HIV gag and lacks two genes in the d-alanine (d-ala) synthesis pathway. Without this key component of the bacterial cell wall, vaccine vector replication critically depends on exogenous d-ala. Lmdd-gag was given to animals either solely orally or by oral priming followed by intramuscular (i.m.) boosting; d-ala was co-administered with all vaccinations. Lmdd-gag and d-ala were well tolerated. Oral priming/oral boosting induced Gag-specific cellular immune responses, whereas oral priming/i.m. boosting induced systemic as well as mucosal anti-Gag antibodies. These results suggest that the route of vaccination may bias anti-Gag immune responses either towards T-helper type 1 (Th1) or Th2 responses; overall, our data show that live attenuated, recombinant Lmdd-gag is safe and immunogenic in primates. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Listeria
KW - Immunity
KW - Agglutination
KW - Antigens
KW - Cellular immunity
KW - d-alanine
KW - Listeria monocytogenes
KW - Rhesus monkey
KW - Vaccine
N1 - Accession Number: 26842462; Jiang, Shisong 1,2; Rasmussen, Robert A. 1,2; Nolan, Katrina M. 3; Frankel, Fred R. 3; Lieberman, Judy 4,5; McClure, Harold M. 6; Williams, Kristina M. 7; Babu, Uma S. 7; Raybourne, Richard B. 7; Strobert, Elizabeth 6; Ruprecht, Ruth M. 1,2; Email Address: ruth_ruprecht@dfci.harvard.edu; Affiliations: 1: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, United States; 2: Department of Medicine, Harvard Medical School, Boston, MA 02115, United States; 3: Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, United States; 4: CBR Institute for Biomedical Research, Boston, MA 02115, United States; 5: Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States; 6: Division of Research Resources and Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States; 7: Immunobiology Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, United States; Issue Info: Oct2007, Vol. 25 Issue 42, p7470; Thesaurus Term: Listeria; Thesaurus Term: Immunity; Thesaurus Term: Agglutination; Thesaurus Term: Antigens; Author-Supplied Keyword: Cellular immunity; Author-Supplied Keyword: d-alanine; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: Rhesus monkey; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.08.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bidol, S.A.
AU - Daly, E.R.
AU - Rickert, R.E.
AU - Newport, S.
AU - Braenderup, S.
AU - Typhimurium, S.
AU - Hill, T.A.
AU - Al Khaldi, S.
AU - Taylor Jr., T.H,
AU - Lynch, M.F.
AU - Painter, J.A.
AU - Braden, C.R.
AU - Yu, P.A.
AU - Demma, L.
AU - Behravesh, C. Barton
AU - Olson, C.K.
AU - Greene, S.K.
AU - Schmitz, A.M.
AU - Blaney, D.D.
AU - Gershman, M.
T1 - Multistate Outbreaks of Salmonella Infections Associated With Raw Tomatoes Eaten in Restaurants--United States, 2005-2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/10/17/
VL - 298
IS - 15
M3 - Article
SP - 1753
EP - 1755
SN - 00987484
AB - This article presents news from the U.S. Centers for Disease Control and Prevention (CDC). This study looked at Salmonella infection outbreaks in the United States due to raw tomato consumption at restaurants in 2005-2006. There were four large outbreaks in the time period that resulted in 459 confirmed cases in 21 states. Investigation by the CDC determined that the tomatoes had been shipped from fields in Florida, Ohio and Virginia and says that these outbreaks show the need to research policies that will prevent Salmonella contamination early in the production and packing process.
KW - SALMONELLA diseases
KW - SALMONELLA food poisoning
KW - FOOD pathogens
KW - ENTEROBACTERIACEAE
KW - TOMATOES
KW - FOOD contamination -- Research
KW - FRUIT -- Contamination
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 27070528; Bidol, S.A. 1 Daly, E.R. 2 Rickert, R.E. 3 Newport, S. 4 Braenderup, S. 4,5 Typhimurium, S. 6 Hill, T.A. 7 Al Khaldi, S. 7 Taylor Jr., T.H, 8 Lynch, M.F. 9 Painter, J.A. 9 Braden, C.R. 9 Yu, P.A. 9 Demma, L. 9 Behravesh, C. Barton 10 Olson, C.K. 10 Greene, S.K. 10 Schmitz, A.M. 10 Blaney, D.D. 10 Gershman, M. 10; Affiliation: 1: Michigan Department of Community Health 2: New Hampshire Department of Heatlh and Human Services 3: Pennsylvania Department of Health 4: Investigation Team 2005 5: Investigation Team 2006 6: Investigation Team 2006, Pulsenet. 7: Food and Drug Administration 8: Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases 9: Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases 10: EIS officers, CDC; Source Info: 10/17/2007, Vol. 298 Issue 15, p1753; Subject Term: SALMONELLA diseases; Subject Term: SALMONELLA food poisoning; Subject Term: FOOD pathogens; Subject Term: ENTEROBACTERIACEAE; Subject Term: TOMATOES; Subject Term: FOOD contamination -- Research; Subject Term: FRUIT -- Contamination; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Gray, Darryl T.
AU - Hollingworth, William
AU - Onwudiwe, Nneka
AU - Deyo, Richard A.
AU - Jarvik, Jeffrey G.
T1 - Thoracic and Lumbar Vertebroplasties Performed in US Medicare Enrollees, 2001-2005.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/10/17/
VL - 298
IS - 15
M3 - Letter
SP - 1760
EP - 1762
SN - 00987484
AB - A research letter to the editor is presented on thoracic and lumbar vertebroplasties procedures performed on U.S. Medicare patients from 2001-2005.
KW - LETTERS to the editor
KW - FRACTURES -- Treatment
N1 - Accession Number: 27070545; Gray, Darryl T. 1; Email Address: darryl.gray@ahrq.hhs.gov Hollingworth, William 2 Onwudiwe, Nneka 3 Deyo, Richard A. 4 Jarvik, Jeffrey G. 5; Affiliation: 1: Center for Quality Improvement and Patient Safety Agency for Healthcare Research and Quality Rockville, Maryland 2: Department of Social Medicine, University of Bristol Bristol, England 3: Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore 4: Department of Medicine University of Washington Seattle 5: Department of Radiology University of Washington Seattle; Source Info: 10/17/2007, Vol. 298 Issue 15, p1760; Subject Term: LETTERS to the editor; Subject Term: FRACTURES -- Treatment; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mulhern, Barbara
AU - Amandus, Harlan
AU - Hartley, Daniel
T1 - A History of Violence.
JO - Convenience Store News
JF - Convenience Store News
Y1 - 2007/10/22/
VL - 43
IS - 13
M3 - Article
SP - 151
EP - 156
PB - Stagnito Media
SN - 01948733
AB - The article focuses on the strategies suggested by the U.S. National Institute for Occupational Safety & Health and Occupational Safety and Health Administration to prevent workplace violence at convenience stores. Some of the strategies include training employees not to resist during a robbery, using locked drop safes, making high-risk areas visible to more people and installing good internal and external lighting.
KW - VIOLENCE in the workplace -- Prevention
KW - EMPLOYEE training
KW - CONVENIENCE stores
KW - SECURITY measures
KW - UNITED States
KW - UNITED States. Occupational Safety & Health Administration
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 27343054; Mulhern, Barbara; Amandus, Harlan 1; Hartley, Daniel 2; Affiliations: 1: Analysis and field evaluations branch chief with the National Institute for Occupational Safety and Health; 2: workplace violence prevention coordinator with the National institute for Occupational Safety and Health.; Issue Info: 10/22/2007, Vol. 43 Issue 13, p151; Thesaurus Term: VIOLENCE in the workplace -- Prevention; Thesaurus Term: EMPLOYEE training; Thesaurus Term: CONVENIENCE stores; Subject Term: SECURITY measures; Subject: UNITED States ; Company/Entity: UNITED States. Occupational Safety & Health Administration ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 445120 Convenience Stores; NAICS/Industry Codes: 611430 Professional and Management Development Training; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 4p; Illustrations: 4 Color Photographs, 1 Chart; Document Type: Article; Full Text Word Count: 2146
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hierro, Aitor
AU - Rojas, Adriana L.
AU - Rojas, Raul
AU - Murthy, Namita
AU - Effantin, Grégory
AU - Kajava, Andrey V.
AU - Steven, Alasdair C.
AU - Bonifacino, Juan S.
AU - Hurley, James H.
T1 - Functional architecture of the retromer cargo-recognition complex.
JO - Nature
JF - Nature
Y1 - 2007/10/25/
VL - 449
IS - 7165
M3 - Article
SP - 1063
EP - 1067
PB - Nature Publishing Group
SN - 00280836
AB - The retromer complex is required for the sorting of acid hydrolases to lysosomes, transcytosis of the polymeric immunoglobulin receptor, Wnt gradient formation, iron transporter recycling and processing of the amyloid precursor protein. Human retromer consists of two smaller complexes: the cargo recognition VPS26–VPS29–VPS35 heterotrimer and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 (ref. 13). Here we report the crystal structure of a VPS29–VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 (refs 14, 15) acts as a scaffold for the carboxy-terminal half of VPS35. VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid, the concave face of which completely covers the metal-binding site of VPS29, whereas the convex face exposes a series of hydrophobic interhelical grooves. Electron microscopy shows that the intact VPS26–VPS29–VPS35 complex is a stick-shaped, flexible structure, approximately 21 nm long. A hybrid structural model derived from crystal structures, electron microscopy, interaction studies and bioinformatics shows that the α-solenoid fold extends the full length of VPS35, and that VPS26 is bound at the opposite end from VPS29. This extended structure presents multiple binding sites for the SNX complex and receptor cargo, and appears capable of flexing to conform to curved vesicular membranes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROLASES
KW - PROTEIN precursors
KW - ELECTRON microscopy
KW - PARTICLES (Nuclear physics)
KW - BIOINFORMATICS
KW - INFORMATION science
KW - COMPUTATIONAL biology
KW - BINDING sites (Biochemistry)
KW - BIOCHEMISTRY
N1 - Accession Number: 27191174; Hierro, Aitor 1 Rojas, Adriana L. 1 Rojas, Raul 2 Murthy, Namita 2 Effantin, Grégory 3 Kajava, Andrey V. 4 Steven, Alasdair C. 3 Bonifacino, Juan S. 2 Hurley, James H. 1; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and KidneyDiseases 2: Cell Biology and Metabolism Branch,National Institute of Child Health and Human Development 3: Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA 4: Centre de Recherches de Biochimie Macromoléculaire, CNRS, University of Montpellier, 1919 Route deMende, 34293 Montpellier, France; Source Info: 10/25/2007, Vol. 449 Issue 7165, p1063; Subject Term: HYDROLASES; Subject Term: PROTEIN precursors; Subject Term: ELECTRON microscopy; Subject Term: PARTICLES (Nuclear physics); Subject Term: BIOINFORMATICS; Subject Term: INFORMATION science; Subject Term: COMPUTATIONAL biology; Subject Term: BINDING sites (Biochemistry); Subject Term: BIOCHEMISTRY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Illustrations: 2 Color Photographs, 2 Diagrams; Document Type: Article
L3 - 10.1038/nature06216
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27191174&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martella, Vito
AU - Bányai, Krisztián
AU - Lorusso, Eleonora
AU - Decaro, Nicola
AU - Bellacicco, Anna
AU - Desario, Costantina
AU - Corrente, Marialaura
AU - Greco, Grazia
AU - Moschidou, Paschalina
AU - Tempesta, Maria
AU - Arista, Serenella
AU - Ciarlet, Max
AU - Lavazza, Antonio
AU - Buonavoglia, Canio
T1 - Genetic heterogeneity in the VP7 of group C rotaviruses
JO - Virology
JF - Virology
Y1 - 2007/10/25/
VL - 367
IS - 2
M3 - Article
SP - 358
EP - 366
SN - 00426822
AB - Abstract: Evidence for a possible zoonotic role of group C rotaviruses (GCRVs) has been recently provided. To gain information on the genetic relationships between human and animal GCRVs, we sequenced the VP7 gene of 10 porcine strains detected during a large surveillance study from different outbreaks of gastroenteritis in piglets. Four GCRV strains were genetically related to the prototype GCRV porcine Cowden strain. A completely new VP7 genotype included 4 strains (344/04-7-like) that shared 92.5% to 97.0% aa identity to each other, but <83% to human GCRVs and <79% to other porcine and bovine GCRVs. A unique 4-aa insertion (SSSV or SSTI), within a variable region at the carboxy-terminus of VP7, represented a distinctive feature for these 4 unique strains. An additional strain, 134/04-18, was clearly different from all human and animal GCRVs (<85% aa identity) and likely accounts for a distinct VP7 genotype. The VP7 of a unique strain, 42/05-21, shared similar ranges of aa sequence identities with porcine and human strains (88.0–90.7% to porcine GCRVs and 85.2–88.2% to human GCRVs). Plotting the VP7 gene of strain 42/05-21 against the VP7 of human and porcine strains revealed discontinuous evolution rates throughout the VP7 molecule, suggesting different mutational pressure or a remote intragenic recombination event. These findings provide the need for future epidemiological surveys and warrant studies to investigate the pathogenic potential of these novel GCRVs in pigs. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - ZOONOSES
KW - HUMAN-animal relationships
KW - GENETIC regulation
KW - Enteritis
KW - Group C rotavirus
KW - Pigs
KW - Zoonosis
N1 - Accession Number: 26992061; Martella, Vito 1; Email Address: v.martella@veterinaria.uniba.it Bányai, Krisztián 2 Lorusso, Eleonora 1 Decaro, Nicola 1 Bellacicco, Anna 1 Desario, Costantina 1 Corrente, Marialaura 1 Greco, Grazia 1 Moschidou, Paschalina 1 Tempesta, Maria 1 Arista, Serenella 3 Ciarlet, Max 4 Lavazza, Antonio 5 Buonavoglia, Canio 1; Affiliation: 1: Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine of Bari, Valenzano, Bari, Italy 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 3: Department of Hygiene and Microbiology, University of Palermo, Palermo, Italy 4: Vaccine Biologics, Clinical Research, Merck Research Laboratories, North Wales, PA, USA 5: Istituto Zooprofilattico Sperimentale di Lombardia/Emilia Romagna, Brescia, Italy; Source Info: Oct2007, Vol. 367 Issue 2, p358; Subject Term: ROTAVIRUSES; Subject Term: ZOONOSES; Subject Term: HUMAN-animal relationships; Subject Term: GENETIC regulation; Author-Supplied Keyword: Enteritis; Author-Supplied Keyword: Group C rotavirus; Author-Supplied Keyword: Pigs; Author-Supplied Keyword: Zoonosis; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2007.05.039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26992061&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhou, Hong Yu
AU - Shin, Eun Myung
AU - Guo, Lian Yu
AU - Zou, Li Bo
AU - Xu, Guang Hua
AU - Lee, Seung-Ho
AU - Ze, Keum Ryon
AU - Kim, Eun-Kyung
AU - Kang, Sam Sik
AU - Kim, Yeong Shik
T1 - Anti-inflammatory activity of 21(α, β)-methylmelianodiols, novel compounds from Poncirus trifoliata Rafinesque
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2007/10/31/
VL - 572
IS - 2/3
M3 - Article
SP - 239
EP - 248
SN - 00142999
AB - Abstract: The fruits of Poncirus trifoliata (L.) are widely used in Oriental medicine as a remedy for allergic inflammation. As a part of our program to screen medicinal plants for potential anti-inflammatory compounds, 21α-methylmelianodiol (21α-MMD) and 21β-methylmelianodiol (21β-MMD), which are two isomers of 21-methylmelianodiol isolated from the fruits of P. trifoliata for the first time, were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. 21α-MMD and 21β-MMD attenuated LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein expressions as well as the mRNA levels of iNOS, COX-2, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). To investigate the mechanism involved, we examined the effect of 21α-MMD and 21β-MMD on LPS-induced nuclear factor-κB (NF-κB) activation. Both 21α-MMD and 21β-MMD significantly inhibited LPS-induced NF-κB transcriptional activity in RAW 264.7 macrophages. Moreover, the in vivo anti-inflammatory effect of 21α-MMD was examined in two mouse models of acute inflammation. In the carrageenan-induced paw edema model, administration of 21α-MMD (20 and 100 mg/kg, i.p.) dose-dependently reduced paw swelling. In addition, 21α-MMD significantly inhibited the dye leakage in an acetic acid-induced vascular permeability assay. Taken together, our data indicate that 21-methylmelianodiol is an important constituent of the fruit of P. trifoliata, and that the inhibition of iNOS and COX-2 expression by 21α-MMD and 21β-MMD might be one of the mechanisms responsible for their anti-inflammatory effects. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-inflammatory agents
KW - NITROGEN compounds
KW - MEDICAL botany
KW - ACETIC acid
KW - β)-methylmelianodiols ( 21(α )
KW - Anti-inflammation
KW - Cyclooxygenase-2
KW - In vivo activity
KW - Inducible nitric oxide synthase
KW - Nuclear factor-κB
N1 - Accession Number: 26681451; Zhou, Hong Yu 1,2 Shin, Eun Myung 1 Guo, Lian Yu 1 Zou, Li Bo 2 Xu, Guang Hua 3 Lee, Seung-Ho 3 Ze, Keum Ryon 4 Kim, Eun-Kyung 4 Kang, Sam Sik 1 Kim, Yeong Shik 1; Email Address: kims@snu.ac.kr; Affiliation: 1: Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yeonkun-Dong, Jongno-Ku Seoul 110-460, South Korea 2: Department of Pharmacology, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China 3: College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea 4: Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Oct2007, Vol. 572 Issue 2/3, p239; Subject Term: ANTI-inflammatory agents; Subject Term: NITROGEN compounds; Subject Term: MEDICAL botany; Subject Term: ACETIC acid; Author-Supplied Keyword: β)-methylmelianodiols ( 21(α ); Author-Supplied Keyword: Anti-inflammation; Author-Supplied Keyword: Cyclooxygenase-2; Author-Supplied Keyword: In vivo activity; Author-Supplied Keyword: Inducible nitric oxide synthase; Author-Supplied Keyword: Nuclear factor-κB; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ejphar.2007.07.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26681451&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Donald
AU - Gwiazda, Roberto
AU - Bowler, Rosemarie
AU - Roels, Harry
AU - Park, Robert
AU - Taicher, Christopher
AU - Lucchini, Roberto
T1 - Biomarkers of Mn Exposure in Humans.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/11//
VL - 50
IS - 11
M3 - Article
SP - 801
EP - 811
SN - 02713586
AB - The article presents a case study on the implication of the biomarkers of manganese (Mn) exposure in humans. Several body fluids including whole blood, plasma and urine with Mn levels showed exposure in occupationally exposed humans. The Mn level in the blood samples of active ferroalloy workers was linked with total air Mn levels in subjects exposed to low and moderate air Mn levels, and blood Mn in bridge welders were linked with their cumulative respiratory exposure index. A complex and limited relationship is evident between exposure and blood Mn levels that may depend on exposure attributes and on the fact that the latency of blood sampling is relative to exposure. Plasma and urine Mn appear to be of little use as exposure biomarkers.
KW - Biochemical markers
KW - Industrial safety
KW - Manganese -- Physiological effect
KW - Blood plasma
KW - Urine
KW - Industrial workers
KW - Body fluids
KW - Pulmonary function tests
KW - Fluid mechanics
KW - biomarkers
KW - blood
KW - blood cells
KW - manganese
KW - plasma
N1 - Accession Number: 27589220; Smith, Donald 1; Email Address: smith@etox.ucsc.edu; Gwiazda, Roberto 1; Bowler, Rosemarie 2; Roels, Harry 3; Park, Robert 4; Taicher, Christopher 1; Lucchini, Roberto 5; Affiliations: 1: Environmental Toxicology, University of California, Santa Cruz, California; 2: San Francisco State University, San Francisco, California; 3: Industrial Toxicology and Occupational Medicine Unit, School of Public Health, Université catholique de Louvain, Brussels, Belgium; 4: National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 5: Institute of Occupational Health, University of Brescia, Brescia, Italy; Issue Info: Nov2007, Vol. 50 Issue 11, p801; Thesaurus Term: Biochemical markers; Thesaurus Term: Industrial safety; Subject Term: Manganese -- Physiological effect; Subject Term: Blood plasma; Subject Term: Urine; Subject Term: Industrial workers; Subject Term: Body fluids; Subject Term: Pulmonary function tests; Subject Term: Fluid mechanics; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: blood; Author-Supplied Keyword: blood cells; Author-Supplied Keyword: manganese; Author-Supplied Keyword: plasma; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 12p; Illustrations: 7 Charts, 4 Graphs; Document Type: Article
L3 - 10.1002/ajim.20506
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27589220&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105939059
T1 - AHRQ commentary. Evidence-based practice: AHRQ's role in generating and disseminating knowledge.
AU - Coopey M
AU - Nix MP
AU - Clancy CM
Y1 - 2007/11//
N1 - Accession Number: 105939059. Language: English. Entry Date: 20080125. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Perioperative Care. NLM UID: 0372403.
KW - Professional Practice, Evidence-Based
KW - United States Agency for Healthcare Research and Quality
KW - Knowledge
KW - Nursing Practice, Evidence-Based
KW - Practice Guidelines
KW - Quality of Health Care
KW - Research, Nursing
KW - Systematic Review
SP - 857
EP - 860
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 86
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Senior Health Policy Analyst, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 17998005.
DO - 10.1016/j.aorn.2007.10.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105939059&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hyesuk Kong
AU - Volokhov, Dmitriy V.
AU - George, Joseph
AU - Ikonomi, Pranvera
AU - Chandler, Donna
AU - Anderson, Christine
AU - Chizhikov, Vladimir
T1 - Application of cell culture enrichment for improving the sensitivity of mycoplasma detection methods based on nucleic acid amplification technology (NAT).
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2007/11//
VL - 77
IS - 1
M3 - Article
SP - 223
EP - 232
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Herein, we present data demonstrating that the application of initial cell culture enrichment could significantly improve mycoplasma testing methods based on the nucleic acid amplification technology (NAT) including a polymerase chain reaction (PCR)/microarray method. The results of the study using Vero cells demonstrated that this cell culture is able (1) to support efficient growth of mycoplasmas of primary interest, i.e., species found to be cell line contaminants, (2) to increase the sensitivity of NAT assay to the detection limits of the conventional broth/agar culture methods, and (3) to reduce the time required for mycoplasma testing fourfold in comparison with the conventional methods. Detection and identification of mycoplasmal agents were conducted using a modified PCR/microarray assay based on genetic differences among Mollicutes in the 16S-23S rRNA intergenic transcribed spacer (ITS). The application of nano-gold/silver enhancement technology instead of previously used fluorescent dyes significantly simplified the readout of microarray results and allowed us to avoid using expensive scanning equipment. This modification has the potential to expand the implementation of microarray techniques into laboratories involved in diagnostic testing of mycoplasma contamination in cell substrates and potentially in other biological and pharmaceutical products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL culture
KW - MYCOPLASMA
KW - NUCLEIC acids
KW - POLYMERASE chain reaction
KW - MYCOPLASMATACEAE
KW - CULTURES (Biology)
N1 - Accession Number: 27004205; Hyesuk Kong 1 Volokhov, Dmitriy V. 1; Email Address: dmitriy.volokhov@fda.hhs.gov George, Joseph 1 Ikonomi, Pranvera 2 Chandler, Donna 1 Anderson, Christine 1 Chizhikov, Vladimir 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, USA 2: American Type Culture Collection (ATCC), 10801 University Boulevard, Manassas, VA 20108, USA; Source Info: Nov2007, Vol. 77 Issue 1, p223; Subject Term: CELL culture; Subject Term: MYCOPLASMA; Subject Term: NUCLEIC acids; Subject Term: POLYMERASE chain reaction; Subject Term: MYCOPLASMATACEAE; Subject Term: CULTURES (Biology); Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1007/s00253-007-1135-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27004205&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105969330
T1 - Ask an expert column. So what? The challenge of doing 'need to know' versus 'would like to know' research.
AU - Hughes RG
AU - Clancy CM
Y1 - 2007/11//
N1 - Accession Number: 105969330. Language: English. Entry Date: 20080215. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 8901557.
KW - Information Needs
KW - Research, Nursing
KW - Health Services Research
KW - Nurse Researchers
KW - Research Priorities
KW - Research Subjects
KW - United States Agency for Healthcare Research and Quality
SP - 210
EP - 213
JO - Applied Nursing Research
JF - Applied Nursing Research
JA - APPL NURS RES
VL - 20
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0897-1897
AD - Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD; Ronda.Hughes@ahrq.hhs.gov
U2 - PMID: 17996809.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105969330&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moon, Hojin
AU - Ahn, Hongshik
AU - Kodell, Ralph L.
AU - Baek, Songjoon
AU - Lin, Chien-Ju
AU - Chen, James J.
T1 - Ensemble methods for classification of patients for personalized medicine with high-dimensional data
JO - Artificial Intelligence in Medicine
JF - Artificial Intelligence in Medicine
Y1 - 2007/11//
VL - 41
IS - 3
M3 - Article
SP - 197
EP - 207
SN - 09333657
AB - Summary: Objective: Personalized medicine is defined by the use of genomic signatures of patients in a target population for assignment of more effective therapies as well as better diagnosis and earlier interventions that might prevent or delay disease. An objective is to find a novel classification algorithm that can be used for prediction of response to therapy in order to help individualize clinical assignment of treatment. Methods and materials: Classification algorithms are required to be highly accurate for optimal treatment on each patient. Typically, there are numerous genomic and clinical variables over a relatively small number of patients, which presents challenges for most traditional classification algorithms to avoid over-fitting the data. We developed a robust classification algorithm for high-dimensional data based on ensembles of classifiers built from the optimal number of random partitions of the feature space. The software is available on request from the authors. Results: The proposed algorithm is applied to genomic data sets on lymphoma patients and lung cancer patients to distinguish disease subtypes for optimal treatment and to genomic data on breast cancer patients to identify patients most likely to benefit from adjuvant chemotherapy after surgery. The performance of the proposed algorithm is consistently ranked highly compared to the other classification algorithms. Conclusion: The statistical classification method for individualized treatment of diseases developed in this study is expected to play a critical role in developing safer and more effective therapies that replace one-size-fits-all drugs with treatments that focus on specific patient needs. [Copyright &y& Elsevier]
AB - Copyright of Artificial Intelligence in Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTIFICIAL intelligence -- Medical applications
KW - ALGORITHMS
KW - COMPUTERS in medicine
KW - SET theory
KW - CLASSIFICATION
KW - GENETIC software
KW - CANCER treatment
KW - Class prediction
KW - Cross-validation
KW - Ensembles
KW - Majority voting
KW - Risk profiling
N1 - Accession Number: 27354044; Moon, Hojin 1; Email Address: hmoon623@yahoo.com Ahn, Hongshik 2 Kodell, Ralph L. 3 Baek, Songjoon 4 Lin, Chien-Ju 4 Chen, James J. 4; Affiliation: 1: Department of Mathematics and Statistics, California State University-Long Beach, 1250 Bellflower Blvd., Long Beach, CA 90840, USA 2: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794-3600, USA 3: Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 4: Division of Biometry and Risk Assessment, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Nov2007, Vol. 41 Issue 3, p197; Subject Term: ARTIFICIAL intelligence -- Medical applications; Subject Term: ALGORITHMS; Subject Term: COMPUTERS in medicine; Subject Term: SET theory; Subject Term: CLASSIFICATION; Subject Term: GENETIC software; Subject Term: CANCER treatment; Author-Supplied Keyword: Class prediction; Author-Supplied Keyword: Cross-validation; Author-Supplied Keyword: Ensembles; Author-Supplied Keyword: Majority voting; Author-Supplied Keyword: Risk profiling; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.artmed.2007.07.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27354044&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Baitty, Robert L.
AU - Ashton, Robyn S.
AU - Gale, Randy C.
AU - Tims, Shelley E.
AU - Wabeke, Anita
AU - Burdick, James F.
T1 - 31: Update on the C.W. Bill Young Cell Transplantation Program & National Cord Blood Inventory
JO - Biology of Blood & Marrow Transplantation
JF - Biology of Blood & Marrow Transplantation
Y1 - 2007/11//
VL - 13
IS - 11
M3 - Abstract
SP - 1403
EP - 1404
SN - 10838791
N1 - Accession Number: 27161368; Baitty, Robert L. 1 Ashton, Robyn S. 1 Gale, Randy C. 1 Tims, Shelley E. 1 Wabeke, Anita 1 Burdick, James F. 1; Affiliation: 1: Department of Health and Human Services, Health Resources and Services Administration, Division of Transplantation, Rockville, MD; Source Info: Nov2007, Vol. 13 Issue 11, p1403; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.bbmt.2007.08.045
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27161368&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn M.
AU - Kiley, James P.
AU - Weiss, Kevin B.
T1 - Eliminating Asthma Disparities Through Multistakeholder Partnerships.
JO - CHEST
JF - CHEST
Y1 - 2007/11//
VL - 132
IS - 5
M3 - Article
SP - 1422
EP - 1424
SN - 00123692
AB - The article reports on the National Heart, Lung and Blood Institute's (NHLBI) commitment to reduce asthma disparities. In 2002, the institute funded four Centers for Reducing Asthma Disparities to accelerate research to understand why certain racial, ethnic and socioeconomic groups are severely affected by asthma. Meanwhile, its demonstration and education research program is supporting research to identify strategies that will extend the benefits of asthma management to diverse populations.
KW - ASTHMA -- Treatment
KW - LUNG diseases
KW - MEDICAL research
KW - UNITED States
KW - NATIONAL Heart Lung & Blood Institute
N1 - Accession Number: 27727472; Clancy, Carolyn M. 1 Kiley, James P. 2 Weiss, Kevin B. 3; Email Address: kevin.weiss@va.gov; Affiliation: 1: Agency for Healthcare Research and Quality Rockville, MD 2: National Institutes of Health Bethesda, MD 3: Northwestern University Feinberg School of Medicine Chicago, IL; Source Info: Nov2007, Vol. 132 Issue 5, p1422; Subject Term: ASTHMA -- Treatment; Subject Term: LUNG diseases; Subject Term: MEDICAL research; Subject Term: UNITED States; Company/Entity: NATIONAL Heart Lung & Blood Institute; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1378/chest.07-1947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27727472&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn M.
AU - Kiley, James P.
AU - Weiss, Kevin B.
T1 - Eliminating Asthma Disparities Through Multistakeholder Partnerships.
JO - CHEST
JF - CHEST
Y1 - 2007/11//
VL - 132
IS - 5
M3 - Article
SP - 1422
EP - 1424
SN - 00123692
AB - The article reports on the National Heart, Lung and Blood Institute's (NHLBI) commitment to reduce asthma disparities. In 2002, the institute funded four Centers for Reducing Asthma Disparities to accelerate research to understand why certain racial, ethnic and socioeconomic groups are severely affected by asthma. Meanwhile, its demonstration and education research program is supporting research to identify strategies that will extend the benefits of asthma management to diverse populations.
KW - NATIONAL Heart Lung & Blood Institute
KW - ASTHMA -- Treatment
KW - LUNG diseases
KW - MEDICAL research
KW - UNITED States
N1 - Accession Number: 27727472; Clancy, Carolyn M. 1; Kiley, James P. 2; Weiss, Kevin B. 3; Email Address: kevin.weiss@va.gov; Source Information: Nov2007, Vol. 132 Issue 5, p1422; Subject: NATIONAL Heart Lung & Blood Institute; Subject: ASTHMA -- Treatment; Subject: LUNG diseases; Subject: MEDICAL research; Geographic Terms: UNITED States; Number of Pages: 3p; Document Type: Article
L3 - 10.1378/chest.07-1947
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Hai-Ning Yu
AU - Sheng-Rong Shen
AU - Jun-Jie Yin
T1 - Effects of Metal Ions, Catechins, and Their Interactions on Prostate Cancer.
JO - Critical Reviews in Food Science & Nutrition
JF - Critical Reviews in Food Science & Nutrition
Y1 - 2007/11//
VL - 47
IS - 8
M3 - Article
SP - 711
EP - 719
SN - 10408398
AB - Prostate cancer is threatening human health heavily, for its causes are related to diet, genetic factors, and lifestyle. Metal ions, which are necessary to our health, are important factors inducing many diseases including prostate cancer in the condition of absence or excess. Epidemiological and laboratory studies provide convincing evidence that green tea prevents and cures prostate cancer. Practically, interactions of catechins, which are the main bioactive components in green tea or GTP, with metal ions have a new aspect to investigate their mechanism in preventing and curing prostate cancer. In the present paper, we summarize some research about the effects of catechins with metal ions related to prostate cancer and their interactions on prostate cancer. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METAL ions
KW - CATECHIN
KW - PROSTATE cancer
KW - DISEASES -- Risk factors
KW - DIET
KW - MEDICAL care
KW - GREEN tea
KW - BIOACTIVE compounds
KW - THERAPEUTIC use
KW - green tea
KW - metal ions
KW - prostate cancer
N1 - Accession Number: 27395072; Hai-Ning Yu 1 Sheng-Rong Shen 2; Email Address: shrshen@zju.edu.cn Jun-Jie Yin 3; Affiliation: 1: College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, P.R. China,School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, P.R. China 2: School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, P.R. China 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA; Source Info: Nov2007, Vol. 47 Issue 8, p711; Subject Term: METAL ions; Subject Term: CATECHIN; Subject Term: PROSTATE cancer; Subject Term: DISEASES -- Risk factors; Subject Term: DIET; Subject Term: MEDICAL care; Subject Term: GREEN tea; Subject Term: BIOACTIVE compounds; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: green tea; Author-Supplied Keyword: metal ions; Author-Supplied Keyword: prostate cancer; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/10408390600948873
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Patton, Nanette
AU - Shechet, Allan
T1 - Wisdom for Building the Project Manager/Project Sponsor Relationship: Partnership for Project Success.
JO - CrossTalk: The Journal of Defense Software Engineering
JF - CrossTalk: The Journal of Defense Software Engineering
Y1 - 2007/11//
VL - 20
IS - 11
M3 - Article
SP - 4
EP - 9
SN - 21601577
AB - The project sponsor can promote information technology (IT) project success in several ways, yet many projects either have no formally designated project sponsor or the project sponsor is confused about his/her role. The project sponsor's role traditionally includes project approval, funding, and staffing, but can include much more. The project sponsor is sometimes called the champion of the project or the key stakeholder of the project. Because the role of the project sponsor sometimes overlaps with the project manager's role, confusion can arise. This article discusses conventional roles and responsibilities of the project sponsor and then discusses strategies a project manager can employ to define boundaries to reduce role confusion and promote partnership to facilitate project success. [ABSTRACT FROM AUTHOR]
AB - Copyright of CrossTalk: The Journal of Defense Software Engineering is the property of USAF Software Technology Support Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROJECT management
KW - INFORMATION technology
KW - CAPITALISTS & financiers
KW - PARTNERSHIP (Business)
KW - BUSINESS enterprises
KW - STOCKHOLDERS
N1 - Accession Number: 27482871; Patton, Nanette 1; Email Address: nanette.patton@us.army.mil Shechet, Allan 2; Email Address: allan@savvyservices.net; Affiliation: 1: Office of the Surgeon General 2: Savvy Services Incorporated; Source Info: Nov2007, Vol. 20 Issue 11, p4; Subject Term: PROJECT management; Subject Term: INFORMATION technology; Subject Term: CAPITALISTS & financiers; Subject Term: PARTNERSHIP (Business); Subject Term: BUSINESS enterprises; Subject Term: STOCKHOLDERS; NAICS/Industry Codes: 541619 Other management consulting services; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 541611 Administrative Management and General Management Consulting Services; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Permutt, Thomas1, thomas.permutt@fda.hhs.gov
T1 - A Note on Stratification in Clinical Trials.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2007/11//
Y1 - 2007/11//
VL - 41
IS - 6
CP - 6
M3 - Article
SP - 719
EP - 722
SN - 00928615
AB - Stratification is sometimes proposed to deal with problems of influential covariates in clinical trials. The word stratification, however, may refer to any of four different methods of design and analysis. The methods are capable of addressing three different problems. Which problem and which method are being discussed is often misunderstood. Consequently, the method adopted may not solve the problem that provoked its consideration. [ABSTRACT FROM AUTHOR]
KW - Experimental design
KW - Clinical trials
KW - Medical experimentation on humans
KW - Experimental medicine
KW - Medical research
KW - Statistics
KW - Adjustment
KW - Analysis of covariance
KW - Imbalance
KW - Interaction
KW - Stratification
N1 - Accession Number: 27579435; Authors: Permutt, Thomas 1 Email Address: thomas.permutt@fda.hhs.gov; Affiliations: 1: Director, Division of Biometrics 1I, Center for Drug Evaluation and Research, Food and Drag Administration, Silver Spring, Maryland; Subject: Clinical trials; Subject: Experimental design; Subject: Medical experimentation on humans; Subject: Experimental medicine; Subject: Medical research; Subject: Statistics; Author-Supplied Keyword: Adjustment; Author-Supplied Keyword: Analysis of covariance; Author-Supplied Keyword: Imbalance; Author-Supplied Keyword: Interaction; Author-Supplied Keyword: Stratification; Number of Pages: 4p; Illustrations: 1 Chart; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Feng, Peter C. H.
AU - Monday, Steven R.
AU - Lacher, David W.
AU - Allison, Lesley
AU - Siitonen, Anja
AU - Keys, Christine
AU - Eklund, Marjut
AU - Nagano, Hideki
AU - Karch, Helge
AU - Keen, James
AU - Whittam, Thomas S.
T1 - Genetic diversity among clonal lineages within Escherichia coli O157:H7 stepwise evolutionary model.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/11//
VL - 13
IS - 11
M3 - journal article
SP - 1701
EP - 1706
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Escherichia coli O157:H7 variants were examined for trait mutations and by molecular subtyping to better define clonal complexes postulated on the O157:H7 evolution model. Strains of beta-glucuronidase-positive, sorbitol-negative O157:H7 isolated in United States and Japan were identical to A5 clonal strain and shared sequence type (ST)-65 by multilocus sequence typing (MLST); thus, they belong in A5. However, these strains exhibited pulsed-field gel electrophoresis (PFGE) profile differences that suggested genomic divergence between populations. Sorbitol-fermenting O157 (SFO157) strains from Finland, Scotland, and Germany were identical to A4 clonal strain and belong in A4. Some SFO157 strains, isolated years apart and from different countries, had identical PFGE profiles, suggesting a common origin. Despite similarities, some Finnish and Scottish and all of the German strains have ST-75 ("German clone"), whereas others have ST-76, a new variant ("Scottish clone"). MLST of strains in other clonal complexes also discriminated strains thought to be identical and showed that genetic differences will further distinguish clonal populations into subclones. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Evolution (Biology)
KW - Population genetics
KW - Escherichia coli O157:H7
KW - Nucleotide sequence
KW - United States
KW - Japan
KW - Finland
KW - Scotland
N1 - Accession Number: 27495653; Feng, Peter C. H. 1; Email Address: peter.feng@fda.hhs.gov; Monday, Steven R. 1; Lacher, David W. 2; Allison, Lesley 3; Siitonen, Anja 4; Keys, Christine 1; Eklund, Marjut 4; Nagano, Hideki 5; Karch, Helge 6; Keen, James 7; Whittam, Thomas S. 2; Affiliations: 1: Food and Drug Administration, College Park, Maryland, USA; 2: Michigan State University, East Lansing, Michigan, USA; 3: Western General Hospital, Edinburgh, Scotland; 4: National Public Health Institute, Helsinki, Finland; 5: Hokkaido Institute of Public Health, Hokkaido, Japan; 6: University of Munster, Munster, Germany; 7: US Department of Agriculture, Clay Center, Nebraska, USA; Issue Info: Nov2007, Vol. 13 Issue 11, p1701; Thesaurus Term: Mutation (Biology); Thesaurus Term: Evolution (Biology); Thesaurus Term: Population genetics; Subject Term: Escherichia coli O157:H7; Subject Term: Nucleotide sequence; Subject: United States; Subject: Japan; Subject: Finland; Subject: Scotland; Number of Pages: 6p; Illustrations: 3 Diagrams, 2 Charts; Document Type: journal article
L3 - 10.3201/eid1311.070381
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Balbus, John M.
AU - Maynard, Andrew D.
AU - Colvin, Vicki L.
AU - Castranova, Vincent
AU - Daston, George P.
AU - Denison, Richard A.
AU - Dreher, Kevin L.
AU - Goering, Peter L.
AU - Goldberg, Alan M.
AU - Kulinowski, Kristen M.
AU - Monteiro-Riviere, Nancy A.
AU - Oberdörster, Günter
AU - Omenn, Gilbert S.
AU - Pinkerton, Kent E.
AU - Ramos, Kenneth S.
AU - Rest, Kathleen M.
AU - Sass, Jennifer B.
AU - Silbergeld, Ellen K.
AU - Wong, Brian A.
T1 - Meeting Report: Hazard Assessment for Nanoparticles--Report from an Interdisciplinary Workshop.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2007/11//
VL - 115
IS - 11
M3 - Article
SP - 1654
EP - 1659
PB - Superintendent of Documents
SN - 00916765
AB - In this report we present the findings from a nanotoxicology workshop held 6-7 April 2006 at the Woodrow Wilson International Center for Scholars in Washington, DC. Over 2 days, 26 scientists from government, academia, industry, and nonprofit organizations addressed two specific questions: what information is needed to understand the human health impact of engineered nanoparticles and how is this information best obtained? To assess hazards of nanoparticles in the near-term, most participants noted the need to use existing in vivo toxicologic tests because of their greater familiarity and interpretability. For all types of toxicology tests, the best measures of nanoparticle dose need to be determined. Most participants agreed that a standard set of nanoparticles should be validated by laboratories worldwide and made available for benchmarking tests of other newly created nanoparticles. The group concluded that a battery of tests should be developed to uncover particularly hazardous properties. Given the large number of diverse materials, most participants favored a tiered approach. Over the long term, research aimed at developing a mechanistic understanding of the numerous characteristics that influence nanoparticle toxicity was deemed essential. Predicting the potential toxicity of emerging nanoparticles will require hypothesis-driven research that elucidates how physicochemical parameters influence toxic effects on biological systems. Research needs should be determined in the context of the current availability of testing methods for nanoscale particles. Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Experimental toxicology
KW - Nanoparticles
KW - Toxicology -- Congresses
KW - Technical reports
KW - Workshops (Adult education)
KW - Washington (D.C.)
KW - nanomaterials
KW - nanoparticle
KW - nanotechnology
KW - nanotoxicology
KW - particle toxicology
N1 - Accession Number: 27779923; Balbus, John M. 1; Email Address: jbalbus@environmentaldefense.org; Maynard, Andrew D. 2; Colvin, Vicki L. 3; Castranova, Vincent 4; Daston, George P. 5; Denison, Richard A. 1; Dreher, Kevin L. 6; Goering, Peter L. 7; Goldberg, Alan M. 8; Kulinowski, Kristen M. 3; Monteiro-Riviere, Nancy A. 9; Oberdörster, Günter 10; Omenn, Gilbert S. 11; Pinkerton, Kent E. 12; Ramos, Kenneth S. 13; Rest, Kathleen M. 14; Sass, Jennifer B. 15; Silbergeld, Ellen K. 8; Wong, Brian A. 16; Affiliations: 1: Environmental Defense, Washington, DC, USA.; 2: Woodrow Wilson International Center for Scholars, Washington, DC, USA.; 3: Rice University, Houston, Texas, USA.; 4: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; 5: Procter and Gamble, Cincinnati, Ohio, USA.; 6: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.; 7: Food and Drug Administration, Rockville, Maryland, USA.; 8: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; 9: North Carolina State University, Raleigh, North Carolina, USA.; 10: University of Rochester, Rochester, New York, USA.; 11: University of Michigan, Ann Arbor, Michigan, USA.; 12: University of California at Davis, Davis, California, USA.; 13: University of Louisville, Louisville, Kentucky, USA.; 14: Union of Concerned Scientists, Cambridge, Massachusetts, USA.; 15: Natural Resources Defense Council, Washington, DC, USA.; 16: Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.; Issue Info: Nov2007, Vol. 115 Issue 11, p1654; Thesaurus Term: Health risk assessment; Thesaurus Term: Experimental toxicology; Subject Term: Nanoparticles; Subject Term: Toxicology -- Congresses; Subject Term: Technical reports; Subject Term: Workshops (Adult education); Subject: Washington (D.C.); Author-Supplied Keyword: nanomaterials; Author-Supplied Keyword: nanoparticle; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: nanotoxicology; Author-Supplied Keyword: particle toxicology; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 3 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Curwin, Brian D.
AU - Hein, Misty J.
AU - Sanderson, Wayne T.
AU - Striley, Cynthia
AU - Heederik, Dick
AU - Kromhout, Hans
AU - Reynolds, Stephen J.
AU - Alavanja, Michael C.
T1 - Pesticide dose estimates for children of Iowa farmers and non-farmers
JO - Environmental Research
JF - Environmental Research
Y1 - 2007/11//
VL - 105
IS - 3
M3 - Article
SP - 307
EP - 315
SN - 00139351
AB - Abstract: Farm children have the potential to be exposed to pesticides. Biological monitoring is often employed to assess this exposure; however, the significance of the exposure is uncertain unless doses are estimated. In the spring and summer of 2001, 118 children (66 farm, 52 non-farm) of Iowa farm and non-farm households were recruited to participate in a study investigating potential take-home pesticide exposure. Each child provided an evening and morning urine sample at two visits spaced approximately 1 month apart, with the first sample collection taken within a few days after pesticide application. Estimated doses were calculated for atrazine, metolachlor, chlorpyrifos, and glyphosate from urinary metabolite concentrations derived from the spot urine samples and compared to EPA reference doses. For all pesticides except glyphosate, the doses from farm children were higher than doses from the non-farm children. The difference was statistically significant for atrazine (p<0.0001) but only marginally significant for chlorpyrifos and metolachlor (p=0.07 and 0.1, respectively). Among farm children, geometric mean doses were higher for children on farms where a particular pesticide was applied compared to farms where that pesticide was not applied for all pesticides except glyphosate; results were significant for atrazine (p=0.030) and metolachlor (p=0.042), and marginally significant for chlorpyrifos (p=0.057). The highest estimated doses for atrazine, chlorpyrifos, metolachlor, and glyphosate were 0.085, 1.96, 3.16, and 0.34μg/kg/day, respectively. None of the doses exceeded any of the EPA reference values for atrazine, metolachlor, and glyphosate; however, all of the doses for chlorpyrifos exceeded the EPA chronic population adjusted reference value. Doses were similar for male and female children. A trend of decreasing dose with increasing age was observed for chlorpyrifos. [Copyright &y& Elsevier]
AB - Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Farmers
KW - Pesticides -- Environmental aspects
KW - Environmental exposure
KW - Pesticides -- Application
KW - Pesticides -- Environmental aspects -- Measurement
KW - Cholinesterase-inhibiting insecticides
KW - Juvenile diseases -- Risk factors
KW - Urinalysis
KW - Atrazine -- Environmental aspects
KW - Chlorpyrifos -- Environmental aspects
KW - Organophosphorus compounds
KW - Biological monitoring
KW - Children
KW - Dose
KW - Exposure
KW - Herbicides
KW - Insecticides
KW - Pesticides
KW - Urine
N1 - Accession Number: 27034482; Curwin, Brian D. 1; Email Address: bcurwin@cdc.gov; Hein, Misty J. 1; Sanderson, Wayne T. 2; Striley, Cynthia 3; Heederik, Dick 4; Kromhout, Hans 4; Reynolds, Stephen J. 5; Alavanja, Michael C. 6; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226, USA; 2: Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA; 3: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH, USA; 4: Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; 5: Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; 6: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA; Issue Info: Nov2007, Vol. 105 Issue 3, p307; Thesaurus Term: Farmers; Thesaurus Term: Pesticides -- Environmental aspects; Thesaurus Term: Environmental exposure; Thesaurus Term: Pesticides -- Application; Thesaurus Term: Pesticides -- Environmental aspects -- Measurement; Thesaurus Term: Cholinesterase-inhibiting insecticides; Subject Term: Juvenile diseases -- Risk factors; Subject Term: Urinalysis; Subject Term: Atrazine -- Environmental aspects; Subject Term: Chlorpyrifos -- Environmental aspects; Subject Term: Organophosphorus compounds; Author-Supplied Keyword: Biological monitoring; Author-Supplied Keyword: Children; Author-Supplied Keyword: Dose; Author-Supplied Keyword: Exposure; Author-Supplied Keyword: Herbicides; Author-Supplied Keyword: Insecticides; Author-Supplied Keyword: Pesticides; Author-Supplied Keyword: Urine; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.envres.2007.06.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105827340
T1 - New procedure for assessing sequential manual lifting jobs using the revised NIOSH lifting equation.
AU - Waters TR
AU - Lu ML
AU - Occhipinti E
Y1 - 2007/11//
N1 - Accession Number: 105827340. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Occupational Health
KW - Weight Lifting
KW - Weight-Bearing
KW - Biomechanics
KW - Health Status Indicators
KW - Italy
KW - Models, Theoretical
KW - National Institute for Occupational Safety and Health
KW - Risk Assessment
KW - Task Performance and Analysis
KW - United States
KW - Human
SP - 1761
EP - 1770
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 50
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A sequential manual lifting job is defined as a job where workers rotate between a series of manual lifting rotation slots or elements at specified time intervals during the course of a work shift. The original NIOSH lifting equation lacked a method for assessing the physical demands of these types of jobs. This paper presents the sequential lifting index (SLI), a new conceptual method for assessing the physical demands for sequential manual lifting jobs. The new method is similar to the composite lifting index (CLI) method that was provided by NIOSH for assessing multi-task jobs. The SLI method expands upon the methods originally provided by NIOSH by providing a simple method for estimating the relative magnitude of physical stress for sequential manual lifting jobs. It should also be useful in assisting safety and health specialists to prioritize or rank hazardous jobs within a plant.
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
U2 - PMID: 17972201.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hammad, Tarek A.
T1 - Review: Benefits of antidepressants outweigh risks of suicidal ideation and attempts in children and adolescents.
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
Y1 - 2007/11//
VL - 10
IS - 4
M3 - Article
SP - 108
EP - 108
SN - 13620347
AB - The article examines the effectiveness of antidepressants for pediatric major depressive disorder (MDD), obsessive compulsive disorder (OCD) and non-OCD anxiety disorders. It also studies whether antidepressants increase suicidal ideation and suicide attempts. The article shows that antidepressants increase response compared with placebo for MDD, OCD and non-OCD anxiety disorders in children and adolescents.
KW - ANTIDEPRESSANTS
KW - MENTAL depression
KW - OBSESSIVE-compulsive disorder
KW - ANXIETY disorders
KW - CHILD mental health
KW - TEENAGERS -- Mental health services
N1 - Accession Number: 27472026; Hammad, Tarek A. 1; Affiliation: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD, USA; Source Info: Nov2007, Vol. 10 Issue 4, p108; Subject Term: ANTIDEPRESSANTS; Subject Term: MENTAL depression; Subject Term: OBSESSIVE-compulsive disorder; Subject Term: ANXIETY disorders; Subject Term: CHILD mental health; Subject Term: TEENAGERS -- Mental health services; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105867032
T1 - Review: benefits of antidepressants outweigh risks of suicidal ideation and attempts in children and adolescents.
AU - Hammad TA
Y1 - 2007/11//
N1 - Accession Number: 105867032. Language: English. Entry Date: 20080321. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Original Study: Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. (JAMA) 4/18/2007; 297 (15): 1683-1696. Journal Subset: Biomedical; Europe; UK & Ireland. Special Interest: Evidence-Based Practice; Psychiatry/Psychology. NLM UID: 100883413.
KW - Antidepressive Agents -- Adverse Effects
KW - Antidepressive Agents -- Therapeutic Use
KW - Suicidal Ideation -- Risk Factors
KW - Adolescence
KW - Child
KW - Clinical Trials
KW - Meta Analysis
KW - Systematic Review
SP - 108
EP - 108
JO - Evidence Based Mental Health
JF - Evidence Based Mental Health
JA - EVID BASED MENT HEALTH
VL - 10
IS - 4
PB - BMJ Publishing Group
AB - How effective are antidepressants for paediatric major depressive disorder, obsessive compulsive disorder (OCD) and non-OCD anxiety disorders, and do they increase suicidal ideation or suicide attempts?METHODSDesign: Systematic review with meta-analysis.Data sources: PubMed (January 1988 to July 2006); abstracts of scientific meetings; FDA and MHRA reports; reference lists of articles; clinical trial registries; and contact with authors.Study selection and analysis: Randomised controlled trials (RCTs) comparing second generation antidepressants versus placebo, in children and adolescents (aged <19 years) with major depressive disorder (MDD), OCD or non-OCD anxiety disorders. Data on suicide outcomes were obtained from an FDA review of antidepressants and paediatric suicidal behaviour, study reports and from investigators. Exclusions were: studies of tricyclic antidepressants or monoamine oxidase inhibitors; crossover RCTs; studies in treatment responders only; studies still recruiting patients; use of cognitive behavioural therapy; inability to obtain data from author; or studies of anxiety-related indications other than separation, social or generalised anxiety disorder. Mantel-Haenszel and DerSimonian and Laird methods were used to calculate risk differences for dichotomous outcomes. Heterogeneity was assessed using the Cochran Q statistic and the I[2] statistic. Publication bias was assessed using funnel plots, adjusted rank correlation tests, and regression analysis.Outcomes: Response (using primary response measure defined by individual studies), suicidal ideation/attempt (as rated in the FDA analysis, or using the Columbia coding scheme).MAIN RESULTSTwenty seven RCTs met the inclusion criteria, including 15 in children and adolescents with MDD (n = 3430), 6 in OCD (n = 718), and 6 in non-OCD anxiety disorders (n = 1162). For MDD, OCD and non-OCD anxiety disorders, antidepressants increased response compared to placebo (see http://ebmh.bmj.com/supplemental for table; p<0.001 for all comparisons). The numbers needed to treat to observe one response were 10 for MDD (95% CI 7 to 15), 6 for OCD (95% CI 4 to 8) and 3 for non-OCD anxiety disorders (95% CI 2 to 5). Overall, if all indications were pooled, there was a significant increase in suicidal ideation/attempts with antidepressants compared with placebo (risk difference 0.7%, 95% CI 0.1% to 1.3%; numbers needed to harm 143, 95% CI 77 to 1000; RR 1.7, 95% CI 1.1 to 2.7; random effects analysis). If MDD, OCD and non-OCD anxiety disorders were analysed separately there was still a trend towards increased suicidal ideation/attempts, but this difference did not reach significance in random effects analyses (see table). There were no completed suicides in any of the included studies. The review found no evidence of publication bias.CONCLUSIONSAntidepressants increase response compared with placebo for MDD, OCD, and non-OCD anxiety disorders in children and adolescents. There is a small increase in suicidal ideation/attempts with antidepressants across these indications. The numbers needed to treat to observe response are smaller than those needed to observe suicidal ideation/attempts; therefore the balance is in favour of benefit over harm.NOTESResults for response for non-OCD anxiety disorders should be interpreted with caution because there was significant heterogeneity in this analysis, which could not be explained solely by removing the small pilot study that had the largest treatment effect.
SN - 1362-0347
AD - Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD, USA.
U2 - PMID: 17962653.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yuan, Bao-Zhu
AU - Jefferson, Amy M.
AU - Millecchia, Lyndell
AU - Popescu, Nicholas C.
AU - Reynolds, Steven H.
T1 - Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells
JO - Experimental Cell Research
JF - Experimental Cell Research
Y1 - 2007/11//
VL - 313
IS - 18
M3 - Article
SP - 3868
EP - 3880
SN - 00144827
AB - Abstract: We have previously shown that reactivation of DLC1, a RhoGAP containing tumor suppressor gene, inhibits tumorigenicity of human non-small cell lung carcinoma cells (NSCLC). After transfection of NSCLC cells with wild type (WT) DLC1, changes in cell morphology were observed. To determine whether such changes have functional implications, we generated several DLC1 mutants and examined their effects on cell morphology, proliferation, migration and apoptosis in a DLC1 deficient NSCLC cell line. We show that WT DLC1 caused actin cytoskeleton-based morphological alterations manifested as cytoplasmic extensions and membrane blebbings in most cells. Subsequently, a fraction of cells exhibiting DLC1 protein nuclear translocation (PNT) underwent caspase 3-dependent apoptosis. We also show that the RhoGAP domain is essential for the occurrence of morphological alterations, PNT and apoptosis, and the inhibition of cell migration. DLC1 PNT is dependent on a bipartite nuclear localizing sequence and most likely is regulated by a serine-rich domain at N-terminal part of the DLC1 protein. Also, we found that DLC1 functions in the cytoplasm as an inhibitor of tumor cell proliferation and migration, but in the nucleus as an inducer of apoptosis. Our analyses provide evidence for a possible link between morphological alterations, PNT and proapoptotic and anti-oncogenic activities of DLC1 in lung cancer. [Copyright &y& Elsevier]
AB - Copyright of Experimental Cell Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIONCOGENES
KW - CELL death
KW - APOPTOSIS
KW - LUNGS -- Cancer
KW - Apoptosis
KW - DLC1
KW - Morphology
KW - NSCLC
KW - Protein nuclear translocation
N1 - Accession Number: 27139817; Yuan, Bao-Zhu 1; Email Address: bby1@cdc.gov Jefferson, Amy M. 1 Millecchia, Lyndell 1 Popescu, Nicholas C. 2 Reynolds, Steven H. 1; Affiliation: 1: Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA 2: Laboratory of Experimental Carcinogenesis, NCI, NIH, Bethesda, MD 28092, USA; Source Info: Nov2007, Vol. 313 Issue 18, p3868; Subject Term: ANTIONCOGENES; Subject Term: CELL death; Subject Term: APOPTOSIS; Subject Term: LUNGS -- Cancer; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: DLC1; Author-Supplied Keyword: Morphology; Author-Supplied Keyword: NSCLC; Author-Supplied Keyword: Protein nuclear translocation; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.yexcr.2007.08.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27139817&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hui-Young Lee
AU - Sun-A Cho
AU - In-Soo Lee
AU - Jong-Hwan Park
AU - Seung-Hyeok Seok
AU - Min-Won Baek
AU - Dong-Jae Kim
AU - Seok-Ho Lee
AU - Sook-Jin Hur
AU - Sang-Ja Ban
AU - Yoo-Kyoung Lee
AU - Yang-Keum Han
AU - Young-Keun Cho
AU - Jae-Hak ParkI
T1 - Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice.
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2007/11//
VL - 51
IS - 2
M3 - Article
SP - 310
EP - 318
SN - 09288244
AB - The attenuation and immunoenhancing effects of rpoS and phoP Salmonella enterica serovar strain Typhi ( Salmonella typhi) mutants have not been compared. Here, three S. typhi deletion mutants ( phoP, rpoS, and rpoS–phoP double mutant) are constructed and these mutants are characterized with respect to invasiveness, virulence, and protective immune response compared with wild-type Ty2. It was found that phoP and phoP–rpoS deletion mutants are less invasive to HT-29 cells than the wild-type Ty2 and the rpoS single-deleted strain. The LD50 of immunized mice was higher for phoP than for rpoS mutants, and the highest for the phoP–rpoS double mutant. In addition, all S. typhi mutants showed an increase in the specific serum IgG levels and T-cell-mediated immunity, and showed equal protection abilities against a wild-type Ty2 challenge after two rounds of immunization in BALB/c mice. It is concluded that phoP genes appear to play a more important role than rpoS genes in both cellular invasion and virulence of S. typhi, but not in immunogenicity in mice. Furthermore, the data indicate that the phoP–rpoS double mutant may show promise as a candidate for an attenuated typhoid vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA diseases
KW - SALMONELLA typhi
KW - MICROBIAL invasiveness
KW - VIRULENCE (Microbiology)
KW - IMMUNE response
KW - IMMUNOGLOBULIN G
KW - IMMUNITY
KW - IMMUNIZATION
KW - TYPHOID vaccine
KW - attenuation
KW - invasiveness
KW - mouse
KW - phoP
KW - rpoS
KW - Salmonella enterica serovar strain Typhi
N1 - Accession Number: 26913657; Hui-Young Lee 1 Sun-A Cho 1 In-Soo Lee 2 Jong-Hwan Park 1 Seung-Hyeok Seok 1 Min-Won Baek 1 Dong-Jae Kim 1 Seok-Ho Lee 3 Sook-Jin Hur 3 Sang-Ja Ban 3 Yoo-Kyoung Lee 3 Yang-Keum Han 4 Young-Keun Cho 2 Jae-Hak ParkI 1; Email Address: pjhak@snu.ac.kr; Affiliation: 1: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea 2: Department of Biotechnology, Hannam University, Daedeok-gu, Daejon, Korea 3: Biological Evaluation Department, Bacterial Products Division, Korean Food and Drug Administration, Eunpyung-gu, Seoul, Korea 4: Daejeon Health Science College, Dong-gu, Daejeon, Korea; Source Info: Nov2007, Vol. 51 Issue 2, p310; Subject Term: SALMONELLA diseases; Subject Term: SALMONELLA typhi; Subject Term: MICROBIAL invasiveness; Subject Term: VIRULENCE (Microbiology); Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULIN G; Subject Term: IMMUNITY; Subject Term: IMMUNIZATION; Subject Term: TYPHOID vaccine; Author-Supplied Keyword: attenuation; Author-Supplied Keyword: invasiveness; Author-Supplied Keyword: mouse; Author-Supplied Keyword: phoP; Author-Supplied Keyword: rpoS; Author-Supplied Keyword: Salmonella enterica serovar strain Typhi; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1574-695X.2007.00307.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26913657&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parks, Christine G.
AU - Andrew, Michael E.
AU - Blanciforti, Laura A.
AU - Luster, Michael I.
T1 - Variation in the WBC differential count and other factors associated with reporting of herpes labialis: A population-based study of adults.
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2007/11//
VL - 51
IS - 2
M3 - Article
SP - 336
EP - 343
SN - 09288244
AB - Reactivation of latent herpes virus has been linked to triggers of mild immunosupression, such as stress or UV-exposure. Despite having predictive value in severe immunodeficiency, the white blood cell (WBC) differential count has not been examined in relation to risk of herpes reactivation in population studies. The WBC differential count and other risk factors for herpes labialis were examined in 5687 adults (ages 18–64) from the Third National Health and Nutrition Examination Survey, who had WBC 3.5–11 × 106 cells mL−1 and reported no acute infections in the past month. The association between self-reported herpes labialis in the past year and the WBC differential count was modeled, adjusting for age, sex, race/ethnicity, education, smoking, upper respiratory infections (URI), and HSV-1 antibodies. Herpes labialis was significantly associated with white race/ethnicity, being a nonsmoker, and frequent URI. Compared with the highest quartile, being in the lowest quartile of granulocytes was associated with herpes labialis, adjusted odds ratio=1.82 (95% confidence interval 1.20, 2.28). At the same time, there was a trend towards an inverse association of lower lymphocyte count and herpes labialis. These findings suggest that moderate differences in the WBC differential count are related to reactivation of HSV-1. Prospective studies may help to show whether such differences indicate susceptibility to loss of latency or represent a consequence of reactivated infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOSUPPRESSION
KW - IMMUNODEFICIENCY
KW - LEUCOCYTES
KW - HERPESVIRUS diseases
KW - VIRUS diseases
KW - DISEASES -- Risk factors
KW - IMMUNOGLOBULINS
KW - GRANULOCYTES
KW - DISEASE susceptibility
KW - fever blisters
KW - herpes labialis/epidemiology
KW - labialis virus/immunology
KW - leukocytes
N1 - Accession Number: 26913650; Parks, Christine G. 1; Email Address: cqp8@cdc.gov Andrew, Michael E. 1 Blanciforti, Laura A. 1 Luster, Michael I. 1; Affiliation: 1: Biostatistics and Epidemiology Branch and Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Nov2007, Vol. 51 Issue 2, p336; Subject Term: IMMUNOSUPPRESSION; Subject Term: IMMUNODEFICIENCY; Subject Term: LEUCOCYTES; Subject Term: HERPESVIRUS diseases; Subject Term: VIRUS diseases; Subject Term: DISEASES -- Risk factors; Subject Term: IMMUNOGLOBULINS; Subject Term: GRANULOCYTES; Subject Term: DISEASE susceptibility; Author-Supplied Keyword: fever blisters; Author-Supplied Keyword: herpes labialis/epidemiology; Author-Supplied Keyword: labialis virus/immunology; Author-Supplied Keyword: leukocytes; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1574-695X.2007.00314.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=26913650&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Surh, J.
AU - Lee, S.
AU - Kwon, H.
T1 - 4-Hydroxy-2-alkenals in polyunsaturated fatty acids-fortified infant formulas and other commercial food products.
JO - Food Additives & Contaminants
JF - Food Additives & Contaminants
Y1 - 2007/11//
VL - 24
IS - 11
M3 - Article
SP - 1209
EP - 1218
PB - Taylor & Francis Ltd
SN - 0265203X
AB - 4-Hydroxy-2-hexenal (HHE) and 4-hydroxy-2-nonenal (HNE) were determined using selected ion-monitoring gas chromatography-mass spectrometry (GC-MS) in 56 kinds of commercially available PUFA-fortified foods including infant formulas and baby foods. HHE and HNE, each specifically coming from the oxidation of n-3 and n-6 polyunsaturated fatty acids (PUFA), were observed at <10-77 and 41-132 µg kg-1 in the infant formulas (n = 12) and at <10-52 and 36-116 µg kg-1 in the baby foods (n = 7), respectively. 4-Hydroxy-2-alkenals in infant formulas and baby foods were further determined at 10 and 30 days after opening in an attempt to examine the time dependence of the levels of 4-hydroxy-2-alkenals. The values of HHE and HNE had increased appreciably to <10-220 and 79-792 µg kg-1 in infant formulas and to <10-112 and 135-572 µg kg-1 in baby foods, respectively, at 10 days and decreased, although statistically not significant, in most of the tested samples after 30 days, which suggested that the reactive compounds might interact with other constituents like proteins in the samples to form adducts or be decomposed with time. Based on the current study, it was calculated that 3-month to 1-year-old babies maintained exclusively on these commercially available PUFA-fortified infant formulas or baby foods could be exposed to a maximum of 20.2 µg kg-1 body weight day-1 of 4-hydroxy-2-alkenals, which is two orders of magnitude higher than the exposure of Korean adults estimated in a previous study of the authors' (2005). The present study may trigger future studies investigating the physiological influence of 4-hydroxy-2-alkenals originating from the diet on man at an early stage of development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gas chromatography
KW - Mass spectrometry
KW - Body composition
KW - Hydroxy acids
KW - Unsaturated fatty acids
KW - Infant formulas
KW - Baby foods
KW - Infant nutrition
KW - Food -- Protein content
KW - 4-Hydroxy-2-alkenals
KW - 4-hydroxy-2-hexenal (HHE)
KW - 4-hydroxy-2-nonenal (HNE)
KW - baby foods
KW - exposure
KW - infant formulas
KW - polyunsaturated fatty acids
N1 - Accession Number: 27009683; Surh, J. 1; Lee, S. 2,3; Kwon, H. 2,4; Email Address: hjkwon@snu.ac.kr; Affiliations: 1: Department of Food and Nutrition, College of Health and Welfare, Kangwon National University, Samcheok, Gangwondo 245-711, Korea; 2: Department of Food and Nutrition, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-742, Korea; 3: Import Management Team, Korea Food and Drug Administration, 120 Juahn 1 dong, Namgu, Incheon 402-835, Korea; 4: Research Institute of Human Ecology, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-742, Korea; Issue Info: Nov2007, Vol. 24 Issue 11, p1209; Thesaurus Term: Gas chromatography; Thesaurus Term: Mass spectrometry; Thesaurus Term: Body composition; Subject Term: Hydroxy acids; Subject Term: Unsaturated fatty acids; Subject Term: Infant formulas; Subject Term: Baby foods; Subject Term: Infant nutrition; Subject Term: Food -- Protein content; Author-Supplied Keyword: 4-Hydroxy-2-alkenals; Author-Supplied Keyword: 4-hydroxy-2-hexenal (HHE); Author-Supplied Keyword: 4-hydroxy-2-nonenal (HNE); Author-Supplied Keyword: baby foods; Author-Supplied Keyword: exposure; Author-Supplied Keyword: infant formulas; Author-Supplied Keyword: polyunsaturated fatty acids; NAICS/Industry Codes: 311420 Fruit and vegetable canning, pickling and drying; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/02652030701422465
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Himelhoch, Seth
AU - Chander, Geetanjali
AU - Fleishman, John A.
AU - Hellinger, James
AU - Gaist, Paul
AU - Gebo, Kelly A.
T1 - Access to HAART and utilization of inpatient medical hospital services among HIV-infected patients with co-occurring serious mental illness and injection drug use
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
Y1 - 2007/11//
VL - 29
IS - 6
M3 - Article
SP - 518
EP - 525
SN - 01638343
AB - Abstract: Objective: Among HIV-infected individuals, we examined whether having co-occurring serious mental illness (SMI) and injection drug use (IDU) impacts: (a) receipt of highly active antiretroviral therapy (HAART), and (b) utilization of inpatient HIV services, compared to those who have SMI only, IDU only or neither SMI nor IDU. Method: Demographic, clinical and resource utilization data were collected from medical records of 5119 patients in HIV primary care at four US HIV care sites in different geographic regions with on-site mental health services in 2001. We analyzed receipt of HAART using multivariate logistic regression and the number of medical hospital admissions using multivariate logistic and Poisson regression analyses, which controlled for demographic factors, receipt of HAART, CD4 count and HIV-1 RNA. Results: Those with co-occurring SMI and IDU [adjusted odds ratio (AOR)=0.52; 95% confidence interval (95% CI)=0.41–0.81] and those with IDU alone (AOR=0.64; 95% CI=0.58–0.85) were significantly less likely to receive HAART than those with neither SMI nor IDU, controlling for demographic and clinical factors. Those with co-occurring SMI and IDU were more likely to use any inpatient medical services (AOR=2.22; 95% CI=1.64–3.01) and were significantly more likely to use them more frequently (incidence rate ratio=1.33; 95% CI=1.13–1.55) than those with neither SMI nor IDU, SMI only or IDU only. Conclusion: HIV-infected individuals with co-occurring SMI and IDU are significantly more likely to utilize HIV-related medical inpatient services than individuals with no comorbidity or with only one comorbidity. Individuals with both SMI and IDU did not differ from those with IDU only in receipt of HAART. Inpatient hospitalizations are expensive, and efforts should be targeted towards these populations to reduce potentially avoidable inpatient care. [Copyright &y& Elsevier]
AB - Copyright of General Hospital Psychiatry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - MEDICAL records
KW - DISEASES
KW - MILITARY hospitals
KW - HAART
KW - HIV-infected patients
KW - Inpatient medical hospital services
N1 - Accession Number: 27531079; Himelhoch, Seth 1; Email Address: shimelho@psych.umaryland.edu Chander, Geetanjali 2 Fleishman, John A. 3 Hellinger, James 4 Gaist, Paul 5 Gebo, Kelly A. 2; Affiliation: 1: Division of Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21212, USA 2: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 3: Agency for Healthcare Research and Quality, Rockville, MD, USA 4: Tufts University, Boston, MA, USA 5: Office of AIDS Research, National Institute of Health, Bethesda, MD, USA; Source Info: Nov2007, Vol. 29 Issue 6, p518; Subject Term: HIV-positive persons; Subject Term: MEDICAL records; Subject Term: DISEASES; Subject Term: MILITARY hospitals; Author-Supplied Keyword: HAART; Author-Supplied Keyword: HIV-infected patients; Author-Supplied Keyword: Inpatient medical hospital services; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.genhosppsych.2007.03.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bast, Robert C.
AU - Thigpen, J. Tate
AU - Arbuck, Susan G.
AU - Basen-Engquist, Karen
AU - Burke, Laurie B.
AU - Freedman, Ralph
AU - Horning, Sandra J.
AU - Ozols, Robert
AU - Rustin, Gordon J.
AU - Spriggs, David
AU - Wenzel, Lari B.
AU - Pazdur, Richard
T1 - Clinical trial endpoints in ovarian cancer: Report of an FDA/ASCO/AACR Public Workshop
JO - Gynecologic Oncology
JF - Gynecologic Oncology
Y1 - 2007/11//
VL - 107
IS - 2
M3 - Article
SP - 173
EP - 176
SN - 00908258
AB - Abstract: Objective: The unique characteristics of cancer, particularly issues involving the use of surrogate endpoints in clinical trials, present special challenges in the development of cancer drugs. In response, the U.S. Food and Drug Administration (FDA) has partnered with the American Society of Clinical Oncology, the American Association for Cancer Research, and the American Society of Hematology to conduct public workshops evaluating potential endpoints for drug approvals for the most common tumor types. Methods: A workshop evaluating potential endpoints in ovarian cancer drug research was held in Bethesda, Maryland, in April 2006. Invited experts presented research findings and discussed endpoints in trials of drugs for treatment of Stage III and IV ovarian cancer. Results: The panel responded to specific questions from FDA, discussing use of progression-free survival as a surrogate for overall survival and use of CA-125 levels as an indicator of response. Panel members also addressed endpoints in first-line therapy, second-line and subsequent therapy, and maintenance therapy. Conclusion: Expert commentary provided by panel members will inform FDA''s draft guidance on clinical endpoints for cancer drug approvals and will be discussed at meetings of the FDA''s Oncologic Drugs Advisory Committee. FDA intends to develop a set of principles that can be used to define efficacy standards for drugs used to treat ovarian and other cancers. [Copyright &y& Elsevier]
AB - Copyright of Gynecologic Oncology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - MEDICAL research
KW - MEDICAL experimentation on humans
KW - TUMORS
KW - Approval
KW - CA125
KW - Cancer
KW - Endpoints
KW - FDA
KW - Ovarian
KW - Research
KW - Therapy
N1 - Accession Number: 27139627; Bast, Robert C. 1 Thigpen, J. Tate 2; Email Address: jtthigpen@att.net Arbuck, Susan G. 3 Basen-Engquist, Karen 1 Burke, Laurie B. 4 Freedman, Ralph 1 Horning, Sandra J. 5 Ozols, Robert 6 Rustin, Gordon J. 7 Spriggs, David 8 Wenzel, Lari B. 9 Pazdur, Richard 4; Affiliation: 1: M. D. Anderson Cancer Center, Houston, TX, USA 2: University of Mississippi Medical Center, Jackson, MS, USA 3: Schering-Plough Research Institute, Kenilworth, NJ, USA 4: U.S. Food and Drug Administration, Rockville, MD, USA 5: Stanford University Cancer Center, Stanford, CA, USA 6: Fox Chase Cancer Center, Philadelphia, PA, USA 7: Mount Vernon Cancer Center, Northwood, Middlesex, UK 8: Memorial Sloan-Kettering Cancer Center, New York, NY, USA 9: University of California-Irvine, Irvine, CA, USA; Source Info: Nov2007, Vol. 107 Issue 2, p173; Subject Term: CANCER treatment; Subject Term: MEDICAL research; Subject Term: MEDICAL experimentation on humans; Subject Term: TUMORS; Author-Supplied Keyword: Approval; Author-Supplied Keyword: CA125; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Endpoints; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Ovarian; Author-Supplied Keyword: Research; Author-Supplied Keyword: Therapy; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ygyno.2007.08.092
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27139627&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bell, Maria C.
AU - Schmidt-Grimminger, Delf
AU - Patrick, Sarah
AU - Ryschon, Tim
AU - Linz, Laurie
AU - Chauhan, Subhash C.
T1 - There is a high prevalence of human papillomavirus infection in American Indian women of the Northern Plains
JO - Gynecologic Oncology
JF - Gynecologic Oncology
Y1 - 2007/11//
VL - 107
IS - 2
M3 - Article
SP - 236
EP - 241
SN - 00908258
AB - Abstract: Objectives: Cervical cancer is the leading gynecological malignancy worldwide, and the incidence of this disease is very high in American Indian women. Infection with the human papillomavirus (HPV) is responsible for more than 95% of cervical squamous carcinomas. Therefore, the main objective of this study was to analyze oncogenic HPV infections in American Indian women residing in the Northern Plains. Methods: Cervical samples were collected from 287 women attending a Northern Plains American Indian reservation outpatient clinic. DNA was extracted from the cervical samples and HPV-specific DNA was amplified by polymerase chain reaction (PCR) using the L1 consensus primer sets. The PCR products were hybridized with the Roche HPV Line Blot assay for HPV genotyping to detect 27 different low- and high-risk HPV genotypes. The Chi-squared test was performed for statistical analysis of the HPV infection and cytology diagnosis data. Results: Of the total 287 patients, 61 women (21.25%) tested positive for HPV infection. Among all HPV-positive women, 41 (67.2%) were infected with high-risk HPV types. Of the HPV infected women, 41% presented with multiple HPV genotypes. Additionally, of the women infected with oncogenic HPV types, 20 (48.7%) were infected with HPV16 and 18 and the remaining 21 (51.3%) were infected with other oncogenic types (i.e., HPV59, 39, 73). Women infected with oncogenic HPV types had significantly higher (p =0.001) abnormal Papanicolaou smear tests (Pap test) compared to women who were either HPV negative or positive for non-oncogenic HPV types. The incidence of HPV infection was inversely correlated (p <0.05) with the age of the patients, but there was no correlation (p =0.33) with seasonal variation. Conclusions: In this study, we observed a high prevalence of HPV infection in American Indian women residing on Northern Plains Reservations. In addition, a significant proportion of the oncogenic HPV infections were other than HPV16 and 18. [Copyright &y& Elsevier]
AB - Copyright of Gynecologic Oncology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER patients
KW - CANCER in women
KW - WOMEN -- Diseases
KW - CERVICAL cancer
KW - American Indian
KW - Cervical cancer
KW - Cervical cancer diagnosis
KW - Human papillomavirus
KW - Northern Plains
N1 - Accession Number: 27139638; Bell, Maria C. 1,2 Schmidt-Grimminger, Delf 2 Patrick, Sarah 3 Ryschon, Tim 4 Linz, Laurie 5 Chauhan, Subhash C. 1,2; Email Address: subhash.chauhan@usd.edu; Affiliation: 1: Cancer Biology Research Institute, Sanford Research, Sanford School of Medicine, The University of South Dakota, Sioux Falls, SD, USA 2: Department of Obstetrics and Gynecology, Sanford School of Medicine, The University of South Dakota, Sioux Falls, SD, USA 3: Center for Rural Health Improvement, Department of Family Medicine, Sanford School of Medicine, The University of South Dakota, Sioux Falls, SD, USA 4: Former Medical Director of an Indian Health Service Unit in South Dakota, USA 5: Director of Cytology, Pathology Consultants, Bismark, ND, USA; Source Info: Nov2007, Vol. 107 Issue 2, p236; Subject Term: CANCER patients; Subject Term: CANCER in women; Subject Term: WOMEN -- Diseases; Subject Term: CERVICAL cancer; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: Cervical cancer; Author-Supplied Keyword: Cervical cancer diagnosis; Author-Supplied Keyword: Human papillomavirus; Author-Supplied Keyword: Northern Plains; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ygyno.2007.06.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105846055
T1 - Faith-based organizations and pandemic preparedness: church-related groups will be vital partners in getting ready for an influenza pandemic.
AU - Santibañez S
Y1 - 2007/11//2007 Nov-Dec
N1 - Accession Number: 105846055. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 8500263.
KW - Community Networks
KW - Influenza -- Epidemiology
KW - Religion and Religions
KW - Animals
KW - Birds
KW - Influenza A Virus, H5N1 Subtype
KW - Influenza -- Prevention and Control
KW - Influenza
KW - Influenza, Avian
KW - United States
SP - 26
EP - 31
JO - Health Progress
JF - Health Progress
JA - HEALTH PROG
VL - 88
IS - 6
CY - Washington, District of Columbia
PB - Catholic Health Association of the United States
SN - 0882-1577
AD - Commander, Department of Health and Human Services, US Public Health Service and Centers for Disease Control and Prevention, Atlanta
U2 - PMID: 18062371.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brock, Tina Penick
AU - Smith, Scott R.
T1 - Using digital videos displayed on personal digital assistants (PDAs) to enhance patient education in clinical settings
JO - International Journal of Medical Informatics
JF - International Journal of Medical Informatics
Y1 - 2007/11//
VL - 76
IS - 11/12
M3 - Article
SP - 829
EP - 835
SN - 13865056
AB - Abstract: Objectives: To evaluate the effects of using an audiovisual animation (i.e., digital video) displayed on a personal digital assistant (PDA) for patient education in a clinical setting. Methods: Quasi-experimental study of a prospective technology intervention conducted in an outpatient infectious diseases clinic at an academic medical center. Subjects responded to questions immediately before, immediately after, and 4–6 weeks after watching a digital video on a PDA. Outcome measures include participant knowledge of disease, knowledge of medications, and knowledge of adherence behaviors; attitudes toward the video and PDA; self-reported adherence; and practicality of the intervention. Results: Fifty-one English-speaking adults who were initiating or taking medications for the treatment of HIV/AIDS participated in the study. At visit one, statistically significant improvements in knowledge of disease (p <0.005; paired t-test), knowledge of medications (p <0.005; paired t-test), and knowledge of adherence behaviors (p <0.05; ANOVA) were measured after participants watched the PDA-based video. At visit two (4–6 weeks later), statistically significant improvements in self-reported adherence to the medication regimens (p <0.005; paired t-test) were reported. Participants liked the PDA-based video and indicated that it was an appropriate medium for learning, regardless of their baseline literacy skills. The video education process was estimated to take 25min of participant time and was viewed in both private and semi-private locations. Conclusions: Technology-assisted education using a digital video delivered via PDA is a convenient and potentially powerful way to deliver health messages. The intervention was implemented efficiently with participants of a variety of ages and educational levels, and in a range of locations within clinical environments. Additional study of this methodology is warranted. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Medical Informatics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIGITAL video
KW - DIGITAL image processing
KW - POCKET computers
KW - PATIENT education
KW - HEALTH education
KW - MEDICAL informatics
KW - Handheld computers
KW - Literacy
KW - Patient nonadherence
N1 - Accession Number: 27155637; Brock, Tina Penick 1; Email Address: tina.brock@pharmacy.ac.uk Smith, Scott R. 2; Affiliation: 1: The University of London, London, UK 2: The Center for Outcomes & Evidence at the Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Nov2007, Vol. 76 Issue 11/12, p829; Subject Term: DIGITAL video; Subject Term: DIGITAL image processing; Subject Term: POCKET computers; Subject Term: PATIENT education; Subject Term: HEALTH education; Subject Term: MEDICAL informatics; Author-Supplied Keyword: Handheld computers; Author-Supplied Keyword: Literacy; Author-Supplied Keyword: Patient nonadherence; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ijmedinf.2006.09.024
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allread, W. G.
AU - Waters, T. R.
T1 - Interventions to Reduce Low-Back Injury Risk Among Youth Who Perform Feed Handling and Scooping Tasks on Farms.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2007/11//
VL - 13
IS - 4
M3 - Article
SP - 375
EP - 393
SN - 10747583
AB - The article discusses the study that evaluates the low-back injury of young workers in handling farm tasks and feed scooping in the U.S. Findings reveal that feed bag handling reduces the risk of low-back disorder (LBD) by 10 percent as well as the lowering of drop-down flap. It suggests that ergonomic and biomechanical intervention principles should be applied in feed handling and scooping to implement changes in work method. It is believed that education and training of children and adolescents on musculoskeletal disorder could reduce injury risk.
KW - Animal feeding
KW - DISEASES
KW - Diseases
KW - Agricultural laborers
KW - Lumbar pain
KW - Work-related injuries
KW - Musculoskeletal system
KW - RISK factors
KW - Back
KW - Pain
KW - United States
KW - Farming
KW - Feed handling
KW - Feed scooping
KW - Interventions
KW - Musculoskeletal disorders
KW - Spinal loading
KW - Youth
N1 - Accession Number: 27743233; Allread, W. G. 1; Email Address: allread.1@osu.edu; Waters, T. R. 2; Affiliations: 1: Program Director, Institute for Ergonomics, Ohio State University, Columbus, Ohio; 2: Research Engineer, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Nov2007, Vol. 13 Issue 4, p375; Thesaurus Term: Animal feeding; Thesaurus Term: DISEASES; Thesaurus Term: Diseases; Thesaurus Term: Agricultural laborers; Subject Term: Lumbar pain; Subject Term: Work-related injuries; Subject Term: Musculoskeletal system; Subject Term: RISK factors; Subject Term: Back; Subject Term: Pain; Subject: United States; Author-Supplied Keyword: Farming; Author-Supplied Keyword: Feed handling; Author-Supplied Keyword: Feed scooping; Author-Supplied Keyword: Interventions; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Spinal loading; Author-Supplied Keyword: Youth; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; Number of Pages: 19p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McClure, Foster D.
AU - Lee, Jung K.
T1 - Exact One-Tailed 100p% Upper Limits for Future Sample Repeatability Relative Standard Deviations Obtained in Single- and Multilaboratory Repeatability Studies.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2007/11//Nov/Dec2007
VL - 90
IS - 6
M3 - Article
SP - 1701
EP - 1705
PB - AOAC International
SN - 10603271
AB - The article reports on the results of exact one-tailed 100p percent upper limits for future sample repeatability relative standard deviations obtained in single and multilaboratory repeatability studies. A description of the experimental set-up and measurement method is presented. An example of calculations that are proposed for a single-laboratory repeatability study is provided.
KW - STANDARD deviations
KW - ANALYTICAL chemistry
KW - ANALYSIS of variance
KW - CHEMISTRY
KW - STATISTICS
N1 - Accession Number: 28133409; McClure, Foster D. 1; Email Address: fdmc5100@yahoo.com Lee, Jung K. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Defense, Communication and Emergency Response, Division of Public Health and Biostatistics, Biostatistics Branch, 5100 Paint Branch Pkwy, College Park, MD 20740-3835; Source Info: Nov/Dec2007, Vol. 90 Issue 6, p1701; Subject Term: STANDARD deviations; Subject Term: ANALYTICAL chemistry; Subject Term: ANALYSIS of variance; Subject Term: CHEMISTRY; Subject Term: STATISTICS; Number of Pages: 5p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zinnanti, William J.
AU - Lazovic, Jelena
AU - Housman, Cathy
AU - LaNoue, Kathryn
AU - O'Callaghan, James P.
AU - Simpson, Ian
AU - Woontner, Michael
AU - Goodman, Stephen I.
AU - Connor, James R.
AU - Jacobs, Russell E.
AU - Cheng, Keith C.
T1 - Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2007/11//
VL - 117
IS - 11
M3 - journal article
SP - 3258
EP - 3270
SN - 00219738
AB - Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease. Affected children commonly suffer acute brain injury in the context of a catabolic state associated with nonspecific illness. The mechanisms underlying injury and age-dependent susceptibility have been unknown, and lack of a diagnostic marker heralding brain injury has impeded intervention efforts. Using a mouse model of GA-I, we show that pathologic events began in the neuronal compartment while enhanced lysine accumulation in the immature brain allowed increased glutaric acid production resulting in age-dependent injury. Glutamate and GABA depletion correlated with brain glutaric acid accumulation and could be monitored in vivo by proton nuclear magnetic resonance (1H NMR) spectroscopy as a diagnostic marker. Blocking brain lysine uptake reduced glutaric acid levels and brain injury. These findings provide what we believe are new monitoring and treatment strategies that may translate for use in human GA-I. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASE susceptibility
KW - NUCLEAR magnetic resonance
KW - HUNTINGTON'S chorea
KW - AMINO acid neurotransmitters
KW - NUCLEAR quadrupole resonance
KW - GLUCOSE
KW - LYSINE
KW - ARGININE
KW - GLUCOSE metabolism
KW - ARGININE metabolism
KW - LYSINE metabolism
KW - TRYPTOPHAN metabolism
KW - GLUTAMIC acid metabolism
KW - BRAIN diseases
KW - AGING
KW - AMINO acid metabolism disorders
KW - ANIMAL experimentation
KW - BIOLOGICAL models
KW - COMPARATIVE studies
KW - DIET
KW - GABA
KW - RESEARCH -- Methodology
KW - MEDICAL cooperation
KW - INBORN errors of metabolism
KW - MICE
KW - MITOCHONDRIA
KW - NEURONS
KW - NUCLEAR magnetic resonance spectroscopy
KW - OXIDOREDUCTASES
KW - RESEARCH
KW - EVALUATION -- Research
KW - ACYCLIC acids
KW - THERAPEUTIC use
N1 - Accession Number: 27477514; Zinnanti, William J. 1; Email Address: wjz105@psu.edu Lazovic, Jelena 2 Housman, Cathy 3 LaNoue, Kathryn 4 O'Callaghan, James P. 5 Simpson, Ian 6 Woontner, Michael 7 Goodman, Stephen I. 7 Connor, James R. 8 Jacobs, Russell E. 2 Cheng, Keith C. 1; Email Address: kcheng76@gmail.com; Affiliation: 1: Jake Gittlen Cancer Research Foundation, Department of Pathology, Department of Biochemistry & Molecular Biology, and Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA 2: Beckman Institute, California Institute of Technology, Pasadena, California, USA 3: Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA 4: Department of Cellular & Molecular Physiology and Department of Biochemistry, Penn State College of Medicine, Hershey, Pennsylvania, USA 5: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 6: Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA 7: Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA 8: Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania, USA; Source Info: Nov2007, Vol. 117 Issue 11, p3258; Subject Term: DISEASE susceptibility; Subject Term: NUCLEAR magnetic resonance; Subject Term: HUNTINGTON'S chorea; Subject Term: AMINO acid neurotransmitters; Subject Term: NUCLEAR quadrupole resonance; Subject Term: GLUCOSE; Subject Term: LYSINE; Subject Term: ARGININE; Subject Term: GLUCOSE metabolism; Subject Term: ARGININE metabolism; Subject Term: LYSINE metabolism; Subject Term: TRYPTOPHAN metabolism; Subject Term: GLUTAMIC acid metabolism; Subject Term: BRAIN diseases; Subject Term: AGING; Subject Term: AMINO acid metabolism disorders; Subject Term: ANIMAL experimentation; Subject Term: BIOLOGICAL models; Subject Term: COMPARATIVE studies; Subject Term: DIET; Subject Term: GABA; Subject Term: RESEARCH -- Methodology; Subject Term: MEDICAL cooperation; Subject Term: INBORN errors of metabolism; Subject Term: MICE; Subject Term: MITOCHONDRIA; Subject Term: NEURONS; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: OXIDOREDUCTASES; Subject Term: RESEARCH; Subject Term: EVALUATION -- Research; Subject Term: ACYCLIC acids; Subject Term: THERAPEUTIC use; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 2 Color Photographs, 1 Black and White Photograph, 2 Diagrams, 5 Graphs; Document Type: journal article
L3 - 10.1172/JCI31617
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Sahn, David E.
AU - Younger, Stephen D.
T1 - The joint demand for health care, leisure, and commodities: Implications for health care finance and access in Vietnam.
JO - Journal of Development Studies
JF - Journal of Development Studies
Y1 - 2007/11//
VL - 43
IS - 8
M3 - Article
SP - 1475
EP - 1500
PB - Routledge
SN - 00220388
AB - This paper explores linkages between the demand for health care providers and the consumption of food, non-food goods, and leisure in Vietnam, using a mixed continuous/discrete dependent variable model. Cross-price elasticities calculated from the model suggest there are strong substitution effects between health care, leisure, and certain commodities. The model allows us to explore the implications of replacing user fees with alternative forms of health care finance, such as commodity taxes. In particular, the results suggest financing public health care services with a non-food sales tax rather than user fees would be more progressive and would improve access to care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Development Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Finance
KW - HEALTH services accessibility
KW - ELASTICITY (Economics)
KW - USER charges
KW - LEISURE
KW - VIETNAM
N1 - Accession Number: 27753960; Meyerhoefer, Chad D. 1; Email Address: chad.meyerhoefer@ahrq.hhs.gov Sahn, David E. 2 Younger, Stephen D. 2; Affiliation: 1: Agency for Healthcare Research and Quality, USA 2: Cornell University, USA; Source Info: Nov2007, Vol. 43 Issue 8, p1475; Subject Term: MEDICAL care -- Finance; Subject Term: HEALTH services accessibility; Subject Term: ELASTICITY (Economics); Subject Term: USER charges; Subject Term: LEISURE; Subject Term: VIETNAM; Number of Pages: 26p; Illustrations: 11 Charts; Document Type: Article
L3 - 10.1080/00220380701611527
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - A. Dale Marcy
AU - Pamela L. Drake
T1 - Development of a field method for measuring manganese in welding fume.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2007/11//
VL - 9
IS - 11
M3 - Article
SP - 1199
EP - 1204
SN - 14640325
AB - Workers who perform routine welding tasks are potentially exposed to fume that may contain manganese. Manganese may cause respiratory problems and is implicated in causing the occurrence of Parkinson-like symptoms. In this study, a field colorimetric method for extracting and measuring manganese in welding fume was developed. The method uses ultrasonic extraction with an acidic hydrogen peroxide solution to extract welding fume collected on polyvinyl chloride filters. Commercially available pre-packaged reagents are used to produce a colored solution, created by a reaction of manganese(ii) with 1-(2-pyridylazo)-2-naphthol. Absorbance measurements are then made using a portable spectrophotometer. The method detection limit and limit of quantification (LOQ) were 5.2 μg filter−1 and 17 μg filter−1, respectively, with a dynamic range up to 400 μg filter−1. When the results are above the LOQ for the colorimetric method, the manganese masses are equivalent to those measured by the International Organization for Standardization Method 15202-2, which employs a strong acid digestion and analysis using inductively coupled plasma-optical emission spectrometry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Welding
KW - Sealing (Technology)
KW - Metalwork
KW - Ironwork
N1 - Accession Number: 27299808; A. Dale Marcy 1,2; Pamela L. Drake 1; Affiliations: 1: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave Spokane USA pdrake@cdc.gov; 2: North Idaho College, 1000 W. Garden Ave Coeur d’Alene USA.; Issue Info: Nov2007, Vol. 9 Issue 11, p1199; Subject Term: Welding; Subject Term: Sealing (Technology); Subject Term: Metalwork; Subject Term: Ironwork; NAICS/Industry Codes: 332111 Iron and Steel Forging; NAICS/Industry Codes: 238190 Other Foundation, Structure, and Building Exterior Contractors; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martin Harper
AU - Bruce Pacolay
AU - Patrick Hintz
AU - David L. Bartley
AU - James E. Slaven
AU - Michael E. Andrew
T1 - Portable XRF analysis of occupational air filter samples from different workplaces using different samplers: final results, summary and conclusionsElectronic supplementary information (ESI) available: Appendix 1—low concentrations: limit on the limit of quantitation. See DOI: 10.1039/b710591f
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2007/11//
VL - 9
IS - 11
M3 - Article
SP - 1263
EP - 1270
SN - 14640325
AB - This paper concludes a five-year program on research into the use of a portable X-ray fluorescence (XRF) analyzer for analyzing lead in air sampling filters from different industrial environments, including mining, manufacturing and recycling. The results from four of these environments have already been reported. The results from two additional metal processes are presented here. At both of these sites, lead was a minor component of the total airborne metals and interferences from other elements were minimal. Nevertheless, only results from the three sites where lead was the most abundant metal were used in the overall calculation of method accuracy. The XRF analyzer was used to interrogate the filters, which were then subjected to acid digestion and analysis by inductively-coupled plasma optical-emission spectroscopy (ICP-OES). The filter samples were collected using different filter-holders or “samplers” where the size (diameter), depth and homogeneity of aerosol deposit varied from sampler to sampler. The aerosol collection efficiencies of the samplers were expected to differ, especially for larger particles. The distribution of particles once having entered the sampler was also expected to differ between samplers. Samplers were paired to allow the between-sampler variability to be addressed, and, in some cases, internal sampler wall deposits were evaluated and compared to the filter catch. It was found, rather surprisingly, that analysis of the filter deposits (by ICP-OES) of all the samplers gave equivalent results. It was also found that deposits on some of the sampler walls, which in some protocols are considered part of the sample, could be significant in comparison to the filter deposit. If it is concluded that wall-deposits should be analyzed, then XRF analysis of the filter can only give a minimum estimate of the concentration. Techniques for the statistical analysis of field data were also developed as part of this program and have been reported elsewhere. The results, based on data from the three workplaces where lead was the major element present in the samples, are summarized here. A limit of detection and a limit of quantitation are provided. Analysis of some samples using a second analyzer with a different X-ray source technology indicated reasonable agreement for some metals (but this was not evaluated for lead). Provided it is only necessary to analyze the filters, most personal samplers will provide acceptable results when used with portable XRF analysis for lead around applicable limit values. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air filters
KW - Air -- Purification
KW - Work environment
KW - Atomic spectroscopy
N1 - Accession Number: 27299818; Martin Harper 1; Bruce Pacolay 1; Patrick Hintz 2; David L. Bartley 3; James E. Slaven 4; Michael E. Andrew 4; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health1095 Willowdale Rd. MS-3030 Morgantown, WV USA; 2: Spokane Research Laboratory, National Institute for Occupational Safety and Health315 E. Montgomery Ave. Spokane, WA USA; 3: Guest Researcher, National Institute for Occupational Safety and Health4676 Columbia Parkway Cincinnati, OH USA; 4: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health1095 Willowdale Rd. MS-4020 Morgantown, WV USA; Issue Info: Nov2007, Vol. 9 Issue 11, p1263; Thesaurus Term: Air filters; Thesaurus Term: Air -- Purification; Subject Term: Work environment; Subject Term: Atomic spectroscopy; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parveen, Salina
AU - Taabodi, Maryam
AU - Schwarz, Jurgen G.
AU - Oscar, Thomas P.
AU - Harter-Dennis, Jeannine
AU - White, David G.
T1 - Prevalence and Antimicrobial Resistance of Salmonella Recovered from Processed Poultry.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/11//
VL - 70
IS - 11
M3 - Article
SP - 2466
EP - 2472
SN - 0362028X
AB - This study was conducted to determine the prevalence and antimicrobial resistance of Salmonella isolates recovered from processed poultry. Four hundred eighty pre- and postchill whole broiler chicken carcasses were collected from a poultry processing plant between July 2004 and June 2005. Water samples also were collected at the entrance and exit of the chiller. After preenrichment, carcass and water samples were analyzed for the presence of Salmonella using the automated BAX system followed by traditional culture methods. The proportions of pre- and postchill carcasses that were positive for Salmonella were 88.4 and 84.1%, respectively. Ninety-two percent of water samples collected at the entrance of the chiller were positive for Salmonella, but all exit samples were negative. There was no significant difference in the prevalence of Salmonella between pre- and postchill carcasses (P > 0.05). Salmonella isolates recovered were serotyped and tested for susceptibility to antimicrobials. Thirteen serotypes were identified; the most common were Salmonella Kentucky (59.5%) and Salmonella Typhimurium (17.8%). Three hundred thirty-nine (79.8%) of the isolates were resistant to at least one antimicrobial, and 53.4% were resistant to three or more antimicrobials. Resistance was most often observed to tetracycline (73.4% of isolates), ampicillin 52.9%), amoxicillin-clavulanic acid (52%), ceftiofur (51.7%), streptomycin (35.2%), and sulfisoxazole (21.8%). These results indicate the high prevalence of Salmonella contamination in whole broiler carcasses, and a large number of these Salmonella isolates were resistant to commonly used antimicrobials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Food contamination
KW - Salmonella infections in poultry
KW - Microbial sensitivity tests
KW - Poultry -- Processing
KW - Poultry processing plants
N1 - Accession Number: 27584810; Parveen, Salina 1; Email Address: sparveen@umes.edu; Taabodi, Maryam 1; Schwarz, Jurgen G. 1; Oscar, Thomas P. 2; Harter-Dennis, Jeannine 1; White, David G. 3; Affiliations: 1: Food Science and Technology Program, Department of Agriculture, University of Maryland Eastern Shore, Princess Anne, Maryland 21853; 2: U.S. Department of Agriculture, Agricultural Research Service, Princess Anne, Maryland 21853; 3: Food and Drug Administration, Center for Veterinary, Medicine, Laurel, Maryland 20708, USA; Issue Info: Nov2007, Vol. 70 Issue 11, p2466; Thesaurus Term: Anti-infective agents; Thesaurus Term: Food contamination; Subject Term: Salmonella infections in poultry; Subject Term: Microbial sensitivity tests; Subject Term: Poultry -- Processing; Subject Term: Poultry processing plants; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Abou-Zeid, K. A.
AU - Yoon, K. S.
AU - Oscar, T. P.
AU - Schwarz, J. G.
AU - Hashem, F. M.
AU - Whiting, R. C.
T1 - Survival and Growth of Listeria monocytogenes in Broth as a Function of Temperature, pH, and Potassium Lactate and Sodium Diacetate Concentrations.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/11//
VL - 70
IS - 11
M3 - Article
SP - 2620
EP - 2625
SN - 0362028X
AB - The objective of this study was to determine the antimicrobial effect of a combination of potassium lactate and sodium diacetate (0, 1.8, 3, and 4.5%: PURASAL P Opti.Form 4, 60% solution) on the survival and growth of Listeria monocytogenes Scott A in pH-adjusted broth (5.5, 6.0, 6.5, and 7.0) stored at 4, 10, 17, 24, 30, and 37°C. Appropriate dilutions of broth were enumerated by spiral plating on tryptose agar and counted with an automated colony counter. Growth data were iteratively fit, using nonlinear regression analysis to a three-phase linear model, using GraphPad PRISM. At pH 5.5, the combination of lactate-diacetate fully inhibited (P < 0.001) the growth of L. monocytogenes at all four levels and six temperatures. At pH 6.0, addition of 1.8% lactate-diacetate reduced (P < 0.001) the specific growth rate of L. monocytogenes and increased lag time; however, 3 and 4.5% completely inhibited the growth at the six temperatures studied. Efficacy of the lactate-diacetate mixture was decreased as pH increased and incubation temperature increased. Thus, at pH 6.5, at least 3% was required to retard (P < 0.001) the growth of L. monocytogenes in broth. There was a limited effect of the lactate-diacetate level on the specific growth rate of the pathogen at pH 7.0. However, 1.8 and 3% significantly lengthened the lag time at 4 and 10°C. These results suggest that 1.8% of lactate-diacetate mixture can be used as a substantial hurdle to the growth of L. monocytogenes when refrigerated temperatures are maintained for products with pH less than 6.5. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Bacterial growth
KW - Listeria monocytogenes
KW - Regression analysis
KW - Lactates
KW - Acetates
N1 - Accession Number: 27584833; Abou-Zeid, K. A. 1,2; Yoon, K. S. 1,3; Email Address: ksyoon@khu.ac.kr; Oscar, T. P. 4; Schwarz, J. G. 1; Hashem, F. M. 1; Whiting, R. C. 5; Affiliations: 1: Center for Food Science and Technology, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, USA; 2: Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York 14853, USA; 3: Department of Food and Nutrition, Kyung Hee University, Seoul, Republic of Korea 130-701; 4: Microbial Food Safety Research Unit, U.S. Department of Agriculture, Agricultural Research Service, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, USA; 5: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Nov2007, Vol. 70 Issue 11, p2620; Thesaurus Term: Anti-infective agents; Thesaurus Term: Bacterial growth; Subject Term: Listeria monocytogenes; Subject Term: Regression analysis; Subject Term: Lactates; Subject Term: Acetates; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Darnell, Miriam E. R.
AU - Plant, Ewan P.
AU - Watanabe, Hisayoshi
AU - Byrum, Russ
AU - St. Claire, Marisa
AU - Ward, Jerrold M.
AU - Taylor, Deborah R.
T1 - Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2007/11//11/1/2007
VL - 196
IS - 9
M3 - Article
SP - 1329
EP - 1338
SN - 00221899
AB - Background. Development of vaccines to prevent severe acute respiratory syndrome (SARS) is limited by the lack of well-characterized animal models. Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis. Methods. We evaluated the humoral immune response and pathological end points in ferrets challenged with the Urbani strain of SARS-associated coronavirus (SARS-CoV) after having received formalin-inactivated whole-virus vaccine or mock vaccine. Results. Humoral responses were observed in ferrets that received an inactivated virus vaccine. Histopathological findings in lungs showed that infection of ferrets produced residual lung lesions not seen in both mock and vaccinated ferrets. SARS-CoV infection demonstrated bronchial and bronchiolar hyperplasia and perivascular cuffing in ferret lung tissue, as seen previously in infected mice. No evidence of enhanced disease was observed in any of the ferrets. All of the ferrets cleared the virus by day 14, 1 week earlier if vaccinated. Conclusions. The vaccine provided mild immune protection to the ferrets after challenge; however, there was no evidence of enhanced liver or lung disease induced by the inactivated whole-virus vaccine. The ferret may provide another useful model for evaluating SARS vaccine safety and efficacy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES -- Biotechnology
KW - PREVENTIVE medicine
KW - VIRAL vaccines
KW - ADULT respiratory distress syndrome
KW - LUNG diseases
KW - SARS (Disease)
KW - COMMUNICABLE diseases
KW - CORONAVIRUS diseases
KW - RESPIRATORY infections
KW - RESPIRATORY diseases
N1 - Accession Number: 27277044; Darnell, Miriam E. R. 1 Plant, Ewan P. 1 Watanabe, Hisayoshi 2 Byrum, Russ 3 St. Claire, Marisa 3 Ward, Jerrold M. 4 Taylor, Deborah R. 1; Email Address: Deborah.Taylor@FDA.HHS.gov; Affiliation: 1: Laboratory of Hepatitis and Related Emerging Agents, Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review 2: Laboratory of Hepatitis Viruses, Center for Biologics Evaluation and Research, US Food and Drug Administration 3: Bioqual, Inc., Rockville, Maryland 4: Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda; Source Info: 11/1/2007, Vol. 196 Issue 9, p1329; Subject Term: VACCINES -- Biotechnology; Subject Term: PREVENTIVE medicine; Subject Term: VIRAL vaccines; Subject Term: ADULT respiratory distress syndrome; Subject Term: LUNG diseases; Subject Term: SARS (Disease); Subject Term: COMMUNICABLE diseases; Subject Term: CORONAVIRUS diseases; Subject Term: RESPIRATORY infections; Subject Term: RESPIRATORY diseases; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1086/522431
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Birdsey, Jan
AU - Alterman, Toni
AU - Petersen, Martin R.
T1 - Race, Occupation, and Lung Cancer: Detecting Disparities With Death Certificate Data.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2007/11//
VL - 49
IS - 11
M3 - Article
SP - 1257
EP - 1263
SN - 10762752
AB - This article presents a study which determines whether the analysis of death certificate data would reveal the same relationship among race, occupational exposure, and lung cancer mortality observed by a large cohort study. The result of the study shows that black men were at increased risk for lung cancer mortality when associated with white men among the 4,668 oven workers. The findings confirmed a previously demonstrated association among exposure to carcinogenic coke oven emissions, lung cancer mortality, and race.
KW - LUNGS -- Cancer
KW - CANCER patients
KW - MORTALITY
KW - CANCER -- Mortality
KW - CANCER
KW - BLACKS
KW - WHITES
KW - ETHNOLOGY
KW - RACE
N1 - Accession Number: 27756369; Birdsey, Jan 1; Email Address: JBirdsey@cdc.gov Alterman, Toni 1 Petersen, Martin R. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH; Source Info: Nov2007, Vol. 49 Issue 11, p1257; Subject Term: LUNGS -- Cancer; Subject Term: CANCER patients; Subject Term: MORTALITY; Subject Term: CANCER -- Mortality; Subject Term: CANCER; Subject Term: BLACKS; Subject Term: WHITES; Subject Term: ETHNOLOGY; Subject Term: RACE; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1097/JOM.0b013e318154c094
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cook, Judith A.
AU - Razzano, Lisa A.
AU - Burke-Miller, Jane K.
AU - Blyler, Crystal R.
AU - Leff, H. Stephen
AU - Mueser, Kim T.
AU - Gold, Paul B.
AU - Goldberg, Richard W.
AU - Shafer, Michael S.
AU - Onken, Steven J.
AU - McFarlane, William R.
AU - Donegan, Kate
AU - Carey, Martha Ann
AU - Kaufmann, Caroline
AU - Grey, Dennis D.
T1 - Effects of co-occurring disorders on employment outcomes in a multisite randomized study of supported employment for people with severe mental illness.
JO - Journal of Rehabilitation Research & Development
JF - Journal of Rehabilitation Research & Development
Y1 - 2007/11//
VL - 44
IS - 6
M3 - Article
SP - 837
EP - 850
PB - VA Prosthetics Research & Development Center
SN - 07487711
AB - Effects of co-occurring disorders on work outcomes were explored among individuals with severe mental illness who were participating in a multisite randomized study of supported employment. At seven sites, 1,273 people were randomly assigned to an experimental supported employment program or a control condition and followed for 2 years. Multivariate regression analysis examined work outcomes including earnings, hours worked, and competitive employment, as well as whether psychiatric disability was disclosed to coworkers and supervisors. Individuals with any comorbidity had lower earnings and were less likely to work competitively. Those with physical comorbidities had lower earnings, worked fewer hours, and were less likely to work competitively. Disclosure was more likely among those with both cognitive and physical comorbidities, as well as those with learning disabilities. Competitive employment was less likely among those with intellectual disability, visual impairment, and human immunodeficiency virus/acquired immunodeficiency syndrome. The experimental condition was positively related to all outcomes except disclosure. The results suggest that, with some exceptions, comorbidities affect employment outcomes, requiring tailored services and supports to promote vocational success. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Rehabilitation Research & Development is the property of VA Prosthetics Research & Development Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTALLY ill -- Employment
KW - PEOPLE with mental disabilities
KW - PEOPLE with disabilities -- Vocational guidance
KW - MENTALLY ill -- Rehabilitation
KW - EMPLOYMENT
KW - co-occuring disorders
KW - comorbidities
KW - employment
KW - evidence-based practice
KW - mental illness
KW - psychiatric disability
KW - recovery
KW - substance use
KW - supported employment
KW - vocational rehabilitation
N1 - Accession Number: 31955206; Cook, Judith A. 1; Email Address: cook@ripco.com Razzano, Lisa A. 1 Burke-Miller, Jane K. 1 Blyler, Crystal R. 2 Leff, H. Stephen 3 Mueser, Kim T. 4 Gold, Paul B. 5 Goldberg, Richard W. 6 Shafer, Michael S. 7 Onken, Steven J. 8 McFarlane, William R. 9 Donegan, Kate 10 Carey, Martha Ann 11 Kaufmann, Caroline 12 Grey, Dennis D. 1; Affiliation: 1: University of Illinois, Chicago, IL. 2: Center for Mental Health Services, Rockville, MD. 3: Human Services Research Institute, Cambridge, MA. 4: Dartmouth University, Concord, NH. 5: Medical University of South Carolina, Charleston, SC. 6: University of Maryland, Baltimore, MD. 7: Arizona State University, Phoenix, AZ. 8: University of Hawaii at Manoa, Honolulu, HI. 9: Maine Medical Center Portland, ME. 10: Matrix Center, Horizon House, Inc, Philadelphia, PA. 11: Azusa Pacific University, Azusa, CA. 12: Consumer Research and Advocacy, Clearwater FL.; Source Info: 2007, Vol. 44 Issue 6, p837; Subject Term: MENTALLY ill -- Employment; Subject Term: PEOPLE with mental disabilities; Subject Term: PEOPLE with disabilities -- Vocational guidance; Subject Term: MENTALLY ill -- Rehabilitation; Subject Term: EMPLOYMENT; Author-Supplied Keyword: co-occuring disorders; Author-Supplied Keyword: comorbidities; Author-Supplied Keyword: employment; Author-Supplied Keyword: evidence-based practice; Author-Supplied Keyword: mental illness; Author-Supplied Keyword: psychiatric disability; Author-Supplied Keyword: recovery; Author-Supplied Keyword: substance use; Author-Supplied Keyword: supported employment; Author-Supplied Keyword: vocational rehabilitation; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 13p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soneson, Joshua E.
AU - Myers, Matthew R.
T1 - Gaussian representation of high-intensity focused ultrasound beams.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2007/11//
VL - 122
IS - 5
M3 - Article
SP - 2526
EP - 2531
SN - 00014966
AB - A method for fast numerical simulation of high-intensity focused ultrasound beams is derived. The method is based on the frequency-domain representation of the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation, and assumes for each harmonic a Gaussian transverse pressure distribution at all distances from the transducer face. The beamwidths of the harmonics are constrained to vary inversely with the square root of the harmonic number, and as such this method may be viewed as an extension of a quasilinear approximation. The technique is capable of determining pressure or intensity fields of moderately nonlinear high-intensity focused ultrasound beams in water or biological tissue, usually requiring less than a minute of computer time on a modern workstation. Moreover, this method is particularly well suited to high-gain simulations since, unlike traditional finite-difference methods, it is not subject to resolution limitations in the transverse direction. Results are shown to be in reasonable agreement with numerical solutions of the full KZK equation in both tissue and water for moderately nonlinear beams. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAUSSIAN distribution
KW - GAUSSIAN beams
KW - ULTRASONICS
KW - ULTRASONIC waves
KW - SOUND waves
KW - ACOUSTICAL engineering
N1 - Accession Number: 28154433; Soneson, Joshua E. 1; Email Address: joshua.soneson@fda.hhs.gov Myers, Matthew R. 1; Email Address: matthew.myers@fdsa.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Nov2007, Vol. 122 Issue 5, p2526; Subject Term: GAUSSIAN distribution; Subject Term: GAUSSIAN beams; Subject Term: ULTRASONICS; Subject Term: ULTRASONIC waves; Subject Term: SOUND waves; Subject Term: ACOUSTICAL engineering; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1121/1.2783124
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baron, Paul A.
AU - Estill, C. F.
AU - Beard, J. K.
AU - Hein, M. J.
AU - Larsen, L.
T1 - Bacterial endospore inactivation caused by outgassing of vapourous hydrogen peroxide from polymethyl methacrylate (Plexiglas®).
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2007/11//
VL - 45
IS - 5
M3 - Article
SP - 485
EP - 490
PB - Wiley-Blackwell
SN - 02668254
AB - Aims: To investigate the cause and to eliminate the inactivation of Bacillus anthracis strain Sterne spores settled onto agar and stainless steel surfaces in plastic holders. Methods and Results: In an experimental chamber in which spores settled onto sampling surfaces, vapourous hydrogen peroxide (VHP) was used for decontamination between experiments. It was demonstrated that hydrogen peroxide (H2O2) absorbed into plastic (Plexiglas®) surfaces and could outgas in the sample holders. Further experiments demonstrated that H2O2 was released from Plexiglas® sample holders in sufficient quantity to inactivate spores. High temperature degassing (30–35°C) for several days or aluminum coating of the surfaces were two remedies found to be effective in preventing inadvertent spore inactivation. Conclusions: H2O2 can be absorbed into plastic and released after an extended period of time (weeks), allowing a sufficient concentration to accumulate in small volumes to inactivate spores. Outgassing the plastic or coating the surface with an impermeable layer are potential solutions to reduce spore inactivation. Significance and Impact of the Study: Many studies with bacilli and other organisms are carried out using small plastic containers that may have been sterilized using H2O2 or other agents. This study presents a cautionary note to ensure elimination of H2O2 or other sterilizing agents to prevent spurious results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Letters in Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS inactivation
KW - OUTGASSING (Low pressure environments)
KW - HYDROGEN peroxide
KW - POLYMETHYLMETHACRYLATE
KW - BACILLUS anthracis
KW - AGAR
KW - STAINLESS steel
KW - PLASTIC containers
KW - DECONTAMINATION (From gases, chemicals, etc.)
KW - MICROBIOLOGY
KW - Bacillus anthracis
KW - decontamination
KW - hydrogen peroxide
KW - outgassing
KW - Plexiglas
KW - spore
KW - sterilization
KW - VHP
N1 - Accession Number: 27161622; Baron, Paul A. 1; Email Address: pbaron@cdc.gov Estill, C. F. 1 Beard, J. K. 2 Hein, M. J. 1 Larsen, L. 2; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA 2: U.S. Army Dugway Proving Ground, Dugway, UT, USA; Source Info: Nov2007, Vol. 45 Issue 5, p485; Subject Term: VIRUS inactivation; Subject Term: OUTGASSING (Low pressure environments); Subject Term: HYDROGEN peroxide; Subject Term: POLYMETHYLMETHACRYLATE; Subject Term: BACILLUS anthracis; Subject Term: AGAR; Subject Term: STAINLESS steel; Subject Term: PLASTIC containers; Subject Term: DECONTAMINATION (From gases, chemicals, etc.); Subject Term: MICROBIOLOGY; Author-Supplied Keyword: Bacillus anthracis; Author-Supplied Keyword: decontamination; Author-Supplied Keyword: hydrogen peroxide; Author-Supplied Keyword: outgassing; Author-Supplied Keyword: Plexiglas; Author-Supplied Keyword: spore; Author-Supplied Keyword: sterilization; Author-Supplied Keyword: VHP; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 326198 All other plastic product manufacturing; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1472-765X.2007.02209.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105829330
T1 - Explaining racial and ethnic differences in children's use and stimulant medications.
AU - Hudson JL
AU - Miller GE
AU - Kirby JB
Y1 - 2007/11//2007 Nov
N1 - Accession Number: 105829330. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Attention Deficit Hyperactivity Disorder -- Drug Therapy
KW - Attention Deficit Hyperactivity Disorder -- Ethnology
KW - Central Nervous System Stimulants -- Therapeutic Use
KW - Adolescence
KW - Central Nervous System Stimulants -- Administration and Dosage
KW - Child
KW - Child, Preschool
KW - Drug Utilization
KW - Female
KW - Insurance Coverage
KW - Insurance, Health
KW - Male
KW - Mental Health
KW - Socioeconomic Factors
SP - 1068
EP - 1075
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 45
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: To document and explain racial/ethnic differences in the use of stimulant drugs among US children. DATA AND METHODS: We use a nationally representative sample of children ages 5-17 years old from the Medical Expenditure Panel Survey (MEPS) for the years 2000-2002. We estimate race-specific means and regressions to highlight differences across groups in individual/family characteristics that may affect stimulant use and differences in responses to these characteristics. Then, we use Oaxaca-Blinder decomposition methods to quantify the portion of differential use explained by differences in individual/family characteristics. Finally, we use pooled regressions with race/ethnicity interactions to formally test the hypothesis that responses to perceived mental health and behavioral problems vary across groups. RESULTS: White children are about twice as likely to use stimulants as either Hispanic or Black children. Differences in individual/family characteristics account for about 25% of the difference between whites and Hispanics, but for none of the difference between whites and blacks. Pooled regressions show that racial/ethnic gaps in stimulant use persist among children with otherwise similar reported mental health conditions. CONCLUSIONS: Our finding that the majority of racial/ethnic differences in children's stimulant use is explained by differences in responses to individual/family characteristics highlights the importance of further research to examine the reasons for these differences. It is striking that children with otherwise similar reports of mental health problems have such different outcomes in terms of stimulant use. Potential explanations range from discrimination to cultural differences by race/ethnicity or community.
SN - 0025-7079
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; jhudson@ahrq.gov
U2 - PMID: 18049347.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Badano, Aldo
AU - Kyprianou, Iacovos S.
AU - Jennings, Robert J.
AU - Sempau, Josep
T1 - Anisotropic imaging performance in breast tomosynthesis.
JO - Medical Physics
JF - Medical Physics
Y1 - 2007/11//
VL - 34
IS - 11
M3 - Article
SP - 4076
EP - 4091
SN - 00942405
AB - We describe the anisotropy in imaging performance caused by oblique x-ray incidence in indirect detectors for breast tomosynthesis based on columnar scintillator screens. We use MANTIS, a freely available combined x-ray, electron, and optical Monte Carlo transport package which models the indirect detection processes in columnar screens, interaction by interaction. The code has been previously validated against published optical distributions. In this article, initial validation results are provided concerning the blur for particular designs of phosphor screens for which some details with respect to the columnar geometry are available from scanning electron microscopy. The polyenergetic x-ray spectrum utilized comes from a database of experimental data for three different anode/filter/kVp combinations: Mo/Mo at 28 kVp, Rh/Rh at 28 kVp, and W/Al at 42 kVp. The x-ray spectra were then filtered with breast tissue (3, 4, and 6 cm thickness), compression paddle, and support base, according to the oblique paths determined by the incidence angle. The composition of the breast tissue was 50%/50% adipose/glandular tissue mass ratio. Results are reported on the pulse-height statistics of the light output and on spatial blur, expressed as the response of the detector to a pencil beam with a certain incidence angle. Results suggest that the response is nonsymmetrical and that the resolution properties of a tomosynthesis system vary significantly with the angle of x-ray incidence. In contrast, it is found that the noise due to the variability in the number of light photons detected per primary x-ray interaction changes only a few percent. The anisotropy in the response is not less in screens with absorptive backings while the noise introduced by variations in the depth-dependent light output and optical transport is larger. The results suggest that anisotropic imaging performance across the detector area can be incorporated into reconstruction algorithms for improving the image quality of breast tomosynthesis. This study also demonstrates that the assessment of image quality of breast tomosynthesis systems requires a more complete description of the detector response beyond local, center measurements of resolution and noise that assume some degree of symmetry in the detector performance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANISOTROPY
KW - DIAGNOSTIC imaging
KW - MAMMOGRAMS
KW - X-rays
KW - MONTE Carlo method
KW - ALGORITHMS
KW - cesium iodide
KW - digital imaging
KW - Monte Carlo simulation
KW - phosphor screen
KW - point response function
KW - Swank factor
N1 - Accession Number: 27371134; Badano, Aldo 1 Kyprianou, Iacovos S. 1 Jennings, Robert J. 1 Sempau, Josep 2; Affiliation: 1: CDRH/NIBIB Laboratory for the Analysis of Medical Imaging Systems, Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993 2: Institut de Técniques Energétiques, Universitat Politécnica de Catalunya, Diagonal 647, 08028 Barcelona, Spain; Source Info: Nov2007, Vol. 34 Issue 11, p4076; Subject Term: ANISOTROPY; Subject Term: DIAGNOSTIC imaging; Subject Term: MAMMOGRAMS; Subject Term: X-rays; Subject Term: MONTE Carlo method; Subject Term: ALGORITHMS; Author-Supplied Keyword: cesium iodide; Author-Supplied Keyword: digital imaging; Author-Supplied Keyword: Monte Carlo simulation; Author-Supplied Keyword: phosphor screen; Author-Supplied Keyword: point response function; Author-Supplied Keyword: Swank factor; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 16p; Illustrations: 10 Color Photographs, 4 Diagrams, 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1118/1.2779943
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105923268
T1 - Device safety. Danger: beware of unretrieved device fragments.
AU - Fischer RA
Y1 - 2007/11//
N1 - Accession Number: 105923268. Language: English. Entry Date: 20080111. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 7600137.
KW - Equipment Failure
KW - Equipment Safety
KW - Foreign Bodies -- Complications
KW - Foreign Bodies -- Etiology
KW - Heart Catheterization -- Equipment and Supplies
KW - Incident Reports
SP - 17
EP - 17
JO - Nursing
JF - Nursing
JA - NURSING
VL - 37
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Anesthesia and central venous catheter device nurse-consultant, Center for Devices and Radiological Health.
U2 - PMID: 17968245.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Obesity, White Blood Cell Counts, and Platelet Counts among Police Officers.
AU - Charles, Luenda E.
AU - Fekedulegn, Desta
AU - McCall, Terika
AU - Burchfiel, Cecil M.
AU - Andrew, Michael E.
AU - Violanti, John M.
JO - Obesity (19307381)
JF - Obesity (19307381)
Y1 - 2007/11//
VL - 15
IS - 11
SP - 2846
EP - 2854
SN - 19307381
N1 - Accession Number: 28088242; Author: Charles, Luenda E.: 1 email: lcharles@cdc.gov. Author: Fekedulegn, Desta: 1 Author: McCall, Terika: 1 Author: Burchfiel, Cecil M.: 1 Author: Andrew, Michael E.: 1 Author: Violanti, John M.: 2 ; Author Affiliation: 1 Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia: 2 School of Public Health and Health Professions, Department of Social and Preventive Medicine, State University of New York, Buffalo, Buffalo, New York; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20161115
N2 - This article discusses findings of a study which determined the association between several obesity indices and hematological parameters among police officers in New York City. Examples of indices include body mass index, waist circumference, waist-to-hip and waist-to-height ratios and abdominal height. Before and after adjustment for smoking, race and physical activity, a non-significant step-wise trend was observed between abdominal height and mean WBC counts.
KW - *OBESITY
KW - *METABOLIC disorders
KW - *HEMATOLOGY
KW - *BODY mass index
KW - *LEUCOCYTES
KW - NEW York (N.Y.)
KW - NEW York (State)
KW - adiposity
KW - BMI
KW - central obesity
KW - epidemiology
KW - hematology
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 105755518
T1 - Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma.
AU - Ning Y
AU - He K
AU - Dagher R
AU - Sridhara R
AU - Farrell AT
AU - Justice R
AU - Pazdur R
Y1 - 2007/11//
N1 - Accession Number: 105755518. Language: English. Entry Date: 20080704. Revision Date: 20150711. Publication Type: Journal Article; CEU; clinical trial; research; tables/charts. Commentary: Buadi FK, Rajkumar SV. The Ning/He/Dagher et al article reviewed. Anthracyclines survive targetted therapy. (ONCOLOGY (08909091)) Nov2007; 21 (12): 1516-1518; Richardson PG, Mitsiades CS, Anderson KC. The Ning/He/Dagher et al article reviewed. Continued progress in treatment options for multiple myeloma: from past to present and future. (ONCOLOGY (08909091)) Nov2007; 21 (12): 1511-1516. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care. NLM UID: 8712059.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Boron Compounds -- Therapeutic Use
KW - Doxorubicin -- Therapeutic Use
KW - Neoplasm Recurrence, Local -- Drug Therapy
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Antibiotics, Antineoplastic -- Adverse Effects
KW - Antineoplastic Agents, Combined -- Adverse Effects
KW - Boron Compounds -- Adverse Effects
KW - Clinical Trials
KW - Disease Progression
KW - Doxorubicin -- Adverse Effects
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Female
KW - Heterocyclic Compounds -- Adverse Effects
KW - Kaplan-Meier Estimator
KW - Male
KW - Middle Age
KW - Random Assignment
KW - Salvage Therapy
KW - Treatment Outcomes
KW - United States
KW - Human
SP - 1503
EP - 1508
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 21
IS - 12
CY - Norwalk, Connecticut
PB - UBM Medica
AB - PURPOSE: On May 17, 2007, doxorubicin HCl liposome injection (Doxil) in combination with bortezomib (Velcade) received approval from the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple myeloma after at least one prior therapy that has not included bortezomib. Liposomal doxorubicin's efficacy and safety were demonstrated in a phase III, randomized, multicenter, international trial comparing the combination of this agent plus bortezomib vs bortezomib alone in multiple myeloma patients who had not previously received bortezomib and had received at least one prior therapy. Here we summarize the FDA review of the data that support this approval. EXPERIMENTAL DESIGN AND RESULTS: An interim analysis of time to disease progression (TTP), the primary endpoint, was conducted after 249 TTP events in this study that randomized 324 patients to liposomal doxorubicin plus bortezomib treatment and 322 patients to bortezomib monotherapy. Time to progression was significantly prolonged in the combination arm (median TTP = 9.3 months) compared with bortezomib monotherapy (median TTP = 6.5 months), P < .0001 (log-rank test); hazard ratio = 0.55 (95% confidence interval = 0.43-0.71). The response rates were similar between the two arms and not statistically different; however, among responding patients, the median duration of response was longer with the combination--10.2 months compared to 7.0 months in the monotherapy arm. Adverse reactions occurred more frequently with the combination therapy. As compared to the monotherapy, frequent grade 3/4 adverse reactions with the combination were neutropenia and thrombocytopenia. CONCLUSIONS: Liposomal doxorubicin received FDA approval for use in combination with bortezomib in patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy.
SN - 0890-9091
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 18077994.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mitnick, Carole D.
AU - Castro, Kenneth G.
AU - Harrington, Mark
AU - Sacks, Leonard V.
AU - Burman, William
T1 - Randomized Trials to Optimize Treatment of Multidrug-Resistant Tuberculosis.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2007/11//
VL - 4
IS - 11
M3 - Article
SP - e292
EP - 1734
PB - Public Library of Science
SN - 15491277
AB - The time is now right for randomized trials of MDR-TB, say the authors, as the expansion of MDR-TB programs provides the setting in which trials can be implemented. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Medicine is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANDOMIZED controlled trials
KW - TUBERCULOSIS
KW - MULTIDRUG resistance
KW - CLINICAL medicine -- Research
KW - PHARMACOLOGY
N1 - Accession Number: 27647444; Mitnick, Carole D. 1; Email Address: carole_mitnick@hms.harvard.edu Castro, Kenneth G. 2 Harrington, Mark 3 Sacks, Leonard V. 4 Burman, William 5; Affiliation: 1: Harvard Medical School, Boston, Massachusetts, United States of America 2: Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, United States 3: Treatment Action Group, New York, New York, United States of America 4: Food and Drug Administration, Rockville, Maryland, United States of America 5: Denver Public Health and the University of Colorado Health Sciences Center, Denver, Colorado, United States of America; Source Info: Nov2007, Vol. 4 Issue 11, pe292; Subject Term: RANDOMIZED controlled trials; Subject Term: TUBERCULOSIS; Subject Term: MULTIDRUG resistance; Subject Term: CLINICAL medicine -- Research; Subject Term: PHARMACOLOGY; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prinz, William A.
T1 - Non-vesicular sterol transport in cells
JO - Progress in Lipid Research
JF - Progress in Lipid Research
Y1 - 2007/11//
VL - 46
IS - 6
M3 - Article
SP - 297
EP - 314
SN - 01637827
AB - Abstract: Sterols such as cholesterol are important components of cellular membranes. They are not uniformly distributed among organelles and maintaining the proper distribution of sterols is critical for many cellular functions. Both vesicular and non-vesicular pathways move sterols between membranes and into and out of cells. There is growing evidence that a number of non-vesicular transport pathways operate in cells and, in the past few years, a number of proteins have been proposed to facilitate this transfer. Some are soluble sterol transfer proteins that may move sterol between membranes. Others are integral membranes proteins that mediate sterol efflux, uptake from cells, and perhaps intracellular sterol transfer as well. In most cases, the mechanisms and regulation of these proteins remains poorly understood. This review summarizes our current knowledge of these proteins and how they could contribute to intracellular sterol trafficking and distribution. [Copyright &y& Elsevier]
AB - Copyright of Progress in Lipid Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - STEROLS
KW - FATTY alcohols
KW - BIOLOGICAL membranes
KW - Cholestrol
KW - Lipid transport proteins
KW - Membranes
KW - Non-vesicular
KW - Transport
N1 - Accession Number: 26835611; Prinz, William A. 1; Email Address: wprinz@helix.nih.gov; Affiliation: 1: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Nov2007, Vol. 46 Issue 6, p297; Subject Term: CELLS; Subject Term: STEROLS; Subject Term: FATTY alcohols; Subject Term: BIOLOGICAL membranes; Author-Supplied Keyword: Cholestrol; Author-Supplied Keyword: Lipid transport proteins; Author-Supplied Keyword: Membranes; Author-Supplied Keyword: Non-vesicular; Author-Supplied Keyword: Transport; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 18p; Document Type: Article
L3 - 10.1016/j.plipres.2007.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Curtis, J. R.
AU - Kramer, J. M.
AU - Martin, C.
AU - Saag, K. G.
AU - Patkar, N.
AU - Shatin, D.
AU - Burgess, M.
AU - Xie, A.
AU - Braun, M. M.
T1 - Heart failure among younger rheumatoid arthritis and Crohn's patients exposed to TNF-α antagonists.
JO - Rheumatology
JF - Rheumatology
Y1 - 2007/11//
VL - 46
IS - 11
M3 - Article
SP - 1688
EP - 1693
SN - 14620324
AB - Objectives. New onset heart failure (HF) has been associated with the use of TNF-α antagonists etanercept and infliximab based upon spontaneous adverse event reports. HF clinical trials of these agents were stopped early due to futility or worsening of existing HF. A potential association between etanercept and infliximab and new onset HF has been studied minimally at a population level. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Rheumatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEART failure
KW - ETANERCEPT
KW - INFLIXIMAB
KW - CLINICAL trials
KW - RHEUMATOID arthritis
KW - adverse events
KW - Crohn's disease
KW - etanercept
KW - Heart failure
KW - infliximab
KW - rheumatoid arthritis
KW - TNF-α antagonists
KW - TNF-α antagonists
N1 - Accession Number: 44735818; Curtis, J. R. 1 Kramer, J. M. 2 Martin, C. 3 Saag, K. G. 1 Patkar, N. 1 Shatin, D. 3 Burgess, M. 3 Xie, A. 1 Braun, M. M. 4; Email Address: braunm@cber.fda.gov; Affiliation: 1: Center for Education and Research on Therapeutics of Musculoskeletal Disorders, The University of Alabama at Birmingham, Birmingham, AL 2: Center for Education and Research on Therapeutics of Cardiovascular Diseases, Duke University, Durham, NC 3: Center for Health Care Policy and Evaluation, Eden Prairie, MN 4: Food and Drug Administration, Rockville, MD, USA; Source Info: Nov2007, Vol. 46 Issue 11, p1688; Subject Term: HEART failure; Subject Term: ETANERCEPT; Subject Term: INFLIXIMAB; Subject Term: CLINICAL trials; Subject Term: RHEUMATOID arthritis; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: Crohn's disease; Author-Supplied Keyword: etanercept; Author-Supplied Keyword: Heart failure; Author-Supplied Keyword: infliximab; Author-Supplied Keyword: rheumatoid arthritis; Author-Supplied Keyword: TNF-α antagonists; Author-Supplied Keyword: TNF-α antagonists; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1093/rheumatology/kem212
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koumans, Emilia H.
AU - Sternberg, Maya
AU - Bruce, Carol
AU - McQuillan, Geraldine
AU - Kendrick, Juliette
AU - Sutton, Madeline
AU - Markowitz, Lauri E.
T1 - The Prevalence of Bacterial Vaginosis in the United States, 2001-2004; Associations With Symptoms, Sexual Behaviors, and Reproductive Health.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2007/11//
VL - 34
IS - 11
M3 - Article
SP - 864
EP - 869
SN - 01485717
AB - The article reports on the study concerning bacterial vaginosis (BV), a disturbance of vaginal microflora, which is a common cause of vaginal symptoms among reproductive-aged women in the U.S. It aims to determine the prevalence of BV, which is associated with an increased risk of acquisition of sexually transmitted infections, human immunodeficiency virus (HIV), and adverse pregnancy outcomes, among a representative sample of women of reproductive age in the country. Based on the results, the prevalence of BV was 29.9% corresponding to 21 million women with BV and only 15.7% of the women with BV reported vaginal symptoms. However, the research clarify the cause and risk factors for BV, methods to identify those at risk, and methods to reduce associated adverse health outcomes.
KW - MEDICAL research
KW - WOMEN -- Diseases
KW - BACTERIAL vaginitis
KW - BACTERIAL diseases
KW - SYMPTOMS
KW - DISEASE prevalence
KW - MEDICAL care
KW - PUBLIC health
KW - UNITED States
N1 - Accession Number: 27272917; Koumans, Emilia H. 1; Email Address: exk0@cdc.gov Sternberg, Maya 1 Bruce, Carol 1 McQuillan, Geraldine 2 Kendrick, Juliette 1 Sutton, Madeline 1 Markowitz, Lauri E. 1; Affiliation: 1: Centers for Disease Control and Prevention, Atlanta, GA 2: Department of Health and Human Services, US Public Health Service, Hyattsville, MD; Source Info: Nov2007, Vol. 34 Issue 11, p864; Subject Term: MEDICAL research; Subject Term: WOMEN -- Diseases; Subject Term: BACTERIAL vaginitis; Subject Term: BACTERIAL diseases; Subject Term: SYMPTOMS; Subject Term: DISEASE prevalence; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1097/OLQ.0b013e318074e565
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yan, J.
AU - Xia, Q.
AU - Wamer, W. G.
AU - Boudreau, M. D.
AU - Warbritton, A.
AU - Howard, P. C.
AU - Fu, P. P.
T1 - Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2007/11//
VL - 23
IS - 10
M3 - Article
SP - 581
EP - 589
PB - Sage Publications, Ltd.
SN - 07482337
AB - Retinyl esters account for more than 70% of the endogenous vitamin A found in human skin, and retinyl palmitate is one of the retinyl esters in this pool. Human skin is also exposed to retinyl palmitate exogenously through the topical application of cosmetic and skin care products that contain retinyl palmitate. To date, there is limited information on the penetration and distribution of retinyl palmitate and vitamin A within in the skin. In this study, the accumulation of retinyl palmitate and generation of retinol in the skin of male and female SKH- 1 mice that received repeated topical applications of creams containing 0.0%, 0.1%, 0.5%, 1.0%, 5.0%, 10%, or 13% of retinyl palmitate 5 days a week for a period of 13 weeks were studied. Because products containing retinyl palmitate are frequently applied to sun-exposed skin, and because it is well established that exposure to sunlight and UV light can alter cutaneous levels of retinoids, mice in this study were additionally exposed 5 days a week to simulated solar light. The results showed that retinyl palmitate diffused into the skin and was partially hydrolyzed to retinol. The levels of retinyl palmitate in the skin of mice that were administered retinyl palmitate cream were higher than control values, and levels of both retinyl palmitate and retinol increased with the application of higher concentrations of retinyl palmitate in the cream. Our results indicate that topically applied retinyl palmitate may alter the normal physiological levels of retinyl palmitate and retinol in the skin of SKH-1 mice and may have a significant impact on vitamin A homeostasis in the skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mice
KW - Biological control systems
KW - Organic compounds
KW - Ultraviolet radiation
KW - Homeostasis
KW - Vitamin A
KW - Fat-soluble vitamins
KW - Skin care
KW - Carotenes
KW - light exposure
KW - mouse skin
KW - retinol
KW - retinyl palmitate
N1 - Accession Number: 34060218; Yan, J. 1; Xia, Q. 1; Wamer, W. G. 2; Boudreau, M. D. 1; Warbritton, A. 3; Howard, P. C. 1; Fu, P. P. 1; Email Address: peterfu@fda.hhs.gov; Affiliations: 1: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA; 2: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA; 3: Toxicological Pathology Associates, Jefferson, Arkansas, USA; Issue Info: Nov2007, Vol. 23 Issue 10, p581; Thesaurus Term: Mice; Thesaurus Term: Biological control systems; Thesaurus Term: Organic compounds; Thesaurus Term: Ultraviolet radiation; Thesaurus Term: Homeostasis; Subject Term: Vitamin A; Subject Term: Fat-soluble vitamins; Subject Term: Skin care; Subject Term: Carotenes; Author-Supplied Keyword: light exposure; Author-Supplied Keyword: mouse skin; Author-Supplied Keyword: retinol; Author-Supplied Keyword: retinyl palmitate; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yin, J. J.
AU - Xia, Q.
AU - Fu, P. P.
T1 - UVA photoirradiation of anhydroretinol - formation of singlet oxygen and superoxide.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2007/11//
VL - 23
IS - 10
M3 - Article
SP - 625
EP - 631
PB - Sage Publications, Ltd.
SN - 07482337
AB - Anhydroretinol is a metabolite of vitamin A (retinol) and a major photodecomposition product of retinyl palmitate and retinyl acetate. Anhydroretinol is biologically active, inducing cell death in lymphoblastoid cells, prevention of N-methyl-N-nitrosourea-induced mammary cancer, and inhibition of cell growth in lymphocytes. We have previously determined that photoirradiation of anhydroretinol in the presence of a lipid, methyl linoleate, with UVA light-induced lipid peroxidation. In the present study, electron spin resonance (ESR) spin-trap techniques were employed to explore the mechanism of lipid peroxidation initiation. Irradiation of anhydroretinol by UVA in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. During photoirradiation in the presence of 5,5-dimethyl N-oxide pyrroline (DMPO), a specific probe for superoxide, ESR signals for DMPO-OOH were formed, and these signals were quenched by superoxide dismutase. The involvement of singlet oxygen on the induction of lipid peroxidation was also evidenced by the observation that lipid peroxidation was inhibited by sodium azide and enhanced by deuterium oxide. Our overall results provide evidence that photoirradiation of anhydroretinol with UVA light generates reactive oxygen species, e.g. singlet oxygen and superoxide, which mediate the induction of lipid peroxidation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mouse mammary tumor virus
KW - Vitamin A
KW - Active oxygen
KW - Superoxide dismutase
KW - Electron paramagnetic resonance
KW - Deuterium oxide
KW - Peroxidation
KW - Linoleic acid
KW - Lipids
KW - anhydroretinol
KW - ESR
KW - lipid peroxidation
KW - photoirradiation
KW - reactive oxygen species
KW - UVA light
N1 - Accession Number: 34060223; Yin, J. J. 1; Email Address: junjie.yin@fda.hhs.gov; Xia, Q. 2; Fu, P. P. 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA; 2: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA; Issue Info: Nov2007, Vol. 23 Issue 10, p625; Subject Term: Mouse mammary tumor virus; Subject Term: Vitamin A; Subject Term: Active oxygen; Subject Term: Superoxide dismutase; Subject Term: Electron paramagnetic resonance; Subject Term: Deuterium oxide; Subject Term: Peroxidation; Subject Term: Linoleic acid; Subject Term: Lipids; Author-Supplied Keyword: anhydroretinol; Author-Supplied Keyword: ESR; Author-Supplied Keyword: lipid peroxidation; Author-Supplied Keyword: photoirradiation; Author-Supplied Keyword: reactive oxygen species; Author-Supplied Keyword: UVA light; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Illustrations: 3 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34060223&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xie, Hang
AU - Liu, Teresa
AU - Chen, Hong
AU - Huang, Xiaoyuan
AU - Ye, Zhiping
T1 - Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid
JO - Vaccine
JF - Vaccine
Y1 - 2007/11//
VL - 25
IS - 44
M3 - Article
SP - 7649
EP - 7655
SN - 0264410X
AB - Abstract: A DNA plasmid expressing both the influenza viral matrix protein (M1) and hemagglutinin (HA) (pHA/M1) as a potential vaccine candidate was investigated. Vaccination with pHA/M1 double insertion plasmids not only induced HA-specific protective antibodies, but also elicited HA and M1-specific CD8 T cell responses. Mice immunized with pHA/M1 dual expressing plasmid showed enhanced HA inhibition titer and increased CD69+ CD8α+ T cell response compared to groups that received either the vector or a mixture of both pHA and pM1 (pHA+pM1). Furthermore, pHA/M1 immunization resulted in improved protection against both homologous and heterologous challenges. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Nucleic acids
KW - Preventive medicine
KW - Respiratory infections
KW - DNA vaccine
KW - Influenza
KW - T cell
N1 - Accession Number: 27052061; Xie, Hang; Email Address: Hang.Xie@fda.hhs.gov; Liu, Teresa 1; Chen, Hong 1; Huang, Xiaoyuan 1; Ye, Zhiping; Email Address: Zhiping.Ye@fda.hhs.gov; Affiliations: 1: Laboratory of Pediatric and Respiratory Virus Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 29A Lincoln Drive, Room 1B11, Bethesda, MD 20892, United States; Issue Info: Nov2007, Vol. 25 Issue 44, p7649; Thesaurus Term: Virus diseases; Thesaurus Term: Nucleic acids; Subject Term: Preventive medicine; Subject Term: Respiratory infections; Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: Influenza; Author-Supplied Keyword: T cell; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.08.052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27052061&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105836146
T1 - Frontiers in gender-based research: health care quality data.
AU - Moy E
AU - Dayton E
Y1 - 2007/11//
N1 - Accession Number: 105836146. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Women's Health. NLM UID: 9101000.
KW - Health and Welfare Planning
KW - Health Services Research
KW - Men's Health
KW - Primary Health Care -- Statistics and Numerical Data
KW - Quality of Health Care -- Statistics and Numerical Data
KW - Women's Health Services -- Statistics and Numerical Data
KW - Clinical Indicators
KW - Female
KW - Health Status
KW - Male
KW - Sex Factors
KW - United States
KW - Women's Health Services -- Standards
SP - 334
EP - 337
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 17
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, Rockville, Maryland
U2 - PMID: 17951071.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105836146&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2007-18193-002
AN - 2007-18193-002
AU - Ikemoto, Satoshi
T1 - Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.
JF - Brain Research Reviews
JO - Brain Research Reviews
JA - Brain Res Rev
Y1 - 2007/11//
VL - 56
IS - 1
SP - 27
EP - 78
CY - Netherlands
PB - Elsevier Science
SN - 0165-0173
AD - Ikemoto, Satoshi, NIDA, Behavioral Neuroscience Branch, 5500 Nathan Shock Drive, Baltimore, MD, US, 21224
N1 - Accession Number: 2007-18193-002. PMID: 17574681 Partial author list: First Author & Affiliation: Ikemoto, Satoshi; Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD, US. Release Date: 20080303. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Mesencephalon; Neuroanatomy; Nucleus Accumbens; Rewards. Minor Descriptor: Neurons; Rats; Tegmentum; Visual Cortex; Cerebrum. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Methodology: Literature Review. References Available: Y. Page Count: 52. Issue Publication Date: Nov, 2007.
AB - Anatomical and functional refinements of the meso-limbic dopamine system of the rat are discussed. Present experiments suggest that dopaminergic neurons localized in the posteromedial ventral tegmental area (VTA) and central linear nucleus raphe selectively project to the ventromedial striatum (medial olfactory tubercle and medial nucleus accumbens shell), whereas the anteromedial VTA has few if any projections to the ventral striatum, and the lateral VTA largely projects to the ventrolateral striatum (accumbens core, lateral shell and lateral tubercle). These findings complement the recent behavioral findings that cocaine and amphetamine are more rewarding when administered into the ventromedial striatum than into the ventrolateral striatum. Drugs such as nicotine and opiates are more rewarding when administered into the posterior VTA or the central linear nucleus than into the anterior VTA. A review of the literature suggests that (1) the midbrain has corresponding zones for the accumbens core and medial shell; (2) the striatal portion of the olfactory tubercle is a ventral extension of the nucleus accumbens shell; and (3) a model of two dopamine projection systems from the ventral midbrain to the ventral striatum is useful for understanding reward function. The medial projection system is important in the regulation of arousal characterized by affect and drive and plays a different role in goal-directed learning than the lateral projection system, as described in the variation-selection hypothesis of striatal functional organization. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dopamine
KW - reward circuitry
KW - ventral midbrain
KW - nucleus accumbens olfactory tubercle complex
KW - rats
KW - neurons
KW - midbrain
KW - 2007
KW - Dopamine
KW - Mesencephalon
KW - Neuroanatomy
KW - Nucleus Accumbens
KW - Rewards
KW - Neurons
KW - Rats
KW - Tegmentum
KW - Visual Cortex
KW - Cerebrum
KW - 2007
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program. Recipients: No recipient indicated
DO - 10.1016/j.brainresrev.2007.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18193-002&site=ehost-live&scope=site
UR - ORCID: 0000-0002-0732-7386
UR - sikemoto@intra.nida.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-13274-005
AN - 2009-13274-005
AU - Holden, E. Wayne
AU - O'Connell, Susan Rousseau
AU - Liao, Qinghong
AU - Krivelyova, Anna
AU - Connor, Tim
AU - Blau, Gary
AU - Long, Dorian
T1 - Outcomes of a randomized trial of continuum of care services for children in a child welfare system.
JF - Child Welfare: Journal of Policy, Practice, and Program
JO - Child Welfare: Journal of Policy, Practice, and Program
JA - Child Welfare
Y1 - 2007/11//Nov-Dec, 2007
VL - 86
IS - 6
SP - 89
EP - 114
CY - US
PB - Child Welfare League of America
SN - 0009-4021
AD - Holden, E. Wayne, RTI International, 3040 Cornwallis Road, P.O. Box 12194, Research Triangle Park, NC, US, 27709
N1 - Accession Number: 2009-13274-005. PMID: 18456984 Partial author list: First Author & Affiliation: Holden, E. Wayne; Social and Statistical Sciences, RTI International, Research Triangle Park, NC, US. Release Date: 20090921. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Case Management; Community Welfare Services; Continuum of Care; Mental Health Services; Residential Care Institutions. Minor Descriptor: Cost Containment; Health Care Costs; Treatment Duration; Quality of Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Child and Adolescent Functional Assessment Scale; Behavioral and Emotional Rating Scale; Restrictiveness of Living Environments Scale, revised version; Multi-Sector Service Contacts questionnaire; Child Behavior Checklist; Descriptive Information Questionnaire DOI: 10.1037/t45162-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 26. Issue Publication Date: Nov-Dec, 2007.
AB - The Connecticut Department of Children and Families Title IV-E waiver demonstration evaluated whether the well-being of children approved for residential mental health services could be improved, and lengths of stay in restrictive placements reduced, by providing case rate payments to community agencies to provide continuum of care services. Children between ages 7 and 15 were randomly assigned to either the demonstration group (n = 78) or to usual state-supported services (n = 79). One-year outcome results indicated that in a situation that is less costly, improvement in outcomes occurred in less restrictive settings. Continuum of care services were more effective in 1) returning children to in-home placements, 2) reducing the length of stay in restrictive placements, and (3) utilizing higher levels of case management through coordination among agencies and family support services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - residential mental health services
KW - continuum of care
KW - community agencies
KW - cost reduction
KW - quality of services
KW - length of stay reduction
KW - case management
KW - child welfare systems
KW - 2007
KW - Case Management
KW - Community Welfare Services
KW - Continuum of Care
KW - Mental Health Services
KW - Residential Care Institutions
KW - Cost Containment
KW - Health Care Costs
KW - Treatment Duration
KW - Quality of Services
KW - 2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13274-005&site=ehost-live&scope=site
UR - wholden@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09441-001
AN - 2008-09441-001
AU - Moy, Ernest
AU - Dayton, Elizabeth
T1 - Frontiers in gender-based research: Health care quality data.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2007/11//Nov-Dec, 2007
VL - 17
IS - 6
SP - 334
EP - 337
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Moy, Ernest, Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2008-09441-001. PMID: 17951071 Partial author list: First Author & Affiliation: Moy, Ernest; Agency for Healthcare Research and Quality, Center for Quality Improvement and Patient Safety, Rockville, MD, US. Release Date: 20090824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Health Care Services; Human Sex Differences; Health Disparities. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). References Available: Y. Page Count: 4. Issue Publication Date: Nov-Dec, 2007.
AB - Disparities research helps to improve understanding of where health care is exemplar, where it falls far short of its potential, and where interventions are likely to bear the greatest impact. The National Healthcare Disparities Report (NHDR) brings together a breadth of data sources, many of which have been underutilized to date but which could valuably be examined to better understand gender disparities in care, especially with regard to some components of care of particular importance for women. This editorial aims to equip readers with knowledge of often underused data sources included in the NHDR appendices, many of which are usable and appropriate for gender-based analyses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gender disparities
KW - health care disparities
KW - 2007
KW - Health Care Services
KW - Human Sex Differences
KW - Health Disparities
KW - 2007
DO - 10.1016/j.whi.2007.08.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09441-001&site=ehost-live&scope=site
UR - ernest.moy@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18362-007
AN - 2007-18362-007
AU - Schwab, Karen A.
AU - Ivins, Brian
AU - Cramer, Gayle
AU - Johnson, Wayne
AU - Sluss-Tiller, Melissa
AU - Kiley, Kevin
AU - Lux, Warren
AU - Warden, Deborah
T1 - Screening for traumatic brain injury in troops returning from deployment in Afghanistan and Iraq: Initial investigation of the usefulness of a short screening tool for traumatic brain injury.
JF - The Journal of Head Trauma Rehabilitation
JO - The Journal of Head Trauma Rehabilitation
JA - J Head Trauma Rehabil
Y1 - 2007/11//Nov-Dec, 2007
VL - 22
IS - 6
SP - 377
EP - 389
CY - US
PB - Lippincott Williams & Wilkins
SN - 0885-9701
SN - 1550-509X
AD - Schwab, Karen A., Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Washington, DC, US, 20012
N1 - Accession Number: 2007-18362-007. PMID: 18025970 Partial author list: First Author & Affiliation: Schwab, Karen A.; Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Washington, DC, US. Release Date: 20080728. Correction Date: 20091026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Army Personnel; Health Screening; Military Deployment; Neuropsychological Assessment; Traumatic Brain Injury. Minor Descriptor: Test Reliability; Test Validity. Classification: Neuropsychological Assessment (2225); Neurological Disorders & Brain Damage (3297). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: Brief Traumatic Brain Injury Screen; Computerized TBI Questionnaire; Neurobehavioral Symptom Inventory. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Nov-Dec, 2007.
AB - Objective: Preliminary assessment of a new instrument, the Brief Traumatic Brain Injury Screen (BTBIS). Design: Cross-sectional study of 596 soldiers returning from Iraq and/or Afghanistan, comparing the consistency of their reports of traumatic brain injury (TBI) across instruments with similar TBI questions, and in a brief follow-up interview. Setting: Military base. Measures: Self-reported probable TBI on the BTBIS and on 2 longer questionnaires, and a brief follow-up interview. Results: Self-reports of probable TBI were higher on the BTBIS, than on the longer instruments. Participants who screened positive on the BTBIS generally provided consistent information about probable TBI in the follow-up interview. Conclusions: In this initial study, the BTBIS demonstrated promise as part of a triage process in mass casualty situations, permitting individuals with probable TBI to self-report injury and continued symptoms. Further study, including full validation and reliability assessment, is warranted and required before these screening tools can be fully evaluated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - screening
KW - traumatic brain injury
KW - deployment
KW - Brief Traumatic Brain Injury Screen
KW - validity
KW - reliability
KW - US army
KW - 2007
KW - Army Personnel
KW - Health Screening
KW - Military Deployment
KW - Neuropsychological Assessment
KW - Traumatic Brain Injury
KW - Test Reliability
KW - Test Validity
KW - 2007
DO - 10.1097/01.HTR.0000300233.98242.87
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18362-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18248-005
AN - 2007-18248-005
AU - Goodman, Catherine
AU - Kachur, S. Patrick
AU - Abdulla, Salim
AU - Bloland, Peter
AU - Mills, Anne
T1 - Drug shop regulation and malaria treatment in Tanzania--Why do shops break the rules, and does it matter?
JF - Health Policy and Planning
JO - Health Policy and Planning
JA - Health Policy Plan
Y1 - 2007/11//
VL - 22
IS - 6
SP - 393
EP - 403
CY - United Kingdom
PB - Oxford University Press
SN - 0268-1080
SN - 1460-2237
AD - Goodman, Catherine, KEMRI, Wellcome Trust Collaborative Research Programme, PO Box 43640, Nairobi, Kenya
N1 - Accession Number: 2007-18248-005. PMID: 17921151 Partial author list: First Author & Affiliation: Goodman, Catherine; Health Policy Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom. Release Date: 20080303. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Goodman, Catherine. Major Descriptor: Drug Therapy; Health; Malaria; Pharmaceutical Industry; Retailing. Minor Descriptor: Countries; Lower Income Level. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: Tanzania. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov, 2007.
AB - Regulatory infringements are extremely common in low-income countries, especially with respect to retail pharmaceutical sales. There have been few practical suggestions on public policy responses other than stricter regulatory enforcement, which governments are often unable, or unwilling, to do. This paper explores the challenges of regulating retail drug sellers, and potential solutions, through a case study of malaria treatment in rural Tanzania where small drug shops are a common source of medicine. Infringement of health-related regulation was extremely common. Most stores lacked valid permits, and illegal stocking of prescription-only medicines and unpackaged tablets was the norm. Most stocked unregistered drugs, and no serving staff met the qualification requirements. Infringements are likely to have reflected infrequent regulatory inspections, a failure of regulatory authorities to implement sanctions, successful concealment of regulatory violations, and the tacit permission of local regulatory staff. Eliminating regulatory infringements is unlikely to be feasible, and could be undesirable if access to essential medicines is reduced. Alternatives include bringing official drug regulation closer into line with locally legitimate practices; greater use of positive incentives for providers; and consumer involvement. Such a change in approach has the potential to provide a firmer platform for public-private collaboration to improve shop-based treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug shop regulation
KW - malaria treatment
KW - retail pharmaceutical sales
KW - low-income countries
KW - 2007
KW - Drug Therapy
KW - Health
KW - Malaria
KW - Pharmaceutical Industry
KW - Retailing
KW - Countries
KW - Lower Income Level
KW - 2007
U1 - Sponsor: US Agency for International Development, US. Other Details: IMPACT-Tz. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: Wellcome Trust. Recipients: No recipient indicated
U1 - Sponsor: Wellcome Trust. Grant: 060184. Date: from 2001 to 2004. Other Details: Research Training Fellowship. Recipients: Goodman, Catherine
U1 - Sponsor: Economic and Social Research Council. Grant: PTA-026- 27-0179. Date: from 2004 to 2005. Other Details: Postdoctoral Fellowship. Recipients: No recipient indicated
U1 - Sponsor: UK Department for International Development, United Kingdom. Other Details: Consortium for Research on Equitable Health Systems. Recipients: Goodman, Catherine; Mills, Anne
U1 - Sponsor: LSHTM, Health Economics and Financing Programme. Recipients: No recipient indicated
DO - 10.1093/heapol/czm033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18248-005&site=ehost-live&scope=site
UR - ORCID: 0000-0001-9863-9950
UR -
UR - catherine.goodman@lshtm.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18328-007
AN - 2007-18328-007
AU - Masland, Mary C.
AU - Snowden, Lonnie R.
AU - Wallace, Neal T.
T1 - Assessment, authorization and access to Medicaid managed mental health care.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2007/11//
VL - 34
IS - 6
SP - 548
EP - 562
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Masland, Mary C., Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, 2140 Shattuck Ave, #409, Berkeley, CA, US, 94720-1414
N1 - Accession Number: 2007-18328-007. PMID: 17929160 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Masland, Mary C.; Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley, CA, US. Release Date: 20071217. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Utilization; Managed Care; Medicaid; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Nov, 2007.
AB - Examined were effects on access of managed care assessment and authorization processes in California's 57 county mental health plans. Primary data on managed care implementation were collected from surveys of county plan administrators; secondary data were from Medicaid claims and enrollment files. Using multivariate fixed effects regression, we found that following implementation of managed care, greater access occurred in county plans where assessments and treatment were performed by the same clinician, and where service authorizations were made more rapidly. Lower access occurred in county plans where treating clinicians authorized services themselves. Results confirm the significant effects of managed care processes on outcomes and highlight the importance of system capacity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - Medicaid
KW - health care access
KW - managed care assessment
KW - authorization
KW - 2007
KW - Health Care Utilization
KW - Managed Care
KW - Medicaid
KW - Mental Health Services
KW - 2007
DO - 10.1007/s10488-007-0138-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18328-007&site=ehost-live&scope=site
UR - mmasland@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18069-005
AN - 2007-18069-005
AU - Ferguson, Sherry A.
AU - Cisneros, F. Javier
AU - Hanig, Joseph P.
AU - Berry, Kimberly J.
T1 - Oral treatment with ACCUTANE® does not increase measures of anhedonia or depression in rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2007/11//Nov-Dec, 2007
VL - 29
IS - 6
SP - 642
EP - 651
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Ferguson, Sherry A., Division of Neurotoxicology, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2007-18069-005. PMID: 17933491 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20080324. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Cisneros, F. Javier. Major Descriptor: Acids; Anhedonia; Animal Ethology; Animal Models. Minor Descriptor: Rats; Rodents. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov-Dec, 2007.
AB - Reports of depression and/or suicide with ACCUTANE® (13-cis-retinoic acid (13-cis-RA)) use prompted studies in a rodent model to ascertain its potential effects. Previously, there were no effects on measures of anhedonia (intake of a saccharin-flavored solution) and depression (forced swim test (FST) behaviors) in rats treated with 7.5 or 22.5 mg/kg 13-cis-RA [S.A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459.]. Here, dose and temporal thresholds were investigated by increasing the maximum 13-cis-RA dose to 30 mg/kg, extending treatment duration, and measuring behaviors repeatedly. Beginning on post-natal day 59, male and female Sprague-Dawley rats were gavaged with soybean oil, 7.5 or 30 mg/kg/day of 13-cis-RA for approximately 19 weeks. FST behaviors were measured after 24, 82, and 131 treatment days and saccharin intake (0.03% solution) was measured at baseline and after 14, 35, 56, and 112 treatment days. Body weight and food intake were not altered by treatment. FST durations of swim, climb/struggle, and immobility were unaffected by 13-cis-RA at any time during treatment. More males than females required 'rescue' in the FST but there was no treatment effect on number of rats requiring early removal. 13-cis-RA treatment had no effects on saccharin intake at any time. Given that the 7.5 mg/kg dose produces serum levels which parallel those of humans [S.A. Ferguson, P.H. Siitonen, F.J. Cisneros, B. Gough, J.F. Young, Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats, Basic Clin. Pharmacol. Toxicol 98 (2006) 582-587.], these results are quite relevant. Combined with previous results, these results provide further evidence that 13-cis-RA does not produce behavioral alterations indicative of depression in rats. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oral treatment
KW - anhedonia
KW - depression
KW - rats
KW - retinoic acid
KW - rodent model
KW - 2007
KW - Acids
KW - Anhedonia
KW - Animal Ethology
KW - Animal Models
KW - Rats
KW - Rodents
KW - 2007
U1 - Sponsor: Oak Ridge Institute for Science and Education, US. Other Details: Through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. Recipients: Cisneros, F. Javier; Berry, Kimberly J.
DO - 10.1016/j.ntt.2007.09.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18069-005&site=ehost-live&scope=site
UR - Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17155-001
AN - 2007-17155-001
AU - Purcell, David W.
AU - Latka, Mary H.
AU - Metsch, Lisa R.
AU - Latkin, Carl A.
AU - Gómez, Cynthia A.
AU - Mizuno, Yuko
AU - Arnsten, Julia H.
AU - Wilkinson, James D.
AU - Knight, Kelly R.
AU - Knowlton, Amy R.
AU - Santibanez, Scott
AU - Tobin, Karin E.
AU - Rose, Carol Dawson
AU - Valverde, Eduardo E.
AU - Gourevitch, Marc N.
AU - Eldred, Lois
AU - Borkowf, Craig B.
T1 - Results from a randomized controlled trial of a peer-mentoring intervention to reduce HIV transmission and increase access to care and adherence to HIV medications among HIV-seropositive injection drug users.
T3 - HIV prevention and clinical care for HIV-positive injection drug users: Lessons from the INSPIRE Study
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2007/11//
VL - 46
IS - Suppl 2
SP - S35
EP - S47
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Purcell, David W., Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, 1600 Cliftonn Road, MS E-37, Atlanta, GA, US, 30333
N1 - Accession Number: 2007-17155-001. Partial author list: First Author & Affiliation: Purcell, David W.; Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, US. Institutional Authors: INSPIRE Study Team. Release Date: 20080707. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Disease Transmission; HIV; Intravenous Drug Usage; Treatment Compliance; Treatment Effectiveness Evaluation. Minor Descriptor: Drug Therapy; Health Care Services; Health Care Utilization; Intervention; Mentor; Peer Relations; Sexual Risk Taking; Treatment Outcomes. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Audio Computer-Assisted Self-Interview; Medical Outcome Study; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Followup Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 13. Issue Publication Date: Nov, 2007.
AB - Background: There is a lack of effective behavioral interventions for HIV-positive injection drug users (IDUs). We sought to evaluate the efficacy of an intervention to reduce sexual and injection transmission risk behaviors and to increase utilization of medical care and adherence to HIV medications among this population. Methods: HIV-positive IDUs (n = 966) recruited in 4 US cities were randomly assigned to a 10-session peer mentoring intervention or to an 8-session video discussion intervention (control condition). Participants completed audio computer-assisted self-interviews and had their blood drawn to measure CD4 cell count and viral load at baseline and at 3-month (no blood), 6-month, and 12-month follow-ups. Results: Overall retention rates for randomized participants were 87%, 83%, and 85% at 3, 6, and 12 months, respectively. Participants in both conditions reported significant reductions from baseline in injection and sexual transmission risk behaviors, but there were no significant differences between conditions. Participants in both conditions reported no change in medical care and adherence, and there were no significant differences between conditions. Conclusions: Both interventions led to decreases in risk behaviors but no changes in medical outcomes. The characteristics of the trial that may have contributed to these results are examined, and directions for future research are identified. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - peer-mentoring intervention
KW - HIV transmission
KW - health care
KW - treatment adherence
KW - HIV medications
KW - HIV-seropositive injection drug users
KW - sexual risk
KW - medical care utilization
KW - 2007
KW - Disease Transmission
KW - HIV
KW - Intravenous Drug Usage
KW - Treatment Compliance
KW - Treatment Effectiveness Evaluation
KW - Drug Therapy
KW - Health Care Services
KW - Health Care Utilization
KW - Intervention
KW - Mentor
KW - Peer Relations
KW - Sexual Risk Taking
KW - Treatment Outcomes
KW - 2007
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1097/QAI.0b013e31815767c4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17155-001&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6865-2126
UR -
UR - ORCID: 0000-0001-8125-5168
UR - dpurcell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17155-004
AN - 2007-17155-004
AU - Arnsten, Julia H.
AU - Li, Xuan
AU - Mizuno, Yuko
AU - Knowlton, Amy R.
AU - Gourevitch, Marc N.
AU - Handley, Kathleen
AU - Knight, Kelly R.
AU - Metsch, Lisa R.
T1 - Factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users.
T3 - HIV prevention and clinical care for HIV-positive injection drug users: Lessons from the INSPIRE Study
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2007/11//
VL - 46
IS - Suppl 2
SP - S64
EP - S71
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Arnsten, Julia H., Division of General Internal Medicine, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, NY, US, 10467
N1 - Accession Number: 2007-17155-004. Partial author list: First Author & Affiliation: Arnsten, Julia H.; Division of General Internal Medicine, Albert Einstein College of Medicine, Bronx, NY, US. Institutional Authors: INSPIRE Study Team. Release Date: 20080707. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antiviral Drugs; Drug Therapy; HIV; Intravenous Drug Usage; Treatment Compliance. Minor Descriptor: Errors; Self-Report. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Medical Outcomes Study; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2007.
AB - Background: Active drug use is often associated with poor adherence, but few studies have determined psychosocial correlates of adherence in injection drug users (IDUs). Methods: Of 1161 Intervention for Seropositive Injectors--Research and Evaluation study enrollees, 636 were taking antiretrovirals. We assessed self-reported adherence to self-reported antiretroviral regimens and medication errors, which we defined as daily doses that were inconsistent with standard or alternative antiretroviral prescriptions. Results: Most subjects (75%, n = 477) self-reported good (≥90%) adherence, which was strongly associated with an undetectable viral load. Good adherence was independently associated with being a high school graduate, not sharing injection equipment, fewer depressive symptoms, positive attitudes toward antiretrovirals, higher self-efficacy for taking antiretrovirals as prescribed, and greater sense of responsibility to protect others from HIV. Medication errors were made by 54% (n = 346) and were strongly associated with a detectable viral load and fewer CD4 cells. Errors were independently associated with nonwhite race and with depressive symptoms, poorer self-efficacy for safer drug use, and worse attitudes toward HIV medications. Conclusions: Modifiable factors associated with poor adherence, including depressive symptoms and poor self-efficacy, should be targeted for intervention. Because medication errors are prevalent and associated with a detectable viral load and fewer CD4 cells, interventions should include particular efforts to identify medication taking inconsistent with antiretroviral prescriptions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antiretroviral therapy
KW - therapy adherence
KW - medication errors
KW - HIV
KW - injection drug users
KW - self-report
KW - 2007
KW - Antiviral Drugs
KW - Drug Therapy
KW - HIV
KW - Intravenous Drug Usage
KW - Treatment Compliance
KW - Errors
KW - Self-Report
KW - 2007
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1097/QAI.0b013e31815767d6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17155-004&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6865-2126
UR -
UR - jarnsten@montefiore.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16598-009
AN - 2007-16598-009
AU - Hudson, Julie L.
AU - Miller, G. Edward
AU - Kirby, James B.
T1 - Explaining racial and ethnic differences in children's use of stimulant medications.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2007/11//
VL - 45
IS - 11
SP - 1068
EP - 1075
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Hudson, Julie L., Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2007-16598-009. PMID: 18049347 Partial author list: First Author & Affiliation: Hudson, Julie L.; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: CNS Stimulating Drugs; Racial and Ethnic Differences. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2007.
AB - Objectives: To document and explain racial/ethnic differences in the use of stimulant drugs among US children. Data and Methods: We use a nationally representative sample of children ages 5-17 years old from the Medical Expenditure Panel Survey (MEPS) for the years 2000-2002. We estimate race-specific means and regressions to highlight differences across groups in individual/family characteristics that may affect stimulant use and differences in responses to these characteristics. Then, we use Oaxaca-Blinder decomposition methods to quantify the portion of differential use explained by differences in individual/family characteristics. Finally, we use pooled regressions with race/ethnicity interactions to formally test the hypothesis that responses to perceived mental health and behavioral problems vary across groups. Results: White children are about twice as likely to use stimulants as either Hispanic or Black children. Differences in individual/family characteristics account for about 25% of the difference between whites and Hispanics, but for none of the difference between whites and blacks. Pooled regressions show that racial/ethnic gaps in stimulant use persist among children with otherwise similar reported mental health conditions. Conclusions: Our finding that the majority of racial/ethnic differences in children's stimulant use is explained by differences in responses to individual/family characteristics highlights the importance of further research to examine the reasons for these differences. It is striking that children with otherwise similar reports of mental health problems have such different outcomes in terms of stimulant use. Potential explanations range from discrimination to cultural differences by race/ethnicity or community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial differences
KW - ethnic differences
KW - stimulant medications
KW - 2007
KW - CNS Stimulating Drugs
KW - Racial and Ethnic Differences
KW - 2007
DO - 10.1097/MLR.0b013e31806728fa
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16598-009&site=ehost-live&scope=site
UR - jhudson@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18003-001
AN - 2007-18003-001
AU - Deuster, Patricia A.
AU - O'Connor, Francis G.
AU - Henry, Kurt A.
AU - Martindale, Valerie E.
AU - Talbot, Laura
AU - Jonas, Wayne
AU - Friedl, Karl
T1 - Human performance optimization: An evolving charge to the department of defense.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2007/11//
VL - 172
IS - 11
SP - 1133
EP - 1137
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Deuster, Patricia A., Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, US, 20814
N1 - Accession Number: 2007-18003-001. PMID: 18062384 Partial author list: First Author & Affiliation: Deuster, Patricia A.; Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, US. Release Date: 20080211. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Military Personnel; War. Classification: Military Psychology (3800). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 5. Issue Publication Date: Nov, 2007.
AB - Uniformed Services University of the Health Sciences hosted a conference in June 2006 entitled 'Human Performance Optimization in the Department of Defense: Charting a Course for the Future' with the goal of developing a strategic plan for human performance optimization (HPO) within the Department of Defense (DoD). The conference identified key issues: (1) advocating for HPO at all DoD levels, (2) defining HPO specific to DoD requirements, (3) developing valid and standardized metrics for HPO, (4) translating HPO research into the operational community, and (5) establishing effective communication and coordination across military services and within the medical, research and operational communities. The program objectives should enhance mental and physical resilience of the war fighter; accelerate recovery; reduce injury and illness; provide seamless knowledge transfer from laboratory to line; improve the human system contribution to mission success; and allow the U.S. to remain in the lead in this area. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - human performance optimization
KW - defense
KW - military services
KW - wars
KW - 2007
KW - Military Personnel
KW - War
KW - 2007
DO - 10.7205/MILMED.172.11.1133
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18003-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-10345-008
AN - 2008-10345-008
AU - Fisher, William H.
AU - Wolff, Nancy
AU - Grudzinskas, Albert J. Jr.
AU - Roy-Bujnowski, Kristen
AU - Banks, Steven M.
AU - Clayfield, Jonathan
T1 - Drug-related arrests in a cohort of public mental health service recipients.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/11//
VL - 58
IS - 11
SP - 1448
EP - 1453
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Fisher, William H., 55 Lake Ave. N., Worcester, MA, US, 01655
N1 - Accession Number: 2008-10345-008. PMID: 17978255 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Fisher, William H.; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080908. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Criminal Behavior; Epidemiology; Mental Disorders; Mental Health Services. Minor Descriptor: Drug Abuse. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2007.
AB - Objectives: The excessive prevalence of comorbid substance abuse among persons with severe mental illness has been well established and identified as the source of numerous negative outcomes. An overlooked aspect of illicit drug use in this population is its illegality and the potentially dire criminal sanctions. This study examined the prevalence of drug arrests in a cohort of persons receiving services from a state mental health agency who were followed for roughly ten years. Methods: Data on arrest spanning from 1991 to 2000 were obtained for all individuals receiving inpatient, case management, or residential services from July 1991 to June 1992 (N = 13,816). Reports of prevalence were based on the number with at least one drug-related arrest in the observation period. Results: Five percent of individuals in the cohort experienced at least one drug-related arrest (N = 720). These included simple possession as well as manufacturing and distribution. The prevalence was much higher (15%) among persons aged 18 to 25 years than in other age groups. Roughly 95% of persons with a drug arrest also had an arrest for another type of offense. This pattern is similar to that observed among persons with a drug-related arrest in the general population. Conclusions: Convictions on drug charges can void access to Section Eight housing and other benefits and are associated with other patterns of offending that also carry significant criminal sanctions. State mental health agencies may wish to target interventions toward youthful clientele by focusing specifically on the risks associated with involvement with illicit drugs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug-related arrests
KW - public mental health service recipients
KW - severe mental illness
KW - prevalence
KW - comorbidity
KW - criminal sanctions
KW - 2007
KW - Comorbidity
KW - Criminal Behavior
KW - Epidemiology
KW - Mental Disorders
KW - Mental Health Services
KW - Drug Abuse
KW - 2007
U1 - Sponsor: National Institute of Mental Health, US. Grant: RO1-MH- 65615. Recipients: No recipient indicated
DO - 10.1176/appi.ps.58.11.1448
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10345-008&site=ehost-live&scope=site
UR - bill.fisher@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-10345-009
AN - 2008-10345-009
AU - Davis, Maryann
AU - Banks, Steven M.
AU - Fisher, William H.
AU - Gershenson, Bernice
AU - Grudzinskas, Albert J. Jr.
T1 - Arrests of adolescent clients of a public mental health system during adolescence and young adulthood.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/11//
VL - 58
IS - 11
SP - 1454
EP - 1460
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Davis, Maryann, 55 Lake Ave. N., Worcester, MA, US, 01655
N1 - Accession Number: 2008-10345-009. PMID: 17978256 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20080908. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Davis, Maryann. Major Descriptor: Clients; Criminal Behavior; Legal Arrest; Mental Health Services. Minor Descriptor: Adolescent Attitudes; Justice. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Child and Adolescent Functional Assessment Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 2007.
AB - Objective: This study examined the relationship of age and gender with risk of arrest among adolescents and young adults who were intensive adolescent users of public mental health services. Methods: Data were obtained from the Massachusetts Department of Mental Health (DMH) and juvenile and criminal courts. Participants were youths receiving DMH adolescent case management services sometime in 1994-1996 who were born between 1976 and 1979 (781 males and 738 females). They were cross-matched to document arrests between age seven and 25. The study examined age at first arrest, age-specific risk, and the relationship between arrest history and arrest risk by gender and age. Results: Most males (69%) and almost half the females (46%) were arrested by age 25. First arrest was most common before age 18. As in the general population, males' arrest patterns were more concerning than those of females, although patterns were of concern in both groups. Most female arrestees had multiple arrests, many as adults. No gender differences were observed for several factors, including risk of first arrest over age 18. Risk was far greater for those arrested in the previous year than for those never arrested. Conclusions: Findings justify concerns of public mental health systems regarding justice system involvement of adolescent clients. Risk of first arrest was significant from early adolescence through age 24, indicating a need for arrest prevention into young adulthood. The heightened arrest risk at all ages among those who were recently arrested demarcates a population in need of immediate intervention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent clients arrests
KW - public mental health system
KW - mental health services
KW - arrest risk
KW - justice system
KW - 2007
KW - Clients
KW - Criminal Behavior
KW - Legal Arrest
KW - Mental Health Services
KW - Adolescent Attitudes
KW - Justice
KW - 2007
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01- MH-067862-01A1. Recipients: Davis, Maryann
DO - 10.1176/appi.ps.58.11.1454
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10345-009&site=ehost-live&scope=site
UR - maryann.davis@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17561-004
AN - 2007-17561-004
AU - Waters, T. R.
AU - Lu, M.-L.
AU - Occhipinti, E.
T1 - New procedure for assessing sequential manual lifting jobs using the revised NIOSH lifting equation.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2007/11//
VL - 50
IS - 11
SP - 1761
EP - 1770
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Waters, T. R.
N1 - Accession Number: 2007-17561-004. PMID: 17972201 Partial author list: First Author & Affiliation: Waters, T. R.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20080107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Measurement; Occupational Safety; Occupations; Workday Shifts. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2007.
AB - A sequential manual lifting job is defined as a job where workers rotate between a series of manual lifting rotation slots or elements at specified time intervals during the course of a work shift. The original NIOSH lifting equation lacked a method for assessing the physical demands of these types of jobs. This paper presents the sequential lifting index (SLI), a new conceptual method for assessing the physical demands for sequential manual lifting jobs. The new method is similar to the composite lifting index (CLI) method that was provided by NIOSH for assessing multi-task jobs. The SLI method expands upon the methods originally provided by NIOSH by providing a simple method for estimating the relative magnitude of physical stress for sequential manual lifting jobs. It should also be useful in assisting safety and health specialists to prioritize or rank hazardous jobs within a plant. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work shifts
KW - sequential manual lifting jobs
KW - assessment
KW - occupational safety
KW - 2007
KW - Measurement
KW - Occupational Safety
KW - Occupations
KW - Workday Shifts
KW - 2007
DO - 10.1080/00140130701674364
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17561-004&site=ehost-live&scope=site
UR - twaters@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-16840-008
AN - 2007-16840-008
AU - Snowden, Lonnie R.
AU - Masland, Mary C.
AU - Wallace, Neal T.
AU - Evans-Cuellar, Allison
T1 - Effects on outpatient and emergency mental health care of strict Medicaid early periodic screening, diagnosis, and treatment enforcement.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/11//
VL - 97
IS - 11
SP - 1951
EP - 1956
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Snowden, Lonnie R., School of Social Welfare, University of California, Berkeley, 200 Haviland MC 7400, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2007-16840-008. PMID: 17329640 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; School of Social Welfare, Institute of Personality and Social Research, University of California, Berkeley, CA, US. Release Date: 20080324. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Medicaid; Mental Health Services; Outpatient Treatment. Minor Descriptor: Diagnosis; Health Care Utilization; Screening. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2007.
AB - We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (outpatient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health care
KW - emergency services
KW - outpatient treatment
KW - periodic screening
KW - diagnosis
KW - treatment enforcement
KW - medicaid
KW - 2007
KW - Medicaid
KW - Mental Health Services
KW - Outpatient Treatment
KW - Diagnosis
KW - Health Care Utilization
KW - Screening
KW - 2007
U1 - Sponsor: California Health Care Foundation, US. Recipients: No recipient indicated
DO - 10.2105/AJPH.2006.094771
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16840-008&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-13395-001
AN - 2008-13395-001
AU - Espey, David K.
AU - Wu, Xiao-Cheng
AU - Swan, Judith
AU - Wiggins, Charles
AU - Jim, Melissa A.
AU - Ward, Elizabeth
AU - Wingo, Phyllis A.
AU - Howe, Holly L.
AU - Ries, Lynn A. G.
AU - Miller, Barry A.
AU - Jemal, Ahmedin
AU - Ahmed, Faruque
AU - Cobb, Nathaniel
AU - Kaur, Judith S.
AU - Edwards, Brenda K.
T1 - Annual report to the nation on the status of cancer, 1975-2004, featuring cancer in American Indians and Alaska Natives.
JF - Cancer
JO - Cancer
JA - Cancer
Y1 - 2007/11//
VL - 110
IS - 10
SP - 2119
EP - 2152
CY - US
PB - John Wiley & Sons
SN - 0008-543X
SN - 1097-0142
AD - Espey, David K., Division of Cancer Prevention and Control, Centers for Disease Prevention and Control, Indian Health Service, 5300 Homestead NE, Albuquerque, NM, US, 87110
N1 - Accession Number: 2008-13395-001. PMID: 17939129 Partial author list: First Author & Affiliation: Espey, David K.; Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20090921. Correction Date: 20130128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Cancer Screening; Neoplasms. Minor Descriptor: Information; Prevention. Classification: Cancer (3293). Population: Human (10). Location: US. References Available: Y. Page Count: 34. Issue Publication Date: Nov, 2007.
AB - Background: The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate annually to provide updated information on cancer occurrence and trends in the U.S. The 2007 report features a comprehensive compilation of cancer information for American Indians and Alaska Natives (AI/AN). Methods: Cancer incidence data were available for up to 82% of the U.S. population. Cancer deaths were available for the entire U.S. population. Long-term (1975 through 2004) and fixed-interval (1995 through 2004) incidence and mortality trends were evaluated by annual percent change using regression analyses (2-sided P <.05). Cancer screening, risk factors, socioeconomic characteristics, incidence data, and stage were compiled for non-Hispanic whites (NHW) and AI/AN across 6 regions of the U.S. Results: Overall cancer death rates decreased by 2.1% per year from 2002 through 2004, nearly twice the annual decrease of 1.1% per year from 1993 through 2002. Among men and women, death rates declined for most cancers. Among women, lung cancer incidence rates no longer were increasing and death rates, although they still were increasing slightly, were increasing at a much slower rate than in the past. Breast cancer incidence rates in women decreased 3.5% per year from 2001 to 2004, the first decrease observed in 20 years. Colorectal cancer incidence and death rates and prostate cancer death rates declined, with colorectal cancer death rates dropping more sharply from 2002 through 2004. Overall, rates for AI/AN were lower than for NHW from 1999 through 2004 for most cancers, but they were higher for cancers of the stomach, liver, cervix, kidney, and gallbladder. Regional analyses, however, revealed high rates for AI/ AN in the Northern and Southern Plains and Alaska. For cancers of the breast, colon and rectum, prostate, and cervix, AI/AN were less likely than NHW to be diagnosed at localized stages. Conclusions: For all races/ethnicities combined in the U.S., favorable trends in incidence and mortality were noted for lung and colorectal cancer in men and women and for breast cancer in women. For the AI/AN population, lower overall cancer incidence and death rates obscured important variations by geographic regions and less favorable healthcare access and socioeconomic status. Enhanced tobacco control and cancer screening, especially in the Northern and Southern Plains and Alaska, emerged as clear priorities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - annual report
KW - cancer status
KW - cancer occurrence
KW - cancer information
KW - American Cancer Society
KW - Centers for Disease Control and Prevention
KW - National Cancer Institute
KW - North American Association of Central Cancer Registries
KW - American Indians
KW - Alaska natives
KW - 2007
KW - Alaska Natives
KW - American Indians
KW - Cancer Screening
KW - Neoplasms
KW - Information
KW - Prevention
KW - 2007
DO - 10.1002/cncr.23044
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13395-001&site=ehost-live&scope=site
UR - david.espey@ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17155-010
AN - 2007-17155-010
AU - Knowlton, Amy R.
AU - Arnsten, Julia H.
AU - Gourevitch, Marc N.
AU - Eldred, Lois
AU - Wilkinson, James D.
AU - Rose, Carol Dawson
AU - Buchanan, Amy
AU - Purcell, David W.
T1 - Microsocial environmental influences on highly active antiretroviral therapy outcomes among active injection drug users: The role of informal caregiving and household factors.
T3 - HIV prevention and clinical care for HIV-positive injection drug users: Lessons from the INSPIRE Study
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2007/11//
VL - 46
IS - Suppl 2
SP - S110
EP - S119
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Knowlton, Amy R., Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 286, Baltimore, MD, US, 21205
N1 - Accession Number: 2007-17155-010. Partial author list: First Author & Affiliation: Knowlton, Amy R.; Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US. Institutional Authors: INSPIRE Study Team. Release Date: 20080707. Correction Date: 20160811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Antiviral Drugs; Drug Therapy; Environmental Effects; Intravenous Drug Usage; Treatment Outcomes. Minor Descriptor: Caregivers; Living Arrangements. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Audio Computer Assisted Self-Interview; Engagement With Health Care Provider Scale DOI: 10.1037/t50211-000; Brief Symptom Inventory DOI: 10.1037/t00789-000. Methodology: Empirical Study; Followup Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2007.
AB - Active injection drug users (IDUs) are at high risk of unsuccessful highly active antiretroviral therapy (HAART). We sought to identify baseline factors differentiating IDUs' treatment success versus treatment failure over time among those taking HAART. Interventions for Seropositive Injectors--Research and Evaluation (INSPIRE) study participants were assessed at baseline and at 6- and 12-month follow-ups. Multinominal regression determined baseline predictors of achieving or maintaining viral suppression relative to maintaining detectable viral loads over 12 months. Of 199 participants who were retained and remained on HAART, 133 (67%) had viral load change patterns included in the analysis. At follow-up, 66% maintained detectable viral loads and 15% achieved and 19% maintained viral suppression. Results indicated that those having informal care (instrumental or emotional support) were 4.6 times more likely to achieve or maintain viral suppression relative to experiencing treatment failure. Those who maintained viral suppression were 3.5 times less likely to live alone or to report social discomfort in taking HAART. Study results underscore the importance of micro-social factors of social network support, social isolation, and social stigma for successful HAART outcomes among IDUs. The findings suggest that adherence interventions for IDUs should promote existing informal HIV caregiving, living with supportive others, and positive medication-taking norms among social networks. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - microsocial environmental influences
KW - highly active antiretroviral therapy
KW - therapy outcomes
KW - injection drug users
KW - informal caregiving
KW - household factors
KW - 2007
KW - Antiviral Drugs
KW - Drug Therapy
KW - Environmental Effects
KW - Intravenous Drug Usage
KW - Treatment Outcomes
KW - Caregivers
KW - Living Arrangements
KW - 2007
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1097/QAI.0b013e31815767f8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17155-010&site=ehost-live&scope=site
UR - ORCID: 0000-0001-8125-5168
UR - ORCID: 0000-0001-6865-2126
UR -
UR - aknowlto@jhsph.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19840-003
AN - 2007-19840-003
AU - Iizuka, Yukihiko
AU - Sei, Yoshitatsu
AU - Weinberger, Daniel R.
AU - Straub, Richard E.
T1 - Evidence that the BLOC-1 protein dysbindin modulates dopamine D₂ receptor internalization and signaling but not D₁ internalization.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2007/11//
VL - 27
IS - 45
SP - 12390
EP - 12395
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Straub, Richard E., Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, 10 Center Drive Building 10, Room 4D18, Bethesda, MD, US, 20892-1385
N1 - Accession Number: 2007-19840-003. PMID: 17989303 Partial author list: First Author & Affiliation: Iizuka, Yukihiko; Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, US. Release Date: 20080310. Correction Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Models; Dopamine; Neurotransmission; Rats; Schizophrenia. Minor Descriptor: Neural Receptors; Proteins; Ribonucleic Acid. Classification: Neuropsychology & Neurology (2520); Schizophrenia & Psychotic States (3213). Population: Human (10); Animal (20). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Tables and Figures Internet. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2007.
AB - The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin expression is reduced in schizophrenic brain tissue, but the molecular mechanisms by which this contributes to pathogenesis and symptomatology are unknown. We studied the effects of transfection of DTNBP1 siRNA on cell surface levels of dopamine D₂ receptor (DRD2) in human SH-SY5Y neuroblastoma cells and in rat primary cortical neurons. DTNBP1 siRNA decreased dysbindin protein, increased cell surface DRD2 and blocked dopamine-induced DRD2 internalization. MUTED siRNA produced similar effects. In contrast, decreased dysbindin did not change dopamine D₁ receptor (DRD1) levels, or its basal or dopamine-induced internalization. The DRD2 agonist quinpirole reduced phosphorylation of CREB (cAMP response element-binding protein) in dysbindin downregulated cells, demonstrating enhanced intracellular signaling caused by the upregulation of DRD2. This is the first demonstration of a schizophrenia susceptibility gene exerting a functional effect on DRD2 signaling, a pathway that has long been implicated in the illness. We propose a molecular mechanism for pathogenesis in which risk alleles in DTNBP1, or other factors that also downregulate dysbindin, compromise the ability of BLOC-1 to traffic DRD2 toward degradation, but has little effect on DRD1 trafficking. Impaired trafficking of DRD2 decreases dopamine-induced internalization, and with more receptors retained on the cell surface, dopamine stimulation produces excess intracellular signaling. Such an increase in DRD2 signaling relative to DRD1 would contribute to the imbalances in dopaminergic neurotransmission characteristic of schizophrenia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DTNBP1
KW - dysbindin
KW - MUTED
KW - BLOC-1
KW - dopamine D2 receptor
KW - DRD2
KW - dopamine D1 receptor
KW - DRD1
KW - internalization
KW - endocytosis
KW - CREB
KW - schizophrenia
KW - 2007
KW - Animal Models
KW - Dopamine
KW - Neurotransmission
KW - Rats
KW - Schizophrenia
KW - Neural Receptors
KW - Proteins
KW - Ribonucleic Acid
KW - 2007
U1 - Sponsor: National Institutes of Health, National Institute of Mental Health, Intramural Research Program. Recipients: No recipient indicated
DO - 10.1523/JNEUROSCI.1689-07.2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19840-003&site=ehost-live&scope=site
UR - straubr@intra.nimh.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - FalI-Dickson, Jane M.
AU - Ramsay, Edward S.
AU - Castro, Kathleen
AU - Woltz, Patricia
AU - Sportés, Claude
T1 - Oral Mucositis-Related Oropharyngeal Pain and Correlative Tumor Necrosis Factor-α Expression in Adult Oncology Patients Undergoing Hematopoietic Stem Cell Transplantation
JO - Clinical Therapeutics
JF - Clinical Therapeutics
Y1 - 2007/11/02/Nov2007 Supplement 1
VL - 29
IS - 11
M3 - Article
SP - 2547
EP - 2561
SN - 01492918
AB - Abstract: Background: Oral mucositis is the most common sequela of conditioning chemotherapy (CT) for hematopoietic stem cell transplantation (HSCT) and is the principal cause of most of the associated pain. Tumor necrosis factor-α (TNF-α) is a key pathogenic component of oral mucositis. Objectives: The primary purpose of this study was to describe oral mucositis-related oropharyngeal pain in the setting of HSCT. A secondary purpose was to assess the effectiveness of molecular biology methods for measuring TNF-α concentrations in plasma, saliva, and buccal epithelial cells in patients with oral mucositis undergoing HSCT. Methods: This descriptive, correlative study recruited subjects aged ≥ 18 years who were scheduled to receive HSCT with CT. Subjects assessed their pain at baseline and 9 days (±24 hours) after CT using a pain visual analog scale (VAS) from 0 = no pain to 10 = worst possible pain, as well as word descriptors of sensory and affective pain. The extent and severity of oral mucositis were evaluated using the Oral Mucositis Assessment Scale. Saliva and blood samples and buccal brush biopsies were obtained at the same time points. Salivary and plasma TNF-**α concentrations were measured using an enzyme-linked immunosorbent assay. Quantitative real-time polymerase chain reaction testing was used to measure buccal TNF-α gene expression. To determine the optimal method of RNA isolation, samples were extracted using 3 different methods: TRIzol, RNeasy, and RLT/TRIzol. Results: Twenty-five adult men and women (mean age, 46 years; age range, 32-68 years; 64% white) underwent HSCT with CT. Significant differences from baseline to day 9 were observed in the severity of oral mucositis (P < 0.001), the overall intensity of oral pain (P < 0.05), the overall intensity of oral pain with swallowing (P < 0.01), the sensory dimension of oral pain with swallowing (P < 0.05), and the sensory and affective dimension of oral pain with swallowing (P < 0.05). The severity of oral mucositis was significantly associated with the overall intensity of oral pain (P < 0.05). Although mean scores for oral pain were low, 8 subjects had clinically unacceptable pain VAS scores (>3) while receiving opioids. Fourteen subjects had measurable increases in buccal TNF-α RNA expression at day 9 (P = 0.027 vs baseline), as measured using the TRIzol method, which was found to be the best method for measuring this variable. TNF-α RNA content in buccal samples was significantly associated with the worst intensity of oral pain with swallowing (partial R2 = 0.19; P < 0.05). Conclusions: Despite the use of opioids, oropharyngeal pain remained a treatment challenge in approximately one third of these subjects after CT with HSCT. The sensitive assay used to measure TNF-α gene expression in buccal cells may be useful in investigating molecular events in oral mucositis-related pain, as well as in evaluating the therapeutic response to investigational agents. [Copyright &y& Elsevier]
AB - Copyright of Clinical Therapeutics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - TUMOR necrosis factor
KW - MOLECULAR biology
KW - CELL transplantation
N1 - Accession Number: 28117823; FalI-Dickson, Jane M. 1; Email Address: dicksonj@mail.nih.gov Ramsay, Edward S. 2 Castro, Kathleen 3 Woltz, Patricia 1,4 Sportés, Claude 5; Affiliation: 1: Mucosal Injury Unit, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland 2: Laboratory of Symptom Management, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland 3: Clinical Center, Nursing and Patient Care Services, Research and Practice Development Service, National Institutes of Health, Bethesda, Maryland 4: Current affiliation: Office of Surveillance and Biometrics, Center for Devices and Radiological Health, US Food and Drug Administration, Bethesda, Maryland. 5: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Source Info: Nov2007 Supplement 1, Vol. 29 Issue 11, p2547; Subject Term: RESEARCH; Subject Term: TUMOR necrosis factor; Subject Term: MOLECULAR biology; Subject Term: CELL transplantation; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.clinthera.2007.12.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28117823&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arnsten, Julia H.
AU - Xuan Li
AU - Mizuno, Yuko
AU - Knowlton, Amy R.
AU - Gourevitch, Marc N.
AU - Handley, Kathleen
AU - Knight, Kelly R.
AU - Metsch, Lisa R.
T1 - Factors Associated With Anti retroviral Therapy Adherence and Medication Errors Among HIV-Infected Injection Drug Users.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2007/11/02/11/1/2007 Supplement
VL - 46
IS - S2
M3 - Article
SP - S64
EP - S71
SN - 15254135
AB - The article discusses the factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users (IDUs). It suggests that the modifiable factors associated with poor adherence, including depressive symptoms and poor self-efficacy, should be targeted for intervention. It concludes that interventions should include particular efforts to identify medication taking inconsistent with antiretroviral prescriptions.
KW - ANTIRETROVIRAL agents
KW - RESEARCH
KW - PATIENT compliance
KW - HIV-positive persons
KW - SELF-efficacy
KW - DRUGS
KW - MEDICATION errors
KW - RETROVIRUS diseases
KW - adherence
KW - antiretrovirals
KW - HIV
KW - injection drug use
KW - medication errors
N1 - Accession Number: 27598515; Arnsten, Julia H. 1; Email Address: jarflsten@montefiore.org Xuan Li 1 Mizuno, Yuko 2 Knowlton, Amy R. 3 Gourevitch, Marc N. 4 Handley, Kathleen 5 Knight, Kelly R. 6 Metsch, Lisa R. 7; Affiliation: 1: Division of General Internal Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 2: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 3: Department of Health, Behavior and Society, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 4: Division of General Internal Medicine, Department of Medicine, New York University School of Medicine, New York, NY 5: Health Resources and Services Administration Global AIDS Program, Rockville, MD 6: Department of Medicine, University of California at San Francisco, San Francisco, CA 7: Department of Epidemiology and Public Health, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Source Info: 11/1/2007 Supplement, Vol. 46 Issue S2, pS64; Subject Term: ANTIRETROVIRAL agents; Subject Term: RESEARCH; Subject Term: PATIENT compliance; Subject Term: HIV-positive persons; Subject Term: SELF-efficacy; Subject Term: DRUGS; Subject Term: MEDICATION errors; Subject Term: RETROVIRUS diseases; Author-Supplied Keyword: adherence; Author-Supplied Keyword: antiretrovirals; Author-Supplied Keyword: HIV; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: medication errors; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27598515&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arnsten, Julia H.
AU - Xuan Li
AU - Mizuno, Yuko
AU - Knowlton, Amy R.
AU - Gourevitch, Marc N.
AU - Handley, Kathleen
AU - Knight, Kelly R.
AU - Metsch, Lisa R.
T1 - Factors Associated With Anti retroviral Therapy Adherence and Medication Errors Among HIV-Infected Injection Drug Users.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2007/11/02/11/1/2007 Supplement
VL - 46
IS - S2
M3 - Article
SP - S64
EP - S71
SN - 15254135
AB - The article discusses the factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users (IDUs). It suggests that the modifiable factors associated with poor adherence, including depressive symptoms and poor self-efficacy, should be targeted for intervention. It concludes that interventions should include particular efforts to identify medication taking inconsistent with antiretroviral prescriptions.
KW - ANTIRETROVIRAL agents -- Research
KW - PATIENT compliance
KW - HIV-positive persons
KW - SELF-efficacy
KW - DRUGS
KW - MEDICATION errors
KW - RETROVIRUS diseases
KW - adherence
KW - antiretrovirals
KW - HIV
KW - injection drug use
KW - medication errors
N1 - Accession Number: 27598515; Arnsten, Julia H. 1; Email Address: jarflsten@montefiore.org; Xuan Li 1; Mizuno, Yuko 2; Knowlton, Amy R. 3; Gourevitch, Marc N. 4; Handley, Kathleen 5; Knight, Kelly R. 6; Metsch, Lisa R. 7; Source Information: 11/1/2007 Supplement, Vol. 46 Issue S2, pS64; Subject: ANTIRETROVIRAL agents -- Research; Subject: PATIENT compliance; Subject: HIV-positive persons; Subject: SELF-efficacy; Subject: DRUGS; Subject: MEDICATION errors; Subject: RETROVIRUS diseases; Author-Supplied Keyword: adherence; Author-Supplied Keyword: antiretrovirals; Author-Supplied Keyword: HIV; Author-Supplied Keyword: injection drug use; Author-Supplied Keyword: medication errors; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=27598515&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rock, Edwin P.
AU - Scott, Jane A.
AU - Kennedy, Dianne L.
AU - Sridhara, Raheshwari
AU - Pazdur, Richard
AU - Burke, Laurie B.
T1 - Challenges to Use of Health-Related Quality of Life for Food and Drug Administration Approval of Anticancer Products.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2007/11/02/2007 Monographs Supplement
IS - 37
M3 - Article
SP - 27
EP - 30
SN - 00278874
AB - The U.S. Food and Drug Administration (FDA) approves labeling claims of drug efficacy based on substantial evidence of clinical benefit demonstrated in adequate and well-controlled investigations. Patient-reported outcomes (PROs) may support marketing claims of clinical benefit, either alone or with other study endpoints. Health-related quality of life (HRQL) is a PRO that comprehensively measures patients' reported health status. We present an overview of why HRQL-based efficacy claims have not to date been accepted by the FDA for inclusion in anticancer product labels. Persistent challenges to allowance of such claims include shortcomings in randomization and blinding of clinical trials, missing data, statistical multiplicity, and unclear intrinsic meaning of selected HRQL findings. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Effectiveness
KW - QUALITY of life
KW - ANTINEOPLASTIC agents
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 27599416; Rock, Edwin P. 1 Scott, Jane A. 2 Kennedy, Dianne L. 2 Sridhara, Raheshwari 3 Pazdur, Richard 1 Burke, Laurie B. 2; Email Address: laurie.burke@fda.hhs.gov; Affiliation: 1: Office of Oncology Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 2: Study Endpoints and Lavel Development Team, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 3: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 2007 Monographs Supplement, Issue 37, p27; Subject Term: DRUGS -- Effectiveness; Subject Term: QUALITY of life; Subject Term: ANTINEOPLASTIC agents; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1093/jncimonofraphs/lgm06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27599416&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105930249
T1 - Improving the health care work environment: a sociotechnical systems approach.
AU - Harrison MI
AU - Henriksen K
AU - Hughes RG
Y1 - 2007/11/02/2007 Nov Supplement
N1 - Accession Number: 105930249. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2007 Nov Supplement. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 101238023.
KW - Work Environment
KW - Patient Safety
KW - Quality of Health Care
SP - 3
EP - 6
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 33
IS - 11
CY - Oak Brook, Illinois
PB - Joint Commission Resources
SN - 1553-7250
AD - Senior Research Scientist -- Organizations and Systems, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland; Michael.Harrison@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105930256
T1 - The role of the physical environment in crossing the quality chasm.
AU - Henriksen K
AU - Isaacson S
AU - Sadler BL
AU - Zimring CM
Y1 - 2007/11/02/2007 Nov Supplement
N1 - Accession Number: 105930256. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Supplement Title: 2007 Nov Supplement. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Patient Safety; Quality Assurance. NLM UID: 101238023.
KW - Health Facility Environment
KW - Patient Safety
KW - Quality of Health Care
KW - Access to Information
KW - Accidental Falls -- Prevention and Control
KW - Cross Infection -- Prevention and Control
KW - Family
KW - Institute of Medicine (U.S.)
KW - Lighting
KW - Noise
KW - Occupational Safety
KW - Patient Centered Care
KW - Patient Classification
KW - Patients' Rooms
KW - Productivity
KW - Time Factors
KW - Transfer, Discharge
SP - 68
EP - 80
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 33
IS - 11
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - Background: Evidence-based design findings are available to help inform hospital decision makers of opportunities for ensuring that quality and safety are designed into new and refurbished facilities.Framework for the Evidence: The Institute of Medicine's six quality aims of patient centeredness, safety, effectiveness, efficiency, timeliness, and equity provide an organizing framework for introducing a representative portion of the evidence. Design improvements include single-bed and variable-acuity rooms; electronic access to medical records; greater accommodation for families and visitors; handrails to prevent patient falls; standardization (room layout, equipment, and supplies for improved efficiencies); improved work process flow to reduce delays and wait times; and better assessment of changing demographics, disease conditions, and community needs for appropriately targeted health care services.The Business Case: A recent analysis of the business case suggests that a slight, one-time incremental cost for ensuring safety and quality would be paid back in two to three years in the form of operational savings and increased revenues. Hospitals leaders anticipating new construction projects should take advantage of evidence-based design findings that have the potential of raising the quality of acute care for decades to come.
SN - 1553-7250
AD - Human Factors Advisor for Patient Safety, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland; Kerm.Henriksen@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105930255
T1 - Improving the health care work environment: implications for research, practice, and policy.
AU - Harrison MI
AU - Henriksen K
AU - Hughes RG
Y1 - 2007/11/02/2007 Nov Supplement
N1 - Accession Number: 105930255. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2007 Nov Supplement. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 101238023.
KW - Work Environment
KW - Bed Occupancy
KW - Nursing Management
KW - Occupational Safety
KW - Patient Safety
KW - Personnel Staffing and Scheduling
KW - Quality of Health Care
SP - 81
EP - 84
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 33
IS - 11
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - Future Research: Despite the gains to date, we need better understanding of practices for implementing and sustaining improvements in health care work environments and further study of organizational conditions affecting implementation of improvements.Practice: Limiting work hours, improving schedules, and providing sleep hygiene training will help combat clinician fatigue. Hospital crowding can be reduced through systemwide improvement of patient flow and capacity management, coupled with management support, measurement, and reporting on crowding. Long-term solutions to nurse staffing shortfalls include process redesign to enhance efficiency. Improvement of organizational climate, human resource management, and interoccupational relations will also contribute to staff retention. Evidence-based enhancements to patient rooms and other physical features in hospitals contribute directly to safety and quality and also affect staff performance.Policy: Landrigan and his colleagues call for external restrictions on residents' work shifts. Clarke examines prospects for mandated nursing-staff ratios. Public reporting on staffing, crowding, and other risks may incent change. Reporting and pay for performance require standardized measures of targeted conditions. Organizations promoting care quality can help spread safe work practices; they can also support collaborative learning and other strategies that may enhance implementation of improvements in work environments.
SN - 1553-7250
AD - Senior Research Scientist -- Organizations and Systems, Center for Delivery, Organizations, and Markets, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland; Michael.Harrison@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Patrick, Donald L.
AU - Burke, Laurie B.
AU - Powers, John H.
AU - Scott, Jane A.
AU - Rock, Edwin P.
AU - Dawisha, Sahar
AU - O'Neill, Robert
AU - Kennedy, Dianne L.
T1 - Patient-Reported Outcomes to Support Medical Product Labeling Claims: FDA Perspective.
JO - Value in Health
JF - Value in Health
Y1 - 2007/11/02/Nov2007 Supplement 2
VL - 10
M3 - Article
SP - S125
EP - S137
PB - Elsevier Science
SN - 15244733
AB - This article concerns development and use of patient-reported outcomes (PROs) in clinical trials to evaluate medical products. A PRO is any report coming directly from patients, without interpretation by physicians or others, about how they function or feel in relation to a health condition and its therapy. PRO instruments are used to measure these patient reports. PROs provide a unique perspective on medical therapy, because some effects of a health condition and its therapy are known only to patients. Properly developed and evaluated PRO instruments also have the potential to provide more sensitive and specific measurements of the effects of medical therapies, thereby increasing the efficiency of clinical trials that attempt to measure the meaningful treatment benefits of those therapies. Poorly developed andevaluated instruments may provide misleading conclusions or data that cannot be used to support product labeling claims. We review selected major challenges from Food and Drug Administration's perspective in using PRO instruments, measures, and end points to support treatment benefit claims in product labeling. These challenges highlight the need for sponsors to formulate desired labeling claim(s) prospectively, to acquire and document information needed to support these claim(s), and to identify existing instruments or develop new and more appropriate PRO instruments for evaluating treatment benefit in the defined population in which they will seek claims. [ABSTRACT FROM AUTHOR]
AB - Copyright of Value in Health is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATIENTS
KW - MEDICAL records
KW - CLINICAL trials
KW - THERAPEUTICS
KW - DRUGS
KW - PHYSICIANS
KW - DIAGNOSIS
KW - clinical trials
KW - FDA
KW - patient-reported outcomes
KW - PRO
KW - QOL
KW - statistical analysis
N1 - Accession Number: 27414586; Patrick, Donald L. 1; Email Address: donald@u.washington.edu Burke, Laurie B. 2 Powers, John H. 3 Scott, Jane A. 4 Rock, Edwin P. 5 Dawisha, Sahar 6 O'Neill, Robert 7 Kennedy, Dianne L. 2; Affiliation: 1: Special Government Employee, Food and Drug Administration and Professor, University ofWashington, Seattle Quality of Life Group, Seattle,WA, USA 2: Study Endpoints and Label Development Team, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA 3: Scientific Applications International Corporation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA 4: Mapi Values Ltd, Cheshire, UK 5: GSK Biologicals, Collegeville, PA, USA 6: Division of General, Restorative, and Neurological Devices, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA 7: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Source Info: Nov2007 Supplement 2, Vol. 10, pS125; Subject Term: PATIENTS; Subject Term: MEDICAL records; Subject Term: CLINICAL trials; Subject Term: THERAPEUTICS; Subject Term: DRUGS; Subject Term: PHYSICIANS; Subject Term: DIAGNOSIS; Author-Supplied Keyword: clinical trials; Author-Supplied Keyword: FDA; Author-Supplied Keyword: patient-reported outcomes; Author-Supplied Keyword: PRO; Author-Supplied Keyword: QOL; Author-Supplied Keyword: statistical analysis; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 1p; Illustrations: 1 Diagram, 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1524-4733.2007.00275.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105836069
T1 - Patient-reported outcomes to support medical product labeling claims: FDA perspective.
AU - Patrick DL
AU - Burke LB
AU - Powers JH
AU - Scott JA
AU - Rock EP
AU - Dawisha S
AU - O'Neill R
AU - Kennedy DL
Y1 - 2007/11/02/Nov2007 Supplement 2
N1 - Accession Number: 105836069. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: Nov2007 Supplement 2. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100883818.
KW - Clinical Trials
KW - Data Collection Methods
KW - Patient Satisfaction -- Statistics and Numerical Data
KW - Product Labeling -- Standards
KW - Treatment Outcomes
KW - Biological Assay
KW - Data Collection
KW - Product Labeling -- Statistics and Numerical Data
KW - Psychometrics
KW - Reproducibility of Results
KW - United States
KW - Human
SP - S125
EP - 37
JO - Value in Health
JF - Value in Health
JA - VALUE HEALTH
VL - 10
CY - New York, New York
PB - Elsevier Science
SN - 1524-4733
AD - Food and Drug Administration, University of Washington, Seattle Quality of Life Group, Seattle, WA 98103-8652, USA. donald@u.washington.edu
U2 - PMID: 17995471.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105932449
T1 - Clinical guidelines. Management of stable chronic obstructive pulmonary disease: a systematic review for a clinical practice guideline.
AU - Wilt TJ
AU - Niewoehner D
AU - MacDonald R
AU - Kane RL
Y1 - 2007/11/06/
N1 - Accession Number: 105932449. Language: English. Entry Date: 20080118. Revision Date: 20150711. Publication Type: Journal Article; CEU; consumer/patient teaching materials; research; systematic review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. Grant Information: AHRQ contract no. 290-02-0009 and a contract with the American College of Physicians. NLM UID: 0372351.
KW - Pulmonary Disease, Chronic Obstructive -- Diagnosis
KW - Pulmonary Disease, Chronic Obstructive -- Drug Therapy
KW - Administration, Inhalation
KW - Cochrane Library
KW - Confidence Intervals
KW - Disease Management
KW - Education, Continuing (Credit)
KW - Funding Source
KW - Pulmonary Disease, Chronic Obstructive -- Physiopathology
KW - Oxygen Therapy
KW - Patient Education
KW - PubMed
KW - Rehabilitation, Pulmonary
KW - Systematic Review
KW - Human
SP - 639
EP - I41
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 9
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common and disabling condition in adults. Information about therapeutic effectiveness and adverse effects of common treatment options and how clinical and spirometric characteristics affect outcomes is not well known but is important for clinicians caring for patients with stable COPD. PURPOSE: To evaluate the effectiveness of COPD management strategies. DATA SOURCES: English-language publications in MEDLINE and the Cochrane Library through March 2007. STUDY SELECTION: Randomized, controlled trials (RCTs) and previous systematic reviews of inhaled therapies, pulmonary rehabilitation, disease management, and supplemental oxygen in adults with COPD. DATA EXTRACTION: Participant, study, and intervention characteristics; exacerbations; deaths; respiratory health status; exercise capacity; hospitalizations; and adverse effects. DATA SYNTHESIS: Eight meta-analyses and 42 RCTs examined inhaled therapies: short-acting anticholinergics (n = 7), long-acting anticholinergics (n = 10), long-acting beta2-agonists (n = 22), corticosteroids (n = 14), dual D2 dopamine receptor-beta2-agonist (n = 3), or short-acting beta2-agonist plus ipratropium (n = 3). Evidence for nonpharmacologic therapies included 3 reviews of 39 RCTs plus 6 additional RCTs of pulmonary rehabilitation, 2 reviews of 13 RCTs plus 2 additional RCTs of disease management, and 8 RCTs of oxygen. Overall, long-acting inhaled therapies, used alone or in combination, reduced exacerbations more than placebo by 13% to 25% and had similar effectiveness to each other. Average improvements in health status scores were less than what is considered to be clinically noticeable. Inhaled monotherapy did not reduce mortality rates. Inhaled corticosteroids plus long-acting beta2-agonists reduced deaths in relative terms compared with placebo (relative risk, 0.82 [95% CI, 0.69 to 0.98]) and inhaled corticosteroids alone (relative risk, 0.79 [CI, 0.67 to 0.94]) but not compared with long-acting beta2-agonists alone (relative risk, 0.82 [CI, 0.52 to 1.28]). Absolute reductions were 1% or less and were not statistically significant. Pulmonary rehabilitation improved health status and dyspnea but not walking distance. Neither disease management nor ambulatory oxygen improved measured outcomes. Supplemental oxygen reduced mortality rates among symptomatic patients with resting hypoxia (relative risk, 0.61 [CI, 0.46 to 0.82]). Insufficient evidence supports using spirometry to guide therapy. LIMITATIONS: Articles were limited to those in the English language. Treatment adherence, adverse effects, and effectiveness may differ among clinical settings. Short-acting inhalers for 'rescue therapy' were not evaluated. CONCLUSION: Long-acting inhaled therapies, supplemental oxygen, and pulmonary rehabilitation are beneficial in adults who have bothersome respiratory symptoms, especially dyspnea, and FEV1 less than 60% predicted.
SN - 0003-4819
AD - Minnesota Agency for Healthcare Research and Quality Evidence-based Practice Center, Minneapolis Veterans Affairs Medical Center, and University of Minnesota, Minneapolis, Minnesota 55417, USA; tim.wilt@med.va.gov
U2 - PMID: 17975187.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105892337
T1 - Needle-stick injuries in primary care in Wales.
AU - Atenstaedt RL
AU - Payne S
AU - Roberts RJ
AU - Russell IT
AU - Russell D
AU - Edwards RT
Y1 - 2007/11/12/
N1 - Accession Number: 105892337. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 101188638.
KW - Family Practice
KW - Needlestick Injuries -- Epidemiology
KW - Primary Health Care -- Utilization
KW - Family Practice -- Standards
KW - Family Practice -- Statistics and Numerical Data
KW - Logistic Regression
KW - Needlestick Injuries -- Therapy
KW - Organizational Policies
KW - Practice Guidelines
KW - Primary Health Care -- Administration
KW - Primary Health Care -- Standards
KW - Private Practice Management
KW - Surveys
KW - Wales
KW - Human
SP - 434
EP - 440
JO - Journal of Public Health
JF - Journal of Public Health
JA - J PUBLIC HEALTH
VL - 29
IS - 4
PB - Oxford University Press / USA
AB - BACKGROUND: Accidental needle-stick injuries (NSIs) are a hazard for health-care workers and for the general public. OBJECTIVES: To estimate the presentation rate of NSIs to general medical practices, their relation to practice characteristics, and review practice policies for managing NSIs. METHOD: Descriptive study using logistic regression analysis. RESULTS: Annual rates of 2.73 (95% CI 2.08, 3.50) occupational NSIs per 100 clinical practice staff and 2.14 (95% CI 1.39, 3.13) non-occupational NSIs per 100 000 practice population were recorded. Stepwise logistic regressions showed that chance of a practice reporting at least one occupational NSI in previous five years was best predicted by being a single-handed practice (decreased odds). In contrast, the chance of a practice reporting at least one non-occupational NSI was best predicted by being a rural practice (increased odds). About one in five practices possessed no written policy on managing NSIs. Stepwise logistic regressions showed that the chance of a practice owning a NSI policy was best predicted by being located in an LHB area with a coastline (increased odds). CONCLUSION: NSIs are an important public health issue in Wales. We have tried to address the lack of guidance by developing new guidelines in Wales.
SN - 1741-3842
AD - National Public Health Service for Wales, UK.
U2 - PMID: 17998261.
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ER -
TY - JOUR
AU - Marutyan, Karen R.
AU - Anderson, Christian C.
AU - Wear, Keith A.
AU - Holland, Mark R.
AU - Miller, James G.
AU - Bretthorst, G. Larry
T1 - PARAMETER ESTIMATION IN ULTRASONIC MEASUREMENTS ON TRABECULAR BONE.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2007/11/13/
VL - 954
IS - 1
M3 - Article
SP - 329
EP - 336
PB - American Institute of Physics
SN - 0094243X
AB - Ultrasonic tissue characterization has shown promise for clinical diagnosis of diseased bone (e.g., osteoporosis) by establishing correlations between bone ultrasonic characteristics and the state of disease. Porous (trabecular) bone supports propagation of two compressional modes, a fast wave and a slow wave, each of which is characterized by an approximately linear-with-frequency attenuation coefficient and monotonically increasing with frequency phase velocity. Only a single wave, however, is generally apparent in the received signals. The ultrasonic parameters that govern propagation of this single wave appear to be causally inconsistent [1]. Specifically, the attenuation coefficient rises approximately linearly with frequency, but the phase velocity exhibits a decrease with frequency. These inconsistent results are obtained when the data are analyzed under the assumption that the received signal is composed of one wave. The inconsistency disappears if the data are analyzed under the assumption that the signal is composed of superposed fast and slow waves. In the current investigation, Bayesian probability theory is applied to estimate the ultrasonic characteristics underlying the propagation of the fast and slow wave from computer simulations. Our motivation is the assumption that identifying the intrinsic material properties of bone will provide more reliable estimates of bone quality and fracture risk than the apparent properties derived by analyzing the data using a one-mode model. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARAMETER estimation
KW - DIAGNOSTIC ultrasonic imaging
KW - BONES -- Wounds & injuries
KW - POROUS materials
KW - PROBABILITY theory
KW - Bayesian probability theory
KW - bone
KW - osteoporosis
KW - tissue characterization
KW - ultrasound
N1 - Accession Number: 27500903; Marutyan, Karen R. 1 Anderson, Christian C. 2 Wear, Keith A. 3 Holland, Mark R. 2 Miller, James G. 2 Bretthorst, G. Larry 1; Affiliation: 1: Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 63110 2: Laboratory For Ultrasonics, Department of Physics, Washington University, St. Louis, MO 63130 3: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993; Source Info: 11/13/2007, Vol. 954 Issue 1, p329; Subject Term: PARAMETER estimation; Subject Term: DIAGNOSTIC ultrasonic imaging; Subject Term: BONES -- Wounds & injuries; Subject Term: POROUS materials; Subject Term: PROBABILITY theory; Author-Supplied Keyword: Bayesian probability theory; Author-Supplied Keyword: bone; Author-Supplied Keyword: osteoporosis; Author-Supplied Keyword: tissue characterization; Author-Supplied Keyword: ultrasound; Number of Pages: 8p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1063/1.2821279
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Christian C.
AU - Marutyan, Karen R.
AU - Wear, Keith A.
AU - Holland, Mark R.
AU - Miller, James G.
AU - Bretthorst, G. Larry
T1 - Model Selection in Ultrasonic Measurements on Trabecular Bone.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2007/11/13/
VL - 954
IS - 1
M3 - Article
SP - 337
EP - 345
PB - American Institute of Physics
SN - 0094243X
AB - Previous work from our laboratory showed that the widely reported decrease in phase velocity with frequency (negative dispersion) for ultrasonic waves propagating through trabecular bone can arise from the interference of two compressional waves, each of which exhibits a positive dispersion. Previous simulations suggest that Bayesian probability theory can be employed to recover the material properties linked to these two interfering waves, even when the waves overlap sufficiently that visual inspection cannot distinguish two modes. In the present study, Bayesian probability theory is applied first to simulated data and then to representative experimental bone data to determine whether one or two compressional wave modes are present. Model selection is implemented by evaluating the posterior probability for each model. The calculation is implemented by defining a model indicator and then using Markov chain Monte Carlo with simulated annealing to draw samples from the joint posterior probability for the ultrasonic parameters and the model indicator. Monte Carlo integration is used to evaluate the marginal posterior probability for each parameter given the model indicator. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SIMULATED annealing (Mathematics)
KW - ULTRASONIC imaging
KW - MONTE Carlo method
KW - MARKOV processes
KW - COMBINATORIAL optimization
KW - Bayesian probability theory
KW - bone
KW - model selection
KW - osteoporosis
KW - tissue characterization
KW - ultrasound
N1 - Accession Number: 27500902; Anderson, Christian C. 1 Marutyan, Karen R. 2 Wear, Keith A. 3 Holland, Mark R. 1 Miller, James G. 1 Bretthorst, G. Larry 2; Affiliation: 1: Laboratory For Ultrasonics, Department of Physics, Washington University, St. Louis, MO 63130 2: Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO 63110 3: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993; Source Info: 11/13/2007, Vol. 954 Issue 1, p337; Subject Term: SIMULATED annealing (Mathematics); Subject Term: ULTRASONIC imaging; Subject Term: MONTE Carlo method; Subject Term: MARKOV processes; Subject Term: COMBINATORIAL optimization; Author-Supplied Keyword: Bayesian probability theory; Author-Supplied Keyword: bone; Author-Supplied Keyword: model selection; Author-Supplied Keyword: osteoporosis; Author-Supplied Keyword: tissue characterization; Author-Supplied Keyword: ultrasound; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1063/1.2821280
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reipa, Vytas
AU - Holden, Marcia J.
AU - Vilker, Vincent L.
T1 - Association and Redox Properties of the Putidaredoxin Reductase—Nicotinamide Adenine Dinucleotide Complex.
JO - Biochemistry
JF - Biochemistry
Y1 - 2007/11/13/
VL - 46
IS - 45
M3 - Article
SP - 13235
EP - 13244
SN - 00062960
AB - Putidaredoxin reductase (PdR) is the flavin protein that carries out the first electron transfer involved in the cytochrome P450cam catalytic cycle. In PdR, the flavin adenine dinucleotide (FAD/FADH2) redox center acts as a transformer by accepting two electrons from soluble nicotinamide adenine dinucleotide (NAD+/NADH) and donating them in two separate, one-electron-transfer steps to the iron—sulfur protein putidaredoxin (Pdx). PdR, like the two more intensively studied monoflavin reductases, adrenodoxin reductase (AdR) and ferredoxin—NADP+ reductase (FNR), has no other active redox moieties (e.g., sulfhydryl groups) and can exist in three different oxidation states: (i) oxidized quinone, (ii) one-electron reduced semiquinone (stable neutral species (blue) or unstable radical anion (red)), and (iii) two-electron fully reduced hydroquinone. Here, we present reduction potential measurements for PdR in support of a thermodynamic model for the modulation of equilibria among the redox components in this initial electron-transfer step of the P450 cycle. A spectroelectrochemical technique was used to measure the midpoint oxidation—reduction potential of PdR that had been carefully purified of all residual NAD+, E0' = -369 ± 10 mV at pH 7.6, which is more negative than previously reported and more negative than the pyridine nucleotide NADH/NAD+ (-330 mV). After addition of NAD+, the formation of the oxidized reductase-oxidized pyridine nucleotide complex was followed by the two-electron-transfer redox reaction, PdRox:NAD+ + 2e- → PdRrd:NAD+, when the electrode potential was lowered. The midpoint potential was a hyperbolic function of increasing NAD+ concentration, such that at concentrations of pyridine nucleotide typically found in an intracellular environment, the midpoint potential would be E0' = -230 ± 10 mV, thereby providing the thermodynamically favorable redox equilibria that enables electron transfer from NADH. This thermodynamic control of electron transfer is a shared mechanistic feature with the adrenodoxin P450 and photosynthetic electron-transfer systems but is different from the kinetic control mechanisms in the microsomal P450 systems where multiple reaction pathways draw on reducing power held by NADPH—cytochrome P450 reductase. The redox measurements were combined with protein fluorescence quenching of NAD+ binding to oxidized PdR to establish that the PdRox:NAD+ complex (KD = 230 μM) is about 5 orders of magnitude weaker than PdRrd:NAD+ binding. These results are integrated with known structural and kinetic information for PdR, as well as for AdR and FNR, in support of a compulsory ordered pathway to describe the electron-transfer processes catalyzed by all three reductases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL research
KW - OXIDATION-reduction reaction
KW - FLAVINS
KW - FLAVOPROTEINS
KW - CHARGE exchange
KW - CYTOCHROMES
N1 - Accession Number: 27582078; Reipa, Vytas 1 Holden, Marcia J. 1 Vilker, Vincent L. 1,2,3; Email Address: Vincent.Vilker@fda.hhs.gov; Affiliation: 1: National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 2: Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 3: U.S. Food and Drug Administration, White Oak Building 22, Room 2130, 10903 New Hampshire Avenue, Silver Spring, Maryland; Source Info: 11/13/2007, Vol. 46 Issue 45, p13235; Subject Term: BIOCHEMICAL research; Subject Term: OXIDATION-reduction reaction; Subject Term: FLAVINS; Subject Term: FLAVOPROTEINS; Subject Term: CHARGE exchange; Subject Term: CYTOCHROMES; Number of Pages: 10p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gudlavalleti, Seshu K.
AU - Lee, Che-Hung
AU - Norris, Scott E.
AU - Paul-Satyaseela, Maneesh
AU - Vann, Willie F.
AU - Frasch, Carl E.
T1 - Comparison of Neisseria meningitidis serogroup W135 polysaccharide–tetanus toxoid conjugate vaccines made by periodate activation of O-acetylated, non-O-acetylated and chemically de-O-acetylated polysaccharide
JO - Vaccine
JF - Vaccine
Y1 - 2007/11/14/
VL - 25
IS - 46
M3 - Article
SP - 7972
EP - 7980
SN - 0264410X
AB - Abstract: Polysaccharide (PS) and tetanus toxoid (TT) protein conjugate vaccines were prepared using O-acetylated (OAc+), O-acetyl negative (OAc−) and chemically de-O-acetylated (de-OAc) meningococcal W135 PS. The PSs were activated by periodate oxidation and coupled to hydrazine derivatized TT. High performance anion exchange chromatography of acid hydrolysates of periodate activated W135 PSs, showed that galactose residues in OAc+ PS were more sensitive to the periodate oxidation step than they were in the OAc− PS or de-OAc PS. Mouse antisera against OAc−-TT conjugate vaccines recognized both OAc− and OAc+ PS by ELISAs and had high bactericidal titers against both OAc+ and OAc− W135 strains. Purified high molecular weight (HMW) conjugates showed higher PS to protein ratios in OAc−-TT(HMW) and de-OAc-TT(HMW) indicating better conjugation efficiency than OAc+-TT(HMW) conjugate. Antisera against the HMW fractions gave higher bactericidal titers than antisera against unfractionated conjugates. Inhibition ELISAs indicated that OAc− and OAc+ HMW conjugates induced antibodies that bound both OAc+ and OAc− PS. Thus, for W135, PS O-acetylation does not contribute a dominant immunogenic epitope. The OAc− PS may be a good starting material for preparing W135 PS–TT conjugate vaccines using periodate oxidation. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polysaccharides
KW - Biopolymers
KW - Anaerobic infections
KW - Vaccines
KW - Conjugate vaccines
KW - Neisseria meningitidis serogroup W135
KW - Polysaccharide O-acetylation
N1 - Accession Number: 27243856; Gudlavalleti, Seshu K.; Email Address: gudlavalletis@yahoo.com; Lee, Che-Hung 1; Norris, Scott E. 1; Paul-Satyaseela, Maneesh 1; Vann, Willie F. 1; Frasch, Carl E. 1; Affiliations: 1: Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, MD, USA; Issue Info: Nov2007, Vol. 25 Issue 46, p7972; Thesaurus Term: Polysaccharides; Subject Term: Biopolymers; Subject Term: Anaerobic infections; Subject Term: Vaccines; Author-Supplied Keyword: Conjugate vaccines; Author-Supplied Keyword: Neisseria meningitidis serogroup W135; Author-Supplied Keyword: Polysaccharide O-acetylation; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.06.018
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frazar, Christian D.
AU - Orlandi, Palmer A.
T1 - Evaluation of Two DNA Template Preparation Methods for Post-Immunomagnetic Separation Detection of Ciyptosporidium parvum in Foods and Beverages by PCR.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/11/15/
VL - 73
IS - 22
M3 - Article
SP - 7474
EP - 7476
SN - 00992240
AB - Cryptosporidium parvum oocysts were recovered by immunomagnetic separation from six artificially contaminated foods. Two DNA isolation methods were subsequently evaluated by PCR. The FTA Concentrator-PS filter provided rapid and reproducible detection, although variability increased at lower inoculum levels (88% and 15% detection in high- and low-inoculum-level samples, respectively). Total DNA extraction generated consistent results at all oocyst levels but resulted in longer analysis time (100% and 59% detection in high- and low-inoculum-level samples, respectively). Also reflected in this study was that the matrix played an important role in the ability to recover oocysts, as sample turbidity, pH, and PCR inhibitors all influenced detection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD contamination
KW - CRYPTOSPORIDIUM parvum
KW - HYDROGEN-ion concentration
KW - DNA
KW - NUCLEIC acids
KW - POLYMERASE chain reaction
N1 - Accession Number: 27739895; Frazar, Christian D. 1 Orlandi, Palmer A. 1; Email Address: palmer.orlandi@fda.hhs.gov; Affiliation: 1: Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland 20708; Source Info: Nov2007, Vol. 73 Issue 22, p7474; Subject Term: FOOD contamination; Subject Term: CRYPTOSPORIDIUM parvum; Subject Term: HYDROGEN-ion concentration; Subject Term: DNA; Subject Term: NUCLEIC acids; Subject Term: POLYMERASE chain reaction; Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.01652-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27739895&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sutton, Madeline
AU - Sternberg, Maya
AU - Koumans, Emilia H.
AU - McQuillan, Geraldine
AU - Berman, Stuart
AU - Markowitz, Lauri
T1 - The Prevalence of Trichomonas vaginalis Infection among Reproductive-Age Women in the United States, 2001–2004.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/11/15/
VL - 45
IS - 10
M3 - Article
SP - 1319
EP - 1325
SN - 10584838
AB - Background. Trichomonas vaginalis infection is a common sexually transmitted protozoal infection and is associated with several adverse health outcomes, such as preterm birth, delivery of a low-birth weight infant, and facilitation of sexual transmission of human immunodeficiency virus. The annual incidence in the United States has been estimated to be 3–5 million cases. However, there are no data on the prevalence of trichomoniasis among all reproductive-age women. We estimated the prevalence of T. vaginalis infection from a nationally representative sample of women in the United States. Methods. Women aged 14–49 years who participated in the National Health and Examination Survey cycles for 2001–2004 provided self-collected vaginal swab specimens. The vaginal fluids extracted from these swabs were evaluated for the presence of T. vaginalis using polymerase chain reaction. Results. Overall, 3754 (81%) of 4646 women provided swab specimens. The prevalence of T. vaginalis infection was 3.1% (95% confidence interval [CI], 2.3%–4.3%); for non-Hispanic white women, it was 1.3% (95% CI, 0.7%–2.3%); for Mexican American women, it was 1.8% (95% CI, 0.9%–3.7%); and for non-Hispanic black women, it was 13.3% (95% CI, 10.0%–17.7%). Factors that remained associated with increased likelihood of T. vaginalis infection in multivariable analyses included non-Hispanic black race/ethnicity, being born in the United States, a greater number of lifetime sex partners, increasing age, lower educational level, poverty, and douching. Conclusions. The prevalence of T. vaginalis infection among women in the United States was 3.1%. A significant racial disparity exists; the prevalence among non-Hispanic black women was 10.3 times higher than that among non-Hispanic white and Mexican American women. Optimal prevention and control strategies for T. vaginalis infection should be explored as a means of closing the racial disparity gaps and decreasing adverse health outcomes due to T. vaginalis infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Protozoan diseases
KW - Communicable diseases
KW - DISEASES
KW - Trichomonas vaginalis
KW - Vaginitis
KW - Inflammation
KW - Vaginal diseases
KW - Sexually transmitted diseases
KW - Women
KW - United States
N1 - Accession Number: 27299983; Sutton, Madeline 1; Email Address: zxa3@cdc.gov; Sternberg, Maya 1; Koumans, Emilia H. 1; McQuillan, Geraldine 2; Berman, Stuart 1; Markowitz, Lauri 1; Affiliations: 1: National Center for HIV/AIDS, Viral Hepatitis, Sexually Transmitted Disease and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia; 2: National Center for Health Statistics, US Department of Health and Human Services, Hyattsville, Maryland; Issue Info: 11/15/2007, Vol. 45 Issue 10, p1319; Thesaurus Term: Protozoan diseases; Thesaurus Term: Communicable diseases; Thesaurus Term: DISEASES; Subject Term: Trichomonas vaginalis; Subject Term: Vaginitis; Subject Term: Inflammation; Subject Term: Vaginal diseases; Subject Term: Sexually transmitted diseases; Subject Term: Women; Subject: United States; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1086/522532
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, J.
AU - Kim, H.
AU - Jeong, J.C.
AU - Park, E.S.
AU - Hwang, K.W.
AU - Yang, S.J.
AU - Jeong, J.H.
T1 - Determination of beraprost in human plasma by a high-performance liquid chromatography–tandem mass spectrometry
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2007/11/15/
VL - 859
IS - 2
M3 - Article
SP - 229
EP - 233
SN - 15700232
AB - Abstract: A simple, rapid, sensitive and specific liquid chromatography–tandem mass spectrometry method was developed and validated for quantification of beraprost, a stable, orally active prostacyclin analogue with vasodilatory, antiplatelet and cytoprotective effects. The analyte and internal standard, indomethacin, were extracted by solid-phase extraction using OASIS HLB cartridge. The chromatographic separation was performed on a C18 column with a mobile of 0.1% formic acid–methanol (30:70, v/v). The highest daughter ion of deprotonated analyte was quantitated in negative ionization by multiple reactions monitoring with a mass spectrometer. The mass transitions m/z 397>269 and m/z 356>312 were used to measure beraprost and internal standard, respectively. The assay exhibited a linear range from 0.02 to 2ng/mL for beraprost in human plasma. The lower limit of quantitation was 20pg/mL with a relative standard deviation of less than 20%. The method was validated with respect to linearity, sensitivity, specificity, recovery, accuracy and precision. The validated method has been successfully used to analyze human plasma samples for application in pharmacokinetic study. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
KW - FORMIC acid
KW - PROSTACYCLIN
KW - PROSTANOIDS
KW - Beraprost
KW - Pharmacokinetics
KW - Prostacyclin
KW - Tandem mass spectrometry
N1 - Accession Number: 27446453; Lee, J. 1,2 Kim, H. 2 Jeong, J.C. 3 Park, E.S. 4 Hwang, K.W. 5 Yang, S.J. 6 Jeong, J.H. 3; Email Address: jhjeong3@cau.ac.kr; Affiliation: 1: College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea 2: Department of Drug Development Supporting Division, Seoul Pharma Laboratories Co. Ltd. (SPL), Seoul, Republic of Korea 3: Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156-756, Republic of Korea 4: Department of Pathology, College of Medicine, Chung Ang University, Seoul, Republic of Korea 5: Department of Immunology, College of Pharmacy, Chung Ang University, Seoul, Republic of Korea 6: Korea Food and Drug Administration, Seoul, Republic of Korea; Source Info: Nov2007, Vol. 859 Issue 2, p229; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: FORMIC acid; Subject Term: PROSTACYCLIN; Subject Term: PROSTANOIDS; Author-Supplied Keyword: Beraprost; Author-Supplied Keyword: Pharmacokinetics; Author-Supplied Keyword: Prostacyclin; Author-Supplied Keyword: Tandem mass spectrometry; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jchromb.2007.09.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27446453&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Bagnyukova, Tetyana V.
AU - Tryndyak, Volodymyr P.
AU - Muskhelishvili, Levan
AU - Rodriguez-Juarez, Rocio
AU - Kovalchuk, Olga
AU - Han, Tao
AU - Fuscoe, James C.
AU - Ross, Sharon A.
AU - Beland, Frederick A.
T1 - Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/11/15/
VL - 225
IS - 1
M3 - Article
SP - 61
EP - 69
SN - 0041008X
AB - Abstract: Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, which is a life-threatening fatty liver disease with a risk of progression to cirrhosis and hepatocellular carcinoma. In recent years, the high-throughput microarray technology for large-scale analysis of gene expression has become a powerful tool for increasing the understanding of the molecular mechanisms of carcinogenesis and for identifying new biomarkers with diagnostic and predictive values. In the present study, we used the high-throughput microarray technology to determine the gene expression profiles in the liver during early stages of tamoxifen-induced rat hepatocarcinogenesis. Female Fisher 344 rats were fed a 420 ppm tamoxifen containing diet for 12 or 24 weeks, and gene expression profiles were determined in liver of control and tamoxifen-exposed rats. The results indicate that early stages of tamoxifen-induced liver carcinogenesis are characterized by alterations in several major cellular pathways, specifically those involved in the tamoxifen metabolism, lipid metabolism, cell cycle signaling, and apoptosis/cell proliferation control. One of the most prominent changes during early stages of tamoxifen-induced hepatocarcinogenesis is dysregulation of signaling pathways in cell cycle progression from the G1 to S phase, evidenced by the progressive and sustained increase in expression of the Pdgfc, Calb3, Ets1, and Ccnd1 genes accompanied by the elevated level of the PI3K, p-PI3K, Akt1/2, Akt3, and cyclin B, D1, and D3 proteins. The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAMOXIFEN
KW - GENE expression
KW - MOLECULAR pathology
KW - CIRRHOSIS of the liver
KW - Gene expression
KW - Hepatocarcinogenesis
KW - Rat
KW - Tamoxifen
N1 - Accession Number: 27334208; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Bagnyukova, Tetyana V. 1 Tryndyak, Volodymyr P. 1 Muskhelishvili, Levan 2 Rodriguez-Juarez, Rocio 3 Kovalchuk, Olga 3 Han, Tao 4 Fuscoe, James C. 4 Ross, Sharon A. 5 Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Department of Biological Sciences, University of Lethbridge, AB, Canada T1K3M4, USA 4: Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 5: Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA; Source Info: Nov2007, Vol. 225 Issue 1, p61; Subject Term: TAMOXIFEN; Subject Term: GENE expression; Subject Term: MOLECULAR pathology; Subject Term: CIRRHOSIS of the liver; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Hepatocarcinogenesis; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Tamoxifen; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.taap.2007.07.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gamboa da Costa, Gonçalo
AU - Marques, M. Matilde
AU - Fu, Xin
AU - Churchwell, Mona I.
AU - Wang, Yu-Ping
AU - Doerge, Daniel R.
AU - Beland, Frederick A.
T1 - Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and α-hydroxytamoxifen
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2007/11/18/
VL - 257
IS - 2
M3 - Article
SP - 191
EP - 198
SN - 03043835
AB - Abstract: Tamoxifen undergoes sequential metabolism to N-desmethyltamoxifen and N,N-didesmethyltamoxifen. Whereas N-desmethyltamoxifen is a major metabolite in humans, nonhuman primates, and rats, appreciable concentrations of N,N-didesmethyltamoxifen are formed in humans and nonhuman primates but not in rats. This difference in the extent of N,N-didesmethyltamoxifen formation may be important because it has been proposed that N,N-didesmethyltamoxifen inhibits the cytochrome P450 (CYP)-catalyzed α-hydroxylation of tamoxifen and resultant tamoxifen–DNA adduct formation. To test this hypothesis directly, we compared the extent of tamoxifen–DNA adduct formation in rats co-administered 27μmol N,N-didesmethyltamoxifen per kg body weight and either 27μmol tamoxifen per kg body weight or 27μmol α-hydroxytamoxifen per kg body weight daily for 7days. Female Sprague–Dawley rats treated with N,N-didesmethyltamoxifen had a 44% decrease (p >0.05) in CYP 3A2 content (the CYP isoform responsible for tamoxifen α-hydroxylation), an 18% decrease (p =0.010) in CYP 3A activity, and higher blood levels of tamoxifen and N-desmethyltamoxifen compared to rats treated with solvent. Total tamoxifen–DNA adduct levels were 4.1-fold higher (p <0.001) in rats given α-hydroxytamoxifen as compared to tamoxifen. N,N-Didesmethyltamoxifen treatment caused a 1.2-fold increase in total tamoxifen–DNA adduct levels with both tamoxifen and α-hydroxytamoxifen, a difference that was not significant. These results indicate that, with this experimental model, N,N-didesmethyltamoxifen does not impair the metabolism of tamoxifen to a reactive electrophile. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTROGEN antagonists
KW - HIGH performance liquid chromatography
KW - CHROMATOGRAPHIC analysis
KW - DNA
KW - cytochrome P450 ( CYP )
KW - DNA adducts
KW - electrospray mass spectrometry ( ES-MS )
KW - electrospray tandem mass spectrometry ( ES-MS/MS )
KW - high performance liquid chromatography ( HPLC )
KW - N
KW - N,N-Didesmethyltamoxifen
KW - N-Didesmethyltamoxifen
KW - Tamoxifen
N1 - Accession Number: 27052243; Gamboa da Costa, Gonçalo 1,2 Marques, M. Matilde 1 Fu, Xin 2 Churchwell, Mona I. 2 Wang, Yu-Ping 2 Doerge, Daniel R. 2 Beland, Frederick A. 2; Email Address: frederick.beland@fda.hhs.gov; Affiliation: 1: Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal 2: Division of Biochemical Toxicology, HFT-110, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Nov2007, Vol. 257 Issue 2, p191; Subject Term: ESTROGEN antagonists; Subject Term: HIGH performance liquid chromatography; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: DNA; Author-Supplied Keyword: cytochrome P450 ( CYP ); Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: electrospray mass spectrometry ( ES-MS ); Author-Supplied Keyword: electrospray tandem mass spectrometry ( ES-MS/MS ); Author-Supplied Keyword: high performance liquid chromatography ( HPLC ); Author-Supplied Keyword: N; Author-Supplied Keyword: N,N-Didesmethyltamoxifen; Author-Supplied Keyword: N-Didesmethyltamoxifen; Author-Supplied Keyword: Tamoxifen; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.canlet.2007.07.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27052243&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Raval, Angela
AU - Akhavan-Toyserkani, Gita
AU - Brinker, Allen
AU - Avigan, Mark
T1 - Brief Communication: Characteristics of Spontaneous Cases of Tuberculosis Associated with Infliximab.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/11/20/
VL - 147
IS - 10
M3 - Article
SP - 699
EP - W224
SN - 00034819
AB - Background: A warning for tuberculosis was added to the approved labeling for infliximab in October 2001. Objective: To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Design: Case series. Setting: Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. Patients: 130 patients with infliximab-associated tuberculosis. Measurements: Clinical and laboratory data. Results: The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n = 89), history of latent or active tuberculosis (n = 33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n = 25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab. Limitation: Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Conclusion: Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULOSIS
KW - INFLIXIMAB
KW - IMMUNOGLOBULINS
KW - TUMOR necrosis factor
KW - RHEUMATOID arthritis
KW - MYCOBACTERIUM
KW - MEDICAL care
KW - UNITED States
N1 - Accession Number: 27574687; Raval, Angela 1 Akhavan-Toyserkani, Gita 1 Brinker, Allen 1 Avigan, Mark 1; Affiliation: 1: U. S. Food and Drug Administration, Silver Spring, Maryland; Source Info: 11/20/2007, Vol. 147 Issue 10, p699; Subject Term: TUBERCULOSIS; Subject Term: INFLIXIMAB; Subject Term: IMMUNOGLOBULINS; Subject Term: TUMOR necrosis factor; Subject Term: RHEUMATOID arthritis; Subject Term: MYCOBACTERIUM; Subject Term: MEDICAL care; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105939780
T1 - Brief communication: characteristics of spontaneous cases of tuberculosis associated with infliximab.
AU - Raval A
AU - Akhavan-Toyserkani G
AU - Brinker A
AU - Avigan M
Y1 - 2007/11/20/
N1 - Accession Number: 105939780. Language: English. Entry Date: 20080125. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Adverse Drug Event
KW - Infliximab -- Adverse Effects
KW - Tuberculosis -- Chemically Induced
KW - Adult
KW - Aged
KW - Female
KW - Male
KW - Middle Age
KW - Tuberculosis -- Diagnosis
KW - Tuberculosis -- Etiology
SP - 699
EP - 702
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 10
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - Background: A warning for tuberculosis was added to the approved labeling for infliximab in October 2001. Objective: To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Design: Case series. Setting: Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. Patients: 130 patients with infliximab-associated tuberculosis. Measurements: Clinical and laboratory data. Results: The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n = 89), history of latent or active tuberculosis (n = 33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n = 25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab. Limitation: Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Conclusion: Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab.
SN - 0003-4819
AD - US Food and Drug Administration, Silver Spring, MD
U2 - PMID: 18025446.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Jay
AU - Welcome, Daniel E.
AU - Dong, Ren G.
AU - Joon Song, Won
AU - Hayden, Charles
T1 - Time–frequency characterization of hand-transmitted, impulsive vibrations using analytic wavelet transform
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2007/11/20/
VL - 308
IS - 1/2
M3 - Article
SP - 98
EP - 111
SN - 0022460X
AB - Current guidelines to assess health risk of hand–arm vibration are based on the frequency-weighted rms acceleration level, therefore do not fully consider the effect of temporal variations of the spectral energy. Time averaging effect involved with the frequency analysis may severely underestimate the risk of impact tools. A time–frequency (T–F) analysis is necessary to characterize a highly transient signal whose spectral characteristics change rapidly in time. The analytic wavelet transform (AWT) is an ideal T–F analysis tool as it possesses the advantages of both the Fourier and wavelet transforms. The AWT is applied to acceleration signals measured from six tools, five impact type tools and one relatively steady-type tool, to explore possible improvements of the current risk assessment method of hand–arm vibration exposure. Based on the unique capability of the AWT, several new concepts including frequency-weighted time history, cumulative injury function, and cumulative injury index are defined in this study. Possible applications of these new concepts to hand–arm vibration research are described. Based on the results from this study, needs for future research are discussed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRATION (Mechanics) -- Physiological effect
KW - WAVELETS (Mathematics)
KW - FOURIER transforms
KW - RISK assessment
KW - HAND -- Wounds & injuries
KW - ARM -- Wounds & injuries
N1 - Accession Number: 26709482; Kim, Jay 1; Email Address: jay.kim@uc.edu Welcome, Daniel E. 2 Dong, Ren G. 2 Joon Song, Won 1 Hayden, Charles 3; Affiliation: 1: Mechanical, Industrial and Nuclear Engineering Department, University of Cincinnati, Cincinnati, OH 45221-0072, USA 2: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA 3: National Institute for Occupational Safety and Health, Engineering & Physical Hazards Branch, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Nov2007, Vol. 308 Issue 1/2, p98; Subject Term: VIBRATION (Mechanics) -- Physiological effect; Subject Term: WAVELETS (Mathematics); Subject Term: FOURIER transforms; Subject Term: RISK assessment; Subject Term: HAND -- Wounds & injuries; Subject Term: ARM -- Wounds & injuries; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jsv.2007.07.046
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ashar, Binita S.
AU - Ferriter, Ann
T1 - Radiofrequency Identification Technology in Health Care.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2007/11/21/
VL - 298
IS - 19
M3 - Article
SP - 2305
EP - 2307
SN - 00987484
AB - This article presents information of radio frequency identification (RFID) and how it can be a wonderful tool to improve patient care. But, because there are so many wireless technologies at work in medical settings, there is the possibility of interference between systems. The authors explain RFID and its many advantages. Two general categories for using RFID technology are being established in health care settings: for the control of drugs and medical devices and the other to capture data from the point of care. The potential risks for communication interference are listed along with ideas on how to prevent it.
KW - RADIO frequency identification systems
KW - EVALUATION
KW - WIRELESS communication systems
KW - MEDICAL care
KW - HOSPITALS -- Drug distribution systems
KW - HOSPITALS -- Electric equipment
KW - ELECTRIC interference
KW - MEDICAL equipment
KW - ELECTROMAGNETIC interference
KW - RADIO interference
N1 - Accession Number: 27603231; Ashar, Binita S. 1; Email Address: binita.ashar@fda.hhs.gov Ferriter, Ann 1; Affiliation: 1: Office of Device Evaluation, Center for Devices and Radiological Health, US Food and Drug Administration,Rockville, Maryland; Source Info: 11/21/2007, Vol. 298 Issue 19, p2305; Subject Term: RADIO frequency identification systems; Subject Term: EVALUATION; Subject Term: WIRELESS communication systems; Subject Term: MEDICAL care; Subject Term: HOSPITALS -- Drug distribution systems; Subject Term: HOSPITALS -- Electric equipment; Subject Term: ELECTRIC interference; Subject Term: MEDICAL equipment; Subject Term: ELECTROMAGNETIC interference; Subject Term: RADIO interference; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 334220 Radio and Television Broadcasting and Wireless Communications Equipment Manufacturing; NAICS/Industry Codes: 517210 Wireless Telecommunications Carriers (except Satellite); NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106003883
T1 - Radiofrequency identification technology in health care: benefits and potential risks.
AU - Ashar BS
AU - Ferriter A
AU - Ashar, Binita S
AU - Ferriter, Ann
Y1 - 2007/11/21/
N1 - Accession Number: 106003883. Language: English. Entry Date: 20080229. Revision Date: 20161112. Publication Type: journal article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Electromagnetics
KW - Electronics
KW - Equipment and Supplies
KW - Radio Waves
KW - Health Care Industry
KW - Relative Risk
KW - Human
SP - 2305
EP - 2307
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 298
IS - 19
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of Device Evaluation, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland 20850, USA
AD - Office of Device Evaluation, Center for Devices and Radiological Health, US Food and Drug Administration, 9200 Corporate Blvd, Rockville, MD 20850; binta.ashar@fda.hhs.gov
U2 - PMID: 18029835.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Forbeck, Erin M.
AU - Evans, Cory D.
AU - Gilleran, John A.
AU - Pixu Li
AU - Joullié, Madeleine M.
T1 - A Regio- and Stereoselective Approach to Quaternary Centers from Chiral Trisubstituted Aziridines.
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
Y1 - 2007/11/21/
VL - 129
IS - 46
M3 - Article
SP - 14463
EP - 14469
SN - 00027863
AB - A thorough investigation of a regio- and stereospecific aziridine ring opening reaction presents new synthetic technology for the construction of a variety of quaternary β-substituted-α-amino functional groups. Mild, metal-free reaction conditions allow for application in highly functionalized systems. This reaction has been applied to the challenging stereoselective formation of tertiary alkyl-aryl ethers. The strategy for the formation of these hindered ethers has been investigated using a variety of functionalized aziridines and phenols to determine the scope of the reaction. Other nucleophiles, such as thiolate, azide, and chloride, have also been examined to encompass the synthesis of a broader range of functionalities. This aziridine ring opening reaction manifold has demonstrated utility in assembling: β-substituted-a-amino carboxamides, β-substituted-a-amino esters, β-substituted-α-amino silyl ethers, β-thio-a-amino carboxamides, β-azido-α-amino carboxamides, and β-halo-α-amino carboxamides. Studies to probe the effect of the aziridine substitution patterns show that alkyl aziridines display similar reactivity to alkynyl aziridines, giving insight into mechanistic possibilities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Chemical Society is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANIC compounds
KW - ETHERS
KW - PHENOLS
KW - ORGANIC chemistry
KW - ALCOHOLS (Chemical class)
KW - AROMATIC compounds
KW - PHENOL
KW - ESTERS
N1 - Accession Number: 27725164; Forbeck, Erin M. 1 Evans, Cory D. 2 Gilleran, John A. 1 Pixu Li 3 Joullié, Madeleine M. 1; Email Address: mjoullie@sasupenn.edu; Affiliation: 1: Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 2: Food and Drug Administration-CVM, MPN2 RME 324 HFV-l42, 7500 Standish Place, Rockville, MD 20855 3: Wyeth Research, 401 N. Middletown Rd., Pearl River, NY, 10965; Source Info: 11/21/2007, Vol. 129 Issue 46, p14463; Subject Term: ORGANIC compounds; Subject Term: ETHERS; Subject Term: PHENOLS; Subject Term: ORGANIC chemistry; Subject Term: ALCOHOLS (Chemical class); Subject Term: AROMATIC compounds; Subject Term: PHENOL; Subject Term: ESTERS; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C. Özgen
T1 - Swelling-induced volumetric strains internal to a stressed coal associated with CO2 sorption
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2007/11/22/
VL - 72
IS - 3/4
M3 - Article
SP - 209
EP - 220
SN - 01665162
AB - Abstract: It is generally accepted that typical coalbed gases (methane and carbon dioxide) are sorbed (both adsorbed and absorbed) in the coal matrix causing it to swell and resulting in local stress and strain variations in a coalbed confined under overburden pressure. The swelling, interactions of gases within the coal matrix and the resultant changes in the permeability, sorption, gas flow mechanics in the reservoir, and stress state of the coal can impact a number of reservoir-related factors. These include effective production of coalbed methane, degasification of future mining areas by drilling horizontal and vertical degasification wells, injection of CO2 as an enhanced coalbed methane recovery technique, and concurrent CO2 sequestration. Such information can also provide an understanding of the mechanisms behind gas outbursts in underground coal mines. The spatio-temporal volumetric strains in a consolidated Pittsburgh seam coal sample were evaluated while both confining pressure and carbon dioxide (CO2) pore pressure were increased to keep a constant positive effective stress on the sample. The changes internal to the sample were evaluated by maps of density and atomic number determined by dual-energy X-ray computed tomography (X-ray CT). Early-time images, as soon as CO2 was introduced, were also used to calculate the macroporosity in the coal sample. Scanning electron microscopy (SEM) and photographic images of the polished section of the coal sample at X-ray CT image location were used to identify the microlithotypes and microstructures. The CO2 sorption-associated swelling and volumetric strains in consolidated coal under constant effective stress are heterogeneous processes depending on the lithotypes present. In the time scale of the experiment, vitrite showed the highest degree of swelling due to dissolution of CO2, while the clay (kaolinite) and inertite region was compressed in response. The volumetric strains associated with swelling and compression were between ±15% depending on the location. Although the effective stress on the sample was constant, it varied within the sample as a result of the internal stresses created by gas sorption-related structural changes. SEM images and porosity calculations revealed that the kaolinite and inertite bearing layer was highly porous, which enabled the fastest CO2 uptake and the highest degree of compression. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL
KW - ABSORPTION
KW - SCANNING electron microscopy
KW - X-ray spectroscopy
KW - Carbon dioxide
KW - Coal
KW - Gas outbursts
KW - Sequestration
KW - Sorption
KW - Swelling
KW - Volumetric strain
KW - X-ray computed tomography
N1 - Accession Number: 27353225; Karacan, C. Özgen 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, United States; Source Info: Nov2007, Vol. 72 Issue 3/4, p209; Subject Term: COAL; Subject Term: ABSORPTION; Subject Term: SCANNING electron microscopy; Subject Term: X-ray spectroscopy; Author-Supplied Keyword: Carbon dioxide; Author-Supplied Keyword: Coal; Author-Supplied Keyword: Gas outbursts; Author-Supplied Keyword: Sequestration; Author-Supplied Keyword: Sorption; Author-Supplied Keyword: Swelling; Author-Supplied Keyword: Volumetric strain; Author-Supplied Keyword: X-ray computed tomography; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 454310 Fuel Dealers; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.coal.2007.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C. Özgen
T1 - Development and application of reservoir models and artificial neural networks for optimizing ventilation air requirements in development mining of coal seams
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2007/11/22/
VL - 72
IS - 3/4
M3 - Article
SP - 221
EP - 239
SN - 01665162
AB - Abstract: In longwall development mining of coal seams, planning, optimizing and providing adequate ventilation are very important steps to eliminate the accumulation of explosive methane–air mixtures in the working environment. Mine operators usually try to supply maximum ventilation air based on the capacity of the system and the predicted need underground. This approach is neither economical nor safer as ventilation capacity may decrease in time depending on various mining and coalbed parameters. Thus, it is important to develop better engineered approaches to optimize mine ventilation effectiveness and, therefore, to ensure a safer work environment. This study presents an approach using coalbed methane reservoir modeling and an artificial neural network (ANN) design for prediction and optimization of methane inflows and ventilation air requirements to maintain methane concentrations below statutory limits. A coalbed reservoir model of a three-entry development section, which is typical of Pittsburgh Coalbed mines in the Southwestern Pennsylvania section of Northern Appalachian Basin, was developed taking into account the presence and absence of shielding boreholes around the entries against methane inflow. In the model, grids were dynamically controlled to simulate the advance of mining for parametric simulations. Development and application of artificial neural networks as an optimization tool for ventilation requirements are introduced. Model predictions are used to develop, train, and test artificial neural networks to optimize ventilation requirements. The sensitivity and applications of proposed networks for predicting simulator data are presented and discussed. Results show that reservoir simulations and integrated ANN models can be practical and powerful tools for predicting methane emissions and optimization of ventilation air requirements. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - VENTILATION
KW - METHANE
KW - AIR conditioning
KW - Artificial neural networks
KW - Coalbed reservoir modeling
KW - Mine safety
KW - Mine ventilation
KW - Reservoir simulation
KW - Underground mining
N1 - Accession Number: 27353226; Karacan, C. Özgen 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH) Pittsburgh Research Laboratory Pittsburgh, PA 15236, United States; Source Info: Nov2007, Vol. 72 Issue 3/4, p221; Subject Term: COAL mines & mining; Subject Term: VENTILATION; Subject Term: METHANE; Subject Term: AIR conditioning; Author-Supplied Keyword: Artificial neural networks; Author-Supplied Keyword: Coalbed reservoir modeling; Author-Supplied Keyword: Mine safety; Author-Supplied Keyword: Mine ventilation; Author-Supplied Keyword: Reservoir simulation; Author-Supplied Keyword: Underground mining; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.coal.2007.02.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shaikh, Badar
AU - Rummel, Nathan
AU - Gieseker, Charles
AU - Chu, Pak-Sin
AU - Reimschuessel, Renate
T1 - Residue depletion of tritium-labeled ivermectin in rainbow trout following oral administration
JO - Aquaculture
JF - Aquaculture
Y1 - 2007/11/26/
VL - 272
IS - 1-4
M3 - Article
SP - 192
EP - 198
SN - 00448486
AB - Abstract: The residue depletion and metabolism of tritium-labeled ivermectin were studied in the muscle tissue of rainbow trout following oral treatment. Fish were administered 3H-ivermectin at the dose level of 0.1 mg/kg of body weight (9.25 μCi) in a gel-capsule via stomach tube. At each of the following withdrawal times 6 fish were sedated with MS-222, euthanatized, bled, scaled and fillets with adhering skin and bile collected: 1, 3, 7, 14, 28, 35 and 42 days. The muscle tissues were homogenized in dry ice and analyzed for total radioactive residues (TRR) by sample oxidation. The homogenized tissue was further extracted with acetonitrile for residue characterization by high pressure liquid chromatography (LC). Maximum TRR of 71 ng/g and 3857 ng/mL (ivermectin equivalent concentration) were detected in muscle and bile, respectively, by sample oxidation on post-dose day 3. LC analysis of the muscle extract revealed that the maximum TRR of 55 ng/g (representing ivermectin and metabolites) was also detected on post-dose day 3. By post-dose day 35, about 65% of the TRR in the muscle tissue was an unknown metabolite. Preliminary mass spectrometry results indicated that the unknown metabolite may be 3″-O-demethyl-ivermectin B1a. This metabolite could serve as a potential marker residue for ivermectin in rainbow trout, in contrast to cattle, swine and sheep where the parent ivermectin is known to be the marker residue. [Copyright &y& Elsevier]
AB - Copyright of Aquaculture is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AQUACULTURE
KW - METABOLISM
KW - IVERMECTIN
KW - RAINBOW trout
KW - Aquaculture
KW - Ivermectin
KW - Metabolism
KW - Rainbow trout
N1 - Accession Number: 27445011; Shaikh, Badar; Email Address: badaruddin.shaikh@fda.hhs.gov Rummel, Nathan 1 Gieseker, Charles 1 Chu, Pak-Sin 1 Reimschuessel, Renate 1; Affiliation: 1: Food & Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel Maryland 20708, United States; Source Info: Nov2007, Vol. 272 Issue 1-4, p192; Subject Term: AQUACULTURE; Subject Term: METABOLISM; Subject Term: IVERMECTIN; Subject Term: RAINBOW trout; Author-Supplied Keyword: Aquaculture; Author-Supplied Keyword: Ivermectin; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Rainbow trout; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.aquaculture.2007.08.050
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Tengchuan Jin
AU - Tong-Jen Fu
AU - Kothary, Mahendra H.
AU - Howard, Andrew
AU - Yu-Zhu Zhang
T1 - Crystallization and initial crystallographic characterization of a vicilin-type seed storage protein from Pinus koraiensis.
JO - Acta Crystallographica: Section F (Wiley-Blackwell)
JF - Acta Crystallographica: Section F (Wiley-Blackwell)
Y1 - 2007/12//
VL - 63
IS - 12
M3 - Other
SP - 1041
EP - 1043
SN - 17443091
AB - The cupin superfamily of proteins includes the 7S and 11S seed storage proteins. Many members of this family of proteins are known allergens. In this study, the Korean pine ( Pinus koraiensis) vicilin-type 7S seed storage protein was isolated from defatted pine-nut extract and purified by sequential gel-filtration and anion-exchange chromatography. Well diffracting single crystals were obtained by the vapor-diffusion method in hanging drops. The crystals belong to the primitive cubic space group P213, with unit-cell parameters a = b = c = 148.174 Å. Two vicilin molecules were present in the asymmetric unit and the Matthews coefficient was determined to be 2.90 Å3 Da−1, with a corresponding solvent content of ∼58%. A molecular-replacement structural solution has been obtained using the program Phaser. Refinement of the structure is currently under way. [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Crystallographica: Section F (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYSTALLIZATION
KW - PINUS koraiensis
KW - ALLERGENS
KW - PINE
KW - CRYSTALLOGRAPHY
KW - allergens
KW - pine nuts
KW - seed storage protein.
N1 - Accession Number: 27767048; Tengchuan Jin 1 Tong-Jen Fu 2 Kothary, Mahendra H. 3 Howard, Andrew 1 Yu-Zhu Zhang 1; Email Address: zhangy@iit.edu; Affiliation: 1: Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA 2: National Center for Food Safety and Technology, US Food and Drug Administration, Summit-Argo, IL 60501, USA 3: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA; Source Info: Dec2007, Vol. 63 Issue 12, p1041; Subject Term: CRYSTALLIZATION; Subject Term: PINUS koraiensis; Subject Term: ALLERGENS; Subject Term: PINE; Subject Term: CRYSTALLOGRAPHY; Author-Supplied Keyword: allergens; Author-Supplied Keyword: pine nuts; Author-Supplied Keyword: seed storage protein.; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 3p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Chart; Document Type: Other
L3 - 10.1107/S1744309107054310
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27767048&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lal, Renu
AU - Kremzner, Mary
T1 - Introduction to the new prescription drug labeling by the Food and Drug Administration.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2007/12//12/1/2007
VL - 64
IS - 23
M3 - Article
SP - 2488
EP - 2494
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The revised prescription drug labeling developed by the Food and Drug Administration (FDA) is described. Summary. A new FDA final rule, ‘Requirements on Content and Format of Labeling for Human Prescription Drug and Biological Products,’ became effective in June 2006. The rule is part of FDA's initiative to manage the risks of medical product use and minimize adverse events. The new labeling reorders and reorganizes sections found in the previous labeling format. A label is now divided into highlights of prescribing information, contents of the full prescribing information (FPI), and the FPI. The highlights section is a half-page summary of the information that health care practitioners most commonly refer to and view as most important. This section contains crossreferences to details in the FPI section. The contents section serves as a navigational tool that references all the sections in the FPI. The FPI section has been revised as to content, format, and order to make information clearer and more usable. FDA has instituted a flexible implementation schedule that phases in the new labeling requirements; more time to achieve compliance is provided for older products. The revision of labeling for products approved or submitted for approval under an abbreviated new drug application (ANDA) depends on the labeling of the listed drug referenced in the ANDA. The new requirements do not apply to nonprescription drug products. Conclusion. FDA has designed new labeling to help health care practitioners easily find, read, and convey information important for the safe and effective use of prescription drugs. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LABELS
KW - PRODUCT management
KW - CONSUMER protection
KW - UNITED States
KW - Biologicals
KW - Compliance
KW - Drugs
KW - Food and Drug Administration (U.S.)
KW - Industry
KW - investigational
KW - Labeling
KW - pharmaceutical
KW - Prescriptions
KW - Regulations
KW - Toxicity
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 27961472; Lal, Renu 1 Kremzner, Mary 2; Affiliation: 1: Team Leader, Division of Drug Information, Office of Training and Communications, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), Rockville, MD 2: Deputy Director, Division of Drug Information, Office of Training and Communications, Center for Drug Evaluation and Research, FDA; Source Info: 12/1/2007, Vol. 64 Issue 23, p2488; Subject Term: LABELS; Subject Term: PRODUCT management; Subject Term: CONSUMER protection; Subject Term: UNITED States; Author-Supplied Keyword: Biologicals; Author-Supplied Keyword: Compliance; Author-Supplied Keyword: Drugs; Author-Supplied Keyword: Food and Drug Administration (U.S.); Author-Supplied Keyword: Industry; Author-Supplied Keyword: investigational; Author-Supplied Keyword: Labeling; Author-Supplied Keyword: pharmaceutical; Author-Supplied Keyword: Prescriptions; Author-Supplied Keyword: Regulations; Author-Supplied Keyword: Toxicity; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.2146/ajhp070130
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27961472&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 106011385
T1 - Introduction to the new prescription drug labeling by the Food and Drug Administration.
AU - Lal R
AU - Kremzner M
Y1 - 2007/12//12/1/2007
N1 - Accession Number: 106011385. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Drug Labeling -- Legislation and Jurisprudence
KW - Medication Errors -- Prevention and Control
KW - Biological Products -- Standards
KW - Drug Approval -- Legislation and Jurisprudence
KW - Drug Labeling -- Standards
KW - Drugs, Investigational -- Standards
KW - Drugs, Investigational -- Therapeutic Use
KW - Legislation, Drug
KW - Prescriptions, Drug -- Standards
KW - United States Food and Drug Administration
KW - United States
SP - 2488
EP - 2494
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 64
IS - 23
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - PURPOSE: The revised prescription drug labeling developed by the Food and Drug Administration (FDA) is described. SUMMARY: A new FDA final rule, 'Requirements on Content and Format of Labeling for Human Prescription Drug and Biological Products,' became effective in June 2006. The rule is part of FDA's initiative to manage the risks of medical product use and minimize adverse events. The new labeling reorders and reorganizes sections found in the previous labeling format. A label is now divided into highlights of prescribing information, contents of the full prescribing information (FPI), and the FPI. The highlights section is a half-page summary of the information that health care practitioners most commonly refer to and view as most important. This section contains cross-references to details in the FPI section. The contents section serves as a navigational tool that references all the sections in the FPI. The FPI section has been revised as to content, format, and order to make information clearer and more usable. FDA has instituted a flexible implementation schedule that phases in the new labeling requirements; more time to achieve compliance is provided for older products. The revision of labeling for products approved or submitted for approval under an abbreviated new drug application (ANDA) depends on the labeling of the listed drug referenced in the ANDA. The new requirements do not apply to nonprescription drug products. CONCLUSION: FDA has designed new labeling to help health care practitioners easily find, read, and convey information important for the safe and effective use of prescription drugs.
SN - 1079-2082
AD - Team Leader, Division of Drug Information, Office of Training and Communications, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD
U2 - PMID: 18029957.
DO - 10.2146/ajhp070130
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=106011385&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105882209
T1 - Characteristics of patients receiving hospice care at home versus in nursing homes: results from the National Home and Hospice Care survey and the National Nursing Home survey.
AU - Han B
AU - Tiggle RB
AU - Remsburg RE
Y1 - 2007/12//Dec2007/Jan2008
N1 - Accession Number: 105882209. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Dec2007/Jan2008. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Gerontologic Care; Palliative Care/Hospice. NLM UID: 9008229.
KW - Home Health Care
KW - Hospice Patients
KW - Nursing Home Patients
KW - Activities of Daily Living
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Dementia
KW - Descriptive Statistics
KW - Diagnosis
KW - Health Resource Utilization
KW - Health Services Needs and Demand
KW - Hospice Care
KW - Medicaid
KW - Middle Age
KW - Multivariate Analysis
KW - Nursing Homes
KW - Post Hoc Analysis
KW - Record Review
KW - Retrospective Design
KW - Sampling Methods
KW - Secondary Analysis
KW - Surveys
KW - T-Tests
KW - Human
SP - 479
EP - 486
JO - American Journal of Hospice & Palliative Medicine
JF - American Journal of Hospice & Palliative Medicine
JA - AM J HOSP PALLIAT MED
VL - 24
IS - 6
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1049-9091
AD - US Department of Health and Human Services, 1 Choke Cherry Road, Room 7-1010, Rockville, MD 20782; beth.han@samhsa.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lucas, Devin L.
AU - Lincoln, Jennifer M.
T1 - Fatal Falls Overboard on Commercial Fishing Vessels in Alaska.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/12//
VL - 50
IS - 12
M3 - Article
SP - 962
EP - 968
SN - 02713586
AB - The article presents a case study which focused on the implication of fatal falls to commercial fishing fatalities in Alaska. It used the data from the Occupational Injury Surveillance System from 1990-2005 where an in-depth analysis of these fatalities were done to identify areas for intervention. It reported about 71 fatal falls overboard during the 16 year time frame which are mostly common on working with fishing gear, losing balance and heavy weather. Many fatal falls overboard may be prevented by targeting its interventions which include the creation of more enclosed work spaces, managing lines and wearing of personal flotation devices.
KW - Fisheries
KW - Weather
KW - Falls (Accidents)
KW - Fisheries -- Equipment & supplies
KW - Equilibrium (Physiology)
KW - Life jackets (Garments)
KW - Strategic planning
KW - Case studies
KW - Alaska
KW - drowning
KW - fall
KW - fishing
KW - overboard
N1 - Accession Number: 27771493; Lucas, Devin L. 1; Email Address: dlucas@cdc.gov; Lincoln, Jennifer M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Alaska Field Station, Anchorage, Alaska; Issue Info: Dec2007, Vol. 50 Issue 12, p962; Thesaurus Term: Fisheries; Thesaurus Term: Weather; Subject Term: Falls (Accidents); Subject Term: Fisheries -- Equipment & supplies; Subject Term: Equilibrium (Physiology); Subject Term: Life jackets (Garments); Subject Term: Strategic planning; Subject Term: Case studies; Subject: Alaska; Author-Supplied Keyword: drowning; Author-Supplied Keyword: fall; Author-Supplied Keyword: fishing; Author-Supplied Keyword: overboard; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; Number of Pages: 7p; Illustrations: 4 Charts, 1 Graph, 1 Map; Document Type: Article
L3 - 10.1002/ajim.20509
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27771493&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoppin, Jane A.
AU - Valcin, Martin
AU - Henneberger, Paul K.
AU - Kullman, Greg J.
AU - Umbach, David M.
AU - London, Stephanie J.
AU - Alavanja, Michael C.R.
AU - Sandier, Dale P.
T1 - Pesticide Use and Chronic Bronchitis Among Farmers in the Agricultural Health Study.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2007/12//
VL - 50
IS - 12
M3 - Article
SP - 969
EP - 979
SN - 02713586
AB - The article presents a case study which focused on the incidence of pesticide use and chronic bronchitis among farmers in the U.S. Pesticides were evaluated for they are considered as risk factors for chronic bronchitis where about 654 farmers reported to have the disease after age 19. 11 types of pesticides were linked with the disease including Heptachlor which had the highest odds ratio (OR). Increased prevalence for chronic bronchitis was seen in those who had a history of high pesticide exposure such as those who applied pesticides in off-farm jobs. It concluded that frequent use of pesticides can increase the prevalence of chronic bronchitis.
KW - Pesticides
KW - Farmers
KW - Toxicology
KW - Heptachlor
KW - Agricultural chemicals
KW - Bronchitis
KW - Medical records
KW - Case studies
KW - United States
KW - agricultural exposures
KW - occupational exposure
KW - pesticides
KW - respiratory disease
N1 - Accession Number: 27771494; Hoppin, Jane A. 1,2; Email Address: hoppin1@niehs.nih.gov; Valcin, Martin 1,3; Henneberger, Paul K. 3; Kullman, Greg J. 3; Umbach, David M. 4; London, Stephanie J. 1; Alavanja, Michael C.R. 5; Sandier, Dale P. 1; Affiliations: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina; 2: NIEHS, Epidemiology Branch, MO A3-05, P.O. Box 12233, Research Triangle Park, NC 27709-2233; 3: Field Studies Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 4: Biostatistics Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina; 5: Occupational Epidemiology Branch, National Cancer Institute, NIH, DHHS, Rockville, Maryland; Issue Info: Dec2007, Vol. 50 Issue 12, p969; Thesaurus Term: Pesticides; Thesaurus Term: Farmers; Thesaurus Term: Toxicology; Thesaurus Term: Heptachlor; Thesaurus Term: Agricultural chemicals; Subject Term: Bronchitis; Subject Term: Medical records; Subject Term: Case studies; Subject: United States; Author-Supplied Keyword: agricultural exposures; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: respiratory disease; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; Number of Pages: 11p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1002/ajim.20523
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105970528
T1 - Spreading the word, not the infection: reaching hospitalists about the prevention of antimicrobial resistance.
AU - Bush-Knapp ME
AU - Brinsley-Rainisch KJ
AU - Lawton-Ciccarone RM
AU - Sinkowitz-Cochran RL
AU - Dressler DD
AU - Budnitz T
AU - Williams MV
Y1 - 2007/12//
N1 - Accession Number: 105970528. Language: English. Entry Date: 20080215. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 8004854.
KW - Antibiotics -- Adverse Effects
KW - Drug Resistance, Microbial
KW - Hospitalists -- Education
KW - Quality Improvement -- Education
KW - Unnecessary Procedures
KW - Audiorecording
KW - Centers for Disease Control and Prevention (U.S.)
KW - Conceptual Framework
KW - Convenience Sample
KW - Cross Infection -- Prevention and Control
KW - Descriptive Statistics
KW - Georgia
KW - Interviews
KW - Physician Attitudes
KW - Professional Compliance
KW - Seminars and Workshops
KW - Telephone
KW - Human
SP - 656
EP - 661
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 35
IS - 10
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: To reach and engage hospitalists in the prevention of antimicrobial resistance, the Society of Hospital Medicine and the Centers for Disease Control and Prevention developed and conducted a quality improvement workshop based on the Centers for Disease Control and Prevention's Campaign to Prevent Antimicrobial Resistance in Healthcare Settings. METHODS: We aimed to examine motivating factors, perceived barriers, and cues to action for hospitalists to learn about and engage in the prevention of antimicrobial resistance and to determine whether a workshop can facilitate the implementation of a quality improvement project. Using the Health Belief Model as a theoretical framework, we interviewed hospitalists who attended (attendees) and did not attend (nonattendees) the workshop. Data were qualitatively coded and analyzed. RESULTS: Nine attendees and 10 nonattendees participated in interviews. Motivating factors for attending the workshop included an interest in the topic of quality improvement and antimicrobial resistance prevention, the promotion of the workshop by institutions and colleagues, the opportunity to network with colleagues, and the qualifications of the presenter. Barriers to involvement in quality improvement efforts and the prevention of antimicrobial resistance for both attendees and nonattendees included perceived lack of time, other institutional priorities, and lack of administrative and institutional support. Attendees and nonattendees also identified perceived effective and preferred methods for receiving information about antimicrobial resistance, such as workshops and presentations, e-mail, institutional involvement, and the Internet. Overall, attendees thought that the workshop could be effective in facilitating the implementation of a quality improvement project. CONCLUSION: By considering factors that influence behavioral change, interventions, such as the Society of Hospital Medicine workshop, have the ability to reach and engage clinicians such as hospitalists in quality improvement efforts to prevent antimicrobial resistance and improve adherence to infection control strategies. Furthermore, this study demonstrated that the Health Belief Model can provide an applicable framework for examining factors that influence clinician behavior.
SN - 0196-6553
AD - Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services
U2 - PMID: 18063130.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105970528&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Fishman, J. A.
AU - Greenwald, M. A.
AU - Kuehnert, M. J.
T1 - Enhancing Transplant Safety: A New Era in the Microbiologic Evaluation of Organ Donors?
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2007/12//
VL - 7
IS - 12
M3 - Editorial
SP - 2652
EP - 2654
PB - Wiley-Blackwell
SN - 16006135
AB - The article focuses on the enhancement of transplant safety and the microbiologic evaluation of organ donors. According to the author, a number of factors have contributed to the increased recognition of the potential for disease transmission with organ transplantation. Any additional tests proposed for donor screening must be considered in terms of the potential problems raised by limitations in testing technology and possible benefits.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - COMMUNICABLE diseases -- Transmission
KW - MEDICAL screening
KW - HEALTH risk assessment
N1 - Accession Number: 27258023; Fishman, J. A. 1; Email Address: jfishman@partners.org Greenwald, M. A. 2 Kuehnert, M. J. 3; Affiliation: 1: Transplant Infectious Disease Program and MGH Transplant Center, Massachusetts General Hospital, Boston, MA 2: CDR, US Public Health Service, Division of Human Tissues, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 3: CDR, US Public Health Service, Office of Blood, Organ and Other Tissue Safety (proposed), Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, GA; Source Info: Dec2007, Vol. 7 Issue 12, p2652; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1111/j.1600-6143.2007.02023.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27258023&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimmerman, A. M.
AU - Depaola, A.
AU - Bowers, J. C.
AU - Krantz, J. A.
AU - Nordstrom, J. L.
AU - Johnson, C. N.
AU - Grimesl, D. J.
T1 - Variability of Total and Pathogenic Vibrio parahaemolyticus Densities in Northern Gulf of Mexico Water and Oysters.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/12//
VL - 73
IS - 23
M3 - Article
SP - 7589
EP - 7596
SN - 00992240
AB - Vibrio parahaemolyticus is indigenous to coastal environments and a frequent cause of seafood-borne gastroenteritis in the United States, primarily due to raw-oyster consumption. Previous seasonal-cycle studies of V. parahaemolyticus have identified water temperature as the strongest environmental predictor. Salinity has also been identified, although it is evident that its effect on annual variation is not as pronounced. The effects of other environmental factors, both with respect to the seasonal cycle and intraseasonal variation, are uncertain. This study investigated intraseasonal variations of densities of total and pathogenic V. parahaemolyticus organisms in oysters and overlying waters during the summer of 2004 at two sites in the northern Gulf of Mexico. Regression analyses indicated significant associations (P < 0.001) between total V. parahaemolyticus densities and salinity, as well as turbidity in water and in oysters at the Mississippi site but not at the Alabama site. Pathogenic V. parahaemolyticus organisms in Mississippi oyster and water samples were detected in 56% (9 out of 16) and 78% (43 out of 55) of samples, respectively. In contrast, 44% (7 out of 16) of oyster samples and 30% (14 out of 47) of water samples from Alabama were positive. At both sites, there was greater sample-to-sample variability in pathogenic V. parahaemolyticus densities than in total V. parahaemolyticus densities. These data suggest that, although total V. parahaemolyticus densities may be very informative, there is greater uncertainty when total V. parahaemolyticus densities are used to predict the risk of infection by pathogenic V. parahaemolyticus than previously recognized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO parahaemolyticus
KW - FOODBORNE diseases
KW - FOOD
KW - PATHOGENIC microorganisms
KW - OYSTERS
KW - SEAFOOD
KW - FOOD pathogens
KW - SALINITY
KW - MEXICO, Gulf of
N1 - Accession Number: 27973732; Zimmerman, A. M. 1 Depaola, A. 2 Bowers, J. C. 3 Krantz, J. A. 2 Nordstrom, J. L. 2 Johnson, C. N. 1 Grimesl, D. J. 1; Email Address: jay.grirnes@usm.edu; Affiliation: 1: University of Southern Mississippi, Gulf Coast Research Laboratory, Ocean Springs, Mississippi 2: Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 3: Food and Drug Administration, College Park, Maryland; Source Info: Dec2007, Vol. 73 Issue 23, p7589; Subject Term: VIBRIO parahaemolyticus; Subject Term: FOODBORNE diseases; Subject Term: FOOD; Subject Term: PATHOGENIC microorganisms; Subject Term: OYSTERS; Subject Term: SEAFOOD; Subject Term: FOOD pathogens; Subject Term: SALINITY; Subject Term: MEXICO, Gulf of; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 445220 Fish and Seafood Markets; Number of Pages: 8p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1128/AEM.01700-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27973732&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haiyan Xu
AU - Heinze, Thomas M.
AU - Siwei Chen
AU - Cerniglia, Carl E.
AU - Huizhong Chen
T1 - Anaerobic Metabolism of 1-Amino-2-Naphthol-Based Azo Dyes (Sudan Dyes) by Human Intestinal Microflora.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/12//
VL - 73
IS - 23
M3 - Article
SP - 7759
EP - 7762
SN - 00992240
AB - The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANAEROBIC bacteria
KW - ANAEROBIC metabolism
KW - BACTERIAL growth
KW - MICROBIAL growth
KW - MICROORGANISMS -- Population biology
KW - METABOLITES
KW - ANILINE
KW - LIQUID chromatography
KW - AROMATIC amines
N1 - Accession Number: 27973754; Haiyan Xu 1 Heinze, Thomas M. 2 Siwei Chen 1 Cerniglia, Carl E. 1 Huizhong Chen 1; Email Address: huizhong.chcn@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502; Source Info: Dec2007, Vol. 73 Issue 23, p7759; Subject Term: ANAEROBIC bacteria; Subject Term: ANAEROBIC metabolism; Subject Term: BACTERIAL growth; Subject Term: MICROBIAL growth; Subject Term: MICROORGANISMS -- Population biology; Subject Term: METABOLITES; Subject Term: ANILINE; Subject Term: LIQUID chromatography; Subject Term: AROMATIC amines; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 4p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1128/AEM.01410-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lories, Rik J. U.
AU - Peeters, Jenny
AU - Bakker, Astrid
AU - Tylzanowski, Przemko
AU - Derese, Inge
AU - Schrooten, Jan
AU - Thomas, J. Terrig
AU - Luyten, Frank P.
T1 - Articular Cartilage and Biomechanical Properties of the Long Bones in Frzb-Knockout Mice.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2007/12//
VL - 56
IS - 12
M3 - Article
SP - 4095
EP - 4103
SN - 00043591
AB - The article presents a study which examined cartilage and bone in Frzb mice. Results showed that articular cartilage loss during arthritis has increased after targeted deletion of the Frzb gene in mice. It was concluded that the genetic association between osteoarthritis and FRZB polymorphisms is corroborated by increased cartilage proteoglycan loss in different models of arthritis in mice.
KW - CARTILAGE
KW - BONE
KW - OSTEOARTHRITIS
KW - GENETIC polymorphisms
KW - GENETICS
KW - MICE
N1 - Accession Number: 28619065; Lories, Rik J. U. 1 Peeters, Jenny 1 Bakker, Astrid 1 Tylzanowski, Przemko 1 Derese, Inge 1 Schrooten, Jan 1 Thomas, J. Terrig 2 Luyten, Frank P. 1; Email Address: Frank.Luyten@uz.kuleuven.be; Affiliation: 1: University of Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium 2: Center for Biologics Evaluation and Research, FDA, Rockville, Mary-land; Source Info: Dec2007, Vol. 56 Issue 12, p4095; Subject Term: CARTILAGE; Subject Term: BONE; Subject Term: OSTEOARTHRITIS; Subject Term: GENETIC polymorphisms; Subject Term: GENETICS; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1002/art.23137
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28619065&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Smith, Derek R.
T1 - Journal impact factors: what do they mean for public health?
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 2007/12//
VL - 31
IS - 6
M3 - Letter
SP - 581
EP - 582
SN - 13260200
AB - A letter to the editor is presented about journal impact factors (JIF) and what they mean for public health.
KW - LETTERS to the editor
KW - PUBLIC health
N1 - Accession Number: 31381020; Smith, Derek R. 1; Email Address: smith@h.jniosh.go.jp; Affiliations: 1: National Institute of Occupational Safety and Health, Kawasaki, Japan; Issue Info: Dec2007, Vol. 31 Issue 6, p581; Subject Term: LETTERS to the editor; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Letter
L3 - 10.1111/j.1753-6405.2007.00148.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=31381020&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105921022
T1 - Widely used drugs that don't have FDA approval: serious side effects -- and even deaths -- have occurred.
AU - Levy M
Y1 - 2007/12//2007 Dec
N1 - Accession Number: 105921022. Language: English. Entry Date: 20080111. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. Special Interest: Consumer Health. NLM UID: 9891730.
KW - Drugs, Non-Prescription
KW - Drugs, Prescription
KW - Dosage Forms
KW - Drug Combinations
KW - Drugs, Off-Label
KW - Ergotamine
KW - Quinine
SP - 11
EP - 12
JO - Bottom Line Health
JF - Bottom Line Health
JA - BOTTOM LINE HEALTH
VL - 21
IS - 12
CY - Greenwich, Connecticut
PB - Health Confidential
SN - 1092-0129
AD - Director, Division of New Drugs and Labeling Compliance, Office of Compliance, FDA's Center for Drug Evaluation and Research, Washington, DC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105921022&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Caporaso, Neil
AU - Goldin, Lynn
AU - Plass, Christoph
AU - Calin, George
AU - Marti, Gerald
AU - Bauer, Steven
AU - Raveche, Elizabeth
AU - McMaster, Mary Lou
AU - Ng, David
AU - Landgren, Ola
AU - Slager, Susan
T1 - Chronic lymphocytic leukaemia genetics overview.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 630
EP - 634
PB - Wiley-Blackwell
SN - 00071048
AB - Although the familial aspect of chronic lymphocytic leukaemia (CLL) has been appreciated for decades, it is only with the recent confluence of improved molecular and gene technologies and world-wide collaborative networks that accelerated progress has become apparent. In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - GENETICS
KW - NANOTECHNOLOGY
KW - DISEASE susceptibility
KW - MOLECULAR epidemiology
KW - LYMPHOCYTES
KW - candidate genes
KW - chronic lymphocytic leukaemia
KW - family studies
KW - genetic association
KW - linkage
KW - susceptibility
N1 - Accession Number: 27476639; Caporaso, Neil 1; Email Address: caporaso@nih.gov Goldin, Lynn 1 Plass, Christoph 2 Calin, George 3 Marti, Gerald 4 Bauer, Steven 4 Raveche, Elizabeth 5 McMaster, Mary Lou 1 Ng, David 1 Landgren, Ola 1 Slager, Susan 6; Affiliation: 1: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 2: Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, the Comprehensive Cancer Center at The Ohio State University, Columbus, OH 3: Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 4: Cellular and Tissue Therapy Branch, Division of Cell and Gene Therapies, Office of Cellular Tissue and Gene Therapies, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD 5: New Jersey Medical School/University of Medicine and Dentistry of New Jersey, Newark, NJ 6: Mayo Clinic College of Medicine, Division of Biostatistics, Department of Health Sciences Research, Rochester, MN, USA; Source Info: Dec2007, Vol. 139 Issue 5, p630; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: GENETICS; Subject Term: NANOTECHNOLOGY; Subject Term: DISEASE susceptibility; Subject Term: MOLECULAR epidemiology; Subject Term: LYMPHOCYTES; Author-Supplied Keyword: candidate genes; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: family studies; Author-Supplied Keyword: genetic association; Author-Supplied Keyword: linkage; Author-Supplied Keyword: susceptibility; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06846.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476639&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scaglione, Brian J.
AU - Salerno, Erica
AU - Balan, Murugabaskar
AU - Coffman, Frederick
AU - Landgraf, Pablo
AU - Abbasi, Fatima
AU - Kotenko, Sergei
AU - Marti, Gerald E.
AU - Raveche, Elizabeth S.
T1 - Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 645
EP - 657
PB - Wiley-Blackwell
SN - 00071048
AB - Mouse models are valuable tools in the study of human chronic lymphocytic leukaemia (CLL). The New Zealand Black (NZB) strain is a naturally occurring model of late-onset CLL characterized by B-cell hyperproliferation and autoimmunity early in life, followed by progression to CLL. Other genetically engineered models of CLL that have been developed include (NZB × NZW) F1 mice engineered to express IL5, mice expressing human TCL1A, and mice overexpressing both BCL2 and a tumour necrosis factor receptor-associated factor. The applicability to human CLL varies with each model, suggesting that CLL is a multifactorial disease. Our work with the de novo NZB model has revealed many similarities to the human situation, particularly familial CLL. In NZB, the malignant clones express CD5, zap-70, and have chromosomal instability and germline Ig sequence. We also identified a point mutation in the 3′-flanking sequence of Mirn16-1, which resulted in decreased levels of the microRNA, miR-16 in lymphoid tissue. Exogenous restoration of miR-16 to an NZB malignant B-1 cell line resulted in cell cycle alterations, suggesting that the altered expression of Mirn15a/16-1 is an important molecular lesion in CLL. Future studies utilizing the NZB mouse could ascertain the role of environmental triggers, such as low dose radiation and organic chemicals in the augmentation of a pre-existing propensity to develop CLL. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANIMAL models in research
KW - CHRONIC lymphocytic leukemia
KW - RNA
KW - B cells
KW - CELL proliferation
KW - AUTOIMMUNITY
KW - TUMOR necrosis factor
KW - CELL lines
KW - microRNA
KW - mouse models of chronic lymphocytic leukaemia
KW - New Zealand Black
N1 - Accession Number: 27476637; Scaglione, Brian J. 1 Salerno, Erica 1 Balan, Murugabaskar 1 Coffman, Frederick 1 Landgraf, Pablo 2 Abbasi, Fatima 3 Kotenko, Sergei 1 Marti, Gerald E. 3 Raveche, Elizabeth S. 1; Email Address: raveches@umdnj.edu; Affiliation: 1: New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 2: Lab of RNA Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 3: Center by Biologics Evaluation and Research/FDA, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p645; Subject Term: ANIMAL models in research; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: RNA; Subject Term: B cells; Subject Term: CELL proliferation; Subject Term: AUTOIMMUNITY; Subject Term: TUMOR necrosis factor; Subject Term: CELL lines; Author-Supplied Keyword: microRNA; Author-Supplied Keyword: mouse models of chronic lymphocytic leukaemia; Author-Supplied Keyword: New Zealand Black; Number of Pages: 13p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06851.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shim, Youn K.
AU - Silver, Sharon R.
AU - Caporaso, Neil E.
AU - Marti, Gerald E.
AU - Middleton, Dannie C.
AU - Linet, Martha S.
AU - Vogt, Robert F.
T1 - B cells behaving badly.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 658
EP - 662
PB - Wiley-Blackwell
SN - 00071048
AB - The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - CARCINOGENESIS
KW - LYMPHOPROLIFERATIVE disorders
KW - CHRONIC lymphocytic leukemia
KW - CELLULAR immunity
KW - MONOCLONAL antibodies
KW - CELL-mediated lympholysis
KW - BIOCHEMICAL markers
KW - aetiology
KW - chronic lymphocytic leukaemia
KW - genetics
KW - monoclonal B-cell lymphocytosis
N1 - Accession Number: 27476642; Shim, Youn K. 1; Email Address: YShim@cdc.gov Silver, Sharon R. 2 Caporaso, Neil E. 3 Marti, Gerald E. 4 Middleton, Dannie C. 1 Linet, Martha S. 3 Vogt, Robert F. 5; Affiliation: 1: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 2: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 3: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 4: Office of Cellular, Tissue and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, Bethesda, MD, 5: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA; Source Info: Dec2007, Vol. 139 Issue 5, p658; Subject Term: B cells; Subject Term: CARCINOGENESIS; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: CELLULAR immunity; Subject Term: MONOCLONAL antibodies; Subject Term: CELL-mediated lympholysis; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: aetiology; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: genetics; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06842.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476642&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Linet, Martha S.
AU - Schubauer-Berigan, Mary K.
AU - Weisenburger, Dennis D.
AU - Richardson, David B.
AU - Landgren, Ola
AU - Blair, Aaron
AU - Silver, Sharon
AU - Field, R. William
AU - Caldwell, Glyn
AU - Hatch, Maureen
AU - Dores, Graça M.
T1 - Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesis.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 672
EP - 686
PB - Wiley-Blackwell
SN - 00071048
AB - This overview of the epidemiology of chronic lymphocytic leukaemia (CLL) summarizes the evolution of classification and coding systems and describes the intersection of pathogenesis and aetiology. The role of the putative precursor to CLL, monoclonal B-cell lymphocytosis (MBL), is considered, and ideas for future investigations of the MBL-CLL relationship are outlined. We discuss the epidemiology of CLL, focusing on descriptive patterns and methodological considerations. Postulated risk factors are reviewed including the role of ionizing and non-ionizing radiation, occupational and environmental chemical exposures, medical conditions and treatments, and lifestyle and genetic factors. We conclude by raising key questions that need to be addressed to advance our understanding of CLL aetiology. Recommendations for future epidemiological studies are given, including the standardization of reporting of CLL across cancer registries, the clarification of the natural history of MBL, and the circumvention of the methodological shortcomings of prior epidemiological investigations in relation to radiation, chemical exposures and infectious agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - DISEASES -- Causes & theories of causation
KW - CARCINOGENESIS
KW - EPIDEMIOLOGY
KW - MONOCLONAL antibodies
KW - B cells
KW - CELL-mediated lympholysis
KW - IONIZING radiation
KW - aetiology
KW - chemicals
KW - chronic lymphocytic leukaemia
KW - radiation
KW - review
N1 - Accession Number: 27476638; Linet, Martha S. 1; Email Address: linetm@mail.nih.gov Schubauer-Berigan, Mary K. 2 Weisenburger, Dennis D. 3 Richardson, David B. 4 Landgren, Ola 5 Blair, Aaron 6 Silver, Sharon 2 Field, R. William 7 Caldwell, Glyn 7 Hatch, Maureen 1 Dores, Graça M. 1; Affiliation: 1: DCEG/Radiation Epidemiology Branch, National Cancer Institute, Bethesda, MD 2: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 3: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 4: School of Public Health, University of North Carolina, Chapel Hill, NC 5: DCEG/Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 6: DCEG/Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 7: College of Public Health, University of Iowa, Iowa City, IA; Source Info: Dec2007, Vol. 139 Issue 5, p672; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: CARCINOGENESIS; Subject Term: EPIDEMIOLOGY; Subject Term: MONOCLONAL antibodies; Subject Term: B cells; Subject Term: CELL-mediated lympholysis; Subject Term: IONIZING radiation; Author-Supplied Keyword: aetiology; Author-Supplied Keyword: chemicals; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: radiation; Author-Supplied Keyword: review; Number of Pages: 15p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06847.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476638&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vogt, Robert F.
AU - Marti, Gerald E.
T1 - Overview of monoclonal gammopathies of undetermined significance.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 687
EP - 689
PB - Wiley-Blackwell
SN - 00071048
AB - Among the B-cell lymphoproliferative disorders, monoclonal gammopathy of undetermined significance (MGUS) is the humoral counterpart to monoclonal B-cell lymphocytosis. This review introduces the papers from the section devoted to MGUS at the International Workshop entitled ‘Monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia: environmental and genetic risk factors.’ [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL gammopathies
KW - B cells
KW - LYMPHOPROLIFERATIVE disorders
KW - CELL-mediated lympholysis
KW - CHRONIC lymphocytic leukemia
KW - MULTIPLE myeloma
KW - chronic lymphocytic leukaemia
KW - lymphoid malignancies
KW - multiple myeloma
KW - Waldenstrom macroglobulinaemia
N1 - Accession Number: 27476632; Vogt, Robert F. 1; Email Address: rvogt@cdc.gov Marti, Gerald E. 2; Affiliation: 1: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 2: Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p687; Subject Term: MONOCLONAL gammopathies; Subject Term: B cells; Subject Term: LYMPHOPROLIFERATIVE disorders; Subject Term: CELL-mediated lympholysis; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: MULTIPLE myeloma; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: lymphoid malignancies; Author-Supplied Keyword: multiple myeloma; Author-Supplied Keyword: Waldenstrom macroglobulinaemia; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06860.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476632&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vogt, Robert F.
AU - Shim, Youn K.
AU - Middleton, Dannie C.
AU - Buffler, Patricia A.
AU - Campolucci, Sharon S.
AU - Lybarger, Jeffrey A.
AU - Marti, Gerald E.
T1 - Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 690
EP - 700
PB - Wiley-Blackwell
SN - 00071048
AB - The first studies of monoclonal B-cell lymphocytosis (MBL) in the general population were conducted as part of environmental health investigations that began in 1991. MBL was observed as an unexpected finding when blood samples were immunophenotyped by two-colour flow cytometric methods in common use at that time. The initial observations led to a workshop in 1995, at which case definitions were considered and medical follow-up investigations were recommended. Medical follow-ups were conducted in 1997 and 2003. A total of eight cases of confirmed MBL and three cases of presumptive MBL were identified. This review summarizes the findings from those investigations and discusses the issues related to using MBL as a biomarker in environmental health research and population-based studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - B cells
KW - CELL-mediated lympholysis
KW - BIOCHEMICAL markers
KW - ENVIRONMENTAL health research
KW - FLOW cytometry
KW - PHENOTYPE
KW - OUTCOME assessment (Medical care)
KW - aetiology
KW - B-cell lymphoproliferative disorders
KW - chronic lymphocytic leukaemia
KW - epidemiology
KW - epidemiology.
KW - hazardous waste
N1 - Accession Number: 27476631; Vogt, Robert F. 1; Email Address: rvogt@cdc.gov Shim, Youn K. 2 Middleton, Dannie C. 2 Buffler, Patricia A. 3 Campolucci, Sharon S. 2 Lybarger, Jeffrey A. 2 Marti, Gerald E. 4; Affiliation: 1: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 2: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 3: University of California at Berkeley, School of Public Health, Berkeley, CA, 4: Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p690; Subject Term: MONOCLONAL antibodies; Subject Term: B cells; Subject Term: CELL-mediated lympholysis; Subject Term: BIOCHEMICAL markers; Subject Term: ENVIRONMENTAL health research; Subject Term: FLOW cytometry; Subject Term: PHENOTYPE; Subject Term: OUTCOME assessment (Medical care); Author-Supplied Keyword: aetiology; Author-Supplied Keyword: B-cell lymphoproliferative disorders; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: epidemiology.; Author-Supplied Keyword: hazardous waste; Number of Pages: 11p; Illustrations: 1 Black and White Photograph, 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06861.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476631&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marti, Gerald
AU - Abbasi, Fatima
AU - Raveche, Elizabeth
AU - Rawstron, Andy C.
AU - Ghia, Paolo
AU - Aurran, Therese
AU - Caporaso, Neil
AU - Shim, Youn K.
AU - Vogt, Robert F.
T1 - Overview of monoclonal B-cell lymphocytosis.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 701
EP - 708
PB - Wiley-Blackwell
SN - 00071048
AB - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - B cells
KW - CELL-mediated lympholysis
KW - CHRONIC lymphocytic leukemia
KW - OLDER people -- Diseases
KW - DISEASES -- Causes & theories of causation
KW - ENVIRONMENTAL health
KW - chronic lymphocytic leukaemia
KW - monoclonal B-cell lymphocytosis
N1 - Accession Number: 27476627; Marti, Gerald 1; Email Address: gemarti@helix.nih.gov Abbasi, Fatima 1 Raveche, Elizabeth 2 Rawstron, Andy C. 3 Ghia, Paolo 4 Aurran, Therese 5 Caporaso, Neil 6 Shim, Youn K. 7 Vogt, Robert F. 8; Affiliation: 1: Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD 2: NJ Med School/UMDNJ, Newark, NJ, USA 3: Haematological Malignancy Diagnostic Service, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK 4: Unit of Lymphoid Malignancies, Department of Oncology, Università Vita-Salute San Raffaele, Milano, Italy 5: Institut Paoli-Calmettes, Marseille Cedex9, France 6: Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, NIH, Bethesda, MD 7: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 8: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA; Source Info: Dec2007, Vol. 139 Issue 5, p701; Subject Term: MONOCLONAL antibodies; Subject Term: B cells; Subject Term: CELL-mediated lympholysis; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: OLDER people -- Diseases; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: ENVIRONMENTAL health; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Number of Pages: 8p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06865.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476627&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schubauer-Berigan, Mary K.
AU - Daniels, Robert D.
AU - Fleming, Donald A.
AU - Markey, Andrea M.
AU - Couch, James R.
AU - Ahrenholz, Steven H.
AU - Burphy, Jenneh S.
AU - Anderson, Jeri L.
AU - Tseng, Chih-Yu
T1 - Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 799
EP - 808
PB - Wiley-Blackwell
SN - 00071048
AB - The aetiology of chronic lymphocytic leukaemia (CLL) is largely unknown. Despite compelling evidence for ionising radiation as a cause of most forms of leukaemia, CLL was not found to be radiogenic in early studies. Herein we describe the recent evidence for causation of CLL by ionising and non-ionising radiation, including a nested case-control study conducted within a cohort of 94 517 US workers at four nuclear weapons facilities and a nuclear naval shipyard. Forty-three cases of CLL deaths and 172 age-matched controls were identified with follow-up up to between 1990 and 1996. Radiation exposure from external sources and plutonium (lagged 10 years) was assessed for each worker, based on monitoring records. The excess relative rate (ERR) was estimated for workers receiving elevated doses compared to unexposed workers, controlling for possible risk factors. The ERR per 10 mSv was −0·020 (95% confidence interval: <0, 0·14) based on all exposed workers. However, for workers receiving <100 mSv, the ERR per 10 mSv was 0·20 (−0·035, 0·96). Recent studies of uranium miners and other populations have shown elevations of CLL possibly associated with ionising and non-ionising radiation. New studies should use incident cases and sufficient latency to account for the expected lengthy induction period for CLL. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - RADIATION
KW - NUCLEAR power plants -- Employees
KW - NUCLEAR facilities
KW - DISEASES -- Causes & theories of causation
KW - NUCLEAR weapons
KW - PLUTONIUM
KW - URANIUM
KW - aetiology
KW - chronic lymphocytic leukaemia
KW - epidemiology
N1 - Accession Number: 27476641; Schubauer-Berigan, Mary K. 1; Email Address: zcg3@cdc.gov Daniels, Robert D. 1 Fleming, Donald A. 1 Markey, Andrea M. 1 Couch, James R. 1 Ahrenholz, Steven H. 1 Burphy, Jenneh S. 1 Anderson, Jeri L. 1 Tseng, Chih-Yu 1; Affiliation: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH, USA; Source Info: Dec2007, Vol. 139 Issue 5, p799; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: RADIATION; Subject Term: NUCLEAR power plants -- Employees; Subject Term: NUCLEAR facilities; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: NUCLEAR weapons; Subject Term: PLUTONIUM; Subject Term: URANIUM; Author-Supplied Keyword: aetiology; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: epidemiology; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 213119 Other support activities for mining; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06843.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476641&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abbasi, Fatima
AU - Longo, Nancy S.
AU - Lipsky, Peter E.
AU - Raveche, Elizabeth
AU - Schleinitz, Therese A.
AU - Stetler-Stevenson, Maryalice
AU - Caporaso, Neil
AU - Marti, Gerald
T1 - B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 820
EP - 823
PB - Wiley-Blackwell
SN - 00071048
AB - Monoclonal B cell lymphocytosis (MBL) was detected in four unaffected first-degree relatives (FDR) in a familial chronic lymphocytic leukaemia (CLL) kindred. The proband remains untreated and two male siblings have died. The four unaffected siblings have been followed for a five-year period. All four FDR developed a kappa+CD5+ MBL detected by flow cytometry. Poymerase chain reaction (PCR) for IGHV rearrangement showed evidence of oligoclonality in three of these individuals. Single cell PCR of flow cytometric sorted kappa+ cells combined with Ig kappa light chain gene sequencing revealed further evidence of monoclonality in two of these individuals. Three of these individuals all showed evidence of hyper-somatic mutations. The B-cell repertoire in unaffected FDR in familial CLL offers a new area to investigate the interface between the immune system and lymphoid neoplasm. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - B cells
KW - FAMILIAL diseases
KW - CHRONIC lymphocytic leukemia
KW - MONOCLONAL antibodies
KW - CELL-mediated lympholysis
KW - FLOW cytometry
KW - POLYMERASE chain reaction
KW - IMMUNOGLOBULIN genes
KW - chronic lymphocytic leukaemia
KW - clonality
KW - monoclonal B-cell lymphocytosis
N1 - Accession Number: 27476634; Abbasi, Fatima 1 Longo, Nancy S. 2 Lipsky, Peter E. 2 Raveche, Elizabeth 3 Schleinitz, Therese A. 4 Stetler-Stevenson, Maryalice 5 Caporaso, Neil 6 Marti, Gerald 1; Email Address: gemarti@helix.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, NIH, Bethesda, MD 2: Repertoire Analysis Group, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NJ, USA 3: NJ Med School/UMDNJ, Newark, NJ, USA 4: Institut Paoli-Calmettes, Marseille Cedex, France 5: Laboratory of Pathology, NCI, NIH, USA 6: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p820; Subject Term: B cells; Subject Term: FAMILIAL diseases; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: MONOCLONAL antibodies; Subject Term: CELL-mediated lympholysis; Subject Term: FLOW cytometry; Subject Term: POLYMERASE chain reaction; Subject Term: IMMUNOGLOBULIN genes; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: clonality; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06857.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476634&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hardy, Nancy M.
AU - Grady, Christine
AU - Pentz, Rebecca
AU - Stetler-Stevenson, Maryalice
AU - Raffeld, Mark
AU - Fontaine, Laura S.
AU - Babb, Rebecca
AU - Bishop, Michael R.
AU - Caporaso, Neil
AU - Marti, Gerald E.
T1 - Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 824
EP - 831
PB - Wiley-Blackwell
SN - 00071048
AB - Monoclonal B-cell lymphocytosis (MBL) is a recently described laboratory finding in otherwise healthy individuals. In MBL, a light chain-restricted, clonal B-cell population, often with a chronic lymphocytic leukaemia (CLL) phenotype, is identified by flow cytometry. Although the prognostic significance remains unclear, there is an increased incidence in ageing populations and those with a family history of CLL. During the past decade of MBL study, three families have come to our attention in which prospective sibling haematopoietic stem cell donors were found to have an MBL. These families raise complex bioethical issues with regard to disclosure of research data, eligibility for clinical trials and potential donor transfer of MBL. These issues are explored in this report. Identification of MBL among prospective sibling transplant donors will become a common occurrence in transplant practice as transplantation is increasingly offered to older individuals and those with CLL. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOETHICS
KW - MONOCLONAL antibodies
KW - B cells
KW - CELL-mediated lympholysis
KW - HEMATOPOIETIC stem cells -- Transplantation
KW - CHRONIC lymphocytic leukemia
KW - PHENOTYPE
KW - FLOW cytometry
KW - chronic lymphocytic leukaemia
KW - ethics
KW - stem cell transplantation
N1 - Accession Number: 27476630; Hardy, Nancy M. 1 Grady, Christine 2 Pentz, Rebecca 3 Stetler-Stevenson, Maryalice 4 Raffeld, Mark 4 Fontaine, Laura S. 5 Babb, Rebecca 6 Bishop, Michael R. 1 Caporaso, Neil 7 Marti, Gerald E. 8; Email Address: gemarti@helix.nih.gov; Affiliation: 1: Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 2: Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 3: Winship Cancer Institute, Emory University, Atlanta, GA 4: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 5: Westat, Inc, Rockville, MD 6: Department of Nursing, Clinical Center, National Institutes of Health, Bethesda, MD, USA 7: Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 8: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p824; Subject Term: BIOETHICS; Subject Term: MONOCLONAL antibodies; Subject Term: B cells; Subject Term: CELL-mediated lympholysis; Subject Term: HEMATOPOIETIC stem cells -- Transplantation; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: PHENOTYPE; Subject Term: FLOW cytometry; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: ethics; Author-Supplied Keyword: stem cell transplantation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06862.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476630&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rachel, Jane M.
AU - Zucker, Marjorie L.
AU - Fox, Christopher M.
AU - Plapp, Fred V.
AU - Menitove, Jay E.
AU - Abbasi, Fatima
AU - Marti, Gerald E.
T1 - Monoclonal B-cell lymphocytosis in blood donors.
JO - British Journal of Haematology
JF - British Journal of Haematology
Y1 - 2007/12//
VL - 139
IS - 5
M3 - Article
SP - 832
EP - 836
PB - Wiley-Blackwell
SN - 00071048
AB - Monoclonal B-cell populations have been detected in the peripheral blood of apparently healthy individuals by flow cytometry. In 2005, the term monoclonal B-cell lymphocytosis (MBL) was proposed to describe these findings. MBL may be immunophenotypically similar to chronic lymphocytic leukaemia (CLL) and, like CLL, the prevalence is higher in males and older individuals. We studied the prevalence of MBL in blood donors from the Midwestern United States. Samples from 5141 donors were examined and seven (0·14%) were found to have immunophenotypic characteristics of MBL or CLL. Immunoglobulin heavy chain analysis yielded monoclonality or oligoclonality. Prior and subsequent to the study, an additional undetermined number of blood donors were screened and seven of these expressed immunophenotypic characteristics of MBL or CLL. We thus found a total of 14 healthy blood donors with monoclonal expansions of B-lymphocyte populations. Of these, 12 were presumptively classified as MBL and two as CLL. All but two of the donors were male; the mean age was 59 years. The clinical importance of these findings with regard to transfusion medicine has not been established. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated lympholysis
KW - B cells
KW - BLOOD donors
KW - PHENOTYPE
KW - CHRONIC lymphocytic leukemia
KW - IMMUNOGLOBULINS
KW - BLOOD transfusion
KW - UNITED States
KW - blood donors
KW - chronic lymphocytic leukaemia
KW - flow cytometry
KW - flow cytometry.
KW - monoclonal B-cell lymphocytosis
N1 - Accession Number: 27476623; Rachel, Jane M. 1; Email Address: jrachel@saint-lukes.org Zucker, Marjorie L. 1 Fox, Christopher M. 1 Plapp, Fred V. 1 Menitove, Jay E. 2 Abbasi, Fatima 3 Marti, Gerald E. 3; Affiliation: 1: Saint Luke's Hospital, Kansas City, MO 2: Community Blood Center, Kansas City, MO 3: Flow and Image Cytometry Laboratory, Cellular Therapy and Tissues Branch, Division of Gene and Cell Therapy, US Food and Drug Administration/Center for Biologics Evaluation and Research, NIH, Bethesda, MD, USA; Source Info: Dec2007, Vol. 139 Issue 5, p832; Subject Term: CELL-mediated lympholysis; Subject Term: B cells; Subject Term: BLOOD donors; Subject Term: PHENOTYPE; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: IMMUNOGLOBULINS; Subject Term: BLOOD transfusion; Subject Term: UNITED States; Author-Supplied Keyword: blood donors; Author-Supplied Keyword: chronic lymphocytic leukaemia; Author-Supplied Keyword: flow cytometry; Author-Supplied Keyword: flow cytometry.; Author-Supplied Keyword: monoclonal B-cell lymphocytosis; Number of Pages: 5p; Illustrations: 1 Black and White Photograph, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2141.2007.06870.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27476623&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Jing
AU - Ding, Min
AU - Yang, Lily
AU - Liu, Ling-Zhi
AU - Jiang, Bing-Hua
T1 - PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
JO - Cellular Signalling
JF - Cellular Signalling
Y1 - 2007/12//
VL - 19
IS - 12
M3 - Article
SP - 2487
EP - 2497
SN - 08986568
AB - Abstract: PI3K pathway exerts its function through its downstream molecule AKT in regulating various cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth and angiogenesis. PTEN is an inhibitor of PI3K, and its loss or mutation is common in human prostate cancer. But the direct role and mechanism of PI3K/PTEN signaling in regulating angiogenesis and tumor growth in vivo remain to be elucidated. In this study, by using chicken chorioallantoic membrane (CAM) and in nude mice models, we demonstrated that inhibition of PI3K activity by LY294002 decreased PC-3 cells-induced angiogenesis. Reconstitution of PTEN, the molecular inhibitor of PI3K in PC-3 cells inhibited angiogenesis and tumor growth. Immunohistochemical staining indicated that PTEN expression suppressed HIF-1α, VEGF and PCNA expression in the tumor xenographs. Similarly, expression of AKT dominant negative mutant also inhibited angiogenesis and tumor growth, and decreased the expression of HIF-1α and VEGF in the tumor xenographs. These results suggest that inhibition of PI3K signaling pathway by PTEN inhibits tumor angiogenesis and tumor growth. In addition, we found that AKT is the downstream target of PI3K in controlling angiogenesis and tumor growth, and PTEN could inhibit angiogenesis by regulating the expression of HIF-1 and VEGF expression through AKT activation in PC-3 cells. [Copyright &y& Elsevier]
AB - Copyright of Cellular Signalling is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEOVASCULARIZATION
KW - CELL populations
KW - EXOCRINE glands
KW - APOPTOSIS
KW - AKT
KW - chicken chorioallantoic membrane ( CAM )
KW - Hypoxia inducible factor 1
KW - microvessel density ( MVD )
KW - multiplicity of infection. ( MOI )
KW - phosphatidylinsitol 3-kinase ( PI3K )
KW - PTEN
KW - Vascular endothelial growth factor
N1 - Accession Number: 26995855; Fang, Jing 1 Ding, Min 2 Yang, Lily 3 Liu, Ling-Zhi 1 Jiang, Bing-Hua 1; Email Address: bhjiang@hsc.wvu.edu; Affiliation: 1: Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506-9300, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 3: Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Source Info: Dec2007, Vol. 19 Issue 12, p2487; Subject Term: NEOVASCULARIZATION; Subject Term: CELL populations; Subject Term: EXOCRINE glands; Subject Term: APOPTOSIS; Author-Supplied Keyword: AKT; Author-Supplied Keyword: chicken chorioallantoic membrane ( CAM ); Author-Supplied Keyword: Hypoxia inducible factor 1; Author-Supplied Keyword: microvessel density ( MVD ); Author-Supplied Keyword: multiplicity of infection. ( MOI ); Author-Supplied Keyword: phosphatidylinsitol 3-kinase ( PI3K ); Author-Supplied Keyword: PTEN; Author-Supplied Keyword: Vascular endothelial growth factor; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.cellsig.2007.07.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scott, Susana
AU - Moss, William J.
AU - Cousens, Simon
AU - Beeler, Judy A.
AU - Audet, Susette A.
AU - Mugala, Nanthalile
AU - Quinn, Thomas C.
AU - Griffin, Diane E.
AU - Cutts, Felicity T.
T1 - The Influence of HIV-1 Exposure and Infection on Levels of Passively Acquired Antibodies to Measles Virus in Zambian Infants.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/12//12/1/2007
VL - 45
IS - 11
M3 - Article
SP - 1417
EP - 1424
SN - 10584838
AB - Background. The age at which passively acquired antibodies are lost is critical to determining the optimal age for measles vaccination. Little is known about the influence of human immunodeficiency virus type 1 (HIV-1) infection on levels of prevaccination antibodies to measles virus. Methods. Antibodies to measles virus were measured by plaque reduction neutralization assay in HIV-1-infected, HIV-seropositive but uninfected, and HIV-seronegative Zambian infants aged 6 weeks to 9 months. Regression models were used to estimate age-specific antibody concentrations. Results. Neutralizing antibodies to measles virus were measured in 652 plasma samples collected from 448 infants, of whom 61 (13.6%) were HIV-1 infected, 239 (53.4%) were HIV seropositive but uninfected, and 148 (33%) were HIV seronegative. The best fitting model suggests that HIV-1-infected infants have lower levels of passively acquired antibodies to measles virus at birth than do HIV-seronegative infants, but their antibody levels decrease more slowly. By 6 months of age, 91% (95% confidence interval, 83%-99%) of HIV-1-infected infants, 83% (95% confidence interval, 77%-89%) of HIV-seropositive but uninfected infants, and 58% (95% confidence interval, 51%-64%) of HIV-seronegative infants were estimated to have antibody levels that were unlikely to affect immune responses to measles vaccine (cutoff value for immune response, <50 mIU/mL). By 9 months of age, 99% of all infants had antibody levels !50 mIU/mL. Conclusions. Infants born to HIV-1-infected women are less likely to have passively acquired antibodies that would neutralize measles vaccine virus and, thus, have an increased risk of measles prior to the age of routine vaccination. Protection could be achieved by administration of the first dose of measles vaccine prior to 9 months of age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - HIV (Viruses)
KW - Immunoglobulins
KW - Measles
KW - Measles virus
KW - Vaccination of infants
KW - Preventive medicine
KW - Zambia
N1 - Accession Number: 28158006; Scott, Susana 1; Email Address: Susana.scott@lshtm.ac.uk; Moss, William J. 2; Cousens, Simon 1; Beeler, Judy A. 3; Audet, Susette A. 3; Mugala, Nanthalile 4; Quinn, Thomas C. 2; Griffin, Diane E. 2; Cutts, Felicity T. 1; Affiliations: 1: London School of Hygiene and Tropical Medicine, London, United Kingdom; 2: Bloomberg School of Public Health, Johns Hopkins University, Baltimore; 3: Food and Drug Administration, Rockville, Maryland; 4: Virology Laboratory, University Teaching Hospital, Lusaka, Zambia; Issue Info: 12/1/2007, Vol. 45 Issue 11, p1417; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Thesaurus Term: HIV (Viruses); Subject Term: Immunoglobulins; Subject Term: Measles; Subject Term: Measles virus; Subject Term: Vaccination of infants; Subject Term: Preventive medicine; Subject: Zambia; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/522989
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=28158006&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scott, Susana
AU - Moss, William J.
AU - Cousens, Simon
AU - Beeler, Judy A.
AU - Audet, Susette A.
AU - Mugala, Nanthalile
AU - Quinn, Thomas C.
AU - Griffin, Diane E.
AU - Cutts, Felicity T.
T1 - The Influence of HIV-1 Exposure and Infection on Levels of Passively Acquired Antibodies to Measles Virus in Zambian Infants.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2007/12//12/1/2007
VL - 45
IS - 11
M3 - Article
SP - 1417
EP - 1424
SN - 10584838
AB - Background. The age at which passively acquired antibodies are lost is critical to determining the optimal age for measles vaccination. Little is known about the influence of human immunodeficiency virus type 1 (HIV-1) infection on levels of prevaccination antibodies to measles virus. Methods. Antibodies to measles virus were measured by plaque reduction neutralization assay in HIV-1-infected, HIV-seropositive but uninfected, and HIV-seronegative Zambian infants aged 6 weeks to 9 months. Regression models were used to estimate age-specific antibody concentrations. Results. Neutralizing antibodies to measles virus were measured in 652 plasma samples collected from 448 infants, of whom 61 (13.6%) were HIV-1 infected, 239 (53.4%) were HIV seropositive but uninfected, and 148 (33%) were HIV seronegative. The best fitting model suggests that HIV-1-infected infants have lower levels of passively acquired antibodies to measles virus at birth than do HIV-seronegative infants, but their antibody levels decrease more slowly. By 6 months of age, 91% (95% confidence interval, 83%-99%) of HIV-1-infected infants, 83% (95% confidence interval, 77%-89%) of HIV-seropositive but uninfected infants, and 58% (95% confidence interval, 51%-64%) of HIV-seronegative infants were estimated to have antibody levels that were unlikely to affect immune responses to measles vaccine (cutoff value for immune response, <50 mIU/mL). By 9 months of age, 99% of all infants had antibody levels !50 mIU/mL. Conclusions. Infants born to HIV-1-infected women are less likely to have passively acquired antibodies that would neutralize measles vaccine virus and, thus, have an increased risk of measles prior to the age of routine vaccination. Protection could be achieved by administration of the first dose of measles vaccine prior to 9 months of age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MEASLES -- Vaccination
KW - MEASLES virus
KW - VACCINATION
KW - HIV (Viruses)
KW - VACCINATION of infants
KW - PREVENTIVE medicine
KW - ZAMBIA
N1 - Accession Number: 28158006; Scott, Susana 1; Email Address: Susana.scott@lshtm.ac.uk Moss, William J. 2 Cousens, Simon 1 Beeler, Judy A. 3 Audet, Susette A. 3 Mugala, Nanthalile 4 Quinn, Thomas C. 2 Griffin, Diane E. 2 Cutts, Felicity T. 1; Affiliation: 1: London School of Hygiene and Tropical Medicine, London, United Kingdom 2: Bloomberg School of Public Health, Johns Hopkins University, Baltimore 3: Food and Drug Administration, Rockville, Maryland 4: Virology Laboratory, University Teaching Hospital, Lusaka, Zambia; Source Info: 12/1/2007, Vol. 45 Issue 11, p1417; Subject Term: IMMUNOGLOBULINS; Subject Term: MEASLES -- Vaccination; Subject Term: MEASLES virus; Subject Term: VACCINATION; Subject Term: HIV (Viruses); Subject Term: VACCINATION of infants; Subject Term: PREVENTIVE medicine; Subject Term: ZAMBIA; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/522989
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28158006&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - The Path of the Minimum lp-Norm Estimator for p Between 1 and Infinity.
JO - Communications in Statistics: Theory & Methods
JF - Communications in Statistics: Theory & Methods
Y1 - 2007/12//
VL - 36
IS - 16
M3 - Article
SP - 2829
EP - 2839
SN - 03610926
AB - The minimum lp-norm estimator is the point that minimizes the sum of the distance from each data point in the lp-norm. The path of this location estimate for an lp-norm is found as p goes from 1 to infinity. This path indicates how critical the selection of an exponent is. An alternative proof of Descartes's rule of signs, applied to exponential sums, limits the number of repeated exponents for the same minimum point with usual data sets. Several bounds on this path include that it stays among the averages of pairs of data points. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications in Statistics: Theory & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - MULTIVARIATE analysis
KW - MATHEMATICAL models
KW - EXPONENTIAL sums
KW - SEQUENCES (Mathematics)
KW - NUMERICAL functions
KW - Descartes's rule of signs
KW - Equal sums of like powers
KW - Exponential sums
KW - Linear combinations of exponentials
KW - Norms
KW - Prohet-Tarry-Escott problem
N1 - Accession Number: 27625683; Blodgett, Robert J. 1; Email Address: robert.blodgett@fda.hhs.gov; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA; Issue Info: Dec2007, Vol. 36 Issue 16, p2829; Thesaurus Term: SAMPLING (Statistics); Thesaurus Term: MULTIVARIATE analysis; Thesaurus Term: MATHEMATICAL models; Subject Term: EXPONENTIAL sums; Subject Term: SEQUENCES (Mathematics); Subject Term: NUMERICAL functions; Author-Supplied Keyword: Descartes's rule of signs; Author-Supplied Keyword: Equal sums of like powers; Author-Supplied Keyword: Exponential sums; Author-Supplied Keyword: Linear combinations of exponentials; Author-Supplied Keyword: Norms; Author-Supplied Keyword: Prohet-Tarry-Escott problem; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 11p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1080/03610920701386950
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Finlayson, Tracy L.
AU - Siefert, Kristine
AU - Ismail, Amid I.
AU - Sohn, Woosung
T1 - Psychosocial factors and early childhood caries among low-income African–American children in Detroit.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 2007/12//
VL - 35
IS - 6
M3 - Article
SP - 439
EP - 448
SN - 03015661
AB - Objectives: This study sought to advance knowledge of the social determinants of oral health, by examining how several specific maternal health beliefs, behaviors, and psychosocial factors relate to young children's early childhood caries (ECC) status in a lower-income African–American population. Methods: Data were collected by the Detroit Dental Health Project (NIDCR grant), a population-based study of 1021 African–American families with at least one child under 6 years of age and living in 39 low-income Census tracts in Detroit, Michigan. Analyses were limited to 719 children aged 1–5 years and their biological mothers, and conducted in SUDAAN to account for the complex sampling design. Survey data included health belief scales on mothers’ self-efficacy, feelings of fatalism, knowledge about appropriate bottle use and children's oral hygiene needs, brushing habits, psychosocial measures of depressive symptoms (CES-D), parenting stress, and availability of instrumental social support. The child's age, dental insurance status, dental visit history, and 1-week brushing frequency were also included in the model. Children's ECC status, based on a dental examination, was the main outcome. The dental team used the International Caries Detection and Assessment System (ICDAS) criteria for caries detection. Each child was classified as either caries-free or having ECC or severe ECC (S-ECC) based on the case definition of ECC proposed by an expert panel for research purposes with preschool-aged children. Results: The dental team followed a specific examination protocol and established reliable and consistent ratings of ECC based on the ICDAS criteria. The inter-rater reliability kappa was 0.83 overall, and the intra-rater reliability kappa was 0.74 overall. One-third of the children had ECC, and 20% had severe ECC. Age of the child and lower parenting stress scores were each positively associated with ECC, while higher education and income were protective. Maternal oral health fatalism and knowledge of children's hygiene needs were associated with ECC among preschool-aged children. ECC was higher among younger children who had past restorative care. Conclusions: These findings call attention to the high prevalence of ECC in this population and the need to consider psychosocial as well as traditional risk factors in developing interventions to reduce oral health disparities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL caries
KW - PSYCHOSOCIAL factors
KW - DENTAL care
KW - INCOME
KW - AFRICAN American children
KW - DETROIT (Mich.)
KW - MICHIGAN
KW - African–American
KW - African-American
KW - Early Childhood Caries (ECC)
KW - International Caries Detection and Assessment System (ICDAS)
KW - parenting stress
KW - preschool aged children
KW - psychological factors
N1 - Accession Number: 27609019; Finlayson, Tracy L. 1; Email Address: tracyf@berkeley.edu Siefert, Kristine 2 Ismail, Amid I. 3 Sohn, Woosung 3; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ), Scholar, School of Public Health, University of California, Berkeley, CA 2: School of Social Work, NIMH Research Center on Poverty, Risk, and Mental Health, University of Michigan, Ann Arbor, MI 3: School of Dentistry, University of Michigan, Ann Arbor, MI, USA; Source Info: Dec2007, Vol. 35 Issue 6, p439; Subject Term: DENTAL caries; Subject Term: PSYCHOSOCIAL factors; Subject Term: DENTAL care; Subject Term: INCOME; Subject Term: AFRICAN American children; Subject Term: DETROIT (Mich.); Subject Term: MICHIGAN; Author-Supplied Keyword: African–American; Author-Supplied Keyword: African-American; Author-Supplied Keyword: Early Childhood Caries (ECC); Author-Supplied Keyword: International Caries Detection and Assessment System (ICDAS); Author-Supplied Keyword: parenting stress; Author-Supplied Keyword: preschool aged children; Author-Supplied Keyword: psychological factors; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1600-0528.2006.00352.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105844088
T1 - Psychosocial factors and early childhood caries among low-income African-American children in Detroit.
AU - Finlayson TL
AU - Siefert K
AU - Ismail AI
AU - Sohn W
Y1 - 2007/12//
N1 - Accession Number: 105844088. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed; Public Health. Special Interest: Dental Care; Public Health. NLM UID: 0410263.
KW - Attitude to Health
KW - Blacks -- Psychosocial Factors
KW - Dental Caries -- Psychosocial Factors
KW - Mothers -- Psychosocial Factors
KW - Adult
KW - Child, Preschool
KW - Dental Caries -- Epidemiology
KW - Female
KW - Infant
KW - Logistic Regression
KW - Michigan
KW - Parenting
KW - Prevalence
KW - Questionnaires
KW - Risk Factors
KW - Socioeconomic Factors
KW - Human
SP - 439
EP - 448
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
JA - COMMUNITY DENT ORAL EPIDEMIOL
VL - 35
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0301-5661
AD - Agency for Healthcare Research and Quality (AHRQ), Scholar, School of Public Health, University of California, Berkeley, CA
U2 - PMID: 18039285.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Misbin, Robert I.
T1 - Lessons From the Avandia Controversy.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2007/12//
VL - 30
IS - 12
M3 - Editorial
SP - 3141
EP - 3144
SN - 01495992
AB - The author highlights the problems with the approval process that are illustrated by Avandia and suggests a new paradigm for the development of drugs to treat type 2 diabetes. He believes that the approval of drugs to treat type 2 diabetes should continue to be based on change in A1C and that a dedicated safety trial should be completed before approval. He states that failure to complete the pivotal trials should be posted on the Web site of the U.S. Food and Drug Administration (FDA).
KW - DRUG approval
KW - NON-insulin-dependent diabetes -- Treatment
KW - GLYCOSYLATED hemoglobin
KW - UNITED States
KW - GLAXOSMITHKLINE
N1 - Accession Number: 28021224; Misbin, Robert I. 1; Email Address: robert.misbin@fda.hhs.gov; Affiliation: 1: Division of Endocrinology and Metabolism, Food and Drug Administration, Silver Spring, Maryland; Source Info: Dec2007, Vol. 30 Issue 12, p3141; Subject Term: DRUG approval; Subject Term: NON-insulin-dependent diabetes -- Treatment; Subject Term: GLYCOSYLATED hemoglobin; Subject Term: UNITED States; Company/Entity: GLAXOSMITHKLINE; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105827163
T1 - Lessons from the Avandia controversy: a new paradigm for the development of drugs to treat type 2 diabetes.
AU - Misbin RI
Y1 - 2007/12//
N1 - Accession Number: 105827163. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7805975.
KW - Diabetes Mellitus, Type 2 -- Drug Therapy
KW - Thiazolidinediones -- Adverse Effects
KW - Thiazolidinediones -- Therapeutic Use
KW - Clinical Trials -- Standards
KW - Drug Approval
KW - Hypoglycemic Agents -- Adverse Effects
KW - Hypoglycemic Agents -- Therapeutic Use
KW - Meta Analysis
KW - United States
KW - United States Food and Drug Administration
SP - 3141
EP - 3144
JO - Diabetes Care
JF - Diabetes Care
JA - DIABETES CARE
VL - 30
IS - 12
CY - Alexandria, Virginia
PB - American Diabetes Association
SN - 0149-5992
AD - Division of Endocrinology and Metabolism, Food and Drug Administration, Silver Spring, Maryland, USA. robert.misbin@fda.hhs.gov
U2 - PMID: 18042753.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jay, Michele T.
AU - Cooley, Michael
AU - Carychao, Diana
AU - Wiscomb, Gerald W.
AU - Sweitzer, Richard A.
AU - Crawford-Miksza, Leta
AU - Farrar, Jeff A.
AU - Lau, David K.
AU - O'Connell, Janice
AU - Millington, Anne
AU - Asmundson, Roderick V.
AU - Atwill, Edward R.
AU - Mandrell, Robert E.
T1 - Escherichia coli O157:H7 in Feral Swine near Spinach Fields and Cattle, Central California Coast.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/12//
VL - 13
IS - 12
M3 - Article
SP - 1908
EP - 1911
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We investigated involvement of feral swine in contamination of agricultural fields and surface waterways with Escherichia coli O157:H7 after a nationwide outbreak traced to bagged spinach from California. Isolates from feral swine, cattle, surface water, sediment, and soil at 1 ranch were matched to the outbreak strain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Feral swine
KW - Cattle
KW - Soils
KW - Escherichia coli O157:H7
KW - Spinach
KW - California
N1 - Accession Number: 27773770; Jay, Michele T. 1,2; Email Address: michele.jayrussell@cdph.ca.gov; Cooley, Michael 3; Carychao, Diana 3; Wiscomb, Gerald W. 4; Sweitzer, Richard A. 5; Crawford-Miksza, Leta 1; Farrar, Jeff A. 6; Lau, David K. 7; O'Connell, Janice 1; Millington, Anne 6; Asmundson, Roderick V. 7; Atwill, Edward R. 2; Mandrell, Robert E. 3; Affiliations: 1: California Department of Public Health, Richmond, California, USA; 2: University of California, Davis, California, USA; 3: US Department of Agriculture, Albany, California, USA; 4: US Department of Agriculture, Sacramento, California, USA; 5: University of North Dakota, Grand Forks, North Dakota, USA; 6: California Department of Public Health, Sacramento, California, USA; 7: US Food and Drug Administration, Alameda, California, USA; Issue Info: Dec2007, Vol. 13 Issue 12, p1908; Thesaurus Term: Feral swine; Thesaurus Term: Cattle; Thesaurus Term: Soils; Subject Term: Escherichia coli O157:H7; Subject Term: Spinach; Subject: California; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Diagram, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zheng, Jie
AU - Keys, Christine E.
AU - Zhao, Shaohua
AU - Meng, Jianghong
AU - Brown, Eric W.
T1 - Enhanced Subtyping Scheme for Salmonella Enteritidis.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2007/12//
VL - 13
IS - 12
M3 - Article
SP - 1932
EP - 1935
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - To improve pulsed-field gel electrophoresis-based strain discrimination of 76 Salmonella Enteritidis strains, we evaluated 6 macro-restriction endonucleases, separately and in various combinations. One 3-enzyme subset, Sfi I/PacI/NotI, was highly discriminatory. Five different indices, including the Simpson diversity index, supported this 3-enzyme combination for improved differentiation of S. Enteritidis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Enterobacteriaceae
KW - Salmonella enteritidis
KW - Pulsed-field gel electrophoresis
KW - Endonucleases
KW - Enzymes
N1 - Accession Number: 27773777; Zheng, Jie 1; Email Address: eric.brown@fda.hhs.gov; Keys, Christine E. 2; Zhao, Shaohua 3; Meng, Jianghong 1; Brown, Eric W. 2; Affiliations: 1: University of Maryland, College Park, Maryland, USA; 2: US Food and Drug Administration, College Park, Maryland, USA; 3: US Food and Drug Administration, Laurel, Maryland, USA; Issue Info: Dec2007, Vol. 13 Issue 12, p1932; Thesaurus Term: Salmonella; Thesaurus Term: Enterobacteriaceae; Subject Term: Salmonella enteritidis; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Endonucleases; Subject Term: Enzymes; Number of Pages: 4p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bendre, Sachin V.
AU - Shaddock, Joseph G.
AU - Dobrovolsky, Vasily N.
AU - Albertini, Richard J.
AU - Heflich, Robert H.
T1 - Effect of Chronic Azathioprine Treatment on Germ-Line Transmission of Hprt Mutation in Mice.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2007/12//
VL - 48
IS - 9
M3 - Article
SP - 744
EP - 753
SN - 08936692
AB - The article investigates the significance of prodrug of 6-mercaptopurine, Azathioprine (Aza) in the prevention of transplant rejection and treatment of autoimmune diseases in human. The inquiry was done by giving 55 male mice with 10 milligram/kilogram Aza thrice a week for 24 weeks, in which 10 control mice were treated with the vehicle. They were then bred to unexposed female mice for a range of 8 weeks. Examination of the Aza-treated male mice after the breeding period showed that 12 of them have higher hypoxanthine guanine phospho ribosyltransferase (HPRT) lymphocyte mutant frequencies. Such discovery reportedly manifests that Aza treatment successfully selected somatic cell mutants and there is no proof that long-term Aza treatment promotes high levels of germ-line Hprt mutation.
KW - Somatic cells
KW - Germ cells
KW - Mutagenesis
KW - Biochemical genetics
KW - Mice as laboratory animals
KW - Graft rejection -- Prevention
KW - Transplantation immunology
KW - Autoimmune diseases -- Treatment
KW - Lesch-Nyhan syndrome
KW - Lymphocytes
KW - germ cell mutation
KW - lymphocytes
KW - mutant selection
N1 - Accession Number: 28449208; Bendre, Sachin V. 1,2,3; Shaddock, Joseph G. 1; Dobrovolsky, Vasily N. 1; Albertini, Richard J. 4; Heflich, Robert H. 1,2; Email Address: robert.heflich@fda.hhs.gov; Affiliations: 1: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas; 2: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas; 3: Baylor College of Medicine, Department of Pediatrics, Division of Endocrinology and Metabolism, Houston, Texas; 4: University of Vermont, Burlington, Vermont; Issue Info: Dec2007, Vol. 48 Issue 9, p744; Thesaurus Term: Somatic cells; Thesaurus Term: Germ cells; Subject Term: Mutagenesis; Subject Term: Biochemical genetics; Subject Term: Mice as laboratory animals; Subject Term: Graft rejection -- Prevention; Subject Term: Transplantation immunology; Subject Term: Autoimmune diseases -- Treatment; Subject Term: Lesch-Nyhan syndrome; Subject Term: Lymphocytes; Author-Supplied Keyword: germ cell mutation; Author-Supplied Keyword: lymphocytes; Author-Supplied Keyword: mutant selection; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1002/em.20352
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Von Eschenbach, Andrew C.
T1 - FDA's New Approach to Food Protection.
JO - Food Technology
JF - Food Technology
Y1 - 2007/12//
VL - 61
IS - 12
M3 - Article
SP - 116
EP - 116
SN - 00156639
AB - This article focuses on the approach of the U.S. Food and Drug Administration to the issue of food protection. Several factors considered for the call to new approach include new food sources, advances in production and distribution methods, and the increasing volume of imports due to consumer demand. The three elements of protection include the prevention of foodborne contamination, intervention at critical points in the food supply chain and rapid response to minimize harm.
KW - FOOD -- Safety measures
KW - FOOD industry
KW - FOODBORNE diseases
KW - FOOD supply
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 28125390; Von Eschenbach, Andrew C. 1; Affiliation: 1: Commissioner of Food and Drugs, Food and Drug Administration, 5600 Fisher's Ln., Rockville, MD 20857; Source Info: Dec2007, Vol. 61 Issue 12, p116; Subject Term: FOOD -- Safety measures; Subject Term: FOOD industry; Subject Term: FOODBORNE diseases; Subject Term: FOOD supply; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, J. L.
AU - Spitz, H. B.
AU - Yiin, J. H.
T1 - CHARACTERIZATION OF INTERNAL EXPOSURE TO ENRICHED URANIUM AT A FORMER GASEOUS DIFFUSION PLANT.
JO - Health Physics
JF - Health Physics
Y1 - 2007/12//
VL - 93
IS - 6
M3 - Article
SP - 636
EP - 644
SN - 00179078
AB - The article discusses a study conducted by the National Institute for Occupational Safety and Health (NIOSH) that measured myeloma in workers from the Oak Ridge K-25 gaseous diffusion plant due to exposure to internally-deposited uranium. The K-25 plant was used for uranium enrichment for nuclear weapons during World War II. Research into work procedures suggested the potential for inhaling of enriched uranium by workers. Lower maximum permissible concentration in air (MPCa) standards for uranium were established following research indicating the toxicity of uranium to the liver. Urine samples had been procured and urinalysis conducted using fluorometry and alpha particle counting. Fewer than twenty percent of workers were monitored for internal radiation exposure.
KW - Radiation exposure
KW - Uranium enrichment
KW - Alpha rays
KW - Gaseous diffusion plants
KW - Urinalysis
KW - Fluorimetry
KW - bioassay
KW - exposure, internal
KW - exposure, occupational
KW - uranium
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 27535535; Anderson, J. L. 1; Email Address: JLAnderson@cdc.gov; Spitz, H. B. 1; Yiin, J. H. 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), 4676 Columbia Parkway, Mail Stop R-44, Cincinnati, OH 45226; Issue Info: Dec2007, Vol. 93 Issue 6, p636; Thesaurus Term: Radiation exposure; Thesaurus Term: Uranium enrichment; Thesaurus Term: Alpha rays; Subject Term: Gaseous diffusion plants; Subject Term: Urinalysis; Subject Term: Fluorimetry; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: exposure, internal; Author-Supplied Keyword: exposure, occupational; Author-Supplied Keyword: uranium ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Balakumar, Pitchai
AU - Murthy, Sreekant
AU - Jagadeesh, Gowraganahalli
T1 - The basic concepts of scientific research and communication.
JO - Indian Journal of Pharmacology
JF - Indian Journal of Pharmacology
Y1 - 2007/12//
VL - 39
IS - 6
M3 - Proceeding
SP - 303
EP - 306
SN - 02537613
AB - Information on the Preconference Workshop held in conjunction with the 40th annual conference of the Indian Pharmacological Society held at the National Institute of Pharmaceutical Education and Research (NIPER) in Mohali, Punjab, India on November 1-3, 2007 is presented. The conference focused on trends in discovery and development of drugs. There were six sessions in all with 15 presentations made by distinguished speakers, including Dr. Sreekant Murthy, G. Jagadeesh, and R.M. Pandey.
KW - CONFERENCES & conventions
KW - DRUG development
KW - DISCOVERIES in science
KW - PHARMACOLOGY
KW - CONGRESSES
KW - PUNJAB (India)
KW - INDIA
N1 - Accession Number: 31130642; Balakumar, Pitchai 1; Email Address: pbala2006@gmail.com Murthy, Sreekant 2 Jagadeesh, Gowraganahalli 3; Affiliation: 1: Department of Pharmacology, ISF College of Pharmacy, Moga - 142 001, Punjab, India 2: Drexel University College of Medicine, Drexel University, Philadelphia, PA 19102, USA 3: Division of Cardiovascular and Renal Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA; Source Info: Dec2007, Vol. 39 Issue 6, p303; Subject Term: CONFERENCES & conventions; Subject Term: DRUG development; Subject Term: DISCOVERIES in science; Subject Term: PHARMACOLOGY; Subject Term: CONGRESSES; Subject Term: PUNJAB (India); Subject Term: INDIA; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 4p; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hill, Steven C.
T1 - The Accuracy of Reported Insurance Status in the MEPS.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2007///Winter2007
VL - 44
IS - 4
M3 - Article
SP - 443
EP - 468
SN - 00469580
AB - Estimates of the number of insured and uninsured Americans are watched by numerous policymakers and the public, yet studies find respondents do not report their insurance status perfectly. Using four sources of validation data, including surveys of employers and providers, this paper assesses the quality of respondents' reports of private insurance and uninsurance in the Medical Expenditure Panel Survey Household Component (MEPS-HC), a nationally representative household survey. Regression analysis is used to assess the extent to which factors are associated with disagreements in reported insurance status across sources. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - MEDICALLY uninsured persons
KW - REGRESSION analysis
KW - PUBLIC welfare
KW - MEDICAL care
KW - PUBLIC health
N1 - Accession Number: 30037432; Hill, Steven C. 1; Email Address: shill@arhq.gov; Affiliations: 1: Senior economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ); Issue Info: Winter2007, Vol. 44 Issue 4, p443; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICALLY uninsured persons; Thesaurus Term: REGRESSION analysis; Thesaurus Term: PUBLIC welfare; Thesaurus Term: MEDICAL care; Subject Term: PUBLIC health; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 26p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105744548
T1 - The accuracy of reported insurance status in the MEPS.
AU - Hill SC
Y1 - 2007///Winter2007
N1 - Accession Number: 105744548. Language: English. Entry Date: 20080620. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Instrument Validation
KW - Insurance, Health
KW - Medically Uninsured
KW - Descriptive Statistics
KW - Regression
KW - Secondary Analysis
KW - Surveys
KW - United States
KW - Validation Studies
KW - Human
SP - 443
EP - 468
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 44
IS - 4
PB - Sage Publications Inc.
AB - Estimates of the number of insured and uninsured Americans are watched by numerous policymakers and the public, yet studies find respondents do not report their insurance status perfectly. Using four sources of validation data, including surveys of employers and providers, this paper assesses the quality of respondents' reports of private insurance and uninsurance in the Medical Expenditure Panel Survey Household Component (MEPS-HC), a nationally representative household survey. Regression analysis is used to assess the extent to which factors are associated with disagreements in reported insurance status across sources.
SN - 0046-9580
AD - Center for Financing, Access and Cost Trends, AHRQ, 540 Gaither Road, Rockville, MD 20850; shill@ahrq.gov
U2 - PMID: 18338518.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wishart, H. D.
AU - Reeve, A. M. F.
AU - Grant, C. C.
T1 - Vitamin D deficiency in a multinational refugee population.
JO - Internal Medicine Journal
JF - Internal Medicine Journal
Y1 - 2007/12//
VL - 37
IS - 12
M3 - Article
SP - 792
EP - 797
PB - Wiley-Blackwell
SN - 14440903
AB - Background: Populations with increased skin pigmentation who have migrated to countries of high latitude are at increased risk of low vitamin D. This study aimed to determine the prevalence of low vitamin D among the refugee population arriving in New Zealand. Methods: An audit of all refugees arriving at the national refugee resettlement centre from May 2004 to May 2005 was carried out. Serum 25-hydroxyvitamin D3 levels were measured and defined as normal (50–150 nmol/L) or low, with low subdivided into insufficient (25 to <50 nmol/L) and deficient (<25 nmol/L). Whether vitamin D status varied with age and sex was determined. Results: Vitamin D was measured in 869 (99%) of the refugees and was low in 470 (54%, 95% confidence interval (CI) 51–57%). It was insufficient in 323 (37%, 95%CI 34–41%) and deficient in 147 (17%, 95%CI 15–20%). Female sex was associated with at least a 10 times increased risk of vitamin D deficiency (relative ratio 13.93, 95%CI 10.15–17.96). Women aged between 17 and 45 years and men aged 46 years and more were at greatest risk. Conclusion: Poor vitamin D status is prevalent among refugees arriving in New Zealand. Women, particularly those of child-bearing age are at greatest risk. Screening and ongoing surveillance for vitamin D deficiency should be considered for all recent refugee immigrants to New Zealand. [ABSTRACT FROM AUTHOR]
AB - Copyright of Internal Medicine Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITAMIN D deficiency
KW - HUMAN skin color
KW - REFUGEES
KW - SERUM
KW - NEW Zealand
KW - ethnic group
KW - New Zealand
KW - refugee
KW - sex
KW - vitamin D
N1 - Accession Number: 27525036; Wishart, H. D. 1 Reeve, A. M. F. 1 Grant, C. C. 2,3; Email Address: cc.grant@auckland.ac.nz; Affiliation: 1: Auckland Regional Public Health Service Medical Clinic, Mangere Refugee Resettlement Centre, Manakau City 2: Department of Paediatrics, University of Auckland 3: General Paediatrics, Starship Children's Hospital, Auckland District Health Board, Auckland, New Zealand; Source Info: Dec2007, Vol. 37 Issue 12, p792; Subject Term: VITAMIN D deficiency; Subject Term: HUMAN skin color; Subject Term: REFUGEES; Subject Term: SERUM; Subject Term: NEW Zealand; Author-Supplied Keyword: ethnic group; Author-Supplied Keyword: New Zealand; Author-Supplied Keyword: refugee; Author-Supplied Keyword: sex; Author-Supplied Keyword: vitamin D; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1445-5994.2007.01385.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105846391
T1 - Vitamin D deficiency in a multinational refugee population.
AU - Wishart HD
AU - Reeve AMF
AU - Grant CC
Y1 - 2007/12//
N1 - Accession Number: 105846391. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Australia & New Zealand; Biomedical; Peer Reviewed. NLM UID: 101092952.
KW - Refugees
KW - Skin Pigmentation -- Physiology
KW - Vitamin D Deficiency -- Ethnology
KW - Adolescence
KW - Adult
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Age
KW - New Zealand -- Ethnology
KW - Prevalence
KW - Vitamin D -- Blood
KW - Human
SP - 792
EP - 797
JO - Internal Medicine Journal
JF - Internal Medicine Journal
JA - INTERN MED J
VL - 37
IS - 12
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1444-0903
AD - Auckland Regional Public Health Service Medical Clinic, Mangere Refugee Resettlement Centre, Manakau City
U2 - PMID: 17517080.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bhattacharya, Amit
AU - Watts, Nelson B.
AU - Gordon, Jessica
AU - Shukla, Rakesh
AU - Waters, Thomas
AU - Bartels, Steve
AU - Coleman, Robert
T1 - Bone Quantity and Quality of Youths Working on a Farm--A Pilot Study.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2007/12//
VL - 12
IS - 4
M3 - Article
SP - 27
EP - 38
SN - 1059924X
AB - This study investigated the effect of farm-related activities on the bone health of youths. Bone quantity and bone quality were quantitated in 36 adolescents—18 youth with a history of working on farms and 18 youth not involved in farm-related activities. Bone quantity as depicted by bone mineral density (BMD) was measured with dual-energy x-ray absorptiometry. Bone quality was characterized with biomechanical measures based on bone geometry and measures of dynamic bone shock absorption (BSA) properties. Dynamic bone response measures provide preliminary evidence that farm-related physically demanding tasks lead to changes that may predispose the teenagers to degenerative skeletal disorders later in life. Future studies with larger samples need to be carried out to further support the findings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FARMERS
KW - YOUTH -- Health
KW - BONE density
KW - HUMAN body composition
KW - BONE growth
KW - QUALITY of work life
KW - WORK environment
KW - ABSORPTIOMETER
KW - RADIOSCOPIC diagnosis
KW - bone mass
KW - Bone quality
KW - bone shock absorption capacity
KW - farm youth
N1 - Accession Number: 35272326; Bhattacharya, Amit 1; Email Address: bhattaat@uc.edu Watts, Nelson B. 2 Gordon, Jessica 1 Shukla, Rakesh 3 Waters, Thomas 4 Bartels, Steve 5 Coleman, Robert 6; Affiliation: 1: Biomechanics Ergonomics Research Labs, Department of Environmental Health, University of Cincinnati College of Medicine 2: University of Cincinnati Bone Health and Osteoporosis Center, Endocrinology Division, Department of Internal Medicine 3: Central Biostatistical Services, Department of Environmental Health, University of Cincinnati College of Medicine 4: Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio 5: Ohio State University Extension, Butler County 6: SignaLysis, Co, Cincinnati, Ohio; Source Info: 2007, Vol. 12 Issue 4, p27; Subject Term: FARMERS; Subject Term: YOUTH -- Health; Subject Term: BONE density; Subject Term: HUMAN body composition; Subject Term: BONE growth; Subject Term: QUALITY of work life; Subject Term: WORK environment; Subject Term: ABSORPTIOMETER; Subject Term: RADIOSCOPIC diagnosis; Author-Supplied Keyword: bone mass; Author-Supplied Keyword: Bone quality; Author-Supplied Keyword: bone shock absorption capacity; Author-Supplied Keyword: farm youth; Number of Pages: 12p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/10599240801985589
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Min Qi Wang
AU - Matthew, Resa F.
AU - Yu-Wen Chiu
AU - Bellamy, Nikki D.
T1 - Latent Model Analysis of Substance Use and HIV Risk Behaviors Among High-risk Minority Adults.
JO - Journal of Alcohol & Drug Education
JF - Journal of Alcohol & Drug Education
Y1 - 2007/12//
VL - 51
IS - 4
M3 - Article
SP - 35
EP - 62
PB - American Alcohol & Drug Information Foundation
SN - 00901482
AB - Objectives: This study evaluated substance use and HIV risk profile using a latent model analysis based on ecological theory, inclusive of a risk and protective factor framework, in sexually active minority adults (N=1,056) who participated in a federally funded substance abuse and HIV prevention health initiative from 2002 to 2006. Methods: Data were collected locally from community-based organizations using a common baseline instrument that was administered within 30 days of program entry. The latent variables included were social support; neighborhood attachment; family cohesion; intimate abuse; alcohol, tobacco/other drugs (ATOD) use; and HIV risk behaviors. Results: The model-fit indices met acceptable standards for African Americans (CFI = 0.962, TLI = 0.956, RMSEA = 0.033) and for Hispanic/Latinos (CFI = 0.927, TLI = 0.917, RMSEA = 0.047). For African Americans, neighborhood attachment was significantly related to intimate abuse (coefficient =.126, p<.01) and family cohesion (coefficient = .281, p<.01). Social support was not significantly related to either family cohesion or intimate abuse. Family cohesion was negatively related to ATOD use. which was also related to sex with risk partners and drug-related sex. For Hispanics, neighborhood attachment was significantly related to intimate abuse (coefficient = .209, p<.01) and family cohesion (coefficient = .209, p<.01). Social support was significantly related to family cohesion (coefficient = .274, p<.01), but not related to intimate abuse, Intimate abuse was negatively related to A TOD use. Conclusions: The results support the inclusion of protective factors as a standard implementation approach for prevention programs targeted to the reduction of ATOD use and HIV risk among sexually active minority adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Alcohol & Drug Education is the property of American Alcohol & Drug Information Foundation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse
KW - MINORITIES
KW - HIV (Viruses)
KW - PREVENTION
KW - SOCIAL support
KW - ALCOHOLISM
KW - SOCIAL networks
N1 - Accession Number: 30037587; Min Qi Wang 1 Matthew, Resa F. 1 Yu-Wen Chiu 1 Bellamy, Nikki D. 2; Affiliation: 1: Community College of Rhode Island, Newport 2: Center for Substance Abuse Prevention; Source Info: Dec2007, Vol. 51 Issue 4, p35; Subject Term: SUBSTANCE abuse; Subject Term: MINORITIES; Subject Term: HIV (Viruses); Subject Term: PREVENTION; Subject Term: SOCIAL support; Subject Term: ALCOHOLISM; Subject Term: SOCIAL networks; NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 28p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sue-Jane Wang
T1 - Discussion of the "White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Designs".
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2007/12//
VL - 17
IS - 6
M3 - Article
SP - 1015
EP - 1020
PB - Taylor & Francis Ltd
SN - 10543406
AB - The article discusses the White Paper of adaptive dose-ranging study to address the early phase drug development issues through simulation methods. The author provides the evaluation metrics including the detection of dose-response (DR), identification of clinical outputs, selection of target dose and estimation of DR profile within the observed dose range.
KW - DOSAGE of drugs
KW - DRUG development
KW - DRUGS -- Dose-response relationship
KW - SIMULATION methods & models
KW - CLINICAL trials
KW - PHARMACOLOGY
N1 - Accession Number: 27529219; Sue-Jane Wang 1; Email Address: suejane.wang@fda.hhs.gov; Affiliation: 1: Center for Drug Evaluation and Research, US Food and Drug Administration, Maryland, USA; Source Info: Dec2007, Vol. 17 Issue 6, p1015; Subject Term: DOSAGE of drugs; Subject Term: DRUG development; Subject Term: DRUGS -- Dose-response relationship; Subject Term: SIMULATION methods & models; Subject Term: CLINICAL trials; Subject Term: PHARMACOLOGY; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/10543400701643897
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Himathongkham, Sunee
AU - Dodd, Mary Lee
AU - Yee, Jenny K.
AU - Lau, David K.
AU - Bryant, Raymond G.
AU - Badoiu, Alexandru S.
AU - Lau, Henry K.
AU - Guthertz, Linda S.
AU - Crawford-Miksza, Leta
AU - Soliman, Mary A.
T1 - Recirculating Immunomagnetic Separation and Optimal Enrichment Conditions for Enhanced Detection and Recovery of Low Levels of Escherichia coli O157:H7 from Fresh Leafy Produce and Surface Water.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/12//
VL - 70
IS - 12
M3 - Article
SP - 2717
EP - 2724
SN - 0362028X
AB - The objective of this study was to develop a rapid, simple method for enhanced detection and isolation of low levels of Escherichia coli O157:H7 from leafy produce and surface water using recirculating immunomagnetic separation (RIMS) coupled with real-time PCR and a standard culture method. The optimal enrichment conditions for the method also were determined. Analysis of real-time PCR data (Cr values) suggested that incubation of lettuce and spinach leaves rather than rinsates provides better enrichment of E. coli O157:H7. Enrichment of lettuce or spinach leaves at 42°C for 5 h provided better detection than enrichment at 37°C. Extended incubation of surface water for 20 h at 42°C did not improve the detection. The optimized enrichment conditions were also employed with modified Moore swabs, which were used to sample flowing water sites. Positive isolation rates and real-time PCR results indicated an increased recovery of E. coli O157:H7 from all samples following the application of RIMS. Under these conditions, the method provided detection and/or isolation of E. coli O157:H7 at levels as low as 0.07 CFU/g of lettuce, 0.1 CFU/g of spinach, 6 CFU/100 ml of surface water, and 9 CFU per modified Moore swab. During a 6-month field study, modified Moore swabs yielded high isolation rates when deployed in natural watershed sites. The method used in this study was effective for monitoring E. coli O157:H7 in the farm environment, during postharvest processing, and in foodborne outbreak investigations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Storm drains
KW - Foodborne diseases
KW - Postharvest diseases & injuries
KW - Escherichia coli
KW - Escherichia coli O157:H7
KW - Spinach -- Diseases & pests
N1 - Accession Number: 27952540; Himathongkham, Sunee 1; Email Address: sunee.himathongkham@cdph.ca.gov; Dodd, Mary Lee 1; Yee, Jenny K. 2; Lau, David K. 2; Bryant, Raymond G. 1; Badoiu, Alexandru S. 1; Lau, Henry K. 2; Guthertz, Linda S. 1; Crawford-Miksza, Leta 1; Soliman, Mary A. 1; Affiliations: 1: Food and Drug Laboratory Branch, California Department of Public Health, Richmond, California 94804; 2: U.S. Food and Drug Administration, San Francisco District Laboratory, Alameda, California 94502, USA; Issue Info: Dec2007, Vol. 70 Issue 12, p2717; Thesaurus Term: Storm drains; Thesaurus Term: Foodborne diseases; Thesaurus Term: Postharvest diseases & injuries; Thesaurus Term: Escherichia coli; Subject Term: Escherichia coli O157:H7; Subject Term: Spinach -- Diseases & pests; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gutiérrez, A. J.
AU - González-Weller, D.
AU - González, T.
AU - Burgos, A.
AU - Lozano, G.
AU - Reguera, J. I.
AU - Hardisson, A.
T1 - Content of Toxic Heavy Metals (Mercury, Lead, and Cadmium) in Canned Variegated Scallops (Chlamys varia).
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2007/12//
VL - 70
IS - 12
M3 - Article
SP - 2911
EP - 2915
SN - 0362028X
AB - The concentrations of three toxic heavy metals, mercury (Hg), lead (Pb), and cadmium (Cd), were determined in preserved variegated scallops (Chlamys varia, Bivalvia, Mollusca), which are often consumed in Tenerife (Canary Islands, Spain). A total of 300 samples of seven commercial brands (A, B, D, H, J, L, and M) and one processed product ("scallop sauce") were analyzed. Samples were collected weekly in a major shopping area in Santa Cruz de Tenerife during a 12-month period. The concentrations of lead and mercury were far below the maximum limit permitted for human consumption by the European Communities Commission regulation (EC) 466/2001 (1 and 0.5 mg kg-1 wet weight for Pb and Hg, respectively). Concentrations of cadmium were close to the maximum limit permitted by regulation (EC) 466/2001 (1 mg kg-1 wet weight). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Heavy metals
KW - Scallops
KW - Cadmium
KW - Mercury
KW - Lead
KW - Surface tension
N1 - Accession Number: 27952572; Gutiérrez, A. J. 1; González-Weller, D. 2; Email Address: dgonzal@ull.es; González, T. 3; Burgos, A. 4; Lozano, G. 5; Reguera, J. I. 6; Hardisson, A. 2; Affiliations: 1: Department of Toxicology and Animal Biology (Marine Sciences), University of La Laguna, 38206 La Laguna, Tenerife, Canary Islands, Spain; 2: Department of Toxicology, University of La Laguna, 38071 La Laguna, Tenerife, Canary Islands, Spain; 3: Canarian Public Health Service, 38006 Santa Cruz de Tenerife, Tenerife, Canary Islands, Spain; 4: Department of Preventive Medicine and Public Health, University of La Laguna, 38071 La Laguna, Tenerife, Canary Islands, Spain; 5: Department of Animal Biology (Marine Sciences), University of La Laguna, 38206 La Laguna, Tenerife, Canary Islands, Spain; 6: Department of Microbiology, Faculty of Food Science and Technology, University of Burgos, Misael Bañuelos, Burgos, 09001, Spain; Issue Info: Dec2007, Vol. 70 Issue 12, p2911; Thesaurus Term: Heavy metals; Thesaurus Term: Scallops; Thesaurus Term: Cadmium; Thesaurus Term: Mercury; Thesaurus Term: Lead; Thesaurus Term: Surface tension; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Smith, D. R.
AU - Leggat, P. A.
T1 - Prevalence and Distribution of Musculoskeletal Pain Among Australian Medical Students.
JO - Journal of Musculoskeletal Pain
JF - Journal of Musculoskeletal Pain
Y1 - 2007/12//
VL - 15
IS - 4
M3 - Article
SP - 39
EP - 46
SN - 10582452
AB - Objectives: Although musculoskeletal pain [MSP] represents an important issue for young people and adolescents, few studies have investigated these conditions among a cross-section of medical students. Methods: We conducted a questionnaire survey of MSP among 261 students from a medical school in tropical northern Australia during 2004. Results: We had a 97.3 percent response rate. The prevalence of MSP at any body site varied from 75.8 percent in the second-year students to 89.3 percent in the third-year students, most frequently occurring at the neck [52.8 percent], lower back [51.6 percent], and shoulders [46.5 percent]. When compared with males, female students were more likely to report MSP [3.4 times for neck pain, 2.5 times for upper back pain, 2.0 times for shoulder pain, and 1.8 times as for lower back pain]. Second-year medical students were only 0.4 times as likely to report MSP at either the neck, upper back, or any body site when compared to students in the other three grades. Conclusions: Overall, our study suggests that MSP affects Australian medical students at reasonably high rates, although the prevalence, distributions, and correlations for these conditions do not appear to be uniform. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Musculoskeletal Pain is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAIN
KW - MEDICAL students
KW - NECK pain
KW - SHOULDER pain
KW - BACKACHE
KW - AUSTRALIA, Northern
KW - Australia
KW - low back pain
KW - Medical student
KW - musculoskeletal pain
KW - prevalence
N1 - Accession Number: 27135354; Smith, D. R. 1,2; Email Address: smith@h.jniosh.go.jp Leggat, P. A. 3; Affiliation: 1: International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, Kawasaki, Japan 2: School of Public Health and Tropical Medicine. James-Cook University, Townsville, Australia 3: School of Public Health and Tropical Medicine, James Cook University, Townsville, Australia; Source Info: 2007, Vol. 15 Issue 4, p39; Subject Term: PAIN; Subject Term: MEDICAL students; Subject Term: NECK pain; Subject Term: SHOULDER pain; Subject Term: BACKACHE; Subject Term: AUSTRALIA, Northern; Author-Supplied Keyword: Australia; Author-Supplied Keyword: low back pain; Author-Supplied Keyword: Medical student; Author-Supplied Keyword: musculoskeletal pain; Author-Supplied Keyword: prevalence; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1300/J094v15n04_05
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27135354&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105871573
T1 - Prevalence and distribution of musculoskeletal pain among Australian medical students.
AU - Smith DR
AU - Leggat PA
Y1 - 2007/12//
N1 - Accession Number: 105871573. Language: English. Entry Date: 20080328. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pain and Pain Management. Instrumentation: Nordic Questionnaire. NLM UID: 9302330.
KW - Muscle Pain -- Epidemiology -- Queensland
KW - Students, Medical
KW - Adolescence
KW - Adult
KW - Chi Square Test
KW - Comparative Studies
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - Health Behavior
KW - Logistic Regression
KW - Male
KW - Mantel-Haenszel Test
KW - Odds Ratio
KW - Queensland
KW - Questionnaires
KW - Retrospective Design
KW - Schools, Medical
KW - Self Report
KW - Surveys
KW - Human
SP - 39
EP - 46
JO - Journal of Musculoskeletal Pain
JF - Journal of Musculoskeletal Pain
JA - J MUSCULOSKELETAL PAIN
VL - 15
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Objectives: Although musculoskeletal pain [MSP] represents an important issue for young people and adolescents, few studies have investigated these conditions among a cross-section of medical students. Methods: We conducted a questionnaire survey of MSP among 261 students from a medical school in tropical northern Australia during 2004. Results: We had a 97.3 percent response rate. The prevalence of MSP at any body site varied from 75.8 percent in the second-year students to 89.3 percent in the third-year students, most frequently occurring at the neck [52.8 percent], lower back [51.6 percent], and shoulders [46.5 percent]. When compared with males, female students were more likely to report MSP [3.4 times for neck pain, 2.5 times for upper back pain, 2.0 times for shoulder pain, and 1.8 times as for lower back pain]. Second-year medical students were only 0.4 times as likely to report MSP at either the neck, upper back, or any body site when compared to students in the other three grades. Conclusions: Overall, our study suggests that MSP affects Australian medical students at reasonably high rates, although the prevalence, distributions, and correlations for these conditions do not appear to be uniform.
SN - 1058-2452
AD - International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585 Japan
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105871573&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Methner, Mark M.
AU - Birch, M. Eileen
AU - Evans, Douglas E.
AU - Bon-Ki Ku
AU - Crouch, Keith
AU - Hoover, Mark D.
T1 - Case Study.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/12//
VL - 4
IS - 12
M3 - Article
SP - 125
EP - 130
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents a case study which examines operations involved in the processing of carbon nanofibers (CNF) materials and their emission. As reported, filter-based air and surface samples were collected near various processes to evaluate migration of carbonaceous nanomaterials within the facility. It was found that air concentrations within the laboratory processing area were 2 to 64 times those in a nearby office area.
KW - Emissions (Air pollution)
KW - Industrial hygiene
KW - Case studies
KW - Nanofibers
KW - Laboratories
KW - Nanostructured materials
N1 - Accession Number: 32092762; Methner, Mark M. 1; Birch, M. Eileen 1; Evans, Douglas E. 1; Bon-Ki Ku 1; Crouch, Keith 1; Hoover, Mark D. 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia.; Issue Info: Dec2007, Vol. 4 Issue 12, p125; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Industrial hygiene; Subject Term: Case studies; Subject Term: Nanofibers; Subject Term: Laboratories; Subject Term: Nanostructured materials; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620701683871
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092762&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, Arthur L.
AU - Hoover, Mark D.
AU - Mitchell, David M.
AU - Stapleton, Brian P.
T1 - Commentary.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/12//
VL - 4
IS - 12
M3 - Article
SP - 131
EP - 134
SN - 15459624
AB - The article presents information related to the Nanoparticle Information Library (NIL), an Internet-based prototype created by the National Institute for Occupational Safety and Health (NIOSH) for fostering information exchange and understanding nanoparticles and their properties. As reported, NIL aims at identifying and preventing potential adverse effects from nanoparticles by communicating information about health and safety issues that may be associated with nanoparticle manufacturing, handling, or exposure.
KW - ONLINE information services
KW - OVERSEAS information libraries
KW - INTERNET
KW - NANOPARTICLES
KW - NANOSTRUCTURED materials
KW - INDUSTRIAL safety
KW - INDUSTRIAL hygiene
KW - ENVIRONMENTAL health
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 32092774; Miller, Arthur L. 1 Hoover, Mark D. 2 Mitchell, David M. 3 Stapleton, Brian P. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Spokane, Washington. 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia. 3: Interactive Consulting, Spokane, Washington.; Source Info: Dec2007, Vol. 4 Issue 12, p131; Subject Term: ONLINE information services; Subject Term: OVERSEAS information libraries; Subject Term: INTERNET; Subject Term: NANOPARTICLES; Subject Term: NANOSTRUCTURED materials; Subject Term: INDUSTRIAL safety; Subject Term: INDUSTRIAL hygiene; Subject Term: ENVIRONMENTAL health; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 517110 Wired Telecommunications Carriers; NAICS/Industry Codes: 519130 Internet Publishing and Broadcasting and Web Search Portals; NAICS/Industry Codes: 519120 Libraries and Archives; Number of Pages: 4p; Illustrations: 1 Black and White Photograph; Document Type: Article
L3 - 10.1080/15459620701683947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32092774&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shaffer, Ronald E.
AU - Gao, Pengfei
AU - Gerald V. Coles
T1 - Letters to the Editor.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/12//
VL - 4
IS - 12
M3 - Article
SP - 135
EP - 135
PB - Taylor & Francis Ltd
SN - 15459624
AB - Two letters to the editor are presented in response to article in previous issues, including an article on chamber design requirements for ensemble testing, by Ronald E. Shaffer, and Pengfei Gao, and an article on the value of a protective ensemble that can be negated due to the effects of heat stress.
KW - Industrial hygiene
KW - Environmental health
KW - Letters to the editor
KW - Heat -- Physiological effect
KW - Work clothes
N1 - Accession Number: 32092767; Shaffer, Ronald E. 1; Gao, Pengfei 1; Gerald V. Coles 2; Affiliations: 1: National Personal Protective Technology Lab, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, Pa.; 2: Deakin University, Metung, Victoria, Australia.; Issue Info: Dec2007, Vol. 4 Issue 12, p135; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Subject Term: Letters to the editor; Subject Term: Heat -- Physiological effect; Subject Term: Work clothes; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 315249 Women's and girls' cut and sew clothing manufacturing; NAICS/Industry Codes: 315220 Men's and Boys' Cut and Sew Apparel Manufacturing; NAICS/Industry Codes: 812332 Industrial Launderers; NAICS/Industry Codes: 448199 All other clothing stores; Number of Pages: 1p; Document Type: Article
L3 - 10.1080/15459620701700758
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092767&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bartley, David L.
AU - Slaven, James E.
AU - Rose, Mike C.
AU - Andrew, Michael E.
AU - Harper, Martin
T1 - Uncertainty Determination for Nondestructive Chemical Analytical Methods Using Field Data and Application to XRF Analysis for Lead.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2007/12//
VL - 4
IS - 12
M3 - Article
SP - 931
EP - 942
PB - Taylor & Francis Ltd
SN - 15459624
AB - Air sampling and analytical methods are developed to provide a basis for decision making. They are evaluated in the laboratory against prescribed fitness-for-use criteria even though laboratory validation does not take into account all possible sources of uncertainty in field application. Field evaluation would be preferable but is complicated by the lack of controlled conditions, which limits the ability to compare analytical methods and to recognize outliers and assess variance homogeneity across the range of interest. The specific situation of evaluating nondestructive field analytical methods against their reference laboratory equivalent is considered here, since the difficulty of providing replicates is obviated in this case. A portable X-ray fluorescence (XRF) analyzer was used to determine the lead content of air filter samples from several workplaces where lead is used or is a contaminant of the process material. The portable XRF method has the advantage of allowing for faster decisions compared with the alternative of submitting the air samples to an off-site laboratory for analysis. Since the XRF method is nondestructive, the same air samples were also subjected to the reference laboratory-based method of analysis. Two statistical approaches were developed specifically to deal with non-normal elements of the data in evaluating the results. The ISO GUM method identifies outliers and then calculates an accuracy range about the true concentration for the remainder of the data. This coverage is then adjusted to account for the rate of outlier occurrence. The bootstrap procedure uses a large number of computer-generated data points that are sampled, with replacement, from the original set including outliers to determine the coverage. No significant difference is seen between the two statistical approaches. Both approaches result in similar coverage and support the adoption of method acceptance criteria specific to field evaluation (a symmetric accuracy range of 35%). The portable XRF analyzer met this criterion when used with several different sampling methods and thus could be used as a method for routine evaluation of compliance with lead limit values. As the method is nondestructive, further analysis of air samples with analytical results near decision points is possible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air analysis
KW - Meteorological instruments
KW - Dust control
KW - Spectrum analysis
KW - Air sampling apparatus
KW - X-ray spectroscopy
KW - Laboratories
KW - Homogeneity
KW - Sampling (Process)
KW - air sampling
KW - lead
KW - uncertainty
KW - X-ray fluorescence
N1 - Accession Number: 32092764; Bartley, David L. 1; Slaven, James E. 2; Rose, Mike C. 3; Andrew, Michael E. 2; Harper, Martin 4; Email Address: zzg7@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, Morgantown, West Virginia.; 3: Occupational Safety and Health Administration, Salt Lake Technical Center, Sandy, Utah.; 4: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Exposure Assessment Branch, Morgantown, West Virginia.; Issue Info: Dec2007, Vol. 4 Issue 12, p931; Thesaurus Term: Air analysis; Thesaurus Term: Meteorological instruments; Thesaurus Term: Dust control; Thesaurus Term: Spectrum analysis; Subject Term: Air sampling apparatus; Subject Term: X-ray spectroscopy; Subject Term: Laboratories; Subject Term: Homogeneity; Subject Term: Sampling (Process); Author-Supplied Keyword: air sampling; Author-Supplied Keyword: lead; Author-Supplied Keyword: uncertainty; Author-Supplied Keyword: X-ray fluorescence; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 12p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1080/15459620701712712
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092764&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105858359
T1 - Uncertainty determination for nondestructive chemical analytical methods using field data and application to XRF analysis for lead.
AU - Bartley DL
AU - Slaven JE
AU - Rose MC
AU - Andrew ME
AU - Harper M
Y1 - 2007/12//
N1 - Accession Number: 105858359. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Environmental Monitoring -- Equipment and Supplies
KW - Lead -- Analysis
KW - Occupational Exposure -- Analysis
KW - Spectrometry, X-Ray Emission -- Equipment and Supplies
KW - Confidence Intervals
KW - Environmental Monitoring -- Methods
KW - Metallurgy
KW - Occupational Exposure
KW - Sensitivity and Specificity
KW - Human
SP - 931
EP - 942
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Air sampling and analytical methods are developed to provide a basis for decision making. They are evaluated in the laboratory against prescribed fitness-for-use criteria even though laboratory validation does not take into account all possible sources of uncertainty in field application. Field evaluation would be preferable but is complicated by the lack of controlled conditions, which limits the ability to compare analytical methods and to recognize outliers and assess variance homogeneity across the range of interest. The specific situation of evaluating nondestructive field analytical methods against their reference laboratory equivalent is considered here, since the difficulty of providing replicates is obviated in this case. A portable X-ray fluorescence (XRF) analyzer was used to determine the lead content of air filter samples from several workplaces where lead is used or is a contaminant of the process material. The portable XRF method has the advantage of allowing for faster decisions compared with the alternative of submitting the air samples to an off-site laboratory for analysis. Since the XRF method is nondestructive, the same air samples were also subjected to the reference laboratory-based method of analysis. Two statistical approaches were developed specifically to deal with non-normal elements of the data in evaluating the results. The ISO GUM method identifies outliers and then calculates an accuracy range about the true concentration for the remainder of the data. This coverage is then adjusted to account for the rate of outlier occurrence. The bootstrap procedure uses a large number of computer-generated data points that are sampled, with replacement, from the original set including outliers to determine the coverage. No significant difference is seen between the two statistical approaches. Both approaches result in similar coverage and support the adoption of method acceptance criteria specific to field evaluation (a symmetric accuracy range of 35%). The portable XRF analyzer met this criterion when used with several different sampling methods and thus could be used as a method for routine evaluation of compliance with lead limit values. As the method is nondestructive, further analysis of air samples with analytical results near decision points is possible.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
U2 - PMID: 17957563.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105858359&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105858352
T1 - Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations.
AU - Methner MM
AU - Birch ME
AU - Evans DE
AU - Ku BK
AU - Crouch K
AU - Hoover MD
Y1 - 2007/12//
N1 - Accession Number: 105858352. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Carbon -- Analysis
KW - Metals -- Analysis
KW - Particulate Matter -- Analysis
KW - Environmental Exposure
KW - Industry
KW - Occupational Exposure -- Analysis
KW - Protective Clothing
KW - Risk Assessment
SP - D125
EP - 30
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
U2 - PMID: 17943583.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105858351
T1 - The Nanoparticle Information Library (NIL): a prototype for linking and sharing emerging data.
AU - Miller AL
AU - Hoover MD
AU - Mitchell DM
AU - Stapleton BP
Y1 - 2007/12//
N1 - Accession Number: 105858351. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Libraries
KW - Nanotechnology -- Adverse Effects
KW - Nanotechnology -- Statistics and Numerical Data
KW - National Institute for Occupational Safety and Health
KW - Communication
KW - Cooperative Behavior
KW - Data Collection
KW - Industry
KW - Information Retrieval
KW - Internet
KW - Resource Databases
KW - United States
KW - Human
SP - D131
EP - 4
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 4
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Spokane, WA, USA.
U2 - PMID: 17924276.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105858351&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hamad, Mazen L.
AU - Ellison, Christopher D.
AU - Khan, Mansoor A.
AU - Lyon, Robbe C.
T1 - Drug product characterization by Macropixel Analysis of chemical images.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/12//
VL - 96
IS - 12
M3 - Article
SP - 3390
EP - 3401
SN - 00223549
AB - Traditional monitoring of pharmaceutical manufacturing combines physical sampling and analytical methodologies (e.g. HPLC). Process analytical technology (PAT) can be implemented to collect real-time measurements, although successful monitoring requires that sampling be representative. The maximum spot size for a spectroscopic tool (e.g. near-infrared; Raman) should be equivalent to a single dosage size. A smaller spot size may provide a PAT tool that is sensitive to monitoring process changes, but if too small, produces non-reproducible data. The current study uses chemical imaging to determine appropriate spot size. A chemical image is an array of pixels which maps the chemical composition of the sample. “Macropixel Analysis” is introduced as a measure of image heterogeneity based on clusters of pixels (macropixels) within near-infrared chemical images. Analyses were conducted using non-overlapping tiles of macropixels (Discrete-Level Tiling) and all possible macropixels of the image (Continuous-Level Moving Block). Both methods minimize the variance between macropixel intensities by varying the size of the macropixels. Spot size is then chosen as the minimum macropixel size for which the range of macropixel intensities falls within an acceptable criterion. Both imaging-based algorithms provide useful quantitative information about the heterogeneity of pharmaceutical products. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3390–3401, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - DRUGS
KW - NEAR infrared spectroscopy
KW - MULTIVARIATE analysis
KW - IMAGE analysis
KW - IMAGING systems in chemistry
KW - algorithms
KW - chemical imaging
KW - heterogeneity
KW - heterogeneous systems
KW - image analysis
KW - imaging methods
KW - macropixels
KW - multivariate analysis
KW - near-infrared spectroscopy
KW - NIR imaging
N1 - Accession Number: 27296491; Hamad, Mazen L. 1 Ellison, Christopher D. 1 Khan, Mansoor A. 1 Lyon, Robbe C. 1; Email Address: Robbe.Lyon@FDA.HHS.gov; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Dec2007, Vol. 96 Issue 12, p3390; Subject Term: PHARMACEUTICAL industry; Subject Term: DRUGS; Subject Term: NEAR infrared spectroscopy; Subject Term: MULTIVARIATE analysis; Subject Term: IMAGE analysis; Subject Term: IMAGING systems in chemistry; Author-Supplied Keyword: algorithms; Author-Supplied Keyword: chemical imaging; Author-Supplied Keyword: heterogeneity; Author-Supplied Keyword: heterogeneous systems; Author-Supplied Keyword: image analysis; Author-Supplied Keyword: imaging methods; Author-Supplied Keyword: macropixels; Author-Supplied Keyword: multivariate analysis; Author-Supplied Keyword: near-infrared spectroscopy; Author-Supplied Keyword: NIR imaging; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 12p; Illustrations: 1 Diagram, 2 Charts, 9 Graphs; Document Type: Article
L3 - 10.1002/jps.20971
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Minton, Allen P.
T1 - The effective hard particle model provides a simple, robust, and broadly applicable description of nonideal behavior in concentrated solutions of bovine serum albumin and other nonassociating proteins.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2007/12//
VL - 96
IS - 12
M3 - Article
SP - 3466
EP - 3469
SN - 00223549
AB - Published data on the concentration dependence of osmotic pressure of solutions of bovine serum albumin in 0.15 M NaCl at concentrations up to greater than 400 g/L are shown to be described to within experimental uncertainty by a simple one-parameter model in which protein molecules are represented by effective hard spherical particles. The volume of the effective hard particle reflects both steric and electrostatic repulsion and thus varies with pH and ionic strength. The pH dependence of the effective volume is shown to agree well with that previously obtained from analysis of the concentration dependence of sedimentation equilibrium and static light scattering. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 3466–3469, 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SERUM albumin
KW - PROTEIN-protein interactions
KW - LIGHT -- Scattering
KW - HYDROGEN-ion concentration
KW - ACIDITY function
KW - SEDIMENTATION analysis
KW - excluded volume
KW - light scattering
KW - osmotic pressure
KW - protein–protein interaction
KW - protein-protein interaction
KW - sedimentation equilibrium
N1 - Accession Number: 27296494; Minton, Allen P. 1; Email Address: minton@helix.nih.gov; Affiliation: 1: Section on Physical Biochemistry, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, Building 8, Room 226, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892-0830; Source Info: Dec2007, Vol. 96 Issue 12, p3466; Subject Term: SERUM albumin; Subject Term: PROTEIN-protein interactions; Subject Term: LIGHT -- Scattering; Subject Term: HYDROGEN-ion concentration; Subject Term: ACIDITY function; Subject Term: SEDIMENTATION analysis; Author-Supplied Keyword: excluded volume; Author-Supplied Keyword: light scattering; Author-Supplied Keyword: osmotic pressure; Author-Supplied Keyword: protein–protein interaction; Author-Supplied Keyword: protein-protein interaction; Author-Supplied Keyword: sedimentation equilibrium; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1002/jps.20964
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Porter, Dale W.
AU - Wolfarth, Michael
AU - Shih-Houng Young
AU - Rao, Murali K.
AU - Meighan, Terence
AU - Barger, Mark
AU - Andrew, Michael E.
AU - Huffman, Linda J.
T1 - PGJ2 Inhibition of LPS-induced Inflammatory Mediator Expression from Rat Alveolar Macrophages.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/12//
VL - 70
IS - 23
M3 - Article
SP - 1967
EP - 1976
SN - 15287394
AB - Studies suggested that 15-deoxy-Δ-12,14-prostaglandin J2 (PGJ2) may exert anti-inflammatory effects, including in the lung. Thus, in vitro studies were conducted to (1) investigate whether PGJ2 inhibited the production of inflammatory mediators from lipopolysaccharide (LPS)-exposed primary rat alveolar macrophages (AM), and (2) investigate possible mechanisms underlying PGJ2-mediated inhibition of inflammatory mediator production. These studies determined that PGJ2 inhibited LPS-induced nitric oxide (NO) production in a concentration- and time-dependent manner. PGJ2-mediated inhibition of NO, as well as of tumor necrosis factor-α (TNF-α) and macrophage inflammatory protein-2 (MIP-2), was also determined to be dependent on the time of addition of PGJ2 relative to LPS, and suggested the PGJ2 inhibitory mechanism is an early event. PGJ2 was shown not to interfere with binding or internalization of LPS by AM, indicating this was not responsible for PGJ2 inhibitory effects. Another possible mechanism underlying PGJ2-mediated inhibition was via peroxisome proliferator-activated receptor-γ (PPAR-γ). However, biochemical studies suggested that PGJ2-mediated inhibition was not occurring through PPAR-γ dependent mechanism, and molecular studies further established that both LPS and PGJ2 decrease PPAR-γ mRNA expression. A third possible mechanism underlying PGJ2-mediated inhibition was by alteration of nuclear factor (NF)-κB. Molecular studies confirmed that LPS stimulated NF-κB mRNA expression, and PGJ2 reduced this stimulation, which is consistent with PGJ2 effect on LPS-induced production of NO, TNF-α and MIP-2. Thus, data in this study established that PGJ2 inhibited LPS-induced inflammatory mediator production in rat AM, and this inhibition is mediated, at least in part, by reducing the expression of NF-κB mRNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTAGLANDINS
KW - ANTI-inflammatory agents
KW - MACROPHAGES
KW - LUNGS
KW - RATS
KW - INFLAMMATION -- Mediators
KW - ENDOTOXINS
KW - NITRIC oxide
KW - TUMOR necrosis factor
KW - PEROXISOMES
KW - MESSENGER RNA
N1 - Accession Number: 27240710; Porter, Dale W. 1,2; Email Address: dporter@cdc.gov Wolfarth, Michael 1 Shih-Houng Young 1 Rao, Murali K. 1 Meighan, Terence 1 Barger, Mark 1 Andrew, Michael E. 1 Huffman, Linda J. 1,2; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA 2: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia, USA; Source Info: Dec2007, Vol. 70 Issue 23, p1967; Subject Term: PROSTAGLANDINS; Subject Term: ANTI-inflammatory agents; Subject Term: MACROPHAGES; Subject Term: LUNGS; Subject Term: RATS; Subject Term: INFLAMMATION -- Mediators; Subject Term: ENDOTOXINS; Subject Term: NITRIC oxide; Subject Term: TUMOR necrosis factor; Subject Term: PEROXISOMES; Subject Term: MESSENGER RNA; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 1 Chart, 9 Graphs; Document Type: Article
L3 - 10.1080/15287390701549260
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Deiman, B.
AU - Schrover, C.
AU - Moore, C.
AU - Westmoreland, D.
AU - van de Wiel, P.
T1 - Rapid and highly sensitive qualitative real-time assay for detection of respiratory syncytial virus A and B using NASBA and molecular beacon technology
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2007/12//
VL - 146
IS - 1/2
M3 - Article
SP - 29
EP - 35
SN - 01660934
AB - Abstract: The performance of a sensitive and specific qualitative respiratory syncytial virus (RSV) assay based on NASBA technology and real-time molecular beacon detection is presented. Very low detection limits for both RSV A and RSV B were determined: 95% detection hit-rate of 95 and 47 copies/input in isolation for RSV A and RSV B, respectively. RSV was detected in a wide variety of clinical samples including respiratory swabs, nasopharyngeal aspirates (NPA), bronchoalveolar lavages (BAL), endotracheal secretions, and sputum samples. In total 779 clinical samples were tested and a valid result was obtained for 765 (RSV NASBA assay), 765 (cell culture), and 529 (rapid direct immunofluorescence testing (IF)) samples. Of these samples, 229 (RSV NASBA assay), 61 (cell culture), and 122 (IF) samples were positive for RSV. In addition, 106 samples were reported as RSV negative using the NOW® RSV assay (Binax). Subsequent testing using the RSV NASBA assay demonstrated that 32 (30%) of these samples were RSV positive. The RSV NASBA assay includes a homologous internal control, which offers a high degree of standardization and quality control. When the RSV NASBA assay was performed on the NucliSens EasyQ platform (bioMérieux), test results of 48 sample extracts were obtained in less than 2h. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - MICROBIOLOGICAL assay
KW - ISOLATION of viruses
KW - IMMUNOCYTOCHEMISTRY
KW - Amplification
KW - Detection
KW - NASBA
KW - Real-time
KW - Respiratory
KW - RSV
N1 - Accession Number: 27353130; Deiman, B. 1; Email Address: birgit.deiman@eu.biomerieux.com Schrover, C. 1 Moore, C. 2 Westmoreland, D. 2 van de Wiel, P. 1; Affiliation: 1: BioMerieux bv, Boseind 15, P.O. Box 84, 5280 AB Boxtel and Wales Specialist Virology Centre, Netherlands 2: National Public Health Service for Wales Microbiology Cardiff, University Hospital of Wales, Health Park, Cardiff, CF, 14 4XW, UK; Source Info: Dec2007, Vol. 146 Issue 1/2, p29; Subject Term: RESPIRATORY syncytial virus; Subject Term: MICROBIOLOGICAL assay; Subject Term: ISOLATION of viruses; Subject Term: IMMUNOCYTOCHEMISTRY; Author-Supplied Keyword: Amplification; Author-Supplied Keyword: Detection; Author-Supplied Keyword: NASBA; Author-Supplied Keyword: Real-time; Author-Supplied Keyword: Respiratory; Author-Supplied Keyword: RSV; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2007.05.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wildiers, Hans
AU - Kunkler, Ian
AU - Biganzoli, Laura
AU - Fracheboud, Jacques
AU - Vlastos, George
AU - Bernard-Marty, Chantal
AU - Hurria, Arti
AU - Extermann, Martine
AU - Girre, Véronique
AU - Brain, Etienne
AU - Audisio, Riccardo A
AU - Bartelink, Harry
AU - Barton, Mary
AU - Giordano, Sharon H
AU - Muss, Hyman
AU - Aapro, Matti
T1 - Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology
JO - Lancet Oncology
JF - Lancet Oncology
Y1 - 2007/12//
VL - 8
IS - 12
M3 - Article
SP - 1101
EP - 1115
SN - 14702045
AB - Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in women worldwide. Elderly individuals make up a large part of the breast cancer population, and there are important specific considerations for this population. The International Society of Geriatric Oncology created a task force to assess the available evidence on breast cancer in elderly individuals, and to provide evidence-based recommendations for the diagnosis and treatment of breast cancer in such individuals. A review of the published work was done with the results of a search on Medline for English-language articles published between 1990 and 2007 and of abstracts from key international conferences. Recommendations are given on the topics of screening, surgery, radiotherapy, (neo)adjuvant hormone treatment and chemotherapy, and metastatic disease. Since large randomised trials in elderly patients with breast cancer are scarce, there is little level I evidence for the treatment of such patients. The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults. [Copyright &y& Elsevier]
AB - Copyright of Lancet Oncology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - GERIATRIC oncology
KW - OLDER people -- Diseases
KW - CANCER treatment
KW - IMMUNOLOGICAL adjuvants
N1 - Accession Number: 27724173; Wildiers, Hans 1; Email Address: hans.wildiers@uzleuven.be Kunkler, Ian 2 Biganzoli, Laura 3 Fracheboud, Jacques 4 Vlastos, George 5 Bernard-Marty, Chantal 6 Hurria, Arti 7 Extermann, Martine 8 Girre, Véronique 9 Brain, Etienne 10 Audisio, Riccardo A 11 Bartelink, Harry 12 Barton, Mary 13 Giordano, Sharon H 14 Muss, Hyman 15 Aapro, Matti 16; Affiliation: 1: Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium 2: Edinburgh Cancer Centre, University of Edinburgh, Edinburgh, UK 3: Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy 4: Department of Public Health, Erasmus University Medical Centre, Rotterdam, Netherlands 5: Senology and Surgical Gynecologic Unit, Geneva University Hospitals, Geneva, Switzerland 6: Medical Oncology Clinic, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium 7: Division of Medical Oncology and Experimental Therapeutics, City of Hope, Duarte, CA, USA 8: H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA 9: Department of Medical Oncology, Institut Curie, Paris, France 10: Medical Oncology, René Huguenin Cancer Centre, Saint-Cloud, France 11: University of Liverpool, Whiston Hospital, Prescot, UK 12: Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, Netherlands 13: Agency for Healthcare Research and Quality, Rockville, MD, USA 14: Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA 15: Hematology Oncology Unit, University of Vermont and Vermont Cancer Center, Burlington, VT, USA 16: Institut Multidisciplinaire d'Oncologie, Clinique de Genolier, Genolier, Switzerland; Source Info: Dec2007, Vol. 8 Issue 12, p1101; Subject Term: BREAST cancer; Subject Term: GERIATRIC oncology; Subject Term: OLDER people -- Diseases; Subject Term: CANCER treatment; Subject Term: IMMUNOLOGICAL adjuvants; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/S1470-2045(07)70378-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pavletic, S. Z.
AU - Zhou, G.
AU - Sobocinski, K.
AU - Marti, G.
AU - Doney, K.
AU - DiPersio, J.
AU - Feremans, W.
AU - Foroni, L.
AU - Goodman, S.
AU - Prentice, G.
AU - LeMaistre, C.
AU - Bandini, G.
AU - Ferrant, A.
AU - Jacobsen, N.
AU - Khouri, I.
AU - Gale, R. P.
AU - Wiestner, A.
AU - Giralt, S.
AU - Montserrat, E.
AU - Chan, W. C.
T1 - Genetically identical twin transplantation for chronic lymphocytic leukemia.
JO - Leukemia (08876924)
JF - Leukemia (08876924)
Y1 - 2007/12//
VL - 21
IS - 12
M3 - Article
SP - 2452
EP - 2455
PB - Nature Publishing Group
SN - 08876924
AB - We identified 19 persons with B-cell chronic lymphocytic leukemia (CLL) who received genetically identical twin blood cell or bone marrow transplants after high-dose conditioning. Ten are alive (eight disease-free) with a median follow-up of 89 months (range, 31–171 months); 5-year relapse rate was 50% (95% confidence interval (CI), 26–73%). Estimated 5-year survival and disease-free survival were 61% (95% CI, 37–82%) and 45% (95% CI, 23–68%). In two of four patients tested at 12 and 21 months by polymerase chain reaction no evidence of residual CLL was detected post-transplant. In one recipient who relapsed at 6 years, molecular studies showed a different CLL clone from that detected pretransplant. This clone was subsequently identified in the donor suggesting transfer of occult leukemia at the time of transplant. Genetically identical twin transplants can result in long-term disease-free survival and molecular remissions, these data suggest the potential for CLL control in the absence of allogeneic graft-versus-leukemia effect. The case of leukemia transfer indicates the need for careful evaluation of donors prior to graft collection.Leukemia (2007) 21, 2452–2455; doi:10.1038/sj.leu.2404928; published online 30 August 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Leukemia (08876924) is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC lymphocytic leukemia
KW - CHRONIC diseases
KW - LEUKEMIA
KW - TRANSPLANTATION of organs, tissues, etc.
KW - SURGERY
KW - CLL
KW - hematopoietic stem cell transplantation
KW - identical twin
N1 - Accession Number: 27561577; Pavletic, S. Z. 1; Email Address: pavletis@mail.nih.gov Zhou, G. 2 Sobocinski, K. 3 Marti, G. 4 Doney, K. 5 DiPersio, J. 6 Feremans, W. 7 Foroni, L. 8 Goodman, S. 9 Prentice, G. 8 LeMaistre, C. 10 Bandini, G. 11 Ferrant, A. 12 Jacobsen, N. 13 Khouri, I. 14 Gale, R. P. 3 Wiestner, A. 15 Giralt, S. 14 Montserrat, E. 16 Chan, W. C. 2; Affiliation: 1: National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA 2: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA 3: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA 4: Division of Cell and Gene Therapies, United States Food and Drug Administration, CBER, Bethesda, MD, USA 5: Department of Medicine, University of Washington, Seattle, WA, USA 6: Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA 7: Clinic of Hematology, Erasme University Hospital (ULB), Brussels, Belgium 8: Department of Haematology, Royal Free Hospital and School of Medicine, University College, London, UK 9: Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA 10: Division of Adult Stem Cell Transplantation, Texas Transplant Institute, San Antonio, TX, USA 11: Department of Hematology-Oncology, Institute of Hematology, Sant’ Orsola University Hospital, Bologna, Italy 12: Department of Hematology, Cliniques Universitaires Saint-Luc, Universite catholique de Louvain, Brussels, Belgium 13: Department of Hematology, Rigshospitalet University Hospital, Copenhagen, Denmark 14: Department of Stem Cell Transplantation, MD Anderson Cancer Center, University of Texas, Houston, TX, USA 15: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA 16: Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, IDIBAPS, University of Barcelona, Spain; Source Info: Dec2007, Vol. 21 Issue 12, p2452; Subject Term: CHRONIC lymphocytic leukemia; Subject Term: CHRONIC diseases; Subject Term: LEUKEMIA; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: SURGERY; Author-Supplied Keyword: CLL; Author-Supplied Keyword: hematopoietic stem cell transplantation; Author-Supplied Keyword: identical twin; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/sj.leu.2404928
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wagner, Robert F.
T1 - From medical images to multiple-biomarker microarrays.
JO - Medical Physics
JF - Medical Physics
Y1 - 2007/12//
VL - 34
IS - 12
M3 - Article
SP - 4944
EP - 4951
SN - 00942405
AB - A favorite cliché, often attributed to Yogi Berra, is “Prediction is difficult, especially about the future!” In this brief review, we shall recall some historical difficulties in predicting the future of diagnostic medical imaging—in particular, the modern technologies of CT and MRI—and examine the analogous situation in the emerging technology of diagnostic microarrays for the multiple-biomarker problem. All of these technologies began their lives as ill-conditioned problems, i.e., there was insufficient data to solve the central problem at hand. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSTIC imaging
KW - BIOCHEMICAL markers
KW - IMAGING systems in medicine
KW - NUCLEAR magnetic resonance
KW - MEDICAL physics
N1 - Accession Number: 27758766; Wagner, Robert F. 1; Affiliation: 1: Center for Devices and Radiological Health, FDA, 10903 New Hampshire Avenue, Building 62, Room 3126, Silver Spring, Maryland 20993-0002; Source Info: Dec2007, Vol. 34 Issue 12, p4944; Subject Term: DIAGNOSTIC imaging; Subject Term: BIOCHEMICAL markers; Subject Term: IMAGING systems in medicine; Subject Term: NUCLEAR magnetic resonance; Subject Term: MEDICAL physics; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 1 Black and White Photograph; Document Type: Article
L3 - 10.1118/1.2805252
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chaffin, Jeffrey G.
AU - Mangelsdorff, A. David
AU - Finstuen, Kenn
T1 - The Development of a Conceptual Model for Evaluating Dental Patient Satisfaction.
JO - Military Medicine
JF - Military Medicine
Y1 - 2007/12//
VL - 172
IS - 12
M3 - Article
SP - 1239
EP - 1244
PB - AMSUS
SN - 00264075
AB - The purpose of this study was to identify levels and predictors of patient satisfaction and develop a conceptual model for dental patient satisfaction in military treatment facilities. Respondents completed 658,443 surveys during 17 fiscal quarters, beginning with the fourth quarter of 2000. The final data set contained 309,261 surveys, with no missing data. Principal component factor analysis was used for data reduction and hierarchical multiple linear regression to assess the predictive effects of the dependent variables on the two independent variables: (1) overall satisfaction with today's visit and (2) overall satisfaction with the clinic. On a 7-point, bipolar adjective rating scale, patients' mean score was 6.53 regarding satisfaction with visit, suggesting that patients are highly satisfied. Patients' beliefs about care received and environment of care were the most important satisfaction attributes. These findings are useful in educating providers about the relationship of consumer satisfaction with the interpersonal experience. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONCEPTUAL models
KW - PATIENT satisfaction
KW - EVALUATION of dental services
KW - MILITARY dentistry
KW - DENTAL clinics
N1 - Accession Number: 27964369; Chaffin, Jeffrey G. 1,2 Mangelsdorff, A. David 3 Finstuen, Kenn 3; Affiliation: 1: Public Health Denial Officer, U.S. Army Dental Command, 2050 Worth Road, Fort Sam Houston, TX 78234 2: Dental Staff Officer, Department of the Army, Office of the Surgeon General, 5109 Leesburg Pike, Falls Church, VA 22041 3: Professor, U.S. Army-Baylor University Graduate Program in Healthcare and Business Administration, 3151 Scott Road, Building 2841, Fort Sam Houston, TX 78234; Source Info: Dec2007, Vol. 172 Issue 12, p1239; Subject Term: CONCEPTUAL models; Subject Term: PATIENT satisfaction; Subject Term: EVALUATION of dental services; Subject Term: MILITARY dentistry; Subject Term: DENTAL clinics; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Torma-Krajewski, J.
T1 - Ergonomics and design issues with prill trucks.
JO - Mining Technology
JF - Mining Technology
Y1 - 2007/12//
VL - 116
IS - 4
M3 - Article
SP - 153
EP - 157
PB - Taylor & Francis Ltd
SN - 14749009
AB - Access design features of four prill trucks were evaluated to determine musculoskeletal disorder risk factor exposures of powder crews. Evaluations consisted of crew interviews, videotaping of tasks, physical measurements and comparison of design features with standard specifications. Observed exposures included forceful exertions, awkward postures, forceful gripping and ground impact forces. Crew interviews indicated each of the four trucks had both positive and negative design features. Even though the trucks were manufactured between 1992 and 2002, the later models still had design features that encouraged work practices resulting in risk factor exposures. Access systems met some of the specifications for either ladder, step ladder or stairway requirements; access systems were often a combination of access systems. In absence of regulatory design standards, improvements can be accomplished by interviewing employees regarding the interface between the worker and existing equipment, and by following relevant standard specifications for a single access system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mining Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MINES & mineral resources
KW - MINERAL industries -- Equipment & supplies
KW - TRUCKS -- Evaluation
KW - MATERIALS handling
KW - PRODUCT design
KW - DISEASES -- Risk factors
KW - Equipment design
KW - ERGONOMICS
KW - MINING EQUIPMENT
N1 - Accession Number: 34561176; Torma-Krajewski, J. 1; Email Address: jht8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; Source Info: Dec2007, Vol. 116 Issue 4, p153; Subject Term: MINES & mineral resources; Subject Term: MINERAL industries -- Equipment & supplies; Subject Term: TRUCKS -- Evaluation; Subject Term: MATERIALS handling; Subject Term: PRODUCT design; Subject Term: DISEASES -- Risk factors; Author-Supplied Keyword: Equipment design; Author-Supplied Keyword: ERGONOMICS; Author-Supplied Keyword: MINING EQUIPMENT; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 541420 Industrial Design Services; Number of Pages: 5p; Illustrations: 2 Color Photographs, 2 Charts; Document Type: Article
L3 - 10.1179/174328608X318289
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Lee, Taewon
AU - Delongchamp, Robert
AU - Moland, Carrie
AU - Branham, William
AU - VonTungeln, Linda
AU - Beland, Fredrick
AU - Fuscoe, James
AU - Desai, Varsha
T1 - 18 Effect of neonatal exposure of 3′-azido-3′-deoxythymidine on the expression level of mitochondrial genes in the skeletal muscle of mouse as measured by mitochondria-specific microarray
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2007/12//
VL - 7
IS - 6
M3 - Abstract
SP - 409
EP - 409
SN - 15677249
N1 - Accession Number: 27640852; Lee, Taewon 1 Delongchamp, Robert 1 Moland, Carrie 1 Branham, William 1 VonTungeln, Linda 1 Beland, Fredrick 1 Fuscoe, James 1 Desai, Varsha; Affiliation: 1: National Center for Toxicological Research, U.S. FDA, Jefferson, AR, USA; Source Info: Dec2007, Vol. 7 Issue 6, p409; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.mito.2007.08.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bharti, Sanita
AU - Inoue, Hiroki
AU - Bharti, Kapil
AU - Hirsch, Dianne S.
AU - Zhongzhen Nie
AU - Hye-Young Yoon
AU - Artym, Vira
AU - Yamada, Kenneth M.
AU - Mueller, Susette C.
AU - Barr, Valarie A.
AU - Randazzo, Paul A.
T1 - Src-Dependent Phosphorylation of ASAP1 Regulates Podosomes.
JO - Molecular & Cellular Biology
JF - Molecular & Cellular Biology
Y1 - 2007/12//
VL - 27
IS - 23
M3 - Article
SP - 20
EP - 20
SN - 02707306
AB - Invadopodia are Src-induced cellular structures that are thought to mediate tumor invasion. ASAP1, an Arf GTPase-activating protein (GAP) containing Src homology 3 (SH3) and Bin, amphiphysin, and RVS161/167 (BAR) domains, is a substrate of Src that controls invadopodia. We have examined the structural requirements for ASAP1-dependent formation of invadopodia and related structures in NIH 3T3 fibroblasts called podosomes. We found that both predominant splice variants of ASAP1 (ASAP1a and ASAP1b) associated with invadopodia and podosomes. Podosomes were highly dynamic, with rapid turnover of both ASAP1 and actin. Reduction of ASAP1 levels by small interfering RNA blocked formation of invadopodia and podosomes. Podosomes were formed in NIH 3T3 fibroblasts in which endogenous ASAP1 was replaced with either recombinant ASAP1a or ASAP1b. ASAP1 mutants that lacked the Src binding site or GAP activity functioned as well as wild-type ASAP1 in the formation of podosomes. Recombinant ASAP1 lacking the BAR domain, the SH3 domain, or the Src phosphorylation site did not support podosome formation. Based on these results, we conclude that ASAP1 is a critical target of tyrosine kinase signaling involved in the regulation of podosomes and invadopodia and speculate that ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular & Cellular Biology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTO-oncogenes
KW - CANCER genes
KW - PHOSPHORYLATION
KW - GTPASE-activating protein
KW - FIBROBLASTS
N1 - Accession Number: 27681286; Bharti, Sanita 1 Inoue, Hiroki 1 Bharti, Kapil 2 Hirsch, Dianne S. 3 Zhongzhen Nie 1 Hye-Young Yoon 1 Artym, Vira 4,5 Yamada, Kenneth M. 4 Mueller, Susette C. 5 Barr, Valarie A. 1 Randazzo, Paul A. 1; Email Address: Randazzo@helix.nih.gov; Affiliation: 1: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute 2: Mammalian Development Section, National Institute of Neurological Disorders and Stroke 3: Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 4: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 5: Georgetown University, Washington, DC; Source Info: Dec2007, Vol. 27 Issue 23, p20; Subject Term: PROTO-oncogenes; Subject Term: CANCER genes; Subject Term: PHOSPHORYLATION; Subject Term: GTPASE-activating protein; Subject Term: FIBROBLASTS; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/MCB.01781-06
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27681286&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Woods, Courtney G.
AU - Witt, Sarah E.
AU - Rusyn, Ivan
T1 - Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2007/12//
VL - 625
IS - 1/2
M3 - Article
SP - 62
EP - 71
SN - 00275107
AB - Abstract: Peroxisome proliferators are potent rodent liver carcinogens that act via a non-genotoxic mechanism. The mode of action of these agents in rodent liver includes increased cell proliferation, decreased apoptosis, secondary oxidative stress and other events; however, it is not well understood how peroxisome proliferators are triggering the plethora of the molecular signals leading to cancer. Epigenetic changes have been implicated in the mechanism of liver carcinogenesis by a number of environmental agents. Short-term treatment with peroxisome proliferators and other non-genotoxic carcinogens leads to global and locus-specific DNA hypomethylation in mouse liver, events that were suggested to correlate with a burst of cell proliferation. In the current study, we investigated the effects of long-term exposure to a model peroxisome proliferator WY-14,643 on DNA and histone methylation. Male SV129mice were fed a control or WY-14,643-containing (1000ppm) diet for one week, five weeks or five months. Treatment with WY-14,643 led to progressive global hypomethylation of liver DNA as determined by an HpaII-based cytosine extension assay with the maximum effect reaching over 200% at five months. Likewise, trimethylation of histone H4 lysine 20 and H3 lysine 9 was significantly decreased at all time points. The majority of cytosine methylation in mammals resides in repetitive DNA sequences. In view of this, we measured the effect of WY-14,643 on the methylation status of major and minor satellites, as well as in IAP, LINE1 and LINE2 elements in liver DNA. Exposure to WY-14,643 resulted in a gradual loss of cytosine methylation in major and minor satellites, IAP, LINE1 and LINE2 elements. The epigenetic changes correlated with the temporal effects of WY-14,643 on cell proliferation rates in liver, but no sustained effect on c-Myc promoter methylation was observed. Finally, WY-14,643 had no effect on DNA and histone methylation status in Pparα-null mice at any of the time points considered in this study. These data indicate the importance of epigenetic alterations in the mechanism of action of peroxisome proliferators and the key role of Pparα. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEROXISOMES
KW - CARCINOGENS
KW - LIVER
KW - MICE as laboratory animals
KW - Cancer
KW - DNA methylation
KW - Epigenetics
KW - Liver
KW - Peroxisome proliferators
N1 - Accession Number: 27356868; Pogribny, Igor P. 1 Tryndyak, Volodymyr P. 1 Woods, Courtney G. 2 Witt, Sarah E. 1 Rusyn, Ivan 2; Email Address: iir@unc.edu; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA; Source Info: Dec2007, Vol. 625 Issue 1/2, p62; Subject Term: PEROXISOMES; Subject Term: CARCINOGENS; Subject Term: LIVER; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Epigenetics; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Peroxisome proliferators; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2007.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27356868&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chumakov, Konstantin
AU - Ehrenfeld, Ellie
AU - Wimmer, Eckard
AU - Agol, Vadim I.
T1 - Vaccination against polio should not be stopped.
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
Y1 - 2007/12//
VL - 5
IS - 12
M3 - Article
SP - 952
EP - 958
PB - Nature Publishing Group
SN - 17401526
AB - The striking 50-year-long decline in the incidence of poliomyelitis has stalled in the past 7 years, which has led to calls for an urgent re-assessment of eradication and post-eradication campaign strategies. The current plan of eliminating the circulation of wild poliovirus so that further immunization will be unnecessary does not take into account recent scientific data and political realities that limit the likelihood that this strategy can sustain prevention of the disease. It is crucially important that high levels of population immunity are maintained against polio in the foreseeable future. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Microbiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLIO
KW - VACCINATION
KW - POLIOMYELITIS vaccine
KW - IMMUNIZATION
N1 - Accession Number: 27501399; Chumakov, Konstantin 1 Ehrenfeld, Ellie 2; Email Address: eehrenfeld@niaid.nih.gov Wimmer, Eckard 3 Agol, Vadim I. 4; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, USA 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA 3: Department of Molecular Genetics and Microbiology, Stony Brook University, School of Medicine, Stony Brook, New York, New York 11794, USA 4: M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow 142782, Russia; Source Info: Dec2007, Vol. 5 Issue 12, p952; Subject Term: POLIO; Subject Term: VACCINATION; Subject Term: POLIOMYELITIS vaccine; Subject Term: IMMUNIZATION; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 1 Color Photograph, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1038/nrmicro1769
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27501399&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Galson, Steven K.
T1 - Protect, Promote, Advance Health.
JO - Officer
JF - Officer
Y1 - 2007/12//
VL - 83
IS - 10
M3 - Speech
SP - 52
EP - 54
SN - 00300268
AB - The article presents a speech by Steven K. Galson, acting surgeon general of the U.S. Public Health Service, in which he discussed the importance of the Inactive Reserve Corps of the Public Health Service.
KW - MILITARY reserve forces
KW - GALSON, Steven K.
N1 - Accession Number: 27892709; Galson, Steven K. 1; Affiliation: 1: Acting Surgeon General, U.S. Public Health Service, U.S. Department of Health and Human Services; Source Info: Dec2007, Vol. 83 Issue 10, p52; Subject Term: MILITARY reserve forces; NAICS/Industry Codes: 928110 National Security; People: GALSON, Steven K.; Number of Pages: 3p; Illustrations: 4 Color Photographs; Document Type: Speech
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105722671
T1 - Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas.
AU - Senderowicz AM
AU - Johnson JR
AU - Sridhara R
AU - Zimmerman P
AU - Justice R
AU - Pazdur R
Y1 - 2007/12//
N1 - Accession Number: 105722671. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article; CEU; clinical trial; exam questions; research; tables/charts. Note: For CE see page 1754. Commentary: Fleshman J, Duff M, James P. The Senderowicz et al article reviewed: advocate's perspective. Pancreatic cancer: incremental success in overcoming a major therapeutic challenge. (ONCOLOGY (08909091)) Dec2007; 21 (14): 1712-1715; Ko AH. The Senderowicz/Johnson/Sridhara et al article reviewed. Erlotinib in pancreatic cancer: a major breakthrough? (ONCOLOGY (08909091)) Dec2007; 21 (14): 1706-1709. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care. NLM UID: 8712059.
KW - Adenocarcinoma -- Drug Therapy
KW - Antineoplastic Agents -- Therapeutic Use
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Enzyme Inhibitors -- Therapeutic Use
KW - Growth Substances -- Therapeutic Use
KW - Pancreatic Neoplasms -- Drug Therapy
KW - Aged
KW - Antineoplastic Agents -- Administration and Dosage
KW - Clinical Trials
KW - Double-Blind Studies
KW - Education, Continuing (Credit)
KW - Enzyme Inhibitors -- Administration and Dosage
KW - Female
KW - Fisher's Exact Test
KW - Growth Substances -- Adverse Effects
KW - Kaplan-Meier Estimator
KW - Male
KW - Middle Age
KW - Neoplasm Metastasis -- Drug Therapy
KW - Neoplasm Staging
KW - Phosphotransferases -- Antagonists and Inhibitors
KW - Placebos
KW - Survival Analysis
KW - Human
SP - 1696
EP - 1706
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 21
IS - 14
CY - Norwalk, Connecticut
PB - UBM Medica
AB - Erlotinib (Tarceva) is a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor initially approved by the US Food and Drug Administration for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. In this report, we present the pivotal study that led to the approval of erlotinib in combination with gemcitabine (Gemzar) in patients with locally advanced/metastatic chemonaive pancreatic cancer patients. The combination demonstrated a statistically significant increase in overall survival accompanied by an increase in toxicity. Physicians and patients now have a new option for the treatment of locally advanced/metastatic adenocarcinoma of the pancreas.
SN - 0890-9091
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 18247017.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105722671&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105829879
T1 - The relationship of cigarette smoking to postoperative complications from dental extractions among female inmates.
AU - Heng CK
AU - Badner VM
AU - Clemens DL
AU - Mercer LT
AU - Mercer DW
Y1 - 2007/12//
N1 - Accession Number: 105829879. Language: English. Entry Date: 20080307. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Dental Care; Perioperative Care. NLM UID: 101576782.
KW - Dry Socket -- Etiology
KW - Smoking
KW - Tooth Extraction -- Adverse Effects
KW - Adult
KW - Chi Square Test
KW - Dry Socket -- Epidemiology
KW - Female
KW - Prisoners
KW - Human
SP - 757
EP - 762
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
JA - ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL ENDO
VL - 104
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVES: The purpose of this study is to assess the contribution of smoking to postoperative complications, including alveolar osteitis (dry socket), after dental extractions. In addition, it attempts to determine the effect of the ban imposed on tobacco use in the prison on postoperative complications. STUDY DESIGN: All inmates having dental extractions at the Federal Correctional Institution in Danbury, CT, during the period January 2004 to April 2005, were included in this study (N = 219; mean age = 37.7 years). Data on postextraction complications were analyzed for association with smoking by using the chi-square test. Significance was set at P < .05. RESULTS: The incidences of overall complications and alveolar osteitis were 19.6% and 5.0%, respectively. It was found that (1) there was a significant difference in overall complications between smokers and nonsmokers (P = .02), (2) there was a significant difference in the incidence of alveolar osteitis between mandibular third molar and other extractions, regardless of smoking status (P = .02), (3) surgical trauma contributed significantly to both an increase in total complications (P = .05) and alveolar osteitis (P = .01), and (4) smoking appeared to be a contributing factor to increased complications among multiple extractions (P = .03). CONCLUSION: In this study, smoking, mandibular third molars, and surgical trauma were significantly associated with the increased incidence of overall complications including alveolar osteitis.
SN - 1079-2104
AD - U.S. Public Health Service, Federal Correctional Institution, Danbury, CT 06811, USA. cheng@bop.gov
U2 - PMID: 17764988.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105829879&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tomashek, Kay Marie
AU - Wallman, Carol
T1 - Cobedding Twins and Higher-Order Multiples in a Hospital Setting.
JO - Pediatrics
JF - Pediatrics
Y1 - 2007/12//
VL - 120
IS - 6
M3 - Article
SP - 1359
EP - 1366
SN - 00314005
AB - The article presents a review of published literature on the practice of cobedding twins and higher-order multiples in U.S. hospitals. The author notes that some anecdotal reports and observational studies suggested that cobedding may have beneficial physiological and psychological effects on infants including the stabilization of vital signs and improved regulation of body temperature, enhanced growth and development and a decrease in the number of episodes of apnea and bradycardia. In 5 analytical studies, 2 experimental studies suggested that cobedded multiples may gain weight more readily than separately bedded multiples. Also examined in the studies are the differences in physiological stress between cobedded and separately bedded multiples.
KW - LITERATURE reviews
KW - TWINS
KW - MULTIPLE birth
KW - HOSPITALS
KW - BODY temperature regulation
KW - INFANT development
KW - BRADYCARDIA
KW - APNEA
KW - UNITED States
N1 - Accession Number: 32133130; Tomashek, Kay Marie 1; Email Address: kct9@cdc.gov Wallman, Carol; Affiliation: 1: US Public Health Service, Epidemiology Activity, Dengue Branch, Division of Vector-Borne Infectious Disease, Centers for Disease Control and Prevention, 1324 Calle Caadña, San Juan, Puerto Rico 00920; Source Info: Dec2007, Vol. 120 Issue 6, p1359; Subject Term: LITERATURE reviews; Subject Term: TWINS; Subject Term: MULTIPLE birth; Subject Term: HOSPITALS; Subject Term: BODY temperature regulation; Subject Term: INFANT development; Subject Term: BRADYCARDIA; Subject Term: APNEA; Subject Term: UNITED States; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1542/peds.2006-3096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32133130&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105830227
T1 - Cobedding twins and higher-order multiples in a hospital setting.
AU - Tomashek KM
AU - Wallman C
Y1 - 2007/12//
N1 - Accession Number: 105830227. Corporate Author: American Academy of Pediatrics. Committee on Fetus and Newborn. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Beds and Mattresses
KW - Intensive Care, Neonatal -- Methods
KW - Multiple Offspring
KW - Hospitals
KW - Infant, Newborn
KW - Twins
KW - United States
SP - 1359
EP - 1366
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 120
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - US Public Health Service, Epidemiology Activity, Dengue Branch, Division of Vector-Borne Infectious Disease, Centers for Disease Control and Prevention, 1324 Calle Cañada, San Juan, Puerto Rico. kct9@cdc.gov
U2 - PMID: 18055686.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105830227&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Brown, Jeffrey S.
AU - Kulldorff, Martin
AU - Chan, K. Arnold
AU - Davis, Robert L.
AU - Graham, David
AU - Pettus, Parker T.
AU - Andrade, Susan E.
AU - Raebel, Marsha A.
AU - Herrinton, Lisa
AU - Roblin, Douglas
AU - Boudreau, Denise
AU - Smith, David
AU - Gurwitz, Jerry H.
AU - Gunter, Margaret J.
AU - Platt, Richard
T1 - Early detection of adverse drug events within population-based health networks: application of sequential testing methods.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2007/12//
VL - 16
IS - 12
M3 - Article
SP - 1275
EP - 1284
SN - 10538569
AB - Purpose Active surveillance of population-based health networks may improve the timeliness of detection of adverse drug events (ADEs). Active monitoring requires sequential analysis methods. Our objectives were to (1) evaluate the utility of automated healthcare claims data for near real-time drug adverse event surveillance and (2) identify key methodological issues related to the use of healthcare claims data for real-time drug safety surveillance. Methods We assessed the ability to detect ADEs using historical data from nine health plans involved in the HMO Research Network's Center for Education and Research on Therapeutics (CERT). Analyses were performed using a maximized sequential probability ratio test (maxSPRT). Five drug-event pairs representing known associations with an ADE and two pairs representing 'negative controls' were analyzed. Results Statistically significant ( p < 0.05) signals of excess risk were found in four of the five drug-event pairs representing known associations; no signals were found for the negative controls. Signals were detected between 13 and 39 months after the start of surveillance. There was substantial variation in the number of exposed and expected events at signal detection. Conclusions Prospective, periodic evaluation of routinely collected data can provide population-based estimates of medication-related adverse event rates to support routine, timely post-marketing surveillance for selected ADEs. Copyright © 2007 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707765; Brown, Jeffrey S. 1,2; Kulldorff, Martin 1; Chan, K. Arnold 3,4; Davis, Robert L. 5; Graham, David 6; Pettus, Parker T. 1,2; Andrade, Susan E. 2,7; Raebel, Marsha A. 2,8; Herrinton, Lisa 2,9; Roblin, Douglas 2,10; Boudreau, Denise 2,11; Smith, David 2,12; Gurwitz, Jerry H. 2,7; Gunter, Margaret J. 2,13; Platt, Richard 1,2; Affiliations: 1: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA; 2: The HMO Research Network Center for Education and Research in Therapeutics, Boston, MA, USA; 3: Harvard School of Public Health, Boston, MA, USA; 4: i3 Drug Safety, Waltham, MA, USA; 5: Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, GA, USA; 6: Office of Drug Safety, Food and Drug Administration, Rockville, MD, USA; 7: Meyers Primary Care Institute (University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan), Worcester, MA, USA; 8: Kaiser Permanente Colorado, Denver, CO, USA; 9: Kaiser Permanente Northern California, Oakland, CA, USA; 10: Kaiser Permanente Georgia, Atlanta, GA, USA; 11: Center for Health Studies, Group Health Cooperative, Seattle, WA, USA; 12: Kaiser Permanente Northwest, Portland, OR, USA; 13: Lovelace Clinic Foundation, Albuquerque, NM, USA; Issue Info: Dec2007, Vol. 16 Issue 12, p1275; Number of Pages: 10p; Document Type: Article
L3 - 10.1002/pds.1509
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105885201
T1 - Horizons of context: understanding the police decision to arrest people with mental illness.
AU - Morabito MS
AU - Morabito, Melissa Schaefer
Y1 - 2007/12//
N1 - Accession Number: 105885201. Language: English. Entry Date: 20080411. Revision Date: 20161125. Publication Type: journal article; research; review. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Grant Information: P20 MH068170/MH/NIMH NIH HHS/United States. NLM UID: 9502838.
KW - Coercion
KW - Criminology
KW - Decision Making
KW - Police
KW - Psychiatric Patients -- Legislation and Jurisprudence
KW - Social Control
KW - United States
SP - 1582
EP - 1587
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 58
IS - 12
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - The criminalization hypothesis assumes that deinstitutionalization coupled with inadequate police training has led to the increased arrest of people with mental illness. Arrest is viewed as a means to manage the troublesome behavior that often results from mental illness. Supporting research has emphasized the contributing role that illness plays in the arrest decision. This assumption largely ignores an extant criminal justice literature on the factors that influence arrest. On the basis of a review of this criminal justice literature, beginning with Bittner's 1967 seminal work, a framework is proposed that incorporates three contexts -- manipulative, temporal, and scenic -- surrounding the police encounter and the relationship of these contexts to mental illness. These three "horizons" incorporate the characteristics of the community, the offender, and the incident, all of which are recognized as influential in shaping police discretion. The scenic horizon is indicative of the features of the community. The temporal horizon includes police knowledge that stretches beyond the specific incident and officer characteristics. The manipulative horizon involves the current incident from the standpoint of the officer and includes considerations of safety for the community as well as the immediate concerns of the officer. Implications of this framework are then explored with respect to both police and mental health service mandates.
SN - 1075-2730
AD - Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ, USA
AD - Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, New Jersey.
U2 - PMID: 18048560.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Contrera, Joseph F.
AU - Kruhlak, Naomi L.
AU - Matthews, Edwin J.
AU - Benz, R. Daniel
T1 - Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/12//
VL - 49
IS - 3
M3 - Article
SP - 172
EP - 182
SN - 02732300
AB - Abstract: This report presents a comparison of the predictive performance of MC4PC and MDL-QSAR software as well as a method for combining the predictions from both programs to increase overall accuracy. The conclusions are based on 10×10% leave-many-out internal cross-validation studies using 1540 training set compounds with 2-year rodent carcinogenicity findings. The models were generated using the same weight of evidence scoring method previously developed [Matthews, E.J., Contrera, J.F., 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharmacol. 28, 242–264.]. Although MC4PC and MDL-QSAR use different algorithms, their overall predictive performance was remarkably similar. Respectively, the sensitivity of MC4PC and MDL-QSAR was 61 and 63%, specificity was 71 and 75%, and concordance was 66 and 69%. Coverage for both programs was over 95% and receiver operator characteristic (ROC) intercept statistic values were above 2.00. The software programs had complimentary coverage with none of the 1540 compounds being uncovered by both MC4PC and MDL-QSAR. Merging MC4PC and MDL-QSAR predictions improved the overall predictive performance. Consensus sensitivity increased to 67%, specificity to 84%, concordance to 76%, and ROC to 4.31. Consensus rules can be tuned to reflect the priorities of the user, so that greater emphasis may be placed on predictions with high sensitivity/low false negative rates or high specificity/low false positive rates. Sensitivity was optimized to 75% by reclassifying all compounds predicted to be positive in MC4PC or MDL-QSAR as positive, and specificity was optimized to 89% by reclassifying all compounds predicted negative in MC4PC or MDL-QSAR as negative. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QSAR (Biochemistry)
KW - Carcinogenesis
KW - Carcinogenicity
KW - Genetic toxicology
KW - Chemoinformatics
KW - Consensus prediction
KW - Discriminant analysis
KW - E-state
KW - In silico
KW - Predictive toxicology
KW - QSAR
KW - Topological descriptors
N1 - Accession Number: 27516618; Contrera, Joseph F.; Email Address: Joseph.Contrera@fda.hhs.gov; Kruhlak, Naomi L. 1; Matthews, Edwin J. 1; Benz, R. Daniel 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Mail Drop 1603, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA; Issue Info: Dec2007, Vol. 49 Issue 3, p172; Thesaurus Term: QSAR (Biochemistry); Thesaurus Term: Carcinogenesis; Thesaurus Term: Carcinogenicity; Thesaurus Term: Genetic toxicology; Author-Supplied Keyword: Chemoinformatics; Author-Supplied Keyword: Consensus prediction; Author-Supplied Keyword: Discriminant analysis; Author-Supplied Keyword: E-state; Author-Supplied Keyword: In silico; Author-Supplied Keyword: Predictive toxicology; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Topological descriptors; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.yrtph.2007.07.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sartorelli, Pietro
AU - Ahlers, Heinz W.
AU - Alanko, Kristiina
AU - Chen-Peng, Chen
AU - Cherrie, John W.
AU - Drexler, Hans
AU - Kezic, Sanja
AU - Johanson, Gunnar
AU - Larese Filon, Francesca
AU - Maina, Giovanni
AU - Montomoli, Loretta
AU - Nielsen, Jesper Bo
T1 - How to improve skin notation. Position paper from a workshop
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2007/12//
VL - 49
IS - 3
M3 - Article
SP - 301
EP - 307
SN - 02732300
AB - Abstract: The ICOH Scientific Committee on Occupational and Environmental Dermatoses organized an International Workshop on “Dermal risk assessment at workplace” with the aim of focussing on the different ways of approaching the concept of skin notation (S) for chemicals. The Workshop participants presented their ideas on several aspects of S such as the problems related to the absorption through the compromised skin, the different approaches to S and models that can be used as alternatives to S. Participants agreed to produce a position paper with the goal of exploring the actions needed to improve the S system towards international harmonization. They consider that further discussions are needed to obtain an international consensus, but at the same time they believe that by improving and harmonizing systems for setting S we can make an important contribution to improving health of people with potential dermal exposure to chemicals at work. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Absorption
KW - Skin diseases
KW - Health status indicators
KW - Dermal risk assessment
KW - Skin notation
N1 - Accession Number: 27516630; Sartorelli, Pietro 1; Email Address: sartorelli@unisi.it; Ahlers, Heinz W. 2; Alanko, Kristiina 3; Chen-Peng, Chen 2; Cherrie, John W. 4; Drexler, Hans 5; Kezic, Sanja 6; Johanson, Gunnar 7; Larese Filon, Francesca 8; Maina, Giovanni 9; Montomoli, Loretta 1; Nielsen, Jesper Bo 10; Affiliations: 1: Departmental Section of Occupational Medicine and Toxicology, University of Siena, Italy; 2: National Institute for Occupational Safety and Health, USA; 3: Finnish Institute of Occupational Health, Helsinki, Finland; 4: Institute of Occupational Medicine, Edinburgh, United Kingdom; 5: Institut and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Germany; 6: Coronel Institute of Occupational Health, Academic Medical Centre, Amsterdam, Netherlands; 7: Work Environment Toxicology, Karolinska Institutet, Stockholm, Sweden; 8: Occupational Medicine, University of Trieste, Italy; 9: Institute of Occupational Medicine, University of Turin, Italy; 10: Institute of Public Health, University of Southern Denmark, Odense, Denmark; Issue Info: Dec2007, Vol. 49 Issue 3, p301; Thesaurus Term: Health risk assessment; Thesaurus Term: Absorption; Subject Term: Skin diseases; Subject Term: Health status indicators; Author-Supplied Keyword: Dermal risk assessment; Author-Supplied Keyword: Skin notation; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.yrtph.2007.08.008
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wright, Douglas A.
AU - Bobashev, Georgiy
AU - Folsom, Ralph
T1 - Understanding the Relative Influence of Neighborhood, Family, and Youth on Adolescent Drug Use.
JO - Substance Use & Misuse
JF - Substance Use & Misuse
Y1 - 2007/12//
VL - 42
IS - 14
M3 - Article
SP - 2159
EP - 2171
PB - Taylor & Francis Ltd
SN - 10826084
AB - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing "components of variance" in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative "importance." We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Prevention
KW - YOUTH & drugs
KW - MARIJUANA abuse
KW - PREVENTION
KW - DRUGS of abuse
KW - FAMILIES -- Study & teaching
KW - NEIGHBORHOODS -- Social aspects
KW - HOUSEHOLDS
KW - COMMUNITY relations
KW - UNITED States
KW - family
KW - household
KW - neighborhood
KW - protective factors
KW - risk factors
KW - variance components
N1 - Accession Number: 27979353; Wright, Douglas A. 1; Email Address: Douglas.Wright@samhsa.hhs.gov Bobashev, Georgiy 2 Folsom, Ralph 2; Affiliation: 1: Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA 2: RTI International, Research Triangle Park, North Carolina, USA; Source Info: 2007, Vol. 42 Issue 14, p2159; Subject Term: SUBSTANCE abuse -- Prevention; Subject Term: YOUTH & drugs; Subject Term: MARIJUANA abuse; Subject Term: PREVENTION; Subject Term: DRUGS of abuse; Subject Term: FAMILIES -- Study & teaching; Subject Term: NEIGHBORHOODS -- Social aspects; Subject Term: HOUSEHOLDS; Subject Term: COMMUNITY relations; Subject Term: UNITED States; Author-Supplied Keyword: family; Author-Supplied Keyword: household; Author-Supplied Keyword: neighborhood; Author-Supplied Keyword: protective factors; Author-Supplied Keyword: risk factors; Author-Supplied Keyword: variance components; NAICS/Industry Codes: 814110 Private Households; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/10826080701212675
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27979353&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Understanding the Relative Influence of Neighborhood, Family, and Youth on Adolescent Drug Use.
AU - Wright, Douglas A.
AU - Bobashev, Georgiy
AU - Folsom, Ralph
JO - Substance Use & Misuse
JF - Substance Use & Misuse
Y1 - 2007/12//
VL - 42
IS - 14
SP - 2159
EP - 2171
SN - 10826084
N1 - Accession Number: 27979353; Author: Wright, Douglas A.: 1 email: Douglas.Wright@samhsa.hhs.gov. Author: Bobashev, Georgiy: 2 Author: Folsom, Ralph: 2 ; Author Affiliation: 1 Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA: 2 RTI International, Research Triangle Park, North Carolina, USA; No. of Pages: 13; Language: English; Publication Type: Article; Update Code: 20071221
N2 - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing "components of variance" in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative "importance." We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs. ABSTRACT FROM AUTHOR
KW - *SUBSTANCE abuse
KW - *PREVENTION
KW - *MARIJUANA abuse
KW - *DRUGS of abuse
KW - YOUTH & drugs
KW - FAMILIES -- Study & teaching
KW - NEIGHBORHOODS -- Social aspects
KW - HOUSEHOLDS
KW - COMMUNITY relations
KW - UNITED States
KW - family
KW - household
KW - neighborhood
KW - protective factors
KW - risk factors
KW - variance components
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=27979353&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - GEN
AU - Petsonk, Edward L.
AU - Hnizdo, Eva
AU - Attfield, Mkhael
T1 - Definition of COPD GOLD stage I.
JO - Thorax
JF - Thorax
Y1 - 2007/12//
VL - 62
IS - 12
M3 - Letter
SP - 1107
EP - 1108
SN - 00406376
AB - A letter to the editor is presented in response to the article on chronic obstructive pulmonary disease (COPD) that was published in the previous issue.
KW - LETTERS to the editor
KW - OBSTRUCTIVE lung diseases
N1 - Accession Number: 27885463; Petsonk, Edward L. 1; Email Address: elp2@cdc.gov Hnizdo, Eva 1 Attfield, Mkhael 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Dec2007, Vol. 62 Issue 12, p1107; Subject Term: LETTERS to the editor; Subject Term: OBSTRUCTIVE lung diseases; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kiki B. Hellman
AU - Robert M. Nerem
T1 - Editorial: Advancing Tissue Engineering and Regenerative Medicine.
JO - Tissue Engineering
JF - Tissue Engineering
Y1 - 2007/12//
VL - 13
IS - 12
M3 - Article
SP - 2823
EP - 2824
SN - 10763279
N1 - Accession Number: 47503342; Kiki B. Hellman 1,2 Robert M. Nerem 3; Affiliation: 1: The Hellman Group, LLC, Clarksburg, Maryland. 2: Formerly Senior Scientist, Food and Drug Administration; Co-Chair, Multi-Agency Tissue Engineering Science Interagency Working Group, 2000–2003. 3: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.; Source Info: Dec2007, Vol. 13 Issue 12, p2823; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harper, Susan B.
AU - Dertinger, Stephen D.
AU - Bishop, Michelle E.
AU - Lynch, Anthony M.
AU - Lorenzo, Maria
AU - Saylor, Michelle
AU - MacGregor, James T.
T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes III. An Efficient Method of Monitoring Chromosomal Damage in the Beagle Dog.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2007/12//
VL - 100
IS - 2
M3 - Article
SP - 406
EP - 414
SN - 10966080
AB - Erythrocyte-based micronucleus tests have traditionally analyzed bone marrow because splenic filtration in most species removes micronucleated cells from peripheral blood. We have evaluated a flow cytometric method for monitoring micronucleated reticulocyte frequencies (%MN-RET) in the peripheral blood of beagle dogs treated with cyclophosphamide (CP) and have found that analysis of micronucleated reticulocytes (MN-RETs) in peripheral blood is a suitable surrogate for bone marrow analysis. The three-color flow cytometric method uses anti-CD71 labeling to identify reticulocytes and Plasmodium berghei–containing erythrocytes as a calibration standard. The spontaneous %MN-RET determined by flow cytometry was 0.31 ± 0.09% (n = 22) for peripheral blood, compared with 0.38 ± 0.13% (SD, n = 12) for bone marrow, and 0.27 ± 0.08% (n = 12) for peripheral blood by microscopic scoring with acridine orange staining. The kinetics of appearance and disappearance of MN-RETs in blood were determined by collecting daily samples after iv treatment with CP. The maximum frequency occurred ∼48 h after dosing. Frequencies of MN-RETs in peripheral blood at steady state following daily CP treatment were 55–68% of corresponding bone marrow values assessed by microscopy and 55–112% as assessed by flow cytometry. This difference is presumably due to splenic removal, which appears slightly less stringent than that previously reported for CP-treated Sprague-Dawley rats. Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMOSOME abnormalities
KW - NUCLEOLUS
KW - FLOW cytometry
KW - RETICULOCYTES
KW - BONE marrow
KW - blood
KW - bone marrow
KW - chromosomal damage
KW - flow cytometry
KW - micronucleus
KW - reticulocytes
N1 - Accession Number: 44394033; Harper, Susan B. 1,2 Dertinger, Stephen D. 3 Bishop, Michelle E. 4 Lynch, Anthony M. 5 Lorenzo, Maria 2 Saylor, Michelle 2 MacGregor, James T. 6; Email Address: jtmacgregor@earthlink.net; Affiliation: 1: Department of Veterans Affairs, Washington, DC 20422 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD 20708 3: Litron Laboratories, Rochester, NY 14623 4: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 5: GlaxoSmithKline Research & Development, Herts, SG12 0DP, UK 6: Toxicology Consulting Services, Arnold, MD 21012; Source Info: Dec2007, Vol. 100 Issue 2, p406; Subject Term: CHROMOSOME abnormalities; Subject Term: NUCLEOLUS; Subject Term: FLOW cytometry; Subject Term: RETICULOCYTES; Subject Term: BONE marrow; Author-Supplied Keyword: blood; Author-Supplied Keyword: bone marrow; Author-Supplied Keyword: chromosomal damage; Author-Supplied Keyword: flow cytometry; Author-Supplied Keyword: micronucleus; Author-Supplied Keyword: reticulocytes; Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfm241
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44394033&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Knight, Tamara Raphael
AU - Choudhuri, Supratim
AU - Klaassen, Curtis D.
T1 - Constitutive mRNA Expression of Various Glutathione S-Transferase Isoforms in Different Tissues of Mice.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2007/12//
VL - 100
IS - 2
M3 - Article
SP - 513
EP - 524
SN - 10966080
AB - Glutathione S-transferase (Gst) enzymes are instrumental in protecting cellular macromolecules against electrophiles and products of oxidative stress. Of interest primarily to pharmacologists and toxicologists is the ability of these enzymes to metabolize cancer chemotherapeutic drugs, insecticides, herbicides, and carcinogens. Thus, constitutive expression of Gsts might determine a tissue's ability to handle certain forms of chemical stress. In the present study, the constitutive mRNA expression of 19 different Gst enzymes was investigated in 14 different tissues in mice. The information obtained from the present study could be distilled into a few generalized principles: in all tissues examined, multiple isoforms of Gst were constitutively expressed; several isoforms, such as Gstk1, Gstm1, Gstm4, Gstm6, and Gstt1, were expressed in most of the tissues studied; at least five Gst isoforms were highly expressed in the gonads, about three in heart, and at least one in brain (Gstm5). Gender differences in the expression of various Gst isoforms were pronounced. With a few exceptions, most of the Gst isoforms expressed in kidney showed higher expression in females than males; the same trend was observed for heart and gonads. At least eight Gst isoforms showed very high expression in stomach. This was a unique finding in the current study because drug-metabolizing enzymes that are highly expressed in the gastrointestinal (GI) tract tend to have the highest expression in small intestine with low or no expression in the stomach. In summary, most Gst isoforms are most highly expressed in the GI tract and liver, which strongly suggests an important role of many Gst isoforms in detoxification of ingested xenobiotics. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTATHIONE
KW - TRANSFERASES
KW - BIOCHEMISTRY
KW - MESSENGER RNA
KW - ENZYMES
KW - bDNA
KW - glutathione transferase
KW - Gst
KW - mRNA
KW - tissue distribution
N1 - Accession Number: 44394021; Knight, Tamara Raphael 1,2 Choudhuri, Supratim 1,3 Klaassen, Curtis D. 1,4; Email Address: cklaasse@kumc.edu; Affiliation: 1: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 2: Center for Toxicology and Environmental Health, L.L.C., Little Rock, Arkansas 72201 3: Food and Drug Administration, Center for Food Safety and Applied Nutrition, OFAS/DBGNR, College Park, Maryland 20740 4: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS; Source Info: Dec2007, Vol. 100 Issue 2, p513; Subject Term: GLUTATHIONE; Subject Term: TRANSFERASES; Subject Term: BIOCHEMISTRY; Subject Term: MESSENGER RNA; Subject Term: ENZYMES; Author-Supplied Keyword: bDNA; Author-Supplied Keyword: glutathione transferase; Author-Supplied Keyword: Gst; Author-Supplied Keyword: mRNA; Author-Supplied Keyword: tissue distribution; Number of Pages: 12p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfm233
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valerio Jr., Luis G.
T1 - Mammalian Iron Metabolism.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2007/12//
VL - 17
IS - 9
M3 - Article
SP - 497
EP - 517
PB - Taylor & Francis Ltd
SN - 15376516
AB - Iron is an essential transition metal for mammalian cellular and tissue viability. It is critical to supplying oxygen through heme, the mitochondrial respiratory chain, and enzymes such as ribonucleotide reductase. Mammalian organisms have evolved with the means of regulating the metabolism of iron, because if left unregulated, the resulting excess amounts of iron may induce chronic toxicities affecting multiple organ systems. Several homeostatic mechanisms exist to control the amount of intestinal dietary iron uptake, cellular iron uptake, distribution, and export. Within these processes, numerous molecular participants have been identified because of advancements in basic cell biology and efforts in disease-based research of iron storage abnormalities. For example, dietary iron uptake across the intestinal duodenal mucosa is mediated by an intramembrane divalent metal transporter 1 (DMT1), and cellular iron efflux involves ferroportin, the only known iron exporter. In addition to duodenal enterocytes, ferroportin is present in other cell types, and exports iron into plasma. Ferroportin was recently discovered to be regulated by the expression of the circulating hormone hepcidin, a small peptide synthesized in hepatocytes. These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload. Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1). In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism. From a toxicological standpoint, posttranscriptional regulation of these genes aids in the sequestration, control, and hence prevention of cytotoxic effects from free-floating nontransferrin-bound iron. Given the importance of dietary iron in normal physiology, its potential to induce chronic toxicity, and recent discoveries in the regulation of human iron metabolism by hepcidin, this review will address the regulatory mechanisms of normal iron metabolism in mammals with emphasis on dietary exposure. It is the goal of this review that this information may provide in a concise format our current understanding of major pathways and mechanisms involved in mammalian iron metabolism, which is a basis for control of iron toxicity. Such a discussion is intended to facilitate the identification of deficiencies so that future metabolic or toxicological studies may be appropriately focused. A better knowledge of iron metabolism from normal to pathophysiological conditions will ultimately broaden the spectrum of the usefulness of this information in biomedical and toxicological sciences for improving and protecting human health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MAMMALIAN artificial chromosomes
KW - METABOLISM
KW - IRON in the body
KW - IRON metabolism
KW - ABSORPTION
KW - POISONS
KW - OXIDATIVE stress
KW - HEMOCHROMATOSIS
KW - MOLECULES
KW - LIVER
KW - Absorption
KW - Dietary Iron
KW - DMT1
KW - Evidence-Based
KW - Ferritin
KW - Ferroportin
KW - Hemochromatosis
KW - Hepcidin
KW - Iron Metabolism
KW - Iron Overload
KW - Iron Regulatory Protein
KW - Iron Responsive Element
KW - Liver
KW - Molecular Regulation
KW - Oxidative Stress
KW - Toxicity
KW - Transferrin
N1 - Accession Number: 27688818; Valerio Jr., Luis G. 1; Email Address: Luis.Valerio@FDA.HHS.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition,Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, MD 20470, USA; Source Info: Dec2007, Vol. 17 Issue 9, p497; Subject Term: MAMMALIAN artificial chromosomes; Subject Term: METABOLISM; Subject Term: IRON in the body; Subject Term: IRON metabolism; Subject Term: ABSORPTION; Subject Term: POISONS; Subject Term: OXIDATIVE stress; Subject Term: HEMOCHROMATOSIS; Subject Term: MOLECULES; Subject Term: LIVER; Author-Supplied Keyword: Absorption; Author-Supplied Keyword: Dietary Iron; Author-Supplied Keyword: DMT1; Author-Supplied Keyword: Evidence-Based; Author-Supplied Keyword: Ferritin; Author-Supplied Keyword: Ferroportin; Author-Supplied Keyword: Hemochromatosis; Author-Supplied Keyword: Hepcidin; Author-Supplied Keyword: Iron Metabolism; Author-Supplied Keyword: Iron Overload; Author-Supplied Keyword: Iron Regulatory Protein; Author-Supplied Keyword: Iron Responsive Element; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Molecular Regulation; Author-Supplied Keyword: Oxidative Stress; Author-Supplied Keyword: Toxicity; Author-Supplied Keyword: Transferrin; Number of Pages: 21p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1080/15376510701556690
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27688818&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BUEHLER, PAUL W.
AU - ALAYASH, ABDU I.
T1 - Oxidation of hemoglobin: mechanisms of control in vitro and in vivo.
JO - Transfusion Alternatives in Transfusion Medicine
JF - Transfusion Alternatives in Transfusion Medicine
Y1 - 2007/12//
VL - 9
IS - 4
M3 - Article
SP - 204
EP - 212
SN - 12959022
AB - Hemoglobin (Hb) within red blood cells (RBC) is protected from oxidative processes by enzymatic and small molecule antioxidants as well as the RBC membrane that provides a physical barrier against oxidation. When Hb is introduced into the circulation as a result of hemolysis or following infusion of Hb-based oxygen carriers (HBOCs; ‘blood substitutes’), the control of oxidative processes becomes dependent on plasma oxidative status. In vitro studies clearly demonstrate that Hb and HBOCs undergo oxidative modification at the site of heme iron and at multiple amino acid sites as a result of autoxidation, nitrosylation and peroxidation. Recent findings from in vitro studies provide a strong basis for understanding of potential toxicity in vivo. The antioxidative status of both plasma and tissue becomes an important factor in the control of Hb and HBOC oxidation and nitrosylation in the circulation. Several studies that performed ex vivo and in vivo have demonstrated a critical role for plasma antioxidants such as ascorbic acid and uric acid in maintaining Hb and HBOCs in functional non-oxidized states. In the present review we discuss mechanisms of Hb and HBOC autoxidation, nitrosylation and peroxidation in vitro and in vivo. Additionally, we explore the role(s) of plasma antioxidants in maintaining functional HBOC status that may potentially be exploited as part of protective strategies against Hb and HBOC oxidative toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion Alternatives in Transfusion Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATION
KW - HEMOGLOBIN
KW - ERYTHROCYTES
KW - ENZYMATIC analysis
KW - ANTIOXIDANTS
KW - BLOOD circulation
KW - Blood substitutes
KW - Free radicals
KW - Hemoglobin
KW - Oxidation
N1 - Accession Number: 29993588; BUEHLER, PAUL W. 1 ALAYASH, ABDU I. 1; Email Address: abdu.alayash@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, MARYLAND, USA; Source Info: Dec2007, Vol. 9 Issue 4, p204; Subject Term: OXIDATION; Subject Term: HEMOGLOBIN; Subject Term: ERYTHROCYTES; Subject Term: ENZYMATIC analysis; Subject Term: ANTIOXIDANTS; Subject Term: BLOOD circulation; Author-Supplied Keyword: Blood substitutes; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: Oxidation; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1778-428X.2007.00081.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=29993588&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2007-07765-003
AN - 2007-07765-003
AU - Hartley, Tara A.
AU - Violanti, John M.
AU - Fekedulegn, Desta
AU - Andrew, Michael E.
AU - Burchfiel, Cecil M.
T1 - Associations between major life events, traumatic incidents, and depression among Buffalo police officers.
JF - International Journal of Emergency Mental Health
JO - International Journal of Emergency Mental Health
JA - Int J Emerg Ment Health
Y1 - 2007///Win 2007
VL - 9
IS - 1
SP - 25
EP - 35
CY - US
PB - Chevron Publishing
SN - 1522-4821
AD - Hartley, Tara A., Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Willowdale Road, MS 4050, Morgantown, WV, US, 26505
N1 - Accession Number: 2007-07765-003. PMID: 17523373 Other Journal Title: International Journal of Emergency Mental Health and Human Resilience. Partial author list: First Author & Affiliation: Hartley, Tara A.; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: OMICS Group. Release Date: 20070709. Correction Date: 20140728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Emotional Trauma; Life Experiences; Major Depression; Occupational Stress; Police Personnel. Minor Descriptor: Experiences (Events); Law Enforcement; Occupational Exposure; Well Being. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Paykel's Life Events Scale; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Win 2007.
AB - Police officers are considered to be a highly stressed population due to the nature of the work they perform. Repeated exposures to work stress and stressful life events can affect one's psychological and physiological well-being. The objective of this study was to determine whether negative life events and traumatic police incidents are associated with depression in police officers. One hundred randomly selected urban officers completed a series of self-report measures as part of a cross-sectional pilot study. Using four negative life event categories (none, low, medium, and high) a J-shaped pattern was observed with mean depression scores (±SD) of 9.26 (±7.41), 6.21 (±5.94), 8.17 (±7.42), and 14.64 (±8.04), respectively (test for linear trend p = 0.0186). Adjustment for age (p = 0.0209), then age, gender, and ethnicity together (p = 0.0184) did not alter this pattern appreciably. No association between traumatic police incidents and depression was observed. Results indicate that exposure to multiple negative life events is significantly associated with elevated depression scores among this sample. Police agencies should consider developing psychological assistance efforts to help affected officers cope with these events and deal with depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - police officers
KW - negative life events
KW - traumatic incidents
KW - depression
KW - occupational stress
KW - occupational exposure
KW - well-being
KW - 2007
KW - Emotional Trauma
KW - Life Experiences
KW - Major Depression
KW - Occupational Stress
KW - Police Personnel
KW - Experiences (Events)
KW - Law Enforcement
KW - Occupational Exposure
KW - Well Being
KW - 2007
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: HELD01B0088. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-07765-003&site=ehost-live&scope=site
UR - THartley@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01383-004
AN - 2008-01383-004
AU - Wang, Min Qi
AU - Matthew, Resa F.
AU - Chiu, Yu-Wen
AU - Yan, Fang
AU - Bellamy, Nikki D.
T1 - Latent model analysis of substance use and HIV risk behaviors among high-risk minority adults.
JF - Journal of Alcohol and Drug Education
JO - Journal of Alcohol and Drug Education
JA - J Alcohol Drug Educ
Y1 - 2007/12//
VL - 51
IS - 4
SP - 35
EP - 62
CY - US
PB - Journal of Alcohol and Drug Education, Inc.
SN - 0090-1482
SN - 2162-4119
AD - Wang, Min Qi, Department of Public and Community Health, University of Maryland, Suite 2387 Valley Drive, College Park, MD, US, 20742
N1 - Accession Number: 2008-01383-004. Partial author list: First Author & Affiliation: Wang, Min Qi; University of Maryland, College Park, MD, US. Other Publishers: American Alcohol & Drug Information Foundation. Release Date: 20080218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; HIV; Minority Groups; Psychosexual Behavior; Sexual Risk Taking. Classification: Psychological & Physical Disorders (3200); Sexual Behavior & Sexual Orientation (2980). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Adult Baseline Questionnaire; Family Environment Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 28. Issue Publication Date: Dec, 2007.
AB - Objectives: This study evaluated substance use and HIV risk profile using a latent model analysis based on ecological theory, inclusive of a risk and protective factor framework, in sexually active minority adults (N = 1,056) who participated in a federally funded substance abuse and HIV prevention health initiative from 2002 to 2006. Methods: Data were collected locally from community-based organizations using a common baseline instrument that was administered within 30 days of program entry. The latent variables included were social support; neighborhood attachment; family cohesion; intimate abuse; alcohol, tobacco/other drugs (ATOD) use; and HIV risk behaviors. Results: The model-fit indices met acceptable standards for African Americans (CFI = 0.962, TLI = 0.956, RMSEA = 0.033) and for Hispanic/Latinos (CFI = 0.927, TLI = 0.917, RMSEA = 0.047). For African Americans, neighborhood attachment was significantly related to intimate abuse (coefficient = .126, p < .01) and family cohesion (coefficient = .281, p < .01). Social support was not significantly related to either family cohesion or intimate abuse. Family cohesion was negatively related to ATOD use, which was also related to sex with risk partners and drug-related sex. For Hispanics, neighborhood attachment was significantly related to intimate abuse (coefficient = .209, p < .01) and family cohesion (coefficient = .209, p < .01). Social support was significantly related to family cohesion (coefficient = .274, p < .01), but not related to intimate abuse. Intimate abuse was negatively related to ATOD use. Conclusions: The results support the inclusion of protective factors as a standard implementation approach for prevention programs targeted to the reduction of ATOD use and HIV risk among sexually active minority adults. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance use
KW - HIV risk behaviors
KW - minority adults
KW - sexual behavior
KW - 2007
KW - Drug Abuse
KW - HIV
KW - Minority Groups
KW - Psychosexual Behavior
KW - Sexual Risk Taking
KW - 2007
U1 - Sponsor: Center for Substance Abuse Prevention. Grant: 277-00-6207. Other Details: ORC Macro International. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01383-004&site=ehost-live&scope=site
UR - mqw@umd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00873-012
AN - 2008-00873-012
AU - Kane, Rosalie A.
AU - Wilson, Keren Brown
AU - Spector, William
T1 - Developing a research agenda for assisted living.
T3 - Improving practice through research in and bbout assisted living: Implications for a research agenda
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2007/12//
VL - 47
IS - Spec Issue 3
SP - 141
EP - 154
CY - US
PB - Gerontological Society of America
SN - 0016-9013
SN - 1758-5341
AD - Kane, Rosalie A., Division of Health Policy and Management, School of Public Health, University of Minnesota, 420 Delaware Street SE, MMC 197, Minneapolis, MN, US, 55408
N1 - Accession Number: 2008-00873-012. Partial author list: First Author & Affiliation: Kane, Rosalie A.; Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN, US. Other Publishers: Oxford University Press. Release Date: 20080825. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Assisted Living; Consumer Behavior; Decision Making; Experimentation. Classification: Research Methods & Experimental Design (2260); Nursing Homes & Residential Care (3377). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 14. Issue Publication Date: Dec, 2007.
AB - Purpose: We describe an approach to identifying knowledge gaps, research questions, and methodological issues for assisted living (AL) research. Design and Methods: We undertook an inventory of AL literature and research in progress and commissioned background papers critiquing knowledge on selected subtopics. With an advisory committee, we identified a comprehensive list of researchable questions of potential utility to consumers, providers, and/or policy makers, which AL researchers then rated as to their importance. The preliminary work facilitated a structured working conference of AL researchers. Results: The top five priority topics identified as a result of the polling before the conference were consumer preferences, cost and financing, developing an information system for consumer decision making, developing quality measures, and resident outcomes. From conference discussion, conferees added other emphasis areas and refined the original ones. They flagged lack of standardized definitions and measures as barriers to building an empirically based AL literature. Conferees also identified distinctions between research on AL as a whole and research on interventions within AL. Implications: In an emerging area in which the literature cannot yet support rigorous comparisons, meta-analysis, or consensus conferences, the systematic approaches, including assembling researchers who use widely different methods, generated substantial agreement on a research agenda. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - developing research agenda
KW - assisted living
KW - consumer preferences
KW - consumer decision making
KW - 2007
KW - Assisted Living
KW - Consumer Behavior
KW - Decision Making
KW - Experimentation
KW - 2007
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 1R13HSO14027-01. Date: from Jul 01, 2003 to Jun 30, 2005. Other Details: Conference Grant. Recipients: No recipient indicated
U1 - Sponsor: Minnesota Department of Human Services, US. Other Details: Department from the Bush Foundation. Recipients: No recipient indicated
U1 - Sponsor: University of Minnesota, Chair in Long- Term Care and Aging, US. Recipients: No recipient indicated
U1 - Sponsor: AARP Public Policy Institute. Recipients: No recipient indicated
DO - 10.1093/geront/47.Supplement_1.141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00873-012&site=ehost-live&scope=site
UR - kanex002@umn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18257-005
AN - 2007-18257-005
AU - Tiesman, Hope M.
AU - Peek-Asa, Corinne L.
AU - Zwerling, Craig S.
AU - Sprince, Nancy L.
AU - Amoroso, Paul J.
T1 - Occupational and non-occupational injuries in the United States Army: Focus on gender.
T3 - Timing of repeat colonoscopy disparity between guidelines and endoscopists' recommendation
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2007/12//
VL - 33
IS - 6
SP - 464
EP - 470
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Tiesman, Hope M., NIOSH, Division of Safety Research, 1095 Willowdale Road M/S 1811, Morgantown, WV, US, 26505
N1 - Accession Number: 2007-18257-005. PMID: 18022062 Partial author list: First Author & Affiliation: Tiesman, Hope M.; National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, US. Release Date: 20080218. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Army Personnel; Human Sex Differences; Injuries; Work Related Illnesses. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2007.
AB - Background: The differences in occupational and non-occupational injuries between military men and women have not been documented. This study compares occupational and non-occupational injuries between male and female United States Army soldiers by examining injury hospitalization rates and characteristics. Methods: The U.S. Army's Total Army Injury and Health Outcomes Database was searched for hospitalizations with ICD-9-CM codes for injury (800-959.9) between 1992 and 2002. Injury rates were calculated using yearly U.S. Army population data and compared using rate ratios. Injury characteristics were compared among categories of the Trauma Code (on duty; off duty; scheduled training, schemes, and exercises), stratified by gender. Results: Included in this analysis were 792 women for an injury hospitalization rate of 11.0 per 1000 individuals (95% confidence interval [CI] = 8.5-13.5) and 4879 men for a rate of 15.5 per 1000 individuals (95% CI = 14.0-16.9). While women had significantly more injuries during scheduled training, schemes, and exercises than men (p < 0.0001), there were few differences in the cause of those injuries. Women had longer average hospital stays compared to men due to these injuries (9.3 days vs 7.4 days, p = 0.002), although these injuries were not more severe (average Injury Severity Score=3.5 for men vs average ISS for women=3.5, p = 0.79). There was no difference between the genders in the percent of injuries that occurred off duty; however, men were more likely to get injured due to sports and athletics (p = 0.001) and due to fighting (p = 0.017) while off duty compared to women. Conclusions: Injury prevention messages for military personnel should focus on reducing risk factors for both on- and off-duty injuries. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - occupational injuries
KW - non-occupational injuries
KW - US army
KW - gender differences
KW - 2007
KW - Army Personnel
KW - Human Sex Differences
KW - Injuries
KW - Work Related Illnesses
KW - 2007
U1 - Sponsor: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Grant: CCR 703640. Other Details: University of Iowa Injury Prevention Research Center. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Heartland Center for Occupational Health and Safety Occupational Injury Prevention Program. Grant: T42/CCT717547. Other Details: Pilot project. Recipients: No recipient indicated
U1 - Sponsor: University of Iowa, Department of Occupational and Environmental Health, US. Recipients: No recipient indicated
DO - 10.1016/j.amepre.2007.07.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18257-005&site=ehost-live&scope=site
UR - htiesman@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08354-004
AN - 2008-08354-004
AU - Malik, Tahir
AU - Sauder, Christian
AU - Wolbert, Candie
AU - Zhang, Cheryl
AU - Carbone, Kathryn M.
AU - Rubin, Steven
T1 - A single nucleotide change in the mumps virus F gene affects virus fusogenicity in vitro and virulence in vivo.
JF - Journal of Neurovirology
JO - Journal of Neurovirology
JA - J Neurovirol
Y1 - 2007/12//
VL - 13
IS - 6
SP - 513
EP - 521
CY - United Kingdom
PB - Taylor & Francis
SN - 1355-0284
SN - 1538-2443
AD - Malik, Tahir, DVP/Office of Vaccines Research and Review, Center for Biologies Evaluation and Research, Food and Drug Administration, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-08354-004. PMID: 18097883 Partial author list: First Author & Affiliation: Malik, Tahir; DVP/Office of Vaccines Research and Review, Center for Biologies Evaluation and Research, Food and Drug Administration, Bethesda, MD, US. Other Publishers: Informa Healthcare; Springer. Release Date: 20081006. Correction Date: 20110110. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Sauder, Christian. Major Descriptor: DNA; Genes; Infectious Disorders; Nucleotides; Polymorphism. Classification: Genetics (2510); Immunological Disorders (3291). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2007.
AB - Mumps virus is highly neurotropic, with evidence of infection of the central nervous system in more than half of clinical cases. In the prevaccine era, mumps was a major cause of viral meningitis in most developed countries. Despite efforts to attenuate the virus, some mumps vaccines have retained virulence properties and have caused aseptic meningitis in vaccinees, resulting in public resistance to vaccination in some countries. Ensuring the safety of mumps vaccines is an important public health objective, as the need for robust immunization programs has been made clear by the recent resurgence of mumps outbreaks worldwide, including the United States, which in 2006 experienced its largest mumps outbreak in 20 years. To better understand the molecular basis of mumps virus attenuation, the authors developed two infectious full-length cDNA clones for a highly neurovirulent strain of mumps virus. The clones differed at only one site, possessing either an A or G at nucleotide position 271 in the F gene, to represent the heterogeneity identified in the original virulent clinical isolate. In comparison to the clinical isolate, virus rescued from the A-variant cDNA clone grew to higher cumulative titers in vitro but exhibited similar cytopathic effects in vitro and virulence in vivo. In contrast, virus rescued from the G-variant cDNA clone, in comparison to the clinical isolate and the A-variant, was more fusogenic in vitro but replicated to lower cumulative titers and was less neurovirulent in vivo. These data suggest that nucleotide position 271 in the F gene plays a significant role in virus pathogenesis. This infectious clone system will serve as a key tool for further examination of the molecular basis for mumps virus neurovirulence and neuroattenuation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - single nucleotide change
KW - mumps virus
KW - F gene
KW - virus fusogenicity
KW - virus virulence
KW - viral infections
KW - 2007
KW - DNA
KW - Genes
KW - Infectious Disorders
KW - Nucleotides
KW - Polymorphism
KW - 2007
U1 - Sponsor: Oak Ridge Institute for Science and Education. Other Details: Through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration.. Recipients: Sauder, Christian; Wolbert, Candie
DO - 10.1080/13550280701658382
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08354-004&site=ehost-live&scope=site
UR - christian.sauder@fda.hhs.gov
UR - tahir.malik@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18077-005
AN - 2007-18077-005
AU - Palinkas, Lawrence A.
AU - Reedy, Kathleen R.
AU - Shepanek, Marc
AU - Smith, Mark
AU - Anghel, Mihai
AU - Steel, Gary D.
AU - Reeves, Dennis
AU - Case, H. Samuel
AU - Van Do, Nhan
AU - Reed, H. Lester
T1 - Environmental influences on hypothalamic-pituitary-thyroid function and behavior in Antarctica.
JF - Physiology & Behavior
JO - Physiology & Behavior
JA - Physiol Behav
Y1 - 2007/12//
VL - 92
IS - 5
SP - 790
EP - 799
CY - Netherlands
PB - Elsevier Science
SN - 0031-9384
AD - Palinkas, Lawrence A., School of Social Work, University of Southern California, 669 W. 34th Street, Los Angeles, CA, US, 90089-0411
N1 - Accession Number: 2007-18077-005. PMID: 17628620 Partial author list: First Author & Affiliation: Palinkas, Lawrence A.; School of Social Work, University of Southern California, Los Angeles, CA, US. Release Date: 20071210. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Environmental Effects; Hypothalamic Pituitary Adrenal Axis; Physiological Psychology; Thyroid Hormones. Classification: Genetics (2510). Population: Human (10); Male (30); Female (40). Location: Antarctica. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340). Tests & Measures: Automated Neuropsychological Assessment Metric for Isolated and Confined Environments. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2007.
AB - We examined the physiological and psychological status of men and women who spent the summer (n = 100) and/or winter (n = 85) seasons in Antarctica at McMurdo (latitude 78.48 S, elevation 12 m) and South Pole (latitude 90 S, elevation 3880 m) stations to determine whether there were any significant differences by severity of the stations' physical environment. Physiological measures (body mass index, blood pressure, heart rate, tympanic temperature), serum measures of thyroid hormones, cortisol, and lipids and plasma catecholamines were obtained at predeployment (Sep-Oct) and the beginning of the summer (November) and winter (Mar-Apr) seasons. Cognitive performance and mood were assessed using the Automatic Neuropsychological Assessment Metric--Isolated and Confined Environments (ANAM-ICE), a computerized test battery. South Pole residents had a lower body mass index (p < 0.05) and body temperature (p < 0.01) and higher levels of plasma norepinephrine (p < 0.05) in summer and winter than McMurdo residents. Upon deployment from the United States and during the summer, South Pole residents experienced significantly higher thyroid hormone values (free and total T3 and T4) (p < 0.01) than McMurdo residents; in summer they also experienced lower levels of triglycerides (p < 0.01) cortisol (p < 0.05) and LDL (p < 0.05). In winter, South Pole residents also experienced a 39% decrease in serum TSH compared with a 31.9% increase in McMurdo (p < 0.05). South Pole residents also were significantly more accurate (p < 0.05) and efficient (p < 0.01) in performance of complex cognitive tasks in summer and winter. Higher thyroid hormone levels, combined with lower BMI and body temperature, may reflect increased metabolic and physiological responses to colder temperatures and/or higher altitude at South Pole with no apparent adverse effect on mood and cognition. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - environmental influences
KW - hypothalamic-pituitary-thyroid
KW - physiological status
KW - psychological status
KW - 2007
KW - Environmental Effects
KW - Hypothalamic Pituitary Adrenal Axis
KW - Physiological Psychology
KW - Thyroid Hormones
KW - 2007
U1 - Sponsor: National Science Foundation. Grant: OPP-0090343. Recipients: No recipient indicated
DO - 10.1016/j.physbeh.2007.06.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18077-005&site=ehost-live&scope=site
UR - palinkas@usc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19640-004
AN - 2007-19640-004
AU - Young, Johnny
T1 - Identity as subterfuge: A Kleinian and Winnicottian reading of David Lynch's Mulholland Drive.
T3 - On film
JF - Psychoanalytic Review
JO - Psychoanalytic Review
JA - Psychoanal Rev
Y1 - 2007/12//
VL - 94
IS - 6
SP - 903
EP - 925
CY - US
PB - Guilford Publications
SN - 0033-2836
AD - Young, Johnny, 1702 Sage Brook Court, Severn, MD, US, 21144-1058
N1 - Accession Number: 2007-19640-004. PMID: 18081468 Other Journal Title: Psychoanalysis & the Psychoanalytic Review. Partial author list: First Author & Affiliation: Young, Johnny; Food and Drug Administration, Office of Generic Drugs, Washington, DC, US. Release Date: 20080211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amnesia; Films; Motor Traffic Accidents; Paranoia; Psychoanalytic Interpretation. Classification: Psychoanalytic Theory (3143); Literature & Fine Arts (2610). Population: Human (10). References Available: Y. Page Count: 23. Issue Publication Date: Dec, 2007.
AB - Analyzes the film, Mulholland Drive. The film is challenging and complex, as unsettling as it is fascinating. The first half follows an ostensibly linear trajectory detailing the plight of a woman who has suffered amnesia as a result of a horrific car accident and that of the young ingenue who befriends her. The development of their odd relationship drives the narrative, which becomes progressively amorphous as it spirals into a pit of duality, paranoia, and death. Mulholland Drive is a brilliant interplay of four voices issuing from the depths of one person's bleak despair. My reading is by no means an authoritative interpretation, but rather an alternative one, likened to the unique perspective as seen by one of several painters seated around a common subject. That Lynch's work should provoke such varied discussion and contemplation is a testament to his profound and inimitable artistry. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Mulholland Drive
KW - amnesia
KW - car accident
KW - 2007
KW - Amnesia
KW - Films
KW - Motor Traffic Accidents
KW - Paranoia
KW - Psychoanalytic Interpretation
KW - 2007
DO - 10.1521/prev.2007.94.6.903
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19640-004&site=ehost-live&scope=site
UR - davidmountolive@cablespeed.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-17757-008
AN - 2007-17757-008
AU - Dechartres, Agnès
AU - Mazeau, Valérie
AU - Grenier-Sennelier, Catherine
AU - Brézin, Antoine P.
AU - Vidal-Trecan, Gwenaelle M.
T1 - Improving the organization of consultation departments in university hospitals.
JF - Journal of Evaluation in Clinical Practice
JO - Journal of Evaluation in Clinical Practice
JA - J Eval Clin Pract
Y1 - 2007/12//
VL - 13
IS - 6
SP - 930
EP - 934
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1356-1294
SN - 1365-2753
AD - Vidal-Trecan, Gwenaelle M., Service de Sante Publique Hopital Cochin, 27 rue du Faubourg St Jacques, 75679, Paris, France, Cedex 14
N1 - Accession Number: 2007-17757-008. PMID: 18070264 Partial author list: First Author & Affiliation: Dechartres, Agnès; Service de Sante Publique, Groupe Hospitalier Cochin Saint Vincent de Paul, Paris, France. Other Publishers: Blackwell Publishing. Release Date: 20080317. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Hospitals; Ophthalmology; Physicians; Work Load. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Location: France. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Dec, 2007.
AB - Rationale: Changes in the demography of doctors require changes in care practices. Objectives: The aim of this study was to identify factors associated with doctors' workload in the ophthalmology consultation department of a university hospital, with a view to developing methods to improve the organization of hospital outpatient clinics. Methods: A 10-day cross-sectional survey was carried out in an ophthalmology outpatient clinic (in- and outpatient consultations, including emergencies) specializing in the uveitis care. Demographic and management data for each patient were collected on a structured form. The doctor's workload was assessed, using a scale taking into account the duration of the consultation and the number of diagnostic tests performed, as a function of management complexity. Results: Of the 861 consultations studied, 39.7% were highly complex. The level of complexity of consultations was correlated with the type of referral (phi = 0.602), consultation duration (phi = 0.545), the number of consultations in the previous year (phi = 0.499), and the number of diagnostic tests performed (phi = 0.445). Consultations were longer and diagnostic tests were more frequently performed if patients had been referred by an ophthalmologist, consulted a faculty doctor or a fellow, or presented with uveitis. Consultations were also more complex for patients with at least four previous consultations in the past year. Conclusions: Type of referral, status of the attending doctor and number of consultations within the course of 1 year were associated with doctors' workload and could be taken into account to predict the duration of complexity of consultations when scheduling appointments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workload
KW - doctors in ophthalmology consultation department
KW - university hospitals
KW - demographics
KW - 2007
KW - Demographic Characteristics
KW - Hospitals
KW - Ophthalmology
KW - Physicians
KW - Work Load
KW - 2007
DO - 10.1111/j.1365-2753.2006.00785.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-17757-008&site=ehost-live&scope=site
UR - ORCID: 0000-0002-2010-0207
UR -
UR - gwenaelle.vidal-trecan@cochin.univparis5.fr
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19974-001
AN - 2007-19974-001
AU - Cawley, John
AU - Meyerhoefer, Chad
AU - Newhouse, David
T1 - The impact of state physical education requirements on youth physical activity and overweight.
JF - Health Economics
JO - Health Economics
JA - Health Econ
Y1 - 2007/12//
VL - 16
IS - 12
SP - 1287
EP - 1301
CY - US
PB - John Wiley & Sons
SN - 1057-9230
SN - 1099-1050
AD - Cawley, John, Department of Policy Analysis and Management, Cornell University, 124 MVR Hall, Ithaca, NY, US, 14853
N1 - Accession Number: 2007-19974-001. PMID: 17328052 Partial author list: First Author & Affiliation: Cawley, John; Cornell University, Ithaca, NY, US. Release Date: 20080825. Correction Date: 20130114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Exercise; Overweight; Physical Activity; Physical Education. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Dec, 2007.
AB - To combat childhood overweight in the US, which has risen dramatically in the past three decades, many medical and public health organizations have called for students to spend more time in physical education (PE) classes. This paper is the first to examine the impact of state PE requirements on student PE exercise time. It also exploits variation in state laws as quasi-natural experiments in order to estimate the causal impact of PE on overall student physical activity and weight. We study nationwide data from the Youth Risk Behavior Surveillance System for 1999, 2001, and 2003 merged with data on state minimum PE requirements from the 2001 Shape of the Nation Report. We find that high school students with a binding PE requirement report an average of 31 additional minutes per week spent physically active in PE class. Our results also indicate that additional PE time raises the number of days per week that girls report having exercised vigorously or having engaged in strength-building activity. We find no evidence that PE lowers BMI or the probability that a student is overweight. We conclude that raising PE credit requirements may make girls more physically active overall but there is not yet the scientific base to declare raising PE requirements an anti-obesity initiative for either boys or girls. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - physical education
KW - youth physical activity
KW - overweight
KW - exercise
KW - 2007
KW - Exercise
KW - Overweight
KW - Physical Activity
KW - Physical Education
KW - 2007
DO - 10.1002/hec.1218
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19974-001&site=ehost-live&scope=site
UR - JHC38@cornell.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-10374-009
AN - 2008-10374-009
AU - Morabito, Melissa Schaefer
T1 - Horizons of context: Understanding the police decision to arrest people with mental illness.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2007/12//
VL - 58
IS - 12
SP - 1582
EP - 1587
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Morabito, Melissa Schaefer, University of Pennsylvania, School of Social Policy and Practice, 3815 Walnut St., Philadelphia, PA, US, 19104
N1 - Accession Number: 2008-10374-009. PMID: 18048560 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Morabito, Melissa Schaefer; Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20080901. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Behavior; Criminal Justice; Deinstitutionalization; Mental Disorders; Mental Health Services. Minor Descriptor: Decision Making; Police Personnel. Classification: Criminal Behavior & Juvenile Delinquency (3236); Criminal Law & Adjudication (4230). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2007.
AB - The criminalization hypothesis assumes that deinstitutionalization coupled with inadequate police training has led to the increased arrest of people with mental illness. Arrest is viewed as a means to manage the troublesome behavior that often results from mental illness. Supporting research has emphasized the contributing role that illness plays in the arrest decision. This assumption largely ignores an extant criminal justice literature on the factors that influence arrest. On the basis of a review of this criminal justice literature, beginning with Bittner's 1967 seminal work, a framework is proposed that incorporates three contexts--manipulative, temporal, and scenic--surrounding the police encounter and the relationship of these contexts to mental illness. These three 'horizons' incorporate the characteristics of the community, the offender, and the incident, all of which are recognized as influential in shaping police discretion. The scenic horizon is indicative of the features of the community. The temporal horizon includes police knowledge that stretches beyond the specific incident and officer characteristics. The manipulative horizon involves the current incident from the standpoint of the officer and includes considerations of safety for the community as well as the immediate concerns of the officer. Implications of this framework are then explored with respect to both police and mental health service mandates. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - police decision
KW - mental illness
KW - criminalization
KW - criminal justice
KW - mental health services
KW - deinstitutionalization
KW - 2007
KW - Criminal Behavior
KW - Criminal Justice
KW - Deinstitutionalization
KW - Mental Disorders
KW - Mental Health Services
KW - Decision Making
KW - Police Personnel
KW - 2007
U1 - Sponsor: Center for Mental Health Services and Criminal Justice Research. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20-068170; T32-MH070313. Recipients: No recipient indicated
DO - 10.1176/appi.ps.58.12.1582
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10374-009&site=ehost-live&scope=site
UR - melisj@sp2.upenn.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19802-006
AN - 2007-19802-006
AU - Lowery, Elizabeth P.
AU - Henneberger, Paul K.
AU - Rosiello, Richard
AU - Sama, Susan R.
AU - Preusse, Peggy
AU - Milton, Don K.
T1 - Quality of life of adults with workplace exacerbation of asthma.
JF - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JO - Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care & Rehabilitation
JA - Qual Life Res
Y1 - 2007/12//
VL - 16
IS - 10
SP - 1605
EP - 1613
CY - Germany
PB - Springer
SN - 0962-9343
SN - 1573-2649
AD - Henneberger, Paul K., Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US
N1 - Accession Number: 2007-19802-006. PMID: 17957494 Partial author list: First Author & Affiliation: Lowery, Elizabeth P.; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Release Date: 20080128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Asthma; Quality of Life; Working Conditions. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Marks Asthma Quality of Life Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2007.
AB - Objective: A cross-sectional study collecting demographic, work history, disease, and quality-of-life (QOL) data from adults with asthma was explored for a relationship between workplace exacerbation of asthma (WEA) and QOL. Study design and setting: The study population of adults with asthma was drawn from adults affiliated with Fallon Community Health Plan, a health maintenance organization serving Massachusetts. Results: The sample consisted of 598 adults with asthma. Based on univariate analyses, study participants with WEA had a statistically significant higher Total QOL score, indicating a worse quality of life, than participants whose asthma was not work-related (2.43 vs. 1.74, P ≤ 0.001), and also higher scores on the instrument's four subscales for Breathlessness, Mood Disturbance, Social Disruptions, and Health Concerns. After controlling for covariates using multiple linear regression, the relationship between WEA and the Total QOL score was statistically significant (P = 0.0004) with a coefficient of 0.54. The coefficient for WEA was also statistically significant based on regression models for all the subscales with the exception of the Breathlessness score (P = 0.08). Conclusion: In summary, WEA was associated with a worse QOL. Ideally, employees and employers would work together to minimize the conditions at work that contribute to WEA, which should decrease the frequency of WEA and related degradation of QOL. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality of life
KW - workplace exacerbation
KW - asthma
KW - 2007
KW - Asthma
KW - Quality of Life
KW - Working Conditions
KW - 2007
DO - 10.1007/s11136-007-9274-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19802-006&site=ehost-live&scope=site
UR - pkh0@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-25246-002
AN - 2010-25246-002
AU - Gilhooly, C. H.
AU - Das, S. K.
AU - Golden, J. K.
AU - McCrory, M. A.
AU - Dallal, G. E.
AU - Saltzman, E.
AU - Kramer, F. M.
AU - Roberts, S. B.
T1 - Food cravings and energy regulation: The characteristics of craved foods and their relationship with eating behaviors and weight change during 6 months of dietary energy restriction.
JF - International Journal of Obesity
JO - International Journal of Obesity
JA - Int J Obes (Lond)
Y1 - 2007/12//
VL - 31
IS - 12
SP - 1849
EP - 1858
CY - United Kingdom
PB - Nature Publishing Group
SN - 0307-0565
SN - 1476-5497
AD - Roberts, S. B., Energy Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Room 1312, 711 Washington Street, Boston, MA, US, 02111
N1 - Accession Number: 2010-25246-002. PMID: 17593902 Partial author list: First Author & Affiliation: Gilhooly, C. H.; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, US. Release Date: 20110207. Correction Date: 20130415. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; Craving; Diets; Eating Behavior; Food Intake. Minor Descriptor: Energy Expenditure. Classification: Physiological Processes (2540). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Eating Inventory DOI: 10.1037/t15085-000; Craving Questionnaire DOI: 10.1037/t12184-000. Methodology: Clinical Trial; Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2007. Publication History: First Posted Date: Jun 26, 2007; Accepted Date: May 25, 2007; Revised Date: May 7, 2007; First Submitted Date: Oct 14, 2006. Copyright Statement: All rights reserved. Nature Publishing Group. 2007.
AB - Objective: To examine characteristics of craved foods in relation to dietary energy restriction (ER) with high (HG) and low glycemic load (LG) diets. Design: Assessments of food cravings before and during a randomized controlled trial of HG and LG diets provided for 6 months. Subjects: Thirty-two healthy, overweight women aged 20-42 years. Measurements: Self-reported food cravings and dietary intake, body weight, weight history and measures of eating behaviors. Results: Foods craved at baseline were more than twice as high in energy density as the habitual diet (3.7 ± 1.5 vs 1.7±0.3 kcal/g; P < 0.001), and on average were lower in protein (P < 0.001) and fiber (P < 0.001) and higher in fat (P = 0.002). There were no statistically significant changes in nutritional characteristics of craved foods after 6 months of ER. There was a significant relationship between reported portion size of craved food consumed at baseline and lifetime high body mass index (r = 0.49, P = 0.005). Additionally, there was a significant association between susceptibility to hunger and craving frequency at baseline, and there were significant relationships between hunger score, craving frequency, strength and percentage of time that cravings are given in to after 6 months of ER. In multiple regression models, subjects who lost a greater percentage of weight craved higher energy-dense foods at month 6 of ER, but also reported giving in to food cravings less frequently (adjusted R² = 0.31, P = 0.009). Conclusion: High energy density and fat content, and low protein and fiber contents were identifying characteristics of craved foods. The relationships between craving variables and hunger score suggest that the relative influence of hunger susceptibility on cravings may be important before and especially after ER. Portion size of craved foods and frequency of giving in to food cravings appear to be important areas for focus in lifestyle modification programs for long-term weight loss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - food cravings
KW - energy regulation
KW - eating behavior
KW - weight changes
KW - dietary energy restrictions
KW - high & low glycemic load diets
KW - 2007
KW - Body Weight
KW - Craving
KW - Diets
KW - Eating Behavior
KW - Food Intake
KW - Energy Expenditure
KW - 2007
U1 - Sponsor: National Institutes of Health, US. Grant: U01-AG20480. Recipients: No recipient indicated
U1 - Sponsor: US Department of Agriculture, US. Grant: 58-1950-4-401. Recipients: No recipient indicated
U1 - Sponsor: Boston Obesity Nutrition Research Center, US. Grant: H150001. Recipients: No recipient indicated
DO - 10.1038/sj.ijo.0803672
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-25246-002&site=ehost-live&scope=site
UR - susan.roberts@tufts.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18633-014
AN - 2007-18633-014
AU - Herman-Stahl, Mindy
AU - Ashley, Olivia Silber
AU - Penne, Michael A.
AU - Bauman, Karl E.
AU - Weitzenkamp, David
AU - Aldridge, Molly
AU - Gfroerer, Joseph C.
T1 - Serious psychological distress among parenting and nonparenting adults.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/12//
VL - 97
IS - 12
SP - 2222
EP - 2229
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Herman-Stahl, Mindy, RTI International, PO Box 12149, Research Triangle Park, NC, US, 27709-2149
N1 - Accession Number: 2007-18633-014. PMID: 17971564 Partial author list: First Author & Affiliation: Herman-Stahl, Mindy; RTI International, Research Triangle Park, NC, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Distress; Health Care Services; Parenting Skills; Quality of Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2007.
AB - Objectives: We compared the prevalence of serious psychological distress among parenting adults with the prevalence among nonparenting adults and the sociodemographic correlates of serious psychological distress between these 2 populations. Methods: We drew data from 14240 parenting adults and 19224 nonparenting adults who responded to the 2002 National Survey on Drug Use and Health. We used logistic regression procedures in our analysis. Results: An estimated 8.9% of parenting adults had serious psychological distress in the prior year compared with 12.0% of nonparenting adults of similar age. In both groups, the adjusted odds of having serious psychological distress were higher among adults who were women, younger (between the ages of 18 and 44 years), low income, or receiving Medicaid. We found some differences in the correlates of serious psychological distress between parenting adults and nonparenting adults. The odds of having serious psychological distress were lower among parenting adults after we controlled for demographic characteristics. Conclusions: Serious psychological distress is fairly prevalent among parenting adults, and high-risk sociodemographic groups of parenting adults should be targeted to ensure access to coordination of services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serious psychological distress
KW - parenting skills
KW - quality of services
KW - health care services
KW - 2007
KW - Distress
KW - Health Care Services
KW - Parenting Skills
KW - Quality of Services
KW - 2007
DO - 10.2105/AJPH.2005.081109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18633-014&site=ehost-live&scope=site
UR - mindy@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-18633-021
AN - 2007-18633-021
AU - Siahpush, Mohammad
AU - Spittal, Matt
AU - Singh, Gopal K.
T1 - Association of smoking cessation with financial stress and material well-being: Results from a prospective study of a population-based national survey.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2007/12//
VL - 97
IS - 12
SP - 2281
EP - 2287
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Siahpush, Mohammad, Department of Health Promotion, Social and Behavioral Health Sciences, College of Public Health, University of Nebraska Medical Center, 986075, Omaha, NE, US, 68198-6075
N1 - Accession Number: 2007-18633-021. PMID: 17971550 Partial author list: First Author & Affiliation: Siahpush, Mohammad; Centre for Behavioural Research in Cancer, Cancer Council Victoria, VIC, Australia. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Siahpush, Mohammad. Major Descriptor: Financial Strain; Smoking Cessation; Tobacco Smoking; Well Being. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2007.
AB - Objectives: We used 4 waves of prospective data to examine the association of smoking cessation with financial stress and material well-being. Methods: Data (n = 5699 at baseline) came from 4 consecutive waves (2001-2005) of the Household Income and Labour Dynamics in Australia survey. We used mixed models to examine the participant-specific association of smoking cessation with financial stress and material well-being. Results: On average, a smoker who quits is expected to have a 25% reduction (P < .001; odds ratio [OR] = 0.75; 95% confidence interaval [CI] = 0.69, 0.81) in the odds of financial stress. Similarly, the data provided strong evidence (P < .001) that a smoker who quits is likely to experience an enhanced level of material well-being. Conclusions: Our findings indicate that interventions to encourage smoking cessation are likely to improve standards of living and reduce deprivation. The findings provide grounds for encouraging the social services sector to incorporate smoking cessation efforts into their programs to enhance the material or financial conditions of disadvantaged groups. The findings also provide additional incentives for smokers to stop smoking and as such can be used in antismoking campaigns and by smoking cessation services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking cessation
KW - financial stress
KW - material well being
KW - antismoking campaigns
KW - 2007
KW - Financial Strain
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Well Being
KW - 2007
U1 - Sponsor: Victorian Health Promotion Foundation, Australia. Recipients: Siahpush, Mohammad
U1 - Sponsor: Department of Family and Community Services (FaCS), Australia. Other Details: Household Income and Labour Dynamics in Australia survey. Recipients: No recipient indicated
DO - 10.2105/AJPH.2006.103580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-18633-021&site=ehost-live&scope=site
UR - msiahpush@unmc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Steven Cohen
AU - Diane Makuc
AU - Trena Ezzati-Rice
T1 - Health insurance coverage during a 24-month period: a comparison of estimates from two national health surveys.
JO - Health Services & Outcomes Research Methodology
JF - Health Services & Outcomes Research Methodology
Y1 - 2007/12/03/
VL - 7
IS - 3/4
M3 - Article
SP - 125
EP - 144
SN - 13873741
AB - Abstract  National estimates of the uninsured are available from multiple surveys and differ across surveys. Previous efforts to better understand reasons for differences among these estimates have primarily focused on annual estimates. This study compares national estimates of health insurance coverage over generally comparable 24-month time periods using two integrated Federal health-related surveys, the Medical Expenditure Panel Survey (MEPS) and the National Health Interview Survey (NHIS) for the years 2002â2003 and replicated analyses for 2001â2002. We examine survey participants insurance status in year 1 and year 2 based on the NHIS linked with the MEPS and also for MEPS year 1 and year 2 participants. We also examine characteristics associated with 24-month coverage status. National estimates of the percents continuously insured did not differ significantly between the two data sources. In contrast, the MEPS longitudinal estimate of the percent continuously uninsured was higher than the NHIS-MEPS linked estimate whereas the MEPS longitudinal estimate of the discontinuously insured was lower than that derived from the NHIS-MEPS linked data. Factors that help explain these differences include the non-equivalence of the time periods covered by the data sources, modest differences in the length of time covered by the MEPS and NHIS survey instruments, and length of recall. Regression analyses yielded highly consistent correlates of being continuously uninsured versus continuously insured for both data sources. Regression results for discontinuous versus continuous coverage were also generally similar for both data sources. Gaining a better understanding of the alignment in findings based on alternative data sources that support comparable analyses of health insurance coverage helps policymakers to make the most appropriate use of resultant estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services & Outcomes Research Methodology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE
KW - CONFERENCES & conventions
KW - MULTIPLE-line insurance
KW - REGRESSION analysis
N1 - Accession Number: 27413581; Steven Cohen 1 Diane Makuc 2 Trena Ezzati-Rice 1; Affiliation: 1: Agency for Healthcare Research and Quality 540 Gaither Road John M. Eisenberg Building Rockville MD 20850 USA 2: Centers for Disease Control and Prevention (CDC)/National Center for Health Statistics 3311 Toledo Rd Hyattsville MD 20782 USA; Source Info: Dec2007, Vol. 7 Issue 3/4, p125; Subject Term: INSURANCE; Subject Term: CONFERENCES & conventions; Subject Term: MULTIPLE-line insurance; Subject Term: REGRESSION analysis; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; Number of Pages: 20p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hargan, Eric
AU - O'Brien, Daniel
AU - Sherman, Susan
AU - Benjamin, Georges
T1 - Vaccine Law 101.
JO - Journal of Law, Medicine & Ethics
JF - Journal of Law, Medicine & Ethics
Y1 - 2007/12/03/Dec2007 Supplement 4
VL - 35
M3 - Article
SP - 72
EP - 76
PB - Wiley-Blackwell
SN - 10731105
AB - The article focuses on the laws on vaccination in the United States, as discussed by Georges Benjamin, Susan Sherman, and Daniel O'Brien. Benjamin stated that vaccination programs are seen as one accomplishment by the state. Sherman discusses the statutes of the U.S. Department of Health and Human Services on vaccination programs. O'Brien agreed that global campaigns on smallpox, and polio vaccination has been one of the greatest endeavors of public health.
KW - VACCINATION
KW - GOVERNMENT policy
KW - PREVENTIVE medicine -- Law & legislation
KW - HEALTH promotion
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 27974254; Hargan, Eric 1 O'Brien, Daniel 2 Sherman, Susan 3 Benjamin, Georges 4; Affiliation: 1: Principal Deputy Associate Secretary U.S. Department of Health and Human Services 2: Public Health Service Office of the Maryland Attorney General 3: Senior Attorney OGC, DHHS 4: Executive Director American Public Health Association; Source Info: Dec2007 Supplement 4, Vol. 35, p72; Subject Term: VACCINATION; Subject Term: GOVERNMENT policy; Subject Term: PREVENTIVE medicine -- Law & legislation; Subject Term: HEALTH promotion; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1748-720X.2007.00215.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Casciotti, John
AU - Ryan, Cynthia
AU - Sienko, Dean Gerald
AU - Williams, Robert C.
T1 - Law at the Intersection of Civilian and Military Public Health Practice.
JO - Journal of Law, Medicine & Ethics
JF - Journal of Law, Medicine & Ethics
Y1 - 2007/12/03/Dec2007 Supplement 4
VL - 35
M3 - Article
SP - 83
EP - 91
PB - Wiley-Blackwell
SN - 10731105
AB - The article focuses on the military legal authorities, and highlights the responsibilities of civilian, and military sectors on public health as discussed by several speakers including Gerald Sienko, John Casciotti, and Cindy Ryan. Sienko stated his concerns on dealing with a place where there is a federal jurisdictions. Casciotti discusses on the facts of military health systems.
KW - PUBLIC health
KW - CIVIL-military relations
KW - SIENKO, Gerald
KW - CASCIOTTI, John
KW - RYAN, Cindy
N1 - Accession Number: 27974250; Casciotti, John 1 Ryan, Cynthia 2 Sienko, Dean Gerald 3 Williams, Robert C. 4; Affiliation: 1: Associate Deputy General Counsel OGC, Department of Defense Hon. Michael Cardin Connecticut General Assembly 2: National Guard Legal Advisor NORAD USNORTHCOM/JA 3: Medical Director Ingham County Health Department 4: Chief of Staff Office of the Surgeon General U.S. Public Health Service; Source Info: Dec2007 Supplement 4, Vol. 35, p83; Subject Term: PUBLIC health; Subject Term: CIVIL-military relations; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: SIENKO, Gerald; People: CASCIOTTI, John; People: RYAN, Cindy; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1748-720X.2007.00219.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Miller, Therese
T1 - Evidence for the Reaffirmation of the U.S. Preventive Services Task Force Recommendation on Screening for High Blood Pressure.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/12/04/
VL - 147
IS - 11
M3 - Article
SP - 787
EP - W232
SN - 00034819
AB - Background: High blood pressure is common, and screening is a well-established evidence-based standard of current medical practice. Purpose: To perform a literature search for new, substantial evidence on screening for high blood pressure that would inform the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. Data Sources: The PubMed and Cochrane databases were searched. The searches were limited to English-language articles on studies of adult humans (age >18 years) that were published between 1 October 2001 and 31 March 2006 in core clinical journals. Study Selection: For the literature on benefits, meta-analyses; systematic reviews; and randomized, controlled trials were included. For harms, meta-analyses; systematic reviews; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases were included. Two reviewers independently reviewed titles, abstracts, and full articles for inclusion. Data Extraction: No new evidence was found on benefits or harms of screening. Two reviewers extracted data from studies on the harms of early treatment, including adverse effects of drug therapy and adverse quality-of-life outcomes. Data Synthesis: No new evidence was found for the benefits of screening for high blood pressure. New evidence on the harms of treatment of early hypertension shows that pharmacologic therapy is associated with common side effects; serious adverse events are uncommon. Limitations: The nonsystematic search may have missed some smaller studies on the benefits and harms of screening and treatment for high blood pressure. Conclusion: No new evidence was found on the benefits of screening. Pharmacotherapy for early hypertension is associated with common side effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL screening
KW - HYPERTENSION
KW - BLOOD pressure
KW - MEDICAL care
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 27746404; Wolff, Tracy 1 Miller, Therese 1; Affiliation: 1: U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; Source Info: 12/4/2007, Vol. 147 Issue 11, p787; Subject Term: MEDICAL screening; Subject Term: HYPERTENSION; Subject Term: BLOOD pressure; Subject Term: MEDICAL care; Subject Term: MEDICAL policy; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moon, Cheol
AU - Kwon, Young Min
AU - Lee, Won Kyu
AU - Park, Yoon Jeong
AU - Yang, Victor C.
T1 - In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cell-penetrating peptide
JO - Journal of Controlled Release
JF - Journal of Controlled Release
Y1 - 2007/12/04/
VL - 124
IS - 1/2
M3 - Article
SP - 43
EP - 50
SN - 01683659
AB - Abstract: In the development of anti-cancer drugs, it is important to yield selective cytotoxicity primarily against tumor tissues. To achieve this goal, the use of a polymer–drug conjugate appears to be appealing, simply because it can take the advantage of the so-called enhanced permeability and retention (EPR) effect due to vascular leak in tumors. Among various types of polymers, polyrotaxane (PR) is an interesting candidate and warrants further consideration. It is a self-assembled polymer made entirely of biocompatible components, by threading α-cyclodextrin (α-CD) molecules with the poly(ethylene glycol) (PEG) chain. The abundance in functional –OH groups on the CD residues renders PR the capability of carrying a large dose of small anti-tumor agents for delivery. Herein, we presented a novel PR-based delivery system using doxorubicin (DOX) as the model anti-cancer drug. Daunorubicin (DNR) was conjugated to the PR polymer via hydrolysable linkages, and upon hydrolysis, doxorubicin was released as the cytotoxic drug. To facilitate an intracellular uptake by the tumor cells of the PR–DOX conjugates, a cell-penetrating low molecular weight protamine (LMWP) peptide was further attached to the two termini of the PR chain. Using an innovative principle established in our laboratory, such as via the inhibition of the cell-penetrating activity by binding with heparin and reversal of this inhibition by subsequent addition of protamine, cellular uptake of the polymer–drug conjugates could be readily regulated. In this paper, we performed in vitro studies to demonstrate the feasibility of this delivery system. The LMWP–PR–DOX conjugates, which yielded a sustained release of DOX over a period of greater than 4 days, were successfully synthesized. Intracellular uptake of these conjugates by A2780 human ovarian cancer cells and regulation of such uptake by heparin and protamine were confirmed by using the MTT assay and also the confocal microscopy method. [Copyright &y& Elsevier]
AB - Copyright of Journal of Controlled Release is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - POLYMERS
KW - TUMORS
KW - CYCLODEXTRINS
KW - Daunorubicin
KW - Doxorubicin
KW - Heparin inhibition
KW - Low molecular weight protamine
KW - Polyrotaxane
N1 - Accession Number: 27530856; Moon, Cheol 1,2 Kwon, Young Min 2 Lee, Won Kyu 3 Park, Yoon Jeong 4 Yang, Victor C. 1,2; Email Address: vcyang@umich.edu; Affiliation: 1: School of Chemical Engineering, Tianjin University, Tianjin 300072, China 2: College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA 3: Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-Gu, Seoul 122-704, South Korea 4: School of Dentistry and Intellectual Biointerface Engineering Center, Seoul National University, 28-2 Yongon-Dong, Jongno-Gu, Seoul 110-749, South Korea; Source Info: Dec2007, Vol. 124 Issue 1/2, p43; Subject Term: CELL-mediated cytotoxicity; Subject Term: POLYMERS; Subject Term: TUMORS; Subject Term: CYCLODEXTRINS; Author-Supplied Keyword: Daunorubicin; Author-Supplied Keyword: Doxorubicin; Author-Supplied Keyword: Heparin inhibition; Author-Supplied Keyword: Low molecular weight protamine; Author-Supplied Keyword: Polyrotaxane; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jconrel.2007.08.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Jeong-Min
AU - Lee, Soon-Tae
AU - Chu, Kon
AU - Jung, Keun-Hwa
AU - Song, Eun-Cheol
AU - Kim, Se-Jeong
AU - Sinn, Dong-In
AU - Kim, Jin-Hee
AU - Park, Dong-Kyu
AU - Kang, Kyung-Mook
AU - Hyung Hong, Nan
AU - Park, Hee-Kwon
AU - Won, Chong-Hyun
AU - Kim, Kyu-Han
AU - Kim, Manho
AU - Kun Lee, Sang
AU - Roh, Jae-Kyu
T1 - Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model
JO - Brain Research
JF - Brain Research
Y1 - 2007/12/05/
VL - 1183
M3 - Article
SP - 43
EP - 50
SN - 00068993
AB - Abstract: Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorrhage (ICH) model. ICH was induced via the stereotaxic infusion of collagenase, and human ASCs (three million cells per animal) isolated from human fresh fat tissue, were intravenously administered at 24 h post-ICH induction. Acute brain inflammation markers, namely, cell numbers positively stained for terminal transferase dUTP nick end labeling (TUNEL), myeloperoxidase (MPO), or OX-42, and brain water content were checked at 3 days post-ICH. In addition, the authors quantified brain degeneration by measuring hemispheric atrophy and perihematomal glial thickness at 6 weeks post-ICH, and determined modified limb placing behavioral scores weekly over 5 weeks post-ICH. The results showed that brain water content, TUNEL+, and MPO+ cell numbers were significantly reduced in the ASC-transplanted rats. ASC transplantation attenuated neurological deficits from 4 to 5 weeks post-ICH, and reduced both the brain atrophy and the glial proliferation at 6 weeks. Transplanted ASCs were found to densely populate perihematomal areas at 6 weeks, and to express endothelial markers (von Willebrand factor and endothelial barrier antigen), but not neuronal or glial markers. In summary, ASCs transplantation in the ICH model reduced both acute cerebral inflammation and chronic brain degeneration, and promoted long-term functional recovery. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAT cells
KW - GROWTH factors
KW - NEUROGLIA
KW - ANTIGENS
KW - Adipose stem cell
KW - Inflammation
KW - Intracerebral hemorrhage
KW - Neuroprotection
KW - Transplantation
N1 - Accession Number: 27659369; Kim, Jeong-Min 1,2 Lee, Soon-Tae 1,2,3 Chu, Kon 1,2 Jung, Keun-Hwa 1,2,4 Song, Eun-Cheol 1,2,5 Kim, Se-Jeong 1 Sinn, Dong-In 1,2 Kim, Jin-Hee 1 Park, Dong-Kyu 1 Kang, Kyung-Mook 1 Hyung Hong, Nan 1 Park, Hee-Kwon 1 Won, Chong-Hyun 6,7 Kim, Kyu-Han 6 Kim, Manho 1,2 Kun Lee, Sang 1,2 Roh, Jae-Kyu 1,2; Email Address: rohjk@snu.ac.kr; Affiliation: 1: Stroke and Stem Cell Laboratory in the Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea 2: Program in Neuroscience, Neuroscience Research Institute of the SNUMRC, Seoul National University, Seoul, South Korea 3: Program in Public Health Service, Seoul National Hospital, Seoul, South Korea 4: Department of Epidemic Intelligence Service, Korea Center for Disease Control and Prevention, Seoul, South Korea 5: Department of Neurology, Inha University Hospital, Incheon, South Korea 6: Department of Dermatology, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University, Seoul, South Korea 7: Department of Dermatology, Boramae Hospital, Seoul National University, Seoul, South Korea; Source Info: Dec2007, Vol. 1183, p43; Subject Term: FAT cells; Subject Term: GROWTH factors; Subject Term: NEUROGLIA; Subject Term: ANTIGENS; Author-Supplied Keyword: Adipose stem cell; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Intracerebral hemorrhage; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Transplantation; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.brainres.2007.09.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Choi, Mina
AU - Han, Beom Seok
AU - Cho, Minjung
AU - Oh, JaeHo
AU - Park, Kidae
AU - Kim, Sung Jun
AU - Kim, Seung Hee
AU - Jeong, Jayoung
T1 - Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2007/12/10/
VL - 175
IS - 1-3
M3 - Article
SP - 24
EP - 33
SN - 03784274
AB - Abstract: In order to evaluate the pulmonary effects and inflammatory mechanisms of ultrafine amorphous silica particles (UFASs), the UFASs suspension was prepared in PBS and intratracheally administered to A/J mice at doses of 0, 2, 10 and 50mg/kg (n =5 per group). Animals were sacrificed at 24h, and 1, 4 or 14 weeks following exposures. At each time point, a bronchoalveolar lavage fluid analysis, histopathological examination, quantitative real-time PCR and immunohistochemistry of the lung tissues were assessed. The intratracheal instillation of UFASs significantly increased the lung weights and total BAL cells following exposures. The histopathological examination revealed that UFASs-induced severe inflammation, with neutrophils, at an early stage and chronic granulomatous inflammation at the later stage. The mRNA and protein levels of IL-1β, IL-6, IL-8, TNF-α, MCP-1 and MIP-2 in lung tissues were significantly increased during the early stages, but there were no changes after weeks 1 (TNF-α) or 4 (IL-1β, IL-6, IL-8, MCP-1 and MIP-2). Instillation of UFASs-induced transient, but very severe lung inflammation. Therefore, the cytokines (IL-1β, IL-6, IL-8 and TNF-α) and chemokines (MCP-1 and MIP-2) play important roles in the inflammation induced by the intratracheal instillation of UFASs. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryobiology
KW - Inflammation
KW - Cytokines
KW - Lung diseases -- Diagnosis
KW - Chemokines
KW - Lung inflammation
KW - Ultrafine amorphous silica particles
N1 - Accession Number: 27640469; Cho, Wan-Seob 1; Choi, Mina 1; Han, Beom Seok 1; Cho, Minjung 1; Oh, JaeHo 1; Park, Kidae 1; Kim, Sung Jun 1; Kim, Seung Hee 1; Jeong, Jayoung; Email Address: jjy_kfda@kfda.go.kr; Affiliations: 1: Division of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea; Issue Info: Dec2007, Vol. 175 Issue 1-3, p24; Thesaurus Term: Cryobiology; Subject Term: Inflammation; Subject Term: Cytokines; Subject Term: Lung diseases -- Diagnosis; Author-Supplied Keyword: Chemokines; Author-Supplied Keyword: Lung inflammation; Author-Supplied Keyword: Ultrafine amorphous silica particles; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.toxlet.2007.09.008
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Slikker Jr., William
AU - Andrews, Russell J.
AU - Trembly, Bruce
T1 - Preface.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2007/12/11/
VL - 1122
M3 - Other
SP - xi
EP - xiii
SN - 00778923
AB - A preface for the 2007 issue of the "Annals of the New York Academy of Sciences" is presented.
KW - PREFACES & forewords
KW - NEUROPROTECTIVE agents
N1 - Accession Number: 27785548; Slikker Jr., William 1 Andrews, Russell J. 2 Trembly, Bruce 3; Affiliation: 1: FDA, National Center for Toxicological Research 2: NASA Ames Research Center, Moffett Field, California 3: Veterans Affairs Medical Cente,r Togus, Maine; Source Info: Dec2007, Vol. 1122, pxi; Subject Term: PREFACES & forewords; Subject Term: NEUROPROTECTIVE agents; Number of Pages: 4p; Document Type: Other
L3 - 10.1196/annals.1403.000
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Forester, Crystal D.
AU - Ham, Jason E.
AU - Wells, J. Raymond
T1 - β-Ionone reactions with ozone and OH radical: Rate constants and gas-phase products
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2007/12/11/
VL - 41
IS - 38
M3 - Article
SP - 8758
EP - 8771
SN - 13522310
AB - The bimolecular rate constants, k OH> β-ionone (118±30)×10−12 cm3 molecule−1 s−1 and , (0.19±0.05)×10−16 cm3 molecule−1 s−1, were measured using the relative rate technique for the reaction of the hydroxyl radical (OH) and ozone (O3) with 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one (β-ionone) at 297±3K and 1atm total pressure. To more clearly define part of β-ionone''s indoor environment degradation mechanism, the products of the β-ionone+OHitalic>β-ionone+O3 reactions were also investigated. The identified β-ionone+OH products were: glyoxal (ethanedial, HC(=O)C(=O)H), and methylglyoxal (2-oxopropanal, CH3C(=O)C(=O)H) and the identified β-ionone+O3 reaction product was 2-oxopropanal. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) were used to propose 2,6,6-trimethylcyclohex-1-ene-1-carbaldehyde as the other major β-ionone+OHitalic>β-ionone+O3 reaction product. The elucidation of this other reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible β-ionone+OHitalic>β-ionone+O3 reaction mechanisms based on previously published volatile organic compound+OHtile organic compound+O3 gas-phase reaction mechanisms. The additional gas-phase products observed from the β-ionone+OH are proposed to be the result of cyclization through a radical intermediate. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ozone
KW - Volatile organic compounds
KW - Mass spectrometry
KW - Ionones
KW - Chemical kinetics
KW - Hydroxyl group
KW - Reaction mechanisms (Chemistry)
KW - Ring formation (Chemistry)
KW - β-Ionone
KW - β-Irisone
KW - 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one
KW - Annelation
KW - Kinetics
KW - Oxygenated organic compounds
KW - Reaction products
N1 - Accession Number: 27717124; Forester, Crystal D. 1; Ham, Jason E. 1; Wells, J. Raymond; Email Address: ozw0@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Dec2007, Vol. 41 Issue 38, p8758; Thesaurus Term: Ozone; Thesaurus Term: Volatile organic compounds; Thesaurus Term: Mass spectrometry; Subject Term: Ionones; Subject Term: Chemical kinetics; Subject Term: Hydroxyl group; Subject Term: Reaction mechanisms (Chemistry); Subject Term: Ring formation (Chemistry); Author-Supplied Keyword: β-Ionone; Author-Supplied Keyword: β-Irisone; Author-Supplied Keyword: 4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one; Author-Supplied Keyword: Annelation; Author-Supplied Keyword: Kinetics; Author-Supplied Keyword: Oxygenated organic compounds; Author-Supplied Keyword: Reaction products; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.atmosenv.2007.07.047
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hewitt, Joanne
AU - Bell, Derek
AU - Simmons, Greg C.
AU - Rivera-Aban, Malet
AU - Wolf, Sandro
AU - Greening, Gail E.
T1 - Gastroenteritis Outbreak Caused by Waterborne Norovirus at a New Zealand Ski Resort.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2007/12/15/
VL - 73
IS - 24
M3 - Article
SP - 7853
EP - 7857
SN - 00992240
AB - In July 2006, public health services investigated an outbreak of acute gastroenteritis among staff and visitors of a popular ski resort in southern New Zealand. The source of the outbreak was a drinking water supply contaminated by human sewage. The virological component of the investigation played a major role in confirming the source of the outbreak. Drinking water, source stream water, and 31 fecal specimens from gastroenteritis outbreak cases were analyzed for the presence of norovirus (NoV). Water samples were concentrated by ultrafiltration, and real-time reverse transcription-PCR (RT-PCR) was used for rapid detection of NoV from both water and fecal samples. The implicated NoV strain was further characterized by DNA sequencing. NoV genogroup GI/5 was identified in water samples and linked case fecal specimens, providing clear evidence of the predominant pathogen and route of exposure. A retrospective cohort study demonstrated that staff who consumed drinking water from the resort supply were twice as likely to have gastroenteritis than those who did not. This is the first time that an outbreak of gastroenteritis in New Zealand has been conclusively linked to NoV detected in a community water supply. To our knowledge, this is the first report of the use of ultrafiltration combined with quantitative real-time RT-PCR and DNA sequencing for investigation of a waterborne NoV outbreak. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS
KW - ULTRAFILTRATION
KW - NUCLEIC acids
KW - HUMAN services
KW - GENES
KW - WATER supply
KW - DRINKING water
N1 - Accession Number: 29856345; Hewitt, Joanne 1 Bell, Derek 2 Simmons, Greg C. 3 Rivera-Aban, Malet 1 Wolf, Sandro 1 Greening, Gail E. 1; Email Address: gail.greening@esr.cri.nz; Affiliation: 1: Communicable Disease Group, Institute of Environmental Science & Research Ltd., Kenepuru Science Centre, P.O. Box 50-348, Porirua, New Zealand 2: Public Health South, P.O. Box 2180, Queenstown, New Zealand 3: Auckland Regional Public Health Service, Private Bag 92605, Auckland, New Zealand; Source Info: Dec2007, Vol. 73 Issue 24, p7853; Subject Term: GASTROENTERITIS; Subject Term: ULTRAFILTRATION; Subject Term: NUCLEIC acids; Subject Term: HUMAN services; Subject Term: GENES; Subject Term: WATER supply; Subject Term: DRINKING water; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; Number of Pages: 5p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1128/AEM.00718-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=29856345&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kisin, Elena R.
AU - Murray, Ashley R.
AU - Keane, Michael J.
AU - Shi, Xiao-Chun
AU - Schwegler-Berry, Diane
AU - Gorelik, Olga
AU - Arepalli, Sivaram
AU - Castranova, Vincent
AU - Wallace, William E.
AU - Kagan, Valerian E.
AU - Shvedova, Anna A.
T1 - Single-walled Carbon Nanotubes: Geno- and Cytotoxic Effects in Lung Fibroblast V79 Cells.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2007/12/15/
VL - 70
IS - 24
M3 - Article
SP - 2071
EP - 2079
SN - 15287394
AB - With the development of nanotechnology, there is a tremendous growth of the application of nanomaterials, which increases the risk of human exposure to these nanomaterials through inhalation, ingestion, and dermal penetration. Among different types of nanoparticles, single-walled carbon nanotubes (SWCNT) with extremely small size (1 nm in diameter) exhibit extraordinary properties and offer possibilities to create materials with astounding features. Since the release of nanoparticles in an enclosed environment is of great concern, a study of possible genotoxic effects is important. Our previous data showed that pharyngeal aspiration of SWCNT elicited pulmonary effects in C57BL/6 mice that was promoted by a robust, acute inflammatory reaction with early onset resulting in progressive interstitial fibrogenic response and the formation of granulomas. In the present study, the genotoxic potential of SWCNT was evaluated in vitro. The genotoxic effects of nanoparticles were examined using three different test systems: the comet assay and micronucleus (MN) test in a lung fibroblast (V79) cell line, and the Salmonella gene mutation assay in strains YG1024/YG1029. Cytotoxicity tests showed loss of viability in a concentration- and time-dependent manner after exposure of cells to SWCNT. Results from the comet assay demonstrated the induction of DNA damage after only 3 h of incubation with 96 μg/cm2 of SWCNT. The MN test indicated some but not significant micronucleus induction by SWCNT in the V79 cell line at the highest concentrations tested. With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health research
KW - NANOSTRUCTURED materials
KW - DISEASES -- Causes & theories of causation
KW - FIBROBLASTS -- Diseases
KW - LUNG diseases
KW - NANOPARTICLES
KW - CARBON nanotubes
KW - NANOTECHNOLOGY
KW - FOOD poisoning
KW - RISK factors
N1 - Accession Number: 27665509; Kisin, Elena R. 1,2 Murray, Ashley R. 2 Keane, Michael J. 3 Shi, Xiao-Chun 3 Schwegler-Berry, Diane 1 Gorelik, Olga 4 Arepalli, Sivaram 4 Castranova, Vincent 1,2 Wallace, William E. 3 Kagan, Valerian E. 5,6 Shvedova, Anna A. 1,2; Email Address: ats1@cdc.gov; Affiliation: 1: Pathology/Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA 3: Exposure Assesment Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 4: Lockheed Martin Corporation, Engineering Directorate, Materials and Processes Branch, and Nanotube Team, GBTech, Inc., NASA-JSC, Houston, Texas, USA 5: Center for Free Radical and Antioxidant Health, Pittsburgh, Pennsylvania, USA 6: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Source Info: Dec2007, Vol. 70 Issue 24, p2071; Subject Term: PUBLIC health research; Subject Term: NANOSTRUCTURED materials; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: FIBROBLASTS -- Diseases; Subject Term: LUNG diseases; Subject Term: NANOPARTICLES; Subject Term: CARBON nanotubes; Subject Term: NANOTECHNOLOGY; Subject Term: FOOD poisoning; Subject Term: RISK factors; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15287390701601251
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27665509&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kovalenko, V.M.
AU - Bagnyukova, T.V.
AU - Sergienko, O.V.
AU - Bondarenko, L.B.
AU - Shayakhmetova, G.M.
AU - Matvienko, A.V.
AU - Pogribny, I.P.
T1 - Epigenetic changes in the rat livers induced by pyrazinamide treatment
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2007/12/15/
VL - 225
IS - 3
M3 - Article
SP - 293
EP - 299
SN - 0041008X
AB - Abstract: Drug-induced liver injury, including drug-induced hepatotoxicity during the treatment of tuberculosis infection, is a major health problem with increasingly significant challenges to modern hepatology. Therefore, the assessment and monitoring of the hepatotoxicity of antituberculosis drugs for prevention of liver injury are great concerns during disease treatment. The recently emerged data showing the ability of toxicants, including pharmaceutical agents, to alter cellular epigenetic status, open a unique opportunity for early detection of drug hepatotoxicity. Here we report that treatment of male Wistar rats with antituberculosis drug pyrazinamide at doses of 250, 500 or 1000 mg/kg/day body weight for 45 days leads to an early and sustained decrease in cytosine DNA methylation, progressive hypomethylation of long interspersed nucleotide elements (LINE-1), and aberrant promoter hypermethylation of placental form glutathione-S-transferase (GSTP) and p16 INK4A genes in livers of pyrazinamide-treated rats, while serum levels of bilirubin and activity of aminotransferases changed modestly. The early occurrence of these epigenetic alterations and their association with progression of liver injury specific pathological changes indicate that alterations in DNA methylation may be useful predictive markers for the assessment of drug hepatotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Physiology
KW - PYRAZINAMIDE
KW - ANTITUBERCULAR agents
KW - HEPATOTOXICOLOGY
KW - THERAPEUTIC use
KW - DNA methylation
KW - Liver injury
KW - Pyrazinamide
KW - Rat
N1 - Accession Number: 27722242; Kovalenko, V.M. 1 Bagnyukova, T.V. 2 Sergienko, O.V. 1 Bondarenko, L.B. 1 Shayakhmetova, G.M. 1 Matvienko, A.V. 1 Pogribny, I.P. 2; Email Address: igor.pogribny@fda.hhs.gov; Affiliation: 1: Institute of Pharmacology and Toxicology of the Academy of Medical Sciences of Ukraine, Kyiv, Ukraine 2: National Center for Toxicological Research, Jefferson, AR, USA; Source Info: Dec2007, Vol. 225 Issue 3, p293; Subject Term: LIVER -- Physiology; Subject Term: PYRAZINAMIDE; Subject Term: ANTITUBERCULAR agents; Subject Term: HEPATOTOXICOLOGY; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Liver injury; Author-Supplied Keyword: Pyrazinamide; Author-Supplied Keyword: Rat; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.taap.2007.08.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27722242&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thakur, Siddhartha
AU - Tadesse, Daniel A.
AU - Morrow, Morgan
AU - Gebreyes, Wondwossen A.
T1 - Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2007/12/15/
VL - 125
IS - 3/4
M3 - Article
SP - 362
EP - 367
SN - 03781135
AB - Abstract: This cross-sectional study was conducted to determine the prevalence and antimicrobial resistance of Salmonella species in swine reared in the intensive (indoor) and extensive (outdoor) ABF production systems at farm and slaughter in North Carolina, U.S.A. We sampled a total of 279 pigs at farm (extensive 107; intensive 172) and collected 274 carcass swabs (extensive 124; intensive 150) at slaughter. Salmonella species were tested for their susceptibility against 12 antimicrobial agents using the Kirby–Bauer disk diffusion method. Serogrouping was done using polyvalent and group specific antisera. A total of 400 salmonellae were isolated in this study with a significantly higher Salmonella prevalence from the intensive (30%) than the extensive farms (0.9%) (P <0.001). At slaughter, significantly higher Salmonella was isolated at the pre- and post-evisceration stages from extensively (29% pre-evisceration and 33.3% post-evisceration) than the intensively (2% pre-evisceration and 6% post-evisceration) reared swine (P <0.001). The isolates were clustered in six serogroups including B, C, E1, E4, G and R. Highest frequency of antimicrobial resistance was observed against tetracycline (78.5%) and streptomycin (31.5%). A total of 13 antimicrobial resistance patterns were observed including the pentaresistant strains with ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline resistance pattern observed only among isolates from the intensive farms (n =28) and all were serotype Salmonella typhimurium var. Copenhagen. In conclusion, this study shows that multidrug resistant Salmonella are prevalent in ABF production systems despite the absence of antimicrobial selection pressure. In addition, it also highlights the possible role played by slaughterhouse and other environmental factors in the contamination and dissemination of antimicrobial resistant Salmonella in ABF production systems. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA infections in animals
KW - DRUG resistance
KW - ANTI-infective agents
KW - NORTH Carolina
KW - Antimicrobial-free production system
KW - Antimicrobials
KW - Multidrug resistance
KW - Salmonella species
KW - Swine
N1 - Accession Number: 27153711; Thakur, Siddhartha 1 Tadesse, Daniel A. 2 Morrow, Morgan 3 Gebreyes, Wondwossen A. 2; Email Address: gebreyes.1@osu.edu; Affiliation: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, United States 2: Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, 1920 Coffey Road, Columbus, OH 43210, United States 3: College of Agriculture and Life Sciences, Department of Animal Sciences, North Carolina State University, 4700 Hillsborough ST., Raleigh, NC 27606, United States; Source Info: Dec2007, Vol. 125 Issue 3/4, p362; Subject Term: SALMONELLA infections in animals; Subject Term: DRUG resistance; Subject Term: ANTI-infective agents; Subject Term: NORTH Carolina; Author-Supplied Keyword: Antimicrobial-free production system; Author-Supplied Keyword: Antimicrobials; Author-Supplied Keyword: Multidrug resistance; Author-Supplied Keyword: Salmonella species; Author-Supplied Keyword: Swine; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vetmic.2007.05.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27153711&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Guirguis-Blake, Janelle
AU - Miller, Therese
AU - Gillespie, Michael
AU - Harris, Russell
T1 - Screening for Carotid Artery Stenosis: An Update of the Evidence for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2007/12/18/
VL - 147
IS - 12
M3 - Article
SP - 860
EP - W255
SN - 00034819
AB - Background: Cerebrovascular disease is the third leading cause of death in the United States. The proportion of all strokes attributable to previously asymptomatic carotid artery stenosis (CAS) is low. In 1996, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening of asymptomatic persons for CAS by using physical examination or carotid ultrasonography. Purpose: To examine the evidence of benefits and harms of screening asymptomatic patients with duplex ultrasonography and treatment with carotid endarterectomy for CAS. Data Sources: MEDLINE and Cochrane Library (search dates January 1994 to April 2007), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. Study Selection: English-language randomized, controlled trials (RCTs) of screening for CAS; RCTs of carotid endarterectomy versus medical treatment; systematic reviews of screening tests; and observational studies of harms from carotid endarterectomy were selected to answer the following questions: Is there direct evidence that screening with ultrasonography for asymptomatic CAS reduces strokes? What is the accuracy of ultrasonography to detect CAS? Does intervention with carotid endarterectomy reduce morbidity or mortality? Does screening or carotid endarterectomy result in harm? Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined Task Force criteria. Data Synthesis: No RCTs of screening for CAS have been done. According to systematic reviews, the sensitivity of ultrasonography is approximately 94% and the specificity is approximately 92%. Treatment of CAS in selected patients by selected surgeons could lead to an approximately 5—percentage point absolute reduction in strokes over 5 years. Thirty-day stroke and death rates from carotid endarterectomy vary from 2.7% to 4.7% in RCTs; higher rates have been reported in observational studies (up to 6.7%). Limitations: Evidence is inadequate to stratify people into categories of risk for clinically important CAS. The RCTs of carotid endarterectomy versus medical treatment were conducted in selected populations with selected surgeons. Conclusion: The actual stroke reduction from screening asymptomatic patients and treatment with carotid endarterectomy is unknown; the benefit is limited by a low overall prevalence of treatable disease in the general asymptomatic population and harms from treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL screening
KW - CEREBROVASCULAR disease
KW - BRAIN diseases
KW - CAROTID artery
KW - SYSTEMATIC reviews (Medical research)
KW - INTERNET in medicine
KW - CLINICAL trials
N1 - Accession Number: 27961099; Wolff, Tracy 1 Guirguis-Blake, Janelle 2 Miller, Therese 1 Gillespie, Michael 3 Harris, Russell 4; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Tacoma Family Medicine Residency, Department of Family Medicine, University of Washington, 521 Martin Luther King Jr. Way, Tacoma, WA 98405 3: School of Medicine, University of North Carolina, CB #7075, 6th Floor, Burnett-Womack Building, 099 Manning Drive, Chapel Hill, NC 27599 4: School of Medicine, University of North Carolina, CB #7590, Sheps Center, 725 Martin Luther King Jr. Boulevard, Chapel Hill, NC 27599-7590; Source Info: 12/18/2007, Vol. 147 Issue 12, p860; Subject Term: MEDICAL screening; Subject Term: CEREBROVASCULAR disease; Subject Term: BRAIN diseases; Subject Term: CAROTID artery; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: INTERNET in medicine; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 17p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27961099&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105884025
T1 - Screening for Carotid Artery Stenosis: An Update of the Evidence for the U.S. Preventive Services Task Force.
AU - Wolff T
AU - Guirguis-Blake J
AU - Miller T
AU - Gillespie M
AU - Harris R
Y1 - 2007/12/18/
N1 - Accession Number: 105884025. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Carotid Stenosis -- Surgery
KW - Carotid Stenosis -- Ultrasonography
KW - Health Screening
KW - Carotid Stenosis -- Complications
KW - Endarterectomy, Carotid -- Adverse Effects
KW - Medical Practice, Evidence-Based
KW - Reproducibility of Results
KW - Research, Medical
KW - Risk Factors
KW - Stents
KW - Stroke -- Prevention and Control
KW - Ultrasonography, Doppler, Duplex
KW - Human
SP - 860
EP - 870
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 147
IS - 12
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Cerebrovascular disease is the third leading cause of death in the United States. The proportion of all strokes attributable to previously asymptomatic carotid artery stenosis (CAS) is low. In 1996, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening of asymptomatic persons for CAS by using physical examination or carotid ultrasonography. PURPOSE: To examine the evidence of benefits and harms of screening asymptomatic patients with duplex ultrasonography and treatment with carotid endarterectomy for CAS. DATA SOURCES: MEDLINE and Cochrane Library (search dates January 1994 to April 2007), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. STUDY SELECTION: English-language randomized, controlled trials (RCTs) of screening for CAS; RCTs of carotid endarterectomy versus medical treatment; systematic reviews of screening tests; and observational studies of harms from carotid endarterectomy were selected to answer the following questions: Is there direct evidence that screening with ultrasonography for asymptomatic CAS reduces strokes? What is the accuracy of ultrasonography to detect CAS? Does intervention with carotid endarterectomy reduce morbidity or mortality? Does screening or carotid endarterectomy result in harm? DATA EXTRACTION: All studies were reviewed, abstracted, and rated for quality by using predefined Task Force criteria. DATA SYNTHESIS: No RCTs of screening for CAS have been done. According to systematic reviews, the sensitivity of ultrasonography is approximately 94% and the specificity is approximately 92%. Treatment of CAS in selected patients by selected surgeons could lead to an approximately 5-percentage point absolute reduction in strokes over 5 years. Thirty-day stroke and death rates from carotid endarterectomy vary from 2.7% to 4.7% in RCTs; higher rates have been reported in observational studies (up to 6.7%). LIMITATIONS: Evidence is inadequate to stratify people into categories of risk for clinically important CAS. The RCTs of carotid endarterectomy versus medical treatment were conducted in selected populations with selected surgeons. CONCLUSION: The actual stroke reduction from screening asymptomatic patients and treatment with carotid endarterectomy is unknown; the benefit is limited by a low overall prevalence of treatable disease in the general asymptomatic population and harms from treatment.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850
U2 - PMID: 18087057.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105884025&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kobayashi, Norimoto
AU - Karisola, Piia
AU - Peña-Cruz, Victor
AU - Dorfman, David M.
AU - Jinushi, Masahisa
AU - Umetsu, Sarah E.
AU - Butte, Manish J.
AU - Nagumo, Haruo
AU - Chernova, Irene
AU - Zhu, Baogong
AU - Sharpe, Arlene H.
AU - Ito, Susumu
AU - Dranoff, Glenn
AU - Kaplan, Gerardo G.
AU - Casasnovas, Jose M.
AU - Umetsu, Dale T.
AU - DeKruyff, Rosemarie H.
AU - Freeman, Gordon J.
T1 - TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
JO - Immunity
JF - Immunity
Y1 - 2007/12/21/
VL - 27
IS - 6
M3 - Article
SP - 927
EP - 940
SN - 10747613
AB - Summary: The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested. TIM-4+ peritoneal macrophages, TIM-1+ kidney cells, and TIM-4- or TIM-1-transfected cells efficiently phagocytosed apoptotic cells, and phagocytosis could be blocked by TIM-4 or TIM-1 monoclonal antibodies. Mutations in the unique cavity of TIM-4 eliminated PS binding and phagocytosis. TIM-4 mAbs that blocked PS binding and phagocytosis mapped to epitopes in this binding cavity. These results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity. [Copyright &y& Elsevier]
AB - Copyright of Immunity is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGEN-antibody reactions
KW - PHAGOCYTOSIS
KW - KILLER cells
KW - IMMUNOGLOBULINS
KW - CELLIMMUNO
KW - MOLIMMUNO
N1 - Accession Number: 27946853; Kobayashi, Norimoto 1 Karisola, Piia 2 Peña-Cruz, Victor 1 Dorfman, David M. 3 Jinushi, Masahisa 1 Umetsu, Sarah E. 4 Butte, Manish J. 5 Nagumo, Haruo 1 Chernova, Irene 1 Zhu, Baogong 1 Sharpe, Arlene H. 5 Ito, Susumu 6 Dranoff, Glenn 1 Kaplan, Gerardo G. 7 Casasnovas, Jose M. 8 Umetsu, Dale T. 2 DeKruyff, Rosemarie H. 2 Freeman, Gordon J. 1; Email Address: gordon_freeman@dfci.harvard.edu; Affiliation: 1: Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 2: Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA 3: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA 4: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, Harvard Medical School, Boston, MA 02115, USA 5: Department of Pathology, Harvard Medical School, Boston, MA 02115, USA 6: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA 7: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 8: Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain; Source Info: Dec2007, Vol. 27 Issue 6, p927; Subject Term: ANTIGEN-antibody reactions; Subject Term: PHAGOCYTOSIS; Subject Term: KILLER cells; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: CELLIMMUNO; Author-Supplied Keyword: MOLIMMUNO; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.immuni.2007.11.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27946853&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Santiago, César
AU - Ballesteros, Angela
AU - Martínez-Muñoz, Laura
AU - Mellado, Mario
AU - Kaplan, Gerardo G.
AU - Freeman, Gordon J.
AU - Casasnovas, José M.
T1 - Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds
JO - Immunity
JF - Immunity
Y1 - 2007/12/21/
VL - 27
IS - 6
M3 - Article
SP - 941
EP - 951
SN - 10747613
AB - Summary: The T cell immunoglobulin and mucin domain (TIM) proteins are important regulators of T cell responses. Crystal structures of the murine TIM-4 identified a metal-ion-dependent ligand binding site (MILIBS) in the immunoglobulin (Ig) domain of the TIM family. The characteristic CC′ loop of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic compounds penetrate and coordinate to a metal ion bound to conserved residues in the TIM proteins. The structure of phosphatidylserine bound to the Ig domain showed that the hydrophilic head penetrates into the MILIBS and coordinates with the metal ion, whereas the aromatic residues on the tip of the FG loop interacted with the fatty acid chains and could insert into the lipid bilayer. Our results also revealed an important role of the MILIBS in the trafficking of TIM-1 to the cell surface. [Copyright &y& Elsevier]
AB - Copyright of Immunity is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - BIOCHEMISTRY
KW - LYMPHOCYTES
KW - CELL membranes
KW - MOLIMMUNO
N1 - Accession Number: 27946854; Santiago, César 1 Ballesteros, Angela 1 Martínez-Muñoz, Laura 1 Mellado, Mario 1 Kaplan, Gerardo G. 2 Freeman, Gordon J. 3 Casasnovas, José M. 1; Email Address: jcasasnovas@cnb.uam.es; Affiliation: 1: Centro Nacional de Biotecnología, CSIC, Campus Universidad Autónoma, 28049 Madrid, Spain 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Source Info: Dec2007, Vol. 27 Issue 6, p941; Subject Term: T cells; Subject Term: BIOCHEMISTRY; Subject Term: LYMPHOCYTES; Subject Term: CELL membranes; Author-Supplied Keyword: MOLIMMUNO; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.immuni.2007.11.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27946854&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rath, Barbara
AU - Linder, Thomas
AU - Cornblath, David
AU - Hudson, Michael
AU - Fernandopulle, Rohini
AU - Hartmann, Katharina
AU - Heininger, Ulrich
AU - Izurieta, Hector
AU - Killion, Leslie
AU - Kokotis, Pangiotis
AU - Oleske, James
AU - Vajdy, Michael
AU - Wong, Virginia
T1 - “All that palsies is not Bell's ”—The need to define Bell's palsy as an adverse event following immunization
JO - Vaccine
JF - Vaccine
Y1 - 2007/12/21/
VL - 26
IS - 1
M3 - Article
SP - 1
EP - 14
SN - 0264410X
AB - Summary: Bell''s palsy has been reported as an adverse event following immunization (AEFI). Review of the published literature reveals that several characteristics have been used to describe Bell''s palsy, which differ significantly from author to author. Evidently, the definition of “Bell''s palsy” remains controversial, and consensus between different medical subspecialties is urgently needed. The Brighton Collaboration has formed an international working group with representatives of neurology, otorhinolaryngology, pediatrics, electrophysiology, pharmacology, pharmaceutical and biotech industry as well as regulatory agencies to create a case definition of Bell''s palsy as an AEFI. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemicals -- Physiological effect
KW - Facial paralysis
KW - Immunization -- Complications
KW - Immunotherapy
KW - AEFI
KW - Bell's palsy
KW - Clinical definition
N1 - Accession Number: 27831940; Rath, Barbara 1; Email Address: Barbara.Rath@gmail.com; Linder, Thomas 2; Cornblath, David 3; Hudson, Michael 4; Fernandopulle, Rohini 5; Hartmann, Katharina 6; Heininger, Ulrich 1; Izurieta, Hector 7; Killion, Leslie 8; Kokotis, Pangiotis 9; Oleske, James 10; Vajdy, Michael 11; Wong, Virginia 12; Affiliations: 1: University Children's Hospital Basel, Basel, Switzerland; 2: Department of Otorhinolaryngology, Kantonsspital Luzern, Lucerne, Switzerland; 3: Department of Neurology, Johns Hopkins University Hospital, Baltimore, MD, USA; 4: Health Protection Agency, Salisbury, United Kingdom; 5: Department of Pharmacology, International Medical University, Kuala Lumpur, Malaysia; 6: Berna Biotech Ltd., Bern, Switzerland; 7: Food and Drug Administration, Rockville, MD, USA; 8: Wyeth Pharmaceuticals, Collegeville, PA, USA; 9: Electomyography Laboratory, University of Athens, Aeginitio Hospital, Athens, Greece; 10: Department of Pediatrics, University Hospital, New Jersey Medical School, Newark, NJ, USA; 11: Novartis Vaccines and Diagnostics, Inc., Emeryville, CA, USA; 12: Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong; Issue Info: Dec2007, Vol. 26 Issue 1, p1; Thesaurus Term: Chemicals -- Physiological effect; Subject Term: Facial paralysis; Subject Term: Immunization -- Complications; Subject Term: Immunotherapy; Author-Supplied Keyword: AEFI; Author-Supplied Keyword: Bell's palsy; Author-Supplied Keyword: Clinical definition; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.10.043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27831940&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cohen, Bernard J.
AU - Audet, Susette
AU - Andrews, Nick
AU - Beeler, Judy
T1 - Plaque reduction neutralization test for measles antibodies: Description of a standardised laboratory method for use in immunogenicity studies of aerosol vaccination
JO - Vaccine
JF - Vaccine
Y1 - 2007/12/21/
VL - 26
IS - 1
M3 - Article
SP - 59
EP - 66
SN - 0264410X
AB - Abstract: Background: Clinical trials of measles vaccination administered as aerosol are planned with the aim of obtaining licensure. Measles antibody levels will be measured using the plaque reduction neutralization test (PRNT) to assess antibody responses as a surrogate marker of efficacy. Methods: A working group examined laboratory protocols for measles PRNT in use at three reference centres and agreed to a standardised procedure, which was subsequently validated. Results: Assay validation showed quantitative results varied approximately threefold both within and between assays. The lower limit of detection was approximately 20milliInternational Units/mL. Conclusions: A standardised laboratory protocol for measles PRNT was established and validated for use in clinical trials of aerosolized measles vaccines. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Viral antibodies
KW - Measles
KW - Immunogenetics
KW - Measles
KW - Plaque reduction neutralization test
N1 - Accession Number: 27831946; Cohen, Bernard J. 1; Email Address: Bernard.cohen@hpa.org.uk; Audet, Susette 2; Andrews, Nick 1; Beeler, Judy 2; Affiliations: 1: Centre for Infections, Health Protection Agency, London NW9 5EQ, UK; 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Dec2007, Vol. 26 Issue 1, p59; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Subject Term: Viral antibodies; Subject Term: Measles; Subject Term: Immunogenetics; Author-Supplied Keyword: Measles; Author-Supplied Keyword: Plaque reduction neutralization test; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.10.046
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=27831946&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - Gen
ID - 9999-24460-000
AN - 9999-24460-000
AU - Mitchell, Monica J.
AU - Witman, Marjorie
AU - Taffaro, Craig
T1 - Pre- and Post-Katrina Mental Health Symptoms Survey
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2008///
AD - Mitchell, Monica J., Cincinnati Children’s Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, 3333 Burnet Avenue, MLC #3015, Cincinnati, Ohio, United States, 45229-3039
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-24460-000. Partial author list: First Author & Affiliation: Mitchell, Monica J.; Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States. Release Date: 20131111. Correction Date: 20151109. Instrument Type: Survey. Test Location: Table 2, Page 71; Table 3, Page 72. Test Format: This measure utilizes a multiple-choice response format.. Language: English. Constructs: Hurricane Katrina Disaster Experiences; Mental Disorders; Classification: Trauma, Stress, and Coping (7800); Mental Health/Illness Related Assessment (6700). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380).
N2 - Administration Method: Interview
AB - Purpose: The purpose of the Pre- and Post-Katrina Mental Health Symptoms Survey is to assess patients’ mental health before and after Hurricane Katrina.
AB - Description: The Pre- and Post-Katrina Mental Health Symptoms Survey (Mitchell, Witman, & Taffaro, 2008) was developed to assess patients’ mental health before and after Hurricane Katrina. This survey interview tool measure mental health retrospectively at four distinct time points: (a) 4 months pre- Katrina (May–August 2005), (b) 4 months following Katrina (September–December 2005), (c) the past 4 months (March–July 2006), and (d) the past 2 weeks (July 27–August 11, 2006). Written dates serve as secondary prompts for each time point, and verbal prompts are used to help clarify survey participants’ memories. Participants have the option of saying that they had not had the symptom in the past 18 months from early 2005 (pre-Katrina) until the date of the survey. The symptoms assessed were derived from the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) and include criteria for clinical depression, anxiety, panic disorder, and posttraumatic stress disorder. Participants are also asked whether their alcohol intake had increased and whether they are taking medication for mental health disorders. Finally, participants are asked whether their mental health and physical health (two separate questions) are the same, better, or worse than 1 year ago. Participants are asked other relevant questions that could affect mental health status. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Pre- and Post-Katrina Mental Health Symptoms Survey
KW - Test Development
U5 - Pre- and Post-Katrina Mental Health Symptoms Survey [Test Development]Reestablishing mental health services in St. Bernard Parish, Louisiana, following Hurricane Katrina. (AN: 2008-01847-011 from PsycINFO) Mitchell, Monica J.; Witman, Marjorie; Taffaro, Craig; Feb, 2008. Source: Professional Psychology: Research and Practice. 39(1), American Psychological Association, US; Feb, 2008; Administration: Interview Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Sample: Health Center Clients (Ages 18-80); Location: United States Keywords: Pre- and Post-Katrina Mental Health Symptoms Survey; Test Development; Subjects: Mental Disorders; Mental Health; Natural Disasters; Surveys; Symptoms; Test Construction;
DO - 10.1037/t24460-000
L3 - Full; Full text; 999924460_full_001.pdf
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UR - monica.mitchell@cchmc.org
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - Mazurek, Jacek M.
AU - Filios, Margaret
AU - Willis, Ruth
AU - Rosenman, Kenneth D.
AU - Reilly, Mary Jo
AU - McGreevy, Katharine
AU - Schill, Donald P.
AU - Valiante, David
AU - Pechter, Elise
AU - Davis, Letitia
AU - Flattery, Jennifer
AU - Harrison, Robert
T1 - Work-Related Asthma in the Educational Services Industry: California, Massachusetts, Michigan, and New Jersey, 1993-2000.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/01//
VL - 51
IS - 1
M3 - Article
SP - 47
EP - 59
SN - 02713586
AB - The article presents a study that investigates on the prevalence of work-related asthma (WRA) in educational services industry in the U.S. The study was carried out 2,995 WRA cases based on state occupational disease surveillance systems from 1993 to 2000 in four American states, including California, Massachusetts, New Jersey and Michigan. It reveals that 265 participants are working in educational institutions wherein 61% are identified as occupational asthma with higher prevalence in teachers and teacher's aides and 8% as reactive airways dysfunction syndrome which is caused by air pollution, mold, dust and cleaning products. In addition, the author stressed that asthma cases in educational services industry needs immediate initiative to suppress the occupational health related problem.
KW - Asthma
KW - HEALTH
KW - Occupational diseases
KW - Health risk assessment
KW - Disease prevalence
KW - Industrial hygiene
KW - Teachers
KW - Diseases -- Risk factors
KW - Education & training services industry
KW - asthma
KW - occupational health
KW - school
KW - surveillance
KW - teachers
N1 - Accession Number: 30004588; Mazurek, Jacek M. 1; Email Address: acq8@cdc.gov; Filios, Margaret 1; Willis, Ruth 1; Rosenman, Kenneth D. 2; Reilly, Mary Jo 2; McGreevy, Katharine 3; Schill, Donald P. 3; Valiante, David 3; Pechter, Elise 4; Davis, Letitia 4; Flattery, Jennifer 5; Harrison, Robert 5; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Michigan State University, East Lansing, Michigan; 3: New Jersey Department of Health and Senior Services,Trenton, New Jersey; 4: Massachusetts Department of Public Health, Boston, Massachusetts; 5: California Department of Health Services, Oakland, California; Issue Info: Jan2008, Vol. 51 Issue 1, p47; Thesaurus Term: Asthma; Thesaurus Term: HEALTH; Thesaurus Term: Occupational diseases; Thesaurus Term: Health risk assessment; Thesaurus Term: Disease prevalence; Thesaurus Term: Industrial hygiene; Subject Term: Teachers; Subject Term: Diseases -- Risk factors; Subject Term: Education & training services industry; Author-Supplied Keyword: asthma; Author-Supplied Keyword: occupational health; Author-Supplied Keyword: school; Author-Supplied Keyword: surveillance; Author-Supplied Keyword: teachers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 13p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1002/ajim.20539
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105870074
T1 - Designing for safety: evidence-based design and hospitals.
AU - Clancy CM
Y1 - 2008/01//Jan/Feb2008
N1 - Accession Number: 105870074. Language: English. Entry Date: 20080328. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Quality Assurance. NLM UID: 9300756.
KW - Hospital Design and Construction
KW - Medical Practice, Evidence-Based
KW - Safety
KW - United States
SP - 66
EP - 69
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 23
IS - 1
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 18187593.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105870074&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Alexander, Greg R.
AU - Wingate, Martha S.
AU - Bader, Deren
AU - Kogan, Michael D.
T1 - The increasing racial disparity in infant mortality rates: Composition and contributors to recent US trends
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2008/01//
VL - 198
IS - 1
M3 - Article
SP - 51
EP - 51
SN - 00029378
AB - Objectives: We examined trends in birthweight-gestational age distributions and related infant mortality for African American and white women and calculated the estimated excess annual number of African American infant deaths. Study Design: Live births to US-resident mothers with a maternal race of white or African American were selected from the National Center for Health Statistics’ linked live birth-infant death cohort files (1985-1988 and 1995-2000). Results: The racial disparity in infant mortality widened despite an increasing rate of white low-birthweight infants. White preterm infants had relatively greater gains in survival and the white advantage in survival at term increased. Annually, African American women experience approximately 3300 more infant deaths than would be expected. Conclusion: The increasing US racial disparity in infant mortality is largely influenced by changes in birthweight-gestational age–specific mortality, rather than the birthweight-gestational age distribution. Improvement in the survival of white preterm and low-birthweight infants, probably reflecting advances in and changing access to medical technology, contributed appreciably to this trend. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEWBORN infants -- Death
KW - BIRTH weight
KW - MORTALITY
KW - GESTATIONAL age
KW - PREMATURE infants
KW - PREMATURE labor
KW - AFRICAN American women
KW - birthweight
KW - gestational age
KW - infant mortality
KW - race
N1 - Accession Number: 28116384; Alexander, Greg R. 1; Wingate, Martha S. 2; Email Address: mslay@uab.edu; Bader, Deren 3; Kogan, Michael D. 4; Source Information: Jan2008, Vol. 198 Issue 1, p51; Subject: NEWBORN infants -- Death; Subject: BIRTH weight; Subject: MORTALITY; Subject: GESTATIONAL age; Subject: PREMATURE infants; Subject: PREMATURE labor; Subject: AFRICAN American women; Author-Supplied Keyword: birthweight; Author-Supplied Keyword: gestational age; Author-Supplied Keyword: infant mortality; Author-Supplied Keyword: race; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2007.06.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=28116384&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Mercer, R. R.
AU - Scabilloni, J.
AU - Wang, L.
AU - Kisin, E.
AU - Murray, A. R.
AU - Schwegler-Berry, D.
AU - Shvedova, A. A.
AU - Castranova, V.
T1 - Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2008/01//
VL - 38
IS - 1
M3 - Article
SP - L87
EP - L97
SN - 10400605
AB - Nanoparticles have a fundamental dimension of <100 nm. However, on suspension in media, agglomerates of nanoparticles are the more common structure. This is particularly evident in prior intratracheal instillation or aspiration studies of single-walled carbon nanotubes (SWCNT), in which granulomatous lesions encased by epithelioid macrophages were produced by large agglomerates. In this study, we tested the hypothesis of whether exposure to more dispersed SWCNT structures would alter pulmonary distribution and response. A dispersed preparation of single-walled carbon nanotubes (DSWCNT) with a mean diameter of 0.69 p.m was given by pharyngeal aspiration to C57BL/6 mice. Electron microscopy demonstrated a highly dispersed, interstitial distribution of DSWCNT deposits by 1 day postexposure. Deposits were generally <1 μm. Macrophage phagocytosis of DSWCNT was rarely observed at any time point. Lung responses were studied by lavage and morphometry at 1 h,1 day, 7 day, and 1 mo after a single DSWCNT exposure of 10 μg/mouse. Lung sections and lavage cells demonstrated an early, transient neutrophilic and inflammatory phase that rapidly resolved and was similar to that observed with large agglomerates. No granulomatous lesions or epithelioid macrophages were detected. Morphometric measurement of Sirius red staining was used to assess the connective tissue response. The average thickness of connective tissue in alveolar regions was 0.10 ± 0.02, 0.09 ± 0.02, 0.10 ± 0.01, 0.48 ± 0.04, and 0.88 ± 0.19 μm for PBS and 1-h, 1-day, 7-day, and 1-mo postexposure groups, respectively. The results demonstrate that dispersed SWCNT are rapidly incorporated into the alveolar interstitium and that they produce an increase in collagen deposition. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - VIRUS diseases
KW - EXTRACELLULAR matrix proteins
KW - GREEN fluorescent protein
KW - OBSTRUCTIVE lung diseases
KW - MICROBIAL genetics
KW - emerging technologies
KW - lung injury
KW - nanoparticles
KW - particulates
KW - toxicology
N1 - Accession Number: 28615193; Mercer, R. R. 1,2; Email Address: rmercer@cdc.gov Scabilloni, J. 1 Wang, L. 1 Kisin, E. 1 Murray, A. R. 1 Schwegler-Berry, D. 1 Shvedova, A. A. 2 Castranova, V. 1,2; Affiliation: 1: Pathology and Physiology Research Branch, Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 2: Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia; Source Info: Jan2008, Vol. 38 Issue 1, pL87; Subject Term: NANOPARTICLES; Subject Term: VIRUS diseases; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: GREEN fluorescent protein; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: MICROBIAL genetics; Author-Supplied Keyword: emerging technologies; Author-Supplied Keyword: lung injury; Author-Supplied Keyword: nanoparticles; Author-Supplied Keyword: particulates; Author-Supplied Keyword: toxicology; Number of Pages: 11p; Illustrations: 7 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1152/ajplung.00186.2007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28615193&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105870488
T1 - Racial/ethnic minority children's use of psychiatric emergency care in California's Public Mental Health System.
AU - Snowden LR
AU - Masland MC
AU - Libby AM
AU - Wallace N
AU - Fawley K
Y1 - 2008/01//
N1 - Accession Number: 105870488. Language: English. Entry Date: 20080328. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: Supported by National Institute of Mental Health (award R01 MH067871). NLM UID: 1254074.
KW - Child Welfare
KW - Community Mental Health Services -- Utilization
KW - Emergency Medical Services -- Utilization
KW - Medicaid -- Statistics and Numerical Data
KW - Minority Groups -- Statistics and Numerical Data
KW - Adolescence
KW - California
KW - Child
KW - Crisis Intervention -- Statistics and Numerical Data
KW - Female
KW - Funding Source
KW - Logistic Regression
KW - Male
KW - Poverty Areas
KW - Human
SP - 118
EP - 124
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 98
IS - 1
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We examined rates and intensity of crisis services use by race/ethnicity for 351,174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. METHODS: We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). RESULTS: African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. CONCLUSIONS: African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits.
SN - 0090-0036
AD - Center for Mental Health Services Research, School of Social Welfare, 120 Haviland Hall, University of California, Berkeley, CA 94720-7400, USA. snowden@berkeley.edu
U2 - PMID: 18048783.
DO - 10.2105/AJPH.2006.105361
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105870488&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105761207
T1 - Ultrafine and respirable particles in an automotive grey iron foundry.
AU - Evans DE
AU - Heitbrink WA
AU - Slavin TJ
AU - Peters TM
Y1 - 2008/01//
N1 - Accession Number: 105761207. Language: English. Entry Date: 20080711. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Pollutants, Occupational -- Analysis
KW - Iron
KW - Metallurgy
KW - Environmental Exposure -- Analysis
KW - Environmental Monitoring -- Methods
KW - Occupational Exposure -- Analysis
KW - Particle Size
KW - Seasons
SP - 9
EP - 21
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 1
PB - Oxford University Press / USA
SN - 0003-4878
AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA.
U2 - PMID: 18056626.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105761207&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105761203
T1 - A comparison of the CATHIA-T sampler, the GK2.69 cyclone and the standard cowled sampler for thoracic fiber concentrations at a Taconite (iron ore)-processing mill.
AU - Lee EG
AU - Harper M
AU - Nelson J
AU - Hintz PJ
AU - Andrew ME
Y1 - 2008/01//
N1 - Accession Number: 105761203. Language: English. Entry Date: 20080711. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Pollutants, Occupational -- Analysis
KW - Environmental Monitoring -- Equipment and Supplies
KW - Metallurgy
KW - Minerals -- Analysis
KW - Environmental Exposure -- Analysis
KW - Environmental Monitoring -- Methods
KW - Iron
KW - Particle Size
KW - Reproducibility of Results
KW - Human
SP - 55
EP - 62
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 1
PB - Oxford University Press / USA
SN - 0003-4878
AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505, USA. elee2@cdc.gov
U2 - PMID: 18195326.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105761203&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105978576
T1 - Research linking nurses' work hours to errors prompts more state restrictions.
AU - Hughes RG
AU - Clancy CM
Y1 - 2008/01//
N1 - Accession Number: 105978576. Language: English. Entry Date: 20080215. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 0372403.
KW - Health Care Errors
KW - Nursing Staff, Hospital
KW - Personnel Staffing and Scheduling -- Legislation and Jurisprudence -- United States
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 209
EP - 211
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 87
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality, Rockville, MD.
U2 - PMID: 18184600.
DO - 10.1016/j.aorn.2007.12.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105978576&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Zuvekas, Samuel H.
AD - Agency of Healthcare Research and Quality
AD - Agency of Healthcare Research and Quality
T1 - The Shape of Demand: What Does It Tell Us about Direct-to-Consumer Marketing of Antidepressants?
JO - B.E. Journal of Economic Analysis and Policy: Advances in Economic Analysis and Policy
JF - B.E. Journal of Economic Analysis and Policy: Advances in Economic Analysis and Policy
Y1 - 2008///
VL - 8
IS - 2
SN - 19351682
N1 - Accession Number: 0966726; Keywords: Advertising; Marketing; Pharmaceutical; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200805
N2 - Much of the debate surrounding Direct-to-Consumer Advertising (DTCA) of pharmaceuticals centers on whether DTCA conveys useful information to consumers or indiscriminately increases requests for the advertised medication. By identifying how DTCA changes the shape of the demand curve for antidepressants, we seek to infer the promotional objectives of manufacturers. Using data from the 1996-2003 Medical Expenditure Panel Survey (MEPS), we find that advertising shifts the demand curve for antidepressants outward and rotates it counter-clockwise. DTCA increases the probability that an individual will initiate use of antidepressants, particularly when out-of-pocket medication costs are low, but does not necessarily increase utilization levels among those already taking antidepressants. This is consistent with a promotional campaign that seeks to alert consumers to the product's existence, but conveys no real information that would allow them to learn their true match with the product.
KW - Analysis of Health Care Markets I11
KW - Advertising M37
L3 - http://www.bepress.com/bejeap/advances/
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0966726&site=ehost-live&scope=site
UR - http://www.bepress.com/bejeap/advances/
DP - EBSCOhost
DB - ecn
ER -
TY - CHAP
AU - Williams, Richard A.
AU - Thompson, Kimberly M.
AD - Center for Food Safety and Applied Nutrition, US FDA, College Park, MD
AD - Harvard U
A2 - Zerbe, Richard O., Jr.
T1 - Integrated Analysis: Combining Risk and Economic Assessments While Preserving the Separation of Powers
T2 - Benefit-Cost Anaysis. Volume 2.
PB - Elgar Reference Collection. International Library of Critical Writings in Economics, vol. 229. Cheltenham, U.K. and Northampton, Mass.: Elgar
Y1 - 2008///
SP - 435
EP - 445
RP - [2004]
N1 - Accession Number: 1104451; Reviewed Book ISBN: 978-1-84720-964-1; ; Publication Type: Collective Volume Article; Update Code: 201006
KW - Allocative Efficiency; Cost-Benefit Analysis D61
KW - Information, Knowledge, and Uncertainty: General D80
KW - Health: Government Policy; Regulation; Public Health I18
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Manohar, Manu
AU - Orrison, Brian
AU - Peden, Keith
AU - Lewis, Andrew M.
T1 - Assessing the tumorigenic phenotype of VERO cells in adult and newborn nude mice
JO - Biologicals
JF - Biologicals
Y1 - 2008/01//
VL - 36
IS - 1
M3 - Article
SP - 65
EP - 72
SN - 10451056
AB - Abstract: VERO cell lines are important substrates for viral vaccine manufacture. The mechanism by which these cells became neoplastically transformed is unknown. During tissue-culture passage, VERO cells can develop the capacity to form tumors. Although at the passage levels (around p140) currently used for vaccine manufacture, VERO cells are non-tumorigenic, questions have been raised about safety issues that might be associated with this capacity to acquire a tumorigenic phenotype. To begin to address these issues, the tumorigenicity of VERO cell lines, derived at different passage levels under different growth conditions, were evaluated in 365-day assays in adult and newborn nude mice. High passage (p>200) VERO cell lines established by random passaging in tissue culture produced tumors in adult (10 out of 27) mice and newborn (21 out of 30) mice, respectively. In contrast, a high passage (p>250) cell line established by passage at sub-confluence produced tumors only in newborn mice (16 out of 30). Progressively growing tumors began forming at 36 days in newborns and at 69 days in adults. Higher tumor incidences and shorter tumor latencies suggest that newborn nude mice may be more sensitive than adults in detecting the expression of a tumorigenic phenotype by some VERO cell lines. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMORS
KW - CELL culture
KW - GENOTYPE-environment interaction
KW - VIRUS diseases
KW - Nude mice
KW - Tumorigenicity
KW - VERO cells
N1 - Accession Number: 28651018; Manohar, Manu Orrison, Brian 1 Peden, Keith 1 Lewis, Andrew M.; Email Address: andrew.lewis@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Room 1B10, Building 29A, 29 Lincoln Drive, Bethesda, MD 20892, USA; Source Info: Jan2008, Vol. 36 Issue 1, p65; Subject Term: TUMORS; Subject Term: CELL culture; Subject Term: GENOTYPE-environment interaction; Subject Term: VIRUS diseases; Author-Supplied Keyword: Nude mice; Author-Supplied Keyword: Tumorigenicity; Author-Supplied Keyword: VERO cells; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.biologicals.2007.06.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hendriksen, Coenraad
AU - Arciniega, Juan L.
AU - Bruckner, Lukas
AU - Chevalier, Michel
AU - Coppens, Emmanuelle
AU - Descamps, Johan
AU - Duchêne, Michel
AU - Dusek, David Michael
AU - Halder, Marlies
AU - Kreeftenberg, Hans
AU - Maes, Alexandrine
AU - Redhead, Keith
AU - Ravetkar, Satish D.
AU - Spieser, Jean-Marc
AU - Swam, Hanny
T1 - The consistency approach for the quality control of vaccines
JO - Biologicals
JF - Biologicals
Y1 - 2008/01//
VL - 36
IS - 1
M3 - Article
SP - 73
EP - 77
SN - 10451056
AB - Abstract: Current lot release testing of conventional vaccines emphasizes quality control of the final product and is characterized by its extensive use of laboratory animals. This report, which is based on the outcome of an ECVAM (European Centre for Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy) workshop, discusses the concept of consistency testing as an alternative approach for lot release testing. The consistency approach for the routine release of vaccines is based upon the principle that the quality of vaccines is a consequence of a quality system and of consistent production of lots with similar characteristics to those lots that have been shown to be safe and effective in humans or the target species. The report indicates why and under which circumstances this approach can be applied, the role of the different stakeholders, and the need for international harmonization. It also gives recommendations for its implementation. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - VACCINATION
KW - PREVENTIVE medicine
KW - RESEARCH institutes
KW - Consistency
KW - In vitro
KW - Quality control
KW - Release testing
KW - Vaccines
N1 - Accession Number: 28651019; Hendriksen, Coenraad 1,2 Arciniega, Juan L. 3 Bruckner, Lukas 4 Chevalier, Michel 5 Coppens, Emmanuelle 5 Descamps, Johan 6 Duchêne, Michel 6 Dusek, David Michael 7 Halder, Marlies 8; Email Address: marlies.halder@jrc.it Kreeftenberg, Hans 1 Maes, Alexandrine 9 Redhead, Keith 10 Ravetkar, Satish D. 11 Spieser, Jean-Marc 12 Swam, Hanny 13; Affiliation: 1: Netherlands Vaccine Institute, A. van Leeuwenhoeklaan 11, 3720 AL Bilthoven, The Netherlands 2: Netherlands Centre Alternatives to Animal Use, Utrecht University, 3508 TB Utrecht, The Netherlands 3: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA 4: Institute of Virology and Immunoprophylaxis, CH-3147 Mittelhaeusern, Switzerland 5: Sanofi Pasteur, 1541 avenue M. Mérieux, 69280 Marcy l'Etoile, France 6: GlaxoSmithKline Biologicals, Rue de l' Institut 89, B-1330 Rixensart, Belgium 7: U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Center for Veterinary Biologics, Policy, Evaluation and Licensing, 510 South 17th Street, Ames, IA 50010, USA 8: European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, TP 580, Via Fermi 1, 21020 Ispra, Varese, Italy 9: Scientific Institute of Public Health, Juliette Wytsmanstreet 14, 1050 Brussels, Belgium 10: Intervet UK Ltd, Milton Keynes MK7 7AJ, United Kingdom 11: Serum Institute of India Ltd, 212/2 Hadapsar, Pune 411028, India 12: European Department for the Quality of Medicines, Council of Europe, 7 allée Kastner, CS 30026, 67081 Strasbourg, France 13: Intervet International BV, PO Box 31, 5830 AA Boxmeer, The Netherlands; Source Info: Jan2008, Vol. 36 Issue 1, p73; Subject Term: VACCINES; Subject Term: VACCINATION; Subject Term: PREVENTIVE medicine; Subject Term: RESEARCH institutes; Author-Supplied Keyword: Consistency; Author-Supplied Keyword: In vitro; Author-Supplied Keyword: Quality control; Author-Supplied Keyword: Release testing; Author-Supplied Keyword: Vaccines; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541720 Research and Development in the Social Sciences and Humanities; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.biologicals.2007.05.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105905701
T1 - Extraction and stability of ethylene oxide residue in medical devices.
AU - Lucas AD
AU - Stratmeyer ME
AU - Lucas, Anne D
AU - Stratmeyer, Melvin E
Y1 - 2008/01//Jan/Feb2008
N1 - Accession Number: 105905701. Language: English. Entry Date: 20080502. Revision Date: 20161117. Publication Type: journal article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. NLM UID: 8905560.
KW - Equipment and Supplies
KW - Ethylene Oxide
KW - Sterilization and Disinfection
KW - United States
SP - 76
EP - 79
JO - Biomedical Instrumentation & Technology
JF - Biomedical Instrumentation & Technology
JA - BIOMED INSTRUM TECHNOL
VL - 42
IS - 1
CY - Lawrence, Kansas
PB - Allen Press Publishing Services Inc.
AB - Ethylene oxide (EO) gas is commonly used to sterilize medical devices. A major concern is the amount of residue that may remain on or in the device and be available in the body. Some standards (ASTMF619 and ISO 10993-12) recommend using two different extraction solutions (one polar, one nonpolar), for sample preparation prior to testing medical devices. However, ISO 10993-7 recommends water to process medical devices to determine EO residual levels. To address this, EO residual levels were examined in different extraction solutions. EO residual levels from devices and materials extracted with different solutions were evaluated. Results from this study indicate little difference between extraction solutions of water, cell culture media, and serum (less than 30% difference). Given the increased cost and increased background noise of media or serum over water, using only water to process medical devices and materials for EO residues appears adequate.
SN - 0899-8205
AD - Center for Device and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20903, USA
U2 - PMID: 18257644.
DO - 10.2345/0899-8205(2008)42[76:EASOEO]2.0.CO;2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105905701&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hubbard, Kyle
AU - Catalano, Jennifer
AU - Puri, Raj K.
AU - Gnatt, Averell
T1 - Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
JO - BMC Cancer
JF - BMC Cancer
Y1 - 2008/01//
VL - 8
M3 - Article
SP - 1
EP - 16
PB - BioMed Central
SN - 14712407
AB - Background: A common element among cancer cells is the presence of improperly controlled transcription. In these cells, the degree of specific activation of some genes is abnormal, and altering the aberrant transcription may therefore directly target cancer. TFIIS is a transcription elongation factor, which directly binds the transcription motor, RNA Polymerase II and allows it to read through various transcription arrest sites. We report on RNA interference of TFIIS, a transcription elongation factor, and its affect on proliferation of cancer cells in culture. Methods: RNA interference was performed by transfecting siRNA to specifically knock down TFIIS expression in MCF7, MCF10A, PL45 and A549 cells. Levels of TFIIS expression were determined by the Quantigene method, and relative protein levels of TFIIS, c-myc and p53 were determined by C-ELISA. Induction of apoptosis was determined by an enzymatic Caspase 3/7 assay, as well as a non-enzymatic assay detecting cytoplasmic mono- and oligonucleosomes. A gene array analysis was conducted for effects of TFIIS siRNA on MCF7 and MCF10A cell lines. Results: Knockdown of TFIIS reduced cancer cell proliferation in breast, lung and pancreatic cancer cell lines. More specifically, TFIIS knockdown in the MCF7 breast cancer cell line induced cancer cell death and increased c-myc and p53 expression whereas TFIIS knockdown in the noncancerous breast cell line MCF10A was less affected. Differential effects of TFIIS knockdown in MCF7 and MCF10A cells included the estrogenic, c-myc and p53 pathways, as observed by C-ELISA and gene array, and were likely involved in MCF7 cell-death. Conclusion: Although transcription is a fundamental process, targeting select core transcription factors may provide for a new and potent avenue for cancer therapeutics. In the present study, knockdown of TFIIS inhibited cancer cell proliferation, suggesting that TFIIS could be studied as a potential cancer target within the transcription machinery. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE silencing
KW - RNA
KW - TRANSCRIPTION factors
KW - CANCER cells -- Proliferation
KW - APOPTOSIS
N1 - Accession Number: 35704001; Hubbard, Kyle 1; Email Address: hubbard.kyle@gmail.com Catalano, Jennifer 2; Email Address: jennifer.catalano@fda.hhs.gov Puri, Raj K. 2; Email Address: raj.puri@fda.hhs.gov Gnatt, Averell 1,3; Email Address: agnat001@umaryland.edu; Affiliation: 1: Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, 21201, USA 2: Center for Biologics and Evaluation Research, United States Food and Drug Administration, Bethesda, MD, 20892, USA 3: Marlene and Stewart Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD, 21201, USA; Source Info: 2008, Vol. 8, Special section p1; Subject Term: GENE silencing; Subject Term: RNA; Subject Term: TRANSCRIPTION factors; Subject Term: CANCER cells -- Proliferation; Subject Term: APOPTOSIS; Number of Pages: 16p; Illustrations: 3 Diagrams, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1186/1471-2407-8-133
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35704001&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ketha, Krishna Mohan V.
AU - Atreya, Chintamani D.
T1 - Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of Influenza A virus strain.
JO - BMC Cell Biology
JF - BMC Cell Biology
Y1 - 2008/01//
VL - 9
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712121
AB - Background: Two nuclear localization sequences (NLS) in influenza A virus nucleoprotein (NP) have been demonstrated to be critical for nuclear import of NP and viral ribonucleoprotein complexes. However, a deletion mutant lacking these two signals was still able to localize to the nucleus suggesting the presence of yet another (a third) potential NLS in the NP protein. In order to identify the nature of this potential NLS signal in the NP of a WS/33L influenza virus A strain, we utilized the tools of bioinformatics coupled with functional experimental analyses in the present study. Results: Comparison of the deduced aa sequence of NP of WS/33L strain with the published WS/ 33 NP sequences revealed that a single amino acid (aa) change (Met to Arg) at position 105 results in converting the flanking regions (between aa position 90-121, a 32-residue stretch) into two classical overlapping bipartite NLS (obpNLS). GenBank search revealed that 9 out of 500 published NP sequences contain a similar Arg at position 105 (instead of Met) with a 100% homology to the obpNLS region. Various NP-green fluorescent protein (GFP) fusion constructs with and without the signal (obpNLS-Arg105) were utilized to understand the functional nature of this signal. We analyzed the transport competency of the expressed chimeric proteins in terms of their cellular localization by confocal immunofluorescence assay. Our analysis revealed that all NP-GFP constructs containing the wild-type (R105) sequence localized predominantly to the nucleus. Constructs lacking the obpNLS or constructs with reverse mutation (R105 to M105) on the other hand exhibited predominant cytoplasmic localization pattern. Interestingly, when the 32 aa obpNLS was fused with an unrelated viral protein (rotavirus NSP6) that has been known to be cytoplasmic protein, the chimeric protein (obpNLS-NSP6) was efficiently transported into the nucleus, indicating an efficient nuclear transport function of the 32-residue obpNLS in the NP of WS/33L strain of influenza A virus. Conclusion: This report while not only establishing a new NLS in the influenza A virus strain, it also reinforces the idea that proper application of bioinformatics-coupled experimental analysis serves as a powerful tool in identifying new functional signals in proteins of interest. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Cell Biology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA A virus
KW - INFLUENZA viruses
KW - NUCLEOPROTEINS
KW - BIOINFORMATICS
KW - GREEN fluorescent protein
KW - FLUORESCENT polymers
KW - IMMUNOFLUORESCENCE
N1 - Accession Number: 35701472; Ketha, Krishna Mohan V. 1; Email Address: krishna.ketha@fda.hhs.gov Atreya, Chintamani D. 1; Email Address: chintamani.atreya@fd.hhs.gov; Affiliation: 1: Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (F.D.A.) Bethesda, MD 20892, USA; Source Info: 2008, Vol. 9, Special section p1; Subject Term: INFLUENZA A virus; Subject Term: INFLUENZA viruses; Subject Term: NUCLEOPROTEINS; Subject Term: BIOINFORMATICS; Subject Term: GREEN fluorescent protein; Subject Term: FLUORESCENT polymers; Subject Term: IMMUNOFLUORESCENCE; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 3 Color Photographs, 1 Black and White Photograph, 3 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1186/1471-2121-9-22
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arikawa, Emi
AU - Yanyang Sun
AU - Jie Wang
AU - Qiong Zhou
AU - Baitang Ning
AU - Dial, Stacey L.
AU - Lei Guo
AU - Jingping Yang
T1 - Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2008/01//
VL - 9
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712164
AB - Background: The MicroArray Quality Control (MAQC) project evaluated the inter- and intraplatform reproducibility of seven microarray platforms and three quantitative gene expression assays in profiling the expression of two commercially available Reference RNA samples (Nat Biotechnol 24:1115-22, 2006). The tested microarrays were the platforms from Affymetrix, Agilent Technologies, Applied Biosystems, GE Healthcare, Illumina, Eppendorf and the National Cancer Institute, and quantitative gene expression assays included TaqMan® Gene Expression PCR Assay, Standardized (Sta) RT-PCR™ and QuantiGene®. The data showed great consistency in gene expression measurements across different microarray platforms, different technologies and test sites. However, SYBR® Green real-time PCR, another common technique utilized by half of all real-time PCR users for gene expression measurement, was not addressed in the MAQC study. In the present study, we compared the performance of SYBR Green PCR with TaqMan PCR, microarrays and other quantitative technologies using the same two Reference RNA samples as the MAQC project. We assessed SYBR Green real-time PCR using commercially available RT2 Profiler™ PCR Arrays from SuperArray, containing primer pairs that have been experimentally validated to ensure gene-specificity and high amplification efficiency. Results: The SYBR Green PCR Arrays exhibit good reproducibility among different users, PCR instruments and test sites. In addition, the SYBR Green PCR Arrays have the highest concordance with TaqMan PCR, and a high level of concordance with other quantitative methods and microarrays that were evaluated in this study in terms of fold-change correlation and overlap of lists of differentially expressed genes. Conclusion: These data demonstrate that SYBR Green real-time PCR delivers highly comparable results in gene expression measurement with TaqMan PCR and other high-density microarrays. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - POLYMERASE chain reaction
KW - BIOLOGICAL assay
KW - GENE expression
KW - RNA
N1 - Accession Number: 38122918; Arikawa, Emi 1; Email Address: earikawa@superarray.net Yanyang Sun 1; Email Address: ysun@superarray.net Jie Wang 1; Email Address: jwang@superarray.net Qiong Zhou 1; Email Address: qzhou257@hotmail.com Baitang Ning 2; Email Address: baitang.ning@fda.hhs.gov Dial, Stacey L. 2; Email Address: stacey.dial@fda.hhs.gov Lei Guo 2; Email Address: lei.guo@fda.hhs.gov Jingping Yang 1; Email Address: jpyang@superarray.net; Affiliation: 1: SuperArray Bioscience Corporation, Frederick, MD 21704, USA 2: National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: 2008, Vol. 9, Special section p1; Subject Term: DNA microarrays; Subject Term: POLYMERASE chain reaction; Subject Term: BIOLOGICAL assay; Subject Term: GENE expression; Subject Term: RNA; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 12p; Document Type: Article
L3 - 10.1186/1471-2164-9-328
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sharma, Anuj
AU - Bhattacharya, Bhaskar
AU - Puri, Raj K.
AU - Maheshwari, Radha K.
T1 - Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2008/01//
VL - 9
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 14712164
AB - Background: Neurovirulent Venezuelan equine encephalitis virus (VEEV) causes lethal encephalitis in equines and is transmitted to humans by mosquitoes. VEEV is highly infectious when transmitted by aerosol and has been developed as a bio-warfare agent, making it an important pathogen to study from a military and civilian standpoint. Molecular mechanisms of VEE pathogenesis are poorly understood. To study these, the gene expression profile of VEEV infected mouse brains was investigated. Changes in gene expression were correlated with histological changes in the brain. In addition, a molecular framework of changes in gene expression associated with progression of the disease was studied. Results: Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection. The number of over-expressed genes (>1.5-fold level) increased as the disease progressed (from 197, 296, 400, to 1086 at 24, 48, 72 and 96 hours post infection, respectively). Conclusion: Identification of differentially expressed genes in brain will help in the understanding of VEEV-induced pathogenesis and selection of biomarkers for diagnosis and targeted therapy of VEEV-induced neurodegeneration. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EQUINE encephalomyelitis
KW - HORSES -- Virus diseases
KW - GENE expression
KW - ANTIGENS
KW - INFLAMMATION
KW - APOPTOSIS
KW - IMMUNITY
N1 - Accession Number: 38122874; Sharma, Anuj 1,2; Email Address: asharma@usuhs.mil Bhattacharya, Bhaskar 3; Email Address: bhaskar.bhattacharya@fda.hhs.gov Puri, Raj K. 3; Email Address: raj.puri@fda.hhs.gov Maheshwari, Radha K. 1; Email Address: rmaheshwari@usuhs.mil; Affiliation: 1: Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA 2: Biological Sciences Group, Birla Institute of Technology and Science, Pilani, India 3: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA; Source Info: 2008, Vol. 9, Special section p1; Subject Term: EQUINE encephalomyelitis; Subject Term: HORSES -- Virus diseases; Subject Term: GENE expression; Subject Term: ANTIGENS; Subject Term: INFLAMMATION; Subject Term: APOPTOSIS; Subject Term: IMMUNITY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1186/1471-2164-9-289
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petersen, Martin R.
AU - Deddens, James A.
T1 - A comparison of two methods for estimating prevalence ratios.
JO - BMC Medical Research Methodology
JF - BMC Medical Research Methodology
Y1 - 2008/01//
VL - 8
M3 - Article
SP - 1
EP - 9
PB - BioMed Central
SN - 14712288
AB - Background: It is usually preferable to model and estimate prevalence ratios instead of odds ratios in cross-sectional studies when diseases or injuries are not rare. Problems with existing methods of modeling prevalence ratios include lack of convergence, overestimated standard errors, and extrapolation of simple univariate formulas to multivariable models. We compare two of the newer methods using simulated data and real data from SAS online examples. Methods: The Robust Poisson method, which uses the Poisson distribution and a sandwich variance estimator, is compared to the log-binomial method, which uses the binomial distribution to obtain maximum likelihood estimates, using computer simulations and real data. Results: For very high prevalences and moderate sample size, the Robust Poisson method yields less biased estimates of the prevalence ratios than the log-binomial method. However, for moderate prevalences and moderate sample size, the log-binomial method yields slightly less biased estimates than the Robust Poisson method. In nearly all cases, the log-binomial method yielded slightly higher power and smaller standard errors than the Robust Poisson method. Conclusion: Although the Robust Poisson often gives reasonable estimates of the prevalence ratio and is very easy to use, the log-binomial method results in less bias in most common situations, and because it fits the correct model and obtains maximum likelihood estimates, it generally results in slightly higher power, smaller standard errors, and, unlike the Robust Poisson, it always yields estimated prevalences between zero and one. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Medical Research Methodology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research -- Methodology
KW - DISEASE prevalence
KW - MEDICAL informatics
KW - POISSON distribution
KW - BINOMIAL distribution
KW - RESEARCH bias
N1 - Accession Number: 35702240; Petersen, Martin R. 1; Email Address: mrp1@cdc.gov Deddens, James A. 1,2; Email Address: jad0@cdc.gov; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Mail Stop R15 4676 Columbia Parkway Cincinnati, OH 45226, USA 2: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio, USA; Source Info: 2008, Vol. 8, Special section p1; Subject Term: MEDICAL research -- Methodology; Subject Term: DISEASE prevalence; Subject Term: MEDICAL informatics; Subject Term: POISSON distribution; Subject Term: BINOMIAL distribution; Subject Term: RESEARCH bias; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1186/1471-2288-8-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105218723
T1 - A comparison of two methods for estimating prevalence ratios.
AU - Petersen MR
AU - Deddens JA
Y1 - 2008/01//
N1 - Accession Number: 105218723. Language: English. Entry Date: 20100709. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 100968545.
KW - Cross Sectional Studies
KW - Models, Statistical
KW - Prevalence
KW - Analysis of Variance
KW - Computer Simulation
KW - Probability
KW - Logistic Regression
KW - Poisson Distribution
SP - 9
EP - 9
JO - BMC Medical Research Methodology
JF - BMC Medical Research Methodology
JA - BMC MED RES METHODOL
VL - 8
PB - BioMed Central
SN - 1471-2288
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Mail Stop R15 4676 Columbia Parkway Cincinnati, OH 45226, USA. mrp1@cdc.gov
U2 - PMID: 18307814.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jansen, Wilma
AU - Raat, Hein
AU - Zwanenburg, Evelien Joosten-van
AU - Reuvers, Ivo
AU - van Walsem, Ron
AU - Brug, Johannes
T1 - A school-based intervention to reduce overweight and inactivity in children aged 6-12 years: study design of a randomized controlled trial.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2008/01//
VL - 8
IS - 1
M3 - Article
SP - 257
EP - 265
PB - BioMed Central
SN - 14712458
AB - Background: Effective interventions to prevent overweight and obesity in children are urgently needed especially in inner-city neighbourhoods where prevalence of overweight and inactivity among primary school children is high. A school based intervention was developed aiming at the reduction of overweight and inactivity in these children by addressing both behavioural and environmental determinants. Methods/design: The main components of the intervention (Lekker Fit!) are the re-establishment of a professional physical education teacher; three (instead of two) PE classes per week; additional sport and play activities outside school hours; fitness testing; classroom education on healthy nutrition, active living and healthy lifestyle choices; and the involvement of parents. The effectiveness of the intervention is evaluated through a cluster randomized controlled trial in 20 primary schools among grades 3 through 8 (6-12 year olds). Primary outcome measures are BMI, waist circumference and fitness. Secondary outcome measures are assessed in a subgroup of grade 6-8 pupils (9-12 year olds) through classroom questionnaires and constitute of nutrition and physical activity behaviours and behavioural determinants. Multilevel regression analyses are used to study differences in outcomes between children in the intervention schools and in control schools, taking clustering of children within schools into account. Discussion: Hypotheses are that the intervention results in a lower prevalence of children being overweight and an improved mean fitness score, in comparison with a control group where the intervention is not implemented. The results of our study will contribute to the discussion on the role of physical education and physical activity in the school curriculum. Trial registration: [ISRCTN84383524] [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY
KW - PHYSICAL fitness testing
KW - CHILDREN
KW - CLINICAL trials
KW - NUTRITION disorders
N1 - Accession Number: 51486053; Jansen, Wilma 1,2; Email Address: jansenw@ggd.rotterdam.nl Raat, Hein 1; Email Address: h.raat@erasmusmc.nl Zwanenburg, Evelien Joosten-van 2; Email Address: ejoosten@ggdzhz.nl Reuvers, Ivo 3; Email Address: i.reuvers@senr.rotterdam.nl van Walsem, Ron 3; Email Address: r.vanwalsem@senr.rotterdam.nl Brug, Johannes 1,4; Email Address: j.brug@vumc.nl; Affiliation: 1: Department of Public Health, Erasmus MC, Rotterdam, The Netherlands. 2: Rotterdam Public Health Service and Environs, Rotterdam, The Netherlands. 3: Municipal Sport and Recreation Department, Rotterdam, The Netherlands. 4: EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands.; Source Info: 2008, Vol. 8 Issue 1, p257; Subject Term: OBESITY; Subject Term: PHYSICAL fitness testing; Subject Term: CHILDREN; Subject Term: CLINICAL trials; Subject Term: NUTRITION disorders; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pandolfi, Elisabetta
AU - Graziani, Maria C.
AU - Ieraci, Roberto
AU - Cavagni, Giovanni
AU - Tozzi, Alberto E.
T1 - A comparison of populations vaccinated in a public service and in a private hospital setting in the same area.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2008/01//
VL - 8
IS - 1
M3 - Article
SP - 278
EP - 285
PB - BioMed Central
SN - 14712458
AB - Background: Improving immunisation rates in risk groups is one of the main objectives in vaccination strategies. However, achieving high vaccination rates in children with chronic conditions is difficult. Different types of vaccine providers may differently attract high risk children. Aim: To describe the characteristics of two populations of children who attended a private and a public immunisation provider in the same area. Secondarily, to determine if prevalence of patients with underlying diseases by type of provider differs and to study if the choice of different providers influences timeliness in immunisation. Methods: We performed a cross-sectional study on parents of children 2 - 36 months of age who attended a private hospital immunisation service or a public immunisation office serving the same metropolitan area of Rome, Italy. Data on personal characteristics and immunisation history were collected through a face to face interview with parents of vaccinees, and compared by type of provider. Prevalence of underlying conditions was compared in the two populations. Timeliness in immunisation and its determinants were analysed through a logistic regression model. Results: A total of 202 parents of children 2-36 months of age were interviewed; 104 were in the public office, and 98 in the hospital practice. Children immunised in the hospital were more frequently firstborn female children, breast fed for a longer period, with a lower birthweight, and more frequently with a previous hospitalisation. The prevalence of high risk children immunised in the hospital was 9.2 vs 0% in the public service (P = 0.001). Immunisation delay for due vaccines was higher in the hospital practice than in the public service (DTP, polio, HBV, and Hib: 39.8% vs 22.1%; P = 0.005). Anyway multivariate analyses did not reveal differences in timeliness between the public and private hospital settings. Conclusion: Children with underlying diseases or a low birthweight were more frequently immunised in the hospital. This finding suggests that offering immunisations in a hospital setting may facilitate vaccination uptake in high risk groups. An integration between public and hospital practices and an effort to improve communication on vaccines to parents, may significantly increase immunisation rates in high risk groups and in the general population, and prevent immunisation delays. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREVENTIVE medicine
KW - VACCINES
KW - DECISION making
KW - BREASTFEEDING (Humans)
KW - HOSPITAL care
KW - ITALY
N1 - Accession Number: 51486024; Pandolfi, Elisabetta 1; Email Address: pandolfi.elisabetta@gmail.com Graziani, Maria C. 1; Email Address: graziani@opbg.net Ieraci, Roberto 2; Email Address: r.ieraci@alice.it Cavagni, Giovanni 1; Email Address: cavagni@opbg.net Tozzi, Alberto E. 1; Email Address: alberto.tozzi@opbg.net; Affiliation: 1: Bambino Gesù Pediatric Hospital, Rome, Italy. 2: RME Public Health Service, Rome, Italy.; Source Info: 2008, Vol. 8 Issue 1, p278; Subject Term: PREVENTIVE medicine; Subject Term: VACCINES; Subject Term: DECISION making; Subject Term: BREASTFEEDING (Humans); Subject Term: HOSPITAL care; Subject Term: ITALY; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leurs, Mariken T. W.
AU - Mur-Veeman, Ingrid M.
AU - van der Sar, Rosalie
AU - Schaalma, Herman P.
AU - de^Vries, Nanne K.
T1 - Diagnosis of sustainable collaboration in health promotion - a case study.
JO - BMC Public Health
JF - BMC Public Health
Y1 - 2008/01//
VL - 8
IS - 1
M3 - Article
SP - 382
EP - 396
PB - BioMed Central
SN - 14712458
AB - Background: Collaborations are important to health promotion in addressing multi-party problems. Interest in collaborative processes in health promotion is rising, but still lacks monitoring instruments. The authors developed the DIagnosis of Sustainable Collaboration (DISC) model to enable comprehensive monitoring of public health collaboratives. The model focuses on opportunities and impediments for collaborative change, based on evidence from interorganizational collaboration, organizational behavior and planned organizational change. To illustrate and assess the DISC-model, the 2003/2004 application of the model to the Dutch whole-school health promotion collaboration is described. Methods: The study combined quantitative research, using a cross-sectional survey, with qualitative research using the personal interview methodology and document analysis. A DISC-based survey was sent to 55 stakeholders in whole-school health promotion in one Dutch region. The survey consisted of 22 scales with 3 to 8 items. Only scales with a reliability score of 0.60 were accepted. The analysis provided for comparisons between stakeholders from education, public service and public health. The survey was followed by approaching 14 stakeholders for a semi-structured DISC-based interview. As the interviews were timed after the survey, the interviews were used to clarify unexpected and unclear outcomes of the survey as well. Additionally, a DISC-based document analysis was conducted including minutes of meetings, project descriptions and correspondence with schools and municipalities. Results: Response of the survey was 77% and of the interviews 86%. Significant differences between respondents of different domains were found for the following scales: organizational characteristics scale, the change strategies, network development, project management, willingness to commit and innovative actions and adaptations. The interviews provided a more specific picture of the state of the art of the studied collaboration regarding the DISC-constructs. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Public Health is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - PUBLIC health research
KW - QUANTITATIVE research
KW - HEALTH surveys
KW - MEDICAL care surveys
KW - MUNICIPAL government
KW - INTERVIEWS
N1 - Accession Number: 51491783; Leurs, Mariken T. W. 1,2; Email Address: marikenjustin@hotmail.com Mur-Veeman, Ingrid M. 3; Email Address: i.mur@beoz.unimaas.nl van der Sar, Rosalie 2,4; Email Address: rosalievandersar@hotmail.com Schaalma, Herman P. 5; Email Address: herman.schaalma@psychology.unimaas.nl de^Vries, Nanne K. 6; Email Address: n.devries@gvo.unimaas.nl; Affiliation: 1: Youth Department, Netherlands Organization for Health Research and Development, P.O. Box 93245; 2509 AE The Hague, The Netherlands. 2: Regional Public Health Service Maastricht, The Netherlands. 3: Health Policy and Economics Department, University Maastricht, PO Box 616, 6400 MD Maastricht, The Netherlands. 4: Health Promotion Department, Netherlands Organization for Health Research and Development P.O. Box 93245; 2509 AE The Hague, The Netherlands. 5: Psychology Faculty, University Maastricht, PO Box 616, 6400 MD Maastricht, The Netherlands. 6: Health Promotion Department, University Maastricht, PO Box 616, 6400 MD Maastricht, The Netherlands.; Source Info: 2008, Vol. 8 Issue 1, p382; Subject Term: HEALTH promotion; Subject Term: PUBLIC health research; Subject Term: QUANTITATIVE research; Subject Term: HEALTH surveys; Subject Term: MEDICAL care surveys; Subject Term: MUNICIPAL government; Subject Term: INTERVIEWS; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 15p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105756504
T1 - The changing epidemiology of tuberculosis and the BCG vaccination programme.
AU - Porter-Jones G
AU - Roberts R
Y1 - 2008/01//Jan/Feb2008
N1 - Accession Number: 105756504. Language: English. Entry Date: 20080704. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Europe; Nursing; Peer Reviewed; UK & Ireland. Special Interest: Pediatric Care; Public Health. NLM UID: 101297722.
KW - BCG Vaccine -- Administration and Dosage -- United Kingdom
KW - Health Policy -- Trends -- United Kingdom
KW - School Health
KW - Tuberculosis -- Epidemiology -- United Kingdom
KW - Tuberculosis -- Prevention and Control -- United Kingdom
KW - Adolescence
KW - Child
KW - Nursing Role
KW - School Health Nursing
KW - United Kingdom
SP - 15
EP - 19
JO - British Journal of School Nursing
JF - British Journal of School Nursing
JA - BR J SCH NURS
VL - 3
IS - 1
PB - Mark Allen Holdings Limited
SN - 1752-2803
AD - Health Protection Nurse for the Health Protection Team of the National Public Health Service for Wales, UK; gary.porter-jones@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Frías, Inmaculada
AU - Rubio, Carmen
AU - González-Iglesias, Tomás
AU - Gutiérrez, Ángel
AU - González-Weller, Dailos
AU - Hardisson, Arturo
T1 - “Metals in Fresh Honeys from Tenerife Island, Spain”.
JO - Bulletin of Environmental Contamination & Toxicology
JF - Bulletin of Environmental Contamination & Toxicology
Y1 - 2008/01//
VL - 80
IS - 1
M3 - Article
SP - 30
EP - 33
PB - Springer Science & Business Media B.V.
SN - 00074861
AB - Ashes and contents of Zn, Cu, Fe, Cd and Pb in 140 fresh honey samples from three different areas of Tenerife Island were determined by inductively coupled plasma atomic emission spectrometry and graphite furnace atomic absorption spectrometry. A mean ash content of 0.35% has been determined. The mean Fe, Cu, Zn, Pb and Cd concentrations observed have been 3.37 mg kg−1, 1.28 mg kg−1, 2.83 mg kg−1, 37.33 μg kg−1, 4.38 μg kg−1, respectively. A direct statistical correlation has been found between the Fe–Zn and Fe–Pb content, and between the Cd–Zn and Cd–Pb levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bulletin of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Honey
KW - Metals
KW - Iron
KW - Zinc
KW - Lead
KW - Cadmium
KW - Copper
KW - Inductively coupled plasma atomic emission spectrometry
KW - Furnace atomic absorption spectroscopy
KW - Ash (Combustion product)
KW - Tenerife (Canary Islands)
KW - Canary Islands
KW - Essential metals
KW - Toxic metals
N1 - Accession Number: 28329041; Frías, Inmaculada 1; Rubio, Carmen 1; González-Iglesias, Tomás 2; Gutiérrez, Ángel 1; González-Weller, Dailos 1; Email Address: dgonzal@ull.es; Hardisson, Arturo 1; Affiliations: 1: Department of Toxicology , University of La Laguna , La Laguna, Tenerife 38071 Spain; 2: Canarian Public Health Service , Santa Cruz de Tenerife, Tenerife 38006 Spain; Issue Info: Jan2008, Vol. 80 Issue 1, p30; Thesaurus Term: Honey; Thesaurus Term: Metals; Thesaurus Term: Iron; Thesaurus Term: Zinc; Thesaurus Term: Lead; Thesaurus Term: Cadmium; Thesaurus Term: Copper; Subject Term: Inductively coupled plasma atomic emission spectrometry; Subject Term: Furnace atomic absorption spectroscopy; Subject Term: Ash (Combustion product); Subject: Tenerife (Canary Islands); Author-Supplied Keyword: Canary Islands; Author-Supplied Keyword: Essential metals; Author-Supplied Keyword: Toxic metals; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 332811 Metal Heat Treating; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1007/s00128-007-9301-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lane, Jason W.
AU - Rehak, Nadja N.
AU - Hortin, Glen L.
AU - Zaoutis, Theoklis
AU - Krause, Philip R.
AU - Walsh, Thomas J.
T1 - Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 2008/01//
VL - 387
IS - 1/2
M3 - Article
SP - 145
EP - 149
SN - 00098981
AB - Abstract: Background: Acute increases in serum inorganic phosphorus (Pi) up to 4.75 mmol/l in the absence of hypocalcemia and tissue deposition of calcium phosphate were noted in 3 patients receiving liposomal amphotericin B (L-AMB). We investigated L-AMB as a possible cause of pseudohyperphosphatemia. Methods: Serum samples from the index patient were analyzed for Pi content by our laboratory''s primary analyzer (Synchron LX20) and by an alternate analyzer (Vitros). Clear and lipemic serum pools, and normal saline, were spiked with L-AMB and analyzed by the LX20 Pi method. Ultrafiltration studies were performed on patient and spiked sera. Results: Increased Pi values were obtained only from the LX20 analyzer. There was a direct linear relationship between the concentration of L-AMB in the spiked samples and the LX20 Pi results, indicating a 0.9 mmol/l Pi increase for every 100 mg/l increase in L-AMB. Ultrafiltration normalized the Pi results. Conclusion: Serum Pi results may be falsely increased in patients receiving L-AMB when measured by the LX20 analyzer. This novel cause of pseudohyperphosphatemia is due to interference of L-AMB with the method and is corrected by ultrafiltration of the specimen. Since the LX20 analyzer is widely used by the clinical laboratories clinicians and laboratory personnel should recognize this interference in order to avoid unnecessary diagnostic procedures and interventions. [Copyright &y& Elsevier]
AB - Copyright of Clinica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMPHOTERICIN B
KW - HYPOCALCEMIA
KW - BLOOD plasma
KW - CALCIUM metabolism disorders
KW - inorganic phosphorus. ( Pi )
KW - liposomal amphotericin B ( L-AMB )
KW - Liposomal amphotericin B (L-AMB)
KW - maximum concentration of drug in plasma ( C max )
KW - mean area under the concentration–time curve from 0 to 24 h ( AUC24 )
KW - Pseudohyperphosphatemia
KW - Synchron LX20
N1 - Accession Number: 27446649; Lane, Jason W. 1 Rehak, Nadja N. 2; Email Address: nrehak@cc.nih.gov Hortin, Glen L. 2 Zaoutis, Theoklis 3,4,5 Krause, Philip R. 6 Walsh, Thomas J. 7; Affiliation: 1: Microbiology Service, Department of Laboratory Medicine, W. G. Magnuson Clinical Center, NIH, Bethesda, Maryland, USA 2: Clinical Chemistry Service, Department of Laboratory Medicine, W. G. Magnuson Clinical Center, NIH, Bethesda, Maryland, USA 3: Division of Infectious Diseases, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 4: Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 5: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 6: Food and Drug Administration, Bethesda, Maryland, USA 7: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA; Source Info: Jan2008, Vol. 387 Issue 1/2, p145; Subject Term: AMPHOTERICIN B; Subject Term: HYPOCALCEMIA; Subject Term: BLOOD plasma; Subject Term: CALCIUM metabolism disorders; Author-Supplied Keyword: inorganic phosphorus. ( Pi ); Author-Supplied Keyword: liposomal amphotericin B ( L-AMB ); Author-Supplied Keyword: Liposomal amphotericin B (L-AMB); Author-Supplied Keyword: maximum concentration of drug in plasma ( C max ); Author-Supplied Keyword: mean area under the concentration–time curve from 0 to 24 h ( AUC24 ); Author-Supplied Keyword: Pseudohyperphosphatemia; Author-Supplied Keyword: Synchron LX20; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.cca.2007.08.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27446649&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
TY - GEN
AU - Clark, PT;
AU - Levin, S;
T1 - The smallpox vaccine injury compensation program
CT - The smallpox vaccine injury compensation program
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/01/01/
VL - 46
IS - MAR 15
SP - S179
EP - S181
SN - 10584838
AD - US Dept HHS, HRSA, Parklawn Bldg, Rm 11C-06, 5600 Fishers Ln, Rockville, MD 20857, USA TOverby@hrsa.gov
N1 - Accession Number: 45-11956; Language: English; Chemical Name: Smallpox vaccines--0; Therapeutic Class: (80:12); AHFS Class: Vaccines Smallpox vaccines; References: 6; Journal Coden: CINFDE; Human Indicator: Yes; Section Heading: Sociology, Economics and Ethics; Pharmacology
N2 - In January 2003, the Secretary of the US Department of Health and Human Services (DHHS) announced that certain individuals should receive smallpox vaccine or other countermeasures to be prepared to serve the civilian population in the event of a smallpox bioterrorism event. In April 2003, Congress passed and the President signed the Smallpox Emergency Personnel Protection Act of 2003. This act created the Smallpox Vaccine Injury Compensation Program to provide medical and lost employment income coverage as a payer of last resort to persons who sustain a covered medical injury as a direct result of receiving smallpox vaccination voluntarily under a DHHS-approved smallpox emergency response plan. As of September 2006, 62 persons had requested benefits, of whom 19 had been determined to be medically eligible, 21 were denied benefits, and 16 submitted the request after the legislatively defined filing deadline.
KW - Smallpox vaccines--immunogenicity-;
KW - Immunogenicity--smallpox vaccines;
KW - Smallpox--immunization;
KW - Immunization--smallpox;
KW - Vaccines--smallpox;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 105896601
T1 - A survey of quality indicator use in the clinical laboratory.
AU - Preston LJ
Y1 - 2008///Winter2008
N1 - Accession Number: 105896601. Language: English. Entry Date: 20080425. Revision Date: 20150820. Publication Type: Journal Article; questionnaire/scale; research; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis; Quality Assurance. NLM UID: 8806547.
KW - Benchmarking
KW - Clinical Indicators
KW - Clinical Laboratories -- Arizona
KW - Arizona
KW - Correlation Coefficient
KW - Proficiency Testing, Laboratory
KW - Quality Assurance
KW - Questionnaires
KW - Surveys
KW - T-Tests
KW - Human
SP - 25
EP - 32
JO - Clinical Laboratory Science
JF - Clinical Laboratory Science
JA - CLIN LAB SCI
VL - 21
IS - 1
CY - Tysons Corner, Virginia
PB - American Society for Clinical Laboratory Science
AB - OBJECTIVE: A survey of clinical laboratories was conducted to capture information about quality indicators in use within the state of Arizona. This information was then used to determine which quality indicators are applicable across the spectrum of clinical laboratories making them suitable for benchmarking laboratory performance. The objectives of this study were also to heighten awareness of benchmarking practices for clinical laboratory managers and laboratory quality assurance personnel, to develop objective methods of quality monitoring for performance improvement, and to encourage collaboration between laboratories and accreditation agencies. METHODS: A review of the current literature was conducted to assess the status of benchmarking within the clinical laboratory. Data were also obtained from the Centers for Medicare & Medicaid Services (CMS) about all licensed clinical laboratories in Arizona. A mail survey was then created and conducted to investigate the use of clinical laboratory quality indicators in Arizona. SETTING AND PARTICIPANTS: A paper survey was mailed to a representative sample of clinical laboratory managers included in the CMS licensed laboratories listing for the state of Arizona. MAIN OUTCOME MEASURES: The selected sample was surveyed by mail and validation testing of the survey was conducted using the t-test. The compiled survey data is also presented in the form of histograms. RESULTS: Applying the t-test to the sample vs. population data proved that the sample was not a very good representation of the population and a better selection method should be used in future studies. Of the 319 of 3198 clinical laboratories randomly selected to receive the survey, 21 (6.58% of the sample or 0.66% of the population) responded with completed surveys. The information received from the respondents revealed a relationship between test volume and the number of indicators being monitored by clinical laboratories, the preference of indicators being monitored by those laboratories, the size of the laboratories where the majority of benchmarking is occurring, and a link between accrediting agencies and benchmarking activities. CONCLUSION: The survey proved that quality indicators are used for quality improvement purposes within the clinical laboratory; although it also showed that the industry still does not have a standardized approach to the use of quality indicators for benchmarking performance against other laboratories.
SN - 0894-959X
AD - US Public Health Service (PHS) Indian Health Service, Hopi Health Care Center, Keams Canyon, AZ
U2 - PMID: 18335858.
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DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2008-19321-016
AN - 2008-19321-016
AU - Bowyer, John F.
AU - Thomas, Monzy
AU - Schmued, Larry C.
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Kuhar, Michael J.
ED - Ali, Syed F., (Ed)
ED - Kuhar, Michael J., (Ed)
T1 - Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier.
T2 - Drug addiction: Research frontiers and treatment advances.
T3 - Annals of the New York Academy of Sciences; Vol 1139; ISSN: 0077-8923 (Print)
Y1 - 2008///
VL - 1139
SP - 127
EP - 139
CY - Malden, MA, US
PB - Blackwell Publishers
SN - 0077-8923
SN - 1-57331-718-7
SN - 978-1-57331-718-4
AD - Bowyer, John F., Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US, 72079
N1 - Accession Number: 2008-19321-016. Partial author list: First Author & Affiliation: Bowyer, John F.; Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20091026. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-718-7, Paperback; 978-1-57331-718-4, Paperback. Language: English. Major Descriptor: Amphetamine; Brain; Hyperthermia; Methamphetamine. Minor Descriptor: Amygdala; Blood; Hippocampus; Mice; Neurotoxicity; Rats; Seizures; Thalamic Nuclei. Classification: Neuropsychology & Neurology (2520). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13.
AB - Understanding the neurotoxic effects of acute high-dose exposures of laboratory animals to methamphetamine (METH) and amphetamine (AMPH) is of relevance to understanding the neurotoxicity incurred in humans from overdose or abuse of these substances. We present recent findings on the neurodegenerative effects of both a single high dose of 40 mg/kg and a 4-dose exposure to AMPH in the rat. Comparing these results with those we have previously observed in rodents exposed to either AMPH or METH helps further address how dose, hyperthermia, seizures and blood-brain barrier (BBB) disruption interact to produce neurodegeneration. With regard to the 4-dose paradigm of AMPH exposure in the rat, our recent data, combined with previous findings, clearly show the importance of dose and hyperthermic interactions in producing neurodegeneration. The single high AMPH dose invariably resulted in extreme hyperthermia and brief episodes of clonic-tonic seizure activity in many rats. However, motor behavior indicative of status epilepticus was not observed in rats receiving the 40 mg/kg AMPH, which contrasts with what we have previously seen with 40 mg/kg METH dose in the mouse. This may explain why, unlike the mice given METH, there was minimal BBB disruption in the amygdala of rats. Nonetheless, in some of the surviving rats there was extensive neurodegeneration in the hippocampus and intralaminar and ventromedial/ lateral thalamic nuclei. Early BBB disruption was seen in the hippocampus and may play an important role in the subsequent neurodegeneration. The fact that status epilepticus does not occur in rats that have major hippocampal and thalamic degeneration indicates that such damage may also occur in humans exposed to high doses of AMPH or METH in the absence of status epilepticus or prominent motor manifestations of seizure activity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - amphetamine
KW - blood-brain barrier disruption
KW - hyperthermia
KW - methamphetamine
KW - neurodegeneration
KW - brain
KW - rats
KW - seizures
KW - 2008
KW - Amphetamine
KW - Brain
KW - Hyperthermia
KW - Methamphetamine
KW - Amygdala
KW - Blood
KW - Hippocampus
KW - Mice
KW - Neurotoxicity
KW - Rats
KW - Seizures
KW - Thalamic Nuclei
KW - 2008
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-19321-019
AN - 2008-19321-019
AU - Wang, Jing
AU - Xu, Wenjing
AU - Ali, Syed F.
AU - Angulo, Jesus A.
ED - Ali, Syed F.
ED - Kuhar, Michael J.
ED - Ali, Syed F., (Ed)
ED - Kuhar, Michael J., (Ed)
T1 - Connection between the striatal neurokinin-1 receptor and nitric oxide formation during methamphetamine exposure.
T2 - Drug addiction: Research frontiers and treatment advances.
T3 - Annals of the New York Academy of Sciences; Vol 1139; ISSN: 0077-8923 (Print)
Y1 - 2008///
VL - 1139
SP - 164
EP - 171
CY - Malden, MA, US
PB - Blackwell Publishers
SN - 0077-8923
SN - 1-57331-718-7
SN - 978-1-57331-718-4
AD - Angulo, Jesus A., Hunter College, Department of Biological Sciences, 695 Park Avenue, New York, NY, US, 10065
N1 - Accession Number: 2008-19321-019. Partial author list: First Author & Affiliation: Wang, Jing; Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, US. Release Date: 20091026. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-718-7, Paperback; 978-1-57331-718-4, Paperback. Language: English. Grant Information: Angulo, Jesus A. Major Descriptor: Drug Usage; Methamphetamine; Neurobiology; Neurokinins. Minor Descriptor: Mice; Neurology; Nitric Oxide; Nitrogen; Somatostatin; Striatum; Visual Cortex. Classification: Neuropsychology & Neurology (2520); Substance Abuse & Addiction (3233). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8.
AB - Methamphetamine (METH) is a widely used 'club drug' that produces neural damage in the brain, including the loss of some neurons. METH-induced striatal neuronal loss has been attenuated by pretreatment with the neurokinin-1 receptor antagonist WIN- 51,708 in mice. Using a histologic method, we have observed the internalization of the neurokinin-1 receptor into endosomes in the striatal somatostatin/NPY/nitric oxide synthase interneurons. To investigate the role of this interneuron in the striatal cell death induced by METH, we assessed by immunohistochemistry the number of striatal nitric oxide synthase-positive neurons in the presence of METH at 8 and 16 hours after systemic injection of a bolus of METH (30 mg/kg, i.p.). We found the number of striatal nitric oxide synthase-positive neurons unchanged at these time points after METH. In a separate experiment we measured the levels of striatal 3-nitrotyrosine (3- NT) by HPLC (high-pressure liquid chromatography) as an indirect index of nitric oxide synthesis. METH increased the levels of 3-nitrotyrosine in the striatum and this increase was significantly attenuated by pretreatment with a selective neurokinin-1 receptor antagonist. These observations suggest a causal relationship between the neurokinin- 1 receptor and the activation of neuronal nitric oxide synthase that warrants further investigation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methamphetamine
KW - apoptosis
KW - 3-nitrotyrosine
KW - nitric oxide synthase
KW - neurokinin-1 receptor
KW - striatum
KW - mice
KW - 2008
KW - Drug Usage
KW - Methamphetamine
KW - Neurobiology
KW - Neurokinins
KW - Mice
KW - Neurology
KW - Nitric Oxide
KW - Nitrogen
KW - Somatostatin
KW - Striatum
KW - Visual Cortex
KW - 2008
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R01 DA020142. Recipients: Angulo, Jesus A.
U1 - Sponsor: Research Centers in Minority Institutions. Other Details: Hunter College. Recipients: No recipient indicated
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UR - anguio@genectr.hunter.cuny.edu
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-19321-029
AN - 2008-19321-029
AU - Sharma, Hari Shanker
AU - Ali, Syed F.
ED - Ali, Syed F.
ED - Kuhar, Michael J.
ED - Ali, Syed F., (Ed)
ED - Kuhar, Michael J., (Ed)
T1 - Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury: An experimental study in rats and mice using biochemical and morphologic approaches.
T2 - Drug addiction: Research frontiers and treatment advances.
T3 - Annals of the New York Academy of Sciences; Vol 1139; ISSN: 0077-8923 (Print)
Y1 - 2008///
VL - 1139
SP - 242
EP - 258
CY - Malden, MA, US
PB - Blackwell Publishers
SN - 0077-8923
SN - 1-57331-718-7
SN - 978-1-57331-718-4
AD - Sharma, Hari Shanker, Uppsala University, Frödingsgatan 12 28, SE, Uppsala, Sweden
N1 - Accession Number: 2008-19321-029. Partial author list: First Author & Affiliation: Sharma, Hari Shanker; Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, AR, US. Release Date: 20091026. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 1-57331-718-7, Paperback; 978-1-57331-718-4, Paperback. Language: English. Major Descriptor: Blood Brain Barrier; Hyperthermia; Methylenedioxymethamphetamine; Edema. Minor Descriptor: Brain; Cerebellum; Injuries; Metabolism; Neurotoxicity; Proteins; Rats; Stress. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17.
AB - The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, 'ecstasy') is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia that could lead to intense cellular stress and cause disruption of the blood-brain barrier(BBB), this investigation examined the effects of acute MDMA on BBB dysfunction,brain edema, and cell injury in rats and mice. When MDMA (40 mg/kg, i.p.) was administered to rats or mice, these animals exhibited profound behavioral disturbances(hyperactivity and hyperlocomotion) and hyperthermia (>40 to 41°C) at 4 h. At this time,the leakage of Evans blue dye was evident, particularly in the cerebellum, hippocampus,cortex, thalamus, and hypothalamus. This effect was most pronounced in mice compared to rats. Marked increase in brain water along with Na+ K+ and Cl- content was also seen in the aforementioned brain regions. Presence of distorted neuronal and glial cells in brain regions associated with leakage of Evans blue is quite common in MDMA-treated animals. Increased albumin immunoreactivity, indicating breakdown of the BBB, and upregulation of glial fibrillary acidic protein (GFAP), suggesting activation of astrocytes, were seen in most brain regions showing edematous changes. Upregulation of heat-shock protein (HSP72) immunoreactivity in the nuclei and cell cytoplasm of the neurons located in the edematous brain regions are quite common. Taken together,these observations are the first to show that MDMA has the capacity to disrupt BBB permeability to proteins and to induce the formation of edema, probably by inducing hyperthermia and cellular stress, as evident with HSP overexpression leading to cell injury. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - brain regions
KW - neurochemical metabolism
KW - cellular stress
KW - cell cytoplasm
KW - ecstasy
KW - blood-brain barrier
KW - brain edema
KW - serum albumin
KW - neuronal injury
KW - brain damage
KW - hyperthermia
KW - 2008
KW - Blood Brain Barrier
KW - Hyperthermia
KW - Methylenedioxymethamphetamine
KW - Edema
KW - Brain
KW - Cerebellum
KW - Injuries
KW - Metabolism
KW - Neurotoxicity
KW - Proteins
KW - Rats
KW - Stress
KW - 2008
U1 - Sponsor: Medical Research Council, Sweden. Grant: 2710 HSS. Recipients: No recipient indicated
U1 - Sponsor: Alexander Von Humboldt Foundation, Germany. Recipients: No recipient indicated
U1 - Sponsor: Astra-Zeneca, Sweden. Recipients: No recipient indicated
U1 - Sponsor: Acure Pharma, Sweden. Recipients: No recipient indicated
U1 - Sponsor: EbewePharma, Austria. Recipients: No recipient indicated
U1 - Sponsor: University Grant Commission, India. Recipients: No recipient indicated
U1 - Sponsor: Indian Council of Medical Research, India. Recipients: No recipient indicated
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UR - Sharma@surgsci.uu.se
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Rusyn, Ivan
AU - Beland, Frederick A.
T1 - Epigenetic Aspects of Genotoxic and Non-Genotoxic Hepatocarcinogenesis: Studies in Rodents.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/01//
VL - 49
IS - 1
M3 - Article
SP - 9
EP - 15
SN - 08936692
AB - The article focuses on the study of epigenetic alterations during rodent hepatocarcinogenesis. Evidence shows that the development of hepatocellular carcinoma (HCC) is linked with genetic alterations and profound epigenetic changes. The prominent etiological factors associated with HCC includes chronic viral hepatitis B and C infections, metabolic liver diseases, and exposure to environmental chemicals and alcohol. According to the study, global hypomethylation of DNA is one of the most common molecular alterations in cancer cells.
KW - DISEASES
KW - Carcinogenesis
KW - Diseases -- Causes & theories of causation
KW - Liver -- Cancer
KW - Rodents
KW - Liver metastasis
KW - Cancer cells
KW - Cellular pathology
KW - Viral hepatitis
KW - Genetic research
KW - epigenetics
KW - genotoxic carcinogens
KW - hepatocarcinogenesis
KW - non-genotoxic carcinogens
KW - rodents
N1 - Accession Number: 31267406; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov; Rusyn, Ivan 2; Beland, Frederick A. 1; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; 2: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina; Issue Info: Jan2008, Vol. 49 Issue 1, p9; Thesaurus Term: DISEASES; Thesaurus Term: Carcinogenesis; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Liver -- Cancer; Subject Term: Rodents; Subject Term: Liver metastasis; Subject Term: Cancer cells; Subject Term: Cellular pathology; Subject Term: Viral hepatitis; Subject Term: Genetic research; Author-Supplied Keyword: epigenetics; Author-Supplied Keyword: genotoxic carcinogens; Author-Supplied Keyword: hepatocarcinogenesis; Author-Supplied Keyword: non-genotoxic carcinogens; Author-Supplied Keyword: rodents; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 7p; Illustrations: 1 Color Photograph, 6 Black and White Photographs, 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1002/em.20342
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ju-Hyeong Park
AU - Cox-Ganser, Jean M.
AU - Kreiss, Kathleen
AU - White, Sandra K.
AU - Rao, Carol Y.
T1 - Hydrophilic Fungi and Ergosterol Associated with Respiratory Illness in a Water-Damaged Building.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/01//
VL - 116
IS - 1
M3 - Article
SP - 45
EP - 50
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Damp building-related respiratory illnesses are an important public health issue. OBJECTIVE: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with postoccupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. METHODS: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity ≥ 0.9), and ergosterol with the health outcomes using logistic regression models. RESULTS: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR) = 1.37-1.72], hydrophilic fungi (IQR-OR = 1.45-2.19), and ergosterol (IQR-OR = 1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR = 2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR = 1.54-1.55). CONCLUSIONS: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment. Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Indoor air pollution
KW - Molds (Fungi)
KW - Asthma
KW - Dampness in buildings
KW - Biomass
KW - Endotoxins
KW - Public health
KW - Respiratory allergy
KW - Ergosterol
KW - Regression analysis
KW - asthma
KW - dampness
KW - endotoxin
KW - ergosterol
KW - exposure
KW - hydrophilic fungi
KW - office building
KW - respiratory symptoms
KW - water damage
N1 - Accession Number: 28693734; Ju-Hyeong Park 1; Email Address: gzp8@cdc.gov; Cox-Ganser, Jean M. 1; Kreiss, Kathleen 1; White, Sandra K. 1; Rao, Carol Y. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Issue Info: Jan2008, Vol. 116 Issue 1, p45; Thesaurus Term: Indoor air pollution; Thesaurus Term: Molds (Fungi); Thesaurus Term: Asthma; Thesaurus Term: Dampness in buildings; Thesaurus Term: Biomass; Thesaurus Term: Endotoxins; Thesaurus Term: Public health; Subject Term: Respiratory allergy; Subject Term: Ergosterol; Subject Term: Regression analysis; Author-Supplied Keyword: asthma; Author-Supplied Keyword: dampness; Author-Supplied Keyword: endotoxin; Author-Supplied Keyword: ergosterol; Author-Supplied Keyword: exposure; Author-Supplied Keyword: hydrophilic fungi; Author-Supplied Keyword: office building; Author-Supplied Keyword: respiratory symptoms; Author-Supplied Keyword: water damage; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105900489
T1 - Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged building.
AU - Park J
AU - Cox-Ganser JM
AU - Kreiss K
AU - White SK
AU - Rao CY
Y1 - 2008/01//
N1 - Accession Number: 105900489. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 0330411.
KW - Air Pollutants -- Analysis
KW - Air Pollution, Indoor -- Analysis
KW - Asthma -- Microbiology
KW - Fungi
KW - Occupational Exposure -- Analysis
KW - Phytosterols -- Analysis
KW - Allergens -- Analysis
KW - Asthma -- Epidemiology
KW - Case Control Studies
KW - Colony Count, Microbial
KW - Dust -- Analysis
KW - Environmental Monitoring
KW - Female
KW - Male
KW - Middle Age
KW - Occupational Exposure -- Adverse Effects
KW - Water
KW - Human
SP - 45
EP - 50
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 116
IS - 1
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - BACKGROUND: Damp building-related respiratory illnesses are an important public health issue. OBJECTIVE: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with post-occupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. METHODS: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity > or = 0.9), and ergosterol with the health outcomes using logistic regression models. RESULTS: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR) = 1.37-1.72], hydrophilic fungi (IQR-OR = 1.45-2.19), and ergosterol (IQR-OR = 1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR = 2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR = 1.54-1.55). CONCLUSIONS: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment. Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments.
SN - 0091-6765
AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505 USA; gzp8@cdc.gov
U2 - PMID: 18197298.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900489&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McKernan, Lauralynn T.
AU - Ruder, Avima M.
AU - Petersen, Martin R.
AU - Hein, Misty J.
AU - Forrester, Christy L.
AU - Sanderson, Wayne T.
AU - Ashley, David L.
AU - Butler, Mary A.
T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry.
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
Y1 - 2008/01//
VL - 7
M3 - Article
SP - 1
EP - 10
PB - BioMed Central
SN - 1476069X
AB - Background: The purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects. Methods: Eighteen women from four dry cleaning facilities in southwestern Ohio were monitored in a pilot study of workers with PCE exposure. Personal breathing zone samples were collected from each employee on two consecutive work days. Biological monitoring included a single measurement of PCE in blood and multiple measurements of pre- and post-shift PCE in exhaled breath and trichloroacetic acid (TCA) in urine. Results: Post-shift PCE in exhaled breath gradually increased throughout the work week. Statistically significant correlations were observed among the exposure indices. Decreases in PCE in exhaled breath and TCA in urine were observed after two days without exposure to PCE. A mixed-effects model identified statistically significant associations between PCE in exhaled breath and airborne PCE time weighted average (TWA) after adjusting for a random participant effect and fixed effects of time and body mass index. Conclusion: Although comprehensive, our sampling strategy was challenging to implement due to fluctuating work schedules and the number (pre- and post-shift on three consecutive days) and multiplicity (air, blood, exhaled breath, and urine) of samples collected. PCE in blood is the preferred biological index to monitor exposures, but may make recruitment difficult. PCE TWA sampling is an appropriate surrogate, although more field intensive. Repeated measures of exposure and mixed-effects modeling may be required for future studies due to high within-subject variability. Workers should be monitored over a long enough period of time to allow the use of a lag term. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOLOGICAL exposure indices (Industrial toxicology)
KW - TETRACHLOROETHYLENE
KW - DRY cleaning industry
KW - HAZARDOUS substance exposure
KW - OCCUPATIONAL hazards
KW - OHIO
N1 - Accession Number: 35703122; McKernan, Lauralynn T. 1; Email Address: LTaylor@cdc.gov Ruder, Avima M. 1; Email Address: ARuder@cdc.gov Petersen, Martin R. 1; Email Address: MPetersen@cdc.gov Hein, Misty J. 1; Email Address: MHein@cdc.gov Forrester, Christy L. 1; Email Address: CForrester@cdc.gov Sanderson, Wayne T. 2; Email Address: wayne-sanderson@uiowa.edu Ashley, David L. 3; Email Address: DAshley@cdc.gov Butler, Mary A. 1; Email Address: MButler@cdc.gov; Affiliation: 1: Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA 2: University of Iowa Department of Occupational & Environmental Health, 100 Oakdale Campus, Iowa City, Iowa 52242, USA 3: CDC National Center for Environmental Health, 4770 Buford Highway, F-47, Atlanta, GA 30341-3724, USA; Source Info: 2008, Vol. 7, Special section p1; Subject Term: BIOLOGICAL exposure indices (Industrial toxicology); Subject Term: TETRACHLOROETHYLENE; Subject Term: DRY cleaning industry; Subject Term: HAZARDOUS substance exposure; Subject Term: OCCUPATIONAL hazards; Subject Term: OHIO; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1186/1476-069X-7-12
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35703122&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105596864
T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry.
AU - McKernan LT
AU - Ruder AM
AU - Petersen MR
AU - Hein MJ
AU - Forrester CL
AU - Sanderson WT
AU - Ashley DL
AU - Butler MA
Y1 - 2008/01//
N1 - Accession Number: 105596864. Language: English. Entry Date: 20100326. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 101147645.
KW - Hydrocarbons, Chlorinated -- Analysis
KW - Industry
KW - Occupational Exposure -- Analysis
KW - Adult
KW - Aged
KW - Body Mass Index
KW - Breath Tests
KW - Environmental Monitoring -- Methods
KW - Female
KW - Hydrocarbons, Chlorinated -- Blood
KW - Hydrocarbons, Chlorinated -- Urine
KW - Middle Age
KW - Pilot Studies
KW - Regression
KW - Solvents -- Analysis
KW - Human
SP - 12
EP - 12
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
JA - ENVIRON HEALTH
VL - 7
PB - BioMed Central
SN - 1476-069X
AD - Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA. LTaylor@cdc.gov
U2 - PMID: 18412959.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105596864&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105654693
T1 - Estimating infectious diseases incidence: validity of capture-recapture analysis and truncated models for incomplete count data.
AU - Van Hest NAH
AU - Grant AD
AU - Smit F
AU - Story A
AU - Richardus JH
Y1 - 2008/01//
N1 - Accession Number: 105654693. Language: English. Entry Date: 20080926. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Data Collection
KW - Linear Regression
KW - Population
KW - England
KW - Incidence
KW - Netherlands
KW - Reproducibility of Results
KW - Tuberculosis, Pulmonary -- Epidemiology
KW - Human
SP - 14
EP - 22
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 136
IS - 1
PB - Cambridge University Press
AB - Capture-recapture analysis has been used to evaluate infectious disease surveillance. Violation of the underlying assumptions can jeopardize the validity of the capture-recapture estimates and a tool is needed for cross-validation. We re-examined 19 datasets of log-linear model capture-recapture studies on infectious disease incidence using three truncated models for incomplete count data as alternative population estimators. The truncated models yield comparable estimates to independent log-linear capture-recapture models and to parsimonious log-linear models when the number of patients is limited, or the ratio between patients registered once and twice is between 0.5 and 1.5. Compared to saturated log-linear models the truncated models produce considerably lower and often more plausible estimates. We conclude that for estimating infectious disease incidence independent and parsimonious three-source log-linear capture-recapture models are preferable but truncated models can be used as a heuristic tool to identify possible failure in log-linear models, especially when saturated log-linear models are selected.
SN - 0950-2688
AD - Tuberculosis Control Physician/Epidemiologist, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam Area, PO Box 70032, 3000 LP Rotterdam, The Netherlands; vanhestr@ggd.rotterdam.nl
U2 - PMID: 17352840.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105654693&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
AU - Mutter, Ryan L.
AU - Rosko, Michael D.
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD
AD - Widener U
A2 - Blank, Jos L. T.
A2 - Valdmanis, Vivian G.
T1 - The Impact of Ownership on the Cost-Efficiency of U.S. Hospitals
T2 - Evaluating Hospital Policy and Performance: Contributions from Hospital Policy and Productivity Research
PB - Advances in Health Economics and Health Services Research, vol. 18. Amsterdam and Boston: Elsevier, JAI Press
Y1 - 2008///
SP - 113
EP - 138
N1 - Accession Number: 1056026; Reviewed Book ISBN: 978-0-7623-1453-9; Keywords: Cost; Hospital; Hospitals; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Collective Volume Article; Update Code: 200908
KW - Production; Cost; Capital; Capital, Total Factor, and Multifactor Productivity; Capacity D24
KW - Analysis of Health Care Markets I11
KW - Comparison of Public and Private Enterprises and Nonprofit Institutions; Privatization; Contracting Out L33
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1056026&site=ehost-live&scope=site
DP - EBSCOhost
DB - ecn
ER -
TY - NEWS
AU - Havert, Michael B.
T1 - A regulatory perspective on the development of gene therapy for Parkinson's disease
JO - Experimental Neurology
JF - Experimental Neurology
Y1 - 2008/01//
VL - 209
IS - 1
M3 - Editorial
SP - 48
EP - 50
SN - 00144886
N1 - Accession Number: 28125881; Havert, Michael B. 1; Email Address: mike.havert@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Center for Biologics Evaluation and Review, Office of Cellular, Tissue, and Gene Therapies, Division of Cellular and Gene Therapies, 1401 Rockville Pike, HFM-720, Rockville, MD 20852, USA; Source Info: Jan2008, Vol. 209 Issue 1, p48; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.expneurol.2007.08.010
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-07187-002
AN - 2008-07187-002
AU - Williams-Washington, Kristin N.
AU - Melon, Joanna
AU - Blau, Gary M.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
ED - Gullotta, Thomas P., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Childhood growth and development within a family context.
T2 - Family influences on childhood behavior and development: Evidence-based prevention and treatment approaches.
Y1 - 2008///
SP - 21
EP - 38
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-96532-3
N1 - Accession Number: 2008-07187-002. Partial author list: First Author & Affiliation: Williams-Washington, Kristin N.; Argosy University, Washington, DC, US. Release Date: 20080721. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-415-96532-3, Hardcover. Language: English. Major Descriptor: Childhood Development; Family Relations; Family; Protective Factors; Risk Factors. Minor Descriptor: Biology; Environment; Genetics; Parenting Style; Roles; Socialization; Systems. Classification: Developmental Psychology (2800); Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 18.
AB - Provides an overview of risk and protective factors with those contextual and family factors that are integral in child development. From fertilization through childhood and adolescence, a child's growth and development are influenced by a complex ever changing bio-psycho-social environmental set of factors. Within this world, children begin to identify themselves and to integrate external information with their internal definition of the world to establish an identity. As children move from reliance on their parents to autonomous beings capable of making their own decisions, familial support, genetic factors, good socialization skills and a healthy, enriched environment are key elements for a child achieving positive child developmental outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - childhood development
KW - family context
KW - risk factors
KW - protective factors
KW - biology
KW - genetics
KW - environmental factors
KW - parenting styles
KW - family member roles & rules
KW - socialization
KW - family system
KW - 2008
KW - Childhood Development
KW - Family Relations
KW - Family
KW - Protective Factors
KW - Risk Factors
KW - Biology
KW - Environment
KW - Genetics
KW - Parenting Style
KW - Roles
KW - Socialization
KW - Systems
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07187-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-07187-003
AN - 2008-07187-003
AU - Osher, Trina W.
AU - Osher, David
AU - Blau, Gary M.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
ED - Gullotta, Thomas P., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Families matter.
T2 - Family influences on childhood behavior and development: Evidence-based prevention and treatment approaches.
Y1 - 2008///
SP - 39
EP - 61
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-96532-3
N1 - Accession Number: 2008-07187-003. Partial author list: First Author & Affiliation: Osher, Trina W.; Huff Osher Consulting, Inc., US. Release Date: 20080721. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-415-96532-3, Hardcover. Language: English. Major Descriptor: Family; Health Care Delivery; Mental Health Services; Health Care Policy. Minor Descriptor: Evidence Based Practice; History. Classification: Health & Mental Health Services (3370); Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23.
AB - Being a parent and raising a child with an emotional, behavioral or mental health challenge is a full time job without pay, vacations or nights or weekends off. Families are the backbone of our society, and no matter the problem, and no matter the level of stress, families do matter in the lives of children. This chapter reviews the history of the family movement in the United States, provides evidence for the practice of family-driven care, demonstrates mental health practices that embrace family support, describes ways families can be included in policy and practice decisions and offers resources for practitioners and families to use to implement this approach to service delivery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family movement
KW - family-driven care
KW - mental health service delivery
KW - evidence based practice
KW - federal policy
KW - history
KW - children
KW - adolescents
KW - family support
KW - 2008
KW - Family
KW - Health Care Delivery
KW - Mental Health Services
KW - Health Care Policy
KW - Evidence Based Practice
KW - History
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07187-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-07187-005
AN - 2008-07187-005
AU - Keys, Susan G.
AU - Leaf, Philip J.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
ED - Gullotta, Thomas P., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Public health principles and approaches to systems interventions to support children's emotional and behavioral health.
T2 - Family influences on childhood behavior and development: Evidence-based prevention and treatment approaches.
Y1 - 2008///
SP - 97
EP - 116
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-96532-3
N1 - Accession Number: 2008-07187-005. Partial author list: First Author & Affiliation: Keys, Susan G.; Prevention Initiatives and Priority Programs Development Branch, Division of Prevention, Traumatic Stress and Special Programs, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, MD, US. Release Date: 20080721. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-415-96532-3, Hardcover. Language: English. Major Descriptor: Childhood Development; Health Promotion; Intervention; Mental Health; Public Health. Minor Descriptor: Communities; Family; Prevention; Protective Factors; Risk Factors; Schools; Systems. Classification: Health & Mental Health Treatment & Prevention (3300); Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 20.
AB - This chapter proposes that communities, including mental health professionals, consumer advocates and policy makers, expand their focus and activities beyond a concern with a treatment-based system of care to encompass a broader perspective that focuses on positive development, mental health promotion and prevention and addresses individual, family and community promotive, risk and protective factors. This cannot be accomplished by focusing on children alone but requires adopting a public health or population-based approach that engages multiple systems--individual, family, school, neighborhood and community--and recognizes that these systems exist within specific cultural, historical, sociopolitical and economic settings. Such actions and solutions need to include a full continuum of complementary interventions--from mental health promotion and youth development to prevention and treatment to maximize and support emotional and behavioral health and positive development for all children and youth. The chapter identifies the activities of a public health approach and the multiple system interventions that need to occur if communities are to achieve a comprehensive, population-based system of care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public health
KW - systems interventions
KW - children
KW - emotional & behavioral health
KW - mental health promotion & prevention
KW - families
KW - communities
KW - positive development
KW - risk & protective factors
KW - individuals
KW - 2008
KW - Childhood Development
KW - Health Promotion
KW - Intervention
KW - Mental Health
KW - Public Health
KW - Communities
KW - Family
KW - Prevention
KW - Protective Factors
KW - Risk Factors
KW - Schools
KW - Systems
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07187-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-07187-009
AN - 2008-07187-009
AU - Fisher, Sylvia Kay
AU - Easterly, Susan
AU - Lazear, Katherine J.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
ED - Gullotta, Thomas P., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Lesbian, gay, bisexual and transgender families and their children.
T2 - Family influences on childhood behavior and development: Evidence-based prevention and treatment approaches.
Y1 - 2008///
SP - 187
EP - 208
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-96532-3
N1 - Accession Number: 2008-07187-009. Partial author list: First Author & Affiliation: Fisher, Sylvia Kay; Child, Adolescent and Family Branch, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Welfare, US. Release Date: 20080721. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-415-96532-3, Hardcover. Language: English. Major Descriptor: Bisexuality; Family; Homosexual Parents; Transsexualism. Minor Descriptor: Childhood Development; Evidence Based Practice; Family Intervention; Prevention; Resilience (Psychological); Risk Factors; Social Discrimination; Stigma; Treatment. Classification: Marriage & Family (2950); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - Families headed by at least one gay, lesbian, bisexual or transgendered (LGBT) parent have become increasingly common in today's society. This chapter provides an overview of some of the issues associated with LGBT-headed families, including those that may lead to seeking professional services and support such as promising practices in clinical interventions. Providing services for LGBT families requires that the helping person educate himself or herself about the needs and concerns that LGBT families are likely to present during the clinical hour. Because much of the limited literature available about LGBT families is focused on gays and lesbians rather than on bisexual and transgendered persons, many of the studies and associated statements included in this chapter address families headed by gays and lesbians rather than by bisexual or transgendered persons. Factors influencing risk and resiliency are examined. Evidence-based treatment interventions for LGTB families are described. The prevention of stigma and discrimination in LGTB families is discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gay
KW - lesbian
KW - bisexual
KW - transgendered
KW - parents
KW - children
KW - LGBT families
KW - risks
KW - resiliency
KW - treatment interventions
KW - evidence-based practices
KW - prevention
KW - stigma
KW - discrimination
KW - 2008
KW - Bisexuality
KW - Family
KW - Homosexual Parents
KW - Transsexualism
KW - Childhood Development
KW - Evidence Based Practice
KW - Family Intervention
KW - Prevention
KW - Resilience (Psychological)
KW - Risk Factors
KW - Social Discrimination
KW - Stigma
KW - Treatment
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07187-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lee, I.P.
AU - Kang, B.H.
AU - Roh, J.K.
AU - Kim, J.R.
T1 - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 87
EP - 95
SN - 02786915
AB - Abstract: The Brazilian mushroom Agaricus blazei Murill has antimutagenic, antioxidant, immunostimulatory and antitumorigenic activities, and is increasingly consumed as a health food worldwide. We undertook the present study to evaluate the chronic toxicity and oncogenicity of A. blazei Murill in F344 rats. To establish a no-observed-adverse-effect level (NOAEL), four treatment groups of 100 rats each (50 males and 50 females) were fed a powder diet containing lyophilized A. blazei aqueous extract at 0, 6250, 12,500, and 25,000ppm for up to 2 years. During this period, there was no remarkable change in mean body weight, body weight gain, hematologic or serum chemistry parameters, or absolute or relative organ weights in control or treatment groups. Mortality in male treatment groups (26%, 16%, and 30%), however, was significantly lower than in controls (48%). Histopathological studies showed no increased incidence of tumors in any treatment group, and total tumor incidence across all groups was comparable to historical data. In conclusion, an A. blazei Murill lyophilized powder diet even at 25,000ppm (1176mg/kgb.w./day for male rats and 1518mg/kgb.w./day for female rats) resulted in no remarkable carcinogenic effects in F344 rats over a 2-year period. Therefore, the dietary NOAEL is 25,000ppm. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSHROOMS
KW - AGARICUS
KW - ANTIMUTAGENS
KW - ANTIOXIDANTS
KW - IMMUNOLOGICAL adjuvants
KW - FOOD
KW - ABMK
KW - Agaricus blazei Murill
KW - Dietary supplement
KW - Mushroom
N1 - Accession Number: 27943506; Lee, I.P. 1; Email Address: iplee0823@aol.com Kang, B.H. 2 Roh, J.K. 2 Kim, J.R. 3; Affiliation: 1: Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Republic of Korea 2: Division of Pathology, Korea Institute of Toxicology, 101 Jang Dong, Dae Duk Danji, Daejon, Republic of Korea 3: Office of National Statistics of Korea, 33 Ka Jong Dong, Dong, Dae Duk Danji, Daejon, Republic of Korea; Source Info: Jan2008, Vol. 46 Issue 1, p87; Subject Term: MUSHROOMS; Subject Term: AGARICUS; Subject Term: ANTIMUTAGENS; Subject Term: ANTIOXIDANTS; Subject Term: IMMUNOLOGICAL adjuvants; Subject Term: FOOD; Author-Supplied Keyword: ABMK; Author-Supplied Keyword: Agaricus blazei Murill; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: Mushroom; NAICS/Industry Codes: 111411 Mushroom Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2007.07.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27943506&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whittaker, Paul
AU - Clarke, Jane J.
AU - San, Richard H.C.
AU - Betz, Joseph M.
AU - Seifried, Harold E.
AU - de Jager, Lowri S.
AU - Dunkel, Virginia C.
T1 - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 168
EP - 174
SN - 02786915
AB - Abstract: Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both d-kawain and dl-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KAVA plant
KW - KAVA (Beverage)
KW - PEPPER (Spice)
KW - SIZE reduction of materials
KW - MASTICATION
KW - TOXICITY testing
KW - 7,12-dimethylbenzanthracene ( DMBA )
KW - dimethyl sulfoxide ( DMSO )
KW - Kava
KW - Kava pyrones
KW - Kavalactones
KW - liquid chromatography–mass spectrometry ( LC–MS )
KW - Mouse lymphoma
KW - Mutagenicity
KW - National Cancer Institute ( NCI )
KW - National Institutes of Health ( NIH )
KW - Piper methysticum
KW - single ion monitoring ( SIM )
KW - thymidine kinase ( TK )
KW - trifluorothymidine ( TFT )
KW - US Food and Drug Administration ( FDA )
N1 - Accession Number: 27943516; Whittaker, Paul 1; Email Address: paul.whittaker@fda.hhs.gov Clarke, Jane J. 2 San, Richard H.C. 2 Betz, Joseph M. 3 Seifried, Harold E. 4 de Jager, Lowri S. 1 Dunkel, Virginia C. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States 2: BioReliance, Rockville, MD, United States 3: Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, United States 4: National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; Source Info: Jan2008, Vol. 46 Issue 1, p168; Subject Term: KAVA plant; Subject Term: KAVA (Beverage); Subject Term: PEPPER (Spice); Subject Term: SIZE reduction of materials; Subject Term: MASTICATION; Subject Term: TOXICITY testing; Author-Supplied Keyword: 7,12-dimethylbenzanthracene ( DMBA ); Author-Supplied Keyword: dimethyl sulfoxide ( DMSO ); Author-Supplied Keyword: Kava; Author-Supplied Keyword: Kava pyrones; Author-Supplied Keyword: Kavalactones; Author-Supplied Keyword: liquid chromatography–mass spectrometry ( LC–MS ); Author-Supplied Keyword: Mouse lymphoma; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: National Cancer Institute ( NCI ); Author-Supplied Keyword: National Institutes of Health ( NIH ); Author-Supplied Keyword: Piper methysticum; Author-Supplied Keyword: single ion monitoring ( SIM ); Author-Supplied Keyword: thymidine kinase ( TK ); Author-Supplied Keyword: trifluorothymidine ( TFT ); Author-Supplied Keyword: US Food and Drug Administration ( FDA ); NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fct.2007.07.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ju, Young H.
AU - Doerge, Daniel R.
AU - Helferich, William G.
T1 - A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 310
EP - 320
SN - 02786915
AB - Abstract: Avlimil, a dietary supplement advertised to ameliorate female sexual dysfunction, is a mixture of eleven herbal components, and some herbal constituents of Avlimil (including black cohosh, licorice, red raspberry, red clover and kudzu) contain phenolic compounds, which are suggested to have estrogenic, anti-estrogenic, or androgenic potential for relieving menopausal symptoms. We hypothesize that Avlimil could modulate the growth of estrogen receptor positive human breast cancer (MCF-7) cells in vitro and in vivo. A dimethylsulfoxide (DMSO) extract of Avlimil (0.001–100μg Avlimil powder equivalents/mL media) was tested for its estrogenic and anti-estrogenic effects on the growth of MCF-7 cells in vitro. We observed that the DMSO extract of Avlimil at low concentrations (0.1–50μg/mL media) dose-dependently increased MCF-7 cell proliferation in vitro, and Avlimil DMSO extract at 100μg/mL inhibited the growth of MCF-7 cells in vitro. Avlimil and some constituents (black cohosh and licorice roots) of Avlimil were fractionated by using sequential solvent extraction (hexane, ethyl acetate, and methanol) and the activities of the fractions were monitored by effects on the growth of MCF-7 cells. Depending on dosage (0.1–100μg/mL media) both stimulatory and inhibitory effects of the extracts on the growth of MCF-7 cells were observed. The effect of dietary Avlimil at dosages approximating human intake was evaluated using ovariectomized mice implanted with MCF-7 cells. Animals were fed diets containing 500ppm or 1000ppm Avlimil for 16 weeks. Dietary Avlimil at 500ppm stimulated MCF-7 tumors, but Avlimil at 1000ppm had no apparent effect on the growth of MCF-7 tumors. The observation of stimulated tumor growth in the absence of uterine wet weight gains suggest that estrogenic/anti-estrogenic effects of Avlimil we observed may be dosage- and target tissue-specific and that Avlimil may not be safe for women with estrogen-dependent breast cancer. The different biological effects of fractionated Avlimil components and the different concentration dependencies warrant further compound identification and dose-response studies, especially at recommended intake levels that could have estrogenic effects in women. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUAL dysfunction
KW - DIETARY supplements
KW - CANCER in women
KW - BREAST cancer
KW - OVARIECTOMY
KW - ESTROGEN receptors
KW - NUDE mouse
KW - (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) ( MTT )
KW - 17β-estradiol ( E2 )
KW - American Institute of Nutrition 93 growth semi-purified diet ( AIN93G )
KW - Avlimil
KW - black cohosh ( BC )
KW - Black cohosh root
KW - bovine calf serum ( BCS )
KW - Breast cancer
KW - charcoal-dextran stripped BCS ( CD-BCS )
KW - dimethylsuloxide ( DMSO )
KW - estrogen receptor ( ER )
KW - hormone replacement therapy ( HRT )
KW - Isoflavones
KW - Licorice root
KW - licorice root ( LC )
KW - MCF-7
KW - Michigan Cancer Foundation-7 ( MCF-7 )
KW - minimal essential media ( MEM )
KW - reverse transcription polymerase chain reaction ( qRT-PCR )
KW - standard error ( SE )
N1 - Accession Number: 27943532; Ju, Young H. 1 Doerge, Daniel R. 2 Helferich, William G. 1; Email Address: helferic@uiuc.edu; Affiliation: 1: Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, United States 2: National Center for Toxicological Research, Jefferson, AR 72079, United States; Source Info: Jan2008, Vol. 46 Issue 1, p310; Subject Term: SEXUAL dysfunction; Subject Term: DIETARY supplements; Subject Term: CANCER in women; Subject Term: BREAST cancer; Subject Term: OVARIECTOMY; Subject Term: ESTROGEN receptors; Subject Term: NUDE mouse; Author-Supplied Keyword: (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) ( MTT ); Author-Supplied Keyword: 17β-estradiol ( E2 ); Author-Supplied Keyword: American Institute of Nutrition 93 growth semi-purified diet ( AIN93G ); Author-Supplied Keyword: Avlimil; Author-Supplied Keyword: black cohosh ( BC ); Author-Supplied Keyword: Black cohosh root; Author-Supplied Keyword: bovine calf serum ( BCS ); Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: charcoal-dextran stripped BCS ( CD-BCS ); Author-Supplied Keyword: dimethylsuloxide ( DMSO ); Author-Supplied Keyword: estrogen receptor ( ER ); Author-Supplied Keyword: hormone replacement therapy ( HRT ); Author-Supplied Keyword: Isoflavones; Author-Supplied Keyword: Licorice root; Author-Supplied Keyword: licorice root ( LC ); Author-Supplied Keyword: MCF-7; Author-Supplied Keyword: Michigan Cancer Foundation-7 ( MCF-7 ); Author-Supplied Keyword: minimal essential media ( MEM ); Author-Supplied Keyword: reverse transcription polymerase chain reaction ( qRT-PCR ); Author-Supplied Keyword: standard error ( SE ); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.fct.2007.08.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsai, Pei
AU - Cao, Guan-Liang
AU - Merkel, Tod J.
AU - Rosen, Gerald M.
T1 - Spin labelling of Bacillus anthracis endospores: A model for in vivo tracking by EPR imaging.
JO - Free Radical Research
JF - Free Radical Research
Y1 - 2008/01//
VL - 42
IS - 1
M3 - Article
SP - 49
EP - 56
PB - Taylor & Francis Ltd
SN - 10715762
AB - Anthrax is caused by the gram-negative bacterium, Bacillus anthracis. Infection by this microbe results from delivery of the endospore form of the bacillus through direct contact, either topical or inhalation. With regard to the latter route of administration, it is proposed that endospores of B. anthracis enter the lungs and are phagocytized by host alveolar macrophages. Thereafter, it is unclear as to how endospores travel to distal loci and what tissues are the targets. Herein, this study describes the spin labelling of endospores through two different approaches with various aminoxyls. Indeed, after exposure to RAW 264.7 cells, these aminoxyl-containing endospores were phagocytized, as demonstrated by EPR spectroscopy of the infected macrophage, thus providing a potential tool for EPR imaging in animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Free Radical Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS anthracis
KW - SPECTRUM analysis
KW - MEDICAL research
KW - ANTHRAX
KW - BACTERIAL diseases
KW - acetoxymethoxycarbonyl-containing aminoxyls
KW - Bacillus anthracis
KW - electron paramagnetic resonance spectroscopy
KW - maleimide-containing aminoxyls
N1 - Accession Number: 31192821; Tsai, Pei 1,2,3 Cao, Guan-Liang 1,2,3 Merkel, Tod J. 4 Rosen, Gerald M. 1,2,3; Email Address: grosen@umaryland.edu; Affiliation: 1: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA 2: Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA 3: Center for EPR Imaging In Vivo Physiology, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA 4: Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike Bethesda, MD 20892, USA; Source Info: Jan2008, Vol. 42 Issue 1, p49; Subject Term: BACILLUS anthracis; Subject Term: SPECTRUM analysis; Subject Term: MEDICAL research; Subject Term: ANTHRAX; Subject Term: BACTERIAL diseases; Author-Supplied Keyword: acetoxymethoxycarbonyl-containing aminoxyls; Author-Supplied Keyword: Bacillus anthracis; Author-Supplied Keyword: electron paramagnetic resonance spectroscopy; Author-Supplied Keyword: maleimide-containing aminoxyls; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 4 Diagrams, 5 Graphs; Document Type: Article
L3 - 10.1080/10715760701787701
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Salazar, Edith L.
AU - Calzada, Leobardo
T1 - Hormone catalysis: Role of protecting and modifying reagents of sulfhydryl groups on estrogen receptor in breast cancer.
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
Y1 - 2008/01//
VL - 24
IS - 1
M3 - Article
SP - 30
EP - 32
PB - Taylor & Francis Ltd
SN - 09513590
AB - We have studied the modulation and differential sensitivity of the estrogen receptor (ER) in breast cancer in the presence of protecting or modifying agents of disulfide bonds and sulfhydryl groups present in the ER steroid-binding domain. Protecting agents such as mercaptoethanol and dithiotreitol increased the [3H]estradiol binding to ER by 25% and 50%, respectively. Modifying agents such as p-chloromercuribenzensulfonate decreased the [3H]estradiol binding by 70% and this was nearly completely abolished by N-ethylmaleimide (94%). These data indicate that disulfide bonds and sulfhydryl groups in the steroid-binding domain are intimately involved in the maintenance of a receptor structure necessary for estradiol binding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - STEROID-binding proteins
KW - ESTRADIOL
KW - ESTROGEN receptors
KW - ENDOCRINE disruptors
KW - THERAPEUTIC use
KW - Breast cancer
KW - disufide bonds
KW - estrogen receptor
KW - sulfhydryl groups
N1 - Accession Number: 28605256; Salazar, Edith L. 1; Email Address: dra_edith_salazar@yahoo.com.mx Calzada, Leobardo 2; Email Address: edith_lsalazar@hotmail.com; Affiliation: 1: Medical Research Unit in Endocrine Disease, Medical Research Coordination, Social Security Mexican Institute (IMSS), Mexico City, Mexico 2: Health Center (T-III) Dr. Manuel Escontria, Sanitary Jurisdiction Alvaro Obregon, Public Health Service of Distrito Federal, Mexico City, Mexico; Source Info: Jan2008, Vol. 24 Issue 1, p30; Subject Term: BREAST cancer; Subject Term: STEROID-binding proteins; Subject Term: ESTRADIOL; Subject Term: ESTROGEN receptors; Subject Term: ENDOCRINE disruptors; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: disufide bonds; Author-Supplied Keyword: estrogen receptor; Author-Supplied Keyword: sulfhydryl groups; Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1080/09513590701673692
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2007-16458-002
AN - 2007-16458-002
AU - Voursney, David de
AU - Mannix, Danyelle
AU - Brounstein, Paul J.
AU - Blau, Gary M.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
ED - Gullotta, Thomas P., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Childhood growth and development.
T2 - Handbook of childhood behavioral issues: Evidence-based approaches to prevention and treatment.
Y1 - 2008///
SP - 19
EP - 39
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 0-415-95461-4
SN - 978-0-415-95461-7
N1 - Accession Number: 2007-16458-002. Partial author list: First Author & Affiliation: Voursney, David de; Educational Services, Inc, US. Release Date: 20080204. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 0-415-95461-4, Hardcover; 978-0-415-95461-7, Hardcover. Language: English. Major Descriptor: Childhood Development; Psychosocial Factors; Sociocultural Factors. Classification: Developmental Psychology (2800). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - Genetic and biological factors, familial, social, and environmental influences all play important and varying roles across the life span. These factors have interactive effects on development, impacting growth at the same time as they influence each other. The idea that children's development is formed as they pass through interrelated systems is not a new one. By looking across individual biological, family, community, and broader social systems we are learning a great deal about the precursors and determinants of observed outcomes. The adoption of an ecological model that incorporates the physical and social sciences together will allow for a more complete understanding of the various factors that shape development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial factors
KW - childhood development
KW - 2008
KW - Childhood Development
KW - Psychosocial Factors
KW - Sociocultural Factors
KW - 2008
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DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-02530-013
AN - 2008-02530-013
AU - Foulds, Jonathan
AU - Delnevo, Cristine
AU - Ziedonis, Douglas M.
AU - Steinberg, Michael B.
ED - Brick, John
ED - Brick, John, (Ed)
T1 - Health effects of tobacco, nicotine, and exposure to tobacco smoke pollution.
T2 - Handbook of the medical consequences of alcohol and drug abuse, 2nd ed.
T3 - The Haworth Press series in neuropharmacology
Y1 - 2008///
SP - 423
EP - 459
CY - New York, NY
PB - The Haworth Press/Taylor and Francis Group
SN - 978-0-7890-3574-5
SN - 978-0-7890-3573-8
N1 - Accession Number: 2008-02530-013. Partial author list: First Author & Affiliation: Foulds, Jonathan; Tobacco Dependence Program, School of Public Health, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, US. Release Date: 20080414. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-7890-3574-5, Paperback; 978-0-7890-3573-8, Hardcover. Language: English. Grant Information: Foulds, Jonathan. Major Descriptor: Death and Dying; Nicotine; Side Effects (Drug); Smokeless Tobacco; Tobacco Smoking. Minor Descriptor: Disorders; Passive Smoking; Smoking Cessation. Classification: Drug & Alcohol Usage (Legal) (2990); Psychological & Physical Disorders (3200). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 37.
AB - This chapter reviews the medical consequences of tobacco and nicotine use. This chapter focuses on the effects of chronic cigarette smoking (the most prevalent type of nicotine use) on specific diseases and overall mortality. It also discusses the effects of different types of tobacco, evidence for dose-response effects, the effects of reduction and cessation of cigarette use, the effects of passive exposure to tobacco smoke, and the psychiatric effects of tobacco use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tobacco use
KW - nicotine use
KW - smoking
KW - nicotine effects
KW - tobacco
KW - disease
KW - mortality
KW - dose response effects
KW - reduction
KW - cessation
KW - passive exposure
KW - psychiatric effects
KW - 2008
KW - Death and Dying
KW - Nicotine
KW - Side Effects (Drug)
KW - Smokeless Tobacco
KW - Tobacco Smoking
KW - Disorders
KW - Passive Smoking
KW - Smoking Cessation
KW - 2008
U1 - Sponsor: New Jersey Department of Health and Senior Services, US. Recipients: Foulds, Jonathan; Delnevo, Cristine; Ziedonis, Douglas M.; Steinberg, Michael B.
U1 - Sponsor: New Jersey's Comprehensive Tobacco Control Program, US. Recipients: No recipient indicated
U1 - Sponsor: Cancer Institute of New Jersey. Recipients: Foulds, Jonathan; Steinberg, Michael B.
U1 - Sponsor: Robert Wood Johnson Foundation. Recipients: Foulds, Jonathan; Delnevo, Cristine; Steinberg, Michael B.
U1 - Sponsor: National Institute on Drug Abuse, US. Recipients: Foulds, Jonathan; Ziedonis, Douglas M.
U1 - Sponsor: National Cancer Institute, US. Recipients: Delnevo, Cristine
U1 - Sponsor: National Institute of Mental Health, US. Recipients: Delnevo, Cristine
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: Ziedonis, Douglas M.
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Banthin, Jessica S.
AU - Cunningham, Peter
AU - Bernard, Didem M.
T1 - Financial Burden Of Health Care, 2001-2004.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/01//Jan/Feb2008
VL - 27
IS - 1
M3 - Article
SP - 188
EP - 195
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Analysis of data from the Medical Expenditure Panel Survey (MEPS) shows that rising out-of-pocket expenses and stagnant incomes increased health spending's financial burden for families in 2001-2004, especially for the privately insured. High financial burdens among those with nongroup coverage increased by more than one-third. Despite evidence of increased cost sharing in private insurance plans, our analysis does not show that privately insured people paid a higher share of their total health care bill in 2004 compared to 2001. Financial burdens have increased to the point at which private insurance is no longer able to provide financial protection for an increasing number of families. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MEDICAL economics
KW - HEALTH insurance reimbursement
KW - GOVERNMENT insurance
KW - MEDICAL care -- Law & legislation
KW - MEDICAL laws & legislation
KW - MEDICAL policy
KW - UNITED States
N1 - Accession Number: 28321551; Banthin, Jessica S. 1 Cunningham, Peter 2; Email Address: pcunningham@hschange.org Bernard, Didem M. 1; Affiliation: 1: Division of Modeling and Simulation Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and quality (AHRQ), in Rockville, Maryland. 2: Center for Studying Health System Change in Washington, D.C.; Source Info: Jan/Feb2008, Vol. 27 Issue 1, p188; Subject Term: MEDICAL care costs; Subject Term: MEDICAL economics; Subject Term: HEALTH insurance reimbursement; Subject Term: GOVERNMENT insurance; Subject Term: MEDICAL care -- Law & legislation; Subject Term: MEDICAL laws & legislation; Subject Term: MEDICAL policy; Subject Term: UNITED States; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1377/hlthaff.27.1.188
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28321551&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105894090
T1 - Pathways to coverage: the changing roles of public and private sources.
AU - Vistnes JP
AU - Schone BS
Y1 - 2008/01//Jan/Feb2008
N1 - Accession Number: 105894090. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Insurance Coverage -- Trends
KW - Insurance, Health -- Utilization
KW - Public Assistance -- Utilization
KW - Adult
KW - Child
KW - Health Services Accessibility -- Economics
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Middle Age
KW - Private Sector
KW - Public Sector
KW - United States
SP - 44
EP - 57
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Using data from the Medical Expenditure Panel Surveys for 1997 and 2005, spanning the eight-year period after enactment of the State Children's Health Insurance Program (SCHIP), we examine whether the composition of insurance coverage has changed for working families. Public coverage has played an increasingly important role for working families with children. For families without access to job-based insurance, roughly two-thirds of single-parent and over half of two-parent families with children had at least one family member covered by public insurance in 2005. Among families with access to job-based insurance, nearly half of minority single-parent families had at least one family member with public coverage.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA. Jessica.Vistnes@ahrq.hhs.gov
U2 - PMID: 18180479.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105894104
T1 - Financial burden of health care, 2001-2004.
AU - Banthin JS
AU - Cunningham P
AU - Bernard DM
Y1 - 2008/01//Jan/Feb2008
N1 - Accession Number: 105894104. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Economic Aspects of Illness
KW - Economics -- Trends
KW - Health Care Costs -- Trends
KW - Insurance, Health -- Economics
KW - Demography
KW - Economics -- Statistics and Numerical Data
KW - Family
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Services Needs and Demand -- Economics
KW - Insurance, Health -- Trends
KW - Social Class
KW - United States
SP - 188
EP - 195
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 1
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Analysis of data from the Medical Expenditure Panel Survey (MEPS) shows that rising out-of-pocket expenses and stagnant incomes increased health spending's financial burden for families in 2001-2004, especially for the privately insured. High financial burdens among those with nongroup coverage increased by more than one-third. Despite evidence of increased cost sharing in private insurance plans, our analysis does not show that privately insured people paid a higher share of their total health care bill in 2004 compared to 2001. Financial burdens have increased to the point at which private insurance is no longer able to provide financial protection for an increasing number of families.
SN - 0278-2715
AD - Division of Modeling and Simulation Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 18180494.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fleishman, John A.
AU - Moore, Richard D.
AU - Conviser, Richard
AU - Lawrence, Perrin B.
AU - Korthuis, P. Todd
AU - Gebo, Kelly A.
T1 - Associations between Outpatient and Inpatient Service Use among Persons with HIV Infection: A Positive or Negative Relationship?
JO - Health Services Research
JF - Health Services Research
Y1 - 2008/01//
VL - 43
IS - 1p1
M3 - Article
SP - 76
EP - 95
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To examine the prospective association between frequency of outpatient visits and subsequent inpatient admissions. Data Sources. Medical record data on 13,942 patients with HIV infection seen in 10 HIV speciality care sites across the United States. Study Design. This observational study followed a cohort of HIV-infected patients who were in care in the first half of 2001. Numbers of inpatient admissions and outpatient visits were calculated for each patient for each 3-month period, from 2001 through 2004. Analysis. Negative binomial and logistic regression analyses using random-effects models examined the effects of inpatient admissions and outpatient visits in the previous period on inpatient and outpatient service utilization, controlling for background characteristics and HIV disease stage. Results. For 3-month periods, between 5 and 9 percent of patients had an inpatient admission. The linear association between number of outpatient visits and any inpatient admission in the subsequent period was positive (adjusted odds ratio=1.05; 95 percent confidence interval [CI]=1.04, 1.06). However, patients with zero prior outpatient visits had significantly greater admission rates than those with one prior visit. Hospitalization rates were also higher among those with a prior hospitalization and those with more advanced HIV disease. Conclusions. These results suggest a J-shaped relationship between outpatient use and inpatient use among persons with HIV disease. Those in worse health have greater utilization of both inpatient and outpatient care. However, having no outpatient visits may also increase the likelihood of subsequent hospitalization. Although outpatient care cannot be justified as a cost-saving mechanism, maintaining regular clinical monitoring of patients is important. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections
KW - OUTPATIENT medical care
KW - MEDICAL records
KW - HIV-positive persons
KW - REGRESSION analysis
KW - CONFIDENCE intervals
KW - UNITED States
KW - HIV infection
KW - inpatient service use
KW - outpatient service use
N1 - Accession Number: 28397460; Fleishman, John A. 1 Moore, Richard D. 2 Conviser, Richard 3,4 Lawrence, Perrin B. 2 Korthuis, P. Todd 5 Gebo, Kelly A. 2; Affiliation: 1: Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 3: HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, MD 4: 2780 Lorraine Ave., Missoula, MT 5: Department of Medicine, Oregon Health and Science University, Portland, OR; Source Info: Jan2008, Vol. 43 Issue 1p1, p76; Subject Term: HIV infections; Subject Term: OUTPATIENT medical care; Subject Term: MEDICAL records; Subject Term: HIV-positive persons; Subject Term: REGRESSION analysis; Subject Term: CONFIDENCE intervals; Subject Term: UNITED States; Author-Supplied Keyword: HIV infection; Author-Supplied Keyword: inpatient service use; Author-Supplied Keyword: outpatient service use; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; Number of Pages: 20p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2007.00750.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fukaya, Kiyoshi
AU - Uchida, Mitsuya
T1 - Protection against Impact with the Ground Using Wearable Airbags.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 59
EP - 65
SN - 00198366
AB - The article discusses the importance of airbag in protection against falls from heights. The author claims that the airbag is an effective protection from incidental falls from heights, falls caused slipping or tripping, and falls from wheelchair overturns are commonplace phenomena, associated with serious injuries from impact with the ground. Furthermore, a wearable airbag device is a countermeasure applicable to the mentioned types of incident.
KW - Research
KW - Safety
KW - Accident prevention
KW - Falls (Accidents)
KW - Accidents
KW - Fall
KW - Protective devices
KW - Slip
KW - Trip
KW - Wearable airbag
KW - Wheelchair overturn
N1 - Accession Number: 32532148; Fukaya, Kiyoshi 1; Uchida, Mitsuya 2; Affiliations: 1: National Institute of Occupational Safety and Health, Umezono 1–4–6, Kiyose-shi, Tokyo 204-0024, Japan; 2: Prop Corporation, Tenjincho 8, Shinjyuku-ku, Tokyo 162-8766, Japan; Issue Info: 2008, Vol. 46 Issue 1, p59; Thesaurus Term: Research; Thesaurus Term: Safety; Subject Term: Accident prevention; Subject Term: Falls (Accidents); Subject Term: Accidents; Author-Supplied Keyword: Fall; Author-Supplied Keyword: Protective devices; Author-Supplied Keyword: Slip; Author-Supplied Keyword: Trip; Author-Supplied Keyword: Wearable airbag; Author-Supplied Keyword: Wheelchair overturn; Number of Pages: 7p; Illustrations: 8 Black and White Photographs, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kim, In-Ju
AU - Nagata, Hisao
T1 - Research on Slip Resistance Measurements—A New Challenge.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 66
EP - 76
SN - 00198366
AB - The article reports on the slips, trips and falls as one of the most common causes of injuries and fatalities in the general community and industry. It says that the control of the incidents mentioned involves a complex array of factors including the characteristics of each individual's footwear and gait dynamics, walking and working surfaces, and environmental conditions. To address the problem, the concept of slip resistance and the shoe-floor friction measurement was extensively analysed.
KW - Research
KW - Falls (Accidents)
KW - Accidents
KW - Footwear
KW - Friction
KW - COF
KW - Floors
KW - Shoes
KW - Slip Resistance
KW - Tribology and Wear
N1 - Accession Number: 32532149; Kim, In-Ju 1; Nagata, Hisao 2; Affiliations: 1: University of Exeter, Heavitree Road, Exeter, Devon, EX1 2LU, United Kingdom; 2: National Institute of Occupational Safety and Health, 1–4–6 Umezono, Kiyose, Tokyo 204-0024, Japan; Issue Info: 2008, Vol. 46 Issue 1, p66; Thesaurus Term: Research; Subject Term: Falls (Accidents); Subject Term: Accidents; Subject Term: Footwear; Subject Term: Friction; Author-Supplied Keyword: COF; Author-Supplied Keyword: Floors; Author-Supplied Keyword: Shoes; Author-Supplied Keyword: Slip Resistance; Author-Supplied Keyword: Tribology and Wear; NAICS/Industry Codes: 414120 Footwear merchant wholesalers; NAICS/Industry Codes: 424340 Footwear Merchant Wholesalers; Number of Pages: 11p; Illustrations: 5 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Smith, Derek R.
T1 - Tobacco Smoking by Occupation in Australia and the United States: A Review of National Surveys Conducted between 1970 and 2005.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 77
EP - 89
SN - 00198366
AB - The article discusses the impact of tobacco smoking on the industry in the U.S. and Australia. It says that smoking is a major cause of death worldwide, smokers have greater absences from work, more sick days per year, health care costs up to 50 percent higher compared to non smokers. In addition, employers bear a major burden when their staff smoke because it decreased productivity due to smoking breaks and even fire insurance losses following the improper disposal of cigarettes.
KW - Smoking
KW - Tobacco
KW - Industries
KW - Employees
KW - Australia
KW - United States
KW - Epidemiology
KW - Occupation
KW - Survey
N1 - Accession Number: 32532150; Smith, Derek R. 1,2; Affiliations: 1: WorkCover New South Wales Research Center of Excellence, University of Newcastle, Ourimbah 2258, Australia; 2: International Centre for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 6–21–1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; Issue Info: 2008, Vol. 46 Issue 1, p77; Thesaurus Term: Smoking; Subject Term: Tobacco; Subject Term: Industries; Subject Term: Employees; Subject: Australia; Subject: United States; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Occupation; Author-Supplied Keyword: Survey; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 111910 Tobacco Farming; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McKinney, Walter
AU - Frazer, Dave
T1 - Computer-Controlled Ozone Inhalation Exposure System.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2008/01//
VL - 20
IS - 1
M3 - Article
SP - 43
EP - 48
SN - 08958378
AB - Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisonous gases -- Toxicology
KW - Nitrogen oxides
KW - Carbon monoxide
KW - Atmospheric nitrogen oxides
KW - Radioactive aerosols
KW - Aerosol therapy
N1 - Accession Number: 28768194; McKinney, Walter 1; Email Address: wdm9@cdc.gov; Frazer, Dave 1; Affiliations: 1: Centers for Disease Control/National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Jan2008, Vol. 20 Issue 1, p43; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Nitrogen oxides; Thesaurus Term: Carbon monoxide; Thesaurus Term: Atmospheric nitrogen oxides; Thesaurus Term: Radioactive aerosols; Subject Term: Aerosol therapy; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 3 Diagrams, 2 Graphs; Document Type: Article
L3 - 10.1080/08958370701758544
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stettler, Lloyd E.
AU - Sharpnack, Douglas D.
AU - Krieg, Edward F.
T1 - Chronic Inhalation of Short Asbestos: Lung Fiber Burdens and Histopathology for Monkeys Maintained for 11.5 Years after Exposure.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2008/01//
VL - 20
IS - 1
M3 - Article
SP - 63
EP - 73
SN - 08958378
AB - In an earlier report, Platek et al. (1985) presented the results of an 18-month inhalation exposure of rats and monkeys to short chrysotile asbestos. The mean chamber exposure level was 1.0 mg/m3with an average of 0.79 fibers/ml > 5 μ m in length. Gross and histopathological examination of exposed and control rats indicated no treatment-related lesions. Asbestos bodies adjacent to the terminal bronchioles, but no fibrosis, were found in lung biopsy tissue taken from the exposed monkeys at 10 months post-exposure. Fifteen monkeys (9 exposed and 6 controls) from this study were maintained for 11.5 years following exposure. Lung fiber burdens were determined by transmission electron microscopy. The mean lung burden (± standard deviation) for 59 samples from exposed monkeys was 63 ± 30× 106 fibers/g dry lung (range, 18-139 × 106). The geometric mean fiber length was 3.5 μ m with 35% of the fibers being > 5 μ m in length. These data indicate some chrysotile fibers are durable in vivo for a significant period of time. Lungs were examined grossly and microscopically. No lesions attributable to the inhalation exposure were noted. Asbestos bodies were seen in the lungs of treated monkeys, primarily in the interstitium near bronchioles or small pulmonary blood vessels (which also may have been near to bronchioles just out of the plane of section). [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisonous gases -- Toxicology
KW - Asbestos -- Toxicology
KW - Respiratory therapy
KW - Pathological histology
KW - Respiratory organs
KW - Clinical pathology
N1 - Accession Number: 28768202; Stettler, Lloyd E. 1; Sharpnack, Douglas D. 1; Email Address: dsharpnack@vetpathservicesinc.com; Krieg, Edward F. 1; Affiliations: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Jan2008, Vol. 20 Issue 1, p63; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Asbestos -- Toxicology; Subject Term: Respiratory therapy; Subject Term: Pathological histology; Subject Term: Respiratory organs; Subject Term: Clinical pathology; Number of Pages: 11p; Illustrations: 5 Diagrams, 4 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/08958370701665566
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ayres, Jon G.
AU - Borm, Paul
AU - Cassee, Flemming R.
AU - Castranova, Vincent
AU - Donaldson, Ken
AU - Ghio, Andy
AU - Harrison, Roy M.
AU - Hider, Robert
AU - Kelly, Frank
AU - Kooter, Ingeborg M.
AU - Marano, Francelyne
AU - Maynard, Robert L.
AU - Mudway, Ian
AU - Nel, Andre
AU - Sioutas, Constantinos
AU - Smith, Steve
AU - Baeza-Squiban, Armelle
AU - Cho, Art
AU - Duggan, Sean
AU - Froines, John
T1 - Evaluating the Toxicity of Airborne Particulate Matter and Nanoparticles by Measuring Oxidative Stress Potential - A Workshop Report and Consensus Statement.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2008/01//
VL - 20
IS - 1
M3 - Article
SP - 75
EP - 99
SN - 08958378
AB - Background: There is a strong need for laboratory in vitro test systems for the toxicity of airborne particulate matter and nanoparticles. The measurement of oxidative stress potential offers a promising way forward. Objectives:Aworkshop was convened involving leading workers from the field in order to review the available test methods and to generate a Consensus Statement. Discussions: Workshop participants summarised their own research activities as well as discussion the relative merits of different test methods. Conclusions: In vitro test methods have an important role to play in the screening of toxicity in airborne particulate matter and nanoparticles. In vitro cell challenges were preferable to in vitro acellular systems but both have a potential major role to play and offer large cost advantages relative to human or animal inhalation studies and animal in vivo installation experiments. There remains a need to compare tests one with another on standardised samples and also to establish a correlation with the results of population-based epidemiology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Radioactive aerosols
KW - Oxidation-reduction reaction
KW - Lung diseases
KW - Nanoparticles
KW - Oxidative stress
N1 - Accession Number: 28768201; Ayres, Jon G. 1; Borm, Paul 2; Cassee, Flemming R. 3; Castranova, Vincent 4; Donaldson, Ken 5; Ghio, Andy 6; Harrison, Roy M. 7; Email Address: r.m.harrison@bham.ac.uk; Hider, Robert 8; Kelly, Frank 9; Kooter, Ingeborg M. 10; Marano, Francelyne 11; Maynard, Robert L. 12; Mudway, Ian 13; Nel, Andre 14; Sioutas, Constantinos 15; Smith, Steve 16; Baeza-Squiban, Armelle 11; Cho, Art 14; Duggan, Sean 17; Froines, John 14; Affiliations: 1: Liberty Safe Work Research Centre, Foresterhill Road, Aberdeen, Scotland, United Kingdom; 2: Centre of Expertise in Life Sciences (CEL), Zuyd University, Netherlands; 3: Centre for Environmental Health Research, National Institute for Public Health and the Environment Bilthoven, The Netherlands; 4: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA; 5: Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK; 6: Clinical Research Branch, Human Studies Facility, U.S. Environmental Protection Agency, Chapel Hill, North Carolina, USA; 7: Division of Environmental Health & Risk Management, School of Geography, Earth and Environmental Sciences, Edgbaston, Birmingham, United Kingdom; 8: School of Biomedical and Health Sciences, King's College, London, United Kingdom; 9: Pharmaceutical Sciences, Franklin-Wilkins Building, London, United Kingdom; 10: Department of Inhalation Toxicology, Centre for Environmental Health Research (MGO), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 11: Laboratoire de Cytophysiologie et Toxicologie Cellulaire, Paris, France; 12: Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chemical Hazards and Poisons Division(Headquarters), Chilton DIDCOT, Oxfordshire, United Kingdom; 13: School of Biomedical & Health Sciences, Guy's Campus, London, United Kingdom; 14: Department of Medicine at UCLA, Los Angeles, California, USA; 15: Department of Civil and Environmental Engineering, Los Angeles, California, USA; 16: Department of Life Sciences, King's College London, Strand, London, United Kingdom; 17: School of Biomedical and Health Sciences, Guy's Campus, London, United Kingdom; Issue Info: Jan2008, Vol. 20 Issue 1, p75; Thesaurus Term: Air pollution; Thesaurus Term: Radioactive aerosols; Thesaurus Term: Oxidation-reduction reaction; Subject Term: Lung diseases; Subject Term: Nanoparticles; Subject Term: Oxidative stress; Number of Pages: 25p; Illustrations: 1 Black and White Photograph, 3 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/08958370701665517
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
AU - Pezzin, Liliana E.
AU - Pollak, Robert A.
AU - Schone, Barbara S.
AD - Medical College of WI
AD - Washington U in St Louis
AD - Agency for Healthcare Research and Quality
A2 - Booth, Alan
A2 - Crouter, Ann C.
A2 - Bianchi, Suzanne M.
A2 - Seltzer, Judith A.
T1 - Family Bargaining and Long-Term Care of the Disabled Elderly
T2 - Intergenerational Caregiving
PB - Washington, D.C.: Urban Institute Press
Y1 - 2008///
SP - 257
EP - 275
N1 - Accession Number: 1067906; Reviewed Book ISBN: 978-0-87766-747-6; ; Publication Type: Collective Volume Article; Update Code: 200911
KW - Relation of Economics to Other Disciplines A12
KW - Household Behavior: General D10
KW - Fertility; Family Planning; Child Care; Children; Youth J13
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DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Khan, Saeed A.
AU - Sung, Kidon
AU - Layton, Sherryll
AU - Nawaz, Mohamed S.
T1 - Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2008/01//
VL - 31
IS - 1
M3 - Article
SP - 27
EP - 36
SN - 09248579
AB - Abstract: A clinical strain of Enterococcus faecium ATCC 51559 exhibits heteroresistance, i.e. a high level of resistance to vancomycin (minimum inhibitory concentration (MIC)>256μg/mL) by broth dilution but sensitivity to vancomycin by Etest (MIC=1.8μg/mL). Three variants of this strain, EF1, EF2 and EF3, exhibit high levels of resistance to vancomycin both by broth dilution and Etest assays. The four strains were used to study heteroresistance by pulsed-field gel electrophoresis (PFGE), polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequence analysis of a partial region of the van operon. Minor differences between SalI and SmaI restriction profiles of the variants and the parental strain were observed by PFGE analysis. PCR analysis confirmed the presence of the vancomycin resistance marker vanA (0.73kb) and a larger than expected amplicon (8.2kb vs. 6.7kb) of the van operon in all the strains. The 8.2kb van operon was cloned for EcoRI RFLP and sequence analysis. All of the clones exhibited distinctly different RFLP profiles when grown in the presence of kanamycin or vancomycin+kanamycin. The presence of these antibiotics during overnight growth of EF1 on plates also resulted in altered SalI PFGE profiles. Sequence analysis of the van operon clones revealed a 1.5kb IS1251-like insertion element between the vanS and vanH genes in all the strains. Several novel point mutations in the vanR, vanS, vanH, vanA, vanX and vanY genes were also discovered. Some of these mutations were present in the parental strain only and included base substitutions T→C, A→G, T→A and T→C at nucleotide positions 4202, 4597, 4763 and 6207 of Tn1546, resulting in amino acid replacements I76→T and K208→E of vanR, S19→T of vanS and L64→P of vanH genes, respectively. We believe that these are responsible for the observed heteroresistance. The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin-resistant enterococci strains as a result of continuous exposure to antibiotics. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Vancomycin
KW - Gel electrophoresis
KW - Electrophoresis
KW - Insertion element
KW - Polymerase chain reaction
KW - Pulsed-field gel electrophoresis
KW - Restriction fragment length polymorphism
KW - Vancomycin-resistant enterococci
N1 - Accession Number: 27949067; Khan, Saeed A.; Email Address: saeed.khan@fda.hhs.gov; Sung, Kidon 1; Layton, Sherryll 1; Nawaz, Mohamed S. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Jan2008, Vol. 31 Issue 1, p27; Thesaurus Term: Antibacterial agents; Subject Term: Vancomycin; Subject Term: Gel electrophoresis; Subject Term: Electrophoresis; Author-Supplied Keyword: Insertion element; Author-Supplied Keyword: Polymerase chain reaction; Author-Supplied Keyword: Pulsed-field gel electrophoresis; Author-Supplied Keyword: Restriction fragment length polymorphism; Author-Supplied Keyword: Vancomycin-resistant enterococci; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2007.08.007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Johnson-Taylor, Wendy L.
AU - Fisher, Rachel A.
AU - Hubbard, Van S.
AU - Starke-Reed, Pamela
AU - Eggers, Paul S.
T1 - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES.
JO - International Journal of Behavioral Nutrition & Physical Activity
JF - International Journal of Behavioral Nutrition & Physical Activity
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 6
SN - 14795868
AB - Objectives: This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods: The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m²) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results: Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion: The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004 has been accompanied with fewer overweight people perceiving themselves as overweight. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Behavioral Nutrition & Physical Activity is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BODY weight
KW - OVERWEIGHT persons
KW - OBESITY
KW - DISEASE prevalence
KW - BODY mass index
N1 - Accession Number: 35703428; Johnson-Taylor, Wendy L. 1; Email Address: wj50v@nih.gov Fisher, Rachel A. 1; Email Address: fisherrachel@mail.nih.gov Hubbard, Van S. 1; Email Address: hubbardv@mail.nih.gov Starke-Reed, Pamela 1; Email Address: starkep@mail.nih.gov Eggers, Paul S. 2; Email Address: eggersp@mail.nih.gov; Affiliation: 1: US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, MD, USA 2: US Department of Health and Human Services, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA; Source Info: 2008, Vol. 5, Special section p1; Subject Term: BODY weight; Subject Term: OVERWEIGHT persons; Subject Term: OBESITY; Subject Term: DISEASE prevalence; Subject Term: BODY mass index; Number of Pages: 6p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1479-5868-5-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lu, Ming-Lun
AU - James, Tamara
AU - Lowe, Brian
AU - Barrero, Marisol
AU - Kong, Yong-Ku
T1 - An investigation of hand forces and postures for using selected mechanical pipettes
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/01//
VL - 38
IS - 1
M3 - Article
SP - 18
EP - 29
SN - 01698141
AB - Abstract: The present study evaluated thumb, hand forces, wrist, forearm and shoulder postures used for pipetting with three selected mechanical pipettes. Twelve pipette users in a large university health system participated in pipetting simulation in their own laboratories to investigate the effects of pipette type, body posture (standing/seated), sample volume (200/1000μL) and pipetting task on the physical risk factors. The thumb and hand forces were measured with 19 Flexiforce™ sensors. Wrist and forearm postures were measured with an electrogoniometer and a torsiometer, respectively. Humeral elevation as shoulder postural stress was assessed by observations from videos recorded during pipetting simulation. The study results showed several advantages of using the non-axial pipette over the traditional axial ones. The non-axial pipette was associated with approximately 2–6 times less thumb and hand force than the traditional axial pipettes. In addition, there were approximately 20–30% reductions in ulnar deviation and 30–70% reductions in humeral elevation to operate the non-axial pipette for most of the pipetting actions. One disadvantage of using the non-axial pipette appears to be increased forearm pronation by approximately 100–150% for the entire pipetting cycle, as compared to the axial pipettes. The results of the study may provide useful information regarding design of pipettes for reducing physical risk factors associated with pipetting. Relevance to industry: This paper demonstrated hand forces and postures for common pipetting tasks with selected mechanical pipettes. The hand force and postural data for using axial and non-axial pipettes may provide key information for hand injury prevention due to pipetting in the industry. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Buildings
KW - Universities & colleges
KW - Detectors
KW - Engineering instruments
KW - Musculoskeletal disorders
KW - Non-axial design
KW - Pipette
N1 - Accession Number: 28150066; Lu, Ming-Lun 1; Email Address: mlu@cdc.gov; James, Tamara 2; Lowe, Brian 1; Barrero, Marisol 3; Kong, Yong-Ku 4; Affiliations: 1: National Institute for Occupational Safety and Health, Taft Laboratories, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226, USA; 2: Duke Occupational and Environmental Safety Office, Box 3834, Duke University, Durham, NC 27710, USA; 3: Mitsui Sumitomo Insurance Group, 312 Elm Street, Suite 1250, Cincinnati, OH 45202, USA; 4: Department of Systems Management Engineering, Sungkyunkwan University, Suwon, South Korea; Issue Info: Jan2008, Vol. 38 Issue 1, p18; Thesaurus Term: Buildings; Subject Term: Universities & colleges; Subject Term: Detectors; Subject Term: Engineering instruments; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Non-axial design; Author-Supplied Keyword: Pipette; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.ergon.2007.08.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Meeuwissen, Jolanda A. C.
AU - van der Feltz-Cornelis, Christina M.
AU - van Marwijk, Harm W. J.
AU - Rijnders, Paul B. M.
AU - Donker, Marianne C. H.
T1 - A stepped care programme for depression management: an uncontrolled pre-post study in primary and secondary care in The Netherlands.
JO - International Journal of Integrated Care (IJIC)
JF - International Journal of Integrated Care (IJIC)
Y1 - 2008/01//Jan-Mar2008
VL - 8
M3 - Article
SP - 1
EP - 11
SN - 15684156
AB - Introduction: Stepped care strategies are potentially effective to organise integrated care but unknown is whether they function well in practice. This paper evaluates the implementation of a stepped care programme for depression in primary care and secondary care. Theory and methods: We developed a stepped care algorithm for diagnostics and treatment of depression, supported by a liaison-consultation function. In a 21/2 year study with pre-post design in a pilot region, adherence to the protocol was assessed by interviewing 28 caregivers of 235 patients with mild, moderate, or severe major depression. Consultation and referral patterns between primary and secondary care were analysed. Results: Adherence of general practitioners and consultant caregivers to the stepped care protocol proved to be 96%. The percentage of patients referred for depression to secondary care decreased significantly from 26% to 21% (p=0.0180). In the post-period more patients received treatment in primary care and requests for consultation became more concordant with the stepped care protocol. Conclusions: Implementation of a stepped care programme is feasible in a primary and secondary care setting and is associated with less referrals. Discussion: Further research on all subsequent treatment steps in a standardised stepped care protocol is needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Integrated Care (IJIC) is the property of Ubiquity Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression -- Treatment
KW - PRIMARY care (Medicine)
KW - MEDICAL care
KW - DEPRESSED persons
KW - MEDICAL referral
KW - MEDICAL protocols
KW - NETHERLANDS
KW - depression management
KW - integrated care
KW - liaison-consultation
KW - stepped care
KW - transmural care
KW - treatment algorithm
N1 - Accession Number: 33205049; Meeuwissen, Jolanda A. C. 1; Email Address: jmeeuwissen@trimbos.nl van der Feltz-Cornelis, Christina M. 2 van Marwijk, Harm W. J. 3 Rijnders, Paul B. M. 4 Donker, Marianne C. H. 5; Affiliation: 1: Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands 2: Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, and VU University Medical Centre Institute of Extramural Research, Amsterdam, The Netherlands 3: University Medical Centre, EMGO-Institute, Department of General Practice, Amsterdam, The Netherlands 4: Emergis, Centre for Mental Health Care, Goes, The Netherlands 5: Professor of Public Health Policy, Erasmus Medical Centre Rotterdam, Department of Public Health, and General Director of the Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands; Source Info: Jan-Mar2008, Vol. 8, p1; Subject Term: MENTAL depression -- Treatment; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL care; Subject Term: DEPRESSED persons; Subject Term: MEDICAL referral; Subject Term: MEDICAL protocols; Subject Term: NETHERLANDS; Author-Supplied Keyword: depression management; Author-Supplied Keyword: integrated care; Author-Supplied Keyword: liaison-consultation; Author-Supplied Keyword: stepped care; Author-Supplied Keyword: transmural care; Author-Supplied Keyword: treatment algorithm; Number of Pages: 11p; Illustrations: 2 Diagrams, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105904711
T1 - How useful are voluntary medication error reports? The case of warfarin-related medication errors.
AU - Zhan C
AU - Smith SR
AU - Keyes MA
AU - Hicks RW
AU - Cousins DD
AU - Clancy CM
Y1 - 2008/01//2008 Jan
N1 - Accession Number: 105904711. Language: English. Entry Date: 20080502. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 101238023.
KW - Medication Errors
KW - Voluntary Reporting
KW - Warfarin
KW - Aged
KW - Data Analysis, Statistical
KW - Documentation
KW - Exploratory Research
KW - Female
KW - Health Information Systems
KW - Inpatients
KW - Male
KW - Middle Age
KW - Outpatients
KW - Patient Safety
KW - Warfarin -- Administration and Dosage
KW - Human
SP - 36
EP - 45
JO - Joint Commission Journal on Quality & Patient Safety
JF - Joint Commission Journal on Quality & Patient Safety
JA - JOINT COMM J QUAL PATIENT SAF
VL - 34
IS - 1
CY - Oak Brook, Illinois
PB - Joint Commission Resources
AB - Background: A study was conducted to explore the value and limitations of voluntary medical error reports and to learn about common errors in warfarin use.Methods: Voluntary reports of 8,837 inpatient errors and 820 outpatient errors in warfarin use submitted by 445 hospitals and 192 outpatient facilities participating in MEDMARX® , a voluntary medication error reporting system, from 2002 to 2004, were gathered.Results: Overall, errors occurred most often during transcription/documentation (35%) and administration (30%) in hospitals, and during prescribing (31%) and dispensing (39%) in outpatient settings. Dosing errors were the most common type. In hospitals, more than 50% of reported errors were initiated by nurses, and 50% were intercepted by nurses, whereas in outpatient settings, about 50% of reported errors occurred in pharmacies and 50% were intercepted by pharmacists. About 17% of inpatient and 13% of outpatient warfarin errors resulted in changes in patient care, and 42% of inpatient and 62% of outpatient errors resulted in procedural changes. Cascade analysis and textual descriptions further located specific, correctible safety lapses.Discussion: Voluntary medical error reporting systems can, to some extent, provide meaningful and actionable information to guide patient safety improvement, but their usefulness is limited because of a lack of details, incomplete reporting, underreporting, and various reporting biases.
SN - 1553-7250
AD - Health Scientist Administrator, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Satchithanandam, Subramaniam
AU - Grundel, Erich
AU - Roach, John
AU - White, Kevin D.
AU - Mazzola, Eugene
AU - Ganzera, Markus
AU - Rader, Jeanne I.
T1 - Alkaloids and Saponins in Dietary Supplements of Blue Cohosh (Caulophyllum thalictroides).
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/01//Jan/Feb2008
VL - 91
IS - 1
M3 - Article
SP - 21
EP - 32
PB - AOAC International
SN - 10603271
AB - The article discusses a study which examined the concentration of alkaloids and saponins in dietary supplements of blue cohosh, Caulophyllum thalictroides (family Berberidaceae) using high-performance liquid chromatography. Photodiode array detector was used to monitor the alkaloids while an evaporative light-scattering detector was used to monitor saponins. Results showed that maximum daily intake of alkaloids and saponins varies with the form and doses recommended in product labeling.
KW - BERBERIDACEAE
KW - ALKALOIDS
KW - SAPONINS
KW - DIETARY supplements
KW - HIGH performance liquid chromatography
N1 - Accession Number: 30670575; Satchithanandam, Subramaniam 1 Grundel, Erich 1 Roach, John 1 White, Kevin D. 1 Mazzola, Eugene 1 Ganzera, Markus 2 Rader, Jeanne I. 1; Email Address: jeanne.rader@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD 20740 2: University of Innsbruck, Department of Pharmacognosy, Institute of Pharmacy, 6020 Innsbruck, Austria; Source Info: Jan/Feb2008, Vol. 91 Issue 1, p21; Subject Term: BERBERIDACEAE; Subject Term: ALKALOIDS; Subject Term: SAPONINS; Subject Term: DIETARY supplements; Subject Term: HIGH performance liquid chromatography; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 12p; Illustrations: 1 Diagram, 8 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hammack, Thomas S.
AU - Jacobson, Andrew P.
AU - Andrews, Wallace H.
T1 - The Effect of Preenrichment and Selective Enrichment Media on Recovery of Salmonella Typhi from the Tropical Fruit Mamey.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/01//Jan/Feb2008
VL - 91
IS - 1
M3 - Article
SP - 83
EP - 91
PB - AOAC International
SN - 10603271
AB - The article discusses a study which examines the sensitivity of the Bacteriological Analytical Manual (BAM) Salmonella culture method for the recovery of Salmonella typhi from the tropical fruit mamey. The effect of preenrichment and selective enrichment media on the recovery was examined. It appears that ferric ammonium citrate enhanced the growth of S. typhi.
KW - CULTURES (Biology)
KW - SALMONELLA typhi
KW - TROPICAL fruit
KW - CULTURE media (Biology)
KW - AMMONIUM compounds
N1 - Accession Number: 30670582; Hammack, Thomas S. 1; Email Address: thomas.hammack@fda.hhs.gov Jacobson, Andrew P. 1 Andrews, Wallace H. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Microbiology, College Park, MD 20740; Source Info: Jan/Feb2008, Vol. 91 Issue 1, p83; Subject Term: CULTURES (Biology); Subject Term: SALMONELLA typhi; Subject Term: TROPICAL fruit; Subject Term: CULTURE media (Biology); Subject Term: AMMONIUM compounds; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 111330 Non-citrus fruit and tree nut farming; Number of Pages: 9p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105906336
T1 - Depression in public community long-term care: implications for intervention development.
AU - Morrow-Howell N
AU - Proctor E
AU - Choi S
AU - Lawrence L
AU - Brooks A
AU - Hasche L
AU - Dore P
AU - Blinne W
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
AU - Choi, Sunha
AU - Lawrence, Lisa
AU - Brooks, Ashley
AU - Hasche, Leslie
AU - Dore, Peter
AU - Blinne, Wayne
Y1 - 2008/01//
N1 - Accession Number: 105906336. Language: English. Entry Date: 20080502. Revision Date: 20161115. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: T32 MH019960/MH/NIMH NIH HHS/United States. NLM UID: 9803531.
KW - Depression -- Epidemiology
KW - Housing for the Elderly
KW - Public Sector
KW - Aged
KW - Aged, 80 and Over
KW - Cross Sectional Studies
KW - Depression -- Diagnosis
KW - Depression -- Therapy
KW - Female
KW - Male
KW - Middle Age
KW - Midwestern United States
KW - Human
SP - 37
EP - 51
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
JA - J BEHAV HEALTH SERV RES
VL - 35
IS - 1
CY - ,
PB - Springer Science & Business Media B.V.
AB - The objective of this paper is to increase understanding of geriatric depression in the public community long-term care system to guide intervention development. Protocols included screening 1,170 new clients of a public community long-term care agency and interviewing all clients with major, dysthymia, or subthreshold depression (n = 299) and a randomly selected subset of nondepressed older adults (n = 315) at baseline, 6-month, and 1 year. Six percent had major depression, one-half of a percent had dysthymia only, and another 19% had subthreshold depression. Over the year observation period, 40% were persistently depressed; 32% were assessed as depressed only at the first observation; and the remainder was intermittently depressed. There were high levels of comorbid medical, functional, and psychosocial conditions. Mental health service use was low, and clients reported attitudinal and other barriers to depression treatment. Findings suggest the need for universal screening for depression with some strategies for triaging the most severely and persistently depressed for treatment. Although there will be challenges to the development of depression interventions, the public community long-term care system has high potential to assist vulnerable older adults receive help with depression.
SN - 1094-3412
AD - Center for Mental Health Services Research, Washington University, St. Louis, MO 63130, USA
AD - Center for Mental Health Services Research, Washington University, Campus Box 1196, St. Louis, MO, 63130, USA, morrow-howell@wustl.edu.
U2 - PMID: 18158624.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gannavaram, Sreenivas
AU - Vedvyas, Chetan
AU - Debrabant, Alain
T1 - Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites.
JO - Journal of Cell Science
JF - Journal of Cell Science
Y1 - 2008/01//1/1/2008
VL - 121
IS - 1
M3 - Article
SP - 10
EP - 10
SN - 00219533
AB - Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the protozoan cell death pathways and the effector molecules involved in such processes remain to be identified. In this report, we describe the pro-apoptotic function of endonuclease G in trypanosomatid parasites. Similar to metazoans, trypanosome endoG showed intrinsic nuclease activity, is localized in mitochondria and is released from this organelle when cell death is triggered. Overexpression of endoG strongly promoted apoptotic cell death under oxidant or differentiation-related stress in Leishmania and, conversely, loss of endoG expression conferred robust resistance to oxidant-induced cell death in T. brucei. These data demonstrate the conservation of the pro-apoptotic endonuclease activity of endoG in these evolutionarily ancient eukaryotic organisms. Furthermore, nuclear DNA degradation by endoG upon release from mitochondria might represent a caspase-independent cell death mechanism in trypanosomatid parasites as genes encoding caspase-like proteins have not been identified in their genomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Science is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEASES
KW - ENDONUCLEASES
KW - TRYPANOSOMATIDAE
KW - PROTEINS
KW - APOPTOSIS
KW - CELL death
KW - MITOCHONDRIA
KW - GENOMES
KW - Apoptotic Nucleases
KW - DNA fragmentation
KW - Endonuclease G
KW - Programmed cell death
KW - Trypanosomatid parasites
N1 - Accession Number: 28441766; Gannavaram, Sreenivas 1 Vedvyas, Chetan 1 Debrabant, Alain 1; Email Address: alain.debrabant@fda.hhs.gov; Affiliation: 1: Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda MD 20892, USA; Source Info: 1/1/2008, Vol. 121 Issue 1, p10; Subject Term: NUCLEASES; Subject Term: ENDONUCLEASES; Subject Term: TRYPANOSOMATIDAE; Subject Term: PROTEINS; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: MITOCHONDRIA; Subject Term: GENOMES; Author-Supplied Keyword: Apoptotic Nucleases; Author-Supplied Keyword: DNA fragmentation; Author-Supplied Keyword: Endonuclease G; Author-Supplied Keyword: Programmed cell death; Author-Supplied Keyword: Trypanosomatid parasites; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ronald L. Evans
AU - Paul H. Siitonen
T1 - Determination of Caffeine and Sympathomimetic Alkaloids in Weight Loss Supplements by High-Performance Liquid Chromatography.
JO - Journal of Chromatographic Science
JF - Journal of Chromatographic Science
Y1 - 2008/01//
VL - 46
IS - 1
M3 - Article
SP - 61
EP - 67
SN - 00219665
AB - Reversed-phase high-performance liquid chromatography utilizing photodiode array detection is used for the simultaneous determination of caffeine and nine alkaloids from Citrus aurantium (CA) and ephedra (EA) contained in dietary weight loss products. Since the Food and Drug Administration (FDA) ban of EA, manufacturers have substituted CA in their weight loss formulations, usually combined with high levels of caffeine. The alkaloids contained in CA have some physiological effects similar to those of the EA alkaloids and are, therefore, cause for concern. Caffeine has been shown to potentiate the toxicity of the EA alkaloids. Recently, a federal judge overturned the absolute ban and allowed marketing of low levels (< 10 mg/day) of total EA alkaloids. To support an absolute ban, the FDA is now compelled to perform dose-dependent toxicology studies to determine the toxic dose(s) of EA. The toxicity of the CA compounds is largely unknown, especially in combination with caffeine. The described method enables quantitation over a wide range of product formulations. Recoveries range from 91% to 100% from a variety of fortified plant matrices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Chromatographic Science is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAFFEINE
KW - ALKALOIDS
KW - DIETARY supplements
KW - APPETITE depressants
N1 - Accession Number: 28714045; Ronald L. Evans 1 Paul H. Siitonen 1; Affiliation: 1: National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Division of Biochemical Toxicology, Jefferson, AR 72079; Source Info: Jan2008, Vol. 46 Issue 1, p61; Subject Term: CAFFEINE; Subject Term: ALKALOIDS; Subject Term: DIETARY supplements; Subject Term: APPETITE depressants; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fu, Peter P.
AU - Xia, Qingsu
AU - Guo, Lei
AU - Yu, Hongtao
AU - Chan, Po-Chuen
T1 - Toxicity of Kava Kava.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2008/01//Jan-Mar2008
VL - 26
IS - 1
M3 - Article
SP - 89
EP - 112
SN - 10590501
AB - Kava is a traditional beverage of various Pacific Basin countries. Kava has been introduced into the mainstream U.S. market principally as an anti-anxiety preparation. The effects of the long-term consumption of kava have not been documented adequately. Preliminary studies suggest possible serious organ system effects. The potential carcinogenicity of kava and its principal constituents are unknown. As such, kava extract was nominated for the chronic tumorigenicity bioassay conducted by the National Toxicology Program (NTP). At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biological assay
KW - Carcinogenicity testing
KW - Kava (Beverage)
KW - Tranquilizing drugs
KW - Hepatotoxicology
KW - United States
KW - anti-anxiety herbal beverage
KW - hepatotoxicity
KW - Kava
KW - mechanism
KW - metabolism
KW - top-selling botanical
KW - National Toxicology Program (U.S.)
N1 - Accession Number: 31183635; Fu, Peter P. 1; Xia, Qingsu 1; Guo, Lei 1; Yu, Hongtao 2; Chan, Po-Chuen 3; Affiliations: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA; 2: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA; 3: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; Issue Info: Jan-Mar2008, Vol. 26 Issue 1, p89; Thesaurus Term: Biological assay; Thesaurus Term: Carcinogenicity testing; Subject Term: Kava (Beverage); Subject Term: Tranquilizing drugs; Subject Term: Hepatotoxicology; Subject: United States; Author-Supplied Keyword: anti-anxiety herbal beverage; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: Kava; Author-Supplied Keyword: mechanism; Author-Supplied Keyword: metabolism; Author-Supplied Keyword: top-selling botanical ; Company/Entity: National Toxicology Program (U.S.); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 24p; Illustrations: 6 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1080/10590500801907407
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31183635&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grant, Michael A.
T1 - Comparison of Escherichia coli O157:H7 Enrichment in Spiked Produce Samples.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/01//
VL - 71
IS - 1
M3 - Article
SP - 139
EP - 145
SN - 0362028X
AB - Two strains of Escherichia coli O157:H7 were spiked into six varieties of produce at approximately 0.5 CFU g-1. Samples were enriched by using the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) method and by using an experimental method incorporating acid shock. Target colonies were detectable on selective agars after 30 of 48 analyses with BAM enrichment and 48 of 48 analyses with acid enrichment. Real-time PCR screening of 24-h enrichment broths revealed the presence of the diagnostic stx1 or stx2 genes after 27 of 48 analyses with BAM enrichment and 42 of 48 analyses with acid enrichment. The efficiency of the enrichment varied with strain and type of produce spiked but overall was better with the experimental enrichment method. Modifications of both the acid enrichment and BAM enrichment methods also were tested. The acid method with a modified incubation temperature consistently yielded high rates of recovery (> 108 CFU ml-1), with no instances in which target cells could not be detected. Modification of the BAM procedure did not reproducibly improve enrichment efficiency. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Microbiology
KW - Acids
KW - Escherichia coli O157:H7
KW - Genes
KW - Cells
KW - United States
N1 - Accession Number: 28685749; Grant, Michael A. 1; Email Address: mike.grant@fda.hhs.gov; Affiliations: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Bothell, Washington 98021, USA; Issue Info: Jan2008, Vol. 71 Issue 1, p139; Thesaurus Term: Microbiology; Thesaurus Term: Acids; Subject Term: Escherichia coli O157:H7; Subject Term: Genes; Subject Term: Cells; Subject: United States; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 7p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yancy, Haile F.
AU - Zemlark, Tyler S.
AU - Mason, Jacquline A.
AU - Washington, Jewell D.
AU - Tenge, Bradley J.
AU - Nguyen, Ngoc-Lan T.
AU - Barnett, James D.
AU - Savary, Warren E.
AU - Hill, Walter E.
AU - Moore, Michelle M.
AU - Fry, Frederick S.
AU - Randolph, Spring C.
AU - Rogers, Patricia L.
AU - Hebert, Paul D. N.
T1 - Potential Use of DNA Barcodes in Regulatory Science: Applications of the Regulatory Fish Encyclopedia.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/01//
VL - 71
IS - 1
M3 - Article
SP - 210
EP - 217
SN - 0362028X
AB - The use of a DNA-based identification system (DNA barcoding) founded on the mitochondrial gene cytochrome c oxidase subunit I (COl) was investigated for updating the U.S. Food and Drug Administration Regulatory Fish Encyclopedia (RFE; http://www.cfsan.fda.gov/∼frf/rfe0.html). The RFE is a compilation of data used to identify fish species. It was compiled to help regulators identify species substitution that could result in potential adverse health consequences or could be a source of economic fraud. For each of many aquatic species commonly sold in the United States, the RFE includes high-resolution photographs of whole fish and their marketed product forms and species-specific biochemical patterns for authenticated fish species. These patterns currently include data from isoelectric focusing studies. In this article, we describe the generation of DNA barcodes for 172 individual authenticated fish representing 72 species from 27 families contained in the RFE. These barcode sequences can be used as an additional identification resource. In a blind study, 60 unknown fish muscle samples were barcoded, and the results were compared with the RFE barcode reference library. All 60 samples were correctly identified to species based on the barcoding data. Our study indicates that DNA barcoding can be a powerful tool for species identification and has broad potential applications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fishes
KW - Bar codes
KW - DNA
KW - Fraud
KW - United States
N1 - Accession Number: 28685762; Yancy, Haile F. 1; Email Address: haile.yancy@fda.hhs.gov; Zemlark, Tyler S. 2; Mason, Jacquline A. 3; Washington, Jewell D. 1; Tenge, Bradley J. 4; Nguyen, Ngoc-Lan T. 4; Barnett, James D. 4; Savary, Warren E. 4; Hill, Walter E. 4; Moore, Michelle M. 4; Fry, Frederick S. 5; Randolph, Spring C. 5; Rogers, Patricia L. 5; Hebert, Paul D. N. 2; Affiliations: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA; 2: Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada NIG 2WI; 3: Department of Microbiology, College of Medicine, Howard University, Washington, D.C. 20059, USA; 4: U.S. Food and Drug Administration, Office of Regulatory Affairs, Seafood Products Research Center, Bothell, Washington 98021, USA; 5: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland 20740, USA; Issue Info: Jan2008, Vol. 71 Issue 1, p210; Thesaurus Term: Fishes; Subject Term: Bar codes; Subject Term: DNA; Subject Term: Fraud; Subject: United States; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105595643
T1 - Assessment of abuse-related injuries: a comparative study of forensic physicians, emergency room physicians, emergency room nurses and medical students.
AU - Reijnders UJ
AU - Giannakopoulos GF
AU - de Bruin KH
Y1 - 2008/01//
N1 - Accession Number: 105595643. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 101300022.
KW - Clinical Competence
KW - Domestic Violence
KW - Nursing Staff, Hospital
KW - Physicians
KW - Students, Medical
KW - Wounds and Injuries -- Etiology
KW - Adult
KW - Emergency Medicine
KW - Emergency Nursing
KW - Female
KW - Forensic Medicine
KW - Male
KW - Middle Age
KW - Netherlands
KW - Photography
KW - Questionnaires
KW - Wounds and Injuries -- Diagnosis
KW - Human
SP - 15
EP - 19
JO - Journal of Forensic & Legal Medicine
JF - Journal of Forensic & Legal Medicine
JA - J FORENSIC LEGAL MED
VL - 15
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 1752-928X
AD - Municipal Public Health Service, Department of Forensic Medicine, Postbus 2200, 1000 CE Amsterdam, The Netherlands. ureijnders@ggd.amsterdam.nl
U2 - PMID: 17011810.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105595643&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Borger, Christine
AU - Rutherford, Thomas F.
AU - Won, Gregory Y.
AD - Centers for Medicare and Medicaid Services, US Department of Health and Human Services
AD - U CO
AD - Centers for Medicare and Medicaid Services, US Department of Health and Human Services
T1 - Projecting Long Term Medical Spending Growth
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2008/01//
VL - 27
IS - 1
SP - 69
EP - 88
SN - 01676296
N1 - Accession Number: 0957037; Keywords: Forecast; Medicare; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200803
N2 - We present a dynamic general equilibrium model of the U.S. economy and the medical sector in which the adoption of new medical treatments is endogenous and the demand for medical services is conditional on the state of technology. We use this model to prepare 75-year medical spending forecasts and a projection of the Medicare actuarial balance, and we compare our results to those obtained from a method that has been used by government actuaries. Our baseline forecast predicts slower health spending growth in the long run and a lower Medicare actuarial deficit relative to the previous projection methodology.
KW - Forecasting Models; Simulation Methods C53
KW - National Government Expenditures and Health H51
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://www.sciencedirect.com/science/journal/01676296
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=0957037&site=ehost-live&scope=site
UR - http://dx.doi.org/10.1016/j.jhealeco.2007.03.003
UR - http://www.sciencedirect.com/science/journal/01676296
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 105901625
T1 - Projecting long term medical spending growth.
AU - Borger C
AU - Rutherford TF
AU - Won GY
Y1 - 2008/01//
N1 - Accession Number: 105901625. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Health Services Administration; Peer Reviewed. NLM UID: 8410622.
KW - Health Care Costs -- Trends
KW - Medicare -- Economics
KW - Models, Statistical
KW - Economics -- Trends
KW - Forecasting
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Care Industry -- Statistics and Numerical Data
KW - Health Care Industry -- Trends
KW - Medicare -- Trends
KW - Survival Analysis
KW - Technology, Medical -- Economics
KW - Technology, Medical -- Trends
KW - United States
KW - Human
SP - 69
EP - 88
JO - Journal of Health Economics
JF - Journal of Health Economics
JA - J HEALTH ECON
VL - 27
IS - 1
PB - Elsevier Science
SN - 0167-6296
AD - Office of the Actuary, Centers for Medicare and Medicaid Services, US Department of Health and Human Services, USA.
U2 - PMID: 17459502.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105901625&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105725107
T1 - Web evaluation at the US National Institutes of Health: use of the American Customer Satisfaction Index online customer survey.
AU - Wood FB
AU - Siegel ER
AU - Feldman S
AU - Love CB
AU - Rodrigues D
AU - Malamud M
AU - Lagana M
AU - Crafts J
Y1 - 2008/01//
N1 - Accession Number: 105725107. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Canada; Computer/Information Science; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. Special Interest: Informatics. NLM UID: 100959882.
KW - Consumer Satisfaction
KW - Data Collection Methods
KW - Data Collection -- Standards
KW - Internet
KW - National Institutes of Health (U.S.)
KW - United States
KW - Human
SP - e4
EP - e4
JO - Journal of Medical Internet Research
JF - Journal of Medical Internet Research
JA - J MED INTERNET RES
VL - 10
IS - 1
CY - Toronto, Ontario
PB - JMIR Publications Inc.
AB - BACKGROUND: The National Institutes of Health (NIH), US Department of Health and Human Services (HHS), realized the need to better understand its Web users in order to help assure that websites are user friendly and well designed for effective information dissemination. A trans-NIH group proposed a trans-NIH project to implement an online customer survey, known as the American Customer Satisfaction Index (ACSI) survey, on a large number of NIH websites-the first 'enterprise-wide' ACSI application, and probably the largest enterprise Web evaluation of any kind, in the US government. The proposal was funded by the NIH Evaluation Set-Aside Program for two years at a cost of US $1.5 million (US $1.275 million for survey licenses for 60 websites at US $18000 per website; US $225,000 for a project evaluation contractor). OBJECTIVE: The overall project objectives were to assess the value added to the participating NIH websites of using the ACSI online survey, identify any NIH-wide benefits (and limitations) of the ACSI, ascertain any new understanding about the NIH Web presence based on ACSI survey results, and evaluate the effectiveness of a trans-NIH approach to Web evaluation. This was not an experimental study and was not intended to evaluate the ACSI survey methodology, per se, or the impacts of its use on customer satisfaction with NIH websites. METHODS: The evaluation methodology included baseline pre-project websites profiles; before and after email surveys of participating website teams; interviews with a representative cross-section of website staff; observations of debriefing meetings with website teams; observations at quarterly trans-NIH Web staff meetings and biweekly trans-NIH leadership team meetings; and review and analysis of secondary data. RESULTS: Of the original 60 NIH websites signed up, 55 implemented the ACSI survey, 42 generated sufficient data for formal reporting of survey results for their sites, and 51 completed the final project survey. A broad cross-section of websites participated, and a majority reported significant benefits and new knowledge gained from the ACSI survey results. NIH websites as a group scored consistently higher on overall customer satisfaction relative to US government-wide and private sector benchmarks. CONCLUSIONS: Overall, the enterprise-wide experiment was successful. On the level of individual websites, the project confirmed the value of online customer surveys as a Web evaluation method. The evaluation results indicated that successful use of the ACSI, whether site-by-site or enterprise-wide, depends in large part on strong staff and management support and adequate funding and time for the use of such evaluative methods. In the age of Web-based e-government, a broad commitment to Web evaluation may well be needed. This commitment would help assure that the potential of the Web and other information technologies to improve customer and citizen satisfaction is fully realized.
SN - 1438-8871
AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20894, USA. fredwood@mail.nih.gov
U2 - PMID: 18276580.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105725107&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105816943
T1 - The challenge of comparative effectiveness: getting the right information to the right people at the right time.
AU - Coopey M
AU - James MD
AU - Lawrence W
AU - Clancy CM
Y1 - 2008/01//Jan-Mar2008
N1 - Accession Number: 105816943. Language: English. Entry Date: 20080307. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Quality Assurance. NLM UID: 9200672.
KW - Health Care Delivery
KW - Quality of Health Care
KW - Decision Making
KW - Outcomes Research
KW - Professional Practice, Evidence-Based
KW - Quality of Care Research
KW - United States Agency for Healthcare Research and Quality
SP - 1
EP - 5
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 23
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 18281868.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105816943&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hein, Misty J.
AU - Waters, Martha A.
AU - Van Wijngaarden, Edwin
AU - Deddens, James A.
AU - Stewart, Patricia A.
T1 - Issues When Modeling Benzene, Toluene, and Xylene Exposures Using a Literature Database.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/01//
VL - 5
IS - 1
M3 - Article
SP - 36
EP - 47
PB - Taylor & Francis Ltd
SN - 15459624
AB - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource(s): a PDF file of QQ plots and a Word file with references used in the benzene/toluene/xylene exposure database.] [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Benzene
KW - Toluene
KW - Xylene
KW - Ventilation
KW - Occupational hazards
KW - Industrial hygiene
KW - Environmental health
KW - Industrial safety
KW - Work environment
KW - case control studies
KW - exposure assessment
KW - exposure determinants
KW - occupational exposure
N1 - Accession Number: 32092778; Hein, Misty J. 1; Email Address: MHein@cdc.gov; Waters, Martha A. 1; Van Wijngaarden, Edwin 2; Deddens, James A. 1,3; Stewart, Patricia A. 4; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.; 2: Department of Community and Preventive Medicine, University of Rochester, Rochester, New York.; 3: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio.; 4: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.; Issue Info: Jan2008, Vol. 5 Issue 1, p36; Thesaurus Term: Benzene; Thesaurus Term: Toluene; Thesaurus Term: Xylene; Thesaurus Term: Ventilation; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Thesaurus Term: Industrial safety; Subject Term: Work environment; Author-Supplied Keyword: case control studies; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: exposure determinants; Author-Supplied Keyword: occupational exposure; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 12p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/15459620701763947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092778&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McKernan, Lauralynn Taylor
AU - Hein, Misty J.
AU - Wallingford, Kenneth M.
AU - Burge, Harriet
AU - Herrick, Robert
T1 - Assessing Total Fungal Concentrations on Commercial Passenger Aircraft Using Mixed-Effects Modeling.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/01//
VL - 5
IS - 1
M3 - Article
SP - 48
EP - 58
PB - Taylor & Francis Ltd
SN - 15459624
AB - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n = 12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value < 0.0001) and inside the aircraft (p-value < 0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungi
KW - Airline industry
KW - Carbon dioxide
KW - Ventilation
KW - Air travel
KW - Airport terminals
KW - Air travelers
KW - Sampling (Process)
KW - Analysis of covariance
KW - aircraft
KW - culturable fungi
KW - mixed effects models
KW - total fungi
KW - total spore fungi
N1 - Accession Number: 32092779; McKernan, Lauralynn Taylor 1,2; Email Address: lmckernan@cdc.gov; Hein, Misty J. 1; Wallingford, Kenneth M. 1; Burge, Harriet 2; Herrick, Robert 2; Affiliations: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio.; 2: Harvard School of Public Health, Department of Environmental Health, Boston, Massachusetts.; Issue Info: Jan2008, Vol. 5 Issue 1, p48; Thesaurus Term: Fungi; Thesaurus Term: Airline industry; Thesaurus Term: Carbon dioxide; Thesaurus Term: Ventilation; Subject Term: Air travel; Subject Term: Airport terminals; Subject Term: Air travelers; Subject Term: Sampling (Process); Subject Term: Analysis of covariance; Author-Supplied Keyword: aircraft; Author-Supplied Keyword: culturable fungi; Author-Supplied Keyword: mixed effects models; Author-Supplied Keyword: total fungi; Author-Supplied Keyword: total spore fungi; NAICS/Industry Codes: 481211 Nonscheduled Chartered Passenger Air Transportation; NAICS/Industry Codes: 481111 Scheduled Passenger Air Transportation; NAICS/Industry Codes: 481110 Scheduled air transportation; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 11p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/15459620701766817
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105900114
T1 - Issues when modeling benzene, toluene, and xylene exposures using a literature database.
AU - Hein MJ
AU - Waters MA
AU - van Wijngaarden E
AU - Deddens JA
AU - Stewart PA
Y1 - 2008/01//
N1 - Accession Number: 105900114. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Benzene Derivatives -- Analysis
KW - Hydrocarbons, Aromatic -- Analysis
KW - Models, Theoretical
KW - Occupational Exposure -- Analysis
KW - Solvents -- Analysis
KW - Reproducibility of Results
KW - Resource Databases
KW - Human
SP - 36
EP - 47
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource(s): a PDF file of QQ plots and a Word file with references used in the benzene/toluene/xylene exposure database.].
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
U2 - PMID: 18041643.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900114&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105900115
T1 - Assessing total fungal concentrations on commercial passenger aircraft using mixed-effects modeling.
AU - McKernan LT
AU - Hein MJ
AU - Wallingford KM
AU - Burge H
AU - Herrick R
Y1 - 2008/01//
N1 - Accession Number: 105900115. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants
KW - Aircraft
KW - Fungi
KW - Air Pollution, Indoor -- Analysis
KW - Colony Count, Microbial
KW - Environmental Monitoring
KW - Models, Statistical
SP - 48
EP - 58
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n = 12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value < 0.0001) and inside the aircraft (p-value < 0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak.
SN - 1545-9624
AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio.
U2 - PMID: 18041644.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900115&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sangwoo Tak
AU - Calvert, Geoffrey M.
T1 - Hearing Difficulty Attributable to Employment by Industry and Occupation: An Analysis of the National Health Interview Survey—United States, 1997 to 2003.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/01//
VL - 50
IS - 1
M3 - Article
SP - 46
EP - 56
SN - 10762752
AB - The article presents information on the occurrence of occupational hearing loss which may attributed to employment by industry and occupation. A discussion on the efforts for the prevention of hearing loss is also provided. The article is said to be aimed at estimating the national burden of hearing difficulty among workers in the industries and occupations in the United States. The factors that cause occupational hearing loss and sesorineural hearing loss are mentioned which includes excessive noise exposure and barotrauma. The article also provides a statistical analysis of the prevalence of hearing difficulty in the United States work force.
KW - OCCUPATIONAL diseases -- Risk factors
KW - OCCUPATIONAL diseases -- Prevention
KW - DEAFNESS -- Prevention
KW - NOISE-induced deafness
KW - AURAL barotrauma
KW - NOISE pollution
KW - HEARING disorders -- Social aspects
KW - EAR diseases
KW - UNITED States
N1 - Accession Number: 29408707; Sangwoo Tak 1,2; Email Address: stak@cdc.gov Calvert, Geoffrey M. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Ga.; Source Info: Jan2008, Vol. 50 Issue 1, p46; Subject Term: OCCUPATIONAL diseases -- Risk factors; Subject Term: OCCUPATIONAL diseases -- Prevention; Subject Term: DEAFNESS -- Prevention; Subject Term: NOISE-induced deafness; Subject Term: AURAL barotrauma; Subject Term: NOISE pollution; Subject Term: HEARING disorders -- Social aspects; Subject Term: EAR diseases; Subject Term: UNITED States; Number of Pages: 11p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1097/JOM.0b013e3181579316
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=29408707&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105862457
T1 - Hearing difficulty attributable to employment by industry and occupation: an analysis of the National Health Interview Survey--United States, 1997 to 2003.
AU - Tak S
AU - Calvert GM
Y1 - 2008/01//
N1 - Accession Number: 105862457. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: National Health Interview Survey (NHIS). NLM UID: 9504688.
KW - Hearing Loss, Sensorineural -- Epidemiology
KW - Occupational Diseases -- Epidemiology
KW - Occupations and Professions
KW - Adult
KW - Cross Sectional Studies
KW - Employment
KW - Female
KW - Industry
KW - Interview Guides
KW - Male
KW - Middle Age
KW - Prevalence
KW - Surveys
KW - United States
KW - Human
SP - 46
EP - 56
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 50
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: To estimate the national burden of hearing difficulty among workers in US industries and occupations. METHODS: Data on 130,102 employed National Health Interview Survey respondents between the ages of 18 to 65 years who were interviewed between 1997 and 2003 were analyzed to estimate the population prevalence, adjusted prevalence ratios, and fractions of hearing difficulty attributable to employment. RESULTS: The estimated population prevalence of hearing difficulty was 11.4% (24% attributable to employment). The adjusted prevalence ratios of hearing difficulty were highest for railroads, mining, and primary metal manufacturing industry. Occupations with increased risk of hearing difficulty were mechanics/repairers, machine operators, and transportation equipment operators. CONCLUSIONS: Hearing difficulty was differentially distributed across various industries. In industries with high rates, employers and workers should take preventive action to reduce the risk of occupational hearing loss.
SN - 1076-2752
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. stak@cdc.gov
U2 - PMID: 18188081.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105862457&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105701918
T1 - Postural support by a standing aid alleviating subjective discomfort among cooks in a forward-bent posture during food preparation.
AU - Iwakiri K
AU - Kunisue R
AU - Sotoyama M
AU - Udo H
Y1 - 2008/01//2008 Jan
N1 - Accession Number: 105701918. Language: English. Entry Date: 20081128. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Asia; Biomedical. NLM UID: 9616320.
KW - Food Handling
KW - Low Back Pain -- Prevention and Control
KW - Occupational Diseases -- Prevention and Control
KW - Occupational Health
KW - Orthoses
KW - Adult
KW - Aged
KW - Biomechanics
KW - Body Height -- Physiology
KW - Clinical Trials
KW - Cooking
KW - Equipment Design
KW - Ergonomics
KW - Female
KW - Middle Age
KW - Nursing Homes
KW - Pain Measurement
KW - Human
SP - 57
EP - 62
JO - Journal of Occupational Health
JF - Journal of Occupational Health
JA - J OCCUP HEALTH
VL - 50
IS - 1
PB - Kyorinsha
SN - 1341-9145
AD - National Institute of Occupational Safety and Health, Kawasaki, Japan. iwakiri@h.jniosh.go.jp
U2 - PMID: 18285645.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105701918&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105884131
T1 - Intervention effectiveness evaluation criteria: promoting competitions and raising the bar.
AU - Scharf T
AU - Chapman L
AU - Collins J
AU - Limanowski J
AU - Heaney C
AU - Goldenhar LM
Y1 - 2008/01//
N1 - Accession Number: 105884131. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9612485.
KW - Competitive Behavior
KW - Evaluation Research
KW - Health Promotion
KW - Program Evaluation -- Standards
KW - Congresses and Conferences
KW - Occupational Health
SP - 1
EP - 9
JO - Journal of Occupational Health Psychology
JF - Journal of Occupational Health Psychology
JA - J OCCUP HEALTH PSYCHOL
VL - 13
IS - 1
CY - Washington, District of Columbia
PB - American Psychological Association
SN - 1076-8998
AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. tscharf@cdc.gov
U2 - PMID: 18211164.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105884131&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Scharf, Ted
AU - Chapman, Larry
AU - Collins, Jim
AU - Limanowski, Julia
AU - Heaney, Cathy
AU - Goldenhar, Linda M.
T1 - Intervention Effectiveness Evaluation Criteria: Promoting Competitions and Raising the Bar.
JO - Journal of Occupational Health Psychology
JF - Journal of Occupational Health Psychology
Y1 - 2008/01//
VL - 13
IS - 1
M3 - Article
SP - 1
EP - 9
SN - 10768998
AB - The article discusses the evaluation criteria used in two competitions, the Intervention Evaluation Competition at the Work, Stress, and Health conference in Miami, Florida held in March 2006 and the "Best Practices Evaluation Competition," which was included in the March 2008 Work, Stress, and Health conference in Washington, D.C. It details the development of the criteria with the science of evaluation methodology.
KW - INDUSTRIAL safety
KW - BEST practices
KW - INDUSTRIAL hygiene
KW - CONFERENCES & conventions
KW - UNITED States
KW - conference competitions
KW - intervention evaluation criteria
KW - occupational safety and health interventions
N1 - Accession Number: 30000602; Scharf, Ted 1; Email Address: tscharf@cdc.gov; Chapman, Larry 2; Collins, Jim 1; Limanowski, Julia 1; Heaney, Cathy 3; Goldenhar, Linda M. 4; Affiliations: 1: National Institute for Occupational Safety and Health, Ohio; 2: University of Wisconsin-Madison; 3: Stanford University; 4: University of Cincinnati College of Medicine; Issue Info: Jan2008, Vol. 13 Issue 1, p1; Thesaurus Term: INDUSTRIAL safety; Thesaurus Term: BEST practices; Thesaurus Term: INDUSTRIAL hygiene; Thesaurus Term: CONFERENCES & conventions; Subject: UNITED States; Author-Supplied Keyword: conference competitions; Author-Supplied Keyword: intervention evaluation criteria; Author-Supplied Keyword: occupational safety and health interventions; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 9p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1037/1076-8998.13.1.1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=30000602&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Lee, Karen C.
AU - Shults, Ruth A.
AU - Greenspan, Arlene I.
AU - Haileyesus, Tadesse
AU - Dellinger, Ann M.
T1 - Child passenger restraint use and emergency department–reported injuries: A special study using the National Electronic Injury Surveillance System–All Injury Program, 2004
JO - Journal of Safety Research
JF - Journal of Safety Research
Y1 - 2008/01//
VL - 39
IS - 1
M3 - Article
SP - 25
EP - 31
SN - 00224375
AB - Abstract: Introduction: In 2004, more than 180,000 child passengers aged ≤12 years sought care in U.S. hospital emergency departments (EDs) for injuries sustained in motor-vehicle crashes (MVCs). Method: We expanded the National Electronic Injury Surveillance System–All Injury Program for 635 injured children aged ≤12 years treated at 15 hospital EDs in 2004 by collecting multiple injury diagnoses and interviewing parents about MVC circumstances. Results: Nine percent of the children were unrestrained and 36% were inappropriately restrained. Blacks and Hispanics were about six times more likely to be unrestrained than Non–Hispanic Whites (12% and 14%, respectively, vs. 2%). Seventy–seven percent of inappropriate restraint use occurred among children aged 4–8 years, who were prematurely placed in seatbelts. Eight percent of children required hospitalization; unrestrained children were three times more likely to be hospitalized than restrained children (21% vs. 7%). Conclusion: Age–appropriate restraint use should be promoted for child passengers, particularly among Blacks, Hispanics, and children riding in trucks. [Copyright &y& Elsevier]
AB - Copyright of Journal of Safety Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Children's accidents
KW - Emergency medical services
KW - Hospital care
KW - United States
KW - Child passengers
KW - Motor vehicles
N1 - Accession Number: 31258945; Lee, Karen C. 1,2,3; Shults, Ruth A. 1,2; Email Address: rshults@cdc.gov; Greenspan, Arlene I. 1; Haileyesus, Tadesse 4; Dellinger, Ann M. 1; Affiliations: 1: Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control (NCIPC), Centers for Disease Control and Prevention (CDC); 2: US Public Health Service; 3: Epidemic Intelligence Service, CDC; 4: Office of Statistics and Programming, NCIPC, CDC; Issue Info: Jan2008, Vol. 39 Issue 1, p25; Subject Term: Children's accidents; Subject Term: Emergency medical services; Subject Term: Hospital care; Subject: United States; Author-Supplied Keyword: Child passengers; Author-Supplied Keyword: Motor vehicles; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 913130 Municipal police services; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jsr.2007.10.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31258945&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sahakian, Nancy M.
AU - White, Sandra K.
AU - Park, Ju-Hyeong
AU - Cox-Ganser, Jean M.
AU - Kreiss, Kathleen
T1 - Identification of Mold and Dampness-Associated Respiratory Morbidity in 2 Schools: Comparison of Questionnaire Survey Responses to National Data.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2008/01//
VL - 78
IS - 1
M3 - Article
SP - 32
EP - 37
PB - Wiley-Blackwell
SN - 00224391
AB - Background: Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students. Methods: School employees (n = 309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Results: Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections. Conclusions: This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of School Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health research
KW - ENVIRONMENTAL health
KW - CHRONIC diseases
KW - SCHOOLS -- Environmental aspects
KW - MOLDS (Fungi)
KW - ENVIRONMENTAL risk assessment
KW - DAMPNESS in buildings
KW - SCHOOL buildings -- Environmental aspects
KW - INDOOR air pollution
KW - chronic diseases
KW - chronic diseases.
KW - environmental health
KW - public health
N1 - Accession Number: 27974276; Sahakian, Nancy M. 1; Email Address: nsahakian@cdc.gov White, Sandra K. 2; Email Address: swhite4@cdc.gov Park, Ju-Hyeong 3; Email Address: jpark2@cdc.gov Cox-Ganser, Jean M. 2; Email Address: jcoxganser@cdc.gov Kreiss, Kathleen 4; Email Address: kkreiss@cdc.gov; Affiliation: 1: Medical Officer, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505 2: Epidemiologist, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505 3: Environmental Health Scientist, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505 4: Field Studies Branch Chief, National Institute For Occupational Safety And Health, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505; Source Info: Jan2008, Vol. 78 Issue 1, p32; Subject Term: PUBLIC health research; Subject Term: ENVIRONMENTAL health; Subject Term: CHRONIC diseases; Subject Term: SCHOOLS -- Environmental aspects; Subject Term: MOLDS (Fungi); Subject Term: ENVIRONMENTAL risk assessment; Subject Term: DAMPNESS in buildings; Subject Term: SCHOOL buildings -- Environmental aspects; Subject Term: INDOOR air pollution; Author-Supplied Keyword: chronic diseases; Author-Supplied Keyword: chronic diseases.; Author-Supplied Keyword: environmental health; Author-Supplied Keyword: public health; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 611699 All Other Miscellaneous Schools and Instruction; NAICS/Industry Codes: 611110 Elementary and Secondary Schools; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1746-1561.2007.00263.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27974276&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105876632
T1 - Identification of mold and dampness-associated respiratory morbidity in 2 schools: comparison of questionnaire survey responses to national data.
AU - Sahakian NM
AU - White SK
AU - Park J
AU - Cox-Ganser JM
AU - Kreiss K
Y1 - 2008/01//
N1 - Accession Number: 105876632. Language: English. Entry Date: 20080404. Revision Date: 20150820. Publication Type: Journal Article; case study; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Pediatric Care. Instrumentation: Building Assessment Survey and Evaluation (BASE); National Health and Nutrition Examination Survey (NHANES III). NLM UID: 0376370.
KW - Air Pollution, Indoor
KW - Fungi
KW - Occupational Diseases -- Epidemiology
KW - Respiratory Tract Diseases -- Epidemiology
KW - Schools, Elementary
KW - Administrative Personnel
KW - Adult
KW - Asthma
KW - Case Studies
KW - Comparative Studies
KW - Confidence Intervals
KW - Connecticut
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Fatigue
KW - Female
KW - Headache
KW - Interior Design and Furnishings
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Self Report
KW - Skin Diseases
KW - Smoking
KW - South Carolina
KW - Surveys
KW - Teachers
KW - Ventilation
KW - Human
SP - 32
EP - 37
JO - Journal of School Health
JF - Journal of School Health
JA - J SCH HEALTH
VL - 78
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background: Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students. Methods: School employees (n = 309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Results: Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections. Conclusions: This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited.
SN - 0022-4391
AD - Epidemiologist, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505.
U2 - PMID: 18177298.
DO - 10.1111/j.1746-1561.2007.00263.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105876632&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105561257
T1 - Policy and practice implications of epidemiological surveys on co-occurring mental and substance use disorders.
AU - Clark HW
AU - Power AK
AU - Le Fauve CE
AU - Lopez EI
Y1 - 2008/01//
N1 - Accession Number: 105561257. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. NLM UID: 8500909.
KW - Health Policy
KW - Mental Disorders -- Epidemiology
KW - Mental Health Services -- Legislation and Jurisprudence
KW - Questionnaires
KW - Substance Use Disorders -- Epidemiology
KW - Comorbidity
KW - Employment
KW - Public Health -- Legislation and Jurisprudence
KW - Social Work -- Legislation and Jurisprudence
KW - United States
SP - 3
EP - 13
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
JA - J SUBST ABUSE TREAT
VL - 34
IS - 1
PB - Pergamon Press - An Imprint of Elsevier Science
SN - 0740-5472
AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD 20857, USA. westley.clark@samhsa.hhs.gov
U2 - PMID: 17574794.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105561257&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Azad, Neelam
AU - Rojanasakul, Yon
AU - Vallyathan, Val
T1 - Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species.
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2008/01//
VL - 11
IS - 1
M3 - Article
SP - 1
EP - 15
SN - 10937404
AB - The lung is a highly specialized organ that facilitates uptake of oxygen and release of carbon dioxide. Due to its unique structure providing enormous surface area to outside ambient air, it is vulnerable to numerous pathogens, pollutants, oxidants, gases, and toxicants that are inhaled continuously from air, which makes the lung susceptible to varying degrees of oxidative injury. To combat these unrelenting physical, chemical, and biological insults, the respiratory epithelium is covered with a thin layer of lining fluid containing several antioxidants and surfactants. Inhaled toxic agents stimulate the generation of reactive oxygen/nitrogen species (ROS/RNS), which in turn provoke inflammatory responses resulting in the release of proinflammatory cytokines and chemokines. These subsequently stimulate the influx of polymorphonuclear leukocytes (PMNs) and monocytes into the lung so as to combat the invading pathogens or toxic agents. In addition to the beneficial effects, persistent inhalation of the invading pathogens or toxic agents may result in overwhelming production of ROS/RNS, producing chronic inflammation and lung injury. During inflammation, enhanced ROS/RNS production may induce recurring DNA damage, inhibition of apoptosis, and activation of proto-oncogenes by initiating signal transduction pathways. Therefore, it is conceivable that chronic inflammation-induced production of ROS/RNS in the lung may predispose individuals to lung cancer. This review describes the complex relationship between lung inflammation and carcinogenesis, and highlights the role of ROS/RNS in cancer development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS
KW - PATHOGENIC microorganisms
KW - LUNGS -- Cancer
KW - EPITHELIUM
KW - LEUCOCYTES
KW - INFLAMMATION -- Mediators
KW - CANCER genetics
KW - OXYGEN
KW - PATHOLOGY
N1 - Accession Number: 28111336; Azad, Neelam 1 Rojanasakul, Yon 1 Vallyathan, Val 2; Email Address: vav1@cdc.gov; Affiliation: 1: Department of Pharmaceutical and Pharmacological Sciences, West Virginia University, Morgantown, West Virginia, USA 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Jan2008, Vol. 11 Issue 1, p1; Subject Term: LUNGS; Subject Term: PATHOGENIC microorganisms; Subject Term: LUNGS -- Cancer; Subject Term: EPITHELIUM; Subject Term: LEUCOCYTES; Subject Term: INFLAMMATION -- Mediators; Subject Term: CANCER genetics; Subject Term: OXYGEN; Subject Term: PATHOLOGY; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 15p; Illustrations: 3 Diagrams; Document Type: Article
L3 - 10.1080/10937400701436460
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Jeffrey S.
AU - Xu, Zhili
AU - Byrnes, Andrew P.
T1 - A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008/01//
VL - 147
IS - 1
M3 - Article
SP - 54
EP - 60
SN - 01660934
AB - Abstract: Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad. A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and computerized image analysis. The method is sensitive, quantitative and reproducible, with a linear range spanning two orders of magnitude. As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER cells
KW - MICROSCOPY
KW - MACROPHAGES
KW - CELLS
KW - Adenovirus
KW - Confocal microscopy
KW - Image analysis
KW - Kupffer cells
N1 - Accession Number: 27942657; Smith, Jeffrey S. 1; Email Address: JeffreyS.Smith@fda.hhs.gov Xu, Zhili 1; Email Address: Zhili.Xu@fda.hhs.gov Byrnes, Andrew P.; Email Address: Andrew.Byrnes@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA; Source Info: Jan2008, Vol. 147 Issue 1, p54; Subject Term: LIVER cells; Subject Term: MICROSCOPY; Subject Term: MACROPHAGES; Subject Term: CELLS; Author-Supplied Keyword: Adenovirus; Author-Supplied Keyword: Confocal microscopy; Author-Supplied Keyword: Image analysis; Author-Supplied Keyword: Kupffer cells; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2007.08.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Wu, John Z.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
T1 - A new approach to characterize grip force applied to a cylindrical handle
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
Y1 - 2008/01//
VL - 30
IS - 1
M3 - Article
SP - 20
EP - 33
SN - 13504533
AB - Abstract: The grip force applied to a cylindrical handle is a function of the measurement reference axis. So far, however, no attempt has been made to fully describe the exact form of this function. The objectives of this study were to examine some fundamental characteristics of grip forces and to explore the basic pattern of the grip force function. Twenty subjects (10 males and 10 females) participated in the experiment. The subjects alternately used their left and right hands to apply maximum grip forces and medium grip forces (about 40% of maximum) to a 30mm handle. A flexible pressure sensor mat was used to measure the grip pressure. The pressure was integrated with respect to different measurement axes; this resulted in the grip force function. This study found that every gripping action produces maximum and minimum force axes; these axes are separated by about 90°. The maximum force is correlated with the minimum force, but the former is generally about 1.42 times the latter. The principal grip direction is about 78° from the z h-axis of the hand biodynamic coordinate system defined in ISO 8727 [ISO 8727. Mechanical vibration and shock – human exposure – biodynamic coordinate systems. Geneva, Switzerland: International Organization for Standardization; 1997]. More interestingly, each of the 160 sets of experimental data reasonably fit this study''s proposed elliptical model. The implications of the findings are discussed. [Copyright &y& Elsevier]
AB - Copyright of Medical Engineering & Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYLINDRIC algebras
KW - PRESSURE transducers
KW - AXES
KW - MEDICAL research
KW - Grip force
KW - Grip pressure
KW - Grip strength
KW - Hand
KW - Hand force
N1 - Accession Number: 28405405; Dong, Ren G.; Email Address: rkd6@cdc.gov Wu, John Z. 1 Welcome, Daniel E. 1 McDowell, Thomas W. 1; Affiliation: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA; Source Info: Jan2008, Vol. 30 Issue 1, p20; Subject Term: CYLINDRIC algebras; Subject Term: PRESSURE transducers; Subject Term: AXES; Subject Term: MEDICAL research; Author-Supplied Keyword: Grip force; Author-Supplied Keyword: Grip pressure; Author-Supplied Keyword: Grip strength; Author-Supplied Keyword: Hand; Author-Supplied Keyword: Hand force; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.medengphy.2007.01.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ramalingam, Thirumalai R
AU - Pesce, John T
AU - Sheikh, Faruk
AU - Cheever, Allen W
AU - Mentink-Kane, Margaret M
AU - Wilson, Mark S
AU - Stevens, Sean
AU - Valenzuela, David M
AU - Murphy, Andrew J
AU - Yancopoulos, George D
AU - Urban, Joseph F
AU - Donnelly, Raymond P
AU - Wynn, Thomas A
T1 - Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain.
JO - Nature Immunology
JF - Nature Immunology
Y1 - 2008/01//
VL - 9
IS - 1
M3 - Article
SP - 25
EP - 33
PB - Nature Publishing Group
SN - 15292908
AB - The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (TH2)–mediated disease and associates with either the common γ-chain to form the type I IL-4R or with the IL-13R α1 chain (IL-13Rα1) to form the type II IL-4R. Here we used Il13ra1−/− mice to characterize the distinct functions of type I and type II IL-4 receptors in vivo. In contrast to Il4ra−/− mice, which have weak TH2 responses, Il13ra1−/− mice had exacerbated TH2 responses. Il13ra1−/− mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis. IL-13Rα1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation. Thus, type I and II IL-4 receptors exert distinct effects on immune responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Immunology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 27948491; Ramalingam, Thirumalai R 1 Pesce, John T 1 Sheikh, Faruk 2 Cheever, Allen W 3 Mentink-Kane, Margaret M 1 Wilson, Mark S 1 Stevens, Sean 4 Valenzuela, David M 4 Murphy, Andrew J 4 Yancopoulos, George D 4 Urban, Joseph F 5 Donnelly, Raymond P 2 Wynn, Thomas A 1; Affiliation: 1: Laboratory of Parasitic Diseases, National institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. 2: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. 3: Biomedical Research Institute, Rockville, Maryland 20852, USA. 4: Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA. 5: Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705, USA.; Source Info: Jan2008, Vol. 9 Issue 1, p25; Number of Pages: 9p; Illustrations: 1 Diagram, 8 Graphs; Document Type: Article
L3 - 10.1038/ni1544
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Welcome, Daniel E.
AU - Wu, John Z.
AU - McDowell, Thomas W.
T1 - Development of hand-arm system models for vibrating tool analysis and test rig construction.
JO - Noise Control Engineering Journal
JF - Noise Control Engineering Journal
Y1 - 2008/01//Jan/Feb2008
VL - 56
IS - 1
M3 - Article
SP - 35
EP - 44
PB - Institute of Noise Control Engineering of the USA
SN - 07362501
AB - The vibration and noise generated by powered hand tools may be affected by human interaction with these tools. This effect can be taken into account by including a hand-arm system model in tool analysis and testing. The objective of this study is to propose a general methodology for developing practical models for tool analyses and test rig constructions. To demonstrate the methodology, this study applied three traditional models (2-, 3-, and 4-degree-of-freedom (DOF) models) as well as a new 4-DOF model proposed by the authors. The biodynamic responses to hand-transmitted vibration measured at the hand driving-point along the forearm direction under combined grip and push actions were used to determine the parameters of the models using a least root-mean-square error curve fitting method. This study found that the new 4-DOF model and the traditional 3-DOF and 4-DOF models accurately represented the experimental mechanical impedance (MI). The transmissibility functions predicted using these models were also consistent with their corresponding experimental data measured on the fingers and at the wrist. When judged using apparent mass (AM) instead of MI, the traditional 2-DOF model also fits the experimental data well. The parameters of the 2-DOF and new 4-DOF models are more reasonable than those of the other two models for test rig construction. This study concluded that the new 4-DOF model provides the best choice for analyzing tools and for constructing test rigs. However, if the hand-tool dynamic interactions below 100 Hz are of major concern, the 2-DOF model is simpler and less expensive for test rig construction. Whereas these two models can be directly used in some applications, the proposed methodology can be used to develop a more tool-specific model when biodynamic response data for the specific tool are available. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Control Engineering Journal is the property of Institute of Noise Control Engineering of the USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mathematical models
KW - Noise control
KW - Mechanical impedance
KW - Tools -- Design & construction
KW - Power tools -- Vibration
KW - Noise control -- Equipment & supplies
KW - Degrees of freedom
KW - Least squares
KW - Curve fitting
KW - Graphic methods in statistics
KW - Power tools
KW - Analysis of variance
N1 - Accession Number: 31332341; Dong, Ren G. 1; Email Address: rkd6@cdc.gov; Welcome, Daniel E. 1; Wu, John Z. 1; McDowell, Thomas W. 1; Affiliations: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown WV 26505 USA.; Issue Info: Jan/Feb2008, Vol. 56 Issue 1, p35; Thesaurus Term: Mathematical models; Thesaurus Term: Noise control; Subject Term: Mechanical impedance; Subject Term: Tools -- Design & construction; Subject Term: Power tools -- Vibration; Subject Term: Noise control -- Equipment & supplies; Subject Term: Degrees of freedom; Subject Term: Least squares; Subject Term: Curve fitting; Subject Term: Graphic methods in statistics; Subject Term: Power tools; Subject Term: Analysis of variance; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; Number of Pages: 10p; Illustrations: 2 Diagrams, 3 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Takahashi, Yukio
AU - Harada, Noriaki
T1 - A consideration of an evaluation index for high-level low-frequency noise by taking into account the effect of human body vibration.
JO - Noise Notes
JF - Noise Notes
Y1 - 2008/01//
VL - 7
IS - 1
M3 - Article
SP - 19
EP - 32
PB - Multi-Science Publishing Co Ltd
SN - 14754738
AB - At high sound pressure levels, actual body vibrations (noise-induced vibrations) are induced by low-frequency noise. The purpose of this trial study was to show that considering the effects of noise-induced vibration is effective in evaluating high-level low-frequency noise. Using the A-weighted sound pressure level and the Wk-weighted vibration acceleration level of noise-induced vibration measured on the chest as independent variables, empirical evaluation indices (HLLF1, HLLF2 and HLLF3) for evaluating the unpleasantness caused by high-level low-frequency noise were estimated. The HLLF indices were found to be able to evaluate the unpleasantness caused by high-level low-frequency noise better than the A-weighted pressure level. In addition, the slopes of tentative frequency-weighting characteristics corresponding to the HLLF indices were estimated to be gentler than that of the A-weighting characteristic within 25- 50 Hz, which was consistent with many previous results that indicated that noise content at lower frequencies should be given more importance when evaluating low-frequency noise Although there are several areas where the HLLF index needs to be improved before it is put in practical use, the results of this study suggest that high-level lowfrequency noise could be more effectively evaluated by taking into account the effect of human body vibration. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Notes is the property of Multi-Science Publishing Co Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Strains & stresses (Mechanics)
KW - Vibration (Mechanics)
KW - Sound pressure
KW - Noise
KW - Acoustic radiation pressure
KW - Ultrasonics
KW - Radio frequency
KW - Aerodynamic load
KW - Acceleration (Mechanics)
N1 - Accession Number: 31625912; Takahashi, Yukio 1; Email Address: takahay@h.jniosh.go.jp; Harada, Noriaki 2; Affiliations: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, Japan. 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Hygiene, Yamaguchi University Graduate School of Medicine. 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan; Issue Info: Jan2008, Vol. 7 Issue 1, p19; Thesaurus Term: Strains & stresses (Mechanics); Subject Term: Vibration (Mechanics); Subject Term: Sound pressure; Subject Term: Noise; Subject Term: Acoustic radiation pressure; Subject Term: Ultrasonics; Subject Term: Radio frequency; Subject Term: Aerodynamic load; Subject Term: Acceleration (Mechanics); Number of Pages: 14p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 106001031
T1 - Device safety. Waking up to hospital bed entrapment risks.
AU - Todd JF
Y1 - 2008/01//
N1 - Accession Number: 106001031. Language: English. Entry Date: 20080229. Revision Date: 20150820. Publication Type: Journal Article; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 7600137.
KW - Beds and Mattresses -- Adverse Effects
KW - Equipment Safety
KW - Patient Safety
KW - Aged, 80 and Over
KW - Equipment Design
KW - Female
KW - Inpatients
SP - 14
EP - 15
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-consultant, Center for Devices and Radiological Health.
U2 - PMID: 18160878.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Duffy, Peter H.
AU - Lewis, Sherry M.
AU - Mayhugh, Martha A.
AU - Trotter, Ronald W.
AU - Hass, Bruce S.
AU - Latendresse, John R.
AU - Thorn, Brett T.
AU - Tobin, Graham
AU - Feuers, Ritchie J.
T1 - Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2008/01//
VL - 28
IS - 1
M3 - Article
SP - 36
EP - 42
SN - 02715317
AB - Abstract: The primary purpose of this study was to evaluate the effects of age and long-term dietary reduction on neoplastic diseases in rats fed the AIN-93M purified diet. Second, pathologic profiles are critical to comprehensive dietary evaluation. Male Sprague-Dawley rats assigned to 2 groups, ad libitum (AL) and dietary restricted (DR), were fed the AIN-93M (casein protein) diet free choice and reduced in amount by 31%, respectively. At 58 weeks of age, the predominant types of lesions in AL and DR rats were pituitary and skin tumors. At 114 weeks of age, the most common lesions were pituitary, adrenal gland, skin, mammary, brain, and pancreatic tumors and mononuclear cell leukemia. However, DR had no significant effect on these lesions. Primary findings demonstrate that DR significantly reduced the total number of tumors per rat and incidence of benign and primary tumors (all organs) but did not reduce the incidence of malignant tumors (all organs). Dietary restriction increased the percentage of unknown deaths. These results may explain why survival rates for AL and DR rats were not significantly different at 114 weeks (43.3 vs 57.5%, respectively). These findings differ from previous studies using NIH-31 cereal diet (Aging Clin Exp Res 2001;13:263; J Nutr 2002;132:101; Aging Clin Exp Res 2003;16(6):68; Aging Clin Exp Res 2004;16:448) where neoplastic lesions rather than nonneoplastic lesions were linked to a significant increase in survival rate among cohorts of DR-fed rats (J Nutr 2002;132:101). Factors such as diet composition and digestibility, although not independent of body weight, may have contributed to differences in rat mortality and may affect humans in a similar manner. [Copyright &y& Elsevier]
AB - Copyright of Nutrition Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEOPLASTICISM (Art movement)
KW - ONCOLOGY
KW - DIET in disease
KW - RATS
KW - WEIGHT gain
KW - ANTHROPOMETRY
KW - AIN-93M diet
KW - Dietary
KW - Neoplastic
KW - Pathology
KW - Rat
KW - Restriction
N1 - Accession Number: 28404242; Duffy, Peter H. 1; Email Address: peter.duffy@fda.hhs.gov Lewis, Sherry M. 2 Mayhugh, Martha A. 3 Trotter, Ronald W. 4 Hass, Bruce S. 1 Latendresse, John R. 4 Thorn, Brett T. 5 Tobin, Graham 6 Feuers, Ritchie J. 7; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Office of Scientific Coordination, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: The Bionetics Corporation, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 4: Pathology Associates International, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 5: Z-TECH Corporation, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 6: Harlan Teklad, Blackthorn, Bicester OX25 1TP, UK 7: Division of Chemistry, National Center for Toxicological Research, FDA, Jefferson, AR 72079,USA; Source Info: Jan2008, Vol. 28 Issue 1, p36; Subject Term: NEOPLASTICISM (Art movement); Subject Term: ONCOLOGY; Subject Term: DIET in disease; Subject Term: RATS; Subject Term: WEIGHT gain; Subject Term: ANTHROPOMETRY; Author-Supplied Keyword: AIN-93M diet; Author-Supplied Keyword: Dietary; Author-Supplied Keyword: Neoplastic; Author-Supplied Keyword: Pathology; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Restriction; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.nutres.2007.09.018
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-00945-007
AN - 2008-00945-007
AU - Spicer, Paul
AU - Moore, Kelly
ED - Fitzgerald, Hiram E.
ED - Mousouli, Vasiliki
ED - Davies, H. Dele
ED - Fitzgerald, Hiram E., (Ed)
ED - Mousouli, Vasiliki, (Ed)
ED - Davies, H. Dele, (Ed)
T1 - Responding to the epidemic of American Indian and Alaska Native childhood obesity.
T2 - Obesity in childhood and adolescence, Vol 2: Understanding development and prevention.
T3 - Praeger perspectives: Child psychology and mental health; ISSN: 1538-8883 (Print)
Y1 - 2008///
SP - 143
EP - 166
CY - Westport, CT, US
PB - Praeger Publishers/Greenwood Publishing Group
SN - 1538-8883
SN - 978-0-275-99619-2
SN - 978-0-275-99615-4
N1 - Accession Number: 2008-00945-007. Partial author list: First Author & Affiliation: Spicer, Paul; University of Colorado, American Indian and Alaska Native Programs, CO, US. Release Date: 20080407. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-275-99619-2, Hardcover; 978-0-275-99615-4, Set. Language: English. Major Descriptor: Alaska Natives; American Indians; Body Weight; Obesity; Treatment. Minor Descriptor: Childhood Development; Community Services; Cultural Sensitivity; Government Policy Making; Government Programs; Health Promotion; Nutrition; Physical Activity; Program Development; Sociocultural Factors. Classification: Eating Disorders (3260); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 24.
AB - In this chapter we review what is known about the prevalence and correlates of childhood overweight and obesity in American Indian and Alaska Native (AI/AN) communities. We then discuss some of the possible implications of this knowledge for policy change and program development in the areas of physical activity and nutrition. While much of what we see in AI/AN communities mirrors what we see in other U.S. racial and ethnic minority populations, the specific needs of AI/AN communities will require special attention as we move towards crafting culturally effective interventions. Our strategy is to position what we know or are starting to learn about obesity in AI/AN children and youth within the context of knowledge that is emerging more generally for U.S. children. We close by describing community-directed promising practices targeting AI/AN children and youth in specific communities and nationally, through the Special Diabetes Program for Indians grant programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - childhood overweight
KW - childhood obesity
KW - American Indians
KW - Alaska Natives
KW - government policy making
KW - physical activity
KW - nutrition
KW - culturally effective interventions
KW - community services
KW - 2008
KW - Alaska Natives
KW - American Indians
KW - Body Weight
KW - Obesity
KW - Treatment
KW - Childhood Development
KW - Community Services
KW - Cultural Sensitivity
KW - Government Policy Making
KW - Government Programs
KW - Health Promotion
KW - Nutrition
KW - Physical Activity
KW - Program Development
KW - Sociocultural Factors
KW - 2008
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DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - MacDonald, L. A.
AU - Härenstam, A.
AU - Warren, N. D.
AU - Punnett, L.
T1 - Incorporating work organisation into occupational health research: an invitation for dialogue.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2008/01//
VL - 65
IS - 1
M3 - Editorial
SP - 1
EP - 3
SN - 13510711
AB - The authors focuses on the incorporation of working organization into occupational health research. They pointed out that occupational health researchers have been slowing down to incorporate broader workplace features into their exposure assessment protocols and epidemiological study designs. However, the authors are seeking to stimulate dialogue within the occupational health community about the organizational context and its implications for aetiological research and hazard control.
KW - RESEARCH
KW - Industrial hygiene
KW - Public health research
KW - Research
KW - Industrial hygiene
N1 - Accession Number: 28450018; MacDonald, L. A. 1; Email Address: Imacdonald@cdc.gov; Härenstam, A. 2; Warren, N. D. 3; Punnett, L. 4; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, OH, USA; 2: Department of Work Science, Göteborg University, Sweden; 3: Division of Public Health and Population Sciences, University of Connecticut Health Center, Farmington, CT, USA; 4: Department of Work Environment, University of Massachusetts Lowell, Lowell, MA, USA; Issue Info: Jan2008, Vol. 65 Issue 1, p1; Thesaurus Term: RESEARCH; Thesaurus Term: Industrial hygiene; Thesaurus Term: Public health research; Thesaurus Term: Research; Subject Term: Industrial hygiene; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 3p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Editorial
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shein, Mitchell J.
AU - Moynahan, Megan
T1 - FDA Viewpoint.
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
Y1 - 2008/01//
VL - 31
IS - 1
M3 - Article
SP - 16
EP - 16
PB - Wiley-Blackwell
SN - 01478389
AB - The authors praises the editors of "PACE" for publishing case studies describing the field performance of the Riata ST ICT Leads impantable cardioverter-defibrillator (ICD) from St. Jude Medical. They cite the way the U.S. Food and Drug Administration (FDA) works to identify trends from individual reports on ICD. They points to an FDA regulation requiring hospitals and other facilities to rport deaths and serious injuries associated with the use of medical devices.
KW - IMPLANTABLE cardioverter-defibrillators
KW - GOVERNMENT policy
KW - EDITORIALS
KW - UNITED States
KW - ST. Jude Medical Inc.
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 27974368; Shein, Mitchell J. 1; Email Address: mitchell.shein@fda.hhs.gov Moynahan, Megan 2; Affiliation: 1: Pacemaker Expert Center for Devices and Radiological Health US Food and Drug Administration 2: Chief, Pacing Defibrillation and Leads Branch, Center for Devices and Radiological Health, US Food and Drug Administration; Source Info: Jan2008, Vol. 31 Issue 1, p16; Subject Term: IMPLANTABLE cardioverter-defibrillators; Subject Term: GOVERNMENT policy; Subject Term: EDITORIALS; Subject Term: UNITED States; Company/Entity: ST. Jude Medical Inc. Ticker: STJ Company/Entity: UNITED States. Food & Drug Administration Ticker: ; NAICS/Industry Codes: 519110 News Syndicates; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/j.1540-8159.2007.00944.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105737973
T1 - FDA viewpoint.
AU - Shein MJ
AU - Moynahan M
Y1 - 2008/01//
N1 - Accession Number: 105737973. Language: English. Entry Date: 20080613. Revision Date: 20150711. Publication Type: Journal Article; website. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 7803944.
KW - Defibrillators, Implantable
KW - Defibrillators, Implantable -- Adverse Effects
KW - Incident Reports
KW - United States Food and Drug Administration
KW - Voluntary Reporting
KW - World Wide Web
SP - 16
EP - 16
JO - Pacing & Clinical Electrophysiology
JF - Pacing & Clinical Electrophysiology
JA - PACING CLIN ELECTROPHYSIOL
VL - 31
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0147-8389
AD - Pacemaker Expert, Center for Devices and Radiological Health, US Food and Drug Administration.
U2 - PMID: 18181904.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nurkiewicz, Timothy R.
AU - Porter, Dale W.
AU - Hubbs, Ann F.
AU - Cumpston, Jared L.
AU - Chen, Bean T.
AU - Frazer, David G.
AU - Castranova, Vincent
T1 - Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 17438977
AB - Background: We have shown that pulmonary exposure to fine particulate matter (PM) impairs endothelium dependent dilation in systemic arterioles. Ultrafine PM has been suggested to be inherently more toxic by virtue of its increased surface area. The purpose of this study was to determine if ultrafine PM (or nanoparticle) inhalation produces greater microvascular dysfunction than fine PM. Rats were exposed to fine or ultrafine TiO2 aerosols (primary particle diameters of ~1 µm and ~21 nm, respectively) at concentrations which do not alter bronchoalveolar lavage markers of pulmonary inflammation or lung damage. Results: By histopathologic evaluation, no significant inflammatory changes were seen in the lung. However, particle-containing macrophages were frequently seen in intimate contact with the alveolar wall. The spinotrapezius muscle was prepared for in vivo microscopy 24 hours after inhalation exposures. Intraluminal infusion of the Ca2+ ionophore A23187 was used to evaluate endothelium-dependent arteriolar dilation. In control rats, A23187 infusion produced dose-dependent arteriolar dilations. In rats exposed to fine TiO2, A23187 infusion elicited vasodilations that were blunted in proportion to pulmonary particle deposition. In rats exposed to ultrafine TiO2, A23187 infusion produced arteriolar constrictions or significantly impaired vasodilator responses as compared to the responses observed in control rats or those exposed to a similar pulmonary load of fine particles. Conclusion: These observations suggest that at equivalent pulmonary loads, as compared to fine TiO2, ultrafine TiO2 inhalation produces greater remote microvascular dysfunction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Particulate matter
KW - Biochemical markers
KW - Nanoparticles
KW - Microcirculation disorders
KW - Macrophages
KW - Rats as laboratory animals
KW - Vasodilation
N1 - Accession Number: 35704435; Nurkiewicz, Timothy R. 1,2; Email Address: tnurkiewicz@hsc.wvu.edu; Porter, Dale W. 2,3; Email Address: dhp7@cdc.gov; Hubbs, Ann F. 3; Email Address: afh0@cdc.gov; Cumpston, Jared L. 3; Email Address: dsv3@cdc.gov; Chen, Bean T. 3; Email Address: bdc4@cdc.gov; Frazer, David G. 2,3; Email Address: dgf1@cdc.gov; Castranova, Vincent 2,3; Email Address: vic1@cdc.gov; Affiliations: 1: Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA; 2: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Issue Info: 2008, Vol. 5, Special section p1; Thesaurus Term: Particulate matter; Thesaurus Term: Biochemical markers; Subject Term: Nanoparticles; Subject Term: Microcirculation disorders; Subject Term: Macrophages; Subject Term: Rats as laboratory animals; Subject Term: Vasodilation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Illustrations: 3 Diagrams, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1186/1743-8977-5-1
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zeidler-Erdely, Patti C.
AU - Kashon, Michael L.
AU - Battelli, Lori A.
AU - Shih-Houng Young
AU - Erdely, Aaron
AU - Roberts, Jenny R.
AU - Reynolds, Steven H.
AU - Antonini, James M.
T1 - Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 16
PB - BioMed Central
SN - 17438977
AB - Background: Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 µg of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 µg soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure. Results: BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found. Conclusion: The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenesis
KW - Pulmonary manifestations of general diseases
KW - Lung tumors
KW - Welding fumes
KW - Bronchoalveolar lavage
KW - Mice as laboratory animals
N1 - Accession Number: 35704438; Zeidler-Erdely, Patti C. 1; Email Address: paz9@cdc.gov; Kashon, Michael L. 2; Email Address: MKashon@cdc.gov; Battelli, Lori A. 1; Email Address: LBattelli@cdc.gov; Shih-Houng Young 1; Email Address: SYoung@cdc.gov; Erdely, Aaron 3; Email Address: AErdely@cdc.gov; Roberts, Jenny R. 1; Email Address: JRRoberts@cdc.gov; Reynolds, Steven H. 3; Email Address: SReynolds@cdc.gov; Antonini, James M. 1; Email Address: JAntonini@cdc.gov; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA; 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA; 3: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA; Issue Info: 2008, Vol. 5, Special section p1; Thesaurus Term: Carcinogenesis; Subject Term: Pulmonary manifestations of general diseases; Subject Term: Lung tumors; Subject Term: Welding fumes; Subject Term: Bronchoalveolar lavage; Subject Term: Mice as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 16p; Illustrations: 1 Diagram, 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1186/1743-8977-5-12
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105565405
T1 - CT colonography with computer-aided detection as a second reader: observer performance study.
AU - Petrick N
AU - Haider M
AU - Summers RM
AU - Yeshwant SC
AU - Brown L
AU - Iuliano EM
AU - Louie A
AU - Choi JR
AU - Pickhardt PJ
Y1 - 2008/01//
N1 - Accession Number: 105565405. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. Special Interest: Diagnostic Imaging. NLM UID: 0401260.
KW - Colonic Polyps -- Radiography
KW - Colonography, Computed Tomographic -- Methods
KW - Diagnosis, Computer Assisted
KW - Aged
KW - Colonic Polyps -- Diagnosis
KW - Colonoscopy
KW - Female
KW - Male
KW - Middle Age
KW - Sensitivity and Specificity
KW - Human
SP - 148
EP - 156
JO - Radiology
JF - Radiology
JA - RADIOLOGY
VL - 246
IS - 1
CY - Oak Brook, Illinois
PB - Radiological Society of North America
SN - 0033-8419
AD - National Institute of Biomedical Imaging and Bioengineering/Center for Devices and Radiological Health Joint Laboratory for the Assessment of Medical Imaging Systems, U.S. Food and Drug Administration, Rockville, MD, USA.
U2 - PMID: 18096536.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Badal, Andreu
AU - Kyprianou, Iacovos
AU - Badano, Aldo
AU - Sempau, Josep
T1 - Monte Carlo simulation of a realistic anatomical phantom described by triangle meshes: Application to prostate brachytherapy imaging
JO - Radiotherapy & Oncology
JF - Radiotherapy & Oncology
Y1 - 2008/01//
VL - 86
IS - 1
M3 - Article
SP - 99
EP - 103
SN - 01678140
AB - Abstract: Purpose: Monte Carlo codes can simulate the transport of radiation within matter with high accuracy and can be used to study medical applications of ionising radiations. The aim of our work was to develop a Monte Carlo code capable of generating projection images of the human body. In order to obtain clinically realistic images a detailed anthropomorphic phantom was prepared. These two simulation tools are intended to study the multiple applications of imaging in radiotherapy, from image guided treatments to portal imaging. Methods: We adapted the general-purpose code PENELOPE 2006 to simulate a radiation source, an ideal digital detector, and a realistic model of the patient anatomy. The anthropomorphic phantom was developed using computer-aided design tools, and is based on the NCAT phantom. The surface of each organ is modelled using a closed triangle mesh, and the full phantom contains 330 organs and more than 5 million triangles. A novel object-oriented geometry package, which includes an octree structure to sort the triangles, has been developed to use this complex geometry with PENELOPE. Results: As an example of the capabilities of the new code, projection images of the human pelvis region were simulated. Radioactive seeds were included inside the phantom’s prostate. Therefore, the resulting simulated images resemble what would be obtained in a clinical procedure to assess the positioning of the seeds in a prostate brachytherapy treatment. Conclusions: The new code can produce projection images of the human body that are comparable to those obtained by a real imaging system (within the limitations of the anatomical phantom and the detector model). The simulated images can be used to study and optimise an imaging task (i.e., maximise the object detectability, minimise the delivered dose, find the optimum beam energy, etc.). Since PENELOPE can simulate radiation from 50eV to 1GeV, the code can also be used to simulate radiotherapy treatments and portal imaging. Using the octree data structure, the new geometry model does not significantly increase the computing time when compared to the simulation of a much simpler quadric geometry. In conclusion, we have shown that it is feasible to use PENELOPE and a complex triangle mesh geometry to simulate real medical physics applications. [Copyright &y& Elsevier]
AB - Copyright of Radiotherapy & Oncology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIATION
KW - MONTE Carlo method
KW - PROSTATE
KW - RADIOTHERAPY
KW - Computer-aided design
KW - Monte Carlo
KW - NCAT
KW - PENELOPE
KW - penMesh
KW - Triangle mesh
N1 - Accession Number: 28610150; Badal, Andreu 1,2; Email Address: andreu.badal@upc.edu Kyprianou, Iacovos 2 Badano, Aldo 2 Sempau, Josep 1; Affiliation: 1: Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya, Spain 2: NIBIB/CDRH Laboratory for the Assessment of Medical Imaging Systems, Food and Drug Administration, USA; Source Info: Jan2008, Vol. 86 Issue 1, p99; Subject Term: RADIATION; Subject Term: MONTE Carlo method; Subject Term: PROSTATE; Subject Term: RADIOTHERAPY; Author-Supplied Keyword: Computer-aided design; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: NCAT; Author-Supplied Keyword: PENELOPE; Author-Supplied Keyword: penMesh; Author-Supplied Keyword: Triangle mesh; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.radonc.2007.11.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Akgul, Yucel
AU - Derk, Raymond C.
AU - Meighan, Terence
AU - Rao, K. Murali Krishna
AU - Murono, Eisuke P.
T1 - The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2008/01//
VL - 25
IS - 1
M3 - Article
SP - 67
EP - 75
SN - 08906238
AB - Abstract: Exposure to the pesticide methoxychlor in rodents is linked to impaired steroid production, ovarian atrophy and reduced fertility. Following in vivo administration, it is rapidly converted by the liver to 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), the reported active metabolite. Both methoxychlor and HPTE have weak estrogenic and antiandrogenic activities, and these effects are thought to be mediated through the estrogen and androgen receptors, respectively. Previous in vivo studies on methoxychlor exposure to female animals have demonstrated decreased progesterone production but no change in serum estrogen levels. We recently showed that HPTE specifically inhibits the P450 cholesterol side-chain cleavage (P450scc, CYP11A1) step resulting in decreased androgen production by cultured rat testicular Leydig cells. The current studies examined the mechanism of action of HPTE on progesterone production by cultured ovarian cells (granulosa and theca-interstitial) from pregnant mare serum gonadotropin-primed immature rats. In addition, we evaluated whether the effects of HPTE on rat ovarian cell progesterone biosynthesis were mediated through the estrogen or androgen receptors. Exposure to HPTE (0, 10, 50 or 100nM) alone progressively inhibited progesterone formation in cultured theca-interstitial and granulosa cells and the P450scc catalytic activity in theca-interstitial cells in a dose-dependent manner with significant declines starting at 50nM. However, HPTE did not change mRNA levels of the P450scc system (P450scc, adrenodoxin reductase and adrenodoxin) as well as P450scc protein levels. Of interest, estradiol, xenoestrogens (bisphenol-A or 4-tert-octylphenol), a pure antiestrogen (ICI 182,780), or antiandrogens (4-hydroxyflutamide or the vinclozolin metabolite M-2), had no effect on progesterone production even at 1000nM. Co-treatment of HPTE with ICI 182,780 did not block the effect of HPTE on progesterone formation. These studies suggest that the decline in progesterone formation following exposure to HPTE in cultured ovarian cells is associated with the inhibition of catalytic activity of P450scc at least in theca-interstitial cells. This action does not appear to be mediated through the estrogen or androgen receptor signaling pathways, and other chemicals exhibiting estrogenic, antiestrogenic or antiandrogenic properties do not mimic its effect on ovarian steroid production. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - OVARIES
KW - MESSENGER RNA
KW - CHOLESTEROL
KW - Cholesterol side-chain cleavage
KW - Granulosa cells
KW - HPTE
KW - Methoxychlor
KW - Ovarian steroidogenesis
KW - P450scc
KW - Theca cells
N1 - Accession Number: 28118445; Akgul, Yucel 1; Email Address: yakgul@hsc.wvu.edu Derk, Raymond C. 2 Meighan, Terence 2 Rao, K. Murali Krishna 2 Murono, Eisuke P. 1,2; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, M/S L-2015, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA; Source Info: Jan2008, Vol. 25 Issue 1, p67; Subject Term: METABOLITES; Subject Term: OVARIES; Subject Term: MESSENGER RNA; Subject Term: CHOLESTEROL; Author-Supplied Keyword: Cholesterol side-chain cleavage; Author-Supplied Keyword: Granulosa cells; Author-Supplied Keyword: HPTE; Author-Supplied Keyword: Methoxychlor; Author-Supplied Keyword: Ovarian steroidogenesis; Author-Supplied Keyword: P450scc; Author-Supplied Keyword: Theca cells; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.reprotox.2007.10.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mingjie Zhang
AU - Qingsheng Huang
AU - Yong Huang
AU - Wood, Owen
AU - Weishi Yuan
AU - Chancey, Caren
AU - Daniel, Sylvester
AU - Rios, Maria
AU - Hewlett, Indira
AU - Clouse, Kathleen A.
AU - Dayton, Andrew I.
T1 - beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL.
JO - Retrovirology
JF - Retrovirology
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 8
PB - BioMed Central
SN - 17424690
AB - Background: Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone β-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T). Results: Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. β-estradiol resulted in a modest inhibition of HIV-1 replication of ~26%. However, 2 nM β-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). β-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion. Conclusion: β-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status. [ABSTRACT FROM AUTHOR]
AB - Copyright of Retrovirology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTRADIOL
KW - DRUGS -- Effectiveness
KW - ANTIRETROVIRAL agents
KW - LEUCOCYTES
KW - VIRUS inactivation
KW - VIRAL replication
N1 - Accession Number: 35704900; Mingjie Zhang 1; Email Address: ming.zhang@fda.hhs.gov Qingsheng Huang 1; Email Address: qingsheng.huang@fda.hhs.gov Yong Huang 1; Email Address: yong.huang@fda.hhs.gov Wood, Owen 1; Email Address: owen.wood@fda.hhs.gov Weishi Yuan 1; Email Address: vivian.yuan@fda.hhs.gov Chancey, Caren 1; Email Address: caren.chancey@fda.hhs.gov Daniel, Sylvester 1; Email Address: sylvester.daniel@fda.hhs.gov Rios, Maria 1; Email Address: maria.rios@fda.hhs.gov Hewlett, Indira 1; Email Address: indira.hewlett@fda.hhs.gov Clouse, Kathleen A. 2; Email Address: kathleen.clouse@fda.hhs.gov Dayton, Andrew I. 1; Email Address: andrew.dayton@fda.hhs.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA 2: Center for Drug Eveluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA; Source Info: 2008, Vol. 5, Special section p1; Subject Term: ESTRADIOL; Subject Term: DRUGS -- Effectiveness; Subject Term: ANTIRETROVIRAL agents; Subject Term: LEUCOCYTES; Subject Term: VIRUS inactivation; Subject Term: VIRAL replication; Number of Pages: 8p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1186/1742-4690-5-82
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Klevens, R. Monina
AU - Edwards, Jonathan R.
AU - Andrus, Mary L.
AU - Peterson, Kelly D.
AU - Dudeck, Margaret A.
AU - Horan, Teresa C.
T1 - Dialysis Surveillance Report: National Healthcare Safety Network (NHSN)—Data Summary for 2006.
JO - Seminars in Dialysis
JF - Seminars in Dialysis
Y1 - 2008/01//Jan/Feb2008
VL - 21
IS - 1
M3 - Article
SP - 24
EP - 28
PB - Wiley-Blackwell
SN - 08940959
AB - Thirty-two outpatient hemodialysis providers in the United States voluntarily reported 3699 adverse events to the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) during 2006. These providers were previously enrolled in the Dialysis Surveillance Network. The pooled mean rates of hospitalization among patients with arteriovenous fistulas, grafts, permanent and temporary central venous catheters were 7.7, 9.2, 15.7, and 34.7 per 100 patient-months, respectively. For bloodstream infection the pooled mean rates were 0.5, 0.9, 4.2, and 27.1 per 100 patient-months in these groups. Among the 599 isolates reported, 461 (77%) represented access-associated blood stream infections in patients with central lines, and 138 (23%) were in patients with fistulas or grafts. The microorganisms most frequently identified were common skin contaminants (e.g., coagulase-negative staphylococci). In 2007, enrollment in NHSN opened to all providers of outpatient hemodialysis. Specific information is available at . [ABSTRACT FROM AUTHOR]
AB - Copyright of Seminars in Dialysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODIALYSIS
KW - ARTERIOVENOUS fistula
KW - INTRAVENOUS catheterization
KW - FILTRATION of blood
KW - BLOOD-vessels -- Abnormalities
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 28680258; Klevens, R. Monina 1; Email Address: rmk2@cdc.gov Edwards, Jonathan R. 1 Andrus, Mary L. 1 Peterson, Kelly D. 1 Dudeck, Margaret A. 1 Horan, Teresa C. 1; Affiliation: 1: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia; Source Info: Jan/Feb2008, Vol. 21 Issue 1, p24; Subject Term: HEMODIALYSIS; Subject Term: ARTERIOVENOUS fistula; Subject Term: INTRAVENOUS catheterization; Subject Term: FILTRATION of blood; Subject Term: BLOOD-vessels -- Abnormalities; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1525-139X.2007.00379.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28680258&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fisher, Gordon M.
AD - US Department of Health and Human Services
T1 - Remembering Mollie Orshansky--The Developer of the Poverty Thresholds
JO - Social Security Bulletin
JF - Social Security Bulletin
Y1 - 2008///
VL - 68
IS - 3
SP - 79
EP - 83
SN - 00377910
N1 - Accession Number: 1098131; Named Person: Orshansly, Mollie; Publication Type: Journal Article; Update Code: 201004
N2 - In a federal government career that lasted more than four decades, Mollie Orshansky worked for the Children's Bureau, the Department of Agriculture, the Social Security Administration, and other agencies. While working at the Social Security Administration during the 1960s, she developed the poverty thresholds that became the federal government's official statistical measure of poverty; her thresholds remain a major feature of the architecture of American social policy and are widely known internationally.
KW - Obituaries B32
L3 - http://www.ssa.gov/policy/docs/ssb/
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1098131&site=ehost-live&scope=site
UR - http://www.ssa.gov/policy/docs/ssb/
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Starlard-Davenport, Athena
AU - Lyn-Cook, Beverly
AU - Radominska-Pandya, Anna
T1 - Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene
JO - Steroids
JF - Steroids
Y1 - 2008/01//
VL - 73
IS - 1
M3 - Article
SP - 139
EP - 147
SN - 0039128X
AB - Abstract: Recently, we have shown that UGT1A10 is actively involved in the inactivation of E1, E2, and their 2- and 4-hydroxylated derivatives. In the present study, we show for the first time that treatment of the MCF-7 ER-positive breast cancer cell line with E2 produces a dose-dependent up-regulation of UGT1A10 mRNA levels, followed by a steady down-regulation. In contrast, E2 did not stimulate mRNA expression in the MDA-MB-231 (ER)-negative breast cancer cell line. Expression of UGT1A10 mRNA was blocked by the antiestrogen, ICI 182,780, but not by the transcriptional inhibitor, actinomycin-d. These findings suggest that regulation of UGT1A10 mRNA might be a primary transcriptional response mediated through the ER. Expression of UGT1A10 mRNA was also stimulated by other estrogenic compounds including propylpyrazoletriol (PPT) and genistein (Gen). Exposure of MCF-7 cells to 0.1nM E2 up-regulated, and then down-regulated, UGT1A protein and enzymatic activity toward E2 at 10nM E2 as determined by Western blot and glucuronidation activity assays. Collectively, these results suggest that induction of UGT1A10 mRNA expression by E2 might be mediated through ER, and that this isoform is a novel, estrogen-regulated target gene in MCF-7, ER-positive human breast cancer cells. The finding of E2-induced expression of UGT1A10 mRNA, followed by the down-regulation of UGT1A10 at pharmacological concentrations of E2, might have a significant moderating effect on E2 availability for ER and estrogen clearance, thereby promoting the signaling of E2 in breast cancer cells. [Copyright &y& Elsevier]
AB - Copyright of Steroids is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCURONOSYLTRANSFERASE
KW - ESTROGEN
KW - BREAST cancer
KW - CANCER cells
KW - Breast cancer
KW - Estradiol (E2)
KW - Estrogen receptor (ER)
KW - UDP-glucuronosyltransferase ( UGT )
KW - UGT1A10
KW - UGTs
N1 - Accession Number: 27941702; Starlard-Davenport, Athena 1 Lyn-Cook, Beverly 2 Radominska-Pandya, Anna 1; Email Address: radominskaanna@uams.edu; Affiliation: 1: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W. Markham, Slot 516, Little Rock, AR 72205, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, HFT-100, Jefferson, AR 72079, USA; Source Info: Jan2008, Vol. 73 Issue 1, p139; Subject Term: GLUCURONOSYLTRANSFERASE; Subject Term: ESTROGEN; Subject Term: BREAST cancer; Subject Term: CANCER cells; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: Estradiol (E2); Author-Supplied Keyword: Estrogen receptor (ER); Author-Supplied Keyword: UDP-glucuronosyltransferase ( UGT ); Author-Supplied Keyword: UGT1A10; Author-Supplied Keyword: UGTs; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.steroids.2007.09.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27941702&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-11975-001
AN - 2008-11975-001
AU - Stroul, Beth A.
AU - Blau, Gary M.
AU - Sondheimer, Diane L.
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Systems of care: A strategy to transform children's mental health care.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 3
EP - 23
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Stroul, Beth A., Management & Training Innovations, Inc., 7417 Seneca Ridge Drive, Suite 100, McLean, VA, US, 22102
N1 - Accession Number: 2008-11975-001. Partial author list: First Author & Affiliation: Stroul, Beth A.; Management & Training Innovations, Inc., McLean, VA, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Government Programs; Health Care Delivery; Mental Health Services; Health Care Reform. Minor Descriptor: Adolescent Psychology; Affective Disorders; At Risk Populations; Child Psychology; Community Mental Health Services; Family; Government; Philosophies. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - The need to reform children's mental health systems in the United States has been extensively documented. As early as 1969, the Joint Commission on Mental Health of Children concluded that only a fraction of the children in need were actually receiving mental health services and that the services being provided were largely ineffective. These initial reports served as a catalyst for bringing the federal government's attention to the issue of children's mental health. The first federal program, the Child and Adolescent Service System Program (CASSP), was launched by the National Institute of Mental Health in 1984 to assist states and communities in building the capacity to develop services targeted for children with serious emotional disturbances (SEDs) and their families. Such systems of care emphasize a wide array of services, individualized care, the least restrictive environments possible for service provision, the full participation of families and youth, coordination among child-serving agencies and programs, and cultural and linguistic competence. This chapter defines and clarifies the system of care concept and philosophy, which has been used as the foundation for system reform for more than two decades. System of care development is explained as a complex, multilevel process with goals and outcomes at various levels of intervention. Systems of care are discussed as a strategy for transforming the approach to mental health care for children and their families. The chapter also provides an overview of federal programs supporting the development of systems of care for children with or at risk for emotional disorders and their families, highlighting the current Comprehensive Community Mental Health Services for Children and Their Families Program (i.e., the Children's Mental Health Initiative). Information is presented about the types of supports that have been provided by federal and state governments to assist in developing and sustaining systems of care (e.g., training and technical assistance, evaluation, social marketing). Finally, the chapter discusses the future directions of systems of care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child & adolescent mental health
KW - mental health care
KW - systems of care
KW - health care reform
KW - federal programs
KW - at risk children
KW - emotional disorders
KW - 2008
KW - Government Programs
KW - Health Care Delivery
KW - Mental Health Services
KW - Health Care Reform
KW - Adolescent Psychology
KW - Affective Disorders
KW - At Risk Populations
KW - Child Psychology
KW - Community Mental Health Services
KW - Family
KW - Government
KW - Philosophies
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-002
AN - 2008-11975-002
AU - Manteuffel, Brigitte
AU - Stephens, Robert L.
AU - Brashears, Freda
AU - Krivelyova, Anna
AU - Fisher, Sylvia Kay
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Evaluation results and systems of care: A review.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 25
EP - 69
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Manteuffel, Brigitte, Applied Research Division, Macro International, Inc., 3 Corporate Square, Suite 370, Atlanta, GA, US, 30329
N1 - Accession Number: 2008-11975-002. Partial author list: First Author & Affiliation: Manteuffel, Brigitte; Applied Research Division, Macro International, Inc., Atlanta, GA, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Community Mental Health Services; Emotional Disturbances; Health Care Delivery; Mental Health Program Evaluation; Mental Health Services. Minor Descriptor: Adolescent Psychology; Child Psychology; Community Mental Health; Family; Health; Treatment Outcomes; Well Being. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). Tests & Measures: Enrollment and Demographic Information IV-V Form; Caregiver Information Questionnaire; youth Information Questionnaire; Child and Adolescent Functional Assessment Scale; Reynolds Childhood Manifest Anxiety Scale; Vineland Screener; Restrictiveness of Living Environments; Living Situations Questionnaire; Education Questionnaire; Delinquency Survey; Substance Use Survey; GAIN Quick-R; Family Assessment Device; Family Life Questionnaire; Behavioral and Emotional Rating Scale: A Strength-Based Approach to Assessment; Child Behavior Checklist; Caregiver Strain Questionnaire DOI: 10.1037/t13809-000; Family Resource Scale DOI: 10.1037/t33262-000; Descriptive Information Questionnaire DOI: 10.1037/t45162-000; Reynolds Adolescent Depression Scale; Youth Self-Report; Family Empowerment Scale DOI: 10.1037/t07132-000; Columbia Impairment Scale DOI: 10.1037/t06724-000. Methodology: Empirical Study. References Available: Y. Page Count: 45.
AB - Providing mental health services and supports for children and youth with serious emotional disturbance and their families in a coordinated manner across multiple service providers in systems of care requires change at multiple levels. Service system change affects agency relationships and structures, service provider practices, and the experiences and well-being of the children, youth, and families who receive services in systems of care. Evaluation of the complex characteristics, development, and outcomes of systems of care needs to address the multiple levels of system of care development and relationships among systems, service delivery, and child or youth and family outcomes. This chapter provides a review of the results of research and evaluation regarding systems of care. Beginning with a review of previous research, the chapter focuses on the results of the national evaluation implemented in communities funded by the federal Comprehensive Community Mental Health Services for Children and Their Families Program to implement systems of care. Conducted since 1993 with more than 81,000 children and youth from 126 communities funded since the inception of this program, the national evaluation represents the largest effort to date to understand the characteristics and outcomes of efforts to serve children and youth with serious mental health needs and their families through a system of care approach. The characteristics of children, adolescents, and families receiving services in systems of care are briefly reviewed. Results are highlighted at the various levels of system of care development—the system level, the service delivery level, the practice level, and the child and family level. Factors related to improved outcomes are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - emotional disturbances
KW - children
KW - adolescents
KW - systems of care
KW - systems evaluation
KW - service delivery
KW - treatment outcomes
KW - 2008
KW - Community Mental Health Services
KW - Emotional Disturbances
KW - Health Care Delivery
KW - Mental Health Program Evaluation
KW - Mental Health Services
KW - Adolescent Psychology
KW - Child Psychology
KW - Community Mental Health
KW - Family
KW - Health
KW - Treatment Outcomes
KW - Well Being
KW - 2008
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: 280-97-8014; 280-00-8040; 280-99-8023; 280-03-1603; 280-03-1604. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-002&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-014
AN - 2008-11975-014
AU - Rodriguez, Maria J.
AU - Rubenstein, Lisa
AU - Huff, Barbara
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Social marketing.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 381
EP - 398
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Rodriguez, Maria J., Vanguard Communications, 2121 K Street NW, Suite 300, Washington, DC, US, 20037
N1 - Accession Number: 2008-11975-014. Partial author list: First Author & Affiliation: Rodriguez, Maria J.; Vanguard Communications, Washington, DC, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Health Care Delivery; Mental Health Services; Social Marketing. Minor Descriptor: Behavior Change; Communities; Family; Initiative; Marketing; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 18.
AB - As early as 1951, experts were exploring the use of commercial marketing practices to sell social causes and behavior change. By the mid 1990's, social marketing techniques had proven their worth. Americans were smoking less, designating drivers, and preventing forest fires. Given the success of social marketing in other areas, the U.S. Congress recognized the important role it could play in overcoming stigma when it mandated investment in the design of systems of care for children, youth, and their families. In 1992, when federal funding became available to develop systems of care across the country and in tribal nations, the government included a social marketing component—the Caring for Every Child's Mental Health Campaign. Since then, the campaign has undertaken national social marketing efforts and provided technical assistance in social marketing to federally funded system of care communities. Specifically, the campaign has helped system of care communities design and implement social marketing initiatives that have led to increased access to care by all children and youth with serious mental health needs and their families. In addition, the campaign has produced public information materials that systems of care use to educate children, youth, families, and their system partners on children's mental health issues. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavior change
KW - social marketing initiatives
KW - systems of care
KW - mental health needs
KW - communities
KW - children
KW - youth & families
KW - 2008
KW - Health Care Delivery
KW - Mental Health Services
KW - Social Marketing
KW - Behavior Change
KW - Communities
KW - Family
KW - Initiative
KW - Marketing
KW - Mental Health
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-014&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-018
AN - 2008-11975-018
AU - Clark, Hewitt B.
AU - Deschênes, Nicole
AU - Sieler, DeDe
AU - Green, Melanie E.
AU - White, Gwendolyn
AU - Sondheimer, Diane L.
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Services for youth in transition to adulthood in systems of care.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 517
EP - 543
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Clark, Hewitt B., Department of Child and Family Studies, Louis de la Parte Florida Mental Health Institute, University of South Florida, 13301 Bruce B. Downs Boulevard, Tampa, FL, US, 33612
N1 - Accession Number: 2008-11975-018. Partial author list: First Author & Affiliation: Clark, Hewitt B.; Department of Child and Family Studies, Louis de la Parte Florida Mental Health Institute, University of South Florida, Tampa, FL, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Adolescent Development; Community Mental Health Services; Emotional Disturbances; Health Care Delivery; Mental Disorders. Minor Descriptor: Disabilities; Evaluation; Initiative; Life Changes; Self-Care Skills. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 27.
AB - Young adults experience dramatic changes across all areas of development during their transition to adulthood. Young people's decisions, choices, and associated experiences set a foundation for their transition to future adult roles in the domains of employment, education, living situation, and community-life functioning. This period of transition is especially challenging for the more than 3 million youth and young adults with serious emotional disturbances or serious mental illness (SED/SMI). This population of young people has a higher secondary school dropout rate, higher arrest and unemployment rates, and a lower independent living rate compared with their peers without disabilities. The Partnerships for Youth Transition (PYT) initiative provided an opportunity for the establishment of five demonstration community sites to examine ways to improve the outcomes of transition-age youth with SED/SMI. This chapter highlights the development, implementation, and preliminary evaluation of the transition systems developed by the PYT sites. Specifically, this chapter provides: 1) an overview of the PYT initiative and delineation of the age-appropriate interventions and support services that were common across the majority of the sites; 2) an overview of the Transition to Independence Process (TIP) model framework, including an outline of the transition domains of employment and career, education, living situations, and community-life functioning; 3) brief descriptions of the community transition systems implemented at the five PYT sites, with particular attention to the involvement of youth, family, and local and state partners; 4) preliminary PYT evaluation outcome findings; and 5) lessons learned at the practice, system, and policy levels. Thus, this chapter is designed to provide the reader with promising practices and lessons learned related to planning, implementing, and sustaining community transition systems for youth and young adults with SED/SMI and their families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - systems of care
KW - young adults with serious emotional disturbances
KW - mental illness
KW - Partnerships for Youth Transition
KW - community transition systems
KW - 2008
KW - Adolescent Development
KW - Community Mental Health Services
KW - Emotional Disturbances
KW - Health Care Delivery
KW - Mental Disorders
KW - Disabilities
KW - Evaluation
KW - Initiative
KW - Life Changes
KW - Self-Care Skills
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-022
AN - 2008-11975-022
AU - Isaacs, Mareasa R.
AU - Huang, Larke Nahme
AU - Hernandez, Mario
AU - Echo-Hawk, Holly
AU - Acevedo-Polakovich, Ignacio David
AU - Martinez, Ken
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Services for youth and their families in culturally diverse communities.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 619
EP - 639
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Isaacs, Mareasa R., National Alliance of Multi-Ethnic Behavioral Health Associations (NAMBHA), 1220 Blair Mill Road, Suite 404, Silver Spring, MD, US, 20910
N1 - Accession Number: 2008-11975-022. Partial author list: First Author & Affiliation: Isaacs, Mareasa R.; National Alliance of Multi-Ethnic Behavioral Health Associations (NAMBHA), Silver Spring, MD, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Communities; Diversity; Mental Health Services; Sociocultural Factors. Minor Descriptor: Cross Cultural Differences; Cultural Sensitivity; Health Care Delivery; Mental Health; Multiculturalism. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - Culture provides an interpretive guide for most human behavior. The influence of culture on mental health is widely recognized. It should not be surprising to learn that a substantial body of research examining mental health services in the United States finds significant and meaningful ethnicity-based and race-based disparities in the availability of, access to meaningful mental health care. This chapter provides an orientation to some of the most important issues involved in transforming mental health systems so that they are responsive to the cultural needs and social contexts of local communities. It is guided by the premise that cultural competence in mental health services occurs only when there is congruence among: 1) the direct service practices available to a community; 2) the policies, structures, and processes of the organizations supporting these direct services, and 3) a community's culture and social context. Accordingly, both direct service practices and organizational support are discussed with respect to issues involved in ensuring that both of these domains of systems of care foster congruence with a local community's culture and social context. Examples from the field are used to illustrate culturally competent approaches, and recommendations are offered for improving services to culturally diverse communities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health services
KW - culturally diverse communities
KW - cultural competence
KW - 2008
KW - Communities
KW - Diversity
KW - Mental Health Services
KW - Sociocultural Factors
KW - Cross Cultural Differences
KW - Cultural Sensitivity
KW - Health Care Delivery
KW - Mental Health
KW - Multiculturalism
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-022&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-023
AN - 2008-11975-023
AU - Dodge, Joan M.
AU - Huang, Larke Nahme
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Workforce implications: Issues and strategies for workforce development.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 643
EP - 662
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Dodge, Joan M., Senior Policy Associate, National Technical Assistance Center for Children's Mental Health, Georgetown University Center for Child and Human Development, 3300 Whitehaven Street NW, Suite 3300, Washington, DC, US, 20007
N1 - Accession Number: 2008-11975-023. Partial author list: First Author & Affiliation: Dodge, Joan M.; National Technical Assistance Center for Children's Mental Health, Georgetown University Center for Child and Human Development, Washington, DC, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Family; Health Care Delivery; Mental Health; Mental Health Personnel; Mental Health Services. Minor Descriptor: Child Psychology; Clinical Methods Training; Community Mental Health Training. Classification: Professional Education & Training (3410); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 20.
AB - The workforce stands at the heart of transforming mental health delivery systems for children and their families. Without careful attention to ensuring the presence of high-quality workers who are prepared and trained in the skills and competencies needed to work in today's environment, the task of transformation becomes difficult, if not impossible. Workforce development is a necessary and critical strategy for transformation. For many years, state and local agencies, community organizations, and professional associations across the United States have faced major challenges in educating, training, and retaining a quality mental health workforce. Workforce development concerns are evident within nearly every discipline and among many of the stakeholder groups that address mental health disorders in adults, children, youth, and their families. Workforce development is finally being recognized as a major lever of change in transforming the service delivery systems for those needing mental health services. Levers of change, or leverage points, are those places in a complex system where a small shift in one thing can produce cascading changes throughout the system. Workforce strategies, including effective recruitment, retention, and training practices, must be seen as levers of change in transforming systems of care. Nationwide, many innovative efforts are addressing workforce challenges occurring at community, state, and national levels. These comprise multipronged efforts by stakeholders to address the mental health workforce crisis. This chapter outlines unique issues and challenges for the health and human service delivery workforce in the children's mental health field. It also describes workforce development goals and some of the creative responses implemented by individuals, organizations, and agencies to ensure that a quality workforce is in place for children and youth and their families. In addition, the chapter outlines four key transformation strategies that are significant levers of change to advance workforce development. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health delivery systems
KW - workforce development
KW - children & families
KW - mental health personnel training
KW - 2008
KW - Family
KW - Health Care Delivery
KW - Mental Health
KW - Mental Health Personnel
KW - Mental Health Services
KW - Child Psychology
KW - Clinical Methods Training
KW - Community Mental Health Training
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-023&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-11975-024
AN - 2008-11975-024
AU - Goldman, Sybil K.
AU - Stroul, Beth A.
AU - Huang, Larke Nahme
AU - Koyanagi, Chris
ED - Stroul, Beth A.
ED - Blau, Gary M.
ED - Stroul, Beth A., (Ed)
ED - Blau, Gary M., (Ed)
T1 - Policy implications: New directions in child and adolescent mental health.
T2 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
SP - 663
EP - 688
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Goldman, Sybil K., National Technical Assistance for Children's Mental Health, Georgetown University Center for Children and Human Development, 3300 Whitehaven Street NW, Suite 3300, Washington, DC, US, 20007
N1 - Accession Number: 2008-11975-024. Partial author list: First Author & Affiliation: Goldman, Sybil K.; National Technical Assistance for Children's Mental Health, Georgetown University Center for Children and Human Development, Washington, DC, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Government Policy Making; Health Care Delivery; Mental Health Services; Public Health; Health Care Policy. Minor Descriptor: Adolescent Psychology; Child Psychology; Disabilities; Emotional Disturbances; Mental Health; Well Being. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - This chapter focuses on policy directions in child and adolescent mental health. The policy framework presented goes beyond an emphasis on children with serious emotional disturbances to a broader vision of a public health approach that aims to prevent mental health problems and create conditions that promote positive social-emotional health and well-being for children. Achieving this vision will require a transformation of policies and the current service delivery system and will involve addressing both prevention and treatment. There has been significant progress made in understanding how to build comprehensive, community-based systems of care to improve services and outcomes for children and youth with serious emotional disturbances. The challenge is to incorporate the values, principles, and lessons learned from systems of care into an overarching public health framework that promotes health, prevents disability, and treats those in need of services based on the best available science of what is effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - child & adolescent mental health
KW - public policy
KW - serious emotional disturbance
KW - public health
KW - well being
KW - prevention
KW - treatment
KW - community-based systems
KW - 2008
KW - Government Policy Making
KW - Health Care Delivery
KW - Mental Health Services
KW - Public Health
KW - Health Care Policy
KW - Adolescent Psychology
KW - Child Psychology
KW - Disabilities
KW - Emotional Disturbances
KW - Mental Health
KW - Well Being
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-024&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Ju Young Ryu
AU - Ena Lee
AU - Hee Jin Kim
AU - Hyeyoung Park
AU - Ji Young Im
AU - Jeonga Kim
AU - Soon Young Han
AU - Il Hyun Kang
AU - Kui Lea Park
AU - Hyung Sik Kim
T1 - Alterations of di(n-butyl)phthalate-induced oxidative stress in the testis of hypothyroid rats.
JO - Toxicological & Environmental Chemistry
JF - Toxicological & Environmental Chemistry
Y1 - 2008/01//
VL - 90
IS - 1
M3 - Article
SP - 113
EP - 126
SN - 02772248
AB - The aim of the present study was to investigate the effects of di(n-butyl)phthalate (DBP) on oxidative damage in the testes of hypothyroid rats. Hypothyroidism was induced by administering 0.1% 6-N-propyl-2-thiouracil (PTU) in drinking water for 30 days. DBP was dissolved in corn oil and administered daily for 30 days by oral gavage. Significant decreases in testes weight were observed both in normal (DBP) and hypothyroid (PTU + DBP) groups. Serum testosterone concentrations were significantly reduced in the DBP groups, but no significant change occurred in hypothyroid rats. Di(n-butyl)phthalate significantly increased malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG) level in the testes, whereas the DBP-induced oxidative lipid (MDA) and DNA (8-OHdG) damage were less in hypothyroid rats. PTU-induced hypothyroid rats decreased testicular catalase activity, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities did not show any significant changes. However, the DBP and PTU + DBP groups significantly increased catalase and SOD activities in testis. The testicular expression of thyroid hormone receptor α-1 (TRα-1) was significantly increased in the DBP and PTU + DBP groups. In contrast, androgen receptor (AR) protein levels were not detected in the DBP and PTU + DBP groups. Di(n-butyl)phthalate significantly increased the peroxisome proliferator-activated receptor-r (PPAR-r) and retinoid X receptor-α (RXR-α) levels. Peroxisome proliferators activated-receptors-α and RXR-r protein levels were markedly decreased in the DBP groups, but these protein levels increased in the PTU + DBP group, as compared to DBP alone. These results suggest that PTU-induced hypothyroidism may protect against oxidative damage in the testis, probably due to the regulation of the PPAR and RXR expression, which is associated with decreased metabolic activation of DBP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicological & Environmental Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical toxicology
KW - Hypothyroidism
KW - Thyroid hormones
KW - Catalase test (Microbiology)
KW - Glutathione
KW - Toxicology -- Animal models
KW - catalase
KW - DBP
KW - glutathione peroxidase
KW - PPAR
KW - SOD
KW - thyroid hormone
KW - TR
N1 - Accession Number: 33022067; Ju Young Ryu 1; Ena Lee 1; Hee Jin Kim 1; Hyeyoung Park 1; Ji Young Im 1; Jeonga Kim 1; Soon Young Han 2; Il Hyun Kang 2; Kui Lea Park 2; Hyung Sik Kim 1; Email Address: hkims@pusan.ac.kr; Affiliations: 1 : Laboratory of Molecular Toxicology, College of Pharmacy, Pusan National University, Busan, South Korea; 2 : National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea; Source Info: Jan2008, Vol. 90 Issue 1, p113; Thesaurus Term: Biochemical toxicology; Subject Term: Hypothyroidism; Subject Term: Thyroid hormones; Subject Term: Catalase test (Microbiology); Subject Term: Glutathione; Subject Term: Toxicology -- Animal models; Author-Supplied Keyword: catalase; Author-Supplied Keyword: DBP; Author-Supplied Keyword: glutathione peroxidase; Author-Supplied Keyword: PPAR; Author-Supplied Keyword: SOD; Author-Supplied Keyword: thyroid hormone; Author-Supplied Keyword: TR; Number of Pages: 14p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 7 Graphs; Document Type: Article
L3 - 10.1080/02772240701284451
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=8gh&AN=33022067&site=ehost-live&scope=site
DP - EBSCOhost
DB - 8gh
ER -
TY - JOUR
AU - Eichelberger, Maryna C.
AU - Hassantoufighi, Arash
AU - Meng Wu
AU - Min Li
T1 - Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay.
JO - Virology Journal
JF - Virology Journal
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 8
PB - BioMed Central
SN - 1743422X
AB - Background: The emergence of influenza strains that are resistant to commonly used antivirals has highlighted the need to develop new compounds that target viral gene products or host mechanisms that are essential for effective virus replication. Existing assays to identify potential antiviral compounds often use high throughput screening assays that target specific viral replication steps. To broaden the search for antivirals, cell-based replication assays can be performed, but these are often labor intensive and have limited throughput. Results: We have adapted a traditional virus neutralization assay to develop a practical, cell-based, high throughput screening assay. This assay uses viral neuraminidase (NA) as a read-out to quantify influenza replication, thereby offering an assay that is both rapid and sensitive. In addition to identification of inhibitors that target either viral or host factors, the assay allows simultaneous evaluation of drug toxicity. Antiviral activity was demonstrated for a number of known influenza inhibitors including amantadine that targets the M2 ion channel, zanamivir that targets NA, ribavirin that targets IMP dehydrogenase, and bis-indolyl maleimide that targets protein kinase A/C. Amantadine-resistant strains were identified by comparing IC50 with that of the wild-type virus. Conclusion: Antivirals with specificity for a broad range of targets are easily identified in an accelerated viral inhibition assay that uses NA as a read-out of replication. This assay is suitable for high throughput screening to identify potential antivirals or can be used to identify drug-resistant influenza strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Virology Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAMINIDASE
KW - HIGH throughput screening (Drug development)
KW - ANTIVIRAL agents
KW - INFLUENZA viruses
KW - INFLUENZA
KW - STRAIN theory (Chemistry)
KW - DRUG resistance in microorganisms
N1 - Accession Number: 38025941; Eichelberger, Maryna C. 1,2; Email Address: Maryna.Eichelberger@fda.hhs.gov Hassantoufighi, Arash 1; Email Address: Arash.Hassantoufighi@fda.hhs.gov Meng Wu 3; Email Address: meng@jhmi.edu Min Li 3; Email Address: minli@jhmi.edu; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA 2: Division of Viral Products, OVRR, CBER, FDA; 8800 Rockville Pike, Building 29A 1D24; Bethesda MD, 20892, USA 3: High Throughput Biology Center and Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Source Info: 2008, Vol. 5, Special section p1; Subject Term: NEURAMINIDASE; Subject Term: HIGH throughput screening (Drug development); Subject Term: ANTIVIRAL agents; Subject Term: INFLUENZA viruses; Subject Term: INFLUENZA; Subject Term: STRAIN theory (Chemistry); Subject Term: DRUG resistance in microorganisms; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1186/1743-422X-5-109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38025941&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Straight, Timothy M.
AU - Ottolini, Martin G.
AU - Prince, Gregory A.
AU - Eichelberger, Maryna C.
T1 - Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats.
JO - Virology Journal
JF - Virology Journal
Y1 - 2008/01//
VL - 5
M3 - Article
SP - 1
EP - 9
PB - BioMed Central
SN - 1743422X
AB - Background: Influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins, which results in immunity against influenza A viruses of the same HA and NA subtype. A heterosubtypic immune response that offers some protection against different influenza A subtypes has been suggested from epidemiologic studies in human influenza outbreaks, and has been induced in experimental animal models. Original studies of such cross-protection showed that cytotoxic T lymphocytes (CTL) protect H3N2-immune mice from a lethal H1N1 infection. More recent studies in mice demonstrate that antibodies also contribute to heterosubtypic immunity (HSI). We previously demonstrated that HSI in cotton rats (Sigmodon hispidus) is characterized by protection of H3N2- immune animals from influenza H1N1-induced increase in respiratory rate (tachypnea). Alternatively, H1N1-immune animals are protected from H3N2-induced tachypnea. The experiments described in this report were designed to elucidate the immune mechanism that prevents this very early sign of disease. Results: Our results show that cotton rats provided with H1N1-immune serum prior to challenge with an H3N2 virus were protected from influenza-associated tachypnea, with the degree of protection correlating with the antibody titer transferred. Immunization with an inactivated preparation of virus delivered intramuscularly also provided some protection suggesting that CTL and/or mucosal antibody responses are not required for protection. Antibodies specific for conserved epitopes present on the virus exterior are likely to facilitate this protection since prophylactic treatment of cotton rats with anti-M2e (the extracellular domain of M2) but not antinucleoprotein (NP) reduced virus-induced tachypnea. Conclusion: In the cotton rat model of heterosubtypic immunity, humoral immunity plays a role in protecting animals from influenza-induced tachypea. Partial protection against respiratory disease caused by different influenza A subtypes can be attained with either live virus administered intranasally or inactivated virus delivered intramuscularly suggesting that either vaccine regimen may provide some protection against potential pandemic outbreaks in humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Virology Journal is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA A virus
KW - HEMAGGLUTININ
KW - NEURAMINIDASE
KW - GLYCOPROTEINS
KW - IMMUNE response
KW - T cells
KW - COTTON rats as laboratory animals
N1 - Accession Number: 38025982; Straight, Timothy M. 1,2; Email Address: Timothy.Straight@amedd.army.mil Ottolini, Martin G. 3; Email Address: mottolini@usuhs.mil Prince, Gregory A. 4; Email Address: gprince@erols.com Eichelberger, Maryna C. 5; Email Address: Maryna.Eichelberger@fda.hhs.gov; Affiliation: 1: Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX, USA 2: Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 3: Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA 4: Virion Systems Inc., Rockville, MD, USA 5: CBER, Food and Drug Administration, Bethesda, MD, USA; Source Info: 2008, Vol. 5, Special section p1; Subject Term: INFLUENZA A virus; Subject Term: HEMAGGLUTININ; Subject Term: NEURAMINIDASE; Subject Term: GLYCOPROTEINS; Subject Term: IMMUNE response; Subject Term: T cells; Subject Term: COTTON rats as laboratory animals; Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1186/1743-422X-5-44
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38025982&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2008-12886-017
AN - 2008-12886-017
AU - Meyerhoefer, Chad D.
ED - Smith, Alan L.
ED - Biddle, Stuart J. H.
ED - Smith, Alan L., (Ed)
ED - Biddle, Stuart J. H., (Ed)
T1 - Economic principles.
T2 - Youth physical activity and sedentary behavior: Challenges and solutions.
Y1 - 2008///
SP - 429
EP - 451
CY - Champaign, IL, US
PB - Human Kinetics
SN - 0-7360-6509-1
SN - 978-0-7360-6509-2
N1 - Accession Number: 2008-12886-017. Partial author list: First Author & Affiliation: Meyerhoefer, Chad D.; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20090928. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-7360-6509-1, Hardcover; 978-0-7360-6509-2, Hardcover. Language: English. Major Descriptor: Economics; Government Policy Making; Physical Activity; Welfare Services (Government). Classification: Promotion & Maintenance of Health & Wellness (3365); Social Processes & Social Issues (2900). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23.
AB - Like many other academic disciplines, economics has a long history with a rich theoretical basis and many analytical and empirical findings. A thorough discussion of the theoretical axioms and mathematical constructs underlying the economic principles of physical activity is beyond the scope of this chapter. Instead, I present a general economic framework of individual physical activity participation decisions and describe their place in the context of the broader economy. Under ideal conditions, the unconstrained behavior of self-interested individuals has some very desirable implications for social welfare. However, departures from these conditions result in cases in which governments and other institutions can improve economic efficiency through their ability to influence people's opportunities to engage in physical activity. Consequently the economic justification and analysis of public policies related to youth physical activity are taken up in the second part of the chapter. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - economics
KW - physical activity
KW - social welfare
KW - public policies
KW - 2008
KW - Economics
KW - Government Policy Making
KW - Physical Activity
KW - Welfare Services (Government)
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12886-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19055-004
AN - 2007-19055-004
AU - Clark, H. Westley
AU - Power, A. Kathryn
AU - Le Fauve, Charlene E.
AU - Lopez, Elizabeth I.
T1 - Policy and practice implications of epidemiological surveys on co-occurring mental and substance use disorders.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2008/01//
VL - 34
IS - 1
SP - 3
EP - 13
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Clark, H. Westley, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2007-19055-004. PMID: 17574794 Partial author list: First Author & Affiliation: Clark, H. Westley; Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20080107. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Epidemiology; Mental Disorders; Policy Making. Minor Descriptor: Evidence Based Practice; Public Health; Social Services; Substance Use Disorder. Classification: Psychological & Physical Disorders (3200). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Jan, 2008.
AB - This article describes factors that influence national policy and practice, with particular focus on the implications of epidemiological survey research. Examples of areas of concern to policymakers include treatment-seeking patterns, access to care at points of service in public health and social service systems, evidence-based practices, workforce development, and the complexities of reimbursement. In responding to data on systemic barriers to care, the Substance Abuse and Mental Health Services Administration (SAMHSA) has sought to promote a no wrong door strategy to address the needs of persons with co-occurring disorders (CODs) involving their mental health and substance use. Examples of SAMHSA programs and policies addressing CODs discussed in this article include targeted partnerships with the states, mechanisms to enhance system infrastructure, technical assistance, and initiatives with special populations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - policy
KW - epidemiological surveys
KW - co-occurring mental disorders
KW - substance use
KW - public health
KW - social services systems
KW - evidence-based practice
KW - 2008
KW - Comorbidity
KW - Drug Abuse
KW - Epidemiology
KW - Mental Disorders
KW - Policy Making
KW - Evidence Based Practice
KW - Public Health
KW - Social Services
KW - Substance Use Disorder
KW - 2008
DO - 10.1016/j.jsat.2006.12.032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19055-004&site=ehost-live&scope=site
UR - westley.clark@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2007-19488-002
AN - 2007-19488-002
AU - Lathers, Claire M.
AU - Schraeder, Paul L.
AU - Bungo, Michael W.
T1 - The mystery of sudden death: Mechanisms for risks.
JF - Epilepsy & Behavior
JO - Epilepsy & Behavior
JA - Epilepsy Behav
Y1 - 2008/01//
VL - 12
IS - 1
SP - 3
EP - 24
CY - Netherlands
PB - Elsevier Science
SN - 1525-5050
AD - Lathers, Claire M., 115 South Manning Boulevard, Albany, NY, US, 12203
N1 - Accession Number: 2007-19488-002. PMID: 18086454 Partial author list: First Author & Affiliation: Lathers, Claire M.; Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20080114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Epilepsy; Heart Disorders; Risk Factors. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 22. Issue Publication Date: Jan, 2008.
AB - This review addresses the possible overlapping mechanisms that may apply to the risk of sudden unexpected death occurring in epilepsy and in cardiac disease. It explores the interaction between the central and peripheral autonomic nervous systems and the cardiopulmonary systems. Included is a discussion of the potential interactive role of genetically determined subtle cardiac risk factors for arrhythmias with a predisposition for seizure-related cardiac arrhythmias. We address the possible mechanisms that are operant in producing both epileptogenic and cardiogenic arrhythmias. Finally, we speculate about potential preventive measures to minimize the risk of both sudden unexpected death in epilepsy and sudden cardiac death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epilepsy
KW - sudden death
KW - risk factors
KW - cardiac diseases
KW - 2008
KW - Death and Dying
KW - Epilepsy
KW - Heart Disorders
KW - Risk Factors
KW - 2008
DO - 10.1016/j.yebeh.2007.09.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-19488-002&site=ehost-live&scope=site
UR - Lathers@attglobal.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2014-14547-003
AN - 2014-14547-003
AU - Giannini, Margaret
T1 - Office on disability, U.S. Department of health and human services.
JF - Disability and Health Journal
JO - Disability and Health Journal
JA - Disabil Health J
Y1 - 2008/01//
VL - 1
IS - 1
SP - 5
EP - 6
CY - Netherlands
PB - Elsevier Science
SN - 1936-6574
SN - 1876-7583
AD - Giannini, Margaret
N1 - Accession Number: 2014-14547-003. PMID: 21122705 Partial author list: First Author & Affiliation: Giannini, Margaret; U.S. Department of Health and Human Services, DC, US. Release Date: 20140609. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Assistive Technology; Disabilities; Health; Health Care Services; Human Services. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Health & Mental Health Services (3370). Population: Human (10). Location: US. Page Count: 2. Issue Publication Date: Jan, 2008. Copyright Statement: All rights reserved. Elsevier Inc. 2008.
AB - Presents a paper from the director of the Office on Disability, U.S. Department of Health and Human Services. The United States is home to approximately 54 million persons with disabilities of all ages and races. Yet even with the enormous strides that have been made in legislation, assistive technology, and cultural attitudes in the past century, many barriers remain to full community participation for those 54 million people. Health is so integrally related to each of these domains that the U.S. Department of Health and Human Services Office on Disability initiated the issuance of the Surgeon General's Call to Action to Improve the Health and Wellness of Persons with Disabilities in 2005. This seminal document reviews the most advanced scientific research on the state of health of persons with disabilities in the United States, as well as barriers to maintaining good health and accessing health care. The Call to Action is having a growing impact as a national effort to improve the health and wellness of persons with disabilities. This crescendo of awareness and action depends on the broad foundation of partners that see the importance of the issues identified in the Call to Action and invest themselves in achieving its goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - persons with disabilities
KW - health
KW - human services
KW - assistive technology
KW - health care
KW - 2008
KW - Assistive Technology
KW - Disabilities
KW - Health
KW - Health Care Services
KW - Human Services
KW - 2008
DO - 10.1016/j.dhjo.2007.10.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-14547-003&site=ehost-live&scope=site
UR - margaret.giannini@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-10407-012
AN - 2008-10407-012
AU - Dilonardo, Joan
AU - Coffey, Rosanna
AU - Vandivort-Warren, Rita
AU - Buck, Jeffrey
T1 - Datapoints: Inpatient utilization for persons with co-occurring disorders.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/01//
VL - 59
IS - 1
SP - 14
EP - 14
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Dilonardo, Joan, 19104 Olney Mill Rd., Olney, MD, US, 20832
N1 - Accession Number: 2008-10407-012. PMID: 18182531 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Dilonardo, Joan; Thomson Healthcare, Washington,, DC, US. Release Date: 20080908. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Health Care Utilization; Hospitalization; Mental Disorders. Minor Descriptor: Medicaid; Mental Health Services; Substance Use Disorder. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 1. Issue Publication Date: Jan, 2008.
AB - People with co-occurring mental and substance use disorders have been shown to be frequent users of inpatient care. This column describes use of inpatient care in Delaware, Oklahoma, and Washington by clients who received at least one mental health or substance abuse service from the state mental health, substance abuse, or Medicaid agency in calendar year 1997. Results were expected to differ across states because of potential differences in the case mix of patients served, types and amounts of services supported, regional variation in clinical practice, population dispersion and density, organization of each state authority administering services, managed care involvement, total dollars devoted to such services, and other factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - co-occurring disorders
KW - substance use disorders
KW - mental disorders
KW - Medicaid
KW - inpatient utilization
KW - 2008
KW - Comorbidity
KW - Drug Abuse
KW - Health Care Utilization
KW - Hospitalization
KW - Mental Disorders
KW - Medicaid
KW - Mental Health Services
KW - Substance Use Disorder
KW - 2008
DO - 10.1176/appi.ps.59.1.14
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10407-012&site=ehost-live&scope=site
UR - dilondoty@verizon.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00348-005
AN - 2008-00348-005
AU - Petersen, Martin R.
AU - Burnett, Carol A.
T1 - The suicide mortality of working physicians and dentists.
JF - Occupational Medicine
JO - Occupational Medicine
JA - Occup Med (Lond)
Y1 - 2008/01//
VL - 58
IS - 1
SP - 25
EP - 29
CY - United Kingdom
PB - Oxford University Press
SN - 0962-7480
SN - 1471-8405
AD - Petersen, Martin R., National Institute of Occupational Safety and Health, Mail Stop R15, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-00348-005. PMID: 17965446 Partial author list: First Author & Affiliation: Petersen, Martin R.; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20080317. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Dentists; Physicians; Risk Factors; Suicide. Classification: Impaired Professionals (3470). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jan, 2008.
AB - Background: Some studies have shown that physicians and dentists have elevated risks of suicide, while other studies have not. Aims: Using all deaths and corresponding census data in 26 US states, we examine the suicide risk for working physicians and dentists. Methods: Death and census data for working people were obtained from 1984 through 1992. Directly age-standardized suicide rate ratios (SRRs) were calculated for white male and white female physicians and white male dentists. Results: For white female physicians, the suicide rate was elevated compared to the working US population (SRR = 2.39, 95% CI = 1.52-3.77). For white male physicians and dentists, the overall suicide rates were reduced (SRR = 0.80, 95% CI = 0.53-1.20 and 0.68, 95% CI = 0.52-0.89, respectively). For older white male physicians and dentists, however, observed suicide rates were elevated. Conclusions: White female physicians have an elevated suicide rate. Only older white male physicians and dentists have elevated suicide rates, which partially explains the varied conclusions in the literature. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide
KW - mortality
KW - physicians
KW - dentists
KW - risk factors
KW - 2008
KW - Death and Dying
KW - Dentists
KW - Physicians
KW - Risk Factors
KW - Suicide
KW - 2008
DO - 10.1093/occmed/kqm117
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00348-005&site=ehost-live&scope=site
UR - mrp1@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00323-005
AN - 2008-00323-005
AU - Englert, Regina C.
AU - Dauser, Deborah
AU - Gilchrist, Alice
AU - Samociuk, Holly A.
AU - Singh, Ravinder J.
AU - Kesner, James S.
AU - Cuthbert, Carla D.
AU - Zarfos, Kristen
AU - Gregorio, David I.
AU - Stevens, Richard G.
T1 - Marital status and variability in cortisol excretion in postmenopausal women.
JF - Biological Psychology
JO - Biological Psychology
JA - Biol Psychol
Y1 - 2008/01//
VL - 77
IS - 1
SP - 32
EP - 38
CY - Netherlands
PB - Elsevier Science
SN - 0301-0511
AD - Stevens, Richard G., Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, US, 06030-6325
N1 - Accession Number: 2008-00323-005. PMID: 17923241 Partial author list: First Author & Affiliation: Englert, Regina C.; Department of Community Medicine, University of Connecticut Health Center, Farmington, CT, US. Release Date: 20080204. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Females; Hydrocortisone; Marital Status; Menopause. Minor Descriptor: Marriage; Stress. Classification: Human Experimental Psychology (2300); Social Processes & Social Issues (2900). Population: Human (10); Female (40). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2008.
AB - Based on the premise that acute and chronic stresses stimulate and suppress cortisol secretion, respectively, and the hypothesis that marriage provides a buffer to stress, we tested whether extreme values of serum cortisol concentrations would be less likely in married women than in unmarried women. Three hundred women were recruited from two central Connecticut communities. Cortisol was measured in overnight urine samples using liquid chromatography-tandem mass spectrometry. Information on each subject's demographic characteristics, such as income and education level was collected. Mean log urinary cortisol was virtually identical in married and unmarried women, however, as predicted, the variance was significantly larger in the unmarried group (p = 0.01). After adjustment for potential confounders, multivariate logistic regression still revealed that absolute deviation of log10 cortisol from the mean was smaller for married versus unmarried women (p < 0.01); deviation from the mean cortisol was also higher for non-working than working women. These results support the idea that marriage and employment reduce the extreme levels of cortisol secretion, and by extension, this may reflect differences in levels of stress in married and in working women compared to unmarried and non-working women. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marital status
KW - cortisol excretion
KW - postmenopausal women
KW - 2008
KW - Human Females
KW - Hydrocortisone
KW - Marital Status
KW - Menopause
KW - Marriage
KW - Stress
KW - 2008
U1 - Sponsor: University of Connecticut Health Center, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Environmental Health Sciences. Grant: ES11659. Recipients: No recipient indicated
DO - 10.1016/j.biopsycho.2007.08.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00323-005&site=ehost-live&scope=site
UR - bugs@neuron.uchc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04566-004
AN - 2008-04566-004
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
AU - Choi, Sunha
AU - Lawrence, Lisa
AU - Brooks, Ashley
AU - Hasche, Leslie
AU - Dore, Peter
AU - Blinne, Wayne
T1 - Depression in public community long-term care: Implications for intervention development.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2008/01//
VL - 35
IS - 1
SP - 37
EP - 51
CY - Germany
PB - Springer
SN - 1094-3412
AD - Morrow-Howell, Nancy, Center for Mental Health Services Research, Washington University, Campus Box 1196, St. Louis, MO, US, 63130
N1 - Accession Number: 2008-04566-004. PMID: 18158624 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Morrow-Howell, Nancy; Center for Mental Health Services Research, Washington University, St. Louis, MO, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20080428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Improving Chronic Care Quality Conference, Sep, 2004, Columbia, MO, US. Major Descriptor: Dysthymic Disorder; Geriatric Patients; Long Term Care; Major Depression; Public Health Services. Minor Descriptor: Elder Care; Intervention; Mental Health Services. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Diagnostic Interview Schedule; Duke Depression Evaluation Schedule; Duke Life Event Scale; WHO-DAS II; SF-8; Nutritional Checklist; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Jan, 2008.
AB - The objective of this paper is to increase understanding of geriatric depression in the public community long-term care system to guide intervention development. Protocols included screening 1,170 new clients of a public community long-term care agency and interviewing all clients with major, dysthymia, or subthreshold depression (n = 299) and a randomly selected subset of nondepressed older adults (n = 315) at baseline, 6-month, and 1 year. Six percent had major depression, one-half of a percent had dysthymia only, and another 19% had subthreshold depression. Over the year observation period, 40% were persistently depressed; 32% were assessed as depressed only at the first observation; and the remainder was intermittently depressed. There were high levels of comorbid medical, functional, and psychosocial conditions. Mental health service use was low, and clients reported attitudinal and other barriers to depression treatment. Findings suggest the need for universal screening for depression with some strategies for triaging the most severely and persistently depressed for treatment. Although there will be challenges to the development of depression interventions, the public community long-term care system has high potential to assist vulnerable older adults receive help with depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - geriatric depression
KW - public community long-term care
KW - intervention development
KW - older adults
KW - major depression
KW - dysthymia
KW - subthreshold depression
KW - 2008
KW - Dysthymic Disorder
KW - Geriatric Patients
KW - Long Term Care
KW - Major Depression
KW - Public Health Services
KW - Elder Care
KW - Intervention
KW - Mental Health Services
KW - 2008
U1 - Sponsor: National Institute on Aging. Grant: R01 AG17451. Date: from 1999 to 2003. Recipients: No recipient indicated
DO - 10.1007/s11414-007-9098-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04566-004&site=ehost-live&scope=site
UR - Wayb7@yahoo.com
UR - pdore@wustl.edu
UR - lhasche@wustl.edu
UR - abrooks@cswe.org
UR - llawrence@wustl.edu
UR - shchoi@binghamton.edu
UR - ekp@wustl.edu
UR - morrow-howell@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01289-007
AN - 2008-01289-007
AU - Griswold, Kim S.
AU - Zayas, Luis E.
AU - Pastore, Patricia A.
AU - Smith, Susan J.
AU - Wagner, Christine M.
AU - Servoss, Timothy J.
T1 - Primary care after psychiatric crisis: A qualitative analysis.
JF - Annals of Family Medicine
JO - Annals of Family Medicine
JA - Ann Fam Med
Y1 - 2008/01//Jan-Feb, 2008
VL - 6
IS - 1
SP - 38
EP - 43
CY - US
PB - Annals of Family Medicine, Inc.
SN - 1544-1709
SN - 1544-1717
AD - Griswold, Kim S., Department of Family Medicine, SUNY Clinical Center, 462 Grider St, Buffalo, NY, US, 14215
N1 - Accession Number: 2008-01289-007. PMID: 18195313 Partial author list: First Author & Affiliation: Griswold, Kim S.; State University of New York at Buffalo, Department of Family Medicine, Family Medicine Research Institute, Buffalo, NY, US. Release Date: 20080901. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Primary Health Care; Psychiatric Patients; Treatment Barriers. Minor Descriptor: Client Attitudes; Crises; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jan-Feb, 2008.
AB - Purpose: Patients with serious psychiatric problems experience difficulty accessing primary care. The goals of this study were to assess whether care managers improved access and to understand patients' experiences with health care after a psychiatric crisis. Methods: A total of 175 consecutive patients seeking care in a psychiatric emergency department were randomly assigned to an intervention group with care managers or a control group. Brief, semistructured interviews about health care encounters were conducted at baseline and 1 year later. Five raters, using the content-driven, immersion-crystallization approach, analyzed 112 baseline and year-end interviews from 28 participants in each group. The main outcomes were patients' responses about their care experiences, connections with primary care, and integration of medical and mental health care. Scores for physical function and mental function were compared by analysis of variance (ANOVA). Results: At baseline, most participants described negative experiences in receiving care and emphasized the importance of listening, sensitivity, and respect. Fully 71% of patients in the intervention group said that having a care manager to assist them with primary care connections was beneficial. Patients in the intervention group had significantly better physical and mental function than their counterparts in the control group at 6 months (P = .03 for each) but not at 12 months. There was also a trend toward functional improvement over the course of the study in the intervention group. Conclusions: This analysis suggests that care management is effective in helping patients access primary care after a psychiatric crisis. It provides evidence on and insight into how care may be delivered more effectively for this population. Future work should assess the sustainability of care connections and longer-term patient health outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - primary care access
KW - psychiatric crisis
KW - care management
KW - 2008
KW - Health Care Delivery
KW - Primary Health Care
KW - Psychiatric Patients
KW - Treatment Barriers
KW - Client Attitudes
KW - Crises
KW - Mental Health Services
KW - 2008
DO - 10.1370/afm.760
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01289-007&site=ehost-live&scope=site
UR - griswol@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00881-008
AN - 2008-00881-008
AU - Tak, SangWoo
AU - Calvert, Geoffrey M.
T1 - Hearing difficulty attributable to employment by industry and occupation: An analysis of the National Health Interview Survey--United States, 1997 to 2003.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2008/01//
VL - 50
IS - 1
SP - 46
EP - 56
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - Tak, SangWoo, Surveillance Branch, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-00881-008. PMID: 18188081 Partial author list: First Author & Affiliation: Tak, SangWoo; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, US. Release Date: 20080825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Hearing Disorders; Occupational Exposure; Occupations. Minor Descriptor: Epidemiology. Classification: Vision & Hearing & Sensory Disorders (3299); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: National Health Interview Survey. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan, 2008.
AB - Objective: To estimate the national burden of hearing difficulty among workers in US industries and occupations. Methods: Data on 130,102 employed National Health Interview Survey respondents between the ages of 18 to 65 years who were interviewed between 1997 and 2003 were analyzed to estimate the population prevalence, adjusted prevalence ratios, and fractions of hearing difficulty attributable to employment. Results: The estimated population prevalence of hearing difficulty was 11.4% (24% attributable to employment). The adjusted prevalence ratios of hearing difficulty were highest for railroads, mining, and primary metal manufacturing industry. Occupations with increased risk of hearing difficulty were mechanics/repairers, machine operators, and transportation equipment operators. Conclusions: Hearing difficulty was differentially distributed across various industries. In industries with high rates, employers and workers should take preventive action to reduce the risk of occupational hearing loss. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hearing difficulty
KW - employment
KW - industry
KW - occupation
KW - National Health Interview Survey
KW - US
KW - prevalence
KW - 2008
KW - Hearing Disorders
KW - Occupational Exposure
KW - Occupations
KW - Epidemiology
KW - 2008
DO - 10.1097/JOM.0b013e3181579316
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00881-008&site=ehost-live&scope=site
UR - stak@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16986-005
AN - 2008-16986-005
AU - Wood, Fred B.
AU - Siegel, Elliot R.
AU - Feldman, Sue
AU - Love, Cynthia B.
AU - Rodrigues, Dennis
AU - Malamud, Mark
AU - Lagana, Marie
AU - Crafts, Jennifer
T1 - Web evaluation at the US National Institutes of Health: Use of the American customer satisfaction index online customer survey.
JF - Journal of Medical Internet Research
JO - Journal of Medical Internet Research
JA - J Med Internet Res
Y1 - 2008/01//Jan-Mar, 2008
VL - 10
IS - 1
SP - 51
EP - 70
CY - Canada
PB - Gunther Eysenbach
SN - 1438-8871
AD - Wood, Fred B., US National Institutes of Health, US Department of Health and Human Services, Office of Health Information Programs Development, US National Library of Medicine, 8600 Rockville Pike, Bldg 38, Room 2S-14, Bethesda, MD, US, 20894
N1 - Accession Number: 2008-16986-005. Partial author list: First Author & Affiliation: Wood, Fred B.; National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20090601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Satisfaction; Evaluation; Information Technology; Internet. Minor Descriptor: Teams. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: American Customer Satisfaction Index. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Jan-Mar, 2008.
AB - Background: The National Institutes of Health (NIH), US Department of Health and Human Services (HHS), realized the need to better understand its Web users in order to help assure that websites are user friendly and well designed for effective information dissemination. A trans-NIH group proposed a trans-NIH project to implement an online customer survey, known as the American Customer Satisfaction Index (ACSI) survey, on a large number of NIH websites—the first 'enterprise-wide' ACSI application, and probably the largest enterprise Web evaluation of any kind, in the US government. The proposal was funded by the NIH Evaluation Set-Aside Program for two years at a cost of US $1.5 million (US $1.275 million for survey licenses for 60 websites at US $18,000 per website; US $225,000 for a project evaluation contractor). Objective: The overall project objectives were to assess the value added to the participating NIH websites of using the ACSI online survey, identify any NIH-wide benefits (and limitations) of the ACSI, ascertain any new understanding about the NIH Web presence based on ACSI survey results, and evaluate the effectiveness of a trans-NIH approach to Web evaluation. This was not an experimental study and was not intended to evaluate the ACSI survey methodology, per se, or the impacts of its use on customer satisfaction with NIH websites. Methods: The evaluation methodology included baseline pre-project websites profiles; before and after email surveys of participating website teams; interviews with a representative cross-section of website staff; observations of debriefing meetings with website teams; observations at quarterly trans-NIH Web staff meetings and biweekly trans-NIH leadership team meetings; and review and analysis of secondary data. Results: Of the original 60 NIH websites signed up, 55 implemented the ACSI survey, 42 generated sufficient data for formal reporting of survey results for their sites, and 51 completed the final project survey. A broad cross-section of websites participated, and a majority reported significant benefits and new knowledge gained from the ACSI survey results. NIH websites as a group scored consistently higher on overall customer satisfaction relative to US government-wide and private sector benchmarks. Conclusions: Overall, the enterprise-wide experiment was successful. On the level of individual websites, the project confirmed the value of online customer surveys as a Web evaluation method. The evaluation results indicated that successful use of the ACSI, whether site-by-site or enterprise-wide, depends in large part on strong staff and management support and adequate funding and time for the use of such evaluative methods. In the age of Web-based e-government, a broad commitment to Web evaluation may well be needed. This commitment would help assure that the potential of the Web and other information technologies to improve customer and citizen satisfaction is fully realized. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - web evaluation
KW - customer satisfaction
KW - online customer survey
KW - information technologies
KW - 2008
KW - Consumer Satisfaction
KW - Evaluation
KW - Information Technology
KW - Internet
KW - Teams
KW - 2008
U1 - Sponsor: National Institutes of Health, Office of the Director (OD), Evaluation Branch (EB), US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Recipients: No recipient indicated
DO - 10.2196/jmir.944
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16986-005&site=ehost-live&scope=site
UR - fredwood@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00016-007
AN - 2008-00016-007
AU - Reynolds, Nancy R.
AU - Testa, Marcia A.
AU - Su, Max
AU - Chesney, Margaret A.
AU - Neidig, Judith L.
AU - Frank, Ian
AU - Smith, Scott
AU - Ickovics, Jeannette
AU - Robbins, Gregory K.
T1 - Telephone support to improve antiretroviral medication adherence: A multisite, randomized controlled trial.
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2008/01//
VL - 47
IS - 1
SP - 62
EP - 68
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Reynolds, Nancy R., Ohio State University, 1585 Neil Ave., Columbus, OH, US, 43210
N1 - Accession Number: 2008-00016-007. Partial author list: First Author & Affiliation: Reynolds, Nancy R.; AIDS Clinical Trials Unit, Ohio State University, Columbus, OH, US. Institutional Authors: AIDS Clinical Trials Group 731 and 384 Teams. Release Date: 20080825. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Robbins, Gregory K. Major Descriptor: Antiviral Drugs; Drug Therapy; HIV; Telephone Systems; Treatment Compliance. Minor Descriptor: At Risk Populations; Treatment Outcomes. Classification: Health Psychology & Medicine (3360). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: ACTG Adherence Questionnaire. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2008.
AB - Objective: To determine whether proactive telephone support improves adherence to antiretroviral therapy (ART) and clinical outcomes when compared to standard care. Methods: A multisite, randomized controlled trial (RCT) was conducted with 109 ART-naive subjects coenrolled in AIDS Clinical Trials Group (ACTG) 384. Subjects received standard clinic-based patient education (SC) or SC plus structured proactive telephone calls. The customized calls were conducted from a central site over 16 weeks by trained registered nurses. Outcome measures (collected over 64 weeks) included an ACTG adherence questionnaire and 384 study endpoints. Results: For the primary endpoint, self-reported adherence, a significantly better overall treatment effect was observed in the telephone group (P = 0.023). In a post hoc analysis, composite adherence scores, taken as the first 2 factor scores from a principal components analysis, also found significant intervention benefit (P = 0.023 and 0.019 respectively). For the 384 primary study endpoint, time to regimen failure, the Kaplan-Meier survival curve for the telephone group remained above the SC group at weeks 20 to 64; a Cox proportional hazard model that controlled for baseline RNA stratification, CD4, gender, age, race/ethnicity, and randomized ART treatment arm suggested the telephone group tended to have a lower risk for failure (hazard ratio = 0.68; 95% confidence interval: 0.38 to 1.23). Conclusions: Findings indicate that customized, proactive telephone calls have good potential to improve long-term adherence behavior and clinical outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - telephone support
KW - antiretroviral medication
KW - treatment adherence
KW - clinical outcomes
KW - 2008
KW - Antiviral Drugs
KW - Drug Therapy
KW - HIV
KW - Telephone Systems
KW - Treatment Compliance
KW - At Risk Populations
KW - Treatment Outcomes
KW - 2008
U1 - Sponsor: National Institutes of Health, National Institute of Allergy and Infectious Diseases, AIDS Clinical Trials Group, US. Grant: AI068636. Recipients: No recipient indicated
U1 - Sponsor: Ohio State University, US. Grant: AI069474. Recipients: No recipient indicated
U1 - Sponsor: Harvard University, US. Grant: AI069472. Recipients: No recipient indicated
U1 - Sponsor: University of North Carolina, US. Grant: AI25868. Recipients: No recipient indicated
U1 - Sponsor: University of Pennsylvania, AIDS Clinical Trial Unit, US. Grant: AI032783. Recipients: No recipient indicated
U1 - Sponsor: Sponsor name not included. Grant: 1K01AI062435. Recipients: Robbins, Gregory K.
U1 - Sponsor: Sponsor name not included, US. Grant: R01 NR05108; AI069419. Recipients: Reynolds, Nancy R.
U1 - Sponsor: Sponsor name not included, US. Grant: AI-45008. Recipients: Frank, Ian
DO - 10.1097/QAI.0b013e3181582d54
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00016-007&site=ehost-live&scope=site
UR - reynolds.1@osu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04566-008
AN - 2008-04566-008
AU - Bray, Jeremy
AU - Vandivort, Rita
AU - Dilonardo, Joan
AU - Dunlap, Laura
AU - Schroeder, Don
AU - Forhan, Carol
AU - Miller, Kay
T1 - Healthcare utilization of individuals with opiate use disorders: An analysis of integrated Medicaid and state mental health/substance abuse agency data.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2008/01//
VL - 35
IS - 1
SP - 91
EP - 106
CY - Germany
PB - Springer
SN - 1094-3412
AD - Bray, Jeremy, Behavioral Health Economics Program, RTI International, 3040 Cornwallis Road, Research Triangle Park, NC, US, 27709
N1 - Accession Number: 2008-04566-008. PMID: 17554630 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Bray, Jeremy; Behavioral Health Economics Program, RTI International, Research Triangle Park, NC, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20080428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Health Care Utilization; Mental Health Services; Opiates. Minor Descriptor: Medicaid; Public Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jan, 2008.
AB - Data from the Substance Abuse and Mental Health Services Administration's Integrated Database (IDB) were used to examine the service use patterns of individuals with possible opiate use disorders in Washington State. Results indicate that regardless of Medicaid enrollment status, individuals who received mental health (MH) or substance abuse (SA) services only through state agencies received no inpatient substance abuse service. Furthermore, when compared with individuals who received at least one MH/SA service through Medicaid, those who received services only through the state agencies were less likely to have received any MH services and were more likely to have received residential SA services. This analysis highlights the importance of using integrated client data in providing a more comprehensive understanding of services to inform policy and raises significant questions about how regulatory requirements affecting different funding mechanisms might drive settings of care in ways not related to the care needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - healthcare utilization
KW - opiate use disorders
KW - Medicaid
KW - state mental health & substance abuse services
KW - 2008
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Health Care Utilization
KW - Mental Health Services
KW - Opiates
KW - Medicaid
KW - Public Health Services
KW - 2008
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1007/s11414-007-9067-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04566-008&site=ehost-live&scope=site
UR - kay.miller@thomson.com
UR - carol.forhan@thomson.com
UR - don.schroeder@thomson.com
UR - ljd@rti.org
UR - rita.vandivort@samhsa.hhs.gov
UR - bray@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05810-004
AN - 2008-05810-004
AU - Howard, John
T1 - Prevention through design-Introduction.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 2
SP - 113
EP - 113
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Howard, John
N1 - Accession Number: 2008-05810-004. PMID: 18454949 Partial author list: First Author & Affiliation: Howard, John; National Institute for Occupational Safety and Health, US. Release Date: 20080526. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hazards; Industrial Accidents; Occupational Safety; Prevention; Working Conditions. Minor Descriptor: Death and Dying; Health. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Page Count: 1. Issue Publication Date: 2008.
AB - One of the best ways to prevent and control occupational injuries, illnesses, and fatalities is to 'design out' or minimize hazards and risks early in the design process. The National Institute for Occupational Safety and Health (NIOSH) is leading a national initiative called Prevention through Design (PtD) to promote this concept and highlight its importance in all business decisions. PtD addresses occupational safety and health needs in the design process to prevent or minimize the work-related hazards and risks associated with the construction, manufacture, use, maintenance, and disposal of facilities, materials, and equipment. The ultimate goal of the PtD Initiative is to prevent or reduce occupational injuries, illnesses, and fatalities through the inclusion of prevention considerations into all designs that impact workers. This edition of the Journal of Safety Research is devoted to PtD and includes the proceedings from the Prevention through Design Workshop meeting, breakout session reports from the industry sectors and functional areas, as well as technical papers authored by experts in PtD. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention through design
KW - occupational injuries
KW - fatalities
KW - design process
KW - 2008
KW - Hazards
KW - Industrial Accidents
KW - Occupational Safety
KW - Prevention
KW - Working Conditions
KW - Death and Dying
KW - Health
KW - 2008
DO - 10.1016/j.jsr.2008.02.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05810-004&site=ehost-live&scope=site
UR - jhoward1@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05810-005
AN - 2008-05810-005
AU - Schulte, Paul A.
AU - Rinehart, Richard
AU - Okun, Andrea
AU - Geraci, Charles L.
AU - Heidel, Donna S.
T1 - National prevention through design (PtD) initiative.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 2
SP - 115
EP - 121
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Schulte, Paul A.
N1 - Accession Number: 2008-05810-005. PMID: 18454950 Partial author list: First Author & Affiliation: Schulte, Paul A.; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US. Release Date: 20080526. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hazards; Industrial Accidents; Occupational Safety; Working Conditions. Minor Descriptor: Death and Dying; Injuries; Prevention. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: 2008.
AB - Introduction: The most effective means of preventing and controlling occupational injuries, illness, and fatalities is to 'design out' hazards and hazardous exposures from the workplace. There is a long history of designing for safety for the general public and to a lesser degree for workers. Method: We now have the experience and insight from thoughtful, previous efforts to call for a comprehensive national strategy to implement a Prevention through Design (PtD) Initiative. Results: This paper describes that initiative in terms of four overarching areas where action can be directed: practice, policy, research, and education. To obtain stakeholder input for issues in these four areas and to focus implementation efforts, eight sector divisions of the economy will be addressed. A seven year strategy is envisioned. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention through design initiative
KW - occupational injuries
KW - fatalities
KW - hazardous exposures
KW - workplace
KW - 2008
KW - Hazards
KW - Industrial Accidents
KW - Occupational Safety
KW - Working Conditions
KW - Death and Dying
KW - Injuries
KW - Prevention
KW - 2008
DO - 10.1016/j.jsr.2008.02.021
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05810-005&site=ehost-live&scope=site
UR - pas4@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00212-016
AN - 2008-00212-016
AU - Snowden, Lonnie R.
AU - Masland, Mary C.
AU - Libby, Anne M.
AU - Wallace, Neal
AU - Fawley, Kya
T1 - Racial/ethnic minority children's use of psychiatric emergency care in California's public mental health system.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/01//
VL - 98
IS - 1
SP - 118
EP - 124
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Snowden, Lonnie R., University of California, 120 Haviland Hall, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2008-00212-016. PMID: 18048783 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley, CA, US. Release Date: 20080407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Crisis Intervention Services; Emergency Services; Mental Health Services; Public Health; Racial and Ethnic Differences. Minor Descriptor: Racial and Ethnic Groups. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2008.
AB - Objectives: We examined rates and intensity of crisis services use by race/ethnicity for 351174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. Methods: We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). Results: African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. Conclusions: African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial & ethnic minority
KW - children's use
KW - psychiatric emergency care
KW - public mental health system
KW - crisis services
KW - 2008
KW - Crisis Intervention Services
KW - Emergency Services
KW - Mental Health Services
KW - Public Health
KW - Racial and Ethnic Differences
KW - Racial and Ethnic Groups
KW - 2008
U1 - Sponsor: National Institute of Mental Health. Grant: R01 MH067871. Recipients: No recipient indicated
DO - 10.2105/AJPH.2006.105361
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00212-016&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-12567-007
AN - 2010-12567-007
AU - Strine, Tara W.
AU - Mokdad, Ali H.
AU - Balluz, Lina S.
AU - Berry, Joyce T.
AU - Gonzalez, Olinda
T1 - Impact of depression and anxiety on quality of life, health behaviors, and asthma control among adults in the United States with asthma, 2006.
JF - Journal of Asthma
JO - Journal of Asthma
JA - J Asthma
Y1 - 2008///
VL - 45
IS - 2
SP - 123
EP - 133
CY - US
PB - Informa Healthcare
SN - 0277-0903
SN - 1532-4303
AD - Strine, Tara W., Division of Adult and Community Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-66, Atlanta, GA, US, 30341
N1 - Accession Number: 2010-12567-007. PMID: 18350404 Other Journal Title: Journal of Asthma Research. Partial author list: First Author & Affiliation: Strine, Tara W.; Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, US. Other Publishers: Taylor & Francis. Release Date: 20110131. Correction Date: 20150928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Anxiety; Asthma; Health Behavior; Major Depression; Quality of Life. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: Georgia; US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Patient Health Questionnaire 8; Adult Asthma History Module; Healthy Days Symptoms Module; Behavioral Risk Surveillance Survey; Anxiety and Depression Module. Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: 2008.
AB - Background: Psychological factors such as anxiety and depression are increasingly being recognized as influencing the onset and course of asthma. Methods: We obtained Patient Health Questionnaire 8 depression data from 41 states and territories using the 2006 Behavioral Risk Factor Surveillance System. Heath risk behaviors, social and emotional support, life satisfaction, disability, and four health-related quality-of-life (HRQOL) questions were available for all states and territories (n = 18,856 with asthma). Five additional HRQOL questions were asked in three states (n = 1345 persons with asthma), and questions assessing asthma control were available for nine states (n = 3943 persons with asthma). Results: Persons with asthma were significantly more likely than those without asthma to have current depression (19.4% vs. 7.7%), a lifetime diagnosis of depression (30.6% vs. 14.4%), and anxiety (23.5% vs. 10.2%). For most domains examined, there was a dose-response relationship between level of depression severity and mean number of days of impaired HRQOL in the past 30 days, as well as an increased prevalence of life dissatisfaction, inadequate social support, disability, and risk behaviors, such as smoking, physical inactivity, and obesity, among those with asthma. Moreover, depression and anxiety were associated with a decreased level of asthma control, including more visits to the doctor or emergency room, inability to do usual activities, and more days of symptoms compared to those without depression or anxiety. Conclusion: This research indicates that a multidimensional, integrative approach to health care should be considered when assessing patients with asthma. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - anxiety
KW - quality of life
KW - health behavior
KW - asthma control
KW - 2008
KW - Anxiety
KW - Asthma
KW - Health Behavior
KW - Major Depression
KW - Quality of Life
KW - 2008
DO - 10.1080/02770900701840238
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-12567-007&site=ehost-live&scope=site
UR - tws2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14248-003
AN - 2008-14248-003
AU - Sahahan, Nancy
AU - Kullman, Gregory
AU - Lynch, David
AU - Kreiss, Kathleen
T1 - Asthma arising in flavoring-exposed food production workers.
JF - International Journal of Occupational Medicine and Environmental Health
JO - International Journal of Occupational Medicine and Environmental Health
JA - Int J Occup Med Environ Health
Y1 - 2008///
VL - 21
IS - 2
SP - 173
EP - 177
CY - Poland
PB - Nofer Institute of Occupational Medicine
SN - 1232-1087
SN - 1896-494X
AD - Kreiss, Kathleen, Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Suite H2800, Morgantown, WV, US, 26505
N1 - Accession Number: 2008-14248-003. Partial author list: First Author & Affiliation: Sahahan, Nancy; Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Versita. Release Date: 20091026. Correction Date: 20160201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Asthma; Occupational Exposure; Personnel; Respiratory Tract Disorders. Minor Descriptor: Chemicals; Food. Classification: Working Conditions & Industrial Safety (3670); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: 2008. Publication History: Accepted Date: Apr 24, 2008; First Submitted Date: Feb 7, 2008.
AB - Objectives: While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease. Materials and Methods: We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers. Results: Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - asthma
KW - food production workers
KW - respiratory disease
KW - flavoring chemicals exposure
KW - 2008
KW - Asthma
KW - Occupational Exposure
KW - Personnel
KW - Respiratory Tract Disorders
KW - Chemicals
KW - Food
KW - 2008
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, US. Recipients: No recipient indicated
DO - 10.2478/v10001-008-0019-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14248-003&site=ehost-live&scope=site
UR - KKreiss@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18747-005
AN - 2008-18747-005
AU - Edens, John F.
AU - Vincent, Gina M.
T1 - Juvenile psychopathy: A clinical construct in need of restraint?
JF - Journal of Forensic Psychology Practice
JO - Journal of Forensic Psychology Practice
JA - J Forensic Psychol Pract
Y1 - 2008///
VL - 8
IS - 2
SP - 186
EP - 197
CY - US
PB - Haworth Press
SN - 1522-8932
SN - 1522-9092
AD - Edens, John F., Department of Psychology, Southern Methodist University, 310D Hyer Hall, Dallas, TX, US, 75275-0442
N1 - Accession Number: 2008-18747-005. Partial author list: First Author & Affiliation: Edens, John F.; Department of Psychology, Southern Methodist University, Dallas, TX, US. Other Publishers: Taylor & Francis. Release Date: 20090706. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Decision Making; Forensic Psychology; Psychopathy. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10). References Available: Y. Page Count: 12. Issue Publication Date: 2008.
AB - Interest in psychopathic traits and their potential applicability to youths appears to be increasing precipitously in the social sciences. Although research on the causes, correlates, and course of traits that appear phenotypically similar to adult psychopathy potentially may inform clinical and legal decision making for youths some day, there are numerous problems with taking measures of these putative traits 'outside the lab' at present. This article highlights several unresolved questions regarding juvenile psychopathy that seriously limit its applied utility in clinical and forensic decision making. Examiners who plan to use instruments intended to measure this construct among youths are advised to be familiar with these limitations and their implications for practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - juvenile psychopathy
KW - clinical decision making
KW - forensic decision making
KW - 2008
KW - Decision Making
KW - Forensic Psychology
KW - Psychopathy
KW - 2008
DO - 10.1080/15228930801964042
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18747-005&site=ehost-live&scope=site
UR - jedens@smu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05810-022
AN - 2008-05810-022
AU - Bealko, Susan B.
AU - Kovalchik, Peter G.
AU - Matetic, Rudy J.
T1 - Mining sector.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 2
SP - 187
EP - 189
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Bealko, Susan B.
N1 - Accession Number: 2008-05810-022. PMID: 18454967 Partial author list: First Author & Affiliation: Bealko, Susan B.; National Institute for Occupational Safety and Health (NIOSH), US. Release Date: 20080526. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Occupational Safety; Prevention. Minor Descriptor: Copper; Economy; Modernization. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Page Count: 3. Issue Publication Date: 2008.
AB - Mining provides a large part of the energy and raw materials that feed this Nation's economy. Copper pipe, concrete, and window glass serve as well known examples of the reliance on minerals in modern society. The mining sector breakout session workgroup discussed the mission of the PtD workshop and the role of the four functional areas: practice, policy, research, and education. The participants agreed on specific research areas where additional mining stakeholder collaborations and PtD applications were greatly needed. They included the following: health standards (in particular, the newly proposed coal mine dust standard), disaster prevention, and mine emergency response. In conclusion, the general consensus from the members of the mining sector established the need for several key endeavors. More and stronger mining collaborations and partnerships need to be established among stakeholders, as well as the international mining community. Communication and marketing of PtD strategies, designs, and products should be improved. Regulatory agencies need to be involved early in the PtD process. And finally, there is a great need to educate mining stakeholders and students, from the undergraduate level and up, about the benefits of the PtD initiative. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mining sector
KW - mining community
KW - prevention through design
KW - minerals
KW - 2008
KW - Health
KW - Occupational Safety
KW - Prevention
KW - Copper
KW - Economy
KW - Modernization
KW - 2008
DO - 10.1016/j.jsr.2008.02.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05810-022&site=ehost-live&scope=site
UR - sbealko@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05810-030
AN - 2008-05810-030
AU - Chapman, Larry J.
AU - Newenhouse, Astrid C.
AU - Pereira, Kathryn M.
AU - Karsh, Ben-Tzion
AU - Meyer, Robert M.
AU - Brunette, Christopher M.
AU - Ehlers, Janet J.
T1 - Evaluation of a four year intervention to reduce musculoskeletal hazards among berry growers.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 2
SP - 215
EP - 224
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Chapman, Larry J., Biological Systems Engineering Department, University of Wisconsin, 460 Henry Mall, Madison, WI, US, 53706
N1 - Accession Number: 2008-05810-030. PMID: 18454973 Partial author list: First Author & Affiliation: Chapman, Larry J.; Biological Systems Engineering Department, University of Wisconsin, Madison, WI, US. Release Date: 20080526. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Agricultural Workers; Intervention; Musculoskeletal Disorders; Risk Factors; Working Conditions. Minor Descriptor: Evaluation; Injuries. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: New Zealand; US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2008.
AB - Problem: Fresh market berry production workers are exposed to physical risk factors for musculoskeletal injury. Method: We disseminated information through trade publications and other sources to berry managers in seven U.S. states about five prevention through design practices that were both safer and more profitable than traditional methods. We administered mail evaluation questionnaires prior to the intervention and after each of four intervention years to rolling, independent U.S. samples and to comparison New Zealand berry farm manager samples after years one through three. Results: U.S. manager self-reports of reading trade publication information increased compared to baseline values for two of five practices and self-reported awareness increased for four of five practices. There were no increases in adoption. More U.S. than New Zealand managers reported getting information about two practices from trade publications and about four practices from public events. No U.S. versus New Zealand differences were observed in reported awareness or adoption for any practice. Impact on Industry: This study showed that even a modest campaign can build awareness of safer practices fairly quickly in three to four years among small agricultural firms but that increasing adoption apparently requires more time. Widespread adoption of safer practices could help keep operators in business longer as they age by reducing the workload and musculoskeletal strain associated with labor intensive crop production for them and their workforce. Adoption of practices that also improve profits, like the five practices featured in this study, could also help managers stay in business. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intervention
KW - evaluation
KW - musculoskeletal hazards
KW - berry growers
KW - physical risk factors
KW - design practices
KW - 2008
KW - Agricultural Workers
KW - Intervention
KW - Musculoskeletal Disorders
KW - Risk Factors
KW - Working Conditions
KW - Evaluation
KW - Injuries
KW - 2008
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Grant: U06/CCU517553; U01/OH008100. Other Details: Supported through two Community Partners for Healthy Farming cooperative agreements,Federal grant. Recipients: No recipient indicated
DO - 10.1016/j.jsr.2008.02.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05810-030&site=ehost-live&scope=site
UR - ljchapma@wisc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01010-029
AN - 2008-01010-029
AU - Chen, Guang Xiang
T1 - Impact of federal compliance reviews of trucking companies in reducing highway truck crashes.
JF - Accident Analysis and Prevention
JO - Accident Analysis and Prevention
JA - Accid Anal Prev
Y1 - 2008/01//
VL - 40
IS - 1
SP - 238
EP - 245
CY - Netherlands
PB - Elsevier Science
SN - 0001-4575
AD - Chen, Guang Xiang, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2008-01010-029. PMID: 18215554 Partial author list: First Author & Affiliation: Chen, Guang Xiang; National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, US. Release Date: 20080211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Automobiles; Business Organizations; Highway Safety; Motor Traffic Accidents. Minor Descriptor: Government Policy Making; Law Enforcement; Organizational Behavior. Classification: Transportation (4090); Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2008.
AB - Background: The compliance review (CR) is a federal program monitoring motor carrier safety performance and regulatory compliance. This study sought to assess the impact of CRs on reviewed trucking companies in reducing truck crashes. Methods: Data was from the Motor Carrier Management Information System. Study subjects were trucking companies established during 1990-1995, had at least one truck, and remained active until April 2004. Truck crash data of these companies was examined from 1996 to 2003. The crash rates in 2003 and annual percentage changes in number of crashes were computed. Analyses were stratified by company size, organization, operation classification, and safety rating. Results: Companies that received CRs had a higher crash rate than never-reviewed companies. Reviewed companies experienced a 39-15% reduction in number of crashes in the year the CR was performed. The reduction in crashes was observed in all reviewed companies regardless of company size, operation classification, type of organization, or safety rating. The reduction in crashes was sustained for at least 7 years after CRs. Discussion: The study results were controlled for the year in which CRs were performed, crash trend, and CR selection bias. However, further studies, especially a randomized prospective longitudinal study, are needed to overcome the limitations that are associated with an observation study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - federal compliance reviews
KW - trucking companies
KW - highway truck crashes
KW - safety performance
KW - regulatory compliance
KW - 2008
KW - Accident Prevention
KW - Automobiles
KW - Business Organizations
KW - Highway Safety
KW - Motor Traffic Accidents
KW - Government Policy Making
KW - Law Enforcement
KW - Organizational Behavior
KW - 2008
DO - 10.1016/j.aap.2007.06.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01010-029&site=ehost-live&scope=site
UR - gchen@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18931-005
AN - 2008-18931-005
AU - Fluet, Christina
AU - Turner, Sandra
AU - Collamore, Barry
AU - Grossman-McKee, Doug
AU - Perrin, James
AU - Epstein, Susan
AU - Allen, Deborah
AU - Anderson, Betsy
AU - Wells, Nora
AU - Kuhlthau, Karen
AU - Honberg, Lynda
T1 - Three workplace models for children with special needs.
JF - Journal of Workplace Behavioral Health
JO - Journal of Workplace Behavioral Health
JA - J Workplace Behav Health
Y1 - 2008///
VL - 23
IS - 3
SP - 245
EP - 262
CY - US
PB - Haworth Press
SN - 1555-5240
SN - 1555-5259
AD - Fluet, Christina, MA Consortium for Children with Special Health Care Needs, 101 Tremont Street, Suite 812, Boston, MA, US, 02108
N1 - Accession Number: 2008-18931-005. Other Journal Title: Employee Assistance Quarterly. Partial author list: First Author & Affiliation: Fluet, Christina; Massachusetts General Hospital, Center for Child and Adolescent Health Policy, Boston, MA, US. Other Publishers: Taylor & Francis. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Assistance Programs; Family Members; Organizational Commitment; Retention; Special Needs. Classification: Occupational Interests & Guidance (3610). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 18. Issue Publication Date: 2008.
AB - Employees caring for dependent family members face complex challenges in their personal and professional lives. Employee benefit programs can provide important support for those facing these circumstances. When the dependent is a child with a special need, workplace programs can help families more effectively utilize employee benefits and access public and private resources. Employee assistance and work-life programs are particularly well suited for addressing the needs of these employees and their children. In 2005, three large U.S. employers implemented programs specifically for employees who have children with special needs. These employers reported positive impacts on employee retention and commitment, improved utilization of employee benefit programs, and improved promotion of corporate diversity objectives. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - special needs
KW - family members
KW - employee benefit programs
KW - employee retention
KW - employee commitment
KW - 2008
KW - Employee Assistance Programs
KW - Family Members
KW - Organizational Commitment
KW - Retention
KW - Special Needs
KW - 2008
U1 - Sponsor: DHHS, Maternal and Child Health Bureau. Grant: Cooperative Agreement 1U93MC00183. Recipients: No recipient indicated
DO - 10.1080/15555240802241611
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18931-005&site=ehost-live&scope=site
UR - lhonberg@hrsa.gov
UR - kkuhlthau@partners.org
UR - cfluet@neserve.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05810-034
AN - 2008-05810-034
AU - Kovalchik, Peter G.
AU - Matetic, Rudy J.
AU - Smith, Adam K.
AU - Bealko, Susan B.
T1 - Application of prevention through design for hearing loss in the mining industry.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 2
SP - 251
EP - 254
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Kovalchik, Peter G.
N1 - Accession Number: 2008-05810-034. PMID: 18454977 Partial author list: First Author & Affiliation: Kovalchik, Peter G.; National Institute for Occupational Safety and Health, GA, US. Release Date: 20080526. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hearing Disorders; Noise Effects; Occupational Safety; Prevention; Working Conditions. Minor Descriptor: Hazards; Warnings. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: 2008.
AB - Introduction: Overexposure to noise remains a widespread and serious health hazard in the U.S. service providing and goods producing industries. Excessive noise can lead to poor verbal communication and reduce the ability to recognize warning signals. These dangerous work conditions can also cause stress and fatigue. Occupational hearing loss is a permanent illness, with no recovery currently possible. Method: National Institute for Occupational Safety and Health (NIOSH) has recognized Noise Induced Hearing Loss (NIHL) as one of the ten leading work-related diseases and injuries in the United States, and has emphasized its importance as one of the critical areas expressed in the National Occupational Research Agenda. Results: One of the most serious noise problems in the goods producing industries is the operation of continuous mining machines during underground coal mining. In order to minimize occupational hearing loss, noise hazards are 'designed out' early in the design process. NIOSH is leading a national initiative called Prevention through Design (PTD) to promote this concept. This paper describes the quiet-by-design approach of a noise control that reduced noise exposures of continuous mining machine operators by 3dB(A) using the four functional areas of PTD, namely Practice, Policy, Research, and Education. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevention
KW - design
KW - hearing loss
KW - mining industry
KW - overexposure
KW - noise
KW - warning signals
KW - 2008
KW - Hearing Disorders
KW - Noise Effects
KW - Occupational Safety
KW - Prevention
KW - Working Conditions
KW - Hazards
KW - Warnings
KW - 2008
DO - 10.1016/j.jsr.2008.02.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05810-034&site=ehost-live&scope=site
UR - PKovalchik@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18748-007
AN - 2008-18748-007
AU - Vincent, Gina M.
AU - Kinscherff, Robert
T1 - The use of psychopathy in violence risk assessments of adolescent females.
JF - Journal of Forensic Psychology Practice
JO - Journal of Forensic Psychology Practice
JA - J Forensic Psychol Pract
Y1 - 2008///
VL - 8
IS - 3
SP - 309
EP - 320
CY - US
PB - Haworth Press
SN - 1522-8932
SN - 1522-9092
AD - Vincent, Gina M., Center of Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, WSH 8B-21, Worcester, MA, US, 01604
N1 - Accession Number: 2008-18748-007. Partial author list: First Author & Affiliation: Vincent, Gina M.; Center of Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Other Publishers: Taylor & Francis. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Forensic Psychiatry; Mental Health Personnel; Psychopathy; Violence; Risk Assessment. Minor Descriptor: Clinicians. Classification: Professional Psychological & Health Personnel Issues (3400); Forensic Psychology & Legal Issues (4200). Population: Human (10); Female (40). Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Psychopathy Checklist. Methodology: Clinical Case Study. References Available: Y. Page Count: 12. Issue Publication Date: 2008.
AB - Forensic mental health clinicians frequently are called on to conduct assessments of youths' risk for future violence and offending. The fastest rising demographic group requiring these risk assessments is adolescent girls. This case report illustrates how the Psychopathy Checklist: Youth Version (PCL:YV) can be used in risk assessment, as in the case of a 15-year-old girl. As is illustrated, the benefit of using the PCL:YV in a young offender case should be weighed against the potential detrimental effects on the life of the youth. This case report provides specific recommendations about how to apply the PCL:YV with extreme caution when conducting such risk assessments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychopathy
KW - violence risk assessments
KW - adolescent females
KW - forensic mental health clinicians
KW - 2008
KW - Forensic Psychiatry
KW - Mental Health Personnel
KW - Psychopathy
KW - Violence
KW - Risk Assessment
KW - Clinicians
KW - 2008
DO - 10.1080/15228930802282063
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18748-007&site=ehost-live&scope=site
UR - rkinscherff@eastersealsnh.org
UR - Gina.Vincent@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08653-014
AN - 2008-08653-014
AU - Quick, Brian L.
AU - Stephenson, Michael T.
AU - Witte, Kim
AU - Vaught, Charles
AU - Booth-Butterfield, Steve
AU - Patel, Dhaval
T1 - An examination of antecedents to coal miners' hearing protection behaviors: A test of the theory of planned behavior.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 3
SP - 329
EP - 338
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Quick, Brian L., Department of Communication, University of Illinois at Urbana-Champaign, Urbana, IL, US, 61801
N1 - Accession Number: 2008-08653-014. PMID: 18571575 Partial author list: First Author & Affiliation: Quick, Brian L.; Department of Communication, University of Illinois at Urbana-Champaign, Urbana, IL, US. Release Date: 20080707. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Attitudes; Hearing Disorders; Planned Behavior; Prevention; Safety Devices. Minor Descriptor: Blue Collar Workers; Health Promotion. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: 2008.
AB - Problem: The National Institute for Occupational Safety and Health's [NIOSH] National Occupational Research Agenda (DHHS Publication No. 96-115) reports that approximately 50% of miners will experience hearing loss by age 50, compared to only 9% of the general population. The present investigation examines three antecedents believed to be associated with miner's use of hearing protection. Method: A posttest-delayed-posttest-control group field research design was employed to assess antecedents toward wearing hearing protection. Results: Following the initial posttest, miners' attitudes and subjective norms were antecedents to intentions to wear hearing protection devices. Also, intentions toward wearing hearing protection predicted hearing protection behaviors. Approximately six weeks later, miners' attitudes and perceived behavioral control were each significant predictors of intentions to wear hearing protection and again, intentions were positively associated with hearing protection behaviors. Impact on Industry: Our results indicate that appeals to normative influences may be the most effective antecedent to employ when persuading coal miners to wear hearing protection. However, messages designed to impact attitudes and perceived behavioral control were also effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - coal miners' attitudes
KW - hearing protection behaviors
KW - theory of planned behavior
KW - 2008
KW - Employee Attitudes
KW - Hearing Disorders
KW - Planned Behavior
KW - Prevention
KW - Safety Devices
KW - Blue Collar Workers
KW - Health Promotion
KW - 2008
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Grant: BH61-8533. Recipients: No recipient indicated
DO - 10.1016/j.jsr.2008.02.032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08653-014&site=ehost-live&scope=site
UR - bquick@uiuc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16696-010
AN - 2008-16696-010
AU - Loringer, Kelly A.
AU - Myers, John R.
T1 - Tracking the prevalence of rollover protective structures on U.S. farm tractors: 1993, 2001, and 2004.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2008///
VL - 39
IS - 5
SP - 509
EP - 517
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
N1 - Accession Number: 2008-16696-010. PMID: 19010124 Partial author list: First Author & Affiliation: Loringer, Kelly A.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20090706. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Accidents; Agricultural Workers; Death and Dying; Intervention. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: 2008.
AB - Problem: Between 1992 and 2005, 1412 workers on farms died from tractor overturns. A Rollover Protective Structure (ROPS) is a proven intervention to reduce overturn deaths. However, farm characteristics that are associated with the adoption of ROPS are not well understood. Methods: ROPS prevalence statistics were derived from National Institute for Occupational Safety and Health (NIOSH) surveys that tracked ROPS use on farms. Data were from the years 1993, 2001, and 2004. Results: In 1993, 38% of tractors were equipped with ROPS. This increased to 51% by 2004. ROPS prevalence rates were higher on farms in the Southern region of the United States, on farms where the operator was 25-34 years old, and on farms with $100,000 or more of farm sales. Low ROPS prevalence rates were associated with farm operators 65 years old or older and with farms with less than $10,000 of farm product sales. Summary: The increase in ROPS prevalence between 1993 and 2004 has not been sufficient to decrease the rate of tractor overturn deaths on farms. Incentive programs targeting older farm operators and low-income farm operations are suggested to increase ROPS use on tractors. Impact on Industry: The study provides farm characteristics associated with low ROPS prevalence rates. The results can be used to target farms for future ROPS promotion activities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tractor overturns
KW - rollover protective structures
KW - interventions
KW - overturn deaths
KW - farm characteristics
KW - 2008
KW - Accidents
KW - Agricultural Workers
KW - Death and Dying
KW - Intervention
KW - 2008
DO - 10.1016/j.jsr.2008.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16696-010&site=ehost-live&scope=site
UR - JRMyers@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00434-002
AN - 2008-00434-002
AU - Broder, Karen R.
AU - Cohn, Amanda C.
AU - Schwartz, Benjamin
AU - Klein, Jonathan D.
AU - Fisher, Martin M.
AU - Fishbein, Daniel B.
AU - Mijalski, Christina
AU - Burstein, Gale R.
AU - Vernon-Smiley, Mary E.
AU - McCauley, Mary M.
AU - Wibbelsman, Charles J.
T1 - Adolescent immunizations and other clinical preventive services: A needle and a hook?
T3 - Strenghtening the delivery of new vaccines for adolescents
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/01//
VL - 121
IS - Suppl1
SP - S25
EP - S34
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Broder, Karen R., Office of the Chief Science Officer, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mail Stop D-26, Atlanta, GA, US, 30333
N1 - Accession Number: 2008-00434-002. Partial author list: First Author & Affiliation: Broder, Karen R.; National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20080211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Care Delivery; Health Care Services; Immunization. Minor Descriptor: Strategies. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). References Available: Y. Page Count: 10. Issue Publication Date: Jan, 2008.
AB - Advances in technology have led to development of new vaccines for adolescents, but these vaccines will be added to a crowded schedule of recommended adolescent clinical preventive services. We reviewed adolescent clinical preventive health care guidelines and patterns of adolescent clinical preventive service delivery and assessed how new adolescent vaccines might affect health care visits and the delivery of other clinical preventive services. Our analysis suggests that new adolescent immunization recommendations are likely to improve adolescent health, both as a 'needle' and a 'hook.' As a needle, the immunization will enhance an adolescent's health by preventing vaccine-preventable diseases during adolescence and adulthood. It also will likely be a hook to bring adolescents (and their parents) into the clinic for adolescent health care visits, during which other clinical preventive services can be provided. We also speculate that new adolescent immunization recommendations might increase the proportion and quality of other clinical preventive services delivered during health care visits. The factor most likely to diminish the positive influence of immunizations on delivery of other clinical preventive services is the additional visit time required for vaccine counseling and administration. Immunizations may 'crowd out' delivery of other clinical preventive services during visits or reduce the quality of the clinical preventive service delivery. Complementary strategies to mitigate these effects might include prioritizing clinical preventive services with a strong evidence base for effectiveness, spreading clinical preventive services out over several visits, and withholding selected clinical preventive services during a visit if the prevention activity is effectively covered at the community level. Studies are needed to evaluate the effect of new immunizations on adolescent preventive health care visits, delivery of clinical preventive services, and health outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent immunizations
KW - clinical preventive service delivery
KW - health
KW - clinical preventive health care visits
KW - strategies
KW - 2008
KW - Health
KW - Health Care Delivery
KW - Health Care Services
KW - Immunization
KW - Strategies
KW - 2008
DO - 10.1542/peds.2007-1115D
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00434-002&site=ehost-live&scope=site
UR - kbroder@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04477-003
AN - 2008-04477-003
AU - Du, Wenmin
AU - Guo, Jeff J.
AU - Jing, Yonghua
AU - Li, Xing
AU - Kelton, Christina M. L.
T1 - Drug safety surveillance in China and other countries: A review and comparison.
JF - Value in Health
JO - Value in Health
JA - Value Health
Y1 - 2008///
VL - 11
IS - Suppl 1
SP - S130
EP - S136
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1098-3015
SN - 1524-4733
AD - Guo, Jeff J., University of Cincinnati College of Pharmacy, 3225 Eden Ave., Cincinnati, OH, US, 45267-0004
N1 - Accession Number: 2008-04477-003. PMID: 18387057 Partial author list: First Author & Affiliation: Du, Wenmin; Shanghai Center for Adverse Drug Reaction Monitoring, Shanghai Food and Drug Administration, Shanghai, China. Other Publishers: Blackwell Publishing; Elsevier Science. Release Date: 20090413. Correction Date: 20120430. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Practice; Drug Laws; Pharmaceutical Industry; Public Health; Safety. Minor Descriptor: Food. Classification: Health & Mental Health Treatment & Prevention (3300). Methodology: Literature Review. References Available: Y. Page Count: 7. Issue Publication Date: 2008.
AB - Objectives: Drug safety and postmarketing surveillance have become important public health issues in China. This study reviews the relatively new drug safety surveillance system in China and compares it with the systems in the United States and Europe. Methods: An extensive literature review was conducted in the following four areas: 1) the organizational structure of the State Food and Drug Administration (SFDA) in China; 2) the development of an adverse drug reaction (ADR) monitoring system in China; 3) regulatory issues related to drug safety in China; and 4) similarities and differences between drug safety surveillance in China and surveillance in the United States and Europe. Results: The SFDA oversees an extensive network of drug safety 'watchdogs,' including the China National Center for ADR Monitoring and 32 regional centers throughout China. China's system has faced a number of recent challenges. It has had to respond quickly to the withdrawal of various high-profile drugs like Vioxx (rofecoxib) and Baycol (cerivastatin) from other markets. Together with China's Ministry of Health, the SFDA has faced several unique drug safety events. Three of those events, involving the injectable form of the heartleaf houttuyinia herb (Yu Xing Cao), Armillarisni A injections, and clindamycin glucose infusions (Xinfu), are discussed. The rapid development of drug safety surveillance in China is manifested in extensive organizational structure, development of large databases, and laws and regulations supporting drug safety. The two major laws are the China Drug Administration Law issued in February 2001 and the Regulation for the Administration of ADR Reporting and Monitoring issued in March 2004. The study also discusses and compares recent developments in drug safety surveillance in the United States and the European Union. These developments will most likely have implications for the Chinese system in the near future. Conclusions: While postmarketing surveillance guidelines are not yet available in China, we fully expect their eventual issuance after adaptation to the particular culture and clinical practices in China. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug safety surveillance
KW - culture practices
KW - clinical practices
KW - public health issues
KW - postmarketing surveillance
KW - 2008
KW - Clinical Practice
KW - Drug Laws
KW - Pharmaceutical Industry
KW - Public Health
KW - Safety
KW - Food
KW - 2008
DO - 10.1111/j.1524-4733.2008.00377.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04477-003&site=ehost-live&scope=site
UR - jeff.guo@uc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2008-19321-000
AN - 2008-19321-000
AU - Ali, Syed F.
AU - Kuhar, Michael J.
ED - Ali, Syed F.
ED - Kuhar, Michael J.
T1 - Drug addiction: Research frontiers and treatment advances.
T3 - Annals of the New York Academy of Sciences; Vol 1139; ISSN: 0077-8923 (Print)
Y1 - 2008///
VL - 1139
CY - Malden, MA, US
PB - Blackwell Publishers
SN - 0077-8923
SN - 1-57331-718-7
SN - 978-1-57331-718-4
N1 - Accession Number: 2008-19321-000. Partial author list: First Author & Affiliation: Ali, Syed F.; National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20091026. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 1-57331-718-7, Paperback; 978-1-57331-718-4, Paperback. Language: English. Conference Information: First Annual International Drug Abuse Research Society Meeting, Aug, Merida, Mexico. Conference Note: This volume is the result of the aforementioned conference and satellite meeting of the International Society for Neurochemistry, entided New Research Frontiers and Advances in Drug Addiction. Major Descriptor: Drug Addiction; Neurobiology; Treatment. Minor Descriptor: Experimentation; Neurochemistry. Classification: Substance Abuse & Addiction (3233); Neuropsychology & Neurology (2520). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). Page Count: 501.
AB - This volume contains a reviewed selection of papers presented at the First International Drug Abuse Research Society (IDARS) Meeting, a satellite meeting of the International Society for Neurochemistry (ISN). The major goal of the conference was to understand the cellular and molecular mechanisms of drugs of abuse, such as cocaine, substituted amphetamines (d-amphetamine, methamphetamine, and MDMA), marijuana, nicotine, GHB, and organic solvents. Separate sessions were devoted to the underlying mechanisms of drug addiction, such as genes and drugs of abuse; gene behavior and psychostimulants; substituted amphetamine neurotoxicity; oxidative stress, neurotoxicity, neurodegeneration, and neuroprotection; therapeutic approaches to drug addiction; similarities and differences between METH and MPTP-induced dopaminergic neurotoxicity; and nicotine, marijuana, alcohol, GHB, GBL, 1,4-BD, and dexmethorphan. Another feature of this conference was that each session included both clinical and basic research scientists working in the same area of research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug addiction
KW - therapeutic approaches
KW - treatment
KW - research
KW - cellular mechanisms
KW - molecular mechanisms
KW - 2008
KW - Drug Addiction
KW - Neurobiology
KW - Treatment
KW - Experimentation
KW - Neurochemistry
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-19321-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2008-07187-000
AN - 2008-07187-000
AU - Gullotta, Thomas P.
AU - Blau, Gary M.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
T1 - Family influences on childhood behavior and development: Evidence-based prevention and treatment approaches.
Y1 - 2008///
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-96532-3
N1 - Accession Number: 2008-07187-000. Partial author list: First Author & Affiliation: Gullotta, Thomas P.; Child and Family Agency, CT, US. Release Date: 20080721. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. ISBN: 978-0-415-96532-3, Hardcover. Language: English. Major Descriptor: Childhood Development; Evidence Based Practice; Family. Minor Descriptor: Coping Behavior; Distress; Intervention; Prevention; Resilience (Psychological); Treatment; Well Being. Classification: Developmental Psychology (2800); Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 342.
AB - Families provide the context in which children are raised and exposed to the larger world around them. Families clothe, bathe, and feed, and they create the environment in which children grow and develop. Families may be conventional or unconventional, biological or acquired, and are influenced by race, ethnicity, income, and education. Families teach about relationships and interactions with others, and they are part of neighborhoods, communities, and the world at large. This book is about families. It examines factors associated with families in distress, as well as factors that promote healthy coping skills and resilience. Distress may stem from the serious illness of a child or a parent, a reconfiguration of the family as in divorce and remarriage, or the harming of a family member sexually or physically. In this volume, the authors explore what family means today, what functions family serves, those circumstances that can make family life challenging or painful, and, most importantly, how prevention and treatment approaches can help. Grounded in recent research, this volume informs readers about appropriate interventions and how they can be implemented effectively. Readers will be able to apply these approaches to alleviate distress and promote well-being and resilience in families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family
KW - childhood behavior
KW - childhood development
KW - evidence-based prevention
KW - evidence-based treatment
KW - distress
KW - coping skills
KW - resilience
KW - interventions
KW - well-being
KW - 2008
KW - Childhood Development
KW - Evidence Based Practice
KW - Family
KW - Coping Behavior
KW - Distress
KW - Intervention
KW - Prevention
KW - Resilience (Psychological)
KW - Treatment
KW - Well Being
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07187-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2007-16458-000
AN - 2007-16458-000
AU - Gullotta, Thomas P.
AU - Blau, Gary M.
ED - Gullotta, Thomas P.
ED - Blau, Gary M.
T1 - Handbook of childhood behavioral issues: Evidence-based approaches to prevention and treatment.
Y1 - 2008///
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 0-415-95461-4
SN - 978-0-415-95461-7
N1 - Accession Number: 2007-16458-000. Partial author list: First Author & Affiliation: Gullotta, Thomas P.; Eastern Connecticut State University, CT, US. Release Date: 20080204. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Handbook/Manual. ISBN: 0-415-95461-4, Hardcover; 978-0-415-95461-7, Hardcover. Language: English. Major Descriptor: Behavior Problems; Childhood Development; Prevention; Treatment. Minor Descriptor: Mental Disorders; Mental Health. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 411.
AB - Recent years have seen increasing interest in the mental health field, particularly related to strategies that foster the positive behavior and healthy mental state of children. As the Handbook of Childhood Behavioral Issues indicates, however, the causes of childhood behavioral, physical, and mental health problems are multidimensional and cannot be treated with a uniform approach. Rather than focus solely on theory, this book offers evidence of effective interventions as well as extensive bio-psychosocial methods of preventative practices. The research confirms the impact that environment has on children and offers new approaches to address physical, mental health, and behavioral issues in children. This volume is broken down into chapters that concentrate on a specific behavior or disorder, which not only makes the information comprehensible, but also allows for in-depth coverage of a particular issue. In addition to considering the genetic and psychological factors that trigger childhood mental health problems, the handbook also investigates the significant impact that family members and the surrounding community have on a child's life. It is a book uniquely designed to include both the current perspectives on childhood development and the most effective treatment and prevention options. The result is a book that provides a deeper understanding of the variety of factors that contribute to a child's behavior, along with important information on the progress of evidence-based practices. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - childhood mental health problems
KW - childhood development
KW - behavioral issues
KW - evidence-based practices
KW - treatment
KW - prevention
KW - 2008
KW - Behavior Problems
KW - Childhood Development
KW - Prevention
KW - Treatment
KW - Mental Disorders
KW - Mental Health
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2007-16458-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2008-11975-000
AN - 2008-11975-000
AU - Stroul, Beth A.
AU - Blau, Gary M.
ED - Stroul, Beth A.
ED - Blau, Gary M.
T1 - The system of care handbook: Transforming mental health services for children, youth, and families.
Y1 - 2008///
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-962-7
SN - 978-1-55766-962-9
AD - Stroul, Beth A., Management & Training Innovations, Inc., 7417 Seneca Ridge Drive, Suite 100, McLean, VA, US, 22102
N1 - Accession Number: 2008-11975-000. Partial author list: First Author & Affiliation: Stroul, Beth A.; Management & Training Innovations, Inc., McLean, VA, US. Release Date: 20091116. Correction Date: 20160114. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Book Type: Handbook/Manual. ISBN: 1-55766-962-7, Hardcover; 978-1-55766-962-9, Hardcover. Language: English. Major Descriptor: Community Mental Health; Evidence Based Practice; Health Care Delivery; Mental Health Services. Minor Descriptor: Adolescent Psychology; Child Psychology; Competence; Decision Making; Mental Health; Sociocultural Factors; Health Care Reform. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100). Intended Audience: Psychology: Professional & Research (PS). Page Count: 726.
AB - For the past two decades, systems of care have been transforming services across America, and we are happy to report that the 'movement' to transform children's mental health services is alive and well. Historically, there have been calls for reform in children's mental health in the United States since the 1960's. The purpose of this handbook is to provide a compendium of information on how to develop systems of care—a one-stop reference for those interested in understanding and applying effective strategies for system-building and service delivery. Throughout the book, 'recommended practice' examples are incorporated, illustrating the implementation of critical elements of systems of care and offering a wealth of real-world experience. Evaluation results also are incorporated to illustrate the utilization of data to inform decision making at multiple levels, from providing services to individual children and families to system management. Key contextual issues and emerging trends affecting the development of systems of care are addressed, such as the current emphasis on implementing evidence-based practices. Core values and principles of systems of care such as individualized services, family and youth involvement, and cultural and linguistic competence serve as the foundation of the book and are incorporated into each chapter. Our intention is that the audience for this handbook will include the multiple constituencies that are involved in building community-based systems of care for children and their families across the nation's states and communities. It is designed to meet the burgeoning demand for written resources, tool kits, books, and other practical materials on the structures and processes involved in creating effective systems and services. This demand comes from the front lines including families, youth, program developers, and service delivery personnel, as well as from policy makers from partner child-serving agencies at federal, state, and local levels. Importantly, this book is also intended to fulfill requests from higher education institutions for materials appropriate for preservice education across the mental health disciplines that provide cutting-edge information on the development and maintenance of systems of care and state-of-the-art service delivery approaches. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children's mental health services
KW - service delivery
KW - decision making
KW - evidence-based practices
KW - cultural & linguistic competence
KW - community-based systems of care
KW - 2008
KW - Community Mental Health
KW - Evidence Based Practice
KW - Health Care Delivery
KW - Mental Health Services
KW - Adolescent Psychology
KW - Child Psychology
KW - Competence
KW - Decision Making
KW - Mental Health
KW - Sociocultural Factors
KW - Health Care Reform
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11975-000&site=ehost-live&scope=site
UR - bstroul@mtiworld.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Qu Yang, Mary
AU - Elnitski, Laura L.
T1 - Prediction-based approaches to characterize bidirectional promoters in the mammalian genome.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2008/01/02/2008 Supplement 1
VL - 9
M3 - Article
SP - 1
EP - 11
PB - BioMed Central
SN - 14712164
AB - Background: Machine learning approaches are emerging as a way to discriminate various classes of functional elements. Previous attempts to create Regulatory Potential (RP) scores to discriminate functional DNA from nonfunctional DNA included using Markov models trained to identify sequences from promoters and enhancers from ancestral repeats. We proposed that knowledge gleaned from those methods could be further refined using a multiple class predictor to separate classes of promoter elements from enhancers or nonfunctional DNA. Results: We extended our previous work, which identified over 5,000 candidate bidirectional promoters in the human genome, to map the orthologous promoter regions in the mouse genome. Our algorithm measured the robustness of evidence provided by the spliced EST annotations and incorporated evidence from annotations of UCSC Known Genes and GenBank mRNA. In preparation for de novo prediction of this promoter type, we examined characteristic features of the dataset as a whole. For instance, bidirectional promoters score very highly among all functional elements for Regulatory Potential Scores. This result was unexpected due to the limited sequence conservation found in these noncoding regions. We demonstrate that bidirectional promoters can be classified apart from other genomic features including non-bidirectional promoters, i.e. those promoters having no nearby upstream genes. Furthermore bidirectional promoters consistently score at the level of very highly conserved functional elements in the genome- developmental enhancers. The high scores are due to sequence-based characteristics within the promoters, not the surrounding exons. These results indicate that high-scoring RP regions can be deconvoluted into various functional classes of genomic elements. Using a multiple class predictor we are able to discriminate bidirectional promoters from enhancers, nonbidirectional promoters, and non-promoter regions on the basis of RP scores and CpG islands. Conclusions: We examine orthology at bidirectional promoters, use discriminatory machine learning approaches to differentiate multiple types of promoters from other functional and nonfunctional features in the genome and begin the process of deconvoluting classes of functional regions that score well with RP scores. These types of approaches precede supervised learning techniques to discover unannotated promoter regions. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACHINE learning
KW - GENOMES
KW - MAMMAL genetics
KW - PROMOTERS (Genetics)
KW - SUPERVISED learning (Machine learning)
N1 - Accession Number: 35701828; Qu Yang, Mary 1; Email Address: yangma@mail.nih.gov Elnitski, Laura L. 1; Email Address: elnitski@mail.nih.gov; Affiliation: 1: National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: 2008 Supplement 1, Vol. 9, Special section p1; Subject Term: MACHINE learning; Subject Term: GENOMES; Subject Term: MAMMAL genetics; Subject Term: PROMOTERS (Genetics); Subject Term: SUPERVISED learning (Machine learning); Number of Pages: 11p; Illustrations: 1 Diagram, 4 Charts, 6 Graphs; Document Type: Article
L3 - 10.1186/1471-2164-9-S1-S2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701828&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Yang, Jack Y.
AU - Qu Yang, Mary
AU - Zhu, Mengxia (Michelle)
AU - Arabnia, Hamid R.
AU - Youping Deng
T1 - Promoting synergistic research and education in genomics and bioinformatics.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2008/01/02/2008 Supplement 1
VL - 9
M3 - Proceeding
SP - 1
EP - 5
PB - BioMed Central
SN - 14712164
AB - Bioinformatics and Genomics are closely related disciplines that hold great promises for the advancement of research and development in complex biomedical systems, as well as public health, drug design, comparative genomics, personalized medicine and so on. Research and development in these two important areas are impacting the science and technology. High throughput sequencing and molecular imaging technologies marked the beginning of a new era for modern translational medicine and personalized healthcare. The impact of having the human sequence and personalized digital images in hand has also created tremendous demands of developing powerful supercomputing, statistical learning and artificial intelligence approaches to handle the massive bioinformatics and personalized healthcare data, which will obviously have a profound effect on how biomedical research will be conducted toward the improvement of human health and prolonging of human life in the future. The International Society of Intelligent Biological Medicine (http:// www.isibm.org) and its official journals, the International Journal of Functional Informatics and Personalized Medicine (http://www.inderscience.com/ijfipm) and the International Journal of Computational Biology and Drug Design (http:// www.inderscience.com/ijcbdd) in collaboration with International Conference on Bioinformatics and Computational Biology (Biocomp), touch tomorrow's bioinformatics and personalized medicine throughout today's efforts in promoting the research, education and awareness of the upcoming integrated inter/multidisciplinary field. The 2007 international conference on Bioinformatics and Computational Biology (BIOCOMP07) was held in Las Vegas, the United States of American on June 25-28, 2007. The conference attracted over 400 papers, covering broad research areas in the genomics, biomedicine and bioinformatics. The Biocomp 2007 provides a common platform for the cross fertilization of ideas, and to help shape knowledge and scientific achievements by bridging these two very important disciplines into an interactive and attractive forum. Keeping this objective in mind, Biocomp 2007 aims to promote interdisciplinary and multidisciplinary education and research. 25 high quality peer-reviewed papers were selected from 400+ submissions for this supplementary issue of BMC Genomics. Those papers contributed to a wide-range of important research fields including gene expression data analysis and applications, high-throughput genome mapping, sequence analysis, gene regulation, protein structure prediction, disease prediction by machine learning techniques, systems biology, database and biological software development. We always encourage participants submitting proposals for genomics sessions, special interest research sessions, workshops and tutorials to Professor Hamid R. Arabnia (hra@cs.uga.edu) in order to ensure that Biocomp continuously plays the leadership role in promoting inter/multidisciplinary research and education in the fields. Biocomp received top conference ranking with a high score of 0.95/1.00. Biocomp is academically cosponsored by the International Society of Intelligent Biological Medicine and the Research Laboratories and Centers of Harvard University -- Massachusetts Institute of Technology, Indiana University - Purdue University, Georgia Tech -- Emory University, UIUC, UCLA, Columbia University, University of Texas at Austin and University of Iowa etc. Biocomp - Worldcomp brings leading scientists together across the nation and all over the world and aims to promote synergistic components such as keynote lectures, special interest sessions, workshops and tutorials in response to the advances of cutting-edge research. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFERENCES & conventions
KW - BIOINFORMATICS
KW - GENOMICS -- Congresses
KW - COMPUTATIONAL biology
KW - CONGRESSES
KW - LAS Vegas (Nev.)
KW - NEVADA
N1 - Accession Number: 35701816; Yang, Jack Y. 1; Email Address: jyang@bwh.harvard.edu Qu Yang, Mary 2; Email Address: yangma@mail.nih.gov Zhu, Mengxia (Michelle) 3; Email Address: mzhu@cs.siu.edu Arabnia, Hamid R. 4; Email Address: hra@cs.uga.edu Youping Deng 5; Email Address: youping.deng@usm.edu; Affiliation: 1: Harvard University, PO Box 400888, Cambridge, Massachusetts 02140-0888, USA 2: National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20852, USA, 3: Southern Illinois University, Department of Computer Science, Carbondale, IL 62901, USA 4: University of Georgia, Department of Computer Science, Athens, GA 30602, USA 5: University of Southern Mississippi, Department of Biological Sciences, Hattiesberg, MS 39406, USA; Source Info: 2008 Supplement 1, Vol. 9, Special section p1; Subject Term: CONFERENCES & conventions; Subject Term: BIOINFORMATICS; Subject Term: GENOMICS -- Congresses; Subject Term: COMPUTATIONAL biology; Subject Term: CONGRESSES; Subject Term: LAS Vegas (Nev.); Subject Term: NEVADA; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Document Type: Proceeding
L3 - 10.1186/1471-2164-9-S1-I1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701816&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Funnell, Martha M.
AU - Brown, Tammy L.
AU - Childs, Belinda P.
AU - Haas, Linda B.
AU - Hosey, Gwen M.
AU - Jensen, Brian
AU - Maryniuk, Melinda
AU - Peyrot, Mark
AU - Piette, John D.
AU - Reader, Diane
AU - Siminerio, Linda M.
AU - Weinger, Katie
AU - Weiss, Michael A.
T1 - National Standards for Diabetes Self-Management Education.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2008/01/02/Jan2008 Supplement 1
VL - 31
M3 - Article
SP - S97
EP - S104
SN - 01495992
AB - This article explains that diabetes self-management education (DSME) is a critical element of care for all people with diabetes and is necessary in order to improve patient outcomes. The National Standards for DSME in the U.S. are designed to define quality diabetes self-management education and to assist diabetes educators in a variety of settings to provide evidence-based education. These standards are reviewed and revised every 5 years by key organizations and federal agencies within the diabetes education community.
KW - ENDOCRINE diseases
KW - DIABETES
KW - DIABETICS
KW - CLINICAL medicine
KW - THERAPEUTICS
KW - UNITED States
N1 - Accession Number: 28455796; Funnell, Martha M. 1 Brown, Tammy L. 2 Childs, Belinda P. 3 Haas, Linda B. 4 Hosey, Gwen M. 5 Jensen, Brian 6 Maryniuk, Melinda 7 Peyrot, Mark 8 Piette, John D. 9,10 Reader, Diane 10 Siminerio, Linda M. 11 Weinger, Katie 12 Weiss, Michael A. 13; Affiliation: 1: Department of Medical Education, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 2: Indian Health Service, Albuquerque, New Mexico 3: Mid-America Diabetes Associates, Wichita, Kansas 4: VA Puget Sound Health Care System, Seattle, Washington 5: Division of Diabetes Translation, National Center for Chronic Diseases Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 6: Lakeshore Apothacare, Two Rivers, Wisconsin 7: Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 8: Loyola College, Baltimore, Maryland 9: VA Ann Arbor Health Care System, Ann Arbor, Michigan 10: Department of Internal Medicine, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 11: International Diabetes Center, Minneapolis, Minnesota 12: Diabetes Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 13: Patient Centered Solutions, Pittsburgh, Pennsylvania; Source Info: Jan2008 Supplement 1, Vol. 31, pS97; Subject Term: ENDOCRINE diseases; Subject Term: DIABETES; Subject Term: DIABETICS; Subject Term: CLINICAL medicine; Subject Term: THERAPEUTICS; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article
L3 - 10.2337/dc08-S097
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28455796&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105714421
T1 - Orthopaedic joint devices: the FDA's short answers to your questions.
AU - Foy JR
AU - Buch BD
Y1 - 2008/01/02/2008 Suppl 1
N1 - Accession Number: 105714421. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2008 Suppl 1. Journal Subset: Allied Health; Biomedical; USA. Special Interest: Occupational Therapy; Perioperative Care; Physical Therapy; Sports Medicine. NLM UID: 9417468.
KW - Device Approval
KW - Joint Prosthesis
KW - Orthopedic Equipment and Supplies
KW - Prosthesis Design
KW - United States Food and Drug Administration
KW - Government Regulations
KW - Legislation, Medical
KW - Product Labeling
KW - United States
SP - S123
EP - 8
JO - Journal of the American Academy of Orthopaedic Surgeons
JF - Journal of the American Academy of Orthopaedic Surgeons
JA - J AM ACAD ORTHOP SURG
VL - 16
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1067-151X
AD - Orthopaedic Joint Devices Branch, Division of General, Restorative and Neurological Devices, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD, USA.
U2 - PMID: 18612007.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105714421&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ortega-Sanchez, Ismael R.
AU - Lee, Grace M.
AU - Jacobs, R. Jake
AU - Prosser, Lisa A.
AU - Molinari, Noelle-Angelique
AU - Xinzhi Zhang
AU - Baine, William B.
AU - McCauley, Mary M.
AU - Miller, Ted
T1 - Projected Cost-effectiveness of New Vaccines for Adolescents in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/01/02/Jan2008 Supplement 1
VL - 121
M3 - Article
SP - 563
EP - 578
SN - 00314005
AB - BACKGROUND. Economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. However, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood. OBJECTIVE. Our goal was to examine economic studies of adolescent vaccines and compare cost-effectiveness outcomes among studies on a particular vaccine, across adolescent vaccines, and between new adolescent vaccines versus vaccines that are recommended for young children. METHODS. A systematic review of economic studies on immunizations for adolescents was conducted. Studies were identified by searching the Medline, Embase, and EconLit databases. Each study was reviewed for appropriateness of model design, baseline setup, sensitivity analyses, and input variables (ie, epidemiologic, clinical, cost, and quality-of-life impact). For comparison, the cost-effectiveness outcomes reported in key studies on vaccines for younger children were selected. RESULTS. Vaccines for healthy adolescents were consistently found to be more costly than the health care or societal cost savings they produced and, in general, were less cost-effective than vaccines for younger children. Among the new vaccines, pertussis and human papillomavirus vaccines were more cost-effective than meningococcal vaccines. Including herd-immunity benefits in studies significantly improved the cost-effectiveness estimates for new vaccines. Differences in measurements or assumptions limited further comparisons. CONCLUSION. Although using the new adolescent vaccines is unlikely to be cost-saving, vaccination programs will result in sizable health benefits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNIZATION
KW - VACCINES
KW - MEDICAL care costs
KW - CHILDREN -- Health
KW - VACCINATION
KW - PAPILLOMAVIRUS diseases
KW - adolescents
KW - cost-effectiveness
KW - vaccines
N1 - Accession Number: 28350433; Ortega-Sanchez, Ismael R. 1; Email Address: iortegasanchez@cdc.gov Lee, Grace M. 2,3 Jacobs, R. Jake 4 Prosser, Lisa A. 2 Molinari, Noelle-Angelique 1 Xinzhi Zhang 5 Baine, William B. 6 McCauley, Mary M. 1 Miller, Ted 7; Affiliation: 1: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts 3: Division of Infectious Diseases, Children's Hospital Boston, Boston, Massachusetts 4: Capitol Outcomes Research, Inc, Alexandria, Virginia 5: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 6: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland 7: Pacific Institute for Research and Evaluation, Calverton, Maryland; Source Info: Jan2008 Supplement 1, Vol. 121, p563; Subject Term: IMMUNIZATION; Subject Term: VACCINES; Subject Term: MEDICAL care costs; Subject Term: CHILDREN -- Health; Subject Term: VACCINATION; Subject Term: PAPILLOMAVIRUS diseases; Author-Supplied Keyword: adolescents; Author-Supplied Keyword: cost-effectiveness; Author-Supplied Keyword: vaccines; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 16p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2007-1115H
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28350433&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thoroughman, Doug
T1 - Applied Epidemiology Competencies: Experience in the Field.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/01/02/Jan/Feb2008 Supplement
VL - 123
M3 - Article
SP - 8
EP - 10
SN - 00333549
AB - The article focuses on the development of the Competencies for Applied Epidemiologists in Governmental Public Health Agencies (AECs) by the U.S. Centers for Disease Control and Prevention (CDC) and the Council of State and Territorial Epidemiologists (CSTE). Accordingly, there are difficulties in attracting and retaining trained epidemiologists in some states like Kentucky. However, it says that the use of AECs is intended to assess and guide the medical personnel to target gaps in their own abilities and training.
KW - EPIDEMIOLOGISTS
KW - PUBLIC health personnel -- Training of
KW - ABILITY testing
KW - EMPLOYEE retention
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 31143998; Thoroughman, Doug 1; Email Address: douglas.thoroughman@ky.gov; Affiliation: 1: CDR U.S. Public Health Service, Kentucky Department for Public Health, Division of Epidemiology and Health Planning, Frankfort, KY; Source Info: Jan/Feb2008 Supplement, Vol. 123, p8; Subject Term: EPIDEMIOLOGISTS; Subject Term: PUBLIC health personnel -- Training of; Subject Term: ABILITY testing; Subject Term: EMPLOYEE retention; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105743430
T1 - Applied epidemiology competencies: experience in the field.
AU - Thoroughman D
Y1 - 2008/01/02/Jan/Feb2008 Supplement
N1 - Accession Number: 105743430. Language: English. Entry Date: 20080620. Revision Date: 20150711. Publication Type: Journal Article; anecdote. Supplement Title: Jan/Feb2008 Supplement. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Epidemiology -- Education
KW - Health Personnel -- Education
KW - Professional Competence
KW - Public Health Administration
KW - Career Planning and Development
KW - Centers for Disease Control and Prevention (U.S.)
KW - Education, Continuing
KW - Kentucky
KW - United States
SP - 8
EP - 10
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 123
PB - Sage Publications Inc.
SN - 0033-3549
AD - U.S. Public Health Service, Kentucky Department for Public Health, Division of Epidemiology and Health Planning, 275 E. Main St., HS 2GW-C, Frankfort, KY 40621; douglas.thoroughman@ky.gov
U2 - PMID: 18497011.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105467047
T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry.
AU - McKernan LT
AU - Ruder AM
AU - Petersen MR
AU - Hein MJ
AU - Forrester CL
AU - Sanderson WT
AU - Ashley DL
AU - Butler MA
Y1 - 2008/01/03/2008 Supplement 2
N1 - Accession Number: 105467047. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: 2008 Supplement 2. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 101147645.
KW - Hydrocarbons, Chlorinated -- Analysis
KW - Industry
KW - Occupational Exposure -- Analysis
KW - Adult
KW - Aged
KW - Body Mass Index
KW - Breath Tests
KW - Environmental Monitoring -- Methods
KW - Female
KW - Hydrocarbons, Chlorinated -- Blood
KW - Hydrocarbons, Chlorinated -- Urine
KW - Middle Age
KW - Pilot Studies
KW - Regression
KW - Solvents -- Analysis
KW - Human
SP - 12
EP - 12
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
JA - ENVIRON HEALTH
VL - 7
PB - BioMed Central
SN - 1476-069X
AD - Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA. LTaylor@cdc.gov
U2 - PMID: 18412959.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tice, Jeffrey A.
AU - Hoffman, Richard M.
AU - Steiner, Claudia
AU - Feldman, Mitchell D.
T1 - Introduction.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2008/01/03/Jan2008 Supplement 1
VL - 23
IS - S1
M3 - Article
SP - 1
EP - 1
SN - 08848734
AB - The article discusses various reports published within the issue including one that describes the tremendous potential of the biotechnology revolution to improve cancer screening through proteomics and another about the issues of Food and Drug Administration regulation and technology assessment.
KW - MOLECULAR biology
KW - MEDICAL policy
N1 - Accession Number: 32486437; Tice, Jeffrey A. 1; Email Address: jtice@medicine.ucsf.edu Hoffman, Richard M. 2,3 Steiner, Claudia 4 Feldman, Mitchell D. 1; Affiliation: 1: Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA 2: Department of Medicine, University of New Mexico, Albuquerque, NM, USA 3: Medicine Service, New Mexico VA Health Care System, Albuquerque, NM, USA 4: Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Jan2008 Supplement 1, Vol. 23 Issue S1, p1; Subject Term: MOLECULAR biology; Subject Term: MEDICAL policy; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Article
L3 - 10.1007/s11606-007-0458-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chunliu Zhan
AU - Baine, William B.
AU - Sedrakyan, Artyom
AU - Steiner, Claudia
T1 - Cardiac Device Implantation in the United States from 1997 through 2004: A Population-based Analysis.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2008/01/03/Jan2008 Supplement 1
VL - 23
IS - S1
M3 - Article
SP - 13
EP - 19
SN - 08848734
AB - Use of cardiac devices has been increasing rapidly along with concerns over their safety and effectiveness. This study used hospital administrative data to assess cardiac device implantations in the United States, selected perioperative outcomes, and associated patient and hospital characteristics. We screened hospital discharge abstracts from the 1997–2004 Healthcare Cost and Utilization Project Nationwide Inpatient Samples. Patients who underwent implantation of pacemaker (PM), automatic cardioverter/defibrillator (AICD), or cardiac resynchronization therapy pacemaker (CRT-P) or defibrillator (CRT-D) were identified using ICD-9-CM procedure codes. Outcomes ascertainable from these data and associated hospital and patient characteristics were analyzed. Approximately 67,000 AICDs and 178,000 PMs were implanted in 2004 in the United States, increasing 60% and 19%, respectively, since 1997. After FDA approval in 2001, CRT-D and CRT-P reached 33,000 and 7,000 units per year in the United States in 2004. About 70% of the patients were aged 65 years or older, and more than 75% of the patients had 1 or more comorbid diseases. There were substantial decreases in length of stay, but marked increases in charges, for example, the length of stay of AICD implantations halved (from 9.9 days in 1997 to 5.2 days in 2004), whereas charges nearly doubled (from $66,000 in 1997 to $117,000 in 2004). Rates of in-hospital mortality and complications fluctuated slightly during the period. Overall, adverse outcomes were associated with advanced age, comorbid conditions, and emergency admissions, and there was no consistent volume–outcome relationship across different outcome measures and patient groups. The numbers of cardiac device implantations in the United States steadily increased from 1997 to 2004, with substantial reductions in length of stay and increases in charges. Rates of in-hospital mortality and complications changed slightly over the years and were associated primarily with patient frailty. [ABSTRACT FROM AUTHOR]
AB - Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MEDICAL care
KW - OUTCOME assessment (Medical care)
KW - MEDICAL equipment
KW - MEDICAL economics
KW - UNITED States
KW - administrative data
KW - cardiac resynchronization therapy
KW - ICD-9-CM
KW - implantable cardioverter-defibrillator
KW - pacemaker
N1 - Accession Number: 32486434; Chunliu Zhan 1; Email Address: chunliu.zhan@ahrq.hhs.gov Baine, William B. 1 Sedrakyan, Artyom 1 Steiner, Claudia 2; Affiliation: 1: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA 2: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Jan2008 Supplement 1, Vol. 23 Issue S1, p13; Subject Term: MEDICAL care costs; Subject Term: MEDICAL care; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL equipment; Subject Term: MEDICAL economics; Subject Term: UNITED States; Author-Supplied Keyword: administrative data; Author-Supplied Keyword: cardiac resynchronization therapy; Author-Supplied Keyword: ICD-9-CM; Author-Supplied Keyword: implantable cardioverter-defibrillator; Author-Supplied Keyword: pacemaker; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 7p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1007/s11606-007-0392-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105776986
T1 - Review of current U.S. Army dental emergency rates.
AU - Chaffin J
AU - Moss D
Y1 - 2008/01/03/2008 Jan Supplement
N1 - Accession Number: 105776986. Language: English. Entry Date: 20080801. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2008 Jan Supplement. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. NLM UID: 2984771R.
KW - Dental Care
KW - Military Dentistry
KW - Military Personnel
KW - Tooth Diseases -- Epidemiology
KW - Emergencies -- Epidemiology
KW - Iraq
KW - Literature Review
KW - United States -- Epidemiology
SP - 23
EP - 26
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 173
IS - 1
CY - Bethesda, Maryland
PB - AMSUS
AB - The purpose of this article was to review current dental emergency rates for U.S. Army personnel and to identify shortfalls in dental emergency research. The Department of Defense Dental Classification System is intended to identify military personnel at the greatest risk for dental emergencies, allowing military dental assets to prioritize dental treatment. Only two studies have been published on the emergency rates of U.S. Army Soldiers since 2000, both detailing emergency rates for Soldiers deployed to Bosnia. The Stabilization Force VII study identified that Soldiers experienced dental emergencies at a rate of 156 per 1000 per year, whereas the Stabilization Force VIII study found the rate of 170 per 1000 per year. No studies have been conducted for the Army during Operation Iraqi Freedom due to difficulty in capturing all dental treatment encounters. Researchers should attempt to standardize the nomenclature and definitions to aid in the comparability of future dental emergency rate studies.
SN - 0026-4075
AD - Public Health Dental Officer, Office of the Surgeon General, Department of the Army, DASG-DC; 5109 Leesburg Pike, Suite 682, Falls Church, VA 22041
U2 - PMID: 18277718.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thomas W. S. Pang
AU - Martin Harper
T1 - The quality of fiber counts using improved slides with relocatable fields.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/01/04/
VL - 10
IS - 1
M3 - Article
SP - 89
EP - 95
SN - 14640325
AB - A parameter based on discrepancies between reported fibers and verified fibers of relocatable slides is shown to be effective in monitoring the quality of airborne fiber counts. Analysts report only the fibers in each field examined. The verified fibers were determined by two experienced analysts, and are here considered as a “true” value. Most of the verified fibers were confirmed by the reported fibers, and the disputed fibers or fiber counting errors were all located and accounted for. In this study, reference (REF) slides were manufactured from proficiency analytical test (PAT) filter samples from the American Industrial Hygiene Association containing chrysotile or amosite. The slides were made using coverglasses bearing a grid pattern to allow accurate re-examinations. These coverglasses are an improved version of those used in previous studies. Seventy-four out of 85 amosite results and 51 out of 60 chrysotile results of REF slides were within their PAT proficiency ranges. When all reported fibers were normalized against their respective verified fibers, the average fiber count was over-estimated for amosite by 38.3% and under-estimated for chrysotile by 30.4%. The error from counting short fibers (sizing-extra) was 82.6% of the extra fibers and accounted for the 38% over-estimation of amosite fibers. For chrysotile fibers, sizing-extra errors were 74.0% of the extra fibers, but by far the larger errors were oversight-missing errors, which were 96.7% of the missing fibers and accounted for the 30% under-estimation of the chrysotile fibers. The discrepancies were found to be linearly related to counting errors as had been noted in a previous study, giving further weight to a proposed score, calculated from the discrepancy parameter (∑D+ + |∑D–|)/VFtotal, for evaluating the proficiencies of analysts. If a proficiency score = 60 is selected, 48 out of 85 amosite results and 17 out of 60 chrysotile results satisfied this criterion in this study. The number of fiber counting errors in this study was larger than could be expected by PAT proficiency criteria. It may be useful to complement existing proficiency test programs with these REF slides. At the end of each proficiency testing round, detailed reports of discrepancies can be provided to participants so that they can improve on their skills in searching and sizing fibers and minimize their counting errors. In addition, the internal quality control program of each laboratory could include counting REF slides regularly by all analysts with control charts of (∑D+/VFtotal), (∑D–/VFtotal), (∑D+ + |∑D–|)/VFtotal and RFtotal/VFtotal maintained to monitor errors, proficiencies and intercounter variations. Ten percent of relocatable slides of routine samples could also be recounted to monitor intracounter variation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fibers
KW - Associations, institutions, etc.
KW - Chrysotile
KW - Serpentine
N1 - Accession Number: 28331522; Thomas W. S. Pang 1; Martin Harper 2; Affiliations: 1: Ryerson University, School of Public and Occupational HealthRoom 249A350, Victoria St. Toronto, ON Canada; 2: National Institute for Occupational Safety and Health, Exposure Assessment Branch, Health Effects Laboratory Division1095 Willowdale Rd. MS-3030 Morgantown USA; Issue Info: Jan2008, Vol. 10 Issue 1, p89; Subject Term: Fibers; Subject Term: Associations, institutions, etc.; Subject Term: Chrysotile; Subject Term: Serpentine; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212311 Dimension Stone Mining and Quarrying; NAICS/Industry Codes: 212316 Marble mining and quarrying; NAICS/Industry Codes: 212319 Other Crushed and Broken Stone Mining and Quarrying; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Steven J. Page
AU - Jon C. Volkwein
AU - Robert P. Vinson
AU - Gerald J. Joy
AU - Steven E. Mischler
AU - Donald P. Tuchman
AU - Linda J. McWilliams
T1 - Equivalency of a personal dust monitor to the current United States coal mine respirable dust sampler.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/01/04/
VL - 10
IS - 1
M3 - Article
SP - 96
EP - 101
SN - 14640325
AB - The United States National Institute for Occupational Safety and Health, through an informal partnership with industry, labor, and the United States Mine Safety and Health Administration, has developed and tested a new instrument known as the Personal Dust Monitor (PDM). The new dust monitor is an integral part of the cap lamp that coal miners normally carry to work and provides continuous information about the concentration of respirable coal mine dust within the breathing zone of that individual. Previous laboratory testing demonstrated that there is a 95% confidence that greater than 95% of individual PDM measurements fall within ± 25% of reference measurements. The work presented in this paper focuses on the relationship between the PDM and respirable dust concentrations currently measured by a coal mine dust personal sampler unit utilizing a 10 mm Dorr–Oliver nylon cyclone. The United Kingdom Mining Research Establishment instrument, used as the basis for coal mine respirable dust standards, had been designed specifically to match the United Kingdom British Medical Research Council (BMRC) criterion. The personal sampler is used with a 1.38 multiplier to convert readings to the BMRC criterion. A stratified random sampling design incorporating a proportionate allocation strategy was used to select a sample of mechanized mining units representative of all US underground coal mines. A sample of 180 mechanized mining units was chosen, representing approximately 20% of the mechanized mining units in production at the time the sample was selected. A total of 129 valid PDM/personal sampler dust sample sets were obtained. A weighted linear regression analysis of this data base shows that, in comparison with the personal sampler, the PDM requires a mass equivalency conversion multiplier of 1.05 [95% C.I. = (1.03, 1.08)] when the small intercept term is removed from the analysis. Removal of the intercept term results in a personal sampler-equivalent concentration increase of 2.9% at a PDM measurement of 2.0 mg m–3. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Coal mines & mining
KW - Coal industry
KW - Industrial safety
KW - System safety
N1 - Accession Number: 28331526; Steven J. Page 1; Jon C. Volkwein 1; Robert P. Vinson 1; Gerald J. Joy 1; Steven E. Mischler 1; Donald P. Tuchman 1; Linda J. McWilliams 1; Affiliations: 1: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and HealthPittsburgh Research Laboratory, 626 Cochrans Mill Road Pittsburgh USA; Issue Info: Jan2008, Vol. 10 Issue 1, p96; Thesaurus Term: Coal mines & mining; Thesaurus Term: Coal industry; Thesaurus Term: Industrial safety; Subject Term: System safety; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 454310 Fuel Dealers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gergely, R. M.
AU - Hokel, B. W.
AU - Calvert, G. M.
AU - Luckhaupt, S. E.
T1 - Acute Pesticide Poisoning Associated with Pyraclostrobin Fungicide -- Iowa, 2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/01/04/
VL - 56
IS - 51/52
M3 - Article
SP - 1343
EP - 1345
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article describes five events of acute pesticide poisoning with pyraclostrobin in Iowa in 2007. Pyraclostrobin is an agricultural pesticide used to kill fungi but is harmful to human. In July, the Iowa Department of Helth (IDOH) received five reports of pyraclostrobin exposure across that state which sickened several people. Upon investigation, IDOH identified pyraclostrobin on-site. The article offers ideas on preventing additional illnesses associated with pyraclostrobin exposure.
KW - PESTICIDES -- Physiological effect
KW - POISONING
KW - AGRICULTURAL chemicals
KW - FUNGICIDES
KW - IOWA
N1 - Accession Number: 28142740; Gergely, R. M. 1 Hokel, B. W. 1 Calvert, G. M. 2 Luckhaupt, S. E. 3; Affiliation: 1: Dept of Public Health, Iowa 2: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health 3: EIS Officer, CDC; Source Info: 2008, Vol. 56 Issue 51/52, p1343; Subject Term: PESTICIDES -- Physiological effect; Subject Term: POISONING; Subject Term: AGRICULTURAL chemicals; Subject Term: FUNGICIDES; Subject Term: IOWA; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Peden, Keith
AU - Sheng, Li
AU - Omeir, Romelda
AU - Yacobucci, Maureen
AU - Klutch, Michael
AU - Laassri, Majid
AU - Chumakov, Konstantin
AU - Pal, Achintya
AU - Murata, Haruhiko
AU - Lewis, Andrew M.
T1 - Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960s
JO - Virology
JF - Virology
Y1 - 2008/01/05/
VL - 370
IS - 1
M3 - Article
SP - 63
EP - 76
SN - 00426822
AB - Abstract: From stocks of adenovirus and poliovirus prepared in primary rhesus macaque kidney cells and dating from 1956 to 1961, the time when SV40 contaminated some poliovirus vaccine lots, we have recovered ten isolates of SV40. Of these ten isolates, based on the C-terminal region of T antigen, five novel strains of SV40 have been identified. Additionally, three pairs of isolates were found to be the same strain: one pair was strain 777, one pair was strain 776 archetype, and the third pair represented a novel strain. All strains had identical protein sequences for VP2 and VP3. There were two variants of agnoprotein and the small t antigen and three variants of VP1. These results, and those of others, suggest that a limited number of SV40 strains might exist in rhesus macaques in the United States, and thus determining the origin of the SV40 sequences detected in human tumors might be difficult. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYOMAVIRUSES
KW - RHESUS monkey
KW - ADENOVIRUSES
KW - AMINO acid sequence
KW - Monkey kidney cells
KW - Polyomavirus
KW - Sequencing
KW - Strain
KW - Virus isolation
N1 - Accession Number: 27722255; Peden, Keith 1; Email Address: keith.peden@fda.hhs.gov Sheng, Li 1 Omeir, Romelda 1 Yacobucci, Maureen 1 Klutch, Michael 2 Laassri, Majid 3 Chumakov, Konstantin 3 Pal, Achintya 2 Murata, Haruhiko 1,2 Lewis, Andrew M. 2; Affiliation: 1: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29A, Room 3D08, 29 Lincoln Drive, Bethesda, MD 20892, USA 2: Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Laboratory of Methods Development, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jan2008, Vol. 370 Issue 1, p63; Subject Term: POLYOMAVIRUSES; Subject Term: RHESUS monkey; Subject Term: ADENOVIRUSES; Subject Term: AMINO acid sequence; Author-Supplied Keyword: Monkey kidney cells; Author-Supplied Keyword: Polyomavirus; Author-Supplied Keyword: Sequencing; Author-Supplied Keyword: Strain; Author-Supplied Keyword: Virus isolation; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.virol.2007.06.045
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gupta, Abhay
AU - Ciavarella, Anthony B.
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
AU - Faustino, Patrick J.
T1 - Development and application of a validated HPLC method for the analysis of dissolution samples of gabapentin drug products
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/01/07/
VL - 46
IS - 1
M3 - Article
SP - 181
EP - 186
SN - 07317085
AB - Abstract: A simple isocratic reversed-phase HPLC method was developed and validated for the analysis of dissolution samples of gabapentin tablets and capsules. Separation of gabapentin from its major degradation impurity, 3,3-pentamethylene-4-butyrolactam was achieved on a Phenomenex Luna Cyano column using a methanol–acetonitrile–20mM KH2PO4 (pH 2.2) (5:5:90, v/v/v) mobile phase. The compounds were eluted isocratically at a flow rate of 1.25mL/min. Both compounds were analyzed with UV detection at 210nm. The method was validated according to USP Category I requirements for gabapentin. The validation characteristics included accuracy, precision, linearity, range, specificity and limit of quantitation. Robustness testing was also conducted to evaluate the effect of minor changes to the chromatographic system and to establish appropriate system suitability parameters. Validation acceptance criteria were met in all cases. This method was used successfully for the quality assessment of five gabapentin drug products. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOLOGY
KW - DRUGS
KW - DRUGS -- Physiological effect
KW - CHROMATOGRAPHIC analysis
KW - Dissolution
KW - Drug products
KW - Gabapentin
KW - HPLC
KW - Impurity
KW - Lactam
N1 - Accession Number: 27854283; Gupta, Abhay 1 Ciavarella, Anthony B. 1 Sayeed, Vilayat A. 2 Khan, Mansoor A. 1 Faustino, Patrick J. 1; Email Address: patrick.faustino@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, Life Science Building 64, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Office of Generic Drugs, Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Jan2008, Vol. 46 Issue 1, p181; Subject Term: PHARMACOLOGY; Subject Term: DRUGS; Subject Term: DRUGS -- Physiological effect; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Drug products; Author-Supplied Keyword: Gabapentin; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Impurity; Author-Supplied Keyword: Lactam; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2007.08.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27854283&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Huixiao Hong
AU - Zhenqiang Su
AU - Weigong Ge
AU - Leming Shi
AU - Perkins, Roger
AU - Hong Fang
AU - Xu, Joshua
AU - Chen, James J.
AU - Tao Han
AU - Kaput, Jim
AU - Fuscoe, James C.
AU - Tong, Weida
T1 - Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2008/01/10/2008 Supplement 9
VL - 9
M3 - Article
SP - 1
EP - 13
PB - BioMed Central
SN - 14712105
AB - Background: Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as disease status and drug response. Highly accurate and reproducible genotype calling are paramount since errors introduced by calling algorithms can lead to inflation of false associations between genotype and phenotype. Most genotype calling algorithms currently used for GWAS are based on multiple arrays. Because hundreds of gigabytes (GB) of raw data are generated from a GWAS, the samples are typically partitioned into batches containing subsets of the entire dataset for genotype calling. High call rates and accuracies have been achieved. However, the effects of batch size (i.e., number of chips analyzed together) and of batch composition (i.e., the choice of chips in a batch) on call rate and accuracy as well as the propagation of the effects into significantly associated SNPs identified have not been investigated. In this paper, we analyzed both the batch size and batch composition for effects on the genotype calling algorithm BRLMM using raw data of 270 HapMap samples analyzed with the Affymetrix Human Mapping 500 K array set. Results: Using data from 270 HapMap samples interrogated with the Affymetrix Human Mapping 500 K array set, three different batch sizes and three different batch compositions were used for genotyping using the BRLMM algorithm. Comparative analysis of the calling results and the corresponding lists of significant SNPs identified through association analysis revealed that both batch size and composition affected genotype calling results and significantly associated SNPs. Batch size and batch composition effects were more severe on samples and SNPs with lower call rates than ones with higher call rates, and on heterozygous genotype calls compared to homozygous genotype calls. Conclusion: Batch size and composition affect the genotype calling results in GWAS using BRLMM. The larger the differences in batch sizes, the larger the effect. The more homogenous the samples in the batches, the more consistent the genotype calls. The inconsistency propagates to the lists of significantly associated SNPs identified in downstream association analysis. Thus, uniform and large batch sizes should be used to make genotype calls for GWAS. In addition, samples of high homogeneity should be placed into the same batch. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENOMES
KW - COMPUTER algorithms
KW - HUMAN gene mapping
KW - HUMAN genome
KW - GENETICS
KW - GENOTYPE-environment interaction
KW - PHENOTYPE
KW - GENETIC polymorphisms
N1 - Accession Number: 35701341; Huixiao Hong 1; Email Address: Huixiao.Hong@fda.hhs.gov Zhenqiang Su 1; Email Address: Zhenqiang.Su@fda.hhs.gov Weigong Ge 1; Email Address: Weigong.Ge@fda.hhs.gov Leming Shi 1; Email Address: Leming.Shi@fda.hhs.gov Perkins, Roger 2; Email Address: Roger.Perkins@fda.hhs.gov Hong Fang 2; Email Address: Hong.Fang@fda.hhs.gov Xu, Joshua 2; Email Address: Joshua.Xu@fda.hhs.gov Chen, James J. 3; Email Address: JamesJ.Chen@fda.hhs.gov Tao Han 1; Email Address: Tao.Han@fda.hhs.gov Kaput, Jim 3; Email Address: James.Kaput@fda.hhs.gov Fuscoe, James C. 1; Email Address: James.Fuscoe@fda.hhs.gov Tong, Weida 1; Email Address: Weida.Tong@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Z-Tech Corp, an ICF International Company at National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: 2008 Supplement 9, Vol. 9, Special section p1; Subject Term: GENOMES; Subject Term: COMPUTER algorithms; Subject Term: HUMAN gene mapping; Subject Term: HUMAN genome; Subject Term: GENETICS; Subject Term: GENOTYPE-environment interaction; Subject Term: PHENOTYPE; Subject Term: GENETIC polymorphisms; Number of Pages: 13p; Illustrations: 2 Diagrams, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-9-S9-S17
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701341&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leming Shi
AU - Jones, Wendell D.
AU - Jensen, Roderick V.
AU - Harris, Stephen C.
AU - Perkins, Roger G.
AU - Goodsaid, Federico M.
AU - Lei Guo
AU - Croner, Lisa J.
AU - Boysen, Cecilie
AU - Hong Fang
AU - Feng Qian
AU - Amur, Shashi
AU - Wenjun Bao
AU - Barbacioru, Catalin C.
AU - Bertholet, Vincent
AU - Cao, Xiaoxi Megan
AU - Tzu-Ming Chu
AU - Collins, Patrick J.
AU - Xiao-hui Fan
AU - Frueh, Felix W.
T1 - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2008/01/10/2008 Supplement 9
VL - 9
M3 - Article
SP - 1
EP - 19
PB - BioMed Central
SN - 14712105
AB - Background: Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) are not reproducible in similar experiments. Meanwhile, new statistical methods for identifying DEGs continue to appear in the scientific literature. The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists. Results: Using the data sets generated by the MicroArray Quality Control (MAQC) project, we investigated the impact on the reproducibility of DEG lists of a few widely used gene selection procedures. We present comprehensive results from inter-site comparisons using the same microarray platform, cross-platform comparisons using multiple microarray platforms, and comparisons between microarray results and those from TaqMan -- the widely regarded "standard" gene expression platform. Our results demonstrate that (1) previously reported discordance between DEG lists could simply result from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion with a non-stringent P-value cutoff filtering, the DEG lists become much more reproducible, especially when fewer genes are selected as differentially expressed, as is the case in most microarray studies; and (3) the instability of short DEG lists solely based on P-value ranking is an expected mathematical consequence of the high variability of the t-values; the more stringent the P-value threshold, the less reproducible the DEG list is. These observations are also consistent with results from extensive simulation calculations. Conclusion: We recommend the use of FC-ranking plus a non-stringent P cutoff as a straightforward and baseline practice in order to generate more reproducible DEG lists. Specifically, the P-value cutoff should not be stringent (too small) and FC should be as large as possible. Our results provide practical guidance to choose the appropriate FC and P-value cutoffs when selecting a given number of DEGs. The FC criterion enhances reproducibility, whereas the P criterion balances sensitivity and specificity. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - DNA microarrays
KW - GENE expression
KW - STATISTICAL significance
KW - T-test (Statistics)
N1 - Accession Number: 35701334; Leming Shi 1; Email Address: leming.shi@fda.hhs.gov Jones, Wendell D. 2; Email Address: wjones@expressionanalysis.com Jensen, Roderick V. 3; Email Address: rvjensen@vt.edu Harris, Stephen C. 1; Email Address: stephen.harris@fda.hhs.gov Perkins, Roger G. 4; Email Address: roger.perkins@fda.hhs.gov Goodsaid, Federico M. 5; Email Address: federico.goodsaid@fda.hhs.gov Lei Guo 1; Email Address: lei.guo@fda.hhs.gov Croner, Lisa J. 6; Email Address: lisa.croner@biogenidec.com Boysen, Cecilie 7; Email Address: cecilie.boysen@vialogy.com Hong Fang 4; Email Address: hong.fang@fda.hhs.gov Feng Qian 4; Email Address: feng.qian@fda.hhs.gov Amur, Shashi 5; Email Address: shashi.amur@fda.hhs.gov Wenjun Bao 8; Email Address: wenjun.bao@sas.com Barbacioru, Catalin C. 9; Email Address: catalin.barbacioru@appliedbiosystems.com Bertholet, Vincent 10; Email Address: bertholet.v@eppendorf.be Cao, Xiaoxi Megan 4; Email Address: xiaoxicao@gmail.com Tzu-Ming Chu 8; Email Address: tzu-ming.chu@sas.com Collins, Patrick J. 11; Email Address: jim_collins@affymetrix.com Xiao-hui Fan 1,12; Email Address: xiao-hui.fan@fda.hhs.gov Frueh, Felix W. 5; Email Address: felix@genpad.com; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Expression Analysis Inc., 2605 Meridian Parkway, Durham, NC 27713, USA 3: University of Massachusetts Boston, Department of Physics, 100 Morrissey Boulevard, Boston, MA 02125, USA 4: Z-Tech Corporation, 3900 NCTR Road, Jefferson, AR 72079, USA 5: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 6: Biogen Idec Inc., 5200 Research Place, San Diego, CA 92122, USA 7: ViaLogy Inc., 2400 Lincoln Avenue, Altadena, CA 91001, USA 8: SAS Institute Inc., SAS Campus Drive, Cary, NC 27513, USA 9: Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA 10: Eppendorf Array Technologies, rue du Séminaire 20a, 5000 Namur, Belgium 11: Agilent Technologies Inc., 5301 Stevens Creek Boulevard, Santa Clara, CA 95051, USA 12: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310027, China; Source Info: 2008 Supplement 9, Vol. 9, Special section p1; Subject Term: GENES; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: STATISTICAL significance; Subject Term: T-test (Statistics); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 19p; Illustrations: 11 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-9-S9-S10
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701334&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taewon Lee
AU - Desai, Varsha G.
AU - Velasco, Cruz
AU - Reis, Robert J.
AU - Delongchamp, Robert R.
T1 - Testing for treatment effects on gene ontology.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2008/01/10/2008 Supplement 9
VL - 9
M3 - Article
SP - 1
EP - 9
PB - BioMed Central
SN - 14712105
AB - In studies that use DNA arrays to assess changes in gene expression, it is preferable to measure the significance of treatment effects on a group of genes from a pathway or functional category such as gene ontology terms (GO terms, http://www.geneontology.org) because this facilitates the interpretation of effects and may markedly increase significance. A modified meta-analysis method to combine p-values was developed to measure the significance of an overall treatment effect on such functionally-defined groups of genes, taking into account the correlation structure among genes. For hypothesis testing that allows gene expression to change in both directions, p-values are calculated under the null distribution generated by a Monte Carlo method. As a test of this procedure, we attempted to distinguish altered pathways in microarray studies performed with Mitochips, oligonucleotide microarrays specific to mitochondrial DNA-encoded transcripts. We found that our analytic method improves the specificity of selection for altered pathways, due to incorporation of the inter-gene correlation structure in each pathway. It is thus a practical method to measure treatment effects on GO groups. In many actual applications, microarray experiments measure treatment effects under complicated design structures and with small sample sizes. For such applications to real data of limited statistical power, and also in computer simulations, we demonstrate that our method gives reasonable test results. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - GENE expression
KW - META-analysis
KW - GENES
KW - MONTE Carlo method
KW - COMPUTER simulation
N1 - Accession Number: 35701345; Taewon Lee 1; Email Address: taewon70@korea.ac.kr Desai, Varsha G. 2; Email Address: varsha.desai@fda.hhs.gov Velasco, Cruz 3; Email Address: cvelas@lsuhsc.edu Reis, Robert J. 4; Email Address: rjsr@uams.edu Delongchamp, Robert R. 5; Email Address: RDelongchamp@uams.edu; Affiliation: 1: Department of Information and Mathematics, Korea University, Jochiwon, Chungnan 339-700, Korea 2: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Louisiana State University Health Sciences Center, New Orleans, LA 70112 4: Depts. of Geriatrics. Biochemistry & Molecular Biology, and Pharmacology/Toxicology, University of Arkansas for Medical Sciences, and VA Medical Center, Little Rock, AR 72205, USA 5: Department of Epidemiology, University of Arkansas for Medical Sciences, College of Public Health, 4301 W Markham St, #820, Little Rock, AR 72205, USA; Source Info: 2008 Supplement 9, Vol. 9, Special section p1; Subject Term: DNA microarrays; Subject Term: GENE expression; Subject Term: META-analysis; Subject Term: GENES; Subject Term: MONTE Carlo method; Subject Term: COMPUTER simulation; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-9-S9-S1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701345&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Wren, Jonathan D.
AU - Wilkins, Dawn
AU - Fuscoe, James C.
AU - Bridges, Susan
AU - Winters-Hilt, Stephen
AU - Gusev, Yuriy
T1 - Proceedings of the 2008 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2008/01/10/2008 Supplement 9
VL - 9
M3 - Proceeding
SP - 1
EP - 6
PB - BioMed Central
SN - 14712105
AB - The article discusses the highlights of the 2008 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference held in Oklahoma City, Oklahoma from February 23 to 24, 2008. Keynote speakers at the event were Doctors Bruce Roe and Edward Dougherty. Also mentioned are student posters award winners, including Vinay Ravindrakumar of University of Arkansas for Medical Sciences in Little Rock. One of the general themes of the papers accepted for inclusion in the official conference proceedings was systems biology.
KW - CONFERENCES & conventions
KW - BIOLOGY -- Societies, etc.
KW - COMPUTATIONAL biology
KW - BIOINFORMATICS
KW - OKLAHOMA City (Okla.)
KW - OKLAHOMA
KW - ROE, Bruce
N1 - Accession Number: 35701333; Wren, Jonathan D. 1; Email Address: Jonathan.Wren@OMRF.org Wilkins, Dawn 2; Email Address: dwilkins@cs.olemiss.edu Fuscoe, James C. 3; Email Address: james.fuscoe@fda.hhs.gov Bridges, Susan 4; Email Address: bridges@cse.msstate.edu Winters-Hilt, Stephen 5; Email Address: winters@cs.uno.edu Gusev, Yuriy 6; Email Address: Yuriy-Gusev@ouhsc.edu; Affiliation: 1: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation; 825 N.E. 13th Street, Oklahoma City, OK 73104-5005, USA 2: Computer & Information Science Department, The University of Mississippi, University, MS 38677, USA 3: Center for Functional Genomics, Division of Systems Toxicology; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 4: Department of Computer Science and Engineering, Mississippi State University, Box 9637, Mississippi State, MS 39762, USA 5: Department of Computer Science, University of New Orleans, and The Research Institute for Children, 200 Henry Clay Ave., New Orleans, LA 70118, USA 6: Department of Surgery, Health Sciences Center, The University of Oklahoma, Oklahoma City, OK 73104, USA; Source Info: 2008 Supplement 9, Vol. 9, Special section p1; Subject Term: CONFERENCES & conventions; Subject Term: BIOLOGY -- Societies, etc.; Subject Term: COMPUTATIONAL biology; Subject Term: BIOINFORMATICS; Subject Term: OKLAHOMA City (Okla.); Subject Term: OKLAHOMA; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; People: ROE, Bruce; Number of Pages: 6p; Document Type: Proceeding
L3 - 10.1186/1471-2105-9-S9-S1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701333&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhenqiang Su
AU - Huixiao Hong
AU - Hong Fang
AU - Leming Shi
AU - Perkins, Roger
AU - Tong, Weida
T1 - Very Important Pool (VIP) genes -- an application for microarray-based molecular signatures.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2008/01/10/2008 Supplement 9
VL - 9
M3 - Article
SP - 1
EP - 10
PB - BioMed Central
SN - 14712105
AB - Background: Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine. Derivation of biomarkers is a large step beyond hypothesis generation and imposes considerably more stringency for accuracy in identifying informative gene subsets to differentiate phenotypes. The inherent nature of microarray data, with fewer samples and replicates compared to the large number of genes, requires identifying informative genes prior to classifier construction. However, improving the ability to identify differentiating genes remains a challenge in bioinformatics. Results: A new hybrid gene selection approach was investigated and tested with nine publicly available microarray datasets. The new method identifies a Very Important Pool (VIP) of genes from the broad patterns of gene expression data. The method uses a bagging sampling principle, where the re-sampled arrays are used to identify the most informative genes. Frequency of selection is used in a repetitive process to identify the VIP genes. The putative informative genes are selected using two methods, t-statistic and discriminatory analysis. In the t-statistic, the informative genes are identified based on p-values. In the discriminatory analysis, disjoint Principal Component Analyses (PCAs) are conducted for each class of samples, and genes with high discrimination power (DP) are identified. The VIP gene selection approach was compared with the p-value ranking approach. The genes identified by the VIP method but not by the p-value ranking approach are also related to the disease investigated. More importantly, these genes are part of the pathways derived from the common genes shared by both the VIP and p-ranking methods. Moreover, the binary classifiers built from these genes are statistically equivalent to those built from the top 50 p-value ranked genes in distinguishing different types of samples. Conclusion: The VIP gene selection approach could identify additional subsets of informative genes that would not always be selected by the p-value ranking method. These genes are likely to be additional true positives since they are a part of pathways identified by the p-value ranking method and expected to be related to the relevant biology. Therefore, these additional genes derived from the VIP method potentially provide valuable biological insights. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - AUTOMATIC identification
KW - GENES
KW - GENE expression
KW - BIOCHEMICAL markers
KW - PRINCIPAL components analysis
N1 - Accession Number: 35701352; Zhenqiang Su 1; Email Address: zhenqiang.su@fda.hhs.gov Huixiao Hong 1; Email Address: huixiao.hong@fda.hhs.gov Hong Fang 2; Email Address: hong.fang@fda.hhs.gov Leming Shi 1; Email Address: leming.shi@fda.hhs.gov Perkins, Roger 2; Email Address: roger.perkins@fda.hhs.gov Tong, Weida 1; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA 2: Z-Tech, an ICF International Company at FDA's National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: 2008 Supplement 9, Vol. 9, Special section p1; Subject Term: DNA microarrays; Subject Term: AUTOMATIC identification; Subject Term: GENES; Subject Term: GENE expression; Subject Term: BIOCHEMICAL markers; Subject Term: PRINCIPAL components analysis; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 2 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1186/1471-2105-9-S9-S9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35701352&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sheehan, K. M.
AU - Gulmann, C.
AU - Eichler, G. S.
AU - Weinstein, J. N.
AU - Barrett, H. L.
AU - Kay, E. W.
AU - Conroy, R. M.
AU - Liotta, L. A.
AU - Petricoin III, E. F.
T1 - Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition.
JO - Oncogene
JF - Oncogene
Y1 - 2008/01/10/
VL - 27
IS - 3
M3 - Article
SP - 323
EP - 331
PB - Nature Publishing Group
SN - 09509232
AB - Molecular crosstalk, including reciprocal stimulation, is theorized to take place between epithelial cancer cells and surrounding non-neoplastic stromal cells. This is the rationale for stromal therapy, which could eliminate support of a cancer by its genetically stable stroma. Epithelial-stromal crosstalk is so far poorly documented in vivo, and cell cultures and animal experiments may not provide accurate models. The current study details stromal-epithelial signalling pathways in 35 human colon cancers, and compares them with matched normal tissues using quantitative proteomic microarrays. Lysates prepared from separately microdissected epithelium and stroma were analysed using antibodies against 61 cell signalling proteins, most of which recognize activated phospho-isoforms. Analyses using unsupervised and supervised statistical methods suggest that cell signalling pathway profiles in stroma and epithelium appear more similar to each other in tumours than in normal colon. This supports the concept that coordinated crosstalk occurs between epithelium and stroma in cancer and suggests epithelial-mesenchymal transition. Furthermore, the data herein suggest that it is driven by cell proliferation pathways and that, specifically, several key molecules within the mitogen-activated protein kinase pathway may play an important role. Given recent findings of epithelial-mesenchymal transition in therapy-resistant tumour epithelium, these findings could have therapeutic implications for colon cancer.Oncogene (2008) 27, 323–331; doi:10.1038/sj.onc.1210647; published online 9 July 2007 [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - PROTEIN microarrays
KW - COLON cancer
KW - MICRODISSECTION
KW - CANCER cells
KW - CELL culture
KW - colon cancer
KW - microdissection
KW - protein microarray
KW - proteomics
KW - stroma
N1 - Accession Number: 28331059; Sheehan, K. M. 1,2 Gulmann, C. 1,2; Email Address: christian_gulmann@hotmail.com Eichler, G. S. 3 Weinstein, J. N. 3 Barrett, H. L. 2 Kay, E. W. 2 Conroy, R. M. 4 Liotta, L. A. 1,5 Petricoin III, E. F. 5,6; Affiliation: 1: NCI-FDA Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Department of Pathology, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland 3: Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 4: Department of Epidemiology, Royal College of Surgeons in Ireland, Dublin, Ireland 5: Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA 6: NCI-FDA Clinical Proteomics Program, Food and Drug Administration, Bethesda, MD, USA; Source Info: 1/10/2008, Vol. 27 Issue 3, p323; Subject Term: PROTEOMICS; Subject Term: PROTEIN microarrays; Subject Term: COLON cancer; Subject Term: MICRODISSECTION; Subject Term: CANCER cells; Subject Term: CELL culture; Author-Supplied Keyword: colon cancer; Author-Supplied Keyword: microdissection; Author-Supplied Keyword: protein microarray; Author-Supplied Keyword: proteomics; Author-Supplied Keyword: stroma; Number of Pages: 9p; Illustrations: 2 Diagrams, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1038/sj.onc.1210647
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sam Haidar
AU - Barbara Davit
AU - Mei-Ling Chen
AU - Dale Conner
AU - LaiMing Lee
AU - Qian Li
AU - Robert Lionberger
AU - Fairouz Makhlouf
AU - Devvrat Patel
AU - Donald Schuirmann
AU - Lawrence Yu
T1 - Bioequivalence Approaches for Highly Variable Drugs and Drug Products.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2008/01/10/
VL - 25
IS - 1
M3 - Article
SP - 237
EP - 241
SN - 07248741
AB - Abstract  Over the past decade, concerns have been expressed increasingly regarding the difficulty for highly variable drugs and drug products (%CV greater than 30) to meet the standard bioequivalence (BE) criteria using a reasonable number of study subjects. The topic has been discussed on numerous occasions at national and international meetings. Despite the lack of a universally accepted solution for the issue, regulatory agencies generally agree that an adjustment of the traditional BE limits for these drugs or products may be warranted to alleviate the resource burden of studying relatively large numbers of subjects in bioequivalence trials. This report summarizes a careful examination of all the statistical methods available and extensive simulations for BE assessment of highly variable drugs/products. Herein, the authors present an approach of scaling an average BE criterion to the within-subject variability of the reference product in a crossover BE study, together with a point-estimate constraint imposed on the geometric mean ratio between the test and reference products. The use of a reference-scaling approach involves the determination of variability of the reference product, which requires replication of the reference treatment in each individual. A partial replicated-treatment design with this new data analysis methodology will thus provide a more efficient design for BE studies with highly variable drugs and drug products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Therapeutic equivalency
KW - BIOPHARMACEUTICS
KW - CLINICAL drug trials
KW - DRUG therapy
N1 - Accession Number: 28383685; Sam Haidar 1 Barbara Davit 1 Mei-Ling Chen 2 Dale Conner 1 LaiMing Lee 1 Qian Li 3 Robert Lionberger 1 Fairouz Makhlouf 3 Devvrat Patel 1 Donald Schuirmann 3 Lawrence Yu 1; Affiliation: 1: Food and Drug Administration Office of Generic Drugs 7500 Standish Place Rockville Maryland 20855 USA 2: Food and Drug Administration Office of Pharmaceutical Science 10903 New Hampshire Avenue Silver Spring Maryland 20993 USA 3: Food and Drug Administration Office of Biostatistics 10903 New Hampshire Avenue Silver Spring Maryland 20993 USA; Source Info: Jan2008, Vol. 25 Issue 1, p237; Subject Term: DRUGS -- Therapeutic equivalency; Subject Term: BIOPHARMACEUTICS; Subject Term: CLINICAL drug trials; Subject Term: DRUG therapy; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lorenz, Karl A.
AU - Lynn, Joanne
AU - Dy, Sydney M.
AU - Shugarman, Lisa R.
AU - Wilkinson, Anne
AU - Mularski, Richard A.
AU - Morton, Sally C.
AU - Hughes, Ronda G.
AU - Hilton, Lara K.
AU - Maglione, Margaret
AU - Rhodes, Shannon L.
AU - Rolon, Cony
AU - Sun, Virginia C.
AU - Shekelle, Paul G.
T1 - Evidence for Improving Palliative Care at the End of Life: A Systematic Review.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/01/15/
VL - 148
IS - 2
M3 - Article
SP - 147
EP - W28
SN - 00034819
AB - Background: Many persons and their families are burdened by serious chronic illness in late life. How to best support quality of life is an important consideration for care. Purpose: To assess evidence about interventions to improve palliative and end-of-life care. Data Sources: English-language citations (January 1990 to November 2005) from MEDLINE, the Database of Abstracts of Reviews of Effects, the National Consensus Project for Quality Palliative Care bibliography, and November 2005 to January 2007 updates from expert reviews and literature surveillance. Study Selection: Systematic reviews that addressed "end of life," including terminal illness (for example, advanced cancer) and chronic, eventually fatal illness with ambiguous prognosis (for example, advanced dementia), and intervention studies (randomized and nonrandomized designs) that addressed pain, dyspnea, depression, advance care planning, continuity, and caregiving. Data Extraction: Single reviewers screened 24 423 titles to find 6381 relevant abstracts and reviewed 1274 articles in detail to identify 33 high-quality systematic reviews and 89 relevant intervention studies. They synthesized the evidence by using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) classification. Data Synthesis: Strong evidence supports treating cancer pain with opioids, nonsteroidals, radionuclides, and radiotherapy; dyspnea from chronic lung disease with short-term opioids; and cancer-associated depression with psychotherapy, tricyclics, and selective serotonin reuptake inhibitors. Strong evidence supports multicomponent interventions to improve continuity in heart failure. Moderate evidence supports advance care planning led by skilled facilitators who engage key decision makers and interventions to alleviate caregiver burden. Weak evidence addresses cancer-related dyspnea management, and no evidence addresses noncancer pain, symptomatic dyspnea management in advanced heart failure, or short-acting antidepressants in terminal illness. No direct evidence addresses improving continuity for patients with dementia. Evidence was weak for improving caregiver burdens in cancer and was absent for heart failure. Limitations: Variable literature indexing for advanced chronic illness and end of life limited the comprehensiveness of searches, and heterogeneity was too great to do meta-analysis. Conclusion: Strong to moderate evidence supports interventions to improve important aspects of end-of-life care. Future research should quantify these effects and address the generalizability of insights across the conditions and settings of the last part of life. Many critical issues lack high-quality evidence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PALLIATIVE treatment
KW - CHRONIC diseases
KW - QUALITY of life
KW - CANCER
KW - MEDICARE
KW - DYSPNEA
KW - MENTAL depression
N1 - Accession Number: 28399257; Lorenz, Karl A. 1 Lynn, Joanne 2 Dy, Sydney M. 3 Shugarman, Lisa R. 4 Wilkinson, Anne 5 Mularski, Richard A. 6 Morton, Sally C. 7 Hughes, Ronda G. 8 Hilton, Lara K. 4 Maglione, Margaret 4 Rhodes, Shannon L. 4 Rolon, Cony 4 Sun, Virginia C. 4 Shekelle, Paul G. 1; Affiliation: 1: Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Code 111-G, Los Angeles, CA 90073 2: Center for Medicare & Medicaid Services, Office of Standards and Quality, 7500 Security Boulevard, Mail Stop S3-02-01, Baltimore, MD 21244-1850 3: Johns Hopkins Bloomberg School of Public Health, Room 609, 624 North Broadway, Baltimore, MD 21205 4: RAND Corporation, 1776 Main Street, Santa Monica, CA 90401-3208 5: Western Australia Center for Cancer and Palliative Care, Edith Cowan University, Building 19, Churchlands Campus, Pearson Street, Churchlands, WA 6018, Australia 6: Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate, WIN 1060, Portland, OR 97227 7: Research Triangle Institute, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709-2194 8: Agency for Healthcare Research and Quality, John M. Eisenberg Building, 540 Gaither Road, Rockville, MD 20850; Source Info: 1/15/2008, Vol. 148 Issue 2, p147; Subject Term: PALLIATIVE treatment; Subject Term: CHRONIC diseases; Subject Term: QUALITY of life; Subject Term: CANCER; Subject Term: MEDICARE; Subject Term: DYSPNEA; Subject Term: MENTAL depression; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 15p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siegel, Jeffrey
T1 - Comparative Effectiveness of Treatments for Rheumatoid Arthritis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/01/15/
VL - 148
IS - 2
M3 - Article
SP - 162
EP - 163
SN - 00034819
AB - The article discusses various reports published within the issue, including one by Donahue and colleagues on a systematic review of the literature comparing the benefits and harms associated with different disease-modifying antirheumatic drugs (DMARDs), used alone or in combination and another on the American College of Rheumatology's guidelines for managing rheumatoid arthritis.
KW - DRUGS
KW - RHEUMATOID arthritis
N1 - Accession Number: 28399259; Siegel, Jeffrey 1; Affiliation: 1: U.S. Food and Drug Administration, Silver Spring, MD 20910; Source Info: 1/15/2008, Vol. 148 Issue 2, p162; Subject Term: DRUGS; Subject Term: RHEUMATOID arthritis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yauk, Carole
AU - Polyzos, Aris
AU - Rowan-Carroll, Andrea
AU - Somers, Christopher M.
AU - Godschalk, Roger W.
AU - Van Schooten, Frederik J.
AU - Berndt, M. Lynn
AU - Pogribny, Igor P.
AU - Koturbash, Igor
AU - Williams, Andrew
AU - Douglas, George R.
AU - Kovalchuk, Olga
T1 - Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2008/01/15/
VL - 105
IS - 2
M3 - Article
SP - 605
EP - 610
SN - 00278424
AB - Particulate air pollution is widespread, yet we have little understanding of the long-term health implications associated with exposure. We investigated DNA damage, mutation, and methylation in gametes of male mice exposed to particulate air pollution in an industrial/ urban environment. C57BL/CBA mice were exposed in situ to ambient air near two integrated steel mills and a major highway, alongside control mice breathing high-efficiency air particulate (HEPA) filtered ambient air. PCR analysis of an expanded simple tandem repeat (ESTR) locus revealed a 1.6-fold increase in sperm mutation frequency in mice exposed to ambient air for 10 wks. followed by a 6-wk break, compared with HEPA-filtered air, indicating that mutations were induced in spermatogonial stem cells. DNA collected after 3 or 10 wks of exposure did not exhibit increased mutation frequency. Bulky DNA adducts were below the detection threshold in testes samples, suggesting that DNA reactive chemicals do not reach the germ line and cause ESTR mutation. In contrast. DNA strand breaks were elevated at 3 and 10 wks, possibly resulting from oxidative stress arising from exposure to particles and associated airborne pollutants. Sperm DNA was hypermethylated in mice breathing ambient relative to HEPA-filtered air and this change persisted following removal from the environmental exposure. Increased germ-line DNA mutation frequencies may cause population-level changes in genetic composition and disease. Changes in methylation can have widespread repercussions for chromatin structure, gene expression and genome stability. Potential health effects warrant extensive further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AIR pollution
KW - DNA damage
KW - MUTATION (Biology)
KW - METHYLATION
KW - ANIMAL mutation
KW - MUTAGENESIS
KW - DNA adducts
KW - DNA strand breaks
KW - tandem repeat mutation
N1 - Accession Number: 28781303; Yauk, Carole 1,2; Email Address: carole_yauk@hc-sc.gc.ca Polyzos, Aris 1 Rowan-Carroll, Andrea 1 Somers, Christopher M. 2 Godschalk, Roger W. 3 Van Schooten, Frederik J. 3 Berndt, M. Lynn 1 Pogribny, Igor P. 4 Koturbash, Igor 5 Williams, Andrew 6 Douglas, George R. 1 Kovalchuk, Olga 6; Affiliation: 1: Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9 2: Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 3: Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Department of Health Risk Analysis and Toxicology, Maastricht University, 6200 MD, P0 Box 616, Maastricht, The Netherlands 4: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079 5: Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alta., Canada T1K 3M4 6: Biostatistics and Epidemiology Division, Healthy Environments and Consumer Safety Branch, Ottawa, ON, Canada K1A 0K9; Source Info: 1/15/2008, Vol. 105 Issue 2, p605; Subject Term: AIR pollution; Subject Term: DNA damage; Subject Term: MUTATION (Biology); Subject Term: METHYLATION; Subject Term: ANIMAL mutation; Subject Term: MUTAGENESIS; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: DNA strand breaks; Author-Supplied Keyword: tandem repeat mutation; Number of Pages: 6p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1073/pnas.0705896105
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Divi, Rao L.
AU - Doerge, Daniel R.
AU - Twaddle, Nathan C.
AU - Shockley, Marie E.
AU - St. Claire, Marisa C.
AU - Harbaugh, Jeffrey W.
AU - Harbaugh, Steven W.
AU - Poirier, Miriam C.
T1 - Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/01/15/
VL - 226
IS - 2
M3 - Article
SP - 206
EP - 211
SN - 0041008X
AB - Abstract: Because of their similarity to humans, non-human primates constitute useful preclinical models in which to examine potential human drug toxicities. Antiretroviral nucleoside reverse transcriptase inhibitor (NRTI) toxicity is currently under investigation in Erythrocebus patas monkeys, and whereas NRTI pharmacokinetics have been studied in other monkey species, pharmacokinetics for Zidovudine plus Lamivudine (AZT/3TC) dosing have not been reported in the patas. Here we present 24 h serum pharmacokinetic parameters after a single oral exposure to the combination of AZT (40 mg) and 3TC (24 mg), doses equivalent to a human daily dose of Combivir®. The patas (n =3) AZT/3TC pharmacokinetic profiles were similar to those seen in other primate species. Average maximum serum concentrations (C max) for AZT and 3TC were 2.35 and 2.65 μg/ml, respectively, and were observed at 0.83 h (T max). C max was 13.34 μg/ml for the AZT-glucuronide (AZT-G) and was 0.023 μg/ml for the potentially toxic minor metabolite 3′-amino-3′-deoxythymidine (AMT), both occurring at about 1 h after dosing. Similar elimination half-times, 0.70 and 0.68 h−1, were found for AZT and AZT-G, respectively, while 3TC was eliminated about half as fast (0.33 h−1) resulting in AUC(0–∞) values of 6.97 μg/ml h for 3TC, 2.99 μg/ml h for AZT, 20.5 μg/ml h for AZT-G and 0.002 for AMT 6.97 μg/ml h. This study shows similar metabolism and pharmacokinetics for oral administration of AZT/3TC in the adult patas monkey, other primate species and humans. The data validate the use of the patas monkey for studies of NRTI toxicity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - PHARMACOKINETICS
KW - AZT (Drug)
KW - LIQUID chromatography
KW - 3′-amino-3′-deoxythymidine ( AMT )
KW - 3′-dideoxy-3′-thiacytidine ( 3TC )
KW - 3TC
KW - AMT
KW - area under the concentration×time curve for the parent drug and metabolites ( AUC(0–∞) )
KW - AZT
KW - AZT-5′-glucuronide ( AZT-G )
KW - AZT-glucuronide
KW - Combivir
KW - elimination constant ( k-elim )
KW - human immunodeficiency virus-1 ( HIV-1 )
KW - Lamivudine or (−)2′
KW - Lamivudine or (−)2′,3′-dideoxy-3′-thiacytidine ( 3TC )
KW - liquid chromatography ( LC )
KW - mass spectrometry ( MS )
KW - maximum concentration of drug ( C max )
KW - nucleoside reverse transcriptase inhibitor ( NRTI )
KW - Serum
KW - solid phase extraction ( SPE )
KW - Tandem mass spectrometry
KW - time at which drug concentration is highest ( T max )
KW - time in which serum drug concentration is decreased by half ( t 1/2 )
KW - Zidovudine or 3′-azido-3′-deoxythymidine ( AZT )
N1 - Accession Number: 28009939; Divi, Rao L. 1 Doerge, Daniel R. 2 Twaddle, Nathan C. 2 Shockley, Marie E. 1 St. Claire, Marisa C. 3 Harbaugh, Jeffrey W. 3 Harbaugh, Steven W. 3 Poirier, Miriam C. 1; Email Address: poirierm@exchange.nih.gov; Affiliation: 1: Carcinogen–DNA Interactions Section, LCBG, CCR, National Cancer Institute, Bldg. 37. Rm. 4032 NIH, 37 Convent Drive, Bethesda, MD 20892-4255, USA 2: Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, HFT 110, 3900 NCTR Road, Jefferson, AR 72079, USA 3: BioQual Inc., 2501 Research Blvd., Rockville, MD 20850, USA; Source Info: Jan2008, Vol. 226 Issue 2, p206; Subject Term: METABOLISM; Subject Term: PHARMACOKINETICS; Subject Term: AZT (Drug); Subject Term: LIQUID chromatography; Author-Supplied Keyword: 3′-amino-3′-deoxythymidine ( AMT ); Author-Supplied Keyword: 3′-dideoxy-3′-thiacytidine ( 3TC ); Author-Supplied Keyword: 3TC; Author-Supplied Keyword: AMT; Author-Supplied Keyword: area under the concentration×time curve for the parent drug and metabolites ( AUC(0–∞) ); Author-Supplied Keyword: AZT; Author-Supplied Keyword: AZT-5′-glucuronide ( AZT-G ); Author-Supplied Keyword: AZT-glucuronide; Author-Supplied Keyword: Combivir; Author-Supplied Keyword: elimination constant ( k-elim ); Author-Supplied Keyword: human immunodeficiency virus-1 ( HIV-1 ); Author-Supplied Keyword: Lamivudine or (−)2′; Author-Supplied Keyword: Lamivudine or (−)2′,3′-dideoxy-3′-thiacytidine ( 3TC ); Author-Supplied Keyword: liquid chromatography ( LC ); Author-Supplied Keyword: mass spectrometry ( MS ); Author-Supplied Keyword: maximum concentration of drug ( C max ); Author-Supplied Keyword: nucleoside reverse transcriptase inhibitor ( NRTI ); Author-Supplied Keyword: Serum; Author-Supplied Keyword: solid phase extraction ( SPE ); Author-Supplied Keyword: Tandem mass spectrometry; Author-Supplied Keyword: time at which drug concentration is highest ( T max ); Author-Supplied Keyword: time in which serum drug concentration is decreased by half ( t 1/2 ); Author-Supplied Keyword: Zidovudine or 3′-azido-3′-deoxythymidine ( AZT ); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.taap.2007.09.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McMahon, A.W.
AU - Iskander, J.K.
AU - Haber, P.
AU - Braun, M.M.
AU - Ball, R.
T1 - Inactivated influenza vaccine (IIV) in children <2 years of age: Examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2008/01/17/
VL - 26
IS - 3
M3 - Article
SP - 427
EP - 429
SN - 0264410X
AB - Summary: Thimerosal as a preservative (in all but trace amounts) was removed from vaccines used in infants starting in the late 1990s, though the preservative-including inactivated influenza vaccine is still available for use in individuals ≥6 months of age. We compared the proportion of injection site reactions, rash, and infections reported to the Vaccine Adverse Event Reporting System (VAERS) after preservative-free (PFV), preservative-including (PIV), and preservative unknown (PUV) vaccines in reports from 7/1/2004 to 1/4/2006. There were 145, 175, and 216 reports after vaccination with PFV, PIV, and PUV, respectively. The most frequently reported coding terms (fever, rash, and urticaria) were seen in similar proportions in the PFV, PIV, and PUV groups. No difference was detected in the proportion of injection site reactions (ISR), rash, or infections in the PIV, PFV, and PUV reports. Keeping in mind the inherent limitations of VAERS, including underreporting and potential reporting biases, we conclude that there were no substantial differences in the proportion of rash, ISR, and infection reports in the PIV, PFV and PUV reports in infants. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Influenza
KW - Immunization of children
KW - Preventive medicine
KW - Adverse event
KW - Infant
KW - Influenza vaccine
KW - Thimerosal
N1 - Accession Number: 28149691; McMahon, A.W. 1; Email Address: ann.mcmahon@fda.hhs.gov; Iskander, J.K. 2; Haber, P. 2; Braun, M.M. 1; Ball, R. 1; Affiliations: 1: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, USA; 2: Immunization Safety Office, Centers for Disease Control and Prevention, USA; Issue Info: Jan2008, Vol. 26 Issue 3, p427; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Subject Term: Influenza; Subject Term: Immunization of children; Subject Term: Preventive medicine; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Infant; Author-Supplied Keyword: Influenza vaccine; Author-Supplied Keyword: Thimerosal; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.vaccine.2007.10.071
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ying-Xin Fan
AU - Wong, Lily
AU - Jinhui Ding
AU - Spiridonov, Nikolay A.
AU - Johnson, Richard C.
AU - Johnson, Gibbes R.
T1 - Mutational Activation of ErbB2 Reveals a New Protein Kinase Autoinhibition Mechanism.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008/01/18/
VL - 283
IS - 3
M3 - Article
SP - 1588
EP - 1596
SN - 00219258
AB - Autoinhibition plays a key role in the control of protein kinase activity. ErbB2 is a unique receptor-tyrosine kinase that does not bind ligand but possesses an extracellular domain poised to engage other ErbBs. Little is known about the molecular mechanism for ErbB2 catalytic regulation. Here we show that ErbB2 kinase is strongly autoinhibited, and a loop connecting the αC helix and β4 sheet within the kinase domain plays a major role in the control of kinase activity. Mutations of two Gly residues at positions 776 and 778 in this loop dramatically increase ErbB2 catalytic activity. Kinetic analysis demonstrates that mutational activation is due to ∼10- and ∼7-fold increases in ATP binding affinity and turnover number, respectively. Expression of the activated ErbB2 mutants in cells resulted in elevated ligand-independent ErbB2 autophosphorylation, ErbB3 phosphorylation, and stimulation of mitogen-activated protein kinase. Molecular modeling suggests that the ErbB2 kinase domain is stabilized in an inactive state via a hydrophobic interaction between the αC-β4 and activation loops. Importantly, many ErbB2 human cancer mutations have been identified in the αC-β4 loop, including the activating G776S mutation studied here. Our findings reveal a new kinase regulatory mechanism in which the αC-β4 loop functions as an intramolecular switch that controls ErbB2 activity and suggests that loss of αC-β4 loop-mediated autoinhibition is involved in oncogenic activation of ErbB2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUTATION (Biology)
KW - GENETICS
KW - PROTEIN kinases
KW - CYCLIN-dependent kinases
KW - PHOSPHOTRANSFERASES
KW - GLYCOGEN synthase kinase-3
N1 - Accession Number: 29343464; Ying-Xin Fan 1; Email Address: ying-xin.fan@fda.hhs.gov Wong, Lily 1 Jinhui Ding 2 Spiridonov, Nikolay A. 1 Johnson, Richard C. 3 Johnson, Gibbes R. 1; Email Address: gibbes.johnson@fda.hhs.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration 2: Bioinformatics Section, Laboratory of Neuro genetics, NIA, National Institutes of Health, Bethesda Maryland 20892 3: Department of Neuroscience, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205; Source Info: 1/18/2008, Vol. 283 Issue 3, p1588; Subject Term: MUTATION (Biology); Subject Term: GENETICS; Subject Term: PROTEIN kinases; Subject Term: CYCLIN-dependent kinases; Subject Term: PHOSPHOTRANSFERASES; Subject Term: GLYCOGEN synthase kinase-3; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M708116200
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wysowski, Diane K.
T1 - In reply.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2008/01/28/
VL - 168
IS - 2
M3 - Letter
SP - 237
EP - 237
SN - 00039926
AB - A response by Diane K. Wysowski to a letter to the editor about the risk of a drug safety hazard in the previous issue is presented.
KW - LETTERS to the editor
KW - DRUGS -- Safety measures
N1 - Accession Number: 28790487; Wysowski, Diane K. 1; Email Address: diane.wysowski@fda.hhs.gov; Affiliation: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD 20993; Source Info: 1/28/2008, Vol. 168 Issue 2, p237; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Safety measures; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bush, Donna M.
T1 - The U.S. Mandatory Guidelines for Federal Workplace Drug Testing Programs: Current status and future considerations
JO - Forensic Science International
JF - Forensic Science International
Y1 - 2008/01/30/
VL - 174
IS - 2/3
M3 - Article
SP - 111
EP - 119
SN - 03790738
AB - Abstract: The U.S. Department of Health and Human Services (HHS) drug testing standards were published in 1988 and revised in 1994, 1998, and 2004. In 2004, significant revisions defining, standardizing, and requiring specimen validity testing on Federal employee donor urine specimens were included. In a separate notice, HHS proposed to establish scientific and technical guidelines for the Federal Workplace Drug Testing Program to: (1) permit laboratory testing of hair, oral fluid, and sweat patch specimens in addition to urine specimens for marijuana, cocaine, phencyclidine, opiates (with focus on heroin), and amphetamines [including methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDEA), methylenedioxyamphetamine (MDA)]; (2) permit use of on-site point of collection test (POCT) devices to test urine and oral fluid at collection sites; (3) permit use of instrumented initial test (screening only) facilities [IITF] to quickly identify negative specimens; and (4) add training requirement for collectors, on-site testers, and MROs. This proposal was published in the Federal Register on 13 April 2004, with a 90-day public comment period. The Substance Abuse and Mental Health Services Administration, HHS, reviewed those comments and is preparing the Final Notice that will define the requirements for such testing, including: specimen collection procedures, custody and control procedures that ensure donor specimen identity and integrity, testing facility, initial and confirmatory test cutoff concentrations, analytical testing methods, result review and reporting, evaluation of alternative medical explanations for presence of drug or metabolite in the donor''s specimen, and laboratory certification issues. Voluntary pilot performance testing (PT) programs for each specimen type are on-going since April 2000 to determine how to prepare PT materials for specimens other than urine to evaluate laboratories’ ability to routinely achieve accuracy and precision required. Certification programs will be developed using the current urine drug testing National Laboratory Certification Program model. The addition of accurate and reliable workplace drug testing using hair, oral fluid, and sweat patch specimens will complement urine drug testing, and aid in combating industries devoted to suborning drug testing through adulteration, substitution, and dilution. For example, hair testing may detect chronic drug use for up to 90 days and be useful in pre-employment situations; oral fluid testing may detect drug use in past hours and be useful in post-accident situations; sweat patch testing may be useful in follow-up drug testing and treatment programs; POCTs and IITFs may be most useful for quickly identifying specimens that are negative for drugs and indicate that the specimen is valid. [Copyright &y& Elsevier]
AB - Copyright of Forensic Science International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG use testing
KW - MEDICAL screening
KW - WORK environment
KW - HALLUCINOGENIC drugs
KW - Performance testing
KW - Regulatory requirements
KW - Specimen validity testing
KW - Workplace drug testing
N1 - Accession Number: 28151526; Bush, Donna M. 1; Email Address: Donna.Bush@samhsa.hhs.gov; Affiliation: 1: Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, One Choke Cherry Road, Room 2-1033, Rockville, MD 20857, USA; Source Info: Jan2008, Vol. 174 Issue 2/3, p111; Subject Term: DRUG use testing; Subject Term: MEDICAL screening; Subject Term: WORK environment; Subject Term: HALLUCINOGENIC drugs; Author-Supplied Keyword: Performance testing; Author-Supplied Keyword: Regulatory requirements; Author-Supplied Keyword: Specimen validity testing; Author-Supplied Keyword: Workplace drug testing; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.forsciint.2007.03.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28151526&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Cummings, Kristin J.
AU - Kreiss, Kathleen
T1 - Contingent Workers and Contingent Health.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/01/30/
VL - 299
IS - 4
M3 - Editorial
SP - 448
EP - 450
SN - 00987484
AB - The authors discuss the higher risk of work-related injuries and illness among contingent workers. The incidence of nontraditional work relationships in the U.S. and in Europe are mentioned. Hypotheses advanced to explain the difference in health risks between contingent and traditional workers are explored.
KW - CONTINGENT employment
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL diseases -- Risk factors
KW - ALTERNATIVE work arrangements
N1 - Accession Number: 28740146; Cummings, Kristin J. 1; Email Address: cvx5@cdc.gov Kreiss, Kathleen 1; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.; Source Info: 1/30/2008, Vol. 299 Issue 4, p448; Subject Term: CONTINGENT employment; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL diseases -- Risk factors; Subject Term: ALTERNATIVE work arrangements; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joffe, Hylton V.
T1 - COMPLEMENTARY THERAPIES AND THE MANAGEMENT OF DIABETES AND VASCULAR DISEASE: A MATTER OF BALANCE.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/01/30/
VL - 299
IS - 4
M3 - Book Review
SP - 458
EP - 459
SN - 00987484
AB - This article reviews the book "Complementary Therapies and the Management of Diabetes and Vascular Disease: A Matter of Balance," edited by T. Dunning.
KW - ALTERNATIVE medicine
KW - NONFICTION
KW - DUNNING, T.
KW - COMPLEMENTARY Therapies & the Management of Diabetes & Vascular Disease: A Matter of Balance (Book)
N1 - Accession Number: 28740152; Joffe, Hylton V. 1; Email Address: hjoffel@hotmail.com; Affiliation: 1: US Food and Drug Administration Rockville, Maryland; Source Info: 1/30/2008, Vol. 299 Issue 4, p458; Subject Term: ALTERNATIVE medicine; Subject Term: NONFICTION; Reviews & Products: COMPLEMENTARY Therapies & the Management of Diabetes & Vascular Disease: A Matter of Balance (Book); People: DUNNING, T.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105862754
T1 - Contingent workers and contingent health: risks of a modern economy.
AU - Cummings KJ
AU - Kreiss K
AU - Cummings, Kristin J
AU - Kreiss, Kathleen
Y1 - 2008/01/30/
N1 - Accession Number: 105862754. Language: English. Entry Date: 20080314. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Employment -- Ethical Issues
KW - Employment -- Legislation and Jurisprudence
KW - Employment -- Trends
KW - Employment
KW - Occupational Health
KW - Public Health
KW - Government
KW - Human Rights
KW - Private Sector
KW - United States
SP - 448
EP - 450
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 299
IS - 4
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov
U2 - PMID: 18230783.
DO - 10.1001/jama.299.4.448
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bhattacharjee, Ashish
AU - Mishra, Ravi S.
AU - Feldman, Gerald M.
AU - Cathcart, Martha K.
T1 - In vivo validation of signaling pathways regulating human monocyte chemotaxis
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2008/01/31/
VL - 330
IS - 1/2
M3 - Article
SP - 86
EP - 95
SN - 00221759
AB - Abstract: Identification of novel signal transduction pathways regulating monocyte chemotaxis can indicate unique targets for preventive therapies for treatment of chronic inflammatory diseases. To aid in this endeavor we report conditions for optimal transfection of primary human monocytes coupled with a new model system for assessing their chemotactic activity in vivo. This method can be used as a tool to identify the relevant signal transduction pathways regulating human monocyte chemotaxis to MCP-1 in the complex in vivo environment that were previously identified to regulate chemotaxis in vitro. MCP-1-dependent chemotaxis of monocytes is studied in an adoptive transfer model where human monocytes transfected with mutant cDNAs are transferred to mice followed by initiation of peritonitis. Harvesting peritoneal cells at 24 h diminishes the contribution of immunologic responses to the cross-species transfer. Validation of relevant regulatory molecules in vivo is critical for understanding the most relevant therapeutic targets for drug development. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCYTES
KW - CHEMOTAXIS
KW - IMMUNOLOGY
KW - DISEASES
KW - Adoptive transfer
KW - Bovine calf serum. ( BCS )
KW - Chemotaxis
KW - Human monocyte nucleofector medium ( MNM )
KW - Monocyte chemoattractant protein 1 ( MCP-1 )
KW - Monocytes
KW - Opti-MEM I medium ( OPT )
KW - PKCβ
KW - Transfection
N1 - Accession Number: 28754044; Bhattacharjee, Ashish 1 Mishra, Ravi S. 1 Feldman, Gerald M. 2 Cathcart, Martha K. 1,3; Email Address: cathcam@ccf.org; Affiliation: 1: Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA 2: Division of Monoclonal Antibodies, Office of Therapeutics, Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Source Info: Jan2008, Vol. 330 Issue 1/2, p86; Subject Term: MONOCYTES; Subject Term: CHEMOTAXIS; Subject Term: IMMUNOLOGY; Subject Term: DISEASES; Author-Supplied Keyword: Adoptive transfer; Author-Supplied Keyword: Bovine calf serum. ( BCS ); Author-Supplied Keyword: Chemotaxis; Author-Supplied Keyword: Human monocyte nucleofector medium ( MNM ); Author-Supplied Keyword: Monocyte chemoattractant protein 1 ( MCP-1 ); Author-Supplied Keyword: Monocytes; Author-Supplied Keyword: Opti-MEM I medium ( OPT ); Author-Supplied Keyword: PKCβ; Author-Supplied Keyword: Transfection; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jim.2007.11.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105876204
T1 - Epidural conduction device fractures and complications of retained fragments.
AU - Fischer R
Y1 - 2008/02//
N1 - Accession Number: 105876204. Language: English. Entry Date: 20080404. Revision Date: 20150820. Publication Type: Journal Article; case study; pictorial; website. Journal Subset: Blind Peer Reviewed; Core Nursing; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Advanced Nursing Practice; Patient Safety; Perioperative Care. NLM UID: 0431420.
KW - Adverse Health Care Event
KW - Catheter-Related Complications
KW - Epidural Catheters -- Adverse Effects
KW - Foreign Bodies
KW - Voluntary Reporting
SP - 37
EP - 40
JO - AANA Journal
JF - AANA Journal
JA - AANA J
VL - 76
IS - 1
CY - Park Ridge, Illinois
PB - American Association of Nurse Anesthetists
AB - During the past 3 years, the US Food and Drug Administration (FDA) has received a growing number of adverse event reports on the breakage or fracturing and retention of anesthetic conduction device tips with associated complications. Serious injuries and other problems such as spinal stenosis, nerve root compression, and subcutaneous effusion can result. Several case reports demonstrate how the problems occur; some illustrate the severity of the problem. All cases are from adverse event reports in the FDA Center for Devices and Radiological Health (CDRH) Manufacturer and User Facility Device Experience database. Frequently, in the interest of not causing patient harm, a device fragment might not be removed as long as the patient is not neurologically compromised or at risk for infection or there is little potential for migration of the fragmented piece. On many occasions, the fragments remain in patients without their knowledge. The FDA wants to raise awareness of the problem and its potential impact in creating complications, encourage the practice of in forming patients of the fragmented device, and promote reporting of such incidents to CDRH via the Med Watch reporting system. Based on a search of the current literature, recommendations for prevention are suggested.
SN - 0094-6354
AD - Food and Drug Administration, Center for Devices and Radiological Health, Office of Surveillance and Biometrics, Division of Postmarket Surveillance, Rockville, MD
U2 - PMID: 18323318.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105901631
T1 - Toward consistent use of reporting scales in imaging studies.
AU - Wagner RF
Y1 - 2008/02//
N1 - Accession Number: 105901631. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 9440159.
KW - Diagnosis, Computer Assisted -- Statistics and Numerical Data
KW - Diagnostic Imaging -- Statistics and Numerical Data
KW - Documentation -- Statistics and Numerical Data
KW - Observer Bias
KW - Data Analysis, Statistical
KW - Nomenclature
KW - Patient Record Systems
KW - Practice Patterns
KW - ROC Curve
SP - 137
EP - 138
JO - Academic Radiology
JF - Academic Radiology
JA - ACAD RADIOL
VL - 15
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1076-6332
AD - Office and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3126, Silver Spring MD 20993.
U2 - PMID: 18206612.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Andrade, Susan E.
AU - Raebel, Marsha A.
AU - Brown, Jeffrey
AU - Lane, Kimberly
AU - Livingston, James
AU - Boudreau, Denise
AU - Rolnick, Sharon J.
AU - Roblin, Douglas
AU - Smith, David H.
AU - Willy, Mary E.
AU - Staffa, Judy A.
AU - Platt, Richard
T1 - Use of antidepressant medications during pregnancy: a multisite study
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2008/02//
VL - 198
IS - 2
M3 - Article
SP - 194
EP - 194
SN - 00029378
AB - Objective: This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States. Study Design: A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days. Results: Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005. Conclusion: Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIDEPRESSANTS
KW - PREGNANT women -- Medical care
KW - PSYCHIATRIC drugs
KW - DRUGS -- Side effects
KW - DRUGS -- Physiological effect
KW - UNITED States
KW - antidepressant drugs
KW - pregnancy
N1 - Accession Number: 28690207; Andrade, Susan E. 1,2; Email Address: sandrade@meyersprimary.org; Raebel, Marsha A. 2,3; Brown, Jeffrey 2,4; Lane, Kimberly 2,4; Livingston, James 2,4; Boudreau, Denise 2,5; Rolnick, Sharon J. 2,6; Roblin, Douglas 2,7; Smith, David H. 2,8; Willy, Mary E. 9; Staffa, Judy A. 9; Platt, Richard 2,4; Source Information: Feb2008, Vol. 198 Issue 2, p194; Subject: ANTIDEPRESSANTS; Subject: PREGNANT women -- Medical care; Subject: PSYCHIATRIC drugs; Subject: DRUGS -- Side effects; Subject: DRUGS -- Physiological effect; Geographic Terms: UNITED States; Author-Supplied Keyword: antidepressant drugs; Author-Supplied Keyword: pregnancy; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2007.07.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=28690207&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Sihoon Lee
AU - Muniyappa, Ranganath
AU - Xu Yan
AU - Hui Chen
AU - Yue, Lilly Q.
AU - Eun-Gyoung Hong
AU - Kim, Jason K.
AU - Quon, Michael J.
T1 - Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice.
JO - American Journal of Physiology: Endocrinology & Metabolism
JF - American Journal of Physiology: Endocrinology & Metabolism
Y1 - 2008/02//
VL - 57
IS - 2
M3 - Article
SP - E261
EP - E270
SN - 01931849
AB - Insulin resistance contributes to the pathophysiology of diabetes, obesity, and their cardiovascular complications. Mouse models of these human diseases are useful for gaining insight into pathophysiological mechanisms. The reference standard for measuring insulin sensitivity in both humans and animals is the euglycemic glucose clamp. Many studies have compared surrogate indexes of insulin sensitivity and resistance with glucose clamp estimates in humans. However, regulation of metabolic physiology in humans and rodents differs and comparisons between surrogate indexes and the glucose clamp have not been directly evaluated in rodents previously. Therefore, in the present study, we compared glucose clamp-derived measures of insulin sensitivity (GIR and SIclamp) with surrogate indexes, including quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment (HOMA), 1/HOMA, log(HOMA), and 1/fasting insulin, using data from 87 mice with a wide range of insulin sensitivities. We evaluated simple linear correlations and performed calibration model analyses to evaluate the predictive accuracy of each surrogate. All surrogate indexes tested were modestly correlated with both GIR and SIClamp. However, a stronger correlation between body weight per se and both GIR and SIClamp was noted. Calibration analyses of surrogate indexes adjusted for body weight demonstrated improved predictive accuracy for GIR [e.g., R = 0.68, for QUICKI and log(HOMA)]. We conclude that linear correlations of surrogate indexes with clamp data and predictive accuracy of surrogate indexes in mice are not as substantial as in humans. This may reflect intrinsic differences between human and rodent physiology as well as increased technical difficulties in performing glucose clamps in mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Endocrinology & Metabolism is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN
KW - PATHOLOGICAL physiology
KW - DIABETES
KW - GLUCOSE
KW - BODY weight
KW - MICE as laboratory animals
KW - calibration model
KW - quantitative insulin-sensitivity check index
N1 - Accession Number: 29990028; Sihoon Lee 1; Email Address: quonm@nih.gov Muniyappa, Ranganath 1 Xu Yan 2 Hui Chen 1 Yue, Lilly Q. 2 Eun-Gyoung Hong 3 Kim, Jason K. 3 Quon, Michael J. 1; Email Address: quonm@nih.gov; Affiliation: 1: Diabetes Unit, National Center for Complementary and Alternative Medicine, National institutes of Health, Bethesda, Maryland 2: Division of Biostatistics, Center for Devices and Radiological Health, United States Food and Drug Administration, Rockville, Maryland 3: Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Source Info: Feb2008, Vol. 57 Issue 2, pE261; Subject Term: INSULIN; Subject Term: PATHOLOGICAL physiology; Subject Term: DIABETES; Subject Term: GLUCOSE; Subject Term: BODY weight; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: calibration model; Author-Supplied Keyword: quantitative insulin-sensitivity check index; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1152/ajpendo.00676.2007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Burckart, Gilbert J.
AU - Amur, Shashi
AU - Goodsaid, Federico M.
AU - Lesko, Lawrence J.
AU - Frueh, Felix W.
AU - Huang, Shiew-Mei
AU - Cavaille-Coll, Marc W.
T1 - Qualification of Biomarkers for Drug Development in Organ Transplantation.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2008/02//
VL - 8
IS - 2
M3 - Article
SP - 267
EP - 270
PB - Wiley-Blackwell
SN - 16006135
AB - The drug development process is dependent upon having established end points for measuring drug efficacy and adverse effects. New drug development in organ transplantation suffers from having end points which are either outdated or which do not serve the purpose of addressing the current critical drug therapy problems. Numerous biomarkers have been examined in organ transplantation, but almost all would be classified as exploratory for drug development purposes. Some of the possible pathways out of this dilemma include investigator- or consortium-initiated research that would qualify the biomarkers as either probable or known valid biomarkers, help in identification of new end points in transplantation and their associated biomarkers, co-development of a new biomarker and drug for transplantation and the use of new clinical trial design methods which facilitate enriched or stratified transplant patient populations. With new biomarkers and new study design methodologies for drug development, improvement in the drug development process for transplantation is a real possibility that the transplant clinical and research community can help to bring about. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - DRUG development
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DRUG therapy
KW - CLINICAL trials
KW - Biomarker
KW - drug development
KW - drugs
KW - end points
KW - surrogate end points
N1 - Accession Number: 28397199; Burckart, Gilbert J. 1; Email Address: burckart@usc.edu Amur, Shashi 1 Goodsaid, Federico M. 1 Lesko, Lawrence J. 1 Frueh, Felix W. 1 Huang, Shiew-Mei 1 Cavaille-Coll, Marc W. 2; Affiliation: 1: Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, FDA, Silver Springs, MD 2: Division of Special Pathogen and Transplant Products, Office of New Drugs, Center for Drug Evaluation and Research, FDA, Silver Springs, MD; Source Info: Feb2008, Vol. 8 Issue 2, p267; Subject Term: BIOCHEMICAL markers; Subject Term: DRUG development; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DRUG therapy; Subject Term: CLINICAL trials; Author-Supplied Keyword: Biomarker; Author-Supplied Keyword: drug development; Author-Supplied Keyword: drugs; Author-Supplied Keyword: end points; Author-Supplied Keyword: surrogate end points; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1111/j.1600-6143.2007.02063.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
AU - Woosley, Raymond
T1 - The FDA Critical Path Initiative and Its Influence on New Drug Development.
JO - Annual Review of Medicine
JF - Annual Review of Medicine
Y1 - 2008/02//
VL - 59
IS - 1
M3 - Article
SP - 1
EP - 12
SN - 00664219
AB - Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. An important part of the initiative is the use of public-private partnerships and consortia to accomplish the needed research. This article explicates the reasoning behind the Critical Path Initiative and discusses examples of successful consortia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annual Review of Medicine is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - PHARMACEUTICAL industry
KW - DRUGS -- Effectiveness
KW - PUBLIC-private sector cooperation
KW - UNITED States
KW - biomarker qualification
KW - biomarkers
KW - clinical trials
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31197434; Woodcock, Janet 1; Email Address: Janer.Woodcock@fda.hhs.gov Woosley, Raymond 2; Email Address: RWoosley@c-path.org; Affiliation: 1: Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857 2: The Critical Path Institute, Tucson, Arizona 85721; Source Info: 2008, Vol. 59 Issue 1, p1; Subject Term: DRUG development; Subject Term: PHARMACEUTICAL industry; Subject Term: DRUGS -- Effectiveness; Subject Term: PUBLIC-private sector cooperation; Subject Term: UNITED States; Author-Supplied Keyword: biomarker qualification; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: clinical trials; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 12p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1014/annurev.med.59.090506.155819
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31197434&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beaubrun, J. Jean-Gilles
AU - Kothary, M. H.
AU - Curtis, S. K.
AU - Flores, N. C.
AU - Eribo, B. E.
AU - Tall, B. D.
T1 - Isolation and Characterization of Vibrio tubiashii Outer Membrane Proteins and Determination of a toxR Homolog.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/02//
VL - 74
IS - 3
M3 - Article
SP - 907
EP - 911
SN - 00992240
AB - Outer membrane proteins (OMPs) expressed by Vibrio tubiashii under different environmental growth conditions were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and PCR analyses. Results showed the presence of a 38- to 40-kDa OmpU-like protein and ompU gene, a maltoporin-like protein, several novel OMPs, and a regulatory toxR homolog. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEMBRANE proteins
KW - BIOLOGICAL membranes
KW - VIBRIO
KW - GEL electrophoresis
KW - POLYACRYLAMIDE
KW - AMINO acids
KW - POLYMERASE chain reaction
KW - PROTEINS
KW - GENES
N1 - Accession Number: 30043144; Beaubrun, J. Jean-Gilles 1,2; Email Address: junia.beaubrun@fda.hhs.gov Kothary, M. H. 2 Curtis, S. K. 2 Flores, N. C. 2 Eribo, B. E. 1 Tall, B. D. 2; Affiliation: 1: Howard University, Washington, D.C. 20050 2: U.S. Food and Drug Administration, Laurel, Maryland 20708; Source Info: Feb2008, Vol. 74 Issue 3, p907; Subject Term: MEMBRANE proteins; Subject Term: BIOLOGICAL membranes; Subject Term: VIBRIO; Subject Term: GEL electrophoresis; Subject Term: POLYACRYLAMIDE; Subject Term: AMINO acids; Subject Term: POLYMERASE chain reaction; Subject Term: PROTEINS; Subject Term: GENES; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1128/AEM.02052-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=30043144&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rasanathan, Kumanan
AU - Ameratunga, Shanthi
AU - Tin Tin, Sandar
AU - Robinson, Elizabeth
AU - Chen, Janet
AU - Young, Wilson
AU - Watson, Peter D.
T1 - Injury risk behaviours among young Asian New Zealanders: a national survey of secondary school students.
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 2008/02//
VL - 32
IS - 1
M3 - Article
SP - 66
EP - 72
SN - 13260200
AB - Objective: To investigate injury risk behaviours among young Asian New Zealanders. Method: Secondary analysis of data from Youth2000, a nationwide cross-sectional youth health survey conducted in 2001 in a random sample of New Zealand (NZ) secondary schools using a multimedia, computer-assisted, self-administered interview. Of the 9,567 survey participants (aged 12 to 18 years), this study was restricted to students who identified with an ‘Asian’ ethnic category (n=922). Results: Many young Asian New Zealanders report engaging in injury risk behaviours, including: not using helmets when cycling; dangerous drink and drug driving; and being intentionally physically harmed by others. NZ-born Asian students are more likely than overseas-born Asian students to report most of these risky behaviours. Chinese and Indian students are less likely to engage in most of these behaviours than their NZ European peers. Conclusion: While young Asian New Zealanders are a relatively healthy population, many engage in well-recognised injury risk behaviours. The lower levels of these risky behaviours in Indian and Chinese students compared with NZ European students, and the positive dose-response effect seen in relation to duration of residence in NZ, are likely to be due to the effect of acculturation. Implications: Injury prevention strategies for young people in NZ need to specifically consider the diversity, context and specific risk profiles of young Asian New Zealanders. Health promotion efforts for this group should target the use of safety equipment and risky driving behaviours and consider traditional cultural practices that may be protective. [ABSTRACT FROM AUTHOR]
AB - Copyright of Australian & New Zealand Journal of Public Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACCIDENT prevention
KW - HEALTH surveys
KW - WOUNDS & injuries
KW - HIGH schools -- New Zealand
KW - RISK-taking (Psychology) in adolescence
KW - NEW Zealanders
KW - DRUNK driving
KW - HEALTH promotion
KW - NEW Zealand
KW - adolescent
KW - Asian Continental Ancestry Group
KW - injuries
KW - minority groups
KW - New Zealand
KW - risk taking
N1 - Accession Number: 29985068; Rasanathan, Kumanan 1; Email Address: k.rasanathan@auckland.ac.nz; Ameratunga, Shanthi 1; Tin Tin, Sandar 1; Robinson, Elizabeth 1; Chen, Janet 2; Young, Wilson 2; Watson, Peter D. 1; Affiliations: 1: University of Auckland, New Zealand.; 2: Auckland Regional Public Health Service, New Zealand.; Issue Info: Feb2008, Vol. 32 Issue 1, p66; Thesaurus Term: ACCIDENT prevention; Subject Term: HEALTH surveys; Subject Term: WOUNDS & injuries; Subject Term: HIGH schools -- New Zealand; Subject Term: RISK-taking (Psychology) in adolescence; Subject Term: NEW Zealanders; Subject Term: DRUNK driving; Subject Term: HEALTH promotion; Subject: NEW Zealand; Author-Supplied Keyword: adolescent; Author-Supplied Keyword: Asian Continental Ancestry Group; Author-Supplied Keyword: injuries; Author-Supplied Keyword: minority groups; Author-Supplied Keyword: New Zealand; Author-Supplied Keyword: risk taking; Number of Pages: 7p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1111/j.1753-6405.2008.00168.x
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sarah M. Robertson
AU - Richard T. Davey
AU - Jocelyn Voell
AU - Elizabeth Formentini
AU - Raul M. Alfaro
AU - Scott R. Penzak
T1 - Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects.
JO - Current Medical Research & Opinion
JF - Current Medical Research & Opinion
Y1 - 2008/02//
VL - 24
IS - 2
M3 - Article
SP - 591
EP - 599
SN - 03007995
AB - Objective: Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives were to compare ritonavir exposure pre- and post-GBE, and assess the effect of GBE on single doses of probe drugs midazolam and fexofenadine.Methods: This open-label study evaluated the effect of 2 weeks of standardized GBE administration on the steady-state exposure of lopinavir and ritonavir in 14 healthy volunteers administered lopinavir/ritonavir to steady-state. In addition, single oral doses of probe drugs midazolam and fexofenadine were administered prior to and after 4 weeks of GBE (following washout of lopinavir/ritonavir) to assess the influence of GBE on CYP3A and P-gp activity, respectively.Results: Lopinavir, ritonavir and fexofenadine exposures were not significantly affected by GBE administration. However, GBE decreased midazolam AUC0–∞ and Cmax by 34% (p = 0.03) and 31% (p = 0.03), respectively, relative to baseline. In general, lopinavir/ritonavir and GBE were well tolerated. Abnormal laboratory results included mild elevations in hepatic enzymes, cholesterol and triglycerides, and mild-to-moderate increases in total bilirubin.Conclusions: Our results suggest that GBE induces CYP3A metabolism, as assessed by a decrease in midazolam concentrations. However, there was no change in the exposure of lopinavir, likely due to ritonavir''s potent inhibition of CYP3A4. Thus, GBE appears unlikely to reduce the exposure of ritonavir-boosted protease inhibitors, while concentrations of unboosted protease inhibitors may be affected. Limitations to our study include the single sequence design and the evaluation of a ritonavir-boosted protease inhibitor exclusively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Current Medical Research & Opinion is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINKGO
KW - MIDAZOLAM
KW - FEXOFENADINE
KW - PHARMACOKINETICS
KW - BENZODIAZEPINES
KW - MUSCLE relaxants
KW - THERAPEUTIC use
N1 - Accession Number: 29322146; Sarah M. Robertson 1 Richard T. Davey 2 Jocelyn Voell 3 Elizabeth Formentini 3 Raul M. Alfaro 4 Scott R. Penzak 4; Affiliation: 1: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, DHHS, Silver Spring, MD, USA 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 3: Clinical Research Center, Department of Critical Care Medicine, National Institutes of Health, Bethesda, MD, USA 4: Clinical Research Center, Pharmacy Department, National Institutes of Health, Bethesda, MD, USA; Source Info: Feb2008, Vol. 24 Issue 2, p591; Subject Term: GINKGO; Subject Term: MIDAZOLAM; Subject Term: FEXOFENADINE; Subject Term: PHARMACOKINETICS; Subject Term: BENZODIAZEPINES; Subject Term: MUSCLE relaxants; Subject Term: THERAPEUTIC use; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105893323
T1 - Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects.
AU - Robertson SM
AU - Davey RT
AU - Voell J
AU - Formentini E
AU - Alfaro RM
AU - Penzak SR
Y1 - 2008/02//
N1 - Accession Number: 105893323. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 0351014.
KW - Fexofenadine -- Pharmacokinetics
KW - Ginkgo Biloba -- Metabolism
KW - Heterocyclic Compounds -- Pharmacokinetics
KW - Medicine, Herbal
KW - Midazolam -- Pharmacokinetics
KW - Plant Extracts -- Metabolism
KW - Protease Inhibitors -- Pharmacodynamics
KW - Protease Inhibitors -- Pharmacokinetics
KW - Ritonavir -- Pharmacokinetics
KW - Adult
KW - Clinical Trials
KW - Drug Interactions
KW - Female
KW - Ginkgo Biloba -- Adverse Effects
KW - Glycoproteins -- Metabolism
KW - Hemeproteins -- Metabolism
KW - Male
KW - Plant Extracts -- Adverse Effects
KW - Human
SP - 591
EP - 599
JO - Current Medical Research & Opinion
JF - Current Medical Research & Opinion
JA - CURR MED RES OPIN
VL - 24
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - OBJECTIVE: Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives were to compare ritonavir exposure pre- and post-GBE, and assess the effect of GBE on single doses of probe drugs midazolam and fexofenadine. METHODS: This open-label study evaluated the effect of 2 weeks of standardized GBE administration on the steady-state exposure of lopinavir and ritonavir in 14 healthy volunteers administered lopinavir/ritonavir to steady-state. In addition, single oral doses of probe drugs midazolam and fexofenadine were administered prior to and after 4 weeks of GBE (following washout of lopinavir/ritonavir) to assess the influence of GBE on CYP3A and P-gp activity, respectively. RESULTS: Lopinavir, ritonavir and fexofenadine exposures were not significantly affected by GBE administration. However, GBE decreased midazolam AUC(0-infinity) and C(max) by 34% (p = 0.03) and 31% (p = 0.03), respectively, relative to baseline. In general, lopinavir/ritonavir and GBE were well tolerated. Abnormal laboratory results included mild elevations in hepatic enzymes, cholesterol and triglycerides, and mild-to-moderate increases in total bilirubin. CONCLUSIONS: Our results suggest that GBE induces CYP3A metabolism, as assessed by a decrease in midazolam concentrations. However, there was no change in the exposure of lopinavir, likely due to ritonavir's potent inhibition of CYP3A4. Thus, GBE appears unlikely to reduce the exposure of ritonavir-boosted protease inhibitors, while concentrations of unboosted protease inhibitors may be affected. Limitations to our study include the single sequence design and the evaluation of a ritonavir-boosted protease inhibitor exclusively.
SN - 0300-7995
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, New Hampshire Ave., Silver Spring, MD 20901, USA. sarah.robertson@fda.hhs.gov
U2 - PMID: 18205997.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shi, Leming
AU - Perkins, Roger G
AU - Fang, Hong
AU - Tong, Weida
T1 - Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
Y1 - 2008/02//
VL - 19
IS - 1
M3 - Article
SP - 10
EP - 18
SN - 09581669
AB - Over a few short years, microarray gene expression profiling has permeated most areas of biomedical research. Microarrays are now poised to enter the more demanding realm of clinical applications. The prospect of using microarray data to derive biomarkers of disease or toxicity, predict prognosis, or select treatments raises the validity and reliability bar substantially higher. The potential future payoffs are huge in terms of faster approval of more efficacious and safer medical interventions, and a more personalized implementation of them. Arriving at the future sooner rather than later is the motivation for the FDA-led MicroArray Quality Control (MAQC) project. The widespread collaboration aims to assess achievable technical performance of microarrays and capabilities and limitations of methods for microarray data analysis. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Biotechnology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHIPS
KW - GENE expression
KW - DATA analysis
KW - BIOREACTORS
KW - MOLECULAR computers
KW - CHEMICAL reactors
N1 - Accession Number: 29958914; Shi, Leming 1; Email Address: leming.shi@fda.hhs.gov Perkins, Roger G 2 Fang, Hong 2 Tong, Weida 1; Affiliation: 1: National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA 2: ICF International Inc., 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Feb2008, Vol. 19 Issue 1, p10; Subject Term: BIOCHIPS; Subject Term: GENE expression; Subject Term: DATA analysis; Subject Term: BIOREACTORS; Subject Term: MOLECULAR computers; Subject Term: CHEMICAL reactors; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.copbio.2007.11.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauder, Christian
AU - Pedras-Vasconcelos, Joao
AU - Puig, Montserrat
AU - Verthelyi, Daniela
T1 - The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results
JO - Cytokine
JF - Cytokine
Y1 - 2008/02//
VL - 41
IS - 2
M3 - Article
SP - 182
EP - 186
SN - 10434666
AB - Abstract: RNase protection assays (RPA) employing multiprobe sets are powerful tools to simultaneously measure transcription of several different genes. We used BD Biosciences/Pharmingen’s mouse chemokine probeset mCK-5c to measure chemokine gene expression in brain and spleen tissue of mice. Depending on the RPA protocol used, we observed differences in the relative amounts of transcripts for interferon-inducible protein 10 (IP-10) and T-cell activation-3 (TCA-3). Isolation and sequencing of the IP-10 specific gene from the mCK-5c probeset revealed two nucleotide insertions in the probe that are not present in the natural IP-10 cDNA. We show that these insertions cause RNase A-dependent degradation of the protected IP-10 mRNA yielding a fragment indistinguishable in size from that specific for TCA-3, thus leading to over-interpretation of TCA-3 expression as well as underestimation of IP-10 gene expression levels. [Copyright &y& Elsevier]
AB - Copyright of Cytokine is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RIBONUCLEASES
KW - CHEMOKINES
KW - NUCLEOTIDES
KW - GENE expression
KW - Chemokines
KW - IP-10 (CXCL10)
KW - mCK-5c Multiprobe set
KW - RNase protection assay
KW - TCA-3 (CCL1)
N1 - Accession Number: 30025629; Sauder, Christian 1; Email Address: christian.sauder@fda.hhs.gov Pedras-Vasconcelos, Joao 2 Puig, Montserrat 2 Verthelyi, Daniela 2; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C-20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Division of Therapeutic Proteins, Office of Biotechnology Products, CDER, Food and Drug Administration, Bethesda, Maryland, 20892, USA; Source Info: Feb2008, Vol. 41 Issue 2, p182; Subject Term: RIBONUCLEASES; Subject Term: CHEMOKINES; Subject Term: NUCLEOTIDES; Subject Term: GENE expression; Author-Supplied Keyword: Chemokines; Author-Supplied Keyword: IP-10 (CXCL10); Author-Supplied Keyword: mCK-5c Multiprobe set; Author-Supplied Keyword: RNase protection assay; Author-Supplied Keyword: TCA-3 (CCL1); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.cyto.2007.11.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=30025629&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verhoef, Linda
AU - Depoortere, Evelyn
AU - Boxman, Ingeborg
AU - Duizer, Erwin
AU - Van Duynhoven, Yvonne
AU - Harris, John
AU - Johnsen, Christina
AU - Kroneman, Annelies
AU - Le Guyader, Soizick
AU - Lim, Wilina
AU - Maunula, Leena
AU - Meldal, Hege
AU - Ratcliff, Rod
AU - Reuter, Gábor
AU - Schreier, Eckart
AU - Siebenga, Joukje
AU - Vainio, Kirsti
AU - Varela, Carmen
AU - Vennema, Harry
AU - Koopmans, Marion
T1 - Emergence of New Norovirus Variants on Spring Cruise Ships and Prediction of Winter Epidemics.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/02//
VL - 14
IS - 2
M3 - Article
SP - 238
EP - 243
SN - 10806040
AB - In June 2006, reported outbreaks of norovirus on cruise ships suddenly increased; 43 outbreaks occurred on 13 vessels. All outbreaks investigated manifested person-to-person transmission. Detection of a point source was impossible because of limited investigation of initial outbreaks and data sharing. The most probable explanation for these outbreaks is increased norovirus activity in the community, which coincided with the emergence of 2 new GGII.4 variant strains in Europe and the Pacific. As in 2002, a new GGII.4 variant detected in the spring and summer corresponded with high norovirus activity in the subsequent winter. Because outbreaks on cruise ships are likely to occur when new variants circulate, an active reporting system could function as an early warning system. Internationally accepted guidelines are needed for reporting, investigating, and controlling norovirus illness on cruise ships in Europe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemics
KW - Epidemiology
KW - Communicable diseases
KW - Noroviruses
KW - Cruise ships
KW - Caliciviruses
N1 - Accession Number: 29990997; Verhoef, Linda 1; Email Address: linda.verhoef@rivm.nl; Depoortere, Evelyn 2; Boxman, Ingeborg 3; Duizer, Erwin 1; Van Duynhoven, Yvonne 1; Harris, John 4; Johnsen, Christina 5; Kroneman, Annelies 1; Le Guyader, Soizick 6; Lim, Wilina 7; Maunula, Leena 8; Meldal, Hege 9; Ratcliff, Rod 10; Reuter, Gábor 11; Schreier, Eckart 12; Siebenga, Joukje 1; Vainio, Kirsti 9; Varela, Carmen 13; Vennema, Harry 1; Koopmans, Marion 1; Affiliations: 1: Center for Infectious Disease Control, Bilthoven, the Netherlands; 2: European Centre for Disease Prevention and Control, Stockholm, Sweden; 3: Food and Consumer Product Safety Authority, Zutphen, the Netherlands; 4: Health Protection Agency, London, England; 5: Statens Serum Institut, Copenhagen, Denmark; 6: Institut Français pour la Recherche et l'Exploitation de la Mer, Nantes, France; 7: Public Health Laboratory Centre, Hong Kong Special Administrative Region, People's Republic of China; 8: University of Helsinki, Helsinki, Finland; 9: Norwegian Institute of Public Health, Oslo, Norway; 10: Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; 11: Baranya County Institute of State Public Health Service, Pécs, Hungary; 12: Robert Koch Institute, Berlin, Germany; 13: Instituto de Salud Carlos III, Madrid, Spain; Issue Info: Feb2008, Vol. 14 Issue 2, p238; Thesaurus Term: Epidemics; Thesaurus Term: Epidemiology; Thesaurus Term: Communicable diseases; Subject Term: Noroviruses; Subject Term: Cruise ships; Subject Term: Caliciviruses; NAICS/Industry Codes: 483112 Deep Sea Passenger Transportation; NAICS/Industry Codes: 487210 Scenic and Sightseeing Transportation, Water; Number of Pages: 6p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105725457
T1 - Integrated care for homeless people--sharing knowledge and experience in practice, education and research: results of the networking efforts to find Homeless Health Workers.
AU - van Laere I
AU - Withers J
Y1 - 2008/02//
N1 - Accession Number: 105725457. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 9204966.
KW - Health Care Delivery, Integrated -- Methods
KW - Homeless Persons
KW - Social Welfare
KW - Health Care Delivery, Integrated -- Manpower
KW - International Relations
KW - Netherlands
KW - Pennsylvania
SP - 5
EP - 6
JO - European Journal of Public Health
JF - European Journal of Public Health
JA - EUR J PUBLIC HEALTH
VL - 18
IS - 1
PB - Oxford University Press / USA
SN - 1101-1262
AD - GGD Municipal Public Health Service, Dr Valckenier Outreach Practice for Homeless People, 1000 CE Amsterdam, The Netherlands. ivlaere@ggd.amsterdam.nl
U2 - PMID: 18211914.
DO - eurpub/ckm107
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mei, Nan
AU - Hu, Jiaxiang
AU - Churchwell, Mona I.
AU - Guo, Lei
AU - Moore, Martha M.
AU - Doerge, Daniel R.
AU - Chen, Tao
T1 - Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/02//
VL - 46
IS - 2
M3 - Article
SP - 628
EP - 636
SN - 02786915
AB - Abstract: In addition to occupational exposures to acrylamide (AA), concerns about AA health risks for the general population have been recently raised due to the finding of AA in food. In this study, we evaluated the genotoxicity of AA and its metabolite glycidamide (GA) in L5178Y/Tk +/− mouse lymphoma cells. The cells were treated with 2–18mM of AA or 0.125–4mM of GA for 4h without metabolic activation. The DNA adducts, mutant frequencies and the types of mutations for the treated cells were examined. Within the dose range tested, GA induced DNA adducts of adenine and guanine [N3-(2-carbamoyl-2-hydroxyethyl)-adenine and N7-(2-carbamoyl-2-hydroxyethyl)-guanine] in a linear dose-dependent manner. The levels of guanine adducts were consistently about 60-fold higher across the dose range than those of adenine. In contrast, no GA-derived DNA adducts were found in the cells treated with any concentrations of AA, consistent with a lack of metabolic conversion of AA to GA. However, the mutant frequency was significantly increased by AA at concentrations of 12mM and higher. GA was mutagenic starting with the 2mM dose, suggesting that GA is much more mutagenic than AA. The mutant frequencies were increased with increasing concentrations of AA and GA, mainly due to an increase of proportion of small colony mutants. To elucidate the underlying mutagenic mechanism, we examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for mutants induced by AA or GA. Compared to GA induced mutations, AA induced more mutants whose LOH extended to D11Mit22 and D11Mit74, an alteration of DNA larger than half of the chromosome. Statistical analysis of the mutational spectra revealed a significant difference between the types of mutations induced by AA and GA treatments (P =0.018). These results suggest that although both AA and GA generate mutations through a clastogenic mode of action in mouse lymphoma cells, GA induces mutations via a DNA adduct mechanism whereas AA induces mutations by a mechanism not involving the formation of GA adducts. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACRYLAMIDE
KW - GENETIC toxicology
KW - TOXICOLOGY
KW - TOXINS
KW - LYMPHOMAS
KW - CANCER cells
KW - CANCER -- Risk factors
KW - Acrylamide
KW - DNA adducts
KW - Genotoxicity
KW - Glycidamide
KW - Loss of heterozygosity
N1 - Accession Number: 28079034; Mei, Nan 1; Email Address: nan.mei@fda.hhs.gov Hu, Jiaxiang 1 Churchwell, Mona I. 2 Guo, Lei 3 Moore, Martha M. 1 Doerge, Daniel R. 2 Chen, Tao 1; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States 3: Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States; Source Info: Feb2008, Vol. 46 Issue 2, p628; Subject Term: ACRYLAMIDE; Subject Term: GENETIC toxicology; Subject Term: TOXICOLOGY; Subject Term: TOXINS; Subject Term: LYMPHOMAS; Subject Term: CANCER cells; Subject Term: CANCER -- Risk factors; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Glycidamide; Author-Supplied Keyword: Loss of heterozygosity; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.fct.2007.09.093
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28079034&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trucksess, M. W.
AU - Scott, P. M.
T1 - Mycotoxins in botanicals and dried fruits: A review.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/02//
VL - 25
IS - 2
M3 - Article
SP - 181
EP - 192
PB - Taylor & Francis Ltd
SN - 19440049
AB - Botanicals are used in many countries for medicinal and general health-promoting purposes. Numerous natural occurrences of mycotoxins in botanicals and dried fruits have been reported. Aflatoxins or ochratoxin A (OTA) have been found in botanicals such as ginseng, ginger, liquorice, turmeric, and kava-kava in the USA, Spain, Argentina, India, and some other countries, while fumonisins have been found in medicinal wild plants in South Africa and in herbal tea and medicinal plants in Turkey. Zearalenone was identified in ginseng root. Dried fruits can be contaminated with aflatoxins, OTA, kojic acid, and, occasionally, with patulin or zearalenone. One main area of concern is aflatoxins in dried figs; bright greenish yellow fluorescence under ultraviolet light is associated with aflatoxin contamination. OTA in dried vine fruits (raisins, sultanas, and currants) is another concern. There are also reports of aflatoxins in raisins and OTA in dried figs, apricots, dried plums (prunes), dates, and quince. Maximum permitted levels in the European Union include 4 µg kg-1 for total aflatoxins in dried fruit intended for direct consumption and 10 µg kg-1 for OTA in dried vine fruit. This review discusses the occurrence of mycotoxins in botanicals and dried fruits and analytical issues such as sampling, sample preparation, and methods for analysis. Fungal contamination of these products, the influence of sorting, storage, and processing, and prevention are also considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycotoxicoses
KW - Mycoses
KW - Mycotoxins
KW - Ergotism
KW - Ginseng
KW - Dried dates
KW - United States
KW - Spain
KW - India
KW - Argentina
KW - aflatoxins
KW - Botanicals
KW - capsicum
KW - dried fruits
KW - figs
KW - fumonisins
KW - garlic
KW - ginger
KW - ginseng
KW - liquorice
KW - ochratoxin A
KW - raisins
N1 - Accession Number: 29998728; Trucksess, M. W. 1; Email Address: mary.trucksess@fda.hhs.gov; Scott, P. M. 2; Affiliations: 1: Food and Drug Administration, College Park, MD 20740, USA; 2: Health Canada, Ottawa, Ontario K1A 0K9, Canada; Issue Info: Feb2008, Vol. 25 Issue 2, p181; Thesaurus Term: Mycotoxicoses; Thesaurus Term: Mycoses; Thesaurus Term: Mycotoxins; Subject Term: Ergotism; Subject Term: Ginseng; Subject Term: Dried dates; Subject: United States; Subject: Spain; Subject: India; Subject: Argentina; Author-Supplied Keyword: aflatoxins; Author-Supplied Keyword: Botanicals; Author-Supplied Keyword: capsicum; Author-Supplied Keyword: dried fruits; Author-Supplied Keyword: figs; Author-Supplied Keyword: fumonisins; Author-Supplied Keyword: garlic; Author-Supplied Keyword: ginger; Author-Supplied Keyword: ginseng; Author-Supplied Keyword: liquorice; Author-Supplied Keyword: ochratoxin A; Author-Supplied Keyword: raisins; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1080/02652030701567459
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ponce, Elizabeth
AU - Khan, Ashraf A.
AU - Cheng, Chorng-Ming
AU - Summage-West, Christine
AU - Cerniglia, Carl E.
T1 - Prevalence and characterization of Salmonella enterica serovar Weltevreden from imported seafood
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008/02//
VL - 25
IS - 1
M3 - Article
SP - 29
EP - 35
SN - 07400020
AB - Abstract: During 2001–2005, 210 Salmonella enterica strains were isolated from seafood samples imported into US. Strains of S. enterica serovar Weltevreden were the most predominantly found among the 64 different serovars isolated. A total of 37 Salmonella Weltevreden isolates were characterized by pulsed-field gel electrophoresis (PFGE), plasmid profiles and antibiotic susceptibility to assess genetic diversity. Our results showed a low frequency of antibiotic resistance; 35 of the 37 isolates were sensitive to ampicillin, tetracycline, chloramphenicol, gentamicin, sulfisoxazole, streptomycin and kanamycin. Only two isolates, from samples originating in the Philippines and India, showed resistance to ampicillin and tetracycline and to streptomycin, sulfisoxazole and tetracycline, respectively. Of the 37 isolates, two isolates did not carry any plasmid and 35 isolates harbored several small and mega-plasmids. These isolates were differentiated into 10 distinct types based on plasmid profiles. Four different PFGE clusters were obtained with a genetic similarity of 66–76%. Four groups of isolates (formed by two or three isolates each) showed 100% similarity in the PFGE profiles. One of these groups included strains isolated in Vietnam in 2003, 2004 and 2005 from fish and shrimp. The other groups included strains isolated in Vietnam, Indonesia and Thailand in 2000, 2004 and 2005 from snail, shrimp and fish. Our findings show genetic diversity and temporal persistence of S. enterica serovar Weltevreden in recently monitored seafood imports. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - FOOD poisoning
KW - SALMONELLA
KW - COOKING (Seafood)
KW - Epidemiology
KW - Plasmid
KW - Pulsed-field gel electrophoresis
KW - Salmonella enterica
KW - Seafood
N1 - Accession Number: 27614883; Ponce, Elizabeth 1,2 Khan, Ashraf A. 1; Email Address: ashraf.khan@fda.hhs.gov Cheng, Chorng-Ming 3 Summage-West, Christine 1 Cerniglia, Carl E. 1; Affiliation: 1: Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Departamento de Biotecnología Marina, Km. 107 carretera Tijuana-Ensenada, Ensenada, B.C. 22860, Mexico 2: Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Food and Drug Administration, Pacific Regional Laboratory—SW, Irving, CA, USA; Source Info: Feb2008, Vol. 25 Issue 1, p29; Subject Term: ENTEROBACTERIACEAE; Subject Term: FOOD poisoning; Subject Term: SALMONELLA; Subject Term: COOKING (Seafood); Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Plasmid; Author-Supplied Keyword: Pulsed-field gel electrophoresis; Author-Supplied Keyword: Salmonella enterica; Author-Supplied Keyword: Seafood; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fm.2007.09.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nawaz, Mohamed
AU - Khan, Ashraf A.
AU - Khan, Saeed
AU - Sung, Kidon
AU - Steele, Roger
T1 - Isolation and characterization of tetracycline-resistant Citrobacter spp. from catfish
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008/02//
VL - 25
IS - 1
M3 - Article
SP - 85
EP - 91
SN - 07400020
AB - Abstract: Fifty-two tetracycline-resistant Citrobacter spp. strains were isolated from farm-raised catfish. Morphological and biochemical characteristics indicated that 38 of the 52 citrobacters were Citrobacter freundii, 7 were C. amalonaticus and 7 were C. braakii. All isolates were resistant to multiple antibiotics. Polymerase chain reaction (PCR) protocols were developed to detect the presence of 3 tetracycline-resistance genes (tetA, tetB and tetG) from Citrobacter isolates. Oligonucleotide primers specifically targeting a 967-bp region of tetB successfully amplified the PCR amplicons from (85.0%) of C. freundii strains, (71.0%) of C. amalonaticus and (57%) from C. braakii. Oligonucleotide primers specific for the detection of tetA gene amplified the 417-bp PCR amplicons from (18.0%) of tetracycline-resistant C. freundii only. The assay failed to amplify tetA genes from C. brakii or C. amalonaticus. Plasmids (2.0–16.0kb) were isolated from 14 of the 38 strains of C. freundii. Strains of C. amalonaticus and C. brakii did not contain any plasmids. Dendrogram analysis of the SpeI pulsed field gel electrophoresis (PFGE) results identified 23 distinct macrorestriction patterns (mrps) among the 36 strains of C. freundii, 3 distinct mrps among the 7 strains of C. braakii and 4 unique mrps among the 7 strains of C. amalonaticus. Our results indicate that citrobacters from catfish could serve as reservoirs of tetracycline-resistance determinants. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEREDITY
KW - GENES
KW - PLASMIDS
KW - MOBILE genetic elements
KW - Antibiotic resistance genes
KW - Catfish
KW - PCR
KW - PFGE
N1 - Accession Number: 27614889; Nawaz, Mohamed; Email Address: mohamed.nawaz@fda.hhs.gov Khan, Ashraf A. 1 Khan, Saeed 1 Sung, Kidon 1 Steele, Roger 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Feb2008, Vol. 25 Issue 1, p85; Subject Term: HEREDITY; Subject Term: GENES; Subject Term: PLASMIDS; Subject Term: MOBILE genetic elements; Author-Supplied Keyword: Antibiotic resistance genes; Author-Supplied Keyword: Catfish; Author-Supplied Keyword: PCR; Author-Supplied Keyword: PFGE; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fm.2007.07.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - Mathematical treatment of plates with colony counts outside the acceptable range
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008/02//
VL - 25
IS - 1
M3 - Article
SP - 92
EP - 98
SN - 07400020
AB - Abstract: The exclusion of plate counts outside of an acceptable range can bias the estimation of concentration. If these plates are too numerous to count (TNTC), then their microbes may be inhibited. If inhibition of the microbes on a plate is suspected, then its count may be best treated as a lower bound. When these lower bounds replace counts for some plates, the estimate and confidence interval must be calculated accordingly. Also, a measure of unusualness for plate counts is discussed. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFIDENCE intervals
KW - STATISTICAL hypothesis testing
KW - SAMPLING (Statistics)
KW - EXPECTATION-maximization algorithms
KW - Agar plates
KW - Confidence intervals
KW - EM algorithm
KW - Improb
KW - Too numerous to count (TNTC)
N1 - Accession Number: 27614890; Blodgett, Robert J. 1; Email Address: robert.blodgett@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Room 2D-011, HFS-012, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Feb2008, Vol. 25 Issue 1, p92; Subject Term: CONFIDENCE intervals; Subject Term: STATISTICAL hypothesis testing; Subject Term: SAMPLING (Statistics); Subject Term: EXPECTATION-maximization algorithms; Author-Supplied Keyword: Agar plates; Author-Supplied Keyword: Confidence intervals; Author-Supplied Keyword: EM algorithm; Author-Supplied Keyword: Improb; Author-Supplied Keyword: Too numerous to count (TNTC); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fm.2007.07.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105894148
T1 - Associations between outpatient and inpatient service use among persons with HIV infection: a positive or negative relationship?
AU - Fleishman JA
AU - Moore RD
AU - Conviser R
AU - Lawrence PB
AU - Korthuis PT
AU - Gebo KA
AU - Fleishman, John A
AU - Moore, Richard D
AU - Conviser, Richard
AU - Lawrence, Perrin B
AU - Korthuis, P Todd
AU - Gebo, Kelly A
Y1 - 2008/02//
N1 - Accession Number: 105894148. Language: English. Entry Date: 20080418. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Grant Information: R01 AA016893/AA/NIAAA NIH HHS/United States. NLM UID: 0053006.
KW - Ambulatory Care -- Utilization
KW - Antiviral Agents -- Therapeutic Use
KW - HIV Infections -- Drug Therapy
KW - Hospitalization -- Statistics and Numerical Data
KW - Office Visits -- Utilization
KW - Specialties, Medical -- Statistics and Numerical Data
KW - Adolescence
KW - Adult
KW - Antiretroviral Therapy, Highly Active -- Utilization
KW - CD4 Lymphocyte Count
KW - Continuity of Patient Care
KW - Female
KW - HIV Infections -- Transmission
KW - HIV-1
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Risk Factors
KW - Surveys
KW - Time Factors
KW - United States
KW - Human
SP - 76
EP - 95
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 43
IS - 1p2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Objective: To examine the prospective association between frequency of outpatient visits and subsequent inpatient admissions.Data Sources: Medical record data on 13,942 patients with HIV infection seen in 10 HIV speciality care sites across the United States.Study Design: This observational study followed a cohort of HIV-infected patients who were in care in the first half of 2001. Numbers of inpatient admissions and outpatient visits were calculated for each patient for each 3-month period, from 2001 through 2004.Analysis: Negative binomial and logistic regression analyses using random-effects models examined the effects of inpatient admissions and outpatient visits in the previous period on inpatient and outpatient service utilization, controlling for background characteristics and HIV disease stage.Results: For 3-month periods, between 5 and 9 percent of patients had an inpatient admission. The linear association between number of outpatient visits and any inpatient admission in the subsequent period was positive (adjusted odds ratio=1.05; 95 percent confidence interval [CI]=1.04, 1.06). However, patients with zero prior outpatient visits had significantly greater admission rates than those with one prior visit. Hospitalization rates were also higher among those with a prior hospitalization and those with more advanced HIV disease.Conclusions: These results suggest a J-shaped relationship between outpatient use and inpatient use among persons with HIV disease. Those in worse health have greater utilization of both inpatient and outpatient care. However, having no outpatient visits may also increase the likelihood of subsequent hospitalization. Although outpatient care cannot be justified as a cost-saving mechanism, maintaining regular clinical monitoring of patients is important.
SN - 0017-9124
AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA
U2 - PMID: 18211519.
DO - 10.1111/j.1475-6773.2007.00750.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hongwei Hsiao
AU - Hause, Mathew
AU - Powers Jr., John R.
AU - Tsui-Ying Kau
AU - Hendricks, Scott
AU - Simeonov, Peter I.
T1 - Effect of Scaffold End Frame Carrying Strategies on Worker Stepping Response, Postural Stability, and Perceived Task Difficulty.
JO - Human Factors
JF - Human Factors
Y1 - 2008/02//
VL - 50
IS - 1
M3 - Article
SP - 27
EP - 36
SN - 00187208
AB - Objective: This study determined the most favorable strategy for carrying scaffold end frames while minimizing the risk of injuries from being struck by an object, falling, and overexertion. Background: Scaffold erectors are at risk of high exposure to the aforementioned hazards associated with the dynamic human-scaffolding interface and work environments. Identifying an optimal work strategy can help reduce risk of injuries to the worker. Method: Three carrying methods, four types of work surfaces, two weights of scaffold frames, and three directions of stepping movement were tested in a laboratory with 18 construction workers. Results: The effects of carrying method on postural instability and task difficulty rating were significant for handling the 22-kg end frame. Response time, postural instability, and perceived task difficulty rating were significantly reduced when the 9-kg end frame was used as compared with the 22-kg frame. Conclusion: The symmetric side-carrying method was the best option for handling 22-kg scaffold end frames. A 9-kg end frame (e.g., made of reinforced lightweight materials) has the potential to reduce injury risk among scaffold handlers during their scaffold erection and dismantling jobs. Application: Scaffold erectors may want to adopt the symmetric side-carrying method as the primary technique for handling the 22-kg scaffold end frame, which is currently the one most used in the industry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCAFFOLDING
KW - WOUNDS & injuries
KW - ACCIDENT prevention
KW - RISK
KW - CONSTRUCTION workers
KW - CONSTRUCTION industry
KW - WORK environment
KW - BUILDING materials
KW - POSTURE
N1 - Accession Number: 30103229; Hongwei Hsiao 1; Email Address: hhsiao@cdc.gov Hause, Mathew 1 Powers Jr., John R. 1 Tsui-Ying Kau 1 Hendricks, Scott 1 Simeonov, Peter I. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Feb2008, Vol. 50 Issue 1, p27; Subject Term: SCAFFOLDING; Subject Term: WOUNDS & injuries; Subject Term: ACCIDENT prevention; Subject Term: RISK; Subject Term: CONSTRUCTION workers; Subject Term: CONSTRUCTION industry; Subject Term: WORK environment; Subject Term: BUILDING materials; Subject Term: POSTURE; NAICS/Industry Codes: 444190 Other Building Material Dealers; NAICS/Industry Codes: 423390 Other Construction Material Merchant Wholesalers; NAICS/Industry Codes: 416390 Other specialty-line building supplies merchant wholesalers; NAICS/Industry Codes: 416310 General-line building supplies merchant wholesalers; NAICS/Industry Codes: 236110 Residential building construction; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; Number of Pages: 10p; Document Type: Article
L3 - 10.1518/001872008X250548
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=30103229&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The Effect of Phase Cancellation on Estimates of Broadband Ultrasound Attenuation and Backscatter Coefficient in Human Calcaneus In Vitro.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2008/02//
VL - 55
IS - 2
M3 - Article
SP - 384
EP - 390
SN - 08853010
AB - Broadband ultrasound attenuation (BUA) is a clinically proven indicator of osteoporotic fracture risk. BUA measurements are typically performed in through-transmission with single-element phase sensitive (PS) receivers and therefore can be compromised by phase cancellation artifact. Phase-insensitive (PI) receivers suppress phase cancellation artifact. To study the effect of phase cancellation on BUA measurements, through-transmission measurements were performed on 16 human calcaneus samples in vitro using a two-dimensional receiver array that enabled PS and PI BUA estimation. The means plus or minus standard deviations for BUA measurements were 22.1 ± 15.8 dB/MHz (PS) and 17.6 ± 7.2 dB/MHz (PI), suggesting that, on the average, approximately 20% of PS BUA values in vitro can be attributed to phase cancellation artifact. Therefore, although cortical plates are often regarded as the primary source of phase cancellation artifact, the heterogeneity of cancellous bone in the calcaneal interior may also be a significant source. Backscatter coefficient estimates in human calcaneus that are based on PS attenuation compensation overestimate 1) average magnitude of backscatter coefficient at 500 kHz by a factor of about 1.6 ± 0.3 and 2) average exponent (n) of frequency dependence by about 0.34 ± 0.12 (where backscatter coefficient is fit to a power law form proportional to frequency to the nth power). [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC imaging
KW - ULTRASONICS
KW - FRACTURES -- Diagnosis
KW - BACKSCATTERING
KW - HEEL bone
N1 - Accession Number: 31156109; Wear, Keith A. 1; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Silver Spring, MD 20993-0002; Source Info: Feb2008, Vol. 55 Issue 2, p384; Subject Term: ULTRASONIC imaging; Subject Term: ULTRASONICS; Subject Term: FRACTURES -- Diagnosis; Subject Term: BACKSCATTERING; Subject Term: HEEL bone; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1109/TUFFC.2008.656
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105881599
T1 - Critical views in infectious disease medicine. Long-term efficacy and safety of tipranavir boosted with ritonavir.
AU - Chan-Tack KM
AU - Murray JS
AU - Birnkrant DB
Y1 - 2008/02//
N1 - Accession Number: 105881599. Language: English. Entry Date: 20080411. Revision Date: 20150711. Publication Type: Journal Article; abstract; commentary. Original Study: Markowitz M, Slater LN, Schwartz R, et al. Long-term efficacy and safety of tipranavir boosted with ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2 study. J ACQUIR IMMUNE DEFIC SYNDR 2007; 45: 401-10. Journal Subset: Biomedical. NLM UID: 8612480.
KW - Drug Therapy, Combination
KW - HIV Infections -- Drug Therapy
KW - Ritonavir -- Therapeutic Use
KW - Antiviral Agents -- Administration and Dosage
KW - Study Design
KW - Treatment Outcomes
SP - 61
EP - 62
JO - Infections in Medicine
JF - Infections in Medicine
JA - INFECT MED
VL - 25
IS - 2
CY - Greenwich, Connecticut
PB - Cliggott Publishing Company
SN - 0749-6524
AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bevilacqua, Maria Cecilia
AU - Caiuby Novaes, Beatriz
AU - Morata, Thais C.
T1 - Audiology in Brazil.
JO - International Journal of Audiology
JF - International Journal of Audiology
Y1 - 2008/02//
VL - 47
IS - 2
M3 - Article
SP - 45
EP - 50
SN - 14992027
AB - The profession of audiology took root in Brazil nearly a half a century ago and has since blossomed into a flourishing, well-developed field. Currently, audiologists in Brazil work at private institutions, including private medical practices and dedicated speech and hearing clinics. They are also employed in a wide array of public institutions, including community clinics, elementary schools, colleges, and universities. In both the private sector and health clinics, audiologists perform diagnostic evaluations of auditory and vestibular disorders, select and fit hearing aids, and provide aural rehabilitation. At the public level, they assist with workers' health programs, dispense hearing aids, and aural rehabilitation. There is always room to grow, however, and the future of audiology in Brazil holds both challenges and opportunity. The following article will sketch the development of audiology training and practice in Brazil, provide a picture of how the field stands today, and summarize the unique challenges which the profession faces in this large and diverse nation. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Audiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUDIOLOGY
KW - HEALTH facilities
KW - AUDIOLOGISTS
KW - HEARING clinics
KW - HEARING aids
KW - BRAZIL
KW - Communication disorders
KW - Developing country
KW - Hearing loss
KW - Public health
N1 - Accession Number: 28698780; Bevilacqua, Maria Cecilia 1; Email Address: cecilia@implantecoclear.com.br Caiuby Novaes, Beatriz 2 Morata, Thais C. 3,4; Affiliation: 1: Universidade de São Paulo, Centro de Pesquisas Audiológicas, Brazil 2: Pontifícia Universidade Católica de São Paulo (PUC-SP), Brazil 3: Universidade Tuiuiti do Paraná, Brazil 4: National Institute for Occupational Safety and Health, Cincinnati, USA; Source Info: Feb2008, Vol. 47 Issue 2, p45; Subject Term: AUDIOLOGY; Subject Term: HEALTH facilities; Subject Term: AUDIOLOGISTS; Subject Term: HEARING clinics; Subject Term: HEARING aids; Subject Term: BRAZIL; Author-Supplied Keyword: Communication disorders; Author-Supplied Keyword: Developing country; Author-Supplied Keyword: Hearing loss; Author-Supplied Keyword: Public health; NAICS/Industry Codes: 621340 Offices of Physical, Occupational and Speech Therapists, and Audiologists; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 622310 Specialty (except Psychiatric and Substance Abuse) Hospitals; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/14992020701770843
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28698780&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C. Özgen
T1 - Modeling and prediction of ventilation methane emissions of U.S. longwall mines using supervised artificial neural networks
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2008/02//
VL - 73
IS - 3/4
M3 - Article
SP - 371
EP - 387
SN - 01665162
AB - Abstract: Methane emissions from a longwall ventilation system are an important indicator of how much methane a particular mine is producing and how much air should be provided to keep the methane levels under statutory limits. Knowing the amount of ventilation methane emission is also important for environmental considerations and for identifying opportunities to capture and utilize the methane for energy production. Prediction of methane emissions before mining is difficult since it depends on a number of geological, geographical, and operational factors. This study proposes a principle component analysis (PCA) and artificial neural network (ANN)-based approach to predict the ventilation methane emission rates of U.S. longwall mines. Ventilation emission data obtained from 63 longwall mines in 10 states for the years between 1985 and 2005 were combined with corresponding coalbed properties, geographical information, and longwall operation parameters. The compiled database resulted in 17 parameters that potentially impacted emissions. PCA was used to determine those variables that most influenced ventilation emissions and were considered for further predictive modeling using ANN. Different combinations of variables in the data set and network structures were used for network training and testing to achieve minimum mean square errors and high correlations between measurements and predictions. The resultant ANN model using nine main input variables was superior to multilinear and second-order non-linear models for predicting the new data. The ANN model predicted methane emissions with high accuracy. It is concluded that the model can be used as a predictive tool since it includes those factors that influence longwall ventilation emission rates. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANURE gases
KW - AIR conditioning
KW - DAMPNESS in buildings
KW - METHANE
KW - Artificial neural networks
KW - Longwall mining
KW - Methane emissions
KW - Principle component analysis
KW - Ventilation
N1 - Accession Number: 28396513; Karacan, C. Özgen 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, 15236, United States; Source Info: Feb2008, Vol. 73 Issue 3/4, p371; Subject Term: MANURE gases; Subject Term: AIR conditioning; Subject Term: DAMPNESS in buildings; Subject Term: METHANE; Author-Supplied Keyword: Artificial neural networks; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Methane emissions; Author-Supplied Keyword: Principle component analysis; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.coal.2007.09.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koturbash, Igor
AU - Loree, Jonathan
AU - Kutanzi, Kristy
AU - Koganow, Clayton
AU - Pogribny, Igor
AU - Kovalchuk, Olga
T1 - In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded Spleen
JO - International Journal of Radiation Oncology, Biology, Physics
JF - International Journal of Radiation Oncology, Biology, Physics
Y1 - 2008/02//
VL - 70
IS - 2
M3 - Article
SP - 554
EP - 562
SN - 03603016
AB - Purpose: It is well accepted that irradiated cells may “forward” genome instability to nonirradiated neighboring cells, giving rise to the “bystander effect” phenomenon. Although bystander effects were well studied by using cell cultures, data for somatic bystander effects in vivo are relatively scarce. Methods and Materials: We set out to analyze the existence and molecular nature of bystander effects in a radiation target-organ spleen by using a mouse model. The animal''s head was exposed to X-rays while the remainder of the body was completely protected by a medical-grade shield. Using immunohistochemistry, we addressed levels of DNA damage, cellular proliferation, apoptosis, and p53 protein in the spleen of control animals and completely exposed and head-exposed/body bystander animals. Results: We found that localized head radiation exposure led to the induction of bystander effects in the lead-shielded distant spleen tissue. Namely, cranial irradiation led to increased levels of DNA damage and p53 expression and also altered levels of cellular proliferation and apoptosis in bystander spleen tissue. The observed bystander changes were not caused by radiation scattering and were observed in two different mouse strains; C57BL/6 and BALB/c. Conclusion: Our study proves that bystander effects occur in the distant somatic organs on localized exposures. Additional studies are required to characterize the nature of an enigmatic bystander signal and analyze the long-term persistence of these effects and possible contribution of radiation-induced bystander effects to secondary radiation carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA damage
KW - CELL death
KW - APOPTOSIS
KW - SPLEEN
KW - γH2AX
KW - Apoptosis
KW - Bystander effect
KW - Mouse model
KW - p53
KW - Proliferation
N1 - Accession Number: 28610393; Koturbash, Igor 1 Loree, Jonathan 1 Kutanzi, Kristy 1 Koganow, Clayton 1 Pogribny, Igor 2 Kovalchuk, Olga 1; Email Address: olga.kovalchuk@uleth.ca; Affiliation: 1: Department of Biological Sciences, University of Lethbridge, Alberta, Canada 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR; Source Info: Feb2008, Vol. 70 Issue 2, p554; Subject Term: DNA damage; Subject Term: CELL death; Subject Term: APOPTOSIS; Subject Term: SPLEEN; Author-Supplied Keyword: γH2AX; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Bystander effect; Author-Supplied Keyword: Mouse model; Author-Supplied Keyword: p53; Author-Supplied Keyword: Proliferation; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ijrobp.2007.09.039
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Clancy, Carolyn M.
T1 - Clinical Research Training: Scientific Literacy for the Twenty-First Century.
JO - JGIM: Journal of General Internal Medicine
JF - JGIM: Journal of General Internal Medicine
Y1 - 2008/02//
VL - 23
IS - 2
M3 - Editorial
SP - 219
EP - 220
SN - 08848734
AB - A letter to the editor is presented in response to the article on training program in clinical research, published in the February 2008 issue.
KW - LETTERS to the editor
KW - MEDICAL research
N1 - Accession Number: 32486443; Clancy, Carolyn M. 1; Email Address: carolyn.clancy@ahrq.hhs.gov; Affiliation: 1: Agency for Healthcare Research and Quality, John M Eisenberg Building, 540 Gaither Road, Rockville, MD 20850, USA; Source Info: Feb2008, Vol. 23 Issue 2, p219; Subject Term: LETTERS to the editor; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Editorial
L3 - 10.1007/s11606-007-0485-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32486443&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Apopa, Patrick L.
AU - He, Xiaoqing
AU - Ma, Qiang
T1 - Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells.
JO - Journal of Biochemical & Molecular Toxicology
JF - Journal of Biochemical & Molecular Toxicology
Y1 - 2008/02//
VL - 22
IS - 1
M3 - Article
SP - 63
EP - 76
SN - 10956670
AB - The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/pro-oxidant tert-butylhydroquinone (tBHQ) induced two forms of the Nrf2 protein in neuroblastoma cells (IMR-32), which migrated as distinctive bands on SDS-PAGE. In vitro treatment with λ phosphatase eliminated the slower migrating form and increased the amount of the faster migrating form of Nrf2. In vivo 32Pi-phosphorylation resulted in 32Pi-labeling of the Nrf2 protein in the presence of tBHQ that can be dephosphorylated by λ phosphotase, indicating that the slower migrating form is a phosphorylated Nrf2 protein and the faster form an unphosphorylated Nrf2. Unphosphorylated Nrf2 predominated in the cytoplasm, whereas the phosphorylated form preferentially localized in the nucleus. Nuclear Nrf2 can be dephosphorylated by λ phosphotase in vitro and be converted to the faster migrating form, implicating phosphorylation of Nrf2 in the cytoplasmic-nuclear translocation of the protein. Deletional analyses from both the carboxyl- and amino-ends revealed the transcription activation (TA) domains Neh4 (Nrf2-ECH homology 4) and Neh5 (Nrf2-ECH homology 5) as a major region necessary for the phosphorylation. The TA domains are characterized by the presence of multiple phosphorylation sites of casein kinase 2 (CK2). Moreover, CK2 phosphorylated the TA domains in vitro. Treatment with CK2 inhibitor 2-dimethylamino-4,5,6,7,-tetrabromo-1 H-benzimidazole (DMAT) blocked the induction of endogenous target genes of Nrf2 in cells and inhibited the TA activities of both the full length and the TA domains of Nrf2 to a large extent. Finally, phosphorylation of the TA domains correlated with the nuclear translocation of Nrf2 that was inhibited by DMAT in a concentration-dependent manner. The findings demonstrated that phosphorylation of Nrf2 at the TA domains by CK2 is an integral component of Nrf2 activation necessary for the nuclear localization and transcription activation function of Nrf2 in neuroblastoma cells. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:63-76, 2008; Published online in Wiley InterScience (). DOI 10.1002/jbt.20212 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biochemical & Molecular Toxicology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64238305; Apopa, Patrick L. 1,2; He, Xiaoqing 1; Ma, Qiang 1,2; Affiliations: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA; 2: Department of Biochemistry and Molecular Pharmacology, West Virginia University, Morgantown, WV 26505, USA; Issue Info: Feb2008, Vol. 22 Issue 1, p63; Number of Pages: 14p; Document Type: Article
L3 - 10.1002/jbt.20212
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yue, Lilly Q.
T1 - Special Issue on Medical Device Clinical Studies - Guest Editor's Note.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 1
EP - 3
PB - Taylor & Francis Ltd
SN - 10543406
AB - The guest editor discusses papers published within this special issue on medical device including one by Campbell on statistical issues concerning the evaluation of devices versus those of drugs, and another by Liu and Chow on some challenges in the assurance of accuracy and precision of in vitro diagnostic multivariate index assays (IVDMIA).
KW - MEDICAL equipment
KW - CLINICAL drug trials
N1 - Accession Number: 28016053; Yue, Lilly Q. 1; Email Address: lilly.yue@fda.hhs.gov; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p1; Subject Term: MEDICAL equipment; Subject Term: CLINICAL drug trials; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10543400701668217
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Campbell, Gregory
T1 - Statistics in the World of Medical Devices: The Contrast with Pharmaceuticals.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 4
EP - 19
PB - Taylor & Francis Ltd
SN - 10543406
AB - Medical devices play a vital role in people's lives as these products are revolutionizing medicine with breathtaking advances in both the treatment and the detection of many diseases. While a similar, primarily therapeutic, revolution is ongoing in the pharmaceutical world; the focus here is the effect this device revolution is having on the statistical world. The similarities and differences between medical devices and pharmaceutical drugs are explored in terms of their natures, industries, and how they are regulated in the U.S. and globally. Statistical issues concerning the evaluation of devices versus those of drugs are compared and contrasted. These trends are creating new challenges for the statistical world in the development and evaluation of these new medical products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - DIAGNOSIS
KW - DRUG development
KW - CLINICAL drug trials
KW - STATISTICS
KW - UNITED States
KW - Bayesian clinical trials
KW - Diagnostic test evaluation
KW - Pharmacogenomics
KW - Regulatory statistics
N1 - Accession Number: 28016052; Campbell, Gregory 1; Email Address: greg.campbell@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p4; Subject Term: MEDICAL equipment; Subject Term: DIAGNOSIS; Subject Term: DRUG development; Subject Term: CLINICAL drug trials; Subject Term: STATISTICS; Subject Term: UNITED States; Author-Supplied Keyword: Bayesian clinical trials; Author-Supplied Keyword: Diagnostic test evaluation; Author-Supplied Keyword: Pharmacogenomics; Author-Supplied Keyword: Regulatory statistics; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 16p; Document Type: Article
L3 - 10.1080/10543400701668225
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li, Heng
AU - Yue, Lilly Q.
T1 - Statistical and Regulatory Issues in Nonrandomized Medical Device Clinical Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 20
EP - 30
PB - Taylor & Francis Ltd
SN - 10543406
AB - While randomized, well-controlled, clinical trials have been viewed as the gold standard in the evaluation of medical products, it is not uncommon for medical device clinical studies to depart from the paradigm of randomized trials, due to ethical or practical reasons. In nonrandomized studies, the advantages of well-designed and conducted randomized clinical trials are no longer available, and consequently the statistical inference obtained from such studies may carry a lower level of scientific assurance, compared to randomized trials. This paper provides a brief overview of nonrandomized medical device clinical studies in terms of design and statistical analysis as well as regulatory issues, including some challenges that frequently arise in those endeavors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - CLINICAL trials
KW - STATISTICS
KW - MEDICAL policy
KW - MATHEMATICAL statistics
KW - Historical control
KW - Nonrandomized study
KW - Treatment group comparability
N1 - Accession Number: 28016051; Li, Heng 1; Email Address: heng.li@fda.hhs.gov Yue, Lilly Q. 1; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p20; Subject Term: MEDICAL equipment; Subject Term: CLINICAL trials; Subject Term: STATISTICS; Subject Term: MEDICAL policy; Subject Term: MATHEMATICAL statistics; Author-Supplied Keyword: Historical control; Author-Supplied Keyword: Nonrandomized study; Author-Supplied Keyword: Treatment group comparability; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1080/10543400701668233
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28016051&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lao, Chang S.
AU - Bushar, Harry F.
T1 - Longitudinal Data Analysis in Medical Device Clinical Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 44
EP - 53
PB - Taylor & Francis Ltd
SN - 10543406
AB - Several statistical approaches are discussed for analysis of longitudinal clinical data from a two independent groups, randomized, prospective, multicenter study of patients with benign prostate hyperplasia (BPH) who are treated with either a new transurethral microwave thermotherapy device (TUMT, n = 147) or sham control (n = 73) at baseline and at 1, 3, and 6 months follow up. The primary clinical endpoint, based on the American Urological Association (AUA) symptom score from 7 questions (each scored 0-5) with 35 as the worst total score, is illustrated in this paper. The primary effectiveness null hypothesis is no treatment effect at any follow-up time against the alternative hypothesis of a favorable treatment effect at one or more follow-up times. Based on the prespecified clinical input of TUMT improvement in AUA mean score as a possible early effect, the expected change of slope between baseline to month 1 (baseline slope) and from month 1 to the end of month 6 (longitudinal slope), with knot at one month, were analyzed. The primary effectiveness endpoint was analyzed by a piecewise linear spline regression model with knot at month 1. Statistically significant lower mean AUA score was found in the TUMT group compared to the sham group at month 3 (P = 0.01) and at month 6 (P < 0.0001) follow-up; no significant difference in mean AUA score was found at baseline or at month 1 follow-up, after an overall statistically significant difference in mean AUA score (P = 0.004) was found between the TUMT and sham groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL equipment
KW - HYPERPLASIA
KW - THERMOTHERAPY
KW - REGRESSION analysis
KW - PROSTATE
KW - Analysis of covariance (ANCOVA)
KW - Piecewise linear spline model
KW - Repeated measurements
KW - Summary statistics
N1 - Accession Number: 28016049; Lao, Chang S. 1; Email Address: chang.lao@fda.hhs.gov Bushar, Harry F. 1; Affiliation: 1: Division of Biostatistics, Office of Surveillance and Biostatistics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p44; Subject Term: MEDICAL equipment; Subject Term: HYPERPLASIA; Subject Term: THERMOTHERAPY; Subject Term: REGRESSION analysis; Subject Term: PROSTATE; Author-Supplied Keyword: Analysis of covariance (ANCOVA); Author-Supplied Keyword: Piecewise linear spline model; Author-Supplied Keyword: Repeated measurements; Author-Supplied Keyword: Summary statistics; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 10p; Illustrations: 8 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400701668258
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kondratovich, Marina V.
T1 - Comparing Two Medical Tests When Results of Reference Standard Are Unavailable for Those Negative via Both Tests.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 145
EP - 166
PB - Taylor & Francis Ltd
SN - 10543406
AB - In studies for comparing the diagnostic accuracy of two qualitative tests, very often the reference standard to confirm the disease status is not applied to all study subjects. We considered a situation when all subjects with a positive result by at least one of the tests had a verified disease status and none of the subjects with both tests negative results had a verification of disease status. In this paper, we discuss whether the information about the ratio of true positive rates and the ratio of false positive rates of two qualitative tests, TNew and TOld, is sufficient to draw a conclusion about effectiveness of the TNew. We show that if there is a statistically significant increase in true positive rates and the increase in true positive rates is statistically larger than increase in false positive rates, then a conclusion about effectiveness of test TNew can be made and this does not require application of the reference standard to the subjects with negative results by both tests. An application of ratio of true positive rates and ratio of false positive rates to post-market studies is also presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIAGNOSIS
KW - CLINICAL medicine
KW - MEDICAL screening
KW - CLINICAL pathology
KW - STANDARDS
KW - Diagnostic accuracy
KW - Missing values
KW - Multiple imputation
KW - Ratio of false positive rates
KW - Ratio of true positive rates
KW - Verification bias
N1 - Accession Number: 28016059; Kondratovich, Marina V. 1; Email Address: Marina.Kondratovich@fda.hhs.gov; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p145; Subject Term: DIAGNOSIS; Subject Term: CLINICAL medicine; Subject Term: MEDICAL screening; Subject Term: CLINICAL pathology; Subject Term: STANDARDS; Author-Supplied Keyword: Diagnostic accuracy; Author-Supplied Keyword: Missing values; Author-Supplied Keyword: Multiple imputation; Author-Supplied Keyword: Ratio of false positive rates; Author-Supplied Keyword: Ratio of true positive rates; Author-Supplied Keyword: Verification bias; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 22p; Illustrations: 1 Diagram, 8 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/10543400701668308
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lababidi, Samir
T1 - Challenges in DNA Microarray Studies from the Regulatory Perspective.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 183
EP - 202
PB - Taylor & Francis Ltd
SN - 10543406
AB - Genomic classifiers using DNA microarrays are becoming powerful tools in the medical community with the potential to revolutionize the diagnosis and treatment of disease. However, despite the tremendous interest in using these classifiers in diagnosis and the management of disease, few genomic classifiers have made it into clinical practice. Some of the major challenges for the development and validation of genomic classifiers will be discussed in this article together with some of their difficulties. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - BIOCHIPS
KW - GENOMICS
KW - DIAGNOSIS
KW - THERAPEUTICS
KW - Classifiers
KW - Microarrays
KW - Normalization
KW - Prediction accuracy
KW - Reproducibility
N1 - Accession Number: 28016057; Lababidi, Samir 1; Email Address: samir.lababidi@fda.hhs.gov; Affiliation: 1: CDRH, U.S. Food and Drug Administration, Rockville, Maryland, USA; Source Info: Feb2008, Vol. 18 Issue 1, p183; Subject Term: DNA microarrays; Subject Term: BIOCHIPS; Subject Term: GENOMICS; Subject Term: DIAGNOSIS; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Classifiers; Author-Supplied Keyword: Microarrays; Author-Supplied Keyword: Normalization; Author-Supplied Keyword: Prediction accuracy; Author-Supplied Keyword: Reproducibility; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 20p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1080/10543400701668324
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donald E. Eggerth
T1 - From Theory of Work Adjustment to Person–Environment Correspondence Counseling: Vocational Psychology as Positive Psychology.
JO - Journal of Career Assessment
JF - Journal of Career Assessment
Y1 - 2008/02//
VL - 16
IS - 1
M3 - Article
SP - 60
EP - 74
SN - 10690727
AB - This article argues that vocational psychology is, and has been, positive psychology. It provides an overview of the theory of work adjustment (TWA), one of the most robust and best validated theories in vocational psychology. It also provides an introduction to person-environment-correspondence (PEC) counseling, an extension of the TWA concepts and dynamics into the realm of general counseling. Linkages are made between the extensive TWA literature and current conceptualizations regarding well-being. In particular, TWA is related to the work of Moos, Ryan and Deci, and Walsh. Although PEC has yet to generate the research base of TWA, it is argued that, given the similarities between TWA and PEC, one might reasonably expect that many of the connections between TWA and well-being would also generalize to PEC. In addition, it is argued that PEC offers a counseling model that is in keeping with the broader philosophical orientation of positive psychology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Career Assessment is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITY of work life
KW - PERSONALITY development
KW - POSITIVE psychology
KW - HELPING behavior
N1 - Accession Number: 28227845; Donald E. Eggerth 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; Source Info: Feb2008, Vol. 16 Issue 1, p60; Subject Term: QUALITY of work life; Subject Term: PERSONALITY development; Subject Term: POSITIVE psychology; Subject Term: HELPING behavior; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cunningham, William C.
T1 - Study of cryogenic procedures for preparation of food for element analysis
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2008/02//
VL - 21
IS - 1
M3 - Article
SP - 35
EP - 44
SN - 08891575
AB - Abstract: Two cryogenic homogenization procedures, Teflon disk milling and stainless-steel impact milling, were studied for preparing food and dietary supplements for element analysis. The functionality of the disk mill was demonstrated for a fruit/nut/oatmeal granola. Improvement over a rotary cutter blending procedure was shown for three fast-food type foods—hamburger, fried chicken, and egg/ham/cheese English muffin. The capabilities of the two procedures to process mixtures comprised of very dissimilar components were compared. The mixtures included a commercial hard candy having a chili powder coating and a 50:50 (by mass) combination of choline tablets and echinacea root capsules. Nonhomogeneities were found by calculating relative standard deviations (RSDs) for replicate analyses (n=5) and comparing them with the random uncertainties associated with the measurements. Analytical portion masses ranged between 1g and 45mg. Element mass fractions were determined using instrumental neutron activation analysis. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOW temperature engineering
KW - STAINLESS steel
KW - FOOD -- Analysis
KW - FOOD -- Composition
KW - Cryogenic homogenization
KW - Element analysis
KW - Food analysis
KW - Homogeneity
KW - Neutron activation analysis
N1 - Accession Number: 27334354; Cunningham, William C. 1; Email Address: william.cunningham@fda.hhs.gov; Affiliation: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Chemical Contaminants Branch (HFS-716), 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Feb2008, Vol. 21 Issue 1, p35; Subject Term: LOW temperature engineering; Subject Term: STAINLESS steel; Subject Term: FOOD -- Analysis; Subject Term: FOOD -- Composition; Author-Supplied Keyword: Cryogenic homogenization; Author-Supplied Keyword: Element analysis; Author-Supplied Keyword: Food analysis; Author-Supplied Keyword: Homogeneity; Author-Supplied Keyword: Neutron activation analysis; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jfca.2007.07.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jackson, Lauren S.
AU - Al-Taher, Fadwa M.
AU - Moorman, Mark
AU - Devries, Jonathan W.
AU - Tippett, Roger
AU - Swanson, Katherine M. J.
AU - Tong-Jen Fu
AU - Salter, Robert
AU - Dunaif, George
AU - Estes, Susan
AU - Albillos, Silvia
AU - Gendel, Steven M.
T1 - Cleaning and Other Control and Validation Strategies To Prevent Allergen Cross-Contact in Food-Processing Operations.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/02//
VL - 71
IS - 2
M3 - Article
SP - 445
EP - 458
SN - 0362028X
AB - Food allergies affect an estimated 10 to 12 million people in the United States. Some of these individuals can develop life-threatening allergic reactions when exposed to allergenic proteins. At present, the only successful method to manage food allergies is to avoid foods containing allergens. Consumers with food allergies rely on food labels to disclose the presence of allergenic ingredients. However, undeclared allergens can be inadvertently introduced into a food via cross-contact during manufacturing. Although allergen removal through cleaning of shared equipment or processing lines has been identified as one of the critical points for effective allergen control, there is little published information on the effectiveness of cleaning procedures for removing allergenic materials from processing equipment. There also is no consensus on how to validate or verify the efficacy of cleaning procedures. The objectives of this review were (i) to study the incidence and cause of allergen cross-contact, (ii) to assess the science upon which the cleaning of food contact surfaces is based, (iii) to identify best practices for cleaning allergenic foods from food contact surfaces in wet and dry manufacturing environments, and (iv) to present best practices for validating and verifying the efficacy of allergen cleaning protocols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergens
KW - Food
KW - Food allergy
KW - Food industry
KW - United States
N1 - Accession Number: 31126222; Jackson, Lauren S. 1; Email Address: lauren.jackson@fda.hhs.gov; Al-Taher, Fadwa M. 2; Moorman, Mark 3; Devries, Jonathan W. 4; Tippett, Roger 5; Swanson, Katherine M. J. 5; Tong-Jen Fu 1; Salter, Robert 6; Dunaif, George 7; Estes, Susan 8; Albillos, Silvia 2; Gendel, Steven M. 9; Affiliations: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501; 2: Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501; 3: Kellogg Company, 235 Porter Street, Battle Creek, Michigan 49014; 4: Medallion Laboratories Division, General Mills, Inc., James Ford Bell Technical Center, 9000 Plymouth Avenue North, Minneapolis, Minnesota 55427; 5: Ecolab, Inc., 655 Lone Oak Drive, Eagan, Minnesota 55121; 6: Charm Sciences, Inc., 659 Andover Street, Lawrence, Massachusetts 01843; 7: Toxicology and Analytical Services, Campbell Soup Company, Box 44-K, Camden, New Jersey 08103; 8: Pepsico, Inc., 617 West Main Street, Barrington, Illinois 60010; 9: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Feb2008, Vol. 71 Issue 2, p445; Thesaurus Term: Allergens; Thesaurus Term: Food; Thesaurus Term: Food allergy; Thesaurus Term: Food industry; Subject: United States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; Number of Pages: 14p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weagant, Stephen D.
T1 - A new chromogenic agar medium for detection of potentially virulent Yersinia enterocolitica
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2008/02//
VL - 72
IS - 2
M3 - Article
SP - 185
EP - 190
SN - 01677012
AB - Abstract: Several outbreaks of foodborne yersiniosis have been documented and this disease continues to be source of infections transmitted through foods. The selective agars most commonly used to isolate Yersinia enterocolitica in clinical, food and environmental samples, cefsulodin–irgasan–novobiocin (CIN) and MacConkey (MAC) agars, lack the ability to differentiate potentially virulent Y. enterocolitica from other Yersinia that may be present as well as some other bacterial spp. This study proposes the use of an agar medium, Y. enterocolitica chromogenic medium (YeCM), for isolation of potentially virulent Y. enterocolitica. This agar contains cellobiose as the fermentable sugar, a chromogenic substrate and selective inhibitors for suppression of colony formation by many competing bacteria. All strains of potentially virulent Yersinia of biotypes 1B, and biotypes 2-5 formed convex, red bulls-eye colonies on YeCM that were very similar to those described for CIN agar. However, Y. enterocolitica biotype 1A and other related Yersinia formed colonies that were purple/blue on YeCM while they formed typical red bulls-eye colonies on CIN agar. When a mixture of potentially virulent Y. enterocolitica biotype 1B, Y. enterocolitica biotype 1A and 5 other bacterial species was used to artificially contaminate tofu and then spread-plated on three selective agars, Y. enterocolitica biotype 1B colonies were easily distinguished from other strains on YeCM. However, Y. enterocolitica biotype 1B colonies were indistinguishable from many other colonies on CIN and only distinguishable from those of C. freundii on MAC. When colonies were picked and identified from these agars, typical colonies from YeCM were confirmed only as Y. enterocolitica biotype 1B. Typical colonies on CIN and MAC were found to belong to several competing species and biotypes. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SULFATES
KW - POLYSACCHARIDES
KW - IMPERIALISM
KW - ALGAE
KW - Agar
KW - Biotypes
KW - Chromogenic
KW - Food
KW - Virulent
KW - Y. enterocolitic
N1 - Accession Number: 28402851; Weagant, Stephen D. 1; Email Address: steve.weagant@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Pacific Regional Laboratory Northwest, Bothell, WA 98021-4421, 22201 23rd Dr. S. E., Bothell, WA 98021-4421, United States; Source Info: Feb2008, Vol. 72 Issue 2, p185; Subject Term: SULFATES; Subject Term: POLYSACCHARIDES; Subject Term: IMPERIALISM; Subject Term: ALGAE; Author-Supplied Keyword: Agar; Author-Supplied Keyword: Biotypes; Author-Supplied Keyword: Chromogenic; Author-Supplied Keyword: Food; Author-Supplied Keyword: Virulent; Author-Supplied Keyword: Y. enterocolitic; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.mimet.2007.11.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Biagini, Raymond E.
AU - Smith, Jerry P.
AU - Sammons, Deborah L.
AU - MacKenzie, Barbara A.
AU - Striley, Cynthia A. F.
AU - Robertson, Shirley K.
AU - Snawder, John E.
T1 - Analytical Performance Criteria.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/02//
VL - 5
IS - 2
M3 - Article
SP - 25
EP - 32
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents information related to immunoassays, which are based on the formation and detection of immune complexes between antigens and antibodies, and are commonly used analytical techniques for clinical diagnostic measurements, drug screening, and measurements for evaluating exposure to environmental agents. As reported, immunoassays are being used by environmental chemists in a variety of fields because of their low cost, speed, and portability. It is also reported that one of the immunoassay format, the lateral flow immunochromatographic assay (LFIA or LFA) is used for the detection of antiprotective antigen (PA) IgG from vaccination with the U.S. anthrax vaccine.
KW - Antigens
KW - Immunology
KW - Chemists
KW - Vaccination
KW - Bacterial diseases
KW - Immunoassay
KW - Immunoglobulins
KW - Blood proteins
KW - Preventive medicine
KW - Immune complexes
N1 - Accession Number: 32092791; Biagini, Raymond E. 1; Smith, Jerry P. 1; Sammons, Deborah L. 1; MacKenzie, Barbara A. 1; Striley, Cynthia A. F. 1; Robertson, Shirley K. 1; Snawder, John E. 1; Affiliations: 1: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.; Issue Info: Feb2008, Vol. 5 Issue 2, p25; Thesaurus Term: Antigens; Thesaurus Term: Immunology; Thesaurus Term: Chemists; Thesaurus Term: Vaccination; Thesaurus Term: Bacterial diseases; Subject Term: Immunoassay; Subject Term: Immunoglobulins; Subject Term: Blood proteins; Subject Term: Preventive medicine; Subject Term: Immune complexes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 6 Diagrams; Document Type: Article
L3 - 10.1080/15459620701798182
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wu, Huiquan
AU - Heilweil, Edwin J.
AU - Hussain, Ajaz S.
AU - Khan, Mansoor A.
T1 - Process analytical technology (PAT): Quantification approaches in terahertz spectroscopy for pharmaceutical application.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/02//
VL - 97
IS - 2
M3 - Article
SP - 958
EP - 971
SN - 00223549
AB - Terahertz (THz) spectroscopy and chemometric analysis of resultant absorption spectra in the 30–500 cm-1 range has been applied to perform quantitative determination of both active ingredient and excipient concentrations of tablets. Tests were performed on a series of tablets composed of various concentrations and processes of theophylline formulated with lactose, magnesium stearate, starch or Avicel, and as a function of tablet hardness. Transmission spectra of polyethylene pellets derived from each of the samples were analyzed using three approaches. Spectral superposition method was used as an indirect measure to examine whether and when the interaction among various pharmaceutical components and the tableting history could be considered insignificant for quantification purpose. Spectral characteristic peak method was able to correlate peak maxima with correction for tablets having the same hardness. Multivariate analysis (PCR and PLS 1) was capable of correlating THz spectra with tablet concentrations. The predicted concentrations of independent samples using multivariate models agreed well with nominal concentrations. The best correlations were obtained using multivariate analysis. With these studies, the advantage of using multivariate approach was demonstrated for process analytical technology (PAT) application. Further, the feasibility of integrating THz spectroscopy and chemometrics for the purpose of quantifying pharmaceutical tablet concentrations was demonstrated. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 958–971, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLXANTHINES
KW - METHYL groups
KW - CARDIOVASCULAR agents
KW - MULTIVARIATE analysis
KW - THEOPHYLLINE
KW - LACTOSE
KW - chemometrics
KW - excipients
KW - interaction
KW - multivariate analysis
KW - partial least squares
KW - process analytical technology (PAT)
KW - spectral preprocessing algorithms
KW - spectral superposition
KW - terahertz spectroscopy
KW - univariate method
N1 - Accession Number: 28021482; Wu, Huiquan 1; Email Address: huiquan.wu@fda.hhs.gov Heilweil, Edwin J. 2 Hussain, Ajaz S. 3 Khan, Mansoor A. 1; Affiliation: 1: Division of Product Quality Research (DPQR, HFD-940), Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Life Science Building 64, FDA White Oak Campus, 10903 New Hampshire Ave, Silver Spring, Maryland 20993-0002 2: Optical Technology Division, Physics Laboratory, National Institute of Standards and Technology, Maryland 3: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland; Source Info: Feb2008, Vol. 97 Issue 2, p958; Subject Term: METHYLXANTHINES; Subject Term: METHYL groups; Subject Term: CARDIOVASCULAR agents; Subject Term: MULTIVARIATE analysis; Subject Term: THEOPHYLLINE; Subject Term: LACTOSE; Author-Supplied Keyword: chemometrics; Author-Supplied Keyword: excipients; Author-Supplied Keyword: interaction; Author-Supplied Keyword: multivariate analysis; Author-Supplied Keyword: partial least squares; Author-Supplied Keyword: process analytical technology (PAT); Author-Supplied Keyword: spectral preprocessing algorithms; Author-Supplied Keyword: spectral superposition; Author-Supplied Keyword: terahertz spectroscopy; Author-Supplied Keyword: univariate method; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; Number of Pages: 14p; Illustrations: 9 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/jps.21004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105862016
T1 - Nationwide Evaluation of X-Ray Trends.
AU - Spelic DC
Y1 - 2008/02//
N1 - Accession Number: 105862016. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 101190326.
KW - Practice Patterns -- Statistics and Numerical Data
KW - Practice Patterns -- Trends
KW - Radiation Monitoring
KW - Radiography -- Statistics and Numerical Data
KW - Radiography -- Trends
KW - Surveys
KW - United States
SP - 146
EP - 148
JO - Journal of the American College of Radiology
JF - Journal of the American College of Radiology
JA - J AM COLL RADIOL
VL - 5
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1546-1440
AD - US Food and Drug Administration, Division of Mammography Quality and Radiation Programs, 1350 Piccard Drive, HFZ-240, Rockville, MD 20850, USA. david.spelic@fda.hhs.gov
U2 - PMID: 18242533.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, Robert E.
AU - Luchtefeld, Ron
T1 - An Evaluation of the Determination of the Lipophilicity of Apocyin and Diapocynin using HPLC.
JO - LC-GC Europe
JF - LC-GC Europe
Y1 - 2008/02//
VL - 21
IS - 2
M3 - Article
SP - 103
EP - 107
PB - Advanstar Communications Inc.
SN - 14716577
AB - This study evaluates the use of HPLC to estimate the log P (the octanol-water partition coefficient) of two compounds, apocynin and diapocynin. The paper will discuss the effects of an unexpected reversal of retention that occurred when these compounds were chromatographed with various amounts of methanol-water mobile phases. [ABSTRACT FROM AUTHOR]
AB - Copyright of LC-GC Europe is the property of Advanstar Communications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - METHANOL
KW - OCTYL alcohol
KW - DRUG lipophilicity
KW - PARTITION coefficient (Chemistry)
N1 - Accession Number: 29299288; Smith, Robert E. 1,2 Luchtefeld, Ron 1; Affiliation: 1: Total Diet and Pesticide Research Center, US Food and Drug Administration, Lenexa, Kansas, USA 2: Park University, Parkville, Missouri, USA; Source Info: Feb2008, Vol. 21 Issue 2, p103; Subject Term: HIGH performance liquid chromatography; Subject Term: METHANOL; Subject Term: OCTYL alcohol; Subject Term: DRUG lipophilicity; Subject Term: PARTITION coefficient (Chemistry); NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Robert E.
AU - Luchtefeld, Ron
T1 - An Evaluation of the Determination of the Lipophilicity of Apocyin and Diapocynin using HPLC.
JO - LC-GC Europe
JF - LC-GC Europe
Y1 - 2008/02//
VL - 21
IS - 2
M3 - Article
SP - 103
EP - 107
PB - Advanstar Communications Inc.
SN - 14716577
N1 - Accession Number: 29299288; Smith, Robert E. 1,2; Luchtefeld, Ron 1; Affiliations: 1: Total Diet and Pesticide Research Center, US Food and Drug Administration, Lenexa, Kansas, USA; 2: Park University, Parkville, Missouri, USA; Issue Info: Feb2008, Vol. 21 Issue 2, p103; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Konetzka, R. Tamara
AU - Spector, William
AU - Limcangco, M. Rhona
T1 - Reducing Hospitalizations From Long-Term Care Settings.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2008/02//
VL - 65
IS - 1
M3 - Article
SP - 40
EP - 66
SN - 10775587
AB - Hospital spending represents approximately one third of total national health spending, and the majority of hospital spending is by public payers. Elderly individuals with long-term care needs are at particular risk for hospitalization. While some hospitalizations are unavoidable, many are not, and there may be benefits to reducing hospitalizations in terms of health and cost. This article reviews the evidence from 55 peer-reviewed articles on interventions that potentially reduce hospitalizations from formal long-term care settings. The interventions showing the strongest potential are those that increase skilled staffing, especially through physician assistants and nurse practitioners; improve the hospital-to-home transition; substitute home health care for selected hospital admissions; and align reimbursement policies such that providers do not have a financial incentive to hospitalize. Much of the evidence is weak and could benefit from improved research design and methodology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL care
KW - LONG-term care of the sick
KW - MEDICAL care costs
KW - NURSING care facilities
KW - HOME care services
KW - home health care
KW - hospitalization
KW - intervention
KW - long-term care
KW - nursing home
N1 - Accession Number: 28532521; Konetzka, R. Tamara 1 Spector, William 2 Limcangco, M. Rhona 3; Affiliation: 1: University of Chicago 2: Agency for Healthcare Research and Quality, Rockville, Maryland 3: Social & Scientific Systems, Silver Spring, Maryland; Source Info: Feb2008, Vol. 65 Issue 1, p40; Subject Term: HOSPITAL care; Subject Term: LONG-term care of the sick; Subject Term: MEDICAL care costs; Subject Term: NURSING care facilities; Subject Term: HOME care services; Author-Supplied Keyword: home health care; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: intervention; Author-Supplied Keyword: long-term care; Author-Supplied Keyword: nursing home; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); Number of Pages: 27p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tain, You-Lin
AU - Muller, Veronika
AU - Szabo, Attila J
AU - Erdely, Aaron
AU - Smith, Cheryl
AU - Baylis, Chris
T1 - Renal cortex neuronal nitric oxide synthase in response to rapamycin in kidney transplantation
JO - Nitric Oxide
JF - Nitric Oxide
Y1 - 2008/02//
VL - 18
IS - 1
M3 - Article
SP - 80
EP - 86
SN - 10898603
AB - Abstract: Decreased renal neuronal nitric oxide synthase (nNOS) is present in various chronic kidney diseases although there is relative little known in chronic allograft nephropathy (CAN). Female sex increases the risk of acute rejection and calcineurin-inhibitor toxicity but decreases the risk of CAN. Rapamycin (RAPA) is an alternative immunosuppress although there is no information whether it is effective in females. We therefore investigated the efficacy of RAPA in both sexes and the impact of RAPA on renal cortex structure and nNOS expression. Male (M) and female (F) F344 kidneys were transplanted into same sex Lewis (ALLO) or F344 (ISO) recipients and treated with 1.6mg/kg/day of RAPA for 10 days. Grafts were removed for renal histology and endothelial (e)NOS and neuronal (n)NOS protein measurements at 22 weeks. All ALLO rats survived without acute rejection. ALLO F survived with mild proteinuria and CAN at 22 weeks similar to ALLO M, while ISO F had better outcome than ISO M. Cortical nNOSα was undetectable in all RAPA groups; however, nNOSβ transcript and protein were compensatory increased. Both ALLO and ISO F showed higher medullary nNOSα but lower cortical eNOS abundance than M groups. In male ALLO RAPA decreased renal cortical nNOSα but increased nNOSβ expression. This may represent compensatory upregulation of nNOSβ when nNOSα-derived NO is deficient. [Copyright &y& Elsevier]
AB - Copyright of Nitric Oxide is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KIDNEY transplants
KW - KIDNEY diseases -- Diagnosis
KW - NITRIC oxide
KW - CLINICAL chemistry
KW - Chronic allograft nephropathy
KW - Immunosuppression
KW - Kidney transplant
KW - Neuronal nitric oxide synthase
N1 - Accession Number: 28112362; Tain, You-Lin 1,2 Muller, Veronika 3 Szabo, Attila J 4 Erdely, Aaron 5 Smith, Cheryl 1 Baylis, Chris 1,6; Email Address: baylisc@ufl.edu; Affiliation: 1: Department of Physiology and Functional Genomics, 1600 SW Archer Road, Room M544, University of Florida, POB 100274, Gainesville, FI 32667, USA 2: Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan 3: Department of Pulmonology, Semmelweis University, Budapest, Hungary 4: Department of Pediatrics, Semmelweis University, Budapest, Hungary 5: Toxicology and Molecular Biology Branch, National Institute of Occupational Safety and Health, Morgantown, WV, USA 6: Department of Medicine, University of Florida, Gainesville, FI 32667, USA; Source Info: Feb2008, Vol. 18 Issue 1, p80; Subject Term: KIDNEY transplants; Subject Term: KIDNEY diseases -- Diagnosis; Subject Term: NITRIC oxide; Subject Term: CLINICAL chemistry; Author-Supplied Keyword: Chronic allograft nephropathy; Author-Supplied Keyword: Immunosuppression; Author-Supplied Keyword: Kidney transplant; Author-Supplied Keyword: Neuronal nitric oxide synthase; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.niox.2007.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105865310
T1 - Device safety. Prevent life-threatening communication breakdowns.
AU - Sullivan R
AU - Ferriter A
Y1 - 2008/02//
N1 - Accession Number: 105865310. Language: English. Entry Date: 20080321. Revision Date: 20150820. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 7600137.
KW - Defibrillators, Implantable
KW - Equipment Safety
KW - Perioperative Care
KW - Treatment Errors
KW - Electromagnetic Fields
KW - Male
KW - Middle Age
KW - Surgical Patients
SP - 17
EP - 17
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-consultant, Center for Devices and Radiological Health
U2 - PMID: 18223402.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105878634
T1 - Bariatric surgery: what women need to know.
AU - Clancy CM
Y1 - 2008/02//
N1 - Accession Number: 105878634. Language: English. Entry Date: 20080404. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Perioperative Care; Women's Health. NLM UID: 101304602.
KW - Bariatric Surgery
KW - Obesity -- Surgery
KW - Female
KW - Information Resources
KW - Nursing Role
KW - Patient Selection
KW - Risk Assessment
KW - Treatment Outcomes
KW - World Wide Web
SP - 21
EP - 24
JO - Nursing for Women's Health
JF - Nursing for Women's Health
JA - NURS WOMENS HEALTH
VL - 12
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1751-4851
AD - Director, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 18257882.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Bariatric Surgery: What Women Need to Know.
JO - Nursing for Women's Health
JF - Nursing for Women's Health
Y1 - 2008/02//
VL - 12
IS - 1
M3 - Article
SP - 21
EP - 24
SN - 17514851
AB - The article focuses on the obesity epidemic in the United States. Some of the methods in preventing obesity are discussed including diet, exercise and counseling. Weight-loss surgery or bariatric surgery has been demonstrated as a successful method of achieving dramatic weight loss among the morbidly obese.
KW - NUTRITION disorders
KW - OBESITY -- Surgery
KW - DIET
KW - HEALTH
KW - WEIGHT loss
N1 - Accession Number: 28785367; Clancy, Carolyn M. 1; Source Information: Feb2008, Vol. 12 Issue 1, p21; Subject: NUTRITION disorders; Subject: OBESITY -- Surgery; Subject: DIET; Subject: HEALTH; Subject: WEIGHT loss; Number of Pages: 4p; Illustrations: 3 Color Photographs; Document Type: Article
L3 - 10.1111/j.1751-486X.2007.00271.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Rasnake, Crystal M.
AU - Trumbo, Paula R.
AU - Heinonen, Therese M.
T1 - Surrogate endpoints and emerging surrogate endpoints for risk reduction of cardiovascular disease.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008/02//
VL - 66
IS - 2
M3 - Article
SP - 76
EP - 81
SN - 00296643
AB - This article reviews surrogate endpoints and emerging biomarkers that were discussed at the annual “ Cardiovascular Biomarkers and Surrogate Endpoints” symposium cosponsored by the US Food and Drug Administration (FDA) and the Montreal Heart Institute. The FDA's Center for Food Safety and Applied Nutrition (CFSAN) uses surrogate endpoints in its scientific review of a substance/disease relationship for a health claim. CFSAN currently recognizes three validated surrogate endpoints: blood pressure, blood total cholesterol, and blood low-density lipoprotein (LDL) concentration in its review of a health claim for cardiovascular disease (CVD). Numerous potential surrogate endpoints of CVD are being evaluated as the pathophysiology of heart disease is becoming better understood. However, these emerging biomarkers need to be validated as surrogate endpoints before they are used by CFSAN in the evaluation of a CVD health claim. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Safety measures
KW - Biochemical markers
KW - Cardiovascular diseases
KW - Heart diseases
KW - Blood pressure
KW - Blood cholesterol
KW - United States
KW - biomarkers
KW - cardiovascular disease
KW - health claims
KW - surrogate endpoint
KW - Center for Food Safety & Applied Nutrition (U.S.)
KW - United States. Food & Drug Administration
N1 - Accession Number: 33538076; Rasnake, Crystal M. 1; Email Address: crystal.rasnake@fda.hhs.gov; Trumbo, Paula R. 1; Heinonen, Therese M. 2; Affiliations: 1: Nutrition Programs Staff, US Food and Drug Administration, College Park, Maryland, USA; 2: Montreal Heart Institute Coordinating Center, Montreal, Quebec, Canada; Issue Info: Feb2008, Vol. 66 Issue 2, p76; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Biochemical markers; Subject Term: Cardiovascular diseases; Subject Term: Heart diseases; Subject Term: Blood pressure; Subject Term: Blood cholesterol; Subject: United States; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: health claims; Author-Supplied Keyword: surrogate endpoint ; Company/Entity: Center for Food Safety & Applied Nutrition (U.S.) ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1753-4887.2007.00010.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105729287
T1 - Surrogate endpoints and emerging surrogate endpoints for risk reduction of cardiovascular disease.
AU - Rasnake CM
AU - Trumbo PR
AU - Heinonen TM
Y1 - 2008/02//
N1 - Accession Number: 105729287. Language: English. Entry Date: 20080530. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 0376405.
KW - Biological Markers -- Blood
KW - Cardiovascular Diseases -- Prevention and Control
KW - Cardiovascular Risk Factors -- Prevention and Control
KW - Blood Pressure
KW - Cholesterol -- Blood
KW - Food Labeling
KW - Inflammation
KW - Lipoproteins -- Blood
KW - Lipoproteins, LDL Cholesterol -- Blood
KW - Oxidative Stress
KW - United States
KW - United States Food and Drug Administration
SP - 76
EP - 81
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 66
IS - 2
PB - Oxford University Press / USA
SN - 0029-6643
AD - Nutrition Programs Staff, US Food and Drug Administration, College Park, Maryland, USA.
U2 - PMID: 18254873.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105729847
T1 - FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia.
AU - Demko S
AU - Summers J
AU - Keegan P
AU - Pazdur R
Y1 - 2008/02//
N1 - Accession Number: 105729847. Language: English. Entry Date: 20080530. Revision Date: 20150711. Publication Type: Journal Article; CEU; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antibodies, Monoclonal -- Therapeutic Use
KW - Leukemia, Lymphocytic, Chronic -- Drug Therapy
KW - Antibodies, Monoclonal -- Adverse Effects
KW - Chi Square Test
KW - Clinical Trials
KW - Confidence Intervals
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Female
KW - Kaplan-Meier Estimator
KW - Log-Rank Test
KW - Male
KW - Treatment Outcomes
KW - United States Food and Drug Administration
KW - Human
SP - 167
EP - 174
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 2
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On September 19, 2007, the U.S. Food and Drug Administration granted regular approval and expanded labeling for alemtuzumab (Campath((R)); Genzyme Corporation, Cambridge, MA) as single-agent treatment for B-cell chronic lymphocytic leukemia (B-CLL). Alemtuzumab was initially approved in 2001 under accelerated approval regulations. Conversion to regular approval was based on a single study submitted to verify clinical benefit. Efficacy and safety were demonstrated in an open-label, international, multicenter, randomized trial of 297 patients with previously untreated, Rai stage I-IV B-CLL experiencing progression of their disease. Patients were randomized to either alemtuzumab, 30 mg i.v. over 2 hours three times per week on alternate days for a maximum of 12 weeks, or chlorambucil, 40 mg/m(2) orally every 28 days for a maximum of 12 months. The progression-free survival time, the primary study endpoint, was significantly longer in the alemtuzumab arm than in the chlorambucil arm. Both the overall and complete response rates were also significantly higher in the alemtuzumab arm. No differences in survival were observed. There were no new safety signals identified in patients receiving alemtuzumab. The most serious, and sometimes fatal, toxicities of alemtuzumab are cytopenias, infusion reactions, and infections.
SN - 1083-7159
AD - P.A.-C., U.S. Food and Drug Administration, 10903 New Hampshire Avenue, WO#22 Room 2307, Mail Stop 2343, Silver Spring, Maryland 20993, USA. suzanne.demko@fda.hhs.gov.
U2 - PMID: 18305062.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yorita, Krista L.
AU - Holman, Robert C.
AU - Sejvar, James J.
AU - Steiner, Claudia A.
AU - Schonberger, Lawrence B.
T1 - Infectious Disease Hospitalizations Among Infants in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/02//
VL - 121
IS - 2
M3 - Article
SP - 244
EP - 252
SN - 00314005
AB - OBJECTIVE. This study describes the burden and epidemiologic features of infectious disease hospitalizations among infants in the United States. METHODS. Hospitalizations with an infectious disease listed as a primary diagnosis for infants (<1 year of age) in the United States during 2003 were examined by using the Kids' Inpatient Database. National estimates of infectious disease hospitalizations, hospitalization rates, and various hospital parameters were examined. RESULTS. During 2003, an estimated 286 739 infectious disease hospitalizations occurred among infants in the United States and accounted for 42.8% of all infant hospitalizations. The national infectious disease hospitalization rate was 7010.8 hospitalizations per I00 000 live births, or ~1 infectious disease hospitalization for every 14 infants. The median length of stay was 3 days, and stays totaled >1 million hospital days for infants. Infectious disease hospitalization rates were highest among boys and nonwhite infants. The most commonly listed diagnoses among the infant infectious disease hospitalizations included lower respiratory tract infections (59.0%), kidney, urinary tract, and bladder infections (7.6%), upper respiratory tract infections (6.5%), and septicemia (6.5%). The median cost of an infectious disease hospitalization was $2235, with total annual hospital costs of approximately $690 million, among infants in the United States. CONCLUSIONS. Infectious disease hospitalizations among infants account for substantial health care expenditures and hospital time in the United States, with respiratory disease hospitalizations constituting more than one half of all hospitalizations. Younger infants, boys, and nonwhite infants were at increased risk for infectious disease hospitalization. Measures to reduce racial disparities and the occurrence of respiratory tract infections should substantially decrease the infectious disease burden among infants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANTS -- Care
KW - INFANTS -- Health
KW - COMMUNICABLE diseases
KW - RESPIRATORY infections
KW - SEPTICEMIA
KW - UNITED States
KW - hospitalization
KW - infant
KW - infectious disease
N1 - Accession Number: 29966008; Yorita, Krista L. 1; Email Address: kyorita@cdc.gov Holman, Robert C. 1 Sejvar, James J. 1 Steiner, Claudia A. 2 Schonberger, Lawrence B. 1; Affiliation: 1: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 2: Healthcare Cost and Utilization Project, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Feb2008, Vol. 121 Issue 2, p244; Subject Term: INFANTS -- Care; Subject Term: INFANTS -- Health; Subject Term: COMMUNICABLE diseases; Subject Term: RESPIRATORY infections; Subject Term: SEPTICEMIA; Subject Term: UNITED States; Author-Supplied Keyword: hospitalization; Author-Supplied Keyword: infant; Author-Supplied Keyword: infectious disease; Number of Pages: 9p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1542/peds.2007-1392
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doney, Brent
AU - Greskevitch, Mark
AU - Groce, Dennis
AU - Syamlal, Girija
AU - Ki Moon Bang
T1 - Survey Exposes some Shortcomings in Respirator Programs.
JO - Pulp & Paper
JF - Pulp & Paper
Y1 - 2008/02//
VL - 82
IS - 2
M3 - Article
SP - 26
EP - 27
PB - RISI, Inc.
SN - 00334081
AB - The article highlights the results of a 2001 survey on respirator use and practices in the Paper and Allied Products manufacturing establishments in the U.S. The survey found that approximately 9.4% or an estimated 674 establishments in the industry used respirators for required purposes as compared with All Private Industry. The respiratory protection program quality indicators being used by the establishments include the availability of a written change-out schedule for air-purifying gas/vapor filters and the use of dust masks for other purposes.
KW - INDUSTRIAL surveys
KW - BREATHING apparatus
KW - PAPER industry
KW - PROTECTIVE clothing
KW - UNITED States
N1 - Accession Number: 29983211; Doney, Brent 1; Greskevitch, Mark 1; Groce, Dennis 2; Syamlal, Girija 1; Ki Moon Bang 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH), Division of Respiratory Disease Studies, Morgantown, WV; 2: EG&G Technical Services, Inc., Pittsburgh, PA; Issue Info: Feb2008, Vol. 82 Issue 2, p26; Thesaurus Term: INDUSTRIAL surveys; Thesaurus Term: BREATHING apparatus; Thesaurus Term: PAPER industry; Thesaurus Term: PROTECTIVE clothing; Subject: UNITED States; NAICS/Industry Codes: 424110 Printing and Writing Paper Merchant Wholesalers; NAICS/Industry Codes: 424130 Industrial and Personal Service Paper Merchant Wholesalers; NAICS/Industry Codes: 322121 Paper (except Newsprint) Mills; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Mayer, J.
AU - Cheeseman, M.A.
AU - Twaroski, M.L.
T1 - Structure–activity relationship analysis tools: Validation and applicability in predicting carcinogens
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2008/02//
VL - 50
IS - 1
M3 - Article
SP - 50
EP - 58
SN - 02732300
AB - Abstract: OncoLogic® and MultiCASE (MCASE) are two structure–activity relationship (SAR) analysis software programs available to screen compounds for potential carcinogenicity. Ashby–Tennant structural alerts [Ashby, J., Tennant, R.W., 1991. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257, 229–306] and genetic toxicity testing may also be used to assess/predict this endpoint. Six-hundred and fifty compounds tested for carcinogenicity whose results were tabulated in the Carcinogenic Potency Database (CPDB) were used to validate and compare the predictivity of OncoLogic® (Version 4.1), MCASE (Version 3.1), Ashby–Tennant structural alerts, and genetic toxicity testing, individually and in combination. The sensitivity of the methods for predicting carcinogens and the specificity for predicting non-carcinogens was examined. Potent carcinogens, defined as those with TD50 values of less than 6.25mg/kg bw/d, were then examined separately. It is concluded that SAR analysis programs and structural alerts perform well for compounds with low human exposure levels and have the potential to supplement the results of routinely requested genetic toxicity tests in a weight-of-evidence approach in predicting carcinogenicity, although each method of analysis has limitations regarding applicability. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogens
KW - Hazardous substances
KW - Toxicity testing
KW - Structure-activity relationships (Biochemistry)
KW - Ashby–Tennant structural alerts
KW - Carcinogenic potency database
KW - FDA
KW - Food contact notifications
KW - MCASE
KW - Mutagenicity
KW - OncoLogic
KW - QSAR
KW - SAR
KW - Structure–activity relationships
N1 - Accession Number: 28059924; Mayer, J.; Email Address: julie.mayer@fda.hhs.gov; Cheeseman, M.A. 1; Twaroski, M.L. 1; Affiliations: 1: Food and Drug Administration, Division of Food Contact Notifications, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Issue Info: Feb2008, Vol. 50 Issue 1, p50; Thesaurus Term: Carcinogens; Thesaurus Term: Hazardous substances; Thesaurus Term: Toxicity testing; Thesaurus Term: Structure-activity relationships (Biochemistry); Author-Supplied Keyword: Ashby–Tennant structural alerts; Author-Supplied Keyword: Carcinogenic potency database; Author-Supplied Keyword: FDA; Author-Supplied Keyword: Food contact notifications; Author-Supplied Keyword: MCASE; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: OncoLogic; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: SAR; Author-Supplied Keyword: Structure–activity relationships; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.yrtph.2007.09.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miller, T.J.
AU - Honchel, R.
AU - Espandiari, P.
AU - Knapton, A.
AU - Zhang, J.
AU - Sistare, F.D.
AU - Hanig, J.P.
T1 - The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2008/02//
VL - 50
IS - 1
M3 - Article
SP - 87
EP - 97
SN - 02732300
AB - Abstract: The use of transgenic rodents may overcome many limitations of traditional cancer studies. Regulatory perspectives continue to evolve as new models are developed and validated. The transgenic mouse, K6/ODC, develops epidermal tumors when exposed to genotoxic carcinogens. In this study, K6/ODC mice were evaluated for model fitness and health robustness in a 36-week study to determine oncogenic risk of residual DNA in vaccines from neoplastic cell substrates. K6/ODC and C57BL/6 mice were treated with T24-H-ras expression plasmid, carrier vector DNA, or saline topically or by subcutaneous injection. One group of K6/ODC mice received 7,12-dimethylbenz-[a]anthracene [DMBA] dermally. Only DMBA-treated mice developed papillomas by six weeks, increasing in incidence to 25 weeks. By week 11, many K6/ODC mice showed severe dehydration and dermal eczema. By week 32, (6/8) surviving K6/ODC mice showed loss of mobility and balance. Microscopic evaluation of tissues revealed dermal/sebaceous gland hyperplasia, follicular dystrophy, splenic atrophy, and amyloid deposition/neutrophilic infiltration within liver, heart, and spleen, in all K6/ODC mice. Pathology was not detected in C57BL/6 mice. Progressive adverse health, decreased survival, and failure to develop papillomas to the H-ras plasmid suggest that K6/ODC mice may be an inappropriate alternative model for detection of oncogenic DNA and pharmaceutical carcinogenicity testing. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transgenic animals
KW - Drugs
KW - Carcinogenicity testing
KW - Cancer research
KW - Alternative cancer bioassay
KW - Cancer
KW - Carcinogenesis
KW - Cell substrate DNA
KW - K6/ODC
KW - Ornithine decarboxylase (ODC)
KW - Short term cancer assay
KW - Transgenic models
N1 - Accession Number: 28059928; Miller, T.J.; Email Address: terry.miller@fda.hhs.gov; Honchel, R. 1; Espandiari, P. 1; Knapton, A. 1; Zhang, J. 1; Sistare, F.D.; Hanig, J.P. 1; Affiliations: 1: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, White Oak Life Sciences Building 64, Room 2066, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA; Issue Info: Feb2008, Vol. 50 Issue 1, p87; Thesaurus Term: Transgenic animals; Thesaurus Term: Drugs; Thesaurus Term: Carcinogenicity testing; Subject Term: Cancer research; Author-Supplied Keyword: Alternative cancer bioassay; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: Cell substrate DNA; Author-Supplied Keyword: K6/ODC; Author-Supplied Keyword: Ornithine decarboxylase (ODC); Author-Supplied Keyword: Short term cancer assay; Author-Supplied Keyword: Transgenic models; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.yrtph.2007.10.011
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Vigeh, Mohsen
AU - Yokoyama, Kazuhito
AU - Ramezanzadeh, Fateme
AU - Dahaghin, Mojgan
AU - Fakhriazad, Elham
AU - Seyedaghamiri, Zahrabigom
AU - Araki, Shunichi
T1 - Blood manganese concentrations and intrauterine growth restriction
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2008/02//
VL - 25
IS - 2
M3 - Article
SP - 219
EP - 223
SN - 08906238
AB - Abstract: To assess the relationship between blood concentrations of manganese (Mn) and intrauterine growth restriction (IUGR), Mn levels in the umbilical cord blood (UCB) and the mother whole blood (MWB) samples were measured in apparently healthy mothers and their newborns. Measurement was conducted by an inductively coupled plasma mass spectrometry. Manganese concentrations in MWB were significantly lower (p <0.01) in IUGR cases than in appropriate for gestational age (AGA) cases (mean±S.D.; 16.7±4.8 and 19.1±5.9μg/l, respectively). Conversely, UCB concentrations of Mn were significantly higher (p <0.05) in IUGR newborns than AGA newborns (44.7±19.1 and 38.2±13.1μg/l, respectively). Logistic regression analysis demonstrated significant relationships of the mother whole blood and the umbilical cord blood concentrations of Mn in IUGR cases (OR=0.868, 1.044, respectively). The study suggests that manganese concentrations in MWB and UCB might induce different effects on birth weight in healthy mothers. Because intrauterine growth restriction is a multi-factorial problem, further epidemiological and clinical studies on larger numbers of subjects are needed to confirm the findings in the present study. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD
KW - MANGANESE
KW - CORD blood
KW - NEWBORN infants
KW - Coupled plasma mass spectrometry
KW - IUGR
KW - Manganese
KW - Mother whole blood
KW - Pregnancy
KW - Pregnancy outcome
KW - Trace element
KW - Umbilical cord
N1 - Accession Number: 31248640; Vigeh, Mohsen 1; Email Address: vigeh@h.jniosh.go.jp Yokoyama, Kazuhito 2 Ramezanzadeh, Fateme 3 Dahaghin, Mojgan 3 Fakhriazad, Elham 4 Seyedaghamiri, Zahrabigom 5 Araki, Shunichi 1; Affiliation: 1: International Center for Research Promotion and Informatics, National Institute of Occupational Safety and Health, 21-6 Nagao 6chome, Tama-ku, Kawasaki 214-8585, Japan 2: Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Tsu-shi, Mie 514-8507, Japan 3: Vali-e-Asr Reproductive Health Research Center, Medical Sciences, The University of Tehran, Imam Complex Hospitals, Keshavarz Ave., Tehran, Iran 4: Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, Tokyo 113-8421, Japan 5: Deputy for Health, Medical Sciences, The University of Tehran, Ghods Street, Keshavarz Ave., Tehran, Iran; Source Info: Feb2008, Vol. 25 Issue 2, p219; Subject Term: BLOOD; Subject Term: MANGANESE; Subject Term: CORD blood; Subject Term: NEWBORN infants; Author-Supplied Keyword: Coupled plasma mass spectrometry; Author-Supplied Keyword: IUGR; Author-Supplied Keyword: Manganese; Author-Supplied Keyword: Mother whole blood; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: Pregnancy outcome; Author-Supplied Keyword: Trace element; Author-Supplied Keyword: Umbilical cord; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.reprotox.2007.11.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stout, N.A.
T1 - The public health approach to occupational injury research: From surveillance to prevention
JO - Safety Science
JF - Safety Science
Y1 - 2008/02//
VL - 46
IS - 2
M3 - Article
SP - 230
EP - 233
SN - 09257535
AB - Abstract: The National Institute for Occupational Safety and Health (NIOSH) in the US uses the public health model as the framework for occupational injury prevention research. This model is described, along with where we have made progress in this research process, and where we need to focus our efforts in the future. The specific role of surveillance in research and prevention of occupational injuries is also discussed, as well as the importance of partnership efforts to facilitate the transfer of research to practice. Suggestions are provided for stimulating a global approach to surveillance and to the transfer of research to practice. [Copyright &y& Elsevier]
AB - Copyright of Safety Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Work-related injuries
KW - Accidents
KW - Disasters
KW - Disability evaluation
KW - Occupational injury
N1 - Accession Number: 29381365; Stout, N.A. 1; Email Address: nas5@cdc.gov; Affiliations: 1: Division of Safety Research, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Feb2008, Vol. 46 Issue 2, p230; Subject Term: Work-related injuries; Subject Term: Accidents; Subject Term: Disasters; Subject Term: Disability evaluation; Author-Supplied Keyword: Occupational injury; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ssci.2007.04.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - De Vries, Henry J. C.
AU - Van Der Bij, Akke K.
AU - Fennema, Johan S. A.
AU - Smit, Colette
AU - Wolf, Frank De
AU - Prins, Maria
AU - Coutinho, Roel A.
AU - Morré, Servaas A.
T1 - Lymphogranuloma Venereum Proctitis in Men Who Have Sex With Men Is Associated With Anal Enema Use and High-Risk Behavior.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2008/02//
VL - 35
IS - 2
M3 - Article
SP - 203
EP - 208
SN - 01485717
AB - The article attempts to describe the results of a cross-sectional study started shortly after the recent outbreak of lymphogranuloma venereum proctitis (LGV) in 2004. In doing so, the authors investigate the relationships between potential risk factors and LGV among men who have sex with men (MSM). Results show that MSM with LGV proctitis, gonorrheal proctitis, and proctitis of unknown etiology exhibit high-risk behavior. Enema use seems to play a key role in the transmission of LGV proctitis. Other significant results are discussed.
KW - LYMPHOGRANULOMA venereum
KW - SEXUALLY transmitted diseases
KW - PATIENTS
KW - SEXUALLY transmitted diseases -- Risk factors
KW - CHLAMYDIA infections
KW - DISEASES -- Causes & theories of causation
KW - COMMUNICABLE diseases
KW - SEXUAL intercourse
KW - SAME-sex relationships
N1 - Accession Number: 28792925; De Vries, Henry J. C. 1,2; Email Address: h.j.devries@amc.nl Van Der Bij, Akke K. 3 Fennema, Johan S. A. 3 Smit, Colette 3,4 Wolf, Frank De 4 Prins, Maria 3,5 Coutinho, Roel A. 3,5,6 Morré, Servaas A. 7,8,9; Affiliation: 1: STI Outpatient Clinic, Cluster Infectious Diseases, Public Health Service Amsterdam 2: Department of HIV and STD Research, Cluster Infectious Diseases, Public Health Service Amsterdam 3: Department of Dermatology, University of Amsterdam, Amsterdam 4: Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam 5: HIV Monitoring Foundation, Amsterdam 6: Centers for Infectious Diseases Control, National Institute for Public Health and the Environment Bilthoven, VU University Medical Center, Amsterdam, The Netherlands 7: Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands 8: Section Infectious Diseases, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands 9: Department of Medical Microbiology, Academic Hospital Maastricht, Maastricht, The Netherlands; Source Info: Feb2008, Vol. 35 Issue 2, p203; Subject Term: LYMPHOGRANULOMA venereum; Subject Term: SEXUALLY transmitted diseases; Subject Term: PATIENTS; Subject Term: SEXUALLY transmitted diseases -- Risk factors; Subject Term: CHLAMYDIA infections; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: COMMUNICABLE diseases; Subject Term: SEXUAL intercourse; Subject Term: SAME-sex relationships; Number of Pages: 6p; Document Type: Article
L3 - 10.1097/QLQ.0b013e31815abb08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hill, S. C.
AU - Liang, L.
T1 - Smoking in the home and children's health.
JO - Tobacco Control
JF - Tobacco Control
Y1 - 2008/02//
VL - 17
IS - 1
M3 - Article
SP - 32
EP - 37
SN - 09644563
AB - Objectives: We estimate for young children the annual excess health service use, healthcare expenditures, and disability bed days for respiratory conditions associated with exposure to smoking in the home in the United States. Methods: Health service use, healthcare expenditures and disability bed days data come from the 1999 and 2001 Medical Expenditure Panel Survey (MEPS). Reported smoking in the home comes from the linked National Health Interview Survey, from which the MEPS sample is drawn. Multivariate statistical analysis controls for potential confounding factors. The sample is 2759 children aged 0-4. Results: Smoking in the home is associated with an increase in the probability of emergency department visits for respiratory conditions by five percentage points and the probability of inpatient use for these conditions by three percentage points. There is no relation between indoor smoking by adults and either ambulatory visits or prescription drug expenditures. Overall, indoor smoking is associated with $117 in additional healthcare expenditures for respiratory conditions for each exposed child aged 0-4. Indoor smoking is also associated with an eight percentage point increase in the probability of having a bed day because of respiratory illness for children aged 1-4. Conclusions: Despite the significant progress made in tobacco control, many children are still exposed to secondhand smoke in their home. Reducing exposure to smoking in the home would probably reduce healthcare expenditures for respiratory conditions and improve children's health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Tobacco Control is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PASSIVE smoking in children
KW - SMOKING
KW - CHILDREN -- Health
KW - HEALTH facilities -- Utilization
KW - MEDICAL care costs
KW - UNITED States
N1 - Accession Number: 31126247; Hill, S. C. 1 Liang, L. 1; Email Address: lliang@ahrq.gov; Affiliation: 1: Center for Financing, Cost and Access Trends, Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Feb2008, Vol. 17 Issue 1, p32; Subject Term: PASSIVE smoking in children; Subject Term: SMOKING; Subject Term: CHILDREN -- Health; Subject Term: HEALTH facilities -- Utilization; Subject Term: MEDICAL care costs; Subject Term: UNITED States; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1136/tc.2007.020990
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31126247&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105765964
T1 - Smoking in the home and children's health.
AU - Hill SC
AU - Liang L
Y1 - 2008/02//
N1 - Accession Number: 105765964. Language: English. Entry Date: 20080711. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. Instrumentation: National Health Interview Survey (NHIS). NLM UID: 9209612.
KW - Emergency Service -- Utilization
KW - Health Services Needs and Demand -- Utilization
KW - Passive Smoking -- Adverse Effects
KW - Asthma -- Economics
KW - Asthma -- Epidemiology
KW - Bronchitis -- Economics
KW - Bronchitis -- Epidemiology
KW - Child, Preschool
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Interview Guides
KW - Male
KW - Passive Smoking -- Economics
KW - Prevalence
KW - Risk Factors
KW - United States
KW - Human
SP - 32
EP - 37
JO - Tobacco Control
JF - Tobacco Control
JA - TOBACCO CONTROL
VL - 17
IS - 1
PB - BMJ Publishing Group
AB - OBJECTIVES: We estimate for young children the annual excess health service use, healthcare expenditures, and disability bed days for respiratory conditions associated with exposure to smoking in the home in the United States. METHODS: Health service use, healthcare expenditures and disability bed days data come from the 1999 and 2001 Medical Expenditure Panel Survey (MEPS). Reported smoking in the home comes from the linked National Health Interview Survey, from which the MEPS sample is drawn. Multivariate statistical analysis controls for potential confounding factors. The sample is 2759 children aged 0-4. RESULTS: Smoking in the home is associated with an increase in the probability of emergency department visits for respiratory conditions by five percentage points and the probability of inpatient use for these conditions by three percentage points. There is no relation between indoor smoking by adults and either ambulatory visits or prescription drug expenditures. Overall, indoor smoking is associated with $117 in additional healthcare expenditures for respiratory conditions for each exposed child aged 0-4. Indoor smoking is also associated with an eight percentage point increase in the probability of having a bed day because of respiratory illness for children aged 1-4. CONCLUSIONS: Despite the significant progress made in tobacco control, many children are still exposed to secondhand smoke in their home. Reducing exposure to smoking in the home would probably reduce healthcare expenditures for respiratory conditions and improve children's health.
SN - 0964-4563
AD - Center for Financing, Cost and Access Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA.
U2 - PMID: 18218804.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - JUN ZHANG
AU - KNAPTON, ALAN
AU - LIPSHULTZ, STEVEN E.
AU - WEAVER, JAMES L.
AU - HERMAN, EUGENE H.
T1 - Isoproterenol-induced Cardiotoxicity in Sprague-Dawley Rats: Correlation of Reversible and Irreversible Myocardial Injury with Release of Cardiac Troponin T and Roles of iNOS in Myocardial Injury.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/02//
VL - 36
IS - 2
M3 - Article
SP - 277
EP - 288
SN - 01926233
AB - The present study was undertaken to characterize myocardial lesions in the rat induced by loWdoses of isoproterenol (Iso) and to correlate lesion severity with release of cardiac troponin T (cTnT) and changes in myocyte iNOS expression. Two types of cardiac injury patterns were observed. A Type I response, noted 3 or 6 hours postdosing with 8, 16, 32, or 64 µg/kg Iso, included potential reversible myocardial alterations associated with slight increases in serum cTnT (< 0.3 ng/mL) and a slight reduction in myocyte cTnT immunoreactivity. The second type of response noted 3, 6, 12, 24 or 48 hours postdosing with 125, 250, or 500 µg/kg Iso consisted of irreversible myocyte alterations, together with significant increases in serum cTnT (3–14 ng/mL) and a marked reduction of cTnT immunoreactivity. By 48 hours the hearts of rats dosed with 125–500 µg/kg Iso had developed interstitial fibrosis, and serum cTnT had declined to near control levels (0.06–0.18 ng/mL). Increases in iNOS immunoreactivity correlated with the lesion severity. These findings suggest that loWdoses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Apoptosis
KW - Myocardium
KW - Sprague Dawley rats
KW - Necrosis
KW - Isoproterenol
KW - cardiac troponins
KW - iNOS
KW - myocardial apoptosis
KW - myocardial necrosis
N1 - Accession Number: 55002191; JUN ZHANG 1; Email Address: jun.zhang@fda.hhs.gov; KNAPTON, ALAN 1; LIPSHULTZ, STEVEN E. 2; WEAVER, JAMES L. 1; HERMAN, EUGENE H. 1; Affiliations: 1: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, USA; 2: Department of Pediatrics, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida, USA; Issue Info: 2008, Vol. 36 Issue 2, p277; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Apoptosis; Subject Term: Myocardium; Subject Term: Sprague Dawley rats; Subject Term: Necrosis; Subject Term: Isoproterenol; Author-Supplied Keyword: cardiac troponins; Author-Supplied Keyword: iNOS; Author-Supplied Keyword: myocardial apoptosis; Author-Supplied Keyword: myocardial necrosis; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 6391
L3 - 10.1177/0192623307313010
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HUBBS, ANN F.
AU - GOLDSMITH, WILLIAM T.
AU - KASHON, MICHAEL L.
AU - FRAZER, DAVID
AU - MERCER, ROBERT R.
AU - BATTELLI, LORI A.
AU - KULLMAN, GREGORY J.
AU - SCHWEGLER-BERRY, DIANE
AU - FRIEND, SHERRI
AU - CASTRANOVA, VINCENT
T1 - Respiratory Toxicologic Pathology of Inhaled Diacetyl in Sprague-Dawley Rats.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/02//
VL - 36
IS - 2
M3 - Article
SP - 330
EP - 344
SN - 01926233
AB - Inhalation of butter flavoring vapors by food manufacturing workers causes an emerging lung disease clinically resembling bronchiolitis obliterans. Diacetyl, an α-diketone, is a major component of these vapors. In rats, we investigated the toxicity of inhaled diacetyl at concentrations of up to 365 ppm (time weighted average), either as six-hour continuous exposures or as four brief, intense exposures over six hours. A separate group inhaled a single pulse of ∼1800 ppm diacetyl (92.9 ppm six-hour average). Rats were necropsied 18 to 20 hours after exposure. Diacetyl inhalation caused epithelial necrosis and suppurative to fibrinosuppurative inflammation in the nose, larynx, trachea, and bronchi. Bronchi were affected at diacetyl concentrations of 294.6 ppm or greater; the trachea and larynx were affected at diacetyl concentrations of 224 ppm or greater. Both pulsed and continuous exposure patterns caused epithelial injury. The nose had the greatest sensitivity to diacetyl. Ultrastructural changes in the tracheal epithelium included whorling and dilation of the rough endoplasmic reticulum, chromatin clumping beneath the nuclear membrane, vacuolation, increased intercellular space and foci of denuded basement membrane. Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food industry
KW - Diacetyl
KW - Sprague Dawley rats
KW - Flavor
KW - Respiratory obstructions
KW - 2
KW - 2,3-butanedione
KW - 3-butanedione
KW - airways obstruction
KW - bronchiolitis obliterans
KW - diacetyl
KW - flavorings
KW - food processing workers
KW - ketones
N1 - Accession Number: 55002186; HUBBS, ANN F. 1; Email Address: ahubbs@cdc.gov; GOLDSMITH, WILLIAM T. 1; KASHON, MICHAEL L. 1; FRAZER, DAVID 1; MERCER, ROBERT R. 1; BATTELLI, LORI A. 1; KULLMAN, GREGORY J. 2; SCHWEGLER-BERRY, DIANE 1; FRIEND, SHERRI 1; CASTRANOVA, VINCENT 1; Affiliations: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 2: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: 2008, Vol. 36 Issue 2, p330; Thesaurus Term: Food industry; Subject Term: Diacetyl; Subject Term: Sprague Dawley rats; Subject Term: Flavor; Subject Term: Respiratory obstructions; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2,3-butanedione; Author-Supplied Keyword: 3-butanedione; Author-Supplied Keyword: airways obstruction; Author-Supplied Keyword: bronchiolitis obliterans; Author-Supplied Keyword: diacetyl; Author-Supplied Keyword: flavorings; Author-Supplied Keyword: food processing workers; Author-Supplied Keyword: ketones; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 15p; Document Type: Article; Full Text Word Count: 9260
L3 - 10.1177/0192623307312694
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=55002186&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Benz, R. Daniel
AU - Contrera, Joseph F.
AU - Marchant, Carol A.
AU - Chihae Yang
T1 - Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/02//
VL - 18
IS - 2/3
M3 - Article
SP - 189
EP - 206
PB - Taylor & Francis Ltd
SN - 15376516
AB - This report describes a coordinated use of four quantitative structure-activity relationship (QSAR) programs and an expert knowledge base system to predict the occurrence and the mode of action of chemical carcinogenesis in rodents. QSAR models were based upon a weight-of-evidence paradigm of carcinogenic activity that was linked to chemical structures (n = 1,572). Identical training data sets were configured for four QSAR programs (MC4PC, MDL-QSAR, BioEpisteme, and Leadscope PDM), and QSAR models were constructed for the male rat, female rat, composite rat, male mouse, female mouse, composite mouse, and rodent composite endpoints. Model predictions were adjusted to favor high specificity (>80%). Performance was shown to be affected by the method used to score carcinogenicity study findings and the ratio of the number of active to inactive chemicals in the QSAR training data set. Results demonstrated that the four QSAR programs were complementary, each detecting different profiles of carcinogens. Accepting any positive prediction from two programs showed better overall performance than either of the single programs alone; specificity, sensitivity, and Chi-square values were 72.9%, 65.9%, and 223, respectively, compared to 84.5%, 45.8%, and 151. Accepting only consensus-positive predictions using any two programs had the best overall performance and higher confidence; specificity, sensitivity, and Chi-square values were 85.3%, 57.5%, and 287, respectively. Specific examples are provided to demonstrate that consensus-positive predictions of carcinogenicity by two QSAR programs identified both genotoxic and nongenotoxic carcinogens and that they detected 98.7% of the carcinogens linked in this study to Derek for Windows defined modes of action. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARCINOGENICITY
KW - CHEMICAL carcinogenesis
KW - TOXICOLOGY
KW - WINDOWS (Graphical user interfaces)
KW - QSAR (Biochemistry)
KW - STRUCTURE-activity relationships (Biochemistry)
KW - RODENTS as laboratory animals
KW - BioEpisteme
KW - Carcinogenicity
KW - Chemical Carcinogenesis
KW - Computational Toxicology
KW - Derek for Windows
KW - In Silico
KW - Leadscope
KW - MC4PC
KW - MDL-QSAR
KW - QSAR software
KW - Quantitative Structure-Activity Relationships
KW - SAR
N1 - Accession Number: 31314157; Matthews, Edwin J. 1; Email Address: Edwin.Mattews@fda.hhs.gov Kruhlak, Naomi L. 1 Benz, R. Daniel 1 Contrera, Joseph F. 1 Marchant, Carol A. 2 Chihae Yang 3; Affiliation: 1: Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA 2: Lhasa Limited, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, United Kingdom 3: Leadscope Inc., 1393 Dublin Road, Columbus, OH, 43215, USA; Source Info: Feb2008, Vol. 18 Issue 2/3, p189; Subject Term: CARCINOGENICITY; Subject Term: CHEMICAL carcinogenesis; Subject Term: TOXICOLOGY; Subject Term: WINDOWS (Graphical user interfaces); Subject Term: QSAR (Biochemistry); Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: RODENTS as laboratory animals; Author-Supplied Keyword: BioEpisteme; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Chemical Carcinogenesis; Author-Supplied Keyword: Computational Toxicology; Author-Supplied Keyword: Derek for Windows; Author-Supplied Keyword: In Silico; Author-Supplied Keyword: Leadscope; Author-Supplied Keyword: MC4PC; Author-Supplied Keyword: MDL-QSAR; Author-Supplied Keyword: QSAR software; Author-Supplied Keyword: Quantitative Structure-Activity Relationships; Author-Supplied Keyword: SAR; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 18p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/15376510701857379
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31314157&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Contrera, Joseph F.
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Benz, R. Daniel
T1 - In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/02//
VL - 18
IS - 2/3
M3 - Article
SP - 207
EP - 216
PB - Taylor & Francis Ltd
SN - 15376516
AB - Genetic toxicity testing is a critical parameter in the safety assessment of pharmaceuticals, food constituents, and environmental and industrial chemicals. Quantitative structure-activity relationship (QSAR) software offers a rapid, cost-effective means of prioritizing the genotoxic potential of chemicals. Our goal is to develop and validate a complete battery of complementary QSAR models for genetic toxicity. We previously reported the development of MDL-QSAR models for the prediction of mutations in Salmonella typhimurium and Escherichia coli (Contrera et al. 2005b); this report describes the development of eight additional models for mutagenicity, clastogenicity, and DNA damage. The models were created using MDL-QSAR atom-type E-state, simple connectivity and molecular property descriptor categories, and nonparametric discriminant analysis. In 10% leave-group-out internal validation studies, the specificity of the models ranged from 63% for the mouse lymphoma (L5178Y-tk) model to 88% for chromosome aberrations in vivo. Sensitivity ranged from a high of 74% for the mouse lymphoma model to a low of 39% for the unscheduled DNA synthesis model. The receiver operator characteristic (ROC) was ≥2.00, a value indicative of good predictive performance. The predictive performance of MDL-QSAR models was also shown to compare favorably to the results of MultiCase MC4PC (Matthews et al. 2006b) genotoxicity models prepared with the same training data sets. MDL-QSAR software models exhibit good specificity, sensitivity, and coverage and they can provide rapid and cost-effective large-scale screening of compounds for genotoxic potential by the chemical and pharmaceutical industry and for regulatory decision support applications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL drug trials
KW - TOXICITY testing
KW - QSAR (Biochemistry)
KW - COMPUTER software
KW - GENETIC toxicology
KW - SALMONELLA typhimurium
KW - ESCHERICHIA coli
KW - DNA damage
KW - DRUG development
KW - MUTAGENICITY testing
KW - Clastogenicity
KW - DNA Damage
KW - Drug Development
KW - E-State Indices
KW - Electrotopological
KW - Genetic Toxicity
KW - Genotoxic
KW - In Silico Screening
KW - MC4PC
KW - Mutagenicity
KW - Predictive Toxicology
KW - QSAR
N1 - Accession Number: 31314156; Contrera, Joseph F. 1; Email Address: jfcontrera@verizon.net Matthews, Edwin J. 1 Kruhlak, Naomi L. 1 Benz, R. Daniel 1; Affiliation: 1: Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA; Source Info: Feb2008, Vol. 18 Issue 2/3, p207; Subject Term: CLINICAL drug trials; Subject Term: TOXICITY testing; Subject Term: QSAR (Biochemistry); Subject Term: COMPUTER software; Subject Term: GENETIC toxicology; Subject Term: SALMONELLA typhimurium; Subject Term: ESCHERICHIA coli; Subject Term: DNA damage; Subject Term: DRUG development; Subject Term: MUTAGENICITY testing; Author-Supplied Keyword: Clastogenicity; Author-Supplied Keyword: DNA Damage; Author-Supplied Keyword: Drug Development; Author-Supplied Keyword: E-State Indices; Author-Supplied Keyword: Electrotopological; Author-Supplied Keyword: Genetic Toxicity; Author-Supplied Keyword: Genotoxic; Author-Supplied Keyword: In Silico Screening; Author-Supplied Keyword: MC4PC; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: Predictive Toxicology; Author-Supplied Keyword: QSAR; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/15376510701857106
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31314156&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kruhlak, Naomi L.
AU - Choi, Sydney S.
AU - Contrera, Joseph F.
AU - Weaver, James L.
AU - Willard, James M.
AU - Hastings, Kenneth L.
AU - Sancilio, Lawrence F.
T1 - Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/02//
VL - 18
IS - 2/3
M3 - Article
SP - 217
EP - 227
PB - Taylor & Francis Ltd
SN - 15376516
AB - Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development of pharmaceuticals. This report describes the construction of a database of PL findings in a variety of animal species and its use as a training data set for computational toxicology software. PL data and chemical structures were compiled from the published literature, existing pharmaceutical databases, and Food and Drug Administration (FDA) internal reports yielding a total of 583 compounds suitable for modeling. The database contained 190 (33%) positive drugs and 393 (77%) negative drugs, of which 39 were electron microscopy-confirmed negative compounds and 354 were classified as negatives due to the absence of positive reported data. Of the 190 positive findings, 76 were electron microscopy confirmed and 114 were considered positive based on other evidence. Quantitative structure-activity relationship (QSAR) models were constructed using two commercially available software programs, MC4PC and MDL-QSAR, and internal cross-validation (10 × 10%) experiments were performed to assess their predictive performance. Performance parameters for the MC4PC model were specificity 92%, sensitivity 50%, concordance 78%, positive predictivity 76%, and negative predictivity 78%. For MDL-QSAR, predictive performance was similar: specificity 80%, sensitivity 76%, concordance 79%, positive predictivity 65%, and negative predictivity 87%. By combining the output of the two QSAR programs, the overall predictive performance was vastly improved and sensitivity could be optimized to 81% without significant loss of specificity (79%). Many of the structural alerts and significant molecular descriptors obtained from the QSAR software were found to be associated with parts of active molecules known for their cationic amphiphilic drug (CAD) properties supporting the hypothesis that the endpoint of PL is statistically correlated with chemical structure. QSAR models can be useful tools for screening drug candidate molecules for potential PL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - PHOSPHOLIPIDS
KW - TOXICOLOGY
KW - QSAR (Biochemistry)
KW - LABORATORY animals
KW - DRUGS
KW - Computational Toxicology
KW - Consensus Predictions
KW - Cross-Validation
KW - Database
KW - In Silico Modeling
KW - MC4PC
KW - MDL-QSAR
KW - Phospholipidosis
KW - QSAR
N1 - Accession Number: 31314155; Kruhlak, Naomi L. 1; Email Address: Naomi.Kruhlak@fda.hhs.gov Choi, Sydney S. 1 Contrera, Joseph F. 1 Weaver, James L. 1 Willard, James M. 1 Hastings, Kenneth L. 1 Sancilio, Lawrence F. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science,10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002; Source Info: Feb2008, Vol. 18 Issue 2/3, p217; Subject Term: DATABASES; Subject Term: PHOSPHOLIPIDS; Subject Term: TOXICOLOGY; Subject Term: QSAR (Biochemistry); Subject Term: LABORATORY animals; Subject Term: DRUGS; Author-Supplied Keyword: Computational Toxicology; Author-Supplied Keyword: Consensus Predictions; Author-Supplied Keyword: Cross-Validation; Author-Supplied Keyword: Database; Author-Supplied Keyword: In Silico Modeling; Author-Supplied Keyword: MC4PC; Author-Supplied Keyword: MDL-QSAR; Author-Supplied Keyword: Phospholipidosis; Author-Supplied Keyword: QSAR; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 11p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15376510701857262
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31314155&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arvidson, Kirk B.
AU - Valerio, Luis G.
AU - Diaz, Marilyn
AU - Chanderbhan, Ronald F.
T1 - In Silico Toxicological Screening of Natural Products.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/02//
VL - 18
IS - 2/3
M3 - Article
SP - 229
EP - 242
PB - Taylor & Francis Ltd
SN - 15376516
AB - This study closely examines six well-known naturally occurring dietary chemicals (estragole, pulegone, aristolochic acid I, lipoic acid, 1-octacosanol, and epicatechin) with known human exposure, chemical metabolism, and mechanism of action (MOA) using in silico screening methods. The goal of this study was to take into consideration the available information on these chemicals in terms of MOA and experimentally determined toxicological data, and compare them to the in silico predictive modeling results produced from a series of computational toxicology software. After these analyses, a consensus modeling prediction was formulated in light of the weight of evidence for each natural product. We believe this approach of examining the experimentally determined mechanistic data for a given chemical and comparing it to in silico generated predictions and data mining is a valid means to evaluating the utility of the computational software, either alone or in combination with each other. We find that consensus predictions appear to be more accurate than the use of only one or two software programs and our in silico results are in very good agreement with the experimental toxicity data for the natural products screened in this study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGICAL chemistry
KW - NATURAL products
KW - MENTHENONE
KW - LIPOIC acid
KW - DATA analysis
KW - COMPUTER software
KW - DATA mining
KW - INFORMATION resources management
KW - METABOLISM
KW - Botanicals
KW - Cancer
KW - Carcinogenicity
KW - Computational Toxicology
KW - Dietary Chemicals
KW - In Silico
KW - Mechanisms
KW - Natural Products
KW - QSAR
KW - Rodents
KW - SAR
KW - Structure-Activity Relationship
KW - Toxicity Prediction
N1 - Accession Number: 31314154; Arvidson, Kirk B. 1 Valerio, Luis G. 2; Email Address: luis.valerio@fda.hhs.gov Diaz, Marilyn 3 Chanderbhan, Ronald F. 2; Affiliation: 1: Division of Food Contact Notifications, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-275, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 2: Division of Biotechnology and GRAS Notice Review, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-255, 5100 Paint Branch Parkway, College Park, MD, 20740, USA 3: Department of Chemical Engineering, University of Puerto Rico, Carr. 108, Bo. Miradero, Mayagüez, Puerto, Rico 00680; Source Info: Feb2008, Vol. 18 Issue 2/3, p229; Subject Term: TOXICOLOGICAL chemistry; Subject Term: NATURAL products; Subject Term: MENTHENONE; Subject Term: LIPOIC acid; Subject Term: DATA analysis; Subject Term: COMPUTER software; Subject Term: DATA mining; Subject Term: INFORMATION resources management; Subject Term: METABOLISM; Author-Supplied Keyword: Botanicals; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Computational Toxicology; Author-Supplied Keyword: Dietary Chemicals; Author-Supplied Keyword: In Silico; Author-Supplied Keyword: Mechanisms; Author-Supplied Keyword: Natural Products; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Rodents; Author-Supplied Keyword: SAR; Author-Supplied Keyword: Structure-Activity Relationship; Author-Supplied Keyword: Toxicity Prediction; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 519190 All Other Information Services; Number of Pages: 14p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1080/15376510701856991
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31314154&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, C.
AU - Hasselgren, C. H.
AU - Boyer, S.
AU - Arvidson, K.
AU - Aveston, S.
AU - Dierkes, P.
AU - Benigni, R.
AU - Benz, R. D.
AU - Contrera, J.
AU - Kruhlak, N. L.
AU - Matthews, E. J.
AU - Han, X.
AU - Jaworska, J.
AU - Kemper, R. A.
AU - Rathman, J. F.
AU - Richard, A. M.
T1 - Understanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/02//
VL - 18
IS - 2/3
M3 - Article
SP - 277
EP - 295
PB - Taylor & Francis Ltd
SN - 15376516
AB - Genetic toxicity data from various sources were integrated into a rigorously designed database using the ToxML schema. The public database sources include the U.S. Food and Drug Administration (FDA) submission data from approved new drug applications, food contact notifications, generally recognized as safe food ingredients, and chemicals from the NTP and CCRIS databases. The data from public sources were then combined with data from private industry according to ToxML criteria. The resulting "integrated" database, enriched in pharmaceuticals, was used for data mining analysis. Structural features describing the database were used to differentiate the chemical spaces of drugs/candidates, food ingredients, and industrial chemicals. In general, structures for drugs/candidates and food ingredients are associated with lower frequencies of mutagenicity and clastogenicity, whereas industrial chemicals as a group contain a much higher proportion of positives. Structural features were selected to analyze endpoint outcomes of the genetic toxicity studies. Although most of the well-known genotoxic carcinogenic alerts were identified, some discrepancies from the classic Ashby-Tennant alerts were observed. Using these influential features as the independent variables, the results of four types of genotoxicity studies were correlated. High Pearson correlations were found between the results of Salmonella mutagenicity and mouse lymphoma assay testing as well as those from in vitro chromosome aberration studies. This paper demonstrates the usefulness of representing a chemical by its structural features and the use of these features to profile a battery of tests rather than relying on a single toxicity test of a given chemical. This paper presents data mining/profiling methods applied in a weight-of-evidence approach to assess potential for genetic toxicity, and to guide the development of intelligent testing strategies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC toxicology
KW - DATABASES
KW - COMPUTER interfaces
KW - STRUCTURE-activity relationships (Biochemistry)
KW - QSAR (Biochemistry)
KW - DATA mining
KW - CHEMICALS
KW - UNITED States
KW - Databases
KW - Genetic Toxicity
KW - QSAR
KW - SAR
KW - Structural Alerts
KW - ToxML
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31314149; Yang, C. 1; Email Address: cyang@leadscope.com Hasselgren, C. H. 2 Boyer, S. 2 Arvidson, K. 3 Aveston, S. 4 Dierkes, P. 4 Benigni, R. 5 Benz, R. D. 6 Contrera, J. 6 Kruhlak, N. L. 6 Matthews, E. J. 6 Han, X. 7 Jaworska, J. 8 Kemper, R. A. 9 Rathman, J. F. 10 Richard, A. M. 11; Affiliation: 1: Leadscope, Inc., 1393 Dublin Road, Columbus, OH, 43215 2: Computational Toxicology, Safety Assessment, AstraZeneca R&D, 431 83 Molndal, Sweden 3: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, 5100 Paint Branch Parkway, College Park, MD, 20740 4: Unilever, Safety and Environmental Assurance Centre, Colworth House, Sharnbrook, Bedford, Bedfordshire, MK44 1LQ, England 5: Istituto Superiore di Sanita', Environment and Health Department, Viale Regina Elena 299, 00161, Rome, Italy 6: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002 7: DuPont Haskell Global Centers for Health & Environmental Sciences, Newark, DE 19714 8: Procter & Gamble, Central Product Safety, 100 Temselaan, 1853 Strombeek-Bever, Belgium 9: Boehringer Ingelheim Pharmaceuticals Inc., 175 Briar Ridge Rd, Ridgefield, CT, 06877-0368 10: Department of Chemical and Biomolecular Engineering, The Ohio State University, 140 W, 19th Ave., Columbus, OH 43210 11: National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711; Source Info: Feb2008, Vol. 18 Issue 2/3, p277; Subject Term: GENETIC toxicology; Subject Term: DATABASES; Subject Term: COMPUTER interfaces; Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: QSAR (Biochemistry); Subject Term: DATA mining; Subject Term: CHEMICALS; Subject Term: UNITED States; Author-Supplied Keyword: Databases; Author-Supplied Keyword: Genetic Toxicity; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: SAR; Author-Supplied Keyword: Structural Alerts; Author-Supplied Keyword: ToxML; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 19p; Illustrations: 2 Diagrams, 9 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/15376510701857502
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31314149&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dimitrakov, Jordan
AU - Joffe, Hylton V.
AU - Soldin, Steven J.
AU - Bolus, Roger
AU - Buffington, C.A. Tony
AU - Nickel, J. Curtis
T1 - Adrenocortical Hormone Abnormalities in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
JO - Urology
JF - Urology
Y1 - 2008/02//
VL - 71
IS - 2
M3 - Article
SP - 261
EP - 266
SN - 00904295
AB - Objectives: To identify adrenocortical hormone abnormalities as indicators of endocrine dysfunction in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods: We simultaneously measured the serum concentrations of 12 steroids in patients with CP/CPPS and controls, using isotope dilution liquid chromatography, followed by atmospheric pressure photospray ionization and tandem mass spectrometry. Results: We evaluated 27 patients with CP/CPPS and 29 age-matched asymptomatic healthy controls. In the mineralocorticoid pathway, progesterone was significantly greater, and the corticosterone and aldosterone concentrations were significantly lower, in the patients with CP/CPPS than in the controls. In the glucocorticoid pathway, 11-deoxycortisol was significantly lower and the cortisol concentrations were not different between the patients and controls. In the sex steroid pathway, the androstenedione and testosterone concentrations were significantly greater in those with CP/CPPS than in the controls. The estradiol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate concentrations were not different between the patients and controls. The National Institutes of Health-Chronic Prostatitis Symptom Index total and pain domain scores correlated positively with the 17-hydroxyprogesterone and aldosterone (P <0.001) and negatively with the cortisol (P <0.001) concentrations. Conclusions: Our results suggest reduced activity of CYP21A2 (P450c21), the enzyme that converts progesterone to corticosterone and 17-hydroxyprogesterone to 11-deoxycortisol. Furthermore, these results provide insights into the biologic basis of CP/CPPS. Follow-up studies should explore the possibility that patients with CP/CPPS meet the diagnostic criteria for nonclassic congenital adrenal hyperplasia and whether the hormonal findings improve or worsen in parallel with symptom severity. [Copyright &y& Elsevier]
AB - Copyright of Urology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADRENOCORTICAL hormones
KW - PROSTATE diseases
KW - PROSTATITIS
KW - PELVIC pain
N1 - Accession Number: 31117913; Dimitrakov, Jordan 1,2; Email Address: Jordan.Dimitrakov@childrens.harvard.edu Joffe, Hylton V. 3,4 Soldin, Steven J. 5,6,7,8,9 Bolus, Roger 10 Buffington, C.A. Tony 10,11 Nickel, J. Curtis 12; Affiliation: 1: Harvard Urological Diseases Research Center, Children’s Hospital Boston, Boston, Massachusetts 2: Harvard Medical School, Boston, Massachusetts 3: U.S. Food and Drug Administration, Silver Spring, Maryland 4: Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 5: Department of Medicine, George Washington University School of Medicine, Washington, DC 6: Department of Pharmacology, George Washington University School of Medicine, Washington, DC 7: Bioanalytical Core Laboratory, Georgetown Clinical Research Center, Washington, DC 8: Department of Pathology, George Washington University School of Medicine, Washington, DC 9: Department of Pediatrics, George Washington University School of Medicine, Washington, DC 10: University of California, Los Angeles, Center for Neurovisceral Sciences and Women’s Health, Los Angeles, California 11: Department of Clinical Veterinary Sciences, Ohio State University, Columbus, Ohio 12: Department of Urology, Queen’s University, Kingston, Ontario, Canada; Source Info: Feb2008, Vol. 71 Issue 2, p261; Subject Term: ADRENOCORTICAL hormones; Subject Term: PROSTATE diseases; Subject Term: PROSTATITIS; Subject Term: PELVIC pain; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.urology.2007.09.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31117913&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-01200-003
AN - 2008-01200-003
AU - van Laere, Igor
AU - Withers, James
T1 - Integrated care for homeless people--sharing knowledge and experience in practice, education and research: Results of the networking efforts to find homeless health workers.
JF - European Journal of Public Health
JO - European Journal of Public Health
JA - Eur J Public Health
Y1 - 2008/02//
VL - 18
IS - 1
SP - 5
EP - 6
CY - United Kingdom
PB - Oxford University Press
SN - 1101-1262
SN - 1464-360X
AD - van Laere, Igor, GGD Municipal Public Health Service, Dr.Valckenier Outreach Practice for Homeless People, Postbus 2200, 1000 CE, Amsterdam, Netherlands
N1 - Accession Number: 2008-01200-003. PMID: 18211914 Partial author list: First Author & Affiliation: van Laere, Igor; GGD Municipal Public Health Service, Dr.Valckenier Outreach Practice for Homeless People, Amsterdam, Netherlands. Release Date: 20080825. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Homeless; Integrated Services; Social Workers. Minor Descriptor: Health; Knowledge Transfer; Physicians. Classification: Community & Social Services (3373). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Feb, 2008.
AB - Over the last dozen years, as doctors for homeless people in Pittsburgh, USA and Amsterdam, the Netherlands, we have been networking internationally and travelled the streets to find social and medical workers who bring care to homeless people. We felt the need to reach out on the streets to meet homeless people and their problems, and to reach into mainstream services, academic centres and research institutes, to meet the needs of professionals in housing, social and medical work to deliver integrated care. To provide care for prevention of homelessness and interventions to improve health of homeless people, the integrated knowledge and experience of a network is needed. As homeless health workers, we actively have to reach out for people in highest need and we have to reach into mainstream services to make many friends in practice, education and research to better deliver integrated care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - integrated care
KW - homeless people
KW - knowledge sharing
KW - practice
KW - education
KW - research
KW - social workers
KW - 2008
KW - Health Care Services
KW - Homeless
KW - Integrated Services
KW - Social Workers
KW - Health
KW - Knowledge Transfer
KW - Physicians
KW - 2008
DO - 10.1093/eurpub/ckm107
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01200-003&site=ehost-live&scope=site
UR - ivlaere@ggd.amsterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-02387-003
AN - 2008-02387-003
AU - Hsiao, Hongwei
AU - Hause, Mathew
AU - Powers, John R. Jr.
AU - Kau, Tsui-Ying
AU - Hendricks, Scott
AU - Simeonov, Peter I.
T1 - Effect of scaffold end frame carrying strategies on worker stepping response, postural stability, and perceived task difficulty.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 2008/02//
VL - 50
IS - 1
SP - 27
EP - 36
CY - US
PB - Human Factors & Ergonomics Society
SN - 0018-7208
SN - 1547-8181
AD - Hsiao, Hongwei, Protective Technology Branch, NIOSH, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2008-02387-003. PMID: 18354969 Partial author list: First Author & Affiliation: Hsiao, Hongwei; Protective Technology Branch, Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, US. Other Publishers: Sage Publications. Release Date: 20080512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Job Performance; Occupational Safety; Risk Factors; Task Complexity. Minor Descriptor: Nonprofessional Personnel; Posture; Walking. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Feb, 2008.
AB - Objective: This study determined the most favorable strategy for carrying scaffold end frames while minimizing the risk of injuries from being struck by an object, falling, and overexertion. Background: Scaffold erectors are at risk of high exposure to the aforementioned hazards associated with the dynamic human-scaffolding interface and work environments. Identifying an optimal work strategy can help reduce risk of injuries to the worker. Method: Three carrying methods, four types of work surfaces, two weights of scaffold frames, and three directions of stepping movement were tested in a laboratory with 18 construction workers. Results: The effects of carrying method on postural instability and task difficulty rating were significant for handling the 22-kg end frame. Response time, postural instability, and perceived task difficulty rating were significantly reduced when the 9-kg end frame was used as compared with the 22-kg frame. Conclusion: The symmetric side-carrying method was the best option for handling 22-kg scaffold end frames. A 9-kg end frame (e.g., made of reinforced lightweight materials) has the potential to reduce injury risk among scaffold handlers during their scaffold erection and dismantling jobs. Application: Scaffold erectors may want to adopt the symmetric side-carrying method as the primary technique for handling the 22-kg scaffold end frame, which is currently the one most used in the industry. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - scaffold handling
KW - end frame carrying
KW - injury risk
KW - worker performance
KW - posture
KW - task difficulty
KW - response time
KW - 2008
KW - Injuries
KW - Job Performance
KW - Occupational Safety
KW - Risk Factors
KW - Task Complexity
KW - Nonprofessional Personnel
KW - Posture
KW - Walking
KW - 2008
DO - 10.1518/001872008X250548
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-02387-003&site=ehost-live&scope=site
UR - hhsiao@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-02026-008
AN - 2008-02026-008
AU - Leggat, Peter A.
AU - Smith, Derek R.
AU - Clark, Michele J.
T1 - Prevalence and correlates of low back pain among occupational therapy students in Northern Queensland.
JF - Canadian Journal of Occupational Therapy / Revue Canadienne D'Ergothérapie
JO - Canadian Journal of Occupational Therapy / Revue Canadienne D'Ergothérapie
JA - Can J Occup Ther
Y1 - 2008/02//
VL - 75
IS - 1
SP - 35
EP - 41
CY - Canada
PB - Canadian Assn of Occupational Therapists
SN - 0008-4174
AD - Leggat, Peter A., School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, QLD, Australia, 4811
N1 - Accession Number: 2008-02026-008. PMID: 18323366 Other Journal Title: Canadian Journal of Occupational and Physiotherapy; Canadian Journal of Occupational Therapy. Partial author list: First Author & Affiliation: Leggat, Peter A.; School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, QLD, Australia. Other Publishers: Sage Publications. Release Date: 20080825. Correction Date: 20130318. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Back Pain; Epidemiology; Occupational Therapists; Risk Factors. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Professional Education & Training (3410). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 2008.
AB - Background: Although low back pain (LBP) is an important issue for the health profession, few studies have examined LBP among occupational therapy students. Purpose: To investigate the prevalence and distribution of LBP, its adverse sequelae; and to identify potential risk factors. Methods: In 2005, a self-reported questionnaire was administered to occupational therapy students in Northern Queensland. Findings: The 12-month period-prevalence of LBP was 64.6%. Nearly half (46.9%) had experienced pain for over 2 days, 38.8% suffered LBP that affected their daily lives, and 24.5% had sought medical treatment. The prevalence of LBP ranged from 45.5 to 77.1% (p = 0.004), while the prevalence of LBP symptoms persisting longer than two days was 34.1 to 62.5% (p = 0.020). Logistic regression analysis indicated that year of study and weekly computer usage were statistically-significant LBP risk factors. Implications: The occupational therapy profession will need to further investigate the high prevalence of student LBP identified in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence
KW - low back pain
KW - occupational therapy students
KW - risk factors
KW - 2008
KW - Back Pain
KW - Epidemiology
KW - Occupational Therapists
KW - Risk Factors
KW - 2008
DO - 10.2182/cjot.07.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-02026-008&site=ehost-live&scope=site
UR - Peter.Leggat@jcu.edu.au
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00131-003
AN - 2008-00131-003
AU - Gualdi-Russo, E.
AU - Albertini, A.
AU - Argnani, L.
AU - Celenza, F.
AU - Nicolucci, M.
AU - Toselli, S.
T1 - Weight status and body image perception in Italian children.
JF - Journal of Human Nutrition and Dietetics
JO - Journal of Human Nutrition and Dietetics
JA - J Hum Nutr Diet
Y1 - 2008/02//
VL - 21
IS - 1
SP - 39
EP - 45
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0952-3871
SN - 1365-277X
AD - Gualdi-Russo, E., Department of Biology and Evolution, University of Ferrara, Corso Ercole I d'Este n.32, 44100, Ferrara, Italy
N1 - Accession Number: 2008-00131-003. PMID: 18184393 Partial author list: First Author & Affiliation: Gualdi-Russo, E.; Department of Biology and Evolution, University of Ferrara, Ferrara, Italy. Other Publishers: Blackwell Publishing. Release Date: 20080317. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Body Image; Body Weight; Obesity. Minor Descriptor: Body Image Disturbances; Overweight; Satisfaction. Classification: Eating Disorders (3260); Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: Italy. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 2008.
AB - Background: Previous research suggests there is a tendency in overweight subjects to underestimate their weight status. This study investigated the perception of body image in Italian children, with particular regard to overweight children. Methods: Primary school children (n = 866) were recruited for this cross-sectional nutritional survey in northern Italy. Anthropometric measurements were performed to determine body mass index (BMI). Body image perception was assessed with the Body Silhouette Chart for preadolescent children shown to the children and to their mothers (n = 778) during an interview. A new scheme to identify wrong (F.1, F.2) or inappropriate (F.3) self figure responses in overweight subjects was used. Results: More than one-third of the Italian children examined were above the normal BMI range (prevalence of overweight: 35.8%, girls; 37.2%, boys). A higher degree of dissatisfaction was expressed by girls than by boys, and the percentage increased in overweight/obese children. A discrepancy between the self figure perception and the real nutritional status of the subject occurred in 6-9% of the overweight/obese children. Conclusion: The comparison of body image perception and anthropometric assessment of nutritional status could play an important role in future programs of nutritional surveillance as they provide indications of dissatisfaction and body image disturbances. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - weight status
KW - body image perception
KW - overweight children
KW - obesity
KW - body satisfaction
KW - 2008
KW - Body Image
KW - Body Weight
KW - Obesity
KW - Body Image Disturbances
KW - Overweight
KW - Satisfaction
KW - 2008
U1 - Sponsor: Italian Ministry of Health, Italy. Recipients: No recipient indicated
U1 - Sponsor: University of Ferrara, Italy. Recipients: No recipient indicated
U1 - Sponsor: University of Bologna, Italy. Recipients: No recipient indicated
DO - 10.1111/j.1365-277X.2007.00843.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00131-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-7274-547X
UR - gldmnl@unife.it
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00900-005
AN - 2008-00900-005
AU - Hussey, Peter
AU - Anderson, Gerard
AU - Berthelot, Jean-Marie
AU - Feek, Colin
AU - Kelley, Edward
AU - Osborn, Robin
AU - Raleigh, Veena
AU - Epstein, Arnold
T1 - Trends in socioeconomic disparities in health care quality in four countries.
JF - International Journal for Quality in Health Care
JO - International Journal for Quality in Health Care
JA - Int J Qual Health Care
Y1 - 2008/02//
VL - 20
IS - 1
SP - 53
EP - 61
CY - United Kingdom
PB - Oxford University Press
SN - 1353-4505
SN - 1464-3677
AD - Hussey, Peter, RAND, 1200 S. Hayes St, Arlington, VA, US
N1 - Accession Number: 2008-00900-005. PMID: 18024997 Partial author list: First Author & Affiliation: Hussey, Peter; RAND Corporation, Health Unit, Arlington, VA, US. Release Date: 20080421. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Countries; Health; Health Care Services; Quality of Care; Socioeconomic Status. Minor Descriptor: Trends. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Canada; New Zealand; England; US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2008.
AB - Objective: To provide a targeted portrait of socioeconomic disparities in health care quality in four countries and how those disparities have changed over time. Design: Within each country, comparisons between the highest and lowest quintiles of socioeconomic status were made to determine if disparities exist and if any observed disparities have been decreasing over a 5-year period. Setting: Small geographic areas in Canada, England, New Zealand and the United States. Data sources: Data were obtained by working with national health statistics agencies in each country. Results: There were socioeconomic disparities in health care quality and health status for most of the indicators studied in all four countries. The analysis included nine quality indicators in four countries, for a total of thirty-six observations. Twenty-six observations had a ratio of highest to lowest socioeconomic quintile of <0.95 or >1.05. These disparities generally persisted over time. The relative difference between the highest and lowest quintile decreased over time in eight of the twenty-one observations with time-series data available. Conclusion: The fact that disparities in a variety of indicators exist in four very different health systems underscores the importance of factors common to the four systems or factors outside the health system. Some successful strategies for reducing disparities could potentially be learned from the few examples of success in these countries. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trends
KW - socioeconomic disparities
KW - health care quality
KW - four countries
KW - 2008
KW - Countries
KW - Health
KW - Health Care Services
KW - Quality of Care
KW - Socioeconomic Status
KW - Trends
KW - 2008
U1 - Sponsor: Commonwealth Fund. Recipients: No recipient indicated
DO - 10.1093/intqhc/mzm055
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00900-005&site=ehost-live&scope=site
UR - peter_hussey@rand.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01847-010
AN - 2008-01847-010
AU - McGuinness, Kevin M.
AU - Coady, Jeff A.
AU - Perez, Jon T.
AU - Williams, N. Chanell
AU - McIntyre, David J.
AU - Schreiber, Merritt D.
T1 - Public mental health: The role of population-based and macrosystems interventions in the wake of Hurricane Katrina.
T3 - Psychologists Responding to Hurricane Katrina
JF - Professional Psychology: Research and Practice
JO - Professional Psychology: Research and Practice
JA - Prof Psychol Res Pr
Y1 - 2008/02//
VL - 39
IS - 1
SP - 58
EP - 65
CY - US
PB - American Psychological Association
SN - 0735-7028
SN - 1939-1323
AD - McGuinness, Kevin M., National Health Service Corps Field Site, 1600 Thorpe Road, Las Cruces, NM, US, 88012
N1 - Accession Number: 2008-01847-010. Other Journal Title: Professional Psychology. Partial author list: First Author & Affiliation: McGuinness, Kevin M.; Health Resources and Services Administration, Bureau of Health Professions, Rockville, MD, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Intervention; Mental Health Services; Natural Disasters; Public Health Services. Classification: Health & Mental Health Services (3370); Environmental Issues & Attitudes (4070). Population: Human (10). Location: US. References Available: Y. Page Count: 8. Issue Publication Date: Feb, 2008. Publication History: Accepted Date: Mar 19, 2007; Revised Date: Mar 14, 2007; First Submitted Date: Sep 11, 2006. Copyright Statement: American Psychological Association. 2008.
AB - Policy makers and decision makers are struggling to recognize the needs of shattered communities in the wake of unimaginable devastation. Professional psychology is providing some of the answers as it examines the consequences of disaster. The authors, 6 U.S. Public Health Service commissioned officers, describe their experiences in this new arena. Working at the federal, state, and local levels of government during the national response to the Hurricane Katrina disaster, the authors strive to identify high-value practice areas and define new roles for professional psychologists. The authors suggest that traditional crisis and trauma interventions are expanding to include nontraditional population-based and macrosystems-level interventions. Such roles are explored in narrative form, providing professional and personal insight into the impact that psychologists can have on decision makers who recognize their value and position them effectively. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - population-based
KW - macrosystems
KW - Katrina
KW - USNS Mercy
KW - systemic
KW - public mental health
KW - interventions
KW - 2008
KW - Intervention
KW - Mental Health Services
KW - Natural Disasters
KW - Public Health Services
KW - 2008
DO - 10.1037/0735-7028.39.1.58
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01847-010&site=ehost-live&scope=site
UR - kmcguinness@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00799-005
AN - 2008-00799-005
AU - Eggerth, Donald E.
T1 - From theory of work adjustment to person-environment correspondence counseling: Vocational psychology as positive psychology.
JF - Journal of Career Assessment
JO - Journal of Career Assessment
JA - J Career Assess
Y1 - 2008/02//
VL - 16
IS - 1
SP - 60
EP - 74
CY - US
PB - Sage Publications
SN - 1069-0727
SN - 1552-4590
N1 - Accession Number: 2008-00799-005. Partial author list: First Author & Affiliation: Eggerth, Donald E.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, US. Release Date: 20080128. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Industrial and Organizational Psychology; Occupational Adjustment; Occupational Guidance; Positive Psychology; Well Being. Classification: Occupational Interests & Guidance (3610). Population: Human (10). References Available: Y. Page Count: 15. Issue Publication Date: Feb, 2008.
AB - This article argues that vocational psychology is, and has been, positive psychology. It provides an overview of the theory of work adjustment (TWA), one of the most robust and best validated theories in vocational psychology. It also provides an introduction to person-environment-correspondence (PEC) counseling, an extension of the TWA concepts and dynamics into the realm of general counseling. Linkages are made between the extensive TWA literature and current conceptualizations regarding well-being. In particular, TWA is related to the work of Moos, Ryan and Deci, and Walsh. Although PEC has yet to generate the research base of TWA, it is argued that, given the similarities between TWA and PEC, one might reasonably expect that many of the connections between TWA and well-being would also generalize to PEC. In addition, it is argued that PEC offers a counseling model that is in keeping with the broader philosophical orientation of positive psychology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work adjustment
KW - well-being
KW - person-environment fit
KW - vocational psychology
KW - positive psychology
KW - person-environment-correspondence counseling
KW - 2008
KW - Industrial and Organizational Psychology
KW - Occupational Adjustment
KW - Occupational Guidance
KW - Positive Psychology
KW - Well Being
KW - 2008
DO - 10.1177/1069072707305771
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00799-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01847-011
AN - 2008-01847-011
AU - Mitchell, Monica J.
AU - Witman, Marjorie
AU - Taffaro, Craig
T1 - Reestablishing mental health services in St. Bernard Parish, Louisiana, following Hurricane Katrina.
T3 - Psychologists Responding to Hurricane Katrina
JF - Professional Psychology: Research and Practice
JO - Professional Psychology: Research and Practice
JA - Prof Psychol Res Pr
Y1 - 2008/02//
VL - 39
IS - 1
SP - 66
EP - 76
CY - US
PB - American Psychological Association
SN - 0735-7028
SN - 1939-1323
AD - Mitchell, Monica J., Cincinnati Children's Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, 3333 Burnet Avenue, MLC #3015, Cincinnati, OH, US, 45229-3039
N1 - Accession Number: 2008-01847-011. Other Journal Title: Professional Psychology. Partial author list: First Author & Affiliation: Mitchell, Monica J.; Cincinnati Children's Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, Cincinnati, OH, US. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Convention of the American Psychological Association, 114th, Aug, 2006, New Orleans, LA, US. Conference Note: Portions of this research were presented at the aforementioned conference. Major Descriptor: Mental Health; Mental Health Services; Natural Disasters; Posttraumatic Stress Disorder. Classification: Health & Mental Health Services (3370); Environmental Issues & Attitudes (4070). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Feb, 2008. Publication History: Accepted Date: Feb 5, 2007; Revised Date: Feb 2, 2007; First Submitted Date: Sep 18, 2006. Copyright Statement: American Psychological Association. 2008.
AB - In August 2005, Hurricane Katrina struck the Gulf Coast causing widespread residential displacement, unemployment, and compromised social networks for the residents of St. Bernard Parish, Louisiana. Symptoms of grief, depression, anxiety, posttraumatic stress, adjustment disorders, and psychosis were anecdotally reported among clinic patients during the authors' deployment to the parish in December 2005 (4 months post-Katrina). These anecdotal reports were confirmed through the analysis of survey data that were collected during the authors' follow-up visit in August 2006 (11 months post-Katrina). In collaboration with the United States Public Health Service, the parish has prioritized restoring medical and mental health services to the parish in its efforts to rebuild and repopulate. Implications for mental health practice and public policy are summarized. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - disaster
KW - mental health
KW - posttraumatic stress
KW - mental health services
KW - Hurricane Katrina
KW - 2008
KW - Mental Health
KW - Mental Health Services
KW - Natural Disasters
KW - Posttraumatic Stress Disorder
KW - 2008
DO - 10.1037/0735-7028.39.1.66
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01847-011&site=ehost-live&scope=site
UR - monica.mitchell@cchmc.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01204-001
AN - 2008-01204-001
AU - Rivard, Peter E.
AU - Luther, Stephen L.
AU - Christiansen, Cindy L.
AU - Zhao, Shibei
AU - Loveland, Susan
AU - Elixhauser, Anne
AU - Romano, Patrick S.
AU - Rosen, Amy K.
T1 - Using patient safety indicators to estimate the impact of potential adverse events on outcomes.
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2008/02//
VL - 65
IS - 1
SP - 67
EP - 87
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
N1 - Accession Number: 2008-01204-001. PMID: 18184870 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Rivard, Peter E.; VA Boston Healthcare System, Boston, MA, US. Release Date: 20080310. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Hospitalization; Safety. Minor Descriptor: Patients; Patient Safety. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Experimental Replication; Quantitative Study. References Available: Y. Page Count: 21. Issue Publication Date: Feb, 2008.
AB - The authors estimated the impact of potentially preventable patient safety events, identified by Agency for Healthcare Research and Quality (AHRQ) Patient Safety Indicators (PSIs), on patient outcomes: mortality, length of stay (LOS), and cost. The PSIs were applied to all acute inpatient hospitalizations at Veterans Health Administration (VA) facilities in fiscal 2001. Two methods--regression analysis and multivariable case matching--were used independently to control for patient and facility characteristics while predicting the effect of the PSI on each outcome. The authors found statistically significant (p < .0001) excess mortality, LOS, and cost in all groups with PSIs. The magnitude of the excess varied considerably across the PSIs. These VA findings are similar to those from a previously published study of nonfederal hospitals, despite differences between VA and non-VA systems. This study contributes to the literature measuring outcomes of medical errors and provides evidence that AHRQ PSIs may be useful indicators for comparison across delivery systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient safety indicators
KW - potential adverse events
KW - patient outcomes
KW - inpatient hospitalizations
KW - 2008
KW - Health Care Services
KW - Hospitalization
KW - Safety
KW - Patients
KW - Patient Safety
KW - 2008
U1 - Sponsor: US Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service, US. Grant: IIR-02-144-1. Recipients: No recipient indicated
DO - 10.1177/1077558707309611
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01204-001&site=ehost-live&scope=site
UR - ORCID: 0000-0001-6749-3979
UR - ORCID: 0000-0001-9951-480X
UR -
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01551-004
AN - 2008-01551-004
AU - Dworkin, Robert H.
AU - Turk, Dennis C.
AU - Wyrwich, Kathleen W.
AU - Beaton, Dorcas
AU - Cleeland, Charles S.
AU - Farrar, John T.
AU - Haythornthwaite, Jennifer A.
AU - Jensen, Mark P.
AU - Kerns, Robert D.
AU - Ader, Deborah N.
AU - Brandenburg, Nancy
AU - Burke, Laurie B.
AU - Cella, David
AU - Chandler, Julie
AU - Cowan, Penny
AU - Dimitrova, Rozalina
AU - Dionne, Raymond
AU - Hertz, Sharon
AU - Jadad, Alejandro R.
AU - Katz, Nathaniel P.
AU - Kehlet, Henrik
AU - Kramer, Lynn D.
AU - Manning, Donald C.
AU - McCormick, Cynthia
AU - McDermott, Michael P.
AU - McQuay, Henry J.
AU - Patel, Sanjay
AU - Porter, Linda
AU - Quessy, Steve
AU - Rappaport, Bob A.
AU - Rauschkolb, Christine
AU - Revicki, Dennis A.
AU - Rothman, Margaret
AU - Schmader, Kenneth E.
AU - Stacey, Brett R.
AU - Stauffer, Joseph W.
AU - von Stein, Thorsten
AU - White, Richard E.
AU - Witter, James
AU - Zavisic, Stojan
T1 - Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations.
JF - The Journal of Pain
JO - The Journal of Pain
JA - J Pain
Y1 - 2008/02//
VL - 9
IS - 2
SP - 105
EP - 121
CY - Netherlands
PB - Elsevier Science
SN - 1526-5900
AD - Dworkin, Robert H., University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY, US, 14642
N1 - Accession Number: 2008-01551-004. PMID: 18055266 Partial author list: First Author & Affiliation: Dworkin, Robert H.; Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, US. Release Date: 20080428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Pain; Clinical Trials; Pain Measurement; Treatment Effectiveness Evaluation; Treatment Outcomes. Minor Descriptor: Pain Management. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). References Available: Y. Page Count: 17. Issue Publication Date: Feb, 2008.
AB - Abstract: A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the efficacy and effectiveness of chronic pain treatments. A group of 40 participants from universities, governmental agencies, a patient self-help organization, and the pharmaceutical industry considered methodologic issues and research results relevant to determining the clinical importance of changes in the specific outcome measures previously recommended by IMMPACT for 4 core chronic pain outcome domains: (1) Pain intensity, assessed by a 0 to 10 numerical rating scale; (2) physical functioning, assessed by the Multidimensional Pain Inventory and Brief Pain Inventory interference scales; (3) emotional functioning, assessed by the Beck Depression Inventory and Profile of Mood States; and (4) participant ratings of overall improvement, assessed by the Patient Global Impression of Change scale. It is recommended that 2 or more different methods be used to evaluate the clinical importance of improvement or worsening for chronic pain clinical trial outcome measures. Provisional benchmarks for identifying clinically important changes in specific outcome measures that can be used for outcome studies of treatments for chronic pain are proposed. Perspective: Systematically collecting and reporting the recommended information needed to evaluate the clinical importance of treatment outcomes of chronic pain clinical trials will allow additional validation of proposed benchmarks and provide more meaningful comparisons of chronic pain treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chronic pain
KW - clinical importance
KW - treatment outcomes
KW - efficacy & effectiveness of treatments
KW - clinical trials
KW - IMMPACT recommendations
KW - 2008
KW - Chronic Pain
KW - Clinical Trials
KW - Pain Measurement
KW - Treatment Effectiveness Evaluation
KW - Treatment Outcomes
KW - Pain Management
KW - 2008
U1 - Sponsor: Allergan. Other Details: Unrestricted grants,University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Alpharma. Recipients: No recipient indicated
U1 - Sponsor: AstraZeneca. Recipients: No recipient indicated
U1 - Sponsor: Celgene. Recipients: No recipient indicated
U1 - Sponsor: Elan. Recipients: No recipient indicated
U1 - Sponsor: Endo. Recipients: No recipient indicated
U1 - Sponsor: GlaxoSmithKline. Recipients: No recipient indicated
U1 - Sponsor: Johnson & Johnson. Recipients: No recipient indicated
U1 - Sponsor: Merck. Recipients: No recipient indicated
U1 - Sponsor: NeurogesX. Recipients: No recipient indicated
U1 - Sponsor: Pfizer. Recipients: No recipient indicated
U1 - Sponsor: Purdue. Recipients: No recipient indicated
U1 - Sponsor: Schwarz Biosciences. Recipients: No recipient indicated
DO - 10.1016/j.jpain.2007.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01551-004&site=ehost-live&scope=site
UR - robert_dworkin@urmc.rochester.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01007-005
AN - 2008-01007-005
AU - Jansen, Wilma
AU - van de Looij-Jansen, Petra M.
AU - de Wilde, Erik J.
AU - Brug, Johannes
T1 - Feeling fat rather than being fat may be associated with psychological well-being in young Dutch adolescents.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2008/02//
VL - 42
IS - 2
SP - 128
EP - 136
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Jansen, Wilma, GGD Rotterdam-Rijnmond, Postbus 70032, 3000 LP, Rotterdam, Netherlands
N1 - Accession Number: 2008-01007-005. PMID: 18207090 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Jansen, Wilma; Department of Public Health, Erasmus MC, Rotterdam, Netherlands. Release Date: 20080211. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Body Weight; Obesity; Weight Perception; Well Being. Minor Descriptor: Psychosocial Factors. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Short Depression Inventory for Children; Dutch Social Anxiety Scale for Children; Rotterdam Youth Health Monitor Questionnaire; Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Feb, 2008.
AB - Purpose: To contribute to a further exploration of the association of psychosocial well-being with overweight and weight perception among young Dutch adolescents. Methods: Data from the ongoing Rotterdam Youth Health Monitor were used from 1,923 9-10-year-olds and 3,841 12-13-year-olds. The association of mental health indicators with weight status based on self-report and measured height and weight was studied with logistic regression analyses in both age groups cross-sectionally. Additional longitudinal analyses were conducted among the 787 pupils for whom follow-up data were available. Interactions with gender and ethnic background were explored. Among the 12-13-year-olds, the role of weight perception was also studied. Results: We found that 9-10-year-old obese boys scored more favourably on social anxiety than nonoverweight boys. Among 12-13-year-olds body weight perception, rather than self-reported or measured weight status was associated with mental health indicators. Mental health indicators at age 9-10 years did not predict self-reported weight status at age 12-13 or change in weight status between 9-10 and 12-13 years, nor did weight status at age 9-10 years predict later mental health indicators or change in these indicators. Conclusions: This study provides no evidence that overweight does coincide with less favorable psychological well-being in young adolescents. In 12-13-year-old adolescents, feeling overweight, rather than being overweight, appears to be important. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fat
KW - psychological well-being
KW - young Dutch adolescents
KW - psychosocial well-being
KW - overweight
KW - weight perception
KW - 2008
KW - Adolescent Development
KW - Body Weight
KW - Obesity
KW - Weight Perception
KW - Well Being
KW - Psychosocial Factors
KW - 2008
DO - 10.1016/j.jadohealth.2007.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01007-005&site=ehost-live&scope=site
UR - jansenw@ggd.rotterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01534-006
AN - 2008-01534-006
AU - Amitai, Yona
AU - Fisher, Nirah
AU - Meiraz, Hana
AU - Baram, Nira
AU - Tounis, Marie
AU - Leventhal, Alex
T1 - Preconceptional folic acid utilization in Israel: Five years after the guidelines.
JF - Preventive Medicine: An International Journal Devoted to Practice and Theory
JO - Preventive Medicine: An International Journal Devoted to Practice and Theory
JA - Prev Med
Y1 - 2008/02//
VL - 46
IS - 2
SP - 166
EP - 169
CY - Netherlands
PB - Elsevier Science
SN - 0091-7435
AD - Fisher, Nirah, Department of Maternal Child and Adolescent Health, Ministry of Health, 20 King David St., Jerusalem, Israel, 91010
N1 - Accession Number: 2008-01534-006. PMID: 17961644 Other Journal Title: Preventative Medicine: An International Journal Devoted to Practice & Theory. Partial author list: First Author & Affiliation: Amitai, Yona; Department of Maternal, Child and Adolescent Health, Ministry of Health, Jerusalem, Israel. Release Date: 20080505. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dietary Supplements; Folic Acid; Health Behavior; Health Promotion; Public Health. Minor Descriptor: Human Females; Nutrition; Public Health Services. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Location: Israel. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Feb, 2008.
AB - Objective: In Israel, a national survey was conducted in order to assess the efficacy of the ongoing national folic acid (FA) campaign launched in 2000. The Ministry of Health had issued official guidelines in August 2000 recommending daily FA supplementation for all childbearing age women. Methods: In 2005, structured interviews of pregnant and postpartum women were conducted by the nursing staff of the Maternal Child Health Clinics administered by the Public Health Service. The results of the 2005 survey are compared with similar surveys done in 2002 and 2000 (baseline). Results: In the 2005 survey (n=1860), FA awareness, knowledge, timing knowledge and preconceptional utilization were 90.3%, 80.8%, 74.6% and 34.0%, respectively. Education was significantly associated with compliance: only 13.6% of women with <12 years of education utilized FA preconceptionally versus 48.1% of women with ≥16 years. In the 2002 survey (n=1661), FA awareness, knowledge, and preconceptional utilization were 85%, 77.7% and 30.5%, respectively. In the 2000 survey (n=1719), FA awareness was 54.6%, knowledge was 17.6% and preconceptional utilization was 5.2%. Conclusions: The national preconceptional FA campaign in Israel has resulted in significant increases in awareness, knowledge and preconceptional utilization. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preconception folic acid
KW - public health program
KW - Israel
KW - women
KW - 2008
KW - Dietary Supplements
KW - Folic Acid
KW - Health Behavior
KW - Health Promotion
KW - Public Health
KW - Human Females
KW - Nutrition
KW - Public Health Services
KW - 2008
DO - 10.1016/j.ypmed.2007.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01534-006&site=ehost-live&scope=site
UR - nirah.fisher@moh.health.gov.il
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01385-011
AN - 2008-01385-011
AU - Baum, A. E.
AU - Akula, N.
AU - Cabanero, M.
AU - Cardona, I.
AU - Corona, W.
AU - Klemens, B.
AU - Schulze, T. G.
AU - Cichon, S.
AU - Rietschel, M.
AU - Nöthen, M. M.
AU - Georgi, A.
AU - Schumacher, J.
AU - Schwarz, M.
AU - Jamra, R. Abou
AU - Höfels, S.
AU - Propping, P.
AU - Satagopan, J.
AU - Detera-Wadleigh, S. D.
AU - Hardy, J.
AU - McMahon, F. J.
T1 - A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2008/02//
VL - 13
IS - 2
SP - 197
EP - 207
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - McMahon, F. J., Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, 1A-202, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-01385-011. PMID: 17486107 Partial author list: First Author & Affiliation: Baum, A. E.; Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, US Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Institutional Authors: NIMH Genetics Initiative Bipolar Disorder Consortium. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Schulze, T. G. Major Descriptor: Bipolar Disorder; Etiology; Genes. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: Germany. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Web Sites Internet. References Available: Y. Page Count: 11. Issue Publication Date: Feb, 2008.
AB - The genetic basis of bipolar disorder has long been thought to be complex, with the potential involvement of multiple genes, but methods to analyze populations with respect to this complexity have only recently become available. We have carried out a genome-wide association study of bipolar disorder by genotyping over 550000 single-nucleotide polymorphisms (SNPs) in two independent case-control samples of European origin. The initial association screen was performed using pooled DNA, and selected SNPs were confirmed by individual genotyping. While DNA pooling reduces power to detect genetic associations, there is a substantial cost saving and gain in efficiency. A total of 88 SNPs, representing 80 different genes, met the prior criteria for replication in both samples. Effect sizes were modest: no single SNP of large effect was detected. Of 37 SNPs selected for individual genotyping, the strongest association signal was detected at a marker within the first intron of diacylglycerol kinase eta (DGKH; P = 1.5 × 10-8, experiment-wide P < 0.01, OR = 1.59). This gene encodes DGKH, a key protein in the lithium-sensitive phosphatidyl inositol pathway. This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mania
KW - bipolar disorder
KW - etiology
KW - genes
KW - 2008
KW - Bipolar Disorder
KW - Etiology
KW - Genes
KW - 2008
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: No recipient indicated
U1 - Sponsor: Deutsche Forschungsgemeinschaft, Germany. Recipients: No recipient indicated
U1 - Sponsor: Federal Ministry of Education and Research, National German Genome Research Network, Germany. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: Schulze, T. G.; McMahon, F. J.
U1 - Sponsor: Alfried Krupp Von Bohlen Und Halbach-Stiftung. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: R01GM60457; R01CA098438. Recipients: Satagopan, J.
DO - 10.1038/sj.mp.4002012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01385-011&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR - ORCID: 0000-0001-7102-5633
UR - ORCID: 0000-0002-1499-8524
UR - ORCID: 0000-0002-9475-086X
UR -
UR - mcmahonf@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-00296-007
AN - 2008-00296-007
AU - Bellamy, Jennifer L.
T1 - Behavioral problems following reunification of children in long-term foster care.
JF - Children and Youth Services Review
JO - Children and Youth Services Review
JA - Child Youth Serv Rev
Y1 - 2008/02//
VL - 30
IS - 2
SP - 216
EP - 228
CY - Netherlands
PB - Elsevier Science
SN - 0190-7409
AD - Bellamy, Jennifer L., Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1093, One Brookings Drive, St. Louis, MO, US, 63130-4899
N1 - Accession Number: 2008-00296-007. PMID: 19190714 Partial author list: First Author & Affiliation: Bellamy, Jennifer L.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20080128. Correction Date: 20130520. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Behavior Problems; Childhood Development; Family Reunification; Foster Care; Risk Factors. Minor Descriptor: Adolescent Development; Long Term Care; Well Being. Classification: Behavior Disorders & Antisocial Behavior (3230); Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Tests & Measures: Child Behavior Checklist; Conflict Tactics Scales DOI: 10.1037/t02125-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Feb, 2008.
AB - Although reunification is the most common and preferred exit from the U.S. foster care system, little is known about the well-being of children following foster care. Even less is known about reunification following long-term foster care. Geographically limited studies suggest poor behavioral outcomes following reunification. A secondary data analysis was performed using a subsample of 604 children from the National Study of Child and Adolescent Well-being (NSCAW) who had experienced at least 8 months of foster care. Multiple imputation (MI) was employed to address missing data. Descriptive statistics, logistic regression, and propensity score matching are used to explore the role of risks and reunification in children's well-being from baseline to 36-month follow-up. Results indicate that reunification has no direct effect on behavioral outcomes, but is associated with increased risks in the family context of children who are reunified. Findings highlight the complex nature of the relationship between reunification and behavioral outcomes, as well as the need for reunification interventions that specifically target parental mental health and children's internalizing behaviors. Reunification research using longitudinal data and qualitative methods is recommended to clarify risks and outcomes across time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral problems
KW - children
KW - long term foster care
KW - reunification
KW - well being
KW - risk factors
KW - 2008
KW - Behavior Problems
KW - Childhood Development
KW - Family Reunification
KW - Foster Care
KW - Risk Factors
KW - Adolescent Development
KW - Long Term Care
KW - Well Being
KW - 2008
U1 - Sponsor: Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health. Grant: 5P30 MH068579; 05T32MH01996012. Recipients: No recipient indicated
U1 - Sponsor: International Order of the Odd Fellows. Recipients: No recipient indicated
U1 - Sponsor: Center for the Study of Social Work Practice. Recipients: No recipient indicated
U1 - Sponsor: Columbia University School of SocialWork/Jewish Board of Family and Children's Services. Recipients: No recipient indicated
U1 - Sponsor: New York Foundling, Vincent J. Fontana Center for Child Protection Dissertation. Recipients: No recipient indicated
DO - 10.1016/j.childyouth.2007.09.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-00296-007&site=ehost-live&scope=site
UR - jbellamy@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01784-008
AN - 2008-01784-008
AU - Hellinger, Fred
T1 - Practice makes perfect: A volume-outcome study of hospital patients with HIV disease.
JF - JAIDS Journal of Acquired Immune Deficiency Syndromes
JO - JAIDS Journal of Acquired Immune Deficiency Syndromes
JA - J Acquir Immune Defic Syndr Hum Retrovirol
Y1 - 2008/02//
VL - 47
IS - 2
SP - 226
EP - 233
CY - US
PB - Lippincott Williams & Wilkins
SN - 1525-4135
SN - 1077-9450
AD - Hellinger, Fred, Agency for Healthcare Research and Quality, Rockville, MD, US, 20850
N1 - Accession Number: 2008-01784-008. Partial author list: First Author & Affiliation: Hellinger, Fred; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20080825. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; HIV; Hospitalized Patients. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Feb, 2008.
AB - Objective: There is considerable evidence that patients with HIV fare better in hospitals that treat more HIV-positive patients. Yet, it is possible that much of this benefit is attributable to the care provided by physicians who treat high volumes of HIV-positive patients. This study examines the relation between 2 measures of volume (the number of HIV-positive patients treated in a hospital and the number of HIV-positive patients treated by the attending physician) and the probability of dying in the hospital. Data: This study uses discharge data from 43,325 patients hospitalized with HIV disease in 5 states (Colorado, Maryland, New Jersey, New York, and Washington State) in 2002. These data were obtained from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project State Inpatient Databases. Study Design: Volume-outcome studies have demonstrated an inverse relation between the number of HIV-positive patients treated at a hospital and the mortality rate for these patients. Yet, the most current of these studies is based on data more than a decade old, and none of these account for the volume of HIV-positive patients treated by the physician. This study uses multivariate logistic regression analyses to estimate the impact of hospital and physician volume on patient mortality. Results: This study found that when measures of physician and hospital volume are included in a regression equation explaining patient mortality, only the variable measuring physician volume remains statistically significant. Moreover, when a variable is defined for each patient based on the quartile rankings of the patient's hospital volume and the patient's physician volume, the quartile ranking of physician volume is a better predictor of survival than the quartile ranking of hospital volume. Conclusion: These findings suggest that the volume of patients treated by the attending physician is the key measure of volume associated with the survival of hospitalized HIV-positive patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospital patients
KW - HIV disease
KW - volume-outcome
KW - dying
KW - 2008
KW - Death and Dying
KW - HIV
KW - Hospitalized Patients
KW - 2008
DO - 10.1097/QAI.0b013e31815e402a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01784-008&site=ehost-live&scope=site
UR - fhelling@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Mattia, Antonia
AU - Merker, Robert
T1 - Regulation of Probiotic Substances as Ingredients in Foods: Premarket Approval or "Generally Recognized as Safe" Notification.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/02/02/2/1/2008 Supplement 2
VL - 46
M3 - Article
SP - S115
EP - S118
SN - 10584838
AB - This article discusses options and examples of regulations or "generally recognized as safe" determinations that are related to microorganisms in food. A balanced picture of information about the microorganism and its characteristics is needed to make conclusions about its safety. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food
KW - Safety
KW - Microorganisms
KW - Dietary supplements
KW - Biological products
KW - Probiotics
N1 - Accession Number: 30031327; Mattia, Antonia 1; Email Address: antonia.mattia@fda.hhsgov; Merker, Robert 2; Affiliations: 1: Division of Biotechnology and GRAS Notice Review, College Park, Maryland; 2: Division of Petition Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland; Issue Info: 2/1/2008 Supplement 2, Vol. 46, pS115; Thesaurus Term: Food; Thesaurus Term: Safety; Thesaurus Term: Microorganisms; Thesaurus Term: Dietary supplements; Thesaurus Term: Biological products; Subject Term: Probiotics; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1086/523329
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=30031327&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roseland, Janet M.
AU - Holden, Joanne M.
AU - Andrews, Karen W.
AU - Zhao, Cuiwei
AU - Schweitzer, Amy
AU - Harnly, James
AU - Wolf, Wayne R.
AU - Perry, Charles R.
AU - Dwyer, Johanna T.
AU - Picciano, Mary Frances
AU - Betz, Joseph M.
AU - Saldanha, Leila G.
AU - Yetley, Elizabeth A.
AU - Fisher, Kenneth D.
AU - Sharpless, Katherine E.
T1 - Dietary supplement ingredient database (DSID): Preliminary USDA studies on the composition of adult multivitamin/mineral supplements
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2008/02/02/Feb2008 Supplement
VL - 21
M3 - Article
SP - S69
EP - S77
SN - 08891575
AB - Abstract: The Nutrient Data Laboratory of the United States Department of Agriculture (USDA) is collaborating with the Office of Dietary Supplements (ODS), the National Center for Health Statistics (NCHS), and other government agencies to design and populate a dietary supplement ingredient database (DSID). This analytically based, publicly available database will provide reliable estimates of vitamin and mineral content of dietary supplement (DS) products. The DSID will initially be populated with multivitamin/mineral (MVM) products because they are the most commonly consumed supplements. Challenges associated with the analysis of MVMs were identified and investigated. A pilot study addressing the identification of appropriate analytical methods, sample preparation protocols, and experienced laboratories for the analysis of 12 vitamins and 11 minerals in adult MVM supplement products was completed. Preliminary studies support the development of additional analytical studies with results that can be applied to the DSID. Total intakes from foods and supplements are needed to evaluate the associations between dietary components and health. The DSID will provide better estimates of actual nutrient intake from supplements than databases that rely on label values alone. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - DATABASES
KW - MINERALS in nutrition
KW - FOOD -- Analysis
KW - Analytical database
KW - Dietary supplements
KW - DSID
KW - Multivitamin
KW - Nutrients
KW - Pilot study
N1 - Accession Number: 27336109; Roseland, Janet M. 1; Email Address: janet.roseland@ars.usda.gov Holden, Joanne M. 1 Andrews, Karen W. 1 Zhao, Cuiwei 1 Schweitzer, Amy 1 Harnly, James 2 Wolf, Wayne R. 2 Perry, Charles R. 3 Dwyer, Johanna T. 4 Picciano, Mary Frances 4 Betz, Joseph M. 4 Saldanha, Leila G. 4 Yetley, Elizabeth A. 4 Fisher, Kenneth D. 4 Sharpless, Katherine E. 5; Affiliation: 1: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705, USA 2: Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD, USA 3: Research and Development Division, National Agricultural Statistics Service, US Department of Agriculture, Fairfax, VA, USA 4: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA 5: National Institute of Standards and Technology, Gaithersburg, MD, USA; Source Info: Feb2008 Supplement, Vol. 21, pS69; Subject Term: DIETARY supplements; Subject Term: DATABASES; Subject Term: MINERALS in nutrition; Subject Term: FOOD -- Analysis; Author-Supplied Keyword: Analytical database; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: DSID; Author-Supplied Keyword: Multivitamin; Author-Supplied Keyword: Nutrients; Author-Supplied Keyword: Pilot study; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2007.07.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27336109&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dwyer, Johanna T.
AU - Frances Picciano, Mary
AU - Betz, Joseph M.
AU - Fisher, Kenneth D.
AU - Saldanha, Leila G.
AU - Yetley, Elizabeth A.
AU - Coates, Paul M.
AU - Milner, John A.
AU - Whitted, Jackie
AU - Burt, Vicki
AU - Radimer, Kathy
AU - Wilger, Jaimie
AU - Sharpless, Katherine E.
AU - Holden, Joanne M.
AU - Andrews, Karen
AU - Roseland, Janet
AU - Zhao, Cuiwei
AU - Schweitzer, Amy
AU - Harnly, James
AU - Wolf, Wayne R.
T1 - Progress in developing analytical and label-based dietary supplement databases at the NIH Office of Dietary Supplements
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2008/02/02/Feb2008 Supplement
VL - 21
M3 - Article
SP - S83
EP - S93
SN - 08891575
AB - Abstract: Although an estimated 50% of adults in the United States consume dietary supplements, analytically substantiated data on their bioactive constituents are sparse. Several programs funded by the Office of Dietary Supplements (ODS) at the National Institutes of Health enhance dietary supplement database development and help to better describe the quantitative and qualitative contributions of dietary supplements to total dietary intakes. ODS, in collaboration with the United States Department of Agriculture, is developing a Dietary Supplement Ingredient Database (DSID) verified by chemical analysis. The products chosen initially for analytical verification are adult multivitamin-mineral supplements (MVMs). These products are widely used, analytical methods are available for determining key constituents, and a certified reference material is in development. Also MVMs have no standard scientific, regulatory, or marketplace definitions and have widely varying compositions, characteristics, and bioavailability. Furthermore, the extent to which actual amounts of vitamins and minerals in a product deviate from label values is not known. Ultimately, DSID will prove useful to professionals in permitting more accurate estimation of the contribution of dietary supplements to total dietary intakes of nutrients and better evaluation of the role of dietary supplements in promoting health and well-being. ODS is also collaborating with the National Center for Health Statistics to enhance the National Health and Nutrition Examination Survey dietary supplement label database. The newest ODS effort explores the feasibility and practicality of developing a database of all dietary supplement labels marketed in the US. This article describes these and supporting projects. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - DATABASES
KW - FOOD -- Composition
KW - FOOD -- Analysis
KW - Analytical substantiation
KW - Certified reference materials
KW - Dietary supplement composition
KW - Dietary supplement ingredient database
KW - Dietary supplement labels
KW - Dietary supplements
KW - DSID
KW - DSLD-USA
KW - NHANES
KW - NHANES-DSLD
KW - Standard reference materials®
N1 - Accession Number: 27336111; Dwyer, Johanna T. 1; Email Address: dwyerj1@od.nih.gov Frances Picciano, Mary 1 Betz, Joseph M. 1 Fisher, Kenneth D. 1 Saldanha, Leila G. 1 Yetley, Elizabeth A. 1 Coates, Paul M. 1 Milner, John A. 2 Whitted, Jackie 2 Burt, Vicki 3 Radimer, Kathy 3 Wilger, Jaimie 3 Sharpless, Katherine E. 4 Holden, Joanne M. 5 Andrews, Karen 5 Roseland, Janet 5 Zhao, Cuiwei 5 Schweitzer, Amy 5 Harnly, James 6 Wolf, Wayne R. 6; Affiliation: 1: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA 2: Nutritional Sciences Research Group, National Cancer Institute, US DHHS, Bethesda, MD, USA 3: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control and Prevention, US DHHS, Hyattsville, MD, USA 4: National Institute of Standards and Technology, Gaithersburg, MD, USA 5: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA 6: Food Composition Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, Beltsville, MD, USA; Source Info: Feb2008 Supplement, Vol. 21, pS83; Subject Term: DIETARY supplements; Subject Term: DATABASES; Subject Term: FOOD -- Composition; Subject Term: FOOD -- Analysis; Author-Supplied Keyword: Analytical substantiation; Author-Supplied Keyword: Certified reference materials; Author-Supplied Keyword: Dietary supplement composition; Author-Supplied Keyword: Dietary supplement ingredient database; Author-Supplied Keyword: Dietary supplement labels; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: DSID; Author-Supplied Keyword: DSLD-USA; Author-Supplied Keyword: NHANES; Author-Supplied Keyword: NHANES-DSLD; Author-Supplied Keyword: Standard reference materials®; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2007.07.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 108188984
T1 - Now and then: combat casualty care policies for Operation Iraqi Freedom and Operation Enduring Freedom compared with those of Vietnam.
AU - Cordts PR
AU - Brosch LA
AU - Holcomb JB
Y1 - 2008/02/02/2008 Supplement
N1 - Accession Number: 108188984. Language: English. Entry Date: 20120316. Revision Date: 20150712. Publication Type: Journal Article. Supplement Title: 2008 Supplement. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Critical Care; Emergency Care. NLM UID: 0376373.
KW - Military Medicine
KW - Military Medicine -- History
KW - Practice Guidelines
KW - War
KW - Wounds and Injuries -- Therapy
KW - History
KW - Research, Medical
KW - United States
KW - Wounds and Injuries -- Etiology
KW - Wounds and Injuries -- History
SP - S14
EP - 20
JO - Journal of Trauma
JF - Journal of Trauma
JA - J TRAUMA
VL - 64
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Between December 2004 and June 2007, 13 key Operation Iraqi Freedom/Operation Enduring Freedom combat casualty care policies were published to inform medical practice in the combat theater of operations. Published policies were authored by the 44th Medical Command (1), the Office of The Army Surgeon General (11), and the Office of the Assistant Secretary of Defense (Health Affairs) (1). These policies, published as an All Army Action message (and/or in memorandum format signed by The Army Surgeon General), were compared with published medical newsletters and medical bulletins issued during the Vietnam War era, beginning in 1966. Common to both wartime eras was the recognition that the presence of a medical research team in theater was a critical element to ensure accurate data capture for subsequent analysis, to document lessons learned, and to study the impact of new wounding mechanisms, whether it be the Pungi sticks and mines of Vietnam or the types of explosions specific to Operation Iraqi Freedom/Operation Enduring Freedom. It is important to recognize that both then and now, medical practice has been a reflection of the current state of medical practice, and that in both conflicts military medical personnel have been equally devoted to saving lives of combat casualties.
SN - 0022-5282
AD - Health Policy and Services, Office of The Surgeon General, 5109 Leesburg Pike, Falls Church, VA 22041, USA. paul.cordts@amedd.army.mil
U2 - PMID: 18376157.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Woo, Jong Soo
AU - Song, Yun-Kyoung
AU - Hong, Ji-Yeon
AU - Lim, Soo-Jeong
AU - Kim, Chong-Kook
T1 - Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
Y1 - 2008/02/05/
VL - 33
IS - 2
M3 - Article
SP - 159
EP - 165
SN - 09280987
AB - Abstract: Self-microemulsifying drug delivery systems (SMEDDS) represent a possible alternative to traditional oral formulations of lipophilic compounds. This study was designed to compare the oral bioavailability and food-effect of SMEDDS of itraconazole (ITRA-GSMP capsule containing 50mg itraconazole) to that of the currently marketed formulation (Sporanox capsule containing 100mg itraconazole). Eight healthy volunteers received Sporanox or ITRA-GSMP capsule in the fasted state or after a high-fat diet on four separate dosing occasions with a 2-week washout period. Blood samples were collected and analyzed. After administration of the ITRA-GSMP capsule, AUC0–24 and C max were 1.9- and 2.5-fold higher in the fasted state and 1.5- and 1.3-fold higher in the fed state, respectively, than those of the Sporanox capsule. Moreover, ITRA-GSMP capsules yielded more reproducible blood-time profiles than Sporanox capsules. Food had a marked effect on itraconazole absorption from the Sporanox capsule, whereas the influence was less pronounced for the ITRA-GSMP capsule. Collectively, our data suggest that a new self-microemulsifying formulation may provide an alternative oral formulation for itraconazole with improved oral bioavailability and reduced food-effect. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMISTRY
KW - DRUG delivery systems
KW - PHARMACEUTICAL technology
KW - BIOAVAILABILITY
KW - Bioavailability
KW - Food-effect
KW - Itraconazole
KW - Self-microemulsifying drug delivery systems
N1 - Accession Number: 28800733; Woo, Jong Soo 1 Song, Yun-Kyoung 2,3 Hong, Ji-Yeon 2 Lim, Soo-Jeong 4 Kim, Chong-Kook 2; Email Address: ckkim@plaza.snu.ac.kr; Affiliation: 1: Pharmaceutical Research Center, Hanmi Pharm Co., Ltd., Paltan-myeon, #893-5 Hwaseong-si, Gyeonggi-do, 445-913, Republic of Korea 2: Laboratory of Excellency for Drug and Gene Delivery, College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Kwanak-gu, Seoul 151-742, Republic of Korea 3: Narcotics and Neuropharmacology Drug Team, Department of Drug Evaluation, Korea Food and Drug Administration, #194 Tongilro, Eunpyung-gu, Seoul 122-704, Republic of Korea 4: Department of Bioscience and Biotechnology, Sejong University, #98 Gunja-dong, Gwangjin-gu, Seoul 143-747, Republic of Korea; Source Info: Feb2008, Vol. 33 Issue 2, p159; Subject Term: BIOCHEMISTRY; Subject Term: DRUG delivery systems; Subject Term: PHARMACEUTICAL technology; Subject Term: BIOAVAILABILITY; Author-Supplied Keyword: Bioavailability; Author-Supplied Keyword: Food-effect; Author-Supplied Keyword: Itraconazole; Author-Supplied Keyword: Self-microemulsifying drug delivery systems; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ejps.2007.11.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28800733&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gabry, Kay Eddie
T1 - THE SCIENCE OF ORGASM.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/02/13/
VL - 299
IS - 6
M3 - Book Review
SP - 701
EP - 702
SN - 00987484
AB - The article reviews the book "The Science of Orgasm" by Barry R. Komisaruk, Carlos Beyer-Flores and Beverly Whipple.
KW - ORGASM
KW - NONFICTION
KW - BEYER-Flores, Carlos
KW - WHIPPLE, Beverly
KW - KOMISARUK, Barry R.
KW - SCIENCE of Orgasm, The (Book)
N1 - Accession Number: 29979858; Gabry, Kay Eddie 1; Email Address: kamal.gabry@fda.hhs.gov; Affiliation: 1: Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring, Maryland; Source Info: 2/13/2008, Vol. 299 Issue 6, p701; Subject Term: ORGASM; Subject Term: NONFICTION; Reviews & Products: SCIENCE of Orgasm, The (Book); People: BEYER-Flores, Carlos; People: WHIPPLE, Beverly; People: KOMISARUK, Barry R.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, Rakhi B.
AU - Prasanna, Hullahalli R.
AU - Rothman, Barry
AU - Khan, Mansoor A.
T1 - Stability of ranitidine syrup repackaged in unit-dose containers.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2008/02/15/
VL - 65
IS - 4
M3 - Article
SP - 325
EP - 329
PB - American Society of Health System Pharmacists
SN - 10792082
AB - The article examines the stability of ranitidine syrup repackage in unit-dose containers. Stability was determined using the high-performance liquid chromatography. The occurring hydrogen-ion concentration (ph) changes, sample weight and the principal impurities were also measured. Hence, repackaged oral ranitidine hydrochloride syrup is highly dependent on storage temperature and on the given relative humidity within a given duration in maintaining its efficacy.
KW - DRUG stability
KW - RANITIDINE
KW - PACKAGING
KW - CHROMATOGRAPHIC analysis
KW - TEMPERATURE control
KW - HYDROGEN-ion concentration
N1 - Accession Number: 31142371; Shah, Rakhi B. 1 Prasanna, Hullahalli R. 2 Rothman, Barry 3 Khan, Mansoor A. 4; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Pharmacologist, Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research (CDER) 2: Chemist, Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research (CDER) 3: Consumer Safety Officer, Division of Manufacturing and Product Quality, Office of Compliance, CDER 4: Director, Division of Product Quality Research, Office of Testing and Research, CDER, Food and Drug Administration, Silver Spring, MD; Source Info: 2/15/2008, Vol. 65 Issue 4, p325; Subject Term: DRUG stability; Subject Term: RANITIDINE; Subject Term: PACKAGING; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: TEMPERATURE control; Subject Term: HYDROGEN-ion concentration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; Number of Pages: 5p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.2146/ajhp060625
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105860071
T1 - Stability of ranitidine syrup re-packaged in unit-dose containers.
AU - Shah RB
AU - Prasanna HR
AU - Rothman B
AU - Khan MA
Y1 - 2008/02/15/
N1 - Accession Number: 105860071. Language: English. Entry Date: 20080314. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Drug Packaging
KW - Gastrointestinal Agents
KW - Ranitidine
KW - Chromatography, High Pressure Liquid
KW - Drug Stability
KW - Drug Storage
KW - Temperature
KW - Time Factors
SP - 325
EP - 329
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 65
IS - 4
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
AB - PURPOSE: The stability of ranitidine syrup re-packaged in unit-dose containers was studied. METHODS: Oral ranitidine hydrochloride syrup containing 16.8 mg/mL of ranitidine hydrochloride (equivalent to 15 mg of ranitidine) in original bulk containers and re-packaged in unit-dose amber-colored glass bottles sealed with aluminum caps were obtained from commercial sources. For extended-stability determinations, samples were stored for 52 weeks at 25 degrees C and 40% relative humidity and analyzed at 0, 4, 13, 26, 39, and 52 weeks. For accelerated stability determinations, samples were stored for 13 weeks at 40 degrees C and 25% relative humidity and analyzed at 0, 4, 9, and 13 weeks. Stability was assessed using high-performance liquid chromatography and by measuring changes in pH and sample weight. The principal impurity and total impurities were also measured. RESULTS: No significant changes in pH were demonstrated, and all values remained well within acceptable limits. The weight change in samples was greater for re-packaged samples stored in accelerated conditions compared with that of samples in the original packaging; however, the differences were not significant. Ranitidine hydrochloride samples in both types of packaging remained stable when stored at 25 degrees C and 40% relative humidity for 52 weeks and at 40 degrees C and 25% relative humidity for 13 weeks. The impurity profiles remained within acceptable limits for all samples. CONCLUSION: Re-packaged ranitidine syrup was stable for up to 52 weeks when stored at 25 degrees C and 40% relative humidity and for up to 13 weeks when stored at 40 degrees C and 25% relative humidity.
SN - 1079-2082
AD - Office of Testing and Research, Center for Drug Evaluation and Research (CDER), Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-002, USA.
U2 - PMID: 18238770.
DO - 10.2146/ajhp060625
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Valentin-Bon, Iris
AU - Jacobson, Andrew
AU - Monday, Steven R.
AU - Feng, Peter C. H.
T1 - Microbiological Quality of Bagged Cut Spinach and Lettuce Mixes.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/02/15/
VL - 74
IS - 4
M3 - Article
SP - 1240
EP - 1242
SN - 00992240
AB - Analysis of 100 bagged lettuce and spinach samples showed mean total bacterial counts of 7.0 log10 CFU/g and a broad range of < to 8.3 log10 CFU/g. Most probable numbers (MPN) of ≥11,000 /g coliforms were found in 55 samples, and generic Escherichia coli bacteria were detected in 16 samples, but no E. coli count exceeded 10 MPN/g. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIOLOGY
KW - BACTERIA
KW - PACKAGED foods
KW - EDIBLE greens
KW - SPINACH
KW - LETTUCE
N1 - Accession Number: 31156268; Valentin-Bon, Iris 1 Jacobson, Andrew 1 Monday, Steven R. 1 Feng, Peter C. H. 1; Email Address: peter.feng@fda.hhs.gov; Affiliation: 1: Division of Microbiology, United States Food and Drug Administration, College Park, Maryland 20740; Source Info: Feb2008, Vol. 74 Issue 4, p1240; Subject Term: MICROBIOLOGY; Subject Term: BACTERIA; Subject Term: PACKAGED foods; Subject Term: EDIBLE greens; Subject Term: SPINACH; Subject Term: LETTUCE; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 424420 Packaged Frozen Food Merchant Wholesalers; Number of Pages: 3p; Illustrations: 1 Black and White Photograph, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105892249
T1 - Avoidable hospitalizations in patients with systemic lupus erythematosus.
AU - Ward MM
Y1 - 2008/02/15/
N1 - Accession Number: 105892249. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0370605.
KW - Hospitalization -- Statistics and Numerical Data
KW - Lupus Erythematosus, Systemic -- Epidemiology
KW - Lupus Erythematosus, Systemic -- Therapy
KW - Adult
KW - Aged
KW - Bed Occupancy -- Statistics and Numerical Data
KW - Cellulitis -- Epidemiology
KW - Cellulitis -- Therapy
KW - Demography
KW - Female
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Heart Failure -- Epidemiology
KW - Heart Failure -- Therapy
KW - Male
KW - Medically Underserved Area
KW - Middle Age
KW - Multivariate Analysis
KW - New York
KW - Pneumonia -- Epidemiology
KW - Pneumonia -- Therapy
KW - Poverty
KW - Risk Factors
KW - Human
SP - 162
EP - 168
JO - Arthritis & Rheumatism: Arthritis Care & Research
JF - Arthritis & Rheumatism: Arthritis Care & Research
JA - ARTHRITIS RHEUM (ARTHRITIS CARE RES)
VL - 59
IS - 2
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AD - Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland.
U2 - PMID: 18240192.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Soon-Tae
AU - Park, Jung-Eun
AU - Kim, Dong-Hyun
AU - Kim, Seungchan
AU - Im, Woo-Seok
AU - Kang, Lami
AU - Jung, Se Hee
AU - Kim, Min-Wook
AU - Chu, Kon
AU - Kim, Manho
T1 - Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease
JO - Brain Research
JF - Brain Research
Y1 - 2008/02/15/
VL - 1194
M3 - Article
SP - 130
EP - 137
SN - 00068993
AB - Abstract: Huntington''s disease (HD) has a mitochondrial dysfunction causing the vulnerability to the excitotoxicity and activations of multiple cell death pathways. Recent evidences suggest that the hematopoietic cytokine, granulocyte-colony stimulating factor (G-CSF), exerts pleiotropic neuroprotection in acute neural injury with activating various survival pathways. Thus, we investigated whether G-CSF can modulate neurodegeneration in an HD animal model induced by 3-nitropropionic acid (3NP), which inhibits mitochondrial succinate dehydrogenase complex II. Either G-CSF (50 μg/kg/day) or saline (as vehicle) was administered intraperitoneally for 5 days with 3NP (63 mg/kg/day) continuous osmotic pump infusion into male Lewis rats. We measured motor scales (0–8) daily and sacrificed rats at 5 days. We observed that G-CSF receptors were expressed in 3NP-induced degenerating striatum. Rats treated with G-CSF showed less degree of neurologic deficits. In the G-CSF-treated rats, the striatal lesion volume measured by Nissl staining, TUNEL+ apoptotic cells, Fluorojade C+ degenerating neurons, and c-Jun+ cells were all decreased. In western blotting, G-CSF activated survival pathways including p-ERK, p-eNOS, p-STAT3, and p-Akt. In summary, G-CSF was found to have neuroprotective effects and save striatal cells through activations of survival pathways in the 3NP-induced striatal degeneration model for HD. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUNTINGTON'S chorea
KW - CHOREA
KW - GENETIC disorders
KW - DEMENTIA
KW - 3-Nitropropionic acid
KW - Granulocyte-colony stimulating factor (G-CSF)
KW - Huntington's disease
KW - Neuroprotection
KW - Survival pathways
N1 - Accession Number: 29992666; Lee, Soon-Tae 1,2,3 Park, Jung-Eun 1 Kim, Dong-Hyun 1 Kim, Seungchan 4 Im, Woo-Seok 1 Kang, Lami 1 Jung, Se Hee 5 Kim, Min-Wook 6 Chu, Kon 1,2 Kim, Manho 1,2; Email Address: kimmanho@snu.ac.kr; Affiliation: 1: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea 2: Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, South Korea 3: Program in Public Health Service, Seoul National Hospital, Seoul, South Korea 4: Seoul Science High School, Seoul, South Korea 5: Department of Rehabilitation Medicine, Seoul Metropolitan Boramae Hospital Seoul, South Korea 6: Department of Rehabilitation Medicine, Our Lady of Mercy Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Source Info: Feb2008, Vol. 1194, p130; Subject Term: HUNTINGTON'S chorea; Subject Term: CHOREA; Subject Term: GENETIC disorders; Subject Term: DEMENTIA; Author-Supplied Keyword: 3-Nitropropionic acid; Author-Supplied Keyword: Granulocyte-colony stimulating factor (G-CSF); Author-Supplied Keyword: Huntington's disease; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Survival pathways; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.brainres.2007.11.058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maxim, L. Daniel
AU - Allshouse, John
AU - Fairfax, Richard E.
AU - Lentz, T. J.
AU - Venturin, Dean
AU - Walters, Thomas E.
T1 - Workplace Monitoring of Occupational Exposure to Refractory Ceramic Fiber - A 17-Year Retrospective.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2008/02/15/
VL - 20
IS - 3
M3 - Article
SP - 289
EP - 309
SN - 08958378
AB - This article presents a 17-year (1990-2006) retrospective summary of ongoing studies of occupational exposure to refractory ceramic fiber (RCF) in the United States. Beginning in 1990, RCF producers integrated and harmonized individual workplace monitoring programs to provide data useful for various longitudinal and cross-sectional analyses, benchmarking, and various technical analyses. For 10 of these 17 years, the program has been conducted in partnership with government agencies, first a 5-year (1993-1998) program with the U.S. Environmental Protection Agency and later another 5-year (2002-2006) program with the Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health. This article updates earlier published studies and provides lessons to be learned in the design of industrial hygiene monitoring and control programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Industrial safety
KW - Environmental policy
KW - Work environment
KW - Ceramic fibers
KW - Benchmarking (Management)
KW - Industrial management
KW - Confined spaces (Work environment)
KW - United States
N1 - Accession Number: 30063352; Maxim, L. Daniel 1; Email Address: Postsf@aol.com; Allshouse, John 1; Fairfax, Richard E. 2; Lentz, T. J. 3; Venturin, Dean 4; Walters, Thomas E. 5; Affiliations: 1: Everest Consulting Associates, Cranbury, New Jersey, USA; 2: U.S. Department of Labor, Occupational Safety and Health Administration, Washington, DC, USA; 3: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 4: Unifrax Corp, Niagara Falls, New York, USA; 5: Morgan Insulation, Inc., Erwin, Tennessee, USA; Issue Info: Feb2008, Vol. 20 Issue 3, p289; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Environmental policy; Subject Term: Work environment; Subject Term: Ceramic fibers; Subject Term: Benchmarking (Management); Subject Term: Industrial management; Subject Term: Confined spaces (Work environment); Subject: United States; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 21p; Illustrations: 1 Diagram, 2 Charts, 18 Graphs; Document Type: Article
L3 - 10.1080/08958370701866040
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Wu, John Z.
AU - An, Kai-Nan
AU - Cutlip, Robert G.
AU - Krajnak, Kristine
AU - Welcome, Daniel
AU - Dong, Ren G.
T1 - Analysis of musculoskeletal loading in an index finger during tapping
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2008/02/15/
VL - 41
IS - 3
M3 - Article
SP - 668
EP - 676
SN - 00219290
AB - Abstract: Since musculoskeletal disorders of the upper extremities are believed to be associated with repetitive excessive muscle force production in the hands, understanding the time-dependent muscle forces during key tapping is essential for exploring the mechanisms of disease initiation and development. In the current study, we have simulated the time-dependent dynamic loading in the muscle/tendons in an index finger during tapping. The index finger model is developed using a commercial software package AnyBody, and it contains seven muscle/tendons that connect the three phalangeal finger sections. Our simulations indicate that the ratios of the maximal forces in flexor digitorum superficialis (FS) and flexor digitorum profundus (FP) tendons to the maximal force at the fingertip are 0.95 and 2.9, respectively, which agree well with recently published experimental data. The time sequence of the finger muscle activation predicted in the current study is consistent with the EMG data in the literature. The proposed model will be useful for bioengineers and ergonomic designers to improve keyboard design minimizing musculoskeletal loadings in the fingers. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCULOSKELETAL system
KW - FINGERS
KW - MUSCLES
KW - TENDONS
KW - Index finger
KW - Muscle force
KW - Muscle–tendon excursion
KW - Simulations
KW - Tapping
N1 - Accession Number: 29402626; Wu, John Z. 1; Email Address: jwu@cdc.gov An, Kai-Nan 2 Cutlip, Robert G. 1 Krajnak, Kristine 1 Welcome, Daniel 1 Dong, Ren G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA 2: Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Source Info: Feb2008, Vol. 41 Issue 3, p668; Subject Term: MUSCULOSKELETAL system; Subject Term: FINGERS; Subject Term: MUSCLES; Subject Term: TENDONS; Author-Supplied Keyword: Index finger; Author-Supplied Keyword: Muscle force; Author-Supplied Keyword: Muscle–tendon excursion; Author-Supplied Keyword: Simulations; Author-Supplied Keyword: Tapping; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jbiomech.2007.09.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dickerson, Clark H.
AU - Saha, Subrata
AU - Hotchkiss, Charlotte E.
T1 - Relationships Between Densitometric and Morphological Parameters as Measured by Peripheral Computed Tomography and the Compressive Behavior of Lumbar Vertebral Bodies From Macaques (Macaca fascicularis).
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2008/02/15/
VL - 33
IS - 4
M3 - Article
SP - 366
EP - 372
SN - 03622436
AB - The article discusses a study which compared the measured maximum compressive force and stress of lumbar vertebral bodies from cynomolgus monkeys with peripheral quantitative computed tomography (PQCT) derived densitometric and morphologic vertebral parameters. Several PQCT guidelines correlated with mechanical behavior. The trabecular and the cortical\subcortical area had the strongest associations with the maximum load and stress magnitudes.
KW - MACAQUES
KW - VERTEBRATES
KW - STRESS (Physiology)
KW - TOMOGRAPHY
KW - HIGHER nervous activity
KW - PERIPHERAL nervous system
KW - mechanical tolerance
KW - non-invasive bone assessment
KW - tissue strength
KW - vertebrae
N1 - Accession Number: 31217722; Dickerson, Clark H. 1; Email Address: cdickers@uwaterloo.ca Saha, Subrata 2 Hotchkiss, Charlotte E. 3; Affiliation: 1: Faculty of Applied Health Sciences, Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada 2: Department of Orthopedic Surgery and Rehabilitation Medicine, SUNY Downstate-Medical Center, Brooklyn, NY 3: National Center for Toxicological Research, The Food and Drug Administration, The Bionetics Corporation, Jefferson, AR; Source Info: 2/15/2008, Vol. 33 Issue 4, p366; Subject Term: MACAQUES; Subject Term: VERTEBRATES; Subject Term: STRESS (Physiology); Subject Term: TOMOGRAPHY; Subject Term: HIGHER nervous activity; Subject Term: PERIPHERAL nervous system; Author-Supplied Keyword: mechanical tolerance; Author-Supplied Keyword: non-invasive bone assessment; Author-Supplied Keyword: tissue strength; Author-Supplied Keyword: vertebrae; Number of Pages: 7p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Jacobson-Kram, David
AU - Mattison, Donald
AU - Shelby, Michael
AU - Slikker, William
AU - Tice, Raymond
AU - Witt, Kristine
T1 - Methylphenidate and chromosome damage
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2008/02/18/
VL - 260
IS - 1/2
M3 - Letter
SP - 216
EP - 218
SN - 03043835
N1 - Accession Number: 28610729; Jacobson-Kram, David 1; Email Address: david.jacobsonkram@fda.hhs.gov Mattison, Donald 2 Shelby, Michael 3 Slikker, William 4 Tice, Raymond 3 Witt, Kristine 3; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research, FDA, Silver Spring, MD 20993, USA Tel.: +1 301 796 0175; fax: +1 301 796 9856. 2: National Institute for Child Health and Development, NIH, Rockville, MD 20892, USA 3: National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA 4: National Center for Toxicological Research, FDA, Jefferson, AK 72079, USA; Source Info: Feb2008, Vol. 260 Issue 1/2, p216; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.canlet.2007.10.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=28610729&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zou, X.
AU - Sadovova, N.
AU - Patterson, T.A.
AU - Divine, R.L.
AU - Hotchkiss, C.E.
AU - Ali, S.F.
AU - Hanig, J.P.
AU - Paule, M.G.
AU - Slikker, W.
AU - Wang, C.
T1 - The effects of l-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex
JO - Neuroscience
JF - Neuroscience
Y1 - 2008/02/19/
VL - 151
IS - 4
M3 - Article
SP - 1053
EP - 1065
SN - 03064522
AB - Abstract: The anesthetic gas nitrous oxide (N2O) and the volatile anesthetic isoflurane (ISO) are commonly used in surgical procedures for human infants and in veterinary and laboratory animal practice to produce loss of consciousness and analgesia. Recent reports indicate that exposure of the developing brain to general anesthetics that block N-methyl-D-aspartate (NMDA) glutamate receptors or potentiate GABA(A) receptors can trigger widespread apoptotic neurodegeneration. In the present study, the question arises whether a relatively low dose of ISO alone or its combination with N2O entails significant risk of inducing enhanced apoptosis. In addition, the role of l-carnitine to attenuate these effects was also examined. Postnatal day 7 (PND-7) rat pups were exposed to N2O (75%) or a low dose of ISO (0.55%) alone, or N2O plus ISO for 2, 4, 6 or 8 h with or without l-carnitine. The neurotoxic effects were evaluated 6 h after completion of anesthetic administration. No significant neurotoxic effects were observed for the animals exposed to N2O or ISO alone. However, enhanced apoptotic cell death was apparent when N2O was combined with ISO at exposure durations of 6 h or more. Co-administration of l-carnitine (300 or 500 mg/kg, i.p.) effectively protected neurons from the anesthetic-induced damage. These data indicate that 6 h or more of inhaled anesthetic exposure consisting of a combination of N2O and ISO results in enhanced neuronal apoptosis, and l-carnitine effectively blocks the neuronal apoptosis caused by inhalation anesthetics in the developing rat brain. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANESTHETICS
KW - CELL death
KW - SERUM
KW - BLOOD proteins
KW - α-2
KW - α-2,8-linked sialic acid neural cell adhesion molecule ( PSA-NCAM )
KW - 8-linked sialic acid neural cell adhesion molecule ( PSA-NCAM )
KW - apoptosis
KW - bovine serum albumin ( BSA )
KW - caspase-3
KW - isoflurane
KW - isoflurane ( ISO )
KW - N-methyl-D-aspartate ( NMDA )
KW - neuronal protection
KW - nitrous oxide
KW - nitrous oxide ( N2O )
KW - postnatal day ( PND )
KW - reactive oxygen species ( ROS )
N1 - Accession Number: 29961427; Zou, X. 1 Sadovova, N. 2 Patterson, T.A. 1 Divine, R.L. 2 Hotchkiss, C.E. 3 Ali, S.F. 1 Hanig, J.P. 4 Paule, M.G. 1 Slikker, W. 1 Wang, C. 1; Email Address: Cheng.wang@fda.hhs.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Toxicologic Pathology Associates, Jefferson, AR 72079, USA 3: Bionetics Corporation, Jefferson, AR 72079, USA 4: Center for Drug Evaluation and Research/U.S. Food and Drug Administration, Silver Spring, MD 20993, USA; Source Info: Feb2008, Vol. 151 Issue 4, p1053; Subject Term: ANESTHETICS; Subject Term: CELL death; Subject Term: SERUM; Subject Term: BLOOD proteins; Author-Supplied Keyword: α-2; Author-Supplied Keyword: α-2,8-linked sialic acid neural cell adhesion molecule ( PSA-NCAM ); Author-Supplied Keyword: 8-linked sialic acid neural cell adhesion molecule ( PSA-NCAM ); Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: bovine serum albumin ( BSA ); Author-Supplied Keyword: caspase-3; Author-Supplied Keyword: isoflurane; Author-Supplied Keyword: isoflurane ( ISO ); Author-Supplied Keyword: N-methyl-D-aspartate ( NMDA ); Author-Supplied Keyword: neuronal protection; Author-Supplied Keyword: nitrous oxide; Author-Supplied Keyword: nitrous oxide ( N2O ); Author-Supplied Keyword: postnatal day ( PND ); Author-Supplied Keyword: reactive oxygen species ( ROS ); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.neuroscience.2007.12.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pixu Li
AU - Evans, Cory D.
AU - Yongzhong Wu
AU - Bin Cao
AU - Hamel, Ernest
AU - Joullië, Madeleine M.
T1 - Evolution of the Total Syntheses of Ustiloxin Natural Products and Their Analogues.
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
Y1 - 2008/02/20/
VL - 130
IS - 7
M3 - Article
SP - 2351
EP - 2364
SN - 00027863
AB - Ustiloxins A-F are antimitotic heterodetic cyclopeptides containing a 13-membered cyclic core structure with a synthetically challenging chiral tertiary alkyl-aryl ether linkage. The first total synthesis of ustiloxin D was achieved in 31 linear steps using an SNAr reaction. An NOE study of this synthetic product showed that ustiloxin D existed as a single atropisomer. Subsequently, highly concise and convergent syntheses of ustiloxins D and F were developed by utilizing a newly discovered ethynyl aziridine ring-opening reaction in a longest linear sequence of 15 steps. The approach was further optimized to achieve a better macrolactamization strategy. Ustiloxins D, F, and eight analogues (14-MeO-ustiloxin D, four analogues with different amino acid residues at the C-6 position, and three (9R,10S)-epi-ustiloxin analogues) were prepared via the second-generation route. Evaluation of these compounds as inhibitors of tubulin polymerization demonstrated that variation at the C-6 position is tolerated to a certain extent. In contrast, the S configuration of the C-9 methylamino group and a free phenolic hydroxyl group are essential for inhibition of tubulin polymerization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Chemical Society is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NATURAL products
KW - ANTIMITOTIC agents
KW - CHIRALITY
KW - AZIRIDINES
KW - AMINO acids
N1 - Accession Number: 31215079; Pixu Li 1,2 Evans, Cory D. 1,3 Yongzhong Wu 1 Bin Cao 1,4 Hamel, Ernest 5 Joullië, Madeleine M. 1; Email Address: mjoullie@sas.uperin.edu; Affiliation: 1: Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 2: Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965 3: U.S. Food and Drug Administration, CVM/ONADE/DMT HFV-142, 7500 Standish Place, Rockville, MD 20855 4: Sanofi-Aventis, 1041 Route 202-206, Bridgewater, NJ 08807 5: Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702; Source Info: 2/20/2008, Vol. 130 Issue 7, p2351; Subject Term: NATURAL products; Subject Term: ANTIMITOTIC agents; Subject Term: CHIRALITY; Subject Term: AZIRIDINES; Subject Term: AMINO acids; Number of Pages: 14p; Illustrations: 22 Diagrams, 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Shen
AU - Hirsch, Dianne S.
AU - Sasiela, Christy A.
AU - Wen Jin Wu
T1 - Cdc42 Regulates E-cadherin Ubiquitination and Degradation through an Epidermal Growth Factor Receptor to Src-mediated Pathway.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008/02/22/
VL - 283
IS - 8
M3 - Article
SP - 5127
EP - 5137
SN - 00219258
AB - E-cadherins play an essential role in maintaining epithelial polarity by forming Ca2+-dependent adherens junctions between epithelial cells. Here, we report that Ca2+ depletion induces E-cadherin ubiquitination and lysosomal degradation and that Cdc42 plays an important role in regulating this process. We demonstrate that Ca2+ depletion induces activation of Cdc42. This in turn up-regulates epidermal growth factor receptor (EGFR) signaling to mediate Src activation, leading to E-cadherin ubiquitination and lysosomal degradation. Silencing Cdc42 blocks activation of EGFR and Src induced by Ca2+ depletion, resulting in a reduction in E-cadherin degradation. The role of Cdc42 in regulating E-cadherin ubiquitination and degradation is underscored by the fact that constitutively active Cdc42(F28L) increases the activity of EGFR and Src and significantly enhances E-cadherin ubiquitination and lysosomal degradation. Furthermore, we found that GTP-dependent binding of Cdc42 to E-cadherin is critical for Cdc42 to induce the dissolution of adherens junctions. Our data support a model that activation of Cdc42 contributes to mesenchyme-like phenotype by targeting of E-cadherin for lysosomal degradation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMAL growth factor
KW - CADHERINS
KW - UBIQUITIN
KW - EPITHELIAL cells
KW - LYSOSOMES
N1 - Accession Number: 31387077; Yi Shen 1 Hirsch, Dianne S. 1 Sasiela, Christy A. 1 Wen Jin Wu 1; Email Address: wen.wu@fda.hhs.gov; Affiliation: 1: From the Division of MonoclonalAntibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 2/22/2008, Vol. 283 Issue 8, p5127; Subject Term: EPIDERMAL growth factor; Subject Term: CADHERINS; Subject Term: UBIQUITIN; Subject Term: EPITHELIAL cells; Subject Term: LYSOSOMES; Number of Pages: 11p; Illustrations: 9 Graphs; Document Type: Article
L3 - 10.1074/jbc.M703300200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Volpe, Donna A.
AU - Gupta, Abhay
AU - Ciavarella, Anthony B.
AU - Faustino, Patrick J.
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
T1 - Comparison of the stability of split and intact gabapentin tablets
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/02/28/
VL - 350
IS - 1/2
M3 - Article
SP - 65
EP - 69
SN - 03785173
AB - Abstract: The purpose of this study was to determine the stability differences between split and intact gabapentin tablets. Gabapentin tablets from three different manufacturers (G1, G2 and G3) were tested for a period of 9 weeks under long-term (25°C/60% RH) and intermediate stability (30°C/60% RH) storage conditions after storage in closed amber pharmacy dispensing containers. Samples were analyzed for dissolution and potency using validated HPLC methods. Potency test also included the quantitation of gabapentin''s main degradation product. Tablets from all manufacturers and at all time points had potency >90%. At 9 weeks, a statistically significant decrease (p <0.02) in gabapentin potency was observed for the whole and split G2 and G3 tablets under the intermediate storage conditions. At the end of 9 weeks, all samples also showed slightly higher levels of degradation product which was statistically significant (p <0.01) for samples stored under intermediate stability storage conditions and exceeded the proposed USP (PF, 2006) limit for the G3 split and intact tablets. No difference was observed between the potency and dissolution of the intact and the split tablets from the same manufacturer and the three products tested remained stable throughout the study period. The results suggest that splitting of gabapentin tablets did not affect the stability of these particular drug products tested as part of this study when stored under normal storage conditions for a period of up to 9 weeks. However, the results should not be extrapolated to other gabapentin drug products and to other tablet dosage forms. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICINE
KW - PHARMACY
KW - CONTAINERS
KW - DRUGS
KW - Gabapentin
KW - Split-tablet
KW - Stability
N1 - Accession Number: 28801582; Volpe, Donna A. 1 Gupta, Abhay 1 Ciavarella, Anthony B. 1 Faustino, Patrick J. 1 Sayeed, Vilayat A. 2 Khan, Mansoor A. 1; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, Life Science Building 64, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Office of Generic Drugs, Office of Pharmaceutical Science, Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA; Source Info: Feb2008, Vol. 350 Issue 1/2, p65; Subject Term: MEDICINE; Subject Term: PHARMACY; Subject Term: CONTAINERS; Subject Term: DRUGS; Author-Supplied Keyword: Gabapentin; Author-Supplied Keyword: Split-tablet; Author-Supplied Keyword: Stability; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijpharm.2007.08.041
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oliva, Jose L.
AU - Caino51, M. Cecilia
AU - Senderowicz, Adrian M.
AU - Kazanietz, Marcelo G.
T1 - S-Phase-specific Activation of PKCα Induces Senescence in Non-small Cell Lung Cancer Cells.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008/02/29/
VL - 283
IS - 9
M3 - Article
SP - 5466
EP - 5476
SN - 00219258
AB - Protein kinase C (PKC) has been widely implicated in positive and negative control of cell proliferation. We have recently shown that treatment of non-small cell lung cancer (NSCLC) cells with phorbol 12-myristate 13-acetate (PMA) during G1 phase inhibits the progression into S phase, an effect mediated by PKCδ-induced up-regulation of the cell cycle inhibitor p21Cip1). However, PMA treatment in asynchronously growing NSCLC cells leads to accumulation of cells in G2/M. Studies in post-G1 phases revealed that PMA induced an irreversible G2/M cell cycle arrest in NSCLC cells and conferred morphological and biochemical features of senescence, including elevated SA-β-Gal activity and reduced telomerase activity. Remarkably, this effect was phase-specific, as it occurred only when PKC was activated in S, but not in G1, phase. Mechanistic analysis revealed a crucial role for the classical PKCα isozyme as mediator of the G2/M arrest and senescence, as well as for inducing p21Cip1 an obligatory event for conferring the senescence phenotype. In addition to the unappreciated role of PKC isozymes, and specifically PKCα, in senescence, our data introduce the paradigm that discrete PKCs trigger distinctive responses when activated in different phases of the cell cycle via a common mechanism that involves p21Cip1 up-regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN kinase C
KW - LUNGS -- Cancer
KW - CANCER cells
KW - CELL proliferation
KW - ISOENZYMES
KW - CELL cycle
KW - CANCER treatment
N1 - Accession Number: 31300191; Oliva, Jose L. 1,2 Caino51, M. Cecilia Senderowicz, Adrian M. 2 Kazanietz, Marcelo G. 1; Email Address: marcelo@spirit.gcrc.upenn.edu; Affiliation: 1: Department of Pharmacology and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160 2: CDER, Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: 2/29/2008, Vol. 283 Issue 9, p5466; Subject Term: PROTEIN kinase C; Subject Term: LUNGS -- Cancer; Subject Term: CANCER cells; Subject Term: CELL proliferation; Subject Term: ISOENZYMES; Subject Term: CELL cycle; Subject Term: CANCER treatment; Number of Pages: 11p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1074/jbc.M707576200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, Shih-Houng
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Erdely, Aaron D.
AU - Zeidler-Erdely, Patti C.
T1 - Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2008/02/29/
VL - 331
IS - 1/2
M3 - Article
SP - 59
EP - 68
SN - 00221759
AB - Abstract: There is a growing demand for a cost-effective, efficient, and high-throughput method for measuring cytokines. Currently, many studies are using flow cytometric bead-based multiplex assays in the measurement of cytokines. However, limited data are available regarding the performance of these cytometric bead assays versus enzyme-linked immunosorbent assay (ELISA) or correlation with mRNA expression using real time reverse transcriptase-polymerase chain reaction (RT-PCR). In one of our studies, cytometric bead array (CBA) was used to measure inflammatory cytokine protein levels in bronchoalveolar lavage (BAL) samples from mice exposed to welding fume, an inflammatory particulate. The results were then compared to whole lung mRNA levels of the same cytokines measured by real time RT-PCR in the same mouse model. It was found that the trends in cytokine profiles measured via CBA agreed with the whole lung mRNA results. In a separate experiment, we used a rat zymosan infectivity model to induce a pulmonary immunomodulatory response and determined cytokine concentrations in recovered BAL fluid by ELISA and two different types of cytometric bead-based assays, CBA and FlowCytomix (FC). The sample-to-sample correlation was good between ELISA and CBA with correlation coefficient R values of 0.76, 0.66, and 0.92 for rat IFN-γ, TNF-α, and IL-6, respectively. ELISA only correlated significantly with the FC assay for TNF-α with R =0.43. Patterns of cytokine response in our rat model also differed among the assays but overall, the ELISA and CBA yielded similar results. For a method-to-method comparison, we assayed supplied cytokine standards from ELISA kits using both ELISA and CBA to determine the R values and found it to be greater than 0.90 for all the cytokines tested. It was found that the ELISA was more sensitive in the low range of the standard curve while the bead assays were capable of detecting higher protein concentrations, which would allow for direct measurement of concentrated samples. There was a lack of agreement between the absolute protein values for the ELISA and flow cytometric bead-based assays; in most cases, the latter method tended to give higher protein concentrations than ELISA. In conclusion, direct comparisons between absolute protein values did not agree among the assays tested in this study, but patterns of cytokine response generally agreed between ELISA and CBA. In the case of the mouse CBA, a companion measurement is recommended if samples with low concentrations of an analyte are reported and extrapolated below sensitivity or zero. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - CYTOKINES
KW - IMMUNE response -- Regulation
KW - GLYCOPROTEINS
KW - bronchoalveolar lavage ( BAL )
KW - Cytokines
KW - cytometric bead array ( CBA )
KW - ELISA
KW - enzyme-linked immunosorbent assays ( ELISA )
KW - Flow cytometric bead assays
KW - FlowCytomix ( FC )
KW - interferon-γ ( IFN-γ )
KW - interleukin ( IL )
KW - manual metal arc-stainless steel welding fume. ( MMA-SS WF )
KW - monocyte chemoattractant protein-1 ( MCP-1 )
KW - Multiplex immunoassay
KW - Reverse transcriptase-polymerase chain reaction ( RT-PCR )
KW - RT-PCR
KW - tumor necrosis factor-α ( TNF-α )
N1 - Accession Number: 29961904; Young, Shih-Houng; Email Address: syoung@cdc.gov Antonini, James M. 1 Roberts, Jenny R. 1 Erdely, Aaron D. 1 Zeidler-Erdely, Patti C. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States; Source Info: Feb2008, Vol. 331 Issue 1/2, p59; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: CYTOKINES; Subject Term: IMMUNE response -- Regulation; Subject Term: GLYCOPROTEINS; Author-Supplied Keyword: bronchoalveolar lavage ( BAL ); Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: cytometric bead array ( CBA ); Author-Supplied Keyword: ELISA; Author-Supplied Keyword: enzyme-linked immunosorbent assays ( ELISA ); Author-Supplied Keyword: Flow cytometric bead assays; Author-Supplied Keyword: FlowCytomix ( FC ); Author-Supplied Keyword: interferon-γ ( IFN-γ ); Author-Supplied Keyword: interleukin ( IL ); Author-Supplied Keyword: manual metal arc-stainless steel welding fume. ( MMA-SS WF ); Author-Supplied Keyword: monocyte chemoattractant protein-1 ( MCP-1 ); Author-Supplied Keyword: Multiplex immunoassay; Author-Supplied Keyword: Reverse transcriptase-polymerase chain reaction ( RT-PCR ); Author-Supplied Keyword: RT-PCR; Author-Supplied Keyword: tumor necrosis factor-α ( TNF-α ); Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jim.2007.11.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105746387
T1 - Image browsing in slow medical liquid crystal displays.
AU - Liang H
AU - Park S
AU - Gallas BD
AU - Myers KJ
AU - Badano A
Y1 - 2008/03//
N1 - Accession Number: 105746387. Language: English. Entry Date: 20080620. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 9440159.
KW - Computer Terminals
KW - Data Display
KW - Industry
KW - Radiology Information Systems
KW - Algorithms
KW - Color
KW - Diagnostic Imaging
KW - Light
KW - Mammography
KW - Pharmacokinetics
KW - Radiographic Image Enhancement -- Methods
KW - ROC Curve
KW - Time Factors
SP - 370
EP - 382
JO - Academic Radiology
JF - Academic Radiology
JA - ACAD RADIOL
VL - 15
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1076-6332
AD - CDRH/NIBIB Laboratory for the Assessment of Medical Imaging Systems, Division of Imaging and Applied Mathematics, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3113, Silver Spring, MD 20993, USA.
U2 - PMID: 18280935.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105902954
T1 - Partnership for the Americas: dental hygienists and the dental team making a difference globally.
AU - Glines N
Y1 - 2008/03//
N1 - Accession Number: 105902954. Language: English. Entry Date: 20080502. Revision Date: 20150711. Publication Type: Journal Article; pictorial; statistics; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Dental Care. NLM UID: 9885733.
KW - Hospital Ships
KW - International Relations
KW - Military Dentistry
KW - United States Navy
KW - United States Public Health Service
SP - 30
EP - 32
JO - Access
JF - Access
JA - ACCESS
VL - 22
IS - 3
CY - Chicago, Illinois
PB - American Dental Hygienists Association
SN - 1050-0758
AD - U.S. Public Health Service, Pine Ridge Indian Reservation, South Dakota
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baron, Paul A.
AU - Estill, Cherie F.
AU - Deye, Gregory J.
AU - Hein, Misty J.
AU - Beard, Jeremy K.
AU - Larsen, Lloyd D.
AU - Dahlstrom, Gregory E.
T1 - Development of an Aerosol System for Uniformly Depositing Bacillus Anthracis Spore Particles on Surfaces.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2008/03//
VL - 42
IS - 3
M3 - Article
SP - 159
EP - 172
SN - 02786826
AB - After the anthrax incidents in October 2001, several techniques used for sampling surfaces for biological agents were found to be inadequately validated, especially at low surface loadings. Therefore a test chamber was developed to produce sample sets having targeted surface concentrations of dry biological agent simulant. Dry spore aerosols were initially dispersed into the chamber at relatively high air concentrations, and monitored in real time. The concentration decay (due to stirred settling and dilution) was measured and when the targeted air concentration was reached, the sampling surfaces were uncovered and exposed to the settling particles until >99% of the particles had settled. Multiple agar plates were used to estimate the true colony-forming-unit (CFU) surface concentration. The uniformity of surface loadings was limited by random deposition of small numbers of particles on the surfaces (Poisson distribution) and was characterized by how much greater the observed variability was than that predicted by Poisson statistics. The flow-enhanced powder mixture appeared to affect the spores' ability to grow on the agar medium. Three ways of analyzing the agar plates were used to evaluate the effect of spore coatings on viability and to differentiate between number of spore-containing particles and the number of spores. The presence of spore agglomerates re-suspended by various sample handling activities in the chamber further increased the variability of deposited particles. Based on estimated airborne particle concentration, it was possible to predict mean agar plate concentrations within narrow confidence intervals (CI) at low (4.8 CFU, 95% CI 3.5-6.4), medium (20 CFU, 95% CI 17-23), and high (160 CFU, 95% CI 140-190) concentrations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 51167248; Baron, Paul A. 1 Estill, Cherie F. 1 Deye, Gregory J. 1 Hein, Misty J. 1 Beard, Jeremy K. 2 Larsen, Lloyd D. 2 Dahlstrom, Gregory E. 2; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA 2: Dugway Proving Ground, Dugway, Utah, USA; Source Info: Mar2008, Vol. 42 Issue 3, p159; Number of Pages: 14p; Document Type: Article
L3 - 10.1080/02786820801918605
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baron, Paul
AU - Deye, Gregory J.
AU - Martinez, Anthony B.
AU - Jones, Erica N.
AU - Bennett, James S.
T1 - Size Shifts in Measurements of Droplets with the Aerodynamic Particle Sizer and the Aerosizer.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2008/03//
VL - 42
IS - 3
M3 - Article
SP - 201
EP - 209
SN - 02786826
AB - Observations of the size of liquid droplets using the Aerodynamic Particle Sizer (APS) and the Aerosizer indicated that the measured size was significantly different from the aerodynamic diameter as calculated by measuring droplet settling velocity. The size shifts appeared to be caused by droplet distortion in the detector flow field for the Aerosizer. However, for the APS, droplet sizing was further affected by droplet impaction on the upstream side of the focusing nozzle. It is suggested that liquid accumulated in and constricted the nozzle, resulting in a particle velocity increase at the sensor. The size shift can occur with the deposition of <0.5 μ L liquid onto the nozzle; the size shift can occur in 1-10 minutes even at concentrations of 1000 particles/L; and the size shift can disappear after cessation of liquid aerosol sampling. CFD calculations provided information about the amount of velocity increase at the APS sensor for a selected constriction. Both solid and liquid particles are affected by the nozzle constriction, which produces approximately the same percentage size shift throughout the measurement range. The size shifts (Δ) were related to droplet aerodynamic diameter (μ m), viscosity (Pa-s), and surface tension (N/m) by the following empirical equation: Δ = -a diameterb/(surface tensionc × viscositye). The value of b was arbitrarily set to two. The values for a, c, and e for the APS (including both droplet distortion and nozzle constriction) and for the Aerosizer were determined by a regression analysis of the available data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 51167243; Baron, Paul 1 Deye, Gregory J. 1 Martinez, Anthony B. 1 Jones, Erica N. 1 Bennett, James S. 1; Affiliation: 1: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: Mar2008, Vol. 42 Issue 3, p201; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/02786820801958734
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boal, Winifred L.
AU - Leiss, Jack K.
AU - Sousa, Sara
AU - Lyden, Jennifer T.
AU - Jia Li
AU - Jagger, Janine
T1 - The National Study to Prevent Blood Exposure in Paramedics: Exposure Reporting.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/03//
VL - 51
IS - 3
M3 - Article
SP - 213
EP - 222
SN - 02713586
AB - The article evaluates U.S. paramedics' reporting of blood exposure to their employers, by mailing a questionnaire to a national sample of paramedics, which were selected using a two-stage design. Results show that the subjects reported 49 percent of blood exposures and 72 percent of needlestick exposures to their employers. It was found out that those paramedics who believe that exposure reporting will help management prevent future exposures are more common to report these incidences. Findings also reveal that one of the main reasons for under-reporting of the exposures, is due to the paramedics' belief that the exposure do not pose a significant risk.
KW - Industrial hygiene
KW - Industrial safety
KW - Occupational hazards
KW - Allied health personnel
KW - Needlestick injuries
KW - Blood
KW - Medical personnel
KW - Occupational medicine
KW - United States
KW - blood exposure
KW - needlestick
KW - occupational health
KW - paramedics
KW - prehospital
KW - survey
KW - under-reporting
N1 - Accession Number: 31139068; Boal, Winifred L. 1; Email Address: wboal@cdc.gov; Leiss, Jack K. 2; Sousa, Sara 2; Lyden, Jennifer T. 2; Jia Li 2; Jagger, Janine 3; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Statistics and Epidemiology, Health Sciences, Constella Group, LLC, Durham, North Carolina; 3: Department of Internal Medicine, University of Virginia, Charlottesville, Virginia; Issue Info: Mar2008, Vol. 51 Issue 3, p213; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational hazards; Subject Term: Allied health personnel; Subject Term: Needlestick injuries; Subject Term: Blood; Subject Term: Medical personnel; Subject Term: Occupational medicine; Subject: United States; Author-Supplied Keyword: blood exposure; Author-Supplied Keyword: needlestick; Author-Supplied Keyword: occupational health; Author-Supplied Keyword: paramedics; Author-Supplied Keyword: prehospital; Author-Supplied Keyword: survey; Author-Supplied Keyword: under-reporting; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10..1002/ajim.20558
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105898202
T1 - Evaluation of the rationale for concurrent use of N95 filtering facepiece respirators with loose-fitting powered air-purifying respirators during aerosol-generating medical procedures.
AU - Roberge RJ
Y1 - 2008/03//
N1 - Accession Number: 105898202. Language: English. Entry Date: 20080425. Revision Date: 20150819. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Infection Control -- Methods
KW - Occupational Exposure -- Prevention and Control
KW - Respiratory Protective Devices -- Evaluation
KW - Equipment Design
KW - Equipment Safety
SP - 135
EP - 141
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 36
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - The concurrent use of N95 filtering facepiece respirators with powered air-purifying respirators during aerosol-generating medical procedures in patients with severe respiratory pathogens has been promoted as offering additional protection against infectious agents. The purpose of this article is to examine the impact of this additional respiratory equipment upon protection and personal performance. The presumed additive protective effect of an N95 filtering facepiece respirator used concurrently with a powered air-purifying respirator has not been subjected to rigorous scientific investigation. The burden imposed by additional respiratory protective equipment should not be discounted, and the potentially minor contribution to protection may be offset by the negative impact on personal performance. Novel uses of protective equipment occasionally are spawned during crisis situations, but their generalized applicability to healthcare workers should ultimately be evidence-based.
SN - 0196-6553
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA. dtn0@cdc.gov.
U2 - PMID: 18313516.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Riggs, Margaret A.
AU - Maunsell, Fiona P.
AU - Reyes, Leticia
AU - Brown, Mary B.
T1 - Hematogenous infection of Sprague-Dawley rats with Mycoplasma pulmonis: development of a model for maternal and fetal infection
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2008/03//
VL - 198
IS - 3
M3 - Article
SP - 318
EP - 318
SN - 00029378
AB - Objectives: The specific objective of this study was to conduct a dose response experiment with Mycoplasma pulmonis in Sprague-Dawley rats to develop a reproducible animal model of maternal and fetal infection that would provide a versatile mechanism to address the innate fetal immune response during intrauterine infection. Study Design: Pregnant rats were infected intravenously at gestation day 14 with 0 (control), 101, 103, 105, and 107 colony forming units of M pulmonis and necropsied at gestational day 18. Quantitative culture of maternal and fetal tissues as well as histopathologic examination of the placenta were performed. Results: We have characterized a rat model of maternal and fetal infection that can be manipulated by alteration of infectious dose. Colonization of Sprague-Dawley rat dam and fetal tissues by M pulmonis occurred in a dose-dependent manner after intravenous inoculation (P < .001). Placental lesion severity increased with infection dose (P = .0001). The minimum threshold dose required to establish infection of the dam and fetus was at least 103 colony forming units, with consistent colonization of maternal and fetal tissues achieved only with 107 colony forming units. In some instances, rat fetal tissues could be colonized in the absence of concomitant amniotic fluid colonization. Interestingly, there appeared to be a predilection for colonization of the reproductive tissues. Conclusions: In the Sprague-Dawley rat, the infection rate of both the dam and fetus can be controlled by the inoculum dose. Our data support the concept that hematogenous spread of M pulmonis to the rat fetus can occur without amniotic fluid infection and suggest that the fetus itself can potentially seed the amniotic fluid with microorganisms. Importantly, manipulation of both the route of infection as well as infection dose provide a reproducible way to study both maternal and fetal immune response to infection during pregnancy. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOPLASMA diseases
KW - IMMUNE response
KW - PREGNANCY complications
KW - SPRAGUE Dawley rats
KW - INTRAUTERINE contraceptives
KW - animal model
KW - fetal infection
KW - intrauterine infection
N1 - Accession Number: 31156966; Riggs, Margaret A. 1,2; Maunsell, Fiona P. 1; Reyes, Leticia 1; Brown, Mary B. 1; Source Information: Mar2008, Vol. 198 Issue 3, p318; Subject: MYCOPLASMA diseases; Subject: IMMUNE response; Subject: PREGNANCY complications; Subject: SPRAGUE Dawley rats; Subject: INTRAUTERINE contraceptives; Author-Supplied Keyword: animal model; Author-Supplied Keyword: fetal infection; Author-Supplied Keyword: intrauterine infection; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2007.09.042
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Alterman, Toni
AU - Steege, Andrea L.
AU - Li, Jia
AU - Petersen, Martin R.
AU - Muntaner, Carles
T1 - Ethnic, Racial, and Gender Variations in Health Among Farm Operators in the United States
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2008/03//
VL - 18
IS - 3
M3 - Article
SP - 179
EP - 186
SN - 10472797
AB - Purpose: The purpose of this study was to collect baseline prevalence data on the health problems faced by minority, white, and female farm operators. Methods: An occupational health survey of farm operators was conducted by the U.S. Department of Agriculture, National Agricultural Statistics Service between February and August 2000. A stratified random sample of farm operators from 50 U.S. states based on the 1997 Census of Agriculture was selected for telephone interview. Interviews were primarily conducted using a computer assisted telephone instrument system. Results: Population prevalences were calculated for 7137 farm operators. Prevalences were greatest for musculoskeletal discomfort, followed by respiratory problems, hearing loss, and hypertension. Generally, Latino and Asian American operators had lower prevalences for health problems than white non-Latino and white operators, respectively. African-American operators had greater prevalences for hypertension, and osteoarthritis, but lower prevalences for hearing loss, skin problems, heart problems, and cancer than white operators. American Indian or Alaska Native operators had higher prevalences for musculoskeletal problems, skin problems, and hypertension. Conclusions: Prevalences for the different ethnicity and race groups are not the same. Studies that combine racial and ethnic groups, or study only white and non-Latino farm operators may overestimate or underestimate the prevalence of health conditions in the entire farm operator population. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health -- United States
KW - ECONOMIC policy
KW - MEDICAL anthropology
KW - UNITED States
KW - Agricultural Workers
KW - Farm Operators
KW - General Health Questionnaire ( GHQ )
KW - National Agricultural Statistics Service ( NASS )
KW - National Health Interview Survey ( NHIS )
KW - National Institute for Occupational Safety and Health ( NIOSH )
KW - Occupational Health
KW - Surveillance
KW - United States Department of Agriculture ( USDA )
N1 - Accession Number: 29960089; Alterman, Toni 1; Email Address: talterman@cdc.gov Steege, Andrea L. 1 Li, Jia 2 Petersen, Martin R. 1 Muntaner, Carles 3; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 2: Constella Group, LLC, Durham, North Carolina 3: Center for Addictions and Mental Health, University of Toronto, Toronto, Canada; Source Info: Mar2008, Vol. 18 Issue 3, p179; Subject Term: PUBLIC health -- United States; Subject Term: ECONOMIC policy; Subject Term: MEDICAL anthropology; Subject Term: UNITED States; Author-Supplied Keyword: Agricultural Workers; Author-Supplied Keyword: Farm Operators; Author-Supplied Keyword: General Health Questionnaire ( GHQ ); Author-Supplied Keyword: National Agricultural Statistics Service ( NASS ); Author-Supplied Keyword: National Health Interview Survey ( NHIS ); Author-Supplied Keyword: National Institute for Occupational Safety and Health ( NIOSH ); Author-Supplied Keyword: Occupational Health; Author-Supplied Keyword: Surveillance; Author-Supplied Keyword: United States Department of Agriculture ( USDA ); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.annepidem.2007.11.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=29960089&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105907600
T1 - Ethnic, racial, and gender variations in health among farm operators in the United States.
AU - Alterman T
AU - Steege AL
AU - Li J
AU - Petersen MR
AU - Muntaner C
Y1 - 2008/03//
N1 - Accession Number: 105907600. Language: English. Entry Date: 20080509. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Instrumentation: General Health Questionnaire (GHQ). NLM UID: 9100013.
KW - Ethnic Groups
KW - Farmworkers
KW - Health Status -- Evaluation
KW - Sex Factors
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Asians
KW - Blacks
KW - Cardiovascular Diseases
KW - Data Analysis Software
KW - Female
KW - Hearing Disorders
KW - Hispanics
KW - Hypertension
KW - Interviews
KW - Male
KW - Middle Age
KW - Multiple Logistic Regression
KW - Musculoskeletal Diseases
KW - Native Americans
KW - Neoplasms
KW - Occupational Health
KW - Osteoarthritis
KW - Questionnaires
KW - Random Sample
KW - Respiration Disorders
KW - Skin Diseases
KW - Telephone
KW - Whites
KW - Human
SP - 179
EP - 186
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 18
IS - 3
CY - New York, New York
PB - Elsevier Science
AB - PURPOSE: The purpose of this study was to collect baseline prevalence data on the health problems faced by minority, white, and female farm operators. METHODS: An occupational health survey of farm operators was conducted by the U.S. Department of Agriculture, National Agricultural Statistics Service between February and August 2000. A stratified random sample of farm operators from 50 U.S. states based on the 1997 Census of Agriculture was selected for telephone interview. Interviews were primarily conducted using a computer assisted telephone instrument system. RESULTS: Population prevalences were calculated for 7137 farm operators. Prevalences were greatest for musculoskeletal discomfort, followed by respiratory problems, hearing loss, and hypertension. Generally, Latino and Asian American operators had lower prevalences for health problems than white non-Latino and white operators, respectively. African-American operators had greater prevalences for hypertension, and osteoarthritis, but lower prevalences for hearing loss, skin problems, heart problems, and cancer than white operators. American Indian or Alaska Native operators had higher prevalences for musculoskeletal problems, skin problems, and hypertension. CONCLUSIONS: Prevalences for the different ethnicity and race groups are not the same. Studies that combine racial and ethnic groups, or study only white and non-Latino farm operators may overestimate or underestimate the prevalence of health conditions in the entire farm operator population.
SN - 1047-2797
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
U2 - PMID: 18280919.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105907600&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105748225
T1 - Field measurement of diesel particulate matter emissions.
AU - Volkwein JC
AU - Mischler SE
AU - Davies B
AU - Ellis C
Y1 - 2008/03//
N1 - Accession Number: 105748225. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Pollutants, Occupational -- Analysis
KW - Air Pollution -- Analysis
KW - Particulate Matter -- Analysis
KW - Petroleum -- Adverse Effects
KW - Air Pollutants, Occupational -- Adverse Effects
KW - Carbon -- Adverse Effects
KW - Carbon -- Analysis
KW - Environmental Monitoring -- Methods
KW - Environmental Monitoring
KW - Equipment Design -- Standards
KW - Female
KW - Male
KW - Mining
KW - Particulate Matter -- Adverse Effects
KW - Human
SP - 99
EP - 105
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 2
PB - Oxford University Press / USA
SN - 0003-4878
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, Pittsburgh, PA 15236, USA.
U2 - PMID: 18281294.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105748222
T1 - An evaluation of impact wrench vibration emissions and test methods.
AU - McDowell TW
AU - Dong RG
AU - Xu X
AU - Welcome DE
AU - Warren C
Y1 - 2008/03//
N1 - Accession Number: 105748222. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Hand -- Physiology
KW - Occupational Exposure -- Adverse Effects
KW - Vibration -- Adverse Effects
KW - Algorithms
KW - Equipment Design -- Standards
KW - Male
KW - Occupational Exposure
KW - Predictive Value of Tests
KW - Torque
KW - Human
SP - 125
EP - 138
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 2
PB - Oxford University Press / USA
SN - 0003-4878
AD - National Institute for Occupational Safety and Health (NIOSH), NIOSH Health Effects Lab, 1095 Willowdale Road, Morgantown, WV 26505, USA.
U2 - PMID: 18212244.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105748222&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105748221
T1 - Monitoring microbial populations on wide-body commercial passenger aircraft.
AU - McKernan LT
AU - Wallingford KM
AU - Hein MJ
AU - Burge H
AU - Rogers CA
AU - Herrick R
Y1 - 2008/03//
N1 - Accession Number: 105748221. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Microbiology -- Standards
KW - Air Pollution, Indoor -- Adverse Effects
KW - Aircraft
KW - Environmental Monitoring -- Methods
KW - Air Pollution, Indoor -- Analysis
KW - Bacillus
KW - Colony Count, Microbial -- Methods
KW - Female
KW - Gram-Positive Bacteria
KW - Male
KW - Staphylococcus
SP - 139
EP - 149
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 2
PB - Oxford University Press / USA
SN - 0003-4878
AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
U2 - PMID: 18316352.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105748221&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105904973
T1 - SCIP: making complications of surgery the exception rather than the rule.
AU - Clancy CM
Y1 - 2008/03//
N1 - Accession Number: 105904973. Language: English. Entry Date: 20080502. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care; Quality Assurance. NLM UID: 0372403.
KW - Perioperative Care
KW - Postoperative Complications -- Prevention and Control
KW - Quality Improvement
KW - Postoperative Complications -- Economics
SP - 621
EP - 624
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 87
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality, Rockville, MD.
U2 - PMID: 18328282.
DO - 10.1016/j.aorn.2008.02.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105904973&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kong, Yong-Ku
AU - Lowe, Brian D.
AU - Lee, Soo-Jin
AU - Krieg, Edward F.
T1 - Evaluation of handle shapes for screwdriving
JO - Applied Ergonomics
JF - Applied Ergonomics
Y1 - 2008/03//
VL - 39
IS - 2
M3 - Article
SP - 191
EP - 198
SN - 00036870
AB - Abstract: This study investigated the effects of screwdriver handle shape, surface, and workpiece orientation on subjective discomfort, number of screw-tightening rotations, screw-insertion time, axial screwdriving force, and finger contact forces in a screwdriving task. Handles with three longitudinal cross-sectional shapes (circular, hexagonal, triangular), four lateral shapes (cylindrical, double frustum, reversed double frustum, cone), and two surface materials (plastic, rubber coated) were tested. Individual phalangeal segment force distributions indicated how fingers and phalangeal segments were involved in the creation of total finger force (15.0%, 34.6%, 34.5%, and 15.9% for the index, middle, ring, and little fingers; and 45.7%, 22.4%, 12.9%, and 19.0% for the distal, middle, proximal, and metacarpal phalanges, respectively). From this finding, the index and little fingers appeared to contribute mainly in the guiding and balancing of the screwdriver handles, whereas middle and ring fingers played a more prominent role in gripping and turning. Participants preferred circular and hexagonal longitudinal-shaped and double frustum and cone lateral-shaped handles over the triangular longitudinal-shaped handles, and cylindrical and reversed double frustum lateral-shaped handles. Circular, cylindrical, and double frustum handles exhibited the least total finger force associated with screw insertion. In terms of combinations of longitudinal and lateral shapes, circular with double frustum handles were associated with less discomfort and total finger force. [Copyright &y& Elsevier]
AB - Copyright of Applied Ergonomics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FINGERS
KW - SCREWDRIVERS
KW - TOOLS
KW - PERMUTATIONS
KW - Finger/phalange force
KW - Handle surface
KW - Screwdriver handle
KW - Screwdriving
N1 - Accession Number: 27941791; Kong, Yong-Ku 1 Lowe, Brian D. 2; Email Address: bfl4@cdc.gov Lee, Soo-Jin 3 Krieg, Edward F. 2; Affiliation: 1: Department of Systems Management Engineering, Sungkyunkwan University, Suwon, Republic of Korea 2: National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226, USA 3: The College of Medicine, Hanyang University, Seoul, Republic of Korea; Source Info: Mar2008, Vol. 39 Issue 2, p191; Subject Term: FINGERS; Subject Term: SCREWDRIVERS; Subject Term: TOOLS; Subject Term: PERMUTATIONS; Author-Supplied Keyword: Finger/phalange force; Author-Supplied Keyword: Handle surface; Author-Supplied Keyword: Screwdriver handle; Author-Supplied Keyword: Screwdriving; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 444130 Hardware Stores; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.apergo.2007.05.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27941791&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - King, Anna
T1 - KEEPING A SAFE DISTANCE: Individualism and the Less Punitive Public.
JO - British Journal of Criminology
JF - British Journal of Criminology
Y1 - 2008/03//
VL - 48
IS - 2
M3 - Article
SP - 190
EP - 208
SN - 00070955
AB - This article will address individual differences in punitiveness or `get tough' attitudes towards lawbreakers, but will do so by looking in depth at the nature of worldviews that have been identified as decidedly forgiving. The aim is to generate new hypotheses through a grounded narrative analysis regarding a dimension of public sensibilities towards crime— leniency— about which we know very little. I conclude that social identity is an important aspect of merciful worldviews, and that a precondition of a forgiving orientation may be a focus on individual agency. This analysis is supported by quantitative tests of new hypotheses to emerge. This article contributes to the more complex picture of differentiated public opinion to crime and criminal justice that has emerged recently in the literature. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Criminology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDIVIDUAL differences
KW - CRIME
KW - CRIMINAL justice administration
KW - MERCY
KW - FORGIVENESS
KW - GROUP identity
KW - INDIVIDUALISM
KW - CRIMINOLOGY
N1 - Accession Number: 31387277; King, Anna 1,2; Email Address: aking@ifh.rutgers.edu; Affiliation: 1: Keele University, Centre for Criminological Research, Staffordshire, UK 2: Rutgers University, Center for Mental Health Services and Criminal Justice Research, NJ; Source Info: Mar2008, Vol. 48 Issue 2, p190; Subject Term: INDIVIDUAL differences; Subject Term: CRIME; Subject Term: CRIMINAL justice administration; Subject Term: MERCY; Subject Term: FORGIVENESS; Subject Term: GROUP identity; Subject Term: INDIVIDUALISM; Subject Term: CRIMINOLOGY; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 19p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1093/bjc/azm069
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsang, Raymond S. W.
AU - Chao Ming Tsai
AU - Henderson, Averil M.
AU - Tyler, Shaun
AU - Law, Dennis K. S.
AU - Zollinger, Wendell
AU - Jamieson, Frances
T1 - Immunochemical studies and genetic background of two Neisseria meningitidis isolates expressing unusual capsule polysaccharide antigens with specificities of both serogroup Y and W135.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2008/03//
VL - 54
IS - 3
M3 - Article
SP - 229
EP - 234
PB - Canadian Science Publishing
SN - 00084166
AB - We described 2 unusual Neisseria meningitidis strains isolated from epidemiologically unrelated invasive meningococcal disease cases in Ontario, Canada. Both isolates have features typical of serogroup Y N. meningitidis: are of serotype 2c, are of the multi-locus sequence types typical of the serogroup Y strains in Canada, and are genotyped as serogroup Y based on a previously described PCR-ELISA method that detects the serogroup-Y-specific siaD gene. However, both strains were poly-agglutinable in both anti-Y and anti-W135 antisera. Further studies on 1 of these 2 isolates showed the presence of glucose and galactose as well as sialic acids in its purified capsular polysaccharide, suggesting the presence of both serogroup Y and serogroup W135 polysaccharides. Rabbit antisera produced to this strain contained antibodies to both purified serogroup Y and serogroup W135 capsular polysaccharides. Absorption experiments with either serogroup Y or serogroup W135 bacteria confirmed the presence of antibodies to these 2 different polysaccharides. DNA sequencing of the cps operon from both isolates revealed a siaD gene with 99.7% homology to the published siaD sequence from a serogroup Y strain but with 3 point mutations that all resulted in amino acid changes. How these strains may affect results of routine surveillance, PCR diagnosis, and immuno-protection by vaccination are discussed. (English) [ABSTRACT FROM AUTHOR]
AB - Nous décrivons 2 souches extraordinaires de Neisseria meningitidis isolées de 2 cas de maladie à méningocoques, non reliés d’un point de vue épidémiologique, en Ontario, Canada. Les 2 isolats possèdent les caractéristiques typiques du groupe Y de N. meningitidis : appartenance au type sérologique 2c, présence de séquences multi-locus typiques des souches du groupe sérologique Y au Canada, et appartenance génotypique au groupe sérologique Y par la détection du gène siaD spécifique au groupe sérologique Y à l’aide d’une méthode de PCR-ELISA précédemment décrite. Cependant, les 2 souches pouvaient être agglutinées tant par un antisérum anti-Y qu’avec un antisérum anti-W135. Des études additionnelles réalisées sur un de ces 2 isolats ont révélé la présence de glucose et de galactose, de même que d’acides sialiques, dans les polysaccharides capsulaires purifiés, suggérant la présence de polysaccharides des 2 groupes sérologiques Y et W135. Des antisérums de lapin produits avec cette souche contenaient des anticorps reconnaissant les polysaccharides capsulaires purifiés des groupes sérologiques Y et W135. Des expériences d’absorption réalisées avec des bactéries des groupes sérologiques Y ou W135 ont confirmé la présence d’anticorps dirigés contre ces 2 polysaccharides différents. Le séquençage de l’ADN de l’opéron cps des 2 isolats a révélé la présence d’un gène siaD possédant 99,7 % d’homologie avec la séquence publiée de siaD d’un groupe sérologique Y, mais comportant 3 mutations ponctuelles résultant toutes en un changement d’acide aminé. Nous discutons de la façon dont ces souches peuvent affecter les résultats des contrôles de routine, du diagnostic par PCR et de l’immuno-protection par la vaccination. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - NEISSERIA
KW - MENINGITIS
KW - IMMUNE serums
KW - GLUCOSE
KW - GALACTOSE
KW - ENZYME-linked immunosorbent assay
KW - ONTARIO
KW - CANADA
KW - N. meningitidis
KW - serogroup Y
KW - W135
KW - groupe sérologique Y
N1 - Accession Number: 31568337; Tsang, Raymond S. W. 1; Email Address: raymond_tsang@phac-aspc.gc.ca Chao Ming Tsai 2 Henderson, Averil M. 1 Tyler, Shaun 3 Law, Dennis K. S. 1 Zollinger, Wendell 4 Jamieson, Frances 5; Affiliation: 1: Laboratory for Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada 2: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: DNA Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada 4: Walter Reed Army Institute of Research, Department of Bacterial Diseases, Silver Spring, MD 20910, USA 5: Ontario Public Health Laboratory, Ministry of Health and Long Term Care, 81 Resources Road, Etobicoke, Toronto, ON M9P 3T1, Canada; Source Info: Mar2008, Vol. 54 Issue 3, p229; Subject Term: NEISSERIA meningitidis; Subject Term: NEISSERIA; Subject Term: MENINGITIS; Subject Term: IMMUNE serums; Subject Term: GLUCOSE; Subject Term: GALACTOSE; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: ONTARIO; Subject Term: CANADA; Author-Supplied Keyword: N. meningitidis; Author-Supplied Keyword: serogroup Y; Author-Supplied Keyword: W135; Author-Supplied Keyword: groupe sérologique Y; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1139/W07-132
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trinidad, Susan B.
AU - Fryer-Edwards, Kelly
AU - Crest, Anthony
AU - Kyler, Penny
AU - Lloyd-Puryear, Michele A.
AU - Burke, Wylie
T1 - Educational Needs in Genetic Medicine: Primary Care Perspectives.
JO - Community Genetics
JF - Community Genetics
Y1 - 2008/03//
VL - 11
IS - 3
M3 - Article
SP - 160
EP - 165
SN - 14222795
AB - Background/Aims: This study was performed to identify primary care physicians’ (PCPs) attitudes toward genetic medicine and their perceived needs for education in this area. Methods: Semistructured telephone interviews with 24 PCPs in the northwestern United States. Results: PCPs are interested in learning more about who should receive genetic testing and what tests are available. Training in counseling and risk communication is desired, as are ‘just-in-time’ resources to guide clinical decisions. Conclusions: PCPs are eager to learn about genetic medicine; however, their priorities may differ in emphasis from those put forward by genetics experts. Future educational efforts would do well to build on PCPs’ prior knowledge base, highlight the clinical relevance of genetic medicine to primary care practice, and emphasize ‘red flags’: cues to alert PCPs to a potential genetic contribution. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATTITUDE (Psychology)
KW - MEDICAL genetics
KW - MEDICAL education
KW - PHYSICIANS (General practice)
KW - PRIMARY care (Medicine)
KW - UNITED States
KW - Attitudes
KW - Genetics education
KW - Primary care
N1 - Accession Number: 31474163; Trinidad, Susan B. 1; Email Address: sbtrini@u.washington.edu Fryer-Edwards, Kelly 1,2 Crest, Anthony 2 Kyler, Penny 3 Lloyd-Puryear, Michele A. 3 Burke, Wylie 1,2; Affiliation: 1: Department of Medical History and Ethics, University of Washington, Seattle, Wash. USA 2: Institute for Public Health Genetics, University of Washington, Seattle, Wash. USA 3: Health Resources and Services Administration, Department of Health and Human Services, Washington, D.C. , USA; Source Info: 2008, Vol. 11 Issue 3, p160; Subject Term: ATTITUDE (Psychology); Subject Term: MEDICAL genetics; Subject Term: MEDICAL education; Subject Term: PHYSICIANS (General practice); Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Author-Supplied Keyword: Attitudes; Author-Supplied Keyword: Genetics education; Author-Supplied Keyword: Primary care; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1159/000113878
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chin Feman, Siu Ping
AU - Nguyen, Long T.
AU - Quilty, Mary T.
AU - Kerr, Catherine E.
AU - Nam, Bong Hyun
AU - Conboy, Lisa A.
AU - Singer, Joyce P.
AU - Park, Min
AU - Lembo, Anthony J.
AU - Kaptchuk, Ted J.
AU - Davis, Roger B.
T1 - Effectiveness of recruitment in clinical trials: An analysis of methods used in a trial for irritable bowel syndrome patients
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
Y1 - 2008/03//
VL - 29
IS - 2
M3 - Article
SP - 241
EP - 251
SN - 15517144
AB - Abstract: A successful clinical trial is dependent on recruitment. Between December 2003 and February 2006, our team successfully enrolled 289 participants in a large, single-center, randomized placebo-controlled trial (RCT) studying the impact of the patient-doctor relationship and acupuncture on irritable bowel syndrome (IBS) patients. This paper reports on the effectiveness of standard recruitment methods such as physician referral, newspaper advertisements, fliers, audio and video media (radio and television commercials) as well as relatively new methods not previously extensively reported on such as internet ads, ads in mass-transit vehicles and movie theater previews. We also report the fraction of cost each method consumed and fraction of recruitment each method generated. Our cost per call from potential participants varied from $3–$103 and cost per enrollment participant varied from $12–$584. Using a novel metric, the efficacy index, we found that physician referrals and flyers were the most effective recruitment method in our trial. Despite some methods being more efficient than others, all methods contributed to the successful recruitment. The iterative use of the efficacy index during a recruitment campaign may be helpful to calibrate and focus on the most effective recruitment methods. [Copyright &y& Elsevier]
AB - Copyright of Contemporary Clinical Trials is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATIENTS
KW - PERSONS
KW - PATIENT education
KW - PATIENTS -- Legal status, laws, etc.
KW - Acupuncture
KW - Irritable bowel syndrome
KW - Patient–physician relationship
KW - Randomized controlled trials
KW - Recruitment
N1 - Accession Number: 29962051; Chin Feman, Siu Ping 1 Nguyen, Long T. 1 Quilty, Mary T. 1 Kerr, Catherine E. 1 Nam, Bong Hyun 2 Conboy, Lisa A. 1,3 Singer, Joyce P. 1 Park, Min 1 Lembo, Anthony J. 4 Kaptchuk, Ted J. 1,3; Email Address: ted_kaptchuk@hms.harvard.edu Davis, Roger B. 1,3; Affiliation: 1: Osher Institute, Harvard Medical School, Boston, United States 2: Department of Clinical Trials and Biostatistics, Korea Food and Drug Administration, Seoul, Republic of Korea 3: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, United States 4: Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, United States; Source Info: Mar2008, Vol. 29 Issue 2, p241; Subject Term: PATIENTS; Subject Term: PERSONS; Subject Term: PATIENT education; Subject Term: PATIENTS -- Legal status, laws, etc.; Author-Supplied Keyword: Acupuncture; Author-Supplied Keyword: Irritable bowel syndrome; Author-Supplied Keyword: Patient–physician relationship; Author-Supplied Keyword: Randomized controlled trials; Author-Supplied Keyword: Recruitment; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.cct.2007.08.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105722549
T1 - Bronchiolitis obliterans in workers exposed to flavoring chemicals.
AU - Kanwal R
Y1 - 2008/03//2008 Mar
N1 - Accession Number: 105722549. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; pictorial; review. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503765.
KW - Bronchiolitis -- Diagnosis
KW - Occupational Exposure -- Prevention and Control
KW - Food Additives
KW - Food Hypersensitivity -- Diagnosis
KW - Lung Diseases -- Diagnosis
KW - Microwaves
KW - Tomography, X-Ray Computed -- Methods
SP - 141
EP - 146
JO - Current Opinion in Pulmonary Medicine
JF - Current Opinion in Pulmonary Medicine
JA - CURR OPIN PULM MED
VL - 14
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE OF REVIEW: Medical and environmental surveys at microwave popcorn plants and flavoring production plants have revealed a risk for bronchiolitis obliterans in workers exposed to flavoring chemicals. Workers in other food industries may also be at risk. This review summarizes the available information on disease characteristics and natural history and provides information on workplace characteristics associated with disease development. RECENT FINDINGS: Investigations carried out in flavoring plants in California have identified severely affected current and former workers in four plants. Affected former workers have also been identified at a plant in the Netherlands that manufactured diacetyl, a predominant chemical in butter flavorings which has been implicated as a causal agent for lung disease in microwave popcorn workers. SUMMARY: Workers who manufacture or use flavorings can be subjected to repeated intense exposures to flavoring chemicals. Affected workers can progress to severe fixed airways obstruction in as little as 7 months. Since medical treatment is generally ineffective, early identification of affected workers and removal from further exposure, along with control of exposures to protect coworkers, are essential to minimize this hazard.
SN - 1070-5287
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
U2 - PMID: 18303424.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Troy, Douglas A.
AU - Carson, Anne
AU - Vanderbeek, Jean
AU - Hutton, Anne
T1 - Enhancing community-based disaster preparedness with information technology.
JO - Disasters
JF - Disasters
Y1 - 2008/03//
VL - 32
IS - 1
M3 - Article
SP - 149
EP - 165
PB - Wiley-Blackwell
SN - 03613666
AB - A critical component of community-based disaster preparedness (CBDP) is a local resource database of suppliers providing physical, information and human resources for use in disaster response. Maintenance of such a database can become a collaborative responsibility among community-based non-governmental organisations (NGOs) and public and private community organisations. In addition to mobilising resources, this process raises awareness within the community and aids in assessing local knowledge and resources. This paper presents the results of a pilot study on implementing a community-based resource database through collaboration with local American Red Cross chapters and public and private community organisations. The design of the resource database is described. The resource database is accessible via the internet and offline using laptops and handheld Personal Digital Assistants. The study concludes that CBDP is strengthened through a combination of appropriate information technology and collaborative relationships between NGOs and community-based organisations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Disasters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMERGENCY management
KW - INFORMATION technology
KW - HUMAN capital
KW - DATABASES
KW - NONGOVERNMENTAL organizations
KW - COMMUNITY organization
KW - INTERNET
KW - POCKET computers
KW - community-based disaster preparedness (CBDP)
KW - emergency preparedness
KW - information technology
KW - non-governmental organisations (NGOs)
KW - AMERICAN Red Cross
N1 - Accession Number: 28530623; Troy, Douglas A. 1; Email Address: troyda@muohio.edu Carson, Anne 2 Vanderbeek, Jean 2 Hutton, Anne 3; Affiliation: 1: Professor and Chair, Computer Science and Systems Analysis Department, Miami University, Oxford, OH, US 2: Associate Professor, Nursing Department, Miami University, Oxford, OH, US 3: Emergency Management Analyst TAIC (Technology Associations International Corporation) Contract Staff, US Department of Health and Human Services, Administration for Children and Families, Office of Human Services Emergency Preparedness and Response, US.; Source Info: Mar2008, Vol. 32 Issue 1, p149; Subject Term: EMERGENCY management; Subject Term: INFORMATION technology; Subject Term: HUMAN capital; Subject Term: DATABASES; Subject Term: NONGOVERNMENTAL organizations; Subject Term: COMMUNITY organization; Subject Term: INTERNET; Subject Term: POCKET computers; Author-Supplied Keyword: community-based disaster preparedness (CBDP); Author-Supplied Keyword: emergency preparedness; Author-Supplied Keyword: information technology; Author-Supplied Keyword: non-governmental organisations (NGOs); Company/Entity: AMERICAN Red Cross; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 517110 Wired Telecommunications Carriers; NAICS/Industry Codes: 519130 Internet Publishing and Broadcasting and Web Search Portals; Number of Pages: 17p; Illustrations: 8 Black and White Photographs, 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1467-7717.2007.01032.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zaidi, Mussaret B.
AU - Calva, Juan Jose
AU - Estrada-Garcia, Maria Teresa
AU - Leon, Veronica
AU - Vazquez, Gabriela
AU - Figueroa, Gloria
AU - Lopez, Estela
AU - Contreras, Jesus
AU - Abbott, Jason
AU - Shaohua Zhao
AU - McDermott, Patrick
AU - Tollefson, Linda
T1 - Integrated Food Chain Surveillance System for Salmonella spp. in Mexico.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/03//
VL - 14
IS - 3
M3 - Article
SP - 429
EP - 435
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Few developing countries have foodborne pathogen surveillance systems, and none of these integrates data from humans, food, and animals. We describe the implementation of a 4-state, integrated food chain surveillance system (IFCS) for Salmonella spp. in Mexico. Significant findings were 1) high rates of meat contamination (21.3%-36.4%), 2) high rates of ceftriaxone-resistant S. Typhimurium in chicken, ill humans, and swine (77.3%, 66.3%, and 40.4% of S. Typhimurium isolates, respectively), and 3) the emergence of ciprofloxacin resistance in S. Heidelberg (10.4%) and S. Typhimurium (1.7%) from swine. A strong association between Salmonella spp. contamination in beef and asymptomatic Salmonella spp. infection was only observed in the state with the lowest poverty level (Pearson r = 0.91, p<0.001). Pulsed-field gel electrophoresis analysis of 311 S. Typhimurium isolates showed 14 clusters with 102 human, retail meat, and food-animal isolates with indistinguishable patterns. An IFCS is technically and economically feasible in developing countries and can effectively identify major public health priorities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food chains (Ecology)
KW - Salmonella
KW - Food pathogens
KW - Public health
KW - Food contamination
KW - Pulsed-field gel electrophoresis
KW - Ciprofloxacin
KW - Mexico
N1 - Accession Number: 31323719; Zaidi, Mussaret B. 1; Email Address: mbzaidi@prodigy.net.mx; Calva, Juan Jose 2; Estrada-Garcia, Maria Teresa 3; Leon, Veronica 1; Vazquez, Gabriela 4; Figueroa, Gloria 4; Lopez, Estela 5; Contreras, Jesus 6; Abbott, Jason 7; Shaohua Zhao 7; McDermott, Patrick 7; Tollefson, Linda 8; Affiliations: 1: Hospital General O'Horan, Mérida, Mexico; 2: Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Mexico City, Mexico; 3: Centro de Investigacion y Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico; 4: Secretaría de Salud del Estado de Michoacan, Morelia, Mexico; 5: Laboratorio Estatal de Salud Pública y Hospital Central, Servicios de Salud del Estado de San Luis Potosí, San Luis Potosi, Mexico; 6: Hospital Infantil del Estado de Sonora, Hermosillo, Mexico; 7: Food and Drug Administration, Laurel, Maryland, USA; 8: Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Mar2008, Vol. 14 Issue 3, p429; Thesaurus Term: Food chains (Ecology); Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Public health; Thesaurus Term: Food contamination; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Ciprofloxacin; Subject: Mexico; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grinev, Andriyan
AU - Daniel, Sylvester
AU - Stramer, Susan
AU - Rossmann, Susan
AU - Caglioti, Sally
AU - Rios, Maria
T1 - Genetic Variability of West Nile Virus in US Blood Donors, 2002-2005.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/03//
VL - 14
IS - 3
M3 - Article
SP - 436
EP - 444
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - West Nile virus (WNV) was detected in the United States in 1999, has reoccurred every summer since, and has become endemic. Transfusion transmission was documented in 2002, and screening of blood donations for WNV began in 2003. We investigated genetic variation of WNV in human isolates obtained from specimens collected from 30 infected blood donors who tested positive for WNV RNA during 2002-2005. Complete genomic sequences of 8 isolates and structural gene sequences from 22 additional isolates were analyzed. We found some genetic diversity in isolates from different geographic regions and genetic divergence from reported sequences from epidemics in 1999-2001. Nucleotide divergence of structural genes showed a small increase from 2002 (0.18%) to 2005 (0.37%), suggesting absence of strong selective pressure and limited genetic evolution of WNV during that period. Nevertheless, WNV has continued to diverge from precursor isolates as geographic distribution of the virus has expanded. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - West Nile virus
KW - Viruses
KW - Blood donors
KW - Directed blood donations
KW - Nucleotides
KW - Genes
KW - Human genetics -- Variation
KW - United States
N1 - Accession Number: 31323720; Grinev, Andriyan 1; Daniel, Sylvester 1; Stramer, Susan 2; Rossmann, Susan 3; Caglioti, Sally 4; Rios, Maria 1; Email Address: maria.rios@fda.hhs.gov; Affiliations: 1: Food and Drug Administration, Bethesda, Maryland, USA; 2: American Red Cross, Gaithersburg, Maryland, USA; 3: Gulf Coast Regional Blood Center, Houston, Texas, USA; 4: Blood System Laboratories, Tempe, Arizona, USA; Issue Info: Mar2008, Vol. 14 Issue 3, p436; Thesaurus Term: West Nile virus; Thesaurus Term: Viruses; Subject Term: Blood donors; Subject Term: Directed blood donations; Subject Term: Nucleotides; Subject Term: Genes; Subject Term: Human genetics -- Variation; Subject: United States; Number of Pages: 9p; Illustrations: 3 Diagrams, 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shenghui Cui
AU - Jingyun Li
AU - Ziyong Sun
AU - Changqin Hu
AU - Shaohong Jin
AU - Yunchang Guo
AU - Lu Ran
AU - Yue Ma
T1 - Ciprofloxacin-Resistant Salmonella enterica Serotype Typhimurium, China.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/03//
VL - 14
IS - 3
M3 - Article
SP - 493
EP - 495
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - We characterized 44 Salmonella enterica serotype Typhimurium isolates from Tongji Hospital outpatients in Wuhan, China, May 2002-October 2005. All 31 ciprofloxacin-resistant isolates were also resistant to >8 other antimicrobial drugs and carried >2 mutations in GyrA and 1 mutation in ParC. Class 1 integrons were identified in 37 isolates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Quinolone antibacterial agents
KW - Salmonella
KW - Ciprofloxacin
KW - Salmonella enteritidis
KW - Outpatient medical care
KW - Wuhan (China)
KW - China
N1 - Accession Number: 31323732; Shenghui Cui 1; Jingyun Li 1; Ziyong Sun 2; Changqin Hu 1; Shaohong Jin 1; Yunchang Guo 3; Lu Ran 3; Yue Ma 1; Email Address: nicpbp@263.net; Affiliations: 1: State Food and Drug Administration, Beijing, People's Republic of China; 2: Huazhong University of Science and Technology, Wuhan, People's Republic of China; 3: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Issue Info: Mar2008, Vol. 14 Issue 3, p493; Thesaurus Term: Anti-infective agents; Thesaurus Term: Quinolone antibacterial agents; Thesaurus Term: Salmonella; Subject Term: Ciprofloxacin; Subject Term: Salmonella enteritidis; Subject Term: Outpatient medical care; Subject: Wuhan (China); Subject: China; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chalmers, Rachel M.
AU - Hadfield, Stephen J.
AU - Jackson, Colin J.
AU - Elwin, Kristin
AU - Lihua Xiao
AU - Hunter, Paul
T1 - Geographic Linkage and Variation in Cryptosporidium hominis.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/03//
VL - 14
IS - 3
M3 - Article
SP - 496
EP - 498
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - UK Cryptosporidium hominis isolates have previously shown slight PCR fragment length polymorphism at multiple loci. To further investigate transmission, we conducted a case-control study and sequenced the GP60 locus from 115 isolates. Nine subtypes were identified; IbA10G2 predominated. Having a non-IbA10G2 subtype was significantly linked to recent travel outside Europe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryptosporidium
KW - Polymerase chain reaction
KW - Cryptosporidiidae
KW - Polymerization
KW - Qualitative research
KW - Europe
KW - Great Britain
N1 - Accession Number: 31323733; Chalmers, Rachel M. 1; Email Address: rachel.chalmers@nphs.wales.nhs.uk; Hadfield, Stephen J. 1; Jackson, Colin J. 2; Elwin, Kristin 1; Lihua Xiao 3; Hunter, Paul 4; Affiliations: 1: National Public Health Service Microbiology, Swansea, Wales, UK; 2: Swansea University, Swansea, Wales, UK; 3: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 4: University of East Anglia, Norwich, UK; Issue Info: Mar2008, Vol. 14 Issue 3, p496; Thesaurus Term: Cryptosporidium; Subject Term: Polymerase chain reaction; Subject Term: Cryptosporidiidae; Subject Term: Polymerization; Subject Term: Qualitative research; Subject: Europe; Subject: Great Britain; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105684885
T1 - Genetic variability of West Nile virus in US blood donors, 2002-2005.
AU - Grinev A
AU - Daniel S
AU - Stramer S
AU - Rossmann S
AU - Caglioti S
AU - Rios M
AU - Grinev, Andriyan
AU - Daniel, Sylvester
AU - Stramer, Susan
AU - Rossmann, Susan
AU - Caglioti, Sally
AU - Rios, Maria
Y1 - 2008/03//
N1 - Accession Number: 105684885. Language: English. Entry Date: 20081107. Revision Date: 20161115. Publication Type: journal article. Journal Subset: Biomedical; USA. Grant Information: //Intramural NIH HHS/United States. NLM UID: 9508155.
KW - Blood Donors
KW - Flaviviridae
KW - Genetics
KW - West Nile Fever -- Epidemiology
KW - West Nile Fever
KW - Animals
KW - Evolution
KW - Nucleotides
KW - Primates
SP - 436
EP - 444
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
JA - EMERGING INFECT DIS
VL - 14
IS - 3
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - West Nile virus (WNV) was detected in the United States in 1999, has reoccurred every summer since, and has become endemic. Transfusion transmission was documented in 2002, and screening of blood donations for WNV began in 2003. We investigated genetic variation of WNV in human isolates obtained from specimens collected from 30 infected blood donors who tested positive for WNV RNA during 2002-2005. Complete genomic sequences of 8 isolates and structural gene sequences from 22 additional isolates were analyzed. We found some genetic diversity in isolates from different geographic regions and genetic divergence from reported sequences from epidemics in 1999-2001. Nucleotide divergence of structural genes showed a small increase from 2002 (0.18%) to 2005 (0.37%), suggesting absence of strong selective pressure and limited genetic evolution of WNV during that period. Nevertheless, WNV has continued to diverge from precursor isolates as geographic distribution of the virus has expanded.
SN - 1080-6040
AD - Food and Drug Administration, Bethesda, Maryland, USA
U2 - PMID: 18325259.
DO - 10.3201/eid1403.070463
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105684885&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105684896
T1 - Geographic linkage and variation in Cryptosporidium hominis.
AU - Chalmers RM
AU - Hadfield SJ
AU - Jackson CJ
AU - Elwin K
AU - Xiao L
AU - Hunter P
Y1 - 2008/03//
N1 - Accession Number: 105684896. Language: English. Entry Date: 20081107. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. NLM UID: 9508155.
KW - Cryptosporidiosis -- Epidemiology
KW - Cryptosporidiosis
KW - Cryptosporidium
KW - Animals
KW - Europe
KW - Kenya
KW - New Zealand
KW - Pakistan
KW - Travel
KW - Tunisia
KW - Turkey
SP - 496
EP - 498
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
JA - EMERGING INFECT DIS
VL - 14
IS - 3
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
SN - 1080-6040
AD - National Public Health Service Microbiology, Swansea, Wales, UK. rachel.chalmers@nphs.wales.nhs.uk
U2 - PMID: 18325272.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105684896&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Riggs, Margaret A.
AU - Rao, Carol Y.
AU - Brown, Clive M.
AU - Van Sickle, David
AU - Cummings, Kristin J.
AU - Dunn, Kevin H.
AU - Deddens, James A.
AU - Ferdinands, Jill
AU - Callahan, David
AU - Moolenaar, Ronald L.
AU - Pinkerton, Lynne E.
T1 - Resident cleanup activities, characteristics of flood-damaged homes and airborne microbial concentrations in New Orleans, Louisiana, October 2005
JO - Environmental Research
JF - Environmental Research
Y1 - 2008/03//
VL - 106
IS - 3
M3 - Article
SP - 401
EP - 409
SN - 00139351
AB - Background: Flooding in the greater New Orleans (GNO) area after the hurricanes caused extensive mold growth in homes resulting in public health concerns. Objectives: We conducted an environmental assessment of homes to determine the extent and type of microbial growth. Methods: We randomly selected 112 homes, stratified by water damage, and then visually assessed mold growth. Air samples from a subset of 20 homes were analyzed for culturable fungi, fungal spores, and markers of mold ((1→3, 1→6)-β-d-glucans) and bacteria (endotoxin). Results: Visible mold growth occurred in 49 (44%) homes; 18 (16%) homes had >50% mold coverage. Flood levels were >6ft at 20 (19%), 3–6ft at 20 (19%), and <3ft at 28 (26%) homes out of 107; no flooding at 39 (36%) homes. The residents spent an average of 18h (range: 1–84) doing heavy cleaning and of those, 22 (38%) reported using an N-95 or other respirator. Visible mold growth was significantly associated with flood height ⩾3ft and the predominant fungi indoors were Aspergillus and Penicillium species, which were in higher concentrations in homes with a flood level ⩾3ft. Geometric mean (GM) levels of endotoxin were as high as 40.2EU/m3, while GM glucan levels were as high as 3.5μg/m3 even when flooding was ⩽3ft. Conclusions: Based on our observations of visible mold, we estimated that elevated mold growth was present in 194,000 (44%) homes in the GNO area and 70,000 (16%) homes had heavy mold growth. Concentrations of endotoxin and glucans exceeded those previously associated with health effects. With such high levels of microbial growth following flooding, potentially harmful inhalation exposures can be present for persons entering or cleaning affected homes. Persons exposed to water-damaged homes should follow the CDC recommendations developed following the 2005 hurricanes for appropriate respiratory precautions. [Copyright &y& Elsevier]
AB - Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental health
KW - Microbial growth
KW - Molds (Fungi)
KW - Hurricanes -- Environmental aspects
KW - Restorative drying
KW - New Orleans (La.) -- Environmental conditions
KW - New Orleans (La.)
KW - Louisiana
KW - Endotoxin
KW - Flooding
KW - Glucan
KW - Hurricane
KW - Mold
N1 - Accession Number: 31148246; Riggs, Margaret A. 1,2; Email Address: MRiggs@cdc.gov; Rao, Carol Y. 1,3; Brown, Clive M. 4; Van Sickle, David 1,4; Cummings, Kristin J. 1,5; Dunn, Kevin H. 4; Deddens, James A. 2; Ferdinands, Jill 4; Callahan, David 4; Moolenaar, Ronald L. 4; Pinkerton, Lynne E. 2; Affiliations: 1: Epidemic Intelligence Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA; 2: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health (NIOSH), CDC, Cincinnati, OH, USA; 3: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases (NCID), CDC, Atlanta, GA, USA; 4: Division of Environmental Hazards and Health Effects, National Center for Environmental Health (NCEH), CDC, Atlanta, GA, USA; 5: Division of Respiratory Disease Studies, NIOSH, CDC, Morgantown, WV, USA; Issue Info: Mar2008, Vol. 106 Issue 3, p401; Thesaurus Term: Environmental health; Thesaurus Term: Microbial growth; Thesaurus Term: Molds (Fungi); Subject Term: Hurricanes -- Environmental aspects; Subject Term: Restorative drying; Subject Term: New Orleans (La.) -- Environmental conditions; Subject: New Orleans (La.); Subject: Louisiana; Author-Supplied Keyword: Endotoxin; Author-Supplied Keyword: Flooding; Author-Supplied Keyword: Glucan; Author-Supplied Keyword: Hurricane; Author-Supplied Keyword: Mold; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.envres.2007.11.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31148246&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pérez-De La Cruz, Verónica
AU - Konigsberg, Mina
AU - Pedraza-Chaverri, Jos
AU - Herrera-Mundo, Nieves
AU - Díaz-Muñoz, Mauricio
AU - Morán, Julio
AU - Fortoul-Van Der Goes, Teresa
AU - Rondán-Zárate, Adrián
AU - Maldonado, Perla D.
AU - Ali, Syed F.
AU - Santamaría, Abel
T1 - Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats.
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
Y1 - 2008/03//
VL - 27
IS - 5
M3 - Article
SP - 1075
EP - 1085
PB - Wiley-Blackwell
SN - 0953816X
AB - Excessive calcium is responsible for triggering different potentially fatal metabolic pathways during neurodegeneration. In this study, we evaluated the role of calcium on the oxidative damage produced in an in vitro combined model of excitotoxicity/energy deficit produced by the co-administration of quinolinate and 3-nitropropionate to brain synaptosomal membranes. Synaptosomal fractions were incubated in the presence of subtoxic concentrations of these agents (21 and 166 µm, respectively). In order further to characterize possible toxic mechanisms involved in oxidative damage in this experimental paradigm, agents with different properties – dizocilpine, acetyll-carnitine, iron porphyrinate and S-allylcysteine – were tested at increasing concentrations (10–1000 µm). Lipid peroxidation was assessed by the formation of thiobarbituric acid-reactive substances. For confirmatory purposes, additional fractions were incubated in parallel in the presence of the intracellular calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid-acetoxymethyl ester (BAPTA-AM). Under physiological conditions of extracellular calcium availability, synaptomes exposed to both toxins displayed an increased lipoperoxidation (76% above controls), and this effect was partially attenuated by the tested agents as follows: dizocilpine = iron porphyrinate > acetyll-carnitine > S-allylcysteine. When the incubation medium was deprived of calcium, the lipoperoxidative effect achieved in this experimental paradigm was still high (49% above the control), and the order of attenuation was: iron porphyrinate > S-allylcysteine > acetyll-carnitine > dizocilpine. BAPTA-AM was effective in preventing the pro-oxidant action of both toxins, promoting even lower peroxidative levels than those quantified under basal conditions. Our results suggest that the lipid peroxidation induced in synaptosomal fractions by quinolinate plus 3-nitropropionate is largely dependent on the cytoplasmic concentrations of calcium. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALCIUM
KW - NEURODEGENERATION
KW - PEROXIDATION
KW - LIPIDS
KW - TOXINS
KW - 3-nitropropionic acid
KW - cytoplasmic Ca2+
KW - lipid peroxidation
KW - quinolinate
KW - synergism
N1 - Accession Number: 31336309; Pérez-De La Cruz, Verónica 1,2 Konigsberg, Mina 2 Pedraza-Chaverri, Jos 3 Herrera-Mundo, Nieves 1 Díaz-Muñoz, Mauricio 4 Morán, Julio 5 Fortoul-Van Der Goes, Teresa 6 Rondán-Zárate, Adrián 6 Maldonado, Perla D. 7 Ali, Syed F. 8 Santamaría, Abel 1,8; Email Address: absada@yahoo.com; Affiliation: 1: Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, S.S.A., México D.F. 14269, México. 2: Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa. A.P. 55-535, C.P 09340, México D.F., México. 3: Departamento de Biología, Facultad de Química, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, México D.F. 04510, México. 4: Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Campus UNAM-Juriquilla, Querétaro 76230, QRO, Mexico. 5: Departamento de Neurosciencias, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, México D.F. 04510, México. 6: Departamento de Biologia Celular, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, México D.F. 04510, México. 7: Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, S.S.A., México D.F. 14269, México. 8: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research / Food and Drug Administration, Jefferson, AR 72079, USA.; Source Info: Mar2008, Vol. 27 Issue 5, p1075; Subject Term: CALCIUM; Subject Term: NEURODEGENERATION; Subject Term: PEROXIDATION; Subject Term: LIPIDS; Subject Term: TOXINS; Author-Supplied Keyword: 3-nitropropionic acid; Author-Supplied Keyword: cytoplasmic Ca2+; Author-Supplied Keyword: lipid peroxidation; Author-Supplied Keyword: quinolinate; Author-Supplied Keyword: synergism; Number of Pages: 11p; Illustrations: 1 Diagram, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1460-9568.2008.06088.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morehouse, Kim M.
AU - Nyman, Patricia J.
AU - McNeal, Timothy P.
AU - DiNovi, Michael J.
AU - Perfetti, Gracia A.
T1 - Survey of furan in heat processed foods by headspace gas chromatography/mass spectrometry and estimated adult exposure.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/03//
VL - 25
IS - 3
M3 - Article
SP - 259
EP - 264
PB - Taylor & Francis Ltd
SN - 19440049
AB - Furan is a suspected human carcinogen that is formed in some processed foods at low ng per g levels. Recent improvements in analytical methodology and scientific instrumentation have made it possible to accurately measure the amount of furan in a wide variety of foods. Results from analysis of more than 300 processed foods are presented. Furan was found at levels ranging from non-detectable (LOD, 0.2-0.9 ng g-1) to over 100 ng g-1. Exposure estimates for several adult food types were calculated, with brewed coffee being the major source of furan in the adult diet (0.15 µg kg-1 body weight day-1). Estimates of mean exposure to furan for different subpopulations were calculated. For consumers 2 years and older, the intake is estimated to be about 0.2 µg kg-1 body weight day-1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Furans
KW - Carcinogens
KW - Processed foods
KW - Coffee
KW - Instant coffee
KW - Consumers
KW - Diet
KW - Body weight
KW - Adults
KW - Furan
KW - gas chromatography
KW - headspace
KW - mass spectroscopy
KW - processed food
N1 - Accession Number: 31134671; Morehouse, Kim M. 1; Email Address: kim.morehouse@fda.hhs.gov; Nyman, Patricia J. 1; McNeal, Timothy P. 1; DiNovi, Michael J. 1; Perfetti, Gracia A. 1; Affiliations: 1: Food and Drug Administration-CFSAN, College Park, MD 20740, USA; Issue Info: Mar2008, Vol. 25 Issue 3, p259; Thesaurus Term: Furans; Thesaurus Term: Carcinogens; Subject Term: Processed foods; Subject Term: Coffee; Subject Term: Instant coffee; Subject Term: Consumers; Subject Term: Diet; Subject Term: Body weight; Subject Term: Adults; Author-Supplied Keyword: Furan; Author-Supplied Keyword: gas chromatography; Author-Supplied Keyword: headspace; Author-Supplied Keyword: mass spectroscopy; Author-Supplied Keyword: processed food; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311920 Coffee and Tea Manufacturing; NAICS/Industry Codes: 111339 Other Noncitrus Fruit Farming; NAICS/Industry Codes: 111330 Non-citrus fruit and tree nut farming; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/02652030701552949
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Begley, T. H.
AU - Hsu, W.
AU - Noonan, G.
AU - Diachenko, G.
T1 - Migration of fluorochemical paper additives from food-contact paper into foods and food simulants.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/03//
VL - 25
IS - 3
M3 - Article
SP - 384
EP - 390
PB - Taylor & Francis Ltd
SN - 19440049
AB - Fluorochemical-treated paper was tested to determine the amount of migration that occurs into foods and food-simulating liquids and the characteristics of the migration. Migration characteristics of fluorochemicals from paper were examined in Miglyol, butter, water, vinegar, water-ethanol solutions, emulsions and pure oil containing small amounts of emulsifiers. Additionally, microwave popcorn and chocolate spread were used to investigate migration. Results indicate that fluorochemicals paper additives do migrate to food during actual package use. For example, we found that microwave popcorn contained 3.2 fluorochemical mg kg-1 popcorn after popping and butter contained 0.1 mg kg-1 after 40 days at 4°C. Tests also indicate that common food-simulating liquids for migration testing and package material evaluation might not provide an accurate indication of the amount of fluorochemical that actually migrates to food. Tests show that oil containing small amounts of an emulsifier can significantly enhance migration of a fluorochemical from paper. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Emigration & immigration
KW - Food
KW - Water
KW - Paper
KW - Butter
KW - Vinegar
KW - Emulsions
KW - Fats & oils
KW - Popcorn
KW - Fluorochemicals
KW - food packaging
KW - food simulants
KW - migration
N1 - Accession Number: 31134674; Begley, T. H. 1; Email Address: timothy.begley@fda.hhs.gov; Hsu, W. 2; Noonan, G. 1; Diachenko, G. 1; Affiliations: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; 2: Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, MD 20742, USA; Issue Info: Mar2008, Vol. 25 Issue 3, p384; Thesaurus Term: Emigration & immigration; Thesaurus Term: Food; Thesaurus Term: Water; Subject Term: Paper; Subject Term: Butter; Subject Term: Vinegar; Subject Term: Emulsions; Subject Term: Fats & oils; Subject Term: Popcorn; Author-Supplied Keyword: Fluorochemicals; Author-Supplied Keyword: food packaging; Author-Supplied Keyword: food simulants; Author-Supplied Keyword: migration; NAICS/Industry Codes: 311512 Creamery Butter Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 424110 Printing and Writing Paper Merchant Wholesalers; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 311941 Mayonnaise, Dressing, and Other Prepared Sauce Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/02652030701513784
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31134674&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Moy, Ernest
AU - Greenberg, Linda G.
AU - Borsky, Amanda E.
T1 - Community Variation: Disparities In Health Care Quality Between Asian And White Medicare Beneficiaries.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/03//Mar/Apr2008
VL - 27
IS - 2
M3 - Article
SP - 538
EP - 549
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Few studies have focused on Asian-white disparities. This study examines the use of selected cancer screening and diabetes services under the traditional Medicare program of whites and Asians by socioeconomic status and among U.S. metropolitan statistical areas in which elderly Asians reside. It demonstrates that existing data, with enrichment, can be used to examine Asian-white disparities. It finds that Asians often receive poorer quality of care than whites, but disparities differ among metropolitan areas. This research enables policymakers to better understand and target resources to address Asian-white disparities at the national and local community levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISCRIMINATION in medical care
KW - ASIANS
KW - MEDICAL care
KW - HEALTH insurance
KW - MEDICAL laws & legislation
KW - HEALTH care reform
KW - MEDICAL ethics
KW - PUBLIC welfare
KW - NATIONAL health services
KW - UNITED States
N1 - Accession Number: 31273419; Moy, Ernest 1; Email Address: ernest.moy@ahrq.hhs.gov Greenberg, Linda G. 2 Borsky, Amanda E. 3; Affiliation: 1: Medical Officer, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland 2: Senior Adviser on Patient Safety, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland 3: Associate Research Analyst, CNA Corporation, Alexandria, Virginia; Source Info: Mar/Apr2008, Vol. 27 Issue 2, p538; Subject Term: DISCRIMINATION in medical care; Subject Term: ASIANS; Subject Term: MEDICAL care; Subject Term: HEALTH insurance; Subject Term: MEDICAL laws & legislation; Subject Term: HEALTH care reform; Subject Term: MEDICAL ethics; Subject Term: PUBLIC welfare; Subject Term: NATIONAL health services; Subject Term: UNITED States; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Document Type: Article
L3 - 10.1377/hlthaff.27.2.538
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31273419&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Cohen, Steven B.
AU - Clancy, Carolyn M.
T1 - AHRQ And Data Collection.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/03//Mar/Apr2008
VL - 27
IS - 2
M3 - Letter
SP - 586
EP - 587
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - A letter to the editor is presented in response to the article on health survey in the November/December 2007 issue.
KW - LETTERS to the editor
KW - HEALTH surveys
N1 - Accession Number: 31273436; Cohen, Steven B. 1 Clancy, Carolyn M. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: Mar/Apr2008, Vol. 27 Issue 2, p586; Subject Term: LETTERS to the editor; Subject Term: HEALTH surveys; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105695904
T1 - Community variation: disparities in health care quality between Asian and white Medicare beneficiaries.
AU - Moy E
AU - Greenberg LG
AU - Borsky AE
Y1 - 2008/03//Mar/Apr2008
N1 - Accession Number: 105695904. Language: English. Entry Date: 20081121. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Asians
KW - Medicare
KW - Quality of Health Care -- Evaluation -- United States
KW - Aged
KW - Aged, 80 and Over
KW - Cancer Screening
KW - Clinical Indicators
KW - Coding
KW - Data Analysis Software
KW - Diabetes Mellitus
KW - Fee for Service Plans
KW - Female
KW - Logistic Regression
KW - Male
KW - Minority Groups
KW - Probability Sample
KW - Socioeconomic Factors
KW - United States
KW - Urban Areas
KW - Whites
KW - Human
SP - 538
EP - 549
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 2
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Few studies have focused on Asian-white disparities. This study examines the use of selected cancer screening and diabetes services under the traditional Medicare program of whites and Asians by socioeconomic status and among U.S. metropolitan statistical areas in which elderly Asians reside. It demonstrates that existing data, with enrichment, can be used to examine Asian-white disparities. It finds that Asians often receive poorer quality of care than whites, but disparities differ among metropolitan areas. This research enables policymakers to better understand and target resources to address Asian-white disparities at the national and local community levels.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland, USA. ernest.moy@ahrq.hhs.gov
U2 - PMID: 18332512.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Sustainable participation in regular exercise amongst older people: Developing an action research approach.
AU - Davies, Jeanne
AU - Lester, Carolyn
AU - O'Neill, Martin
AU - Williams, Gareth
JO - Health Education Journal
JF - Health Education Journal
Y1 - 2008/03//
VL - 67
IS - 1
SP - 45
EP - 55
SN - 00178969
N1 - Accession Number: 31278640; Author: Davies, Jeanne: 1 Author: Lester, Carolyn: 2 email: carolyn.lester@nphs.wales.nhs.uk. Author: O'Neill, Martin: 1,3 Author: Williams, Gareth: 1 ; Author Affiliation: 1 School of Social Sciences, Cardiff University: 2 National Public Health Service for Wales: 3 University of Glamorgan; No. of Pages: 11; Language: English; Publication Type: Article; Update Code: 20150711
N2 - The article reports on the Triangle Project's health promotion activities in a post-industrial community, where activities for healthy living were established in response to the expressed needs of community members. It was observed that the social aspects of the activities were highly valued by the participants and helped in maintaining the sustainability of the class.
KW - *HEALTH promotion
KW - *PREVENTIVE health services
KW - *ATTITUDES toward health
KW - *HEALTH behavior
KW - *HEALTH education
KW - action research
KW - exercise
KW - older women
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
T1 - Prevalence, awareness, treatment, and control of hypertension in the Jackson Heart Study.
AU - Wyatt, Sharon B.
AU - Akylbekova, Ermeg L.
AU - Wofford, Marion R.
AU - Coady, Sean A.
AU - Walker, Evelyn R.
AU - Andrew, Michael E.
AU - Keahey, Wanda J.
AU - Taylor, Herman A.
AU - Jones, Daniel W.
JO - Hypertension (0194911X)
JF - Hypertension (0194911X)
Y1 - 2008/03//
VL - 51
IS - 3
SP - 650
EP - 656
SN - 0194911X
N1 - Accession Number: 31138363; Author: Wyatt, Sharon B.: 1,2,3 email: swyatt@son.umsmed.edu. Author: Akylbekova, Ermeg L.: 4 Author: Wofford, Marion R.: 2,3 Author: Coady, Sean A.: 5 Author: Walker, Evelyn R.: 6 Author: Andrew, Michael E.: 7 Author: Keahey, Wanda J.: 3,4,8 Author: Taylor, Herman A.: 3,4,9,10 Author: Jones, Daniel W.: 2,3 ; Author Affiliation: 1 School of Nursing, University of Mississippi Medical Center, Jackson.: 2 Division of Hypertension, University of Mississippi Medical Center, Jackson.: 3 School of Medicine, Jackson Heart Study Examination Center, University of Mississippi Medical Center, Jackson.: 4 Jackson Heart Study Coordinating Center, Jackson State University, Miss.: 5 Division of Population and Prevention Science, National Heart, Lung, and Blood Institute, Bethesda, Md.: 6 Jackson Heart Study Field Center, National Heart, Lung, and Blood Institute, Jackson, Miss.: 7 Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV.: 8 Department of Pharmacy Services, University of Mississippi Medical Center, Jackson.: 9 Division of Cardiology, University of Mississippi Medical Center, Jackson.: 10 Jackson Heart Study Undergraduate Training Center, Tougaloo College, Jackson, Miss.; No. of Pages: 7; Language: English; Publication Type: journal article; Update Code: 20080404
N2 - African Americans have higher reported hypertension prevalence and lower control rates than other ethnic groups in the United States. Hypertension prevalence, awareness, treatment, and control (outcomes) and potentially associated demographic, lifestyle, comorbidity, and health care access factors were examined in 5249 adult participants (3362 women and 1887 men) aged 21 to 94 years enrolled in the Jackson Heart Study. Hypertension prevalence (62.9%), awareness (87.3%), treatment (83.2%), and control (66.4%) were high. Control declined with advancing age; estimates for all of the outcomes were higher for women compared with men. Lower socioeconomic status was associated with prevalence and control. Smoking was negatively associated with awareness and treatment, particularly among men. Comorbidities (diabetes, chronic kidney disease, and cardiovascular disease), likely driven by the high rates of obesity, correlated with hypertension prevalence, awareness, treatment, and control. Lack of health insurance was marginally associated with poorer control, whereas use of preventive care was positively associated with prevalence, awareness, and treatment, particularly among men. In comparisons with the 1994-2004 National Health and Nutrition Examination Survey data adjusted to Jackson Heart Study sex, age, and socioeconomic status distribution, control rates among Jackson Heart Study participants appeared to be higher than in their national counterparts and similar to that of whites. These results suggest that public health efforts to increase awareness and treatment among African Americans have been relatively effective. The Jackson Heart Study data indicate that better control rates can be achieved in this high-risk population. ABSTRACT FROM AUTHOR
KW - *HYPERTENSION
KW - *EPIDEMIOLOGY
KW - ETHNICITY
KW - POPULATION
KW - blood pressure
KW - detection and control
KW - epidemiology
KW - ethnicity
KW - hypertension
KW - population
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DP - EBSCOhost
DB - s3h
ER -
TY - CONF
AU - Hagan, Michael
AU - Encinosa, William
T1 - Health Care Markets: Concepts, Data, Measures, and Current Research Challenges.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2008///Spring2008
VL - 45
IS - 1
M3 - Proceeding
SP - 15
EP - 18
SN - 00469580
AB - Information about several papers discussed at the conference sponsored by the Agency for Healthcare Research and Quality (AHRQ) is presented. Topics include public and private policy context for understanding health care and forces markets, research on health care costs, and the assessment of the impact of consolidation in the hospital market. The conference aims to develop research agenda items necessary to address policy-relevant gaps in the understanding of health care markets.
KW - CONFERENCES & conventions
KW - MEDICAL care
KW - CONGRESSES
KW - MEDICAL care costs -- Congresses
KW - UNITED States
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 32540168; Hagan, Michael 1; Encinosa, William 2; Affiliations: 1: Senior Economist, Extramural Program Officer, Center for Delivery, Organization, and Markets Agency for Healthcare Research and Quality Rockville, Maryland; 2: Senior Economist, Center for Delivery, Organization, and Markets Agency for Healthcare Research and Quality Rockville, Maryland; Issue Info: Spring2008, Vol. 45 Issue 1, p15; Thesaurus Term: CONFERENCES & conventions; Thesaurus Term: MEDICAL care; Subject Term: CONGRESSES; Subject Term: MEDICAL care costs -- Congresses; Subject: UNITED States ; Company/Entity: UNITED States. Agency for Healthcare Research & Quality; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 4p; Document Type: Proceeding
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105765485
T1 - Health care markets: concepts, data, measures, and current research challenges.
AU - Hagan M
AU - Encinosa W
Y1 - 2008///Spring2008
N1 - Accession Number: 105765485. Language: English. Entry Date: 20080711. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Health Care Costs
KW - Health Policy -- Economics
KW - Congresses and Conferences
KW - United States Department of Health and Human Services
KW - United States
SP - 15
EP - 18
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 45
IS - 1
PB - Sage Publications Inc.
SN - 0046-9580
AD - Center for Delivery, Organization, and Markets Agency for Healthcare Research and Quality, Rockville, USA.
U2 - PMID: 18524289.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Garber, Erica A.E.
AU - O'Brien, Thomas W.
T1 - Detection of Ricin in Food Using Electrochemiluminescence-Based Technology.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/03//Mar/Apr2008
VL - 91
IS - 2
M3 - Article
SP - 376
EP - 382
PB - AOAC International
SN - 10603271
AB - The article discusses the results of a study involving the detection of ricin in food using electrochemiluminescence (ECL)-based technology. The method included the use of a monoclonal capture antibody coupled with either a polyclonal or monoclonal detector antibody. The ECL method was found to be uniquely suited for the screening of samples for ricin.
KW - RICIN
KW - FOOD contamination
KW - TOXICOLOGY
KW - ANALYTICAL chemistry
KW - PHARMACOLOGY
N1 - Accession Number: 31886256; Garber, Erica A.E. 1 O'Brien, Thomas W. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Bioanalytical Chemistry, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740 2: Tetracore Inc., 9901 Belward Campus Dr, Rockville, MD 20850; Source Info: Mar/Apr2008, Vol. 91 Issue 2, p376; Subject Term: RICIN; Subject Term: FOOD contamination; Subject Term: TOXICOLOGY; Subject Term: ANALYTICAL chemistry; Subject Term: PHARMACOLOGY; Number of Pages: 7p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ali, Laila
AU - Perfetti, Gracia
AU - Diachenko, Gregory
T1 - Rapid Method for the Determination of Coumarin, Vanillin, and Ethyl Vanillin in Vanilla Extract by Reversed-Phase Liquid Chromatography with Ultraviolet Detection.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/03//Mar/Apr2008
VL - 91
IS - 2
M3 - Article
SP - 383
EP - 386
PB - AOAC International
SN - 10603271
AB - The article discusses the results of a study involving the evaluation of a rapid method for the determination of courmarin, vanillin and ethyl vanillin in vanilla extracted by reversed-phase liquid chromatography with ultraviolet detection. None of the samples surveyed contained courmarin but they contain vanillin and ethyl vanillin.
KW - LIQUID chromatography
KW - ULTRAVIOLET detectors
KW - VANILLA
KW - FOOD contamination
KW - CHROMATOGRAPHIC analysis
N1 - Accession Number: 31886257; Ali, Laila 1; Email Address: Laila.Ali@fda.hhs.gov Perfetti, Gracia 1 Diachenko, Gregory 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, College Park, MD 20740; Source Info: Mar/Apr2008, Vol. 91 Issue 2, p383; Subject Term: LIQUID chromatography; Subject Term: ULTRAVIOLET detectors; Subject Term: VANILLA; Subject Term: FOOD contamination; Subject Term: CHROMATOGRAPHIC analysis; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nyman, Patricia J.
AU - Morehouse, Kim M.
AU - Perfetti, Gracia A.
AU - Diachenio, Gregory W.
AU - Holcomb, Jim R.
T1 - Single-Laboratory Validation of a Method for the Determination of Furan in Foods by Using Headspace Gas Chromatography/Mass Spectrometry, Part 2—Low-Moisture Snack Foods.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/03//Mar/Apr2008
VL - 91
IS - 2
M3 - Article
SP - 414
EP - 421
PB - AOAC International
SN - 10603271
AB - The article discusses the results of a study concerning single-laboratory validation of a method for the determination of furan in low-moisture snack foods using headspace gas chromatography/mass spectrometry. The results were consistent with results obtained for similar snack foods analyzed by a U.S. Food and Drug Administration field laboratory.
KW - FURANS
KW - SNACK foods
KW - FOOD -- Analysis
KW - TECHNICAL chemistry
KW - GAS chromatography/Mass spectrometry (GC-MS)
N1 - Accession Number: 31886262; Nyman, Patricia J. 1; Email Address: patricia.nyman@fda.hhs.gov Morehouse, Kim M. 1 Perfetti, Gracia A. 1 Diachenio, Gregory W. 1 Holcomb, Jim R. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-706, 5100 Paint Branch Pkwy, College Park, MD 20740 2: U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St, NE, Atlanta, GA 30309; Source Info: Mar/Apr2008, Vol. 91 Issue 2, p414; Subject Term: FURANS; Subject Term: SNACK foods; Subject Term: FOOD -- Analysis; Subject Term: TECHNICAL chemistry; Subject Term: GAS chromatography/Mass spectrometry (GC-MS); Number of Pages: 8p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schenck, Frank J.
AU - Brown, Amy N.
AU - Podhorniak, Lynda V.
AU - Parker, Alesia
AU - Reliford, Michelle
AU - Wong, Jon W.
T1 - A Rapid Multiresidue Method for Determination of Pesticides in Fruits and Vegetables by Using Acetonitrile Extraction/Partitioning and Solid-Phase Extraction Column Cleanup.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/03//Mar/Apr2008
VL - 91
IS - 2
M3 - Article
SP - 422
EP - 438
PB - AOAC International
SN - 10603271
AB - The article discusses the results of a study concerning the evaluation of a rapid multiresidue method for determination of pesticides in fruits and vegetables by using acetonitrile extraction/partitioning and solid-phase extraction column clean-up. The modified method resulted in 65 percent reduction in solvent usage.
KW - PESTICIDE residues in food
KW - FOOD contamination
KW - ACETONITRILE
KW - SOLID phase extraction
KW - CHROMATOGRAPHIC analysis
N1 - Accession Number: 31886263; Schenck, Frank J. 1; Email Address: Frank.Schenck@fda.hhs.gov Brown, Amy N. 2 Podhorniak, Lynda V. 3 Parker, Alesia 1 Reliford, Michelle 2 Wong, Jon W. 4; Affiliation: 1: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309 2: Florida Department of Agriculture and Consumer Services, Chemical Residue Laboratory, Tallahassee, FL 32399 3: U.S. Environmental Protection Agency, Environmental Science Center, Ft Meade, MD 20755 4: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740; Source Info: Mar/Apr2008, Vol. 91 Issue 2, p422; Subject Term: PESTICIDE residues in food; Subject Term: FOOD contamination; Subject Term: ACETONITRILE; Subject Term: SOLID phase extraction; Subject Term: CHROMATOGRAPHIC analysis; Number of Pages: 17p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rummel, Nathan
AU - Shaikh, Badar
T1 - Determination of Albendazole and Its Metabolites in the Muscle Tissue of Hybrid Striped and Largemouth Bass Using Liquid Chromatography with Fluorescence Detection.
JO - Journal of AOAC International
JF - Journal of AOAC International
Y1 - 2008/03//Mar/Apr2008
VL - 91
IS - 2
M3 - Article
SP - 469
EP - 477
PB - AOAC International
SN - 10603271
AB - The article discusses the result of the study concerning the determination of albendazole and its metabolites in the muscle tissue of hybrid striped and largemouth bass using liquid chromatography (LC) with fluorescence detection. The method was found to be accurate, precise and sensitive in determining ABZ and its metabolites in largemouth and hybrid striped bass.
KW - ALBENDAZOLE
KW - BASSES (Fish)
KW - METABOLITES
KW - LIQUID chromatography
KW - CHROMATOGRAPHIC analysis
N1 - Accession Number: 31886267; Rummel, Nathan 1 Shaikh, Badar 1; Email Address: badaruddin.shaikh@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd, Laurel, MD 20708; Source Info: Mar/Apr2008, Vol. 91 Issue 2, p469; Subject Term: ALBENDAZOLE; Subject Term: BASSES (Fish); Subject Term: METABOLITES; Subject Term: LIQUID chromatography; Subject Term: CHROMATOGRAPHIC analysis; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mukherjee, Amit
AU - Mammel, Mark K.
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Altered Utilization of N-Acetyl-D-Galactosamine by Escherichia coli O157:H7 from the 2006 Spinach Outbreak.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008/03//
VL - 190
IS - 5
M3 - Article
SP - 30
EP - 30
SN - 00219193
AB - In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete coding sequences for enzyme IIA (EIIA)Aga/Gam, EIIBAga, EIICAga, and EIIDAga of the Aga PTS are present, E. coli O157:H7 strains normally are able to utilize Aga as a sole carbon source. The Gam PTS complex, in contrast, lacks EIICGam, and consequently, E. coli O157:H7 strains cannot utilize Gam. Phenotypic analyses of 120 independent isolates of E. coli O157:H7 from our culture collection revealed that the overwhelming majority (118/120) displayed the expected Aga+ Gam- phenotype. Yet, when 194 individual isolates, derived from a 2006 spinach-associated E. coli O157:H7 outbreak, were analyzed, all (194/194) displayed an Aga- Gam- phenotype. Comparison of aga/gam sequences from two spinach isolates with those of EDL933 and Sakai revealed a single nucleotide change (G:C→A:T) in the agaF gene in the spinach-associated isolates. The base substitution in agaF, which encodes EIIAAga/Gam of the PTS, changes a conserved glycine residue to serine (Gly91Ser). Pyrosequencing of this region showed that all spinach-associated E. coli O157:H7 isolates harbored this same G:C→A:T substitution. Notably, when agaF+ was cloned into an expression vector and transformed into six spinach isolates, all (6/6) were able to grow on Aga, thus demonstrating that the Gly91Ser substitution underlies the Aga- phenotype in these isolates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli O157:H7
KW - ESCHERICHIA coli
KW - FOODBORNE diseases
KW - SPINACH
KW - ENTEROBACTERIACEAE
KW - ENZYMES
N1 - Accession Number: 31200637; Mukherjee, Amit 1 Mammel, Mark K. 1 LeClerc, J. Eugene 1 Cebula, Thomas A. 1; Email Address: Thomas.Cebula@fda.hhs.gov; Affiliation: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland 20708; Source Info: Mar2008, Vol. 190 Issue 5, p30; Subject Term: ESCHERICHIA coli O157:H7; Subject Term: ESCHERICHIA coli; Subject Term: FOODBORNE diseases; Subject Term: SPINACH; Subject Term: ENTEROBACTERIACEAE; Subject Term: ENZYMES; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.01737-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dasari, Mina S.
AU - Richards, Kristy M.
AU - Alt, Mikaela L.
AU - Crawford, Clark F. P.
AU - Schleiden, Amanda
AU - Ingram, Jai
AU - Hamidou, Abdel Aziz Amadou
AU - Williams, Angela
AU - Chernovitz, Patricia A.
AU - Luo, Rensheng
AU - Sun, Grace Y.
AU - Luchtefeld, Ron
AU - Smiths, Robert E.
T1 - Synthesis of Diapocynin.
JO - Journal of Chemical Education
JF - Journal of Chemical Education
Y1 - 2008/03//
VL - 85
IS - 3
M3 - Article
SP - 411
EP - 412
SN - 00219584
AB - The article presents a study that describes the synthesizing process of diapocynin. The study was administered using two grams of apocynin which was dissolved in a 200 milliliter of deionized water by stirring and heating the solution until it reaches its boiling point and dried overnight through desiccators and fourier transform infrared spectroscopy. The study reveals that some triapocynin impurity in the solution was generated wherein small quantities of unreacted apocynin were eliminated through washing with boiling water which optimizes its chemical shifts. However, the author stresses that the procedure should not be regarded to have an effect on the policy and regulations set by the U.S. Food and Drug Administration.
KW - ORGANIC compounds
KW - CHEMICAL processes
KW - ORGANIC chemistry
KW - BIOACTIVE compounds
KW - EXPERIMENTAL programs
KW - ACTIVITY programs in education
KW - EXPERIMENTS
KW - CHEMICAL reactions
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31140189; Dasari, Mina S. 1 Richards, Kristy M. 1 Alt, Mikaela L. 1 Crawford, Clark F. P. 1 Schleiden, Amanda 1 Ingram, Jai 1 Hamidou, Abdel Aziz Amadou 1 Williams, Angela 1 Chernovitz, Patricia A. 1 Luo, Rensheng 2 Sun, Grace Y. 3 Luchtefeld, Ron 4 Smiths, Robert E. 1,4; Email Address: robert.smith@fda.hhs.gov; Affiliation: 1: Chemistry Department, Park University, Parkville, MO 64152 2: Department of Chemistry and Biochemistry, University of Missouri—St. Louis, St. Louis, MO 63121 3: Biochemistry Department, University of Missouri, Columbia, MO 65212 4: Total Diet and Pesticide Research Center, U. S. Food and Drug Administration, 11510 W 80th St., Lenexa, KS 66214; Source Info: Mar2008, Vol. 85 Issue 3, p411; Subject Term: ORGANIC compounds; Subject Term: CHEMICAL processes; Subject Term: ORGANIC chemistry; Subject Term: BIOACTIVE compounds; Subject Term: EXPERIMENTAL programs; Subject Term: ACTIVITY programs in education; Subject Term: EXPERIMENTS; Subject Term: CHEMICAL reactions; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 2p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Englberger, Lois
AU - Schierle, Joseph
AU - Kraemer, Klaus
AU - Aalbersberg, William
AU - Dolodolotawake, Usaia
AU - Humphries, Julia
AU - Graham, Robin
AU - Reid, Anne P.
AU - Lorens, Adelino
AU - Albert, Kiped
AU - Levendusky, Amy
AU - Johnson, Eliaser
AU - Paul, Yumiko
AU - Sengebau, Fernando
T1 - Carotenoid and mineral content of Micronesian giant swamp taro (Cyrtosperma) cultivars
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2008/03//
VL - 21
IS - 2
M3 - Article
SP - 93
EP - 106
SN - 08891575
AB - Abstract: Dietary change in Micronesia has led to serious problems of vitamin A deficiency and other nutritionally-related health problems. It is essential to identify nutrient-rich indigenous foods that may be promoted for health improvements. Giant swamp taro (Cyrtosperma merkusii) is important for food and culture on atoll and mountainous islands of Micronesia. There are many Cyrtosperma cultivars, but few have been analyzed for nutrient content. Samples were collected in the Federated States of Micronesia (Pohnpei, Chuuk and Yap) and the Republic of Palau, assessed for corm flesh color and other attributes, and analyzed for carotenoids (β- and α-carotene, β-cryptoxanthin, lutein, zeaxanthin, and lycopene) and minerals (including iron, zinc, and calcium). Of 34 cultivars analyzed, β-carotene concentrations varied from 50 to 4486μg/100g. Yellow-fleshed cultivars generally contained higher carotenoid concentrations. Of the ten cultivars analyzed for mineral content (wet weight basis), substantial concentrations of zinc (5.4–46.1mg/100g), iron (0.3–0.8mg/100g) and calcium (121–305mg/100g) were found. All cultivars were acceptable for taste and production factors. These carotenoid- and mineral-rich cultivars should be considered for promotion in Micronesia and other areas for potential health benefits. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Composition
KW - PLANT varieties
KW - CALCIUM
KW - RETINOIDS
KW - Carotenoid
KW - Chronic disease
KW - Cyrtosperma merkusii
KW - Dietary change
KW - Giant swamp taro
KW - Indigenous food
KW - Micronesia
KW - Mineral
KW - Taro cultivars
KW - Vitamin A
N1 - Accession Number: 27734484; Englberger, Lois 1; Email Address: nutrition@mail.fm Schierle, Joseph 2 Kraemer, Klaus 2 Aalbersberg, William 3 Dolodolotawake, Usaia 3 Humphries, Julia 4 Graham, Robin 5 Reid, Anne P. 6 Lorens, Adelino 1,7 Albert, Kiped 1,7 Levendusky, Amy 1 Johnson, Eliaser 8 Paul, Yumiko 8 Sengebau, Fernando 9; Affiliation: 1: Island Food Community of Pohnpei, Kolonia, Pohnpei, Federated States of Micronesia 2: DSM Nutritional Products Ltd, Kaiseraugst, Switzerland 3: Institute of Applied Science, University of the South Pacific, Suva, Fiji 4: School of Pharmacology, Flinders Medical Centre, Bedford Park, South Australia, Australia 5: University of Adelaide, Faculty of Sciences, School of Agriculture and Wine, Glen Osmond, Australia 6: Atlanta Center of Nutrient Analysis, Food and Drug Administration, Atlanta, Georgia, USA 7: Pohnpei Agriculture of the Office of Economic Affairs, Kolonia, Pohnpei, Federated States of Micronesia 8: Pohnpei Department of Health, Kolonia, Pohnpei, Federated States of Micronesia 9: Department of Agriculture, Koror, Republic of Palau, Palau; Source Info: Mar2008, Vol. 21 Issue 2, p93; Subject Term: FOOD -- Composition; Subject Term: PLANT varieties; Subject Term: CALCIUM; Subject Term: RETINOIDS; Author-Supplied Keyword: Carotenoid; Author-Supplied Keyword: Chronic disease; Author-Supplied Keyword: Cyrtosperma merkusii; Author-Supplied Keyword: Dietary change; Author-Supplied Keyword: Giant swamp taro; Author-Supplied Keyword: Indigenous food; Author-Supplied Keyword: Micronesia; Author-Supplied Keyword: Mineral; Author-Supplied Keyword: Taro cultivars; Author-Supplied Keyword: Vitamin A; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jfca.2007.09.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Garber, Eric A. E.
T1 - Detection of Melamine Using Commercial Enzyme-Linked Immunosorbent Assay Technology.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/03//
VL - 71
IS - 3
M3 - Article
SP - 590
EP - 594
SN - 0362028X
AB - Recent cases of adulteration with melamine have led to the need for rapid and reliable screening methods. To meet this need, commercial enzyme-linked immunosorbent assay (ELISA) test kits for the detection of triazines were evaluated. The recently released Melamine Plate kit (Abraxis, Warminster, Pa.) displayed a limit of detection of 9 ng/ml for melamine in phosphate-buffered saline (PBS) and approximately 1 µg/ml for melamine added to dog food. An atrazine ELISA test kit produced by Abraxis required 0.2 mg/ml to generate a response more than four times the standard deviation from background. In contrast, with the EnviroGard Triazine Plate kit (Strategic Diagnostics, Inc., Newark, Del.), 1.5 mg/ml melamine in PBS generated a signal only one standard deviation from background, which was insufficient to define a limit of detection. Extraction based on dilution with 105 mM sodium phosphate/75 mM NaC1/2.5% nonfat milk/0.05% Tween 20 (UD) enabled detection of fivefold less melamine in dog food than did use of the procedure recommended by the manufacturer, which entailed extraction into 60% methanol, sonication, centrifugation, filtration, and further dilution into 10% methanol/PBS. Using the Abraxis Melamine ELISA, both extraction protocols yielded identical results with a dog food sample adulterated with melamine. The recovery of melamine spiked into gravy from dog food using UD was 74% ± 4%. In conclusion, the recently released Abraxis ELISA for melamine proved to be a useful alternative to more cumbersome methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD adulteration & inspection
KW - FOOD contamination
KW - ENZYME-linked immunosorbent assay
KW - TRIAZINES
KW - DOGS -- Food
N1 - Accession Number: 31454395; Garber, Eric A. E. 1; Email Address: eric.garber@fda.hhs.gov; Affiliation: 1: Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Source Info: Mar2008, Vol. 71 Issue 3, p590; Subject Term: FOOD adulteration & inspection; Subject Term: FOOD contamination; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: TRIAZINES; Subject Term: DOGS -- Food; NAICS/Industry Codes: 311111 Dog and Cat Food Manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 5p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Incidence of Long-term Disability Following Traumatic Brain Injury Hospitalization, United States, 2003.
AU - Selassie, Anbesaw W.
AU - Zaloshnja, Eduard
AU - Langlois, Jean A.
AU - Miller, Ted
AU - Jones, Paul
AU - Steiner, Claudia
JO - Journal of Head Trauma Rehabilitation
JF - Journal of Head Trauma Rehabilitation
Y1 - 2008/03//Mar/Apr2008
VL - 23
IS - 2
SP - 123
EP - 131
SN - 08859701
N1 - Accession Number: 31620023; Author: Selassie, Anbesaw W.: 1 Author: Zaloshnja, Eduard: 2 email: zaloshnja@pie.org. Author: Langlois, Jean A.: 3 Author: Miller, Ted: 2 Author: Jones, Paul: 2 Author: Steiner, Claudia: 4 ; Author Affiliation: 1 Medical University of South Carolina, Charleston: 2 Pacific Institute for Research and Evaluation, Calverton, Md: 3 Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta, Ga: 4 Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Md; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20150711
N2 - Objective: Develop and validate a predictive model of the incidence of long-term disability following traumatic brain injury (TBI) and obtain national estimates for the United States in 2003. Data/methods: A logistic regression model was built, using a population-based sample of persons with TBI from the South Carolina Traumatic Brain Injury Follow-up Registry. The regression coefficients were applied to the 2003 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample data to estimate the incidence of long-term disability following traumatic brain injury hospitalization. Results: Among 288,009 (95% CI, 287,974-288,043) hospitalized TBI survivors in the United States in 2003, an estimated 124,626 (95% CI, 123,706-125,546) had developed long-term disability. Conclusion: TBI-related disability is a significant public health problem in the United States. The substantial incidence suggests the need for comprehensive rehabilitative care and services to maximize the potential of persons with TBI. ABSTRACT FROM AUTHOR
KW - *BRAIN -- Wounds & injuries
KW - *MEDICAL care costs
KW - *MEDICAL care
KW - *HOSPITAL care
KW - *PUBLIC health
KW - long-term disability
KW - traumatic brain injury
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 105914029
T1 - Board engagement in quality: findings of a survey of hospital and system leaders.
AU - Jiang HJ
AU - Lockee C
AU - Bass K
AU - Fraser I
Y1 - 2008/03//Mar/Apr2008
N1 - Accession Number: 105914029. Language: English. Entry Date: 20080516. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Kiely R. Practitioner application. (J HEALTHC MANAGE) Mar/Apr2008; 53 (2): 135-135. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. Instrumentation: Inpatient Quality Indicators (IQI) (Agency for Healthcare Research and Quality, AHRQ). NLM UID: 9803529.
KW - Governing Board
KW - Hospitals -- Evaluation
KW - Quality of Health Care -- Evaluation
KW - Bivariate Statistics
KW - Checklists
KW - Chi Square Test
KW - Clinical Indicators
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - P-Value
KW - Summated Rating Scaling
KW - Survey Research
KW - T-Tests
KW - Human
SP - 121
EP - 134
JO - Journal of Healthcare Management
JF - Journal of Healthcare Management
JA - J HEALTHC MANAGE
VL - 53
IS - 2
CY - Chicago, Illinois
PB - American College of Healthcare Executives
SN - 1096-9012
AD - Senior social scientist, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD; joanna.jiang@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Maiden, Martin C. J.
AU - Lbarz-Pavón, Ana Belén
AU - Urwin, Rachel
AU - Gray, Stephen J.
AU - Andrews, Nicholas J.
AU - Clarke, Stuart C.
AU - Walker, A. Mark
AU - Evans, Meirion R.
AU - Kroll, J. Simon
AU - Neal, Keith R.
AU - Ala'Aldeen, Dlawer A. A.
AU - Crook, Derrick W.
AU - Cann, Kathryn
AU - Harrison, Sarah
AU - Cunningham, Richard
AU - Baxter, David
AU - Kaczmarski, Edward
AU - MacLennan, Jenny
AU - Cameron, J. Claire
AU - Stuart, James M.
T1 - Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd Immunity.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/03//3/1/2008
VL - 197
IS - 5
M3 - Article
SP - 737
EP - 743
SN - 00221899
AB - Background. In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced in the United Kingdom for those under 19 years of age. The impact of this intervention on asymptomatic carriage of meningococci was investigated to establish whether serogroup replacement or protection by herd immunity occurred. Methods. Multicenter surveys of carriage were conducted during vaccine introduction and on 2 successive years, resulting in a total of 48,309 samples, from which 8599 meningococci were isolated and characterized by genotyping and phenotyping. Results. A reduction in serogroup C carriage (rate ratio, 0.19) was observed that lasted at least 2 years with no evidence of serogroup replacement. Vaccine efficacy against carriage was 75%, and vaccination had a disproportion- ate impact on the carriage of sequence type (ST)-11 complex serogroup C meningococci that (rate ratio, 0.06); these meningococci also exhibited high rates of capsule expression. Conclusions. The impact of vaccination with MCC vaccine on the prevalence of carriage of group C meningococci was consistent with herd immunity. The high impact on the carriage of ST-11 complex serogroup C could be attributed to high levels of capsule expression. High vaccine efficacy against disease in young children, who were not protected long-term by the schedule initially used, is attributed to the high vaccine efficacy against carriage in older age groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CEREBROSPINAL meningitis -- Vaccination
KW - PREVENTIVE medicine
KW - VACCINES
KW - COMMUNICABLE diseases -- Prevention
KW - IMMUNIZATION of children
KW - THERAPEUTIC use
KW - GREAT Britain
N1 - Accession Number: 31661058; Maiden, Martin C. J. 1; Email Address: martinmaiden@zoo.ox.ac.uk Lbarz-Pavón, Ana Belén 1 Urwin, Rachel 1 Gray, Stephen J. 2 Andrews, Nicholas J. 3 Clarke, Stuart C. 4 Walker, A. Mark 5 Evans, Meirion R. 6 Kroll, J. Simon 7 Neal, Keith R. 8 Ala'Aldeen, Dlawer A. A. 9 Crook, Derrick W. 10 Cann, Kathryn 10 Harrison, Sarah 11 Cunningham, Richard 12 Baxter, David 13 Kaczmarski, Edward 14 MacLennan, Jenny 1 Cameron, J. Claire 15 Stuart, James M. 16; Affiliation: 1: Dept. of Zoology , John Radcliffe Hospital, Oxford University, Oxford 2: Meningococcal Reference Unit, Health Protection Agency, Manchester Medical Microbiology Partnership 3: Health Protection Agency Centre for Infections 4: Molecular Microbiology Group, School of Medicine, University of Southampton 5: University of Wales, Bangor, Gwynedd 6: National Public Health Service for Wales, Unit 1, Parc Nantgarw, Cardiff 7: lmperial College School of Medicine, London 8: University of Nottingham, Epidemiology and Public Health, Community Health Sciences, Queen's Medical Centre, Nottingham 9: Division of Microbiology, School of Molecular Medical Sciences, Institute of Infection Immunity and Inflammation University of Nottingham 10: Nuffield Dept. of Clinical and Laboratory Sciences, John Radcliffe Hospital, Oxford University, Oxford 11: South West Peninsula Health Protection Unit, Lescaze Offices, Dartington, Devon 12: Derriford Hospital, Crownhill, Plymouth, Devon 13: Div. of Epidemiology and Health Sciences, Medical School, the University of Manchester, Manchester 14: Clinical Science Building, Manchester Royal Infirmary 15: Health Protection Scotland, Clifton House, Glasgow, Scotland 16: Health Protection Agency South West, Stonehouse, Gloucester, United Kingdom; Source Info: 3/1/2008, Vol. 197 Issue 5, p737; Subject Term: CEREBROSPINAL meningitis -- Vaccination; Subject Term: PREVENTIVE medicine; Subject Term: VACCINES; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: IMMUNIZATION of children; Subject Term: THERAPEUTIC use; Subject Term: GREAT Britain; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1086/527401
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Soon-Tae
AU - Chu, Kon
AU - Park, Jung-Eun
AU - Hong, Nan Hyung
AU - Im, Woo-Seok
AU - Kang, Lami
AU - Han, Zhe
AU - Jung, Keun-Hwa
AU - Kim, Min-Wook
AU - Kim, Manho
T1 - Atorvastatin attenuates mitochondrial toxin-induced striatal degeneration, with decreasing iNOS/c-Jun levels and activating ERK/Akt pathways.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2008/03//
VL - 104
IS - 5
M3 - Article
SP - 1190
EP - 1200
PB - Wiley-Blackwell
SN - 00223042
AB - Mitochondrial dysfunction is a major contributor to neurodegeneration, and causes vulnerability to oxidative stress and the activations of downstream cell death pathways. 3-Hydroxy-3-methyl-glutaryl-CoA reductase inhibitors, statins, were originally developed as cholesterol lowering agents, and have cholesterol-independent anti-excitotoxic and anti-oxidative properties. We investigated whether atorvastatin can prevent the neurodegeneration induced by a mitochondrial toxin, 3-nitropropionic acid (3NP), which inhibits succinate dehydrogenase complex II. Male Lewis rats were administered 3NP (63 mg/kg/day) using osmotic pumps for 5 days to induce striatal degeneration, and were also treated with either atorvastatin (1 or 10 mg/kg/day, orally) or vehicle (control) on five consecutive days. Atorvastatin-treated rats showed fewer neurologic deficits than control animals as measured at day 3–5. Atorvastatin-treated animals showed reduced striatal lesion volumes by Nissl staining, and decreased numbers of TUNEL-positive apoptosis and Fluoro-Jade C-positive degenerating neurons at 5 days. Atorvastatin reduced the numbers of c-Jun-positive and p-c-Jun-positive cells, as well as 3-nitrotyrosin-positive cells. In addition, atorvastatin increased p -extracellular signal-regulated kinase and p-Akt levels, and attenuated the up-regulation of inducible nitric oxide synthase by 3NP. When N(omega)-nitro-l-arginine methyl ester hydrochloride was administered concomitantly with the 3NP infusion, atorvastatin failed to further reduce the striatal lesion volume and c-Jun levels compared to the vehicle treatment. In summary, atorvastatin decreased striatal neurodegeneration induced by 3NP, with attenuating inducible nitric oxide synthase and c-Jun levels as well as activating extracellular signal-regulated kinase and Akt. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL death
KW - STATINS (Cardiovascular agents)
KW - CHOLESTEROL
KW - NITRIC oxide
KW - ANTICHOLESTEREMIC agents
KW - ANIMAL experimentation
KW - 3-nitropropionic acid
KW - atorvastatin
KW - Huntington’s disease
KW - Huntington's disease
KW - mitochondria
KW - neurodegeneration
N1 - Accession Number: 29412353; Lee, Soon-Tae 1,2,3 Chu, Kon 4,5 Park, Jung-Eun 1 Hong, Nan Hyung 1 Im, Woo-Seok 1 Kang, Lami 1 Han, Zhe 1 Jung, Keun-Hwa Kim, Min-Wook 2 Kim, Manho; Email Address: kimmanho@snu.ac.kr; Affiliation: 1: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea 2: Department of Rehabilitation Medicine, Our Lady of Mercy Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea 3: Program in Public Health Service, Seoul National Hospital, Seoul, South Korea 4: Division of Epidemic Intelligence Service, Korea Center for Disease Control & Prevention, Seoul, South Korea 5: Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, South K; Source Info: Mar2008, Vol. 104 Issue 5, p1190; Subject Term: CELL death; Subject Term: STATINS (Cardiovascular agents); Subject Term: CHOLESTEROL; Subject Term: NITRIC oxide; Subject Term: ANTICHOLESTEREMIC agents; Subject Term: ANIMAL experimentation; Author-Supplied Keyword: 3-nitropropionic acid; Author-Supplied Keyword: atorvastatin; Author-Supplied Keyword: Huntington’s disease; Author-Supplied Keyword: Huntington's disease; Author-Supplied Keyword: mitochondria; Author-Supplied Keyword: neurodegeneration; Number of Pages: 11p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1111/j.1471-4159.2007.05044.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Biagini, Raymond E.
AU - Smith, Jerry P.
AU - Sammons, Deborah L.
AU - MacKenzie, Barbara A.
AU - Striley, Cynthia A. F.
AU - Robertson, Shirley K.
AU - Snawder, John E.
T1 - Analytical Performance Criteria.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/03//
VL - 5
IS - 3
M3 - Article
SP - 37
EP - 42
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article focuses on the use of immunochemical and biosensor methods for occupational and environmental monitoring. It is noted that by adding purified analyte to the matrix that is going to be used in the analysis, standard curves for enzyme-linked immunosorbent assays (ELISAs) are normally prepared. It is stated that quartz crystal resonator, consisting of a disk with electrodes plated on its surface is the basis of piezoelectric immunobiosensors.
KW - Industrial safety
KW - Environmental monitoring
KW - Industrial hygiene
KW - Enzyme-linked immunosorbent assay
KW - Detectors
N1 - Accession Number: 75127809; Ashley, Kevin; Biagini, Raymond E. 1; Smith, Jerry P. 1; Sammons, Deborah L. 1; MacKenzie, Barbara A. 1; Striley, Cynthia A. F. 1; Robertson, Shirley K. 1; Snawder, John E. 1; Affiliations: 1: Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Issue Info: Mar2008, Vol. 5 Issue 3, p37; Thesaurus Term: Industrial safety; Thesaurus Term: Environmental monitoring; Thesaurus Term: Industrial hygiene; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Detectors; NAICS/Industry Codes: 541620 Environmental Consulting Services; Number of Pages: 6p; Document Type: Article
L3 - 10.1080/15459620701798224
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Byrne, David C.
AU - Reeves, Efrem R.
T1 - Analysis of Nonstandard Noise Dosimeter Microphone Positions.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/03//
VL - 5
IS - 3
M3 - Article
SP - 197
EP - 209
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study was conducted as part of a project involving the evaluation of a new type of noise exposure monitoring paradigm. Laboratory tests were conducted to assess how "nonstandard" dosimeter microphones and microphone positions measured noise levels under different acoustical conditions (i.e., diffuse field and direct field). The data presented in this article reflect measurement differences due to microphone position and mounting/supporting structure only and are not an evaluation of any particular complete dosimeter system. To varying degrees, the results obtained with the dosimeter microphones used in this study differed from the reference results obtained in the unperturbed (subject absent) sound field with a precision (suitable for use in an ANSI Type 1 sound level meter) 1/2-inch (12.7 mm) measurement microphone. Effects of dosimeter microphone placement in a diffuse field were found to be minor for most of the test microphones/locations, while direct field microphone placement effects were found to be quite large depending on the microphone position and supporting structure, sound source location, and noise spectrum. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Noise pollution
KW - Industrial hygiene
KW - Dosimeters
KW - Occupational training
KW - dosimeter
KW - microphone
KW - noise
N1 - Accession Number: 75127811; Byrne, David C. 1; Reeves, Efrem R. 2; Affiliations: 1: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: United States Army Aeromedical Research Laboratory, Fort Rucker, Alabama; Issue Info: Mar2008, Vol. 5 Issue 3, p197; Thesaurus Term: Industrial safety; Thesaurus Term: Noise pollution; Thesaurus Term: Industrial hygiene; Subject Term: Dosimeters; Subject Term: Occupational training; Author-Supplied Keyword: dosimeter; Author-Supplied Keyword: microphone; Author-Supplied Keyword: noise; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/15459620701879438
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105725782
T1 - Analysis of nonstandard noise dosimeter microphone positions.
AU - Byrne DC
AU - Reeves ER
Y1 - 2008/03//
N1 - Accession Number: 105725782. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Acoustics -- Equipment and Supplies
KW - Noise
KW - Occupational Exposure -- Analysis
KW - Adult
KW - Female
KW - Male
KW - Middle Age
KW - Pennsylvania
KW - Sound
KW - Human
SP - 197
EP - 209
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study was conducted as part of a project involving the evaluation of a new type of noise exposure monitoring paradigm. Laboratory tests were conducted to assess how 'nonstandard' dosimeter microphones and microphone positions measured noise levels under different acoustical conditions (i.e., diffuse field and direct field). The data presented in this article reflect measurement differences due to microphone position and mounting/supporting structure only and are not an evaluation of any particular complete dosimeter system. To varying degrees, the results obtained with the dosimeter microphones used in this study differed from the reference results obtained in the unperturbed (subject absent) sound field with a precision (suitable for use in an ANSI Type 1 sound level meter) (1)/(2)-inch (12.7 mm) measurement microphone. Effects of dosimeter microphone placement in a diffuse field were found to be minor for most of the test microphones/locations, while direct field microphone placement effects were found to be quite large depending on the microphone position and supporting structure, sound source location, and noise spectrum.
SN - 1545-9624
AD - Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
U2 - PMID: 18213533.
DO - 10.1080/15459620701879438
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109849018
T1 - Invited commentary. Forging a new path to medication safety with emergency pharmacists.
AU - Clancy CM
Y1 - 2008/03//2008 Mar
N1 - Accession Number: 109849018. Language: English. Entry Date: 20080502. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Emergency Care; Patient Safety. NLM UID: 101233393.
KW - Adverse Drug Event -- Prevention and Control
KW - Emergency Service
KW - Patient Safety
KW - Pharmacists
KW - Inpatients
KW - Job Description
KW - Program Implementation
KW - Specialization
SP - 1
EP - 2
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 4
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; SPrasad@AHRQ.GOV; cclancy@ahrq.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, Douglas C.
AU - Muck, Randolph D.
T1 - SAMHSA's Strengthening Communities for Youth (SCY) Initiative. (Cover story)
JO - Journal of Psychoactive Drugs
JF - Journal of Psychoactive Drugs
Y1 - 2008/03//
VL - 40
IS - 1
M3 - Article
SP - 1
EP - 2
PB - Routledge
SN - 02791072
AB - The article discusses various reports published within the issue including one on an overview of the Strengthening Communities for Youth (SCY) project's goals and another on the costs and outcomes of substance abuse treatments provided to adolescents in the juvenile system.
KW - SUBSTANCE abuse
KW - JUVENILE justice administration
N1 - Accession Number: 32759252; Smith, Douglas C. 1; Email Address: douglas-c-smith@uiowa.edu Muck, Randolph D. 2; Affiliation: 1: Assistant Research Scientist, Department of Pediatrics, University of Iowa 2: Chief, Targeted Populations Branch, Division of Services Improvement, Center for Substance Abuse Treatment; Source Info: Mar2008, Vol. 40 Issue 1, p1; Subject Term: SUBSTANCE abuse; Subject Term: JUVENILE justice administration; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hariharan, Prasanna
AU - Myers, Matthew R.
AU - Robinson, Ronald A.
AU - Maruvada, Subha H.
AU - Sliwa, Jack
AU - Banerjee, Rupak K.
T1 - Characterization of high intensity focused ultrasound transducers using acoustic streaming.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/03//
VL - 123
IS - 3
M3 - Article
SP - 1706
EP - 1719
SN - 00014966
AB - A new approach for characterizing high intensity focused ultrasound (HIFU) transducers is presented. The technique is based upon the acoustic streaming field generated by absorption of the HIFU beam in a liquid medium. The streaming field is quantified using digital particle image velocimetry, and a numerical algorithm is employed to compute the acoustic intensity field giving rise to the observed streaming field. The method as presented here is applicable to moderate intensity regimes, above the intensities which may be damaging to conventional hydrophones, but below the levels where nonlinear propagation effects are appreciable. Intensity fields and acoustic powers predicted using the streaming method were found to agree within 10% with measurements obtained using hydrophones and radiation force balances. Besides acoustic intensity fields, the streaming technique may be used to determine other important HIFU parameters, such as beam tilt angle or absorption of the propagation medium. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH-intensity focused ultrasound
KW - TRANSDUCERS
KW - ACOUSTIC streaming
KW - PARTICLE image velocimetry
KW - COMPUTER algorithms
KW - HYDROPHONE
KW - ACOUSTIC intensity method
N1 - Accession Number: 31229830; Hariharan, Prasanna 1,2 Myers, Matthew R. 1; Email Address: matthew.myers@fda.hhs.gov Robinson, Ronald A. 1 Maruvada, Subha H. 1 Sliwa, Jack 3 Banerjee, Rupak K. 4; Affiliation: 1: Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, U. S. Food and Drug Administration, Silver Spring, Maryland 20993, USA 2: Mechanical, Industrial, and Nuclear Engineering Department, University of Cincinnati, Cincinnati, Ohio 45221, USA 3: St. Jude Medical, AF Division, 240 Santa Ana Court, Sunnyvale, California 94085, USA 4: Mechanical, Industrial and Nuclear Engineering Department and Biomedical Engineering Department, 598 Rhodes Hall, P.O. Box 210072, University of Cincinnati, Cincinnati, Ohio 45221, USA; Source Info: Mar2008, Vol. 123 Issue 3, p1706; Subject Term: HIGH-intensity focused ultrasound; Subject Term: TRANSDUCERS; Subject Term: ACOUSTIC streaming; Subject Term: PARTICLE image velocimetry; Subject Term: COMPUTER algorithms; Subject Term: HYDROPHONE; Subject Term: ACOUSTIC intensity method; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; Number of Pages: 14p; Illustrations: 4 Diagrams, 2 Charts, 9 Graphs; Document Type: Article
L3 - 10.1121/1.2835662
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105797760
T1 - Sex and race differences in mental health symptoms in juvenile justice: the MAYSI-2 national meta-analysis.
AU - Vincent GM
AU - Grisso T
AU - Terry A
AU - Banks S
Y1 - 2008/03//
N1 - Accession Number: 105797760. Language: English. Entry Date: 20080822. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care; Psychiatry/Psychology. NLM UID: 8704565.
KW - Juvenile Delinquency -- Psychosocial Factors
KW - Mental Disorders -- Epidemiology
KW - Prisoners -- Psychosocial Factors
KW - Adolescence
KW - Demography
KW - Ethnic Groups -- Psychosocial Factors
KW - Female
KW - Juvenile Delinquency -- Ethnology
KW - Male
KW - Mental Disorders -- Ethnology
KW - Prevalence
KW - Risk Factors
KW - United States
KW - Human
SP - 282
EP - 290
JO - Journal of the American Academy of Child & Adolescent Psychiatry
JF - Journal of the American Academy of Child & Adolescent Psychiatry
JA - J AM ACAD CHILD ADOLESC PSYCHIATRY
VL - 47
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0890-8567
AD - Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA 01655, USA. gina.vincent@umassmed.edu
U2 - PMID: 18216730.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Chang-Soo
AU - Massa, Ted R.
AU - Rohrer, Gregory S.
T1 - Interface Character Distributions in WC–Co Composites.
JO - Journal of the American Ceramic Society
JF - Journal of the American Ceramic Society
Y1 - 2008/03//
VL - 91
IS - 3
M3 - Article
SP - 996
EP - 1001
PB - Wiley-Blackwell
SN - 00027820
AB - The geometric and crystallographic characteristics of interfaces in WC–Co composites with a range of grain sizes and carbide volume fractions have been comprehensively characterized. The carbide crystals are most frequently terminated by (0001) and surfaces. The average number of carbide vertices per grain and the basal-to-prismatic face area ratio of the WC–Co interfaces increase with the carbide volume fraction. The three most frequently occurring WC/WC grain boundaries are 90° twist boundaries about , 30° twist boundaries about [0001], and asymmetric 90° boundaries about . The boundary populations do not vary with grain size or carbide volume fraction, suggesting that they are determined by the grain boundary energy anisotropy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Ceramic Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPOSITE materials
KW - CRYSTALLOGRAPHY
KW - SURFACE chemistry
KW - CRYSTALS
KW - CARBIDES
KW - CRYSTAL grain boundaries
KW - ASYMMETRY (Chemistry)
KW - ANISOTROPY
KW - MATERIALS science
N1 - Accession Number: 31180662; Kim, Chang-Soo 1,2 Massa, Ted R. 3 Rohrer, Gregory S. 1; Email Address: gr20@andrew.cmu.edu; Affiliation: 1: Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 2: Division of Chemistry and Materials Science, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA 3: Corporate Technology, Kennametal Incorporated, Latrobe, Pennsylvania 15650; Source Info: Mar2008, Vol. 91 Issue 3, p996; Subject Term: COMPOSITE materials; Subject Term: CRYSTALLOGRAPHY; Subject Term: SURFACE chemistry; Subject Term: CRYSTALS; Subject Term: CARBIDES; Subject Term: CRYSTAL grain boundaries; Subject Term: ASYMMETRY (Chemistry); Subject Term: ANISOTROPY; Subject Term: MATERIALS science; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1111/j.1551-2916.2007.02226.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chattopaduyay, Somesh
AU - Hammerstrom, Thomas
T1 - Statistical Monitoring of Clinical Trials: A Unified Approach.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2008/03//
VL - 103
IS - 481
M3 - Book Review
SP - 430
EP - 431
SN - 01621459
AB - The article reviews the book "Statistical Monitoring of Clinical Trials: A Unified Approach," by Michael A. Proschan, K. K. Gordon Lan and Janet Turk Wittes.
KW - CLINICAL trials
KW - NONFICTION
KW - LAN, K. K. Gordon
KW - WITTES, Janet Turk
KW - PROSCHAN, Michael A.
KW - STATISTICAL Monitoring of Clinical Trials (Book)
N1 - Accession Number: 31597041; Chattopaduyay, Somesh 1; Hammerstrom, Thomas 1; Affiliations: 1: Food and Drug Administration; Issue Info: Mar2008, Vol. 103 Issue 481, p430; Subject Term: CLINICAL trials; Subject Term: NONFICTION; Reviews & Products: STATISTICAL Monitoring of Clinical Trials (Book); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: LAN, K. K. Gordon; People: WITTES, Janet Turk; People: PROSCHAN, Michael A.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Weston, Ainsley
T1 - Application of Oligonucleotide Microarray Technology to Toxic Occupational Exposures.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/03//
VL - 71
IS - 5
M3 - Article
SP - 315
EP - 324
SN - 15287394
AB - Microarray technology has advanced toward analysis of toxic occupational exposures in biological systems. Microarray analysis is an ideal way to search for biomarkers of exposure, even if no specific gene or pathway has been identified. Analysis may now be performed on thousands of genes simultaneously, as opposed to small numbers of genes as in the past. This ability has been put to use to analyze gene expression profiles of a variety of occupational toxins in animal models to classify toxins into specific categories based on response. Analysis of normal human cell strains allows an extension of this analysis to investigate the role of interindividual variation in response to various toxins. This methodology was used to analyze four occupationally related toxins in our lab: oxythioquinox (OTQ), a quinoxaline pesticide; malathion, an organophosphate pesticide; di-n-butyl phthalate (DBP), a chemical commonly found in personal care and cosmetic items; and benzo[a]pyrene (BaP), an environmental and occupational carcinogen. The results for each exposure highlighted signaling pathways involved in response to these occupational exposures. Both pesticides showed increase in metabolic enzymes, while DBP showed alterations in genes related to fertility. BaP exposure showed alterations in two cytochrome P450s related to carcinogenicity. When used with occupational exposure information, these data may be used to augment risk assessment to make the workplace safer for a greater proportion of the workforce, including individuals susceptible to disease related to exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLIGONUCLEOTIDES
KW - BIOCHEMICAL markers
KW - INDUSTRIAL toxicology
KW - TOXINS
KW - QUINOXALINES
KW - MALATHION
KW - CARCINOGENESIS
KW - METABOLITES
KW - CHOLINESTERASE-inhibiting insecticides
KW - ORGANOPHOSPHORUS compounds
N1 - Accession Number: 28605192; Gwinn, Maureen R. 1 Weston, Ainsley 2; Email Address: agw8@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, USA 2: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Mar2008, Vol. 71 Issue 5, p315; Subject Term: OLIGONUCLEOTIDES; Subject Term: BIOCHEMICAL markers; Subject Term: INDUSTRIAL toxicology; Subject Term: TOXINS; Subject Term: QUINOXALINES; Subject Term: MALATHION; Subject Term: CARCINOGENESIS; Subject Term: METABOLITES; Subject Term: CHOLINESTERASE-inhibiting insecticides; Subject Term: ORGANOPHOSPHORUS compounds; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Illustrations: 1 Color Photograph, 4 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15287390701738509
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sapsford, Kim E.
AU - Bradburne, Christopher
AU - Delehanty, James B.
AU - Medintz, Igor L.
T1 - Sensors for detecting biological agents
JO - Materials Today
JF - Materials Today
Y1 - 2008/03//
VL - 11
IS - 3
M3 - Article
SP - 38
EP - 49
SN - 13697021
AB - Biological agents including viruses, bacteria, and other naturally occurring pathogenic organisms, along with the toxins they produce, are considered far harder to detect and defend against than chemical agents. Here we provide an overview of the predominant molecular sensing technologies for the detection of these agents. This includes biosensing strategies based upon use of antibodies, genomic analysis, biochemical testing, other recognition interactions, and cellular-based responses. We survey some popular sensing approaches, illustrate them with current examples showing how they have been applied, and discuss their intrinsic benefits and potential liabilities. Lastly, within the context of security applications, some approaches for integrating sensing technologies into field-portable devices are discussed. [Copyright &y& Elsevier]
AB - Copyright of Materials Today is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - BIOLOGICAL weapons
KW - CHEMICAL weapons
KW - DETECTORS
KW - IMMUNOGLOBULINS
N1 - Accession Number: 30016365; Sapsford, Kim E. 1 Bradburne, Christopher 2 Delehanty, James B. 2 Medintz, Igor L. 2; Email Address: Igor.Medintz@nrl.navy.mil; Affiliation: 1: Division of Biology, Office of Science and Engineering Laboratories, US Food and Drug Administration, 10993 New Hampshire Ave., Silver Spring, MD 20903, USA 2: Center for Bio/Molecular Science and Engineering Code 6900, US Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375, USA; Source Info: Mar2008, Vol. 11 Issue 3, p38; Subject Term: BIOSENSORS; Subject Term: BIOLOGICAL weapons; Subject Term: CHEMICAL weapons; Subject Term: DETECTORS; Subject Term: IMMUNOGLOBULINS; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/S1369-7021(08)70018-X
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marble, William Sanders
T1 - Medical Support for Pershing's Punitive Expedition in Mexico, 1916-1917.
JO - Military Medicine
JF - Military Medicine
Y1 - 2008/03//
VL - 173
IS - 3
M3 - Article
SP - 287
EP - 292
PB - AMSUS
SN - 00264075
AB - Pershing's Punitive Expedition had adequate medical support despite deliberately limited in-theater resources. The few casualties did not strain the inadequate number of forward providers. Preventive medicine was highly successful due to significant medical and command emphasis. New technologies were useful and helped minimize the medical footprint. National Guard troops mobilized to support the Expedition had troublesome medical readiness rates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HISTORY
KW - PREVENTIVE medicine
KW - MILITARY medicine
KW - UNITED States. Army
KW - PUNITIVE Expedition into Mexico, 1916
KW - UNITED States
KW - MEXICO
KW - UNITED States. Army -- History -- Punitive Expedition into Mexico, 1916
N1 - Accession Number: 31609790; Marble, William Sanders 1; Affiliation: 1: Office of Medical History, Office of the Surgeon General, U.S. Army, 5111 Leesburg Pike, Suite 401B, Falls Church, VA 22041; Source Info: Mar2008, Vol. 173 Issue 3, p287; Subject Term: HISTORY; Subject Term: PREVENTIVE medicine; Subject Term: MILITARY medicine; Subject Term: UNITED States. Army; Subject Term: PUNITIVE Expedition into Mexico, 1916; Subject Term: UNITED States; Subject Term: MEXICO; Company/Entity: UNITED States. Army -- History -- Punitive Expedition into Mexico, 1916; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105725865
T1 - Medical support for Pershing's punitive expedition in Mexico, 1916-1917.
AU - Marble WS
Y1 - 2008/03//
N1 - Accession Number: 105725865. Language: English. Entry Date: 20080523. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. NLM UID: 2984771R.
KW - Health Care Delivery -- History
KW - Military Medicine -- History
KW - Military Personnel -- History
KW - Preventive Health Care -- History
KW - War
KW - History
KW - Mexico
KW - Military Medicine
KW - United States
SP - 287
EP - 292
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 173
IS - 3
CY - Bethesda, Maryland
PB - AMSUS
AB - Pershing's Punitive Expedition had adequate medical support despite deliberately limited in-theater resources. The few casualties did not strain the inadequate number of forward providers. Preventive medicine was highly successful due to significant medical and command emphasis. New technologies were useful and helped minimize the medical footprint. National Guard troops mobilized to support the Expedition had troublesome medical readiness rates.
SN - 0026-4075
AD - Office of Medical History, Office of the Surgeon General, U.S. Army, 5111 Leesburg Pike, Suite 401B, Falls Church, VA 22041
U2 - PMID: 18419032.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Lee, Taewon
AU - Delongchamp, Robert R.
AU - Leakey, Julian E.A.
AU - Lewis, Sherry M.
AU - Lee, Fei
AU - Moland, Carrie L.
AU - Branham, William S.
AU - Fuscoe, James C.
T1 - Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2008/03//
VL - 8
IS - 2
M3 - Article
SP - 181
EP - 195
SN - 15677249
AB - Abstract: Mitochondrial dysfunction has been implicated in the adverse effects of nucleoside reverse transcriptase inhibitors (NRTIs) used to treat HIV-1 infections. To gain insight into the mechanism by which NRTIs alter mitochondrial function, the expression level of 542 genes associated with mitochondrial structure and functions was determined in the livers of p53 haplodeficient (+/−) C3B6F1 female mouse pups using mouse mitochondria-specific oligonucleotide microarray. The pups were transplacentally exposed to zidovudine (AZT) at 240mg/kg bw/day or a combination of AZT and lamivudine (3TC) at 160 and 100mg/kg bw/day, respectively, from gestation day 12 through 18, followed by continuous treatment by oral administration from postnatal day 1–28. In addition, AZT/3TC effect was investigated in wild-type (+/+) C3B6F1 female mice. The genotype did not significantly affect the gene expression profile induced by AZT/3TC treatment. However, the transcriptional level of several genes associated with oxidative phosphorylation, mitochondrial tRNAs, fatty acid oxidation, steroid biosynthesis, and a few transport proteins were significantly altered in pups treated with AZT and AZT/3TC compared to their vehicle counterparts. Interestingly, AZT/3TC altered the expression level of 153 genes with false discovery rate of less than 0.05, in contrast to only 20 genes by AZT alone. These results suggest that NRTI-related effect on expression level of genes associated with mitochondrial functions was much greater in response to AZT/3TC combination treatment than AZT alone. [Copyright &y& Elsevier]
AB - Copyright of Mitochondrion is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIA
KW - MITOCHONDRIAL pathology
KW - LIVER
KW - GENE expression
KW - MICE
KW - Microarray
KW - Mitochondria
KW - mitochondrial DNA ( mtDNA )
KW - Mouse MitoChip
KW - nuclear DNA ( nDNA )
KW - Nucleoside reverse transcriptase inhibitors
KW - nucleoside reverse transcriptase inhibitors ( NRTIs )
KW - p53 haplodeficient (+/−) C3B6F1 female mouse
KW - p53 wild-type (+/+) C3B6F1 female mouse
N1 - Accession Number: 31252944; Desai, Varsha G. 1; Email Address: varsha.desai@fda.hhs.gov Lee, Taewon 2 Delongchamp, Robert R. 3 Leakey, Julian E.A. 4 Lewis, Sherry M. 4 Lee, Fei 4 Moland, Carrie L. 1 Branham, William S. 1 Fuscoe, James C. 1; Affiliation: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of Personalized Nutrition and Medicine, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA 3: Department of Epidemiology, University of Arkansas for Medical Sciences, College of Public Health, Little Rock, AR 72205, USA 4: Office of Scientific Coordination, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Mar2008, Vol. 8 Issue 2, p181; Subject Term: MITOCHONDRIA; Subject Term: MITOCHONDRIAL pathology; Subject Term: LIVER; Subject Term: GENE expression; Subject Term: MICE; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: mitochondrial DNA ( mtDNA ); Author-Supplied Keyword: Mouse MitoChip; Author-Supplied Keyword: nuclear DNA ( nDNA ); Author-Supplied Keyword: Nucleoside reverse transcriptase inhibitors; Author-Supplied Keyword: nucleoside reverse transcriptase inhibitors ( NRTIs ); Author-Supplied Keyword: p53 haplodeficient (+/−) C3B6F1 female mouse; Author-Supplied Keyword: p53 wild-type (+/+) C3B6F1 female mouse; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.mito.2008.01.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Howard, John
T1 - The 9/11 World Trade Center Disaster: Past and Future.
JO - Mount Sinai Journal of Medicine
JF - Mount Sinai Journal of Medicine
Y1 - 2008/03//Mar/Apr2008
VL - 75
IS - 2
M3 - Article
SP - 65
EP - 66
PB - Wiley-Blackwell
SN - 00272507
AB - The author notes the unprecedented scale of the September 11, 2001 terrorist attacks and the emergency response that it evoked. He cites that some early responders developed acute respiratory conditions and in the months that followed the disaster, many responders and residents near the site experienced new or worsened aerodigestive and mental health problems. He stresses the need to focus on the scientific study of the physical and mental health impact of exposure to the World Trade Center disaster.
KW - SEPTEMBER 11 Terrorist Attacks, 2001
KW - FIRST responders
KW - RESPIRATORY diseases
KW - MENTAL health
KW - NEW York (N.Y.)
KW - NEW York (State)
KW - WORLD Trade Center (New York, N.Y. : 1970-2001)
N1 - Accession Number: 33116262; Howard, John 1,2; Email Address: jacqueline.moline@mssm.edu; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Washington, DC 2: World Trade Center Health Programs, US Department of Health and Human Services, Washington, DC; Source Info: Mar/Apr2008, Vol. 75 Issue 2, p65; Subject Term: SEPTEMBER 11 Terrorist Attacks, 2001; Subject Term: FIRST responders; Subject Term: RESPIRATORY diseases; Subject Term: MENTAL health; Subject Term: NEW York (N.Y.); Subject Term: NEW York (State); Company/Entity: WORLD Trade Center (New York, N.Y. : 1970-2001); NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 2p; Document Type: Article
L3 - 10.1002/msj.20037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reissman, Dori B.
AU - Howard, John
T1 - Responder Safety and Health: Preparing for Future Disasters.
JO - Mount Sinai Journal of Medicine
JF - Mount Sinai Journal of Medicine
Y1 - 2008/03//Mar/Apr2008
VL - 75
IS - 2
M3 - Article
SP - 135
EP - 141
PB - Wiley-Blackwell
SN - 00272507
AB - This article reviews lessons learned about managing the safety and health of workers who were involved in disaster response, recovery, and cleanup after the 2001 World Trade Center (WTC) disaster. The first two sections review ongoing responder health burdens and the tragic toll of this disaster from a worker safety and health perspective. The remaining sections address changes in federal infrastructure, response planning, and resources for protection of response and recovery personnel. Proper preparation includes pre-event and "just-in-time" disaster-worker training on likely hazards, organizational assets for hazard monitoring, and hands-on instruction in the use of assigned protective equipment. Good planning includes predeployment medical review to ensure "fitness for duty" and considers the following: (1) personal risk factors, (2) hazards likely to be associated with particular field locations, and (3) risks involved with assigned tasks (eg, workload and pace, work/rest cycles, available resources, and team/supervisory dynamics). Planning also should address worker health surveillance, medical monitoring, and availability of medical care (including mental health services). Disaster safety managers should anticipate likely hazards within planning scenarios and prepare asset inventories to facilitate making timely safety decisions. Disaster safety management begins immediately and provides ongoing real-time guidance to incident leadership at all levels of government. Robust standards must be met to reliably protect workers/responders. An integrated and measurable multiagency safety management function must be built into the incident command system before an incident occurs. This function delineates roles and responsibilities for rapid exposure assessments, ensuring cross-agency consistency in data interpretation, and timely, effective communication of information and control strategies. The ability to perform this safety management function should be tested and evaluated in exercise simulations and drills at multiple levels. Joint planning and exercising of the safety management plan and its function are effective ways to build interagency relationships and to be more systemic in managing logistics for safety equipment and converging personnel. Planning must include mechanisms to enable safety decisions to be implemented--such as effective and rapid scene control (site access), personnel tracking, and safety enforcement. Worker safety and health preparedness and leadership are essential for protecting workers and promoting resiliency among personnel involved in disaster response, recovery, and cleanup. [ABSTRACT FROM AUTHOR]
AB - Copyright of Mount Sinai Journal of Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VOLUNTEERS -- Health
KW - FIRST responders
KW - DISASTER relief
KW - SEPTEMBER 11 Terrorist Attacks, 2001
KW - TERRORISM
KW - MEDICAL care -- United States
KW - EMERGENCY management
KW - UNITED States
KW - disaster-safety management
KW - disaster-worker health
KW - responder health
KW - responder safety
KW - worker safety
N1 - Accession Number: 33116270; Reissman, Dori B. 1; Email Address: DReissman@cdc.gov Howard, John 1; Affiliation: 1: National Institute for Occupational Safety and Health, Washington, D.C., USA; Source Info: Mar/Apr2008, Vol. 75 Issue 2, p135; Subject Term: VOLUNTEERS -- Health; Subject Term: FIRST responders; Subject Term: DISASTER relief; Subject Term: SEPTEMBER 11 Terrorist Attacks, 2001; Subject Term: TERRORISM; Subject Term: MEDICAL care -- United States; Subject Term: EMERGENCY management; Subject Term: UNITED States; Author-Supplied Keyword: disaster-safety management; Author-Supplied Keyword: disaster-worker health; Author-Supplied Keyword: responder health; Author-Supplied Keyword: responder safety; Author-Supplied Keyword: worker safety; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/msj.20024
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - PAPP, THILO
AU - SCHIFFMANN, DIETMAR
AU - WEISS, DIETER
AU - CASTRANOVA, VINCE
AU - VALLYATHAN, VAL
AU - RAHMAN, QAMAR
T1 - Human health implications of nanomaterial exposure.
JO - Nanotoxicology
JF - Nanotoxicology
Y1 - 2008/03//
VL - 2
IS - 1
M3 - Article
SP - 9
EP - 27
SN - 17435390
AB - Nanotechnology presents countless opportunities to develop new and improved consumer products for the benefit of society. However, as the industrial production and use of nanotechnology products continue to expand at a fast scale, potential human health concerns and ecological safeguards for the environment need to be addressed. Health risk assessment involving different animal species for multi-organ toxicity complimented with molecular investigations in cells is essential for investigating the potential toxic effects of nanomaterials. The purpose of this review is to present the current state of knowledge regarding the potential routes of human exposure to nanomaterials and their biological health effects. Although anthropogenic nanosized particles emitted in the environment are known to produce adverse human health in susceptible populations, much remains to be explored. Exposures can occur from direct exposure or from the use of commercial products made of nanomaterials. Safe manufacturing guidelines for prevention of exposures and recommendations on safe handling and use need to be established on a proactive basis to prevent adverse outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nanotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOTECHNOLOGY
KW - PUBLIC health
KW - PREVENTIVE medicine
KW - ENVIRONMENTAL health
KW - HEALTH risk assessment
KW - NANOPARTICLES
KW - Human health effects
KW - inhalation
KW - nanoparticles
KW - nanotechnology
KW - toxicity
N1 - Accession Number: 43202004; PAPP, THILO 1 SCHIFFMANN, DIETMAR 1 WEISS, DIETER 1 CASTRANOVA, VINCE 2 VALLYATHAN, VAL 2; Email Address: vav1@cdc.gov RAHMAN, QAMAR 3; Affiliation: 1: Institute of Cell Biology & Biosystems Technology, Rostock University Rostock, Germany. 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. 3: Dean Research & Development Integral University, Lucknow, India.; Source Info: Mar2008, Vol. 2 Issue 1, p9; Subject Term: NANOTECHNOLOGY; Subject Term: PUBLIC health; Subject Term: PREVENTIVE medicine; Subject Term: ENVIRONMENTAL health; Subject Term: HEALTH risk assessment; Subject Term: NANOPARTICLES; Author-Supplied Keyword: Human health effects; Author-Supplied Keyword: inhalation; Author-Supplied Keyword: nanoparticles; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 19p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1080/17435390701847935
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lok, Shee-Mei
AU - Kostyuchenko, Victor
AU - Nybakken, Grant E.
AU - Holdaway, Heather A.
AU - Battisti, Anthony J.
AU - Sukupolvi-Petty, Soila
AU - Sedlak, Dagmar
AU - Fremont, Daved H.
AU - Chipman, Paul R.
AU - Roehrig, John T.
AU - Diamond, Michael S.
AU - Kuhn, Richard J.
AU - Rossmann, Michael G.
T1 - Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2008/03//
VL - 15
IS - 3
M3 - Article
SP - 312
EP - 317
PB - Nature Publishing Group
SN - 15459993
AB - The monoclonal antibody 1A1D-2 has been shown to strongly neutralize dengue virus serotypes 1, 2 and 3, primarily by inhibiting attachment to host cells. A crystal structure of its antigen binding fragment (Fab) complexed with domain III of the viral envelope glycoprotein, E, showed that the epitope would be partially occluded in the known structure of the mature dengue virus. Nevertheless, antibody could bind to the virus at 37 °C, suggesting that the virus is in dynamic motion making hidden epitopes briefly available. A cryo-electron microscope image reconstruction of the virus:Fab complex showed large changes in the organization of the E protein that exposed the epitopes on two of the three E molecules in each of the 60 icosahedral asymmetric units of the virus. The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOCLONAL antibodies
KW - DENGUE viruses
KW - GLYCOPROTEINS
KW - ELECTRON microscopes
KW - ANTIGENIC determinants
KW - MOLECULAR biology
N1 - Accession Number: 31160951; Lok, Shee-Mei 1 Kostyuchenko, Victor 1 Nybakken, Grant E. 2 Holdaway, Heather A. 1 Battisti, Anthony J. 1 Sukupolvi-Petty, Soila 3 Sedlak, Dagmar 1,4 Fremont, Daved H. 2 Chipman, Paul R. 1 Roehrig, John T. 5 Diamond, Michael S. 2,3,6 Kuhn, Richard J. 1 Rossmann, Michael G. 1; Email Address: mr@purdue.edu; Affiliation: 1: Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907-2054, USA 2: Department of Pathology & Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA 3: Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA 4: Solid State Chemistry, An Aptuit Company, 3065 Kent Avenue, West Lafayette, Indiana 47906, USA 5: Arbovirus Disease Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522, USA 6: Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA; Source Info: Mar2008, Vol. 15 Issue 3, p312; Subject Term: MONOCLONAL antibodies; Subject Term: DENGUE viruses; Subject Term: GLYCOPROTEINS; Subject Term: ELECTRON microscopes; Subject Term: ANTIGENIC determinants; Subject Term: MOLECULAR biology; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 3 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1038/nsmb.1382
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duffy, Peter H.
AU - Lewis, Sherry M.
AU - Mayhugh, Martha A.
AU - Trotter, Ronald W.
AU - Hass, Bruce S.
AU - Thorn, Brett T.
AU - Feuers, Ritchie J.
T1 - Nonneoplastic pathology in male Sprague-Dawley rats fed the American Institute of Nutrition–93M purified diet at ad libitum and dietary-restricted intakes
JO - Nutrition Research
JF - Nutrition Research
Y1 - 2008/03//
VL - 28
IS - 3
M3 - Article
SP - 179
EP - 189
SN - 02715317
AB - Abstract: This study evaluates the effects of age and chronic dietary restriction (DR) on nonneoplastic diseases in rats that were fed the American Institute of Nutrition (AIN)–93M purified diet. Male Sprague-Dawley (SD) rats were divided into an ad libitum (AL) group and a DR group that was fed the AIN-93M diet with intake reduced by 31%. Nonneoplastic disease profiles were developed to clarify whether the AIN-93M diet fulfills long-term nutritional requirements of rats. Subsets of rats were killed at 58 and 114 weeks of age, and histopathology was performed. At 58 weeks of age, the 2 main types of nonneoplastic diseases in AL rats were liver vacuolization and cardiomyopathy. Dietary restriction reduced the severity and incidence of both lesions. At 114 weeks of age, the most common lesions in AL rats were cardiomyopathy, nephropathy, liver vacuolization, and degeneration with renal failure and genitourinary infections causing the greatest mortality. Dietary restriction reduced the incidence and severity of these lesions. Nonneoplastic diseases accounted for 28.9% and 0.0% of total mortalities in the AL and DR groups, respectively; however, there was a higher incidence of unknown deaths in the DR rats (52.6%) compared to AL rats (28.9%), which may have limited the success of DR to improve survival. Although the AIN-93M diet supported chronic rat growth, alterations in some dietary component concentrations may be required to lower body weight in chronic rodent and human studies. Factors such as diet composition and digestibility may alter nonneoplastic diseases and mortality in rats and humans in a similar fashion. [Copyright &y& Elsevier]
AB - Copyright of Nutrition Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIET in disease
KW - NUTRITION disorders
KW - RATS as laboratory animals
KW - CARDIOMYOPATHIES
KW - KIDNEY diseases
KW - ad libitum ( AL )
KW - American Institute of Nutrition ( AIN )
KW - Diet restriction ( DR )
KW - Dietary
KW - National Institutes of Health ( NIH )
KW - Nonneoplastic
KW - Pathology
KW - Rat
KW - Restriction
KW - Sprague-Dawley ( SD )
N1 - Accession Number: 31561593; Duffy, Peter H. 1; Email Address: peter.duffy@fda.hhs.gov Lewis, Sherry M. 2 Mayhugh, Martha A. 3 Trotter, Ronald W. 4 Hass, Bruce S. 1 Thorn, Brett T. 5 Feuers, Ritchie J. 6; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Office of Scientific Coordination, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 3: The Bionetics Corporation, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 4: Pathology Associates International, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 5: Z-Tech Incorporated, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 6: Division of Chemistry, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Mar2008, Vol. 28 Issue 3, p179; Subject Term: DIET in disease; Subject Term: NUTRITION disorders; Subject Term: RATS as laboratory animals; Subject Term: CARDIOMYOPATHIES; Subject Term: KIDNEY diseases; Author-Supplied Keyword: ad libitum ( AL ); Author-Supplied Keyword: American Institute of Nutrition ( AIN ); Author-Supplied Keyword: Diet restriction ( DR ); Author-Supplied Keyword: Dietary; Author-Supplied Keyword: National Institutes of Health ( NIH ); Author-Supplied Keyword: Nonneoplastic; Author-Supplied Keyword: Pathology; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Restriction; Author-Supplied Keyword: Sprague-Dawley ( SD ); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.nutres.2008.01.002
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DP - EBSCOhost
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ER -
TY - JOUR
AU - Rodriguez, William
AU - Selen, Arzu
AU - Avant, Debbie
AU - Chaurasia, Chandra
AU - Crescenzi, Terrie
AU - Gieser, Gerlie
AU - Di Giacinto, Jennifer
AU - Huang, Shiew-Mei
AU - Lee, Peter
AU - Mathis, Lisa
AU - Murphy, Dianne
AU - Murphy, Shirley
AU - Roberts, Rosemary
AU - Sachs, Hari Cheryl
AU - Suarez, Sandra
AU - Tandon, Veneeta
AU - Uppoor, Ramana S.
T1 - Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/03//
VL - 121
IS - 3
M3 - Article
SP - 530
EP - 539
SN - 00314005
AB - OBJECTIVE. The goal was to review the impact of pediatric drug studies, as measured by the improvement in pediatric dosing and other pertinent information captured in the drug labeling. METHODS. We reviewed the pediatric studies for 108 products submitted (July 1998 through October 2005) in response to a Food and Drug Administration written request for pediatric studies, and the subsequent labeling changes. We analyzed the dosing modifications and focused on drug clearance as an important parameter influencing pediatric dosing. RESULTS. The first 108 drugs with new or revised pediatric labeling changes had dosing changes or pharmacokinetic information (n = 23), new safety information (n = 34), information concerning lack of efficacy (n = 19), new pediatric formulations (n = 12), and extended age limits (n = 77). A product might have had ≥1 labeling change. We selected specific examples (n = 16) that illustrate significant differences in pediatric pharmacokinetics. CONCLUSIONS. Critical changes in drug labeling for pediatric patients illustrate that unique pediatric dosing often is necessary, reflecting growth and maturational stages of pediatric patients. These changes provide evidence that pediatric dosing should not be determined by simply applying weight-based calculations to the adult dose. Drug clearance is highly variable in the pediatric population and is not readily predictable on the basis of adult information. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSAGE of drugs
KW - PEDIATRICS
KW - PHARMACOKINETICS
KW - PATIENTS
KW - UNITED States
KW - bioavailability
KW - efficacy
KW - exposure
KW - labeling
KW - pediatric dosing
KW - pharmacodynamics
KW - pharmacokinetics
KW - pharmacology
KW - safety
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31283281; Rodriguez, William 1; Email Address: william.rodriguez@fda.hhs.gov Selen, Arzu 1 Avant, Debbie 1 Chaurasia, Chandra 1 Crescenzi, Terrie 1 Gieser, Gerlie 1 Di Giacinto, Jennifer 1 Huang, Shiew-Mei 1 Lee, Peter 1 Mathis, Lisa 1 Murphy, Dianne 1 Murphy, Shirley 1 Roberts, Rosemary 1 Sachs, Hari Cheryl 1 Suarez, Sandra 1 Tandon, Veneeta 1 Uppoor, Ramana S. 1; Affiliation: 1: Food and Drug Administration, Rockville, Maryland; Source Info: Mar2008, Vol. 121 Issue 3, p530; Subject Term: DOSAGE of drugs; Subject Term: PEDIATRICS; Subject Term: PHARMACOKINETICS; Subject Term: PATIENTS; Subject Term: UNITED States; Author-Supplied Keyword: bioavailability; Author-Supplied Keyword: efficacy; Author-Supplied Keyword: exposure; Author-Supplied Keyword: labeling; Author-Supplied Keyword: pediatric dosing; Author-Supplied Keyword: pharmacodynamics; Author-Supplied Keyword: pharmacokinetics; Author-Supplied Keyword: pharmacology; Author-Supplied Keyword: safety; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 10p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1542/peds.2007-1529
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105768009
T1 - Improving pediatric dosing through pediatric initiatives: what we have learned.
AU - Rodriguez W
AU - Selen A
AU - Avant D
AU - Chaurasia C
AU - Crescenzi T
AU - Gieser G
AU - Di Giacinto J
AU - Huang S
AU - Lee P
AU - Mathis L
AU - Murphy D
AU - Murphy S
AU - Roberts R
AU - Sachs HC
AU - Suarez S
AU - Tandon V
AU - Uppoor RS
Y1 - 2008/03//
N1 - Accession Number: 105768009. Language: English. Entry Date: 20080718. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Drug Evaluation -- Methods
KW - Drug Labeling -- Legislation and Jurisprudence
KW - Drug Labeling -- Standards
KW - Patient Safety
KW - Pediatrics -- Standards
KW - Administration, Oral
KW - Adolescence
KW - Age Factors
KW - Biological Availability
KW - Body Surface Area
KW - Child
KW - Child, Preschool
KW - Dose-Response Relationship, Drug
KW - Drug Administration Schedule
KW - Female
KW - Infant
KW - Male
KW - Sensitivity and Specificity
KW - United States
KW - United States Food and Drug Administration
KW - Human
SP - 530
EP - 539
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 121
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: The goal was to review the impact of pediatric drug studies, as measured by the improvement in pediatric dosing and other pertinent information captured in the drug labeling. METHODS: We reviewed the pediatric studies for 108 products submitted (July 1998 through October 2005) in response to a Food and Drug Administration written request for pediatric studies, and the subsequent labeling changes. We analyzed the dosing modifications and focused on drug clearance as an important parameter influencing pediatric dosing. RESULTS: The first 108 drugs with new or revised pediatric labeling changes had dosing changes or pharmacokinetic information (n = 23), new safety information (n = 34), information concerning lack of efficacy (n = 19), new pediatric formulations (n = 12), and extended age limits (n = 77). A product might have had > or = 1 labeling change. We selected specific examples (n = 16) that illustrate significant differences in pediatric pharmacokinetics. CONCLUSIONS: Critical changes in drug labeling for pediatric patients illustrate that unique pediatric dosing often is necessary, reflecting growth and maturational stages of pediatric patients. These changes provide evidence that pediatric dosing should not be determined by simply applying weight-based calculations to the adult dose. Drug clearance is highly variable in the pediatric population and is not readily predictable on the basis of adult information.
SN - 0031-4005
AD - Food and Drug Administration, 5600 Fisher Lane, Parklawn Building, Room 13B-45, Rockville, MD 20850, USA. william.rodriguez@fda.hhs.gov
U2 - PMID: 18310202.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105768021
T1 - Toward better vaccine safety data and safer vaccination.
AU - Braun MM
Y1 - 2008/03//
N1 - Accession Number: 105768021. Language: English. Entry Date: 20080718. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Immunization -- Adverse Effects
KW - Measles-Mumps-Rubella Vaccine -- Administration and Dosage
KW - Measles-Mumps-Rubella Vaccine -- Adverse Effects
KW - Purpura, Thrombocytopenic -- Etiology
KW - Purpura, Thrombocytopenic -- Risk Factors
KW - Adverse Drug Event
KW - Centers for Disease Control and Prevention (U.S.)
KW - Child, Preschool
KW - Drug Toxicity
KW - Female
KW - Immunization Schedule
KW - Immunization -- Methods
KW - Infant
KW - Male
KW - Purpura, Thrombocytopenic -- Epidemiology
KW - Risk Assessment
KW - United States
SP - 625
EP - 626
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 121
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-220, 1401 Rockville Pike, Rockville, MD 20852, USA. miles.braun@fda.hhs.gov
U2 - PMID: 18310214.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Leslie Benet
AU - Gordon Amidon
AU - Dirk Barends
AU - Hans Lennernäs
AU - James Polli
AU - Vinod Shah
AU - Salomon Stavchansky
AU - Lawrence Yu
T1 - The Use of BDDCS in Classifying the Permeability of Marketed Drugs.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2008/03//
VL - 25
IS - 3
M3 - Article
SP - 483
EP - 488
SN - 07248741
AB - Abstract  We recommend that regulatory agencies add the extent of drug metabolism (i.e.,ââ¥â90% metabolized) as an alternate method in defining Class 1 marketed drugs suitable for a waiver of in vivo studies of bioequivalence. That is,ââ¥â90% metabolized is an additional methodology that may be substituted forââ¥â90% absorbed. We propose that the following criteria be used to defineââ¥â90% metabolized for marketed drugs: Following a single oral dose to humans, administered at the highest dose strength, mass balance of the Phase 1 oxidative and Phase 2 conjugative drug metabolites in the urine and feces, measured either as unlabeled, radioactive labeled or nonradioactive labeled substances, account forââ¥â90% of the drug dosed. This is the strictest definition for a waiver based on metabolism. For an orally administered drug to beââ¥â90% metabolized by Phase 1 oxidative and Phase 2 conjugative processes, it is obvious that the drug must be absorbed. This proposal, which strictly conforms to the presentââ¥â90% criteria, is a suggested modification to facilitate a number of marketed drugs being appropriately assigned to Class 1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PERMEABILITY
KW - ADSORPTION
KW - DRUGS
KW - BIOACTIVE compounds
N1 - Accession Number: 31843607; Leslie Benet 1 Gordon Amidon 2 Dirk Barends 3 Hans Lennernäs 4 James Polli 5 Vinod Shah 6 Salomon Stavchansky 7 Lawrence Yu 8; Affiliation: 1: University of California San Francisco Department of Biopharmaceutical Sciences 533 Parnassus Avenue, Room U-68 San Francisco California 94143-0446 USA 2: University of Michigan, College of Pharmacy Department of Pharmaceutics Ann Arbor Michigan 48109-1065 USA 3: RIVM-National Institute for Public Health and the Environment Bilthoven The Netherlands 4: University of Uppsala Department of Pharmacy, Division of Biopharmaceutics and Pharmacokinetics S-75123 Uppsala Sweden 5: University of Maryland, School of Pharmacy Department of Pharmaceutical Sciences Baltimore Maryland 21201 USA 6: North Potomac Maryland 20878 USA 7: University of Texas at Austin Pharmaceutics Division, College of Pharmacy Austin Texas 78712 USA 8: Office of Pharmaceutical Science Food and Drug Administration, Center for Drug Evaluation and Research 10903 New Hampshire Avenue Silver Spring Maryland 20993 USA; Source Info: Mar2008, Vol. 25 Issue 3, p483; Subject Term: PERMEABILITY; Subject Term: ADSORPTION; Subject Term: DRUGS; Subject Term: BIOACTIVE compounds; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McAdams, Mara
AU - Staffa, Judy
AU - Dal Pan, Gerald
T1 - Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/03//
VL - 17
IS - 3
M3 - Article
SP - 229
EP - 239
SN - 10538569
AB - Purpose To estimate the extent of reporting to FDA through statin-associated rhabdomyolysis data. Methods Data included incidence rates (IRs) of hospitalized rhabdomyolysis among statin users from a population-based study, and comparable reported AERS cases and national estimates of statin use from an AERS analysis. Using IRs, national estimates of statin use and average days supply per prescription, we estimated the number of US statin-associated cases of hospitalized rhabdomyolysis. We compared this estimate to the observed number of cases reported to FDA to evaluate the extent of reporting. We repeated this method for atorvastatin, cerivastatin, pravastatin, and simvastatin and statin combinations. We performed sensitivity analyses to check for biases such as misclassification of statin use and cohort selection bias. We evaluated potential time-dependent cerivastatin reporting by a 'Dear Health Care Provider (DHCP)' letter. Results The estimated extent of reporting to FDA varied by statin (atorvastatin, 5.0%; cerivastatin, 31.2%; simvastatin, 14.2%; all four combined, 17.7%; and non-cerivastatin statins combined, 9.9%). No pravastatin-associated cohort cases occurred. Across a reasonable value range, sensitivity analyses did not significantly alter the results; overall the cohort was similar to national statin-users. There was a large increase in AERS reports after the cerivastatin DHCP letter and the estimated extent of reporting increased from 14.8 to 35.0%. Conclusions The extent of reporting of adverse events to FDA varied by statin and may be influenced by publicity. For statins-associated rhabdomyolysis, the estimated extent of reporting appears to range from 5 to 30% but in the absence of stimulated reporting appears to be 5-15%. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707717; McAdams, Mara 1; Staffa, Judy 1; Dal Pan, Gerald 1; Affiliations: 1: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Mar2008, Vol. 17 Issue 3, p229; Number of Pages: 11p; Document Type: Article
L3 - 10.1002/pds.1535
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Andrade, Susan E.
AU - Raebel, Marsha A.
AU - Brown, Jeffrey
AU - Lane, Kimberly
AU - Livingston, James
AU - Boudreau, Denise
AU - Rolnick, Sharon J.
AU - Roblin, Douglas
AU - Smith, David H.
AU - Dal Pan, Gerald J.
AU - Scott, Pamela E.
AU - Platt, Richard
T1 - Outpatient use of cardiovascular drugs during pregnancy.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/03//
VL - 17
IS - 3
M3 - Article
SP - 240
EP - 247
SN - 10538569
AB - Purpose To provide information on the prevalence of use of cardiovascular drugs, some of which may have fetotoxic or teratogenic effects, in the outpatient setting among pregnant women in the United States. Methods A retrospective study was conducted using the automated databases of seven health plans participating in the HMO Research Network Center for Education and Research on Therapeutics (CERT). Women who delivered an infant from 1 January 2001 to 31 December 2005 were identified. Cardiovascular drug use was evaluated assuming a gestational duration of 270 days. Results During the period 2001 through 2005, 118 935 deliveries were identified that met the criteria for study; 3.1% of women ( N = 3672) were dispensed an antihypertensive medication and 0.12% of women ( N = 146) were dispensed an antihyperlipidemic medication at any time during pregnancy. The most common antihypertensive drugs dispensed during pregnancy were nifedipine (1219 deliveries; 1.0%), methyldopa (961 deliveries; 0.8%), atenolol (593 deliveries; 0.5%), and labetalol (576 deliveries; 0.5%). Overall, 134 women (0.11%) received an angiotensin converting enzyme (ACE) inhibitor and 7 women (0.006%) received an angiotensin II receptor blocker (ARB) during pregnancy. Statins were the most commonly dispensed antihyperlipidemic drugs (71 deliveries; 0.06%). Conclusions The prevalence of use of cardiovascular drugs that are suspected to be fetotoxic or teratogenic (ACE inhibitors, ARBs, and statins) was low in this cohort of pregnant women. Differing patterns of use across health plans suggests that further research is needed to evaluate the potential differential effects of cardiovascular drugs to assist prescribers and patients in making informed treatment decisions. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707721; Andrade, Susan E. 1,2; Raebel, Marsha A. 2,3; Brown, Jeffrey 2,4; Lane, Kimberly 2,4; Livingston, James 2,4; Boudreau, Denise 2,5; Rolnick, Sharon J. 2,6; Roblin, Douglas 2,7; Smith, David H. 2,8; Dal Pan, Gerald J. 9; Scott, Pamela E. 10; Platt, Richard 2,4; Affiliations: 1: Meyers Primary Care Institute (University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan), Worcester, MA, USA; 2: The HMO Research Network Center for Education and Research in Therapeutics, USA; 3: Kaiser Permanente Colorado, Denver, CO, USA; 4: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA; 5: Center for Health Studies, Group Health Cooperative, Seattle, WA, USA; 6: HealthPartners Research Foundation, Minneapolis, MN, USA; 7: Kaiser Permanente Georgia, Atlanta, GA, USA; 8: Kaiser Permanente Northwest, Portland, OR, USA; 9: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; 10: Office of Women's Health, Food and Drug Administration, Rockville, MD, USA; Issue Info: Mar2008, Vol. 17 Issue 3, p240; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1550
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DP - EBSCOhost
DB - eih
ER -
TY - CASE
AU - Morgan, Oliver W.
AU - Rodrigues, Boaventura
AU - Elston, Tony
AU - Verlander, Neville Q.
AU - Brown, Derek F. J.
AU - Brazier, Jonathan
AU - Reacher, Mark
T1 - Clinical Severity of Clostridium difficile PCR Ribotype 027: A Case-Case Study.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2008/03//
VL - 3
IS - 3
M3 - Case Study
SP - 1
EP - 6
PB - Public Library of Science
SN - 19326203
AB - Background: Clostridium difficile is a leading infectious cause of health care associated diarrhoea. Several industrialised countries have reported increased C. difficile infections and outbreaks, which have been attributed to the emergent PCR ribotype 027 strain. Methods and Findings: We conducted a case-case study to compare severity of C. difficile disease for patients with 027 versus non-027 ribotypes. We retrospectively collected clinical information about 123/136 patients with C. difficile infections admitted to hospitals in the East of England region in 2006 and from whom stool isolates were cultured and ribotyped as part of an earlier national survey. We defined severe C. difficile disease as having one or more of shock, paralytic ileus, pseudo membranous colitis or toxic megacolon. Patient median age was 83 years old (range 3 to 98, interquartile range 75 to 89), 86% were prescribed antibiotics in the eight weeks before illness onset, 41% had ribotype 027 and 30-day all cause mortality during hospital admission was 21%. Severe disease occurred in 24% (95%CI 13% to 37%) and 17% (95%CI 9% to 27%) of patients with PCR ribotype 027 and non-027 ribotypes respectively. In a multivariable model, ribotype 027 was not associated with severe disease after adjusting for sex, discharge from hospital prior to 60 days of current admission, gastroenteritis on admission, number of initiator antibiotics for C. difficile disease, and hospital where the patient was admitted. Conclusions: Our study found no evidence to support previous assertions that ribotype 027 is more virulent than other PCR ribotypes. This finding raises questions about the contribution of this strain to the recent increase in C. difficile disease throughout North America and Europe. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM difficile
KW - DIARRHEA
KW - GASTROENTERITIS
KW - ANTI-infective agents
KW - CASE studies
KW - NORTH America
KW - EUROPE
N1 - Accession Number: 55507299; Morgan, Oliver W. 1; Email Address: omorgan@bigfoot.com Rodrigues, Boaventura 2 Elston, Tony 3 Verlander, Neville Q. 4 Brown, Derek F. J. 5 Brazier, Jonathan 6 Reacher, Mark 1; Affiliation: 1: East of England Regional Epidemiology Unit, Health Protection Agency, Cambridge, United Kingdom 2: Eastern Deanery Public Health Training Scheme, Cambridge, United Kingdom 3: Essex Rivers NHS Trust, Colchester, United Kingdom 4: Statistics, Modelling and Bioinformatics Department, Centre for Infections, Health Protection Agency, London, United Kingdom 5: Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrookes Hospital, Cambridge, United Kingdom 6: Anaerobe Reference Laboratory, National Public Health Service, University Hospital of Wales, Cardiff, United Kingdom; Source Info: 2008, Vol. 3 Issue 3, p1; Subject Term: CLOSTRIDIUM difficile; Subject Term: DIARRHEA; Subject Term: GASTROENTERITIS; Subject Term: ANTI-infective agents; Subject Term: CASE studies; Subject Term: NORTH America; Subject Term: EUROPE; Number of Pages: 6p; Illustrations: 5 Charts, 1 Graph; Document Type: Case Study
L3 - 10.1371/journal.pone.0001812
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=55507299&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reed, Laurence D.
T1 - A Message from the Editor.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/03//Mar/Apr2008
VL - 123
IS - 2
M3 - Article
SP - 109
EP - 109
SN - 00333549
AB - The article discusses various reports published within the issue including articles on leprosy or Hansen's disease, coordinated by Drs. Brian Bennett, David Parker and Mark Robson.
KW - LEPROSY
KW - MYCOBACTERIAL diseases
N1 - Accession Number: 31126255; Reed, Laurence D. 1; Affiliation: 1: Captain, U.S. Public Health Service; Source Info: Mar/Apr2008, Vol. 123 Issue 2, p109; Subject Term: LEPROSY; Subject Term: MYCOBACTERIAL diseases; Number of Pages: 1p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31126255&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hoflund, A. Bryce
AU - Farquhar, Marybeth
T1 - Challenges of democratic experimentalism: A case study of the National Quality Forum in health care.
JO - Regulation & Governance
JF - Regulation & Governance
Y1 - 2008/03//
VL - 2
IS - 1
M3 - Article
SP - 121
EP - 135
SN - 17485983
AB - Networks are an increasingly common aspect of administrative life in almost any public policy arena. In health care, networks have emerged in order to address “wicked” quality problems. One such network organization, the National Quality Forum (NQF), was created as a response to the fragmentation and information deficit that have plagued the health care industry’s efforts to improve health care quality. Its purpose is to bring diverse health care stakeholders from the public and private sectors together to discuss and debate quality and performance measurement issues. Democratic experimentalism offers one way of assessing the NQF’s efforts. The purpose of this article is to examine the NQF’s efforts through the lens of democratic experimentalism and to explore some of the virtues and shortcomings of applying a democratic experimentalist approach to health care regulation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Regulation & Governance is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - HEALTH care industry
KW - PUBLIC administration
KW - TRADE regulation
KW - POLITICAL planning
KW - democratic experimentalism
KW - health care
KW - network
KW - new governance
KW - regulation
N1 - Accession Number: 34223662; Hoflund, A. Bryce 1; Email Address: ahoflund@vt.edu; Farquhar, Marybeth 2; Affiliations: 1: Center for Public Administration and Policy, Virginia Tech, Blacksburg, VA, USA; 2: Center for Delivery, Organizations and Markets, Agency for Healthcare Research and Quality, Rockville, MD, USA; Issue Info: Mar2008, Vol. 2 Issue 1, p121; Thesaurus Term: MEDICAL care; Thesaurus Term: HEALTH care industry; Thesaurus Term: PUBLIC administration; Thesaurus Term: TRADE regulation; Subject Term: POLITICAL planning; Author-Supplied Keyword: democratic experimentalism; Author-Supplied Keyword: health care; Author-Supplied Keyword: network; Author-Supplied Keyword: new governance; Author-Supplied Keyword: regulation; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; Number of Pages: 15p; Document Type: Article
L3 - 10.1111/j.1748-5991.2007.00031.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=34223662&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Trubek, Louise G.
AU - Rees, Joseph V.
AU - Hoflund, A. Bryce
AU - Farquhar, Marybeth
AU - Heimer, Carol A.
AD - Unlisted
AD - VA Polytechnic Institute & State U
AD - Center for Public Administration and Policy, VA Polytechnic Institute & State U
AD - Center for Delivery, Organizations and Markets, Agency for Healthcare Research and Quality, Rockville, MD
AD - Northwestern U
T1 - Health Care and New Governance: The Quest for Effective Regulation
JO - Regulation and Governance
JF - Regulation and Governance
Y1 - 2008/03//
VL - 2
IS - 1
SP - 1
EP - 8
SN - 17485983
N1 - Accession Number: 1092970; Keywords: Health; Health Care; Regulation; Geographic Descriptors: EU; U.S.; Geographic Region: Europe; Northern America; Publication Type: Journal Article; Update Code: 201003
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
KW - Economics of Regulation L51
L3 - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291748-5991/issues
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1092970&site=ehost-live&scope=site
UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291748-5991/issues
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Simmons, Greg
AU - Jury, Sheryl
AU - Thornley, Craig
AU - Harte, David
AU - Mohiuddin, Jasmine
AU - Taylor, Michael
T1 - A Legionnaires’ disease outbreak: A water blaster and roof-collected rainwater systems
JO - Water Research
JF - Water Research
Y1 - 2008/03//
VL - 42
IS - 6/7
M3 - Article
SP - 1449
EP - 1458
SN - 00431354
AB - Abstract: In February 2006, an outbreak of Legionnaires’ disease (LD) was identified in Beachlands, a small, isolated east Auckland suburb. It was investigated through case finding, a case–control study, sampling potential sources of infection and by molecular typing (using sequence-based typing (SBT) of all Legionella pneumophila serogroup 1 (Lp1) isolates). Lp1 was isolated from the respiratory tract of one case, the roof-collected rainwater systems of five households (three associated with cases) and from a water blaster at a nearby marina. All isolates were indistinguishable, exhibiting the same SBT allele pattern. Three LD cases lived within 500m of the water blaster (the fourth case within 1250m) and downwind in prevailing conditions. Another domestic roof-collected rainwater supply contaminated by Lp1 (identical SBT pattern) was incidentally identified in another suburb 4km east of Beachlands. This is the first outbreak of LD linked to roof-collected rainwater supplies and the first isolation of Legionella from these systems in New Zealand. Aerosols containing Legionella discharged to air by the marina water blaster may have infected some cases directly or may have seeded roof-collected rainwater systems. Some cases may have been exposed by contaminated bathroom showers. Roof-collected rainwater systems need appropriate design, careful cleaning and the maintenance of hot water temperatures at a minimum of 60°C to reduce the chances of Legionella multiplying. Further research into the ecology of Legionella in roof-collected rain water systems is indicated. [Copyright &y& Elsevier]
AB - Copyright of Water Research is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gram-negative bacterial diseases
KW - Water pollution
KW - Water quality
KW - Water harvesting
KW - Runoff
KW - Water conservation
KW - Rainwater
KW - Legionnaires' disease
KW - Respiratory infections
KW - Respiratory diseases
KW - Legionella pneumophila
KW - Auckland (N.Z.)
KW - New Zealand
KW - Aerosols
KW - Legionella pneumophila serogroup 1
KW - Legionnaires’ disease
KW - Sequence-based typing
KW - Water blaster
KW - Water tanks
N1 - Accession Number: 31303148; Simmons, Greg 1; Email Address: gregs@adhb.govt.nz; Jury, Sheryl 1; Email Address: SJury@adhb.govt.nz; Thornley, Craig 1; Email Address: CraigT@adhb.govt.nz; Harte, David 2; Email Address: David.harte@esr.cri.nz; Mohiuddin, Jasmine 1; Email Address: JasmineM@adhb.govt.nz; Taylor, Michael 3; Email Address: michael_taylor@moh.govt.nz; Affiliations: 1: Auckland Regional Public Health Service, Private Bag 92 605, Symonds Street, Auckland 1035, New Zealand; 2: Institute of Environmental Science and Research, PO Box 50 348, Porirua, Wellington, New Zealand; 3: New Zealand Ministry of Health, PO Box 5013, Wellington, New Zealand; Issue Info: Mar2008, Vol. 42 Issue 6/7, p1449; Thesaurus Term: Gram-negative bacterial diseases; Thesaurus Term: Water pollution; Thesaurus Term: Water quality; Thesaurus Term: Water harvesting; Thesaurus Term: Runoff; Thesaurus Term: Water conservation; Thesaurus Term: Rainwater; Subject Term: Legionnaires' disease; Subject Term: Respiratory infections; Subject Term: Respiratory diseases; Subject Term: Legionella pneumophila; Subject: Auckland (N.Z.); Subject: New Zealand; Author-Supplied Keyword: Aerosols; Author-Supplied Keyword: Legionella pneumophila serogroup 1; Author-Supplied Keyword: Legionnaires’ disease; Author-Supplied Keyword: Sequence-based typing; Author-Supplied Keyword: Water blaster; Author-Supplied Keyword: Water tanks; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.watres.2007.10.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31303148&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Wilson, Carolyn
AU - Fishman, Jay A.
AU - Sykes, Megan
T1 - Tribute to Eda T. Bloom, PhD.
JO - Xenotransplantation
JF - Xenotransplantation
Y1 - 2008/03//Mar/Apr2008
VL - 15
IS - 2
M3 - Obituary
SP - 69
EP - 71
PB - Wiley-Blackwell
SN - 0908665X
AB - An obituary for Eda T. Bloom, an immunologist is presented.
KW - BLOOM, Eda T.
N1 - Accession Number: 31791035; Wilson, Carolyn 1 Fishman, Jay A. 2 Sykes, Megan 3; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 2: Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital/Harvard Medical School Infectious Disease Division 3: Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Source Info: Mar/Apr2008, Vol. 15 Issue 2, p69; People: BLOOM, Eda T.; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Obituary
L3 - 10.1111/j.1399-3089.2008.00448.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31791035&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-04573-001
AN - 2008-04573-001
AU - Smith, Douglas C.
AU - Muck, Randolph D.
T1 - Editors' introduction: SAMHSA's Strengthening Communities for Youth (SCY) initiative.
JF - Journal of Psychoactive Drugs
JO - Journal of Psychoactive Drugs
JA - J Psychoactive Drugs
Y1 - 2008/03//
VL - 40
IS - 1
SP - 1
EP - 2
CY - US
PB - Haight-Ashbury Publications
SN - 0279-1072
SN - 2159-9777
AD - Smith, Douglas C., University of Iowa, Department of Pediatrics, 100 Oakdale Hall M304, Iowa City, IA, US
N1 - Accession Number: 2008-04573-001. PMID: 18472660 Other Journal Title: Journal of Psychedelic Drugs. Partial author list: First Author & Affiliation: Smith, Douglas C.; Department of Pediatrics, University of Iowa, Iowa City, IA, US. Other Publishers: Taylor & Francis. Release Date: 20080428. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Health Care Utilization; Life Changes; Outpatient Treatment; Quality of Care. Classification: Outpatient Services (3371). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2008.
AB - The first three articles address adolescents' transitions through the system of care. The first article gives an overview of the Strengthening Communities for Youth (SCY) project's goals and present data from sites that agreed to use common measures to evaluate outcomes. The second authors used their site's data to show local patterns of service utilization, and found that transitions between levels of care were common, with over 40% of youth who started in outpatient treatment receiving additional services. The next two articles address engaging adolescents into substance abuse treatment within the system of care. In summary, this issue contains a nonexhaustive sampling of lessons learned by the SCY communities about enhancing client outcomes through focusing on systems level changes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescents transitions
KW - system of care
KW - service utilization
KW - outpatient treatment
KW - 2008
KW - Health Care Utilization
KW - Life Changes
KW - Outpatient Treatment
KW - Quality of Care
KW - 2008
U1 - Sponsor: Center for Substance Abuse Treatment. Grant: TI-13323, TI-13313; TM3356; TI-13354; TI-13345; TI-13305; TI-13322; TI-13344. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 270-2003-00006. Recipients: No recipient indicated
DO - 10.1080/02791072.2008.10399756
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04573-001&site=ehost-live&scope=site
UR - douglas-c-smith@uiowa.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04573-002
AN - 2008-04573-002
AU - Dennis, Michael L.
AU - Ives, Melissa L.
AU - White, Michelle K.
AU - Muck, Randolph D.
T1 - The Strengthening Communities for Youth (SCY) initiative: A cluster analysis of the services received, their correlates and how they are associated with outcomes.
JF - Journal of Psychoactive Drugs
JO - Journal of Psychoactive Drugs
JA - J Psychoactive Drugs
Y1 - 2008/03//
VL - 40
IS - 1
SP - 3
EP - 16
CY - US
PB - Haight-Ashbury Publications
SN - 0279-1072
SN - 2159-9777
AD - Dennis, Michael L., Chestnut Health Systems, 720 West Chestnut, Bloomington, IL, US, 61701
N1 - Accession Number: 2008-04573-002. PMID: 18472661 Other Journal Title: Journal of Psychedelic Drugs. Partial author list: First Author & Affiliation: Dennis, Michael L.; Chestnut Health Systems, Bloomington, IL, US. Other Publishers: Taylor & Francis. Release Date: 20080428. Correction Date: 20121001. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Community Mental Health Services; Health Service Needs; Treatment Outcomes; Trends. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: GAIN Records Log; Working Alliance Inventory; Global Appraisal of Individual Needs. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Mar, 2008.
AB - This article describes the Strengthening Communities for Youth (SCY) initiative using data from 1,297 adolescents in eight U.S. cities (Oakland, CA; Tucson, AZ; Iowa City, IA; Bloomington, IL; St. Louis, MO; Cleveland, OH; Louisville, KY, New York, NY) to better understand the pattern of services they received, how these services varied by need, and how services were associated with initial treatment outcomes. Data include adolescent reports collected with the Global Assessment of Individual Needs (GAIN) at treatment intake and 90 days post-intake, information on early therapeutic alliance using a modified Working Alliance Inventory (WAI), and staff reports from service logs. Cluster analysis identified four patterns of treatment received: (1) substance abuse and mental health treatment, (2) primarily residential treatment, (3) interrupted treatment, and (4) primarily outpatient treatment. Outcomes examined included changes in substance use, substance abuse/dependence problems, recovery environment risk, as well as risk from social peers, illegal activity and emotional problems. Overall and for most groups, treatment was associated with reduced or unchanged problems in each of these areas. The exception was for cluster 1, for whom emotional problems actually increased. Implications for placement, treatment planning and future research are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Strengthening Communities for Youth initiative
KW - pattern of services
KW - adolescents
KW - treatment outcomes
KW - needs
KW - 2008
KW - Adolescent Development
KW - Community Mental Health Services
KW - Health Service Needs
KW - Treatment Outcomes
KW - Trends
KW - 2008
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. Grant: 270-2003-00006; TI-13323. Other Details: James Dahl, Phoenix Programs of New York, Inc.. Recipients: No recipient indicated
DO - 10.1080/02791072.2008.10399757
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04573-002&site=ehost-live&scope=site
UR - mdennis@chestnut.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-03373-001
AN - 2008-03373-001
AU - Brown, David G.
AU - Si, Jennie
AU - Sun, Ron
T1 - Special Issue on Advances in Neural Networks Research: IJCNN'07.
JF - Neural Networks
JO - Neural Networks
JA - Neural Netw
Y1 - 2008/03//Mar-Apr, 2008
VL - 21
IS - 2-3
SP - 113
EP - 113
CY - Netherlands
PB - Elsevier Science
SN - 0893-6080
AD - Brown, David G.
N1 - Accession Number: 2008-03373-001. PMID: 18262753 Partial author list: First Author & Affiliation: Brown, David G.; Center for Devices and Radiological Health, FDA, US. Release Date: 20080512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Conference Information: International Joint Conference on Neural Networks, Aug, 2007, Orlando, FL, US. Major Descriptor: Experimentation; Neural Networks. Classification: Neural Networks (4160). Page Count: 1. Issue Publication Date: Mar-Apr, 2008.
AB - This Special Issue also celebrates a significant anniversary, its third biennial edition. Beginning in 2003, the authors of the top-ranked conference proceedings papers during the International Neural Network Society (INNS) managed (odd) years have been invited to extend and rework their papers for publication in a Special Issue of Neural Networks. This Special Issue is the third in a series that we trust will be an ongoing feature of the International Joint Conference on Neural Networks (IJCNN) conferences. IJCNN'07 was held August 12-17, 2007 in Orlando, Florida. Of a total of 811 submissions, 267 were selected for oral presentation and 272 for poster presentation at the conference. Of the 539 presented papers, just 45 survived a rigorous winnowing process to merit their inclusion in this Special Issue. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neural networks
KW - conference proceedings
KW - advances
KW - 2008
KW - Experimentation
KW - Neural Networks
KW - 2008
DO - 10.1016/j.neunet.2008.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03373-001&site=ehost-live&scope=site
UR - rsun@rpi.edu
UR - si@asu.edu
UR - david.brown@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-02449-005
AN - 2008-02449-005
AU - Strine, Tara W.
AU - Mokdad, Ali H.
AU - Dube, Shanta R.
AU - Balluz, Lina S.
AU - Gonzalez, Olinda
AU - Berry, Joyce T.
AU - Manderscheid, Ron
AU - Kroenke, Kurt
T1 - The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults.
JF - General Hospital Psychiatry
JO - General Hospital Psychiatry
JA - Gen Hosp Psychiatry
Y1 - 2008/03//
VL - 30
IS - 2
SP - 127
EP - 137
CY - Netherlands
PB - Elsevier Science
SN - 0163-8343
AD - Strine, Tara W., Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-02449-005. PMID: 18291294 Partial author list: First Author & Affiliation: Strine, Tara W.; Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20080414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Anxiety; Health Behavior; Major Depression. Minor Descriptor: Alcohol Drinking Patterns; Obesity; Physical Activity; Tobacco Smoking. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: Puerto Rico; US; US Virgin Islands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: BRFSS Anxiety and Depression Module; Patient Health Questionnaire DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Data Sets Internet. References Available: Y. Page Count: 11. Issue Publication Date: Mar, 2008.
AB - Objective: The aim of this study was to examine the extent to which depression and anxiety are associated with smoking, obesity, physical inactivity and alcohol consumption in the US population using the Patient Health Questionnaire 8 (PHQ-8) and two questions on lifetime diagnosis of anxiety and depression. Methods: Data were analyzed in 38 states, the District of Columbia and two territories using the 2006 Behavioral Risk Factor Surveillance System (n=217,379), a large state-based telephone survey. Results: Overall, adults with current depression or a lifetime diagnosis of depression or anxiety were significantly more likely than those without each diagnosis to smoke, to be obese, to be physically inactive, to binge drink and drink heavily. There was a dose-response relationship between depression severity and the prevalence of smoking, obesity and physical inactivity and between history of depression (never depressed, previously depressed, currently depressed) and the prevalence of smoking, obesity, physical inactivity, binge drinking and heavy drinking. Lifetime diagnosis of depression and anxiety had an additive association with smoking prevalence. Conclusion: The associations between depression, anxiety, obesity and unhealthy behaviors among US adults suggest the need for a multidimensional and integrative approach to health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - anxiety
KW - smoking
KW - obesity
KW - physical inactivity
KW - alcohol consumption
KW - unhealthy behaviors
KW - 2008
KW - Anxiety
KW - Health Behavior
KW - Major Depression
KW - Alcohol Drinking Patterns
KW - Obesity
KW - Physical Activity
KW - Tobacco Smoking
KW - 2008
DO - 10.1016/j.genhosppsych.2007.12.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-02449-005&site=ehost-live&scope=site
UR - tws2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11418-009
AN - 2008-11418-009
AU - Andrew, Michael E.
AU - McCanlies, Erin C.
AU - Burchfiel, Cecil M.
AU - Charles, Luenda
AU - Hartley, Tara A.
AU - Fekedulegn, Desta
AU - Violanti, John M.
T1 - Hardiness and psychological distress in a cohort of police officers.
T3 - Resiliency and invulnerability in law enforcement
JF - International Journal of Emergency Mental Health
JO - International Journal of Emergency Mental Health
JA - Int J Emerg Ment Health
Y1 - 2008///Spr 2008
VL - 10
IS - 2
SP - 137
EP - 148
CY - US
PB - Chevron Publishing
SN - 1522-4821
AD - Andrew, Michael E., National Institute of Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Drive, Morgantown, WV, US, 26505
N1 - Accession Number: 2008-11418-009. Other Journal Title: International Journal of Emergency Mental Health and Human Resilience. Partial author list: First Author & Affiliation: Andrew, Michael E.; National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV, US. Other Publishers: OMICS Group. Release Date: 20080922. Correction Date: 20140728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Distress; Police Personnel; Posttraumatic Stress Disorder; Resilience (Psychological). Classification: Psychological & Physical Disorders (3200); Police & Legal Personnel (4290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Impact of Events scale; Brief Symptom Inventory DOI: 10.1037/t00789-000; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Spr 2008.
AB - Since police officers are frequently exposed to high stress situations, individual differences in the response to stress and trauma are of interest. We examined the association of hardiness components (commitment, control and challenge) with depression, posttraumatic stress disorder (PTSD) symptoms, and symptoms of general psychological distress in police officers. The random sample included 105 officers (40 women and 65 men) from the Buffalo Cardio-Metabolic Police Stress (BCOPS) study baseline visit. Components of hardiness were measured using a 15-item hardiness scale. Depressive symptoms were measured using the Center for Epidemiological Studies Depression scale (CES-D), PTSD symptoms were measured using the impact of events scale (IES), and symptoms of general psychological distress were measured using the Brief Symptoms Inventory (BSI). Associations were assessed using linear regression analysis. Models were adjusted for age, education and marital status. Because of significant gender interactions, analyses were stratified by gender. The hardiness control dimension was significantly and negatively associated with CES-D for both genders but was not associated with IES. Hardiness commitment was significantly and negatively associated with both CES-D and IES in women. Men had negative but non-significant associations for commitment with CES-D and IES. Hardiness commitment was negatively associated with the overall BSI score for both men and women but the association was only significant for men, though the strength of the association was stronger for women. This is likely a result of the impact of the smaller sample size for women. The magnitude of gender differences in these associations shows that for depressive and PTSD symptoms, the commitment dimension of hardiness may be more protective in female police officers than in male officers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - police officers
KW - hardiness
KW - PTSD
KW - distress
KW - depression
KW - 2008
KW - Distress
KW - Police Personnel
KW - Posttraumatic Stress Disorder
KW - Resilience (Psychological)
KW - 2008
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: IR03OH003772-01. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11418-009&site=ehost-live&scope=site
UR - mta6@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04851-006
AN - 2008-04851-006
AU - Matthieu, Monica M.
AU - Cross, Wendi
AU - Batres, Alfonso R.
AU - Flora, Charles M.
AU - Knox, Kerry L.
T1 - Evaluation of gatekeeper training for suicide prevention in veterans.
JF - Archives of Suicide Research
JO - Archives of Suicide Research
JA - Arch Suicide Res
Y1 - 2008/03//
VL - 12
IS - 2
SP - 148
EP - 154
CY - Germany
PB - Springer
SN - 1381-1118
SN - 1543-6136
AD - Matthieu, Monica M., Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, Campus Box 1196, St. Louis, MO, US, 63130
N1 - Accession Number: 2008-04851-006. PMID: 18340597 Partial author list: First Author & Affiliation: Matthieu, Monica M.; Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO, US. Other Publishers: Taylor & Francis. Release Date: 20080428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Matthieu, Monica M. Major Descriptor: At Risk Populations; Risk Factors; Suicide; Suicide Prevention; Training. Minor Descriptor: Military Veterans. Classification: Health & Mental Health Treatment & Prevention (3300); Military Psychology (3800). Population: Human (10). Location: US. Tests & Measures: Role Play Acceptability Scale; Peer Observational Checklist. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Mar, 2008.
AB - Clinical providers and 'front line' nonclinical staff who work with veterans, families, and communities are natural gatekeepers to identify and to refer veterans at risk for suicide. A national cohort (n = 602) of community based counseling center staff from the U.S. Department of Veterans Affairs (VA) participated in an evaluation of a brief standardized gatekeeper training program and a scripted behavioral rehearsal practice session. A significant difference in knowledge and self efficacy was observed from pre to post (p < .0001) with the nonclinicians showing larger effect sizes for knowledge (0.96 vs. 0.42) and self efficacy (0.89 vs. 0.41). Gatekeeper training for suicide prevention shows promise for increasing the capacity of VA staff to work with at risk veterans. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gatekeeper training
KW - suicide prevention
KW - at risk veterans
KW - 2008
KW - At Risk Populations
KW - Risk Factors
KW - Suicide
KW - Suicide Prevention
KW - Training
KW - Military Veterans
KW - 2008
U1 - Sponsor: National Institute of Mental Health. Grant: MH020061. Other Details: Institutional T32. Recipients: Matthieu, Monica M.; Conwell (Prin Inv)
U1 - Sponsor: National Institute of Mental Health. Grant: P20 MH071897. Other Details: Developing Center for Public Health and Population-Based Approaches to Suicide Prevention. Recipients: Caine (Prin Inv)
U1 - Sponsor: National Institute of Mental Health. Grant: KOI MH055317. Recipients: Knox, Kerry L.
DO - 10.1080/13811110701857491
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04851-006&site=ehost-live&scope=site
UR - mmatthieu@wusd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15250-005
AN - 2008-15250-005
AU - Bowyer, John F.
AU - Robinson, Bonnie
AU - Ali, Syed
AU - Schmued, Larry C.
T1 - Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure.
JF - Synapse
JO - Synapse
JA - Synapse
Y1 - 2008/03//
VL - 62
IS - 3
SP - 193
EP - 204
CY - US
PB - John Wiley & Sons
SN - 0887-4476
SN - 1098-2396
AD - Bowyer, John F., NCTR, HFT-132, Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2008-15250-005. PMID: 18081184 Partial author list: First Author & Affiliation: Bowyer, John F.; Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Blood Brain Barrier; Neurotoxins; Putamen; Tyrosine; Microglia. Minor Descriptor: Hydroxylases; Methamphetamine; Mice. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Mar, 2008.
AB - Changes in the histological morphology of the caudate-putamen (CPu) were determined after a high-dose methamphetamine (METH) exposure in an effort to elucidate whether BBB disruption plays a role in CPu neurotoxicity. This was accomplished by evaluating the tyrosine hydroxylase immunoreactivity (TH-IR), isolectin B4 reactivity, Black Gold II (BG-II) and Fluoro-Jade C (FJ-C) staining, and immunoreactivity to mouse immunoglobulin G (IgG-IR) in adult male mice at 90-min, 4-h, 12-h, 1-day, and 3-day post-METH exposure. The IgG-IR indicated that the BBB was only modestly altered in the CPu at time points after neurodegeneration occurred and dependent on hyperthermia and status epilepticus. The modest CPu IgG-IR changes observed in the perivascular areas indicated that immunoglobulins were present on some CPu microglia 1 day or more after METH. The first signs of CPu damage were swellings in the TH-IR axons, myelin damage, and a few degenerating neurons at 4-h post-METH. The loss of TH-IR was dependent on hyperthermia but not seizures or CPu neurodegeneration, and the TH-IR was virtually absent throughout the CPu within 12 h. Surprisingly, signs of FJ-C labeling (degenerating) axons in the CPu were seen only in the regions of pronounced somatic neurodegeneration and independent of TH-IR loss. Microglial activation did not occur until 1 day or more post-METH. In summary, a major BBB disruption within the CPu does not directly contribute to neurotoxicity in this single high-dose METH exposure. However, seizure activity produced or exacerbated by amygdalar BBB disruption can significantly increase CPu somatic neurodegeneration (but not affect dopamine (DA) terminal damage). The time course of microglial activation indicates a response to the neurodegeneration, myelin damage, and/or damaged DA terminals after loss of TH-IR. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurotoxin
KW - tyrosine hydroxylase
KW - microglia
KW - myelin
KW - blood brain barrier
KW - caudate-putamen
KW - methamphetamine
KW - 2008
KW - Blood Brain Barrier
KW - Neurotoxins
KW - Putamen
KW - Tyrosine
KW - Microglia
KW - Hydroxylases
KW - Methamphetamine
KW - Mice
KW - 2008
DO - 10.1002/syn.20478
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15250-005&site=ehost-live&scope=site
UR - john.bowyer@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05200-005
AN - 2008-05200-005
AU - Cook, Judith A.
AU - Blyler, Crystal R.
AU - Leff, H. Stephen
AU - McFarlane, William R.
AU - Goldberg, Richard W.
AU - Gold, Paul B.
AU - Mueser, Kim T.
AU - Shafer, Michael S.
AU - Onken, Steven J.
AU - Donegan, Kate
AU - Carey, Martha Ann
AU - Kaufmann, Caroline
AU - Razzano, Lisa A.
T1 - The Employment Intervention Demonstration Program: Major findings and policy implications.
T3 - Special 10th Anniversary Issue on Supported Employment
JF - Psychiatric Rehabilitation Journal
JO - Psychiatric Rehabilitation Journal
JA - Psychiatr Rehabil J
Y1 - 2008///Spr 2008
VL - 31
IS - 4
SP - 291
EP - 295
CY - US
PB - International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Health and Rehabilitation Services, Boston University
SN - 1095-158X
SN - 1559-3126
AD - Cook, Judith A., University of Illinois at Chicago, Department of Psychiatry, 601 West Taylor Street, 4th Floor M/C 912, Chicago, IL, US, 60612
N1 - Accession Number: 2008-05200-005. PMID: 18407877 Other Journal Title: Psychosocial Rehabilitation Journal. Partial author list: First Author & Affiliation: Cook, Judith A.; University of Illinois at Chicago, Chicago, IL, US. Other Publishers: Educational Publishing Foundation; International Association of Psychosocial Rehabilitation Services and Department of Rehabilitation Counseling, Sargent College of Allied Health Professions, Boston University. Release Date: 20080519. Correction Date: 20150803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Intervention; Mental Disorders; Supported Employment. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: Spr 2008.
AB - This article summarizes the published results of the Employment Intervention Demonstration Program (EIDP), a federally-funded, multi-site study examining the effectiveness of supported employment programs for 1,273 unemployed individuals with psychiatric disabilities in the U.S. Findings confirm the effectiveness of supported employment across different models, program locations, and participant populations. The study's results are discussed in the context of public policies designed to encourage return to work for those with a severe mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Employment Intervention Demonstration Program
KW - supported employment programs
KW - psychiatric disabilities
KW - 2008
KW - Intervention
KW - Mental Disorders
KW - Supported Employment
KW - 2008
U1 - Sponsor: US Department of Education, National Institute on Disability & Rehabilitation Research, US. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: Cooperative Agreement #H133B050003B. Recipients: No recipient indicated
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Employment Intervention Demonstration Program (EIDP), US. Grant: Cooperative Agreement SM51820. Other Details: Employment Intervention Demonstration Program (EIDP). Recipients: No recipient indicated
DO - 10.2975/31.4.2008.291.295
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05200-005&site=ehost-live&scope=site
UR - cook@ripco.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-03157-014
AN - 2008-03157-014
AU - Braun, M. Miles
T1 - Toward better vaccine safety data and Safer vaccination.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/03//
VL - 121
IS - 3
SP - 625
EP - 626
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Braun, M. Miles, Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-220, 1401 Rockville Pike, Rockville, MD, US, 20852
N1 - Accession Number: 2008-03157-014. PMID: 18310214 Partial author list: First Author & Affiliation: Braun, M. Miles; Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, US. Release Date: 20080616. Correction Date: 20100215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Comment/Reply. Language: English. Major Descriptor: Blood and Lymphatic Disorders; Immunization; Side Effects (Treatment). Minor Descriptor: Safety. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Mar, 2008.
AB - Comments on an article, 'The risk of immune thrombocytopenic purpura following measles-mumps-rubella immunization in children' by E. K. France et al. (2008). The authors found an attributable risk of 1 case of immune thrombocytopenic purpura (ITP) per 40 000 doses of MMR administered in the second year of life. Given that the annual US birth cohort is >4 million and that the first dose of MMR is routinely recommended by the Centers for Disease Control and Prevention (CDC) early in the second year of life, then ~100 cases of ITP per year would be attributable to MMR vaccination in the United States' setting of nearly universal immunization with this vaccine. Current evidence does not suggest substantial clinical differences between ITP after MMR vaccination and ITP due to other causes. ITP is frequently treated with corticosteroids and/or intravenous immunoglobulin, and then the condition usually resolves. Chronic ITP occurs in a small percentage of cases, 2 of 20 ITP cases post- MMR among children 12 to 23 months of age in the study. The study used data from the CDC's Vaccine Safety Datalink. This innovative project began in the early 1990s and is an invaluable and essential pillar of the US system to monitor the safety of licensed vaccines. The Vaccine Safety Datalink has also been an early adopter of powerful and clever novel analytic techniques. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - MMR vaccination
KW - safety
KW - thrombocytopenic purpura
KW - vaccines
KW - 2008
KW - Blood and Lymphatic Disorders
KW - Immunization
KW - Side Effects (Treatment)
KW - Safety
KW - 2008
DO - 10.1542/peds.2007-3846
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03157-014&site=ehost-live&scope=site
UR - miles.braun@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Hye-Kyung Park
T1 - Nutrition policy in South Korea.
JO - Asia Pacific Journal of Clinical Nutrition
JF - Asia Pacific Journal of Clinical Nutrition
Y1 - 2008/03/02/2008 Supplement 1
VL - 17
M3 - Article
SP - 343
EP - 345
SN - 09647058
AB - Since 1970s, the economic and social development in South Korea, as well as dietary pattern, has undergone various changes. Concerns for the decreased nutrition quality and physical activities among Koreans, especially young population, call for a need of a holistic approach in national food and nutrition policy. The National Health Promotion Act of 1995 included national interventions and programs to deal with nutrition-related chronic diseases and obesity prevention. A nation-wide monitoring system, which includes nutrition and health examination survey, is being built and run by the Ministry of Health and Welfare and its affiliated organizations every three years. The Korea Food and Drug Administration (KFDA) is another key agency undertaking national food and nutrition policies. The KFDA recently promulgated the national strategic plans for improving food safety and nutrition, focusing on children. Nutrition labelling policy for processed food is managed by KFDA and various education programs are developed and disseminated to enhance the awareness of nutrition labelling. The agency also makes standards and regulates foods for special dietary uses and health functional food. The Rural Development Administration (RDA) is responsible for maintaining the food composition database. Finally, the National School Lunch Program is mainly governed by the Ministry of Education and Human Resources Development. The above central government agencies along with regional health centers are making efforts to promote the healthy eating habits in addition to constructing healthy environment by making laws and programs and by research and social marketing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Asia Pacific Journal of Clinical Nutrition is the property of Asia Pacific Journal of Clinical Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUTRITION policy
KW - NUTRITION
KW - GOVERNMENT agencies
KW - FOOD
KW - KOREA (South)
KW - government intervention
KW - nutrition
KW - nutrition policy
KW - South Korea
N1 - Accession Number: 31268844; Hye-Kyung Park 1; Email Address: phkfda@kfda.go.kr; Affiliation: 1: Korea Food and Drug Administration, Nutrition Evaluation Team, Republic of Korea; Source Info: 2008 Supplement 1, Vol. 17, p343; Subject Term: NUTRITION policy; Subject Term: NUTRITION; Subject Term: GOVERNMENT agencies; Subject Term: FOOD; Subject Term: KOREA (South); Author-Supplied Keyword: government intervention; Author-Supplied Keyword: nutrition; Author-Supplied Keyword: nutrition policy; Author-Supplied Keyword: South Korea; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31268844&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ting-Kai Li
T1 - Quantifying the risk for alcohol-use and alcohol-attributable health disorders: Present findings and future research needs.
JO - Journal of Gastroenterology & Hepatology
JF - Journal of Gastroenterology & Hepatology
Y1 - 2008/03/02/Mar2008 Supplement 1
VL - 23
M3 - Article
SP - S2
EP - S8
PB - Wiley-Blackwell
SN - 08159319
AB - The aim of the present review was to: (i) highlight epidemiological and other studies that have generated important data on the harmful patterns of drinking that increase the risk for chronic diseases, including alcohol dependence, and on the mechanisms by which alcohol produces and, in some instances, may protect against damage; and (ii) discuss a conceptual basis for quantifying risk criteria for alcohol-induced chronic disease based on the quantity, frequency, and pattern of drinking. The relationship between heavy drinking and risk for adverse health conditions such as alcoholic liver disease (ALD), dementia, and alcohol dependence is well known. However, not everyone who drinks chronically develops ALD or dementia, and the major risk factors for disease development and the mechanisms by which this occurs have remained unclear. Large-scale, general population-based studies have provided the evidence by which quantifying the frequency of a pattern of high-risk drinking can be related directly to risk and the severity of alcohol dependence. Cellular and molecular biology studies have identified the major pathways of alcohol metabolism and how genetics and the environment can interact in some individuals to further increase the risk of organ damage. Extant databases should allow scientists and clinicians jointly to develop the framework for quantifying the drinking patterns that increase the risk of alcohol-induced organ pathologies, to develop clinical practice guidelines, such as those used to diagnose other common complex diseases (e.g. diabetes and hypertension), and to propose future studies for refining such guidelines. Attention must be paid to comorbid conditions such as hepatitis B and C infections, HIV, obesity, and environmental exposures other than alcohol. Developing trait and state biomarkers is critical to the process of discovery and to fulfilling the promise of personalized medicine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Gastroenterology & Hepatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRINKING of alcoholic beverages
KW - CHRONIC diseases
KW - DRINKING behavior
KW - ALCOHOLIC beverages
KW - GASTROENTEROLOGY
KW - alcohol
KW - alcohol organ damage
KW - alcohol-use disorder
KW - alcoholic liver disease
KW - binge drinking
N1 - Accession Number: 31228870; Ting-Kai Li 1; Email Address: tkli@mail.nih.gov; Affiliation: 1: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA; Source Info: Mar2008 Supplement 1, Vol. 23, pS2; Subject Term: DRINKING of alcoholic beverages; Subject Term: CHRONIC diseases; Subject Term: DRINKING behavior; Subject Term: ALCOHOLIC beverages; Subject Term: GASTROENTEROLOGY; Author-Supplied Keyword: alcohol; Author-Supplied Keyword: alcohol organ damage; Author-Supplied Keyword: alcohol-use disorder; Author-Supplied Keyword: alcoholic liver disease; Author-Supplied Keyword: binge drinking; NAICS/Industry Codes: 445310 Beer, Wine, and Liquor Stores; NAICS/Industry Codes: 424820 Wine and Distilled Alcoholic Beverage Merchant Wholesalers; NAICS/Industry Codes: 413220 Alcoholic beverage merchant wholesalers; NAICS/Industry Codes: 312140 Distilleries; NAICS/Industry Codes: 722410 Drinking Places (Alcoholic Beverages); Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1440-1746.2007.05298.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31228870&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fangjun Zhou
AU - Ortega-Sanchez, Ismael R.
AU - Guris, Dalya
AU - Shefer, Abigail
AU - Lieu, Tracy
AU - Seward, Jane F.
T1 - An Economic Analysis of the Universal Varicella Vaccination Program in the United States.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/03/02/Mar2008 Supplement 2
VL - 197
M3 - Article
SP - S156
EP - S164
SN - 00221899
AB - Frequent varicella outbreaks with sizable impact on the US public health system have continued to occur despite the success of the country's 1-dose varicella vaccination program. The Advisory Committee on Immunization Practices recently recommended adding a routine second dose of varicella vaccine and weighed economic projections as well as public health goals in their deliberations. This decision-tree-based analysis was conducted to evaluate the economic impact of the projected 2-dose varicella vaccination program as well as the existing 1-dose program. The analysis used population-based vaccination coverage and disease incidence data to make projections for a hypothetical US birth cohort of 4,100,000 infants born in 2006. Compared with no vaccination, both the 1-dose program (societal benefit-cost ratio [BCR], 4.37) and 2-dose program (BCR, 2.73) were estimated to be cost saving from the societal perspective. Compared with the 1-dose program, the incremental second dose was not cost saving (societal incremental BCR, 0.56). The incremental cost-effectiveness ratio for the second dose was $343 per case prevented, or ~$109,000 per quality-adjusted life-year saved, and these results were sensitive to assumptions about vaccine effectiveness and prices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VARICELLA-zoster virus
KW - PUBLIC health
KW - VIRAL vaccines
KW - IMMUNIZATION of children
KW - VACCINATION of children
KW - UNITED States
N1 - Accession Number: 31645388; Fangjun Zhou 1; Email Address: faz1@cdc.gov Ortega-Sanchez, Ismael R. 1 Guris, Dalya 1 Shefer, Abigail 1 Lieu, Tracy 2 Seward, Jane F. 1; Affiliation: 1: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 2: Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts; Source Info: Mar2008 Supplement 2, Vol. 197, pS156; Subject Term: VARICELLA-zoster virus; Subject Term: PUBLIC health; Subject Term: VIRAL vaccines; Subject Term: IMMUNIZATION of children; Subject Term: VACCINATION of children; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1086/522135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31645388&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chaves, Sandra S.
AU - Haber, Penina
AU - Walton, Kimp
AU - Wise, Robert P.
AU - Izurieta, Hector S.
AU - Schmid, D. Scott
AU - Seward, Jane F.
T1 - Safety of Varicella Vaccine after Licensure in the United States: Experience from Reports to the Vaccine Adverse Event Reporting System, 1995—2005.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/03/02/Mar2008 Supplement 2
VL - 197
M3 - Article
SP - S170
EP - S177
SN - 00221899
AB - Widespread use of varicella vaccine in the United States could enable detection of rare adverse events not identified previously. We reviewed data from 1995 to 2005 from the Vaccine Adverse Event Reporting System, including data from laboratory analyses, to distinguish adverse events associated with wild-type varicella-zoster virus (VZV) versus those associated with vaccine strain. Almost 48 million doses of varicella vaccine were distributed between 1995 and 2005. There were 25,306 adverse events reported (52.7/100,000 doses distributed); 5.0% were classified as serious (2.6/100,000 doses distributed). Adverse events associated with evidence of vaccine-strain VZV included meningitis in patients with concurrent herpes zoster. Patients with genetic predispositions may rarely have disease triggered by receipt of varicella vaccine. Overall, serious adverse events reported after varicella vaccination continue to be rare and must be considered relative to the substantial benefits of varicella vaccination. Ongoing safety surveillance and further studies may shed light on some of the hypothesized associations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL vaccines
KW - VARICELLA-zoster virus
KW - VACCINATION
KW - IMMUNIZATION
KW - SHINGLES (Disease)
KW - PUBLIC health surveillance
KW - EPIDEMIOLOGY
KW - UNITED States
N1 - Accession Number: 31645390; Chaves, Sandra S. 1; Email Address: schaves@cdc.gov Haber, Penina 1 Walton, Kimp 1 Wise, Robert P. 2 Izurieta, Hector S. 2 Schmid, D. Scott 1 Seward, Jane F. 1; Affiliation: 1: Centers for Disease Control and Prevention, Atlanta, Georgia 2: US Food and Drug Administration, Rockville, Maryland; Source Info: Mar2008 Supplement 2, Vol. 197, pS170; Subject Term: VIRAL vaccines; Subject Term: VARICELLA-zoster virus; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: SHINGLES (Disease); Subject Term: PUBLIC health surveillance; Subject Term: EPIDEMIOLOGY; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1086/522161
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gebbie, Kristine M.
AU - Hodge, James G.
AU - Meier, Benjamin Mason
AU - Barrett, Drue H.
AU - Keith, Priscilla
AU - Koo, Denise
AU - Sweeney, Patricia M.
AU - Winget, Patricia
T1 - Improving Competencies for Public Health Emergency Legal Preparedness.
JO - Journal of Law, Medicine & Ethics
JF - Journal of Law, Medicine & Ethics
Y1 - 2008/03/02/Spring2008 Supplement 1
VL - 36
M3 - Article
SP - 52
EP - 56
PB - Wiley-Blackwell
SN - 10731105
AB - A conference paper on the understanding of public health professionals, legal counsels and relevant partners regarding the application of legal authorities to public health emergency preparedness is presented. It describes the competencies in public health legal preparedness, and the development of public health emergency competencies. It discusses the public health law competencies and identifies the gaps which hinder the attainment of full legal preparedness for public health emergencies.
KW - MEDICAL emergencies -- Management
KW - PUBLIC health
KW - EMERGENCY management
KW - PUBLIC health laws
KW - MEDICAL laws & legislation
N1 - Accession Number: 35755391; Gebbie, Kristine M. 1 Hodge, James G. 2 Meier, Benjamin Mason 3 Barrett, Drue H. 4 Keith, Priscilla 5 Koo, Denise 6 Sweeney, Patricia M. 7 Winget, Patricia 8; Affiliation: 1: Elizabeth Standish Gill Associate Professor of Nursing and Director of the Doctor of Nursing Science at Columbia University School of Nursing; she is also the Director of the Center for Health Policy. 2: Associate Professor at Johns Hopkins Bloomberg School of Public Health; he is also the Executive Director of the Center for Law and the Public's Health. 3: Fellow at the Department of Sociomedical Sciences and Center for Health Policy at Columbia University. 4: Public Health Ethics Coordinator of the Office of the Chief Science Officer at the Centers for Disease Control and Prevention. 5: Chief Counsel at the Marion County Health and Hospital Corporation in Indiana. 6: Captain, U.S. Public Health Service, Director, Career Development Division, Office of Workforce and Career Development, CDC. 7: Co-Director of the Center for Public Health Practice and an Assistant Professor of the Graduate School of Public Health at the University of Pittsburgh. 8: Legal Counsel with the Office of the General Counsel, Minnesota Department of Health.; Source Info: Spring2008 Supplement 1, Vol. 36, p52; Subject Term: MEDICAL emergencies -- Management; Subject Term: PUBLIC health; Subject Term: EMERGENCY management; Subject Term: PUBLIC health laws; Subject Term: MEDICAL laws & legislation; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1748-720X.2008.00261.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wenmin Du
AU - Guo, Jeff J.
AU - Yonghua Jing
AU - Xing Li
AU - Kelton, Christina M. L.
T1 - Drug Safety Surveillance in China and Other Countries: A Review and Comparison.
JO - Value in Health
JF - Value in Health
Y1 - 2008/03/02/Mar2008 Supplement
VL - 11
M3 - Article
SP - S130
EP - S136
PB - Elsevier Science
SN - 15244733
AB - Objectives: Drug safety and postmarketing surveillance have become important public health issues in China. This study reviews the relatively new drug safety surveillance system in China and compares it with the systems in the United States and Europe. Methods: An extensive literature review was conducted in the following four areas: 1) the organizational structure of the State Food and Drug Administration (SFDA) in China; 2) the development of an adverse drug reaction (ADR) monitoring system in China; 3) regulatory issues related to drug safety in China; and 4) similarities and differences between drug safety surveillance in China and surveillance in the United States and Europe. Results: The SFDA oversees an extensive network of drug safety “watchdogs,” including the China National Center for ADR Monitoring and 32 regional centers throughout China. China's system has faced a number of recent challenges. It has had to respond quickly to the withdrawal of various high-profile drugs like Vioxx (rofecoxib) and Baycol (cerivastatin) from other markets. Together with China's Ministry of Health, the SFDA has faced several unique drug safety events. Three of those events, involving the injectable form of the heartleaf houttuyinia herb (Yu Xing Cao), Armillarisni A injections, and clindamycin glucose infusions (Xinfu), are discussed. The rapid development of drug safety surveillance in China is manifested in extensive organizational structure, development of large databases, and laws and regulations supporting drug safety. The two major laws are the China Drug Administration Law issued in February 2001 and the Regulation for the Administration of ADR Reporting and Monitoring issued in March 2004. The study also discusses and compares recent developments in drug safety surveillance in the United States and the European Union. These developments will most likely have implications for the Chinese system in the near future. Conclusions: While postmarketing surveillance guidelines are not yet available in China, we fully expect their eventual issuance after adaptation to the particular culture and clinical practices in China. [ABSTRACT FROM AUTHOR]
AB - Copyright of Value in Health is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Safety measures
KW - PUBLIC health
KW - PHARMACEUTICAL policy
KW - CHINA
KW - adverse drug reaction
KW - China
KW - drug safety
KW - surveillance
KW - CHINA. Wei sheng bu
N1 - Accession Number: 31681348; Wenmin Du 1 Guo, Jeff J. 2; Email Address: jeff.guo@uc.edu Yonghua Jing 2 Xing Li 2 Kelton, Christina M. L. 3; Affiliation: 1: Shanghai Center for Adverse Drug Reaction Monitoring, Shanghai Food and Drug Administration, Shanghai, China. 2: College of Pharmacy, University of Cincinnati Health Academic Center, Cincinnati, OH, USA. 3: College of Business, University of Cincinnati, Cincinnati, OH, USA.; Source Info: Mar2008 Supplement, Vol. 11, pS130; Subject Term: DRUGS -- Safety measures; Subject Term: PUBLIC health; Subject Term: PHARMACEUTICAL policy; Subject Term: CHINA; Author-Supplied Keyword: adverse drug reaction; Author-Supplied Keyword: China; Author-Supplied Keyword: drug safety; Author-Supplied Keyword: surveillance; Company/Entity: CHINA. Wei sheng bu; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1524-4733.2008.00377.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105770677
T1 - Drug safety surveillance in China and other countries: a review and comparison.
AU - Du W
AU - Guo JJ
AU - Jing Y
AU - Li X
AU - Kelton CML
Y1 - 2008/03/02/Mar2008 Supplement
N1 - Accession Number: 105770677. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Mar2008 Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100883818.
KW - Consumer Product Safety -- Legislation and Jurisprudence
KW - Drugs, Prescription -- Adverse Effects -- China
KW - Health Policy
KW - China
KW - Government Programs
KW - Medicine, Herbal -- Adverse Effects
SP - S130
EP - 6
JO - Value in Health
JF - Value in Health
JA - VALUE HEALTH
VL - 11
CY - New York, New York
PB - Elsevier Science
SN - 1524-4733
AD - Shanghai Center for Adverse Drug Reaction Monitoring, Shanghai Food and Drug Administration, Shanghai, China
U2 - PMID: 18387057.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yu-Chih Lo
AU - Maddineni, Upendra
AU - Chung, Jee Y.
AU - Rich, Rebecca L.
AU - Myszka, David G.
AU - Hao Wu
T1 - High-Affinity Interaction between IKKβ and NEMO.
JO - Biochemistry
JF - Biochemistry
Y1 - 2008/03/11/
VL - 47
IS - 10
M3 - Article
SP - 3109
EP - 3116
SN - 00062960
AB - The Ser/Thr-specific IκB kinase (IKK), which comprises IKKα or IKKβ and the regulatory protein NEMO, is at the bottleneck for NF-κB activation. IKK activity relies on interaction between NEMO and IKKα or IKKβ. A conserved region in the C-terminal tail of IKKβ or IKKα (NEMO-binding domain, NBD, residues 734-745 of IKKβ) is important for interaction with NEMO. Here we show that the NBD peptide of IKKβ is not sufficient for interaction with NEMO. Instead, a longer region of the IKKβ C-terminal region provides high affinity for NEMO. Quantitative measurements using surface plasmon resonance and isothermal titration calorimetry confirm the differential affinities of these interactions and provide insight into the kinetic and thermodynamic behaviors of the interactions. Biochemical characterization using multiangle light scattering (MALS) coupled with refractive index shows that the longer IKKβ C-terminal region forms a 2:2 stoichiometirc complex with NEMO. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMONS (Physics)
KW - LIGHT -- Scattering
KW - CALORIMETRY
KW - THERMODYNAMICS
KW - VOLUMETRIC analysis
KW - PROTEINS
N1 - Accession Number: 31682701; Yu-Chih Lo 1 Maddineni, Upendra 1,2 Chung, Jee Y. 1,3 Rich, Rebecca L. 4 Myszka, David G. 4 Hao Wu 1,2; Email Address: haowu@med.cornell.edu; Affiliation: 1: Department of Biochemistry, Weill Medical College of Cornell University 2: Tri-Institutional MD-PHD Program, New York, New York 10021 3: Department of Therapeutic Proteins, Center for Drug Evaluation and Rersearch, Food and Drug Administration, Bethesda, MD 20892 4: Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, Utah 84132; Source Info: 3/11/2008, Vol. 47 Issue 10, p3109; Subject Term: PLASMONS (Physics); Subject Term: LIGHT -- Scattering; Subject Term: CALORIMETRY; Subject Term: THERMODYNAMICS; Subject Term: VOLUMETRIC analysis; Subject Term: PROTEINS; Number of Pages: 8p; Illustrations: 4 Black and White Photographs, 1 Diagram, 3 Charts, 9 Graphs; Document Type: Article
L3 - 10.1021/bi702312c
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor, Allen D.
AU - Ladd, Jon
AU - Etheridge, Stacey
AU - Deeds, Jonathan
AU - Hall, Sherwood
AU - Jiang, Shaoyi
T1 - Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor
JO - Sensors & Actuators B: Chemical
JF - Sensors & Actuators B: Chemical
Y1 - 2008/03/14/
VL - 130
IS - 1
M3 - Article
SP - 120
EP - 128
SN - 09254005
AB - Abstract: We report the quantitative antibody-based detection of a low-molecular weight molecule tetrodotoxin (TTX) (∼319Da) by inhibition assay with a surface plasmon resonance (SPR) sensor. A novel anti-TTX antibody sensing surface was developed by chemically immobilizing TTX on a gold film with a mixed self assembled monolayer (SAM) consisting of amine terminated oligo-ethylene glycol (OEG) alkanethiol and a hydroxyl terminated OEG alkanethiol. The ratio of amine to hydroxyl terminated OEG alkanethiols and TTX immobilization chemistry were optimized to maximize specific anti-TTX binding, while minimizing non-specific binding. The calibration curves are reported for two antibody concentrations incubated with samples of varying TTX concentrations ranging from 0.01 to 10,000ng/mL. The detection limit for TTX is defined as IC20 (20% inhibitory concentration), which is ∼0.3ng/mL in this work. The corresponding calibration curve has a characteristic IC50 (50% inhibitory concentration) of ∼6ng/mL. The ability to reproducibly regenerate the TTX-immobilized surface was also demonstrated. [Copyright &y& Elsevier]
AB - Copyright of Sensors & Actuators B: Chemical is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MARINE toxins
KW - ATTENTION
KW - THOUGHT & thinking
KW - AROUSAL (Physiology)
KW - Antibody inhibition assay
KW - Neurotoxin
KW - Pufferfish
KW - Seafood toxin
KW - Surface plasmon resonance (SPR)
KW - Tetrodotoxin (TTX)
N1 - Accession Number: 31304009; Taylor, Allen D. 1 Ladd, Jon 1 Etheridge, Stacey 2; Email Address: stacey.etheridge@fda.hhs.gov Deeds, Jonathan 2 Hall, Sherwood 2 Jiang, Shaoyi 1; Email Address: sjiang@u.washington.edu; Affiliation: 1: Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195, USA 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA; Source Info: Mar2008, Vol. 130 Issue 1, p120; Subject Term: MARINE toxins; Subject Term: ATTENTION; Subject Term: THOUGHT & thinking; Subject Term: AROUSAL (Physiology); Author-Supplied Keyword: Antibody inhibition assay; Author-Supplied Keyword: Neurotoxin; Author-Supplied Keyword: Pufferfish; Author-Supplied Keyword: Seafood toxin; Author-Supplied Keyword: Surface plasmon resonance (SPR); Author-Supplied Keyword: Tetrodotoxin (TTX); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.snb.2007.07.136
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105744465
T1 - USPSTF recommendations for STI screening.
AU - Meyers D
AU - Wolff T
AU - Gregory K
AU - Marion L
AU - Moyer V
AU - Nelson H
AU - Petitti D
AU - Sawaya GF
Y1 - 2008/03/15/
N1 - Accession Number: 105744465. Language: English. Entry Date: 20080620. Revision Date: 20150711. Publication Type: Journal Article; CEU; questions and answers; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Health Screening -- Methods
KW - Sexually Transmitted Diseases -- Diagnosis
KW - United States Preventive Services Task Force -- Standards
KW - Education, Continuing (Credit)
KW - Expectant Mothers
KW - Female
KW - Male
KW - Risk Factors
KW - Sexually Transmitted Diseases -- Prevention and Control
KW - Sexually Transmitted Diseases -- Therapy
SP - 819
EP - 824
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 77
IS - 6
CY - Skokie, Illinois
PB - American Academy of Family Physicians
AB - Since 2000, the U.S. Preventive Services Task Force (USPSTF) has issued eight clinical recommendation statements on screening for sexually transmitted infections. This article, written on behalf of the USPSTF, is an overview of these recommendations. The USPSTF recommends that women at increased risk of infection be screened for chlamydia, gonorrhea, human immunodeficiency virus, and syphilis. Men at increased risk should be screened for human immunoodeficiency virus and syphilis. All pregnant women should be screened for hepatitis B, human immunodeficiency virus, and syphilis; pregnant women at increased risk also should be screened for chlamydia and gonorrhea. Nonpregnant women and men not at increased risk do not require routine screening for sexually transmitted infections. Engaging in high-risk sexual behavior places persons at increased risk of sexually transmitted infections. The USPSTF recommends that all sexually active women younger than 25 years be considered at increased risk of chlamydia and gonorrhea. Because not all communities present equal risk of sexually transmitted infections, the USPSTF encourages physicians to consider expanding or limiting the routine sexually transmitted infection screening they provide based on the community and populations they serve.
SN - 0002-838X
AD - Agency for Healthcare Research and Quality Center for Primary Care, Prevention, and Clinical Partnerships, Rockville, MD
U2 - PMID: 18386598.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gordon, Katrina V.
AU - Vickery, Michael C.
AU - DePaola, Angelo
AU - Staley, Christopher
AU - Harwood, Valerie J.
T1 - Real-Time PCR Assays for Quantification and Differentiation of Vibrio vulnificus Strains in Oysters and Water.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/03/15/
VL - 74
IS - 6
M3 - Article
SP - 1704
EP - 1709
SN - 00992240
AB - Vibrio vulnificus is an autochthonous estuarine bacterium and a pathogen that is frequently transmitted via raw shellfish. Septicemia can occur within 24 h; however, isolation and confirmation from water and oysters require days. Real-time PCR assays were developed to detect and differentiate two 16S rRNA variants, types A and B, which were previously associated with environmental sources and clinical fatalities, respectively. Both assays could detect 10² to 10³ V. vulnificus total cells in seeded estuarine water and in oyster homogenates. PCR assays on 11 reference V. vulnificus strains and 22 nontarget species gave expected results (type A or B for V. vulnificus and negative for nontarget species). The relationship between cell number and cycle threshold for the assays was linear (R² = >0.93). The type A/B ratio of Florida clinical isolates was compared to that of isolates from oysters harvested in Florida waters. This ratio was 19:17 in clinical isolates and 5:8 (n = 26) in oysters harvested from restricted sites with poor water quality but was 10:1 (n = 22) in oysters from permitted sites with good water quality. A substantial percentage of isolates from oysters (19.4%) were type 413 (both primer sets amplified), but no isolates from overlying waters were type AB. The real-time PCR assays were sensitive, specific, and quantitative in water samples and could also differentiate the strains in oysters without requiring isolation of V. vulnificus and may therefore be useful for rapid detection of the pathogen in shellfish and water, as well as further investigation of its population dynamics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO vulnificus
KW - OYSTERS
KW - RESEARCH
KW - SEPTICEMIA
KW - VIBRIO
KW - AQUATIC invertebrates
KW - SHELLFISH -- Microbiology
KW - AQUATIC microbiology
KW - FLORIDA
KW - UNITED States
N1 - Accession Number: 31609141; Gordon, Katrina V. 1 Vickery, Michael C. 2 DePaola, Angelo 3 Staley, Christopher 1 Harwood, Valerie J. 1; Email Address: vharwood@cas.usf.edu; Affiliation: 1: Department of Biology, University of South Florida, Tampa, Florida 33620 2: BioGX, Inc., Birmingham, Alabama 352032 3: Gulf Coast Seafood Laboratoty, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528; Source Info: Mar2008, Vol. 74 Issue 6, p1704; Subject Term: VIBRIO vulnificus; Subject Term: OYSTERS; Subject Term: RESEARCH; Subject Term: SEPTICEMIA; Subject Term: VIBRIO; Subject Term: AQUATIC invertebrates; Subject Term: SHELLFISH -- Microbiology; Subject Term: AQUATIC microbiology; Subject Term: FLORIDA; Subject Term: UNITED States; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1128/AEM.01100-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Agrawal, Anoop
AU - Cronin, John P.
AU - Agrawal, Akshay
AU - Tonazzi, Juan C. L.
AU - Adams, Lori
AU - Ashley, Kevin
AU - Brisson, Michael J.
AU - Duran, Brandy
AU - Whitney, Gary
AU - Burrell, Anthony K.
AU - McCleskey, T. Mark
AU - Robbins, James
AU - White, Kenneth T.
T1 - Extraction and Optical Fluorescence Method for the Measurement of Trace Beryllium in Soils.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2008/03/15/
VL - 42
IS - 6
M3 - Article
SP - 2066
EP - 2071
SN - 0013936X
AB - Beryllium metal and beryllium oxide are important industrial materials used in a variety of applications in the electronics, nuclear energy, and aerospace industries. These materials are highly toxic, they must be disposed of with care, and exposed workers need to be protected. Recently, a new analytical method was developed that uses dilute ammonium bifluoride for extraction of beryllium and a high quantum yield optical fluorescence reagent to determine trace amounts of beryllium in airborne and surface samples. The sample preparation and analysis procedure was published by both ASTM International and the National Institute for Occupational Safety and Health (NIOSH). The main advantages of this method are its sensitivity, simplicity, use of lower toxicity materials, and low capital costs. Use of the technique for analyzing soils has been initiated to help meet a need at several of the U.S. Department of Energy legacy sites. So far this work has mainly concentrated on developing a dissolution protocol for effectively extracting beryllium from a variety of soils and sediments so that these can be analyzed by optical fluorescence. Certified reference materials (CRM) of crushed rock and soils were analyzed for beryllium content using fluorescence, and results agree quantitatively with reference values. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Extraction (Chemistry)
KW - Beryllium oxide
KW - Fluorescence
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 31472848; Agrawal, Anoop 1; Email Address: aagrawal@qwest.net; Cronin, John P. 1; Agrawal, Akshay 1; Tonazzi, Juan C. L. 1; Adams, Lori 1; Ashley, Kevin 2; Brisson, Michael J. 3; Duran, Brandy 4; Whitney, Gary 4; Burrell, Anthony K. 4; McCleskey, T. Mark 4; Robbins, James 5; White, Kenneth T. 6; Affiliations: 1: Berylliant, Inc., 4541 East Fort Lowell Road, Tucson, Arizona 85712; 2: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Cincinnati, Ohio 45226; 3: Washington Savannah River Company, Savannah River Site, Aiken, South Carolina 29808; 4: Los Alamos National Laboratory, Los Alamos, New Mexico 87545; 5: National Energy Technology Laboratory, Albany, Oregon 97321; 6: Consultive Services, Virginia Beach, Virginia 23462; Issue Info: 3/15/2008, Vol. 42 Issue 6, p2066; Thesaurus Term: Beryllium; Thesaurus Term: Extraction (Chemistry); Subject Term: Beryllium oxide; Subject Term: Fluorescence ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1021/es702481h
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Strikas, Raymond A.
AU - Neff, Linda J.
AU - Rotz, Lisa
AU - Cono, Joanne
AU - Knutson, Donna
AU - Henderson, Joseph
AU - Orenstein, Walter A.
T1 - US Civilian Smallpox Preparedness and Response Program, 2003.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/03/16/3/15/2008 Supplement
VL - 46
M3 - Article
SP - S157
EP - S167
SN - 10584838
AB - Variola virus, the cause of smallpox disease, has been deemed a possible bioterrorism agent. Since November 2001, federal, state, and local public health partners implemented activities to prepare for a possible smallpox outbreak. The Centers for Disease Control and Prevention (CDC) produced and delivered training and educational materials for smallpox preparedness in many formats, developed detailed smallpox vaccine information statements about vaccine contraindications and vaccination site care, and established mechanisms to monitor and respond to adverse events after smallpox vaccination. The last included enhancements to the Vaccine Adverse Event Reporting System, a pregnancy registry for inadvertently vaccinated pregnant women, and a Clinician Telephone Information Line to collect reports about adverse events. The civilian responder vaccination program was conducted with rigorous safety procedures, and few historically recognized adverse events were observed. However, myocarditis and/or pericarditis was newly recognized as an adverse event caused by the New York City Board of Health vaccinia vaccine strain. This smallpox preparedness program put into place a number of measures to advance the United States' readiness for a smallpox outbreak that have assisted in preparedness for other threats. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Communicable diseases
KW - Smallpox -- Prevention
KW - Smallpox
KW - Poxvirus diseases
KW - Smallpox -- Government policy
KW - Preventive medicine
KW - United States
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 31586391; Strikas, Raymond A. 1; Email Address: Raymond.Strikas@psc.hhs.gov; Neff, Linda J. 2; Rotz, Lisa 2; Cono, Joanne 2; Knutson, Donna 2; Henderson, Joseph 2; Orenstein, Walter A. 3; Affiliations: 1: National Vaccine Program Office, US Department of Health and Human Services, Washington, DC.; 2: Centers for Disease Control and Prevention, Atlanta, Georgia; 3: Emory University School of Medicine, Atlanta, Georgia; Issue Info: 3/15/2008 Supplement, Vol. 46, pS157; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Thesaurus Term: Communicable diseases; Subject Term: Smallpox -- Prevention; Subject Term: Smallpox; Subject Term: Poxvirus diseases; Subject Term: Smallpox -- Government policy; Subject Term: Preventive medicine; Subject: United States ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1086/524751
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, Mei-Ling
T1 - Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2008/03/17/
VL - 60
IS - 6
M3 - Article
SP - 768
EP - 777
SN - 0169409X
AB - Abstract: The use of lipid-based dosage forms for enhancement of drug absorption or delivery has drawn considerable interest from pharmaceutical scientists. The unique characteristics of these dosage forms, however, present significant challenges to pharmaceutical industry and regulatory agencies in many ways. For example, safety assessment is necessary when the use of a new lipid excipient is considered. An important question for lipid formulation is whether the drug remains in solubilised form along the gastrointestinal (GI) tract after it is administered. Certain lipid excipients and surfactants have been reported to change intestinal permeability or interfere with enzyme/transporter activity, thereby affecting drug bioavailability. The potential influence of biopharmaceutical and/or pathophysiological factors on the drug or lipid excipient(s) needs to be explored. For a complex lipid-based dosage form, the conventional in vitro dissolution methods may not be appropriate for predicting in vivo performance in view of the convoluted GI processing of the lipid vehicle and formulation Of paramount importance is to identify any gaps in the scientific understanding of lipid-based dosage forms so that regulatory issues can be addressed. More mechanistic studies should be encouraged to facilitate a better understanding of the pharmaceutical characteristics of lipid formulations and complex interactions between lipid excipient, drug and physiological environment. This review discusses some regulatory considerations in the use of lipid excipients and delivery systems for pharmaceutical development. Implications in the regulatory determination of pharmaceutical equivalence, bioequivalence and therapeutic equivalence are also illustrated. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - STABILIZING agents
KW - PHARMACEUTICAL industry
KW - PHARMACEUTICAL services
KW - Bioequivalence
KW - Food and Drug Administration
KW - In vitro release
KW - Lipid-based dosage form
KW - Lipid-based formulation
KW - Liposome
KW - Modified release
KW - Pharmaceutical equivalence
KW - Therapeutic equivalence
N1 - Accession Number: 29957588; Chen, Mei-Ling 1; Email Address: meiling.chen@fda.hhs.gov; Affiliation: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration 10903 New Hampshire Avenue, Building 21, Room. 3508 Silver Spring, MD 20993-0002, USA; Source Info: Mar2008, Vol. 60 Issue 6, p768; Subject Term: DRUGS; Subject Term: STABILIZING agents; Subject Term: PHARMACEUTICAL industry; Subject Term: PHARMACEUTICAL services; Author-Supplied Keyword: Bioequivalence; Author-Supplied Keyword: Food and Drug Administration; Author-Supplied Keyword: In vitro release; Author-Supplied Keyword: Lipid-based dosage form; Author-Supplied Keyword: Lipid-based formulation; Author-Supplied Keyword: Liposome; Author-Supplied Keyword: Modified release; Author-Supplied Keyword: Pharmaceutical equivalence; Author-Supplied Keyword: Therapeutic equivalence; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.addr.2007.09.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Southworth, Mary Ross
AU - Kortepeter, Cindy
AU - Hughes, Alice
T1 - Nonbenzodiazepine Hypnotic Use and Cases of "Sleep Driving".
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/03/18/
VL - 148
IS - 6
M3 - Article
SP - 486
EP - 487
SN - 00034819
AB - The article reports on issues related to a study concerned with the cases of sleep driving associated with the use of the nonbenzodiazepine hypnotics. Researchers worked on the U.S. Food and Drug Administration (FDA) Adverse Events Reporting System for postmarketing reports of sleep driving associated with zolpidem, zaleplon, and eszopiclone. They concluded that the use of nonbenzodiazepine hypnotics, most notably zolpidem and zaleplon, may be associated with sleep driving.
KW - SLEEP disorders
KW - HYPNOTICS
KW - CENTRAL nervous system depressants
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31322783; Southworth, Mary Ross 1 Kortepeter, Cindy 1 Hughes, Alice 1; Affiliation: 1: U.S. Food and Drug Administration, Silver Spring, MD 20993.; Source Info: 3/18/2008, Vol. 148 Issue 6, p486; Subject Term: SLEEP disorders; Subject Term: HYPNOTICS; Subject Term: CENTRAL nervous system depressants; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hellinger, Fred J.
T1 - Medicare's Quality Improvement Organization Program: Maximizing Potential.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/03/18/
VL - 148
IS - 6
M3 - Book Review
SP - 488
EP - 488
SN - 00034819
AB - The article reviews the book "Medicare's Quality Improvement Organization Program: Maximizing Potential," by the U.S. Institute of Medicine.
KW - MEDICARE
KW - MEDICAL care -- Quality control
KW - NONFICTION
KW - MEDICARE'S Quality Improvement Organization Program: Maximizing Potential (Book)
N1 - Accession Number: 31322784; Hellinger, Fred J. 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland.; Source Info: 3/18/2008, Vol. 148 Issue 6, p488; Subject Term: MEDICARE; Subject Term: MEDICAL care -- Quality control; Subject Term: NONFICTION; Reviews & Products: MEDICARE'S Quality Improvement Organization Program: Maximizing Potential (Book); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 2/3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goodsaid, Federico M.
AU - Frueh, Felix W.
AU - Mattes, William
T1 - Strategic paths for biomarker qualification
JO - Toxicology
JF - Toxicology
Y1 - 2008/03/20/
VL - 245
IS - 3
M3 - Article
SP - 219
EP - 223
SN - 0300483X
AB - Abstract: Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end of discussions in the scientific literature as an indication that a biomarker has been accepted. An active approach to qualification requires development of a comprehensive process by which a consensus may be reached about the qualification of a biomarker. Active strategies for qualification include those associated with context-independent as well as context-dependent qualifications. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - BIOCHEMICAL genetics
KW - BIOINDICATORS
KW - BIOCHEMISTRY
KW - Biomarkers
KW - Consortia
N1 - Accession Number: 30842242; Goodsaid, Federico M. 1; Email Address: Federico.Goodsaid@fda.hhs.gov Frueh, Felix W. 1 Mattes, William 2; Affiliation: 1: Genomics Group, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, FDA, United States 2: Critical Path Institute; Source Info: Mar2008, Vol. 245 Issue 3, p219; Subject Term: BIOCHEMICAL markers; Subject Term: BIOCHEMICAL genetics; Subject Term: BIOINDICATORS; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Consortia; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.tox.2007.12.023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuanyuan Qiu
AU - Lynch, Jeffrey
AU - Lei Guo
AU - Yatsula, Bogdan
AU - Perkins, Archibald S.
AU - Michaiak, Marek
T1 - Regulation of the Calreticulin Gene by GATA6 and Evi-1 Transcription Factors.
JO - Biochemistry
JF - Biochemistry
Y1 - 2008/03/25/
VL - 47
IS - 12
M3 - Article
SP - 3697
EP - 3704
SN - 00062960
AB - Calreticulin is a Ca2+-buffering chaperone of the endoplasmic reticulum. The protein is highly expressed in embryonic heart but downregulated in postnatal heart, indicating that expression of calreticulin in the heart is highly regulated. In this study we identify GATA6 and Evi-1 transcription factors as new regulators of the calreticulin gene. In neonatal rat ventricular cardiomyocytes and mouse fibroblasts the calreticulin gene is activated by GATA6 but repressed by Evi-1. Furthermore, transactivation of the calreticulin gene by GATA6 is suppressed by Evi-1, suggesting an antagonistic role between both GATA6 and Evi-1. Using EMSA, ChIP analysis, and site-specific mutagenesis, we showed that GATA6 and Evi-1 bind to site 1 on the calreticulin promoter. GATA6 and Evi-1 are highly expressed early during cardiogenesis of ES cells, suggesting that they may regulate expression of the calreticulin gene during cardiac development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALRETICULIN
KW - ENDOPLASMIC reticulum
KW - PROTEINS
KW - FIBROBLASTS
KW - MUTAGENESIS
KW - MUTATION (Biology)
N1 - Accession Number: 31546704; Yuanyuan Qiu 1 Lynch, Jeffrey 1,2 Lei Guo 1,3 Yatsula, Bogdan 4 Perkins, Archibald S. 4 Michaiak, Marek 1; Email Address: Marek.Michalak@ualberta.ca; Affiliation: 1: Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7 2: Department of Pathology, Yale University, New Haven, Connecticut 06520 3: Division of Molecular Cardiovascular Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 4: Hepatic Toxicology, National Center for Toxico- logical Research, Food and Drug Administration, Jefferson, AR 72079; Source Info: 3/25/2008, Vol. 47 Issue 12, p3697; Subject Term: CALRETICULIN; Subject Term: ENDOPLASMIC reticulum; Subject Term: PROTEINS; Subject Term: FIBROBLASTS; Subject Term: MUTAGENESIS; Subject Term: MUTATION (Biology); Number of Pages: 8p; Illustrations: 4 Black and White Photographs, 2 Diagrams, 11 Graphs; Document Type: Article
L3 - 10.1021/bi702524v
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - X. Xu
AU - Q. Xie
AU - Y. Shen
AU - J. Jiang
AU - Y. Chen
AU - H. Yao
AU - J. Zhou
T1 - Mannose prevents lipopolysaccharide-induced acute lung injury in rats.
JO - Inflammation Research
JF - Inflammation Research
Y1 - 2008/03/28/
VL - 57
IS - 3
M3 - Article
SP - 104
EP - 110
SN - 10233830
AB - Abstract. Objective: To investigate the effect of mannose on lipopolysaccharide (LPS) induced acute lung injury (ALI) in rats. Methods: Ten groups of Sprague–Dawley rats were used: 1) the control group received an intratracheal instillation of saline, 2) the LPS group received an intratracheal instillation of LPS (3 mg/kg), 3–6) the mannose groups were injected i.v. with 15, 45, 135, and 405 mg/kg mannose, 7–9) the glucose, galactose, and fructose groups were injected with different hexoses (135 mg/kg), and 10) the dexamethasone (DXM) group was injected with DXM (2 mg/kg). In groups 2–8, LPS was administered after injection of drugs. Lung wet/dry weight ratio, permeability index (PPI), total leukocytes and polymorphonuclear neutrophils (PMNs) counts in bronchoalveolar lavage fluid (BALF), myeloperoxidase (MPO) and superoxide dismutase (SOD) activity, tumor necrosis factor (TNF)-α and interleukin (IL)-10 in lung and BALF were determined. Results: Pre-treatment with mannose attenuated pulmonary edema and protein exudation in a dose-dependent manner, the maximal effect was similar to or greater than that of DXM. Mannose also prevented the inflammatory cell accumulation, although the maximal effect was weaker than that of DXM. Mannose was more effective than DXM in inhibiting MPO activity and restoring SOD activity. Moreover, it inhibited production of TNF-α and IL-10. Histological changes of the lungs were also ameliorated by mannose. There were no significant improvements observed in rats pre-treated with glucose, galactose or fructose. Conclusions: Mannose is effective in reducing LPS-induced ALI. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inflammation Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MANNOSE
KW - MONOSACCHARIDES
KW - ENDOTOXINS
KW - LUNGS -- Wounds & injuries
N1 - Accession Number: 32608319; X. Xu 1 Q. Xie 2 Y. Shen 1 J. Jiang 1 Y. Chen 1 H. Yao 2 J. Zhou 1; Affiliation: 1: First Affiliated Hospital, Medical College of Zhejiang University Department of Respiratory Medicine Hangzhou 310003 China 2: Medical College of Zhejiang University Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration Hangzhou 310058 China; Source Info: Mar2008, Vol. 57 Issue 3, p104; Subject Term: MANNOSE; Subject Term: MONOSACCHARIDES; Subject Term: ENDOTOXINS; Subject Term: LUNGS -- Wounds & injuries; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pal, Gopalendu
AU - Dutta, Ashim
AU - Mitra, Kunal
AU - Grace, Michael S.
AU - Romanczyk, Tara B.
AU - Wu, Xingjia
AU - Chakrabarti, Kristi
AU - Anders, Juanita
AU - Gorman, Erik
AU - Waynant, Ronald W.
AU - Tata, Darrell B.
T1 - Corrigendum to: “Effect of low intensity laser interaction with human skin fibroblast cells using fiber-optic nano-probes” [J. Photochem. Photobiol. B: Biol. 86 (2007) 252–261]
JO - Journal of Photochemistry & Photobiology B: Biology
JF - Journal of Photochemistry & Photobiology B: Biology
Y1 - 2008/03/28/
VL - 90
IS - 3
M3 - Correction notice
SP - 207
EP - 207
SN - 10111344
N1 - Accession Number: 31304726; Pal, Gopalendu 1 Dutta, Ashim 1 Mitra, Kunal 1; Email Address: kmitra@fit.edu Grace, Michael S. 2 Romanczyk, Tara B. 3 Wu, Xingjia 3 Chakrabarti, Kristi 3,4 Anders, Juanita 3 Gorman, Erik 4 Waynant, Ronald W. 4 Tata, Darrell B. 4; Affiliation: 1: Department of Mechanical and Aerospace Engineering, Florida Institute of Technology, 150 W University Blvd, Melbourne, FL 32901, United States 2: Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901, United States 3: Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States 4: Food and Drug Administration, Rockville, MD 20857, United States; Source Info: Mar2008, Vol. 90 Issue 3, p207; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.jphotobiol.2006.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yuan-Zhi Wang
AU - Ming-Dong Wang
AU - Yun-Peng Diao
AU - Qian Cai
T1 - N'-(4-Methoxybenzylidene)-4-nitrobenzohydrazide methanol solvate.
JO - Acta Crystallographica: Section E (International Union of Crystallography - IUCr)
JF - Acta Crystallographica: Section E (International Union of Crystallography - IUCr)
Y1 - 2008/04//
VL - 64
IS - 4
M3 - Article
SP - o668
EP - o668
SN - 16005368
AB - The article presents a report on the molecular structure of the compound called N'-(4-Methoxybenzylidene)-4-nitrobenzohydrazide methanol solvate. It states that a reaction of 4-methoxybenzaldehyde with 4-nitrobenzohydrazide in methanol is where the compound was synthesized. It mentions that a research grant from Dalian Medical University in China has provided support for this project.
KW - MOLECULAR structure
KW - METHANOL
KW - RESEARCH grants
KW - UNIVERSITIES & colleges
KW - CHEMISTRY
KW - CHINA
KW - data-to-parameter ratio = 15.0
KW - mean σ(C-C) = 0.004 Å
KW - R factor = 0.058
KW - single-crystal X-ray study
KW - T = 298 K
KW - wR factor = 0.172
N1 - Accession Number: 34688516; Yuan-Zhi Wang 1,2 Ming-Dong Wang 2 Yun-Peng Diao 3; Email Address: diaoyiwen@126.com Qian Cai 1; Email Address: caiqianmail@sina.com; Affiliation: 1: Liaoning University of Traditional Chinese Medicine, Shenyang 110032, People's Republic of China 2: Liaoning Food and Drug Administration, Shenyang 110003, People's Republic of China 3: School of Pharmacy, Dalian Medical University, Dalian 116044, People's Republic of China; Source Info: Apr2008, Vol. 64 Issue 4, po668; Subject Term: MOLECULAR structure; Subject Term: METHANOL; Subject Term: RESEARCH grants; Subject Term: UNIVERSITIES & colleges; Subject Term: CHEMISTRY; Subject Term: CHINA; Author-Supplied Keyword: data-to-parameter ratio = 15.0; Author-Supplied Keyword: mean σ(C-C) = 0.004 Å; Author-Supplied Keyword: R factor = 0.058; Author-Supplied Keyword: single-crystal X-ray study; Author-Supplied Keyword: T = 298 K; Author-Supplied Keyword: wR factor = 0.172; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 813219 Other Grantmaking and Giving Services; NAICS/Industry Codes: 611310 Colleges, Universities, and Professional Schools; Number of Pages: 1p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1107/S1600536808005813
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nelson, Robert M.
T1 - Institutional Review Boards Lack the Moral Legitimacy to Reinterpret Subpart D.
JO - American Journal of Bioethics
JF - American Journal of Bioethics
Y1 - 2008/04//
VL - 8
IS - 4
M3 - Article
SP - 37
EP - 39
PB - Routledge
SN - 15265161
AB - Commentaries on the paper "A plea for pragmatism in clinical research ethics," by D.H. Brendel and F.G. Miller, published in the Volume 8 of the "American Journal of Bioethics" are presented. It argues that Miller and Brendel have proposed a pragmatic approach to clinical research ethics in which moral rules and principles function hypothetically within the process of moral problem-solving.
KW - PRAGMATISM
KW - BIOETHICS
KW - RESEARCH -- Moral & ethical aspects
KW - ETHICS
KW - MEDICAL research
N1 - Accession Number: 32771148; Nelson, Robert M. 1; Email Address: Robert.Nelson@fda.hhs.gov; Affiliation: 1: United States Food and Drug Administration; Source Info: Apr2008, Vol. 8 Issue 4, p37; Subject Term: PRAGMATISM; Subject Term: BIOETHICS; Subject Term: RESEARCH -- Moral & ethical aspects; Subject Term: ETHICS; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1080/15265160802147264
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Attfield, M.D.
AU - Kuempel, E.D.
T1 - Mortality Among U.S. Underground Coal Mines: A 23-Year Follow-Up.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/04//
VL - 51
IS - 4
M3 - Article
SP - 231
EP - 245
SN - 02713586
AB - The article presents a study on mortality among underground coal miners in the United States. It examines the mortality experience of 8,899 coal miners working at 31 coal mines in the United States from 1969-1971. The experiences of these coal miners are for over 22-24 years from the time of the study. Researchers focused on accidents, nonmalignant respiratopry diseases (NMRD) and nonviolent factors as causes of death and their elevated mortality rate. Results indicate that there is no increase in mortality caused by stomach cancer and lung cancer. Moreover, it was also proven that coal mine dust exposure is a factor that increases mortality among coal miners.
KW - Coal mines & mining
KW - Occupational diseases
KW - Dust
KW - Air pollution
KW - Mortality
KW - Coal miners
KW - Death
KW - Respiratory diseases
KW - United States
KW - coal
KW - dust
KW - exposure-response
KW - mortality
KW - pneumoconiosis
N1 - Accession Number: 31420688; Attfield, M.D. 1; Email Address: mdal@cdc.gov-t; Kuempel, E.D. 2; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia; 2: Education and Information Division, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio; Issue Info: Apr2008, Vol. 51 Issue 4, p231; Thesaurus Term: Coal mines & mining; Thesaurus Term: Occupational diseases; Thesaurus Term: Dust; Thesaurus Term: Air pollution; Subject Term: Mortality; Subject Term: Coal miners; Subject Term: Death; Subject Term: Respiratory diseases; Subject: United States; Author-Supplied Keyword: coal; Author-Supplied Keyword: dust; Author-Supplied Keyword: exposure-response; Author-Supplied Keyword: mortality; Author-Supplied Keyword: pneumoconiosis; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); Number of Pages: 15p; Illustrations: 1 Diagram, 11 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/ajim.20560
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lin, Kenneth
AU - Watkins, Bradley
AU - Johnson, Tamara
AU - Rodriguez, Joy Anne
AU - Barton, Mary B.
T1 - Screening for Chronic Obstructive Pulmonary Disease Using Spirometry: Summary of the Evidence for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/04//4/1/2008
VL - 148
IS - 7
M3 - Article
SP - 535
EP - 549
SN - 00034819
AB - Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Fewer than half of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and diagnosis often occurs in advanced stages of the disease. Purpose: To summarize the evidence on screening for COPD using spirometry for the U.S. Preventive Services Task Force (USPSTF). Data Sources: English-language articles identified in PubMed and the Cochrane Library through January 2007, recent systematic reviews, expert suggestions, and reference lists of retrieved articles. Study Selection: Explicit inclusion and exclusion criteria were used for each of the 8 key questions on benefits and harms of screening. Eligible study types varied by question. Data Extraction: Studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: Pharmacologic treatments for COPD reduce acute exacerbations in patients with severe disease. However, severe COPD is uncommon in the general U.S. population. Spirometry has not been shown to independently increase smoking cessation rates. Potential harms from screening include false-positive results and adverse effects from subsequent unnecessary therapy. Data on the prevalence of airflow obstruction in the U.S. population were used to calculate projected outcomes from screening groups defined by age and smoking status. Limitation: No studies provide direct evidence on health outcomes associated with screening for COPD. Conclusion: Screening for COPD using spirometry is likely to identify a predominance of patients with mild to moderate airflow obstruction who would not experience additional health benefits if labeled as having COPD. Hundreds of patients would need to undergo spirometry to defer a single exacerbation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases -- Diagnosis
KW - SPIROMETRY
KW - RESPIRATORY obstructions
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 31637776; Lin, Kenneth 1; Email Address: kenneth.lin@ahrq.hhs.gov Watkins, Bradley 2 Johnson, Tamara 3 Rodriguez, Joy Anne 4 Barton, Mary B. 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Veterans Affairs Medical Center, 50 Irving St NW, Washington, DC 20422 3: University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201 4: Brooks Air Force Base, Brooks City-Base, TX 78235; Source Info: 4/1/2008, Vol. 148 Issue 7, p535; Subject Term: OBSTRUCTIVE lung diseases -- Diagnosis; Subject Term: SPIROMETRY; Subject Term: RESPIRATORY obstructions; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 15p; Illustrations: 4 Diagrams, 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105915504
T1 - Screening for chronic obstructive pulmonary disease using spirometry: summary of the evidence for the U.S. Preventive Services Task Force.
AU - Lin K
AU - Watkins B
AU - Johnson T
AU - Rodriguez JA
AU - Barton MB
Y1 - 2008/04//4/1/2008
N1 - Accession Number: 105915504. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20080516. Revision Date: 20150711. Publication Type: Journal Article; CEU; consumer/patient teaching materials; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Pulmonary Disease, Chronic Obstructive -- Diagnosis
KW - Spirometry
KW - Education, Continuing (Credit)
KW - Medical Practice, Evidence-Based
KW - Patient Education
KW - United States Preventive Services Task Force
SP - 535
EP - 543
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 148
IS - 7
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. Fewer than half of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and diagnosis often occurs in advanced stages of the disease. PURPOSE: To summarize the evidence on screening for COPD using spirometry for the U.S. Preventive Services Task Force (USPSTF). DATA SOURCES: English-language articles identified in PubMed and the Cochrane Library through January 2007, recent systematic reviews, expert suggestions, and reference lists of retrieved articles. STUDY SELECTION: Explicit inclusion and exclusion criteria were used for each of the 8 key questions on benefits and harms of screening. Eligible study types varied by question. DATA EXTRACTION: Studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. DATA SYNTHESIS: Pharmacologic treatments for COPD reduce acute exacerbations in patients with severe disease. However, severe COPD is uncommon in the general U.S. population. Spirometry has not been shown to independently increase smoking cessation rates. Potential harms from screening include false-positive results and adverse effects from subsequent unnecessary therapy. Data on the prevalence of airflow obstruction in the U.S. population were used to calculate projected outcomes from screening groups defined by age and smoking status. LIMITATION: No studies provide direct evidence on health outcomes associated with screening for COPD. CONCLUSION: Screening for COPD using spirometry is likely to identify a predominance of patients with mild to moderate airflow obstruction who would not experience additional health benefits if labeled as having COPD. Hundreds of patients would need to undergo spirometry to defer a single exacerbation.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. kenneth.lin@ahrq.hhs.gov
U2 - PMID: 18316746.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105748220
T1 - Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study.
AU - Hines CJ
AU - Deddens JA
AU - Jaycox LB
AU - Andrews RN
AU - Striley CA
AU - Alavanja MC
Y1 - 2008/04//
N1 - Accession Number: 105748220. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Agriculture
KW - Indoles -- Administration and Dosage
KW - Occupational Exposure -- Analysis
KW - Pesticides -- Administration and Dosage
KW - Algorithms
KW - Environmental Monitoring -- Methods
KW - Female
KW - Fruit
KW - Indoles -- Analysis
KW - Male
KW - Models, Biological
KW - Pesticides -- Analysis
KW - Human
SP - 153
EP - 166
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 3
PB - Oxford University Press / USA
SN - 0003-4878
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-14, Cincinnati, OH 45226, USA. chines@cde.gov
U2 - PMID: 18326518.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Roberts, Rosemary
AU - Styrt, Barbara
AU - McCune, Susan
T1 - FDA perspective on antivirals against biothreats: Communicate early and often
JO - Antiviral Research
JF - Antiviral Research
Y1 - 2008/04//
VL - 78
IS - 1
M3 - Article
SP - 60
EP - 63
SN - 01663542
AB - Abstract: Development of antiviral products for certain highly pathogenic viruses with limited available treatments, such as viruses that may have biothreat potential, is critically important and challenging. The mission of the FDA is to protect the public health by assuring the safety, efficacy and quality of such products. Human clinical trials are critically important whenever relevant naturally occurring diseases can appropriately be studied. In selected situations when clinical studies are not ethical and field efficacy studies are not feasible, the Animal Rule (67 FR 37988, 2002) introduces the possibility of drug/biologic approval/licensure based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. This approach necessitates the development of well-delineated animal models predictive of human disease and treatment responses, and plans for adding human information if suitable circumstances arise. Efficient development of therapeutics against these agents requires collaborative efforts among industry, academia and federal agencies. [Copyright &y& Elsevier]
AB - Copyright of Antiviral Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - VIRUSES
KW - CLINICAL trials
KW - Animal Rule
KW - Antiviral products
KW - Biothreats
KW - Clinical trials
KW - Drug development
KW - Drugs
KW - Food and Drug Administration (FDA)
KW - Highly pathogenic viruses
KW - Therapeutic biologics
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31399233; Roberts, Rosemary; Email Address: rosemary.roberts@fda.hhs.gov Styrt, Barbara 1 McCune, Susan 1; Affiliation: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Counter-Terrorism and Emergency Coordination, 10903 New Hampshire Avenue, White Oak Campus, Silver Spring, MD 20993, United States; Source Info: Apr2008, Vol. 78 Issue 1, p60; Subject Term: ANTIVIRAL agents; Subject Term: VIRUSES; Subject Term: CLINICAL trials; Author-Supplied Keyword: Animal Rule; Author-Supplied Keyword: Antiviral products; Author-Supplied Keyword: Biothreats; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Drug development; Author-Supplied Keyword: Drugs; Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: Highly pathogenic viruses; Author-Supplied Keyword: Therapeutic biologics; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.antiviral.2007.10.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105764029
T1 - Evaluation of gatekeeper training for suicide prevention in veterans.
AU - Matthieu MM
AU - Cross W
AU - Batres AR
AU - Flora CM
AU - Knox KL
AU - Matthieu, Monica M
AU - Cross, Wendi
AU - Batres, Alfonso R
AU - Flora, Charles M
AU - Knox, Kerry L
Y1 - 2008/04//
N1 - Accession Number: 105764029. Language: English. Entry Date: 20080711. Revision Date: 20170228. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: T32 MH020061/MH/NIMH NIH HHS/United States. NLM UID: 9504451.
KW - Clinical Competence
KW - Gatekeeping
KW - Physicians, Family -- Education
KW - Suicide -- Prevention and Control
KW - Suicide -- Psychosocial Factors
KW - Veterans -- Psychosocial Factors
KW - Veterans -- Statistics and Numerical Data
KW - Adult
KW - Mental Health Services -- Utilization
KW - Middle Age
KW - Preventive Health Care -- Utilization
KW - Human
SP - 148
EP - 154
JO - Archives of Suicide Research
JF - Archives of Suicide Research
JA - ARCH SUICIDE RES
VL - 12
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Clinical providers and "front line" nonclinical staff who work with veterans, families, and communities are natural gatekeepers to identify and to refer veterans at risk for suicide. A national cohort (n = 602) of community based counseling center staff from the U.S. Department of Veterans Affairs (VA) participated in an evaluation of a brief standardized gatekeeper training program and a scripted behavioral rehearsal practice session. A significant difference in knowledge and self efficacy was observed from pre to post (p < .0001) with the nonclinicians showing larger effect sizes for knowledge (0.96 vs. 0.42) and self efficacy (0.89 vs. 0.41). Gatekeeper training for suicide prevention shows promise for increasing the capacity of VA staff to work with at risk veterans.
SN - 1381-1118
AD - Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO 63130, USA
AD - Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO.
U2 - PMID: 18340597.
DO - 10.1080/13811110701857491
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Littleton, Judith
AU - Park, Julie
AU - Thornley, Craig
AU - Anderson, Anneka
AU - Lawrence, Jody
T1 - Migrants and tuberculosis: analysing epidemiological data with ethnography.
JO - Australian & New Zealand Journal of Public Health
JF - Australian & New Zealand Journal of Public Health
Y1 - 2008/04//
VL - 32
IS - 2
M3 - Article
SP - 142
EP - 149
SN - 13260200
AB - Objective: Media portrayals of tuberculosis (TB) in New Zealand are of immigrants who enter the country with active disease and pose a threat to inhabitants, which fosters a popular perception that border control is the best and only response to disease control. This paper reviews both New Zealand and international data on TB rates, causes and transmission among migrant populations to elucidate the precise nature of the link between immigration and TB rates. Methods: Recent information from scholarly journals on immigration and TB was reviewed. Surveillance data from New Zealand and comparable information from other low-incidence countries were reviewed. Conclusions and Implications: The importation of active TB is only a minor part of the total TB burden. While effective border control is essential, equally, if not more important, are the circumstances that promote the reactivation of latent TB infection in migrant communities, including migrants’ experiences in transit and after arrival, structural conditions, and personal characteristics. For sound prevention strategies, attention needs to be paid to the existence of transnational communities and the conditions for migrants, rather than placing a singular focus on place of birth. [ABSTRACT FROM AUTHOR]
AB - Copyright of Australian & New Zealand Journal of Public Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMIGRATION & immigration
KW - TUBERCULOSIS
KW - MYCOBACTERIAL diseases
KW - LUNG diseases
KW - IMMIGRANTS
KW - PREVENTIVE medicine
KW - ETHNOLOGY
KW - EPIDEMIOLOGY
KW - NEW Zealand
KW - Medical anthropology
KW - migrant health
KW - New Zealand
KW - transnationalism
N1 - Accession Number: 31625114; Littleton, Judith 1; Email Address: j.littleton@auckland.ac.nz; Park, Julie 1; Thornley, Craig 2; Anderson, Anneka 1; Lawrence, Jody 3; Affiliations: 1: Anthropology Department, University of Auckland, New Zealand; 2: Auckland Regional Public Health Service, New Zealand; 3: School of Geography and Environmental Sciences, University of Auckland, New Zealand; Issue Info: Apr2008, Vol. 32 Issue 2, p142; Thesaurus Term: EMIGRATION & immigration; Subject Term: TUBERCULOSIS; Subject Term: MYCOBACTERIAL diseases; Subject Term: LUNG diseases; Subject Term: IMMIGRANTS; Subject Term: PREVENTIVE medicine; Subject Term: ETHNOLOGY; Subject Term: EPIDEMIOLOGY; Subject: NEW Zealand; Author-Supplied Keyword: Medical anthropology; Author-Supplied Keyword: migrant health; Author-Supplied Keyword: New Zealand; Author-Supplied Keyword: transnationalism; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1753-6405.2008.00191.x
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DP - EBSCOhost
DB - buh
ER -
TY - ABST
AU - Heaton, H. Thompson
AU - Thomadsen, Bruce R.
AU - Jani, Shirish K.
AU - Masten, Jeffery P.
AU - Napolitano, Mary E.
AU - Ouhib, Zoubir
AU - Reft, Chester S.
AU - Rivard, Mark J.
AU - Subramanian, Manny
AU - Suleiman, Orhan H.
T1 - Using a medical product: Follow the label or not (case studies in brachytherapy)
JO - Brachytherapy
JF - Brachytherapy
Y1 - 2008/04//
VL - 7
IS - 2
M3 - Abstract
SP - 172
EP - 172
SN - 15384721
N1 - Accession Number: 31679099; Heaton, H. Thompson 1 Thomadsen, Bruce R. 2 Jani, Shirish K. 3 Masten, Jeffery P. 4 Napolitano, Mary E. 5 Ouhib, Zoubir 6 Reft, Chester S. 7 Rivard, Mark J. 8 Subramanian, Manny 9 Suleiman, Orhan H. 10; Affiliation: 1: Consultant, Hagerstown, MD 2: Human Oncology & Medical Physics, University of Wisconsin, Madison, WI 3: Radiation Oncology, Sharp Memorial Hospital, San Diego, CA 4: Radiation Oncology, Medical X-ray Center, Sioux Falls, MN 5: Research and Development, Elekta, Inc., Norcross, GA 6: Radiation Oncology, Lynn Regional Cancer Center, Delray Beach, FL 7: Radiation Oncology, University of Chicago, Chicago, IL 8: Radiation Oncology, Tufts University, Boston, MA 9: Research and Development, Best Medical International, Inc., Springfield, VA 10: Center for Drug Evaluation & Research, Food and Drug Administration, Silver Spring, MD; Source Info: Apr2008, Vol. 7 Issue 2, p172; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.brachy.2008.02.249
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31679099&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105748348
T1 - Transparency, job satisfaction among topics at Leape roundtables.
AU - Clancy C
Y1 - 2008/04//2008 Apr
N1 - Accession Number: 105748348. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; USA. Special Interest: Patient Safety; Quality Assurance.
KW - Job Satisfaction
KW - Patient Safety
KW - Quality Improvement
KW - Risk Management
SP - 1
EP - 2
JO - Briefings on Patient Safety
JF - Briefings on Patient Safety
JA - BRIEF PATIENT SAF
VL - 9
IS - 4
CY - Danvers, Massachusetts
PB - HCPro
SN - 1528-7637
AD - Director, Agency for Healthcare Research and Quality (AHRQ)
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tesfamariam, Belay
T1 - Platelet function in intravascular device implant-induced intimal injury
JO - Cardiovascular Revascularization Medicine
JF - Cardiovascular Revascularization Medicine
Y1 - 2008/04//
VL - 9
IS - 2
M3 - Article
SP - 78
EP - 87
SN - 15538389
AB - Abstract: Platelets are involved in the rapid response to intimal injury in which the underlying thrombogenic subendothelial matrix is exposed, leading to platelet adhesion, secretion, aggregation, and initiation of arterial thrombus formation. The platelet activation pathway involves a multistep process of distinct receptors, adhesive ligands, release of mediators, receptor–ligand interactions, and recruitment of more platelets to the site of injury. The balance between blood fluidity and intimal injury-induced arterial thrombosis is maintained by an intact endothelium that controls vessel tone, synthesizes inhibitors and activators of platelet function, and thereby allows the free flow of blood cell elements. An intravascular device implant causes intimal injury, which is accompanied by decreased antithrombotic potential of the endothelial cells and increased release of prothrombotic substances. A trigger for the formation of intimal injury-induced thrombus formation may be due to endothelial dysfunction and/or the loss of endothelial cell barrier between the subendothelial matrix and flowing blood, which allows initiation of platelet activation. A thorough understanding of the platelet regulatory mechanisms is necessary to develop effective antiplatelet therapy to prevent the complications of thrombosis following revascularization procedures using percutaneous coronary intervention. This review summarizes the temporal events following intravascular device implants, including endothelial cell injury, platelet activation, receptor-mediated signaling events, platelet-rich thrombus formation, and the redundant platelet pathways, all of which may be potential therapeutic targets. [Copyright &y& Elsevier]
AB - Copyright of Cardiovascular Revascularization Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD platelets
KW - INTRAVASCULAR ultrasonography
KW - PROTHROMBIN
KW - WOUNDS & injuries
KW - Antiplatelet targets
KW - Endothelial injury
KW - Platelet mediators
KW - Signaling pathways
KW - Stent device
KW - Thrombosis
N1 - Accession Number: 32077806; Tesfamariam, Belay 1; Email Address: belay.tesfamariam@fda.hhs.gov; Affiliation: 1: Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA; Source Info: Apr2008, Vol. 9 Issue 2, p78; Subject Term: BLOOD platelets; Subject Term: INTRAVASCULAR ultrasonography; Subject Term: PROTHROMBIN; Subject Term: WOUNDS & injuries; Author-Supplied Keyword: Antiplatelet targets; Author-Supplied Keyword: Endothelial injury; Author-Supplied Keyword: Platelet mediators; Author-Supplied Keyword: Signaling pathways; Author-Supplied Keyword: Stent device; Author-Supplied Keyword: Thrombosis; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.carrev.2007.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105647971
T1 - Platelet function in intravascular device implant-induced intimal injury.
AU - Tesfamariam B
Y1 - 2008/04//
N1 - Accession Number: 105647971. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101238551.
KW - Blood Platelets -- Physiology
KW - Blood Vessel Prosthesis -- Adverse Effects
KW - Blood Vessels -- Injuries
KW - Platelet Activation -- Physiology
KW - Animals
KW - Platelet Aggregation Inhibitors -- Pharmacodynamics
KW - Platelet Function Tests
KW - Signal Transduction
KW - Thrombosis -- Etiology
KW - Thrombosis -- Physiopathology
SP - 78
EP - 87
JO - Cardiovascular Revascularization Medicine
JF - Cardiovascular Revascularization Medicine
JA - CARDIOVASC REVASC MED
VL - 9
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1553-8389
AD - Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.
U2 - PMID: 18486081.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cook, Judith A.
AU - Blyler, Crystal R.
AU - Burke-Miller, Jane K.
AU - McFarlane, William R.
AU - Leff, H. Stephen
AU - Mueser, Kim T.
AU - Gold, Paul B.
AU - Goldberg, Richard W.
AU - Shafer, Michael S.
AU - Onken, Steven J.
AU - Donegan, Kate
AU - Carey, Martha Ann
AU - Razzano, Lisa A.
AU - Grey, Dennis D.
AU - Pickett-Schenk, Susan A.
AU - Kaufmann, Caroline
T1 - Effectiveness of Supported Employment for Individuals with Schizophrenia: Results of a Multi-Site, Randomized Trial.
JO - Clinical Schizophrenia & Related Psychoses
JF - Clinical Schizophrenia & Related Psychoses
Y1 - 2008/04//
VL - 2
IS - 1
M3 - Article
SP - 37
EP - 46
SN - 19351232
AB - Background: Prior studies of supported employment efficacy for individuals with schizophrenia have yielded mixed results, with some finding poorer outcomes for those with this diagnosis and others finding no differences.Aims: This multi-site effectiveness trial examined the relative impact of diagnosis with schizophrenia and evidence-based practice supported employment on the likelihood of competitive employment.Method: At seven U.S. sites, 1,273 outpatients with severe mental illness were randomly assigned to either an experimental supported employment program or to a comparison/services as usual condition and followed for two years. Data collection involved semi-annual, in-person interviews, and weekly recording of all paid employment by vocational and research staff. Mixed-effects random regression analysis was used to examine the effects of study condition, schizophrenia diagnosis, and their interaction, on the likelihood of competitive employment.Results: Subjects in experimental group programs and those with diagnoses other than schizophrenia (predominantly bipolar disorder and major depression) were significantly more likely to be competitively employed than those in control programs and those with diagnoses of schizophrenia. However, an interaction effect between study condition and diagnosis was observed in which experimental group treatment ameliorated the negative effects of diagnosis on employment outcome.Discussion: Evidence-based supported employment interventions are superior to services as usual/comparison programs in assisting individuals with schizophrenia to attain competitive employment. Given recent evidence of this model's effectiveness outside the U.S. and interest in its promotion internationally, it has global potential to further the recovery potential of individuals with psychiatric disabilities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Schizophrenia & Related Psychoses is the property of Walsh Medical Media, LLC. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEOPLE with disabilities -- Employment
KW - MENTAL depression
KW - MENTAL health
KW - SCHIZOPHRENIA
KW - SCHIZOPHRENICS
KW - MENTAL illness
KW - SCHIZOAFFECTIVE disorders
KW - PERSONALITY disorders
KW - PERSONNEL management
KW - Competitive Employment
KW - Multi-Site Trial
KW - Randomized Trial
KW - Schizophrenia
KW - Supported Employment
N1 - Accession Number: 31546795; Cook, Judith A. 1; Email Address: cook@ripco.com Blyler, Crystal R. 2 Burke-Miller, Jane K. 1 McFarlane, William R. 3 Leff, H. Stephen 4 Mueser, Kim T. 5 Gold, Paul B. 6 Goldberg, Richard W. 7 Shafer, Michael S. 8 Onken, Steven J. 9 Donegan, Kate 10 Carey, Martha Ann 11 Razzano, Lisa A. 1 Grey, Dennis D. 1 Pickett-Schenk, Susan A. 1 Kaufmann, Caroline; Affiliation: 1: Department of Psychiatry, University of Illinois at Chicago 2: Center for Mental Health Services, Rockville, MD 3: Maine Medical Center, Portland, ME 4: Human Services Research Institute and Harvard Medical School Dept. of Psychiatry at Cambridge Health Alliance, Cambridge, MA 5: Dartmouth University, Concord, NH 6: Medical University of South Carolina, Charleston, SC 7: Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 8: Arizona State University, Phoenix, AZ 9: University of Hawaii, Honolulu, HI 10: Behavioral Health Consultant, Philadelphia, PA 11: Azusa Pacific University, Azusa, CA; Source Info: Apr2008, Vol. 2 Issue 1, p37; Subject Term: PEOPLE with disabilities -- Employment; Subject Term: MENTAL depression; Subject Term: MENTAL health; Subject Term: SCHIZOPHRENIA; Subject Term: SCHIZOPHRENICS; Subject Term: MENTAL illness; Subject Term: SCHIZOAFFECTIVE disorders; Subject Term: PERSONALITY disorders; Subject Term: PERSONNEL management; Author-Supplied Keyword: Competitive Employment; Author-Supplied Keyword: Multi-Site Trial; Author-Supplied Keyword: Randomized Trial; Author-Supplied Keyword: Schizophrenia; Author-Supplied Keyword: Supported Employment; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; Number of Pages: 10p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaput, Jim
T1 - Nutrigenomics research for personalized nutrition and medicine
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
Y1 - 2008/04//
VL - 19
IS - 2
M3 - Article
SP - 110
EP - 120
SN - 09581669
AB - Current nutritional and genetic epidemiological methods yield ‘risk factors’ on the basis of population studies. Risk factors, however, are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. These measures are often assumed to apply to individuals who are likely to differ in genetic make-up, lifestyle, and dietary patterns than to the individuals in the study population. Developing individual risk factors in light of the genetic diversity of human populations, the complexity of foods, culture and lifestyle, and the variety of metabolic processes that lead to health or disease is a significant challenge for personalizing dietary advice for healthy or individuals with chronic disease. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Biotechnology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - NUTRITION
KW - GENETICS
KW - DISEASES -- Risk factors
KW - LIFESTYLES
KW - DIET
KW - CHRONIC diseases
N1 - Accession Number: 31923319; Kaput, Jim 1; Email Address: James.Kaput@fda.hhs.gov; Affiliation: 1: Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States; Source Info: Apr2008, Vol. 19 Issue 2, p110; Subject Term: EPIDEMIOLOGY; Subject Term: NUTRITION; Subject Term: GENETICS; Subject Term: DISEASES -- Risk factors; Subject Term: LIFESTYLES; Subject Term: DIET; Subject Term: CHRONIC diseases; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.copbio.2008.02.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neznanov, Nickolay
AU - Kondratova, Anna
AU - Chumakov, Konstantin M.
AU - Neznanova, Lubov
AU - Kondratov, Roman
AU - Banerjee, Amiya K.
AU - Gudkov, Andrei V.
T1 - Quercetinase Pirin Makes Poliovirus Replication Resistant to Flavonoid Quercetin.
JO - DNA & Cell Biology
JF - DNA & Cell Biology
Y1 - 2008/04//
VL - 27
IS - 4
M3 - Article
SP - 191
EP - 198
PB - Mary Ann Liebert, Inc.
SN - 10445498
AB - Flavonoid quercetin and its derivative, methylquercetin, inhibit the replication of poliovirus in several cell lines. Here, we show that replication of poliovirus is inhibited by quercetin and that the extent of this inhibition depends on the intracellular content of pirin, a quercetinase. HeLa cells contain higher content of pirin protein than normal kidney human epithelial (NKE) or 293 cells do. Poliovirus replication in HeLa cells is significantly more resistant to quercetin than its replication in NKE and 293 cells. Overexpression of pirin reduced antiviral inhibitory effect of quercetin, while siRNA-induced suppression of pirin level made poliovirus replication more sensitive to the flavonoid. The results suggest that quercetinase activity of pirin determines the resistance of poliovirus infection to quercetin. [ABSTRACT FROM AUTHOR]
AB - Copyright of DNA & Cell Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVONOIDS
KW - QUERCETIN
KW - POLIOVIRUS
KW - HELA cells
KW - CELL culture
N1 - Accession Number: 31636063; Neznanov, Nickolay 1 Kondratova, Anna 1 Chumakov, Konstantin M. 2 Neznanova, Lubov 1; Email Address: neznann@ccf.org Kondratov, Roman 3 Banerjee, Amiya K. 1 Gudkov, Andrei V. 4,5; Affiliation: 1: Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 3: Department of Biology, Geology, and Environmental Science, Cleveland State University, Cleveland, Ohio 4: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 5: Cleveland Biolabs, Buffalo, New York; Source Info: Apr2008, Vol. 27 Issue 4, p191; Subject Term: FLAVONOIDS; Subject Term: QUERCETIN; Subject Term: POLIOVIRUS; Subject Term: HELA cells; Subject Term: CELL culture; Number of Pages: 8p; Illustrations: 9 Black and White Photographs, 3 Graphs; Document Type: Article
L3 - 10.1089/dna.2007.0682
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jetley, Raoul
AU - Anderson, Paul
T1 - Using static analysis to evaluate software in medical devices.
JO - Embedded Systems Design
JF - Embedded Systems Design
Y1 - 2008/04//
VL - 21
IS - 4
M3 - Article
SP - 40
EP - 44
SN - 15582493
AB - The article focuses on static analysis tools, used to detect potential flaws in modern medical-device software. The tools are being utilized by the researchers at the FDA's Office of Science and Engineering Laboratories probing new techniques, for analyzing software to reduce public health threat. It is said that an advanced static analysis tool operates by performing an abstract or symbolic execution of the program.
KW - MEDICAL equipment
KW - MEDICAL research
KW - LABORATORIES
KW - SURVEILLANCE detection
KW - PUBLIC health
KW - SOFTWARE
N1 - Accession Number: 31709983; Jetley, Raoul 1; Email Address: raoul.jetley@fda.hhs.gov Anderson, Paul 2; Email Address: paul@grammatech.com; Affiliation: 1: US FDA, Center for Devices and Radiological Health/Office of Science and Engineering Laboratories 2: GrammaTech; Source Info: Apr2008, Vol. 21 Issue 4, p40; Subject Term: MEDICAL equipment; Subject Term: MEDICAL research; Subject Term: LABORATORIES; Subject Term: SURVEILLANCE detection; Subject Term: PUBLIC health; Subject Term: SOFTWARE; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105498686
T1 - Incidence and completeness of notification of Legionnaires' disease in The Netherlands: covariate capture-recapture analysis acknowledging regional differences.
AU - Van Hest NA
AU - Hoebe CJ
AU - Den Boer JW
AU - Vermunt JK
AU - Ijzerman EP
AU - Boersma WG
AU - Richardus JH
Y1 - 2008/04//
N1 - Accession Number: 105498686. Language: English. Entry Date: 20090417. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Disease Surveillance
KW - Legionnaires' Disease -- Epidemiology
KW - Legionnaires' Disease -- Prevention and Control
KW - Outcome Assessment
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Child
KW - Child, Preschool
KW - Data Collection
KW - Diagnosis-Related Groups -- Statistics and Numerical Data
KW - Female
KW - Geographic Factors
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Legionnaires' Disease -- Etiology
KW - Male
KW - Middle Age
KW - Models, Statistical
KW - Netherlands
KW - Patient Admission
KW - Human
SP - 540
EP - 550
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 136
IS - 4
PB - Cambridge University Press
AB - To estimate incidence and completeness of notification of Legionnaires' disease (LD) in The Netherlands in 2000 and 2001, we performed a capture-recapture analysis using three registers: Notifications, Laboratory results and Hospital admissions. After record-linkage, 373 of the 780 LD patients identified were notified. Ascertained under-notification was 52.2%. Because of expected and observed regional differences in the incidence rate of LD, alternatively to conventional log-linear capture-recapture models, a covariate (region) capture-recapture model, not previously used for estimating infectious disease incidence, was specified and estimated 886 LD patients (95% confidence interval 827-1022). Estimated under-notification was 57.9%. Notified, ascertained and estimated average annual incidence rates of LD were 1.15, 2.42 and 2.77/100 000 inhabitants respectively, with the highest incidence in the southern region of The Netherlands. Covariate capture-recapture analysis acknowledging regional differences of LD incidence appears to reduce bias in the estimated national incidence rate.
SN - 0950-2688
AD - Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands. vanhestr@ggd.rotterdam.nl
U2 - PMID: 17588278.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wang, Shiow Y.
AU - Bowman, Linda
AU - Ding, Min
T1 - Methyl jasmonate enhances antioxidant activity and flavonoid content in blackberries (Rubus sp.) and promotes antiproliferation of human cancer cells
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008/04//
VL - 107
IS - 3
M3 - Article
SP - 1261
EP - 1269
SN - 03088146
AB - Abstract: The effects of preharvest methyl jasmonate (MJ) application on fruit quality, antioxidant activity and flavonoid content in blackberries (Rubus sp.) were determined. Anticancer activity against human lung A549 cells and HL-60 leukemia cells was also evaluated. Three blackberry cultivars (Chester Thornless, Hull Thornless and Triple Crown) were used in these experiments. Blackberries treated with MJ (0.01 and 0.1mM) had higher soluble solids content, and lower titratable acids than untreated fruit as well as enhanced content of flavonoids and increased antioxidant capacity. Extracts of treated fruit showed enhanced inhibition of A549 cell and HL-60 cell proliferation and induced the apoptosis of HL-60 cells. Cultivar Hull Thornless had higher soluble solids and lower titratable acids compared to cv. Chester Thornless and Triple Crown. On the basis of fresh weight of fruit, Hull Thornless also had significantly higher anthocyanin, total phenolic content, antioxidant and antiproliferation activity than other two cultivars. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - REPRODUCTION
KW - CELL division (Biology)
KW - CELLULAR growth
KW - Antioxidant activity
KW - Antiproliferation
KW - Blackberries
KW - Methyl jasmonate
KW - Rubus sp.
N1 - Accession Number: 27742864; Wang, Shiow Y. 1; Email Address: shiow.wang@ars.usda.gov Bowman, Linda 2 Ding, Min 2; Affiliation: 1: Genetic Improvement of Fruit and Vegetable Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705-2350, United States 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States; Source Info: Apr2008, Vol. 107 Issue 3, p1261; Subject Term: CELLS; Subject Term: REPRODUCTION; Subject Term: CELL division (Biology); Subject Term: CELLULAR growth; Author-Supplied Keyword: Antioxidant activity; Author-Supplied Keyword: Antiproliferation; Author-Supplied Keyword: Blackberries; Author-Supplied Keyword: Methyl jasmonate; Author-Supplied Keyword: Rubus sp.; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.foodchem.2007.09.065
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Sung-Hye
AU - Lee, Chang-Hee
AU - Jang, Mi-Ran
AU - Son, Young-Wook
AU - Lee, Sang-Mok
AU - Choi, In-Sun
AU - Kim, So-Hee
AU - Kim, Dai-Byung
T1 - Aflatoxins contamination in spices and processed spice products commercialized in Korea
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008/04//
VL - 107
IS - 3
M3 - Article
SP - 1283
EP - 1288
SN - 03088146
AB - Abstract: A survey for total aflatoxins (aflatoxins B1, B2, G1, and G2) was conducted on 88 spices and processed spice products commercialized in Korea. The presence of aflatoxins was determined by high-performance liquid chromatography (HPLC) with fluorescence detector using immunoaffinity column clean-up. Total aflatoxins (AFs) are detected in 12 samples (13.6% of incidence) including seven red pepper powder, two red pepper pastes (Kochujang), two curry and one ginger product. The contamination levels are 0.08–4.45μg/kg as aflatoxin B1 and 0.08–4.66μg/kg as AFs. The liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis on contaminated samples was conducted for the confirmation of detected aflatoxins. The 12 samples which showed aflatoxins by HPLC/FLD were confirmed as aflatoxins by LC–MS/MS. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFLATOXINS
KW - CHROMATOGRAPHIC analysis
KW - HIGH performance liquid chromatography
KW - ENGINEERING instruments
KW - Aflatoxins
KW - HPLC–FLD
KW - Immunoaffinity column
KW - LC–MS/MS
KW - Spices
N1 - Accession Number: 27742869; Cho, Sung-Hye 1 Lee, Chang-Hee; Email Address: chang65@hanmail.net Jang, Mi-Ran 1 Son, Young-Wook 1 Lee, Sang-Mok 1 Choi, In-Sun 1 Kim, So-Hee 1 Kim, Dai-Byung 1; Affiliation: 1: Busan Regional Agency, Korea Food and Drug Administration, Busan 608-829, Republic of Korea; Source Info: Apr2008, Vol. 107 Issue 3, p1283; Subject Term: AFLATOXINS; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: HIGH performance liquid chromatography; Subject Term: ENGINEERING instruments; Author-Supplied Keyword: Aflatoxins; Author-Supplied Keyword: HPLC–FLD; Author-Supplied Keyword: Immunoaffinity column; Author-Supplied Keyword: LC–MS/MS; Author-Supplied Keyword: Spices; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.foodchem.2007.08.049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zinn, Jacqueline S.
AU - Spector, William D.
AU - Weimer, David L.
AU - Mukamel, Dana B.
T1 - Strategic Orientation and Nursing Home Response to Public Reporting of Quality Measures: An Application of the Miles and Snow Typology.
JO - Health Services Research
JF - Health Services Research
Y1 - 2008/04//
VL - 43
IS - 2
M3 - Article
SP - 598
EP - 615
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To assess whether differences in strategic orientation of nursing homes as identified by the Miles and Snow typology are associated with differences in their response to the publication of quality measures on the Nursing Home Compare website. Data Sources. Administrator survey of a national 10 percent random sample (1,502 nursing homes) of all facilities included in the first publication of the Nursing Home Compare report conducted in May–June 2004; 724 responded, yielding a response rate of 48.2 percent. Study Design. The dependent variables are dichotomous, indicating whether or not action was taken and the type of action taken. Four indicator variables were created for each of the four strategic types: Defender, Analyzer, Prospector, and Reactor. Other variables were included in the seven logistic regression models to control for factors other than strategic type that could influence nursing home response to public disclosure of their quality of care. Data Collection/Extraction Methods. Survey data were merged with data on quality measures and organizational characteristics from the first report (November 2002). Principal Findings. About 43 percent of surveyed administrators self-typed as Defenders, followed by Analyzers (33 percent), and Prospectors (19 percent). The least self-selected strategic type was the Reactor (6.6 percent). In general, results of the regression models indicate differences in response to quality measure publication by strategic type, with Prospectors and Analyzers more likely, and Reactors less likely, to respond than Defenders. Conclusions. While almost a third of administrators took no action at all, our results indicate that whether, when, and how nursing homes reacted to publication of federally reported quality measures is associated with strategic orientation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities
KW - MEDICAL care surveys
KW - COMPARATIVE studies
KW - LOGISTIC regression analysis
KW - HEALTH facilities
KW - Nursing homes
KW - quality measures
KW - strategy
N1 - Accession Number: 31424855; Zinn, Jacqueline S. 1 Spector, William D. 2 Weimer, David L. 3 Mukamel, Dana B. 4; Affiliation: 1: Professor, Department of Risk, Insurance and Healthcare Management, Temple University, 413 Ritter Annex, Philadelphia, PA 19122. 2: Senior Social Scientist, Center for Delivery, Organizations and Markets, Agency for Healthcare Research and Quality, Rockville, MD. 3: Professor of Political Science and Public Affairs, RobertM. La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI. 4: Professor, Department of Medicine, Senior Fellow, Center for Health Policy Research, University of California, Irvine, CA.; Source Info: Apr2008, Vol. 43 Issue 2, p598; Subject Term: NURSING care facilities; Subject Term: MEDICAL care surveys; Subject Term: COMPARATIVE studies; Subject Term: LOGISTIC regression analysis; Subject Term: HEALTH facilities; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: quality measures; Author-Supplied Keyword: strategy; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 18p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2007.00781.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chander, G.
AU - Josephs, J.
AU - Fleishman, J. A.
AU - Korthuis, P. T.
AU - Gaist, P.
AU - Hellinger, J.
AU - Gebo, K.
T1 - Alcohol use among HIV-infected persons in care: results of a multi-site survey.
JO - HIV Medicine
JF - HIV Medicine
Y1 - 2008/04//
VL - 9
IS - 4
M3 - Article
SP - 196
EP - 202
PB - Wiley-Blackwell
SN - 14642662
AB - Objective We sought to determine the prevalence of any alcohol use and hazardous alcohol consumption among HIV-infected individuals engaged in care and to identify factors associated with hazardous alcohol use. Methods During 2003, 951 patients were interviewed at 14 HIV primary care sites in the USA. Hazardous drinking was defined as >14 drinks/week or ≥5 drinks/occasion for men and >7 drinks/week or ≥4 drinks/occasion for women. Moderate alcohol use was consumption at less than hazardous levels. We used logistic regression to identify factors associated with any alcohol use and hazardous alcohol use. Results Forty per cent of the sample reported any alcohol use in the 4 weeks prior to the interview; 11% reported hazardous use. In multivariate regression, male sex [adjusted odds ratio (AOR) 1.52 (95% confidence interval, CI, 1.07–2.16)], a college education (compared to
PB - Springer Science & Business Media B.V.
AB - Background: The relationship between passive smoking and sleep is uncertain. Purpose: To examine the association of passive/active smoking with sleep disturbances. Method: 732 women and 1,896 men, working in a suburb of Tokyo, were surveyed using a self-administered questionnaire. Information on smoking, passive smoking exposure, and sleep was elicited. Exposure levels to passive smoking were assessed separately at work and at home as no, occasional, or regular exposure. Risk of sleep disturbances according to smoking status was estimated using logistic regression with odds ratios (OR) and 95% confidence intervals (CIs) as measures of association. Results: Compared to never smokers, odds of difficulty awakening in the morning (DAM) in current smokers were significantly higher for women (OR 1.95) and men (OR 1.50), while increased difficulty initiating sleep (OR 1.88) and decreased early morning awakening (OR 0.31) were found only in women. Never smoking men occasionally exposed to passive smoking at work but not at home had increased odds (OR 1.81) of short sleep duration (SSD, < 6 h) than unexposed counterparts. Conclusions: The analyses suggest that exposure to passive smoking at work is associated with SSD in men, while current smoking relates to various subtypes of sleep disturbances in both sexes.
SN - 1070-5503
AD - National Institute of Occupational Safety and Health, Kawasaki, Japan
U2 - PMID: 18569126.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105556233
T1 - Hardiness and psychological distress in a cohort of police officers.
AU - Andrew ME
AU - McCanlies EC
AU - Burchfiel CM
AU - Charles LE
AU - Hartley TA
AU - Fekedulegn D
AU - Violanti JM
Y1 - 2008///2008 Spring
N1 - Accession Number: 105556233. Language: English. Entry Date: 20090626. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. Special Interest: Emergency Care; Psychiatry/Psychology. Instrumentation: Impact of Events Scale (IES). NLM UID: 100888872.
KW - Depression -- Epidemiology
KW - Depression -- Psychosocial Factors
KW - Personality
KW - Police -- Statistics and Numerical Data
KW - Stress Disorders, Post-Traumatic -- Epidemiology
KW - Stress Disorders, Post-Traumatic -- Psychosocial Factors
KW - Depression -- Diagnosis
KW - Female
KW - Impact of Events Scale
KW - Male
KW - Questionnaires
KW - Stress Disorders, Post-Traumatic -- Diagnosis
KW - Human
SP - 137
EP - 147
JO - International Journal of Emergency Mental Health & Human Resilience
JF - International Journal of Emergency Mental Health & Human Resilience
JA - INT J EMERG MENT HEALTH
VL - 10
IS - 2
CY - Los Angeles, California
PB - OMICS Publishing Group
SN - 1522-4821
AD - Centers for Disease Control and Prevention, National Institute of Occupational Safety and Health, Health Effects Laboratory Division, Biostatistics and Epidemiology Branch in Morgantown, VW 26505, USA. mta6@cdc.gov
U2 - PMID: 18788348.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bryant, Laurie
AU - Burdett, Jim
AU - Del Vecchio, Paolo
AU - Epstein, Merinda
AU - Morgan, Graham
AU - O'Hagan, Mary
AU - Onken, Steve J.
AU - Swanson, Carolyn
T1 - Associated Consumer Experts (ACE).
JO - International Journal of Leadership in Public Services
JF - International Journal of Leadership in Public Services
Y1 - 2008/04//
VL - 4
IS - 1
M3 - Article
SP - 38
EP - 40
SN - 17548187
AB - The article offers information on an international mental health service user initiative called Associated Consumer Experts (ACE) that has emerged out of networks formed through the International Initiative for Mental Health Leadership (IIMHL). It states that ACE is planning to given international consultancy in recovery practice and to establish, gather, and disseminate global recovery knowledge. The IIMHL wants their consultants to have good reputation for helping to enhance services.
KW - HEALTH promotion
KW - MENTAL health services
KW - ASSOCIATIONS, institutions, etc.
KW - MEDICAL consultation
KW - MEDICAL consultants
KW - REPUTATION (Sociology)
N1 - Accession Number: 33116037; Bryant, Laurie 1 Burdett, Jim 2 Del Vecchio, Paolo 3 Epstein, Merinda 4 Morgan, Graham 5 O'Hagan, Mary Onken, Steve J. 6,7 Swanson, Carolyn 8; Affiliation: 1: Service User Consultant, National Institute for Mental Health England (NIMHE) (England) 2: Director, Mind and Body Auckland (New Zealand) 3: Associate Director for Consumer Affairs, US Center for Mental Health Services/Substance Abuse and Mental Health Services Administration (USA) 4: Director of Ourconsumerspace, Technical Advice Centre for Consumers, Melbourne (Australia) 5: Highland Users Group (Scotland) 6: School of Social Work, University of Hawaii, Manoa 7: Mental Health Services Research, Evaluation and Training and Social Science Research Institute, Honolulu (USA) 8: Service User Workforce Development, Te Pou O Whakaaro Nui, National Centre of Mental Health Research, Information and Workforce Development (New Zealand); Source Info: Apr2008, Vol. 4 Issue 1, p38; Subject Term: HEALTH promotion; Subject Term: MENTAL health services; Subject Term: ASSOCIATIONS, institutions, etc.; Subject Term: MEDICAL consultation; Subject Term: MEDICAL consultants; Subject Term: REPUTATION (Sociology); NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 541611 Administrative Management and General Management Consulting Services; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105778172
T1 - Occupational risks for idiopathic pulmonary fibrosis mortality in the United States.
AU - Pinheiro GA
AU - Antao VC
AU - Wood JM
AU - Wassell JT
Y1 - 2008/04//2008 Apr-Jun
N1 - Accession Number: 105778172. Language: English. Entry Date: 20080801. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Occupational Exposure
KW - Pulmonary Fibrosis -- Mortality -- United States
KW - Pulmonary Fibrosis -- Risk Factors
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Dust
KW - Linear Regression
KW - Male
KW - Metals
KW - Middle Age
KW - Odds Ratio
KW - Poisson Distribution
KW - United States
KW - Whites
KW - Human
SP - 117
EP - 123
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 14
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Metal and wood dust exposures have been identified as possible occupational risk factors for idiopathic pulmonary fibrosis (IPF). We analyzed mortality data using ICD-10 code J84.1--'Other interstitial pulmonary diseases with fibrosis,' derived age-adjusted mortality rates for 1999-2003, and assessed occupational risks for 1999, by calculating proportionate mortality ratios (PMRs) and mortality odds ratios (MORs) using a matched case-control approach. We identified 84,010 IPF deaths, with an age-adjusted mortality rate of 75.7 deaths/million. Mortality rates were highest among males, whites, and those aged 85 and older. Three industry categories with potential occupational exposures recognized as risk factors for IPF were identified: 'Wood buildings and mobile homes' (PMR = 4.5, 95% confidence interval (CI) 1.2-11.6 and MOR = 5.3, 95% CI 1.2-23.8), 'Metal mining' (PMR = 2.4, 95% CI 1.3-4.0 and MOR = 2.2, 95% CI 1.1-4.4), and 'Fabricated structural metal products' (PMR = 1.9, 95% CI 1.1-3.1 and MOR = 1.7, 95% CI 1.0-3.1). Workers in these industry categories may benefit from toxicological studies and improved surveillance for this disease.
SN - 1077-3525
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. germania.pinheiro@yahoo.com
U2 - PMID: 18507288.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sahakian, Nancy
AU - Kullman, Gregory
AU - Lynch, David
AU - Kreiss, Kathleen
T1 - ASTHMA ARISING IN FLAVORING-EXPOSED FOOD PRODUCTION WORKERS.
JO - International Journal of Occupational Medicine & Environmental Health
JF - International Journal of Occupational Medicine & Environmental Health
Y1 - 2008/04//
VL - 21
IS - 2
M3 - Article
SP - 173
EP - 177
PB - Nofer Institute of Occupational Medicine
SN - 12321087
AB - Objectives: While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease. Materials and Methods: We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers. Results: Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Occupational Medicine & Environmental Health is the property of Nofer Institute of Occupational Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY diseases
KW - OCCUPATIONAL diseases
KW - ASTHMA
KW - FLAVORING essences
KW - POPCORN
KW - ALDEHYDES
KW - Aldehydes
KW - Bronchiolitis obliterans
KW - Flavorings
KW - Occupational asthma
KW - Popcorn
N1 - Accession Number: 33650784; Sahakian, Nancy 1 Kullman, Gregory 1 Lynch, David 2 Kreiss, Kathleen 1; Email Address: KKreiss@cdc.gov; Affiliation: 1: Field Studies Branch, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Department of Radiology, National Jewish Medical and Research Center, Denver, Colorado, USA; Source Info: Apr2008, Vol. 21 Issue 2, p173; Subject Term: RESPIRATORY diseases; Subject Term: OCCUPATIONAL diseases; Subject Term: ASTHMA; Subject Term: FLAVORING essences; Subject Term: POPCORN; Subject Term: ALDEHYDES; Author-Supplied Keyword: Aldehydes; Author-Supplied Keyword: Bronchiolitis obliterans; Author-Supplied Keyword: Flavorings; Author-Supplied Keyword: Occupational asthma; Author-Supplied Keyword: Popcorn; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 311930 Flavoring Syrup and Concentrate Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.2478/v10001-008-0019-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105713905
T1 - Asthma arising in flavoring-exposed food production workers.
AU - Sahakian N
AU - Kullman G
AU - Lynch D
AU - Kreiss K
Y1 - 2008/04//
N1 - Accession Number: 105713905. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 9437093.
KW - Air Pollutants, Occupational -- Poisoning
KW - Asthma -- Chemically Induced
KW - Bronchiolitis Obliterans -- Chemically Induced
KW - Flavoring Agents -- Poisoning
KW - Food Handling
KW - Occupational Diseases
KW - Female
KW - Male
KW - Occupational Exposure
SP - 173
EP - 177
JO - International Journal of Occupational Medicine & Environmental Health
JF - International Journal of Occupational Medicine & Environmental Health
JA - INT J OCCUP MED ENVIRON HEALTH
VL - 21
IS - 2
PB - Nofer Institute of Occupational Medicine
SN - 1232-1087
AD - Centers for Disease Control and Prevention (CDC) Field Studies Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
U2 - PMID: 18715841.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105734724
T1 - A multilevel analysis of state and regional disparities in childhood and adolescent obesity in the United States.
AU - Singh GK
AU - Kogan MD
AU - van Dyck PC
Y1 - 2008/04//
N1 - Accession Number: 105734724. Language: English. Entry Date: 20080606. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7600747.
KW - Obesity -- Evaluation
KW - Pediatric Obesity -- United States
KW - Adolescence
KW - Behavior
KW - Child
KW - Confidence Intervals
KW - Data Analysis Software
KW - Demography
KW - Female
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Physical Activity
KW - Poverty
KW - Socioeconomic Factors
KW - Television
KW - United States
KW - Human
SP - 90
EP - 102
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 33
IS - 2
CY - ,
PB - Springer Science & Business Media B.V.
AB - This study examines state- and regional disparities in obesity prevalence among 46,707 US children and adolescents aged 10-17 years before and after adjusting for individual socioeconomic and behavioral characteristics and area deprivation measures. The 2003 National Survey of Children's Health was used to calculate obesity prevalence in nine geographic regions and in the 50 states and the District of Columbia (DC). Logistic regression was used to estimate odds of obesity and adjusted prevalence. OLS regression was used to determine the amount of variance explained by income inequality, poverty, and violent crime rates. The prevalence of childhood obesity varied substantially across geographic areas, with the Southcentral regions of the US having the highest prevalence (>/=18%) and the Mountain region the lowest prevalence (11.4%). Children in West Virginia, Kentucky, Texas, Tennessee, and North Carolina (adjusted prevalence >18.3%) had over twice the odds of being obese than their Utah counterparts (adjusted prevalence = 10.4%). Geographic disparities in obesity were similar for male and female children. Individual characteristics such as race/ethnicity, household socioeconomic status, neighborhood social capital, television viewing, recreational computer use, and physical activity accounted for 55% of the state and 25% of the regional disparities in obesity. Area poverty rates accounted for an additional 18% of the state variance in adjusted obesity prevalence. Although individual and area level socioeconomic factors are important predictors, substantial geographic disparities in childhood and adolescent obesity remain. Prevention efforts targeting individual risk factors as well as contextual social and environmental factors may reduce geographic disparities in childhood and adolescent obesity.
SN - 0094-5145
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov.
U2 - PMID: 18049885.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105734861
T1 - Direct from CDC. Emergency preparedness and response training for environmental health practitioners.
AU - Miller MD
Y1 - 2008/04//
N1 - Accession Number: 105734861. Language: English. Entry Date: 20080606. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 0405525.
KW - Health Personnel -- Education
KW - Humanitarian Aid -- Education
KW - Professional Development
KW - World Wide Web
SP - 62
EP - 63
JO - Journal of Environmental Health
JF - Journal of Environmental Health
JA - J ENVIRON HEALTH
VL - 70
IS - 8
CY - Denver, Colorado
PB - National Environmental Health Association
SN - 0022-0892
AD - U.S. Public Health Service Senior Environmental Health Officer, National Center for Environmental Health, CDC, 4770 Buford Highway, NE, MS F28, Atlanta, GA 30341; zdq8@cdc.gov
U2 - PMID: 18468226.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Keller, Susanne E.
AU - Shazer, Arlette G.
AU - Fleischman, Gregory J.
AU - Chirtel, Stuart
AU - Anderson, Nathan
AU - Larkin, John
T1 - Modification of the Submerged Coil To Prevent Microbial Carryover Error in Thermal Death Studies.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/04//
VL - 71
IS - 4
M3 - Article
SP - 775
EP - 780
SN - 0362028X
AB - A submerged coil unit generates death rate data for foodborne pathogens through precise computer-controlled sequential sampling rather than the usual manually timed, labor-intensive single sampling associated with other approaches. Our work with Yersinia pseudotuberculosis and Listeria monocytogenes Scott A using the submerged coil unit indicated non--log-linear death rates with large degrees of tailing. Varying degrees of cell adhesion to the surface of the exit port resulted in carryover that was likely the primary cause of these non--log-linear kinetics. This carryover also resulted in erroneously high measured levels of thermal resistance for both organisms. To address the carryover problem, modifications were made to the exit port of the submerged coil unit to ensure continuous and uniform heat treatment. These modifications resulted in a 2-fold decrease in measured D-values for L. monocytogenes Scott A and a 10-fold decrease in measured D-values for Y. pseudotuberculosis. D-values measured with the modified machine for L. monocytogenes Scott A were similar to those found in the literature. Slight tailing in survival curves persisted with the modified method, particularly for Y. pseudotuberculosis. These results indicate that kinetic data for microbial death rates obtained using an unmodified submerged coil unit must be viewed with suspicion in light of the significant potential for carryover. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSIOLOGY
KW - Food pathogens
KW - Cell adhesion
KW - Pathogenic bacteria
KW - Yersinia pseudotuberculosis
KW - Listeria monocytogenes
KW - Effect of heat on microorganisms
N1 - Accession Number: 31728212; Keller, Susanne E. 1; Email Address: susanne.keller@fda.hhs.gov; Shazer, Arlette G. 2; Fleischman, Gregory J. 1; Chirtel, Stuart 3; Anderson, Nathan 1; Larkin, John 1; Affiliations: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501; 2: Illinois Institute of Technology, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501; 3: U.S. Food and Drug Administration, Center for Food Safety and Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Apr2008, Vol. 71 Issue 4, p775; Thesaurus Term: PHYSIOLOGY; Thesaurus Term: Food pathogens; Thesaurus Term: Cell adhesion; Subject Term: Pathogenic bacteria; Subject Term: Yersinia pseudotuberculosis; Subject Term: Listeria monocytogenes; Subject Term: Effect of heat on microorganisms; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105781305
T1 - Extended-spectrum beta-lactamase (ESBL)-producing enterobacteria: factors associated with infection in the community setting, Auckland, New Zealand.
AU - Moor CT
AU - Roberts SA
AU - Simmons G
AU - Briggs S
AU - Morris AJ
AU - Smith J
AU - Heffernan H
Y1 - 2008/04//
N1 - Accession Number: 105781305. Language: English. Entry Date: 20080808. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8007166.
KW - Communities -- New Zealand
KW - Enterobacteriaceae
KW - Infection
KW - Antibiotics
KW - Cardiovascular Diseases
KW - Catheters, Urinary
KW - Electrophoresis, Gel, Pulsed-Field
KW - Escherichia Coli
KW - Logistic Regression
KW - Lung Diseases, Obstructive
KW - Multivariate Analysis
KW - Nervous System Diseases
KW - New Zealand
KW - Nursing Homes
KW - Patient Admission
KW - Univariate Statistics
KW - Urinary Tract Infections
KW - Urine
KW - Human
SP - 355
EP - 362
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
JA - J HOSP INFECT
VL - 68
IS - 4
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - We aimed to document the epidemiology of extended-spectrum beta-lactamase (ESBL)-producing enterobacteria in the Auckland community and identify factors associated with infection using a case-control study design. ESBL-producing enterobacteria were isolated from 107 infected patients, for which demographic and clinical data were available for 98 cases (92%). Escherichia coli was the predominant organism (82%), with urine as the commonest source (97%). Compared with a control group infected with ESBL-negative enterobacteria, factors significantly associated with infection on univariate analysis were: living in a residential care home (RCH); recent admission to hospital 'M'; recent antibiotic use; older age (>75 years); presence of a urinary catheter; and a history of comorbid chronic obstructive pulmonary disease (COPD), cardiovascular disease, neurological disease or recurrent urinary tract infection. On multivariate analysis, residence in RCH and COPD remained significant associations. Pulsed-field gel electrophoresis typing of the ESBL-producing E. coli identified a common strain. We concluded that residence in RCH and a history of COPD are significant associations with ESBL-producing enterobacterial infection in the Auckland community. Several spatial clusters in RCHs and a common strain suggest point-source outbreaks. A substantial number of community cases did not live in an RCH nor had been recently hospitalised, suggesting the independent generation of ESBL-producing enterobacteria in the broader community. Copyright © 2008 The Hospital Infection Society
SN - 0195-6701
AD - Auckland Regional Public Health Service, Auckland, New Zealand.
U2 - PMID: 18353497.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, Stacey E.
AU - Ham, Jason E.
AU - Munson, Albert E.
T1 - Irritancy and Sensitization Potential of Glyoxylic Acid.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2008/04//Apr-Jun2008
VL - 5
IS - 2
M3 - Article
SP - 93
EP - 98
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Glyoxylic acid, a small dicarboxylic acid, has been detected at measurable levels in the atmosphere and is suspected to be present in indoor air environments. It is generated through the ozonolysis of several high volume production compounds that are commonly found indoors. Glyoxylic acid was tested in a combined irritancy and local lymph node assay (LLNA). It tested positive in the LLNA with an EC3 value of 5.05%. Significant increases were observed in the B220+cell population in the draining lymph nodes. No changes were identified in the IgE+B220+ cell population in the draining lymph nodes or total serum IgE levels; this suggests that glyoxylic acid functions as a T-cell-mediated contact sensitizer. Exposure to volatile organic compounds (VOC), similar to glyoxylic acid, emitted from building materials, cleaning formulations or other consumer products, and /or indoor chemistry have been linked to adverse health effects. These results may provide an explanation for some of adverse health effects associated with indoor air exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Indoor air quality
KW - Carboxylic acids
KW - Lymph nodes
KW - B cells
KW - Commercial products
KW - Cells
KW - hypersensitivity
KW - indoor air chemistry
KW - LLNA
KW - respiratory sensitizers
N1 - Accession Number: 34353026; Anderson, Stacey E. 1; Email Address: sanderson4@cdc.gov; Ham, Jason E. 1; Munson, Albert E. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Apr-Jun2008, Vol. 5 Issue 2, p93; Thesaurus Term: Indoor air quality; Subject Term: Carboxylic acids; Subject Term: Lymph nodes; Subject Term: B cells; Subject Term: Commercial products; Subject Term: Cells; Author-Supplied Keyword: hypersensitivity; Author-Supplied Keyword: indoor air chemistry; Author-Supplied Keyword: LLNA; Author-Supplied Keyword: respiratory sensitizers; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/15476910802085681
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Budreau, Lisa M.
T1 - The Politics of Remembrance: The Gold Star Mothers' Pilgrimage and America's Fading Memory of the Great War.
JO - Journal of Military History
JF - Journal of Military History
Y1 - 2008/04//
VL - 72
IS - 2
M3 - Article
SP - 371
EP - 411
SN - 08993718
AB - This essay investigates the American post-First World War commemorative experience and highlights the significance of the war's aftermath on a diverse society, and the process by which a democracy remembers war. It examines the efficacy of government policy regarding the return of American war dead that triggered the Gold Star Mothers' successful efforts to obtain a sponsored pilgrimage overseas. It then asks whether participants truly gained the closure desired. Collectively, these women offer a multidimensional model of ethnic, cultural, economic, and religious diversity prevalent in America during the interwar years while providing scope for exploring racial, gender, and political issues within the context of national mourning. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Military History is the property of Society for Military History and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORLD War, 1914-1918
KW - WOMEN -- Societies & clubs
KW - PILGRIMS & pilgrimages
KW - PRACTICAL politics
KW - POLITICAL science
KW - GOVERNMENT policy
KW - BEREAVEMENT -- Psychological aspects
KW - UNITED States
N1 - Accession Number: 31464051; Budreau, Lisa M. 1; Affiliation: 1: Office of Medical History, Office of The Surgeon General; Source Info: Apr2008, Vol. 72 Issue 2, p371; Subject Term: WORLD War, 1914-1918; Subject Term: WOMEN -- Societies & clubs; Subject Term: PILGRIMS & pilgrimages; Subject Term: PRACTICAL politics; Subject Term: POLITICAL science; Subject Term: GOVERNMENT policy; Subject Term: BEREAVEMENT -- Psychological aspects; Subject Term: UNITED States; NAICS/Industry Codes: 813410 Civic and Social Organizations; Number of Pages: 41p; Illustrations: 3 Black and White Photographs, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Li Qi
AU - Carbone, Kathryn M.
AU - Zhiping Ye
AU - Liu, Teresa
AU - Ovanesov, Mikhail
AU - Pletnikov, Mikhail
AU - Sauder, Christian
AU - Rubin, Steven A.
T1 - Genetic contributions to influenza virus attenuation in the rat brain.
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
Y1 - 2008/04//
VL - 14
IS - 2
M3 - Article
SP - 136
EP - 142
SN - 13550284
AB - Influenza is generally regarded as an infection of the respiratory tract; however, neurological involvement is a well-recognized, although uncommon, complication of influenza A virus infection. The authors previously described the development of a rat model for studying influenza virus infection of the central nervous system (CNS). This model was used here to study the role of virus genes in virus replication and spread in brain. In the present work, an infectious cDNA clone of the neurotoxic WSN strain of influenza virus (rWSN) was altered by site-directed mutagenesis at five loci that corresponded to changes previously shown to confer temperature sensitivity and attenuation of the A/Ann Arbor/6/60 strain (PB1Δ 391, PB1Δ 581, and PB1Δ 661; PB2Δ 265, and NPΔ 34). Whereas rWSN and its mutated derivative (mu-rWSN) replicated equally well in MDCK cells at 37°C (the body temperature of rats), rWSN grew to higher titers and infection was more widespread compared to mu-rWSN in rat brain. These results demonstrate that the five mutations that confer attenuation of the A/Ann Arbor/6/60 influenza virus strain for the respiratory system also confer attenuation for the central nervous system. Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of NeuroVirology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY infections
KW - INFLUENZA
KW - RATS as laboratory animals
KW - GENES
KW - CENTRAL nervous system -- Diseases
KW - attenuation
KW - influenza virus
KW - neurotoxicity
KW - rat
N1 - Accession Number: 31808522; Li Qi 1 Carbone, Kathryn M. 1 Zhiping Ye 1 Liu, Teresa 1 Ovanesov, Mikhail 2 Pletnikov, Mikhail 2 Sauder, Christian 1 Rubin, Steven A. 1; Email Address: rubins@cber.fda.gov; Affiliation: 1: CBER, Food and Drug Administration, Bethesda, Maryland, USA. 2: Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.; Source Info: Apr2008, Vol. 14 Issue 2, p136; Subject Term: RESPIRATORY infections; Subject Term: INFLUENZA; Subject Term: RATS as laboratory animals; Subject Term: GENES; Subject Term: CENTRAL nervous system -- Diseases; Author-Supplied Keyword: attenuation; Author-Supplied Keyword: influenza virus; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: rat; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 3 Graphs; Document Type: Article
L3 - 10.1080/13550280701885563
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31808522&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105904601
T1 - Limiting nurse overtime, and promoting other good working conditions, influences patient safety.
AU - Sharp BAC
AU - Clancy CM
Y1 - 2008/04//Apr-Jun2008
N1 - Accession Number: 105904601. Language: English. Entry Date: 20080502. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Critical Care; Patient Safety; Quality Assurance. NLM UID: 9200672.
KW - Critical Care Nursing
KW - Personnel Staffing and Scheduling
KW - Coronary Care Units
KW - Fatigue
KW - Health Care Errors
KW - Intensive Care Units
KW - Job Satisfaction
KW - Nursing Staff, Hospital
KW - Outcomes (Health Care)
KW - Patient Safety
KW - Quality of Nursing Care
KW - Risk Factors
KW - Work Environment
SP - 97
EP - 100
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 23
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Evidence-based Practice Centers Program, Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 18344773.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105904601&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Turner, Nina L.
AU - Wassell, James T.
AU - Whisler, Richard
AU - Zwiener, Joyce
T1 - Suspension Tolerance in a Full-Body Safety Harness, and a Prototype Harness Accessory.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/04//
VL - 5
IS - 4
M3 - Article
SP - 227
EP - 231
PB - Taylor & Francis Ltd
SN - 15459624
AB - Workers wearing full-body safety harnesses are at risk for suspension trauma if they are not rescued in 5 to 30 min after a successfully arrested fall. Suspension trauma, which may be fatal, occurs when a person's legs are immobile in a vertical posture, leading to the pooling of blood in the legs, pelvis, and abdomen, and the reduction of return blood flow to the heart and brain. To measure suspension tolerance time, 22 men and 18 women with construction experience were suspended from the chest D-ring (CHEST) and back D-ring (BACK) of full-body, fall-arrest harnesses. Fifteen men and 13 women from the original group of subjects were then suspended using a newly developed National Institute for Occupational Safety and Health harness accessory (ACCESS), which supports the upper legs. Midthigh circumference changes were 1.4 and 1.9 cm, changes in minute ventilation were 1.2 and 1.5 L/min, changes in heart rate (HR) were 15.1 and 21.6 bpm, and changes in mean arterial pressure were 5.1 and -2.6 mmHg (p ≤ 0.05) for all subjects during CHEST and BACK, respectively. Kaplan-Meier median suspension time for all subjects for the CHEST condition was 29 min (range 4-60 min) and 31 min (range 5-56 min) for the BACK condition. The 95th percentile for suspension time was 7 min for CHEST and 11 min for BACK. Cox regression revealed that body weight had a statistically significant effect on the time until experiencing a medical end point (p ≤ 0.05) during the BACK condition. Mean (± SD) suspension time was 58 ± 6 min (range 39-60 min) for all subjects for the ACCESS condition. There were no terminations due to medical symptoms during the ACCESS suspension, changes in physiological variables were small, and 85% of ACCESS subjects completed 60-min suspensions. These data provide information on motionless suspension tolerance time to standards-setting organizations and demonstrate the potential of a prototype harness accessory to delay or prevent suspension trauma. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Emotional trauma
KW - Blood
KW - Leg
KW - Pelvis
KW - Abdomen
KW - Blood flow
KW - Heart
KW - Brain
KW - Chest (Anatomy)
KW - orthostatic intolerance
KW - safety harness
KW - suspension trauma
N1 - Accession Number: 32092711; Turner, Nina L. 1; Email Address: nturner@cdc.gov; Wassell, James T. 1; Whisler, Richard 1; Zwiener, Joyce 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia.; Issue Info: Apr2008, Vol. 5 Issue 4, p227; Subject Term: Emotional trauma; Subject Term: Blood; Subject Term: Leg; Subject Term: Pelvis; Subject Term: Abdomen; Subject Term: Blood flow; Subject Term: Heart; Subject Term: Brain; Subject Term: Chest (Anatomy); Author-Supplied Keyword: orthostatic intolerance; Author-Supplied Keyword: safety harness; Author-Supplied Keyword: suspension trauma; Number of Pages: 5p; Illustrations: 1 Black and White Photograph, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620801894386
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092711&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schulte, Paul
AU - Geraci, Charles
AU - Zumwalde, Ralph
AU - Hoover, Mark
AU - Kuempel, Eileen
T1 - Occupational Risk Management of Engineered Nanoparticles.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/04//
VL - 5
IS - 4
M3 - Article
SP - 239
EP - 249
PB - Taylor & Francis Ltd
SN - 15459624
AB - The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Occupational hazards
KW - Industrial hygiene
KW - Protective clothing
KW - Nanoparticles
KW - Work environment
KW - Risk management in business
KW - Public health surveillance
KW - Uncertainty
KW - Nanostructured materials
KW - controls
KW - nanotechnology
KW - particles
KW - risk assessment
KW - risk management
N1 - Accession Number: 32092709; Schulte, Paul 1; Email Address: pas4@cdc.gov; Geraci, Charles 1; Zumwalde, Ralph 1; Hoover, Mark 1; Kuempel, Eileen 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.; Issue Info: Apr2008, Vol. 5 Issue 4, p239; Thesaurus Term: Occupational hazards; Thesaurus Term: Industrial hygiene; Thesaurus Term: Protective clothing; Subject Term: Nanoparticles; Subject Term: Work environment; Subject Term: Risk management in business; Subject Term: Public health surveillance; Subject Term: Uncertainty; Subject Term: Nanostructured materials; Author-Supplied Keyword: controls; Author-Supplied Keyword: nanotechnology; Author-Supplied Keyword: particles; Author-Supplied Keyword: risk assessment; Author-Supplied Keyword: risk management; Number of Pages: 11p; Illustrations: 4 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1080/15459620801907840
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32092709&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105900099
T1 - Suspension tolerance in a full-body safety harness, and a prototype harness accessory.
AU - Turner NL
AU - Wassell JT
AU - Whisler R
AU - Zwiener J
Y1 - 2008/04//
N1 - Accession Number: 105900099. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Accidental Falls
KW - Accidents, Occupational -- Prevention and Control
KW - Immobilization -- Adverse Effects
KW - Occupational Health
KW - Protective Devices -- Adverse Effects
KW - Adult
KW - Blood Pressure
KW - Equipment Design
KW - Ergonomics
KW - Female
KW - Heart Rate
KW - Kaplan-Meier Estimator
KW - Male
KW - Human
SP - 227
EP - 231
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Workers wearing full-body safety harnesses are at risk for suspension trauma if they are not rescued in 5 to 30 min after a successfully arrested fall. Suspension trauma, which may be fatal, occurs when a person's legs are immobile in a vertical posture, leading to the pooling of blood in the legs, pelvis, and abdomen, and the reduction of return blood flow to the heart and brain. To measure suspension tolerance time, 22 men and 18 women with construction experience were suspended from the chest D-ring (CHEST) and back D-ring (BACK) of full-body, fall-arrest harnesses. Fifteen men and 13 women from the original group of subjects were then suspended using a newly developed National Institute for Occupational Safety and Health harness accessory (ACCESS), which supports the upper legs. Midthigh circumference changes were 1.4 and 1.9 cm, changes in minute ventilation were 1.2 and 1.5 L/min, changes in heart rate (HR) were 15.1 and 21.6 bpm, and changes in mean arterial pressure were 5.1 and -2.6 mmHg (p < or = 0.05) for all subjects during CHEST and BACK, respectively. Kaplan-Meier median suspension time for all subjects for the CHEST condition was 29 min (range 4-60 min) and 31 min (range 5-56 min) for the BACK condition. The 95th percentile for suspension time was 7 min for CHEST and 11 min for BACK. Cox regression revealed that body weight had a statistically significant effect on the time until experiencing a medical end point (p < or = 0.05) during the BACK condition. Mean (+/- SD) suspension time was 58 +/- 6 min (range 39-60 min) for all subjects for the ACCESS condition. There were no terminations due to medical symptoms during the ACCESS suspension, changes in physiological variables were small, and 85% of ACCESS subjects completed 60-min suspensions. These data provide information on motionless suspension tolerance time to standards-setting organizations and demonstrate the potential of a prototype harness accessory to delay or prevent suspension trauma.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia 26505, USA. nturner@cdc.gov
U2 - PMID: 18247226.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900099&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105900100
T1 - Occupational risk management of engineered nanoparticles.
AU - Schulte P
AU - Geraci C
AU - Zumwalde R
AU - Hoover M
AU - Kuempel E
Y1 - 2008/04//
N1 - Accession Number: 105900100. Language: English. Entry Date: 20080425. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Nanotechnology -- Adverse Effects
KW - Occupational Exposure -- Prevention and Control
KW - Occupational Health
KW - Risk Management
KW - Environmental Monitoring
KW - Nanotechnology
KW - Protective Clothing
KW - Risk Assessment
KW - Ventilation -- Methods
SP - 239
EP - 249
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 4
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226-1998, USA. pas4@cdc.gov
U2 - PMID: 18260001.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105900100&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Frasch, H. Frederick
AU - Barbero, Ana M.
T1 - The transient dermal exposure: Theory and experimental examples using skin and silicone membranes.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/04//
VL - 97
IS - 4
M3 - Article
SP - 1578
EP - 1592
SN - 00223549
AB - A diffusion model is presented to account for the disposition of chemicals applied to skin as transient exposures. Two conditions are considered that apply to the skin surface following the exposure period, which are applicable to chemicals exhibiting two extremes of chemical volatility. For one case, representing highly volatile compounds, the solution is generalized to apply to multiple transient exposures. For both cases, algebraic expressions are derived to calculate the total amount of chemical that penetrates the skin. The theory is applied to experimental measurements of the in vitro penetration of diethyl phthalate applied to hairless guinea pig (HGP) skin and silicone rubber membranes (SRMs) as transient exposures. The transient exposure theory ably models the experimental data, with coefficients of determination greater than 0.97 (HGP) and greater than 0.99 (SRM). The ability of parameters derived from concurrent infinite dose experiments to predict the time course of absorption from transient exposures is explored. Discrepancies were found between measured cumulative penetration of chemical from transient exposure experiments and penetration predicted from parameters derived from infinite dose experiments, particularly for HGP. Possible reasons are explored. The current model may provide a realistic framework for estimating absorption from occupational, environmental and pharmaceutical dermal exposures. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1578–1592, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - SKIN
KW - ABSORPTION
KW - SOLUTION (Chemistry)
KW - diffusion
KW - mathematical model
KW - membrane transport
KW - passive diffusion/transport
KW - percutaneous
KW - permeability
KW - skin
KW - transdermal
KW - transdermal drug delivery
KW - AMERICAN Pharmacists Association
N1 - Accession Number: 31163480; Frasch, H. Frederick 1; Email Address: hbf9@cdc.gob Barbero, Ana M. 1; Affiliation: 1: Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; Source Info: Apr2008, Vol. 97 Issue 4, p1578; Subject Term: DRUGS; Subject Term: SKIN; Subject Term: ABSORPTION; Subject Term: SOLUTION (Chemistry); Author-Supplied Keyword: diffusion; Author-Supplied Keyword: mathematical model; Author-Supplied Keyword: membrane transport; Author-Supplied Keyword: passive diffusion/transport; Author-Supplied Keyword: percutaneous; Author-Supplied Keyword: permeability; Author-Supplied Keyword: skin; Author-Supplied Keyword: transdermal; Author-Supplied Keyword: transdermal drug delivery; Company/Entity: AMERICAN Pharmacists Association; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 15p; Illustrations: 1 Diagram, 2 Charts, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, D. L.
AU - Cunningham, W. C.
T1 - Compton suppression spectrometry for analysis of short-lived neutron activation products in foods.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2008/04//
VL - 276
IS - 1
M3 - Article
SP - 23
EP - 28
SN - 02365731
AB - Compton suppression spectrometry was used to analyze foods for elements with short-lived neutron activation products (half-lives of about 2 minutes to 1.5 days). Analysis conditions were optimized to provide quality assurance analyses for iodine in FDA’s Total Diet Study. Iodine mass fractions (0.075 to 2.03 mg/kg) were measured in 19 of 42 foods analyzed, with limits of detection (LODs) ranging from 0.03 to 1.4 mg/kg, mostly depending on NaCl content. LODs were lowered by up to a factor of 2 for 16 elements. Suppression factors ranged from about 2 to 8 over the energy range 400 to 3200 keV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPECTROMETRY
KW - GAMMA ray spectrometry
KW - ANGULAR correlations (Nuclear physics)
KW - GAMMA rays
KW - NUCLEAR spectroscopy
KW - RADIOCHEMISTRY
N1 - Accession Number: 31722350; Anderson, D. L. 1; Email Address: david.anderson@fda.hhs.gov Cunningham, W. C. 1; Affiliation: 1: Elemental Research Branch (HFS-338), U. S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Apr2008, Vol. 276 Issue 1, p23; Subject Term: SPECTROMETRY; Subject Term: GAMMA ray spectrometry; Subject Term: ANGULAR correlations (Nuclear physics); Subject Term: GAMMA rays; Subject Term: NUCLEAR spectroscopy; Subject Term: RADIOCHEMISTRY; Number of Pages: 6p; Illustrations: 1 Diagram, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s10967-007-0404-x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31722350&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Join the Fight against Childhood Obesity
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2008/04//
VL - 108
IS - 4
M3 - Editorial
SP - 597
EP - 597
SN - 00028223
AB - The article discusses on how to reduce and prevent childhood overweight and obesity in the U.S. It promotes the Department of Health and Human Services' Childhood Overweight and Obesity Prevention Initiative, which will coordinate and expand the government's existing childhood overweight and obesity prevention programs. This was launched because of the increasing overweight among American children and adolescents. Programmatic interventions that can utilize and adapt to reduce and prevent childhood overweight and obesity include Center for Disease Control and Prevention's School Health Index: A Self-Assessment and Planning Guide and the National Center for Physical Development and Outdoor Play.
KW - PREVENTION of obesity
KW - EATING disorders
KW - OVERWEIGHT persons
KW - OBESITY in adolescence
KW - OBESITY in children
KW - NUTRITION
KW - BODY weight
KW - UNITED States
KW - UNITED States. Dept. of Health & Human Services
N1 - Accession Number: 33318506; Galson, Steven K. 1; Affiliation: 1: Acting US Surgeon General, US Department of Health and Human Services; Source Info: Apr2008, Vol. 108 Issue 4, p597; Subject Term: PREVENTION of obesity; Subject Term: EATING disorders; Subject Term: OVERWEIGHT persons; Subject Term: OBESITY in adolescence; Subject Term: OBESITY in children; Subject Term: NUTRITION; Subject Term: BODY weight; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Health & Human Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2008.02.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33318506&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105761142
T1 - From the Surgeon General. Join the fight against childhood obesity.
AU - Galson SK
Y1 - 2008/04//
N1 - Accession Number: 105761142. Language: English. Entry Date: 20080711. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition; Pediatric Care. NLM UID: 7503061.
KW - Health Promotion
KW - Pediatric Obesity -- Prevention and Control
KW - Adolescence
KW - Child
KW - Health Policy
KW - Information Resources
KW - Obesity -- Epidemiology -- United States
KW - United States
KW - World Wide Web
SP - 597
EP - 597
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 108
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Surgeon General, US Department of Health and Human Services
U2 - PMID: 18375211.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105761142&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Smith, Kent A.
T1 - Laws, leaders, and legends of the modern National Library of Medicine.
JO - Journal of the Medical Library Association
JF - Journal of the Medical Library Association
Y1 - 2008/04//
VL - 96
IS - 2
M3 - Article
SP - 121
EP - 133
PB - Medical Library Association
SN - 15365050
AB - Purpose: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. Brief Description: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements--namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information--transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates--including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper--together contributed to the creation of the modem NLM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Medical Library Association is the property of Medical Library Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL libraries -- History
KW - LEGISLATION
KW - COMMUNICATION in science
KW - COMMUNICATION in medicine
KW - UNITED States
KW - NATIONAL Library of Medicine (U.S.)
KW - NATIONAL Center for Biotechnology Information (U.S.)
N1 - Accession Number: 33160387; Smith, Kent A. 1; Email Address: ksmith@kasenterprise.com; Affiliation: 1: Information Management Consultant and Former Deputy Director, National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894; Source Info: Apr2008, Vol. 96 Issue 2, p121; Subject Term: MEDICAL libraries -- History; Subject Term: LEGISLATION; Subject Term: COMMUNICATION in science; Subject Term: COMMUNICATION in medicine; Subject Term: UNITED States; Company/Entity: NATIONAL Library of Medicine (U.S.) Company/Entity: NATIONAL Center for Biotechnology Information (U.S.); NAICS/Industry Codes: 519120 Libraries and Archives; Number of Pages: 13p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105891644
T1 - Laws, leaders, and legends of the modern National Library of Medicine.
AU - Smith KA
Y1 - 2008/04//
N1 - Accession Number: 105891644. Language: English. Entry Date: 20080418. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Computer/Information Science; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101132728.
KW - Information Retrieval -- History
KW - Libraries -- History
KW - Library Services -- History
KW - National Library of Medicine (U.S.) -- History
KW - Government Regulations -- History
KW - History
KW - Information Retrieval -- Utilization
KW - Libraries -- Utilization
KW - Library Services -- Utilization
KW - National Library of Medicine (U.S.) -- Utilization
KW - United States
SP - 121
EP - 133
JO - Journal of the Medical Library Association
JF - Journal of the Medical Library Association
JA - J MED LIBR ASSOC
VL - 96
IS - 2
CY - Carol Stream, Illinois
PB - Medical Library Association
AB - PURPOSE: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. BRIEF DESCRIPTION: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements--namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information--transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates--including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper-together contributed to the creation of the modern NLM.
SN - 1536-5050
AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894, USA. ksmith@kasenterprise.com
U2 - PMID: 18379667.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105808747
T1 - Fetal ultrasound: mechanical effects.
AU - Stratmeyer ME
AU - Greenleaf JF
AU - Dalecki D
AU - Salvesen KA
Y1 - 2008/04//2008 Apr
N1 - Accession Number: 105808747. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 8211547.
KW - Fetus -- Radiation Effects
KW - Radiation Injuries -- Etiology
KW - Ultrasonography, Prenatal -- Adverse Effects
KW - Animals
KW - Dose-Response Relationship, Radiation
KW - Female
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Radiation Dosage
KW - Risk Assessment
KW - Risk Factors
SP - 597
EP - 605
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
JA - J ULTRASOUND MED
VL - 27
IS - 4
CY - Laurel, Maryland
PB - American Institute of Ultrasound in Medicine
SN - 0278-4297
AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 9200 Corporate Blvd, HFZ-120, Rockville, MD 20850 USA. melvin.stratmeyer@fda.hhs.gov.
U2 - PMID: 18359910.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rakwal, Randeep
AU - Kimura, Shinzo
AU - Shibato, Junko
AU - Nojima, Kumie
AU - Yeon-Ki Kim
AU - Nahm, Baek Hie
AU - Jwa, Nam-Soo
AU - Endo, Satoru
AU - Tanaka, Kenichi
AU - Iwahashi, Hitoshi
T1 - Growth Retardation and Death of Rice Plants Irradiated with Carbon Ion Beams Is Preceded by Very Early Dose- and Time-dependent Gene Expression Changes.
JO - Molecules & Cells (Springer Science & Business Media B.V.)
JF - Molecules & Cells (Springer Science & Business Media B.V.)
Y1 - 2008/04//
VL - 25
IS - 2
M3 - Article
SP - 272
EP - 278
PB - Springer Science & Business Media B.V.
SN - 10168478
AB - The carbon-ion beam (CIB) generated by the heavy-ion medical accelerator in Chiba (HIMAC) was targeted to 7-day-old rice. Physiological parameters such as growth, and gene expression profiles were examined immediately after CIB irradiation. Dose-dependent growth suppression was seen three days post-irradiation (PI), and all the irradiated plants died by 15 days PI. Microarray (Agilent rice 22K) analysis of the plants immediately after irradiation (iai) revealed effects on gene expression at 270 Gy; 353 genes were up-regulated and 87 down-regulated. Exactly the same set of genes was affected at 90 Gy. Among the highly induced genes were genes involved in information storage and processing, cellular processes and signaling, and metabolism. RT-PCR analysis confirmed the microarray data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecules & Cells (Springer Science & Business Media B.V.) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA Microarray
KW - Early Gene Expression
KW - Radiation
KW - Rice
KW - Stress Response
N1 - Accession Number: 96905818; Rakwal, Randeep 1; Email Address: rakwal-68@aist.go.jp Kimura, Shinzo 1,2 Shibato, Junko 1 Nojima, Kumie 1,3 Yeon-Ki Kim 1,4 Nahm, Baek Hie 1,4 Jwa, Nam-Soo 1,5 Endo, Satoru 1,6 Tanaka, Kenichi 1,6 Iwahashi, Hitoshi 1; Affiliation: 1: Human Stress Signal Research Center (HSS), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba West, 16-1 Onogawa, Tsukuba 305-8569, Japan 2: Hazard Assessment and Epidemiology Research Group, Japan National Institute of Occupational Safety and Health (Japan NIOSH), Kawasaki 214-8585, Japan 3: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Inage 263-8555, Japan 4: Division of Bioscience and Bioinformatics, Myongji University, GreenGene BioTech Inc., Yongin 449-728, Korea 5: Department of Molecular Biology, College of Natural Science, Sejong University, Seoul 143-747, Korea 6: Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan; Source Info: 2008, Vol. 25 Issue 2, p272; Author-Supplied Keyword: DNA Microarray; Author-Supplied Keyword: Early Gene Expression; Author-Supplied Keyword: Radiation; Author-Supplied Keyword: Rice; Author-Supplied Keyword: Stress Response; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dwyer, Diane
T1 - Coping with breast pump problems.
JO - Nursing
JF - Nursing
Y1 - 2008/04//
VL - 38
IS - 4
M3 - Article
SP - 25
EP - 25
SN - 03604039
AB - The article presents a discussion on breast pump problems. It discusses a case wherein a mother experienced pains after using a battery-powered breast pump. Experiences of pain are the most common problems reported to the Food and Drug Administration. The article discusses the possible cause of pain and give recommendation on the use of breast pumps.
KW - BREASTFEEDING (Humans)
KW - LACTATION
KW - BREAST milk
KW - MOTHERS
KW - PAIN
N1 - Accession Number: 31699179; Dwyer, Diane 1; Affiliation: 1: Center for Devices and Radiological Health; Source Info: Apr2008, Vol. 38 Issue 4, p25; Subject Term: BREASTFEEDING (Humans); Subject Term: LACTATION; Subject Term: BREAST milk; Subject Term: MOTHERS; Subject Term: PAIN; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105912938
T1 - Device safety. Coping with breast pump problems.
AU - Dwyer D
Y1 - 2008/04//
N1 - Accession Number: 105912938. Language: English. Entry Date: 20080516. Revision Date: 20150820. Publication Type: Journal Article; brief item; questions and answers. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Women's Health. NLM UID: 7600137.
KW - Breast Pumps
KW - Equipment Safety
KW - Nipple Pain -- Etiology
KW - Female
KW - Milk, Human
KW - Patient Education
SP - 25
EP - 25
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 18360231.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105769914
T1 - Dexrazoxane (TOTECT): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy.
AU - Kane RC
AU - McGuinn WD Jr.
AU - Dagher R
AU - Justice R
AU - Pazdur R
Y1 - 2008/04//
N1 - Accession Number: 105769914. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents -- Therapeutic Use
KW - Drug Approval
KW - Extravasation of Diagnostic and Therapeutic Materials -- Drug Therapy
KW - Hydrocarbons, Aromatic -- Adverse Effects
KW - Chemotherapy, Cancer -- Adverse Effects
KW - Denmark
KW - Education, Continuing (Credit)
KW - Necrosis -- Surgery
KW - United States
KW - United States Food and Drug Administration
SP - 445
EP - 450
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 4
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Management of anthracycline extravasation is problematic and most reports are anecdotal. On September 6, 2007, the U.S. Food and Drug Administration approved Totecttrade mark 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy. In two studies, a total of 57 evaluable patients experienced extravasation from peripheral vein or central venous access sites with local swelling, pain, or redness. The presence of anthracycline in skin biopsy tissue was confirmed by tissue fluorescence, and treatment with a 3-day schedule of dexrazoxane began within 6 hours of the event. The primary endpoint was a reduction in the need for surgical intervention. Only one patient required surgical repair of the injury site, and late sequelae in the remainder were absent or mild. Also, the sponsor, TopoTarget A/S, Copenhagen, Denmark, performed controlled nonclinical studies in support of dexrazoxane dose and timing for the reduction of tissue injury resulting from anthracycline extravasation. For this uncommon but serious complication of anthracycline therapy, the need for surgical intervention was 1.7% with this regimen.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Bldg. 22, Room 2109, Silver Spring, Maryland 20993-0002, USA. robert.kane@fda.hhs.gov.
U2 - PMID: 18448560.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hammad, Tarek A.
AU - Graham, David J.
AU - Staffa, Judy A.
AU - Kornegay, Cynthia J.
AU - Dal Pan, Gerald J.
T1 - Onset of acute myocardial infarction after use of non-steroidal anti-inflammatory drugs.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/04//
VL - 17
IS - 4
M3 - Article
SP - 315
EP - 321
SN - 10538569
AB - Purpose To examine the association between cyclooxygenase-2 (COX-2) selective and traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and incident acute myocardial infarction (AMI), and to address unanswered questions regarding the contour of risk over time. Methods A cohort of new NSAID users aged 40-84 years was followed for the occurrence of first AMI. Data were collected within the General Practice Research Database (GPRD) from 1 January 1997 to 31 December 2004. Results The study population included 1185 AMI events (889 probable and 296 possible) from a cohort of 283 136 patients. After adjustment for demographic and cardiovascular risk factors, the hazard ratio (HR) for AMI was significantly increased for both coxib (2.11, 95% confidence interval (CI) 1.04-4.26) and non-coxib (2.24, 95%CI 1.13-4.42) COX-2 selective NSAIDs when compared to remote exposure to NSAIDs, but was not increased for traditional NSAIDs. Stratifying exposure into the first month of use versus use beyond 1 month, the risk of AMI was increased during the first month of COX-2 selective NSAIDs use, but not later (3.43, 95%CI 1.66-7.07 and 1.88, 95%CI 0.82-4.31, respectively p-value for interaction = 0.6). Conclusions The results suggest that the use of coxib and non-coxib COX-2 selective NSAIDs was associated with an elevated risk of AMI within the first month of exposure. Recent past exposure to NSAID was not associated with a similar increase in risk. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707708; Hammad, Tarek A. 1; Graham, David J. 1; Staffa, Judy A. 1; Kornegay, Cynthia J. 1; Dal Pan, Gerald J. 1; Affiliations: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Apr2008, Vol. 17 Issue 4, p315; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1560
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Knudsen, James F.
AU - Sokol, Gerald H.
T1 - Potential Glucosamine-Warfarin Interaction Resulting in Increased International Normalized Ratio: Case Report and Review of the Literature and MedWatch Database.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2008/04//
VL - 28
IS - 4
M3 - Article
SP - 540
EP - 548
SN - 02770008
AB - We describe a 71-year-old man who had received warfarin 7.5 mg/day for 5 years for atrial fibrillation, which had maintained his international normalized ratio (INR) within a narrow range of 2.5-3.2. During this 5-year period, he had also been treating himself with the supplement glucosamine hydrochloride 500 mg--chondroitin sulfate 400 mg twice/day for arthritis. The patient then increased his dosage of glucosamine to 1500 mg and chondroitin to 1200 mg twice/day; his INR previous to this change was 2.3. Approximately 3 weeks later, his INR increased to 3.9. His supplement dosage was reduced to glucosamine 750 mg-chondroitin 600 mg/day; a repeat INR done 16 days later was 4.7. The supplement was then stopped, and his warfarin schedule was changed to 7.5 mg every other day alternating with 3.75 mg every other day. Sixteen days later, his INR was 2.6. This case report suggests that a potential interaction exists between warfarin and glucosamine that is associated with an increase in the INR. We therefore performed a pharmacovigilance survey of spontaneously reported adverse events in warfarin-treated patients concomitantly exposed to glucosamine, glucosamine--chondroitin sulfate, or chondroitin sulfate and present a literature review of this apparent drug-drug interaction. Using the United States Food and Drug Administration (FDA) MedWatch database, 20 reports of glucosamine or glucosamine-chondroitin sulfate use with warfarin associated with altered coagulation (manifested by increased INR, or increased bleeding or bruising) were identified. In some cases, a decrease in the supplement dosage was followed by a return of the INR to the previous therapeutic range. Similarly, a decrease in warfarin dosage was followed by a decrease in INR in one patient who received long-term warfarin therapy. One report described an intraventricular bleed and subdural hematoma, which resulted in a persistent vegetative state. The World Health Organization (WHO) adverse drug reactions database documented 21 spontaneous reports of increased INR associated with glucosamine use, 17 of which resolved when glucosamine was stopped. We located one published case report of concomitant use of glucosamine-chondroitin sulfate potentiating the effect of warfarin. In aggregate, the reports from the FDA and WHO, the published case report, and our case report suggest that the use of warfarin and glucosamine may lead to an increased INR. Patients should be advised that the use of the two products may cause an increase in INR, and they should inform their health care provider if they consume glucosamine. More information is necessary to define this interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCOSAMINE
KW - WARFARIN
KW - CHONDROITIN sulfates
KW - DATABASES
KW - COAGULATION
KW - bleeding
KW - chondroitin sulfate
KW - glucosamine
KW - INR
KW - international normalized ratio
KW - warfarin
N1 - Accession Number: 31753936; Knudsen, James F. 1 Sokol, Gerald H. 2,3; Affiliation: 1: Division of Neurology and Psychiatry Drug Products, Office of Drug Evaluation I, United States Food and Drug Administration, Silver Spring, Maryland 2: Division of Oncology Drug Products, Office of Drug Evaluation I, United States Food and Drug Administration, Silver Spring, Maryland 3: H. Lee Moffin Cancer Center, University of South Florida College of Medicine, Tampa, Florida; Source Info: Apr2008, Vol. 28 Issue 4, p540; Subject Term: GLUCOSAMINE; Subject Term: WARFARIN; Subject Term: CHONDROITIN sulfates; Subject Term: DATABASES; Subject Term: COAGULATION; Author-Supplied Keyword: bleeding; Author-Supplied Keyword: chondroitin sulfate; Author-Supplied Keyword: glucosamine; Author-Supplied Keyword: INR; Author-Supplied Keyword: international normalized ratio; Author-Supplied Keyword: warfarin; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tuzi, Nadia L.
AU - Cancellotti, Enrico
AU - Baybutt, Herbert
AU - Blackford, Lorraine
AU - Bradford, Barry
AU - Plinston, Chris
AU - Coghill, Anne
AU - Hart, Patricia
AU - Piccardo, Pedro
AU - Barron, Rona M.
AU - Manson, Jean C.
T1 - Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection.
JO - PLoS Biology
JF - PLoS Biology
Y1 - 2008/04//
VL - 6
IS - 4
M3 - Article
SP - e100
PB - Public Library of Science
SN - 15449173
AB - The primary determinant of the prion infectious process is the glycosylation status of the host prion protein, PrP. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Biology is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOSYLATION
KW - PROTEIN synthesis
KW - PROTEIN binding
KW - PRION diseases -- Prevention
KW - THERAPEUTICS
KW - SCIENTIFIC method
N1 - Accession Number: 31857610; Tuzi, Nadia L. 1 Cancellotti, Enrico 1 Baybutt, Herbert 1 Blackford, Lorraine 1 Bradford, Barry 1 Plinston, Chris 1 Coghill, Anne 1 Hart, Patricia 1 Piccardo, Pedro 2 Barron, Rona M. 1 Manson, Jean C. 1; Email Address: jean.manson@roslin.ed.ac.uk; Affiliation: 1: Neuropathogenesis Unit, Roslin Institute, Edinburgh, United Kingdom 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America; Source Info: Apr2008, Vol. 6 Issue 4, pe100; Subject Term: GLYCOSYLATION; Subject Term: PROTEIN synthesis; Subject Term: PROTEIN binding; Subject Term: PRION diseases -- Prevention; Subject Term: THERAPEUTICS; Subject Term: SCIENTIFIC method; Number of Pages: 11p; Illustrations: 3 Color Photographs, 1 Black and White Photograph, 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1371/journal.pbio.0060100
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neznanov, Nickolay
AU - Dragunsky, Eugenia M.
AU - Chumakov, Konstantin M.
AU - Neznanova, Lubov
AU - Wek, Ronald C.
AU - Gudkov, Andrei V.
AU - Banerjee, Amiya K.
T1 - Different Effect of Proteasome Inhibition on Vesicular Stomatitis Virus and Poliovirus Replication.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2008/04//
VL - 3
IS - 4
M3 - Article
SP - 1
EP - 12
PB - Public Library of Science
SN - 19326203
AB - Proteasome activity is an important part of viral replication. In this study, we examined the effect of proteasome inhibitors on the replication of vesicular stomatitis virus (VSV) and poliovirus. We found that the proteasome inhibitors significantly suppressed VSV protein synthesis, virus accumulation, and protected infected cells from toxic effect of VSV replication. In contrast, poliovirus replication was delayed, but not diminished in the presence of the proteasome inhibitors MG132 and Bortezomib. We also found that inhibition of proteasomes stimulated stress-related processes, such as accumulation of chaperone hsp70, phosphorylation of eIF2α, and overall inhibition of translation. VSV replication was sensitive to this stress with significant decline in replication process. Poliovirus growth was less sensitive with only delay in replication. Inhibition of proteasome activity suppressed cellular and VSV protein synthesis, but did not reduce poliovirus protein synthesis. Protein kinase GCN2 supported the ability of proteasome inhibitors to attenuate general translation and to suppress VSV replication. We propose that different mechanisms of translational initiation by VSV and poliovirus determine their sensitivity to stress induced by the inhibition of proteasomes. To our knowledge, this is the first study that connects the effect of stress induced by proteasome inhibition with the efficiency of viral infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STOMATITIS
KW - POLIOVIRUS
KW - PHOSPHORYLATION
KW - PROTEIN synthesis
KW - PROTEIN kinases
KW - VIRUS diseases
N1 - Accession Number: 55506809; Neznanov, Nickolay 1; Email Address: neznann@ccf.org Dragunsky, Eugenia M. 2 Chumakov, Konstantin M. 2 Neznanova, Lubov 1 Wek, Ronald C. 3 Gudkov, Andrei V. 4,5 Banerjee, Amiya K. 1; Affiliation: 1: Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America 3: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America 4: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America 5: Cleveland Biolabs, Inc., Buffalo, New York, United States of America; Source Info: 2008, Vol. 3 Issue 4, p1; Subject Term: STOMATITIS; Subject Term: POLIOVIRUS; Subject Term: PHOSPHORYLATION; Subject Term: PROTEIN synthesis; Subject Term: PROTEIN kinases; Subject Term: VIRUS diseases; Number of Pages: 12p; Illustrations: 6 Black and White Photographs, 5 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0001887
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jani, Dewal
AU - Nagarkatti, Rana
AU - Beatty, Wandy
AU - Angel, Ross
AU - Slebodnick, Carla
AU - Andersen, John
AU - Kumar, Sanjai
AU - Rathore, Dharmendar
T1 - HDP--A Novel Heme Detoxification Protein from the Malaria Parasite.
JO - PLoS Pathogens
JF - PLoS Pathogens
Y1 - 2008/04//
VL - 4
IS - 4
M3 - Article
SP - 1
EP - 15
PB - Public Library of Science
SN - 15537366
AB - When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here, we report the identification and characterization of a novel Plasmodium Heme Detoxification Protein (HDP) that is extremely potent in converting heme into Hz. HDP is functionally conserved across Plasmodium genus and its gene locus could not be disrupted. Once expressed, the parasite utilizes a circuitous ''Outbound-Inbound'' trafficking route by initially secreting HDP into the cytosol of infected RBC. A subsequent endocytosis of host cytosol (and hemoglobin) delivers HDP to the food vacuole (FV), the site of Hz formation. As Hz formation is critical for survival, involvement of HDP in this process suggests that it could be a malaria drug target. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Pathogens is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PLASMODIUM
KW - ERYTHROCYTES
KW - CYTOSOL
KW - HEMOGLOBIN polymorphisms
KW - HEME
KW - PROTOZOAN diseases
N1 - Accession Number: 37295080; Jani, Dewal 1 Nagarkatti, Rana 1 Beatty, Wandy 2 Angel, Ross 3 Slebodnick, Carla 4 Andersen, John 5 Kumar, Sanjai 6 Rathore, Dharmendar 1; Email Address: Rathore@vbi.vt.edu; Affiliation: 1: Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America 2: Washington University School of Medicine, St. Louis, Missouri, United States of America 3: Department of Geosciences, Virginia Tech, Blacksburg, Virginia, United States of America 4: Department of Chemistry, Virginia Tech, Blacksburg, Virginia, United States of America 5: Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, Maryland, United States of America 6: Food and Drug Administration, Bethesda, Maryland, United States of America; Source Info: Apr2008, Vol. 4 Issue 4, p1; Subject Term: PLASMODIUM; Subject Term: ERYTHROCYTES; Subject Term: CYTOSOL; Subject Term: HEMOGLOBIN polymorphisms; Subject Term: HEME; Subject Term: PROTOZOAN diseases; Number of Pages: 15p; Illustrations: 2 Black and White Photographs, 3 Diagrams, 2 Graphs; Document Type: Article
L3 - 10.1371/journal.ppat.1000053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Vries, Annemarie C.
AU - Van Driel, Harold F.
AU - Richardus, Jan H.
AU - Ouwendijk, Martine
AU - Van Vuuren, Adriana J.
AU - De Man, Rob A.
AU - Kuipers, Ernst J.
T1 - Migrant communities constitute a possible target population for primary prevention of Helicobacter pylori-related complications in low incidence countries.
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
Y1 - 2008/04//
VL - 43
IS - 4
M3 - Article
SP - 403
EP - 409
SN - 00365521
AB - Objective. Pre-selection of individuals with epidemiological risk factors for Helicobacter pylori infection and atrophic gastritis could increase the efficiency of serologic screening to prevent peptic ulcer disease and gastric cancer in Western countries. The aim of this study was to determine the prevalence of and risk factors for H. pylori infection and atrophic gastritis in a migrant community in The Netherlands. Material and methods. Inhabitants from an urban district in Rotterdam, The Netherlands with a large proportion of immigrants were randomly selected. Information was collected on demographic factors, socio-economic status, lifestyle, history of dyspeptic symptoms and medication use. In addition, serologic H. pylori and CagA status and the presence of atrophic gastritis were evaluated. Results. In total, 288 subjects were included. Surinamese or Antillean, Turkish, Cape Verdian and Moroccan subjects were H. pylori-infected in 65%, 82%, 86% and 96% of cases, respectively, whereas the infection rate in Dutch subjects was 46% (all p<0.05). Within multivariate logistic regression analysis, ethnicity and number of persons in a household were identified as independent risk factors for H. pylori infection. In addition, mean pepsinogen I level and pepsinogen I/II ratio were significantly lower in subjects of non-Dutch origin as compared to Dutch subjects (both p<0.001). No Dutch subjects suffered from atrophic gastritis, as compared with 12 subjects of non-Dutch origin (p=0.13). Conclusions. The prevalence of H. pylori is high in migrant populations in The Netherlands. Furthermore, markers of atrophic gastritis are increased in subjects of foreign origin. Therefore, these migrant communities may constitute a target group for serologic screening to prevent H. pylori-related complications in Western countries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Gastroenterology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HELICOBACTER pylori
KW - EPIDEMIOLOGY -- Research
KW - GASTROENTERITIS
KW - IMMIGRANTS
KW - NETHERLANDS
KW - Atrophic gastritis
KW - gastric cancer
KW - Helicobacter pylori
KW - peptic ulcer
KW - primary prevention
KW - screening
N1 - Accession Number: 31411737; De Vries, Annemarie C. 1; Email Address: A.C.deVries@erasmusmc.nl Van Driel, Harold F. 2 Richardus, Jan H. 2,3 Ouwendijk, Martine 1 Van Vuuren, Adriana J. 1 De Man, Rob A. 1 Kuipers, Ernst J. 1,4; Affiliation: 1: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands. 2: Department of Infectious Diseases Control, Municipal Public Health Service Rotterdam-Rijnmond, The Netherlands. 3: Department of Public Health, Erasmus MC University Medical Center Rotterdam, The Netherlands. 4: Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, The Netherlands.; Source Info: Apr2008, Vol. 43 Issue 4, p403; Subject Term: HELICOBACTER pylori; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: GASTROENTERITIS; Subject Term: IMMIGRANTS; Subject Term: NETHERLANDS; Author-Supplied Keyword: Atrophic gastritis; Author-Supplied Keyword: gastric cancer; Author-Supplied Keyword: Helicobacter pylori; Author-Supplied Keyword: peptic ulcer; Author-Supplied Keyword: primary prevention; Author-Supplied Keyword: screening; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1080/00365520701814077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31411737&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yan, J.
AU - Xia, Q.
AU - Chou, M. W.
AU - Fu, P. P.
T1 - Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.
JO - Toxicology & Industrial Health
JF - Toxicology & Industrial Health
Y1 - 2008/04//
VL - 24
IS - 3
M3 - Article
SP - 181
EP - 188
PB - Sage Publications, Ltd.
SN - 07482337
AB - We have previously reported that metabolism of a series of pyrrolizidine alkaloids in vitro and, in vivo generated a set of (+/-)6,7-dihydro-7-hydroxy-1 -hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. It has also been shown that the levels of the DHP-derived DNA adduct formation correlated closely with the tumorigenic potencies of the mice fed with different doses of riddelliine. Retronecine is the necine base and the structurally smallest chemical of the retronecine-type pyrrolizidine alkaloids. Although it has been reported that microsomal metabolism of retronecine generated DHP as a metabolite, it was yet not known whether metabolism of retronecine in vivo could generate DHP-derived DNA adducts and if formed, whether or not the levels of DNA adducts were comparable with those formed from the other tumorigenic retronecine-type pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline. In this investigation, the in-vitro and in-vivo metabolic activation of retronecine was studied. Rat liver microsomal metabolism of retronecine in the presence of calf thymus DNA resulted in the formation of a set of DHP-DNA adducts. The metabolism of retronecine N-oxide under similar conditions also formed the similar set of DHP-DNA adducts. The level of DNA adducts from retronecine was enhanced when metabolism by liver microsomes from phenobarbital (PB)-induced rats were used. The DHP-DNA adducts were also found in the liver DNA of female F344 rats treated with retronecine or retronecine N-oxide. The highest level of the total DHP-DNA adducts was found in liver DNA from the rats treated with dehydroretronecine (DHR). The order of the levels of DNA adducts in the liver DNA samples from rats treated with various pyrrolizidine alkaloids was: DHR > riddelliine > riddelliine N-oxide >> retronecine > retronecine N-oxide. The results indicate that 1) retronecine can be metabolized to form DHP by rat liver microsomal enzymes and interacts with DNA to produce DHP-DNA adducts and 2) retronecine N-oxide undergoes the biotransformation to the parent compound, retronecine. The results from this and our previous findings strongly suggest that formation of DHP-DNA adducts may be a potential biomarker for pyrrolizidine alkaloid carcinogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology & Industrial Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Methanol
KW - Oncogenic viruses
KW - Biotransformation (Metabolism)
KW - Carcinogenesis
KW - Metabolism
KW - Pyrrolizidines
KW - Monocrotaline
KW - Biliary tract
KW - Alkaloids
KW - Lymphoid tissue
KW - DNA adduct
KW - pyrollizidine alkaloid; retronecine
KW - retronecine N-oxide
N1 - Accession Number: 35825113; Yan, J. 1; Xia, Q.; Chou, M. W. 1; Fu, P. P. 1; Email Address: peter.fu@fda.hhs.gov; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA; Issue Info: Apr2008, Vol. 24 Issue 3, p181; Thesaurus Term: Methanol; Thesaurus Term: Oncogenic viruses; Thesaurus Term: Biotransformation (Metabolism); Thesaurus Term: Carcinogenesis; Subject Term: Metabolism; Subject Term: Pyrrolizidines; Subject Term: Monocrotaline; Subject Term: Biliary tract; Subject Term: Alkaloids; Subject Term: Lymphoid tissue; Author-Supplied Keyword: DNA adduct; Author-Supplied Keyword: pyrollizidine alkaloid; retronecine; Author-Supplied Keyword: retronecine N-oxide; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kornilayev, Boris A.
AU - Alterman, Michail A.
T1 - Utility of polyclonal antibodies targeted toward unique tryptic peptides in the proteomic analysis of cytochrome P450 isozymes
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2008/04//
VL - 22
IS - 3
M3 - Article
SP - 779
EP - 787
SN - 08872333
AB - Abstract: P450s are key enzymes responsible for biotransformation of numerous endogenous and exogenous compounds and are located in almost every tissue. This superfamily is the largest group of enzymes (>6000) that share a high degree of similarity in protein sequence. The human genome contains 57 CYP genes and 58 pseudogenes. A major gap exists in our knowledge about differences in CYP expression on a protein level. DNA and mRNA information are not sufficient because transcription and particularly translation events are not necessarily correlated with levels of expressed proteins. The data reported in this study complete the framework of an integrated proteomic method for the simultaneous qualitative and quantitative analysis of CYP isozyme composition using MALDI–TOF–MS and immunochemistry that has been developed in our laboratory over the last several years () and is based on the fact that each P450 isozyme possesses unique tryptic peptide(s) (UTP) that could be used for differential analysis of human CYP expression. Here we demonstrate that three different immunochemical techniques (ELISA, Western blot, and peptide affinity enrichment on magnetic beads with attached antibodies) have potential to be incorporated in an integrated proteomic method combining mass spectrometry and immunochemistry. Fundamentally, this approach is based on the measurement of the same chemical entity (isozyme-specific UTP) in the tryptic digest by two orthogonal analytical techniques, mass spectrometry and immunochemistry. The application of this approach is illustrated with two human CYP isozymes – CYP1A2 and CYP2E1. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biotransformation (Metabolism)
KW - Cytochrome P-450
KW - Enzymes
KW - Tissues
KW - Proteins
KW - Isoenzymes
KW - Genetic transcription
KW - Immunoglobulins
KW - Anti-peptide antibodies
KW - CYP-cytochrome(s) P450
KW - cytochrome(s) P450 ( CYP )
KW - internal standard ( IS )
KW - MALDI–TOF
KW - mass spectrometry ( MS )
KW - matrix-assisted laser desorption/ionization ( MALDI )
KW - peptide mass fingerprinting ( PMF )
KW - Proteomics
KW - time of flight ( TOF )
N1 - Accession Number: 31249351; Kornilayev, Boris A. 1; Alterman, Michail A. 2; Email Address: Michail.Alterman@fda.hhs.gov; Affiliations: 1: Biochemical Research Service Laboratory, University of Kansas, Lawrence, KS 66047, United States; 2: Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA 8800 Rockville Pike, Building 29A, Room 2D12, HFM-735, Bethesda, MD 20892, United States; Issue Info: Apr2008, Vol. 22 Issue 3, p779; Thesaurus Term: Biotransformation (Metabolism); Thesaurus Term: Cytochrome P-450; Subject Term: Enzymes; Subject Term: Tissues; Subject Term: Proteins; Subject Term: Isoenzymes; Subject Term: Genetic transcription; Subject Term: Immunoglobulins; Author-Supplied Keyword: Anti-peptide antibodies; Author-Supplied Keyword: CYP-cytochrome(s) P450; Author-Supplied Keyword: cytochrome(s) P450 ( CYP ); Author-Supplied Keyword: internal standard ( IS ); Author-Supplied Keyword: MALDI–TOF; Author-Supplied Keyword: mass spectrometry ( MS ); Author-Supplied Keyword: matrix-assisted laser desorption/ionization ( MALDI ); Author-Supplied Keyword: peptide mass fingerprinting ( PMF ); Author-Supplied Keyword: Proteomics; Author-Supplied Keyword: time of flight ( TOF ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tiv.2007.12.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schnackenberg, Laura K.
AU - Beger, Richard D.
T1 - The Role of Metabolic Biomarkers in Drug Toxicity Studies.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2008/04//
VL - 18
IS - 4
M3 - Article
SP - 301
EP - 311
PB - Taylor & Francis Ltd
SN - 15376516
AB - Metabolic profiling is a technique that can potentially provide more sensitive and specific biomarkers of toxicity than the current clinical measures benefiting preclinical and clinical drug studies. Both nuclear magnetic resonance (NMR) and mass spectrometry (MS) platforms have been used for metabolic profiling studies of drug toxicity. Not only can both techniques provide novel biomarker(s) of toxicity but the combination of both techniques gives a broader range of metabolites evaluated. Changes in metabolic patterns can provide insight into mechanism(s) of toxicity and help to eliminate a potentially toxic new chemical entity earlier in the developmental process. Metabolic profiling offers numerous advantages in toxicological research and screening as sample collection and preparation are relatively simple. Further, sample throughput, reproducibility, and accuracy are high. The area of drug toxicity of therapeutic compounds has already been impacted by metabolic profiling studies and will continue to be impacted as new, more specific biomarker(s) are found. In order for a biomarker or pattern of biomarkers to be accepted, it must be shown that they originate from the target tissue of interest. Metabolic profiling studies are amenable to any biofluid or tissue sample making it possible to link the changes noted in urine for instance as originating from renal injury. Additionally, the ease of sample collection makes it possible to follow a single animal or subject over time in order to determine whether and when the toxicity resolves itself. This review focuses on the advantages of metabolic profiling for drug toxicity studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - ANTIMETABOLITES
KW - NUCLEAR magnetic resonance
KW - BIOTRANSFORMATION (Metabolism)
KW - METABOLIC detoxification
KW - TOXICITY testing
KW - MASS spectrometry
KW - NUCLEAR spectroscopy
KW - SPECTRUM analysis
KW - biomarkers
KW - metabolic profiling
KW - metabolomics
KW - metabonomics
KW - toxicity
N1 - Accession Number: 32069518; Schnackenberg, Laura K. 1 Beger, Richard D. 1; Email Address: Richard.Beger@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration Jefferson, AR 72079-9502.; Source Info: Apr2008, Vol. 18 Issue 4, p301; Subject Term: BIOCHEMICAL markers; Subject Term: ANTIMETABOLITES; Subject Term: NUCLEAR magnetic resonance; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: METABOLIC detoxification; Subject Term: TOXICITY testing; Subject Term: MASS spectrometry; Subject Term: NUCLEAR spectroscopy; Subject Term: SPECTRUM analysis; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: metabolic profiling; Author-Supplied Keyword: metabolomics; Author-Supplied Keyword: metabonomics; Author-Supplied Keyword: toxicity; Number of Pages: 11p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15376510701623193
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32069518&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-18081-003
AN - 2008-18081-003
AU - Moore, David F.
AU - Goldin, Ehud
AU - Gelderman, Monique P.
AU - Robinson, Chevalia
AU - Baer, Jessica
AU - Ries, Markus
AU - Elkahloun, Abdel
AU - Brady, Roscoe O.
AU - Schiffmann, Raphael
T1 - Apoptotic abnormalities in differential gene expression in peripheral blood mononuclear cells from children with Fabry disease.
T3 - Natural course, CNS pathophysiology and next targets
JF - Acta Paediatrica
JO - Acta Paediatrica
JA - Acta Paediatr
Y1 - 2008/04//
VL - 97
IS - Suppl457
SP - 48
EP - 52
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0803-5253
SN - 1651-2227
AD - Schiffmann, Raphael, National Institutes of Health, Building 10, Room 3D03, 9000 Rockville Pike, Bethesda, MD, US, 20892-1260
N1 - Accession Number: 2008-18081-003. Other Journal Title: Acta Paediatrica (Sweden); Acta Paediatrica Scandinavica (Sweden). Partial author list: First Author & Affiliation: Moore, David F.; Section of Neurology, University of Manitoba, Winnipeg, MB, Canada. Other Publishers: Almqvist & Wiksell Periodical Co.; Scandinavian University Press; Taylor & Francis. Release Date: 20091130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Apoptosis; Gene Expression; Hormone Therapy; Neurons; Peripheral Neuropathy. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2008. Copyright Statement: Foundation Acta Pædiatrica. 2008.
AB - Aim: This study was designed to examine the effect of enzyme replacement therapy (ERT) on differential gene expression in peripheral blood mononuclear cells (PBMCs) of children with Fabry disease who had not previously been exposed to ERT. Methods: Thirteen children with Fabry disease (age range, 6.5–17.0 years) were studied as part of a 6-month, open-label study of ERT with agalsidase alfa. Paired blood samples were taken at the start of the study and after 6 months of ERT. Further blood samples were also taken from 16 age-matched control subjects. PBMCs were isolated and, following RNA extraction, differential gene expression analysis was performed using the Human Genome U133 Plus 2.0 microarray. Results: Twenty-one genes were determined to be differentially expressed in PBMCs of ERT-naïve children with Fabry disease compared with healthy controls; neuronal apoptosis inhibitory protein ranked as the most significantly differentially expressed gene. Comparison of gene expression in children with Fabry disease prior to and after ERT showed that two genes were significantly differentially expressed (p ≤ 0.05) following treatment; the expressed sequence tag (probe set ID, 243259_at) was downregulated, while expression of apoptosis-inducing factor was increased, possibly as an antioxidant counter-regulatory response. Conclusion: This study identifies a number of genes that are differentially expressed in a small cohort of children with Fabry disease relative to healthy controls. These genes may relate to the underlying biological abnormalities in Fabry disease. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - apoptotic abnormalities
KW - gene expression
KW - peripheral blood mononuclear cells
KW - Fabry disease
KW - enzyme replacement therapy
KW - 2008
KW - Apoptosis
KW - Gene Expression
KW - Hormone Therapy
KW - Neurons
KW - Peripheral Neuropathy
KW - 2008
U1 - Sponsor: National Institute of Neurological Disorders and Stroke, Intramural Programme, US. Recipients: No recipient indicated
DO - 10.1111/j.1651-2227.2008.00654.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18081-003&site=ehost-live&scope=site
UR - ORCID: 0000-0002-5054-5741
UR -
UR - rs4e@nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08665-002
AN - 2008-08665-002
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Haratani, Takashi
AU - Ikeda, Tomoko
AU - Hojou, Minoru
AU - Fujioka, Yosei
AU - Araki, Shunichi
T1 - Association of active and passive smoking with sleep disturbances and short sleep duration among Japanese working population.
JF - International Journal of Behavioral Medicine
JO - International Journal of Behavioral Medicine
JA - Int J Behav Med
Y1 - 2008/04//
VL - 15
IS - 2
SP - 81
EP - 91
CY - United Kingdom
PB - Taylor & Francis
SN - 1070-5503
SN - 1532-7558
AD - Nakata, Akinori, National Institute for Occupational Safety and Health, MS-C24, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-08665-002. PMID: 18569126 Partial author list: First Author & Affiliation: Nakata, Akinori; Institute of Occupational Safety and Health, Kawasaki, Japan. Other Publishers: Lawrence Erlbaum; Springer. Release Date: 20080825. Correction Date: 20100607. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Passive Smoking; Sleep Disorders; Sleep Wake Cycle; Tobacco Smoking. Minor Descriptor: Personnel. Classification: Physiological Processes (2540); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Apr, 2008.
AB - Background: The relationship between passive smoking and sleep is uncertain. Purpose: To examine the association of passive/active smoking with sleep disturbances. Method: 732 women and 1,896 men, working in a suburb of Tokyo, were surveyed using a self-administered questionnaire. Information on smoking, passive smoking exposure, and sleep was elicited. Exposure levels to passive smoking were assessed separately at work and at home as no, occasional, or regular exposure. Risk of sleep disturbances according to smoking status was estimated using logistic regression with odds ratios (OR) and 95% confidence intervals (CIs) as measures of association. Results: Compared to never smokers, odds of difficulty awakening in the morning (DAM) in current smokers were significantly higher for women (OR 1.95) and men (OR 1.50), while increased difficulty initiating sleep (OR 1.88) and decreased early morning awakening (OR 0.31) were found only in women. Never smoking men occasionally exposed to passive smoking at work but not at home had increased odds (OR 1.81) of short sleep duration (SSD, < 6 h) than unexposed counterparts. Conclusions: The analyses suggest that exposure to passive smoking at work is associated with SSD in men, while current smoking relates to various subtypes of sleep disturbances in both sexes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - active smoking
KW - passive smoking
KW - sleep disturbances
KW - sleep duration
KW - Japanese working population
KW - 2008
KW - Passive Smoking
KW - Sleep Disorders
KW - Sleep Wake Cycle
KW - Tobacco Smoking
KW - Personnel
KW - 2008
DO - 10.1080/10705500801929577
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08665-002&site=ehost-live&scope=site
UR - cji5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04859-005
AN - 2008-04859-005
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - van Dyck, Peter C.
T1 - A multilevel analysis of state and regional disparities in childhood and adolescent obesity in the United States.
JF - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JO - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JA - J Community Health
Y1 - 2008/04//
VL - 33
IS - 2
SP - 90
EP - 102
CY - Germany
PB - Springer
SN - 0094-5145
SN - 1573-3610
AD - Singh, Gopal K., Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2008-04859-005. PMID: 18049885 Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Obesity; Pediatrics; Regional Differences. Classification: Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Apr, 2008.
AB - This study examines state- and regional disparities in obesity prevalence among 46,707 US children and adolescents aged 10-17 years before and after adjusting for individual socioeconomic and behavioral characteristics and area deprivation measures. The 2003 National Survey of Children's Health was used to calculate obesity prevalence in nine geographic regions and in the 50 states and the District of Columbia (DC). Logistic regression was used to estimate odds of obesity and adjusted prevalence. OLS regression was used to determine the amount of variance explained by income inequality, poverty, and violent crime rates. The prevalence of childhood obesity varied substantially across geographic areas, with the Southcentral regions of the US having the highest prevalence (≥18%) and the Mountain region the lowest prevalence (11.4%). Children in West Virginia, Kentucky, Texas, Tennessee, and North Carolina (adjusted prevalence>18.3%) had over twice the odds of being obese than their Utah counterparts (adjusted prevalence=10.4%). Geographic disparities in obesity were similar for male and female children. Individual characteristics such as race/ethnicity, household socioeconomic status, neighborhood social capital, television viewing, recreational computer use, and physical activity accounted for 55% of the state and 25% of the regional disparities in obesity. Area poverty rates accounted for an additional 18% of the state variance in adjusted obesity prevalence. Although individual and area level socioeconomic factors are important predictors, substantial geographic disparities in childhood and adolescent obesity remain. Prevention efforts targeting individual risk factors as well as contextual social and environmental factors may reduce geographic disparities in childhood and adolescent obesity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - regional disparities
KW - state disparities
KW - childhood obesity
KW - adolescent obesity
KW - United States
KW - prevalence rate
KW - 2008
KW - Epidemiology
KW - Obesity
KW - Pediatrics
KW - Regional Differences
KW - 2008
DO - 10.1007/s10900-007-9071-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04859-005&site=ehost-live&scope=site
UR - gsingh@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-03768-001
AN - 2008-03768-001
AU - Rosko, Michael D.
AU - Mutter, Ryan L.
T1 - Stochastic frontier analysis of hospital inefficiency: A review of empirical issues and an assessment of robustness.
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2008/04//
VL - 65
IS - 2
SP - 131
EP - 166
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
N1 - Accession Number: 2008-03768-001. PMID: 18045984 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Rosko, Michael D.; Widener University, Chester, PA, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Analysis; Costs and Cost Analysis; Hospitals; Stochastic Modeling. Minor Descriptor: Estimation. Classification: Inpatient & Hospital Services (3379). Population: Human (10). Location: US. Methodology: Literature Review. References Available: Y. Page Count: 36. Issue Publication Date: Apr, 2008.
AB - Twenty stochastic frontier analysis (SFA) studies of hospital inefficiency in the United States were analyzed. Results from best-practice methods were compared against previously used methods in hospital studies to ascertain the robustness of SFA in estimating cost inefficiency. To compare past studies and analyze new data, SFA methods were varied by (a) the assumptions of the structure of costs and distribution of the error term, (b) inclusion of quality and product descriptor measures, and (c) use of simultaneous and two-stage estimation techniques. SFA results were relatively insensitive to several model variations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - stochastic frontier analysis
KW - cost inefficiency
KW - hospital studies
KW - 2008
KW - Analysis
KW - Costs and Cost Analysis
KW - Hospitals
KW - Stochastic Modeling
KW - Estimation
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1177/1077558707307580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03768-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08355-005
AN - 2008-08355-005
AU - Qi, Li
AU - Carbone, Kathryn M.
AU - Ye, Zhiping
AU - Liu, Teresa
AU - Ovanesov, Mikhail
AU - Pletnikov, Mikhail
AU - Sauder, Christian
AU - Rubin, Steven A.
T1 - Genetic contributions to influenza virus attenuation in the rat brain.
JF - Journal of Neurovirology
JO - Journal of Neurovirology
JA - J Neurovirol
Y1 - 2008/04//
VL - 14
IS - 2
SP - 136
EP - 142
CY - US
PB - Informa Healthcare
SN - 1355-0284
SN - 1538-2443
AD - Rubin, Steven A., DVP/OVRR/CBER/FDA, Building 29A, Room 1A-21, 8800 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-08355-005. PMID: 18444085 Partial author list: First Author & Affiliation: Qi, Li; CBER, Food and Drug Administration, Bethesda, MD, US. Other Publishers: Springer; Taylor & Francis. Release Date: 20081208. Correction Date: 20110110. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Central Nervous System; Influenza; Neurotoxicity; Rats. Minor Descriptor: Genetics. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2008.
AB - Influenza is generally regarded as an infection of the respiratory tract; however, neurological involvement is a well-recognized, although uncommon, complication of influenza A virus infection. The authors previously described the development of a rat model for studying influenza virus infection of the central nervous system (CNS). This model was used here to study the role of virus genes in virus replication and spread in brain. In the present work, an infectious cDNA clone of the neurotoxic WSN strain of influenza virus (rWSN) was altered by site-directed mutagenesis at five loci that corresponded to changes previously shown to confer temperature sensitivity and attenuation of the A/Ann Arbor/6/60 strain (PB1Δ391, PBlΔ581, and PB1Δ661; PB2Δ265, and NPΔ34). Whereas rWSN and its mutated derivative (mu-rWSN) replicated equally well in MDCK cells at 37°C (the body temperature of rats), rWSN grew to higher titers and infection was more widespread compared to mu-rWSN in rat brain. These results demonstrate that the five mutations that confer attenuation of the A/Ann Arbor/6/60 influenza virus strain for the respiratory system also confer attenuation for the central nervous system. Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - attenuation
KW - influenza virus
KW - neurotoxicity
KW - rat
KW - central nervous system
KW - genetics
KW - 2008
KW - Brain
KW - Central Nervous System
KW - Influenza
KW - Neurotoxicity
KW - Rats
KW - Genetics
KW - 2008
U1 - Sponsor: US Department of Energy/US Food and Drug Administration, US. Other Details: National Vaccine Program Office administered by the Oak Ridge Institute for Science and Education. Recipients: No recipient indicated
DO - 10.1080/13550280701885563
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08355-005&site=ehost-live&scope=site
UR - rubins@cber.fda.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18187-001
AN - 2008-18187-001
AU - Clancy, Carolyn M.
AU - White, P. Jonathan
T1 - Introduction to the JGIM special issue on health information technology.
JF - Journal of General Internal Medicine
JO - Journal of General Internal Medicine
JA - J Gen Intern Med
Y1 - 2008/04//
VL - 23
IS - 4
SP - 353
EP - 354
CY - Germany
PB - Springer
SN - 0884-8734
SN - 1525-1497
N1 - Accession Number: 2008-18187-001. PMID: 18373128 Partial author list: First Author & Affiliation: Clancy, Carolyn M.; Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Information Technology; Medical Records; Prescribing (Drugs). Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Page Count: 2. Issue Publication Date: Apr, 2008. Copyright Statement: Society of General Internal Medicine. 2008.
AB - For health care to be safe, effective, efficient and reliable, we need to get a lot of things right—including individual clinical decisions about prevention and care for each patient, and the management and policy decisions about how to organize, manage, and pay for that care. As physicians, we recognize that providing the right care to the right patient at the right time—every time—requires knowledge, teamwork, supportive practice environments, and incentives that make the right thing the easy thing to do. In recent years, there has been a dramatically increased interest in the use of health information technology as an essential component of crossing the quality 'chasm'. In fact, health information technology (IT) seems to be everywhere we turn in recent years. Electronic medical records, health information exchange, e-prescribing—the list can get quite long. While there is a dedicated section of the medical community that has studied the subject for decades, health IT has clearly entered the mainstream consciousness of American health care. The articles in this issue address a spectrum of practical and important challenges encountered in efforts to align the potential of health IT with important clinical challenges, and offer enormous insights about the need for closer collaboration between clinicians, health system leaders, vendors, informaticians, systems engineers—and our patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health
KW - information technology
KW - electronic medical records
KW - health information exchange
KW - e-prescribing
KW - 2008
KW - Health
KW - Information Technology
KW - Medical Records
KW - Prescribing (Drugs)
KW - 2008
DO - 10.1007/s11606-008-0562-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18187-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-01561-002
AN - 2008-01561-002
AU - Aekplakorn, Wichai
AU - Hogan, Margaret C.
AU - Tiptaradol, Siriwat
AU - Wibulpolprasert, Suwit
AU - Punyaratabandhu, Porapan
AU - Lim, Stephen S.
T1 - Tobacco and hazardous or harmful alcohol use in Thailand: Joint prevalence and associations with socioeconomic factors.
JF - Addictive Behaviors
JO - Addictive Behaviors
JA - Addict Behav
Y1 - 2008/04//
VL - 33
IS - 4
SP - 503
EP - 514
CY - Netherlands
PB - Elsevier Science
SN - 0306-4603
AD - Aekplakorn, Wichai, Institute for Health Metrics and Evaluation, University of Washington, 1616 Eastlake Avenue E, Suite 300, Seattle, WA, US, 98102
N1 - Accession Number: 2008-01561-002. PMID: 18055131 Partial author list: First Author & Affiliation: Aekplakorn, Wichai; Community Medicine Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Release Date: 20080225. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Epidemiology; Socioeconomic Status; Tobacco Smoking. Minor Descriptor: Hazardous Materials; Risk Factors. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: Thailand. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Apr, 2008.
AB - This study estimates the individual and joint prevalence of cigarette smoking and alcohol misuse, and examines the association between these risks and socioeconomic factors in Thailand. The self-reported data on cigarette and alcohol use are from a 2004 nationally representative cross-sectional survey of 39290 individuals aged 15 and over. Substantially more men than women were current smokers (45.8% vs. 2.3%; p < 0.001) as well as harmful (5.4% vs. 0.9%, p < 0.0001) and hazardous alcohol users (11.2% vs. 1.2%, p < 0.001). The strongest predictor of alcohol misuse was smoking, and the strongest predictor of smoking was alcohol misuse in both sexes. There was an inverse relationship between education and family income with the odds of current smoking, whereas average levels of family income (not low or high) were associated with higher odds of harmful or hazardous alcohol use. Tobacco and alcohol misuse could be more effectively addressed by targeting and tailoring programs towards those who are most at risk--joint tobacco and harmful or hazardous alcohol users, and those of lower socioeconomic status. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - tobacco use
KW - hazardous effects
KW - alcohol use
KW - joint prevalence
KW - socioeconomic factors
KW - cigarette smoking
KW - risk factors
KW - 2008
KW - Alcohol Abuse
KW - Epidemiology
KW - Socioeconomic Status
KW - Tobacco Smoking
KW - Hazardous Materials
KW - Risk Factors
KW - 2008
U1 - Sponsor: Wellcome Trust, United Kingdom. Grant: 071842/Z/03/Z. Recipients: No recipient indicated
U1 - Sponsor: National Health and Medical Research Council, Australia. Grant: 301199. Recipients: No recipient indicated
DO - 10.1016/j.addbeh.2007.10.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-01561-002&site=ehost-live&scope=site
UR - stevelim@u.washington.edu
UR - phppy@mahidol.ac.th
UR - suwit@health.moph.go.th
UR - siriwat@fda.moph.go.th
UR - mchogan@u.washington.edu
UR - rawap@mahidol.ac.th
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05830-002
AN - 2008-05830-002
AU - Waters, Thomas
AU - Genaidy, Ash
AU - Viruet, Heriberto Barriera
AU - Makola, Mbulelo
T1 - The impact of operating heavy equipment vehicles on lower back disorders.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2008/04//
VL - 51
IS - 5
SP - 602
EP - 636
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Waters, Thomas
N1 - Accession Number: 2008-05830-002. PMID: 18432441 Partial author list: First Author & Affiliation: Waters, Thomas; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20080602. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Back Pain; Human Factors Engineering; Musculoskeletal Disorders. Minor Descriptor: Evidence Based Practice; Posture; Working Conditions. Classification: Working Conditions & Industrial Safety (3670); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 35. Issue Publication Date: Apr, 2008.
AB - Literature reviews examining the relationship between heavy equipment vehicle (HEV) operation and the development of musculoskeletal disorders have generally been qualitative in nature and have not employed an evidence-based assessment procedure. This research determines the extent to which whole-body vibration/shock and working postures are associated with lower back and neck disorders among HEV operators, while accounting for individual (i.e. age, gender, prior history of back or neck disorders) and occupational (i.e. material handling, climatic conditions, psychosocial factors) confounders. Published articles were obtained from a search of electronic databases and from bibliographies in the identified articles. A critical appraisal of these articles was conducted using an epidemiological appraisal instrument (Genaidy et al. 2007). The meta-analysis was conducted using statistical techniques employing fixed-effect and random-effect models. Eighteen articles reporting observational studies satisfied the inclusion criteria adopted for this research. The methodological qualities of the published studies ranged from marginal to average. The meta-relative risk was found to be 2.21, indicating that operators exposed to driving HEVs are at more than twice the risk of developing lower back pain in comparison to those not exposed to driving HEVs. Therefore, it seems possible that there is a causal relationship between working as a HEV operator and development of lower back disorders. Prospective cohort studies are urgently needed to confirm the outcomes of this evidence-based methodology (based in part on the meta-analysis) and the biological plausibility should be further explored. The reported findings point to a need for improved ergonomic design of HEVs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - operating heavy equipment vehicles
KW - lower back disorders
KW - musculoskeletal disorders
KW - evidence-based assessment
KW - 2008
KW - Back Pain
KW - Human Factors Engineering
KW - Musculoskeletal Disorders
KW - Evidence Based Practice
KW - Posture
KW - Working Conditions
KW - 2008
DO - 10.1080/00140130701779197
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05830-002&site=ehost-live&scope=site
UR - trwl@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08215-022
AN - 2009-08215-022
AU - Piper, Brian J.
AU - Fraiman, Joseph B.
AU - Owens, Cullen B.
AU - Ali, Syed F.
AU - Meyer, Jerrold S.
T1 - Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2008/04//
VL - 33
IS - 5
SP - 1192
EP - 1205
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
AD - Meyer, Jerrold S., Department of Psychology, University of Massachusetts, Tobin Hall, 135 Hicks Way, Amherst, MA, US, 01003-7710
N1 - Accession Number: 2009-08215-022. PMID: 17609680 Partial author list: First Author & Affiliation: Piper, Brian J.; Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA, US. Release Date: 20100125. Correction Date: 20100510. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Piper, Brian J. Major Descriptor: Citalopram; Dissociation; Methylenedioxymethamphetamine; Neurochemistry; Neurotoxicity. Minor Descriptor: Drug Therapy; Behavioral Neuroscience. Classification: Psychopharmacology (2580). Population: Human (10); Animal (20); Male (30). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Apr, 2008. Publication History: First Posted Date: Jul 4, 2007; Accepted Date: May 24, 2007; Revised Date: May 23, 2007; First Submitted Date: Nov 7, 2006. Copyright Statement: All rights reserved. Nature Publishing Group. 2008.
AB - High or repeated doses of the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’) produce long-lasting deficits in several markers of serotonin (5-HT) system integrity and also alter behavioral function. However, it is not yet clear whether MDMA-induced serotonergic neurotoxicity is responsible for these behavioral changes or whether other mechanisms are involved. The present experiment tested the hypothesis that blocking serotonergic neurotoxicity by pretreatment with the selective 5-HT reuptake inhibitor citalopram will also prevent the behavioral and physiological consequences of an MDMA binge administration. Male, Sprague– Dawley rats (N = 67) received MDMA (4 × 10 mg/kg) with or without citalopram (10 mg/kg) pretreatment. Core temperature, ejaculatory response, and body weight were monitored during and immediately following drug treatments. A battery of tests assessing motor, cognitive, exploratory, anxiety, and social behaviors was completed during a 10-week period following MDMA administration. Brain tissue was collected at 1 and 10 weeks after drug treatments for measurement of regional 5-HT transporter binding and (for the 1- week samples) 5-HT and 5-HIAA concentrations. Citalopram pretreatment blocked MDMA-related reductions in aggressive and exploratory behavior measured in the social interaction and hole-board tests respectively. Such pretreatment also had the expected protective effect against MDMA-induced 5-HT neurotoxicity at 1 week following the binge. In contrast, citalopram did not prevent most of the acute effects of MDMA (eg hyperthermia and weight loss), nor did it block the decreased motor activity seen in the binge-treated animals 1 day after dosing. These results suggest that some of the behavioral and physiological consequences of a high-dose MDMA regimen in rats are mediated by mechanisms other than the drug’s effects on the serotonergic system. Elucidation of these mechanisms requires further study of the influence of MDMA on other neurotransmitter systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dissociation
KW - neurochemical toxicology
KW - behavioral toxicology
KW - citalopram
KW - methylenedioxymethamphetamine
KW - 2008
KW - Citalopram
KW - Dissociation
KW - Methylenedioxymethamphetamine
KW - Neurochemistry
KW - Neurotoxicity
KW - Drug Therapy
KW - Behavioral Neuroscience
KW - 2008
U1 - Sponsor: National Institutes of Health, University of Massachusetts, Neuroscience and Behavior Program, US. Grant: T32 NS007490. Other Details: Training Grant. Recipients: Piper, Brian J.
DO - 10.1038/sj.npp.1301491
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08215-022&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8382-7075
UR -
UR - jmeyer@psych.umass.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Yamaguchi, Yuji
AU - Beer, Janusz Z.
AU - Hearing, Vincent J.
T1 - Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer.
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
Y1 - 2008/04/02/Apr2008 Supplement
VL - 300
M3 - Article
SP - 43
EP - 50
SN - 03403696
AB - Ultraviolet (UV)-induced skin cancers, including melanomas and basal/squamous cell carcinomas, occur more frequently in individuals with fair skin than in those with dark skin. Melanin plays an important role in protecting the skin against UV radiation and levels of melanin correlate inversely with amounts of DNA damage induced by UV in human skin of different racial/ethnic groups. The objectives of this study are to review recent progress in our understanding of mechanisms underlying differences in cancer incidence in skins of different colors, particularly between Black and White skin. More specifically, we review DNA damage and apoptosis in various types of skin before and after exposure to UV in our human study protocols using a single UV dose, either one minimal erythema dose (MED) or a similar low dose of 180–200 J/m2. Our data and other published reports indicate that several major mechanisms underlie the increased rates of photocarcinogenesis in fair/light skin. First, UV-induced DNA damage in the lower epidermis (including keratinocyte stem cells and melanocytes) is more effectively prevented in darker skin. Second, rates of repair of DNA damage can differ significantly in individuals. Third, UV-induced apoptosis to remove potentially precancerous cells is significantly greater in darker skin. These results suggest that pigmented epidermis is an efficient UV filter and that UV damaged cells are removed more efficiently in darker skin. The combination of decreased DNA damage and more efficient removal of UV-damaged cells may play a critical role in the decreased photocarcinogenesis seen in individuals with darker skin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Dermatological Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MELANINS
KW - ULTRAVIOLET radiation
KW - DERMATOLOGY
KW - HUMAN skin color
KW - SKIN -- Cancer
KW - SKIN diseases
KW - Apoptosis
KW - DNA repair
KW - Melanin
KW - Photocarcinogenesis
KW - UV
N1 - Accession Number: 31379735; Yamaguchi, Yuji 1,2,3; Email Address: yujin@med.nagoya-cu.ac.jp Beer, Janusz Z. 4 Hearing, Vincent J. 1; Affiliation: 1: Pigment Cell Research Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Department of Dermatology, Osaka University Graduate School of Medicine, Suita-shi, Osaka, Japan 3: Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya-shi, Aichi, Japan 4: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA; Source Info: Apr2008 Supplement, Vol. 300, p43; Subject Term: MELANINS; Subject Term: ULTRAVIOLET radiation; Subject Term: DERMATOLOGY; Subject Term: HUMAN skin color; Subject Term: SKIN -- Cancer; Subject Term: SKIN diseases; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: DNA repair; Author-Supplied Keyword: Melanin; Author-Supplied Keyword: Photocarcinogenesis; Author-Supplied Keyword: UV; Number of Pages: 8p; Illustrations: 3 Color Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1007/s00403-007-0807-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31379735&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, M. J.
AU - Garrett, R. H.
T1 - Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and ‘histamine dysmetabolism’
JO - Inflammation Research
JF - Inflammation Research
Y1 - 2008/04/02/
VL - 57
IS - 0
M3 - Article
SP - 25
EP - 26
SN - 10233830
AB - The article presents a study on the correlations among tropical endomyocardial fibrosis (T-EMF), eosinophilia, and histamine dysmetabolism. It states that theT-EMF is endemic among the economically backward people residing in areas near the equator. It states that the Endomyocardial fibrosis is common in patients with idiopathic hypereosinophilia.
KW - CARDIOMYOPATHIES
KW - EOSINOPHILIA
KW - HISTAMINE
KW - METABOLIC disorders
KW - POOR people
N1 - Accession Number: 32952229; Smith, M. J. 1; Email Address: mitchell.smith@fda.hhs.gov Garrett, R. H. 2; Affiliation: 1: Office of Center Director, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, 20740 Maryland, USA. 2: Department of Biology, University of Virginia, Charlottesville, 22904 Virginia, USA.; Source Info: Apr2008, Vol. 57 Issue 0, p25; Subject Term: CARDIOMYOPATHIES; Subject Term: EOSINOPHILIA; Subject Term: HISTAMINE; Subject Term: METABOLIC disorders; Subject Term: POOR people; Number of Pages: 2p; Document Type: Article
L3 - 10.1007/s00011-007-0612-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32952229&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, R.B.
AU - Yang, Y.
AU - Khan, M.A.
AU - Faustino, P.J.
T1 - Molecular weight determination for colloidal iron by Taguchi optimized validated gel permeation chromatography
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/04/02/
VL - 353
IS - 1/2
M3 - Article
SP - 21
EP - 27
SN - 03785173
AB - Abstract: Method development of gel permeation chromatography (GPC) is a time-consuming task, since finding appropriate operating conditions has traditionally been a trial-and-error process. A novel approach in the field of GPC using experimental design called Taguchi is presented. This experimental design was used to compare the net effects of various conditions which were both qualitative and quantitative in nature. Quantitative factors included mobile phase pH, flow rate, temperature of column and detector, and injection volume. The qualitative factors were treated as noise which included enclosure of GPC system and position of waste container with respect to refractive index detector. The method was efficient as opposed to a one-factor-at-a-time approach. Taguchi optimized conditions included pH of 7.2, flow rate of 0.4mL/min, temperature of 35°C for column and detector, as well as injection volume of 10μL. The optimized factors yielded acceptable results in terms of weight average molecular weight (m.w.), standard deviation and signal-to-noise ratio. Standard curves were constructed using dextran m.w. standards (12,000–270,000Da) over the analytical range. The method was validated according to ICH guidelines. Log-linear function was used for m.w. standard curve and weight average m.w. was calculated utilizing trapezoidal approach. A correlation coefficient of >0.99 was obtained for both intra-day and inter-day standard calibration curves. Inter-day accuracy ranged from 91 to 108% and precision was <2.0%. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR weights
KW - GEL permeation chromatography
KW - SUCROSE
KW - REFRACTIVE index
KW - Design of experiments
KW - Gel permeation chromatography
KW - Iron sucrose
KW - Taguchi design
KW - Validation
KW - Weight average molecular weight
N1 - Accession Number: 31250889; Shah, R.B. 1 Yang, Y. 1 Khan, M.A. 1 Faustino, P.J.; Email Address: Patrick.Faustino@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave. Silver Spring, MD 20993, USA; Source Info: Apr2008, Vol. 353 Issue 1/2, p21; Subject Term: MOLECULAR weights; Subject Term: GEL permeation chromatography; Subject Term: SUCROSE; Subject Term: REFRACTIVE index; Author-Supplied Keyword: Design of experiments; Author-Supplied Keyword: Gel permeation chromatography; Author-Supplied Keyword: Iron sucrose; Author-Supplied Keyword: Taguchi design; Author-Supplied Keyword: Validation; Author-Supplied Keyword: Weight average molecular weight; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ijpharm.2007.11.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31250889&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Yongsheng
AU - Faustino, Patrick J.
AU - Progar, Joseph J.
AU - Brownell, Charles R.
AU - Sadrieh, Nakissa
AU - May, Joan C.
AU - Leutzinger, Eldon
AU - Place, David A.
AU - Duffy, Eric P.
AU - Yu, Lawrence X.
AU - Khan, Mansoor A.
AU - Lyon, Robbe C.
T1 - Quantitative determination of thallium binding to ferric hexacyanoferrate: Prussian blue
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/04/02/
VL - 353
IS - 1/2
M3 - Article
SP - 187
EP - 194
SN - 03785173
AB - Abstract: Ferric hexacyanoferrate, (Fe4III[FeII(CN)6]3), also known as insoluble Prussian blue (PB), is the active pharmaceutical ingredient (API) of Radiogardase which is the first approved drug product (DP) for treatment of thallium and radiocesium poisoning. The aim of this study is (1) to determine the in vitro thallium binding capacity and binding rates of insoluble PB; and (2) to evaluate the effect of physiological pH conditions, PB particle size and storage conditions on the binding to PB. Experimental pH levels from 1.0 to 7.5 were used to cover the range of pH levels that PB may encounter when traveling through the gastrointestinal (GI) tract in humans. Measurements of thallium binding were made between 1 and 24h, to cover gastric and intestinal tract residence time. PB was found to have a binding capacity of approximately 1400mg/g at pH 7.5. When the pH decreased, the binding decreased as well. The results indicated that the hydration state of PB influences the thallium binding process. It was also found that there exits a direct correlation between the moisture loss in PB and the thallium binding rate constant. The PB with 17mol of water had a binding rate constant of 0.52, which was reduced to 0.32 when PB was dehydrated to 2.5mol of water. Significant differences were observed in both binding capacity and binding rate constant among PB fractions with different particle size ranges. PB fraction with particle size of 220–1000μm had a binding rate constant of 0.43, which increased to 0.64 when the particle size was reduced to 32–90μm. Batch-to-batch variation in thallium binding was also observed among the APIs and the DPs and this was related to particle size and hydration state. These findings can be utilized to evaluate and predict drug product quality under certain manufacturing and dry storage conditions. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - THALLIUM
KW - PRUSSIAN blue
KW - HYDRATION
KW - GASTROINTESTINAL system
KW - Hydration
KW - Moisture loss
KW - Particle size
KW - Product quality
KW - Prussian blue
KW - Thallium binding
N1 - Accession Number: 31250950; Yang, Yongsheng 1 Faustino, Patrick J. 1; Email Address: patrick.faustinop@fda.hhs.gov Progar, Joseph J. 2 Brownell, Charles R. 1 Sadrieh, Nakissa 3 May, Joan C. 2 Leutzinger, Eldon 4 Place, David A. 4 Duffy, Eric P. 4 Yu, Lawrence X. 5 Khan, Mansoor A. 1 Lyon, Robbe C. 1; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Testing and Research, Division of Product Quality Research, Life Science Building-64, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 2: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Laboratory of Analytical Chemistry, 5516 Nicholson Lane, Kensington, MD 20850, United States 3: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Building-21, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 4: Food and Drug Administration, Office of New Drug Quality Assessment, Division of Medical Imaging, Building-22, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 5: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, 7500 Standish Place, Rockville, MD 20855, United States; Source Info: Apr2008, Vol. 353 Issue 1/2, p187; Subject Term: THALLIUM; Subject Term: PRUSSIAN blue; Subject Term: HYDRATION; Subject Term: GASTROINTESTINAL system; Author-Supplied Keyword: Hydration; Author-Supplied Keyword: Moisture loss; Author-Supplied Keyword: Particle size; Author-Supplied Keyword: Product quality; Author-Supplied Keyword: Prussian blue; Author-Supplied Keyword: Thallium binding; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijpharm.2007.11.031
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Morris, Suzanne M.
AU - Akerman, Gregory S.
AU - Desai, Varsha G.
AU - Tsai, Chen-an
AU - Tolleson, William H.
AU - Melchior, William B.
AU - Lin, Chien-Ju
AU - Fuscoe, James C.
AU - Casciano, Daniel A.
AU - Chen, James J.
T1 - Effect of p53 genotype on gene expression profiles in murine liver
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2008/04/02/
VL - 640
IS - 1/2
M3 - Article
SP - 54
EP - 73
SN - 00275107
AB - Abstract: The tumor suppressor protein p53 is a key regulatory element in the cell and is regarded as the “guardian of the genome”. Much of the present knowledge of p53 function has come from studies of transgenic mice in which the p53 gene has undergone a targeted deletion. In order to provide additional insight into the impact on the cellular regulatory networks associated with the loss of this gene, microarray technology was utilized to assess gene expression in tissues from both the p53 −/− and p53 +/− mice. Six male mice from each genotype (p53 +/+, p53 +/−, and p53 −/−) were humanely killed and the tissues processed for microarray analysis. The initial studies have been performed in the liver for which the Dunnett test revealed 1406 genes to be differentially expressed between p53 +/+ and p53 +/− or between p53 +/+ and p53 −/− at the level of p ≤0.05. Both genes with increased expression and decreased expression were identified in p53 +/− and in p53 −/− mice. Most notable in the gene list derived from the p53 +/− mice was the significant reduction in p53 mRNA. In the p53 −/− mice, not only was there reduced expression of the p53 genes on the array, but genes associated with DNA repair, apoptosis, and cell proliferation were differentially expressed, as expected. However, altered expression was noted for many genes in the Cdc42-GTPase pathways that influence cell proliferation. This may indicate that alternate pathways are brought into play in the unperturbed liver when loss or reduction in p53 levels occurs. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENES
KW - RODENTS
KW - HEREDITY
KW - BIOLOGY
KW - Gene expression
KW - Microarray
KW - p53
KW - Real-time quantitative PCR
KW - Transgenic mice
N1 - Accession Number: 31308259; Morris, Suzanne M. 1; Email Address: suzanne.morris@fda.hhs.gov Akerman, Gregory S. 2 Desai, Varsha G. 3 Tsai, Chen-an 4 Tolleson, William H. 5 Melchior, William B. 5 Lin, Chien-Ju 6 Fuscoe, James C. 3 Casciano, Daniel A. 7 Chen, James J. 6; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 2: Toxicology Branch, Health Effects Division (7509P), US Environmental Protection Agency, 1200 Pennsylvania Avenue, NW, Washington, DC 20460, United States 3: Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 4: Biostatistics Center and Department of Public Health, China Medical University, Taichung, 40402, Taiwan 5: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 6: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States 7: Dan Casciano and Associates, 47 Marcella Drive, Little Rock, AR 72233, United States; Source Info: Apr2008, Vol. 640 Issue 1/2, p54; Subject Term: GENES; Subject Term: RODENTS; Subject Term: HEREDITY; Subject Term: BIOLOGY; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: p53; Author-Supplied Keyword: Real-time quantitative PCR; Author-Supplied Keyword: Transgenic mice; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 20p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2007.12.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - John, Kaarthik
AU - Keshava, Channa
AU - Richardson, Diana L.
AU - Weston, Ainsley
AU - Nath, Joginder
T1 - Transcriptional profiles of benzo(a)pyrene exposure in normal human mammary epithelial cells in the absence or presence of chlorophyllin
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2008/04/02/
VL - 640
IS - 1/2
M3 - Article
SP - 145
EP - 152
SN - 00275107
AB - Abstract: Benzo(a)pyrene (BP) exposure causes alterations in gene expression in normal human mammary epithelial cells (NHMECs). This study used Affymetrix Hu-Gene133A arrays, with 14,500 genes represented, to evaluate modulation of BP-induced gene expression by chlorophyllin in six NHMEC strains derived from different donors. A major goal was to seek potential biomarkers of carcinogen exposure and how they behave in the presence of a chemopreventive agent. NHMECs (passage 6 and 70% confluence) were exposed for 24h to either vehicle control, or BP, or chlorophyllin followed by BP and chlorophyllin together. BP exposure resulted in approximately 3-fold altered expression of 49 genes in at least one of the six NHMEC strains. When cells were exposed to chlorophyllin pre-treatment followed by BP plus chlorophyllin, expression of 125 genes was similarly altered. Genes in the functional categories of xenobiotic metabolism, cell signaling, cell motility, cell proliferation, cellular transcription, metabolism, cell cycle control, apoptosis and DNA repair were identified. Only CYP1B1 and ALDH1A3 were consistently up-regulated by ∼3-fold in most of the cell strains (at least 4) when exposed to BP. Cluster analysis identified a suite of 13 genes induced by BP where induction was mitigated in the presence of chlorophyllin. Additionally, cluster analysis identified a suite of 16 genes down-regulated by BP where induction was partially restored in the presence of chlorophyllin. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLS
KW - GENES
KW - HEREDITY
KW - HYDROCARBONS
KW - benzo(a)pyrene ( BP )
KW - Carcinogens
KW - Chemoprevention
KW - Chlorophyllin
KW - cytochrome P450 ( CYP )
KW - Gene expression
KW - normal human mammary epithelial cell ( NHMEC )
KW - polycyclic aromatic hydrocarbon ( PAH )
KW - Polycyclic aromatic hydrocarbons
N1 - Accession Number: 31308269; John, Kaarthik 1,2 Keshava, Channa 2 Richardson, Diana L. 2 Weston, Ainsley 1,2 Nath, Joginder 1; Email Address: jnath@wvu.edu; Affiliation: 1: Genetics and Developmental Biology Program, 1120 Agricultural Sciences Building, West Virginia University, Morgantown, WV 26506-6108, United States 2: Toxicology and Molecular Biology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, United States; Source Info: Apr2008, Vol. 640 Issue 1/2, p145; Subject Term: CELLS; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: HYDROCARBONS; Author-Supplied Keyword: benzo(a)pyrene ( BP ); Author-Supplied Keyword: Carcinogens; Author-Supplied Keyword: Chemoprevention; Author-Supplied Keyword: Chlorophyllin; Author-Supplied Keyword: cytochrome P450 ( CYP ); Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: normal human mammary epithelial cell ( NHMEC ); Author-Supplied Keyword: polycyclic aromatic hydrocarbon ( PAH ); Author-Supplied Keyword: Polycyclic aromatic hydrocarbons; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2008.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105757708
T1 - Endpoints for assessing drug activity in clinical trials.
AU - Pazdur R
Y1 - 2008/04/02/Apr2008 Supplement 2
N1 - Accession Number: 105757708. Language: English. Entry Date: 20080704. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Apr2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Chemotherapy, Cancer -- Evaluation
KW - Clinical Trials
KW - Sarcoma -- Radiography
KW - Treatment Outcomes -- Evaluation
KW - Disease Progression
KW - Survival
KW - Time Factors
KW - Treatment Failure
SP - 19
EP - 21
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Overall survival remains the gold standard for the demonstration of clinical benefit. An improvement in overall survival is a direct clinical benefit to patients. An analysis of overall survival requires larger patient numbers and longer follow-up than other endpoints. Survival analysis may be confounded by subsequent therapies. Time to progression usually requires smaller clinical trials and may be more rapidly assessed than trials using overall survival as an endpoint. This endpoint is not confounded by subsequent therapies. Time to progression must use the same evaluation techniques and schedules for all therapies being evaluated. Blinding of trials or the use of an external blinded radiographic review committee is recommended in assessing time to progression. Unlike overall survival and time to progression, which must be evaluated in randomized trials, response rates can be accurately assessed using a single-arm trial. Stable disease is not included in a response rate determination and is optimally evaluated by assessing tumor progression in a randomized trial. Improvement in disease-related symptoms is considered clinical benefit and may be an appropriate endpoint for drug approval.
SN - 1083-7159
AD - Center for Drug Evaluation Research, U.S. Food and Drug Administration, Rockville, Maryland, USA
U2 - PMID: 18434634.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cieślak, Jacek
AU - Grajkowski, Andrzej
AU - Kauffman, Jon S.
AU - Duff, Robert J.
AU - Beaucage, Serge L.
T1 - The 4-(N-Dichloroacetyl-N-methylamino)benzyloxymethyl Group for 2'-Hydroxyl Protection of Ribonucleosides in the Solid-Phase Synthesis of Oligoribonucleotides.
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
Y1 - 2008/04/04/
VL - 73
IS - 7
M3 - Article
SP - 2774
EP - 2783
SN - 00223263
AB - Emerging RNA-based technologies for controlling gene expression have triggered a high demand for synthetic oligoribonucleotides and have motivated the development of ribonucleoside phosphoramidites that would exhibit coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites. To fulfill these needs, the novel 4-(N-dichloroacetyl-N-methylamino)benzyloxymethyl group for 2'-hydroxyl protection of ribonucleoside phosphoramidites 9a-d has been implemented (Schemes 1 and 2). The solid-phase synthesis of AUCCGUAGCUAACGUCAUGG was then carried out employing 9a-d as 0.2 M solutions in dry MeCN and 5-benzylthio-1H-tetrazole as an activator. The coupling efficiency of 9a-d averaged 99% within a coupling time of 180 s. Following removal of all base- sensitive protecting groups, cleavage of the remaining 2'-[4-(N-methylamino)benzyl] acetals from the RNA oligonucleotide was effected in buffered 0.1 M AcOH (pH 3.8) within 30 mm at 90 °C. RP-HPLC and PAGE analyses of the fully deprotected AUCCGUAGCUAACGUCAUGG were comparable to those of a commercial RNA oligonucleotide sharing an identical sequence. Enzymatic digestion of the RNA oligomer catalyzed by bovine spleen phosphodiesterase and bacterial alkaline phosphatase revealed no significant amounts of RNA fragments containing (2'-~5')-internucleotidic phosphodiester linkages or noteworthy nucleobase modifications. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Organic Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA synthesis
KW - ORGANONITROGEN compounds
KW - SOLID-phase synthesis
KW - OLIGOMERS
KW - CATALYSIS
N1 - Accession Number: 31830609; Cieślak, Jacek 1 Grajkowski, Andrzej 1 Kauffman, Jon S. 2 Duff, Robert J. 2 Beaucage, Serge L. 1; Email Address: serge.beaucage@fda.hhs.gov; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 2: Lancaster Laboratories, 2425 New Holland Pike, Lancaster, Pennsylvania 17605-2425; Source Info: 4/4/2008, Vol. 73 Issue 7, p2774; Subject Term: RNA synthesis; Subject Term: ORGANONITROGEN compounds; Subject Term: SOLID-phase synthesis; Subject Term: OLIGOMERS; Subject Term: CATALYSIS; Number of Pages: 10p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1021/jo702717g
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Jennie H.
AU - Dong, Ren G.
AU - Rakheja, Subhash
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
AU - Wu, John Z.
T1 - A method for analyzing absorbed power distribution in the hand and arm substructures when operating vibrating tools
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2008/04/08/
VL - 311
IS - 3-5
M3 - Article
SP - 1286
EP - 1304
SN - 0022460X
AB - Abstract: In this study it was hypothesized that the vibration-induced injuries or disorders in a substructure of human hand–arm system are primarily associated with the vibration power absorption distributed in that substructure. As the first step to test this hypothesis, the major objective of this study is to develop a method for analyzing the vibration power flow and the distribution of vibration power absorptions in the major substructures (fingers, palm–hand–wrist, forearm and upper arm, and shoulder) of the system exposed to hand-transmitted vibration. A five-degrees-of-freedom model of the system incorporating finger- as well as palm-side driving points was applied for the analysis. The mechanical impedance data measured at the two driving points under four different hand actions involving 50N grip-only, 15N grip and 35N push, 30N grip and 45N push, and 50N grip and 50N push, were used to identify the model parameters. The vibration power absorption distributed in the substructures were evaluated using vibration spectra measured on many tools. The frequency weightings of the distributed vibration power absorptions were derived and compared with the weighting defined in ISO 5349-1 (2001). This study found that vibration power absorption is primarily distributed in the arm and shoulder when operating low-frequency tools such as rammers, while a high concentration of vibration power absorption in the fingers and hand is observed when operating high-frequency tools, such as grinders. The vibration power absorption distributed in palm–wrist and arm is well correlated with the ISO-weighted acceleration, while the finger vibration power absorption is highly correlated with unweighted acceleration. The finger vibration power absorption-based frequency weighting suggested that exposure to vibration in the frequency range of 16–500Hz could pose higher risks of developing finger disorders. The results support the use of the frequency weighting specified in the current standard for assessing risks of developing disorders in the palm–wrist–arm substructures. The standardized weighting, however, could overestimate low-frequency effects but greatly underestimate high-frequency effects on the development of finger disorders. The results are further discussed to show that the trends observed in the vibration power absorptions distributed in the substructures are consistent with some major findings of various physiological and epidemiological studies, which provides a support to the hypothesis of this study. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ABSORPTION
KW - PHYSICAL & theoretical chemistry
KW - VIBRATIONAL spectra
KW - SPECTRUM analysis
KW - MOLECULAR spectra
KW - VIBRATION (Mechanics)
N1 - Accession Number: 30027464; Dong, Jennie H. 1 Dong, Ren G. 2; Email Address: rkd6@cdc.gov Rakheja, Subhash 1 Welcome, Daniel E. 2 McDowell, Thomas W. 2 Wu, John Z. 2; Affiliation: 1: Department of Mechanical Engineering, CONCAVE Research Centre, Concordia University, 1455 de Maisonneuve Blvd. West, Montreal, Canada 2: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, WV 26505, USA; Source Info: Apr2008, Vol. 311 Issue 3-5, p1286; Subject Term: ABSORPTION; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: VIBRATIONAL spectra; Subject Term: SPECTRUM analysis; Subject Term: MOLECULAR spectra; Subject Term: VIBRATION (Mechanics); Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.jsv.2007.10.031
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vugia, D.
AU - Tobin-D'Angelo, M.
AU - Blythe, D.
AU - Smith, K.
AU - Lathrop, S.
AU - Morse, D.
AU - Cieslak, P.
AU - Dunn, J.
AU - White, P. L.
AU - Henao, O. L.
AU - Hoekstra, R. M.
AU - Scallan, E.
AU - Angulo, F. J.
AU - Griffin, P. M.
AU - Tauxe, R. V.
AU - Behravesh, C. Barton
AU - Cronquist, A.
AU - Hadler, J.
AU - Guzewich, J. J.
T1 - Preliminary FoodNet Data on the Incidence of Infection with Pathogens Transmitted Commonly Through Food -- 10 States, 2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/04/11/
VL - 57
IS - 14
M3 - Article
SP - 366
EP - 370
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - This article describes preliminary surveillance data for 2007 accumulated by the Foodborne Diseases Active Surveillance Network of the U.S. Centers for Disease Control and Prevention. The data showed that the foodborne diseases are caused by Campylobacter, Listeria, Shiga toxin-producing Escherichia coli O157, Salmonella, Shigella, Vibrio and Yersinia. The data also revealed that Cryptosporidium infections increased in 2007 compared with 2004-2006.
KW - FOODBORNE diseases
KW - DISEASES -- Causes & theories of causation
KW - CAMPYLOBACTER
KW - ESCHERICHIA coli
KW - LISTERIA
KW - SALMONELLA
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 32197793; Vugia, D. 1 Tobin-D'Angelo, M. 2 Blythe, D. 3 Smith, K. 4 Lathrop, S. 5 Morse, D. 6 Cieslak, P. 7 Dunn, J. 8 White, P. L. 9 Henao, O. L. 10 Hoekstra, R. M. 10 Scallan, E. 10 Angulo, F. J. 10 Griffin, P. M. 10 Tauxe, R. V. 10 Behravesh, C. Barton 11 Cronquist, A. 12 Hadler, J. 13 Guzewich, J. J. 14; Affiliation: 1: California Dept of Public Health 2: Div of Public Health, Georgia Dept of Human Resources 3: Maryland Dept of Health and Mental Hygiene 4: Minnesota Dept of Health 5: New Mexico Dept of Health 6: New York State Dept of Health 7: Oregon Public Health Div. 8: Tennessee Dept of Health 9: Food Safety and Inspection Svc, US Dept of Agriculture 10: Div of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases 11: EIS Officer 12: Colorado Dept of Public Health and Environment 13: Connecticut Dept of Public Health 14: Center for Food Safety and Applied Nutrition, Food and Drug Admin.; Source Info: 4/11/2008, Vol. 57 Issue 14, p366; Subject Term: FOODBORNE diseases; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: CAMPYLOBACTER; Subject Term: ESCHERICHIA coli; Subject Term: LISTERIA; Subject Term: SALMONELLA; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Howe, Robin A.
T1 - Don't include trimethoprim.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2008/04/12/
VL - 336
IS - 7648
M3 - Letter
SP - 787
EP - 787
SN - 09598146
AB - A letter to the editor is presented in response to the article "Over the Counter Medicines: Proceed With Caution" by R. E. Fermer and K. Beard in the March 29, 2008 issue.
KW - LETTERS to the editor
KW - PHARMACEUTICAL industry
N1 - Accession Number: 31728495; Howe, Robin A. 1; Email Address: rob¡n.howe@nphs.wales.nhs.uk; Affiliation: 1: head, Welsh Antimicrobial Resistance Programme, National Public Health Service for Wales, Cardiff Microbiology (Velindre NHS Trust), University Hospital of Wales, Cardiff CF14 4XW; Source Info: 4/12/2008, Vol. 336 Issue 7648, p787; Subject Term: LETTERS to the editor; Subject Term: PHARMACEUTICAL industry; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2/3p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105912452
T1 - Let patients control the purse strings.
AU - Alakeson V
Y1 - 2008/04/12/
N1 - Accession Number: 105912452. Language: English. Entry Date: 20080516. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866.
KW - Consumer Participation -- Economics
KW - National Health Programs -- Economics
KW - Budgets
KW - Financing, Organized
KW - Florida
KW - Great Britain
KW - Patient Centered Care -- Economics
KW - Self Care -- Economics
KW - Social Work -- Economics
SP - 807
EP - 809
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
JA - BMJ
VL - 336
IS - 7648
PB - BMJ Publishing Group
SN - 0959-8146
AD - Office of the Assistant Secretary for Planning and Evaluation, Department of Health and Human Services, Humphrey Building, 200 Independence Avenue SW, Washington, DC 20201, USA. vidhya.alakeson@hhs.gov
U2 - PMID: 18403545.
DO - 10.1136/bmj.39524.400498.AD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105912452&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Allen LaPointe, Nancy M.
AU - Sun, Jie-Lena
AU - Kaplan, Sigal
AU - d’Almada, Phil
AU - Al-Khatib, Sana M.
T1 - Rhythm Versus Rate Control in the Contemporary Management of Atrial Fibrillation In-Hospital † [†] The views expressed in this report are those of the investigators and do not necessarily represent the views of the FDA.
JO - American Journal of Cardiology
JF - American Journal of Cardiology
Y1 - 2008/04/15/
VL - 101
IS - 8
M3 - Article
SP - 1134
EP - 1141
SN - 00029149
AB - Little is presently known regarding whether a rhythm-control or a rate-control strategy is more frequently used in patients hospitalized for atrial fibrillation (AF). This study was conducted to assess patient and physician characteristics associated with each treatment strategy and with the use of anticoagulants. Hospitalizations for primary diagnoses of AF were examined using hospital claims from January 2000 to December 2004. Patients who received antiarrhythmic drugs, ablation, or cardioversion for AF were categorized as receiving rhythm control. Patients managed only with β blockers, calcium channel blockers, or digoxin were categorized as receiving rate control. Characteristics associated with rhythm compared with rate control and anticoagulant use with CHADS2 score were determined. The study cohort included 155,731 hospitalizations from 464 hospitals. Of these, 75,397 (48%) were categorized as involving rhythm control and 80,334 (52%) as involving rate control. Care by a noncardiologist (adjusted odds ratio [OR] 0.33, 95% confidence interval [CI] 0.31 to 0.36) and increasing age >65 years (adjusted OR 0.87, 95% CI 0.86 to 0.88) were associated with lower odds of rhythm versus rate control; hypertrophic cardiomyopathy was associated with greater odds (adjusted OR 2.3, 95% CI 1.81 to 2.84) of rhythm control. Warfarin use was greater in the rhythm-control group compared with the rate-control group (adjusted OR 1.56, 95% CI 1.52 to 1.60), and warfarin use was greater with a CHADS2 score ≥2 (unadjusted OR 1.21, 95% CI 1.19 to 1.24). In conclusion, rhythm- and rate-control strategies were used equally in patients hospitalized for AF. Some observations, such as greater use of the rate-control strategy with increasing age, were consistent with recommendations, but others, such as lower use of warfarin in the rate-control group, were not. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Cardiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPERTROPHIC cardiomyopathy
KW - CARDIOMYOPATHIES
KW - ATRIAL fibrillation
KW - WARFARIN
N1 - Accession Number: 31580787; Allen LaPointe, Nancy M. 1; Email Address: allen003@mc.duke.edu Sun, Jie-Lena 1 Kaplan, Sigal 2 d’Almada, Phil 1 Al-Khatib, Sana M. 1; Affiliation: 1: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 2: United States Food and Drug Administration (FDA), Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Silver Spring, Maryland.; Source Info: Apr2008, Vol. 101 Issue 8, p1134; Subject Term: HYPERTROPHIC cardiomyopathy; Subject Term: CARDIOMYOPATHIES; Subject Term: ATRIAL fibrillation; Subject Term: WARFARIN; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.amjcard.2007.11.067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31580787&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sung, R. S.
AU - Galloway, J.
AU - Tuttle-Newhall, J. E.
AU - Mone, T.
AU - Laeng, R.
AU - Freise, C. E.
AU - Rao, P. S.
T1 - Organ Donation and Utilization in the United States, 1997–2006.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2008/04/15/
VL - 8
IS - 4p2
M3 - Article
SP - 922
EP - 934
PB - Wiley-Blackwell
SN - 16006135
AB - Deceased organ donation has increased rapidly since 2002, coinciding with implementation of the Organ Donation Breakthrough Collaborative. The increase in donors has resulted in a corresponding increase in the numbers of kidney, liver, lung and intestinal transplants. While transplants for most organs have increased, discard and nonrecovery rates have not improved or have increased, resulting in a decrease in organs recovered per donor (ORPD) and organs transplanted per donor (OTPD). Thus, the expansion of the consent and recovery of incremental donors has frequently outpaced utilization. Meaningful increases in multicultural donation have been achieved, but donations continue to be lower than actual rates of transplantation and waiting list registrations for these groups. To counteract the decline in living donation, mechanisms such as paired donation and enhanced incentives to organ donation are being developed. Current efforts of the collaborative have focused on differentiating ORPD and OTPD targets by donor type (standard and expanded criteria donors and donors after cardiac death), utilization of the OPTN regional structure and enlisting centers to increase transplants to match increasing organ availability. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DONATION of organs, tissues, etc.
KW - ORGAN donors
KW - TRANSPLANTATION of organs, tissues, etc.
KW - OUTCOME assessment (Medical care)
KW - UNITED States
KW - Deceased donors
KW - donation after cardiac death (DCD)
KW - donation service area (DSA)
KW - expanded criteria donor (ECD)
KW - living donor
KW - multicultural donation
KW - Organ Donation Breakthrough Collaborative
KW - Organ Procurement and Transplantation Network (OPTN)
KW - organ procurement organization (OPO)
KW - Organ Transplantation Breakthrough Collaborative
KW - organs recovered per donor (ORPD)
KW - organs transplanted per donor (OTPD)
KW - Scientific Registry of Transplant Recipients (SRTR)
N1 - Accession Number: 31228674; Sung, R. S. 1; Email Address: rssung@med.umich.edu Galloway, J. 2 Tuttle-Newhall, J. E. 3 Mone, T. 4 Laeng, R. 5 Freise, C. E. 6 Rao, P. S. 1; Affiliation: 1: Scientific Registry of Transplant Recipients, University of Michigan, Ann Arbor, MI 2: Scientific Registry of Transplant Recipients, Arbor Research Collaborative for Health, Ann Arbor, MI 3: Duke University Health System, Durham, NC 4: OneLegacy, Los Angeles, CA 5: Department of Health and Human Services, Health Resources and Services Administration, Rockville, MD 6: University of California San Francisco, San Francisco, CA; Source Info: Apr2008, Vol. 8 Issue 4p2, p922; Subject Term: DONATION of organs, tissues, etc.; Subject Term: ORGAN donors; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: OUTCOME assessment (Medical care); Subject Term: UNITED States; Author-Supplied Keyword: Deceased donors; Author-Supplied Keyword: donation after cardiac death (DCD); Author-Supplied Keyword: donation service area (DSA); Author-Supplied Keyword: expanded criteria donor (ECD); Author-Supplied Keyword: living donor; Author-Supplied Keyword: multicultural donation; Author-Supplied Keyword: Organ Donation Breakthrough Collaborative; Author-Supplied Keyword: Organ Procurement and Transplantation Network (OPTN); Author-Supplied Keyword: organ procurement organization (OPO); Author-Supplied Keyword: Organ Transplantation Breakthrough Collaborative; Author-Supplied Keyword: organs recovered per donor (ORPD); Author-Supplied Keyword: organs transplanted per donor (OTPD); Author-Supplied Keyword: Scientific Registry of Transplant Recipients (SRTR); Number of Pages: 13p; Illustrations: 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2008.02171.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31228674&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Leichtman, A. B.
AU - Cohen, D.
AU - Keith, D.
AU - O'Connor, K.
AU - Goldstein, M.
AU - McBride, V.
AU - Gould, C. J.
AU - Christensen, L. L.
AU - Ashby, V. B.
T1 - Kidney and Pancreas Transplantation in the United States, 1997–2006: The HRSA Breakthrough Collaboratives and the 58 DSA Challenge.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2008/04/15/
VL - 8
IS - 4p2
M3 - Article
SP - 946
EP - 957
PB - Wiley-Blackwell
SN - 16006135
AB - Growth in the number of active patients on the kidney transplant waiting list has slowed. Projections based on the most recent 5-year data suggest the total waiting list will grow at a rate of 4138 registrations per year, whereas the active waiting list will increase at less than one-sixth that rate, or 663 registrations per year. The last 5 years have seen a small trend toward improved unadjusted allograft survival for living and deceased donor kidneys. Since 2004 the overall number of pancreas transplants has declined. Among pancreas recipients, those with simultaneous kidney-pancreas transplants experienced the highest pancreas graft survival rates. In response to the ongoing shortage of deceased donor organs, the US Health Resources and Services Administration launched the Organ Donation Breakthrough Collaborative in September 2003 and the Organ Transplantation Breakthrough Collaborative (OTBC) in October 2005. The 58 DSA Challenge is prominent among the goals adopted by the OTBC. Its premise: were each of the 58 existing donation service areas to increase the number of kidney transplants performed within their boundaries by 10 per month, an additional 7000 transplants over current annual levels would result. Such an increase could potentially eliminate the national kidney transplantation waiting list by 2030. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PANCREAS -- Transplantation
KW - KIDNEY transplants
KW - HOSPITALS -- Waiting lists
KW - DONATION of organs, tissues, etc.
KW - UNITED States
KW - 58 DSA Challenge
KW - 7000 Kidney Challenge
KW - Deceased donor kidneys
KW - donation service areas
KW - expanded criteria donors
KW - kidney transplantation
KW - living donor transplantation
KW - OPTN
KW - Organ Donation Breakthrough Collaborative
KW - organ procurement organization
KW - Organ Transplantation Breakthrough Collaborative
KW - pancreas transplantation
KW - SRTR
KW - survival
KW - UNITED States. Health Resources & Services Administration
N1 - Accession Number: 31228672; Leichtman, A. B. 1; Email Address: aleicht@umich.edu Cohen, D. 2 Keith, D. 3 O'Connor, K. 4 Goldstein, M. 5 McBride, V. 6 Gould, C. J. 7 Christensen, L. L. 8 Ashby, V. B. 1; Affiliation: 1: Scientific Registry of Transplant Recipients, University of Michigan, Ann Arbor, MI 2: Columbia Presbyterian Medical Center, New York, NY 3: McGill University Health Center, Montreal, Quebec, Canada 4: New England Organ Bank, Newton, MA 5: Weill-Cornell Medical College, New York, NY 6: Department of Health and Human Services, Health Resources and Services Administration, Rockville, MD 7: United Network for Organ Sharing, Richmond, VA 8: Scientific Registry of Transplant Recipients, Arbor Research Collaborative for Health, Ann Arbor, MI; Source Info: Apr2008, Vol. 8 Issue 4p2, p946; Subject Term: PANCREAS -- Transplantation; Subject Term: KIDNEY transplants; Subject Term: HOSPITALS -- Waiting lists; Subject Term: DONATION of organs, tissues, etc.; Subject Term: UNITED States; Author-Supplied Keyword: 58 DSA Challenge; Author-Supplied Keyword: 7000 Kidney Challenge; Author-Supplied Keyword: Deceased donor kidneys; Author-Supplied Keyword: donation service areas; Author-Supplied Keyword: expanded criteria donors; Author-Supplied Keyword: kidney transplantation; Author-Supplied Keyword: living donor transplantation; Author-Supplied Keyword: OPTN; Author-Supplied Keyword: Organ Donation Breakthrough Collaborative; Author-Supplied Keyword: organ procurement organization; Author-Supplied Keyword: Organ Transplantation Breakthrough Collaborative; Author-Supplied Keyword: pancreas transplantation; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: survival; Company/Entity: UNITED States. Health Resources & Services Administration; Number of Pages: 12p; Illustrations: 4 Charts, 20 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2008.02173.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31228672&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Merion, R. M.
AU - Barnes, A. D.
AU - Lin, M.
AU - Ashby, V. B.
AU - McBride, V.
AU - Ortiz-Rios, E.
AU - Welch, J. C.
AU - Levine, G. N.
AU - Port, F. K.
AU - Burdick, J.
T1 - Transplants in Foreign Countries Among Patients Removed from the US Transplant Waiting List.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2008/04/15/
VL - 8
IS - 4p2
M3 - Article
SP - 988
EP - 996
PB - Wiley-Blackwell
SN - 16006135
AB - Transplant tourism, where patients travel to foreign countries specifically to receive a transplant, is poorly characterized. This study examined national data to determine the minimum scope of this practice. US national waiting list removal data were analyzed. Waiting list removals for transplant without a corresponding US transplant in the database were reviewed via a data validation query to transplant centers to identify foreign transplants. Additionally, waiting list removal records with text field entries indicating a transplant abroad were identified. We identified 373 foreign transplants (173 directly noted; 200 from data validation); most (89.3%) were kidney transplants. Between 2001 and 2006, the annual number of waiting list removals for transplant abroad increased. Male sex, Asian race, resident and nonresident alien status and college education were significantly and independently associated with foreign transplant. Recipients from 34 states, plus the District of Columbia, received foreign transplants in 35 countries, led by China, the Philippines and India. Transplants in foreign countries among waitlisted candidates in the US are increasingly performed. The data reported here represent the minimum number of cases and the full extent of this practice cannot be determined using existing data. Additional reporting requirements are needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - MEDICAL tourism
KW - DATABASES
KW - HOSPITALS -- Waiting lists
KW - UNITED States
KW - foreign transplants
KW - transplant tourism
N1 - Accession Number: 31228669; Merion, R. M. 1,2; Email Address: merionb@umich.edu Barnes, A. D. 2,3 Lin, M. 4 Ashby, V. B. 2,5 McBride, V. 4 Ortiz-Rios, E. 4 Welch, J. C. 2,3 Levine, G. N. 2,3 Port, F. K. 2,3 Burdick, J. 4; Affiliation: 1: Department of Surgery, University of Michigan, Ann Arbor, MI 2: Scientific Registry of Transplant Recipients, Ann Arbor, MI 3: Arbor Research Collaborative for Health, Ann Arbor, MI 4: Division of Transplantation, Health Resources and Services Administration, US Department of Health and Human Services, Bethesda, MD 5: University of Michigan, Ann Arbor, MI; Source Info: Apr2008, Vol. 8 Issue 4p2, p988; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: MEDICAL tourism; Subject Term: DATABASES; Subject Term: HOSPITALS -- Waiting lists; Subject Term: UNITED States; Author-Supplied Keyword: foreign transplants; Author-Supplied Keyword: transplant tourism; Number of Pages: 9p; Illustrations: 7 Charts, 1 Map; Document Type: Article
L3 - 10.1111/j.1600-6143.2008.02176.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31228669&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dickinson, D. M.
AU - Arrington, C. J.
AU - Fant, G.
AU - Levine, G. N.
AU - Schaubel, D. E.
AU - Pruett, T. L.
AU - Roberts, M. S.
AU - Wolfe, R. A.
T1 - SRTR Program-Specific Reports on Outcomes: A Guide for the New Reader.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2008/04/15/
VL - 8
IS - 4p2
M3 - Article
SP - 1012
EP - 1026
PB - Wiley-Blackwell
SN - 16006135
AB - Differences in outcomes indeed exist among transplant programs and organ procurement organizations (OPO). A growing set of tools are available from the Scientific Registry of Transplant Recipients (SRTR) to measure and assess these outcomes in the different phases of the transplant process. These tools are not intended to compare two individual programs, rather to help identify programs whose practices may need further scrutiny, to be either avoided, corrected or emulated. To understand which differences in outcomes might be due to underlying differences in populations served and which might be due to differences in treatment, it is important to compare outcomes to ‘risk-adjusted’ expected values. Further, it is important to recognize and assess the role that random chance may play in these outcomes by considering the p-value or confidence interval of each estimate. We present the reader with a basic explanation of these tools and their interpretation in the context of reading the SRTR Program-Specific Reports. We describe the intended audience of these reports, including patients, monitoring and process improvement bodies, payers and others such as the media. Use of these statistics in a way that reflects a basic understanding of these concepts and their limitations is beneficial for all audiences. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROCUREMENT of organs, tissues, etc.
KW - TRANSPLANTATION of organs, tissues, etc.
KW - OUTCOME assessment (Medical care)
KW - CONFIDENCE intervals
KW - EVALUATION
KW - Program-specific
KW - risk-adjustment
KW - SRTR
KW - survival
KW - transplant outcomes
N1 - Accession Number: 31228667; Dickinson, D. M. 1; Email Address: david.dickinson@ArborResearch.org Arrington, C. J. 1 Fant, G. 2 Levine, G. N. 1 Schaubel, D. E. 3 Pruett, T. L. 4 Roberts, M. S. 5 Wolfe, R. A. 1; Affiliation: 1: Scientific Registry of Transplant Recipients, Arbor Research Collaborative for Health, Ann Arbor, MI 2: Health Resources and Services Administration, Rockville, MD 3: Scientific Registry of Transplant Recipients/University of Michigan, Ann Arbor, MI 4: University of Virginia, Division of Transplantation, Charlottesville, VA 5: University of Pittsburgh School of Medicine, Pittsburgh, PA; Source Info: Apr2008, Vol. 8 Issue 4p2, p1012; Subject Term: PROCUREMENT of organs, tissues, etc.; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: OUTCOME assessment (Medical care); Subject Term: CONFIDENCE intervals; Subject Term: EVALUATION; Author-Supplied Keyword: Program-specific; Author-Supplied Keyword: risk-adjustment; Author-Supplied Keyword: SRTR; Author-Supplied Keyword: survival; Author-Supplied Keyword: transplant outcomes; Number of Pages: 15p; Illustrations: 1 Diagram, 7 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2008.02178.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31228667&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Werber, Dirk
AU - Mason, Brendan W.
AU - Evans, Meirion R.
AU - Salmon, Roland L.
T1 - Preventing Household Transmission of Shiga Toxin—Producing Escherichia coli O157 Infection: Promptly Separating Siblings Might Be the Key.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/04/15/
VL - 46
IS - 8
M3 - Article
SP - 1189
EP - 1196
SN - 10584838
AB - Background. Preventing household transmission of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection is important because of the ease of interpersonal transmission and the potential disease severity. Methods. We conducted a retrospective cohort study of households associated with an outbreak of STEC O157 infection in South Wales, United Kingdom, in autumn 2005. We investigated whether characteristics of the primary case patient or the household were predictors for secondary household transmission of STEC O157 infection. Furthermore, we estimated the proportion of cases that might be prevented by isolation (e.g., hospitalization) of the primary case patient immediately after the microbiological diagnosis and the number of patients with STEC O157 who would need to be isolated to prevent 1 case of hemolytic uremic syndrome. Based on dates of symptom onset, case patients in households were classified as having primary, coprimary, or secondary infection. Secondary cases were considered to be preventable if the secondary case patient's symptoms started >1 incubation period (4 days) after the date of microbiological diagnosis of the primary case. Results. Eighty-nine (91%) of 98 eligible households were enrolled. Among 20 households (22%), 25 secondary cases were ascertained. Thirteen secondary cases (56%) occurred in siblings of the primary case patients; hemolytic uremic syndrome developed in 4 of these siblings. Presence of a sibling (risk ratio, 3.8; 95% confidence interval, 0.99-14.6) and young age (<5 years) of the primary case patient (risk ratio, 2.03; 95% confidence interval, 0.99- 41.6) were independent predictors for households in which secondary cases occurred. Of the 15 secondary cases for which complete information was available, 7 (46%) might have been prevented. When restricting isolation to primary case patients who were aged <10 years and who had a sibling, we estimated the number of patients who would need to be isolated to prevent 1 case of hemolytic uremic syndrome to be 47 patients (95% confidence interval, 16-78 patients). Conclusions. Promptly separating pediatric patients with STEC O157 infection from their young siblings should be considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enterobacteriaceae
KW - Communicable diseases -- Prevention
KW - Medical sciences
KW - Medical research
KW - Diagnostic microbiology
KW - Cohort analysis
KW - Escherichia coli O157:H7
KW - Isolation (Hospital care)
KW - Great Britain
N1 - Accession Number: 31789468; Werber, Dirk 1,2; Email Address: werberd@rki.de; Mason, Brendan W. 1; Evans, Meirion R. 1; Salmon, Roland L. 1; Affiliations: 1: Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, United Kingdom; 2: European Programme for Intervention Epidemiology Training; Issue Info: 4/15/2008, Vol. 46 Issue 8, p1189; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Communicable diseases -- Prevention; Subject Term: Medical sciences; Subject Term: Medical research; Subject Term: Diagnostic microbiology; Subject Term: Cohort analysis; Subject Term: Escherichia coli O157:H7; Subject Term: Isolation (Hospital care); Subject: Great Britain; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1086/587670
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31789468&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hoffmann, Maria
AU - Keys, Christine E.
AU - Song, Kwang-Young
AU - Brown, Eric W.
AU - Fry, Frederick S.
AU - Whittaker, Paul
T1 - Evaluation of multiple strains of Enterobacter sakazakii using fatty acid profiles
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008/04/15/
VL - 107
IS - 4
M3 - Article
SP - 1623
EP - 1628
SN - 03088146
AB - Abstract: Fatty acid profiles are useful for identifying Gram-negative Enterobacter sakazakii strains within the family Enterobacteriaceae. The majority of cases of E. sakazakii infection have involved sepsis, meningitis, or enteritis, especially in neonates and infants. Gas chromatography with flame ionization detection (GC-FID) was utilized for the analysis of cellular fatty acid methyl esters (FAMEs). Thirty E. sakazakii strains isolated from food and environmental sources were cultured for 24h on brain heart infusion (BHI) agar on three different days at 37°C. Whole cell FAMEs were obtained by saponification, methylation and extraction into hexane:methyl tert-butyl ether. The day to day variations for the 30 E. sakazakii strains for each fatty acid were determined. Gram-negative bacteria commonly contain combinations of straight-chain, unsaturated, hydroxyl, and cyclo fatty acids. Major fatty acids of E. sakazakii strains evaluated in this study were straight chain 12:0, 14:0, 16:0 and unsaturated 16:1, 18:1, and 17:0 ωcyclo 7–8. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by this rapid GC-FID method is highly reproducible and provides a sensitive procedure for identification of this organism. The fatty acid profile assay could be used to rapidly screen infant formula samples for E. sakazakii and reduce the time required for the current assay by up to 5days. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FATTY acids
KW - CARBOXYLIC acids
KW - ACETIC acid
KW - BUTYRIC acid
KW - Enterobacter sakazakii
KW - Fatty acids
KW - Gas chromatography
N1 - Accession Number: 27758155; Hoffmann, Maria 1 Keys, Christine E. 1 Song, Kwang-Young 1 Brown, Eric W. 1 Fry, Frederick S. 1 Whittaker, Paul; Email Address: paul.whittaker@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Apr2008, Vol. 107 Issue 4, p1623; Subject Term: FATTY acids; Subject Term: CARBOXYLIC acids; Subject Term: ACETIC acid; Subject Term: BUTYRIC acid; Author-Supplied Keyword: Enterobacter sakazakii; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Gas chromatography; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.foodchem.2007.10.032
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27758155&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - De Jager, Lowri S.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Comparison of headspace-SPME-GC–MS and LC–MS for the detection and quantification of coumarin, vanillin, and ethyl vanillin in vanilla extract products
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2008/04/15/
VL - 107
IS - 4
M3 - Article
SP - 1701
EP - 1709
SN - 03088146
AB - Abstract: A headspace-solid phase micro-extraction (HS-SPME) GC–MS method has been developed for the determination of coumarin, vanillin and ethyl vanillin in vanilla products. Limits of detection ranged from 1.33 to 13.2ngmL−1. Accuracy and precision data for the method were measured and compared to those obtained using LC-ESI-MS. A survey of 24 commercially available vanilla products was completed using both techniques. No coumarin was detected in any of the samples. Examination of the GC–MS chromatograms revealed the presence of 18 other flavor related compounds in the samples. The method validation and sample analysis data using HS-SPME-GC–MS were comparable to those obtained using the LC–MS method. Because the two methods are conceptually different from one another, both methods would not be subject to the same interferences. This would allow them to be used as confirmatory methods for each other. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTICOAGULANTS (Medicine)
KW - HEMATOLOGIC agents
KW - BLOOD coagulation
KW - HEPARIN
KW - Coumarin
KW - GC–MS
KW - Headspace
KW - HS-SPME
KW - LC–MS
KW - Vanilla
N1 - Accession Number: 27758166; De Jager, Lowri S.; Email Address: lowri.dejager@fda.hhs.gov Perfetti, Gracia A. 1 Diachenko, Gregory W. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20785, United States; Source Info: Apr2008, Vol. 107 Issue 4, p1701; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: HEMATOLOGIC agents; Subject Term: BLOOD coagulation; Subject Term: HEPARIN; Author-Supplied Keyword: Coumarin; Author-Supplied Keyword: GC–MS; Author-Supplied Keyword: Headspace; Author-Supplied Keyword: HS-SPME; Author-Supplied Keyword: LC–MS; Author-Supplied Keyword: Vanilla; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.foodchem.2007.09.070
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=27758166&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - González-Escalona, Narjol
AU - Martinez-Urtaza, Jaime
AU - Romero, Jaime
AU - Espejo, Romilio T.
AU - Jaykus, Lee-Ann
AU - DePaola, Angelo
T1 - Determination of Molecular Phylogenetics of Vibrio parahaemolyticus Strains by Multilocus Sequence Typing.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008/04/15/
VL - 190
IS - 8
M3 - Article
SP - 17
EP - 17
SN - 00219193
AB - Vibrio parahaemolyticus is an important human pathogen whose transmission is associated with the consumption of contaminated seafood. There is a growing public health concern due to the emergence of a pandemic strain causing severe outbreaks worldwide. Many questions remain unanswered regarding the evolution and population structure of V. parahaemolyticus. In this work, we describe a multilocus sequence typing (MLST) scheme for V. parahaemolyticus based on the internal fragment sequences of seven housekeeping genes. This MLST scheme was applied to 100 V. parahaemolyticus strains isolated from geographically diverse clinical (n = 37) and environmental (n = 63) sources. The sequences obtained from this work were deposited and are available in a public database (http://pubmlst.org/vparahaemolyticus). Sixty-two unique sequence types were identified, and most (50) were represented by a single isolate, suggesting a high level of genetic diversity. Three major clonal complexes were identified by eBURST analysis. Separate clonal complexes were observed for V. parahaemolyticus isolates originating from the Pacific and Gulf coasts of the United States, while a third clonal complex consisted of strains belonging to the pandemic clonal complex with worldwide distribution. The data reported in this study indicate that V. parahaemolyticus is genetically diverse with a semiclonal population structure and an epidemic structure similar to that of Vibrio cholerae. Genetic diversity in V. parahaemolyticus appears to be driven primarily by frequent recombination rather than mutation, with recombination ratios estimated at 2.5:1 and 8.8:1 by allele and site, respectively. Application of this MLST scheme to more V. parahaemolyticus strains and by different laboratories will facilitate production of a global picture of the epidemiology and evolution of this pathogen. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYLOGENY -- Molecular aspects
KW - MOLECULAR biology
KW - VIBRIO parahaemolyticus
KW - VIBRIO
KW - VIBRIO cholerae
KW - VIBRIO costicola
KW - VIBRIO fischeri
N1 - Accession Number: 31692878; González-Escalona, Narjol 1,2; Email Address: narjol@gmail.com Martinez-Urtaza, Jaime 3 Romero, Jaime 4 Espejo, Romilio T. 4 Jaykus, Lee-Ann 1 DePaola, Angelo 5; Affiliation: 1: Department of Food Science, North Carolina State University, Raleigh, North Carolina 2: Center for Food and Applied Nutrition, Food and Drug Administration, College Park, Maryland 3: Instituto de Acuicultura, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Spain 4: Laboratorio de Biotecnología, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile 5: Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama; Source Info: Apr2008, Vol. 190 Issue 8, p17; Subject Term: PHYLOGENY -- Molecular aspects; Subject Term: MOLECULAR biology; Subject Term: VIBRIO parahaemolyticus; Subject Term: VIBRIO; Subject Term: VIBRIO cholerae; Subject Term: VIBRIO costicola; Subject Term: VIBRIO fischeri; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.01808-07
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31692878&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jihee Lee Kang
AU - Changsuk Moon
AU - Hui Su Lee
AU - Hae Won Lee
AU - Eun-Mi Park
AU - Hee Sun Kim
AU - Castranova, Vincent
T1 - Comparison of the Biological Activity Between Ultrafine and Fine Titanium Dioxide Particles in RAW 264.7 Cells Associated with Oxidative Stress.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/04/15/
VL - 71
IS - 8
M3 - Article
SP - 478
EP - 485
SN - 15287394
AB - Ultrafine or fine titanium dioxide (TiO2) particles are widely used in the production of white pigments, for sunscreens, and in cleanup techniques. However, currently knowledge is deficient concerning cellular responses to these particles. The study evaluated and compared the biological activity of ultrafine and fine TiO2 particles in RAW 264.7 macrophages according to an oxidative stress paradigm. In vitro exposure of macrophages to ultrafine or fine TiO2 in the range of 0.5-200 μg/ml did not significantly alter cell viability. However, ultrafine TiO2 enhanced intracellular generation of reactive oxygen species (ROS) to a greater extent than fine TiO2 at each exposure concentration. Ultrafine TiO2 induced ERK1/2 activation in a concentration-dependent manner, while the fine TiO2-induced changes were minimal. Phosphorylation of ERK1/2 occurred following 10 min exposure to higher concentrations of ultrafine TiO2 (≥25 μg/ml). Similarly, ultrafine TiO2 exposure significantly enhanced tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 secretion in a concentration-dependent manner, and its potency was higher than fine TiO2. These findings suggest that when exposure concentration is based upon equivalent mass, ultrafine TiO2 exerts greater biological activity as measured by ROS generation, ERK 1/2 activation, and proinflammatory mediator secretion in RAW 264.7 macrophages than fine TiO2. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TITANIUM dioxide
KW - OXIDATIVE stress
KW - MACROPHAGES
KW - PHOSPHORYLATION
KW - NECROSIS
KW - OXIDATION-reduction reaction
N1 - Accession Number: 31255775; Jihee Lee Kang 1; Email Address: jihee@ewha.ac.kr Changsuk Moon 1 Hui Su Lee 1 Hae Won Lee 1 Eun-Mi Park 2 Hee Sun Kim 3 Castranova, Vincent 4; Affiliation: 1: Departments of Physiology, Seoul, South Korea 2: Pharmacology, Seoul, South Korea 3: Neuroscience, Division of Cell Biology, Ewha Medical Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea 4: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Apr2008, Vol. 71 Issue 8, p478; Subject Term: TITANIUM dioxide; Subject Term: OXIDATIVE stress; Subject Term: MACROPHAGES; Subject Term: PHOSPHORYLATION; Subject Term: NECROSIS; Subject Term: OXIDATION-reduction reaction; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390801906675
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31255775&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Battelli, Lori A.
AU - Ghanem, Mohamed M.
AU - Kashon, Michael L.
AU - Barger, Mark
AU - Ma, Jane Y. C.
AU - Simoskevitz, Ricki L.
AU - Miles, Philip R.
AU - Hubbs, Ann F.
T1 - Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/04/15/
VL - 71
IS - 8
M3 - Article
SP - 521
EP - 532
SN - 15287394
AB - Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. PAHs also stimulate their own metabolism by inducing CYP1A1. Recent studies suggest that respirable coal dust exposure inhibits induction of pulmonary CYP1A1 using the model PAH β-naphthoflavone. The effect of the occupational particulate respirable crystalline silica was investigated on PAH-dependent pulmonary CYP1A1 induction. Male Sprague-Dawley rats were exposed to intratracheal silica or vehicle and then intraperitoneal β-naphthoflavone, a CYP1A1 inducer, and/or phenobarbital, an inducer of hepatic CYP2B1, or vehicle. β-Naphthoflavone induced pulmonary CYP1A1, but silica attenuated this β-naphthoflavone-induced CYP1A1 activity and also suppressed the activity of CYP2B1, the major constituitive CYP in rat lung. The magnitude of CYP activity suppression was similar regardless of silica exposure dose within a range of 5 to 20 mg/rat. Phenobarbital and β-naphthoflavone had no effect on pulmonary CYP2B1 activity. Both enzymatic immunohistochemistry and immunofluorescent staining for CYP1A1 indicated that sites of CYP1A1 induction were nonciliated airway epithelial cells, endothelial cells, and the alveolar septum. Using immunofluorescent colocalization of CYP1A1 with cytokeratin 8, a marker of alveolar type II cells, the proximal alveolar region was the site of both increased alveolar type II cells and decreased proportional CYP1A1 expression in alveolar type II cells. Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROMES
KW - POLYCYCLIC aromatic hydrocarbons
KW - CARDIOPULMONARY system
KW - CARCINOGENS
KW - METABOLISM
KW - EPITHELIAL cells
KW - SEPTUM (Brain)
KW - EMPLOYEES
KW - IMMUNOHISTOCHEMISTRY
N1 - Accession Number: 31255769; Battelli, Lori A. 1; Email Address: LBattelli@cdc.gov Ghanem, Mohamed M. 1 Kashon, Michael L. 1 Barger, Mark 1 Ma, Jane Y. C. 1 Simoskevitz, Ricki L. 1 Miles, Philip R. 1 Hubbs, Ann F. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Source Info: Apr2008, Vol. 71 Issue 8, p521; Subject Term: CYTOCHROMES; Subject Term: POLYCYCLIC aromatic hydrocarbons; Subject Term: CARDIOPULMONARY system; Subject Term: CARCINOGENS; Subject Term: METABOLISM; Subject Term: EPITHELIAL cells; Subject Term: SEPTUM (Brain); Subject Term: EMPLOYEES; Subject Term: IMMUNOHISTOCHEMISTRY; Number of Pages: 12p; Illustrations: 7 Color Photographs, 1 Black and White Photograph, 8 Graphs; Document Type: Article
L3 - 10.1080/15287390801907483
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31255769&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olivero, Ofelia A.
AU - Ming, Jessica M.
AU - Das, Shreyasi
AU - Vazquez, Irma L.
AU - Richardson, Diana L.
AU - Weston, Ainsley
AU - Poirier, Miriam C.
T1 - Human inter-individual variability in metabolism and genotoxic response to zidovudine
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/04/15/
VL - 228
IS - 2
M3 - Article
SP - 158
EP - 164
SN - 0041008X
AB - Abstract: A mainstay of the antiretroviral drugs used for therapy of HIV-1, zidovudine (AZT) is genotoxic and becomes incorporated into DNA. Here we explored host inter-individual variability in AZT-DNA incorporation, by AZT radioimmunoassay (RIA), using 19 different strains of normal human mammary epithelial cells (NHMECs) exposed for 24 h to 200 μM AZT. Twelve of the 19 NHMEC strains showed detectable AZT-DNA incorporation levels (16 to 259 molecules of AZT/106 nucleotides), while 7 NHMEC strains did not show detectable AZT-DNA incorporation. In order to explore the basis for this variability, we compared the 2 NHMEC strains that showed the highest levels of AZT-DNA incorporation (H1 and H2) with 2 strains showing no detectable AZT-DNA incorporation (L1 and L2). All 4 strains had similar (≥80%) cell survival, low levels of accumulation of cells in S-phase, and no relevant differences in response to the direct-acting mutagen bleomycin (BLM). Finally, when levels of thymidine kinase 1 (TK1), the first enzyme in the pathway for incorporation of AZT into DNA, were determined by Western blot analysis in all 19 NHMEC strains at 24 h of AZT exposure, higher TK1 protein levels were found in the 12 strains showing AZT-DNA incorporation, compared to the 7 showing no incorporation (p =0.0005, Mann–Whitney test). Furthermore, strains L1 and L2, which did not show AZT-DNA incorporation at 24 h, did have measurable incorporation by 48 and 72 h. These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLISM
KW - GENETIC toxicology
KW - AZT (Drug)
KW - RADIOIMMUNOASSAY
KW - AZT
KW - Nucleoside analogs
KW - Thymidine kinase 1
N1 - Accession Number: 31684563; Olivero, Ofelia A. 1; Email Address: oliveroo@exchange.nih.gov Ming, Jessica M. 1 Das, Shreyasi 1 Vazquez, Irma L. 1 Richardson, Diana L. 2 Weston, Ainsley 2 Poirier, Miriam C. 1; Affiliation: 1: Carcinogen–DNA Interactions Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA 2: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505-2888, USA; Source Info: Apr2008, Vol. 228 Issue 2, p158; Subject Term: METABOLISM; Subject Term: GENETIC toxicology; Subject Term: AZT (Drug); Subject Term: RADIOIMMUNOASSAY; Author-Supplied Keyword: AZT; Author-Supplied Keyword: Nucleoside analogs; Author-Supplied Keyword: Thymidine kinase 1; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.taap.2007.12.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31684563&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lo, Chia-Yun
AU - Wu, Zhengqi
AU - Misplon, Julia A.
AU - Price, Graeme E.
AU - Pappas, Claudia
AU - Kong, Wing-Pui
AU - Tumpey, Terrence M.
AU - Epstein, Suzanne L.
T1 - Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: Cold-adapted vaccine versus DNA prime-adenovirus boost strategies
JO - Vaccine
JF - Vaccine
Y1 - 2008/04/16/
VL - 26
IS - 17
M3 - Article
SP - 2062
EP - 2072
SN - 0264410X
AB - Summary: Influenza epidemics or pandemics can arise for which strain- or subtype-matched vaccines are unavailable. Heterosubtypic immunity (Het-I) targeting conserved influenza A antigens could reduce morbidity and mortality during preparation of matched vaccines. Various vaccines inducing Het-I in animals have been studied separately using different viruses and conditions, but effectiveness for inducing Het-I has not been directly compared. The present studies compared immunization with cold-adapted (ca) viruses to DNA prime-recombinant adenovirus (rAd) boost vaccination to conserved antigens nucleoprotein (NP), matrix-2 (M2), or A/NP+M2. Both ca and DNA-rAd vaccinations induced antibody and T cell responses, and protected against lethal H1N1 challenge. Only A/NP+M2 DNA-rAd protected against challenge with highly pathogenic A/Vietnam/1203/2004 (H5N1); ca vaccine did not. Existing ca vaccines may provide some Het-I, but experimental vaccination focusing on conserved antigens was more effective in this model for protection against a divergent, highly pathogenic virus. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunization
KW - Vaccination
KW - Influenza
KW - Preventive medicine
KW - Heterosubtypic immunity
KW - Pandemic
N1 - Accession Number: 31679743; Lo, Chia-Yun 1; Wu, Zhengqi 1; Misplon, Julia A. 1; Price, Graeme E. 1; Pappas, Claudia 2; Kong, Wing-Pui 3; Tumpey, Terrence M. 2; Epstein, Suzanne L. 1; Email Address: suzanne.epstein@fda.hhs.gov; Affiliations: 1: Division of Cellular and Gene Therapies, Office of Cellular Tissue and Gene Therapies, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), 1401 Rockville Pike, HFM-730, Rockville, MD 20852-1448, USA; 2: Influenza Division, Mailstop G-16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA; 3: Vaccine Research Center, National Institute for Allergy and Infectious Diseases, Room 4504, National Institutes of Health, Bethesda, MD 20892, USA; Issue Info: Apr2008, Vol. 26 Issue 17, p2062; Thesaurus Term: Immunization; Thesaurus Term: Vaccination; Thesaurus Term: Influenza; Subject Term: Preventive medicine; Author-Supplied Keyword: Heterosubtypic immunity; Author-Supplied Keyword: Pandemic; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.02.047
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31679743&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Atrasheuskaya, A.V.
AU - Kulak, M.V.
AU - Neverov, A.A.
AU - Rubin, S.
AU - Ignatyev, G.M.
T1 - Measles cases in highly vaccinated population of Novosibirsk, Russia, 2000–2005
JO - Vaccine
JF - Vaccine
Y1 - 2008/04/16/
VL - 26
IS - 17
M3 - Article
SP - 2111
EP - 2118
SN - 0264410X
AB - Summary: While the proportion of measles cases in vaccinees is expected to increase as vaccine coverage increases, such cases must be carefully investigated. The present study was conducted to examine possible contributions to vaccine failures (VFs) and to genetically characterize measles virus (MV) strains circulating in Novosibirsk, Russia during 2000–2005. Totally, 27 adult measles patients admitted to a regional hospital were prospectively enrolled in our study. Genetic characterization of the MV strains revealed circulation of genotypes A, D4 and D6 between 2000 and 2003 years; a genotype D6 MV was associated with the 2005 measles outbreak. Based on IgG avidity testing, half of the vaccinated patients demonstrated evidence of secondary vaccine failure (SVF). Patients, representing both levels of vaccine failure in our study were characterized by the lack of protective titers of neutralizing antibodies against circulating MVs, despite high IgG levels in many cases and high IgG avidity in SVF cases. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - RESEARCH
KW - Measles
KW - Patients
KW - Immunoglobulins
KW - Genotyping
KW - Measles
KW - Neutralizing titers
KW - Russia
KW - Vaccine failure
N1 - Accession Number: 31679750; Atrasheuskaya, A.V. 1; Email Address: marburgman3@infonet.by; Kulak, M.V. 1; Neverov, A.A. 1; Rubin, S. 2; Ignatyev, G.M. 1; Affiliations: 1: State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Russia; 2: Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Issue Info: Apr2008, Vol. 26 Issue 17, p2111; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Thesaurus Term: RESEARCH; Subject Term: Measles; Subject Term: Patients; Subject Term: Immunoglobulins; Author-Supplied Keyword: Genotyping; Author-Supplied Keyword: Measles; Author-Supplied Keyword: Neutralizing titers; Author-Supplied Keyword: Russia; Author-Supplied Keyword: Vaccine failure; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.02.028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31679750&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Ehrenfeld, Ellie
AU - Glass, Roger I.
AU - Agol, Vadim I.
AU - Chumakov, Konstantin
AU - Dowdle, Walter
AU - John, T. Jacob
AU - Katz, Samuel L.
AU - Miller, Mark
AU - Breman, Joel G.
AU - Modlin, John
AU - Wright, Peter
T1 - Immunisation against poliomyelitis: moving forward.
JO - Lancet
JF - Lancet
Y1 - 2008/04/19/
VL - 371
IS - 9621
M3 - Editorial
SP - 1385
EP - 1387
SN - 00995355
AB - The authors reflect on the use of immunization in the prevention of and eradication of poliomyelitis. The authors suggest that the reason poliomyelitis has not been eradicated is because several oral poliomyelitis vaccines have been proven to be ineffective. They argue that new vaccine strategies could be critical in the eradication of the disease.
KW - ENTEROVIRUS diseases
KW - IMMUNIZATION
KW - POLIO -- Prevention
KW - PREVENTIVE medicine
KW - WORLD health
N1 - Accession Number: 31761968; Ehrenfeld, Ellie 1 Glass, Roger I. 2 Agol, Vadim I. 3 Chumakov, Konstantin 4 Dowdle, Walter 5 John, T. Jacob 6 Katz, Samuel L. 7 Miller, Mark 2 Breman, Joel G. 2 Modlin, John 8 Wright, Peter 8,9; Affiliation: 1: National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 2: Fogarty International Center, National Institutes of Health, Bethesda, MD, USA 3: Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia 4: Food and Drug Administration, PHHS, Rockville, MD, USA 5: Task Force Child Survival and Development, Atlanta, GA, USA 6: Christian Medical College, Vellore, India 7: Duke University Medical School, Durham, NC, USA 8: Dartmouth Medical School, Hannover, NH, USA 9: Vanderbilt Medical Center, Nashville, TN, USA; Source Info: 4/19/2008, Vol. 371 Issue 9621, p1385; Subject Term: ENTEROVIRUS diseases; Subject Term: IMMUNIZATION; Subject Term: POLIO -- Prevention; Subject Term: PREVENTIVE medicine; Subject Term: WORLD health; Number of Pages: 3p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Koren, Eugen
AU - Smith, Holly W.
AU - Shores, Elizabeth
AU - Shankar, Gopi
AU - Finco-Kent, Deborah
AU - Rup, Bonita
AU - Barrett, Yu-Chen
AU - Devanarayan, Viswanath
AU - Gorovits, Boris
AU - Gupta, Shalini
AU - Parish, Thomas
AU - Quarmby, Valerie
AU - Moxness, Michael
AU - Swanson, Steven J.
AU - Taniguchi, Gary
AU - Zuckerman, Linda A.
AU - Stebbins, Christopher C.
AU - Mire-Sluis, Anthony
T1 - Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2008/04/20/
VL - 333
IS - 1/2
M3 - Article
SP - 1
EP - 9
SN - 00221759
AB - Abstract: The appropriate evaluation of the immunogenicity of biopharmaceuticals is of major importance for their successful development and licensure. Antibodies elicited by these products in many cases cause no detectable clinical effects in humans. However, antibodies to some therapeutic proteins have been shown to cause a variety of clinical consequences ranging from relatively mild to serious adverse events. In addition, antibodies can affect drug efficacy. In non-clinical studies, anti-drug antibodies (ADA) can complicate interpretation of the toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) data. Therefore, it is important to develop testing strategies that provide valid assessments of antibody responses in both non-clinical and clinical studies. This document provides recommendations for antibody testing strategies stemming from the experience of contributing authors. The recommendations are intended to foster a more unified approach to antibody testing across the biopharmaceutical industry. The strategies proposed are also expected to contribute to better understanding of antibody responses and to further advance immunogenicity evaluation. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME-linked immunosorbent assay
KW - IMMUNOENZYME technique
KW - SOLID-phase analysis
KW - GROWTH factors
KW - CYTOKINES
KW - anti-drug antibodies ( ADA )
KW - enzyme-linked immunosorbent assay ( ELISA )
KW - erythropoietin ( Epo )
KW - glial cell derived nerve growth factor ( GDNF )
KW - Good laboratory practice ( GLP )
KW - Immunogenicity testing
KW - immunoglobulin ( Ig )
KW - megakaryocyte growth and differentiation factor ( MGDF )
KW - Organization for Economic and Development Co-Operation ( OECD )
KW - pharmacodynamic ( PD )
KW - pharmacokinetic ( PK )
KW - pure red cell aplasia ( PRCA )
KW - recombinant human ( r-Hu )
KW - Risk assessment
KW - Therapeutic proteins
KW - thrombopoietin. ( Tpo )
KW - tumor necrosis factor ( TNF )
N1 - Accession Number: 31562749; Koren, Eugen 1; Email Address: eugen.koren@av.abbott.com Smith, Holly W. 2 Shores, Elizabeth 3 Shankar, Gopi 4 Finco-Kent, Deborah 5 Rup, Bonita 6 Barrett, Yu-Chen 7 Devanarayan, Viswanath 8 Gorovits, Boris 9 Gupta, Shalini 10 Parish, Thomas 11 Quarmby, Valerie 12 Moxness, Michael 10 Swanson, Steven J. 10 Taniguchi, Gary 13 Zuckerman, Linda A. 14 Stebbins, Christopher C. 12 Mire-Sluis, Anthony 15; Affiliation: 1: Bioanalytical R&D, Abbott Vascular Inc., Santa Clara, CA 95054, USA 2: Investigative Toxicology, Eli Lilly and Company, Greenfield, IN 46140 USA 3: Office of Biotechnology Products, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 1 4: Clinical Pharmacology & Experimental Medicine, Centocor Research & Development Inc. Radnor, PA 19087, USA 5: Drug Safety Research and Development, Pfizer, Groton, CT 06340, USA 6: Bioanalytical R&D, Drug Safety and Metabolism, Wyeth Research, Andover MA 01810, USA 7: Clinical discovery, Bristol-Myers Squibb Company, Princeton, NJ 08543, USA 8: Merck & Co. Inc., Upper Gwynedd, PA 19087, USA 9: Drug Safety and Metabolism, Wyeth, Pearl River, NY 10965, USA 10: Clinical Immunology Department, Medical Sciences, Amgen Inc., Thousand Oaks, CA 91320, USA 11: Analytical Science Department, Procter & Gamble Pharmaceuticals, Norwich, NY 13815, USA 12: BioAnalytical Research & Development, Genentech, South San Francisco, CA 94080, USA 13: Analytical Sciences, PDL BioPharma Inc., Fremont CA 94555, USA 14: PreClinical Development Department, ZymoGenetics Inc. Seattle, WA 98102, USA 15: Global Product Quality and External Affairs, Amgen Inc., Longmont, CO 80503, USA; Source Info: Apr2008, Vol. 333 Issue 1/2, p1; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: IMMUNOENZYME technique; Subject Term: SOLID-phase analysis; Subject Term: GROWTH factors; Subject Term: CYTOKINES; Author-Supplied Keyword: anti-drug antibodies ( ADA ); Author-Supplied Keyword: enzyme-linked immunosorbent assay ( ELISA ); Author-Supplied Keyword: erythropoietin ( Epo ); Author-Supplied Keyword: glial cell derived nerve growth factor ( GDNF ); Author-Supplied Keyword: Good laboratory practice ( GLP ); Author-Supplied Keyword: Immunogenicity testing; Author-Supplied Keyword: immunoglobulin ( Ig ); Author-Supplied Keyword: megakaryocyte growth and differentiation factor ( MGDF ); Author-Supplied Keyword: Organization for Economic and Development Co-Operation ( OECD ); Author-Supplied Keyword: pharmacodynamic ( PD ); Author-Supplied Keyword: pharmacokinetic ( PK ); Author-Supplied Keyword: pure red cell aplasia ( PRCA ); Author-Supplied Keyword: recombinant human ( r-Hu ); Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Therapeutic proteins; Author-Supplied Keyword: thrombopoietin. ( Tpo ); Author-Supplied Keyword: tumor necrosis factor ( TNF ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jim.2008.01.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lim, Heon-Chang
AU - Lee, Soon-Tae
AU - Chu, Kon
AU - Joo, Kyung Min
AU - Kang, Lami
AU - Im, Woo-Seok
AU - Park, Joung-Eun
AU - Kim, Seung U.
AU - Kim, Manho
AU - Cha, Choong-Ik
T1 - Neuroprotective effect of neural stem cell-conditioned media in in vitro model of Huntington's disease
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2008/04/25/
VL - 435
IS - 3
M3 - Article
SP - 175
EP - 180
SN - 03043940
AB - Abstract: Although neural stem cell (NSC) transplantation has been investigated as a promising tool for reconstituting damaged brains, recent evidences suggest that NSCs may rescue the brain via paracrine effects rather than by direct cell replacements. In this study, we attempted to determine the neuroprotective effect of NSC-conditioned media (NSC-CM) in in vitro model of Huntington''s disease. Cerebral hybrid neurons (A1) were transfected with either wild-type huntingtin (18 CAG repeats) or mutant huntingtin (100 CAG repeats). At 24h after the transfection, immunocytochemical patterns of the huntingtin aggregations, as well as the level of N-terminal proteolytic cleavages of huntingtin were analyzed. Neuronal apoptosis was evaluated with flowcytometry after Annexin-V and propidium iodide (PI) staining. Cerebral hybrid neurons transfected with mutant huntingtin showed five aggregates patterns, including diffuse cytoplasmic, dispered vacuoles, perinuclear vacuoles, nuclear inclusions (NI), and cytoplasmic inclusions (CI). NSC-CM reduced the levels of nuclear and cytoplasmic inclusions. The transfection with mutant huntingtin increased the level of N-terminal cleavages, which was reduced by the NSC-CM treatment. In addition, NSC-CM reduced the Annexin-V+PI+ and Annexin-V+PI− neurons which were induced by the mutant huntingtin transfection. In summary, NSC-CM was neuroprotective in in vitro model of Huntington''s disease with modulating mutant huntingtin-induced cytotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAL stem cells -- Transplantation
KW - BRAIN
KW - HUNTINGTON'S chorea
KW - APOPTOSIS
KW - INCLUSION body myositis
KW - Conditioned media
KW - Huntingtin
KW - Huntington's disease
KW - Inclusion body
KW - Neural stem cells
KW - Neuroprotection
N1 - Accession Number: 31679920; Lim, Heon-Chang 1,2 Lee, Soon-Tae 2,3,4 Chu, Kon 2,3 Joo, Kyung Min 1 Kang, Lami 3 Im, Woo-Seok 3 Park, Joung-Eun 3 Kim, Seung U. 5,6 Kim, Manho 2,3; Email Address: kimmanho@snu.ac.kr Cha, Choong-Ik 1,2; Affiliation: 1: Department of Anatomay, College of Medicine, Seoul National University, Seoul, South Korea 2: Program in Neuroscience, SNUMRC, Seoul National University, Seoul, South Korea 3: Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea 4: Program in Public Health Service, Seoul National Hospital, Seoul, South Korea 5: Institute for Regenerative Medicine, Gachon Medical University, Inchon, South Korea 6: Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada; Source Info: Apr2008, Vol. 435 Issue 3, p175; Subject Term: NEURAL stem cells -- Transplantation; Subject Term: BRAIN; Subject Term: HUNTINGTON'S chorea; Subject Term: APOPTOSIS; Subject Term: INCLUSION body myositis; Author-Supplied Keyword: Conditioned media; Author-Supplied Keyword: Huntingtin; Author-Supplied Keyword: Huntington's disease; Author-Supplied Keyword: Inclusion body; Author-Supplied Keyword: Neural stem cells; Author-Supplied Keyword: Neuroprotection; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.neulet.2008.02.035
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sigurdson, Alice J.
AU - Ha, Mina
AU - Hauptmann, Michael
AU - Bhatti, Parveen
AU - Sram, Radim J.
AU - Beskid, Olena
AU - Tawn, E. Janet
AU - Whitehouse, Caroline A.
AU - Lindholm, Carita
AU - Nakano, Mimako
AU - Kodama, Yoshiaki
AU - Nakamura, Nori
AU - Vorobtsova, Irena
AU - Oestreicher, Ursula
AU - Stephan, Günther
AU - Yong, Lee C.
AU - Bauchinger, Manfred
AU - Schmid, Ernst
AU - Chung, Hai Won
AU - Darroudi, Firouz
T1 - International study of factors affecting human chromosome translocations
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2008/04/30/
VL - 652
IS - 2
M3 - Article
SP - 112
EP - 121
SN - 13835718
AB - Abstract: Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from 16 laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages versus a linear relationship (p <0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR)=1.19, 95% confidence interval (CI), 1.09–1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p <0.001). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cigarette smokers
KW - Persons
KW - Addicts
KW - Cigarettes
KW - Background frequency
KW - Chromosome translocations
KW - Controls
KW - Fluorescence in situ hybridization
N1 - Accession Number: 31925069; Sigurdson, Alice J. 1; Ha, Mina 1,2; Hauptmann, Michael 3,4; Bhatti, Parveen 1; Sram, Radim J. 5; Beskid, Olena 5; Tawn, E. Janet 6; Whitehouse, Caroline A. 7; Lindholm, Carita 8; Nakano, Mimako 9; Kodama, Yoshiaki 9; Nakamura, Nori 9; Vorobtsova, Irena 10; Oestreicher, Ursula 11; Stephan, Günther 11; Yong, Lee C. 12; Bauchinger, Manfred 13; Schmid, Ernst 13; Chung, Hai Won 14; Darroudi, Firouz 15; Affiliations: 1: Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA; 2: Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea; 3: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA; 4: Bioinformatics and Statistics, Netherlands Cancer Institute, Amsterdam, The Netherlands; 5: Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine and Health, Institute of Central Bohemia, Prague, Czech Republic; 6: University of Central Lancashire (UCLan), Faculty of Health, Preston, UK; 7: Westlakes Research Institute (WRI), Cumbria, UK; 8: Radiation and Nuclear Safety Authority (STUK), Helsinki, Finland; 9: Radiation Effects Research Foundation, Hiroshima, Japan; 10: Laboratory of Radiation Genetics, Central Research Institute of Roentgenology and Radiology, Russia; 11: Federal Office for Radiation Protection (BfS), Oberschleissheim, Germany; 12: National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA; 13: GSF-National Research Centre for Environment and Health, Institute of Radiobiology, Neuherberg, Germany; 14: Seoul National University, Department of Molecular Epidemiology, School of Public Health, Seoul, Republic of Korea; 15: Leiden University Medical Centre (LUMC), Department of Toxicogenetics, Leiden, The Netherlands; Issue Info: Apr2008, Vol. 652 Issue 2, p112; Thesaurus Term: Cigarette smokers; Subject Term: Persons; Subject Term: Addicts; Subject Term: Cigarettes; Author-Supplied Keyword: Background frequency; Author-Supplied Keyword: Chromosome translocations; Author-Supplied Keyword: Controls; Author-Supplied Keyword: Fluorescence in situ hybridization; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mrgentox.2008.01.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rongjun Wang
AU - Longxian Zhang
AU - Changshen Ning
AU - Yaoyu Feng
AU - Fuchun Jian
AU - Lihua Xiao
AU - Biao Lu
AU - Weichang Ai
AU - Heping Dong
T1 - Multilocus phylogenetic analysis of Cryptosporidium andersoni (Apicomplexa) isolated from a bactrian camel ( Camelus bactrianus ) in China.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2008/04/30/
VL - 102
IS - 5
M3 - Article
SP - 915
EP - 920
SN - 09320113
AB - Abstract This is the first report of cryptosporidiosis in a bactrian camel (Camelus bactrianus) in China. Two Cryptosporidium isolates derived from the same bactrian camel (3-year-old) in November 2005 and April 2006 were characterized using sequence and phylogenetic analysis of the small-subunit rRNA (18S rRNA), 70-kDa heat shock protein (HSP70), actin and Cryptosporidium oocyst wall protein (COWP) genes. The sequences of the 18S rRNA and COWP were identical to all other Cryptosporidium andersoni isolates although minor differences were noticed between the isolates and the USA isolate at the actin locus (99.2% of similarity). The sequence of the HSP70 was identical to the Japanese C. andersoni isolate, with a minor difference from the Australian C. andersoni isolate (99.7% of similarity). Cross-transmission studies demonstrated that the C. andersoni isolates did not infect immunosuppressed or immunocompetent Kun-ming mice, severe combined immunodeficiency mice, and immunosuppressed or immunocompetent calves. Among the C. andersoni isolates reported so far, only isolates from Japan could infect SCID mice. Thus, the C. andersoni isolates from the bactrian camel were biologically similar to most bovine C. andersoni isolates characterized so far, but are different from bovine isolates from Japan. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM
KW - PHYLOGENY
KW - BACTRIAN camel
KW - HEAT shock proteins
N1 - Accession Number: 32609281; Rongjun Wang 1 Longxian Zhang 1 Changshen Ning 1 Yaoyu Feng 2 Fuchun Jian 1 Lihua Xiao 3 Biao Lu 1 Weichang Ai 4 Heping Dong 1; Affiliation: 1: Henan Agricultural University The College of Animal Science and Veterinary Medicine Zhengzhou 450002 the People’s Republic of China 2: Chinese Center for Disease Control and Prevention National Institute for Parasitic Diseases Shanghai 200025 the People’s Republic of China 3: U.S. Department of Health and Human Services Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service Atlanta GA 30341 USA 4: The Wild Animals Rescue Center of Henan Province Zhengzhou 450044 the People’s Republic of China; Source Info: Apr2008, Vol. 102 Issue 5, p915; Subject Term: CRYPTOSPORIDIUM; Subject Term: PHYLOGENY; Subject Term: BACTRIAN camel; Subject Term: HEAT shock proteins; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kristin Elwin
AU - Rachel Chalmers
T1 - Contemporary identification of previously reported novel Cryptosporidium isolates reveals Cryptosporidium bovis and the cervine genotype in sheep ( Ovis aries ).
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2008/04/30/
VL - 102
IS - 5
M3 - Article
SP - 1103
EP - 1105
SN - 09320113
AB - Abstract  Molecular characterisation of Cryptosporidium spp. from sheep (Ovis aries), sampled during the investigation of a waterborne outbreak of human cryptosporidiosis caused by Cryptosporidium parvum, previously established that the sheep were not the source of infection. At the time, a novel Cryptosporidium genotype was identified at the Cryptosporidium oocyst wall protein locus in 26 isolates and a further ten isolates amplified with heat shock protein primers but remained unidentified. Subsequent investigation of small subunit ribosomal DNA has revealed that 22 samples contained Cryptosporidium cervine genotype, five contained Cryptosporidium bovis and four samples contained both the cervine genotype and C. bovis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIOSIS
KW - SHEEP diseases
KW - GENOTYPE-environment interaction
KW - GENETIC polymorphisms
N1 - Accession Number: 32609318; Kristin Elwin 1 Rachel Chalmers 1; Affiliation: 1: Singleton Hospital UK Cryptosporidium Reference Unit, National Public Health Service for Wales Microbiology Swansea Swansea SA2 8QA UK; Source Info: Apr2008, Vol. 102 Issue 5, p1103; Subject Term: CRYPTOSPORIDIOSIS; Subject Term: SHEEP diseases; Subject Term: GENOTYPE-environment interaction; Subject Term: GENETIC polymorphisms; NAICS/Industry Codes: 112410 Sheep Farming; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105748233
T1 - Outcomes for youth residential treatment programs using administrative data from the child welfare system: a risk-adjustment application.
AU - McMillen JC
AU - Lee BR
AU - Jonson-Reid M
Y1 - 2008/05//2008 May
N1 - Accession Number: 105748233. Language: English. Entry Date: 20080627. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed. Special Interest: Psychiatry/Psychology. NLM UID: 8914574.
KW - Child Welfare
KW - Mental Health Services -- Statistics and Numerical Data
KW - Outcome Assessment
KW - Risk Assessment -- Methods
KW - Adolescence
KW - Child
KW - Female
KW - Male
KW - Missouri
KW - Risk Assessment -- Statistics and Numerical Data
SP - 189
EP - 197
JO - Administration & Policy in Mental Health
JF - Administration & Policy in Mental Health
JA - ADM POLICY MENT HEALTH
VL - 35
IS - 3
CY - ,
PB - Springer Science & Business Media B.V.
SN - 0894-587X
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1196, St. Louis, MO, 63130, USA, cmcmille@wustl.edu.
U2 - PMID: 18176838.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Song-Iee Hong
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
AU - Wentz, Joan D.
AU - Rubin, Eugene
T1 - The quality of medical care for comorbid conditions of depressed elders.
JO - Aging & Mental Health
JF - Aging & Mental Health
Y1 - 2008/05//
VL - 12
IS - 3
M3 - Article
SP - 323
EP - 332
PB - Routledge
SN - 13607863
AB - Objectives: In light of large variation in the quality of medical care, this study assesses the extent to which medical care for depressed elders is consistent with systematic quality standards. Method: Using the Donabedian model, we assess factors related to two quality measures: medical service fit and medical provider contact. We assessed 110 depressed older adults with comorbid conditions through practical guidelines of medical services. Results: We found large variation in the quality of medical care and differences between two quality measures. Structure (Medigap insurance and clinical factors) and process factors (medical professional visits, ER visits, and adequacy of informal care) influenced the quality of medical care. Conclusion: Emphasizing accuracy in quality measures, quality disparities by medical conditions call attention to the risky population with certain conditions targeted for closer follow-up. Appropriate medical care processes can enhance the quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aging & Mental Health is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - COMORBIDITY
KW - EPIDEMIOLOGY
KW - MENTAL health
KW - PUBLIC health
KW - TREATMENT
KW - comorbidity
KW - medical provider contact
KW - medical service fit
KW - quality measurement
KW - quality of medical care
N1 - Accession Number: 34011084; Song-Iee Hong 1; Email Address: shong@gwbmail.wustl.edu Morrow-Howell, Nancy 1 Proctor, Enola 1 Wentz, Joan D. 2 Rubin, Eugene 3; Affiliation: 1: Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Missouri 2: Barnes-Jewish College of Nursing, St. Louis, Missouri 3: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; Source Info: May2008, Vol. 12 Issue 3, p323; Subject Term: MEDICAL care; Subject Term: COMORBIDITY; Subject Term: EPIDEMIOLOGY; Subject Term: MENTAL health; Subject Term: PUBLIC health; Subject Term: TREATMENT; Author-Supplied Keyword: comorbidity; Author-Supplied Keyword: medical provider contact; Author-Supplied Keyword: medical service fit; Author-Supplied Keyword: quality measurement; Author-Supplied Keyword: quality of medical care; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1080/13607860802121118
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105669723
T1 - The quality of medical care for comorbid conditions of depressed elders.
AU - Hong S
AU - Morrow-Howell N
AU - Proctor E
AU - Wentz JD
AU - Rubin E
Y1 - 2008/05//
N1 - Accession Number: 105669723. Language: English. Entry Date: 20081024. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Gerontologic Care; Psychiatry/Psychology. Grant Information: Funded by the National Institutes of Mental Health Grant (R01 MH56208). NLM UID: 9705773.
KW - Chronic Disease
KW - Depression
KW - Medical Care
KW - Process Assessment (Health Care)
KW - Quality of Health Care
KW - Aged
KW - Comorbidity
KW - Descriptive Statistics
KW - DSM
KW - Funding Source
KW - Male
KW - Prospective Studies
KW - Quality Assessment
KW - Record Review
KW - Repeated Measures
KW - Scales
KW - Urban Health Services
KW - Human
SP - 323
EP - 332
JO - Aging & Mental Health
JF - Aging & Mental Health
JA - AGING MENT HEALTH
VL - 12
IS - 3
CY - Oxfordshire,
PB - Routledge
AB - Objectives: In light of large variation in the quality of medical care, this study assesses the extent to which medical care for depressed elders is consistent with systematic quality standards. Method: Using the Donabedian model, we assess factors related to two quality measures: medical service fit and medical provider contact. We assessed 110 depressed older adults with comorbid conditions through practical guidelines of medical services. Results: We found large variation in the quality of medical care and differences between two quality measures. Structure (Medigap insurance and clinical factors) and process factors (medical professional visits, ER visits, and adequacy of informal care) influenced the quality of medical care. Conclusion: Emphasizing accuracy in quality measures, quality disparities by medical conditions call attention to the risky population with certain conditions targeted for closer follow-up. Appropriate medical care processes can enhance the quality.
SN - 1360-7863
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Missouri
U2 - PMID: 18728945.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hamilton, Jennifer L.
AU - Beatrix Roemheld-Hamm
AU - Young, Denise M.
AU - Jalba, Mihai
AU - DiCicco-Bloom, Barbara
T1 - COMPLEMENTARY AND ALTERNATIVE MEDICINE IN US FAMILY MEDICINE PRACTICES: A PILOT QUALITATIVE STUDY.
JO - Alternative Therapies in Health & Medicine
JF - Alternative Therapies in Health & Medicine
Y1 - 2008/05//May/Jun2008
VL - 14
IS - 3
M3 - Article
SP - 22
EP - 27
SN - 10786791
AB - Context • The growth of complementary and alternative medicine (CAM) has led some family medicine practices to include CAM. Acupuncture or herbal medicine, for example, may be offered at such practices. When a practice incorporates both CAM and conventional treatments, its goals and values may differ from those found in traditional primary care. Little is known about the development of these integrated practices, which may be expected to become more widespread. Objective • To identify some of the concepts and challenges shaping family medicine practices that incorporate CAM. Design • Comparative case study. Method • Multi-method assessment process including participant observation, key informant interviews, semi-structured depth interviews, and observation of patient-provider encounters. Setting • Four family medicine/CAM practices in the mid-Atlantic region of the United States. Results • Key themes that influence these practices' organization include dimensions of health, the selection of therapies used, the practices' approach to evidence, their perspective on the amount of time spent with patients, and their adaptations to financial concerns. Each practice emphasized long patient visits. In each, physicians had expertise that enabled them to draw on both conventional medicine and CAM. Conclusion • Successful incorporation of CAM modalities within a family medicine framework requires adaptation not only at the practice level but also by individual physicians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Alternative Therapies in Health & Medicine is the property of InnoVisions Professional Media and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALTERNATIVE medicine
KW - FAMILY medicine
KW - PHYSICIANS (General practice)
KW - MEDICAL care
KW - HERBAL medicine
N1 - Accession Number: 32997457; Hamilton, Jennifer L. 1 Beatrix Roemheld-Hamm 2 Young, Denise M. Jalba, Mihai DiCicco-Bloom, Barbara 3; Affiliation: 1: Assistant Professor, Department of Family, Community, and Preventive Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania. 2: Associate Professor and Director, Integrative medicine program, Department of Family Medicine, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, New Brunswick, New Jersey. 3: Assistant Professor and Director, Health Resources and Services Administration-funded National Health Service Research Fellowship, Department of Family Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey.; Source Info: May/Jun2008, Vol. 14 Issue 3, p22; Subject Term: ALTERNATIVE medicine; Subject Term: FAMILY medicine; Subject Term: PHYSICIANS (General practice); Subject Term: MEDICAL care; Subject Term: HERBAL medicine; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meyerhoefer, Chad D.
AU - Pylypchuk, Yuriy
AD - US Agency for Healthcare Research and Quality
AD - Social and Scientific Systems, Rockville, MD
T1 - Does Participation in the Food Stamp Program Increase the Prevalence of Obesity and Health Care Spending?
JO - American Journal of Agricultural Economics
JF - American Journal of Agricultural Economics
Y1 - 2008/05//
VL - 90
IS - 2
SP - 287
EP - 305
SN - 00029092
N1 - Accession Number: 0966507; Keywords: Food Stamp; Health; Obesity; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200805
N2 - We use panel data techniques and information on state-level Food Stamp Program characteristics to obtain unbiased estimates of the impact of Food Stamp Program participation on weight status and health care spending among nonelderly adults. Our results suggest that program participation by women leads to a 5.9% (p = 0.07) increase in their likelihood of overweight and obesity, which is smaller than previous estimates, and to higher medical expenditures. The direct effect of program participation on medical spending through higher discretionary income is significantly larger than the indirect effect through changes in weight status.
KW - Health Production I12
KW - Welfare, Well-Being, and Poverty: Government Programs; Provision and Effects of Welfare Programs I38
L3 - http://ajae.oxfordjournals.org/content/by/year
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UR - http://ajae.oxfordjournals.org/content/by/year
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
ID - 105741687
T1 - Role of FDA's drug information centers.
AU - Dada KC
AU - Kremzner ME
AU - Bhanot SK
AU - Lal R
Y1 - 2008/05//5/1/2008
N1 - Accession Number: 105741687. Language: English. Entry Date: 20080613. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9503023.
KW - Drug Information Services -- Legislation and Jurisprudence
KW - United States Food and Drug Administration
KW - Government Regulations
KW - United States
SP - 803
EP - 805
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 65
IS - 9
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Division of Drug Information Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20857, USA. kavita.dada@fda.hhs.gov
U2 - PMID: 18436726.
DO - 10.2146/ajhp070525
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105779843
T1 - Evidence shows cost and patient safety benefits of emergency pharmacists.
AU - Clancy CM
Y1 - 2008/05//May/Jun2008
N1 - Accession Number: 105779843. Language: English. Entry Date: 20080801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Emergency Service -- Administration
KW - Medication Errors -- Prevention and Control
KW - Pharmacy Service -- Administration
KW - Attitude of Health Personnel
KW - Emergency Service -- Economics
KW - Pharmacy Service -- Economics
KW - Safety
SP - 231
EP - 233
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 23
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 18539985.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105655926
T1 - The issue is... Occupational therapists' role on U.S. Army and U.S. Public Health Service Commissioned Corps disaster mental health response teams.
AU - Oakley F
AU - Caswell S
AU - Parks R
Y1 - 2008/05//May/Jun2008
N1 - Accession Number: 105655926. Language: English. Entry Date: 20081003. Revision Date: 20150819. Publication Type: Journal Article. Journal Subset: Allied Health; Peer Reviewed; USA. Special Interest: Occupational Therapy. NLM UID: 7705978.
KW - Disaster Planning
KW - Emergencies
KW - Government Agencies
KW - Mental Health
KW - Military Services
KW - Occupational Therapy
KW - Professional Role
KW - Public Health
KW - Iraq
KW - Terrorism
KW - United States
SP - 361
EP - 364
JO - American Journal of Occupational Therapy
JF - American Journal of Occupational Therapy
JA - AM J OCCUP THER
VL - 62
IS - 3
CY - Bethesda, Maryland
PB - American Occupational Therapy Association
SN - 0272-9490
AD - Captain, U.S. Public Health Service, Occupational Therapy Section, Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, MD 20892-1604; foakley@nih.gov
U2 - PMID: 18557012.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105745045
T1 - AHRQ commentary. Slowed progress in improving quality and minimizing disparities.
AU - Brady J
AU - Ho K
AU - Clancy CM
Y1 - 2008/05//
N1 - Accession Number: 105745045. Language: English. Entry Date: 20080620. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0372403.
KW - Patient Safety
KW - Quality Improvement
KW - Quality of Health Care -- Trends
SP - 1007
EP - 1009
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 87
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Lead Staff for National Healthcare Quality Report, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 18489923.
DO - 10.1016/j.aorn.2008.04.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105745045&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Su-Ryun
AU - Bae, Yun-Hee
AU - Bae, Soo-Kyung
AU - Choi, Kyu-Sil
AU - Yoon, Kwon-Ha
AU - Koo, Tae Hyeon
AU - Jang, Hye-Ock
AU - Yun, Il
AU - Kim, Kyu-Won
AU - Kwon, Young-Guen
AU - Yoo, Mi-Ae
AU - Bae, Moon-Kyoung
T1 - Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-κB activation in endothelial cells
JO - BBA - Molecular Cell Research
JF - BBA - Molecular Cell Research
Y1 - 2008/05//
VL - 1783
IS - 5
M3 - Article
SP - 886
EP - 895
SN - 01674889
AB - Abstract: Visfatin has recently been identified as a novel visceral adipokine which may be involved in obesity-related vascular disorders. However, it is not known whether visfatin directly contributes to endothelial dysfunction. Here, we investigated the effect of visfatin on vascular inflammation, a key step in a variety of vascular diseases. Visfatin induced leukocyte adhesion to endothelial cells and the aortic endothelium by induction of the cell adhesion molecules, ICAM-1 and VCAM-1. Promoter analysis revealed that visfatin-mediated induction of CAMs is mainly regulated by nuclear factor-κB (NF-κB). Visfatin stimulated IκBα phosphorylation, nuclear translocation of the p65 subunit of NF-κB, and NF-κB DNA binding activity in HMECs. Furthermore, visfatin increased ROS generation, and visfatin-induced CAMs expression and NF-κB activation were abrogated in the presence of the direct scavenger of ROS. Taken together, our results demonstrate that visfatin is a vascular inflammatory molecule that increases expression of the inflammatory CAMs, ICAM-1 and VCAM-1, through ROS-dependent NF-κB activation in endothelial cells. [Copyright &y& Elsevier]
AB - Copyright of BBA - Molecular Cell Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARTERIAL catheterization
KW - PHOSPHORYLATION
KW - INFLAMMATION
KW - GENE expression
KW - Cell adhesion molecules
KW - NF-κB
KW - Reactive oxygen species
KW - Vascular inflammation
KW - Visfatin
N1 - Accession Number: 31750677; Kim, Su-Ryun 1,2 Bae, Yun-Hee 3 Bae, Soo-Kyung 3 Choi, Kyu-Sil 4 Yoon, Kwon-Ha 4 Koo, Tae Hyeon 5 Jang, Hye-Ock 1 Yun, Il 1 Kim, Kyu-Won 6 Kwon, Young-Guen 7 Yoo, Mi-Ae 2; Email Address: mayoo@pusan.ac.kr Bae, Moon-Kyoung 1; Email Address: mkbae@pusan.ac.kr; Affiliation: 1: School of Dentistry, Pusan National University, Pusan 602-739, South Korea 2: Department of Molecular Biology, College of Natural Science, Pusan National University, Pusan 609-735, South Korea 3: Medical Research Center for Ischemic Tissue Regeneration, School of Medicine, Pusan National University, Pusan 602-739, South Korea 4: Department of Radiology and Institute for Radiological Imaging Science, Wonkwang University School of Medicine, Iksan, 570-749, South Korea 5: Korea Food and Drug Administration, Pusan 608-080, South Korea 6: College of Pharmacy, Seoul National University, Seoul 151-742, South Korea 7: Department of Biochemistry, College of Sciences, Yonsei University, Seoul 120-749, South Korea; Source Info: May2008, Vol. 1783 Issue 5, p886; Subject Term: ARTERIAL catheterization; Subject Term: PHOSPHORYLATION; Subject Term: INFLAMMATION; Subject Term: GENE expression; Author-Supplied Keyword: Cell adhesion molecules; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Vascular inflammation; Author-Supplied Keyword: Visfatin; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bbamcr.2008.01.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31750677&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zivny, Jan H.
AU - Gelderman, Monique P.
AU - Xu, Fei
AU - Piper, John
AU - Holada, Karel
AU - Simak, Jan
AU - Vostal, Jaroslav G.
T1 - Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp−/−) mice
JO - Blood Cells, Molecules & Diseases
JF - Blood Cells, Molecules & Diseases
Y1 - 2008/05//
VL - 40
IS - 3
M3 - Article
SP - 302
EP - 307
SN - 10799796
AB - Abstract: Cellular prion protein (PrPc) participates in the pathogenesis of prion diseases but its normal function remains unclear. PrPc is expressed on hematopoietic cells, including erythroid precursors. We investigated the role of PrPc in erythropoiesis in vivo with phenylhydrazine-induced acute anemia. Induction of equivalent anemia in wild-type (WT) and Prnp−/− mice resulted in a higher number of circulating reticulocytes, hematocrits and spleen weights in WT mice than in Prnp−/− mice on Days 5 and 7. Examination of bone marrow erythroid precursor cells (Ter119+) on Day 5 revealed no significant differences in the number of these cells between the two types of animals. However, a higher percentage of Ter119+ cells were going through apoptosis in Prnp−/− mice than in WT mice. Plasma erythropoietin (Epo) levels and Epo mRNA in kidneys peaked on Day 3 in response to anemia for both types of animals but rose less in Prnp−/− (5500 pg/ml ) than in WT (18,000 pg/ml) animals. Administration of recombinant human Epo to mice produced an equivalent reticulocyte response in both types of animals suggesting that the potential for erythroid generation is intact in Prnp−/− animals. These observations indicate that PrPc may modulate tissue hypoxia-sensing mechanisms or effect hypoxia target gene expression. [Copyright &y& Elsevier]
AB - Copyright of Blood Cells, Molecules & Diseases is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRION diseases
KW - ERYTHROPOIETIN
KW - BONE marrow
KW - ERYTHROPOIESIS
KW - EXAMINATION
KW - Anemia
KW - Erythroid cell
KW - Erythropoietin
KW - Prion protein
KW - Ter119+
N1 - Accession Number: 31757428; Zivny, Jan H. 1 Gelderman, Monique P. 2 Xu, Fei 2 Piper, John 2 Holada, Karel 1 Simak, Jan 2 Vostal, Jaroslav G. 2; Email Address: jaroslav.vostal@fda.hhs.gov; Affiliation: 1: 1st School of Medicine, Charles University, Prague, Czech Republic 2: Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, USA; Source Info: May2008, Vol. 40 Issue 3, p302; Subject Term: PRION diseases; Subject Term: ERYTHROPOIETIN; Subject Term: BONE marrow; Subject Term: ERYTHROPOIESIS; Subject Term: EXAMINATION; Author-Supplied Keyword: Anemia; Author-Supplied Keyword: Erythroid cell; Author-Supplied Keyword: Erythropoietin; Author-Supplied Keyword: Prion protein; Author-Supplied Keyword: Ter119+; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bcmd.2007.09.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Plaut, Roger D.
AU - Carbonetti, Nicholas H.
T1 - Retrograde transport of pertussis toxin in the mammalian cell.
JO - Cellular Microbiology
JF - Cellular Microbiology
Y1 - 2008/05//
VL - 10
IS - 5
M3 - Article
SP - 1130
EP - 1139
PB - Wiley-Blackwell
SN - 14625814
AB - Pertussis toxin (PT), an AB5 exotoxin and important virulence factor of Bordetella pertussis, is hypothesized to traffic along a retrograde transport pathway in mammalian cells. This pathway includes endosomal uptake, transport to the Golgi complex and endoplasmic reticulum (ER), dissociation of the holotoxin in the ER and translocation of the A subunit (S1) to the cytosol, where it ADP-ribosylates its G protein targets. In this study, PT was visualized in the Golgi complex by immunofluorescence microscopy, but transport beyond the Golgi could not be detected by this method. To gain evidence for the retrograde pathway, peptide tags with target sites for tyrosine sulfation (a trans-Golgi network-specific activity) and N-glycosylation (an ER-specific activity) were added to either S1 or a B subunit (S4) of PT. Modified PT retained in vitro enzymatic and cellular activity as assessed by ADP-ribosylation assays. Peptide-tagged PT subunits were found to be modified by tyrosine sulfation, and, at later time points, by N-glycosylation. Appearance of sulfated PT subunits was inhibited by pretreatment of cells with brefeldin A. In some cell types, much of the S4 glycosylation, but not that of S1, was resistant to endoglycosidase H, suggesting that, subsequent to core N-glycosylation in the ER, S4 was transported anterograde to the Golgi, where further glycosylation occurred. When cells were pretreated with methyl-β-cyclodextrin, sulfation of PT subunits and PT cytotoxicity were reduced, suggesting that PT transport is dependent on cellular cholesterol content. These data support a retrograde pathway for PT intracellular transport. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTERIFICATION
KW - GLYCOSYLATION
KW - AMINO acids
KW - TYROSINE
KW - BACTERIAL toxins
KW - CELLULAR signal transduction
KW - G proteins
KW - SCISSION (Chemistry)
KW - IMMUNOFLUORESCENCE
KW - ISOPENTENOIDS
N1 - Accession Number: 31591859; Plaut, Roger D. 1,2 Carbonetti, Nicholas H. 1; Email Address: ncarbone@umaryland.edu; Affiliation: 1: Department of Microbiology and Immunology, University of Maryland School of Medicine, 660 W. Redwood St., HH 324, Baltimore MD 21201, USA 2: Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA; Source Info: May2008, Vol. 10 Issue 5, p1130; Subject Term: ESTERIFICATION; Subject Term: GLYCOSYLATION; Subject Term: AMINO acids; Subject Term: TYROSINE; Subject Term: BACTERIAL toxins; Subject Term: CELLULAR signal transduction; Subject Term: G proteins; Subject Term: SCISSION (Chemistry); Subject Term: IMMUNOFLUORESCENCE; Subject Term: ISOPENTENOIDS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 10p; Illustrations: 4 Black and White Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1462-5822.2007.01115.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Muller, Veronika
AU - Szabo, Attila J.
AU - Erderly, Aaron
AU - You-Lin Tain
AU - Baylis, Chris
T1 - SEX DIFFERENCES IN RESPONSE TO CYCLOSPORINE IMMUNOSUPPRESSION IN EXPERIMENTAL KIDNEY TRANSPLANTATION.
JO - Clinical & Experimental Pharmacology & Physiology
JF - Clinical & Experimental Pharmacology & Physiology
Y1 - 2008/05//May/Jun2008
VL - 35
IS - 5/6
M3 - Article
SP - 574
EP - 579
PB - Wiley-Blackwell
SN - 03051870
AB - 1. Female donors and recipients have increased risk of acute rejection and subsequent chronic allograft nephropathy (CAN), especially when cyclosporine A (CsA) is used. Decreased renal nitric oxide (NO) production is associated with chronic kidney disease. In the present study, we investigated the impact of gender, CsA dose and renal NO synthase (NOS) on CAN. 2. Kidneys from male and female F344 rats were transplanted into same-sex Lewis allograft or F344 isograft recipients and recipient rats were treated with 1.5 or 3 mg/kg per day CsA for 10 days. Grafts were removed at 22 weeks post-transplantation. Normal two-kidney F344 rats were investigated as age-matched controls. 3. Low-dose CsA was associated with accelerated CAN in female rats compared with male rats; however, with high-dose CsA, allograft females had similar pathology/function to allograft males. Isograft females (similar to isograft males) had no graft failure and only slightly, albeit significantly, greater injury than age-matched controls. Isograft females had higher renal cortical neuronal (n) NOS but lower medullary endothelial (e) NOS than isograft males. There was no difference in renal eNOS and nNOS between allograft groups. 4. In conclusion, 1.5 mg/kg per day CsA is not sufficient to prevent early graft loss in females. When the dose of CsA is doubled, allograft females and males have similar post-transplant survival. Renal NOS expression was unremarkable in any transplant group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Pharmacology & Physiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOSPORINE
KW - IMMUNOSUPPRESSION
KW - KIDNEY transplants
KW - RATS as laboratory animals
KW - SEX differences (Biology)
KW - cyclosporine
KW - immunosuppression
KW - kidney transplantation
KW - sex difference
N1 - Accession Number: 31506957; Muller, Veronika 1 Szabo, Attila J. 2 Erderly, Aaron 3 You-Lin Tain 4,5 Baylis, Chris 4; Email Address: baylisc@ufl.edu; Affiliation: 1: Departments of Pulmonology, Semmelweis University, Budapest, Hungary 2: Departments of Pediatrics, Semmelweis University, Budapest, Hungary 3: Departments of Toxicology and Molecular Biology Branch, National Institute of Occupational Safety and Health, Morgantown, West Virginia 4: Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA 5: Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan; Source Info: May/Jun2008, Vol. 35 Issue 5/6, p574; Subject Term: CYCLOSPORINE; Subject Term: IMMUNOSUPPRESSION; Subject Term: KIDNEY transplants; Subject Term: RATS as laboratory animals; Subject Term: SEX differences (Biology); Author-Supplied Keyword: cyclosporine; Author-Supplied Keyword: immunosuppression; Author-Supplied Keyword: kidney transplantation; Author-Supplied Keyword: sex difference; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1440-1681.2007.04841.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31506957&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barczak, Thomas M.
AU - Tadouni, Stephen C.
T1 - LONGWALL SHIELD DESIGN: IS BIGGER BETTER?
JO - Coal Age
JF - Coal Age
Y1 - 2008/05//
VL - 113
IS - 5
M3 - Article
SP - 26
EP - 33
PB - Mining Media Inc.
SN - 10407820
AB - The article focuses on the bigger-the-better concept for longwall shields in coal mining. The conventional support design approach is replaced by a ground reaction design approach. The steady increase in shield capacity resulted in larger support structures. An alternative approach would be to develop a smart loading technology design that uses the capacity only when it is needed.
KW - COAL mines & mining
KW - TECHNOLOGICAL innovations
KW - EQUIPMENT & supplies
KW - LONGWALL mining -- Equipment & supplies
KW - LOAD factor design
KW - STRUCTURAL design
N1 - Accession Number: 32528496; Barczak, Thomas M. 1; Email Address: tbarczak@cdc.gov; Tadouni, Stephen C. 2; Affiliations: 1: Senior research engineer for the National Institute for Occupational Safety and Health-Pittsburgh Research Laboratory (NIOSH-PRL); 2: Chief, rock safety engineering branch for NIOSH-PRL; Issue Info: May2008, Vol. 113 Issue 5, p26; Thesaurus Term: COAL mines & mining; Thesaurus Term: TECHNOLOGICAL innovations; Subject Term: EQUIPMENT & supplies; Subject Term: LONGWALL mining -- Equipment & supplies; Subject Term: LOAD factor design; Subject Term: STRUCTURAL design; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); Number of Pages: 8p; Illustrations: 3 Diagrams, 5 Graphs; Document Type: Article; Full Text Word Count: 6635
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105757346
T1 - Food and Drug Administration approval process for ophthalmic drugs in the US.
AU - Lloyd R
AU - Harris J
AU - Wadhwa S
AU - Chambers W
Y1 - 2008/05//2008 May
N1 - Accession Number: 105757346. Language: English. Entry Date: 20080704. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9011108.
KW - Drug Approval -- Methods
KW - United States Food and Drug Administration -- Standards
KW - Drug Design -- Methods
KW - Ophthalmology
KW - United States
SP - 190
EP - 194
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
JA - CURR OPIN OPHTHALMOL
VL - 19
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - PURPOSE OF REVIEW: The purpose of this review is to provide the overall framework of the review and approval of ophthalmic drugs in the US. RECENT FINDINGS: Examples from the recent approval of the ranibizumab injection (Lucentis; Genentech, South San Francisco, California, USA) are offered to illustrate the current approval process at the Food and Drug Administration (FDA). SUMMARY: New drugs are brought to the US market after review of the New Drug Application or Biologic License Application by the FDA. This review process requires the teamwork of an interdisciplinary team of clinicians, scientists and regulatory personnel. This team is ultimately responsible for recommending to the Secretary of Health and Human Services (or designee) the approvability of a drug based on defined requirements including the drug's risk/benefit profile, quality and purity, and the drug's ability to be labeled effectively. Within the Center for Drug Evaluation and Research this review team for ophthalmic drugs resides primarily within the Division of Anti-Infective and Ophthalmology Products.
SN - 1040-8738
AD - Division of Anti-Infective and Ophthalmology Products, US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA.
U2 - PMID: 18408492.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105757346&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chipinda, Itai
AU - Zhang, Xing-Dong
AU - Simoyi, Reuben H.
AU - Siegel, Paul D.
T1 - Mercaptobenzothiazole allergenicity—role of the thiol group.
JO - Cutaneous & Ocular Toxicology
JF - Cutaneous & Ocular Toxicology
Y1 - 2008/05//
VL - 27
IS - 2
M3 - Article
SP - 103
EP - 116
PB - Taylor & Francis Ltd
SN - 15569527
AB - The rubber accelerator, 2-mercaptobenzothiazole (MBT), is known to cause allergic contact dermatitis (ACD), but the mechanism is unknown. The role of the thiol group in MBT's allergenicity was investigated in the present study. Guinea pigs were sensitized to MBT using a modified guinea pig maximization test (GPMT) and reactivity was assessed toward 2-mercaptobenzothiazole disulfide (MBTS), 2-hydroxybenzothiazole (HBT; thiol-substituted), 2-(methylthio)benzothiazole (MTBT; thiol-blocked), and benzothiazole (BT; thiol-lacking). MBT and MBTS, but not BT, HBT, or MTBT, elicited ACD in MBT-sensitized animals, demonstrating that the thiol group is critical to MBT's allergenicity. In addition, both MBT and MBTS were shown to inhibit both glutathione reductase and thioredoxin reductase, and thus contribute to the stability of MBT-protein mixed disulfides. It is concluded that the probable haptenation mechanism of MBT is through initial oxidation to MBTS with subsequent reduction to form mixed disulfides with proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Organosulfur compounds
KW - Skin -- Inflammation
KW - Thiols
KW - Contact dermatitis
KW - Delayed hypersensitivity
KW - Vulcanization accelerators
KW - Glutathione
KW - Proteins
KW - Allergenicity
KW - Mercaptobenzothiazole
KW - Thiol
KW - Vulcanization accelerator
N1 - Accession Number: 32707189; Chipinda, Itai 1; Zhang, Xing-Dong 2; Simoyi, Reuben H. 3; Siegel, Paul D. 2; Email Address: pds3@cdc.gov; Affiliations: 1: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA,Department of Chemistry, Portland State University, Portland, Oregon, USA; 2: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 3: Department of Chemistry, Portland State University, Portland, Oregon, USA; Issue Info: 2008, Vol. 27 Issue 2, p103; Thesaurus Term: Allergy; Thesaurus Term: Organosulfur compounds; Subject Term: Skin -- Inflammation; Subject Term: Thiols; Subject Term: Contact dermatitis; Subject Term: Delayed hypersensitivity; Subject Term: Vulcanization accelerators; Subject Term: Glutathione; Subject Term: Proteins; Author-Supplied Keyword: Allergenicity; Author-Supplied Keyword: Mercaptobenzothiazole; Author-Supplied Keyword: Thiol; Author-Supplied Keyword: Vulcanization accelerator; Number of Pages: 14p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15569520701713008
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cederroth, Christopher R.
AU - Vinciguerra, Manlio
AU - Gjinovci, Asllan
AU - Kühne, Françoise
AU - Klein, Marcella
AU - Cederroth, Manon
AU - Caille, Dorothée
AU - Suter, Mariane
AU - Neumann, Dietbert
AU - James, Richard W.
AU - Doerge, Daniel R.
AU - Wallimann, Theo
AU - Meda, Paolo
AU - Foti, Michelangelo
AU - Rohner-Jeanrenaud, Françoise
AU - Vassalli, Jean-Dominique
AU - Nef, Serge
T1 - Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism.
JO - Diabetes
JF - Diabetes
Y1 - 2008/05//
VL - 57
IS - 5
M3 - Article
SP - 1176
EP - 1185
SN - 00121797
AB - OBJECTIVE -- Emerging evidence suggests that dietary phytoestrogens can have beneficial effects on obesity and diabetes, although their mode of action is not known. Here, we investigate the mechanisms mediating the action of dietary phytoestrogens on lipid and glucose metabolism in rodents. RESEARCH DESIGN AND METHODS -- Male CD-1 mice were fed from conception to adulthood with either a high soy-containing diet or a soy-free diet. Serum levels of circulating isoflavones, ghrelin, leptin, free fatty acids, triglycerides, and cholesterol were quantified. Tissue samples were analyzed by quantitative RT-PCR and Western blotting to investigate changes of gene expression and phosphorylation state of key metabolic proteins. Glucose and insulin tolerance tests and euglycemic-hyperinsulinemic clamp were used to assess changes in insulin sensitivity and glucose uptake. In addition, insulin secretion was determined by in situ pancreas perfusion. RESULTS -- In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism. CONCLUSIONS -- Dietary soy could prove useful to prevent obesity and associated disorders. Activation of the AMPK pathway by dietary soy is likely involved and may mediate the beneficial effects of dietary soy in peripheral tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYTOESTROGENS
KW - ADIPOSE tissues
KW - LIPID metabolism
KW - GLUCOSE
KW - DIABETES
KW - MICE as laboratory animals
N1 - Accession Number: 32202872; Cederroth, Christopher R. 1 Vinciguerra, Manlio 2 Gjinovci, Asllan 2 Kühne, Françoise 1 Klein, Marcella 3 Cederroth, Manon 1 Caille, Dorothée 2 Suter, Mariane 4 Neumann, Dietbert 4 James, Richard W. 5 Doerge, Daniel R. 6 Wallimann, Theo 4 Meda, Paolo 2 Foti, Michelangelo 2 Rohner-Jeanrenaud, Françoise 3 Vassalli, Jean-Dominique 1 Nef, Serge 1; Email Address: serge.nef@medecine.unige.ch; Affiliation: 1: Department of Genetic Medicine and Development and National Centre of Competence in Research-Frontiers in Genetics, University of Geneva, Geneva, Switzerland 2: Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland 3: The Laboratory of Metabolism, University of Geneva, Geneva, Switzerland 4: The Institute of Cell Biology, ETH Zürich, Zürich, Switzerland 5: The Clinical Diabetes Unit, Division of Endocrinology, Diabetology, and Nutrition, Faculty of Medicine, Department of Internal Medicine, University of Geneva, Geneva, Switzerland 6: National Center for Toxicological Research, Jefferson, Arkansas; Source Info: May2008, Vol. 57 Issue 5, p1176; Subject Term: PHYTOESTROGENS; Subject Term: ADIPOSE tissues; Subject Term: LIPID metabolism; Subject Term: GLUCOSE; Subject Term: DIABETES; Subject Term: MICE as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article; Full Text Word Count: 7566
L3 - 10.2337/db07-0630
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32202872&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105754955
T1 - NIDA drug supply and analytical services program: providing research resources and tools to the scientific community.
AU - Singh HH
AU - Rapaka RS
AU - Shurtleff D
AU - De La Garza R
Y1 - 2008/05//
N1 - Accession Number: 105754955. Language: English. Entry Date: 20080704. Revision Date: 20150711. Publication Type: Journal Article; review. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Psychiatry/Psychology. NLM UID: 7513587.
KW - Drug Administration
KW - Government Programs
KW - Information Resources
KW - National Institute on Drug Abuse (U.S.) -- Administration
KW - Research
KW - Seminars and Workshops
KW - Substance Abuse
KW - United States
SP - 182
EP - 186
JO - Drug & Alcohol Dependence
JF - Drug & Alcohol Dependence
JA - DRUG ALCOHOL DEPENDENCE
VL - 95
IS - 1/2
PB - Elsevier Science
SN - 0376-8716
AD - Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892; hsingh1@mail.nih.gov
U2 - PMID: 18484110.
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DP - EBSCOhost
DB - rzh
ER -
TY -
AU - O'Neill, Robert T.1, ROBERT.ONEILL@fda.hhs.gov
T1 - A Perspective on Characterizing Benefits and Risks Derived From Clinical Trials: Can We Do More?
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2008/05//
Y1 - 2008/05//
VL - 42
IS - 3
CP - 3
M3 - Article
SP - 235
EP - 245
SN - 00928615
AB - This article considers a variety of issues associated with the role that clinical trials play in the evaluation of the benefits and risks (hams) of new therapies and with the communication of quantitatively assessed benefits and risks based upon the evidence derived from clinical trials. The article is organized into several sections that explore and discuss aspects of the challenging area of characterizing benefits and risks from clinical trials. We begin with a background on the interest in the topic, and then consider a theme that argues for the imbalance or asymmetry in the way benefits and risks in clinical trials are currently characterized, using examples from the medical literature to illustrate the points. We then comment on several topics, such as metrics for benefit:risk that are involved in other aspects of benefit:risk analysis, which relate to other articles in this issue. Finally, we make some concluding remarks on how to make progress in the future to improve benefit:risk analysis in clinical trials. [ABSTRACT FROM AUTHOR]
KW - Clinical trials
KW - Health risk assessment
KW - Therapeutics
KW - Medical research
KW - Public health
KW - Preventive medicine
KW - Benefit
KW - Clinical trial
KW - Follow-up
KW - Metrics
KW - Risk
KW - Study design
KW - Withdrawals
N1 - Accession Number: 32110641; Authors: O'Neill, Robert T. 1 Email Address: ROBERT.ONEILL@fda.hhs.gov; Affiliations: 1: Center for Drug Evaluation and Research, FDA; Subject: Clinical trials; Subject: Health risk assessment; Subject: Therapeutics; Subject: Medical research; Subject: Public health; Subject: Preventive medicine; Author-Supplied Keyword: Benefit; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Follow-up; Author-Supplied Keyword: Metrics; Author-Supplied Keyword: Risk; Author-Supplied Keyword: Study design; Author-Supplied Keyword: Withdrawals; Number of Pages: 11p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Fox, Donald A.
AU - Kala, Subbarao V.
AU - Hamilton, W. Ryan
AU - Johnson, Jerry E.
AU - O'Callaghan, James P.
T1 - Low-Level Human Equivalent Gestational Lead Exposure Produces Supernormal Scotopic Electroretinograms, Increased Retinal Neurogenesis, and Decreased Retinal Dopamine Utilization in Rats. (cover story)
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/05//
VL - 116
IS - 5
M3 - Article
SP - 618
EP - 625
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Postnatal lead exposure in children and animals produces alterations in the visual system primarily characterized by decreases in the rod-mediated (scotopic) electroretinogram (ERG) amplitude (subnormality). In contrast, low-level gestational Pb exposure (GLE) increases the amplitude of scotopic ERGs in children (supernormality). OBJECTIVES: The goal of this study was to establish a rat model of human equivalent GLE and to determine dose-response effects on scotopic ERGs and on retinal morphology, biochemistry, and dopamine metabolism in adult offspring. METHODS: We exposed female Long-Evans hooded rats to water containing 0, 27 (low), 55 (moderate), or 109 (high) ppm of Pb beginning 2 weeks before mating, throughout gestation, and until postnatal day (PND) 10. We measured maternal and litter indices, blood Pb concentrations (BPb), retinal Pb concentrations, zinc concentrations, and body weights. On PND90, we performed the retinal experiments. RESULTS: Peak BPb concentrations were < 1, 12, 24, and 46 μg/dL in control, low-, moderate- and high-level GLE groups, respectively, at PNDs 0-10. ERG supernormality and an increased rod photoreceptor and rod bipolar cell neurogenesis occurred with low- and moderate-level GLE. In contrast, high-level GLE produced ERG subnormality, rod cell loss, and decreased retinal Zn levels. GLE produced dose-dependent decreases in dopamine and its utilization. CONCLUSIONS: Low- and moderate-level GLE produced persistent scotopic ERG supernormality due to an increased neurogenesis of cells in the rod signaling pathway and/or decreased dopamine utilization, whereas high-level GLE produced rod-selective toxicity characterized by ERG subnormality. The ERG is a differential and noninvasive biomarker of GLE. The inverted U-shaped dose-response curves reveal the sensitivity and vulnerability of the developing retina to GLE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Lead in the body
KW - Rats
KW - Pregnancy in animals
KW - Prenatal influences
KW - Retina -- Abnormalities
KW - Electroretinography
KW - Developmental neurobiology
KW - Dopamine
KW - bipolar cells
KW - development
KW - dopamine
KW - electroretinograms
KW - gestation
KW - lead
KW - neuro-genesis
KW - rod photoreceptors
KW - scotopic
KW - zinc.
N1 - Accession Number: 32712654; Fox, Donald A. 1,2,3; Email Address: dafox@uh.edu; Kala, Subbarao V. 4; Hamilton, W. Ryan 2; Johnson, Jerry E. 5; O'Callaghan, James P. 6; Affiliations: 1: College of Optometry, University of Houston, Houston, Texas, USA.; 2: Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA.; 3: Department of Pharmacology and Pharmaceutical Sciences, University of Houston, Houston, Texas, USA.; 4: One Source Toxicology Laboratory, Inc., Pasadena, Texas, USA.; 5: Department of Natural Sciences, University of Houston-Downtown, Houston, Texas, USA.; 6: Toxicology and Molecular Biology Branch, Health Effects Research Laboratory, Centers for Disease Control and Prevention-National Institute of Occupational Safety and Health, Morgantown, West Virginia, USA.; Issue Info: May2008, Vol. 116 Issue 5, p618; Thesaurus Term: RESEARCH; Subject Term: Lead in the body; Subject Term: Rats; Subject Term: Pregnancy in animals; Subject Term: Prenatal influences; Subject Term: Retina -- Abnormalities; Subject Term: Electroretinography; Subject Term: Developmental neurobiology; Subject Term: Dopamine; Author-Supplied Keyword: bipolar cells; Author-Supplied Keyword: development; Author-Supplied Keyword: dopamine; Author-Supplied Keyword: electroretinograms; Author-Supplied Keyword: gestation; Author-Supplied Keyword: lead; Author-Supplied Keyword: neuro-genesis; Author-Supplied Keyword: rod photoreceptors; Author-Supplied Keyword: scotopic; Author-Supplied Keyword: zinc.; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 1 Diagram, 1 Chart, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pohl, Hana R.
AU - Tarkowski, Stanislaw
AU - Buczynska, Alina
AU - Fay, Mike
AU - De Rosa, Christopher T.
T1 - Chemical exposures at hazardous waste sites: Experiences from the United States and Poland
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2008/05//
VL - 25
IS - 3
M3 - Article
SP - 283
EP - 291
SN - 13826689
AB - Abstract: The U.S. Agency for Toxic Substances and Disease Registry (ATSDR) and the Polish Nofer Institute of Occupational Health collaborate on issues related to hazardous chemical exposure at or near hazardous waste sites. This paper outlines the scope of hazardous chemical exposure in the United States and in Poland and identifies priority chemicals and chemical mixtures. Special attention is paid to exposures to metals and to evaluation of the health risks associated with those exposures. Studies in the United States indicate that exposure to hazardous waste site chemicals may be associated with an increased risk of adverse developmental – specifically cardiovascular and neurodevelopmental – effects. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAZARDOUS waste treatment facilities
KW - PUBLIC health -- United States
KW - CHEMICALS
KW - EVALUATION
KW - WASTE products
KW - HAZARDOUS waste sites -- Evaluation
KW - UNITED States
KW - POLAND
KW - Agency for Toxic Substances and Disease Registry ( ATSDR )
KW - binary weight-of-evidence ( BINWOE )
KW - Chemical mixtures
KW - Developmental effects
KW - Environmental Protection Agency ( EPA )
KW - Hazardous chemicals
KW - letter of agreement ( LOA )
KW - Metals
KW - minimal risk levels ( MRLs )
KW - national priority list ( NPL )
KW - toxics release inventory ( TRI )
N1 - Accession Number: 30018654; Pohl, Hana R. 1; Email Address: hpohl@cdc.gov Tarkowski, Stanislaw 2 Buczynska, Alina 2 Fay, Mike 1 De Rosa, Christopher T. 1; Affiliation: 1: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA 2: Nofer Institute of Occupational Health, Łódź, Poland; Source Info: May2008, Vol. 25 Issue 3, p283; Subject Term: HAZARDOUS waste treatment facilities; Subject Term: PUBLIC health -- United States; Subject Term: CHEMICALS; Subject Term: EVALUATION; Subject Term: WASTE products; Subject Term: HAZARDOUS waste sites -- Evaluation; Subject Term: UNITED States; Subject Term: POLAND; Author-Supplied Keyword: Agency for Toxic Substances and Disease Registry ( ATSDR ); Author-Supplied Keyword: binary weight-of-evidence ( BINWOE ); Author-Supplied Keyword: Chemical mixtures; Author-Supplied Keyword: Developmental effects; Author-Supplied Keyword: Environmental Protection Agency ( EPA ); Author-Supplied Keyword: Hazardous chemicals; Author-Supplied Keyword: letter of agreement ( LOA ); Author-Supplied Keyword: Metals; Author-Supplied Keyword: minimal risk levels ( MRLs ); Author-Supplied Keyword: national priority list ( NPL ); Author-Supplied Keyword: toxics release inventory ( TRI ); NAICS/Industry Codes: 562210 Waste treatment and disposal; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 562111 Solid Waste Collection; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 423930 Recyclable Material Merchant Wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.etap.2007.12.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105498703
T1 - Estimating the coverage of a targeted mobile tuberculosis screening programme among illicit drug users and homeless persons with truncated models.
AU - van Hest NA
AU - De Vries G
AU - Smit F
AU - Grant AD
AU - Richardus JH
Y1 - 2008/05//
N1 - Accession Number: 105498703. Language: English. Entry Date: 20090417. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Health Screening -- Methods
KW - Health Services Research
KW - Mobile Health Units
KW - Tuberculosis -- Diagnosis
KW - Homeless Persons
KW - Models, Statistical
KW - Netherlands
KW - Radiography, Thoracic -- Utilization
KW - Street Drugs
KW - Substance Use Disorders
KW - Human
SP - 628
EP - 635
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 136
IS - 5
PB - Cambridge University Press
AB - Truncated models are indirect methods to estimate the size of a hidden population which, in contrast to the capture-recapture method, can be used on a single information source. We estimated the coverage of a tuberculosis screening programme among illicit drug users and homeless persons with a mobile digital X-ray unit between 1 January 2003 and 31 December 2005 in Rotterdam, The Netherlands, using truncated models. The screening programme reached about two-third of the estimated target population at least once annually. The intended coverage (at least two chest X-rays per person per year) was about 23%. We conclude that simple truncated models can be used relatively easily on available single-source routine data to estimate the size of a population of illicit drug users and homeless persons. We assumed that the most likely overall bias in this study would be overestimation and therefore the coverage of the targeted mobile tuberculosis screening programme would be higher.
SN - 0950-2688
AD - Tuberculosis Control Section, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands. vanhestr@ggd.rotterdam.nl
U2 - PMID: 17631692.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105792673
T1 - The impact of operating heavy equipment vehicles on lower back disorders.
AU - Waters T
AU - Genaidy A
AU - Viruet HB
AU - Makola M
Y1 - 2008/05//
N1 - Accession Number: 105792673. Language: English. Entry Date: 20080822. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; systematic review; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Evidence-Based Practice; Pain and Pain Management. Instrumentation: Epidemiological Appraisal Instrument (EAI) (Genaidy et al). NLM UID: 0373220.
KW - Automobile Driving
KW - Industry
KW - Low Back Pain
KW - Neck Pain
KW - Occupational Diseases
KW - Vibration
KW - Confidence Intervals
KW - Construction Industry
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Logistic Regression
KW - Mathematics
KW - Meta Analysis
KW - National Institute for Occupational Safety and Health
KW - Occupational Health
KW - Odds Ratio
KW - Professional Practice, Evidence-Based
KW - PubMed
KW - Relative Risk
KW - Research Methodology -- Evaluation
KW - Scales
KW - Human
SP - 602
EP - 636
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 51
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Literature reviews examining the relationship between heavy equipment vehicle (HEV) operation and the development of musculoskeletal disorders have generally been qualitative in nature and have not employed an evidence-based assessment procedure. This research determines the extent to which whole-body vibration/shock and working postures are associated with lower back and neck disorders among HEV operators, while accounting for individual (i.e. age, gender, prior history of back or neck disorders) and occupational (i.e. material handling, climatic conditions, psychosocial factors) confounders. Published articles were obtained from a search of electronic databases and from bibliographies in the identified articles. A critical appraisal of these articles was conducted using an epidemiological appraisal instrument (Genaidy et al. 2007). The meta-analysis was conducted using statistical techniques employing fixed-effect and random-effect models. Eighteen articles reporting observational studies satisfied the inclusion criteria adopted for this research. The methodological qualities of the published studies ranged from marginal to average. The meta-relative risk was found to be 2.21, indicating that operators exposed to driving HEVs are at more than twice the risk of developing lower back pain in comparison to those not exposed to driving HEVs. Therefore, it seems possible that there is a causal relationship between working as a HEV operator and development of lower back disorders. Prospective cohort studies are urgently needed to confirm the outcomes of this evidence-based methodology (based in part on the meta-analysis) and the biological plausibility should be further explored. The reported findings point to a need for improved ergonomic design of HEVs.
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
U2 - PMID: 18432441.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Han, Beom Seok
AU - Lee, Hakyung
AU - Kim, Cheulkyu
AU - Nam, Ki Taek
AU - Park, KiDae
AU - Choi, Mina
AU - Kim, Sung Jun
AU - Kim, Seung Hee
AU - Jeong, Jayoung
AU - Jang, Dong Deuk
T1 - Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/05//
VL - 46
IS - 5
M3 - Article
SP - 1666
EP - 1673
SN - 02786915
AB - Abstract: 3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400ppm groups. A delayed total estrus cycle length was observed in the 400ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100ppm (18.05mg/kg/day for males and 15.02mg/kg/day for females). [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD contamination
KW - CANCER
KW - FOOD industry
KW - MICE as laboratory animals
KW - CELL motility
KW - EPITHELIUM
KW - 3-monochloropropane-1,2-diol
KW - 3-monochloropropane-1,2-diol ( 3-MCPD )
KW - association for assessment and accreditation of laboratory animal care international ( AAALAC International )
KW - B6C3F1 mice
KW - Korea food and drug administration ( KFDA )
KW - No-observed-adverse-effect level
KW - no-observed-adverse-effect level ( NOAEL )
KW - organization for economic cooperation and development ( OECD )
KW - Toxicity
N1 - Accession Number: 31409559; Cho, Wan-Seob 1 Han, Beom Seok 1 Lee, Hakyung 1 Kim, Cheulkyu 1 Nam, Ki Taek 1 Park, KiDae 1 Choi, Mina 1 Kim, Sung Jun 1 Kim, Seung Hee 1 Jeong, Jayoung 1 Jang, Dong Deuk; Email Address: ddjang@kfda.go.kr; Affiliation: 1: Division of Toxicologic Pathology, Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Korea FDA, 5 Nokbun-dong, Eunpyung–ku, Seoul 122-704, Republic of Korea; Source Info: May2008, Vol. 46 Issue 5, p1666; Subject Term: FOOD contamination; Subject Term: CANCER; Subject Term: FOOD industry; Subject Term: MICE as laboratory animals; Subject Term: CELL motility; Subject Term: EPITHELIUM; Author-Supplied Keyword: 3-monochloropropane-1,2-diol; Author-Supplied Keyword: 3-monochloropropane-1,2-diol ( 3-MCPD ); Author-Supplied Keyword: association for assessment and accreditation of laboratory animal care international ( AAALAC International ); Author-Supplied Keyword: B6C3F1 mice; Author-Supplied Keyword: Korea food and drug administration ( KFDA ); Author-Supplied Keyword: No-observed-adverse-effect level; Author-Supplied Keyword: no-observed-adverse-effect level ( NOAEL ); Author-Supplied Keyword: organization for economic cooperation and development ( OECD ); Author-Supplied Keyword: Toxicity; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.fct.2007.12.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bianca Heemskerk
AU - Ke Liu
AU - Mark. E. Dudley
AU - Laura A. Johnson
AU - Andrew Kaiser
AU - Stephanie Downey
AU - Zhili Zheng
AU - Thomas E. Shelton
AU - Kant Matsuda
AU - Paul F. Robbins
AU - Richard A. Morgan
AU - Steven A. Rosenberg
T1 - Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2.
JO - Human Gene Therapy
JF - Human Gene Therapy
Y1 - 2008/05//
VL - 19
IS - 5
M3 - Article
SP - 496
EP - 510
SN - 10430342
AB - Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) after lymphodepletion mediates regression in 50 of patients with metastatic melanoma. In vivopersistence and telomere length of the transferred cells correlate with antitumor response. In an attempt to prolong the in vivosurvival of the transferred cells, TILs were genetically engineered to produce interleukin (IL)-2. In vitro, these transduced TILs secreted IL-2 while retaining tumor specificity and exhibited prolonged survival after IL-2 withdrawal. In a phase III clinical trial, seven evaluable patients received transduced TILs and one patient experienced a partial response associated with in vivopersistence of IL-2-transduced TILs in circulating lymphocytes. An additional five patients received transduced TILs in conjunction with IL-2 administration. Persistence of IL-2-transduced TILs was observed in three patients, including one partial responder. The transgene DNA as well as vector-derived IL2 mRNA could be detected for 4 months in responding patients. The low response rate in this trial was possibly due to a reduction in telomere length in cells as a result of prolonged in vitroculture. In this study, insertion of the IL-2 gene into antitumor TILs increased their ability to survive after IL-2 withdrawal in vitrobut did not increase their in vivopersistence or clinical effectiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Gene Therapy is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLULAR therapy
KW - MELANOMA
KW - INTERLEUKIN-2
KW - ANTINEOPLASTIC agents
N1 - Accession Number: 33048958; Bianca Heemskerk 1 Ke Liu 1,2 Mark. E. Dudley 1 Laura A. Johnson 1 Andrew Kaiser 1 Stephanie Downey 1 Zhili Zheng 1 Thomas E. Shelton 1 Kant Matsuda 3 Paul F. Robbins 1 Richard A. Morgan 1 Steven A. Rosenberg 1; Affiliation: 1: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. 2: U.S. Food and Drug Administration, Rockville, MD 20852. 3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.; Source Info: May2008, Vol. 19 Issue 5, p496; Subject Term: CELLULAR therapy; Subject Term: MELANOMA; Subject Term: INTERLEUKIN-2; Subject Term: ANTINEOPLASTIC agents; Number of Pages: 15p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jeffrey S. Smith
AU - Zhili Xu
AU - Jie Tian
AU - Susan C. Stevenson
AU - Andrew P. Byrnes
T1 - Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver.
JO - Human Gene Therapy
JF - Human Gene Therapy
Y1 - 2008/05//
VL - 19
IS - 5
M3 - Article
SP - 547
EP - 554
SN - 10430342
AB - When adenovirus (Ad) vectors are injected intravenously they are rapidly taken up by Kupffer cells (KCs) in the liver. This results in massive KC necrosis within minutes, followed by a more gradual disappearance of KCs from the liver. It is not known how KCs recognize Ad, or why Ad kills KCs. We used a variety of mutated and fiber-pseudotyped Ad vectors to evaluate how capsid proteins influence Ad uptake by KCs and to define the viral proteins that are involved in the destruction of KCs. We found that depletion of KCs from the liver was partially dependent on interactions between Ad and integrins, but was independent of the coxsackievirus and Ad receptor. The Ad5 fiber shaft was proven to be a particularly important contributory factor, because vectors with the shorter Ad35 shaft were not as effective at depleting KCs. In contrast, the fiber head played no discernible role. Variations in the ability of Ad vectors to deplete KCs could not be explained by differences in the amount of Ad that reached KCs, because all mutant Ads were accumulated by KCs at similar levels. Interestingly, we found that the Ad mutant ts1 did not cause KC death; this virus is known to bind and enter cells normally, but the capsid is unable to disassemble or lyse membranes. We conclude that Ad vectors kill KCs at a postbinding step and that this cell death can be mitigated if downstream events in viral entry are blocked. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Gene Therapy is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - KUPFFER cells
KW - LIVER
KW - MICE
N1 - Accession Number: 33048950; Jeffrey S. Smith 1 Zhili Xu 1 Jie Tian 1 Susan C. Stevenson 2 Andrew P. Byrnes 1; Affiliation: 1: Division of Cellular and Gene Therapies, Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, MD 20892. 2: Department of Diabetes and Metabolism, Novartis Institutes of Biomedical Research, Cambridge, MA 02139.; Source Info: May2008, Vol. 19 Issue 5, p547; Subject Term: ADENOVIRUSES; Subject Term: KUPFFER cells; Subject Term: LIVER; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de la Rie, Simone
AU - Noordenbos, Greta
AU - Donker, Marianne
AU - van Furth, Eric
T1 - The quality of treatment of eating disorders: A comparison of the therapists' and the patients' perspective.
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
Y1 - 2008/05//
VL - 41
IS - 4
M3 - Article
SP - 307
EP - 317
PB - John Wiley & Sons, Inc.
SN - 02763478
AB - Objective: The aims of this study were to investigate the quality of treatment of eating disorders (EDs) from the therapists' and patients' perspective and to compare their views. Method: The Questionnaire for Eating Problems and Treatment (QEPT) was administered to 73 therapists working with patients with ED, to 156 current ED and 148 former ED patients. The QEPT addresses the quality of treatment of EDs. ED diagnosis was assessed by the Eating Disorder Examination Questionnaire. Answers were analyzed quantitatively and qualitatively. Results: Both therapists and patients most often mentioned focus of treatment, therapeutic alliance, and communicational skills as important aspects of the quality of treatment. However, they valued similar topics differently. Therapists valued the focus on ED symptoms and behavioral change more highly, whereas patients underscored the importance of the therapeutic relationship and addressing underlying problems. Most therapists work from a cognitive behavioral orientation, but protocol-based treatment was not found important. Conclusion: There is an avid need for dissemination of evidence-based treatment. Therapists' and patients' views supplement current evidence-based knowledge on treatment quality of EDs. Optimal treatment of EDs will be facilitated when these three bodies of knowledge—the available evidence and the therapists' and patients' views—are integrated. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Eating Disorders is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EATING disorders
KW - APPETITE disorders
KW - INTERPERSONAL relations
KW - PATHOLOGICAL psychology
KW - COGNITIVE therapy
KW - PSYCHOTHERAPY
KW - eating disorders
KW - patients'
KW - perspective
KW - quality
KW - therapists'
KW - treatment
N1 - Accession Number: 31630623; de la Rie, Simone 1; Email Address: s.delarie@centrumeetstoornissen.nl Noordenbos, Greta 2 Donker, Marianne 3,4 van Furth, Eric 1,5; Affiliation: 1: Centre for Eating Disorders Ursula, Leidschendam, The Netherlands 2: Department of Psychology, Leiden University, Leiden, The Netherlands 3: Erasmus MC, Department of Public Health, University Medical Centre, Rotterdam, The Netherlands 4: Municipal Public Health Service of Rotterdam-Rijnmond, Rotterdam, The Netherlands 5: Department of Psychiatry, Leiden University, Leiden, The Netherlands; Source Info: May2008, Vol. 41 Issue 4, p307; Subject Term: EATING disorders; Subject Term: APPETITE disorders; Subject Term: INTERPERSONAL relations; Subject Term: PATHOLOGICAL psychology; Subject Term: COGNITIVE therapy; Subject Term: PSYCHOTHERAPY; Author-Supplied Keyword: eating disorders; Author-Supplied Keyword: patients'; Author-Supplied Keyword: perspective; Author-Supplied Keyword: quality; Author-Supplied Keyword: therapists'; Author-Supplied Keyword: treatment; Number of Pages: 11p; Illustrations: 9 Charts; Document Type: Article
L3 - 10.1002/eat.20494
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maeda, Setsuo
AU - Mansfield, Neil J.
AU - Shibata, Nobuyuki
T1 - Evaluation of subjective responses to whole-body vibration exposure: Effect of frequency content
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/05//
VL - 38
IS - 5/6
M3 - Article
SP - 509
EP - 515
SN - 01698141
AB - Abstract: The relationship between the subjective ride comfort in a vehicle seat and whole-body vibration can be modeled using frequency weightings and rms averaging as specified in ISO 2631-1. If two vibrating environments have the same frequency-weighted rms acceleration value using this method, it is assumed that the two environments would have the same degree of discomfort. In recent years, it has been found that when subjects are exposed to random whole-body vibration, even with the same frequency-weighted rms acceleration signals according to the ISO 2631-1 standard which consists of different frequency spectra will elicit different degree of comfort. From the viewpoint of this result, it is doubtful whether frequency-weighting based on ISO 2631-1 is appropriate for such vibrations. In this paper, the alternative approach which Miwa''s proposed VG method modified was examined. The following conclusion was suggested: VGt value which was obtained by the alternative approach seems to be appropriate from random vibrations which have same frequency-weighted rms acceleration with different frequency components. The alternative approach based on the VG method has wider applicability but requires more researches. Relevance to industry: Few researchers have demonstrated the problem of the frequency-weighting method of the ISO 2631-1 standard. This may have implications to current used ISO frequency-weighting method for evaluating the comfort on the vehicle seats. Therefore, comfortable evaluation of the vehicle seats vibration by the amount of frequency-weighted rms acceleration values obtained by the ISO 2631-1 standard takes cautions. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Automobile industry
KW - Research -- Methodology
KW - Engineering design
KW - Automobile seats
KW - Frequency-weighting method
KW - ISO 2631-1 standard
KW - Subjective scaling
KW - VG
KW - Vibration greatness
KW - Whole-body vibration
N1 - Accession Number: 31918885; Maeda, Setsuo 1; Email Address: maedas@h.jniosh.go.jp; Mansfield, Neil J. 2; Shibata, Nobuyuki 1; Affiliations: 1: Measurement and Control of Work Environment Research Group, Japan National Institute of Occupational Safety and Health (JNIOSH), Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Human Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK; Issue Info: May2008, Vol. 38 Issue 5/6, p509; Thesaurus Term: Automobile industry; Subject Term: Research -- Methodology; Subject Term: Engineering design; Subject Term: Automobile seats; Author-Supplied Keyword: Frequency-weighting method; Author-Supplied Keyword: ISO 2631-1 standard; Author-Supplied Keyword: Subjective scaling; Author-Supplied Keyword: VG; Author-Supplied Keyword: Vibration greatness; Author-Supplied Keyword: Whole-body vibration; NAICS/Industry Codes: 336110 Automobile and light-duty motor vehicle manufacturing; NAICS/Industry Codes: 336111 Automobile Manufacturing; NAICS/Industry Codes: 336211 Motor Vehicle Body Manufacturing; NAICS/Industry Codes: 415110 New and used automobile and light-duty truck merchant wholesalers; NAICS/Industry Codes: 441110 New Car Dealers; NAICS/Industry Codes: 423110 Automobile and Other Motor Vehicle Merchant Wholesalers; NAICS/Industry Codes: 336360 Motor Vehicle Seating and Interior Trim Manufacturing; NAICS/Industry Codes: 541330 Engineering Services; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ergon.2007.08.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Donald P. Tuchman
AU - Jon C. Volkwein
AU - Robert P. Vinson
T1 - Implementing infrared determination of quartz particulates on novel filters for a prototype dust monitor.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/05//
VL - 10
IS - 5
M3 - Article
SP - 671
EP - 678
SN - 14640325
AB - Research by the National Institute for Occupational Safety and Health (NIOSH) has pursued quartz analysis for the specialized filter assemblies of a new worker-wearable personal dust monitor (PDM). The PDM is a real-time instrument utilizing a tapered element oscillating microbalance (TEOM®). Standard fiberglass TEOM filters cannot accommodate the desired P-7 infrared analytical method used by the Mine Safety and Health Administration (MSHA). Novel filter materials were tested with the objective of demonstrating this type of analysis. Low temperature ashing and spectrometric examination were employed, revealing that nylon fiber candidate filters left minimal residual ash and produced no significant spectral interference. Avoiding titanium dioxide in all filter materials proved to be a key requirement. Fine quartz particulates were collected on prototype filters in a Marple chamber, either open-faced or through PDMs during test runs. The filters were then subjected to MSHA P-7 analysis and the spectrometrically based analytical results for quartz mass were compared to reference measurements. Also, PDM instrumental mass readings were compared to filter gravimetric measurements. Results suggest that the P-7 method is adaptable to variations in filter materials and that quartz dust analysis by the P-7 method when utilizing the new ashable PDM filters can have accuracy and precision within 10% and 4%, respectively. This is within the declared 13% accuracy and 7–10% precision of the P-7 method itself. Instrument mass readings had modest positive bias but met NIOSH accuracy criteria. Continued work with specialized PDM filters is merited, as they are a new type of TEOM sample amenable to ashing analysis of particulates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mine safety
KW - Infrared detectors
KW - Titanium dioxide
KW - Oxide minerals
N1 - Accession Number: 32932970; Donald P. Tuchman 1; Jon C. Volkwein 1; Robert P. Vinson 1; Affiliations: 1: US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory626 Cochrans Mill Road Pittsburgh, PA USA; Issue Info: May2008, Vol. 10 Issue 5, p671; Thesaurus Term: Mine safety; Subject Term: Infrared detectors; Subject Term: Titanium dioxide; Subject Term: Oxide minerals; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Choi, B. C. K.
AU - McQueen, D. V.
AU - Puska, P.
AU - Douglas, K. A.
AU - Ackland, M.
AU - Campostrini, S.
AU - Barceló, A.
AU - Stachenko, S.
AU - Mokdad, A. H.
AU - Granero, R.
AU - Corber, S. J.
AU - Valleron, A.-J.
AU - Skinner, H. A.
AU - Potemkina, A.
AU - Lindner, M. C.
AU - Zakus, D.
AU - de Salazar, L. M.
AU - Pak, A. W. P.
AU - Ansari, Z.
AU - Zevallos, J. C.
T1 - Enhancing global capacity in the surveillance, prevention, and control of chronic diseases: seven themes to consider and build upon.
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
Y1 - 2008/05//
VL - 62
IS - 5
M3 - Article
SP - 391
EP - 397
SN - 0143005X
AB - Background: Chronic diseases are now a major health problem in developing countries as well as in the developed world. Although chronic diseases cannot be communicated from person to person, their risk factors (for example, smoking, inactivity, dietary habits) are readily transferred around the world. With increasing human progress and technological advance, the pandemic of chronic diseases will become an even bigger threat to global health. Methods: Based on our experiences and publications as well as review of the literature, we contribute ideas and working examples that might help enhance global capacity in the surveillance of chronic diseases and their prevention and control. Innovative ideas and solutions were actively sought. Results: Ideas and working examples to help enhance global capacity were grouped under seven themes, concisely summarised by the acronym "SCIENCE": Strategy, Collaboration, Information, Education, Novelty, Communication and Evaluation. Conclusion: Building a basis for action using the seven themes articulated, especially by incorporating innovative ideas, we presented here, can help enhance global capacity in chronic disease surveillance, prevention and control. Informed initiatives can help achieve the new World Health Organization global goal of reducing chronic disease death rates by 2% annually, generate new ideas for effective interventions and ultimately bring global chronic diseases under greater control. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Epidemiology & Community Health is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC diseases
KW - PREVENTION
KW - SMOKING
KW - HYPOKINESIA
KW - WORLD health
KW - DEVELOPING countries
N1 - Accession Number: 31958802; Choi, B. C. K. 1,2,3; Email Address: Bernard_Choi@phac-aspc.gc.ca McQueen, D. V. 4 Puska, P. 5 Douglas, K. A. Ackland, M. 6 Campostrini, S. 7 Barceló, A. 8 Stachenko, S. 9 Mokdad, A. H. 10 Granero, R. 11 Corber, S. J. 12 Valleron, A.-J. 13 Skinner, H. A. 14 Potemkina, A. 15 Lindner, M. C. 16 Zakus, D. 17 de Salazar, L. M. 18 Pak, A. W. P. 19 Ansari, Z. Zevallos, J. C. 20; Affiliation: 1: Centre tor Chronic Disease Prevention and Control, Public Health Agency ot Canada (PHAC), Government of Canada, Ottawa, Ontario 2: Diagnosis and Intervention of Cardiovascular and Chronic Disease Risk Factors in the Population, National Federation of Coffee Growers of Colombia, Bogotá, Colombia 3: WHO Collaborating Centre for Electronic Surveillance of Diseases, Paris 4: Department of Public Health Sciences, University of Toronto, Toronto, Ontario 5: Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada 6: National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Centers for Disease Control and Prevention (CDC), US Department of Health and Human Services (DHSS), Atlanta, GA, USA 7: National Public Health Institute (KTL), Helsinki, Finland 8: Communicable Disease Control Unit, Public Health Branch, Victorian Department of Human Services, Melbourne, Australia 9: Department of Statistics, University of Venice, Venice, Italy 10: Disease Prevention and Control, Pan American Health Organization (PAHO), Washington DC, USA 11: Public Health Agency of Canada, Government of Canada, Ottawa, Ontario, Canada 12: Behavioral Surveillance Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Coordinating Center for Health Promotion, Centers for Disease Control and Prevention (CDC), US Department of Health and Human Services (DHSS), Atlanta, GA, USA 13: ASCARDIO and Ministry of Health and Social Development; Americas' Network for Chronic Disease Surveillance (AMNET), Barquisimeto, Venezuela 14: Health Sciences, Simon Fraser University, Burnaby, BC, Canada 15: Doctoral School of Public Health and Information Science, Université Pierre et Marie Curie, Paris, France 16: Faculty of Health, York University, Toronto, Ontario, Canada 17: State Research Centre for Preventive Medicine, Ministry of Health and Social Development of Russian Federation, Moscow, Russia 18: Department of Clinical Laboratory, Clinical Hospital, Faculty of Medicine, Universidad de Ia República Oriental del Uruguay; Ministry of Public Health, Montevideo, Uruguay 19: Centre for International Health; Department of Public Health Sciences and Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 20: Center for Evaluation of Public Health, Policies, Programs and Technologies, CEDETES; School of Public Health, Universidad del Valle, Cali, Colombia; Source Info: May2008, Vol. 62 Issue 5, p391; Subject Term: CHRONIC diseases; Subject Term: PREVENTION; Subject Term: SMOKING; Subject Term: HYPOKINESIA; Subject Term: WORLD health; Subject Term: DEVELOPING countries; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1136/jech.2007.060368
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31958802&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tong-Jen Fu
AU - Reineke, Karl F.
AU - Chirtel, Stuart
AU - VanPelt, Olif M.
T1 - Factors Influencing the Growth of Salmonella during Sprouting of Naturally Contaminated Alfalfa Seeds.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/05//
VL - 71
IS - 5
M3 - Article
SP - 888
EP - 896
SN - 0362028X
AB - In this study, the factors that affect Salmonella growth during sprouting of naturally contaminated alfalfa seeds associated with two previous outbreaks of salmonellosis were examined. A minidrum sprouter equipped with automatic irrigation and rotation systems was built to allow sprouting to be conducted under conditions similar to those used commercially. The growth of Salmonella during sprouting in the minidrum was compared with that observed in sprouts grown in glass jars under conditions commonly used at home. The level of Salmonella increased by as much as 4 log units after 48 h of sprouting in jars but remained constant during the entire sprouting period in the minidrum. The effect of temperature and irrigation frequency on Salmonella growth was examined. Increasing the sprouting temperature from 20 to 30°C increased the Salmonella counts by as much as 2 log units on sprouts grown both in the minidrum and in the glass jars. Decreasing the irrigation frequency from every 20 min to every 2 h during sprouting in the minidrum or from every 4 h to every 24 h during sprouting in the glass jars resulted in an approximately 2-log increase in Salmonella counts. The levels of total aerobic mesophilic bacteria, coliforms, and Salmonella in spent irrigation water closely reflected those found in sprouts, confirming that monitoring of spent irrigation water is a good way to monitor pathogen levels during sprouting. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Bacterial growth
KW - SEEDS
KW - Alfalfa
KW - Sprouts
KW - Salmonella diseases
N1 - Accession Number: 32144859; Tong-Jen Fu 1; Email Address: tong.fu@fda.hhs.gov; Reineke, Karl F. 1; Chirtel, Stuart 2; VanPelt, Olif M. 3; Affiliations: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501; 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland 20740, USA; 3: Illinois Institute of Technology, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501; Issue Info: May2008, Vol. 71 Issue 5, p888; Thesaurus Term: Salmonella; Thesaurus Term: Bacterial growth; Thesaurus Term: SEEDS; Subject Term: Alfalfa; Subject Term: Sprouts; Subject Term: Salmonella diseases; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111940 Hay Farming; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 2 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zidan, A. S.
AU - Sammour, O. A.
AU - Hammad, M. A.
AU - Megrab, N. A.
AU - Habib, M. J.
AU - Khan, M. A.
T1 - Process analytical technology: Non-destructive assessment of anastrozole entrapment within PLGA microparticles by near infrared spectroscopy and chemical imaging.
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
Y1 - 2008/05//
VL - 25
IS - 3
M3 - Article
SP - 145
EP - 153
PB - Taylor & Francis Ltd
SN - 02652048
AB - The objective of this study was to evaluate near-infrared (NIR) spectroscopy and imaging as approaches to assess anastrozole entrapment within PLGA microparticles. By varying the polymer concentration, three batches containing the same amount of the drug were prepared. The spectral features that allow NIR drug quantitation were evaluated and compared with a best fit line algorithm. Actual entrapment efficiencies (EEF) determined via a destructive method were used for construction of calibration models using partial least square regression (PLS) or the algorithm. On the other hand, a chemical imaging system based on array detector technology was used to rapidly collect high contrast NIR images of the formulated microparticles. A quantitative measure of anastrozole entrapped was determined by calculating the percentage standard deviation of the distribution of pixel intensities in the PLS score images and histograms. Concerning conventional NIR analysis, both methods were equivalent for the prediction of EEF over the range of polymer levels studied. Correlation coefficients of more than 0.992 were obtained for either the calibration or prediction of EEF by the two methods; 0.392% and 0.374% were the standard errors of calibration and prediction (SEC and SEP) obtained for the prediction of EEF using the fit line, respectively, whereas the prediction of the EEF by the partial least square regression showed a SEC of 0.195% and SEP of 0.179%. As a result, the spectral best fit algorithm method compared favourably to the multivariate PLS method, but was easier to develop. In contrast, NIR spectral imaging was capable of clearly differentiating the three batches, both qualitatively and quantitatively. The percentage standard deviation increased progressively by increasing the ratio of drug-to-polymer concentrations. In conclusion, both NIR approaches were capable of accurate assessment of drug entrapment within microparticles. In addition, the NIR spectral imaging system provides a rapid approach for acquiring spatial and spectral information on microparticles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Microencapsulation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEAR infrared spectroscopy
KW - SPECTRUM analysis
KW - POLYMERS
KW - CALIBRATION
KW - SCANNING systems
KW - anastrozole
KW - Microencapsulation
KW - near infrared
KW - NIR imaging
KW - PLGA
N1 - Accession Number: 31499234; Zidan, A. S. 1,2,3 Sammour, O. A. 2 Hammad, M. A. 2 Megrab, N. A. 2 Habib, M. J. 3 Khan, M. A. 1; Email Address: Mansoor.Khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Food and Drug Administration, Maryland, USA. 2: Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. 3: School of Pharmacy, Howard University, Washington DC, USA.; Source Info: May2008, Vol. 25 Issue 3, p145; Subject Term: NEAR infrared spectroscopy; Subject Term: SPECTRUM analysis; Subject Term: POLYMERS; Subject Term: CALIBRATION; Subject Term: SCANNING systems; Author-Supplied Keyword: anastrozole; Author-Supplied Keyword: Microencapsulation; Author-Supplied Keyword: near infrared; Author-Supplied Keyword: NIR imaging; Author-Supplied Keyword: PLGA; Number of Pages: 9p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/02652040601034963
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Silva-Adaya, Daniela
AU - Pérez-De La Cruz, Verónica
AU - Herrera-Mundo, María Nieves
AU - Mendoza-Macedo, Karina
AU - Villeda-Hernández, Juana
AU - Binienda, Zbigniew
AU - Ali, Syed F.
AU - Santamaría, Abel
T1 - Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects ofl-carnitine.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2008/05//
VL - 105
IS - 3
M3 - Article
SP - 677
EP - 689
PB - Wiley-Blackwell
SN - 00223042
AB - Excitotoxicity and disrupted energy metabolism are major events leading to nerve cell death in neurodegenerative disorders. These cooperative pathways share one common aspect: triggering of oxidative stress by free radical formation. In this work, we evaluated the effects of the antioxidant and energy precursor, levocarnitine (l-CAR), on the oxidative damage and the behavioral, morphological, and neurochemical alterations produced in nerve tissue by the excitotoxin and free radical precursor, quinolinic acid (2,3-pyrindin dicarboxylic acid; QUIN), and the mitochondrial toxin, 3-nitropropionic acid (3-NP). Oxidative damage was assessed by the estimation of reactive oxygen species formation, lipid peroxidation, and mitochondrial dysfunction in synaptosomal fractions. Behavioral, morphological, and neurochemical alterations were evaluated as markers of neurotoxicity in animals systemically administered withl-CAR, chronically injected with 3-NP and/or intrastriatally infused with QUIN. At micromolar concentrations,l-CAR reduced the three markers of oxidative stress stimulated by both toxins alone or in combination.l-CAR also prevented the rotation behavior evoked by QUIN and the hypokinetic pattern induced by 3-NP in rats. Morphological alterations produced by both toxins (increased striatal glial fibrillary acidic protein-immunoreactivity for QUIN and enhanced neuronal damage in different brain regions for 3-NP) were reduced byl-CAR. In addition,l-CAR prevented the synergistic action of 3-NP and QUIN to increase motor asymmetry and depleted striatal GABA levels. Our results suggest that the protective properties ofl-CAR in the neurotoxic models tested are mostly mediated by its characteristics as an antioxidant agent. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENERGY metabolism
KW - CELL death
KW - NEURODEGENERATION
KW - OXIDATIVE stress
KW - PEROXIDATION
KW - 3-nitropropionic acid
KW - energy metabolism deficit
KW - excitotoxicity
KW - L-carnitine
KW - neuroprotection
KW - quinolinic acid
N1 - Accession Number: 31688073; Silva-Adaya, Daniela 1 Pérez-De La Cruz, Verónica 1 Herrera-Mundo, María Nieves 1 Mendoza-Macedo, Karina 1 Villeda-Hernández, Juana 2 Binienda, Zbigniew 3 Ali, Syed F. 3 Santamaría, Abel 1,3; Email Address: absada@yahoo.com; Affiliation: 1: Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México, Mexico 2: Laboratorio de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México, Mexico 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas, USA; Source Info: May2008, Vol. 105 Issue 3, p677; Subject Term: ENERGY metabolism; Subject Term: CELL death; Subject Term: NEURODEGENERATION; Subject Term: OXIDATIVE stress; Subject Term: PEROXIDATION; Author-Supplied Keyword: 3-nitropropionic acid; Author-Supplied Keyword: energy metabolism deficit; Author-Supplied Keyword: excitotoxicity; Author-Supplied Keyword: L-carnitine; Author-Supplied Keyword: neuroprotection; Author-Supplied Keyword: quinolinic acid; Number of Pages: 13p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1111/j.1471-4159.2007.05174.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Arthur T.
AU - Koh, Frank C.
AU - Jamshidi, Shaya
AU - Rehak, Timothy E.
T1 - Human Subject Testing of Leakage in a Loose-Fitting PAPR.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/05//
VL - 5
IS - 5
M3 - Article
SP - 325
EP - 329
PB - Taylor & Francis Ltd
SN - 15459624
AB - Leakage from loose-fitting PAPRs (powered air-purifying respirators) can compromise the safety of wearers. The Martindale Centurion MAX multifunction PAPR is a loose-fitting PAPR that also incorporates head, eye, and ear protection. This respirator is used in mines where coal dust usually is controlled by ventilation systems. Should the respirator be depended on for significant respiratory protection? Ten human volunteers were asked to wear the Centurion MAX inside a fog-filled chamber. Their inhalation flow rates were measured with small pitot-tube flowmeters held inside their mouths. They were video imaged while they breathed deeply, and the points at which the fog reached their mouths were determined. Results showed that an average of 1.1 L could be inhaled before contaminated air reached the mouth. As long as the blower purges contamination from inside the face piece during exhalation, the 1.1 L acts as a buffer against contaminants leaked due to overbreathing of blower flow rate. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Artificial respiration
KW - Dampness in buildings
KW - Air conditioning
KW - Contamination (Psychology)
KW - Buildings -- Aerodynamics
KW - dead volume
KW - protection
KW - protection factor
KW - respirator
N1 - Accession Number: 75127823; Johnson, Arthur T. 1; Koh, Frank C. 1; Jamshidi, Shaya 1; Rehak, Timothy E. 2; Affiliations: 1: Fischell Department of Bioengineering, University of Maryland, College Park, Maryland; 2: National Personal Protection Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; Issue Info: May2008, Vol. 5 Issue 5, p325; Thesaurus Term: Artificial respiration; Thesaurus Term: Dampness in buildings; Thesaurus Term: Air conditioning; Subject Term: Contamination (Psychology); Subject Term: Buildings -- Aerodynamics; Author-Supplied Keyword: dead volume; Author-Supplied Keyword: protection; Author-Supplied Keyword: protection factor; Author-Supplied Keyword: respirator; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 5p; Document Type: Article
L3 - 10.1080/15459620801996819
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Trout, Douglas
AU - Zumwalde, Ralph D.
AU - Kuempel, Eileen
AU - Geraci, Charles L.
AU - Castranova, Vincent
AU - Mundt, Diane J.
AU - Halperin, William E.
T1 - Options for Occupational Health Surveillance of Workers Potentially Exposed to Engineered Nanoparticles: State of the Science.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/05//
VL - 50
IS - 5
M3 - Article
SP - 517
EP - 526
SN - 10762752
AB - The article reports on the study of the occupational health of workers who are exposed to engineered nanoparticles. The study aims to identify occupational health surveillance options of workers who are exposed to engineered nanoparticles. It is also made to help health authorities, employers and worker representatives in facing occupational health. It shows that occupational health surveillance options were rated from no action to nanotechnology workers to an approach that includes documentation of engineered nanoparticles and workers' medical testing.
KW - INDUSTRIAL hygiene
KW - PUBLIC health surveillance
KW - NANOPARTICLES
KW - OCCUPATIONAL health services
KW - NANOSTRUCTURED materials
KW - NANOTECHNOLOGY
KW - DIAGNOSIS
KW - ENVIRONMENTAL health
N1 - Accession Number: 32137763; Schulte, Paul A. 1; Email Address: pas4@cdc.gov Trout, Douglas 1 Zumwalde, Ralph D. 1 Kuempel, Eileen 1 Geraci, Charles L. 1 Castranova, Vincent 1 Mundt, Diane J. 2 Halperin, William E. 3; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 2: ENVIRON International Corporation, Amherst, Mass 3: University of medicine and Density of New Jersey, NJ; Source Info: May2008, Vol. 50 Issue 5, p517; Subject Term: INDUSTRIAL hygiene; Subject Term: PUBLIC health surveillance; Subject Term: NANOPARTICLES; Subject Term: OCCUPATIONAL health services; Subject Term: NANOSTRUCTURED materials; Subject Term: NANOTECHNOLOGY; Subject Term: DIAGNOSIS; Subject Term: ENVIRONMENTAL health; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 10p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1097/JOM.0b013e31816515f7
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DP - EBSCOhost
DB - aph
ER -
TY - CASE
AU - Weinmann, Sheila
AU - Vollmer, William M.
AU - Breen, Victor
AU - Heumann, Michael
AU - Hnizdo, Eva
AU - Villnave, Jacqueline
AU - Doney, Brent
AU - Graziani, Monica
AU - McBurnie, Mary Ann
AU - Buist, A. Sonia
T1 - COPD and Occupational Exposures: A Case-Control Study.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/05//
VL - 50
IS - 5
M3 - Case Study
SP - 561
EP - 569
SN - 10762752
AB - The article presents a case study on occupational exposures and its connection with chronic obstructive pulmonary disease (COPD) on respondents aged 45 years old and above. The results suggest that occupational exposures most strongly linked with COPD were diesel exhaust, irritant gases and vapors, mineral dust and metal dust.
KW - OBSTRUCTIVE lung diseases
KW - DUST
KW - THRESHOLD limit values (Industrial toxicology)
KW - DIESEL motor exhaust gas
KW - VAPORS
N1 - Accession Number: 32137768; Weinmann, Sheila 1; Email Address: sheila.weinmann@kpchr.org Vollmer, William M. 1 Breen, Victor 1 Heumann, Michael 2 Hnizdo, Eva 3 Villnave, Jacqueline 1 Doney, Brent 3 Graziani, Monica 3 McBurnie, Mary Ann 1 Buist, A. Sonia 4; Affiliation: 1: Center for Health Researhc, Kaiser Permanente Northwest, Portland, Oreg 2: Oregon Department of Human Services, Portland, Oreg 3: National Institute of Occupational Safety and Health, Morgantown, WV 4: Department of Pulmonary & Critical Care Medicine, Oregon Health and Science University, Portland, Oreg; Source Info: May2008, Vol. 50 Issue 5, p561; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: DUST; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: DIESEL motor exhaust gas; Subject Term: VAPORS; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Case Study
L3 - 10.1097/JOM.0b013e3181651556
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105814360
T1 - Options for occupational health surveillance of workers potentially exposed to engineered nanoparticles: state of the science.
AU - Schulte PA
AU - Trout D
AU - Zumwalde RD
AU - Kuempel E
AU - Geraci CL
AU - Castranova V
AU - Mundt DJ
AU - Mundt KA
AU - Halperin WE
Y1 - 2008/05//
N1 - Accession Number: 105814360. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 9504688.
KW - Disease Surveillance
KW - Nanomedicine
KW - Occupational Exposure
KW - Occupational Hazards
KW - Occupational Safety
KW - Data Collection
KW - Occupational Diseases -- Diagnosis
KW - Human
SP - 517
EP - 526
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 50
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Health authorities, employers, and worker representatives are increasingly faced with making decisions about occupational health surveillance of workers potentially exposed to engineered nanoparticles. This article was developed to identify options that can be considered. METHODS: The published scientific literature on health effects from engineered and incidental nanoparticles and the principles of occupational health surveillance were reviewed to describe possible options and the evidence base for them. RESULTS: Various options for occupational health surveillance were identified. The options ranged from no action targeted to nanotechnology workers to an approach that includes documentation of the presence of engineered nanoparticles, identification of potentially exposed workers, and general and targeted medical testing. CONCLUSIONS: Although the first priority should be to implement appropriate primary preventive measures, additional efforts to monitor employee health may be warranted. Continued research is needed, and the collection of such information for exposure registries may be useful for future epidemiologic studies.
SN - 1076-2752
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS-C14, Cincinnati, OH 45226-1998; pas4@cdc.gov
U2 - PMID: 18469620.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cunningham, W. C.
AU - Anderson, D. L.
AU - Lamont, W. H.
AU - South, P. K.
AU - Rury, M. A.
AU - Beachley, G. M.
AU - Ondov, J. M.
T1 - Development of a transportable system for radionuclide analysis.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2008/05//
VL - 276
IS - 2
M3 - Article
SP - 317
EP - 322
SN - 02365731
AB - Transportable radioanalytical systems were assembled and tested for quantitative determination of γ-emitting radionuclides and screening of β-emitting radionuclides. Standard operating procedures (SOPs), including instructions for assembly, disassembly, operation, sample collection and analysis, and all other procedures needed, were developed. Foods, as well as National Institute of Standards and Technology, International Atomic Energy Agency, and in-house Reference Materials were analyzed. An SOP for γ-emitting radionuclides was successfully tested at 3 locations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOISOTOPES
KW - ISOTOPES
KW - NUCLEAR engineering
KW - RADIOCHEMISTRY
KW - RADIOACTIVE substances
N1 - Accession Number: 31870594; Cunningham, W. C. 1 Anderson, D. L. 1; Email Address: david.anderson@fda.hhs.gov Lamont, W. H. 1 South, P. K. 2 Rury, M. A. 3 Beachley, G. M. 3 Ondov, J. M. 3; Affiliation: 1: Elemental Research Branch (HFS-338), U. S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA. 2: Regulatory Policy Branch (HFS-306), U. S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA. 3: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.; Source Info: May2008, Vol. 276 Issue 2, p317; Subject Term: RADIOISOTOPES; Subject Term: ISOTOPES; Subject Term: NUCLEAR engineering; Subject Term: RADIOCHEMISTRY; Subject Term: RADIOACTIVE substances; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 6p; Illustrations: 2 Black and White Photographs, 1 Graph; Document Type: Article
L3 - 10.1007/s10967-008-0505-1
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Inn, K. G. W.
AU - Hall, E.
AU - Woodward, IV, J. T.
AU - Stewart, B.
AU - Pollanen, R.
AU - L. Selvig
AU - Turner, S.
AU - Outola, I.
AU - Nour, S.
AU - Kurosaki, H.
AU - LaRosa, J.
AU - Schultz, M.
AU - Lin, Z.
AU - Yu, Z.
AU - McMahon, C.
T1 - Use of thin collodion films to prevent recoil-ion contamination of alpha-spectrometry detectors.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2008/05//
VL - 276
IS - 2
M3 - Article
SP - 385
EP - 390
SN - 02365731
AB - Recoil ions from alpha-particle emission can contaminate surface-barrier detection systems. This contamination results in increased measurement uncertainty, and may require the replacement of expensive detectors. Disposable thin Collodion films are easily prepared and effectively retard the recoil ions when either directly applied to the surface of alpha-sources or as catcher foils between the source and the detector. The thin films are particularly effective for relatively low-level sources, but can sustain structural damage when exposed to high levels of recoil ions (tens of thousands per second) over extended periods of time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IONS
KW - COLLODION
KW - PHYSICS instruments
KW - DETECTORS
KW - ALPHA ray spectrometry
N1 - Accession Number: 31870615; Inn, K. G. W. 1; Email Address: kenneth.inn@nist.gov Hall, E. 2 Woodward, IV, J. T. 1 Stewart, B. 3 Pollanen, R. 4 L. Selvig 5 Turner, S. 1 Outola, I. 1 Nour, S. 1 Kurosaki, H. 1 LaRosa, J. 1 Schultz, M. 6 Lin, Z. 7 Yu, Z. 7 McMahon, C. 8; Affiliation: 1: National Institute of Standards and Technology, Gaithersburg, MD 20899-8462, USA. 2: University of Rochester, Rochester, NY, USA. 3: Carlsbad Environmental Research and Monitoring Center, Carlsbad, NM, USA. 4: Radiation and Nuclear Safety Authority (STUK), Helsinki, Finland. 5: Centennial High School, Boise, ID, USA. 6: University of Iowa, Iowa City, IA, USA. 7: U.S. Food and Drug Administration-WEAC, Winchester, MA, USA. 8: Radiological Protection Institute of Ireland, Dublin, Ireland.; Source Info: May2008, Vol. 276 Issue 2, p385; Subject Term: IONS; Subject Term: COLLODION; Subject Term: PHYSICS instruments; Subject Term: DETECTORS; Subject Term: ALPHA ray spectrometry; Number of Pages: 6p; Illustrations: 3 Black and White Photographs, 4 Graphs; Document Type: Article
L3 - 10.1007/s10967-008-0516-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clark Burton, Nancy
AU - Adhikari, Atin
AU - Iossifova, Yulia
AU - Grinshpun, Sergey A.
AU - Reponen, Tiina
T1 - Effect of Gaseous Chlorine Dioxide on Indoor Microbial Contaminants.
JO - Journal of the Air & Waste Management Association (Air & Waste Management Association)
JF - Journal of the Air & Waste Management Association (Air & Waste Management Association)
Y1 - 2008/05//
VL - 58
IS - 5
M3 - Article
SP - 647
EP - 656
PB - Air & Waste Management Association
SN - 10962247
AB - Traditional and modern techniques for bioaerosol enumeration were used to evaluate the relative efficiency of gaseous chlorine dioxide (ClO2) in reducing the indoor microbial contamination under field and laboratory conditions. The field study was performed in a highly microbially contaminated house, which had had an undetected roof leak for an extended period of time and exhibited large areas of visible microbial growth. Air concentrations of culturable fungi and bacteria, total fungi determined by microscopic count and polymerase chain reaction (PCR) assays, endotoxin, and (1→3)-β-D-glucan were determined before and after the house was tented and treated with ClO2. The laboratory study was designed to evaluate the efficiency of ClO2 treatment against known concentrations of spores of Aspergillus versicolor and Stachybotrys chartarum on filter paper (surrogate for surface treatment). These species are commonly found in damp indoor environments and were detected in the field study. Upon analysis of the environmental data from the treated house, it was found that the culturable bacteria and fungi as well as total count of fungi (as determined by microscopic count and PCR) were decreased at least 85% after the ClO2 application. However, microscopic analyses of tape samples collected from surfaces after treatment showed that the fungal structures were still present on surfaces. There was no statistically significant change in airborne endotoxin and (1→3)-β-D-glucan concentration in the field study. The laboratory study supported these results and showed a nonsignificant increase in the concentration of (1→3)-β-D-glucan after ClO2 treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Air & Waste Management Association (Air & Waste Management Association) is the property of Air & Waste Management Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlorine dioxide
KW - Chlorine compounds
KW - Microbial contamination
KW - Microbial growth
KW - Fungi
KW - Bacteria
KW - Polymerase chain reaction
N1 - Accession Number: 31859440; Clark Burton, Nancy 1; Email Address: NBurton@cdc.gov; Adhikari, Atin 2; Iossifova, Yulia 2; Grinshpun, Sergey A. 2; Reponen, Tiina 2; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, and Department of Environmental Health, University of Cincinnati, Cincinnati, OH; 2: Department of Environmental Health, University of Cincinnati, Cincinnati, OH; Issue Info: May2008, Vol. 58 Issue 5, p647; Thesaurus Term: Chlorine dioxide; Thesaurus Term: Chlorine compounds; Thesaurus Term: Microbial contamination; Thesaurus Term: Microbial growth; Thesaurus Term: Fungi; Thesaurus Term: Bacteria; Subject Term: Polymerase chain reaction; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.3155/1047-3289.58.5.647
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31859440&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105769046
T1 - Taking forward 'shaping the future of public health' in Wales.
AU - Kinghorn F
AU - Cairney S
Y1 - 2008/05//
N1 - Accession Number: 105769046. Language: English. Entry Date: 20080718. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Europe; Health Promotion/Education; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 101499616.
KW - Health Policy
KW - Health Promotion
KW - National Health Programs
KW - Interinstitutional Relations
KW - Professional Development
KW - Wales
SP - 111
EP - 112
JO - Journal of the Royal Society for the Promotion of Health
JF - Journal of the Royal Society for the Promotion of Health
JA - J R SOC PROMOT HEALTH
VL - 128
IS - 3
PB - Sage Publications, Ltd.
SN - 1466-4240
AD - South East Regional Champion for Health Promotion, National Public Health Service for Wales; Fiona.kinghorn@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Schiffman, Mark
AU - Rodríguez, Ana Cecilia
T1 - Heterogeneity in CIN3 diagnosis
JO - Lancet Oncology
JF - Lancet Oncology
Y1 - 2008/05//
VL - 9
IS - 5
M3 - Letter
SP - 404
EP - 406
SN - 14702045
N1 - Accession Number: 31924402; Schiffman, Mark 1; Email Address: schiffmm@mail.nih.gov Rodríguez, Ana Cecilia 2; Affiliation: 1: Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US Department of Health and Human Services, Washington, DC, USA 2: Proyecto Epidemiológico Guanacaste, San José, Costa Rica; Source Info: May2008, Vol. 9 Issue 5, p404; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/S1470-2045(08)70103-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31924402&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Retta, S. M.
AU - Sagripanti, J.-L.
T1 - Modeling the inactivation kinetics of bacillus spores by glutaraldehyde.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2008/05//
VL - 46
IS - 5
M3 - Article
SP - 568
EP - 574
PB - Wiley-Blackwell
SN - 02668254
AB - Aims: Our goal was to develop a mathematical kinetic model to predict the sporicidal activity of glutaraldehyde, which is an active ingredient frequently used in commercial products employed for liquid disinfection and decontamination. Methods and Results: We used our previously published data on spore inactivation by glutaraldehyde to develop a predictive model obtained by calculating multiple independent modifying functions. The model was then validated by comparing model predicted values to new experimental data. For model validation, quality-controlled spores of Bacillus athrophaeus (previously and generally known as Bacillus subtilis globigii) were exposed under conditions where several physicochemical variables were modified simultaneously, and the spore surviving fractions were measured by titration. Conclusions: The model predicted within one order of magnitude variations in sporicidal effectiveness due to changes in main parameters (glutaraldehyde concentration, temperature or time-duration of the treatment). Other parameters such pH, salinity and the effect of serum concentration were also addressed, albeit with less accuracy. Significance and Impact of the study: The model should be useful to quantitatively estimate the effectiveness of glutaraldehyde-based disinfectants, decontaminants, and germicides under the described conditions, particularly when limited data are available or when spore virulence (like that of Bacillus anthracis) precludes extensive experimentation. A similar approach could predict the effectiveness of a variety of decontaminant and disinfecting agents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Letters in Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL models
KW - COMMERCIAL products
KW - DISINFECTION & disinfectants
KW - DECONTAMINATION (From gases, chemicals, etc.)
KW - BACILLUS (Bacteria)
KW - TEMPERATURE
KW - SERUM
KW - BACTERICIDES
KW - BACILLUS anthracis
KW - Bacillus
KW - decontamination
KW - disinfection
KW - glutaraldehyde
KW - spore
N1 - Accession Number: 31641713; Retta, S. M. 1 Sagripanti, J.-L. 2; Email Address: joseluis.sagripanti@us.army.mil; Affiliation: 1: Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA 2: Edgewood Chemical Biological Center, Research Engineering and Development Command US Army, Aberdeen Proving Ground, MD, USA; Source Info: May2008, Vol. 46 Issue 5, p568; Subject Term: MATHEMATICAL models; Subject Term: COMMERCIAL products; Subject Term: DISINFECTION & disinfectants; Subject Term: DECONTAMINATION (From gases, chemicals, etc.); Subject Term: BACILLUS (Bacteria); Subject Term: TEMPERATURE; Subject Term: SERUM; Subject Term: BACTERICIDES; Subject Term: BACILLUS anthracis; Author-Supplied Keyword: Bacillus; Author-Supplied Keyword: decontamination; Author-Supplied Keyword: disinfection; Author-Supplied Keyword: glutaraldehyde; Author-Supplied Keyword: spore; NAICS/Industry Codes: 523140 Commodity Contracts Brokerage; NAICS/Industry Codes: 523130 Commodity Contracts Dealing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1472-765X.2008.02358.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31641713&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribna, M.
AU - Freeman, J. P.
AU - Paine, D.
AU - Boudreau, M. D.
T1 - Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum.
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
Y1 - 2008/05//
VL - 46
IS - 5
M3 - Article
SP - 575
EP - 580
PB - Wiley-Blackwell
SN - 02668254
AB - Aims: To investigate the effect of Aloe vera whole leaf extract on pure and mixed human gut bacterial cultures by assessing the bacterial growth and changes in the production of short chain fatty acids. Methods and Results: Bacteroides fragilis, Bifidobacterium infantis, and Eubacterium limosum were incubated with Aloe vera extracts [0%, 0·5%, 1%, 1·5% and 2%; (w/v)] for 24 and 48 h. Short chain fatty acids production was measured by gas chromatography/mass spectrometry analyses. A significant linear increase in growth response to Aloe vera supplementation was observed at 24 h for each of the bacterial cultures; however, only B. infantis and a mixed bacterial culture showed a significant positive linear dose response in growth at 48 h. In pure bacteria cultures, a significantly enhanced dose response to Aloe vera supplementation was observed in the production of acetic acid by B. infantis at 24 h and of butyric acid by E. limosum at 24 and 48 h. In the mixed bacterial culture, the production of propionic acid was reduced significantly at 24 and 48 h in a dose-dependent fashion, whereas butyric acid production showed a significant linear increase. Conclusions: The results indicated that Aloe vera possessed bacteriogenic activity in vitro and altered the production of acetic, butyric and propionic acids by micro-organisms selected for the study. Significance and Impact of the Study: The results of the study suggest that consumption of a dietary supplement, Aloe vera, may alter the production of short chain fatty acids by human intestinal microflora. [ABSTRACT FROM AUTHOR]
AB - Copyright of Letters in Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FATTY acids
KW - BACTEROIDES
KW - BIFIDOBACTERIUM
KW - MICROBIAL growth
KW - ALOE vera
KW - GAS chromatography
KW - MASS spectrometry
KW - BACTERIAL cultures
KW - ACETIC acid
KW - Aloe vera
KW - bacteria
KW - intestine
KW - short chain fatty acids
N1 - Accession Number: 31641725; Pogribna, M. 1 Freeman, J. P. 1 Paine, D. 2 Boudreau, M. D. 1; Email Address: mary.boudreau@fda.hhs.gov; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA 2: Division of Microbiology, National Center for Toxicological Research, Jefferson, AR, USA; Source Info: May2008, Vol. 46 Issue 5, p575; Subject Term: FATTY acids; Subject Term: BACTEROIDES; Subject Term: BIFIDOBACTERIUM; Subject Term: MICROBIAL growth; Subject Term: ALOE vera; Subject Term: GAS chromatography; Subject Term: MASS spectrometry; Subject Term: BACTERIAL cultures; Subject Term: ACETIC acid; Author-Supplied Keyword: Aloe vera; Author-Supplied Keyword: bacteria; Author-Supplied Keyword: intestine; Author-Supplied Keyword: short chain fatty acids; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1472-765X.2008.02346.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31641725&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Daskin, Joshua H.
AU - Calci, Kevin R.
AU - Burkhardt, William
AU - Carmichael, Ruth H.
T1 - Use of N stable isotope and microbial analyses to define wastewater influence in Mobile Bay, AL
JO - Marine Pollution Bulletin
JF - Marine Pollution Bulletin
Y1 - 2008/05//
VL - 56
IS - 5
M3 - Article
SP - 860
EP - 868
SN - 0025326X
AB - We assessed short-term ecological and potential human health effects of wastewater treatment plant (WTP) effluent by measuring δ15N‰ and microbial concentrations in oysters and suspended particulate matter (SPM). We also tested male-specific bacteriophage (MSB) as an alternative to fecal coliforms, to assess potential influence of wastewater contamination on shellfish. WTP effluent did not affect oyster growth or survival, but SPM and oysters acquired wastewater-specific δ15N‰. δ15N values were depleted near the WTP, typical of low-level processed wastewater. Fecal coliform and MSB concentrations were higher in samples taken closest to the WTP, and MSB values were significantly correlated with δ15N‰ in oyster tissues. Overall, oysters demonstrated relatively rapid integration and accumulation of wastewater-specific δ15N‰ and indicator microorganisms compared to water samples. These data suggest oysters were superior sentinels compared to water, and MSB was a more reliable indicator of wastewater influence on shellfish than fecal coliforms. [Copyright &y& Elsevier]
AB - Copyright of Marine Pollution Bulletin is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters -- Contamination
KW - Particulate matter
KW - Shellfish
KW - Industrial wastes -- Environmental aspects
KW - Coliforms
KW - Wastewater treatment
KW - Water quality management
KW - Sewage disposal plants -- Environmental aspects
KW - Sewage -- Purification
KW - Bacteria
KW - Eastern oysters
KW - Fecal coliforms
KW - Growth
KW - Male-specific bacteriophage
KW - MSB
KW - Virus
N1 - Accession Number: 32054851; Daskin, Joshua H. 1; Calci, Kevin R. 2; Burkhardt, William 2; Carmichael, Ruth H. 3,4; Email Address: rcarmichael@disl.org; Affiliations: 1: MB 0193 Brandeis University, Waltham, MA 02454, USA; 2: 1 Iberville Road, US Food and Drug Administration Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA; 3: 101 Bienville Boulevard, Dauphin Island Sea Lab, Dauphin Island, AL 36528, USA; 4: University of South Alabama, Mobile, AL, 36688, USA; Issue Info: May2008, Vol. 56 Issue 5, p860; Thesaurus Term: Oysters -- Contamination; Thesaurus Term: Particulate matter; Thesaurus Term: Shellfish; Thesaurus Term: Industrial wastes -- Environmental aspects; Thesaurus Term: Coliforms; Thesaurus Term: Wastewater treatment; Thesaurus Term: Water quality management; Subject Term: Sewage disposal plants -- Environmental aspects; Subject Term: Sewage -- Purification; Author-Supplied Keyword: Bacteria; Author-Supplied Keyword: Eastern oysters; Author-Supplied Keyword: Fecal coliforms; Author-Supplied Keyword: Growth; Author-Supplied Keyword: Male-specific bacteriophage; Author-Supplied Keyword: MSB; Author-Supplied Keyword: Virus; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 562210 Waste treatment and disposal; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 562212 Solid Waste Landfill; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.marpolbul.2008.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32054851&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Freed, Melanie
AU - Kupinski, Matthew A.
AU - Furenlid, Lars R.
AU - Wilson, Donald W.
AU - Barrett, Harrison H.
T1 - A prototype instrument for single pinhole small animal adaptive SPECT imaging.
JO - Medical Physics
JF - Medical Physics
Y1 - 2008/05//
VL - 35
IS - 5
M3 - Article
SP - 1912
EP - 1925
SN - 00942405
AB - The authors have designed and constructed a small-animal adaptive SPECT imaging system as a prototype for quantifying the potential benefit of adaptive SPECT imaging over the traditional fixed geometry approach. The optical design of the system is based on filling the detector with the region of interest for each viewing angle, maximizing the sensitivity, and optimizing the resolution in the projection images. Additional feedback rules for determining the optimal geometry of the system can be easily added to the existing control software. Preliminary data have been taken of a phantom with a small, hot, offset lesion in a flat background in both adaptive and fixed geometry modes. Comparison of the predicted system behavior with the actual system behavior is presented, along with recommendations for system improvements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGING systems in medicine
KW - MEDICAL equipment
KW - IMAGING systems
KW - BIOMEDICAL engineering
KW - MEDICAL innovations
KW - adaptive imaging
KW - instrumentation
KW - optimization
KW - small-animal SPECT
N1 - Accession Number: 31881625; Freed, Melanie 1; Email Address: melanie.freed@fda.hhs.gov Kupinski, Matthew A. 2 Furenlid, Lars R. 2 Wilson, Donald W. 2 Barrett, Harrison H. 2; Affiliation: 1: U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Room 3133, Silver Spring, Maryland 20993-0002. 2: College of Optical Sciences and Department of Radiology, University of Arizona, 1630 East University Boulevard, Tucson, Arizona 85721.; Source Info: May2008, Vol. 35 Issue 5, p1912; Subject Term: IMAGING systems in medicine; Subject Term: MEDICAL equipment; Subject Term: IMAGING systems; Subject Term: BIOMEDICAL engineering; Subject Term: MEDICAL innovations; Author-Supplied Keyword: adaptive imaging; Author-Supplied Keyword: instrumentation; Author-Supplied Keyword: optimization; Author-Supplied Keyword: small-animal SPECT; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 14p; Illustrations: 2 Color Photographs, 2 Black and White Photographs, 2 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1118/1.2896072
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prior, Richard M.
AU - Marble, William Sanders
T1 - The Overlooked Heroines: Three Silver Star Nurses of World War I.
JO - Military Medicine
JF - Military Medicine
Y1 - 2008/05//
VL - 173
IS - 5
M3 - Article
SP - 493
EP - 498
PB - AMSUS
SN - 00264075
AB - As members of forward-deployed combat hospitals, World War I Army nurses Miss Jane Rignel, Miss Linnie Leckrone, and Miss Irene Robar received the Citation Star for gallantry in attending to the wounded while under artillery fire in the month of July 1918. In 1932, they were authorized to exchange their Citation Stars for the new Silver Star Medal. Nursing in the war was difficult and required caring for patients exposed to chemical weapons and trauma while in harsh field conditions. These women were among the many Army nurses decorated for their performance in World War I. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSES
KW - ARMED Forces
KW - MEDICAL personnel
KW - ARMIES -- Medals, badges, decorations, etc.
KW - MILITARY nursing
KW - UNITED States
KW - RIGNEL, Jane
KW - LECKRONE, Linnie
KW - ROBAR, Irene
N1 - Accession Number: 32125085; Prior, Richard M. 1 Marble, William Sanders 1; Affiliation: 1: Office of Medical History, Office of The Surgeon General, U.S. Army, 5111 Leesburg Pike, Suite 401-B, Falls Church, VA 22041; Source Info: May2008, Vol. 173 Issue 5, p493; Subject Term: NURSES; Subject Term: ARMED Forces; Subject Term: MEDICAL personnel; Subject Term: ARMIES -- Medals, badges, decorations, etc.; Subject Term: MILITARY nursing; Subject Term: UNITED States; People: RIGNEL, Jane; People: LECKRONE, Linnie; People: ROBAR, Irene; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105792226
T1 - U.S. military service members' perceptions of the Anthrax Vaccine Immunization Program.
AU - Pica-Branco D
AU - Hudak RP
Y1 - 2008/05//
N1 - Accession Number: 105792226. Language: English. Entry Date: 20080815. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. NLM UID: 2984771R.
KW - Anthrax Vaccines
KW - Attitude to Health
KW - Immunization Programs -- Statistics and Numerical Data
KW - Immunization -- Psychosocial Factors
KW - Military Medicine
KW - Military Personnel -- Psychosocial Factors
KW - Patient Attitudes
KW - Perception
KW - Psychological Tests
KW - Psychometrics
KW - Surveys
KW - United States
KW - Human
SP - 429
EP - 433
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 173
IS - 5
CY - Bethesda, Maryland
PB - AMSUS
AB - This research identifies the perceptions of U.S. military service members regarding the Department of Defense Anthrax Vaccine Immunization Program (AVIP). The service members' perceptions were addressed in the dimensions of ethics, effectiveness, and safety, as well as the overall perceptions of the AVIP. The study, conducted in October 2004, randomly selected active duty service members from the uniformed services assigned to a Caribbean military base who participated in the AVIP during the period of 1998 to 2000. Their perceptions were measured with a survey instrument with 14 closed-ended, Likert-scale questions. The research demonstrated that a substantial number of service members disagreed with issues regarding the ethics, safety, and efficacy of the AVIP. We recommend enhanced training and education to increase understanding of the benefits of the AVIP.
SN - 0026-4075
AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pediatric and Maternal Health, Silver Spring, MD 20993
U2 - PMID: 18543562.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105792235
T1 - The overlooked heroines: three Silver Star nurses of World War I...Jane Rignel... Linnie Leckrone... Irene Robar
AU - Prior RM
AU - Marble WS
AU - Prior, Richard M
AU - Marble, William Sanders
Y1 - 2008/05//
N1 - Accession Number: 105792235. Language: English. Entry Date: 20080815. Revision Date: 20161119. Publication Type: journal article; biography; pictorial. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. NLM UID: 2984771R.
KW - Awards and Honors
KW - Military Nursing -- History
KW - Military Personnel -- History
KW - War
KW - Art
KW - History
KW - Rignel, Jane
KW - Leckrone, Linnie
KW - Robar, Irene
SP - 493
EP - 498
JO - Military Medicine
JF - Military Medicine
JA - MILIT MED
VL - 173
IS - 5
CY - Bethesda, Maryland
PB - AMSUS
AB - As members of forward-deployed combat hospitals, World War I Army nurses Miss Jane Rignel, Miss Linnie Leckrone, and Miss Irene Robar received the Citation Star for gallantry in attending to the wounded while under artillery fire in the month of July 1918. In 1932, they were authorized to exchange their Citation Stars for the new Silver Star Medal. Nursing in the war was difficult and required caring for patients exposed to chemical weapons and trauma while in harsh field conditions. These women were among the many Army nurses decorated for their performance in World War I.
SN - 0026-4075
AD - Office of Medical History, Office of The Surgeon General, U.S. Army, 5111 Leesburg Pike, Suite 401-B, Falls Church, VA 22041, USA
AD - Office of Medical History, Office of The Surgeon General, U.S. Army, 5111 Leesburg Pike, Suite 401-B, Falls Church, VA 22041
U2 - PMID: 18543572.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wang, Jianyong
AU - Duhart, Helen M.
AU - Xu, Zengjun
AU - Patterson, Tucker A.
AU - Newport, Glenn D.
AU - Ali, Syed F.
T1 - Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells
JO - Neurochemistry International
JF - Neurochemistry International
Y1 - 2008/05//
VL - 52
IS - 6
M3 - Article
SP - 1037
EP - 1043
SN - 01970186
AB - Abstract: Parkinson''s disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium ion) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson''s-like symptoms in humans and animals. MPTP/MPP+ produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been fully elucidated. Recently, we reported in a microarray study using a midbrain-derived dopaminergic neuronal cell line, MN9D, that MPP+ induced significant changes in a number of genes known to be associated with the dopaminergic system. In this study, we investigated the expression time courses of six genes using real-time RT-PCR, and compared them with the progressive dopaminergic depletion caused by MPP+. Our data showed that dopamine content was significantly decreased after 0.5h of MPP+ (200μM) exposure and was completely depleted after 40h. The expression of Gpr37, which is closely related to the pathogenesis of autosomal recessive juvenile Parkinsonism, was up-regulated after 0.5h, and stayed up-regulated up to 48h. Txnip, which is critical to the adjustment of cellular redox status, was down-regulated after 1h and stayed down-regulated up to 48h. Ldh1 and Cdo1, which are also involved in oxidative stress, were down-regulated after 16h and stayed down-regulated up to 48h. Two pro-apoptotic genes, Egln3 and Bnip3, were down-regulated after 2 and 4h, and stayed down-regulated up to 48h. These findings suggested that the time course of expression for multiple genes correlated with the dopaminergic depletion; and MPP+-induced neurotoxicity in MN9D cells could be used as a model to further explore the roles of these and other genes in the pathogenesis and possible treatment of PD. [Copyright &y& Elsevier]
AB - Copyright of Neurochemistry International is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARKINSON'S disease
KW - PREVENTION
KW - NEUROTOXIC agents
KW - DOPAMINERGIC neurons
KW - MEDICAL research
KW - Dopamine
KW - Gene expression
KW - MN9D cells
KW - MPP+
KW - Neurotoxicity
KW - Parkinson's disease
KW - Time course
N1 - Accession Number: 31489581; Wang, Jianyong 1; Email Address: jianyong.wang@fda.hhs.gov Duhart, Helen M. 1 Xu, Zengjun 1 Patterson, Tucker A. 1 Newport, Glenn D. 1 Ali, Syed F.; Email Address: syed.ali@fda.hhs.gov; Affiliation: 1: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: May2008, Vol. 52 Issue 6, p1037; Subject Term: PARKINSON'S disease; Subject Term: PREVENTION; Subject Term: NEUROTOXIC agents; Subject Term: DOPAMINERGIC neurons; Subject Term: MEDICAL research; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: MN9D cells; Author-Supplied Keyword: MPP+; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Parkinson's disease; Author-Supplied Keyword: Time course; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuint.2007.10.017
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Ferguson, Sherry
AU - Gopee, Neera
AU - Paule, Merle
AU - Howard, Paul
T1 - Female mini-pig performance of Temporal Response Differentiation (TRD), Incremental Repeated Acquisition (IRA), and Progressive Ratio (PR) Operant Tasks
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2008/05//
VL - 30
IS - 3
M3 - Abstract
SP - 250
EP - 250
SN - 08920362
N1 - Accession Number: 32494504; Ferguson, Sherry 1 Gopee, Neera 2 Paule, Merle 1 Howard, Paul 2; Affiliation: 1: Division of Neurotox/National Center for Toxicological Research/FDA, United States 2: Division of Biochemical Tox/National Center for Toxicological Research/FDA, United States; Source Info: May2008, Vol. 30 Issue 3, p250; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2008.03.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32494504&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Smith, Melody
AU - Gopee, Neera
AU - Howard, Paul
AU - Ferguson, Sherry
T1 - Object preferences as environmental enrichment measures in the female mini-pig
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2008/05//
VL - 30
IS - 3
M3 - Abstract
SP - 250
EP - 250
SN - 08920362
N1 - Accession Number: 32494505; Smith, Melody 1 Gopee, Neera 2 Howard, Paul 2 Ferguson, Sherry 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, United States 2: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, United States; Source Info: May2008, Vol. 30 Issue 3, p250; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2008.03.028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32494505&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Boctor, Sherin
AU - Sadovova, Natalya
AU - Wang, Cheng
AU - Ferguson, Sherry
T1 - Neonatal NMDA receptor antagonist treatment has no effects on prepulse inhibition (PPI) in postnatal day (PND) 25 Sprague–Dawley rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2008/05//
VL - 30
IS - 3
M3 - Abstract
SP - 253
EP - 253
SN - 08920362
N1 - Accession Number: 32494514; Boctor, Sherin 1,2 Sadovova, Natalya 3 Wang, Cheng 1,2 Ferguson, Sherry 1,2; Affiliation: 1: Department of Interdisciplinary Biomedical Sciences, University of Arkansas for Medical Sciences, United States 2: Division of Neurotoxicology, National Center for Toxicological Research/FDA, United States 3: Toxicologic Pathology Associates, United States; Source Info: May2008, Vol. 30 Issue 3, p253; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2008.03.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32494514&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Garey, Joan
AU - Paule, Merle
T1 - The effect of lifelong acrylamide exposure on auditory discrimination task performance in Fischer 344 rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2008/05//
VL - 30
IS - 3
M3 - Abstract
SP - 254
EP - 254
SN - 08920362
N1 - Accession Number: 32494517; Garey, Joan 1 Paule, Merle 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, United States; Source Info: May2008, Vol. 30 Issue 3, p254; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2008.03.040
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105746821
T1 - Underimmunization of american Indian and alaska native children.
AU - Groom AV
AU - Washington ML
AU - Smith PJ
AU - Bryan RT
Y1 - 2008/05//
N1 - Accession Number: 105746821. Language: English. Entry Date: 20080620. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Eskimos -- Statistics and Numerical Data
KW - Immunization -- Statistics and Numerical Data
KW - Native Americans -- Statistics and Numerical Data
KW - Alaska
KW - Child
KW - Diphtheria-Tetanus-Pertussis Vaccine -- Administration and Dosage
KW - Hepatitis B Vaccines -- Administration and Dosage
KW - HIB Vaccine -- Administration and Dosage
KW - Measles-Mumps-Rubella Vaccine -- Administration and Dosage
KW - United States
KW - Whites -- Statistics and Numerical Data
KW - Human
SP - 938
EP - 944
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 121
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE. The goal was to determine whether disparities in childhood immunization coverage exist between American Indian/Alaska Native children and non-Hispanic white children. METHODS. We compared immunization coverage with the 4 diphtheria-tetanus-pertussis, 3 poliovirus, 1 measles-mumps-rubella, 3 Haemophilus influenza type b, and 3 hepatitis B(4:3:1:3:3) series and its individual vaccine components (>/=4 doses of diphtheria, tetanus, and pertussis vaccine; >/=3 doses of oral or inactivated polio vaccine; >/=1 dose of measles, mumps, and rubella vaccine; >/=3 doses of Haemophilus influenzae type b vaccine; and >/=3 doses of hepatitis B vaccine) between American Indian/Alaska Native children and non-Hispanic white children from 2000 to 2005, using data from the National Immunization Survey. RESULTS. Although immunization coverage increased for both populations from 2001 to 2004, American Indian/Alaska Native children had significantly lower immunization coverage, compared with non-Hispanic white children, over that time period. In 2005, coverage continued to increase for American Indian/Alaska Native children but decreased for non-Hispanic white children, and no statistically significant disparity in 4:3:1:3:3 coverage was evident in that year. CONCLUSIONS. Disparities in immunization coverage for American Indian/Alaska Native children have been present, but unrecognized, since 2001. The absence of a disparity in coverage in 2005 is encouraging but is tempered by the fact that coverage for non-Hispanic white children decreased in that year.
SN - 0031-4005
AD - Indian Health Service, Division of Epidemiology and Disease Prevention, 5300 Homestead Rd NE, Albuquerque, NM 87110. amy.groom@ihs.gov.
U2 - PMID: 18450897.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105746821&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
TY - GEN
AU - Groom, AV;
AU - Washington, ML;
AU - Smith, PJ;
AU - Bryan, RT;
T1 - Underimmunization of American Indian and Alaska Native children
CT - Underimmunization of American Indian and Alaska Native children
JO - Pediatrics (USA)
JF - Pediatrics (USA)
Y1 - 2008/05/01/
VL - 121
IS - May
SP - 938
EP - 944
SN - 00314005
AD - Indian Hlth Serv, Div Epidemiol & Dis Prevent, 5300 Homestead Rd NE, Albuquerque, NM 87110, USA amy.groom@ihs.gov
N1 - Accession Number: 45-15838; Language: English; Chemical Name: Diphtheria and tetanus toxoids and pertussis vaccines--0 Polio vaccines--0 Measles, mumps and rubella vaccines--0 Influenza vaccines--0 Hepatitis B vaccines--0; Therapeutic Class: (80:12); AHFS Class: Vaccines Diphtheria and tetanus toxoids and pertussis vaccines (80:12); AHFS Class: Vaccines Polio vaccines (80:12); AHFS Class: Vaccines Measles, mumps and rubella vaccines (80:12); AHFS Class: Vaccines Influenza vaccines (80:12); AHFS Class: Vaccines Hepatitis B vaccines; References: 34; Journal Coden: PEDIAU; Human Indicator: Yes; Section Heading: Drug Evaluations
N2 - OBJECTIVE. The goal was to determine whether disparities in childhood immunization coverage exist between American Indian/ Alaska Native children and non-Hispanic white children. METHODS. We compared immunization coverage with the 4 diphtheria-tetanus-pertussis, 3 poliovirus, 1 measles-mumps-rubella, 3 Haemophilus influenza type b, and 3 hepatitis B( 4: 3: 1: 3: 3) series and its individual vaccine components (greater than or equal to4 doses of diphtheria, tetanus, and pertussis vaccine; greater than or equal to3 doses of oral or inactivated polio vaccine; greater than or equal to1 dose of measles, mumps, and rubella vaccine; greater than or equal to3 doses of Haemophilus influenzae type b vaccine; and greater than or equal to3 doses of hepatitis B vaccine) between American Indian/ Alaska Native children and non-Hispanic white children from 2000 to 2005, using data from the National Immunization Survey. RESULTS. Although immunization coverage increased for both populations from 2001 to 2004, American Indian/ Alaska Native children had significantly lower immunization coverage, compared with non-Hispanic white children, over that time period. In 2005, coverage continued to increase for American Indian/ Alaska Native children but decreased for non-Hispanic white children, and no statistically significant disparity in 4: 3: 1: 3: 3 coverage was evident in that year. CONCLUSIONS. Disparities in immunization coverage for American Indian/ Alaska Native children have been present, but unrecognized, since 2001. The absence of a disparity in coverage in 2005 is encouraging but is tempered by the fact that coverage for non-Hispanic white children decreased in that year.
KW - Diphtheria and tetanus toxoids and pertussis vaccines--pediatrics-;
KW - Polio vaccines--pediatrics-;
KW - Measles, mumps and rubella vaccines--pediatrics-;
KW - Influenza vaccines--pediatrics-;
KW - Hepatitis B vaccines--pediatrics-;
KW - Pediatrics--diphtheria and tetanus toxoids and pertussis vaccines;
KW - Diphtheria--immunization;
KW - Immunization--diphtheria;
KW - Tetanus--immunization;
KW - Immunization--tetanus;
KW - Whooping cough--immunization;
KW - Immunization--whooping cough;
KW - Vaccines--diphtheria and tetanus toxoids and pertussis;
KW - Pediatrics--polio vaccines;
KW - Poliomyelitis--immunization;
KW - Immunization--poliomyelitis;
KW - Vaccines--polio;
KW - Pediatrics--measles, mumps and rubella vaccines;
KW - Measles--immunization;
KW - Immunization--measles;
KW - Mumps--immunization;
KW - Immunization--mumps;
KW - Rubella--immunization;
KW - Immunization--rubella;
KW - Vaccines--measles, mumps and rubella;
KW - Pediatrics--influenza vaccines;
KW - Influenza--immunization;
KW - Immunization--influenza;
KW - Vaccines--influenza;
KW - Pediatrics--hepatitis B vaccines;
KW - Hepatitis B--immunization;
KW - Immunization--hepatitis B;
KW - Vaccines--hepatitis B;
KW - Interventions--immunization;
KW - Outcomes--clinical;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
ID - 105658556
T1 - Active and passive smoking and depression among Japanese workers.
AU - Nakata A
AU - Takahashi M
AU - Ikeda T
AU - Hojou M
AU - Nigam JA
AU - Swanson NG
Y1 - 2008/05//
N1 - Accession Number: 105658556. Language: English. Entry Date: 20081003. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). NLM UID: 0322116.
KW - Depression -- Epidemiology
KW - Passive Smoking -- Epidemiology
KW - Smoking -- Epidemiology
KW - Workforce -- Psychosocial Factors
KW - Adolescence
KW - Adult
KW - Center for Epidemiological Studies Depression Scale
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Japan
KW - Male
KW - Middle Age
KW - Multiple Logistic Regression
KW - Odds Ratio
KW - P-Value
KW - Psychological Tests
KW - Questionnaires
KW - Self Report
KW - Two-Tailed Test
KW - Human
SP - 451
EP - 456
JO - Preventive Medicine
JF - Preventive Medicine
JA - PREV MED
VL - 46
IS - 5
CY - Burlington, Massachusetts
PB - Academic Press Inc.
AB - OBJECTIVE: To assess the relation of passive and active smoking to depressive symptoms in 1839 men and 931 women working in a suburb of Tokyo in 2002. METHOD: Self-reported smoking history and exposure to passive smoking (no, occasional, or regular) at work and at home. Depressive symptoms according to the Center for Epidemiologic Studies Depression Scale, with a cut-off point of 16. RESULTS: Compared to never smokers unexposed to passive smoking, never smokers reporting regular and occasional exposure to passive smoking at work had increased depressive symptoms. The adjusted odds ratios (aORs) were 1.92 (95% confidence interval (CI) 1.14, 3.23) for regular exposure and 1.63 (95% CI 1.08, 2.47) for occasional exposure. Current smokers had significantly increased depressive symptoms (aOR ranging from 2.25 to 2.38) but former smokers had only marginal increases of depressive symptoms (aOR ranging from 1.43 to 1.55). Gender did not modify the effects of active/passive smoking on depressive symptoms. CONCLUSION: Passive smoking at work and current smoking appear associated with higher levels of depressive symptoms. Copyright © 2008 by Elsevier Inc.
SN - 0091-7435
AD - National Institute for Occupational Safety and Health, USA.
U2 - PMID: 18314186.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - CHILDHOOD OVERWEIGHT AND OBESITY PREVENTION.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/05//May/Jun2008
VL - 123
IS - 3
M3 - Editorial
SP - 258
EP - 259
SN - 00333549
AB - The author stresses the need to address and mitigate the epidemic of obesity among children in the U.S. According to him, childhood obesity is partly caused by poor nutrition and sedentary lifestyle including television watching and video game playing. He mentions that parents, caregivers as well as community leaders can positively affect the physical activity tendencies of children by promoting outdoor family activities and limiting the amount of time the children spend watching television or playing video games.
KW - OBESITY in children
KW - PREVENTION of obesity
KW - LIFESTYLES
KW - CHILD nutrition
KW - UNITED States
N1 - Accession Number: 31861999; Galson, Steven K. 1; Affiliation: 1: RADM, United States Surgeon General, U.S. Public Health Service; Source Info: May/Jun2008, Vol. 123 Issue 3, p258; Subject Term: OBESITY in children; Subject Term: PREVENTION of obesity; Subject Term: LIFESTYLES; Subject Term: CHILD nutrition; Subject Term: UNITED States; Number of Pages: 2p; Illustrations: 1 Black and White Photograph; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gubernot, Diane M.
AU - Boyer, Benita L.
AU - Moses, Marina S.
T1 - Animals as Early Detectors of Bioevents: Veterinary Tools and a Framework for Animal-Human Integrated Zoonotic Disease Surveillance.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/05//May/Jun2008
VL - 123
IS - 3
M3 - Article
SP - 300
EP - 315
SN - 00333549
AB - The threat of bioterrorism and emerging infectious diseases has prompted various public health agencies to recommend enhanced surveillance activities to supplement existing surveillance plans. The majority of emerging infectious diseases and bioterrorist agents are zoonotic. Animals are more sensitive to certain biological agents, and their use as clinical sentinels, as a means of early detection, is warranted. This article provides design methods for a local integrated zoonotic surveillance plan and materials developed for veterinarians to assist in the early detection of bioevents. Zoonotic surveillance in the U.S. is currently too limited and compartmentalized for broader public health objectives. To rapidly detect and respond to bioevents, collaboration and cooperation among various agencies at the federal, state, and local levels must be enhanced and maintained. Co-analysis of animal and human diseases may facilitate the response to infectious disease events and limit morbidity and mortality in both animal and human populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTERRORISM
KW - ZOONOSES
KW - COMMUNICABLE diseases
KW - PUBLIC health surveillance
KW - VETERINARIANS
N1 - Accession Number: 31862009; Gubernot, Diane M. 1; Email Address: Gubernot@alumni.gwu.edu Boyer, Benita L. 2 Moses, Marina S. 3; Affiliation: 1: The George Washington University School of Public Health and Health Services, Washington, DC, and Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD 2: Loudoun County Health Department, Virginia Department of Health, Leesburg, VA 3: The George Washington University School of Public Health and Health Services, Washington, DC; Source Info: May/Jun2008, Vol. 123 Issue 3, p300; Subject Term: BIOTERRORISM; Subject Term: ZOONOSES; Subject Term: COMMUNICABLE diseases; Subject Term: PUBLIC health surveillance; Subject Term: VETERINARIANS; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 16p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MacMahon, Kathleen L.
AU - Delaney, Lisa J.
AU - Kullman, Greg
AU - Gibbins, John D.
AU - Decker, John
AU - Kiefer, Max J.
T1 - Protecting Poultry Workers from Exposure to Avian Influenza Viruses.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/05//May/Jun2008
VL - 123
IS - 3
M3 - Article
SP - 316
EP - 322
SN - 00333549
AB - Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AGRICULTURAL laborers -- Health
KW - POULTRY
KW - AVIAN influenza
KW - ZOONOSES
KW - INFLUENZA -- Vaccination
N1 - Accession Number: 31862010; MacMahon, Kathleen L. 1; Email Address: KMacMahon@cdc.gov Delaney, Lisa J. 2 Kullman, Greg 3 Gibbins, John D. 4 Decker, John 2,5 Kiefer, Max J. 6; Affiliation: 1: Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 2: Emergency Preparedness and Response Office, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 4: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 5: Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 6: Denver Regional Office, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Denver, CO; Source Info: May/Jun2008, Vol. 123 Issue 3, p316; Subject Term: AGRICULTURAL laborers -- Health; Subject Term: POULTRY; Subject Term: AVIAN influenza; Subject Term: ZOONOSES; Subject Term: INFLUENZA -- Vaccination; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105769926
T1 - Surgeon General's perspectives.
AU - Galson SK
Y1 - 2008/05//May/Jun2008
N1 - Accession Number: 105769926. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Public Health
KW - Pediatric Obesity -- Prevention and Control
KW - Adolescence
KW - Child
KW - Life Style, Sedentary
KW - United States
SP - 258
EP - 259
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 123
IS - 3
PB - Sage Publications Inc.
SN - 0033-3549
AD - United States Surgeon General, U.S. Public Health Service
U2 - PMID: 19006963.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105769935
T1 - Protecting poultry workers from exposure to avian influenza viruses.
AU - MacMahon KL
AU - Delaney LJ
AU - Kullman G
AU - Gibbins JD
AU - Decker J
AU - Kiefer MJ
Y1 - 2008/05//May/Jun2008
N1 - Accession Number: 105769935. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Farmworkers -- Education
KW - Influenza, Avian -- Prevention and Control
KW - Occupational Exposure -- Prevention and Control
KW - Poultry
KW - Antiviral Agents -- Administration and Dosage
KW - Hygiene
KW - Influenza, Avian -- Risk Factors
KW - Protective Clothing
KW - Zoonoses
SP - 316
EP - 322
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 123
IS - 3
PB - Sage Publications Inc.
AB - Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article.
SN - 0033-3549
AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C32, 4676 Columbia Pkwy., Cincinnati, OH 45230; KMacMahon@cdc.gov
U2 - PMID: 19006973.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105769935&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - JUN ZHANG
AU - BROWN, RONALD P.
AU - SHAW, MARTIN
AU - VAIDYA, VISHAL S.
AU - ZHOU, YUZHAO
AU - ESPANDIARI, PARVANEH
AU - SADRIEH, NAKISSA
AU - STRATMEYER, MELVIN
AU - KEENAN, JOE
AU - KILTY, CORMAC G.
AU - BONVENTRE, JOSEPH V.
AU - GOERING, PETER L.
T1 - Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidney of Gentamicin-, Mercury-, or Chromium-Treated Rats: Relationship to Renal Distributions of iNOS and Nitrotyrosine.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/05//
VL - 36
IS - 3
M3 - Article
SP - 397
EP - 409
SN - 01926233
AB - Immunohistochemical studies for kidney injury molecule-1 (Kim-1), renal papillary antigen-1 (RPA-1), and renal papillary antigen-2 (RPA-2) were conducted to explore their relationship to inducible nitric oxide synthase (iNOS) and nitrotyrosine expression. Male Sprague-Dawley rats were exposed to gentamicin (100 mg/kg/day Gen, sc, for 3 days), mercury (0.25 mg Hg/kg, iv, single dose), or chromium (5 mg Cr/kg, sc, single dose) and kidney tissue was examined 24 hours or 72 hours after the last dose of the nephrotoxicant. Another group of kidneys was evaluated 24 hours after rats were administered 3 daily doses (50, 100, 150, 200, or 300 mg/kg/day) of Gen. Gen- and Cr-treated rats exhibited increased immunoreactivity of Kim-1, RPA-1, and RPA-2 largely in the S1/S2 segments and to a lesser extent in the S3 segments of the proximal tubule of the kidney, whereas Hg-treated rats showed increased immunoreactivity of Kim-1, RPA-1, and RPA-2 in the S3 segments. Up-regulation of Kim-1, RPA-1, and RPA-2 expression correlated with injured tubular epithelial cells and also correlated with immunoreactivity of iNOS and nitrotyrosine. It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antigens
KW - Nitric oxide
KW - Immunohistochemistry
KW - Rats as laboratory animals
KW - Kidneys
KW - Kidney tubules
KW - chromium
KW - gentamicin
KW - Kim-1 (kidney injury molecule-1)
KW - mercury
KW - nitrotyrosine
KW - RPA-1 (renal papillary antigen-1)
KW - RPA-2 (renal papillary antigen-2)
N1 - Accession Number: 38899301; JUN ZHANG 1; Email Address: jun.zhang@fda.hhs.gov; BROWN, RONALD P. 2; SHAW, MARTIN 3; VAIDYA, VISHAL S. 4; ZHOU, YUZHAO 2; ESPANDIARI, PARVANEH 1; SADRIEH, NAKISSA 1; STRATMEYER, MELVIN 2; KEENAN, JOE 3; KILTY, CORMAC G. 3; BONVENTRE, JOSEPH V. 4; GOERING, PETER L. 2; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 2: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA; 3: Biotrin International Ltd., Dublin, Ireland; 4: Harvard Institutes of Medicine, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Issue Info: 2008, Vol. 36 Issue 3, p397; Thesaurus Term: Antigens; Thesaurus Term: Nitric oxide; Subject Term: Immunohistochemistry; Subject Term: Rats as laboratory animals; Subject Term: Kidneys; Subject Term: Kidney tubules; Author-Supplied Keyword: chromium; Author-Supplied Keyword: gentamicin; Author-Supplied Keyword: Kim-1 (kidney injury molecule-1); Author-Supplied Keyword: mercury; Author-Supplied Keyword: nitrotyrosine; Author-Supplied Keyword: RPA-1 (renal papillary antigen-1); Author-Supplied Keyword: RPA-2 (renal papillary antigen-2); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 5 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1177/0192623308315832
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=38899301&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baylis, S. A.
AU - Heath, A. B.
AU - Chudy, M.
AU - Pisani, G.
AU - Klotz, A.
AU - Kerby, S.
AU - Gerlich, W.
T1 - An international collaborative study to establish the 2nd World Health Organization International Standard for hepatitis B virus DNA nucleic acid amplification technology-based assays.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2008/05//
VL - 94
IS - 4
M3 - Article
SP - 358
EP - 362
PB - Wiley-Blackwell
SN - 00429007
AB - Background and Objectives The aim of this study was to replace the 1st World Health Organization International Standard for hepatitis B virus DNA for nucleic acid amplification technique (NAT)-based assays (code 97/746) with a new International Standard. Two lyophilized preparations freeze dried from the same bulk were evaluated in the original collaborative study (coded 97/746 and 97/750, and termed AA and BB, respectively, in the original study). This present study re-evaluates these two preparations in terms of potency and real-time stability. Materials and Methods The 1st International Standard (97/746) and the second lyophilized preparation (97/750) were coded Samples 1 and 2, respectively, in the present study. The samples were distributed to six laboratories and assayed on four separate occasions. Accelerated thermal degradation samples of the two preparations were examined after long-term storage at 4 °C and 20 °C for more than 51 months. Results Data were returned from a total of nine different NAT-based assays, five in qualitative format and four in quantitative format. The results of this study confirm the results of the original collaborative study, with no significant differences being found in estimated international units (IU)/ml or polymerase chain reaction-detectable units/ml for the 1st International Standard (Sample 1 in this study) and the proposed replacement preparation, Sample 2 (97/750). Real-time and accelerated degradation studies indicate that both samples are very stable. Storage of both preparations at 20 °C for more than 51 months resulted in no detectable degradation. Conclusions On the basis of the data presented in this collaborative study, Sample 2 (code 97/750) was established as the 2nd International Standard for hepatitis B virus DNA for NAT-based assays with a potency of 106 IU/ml (500 000 IU/vial). [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD
KW - RESEARCH
KW - HEPATITIS B virus
KW - DNA
KW - NUCLEIC acids
KW - hepatitis B virus
KW - International Standard
KW - NAT
KW - WORLD Health Organization
N1 - Accession Number: 31625180; Baylis, S. A. 1; Email Address: baysa@pei.de Heath, A. B. 1 Chudy, M. 2 Pisani, G. 3 Klotz, A. 4 Kerby, S. 5 Gerlich, W. 6; Affiliation: 1: National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK 2: Paul Ehrlich Institute, Langen, Germany 3: Instituto Superiore di Sanità, Rome, Italy 4: Plasma Analytics, Baxter AG, Vienna, Austria 5: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 6: Institute for Medical Virology, University of Giessen, Giessen, Germany; Source Info: May2008, Vol. 94 Issue 4, p358; Subject Term: BLOOD; Subject Term: RESEARCH; Subject Term: HEPATITIS B virus; Subject Term: DNA; Subject Term: NUCLEIC acids; Author-Supplied Keyword: hepatitis B virus; Author-Supplied Keyword: International Standard; Author-Supplied Keyword: NAT; Company/Entity: WORLD Health Organization; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1423-0410.2008.01023.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31625180&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-03513-025
AN - 2008-03513-025
AU - Singh, Hari H.
AU - Rapaka, Rao S.
AU - Shurtleff, David
AU - De La Garza, Richard
T1 - NIDA drug supply & analytical services program: Providing research resources and tools to the scientific community.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2008/05//
VL - 95
IS - 1-2
SP - 182
EP - 186
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Singh, Hari H., Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-03513-025. PMID: 18484110 Partial author list: First Author & Affiliation: Singh, Hari H.; Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20080414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Dependency; Experimentation; Government Agencies; Government Programs. Classification: Substance Abuse & Addiction (3233). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: May, 2008.
AB - At the 2007 meeting of the College on Problems of Drug Dependence (CPDD), the National Institutes on Drug Abuse (NIDA) sponsored a workshop entitled, 'NIDA drug supply and analytical services program--an overview', which described the chemical supply and analytical services program and related administrative requirements for acquiring compounds and services from NIDA. The purpose of the workshop and this review is to make it widely known that NIDA provides an array of services and chemical compounds at no cost to qualified research investigators. Overall, this review will provide a detailed overview of these services, their goals, and functions. In addition, the drug enforcement administration (DEA) requirements for obtaining controlled substances for research are described so that investigators can take full advantage of the NIDA drug supply program. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug supply & analytical services program
KW - controlled substances
KW - drug dependence
KW - drug abuse
KW - research
KW - National Institutes on Drug Abuse
KW - 2008
KW - Drug Abuse
KW - Drug Dependency
KW - Experimentation
KW - Government Agencies
KW - Government Programs
KW - 2008
DO - 10.1016/j.drugalcdep.2008.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03513-025&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1943-4469
UR -
UR - hsingh1@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06221-006
AN - 2008-06221-006
AU - McMillen, J. Curtis
AU - Lee, Bethany R.
AU - Jonson-Reid, Melissa
T1 - Outcomes for youth residential treatment programs using administrative data from the child welfare system: A risk-adjustment application.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2008/05//
VL - 35
IS - 3
SP - 189
EP - 197
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - McMillen, J. Curtis, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1196, St. Louis, MO, US, 63130
N1 - Accession Number: 2008-06221-006. PMID: 18176838 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: McMillen, J. Curtis; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20081020. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychiatry; Child Welfare; Mental Health Programs; Residential Care Institutions; Risk Assessment. Classification: Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2008.
AB - This study assessed whether administrative data from the public child welfare system could be used to develop risk-adjusted performance reports for residential mental health programs for adolescents. Regression methods were used with 3,759 residential treatment spells for 2,784 children and youth to determine which outcomes could be adequately risk adjusted for case mix. Expected outcomes were created for each residential program given its case mix; then, expected and achieved outcomes were compared. For most programs, achieved results did not differ significantly from expected results for individual outcomes. Overall, outcomes achieved were not impressive. Only one quarter of spells resulted in a youth being maintained in a single less restrictive setting in the year following discharge. Methodological implications of this study suggest further refinements are needed for child welfare administrative data in order to develop risk-adjusted report cards of program performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - residential treatment programs
KW - administrative data
KW - child welfare
KW - risk adjustment
KW - residential mental health programs
KW - adolescents
KW - 2008
KW - Adolescent Psychiatry
KW - Child Welfare
KW - Mental Health Programs
KW - Residential Care Institutions
KW - Risk Assessment
KW - 2008
U1 - Sponsor: National Institute of Mental Health. Grant: R245 50857; P30 MH068579. Recipients: No recipient indicated
DO - 10.1007/s10488-007-0155-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06221-006&site=ehost-live&scope=site
UR - cmcmille@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05136-022
AN - 2008-05136-022
AU - Xiang, Lianbin
AU - Szebeni, Katalin
AU - Szebeni, Attila
AU - Klimek, Violetta
AU - Stockmeier, Craig A.
AU - Karolewicz, Beata
AU - Kalbfleisch, John
AU - Ordway, Gregory A.
T1 - Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2008/05//
VL - 1207
SP - 214
EP - 224
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Ordway, Gregory A., Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, P.O. Box 70577, Johnson City, TN, US, 37614
N1 - Accession Number: 2008-05136-022. PMID: 18371940 Partial author list: First Author & Affiliation: Xiang, Lianbin; Department of Pharmacology, East Tennessee State University, Johnson City, TN, US. Release Date: 20080825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Amygdala; Dopamine; Gene Expression; Major Depression; Ribonucleic Acid. Minor Descriptor: Neurotransmission; mRNA. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: May, 2008.
AB - Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative real-time RT-PCR was used to investigate the regional distribution of gene expression of DA receptors in the human amygdala. In addition, relative levels of mRNA of DA receptors in the basal amygdaloid nucleus were measured postmortem in subjects with major depression and normal control subjects. All five subtypes of DA receptor mRNA were detected in all amygdaloid subnuclei, although D1, D2, and D4 receptor mRNAs were more abundant than D3 and D5 mRNAs by an order of magnitude. The highest level of D1 mRNA was found in the central nucleus, whereas D2 mRNA was the most abundant in the basal nucleus. Levels of D4 mRNA were highest in the basal and central nuclei. In the basal nucleus, amounts of D4, but not D1 or D2, mRNAs were significantly higher in subjects with major depression as compared to control subjects. These findings demonstrate that the D1, D2 and D4 receptors are the major subtypes of DA receptors in the human amygdala. Elevated DA receptor gene expression in depressive subjects further implicates altered dopaminergic transmission in the amygdala in depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dopamine receptors
KW - gene expression
KW - human amygdaloid nuclei
KW - D4 receptor
KW - mRNA
KW - major depression
KW - 2008
KW - Amygdala
KW - Dopamine
KW - Gene Expression
KW - Major Depression
KW - Ribonucleic Acid
KW - Neurotransmission
KW - mRNA
KW - 2008
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH63187; MH46692; MH02031; MH67996. Recipients: No recipient indicated
U1 - Sponsor: National Center for Research Resources, US. Grant: RR17701. Recipients: No recipient indicated
DO - 10.1016/j.brainres.2008.02.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05136-022&site=ehost-live&scope=site
UR - ordway@etsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06221-010
AN - 2008-06221-010
AU - Howell, Embry M.
AU - Teich, Judith
T1 - Variations in Medicaid mental health service use and cost for children.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2008/05//
VL - 35
IS - 3
SP - 220
EP - 228
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Teich, Judith, Substance Abuse and Mental Health Services Administration, One Choke Cherry Rd., Room 6-1065, Rockville, MD, US, 20857
N1 - Accession Number: 2008-06221-010. PMID: 18259853 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Howell, Embry M.; Urban Institute, Washington, DC, US. Release Date: 20081020. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Utilization; Medicaid; Mental Health Services; Pediatrics. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2008.
AB - Mental health care is a critical component of Medicaid for children. This study used summary tables drawn from the 1999 Medicaid Analytic Extract (MAX) files, the first available Medicaid data for the entire US, to examine fee-for-service Medicaid in 23 selected states. Data show that 9% of children and youth (ages 0-21) had a mental health-related diagnosis on a claim, varying from 5% to 17% across the states. The proportion increased with age, and was higher for boys. Over half of those diagnosed received psychotropic medication, and approximately 7% had an inpatient psychiatric admission during the year. Mental health costs accounted for 26.5% of total fee-for-service Medicaid expenditures, varying from 14% to 61% depending on the state. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Medicaid
KW - mental health service use
KW - mental health service costs
KW - children
KW - 2008
KW - Health Care Costs
KW - Health Care Utilization
KW - Medicaid
KW - Mental Health Services
KW - Pediatrics
KW - 2008
DO - 10.1007/s10488-008-0163-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06221-010&site=ehost-live&scope=site
UR - jteich@samhsa.hhs.gov
UR - ehowell@ui.urban.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05183-006
AN - 2008-05183-006
AU - Salem, Sam
AU - Genaidy, Ash
AU - Albers, James
AU - Shell, Richard
AU - Sobeih, Tarek
AU - Rinder, Maria M.
T1 - Use and acceptability of reduced-weight Portland cement bags in masonry construction: An observational pilot study.
T3 - Part II or II: Evidence-based safety and health engineering
JF - Human Factors and Ergonomics in Manufacturing
JO - Human Factors and Ergonomics in Manufacturing
JA - Hum Factors Ergon Manuf
Y1 - 2008/05//May-Jun, 2008
VL - 18
IS - 3
SP - 253
EP - 269
CY - US
PB - John Wiley & Sons
SN - 1090-8471
SN - 1520-6564
AD - Salem, Sam, Civil and Environmental Engineering Department, University of Cincinnati, Cincinnati, OH, US, 45221
N1 - Accession Number: 2008-05183-006. Other Journal Title: Human Factors and Ergonomics in Manufacturing & Service Industries. Partial author list: First Author & Affiliation: Salem, Sam; Civil and Environmental Engineering Department, University of Cincinnati, Cincinnati, OH, US. Release Date: 20090504. Correction Date: 20100118. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Musculoskeletal Disorders; Occupational Safety; Risk Factors. Minor Descriptor: Health. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: May-Jun, 2008.
AB - Background: Mason tenders are involved in semi- and unskilled work in support of bricklayers and block layers. Their work consists of manually transporting building materials and equipment, supplying individual brick/block layers with materials, and mixing and stocking mortar. Objective: The purpose of this pilot study is to determine the current availability and acceptability of reduced-weight Portland cement bags among mason contractors, cement suppliers, and manufacturers as a vehicle to decrease the exposure of mason tenders to physical risk factors for musculoskeletal disorders (MSD). Methods: Forty-six producers, suppliers, and contractors that use Portland cement bags were used in this observational exploratory study. A questionnaire was administrated over the phone and data were collected regarding availability, practice of use, and preferences between full- and reduced-weight Portland cement bags. Results: Only 17% of the companies produce/supply/use the reduced-weight cement bags. The main factors mentioned by the companies that influence the nonuse of small bags are reduced demand; increased cost; storage, shipping, and handling difficulty; special equipment requirements; and special packaging. Only 11% of companies interviewed are aware of the National Institute for Occupational Safety and Health (NIOSH) lifting recommendations that the maximum lifted weight should be 51 Ib. Conclusions: This exploratory study suggests that reduced cement bags may not be in wide use by producers/suppliers/users of Portland cement. A full-scale study is recommended to confirm these practices and find ways to significantly reduce the risk to which masonry workers are exposed. Application: The potential application of this study can be the development of new guidelines regarding the production/supplying/usage of 47 Ib cement bags. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Portland cement bags
KW - masonry construction
KW - risk factors
KW - musculoskeletal disorders
KW - 2008
KW - Musculoskeletal Disorders
KW - Occupational Safety
KW - Risk Factors
KW - Health
KW - 2008
DO - 10.1002/hfm.20111
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05183-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08743-005
AN - 2008-08743-005
AU - Sale, Elizabeth
AU - Bellamy, Nikki
AU - Springer, J. Fred
AU - Wang, Min Qi
T1 - Quality of provider-participant relationships and enhancement of adolescent social skills.
JF - The Journal of Primary Prevention
JO - The Journal of Primary Prevention
JA - J Prim Prev
Y1 - 2008/05//
VL - 29
IS - 3
SP - 263
EP - 278
CY - Germany
PB - Springer
SN - 0278-095X
SN - 1573-6547
AD - Sale, Elizabeth, Missouri Institute of Mental Health, 3400 Arsenal Street, St. Louis, MO, US, 63139
N1 - Accession Number: 2008-08743-005. PMID: 18446439 Partial author list: First Author & Affiliation: Sale, Elizabeth; EMT Associates, Inc., Sacramento, CA, US. Release Date: 20080707. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Sale, Elizabeth. Major Descriptor: Adolescent Development; Mental Health Services; Prevention; Relationship Quality; Social Skills Training. Minor Descriptor: Treatment Outcomes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Youth Outcome Instrument. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: May, 2008.
AB - This study adds to the limited research on the potential importance of the quality of the relationship between adult prevention service providers and youth participants in enhancing social skills and strengthening prevention outcomes. Study subjects were drawn from seven prevention programs funded under a Youth Mentoring Initiative by the Center for Substance Abuse Prevention in the Substance Abuse and Mental Health Services Administration. These programs maintain a relationship-based service focus but use a variety of one-on-one, group, volunteer, and paid staff service formats. Study results showed that youth who perceived a higher level of trust, mutuality and empathy in their relationship with providers experienced significantly greater improvements in social skills (i.e., cooperation, self-control, assertiveness, and empathy) than program participants who perceived a lower quality relationship with adult providers. These findings underscore the importance of recruitment, training and supervisory practices that promote staff and volunteer skills in achieving high quality relationships with youth participants regardless of the specific intervention strategy. Editors' Strategic Implications: Practitioners and policymakers should review the authors' findings about the importance of individual adult skills in building protective mentoring relationships. The impact of relationship quality, rather than setting, suggests that the scope of effective prevention practice can be broadened beyond the confines of formal prevention programming to any place in which caring and skilled adults interact with youth. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - provider-participant relationship quality
KW - adolescent social skills
KW - adult prevention service providers
KW - prevention outcomes
KW - 2008
KW - Adolescent Development
KW - Mental Health Services
KW - Prevention
KW - Relationship Quality
KW - Social Skills Training
KW - Treatment Outcomes
KW - 2008
U1 - Sponsor: Sponsor name not included. Grant: Cooperative agreement 1UDI SP09563. Recipients: Sale, Elizabeth; Springer, J. Fred; Wang, Min Qi
DO - 10.1007/s10935-008-0138-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08743-005&site=ehost-live&scope=site
UR - liz.sale@mimh.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12242-007
AN - 2008-12242-007
AU - Hong, Song-Iee
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
AU - Wentz, Joan D.
AU - Rubin, Eugene
T1 - The quality of medical care for comorbid conditions of depressed elders.
JF - Aging & Mental Health
JO - Aging & Mental Health
JA - Aging Ment Health
Y1 - 2008/05//
VL - 12
IS - 3
SP - 323
EP - 332
CY - United Kingdom
PB - Taylor & Francis
SN - 1360-7863
SN - 1364-6915
AD - Hong, Song-Iee
N1 - Accession Number: 2008-12242-007. PMID: 18728945 Partial author list: First Author & Affiliation: Hong, Song-Iee; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Health Care Services; Health Insurance; Major Depression; Quality of Care. Minor Descriptor: Geriatrics. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Cumulative Illness Rating Scale for Geriatrics; Medicare Current Beneficiary Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: May, 2008.
AB - Objectives: In light of large variation in the quality of medical care, this study assesses the extent to which medical care for depressed elders is consistent with systematic quality standards. Method: Using the Donabedian model, we assess factors related to two quality measures: medical service fit and medical provider contact. We assessed 110 depressed older adults with comorbid conditions through practical guidelines of medical services. Results: We found large variation in the quality of medical care and differences between two quality measures. Structure (Medigap insurance and clinical factors) and process factors (medical professional visits, ER visits, and adequacy of informal care) influenced the quality of medical care. Conclusion: Emphasizing accuracy in quality measures, quality disparities by medical conditions call attention to the risky population with certain conditions targeted for closer follow-up. Appropriate medical care processes can enhance the quality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality of medical care
KW - comorbid conditions
KW - depressed elders
KW - medical insurance
KW - health care services
KW - 2008
KW - Comorbidity
KW - Health Care Services
KW - Health Insurance
KW - Major Depression
KW - Quality of Care
KW - Geriatrics
KW - 2008
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH56208. Recipients: No recipient indicated
DO - 10.1080/13607860802121118
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12242-007&site=ehost-live&scope=site
UR - shong@gwbmail.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06701-010
AN - 2008-06701-010
AU - Drukker, Marjan
AU - van Dillen, Kim
AU - Bak, Maarten
AU - Mengelers, Ron
AU - van Os, Jim
AU - Delespaul, Philippe
T1 - The use of the Camberwell Assessment of Need in treatment: What unmet needs can be met?
JF - Social Psychiatry and Psychiatric Epidemiology
JO - Social Psychiatry and Psychiatric Epidemiology
JA - Soc Psychiatry Psychiatr Epidemiol
Y1 - 2008/05//
VL - 43
IS - 5
SP - 410
EP - 417
CY - Germany
PB - Springer
SN - 0933-7954
SN - 1433-9285
AD - Drukker, Marjan, Dept. of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, P.O.Box 616, Location Vijverdal, 6200 MD, Maastricht, Netherlands
N1 - Accession Number: 2008-06701-010. PMID: 18163188 Other Journal Title: Social Psychiatry. Partial author list: First Author & Affiliation: Drukker, Marjan; Youth Health Care Division, Public Health Service South Limburg, Maastricht, Netherlands. Release Date: 20080602. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Service Needs; Needs Assessment; Psychopathology; Treatment Outcomes. Minor Descriptor: Hospitals; Psychiatric Patients. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Camberwell Assessment of Need; Brief Psychiatric Rating Scale DOI: 10.1037/t01554-000; Global Assessment of Functioning Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 2008.
AB - Background: A useful way of operationalising treatment effects in routine outcome assessment data may be to assess the rate at which unmet needs at time point t change to met needs at time point t + 1. Methods: Data were obtained from the local Cumulative Needs for Care Register (CNCR), a cumulative data set of needs (Camberwell Assessment of Need), psychopathology, well being and functioning of psychiatric patients living both inside and outside the hospital, in a circumscribed geographical area. Results: In the group of relatively new patients, the number of met needs (sum score) increased over time. Higher unmet needs sum score predicted higher met needs at time point t + 1. Unmet needs in the areas of accommodation, household skills, self-care, safety to others (in new patients only), alcohol, drugs, money and benefits were associated with met needs on these items at time point t + 1, but there was no such association for occupation/daytime activities, psychotic symptoms, psychological distress and self-harm. Conclusion: Treatment outcomes in psychiatric practice can be usefully tracked and quantified using the rate of change from unmet to met needs. Needs in the area of the ability to live independently may represent outcomes that are more sensitive to treatment effects than needs in the realm of psychopathology and daytime activities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Camberwell Assessment of Need
KW - treatment needs
KW - unmet needs
KW - routine outcome assessment
KW - psychopathology
KW - psychiatric patients
KW - 2008
KW - Health Care Services
KW - Health Service Needs
KW - Needs Assessment
KW - Psychopathology
KW - Treatment Outcomes
KW - Hospitals
KW - Psychiatric Patients
KW - 2008
U1 - Sponsor: Netherlands Organisation for Health Research and Development, Netherlands. Recipients: No recipient indicated
DO - 10.1007/s00127-007-0301-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06701-010&site=ehost-live&scope=site
UR - marjan.drukker@sp.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06308-004
AN - 2008-06308-004
AU - Pica-Branco, Denise
AU - Hudak, Ronald P.
T1 - U.S. military service members' perceptions of the anthrax vaccine immunization program.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2008/05//
VL - 173
IS - 5
SP - 429
EP - 439
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Pica-Branco, Denise, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pediatric and Maternal Health, Silver Spring, MD, US, 20993
N1 - Accession Number: 2008-06308-004. Partial author list: First Author & Affiliation: Pica-Branco, Denise; Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pediatric and Maternal Health, Silver Spring, MD, US. Release Date: 20090427. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Ethics; Immunization; Military Personnel; Safety. Classification: Promotion & Maintenance of Health & Wellness (3365); Military Psychology (3800). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: May, 2008.
AB - This research identifies the perceptions of U.S. military service members regarding the Department of Defense Anthrax Vaccine Immunization Program (AVIP). The service members' perceptions were addressed in the dimensions of ethics, effectiveness, and safety, as well as the overall perceptions of the AVIP. The study, conducted in October 2004, randomly selected active duty service members from the uniformed services assigned to a Caribbean military base who participated in the AVIP during the period of 1998 to 2000. Their perceptions were measured with a survey instrument with 14 closed-ended, Likert-scale questions. The research demonstrated that a substantial number of service members disagreed with issues regarding the ethics, safety, and efficacy of the AVIP. We recommend enhanced training and education to increase understanding of the benefits of the AVIP. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - U.S. military service members perceptions
KW - anthrax vaccine immunization program
KW - ethics
KW - safety
KW - 2008
KW - Ethics
KW - Immunization
KW - Military Personnel
KW - Safety
KW - 2008
DO - 10.7205/MILMED.173.5.429
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06308-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05787-006
AN - 2008-05787-006
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Ikeda, Tomoko
AU - Hojou, Minoru
AU - Nigam, Jeannie A.
AU - Swanson, Naomi G.
T1 - Active and passive smoking and depression among Japanese workers.
JF - Preventive Medicine: An International Journal Devoted to Practice and Theory
JO - Preventive Medicine: An International Journal Devoted to Practice and Theory
JA - Prev Med
Y1 - 2008/05//
VL - 46
IS - 5
SP - 451
EP - 456
CY - Netherlands
PB - Elsevier Science
SN - 0091-7435
AD - Nakata, Akinori, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, MSC2, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-05787-006. PMID: 18314186 Other Journal Title: Preventative Medicine: An International Journal Devoted to Practice & Theory. Partial author list: First Author & Affiliation: Nakata, Akinori; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Major Depression; Passive Smoking; Personnel; Symptoms; Tobacco Smoking. Classification: Affective Disorders (3211); Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: May, 2008.
AB - Objective: To assess the relation of passive and active smoking to depressive symptoms in 1839 men and 931 women working in a suburb of Tokyo in 2002. Method: Self-reported smoking history and exposure to passive smoking (no, occasional, or regular) at work and at home. Depressive symptoms according to the Center for Epidemiologic Studies Depression Scale, with a cut-off point of 16. Results: Compared to never smokers unexposed to passive smoking, never smokers reporting regular and occasional exposure to passive smoking at work had increased depressive symptoms. The adjusted odds ratios (aORs) were 1.92 (95% confidence interval (CI) 1.14, 3.23) for regular exposure and 1.63 (95% CI 1.08, 2.47) for occasional exposure. Current smokers had significantly increased depressive symptoms (aOR ranging from 2.25 to 2.38) but former smokers had only marginal increases of depressive symptoms (aOR ranging from 1.43 to 1.55). Gender did not modify the effects of active/passive smoking on depressive symptoms. Conclusion: Passive smoking at work and current smoking appear associated with higher levels of depressive symptoms. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - active smoking
KW - passive smoking
KW - depressive symptoms
KW - Japanese workers
KW - 2008
KW - Major Depression
KW - Passive Smoking
KW - Personnel
KW - Symptoms
KW - Tobacco Smoking
KW - 2008
DO - 10.1016/j.ypmed.2008.01.024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05787-006&site=ehost-live&scope=site
UR - cji5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06171-001
AN - 2008-06171-001
AU - Chen, Feinian
AU - Curran, Patrick J.
AU - Bollen, Kenneth A.
AU - Kirby, James
AU - Paxton, Pamela
T1 - An empirical evaluation of the use of fixed cutoff points in RMSEA test statistic in structural equation models.
JF - Sociological Methods & Research
JO - Sociological Methods & Research
JA - Sociol Methods Res
Y1 - 2008/05//
VL - 36
IS - 4
SP - 462
EP - 494
CY - US
PB - Sage Publications
SN - 0049-1241
SN - 1552-8294
N1 - Accession Number: 2008-06171-001. Partial author list: First Author & Affiliation: Chen, Feinian; North Carolina State University, Raleigh, NC, US. Release Date: 20090504. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Evaluation; Simulation; Statistics; Structural Equation Modeling. Minor Descriptor: Goodness of Fit; Sample Size. Classification: Statistics & Mathematics (2240). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 33. Issue Publication Date: May, 2008.
AB - This article is an empirical evaluation of the choice of fixed cutoff points in assessing the root mean square error of approximation (RMSEA) test statistic as a measure of goodness-of-fit in Structural Equation Models. Using simulation data, the authors first examine whether there is any empirical evidence for the use of a universal cutoff, and then compare the practice of using the point estimate of the RMSEA alone versus that of using it jointly with its related confidence interval. The results of the study demonstrate that there is little empirical support for the use of .05 or any other value as universal cutoff values to determine adequate model fit, regardless of whether the point estimate is used alone or jointly with the confidence interval. The authors' analyses suggest that to achieve a certain level of power or Type I error rate, the choice of cutoff values depends on model specifications, degrees of freedom, and sample size. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - empirical evaluation
KW - fixed cutoff points
KW - root mean square error of approximation test statistic
KW - structural equation models
KW - goodness of fit
KW - 2008
KW - Evaluation
KW - Simulation
KW - Statistics
KW - Structural Equation Modeling
KW - Goodness of Fit
KW - Sample Size
KW - 2008
DO - 10.1177/0049124108314720
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06171-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06004-002
AN - 2008-06004-002
AU - Baum, A. E.
AU - Hamshere, M.
AU - Green, E.
AU - Cichon, S.
AU - Rietschel, M.
AU - Noethen, M. M.
AU - Craddock, N.
AU - McMahon, F. J.
T1 - Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2008/05//
VL - 13
IS - 5
SP - 466
EP - 469
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Baum, A. E.
N1 - Accession Number: 2008-06004-002. Partial author list: First Author & Affiliation: Baum, A. E.; Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20081020. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Letter. Language: English. Grant Information: Baum, A. E. Major Descriptor: Bipolar Disorder; Genes; Genetics; Nucleotides; Polymorphism. Minor Descriptor: Genome. Classification: Affective Disorders (3211). Population: Human (10). Methodology: Meta Analysis. References Available: Y. Page Count: 4. Issue Publication Date: May, 2008.
AB - This early meta-analysis reveals several points of agreement between the two genome-wide association studies (GWAS) of bipolar disorder published to date. There is significant overlap in association signals, and consistent but modest evidence of association across both studies for at least two single-nucleotide polymorphisms (SNPs) near two distinct genes. Detailed consideration of the wider distribution of association signals across studies, rather than an unjustified focus on 'top hits', may prove to be a valuable strategy in complex genetics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genome-wide association studies
KW - single-nucleotide polymorphisms
KW - complex genetics
KW - bipolar disorder
KW - 2008
KW - Bipolar Disorder
KW - Genes
KW - Genetics
KW - Nucleotides
KW - Polymorphism
KW - Genome
KW - 2008
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program. Recipients: Baum, A. E.; McMahon, F. J.
U1 - Sponsor: Wellcome Trust. Recipients: Hamshere, M.; Green, E.; Craddock, N.
U1 - Sponsor: Medical Research Council, United Kingdom. Recipients: Hamshere, M.; Green, E.; Craddock, N.
U1 - Sponsor: Bundesministerium für Bildung und Forschung, National Genomic Network. Recipients: Cichon, S.; Rietschel, M.; Noethen, M. M.
U1 - Sponsor: Alfried Krupp von Bohlen und Halbach-Stiftung. Recipients: Noethen, M. M.
DO - 10.1038/mp.2008.16
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06004-002&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR - ORCID: 0000-0002-9475-086X
UR -
UR - bauma@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-05652-004
AN - 2008-05652-004
AU - Mukamel, Dana B.
AU - Glance, Laurent G.
AU - Li, Yue
AU - Weimer, David L.
AU - Spector, William D.
AU - Zinn, Jacqueline S.
AU - Mosqueda, Laura
T1 - Does risk adjustment of the CMS quality measures for nursing homes matter?
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2008/05//
VL - 46
IS - 5
SP - 532
EP - 541
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Mukamel, Dana B., University of California, Irvine, Center for Health Policy Research, 111 Academy, Suite 220, Irvine, CA, US, 92697-5800
N1 - Accession Number: 2008-05652-004. PMID: 18438202 Partial author list: First Author & Affiliation: Mukamel, Dana B.; University of California, Irvine, Center for Health Policy Research, Irvine, CA, US. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Insurance; Medicaid; Medicare; Nursing Homes; Quality of Services. Minor Descriptor: Risk Factors. Classification: Nursing Homes & Residential Care (3377). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: May, 2008.
AB - Background: The Centers for Medicare and Medicaid Services (CMS) publish a report card for nursing homes with 19 clinical quality measures (QMs). These measures include minimal risk adjustment. Objectives: To develop QMs with more extensive risk adjustment and to investigate the impact on quality rankings. Research Design: Retrospective analysis of individual level data reported in the Minimum Data Set (MDS). Random effect logistic models were used to estimate risk adjustment models for 5 outcomes: pressure ulcers for high and low risk patients, physical restraints, and pain for long- and short-stay patients. These models were used to create 5 QMs with extended risk adjustment, enhanced QMs (EQMs). The EQMs were compared with the corresponding QMs. Subjects: All (17,469) nursing homes that reported MDS data in the period 2001-2005, and their 9.6 million residents. Measures: QMs were compared with EQMs for all nursing homes in terms of agreement on outlier identification: Kappa, false positive and false negative error rates. Results: Kappa values ranged from 0.63 to 0.90. False positive and negative error rates ranged from 8% to 37%. Agreement between QMs and EQMs was better on high quality rather than on low quality. Conclusions: More extensive risk adjustment changes quality ranking of nursing homes and should be considered as potential improvement to the current QMs. Other methodological issues related to construction of the QMs should also be investigated to determine if they are important in the context of nursing home care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical quality measures
KW - nursing homes
KW - medicare services
KW - medicaid services
KW - risk adjustment
KW - health insurance
KW - 2008
KW - Health Insurance
KW - Medicaid
KW - Medicare
KW - Nursing Homes
KW - Quality of Services
KW - Risk Factors
KW - 2008
U1 - Sponsor: National Institute on Aging. Grant: AG023177; AG029608. Recipients: No recipient indicated
DO - 10.1097/MLR.0b013e31816099c5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-05652-004&site=ehost-live&scope=site
UR - dmukamel@uci.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-03637-006
AN - 2008-03637-006
AU - French, Jacqueline A.
AU - Meador, Kimford
AU - Cnaan, Avital
AU - Gilliam, Frank
AU - Conway, Jill
AU - Araojo, Richardae
AU - Feibus, Karen
T1 - Ethical and regulatory issues related to pregnancy registries and their outcomes.
JF - Epilepsy & Behavior
JO - Epilepsy & Behavior
JA - Epilepsy Behav
Y1 - 2008/05//
VL - 12
IS - 4
SP - 587
EP - 591
CY - Netherlands
PB - Elsevier Science
SN - 1525-5050
AD - French, Jacqueline A., NYU Comprehensive Epilepsy Center, 403 East 34th Street, 4th floor, New York, NY, US, 10016
N1 - Accession Number: 2008-03637-006. PMID: 18158272 Partial author list: First Author & Affiliation: French, Jacqueline A.; New York University, New York, NY, US. Release Date: 20080414. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epilepsy; Pregnancy; Professional Ethics; Professional Standards. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10); Female (40). References Available: Y. Page Count: 5. Issue Publication Date: May, 2008.
AB - This article addresses important ethical principles surrounding the development of pregnancy registries, as well as those related to reporting of outcomes, by both investigators and regulators. These issues are of concern to women with epilepsy, health care providers, researchers, regulators who must assess and communicate risk, and companies that provide treatments that may impact on pregnancy. Pregnancy registries should be devised so that the interests of science, society, and the individual are all considered. For example, there may be ethical issues that relate to how women are chosen to participate in the registry and how informed consent is obtained. In most cases, consent is required for both the mother and the infant. Some institutional review boards will require that consent be obtained by someone other than the woman's physician. Once data are obtained, there may be an issue as to when results should be released. Options are to release data when there is the first indication of a concerning finding, thereby potentially preventing exposure in the largest number of women, versus waiting until the finding is absolutely confirmed. In a related issue, there are questions of when and how regulatory agencies should change labeling based on findings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pregnancy registries
KW - epilepsy
KW - ethical principles
KW - regulatory issues
KW - outcomes
KW - 2008
KW - Epilepsy
KW - Pregnancy
KW - Professional Ethics
KW - Professional Standards
KW - 2008
DO - 10.1016/j.yebeh.2007.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-03637-006&site=ehost-live&scope=site
UR - Jacqueline.French@comcast.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-04420-008
AN - 2008-04420-008
AU - Valentine, Nicole
AU - Darby, Charles
AU - Bonsel, Gouke J.
T1 - Which aspects of non-clinical quality of care are most important? Results from WHO's general population surveys of 'health systems responsiveness' in 41 countries.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2008/05//
VL - 66
IS - 9
SP - 1939
EP - 1950
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Valentine, Nicole, Information, Evidence and Research Cluster, World Health Organization, Ave Appia 20, Geneva, Switzerland
N1 - Accession Number: 2008-04420-008. PMID: 18313822 Partial author list: First Author & Affiliation: Valentine, Nicole; Information, Evidence and Research Cluster, World Health Organization, Geneva, Switzerland. Release Date: 20080505. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Quality of Care. Minor Descriptor: Health; Organizations. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Argentina; Belgium; Bahrain; Bulgaria; China; Colombia; Canada; Costa Rica; Croatia; Czech Republic; Estonia; Egypt; Finland; France; Georgia; Germany; Iceland; Ireland; India; Indonesia; Iran; Italy; Jordan; Latvia; Luxembourg; Malta; Morocco; Mexico; Netherlands; Nigeria; Oman; Portugal; Romania; Russia; Spain; Sweden; Syria; Turkey; United Arab Emirates; Venezuela; Slovakia. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 12. Issue Publication Date: May, 2008.
AB - Quality of care research has reached some agreement on concepts like structure, process and outcome, and non-clinical versus clinical processes of care. These concepts are commonly explored through surveys measuring patient experiences, yet few surveys have focused on patient, or 'user', priorities across different quality dimensions. Population surveys on priorities can contribute to, although not replace participation in, policy decision making. Using 105,806 survey interview records from the World Health Organization's (WHO's) general population surveys in 41 countries, this paper describes the relative importance of eight domains in the non-clinical quality of care concept WHO calls 'health systems responsiveness'. Responsiveness domains are divided into interpersonal domains (dignity, autonomy, communication and confidentiality) and structural domains (quality of basic amenities, choice, access to social support networks and prompt attention). This paper explores variations in domain importance by country-level variables (country of residence, human development, health system expenditure, and 'geographic zones') and by subpopulations defined by sex, age, education, health status, and utilization. Most respondents selected prompt attention as the most important domain. Dignity was selected second, followed by communication. Access to social support networks was identified as the least important domain. In general, convergence in rankings was stronger across subpopulations within countries than across countries. Yet even across diverse countries, there was more convergence than divergence in views. These results provide a ranking of quality of care criteria for consideration during health reform processes further to the usual emphasis on clinical quality and supply-side efficiency. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - non-clinical quality of care
KW - health systems responsiveness
KW - World Health Organization
KW - clinical processes
KW - 2008
KW - Health Care Services
KW - Quality of Care
KW - Health
KW - Organizations
KW - 2008
DO - 10.1016/j.socscimed.2007.12.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-04420-008&site=ehost-live&scope=site
UR - g.j.bonsel@amc.uva.nl
UR - charles.darby@ahrq.hhs.gov
UR - valentinen@who.int
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06392-009
AN - 2008-06392-009
AU - Soldin, Offie P.
AU - Tonning, Joseph M.
T1 - Serotonin syndrome and triptan monotherapy.
JF - The New England Journal of Medicine
JO - The New England Journal of Medicine
JA - N Engl J Med
Y1 - 2008/05//
VL - 358
IS - 20
SP - 2185
EP - 2186
CY - US
PB - Massachusetts Medical Society
SN - 0028-4793
SN - 1533-4406
AD - Soldin, Offie P., Georgetown University Medical Center, Washington, DC, US, 20057
N1 - Accession Number: 2008-06392-009. PMID: 18480219 Other Journal Title: Boston Medical & Surgical Journal. Partial author list: First Author & Affiliation: Soldin, Offie P.; Georgetown University Medical Center, Washington, DC, US. Institutional Authors: Obstetric-Fetal Pharmacology Research Unit Network. Release Date: 20080728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Therapy; Serotonin; Serotonin Norepinephrine Reuptake Inhibitors; Serotonin Reuptake Inhibitors; Syndromes. Minor Descriptor: Triptans. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: May, 2008.
AB - Triptans are serotonin-receptor agonists used in the treatment of migraine headaches. When administered in combination with certain drugs, such as selective serotonin-reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), triptans may precipitate the serotonin syndrome, a potentially life-threatening condition characterized by a triad of clinical manifestations--changes in mental status, autonomic hyperactivity, and neuromuscular abnormalities. The cause of the serotonin syndrome is related to altered serotonin synthesis, release, reuptake, metabolism, or receptor agonism. The serotonin syndrome is a rare but potentially serious occurrence with triptan monotherapy. Because of the spontaneous and voluntary nature of AERS reporting, the actual number of occurrences may be higher, and the risk of the serotonin syndrome among triptan users cannot be established. If symptoms of the serotonin syndrome occur, treatment should be withdrawn, and patients should seek medical attention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serotonin syndrome
KW - triptan monotherapy
KW - selective serotonin reuptake inhibitors
KW - serotonin norepinephrine reuptake inhibitors
KW - 2008
KW - Drug Therapy
KW - Serotonin
KW - Serotonin Norepinephrine Reuptake Inhibitors
KW - Serotonin Reuptake Inhibitors
KW - Syndromes
KW - Triptans
KW - 2008
U1 - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Grant: 5U10HDQ4789Q-03. Recipients: No recipient indicated
U1 - Sponsor: Office of Research on Women's Health. Recipients: No recipient indicated
DO - 10.1056/NEJMc0706410
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06392-009&site=ehost-live&scope=site
UR - os35@georgetown.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Sutherland, A.
AU - Izurieta, H.
AU - Ball, R.
AU - Braun, M. M.
AU - Miller, E. R.
AU - Broder, K. R.
AU - Slade, B. A.
AU - Iskander, J. K.
AU - Kroger, A. T.
AU - Markowitz, L. E.
AU - Huang, W. T.
T1 - Syncope After Vaccination -- United States, January 2005-July 2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/05/02/
VL - 57
IS - 17
M3 - Article
SP - 457
EP - 460
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article reports on medical cases of postvaccination syncope in adolescents in the U.S. from January 2005 to July 2007. Analyses were done by the Centers for Disease Control and Prevention and the Food and Drug Administration using data from the Vaccine Adverse Event Reporting System. Details on the number of postvaccination episodes by selected characteristics are presented. Also noted are the four limitations of the analyses.
KW - SYNCOPE (Pathology)
KW - LOSS of consciousness
KW - TEENAGERS
KW - YOUTH
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 31929426; Sutherland, A. 1 Izurieta, H. 1 Ball, R. 1 Braun, M. M. 1 Miller, E. R. 2 Broder, K. R. 2 Slade, B. A. 2 Iskander, J. K. 2 Kroger, A. T. 3 Markowitz, L. E. 4 Huang, W. T. 5; Affiliation: 1: Div of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Admin. 2: Immunization Safety Office, Office of the Chief Science Officer 3: Immunization Svcs Div, National Center for Immunization and Respiratory Diseases 4: Div of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 5: EIS Officer; Source Info: 5/2/2008, Vol. 57 Issue 17, p457; Subject Term: SYNCOPE (Pathology); Subject Term: LOSS of consciousness; Subject Term: TEENAGERS; Subject Term: YOUTH; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rümke, Hans C.
AU - Bayas, José-María
AU - de Juanes, José-Ramón
AU - Caso, Covadonga
AU - Richardus, Jan Hendrik
AU - Campins, Magda
AU - Rombo, Lars
AU - Duval, Xavier
AU - Romanenko, Viktor
AU - Schwarz, Tino F.
AU - Fassakhov, Rustem
AU - Abad-Santos, Francisco
AU - von Sonnenburg, Frank
AU - Dramé, Mamadou
AU - Sänger, Roland
AU - Ballou, W. Ripley
T1 - Safety and reactogenicity profile of an adjuvanted H5N1 pandemic candidate vaccine in adults within a phase III safety trial
JO - Vaccine
JF - Vaccine
Y1 - 2008/05/02/
VL - 26
IS - 19
M3 - Article
SP - 2378
EP - 2388
SN - 0264410X
AB - Summary: A multicentre, randomized, phase III clinical trial in 5071 healthy adults was conducted to evaluate the safety and reactogenicity of a 15μg HA dose of a candidate oil-in-water emulsion-based adjuvant system (AS)-adjuvanted split-virion H5N1 (AS-H5N1) vaccine compared to a licensed seasonal influenza vaccine, Fluarix™. 1 [1] Fluarix™ is a trademark of GlaxoSmithKline group of companies. Stringent criteria were used to evaluate adverse events and reactogenicity profile. Overall, 96.7% of the 5071 vaccinated subjects completed the study. Significantly more participants in the AS-H5N1 vaccine group reported general or local adverse events. Pain was the most common symptom in both treatment groups. Less than 1% of subjects withdrew from the study due to adverse events and no withdrawals were due to serious adverse events related to vaccination. The safety and reactogenicity profile of the AS-H5N1 candidate vaccine can be considered clinically acceptable in the context of its use against pandemic influenza. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Preventive medicine
KW - Respiratory infections
KW - Medical experimentation on humans
KW - Adjuvanted vaccine
KW - H5N1 pandemic influenza
KW - Phase III clinical trial
KW - Safety
N1 - Accession Number: 31917942; Rümke, Hans C. 1; Email Address: rumke@vaxinostics.com; Bayas, José-María 2; de Juanes, José-Ramón 3; Caso, Covadonga 4; Richardus, Jan Hendrik 5; Campins, Magda 6; Rombo, Lars 7; Duval, Xavier 8; Romanenko, Viktor 9; Schwarz, Tino F. 10; Fassakhov, Rustem 11; Abad-Santos, Francisco 12; von Sonnenburg, Frank 13; Dramé, Mamadou 14; Sänger, Roland 14; Ballou, W. Ripley 14; Affiliations: 1: VAXINOSTICS BV, University Vaccine Center Rotterdam Nijmegen, Beursplein 37, PO Box 30142, 3001 DC Rotterdam, The Netherlands; 2: Hospital Clinic, Barcelona, Spain; 3: Hospital 12 de Octubre, Madrid, Spain; 4: Hospital Clínico San Carlos, Madrid, Spain; 5: Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands; 6: Hospital Vall d’Hebron, Pso. Vall d’Hebron 119-129, 08035 Barcelona, Spain; 7: Infektionskliniken, Mälarsjukhuset, Eskilstuna, Sweden; 8: Centre d’Investigation Clinique, Hôpital Bichat Claude Bernard, 75018 Paris, France; 9: City Children's Hospital N40, Ekaterinburg, Russian Federation; 10: Stiftung Juliusspital, Würzburg, Germany; 11: Kazan Research Institute of Epidemiology and Microbiology, Kazan, Russian Federation; 12: Hospital de La Princesa, Madrid, Spain; 13: Ludwig Maximilians Universität, München, Germany; 14: GlaxoSmithKline Biologicals, Rixensart, Belgium; Issue Info: May2008, Vol. 26 Issue 19, p2378; Thesaurus Term: Vaccination; Subject Term: Preventive medicine; Subject Term: Respiratory infections; Subject Term: Medical experimentation on humans; Author-Supplied Keyword: Adjuvanted vaccine; Author-Supplied Keyword: H5N1 pandemic influenza; Author-Supplied Keyword: Phase III clinical trial; Author-Supplied Keyword: Safety; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.02.068
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31917942&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chang, Soju
AU - Ball, Robert
AU - Braun, M. Miles
T1 - Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990–2006
JO - Vaccine
JF - Vaccine
Y1 - 2008/05/02/
VL - 26
IS - 19
M3 - Article
SP - 2428
EP - 2432
SN - 0264410X
AB - Summary: Generally, live-virus vaccines are contraindicated for pregnant women because of the theoretical risk of transmission of the vaccine virus to the fetus. Advisory groups recommend avoiding pregnancy in the immediate period after administration of such contraindicated vaccines (CVs) and stress benefit-to-risk evaluation for live or inactivated vaccines regarding pregnancy. Given the limited available data and theoretical risks associated particularly with live-virus vaccines, inadvertent immunization with CVs may lead to elective termination of pregnancy (ETP), despite advisory group statements that “vaccination is not ordinarily an indication to terminate the pregnancy.” The Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance system managed by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC), accepts reports of adverse events after vaccination. The objectives of this review were to describe reports of ETP in VAERS and characterize the circumstances of inadvertent administration of vaccines to pregnant women among ETP reports. We reviewed VAERS reports of ETP submitted from 1990 to 2006. Reports of ETP for reasons other than vaccination during or shortly before pregnancy, such as fetal abnormalities or deaths, were excluded. Of 80 ETP reports, 62 (78%) originated from the US; 79 (99%) were reported by manufacturers. Median age of vaccinees was 26 years (range: 13–43 years; 67 reports). Seventy-three vaccinees (91%) received a single vaccine; 65 (81%) received at least one live-virus vaccine. In 48 (60%) ETP reports, vaccinees were unaware of pregnancy at time of immunization. In 15 (19%) reports, vaccinees became pregnant within 3 months of vaccination; in 13 (16%) reports, vaccinees might have been pregnant before vaccination; in 4 (5%) reports, information was missing. All 80 reports of ETP involved vaccines for which possible effects on fetal development are unknown. However, no cases of vaccine-associated congenital rubella or varicella syndromes have been reported in the medical literature. Also, these syndromes have not been reported to varicella or rubella vaccine pregnancy registries. VAERS has the limitations of passive surveillance systems. Under-reporting of ETP in VAERS could be substantial. More attention may be needed to assess the likelihood of pregnancy when administering vaccines to women with child-bearing potential, and to inform women who learn they are pregnant shortly after being immunized of current information on risks. Quantifying the frequency of ETP related to CVs and the risk (if any) to the fetus of such vaccines can help to inform policy, practice, and individual decision making. Good quality information may be obtained from controlled observational studies. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - Reproduction
KW - Communicable diseases -- Transmission
KW - Vaccines
KW - Elective termination of pregnancy
KW - Vaccine
KW - VAERS
N1 - Accession Number: 31917947; Chang, Soju; Email Address: soju.chang@fda.hhs.gov; Ball, Robert 1; Braun, M. Miles 1; Affiliations: 1: Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM-222, Rockville, MD 20852 United States; Issue Info: May2008, Vol. 26 Issue 19, p2428; Thesaurus Term: Vaccination; Thesaurus Term: Reproduction; Thesaurus Term: Communicable diseases -- Transmission; Subject Term: Vaccines; Author-Supplied Keyword: Elective termination of pregnancy; Author-Supplied Keyword: Vaccine; Author-Supplied Keyword: VAERS; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.02.052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31917947&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xia, Qingsu
AU - Yan, Jian
AU - Chou, Ming W.
AU - Fu, Peter P.
T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2008/05/05/
VL - 178
IS - 2
M3 - Article
SP - 77
EP - 82
SN - 03784274
AB - Abstract: Pyrrolizidine alkaloid-containing plants are widespread in the world and may be the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolism to exert their genotoxicity and tumorigenicity. Our mechanistic studies have determined that metabolism of the retronecine-type (riddelliine, retrorsine, and monocrotaline), heliotridine-type (lasiocarpine), and otonecine-type (clivorine) tumorigenic pyrrolizidine alkaloids in vivo and/or in vitro all generates a common set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts responsible for tumor induction. All the pyrrolizidine alkaloids studied previously are diesters with an ester linkage at the C7 and C9 positions of the necine base. In this study, we report that F344 rat liver microsomal metabolism of heliotrine, a tumorigenic monoester bearing a hydroxyl group at the C7 of the necine base, resulted in the formation of the dehydroheliotridine (DHH) metabolite. When incubations of heliotrine were carried out in the presence of calf thymus DNA, the same set of DHP-derived DNA adducts was formed. These results support that DHP-derived DNA adducts are potential common biomarkers of pyrrolizidine alkaloid exposure and tumorigenicity. For comparison, the dehydroretronecine (DHR)-derived DNA adducts formed from metabolism of riddleiine, retrorsine, monocrotaline, riddelleiine N-oxide, and retrorsine N-oxide were measured in parallel; the levels of DHP-derived DNA adduct formation were in the order: riddelliine≈retrorsine>monocrotaline>retrorsine N-oxide≥riddelliine N-oxide>heliotrine. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - Methanol
KW - Biochemical markers
KW - Nucleotides
KW - (+/−)6
KW - (+/−)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHP )
KW - 2′-deoxyguanosine-3′-monophosphate ( 3′-dGMP )
KW - 3′
KW - 3′,5′-bisphosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′,5′-dG-bisphosphate adducts (I and II) )
KW - 3′-monophosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′-dGMP adducts (I and II) )
KW - 5′-bisphosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′
KW - 5′-dG-bisphosphate adducts (I and II) )
KW - 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHH )
KW - 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHP )
KW - 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHR )
KW - adenosine 5′-triphosphate ( ATP )
KW - cloned T4 polynucleotide kinase ( PNK )
KW - Dehydroheliotridine (DHH)
KW - dehydroheliotridine or (+)S-6
KW - dehydroheliotridine or (+)S-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHH )
KW - dehydroretronecine or (−)R-6
KW - dehydroretronecine or (−)R-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHR )
KW - DNA adducts
KW - Heliotrine
KW - micrococcal nuclease ( MN )
KW - National Center for Toxicological Research ( NCTR )
KW - Pyrrolizidine alkaloid
KW - spleen phosphodiesterase ( SPD )
N1 - Accession Number: 31921514; Xia, Qingsu 1; Yan, Jian 1; Chou, Ming W. 1; Fu, Peter P.; Email Address: peter.fu@fda.hhs.gov; Affiliations: 1: National Center for Toxicological Research, Jefferson, AR 72079, United States; Issue Info: May2008, Vol. 178 Issue 2, p77; Thesaurus Term: Nucleic acids; Thesaurus Term: Methanol; Thesaurus Term: Biochemical markers; Subject Term: Nucleotides; Author-Supplied Keyword: (+/−)6; Author-Supplied Keyword: (+/−)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHP ); Author-Supplied Keyword: 2′-deoxyguanosine-3′-monophosphate ( 3′-dGMP ); Author-Supplied Keyword: 3′; Author-Supplied Keyword: 3′,5′-bisphosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′,5′-dG-bisphosphate adducts (I and II) ); Author-Supplied Keyword: 3′-monophosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′-dGMP adducts (I and II) ); Author-Supplied Keyword: 5′-bisphosphate of 7-(deoxyguanosin-N 2-yl)DHP ( DHP-3′; Author-Supplied Keyword: 5′-dG-bisphosphate adducts (I and II) ); Author-Supplied Keyword: 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHH ); Author-Supplied Keyword: 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHP ); Author-Supplied Keyword: 7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHR ); Author-Supplied Keyword: adenosine 5′-triphosphate ( ATP ); Author-Supplied Keyword: cloned T4 polynucleotide kinase ( PNK ); Author-Supplied Keyword: Dehydroheliotridine (DHH); Author-Supplied Keyword: dehydroheliotridine or (+)S-6; Author-Supplied Keyword: dehydroheliotridine or (+)S-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHH ); Author-Supplied Keyword: dehydroretronecine or (−)R-6; Author-Supplied Keyword: dehydroretronecine or (−)R-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine ( DHR ); Author-Supplied Keyword: DNA adducts; Author-Supplied Keyword: Heliotrine; Author-Supplied Keyword: micrococcal nuclease ( MN ); Author-Supplied Keyword: National Center for Toxicological Research ( NCTR ); Author-Supplied Keyword: Pyrrolizidine alkaloid; Author-Supplied Keyword: spleen phosphodiesterase ( SPD ); NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.toxlet.2008.02.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31921514&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Han, Beom Seok
AU - Ahn, Byeongwoo
AU - Nam, Ki Taek
AU - Choi, Mina
AU - Oh, Sang Yeon
AU - Kim, Seung Hee
AU - Jeong, Jayoung
AU - Jang, Dong Deuk
T1 - Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2008/05/05/
VL - 178
IS - 2
M3 - Article
SP - 110
EP - 116
SN - 03784274
AB - Abstract: Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-α activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Rats
KW - Anthropometry
KW - Urinary organs
KW - Biliary tract
KW - Carcinogenicity
KW - Di-isodecyl phthalate (DIDP)
KW - F344 rats
KW - Feed study
KW - Liver
KW - Peroxisome proliferator
N1 - Accession Number: 31921519; Cho, Wan-Seob 1; Han, Beom Seok 1; Ahn, Byeongwoo 2; Nam, Ki Taek 1; Choi, Mina 1; Oh, Sang Yeon 1; Kim, Seung Hee 1; Jeong, Jayoung 1; Jang, Dong Deuk 1; Email Address: ddjang@kfda.go.kr; Affiliations: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; 2: Department of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Chungbuk 361-763, Republic of Korea; Issue Info: May2008, Vol. 178 Issue 2, p110; Subject Term: Rats; Subject Term: Anthropometry; Subject Term: Urinary organs; Subject Term: Biliary tract; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Di-isodecyl phthalate (DIDP); Author-Supplied Keyword: F344 rats; Author-Supplied Keyword: Feed study; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Peroxisome proliferator; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxlet.2008.02.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=31921519&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Lin, Kenneth W.
T1 - Study's conclusion about screening is unwarranted.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2008/05/10/
VL - 336
IS - 7652
M3 - Letter
SP - 1034
EP - 1034
SN - 09598146
AB - A letter to the editor is presented in response to the article "Effect On Smoking Quit Rate of Telling Patients Their Lung Age: the Step2Quit Randomised Controlled Trial" by G. Parkes, T. Greenhalgh, M. Griffin and R. Dent in the March 15, 2008 issue.
KW - LETTERS to the editor
KW - SMOKING cessation
N1 - Accession Number: 32093410; Lin, Kenneth W. 1; Affiliation: 1: Medical Officer, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA; Source Info: 5/10/2008, Vol. 336 Issue 7652, p1034; Subject Term: LETTERS to the editor; Subject Term: SMOKING cessation; NAICS/Industry Codes: 621990 All other ambulatory health care services; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 1/6p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wells, C.
AU - Thomas, D.
T1 - Deaths in the dental surgery: individual and organisational criminal liability.
JO - British Dental Journal
JF - British Dental Journal
Y1 - 2008/05/10/
VL - 204
IS - 9
M3 - Article
SP - 497
EP - 502
SN - 00070610
AB - This paper is intended to update dental practitioners and commissioners of dental services on the significance of the Corporate Manslaughter and Corporate Homicide Act 2007 which came into force in April 2008. The paper places the Act in the context of the potential criminal (as opposed to civil) liabilities of dental providers. It looks in detail at criminal liability, health and safety and gross negligence manslaughter. In particular it explains the essential elements of the new offence: the threshold question of which organisations are covered, the relevant duty of care, when an organisation may be culpable, and what penalties they may face on conviction. The paper concludes that any dental provider may be liable for one of these offences (health and safety, gross negligence manslaughter or the new corporate manslaughter offence) but only a limited number is likely ever to find themselves answering a criminal charge. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Dental Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTISTRY -- Practice
KW - DEATH
KW - DENTAL personnel
KW - CRIMINAL liability
KW - MEDICAL laws & legislation
N1 - Accession Number: 31965681; Wells, C. 1 Thomas, D. 2; Email Address: david.thomas@nphs.wales.nhs.uk; Affiliation: 1: Professor of Law, Durham University, 30 Old Elvet, Durham DH1 3BN 2: Consultant in Dental Public Health, National Public Health Service, Mamhilad House, Mamhilad Park Estate, Pontypool NP4 0YP; Source Info: 5/10/2008, Vol. 204 Issue 9, p497; Subject Term: DENTISTRY -- Practice; Subject Term: DEATH; Subject Term: DENTAL personnel; Subject Term: CRIMINAL liability; Subject Term: MEDICAL laws & legislation; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 6p; Document Type: Article
L3 - 10.1038/sj.bdj.2008.349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31965681&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hsieh, Szu-Chia
AU - Liu, I-Jung
AU - King, Chwan-Chuen
AU - Chang, Gwong-Jen
AU - Wang, Wei-Kung
T1 - A strong endoplasmic reticulum retention signal in the stem–anchor region of envelope glycoprotein of dengue virus type 2 affects the production of virus-like particles
JO - Virology
JF - Virology
Y1 - 2008/05/10/
VL - 374
IS - 2
M3 - Article
SP - 338
EP - 350
SN - 00426822
AB - Abstract: Recombinant virus-like particles (VLPs) of flaviviruses have been shown to be produced efficiently by co-expressing the precursor membrane (PrM) and envelope (E) proteins with few exceptions, such as dengue virus type 2 (DENV2). It was reported previously that chimeric DENV2 PrM/E construct containing the stem–anchor region of E protein of Japanese encephalitis virus (JEV) produced VLPs efficiently (Chang, G. J., Hunt, A. R., Holmes, D. A., Springfield, T., Chiueh, T. S., Roehrig, J. T., and Gubler, D. J. 2003. Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus. Virology 306, 170–180.). We investigated the mechanisms involved and reported that compared with authentic DENV2 PrM/E-expressing cells, E protein in chimeric DENV2 PrM/E-expressing cells was also present in an endoglycosidase H (endo H)-resistant compartment and has shifted more to the pellets of the soluble fraction. Replacement of the transmembrane and cytoplasmic domains of CD4 with the stem–anchor of DENV2 (CD4D2) or JEV (CD4JEV) rendered the chimeric CD4 retained predominantly in the endoplasmic reticulum (ER). Flow cytometry revealed higher proportion of CD4JEV than CD4D2 expressed on the cell surface. Together, these findings suggested that the stem–anchor of DENV2 contained an ER retention signal stronger than that of JEV, which might contribute to the inefficient production of DENV2 VLPs. Moreover, co-expression of C protein can enhance the production of DENV2 VLPs, suggesting a mechanism of facilitating viral particle formation during DENV2 replication. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE viruses
KW - ENCEPHALITIS
KW - BIOLOGICAL transport
KW - MOBILE genetic elements
KW - VIROLOGY
KW - Dengue virus
KW - Endoplasmic reticulum
KW - Stem–anchor region
KW - Virus-like particles
N1 - Accession Number: 31896118; Hsieh, Szu-Chia 1 Liu, I-Jung 2,3 King, Chwan-Chuen 4 Chang, Gwong-Jen 5 Wang, Wei-Kung 1,2; Email Address: wwang60@yahoo.com; Affiliation: 1: Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan 2: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 3: Cardinal Tien College of Healthcare and Management, Taipei, Taiwan 4: Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 5: Division of Vector-Borne Infectious Diseases, Center for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Service, Fort Collins, Colorado, USA; Source Info: May2008, Vol. 374 Issue 2, p338; Subject Term: DENGUE viruses; Subject Term: ENCEPHALITIS; Subject Term: BIOLOGICAL transport; Subject Term: MOBILE genetic elements; Subject Term: VIROLOGY; Author-Supplied Keyword: Dengue virus; Author-Supplied Keyword: Endoplasmic reticulum; Author-Supplied Keyword: Stem–anchor region; Author-Supplied Keyword: Virus-like particles; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.virol.2007.12.041
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Faustino, Patrick J.
AU - Yang, Yongsheng
AU - Progar, Joseph J.
AU - Brownell, Charles R.
AU - Sadrieh, Nakissa
AU - May, Joan C.
AU - Leutzinger, Eldon
AU - Place, David A.
AU - Duffy, Eric P.
AU - Houn, Florence
AU - Loewke, Sally A.
AU - Mecozzi, Vincent J.
AU - Ellison, Christopher D.
AU - Khan, Mansoor A.
AU - Hussain, Ajaz S.
AU - Lyon, Robbe C.
T1 - Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/05/12/
VL - 47
IS - 1
M3 - Article
SP - 114
EP - 125
SN - 07317085
AB - Abstract: Ferric hexacyanoferrate (Fe4III[FeII(CN)6]3), also known as insoluble Prussian blue (PB) is the active pharmaceutical ingredient (API) of the drug product, Radiogardase®. Radiogardase® is the first FDA approved medical countermeasure for the treatment of internal contamination with radioactive cesium (Cs) or thallium in the event of a major radiological incident such as a “dirty bomb”. A number of pre-clinical and clinical studies have evaluated the use of PB as an investigational decorporation agent to enhance the excretion of metal cations. There are few sources of published in vitro data that detail the binding capacity of cesium to insoluble PB under various chemical and physical conditions. The study objective was to determine the in vitro binding capacity of PB APIs and drug products by evaluating certain chemical and physical factors such as medium pH, particle size, and storage conditions (temperature). In vitro experimental conditions ranged from pH 1 to 9, to cover the range of pH levels that PB may encounter in the gastrointestinal (GI) tract in humans. Measurements of cesium binding were made between 1 and 24h, to cover gastric and intestinal tract residence time using a validated atomic emission spectroscopy (AES) method. The results indicated that pH, exposure time, storage temperature (affecting moisture content) and particle size play significant roles in the cesium binding to both the PB API and the drug product. The lowest cesium binding was observed at gastric pH of 1 and 2, whereas the highest cesium binding was observed at physiological pH of 7.5. It was observed that dry storage conditions resulted in a loss of moisture from PB, which had a significant negative effect on the PB cesium binding capacity at time intervals consistent with gastric residence. Differences were also observed in the binding capacity of PB with different particle sizes. Significant batch to batch differences were also observed in the binding capacity of some PB API and drug products. Our results suggest that certain physiochemical properties affect the initial binding capacity and the overall binding capacity of PB APIs and drug products during conditions that simulated gastric and GI residence time. These physiochemical properties can be utilized as quality attributes to monitor and predict drug product quality under certain manufacturing and storage conditions and may be utilized to enhance the clinical efficacy of PB. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CESIUM
KW - PRUSSIAN blue
KW - MOISTURE
KW - ATOMIC emission spectroscopy
KW - Atomic emission spectroscopy
KW - Cesium binding
KW - GI model
KW - Moisture
KW - Particle size
KW - pH-profile
KW - Product quality
KW - Prussian blue
N1 - Accession Number: 31677940; Faustino, Patrick J. 1; Email Address: patrick.faustino@fda.hhs.gov Yang, Yongsheng 1 Progar, Joseph J. 2 Brownell, Charles R. 1 Sadrieh, Nakissa 3 May, Joan C. 2 Leutzinger, Eldon 4 Place, David A. 4 Duffy, Eric P. 4 Houn, Florence 2 Loewke, Sally A. 5 Mecozzi, Vincent J. 1 Ellison, Christopher D. 1 Khan, Mansoor A. 1 Hussain, Ajaz S. 3 Lyon, Robbe C. 1; Affiliation: 1: Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 2: Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, United States 3: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Building-21, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 4: Office of New Drug Quality Assurance, Center for Drug Evaluation and Research, Food and Drug Administration, Building-22, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States 5: Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Building-21, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States; Source Info: May2008, Vol. 47 Issue 1, p114; Subject Term: CESIUM; Subject Term: PRUSSIAN blue; Subject Term: MOISTURE; Subject Term: ATOMIC emission spectroscopy; Author-Supplied Keyword: Atomic emission spectroscopy; Author-Supplied Keyword: Cesium binding; Author-Supplied Keyword: GI model; Author-Supplied Keyword: Moisture; Author-Supplied Keyword: Particle size; Author-Supplied Keyword: pH-profile; Author-Supplied Keyword: Product quality; Author-Supplied Keyword: Prussian blue; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.jpba.2007.11.049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chandler, Chris
AU - Gryniewicz, Connie M.
AU - Pringle, Tom
AU - Cunningham, Fran
T1 - Insulin temperature and stability under simulated transit conditions.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2008/05/15/
VL - 65
IS - 10
M3 - Article
SP - 953
EP - 963
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The transit temperature profiles, mean kinetic temperatures (MKTs), and stability of insulin samples in both insulated and noninsulated containers exposed to summer and winter temperatures were evaluated. Methods. Regular insulin, isophane insulin human (NPH) insulin, and 70% isophane-30% regular (70/30) insulin were packaged in the most commonly dispensed quantity of four vials in noninsulated mailers and insulated containers with frozen gel packs. After packaging, sealed containers and mailers were placed in an environmental chamber for 24–120 hours and exposed to summer and winter transit conditions. Temperatures inside the environmental chamber were recorded every 15 minutes and maintained within 3 °C of the specified transit temperature. After exposure to the transit conditions, insulin cartons were removed from their packaging, visually inspected for changes in physical appearance, and stored at 4 °C until analysis. The MKT of each package was calculated. High-performance liquid chromatography was performed to determine sample stability, and size-exclusion chromatography was conducted to detect aggregate products of insulin. Results. Regardless of shipping conditions or packaging, all samples met the United States Pharmacopeia's (USP's) specified limits and retained product stability. Visual inspection of the physical appearance of insulin samples before and after temperature exposure revealed results similar to those described in the product inserts. Microscopic analysis of the injectable suspensions confirmed similar crystal morphologies before and after temperature exposure. Conclusion. Regular, NPH, and 70/30 insulin maintained potency within USP limits when stored in programmable environmental chambers simulating summer and winter overnight or three- to five-day ground delivery conditions, regardless of packaging material. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSULIN
KW - DRUGS -- Packaging
KW - PHYSICAL distribution of goods
KW - HYPOGLYCEMIC agents
KW - UNITED States
KW - Control
KW - Insulin human
KW - Insulin human isophane
KW - Insulins
KW - Packaging
KW - quality
KW - Stability
KW - Storage
KW - Temperature
KW - Transportation
N1 - Accession Number: 32428914; Chandler, Chris 1; Email Address: chris.chandler@va.gov Gryniewicz, Connie M. 2 Pringle, Tom 3 Cunningham, Fran 4,5; Affiliation: 1: Quality Assurance Specialist, Department of Veterans Affairs Great Lakes Consolidated Mail Outpatient Pharmacy, 5th and Roosevelt Road, Building 37 NW, Hines, IL 60141 2: Analyst and Chemist, Division of Pharmaceutical Analysis, Food and Drug Administration, St. Louis, MO 3: Acting Technical Director, Tegrant Diversified Brands Inc., ThermoSafe Brands, Phoenix, AZ 4: Director, Center for Medication Safety, Patient Safety Center of Inquiry 5: Program Manager, Pharmacoepidemiologic/Outcomes Research, Department of Veterans Affairs Pharmacy Benefits Management/Strategic Healthcare Group, Hines; Source Info: 5/15/2008, Vol. 65 Issue 10, p953; Subject Term: INSULIN; Subject Term: DRUGS -- Packaging; Subject Term: PHYSICAL distribution of goods; Subject Term: HYPOGLYCEMIC agents; Subject Term: UNITED States; Author-Supplied Keyword: Control; Author-Supplied Keyword: Insulin human; Author-Supplied Keyword: Insulin human isophane; Author-Supplied Keyword: Insulins; Author-Supplied Keyword: Packaging; Author-Supplied Keyword: quality; Author-Supplied Keyword: Stability; Author-Supplied Keyword: Storage; Author-Supplied Keyword: Temperature; Author-Supplied Keyword: Transportation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 11p; Illustrations: 3 Color Photographs, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.2146/ajhp070347
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vora, Surabhi
AU - Damon, Inger
AU - Fulginiti, Vincent
AU - Weber, Stephen G.
AU - Kahana, Madelyn
AU - Stein, Sarah L.
AU - Gerber, Susan I.
AU - Garcia-Houchins, Sylvia
AU - Lederman, Edith
AU - Hruby, Dennis
AU - Collins, Limone
AU - Scott, Dorothy
AU - Thompson, Kenneth
AU - Barson, John V.
AU - Regnery, Russell
AU - Hughes, Christine
AU - Daum, Robert S.
AU - Yu Li
AU - Hui Zhao
AU - Smith, Scott
T1 - Severe Eczema Vaccinatum in a Household Contact of a Smallpox Vaccinee.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/05/15/
VL - 46
IS - 10
M3 - Article
SP - 1555
EP - 1561
SN - 10584838
AB - Background. We report the first confirmed case of eczema vaccinatum in the United States related to smallpox vaccination since routine vaccination was discontinued in 1972. A 28-month-old child with refractory atopic dermatitis developed eczema vaccinatum after exposure to his father, a member of the US military who had recently received smallpox vaccine. The father had a history of inactive eczema but reportedly reacted normally to the vaccine. The child's mother also developed contact vaccinia infection. Methods. Treatment of the child included vaccinia immune globulin administered intravenously, used for the first time in a pediatric patient; cidofovir, never previously used for human vaccinia infection; and ST-246, an investigational agent being studied for the treatment of orthopoxvirus infection. Serological response to vaccinia virus and viral DNA levels, correlated with clinical events, were utilized to monitor the course of disease and to guide therapy. Burn patient—type management was required, including skin grafts. Results. The child was discharged from the hospital after 48 days and has recovered with no apparent systemic sequelae or significant scarring. Conclusion. This case illustrates the need for careful screening prior to administration of smallpox vaccine and awareness by clinicians of the ongoing vaccination program and the potential risk for severe adverse events related to vaccinia virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immunization
KW - Eczema
KW - Skin -- Inflammation
KW - Eczema in children
KW - Pompholyx (Disease)
KW - Immunization of children
KW - Preventive medicine
KW - Atopic dermatitis
KW - Medical care
N1 - Accession Number: 31779099; Vora, Surabhi 1; Email Address: sbhargav@uchicago.edu; Damon, Inger 2; Fulginiti, Vincent 3,4; Weber, Stephen G. 1,5; Kahana, Madelyn 6; Stein, Sarah L. 7; Gerber, Susan I. 8; Garcia-Houchins, Sylvia 5; Lederman, Edith 2; Hruby, Dennis 9; Collins, Limone 10; Scott, Dorothy 11; Thompson, Kenneth 12; Barson, John V. 13; Regnery, Russell 2; Hughes, Christine 2; Daum, Robert S. 1; Yu Li 2; Hui Zhao 2; Smith, Scott 2; Affiliations: 1: Section of Infectious Diseases, University of Chicago Medical Center; 2: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; 3: University of Arizona, Tucson; 4: University of Colorado, Denver; 5: Section of Infection Control Program, University of Chicago Medical Center; 6: Section of Critical Care, Department of Pediatrics, University of Chicago Medical Center; 7: Section of Dermatology, University of Chicago Medical Center; 8: Chicago Department of Public Health, Chicago, Illinois; 9: SIGA Technologies, Corvallis, Oregon; 10: Vaccine Healthcare Centers Network, Department of Defense, Washington, D.C.; 11: US Food and Drug Administration, Washington, D.C.; 12: Department of Pathology, University of Chicago Medical Center; 13: Division of Bioterrorism Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia; Issue Info: 5/15/2008, Vol. 46 Issue 10, p1555; Thesaurus Term: Immunization; Subject Term: Eczema; Subject Term: Skin -- Inflammation; Subject Term: Eczema in children; Subject Term: Pompholyx (Disease); Subject Term: Immunization of children; Subject Term: Preventive medicine; Subject Term: Atopic dermatitis; Subject Term: Medical care; Number of Pages: 7p; Illustrations: 4 Color Photographs, 3 Graphs; Document Type: Article
L3 - 10.1086/587668
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Chan-Tack, Kirk M.
AU - Murray, Jeffrey S.
T1 - Antiviral Therapy and Outcomes in Hospitalized Patients with Influenza.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/05/15/
VL - 46
IS - 10
M3 - Letter
SP - 1628
EP - 1629
SN - 10584838
AB - A letter to the editor is presented in response to the article about antiviral treatment that might reduce mortality among hospitalized patients, which appeared in the previous issue.
KW - Letters to the editor
KW - Hospital patients
N1 - Accession Number: 31779079; Chan-Tack, Kirk M. 1; Email Address: kirk.chan-tack@fda.hhs.gov; Murray, Jeffrey S. 1; Affiliations: 1: Division of Antiviral Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland; Issue Info: 5/15/2008, Vol. 46 Issue 10, p1628; Subject Term: Letters to the editor; Subject Term: Hospital patients; Number of Pages: 2p; Document Type: Letter
L3 - 10.1086/587751
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Dougherty, Denise
AU - Conway, Patrick H.
T1 - The "3T's" Road Map to Transform US Health Care.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/05/21/
VL - 299
IS - 19
M3 - Editorial
SP - 2319
EP - 2321
SN - 00987484
AB - The authors comments on issues surrounding the failure of the U.S. health care system to deliver high-quality medical care and improved health outcomes by leveraging clinical discoveries and technological advancements in a timely manner. Accelerating the delivery of quality care across all levels of the health care system by instituting three translation (3T) steps is discussed. Each of the 3T steps are defined. The leadership, tools, and resources needed to facilitate the 3T road map are examined.
KW - MEDICAL care -- Quality control
KW - MEDICAL innovations
KW - OUTCOME assessment (Medical care)
KW - HEALTH services administration
KW - UNITED States
N1 - Accession Number: 32108055; Dougherty, Denise 1 Conway, Patrick H. 1,2; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: Center for Health Care Quality, Division of Health Policy and Clinical Effectivemenss, and Division of General Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Source Info: 5/21/2008, Vol. 299 Issue 19, p2319; Subject Term: MEDICAL care -- Quality control; Subject Term: MEDICAL innovations; Subject Term: OUTCOME assessment (Medical care); Subject Term: HEALTH services administration; Subject Term: UNITED States; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105546729
T1 - The "3T's" road map to transform US health care: the "how" of high-quality care.
AU - Dougherty D
AU - Conway PH
AU - Dougherty, Denise
AU - Conway, Patrick H
Y1 - 2008/05/21/
N1 - Accession Number: 105546729. Language: English. Entry Date: 20090828. Revision Date: 20161112. Publication Type: journal article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Health Care Reform
KW - Quality of Health Care
KW - Health Care Delivery
KW - Health Services Research
KW - Outcome Assessment
KW - Research, Medical
KW - United States
KW - Human
SP - 2319
EP - 2321
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 299
IS - 19
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, Maryland 20850, USA
AD - Office of Extramural Research, Education, and Priority Populations, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, Maryland 20850, USA. denise.dougherty@ahrq.hhs.gov
U2 - PMID: 18492974.
DO - 10.1001/jama.299.19.2319
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - De Jager, Lowri S.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Analysis of tetramethylene disulfotetramine in foods using solid-phase microextraction–gas chromatography–mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/05/23/
VL - 1192
IS - 1
M3 - Article
SP - 36
EP - 40
SN - 00219673
AB - Abstract: An automated solid-phase microextraction–gas chromatography–mass spectrometry (SPME–GC–MS) method for the determination of tetramethylene disulfotetramine in foods was developed. A comparison of direct immersion (DI) and headspace (HS) extraction techniques using a 70μm carbowax/divinylbenzene (CW/DVB) fiber is presented. The optimized DI-SPME method provided an aqueous extraction limit of detection (LOD) of 9.0ng/g while the HS-SPME LOD was 2.7ng/g. In both SPME modes, recovery was highly matrix dependent and quantification requires standard addition calibrations. Analysis of foods using DI-SPME encountered many obstacles including fiber fouling, low recovery and poor reproducibility. HS-SPME was successfully applied to food analysis with minimal interferences. Standard addition calibration curves for foods gave high linearity (R 2 >0.98), reproducibility (RSD<12%) and sensitivity with LODs ranging from 0.9 to 4.3ng/g. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Analysis
KW - TECHNICAL chemistry
KW - SANITARY chemistry
KW - FLAVOR
KW - Food analysis
KW - Food defense
KW - SPME
KW - Tetramine
KW - TETS
N1 - Accession Number: 31916859; De Jager, Lowri S.; Email Address: lowri.dejager@fda.hhs.gov Perfetti, Gracia A. 1 Diachenko, Gregory W. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, USA; Source Info: May2008, Vol. 1192 Issue 1, p36; Subject Term: FOOD -- Analysis; Subject Term: TECHNICAL chemistry; Subject Term: SANITARY chemistry; Subject Term: FLAVOR; Author-Supplied Keyword: Food analysis; Author-Supplied Keyword: Food defense; Author-Supplied Keyword: SPME; Author-Supplied Keyword: Tetramine; Author-Supplied Keyword: TETS; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.chroma.2008.03.042
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Salmon, Ronald L.
AU - Evans, Meirion R.
AU - Mason, Brendan W.
AU - Werber, Dirk
T1 - Test early for verotoxin producing Escherichia coli.
JO - BMJ: British Medical Journal (International Edition)
JF - BMJ: British Medical Journal (International Edition)
Y1 - 2008/05/24/
VL - 336
IS - 7654
M3 - Letter
SP - 1147
EP - 1148
SN - 09598146
AB - A letter to the editor is presented in response to the article "Management of Bloody Diarrhea in Children in Primary Care" by M. S. Murphy in the May 3, 2008 issue.
KW - LETTERS to the editor
KW - DIARRHEA
N1 - Accession Number: 32468934; Salmon, Ronald L. 1; Email Address: roland.salmon@nphs.wales.nhs.uk Evans, Meirion R. 2 Mason, Brendan W. 2 Werber, Dirk 3; Affiliation: 1: consultant epidemiologist, National Public Health Service for Wales, Temple of Peace and Health, Cardiff CF10 3N W 2: National Public Health Service for Wales, Temple of Peace and Health, Cardiff CF10 3N W 3: Department for Infectious Disease Epidemiology. Robert Koch Institute, Berlin, Germany; Source Info: 5/24/2008, Vol. 336 Issue 7654, p1147; Subject Term: LETTERS to the editor; Subject Term: DIARRHEA; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - Ye, Wei
AU - Ritschel, Wolfgang A.
T1 - Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatography
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2008/05/26/
VL - 616
IS - 1
M3 - Article
SP - 78
EP - 84
SN - 00032670
AB - Abstract: Previously, a method was presented for the analysis of mechlorethamine by derivatization of this unstable nitrogen mustard to bis(2-phenylthioethyl)methylamine (PTEMA), a stable compound suitable for analysis by HPLC with UV detection [J.C. Reepmeyer, J. Chromatogr. A, 1085 (2005) 262]. Mechlorethamine HCl served as a reference standard and it was derivatized in situ simultaneously with samples of mechlorethamine HCl in ointment preparations. This paper presents the synthesis of PTEMA on a gram scale, synthesis of its picrate salt, bis(2-phenylthioethyl)methylamine picrate (PTEMAP), and isolation of the picrate as a crystalline solid. PTEMAP may serve as a reference standard replacing the toxic mechlorethamine HCl. Insights into the handling, storage, drying, and hygroscopic properties of mechlorethamine HCl and PTEMAP are discussed. In addition, one step following the derivatization procedure in the original method is recognized as a potential for error, and a procedure relating to the order of addition of reagents is presented to avoid this error. The method has been extended to the analysis of mechlorethamine in aqueous solutions. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - ANALYTICAL chemistry
KW - BRASSICA
KW - LIQUID chromatography
KW - Analysis
KW - Derivatization
KW - High-performance liquid chromatography
KW - Mechlorethamine
KW - Nitrogen mustard
N1 - Accession Number: 32052959; Reepmeyer, John C. 1; Email Address: reepmeyer@juno.com Ye, Wei 1 Ritschel, Wolfgang A. 2; Affiliation: 1: United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101 USA 2: University of Cincinnati Medical Center, The James L. Winkle College of Pharmacy, Cincinnati, OH 45267 USA; Source Info: May2008, Vol. 616 Issue 1, p78; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ANALYTICAL chemistry; Subject Term: BRASSICA; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Analysis; Author-Supplied Keyword: Derivatization; Author-Supplied Keyword: High-performance liquid chromatography; Author-Supplied Keyword: Mechlorethamine; Author-Supplied Keyword: Nitrogen mustard; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.aca.2008.04.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murphy, Trudy V.
AU - Slade, Barbara A.
AU - Broder, Karen R.
AU - Kretsinger, Katrina
AU - Tiwari, Tejpratap
AU - Joyce, M. Patricia
AU - Iskander, John K.
AU - Brown, Kristin
AU - Moran, John S.
T1 - Prevention of Pertussis, Tetanus, and Diphtheria Among Pregnant and Postpartum Women and Their Infants.
JO - MMWR Recommendations & Reports
JF - MMWR Recommendations & Reports
Y1 - 2008/05/30/
VL - 57
IS - RR-4
M3 - Article
SP - 1
EP - 50
PB - Centers for Disease Control & Prevention (CDC)
SN - 10575987
AB - In 2005, two tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines were licensed and recommended for use in adults and adolescents in the United States: ADACEL® (sanofi pasteur, Swiftwater, Pennsylvania), which is licensed for use in persons aged 11-64 years, and BOOSTRIX® (GlaxoSmithKline Biologicals, Rixensart, Belgium), which is licensed for use in persons aged 10-18 years. Both Tdap vaccines are licensed for single-dose use to add protection against pertussis and to replace the next dose of tetanus and diphtheria toxoids vaccine (Td). Available evidence does not address the safety of Tdap for pregnant women, their fetuses, or pregnancy outcomes sufficiently. Available data also do not indicate whether Tdap-induced transplacental maternal antibodies provide early protection against pertussis to infants or interfere with an infant's immune responses to routinely administered pediatric vaccines. Until additional information is available, CDC's Advisory Committee on Immunization Practices recommends that pregnant women who were not vaccinated previously with Tdap: 1) receive Tdap in the immediate postpartum period before discharge from hospital or birthing center, 2) may receive Tdap at an interval as short as 2 years since the most recent Td vaccine, 3) receive Td during pregnancy for tetanus and diphtheria protection when indicated, or 4) defer the Td vaccine indicated during pregnancy to substitute Tdap vaccine in the immediate postpartum period if the woman is likely to have sufficient protection against tetanus and diphtheria. Although pregnancy is not a contraindication for receiving Tdap vaccine, health-care providers should weigh the theoretical risks and benefits before choosing to administer Tdap vaccine to a pregnant woman. This report 1) describes the clinical features of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants, 2) reviews available evidence of pertussis vaccination during pregnancy as a strategy to prevent infant pertussis, 3) summarizes Tdap vaccination policy in the United States, and 4) presents recommendations for use of Td and Tdap vaccines among pregnant and postpartum women. [ABSTRACT FROM AUTHOR]
AB - Copyright of MMWR Recommendations & Reports is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WHOOPING cough
KW - PREVENTION
KW - TETANUS
KW - DIPHTHERIA
KW - PREGNANT women
KW - PUERPERIUM
KW - INFANTS
N1 - Accession Number: 32653304; Murphy, Trudy V. 1; Email Address: tkm4@cdc.gov Slade, Barbara A. 1 Broder, Karen R. 1,2 Kretsinger, Katrina 1,2 Tiwari, Tejpratap 1 Joyce, M. Patricia 1 Iskander, John K. 2 Brown, Kristin 1 Moran, John S. 1,2; Affiliation: 1: Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases 2: United States Public Health Service; Source Info: 5/30/2008, Vol. 57 Issue RR-4, p1; Subject Term: WHOOPING cough; Subject Term: PREVENTION; Subject Term: TETANUS; Subject Term: DIPHTHERIA; Subject Term: PREGNANT women; Subject Term: PUERPERIUM; Subject Term: INFANTS; Number of Pages: 50p; Illustrations: 12 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiao, Shi
AU - Liu, Bingci
AU - Gao, Ai
AU - Ye, Meng
AU - Jia, Xiaowei
AU - Zhang, Fengmei
AU - Liu, Haifeng
AU - Shi, Xianglin
AU - Huang, Chuanshu
T1 - Benzo(a)pyrene-caused increased G1–S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2008/05/30/
VL - 178
IS - 3
M3 - Article
SP - 167
EP - 175
SN - 03784274
AB - Abstract: Benzo(a)pyrene (B(a)P) is a potent lung carcinogen mainly derived from tobacco smoking and environmental contamination, however, the molecular mechanisms by which it accelerates the cell cycle progression and induces the abnormal cell proliferation are still far away from understood. Our current analysis of human embryo lung fibroblasts (HELF) showed that B(a)P exposure was able to promote cell cycle G1–S phase transition. This effect was correlated with c-Jun activation because inhibition of c-Jun by its dominant negative mutant (TAM67) reversed B(a)P action on cell cycle with the down-regulation of expression of cyclin D1, pRb and E2F1. Further study found that overexpression of dominant negative mutants of, PI-3K or Akt, dramatically reduced B(a)P-induced the activation of c-Jun and extracellular signaling regulated kinase (ERK), but not c-Jun NH2 terminal kinase (JNK). Inhibition of p53 by either its inhibitor pifithrin-α or p53 siRNA markedly increased B(a)P-induced the activation of c-Jun, Akt and ERK in this context. Take together, our results indicate that c-Jun activation by p53-dependent PI-3K/Akt/ERK pathway is responsible for B(a)P-induced cell cycle alternations in human embryo lung fibroblasts. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Benzopyrene
KW - Human embryos
KW - Lungs
KW - Fibroblasts
KW - Akt
KW - B(a)P
KW - Benzo(a)pyrene ( B(a)P )
KW - c-Jun
KW - Cell cycle
KW - dimethyl sulfoxide ( DMSO )
KW - human embryo lung fibroblast ( HELF )
KW - human embryo lung fibroblast cotransfected with AP-1 luciferase reporter plasmid and dominant negative mutant plasmid of Akt ( HELF-AP-1-DN-Akt )
KW - human embryo lung fibroblast stably cotransfected with AP-1 luciferase reporter plasmid and dominant negative mutant plasmid of PI-3K (Δp85) ( HELF-AP-1-DN-Δp85 )
KW - human embryo lung fibroblast stably cotransfected with cyclin D1 luciferase reporter plasmid and dominant negative mutant plasmid of c-Jun (TAM67) ( HELF-cyclin D1-TAM67 )
KW - human embryo lung fibroblast stably transfected with cyclin D1 luciferase reporter plasmid ( HELF-cyclin D1/vector )
KW - human embryo lung fibroblast stably transfected with p53 siRNA ( HELF-sip53 cells )
KW - human embryo lung fibroblast transfected with AP-1 luciferase reporter plasmid ( HELF-AP-1/vector )
KW - p53
KW - phosphorylation of Akt ( p-Akt )
KW - phosphorylation of c-Jun ( p-c-Jun )
KW - phosphorylation of ERK ( p-ERK )
KW - phosphorylation of JNK ( p-JNK )
KW - phosphorylation of retinoblastoma protein ( pRb )
KW - Signaling pathway
N1 - Accession Number: 32051267; Jiao, Shi 1; Liu, Bingci 1; Email Address: bcliu@263.net; Gao, Ai 1; Ye, Meng 1; Jia, Xiaowei 1; Zhang, Fengmei 1; Liu, Haifeng 1; Shi, Xianglin 2; Huang, Chuanshu 3; Affiliations: 1: Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, 29 Nan Wei Road, Beijing 100050, PR China; 2: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; 3: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA; Issue Info: May2008, Vol. 178 Issue 3, p167; Thesaurus Term: Benzopyrene; Subject Term: Human embryos; Subject Term: Lungs; Subject Term: Fibroblasts; Author-Supplied Keyword: Akt; Author-Supplied Keyword: B(a)P; Author-Supplied Keyword: Benzo(a)pyrene ( B(a)P ); Author-Supplied Keyword: c-Jun; Author-Supplied Keyword: Cell cycle; Author-Supplied Keyword: dimethyl sulfoxide ( DMSO ); Author-Supplied Keyword: human embryo lung fibroblast ( HELF ); Author-Supplied Keyword: human embryo lung fibroblast cotransfected with AP-1 luciferase reporter plasmid and dominant negative mutant plasmid of Akt ( HELF-AP-1-DN-Akt ); Author-Supplied Keyword: human embryo lung fibroblast stably cotransfected with AP-1 luciferase reporter plasmid and dominant negative mutant plasmid of PI-3K (Δp85) ( HELF-AP-1-DN-Δp85 ); Author-Supplied Keyword: human embryo lung fibroblast stably cotransfected with cyclin D1 luciferase reporter plasmid and dominant negative mutant plasmid of c-Jun (TAM67) ( HELF-cyclin D1-TAM67 ); Author-Supplied Keyword: human embryo lung fibroblast stably transfected with cyclin D1 luciferase reporter plasmid ( HELF-cyclin D1/vector ); Author-Supplied Keyword: human embryo lung fibroblast stably transfected with p53 siRNA ( HELF-sip53 cells ); Author-Supplied Keyword: human embryo lung fibroblast transfected with AP-1 luciferase reporter plasmid ( HELF-AP-1/vector ); Author-Supplied Keyword: p53; Author-Supplied Keyword: phosphorylation of Akt ( p-Akt ); Author-Supplied Keyword: phosphorylation of c-Jun ( p-c-Jun ); Author-Supplied Keyword: phosphorylation of ERK ( p-ERK ); Author-Supplied Keyword: phosphorylation of JNK ( p-JNK ); Author-Supplied Keyword: phosphorylation of retinoblastoma protein ( pRb ); Author-Supplied Keyword: Signaling pathway; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.toxlet.2008.03.012
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Petibone, D.M.
AU - Morris, S.M.
AU - Hotchkiss, C.E.
AU - Mattison, D.R.
AU - Tucker, J.D.
T1 - Technique for culturing Macaca mulatta peripheral blood lymphocytes for fluorescence in situ hybridization of whole chromosome paints
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2008/05/31/
VL - 653
IS - 1/2
M3 - Article
SP - 76
EP - 81
SN - 13835718
AB - Abstract: The rhesus monkey (Macaca mulatta) has long been an important model in biomedical and behavioral research. The biomedical importance of M. mulatta is due to its 93% genetic similarity with humans and its complex social behavior. The recent sequencing of the M. mulatta genome has enhanced its role in biological research. However, the use of the macaque as an experimental model in cytogenetic assays has been problematic due to difficulties in obtaining large numbers of well-spread cells in metaphase without the use of extremely toxic mitogens such as staphylococcal enterotoxin A (SEA). Here we describe a technique for culturing and producing sufficient numbers of cells in metaphase using the common mitogens phytohemagglutinin (PHA), concanavalin A (ConA), and T-cell growth factor (TCGF) which act synergistically to induce M. mulatta T-lymphocyte division. Using this method we have obtained a mitotic index in 48h cultures of 12.0±2.2 metaphase cells/100cells (n =5 animals). Fluorescence in situ hybridization with whole chromosome painting of M. mulatta cells was performed with human whole-chromosome probes that labeled the following chromosomes for human (M. mulatta): 1(1), 2q(12), 2p(13), 4(5) pairs in red, and 3(2), 5(6) and 6(4) pairs in green. In humans this probe combination simultaneously paints 3 chromosome pairs in red and 3 in green, whereas in M. mulatta 4 chromosome pairs are labeled in red and 3 pairs are labeled in green. Using this method we show a baseline frequency of 0.026 translocations per 100 whole-genome cell equivalents in peripheral blood lymphocytes obtained from unexposed adolescent non-human primates. This method will add to the usefulness of M. mulatta as an animal model in biomedical research. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemical ecology
KW - Organic compounds
KW - Genetic regulation
KW - Polymerase chain reaction
KW - Baseline
KW - Chromosome translocations
KW - Macaca mulatta
KW - Methods
KW - Whole chromosome painting
N1 - Accession Number: 32646434; Petibone, D.M. 1; Morris, S.M. 2; Hotchkiss, C.E. 3; Mattison, D.R. 4; Tucker, J.D. 1; Email Address: jtucker@biology.biosci.wayne.edu; Affiliations: 1: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, United States; 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, United States; 3: The Bionetics Corporation, 3900 NCTR Road, Jefferson, AR 72079, United States; 4: National Institutes of Health, HHS, 6100 Executive Boulevard, RM 4A01 MSC 7510, Bethesda, MD 20892-7510, United States; Issue Info: May2008, Vol. 653 Issue 1/2, p76; Thesaurus Term: Chemical ecology; Thesaurus Term: Organic compounds; Subject Term: Genetic regulation; Subject Term: Polymerase chain reaction; Author-Supplied Keyword: Baseline; Author-Supplied Keyword: Chromosome translocations; Author-Supplied Keyword: Macaca mulatta; Author-Supplied Keyword: Methods; Author-Supplied Keyword: Whole chromosome painting; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.mrgentox.2008.03.012
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McIntyre, Jack
AU - Cheal, Karen
AU - Bartels, Steve
AU - Durai, U. N.
AU - Herr, Betsy McDonel
AU - Quijano, Louise
AU - Llorente, Maria
AU - Ware, James H.
AU - Costantino, Giuseppe
AU - Miller, Chris
AU - Kirchner, Joanne
AU - Levkoff, Sue E.
T1 - Anxiety and Depressive Disorders in Older Primary Care Patients: Defining a Clinical Severity Gradient Corresponding to Differences in Health Status, Functioning, and Health Service Use.
JO - Ageing International
JF - Ageing International
Y1 - 2008/06//
VL - 32
IS - 2
M3 - Article
SP - 93
EP - 107
PB - Springer Science & Business Media B.V.
SN - 01635158
AB - Anxiety and depression are common psychiatric disorders affecting older persons. To explore the relationships between these disorders and client characteristics, we examined data from the baseline phase of PRISM-E, a multisite randomized trial comparing two models of service delivery for older persons aged 65 and over identified in primary care settings with depression, anxiety, and/or at-risk drinking. Clinical characteristics, functioning and service use were compared across five diagnostic groups of study participants ( n = 1,763; mean age = 73.8 ± 6.3 years, 71% male) with (1) anxiety only ( n = 82), (2) minor/other depression ( n = 502), (3) major depression ( n = 700), (4) mixed minor/other depression and anxiety ( n = 121), and (5) mixed major depression and anxiety ( n = 358). Increasing functional problems and use of services were found across the five diagnostic subgroups, corresponding to a gradient of increasing severity for health status, number of medical disorders, SF-36 mental component score, suicidal or death ideation, and number of hospital stays, emergency room visits, and outpatient medical visits. Multivariate analyses controlling for site, demographic variables, and clinical characteristics confirmed the observed clinical severity gradient. Anxiety alone and anxiety comorbid with depression represent the two extremes of the severity gradient from the least to the most complicated and severe clinical presentations. Primary care clinicians identifying anxiety disorders in older persons should also screen for depression due to the relative infrequency of anxiety disorder alone and the significant clinical implications of co-occurring anxiety and depression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Ageing International is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL depression
KW - GEROPSYCHOLOGY
KW - AGING -- Psychological aspects
KW - OLDER people -- Mental health
KW - MENTAL health services
KW - UNITED States
KW - Anxiety
KW - Depression
KW - Older persons
N1 - Accession Number: 42637954; McIntyre, Jack 1; Email Address: jmcintyre@unityhealth.org Cheal, Karen 2 Bartels, Steve 3 Durai, U. N. 4 Herr, Betsy McDonel 5 Quijano, Louise 6 Llorente, Maria 7 Ware, James H. 8 Costantino, Giuseppe 9 Miller, Chris 2 Kirchner, Joanne 2,10 Levkoff, Sue E.; Affiliation: 1: Department of Psychiatry and Behavioral Health, Unity Health System, 2000 Winton Road South, Suite 4-303, Rochester, NY, USA 2: Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA 3: New Hampshire Dartmouth Psychiatric Research Center, Lebanon, NH, USA 4: Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA 5: Center for Mental Health Services, U.S. Substance Abuse and Mental Health Services Administration, Rockville, MD, USA 6: Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USA 7: Miami Veterans Affairs Medical Center, Miami, FL, USA 8: Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA 9: Lutheran Sunset Park Family Health Center Network, Brooklyn, NY, USA 10: Department of Veterans Affairs South Central Mental Illness Research and Clinical Center, North Little Rock, AK, USA; Source Info: Jun2008, Vol. 32 Issue 2, p93; Subject Term: MENTAL depression; Subject Term: GEROPSYCHOLOGY; Subject Term: AGING -- Psychological aspects; Subject Term: OLDER people -- Mental health; Subject Term: MENTAL health services; Subject Term: UNITED States; Author-Supplied Keyword: Anxiety; Author-Supplied Keyword: Depression; Author-Supplied Keyword: Older persons; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 15p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1007/s12126-008-9011-6
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Domino, M. E.
AU - Maxwell, J.
AU - Cody, M.
AU - Cheal, K.
AU - Busch, A. B.
AU - Van Stone, W. W.
AU - Cooley, S. G.
AU - Zubtritsky, C.
AU - Estes, C. L.
AU - Shen, Y.
AU - Lynch, M.
AU - Grantham, S.
AU - Wohlford, P.
AU - Aoyama, M. C.
AU - Fitzpatrick, J.
AU - Zaman, S.
AU - Dodson, J.
AU - Levkoff, S. E.
T1 - The Influence of Integration on the Expenditures and Costs of Mental Health and Substance Use Care: Results from the Randomized PRISM-E Study.
JO - Ageing International
JF - Ageing International
Y1 - 2008/06//
VL - 32
IS - 2
M3 - Article
SP - 108
EP - 127
PB - Springer Science & Business Media B.V.
SN - 01635158
AB - We compared the healthcare costs associated with an integrated care model to an enhanced referral model for the treatment of depression, anxiety, and at-risk drinking from the randomized Primary Care Research in Substance Abuse and Mental Health for the Elderly study. We examined total healthcare costs and cost components, separately for Veterans Affairs (VA) and non-VA participants. No differences in total health expenditures were detected between study arms. No differences in behavioral health expenditures were detected for non-VA sites, but the VA integrated arm had slightly higher ($38; p < 0.05) behavioral health costs. Differences in other types of services use were detected. [ABSTRACT FROM AUTHOR]
AB - Copyright of Ageing International is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care costs
KW - MENTAL health
KW - SUBSTANCE abuse
KW - MEDICAL care for the aged
KW - MENTAL depression -- Treatment
KW - ANXIETY -- Treatment
KW - Anxiety
KW - Cost
KW - Depression
KW - Elderly
KW - Integrated care
N1 - Accession Number: 42637953; Domino, M. E. 1; Email Address: domino@unc.edu Maxwell, J. 2 Cody, M. 3 Cheal, K. 4 Busch, A. B. 5; Email Address: abusch@hcp.med.harvard.edu Van Stone, W. W. 6 Cooley, S. G. 7 Zubtritsky, C. 8 Estes, C. L. 9 Shen, Y. 10 Lynch, M. 11 Grantham, S. 2 Wohlford, P. 12 Aoyama, M. C. 13 Fitzpatrick, J. 14 Zaman, S. 2 Dodson, J. 15 Levkoff, S. E. 16; Affiliation: 1: The University of North Carolina School of Public Health, 1104G McGavran-Greenberg Hall, CB#7411, Chapel Hill, NC 27599-7411, USA 2: JSI Research and Training Institute, Inc., 44 Farnsworth Street, Boston, MA 02210, USA 3: VA Office of Research & Development, Department of Veterans Affairs, 810 Vermont Ave., NW (12), Washington, DC 20420, USA 4: Brigham and Women's Hospital, 1249 Boylston Street, 3rd Floor, Boston, MA 02215, USA 5: Departments of Psychiatry and Health Care Policy, Harvard Medical School, McLean Hospital, Alcohol and Drug Abuse Treatment Program, Proctor 305, 115 Mill St., Belmont, MA 02478, USA 6: Office of Mental Health Services, Department of Veterans Affairs, 810 Vermont Ave., NW (116A), Washington, DC 20420, USA 7: Office of Geriatrics and Extended Care, Department of Veterans Affairs, 810 Vermont Ave., NW, Washington, DC 20420, USA 8: Managed Care Initiatives, University of Pennyslvania, 3600 Market Street, 7th Floor, Philadelphia, PA 19104, USA 9: Institute for Health and Aging, University of California, San Francisco, 3333 California St., Suite 340, San Francisco, CA 94118, USA 10: Center for Healthcare Knowledge Management, VA East Orange Medical Center, VA New Jersey Healthcare System, 385 Tremont Avenue, 129, East Orange, NJ 07018, USA 11: LifeLong Medical Care, P.O. Box 11247, Berkeley, CA 94712-2247, USA 12: Division of State and Community System Development, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Department of Health andHuman Services, 5600 Fishers Lane, Room 15C-18, Rockville, MD 20857, USA 13: Indian Health Service, Office of Clinical & Preventive Service, Division of Nursing, Health Resources Services Administration, 801 East Thompson Ave., Rockville, MD 20852, USA 14: Department of Psychiatry and Behavioral Health Services, Lutheran HealthCare, 15055th St., Brooklyn, NY 11220, USA 15: Department of Medicine, Columbia University Medical Center, 622 W. 168th Street, VC-205, New York, NY 10032, USA 16: Brigham and Women's Hospital and Harvard Medical School, 1249 Boyston Street, 3rd Floor, Boston, MA 02210, USA; Source Info: Jun2008, Vol. 32 Issue 2, p108; Subject Term: MEDICAL care costs; Subject Term: MENTAL health; Subject Term: SUBSTANCE abuse; Subject Term: MEDICAL care for the aged; Subject Term: MENTAL depression -- Treatment; Subject Term: ANXIETY -- Treatment; Author-Supplied Keyword: Anxiety; Author-Supplied Keyword: Cost; Author-Supplied Keyword: Depression; Author-Supplied Keyword: Elderly; Author-Supplied Keyword: Integrated care; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 20p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1007/s12126-008-9010-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meleg, Edina
AU - Bányai, Krisztián
AU - Martella, Vito
AU - Jiang, Baoming
AU - Kocsis, Béla
AU - Kisfali, Péter
AU - Melegh, Béla
AU - Szücsl, György
T1 - Detection and Quantification of Group C Rotaviruses in Communal Sewage.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/06//
VL - 74
IS - 11
M3 - Article
SP - 3394
EP - 3399
SN - 00992240
AB - Group C rotaviruses have been recognized as a cause of acute gastroenteritis in humans, cattle, and swine, although the true epidemiologic and clinical importance of this virus in these hosts has not yet been fully established. A real-time PCR assay based on a broadly reactive primer pair was developed and used to quantitatively determine the viral load of group C rotaviruses in environmental samples. A total of 35 raw and 35 treated sewage samples collected at the same sampling time in four Hungarian sewage treatment plants during a survey in 2005 were tested for the presence of group C rotaviruses. The overall detection rates were 91% (32 of 35) for the influent and 57% (20 of 35) for the effluent samples. Molecular characterization of the amplified partial VP6 gene revealed the cocirculation of human and animal (i.e., bovine and porcine) strains that were easily distinguishable by melting curve analysis. Human strains yielded relatively high viral loads (mean, 1.2 × 107; median, 6.9 × 105 genome equivalents per liter influent sewage) and appeared to display seasonal activity over the study period, whereas animal strains appeared to circulate throughout the year at much lower average titers (bovine strains mean, 9.9 × 104; median, 3.0 × 104; porcine strains mean, 3.9 × 104; median, 3.1 × 104 genome equivalents per liter influent sewage). Our findings suggest that monitoring of communal sewage may provide a good surrogate for investigating the epidemiology and ecology of group C rotaviruses in humans and animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEWAGE disposal plants
KW - SEWAGE -- Purification
KW - ROTAVIRUSES
KW - REOVIRUSES
KW - GASTROENTERITIS
KW - ALIMENTARY canal -- Inflammation
KW - COMMUNICABLE diseases -- Transmission
N1 - Accession Number: 32686296; Meleg, Edina 1,2 Bányai, Krisztián 1,2 Martella, Vito 3 Jiang, Baoming 4 Kocsis, Béla 2 Kisfali, Péter 5 Melegh, Béla 5 Szücsl, György 1,2; Email Address: szucsgy@baranya.antsz.hu; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary 2: Department of Medical Microbiology and Immunology, Hungary 3: Department of Animal Health and Well-Being, University of Bari, Sp Casamassima Km 3, 70010 Valenzano, Bari, Italy 4: Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, Georgia 30333 5: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary; Source Info: Jun2008, Vol. 74 Issue 11, p3394; Subject Term: SEWAGE disposal plants; Subject Term: SEWAGE -- Purification; Subject Term: ROTAVIRUSES; Subject Term: REOVIRUSES; Subject Term: GASTROENTERITIS; Subject Term: ALIMENTARY canal -- Inflammation; Subject Term: COMMUNICABLE diseases -- Transmission; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; NAICS/Industry Codes: 562212 Solid Waste Landfill; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; NAICS/Industry Codes: 562210 Waste treatment and disposal; Number of Pages: 6p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.02895-07
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nakata, Akinori
AU - Takahashi, Masaya
AU - Ikeda, Tomoko
AU - Hojou, Minoru
AU - Araki, Shunichi
T1 - Perceived psychosocial job stress and sleep bruxism among male and female workers.
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
Y1 - 2008/06//
VL - 36
IS - 3
M3 - Article
SP - 201
EP - 209
SN - 03015661
AB - Objective: Psychosocial job stress has been associated with sleep disturbances, but its association with sleep bruxism (SB), the stereotype movement disorder related to sleep, is not well understood. The aim of this epidemiological study was to examine the relationship between psychosocial job stress and SB. Methods: 1944 male and 736 female factory workers participated in this study (response rate 78.1%). Perceived job stress was evaluated with the Japanese version of the generic job stress questionnaire, which covered 13 job stress variables. SB was assessed by the question, ‘Do you grind or clench your teeth during your sleep or has anyone in your family told you that you grind your teeth during your sleep?’ Response options were ‘never’, ‘seldom’, ‘sometimes’ or ‘often’. SB was considered present if the answer was ‘sometimes’ or ‘often’. Results: Overall, 30.9% of males and 20.2% of females reported SB. In males, workers with low social support from supervisors [odds ratio (OR) = 1.34, 95% confidence interval (CI) 1.08–1.68] or from colleagues (OR 1.47, 95% CI 1.17–1.83), and high depressive symptoms (OR 1.60, 95% CI 1.26–2.03) had a significantly increased risk of SB after controlling for confounders. By contrast, no significant association was found in females. Conclusions: We conclude that SB is weakly associated with some aspects of job stress in men but not in women among the Japanese working population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Dentistry & Oral Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRUXISM
KW - ORAL habits
KW - TEETH abnormalities
KW - TEETH -- Abrasion
KW - JOB stress
KW - epidemiology
KW - job stress
KW - parasomniao
KW - psychosocial aspects of oral health
KW - sleep bruxism
N1 - Accession Number: 31939562; Nakata, Akinori 1; Email Address: nakataa-tky@umin.ac.jp Takahashi, Masaya 1 Ikeda, Tomoko 2 Hojou, Minoru 3 Araki, Shunichi 1; Affiliation: 1: National Institute of Occupational Safety and Health, Kawasaki, Japan. 2: Department of Nursing, School of Health Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan. 3: Ota Regional Occupational Health Center, Tokyo, Japan.; Source Info: Jun2008, Vol. 36 Issue 3, p201; Subject Term: BRUXISM; Subject Term: ORAL habits; Subject Term: TEETH abnormalities; Subject Term: TEETH -- Abrasion; Subject Term: JOB stress; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: job stress; Author-Supplied Keyword: parasomniao; Author-Supplied Keyword: psychosocial aspects of oral health; Author-Supplied Keyword: sleep bruxism; Number of Pages: 9p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1111/j.1600-0528.2007.00388.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105674008
T1 - Perceived psychosocial job stress and sleep bruxism among male and female workers.
AU - Nakata A
AU - Takahashi M
AU - Ikeda T
AU - Hojou M
AU - Araki S
Y1 - 2008/06//
N1 - Accession Number: 105674008. Language: English. Entry Date: 20081024. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed; Public Health. Special Interest: Dental Care; Public Health. NLM UID: 0410263.
KW - Bruxism -- Etiology
KW - Occupational Diseases -- Complications
KW - Stress, Psychological -- Complications
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Bruxism -- Psychosocial Factors
KW - Depression -- Complications
KW - Female
KW - Japan
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Psychosocial Factors
KW - Psychometrics
KW - Questionnaires
KW - Self Assessment
KW - Sex Factors
KW - Stress, Psychological -- Psychosocial Factors
KW - Support, Psychosocial
KW - Human
SP - 201
EP - 209
JO - Community Dentistry & Oral Epidemiology
JF - Community Dentistry & Oral Epidemiology
JA - COMMUNITY DENT ORAL EPIDEMIOL
VL - 36
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVE: Psychosocial job stress has been associated with sleep disturbances, but its association with sleep bruxism (SB), the stereotype movement disorder related to sleep, is not well understood. The aim of this epidemiological study was to examine the relationship between psychosocial job stress and SB. METHODS: 1944 male and 736 female factory workers participated in this study (response rate 78.1%). Perceived job stress was evaluated with the Japanese version of the generic job stress questionnaire, which covered 13 job stress variables. SB was assessed by the question, 'Do you grind or clench your teeth during your sleep or has anyone in your family told you that you grind your teeth during your sleep?' Response options were 'never', 'seldom', 'sometimes' or 'often'. SB was considered present if the answer was 'sometimes' or 'often'. RESULTS: Overall, 30.9% of males and 20.2% of females reported SB. In males, workers with low social support from supervisors [odds ratio (OR) = 1.34, 95% confidence interval (CI) 1.08-1.68] or from colleagues (OR 1.47, 95% CI 1.17-1.83), and high depressive symptoms (OR 1.60, 95% CI 1.26-2.03) had a significantly increased risk of SB after controlling for confounders. By contrast, no significant association was found in females. CONCLUSIONS: We conclude that SB is weakly associated with some aspects of job stress in men but not in women among the Japanese working population.
SN - 0301-5661
AD - Division of Applied Research and Technology, National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. nakataa-tky@umin.ac.jp
U2 - PMID: 18474052.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wonnacott, K.
AU - Lavoie, D.
AU - Fiorentino, R.
AU - McIntyre, M.
AU - Huang, Y.
AU - Hirschfeld, S.
T1 - Investigational new drugs submitted to the Food and Drug Administration that are placed on clinical hold: the experience of the Office of Cellular, Tissue and Gene Therapy.
JO - Cytotherapy (Taylor & Francis Ltd)
JF - Cytotherapy (Taylor & Francis Ltd)
Y1 - 2008/06//
VL - 10
IS - 3
M3 - Article
SP - 312
EP - 316
PB - Taylor & Francis Ltd
SN - 14653249
AB - Background Cell and gene therapies are medical products regulated by the U.S. Food and Drug Administration (FDA) within its Center of Biologics Evaluation and Research (CBER) in the Office of Cellular, Tissue, and Gene Therapy (OCTGT). Clinical research using cell and gene therapies in the United States must be conducted under an Investigational New Drug (IND) application. After an initial, 30-day review FDA either places an IND on clinical hold or allows the IND to proceed. Methods We reviewed letters sent by OCTGT to IND sponsors that were placed on clinical hold. We categorized each deficiency and determined its frequency. Results We found that similar deficiencies existed across IND applications and we tabulated the most common deficiencies. Discussion We discussed the deficiencies and the resources that can help individuals avoid those deficiencies. We believe that awareness of the common deficiencies along with the applicable resources can reduce the frequency of clinical holds and allow clinical studies to proceed without delay. We also believe that this information will guide the FDA as to how to facilitate development of safe and effective cell and gene therapies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cytotherapy (Taylor & Francis Ltd) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELLULAR therapy
KW - GENE therapy
KW - DEFICIENCY diseases
KW - UNITED States
KW - cell therapy
KW - chemistry
KW - clinical
KW - Food and Drug Administration (FDA)
KW - gene therapy
KW - hold
KW - investigational new drugs (IND)
KW - manufacturing and controls (CMC)
KW - Office of Cellular
KW - pre-clinical
KW - Tissue and Gene Therapy (OCTGT)
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 31674770; Wonnacott, K. 1; Email Address: keith.wonnacott@fda.hhs.gov Lavoie, D. 2 Fiorentino, R. 3 McIntyre, M. 4 Huang, Y. 1 Hirschfeld, S. 5; Affiliation: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA 2: Regulatory Affairs Programs, GE Healthcare, Waukesha, Wisconsin, USA 3: Center for Devices and Radiological Health, Rockville, Maryland, USA 4: Biologics Consulting Group Inc., Rockville, Maryland, USA 5: National Institute of Child Health and Human Development, Bethesda, Maryland, USA; Source Info: Jun2008, Vol. 10 Issue 3, p312; Subject Term: CELLULAR therapy; Subject Term: GENE therapy; Subject Term: DEFICIENCY diseases; Subject Term: UNITED States; Author-Supplied Keyword: cell therapy; Author-Supplied Keyword: chemistry; Author-Supplied Keyword: clinical; Author-Supplied Keyword: Food and Drug Administration (FDA); Author-Supplied Keyword: gene therapy; Author-Supplied Keyword: hold; Author-Supplied Keyword: investigational new drugs (IND); Author-Supplied Keyword: manufacturing and controls (CMC); Author-Supplied Keyword: Office of Cellular; Author-Supplied Keyword: pre-clinical; Author-Supplied Keyword: Tissue and Gene Therapy (OCTGT); Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/14653240801910905
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woo, Emily Jane
AU - Ball, Robert
AU - Burwen, Dale R.
AU - Braun, M. Miles
T1 - Effects of Stratification on Data Mining in the US Vaccine Adverse Event Reporting System (VAERS).
JO - Drug Safety
JF - Drug Safety
Y1 - 2008/06//
VL - 31
IS - 8
M3 - Article
SP - 667
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - BACKGROUND: Vaccines are administered differentially according to age and sex, and disease patterns also vary among people of different age and sex groups. Estimates of disproportionality should be calculated based on comparisons of groups that have a similar likelihood of receiving similar vaccines and experiencing similar adverse events, to prevent false disproportionality from occurring. Stratified empirical Bayesian (EB) methods have been compared with crude, but not stratified, proportional reporting ratios (PRRs) in their performance on adverse event data. OBJECTIVES: (i) to implement stratification of PRR; (ii) to quantify and compare vaccine-event pairs that are highlighted by PRR and EB05 (the lower bound of the 90% CI of the EB geometric mean), for both crude and stratified; and (iii) to evaluate the effects of stratification by age and sex, in identifying adverse events that are accepted to be caused by vaccines. METHODS: We applied EB and PRR data mining methods to data from the US Vaccine Adverse Event Reporting System (VAERS). We stratified PRR and EB05 by age and sex. To study the effects of stratification, we compared the crude PRR and stratified PRR. We also assessed the crude EB05 and stratified EB05, and then compared the effects of stratification on EB05 and PRR. RESULTS: Stratification not only changed the number of vaccine-event pairs that were highlighted, but also changed which pairs were highlighted. There were 283 vaccine-event pairs that were highlighted by the crude EB05, but not the stratified; 12 that were highlighted by the stratified EB05, but not the crude; and 162 that were highlighted by both. Similarly, there were 701 vaccine-event pairs that were highlighted by the crude PRR, but not the stratified; 139 that were highlighted by the stratified PRR, but not the crude; and 895 that were highlighted by both. There were 1466 vaccine-event pairs in which the effect of stratification was different for EB05 and PRR. CONCLUSION: To our knowledge, this is the first published analysis using stratified PRRs. In this analysis of passive surveillance data, stratification revealed and reduced confounding in EB and PRR, and also unmasked some vaccine-event pairs that the crude values did not highlight. Stratification should be applied if confounding is suspected. By decreasing the total number of highlighted vaccine-event pairs, stratification is likely to increase efficiency and therefore might reduce workload. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - BAYESIAN analysis
KW - DISEASES
KW - HUMAN sexuality
KW - AGE
KW - COMMUNICABLE diseases
N1 - Accession Number: 33410310; Woo, Emily Jane 1; Email Address: jane.woo@fda.hhs.gov Ball, Robert 1 Burwen, Dale R. 1 Braun, M. Miles 1; Affiliation: 1: US Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA; Source Info: 2008, Vol. 31 Issue 8, p667; Subject Term: VACCINES; Subject Term: BAYESIAN analysis; Subject Term: DISEASES; Subject Term: HUMAN sexuality; Subject Term: AGE; Subject Term: COMMUNICABLE diseases; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105549737
T1 - Effects of Stratification on Data Mining in the US Vaccine Adverse Event Reporting System (VAERS)
AU - Woo EJ
AU - Ball R
AU - Burwen DR
AU - Braun MM
Y1 - 2008/06//
N1 - Accession Number: 105549737. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Australia & New Zealand; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. NLM UID: 9002928.
KW - Adverse Drug Event
KW - Resource Databases
KW - Vaccines -- Adverse Effects
KW - Age Factors
KW - Models, Statistical
KW - Probability
KW - Sex Factors
KW - United States Food and Drug Administration
KW - United States
KW - Human
SP - 667
EP - 674
JO - Drug Safety
JF - Drug Safety
JA - DRUG SAF
VL - 31
IS - 8
PB - Springer Science & Business Media B.V.
SN - 0114-5916
AD - US Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA.
U2 - PMID: 18636785.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - McCann, Catherine M.
AU - Vyse, Andrew J.
AU - Salmon, Roland L.
AU - Thomas, Daniel
AU - Williams, Diana J. L.
AU - McGarry, John W.
AU - Pebody, Richard
AU - Trees, Alexander J.
T1 - Lack of Serologic Evidence of Neospora caninum in Humans, England.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/06//
VL - 14
IS - 6
M3 - Article
SP - 978
EP - 980
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Retrospective testing of 3,232 serum samples from the general population and 518 serum samples from a high-risk group showed no evidence of human exposure to Neospora caninum in England. Results were obtained by using immunofluorescence antibody testing and ELISA to analyze frequency distribution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Coccidia
KW - Parasitic diseases
KW - Protozoan diseases -- Diagnosis
KW - Parasites
KW - Immunofluorescence
KW - Fluorescent antibody technique
KW - Enzyme-linked immunosorbent assay
KW - Great Britain
N1 - Accession Number: 32440727; McCann, Catherine M. 1; Vyse, Andrew J. 2; Salmon, Roland L. 3; Thomas, Daniel 3; Williams, Diana J. L. 1; McGarry, John W. 1; Pebody, Richard; Trees, Alexander J. 1; Email Address: trees@liverpool.ac.uk; Affiliations: 1: University of Liverpool, Liverpool, UK; 2: Health Protection Agency, London, UK; 3: National Public Health Service for Wales, Cardiff, Wales, UK; Issue Info: Jun2008, Vol. 14 Issue 6, p978; Thesaurus Term: RESEARCH; Thesaurus Term: Coccidia; Subject Term: Parasitic diseases; Subject Term: Protozoan diseases -- Diagnosis; Subject Term: Parasites; Subject Term: Immunofluorescence; Subject Term: Fluorescent antibody technique; Subject Term: Enzyme-linked immunosorbent assay; Subject: Great Britain; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - Erratum to “Mathematical treatment of plates with colony counts outside the acceptable range”: [Food Microbiology 25 (2008) 92–98]
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2008/06//
VL - 25
IS - 4
M3 - Correction notice
SP - 633
EP - 633
SN - 07400020
N1 - Accession Number: 31896237; Blodgett, Robert J. 1; Email Address: robert.blodgett@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, Room 2D-011, HFS-012, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Jun2008, Vol. 25 Issue 4, p633; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.fm.2007.07.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Barrett, Harrison H.
AU - Furenlid, Lars R.
AU - Freed, Melanie
AU - Hesterman, Jacob Y.
AU - Kupinski, Matthew A.
AU - Clarkson, Eric
AU - Whitaker, Meredith K.
T1 - Adaptive SPECT.
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
Y1 - 2008/06//
VL - 27
IS - 6
M3 - Article
SP - 775
EP - 788
SN - 02780062
AB - Adaptive imaging systems alter their data-acquisition configuration or protocol in response to the image information received. An adaptive pinhole single-photon emission computed tomography (SPECT) system might acquire an initial scout image to obtain preliminary information about the radiotracer distribution and then adjust the configuration or sizes of the pinholes, the magnifications, or the projection angles in order to improve performance. This paper briefly describes two small-animal SPECT systems that allow this flexibility and then presents a framework for evaluating adaptive systems in general, and adaptive SPECT systems in particular. The evaluation is in terms of the performance of linear observers on detection or estimation tasks. Expressions are derived for the ideal linear (Hotelling) observer and the ideal linear (Wiener) estimator with adaptive imaging. Detailed expressions for the performance figures of merit are given, and possible adaptation rules are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SINGLE-photon emission computed tomography
KW - IMAGING systems
KW - RADIOGRAPHIC magnification
KW - RADIOACTIVE tracers
KW - ANGLES (Geometry)
KW - DATA
KW - PROJECTION
KW - PERFORMANCE
KW - IMAGE analysis
KW - Adaptive imaging
KW - Hotelling observer
KW - image quality
KW - single-photon emission computed tomography (SPECT)
KW - Wiener estimator
N1 - Accession Number: 32741415; Barrett, Harrison H. 1; Email Address: barrett@radiology.arizona.edu Furenlid, Lars R. 1 Freed, Melanie 2 Hesterman, Jacob Y. 3 Kupinski, Matthew A. 1 Clarkson, Eric 1 Whitaker, Meredith K. 1; Affiliation: 1: Center for Gamma-Ray Imaging and the Department of Radiology, University of Arizona, Tucson, AZ 85724 USA and also with the College of Optical Sciences, University of Arizona, Tucson. AZ 85721 USA 2: Food and Drug Administration, Silver Spring, MD 20993 USA 3: Bioscan. Inc., Washington. DC 20007 USA; Source Info: Jun2008, Vol. 27 Issue 6, p775; Subject Term: SINGLE-photon emission computed tomography; Subject Term: IMAGING systems; Subject Term: RADIOGRAPHIC magnification; Subject Term: RADIOACTIVE tracers; Subject Term: ANGLES (Geometry); Subject Term: DATA; Subject Term: PROJECTION; Subject Term: PERFORMANCE; Subject Term: IMAGE analysis; Author-Supplied Keyword: Adaptive imaging; Author-Supplied Keyword: Hotelling observer; Author-Supplied Keyword: image quality; Author-Supplied Keyword: single-photon emission computed tomography (SPECT); Author-Supplied Keyword: Wiener estimator; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.11091TMI.2007.91324I
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Laugier, Pascal
AU - Wear, Keith A.
AU - Waters, Kendall R.
T1 - Introduction to the Special Issue on Diagnostic and Therapeutic Applications of Ultrasound in Bone-Part I.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2008/06//
VL - 55
IS - 6
M3 - Article
SP - 1177
EP - 1178
SN - 08853010
AB - The article discusses various reports published within the issue, including the article on numerical modeling and another on guided waves.
KW - NUMERICAL analysis
KW - WAVES (Physics)
N1 - Accession Number: 32697903; Laugier, Pascal 1 Wear, Keith A. 2 Waters, Kendall R. 3; Affiliation: 1: Université Paris VI, Laboratoire d'Imagerie Paramétrique 2: US Food and Drug Administration, Center for Devices and Radiological Health 3: Volcano Corp.; Source Info: Jun2008, Vol. 55 Issue 6, p1177; Subject Term: NUMERICAL analysis; Subject Term: WAVES (Physics); Number of Pages: 2p; Document Type: Article
L3 - 10.1109/TUFFC.2008.781
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baron, Paul A.
AU - Deye, Gregory J.
AU - Chen, Bean T.
AU - Schwegler-Berry, Diane E.
AU - Shvedova, Anna A.
AU - Castranova, Vincent
T1 - Aerosolization of Single-Walled Carbon Nanotubes for an Inhalation Study.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2008/06//
VL - 20
IS - 8
M3 - Article
SP - 751
EP - 760
SN - 08958378
AB - Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities because of high interest in applications resulting from their unique properties. Because of potential respiratory exposures during production and handling, inhalation studies are needed to determine potential toxicity. A generation system was designed to produce respirable aerosol at 5 mg/m3 for a 1-wk animal (mouse) exposure. The starting material used in these experiments was as-produced powder from the high pressure carbon monoxide method that was sieved to number 6 mesh (< 2.3 mm). An acoustic feeder system was developed that handled the SWCNT powder without causing compaction of the material. The feed rate was adjustable, allowing output concentrations as high as 25 mg/m3. The powder particles were reduced in size using a mill that produced high shear forces, tearing the agglomerates apart. The resulting aerosol was size-separated using a settling chamber and two cyclones to produce a respirable aerosol. The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Carbon monoxide
KW - Poisonous gases -- Toxicology
KW - Combustion gases -- Toxicology
KW - Cyclones
KW - Carbon nanotubes
N1 - Accession Number: 32707480; Baron, Paul A. 1; Deye, Gregory J. 1; Chen, Bean T. 2; Schwegler-Berry, Diane E. 2; Shvedova, Anna A. 2; Castranova, Vincent 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Jun2008, Vol. 20 Issue 8, p751; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Carbon monoxide; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Combustion gases -- Toxicology; Thesaurus Term: Cyclones; Subject Term: Carbon nanotubes; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 3 Diagrams, 4 Graphs; Document Type: Article
L3 - 10.1080/08958370801975303
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Monheit, Alan C.
AU - Vistnes, Jessica Primoff
T1 - Health Insurance Enrollment Decisions: Preferences for Coverage, Worker Sorting, and Insurance Take-Up.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2008///Summer2008
VL - 45
IS - 2
M3 - Article
SP - 153
EP - 167
SN - 00469580
AB - The weak response by the uninsured to initiatives encouraging voluntary enrollment in health insurance has raised concerns regarding the extent to which the uninsured value insurance. This concern is also relevant for proposals to mandate health insurance coverage since workers will suffer welfare losses if compelled to purchase coverage they perceive to be of little value. To address this issue, we use the 2001 Medical Expenditure Panel Survey to examine decisions by single workers to seek out and enroll in employer-sponsored insurance. We find that single workers with weak or uncertain preferences for health insurance are less likely to have jobs that offer coverage or to enroll in coverage when offered. Our results suggest a dual approach to expanding coverage that includes both subsidies and educational efforts regarding the value of health insurance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - MEDICAL care
KW - DOMESTIC economic assistance
KW - PUBLIC welfare
KW - DECISION making
KW - INSURANCE policies
KW - GOVERNMENT aid
KW - MEDICALLY uninsured persons
KW - MEDICAL care costs
N1 - Accession Number: 34229898; Monheit, Alan C. 1; Email Address: monheiac@umdnj.edu; Vistnes, Jessica Primoff 2; Affiliations: 1: Professor of Health Economics, Department of Health Systems and Policy, School of Public Health, University of Medicine and Dentistry of New Jersey (UMDNJ); 2: Senior Economist, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality; Issue Info: Summer2008, Vol. 45 Issue 2, p153; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICAL care; Thesaurus Term: DOMESTIC economic assistance; Thesaurus Term: PUBLIC welfare; Thesaurus Term: DECISION making; Thesaurus Term: INSURANCE policies; Thesaurus Term: GOVERNMENT aid; Thesaurus Term: MEDICALLY uninsured persons; Subject Term: MEDICAL care costs; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; Number of Pages: 15p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Sung, Kidon
AU - Khan, Saeed A.
AU - Nawaz, Mohamed S.
T1 - Genetic diversity of Tn1546-like elements in clinical isolates of vancomycin-resistant enterococci
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2008/06//
VL - 31
IS - 6
M3 - Article
SP - 549
EP - 554
SN - 09248579
AB - Abstract: We have investigated the genetic diversity of Tn1546 among 17 vancomycin-resistant enterococci (VRE) isolates of Enterococcus faecium. Most of these multidrug-resistant strains harboured plasmids of 2kb to >300kb in size. The vancomycin resistance marker vanA was located on both the plasmid and the chromosomal DNA. VRE isolates 18 and 22 failed to amplify the orf1-IRR and orf2-IRR but contained the orf1 and orf2. VRE3 failed to amplify the orf1, orf2, vanR and vanS, but still yielded a larger than expected (4.4kb vs. 2.3kb) vanSH amplicon. VRE9, 10, 21 and 22 also yielded larger (5.5kb) vanSH amplicons; all others yielded 4.0kb vanSH amplicons. Sequence analysis of the vanSH amplicons from VRE9, 10, 21 and 22 revealed the presence of IS1251 between the vanS and vanH genes in these isolates. The observed vanSH amplicon from VRE3 contained orf31, orf30 and orf29 of the plasmid pRUM followed by the vanHAXYZ region of Tn1546. Translocation of Tn1546 to a pRUM-like plasmid in VRE3 resulted in the loss of its orf1, orf2, vanR and vanS elements and a loss of the orf32 of pRUM, leading to a unique structural arrangement of vanA elements that is hitherto unknown. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mobile genetic elements
KW - Molecular genetics
KW - Enterococcus
KW - Genes
KW - Hybridisation
KW - Insertion element
KW - Transposon
KW - Van operon
N1 - Accession Number: 32074431; Sung, Kidon 1; Khan, Saeed A.; Email Address: saeed.khan@fda.hhs.gov; Nawaz, Mohamed S. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA; Issue Info: Jun2008, Vol. 31 Issue 6, p549; Thesaurus Term: Mobile genetic elements; Subject Term: Molecular genetics; Subject Term: Enterococcus; Subject Term: Genes; Author-Supplied Keyword: Hybridisation; Author-Supplied Keyword: Insertion element; Author-Supplied Keyword: Transposon; Author-Supplied Keyword: Van operon; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2008.01.030
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105678019
T1 - The PCL: YV and recidivism in male and female juveniles: a follow-up into young adulthood.
AU - Vincent GM
AU - Odgers CL
AU - McCormick AV
AU - Corrado RR
Y1 - 2008/06//
N1 - Accession Number: 105678019. Language: English. Entry Date: 20081031. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Special Interest: Psychiatry/Psychology. NLM UID: 7806862.
KW - Antisocial Personality Disorder -- Psychosocial Factors
KW - Juvenile Delinquency -- Psychosocial Factors
KW - Juvenile Delinquency -- Rehabilitation
KW - Psychological Tests
KW - Violence -- Psychosocial Factors
KW - Adolescence
KW - British Columbia
KW - Child
KW - Female
KW - Logistic Regression
KW - Male
KW - Models, Psychological
KW - Multivariate Analysis
KW - Prisoners -- Psychosocial Factors
KW - Prospective Studies
KW - Reproducibility of Results
KW - Risk Assessment
KW - Sex Factors
KW - Human
SP - 287
EP - 296
JO - International Journal of Law & Psychiatry
JF - International Journal of Law & Psychiatry
JA - INT J LAW PSYCHIATRY
VL - 31
IS - 3
PB - Pergamon Press - An Imprint of Elsevier Science
SN - 0160-2527
AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Gina.Vincent@unassmed.edu
U2 - PMID: 18534679.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - CHEN, YUEHUI
AU - CHEN, FENG
AU - YANG, JACK Y.
AU - YANG, MARY QU
T1 - ENSEMBLE VOTING SYSTEM FOR MULTICLASS PROTEIN FOLD RECOGNITION.
JO - International Journal of Pattern Recognition & Artificial Intelligence
JF - International Journal of Pattern Recognition & Artificial Intelligence
Y1 - 2008/06//
VL - 22
IS - 4
M3 - Article
SP - 747
EP - 763
PB - World Scientific Publishing Company
SN - 02180014
AB - Protein structure classification is an important issue in understanding the associations between sequence and structure as well as possible functional and evolutionary relationships. Recently structural genomes initiatives and other high-throughput experiments have populated the biological databases at a rapid pace. In this paper, three types of classifiers, k nearest neighbors, class center and nearest neighbor and probabilistic neural networks and their homogenous ensemble for multiclass protein fold recognition problem are evaluated firstly, and then a heterogenous ensemble Voting System is designed for the same problem. The different features and/or their combinations extracted from the protein fold dataset are used in these classification models. The heterogenous classification results are then put into a voting system to get the final result. The experimental results show that the proposed method can improve prediction accuracy by 4%–10% on a benchmark dataset containing 27 SCOP folds. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Pattern Recognition & Artificial Intelligence is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAL networks (Computer science)
KW - ARTIFICIAL intelligence
KW - PROTEIN folding
KW - GENOMES
KW - GENOMICS
KW - CLASSIFICATION
KW - ensemble learning
KW - particle swarm optimization (PSO)
KW - probabilistic neural networks
KW - Protein fold recognition
KW - Tabu search
N1 - Accession Number: 33193263; CHEN, YUEHUI 1; Email Address: yhchen@ujn.edu.cn CHEN, FENG 2; Email Address: chenfeng_ci@163.com YANG, JACK Y. 3; Email Address: jyang@bwh.harvard.edu YANG, MARY QU 4; Email Address: yangma@mail.NIH.gov; Affiliation: 1: School of Information Science and Engineering, University of Jinan, 106 Jiwei Road, 250022 Jinan, P. R. China 2: School of Software, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China 3: Harvard Medical School, Harvard University, P.O. Box 400888, Cambridge, MA 02140, USA 4: National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services Bethesda, MD 20852, USA; Source Info: Jun2008, Vol. 22 Issue 4, p747; Subject Term: NEURAL networks (Computer science); Subject Term: ARTIFICIAL intelligence; Subject Term: PROTEIN folding; Subject Term: GENOMES; Subject Term: GENOMICS; Subject Term: CLASSIFICATION; Author-Supplied Keyword: ensemble learning; Author-Supplied Keyword: particle swarm optimization (PSO); Author-Supplied Keyword: probabilistic neural networks; Author-Supplied Keyword: Protein fold recognition; Author-Supplied Keyword: Tabu search; Number of Pages: 17p; Illustrations: 2 Diagrams, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luxbacher, Kray
AU - Westman, Erik
AU - Swanson, Peter
AU - Karfakis, Mario
T1 - Three-dimensional time-lapse velocity tomography of an underground longwall panel
JO - International Journal of Rock Mechanics & Mining Sciences
JF - International Journal of Rock Mechanics & Mining Sciences
Y1 - 2008/06//
VL - 45
IS - 4
M3 - Article
SP - 478
EP - 485
SN - 13651609
AB - Abstract: Three-dimensional velocity tomograms were generated to image the stress redistribution around an underground coal longwall panel to produce a better understanding of the mechanisms that lead to ground failure, especially rockbursts. Mining-induced microseismic events provided passive sources for the three-dimensional velocity tomography. Surface-mounted geophones monitored microseismic activity for 18 days. Eighteen tomograms were generated and high-velocity regions correlated with high abutment stresses predicted by numerical modeling. Additionally, the high-velocity regions were observed to redistribute as the longwall face retreated, indicating that velocity tomography may be an appropriate technology for monitoring stress redistribution in underground mines. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Rock Mechanics & Mining Sciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOMOGRAPHY
KW - CROSS-sectional imaging
KW - GEOMETRIC tomography
KW - TECHNOLOGY
KW - Coal
KW - Longwall
KW - Rockbursts
KW - Stress
KW - Tomography
KW - Velocity
N1 - Accession Number: 31307576; Luxbacher, Kray 1; Email Address: kraylux@vt.edu Westman, Erik 1 Swanson, Peter 2 Karfakis, Mario 1; Affiliation: 1: Department of Mining & Minerals Engineering, Virginia Tech., Blacksburg, VA 24061-0239, USA 2: Spokane Research Laboratory, National Institute for Occupational Safety and Health, Spokane, WA 99207, USA; Source Info: Jun2008, Vol. 45 Issue 4, p478; Subject Term: TOMOGRAPHY; Subject Term: CROSS-sectional imaging; Subject Term: GEOMETRIC tomography; Subject Term: TECHNOLOGY; Author-Supplied Keyword: Coal; Author-Supplied Keyword: Longwall; Author-Supplied Keyword: Rockbursts; Author-Supplied Keyword: Stress; Author-Supplied Keyword: Tomography; Author-Supplied Keyword: Velocity; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijrmms.2007.07.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Tsong
AU - Joanne Zhang
T1 - Guest Editors' Notes on Statistical Issues in Design and Analysis of Thorough QTc Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/06//
VL - 18
IS - 3
M3 - Article
SP - 405
EP - 407
PB - Taylor & Francis Ltd
SN - 10543406
AB - The article discusses various reports published within the issue, including one on the design of thorough QTc clinical trials and another on QT data following placebo and moxifloxacin dosing in thorough QT studies.
KW - CLINICAL trials
KW - MEDICAL research
N1 - Accession Number: 31963540; Yi Tsong 1; Email Address: yi.tsong@fda.hhs.gov Joanne Zhang 1; Affiliation: 1: Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.; Source Info: Jun2008, Vol. 18 Issue 3, p405; Subject Term: CLINICAL trials; Subject Term: MEDICAL research; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10543400802029509
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joanne Zhang
AU - Machado, Stella G.
T1 - Statistical Issues Including Design and Sample Size Calculation in Thorough QT/QTc Studies.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/06//
VL - 18
IS - 3
M3 - Article
SP - 451
EP - 467
PB - Taylor & Francis Ltd
SN - 10543406
AB - After several drugs were removed from the market in recent years because of death due to ventricular tachycardia resulting from drug-induced QT prolongation (Khongphatthanayothin et al., 1998; Lasser et al., 2002; Pratt et al., 1994; Wysowski et al., 2001), the ICH Regulatory agencies requested all sponsors of new drugs to conduct a clinical study, named a Thorough QT/QTc (TQT) study, to assess any possible QT prolongation due to the study drug. The final version of the ICH E14 guidance (ICH, 2005) for "The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs" was released in May 2005. The purpose of the ICH E14 guidance (ICH, 2005) is to provide recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the potential of a drug to delay cardiac repolarization. The guideline, however, is not specific on several issues. In this paper, we try to address some statistical issues, including study design, primary statistical analysis, assay sensitivity analysis, and the calculation of the sample size for a TQT study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARRHYTHMIA
KW - VENTRICULAR tachycardia
KW - SAMPLING (Statistics)
KW - TACHYCARDIA
KW - SAMPLE size (Statistics)
KW - QT/QTc interval
KW - Sample size
KW - Study design
KW - Thorough QT/QTc (TQT) study
N1 - Accession Number: 31963537; Joanne Zhang 1; Email Address: Joanne.Zhang@fda.hhs.gov Machado, Stella G. 1; Affiliation: 1: Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.; Source Info: Jun2008, Vol. 18 Issue 3, p451; Subject Term: ARRHYTHMIA; Subject Term: VENTRICULAR tachycardia; Subject Term: SAMPLING (Statistics); Subject Term: TACHYCARDIA; Subject Term: SAMPLE size (Statistics); Author-Supplied Keyword: QT/QTc interval; Author-Supplied Keyword: Sample size; Author-Supplied Keyword: Study design; Author-Supplied Keyword: Thorough QT/QTc (TQT) study; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 17p; Illustrations: 13 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400802020938
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joanne Zhang
T1 - Testing for Positive Control Activity in a Thorough QTc Study.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/06//
VL - 18
IS - 3
M3 - Article
SP - 517
EP - 528
PB - Taylor & Francis Ltd
SN - 10543406
AB - The ICH E14 guidance (ICH, 2005) recommend that a concurrent positive control should be included in a thorough QTc clinical trial to validate the study. The ICH E14 guidance (ICH, 2005) state that "The positive control should have an effect on the mean QTc interval of about 5 ms (i.e., an effect that is close to the QTc effect that represents the threshold of regulatory concern, around 5 ms)". This task may be carried out through some statistical tests. The current practice is to test at each time point where QT measurements are collected. This method is usually not efficient. In this article, I discuss two types of statistical procedures. The first one is a local statistical test to make a time-point-specific claim, i.e., to claim a mild QTc effect due to the positive control at some specific time points. A different approach, named as a global test, is also proposed, to make a general claim that the mean difference of the positive control and placebo after baseline adjustment will be about 5 ms without specifying at which time points. An example will be used to illustrate how to apply the two procedures. How to best allocate sample size in a parallel QTc study is also discussed in this paper. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - PLACEBOS (Medicine)
KW - MEDICAL experimentation on humans
KW - CLINICAL medicine
KW - MEDICAL research
KW - Assay sensitivity
KW - QTc interval
KW - Statistical testing
KW - Thorough QTc study
N1 - Accession Number: 31963532; Joanne Zhang 1; Email Address: Joanne.Zhang@fda.hhs.gov; Affiliation: 1: Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.; Source Info: Jun2008, Vol. 18 Issue 3, p517; Subject Term: CLINICAL trials; Subject Term: PLACEBOS (Medicine); Subject Term: MEDICAL experimentation on humans; Subject Term: CLINICAL medicine; Subject Term: MEDICAL research; Author-Supplied Keyword: Assay sensitivity; Author-Supplied Keyword: QTc interval; Author-Supplied Keyword: Statistical testing; Author-Supplied Keyword: Thorough QTc study; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400801995478
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Tsong
AU - Jinglin Zhong
AU - Wen Jen Chen
T1 - Validation Testing in Thorough QT/QTc Clinical Trials.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/06//
VL - 18
IS - 3
M3 - Article
SP - 529
EP - 541
PB - Taylor & Francis Ltd
SN - 10543406
AB - In order to validate the results of a thorough QT/QTc (the duration of depolarization and repolarization of ventricles or the duration corrected for heart rate) clinical trial, ICH E14 recommended to include a concurrent positive control treatment in the trial. It further recommended that validation is achieved if the positive control has an effect on the mean QT/QTc interval of about 5 ms. Zhang (2008) discussed the intersection-union test approach for testing the validation hypotheses and an alternative global average test approach. In this article, we further discuss the difference and relationship of the two sets of hypotheses and the difference in the efficiencies of the two approaches. We conclude that validation can be achieved if either one test rejects the null hypotheses without inflating the family-wise Type I error rate. However, using both approaches may improve the efficiency in validation assessment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - MEDICAL statistics
KW - CLINICAL medicine
KW - MEDICAL research
KW - HEART diseases -- Treatment
KW - HEART beat
KW - Assay sensitivity
KW - Controlling Type I error rate
KW - QT prolongation
KW - Statistical testing
N1 - Accession Number: 31963547; Yi Tsong 1; Email Address: yi.tsong@cder.hhs.gov Jinglin Zhong 1 Wen Jen Chen 1; Affiliation: 1: Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.; Source Info: Jun2008, Vol. 18 Issue 3, p529; Subject Term: CLINICAL trials; Subject Term: MEDICAL statistics; Subject Term: CLINICAL medicine; Subject Term: MEDICAL research; Subject Term: HEART diseases -- Treatment; Subject Term: HEART beat; Author-Supplied Keyword: Assay sensitivity; Author-Supplied Keyword: Controlling Type I error rate; Author-Supplied Keyword: QT prolongation; Author-Supplied Keyword: Statistical testing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Illustrations: 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1080/10543400801995486
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Tsong
AU - Meiyu Shen
AU - Jinglin Zhong
AU - Joanne Zhang
T1 - Statistical Issues of QT Prolongation Assessment Based on Linear Concentration Modeling.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/06//
VL - 18
IS - 3
M3 - Article
SP - 564
EP - 584
PB - Taylor & Francis Ltd
SN - 10543406
AB - The ICH (2005) defined drug-induced prolongation of QT interval, i.e., the duration of depolarization and repolarization of ventricles, as evidenced by an upper bound of the 95% confidence interval around the mean effect on QTc (QT corrected for heart rate) of 10 ms. Furthermore, it defined that a negative thorough QT/QTc study is one in which the upper bound of the 95% one-sided confidence interval for the largest time-matched mean effect of the drug on the QTc interval excludes 10 ms. This objective leads to the application of intersection-union tests by testing the mean difference between test treatment and placebo of QTc change from baseline at each of the matched time points at which the observations are collected. The nature of the higher false positive rate due to more observational time points leads to the concern of study efficiency. Based on the concept of clinical pharmacology, a concentration-response modeling approach is often adopted to assess the prolongation size of QTc interval induced by a drug without carefully examining the validity of the assumptions involved. In most of the applications, the model is assumed either to be linear, log-linear, or logistic. The supporter of the modeling often emphasizes the advantage of power improvement and reduction in estimation error. However, it has been often pointed out by statisticians and pharmacologists that modeling under an invalid uniformity assumption across study population often leads to severe bias in testing and estimation. In this article, we examine data sets of New Drug Applications to illustrate the bias and lack of validity of the linearity assumptions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL statistics
KW - PHARMACOLOGY
KW - CLINICAL medicine
KW - CLINICAL pharmacology
KW - HEART beat
KW - Bias
KW - Concentration-response relationship
KW - Linear model
KW - Underestimate
N1 - Accession Number: 31963544; Yi Tsong 1; Email Address: yi.tsong@cder.hhs.gov Meiyu Shen 1 Jinglin Zhong 1 Joanne Zhang 1; Affiliation: 1: Division of Biometrics VI, Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.; Source Info: Jun2008, Vol. 18 Issue 3, p564; Subject Term: MEDICAL statistics; Subject Term: PHARMACOLOGY; Subject Term: CLINICAL medicine; Subject Term: CLINICAL pharmacology; Subject Term: HEART beat; Author-Supplied Keyword: Bias; Author-Supplied Keyword: Concentration-response relationship; Author-Supplied Keyword: Linear model; Author-Supplied Keyword: Underestimate; Number of Pages: 21p; Illustrations: 3 Charts, 21 Graphs; Document Type: Article
L3 - 10.1080/10543400801995502
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shiew-Mei Huang
AU - Strong, John M.
AU - Lei Zhang
AU - Reynolds, Kellie S.
AU - Nallani, Srikanth
AU - Temple, Robert
AU - Abraham, Ophia
AU - Habet, Sayed Al
AU - Baweja, Raman K.
AU - Burckart, Gilbert J.
AU - Sang Chung
AU - Colangelo, Philip
AU - Frucht, David
AU - Green, Martin D.
AU - Hepp, Paul
AU - Karnaukhova, Elena
AU - Hon-Sum Ko
AU - Jan G-Ik Lee
AU - Marroum, Patrick J.
AU - Norden, Janet M.
T1 - New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2008/06//
VL - 48
IS - 6
M3 - Article
SP - 662
EP - 670
SN - 00912700
AB - Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the publication of the US Food and Drug Administration's (FDA's) first in vitro and in vivo drug interaction guidance documents in 1997 and 1999, researchers and clinicians have gained a better understanding of drug interactions. This knowledge has enabled the FDA and the industry to progress and begin to overcome these challenges. The FDA has continued its efforts to evaluate methodologies to study drug interactions and communicate recommendations regarding the conduct of drug interaction studies, particularly for CYP-based and transporter-based drug interactions, to the pharmaceutical industry. A drug interaction Web site was established to document the FDA'S current under- standing of drug interactions (http://www.fda.gov/cder/drug/druglnteractions/default.htm). This report provides an overview of the evolution of the drug interaction guidances, includes a synopsis of the steps taken by the FDA to revise the original drug interaction guidance documents, and summarizes and highlights updated sections in the current guidance document, Drug Interaction Studies—Study Design, Data Analysis, and Implications for Dosing and Labeling. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG interactions
KW - ENZYMES
KW - DRUG development
KW - UNITED States
KW - cytochrome P450 enzymes
KW - Drug interactions
KW - induction
KW - inhibition
KW - P-glycoprotein
KW - pharmacogenetics
KW - transporter proteins
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 34182165; Shiew-Mei Huang 1 Strong, John M. 2 Lei Zhang 1 Reynolds, Kellie S. 1 Nallani, Srikanth 1 Temple, Robert 3 Abraham, Ophia 1 Habet, Sayed Al 1 Baweja, Raman K. 1 Burckart, Gilbert J. 4 Sang Chung 1 Colangelo, Philip 1 Frucht, David 2 Green, Martin D. 5 Hepp, Paul 1 Karnaukhova, Elena 6 Hon-Sum Ko 6 Jan G-Ik Lee 1 Marroum, Patrick J. 1 Norden, Janet M. 3; Affiliation: 1: Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland 2: Office of Pharmaceutical Science, US Food and Drug Administration, Silver Spring, Maryland 3: Office of Medical Policy, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 4: Department of Pharmacy, University of Southern California, Los Angeles, California 5: Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland 6: Office of Blood Research and Review, US Food and Drug Administration, Bethesda, Maryland; Source Info: Jun2008, Vol. 48 Issue 6, p662; Subject Term: DRUG interactions; Subject Term: ENZYMES; Subject Term: DRUG development; Subject Term: UNITED States; Author-Supplied Keyword: cytochrome P450 enzymes; Author-Supplied Keyword: Drug interactions; Author-Supplied Keyword: induction; Author-Supplied Keyword: inhibition; Author-Supplied Keyword: P-glycoprotein; Author-Supplied Keyword: pharmacogenetics; Author-Supplied Keyword: transporter proteins; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1177/0091270007312153
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reuter, Gábor
AU - Pankovics, Péter
AU - Szűcs, György
T1 - Genetic drift of norovirus genotype GII-4 in seven consecutive epidemic seasons in Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2008/06//
VL - 42
IS - 2
M3 - Article
SP - 135
EP - 140
SN - 13866532
AB - Abstract: Background: Noroviruses are common pathogens in human gastroenteritis outbreaks worldwide. They belong to a genetically diverse group of RNA viruses with multiple genogroups (G) and genotypes. Genotype GII-4 norovirus (Lordsdale) is the predominant agent in epidemics. Objectives: To investigate the genetic variation in GII-4 strains isolated during seven epidemic seasons in Hungary from November 2000 to June 2007. Study design: Using the prospective epidemiological surveillance of norovirus outbreaks in Hungary, GII-4 strains were selected for further genetic analysis. After phylogenetic analysis, RNA-polymerase (open reading frame 1; ORF1), capsid (ORF2) and the ORF1/ORF2 junction were analysed by RT-PCR and sequencing. Results: Three hundred and seventy-seven (76.8%) of 491 confirmed norovirus outbreaks were caused by genotype GII-4. GII-4 was the predominant genotype in six of the seven epidemic seasons. Four main GII-4 variants – epidemic point mutants – (GII-4-2000, GII-4-2002, GII-4-2004 and GII-4-2006b) were detected, with each variant predominating in two consecutive epidemic seasons. Conclusions: Genotype GII-4 was confirmed as the predominant genetic type in epidemic norovirus seasons in Hungary. Genetic drift successfully promotes the re-emergence of GII-4 variants in the population. The elevated number of norovirus outbreaks in the population predicts the emergence of new GII-4 genetic variants as part of an international epidemic. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GASTROENTERITIS
KW - NOROVIRUSES
KW - RNA viruses
KW - GENETIC research
KW - GASTROINTESTINAL diseases
KW - HUNGARY
KW - Drift
KW - Epidemic
KW - Gastroenteritis
KW - genogroup ( G )
KW - GII-4
KW - Norovirus
KW - open reading frame ( ORF )
KW - phosphate buffered saline ( PBS )
KW - reverse transcription-polymerase chain reaction ( RT-PCR )
KW - ribonucleic acid ( RNA )
KW - Variants
N1 - Accession Number: 32497298; Reuter, Gábor; Email Address: reuter.gabor@baranya.antsz.hu Pankovics, Péter 1 Szűcs, György 1; Affiliation: 1: Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary; Source Info: Jun2008, Vol. 42 Issue 2, p135; Subject Term: GASTROENTERITIS; Subject Term: NOROVIRUSES; Subject Term: RNA viruses; Subject Term: GENETIC research; Subject Term: GASTROINTESTINAL diseases; Subject Term: HUNGARY; Author-Supplied Keyword: Drift; Author-Supplied Keyword: Epidemic; Author-Supplied Keyword: Gastroenteritis; Author-Supplied Keyword: genogroup ( G ); Author-Supplied Keyword: GII-4; Author-Supplied Keyword: Norovirus; Author-Supplied Keyword: open reading frame ( ORF ); Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: reverse transcription-polymerase chain reaction ( RT-PCR ); Author-Supplied Keyword: ribonucleic acid ( RNA ); Author-Supplied Keyword: Variants; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jcv.2008.02.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kadegowda, A. K. G.
AU - Piperova, L. S.
AU - Delmonte, P.
AU - Erdman, R. A.
T1 - Abomasal Infusion of Butterfat Increases Milk Fat in Lactating Dairy Cows.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2008/06//
VL - 91
IS - 6
M3 - Article
SP - 2370
EP - 2379
SN - 00220302
AB - The objective of this study was to compare the effects of abomasal infusion of butterfat containing all fatty acids (FA) present in milk, including the short- and medium-chain FA, with infusion of only the long-chain FA (LCFA) present in milk, on the FA composition and milk fat yield in lactating dairy cows. Eight rumenfistulated Holstein cows, in early lactation (49 ± 20 days in milk) were used in a replicated 4 x 4 Latin square design. Treatments were abomasal infusion of the following: 1) no infusion (control), 2) 400 g/d of butterfat (butterfat), 3) 245 g/d of LCFA (blend of 59% cocoa butter, 36% olive oil, and 5% palm oil) providing 50% of the 16:0 and equivalent amounts of C18 FA as found in 400 g of butterfat, and 4) 100 g/d of conjugated linoleic acid (CLA, negative control), providing 10 g of trans-10, cis-12 CLA. Fat supplements were infused in equal portions 3 times daily at 0800, 1400, and 1800 h during the last 2 wk of each 3-wk experimental period. Daily dry matter intake and milk production were unaffected by the infusion treatments. Butterfat infusion increased milk fat percentage by 14% to 4.26% and milk fat yield by 21% to 1,421 g/d compared with controls (3.74% and 1,178 g/d). Milk fat percentage and fat yield were decreased by 43% by CLA. Milk protein percentage was higher (3.70%) in CLA-infused cows than in control (3.30%), butterfat (3.28%), or LCFA (3.27%) treatments. Although LCFA had no effect on fat synthesis, abomasal infusion of butterfat increased milk fat percentage and yield, suggesting that the availability of short- and medium-chain FA may be a limiting factor for milk fat synthesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dairy Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dairy cattle
KW - Fatty acids
KW - Milk
KW - Milkfat
KW - Lactation
KW - de novo fatty acid
KW - lactating dairy cow
KW - milk fat synthesis
N1 - Accession Number: 32564226; Kadegowda, A. K. G. 1; Piperova, L. S. 1; Delmonte, P. 2; Erdman, R. A. 1; Email Address: erdman@umd.edu; Affiliations: 1: Animal and Avian Sciences Department, University of Maryland, College Park 20742; 2: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20; Issue Info: Jun2008, Vol. 91 Issue 6, p2370; Thesaurus Term: Dairy cattle; Thesaurus Term: Fatty acids; Thesaurus Term: Milk; Subject Term: Milkfat; Subject Term: Lactation; Author-Supplied Keyword: de novo fatty acid; Author-Supplied Keyword: lactating dairy cow; Author-Supplied Keyword: milk fat synthesis; NAICS/Industry Codes: 112120 Dairy Cattle and Milk Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 10p; Illustrations: 7 Charts, 1 Graph; Document Type: Article
L3 - 10.3168/jds.2007-0894
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Klontz, Karl C.
AU - McCarthy, Patric V.
AU - Datta, Atin R.
AU - Lee, Judy O.
AU - Acheson, David W. K.
AU - Brackett, Robert E.
T1 - Role of the U.S. Food and Drug Administration in the Regulatory Management of Human Listeriosis in the United States.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/06//
VL - 71
IS - 6
M3 - Article
SP - 1277
EP - 1286
SN - 0362028X
AB - From 1986 to 2006, the incidence of listeriosis in the United States dropped from approximately seven to three cases per million population, a reduction that most likely reflects the joint efforts of industry, government, consumers, and academia. Herein, we describe the U.S. Food and Drug Administration (FDA) strategy over the past three decades to combat listeriosis. Specifically, we discuss early actions taken to address outbreaks during the 1980s, policy decisions regarding the presence of Listeria monocytogenes in FDA-regulated foods, FDA compliance programs with L. monocytogenes components, enforcement actions to remove L. monocytogenes--contaminated products from the market (i.e., recalls) or to prevent entry of such products into the market (i.e., import detentions and refusals), research milestones, outreach and education efforts, and selected special projects. Evolving demographic trends in the United States may pose a challenge to further reduction of the incidence of listeriosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial diseases
KW - Listeriosis
KW - Health promotion
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 32659911; Klontz, Karl C. 1; Email Address: karl.klontz@fda.hhs.gov; McCarthy, Patric V. 1; Datta, Atin R. 1; Lee, Judy O. 1; Acheson, David W. K. 2; Brackett, Robert E. 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740; 2: Office of the Commissioner, U.S. Food and Drug Administration, Rockville, Maryland 20857, USA; Issue Info: Jun2008, Vol. 71 Issue 6, p1277; Thesaurus Term: Bacterial diseases; Subject Term: Listeriosis; Subject Term: Health promotion; Subject: United States ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 10p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105685897
T1 - Commentary: health and economic development in the Mississippi Delta Region.
AU - Graham GN
Y1 - 2008/06//
N1 - Accession Number: 105685897. Language: English. Entry Date: 20081107. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; USA. NLM UID: 9501928.
KW - Economics
KW - Health Status
KW - Poverty Areas
KW - Midwestern United States
KW - Southeastern United States
SP - 174
EP - 178
JO - Journal of Health & Human Services Administration
JF - Journal of Health & Human Services Administration
JA - J HEALTH HUM SERV ADM
VL - 31
IS - 1
CY - Towson, Maryland
PB - Southern Public Administration Education Foundation
SN - 1079-3739
AD - Office of Minority Health, US Department of Health and Human Services, USA.
U2 - PMID: 18575155.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Naum, Marianna
AU - Brown, Eric W.
AU - Mason-Gamer, Roberta J.
T1 - Is 16S rDNA a Reliable Phylogenetic Marker to Characterize Relationships Below the Family Level in the Enterobacteriaceae?
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
Y1 - 2008/06//
VL - 66
IS - 6
M3 - Article
SP - 630
EP - 642
PB - Springer Science & Business Media B.V.
SN - 00222844
AB - The phylogenetic relationships of multiple enterobacterial species were reconstructed based on 16S rDNA gene sequences to evaluate the robustness of this housekeeping gene in the taxonomic placement of the enteric plant pathogens Erwinia, Brenneria, Pectobacterium, and Pantoea. Four data sets were compiled, two of which consisted of previously published data. The data sets were designed in order to evaluate how 16S rDNA gene phylogenies are affected by the use of different plant pathogen accessions and varying numbers of animal pathogen and outgroup sequences. DNA data matrices were analyzed using maximum likelihood (ML) algorithms, and character support was determined by ML bootstrap and Bayesian analyses. As additional animal pathogen sequences were added to the phylogenetic analyses, taxon placement changed. Further, the phylogenies varied in their placement of the plant pathogen species, and only the genus Pantoea was monophyletic in all four trees. Finally, bootstrap and Bayesian support values were low for most of the nodes, and all nonterminal branches collapsed in strict consensus trees. Inspection of 16S rDNA nucleotide alignments revealed several highly variable blocks punctuated by regions of conserved sequence. These data suggest that 16S rDNA, while effective for both species-level and family-level phylogenetic reconstruction, may underperform for genus-level phylogenetic analyses in the Enterobacteriaceae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Molecular Evolution is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - ERWINIA
KW - DNA
KW - PHYLOGENY
KW - GENES
KW - PATHOGENIC microorganisms
KW - 16S rDNA
KW - Enterobacteriaceae
KW - Erwinia
KW - GARLI
KW - Housekeeping genes
KW - Phylogenetic analysis
N1 - Accession Number: 32960651; Naum, Marianna 1,2; Email Address: marianna.naum@fda.hhs.gov Brown, Eric W. 3 Mason-Gamer, Roberta J. 1; Affiliation: 1: Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA 2: Center for Food Safety and Applied Nutrition, FDA, 5100 Paint Branch Parkway, HFS-712, College Park, MD 20740, USA 3: Division of Microbiology, Center for Food Safety and Applied Nutrition, FDA, College Park, MD 20740, USA; Source Info: Jun2008, Vol. 66 Issue 6, p630; Subject Term: ENTEROBACTERIACEAE; Subject Term: ERWINIA; Subject Term: DNA; Subject Term: PHYLOGENY; Subject Term: GENES; Subject Term: PATHOGENIC microorganisms; Author-Supplied Keyword: 16S rDNA; Author-Supplied Keyword: Enterobacteriaceae; Author-Supplied Keyword: Erwinia; Author-Supplied Keyword: GARLI; Author-Supplied Keyword: Housekeeping genes; Author-Supplied Keyword: Phylogenetic analysis; Number of Pages: 13p; Illustrations: 5 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1007/s00239-008-9115-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32960651&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dobretsova, Anna
AU - Johnson, Jennifer W.
AU - Jones, Richard C.
AU - Edmondson, Ricky D.
AU - Wight, Patricia A.
T1 - Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene.
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
Y1 - 2008/06//
VL - 105
IS - 5
M3 - Article
SP - 1979
EP - 1995
PB - Wiley-Blackwell
SN - 00223042
AB - The myelin proteolipid protein gene ( Plp1) encodes the most abundant protein found in CNS myelin, accounting for nearly one-half of the total protein. Its expression in oligodendrocytes is developmentally regulated – peaking during the active myelination period of CNS development. Previously, we have identified a novel enhancer (designated ASE) in intron 1 DNA that appears to be important in mediating the surge of Plp1 gene activity during the active myelination period. Evidence suggests that the ASE participates in the formation of a specialized multi-protein/DNA complex called an enhanceosome. The current study describes an optimized, five-step, DNA affinity chromatography purification procedure to purify nuclear proteins from mouse brain that bind to the 85-bp ASE sequence, specifically. Electrophoretic mobility shift assay analysis demonstrated that specific DNA-binding activity was retained throughout the purification procedure, resulting in concomitant enrichment of nucleoprotein complexes. Identification of the purported regulatory factors was achieved through mass spectrometry analysis and included over 20 sequence-specific DNA-binding proteins. Supplementary western blot analyses to determine which of these sequence-specific factors are present in oligodendrocytes, and their developmental and regional expression in whole brain, suggest that Purα and Purβ rank highest among the candidate factors as constituents of the multi-protein complex formed on the ASE. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neurochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - MYELIN proteins
KW - GENES
KW - OLIGODENDROGLIA
KW - DNA
KW - CHROMATOGRAPHIC analysis
KW - DNA affinity chromatography
KW - DNA-binding proteins
KW - enhanceosome
KW - intronic enhancer
KW - mass spectrometry
KW - multi-protein complex
KW - myelin proteolipid protein gene
KW - proteomics
N1 - Accession Number: 32000317; Dobretsova, Anna 1 Johnson, Jennifer W. 2 Jones, Richard C. 3 Edmondson, Ricky D. 4 Wight, Patricia A. 1; Email Address: pwight@uams.edu; Affiliation: 1: Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 2: Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 3: Food and Drug Administration, National Center for Toxicological Research (FDA/NCTR), Jefferson, Arkansas, USA. 4: Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Source Info: Jun2008, Vol. 105 Issue 5, p1979; Subject Term: PROTEOMICS; Subject Term: MYELIN proteins; Subject Term: GENES; Subject Term: OLIGODENDROGLIA; Subject Term: DNA; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: DNA affinity chromatography; Author-Supplied Keyword: DNA-binding proteins; Author-Supplied Keyword: enhanceosome; Author-Supplied Keyword: intronic enhancer; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: multi-protein complex; Author-Supplied Keyword: myelin proteolipid protein gene; Author-Supplied Keyword: proteomics; Number of Pages: 17p; Illustrations: 1 Color Photograph, 3 Black and White Photographs, 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1471-4159.2008.05288.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32000317&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Old, Leo
AU - Methner, Mark M.
T1 - Engineering Case Reports.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/06//
VL - 5
IS - 6
M3 - Article
SP - 63
EP - 69
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents a case study in which process-specific emissions during the production of engineered nanomaterials (EMNs) was evaluated in a company. It was noted that during reactor clean out of slag and waste, ENMs were released in production area and resulted in exposure of workers. It led the company to buy local exhaust ventilation (LEV) unit to control ENM emissions.
KW - Emissions (Air pollution)
KW - Business enterprises
KW - Exhaust systems
KW - Nanostructured materials
KW - Case studies
KW - Employees
N1 - Accession Number: 75127832; Old, Leo; Methner, Mark M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jun2008, Vol. 5 Issue 6, p63; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Business enterprises; Thesaurus Term: Exhaust systems; Subject Term: Nanostructured materials; Subject Term: Case studies; Subject Term: Employees; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 7p; Illustrations: 4 Black and White Photographs, 2 Charts; Document Type: Article
L3 - 10.1080/15459620802059393
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127832&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yucesoy, Berran
AU - Kurzius-Spencer, Margaret
AU - Johnson, Victor J.
AU - Fluharty, Kara
AU - Kashon, Michael L.
AU - Guerra, Stefano
AU - Luster, Michael I.
AU - Burgess, Jeffrey L.
T1 - Association of Cytokine Gene Polymorphisms With Rate of Decline in Lung Function.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/06//
VL - 50
IS - 6
M3 - Article
SP - 642
EP - 648
SN - 10762752
AB - The article presents a study concerning the prevalence of chronic obstructive pulmonary disease (COPD) associated with 1-second forced expiratory volume FEV1. It examines whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in FEV1. It notes that functional polymorphisms in the TGFβ1, IL-1 β, IL-13, and IL-8 genes were investigated in 374 active firefighters with pulmonary function tests. The study found a protective effect between the presence of the TGFβ1 — 509TT genotype and rate of decline in FEV1. Moreover, it found that FEV1 decline was highly associated with COPD.
KW - OBSTRUCTIVE lung diseases
KW - GENETIC polymorphisms
KW - GENETIC disorders
KW - LUNG diseases
KW - HUMAN chromosomes
KW - PULMONARY function tests
KW - CYTOKINES
KW - IMMUNE response -- Regulation
KW - CHROMOSOME polymorphism
N1 - Accession Number: 32777373; Yucesoy, Berran 1; Email Address: byucesoy@cdc.gov Kurzius-Spencer, Margaret 2 Johnson, Victor J. 1 Fluharty, Kara 1 Kashon, Michael L. 1 Guerra, Stefano Luster, Michael I. 1 Burgess, Jeffrey L. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV 2: Environmental and Occupational Health, University of Arizona, Tucson, AZ; Source Info: Jun2008, Vol. 50 Issue 6, p642; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC disorders; Subject Term: LUNG diseases; Subject Term: HUMAN chromosomes; Subject Term: PULMONARY function tests; Subject Term: CYTOKINES; Subject Term: IMMUNE response -- Regulation; Subject Term: CHROMOSOME polymorphism; Number of Pages: 7p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1097/JOM.0b013e31816515e1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32777373&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105646781
T1 - Association of cytokine gene polymorphisms with rate of decline in lung function.
AU - Yucesoy B
AU - Kurzius-Spencer M
AU - Johnson VJ
AU - Fluharty K
AU - Kashon ML
AU - Guerra S
AU - Luster MI
AU - Burgess JL
Y1 - 2008/06//
N1 - Accession Number: 105646781. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Note: CEU online. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Supported in part by an Interagency Agreement with the NIEHS, Division of Intramural Research (Y1-ES-0001), and by Training Grant T42/CCT918726 from the CDC/National Institute for Occupational Safety and Health. NLM UID: 9504688.
KW - Cytokines
KW - Forced Expiratory Volume
KW - Polymorphism, Genetic
KW - Arizona
KW - Blacks
KW - Descriptive Statistics
KW - DNA
KW - Education, Continuing (Credit)
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Hispanics
KW - Male
KW - Multiple Regression
KW - One-Way Analysis of Variance
KW - P-Value
KW - Respiratory Function Tests
KW - Smoking -- Epidemiology
KW - Whites
KW - Human
SP - 642
EP - 648
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 50
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE:: To investigate whether genetic variants involved in cytokine expression are associated with the age-related rate of decline in forced expiratory volume in 1 second (FEV1). METHODS:: Functional polymorphisms in the TNFalpha, TGFbeta1, IL-1beta, IL-1RN, IL-13, and IL-8 genes were investigated in 374 active firefighters with at least five pulmonary function tests. RESULTS:: A protective effect was found between the presence of the TGFbeta1 -509 TT genotype and rate of decline in FEV1 (P = 0.043). Carrying an A allele at TNFalpha -308 (P = 0.010) and GG genotype at TNFalpha -238 (P = 0.028) was associated with a more rapid rate of FEV1 decline. The TNFalpha -308A/-238G haplotype was also associated with an increased rate of decline as compared with the other haplotypes. CONCLUSIONS:: Interindividual variability in progressive decline in FEV1 may be explained in part by genetic variations within genes involved in inflammatory responses.
SN - 1076-2752
AD - National Institute for Occupational Safety and Health, Morgantown, WV
U2 - PMID: 18545091.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105646781&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105646786
T1 - Mental health outcomes in police personnel after Hurricane Katrina.
AU - West C
AU - Bernard B
AU - Mueller C
AU - Kitt M
AU - Driscoll R
AU - Tak S
Y1 - 2008/06//
N1 - Accession Number: 105646786. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). NLM UID: 9504688.
KW - Depression -- Epidemiology
KW - Natural Disasters
KW - Police -- Psychosocial Factors -- Louisiana
KW - Stress Disorders, Post-Traumatic -- Epidemiology
KW - Adult
KW - Aged
KW - Center for Epidemiological Studies Depression Scale
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Louisiana
KW - Male
KW - Middle Age
KW - P-Value
KW - Psychological Tests
KW - Questionnaires
KW - Regression
KW - Self Report
KW - Human
SP - 689
EP - 695
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 50
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE:: We examined symptoms of depression and posttraumatic stress disorder (PTSD) among New Orleans Police Department (NOPD) personnel who provided law enforcement and relief services to affected communities following Hurricane Katrina. METHODS:: We conducted a cross-sectional survey of mental health outcomes related to personal and work-related exposures of police personnel 8 weeks after the Hurricane. RESULTS:: Of the 912 police personnel who completed the questionnaire, 227 (26%) reported symptoms consistent with depression and 170 (19%) reported symptoms consistent with PTSD. Risk factors associated with PTSD include recovery of bodies, crowd control, assault, and injury to a family member. Depressive symptoms were associated with rare family contact, uninhabitable home, isolation from the NOPD, assault, and injury to a family member. CONCLUSIONS:: Police personnel reported symptoms of PTSD and depression associated with work-related and personal factors following Hurricane Katrina.
SN - 1076-2752
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio; cawest@cdc.gov
U2 - PMID: 18545096.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105646786&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105810002
T1 - Motive for nonmedical use of prescription pain relievers in the national survey on drug use and health.
AU - Colliver JD
AU - Gfroerer JC
Y1 - 2008/06//
N1 - Accession Number: 105810002. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Zacny JP, Lichtor SA, Zacny James P, Lichtor Stephanie A. Nonmedical use of prescription opioids: motive and ubiquity issues. (J PAIN) Jun2008; 9 (6): 473-486. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pain and Pain Management. NLM UID: 100898657.
KW - Motivation
KW - Pain -- Psychosocial Factors
KW - Prescriptions, Drug -- Statistics and Numerical Data
KW - Surveys
KW - Pain -- Drug Therapy
SP - 487
EP - 489
JO - Journal of Pain
JF - Journal of Pain
JA - J PAIN
VL - 9
IS - 6
PB - Churchill Livingstone, Inc.
SN - 1526-5900
AD - Division of Population Surveys, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Maryland.
U2 - PMID: 18403270.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105810002&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105794043
T1 - Childhood overweight and obesity: is the gap closing the wrong way?
AU - Brunt H
AU - Lester N
AU - Davies G
AU - Williams R
Y1 - 2008/06//
N1 - Accession Number: 105794043. Language: English. Entry Date: 20080822. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 101188638.
KW - Pediatric Obesity
KW - Child
KW - Child, Preschool
KW - Chronic Disease
KW - Confidence Intervals
KW - Female
KW - Infant
KW - Linear Regression
KW - Male
KW - Public Health
KW - Socioeconomic Factors
KW - United Kingdom
KW - Human
SP - 145
EP - 152
JO - Journal of Public Health
JF - Journal of Public Health
JA - J PUBLIC HEALTH
VL - 30
IS - 2
PB - Oxford University Press / USA
SN - 1741-3842
AD - National Public Health Service for Wales, St. David's Park, Job's Well Road, Carmarthen SA31 3WY, UK. huw.brunt@nphs.wales.nhs.uk
U2 - PMID: 18310139.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lord, Alexandra M.
T1 - A Surgical Temptation: The Demonization of the Foreskin and the Rise of Circumcision in Britain.
JO - Journal of Social History
JF - Journal of Social History
Y1 - 2008///Summer2008
VL - 41
IS - 4
M3 - Book Review
SP - 1067
EP - 1069
PB - Oxford University Press / USA
SN - 00224529
AB - The article reviews the book "A Surgical Temptation: The Demonization of the Foreskin and the Rise of Circumcision in Britain," by Robert Darby.
KW - CIRCUMCISION
KW - NONFICTION
KW - DARBY, Robert
KW - SURGICAL Temptation: The Demonization of the Foreskin & the Rise of Circumcision in Britain, A (Book)
N1 - Accession Number: 32848248; Lord, Alexandra M. 1; Affiliation: 1: The United States Public Health Service; Source Info: Summer2008, Vol. 41 Issue 4, p1067; Subject Term: CIRCUMCISION; Subject Term: NONFICTION; Reviews & Products: SURGICAL Temptation: The Demonization of the Foreskin & the Rise of Circumcision in Britain, A (Book); People: DARBY, Robert; Number of Pages: 3p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Curns, Aaron T.
AU - Steiner, Claudia A.
AU - Sejvar, James J.
AU - Schonberger, Lawrence B.
T1 - Hospital Charges Attributable to a Primary Diagnosis of Infectious Diseases in Older Adults in the United States, 1998 to 2004.
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
Y1 - 2008/06//
VL - 56
IS - 6
M3 - Article
SP - 969
EP - 975
PB - Wiley-Blackwell
SN - 00028614
AB - OBJECTIVES: To describe total and average hospital charges associated with infectious disease (ID) hospitalizations and specific ID categories and to estimate ID hospitalization rates in adults aged 65 and older in the United States from 1998 through 2004. DESIGN: Retrospective analysis of hospital discharge data obtained from the Nationwide Inpatient Sample for 1998 through 2004. SETTING: United States. PATIENTS: Older adults hospitalized in the United States from 1998 through 2004. MEASUREMENTS: Hospital charges and hospitalization rates for IDs described according to year, age group, sex, U.S. Census region, and ID category. Charges for non-ID hospitalizations were also described. Hospital charges were adjusted for inflation. RESULTS: From 1998 through 2004, total charges for ID hospitalizations exceeded $261 billion and accounted for 13% of all hospital charges for older adults. Total charges for ID hospitalizations increased from $31.4 billion in 1998 to $45.7 billion in 2004. The average annual ID hospital charge was lower than the average annual non-ID hospital charge during the study period ($21,342 vs $22,787, P<.001). The average annual rate for ID hospitalizations was 503 per 10,000 older adults, which remained stable during the study period. CONCLUSION: The total charges for ID hospitalizations and for all hospitalizations in older adults in the United States increased 45% and nearly 40%, respectively, during the 7-year study period, whereas the population of older adults grew by only 5%. Sustained increases of such magnitude will have major implications for the U.S. healthcare system as it prepares for the more than doubling of the older U.S. adult population during the first 30 years of this century. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLDER people
KW - MEDICAL care for the aged
KW - OLDER people -- Hospital care
KW - OLDER people -- Health
KW - COMMUNICABLE diseases
KW - RESPIRATORY diseases in old age
KW - hospitalizations
KW - infectious disease
KW - lower respiratory tract infection
KW - older adults
N1 - Accession Number: 32470748; Curns, Aaron T. Steiner, Claudia A. 1 Sejvar, James J. 2 Schonberger, Lawrence B. 2; Affiliation: 1: Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland. 2: National Center for Zoonotic, Vector-Borne, and Enteric Diseases and; Source Info: Jun2008, Vol. 56 Issue 6, p969; Subject Term: OLDER people; Subject Term: MEDICAL care for the aged; Subject Term: OLDER people -- Hospital care; Subject Term: OLDER people -- Health; Subject Term: COMMUNICABLE diseases; Subject Term: RESPIRATORY diseases in old age; Author-Supplied Keyword: hospitalizations; Author-Supplied Keyword: infectious disease; Author-Supplied Keyword: lower respiratory tract infection; Author-Supplied Keyword: older adults; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1532-5415.2008.01712.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32470748&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105773511
T1 - Hospital charges attributable to a primary diagnosis of infectious diseases in older adults in the United States, 1998 to 2004.
AU - Curns AT
AU - Steiner CA
AU - Sejvar JJ
AU - Schonberger LB
Y1 - 2008/06//
N1 - Accession Number: 105773511. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Gerontologic Care. NLM UID: 7503062.
KW - Communicable Diseases -- Economics
KW - Health Care Costs -- Trends
KW - Health Facility Charges -- Trends
KW - Hospitalization -- Economics
KW - Aged
KW - Aged, 80 and Over
KW - Communicable Diseases -- Epidemiology
KW - Demography
KW - Female
KW - Health and Welfare Planning
KW - Hospitalization -- Statistics and Numerical Data
KW - Linear Regression
KW - Male
KW - Regression
KW - Retrospective Design
KW - Risk Factors
KW - United States
KW - Human
SP - 969
EP - 975
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
JA - J AM GERIATR SOC
VL - 56
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - OBJECTIVES: To describe total and average hospital charges associated with infectious disease (ID) hospitalizations and specific ID categories and to estimate ID hospitalization rates in adults aged 65 and older in the United States from 1998 through 2004. DESIGN: Retrospective analysis of hospital discharge data obtained from the Nationwide Inpatient Sample for 1998 through 2004. SETTING: United States. PATIENTS: Older adults hospitalized in the United States from 1998 through 2004. MEASUREMENTS: Hospital charges and hospitalization rates for IDs described according to year, age group, sex, U.S. Census region, and ID category. Charges for non-ID hospitalizations were also described. Hospital charges were adjusted for inflation. RESULTS: From 1998 through 2004, total charges for ID hospitalizations exceeded $261 billion and accounted for 13% of all hospital charges for older adults. Total charges for ID hospitalizations increased from $31.4 billion in 1998 to $45.7 billion in 2004. The average annual ID hospital charge was lower than the average annual non-ID hospital charge during the study period ($21,342 vs $22,787, P<.001). The average annual rate for ID hospitalizations was 503 per 10,000 older adults, which remained stable during the study period. CONCLUSION: The total charges for ID hospitalizations and for all hospitalizations in older adults in the United States increased 45% and nearly 40%, respectively, during the 7-year study period, whereas the population of older adults grew by only 5%. Sustained increases of such magnitude will have major implications for the U.S. healthcare system as it prepares for the more than doubling of the older U.S. adult population during the first 30 years of this century.
SN - 0002-8614
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 18410319.
DO - 10.1111/j.1532-5415.2008.01712.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - HUNTER, R. P.
AU - MAHMOOD, I.
AU - MARTINEZ, M. N.
T1 - Prediction of xenobiotic clearance in avian species using mammalian or avian data: how accurate is the prediction?
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2008/06//
VL - 31
IS - 3
M3 - Article
SP - 281
EP - 284
PB - Wiley-Blackwell
SN - 01407783
AB - The article examines whether allometric scaling can be or cannot be applied to birds through the use of data from other avian species or mammalian species to estimate the systemic clearance of xenobiotics. According to researchers, allometric scaling between mammalian and avian species produces highly biased estimates of drug clearance but it produced less error when the predictions are based solely upon data generated in other avian species
KW - ALLOMETRY
KW - BIRDS
KW - MAMMALS
KW - XENOBIOTICS
KW - STATISTICS
N1 - Accession Number: 31999330; HUNTER, R. P. 1; Email Address: hunter_robert_p@lilly.com MAHMOOD, I. 2 MARTINEZ, M. N. 3; Affiliation: 1: Elanco Animal Health, A Division of Eli Lilly and Company, Greenfield, IN, USA 2: Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 3: Division of Therapeutic Drugs for Food Animals (HFV-130), Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food & Drug Administration, Rockville, MD, USA; Source Info: Jun2008, Vol. 31 Issue 3, p281; Subject Term: ALLOMETRY; Subject Term: BIRDS; Subject Term: MAMMALS; Subject Term: XENOBIOTICS; Subject Term: STATISTICS; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 4p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1365-2885.2008.00956.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maximova, Olga A.
AU - Ward, Jerrold M.
AU - Asher, David M.
AU - St. Claire, Marisa
AU - Finneyfrock, Brad W.
AU - Speicher, James M.
AU - Murphy, Brian R.
AU - Pletnev, Alexander G.
T1 - Comparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman Primates.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008/06//
VL - 82
IS - 11
M3 - Article
SP - 5255
EP - 5268
SN - 0022538X
AB - Based on previous preclinical evaluation in mice and monkeys, the chimeric TBEV/DEN4{Delta}30 virus, carrying the prM and E protein genes from a highly virulent Far Eastern strain of tick-borne encephalitis virus (TBEV) on the backbone of a nonneuroinvasive dengue type 4 virus (DEN4), has been identified as a promising live attenuated virus vaccine candidate against disease caused by TBEV. However, prior to use of this vaccine candidate in humans, its neurovirulence in nonhuman primates needed to be evaluated. In the present study, we compared the neuropathogeneses of the chimeric TBEV/DEN4{Delta}30 virus; Langat virus (LGTV), a former live TBEV vaccine; and yellow fever 17D virus vaccine (YF 17D) in rhesus monkeys inoculated intracerebrally. TBEV/DEN4{Delta}30 and YF 17D demonstrated remarkably similar spatiotemporal profiles of virus replication and virus-associated histopathology in the central nervous system (CNS) that were high in cerebral hemispheres but progressively decreased toward the spinal cord. In contrast, the neurovirulence of LGTV exhibited the reverse profile, progressing from the site of inoculation toward the cerebellum and spinal cord. Analysis of the spatiotemporal distribution of viral antigens in the CNS of monkeys revealed a prominent neurotropism associated with all three attenuated viruses. Nevertheless, TBEV/DEN4{Delta}30 virus exhibited higher neurovirulence in monkeys than either LGTV or YF 17D, suggesting insufficient attenuation. These results provide insight into the neuropathogenesis associated with attenuated flaviviruses that may guide the design of safe vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NERVOUS system -- Diseases
KW - CHARCOT-Marie-Tooth disease
KW - VIRAL vaccines
KW - ANTIGENS
KW - TICK-borne diseases
KW - RHESUS monkey
N1 - Accession Number: 32525386; Maximova, Olga A. 1 Ward, Jerrold M. 2 Asher, David M. 1 St. Claire, Marisa 3 Finneyfrock, Brad W. 3 Speicher, James M. 4 Murphy, Brian R. 4 Pletnev, Alexander G. 4; Email Address: apletnev@niaid.nih.gov; Affiliation: 1: Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20852 2: Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3: Bioqual, Inc., Rockville, Maryland 208503 4: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892; Source Info: Jun2008, Vol. 82 Issue 11, p5255; Subject Term: NERVOUS system -- Diseases; Subject Term: CHARCOT-Marie-Tooth disease; Subject Term: VIRAL vaccines; Subject Term: ANTIGENS; Subject Term: TICK-borne diseases; Subject Term: RHESUS monkey; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1128/JVI.00172-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105787704
T1 - Increasing California children's Medicaid-financed mental health treatment by vigorously implementing Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program.
AU - Snowden LR
AU - Masland M
AU - Wallace N
AU - Fawley-King K
AU - Cuellar AE
Y1 - 2008/06//2008 Jun
N1 - Accession Number: 105787704. Language: English. Entry Date: 20080815. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care; Psychiatry/Psychology. Grant Information: Funded by the California HealthCare Foundation. NLM UID: 0230027.
KW - Health Services Accessibility -- Trends -- In Infancy and Childhood
KW - Medicaid
KW - Mental Health Services -- Trends -- California
KW - Psychiatric Care -- Trends -- In Infancy and Childhood
KW - California
KW - Child
KW - Descriptive Statistics
KW - Funding Source
KW - P-Value
KW - Regression
KW - Human
SP - 558
EP - 564
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 46
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Children living in poverty-especially children living in rural areas and in areas lacking a commitment to providing mental health care-have considerable unmet need for mental health treatment. Expansion of Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program might help to address this problem. OBJECTIVE: To evaluate whether a legally compelled expansion of mental health screening, treatment, and financing under EPSDT would translate into higher Medicaid penetration rates. Our particular focus was on changes in rural treatment systems and systems historically receiving low levels of state funding (ie, 'underequity' counties). METHODS: We used fixed-effects regression methods by observing 53 California county mental health plans over 36 quarters, yielding 1908 observations. Our models controlled for all static, county, and service system characteristics, and for ongoing linear trends in penetration rates. RESULTS: After controlling for previous trends, mental health treatment access increased following EPSDT mental health program expansion. The increase was greatest in rural systems, and counties that previously received less state funding which showed the greatest penetration rate increases. CONCLUSIONS: EPSDT mental health expansion and increased funding increased Medicaid-financed mental health treatment. The expansion efforts had the greatest effects in rural and underequity counties that faced the greatest barriers to mental health service use.
SN - 0025-7079
AD - School of Social Welfare and Center for Mental Health Services Research, University of California, Berkley, California
U2 - PMID: 18520309.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105787704&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Youngyih Han
AU - Eun Hyuk Shin
AU - Chunil Lim
AU - Se-Kwon Kang
AU - Sung Ho Park
AU - Jeong-Eun Lah
AU - Tae-suk Suh
AU - Myonggeun Yoon
AU - Se Byeong Lee
AU - Sang Hyun Cho
AU - Ibbott, Geoffrey S.
AU - Sang Gyu Ju
AU - Yong Chan Ahn
T1 - Dosimetry in an IMRT phantom designed for a remote monitoring program.
JO - Medical Physics
JF - Medical Physics
Y1 - 2008/06//
VL - 35
IS - 6
M3 - Article
SP - 2519
EP - 2527
SN - 00942405
AB - An accurate delivery of prescribed dose is essential to ensure the most successful outcome from advanced radiation treatments such as intensity modulated radiation therapy (IMRT). An anthropomorphic phantom was designed and constructed to conduct a remote-audit program for IMRT treatments. The accuracy of the dosimetry in the phantom was assessed by comparing the results obtained from different detectors with those from Monte Carlo calculations. The developed phantom has a shape of a cylinder with one target and three organs at risk (OARs) inside the unit. The target and OARs were shaped similar to those of nasopharyngeal cancer patients, and manufactured for their identification during computed tomography imaging. The phantom was designed with thermoluminescent dosimeter (TLD) holders that were inserted inside the target and the OARs for the measurements of absolute dose. In addition, the phantom allowed measurements with ionization chambers placed at the TLD locations. As a result, an inter-comparison between the two types of dosimeters was possible. For the measurement of the relative dose distribution across the target and OARs, two film slots were orthogonally placed near the center of the phantom, which also enabled the insertion of inhomogeneities near the target. Measurements with TLDs, provided by Korea Food and Drug Administration and Radiological Physics Center, and measurements with an ionization chamber (IC) were performed in four cases. The first case was one anterior field of 6 MV x rays delivered to the phantom; the second case used the same anterior field, but with inhomogeneities inserted into the phantom. The third case was three fields of 6 MV beams at an equi-gantry angle for the homogeneous phantom, and the fourth case was IMRT delivery to the phantom without inhomogeneities. For each case, measurements with both TLDs and IC were performed. For cases 1–3, theoretical predictions were obtained by using the Monte Carlo (MC) codes (BEAMnrc and DOSXYZnrc6.0). The TLD measurements were larger than the IC readings by 2.2% (1.3–2.5%), 2.2% (1.2–2.9%), and 2.1% (0–3.3%) on average for case 1, case 2 and case 3, respectively. The average deviation between TLDs and MC results was 0.97% (-0.13–2.07%) for the first case, 1.27% (0.34–2.18%) for the second case, and 1.13% (0.31–1.94%) for the third case. The IC reading was less than the MC results; the average deviations were -1.2% (-2.44–-0.43%), -0.96% (-1.74–-0.54%) and -0.94% (-1.53–0.27%) for the first, second, and third cases, respectively. For the IMRT case, the average deviation between IC readings and TLD measurements was 0.5% (-7.0–3.9%). In conclusion, the TLD measurements in the developed phantom agreed with IC and MC results with less than 3% of an average difference. The developed phantom with TLD dosimeters should be useful for remote monitoring of IMRT. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOTHERAPY
KW - MEDICAL physics
KW - MONTE Carlo method
KW - TOMOGRAPHY
KW - DOSIMETERS
KW - IMRT
KW - phantom
KW - quality assurance
KW - remote monitoring
N1 - Accession Number: 32566600; Youngyih Han 1; Email Address: youngyih@skku.edu Eun Hyuk Shin 1 Chunil Lim 2 Se-Kwon Kang 3 Sung Ho Park 4 Jeong-Eun Lah 5 Tae-suk Suh 5 Myonggeun Yoon 6 Se Byeong Lee 6 Sang Hyun Cho 7 Ibbott, Geoffrey S. 7 Sang Gyu Ju 1 Yong Chan Ahn 1; Affiliation: 1: Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea. 2: Korea Food and Drug Administration (KFDA), 194 Tongil-ro, Eunpyeong-gu, Seoul 122-704, Korea. 3: KangDong Sacred Heart Hospital, Hallym University, 445 Gil-Dong, KangDong-Gu, Seoul 134-701, Korea. 4: Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea. 5: Department of Biomedical Engineering, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. 6: Proton Therapy Center, National Cancer Center, 809 Madu 1-dong, Ilsandong-gu, Goyang, Gyeonggi-do 411-769, Korea. 7: University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009.; Source Info: Jun2008, Vol. 35 Issue 6, p2519; Subject Term: RADIOTHERAPY; Subject Term: MEDICAL physics; Subject Term: MONTE Carlo method; Subject Term: TOMOGRAPHY; Subject Term: DOSIMETERS; Author-Supplied Keyword: IMRT; Author-Supplied Keyword: phantom; Author-Supplied Keyword: quality assurance; Author-Supplied Keyword: remote monitoring; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 2 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1118/1.2903440
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32566600&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Logo, Fumiharu
AU - Watanabe, Eiji
AU - Park, Hyuntae
AU - Yasunaga, Akitomo
AU - Park, Sungjin
AU - Shephard, Roy J.
AU - Aoyagi, Yukitoshi
T1 - How Many Days of Pedometer Use Predict the Annual Activity of the Elderly Reliably?
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2008/06//
VL - 40
IS - 6
M3 - Article
SP - 1058
EP - 1064
SN - 01959131
AB - The article reports on the study of walking as an annual physical activity of elderly Japanese. The study aims to determine the differences and unevenness of step counts of elderly Japanese in a year through the use of accelerometer/pedometer. It is participated of 37 males and 44 females in Tokyo, Japan with ages ranging from 65-83 years old. It requires the elderly participants to wear the pedometer on their waistband throughout 1 year to collect information on the elderly's step count. It uses an electronic physical activity monitor which is consisted of uniaxial piezoresistive accelerometer and amplifier to measure accelerations of step counts and intensities of physical activity.
KW - OLDER people
KW - WALKING
KW - JAPANESE
KW - EXERCISE -- Research
KW - PEDOMETERS
KW - ACCELEROMETERS
KW - EXERCISE for older people
KW - TOKYO (Japan)
KW - JAPAN
KW - HABITUAL PHYSICAL ACTIVITY
KW - OUTCOME ASSESSMENT
KW - SAMPLING TECHNIQUES
KW - SEASONAL VARIATIONS
KW - STEP COUNT
N1 - Accession Number: 32196403; Logo, Fumiharu 1,2 Watanabe, Eiji 2 Park, Hyuntae 2 Yasunaga, Akitomo 2 Park, Sungjin 2 Shephard, Roy J. 3 Aoyagi, Yukitoshi 2; Email Address: aoyagi@trnig.or.jp; Affiliation: 1: Department of Work Stress Control, Japan National Institute of Occupational Safety and Health, Kanagawa, JAPAN 2: Exercise Sciences Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, JAPAN 3: Faculty of Physical Education and Health, University of Toronto, Ontario, CANADA; Source Info: Jun2008, Vol. 40 Issue 6, p1058; Subject Term: OLDER people; Subject Term: WALKING; Subject Term: JAPANESE; Subject Term: EXERCISE -- Research; Subject Term: PEDOMETERS; Subject Term: ACCELEROMETERS; Subject Term: EXERCISE for older people; Subject Term: TOKYO (Japan); Subject Term: JAPAN; Author-Supplied Keyword: HABITUAL PHYSICAL ACTIVITY; Author-Supplied Keyword: OUTCOME ASSESSMENT; Author-Supplied Keyword: SAMPLING TECHNIQUES; Author-Supplied Keyword: SEASONAL VARIATIONS; Author-Supplied Keyword: STEP COUNT; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; NAICS/Industry Codes: 334514 Totalizing Fluid Meter and Counting Device Manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1249/MSS.0b013e318167469a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32196403&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105806599
T1 - How many days of pedometer use predict the annual activity of the elderly reliably?
AU - Togo F
AU - Watanabe E
AU - Park H
AU - Yasunaga A
AU - Park S
AU - Shephard RJ
AU - Aoyagi Y
Y1 - 2008/06//
N1 - Accession Number: 105806599. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Gerontologic Care; Physical Therapy; Sports Medicine. Grant Information: Supported in part by: Japan Society for the Promotion of Science. NLM UID: 8005433.
KW - Accelerometry -- In Old Age
KW - Equipment Reliability
KW - Pedometers -- In Old Age
KW - Physical Activity -- Evaluation -- In Old Age
KW - Time Factors -- In Old Age
KW - Aged
KW - Aged, 80 and Over
KW - Analysis of Variance
KW - Body Weights and Measures -- In Old Age
KW - Convenience Sample
KW - Descriptive Statistics
KW - Evaluation Research
KW - Female
KW - Funding Source
KW - Gerontologic Care
KW - Intraclass Correlation Coefficient
KW - Japanese
KW - Male
KW - Mathematics
KW - Post Hoc Analysis
KW - Prospective Studies
KW - Repeated Measures
KW - Human
SP - 1058
EP - 1064
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
JA - MED SCI SPORTS EXERC
VL - 40
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Purpose: Daily variations of physical activity in the elderly remain unclear. We thus used a uniaxial accelerometer/pedometer to examine the variability of step counts for 1 yr, determining the minimum number of days observation needed to obtain reliable estimates of annual physical activity. Methods: Subjects were 37 males and 44 females, healthy Japanese, aged 65-83 yr. The pedometer was worn on the waistband throughout 1 yr, accumulating information on the individual's daily step count. Results: The step count spectrum showed peaks with periods of 2.3, 3.5, and 7.0 d and an aperiodic component that had a greater power at low frequencies (i.e., non-white noise). These characteristics were absent in randomly resequenced data. To ensure that 80% of total variance was attributable to between-subjects variance, 25 and 8 consecutive days of observation were needed in male and female subjects, respectively. To achieve 90% on this same measure of reliability, 105 and 37 consecutive days of observation were required. In contrast, 4 d of randomly timed observations yielded 80% reliability for both men and women, and 11 and 9 d gave 90% reliability in men and women, respectively. If sampling also took account of season and day of the week, the respective observation periods for men and women were reduced to 8 and 4 d (i.e., 2 and 1 consecutive days of sampling every 89 d) for 80% and to 16 and 12 d (i.e., 4 and 3 consecutive days every 89 d) for 90% reliability. Conclusion: When estimating annual step counts, seasonal and/or random sampling of data allows collection of reliable data during substantially fewer days than needed for consecutive observations.
SN - 0195-9131
AD - Dept of Work Stress Control, Japan National Institute of Occupational Safety and Health, Kanagawa, Japan
U2 - PMID: 18461001.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Guerrini, Marco
AU - Beccati, Daniela
AU - Shriver, Zachary
AU - Naggi, Annamaria
AU - Viswanathan, Karthik
AU - Bisio, Antonella
AU - Capila, Ishan
AU - Lansing, Jonathan C
AU - Guglieri, Sara
AU - Fraser, Blair
AU - Al-Hakim, Ali
AU - Gunay, Nur Sibel
AU - Zhang, Zhenqing
AU - Robinson, Luke
AU - Buhse, Lucinda
AU - Nasr, Moheb
AU - Woodcock, Janet
AU - Langer, Robert
AU - Venkataraman, Ganesh
AU - Linhardt, Robert J
T1 - Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2008/06//
VL - 26
IS - 6
M3 - Article
SP - 669
EP - 675
SN - 10870156
AB - Recently, certain lots of heparin have been associated with an acute, rapid onset of serious side effects indicative of an allergic-type reaction. To identify potential causes for this sudden rise in side effects, we examined lots of heparin that correlated with adverse events using orthogonal high-resolution analytical techniques. Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine. The disaccharide unit has an unusual sulfation pattern and is sulfated at the 2-O and 3-O positions of the glucuronic acid as well as at the 4-O and 6-O positions of the galactosamine. Given the nature of this contaminant, traditional screening tests cannot differentiate between affected and unaffected lots. Our analysis suggests effective screening methods that can be used to determine whether or not heparin lots contain the contaminant reported here. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polysaccharides
KW - Heparin
KW - Drug monitoring
KW - Disaccharides
KW - Glucuronic acid
KW - Anticoagulants (Medicine)
N1 - Accession Number: 32542421; Guerrini, Marco 1; Beccati, Daniela 2; Shriver, Zachary 3; Naggi, Annamaria 4; Viswanathan, Karthik 5; Bisio, Antonella 4; Capila, Ishan 6; Lansing, Jonathan C 6; Guglieri, Sara 4; Fraser, Blair 7; Al-Hakim, Ali 7; Gunay, Nur Sibel 6; Zhang, Zhenqing 8; Robinson, Luke 5; Buhse, Lucinda 7; Nasr, Moheb 7; Woodcock, Janet 7; Langer, Robert 9; Venkataraman, Ganesh 10; Linhardt, Robert J 8; Affiliations: 1: [1] Istituto di Ricerche Chimiche e Biochimiche “G. Ronzoni,” Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy. [2] These authors contributed equally to this work.; 2: [1] Momenta Pharmaceuticals, Inc., 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. [2] These authors contributed equally to this work.; 3: [1] Momenta Pharmaceuticals, Inc., 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. [2] Department of Biological Engineering, Harvard-MIT Division of Health Sciences & Technology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA. [3] These authors contributed equally to this work.; 4: Istituto di Ricerche Chimiche e Biochimiche “G. Ronzoni,” Città Studi, via Giuseppe, Colombo 81, 20133 Milan, Italy.; 5: Department of Biological Engineering, Harvard-MIT Division of Health Sciences & Technology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.; 6: Momenta Pharmaceuticals, Inc., 675 West Kendall Street, Cambridge, Massachusetts 02142, USA.; 7: Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993-0002, USA.; 8: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.; 9: [1] Department of Biological Engineering, Harvard-MIT Division of Health Sciences & Technology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA. [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.; 10: [1] Momenta Pharmaceuticals, Inc., 675 West Kendall Street, Cambridge, Massachusetts 02142, USA. [2] Department of Biological Engineering, Harvard-MIT Division of Health Sciences & Technology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.; Issue Info: Jun2008, Vol. 26 Issue 6, p669; Thesaurus Term: Polysaccharides; Subject Term: Heparin; Subject Term: Drug monitoring; Subject Term: Disaccharides; Subject Term: Glucuronic acid; Subject Term: Anticoagulants (Medicine); Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1038/nbt1407
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105763696
T1 - How human factors lead to medical device adverse events.
AU - Rich S
Y1 - 2008/06//
N1 - Accession Number: 105763696. Language: English. Entry Date: 20080711. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 7600137.
KW - Adverse Health Care Event
KW - Equipment Design
KW - Equipment Safety
KW - Product Selection Criteria
KW - Staff Development
SP - 62
EP - 63
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Senior project manager of the patient-safety staff at the Office of Surveillance and Biometrics, Center for Devices and Radiological Health at the Food and Drug Administration in Rockville, Md.
U2 - PMID: 18497666.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Interpreting the Evidence: Helping Consumers Understand Medical Information.
JO - Nursing for Women's Health
JF - Nursing for Women's Health
Y1 - 2008/06//Jun/Jul2008
VL - 12
IS - 3
M3 - Article
SP - 200
EP - 202
SN - 17514851
AB - The article discusses the efficiency of clinical caregivers' education and training and offers practical tips for patients to understand medical information well. Most consumers assume that the treatments prescribed are based on the scientific evidence. In this context, three steps toward translating evidence for consumers are provided, such as to synthesize published and unpublished scientific evidence, generate analytic tools and translate findings into a variety of useful formats.
KW - PATIENT education
KW - HEALTH education
KW - HEALTH promotion
KW - MEDICAL informatics
KW - MEDICAL care
KW - INFORMATION science
KW - MEDICAL records
N1 - Accession Number: 32485252; Clancy, Carolyn M. 1; Source Information: Jun/Jul2008, Vol. 12 Issue 3, p200; Subject: PATIENT education; Subject: HEALTH education; Subject: HEALTH promotion; Subject: MEDICAL informatics; Subject: MEDICAL care; Subject: INFORMATION science; Subject: MEDICAL records; Number of Pages: 3p; Illustrations: 1 Color Photograph; Document Type: Article
L3 - 10.1111/j.1751-486X.2008.00322.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105802849
T1 - Interpreting the evidence: helping consumers understand medical information.
AU - Clancy CM
Y1 - 2008/06//Jun/Jul2008
N1 - Accession Number: 105802849. Language: English. Entry Date: 20080829. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Obstetric Care; Women's Health. NLM UID: 101304602.
KW - Decision Making, Patient
KW - Patient Education
KW - Research -- Education
KW - Information Resources
KW - Nurse-Patient Relations
KW - Quality of Health Care
KW - World Wide Web
SP - 200
EP - 202
JO - Nursing for Women's Health
JF - Nursing for Women's Health
JA - NURS WOMENS HEALTH
VL - 12
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1751-4851
AD - Agency for Healthcare Research and Quality in Rockville, MD, USA.
U2 - PMID: 18557848.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schubauer-Berigan, M. K.
AU - Deddens, J. A.
AU - Steenland, K.
AU - Sanderson, W. T.
AU - Petersen, M. R.
T1 - Adjustment for temporal confounders in a reanalysis of a case—control study of beryllium and lung cancer.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2008/06//
VL - 65
IS - 6
M3 - Article
SP - 379
EP - 383
SN - 13510711
AB - Objectives: To evaluate potential confounding of the association between beryllium and lung cancer in a reanalysis of data from a published case-control study of workers at a beryllium processing facility. Methods: The association of cumulative and average beryllium exposure with lung cancer among 142 cases and five age-match controls per case was reanalysed using conditional logistic regression. Adjustment was made independently for potential confounders of hire age and birth year. Alternative adjustments to avoid taking the logarithm of zero were explored. Results: Adjustment for either birth cohort or hire age (two highly correlated factors( attenuated lung cancer risk associated with cumulative exposure; however, lung cancer risk was significantly associated with average exposure using a 10-year lag following adjustment. Stratification of analyses by birth cohort found greater lung cancer risk from cumulative and average exposure for workers born before 1900 than for workers born later. The magnitude of the association between lung cancer and average exposure was not reduced by modifying the method used to take the log of exposure. Conclusion: In this reanalysis, average, but not cumulative, beryllium exposure was related to lung cancer risk after adjustment for birth cohort. Confounding by birth cohort is likely related to differences in smoking patterns for workers born before 1900 and the tendency for workers hired during the World War II era to have been older at hire. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Occupational diseases
KW - Health risk assessment
KW - Industrial hygiene
KW - Chemical industry
KW - Lungs -- Cancer -- Risk factors
KW - Beryllium industry
KW - Cohort analysis
KW - Nonferrous metal industries
KW - Occupational medicine
N1 - Accession Number: 32539482; Schubauer-Berigan, M. K. 1; Email Address: zcg3@cdc.gov; Deddens, J. A. 1; Steenland, K. 2; Sanderson, W. T. 3; Petersen, M. R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA; 2: Emory University School of Public Health, Atlanta, Georgia, USA; 3: University of Iowa School of Public Health, Iowa City, Iowa, USA; Issue Info: Jun2008, Vol. 65 Issue 6, p379; Thesaurus Term: DISEASES; Thesaurus Term: Occupational diseases; Thesaurus Term: Health risk assessment; Thesaurus Term: Industrial hygiene; Thesaurus Term: Chemical industry; Subject Term: Lungs -- Cancer -- Risk factors; Subject Term: Beryllium industry; Subject Term: Cohort analysis; Subject Term: Nonferrous metal industries; Subject Term: Occupational medicine; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 331490 Non-ferrous metal (except copper and aluminum) rolling, drawing, extruding and alloying; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1136/oem.2007.033654
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32539482&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kyler, Panelpha L.
T1 - Client-Centered and Family-Centered Care: Refinement of the Concepts.
JO - Occupational Therapy in Mental Health
JF - Occupational Therapy in Mental Health
Y1 - 2008/06//
VL - 24
IS - 2
M3 - Article
SP - 100
EP - 120
SN - 0164212X
AB - Occupational therapy has emphasized the relationship between the therapist and the client. The occupational therapy guidelines for client-centered practice produced in the 1980s by the Canadian Department of National Health and Welfare and the Canadian Association of Occupational Therapists (Task Force on Guidelines for the Practice of Occupational Therapy, 1983) has had variable use over the years. While occupational therapists believe in the principles of client-centered care, the philosophical concepts have been difficult to fully implement and also seem narrow in light of all the external forces and challenges posed by today's clients and their rights, and the ethics of medicine. Other concepts need to be in place to facilitate the true constructs of client-centered care. A historical overview of the medical perspective and the occupational therapy perspectives on client-centered and family-centered care are reviewed. Lessons learned from the various iterations of client-centered and family-centered care are posed for consideration of a newer more inclusive relationship-centered concept for occupational therapy. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational Therapy in Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OCCUPATIONAL therapy
KW - CLIENT-centered psychotherapy
KW - FAMILY nursing
KW - OCCUPATIONAL therapists
KW - MEDICAL ethics
KW - THERAPEUTICS
KW - Client-centered care
KW - family-centered care
KW - occupational therapy
KW - relationship centered care
N1 - Accession Number: 33141804; Kyler, Panelpha L. 1; Email Address: pkyler@comcast.net; Affiliation: 1: Department of Health and Human Services, Genetic Services Branch, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD; Source Info: 2008, Vol. 24 Issue 2, p100; Subject Term: OCCUPATIONAL therapy; Subject Term: CLIENT-centered psychotherapy; Subject Term: FAMILY nursing; Subject Term: OCCUPATIONAL therapists; Subject Term: MEDICAL ethics; Subject Term: THERAPEUTICS; Author-Supplied Keyword: Client-centered care; Author-Supplied Keyword: family-centered care; Author-Supplied Keyword: occupational therapy; Author-Supplied Keyword: relationship centered care; NAICS/Industry Codes: 621340 Offices of Physical, Occupational and Speech Therapists, and Audiologists; Number of Pages: 21p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1080/01642120802055150
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33141804&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105657040
T1 - Client-centered and family-centered care: refinement of the concepts.
AU - Kyler PL
Y1 - 2008/06//
N1 - Accession Number: 105657040. Language: English. Entry Date: 20081003. Revision Date: 20150819. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Special Interest: Occupational Therapy. NLM UID: 8010971.
KW - Family Centered Care
KW - Occupational Therapy Practice
KW - Patient Centered Care
KW - Professional-Patient Relations
KW - Conceptual Framework
KW - Family Centered Care -- Ethical Issues
KW - Patient Centered Care -- Ethical Issues
SP - 100
EP - 120
JO - Occupational Therapy in Mental Health
JF - Occupational Therapy in Mental Health
JA - OCCUP THER MENT HEALTH
VL - 24
IS - 2
PB - Taylor & Francis Ltd
AB - Occupational therapy has emphasized the relationship between the therapist and the client. The occupational therapy guidelines for client-centered practice produced in the 1980s by the Canadian Department of National Health and Welfare and the Canadian Association of Occupational Therapists (Task Force on Guidelines for the Practice of Occupational Therapy, 1983) has had variable use over the years. While occupational therapists believe in the principles of client-centered care, the philosophical concepts have been difficult to fully implement and also seem narrow in light of all the external forces and challenges posed by today's clients and their rights, and the ethics of medicine. Other concepts need to be in place to facilitate the true constructs of client-centered care. A historical overview of the medical perspective and the occupational therapy perspectives on client-centered and family-centered care are reviewed. Lessons learned from the various iterations of client-centered and family-centered care are posed for consideration of a newer more inclusive relationship-centered concept for occupational therapy.
SN - 0164-212X
AD - Department of Health and Human Services, Genetic Services Branch, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD; pkyler@comcast.net
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Susanna-Assunta Sansone
AU - Philippe Rocca-Serra
AU - Marco Brandizi
AU - Alvis Brazma
AU - Dawn Field
AU - Jennifer Fostel
AU - Andrew G. Garrow
AU - Jack Gilbert
AU - Federico Goodsaid
AU - Nigel Hardy
AU - Phil Jones
AU - Allyson Lister
AU - Michael Miller
AU - Norman Morrison
AU - Tim Rayner
AU - Nataliya Sklyar
AU - Chris Taylor
AU - Weida Tong
AU - Guy Warner
AU - Stefan Wiemann
T1 - The First RSBI (ISA-TAB) Workshop: “Can a Simple Format Work for Complex Studies?”.
JO - OMICS: A Journal of Integrative Biology
JF - OMICS: A Journal of Integrative Biology
Y1 - 2008/06//
VL - 12
IS - 2
M3 - Article
SP - 143
EP - 149
SN - 15362310
AB - AbstractThis article summarizes the motivation for, and the proceedings of, the first ISA-TAB workshop held December 6–8, 2007, at the EBI, Cambridge, UK. This exploratory workshop, organized by members of the Microarray Gene Expression Data (MGED) Society's Reporting Structure for Biological Investigations (RSBI) working group, brought together a group of developers of a range of collaborative systems to discuss the use of a common format to address the pressing need of reporting and communicating data and metadata from biological, biomedical, and environmental studies employing combinations of genomics, transcriptomics, proteomics, and metabolomics technologies along with more conventional methodologies. The expertise of the participants comprised database development, data management, and hands-on experience in the development of data communication standards. The workshop's outcomes are set to help formalize the proposed Investigation, Study, Assay (ISA)-TAB tab-delimited format for representing and communicating experimental metadata. This article is part of the special issue of OMICS on the activities of the Genomics Standards Consortium (GSC). [ABSTRACT FROM AUTHOR]
AB - Copyright of OMICS: A Journal of Integrative Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR genetics
KW - GENE expression
KW - GENETIC regulation
KW - GENOMES
N1 - Accession Number: 33051435; Susanna-Assunta Sansone 1 Philippe Rocca-Serra 1 Marco Brandizi 1 Alvis Brazma 1 Dawn Field 2 Jennifer Fostel 3 Andrew G. Garrow 4 Jack Gilbert 5 Federico Goodsaid 6 Nigel Hardy 7 Phil Jones 1 Allyson Lister 8 Michael Miller 9 Norman Morrison 2,10 Tim Rayner 1 Nataliya Sklyar 1 Chris Taylor 1 Weida Tong 11 Guy Warner 4 Stefan Wiemann 12; Affiliation: 1: EMBL-EBI The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom. 2: NERC Centre for Ecology and Hydrology, Mansfield Rd, Oxford, United Kingdom. 3: NIH, National Institute of Environmental Health Science (NIEHS), Research Triangle Park, North Carolina. 4: Unilever, Safety and Environmental Assurance Centre, Colworth Park, Sharnbrook, Bedford, United Kingdom. 5: Plymouth Marine Laboratory, Prospect Place, Plymouth, United Kingdom. 6: Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research (CDER) U.S. Food and Drug Administration (FDA), Silver Spring, Maryland. 7: Department of Computer Science, Aberystwyth University, Ceredigion, Wales, United Kingdom. 8: CISBAN & School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom. 9: Rosetta Biosoftware, Seattle, Washington. 10: NERC Bioinformatics Center (NEBC), Centre for Ecology and Hydrology, Oxford, United Kingdom, and the University of Manchester, School of Computer Science, Manchester, United Kingdom. 11: FDA's National Center for Toxicological Research (NCTR), Center for Toxicoinformatics, Jefferson, Arkansas. 12: German Cancer Research Center, Heidelberg, Germany.; Source Info: Jun2008, Vol. 12 Issue 2, p143; Subject Term: MOLECULAR genetics; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: GENOMES; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105682807
T1 - FDA drug approval summary: nelarabine (ARRANON) for the treatment of T-cell lymphoblastic leukemia/lymphoma.
AU - Cohen MH
AU - Johnson JR
AU - Justice R
AU - Pazdur R
Y1 - 2008/06//
N1 - Accession Number: 105682807. Language: English. Entry Date: 20081107. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents -- Therapeutic Use
KW - Leukemia, Lymphocytic, Acute -- Drug Therapy
KW - Lymphoma -- Drug Therapy
KW - Adult
KW - Antineoplastic Agents -- Adverse Effects
KW - Child
KW - Clinical Trials
KW - Confidence Intervals
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Neurologic Manifestations
KW - Treatment Outcomes
KW - Human
SP - 709
EP - 714
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 6
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Purpose. To describe the clinical trials leading to U.S. Food and Drug Administration (FDA) approval of nelarabine (Arranon\'01), a new purine analogue, for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. Experimental Design. Two phase II trials, one conducted in pediatric patients and the other in adult patients, were reviewed. Patients were in their first or subsequent relapse and/or were refractory to first-line therapy. The dose and schedule of i.v. nelarabine in the pediatric and adult studies were 650 mg/m2 per day daily for 5 days and 1,500 mg/m2 i.v. on days 1, 3, and 5, respectively. Treatments were repeated every 21 days. Study endpoints were the rates of complete response (CR) and CR with incomplete hematologic or bone marrow recovery (CR*). Results. The pediatric efficacy population consisted of 39 patients who had relapsed after, or had been refractory to, two or more induction regimens. CR to nelarabine treatment was observed in five patients (13%) and CR\'01CR* was observed in nine patients (23%). The adult efficacy population consisted of 28 patients. CR to nelarabine treatment was observed in five patients (18%) and CR\'01CR* was observed in six patients (21%). Neurologic toxicity was dose limiting for both pediatric and adult patients. Other severe toxicities included hematologic, hepatic, and metabolic laboratory abnormalities in pediatric patients and gastrointestinal and pulmonary toxicities in adults. Conclusions. On October 28, 2005, the FDA granted accelerated approval for nelarabine for treatment of patients with relapsed or refractory T-ALL/T-LBL after at least two prior regimens. This use is based on the induction of CR. The applicant will conduct postmarketing clinical trials to demonstrate clinical benefit, for example, survival prolongation.
SN - 1083-7159
AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA
U2 - PMID: 18586926.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105682807&site=ehost-live&scope=site
UR - Related websites: CME.TheOncologist.com
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Beger, Richard D.
AU - Holland, Ricky D.
AU - Sun, Jinchun
AU - Schnackenberg, Laura K.
AU - Moore, Page C.
AU - Dent, Catherine L.
AU - Devarajan, Prasad
AU - Portilla, Didier
T1 - Metabonomics of acute kidney injury in children after cardiac surgery.
JO - Pediatric Nephrology
JF - Pediatric Nephrology
Y1 - 2008/06//
VL - 23
IS - 6
M3 - Article
SP - 977
EP - 984
PB - Springer Science & Business Media B.V.
SN - 0931041X
AB - Acute kidney injury (AKI) is a major complication in children who undergo cardiopulmonary bypass surgery. We performed metabonomic analyses of urine samples obtained from 40 children that underwent cardiac surgery for correction of congenital cardiac defects. Serial urine samples were obtained from each patient prior to surgery and at 4 h and 12 h after surgery. AKI, defined as a 50% or greater rise in baseline level of serum creatinine, was noted in 21 children at 48–72 h after cardiac surgery. The principal component analysis of liquid chromatography/mass spectrometry (LC/MS) negative ionization data of the urine samples obtained 4 h and 12 h after surgery from patients who develop AKI clustered away from patients who did not develop AKI. The LC/MS peak with mass-to-charge ratio (m/z) 261.01 and retention time (tR) 4.92 min was further analyzed by tandem mass spectrometry (MS/MS) and identified as homovanillic acid sulfate (HVA-SO4), a dopamine metabolite. By MS single-reaction monitoring, the sensitivity was 0.90 and specificity was 0.95 for a cut-off value of 24 ng/μl for HVA-SO4 at 12 h after surgery. We concluded that urinary HVA-SO4 represents a novel, sensitive, and predictive early biomarker of AKI after pediatric cardiac surgery. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatric Nephrology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACUTE kidney failure in children
KW - CARDIOPULMONARY bypass
KW - CONGENITAL heart disease
KW - CHROMATOGRAPHIC analysis
KW - MASS spectrometry
KW - CARDIAC surgery
KW - Acute kidney injury
KW - Acute renal failure
KW - Biomarkers
KW - Homovanillic acid sulfate
KW - Metabonomics
N1 - Accession Number: 31771483; Beger, Richard D. 1; Email Address: Richard.Beger@fda.hhs.gov Holland, Ricky D. 1 Sun, Jinchun 1 Schnackenberg, Laura K. 1 Moore, Page C. 2 Dent, Catherine L. 3 Devarajan, Prasad 4 Portilla, Didier 5; Affiliation: 1: Division of Systems Toxicology, United States Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA 3: Cardiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA 4: Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA 5: Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA; Source Info: Jun2008, Vol. 23 Issue 6, p977; Subject Term: ACUTE kidney failure in children; Subject Term: CARDIOPULMONARY bypass; Subject Term: CONGENITAL heart disease; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: MASS spectrometry; Subject Term: CARDIAC surgery; Author-Supplied Keyword: Acute kidney injury; Author-Supplied Keyword: Acute renal failure; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Homovanillic acid sulfate; Author-Supplied Keyword: Metabonomics; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1007/s00467-008-0756-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105586295
T1 - Metabonomics of acute kidney injury in children after cardiac surgery.
AU - Beger RD
AU - Holland RD
AU - Sun J
AU - Schnackenberg LK
AU - Moore PC
AU - Dent CL
AU - Devarajan P
AU - Portilla D
Y1 - 2008/06//
N1 - Accession Number: 105586295. Language: English. Entry Date: 20090220. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Special Interest: Pediatric Care. Grant Information: Supported in part by an interagency agreement between the US Department of Energy and the US Food and Drug Administration, and supported by NIH and a VA Merit and REAP Award, and the NIH/National Institute of Diabetes and Digestive and Kidney Diseases. NLM UID: 8708728.
KW - Acids, Carbocyclic -- Urine -- In Infancy and Childhood
KW - Cardiopulmonary Bypass -- Adverse Effects
KW - Heart Defects, Congenital -- Surgery
KW - Heart Surgery -- Adverse Effects
KW - Kidney Diseases -- Metabolism -- In Infancy and Childhood
KW - Kidney -- Metabolism -- In Infancy and Childhood
KW - Sulfates -- Urine -- In Infancy and Childhood
KW - Acute Disease
KW - Biological Markers -- Urine
KW - Child, Preschool
KW - Chromatography, Liquid
KW - Creatinine -- Blood
KW - Data Analysis Software
KW - Factor Analysis
KW - Female
KW - Funding Source
KW - Kidney Diseases -- Diagnosis
KW - Kidney Diseases -- Etiology
KW - Male
KW - Ohio
KW - Predictive Value of Tests
KW - Prospective Studies
KW - Reproducibility of Results
KW - ROC Curve
KW - Sensitivity and Specificity
KW - Mass Spectrometry
KW - Time Factors
KW - Human
SP - 977
EP - 984
JO - Pediatric Nephrology
JF - Pediatric Nephrology
JA - PEDIATR NEPHROL
VL - 23
IS - 6
CY - ,
PB - Springer Science & Business Media B.V.
SN - 0931-041X
AD - Division of Systems Toxicology, United States Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Richard.Beger@fda.hhs.gov
U2 - PMID: 18320237.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105586295&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Haber, Penina
AU - Patel, Manish
AU - Izurieta, Hector S.
AU - Baggs, James
AU - Gargiullo, Paul
AU - Weintraub, Eric
AU - Cortese, Margaret
AU - Braun, M. Miles
AU - Belongia, Edward A.
AU - Miller, Elaine
AU - Ball, Robert
AU - Iskander, John
AU - Parashar, Umesh D.
T1 - Postlicensure Monitoring of Intussusception After RotaTeq Vaccination in the United States, February 1, 2006, to September 25, 2007.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/06//
VL - 121
IS - 6
M3 - Article
SP - 1206
EP - 1212
SN - 00314005
AB - BACKGROUND. In 1999, a previous rotavirus vaccine (RotaShield; Wyeth Laboratories, [ Marietta, PA) was withdrawn from the US market after postlicensure monitoring identified an association with intussusception. Although the new rotavirus vaccine (RotaTeq; Merck, West Point, PA) introduced in 2006 was not associated with intussusception in prelicensure trials, additional monitoring is important to ensure a complete safety profile. METHODS. We assessed intussusception reports after RotaTeq vaccination by using data from the Vaccine Adverse Event Reporting System and the Vaccine Safety Datalink, a cohort of children enrolled in managed care. Observed versus expected rate ratios were determined by using vaccine dose distribution data and Vaccine Safety Datalink background intussusception rates. RESULTS. Between February 1, 2006, and September 25, 2007, the Vaccine Adverse Event Reporting System received 160 intussusception reports after RotaTeq vaccination. With the assumptions that reporting completeness was 75% and that 75% of the distributed doses of RotaTeq were administered, the observed versus expected rate ratios were 0.53 and 0.91 for the 1-21 and 1-7 day interval after vaccination, respectively. In the Vaccine Safety Datalink, 3 intussusception cases occurred within 30 days after 111 521 RotaTeq vaccinations, compared with 6 cases after 186 722 non-RotaTeq vaccinations during the same period. If, like RotaShield, RotaTeq had a 37-fold increased risk of intussusception within 3 to 7 days after vaccination, then 8 intussusception cases would be expected within 3 to 7 days among the -84 000 infants vaccinated with the first dose of RotaTeq in the Vaccine Safety Datalink (N = 49 902) and the prelicensure trial (N = 34 035) combined, whereas no cases have been observed. CONCLUSIONS. Available data do not indicate that RotaTeq is associated with intussusception. Although an intussusception risk similar in magnitude to that of RotaShield can be excluded, continued monitoring is necessary for complete assessment of the safety profile of RotaTeq. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTUSSUSCEPTION in children
KW - INTESTINAL intussusception
KW - VACCINATION
KW - ROTAVIRUSES
KW - PREVENTIVE medicine
KW - IMMUNIZATION of children
KW - COMMUNICABLE diseases -- Prevention
KW - MEDICAL care -- United States
KW - UNITED States
KW - adverse event
KW - intussusception
KW - rotavirus vaccine
KW - vaccine safety
N1 - Accession Number: 32616429; Haber, Penina 1 Patel, Manish 2; Email Address: aul3@cdc.gov Izurieta, Hector S. 3 Baggs, James 1 Gargiullo, Paul 1 Weintraub, Eric 1 Cortese, Margaret 2 Braun, M. Miles 3 Belongia, Edward A. 4 Miller, Elaine 1 Ball, Robert 3 Iskander, John 1 Parashar, Umesh D. 2; Affiliation: 1: Immunization Safety Office, Office of the Chief Science Officer 2: National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 4: Marshfield Clinic Research Foundation, Epidemiology Research Center, Marshfield, Wisconsin; Source Info: Jun2008, Vol. 121 Issue 6, p1206; Subject Term: INTUSSUSCEPTION in children; Subject Term: INTESTINAL intussusception; Subject Term: VACCINATION; Subject Term: ROTAVIRUSES; Subject Term: PREVENTIVE medicine; Subject Term: IMMUNIZATION of children; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; Author-Supplied Keyword: adverse event; Author-Supplied Keyword: intussusception; Author-Supplied Keyword: rotavirus vaccine; Author-Supplied Keyword: vaccine safety; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1542/peds.2007-3793
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun Woo
T1 - Isoliquiritigenin Inhibits Cell Proliferation by a Heme Oxygenase-Dependent Pathway in Rat Hepatic Stellate Cells.
JO - Planta Medica
JF - Planta Medica
Y1 - 2008/06//
VL - 74
IS - 8
M3 - Article
SP - 834
EP - 839
SN - 00320943
AB - We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression. ISL significantly inhibited serum- or growth factor-induced HSC proliferation. The inhibition of platelet-derived growth factor (PDGF)-induced proliferation by ISL was associated with the mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-p70 S6Kpathways. ISL induced the expression of HO-1 in HSCs. Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1. These data suggest that HO-1 expression is responsible for the antiproliferative effect of ISL on HSCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Planta Medica is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - HEME oxygenase
KW - KUPFFER cells
KW - PLATELET-derived growth factor
N1 - Accession Number: 33181604; Sun Woo 1; Affiliation: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea; Source Info: Jun2008, Vol. 74 Issue 8, p834; Subject Term: CELL proliferation; Subject Term: HEME oxygenase; Subject Term: KUPFFER cells; Subject Term: PLATELET-derived growth factor; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33181604&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105702585
T1 - Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells.
AU - Woo SW
AU - Lee SH
AU - Ko G
AU - Kim YC
AU - Sohn DH
Y1 - 2008/06//
N1 - Accession Number: 105702585. Language: English. Entry Date: 20081128. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Alternative/Complementary Therapies; Biomedical; Continental Europe; Europe; Peer Reviewed. NLM UID: 0066751.
KW - Cell Physiology -- Drug Effects
KW - Flavonoids -- Pharmacodynamics
KW - Oxidoreductases -- Metabolism
KW - Plants
KW - Platelet-Derived Growth Factor -- Metabolism
KW - Animals
KW - Cells
KW - Flavonoids
KW - Liver
KW - Rats
SP - 834
EP - 839
JO - Planta Medica
JF - Planta Medica
JA - PLANTA MEDICA
VL - 74
IS - 8
PB - Georg Thieme Verlag Stuttgart
SN - 0032-0943
AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea.
U2 - PMID: 18563666.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105702585&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Saviola, James
T1 - Looking for a Change.
JO - Review of Cornea & Contact Lenses
JF - Review of Cornea & Contact Lenses
Y1 - 2008/06//
M3 - Editorial
SP - 6
EP - 7
AB - The author argues that ophthalmologists need to make informed recommendations to their contact lens patients. He cites the challenge faced by ophthalmologists with the contact lens care products as they are sold over-the-counter and marketed based on their convenience or cost. He asserts the importance of being diligent in evaluating lens care products' effects on patient's ocular surface to avoid the possible consequences of corneal staining.
KW - OPHTHALMOLOGISTS
KW - CONTACT lenses
KW - EYE -- Care & hygiene
KW - OPTOMETRY
N1 - Accession Number: 33220656; Saviola, James 1,2; Affiliations: 1: Chief, Vitreoretinal and Extraocular Devices Branch, Food and Drug Administration's Office of Device Evaluation; 2: Ophthalmic and Ear, Nose mid Throat Network Leader, FDA's Center for Devices and Radiological Health; Issue Info: Jun2008, p6; Subject Term: OPHTHALMOLOGISTS; Subject Term: CONTACT lenses; Subject Term: EYE -- Care & hygiene; Subject Term: OPTOMETRY; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 423460 Ophthalmic Goods Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 2p; Document Type: Editorial
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DP - EBSCOhost
DB - buh
ER -
TY - NEWS
AU - Truman, Richard
T1 - Armadillos as a Source of Infection for Leprosy.
JO - Southern Medical Journal
JF - Southern Medical Journal
Y1 - 2008/06//
VL - 101
IS - 6
M3 - Editorial
SP - 581
EP - 582
SN - 15418243
AB - The article discusses the zoonotic transmission of leprosy between humans and armadillos. It reveals that leprosy remains a very rare disease in the United States and that many people are exposed to armadillos without ever acquiring the infection. The article discusses the need for physicians working in the southern states to be award that leprosy continues to exist in the U.S.
KW - LEPROSY
KW - ARMADILLOS
KW - ANIMALS as carriers of disease
KW - ZOONOSES
KW - UNITED States
N1 - Accession Number: 32669017; Truman, Richard 1; Email Address: rtruman@hrsa.gov; Affiliation: 1: United States Department of Health and Human Services; Health Resources and Services Administration, Bureau of Primary Health Care, National Hansen's Disease Program, Baton Rouge, LA.; Source Info: Jun2008, Vol. 101 Issue 6, p581; Subject Term: LEPROSY; Subject Term: ARMADILLOS; Subject Term: ANIMALS as carriers of disease; Subject Term: ZOONOSES; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Editorial
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32669017&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ramadevi Raghunandan
AU - Maria Ruiz-Hidalgo
AU - Yifeng Jia
AU - Rachael Ettinger
AU - Eva Rudikoff
AU - Patrick Riggins
AU - Richard Farnsworth
AU - Abeba Tesfaye
AU - Jorge Laborda
AU - Steven R. Bauer
T1 - Dlk1Influences Differentiation and Function of B Lymphocytes.
JO - Stem Cells & Development
JF - Stem Cells & Development
Y1 - 2008/06//
VL - 17
IS - 3
M3 - Article
SP - 495
EP - 508
SN - 15473287
AB - The Dlk1(delta-like-1) gene is a member of the epidermal growth factor (EGF)-like homeotic gene family. It influences cell–cell interactions between stromal cells and pro-B cells in vitro. To define the in vivo role of the dlk protein in B cell development, we established a Dlk1−sol;−mouse model. In spleens of Dlk1−sol;−mice, transitional B cell numbers were increased and the ratio between transitional B cell subsets was altered. Numbers of follicular B cells decreased, while the number of marginal zone B cells and the size of the marginal zone were increased. Loss of dlk resulted in increased immunoglobulin G1 (IgG1) and IgG3in preimmune sera. Furthermore, there was an exaggerated primary T-dependent antigen-specific humoral immune response. In bone marrow, the lack of dlk led to increased numbers of the earliest B lineage cells in young mice without affecting numbers of later B lineage cells. In vitro experiments showed that lack of dlk on either stromal cells or pro-B cells caused changes in differentiation and proliferation of pro-B cells, suggesting that lack of dlk leads to changes in cell–cell interactions in the bone marrow microenvironment. These results show that dlk expression is essential for normal B cell development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Stem Cells & Development is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNE system
KW - LYMPHOCYTES
KW - B cells
KW - FC receptors
N1 - Accession Number: 33051599; Ramadevi Raghunandan 1,2 Maria Ruiz-Hidalgo 3 Yifeng Jia 1 Rachael Ettinger 4 Eva Rudikoff 1 Patrick Riggins 1 Richard Farnsworth 1,5 Abeba Tesfaye 1 Jorge Laborda 3 Steven R. Bauer 1; Affiliation: 1: Cellular and Tissue Therapies Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration. Bethesda, MD, 20892. 2: CytImmune, Inc., 9640 Medical Center Drive, Rockville, MD 20850. 3: Biochemistry and Molecular Biology Branch, Medical SchoolRegional Center for Biomedical Investigations (CRIB), University of Castilla-La Mancha. Albacete, Spain. 4: Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health. Bethesda, MD, 20892. 5: Battelle Memorial Institute, 1000 Research Park Blvd., Charlottesville, VA 22911.; Source Info: Jun2008, Vol. 17 Issue 3, p495; Subject Term: IMMUNE system; Subject Term: LYMPHOCYTES; Subject Term: B cells; Subject Term: FC receptors; Number of Pages: 14p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33051599&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-08538-001
AN - 2008-08538-001
AU - Manderscheid, Ron
AU - Delvecchio, Paolo
T1 - Guest editor's introduction: Moving toward solutions: Responses to the crisis of premature death.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2008///Sum 2008
VL - 37
IS - 2
SP - 3
EP - 7
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2008-08538-001. Partial author list: First Author & Affiliation: Manderscheid, Ron; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, US. Other Publishers: Taylor & Francis. Release Date: 20080922. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Editorial. Language: English. Major Descriptor: Mental Health; Mental Health Services; Physical Health; Public Health; Health Care Policy. Minor Descriptor: Clinical Practice. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Sum 2008.
AB - Public mental health consumers are at risk of dying 25 years younger than other people of similar ages. On the surface, this is an astonishing and very unsettling number. What is even more disconcerting is that most of these years are lost because public mental health consumers do not receive even minimal physical health care. They are dying from untreated high blood pressure and stroke, untreated diabetes, untreated chronic heart disease, the direct consequences of smoking and the use of other noxious substances, and the unintended consequences of the metabolic side effects of the medications designed to address psychiatric illnesses. Contrary to popular belief, only a few of these years are lost due to suicide as a result of mental illness. The papers in this issue address different aspects of how we can move toward more effective approaches to wellness by improving practice and policy, data, and training. These three papers were developed specifically as background materials for the U.S. Center for Mental Health Services (CMHS) Wellness Summit. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public mental health consumers
KW - physical health care
KW - mental health services
KW - health care policy
KW - clinical practice
KW - 2008
KW - Mental Health
KW - Mental Health Services
KW - Physical Health
KW - Public Health
KW - Health Care Policy
KW - Clinical Practice
KW - 2008
DO - 10.2753/IMH0020-7411370200
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08538-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06791-001
AN - 2008-06791-001
AU - Hearld, Larry R.
AU - Alexander, Jeffrey A.
AU - Fraser, Irene
AU - Jiang, H. Joanna
T1 - How do hospital organizational structure and processes affect quality of care? A critical review of research methods.
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2008/06//
VL - 65
IS - 3
SP - 259
EP - 299
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
N1 - Accession Number: 2008-06791-001. PMID: 18089769 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Hearld, Larry R.; University of Michigan School of Public Health, Ann Arbor, MI, US. Release Date: 20090413. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Health Care Services; Hospitals; Organizations; Quality of Care. Classification: Health & Mental Health Services (3370). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 41. Issue Publication Date: Jun, 2008.
AB - Interest in organizational contributions to the delivery of care has risen significantly in recent years. A challenge facing researchers, practitioners, and policy makers is identifying ways to improve care by improving the organizations that provide this care, given the complexity of health care organizations and the role organizations play in influencing systems of care. This article reviews the literature on the relationship between the structural characteristics and organizational processes of hospitals and quality of care. The review uses Donabedian's structure-process-outcome and level of analysis frameworks to organize the literature. The results of this review indicate that a preponderance of studies are conducted at the hospital level of analysis and are predominantly focused on the organizational structure-quality outcome relationship. The article concludes with recommendations of how health services researchers can expand their research to enhance one's understanding of the relationship between organizational characteristics and quality of care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospital organizational structure
KW - quality of care
KW - hospitals
KW - organizational characteristics
KW - health care delivery
KW - 2008
KW - Health Care Delivery
KW - Health Care Services
KW - Hospitals
KW - Organizations
KW - Quality of Care
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1177/1077558707309613
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06791-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06800-012
AN - 2008-06800-012
AU - Shin, Rick
AU - Qin, Mei
AU - Liu, Zhong-Hua
AU - Ikemoto, Satoshi
T1 - Intracranial self-administration of MDMA into the ventral striatum of the rat: Differential roles of the nucleus accumbens shell, core, and olfactory tubercle.
JF - Psychopharmacology
JO - Psychopharmacology
JA - Psychopharmacology (Berl)
Y1 - 2008/06//
VL - 198
IS - 2
SP - 261
EP - 270
CY - Germany
PB - Springer
SN - 0033-3158
SN - 1432-2072
AD - Ikemoto, Satoshi, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 251 Bayview Boulevard, Room 08A711, Baltimore, MD, US, 21224
N1 - Accession Number: 2008-06800-012. PMID: 18389222 Other Journal Title: Psychopharmacologia. Partial author list: First Author & Affiliation: Shin, Rick; Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD, US. Release Date: 20080616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Self Administration; Methylenedioxymethamphetamine; Nucleus Accumbens; Olfactory Bulb; Striatum. Minor Descriptor: Pharmacology; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jun, 2008.
AB - Rationale: Behavioral and anatomical data suggest that the ventral striatum, consisting of the nucleus accumbens and olfactory tubercle, is functionally heterogeneous. Cocaine and D-amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core. Objectives: We sought to determine whether rats self-administer the popular recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA) into ventrostriatal subregions and whether the medial olfactory tubercle and medial accumbens shell mediate MDMA's positive reinforcing effects more effectively than their lateral counterparts. Results: Rats receiving 30 mM MDMA into the medial olfactory tubercle, medial accumbens shell, or accumbens core, but not the lateral tubercle or lateral shell, showed higher self-administration rates than rats receiving vehicle. The medial shell supported more vigorous self-administration of MDMA at higher concentrations than the core or medial olfactory tubercle. In addition, intra-medial shell MDMA self-administration was disrupted by co-administration of the D1 or D2 receptor antagonists SCH 23390 (1-3 mM) or raclopride (3-10 mM). Conclusions: Our data suggest that the ventral striatum is functionally heterogeneous. The medial accumbens shell appears to be more important than other ventrostriatal subregions in mediating the positive reinforcing effects of MDMA via both D1- and D2-type receptors. Together with previous data, our data also suggest that unidentified actions of MDMA interfere with the positive reinforcing effects of dopamine in the medial olfactory tubercle. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - methylenedioxymethamphetamine
KW - rats
KW - intracranial self-administration
KW - nucleus accumbens shell
KW - accumbens core
KW - olfactory tubercle
KW - ventral striatum
KW - 2008
KW - Drug Self Administration
KW - Methylenedioxymethamphetamine
KW - Nucleus Accumbens
KW - Olfactory Bulb
KW - Striatum
KW - Pharmacology
KW - Rats
KW - 2008
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, US. Recipients: No recipient indicated
DO - 10.1007/s00213-008-1131-x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06800-012&site=ehost-live&scope=site
UR - ORCID: 0000-0002-0732-7386
UR -
UR - sikemoto@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16925-007
AN - 2008-16925-007
AU - Baldwin, Laura-Mae
AU - Hollow, Walter B.
AU - Casey, Susan
AU - Hart, L. Gary
AU - Larson, Eric H.
AU - Moore, Kelly
AU - Lewis, Ervin
AU - Andrilla, C. Holly A.
AU - Grossman, David C.
T1 - Access to specialty health care for rural American Indians in two states.
JF - The Journal of Rural Health
JO - The Journal of Rural Health
JA - J Rural Health
Y1 - 2008///Sum 2008
VL - 24
IS - 3
SP - 269
EP - 278
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0890-765X
SN - 1748-0361
AD - Baldwin, Laura-Mae, University of Washington, Department of Family Medicine, Box 354982, Seattle, WA, US, 98195-4982
N1 - Accession Number: 2008-16925-007. PMID: 18643804 Partial author list: First Author & Affiliation: Baldwin, Laura-Mae; Department of Family Medicine, University of Washington School of Medicine, Seattle, WA, US. Other Publishers: Blackwell Publishing. Release Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Health Care Delivery; Health Care Services; Rural Environments. Minor Descriptor: Physicians. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sum 2008. Copyright Statement: National Rural Health Association. 2008.
AB - Context: The Indian Health Service (IHS), whose per capita expenditure for American Indian and Alaska Native (AI/AN) health services is about half that of the US civilian population, is the only source of health care funding for many rural AI/ANs. Specialty services, largely funded through contracts with outside practitioners, may be limited by low IHS funding levels. Purpose: To examine specialty service access among rural Indian populations in two states. Methods: A 31-item mail survey addressing perceived access to specialty physicians, barriers to access, and access to non-physician clinical services was sent to 106 primary care providers in rural Indian health clinics in Montana and New Mexico (overall response rate 60.4%) and 95 primary care providers in rural non-Indian clinics within 25 miles of the Indian clinics (overall response rate 57.9%). Findings: Substantial proportions of rural Indian clinic providers in both states reported fair or poor non-emergent specialty service access for their patients. Montana's rural Indian clinic providers reported poorer patient access to specialty care than rural non-Indian clinic providers, while New Mexico's rural Indian and non-Indian providers reported comparable access. Indian clinic providers in both states most frequently cited financial barriers to specialty care. Indian clinic providers reported better access to most non-physician services than non-Indian clinic providers. Conclusions: Reported limitations in specialty care access for rural Indian clinic patients appear to be influenced by financial constraints. Health care systems factors may play a role in perceived differences in specialty access between rural Indian and non-Indian clinic patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - access to speciality health care
KW - health care services
KW - rural environments
KW - American Indians
KW - Alaska Natives
KW - specialty physicians
KW - 2008
KW - Alaska Natives
KW - American Indians
KW - Health Care Delivery
KW - Health Care Services
KW - Rural Environments
KW - Physicians
KW - 2008
U1 - Sponsor: University of Washington Rural Health Research Center, Rural Health Research Center, US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration, Office of Rural Health Policy. Recipients: No recipient indicated
DO - 10.1111/j.1748-0361.2008.00168.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16925-007&site=ehost-live&scope=site
UR - lmb@fammed.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-07166-003
AN - 2008-07166-003
AU - Colliver, James D.
AU - Gfroerer, Joseph C.
T1 - Motive for nonmedical use of prescription pain relievers in the National Survey on Drug Use and Health.
JF - The Journal of Pain
JO - The Journal of Pain
JA - J Pain
Y1 - 2008/06//
VL - 9
IS - 6
SP - 487
EP - 489
CY - Netherlands
PB - Elsevier Science
SN - 1526-5900
AD - Colliver, James D., Division of Population Surveys, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1033, Rockville, MD, US, 20857
N1 - Accession Number: 2008-07166-003. PMID: 18403270 Partial author list: First Author & Affiliation: Colliver, James D.; Division of Population Surveys, Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20081117. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Abuse; Motivation; Opiates; Prescription Drugs. Classification: Substance Abuse & Addiction (3233). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jun, 2008.
AB - Comments on an article by Zacny and Lichtor (see record [rid]2008-07166-002[/rid]). Zacny and Lichtor recommend that the questions on nonmedical use of prescription pain relievers in the National Survey on Drug Use and Health (NSDUH) be enhanced to collect information on the motive for such use so that use for pain relief can be differentiated from use for recreational purposes. We recognize, as Zacny and Lichtor point out, that the definition includes some people who use these medications without a prescription of their own but as self-treatment for actual health problems. We also recognize that self-treatment without a prescription may not constitute 'misuse,' 'abuse,' or 'recreational use' as ordinarily understood, we nevertheless are concerned that such self-treatment occurs without a physician's evaluation or monitoring and thereby may pose risks, a concern that Zacny and Lichtor endorse. The suggestion of Zacny and Lichtor that separate questions on motive for nonmedical use of pain relievers be added to the NSDUH is an interesting one in that it could be implemented without changing the basic definition of nonmedical use, thus finessing the problem of maintaining consistency with existing measures and allowing trend analysis while supporting the differentiation of nonmedical users who use the drugs for their legitimately intended purposes of pain relief, albeit without a prescription. In conclusion, we concur with the points raised by Zacny and Lichtor regarding the need for more detailed information about the reasons for nonmedical use of prescription pain relievers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nonmedical use
KW - prescription opioids
KW - motivation
KW - 2008
KW - Drug Abuse
KW - Motivation
KW - Opiates
KW - Prescription Drugs
KW - 2008
DO - 10.1016/j.jpain.2008.03.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07166-003&site=ehost-live&scope=site
UR - James.Colliver@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-07285-001
AN - 2008-07285-001
AU - Snowden, Lonnie R.
AU - Masland, Mary
AU - Wallace, Neal
AU - Fawley-King, Kya
AU - Cuellar, Alison Evans
T1 - Increasing California children's Medicaid-financed mental health treatment by vigorously implementing Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2008/06//
VL - 46
IS - 6
SP - 558
EP - 564
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Snowden, Lonnie R., University of California Berkeley, 120 Haviland Hall, Berkeley, CA, US, 94720-7400
N1 - Accession Number: 2008-07285-001. PMID: 18520309 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; School of Social Welfare, University of California Berkeley, Berkeley, CA, US. Release Date: 20090706. Correction Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Snowden, Lonnie R. Major Descriptor: Diagnosis; Medicaid; Mental Health Programs; Mental Health Services; Poverty. Minor Descriptor: Health Screening; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2008.
AB - Background: Children living in poverty--especially children living in rural areas and in areas lacking a commitment to providing mental health care--have considerable unmet need for mental health treatment. Expansion of Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program might help to address this problem. Objective: To evaluate whether a legally compelled expansion of mental health screening, treatment, and financing under EPSDT would translate into higher Medicaid penetration rates. Our particular focus was on changes in rural treatment systems and systems historically receiving low levels of state funding (ie, 'underequity' counties). Methods: We used fixed-effects regression methods by observing 53 California county mental health plans over 36 quarters, yielding 1908 observations. Our models controlled for all static, county, and service system characteristics, and for ongoing linear trends in penetration rates. Results: After controlling for previous trends, mental health treatment access increased following EPSDT mental health program expansion. The increase was greatest in rural systems, and counties that previously received less state funding which showed the greatest penetration rate increases. Conclusions: EPSDT mental health expansion and increased funding increased Medicaid-financed mental health treatment. The expansion efforts had the greatest effects in rural and underequity counties that faced the greatest barriers to mental health service use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Medicaid financed mental health for children
KW - treatment
KW - diagnosis
KW - mental health service
KW - poverty
KW - 2008
KW - Diagnosis
KW - Medicaid
KW - Mental Health Programs
KW - Mental Health Services
KW - Poverty
KW - Health Screening
KW - Mental Health
KW - 2008
U1 - Sponsor: California HealthCare Foundation, US. Recipients: Snowden, Lonnie R.; Masland, Mary; Wallace, Neal; Fawley-King, Kya; Cuellar, Alison Evans
U1 - Sponsor: California Department of Mental Health, US. Recipients: Snowden, Lonnie R.; Masland, Mary; Wallace, Neal; Fawley-King, Kya; Cuellar, Alison Evans
DO - 10.1097/MLR.0b013e3181648e82
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07285-001&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17535-015
AN - 2008-17535-015
AU - Bell, Carl C.
AU - Sowers, Wesley
AU - Thompson, Kenneth S.
T1 - American association of community psychiatrists' views on general features of DSM-IV.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/06//
VL - 59
IS - 6
SP - 687
EP - 689
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Bell, Carl C., University of Illinois at Chicago, 8704 S. Constance Ave., Chicago, IL, US, 60617
N1 - Accession Number: 2008-17535-015. PMID: 18511591 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Bell, Carl C.; University of Illinois at Chicago, Chicago, IL, US. Release Date: 20090316. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Psychiatry; Diagnostic and Statistical Manual; Health Personnel Attitudes; Psychiatrists. Minor Descriptor: American Psychological Association. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Jun, 2008.
AB - Objective: The authors report on a survey of the American Association of Community Psychiatrists (AACP) about improving DSM-IV. Methods: An anonymous survey was sent to 600 psychiatrists of the AACP via Survey Monkey technology. Results: Respondents (N = 152) answered questionnaires regarding the general features of DSM-IV. Reliable inter clinician communication was valued most highly. A majority of respondents (92%) reported using axis 1, 75% used axes 2 and 3, and approximately 50% used axes 4 and 5. AACP members were less keen on using the tool to inform patient management planning. Least valued were usefulness for a national statistical base or to indicate prognosis. Conclusions: AACP respondents’ views suggest modification to the DSM system to improve clinical utility. Most favored fewer than 100 diagnostic categories. Many were concerned about the current systems’ cultural sensitivity and accessibility to patients. These considerations should guide DSM-V deliberations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Diagnostic and Statistical Manual-IV
KW - community psychiatrists' views
KW - American Association of Community Psychiatrists
KW - psychiatrists view
KW - 2008
KW - Community Psychiatry
KW - Diagnostic and Statistical Manual
KW - Health Personnel Attitudes
KW - Psychiatrists
KW - American Psychological Association
KW - 2008
DO - 10.1176/appi.ps.59.6.687
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17535-015&site=ehost-live&scope=site
UR - carlcbell@pol.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08308-006
AN - 2008-08308-006
AU - West, Christine
AU - Bernard, Bruce
AU - Mueller, Charles
AU - Kitt, Margaret
AU - Driscoll, Richard
AU - Tak, Sangwoo
T1 - Mental health outcomes in police personnel after Hurricane Katrina.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2008/06//
VL - 50
IS - 6
SP - 689
EP - 695
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - West, Christine, CDC, NIOSH, DSHEFS, 4676 Columbia Parkway R-10, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-08308-006. PMID: 18545096 Partial author list: First Author & Affiliation: West, Christine; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, OH, US. Release Date: 20090511. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Major Depression; Natural Disasters; Police Personnel; Posttraumatic Stress Disorder; Symptoms. Minor Descriptor: Mental Health; Treatment Outcomes. Classification: Psychological Disorders (3210); Police & Legal Personnel (4290). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: structured clinical interview using criteria from the Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition; PTSD Checklist; Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2008.
AB - Objective: We examined symptoms of depression and post traumatic stress disorder (PTSD) among New Orleans Police Department (NOPD) personnel who provided law enforcement and relief services to affected communities following Hurricane Katrina. Methods: We conducted a cross-sectional survey of mental health outcomes related to personal and work-related exposures of police personnel 8 weeks after the Hurricane. Results: Of the 912 police personnel who completed the questionnaire, 227 (26%) reported symptoms consistent with depression and 170 (19%) reported symptoms consistent with PTSD. Risk factors associated with PTSD include recovery of bodies, crowd control, assault, and injury to a family member. Depressive symptoms were associated with rare family contact, uninhabitable home, isolation from the NOPD, assault, and injury to a family member. Conclusions: Police personnel reported symptoms of PTSD and depression associated with work-related and personal factors following Hurricane Katrina. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - treatment outcomes
KW - police personnel
KW - Hurricane Katrina
KW - major depression
KW - posttraumatic stress disorder
KW - symptoms
KW - 2008
KW - Major Depression
KW - Natural Disasters
KW - Police Personnel
KW - Posttraumatic Stress Disorder
KW - Symptoms
KW - Mental Health
KW - Treatment Outcomes
KW - 2008
DO - 10.1097/JOM.0b013e3181638685
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08308-006&site=ehost-live&scope=site
UR - cawest@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08381-008
AN - 2008-08381-008
AU - Levy, Alan S.
AU - Choinière, Conrad J.
AU - Fein, Sara B.
T1 - Practice-specific risk perceptions and self-reported food safety practices.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2008/06//
VL - 28
IS - 3
SP - 749
EP - 761
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0272-4332
SN - 1539-6924
AD - Choinière, Conrad J., Office of Regulations, Policy and Social Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, US, 20740
N1 - Accession Number: 2008-08381-008. PMID: 18643830 Partial author list: First Author & Affiliation: Levy, Alan S.; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090706. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Food; Risk Management; Risk Perception; Safety. Minor Descriptor: Food Safety. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jun, 2008.
AB - The relationship between risk perception and risk avoidance is typically analyzed using self reported measures. However, in domains such as driving or food handling, the validity of responses about usual behavior is threatened because people think about the situations in which they are self-aware, such as when they encounter a hazard. Indeed, researchers have often noted a divergence between what people say about their behavior and how they actually behave. Thus, in order to draw conclusions about risk perceptions and risk avoidance from survey data, it is important to identify particular cognitive elements, such as those measured by questions about risk and safety knowledge, risk perceptions, or information search behavior, which may be effective antecedents of self-reported safety behavior. It is also important to identify and correct for potential sources of bias that may exist in the data. The authors analyze the Food and Drug Administration's 1998 Food Safety Survey to determine whether there are consistent cognitive antecedents for three types of safe food practices: preparation, eating, and cooling of foods. An assessment of measurement biases shows that endogeneity of food choices affects reports of food preparation. In addition, response bias affects reports of cooling practices as evidenced by its relation to knowledge and information search, a pattern of cognitive effects unique to cooling practices. After correcting for these biases, results show that practice-specific risk perceptions are the primary cognitive antecedents of safe food behavior, which has implications for the design of effective education messages about food safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - practice specific risk perceptions
KW - self report
KW - food safety practices
KW - risk avoidance
KW - 2008
KW - Food
KW - Risk Management
KW - Risk Perception
KW - Safety
KW - Food Safety
KW - 2008
DO - 10.1111/j.1539-6924.2008.01051.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08381-008&site=ehost-live&scope=site
UR - conrad.choiniere@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-07042-040
AN - 2008-07042-040
AU - Kongkaneramit, Lalana
AU - Sarisuta, Narong
AU - Azad, Neelam
AU - Lu, Yongju
AU - Iyer, Anand Krishnan V.
AU - Wang, Liying
AU - Rojanasakul, Yon
T1 - Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells.
JF - The Journal of Pharmacology and Experimental Therapeutics
JO - The Journal of Pharmacology and Experimental Therapeutics
JA - J Pharmacol Exp Ther
Y1 - 2008/06//
VL - 325
IS - 3
SP - 969
EP - 977
CY - US
PB - American Society for Pharmacology & Experimental Therapeutics ASPET
SN - 0022-3565
SN - 1521-0103
AD - Rojanasakul, Yon, West Virginia University, Health Sciences Center, Department of Pharmaceutical Sciences, P.O. Box 9530, Morgantown, WV, US, 26506
N1 - Accession Number: 2008-07042-040. PMID: 18354056 Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Kongkaneramit, Lalana; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, US. Release Date: 20080901. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Rojanasakul, Yon. Major Descriptor: Apoptosis; Epithelial Cells; Genes; Proteins; Reactive Oxygen Species. Minor Descriptor: Gene Expression; Lung; Oxygen; Pharmacology. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jun, 2008.
AB - Cationic liposomes such as lipofectamine (LF) are widely used as nonviral gene delivery vectors; however, their clinical application is limited by their cytotoxicity. These agents have been shown to induce apoptosis as the primary mode of cell death, but their mechanism of action is not well understood. The present study investigated the mechanism of LF-induced apoptosis and examined the role of reactive oxygen species (ROS) in this process. We found that LF induced apoptosis of human epithelial H460 cells through a mechanism that involves caspase activation and ROS generation. Inhibition of caspase activity by pan-caspase inhibitor (z-VAD-fmk) or by specific caspase-8 inhibitor (z-IETD-fmk) or caspase-9 inhibitor (z-LEHD-fmk) inhibited the apoptotic effect of LF. Overexpression of FLICE-inhibitory protein (FLIP) or B-cell lymphoma-2, which are known inhibitors of the extrinsic and intrinsic death pathways, respectively, similarly inhibited apoptosis by LF. Induction of apoptosis by LF was shown to require ROS generation because its inhibition by ROS scavengers or by ectopic expression of antioxidant enzyme superoxide dismutase and glutathione peroxidase strongly inhibited the apoptotic effect of LF. Electron spin resonance studies showed that LF induced multiple ROS; however, superoxide was found to be the primary ROS responsible for LF-induced apoptosis. The mechanism by which ROS mediate the apoptotic effect of LF involves down-regulation of FLIP through the ubiquitination pathway. In demonstrating the role of FLIP and ROS in LF death signaling, we document a novel mechanism of apoptosis regulation that may be exploited to decrease cytotoxicity and increase gene transfection efficiency of cationic liposomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - reactive oxygen species
KW - FLICE inhibitory protein
KW - lipofectamine-induced apoptosis
KW - human lung epithelial cells
KW - 2008
KW - Apoptosis
KW - Epithelial Cells
KW - Genes
KW - Proteins
KW - Reactive Oxygen Species
KW - Gene Expression
KW - Lung
KW - Oxygen
KW - Pharmacology
KW - 2008
U1 - Sponsor: National Institutes of Health, US. Grant: R01HL76340. Recipients: Rojanasakul, Yon
DO - 10.1124/jpet.107.136077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07042-040&site=ehost-live&scope=site
UR - ORCID: 0000-0002-8839-6462
UR -
UR - yrojan@hsc.wvu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Tumuluri, Venkat S.
AU - Kemper, Mark S.
AU - Lewis, Ian R.
AU - Prodduturi, Suneela
AU - Majumdar, Soumyajit
AU - Avery, Bonnie A.
AU - Repka, Michael A.
T1 - Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/06/05/
VL - 357
IS - 1/2
M3 - Article
SP - 77
EP - 84
SN - 03785173
AB - Abstract: The objective of this study was to investigate the use of Raman spectroscopy for the quantitative and qualitative analysis of an active ingredient in hot-melt extruded film formulations. Clotrimazole and ketoprofen were used as the active pharmaceutical ingredients (APIs) in the subject formulations. Films were prepared with contents varying from 1 to 20% of the respective API. Raman spectroscopy was used to quantify these APIs, both off-line and on-line. The spectral data were also used to ascertain the physical status of these APIs in the formulations. For off-line analysis, the films were cut into small rectangles, and the amount of the API was measured using a fiber optic probe equipped with a non-contact optic (NCO). For on-line analysis, real-time measurements were accomplished by fixing the probe over the extruded film for continuous data collection. Raman spectroscopy can be a convenient alternative to HPLC and other techniques currently employed for the quantification of the API in these formulations. Because Raman is also sensitive to changes in crystallinity, employment of the technique provided additional information to deduce the crystalline status of the API. The results reported in this paper suggest the suitability of Raman for PAT applications because of the on-line capability. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAMAN spectroscopy
KW - DRUGS
KW - PHOTOGRAPHIC film
KW - MEASUREMENT
KW - Hot-melt extrusion
KW - On-line monitoring
KW - PAT
KW - Process analysis
KW - Raman spectroscopy
N1 - Accession Number: 31921569; Tumuluri, Venkat S. 1 Kemper, Mark S. 2 Lewis, Ian R. 2 Prodduturi, Suneela 3 Majumdar, Soumyajit 1 Avery, Bonnie A. 1 Repka, Michael A. 1; Email Address: marepka@olemiss.edu; Affiliation: 1: Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, P.O. Box 1848, University, MS 38677, USA 2: Kaiser Optical Systems, Ann Arbor, MI, USA 3: Food and Drug Administration, St. Louis, MO, USA; Source Info: Jun2008, Vol. 357 Issue 1/2, p77; Subject Term: RAMAN spectroscopy; Subject Term: DRUGS; Subject Term: PHOTOGRAPHIC film; Subject Term: MEASUREMENT; Author-Supplied Keyword: Hot-melt extrusion; Author-Supplied Keyword: On-line monitoring; Author-Supplied Keyword: PAT; Author-Supplied Keyword: Process analysis; Author-Supplied Keyword: Raman spectroscopy; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 326114 Plastic film and sheet manufacturing; NAICS/Industry Codes: 414430 Photographic equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423410 Photographic Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 443145 Camera and photographic supplies stores; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 325992 Photographic Film, Paper, Plate, and Chemical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijpharm.2008.01.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31921569&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marcucci, Katherine T.
AU - Martina, Yuri
AU - Harrison, Frank
AU - Wilson, Carolyn A.
AU - Salomon, Daniel R.
T1 - Functional hierarchy of two L domains in porcine endogenous retrovirus (PERV) that influence release and infectivity
JO - Virology
JF - Virology
Y1 - 2008/06/05/
VL - 375
IS - 2
M3 - Article
SP - 637
EP - 645
SN - 00426822
AB - Abstract: The porcine endogenous retrovirus (PERV) Gag protein contains two late (L) domain motifs, PPPY and P(F/S)AP. Using viral release assays we demonstrate that PPPY is the dominant L domain involved in PERV release. PFAP represents a novel retroviral L domain variant and is defined by abnormal viral assembly phenotypes visualized by electron microscopy and attenuation of early PERV release as measured by viral genomes. PSAP is functionally dominant over PFAP in early PERV release. PSAP virions are 3.5-fold more infectious in vitro by TCID50 and in vivo results in more RNA positive tissues and higher levels of proviral DNA using our human PERV-A receptor (HuPAR-2) transgenic mouse model [Martina, Y., Marcucci, K.T., Cherqui, S., Szabo, A., Drysdale, T., Srinivisan, U., Wilson, C.A., Patience, C., Salomon, D.R., 2006. Mice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection. J. Virol. 80 (7), 3135–3146]. The functional hierarchies displayed by PERV L domains, demonstrates that L domain selection in viral evolution exists to promote efficient viral assembly, release and infectivity in the virus–host context. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSGENIC mice
KW - GENETICS
KW - GENOMICS
KW - GENOMES
KW - Infectivity
KW - Late (L) domains
KW - Porcine endogenous retrovirus (PERV)
KW - Viral assembly
N1 - Accession Number: 32069798; Marcucci, Katherine T. 1,2; Email Address: katiem@scripps.edu Martina, Yuri 1; Email Address: yuri.martina@adaltis.com Harrison, Frank 1; Email Address: harrison@scripps.edu Wilson, Carolyn A. 3; Email Address: carolyn.wilson@fda.hhs.gov Salomon, Daniel R. 1; Email Address: dsalomon@scripps.edu; Affiliation: 1: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA 2: Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA, 92037, USA 3: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD, 20892, USA; Source Info: Jun2008, Vol. 375 Issue 2, p637; Subject Term: TRANSGENIC mice; Subject Term: GENETICS; Subject Term: GENOMICS; Subject Term: GENOMES; Author-Supplied Keyword: Infectivity; Author-Supplied Keyword: Late (L) domains; Author-Supplied Keyword: Porcine endogenous retrovirus (PERV); Author-Supplied Keyword: Viral assembly; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2008.02.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32069798&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cierpich, H.
AU - Styles, L.
AU - Harrison, R.
AU - Davis, L.
AU - Chester, D.
AU - Lefkowitz, D.
AU - Valiante, D.
AU - Richardson, S.
AU - Castillo, D.
AU - Romano, N.
AU - Baron, S.
T1 - Work-Related Injury Deaths Among Hispanics -- United States, 1992-2006. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/06/06/
VL - 57
IS - 22
M3 - Article
SP - 597
EP - 600
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article reports on the findings of an analysis conducted by the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Bureau of Labor and Statistics (BLS) regarding work related injury deaths among Hispanic Americans during the period 1992-2006. According to the analysis, 34% of deaths involving Hispanics between 2003-2006 occurred in the construction industry. Also, the analysis found that homicide was the most common fatal event occurring to Hispanic Americans from 1992 to 1996.
KW - OCCUPATIONAL mortality
KW - HISPANIC Americans
KW - CONSTRUCTION industry
KW - HOMICIDE
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States. Bureau of Labor Statistics
N1 - Accession Number: 32653305; Cierpich, H. 1 Styles, L. 1 Harrison, R. 2 Davis, L. 3 Chester, D. 4 Lefkowitz, D. 5 Valiante, D. 5 Richardson, S. 6 Castillo, D. 7 Romano, N. 7 Baron, S. 7; Affiliation: 1: Public Health Institute, Oakland 2: Occupational Health Br, California Dept of Public Health 3: Occupational Surveillance Program, Massachusetts Dept of Public Health 4: Michigan State Univ. 5: New Jersey Dept of Health and Senior Svcs. 6: Bur of Labor Statistics, US Dept of Labor 7: National Institute for Occupational Safety and Health, CDC; Source Info: 6/6/2008, Vol. 57 Issue 22, p597; Subject Term: OCCUPATIONAL mortality; Subject Term: HISPANIC Americans; Subject Term: CONSTRUCTION industry; Subject Term: HOMICIDE; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: UNITED States. Bureau of Labor Statistics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 236110 Residential building construction; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 4p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32653305&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clancy, Carolyn
T1 - Improving Care Quality and Reducing Disparities.
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
Y1 - 2008/06/09/
VL - 168
IS - 11
M3 - Article
SP - 1135
EP - 1136
SN - 00039926
AB - The article discusses various reports published within the issue, including one by Thomas D. Sequist and colleagues on the performance of physician and racial disparities in diabetes mellitus care.
KW - RACIAL differences
KW - DIABETES -- Treatment
N1 - Accession Number: 32681686; Clancy, Carolyn 1; Email Address: carolyn.clancy@ahrq.hhs.gov; Affiliation: 1: Office of the Director, Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville; Source Info: 6/9/2008, Vol. 168 Issue 11, p1135; Subject Term: RACIAL differences; Subject Term: DIABETES -- Treatment; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32681686&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MohamedMohaideen, Nilofar N.
AU - Palaninathan, Satheesh K.
AU - Morin, Paul M.
AU - Williams, Brad J.
AU - Braunstein, Miriam
AU - Tichy, Shane E.
AU - Locker, Joseph
AU - Russell, David H.
AU - Jacobs Jr, William R.
AU - Sacchettini, James C.
T1 - Structure and Function of the Virulence-Associated High-Temperature Requirement A of Mycobacterium tuberculosis.
JO - Biochemistry
JF - Biochemistry
Y1 - 2008/06/10/
VL - 47
IS - 23
M3 - Article
SP - 6092
EP - 6102
SN - 00062960
AB - The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis (Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 Å resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM tuberculosis
KW - VIRULENCE (Microbiology)
KW - HIGH temperatures
KW - SERINE proteinases
KW - ESCHERICHIA coli
N1 - Accession Number: 32900120; MohamedMohaideen, Nilofar N. 1,2 Palaninathan, Satheesh K. 1,2 Morin, Paul M. 3 Williams, Brad J. 4 Braunstein, Miriam 5 Tichy, Shane E. 4 Locker, Joseph 6 Russell, David H. 4 Jacobs Jr, William R. 7; Email Address: jacobsw@hhmi.org Sacchettini, James C. 1; Email Address: sacchett@tamu.edu; Affiliation: 1: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843 2: Department of Chemistry, Texas A&M University, College Station, Texas 77842 3: Howard Hughes Medical Institute 4: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461 5: U.S. Food and Drug Administration, Microbiological Sciences Branch, Jamaica, New York 11433 6: Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 7: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461; Source Info: 6/10/2008, Vol. 47 Issue 23, p6092; Subject Term: MYCOBACTERIUM tuberculosis; Subject Term: VIRULENCE (Microbiology); Subject Term: HIGH temperatures; Subject Term: SERINE proteinases; Subject Term: ESCHERICHIA coli; Number of Pages: 11p; Illustrations: 2 Color Photographs, 11 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1021/bi701929m
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Im, Young Jun
AU - Hurley, James H.
T1 - Integrated Structural Model and Membrane Targeting Mechanism of the Human ESCRT-II Complex
JO - Developmental Cell
JF - Developmental Cell
Y1 - 2008/06/10/
VL - 14
IS - 6
M3 - Article
SP - 902
EP - 913
SN - 15345807
AB - Summary: ESCRT-II plays a pivotal role in receptor downregulation and multivesicular body biogenesis and is conserved from yeast to humans. The crystal structures of two human ESCRT-II complex structures have been determined at 2.6 and 2.9 Å resolution, respectively. The complex has three lobes and contains one copy each of VPS22 and VPS36 and two copies of VPS25. The structure reveals a dynamic helical domain to which both the VPS22 and VPS36 subunits contribute that connects the GLUE domain to the rest of the ESCRT-II core. Hydrodynamic analysis shows that intact ESCRT-II has a compact, closed conformation. ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix immediately C-terminal to the VPS36-GLUE domain. ESCRT-II is targeted to endosomal membranes by the lipid-binding activities of both the Vps36 GLUE domain and the first helix of Vps22. These data provide a unifying structural and functional framework for the ESCRT-II complex. [Copyright &y& Elsevier]
AB - Copyright of Developmental Cell is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOSOMES
KW - CELL organelles
KW - YEAST
KW - HYDRODYNAMICS
KW - FLUID dynamics
KW - CELLBIO
KW - PROTEINS
N1 - Accession Number: 32557029; Im, Young Jun 1 Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA; Source Info: Jun2008, Vol. 14 Issue 6, p902; Subject Term: ENDOSOMES; Subject Term: CELL organelles; Subject Term: YEAST; Subject Term: HYDRODYNAMICS; Subject Term: FLUID dynamics; Author-Supplied Keyword: CELLBIO; Author-Supplied Keyword: PROTEINS; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.devcel.2008.04.004
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Haffner, Marlene E.
AU - Torrent-Farnell, Josep
AU - Maher, Paul D.
T1 - Does orphan drug legislation really answer the needs of patients?
JO - Lancet
JF - Lancet
Y1 - 2008/06/14/
VL - 371
IS - 9629
M3 - Editorial
SP - 2041
EP - 2044
SN - 00995355
AB - The author offers opinions on so-called "orphan" drug legislation which creates financial incentives for drugs for rare diseases to be produced and marketed by pharmaceutical companies. Both the U.S. and European Union (EU) have such laws, and in the U.S., it has succeeded in helping bring 300 new drugs to market since the law was passed in 1983. The cost of treatment with such drugs, however, remains quite expensive. It is noted that drugs for diseases which are common in developing countries, such as tuberculosis, qualify as "orphan" drugs in the U.S. due to the rarity of that disease there.
KW - DRUG laws & regulations
KW - PHARMACEUTICAL policy
KW - PHARMACEUTICAL industry
KW - MYCOBACTERIAL diseases
KW - LEGISLATION
KW - UNITED States
KW - EUROPEAN Union
N1 - Accession Number: 32640951; Haffner, Marlene E. 1; Email Address: marlene.haffner@amgen.com Torrent-Farnell, Josep 2 Maher, Paul D. 2; Affiliation: 1: Amgen, Washington, DC, USA 2: Office of Orphan Products Development, Food and Drug Administration, Rockville, MD, USA; Source Info: 6/14/2008, Vol. 371 Issue 9629, p2041; Subject Term: DRUG laws & regulations; Subject Term: PHARMACEUTICAL policy; Subject Term: PHARMACEUTICAL industry; Subject Term: MYCOBACTERIAL diseases; Subject Term: LEGISLATION; Subject Term: UNITED States; Company/Entity: EUROPEAN Union; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Document Type: Editorial
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ward, Michael M.
AU - Reveille, John D.
AU - Learch, Thomas J.
AU - Davis Jr., John C.
AU - Weisman, Michael H.
T1 - Occupational Physical Activities and Long-Term Functional and Radiographic Outcomes in Patients With Ankylosing Spondylitis.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2008/06/15/
VL - 58
IS - 6
M3 - Article
SP - 822
EP - 832
SN - 00043591
AB - The article presents a study which identified occupational physical activities associated with functional limitations and radiographic damage in patients with ankylosing spondylitis (AS). Ratings for the physical abilities of patients diagnosed with AS for more than 20 years were obtained and were related to the degree of functional limitation and the extent of spinal radiographic damage.
KW - ANKYLOSING spondylitis
KW - PATIENTS
KW - PHYSICAL fitness testing
KW - ACTIVITIES of daily living
KW - RADIOGRAPHY
KW - RESEARCH
N1 - Accession Number: 32618561; Ward, Michael M. 1; Email Address: wardm1@mail.nih.gov Reveille, John D. 2 Learch, Thomas J. 3 Davis Jr., John C. 4 Weisman, Michael H. 3; Affiliation: 1: National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland 2: University of Texas Health Sciences Center, Houston 3: Cedars-Sinai Medical Center, Los Angeles, California 4: University of California, San Francisco; Source Info: Jun2008, Vol. 58 Issue 6, p822; Subject Term: ANKYLOSING spondylitis; Subject Term: PATIENTS; Subject Term: PHYSICAL fitness testing; Subject Term: ACTIVITIES of daily living; Subject Term: RADIOGRAPHY; Subject Term: RESEARCH; Number of Pages: 11p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1002/art.23704
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105785506
T1 - Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis.
AU - Ward MM
AU - Reveille JD
AU - Learch TJ
AU - Davis JC Jr
AU - Weisman MH
Y1 - 2008/06/15/2008 Jun
N1 - Accession Number: 105785506. Language: English. Entry Date: 20080808. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0370605.
KW - Motor Activity -- Physiology
KW - Occupations and Professions
KW - Spondylitis, Ankylosing -- Physiopathology
KW - Spondylitis, Ankylosing -- Radiography
KW - Female
KW - Male
KW - Middle Age
KW - Vibration -- Adverse Effects
KW - Human
SP - 822
EP - 832
JO - Arthritis & Rheumatism: Arthritis Care & Research
JF - Arthritis & Rheumatism: Arthritis Care & Research
JA - ARTHRITIS RHEUM (ARTHRITIS CARE RES)
VL - 59
IS - 6
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland
U2 - PMID: 18512723.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, K. A.
AU - Sethajintanin, D.
AU - Sower, G.
AU - Quarles, L.
T1 - Field Trial and Modeling of Uptake Rates of In Situ Lipid-Free Polyethylene Membrane Passive Sampler.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2008/06/15/
VL - 42
IS - 12
M3 - Article
SP - 4486
EP - 4493
SN - 0013936X
AB - Lipid-free polyethylene membrane tubing (LFT) has been further developed in response to a growing need for an inexpensive and simple time-integrative sampling device for dissolved hydrophobic contaminants in water. The LFT sampler is based on the diffusion of dissolved hydrophobic target compounds through the aqueous boundary layer and into the polyethylene membrane, mimicking uptake by organisms. We demonstrate through laboratory and field validation studies that LFT provided the same benefits as many other passive sampling devices, without the potential of analytical interference from lipid impurities. A total of 370 LFTs and semipermeable membrane devices were deployed for 21 days in paired studies at highly urbanized, undeveloped, and two Superfund sites, representing several river conditions. A simple internal surrogate spiking method served as an in situ calibration indicator of the effects of environmental conditions on the uptake rates. A modified extraction method for the LFT increased recoveries while decreasing solvent use and labor compared to other organic extraction procedures. LFT sampling rates were estimated using ratios, in situ calibration and modeling for over 45 target analytes, including PAHs, PCBs, and pesticides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polyethylene
KW - Water pollution -- Research
KW - RESEARCH
KW - Water quality -- Research
KW - Hydrophobic surfaces
KW - Rivers
KW - Sampling (Process)
N1 - Accession Number: 32830126; Anderson, K. A. 1; Email Address: Kim.anderson@orst.edu; Sethajintanin, D. 2; Email Address: doolalai@fda.moph.go.th; Sower, G. 1; Quarles, L. 1; Affiliations: 1: Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, Oregon 97331.; 2: Hazardous Substances Control Division, Bureau of Cosmetics and Hazardous Substances Control, Food and Drug Administration, Ministry of Public Health, 8/24 Tivanont Road, Nonthaburi 11000, Thailand.; Issue Info: 6/15/2008, Vol. 42 Issue 12, p4486; Thesaurus Term: Polyethylene; Thesaurus Term: Water pollution -- Research; Thesaurus Term: RESEARCH; Thesaurus Term: Water quality -- Research; Subject Term: Hydrophobic surfaces; Subject Term: Rivers; Subject Term: Sampling (Process); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Date, Anand A.
AU - Kyaw, Moe H.
AU - Rue, Alison M.
AU - Klahn, Julie
AU - Obrecht, LeAnn
AU - Krohn, Terry
AU - Rowland, Josh
AU - Rubin, Steve
AU - Safranek, Thomas J.
AU - Bellini, William J.
AU - Dayan, Gustavo H.
T1 - Long-Term Persistence of Mumps Antibody after Receipt of 2 Measles-Mumps-Rubella (MMR)Vaccinations and Antibody Response after a Third MMR Vaccination among a University Population.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/06/15/
VL - 197
IS - 12
M3 - Article
SP - 1662
EP - 1668
SN - 00221899
AB - Background. High attack rates among vaccinated young adults reported during the 2006 mumps outbreak in the United States heightened concerns regarding mumps vaccine failure. Methods. Serum specimens from university students and staff were tested for mumps immunoglobulin (Ig) G by enzyme immunoassay (EIA). A subset of participants vaccinated for ⩽5 years and ⩾15 years were tested by neutralizing antibody (NA) assay. Persons seronegative by EIA were offered a third dose of measles-mumps-rubella vaccine (MMR3), and serum specimens were obtained 7-10 days and 2-3 months after its administration. Results. Overall, 94% (95% confidence interval [CI], 91%-96%) of the 440 participants were seropositive. No differences existed in seropositivity rates by sex, age, age at receipt of the second dose of MMR vaccine (MMR2), or time since receipt of MMR2 (P = .568). The geometric mean titer (GMT) of NA among persons vaccinated with MMR2 during the previous 1-5 years was 97 (95% CI, 64-148), whereas, among those vaccinated ⩾15 years before blood collection, the GMT was 58 (95% CI, 44-76) (P = .065). After MMR3, 82% (14/17) and 91% (10/11) seroconverted in 7-10 days and 2-3 months, respectively. Conclusions. Lower levels of NA observed among persons who received MMR2 ⩾15 years ago demonstrates antibody decay over time. MMR3 vaccination of most seronegative persons marked the capacity to mount an anamnestic response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUMPS
KW - PAROTID glands -- Diseases
KW - PAROTITIS
KW - IMMUNIZATION
KW - COMMUNICABLE diseases -- Prevention
KW - PREVENTIVE medicine
KW - VIRUS diseases
KW - MEDICAL virology
KW - ENZYME-linked immunosorbent assay
N1 - Accession Number: 32586562; Date, Anand A. 1,2; Email Address: adate@cdc.gov Kyaw, Moe H. 3 Rue, Alison M. 3 Klahn, Julie 4 Obrecht, LeAnn 4 Krohn, Terry 5 Rowland, Josh 6 Rubin, Steve 7 Safranek, Thomas J. 2 Bellini, William J. 3 Dayan, Gustavo H. 3; Affiliation: 1: Epidemic Intelligence Service, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Nebraska Health and Human Services System, Lincoln, Nebraska 3: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 4: University of Nebraska at Kearney 5: Two Rivers Public Health Department, Kearney 6: Nebraska Public Health Laboratory, University of Nebraska Medical Center, Omaha 7: Food and Drug Administration, Bethesda, Maryland; Source Info: 6/15/2008, Vol. 197 Issue 12, p1662; Subject Term: MUMPS; Subject Term: PAROTID glands -- Diseases; Subject Term: PAROTITIS; Subject Term: IMMUNIZATION; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: PREVENTIVE medicine; Subject Term: VIRUS diseases; Subject Term: MEDICAL virology; Subject Term: ENZYME-linked immunosorbent assay; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/588197
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wright, Jennifer G.
AU - Jung, Sherry
AU - Holman, Robert C.
AU - Marano, Nina N.
AU - McQuiston, Jennifer H.
T1 - Infection control practices and zoonotic disease risks among veterinarians in the United States.
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
Y1 - 2008/06/15/
VL - 232
IS - 12
M3 - Article
SP - 1863
EP - 1872
SN - 00031488
AB - Objective—To assess the knowledge and use of infection control practices (lCPs) among US veterinarians. Design—Anonymous mail-out population survey. Procedures—In 2005 a questionnaire was mailed to US small animal, large animal, and equine veterinarians who were randomly selected from the AVMA membership to assess precaution awareness (PA) and veterinarians' perceptions of zoonotic disease risks. Respondents were assigned a PA score (0 to 4) on the basis of their responses (higher scores representing higher stringency of ICPs); within a practice type, respondents' scores were categorized as being within the upper 25% or lower 75% of scores (high and low PA ranking, respectively). Characteristics associated with low PA rankings were assessed. Results—Generally, respondents did not engage in protective behaviors or use personal protective equipment considered appropriate to protect against zoonotic disease transmission. Small animal and equine veterinarians employed in practices that had no written infection control policy were significantly more likely to have low PA ranking. Male gender was associated with low PA ranking among small animal and large animal veterinarians; equine practitioners not working in a teaching or referral hospital were more likely to have low PA ranking than equine practitioners working in such institutions. Conclusions and Clinical Relevance-Results indicated that most US veterinarians are not aware of appropriate personal protective equipment use and do not engage in practices that may help reduce zoonotic disease transmission. Gender differences may influence personal choices for ICPs. Provision of information and training on ICPs and establishment of written infection control policies could be effective means of improving ICPs in veterinary practices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Veterinary Medical Association is the property of American Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ZOONOSES
KW - VETERINARIANS
KW - INFECTION
KW - PREVENTIVE medicine
KW - UNITED States
N1 - Accession Number: 32632568; Wright, Jennifer G. 1,2 Jung, Sherry 3,4 Holman, Robert C. 1 Marano, Nina N. 1 McQuiston, Jennifer H. 1,3; Affiliation: 1: Centers for Disease Control and Prevention, Coordinating Center for Infectious Diseases, 1600 Clifton Rd, Atlanta, GA 30333 2: US Public Health Service, Rollins School of Public Health, Emory University, Atlanta, GA 30322 3: Epidemiology Department, Rollins School of Public Health, Emory University, Atlanta, GA 30322 4: School of Veterinary Medicine, University of California, Davis, CA 95616; Source Info: Jun2008, Vol. 232 Issue 12, p1863; Subject Term: ZOONOSES; Subject Term: VETERINARIANS; Subject Term: INFECTION; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woo, Sun Wook
AU - Lee, Sung Hee
AU - Ko, Geonil
AU - Kim, Youn-Chul
AU - Sohn, Dong Hwan
T1 - Isoliquiritigenin Inhibits Cell Proliferation by a Heme Oxygenase-Dependent Pathway in Rat Hepatic Stellate Cells.
JO - Planta Medica
JF - Planta Medica
Y1 - 2008/06/15/
VL - 74
IS - 8
M3 - Article
SP - 834
EP - 839
SN - 00320943
AB - We evaluated whether the antiproliferative effects of isoliquiritigenin (ISL) on rat hepatic stellate cells (HSCs) are related to the induction of heme oxygenase 1 (HO-1) expression. ISL significantly inhibited serum- or growth factor-induced HSC proliferation. The inhibition of platelet-derived growth factor (PDGF)-induced proliferation by ISL was associated with the mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-p70S6K pathways. ISL induced the expression of HO-1 in HSCs. Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1. These data suggest that HO-1 expression is responsible for the antiproliferative effect of ISL on HSCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Planta Medica is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dalbergia odorifera T. Chen
KW - heme oxygenase 1
KW - hepatic stellate cell
KW - isoliquiritigenin
KW - Leguminosae
KW - mitogen-activated protein kinase
N1 - Accession Number: 95327995; Woo, Sun Wook 1 Lee, Sung Hee 2 Ko, Geonil 2 Kim, Youn-Chul 2 Sohn, Dong Hwan 2; Affiliation: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea 2: Department of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk, South Korea; Source Info: 2008, Vol. 74 Issue 8, p834; Author-Supplied Keyword: Dalbergia odorifera T. Chen; Author-Supplied Keyword: heme oxygenase 1; Author-Supplied Keyword: hepatic stellate cell; Author-Supplied Keyword: isoliquiritigenin; Author-Supplied Keyword: Leguminosae; Author-Supplied Keyword: mitogen-activated protein kinase; Number of Pages: 6p; Document Type: Article
L3 - 10.1055/s-2008-1074555
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Clark, Rebecca L.
AU - King, Rosalind Berkowitz
T1 - Social and Economic Aspects of Immigration.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2008/06/17/
VL - 1136
M3 - Article
SP - 289
EP - 297
SN - 00778923
AB - The absolute size of the foreign-born U.S. population is at a historical high, but neither the share of the population that is foreign born nor the share of children in immigrant families is high compared with the beginning of the 20th century. While poverty rates for immigrants and children in immigrant families are substantial, poverty is concentrated among certain groups, particularly Hispanics and blacks, non-citizens, and recent arrivals. The general economic well-being of immigrants improves with the move to the United States and as time in the United States increases. However, immigrants remain disadvantaged in terms of health insurance coverage. The economic situation of children in immigrant families has declined since the late 1960s, despite the high labor force participation of immigrant men and the lower prevalence of single-parent households among immigrant families. Still, children in immigrant families are at least as healthy as children in native families and are less likely to engage in risky behaviors. With socioeconomic factors taken into account, children in immigrant families do as well as other children in school. Analyses of the socioeconomic well-being of immigrants have been hampered by lack of information in major data sets about legal status and about the visa status of legally present immigrants, as well as by limited availability of longitudinal data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMIGRATION & immigration
KW - IMMIGRANTS
KW - POVERTY
KW - SINGLE parents
KW - SOCIOECONOMIC factors
KW - HEALTH insurance
KW - HOUSEHOLDS
KW - MEDICAL care
KW - UNITED States
KW - children of immigrants
KW - immigrants
KW - legal immigrants
KW - poverty
KW - socioeconomic status
N1 - Accession Number: 32677479; Clark, Rebecca L. 1,2; Email Address: rclark@mail.nih.gov King, Rosalind Berkowitz 1,2; Affiliation: 1: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814-9692, USA. 2: United States Department of Health and Human Services, Washington, DC 20201, USA.; Source Info: Jun2008, Vol. 1136, p289; Subject Term: EMIGRATION & immigration; Subject Term: IMMIGRANTS; Subject Term: POVERTY; Subject Term: SINGLE parents; Subject Term: SOCIOECONOMIC factors; Subject Term: HEALTH insurance; Subject Term: HOUSEHOLDS; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: children of immigrants; Author-Supplied Keyword: immigrants; Author-Supplied Keyword: legal immigrants; Author-Supplied Keyword: poverty; Author-Supplied Keyword: socioeconomic status; NAICS/Industry Codes: 814110 Private Households; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 9p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1196/annals.1425.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alexandra M. M. Antunes
AU - M. Matilde Marques
AU - Mariana P. Duarte
AU - Pedro P. Santos
AU - Gonçalo Gamboa da Costa
AU - Thomas M. Heinze
AU - Frederick A. Beland
T1 - Synthesis and Characterization of DNA Adducts from the HIV Reverse Transcriptase Inhibitor Nevirapine.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2008/06/17/
VL - 21
IS - 7
M3 - Article
SP - 1443
EP - 1456
SN - 0893228X
AB - Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used against the human immunodeficiency virus type 1 (HIV-1), mostly to prevent mother-to-child HIV transmission in developing countries. One of the limitations of nevirapine use is severe hepatotoxicity, which raises concerns about its administration, particularly in the perinatal and pediatric settings. Nevirapine metabolism involves oxidation of the 4-methyl substituent to 12-hydroxy-NVP and the formation of phenolic derivatives. Further metabolism of 12-hydroxy-NVP by phase II esterification may produce electrophilic derivatives capable of reacting with DNA to yield covalent adducts, which could potentially be involved in the initiation of mutagenic and carcinogenic events. In the present study, we have investigated the reactivity of the synthetic model electrophile, 12-mesyloxy-NVP, toward 2′-deoxynucleosides and DNA. Parallel synthetic studies were conducted with 12-bromo-NVP and 3′,5′- O-bis( tert-butyldimethylsilyl)-2′-deoxynucleosides, using palladium(0) catalysis. Multiple adducts from deoxyguanosine, deoxyadenosine, and deoxycytidine were isolated in the reactions with 12-mesyloxy-NVP and characterized by NMR and MS. The adduct structures consistently involved binding through C12 of NVP and N7 or N9 of deoxyguanosine; N1, N3, or N9 of deoxyadenosine; and N3 of deoxycytidine. Reactions conducted under palladium(0) catalysis yielded adducts through O6and N1 of deoxyguanosine, N1 of deoxyadenosine, and N3 of deoxycytidine. At least seven deoxynucleoside-NVP adducts were present in DNA reacted with 12-mesyloxy-NVP and enzymatically hydrolyzed. Four of these adducts were identified as 12-(deoxyadenosin-N1-yl)nevirapine, 12-(deoxycytidin-N3-yl)nevirapine, 12-(deoxyguanosin- O6-yl)nevirapine, and 12-(deoxyadenosin- N6-yl)nevirapine. One depurinating adduct, 12-(guanin-N7-yl)nevirapine, was identified in the thermal neutral DNA hydrolysate. If formed in vivo, some of these adducts would have considerable mutagenic potential. Our results thus suggest that NVP metabolism to 12-hydroxy-NVP may be a factor in NVP hepatocarcinogenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Research in Toxicology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA adducts
KW - HIV infections -- Transmission
KW - TRANSCRIPTION factors
KW - HEPATOTOXICOLOGY
N1 - Accession Number: 33940615; Alexandra M. M. Antunes 1 M. Matilde Marques 1 Mariana P. Duarte 1 Pedro P. Santos 1 Gonçalo Gamboa da Costa 1 Thomas M. Heinze 1 Frederick A. Beland 1; Affiliation: 1: REQUIMTE/CQFB, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal, Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, 1049-001 Lisboa, Portugal, and Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; Source Info: Jun2008, Vol. 21 Issue 7, p1443; Subject Term: DNA adducts; Subject Term: HIV infections -- Transmission; Subject Term: TRANSCRIPTION factors; Subject Term: HEPATOTOXICOLOGY; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luginbuhl, R. C.
AU - Jackson, L. L.
AU - Castillo, D. N.
AU - Loringer, K. A.
T1 - Heat-Related Deaths Among Crop Workers -- United States, 1992-2006.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/06/20/
VL - 57
IS - 24
M3 - Article
SP - 649
EP - 653
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - This article discusses a report on the prevalence of heat-related deaths among crop production workers in the U.S. from 1992 to 2006. The report found that 423 workers in agricultural and nonagricultural industries were reported to have died from exposure to environmental heat during the period. It also revealed that the heat-related average annual death rate for these crop workers was 0.39 per 100,000 workers, compared with 0.02 for all U.S. civilian workers.
KW - AGRICULTURAL laborers
KW - MORTALITY -- Statistics
KW - HIGH temperatures
KW - AGRICULTURAL industries -- Employees
KW - UNITED States
N1 - Accession Number: 32818289; Luginbuhl, R. C. Jackson, L. L. 1 Castillo, D. N. 1 Loringer, K. A.; Affiliation: 1: Div of Safety Research, National Institute for Occupational Safety and Health; Source Info: 6/20/2008, Vol. 57 Issue 24, p649; Subject Term: AGRICULTURAL laborers; Subject Term: MORTALITY -- Statistics; Subject Term: HIGH temperatures; Subject Term: AGRICULTURAL industries -- Employees; Subject Term: UNITED States; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gait, R.
AU - Soutar, R. H.
AU - Hanson, M.
AU - Fraser, C.
AU - Chalmers, R.
T1 - Outbreak of cryptosporidiosis among veterinary students.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2008/06/28/
VL - 162
IS - 26
M3 - Article
SP - 843
EP - 845
SN - 00424900
AB - In January 2007, six veterinary students became infected with CryptosporidIum species, and records indicated that another student had been diagnosed in November 2006. It was established that the seven students had worked with cattle from the same farm. Microbiological tests indicated that they were infected with Cryptosporidlum parvum. Subtyping by sequence analysis indicated a common source of infection for five of the students, but there was insufficient material to type the other two samples. Investigations indicated that the outbreak was caused by a lapse in hygiene, particularly handwashing. on a farm with enzootic Cparvum in calves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Veterinary Record: Journal of the British Veterinary Association is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIOSIS
KW - CRYPTOSPORIDIUM
KW - WATERBORNE infection
KW - COCCIDIOSIS
KW - VETERINARY students
KW - HEALTH occupations students
KW - VETERINARY medicine -- Study & teaching
N1 - Accession Number: 33244074; Gait, R. 1 Soutar, R. H. 2 Hanson, M. 3 Fraser, C. 1 Chalmers, R. 4; Affiliation: 1: NHS Lothian, Deaconess House, 148 Pleasance, Edinburgh EH8 9RS 2: Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EI-19 IQH 3: Lothian University Hospitals Trust, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU 4: UK Cryptosporidium Reference Unit, National Public Health Service, Microbiology Swansea, Singleton Hospital, Swansea SA2 8QA; Source Info: 6/28/2008, Vol. 162 Issue 26, p843; Subject Term: CRYPTOSPORIDIOSIS; Subject Term: CRYPTOSPORIDIUM; Subject Term: WATERBORNE infection; Subject Term: COCCIDIOSIS; Subject Term: VETERINARY students; Subject Term: HEALTH occupations students; Subject Term: VETERINARY medicine -- Study & teaching; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 3p; Illustrations: 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105659192
T1 - Annual report on health care for children and youth in the United States: focus on injury-related emergency department utilization and expenditures.
AU - Owens PL
AU - Zodet MW
AU - Berdahl T
AU - Dougherty D
AU - McCormick MC
AU - Simpson LA
Y1 - 2008/07//Jul/Aug2008
N1 - Accession Number: 105659192. Language: English. Entry Date: 20081003. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 101089367.
KW - Emergency Service -- Economics
KW - Emergency Service -- Utilization
KW - Health Care Costs -- Statistics and Numerical Data
KW - Pediatrics -- Economics
KW - Wounds and Injuries -- Economics
KW - Wounds and Injuries -- Epidemiology
KW - Adolescence
KW - Child
KW - Child, Preschool
KW - Emergency Service -- Statistics and Numerical Data
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Insurance, Health -- Statistics and Numerical Data
KW - Male
KW - Medicaid -- Statistics and Numerical Data
KW - Medically Uninsured -- Statistics and Numerical Data
KW - Patient Admission -- Statistics and Numerical Data
KW - Pediatrics -- Statistics and Numerical Data
KW - Retrospective Design
KW - Socioeconomic Factors
KW - Trauma Severity Indices
KW - United States
KW - Human
SP - 219
EP - 240.e17
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 8
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - OBJECTIVE: To examine state differences in children's utilization of injury-related emergency department (ED) care across 14 states, benchmarking aggregate state estimates against national expenditure estimates for outpatient injury-related ED care. METHODS: A retrospective analysis was performed using the 2003 State Emergency Department Databases and State Inpatient Databases from the Healthcare Cost and Utilization Project and data from the Medical Expenditure Panel Survey. Pediatric ED visits with any injury International Classification of Diseases Ninth Version Clinical Modification (ICD-9-CM) diagnosis code were selected. The Barell Injury Diagnosis Matrix, ICDMAP-90 software, and the Trauma Information Exchange Program data were used to classify injuries, produce injury severity scores, and examine utilization in trauma centers. Aggregate and state-specific descriptive analyses compared differences in patient and injury characteristics and admission status by age, severity of injury, and expected payer. RESULTS: Over 1.5 million or nearly one-third of ED visits were for pediatric injuries in the 14 states studied. Nationally, 5.4% of children had an injury-related ED visit, and approximately $2.3 billion was spent on outpatient injury-related ED visits in 2003. The pattern of injury-related ED visit care varied considerably by state. For example, injury-related ED visit rates ranged from 63.3 to 164.4 per 1000 children. Infants, adolescents, children from very low income communities, and children from nonmetropolitan and nonmicropolitan areas were more likely to have an injury-related ED visit than their peers. Although patient characteristics were fairly consistent across states, admission rates and expected source of payment for injury-related ED visits varied considerably by state. Hospital admission rates ranged from 1.5% to 4.4% of injury-related ED visits and expected payer estimates ranged from 37.1% to 71.0% of visits billed to private insurance, 17.9% to 47.0% billed to Medicaid, and 2.1% to 10.4% billed as uninsured. CONCLUSIONS: This study suggests that injuries account for a significant portion of pediatric ED visits. There is substantial variation in ED use and hospital admissions for injured children across states and payers. This variation suggests that there are several opportunities for improvement in emergency care for children. To better understand the underlying reason for the variation, multivariate and hypothesis-driven research should focus on the nature and outcomes of injury-related ED care in the context of small area practice patterns and state programs, policies, and care system characteristics.
SN - 1530-1567
AD - Agency for Healthcare, Research and Quality, Department of Health and Human Services, Rockville, Maryland 20850, USA. Pamela.Owens@ahrq.hhs.gov
U2 - PMID: 18644545.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105655274
T1 - New patient safety organizations lower roadblocks to medical error reporting.
AU - Clancy CM
Y1 - 2008/07//Jul/Aug2008
N1 - Accession Number: 105655274. Language: English. Entry Date: 20081003. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Patient Safety
KW - Quality Improvement
KW - Adverse Health Care Event
KW - Health Care Errors -- Evaluation
KW - Liability, Legal
KW - Patient Safety -- Legislation and Jurisprudence -- United States
KW - Privacy and Confidentiality
KW - United States
SP - 318
EP - 321
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 23
IS - 4
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 18658105.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Keener, William K.
AU - Rivera, Victor R.
AU - Cho, Chung Y.
AU - Hale, Martha L.
AU - Garber, Eric A.E.
AU - Poli, Mark A.
T1 - Identification of the RNA N-glycosidase activity of ricin in castor bean extracts by an electrochemiluminescence-based assay
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2008/07//
VL - 378
IS - 1
M3 - Article
SP - 87
EP - 89
SN - 00032697
AB - Abstract: A simple electrochemiluminescence-based assay for RNA N-glycosidase activity has been modified to permit its use with authentic extracts of Ricinus communis (castor beans) and Abrus precatorius (jequirity seeds)—the natural sources of ricin and abrin. Modifications include the addition of an RNase inactivator to the reaction mixture, elimination of a signal-enhancing monoclonal antibody, and optimization of the incubation temperature. Concurrent testing with two substrates provides a diagnostic tool enabling castor bean toxins to be differentiated from a larger selection of N-glycosidase toxins than was previously examined. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - METABOLITES
KW - TOXINS
KW - MOLECULAR cloning
N1 - Accession Number: 32177787; Keener, William K. 1; Email Address: william.keener@us.army.mil Rivera, Victor R. 1 Cho, Chung Y. 2 Hale, Martha L. 1 Garber, Eric A.E. 2 Poli, Mark A. 1; Email Address: mark.poli@us.army.mil; Affiliation: 1: U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA 2: U.S. Food and Drug Administration, College Park, MD 20740, USA; Source Info: Jul2008, Vol. 378 Issue 1, p87; Subject Term: NUCLEIC acids; Subject Term: METABOLITES; Subject Term: TOXINS; Subject Term: MOLECULAR cloning; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.ab.2008.03.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105774349
T1 - Screening for asymptomatic bacteriuria in adults: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement.
AU - Lin K
AU - Fajardo K
Y1 - 2008/07//7/1/2008
N1 - Accession Number: 105774349. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20080725. Revision Date: 20150711. Publication Type: Journal Article. Commentary: Summaries for patients. Screening for asymptomatic bacteriuria in adults: U.S. Preventive Services Task Force recommendations. (ANN INTERN MED) 7/1/2008; 149 (1): I-37. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Bacteriuria -- Diagnosis
KW - Health Screening -- Adverse Effects
KW - Adult
KW - Bacteriuria -- Drug Therapy
KW - Female
KW - Male
KW - Pregnancy Complications, Infectious -- Diagnosis
KW - Pregnancy Complications, Infectious -- Drug Therapy
KW - Pregnancy
SP - W20
EP - 4
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 149
IS - 1
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Asymptomatic bacteriuria is common, and screening for this condition in pregnant women is a well-established, evidence-based standard of current medical practice. Screening other groups of adults has not been shown to improve outcomes. PURPOSE: To review new and substantial evidence on screening for asymptomatic bacteriuria, to support the work of the U.S. Preventive Services Task Force. DATA SOURCES: English-language studies of adults (age >18 years) indexed in PubMed and the Cochrane Library and published from 1 January 2002 through 30 April 2007. STUDY SELECTION: For benefits of screening or treatment for screened populations, systematic reviews; meta-analyses; and randomized, controlled trials were included. For harms of screening, systematic reviews; meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and case series of large multisite databases were included. Two reviewers independently reviewed titles, abstracts, and full articles for inclusion. DATA EXTRACTION: Two reviewers extracted data from studies on benefits of screening and treatment (including decreases in the incidence of adverse maternal and fetal outcomes, symptomatic urinary tract infections, hypertension, and renal function decline). DATA SYNTHESIS: An updated Cochrane systematic review of 14 randomized, controlled trials of treatment supports screening for asymptomatic bacteriuria in pregnant women. A randomized, controlled trial and a prospective cohort study show that screening nonpregnant women with diabetes for asymptomatic bacteriuria is unlikely to produce benefits. No new evidence on screening men for asymptomatic bacteriuria or on harms of screening was found. LIMITATION: The focused search strategy may have missed some smaller studies on the benefits and harms of screening for asymptomatic bacteriuria. CONCLUSION: The available evidence continues to support screening for asymptomatic bacteriuria in pregnant women, but not in other groups of adults.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. kenneth.lin@ahrq.hhs.gov
U2 - PMID: 18591632.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105792580
T1 - Improving the safety and quality of care transitions.
AU - Clancy CM
Y1 - 2008/07//
N1 - Accession Number: 105792580. Language: English. Entry Date: 20080822. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care; Quality Assurance. NLM UID: 0372403.
KW - Continuity of Patient Care
KW - Health Care Errors -- Prevention and Control
KW - Patient Safety
KW - Transfer, Intrahospital
KW - Communication
KW - Joint Commission
KW - Medication Errors
KW - Quality Improvement
KW - United States Agency for Healthcare Research and Quality
SP - 111
EP - 113
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 88
IS - 1
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 18603039.
DO - 10.1016/j.aorn.2008.06.009
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - William F. Pearman
AU - S. Michael Angel
AU - John L. Ferry
AU - Sherwood Hall
T1 - Characterization of the Ag Mediated Surface-Enhanced Raman Spectroscopy of Saxitoxin.
JO - Applied Spectroscopy
JF - Applied Spectroscopy
Y1 - 2008/07//
VL - 62
IS - 7
M3 - Article
SP - 727
EP - 732
SN - 00037028
AB - The rapid detection and quantification of saxitoxin (STX) is reported using surface-enhanced Raman spectroscopy (SERS) with a colloidal hydrosol of silver nanoparticles. Under the conditions of our experiments, the limit of detection (LD) for STX using SERS is 3 nM, with a limit of quantification (LQ) of 20 nM. It is shown that the SERS method is rapid, with spectra being collected in as little as 5 seconds total integration time for a 40 nM STX sample. In order to improve the signal-to-noise ratio, SERS spectra were generally collected with a total integration time of 1 minute (6 accumulations of 10 seconds each), with no need for extensive sample work-up or substrate preparation. Based on these results, the SERS technique shows great promise for the future detection and quantification of STX molecules in aqueous solutions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Spectroscopy is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPECTRUM analysis
KW - PRECIOUS metals
KW - RAMAN spectroscopy
KW - ALGAL toxins
N1 - Accession Number: 33199850; William F. Pearman 1 S. Michael Angel 1 John L. Ferry 1 Sherwood Hall 2; Affiliation: 1: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 2: Food and Drug Administration, HFS-716, CHCB DBC ORS CFSAN, College Park, Maryland 20740; Source Info: Jul2008, Vol. 62 Issue 7, p727; Subject Term: SPECTRUM analysis; Subject Term: PRECIOUS metals; Subject Term: RAMAN spectroscopy; Subject Term: ALGAL toxins; NAICS/Industry Codes: 212220 Gold and silver ore mining; NAICS/Industry Codes: 212221 Gold Ore Mining; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423940 Jewelry, Watch, Precious Stone, and Precious Metal Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105812757
T1 - Recently approved pharmaceutical agents.
AU - Kwitkowski V
AU - Ryan Q
AU - Cohen MH
AU - Dmytrijuk A
Y1 - 2008/07//2008 Jul
N1 - Accession Number: 105812757. Language: English. Entry Date: 20080912. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care.
KW - Drug Approval
KW - United States Food and Drug Administration -- United States
KW - Angiogenesis Inhibitors -- Therapeutic Use
KW - Antibodies, Monoclonal -- Therapeutic Use
KW - Antineoplastic Agents -- Therapeutic Use
KW - Breast Neoplasms -- Drug Therapy
KW - Drug Therapy, Combination
KW - Hemolysis -- Prevention and Control
KW - Leukemia, Lymphocytic, Chronic -- Drug Therapy
KW - Paclitaxel -- Therapeutic Use
KW - Proteinuria -- Drug Therapy
KW - United States
SP - 40
EP - 42
JO - ASCO News & Forum
JF - ASCO News & Forum
JA - ASCO NEWS FORUM
VL - 3
IS - 3
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
SN - 1931-7646
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hotchkiss, Charlotte E.
AU - Weis, Connie
AU - Blaydes, Betty
AU - Newbold, Retha
AU - Delclos, K. Barry
T1 - Multigenerational exposure to ethinyl estradiol affects bone geometry, but not bone mineral density in rats
JO - BONE
JF - BONE
Y1 - 2008/07//
VL - 43
IS - 1
M3 - Article
SP - 110
EP - 118
SN - 87563282
AB - Abstract: Estrogenic compounds are known to prevent bone loss in ovariectomized adult rats; however, their effects on bone in developing and reproductively-intact rats are less well-understood. In a large multigenerational experiment 0, 2, 10, or 50 ppb ethinyl estradiol (EE) in the diet was fed to intact male and female rats from conception until either weaning, postnatal day 140, or continuously for 2 years. Vertebrae (lumbar and caudal) and femurs were collected from subsets of these animals at necropsy at 48 days, 70 days, 140 days, or 2 years of age and subjected to dual-energy X-ray absorptiometry (DXA) scanning to measure bone mineral density (BMD), bone mineral content (BMC), and bone area. In addition, the length, cross-sectional area, marrow area, and cortical bone area of the femurs were measured directly in all animals at PND 140 and 2 years. Continuous dietary intake of 50 ppb EE decreased body weight by 8–27%. BMD adjusted for body weight was not affected by EE, with the exception of an increase in the caudal vertebrae in males treated with 50 ppb EE. In female rats, continuous treatment with 50 ppb EE decreased length and cross-sectional area of the femur. The length of the femur was decreased in the first two generations following institution of a phytoestrogen-free diet at the initiation of the study in all animals, including controls, but returned to the original length by the third or fourth generation. The cross-sectional area of the femur also varied by generation. In conclusion, a high dose of EE throughout the lifespan resulted in decreased bone size in females, which could reduce the force required to break the bone. Furthermore, dietary changes may have epigenetic effects which persist for multiple generations. [Copyright &y& Elsevier]
AB - Copyright of BONE is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTROGEN
KW - BONE
KW - ETHINYL estradiol
KW - FEMUR
KW - BODY weight
KW - Bone development
KW - bone formation rate, bone surface referent ( BFR_BS )
KW - bone formation rate, bone volume referent ( BFR_BV )
KW - bone formation rate, tissue volume referent ( BFR_TV )
KW - bone mineral content ( BMC )
KW - Bone mineral density
KW - bone mineral density ( BMD )
KW - bone surface relative to bone volume ( BS_BV )
KW - bone volume as percent of total tissue volume ( BV_TV )
KW - Endocrine disruptors
KW - Estrogen
KW - mineral apposition rate ( MAR )
KW - mineralizing surface relative to bone surface ( MS_BS )
KW - Rat
KW - trabecular number ( Tb_N )
KW - trabecular spacing ( Tb_Sp )
KW - trabecular thickness ( Tb_Th )
N1 - Accession Number: 32644492; Hotchkiss, Charlotte E. 1; Email Address: chotchki@wanprc.org Weis, Connie 1 Blaydes, Betty 1 Newbold, Retha 2 Delclos, K. Barry 1; Affiliation: 1: The National Center for Toxicological Research, Jefferson, AR, USA 2: Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Source Info: Jul2008, Vol. 43 Issue 1, p110; Subject Term: ESTROGEN; Subject Term: BONE; Subject Term: ETHINYL estradiol; Subject Term: FEMUR; Subject Term: BODY weight; Author-Supplied Keyword: Bone development; Author-Supplied Keyword: bone formation rate, bone surface referent ( BFR_BS ); Author-Supplied Keyword: bone formation rate, bone volume referent ( BFR_BV ); Author-Supplied Keyword: bone formation rate, tissue volume referent ( BFR_TV ); Author-Supplied Keyword: bone mineral content ( BMC ); Author-Supplied Keyword: Bone mineral density; Author-Supplied Keyword: bone mineral density ( BMD ); Author-Supplied Keyword: bone surface relative to bone volume ( BS_BV ); Author-Supplied Keyword: bone volume as percent of total tissue volume ( BV_TV ); Author-Supplied Keyword: Endocrine disruptors; Author-Supplied Keyword: Estrogen; Author-Supplied Keyword: mineral apposition rate ( MAR ); Author-Supplied Keyword: mineralizing surface relative to bone surface ( MS_BS ); Author-Supplied Keyword: Rat; Author-Supplied Keyword: trabecular number ( Tb_N ); Author-Supplied Keyword: trabecular spacing ( Tb_Sp ); Author-Supplied Keyword: trabecular thickness ( Tb_Th ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bone.2008.03.016
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DB - aph
ER -
TY - JOUR
AU - Rabin, R. L.
AU - Levinson, A. I.
T1 - The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature.
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
Y1 - 2008/07//
VL - 153
IS - 1
M3 - Article
SP - 19
EP - 30
PB - Wiley-Blackwell
SN - 00099104
AB - There has been considerable interest in defining the relationship between the expression of allergic and autoimmune diseases in populations of patients. Are patients with autoimmune disease ‘protected’ from developing allergic (immunoglobulin E-mediated) diseases? Does the establishment of an atopic phenotype reduce the risk of the subsequent development of autoimmune diseases? Although there are clinical studies addressing this question, methodological problems, particularly in identification of atopic subjects, limits their usefulness. Moreover, an immune-based explanation of the observed epidemiological findings has relied on a paradigm that is currently undergoing increased scrutiny and modification to include newly defined effector cell subsets and the interaction between genetic and environmental factors, such as early endotoxin or mycobacterial exposure. To address this question, we reviewed a series of clinical reports that addressed coincidence or co-prevalence of atopy with four autoimmune diseases: psoriasis, rheumatoid arthritis, multiple sclerosis and type I diabetes mellitus. We present a model whereby active T helper type 1 (Th1) inflammation may suppress the development of atopy, and atopy may suppress the severity but not necessarily the onset of autoimmunity, and then discuss our model in the context of mechanisms of adaptive immunity with particular reference to the Th1/Th2 paradigms. Because the ultimate goal is to ameliorate or cure these diseases, our discussion may help to predict or interpret unexpected consequences of novel therapeutic agents used to target autoimmune or atopic diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical & Experimental Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTOIMMUNITY
KW - ATOPY
KW - ALLERGY -- Diagnosis
KW - IMMUNOLOGIC diseases
KW - RHEUMATOID arthritis
KW - DIABETES
KW - allergy
KW - autoimmunity
KW - multiple sclerosis
KW - rheumatoid arthritis
KW - T cell subsets
KW - type I diabetes mellitus
N1 - Accession Number: 32538332; Rabin, R. L. 1; Email Address: rrabin@helix.nih.gov Levinson, A. I. 2; Affiliation: 1: Center for Biologics Evaluation and Research, USFDA, Bethesda, MD 2: Pulmonary Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Source Info: Jul2008, Vol. 153 Issue 1, p19; Subject Term: AUTOIMMUNITY; Subject Term: ATOPY; Subject Term: ALLERGY -- Diagnosis; Subject Term: IMMUNOLOGIC diseases; Subject Term: RHEUMATOID arthritis; Subject Term: DIABETES; Author-Supplied Keyword: allergy; Author-Supplied Keyword: autoimmunity; Author-Supplied Keyword: multiple sclerosis; Author-Supplied Keyword: rheumatoid arthritis; Author-Supplied Keyword: T cell subsets; Author-Supplied Keyword: type I diabetes mellitus; Number of Pages: 12p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1111/j.1365-2249.2008.03679.x
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DB - aph
ER -
TY - JOUR
ID - 105656955
T1 - Lower extremity regional anesthesia with the low sciatic nerve block.
AU - Goss K
Y1 - 2008/07//2008 Jul
N1 - Accession Number: 105656955. Language: English. Entry Date: 20081003. Revision Date: 20150820. Publication Type: Journal Article; pictorial; review. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pain and Pain Management; Perioperative Care. NLM UID: 8604974.
KW - Nerve Block -- Methods
KW - Sciatica -- Surgery
KW - Bupivacaine -- Administration and Dosage
KW - Bupivacaine -- Pharmacodynamics
SP - 431
EP - 441
JO - Clinics in Podiatric Medicine & Surgery
JF - Clinics in Podiatric Medicine & Surgery
JA - CLIN PODIATR MED SURG
VL - 25
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Regional anesthesia with local anesthetics is an important component of the perioperative pain management algorithm in the context of lower extremity orthopedic surgery. These techniques have proved to be consistent and effective in minimizing postoperative pain and narcotic usage, and in reducing the morbidity associated with lower extremity surgery. The mechanisms of local anesthetic agents as they relate to acute surgical pain are reviewed in this article, with an emphasis on the low sciatic nerve block. Administration techniques and the clinical experience of the author with this blockade are discussed. Copyright © 2008 by Elsevier Inc.
SN - 0891-8422
AD - Department of Surgery, Northern Navajo Medical Center, Indian Health Service, Shiprock, NM, USA.
U2 - PMID: 18486853.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Humphrey, Brooke D.
AU - Kirsch, Sandra
AU - Morris, Diane
T1 - Molecular cloning and characterization of the chicken cationic amino acid transporter-2 gene
JO - Comparative Biochemistry & Physiology Part B
JF - Comparative Biochemistry & Physiology Part B
Y1 - 2008/07//
VL - 150
IS - 3
M3 - Article
SP - 301
EP - 311
SN - 10964959
AB - Abstract: The system y+ cationic amino acid transporters (CATs) play an important role in the regulation of lysine and arginine utilization. We have characterized the genomic organization and tissue transcription of the chicken CAT-2 (cCAT-2) isoforms from pectoralis muscle. The primary cCAT-2 transcript is alternatively spliced within the same position of the mRNA to produce cCAT-2A and cCAT-2B isoforms that share high nucleotide homology with their mammalian counterparts. We also identified a novel third CAT-2 isoform, cCAT-2C. This isoform contains a premature termination codon and studies in the chicken LMH cell line show that cCAT-2C mRNA is degraded by the nonsense-mediated mRNA decay pathway. All three cCAT-2 isoforms are transcribed in liver, pectoralis, gastrocnemius and heart. Chicken cCAT-2A was the predominant cCAT-2 isoform in liver, pectoralis and gastrocnemius. Analysis of the 5′-untranslated region of cCAT-2 identified multiple cCAT-2 promoters. Chicken CAT-2 promoter usage was tissue dependent and was not responsible for cCAT-2 isoform production. Analysis of genomic sequence upstream cCAT-2 promoter regions revealed binding sites for transcription factors involved in amino acid sensing, hormone signaling and immune function. These results provide insight into the role of the cCAT-2 gene and its regulation of lysine and arginine utilization in aves. [Copyright &y& Elsevier]
AB - Copyright of Comparative Biochemistry & Physiology Part B is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINO acids
KW - LYSINE
KW - ARGININE
KW - PECTORALIS muscle
KW - NUCLEOTIDES
KW - Arginine
KW - Chicken
KW - Lysine
KW - Nitric oxide
KW - Pectoralis
KW - System y+
KW - Transport
N1 - Accession Number: 32497090; Humphrey, Brooke D. 1,2; Email Address: bdhumphr@calpoly.edu Kirsch, Sandra 1,3 Morris, Diane 1,4; Affiliation: 1: Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA 2: Animal Science Department, California Polytechnic State University, 1 Grand Ave, San Luis Obispo, CA 93407, USA 3: Molecular and Cellular Biology, 4112 Plant Sciences Building, University of Maryland, College Park, MD 20742, USA 4: U.S. Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857-0001, USA; Source Info: Jul2008, Vol. 150 Issue 3, p301; Subject Term: AMINO acids; Subject Term: LYSINE; Subject Term: ARGININE; Subject Term: PECTORALIS muscle; Subject Term: NUCLEOTIDES; Author-Supplied Keyword: Arginine; Author-Supplied Keyword: Chicken; Author-Supplied Keyword: Lysine; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: Pectoralis; Author-Supplied Keyword: System y+; Author-Supplied Keyword: Transport; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.cbpb.2008.03.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - García Ortiz, Patricia
AU - Hansen, Steen Honoré
AU - Shah, Vinod P.
AU - Menné, Torkil
AU - Benfeldt, Eva
T1 - The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 2008/07//
VL - 59
IS - 1
M3 - Article
SP - 23
EP - 30
PB - Wiley-Blackwell
SN - 01051873
AB - Background: Determination of drug penetration in diseased skin represents a challenge. Objective: To compare dermal microdialysis and tape-strip sampling of drug penetration in normal skin and skin with irritant dermatitis. Methods: The two methodologies were employed simultaneously in 16 healthy volunteers. Samples were collected in a study of the penetration of a metronidazole cream formulation (Flagyl® 1%) applied to forearm skin in both areas with irritant dermatitis and normal skin. Barrier perturbation and the depth of microdialysis probes were quantified by non-invasive bioengineering methods. Results: Microdialysis showed a significant threefold increase in metronidazole penetration in skin with irritant dermatitis compared with unmodified skin. Conversely, the concentration of metronidazole in tape-strip samples was significantly decreased in irritant dermatitis. Conclusion: The selection of sampling methodology should be based on the skin layer of interest as well as the integrity of the skin barrier. Whenever the dermal tissue is the target for topical treatment, microdialysis sampling should be the method of choice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Inflammation
KW - METRONIDAZOLE
KW - ANTIPARASITIC agents
KW - DERMATOLOGY
KW - PHARMACOKINETICS
KW - irritant dermatitis
KW - metronidazole
KW - microdialysis
KW - tape-strip sampling
KW - topical penetration
KW - topocal penetration
N1 - Accession Number: 32659312; García Ortiz, Patricia 1; Email Address: patriciagarcia@dadlnet.dk Hansen, Steen Honoré 2 Shah, Vinod P. 3 Menné, Torkil 1 Benfeldt, Eva 1; Affiliation: 1: Department of Dermatology, Gentofte Hospital, 2900 Hellerup 2: Department of Pharmaceutics and Analytical Chemistry, Pharmaceutical Faculty, Copenhagen University, 2100 Copenhagen, Denmark 3: Office of Pharmaceutical Science, Food and Drug Administration, Rockville, MD 20857-0001, USA; Source Info: Jul2008, Vol. 59 Issue 1, p23; Subject Term: SKIN -- Inflammation; Subject Term: METRONIDAZOLE; Subject Term: ANTIPARASITIC agents; Subject Term: DERMATOLOGY; Subject Term: PHARMACOKINETICS; Author-Supplied Keyword: irritant dermatitis; Author-Supplied Keyword: metronidazole; Author-Supplied Keyword: microdialysis; Author-Supplied Keyword: tape-strip sampling; Author-Supplied Keyword: topical penetration; Author-Supplied Keyword: topocal penetration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0536.2008.01348.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Collier, Robert J.
AU - Miller, M.A.
AU - McLaughlin, C.L.
AU - Johnson, H.D.
AU - Baile, C.A.
T1 - Effects of recombinant bovine somatotropin (rbST) and season on plasma and milk insulin-like growth factors I (IGF-I) and II (IGF-II) in lactating dairy cows
JO - Domestic Animal Endocrinology
JF - Domestic Animal Endocrinology
Y1 - 2008/07//
VL - 35
IS - 1
M3 - Article
SP - 16
EP - 23
SN - 07397240
AB - Abstract: During two studies, effects of recombinant bovine somatotropin (rbST) on plasma and milk IGF''s in cows adapted to summer (S; 12 cows) or winter (W; 12 cows) conditions were evaluated. Each study consisted of on-farm periods (30 days) followed by climatology chamber periods (CC; 30 days). Cows were given daily injections of rbST, Sometribove, USAN (25mg/day; 6 cows each study) or saline (control; 6 cows each study). During on-farm periods, blood and milk (am and pm) samples were collected once weekly. During CC periods, blood samples were collected every 2 days and milk samples (am and pm) were collected daily. Plasma IGF-I and IGF-II were increased in cows treated with rbST. A pronounced seasonal pattern in basal and rbST-stimulated plasma IGF-I but not IGF-II was detected. Higher basal and rbST-stimulated plasma IGF-I concentrations in S occurred despite large decreases in feed intake and energy balance. Milk IGF-I and IGF-II was not affected by rbST treatment or season. Although milk IGF-I and IGF-II concentrations were unaffected by rbST treatment, total IGF-output increased due to increased milk yield. The observed seasonal patterns in plasma IGF-I may be indicative of seasonal differences in the coupling of the somatotropin-IGF axis. In particular, we failed to detect an uncoupling of the somatotropin-IGF-I axis in S despite an induced negative energy balance during thermal stress. [Copyright &y& Elsevier]
AB - Copyright of Domestic Animal Endocrinology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RECOMBINANT bovine somatotropin
KW - BLOOD plasma
KW - LACTATION
KW - TEMPERATURE -- Physiological effect
KW - Cattle
KW - IGF-I
KW - IGF-II
KW - rbST
KW - Season
N1 - Accession Number: 32556146; Collier, Robert J. 1; Email Address: rcollier@ag.arizona.edu Miller, M.A. 2 McLaughlin, C.L. 3 Johnson, H.D. 4 Baile, C.A. 5; Affiliation: 1: Department of Animal Science, University of Arizona, 204 Shantz Building, PO Box 210038, Tucson, AZ 85721, United States 2: Food and Drug Administration, Rockville, MD, United States 3: Pfizer Company, Kalamazoo, MI, United States 4: University of Missouri, Columbia, MO, United States 5: University of Georgia, Athens, GA, United States; Source Info: Jul2008, Vol. 35 Issue 1, p16; Subject Term: RECOMBINANT bovine somatotropin; Subject Term: BLOOD plasma; Subject Term: LACTATION; Subject Term: TEMPERATURE -- Physiological effect; Author-Supplied Keyword: Cattle; Author-Supplied Keyword: IGF-I; Author-Supplied Keyword: IGF-II; Author-Supplied Keyword: rbST; Author-Supplied Keyword: Season; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.domaniend.2008.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Jinhai
AU - Norcross, Michael
T1 - Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy
JO - Drug Discovery Today
JF - Drug Discovery Today
Y1 - 2008/07//
VL - 13
IS - 13/14
M3 - Article
SP - 625
EP - 632
SN - 13596446
AB - Chemokine receptors control and mediate a diverse array of physiological and pathogenic processes. Many seven transmembrane (TM) G-protein-coupled receptors (GPCRs), including chemokine receptors, exist as homo- or heterodimers. Growing evidence indicates that the dimeric form is the basic functional structure of these receptors. Hetero-dimerization may allow for enhanced or specific functions of receptors and may be essential for receptor activity. Thus, dimers may provide new targets for chemokine receptor-based therapies. Synthetic peptides of TM regions of chemokine receptors may interfere with homologous interactions and inhibit functional activity of the receptors. Therefore, TM peptides and possibly compounds that target dimers and/or signaling of chemokine receptors may have therapeutic applications. [Copyright &y& Elsevier]
AB - Copyright of Drug Discovery Today is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMOKINES
KW - CELL receptors
KW - DIMERS
KW - OLIGOMERS
KW - PEPTIDES
KW - PROTEINS
N1 - Accession Number: 32983700; Wang, Jinhai; Email Address: jinhai.wang@fda.hhs.gov Norcross, Michael 1; Affiliation: 1: Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jul2008, Vol. 13 Issue 13/14, p625; Subject Term: CHEMOKINES; Subject Term: CELL receptors; Subject Term: DIMERS; Subject Term: OLIGOMERS; Subject Term: PEPTIDES; Subject Term: PROTEINS; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.drudis.2008.04.004
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Seung-Ho Kang1, seungho@ewha.ac.kr
AU - Suktae Choi2
T1 - Conditional Exact Tests for Dichotomous Data in the Comparison of Two Treatments With One Control Group.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2008/07//
Y1 - 2008/07//
VL - 42
IS - 4
CP - 4
M3 - Article
SP - 337
EP - 347
SN - 00928615
AB - When we compare two treatments with one control group for dichotomous data whose response rates are expected to be small. Dunnett's test based on the large sample theory is unreliable. Hence, exact tests that are reliable in the cases of either small response rate or small samples need to be developed. In this article, we investigate the exact unconditional powers of the three exact tests (the two-step closed Fisher's exact test. the exact conditional Dunnett test, and the new conditional exact test proposed here). The exact unconditional power is computed based on complete enumeration. In many phase 3 clinical trials, two possible optimal doses from phase 2 clinical trials are expected to be more promising than the control. Therefore, the response rates of two possible optimal doses are greater than that of the control group. In such cases, we show that the new exact test is more powerful than the other two exact tests. [ABSTRACT FROM AUTHOR]
KW - Response rates
KW - Fisher exact test
KW - Statistical hypothesis testing
KW - Clinical trials
KW - Control groups (Research)
KW - Reliability (Personality trait)
KW - 2 x 3 contingency table
KW - Dunnett's test
KW - Exact power
KW - Multiple comparison
KW - Two-step closed Fisher's exact test
N1 - Accession Number: 33206265; Authors: Seung-Ho Kang 1 Email Address: seungho@ewha.ac.kr; Suktae Choi 2; Affiliations: 1: Department of Statistics, Ewha Womans University, Seoul, Korea; 2: US Food and Drug Administration, Silver Spring, Maryland; Subject: Fisher exact test; Subject: Statistical hypothesis testing; Subject: Clinical trials; Subject: Response rates; Subject: Control groups (Research); Subject: Reliability (Personality trait); Author-Supplied Keyword: 2 x 3 contingency table; Author-Supplied Keyword: Dunnett's test; Author-Supplied Keyword: Exact power; Author-Supplied Keyword: Multiple comparison; Author-Supplied Keyword: Two-step closed Fisher's exact test; Number of Pages: 11p; Illustrations: 7 Charts; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - GEN
AU - Lathers, Claire M.
AU - Schraeder, Paul L.
AU - Bungo, Michael W.
T1 - Reply
JO - Epilepsy & Behavior
JF - Epilepsy & Behavior
Y1 - 2008/07//
VL - 13
IS - 1
M3 - Letter
SP - 265
EP - 269
SN - 15255050
N1 - Accession Number: 32648609; Lathers, Claire M. 1; Email Address: lathers@attglobal.net Schraeder, Paul L. 2 Bungo, Michael W. 3; Affiliation: 1: Center for Veterinary Medicine U.S. Food and Drug Administration Rockville, MD 20855, USA 2: Department of Neurology Drexel University College of Medicine Philadelphia, PA 19102, USA 3: University of Texas Medical School 6431 Fannin Street, MSB 1.242 Houston, TX 77030, USA; Source Info: Jul2008, Vol. 13 Issue 1, p265; Number of Pages: 5p; Document Type: Letter
L3 - 10.1016/j.yebeh.2008.01.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bishop, Christine E.
AU - Weinberg, Dana Beth
AU - Leutz, Walter
AU - Dossa, Almas
AU - Pfefferle, Susan G.
AU - Zincavage, Rebekah M.
T1 - Nursing Assistants' job Commitment: Effect of Nursing Home Organizational Factors and Impact on Resident Well-Being.
JO - Gerontologist
JF - Gerontologist
Y1 - 2008///Jul2008 Special Issue 1
VL - 48
M3 - Article
SP - 36
EP - 45
SN - 00169013
AB - Purpose: The purpose of this study was to investigate (a) whether certified nursing assistants (CNAs) are more committed to nursing home lobs when they perceive their lobs as enhanced (greater autonomy, use of knowledge, teamwork), and (b) whether CNA lob commitment affects resident satisfaction. Design and Methods: A qualitative exploration of management philosophy and practice and of CNAs' views of their lobs in 1 8 Massachusetts nursing homes formed the basis for a survey administered to 255 CNAs in 15 homes. A quality-of-life questionnaire was administered to 105 residents. Logistic regression accounting for clustering estimated the effect of personal characteristics, satisfaction with tangible lob rewards, and aspects of lob design on CNAs' intent to stay in current lobs. A general linear model estimated the effect of job commitment on residents' satisfaction with their relationship to nursing staff. Results: After we accounted for satisfaction with wages, benefits, and advancement opportunities, good basic supervision was most important in affecting CNAs' intent to stay in their lobs. Job enhancements were not significantly related to intent to stay. Residents were more satisfied with their relationships to nursing staff and their quality of life on units where a higher proportion of CNAs were committed to their lobs. Implications: The finding that greater lob commitment of CNAs is associated with better quality of relationships and life for residents implies that better lobs lead to better care. Culture change transformation that increases CNA autonomy, knowledge input, and teamwork may not increase workers' commitment to lobs without improvements in basic supervision. [ABSTRACT FROM AUTHOR]
AB - Copyright of Gerontologist is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSES' aides
KW - NURSING care facilities
KW - RESIDENTS (Medicine)
KW - HEALTH facilities
KW - LOGISTIC regression analysis
KW - ALLIED health personnel
KW - Culture change
KW - Front/me caregivers
KW - High-performance management
KW - Turnover
KW - Work force
N1 - Accession Number: 34753028; Bishop, Christine E. 1; Email Address: bishop@brandeis.edu Weinberg, Dana Beth 2 Leutz, Walter 1 Dossa, Almas 3 Pfefferle, Susan G. 4 Zincavage, Rebekah M. 1; Affiliation: 1: Schneider Institutes for Health Policy, Heller School for Social Policy and Management, Brandeis University, Waltham, MA 2: Department of Sociology, Queens College—City University of New York, Flushing 3: Center for Health Quality, Outcomes, and Economic Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 4: Center for Mental Health Services Research, The George Warren Brown School of Social Work, Washington University in St. Louis, MO; Source Info: Jul2008 Special Issue 1, Vol. 48, p36; Subject Term: NURSES' aides; Subject Term: NURSING care facilities; Subject Term: RESIDENTS (Medicine); Subject Term: HEALTH facilities; Subject Term: LOGISTIC regression analysis; Subject Term: ALLIED health personnel; Author-Supplied Keyword: Culture change; Author-Supplied Keyword: Front/me caregivers; Author-Supplied Keyword: High-performance management; Author-Supplied Keyword: Turnover; Author-Supplied Keyword: Work force; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Neton, James W.
AU - Howard, John
AU - Elliott, Larry J.
T1 - RADIATION DOSE RECONSTRUCTION PROGRAM OF THE NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH: OVERVIEW.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 6
EP - 13
SN - 00179078
AB - The article presents an overview of the U.S. National Institute for Occupational Safety and Health's (NIOSH) Radiation Dose Reconstruction Program. The program was developed after epidemiologic research indicated associations between work-related exposures and illness at the facilities of the U.S. Department of Energy (DOE). The claims management process as well as the dose reconstruction process are discussed. One of the objectives in developing the dose reconstruction program is to ensure that the processing of claims would be effective, efficient and timely.
KW - Radiation exposure
KW - Radiation
KW - Industrial safety
KW - Claims
KW - United States
KW - dose assessment
KW - exposure, occupational
KW - monitoring, personal
KW - nuclear workers
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 32799043; Neton, James W. 1; Email Address: jfn2@cdc.gov; Howard, John 2; Elliott, Larry J.; Affiliations: 1: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998; 2: National Institute for Occupational Safety and Health, 395 E. Street, S,W., Suite 9200, Washington, DC 20201; Issue Info: Jul2008, Vol. 95 Issue 1, p6; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Thesaurus Term: Industrial safety; Subject Term: Claims; Subject: United States; Author-Supplied Keyword: dose assessment; Author-Supplied Keyword: exposure, occupational; Author-Supplied Keyword: monitoring, personal; Author-Supplied Keyword: nuclear workers ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kenoyer, Judson L.
AU - Scalsky, Edward D.
AU - Taulbee, Timothy D.
T1 - DEVELOPMENT OF SITE PROFILES FOR DOSE RECONSTRUCTION USED IN WORKER COMPENSATION CLAIMS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 47
EP - 54
SN - 00179078
AB - The article discusses the development of site profiles for dose reconstruction used in worker compensation claims under the Radiation Dose Reconstruction Program of the U.S. National Institute for Occupational Safety and Health (NIOSH). The NIOSH developed site profiles for all the major U.S. Department of Energy (DOE) sites and Atomic Weapons Employer sites. Site profiles provide a brief, general overview of the site. These documents also identify the facilities on site with a brief description of the processes and radionuclides used in these processes.
KW - Radiation exposure
KW - Radiation
KW - Claims
KW - Workers' compensation
KW - United States
KW - dose reconstruction
KW - environmental assessment
KW - exposure, occupational
KW - nuclear workers
KW - National Institute for Occupational Safety & Health
KW - United States. Dept. of Energy
N1 - Accession Number: 32799048; Kenoyer, Judson L. 1; Email Address: jkenoyer@moellerinc.com; Scalsky, Edward D. 1; Taulbee, Timothy D. 2; Affiliations: 1: Dade Moeller & Associate,, Inc., 2750 Prosperity Avenue, Suite 500, Fairfax,. VA 22031; 2: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratory, 4676 Columbia Parkway, Cincinnati, OH 45226; Issue Info: Jul2008, Vol. 95 Issue 1, p47; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Subject Term: Claims; Subject Term: Workers' compensation; Subject: United States; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: environmental assessment; Author-Supplied Keyword: exposure, occupational; Author-Supplied Keyword: nuclear workers ; Company/Entity: National Institute for Occupational Safety & Health ; Company/Entity: United States. Dept. of Energy; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brackett, Elizabeth M.
AU - Allen, David E.
AU - Siebert, Scott R.
AU - La Bone, Thomas R.
T1 - INTERNAL DOSE RECONSTRUCTION UNDER PART B OF THE ENERGY EMPLOYEES COMPENSATION ACT.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 69
EP - 80
SN - 00179078
AB - The article discusses the reconstruction of internal doses under Part B of the Energy Employees Occupational Illness Compensation Program Act differs which differs ways from that used in a typical operational setting. Under the legislation, no limits at or above which doses must be assessed; all doses, including unmonitored or potentially undetected doses, must be reconstructed. Also, the primary dose of concern is that delivered to the organ in which the cancer originated, and only the dose delivered to that organ prior to the time the cancer was diagnosed is relevant. To address these problems, the U.S. National Institute for Occupational Safety and Health (NIOSH) adopted a set of default values that are favorable to the claimant when there is more than one plausible choice.
KW - Radiation exposure
KW - Radiation
KW - Employee fringe benefits
KW - Employee assistance programs
KW - Cancer
KW - United States
KW - bioassay
KW - dose reconstruction
KW - dosimetry, internal
KW - occupational exposure
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 32799050; Brackett, Elizabeth M. 1; Email Address: ebrackett@oraucoc.org; Allen, David E. 2; Siebert, Scott R. 1; La Bone, Thomas R. 1; Affiliations: 1: MJW Corporation, 1900 Sweet Home Road, Amherst, NY 14228-3359; 2: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998; Issue Info: Jul2008, Vol. 95 Issue 1, p69; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Subject Term: Employee fringe benefits; Subject Term: Employee assistance programs; Subject Term: Cancer; Subject: United States; Author-Supplied Keyword: bioassay; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: dosimetry, internal; Author-Supplied Keyword: occupational exposure ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 12p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ulsh, Brant A.
AU - Rich, Bryce L.
AU - Chew, Melton H.
AU - Morris, Robert L.
AU - Sharfi, Mutty
AU - Rolfes, Mark R.
T1 - ESTABLISHING BOUNDING INTERNAL DOSE ESTIMATES FOR THORIUM ACTIVITIES AT ROCKY FLATS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 81
EP - 88
SN - 00179078
AB - The article highlights the evaluation of a Special Exposure Cohort petition filed on behalf of workers at the Rocky Flats Plant. As part of the evaluation, the U.S. National Institute for Occupational Safety and Health (NIOSH) was required to demonstrate that bounding values could be established for radiation doses due to the potential intake of all radionuclides present at the Rocky Flats. The main radioactive elements of interest at the facility were plutonium and uranium, but much smaller quantities of several other elements, including thorium. The results of NIOSH's investigation of the uses of thorium at Rocky Flats are presented.
KW - Radiation exposure
KW - Radiation
KW - Uranium
KW - Plutonium
KW - Thorium
KW - Radioactive substances
KW - United States
KW - 232Th
KW - dose assessment
KW - dose reconstruction
KW - thorium
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 32799051; Ulsh, Brant A. 1; Email Address: bau6@cdc.gov; Rich, Bryce L. 2; Chew, Melton H. 2; Morris, Robert L. 2; Sharfi, Mutty 3; Rolfes, Mark R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop C-46, Cincinnati, OH 45226; 2: M.H. Chew & Associates, Inc., 7275 National Drive, Suite C, Livermore, CA 94550-8868; 3: MJW Corporation, 1900 Sweet Home Road, Amherst, NY 14228-3359; Issue Info: Jul2008, Vol. 95 Issue 1, p81; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Thesaurus Term: Uranium; Thesaurus Term: Plutonium; Thesaurus Term: Thorium; Thesaurus Term: Radioactive substances; Subject: United States; Author-Supplied Keyword: 232Th; Author-Supplied Keyword: dose assessment; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: thorium ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Merwin, Steven E.
AU - Smith, Matthew H.
AU - Winslow, Robert C.
AU - McCartney, Keith A.
AU - Fix, Jack J.
AU - Taulbee, Timothy D.
AU - Macievic, Gregory L.
T1 - EXTERNAL DOSE RECONSTRUCTION UNDER PART B OF THE ENERGY EMPLOYEES COMPENSATION ACT.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 95
EP - 106
SN - 00179078
AB - The article discusses the assessment of external dose reconstruction under Part B of the Energy Employees Occupational Illness Compensation Program Act in the U.S. External doses include not only those that were recorded by personal dosimeters, but also those that were not recorded. Recorded doses may require corrections to account for measurement bias in the dosimeters' capabilities. Unrecorded doses that have been reconstructed include: those missed due to limits of detection associated with personal dosimeters; external ambient doses that may have been omitted from the monitoring results; and those incurred as a result of medical x-ray examinations required by employers.
KW - Radiation exposure
KW - Radiation
KW - Radiation dosimetry
KW - Nuclear counters
KW - Employee fringe benefits
KW - Dosimeters
KW - Employees
KW - United States
KW - dose reconstruction
KW - dose, external
KW - dosimetry, external
KW - nuclear workers
N1 - Accession Number: 32799053; Merwin, Steven E. 1; Email Address: semerwin@moellerinc.com; Smith, Matthew H. 1; Winslow, Robert C. 1; McCartney, Keith A. 2; Fix, Jack J. 1; Taulbee, Timothy D. 3; Macievic, Gregory L. 3; Affiliations: 1: Dade Moeller & Associates, 1835 Terminal Drive, Suite 200, Richland, WA 99352; 2: Dade Moeller & Associates, 4850 Smith Road, Cincinnati, OH 45212; 3: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, 4676 Columbia Parkway, Cincinnati, OH 45230; Issue Info: Jul2008, Vol. 95 Issue 1, p95; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Subject Term: Radiation dosimetry; Subject Term: Nuclear counters; Subject Term: Employee fringe benefits; Subject Term: Dosimeters; Subject Term: Employees; Subject: United States; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: dose, external; Author-Supplied Keyword: dosimetry, external; Author-Supplied Keyword: nuclear workers; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 12p; Illustrations: 12 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kocher, David C.
AU - Apostoaei, A. Iulian
AU - Henshaw, Russell W.
AU - Hoffman, F. Owen
AU - Schubauer-Berigan, Mary K.
AU - Stancescu, Daniel O.
AU - Thomas, Brian A.
AU - Trabalka, John R.
AU - Gilbert, Ethel S.
AU - Land, Charles E.
T1 - INTERACTIVE RADIOEPIDEMIOLOGICAL PROGRAM (IREP): A WEB-BASED TOOL FOR ESTIMATING PROBABILITY OF CAUSATION/ASSIGNED SHARE OF RADIOGENIC CANCERS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 119
EP - 147
SN - 00179078
AB - The article describes models and methods that are incorporated in the Interactive RadioEpidemiological Program (IREP) to estimate cancer risks and the probability that a given cancer in a worker was induced by given exposures to ionizing radiation. IREP, a Web-based, interactive computer code, was developed by a Working Group of the National Cancer Institute in the U.S. An important characteristic of IREP is that it accounts for uncertainties in estimating cancer risks due to exposure to ionizing radiation and in evaluating causation of a given cancer in an employee.
KW - Radiation exposure
KW - Radiation
KW - Industrial hygiene
KW - Ionizing radiation -- Measurement
KW - Cancer -- Risk factors
KW - United States
KW - cancer
KW - dose reconstruction
KW - radiation risk
KW - risk analysis
KW - National Cancer Institute (U.S.)
N1 - Accession Number: 32799055; Kocher, David C. 1; Email Address: dck@senes.com; Apostoaei, A. Iulian 1; Henshaw, Russell W. 2; Hoffman, F. Owen 1; Schubauer-Berigan, Mary K. 2; Stancescu, Daniel O. 3; Thomas, Brian A. 1; Trabalka, John R. 1; Gilbert, Ethel S. 4; Land, Charles E. 4; Affiliations: 1: SENES Oak Ridge, Inc., 102 Donner Drive, Oak Ridge, TN 37830; 2: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226; 3: SRA International, Inc., 2605 Meridian Parkway, Durham, NC 27713; 4: Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 28092-7335; Issue Info: Jul2008, Vol. 95 Issue 1, p119; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Thesaurus Term: Industrial hygiene; Subject Term: Ionizing radiation -- Measurement; Subject Term: Cancer -- Risk factors; Subject: United States; Author-Supplied Keyword: cancer; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: radiation risk; Author-Supplied Keyword: risk analysis ; Company/Entity: National Cancer Institute (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 29p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Merwin, Steven E.
AU - Stewart, Donald N.
AU - Smith, Matthew H.
AU - Potter, Kenneth D.
AU - Hinnefeld, Stuart L.
T1 - IMPLICATIONS OF CLAIMANT-FAVORABLE APPROACHES USED IN DOSE AND PROBABILITY OF CAUSATION CALCULATIONS UNDER EEOICPA.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 148
EP - 159
SN - 00179078
AB - The article discusses how the technical aspects of the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA) that favor the claimants are being implemented in the U.S. It states that there are many claimant, favorable factors inherent in both the reconstruction of radiation dose and the calculation of probability of causation under Part B of the EEOICPA in the U.S. These factors, according to the authors, result in an approximate 30% compensation rate for claims filed under EEOICPA, which is roughly an order of magnitude greater than the likely incidence of increased cancers as predicted by epidemiology studies and risk models.
KW - Radiation exposure
KW - Radiation
KW - Employee fringe benefits
KW - Ionizing radiation -- Dosage
KW - Ionizing radiation -- Measurement
KW - Claims
KW - Insurance claims
KW - United States
KW - cancer
KW - dose reconstruction
KW - dosimetry, external
KW - dosimetry, internal
N1 - Accession Number: 32799056; Merwin, Steven E. 1; Email Address: semerwin@moellerinc.com; Stewart, Donald N. 1; Smith, Matthew H. 1; Potter, Kenneth D. 1; Hinnefeld, Stuart L. 2; Affiliations: 1: Dade Moeller & Associates, 1835 Terminal Drive, Suite 200, Richland, WA 99352; 2: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, 4676 Columbia Parkway, Cincinnati, OH 45230; Issue Info: Jul2008, Vol. 95 Issue 1, p148; Thesaurus Term: Radiation exposure; Thesaurus Term: Radiation; Subject Term: Employee fringe benefits; Subject Term: Ionizing radiation -- Dosage; Subject Term: Ionizing radiation -- Measurement; Subject Term: Claims; Subject Term: Insurance claims; Subject: United States; Author-Supplied Keyword: cancer; Author-Supplied Keyword: dose reconstruction; Author-Supplied Keyword: dosimetry, external; Author-Supplied Keyword: dosimetry, internal; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 525190 Other Insurance Funds; Number of Pages: 12p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Neton, James W.
AU - Elliott, Larry J.
T1 - THE NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH RADIATION DOSE RECONSTRUCTION PROGRAM: COMMENTARY AND CONCLUSIONS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 160
EP - 163
SN - 00179078
AB - This article presents the authors' commentary and conclusions on the Radiation Dose Reconstruction Program of the U.S. National Institute for Occupational Safety and Health (NIOSH). The authors assert that the program is a complex scientific effort that draws from most of the technical aspects of the health physics profession. These activities, according to the authors, involve the assessment of internal and external doses for individuals who were exposed to occupationally related medical sources of ionizing radiation at Atomic Weapons Employer (AWE) and U.S. Department of Energy (DOE) facilities. The authors conclude that employees were potentially exposed to one or more of 15 defined categories of ionizing radiation.
KW - Radiation exposure
KW - Ionizing radiation
KW - Radiation
KW - Radioactivity
KW - Industrial safety
KW - United States
KW - National Institute for Occupational Safety & Health
KW - United States. Dept. of Energy
N1 - Accession Number: 32799057; Neton, James W.; Email Address: jneton@cdc.gov; Elliott, Larry J. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226 1998; Issue Info: Jul2008, Vol. 95 Issue 1, p160; Thesaurus Term: Radiation exposure; Thesaurus Term: Ionizing radiation; Thesaurus Term: Radiation; Thesaurus Term: Radioactivity; Thesaurus Term: Industrial safety; Subject: United States ; Company/Entity: National Institute for Occupational Safety & Health ; Company/Entity: United States. Dept. of Energy; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MALINAUSKAS, Richard A.
T1 - Decreased hemodialysis circuit pressures indicating postpump tubing kinks: A retrospective investigation of hemolysis in five patients.
JO - Hemodialysis International
JF - Hemodialysis International
Y1 - 2008/07//
VL - 12
IS - 3
M3 - Article
SP - 383
EP - 393
PB - Wiley-Blackwell
SN - 14927535
AB - The source of hemolysis during hemodialysis must be quickly identified to avoid life-threatening complications. At a single clinic, over a 10-day period in which 550 treatments were performed, 5 case-patients were retrospectively identified for experiencing acute hemolysis (4 deaths) from an unknown origin. The investigation focused on the postpump arterial tubing as the pressure was not monitored in this region, and the segment was shorter than required and could kink if overly stressed at bend points (i.e., tubing support clips, dialyzer inlet). To determine whether the circuit pressures indicated kinked tubing, a relative comparison between each case-patient's recorded arterial (prepump) and venous circuit pressures throughout their adverse event treatment and their immediately preceding treatment was conducted. Treatment pressure-time traces showed that sustained, significant decreases (>25 mmHg) in both of the circuit pressures occurred only on the hemolytic event dates. While direct observations of kinked tubing were not reported, the circuit pressure decreases could only be explained by severe postpump tube kinking causing a decrease in the blood flow rate. While postpump obstructions and hemolysis can occur without causing noticeable changes to the prepump arterial and venous blood line pressures (due to the highly occlusive setting of the roller blood pump), recognizing sudden and/or sustained decreases in the circuit pressures during treatment may help to prevent adverse patient events. This analysis reinforces the importance of regularly checking the blood tubing set for kinks and for monitoring the circuit pressures for atypical trends within and between treatments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Hemodialysis International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMODIALYSIS
KW - HEMOLYSIS & hemolysins
KW - DIALYSIS (Chemistry)
KW - THERAPEUTICS
KW - ANTIGEN-antibody reactions
KW - adverse event
KW - blood lines
KW - circuit pressures
KW - hemodialysis
KW - Hemolysis
KW - tubing kink
N1 - Accession Number: 34186887; MALINAUSKAS, Richard A. 1; Email Address: richard.malinauskas@fda.hhs.gov; Affiliation: 1: U.S. Food & Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, Maryland, U.S.A.; Source Info: Jul2008, Vol. 12 Issue 3, p383; Subject Term: HEMODIALYSIS; Subject Term: HEMOLYSIS & hemolysins; Subject Term: DIALYSIS (Chemistry); Subject Term: THERAPEUTICS; Subject Term: ANTIGEN-antibody reactions; Author-Supplied Keyword: adverse event; Author-Supplied Keyword: blood lines; Author-Supplied Keyword: circuit pressures; Author-Supplied Keyword: hemodialysis; Author-Supplied Keyword: Hemolysis; Author-Supplied Keyword: tubing kink; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; Number of Pages: 11p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1542-4758.2008.00285.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Meehye
AU - Wolt, Jeffrey D.
T1 - Cadmium Exposure in the South Korean Population: Implications of Input Assumptions for Deterministic Dietary Assessment.
JO - Human & Ecological Risk Assessment
JF - Human & Ecological Risk Assessment
Y1 - 2008/07//Jul/Aug2008
VL - 14
IS - 4
M3 - Article
SP - 835
EP - 850
SN - 10807039
AB - Dietary exposure to Cadmium (Cd) is of increasing interest globally because of the adverse health effects of Cd arising from multiple sources. The assumptions used when undertaking deterministic assessment of Cd in global or regional diets have implications when applied to specific national cases representing local variation in food composition and consumption patterns different from global or regional norms. We have conducted deterministic dietary Cd exposure assessments for the South Korean population using a variety of schemes for point estimation. Consumption data from the Korean Nutrition Survey (2001 to 2003) and monitoring data from the Korea Food and Drug Administration were used as the basis for the exposure estimates. The average daily per capita Cd exposure was 14 μ g for the South Korean population, representing about 27% of tolerable daily intake (TDI) and is similar to that reported in other countries. The hazard index (HI, the ratio of total Cd exposure to the TDI) typically ranged from 0.3 to 0.9 depending on assumptions used in deterministic estimates of dietary exposure. Even though the current exposure of the South Korean population at large is found to be safe on the basis of these estimates, consideration of high-end patterns of Cd level and consumption suggests the need for continued vigilance in dietary Cd monitoring. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human & Ecological Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM
KW - RESEARCH
KW - FOOD -- Composition
KW - CONSUMPTION (Economics)
KW - FOOD -- Analysis
KW - FOOD science
KW - NUTRITION
KW - HEALTH
KW - cadmium
KW - dietary exposure
KW - hazard index
KW - risk assessment
N1 - Accession Number: 33325244; Kim, Meehye 1 Wolt, Jeffrey D. 2; Email Address: jdwolt@iastate.edu; Affiliation: 1: Korea Food and Drug Administration, National Institute of Toxicology Research, Seoul, South Korea 2: Department of Agronomy, Iowa State University, Ames, IA, USA; Source Info: Jul/Aug2008, Vol. 14 Issue 4, p835; Subject Term: CADMIUM; Subject Term: RESEARCH; Subject Term: FOOD -- Composition; Subject Term: CONSUMPTION (Economics); Subject Term: FOOD -- Analysis; Subject Term: FOOD science; Subject Term: NUTRITION; Subject Term: HEALTH; Author-Supplied Keyword: cadmium; Author-Supplied Keyword: dietary exposure; Author-Supplied Keyword: hazard index; Author-Supplied Keyword: risk assessment; Number of Pages: 16p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10807030802235300
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cawley, James C.
AU - Homce, Gerald T.
T1 - Trends in Electrical Injury in the U.S., 1992—2002.
JO - IEEE Transactions on Industry Applications
JF - IEEE Transactions on Industry Applications
Y1 - 2008/07//Jul/Aug2008
VL - 44
IS - 4
M3 - Article
SP - 962
EP - 972
SN - 00939994
AB - This paper updates an earlier report by the authors that studied electrical injuries from 1992 to 1998. The previous information is expanded and supplemented with fatal and nonfatal injury rates and trends through 2002. Injury numbers and rates were used to compare and trend electrical injury experience for various groups and categories. This information allowed identification of at-risk groups that could most benefit from effective electrical safety interventions. The data presented in this paper are derived from the U.S. Labor Department's Bureau of Labor Statistics' Census of Fatal Occupational Injuries, Survey of Occupational Illnesses and Injuries, and Current Population Survey. Between 1992 and 2002, 3378 workers died from on-the-job electrical injuries. Electricity remained the sixth leading cause of injury-related occupational death. From 1999 to 2002, 4.7% of all occupational deaths were caused by electricity, down from 5.2% in the 1992-1998 time period. The cause of death was listed as electrocution in 99.1% of fatal cases. Contact with overhead power lines was involved in 42% of all on-the-job electrical deaths. The construction industry accounted for 47% of all electrical deaths between 1992 and 2002 but showed overall improvement from 1995 to 2002 by reducing its electrical fatality rate from 2.2 to 1.5 per 100 000 workers. In addition, 46 598 workers were nonfatally injured by electricity. Contact with electric current of machine, tool, appliance, or light fixture and contact with wiring, transformers, or other electrical components accounted for 36% and 34% of nonfatal electrical injuries, respectively. Contact with underground buried power lines was involved with 1% of fatal injuries and 2% of nonfatal injuries. The research of the National Institute for Occupational Safety and Health aimed at evaluating commercially available overhead power line proximity warning alarms is described. This paper is expected to be the initial step for eventual development of a performance standard for such systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Industry Applications is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACCIDENTS -- Research
KW - ACCIDENT prevention
KW - ELECTRICAL injuries
KW - ELECTRICAL burns
KW - ELECTRIC shock
KW - ELECTRICITY -- Safety measures
KW - ELECTROCUTION
KW - CAPITAL punishment
KW - UNITED States
KW - Electrical burn
KW - electrical injury
KW - electrical safety
KW - electrical shock
KW - electrocution
KW - fatality rate
KW - injury rate
N1 - Accession Number: 34264052; Cawley, James C. 1; Email Address: JCawley@cdc.gov Homce, Gerald T. 1; Email Address: GHomce@cdc.gov; Affiliation: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236 USA; Source Info: Jul/Aug2008, Vol. 44 Issue 4, p962; Subject Term: ACCIDENTS -- Research; Subject Term: ACCIDENT prevention; Subject Term: ELECTRICAL injuries; Subject Term: ELECTRICAL burns; Subject Term: ELECTRIC shock; Subject Term: ELECTRICITY -- Safety measures; Subject Term: ELECTROCUTION; Subject Term: CAPITAL punishment; Subject Term: UNITED States; Author-Supplied Keyword: Electrical burn; Author-Supplied Keyword: electrical injury; Author-Supplied Keyword: electrical safety; Author-Supplied Keyword: electrical shock; Author-Supplied Keyword: electrocution; Author-Supplied Keyword: fatality rate; Author-Supplied Keyword: injury rate; Number of Pages: 11p; Illustrations: 6 Charts, 12 Graphs; Document Type: Article
L3 - 10.1109/TIA.2008.926229
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34264052&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - Ultrasonic Scattering from Cancellous Bone: A Review.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2008/07//
VL - 55
IS - 7
M3 - Article
SP - 1432
EP - 1441
SN - 08853010
AB - This paper reviews theory, measurements, and computer simulations of scattering from cancellous bone reported by many laboratories. Three theoretical models (binary mixture, Faran cylinder, and weak scattering) for scattering from cancellous bone have demonstrated some consistency with measurements of backscatter. Backscatter is moderately correlated with bone mineral density in human calcaneus in vitro (r² = 0.66 - 0.68). Backscatter varies approximately as frequency cubed and trabecular thickness cubed in human calcaneus and femur in vitro. Backscatter from human calcaneus and bovine tibia exhibits substantial anisotropy. So far, backscatter has demonstrated only modest clinical utility. Computer simulation models have helped to elucidate mechanisms underlying scattering from cancellous bones. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEEL bone
KW - FEMUR
KW - BONES
KW - ANISOTROPY
KW - BONE density
N1 - Accession Number: 33216243; Wear, Keith A. 1; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD; Source Info: Jul2008, Vol. 55 Issue 7, p1432; Subject Term: HEEL bone; Subject Term: FEMUR; Subject Term: BONES; Subject Term: ANISOTROPY; Subject Term: BONE density; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1109/TUFFC .2008.8 18
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - A Method for Improved Standardization of in Vivo Calcaneal Time-Domain Speed-of-Sound Measurements.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2008/07//
VL - 55
IS - 7
M3 - Article
SP - 1473
EP - 1479
SN - 08853010
AB - Although calcaneal speed of sound (SOS) is an effective predictor of osteoporotic fracture risk, clinical SOS measurements exhibit a high degree of inter-system variability. Calcaneal SOS is usually computed from time-of-flight measurements of broadband ultrasound pulses that propagate through the foot. In order to minimize the effects of multipath interference, many investigators measure time-of-flight from markers near the leading edge of the pulse. The calcaneus is a highly attenuating, highly inhomogeneous bone that distorts propagating ultrasound pulses via frequency-dependent attenuation, reverberation, dispersion, multiple scattering, and refraction. This pulse distortion can produce errors in leading-edge transit-time marker-based SOS measurements. In this paper, an equation to predict dependence of time-domain SOS measurements on system parameters (center frequency and bandwidth), transit-time marker location, and bone properties (attenuation coefficient and thickness) is validated with through-transmission measurements in a bone-mimicking phantom and in 73 women in vivo, using a clinical bone sonometer. In order to test the utility of the formula for suppressing system dependence of SOS measurements, a wideband laboratory data acquisition system was used to make a second set of through-transmission measurements on the phantom. The compensation formula reduced system-dependent leading-edge transit-time marker-based SOS measurements in the phantom from 41 m/s to 5 m/s and reduced average transit-time marker-related SOS variability in 73 women from 40 m/s to 10 m/s. The compensation formula can be used to improve standardization in bone sonometry. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEEL bone
KW - BONES
KW - MUSCULOSKELETAL system
KW - PHYSIOLOGY
KW - ULTRASONIC imaging
N1 - Accession Number: 33216247; Wear, Keith A. 1; Email Address: keitthwear@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20852; Source Info: Jul2008, Vol. 55 Issue 7, p1473; Subject Term: HEEL bone; Subject Term: BONES; Subject Term: MUSCULOSKELETAL system; Subject Term: PHYSIOLOGY; Subject Term: ULTRASONIC imaging; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1109/TUFFC.2008.822
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33216247&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kato, Noritada
AU - Takahashi, Masaya
AU - Aratake, Yutaka
AU - Watanabe, Mayumi
AU - Sakata, Yumi
AU - Kojima, Reiko
AU - Kakinuma, Mitsuru
AU - Shibaoka, Michi
AU - Tanaka, Katsutoshi
T1 - Sleep-disordered Breathing and Hypertension in Japanese Steel Workers.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/07//
VL - 46
IS - 3
M3 - Article
SP - 233
EP - 238
SN - 00198366
AB - The article focuses on the occupational physicians' study administered to Japanese steel workers on the relationship between sleep-disordered breathing (SDB) and hypertension. According to an animal experiment, a significant increase of the daytime blood pressure was observed after the intermittent airway occlusion on the nocturnal sleep. This, however, was regarded by the Joint National Committee (JNC) as sleep apnea syndrome which is claimed to be an identifiable cause of hypertension.
KW - Animal experimentation
KW - Sleep apnea syndromes
KW - Hypertension
KW - Occupational physicians
KW - Iron & steel workers
KW - Japanese
KW - Japan
KW - Occupation
KW - Shift work
KW - Sleep duration
KW - Sleep-disordered breathing
N1 - Accession Number: 33261754; Kato, Noritada 1; Takahashi, Masaya 2; Aratake, Yutaka 1; Watanabe, Mayumi 1; Sakata, Yumi 1; Kojima, Reiko 1; Kakinuma, Mitsuru 1; Shibaoka, Michi 1; Tanaka, Katsutoshi 1; Affiliations: 1: Department of Occupational Mental Health, Graduate School of Medical Science Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan; 2: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2008, Vol. 46 Issue 3, p233; Thesaurus Term: Animal experimentation; Subject Term: Sleep apnea syndromes; Subject Term: Hypertension; Subject Term: Occupational physicians; Subject Term: Iron & steel workers; Subject Term: Japanese; Subject: Japan; Author-Supplied Keyword: Occupation; Author-Supplied Keyword: Shift work; Author-Supplied Keyword: Sleep duration; Author-Supplied Keyword: Sleep-disordered breathing; NAICS/Industry Codes: 238120 Structural Steel and Precast Concrete Contractors; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sommers, Connie L.
AU - Gurson, Jordan M.
AU - Surana, Rishi
AU - Barda-Saad, Mira
AU - Jan Lee
AU - Kishor, Aparna
AU - WenMei Li
AU - Gasser, Adam J.
AU - Barr, Valarie A.
AU - Miyaji, Michihiko
AU - Love, Paul E.
AU - Samelson, Lawrence E.
T1 - Bam32: a novel mediator of Erk activation in T cells.
JO - International Immunology
JF - International Immunology
Y1 - 2008/07//
VL - 20
IS - 7
M3 - Article
SP - 811
EP - 818
SN - 09538178
AB - Bam32 (B lymphocyte adapter molecule of 32 kDa) is an adapter protein expressed in some hematopoietic cells including B and T lymphocytes. It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including B cell receptor (BCR)-induced Erk activation, BCR-induced proliferation and T-independent antibody responses. In this study, we have examined the role of Bam32 in T cell activation using Bam32-deficient mice. By comparing CD4+ T cells from lymph nodes of wild-type and Bam32-deficient mice, we found that Bam32 was required for optimal TCR-induced Erk activation, cytokine production, proliferation and actin-mediated spreading of CD4+ T cells. These results indicate a novel pathway to Erk activation in T cells involving the adapter protein Bam32. [ABSTRACT FROM PUBLISHER]
AB - Copyright of International Immunology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - T cells
KW - HEMATOPOIETIC agents
KW - LYMPHOCYTES
KW - LYMPH nodes
KW - CELL receptors
KW - ANTIGEN presenting cells
KW - Erk
KW - IL-4
KW - proliferation
KW - T lymphocyte
KW - TCR
N1 - Accession Number: 44394820; Sommers, Connie L. 1 Gurson, Jordan M. 1 Surana, Rishi 1 Barda-Saad, Mira 1 Jan Lee 2 Kishor, Aparna 1 WenMei Li 1 Gasser, Adam J. 1 Barr, Valarie A. 1 Miyaji, Michihiko 1 Love, Paul E. 3 Samelson, Lawrence E. 1; Email Address: samelson@helix.nih.gov; Affiliation: 1: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 2: Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Jul2008, Vol. 20 Issue 7, p811; Subject Term: T cells; Subject Term: HEMATOPOIETIC agents; Subject Term: LYMPHOCYTES; Subject Term: LYMPH nodes; Subject Term: CELL receptors; Subject Term: ANTIGEN presenting cells; Author-Supplied Keyword: Erk; Author-Supplied Keyword: IL-4; Author-Supplied Keyword: proliferation; Author-Supplied Keyword: T lymphocyte; Author-Supplied Keyword: TCR; Number of Pages: 8p; Illustrations: 3 Diagrams, 2 Graphs; Document Type: Article
L3 - 10.1093/intimm/dxn039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44394820&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105651756
T1 - Asbestosis mortality surveillance in the United States, 1970-2004.
AU - Bang KM
AU - Mazurek JM
AU - Syamlal G
AU - Wood JM
Y1 - 2008/07//2008 Jul-Sep
N1 - Accession Number: 105651756. Language: English. Entry Date: 20080926. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9505217.
KW - Disease Surveillance
KW - Pneumoconiosis -- Mortality -- United States
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Demography
KW - Female
KW - Geographic Factors
KW - Male
KW - Middle Age
KW - Occupations and Professions
KW - Race Factors
KW - Sex Factors
KW - United States
KW - Human
SP - 161
EP - 169
JO - International Journal of Occupational & Environmental Health
JF - International Journal of Occupational & Environmental Health
JA - INT J OCCUP ENVIRON HEALTH
VL - 14
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - To describe the demographic, geographic, and occupational distribution of asbestosis mortality in the United States during 1970-2004, we identified a total of 25,413 asbestosis deaths. We calculated national, state, and county death rates, age-adjusted to the 2000 U.S. standard population. We also calculated industry- and occupation-specific proportionate mortality ratios (PMRs), adjusted for age, sex, and race, and corresponding confidence intervals (CIs) using available data. The overall U.S. age-adjusted asbestosis death rate was 4.1 per million population per year; the rate for males (10.4) was nearly 35-fold higher than that for females (0.3). It increased significantly from 0.6 to 6.9 per million population from 1970 to 2000 (p<0.001), and then declined to 6.3 in 2004 (p=0.014). High asbestosis death rates occurred predominantly, though not exclusively, in coastal areas. Industries with highest PMRs included ship and boat building and repairing (18.5; 95% CI 16.3-20.9) and miscellaneous nonmetallic mineral and stone products (15.9; 95% CI 13.0-19.5). Occupations with highest PMRs included insulation workers (109.2; 95% CI 93.8-127.2) and boilermakers (21.3; 95% CI 17.0-26.6).
SN - 1077-3525
AD - Division of Respiratory Disease Studies, RM H-G900.2, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, West Virginia 26505; kmb2@cdc.gov
U2 - PMID: 18686715.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fei Chen
AU - Beezhold, Kevin
AU - Castranova, Vince
T1 - Tumor Promoting or Tumor Suppressing of NF-κ B, a Matter of Cell Context Dependency.
JO - International Reviews of Immunology
JF - International Reviews of Immunology
Y1 - 2008/07//Jul/Aug2008
VL - 27
IS - 4
M3 - Article
SP - 183
EP - 204
PB - Taylor & Francis Ltd
SN - 08830185
AB - Nuclear factor-κ B (NF-κ B) and its activating signaling pathways are critical regulators for cell lineage development, growth, differentiation, apoptosis, and tumorigenic transformation. As one of the most important transcription factors, NF-κ B has been implicated in the transcriptional upregulation of a number of cytokines, adhesion molecules, growth factors, oncogenes, antiapoptotic proteins, some proapoptotic factors, and even certain viral genes. The role of NF-κ B on tumor promoting has been well-documented in the past two decades. However, during the past few years, a considerable number of studies suggested that NF-κ B and its activating signaling molecules may act as tumor suppressors under some circumstances. Thus, it is highly possible that tumor promoting or tumor suppressing of NF-κ B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Reviews of Immunology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLATION
KW - ALKYLATION
KW - TRANSCRIPTION factors
KW - CELLS
KW - PROTEINS
KW - epigenetics
KW - histone methylation
KW - JNK
KW - NF-κB
KW - NF-κB
KW - ROS
KW - tumor suppressing
N1 - Accession Number: 32771401; Fei Chen 1,2; Email Address: LFD3@cdc.gov Beezhold, Kevin 1,2 Castranova, Vince 1,3; Affiliation: 1: Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Graduate Program in Cancer Cell Biology, West Virginia University, Morgantown, West Virginia, USA 3: Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA; Source Info: Jul/Aug2008, Vol. 27 Issue 4, p183; Subject Term: METHYLATION; Subject Term: ALKYLATION; Subject Term: TRANSCRIPTION factors; Subject Term: CELLS; Subject Term: PROTEINS; Author-Supplied Keyword: epigenetics; Author-Supplied Keyword: histone methylation; Author-Supplied Keyword: JNK; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: ROS; Author-Supplied Keyword: tumor suppressing; Number of Pages: 22p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram; Document Type: Article
L3 - 10.1080/08830180802130327
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32771401&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Isaacs, S. G.
AU - Powers, L. A.
AU - Lineberry, G. T.
AU - Scharf, T.
T1 - Enhancing Cattle Handling Safety with the Work Crew Performance Model.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2008/07//
VL - 14
IS - 3
M3 - Article
SP - 261
EP - 271
SN - 10747583
AB - The article determines critical action factors (CAFs) for safe handling of cattle in Kentucky by appplying the principles of the Work Crew Performance Model. One focus group of farmers assisted pinpoint a set of 32 CAFS in four categories, namely, animal behavior, facilities and equipment, environmental conditions, and handling strategies. Another focus group of farmers utilized a Q-sort nominal group process to rate each of the factors based on the cost results of failures to do the activity. The results of the process was the creation of a cattle safety handling checklist that has been utilized successfully in Master Cattleman educational workshops performed for around 1,500 farmers in Kentucky.
KW - Industrial safety
KW - Cattle
KW - Agriculture
KW - Farmers
KW - Animal behavior
KW - Cattle industry
KW - Performance
KW - Industrial equipment
KW - Kentucky
KW - Cattle handling
KW - Cattle safety
KW - Q-Sort
KW - Work Crew Performance Model.
N1 - Accession Number: 34064772; Isaacs, S. G. 1; Email Address: sisaacs@uky.edu.; Powers, L. A. 2; Lineberry, G. T. 3; Scharf, T. 4; Affiliations: 1: Professor, Department of Agricultural Economics, University of Kentucky, Lexington, Kentucky; 2: Extension Specialist, University of Kentucky, Lexington, Kentucky; 3: Professor, Department of Mining Engineering, University of Kentucky, Lexington, Kentucky; 4: Research Psychologist, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Corresponding author: Steven G. lsaacs, 303 CE. Barnhart Bldg., Lexington, KY 40546-0276; Issue Info: Jul2008, Vol. 14 Issue 3, p261; Thesaurus Term: Industrial safety; Thesaurus Term: Cattle; Thesaurus Term: Agriculture; Thesaurus Term: Farmers; Thesaurus Term: Animal behavior; Subject Term: Cattle industry; Subject Term: Performance; Subject Term: Industrial equipment; Subject: Kentucky; Author-Supplied Keyword: Cattle handling; Author-Supplied Keyword: Cattle safety; Author-Supplied Keyword: Q-Sort; Author-Supplied Keyword: Work Crew Performance Model.; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 311614 Rendering and meat processing from carcasses; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417230 Industrial machinery, equipment and supplies merchant wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Espandiari, Parvaneh
AU - Zhang, Jun
AU - Schnackenberg, Laura K.
AU - Miller, Terry J.
AU - Knapton, Alan
AU - Herman, Eugene H.
AU - Beger, Richard D.
AU - Hanig, Joseph P.
T1 - Age-related differences in susceptibility to toxic effects of valproic acid in rats.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2008/07//
VL - 28
IS - 5
M3 - Article
SP - 628
EP - 637
SN - 0260437X
AB - The article presents a study which examines the effect of drugs in different age variations. It states that age is considered an important factor because of the non-linear maturation, which is related to drug absorption, distribution, metabolism and excretion (ADME). It mentions that drug dosage prescription are oftenly based on adult dosage. The effect of such practice can cause vital target organs vulnerabilities. The study makes use of a Sprague-Dawley (SD) rats as model and is exposed to a pediatric hepatotoxic agent called valporic acid (VPA). The rats mostly had 15 days age gap with different doses. The data shows results on platelet counts, rate of growth and the urine creatine concentration.
KW - Pharmacology
KW - Bioactive compounds
KW - TOXICOLOGY
KW - Drug metabolism -- Evaluation
KW - Pediatric oral medicine
KW - Drugs
KW - Drugs -- Absorption & adsorption
KW - Drugs -- Analysis
KW - Pharmaceutical chemistry
KW - Drugs -- Effectiveness
KW - age-related toxicity
KW - biomarkers
KW - stages of development
KW - valproic acid
N1 - Accession Number: 33435160; Espandiari, Parvaneh 1; Email Address: parvaneh.espandiari@fda.hhs.gov; Zhang, Jun 1; Schnackenberg, Laura K. 2; Miller, Terry J. 1; Knapton, Alan 1; Herman, Eugene H. 1; Beger, Richard D. 2; Hanig, Joseph P. 1; Affiliations: 1: FDA, Center for Drug Evaluation and Research, Silver Spring, MD, USA 20993; 2: FDA, National Center for Toxicological Research, Jefferson, AR 72079, USA; Issue Info: Jul2008, Vol. 28 Issue 5, p628; Thesaurus Term: Pharmacology; Thesaurus Term: Bioactive compounds; Thesaurus Term: TOXICOLOGY; Subject Term: Drug metabolism -- Evaluation; Subject Term: Pediatric oral medicine; Subject Term: Drugs; Subject Term: Drugs -- Absorption & adsorption; Subject Term: Drugs -- Analysis; Subject Term: Pharmaceutical chemistry; Subject Term: Drugs -- Effectiveness; Author-Supplied Keyword: age-related toxicity; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: stages of development; Author-Supplied Keyword: valproic acid; Number of Pages: 10p; Illustrations: 4 Charts, 8 Graphs; Document Type: Article
L3 - 10.1002/jat.1314
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sahu, Saura C.
AU - Wiesenfeld, Paddy L.
AU - Kim, Chung S.
AU - Ross, Ivan A.
AU - Sapienza, Philip P.
AU - Newell, Richard
AU - O'Donnell, Michael W.
AU - Flynn, Thomas J.
T1 - Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2008/07//
VL - 28
IS - 5
M3 - Article
SP - 703
EP - 709
SN - 0260437X
AB - The article presents a study which examines the hepatotoxic potential of steroid hormone called Androstenedione. The steroid hormone is known to enhance the performance of athletes. It stateas that Androstenedione is culturally treated with results for cytotosicity. It mentions that cytotoxicity is referred to the DNA content, cell viabilty, liver enzymes, oxidative stress and adinosine triphosphate cellular content. Comparisons were made on the results in female Sprague-Dawley rats. The study mentions the clone-9 cell model as not an effective model for hepatotoxicity androstenedione.
KW - Steroids
KW - Hormones
KW - Nucleic acids
KW - Androstenedione
KW - Physical fitness
KW - Hepatotoxicology
KW - Deoxyribose
KW - Genes
KW - Performance-enhancing drugs
KW - Androgens
KW - androstenedione
KW - clone-9 cells
KW - hepatotoxicity
KW - liver
KW - rat
N1 - Accession Number: 33435169; Sahu, Saura C. 1; Email Address: saura.sahu@fda.hhs.gov; Wiesenfeld, Paddy L. 1; Kim, Chung S. 1; Ross, Ivan A. 1; Sapienza, Philip P. 1; Newell, Richard 2; O'Donnell, Michael W. 2; Flynn, Thomas J. 1; Affiliations: 1: Division of Toxicology, Office of Applied Research and Safety Assessment, U. S. Food and Drug Administration, Laurel, MD 20708, USA; 2: Division of Mathematics, Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Jul2008, Vol. 28 Issue 5, p703; Thesaurus Term: Steroids; Thesaurus Term: Hormones; Thesaurus Term: Nucleic acids; Subject Term: Androstenedione; Subject Term: Physical fitness; Subject Term: Hepatotoxicology; Subject Term: Deoxyribose; Subject Term: Genes; Subject Term: Performance-enhancing drugs; Subject Term: Androgens; Author-Supplied Keyword: androstenedione; Author-Supplied Keyword: clone-9 cells; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: liver; Author-Supplied Keyword: rat; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1002/jat.1325
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ludu, Jagjit S.
AU - de Bruin, Olle M.
AU - Duplantis, Barry N.
AU - Schmerk, Crystal L.
AU - Chou, Alicia Y.
AU - Elkins, Karen L.
AU - Nano, Francis E.
T1 - The Francisella Pathogenicity Island Protein PdpD is Required for Full Virulence and Associates with Homolques of the Type Vi Secretion System.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008/07//
VL - 190
IS - 13
M3 - Article
SP - 4584
EP - 4595
SN - 00219193
AB - Francisella tularensis is a highly infectious, facultative intracellular bacterial pathogen that is the causative agent of tularemia. Nearly a century ago, researchers observed that tularemia was often fatal in North America but almost never fatal in Europe and Asia. The chromosomes of F. tularensis strains carry two identical copies of the Francisella pathogenicity island (FPI), and the FPIs of North America-specific biotypes contain two genes, anmK and pdpD, that are not found in biotypes that are distributed over the entire Northern Hemisphere. In this work, we studied the contribution of anmK and pdpD to virulence by using F. novicida, which is very closely related to F. tularensis but which carries only one copy of the FPI. We showed that anmK and pdpD are necessary for full virulence but not for intracellular growth. This is in sharp contrast to most other FPI genes that have been studied to date, which are required for intracellular growth. We also showed that PdpD is localized to the outer membrane. Further, overexpression of PdpD affects the cellular distribution of FPI-encoded proteins IglA, IglB, and IglC. Finally, deletions of FPI genes encoding proteins that are homologues of known components of type VI secretion systems abolished the altered distribution of IglC and the outer membrane localization of PdpD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FRANCISELLA tularensis
KW - FRANCISELLA
KW - GENES
KW - HEREDITY
KW - MOLECULAR genetics
KW - TULAREMIA
KW - GRAM-negative bacterial diseases
KW - TICK-borne diseases
KW - CELL nuclei
N1 - Accession Number: 33114618; Ludu, Jagjit S. 1 de Bruin, Olle M. 1 Duplantis, Barry N. 1 Schmerk, Crystal L. 1 Chou, Alicia Y. 2 Elkins, Karen L. 2 Nano, Francis E. 1; Email Address: fnano@uvic.ca; Affiliation: 1: Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; Source Info: Jul2008, Vol. 190 Issue 13, p4584; Subject Term: FRANCISELLA tularensis; Subject Term: FRANCISELLA; Subject Term: GENES; Subject Term: HEREDITY; Subject Term: MOLECULAR genetics; Subject Term: TULAREMIA; Subject Term: GRAM-negative bacterial diseases; Subject Term: TICK-borne diseases; Subject Term: CELL nuclei; Number of Pages: 10p; Document Type: Article
L3 - 10.1128/JB.00198-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Goldcamp, Michael J.
AU - Underwood, Melinda N.
AU - Cloud, Joshua L.
AU - Harshman, Sean
AU - Ashley, Kevin
T1 - An Environmentally Friendly, Cost-Effective Determination of Lead in Environmental Samples Using Anodic Stripping Voltammetry.
JO - Journal of Chemical Education
JF - Journal of Chemical Education
Y1 - 2008/07//
VL - 85
IS - 7
M3 - Article
SP - 976
EP - 979
SN - 00219584
AB - The article describes the use of new developments in anodic stripping voltammetry (ASV) in an experiment that analyzes environmental samples for Pb content. In this activity, students extract a sample such as riverbed sediment with dilute acid, facilitated by sonication and analyze it for Pb content using ASV. It also replaces traditional working electrodes with inexpensive, disposable graphite pencil lead electrodes. Its primary goal is to teach the analytical electrochemical method of ASV for trace metal analysis.
KW - VOLTAMMETRY
KW - LEAD
KW - RESEARCH
KW - ELECTRIC resistors
KW - ELECTRODES
KW - ELECTROCHEMICAL analysis
KW - ELECTRIC resistance
KW - QUANTITATIVE chemical analysis
KW - PHYSICAL & theoretical chemistry
KW - ENVIRONMENTAL chemistry
N1 - Accession Number: 32673425; Goldcamp, Michael J. 1; Email Address: michael_goIdcamp@wilmington.edu Underwood, Melinda N. 1 Cloud, Joshua L. 1 Harshman, Sean 1 Ashley, Kevin 2; Affiliation: 1: Department of Chemistry, Wilmington College, Wilmington, OH 45177 2: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH 45226; Source Info: Jul2008, Vol. 85 Issue 7, p976; Subject Term: VOLTAMMETRY; Subject Term: LEAD; Subject Term: RESEARCH; Subject Term: ELECTRIC resistors; Subject Term: ELECTRODES; Subject Term: ELECTROCHEMICAL analysis; Subject Term: ELECTRIC resistance; Subject Term: QUANTITATIVE chemical analysis; Subject Term: PHYSICAL & theoretical chemistry; Subject Term: ENVIRONMENTAL chemistry; NAICS/Industry Codes: 334416 Capacitor, Resistor, Coil, Transformer, and Other Inductor Manufacturing; NAICS/Industry Codes: 417320 Electronic components, navigational and communications equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423690 Other Electronic Parts and Equipment Merchant Wholesalers; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pylypchuk, Yuriy
AU - Selden, Thomas M.
T1 - A discrete choice decomposition analysis of racial and ethnic differences in children's health insurance coverage
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2008/07//
VL - 27
IS - 4
M3 - Article
SP - 1109
EP - 1128
SN - 01676296
AB - This paper presents a multivariate decomposition analysis of racial and ethnic differences in children''s health insurance using the 2004–2005 Medical Expenditure Panel Survey. We present two methodological contributions. First, we adapt a recently-developed matching decomposition method for use with sample-weighted data. Second, we develop a fully nonparametric approach that implements decomposition through weight adjustments. Accounting for the black–white wealth gap: a nonparametric approach. Journal of the American Statistical Association 97, 663–673]. Differences in observed characteristics explain large percentages of racial and ethnic coverage differences. Important contributors include poverty levels, parent education, family structure (for black children), and immigration-related factors (for Hispanic children). We also examine racial and ethnic differences in parent offers of employer-sponsored insurance and in children''s coverage conditional on having a parent offer. Comparison of our linear, nonlinear, and nonparametric results suggests researchers may face a trade-off between robustness and precision when selecting among decomposition methodologies for discrete outcomes. [Copyright &y& Elsevier]
AB - Copyright of Journal of Health Economics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - HEALTH insurance -- Social aspects
KW - DEMOGRAPHIC characteristics
KW - EMPLOYER-sponsored health insurance
KW - MEDICAL care costs
KW - MEDICAL economics
KW - C25
KW - Children
KW - Decomposition
KW - Health insurance
KW - I11
KW - Minorities
N1 - Accession Number: 32554336; Pylypchuk, Yuriy 1 Selden, Thomas M. 2; Email Address: tselden@ahrq.gov; Affiliation: 1: Social and Scientific Systems, 8757 Georgia Avenue, 12th Floor, Silver Spring, MD 20910, United States 2: Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, United States; Source Info: Jul2008, Vol. 27 Issue 4, p1109; Subject Term: CHILDREN -- Health; Subject Term: HEALTH insurance -- Social aspects; Subject Term: DEMOGRAPHIC characteristics; Subject Term: EMPLOYER-sponsored health insurance; Subject Term: MEDICAL care costs; Subject Term: MEDICAL economics; Author-Supplied Keyword: C25; Author-Supplied Keyword: Children; Author-Supplied Keyword: Decomposition; Author-Supplied Keyword: Health insurance; Author-Supplied Keyword: I11; Author-Supplied Keyword: Minorities; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 20p; Document Type: Article
L3 - 10.1016/j.jhealeco.2007.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105688769
T1 - Web-based reporting of the results of the 2006 Four Country Prevalence Survey of Healthcare Associated Infections.
AU - Harris S
AU - Morgan M
AU - Davies E
Y1 - 2008/07//
N1 - Accession Number: 105688769. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: English Department of Health and Welsh Assembly Government. NLM UID: 8007166.
KW - Cross Infection
KW - Prevalence
KW - Reports
KW - Surveys
KW - World Wide Web
KW - Consumer Satisfaction
KW - Databases
KW - England
KW - Feedback
KW - Funding Source
KW - Internet
KW - Ireland
KW - Northern Ireland
KW - Wales
KW - Human
SP - 258
EP - 264
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
JA - J HOSP INFECT
VL - 69
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - A web-base reporting system was developed in order to feed back the results of the 2006 prevalence survey of healthcare-associated infections in a timely manner to all participating hospitals in England, Wales and Northern Ireland. The database accommodated approximately 75 000 records from over 250 hospitals. The reporting system was hosted on the National Health Service intranet, accessible via secure login. Users were able to access their individual Trust data via a series of predefined reports and an export facility was included to facilitate additional analysis. The reporting system was made available to participating hospitals within 12 months of completion of the survey. From the results of a user satisfaction survey, end-users responded positively to receiving feedback in this format. It serves as a useful model for the feedback of results for future prevalence surveys.Copyright © 2008 by Elsevier Inc.
SN - 0195-6701
AD - Welsh Healthcare Associated Infection Programme (WHAIP), National Public Health Service, Cardiff, UK.
U2 - PMID: 18511152.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105688769&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anderson, Stacey E.
AU - Munson, Albert E.
AU - Tomblyn, Seth
AU - Meade, B. Jean
AU - Diotte, Nicole M.
T1 - The Humoral Immune Response of Mice Exposed to Simulated Road Paving-Like Asphalt Fumes.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2008/07//Jul-Sep2008
VL - 5
IS - 3
M3 - Article
SP - 307
EP - 313
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Asphalt is a complex mixture of organic molecules, including polycyclic aromatic hydrocarbons (PAH), which have been reported to cause serious adverse health effects in humans. Workers in manufacturing and construction trades exposed to asphalt are potentially at risk for being exposed to asphalt fumes and PAHs. Epidemiological investigations have collected mounting evidence that chemicals found in asphalt fumes present carcinogenic and possibly immunotoxic hazards. Studies evaluating the immunotoxic effects of asphalt fume are limited due to the large number of variables associated with asphalt fume exposures. This work investigates the immuno-toxic effects of road paving-like asphalt fume by analyzing the in vivo IgM response to a T-dependent antigen after exposure to whole, vapor, and particulate phase road paving-like asphalt fumes and asphalt fume condensate. Systemic exposures via intraperitoneal injection of asphalt fume condensate (at 0.625 mg/kg) and the particulate phase (at 5 mg/kg) resulted in significant reductions in the specific spleen IgM response to SRBC. Pharyngeal aspiration of the asphalt fume condensate (at 5 mg/kg) also resulted in significant suppression of the IgM response to SRBC. A significant reduction in the specific spleen IgM activity was observed after inhalation exposure to whole asphalt fumes (35 mg/m3) and the vapor components (11 mg/m3). Dermal exposures to the asphalt fume condensate resulted in significant reductions in the total (at 50 mg/kg) and specific (at 250 mg/kg) spleen IgM response to SRBC. These results demonstrate that exposure to road paving-like asphalt fumes is immunosuppressive through systemic, respiratory, and dermal routes of exposure in a murine model and raise concerns regarding the potential for adverse immunological effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asphalt pavements
KW - Asphalt
KW - Air pollution
KW - Hydrocarbons -- Environmental aspects
KW - Carcinogens
KW - Immunotoxicology
KW - Polycyclic aromatic hydrocarbons -- Physiological effect
KW - asphalt fumes
KW - immunotoxicity
KW - Paving asphalt
KW - PFC assay
KW - SRBC
N1 - Accession Number: 34571282; Anderson, Stacey E. 1; Munson, Albert E. 1; Tomblyn, Seth 1; Meade, B. Jean 1; Diotte, Nicole M. 2; Affiliations: 1: National Institute of Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Wayne State University, Detroit, Michigan, USA; Issue Info: Jul-Sep2008, Vol. 5 Issue 3, p307; Thesaurus Term: Asphalt pavements; Thesaurus Term: Asphalt; Thesaurus Term: Air pollution; Thesaurus Term: Hydrocarbons -- Environmental aspects; Thesaurus Term: Carcinogens; Subject Term: Immunotoxicology; Subject Term: Polycyclic aromatic hydrocarbons -- Physiological effect; Author-Supplied Keyword: asphalt fumes; Author-Supplied Keyword: immunotoxicity; Author-Supplied Keyword: Paving asphalt; Author-Supplied Keyword: PFC assay; Author-Supplied Keyword: SRBC; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 324122 Asphalt Shingle and Coating Materials Manufacturing; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; NAICS/Industry Codes: 324121 Asphalt Paving Mixture and Block Manufacturing; NAICS/Industry Codes: 238990 All Other Specialty Trade Contractors; Number of Pages: 7p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1080/15376510802312407
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105784114
T1 - Improving quality and reducing disparities: the role of nurses.
AU - Ho K
AU - Brady J
AU - Clancy CM
Y1 - 2008/07//Jul-Sep2008
N1 - Accession Number: 105784114. Language: English. Entry Date: 20080808. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9200672.
KW - Health Services Accessibility
KW - Nursing Role
KW - Quality of Health Care
KW - Communication
KW - Cultural Diversity
KW - Nursing Manpower
KW - Professional-Patient Relations
KW - Quality Improvement
SP - 185
EP - 188
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 23
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Maryland 20850.
U2 - PMID: 18562857.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105784114&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Boeniger, Mark
AU - Neumeister, Charles
AU - Booth-Jones, Angela
T1 - Sampling and Analytical Method Development and Hand Wipe Measurements of Dermal Exposures to Polycyclic Aromatic Hydrocarbons.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/07//
VL - 5
IS - 7
M3 - Article
SP - 417
EP - 425
PB - Taylor & Francis Ltd
SN - 15459624
AB - This article describes the laboratory assessment of a hand and surface wipe sampling method for polycyclic aromatic hydrocarbons (PAHs). The analytical method employed extraction of the wipe samples into dimethyl sulfoxide (DMSO) and high-performance liquid chromatography (HPLC) flourometric detection of pyrene, a predominant PAH in used gasoline engine oils (UGEO). Recovery of pyrene was evaluated for two different sampling media by first contaminating the hands of a small number of volunteers with UGEO, followed by applying a small amount of corn oil to the palms, and by wiping the skin with a Whatman cellulostic filter paper or a polyester fabric wipe (i.e., Alpha wipes). In summary, using either Whatman or Alpha wipes, the mean recovery of pyrene from the UGEO that was applied to the hands and contained within three consecutive wipes was 69% and 54%, respectively. However, the relative recovery of the first to second wipe was on average 47% and 75% for the two media, respectively. These results indicate that the Alpha wipes were more efficient at recovering pyrene in the first wipe but less efficient overall when all three consecutive samples were included. Even though this sampling was performed in a controlled laboratory environment, the minimum and maximum amount of pyrene recovered in the individual composite samples using either method spanned a range of twofold. Overall, intra-and interpersonal variability, as measured by coefficient of variation, were 22% and 19%, respectively, and were not statistically different by type of media used. This method was used in a pilot field survey to sample the hands of 18 automotive repair technicians and 18 office workers. Detectable amounts of pyrene (>0.2 μg/sample) were found on the hands of 61% and 0% of these two groups, respectively, with the highest measured quantity equal to 1.06 μg. Samples from the upper surfaces of automobile motors were generally low to nondetectable (<0.027 μg/sample), while the median value of 0.047 μg/50 cm2(CV = 160%) and up to 0.640 μg were found on the drip pans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Polycyclic aromatic compounds
KW - Dimethyl sulfoxide
KW - Chromatographic analysis
KW - Environmental sampling
KW - High performance liquid chromatography
KW - Pyrene (Chemical)
KW - Sampling (Process)
KW - analytical
KW - method
KW - PAH
KW - sampling
KW - skin
KW - wipe
N1 - Accession Number: 35167712; Boeniger, Mark 1; Neumeister, Charles 1; Booth-Jones, Angela 2; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Good Samaritan Hospital, Dayton, Ohio; Issue Info: Jul2008, Vol. 5 Issue 7, p417; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Polycyclic aromatic compounds; Thesaurus Term: Dimethyl sulfoxide; Thesaurus Term: Chromatographic analysis; Thesaurus Term: Environmental sampling; Subject Term: High performance liquid chromatography; Subject Term: Pyrene (Chemical); Subject Term: Sampling (Process); Author-Supplied Keyword: analytical; Author-Supplied Keyword: method; Author-Supplied Keyword: PAH; Author-Supplied Keyword: sampling; Author-Supplied Keyword: skin; Author-Supplied Keyword: wipe; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/15459620802111319
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McKernan, John L.
AU - Toraason, Mark A.
AU - Fernback, Joseph E.
T1 - Presence of Airborne Fibers in Tungsten Refining and Manufacturing Processes: Preliminary Characterization.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/07//
VL - 5
IS - 7
M3 - Article
SP - 463
EP - 474
PB - Taylor & Francis Ltd
SN - 15459624
AB - In tungsten refining and manufacturing processes, a series of tungsten oxides (WOX) are typically formed as intermediates in the production of tungsten powder. Studies in the Swedish tungsten refining and manufacturing industry have shown that intermediate tungsten refining processes can create WOX fibers. The purpose of the present study was to identify and provide a preliminary characterization of airborne tungsten-containing fiber dimensions, elemental composition, and concentrations in the U.S. tungsten refining and manufacturing industry. To provide the preliminary characterization, 10 static air samples were collected during the course of normal employee work activities and analyzed using standard fiber sampling and counting methods. Results from transmission electron microscopy analyses conducted indicate that airborne fibers with length > 0.5 μ m, diameter > 0.01 μ m, and aspect ratio ≥ 3:1, with a geometric mean (GM) length of ∼ 2.0 μ m and GM diameter of ∼ 0.25 μ m, were present on 9 of the 10 air samples collected. Energy dispersive X-ray spectrometry results indicate that airborne fibers prior to the carburization process consisted primarily of tungsten and oxygen, with other elements being detected in trace quantities. Results from an air sample collected at the carburization process indicated the presence of fibers composed primarily of tungsten with oxygen and carbon, and traces of other elements. Based on National Institute for Occupational Safety and Health standard fiber counting rules, airborne fiber concentrations ranged from below the limit of detection to 0.14 f/cm3. The calcining process was associated with the highest airborne fiber concentrations. More than 99% (574/578) of the airborne fibers identified had an aerodynamic diameter ≤10 μ m, indicating that they were capable of reaching the thoracic regions. Until more is known about the durability and potential health effects associated with airborne tungsten-containing fibers, it would be prudent to take steps to limit or eliminate occupational exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Air pollution
KW - Threshold limit values (Industrial toxicology)
KW - Industrial toxicology
KW - Metal fibers
KW - Tungsten fibers
KW - Tungsten
KW - Tungsten industry
KW - Electron microscopy
KW - Tungsten oxides
KW - electron microscopy
KW - hard-metal manufacturing
KW - occupational exposure
KW - thoracic
KW - tungsten blue oxide
KW - tungsten oxide bronze
N1 - Accession Number: 35167709; McKernan, John L. 1; Toraason, Mark A. 2; Fernback, Joseph E. 2; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jul2008, Vol. 5 Issue 7, p463; Thesaurus Term: Air pollution; Thesaurus Term: Threshold limit values (Industrial toxicology); Thesaurus Term: Industrial toxicology; Subject Term: Metal fibers; Subject Term: Tungsten fibers; Subject Term: Tungsten; Subject Term: Tungsten industry; Subject Term: Electron microscopy; Subject Term: Tungsten oxides; Author-Supplied Keyword: electron microscopy; Author-Supplied Keyword: hard-metal manufacturing; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: thoracic; Author-Supplied Keyword: tungsten blue oxide; Author-Supplied Keyword: tungsten oxide bronze; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 12p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620802143742
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105695163
T1 - Sampling and analytical method development and hand wipe measurements of dermal exposures to polycyclic aromatic hydrocarbons.
AU - Boeniger M
AU - Neumeister C
AU - Booth-Jones A
Y1 - 2008/07//
N1 - Accession Number: 105695163. Language: English. Entry Date: 20081121. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Note: For CE see Suppl pages D77-9. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Environmental Monitoring
KW - Hydrocarbons, Aromatic -- Analysis
KW - Occupational Exposure -- Analysis
KW - Skin Physiology
KW - Chromatography, Liquid
KW - Education, Continuing (Credit)
KW - Hand
KW - Motor Vehicles
KW - Petroleum
KW - Pilot Studies
KW - Risk Assessment
KW - Human
SP - 417
EP - 425
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This article describes the laboratory assessment of a hand and surface wipe sampling method for polycyclic aromatic hydrocarbons (PAHs). The analytical method employed extraction of the wipe samples into dimethyl sulfoxide (DMSO) and high-performance liquid chromatography (HPLC) flourometric detection of pyrene, a predominant PAH in used gasoline engine oils (UGEO). Recovery of pyrene was evaluated for two different sampling media by first contaminating the hands of a small number of volunteers with UGEO, followed by applying a small amount of corn oil to the palms, and by wiping the skin with a Whatman cellulostic filter paper or a polyester fabric wipe (i.e., Alpha wipes). In summary, using either Whatman or Alpha wipes, the mean recovery of pyrene from the UGEO that was applied to the hands and contained within three consecutive wipes was 69% and 54%, respectively. However, the relative recovery of the first to second wipe was on average 47% and 75% for the two media, respectively. These results indicate that the Alpha wipes were more efficient at recovering pyrene in the first wipe but less efficient overall when all three consecutive samples were included. Even though this sampling was performed in a controlled laboratory environment, the minimum and maximum amount of pyrene recovered in the individual composite samples using either method spanned a range of twofold. Overall, intra-and interpersonal variability, as measured by coefficient of variation, were 22% and 19%, respectively, and were not statistically different by type of media used. This method was used in a pilot field survey to sample the hands of 18 automotive repair technicians and 18 office workers. Detectable amounts of pyrene (>0.2 microg/sample) were found on the hands of 61% and 0% of these two groups, respectively, with the highest measured quantity equal to 1.06 microg. Samples from the upper surfaces of automobile motors were generally low to nondetectable (<0.027 microg/sample), while the median value of 0.047 mkcrlg/50 cm(2)(CV = 160%) and up to 0.640 microg were found on the drip pans.
SN - 1545-9624
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; mboeniger@cinci.rr.com
U2 - PMID: 18464095.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105695163&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105695172
T1 - Presence of airborne fibers in tungsten refining and manufacturing processes: preliminary characterization [corrected] [published erratum appears in J OCCUP ENVIRON HYG 2008 Aug;5(8):D95].
AU - McKernan JL
AU - Toraason MA
AU - Fernback JE
Y1 - 2008/07//
N1 - Accession Number: 105695172. Language: English. Entry Date: 20081121. Revision Date: 20150711. Publication Type: Journal Article; diagnostic images; equations & formulas; research; tables/charts. Note: For CE see Suppl pages D77-9. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: National Toxicology Program; with the National Institute for Occupational Safety and Health (Interagency Agreement #Y1-ES-9045-10). NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Metals -- Analysis
KW - Occupational Exposure -- Analysis
KW - Air Pollutants, Occupational -- Adverse Effects
KW - Air Pollution, Indoor -- Adverse Effects
KW - Air Pollution, Indoor -- Analysis
KW - Education, Continuing (Credit)
KW - Environmental Exposure -- Adverse Effects
KW - Environmental Monitoring -- Methods
KW - Filtration
KW - Funding Source
KW - Lung Diseases -- Chemically Induced
KW - Metallurgy
KW - Metals -- Adverse Effects
KW - Microscopy, Electron
KW - Minerals -- Adverse Effects
KW - Minerals -- Analysis
KW - National Institute for Occupational Safety and Health
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Exposure -- Standards
KW - Probability
KW - United States
KW - Human
SP - 463
EP - 474
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In tungsten refining and manufacturing processes, a series of tungsten oxides (WOX) are typically formed as intermediates in the production of tungsten powder. Studies in the Swedish tungsten refining and manufacturing industry have shown that intermediate tungsten refining processes can create WOX fibers. The purpose of the present study was to identify and provide a preliminary characterization of airborne tungsten-containing fiber dimensions, elemental composition, and concentrations in the U.S. tungsten refining and manufacturing industry. To provide the preliminary characterization, 10 static air samples were collected during the course of normal employee work activities and analyzed using standard fiber sampling and counting methods. Results from transmission electron microscopy analyses conducted indicate that airborne fibers with length > 0.5 micro m, diameter > 0.01 micro m, and aspect ratio greater than or equal to 3:1, with a geometric mean (GM) length of -2.0 micro m and GM diameter of -0.25 micro m, were present on 9 of the 10 air samples collected. Energy dispersive X-ray spectrometry results indicate that airborne fibers prior to the carburization process consisted primarily of tungsten and oxygen, with other elements being detected in trace quantities. Results from an air sample collected at the carburization process indicated the presence of fibers composed primarily of tungsten with oxygen and carbon, and traces of other elements. Based on National Institute for Occupational Safety and Health standard fiber counting rules, airborne fiber concentrations ranged from below the limit of detection to 0.14 f/cm3. The calcining process was associated with the highest airborne fiber concentrations. More than 99% (574/578) of the airborne fibers identified had an aerodynamic diameter less than or equal to 10 micro m, indicating that they were capable of reaching the thoracic regions. Until more is known about the durability and potential health effects associated with airborne tungsten-containing fibers, it would be prudent to take steps to limit or eliminate occupational exposures.
SN - 1545-9624
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 18569509.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105695172&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yeon-Soon Ahn
AU - Park, Robert M.
AU - Dong-Hee Koh
T1 - Cancer Admission and Mortality in Workers Exposed to Ionizing Radiation in Korea.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/07//
VL - 50
IS - 7
M3 - Article
SP - 791
EP - 803
SN - 10762752
AB - The article reports on the result of the study which assesses the level of cancer mortality and morbidity among employees exposed to ionizing radiation in Korea. The study has evaluated radiation exposure data of employees admitted to hospitals based on the Standardized Rate Ratios (SRR) and Standardized Mortality Ratios (SMR) through Poisson regression analysis. It reveals that hospitalization of cancer patients was low from 2000-2005. It shows that thyroid cancer was high among women employed in medical institutions, research institutions, and nuclear power plants. It was found that excess relative risk (ERR) was 300 per Sieverts among workers exposed to ionizing radiation.
KW - CANCER -- Mortality
KW - MORTALITY
KW - OCCUPATIONAL mortality
KW - IONIZING radiation
KW - RADIATION
KW - THYROID cancer
KW - CANCER in women
KW - OCCUPATIONAL diseases
KW - HOSPITALS -- Admission & discharge
KW - REGRESSION analysis
KW - INDUSTRIAL hygiene
KW - KOREA
N1 - Accession Number: 33399726; Yeon-Soon Ahn 1 Park, Robert M. 2; Email Address: rhp9@cdc.gov Dong-Hee Koh 3; Affiliation: 1: Department of Occupational Medicine, Dongguk University International Hospital, Dongguk University College of Medicine, Goyang, Korea 2: Risk Evaluation Branch, Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea; Source Info: Jul2008, Vol. 50 Issue 7, p791; Subject Term: CANCER -- Mortality; Subject Term: MORTALITY; Subject Term: OCCUPATIONAL mortality; Subject Term: IONIZING radiation; Subject Term: RADIATION; Subject Term: THYROID cancer; Subject Term: CANCER in women; Subject Term: OCCUPATIONAL diseases; Subject Term: HOSPITALS -- Admission & discharge; Subject Term: REGRESSION analysis; Subject Term: INDUSTRIAL hygiene; Subject Term: KOREA; Number of Pages: 13p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1097/JOM.0b013e318167751d
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33399726&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105701995
T1 - The stability of the oxidative stress marker, urinary 8-hydroxy-2'- deoxyguanosine (8-OHdG), when stored at room temperature.
AU - Matsumoto Y
AU - Ogawa Y
AU - Yoshida R
AU - Shimamori A
AU - Kasai H
AU - Ohta H
Y1 - 2008/07//2008 Jul
N1 - Accession Number: 105701995. Language: English. Entry Date: 20081128. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Asia; Biomedical. NLM UID: 9616320.
KW - Deoxyribonucleosides
KW - Drug Storage
KW - Oxidative Stress
KW - Temperature
KW - Adult
KW - Deoxyribonucleosides -- Analysis
KW - Deoxyribonucleosides -- Pharmacokinetics
KW - Deoxyribonucleosides -- Urine
KW - Drug Stability
KW - Female
KW - Interviews
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Specimen Handling
KW - Human
SP - 366
EP - 372
JO - Journal of Occupational Health
JF - Journal of Occupational Health
JA - J OCCUP HEALTH
VL - 50
IS - 4
PB - Kyorinsha
SN - 1341-9145
AD - National Institute of Occupational Safety and Health, Kawasaki, Japan.
U2 - PMID: 18560203.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105701995&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105785876
T1 - Strengthening public health ethics at the Centers for Disease Control and Prevention.
AU - Barrett DH
AU - Bernier RH
AU - Sowell AL
Y1 - 2008/07//Jul/Aug2008
N1 - Accession Number: 105785876. Language: English. Entry Date: 20080808. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9505213.
KW - Centers for Disease Control and Prevention (U.S.)
KW - Public Health -- Ethical Issues
KW - Leadership
KW - United States
SP - 348
EP - 353
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 14
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - In early 2005, the Centers for Disease Control and Prevention (CDC) launched an initiative to strengthen leadership in public health ethics. This resulted in the formation of an external Ethics Subcommittee of the Advisory Committee to the Director, an internal CDC Public Health Ethics Committee, and the creation of a new position, the CDC Public Health Ethics Coordinator, to oversee the activities of these two committees and to serve as the main point of contact for public health ethics at the agency. Through this effort, the CDC is collaborating with the Ethics Subcommittee to develop ethical guidance documents that address specific public health program concerns, including pandemic influenza, emergency preparedness and response, and genomics. It is anticipated that as the public health ethics activities grow within the CDC, benefits will be seen in greater participation and partnership with affected stakeholders and strengthened public trust in health recommendations.
SN - 1078-4659
AD - US Public Health Service, Public Health Ethics Coordinator, Office of the Chief Science Officer, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop D-50, Atlanta, GA 30333; DBarrett@cdc.gov
U2 - PMID: 18552645.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105785876&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Mothers and Children Benefit from Breastfeeding
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2008/07//
VL - 108
IS - 7
M3 - Editorial
SP - 1106
EP - 1106
SN - 00028223
N1 - Accession Number: 32844055; Galson, Steven K. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Jul2008, Vol. 108 Issue 7, p1106; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2008.04.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bergstrom, Nancy
AU - Smout, Randall
AU - Horn, Susan
AU - Spector, William
AU - Hartz, Arthur
AU - Limcangco, M. Rhona
T1 - Stage 2 Pressure Ulcer Healing in Nursing Homes.
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
Y1 - 2008/07//
VL - 56
IS - 7
M3 - Article
SP - 1252
EP - 1258
PB - Wiley-Blackwell
SN - 00028614
AB - OBJECTIVES: To identify resident and wound characteristics associated with Stage 2 pressure ulcer (PrU) healing time in nursing home residents. DESIGN: Retrospective cohort study with convenience sampling. SETTING: One hundred two nursing homes participating in the National Pressure Ulcer Long-Term Care Study (NPULS) in the United States. PARTICIPANTS: Seven hundred seventy-four residents aged 21 and older with length of stay of 14 days or longer who had at least one initial Stage 2 (hereafter Stage 2) PrU. MEASUREMENTS: Data collected for each resident over a 12-week period included resident characteristics and PrU characteristics, including area when first reached Stage 2. Data were obtained from medical records and logbooks. RESULTS: There were 1,241 initial Stage 2 PrUs on 774 residents; 563 (45.4%) healed. Median time to heal was 46 days. Initial area was significantly associated with days to heal. Using Kaplan-Meier survival analyses, median days to heal was 33 for small (≤1 cm2), 53 days for medium (>1 to ≤4 cm2), and 73 days for large (>4 cm2) ulcers. Using Cox proportional hazard regression models to examine effects of multiple variables simultaneously, small and medium ulcers and ulcers on residents with agitation and those who had oral eating problem healed more quickly, whereas ulcers on residents who required extensive assistance with seven to eight activities of daily living (ADLs), who temporarily left the facility for the emergency department (ED) or hospital, or whose PrU was on an extremity healed more slowly. CONCLUSION: PrUs on residents with agitation or with oral eating problems were associated with faster healing time. PrUs located on extremities, on residents who went temporarily to the ED or hospital, and on residents with high ADL disabilities were associated with slower healing time. Interaction between PrU size and place of onset was also associated with healing time. For PrU onset before or after admission to the facility, smaller size was associated with faster healing time. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BEDSORES
KW - SURGERY
KW - ULCERS
KW - NURSING home patients
KW - WOUND healing
KW - long-term care
KW - nursing homes
KW - pressure ulcers
KW - survival analysis
N1 - Accession Number: 33388870; Bergstrom, Nancy 1 Smout, Randall 2 Horn, Susan 2 Spector, William 3 Hartz, Arthur 4 Limcangco, M. Rhona 5; Affiliation: 1: Center on Aging, School of Nursing, University of Texas at Houston, Houston, Texas; 2: Institute for Clinical Outcomes Research, Salt Lake City, Utah; 3: Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland; 4: Huntsman Cancer Institute, School of Medicine, University of Utah, Salt Lake City, Utah; and 5: Social & Scientific Systems, Inc., Rockville, Maryland; Source Info: Jul2008, Vol. 56 Issue 7, p1252; Subject Term: BEDSORES; Subject Term: SURGERY; Subject Term: ULCERS; Subject Term: NURSING home patients; Subject Term: WOUND healing; Author-Supplied Keyword: long-term care; Author-Supplied Keyword: nursing homes; Author-Supplied Keyword: pressure ulcers; Author-Supplied Keyword: survival analysis; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1111/j.1532-5415.2008.01765.x
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Glaser, John1, jglaser@partners.org
AU - Heenley, Douglas E.2
AU - Downing, Gregory3
AU - Brinner, Kristin M.4
T1 - Advancing Personalized Health Care through Health Information Technology: An Update from the American Health Information Community's Personalized Health Care Workgroup.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2008/07//Jul/Aug2008
Y1 - 2008/07//Jul/Aug2008
VL - 15
IS - 4
CP - 4
M3 - Article
SP - 391
EP - 396
SN - 10675027
AB - The Personalized Health Care Workgroup of the American Health Information Community was formed to determine what is needed to promote standard reporting and incorporation of medical genetic/genomic tests and family health history data in electronic health records. The Workgroup has examined and clarified a range of issues related to this information, including interoperability standards and requirements for confidentiality, privacy, and security, in the course of developing recommendations to facilitate its capture, storage, transmission, and use in clinical decision support. The Workgroup is one of several appointed by the American Health Information Community to study high-priority issues related to the implementation of interoperable electronic health records in the United States. It is also a component of the U.S. Department of Health and Human Services' Personalized Health Care Initiative, which is designed to create a foundation upon which information technology that supports personalized, predictive, and pre-emptive health care can be built. [ABSTRACT FROM AUTHOR]
KW - Electronic health records
KW - Information storage & retrieval systems -- Medical care
KW - Medical history taking
KW - Multidimensional Health Profile
KW - Electronic records -- Access control -- United States
KW - United States. Dept. of Health & Human Services
KW - United States
N1 - Accession Number: 33142909; Authors: Glaser, John 1 Email Address: jglaser@partners.org; Heenley, Douglas E. 2; Downing, Gregory 3; Brinner, Kristin M. 4; Affiliations: 1: HealthCare, Boston, MA; 2: American Academy of Family Physicians, Leawood, KS.; 3: Personalized Health Care Initiative, United States Department of Health and Human Services, Washington, DC.; 4: Personalized Health Care Workgroup, American Health Information Community, United States Department of Health and Human Services, Washington, DC.; Subject: Electronic health records; Subject: Information storage & retrieval systems -- Medical care; Subject: Medical history taking; Subject: Multidimensional Health Profile; Subject: United States. Dept. of Health & Human Services; Subject: Electronic records -- Access control -- United States; Subject: United States; Number of Pages: 6p; Illustrations: 1 Chart; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 105673358
T1 - Drug-risk communication to pharmacists: assessing the impact of risk-minimization strategies on the practice of pharmacy.
AU - Lee LY
AU - Kortepeter CM
AU - Willy ME
AU - Nourjah P
Y1 - 2008/07//Jul/Aug2008
N1 - Accession Number: 105673358. Language: English. Entry Date: 20081024. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101176252.
KW - Drugs -- Adverse Effects
KW - Pharmacists -- Administration
KW - Pharmacy Service -- Administration
KW - Risk Management -- Methods
KW - Attitude to Health
KW - Communication
KW - Cross Sectional Studies
KW - Data Collection
KW - Professional Role
KW - United States
KW - Human
SP - 494
EP - 500
JO - Journal of the American Pharmacists Association: JAPhA
JF - Journal of the American Pharmacists Association: JAPhA
JA - J AM PHARM ASSOC
VL - 48
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1544-3191
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. lauren.lee@fda.hhs.gov
U2 - PMID: 18653425.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yuasa, K.
AU - Kumasaki, M.
AU - Mizutani, T.
AU - Arai, M.
T1 - Thermal hazard evaluation procedure for detoxifying system of hazardous gases by using of reaction calorimeter.
JO - Journal of Thermal Analysis & Calorimetry
JF - Journal of Thermal Analysis & Calorimetry
Y1 - 2008/07//
VL - 93
IS - 1
M3 - Article
SP - 41
EP - 45
PB - Springer Science & Business Media B.V.
SN - 13886150
AB - The thermal behaviors of hazardous gas adsorbents were observed using a C80 calorimeter in order to develop a comprehensive thermal hazard evaluation procedure for a hazardous gas detoxifying system. Newly modified cells for the C80 were used to simultaneously monitor the pressure and the heat flow. The cells were also available for adsorbed gas switching. Adsorption/desorption experiments showed various thermal behaviors of the different gas-adsorbent combinations. The accidental incorporation of air into the cartridges proved to be a potential risk for heat generation. In addition, two kinds of experimental results in different states, static pressure and gas-circulation, were compared. As a result, the experimental apparatus used in this study exhibited the capability of evaluating the thermal hazards under the situation of accidental contamination by either air or other undesirable gases as well as normal adsorption. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Thermal Analysis & Calorimetry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALORIMETERS
KW - ADSORPTION
KW - THERMAL desorption
KW - COMBINATORIAL analysis
KW - GAS research
KW - adsorption process
KW - C80
KW - dry detoxifying adsorbent
KW - hazard evaluation
N1 - Accession Number: 32852888; Yuasa, K. 1; Email Address: yuasa@explosion.chem.t-u-tokyo.ac.jp Kumasaki, M. 2 Mizutani, T. 2 Arai, M. 3; Affiliation: 1: Graduate School of Engineering, Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 Japan 2: National Institute of Occupational Safety and Health, 1-4-6 Umezono, Kiyose Tokyo 204-0024, Japan 3: Environmental Science Center, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033, Japan; Source Info: Jul2008, Vol. 93 Issue 1, p41; Subject Term: CALORIMETERS; Subject Term: ADSORPTION; Subject Term: THERMAL desorption; Subject Term: COMBINATORIAL analysis; Subject Term: GAS research; Author-Supplied Keyword: adsorption process; Author-Supplied Keyword: C80; Author-Supplied Keyword: dry detoxifying adsorbent; Author-Supplied Keyword: hazard evaluation; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 5p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s10973-007-8777-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32852888&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105551993
T1 - U.S. Food and Drug Administration and off-label use of expandable metal biliary stents within the peripheral vasculature.
AU - Yustein AS
AU - Schultz D
AU - Neuland C
AU - Buckles DS
AU - Nipper JC
AU - Stephenson RA
AU - Gonzalez G
Y1 - 2008/07//
N1 - Accession Number: 105551993. Language: English. Entry Date: 20090626. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 9203369.
KW - Biliary Tract Surgical Procedures -- Equipment and Supplies
KW - Device Approval -- Legislation and Jurisprudence
KW - Metals
KW - Stents
KW - Surgery, Cardiovascular -- Equipment and Supplies
KW - Biliary Tract Surgical Procedures -- Adverse Effects
KW - Biliary Tract Surgical Procedures -- Legislation and Jurisprudence
KW - Consumer Product Safety
KW - Government Regulations
KW - Guideline Adherence
KW - Practice Guidelines
KW - Product Evaluation
KW - Prosthesis Design
KW - Prosthesis Failure
KW - Surgery, Cardiovascular -- Adverse Effects
KW - Surgery, Cardiovascular -- Legislation and Jurisprudence
KW - United States
SP - 965
EP - 969
JO - Journal of Vascular & Interventional Radiology
JF - Journal of Vascular & Interventional Radiology
JA - J VASC INTERVENT RADIOL
VL - 19
IS - 7
CY - New York, New York
PB - Elsevier Science
SN - 1051-0443
AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, 9200 Corporate Boulevard, Rockville, MD 20850, USA. aron.yustein@fda.hhs.gov
U2 - PMID: 18672491.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105551993&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chih-Yun Lai
AU - Wen-Yang Tsai
AU - Su-Ru Lin
AU - Chuan-Liang Kao
AU - Hsien-Ping Hu
AU - Chwan-Chuen King
AU - Han-Chung Wu
AU - Gwong-Jen Chang
AU - Wei-Kung Wang
T1 - Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008/07//
VL - 82
IS - 13
M3 - Article
SP - 48
EP - 48
SN - 0022538X
AB - The antibody response to the envelope (E) glycoprotein of dengue virus (DENV) is known to play a critical role in both protection from and enhancement of disease, especially after primary infection. However, the relative amounts of homologous and heterologous anti-E antibodies and their epitopes remain unclear. In this study, we examined the antibody responses to E protein as well as to precursor membrane (PrM), capsid, and nonstructural protein 1 (NS1) of four serotypes of DENV by Western blot analysis of DENV serotype 2-infected patients with different disease severity and immune status during an outbreak in southern Taiwan in 2002. Based on the early-convalescent-phase sera tested, the rates of antibody responses to PrM and NS1 proteins were significantly higher in patients with secondary infection than in those with primary infection. A blocking experiment and neutralization assay showed that more than 90% of anti-E antibodies after primary infection were cross-reactive and nonneutralizing against heterologous serotypes and that only a minor proportion were type specific, which may account for the type-specific neutralization activity. Moreover, the E-binding activity in sera of 10 patients with primary infection was greatly reduced by amino acid replacements of three fusion loop residues, tryptophan at position 101, leucine at position 107, and phenylalanine at position 108, but not by replacements of those outside the fusion loop of domain II, suggesting that the predominantly cross-reactive anti-E antibodies recognized epitopes involving the highly conserved residues at the fusion loop of domain II. These findings have implications for our understanding of the pathogenesis of dengue and for the future design of subunit vaccine against DENV as well. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - GLYCOPROTEINS
KW - DENGUE viruses
KW - ANTIGENIC determinants
KW - SERUM
KW - BLOOD plasma
KW - VACCINATION
KW - PREVENTIVE medicine
N1 - Accession Number: 33113126; Chih-Yun Lai 1 Wen-Yang Tsai 1 Su-Ru Lin 1 Chuan-Liang Kao 2 Hsien-Ping Hu 1 Chwan-Chuen King 3 Han-Chung Wu 4 Gwong-Jen Chang 5 Wei-Kung Wang 1,6; Email Address: wwang60@yahoo.com; Affiliation: 1: Institute of Microbiology 2: Institute of Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan 3: Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 4: Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan 5: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 6: Department of Internal Medicine, National Taiwan University, Taipei, Taiwan; Source Info: Jul2008, Vol. 82 Issue 13, p48; Subject Term: IMMUNOGLOBULINS; Subject Term: GLYCOPROTEINS; Subject Term: DENGUE viruses; Subject Term: ANTIGENIC determinants; Subject Term: SERUM; Subject Term: BLOOD plasma; Subject Term: VACCINATION; Subject Term: PREVENTIVE medicine; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.00316-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105645651
T1 - Changes in hospital readmissions for diabetes-related conditions: differences by payer.
AU - Jiang HJ
AU - Friedman B
AU - Andrews R
Y1 - 2008/07//2008 Jul
N1 - Accession Number: 105645651. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9715194.
KW - Diabetes Mellitus -- Complications
KW - Quality of Health Care
KW - Readmission -- Trends
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Chi Square Test
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Logistic Regression
KW - Male
KW - Medicaid
KW - Middle Age
KW - Odds Ratio
KW - P-Value
KW - Human
SP - 24
EP - 31
JO - Managed Care Interface
JF - Managed Care Interface
JA - MANAGE CARE INTERFACE
VL - 21
IS - 1
CY - Bronxville NEW YORK 10708, New York
PB - Medicom International Incorporated
SN - 1096-5645
AD - Senior Social Scientist, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Maryland 20850; joanna.jiang@ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn
T1 - H-CAHPS survey reflects patient experiences.
JO - Managed Healthcare Executive
JF - Managed Healthcare Executive
Y1 - 2008/07//
VL - 18
IS - 7
M3 - Article
SP - 34
EP - 34
PB - Advanstar Communications Inc.
SN - 15339300
AB - The article focuses on the benefits of the Hospital Consumer Assessment of Healthcare Providers and Systems (H-CAHPS) survey on reporting consumers' experience with health plans in the U.S. The survey is used by public and private employers, Medicaid and other entities to tackle health issues. It aims to provide data that will be beneficial to patient as it provides information in decision making.
KW - CUSTOMER satisfaction
KW - MEDICAL care
KW - DECISION making
KW - SURVEYS
KW - HEALTH planning
KW - UNITED States
N1 - Accession Number: 33142213; Clancy, Carolyn 1; Affiliations: 1: Director of the U.S. Agency for Healthcare Research and Quality; Issue Info: Jul2008, Vol. 18 Issue 7, p34; Thesaurus Term: CUSTOMER satisfaction; Thesaurus Term: MEDICAL care; Thesaurus Term: DECISION making; Subject Term: SURVEYS; Subject Term: HEALTH planning; Subject: UNITED States; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Wang, Cheng
AU - Sadovova, Natalya
AU - Patterson, Tucker A.
AU - Zou, Xiaoju
AU - Fu, Xin
AU - Hanig, Joseph P.
AU - Paule, Merle G.
AU - Ali, Syed F.
AU - Zhang, Xuan
AU - Slikker, William
T1 - Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2008/07//
VL - 29
IS - 4
M3 - Article
SP - 613
EP - 620
SN - 0161813X
AB - Abstract: Ketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, is used as a pediatric anesthetic for surgical procedures. Recent data suggest that anesthetic drugs may cause neurodegeneration during development. The purpose of this study was to determine the dose and temporal response of ketamine using newborn rat forebrain cultures and also to determine if co-administration of 7-nitroindazole, a nitric oxide synthase (NOS) inhibitor, could protect or reverse ketamine-induced cell death. Neural cells collected from the rat forebrain were incubated for 24h with 1, 10 or 20μM ketamine alone or with ketamine plus 1, 5, 10 or 20μM 7-nitroindazole. Ketamine (10μM) caused an increase in DNA fragmentation and elevated immunoreactivity to nitrotyrosine, a marked reduction in the expression of the neuronal marker polysialic acid neural cell adhesion molecule (PSA-NCAM) and in mitochondrial metabolism, as well as an increased Bax/BCL-XL ratio. No significant effect was observed in the release of lactate dehydrogenase (LDH). Ketamine-induced neurotoxic effects were effectively blocked by 7-nitroindazole (10μM). These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KETAMINE
KW - METHYL aspartate
KW - PEDIATRIC anesthesia
KW - PEDIATRIC surgery
KW - CELL death
KW - CELL adhesion molecules
KW - NITRIC oxide
KW - Apoptosis
KW - N-Methyl-d-aspartate
KW - Neurodegeneration
KW - Neuroprotection
KW - Nitric oxide
KW - nNOS
N1 - Accession Number: 32981578; Wang, Cheng 1; Email Address: cheng.wang@fda.hhs.gov Sadovova, Natalya 2 Patterson, Tucker A. 1 Zou, Xiaoju 1 Fu, Xin 3 Hanig, Joseph P. 4 Paule, Merle G. 1 Ali, Syed F. 1 Zhang, Xuan 1 Slikker, William 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food & Drug Administration, HFT-132 Jefferson, AR, USA 2: Toxicologic Pathology Associates, Jefferson, AR, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research/U.S. Food & Drug Administration, Jefferson, AR, USA 4: Center for Drug Evaluation and Research/U.S. Food & Drug Administration, Silver Spring, MD, USA; Source Info: Jul2008, Vol. 29 Issue 4, p613; Subject Term: KETAMINE; Subject Term: METHYL aspartate; Subject Term: PEDIATRIC anesthesia; Subject Term: PEDIATRIC surgery; Subject Term: CELL death; Subject Term: CELL adhesion molecules; Subject Term: NITRIC oxide; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: N-Methyl-d-aspartate; Author-Supplied Keyword: Neurodegeneration; Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: nNOS; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.neuro.2008.03.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davis, Rickie R.
T1 - What do we know about hearing protector comfort?
JO - Noise & Health
JF - Noise & Health
Y1 - 2008/07//
VL - 10
IS - 40
M3 - Article
SP - 83
EP - 89
SN - 14631741
AB - The purpose of the present article is to review comfort studies on hearing protector devices. Comfort is probably the most important dimension for long-term worker acceptance and effective wear of hearing protectors in noise. A short digression has been made to introduce comfort work from the textile and clothing industries where models of comfort have been attempted and comfort research is much more sophisticated. Finally, presented are some recent efforts by NIOSH to examine issues of hearing protector comfort in greater detail. These efforts include a field study of a semicustom earplug hearing protector. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise & Health is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOISE control -- Equipment & supplies
KW - NOISE
KW - TEXTILE industry
KW - CLOTHING industry
KW - UNITED States
KW - Comfort
KW - hearing protectors
KW - personal protective equipment
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 35793584; Davis, Rickie R. 1; Email Address: rrd1@cdc.gov; Affiliation: 1: Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226 USA; Source Info: 2008, Vol. 10 Issue 40, p83; Subject Term: NOISE control -- Equipment & supplies; Subject Term: NOISE; Subject Term: TEXTILE industry; Subject Term: CLOTHING industry; Subject Term: UNITED States; Author-Supplied Keyword: Comfort; Author-Supplied Keyword: hearing protectors; Author-Supplied Keyword: personal protective equipment; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 448199 All other clothing stores; NAICS/Industry Codes: 448140 Family Clothing Stores; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 448190 Other Clothing Stores; NAICS/Industry Codes: 424310 Piece Goods, Notions, and Other Dry Goods Merchant Wholesalers; NAICS/Industry Codes: 414130 Piece goods, notions and other dry goods merchant wholesalers; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105585728
T1 - What do we know about hearing protector comfort?
AU - Davis RR
Y1 - 2008/07//
N1 - Accession Number: 105585728. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Asia; Biomedical. Special Interest: Speech-Language Pathology/Audiology. NLM UID: 9815620.
KW - Ear Protective Devices -- Standards
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Consumer Satisfaction
KW - Equipment Design
KW - National Institute for Occupational Safety and Health
KW - Occupational Health
KW - United States
SP - 83
EP - 89
JO - Noise & Health
JF - Noise & Health
JA - NOISE HEALTH
VL - 10
IS - 40
PB - Medknow Publications & Media Pvt. Ltd.
SN - 1463-1741
AD - Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. rrd1@cdc.gov.
U2 - PMID: 19052440.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105585728&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - State Ranks of Incident Cancer Burden due to Overweight and Obesity in the United States, 2003.
AU - Shine Chang
AU - Mâsse, Louise C.
AU - Moser, Richard P.
AU - Dodd, Kevin W.
AU - Arganaraz, Facundo
AU - Fuemmler, Bernard F.
AU - Jemal, Ahmedin
JO - Obesity (19307381)
JF - Obesity (19307381)
Y1 - 2008/07//
VL - 16
IS - 7
SP - 1636
EP - 1650
SN - 19307381
N1 - Accession Number: 33311389; Author: Shine Chang: 1,2 email: ShineChang@MDAnderson.org. Author: Mâsse, Louise C.: 3,4 Author: Moser, Richard P.: 5 Author: Dodd, Kevin W.: 6 Author: Arganaraz, Facundo: 1,3,7 Author: Fuemmler, Bernard F.: 1,3,8 Author: Jemal, Ahmedin: 9 ; Author Affiliation: 1 Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA: 2 The University of Texas M. D. Anderson Cancer Center in the Department of Epidemiology, Houston, Texas, USA: 3 Health Promotion Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA: 4 University of British Columbia, Centre for Community Child Health Research, Vancouver, British Colombia, Canada: 5 Office of the Associate Director of the Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA: 6 Biometry Research Branch, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA: 7 Alexander Fleming Institute, Capital Federal, Buenos Aires, Argentina: 8 Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA: 9 Epidemiology and Surveillance Research Department, the American Cancer Society, Atlanta, Georgia, USA; No. of Pages: 15; Language: English; Publication Type: Article; Update Code: 20150711
N2 - This article presents a study that investigated incident cancer burden due to overweight and obesity at the state level in the U.S. Data on state rankings by per capita burden of incident cancer due to overweight and obesity in 2003 was used in this study. Results showed that the lowest weight-related cancer burden for both sexes can be seen in the Western states. The study also found that West Virginia is the only state that ranked in the quintile of highest weight-related burden for all cancers considered in women.
KW - *CANCER
KW - *OBESITY
KW - *BODY weight
KW - DISEASE incidence
KW - U.S. states
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 105673949
T1 - State ranks of incident cancer burden due to overweight and obesity in the United States, 2003.
AU - Chang S
AU - Mâsse LC
AU - Moser RP
AU - Dodd KW
AU - Arganaraz F
AU - Fuemmler BF
AU - Jemal A
Y1 - 2008/07//
N1 - Accession Number: 105673949. Language: English. Entry Date: 20080926. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. NLM UID: 101264860.
KW - Neoplasms -- Epidemiology
KW - Neoplasms -- Etiology
KW - Obesity -- Complications
KW - Obesity -- Epidemiology
KW - Adult
KW - Census
KW - Cross Sectional Studies
KW - Female
KW - Incidence
KW - Male
KW - Prevalence
KW - Registries, Disease
KW - Residence Characteristics
KW - Risk Assessment
KW - Risk Factors
KW - United States
KW - Human
SP - 1636
EP - 1650
JO - Obesity (19307381)
JF - Obesity (19307381)
JA - OBESITY (19307381)
VL - 16
IS - 7
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1930-7381
AD - Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA. Shine.Chang@MDAnderson.org
U2 - PMID: 18421271.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105673949&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Deddens, J. A.
AU - Petersen, M. R.
T1 - Approaches for estimating prevalence ratios.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2008/07//
VL - 65
IS - 7
M3 - Article
SP - 501
EP - 506
SN - 13510711
AB - The article reviews existing methods and provides examples and recommendations on how to estimate prevalence risk. It examines methods such as logistic regression for modelling binomial health outcomes, the Cox proportional hazard method, the Poisson regression, the COPY method and the maximum likelihood estimates. It suggests that the odds ratio (logistic regression) is not suitable for the approximation of the prevalence ratio of common outcomes. The COPY method can be used to find the approximate maximum likelihood solution to the log-binomial model.
KW - Disease prevalence
KW - Diseases
KW - RESEARCH
KW - Reporting of diseases
KW - Epidemiology
KW - Logistic regression analysis
KW - Binomial distribution
KW - Medical statistics
KW - Poisson distribution
KW - Estimation theory
N1 - Accession Number: 32929545; Deddens, J. A. 1,2; Email Address: jad0@cdc.gov; Petersen, M. R. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio, USA; Issue Info: Jul2008, Vol. 65 Issue 7, p501; Thesaurus Term: Disease prevalence; Thesaurus Term: Diseases; Thesaurus Term: RESEARCH; Thesaurus Term: Reporting of diseases; Thesaurus Term: Epidemiology; Subject Term: Logistic regression analysis; Subject Term: Binomial distribution; Subject Term: Medical statistics; Subject Term: Poisson distribution; Subject Term: Estimation theory; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1136/oem.2007.034777
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32929545&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105780070
T1 - Approaches for estimating prevalence ratios.
AU - Deddens JA
AU - Petersen MR
Y1 - 2008/07//
N1 - Accession Number: 105780070. Language: English. Entry Date: 20080801. Revision Date: 20161122. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 9422759.
KW - Models, Statistical
KW - Occupational Diseases -- Epidemiology
KW - Occupational Health
KW - Prevalence
SP - 501
EP - 506
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 65
IS - 7
PB - BMJ Publishing Group
SN - 1351-0711
AD - National Institute for Occupational Safety and Health, Mail Stop R15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. jad0@cdc.gov
U2 - PMID: 18562687.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105780070&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CONF
AU - Galson, Steven K.
T1 - PREVENTION OF DEEP VEIN THROMBOSIS AND PULMONARY EMBOLISM.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/07//Jul/Aug2008
VL - 123
IS - 4
M3 - Proceeding
SP - 420
EP - 421
SN - 00333549
AB - The article offers information on the "Surgeon General's Workshop on Deep Vein Thrombosis (DVT)" hosted by the former U.S. surgeon general Richard H. Carmona in conjunction with the National Heart Lung and Blood Institute. The meeting aims to raise awareness about DVT and Pulmonary Embolism (PE). Other relevant information about the topics discussed is provided.
KW - CONFERENCES & conventions
KW - MEDICINE -- Congresses
KW - PULMONARY embolism
KW - THROMBOSIS
KW - NATIONAL Heart Lung & Blood Institute
KW - CARMONA, Richard H., 1949-
N1 - Accession Number: 32817878; Galson, Steven K. 1; Affiliation: 1: RADM, United States Surgeon General U.S. Public Health Service; Source Info: Jul/Aug2008, Vol. 123 Issue 4, p420; Subject Term: CONFERENCES & conventions; Subject Term: MEDICINE -- Congresses; Subject Term: PULMONARY embolism; Subject Term: THROMBOSIS; Company/Entity: NATIONAL Heart Lung & Blood Institute; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; People: CARMONA, Richard H., 1949-; Number of Pages: 2p; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Lutter, Randall
AU - McConagha, William A.
T1 - THE FDA RESPONDS.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/07//Jul/Aug2008
VL - 123
IS - 4
M3 - Letter
SP - 422
EP - 423
SN - 00333549
AB - A letter to the editor is presented in response to the article "Increasing Transparency at the FDA: The Impact of the FDA Amendments Act of 2007," by Susan Wood and Kristen L. Perosino which appeared in the July 1, 2008 issue.
KW - LETTERS to the editor
KW - PUBLIC health laws
N1 - Accession Number: 32817879; Lutter, Randall 1 McConagha, William A. 1; Affiliation: 1: Food and Drug Administration, Department of Health and Human Services, Washington, DC; Source Info: Jul/Aug2008, Vol. 123 Issue 4, p422; Subject Term: LETTERS to the editor; Subject Term: PUBLIC health laws; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105775929
T1 - Surgeon General's perspective. Prevention of deep vein thrombosis and pulmonary embolism.
AU - Galson SK
Y1 - 2008/07//Jul/Aug2008
N1 - Accession Number: 105775929. Language: English. Entry Date: 20080801. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Pulmonary Embolism -- Prevention and Control
KW - Venous Thrombosis -- Prevention and Control
KW - Pulmonary Embolism -- Risk Factors
KW - Venous Thrombosis -- Risk Factors
SP - 420
EP - 421
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 123
IS - 4
PB - Sage Publications Inc.
SN - 0033-3549
AD - United States Surgeon General, U.S. Public Health Service
U2 - PMID: 18763402.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Moore, Martha M.
AU - Heflich, Robert H.
AU - Haber, Lynne T.
AU - Allen, Bruce C.
AU - Shipp, Annette M.
AU - Kodell, Ralph L.
T1 - Analysis of in vivo mutation data can inform cancer risk assessment
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2008/07//
VL - 51
IS - 2
M3 - Article
SP - 151
EP - 161
SN - 02732300
AB - Abstract: Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based on the mode-of-action (MOA) of the chemical under consideration. In particular, the risk assessment model depends on whether or not the chemical causes tumors through a direct DNA-reactive mechanism. It is assumed that direct DNA-reactive carcinogens initiate carcinogenesis by inducing mutations and have low-dose linear dose–response curves, whereas carcinogens that operate through a nonmutagenic MOA may have nonlinear dose–responses. We are currently evaluating whether the analysis of in vivo gene mutation data can inform the risk assessment process by better defining the MOA for cancer and thus influencing the choice of the low-dose extrapolation model. This assessment includes both a temporal analysis of mutation induction and a dose–response concordance analysis of mutation with tumor incidence. Our analysis of published data on riddelliine in rats and dichloroacetic acid in mice indicates that our approach has merit. We propose an experimental design and graphical analysis that allow for assessing time-to-mutation and dose–response concordance, thereby optimizing the potential for in vivo mutation data to inform the choice of the quantitative model used in cancer risk assessment. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hazardous substances
KW - Environmental protection
KW - Cancer
KW - Government policy
KW - Cancer risk assessment
KW - Mode-of-action
KW - Mutagenic carcinogen
KW - Nonmutagenic carcinogen
N1 - Accession Number: 32560677; Moore, Martha M. 1; Email Address: martha.moore@fda.hhs.gov; Heflich, Robert H. 1; Haber, Lynne T. 2; Allen, Bruce C. 3; Shipp, Annette M. 4; Kodell, Ralph L. 1; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Division of Genetic and Reproductive Toxicology, HFT-120, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Toxicology Excellence for Risk Assessment, Cincinnati, OH, USA; 3: Bruce Allen Consulting, Chapel Hill, NC, USA; 4: ENVIRON Health Sciences Institute, Ruston, LA, USA; Issue Info: Jul2008, Vol. 51 Issue 2, p151; Thesaurus Term: Hazardous substances; Thesaurus Term: Environmental protection; Subject Term: Cancer; Subject Term: Government policy; Author-Supplied Keyword: Cancer risk assessment; Author-Supplied Keyword: Mode-of-action; Author-Supplied Keyword: Mutagenic carcinogen; Author-Supplied Keyword: Nonmutagenic carcinogen; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.yrtph.2008.01.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=32560677&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Starlard-Davenport, Athena
AU - Lyn-Cook, Beverly
AU - Radominska-Pandya, Anna
T1 - Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues
JO - Steroids
JF - Steroids
Y1 - 2008/07//
VL - 73
IS - 6
M3 - Article
SP - 611
EP - 620
SN - 0039128X
AB - Abstract: UGT1A10 was recently identified as the major isoform that conjugates estrogens. In this study, real-time PCR revealed high levels of UGT1A10 and UGT2B7 mRNA in human breast tissues. The expression of UGT1A10 in breast was a novel finding. UGT1A10 and UGT2B7 mRNAs were differentially expressed among normal and malignant specimens. Their overall expression was significantly decreased in breast carcinomas as compared to normal breast specimens (UGT1A10: 68±26 vs. 252±86, respectively; p <0.05) and (UGT2B7: 1.4±0.7 vs. 12±4, respectively; p <0.05). Interestingly, in African American women, UGT1A10 expression was significantly decreased in breast carcinomas in comparison to normals (57±35 vs. 397±152, respectively; p <0.05). Among Caucasian women, UGT2B7 was significantly decreased in breast carcinomas in comparison to normals (1.1±0.5 vs. 13.5±6, respectively; p <0.05). Glucuronidation of 4-hydroxylated estrone (4-OHE1) was significantly reduced in breast carcinomas compared to normals (30±15 vs. 106±31, respectively; p <0.05). Differential down-regulation of UGT1A10 and UGT2B7 mRNAs, protein, and activity in breast carcinomas compared to the adjacent normal breast specimens from the same donor were also found. These data illustrate the novel finding of UGT1A10 in human breast and confirm the expression of UGT2B7. Significant individual variation and down-regulation of expression in breast carcinomas of both isoforms were also demonstrated. These findings provide evidence that decreased UGT expression and activity could result in the promotion of carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Steroids is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST diseases
KW - GLUCURONOSYLTRANSFERASE
KW - BREAST cancer
KW - STEROID hormones
KW - African Americans
KW - Breast cancer
KW - Caucasians
KW - UDP-glucuronosyltransferase ( UGT )
KW - UGT1A10
KW - UGTs
N1 - Accession Number: 31679310; Starlard-Davenport, Athena 1 Lyn-Cook, Beverly 2 Radominska-Pandya, Anna 1; Email Address: radominskaanna@uams.edu; Affiliation: 1: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 516, Little Rock, AR 72205, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, HFT-100 Jefferson, AR 72079, USA; Source Info: Jul2008, Vol. 73 Issue 6, p611; Subject Term: BREAST diseases; Subject Term: GLUCURONOSYLTRANSFERASE; Subject Term: BREAST cancer; Subject Term: STEROID hormones; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: Breast cancer; Author-Supplied Keyword: Caucasians; Author-Supplied Keyword: UDP-glucuronosyltransferase ( UGT ); Author-Supplied Keyword: UGT1A10; Author-Supplied Keyword: UGTs; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.steroids.2008.01.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=31679310&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Plakas, Steven M.
AU - Jester, Edward L.E.
AU - El Said, Kathleen R.
AU - Granade, Hudson R.
AU - Abraham, Ann
AU - Dickey, Robert W.
AU - Scott, Paula S.
AU - Flewelling, Leanne J.
AU - Henry, Michael
AU - Blum, Patricia
AU - Pierce, Richard
T1 - Monitoring of brevetoxins in the Karenia brevis bloom-exposed Eastern oyster (Crassostrea virginica)
JO - Toxicon
JF - Toxicon
Y1 - 2008/07//
VL - 52
IS - 1
M3 - Article
SP - 32
EP - 38
SN - 00410101
AB - Abstract: Brevetoxin uptake and elimination were examined in Eastern oyster (Crassostrea virginica) exposed to recurring blooms of the marine alga Karenia brevis in Sarasota Bay, FL, over a three-year period. Brevetoxins were monitored by in vitro assays (ELISA, cytotoxicity assay, and receptor binding assay) and LC-MS, with in vivo toxicity of shellfish extracts assessed by the traditional mouse bioassay. Measurements by all methods reflected well the progression and magnitude of the blooms. Highest levels recorded by mouse bioassay at bloom peak were 157MU/100g. Oysters were toxic by mouse bioassay at levels ≥20MU/100g for up to two weeks after bloom dissipation, whereas brevetoxins were measurable by in vitro assays and LC-MS for several months afterwards. For the structure-based methods, summed values for the principal brevetoxin metabolites of PbTx-2 (cysteine and cysteine sulfoxide conjugates), as determined by LC-MS, were highly correlated (r 2 =0.90) with composite toxin measurements by ELISA. ELISA and LC-MS values also correlated well (r 2 =0.74 and 0.73, respectively) with those of mouse bioassay. Pharmacology-based cytotoxicity and receptor binding assays did not correlate as well (r 2 =0.65), and were weakly correlated with mouse bioassay (r 2 =0.48 and 0.50, respectively). ELISA and LC-MS methods offer rapid screening and confirmation, respectively, of brevetoxin contamination in the oyster, and are excellent alternatives to mouse bioassay for assessing oyster toxicity following K. brevis blooms. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXINS
KW - RESEARCH
KW - PTYCHODISCUS brevis
KW - ENZYME-linked immunosorbent assay
KW - AMERICAN oyster
KW - RADIOLIGAND assay
KW - SARASOTA Bay (Fla.)
KW - FLORIDA
KW - Brevetoxins
KW - Eastern oyster
KW - Karenia brevis
KW - Monitoring
N1 - Accession Number: 33527527; Plakas, Steven M. 1; Email Address: steven.plakas@fda.hhs.gov Jester, Edward L.E. 1 El Said, Kathleen R. 1 Granade, Hudson R. 1 Abraham, Ann 1 Dickey, Robert W. 1 Scott, Paula S. 2 Flewelling, Leanne J. 2 Henry, Michael 3 Blum, Patricia 3 Pierce, Richard 3; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA 2: Fish and Wildlife Research Institute, 100 Eighth Avenue SE, St. Petersburg, Florida 33701, USA 3: Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, Florida 34236, USA; Source Info: Jul2008, Vol. 52 Issue 1, p32; Subject Term: TOXINS; Subject Term: RESEARCH; Subject Term: PTYCHODISCUS brevis; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: AMERICAN oyster; Subject Term: RADIOLIGAND assay; Subject Term: SARASOTA Bay (Fla.); Subject Term: FLORIDA; Author-Supplied Keyword: Brevetoxins; Author-Supplied Keyword: Eastern oyster; Author-Supplied Keyword: Karenia brevis; Author-Supplied Keyword: Monitoring; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxicon.2008.04.174
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33527527&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jian Wang
AU - Figurski, Michael
AU - Shaw, Leslie M.
AU - Burckart, Gilbert J.
T1 - The impact of P-glycoprotein and Mrp2 on mycophenolic acid levels in mice.
JO - Transplant Immunology
JF - Transplant Immunology
Y1 - 2008/07//
VL - 19
IS - 3/4
M3 - Article
SP - 192
EP - 196
PB - Elsevier Science
SN - 09663274
AB - Considerable variability has been observed in the exposure to mycophenolic acid (MPA) in transplant patients. The objective of this study was to clarify the roles of two important transporters, P-gp and Mrp2, in MPA absorption using an in vivo model. FVB strain wild-type, Mdr1a/1b-/- and Mrp2-/- mice were subjected to the administration of mycophenolate mofetil (MMF) alone or MMF in combination with cyclosporine (CsA), an immunosuppressive inhibitor of P-gp and Mrp2. At 30 mm following treatment, the MPA levels in Mdr1a/1b-/- and Mrp2-/- mice were markedly increased as compared to wild-type mice. In contrast to the reduced MPA concentrations observed at 60 and 120 mm in the CsA-treated groups, CsA produced increased mycophenolate glucuronide (MPAG) plasma levels in CsA-treated mice at each sampling time. Brain concentrations of MPA were elevated in the Mdr1a/1b-/- mice at 30 mm after MMF in conjunction with increased plasma MPA concentrations, but not in the wild-type or the Mrp2-/- mice. This study demonstrated that: a) MPA appears to be a substrate for P-gp, and b) MPA plasma concentrations are influenced by multiple membrane transporters. Drug-transporter interactions must be considered in patients receiving mycophenolic acid products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transplant Immunology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - IMMUNOSUPPRESSIVE agents
KW - TRANSPLANTATION immunology
KW - TRANSPLANTATION of organs, tissues, etc.
KW - MICE as laboratory animals
KW - Cyclosporine
KW - Knockout mouse
KW - mdr1
KW - Mrp2
KW - Mycophenotic acid
KW - P-glycoprotein
N1 - Accession Number: 34256389; Jian Wang 1 Figurski, Michael 2 Shaw, Leslie M. 3 Burckart, Gilbert J. 3; Email Address: gilbert.burckart@fda.hhs.gov; Affiliation: 1: Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089, United States 2: Xenobiotics Toxicokinetics Research Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 3: United States Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, United States; Source Info: Jul2008, Vol. 19 Issue 3/4, p192; Subject Term: GLYCOPROTEINS; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: TRANSPLANTATION immunology; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Cyclosporine; Author-Supplied Keyword: Knockout mouse; Author-Supplied Keyword: mdr1; Author-Supplied Keyword: Mrp2; Author-Supplied Keyword: Mycophenotic acid; Author-Supplied Keyword: P-glycoprotein; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.trim.2008.05.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34256389&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lefrère, J. -J.
AU - Laperche, S.
AU - Roudot-Thoraval, F.
T1 - Hepatitis G virus: a suitable marker of in vivo efficacy for pathogen inactivation.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2008/07//
VL - 95
IS - 1
M3 - Article
SP - 76
EP - 78
PB - Wiley-Blackwell
SN - 00429007
AB - Being an orphan virus despite a large number of investigations, hepatitis G virus is a blood-borne agent for which screening is not required in blood donations. The in vivo efficacy of pathogen inactivation methods could be assessed by the absence of hepatitis G virus markers after transfusion of pathogen-inactivated blood products, in recipients susceptible to infection before the transfusion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS viruses
KW - VIRUS inactivation
KW - BLOODBORNE infections
KW - BLOOD products
KW - BLOOD transfusion
KW - SAFETY measures
KW - hepatitis G virus
KW - pathogen inactivation
KW - transfusion safety
N1 - Accession Number: 34184697; Lefrère, J. -J. 1; Email Address: jeanjacqueslefrere@orange.fr Laperche, S. 1 Roudot-Thoraval, F. 2; Affiliation: 1: Department of Blood-Transmissible Agents, National Institute of Blood Transfusion, Paris, France 2: Public Health Service, Henri-Mondor Hospital, and French Independent Review Board, Ethical Committee of Ile-de-France IX, Créteil, France; Source Info: Jul2008, Vol. 95 Issue 1, p76; Subject Term: HEPATITIS viruses; Subject Term: VIRUS inactivation; Subject Term: BLOODBORNE infections; Subject Term: BLOOD products; Subject Term: BLOOD transfusion; Subject Term: SAFETY measures; Author-Supplied Keyword: hepatitis G virus; Author-Supplied Keyword: pathogen inactivation; Author-Supplied Keyword: transfusion safety; Number of Pages: 3p; Document Type: Article
L3 - 10.1111/j.1423-0410.2008.01050.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34184697&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Doney, Brent
AU - Greskevitch, Mark
AU - Ki Moon Bang
AU - Groce, Dennis
AU - Syamlal, Girija
T1 - Respirator Use and Practices.
JO - Water Environment & Technology
JF - Water Environment & Technology
Y1 - 2008/07//
VL - 20
IS - 7
M3 - Article
SP - 54
EP - 55
SN - 10449493
AB - The article discusses the contents of a report published by the U.S. Institute for Occupational Safety and Health (NIOSH) and the U.S. Department of Labor's Bureau of Labor Statistics titled "Respirator Usage in Private Sector Firms, 2001" based on the "Survey of Respirator Use and Practices." Results state that approximately 22.4 percent of the establishments in this classification used respirators for required purposes in 2001. Among the types of respirators used, air-supplied respirators were used in 12 percent of electric, gas and sanitary services establishments compared to 0.7 of all private industry establishments.
KW - Industrial safety
KW - Business enterprises
KW - Industrial surveys
KW - Breathing apparatus
KW - United States
KW - United States. Bureau of Labor Statistics
N1 - Accession Number: 33425461; Doney, Brent 1; Greskevitch, Mark 1; Ki Moon Bang 1; Groce, Dennis 2; Syamlal, Girija 1; Affiliations: 1: U.S. National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies; 2: EG&G Technical Services Inc.; Issue Info: Jul2008, Vol. 20 Issue 7, p54; Thesaurus Term: Industrial safety; Thesaurus Term: Business enterprises; Subject Term: Industrial surveys; Subject Term: Breathing apparatus; Subject: United States ; Company/Entity: United States. Bureau of Labor Statistics; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 2p; Illustrations: 2 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33425461&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105662534
T1 - An innovative approach to determine fetal risk: the FDA Office of Women's Health Pregnancy Exposure Registry Web Listing.
AU - Sharma P
AU - Parekh A
AU - Uhl K
Y1 - 2008/07//
N1 - Accession Number: 105662534. Language: English. Entry Date: 20081010. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Women's Health. NLM UID: 9101000.
KW - Fetal Abnormalities -- Chemically Induced
KW - Fetal Abnormalities -- Risk Factors
KW - Registries, Disease
KW - Substance Abuse, Perinatal -- Prevention and Control
KW - Female
KW - Fetus
KW - Pregnancy
SP - 226
EP - 228
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 18
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Food and Drug Administration, Office of Women's Health, Rockville, Maryland.
U2 - PMID: 18468921.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105662534&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhang, L.
AU - Zhang, Y.
AU - Strong, J. M.
AU - Reynolds, K. S.
AU - Huang, S. -M.
T1 - A regulatory viewpoint on transporter-based drug interactions.
JO - Xenobiotica
JF - Xenobiotica
Y1 - 2008/07//Jul/Aug2008
VL - 38
IS - 7/8
M3 - Article
SP - 709
EP - 724
PB - Taylor & Francis Ltd
SN - 00498254
AB - 1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation of a new molecular entity's (NME) drug-drug interaction potential is an integral part of drug development and regulatory review before its market approval. Clinically relevant interactions mediated by transporters are of increasing interest in clinical development and research in this emerging area and it has been revealed that drug transporters can play an important role in modulating drug absorption, distribution, metabolism and elimination. 2. Acting alone or in concert with drug-metabolizing enzymes transporters can affect the pharmacokinetics and/or pharmacodynamics of a drug. The newly released drug interaction guidance by the US Food and Drug Administration (USFDA) includes new information addressing drug transporter interactions with a primary focus on P-glycoprotein (P-gp, ABCB1). 3. This paper provides a regulatory viewpoint on transporters and their potential role in drug-drug interactions. It first outlines information that might be needed during drug development and ultimately included in new drug application (NDA) submissions to address potential transporter-mediated drug interactions. Next, it explains criteria that may warrant conduct of in vivo P-gp-mediated drug interaction studies based on in vitro assessment. In addition, it includes a review case that describes the evaluation of data suggesting a P-gp-based induction interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Xenobiotica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacology
KW - Drug interactions
KW - Pharmacokinetics
KW - Drug development
KW - Glycoproteins
KW - drug development
KW - drug—drug interaction
KW - drug-drug interaction
KW - exposure—response relationship
KW - exposure-response relationship
KW - guidance
KW - labelling
KW - new drug application
KW - regulatory
KW - risk management
KW - tipranavir
KW - Transporter
N1 - Accession Number: 33418863; Zhang, L. 1; Zhang, Y. 1; Strong, J. M. 2; Reynolds, K. S. 1; Huang, S. -M. 1; Email Address: shiewmei.huang@fda.hhs.gov; Affiliations: 1: Offices of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; 2: Offices of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Jul/Aug2008, Vol. 38 Issue 7/8, p709; Thesaurus Term: Pharmacology; Subject Term: Drug interactions; Subject Term: Pharmacokinetics; Subject Term: Drug development; Subject Term: Glycoproteins; Author-Supplied Keyword: drug development; Author-Supplied Keyword: drug—drug interaction; Author-Supplied Keyword: drug-drug interaction; Author-Supplied Keyword: exposure—response relationship; Author-Supplied Keyword: exposure-response relationship; Author-Supplied Keyword: guidance; Author-Supplied Keyword: labelling; Author-Supplied Keyword: new drug application; Author-Supplied Keyword: regulatory; Author-Supplied Keyword: risk management; Author-Supplied Keyword: tipranavir; Author-Supplied Keyword: Transporter; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 16p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/00498250802017715
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33418863&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2008-07753-009
AN - 2008-07753-009
AU - Lehtola, Marika M.
AU - van der Molen, Henk F.
AU - Lappalainen, Jorma
AU - Hoonakker, Peter L. T.
AU - Hsiao, Hongwei
AU - Haslam, Roger A.
AU - Hale, Andrew R.
AU - Verbeek, Jos H.
T1 - The effectiveness of interventions for preventing injuries in the construction industry: A systematic review.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2008/07//
VL - 35
IS - 1
SP - 77
EP - 85
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - Lehtola, Marika M., Finnish Institute of Occupational Health, P.O. Box 93 (Neulanimentie 4), FI-70701, Kuopio, Finland
N1 - Accession Number: 2008-07753-009. PMID: 18482821 Partial author list: First Author & Affiliation: Lehtola, Marika M.; Finnish Institute of Occupational Health, Kuopio, Finland. Release Date: 20090601. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Intervention; Occupational Safety; Prevention; Treatment Effectiveness Evaluation. Minor Descriptor: Business Organizations. Classification: Health & Mental Health Treatment & Prevention (3300); Working Conditions & Industrial Safety (3670). Population: Human (10). Methodology: Empirical Study; Literature Review; Systematic Review. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2008.
AB - Background: Occupational injury rates among construction workers are the highest among the major industries. A number of injury-prevention interventions have been proposed, yet the effectiveness of these is uncertain. Thus a systematic review evaluating the effectiveness of interventions for preventing occupational injuries among construction workers was conducted. Methods: Seven databases were searched, from the earliest available dates through June 2006, for published findings of injury prevention in construction studies. Acceptable study designs included RCTs; controlled before-after studies; and interrupted time series (ITS). Effect sizes of similar interventions were pooled into a meta-analysis in January 2007. Results: Of 7522 titles found, four ITS studies and one controlled ITS study met the inclusion criteria. The overall methodologic quality was low. No indications of publication bias were found. Findings from a safety-campaign study and a drug-free-workplace study indicated that both interventions significantly reduced the level and the trend of injuries. Three studies that evaluated legislation did not decrease the level (ES 0.69; 95% CI = -1.70, 3.09) and made the downward trend (ES 0.28; 95% CI = 0.05, 0.51) of injuries less favorable. Conclusions: Limited evidence was found for the effectiveness of a multifaceted safety campaign and a multifaceted drug program, but no evidence was found that legislation is effective to prevent nonfatal or fatal injuries in the construction industry. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment effectiveness
KW - intervention
KW - prevention
KW - occupational injuries
KW - construction industry
KW - safety
KW - 2008
KW - Injuries
KW - Intervention
KW - Occupational Safety
KW - Prevention
KW - Treatment Effectiveness Evaluation
KW - Business Organizations
KW - 2008
U1 - Sponsor: Office of the Australian Federal Safety Commissioner, Australia. Recipients: No recipient indicated
DO - 10.1016/j.amepre.2008.03.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07753-009&site=ehost-live&scope=site
UR - ORCID: 0000-0002-6537-6100
UR - ORCID: 0000-0001-7842-9171
UR -
UR - marika.lehtola@ttl.fi
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14599-002
AN - 2008-14599-002
AU - Rhoades, Everett R.
AU - Carey, J. Chris
AU - Jacobs, Bette Kiltner
AU - Brenneman, George
T1 - The health of American Indian and Alaska native women, infants and children.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2008/07//
VL - 12
IS - Suppl1
SP - S2
EP - S3
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Rhoades, Everett R., Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK, US
N1 - Accession Number: 2008-14599-002. Partial author list: First Author & Affiliation: Rhoades, Everett R.; Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK, US. Release Date: 20081215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Public Health; Racial and Ethnic Groups. Minor Descriptor: Family. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jul, 2008.
AB - American Indians and Alaska Natives (AI/AN) bear a disproportionate burden of illness and health risks, compared to other races and ethnic groups in the U.S. In this special supplement to the Maternal and Child Health Journal, we selected reports of research that identify steps for improving the health of AI/AN mothers and offspring. We received a number of research reports that included analyses of existing and newly collected data involving a range of AI/AN maternal and child health (MCH) topics. The papers in this category illustrate the importance of a strong and culturally-relevant public health infrastructure. The reports presented here add to the present fund of knowledge relating to unacceptable health disparities and excess health risks among AI/AN and provide examples of measures to improve health equality among AI/AN families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health
KW - American Indian
KW - Alaska native women
KW - infants
KW - children
KW - public health
KW - health risks
KW - health equality
KW - American Indians
KW - ethnic groups
KW - 2008
KW - Alaska Natives
KW - American Indians
KW - Public Health
KW - Racial and Ethnic Groups
KW - Family
KW - 2008
DO - 10.1007/s10995-008-0395-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14599-002&site=ehost-live&scope=site
UR - everettrhoades@msn.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01660-019
AN - 2009-01660-019
AU - Jing, Yi
AU - Dowdy, Janet A.
AU - Van Scott, Michael R.
AU - Fedan, Jeffrey S.
T1 - Hyperosmolarity-induced dilation and epithelial bioelectric responses of guinea pig trachea in vitro: Role of kinase signaling.
JF - The Journal of Pharmacology and Experimental Therapeutics
JO - The Journal of Pharmacology and Experimental Therapeutics
JA - J Pharmacol Exp Ther
Y1 - 2008/07//
VL - 326
IS - 1
SP - 186
EP - 195
CY - US
PB - American Society for Pharmacology & Experimental Therapeutics ASPET
SN - 0022-3565
SN - 1521-0103
AD - Fedan, Jeffrey S., Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2009-01660-019. PMID: 18413857 Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Jing, Yi; Department of Biochemistry and Molecular Pharmacology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, US. Release Date: 20090810. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Jing, Yi. Major Descriptor: Biochemistry; Epithelial Cells; Kinases; Trachea; Cell Signaling. Minor Descriptor: Guinea Pigs. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2008.
AB - Exercise-induced airway obstruction is thought to involve evaporative water loss and hyperosmolarity of the airway surface liquid. Hyperosmolar challenge of the epithelium of isolated, perfused guinea pig trachea rapidly alters transepithelial potential difference (Vt), and it elicits smooth muscle relaxation mediated by epithelium-derived relaxing factor (EpDRF). In many cell types, protein kinases mediate responses to hyperosmolarity and regulatory volume increase. In this study, inhibitors were used to investigate the involvement of kinases and phosphatases in bioelectric responses of epithelium to hyperosmolarity and their possible relationship to EpDRF-mediated relaxation. After contraction of the perfused trachea with extraluminal methacholine, D-mannitol applied intraluminally (≤80 mosM) increased Vt and elicited dilation of the smooth muscle with a similar concentration-dependence; higher concentrations decreased Vt. In tracheas exposed to 30 mosM D-mannitol (∼EC₅₀), 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB 203580) and SKF 86002 [6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole] (p38 inhibitors) potentiated the dilation, whereas SP 600125 [anthra[1,9-cd]pyrazol-6(2H)-one-1,9-pyrazoloanthrone] and dicumarol [c-Jun NH₂-terminal kinase (JNK) inhibitors], chelerythrine [nonselective protein kinase C (PKC) inhibitor], and NaAsO₂ (mitogen-activated protein kinase stress inducer) and Na₃VO₄ (protein tyrosine phosphatase inhibitor) inhibited the hyperpolarization. Large increases in the phosphorylation of p38 and JNK occurred at concentrations higher than those needed to elicit functional responses. The phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002) and Na₃VO₄ did not affect the Vt responses, but they inhibited methacholine-induced constriction; SP 600125 and dicumarol potentiated, and chelerythrine inhibited, methacholine-induced epithelial hyperpolarization. These results suggest that JNK, PKC, and phosphatase(s) are involved in hyperosmolarity-induced hyperpolarization of the tracheal epithelium but that p38 is involved in EpDRF-mediated relaxation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epithelial cells
KW - guinea pigs
KW - trachea
KW - kinase signaling
KW - epithelium derived relaxing factor
KW - hyperosmolarity induced dilation
KW - airway constriction
KW - 2008
KW - Biochemistry
KW - Epithelial Cells
KW - Kinases
KW - Trachea
KW - Cell Signaling
KW - Guinea Pigs
KW - 2008
U1 - Sponsor: American Heart Association, Ohio Valley Affiliate, US. Other Details: Predoctoral fellowship. Recipients: Jing, Yi
DO - 10.1124/jpet.107.135871
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01660-019&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1782-1334
UR -
UR - jsf2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08282-047
AN - 2008-08282-047
AU - Lathers, Claire M.
AU - Schraeder, Paul L.
AU - Bungo, Michael W.
T1 - 'Preventive measures for sudden cardiac death in epilepsy beyond therapies': Reply.
JF - Epilepsy & Behavior
JO - Epilepsy & Behavior
JA - Epilepsy Behav
Y1 - 2008/07//
VL - 13
IS - 1
SP - 265
EP - 269
CY - Netherlands
PB - Elsevier Science
SN - 1525-5050
AD - Lathers, Claire M., Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, US, 20855
N1 - Accession Number: 2008-08282-047. Partial author list: First Author & Affiliation: Lathers, Claire M.; Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20080630. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Death and Dying; Epilepsy; Heart Disorders; Risk Factors. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: Jul, 2008.
AB - Reply to comments made by Fulvio A. Scorza, Ricardo M. Arida, and Esper A. Cavalheiro (see record [rid]2008-08282-046[/rid]) on the current authors' original article (see record [rid]2007-19488-002[/rid]) entitled 'The mystery of sudden death: Mechanisms for risks.' Our review addressed the possible overlapping mechanisms that may apply to the risk of sudden unexpected death occurring in epilepsy (SUDEP) and in cardiac disease. It explored the interaction between the central and peripheral autonomic nervous systems and the cardiopulmonary systems, and proposed mechanistic factors in SUDEP, listing risk categories of arrhythmogenic factors, respiratory factors, and hypoxia, and psychological factors and mechanisms for risks associated with each category. Scorza et al. summarized by noting that clarification of risk factors and establishment of the mechanism of SUDEP are important to establish preventative measures for SUDEP and emphasized the need to strive for full seizure control. We compliment Scorza et al. for raising important issues above and beyond standard medical intervention for the prevention/treatment of sudden death in cardiac patients or in patients with epilepsy at risk for sudden death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epilepsy
KW - sudden death
KW - risk factors
KW - cardiac diseases
KW - 2008
KW - Death and Dying
KW - Epilepsy
KW - Heart Disorders
KW - Risk Factors
KW - 2008
DO - 10.1016/j.yebeh.2008.01.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08282-047&site=ehost-live&scope=site
UR - lathers@attglobal.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09036-005
AN - 2008-09036-005
AU - Turk, Dennis C.
AU - Dworkin, Robert H.
AU - Revicki, Dennis
AU - Harding, Gale
AU - Burke, Laurie B.
AU - Cella, David
AU - Cleeland, Charles S.
AU - Cowan, Penney
AU - Farrar, John T.
AU - Hertz, Sharon
AU - Max, Mitchell B.
AU - Rappaport, Bob A.
T1 - Identifying important outcome domains for chronic pain clinical trials: An IMMPACT survey of people with pain.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2008/07//
VL - 137
IS - 2
SP - 276
EP - 285
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Turk, Dennis C., Department of Anesthesiology, University of Washington, Box 356540, Seattle, WA, US, 98195
N1 - Accession Number: 2008-09036-005. PMID: 17937976 Partial author list: First Author & Affiliation: Turk, Dennis C.; University of Washington, Seattle, WA, US. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20090413. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Pain; Clinical Trials. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Brief Pain Inventory; Multidimensional Pain Inventory; SF-12 Health Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2008.
AB - This two-phase study was conducted to identify relevant domains of patient-reported outcomes from the perspective of people who experience chronic pain. In Phase 1, focus groups were conducted to generate a pool of patient outcome-related domains and their components. The results of the focus groups identified 19 aspects of their lives that were significantly impacted by the presence of their symptoms and for which improvements were important criteria they would use in evaluating the effectiveness of any treatment. Phase 2 was conducted to examine the importance and relevance of domains identified from a much larger and diverse sample of people with chronic pain. A survey was developed and posted on the American Chronic Pain Association website. Participants were asked to rate the importance of each item or domain identified by the focus groups on a scale of 0 to 10 (i.e., 0 = 'not at all important' and 10 = 'extremely important'). The survey was completed by 959 individuals. The results indicate that all 19 aspects of daily life derived from the focus groups were considered important with a majority of respondents indicating a score of 8 or greater. In addition to pain reduction, the most important aspects were enjoyment of life, emotional well-being, fatigue, weakness, and sleep-related problems. Chronic pain clearly impacts health-related quality of life. The results of the two phases of the study indicate that people with chronic pain consider functioning and well-being as important areas affected by the presence of symptoms and as appropriate targets of treatment. These multiple outcomes should be considered when evaluating the efficacy and effectiveness of chronic pain treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chronic pain
KW - clinical trials
KW - 2008
KW - Chronic Pain
KW - Clinical Trials
KW - 2008
U1 - Sponsor: Initiative on Methods, Measurement and Pain Assessment in Clinical Trials. Other Details: United BioSource Corporation (formally known as The MEDTAP Institute at UBC). Recipients: No recipient indicated
DO - 10.1016/j.pain.2007.09.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09036-005&site=ehost-live&scope=site
UR - turkdc@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09467-005
AN - 2008-09467-005
AU - Mark, Tami L.
AU - Harwood, Henrick J.
AU - McKusick, David C.
AU - King, Edward C.
AU - Vandivort-Warren, Rita
AU - Buck, Jeffrey A.
T1 - Mental health and substance abuse spending by age, 2003.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2008/07//
VL - 35
IS - 3
SP - 279
EP - 289
CY - Germany
PB - Springer
SN - 1094-3412
AD - Mark, Tami L., Thomson Healthcare, 4301 Connecticut Avenue, NW Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2008-09467-005. PMID: 18512156 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Healthcare, Washington, DC, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20080728. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Age Differences; Drug Abuse; Drug Rehabilitation; Mental Health. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul, 2008.
AB - This article examines 1997 national expenditures on mental health and substance abuse (MH/SA) treatment by 3 major age groups: 0-17, 18-64, and 65 and older. Of the total $82.4 billion in MH/SA expenditures, 13% went to children, 72% to adults, and 15% to older adults. MH/SA treatment expenditures made up 9% of total health care expenditures on children, 11% of total health care expenditures on adults, and 3% of total health care expenditures on older adults. Across the 3 age groups, distinct differences emerged in the distribution of MH/SA expenditures by provider-type. For example, about 85% of spending for youth was for specialty MH/SA providers, compared to 76% for adults and 51% for older adults. In addition, 33% of MH/SA spending for older adults went to nursing home care, while other age groups had almost no expenditures in nursing homes. Age-specific estimates enable policymakers, providers, and researchers to design programs and studies more appropriately tailored to specific age groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - substance abuse
KW - treatment
KW - age differences
KW - 2008
KW - Age Differences
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Mental Health
KW - 2008
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1007/s11414-008-9118-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09467-005&site=ehost-live&scope=site
UR - Tami.Mark@thomson.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09266-004
AN - 2008-09266-004
AU - Raffaele, Kathleen C.
AU - Fisher, J. Edward Jr.
AU - Hancock, Scott
AU - Hazelden, Keith
AU - Sobrian, Sonya K.
T1 - Determining normal variability in a developmental neurotoxicity test: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2008/07//
VL - 30
IS - 4
SP - 288
EP - 325
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Raffaele, Kathleen C.
N1 - Accession Number: 2008-09266-004. PMID: 18280700 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Raffaele, Kathleen C.; Office of Pesticide Programs, U.S. EPA, Washington, DC, US. Release Date: 20090105. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Development; Neurology; Neurotoxicity; Testing. Minor Descriptor: Habituation. Classification: Neuropsychology & Neurology (2520). Population: Human (10); Animal (20). References Available: Y. Page Count: 38. Issue Publication Date: Jul, 2008.
AB - With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental changes in motor activity, auditory startle habituation, and various learning and memory parameters. One issue in interpreting these data is the level of variability for the measures used in these studies: excessive variability can obscure treatment-related effects, or conversely, small but statistically significant changes could be viewed as treatment related, when they might in fact be within the normal range. To aid laboratories in designing useful DNT studies for regulatory consideration, an operational framework for evaluating observed variability in study data has been developed. Elements of the framework suggest how an investigator might approach characterization of variability in the dataset; identification of appropriate datasets for comparison; evaluation of similarities and differences in variability between these datasets, and of possible sources of the variability, including those related to test conduct and test design. A case study using auditory startle habituation data is then presented, employing the elements of this proposed approach. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - normal variability
KW - developmental neurotoxicity test
KW - ILSI Research Foundation/Risk Science Institute
KW - expert working group
KW - neurodevelopmental endpoints
KW - 2008
KW - Development
KW - Neurology
KW - Neurotoxicity
KW - Testing
KW - Habituation
KW - 2008
DO - 10.1016/j.ntt.2007.12.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09266-004&site=ehost-live&scope=site
UR - raffaele.kathleen@epa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15528-001
AN - 2008-15528-001
AU - Booth-Butterfield, Steve
AU - Welbourne, Jennifer L.
AU - Ott, Sybil
AU - Hartley, Tara
AU - Thomas, Kimberly Clough
AU - Lawryk, Nicholas J.
T1 - A communication matrix intervention to increase adoption of federal government safety recommendations.
JF - Health Communication
JO - Health Communication
JA - Health Commun
Y1 - 2008/07//
VL - 23
IS - 4
SP - 307
EP - 312
CY - United Kingdom
PB - Taylor & Francis
SN - 1041-0236
SN - 1532-7027
AD - Welbourne, Jennifer L., Department of Psychology, University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, US, 78541-2999
N1 - Accession Number: 2008-15528-001. PMID: 18701995 Partial author list: First Author & Affiliation: Booth-Butterfield, Steve; Healthy Influence, LLC Morgantown, Morgantown, WV, US. Other Publishers: Lawrence Erlbaum. Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communication; Government; Hygiene; Intervention; Occupational Safety. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jul, 2008.
AB - A 3-year, multichannel intervention project assessed adoption of federal government workplace safety testing methods among 3 randomly drawn samples of industrial hygienists. A communication matrix (McGuire, 1985, 1989) framework focusing on stages of reception, processing, and response was used to create, implement, and evaluate the intervention. Participants were interviewed by phone during 3 waves: baseline, immediately following year 1 of the intervention, and immediately following year 2 of the intervention. Results indicate a gain in reception over the course of the intervention. Increases in attitudes, control beliefs, intentions, and self-reported behavior were found between baseline and the 1st year of the intervention, and were maintained (although not increased) during the 2nd year of the intervention. Strengths and weaknesses of the intervention are viewed through the scope of the communication matrix. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - communication matrix intervention
KW - federal government safety recommendations
KW - industrial hygienists
KW - 2008
KW - Communication
KW - Government
KW - Hygiene
KW - Intervention
KW - Occupational Safety
KW - 2008
DO - 10.1080/10410230802229696
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15528-001&site=ehost-live&scope=site
UR - welbournjl@utpa.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18567-006
AN - 2008-18567-006
AU - Wu, Ping
AU - Hoven, Christina W.
AU - Liu, Xinhua
AU - Fuller, Cordelia J.
AU - Fan, Bin
AU - Musa, George
AU - Wicks, Judith
AU - Mandell, Donald
AU - Cook, Judith A.
T1 - The relationship between depressive symptom levels and subsequent increases in substance use among youth with severe emotional disturbance.
JF - Journal of Studies on Alcohol and Drugs
JO - Journal of Studies on Alcohol and Drugs
JA - J Stud Alcohol Drugs
Y1 - 2008/07//
VL - 69
IS - 4
SP - 520
EP - 527
CY - US
PB - Alcohol Research Documentation
SN - 1937-1888
SN - 1938-4114
AD - Wu, Ping, Departments of Psychiatry and Epidemiology, Columbia University, 1051 Riverside Drive, Unit, New York, NY, US, 10032
N1 - Accession Number: 2008-18567-006. PMID: 18612567 Other Journal Title: Journal of Studies on Alcohol; Quarterly Journal of Studies on Alcohol. Partial author list: First Author & Affiliation: Wu, Ping; Departments of Psychiatry and Epidemiology, Columbia University, New York, NY, US. Release Date: 20090309. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Wu, Ping. Major Descriptor: Drug Abuse; Emotional Disturbances; Major Depression; Symptoms. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Followup Study; Longitudinal Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2008.
AB - Objective: This study examined the relationship between levels of depressive symptoms and subsequent increases in substance use among 784 youth with severe emotional disturbance enrolled in Medicaid-funded behavioral health care plans. Method: Youth at five sites nationwide were interviewed about their emotional and behavior problems, as well as their use of cigarettes, alcohol, and drugs—at both baseline and follow-up. Results: (1) Levels of depressive symptoms were significantly associated with concurrent substance use at baseline. (2) Baseline levels of depressive symptoms predicted subsequent changes in substance use, especially use of illicit drugs and multiple drugs. (3) These findings remained significant, even after controlling for sociodemographic, family, and individual characteristics. Conclusions: These results indicate that depressive symptoms early in life may signal a risk for increasing involvement in substance use among severe emotional disturbed youth. This finding has important clinical implications for the prevention of substance misuse in this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depressive symptoms
KW - substance use
KW - youths
KW - severe emotional disturbances
KW - 2008
KW - Drug Abuse
KW - Emotional Disturbances
KW - Major Depression
KW - Symptoms
KW - 2008
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: DA013473. Recipients: Wu, Ping
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: Cooperative agreement UR7T11I267. Recipients: No recipient indicated
DO - 10.15288/jsad.2008.69.520
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18567-006&site=ehost-live&scope=site
UR - wup@childpsych.columbia.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18369-005
AN - 2008-18369-005
AU - Zandi, Peter P.
AU - Belmonte, Pamela L.
AU - Willour, Virginia L.
AU - Goes, Fernando S.
AU - Badner, Judith A.
AU - Simpson, Sylvia G.
AU - Gershon, Elliot S.
AU - McMahon, Francis J.
AU - DePaulo, J. Raymond Jr.
AU - Potash, James B.
T1 - Association study of Wnt signaling pathway genes in bipolar disorder.
JF - Archives of General Psychiatry
JO - Archives of General Psychiatry
JA - Arch Gen Psychiatry
Y1 - 2008/07//
VL - 65
IS - 7
SP - 785
EP - 793
CY - US
PB - American Medical Association
SN - 0003-990X
SN - 1538-3636
AD - Zandi, Peter P., Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD, US, 21205
N1 - Accession Number: 2008-18369-005. PMID: 18606951 Other Journal Title: A.M.A. Archives of General Psychiatry; JAMA Psychiatry. Partial author list: First Author & Affiliation: Zandi, Peter P.; Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, MD, US. Institutional Authors: Bipolar Disorder Phenome Group, National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Release Date: 20090223. Correction Date: 20160714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Potash, James B. Major Descriptor: Bipolar Disorder; Family; Genes; Nucleotides; Susceptibility (Disorders). Minor Descriptor: Polymorphism. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Diagnostic Interview for Genetic Studies; Schedule for Affective Disorders and Schizophrenia, Lifetime Version; Global Assessment Scale DOI: 10.1037/t48384-000. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Web Sites Internet. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2008.
AB - Context: The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder. Objective: To test for an association between candidate genes in the Wnt signaling pathways and disease susceptibility in a family-based bipolar disorder study. Design: Two hundred twenty-seven tagging single nucleotide polymorphisms (SNPs) from 34 genes were successfully genotyped. Initial results led us to focus on the gene PPARD, in which we genotyped an additional 13 SNPs for follow-up. Setting: Nine academic medical centers in the United States. Participants: Five hundred fifty-four offspring with bipolar disorder and their parents from 317 families. Main Outcome Measures: Family-based association using FBAT and HBAT (http://www.biostat.harvard.edu/∼fbat/default.html; Harvard School of Public Health, Boston, Massachusetts). Exploratory analyses testing for interactions of PPARD SNPs with clinical covariates and with other Wnt genes were conducted with GENASSOC (Stata Corp, College Station, Texas). Results: In the initial analysis, the most significantly associated SNP was rs2267665 in PPARD (nominal P < .001). This remained significant at P = .05 by permutation after accounting for all SNPs tested. Additional genotyping in PPARD yielded 4 SNPs in 1 haplotype block that were significantly associated with bipolar disorder (P < .01), the most significant being rs9462082 (P < .001). Exploratory analyses revealed significant evidence (P < .01) for interactions of rs9462082 with poor functioning on the Global Assessment Scale (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.85-6.08) and with SNPs in WNT2B (rs3790606: OR, 2.56; 95% CI, 1.67-4.00) and WNT7A (rs4685048: OR, 1.79; 95% CI, 1.23-2.63). Conclusions: We found evidence for association of bipolar disorder with PPARD, a gene in the Wnt signaling pathway. The consistency of this result with one from the Wellcome Trust Case-Control Consortium encourages further study. If the finding can be confirmed in additional samples, it may illuminate a new avenue for understanding the pathogenesis of severe bipolar disorder and developing more effective treatments. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Wnt signaling pathway genes
KW - bipolar disorder
KW - disease susceptibility
KW - family
KW - single nucleotide polymorphisms
KW - 2008
KW - Bipolar Disorder
KW - Family
KW - Genes
KW - Nucleotides
KW - Susceptibility (Disorders)
KW - Polymorphism
KW - 2008
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH-042243. Recipients: Potash, James B.
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH-061613. Recipients: Gershon, Elliot S.
U1 - Sponsor: National Institute of Mental Health. Grant: K01 MH-072866. Recipients: Zandi, Peter P.
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Stanley Medical Research Institute. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: McMahon, Francis J.
U1 - Sponsor: Alex Brown Foundation. Recipients: Belmonte, Pamela L.
U1 - Sponsor: Margaret Price Investigatorships. Recipients: Willour, Virginia L.; Potash, James B.
DO - 10.1001/archpsyc.65.7.785
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18369-005&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - pzandi@jhsph.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17462-014
AN - 2008-17462-014
AU - Alakeson, Vidhya
T1 - Self-directed care for adults with serious mental illness: The barriers to progress.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/07//
VL - 59
IS - 7
SP - 792
EP - 794
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Alakeson, Vidhya, Office of the Assistant Secretary, Department of Health and Human Services, Humphrey Bldg., 200 Independence Ave., Washington, DC, US, 20201
N1 - Accession Number: 2008-17462-014. PMID: 18586997 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Alakeson, Vidhya; Office of the Assistant Secretary, Department of Health and Human Services, Washington, DC, US. Release Date: 20090427. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Innovation; Mental Disorders; Mental Health Services; Self-Evaluation. Minor Descriptor: Mental Health; Uncertainty. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 3. Issue Publication Date: Jul, 2008.
AB - The President’s New Freedom Commission on Mental Health identified self-directed care as one service innovation that could create a more consumer- and family oriented mental health system. Four years later, there are still fewer than 400 consumers in five states accessing self-directed care in the public mental health system. This Open Forum identifies three main barriers to explain this lack of progress: the absence of a strong evidence base to support the effectiveness of self-directed care for serious mental illness, uncertainty over the appropriate scope of self-directed care, and the absence of a sustainable source of funding. The introduction of the 1915(i) provision of the Social Security Act in 2007 appears to partly address the funding barrier to self-directed care. There is also a strong case for a large-scale evaluation of self-directed care for persons with serious mental illness to address the two remaining barriers to progress. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self-directed care
KW - adults
KW - serious mental illness
KW - barriers
KW - service innovation
KW - mental health system
KW - 2008
KW - Innovation
KW - Mental Disorders
KW - Mental Health Services
KW - Self-Evaluation
KW - Mental Health
KW - Uncertainty
KW - 2008
U1 - Sponsor: Commonwealth Fund, US. Date: from 2006 to 2007. Other Details: Harkness Fellowship in Healthcare Policy. Recipients: No recipient indicated
DO - 10.1176/appi.ps.59.7.792
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17462-014&site=ehost-live&scope=site
UR - vidhya.alakeson@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08996-008
AN - 2008-08996-008
AU - Pfefferle, Susan G.
AU - Weinberg, Dana Beth
T1 - Certified nurse assistants making meaning of direct care.
JF - Qualitative Health Research
JO - Qualitative Health Research
JA - Qual Health Res
Y1 - 2008/07//
VL - 18
IS - 7
SP - 952
EP - 961
CY - US
PB - Sage Publications
SN - 1049-7323
SN - 1552-7557
N1 - Accession Number: 2008-08996-008. Partial author list: First Author & Affiliation: Pfefferle, Susan G.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20090427. Correction Date: 20111114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Nurses; Nursing; Nursing Homes; Professional Certification; Stigma. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2008.
AB - Using qualitative data from 87 focus groups with certified nurse assistants (CNAs) in 16 nursing homes in Massachusetts, we explore ways that CNAs make meaning of their work despite devaluations, such as lack of respect from management and residents, and the physical and emotional demands of such low-status work. CNAs’ meaning making represents an effort to assert a positive identity rather than accept the stigmatization associated with their work. Assertions of the value help CNAs reconstitute their identities. Assertions of meaning, which depend upon providing good care to residents regardless of financial reward or management respect and support, make CNAs vulnerable to exploitation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - certified nurse assistants
KW - direct care meaning
KW - nursing homes
KW - stigma
KW - 2008
KW - Nurses
KW - Nursing
KW - Nursing Homes
KW - Professional Certification
KW - Stigma
KW - 2008
U1 - Sponsor: Robert Wood Johnson Foundation/Atlantic Philanthropies, Better Jobs Better Care. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: 5P30 MH068579. Recipients: No recipient indicated
DO - 10.1177/1049732308318031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08996-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08175-005
AN - 2008-08175-005
AU - Malik, Neena M.
AU - Silverman, Jerry
AU - Wang, Kathleen
AU - Janczewski, Colleen
T1 - Domestic violence and dependency courts: The Greenbook demonstration experience.
JF - Journal of Interpersonal Violence
JO - Journal of Interpersonal Violence
JA - J Interpers Violence
Y1 - 2008/07//
VL - 23
IS - 7
SP - 956
EP - 980
CY - US
PB - Sage Publications
SN - 0886-2605
SN - 1552-6518
AD - Malik, Neena M., University of Miami School of Medicine, Department of Pediatrics, P.O. Box 016820 (D-820), Miami, FL, US, 33101
N1 - Accession Number: 2008-08175-005. PMID: 18349343 Partial author list: First Author & Affiliation: Malik, Neena M.; Department of Pediatrics, Division of Clinical Psychology, University of Miami School of Medicine, Miami, FL, US. Release Date: 20081215. Correction Date: 20150216. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adjudication; Child Abuse; Collaboration; Domestic Violence; Social Services. Minor Descriptor: Victimization. Classification: Community & Social Services (3373); Criminal Law & Adjudication (4230). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Direct-Service Worker Survey; Stakeholder Survey DOI: 10.1037/t36921-000. Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 25. Issue Publication Date: Jul, 2008.
AB - This field study reports on a cross-site evaluation of dependency courts in communities receiving federal funding to implement the Greenbook initiative, a multisite demonstration for community improvement of coordinated responses to families victimized by domestic violence and child maltreatment. This article focuses on the dependency court, where child maltreatment cases are heard, specifically court participation in collaborative activities and court practice improvements. Findings indicate that perceptions of judicial leadership varied considerably by site. Cross-training appeared to increase over time, particularly with court staff. Collaborative efforts emerged across the Greenbook initiative with regard to the courts, and some innovative practices appeared within Greenbook sites, such as separate case plans for perpetrators and victims of violence in families, reducing the likelihood of controversial failure to protect charges. Results also highlight challenges inherent in changing court practices. Research and practice implications are discussed, focusing on relevance to other communities attempting to work collaboratively with the court system. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - domestic violence
KW - federal funding
KW - child maltreatment
KW - collaboration
KW - dependency court
KW - 2008
KW - Adjudication
KW - Child Abuse
KW - Collaboration
KW - Domestic Violence
KW - Social Services
KW - Victimization
KW - 2008
U1 - Sponsor: National Institute of Justice. Grant: 2000-MUMU-0014. Other Details: ICF International. Recipients: No recipient indicated
DO - 10.1177/0886260508315122
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08175-005&site=ehost-live&scope=site
UR - Jerry.Silverman@HHS.GOV
UR - nmalik@med.miami.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14599-008
AN - 2008-14599-008
AU - Kvigne, Valborg L.
AU - Leonardson, Gary R.
AU - Borzelleca, Joseph
AU - Brock, Ellen
AU - Neff-Smith, Martha
AU - Welty, Thomas K.
T1 - Alcohol use, injuries, and prenatal visits during three successive pregnancies among American Indian women on the Northern Plains who have children with fetal alcohol syndrome or incomplete fetal alcohol syndrome.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2008/07//
VL - 12
IS - Suppl1
SP - S37
EP - S45
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Kvigne, Valborg L., Aberdeen Area Indian Health Service, 2013 W 15th St #1, Sioux Falls, SD, US, 57104
N1 - Accession Number: 2008-14599-008. Partial author list: First Author & Affiliation: Kvigne, Valborg L.; Aberdeen Area Indian Health Service, Sioux Falls, SD, US. Release Date: 20081215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Fetal Alcohol Syndrome; Injuries; Pregnancy; Prenatal Care. Minor Descriptor: Alcohol Drinking Patterns; Birth; Mothers; Treatment. Classification: Psychological & Physical Disorders (3200); Medical Treatment of Physical Illness (3363). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2008.
AB - Introduction: The purpose of the study was to compare three sequential pregnancies of American Indian women who have children with FAS or children with incomplete FAS with women who did not have children with FAS. Methods: Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome (FAS) (Study 1) or incomplete FAS (Study 2) in 1981-1993. Three successive pregnancies ending in live births of 43 case mothers who had children with FAS, and 35 case mothers who had children with incomplete FAS were compared to the pregnancies of 86 and 70 control mothers who did not have children with FAS, respectively, in the two studies. Prenatal records were abstracted for the index child (child with FAS or incomplete FAS) and siblings born just before and just after the index child, and comparable prenatal records for the controls. Results: Compared to the controls, significantly more case mothers used alcohol before and after all three pregnancies and during pregnancy with the before sibling and the index child. Mothers who had children with FAS reduced their alcohol use during the pregnancy following the birth of the index child. All Study 1 case mothers (100%) and 60% of Study 2 case mothers used alcohol during the pregnancy with the index child compared to 20 and 9% of respective control mothers. More study 1 case mothers experienced unintentional injuries (OR 9.50) and intentional injuries during the index pregnancy (OR 9.33) than the control mothers. Most case mothers began prenatal care in the second trimester. Conclusions: Alcohol use was documented before, during and after each of the three pregnancies. Women of child-bearing age should be screened for alcohol use whenever they present for medical services. Mothers who had a child with FAS decreased their alcohol consumption with the next pregnancy, a finding that supports the importance of prenatal screening throughout pregnancy. Women who receive medical care for injuries should be screened for alcohol use and referred for appropriate treatment. Protective custody, case management and treatment services need to be readily available for women who use alcohol. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol use
KW - injuries
KW - prenatal visits
KW - pregnancies
KW - American Indian women
KW - northern plains
KW - fetal alcohol syndrome
KW - treatment services
KW - injuries during pregnancy
KW - 2008
KW - American Indians
KW - Fetal Alcohol Syndrome
KW - Injuries
KW - Pregnancy
KW - Prenatal Care
KW - Alcohol Drinking Patterns
KW - Birth
KW - Mothers
KW - Treatment
KW - 2008
U1 - Sponsor: Indian Health Service. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
DO - 10.1007/s10995-008-0367-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14599-008&site=ehost-live&scope=site
UR - twelty@earthlink.net
UR - globaldoc@hotmail.com
UR - ebrock@mcvh-vcu.edu
UR - jborzelleca@mcvh-vcu.edu
UR - mpr@zipmt.com
UR - kvig6@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14599-010
AN - 2008-14599-010
AU - Letourneau, Robert J.
AU - Crump, Carolyn E.
AU - Bowling, J. Michael
AU - Kuklinski, Diana M.
AU - Allen, Christopher W.
T1 - Ride Safe: A child passenger safety program for American Indian/Alaska native children.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2008/07//
VL - 12
IS - Suppl1
SP - S55
EP - S63
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Letourneau, Robert J., Department of Health Behavior & Health Education, University of North Carolina at Chapel Hill, School of Public Health, 137 E. Franklin Street, Suite 21, Campus Box 7506, Chapel Hill, NC, US, 27599-7506
N1 - Accession Number: 2008-14599-010. Partial author list: First Author & Affiliation: Letourneau, Robert J.; Department of Health Behavior & Health Education, University of North Carolina at Chapel Hill, School of Public Health, Chapel Hill, NC, US. Release Date: 20081215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alaska Natives; American Indians; Driving Behavior; Motor Traffic Accidents; Safety Devices. Minor Descriptor: Motor Vehicles; Safety Belts. Classification: Promotion & Maintenance of Health & Wellness (3365); Transportation (4090). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2008.
AB - Background: In American Indian/Alaska Native (AI/AN) communities, child safety seat (CSS) use rates are much lower than in non-native communities. To reduce this disparity, Indian Health Service (IHS) staff developed, pilot-tested, and implemented Ride Safe, which provided education, training, and child safety seats for children aged 3-5 participating in Tribal Head Start Centers. Methods: Focus groups, key informant interviews, and technical review guided program development and implementation. Progress reports and child safety seat use observations, conducted at the beginning and end of three program years (Fall 2003 to Spring 2006), assessed program reach and impact. To examine CSS use, we used three multiple logistic regressions, including a conservative intent to treat analysis. Results: Ride Safe reached approximately 3,500 children and their families at 14 sites in six states, providing over 1,700 parents/family members with educational activities, 2,916 child safety seats, and child passenger safety (CPS) technician certification training for 78 Tribal staff. Children were 2.5 times (OR = 2.55, p < .01) as likely to be observed in child safety seats comparing Rounds 1 and 2 data, with the most conservative model showing that the odds of being observed restrained were 74% higher (OR = 1.74, p =< .01) after implementation of the program. Conclusions: The Ride Safe Program effectively increased child safety seat use in AI/ AN communities, however, observed use rates ranging from 30% to 71% remain well below the 2006 all US rate of 93%. Results from CSS educational and distribution/installation programs such as Ride Safe should be considered in light of the need to increase distribution programs and enhance enforcement activities in AI/AN communities, thereby reducing the disparity in AI/AN motor vehicle injuries and death. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ride safe
KW - child passenger safety program
KW - American Indian
KW - Alaska native children
KW - motor vehicle injuries
KW - child safety seat
KW - 2008
KW - Alaska Natives
KW - American Indians
KW - Driving Behavior
KW - Motor Traffic Accidents
KW - Safety Devices
KW - Motor Vehicles
KW - Safety Belts
KW - 2008
U1 - Sponsor: Indian Health Service, Injury Prevention Program, Head Start Program. Recipients: No recipient indicated
U1 - Sponsor: National Highway Traffic Safety Administration (NHTSA), Minnesota Emergency Medical Services Center (MNEMSC), US. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
DO - 10.1007/s10995-008-0332-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14599-010&site=ehost-live&scope=site
UR - Chris.Allen@ihs.gov
UR - diana.kuklinski@ihs.gov
UR - jbowling@email.unc.edu
UR - Carolyn_Crump@unc.edu
UR - Robert_Letourneau@unc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08734-025
AN - 2008-08734-025
AU - Ognibene, Elisa
AU - Adriani, Walter
AU - Caprioli, Antonio
AU - Ghirardi, Orlando
AU - Ali, Syed F.
AU - Aloe, Luigi
AU - Laviola, Giovanni
T1 - The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice.
JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry
JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry
Y1 - 2008/07//
VL - 32
IS - 5
SP - 1269
EP - 1276
CY - Netherlands
PB - Elsevier Science
SN - 0278-5846
SN - 1878-4216
AD - Laviola, Giovanni, Section of Behavioral Neuroscience, Dept. Cell Biology and Neuroscience, Istituto Superiore di Sanita, V.le R. Elena 299, I-00161, Roma, Italy
N1 - Accession Number: 2008-08734-025. PMID: 18501492 Other Journal Title: Progress in Neuro-Psychopharmacology. Partial author list: First Author & Affiliation: Ognibene, Elisa; Section of Behavioral Neuroscience, Dept. Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy. Release Date: 20080714. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Laviola, Giovanni. Major Descriptor: Early Experience; Mice; Neural Development; Neural Plasticity. Minor Descriptor: Animal Models; Brain; Drug Therapy; Genotypes; Mental Disorders; Neuroleptic Drugs; Neuropsychiatry; Separation Reactions; Susceptibility (Disorders). Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30); Female (40). Tests & Measures: Social Preference Test. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jul, 2008.
AB - Objective and Methods: The reeler heterozygous (HZ) mice have provided a model for studying the relationship between reelin (a protein of extracellular matrix) haploinsufficiency and the emergence of neuropsychiatric diseases. In a neurodevelopmental framework, the enduring consequences of early maternal separation (5 h/day during the first postnatal week, or handling controls, H) were studied in reeler HZ and wild type (WT) mice at adulthood. The modulatory effects of a chronic treatment with the atypical antipsychotic olanzapine (OLZ, 1.5 mg/kg for 40 days) were also investigated. Results: Early maternal separation had long-term effects on brain plasticity, with a reduction of brain- and glial- derived neurotrophic factor (BDNF and GDNF) in several brain areas of mice, but such a consequence was less marked in the HZ genotype. On the other hand, treatment with OLZ did not affect at all the GDNF but led to an increase of BDNF levels in maternally separated (SEP) mice, an effect which was far more marked in the HZ genotype. Brain levels of serotonin (5-HT) were markedly increased, striatal dopamine (DA) was increased, whereas metabolites and turnover were decreased, in SEP mice of both genotypes. The spontaneous home-cage activity was generally lower in HZ than WT mice, and OLZ treatment contrasted this hypoactivity profile. Maternal separation also decreased the interest toward an unknown mouse proposed as a social stimulus, but only in WT mice. Conclusion: We investigated the interplay between genetic vulnerability (reelin haploinsufficiency), the outcome of early stressful experiences, and the efficacy of the antipsychotic drug therapy. The reeler HZ genotype exhibited a slightly lower sensitivity to the environmental insult as well as an enhanced response to the atypical antipsychotic treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - early maternal separation
KW - brain derived neurotrophic factor
KW - monoamine levels
KW - adult heterozygous reeler mice
KW - neuropsychiatric diseases
KW - antipsychiatric drug therapy
KW - 2008
KW - Early Experience
KW - Mice
KW - Neural Development
KW - Neural Plasticity
KW - Animal Models
KW - Brain
KW - Drug Therapy
KW - Genotypes
KW - Mental Disorders
KW - Neuroleptic Drugs
KW - Neuropsychiatry
KW - Separation Reactions
KW - Susceptibility (Disorders)
KW - 2008
U1 - Sponsor: National Institutes of Health, ISS, US. Other Details: Implication of auto-antibodies to neuro-receptor fragments in etiology of compulsive behavior and drug addiction. Recipients: No recipient indicated
U1 - Sponsor: Italy-USA Collaborative Program. Other Details: X-linked or Autosomal Mental Retardation Syndromes. Recipients: Laviola, Giovanni
DO - 10.1016/j.pnpbp.2008.03.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08734-025&site=ehost-live&scope=site
UR - laviola@iss.it
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09269-021
AN - 2008-09269-021
AU - Lyons, Ronan A.
AU - Ward, Heather
AU - Brunt, Huw
AU - Macey, Steven
AU - Thoreau, Roselle
AU - Bodger, O. G.
AU - Woodford, Maralyn
T1 - Using multiple datasets to understand trends in serious road traffic casualties.
JF - Accident Analysis and Prevention
JO - Accident Analysis and Prevention
JA - Accid Anal Prev
Y1 - 2008/07//
VL - 40
IS - 4
SP - 1406
EP - 1410
CY - Netherlands
PB - Elsevier Science
SN - 0001-4575
AD - Lyons, Ronan A., Centre for Health Information, Research and Evaluation (CHIRAL), School of Medicine, Swansea University, Singleton Park, Swansea, United Kingdom, SA2 8PP
N1 - Accession Number: 2008-09269-021. PMID: 18606273 Partial author list: First Author & Affiliation: Lyons, Ronan A.; Centre for Health Information, Research and Evaluation (CHIRAL), School of Medicine, Swansea University, Swansea, United Kingdom. Release Date: 20080825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Motor Traffic Accidents; Strategies; Trends. Classification: Transportation (4090). Population: Human (10); Inpatient (50). Location: United Kingdom. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jul, 2008.
AB - Accurate information on the incidence of serious road traffic casualties is needed to plan and evaluate prevention strategies. Traditionally police reported collisions are the only data used. This study investigate the extent to which understanding of trends in serious road traffic injuries is aided by the use of multiple datasets. Health and police datasets covering all or part of Great Britain from 1996-2003 were analysed. There was a significantly decreasing trend in police reported serious casualties but not in the other datasets. Multiple data sources provide a more complete picture of road traffic casualty trends than any single dataset. Increasing availability of electronic health data with developments in anonymised data linkage should provide a better platform for monitoring trends in serious road traffic casualties. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - serious road traffic casualties
KW - trends
KW - prevention strategies
KW - multiple datasets
KW - 2008
KW - Accident Prevention
KW - Motor Traffic Accidents
KW - Strategies
KW - Trends
KW - 2008
DO - 10.1016/j.aap.2008.03.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09269-021&site=ehost-live&scope=site
UR - ORCID: 0000-0002-3976-672X
UR -
UR - ORCID: 0000-0001-5225-000X
UR - maralyn.woodford@tarn.ac.uk
UR - ucesrth@ucl.ac.uk
UR - s.m.macey@swansea.ac.uk
UR - huw.brunt@nphs.wales.nhs.uk
UR - h.ward@ucl.ac.uk
UR - r.a.lyons@swansea.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105707265
T1 - Is special FDA regulation of nanomedicine needed? A conversation with Norris E. Alderson: at this point, the FDA evaluates nanoparticles as it does all other areas under its purview: for safety and efficacy in patients.
AU - Culliton BJ
Y1 - 2008/07/02/Jul/Aug2008 Web Exclusives
N1 - Accession Number: 105707265. Language: English. Entry Date: 20081205. Revision Date: 20150711. Publication Type: Journal Article; interview. Supplement Title: Jul/Aug2008 Web Exclusives. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Government Regulations
KW - Nanomedicine
KW - United States Food and Drug Administration
KW - Assistive Technology Devices
KW - Diagnostic Imaging
KW - Drug Administration
KW - Outcomes (Health Care)
KW - Patient Safety
KW - Product Surveillance
KW - Risk Factors
SP - w315
EP - 7
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Cutting-edge research in nanomedicine dominates studies in drug delivery, medical imaging, and the development of new devices. Materials and devices the size of molecules, and even individual atoms, make it possible to see a tumor when it is no more than a few atoms in size. By using material in this size range, drugs can go directly to tumors or inflamed arteries, bypassing healthy tissue. In this interview Norris Alderson of the Food and Drug Administration discusses the present and future state of nanomedicine as it applies to health care, taking into consideration benefits, risks, and how much is still unknown.
SN - 0278-2715
AD - Office of Science and Health Coordination, Food and Drug Administration, Rockville, Maryland
U2 - PMID: 18559355.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105707265&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Ramachandra, B.
AU - Bias, C-A.
AU - Alberth, D.
AU - Doremus, S.
AU - Williams, A.
AU - Snead, K.
AU - Azzam, N.
AU - Petullo, C.
AU - Meck, R.
AU - Powers, G.
T1 - MULTI-AGENCY RADIATION SURVEY AND ASSESSMENT OF MATERIALS AND EQUIPMENT MANUAL.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07/02/2008 Supplement
VL - 95
M3 - Abstract
SP - S16
EP - S16
SN - 00179078
AB - An abstract of the paper "Multi-Agency Radiation Survey and Assessment of Materials and Equipment Manual," by B. Ramachandra, C. A. Bias, D. Alberth, S. Doremus, A. Williams, K. Snead, N. Azzam, C. Petullo, R. Meck and G. Powers is presented.
KW - Radiation measurements -- Abstracts
N1 - Accession Number: 33009632; Ramachandra, B. 1; Bias, C-A. 1; Alberth, D. 2; Doremus, S. 3; Williams, A. 4; Snead, K. 5; Azzam, N. 5; Petullo, C. 6; Meck, R. 7; Powers, G. 7; Affiliations: 1: U.S. Air Force, 1200 Pennsylvania Avenue, NW, MC 6608J, Washington, DC 20460; 2: U.S. Army, 1200 Pennsylvania Avenue, NW, MC 6608J, Washington, DC 20460; 3: U.S. Navy, 1200 Pennsylvania Avenue, NW, MC 6608J, Washington, DC 20460; 4: U.S. Department of Energy, 1200 Pennsylvania Avenue, NW, MC 6608J, Washington, DC 20460; 5: U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW, MC 6608J, Washington, DC 20460; 6: U.S. Public Health Service (U.S. Environmental Protection Agency; 7: U.S. Nuclear Regulatory Commission; Issue Info: 2008 Supplement, Vol. 95, pS16; Subject Term: Radiation measurements -- Abstracts; Number of Pages: 1/3p; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Hoover, M. D.
T1 - NANOPARTICLE ISSUES FOR THE HEALTH PHYSICIST: INSIGHTS FROM THE NIOSH NANOTECHNOLOGY RESEARCH PROGRAM.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07/02/2008 Supplement
VL - 95
M3 - Abstract
SP - S79
EP - S79
SN - 00179078
AB - An abstract of the article "Nanoparticle Issues for the Health Physicist: Insights From the NIOSH Nanotechnology Research Program," by M. D. Hoover is presented.
KW - Nanoparticles
N1 - Accession Number: 33009798; Hoover, M. D. 1; Affiliations: 1: CDC/National Institute for Occupational Safety and Health, 7 Cedarwood Drive, Morgantown, WV 26505-3628; Issue Info: 2008 Supplement, Vol. 95, pS79; Subject Term: Nanoparticles; Number of Pages: 1/2p; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Hoover, M. D.
T1 - UPDATE ON THE NIOSH DIRECT READING METHODS INITIATIVE.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07/02/2008 Supplement
VL - 95
M3 - Abstract
SP - S84
EP - S84
SN - 00179078
AB - An abstract of the article "Update on the NIOSH Direct Reading Methods Initiative," by M. D. Hoover is presented.
KW - Industrial hygiene
N1 - Accession Number: 33009810; Hoover, M. D. 1; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: 2008 Supplement, Vol. 95, pS84; Thesaurus Term: Industrial hygiene; Number of Pages: 1/3p; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Hoover, M. D.
AU - Howie, W. L.
AU - Miller, A. L.
T1 - RADIATION PROTECTION FOR URANIUM MINERS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07/02/2008 Supplement
VL - 95
M3 - Abstract
SP - S84
EP - S84
SN - 00179078
AB - An abstract of the article "Radiation Protection for Uranium Miners," by M. D. Hoover, W. L. Howie and A. L. Miller is presented.
KW - Mine safety
KW - Uranium mines & mining
N1 - Accession Number: 33009811; Hoover, M. D. 1; Howie, W. L.; Miller, A. L.; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: 2008 Supplement, Vol. 95, pS84; Thesaurus Term: Mine safety; Thesaurus Term: Uranium mines & mining; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 212291 Uranium-Radium-Vanadium Ore Mining; NAICS/Industry Codes: 213119 Other support activities for mining; Number of Pages: 1/3p; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Kase, K. R.
AU - Rosenstein, M.
AU - Miller, K. L.
AU - Quinn, D. M.
AU - Strom, D. J.
AU - Suleiman, O.
AU - Thomadsen, B. R.
T1 - IONIZING RADIATION EXPOSURE OF THE U.S. POPULATION.
JO - Health Physics
JF - Health Physics
Y1 - 2008/07/02/2008 Supplement
VL - 95
M3 - Abstract
SP - S96
EP - S96
SN - 00179078
AB - An abstract of the article "Ionizing Radiation Exposure of the U.S. Population," by K. R. Kase, M. Rosenstein, K. L. Miller, D. M. Quinn, D. J. Strom, O. Suleiman and B. R. Thomadsen is presented.
KW - Radiation exposure
N1 - Accession Number: 33009845; Kase, K. R. 1; Rosenstein, M. 1; Miller, K. L. 2; Quinn, D. M. 3; Strom, D. J. 4; Suleiman, O. 5; Thomadsen, B. R. 6; Affiliations: 1: National Council on Radiation Protection and Measurements, 955 N. California Avenue, Palo Alto, CA 94303-3407; 2: Hershey Medical Center; 3: DAQ, Inc.; 4: Pacific Northwest Laboratories; 5: U.S. Food and Drug Administration; 6: University of Wisconsin; Issue Info: 2008 Supplement, Vol. 95, pS96; Thesaurus Term: Radiation exposure; Number of Pages: 1/3p; Document Type: Abstract
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105689105
T1 - How many days of pedometer use reliably predict the annual activity of the elderly? The Nakanojo Study...7th World Congress on Aging and Physical Activity
AU - Togo F
AU - Watanabe E
AU - Park H
AU - Yasunaga A
AU - Park S
AU - Shephard RJ
AU - Aoyagi Y
Y1 - 2008/07/02/Jul2008 Supplement
N1 - Accession Number: 105689105. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; abstract; research. Supplement Title: Jul2008 Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Gerontologic Care. NLM UID: 9415639.
KW - Pedometers
KW - Physical Activity -- Trends -- In Old Age
KW - Aged
KW - Analysis of Variance
KW - Descriptive Statistics
KW - Female
KW - Male
KW - Spearman's Rank Correlation Coefficient
KW - Human
SP - S35
EP - S35
JO - Journal of Aging & Physical Activity
JF - Journal of Aging & Physical Activity
JA - J AGING PHYS ACTIVITY
VL - 16
CY - Champaign, Illinois
PB - Human Kinetics Publishers, Inc.
SN - 1063-8652
AD - Dept of Work Stress Control, Japan National Institute of Occupational Safety and Health
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bruce D. Pacolay
AU - Jason E. Ham
AU - James E. Slaven
AU - J. R. Wells
T1 - Feasibility of detection and quantification of gas-phase carbonyls in indoor environments using PFBHA derivatization and solid-phase microextraction (SPME).
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/07/02/
VL - 10
IS - 7
M3 - Article
SP - 853
EP - 860
SN - 14640325
AB - Solid-phase microextraction (SPME) was evaluated for the detection and quantification of the gas-phase carbonyls: citronellal, glyoxal, methylglyoxal, and β-ionone. Prepared air samples containing the carbonyl compounds were collected at a flow rate of 2.8 L min−1 in an impinger containing a 25% reagent water/75% methanol collection liquid. The aqueous samples were then derivatized with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA), extracted with a PDMS/DVB coated SPME fiber, and analyzed by GC-MS. Detection limits with a sample air volume of 76 L were calculated to be 0.03 ppbv, 0.34 ppbv, 0.12 ppbv, and 0.28 ppbv for citronellal, glyoxal, methylglyoxal, and β-ionone, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Saltwater solutions
KW - Feasibility studies
KW - Chemical reactions
KW - Carbonyl compounds -- Environmental aspects
N1 - Accession Number: 33176123; Bruce D. Pacolay 1; Jason E. Ham 1; James E. Slaven 2; J. R. Wells 1; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health1095 Willowdale Road MS-3030 Morgantown USA ozw0@cdc.gov; 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and HealthWillowdale Road MS-3030 Morgantown USA; Issue Info: Jul2008, Vol. 10 Issue 7, p853; Thesaurus Term: Saltwater solutions; Subject Term: Feasibility studies; Subject Term: Chemical reactions; Subject Term: Carbonyl compounds -- Environmental aspects; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105965100
T1 - Alcohol use, injuries, and prenatal visits during three successive pregnancies among American Indian women on the Northern Plains who have children with fetal alcohol syndrome or incomplete fetal alcohol syndrome.
AU - Kvigne VL
AU - Leonardson GR
AU - Borzelleca J
AU - Brock E
AU - Neff-Smith M
AU - Welty TK
Y1 - 2008/07/02/Jul2008 Supplement 1
N1 - Accession Number: 105965100. Language: English. Entry Date: 20081212. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Supplement Title: Jul2008 Supplement 1. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Pediatric Care. Grant Information: Supported by the Indian Health Service and Centers for Disease Control and Prevention. NLM UID: 9715672.
KW - Alcohol Drinking -- In Pregnancy
KW - Fetal Alcohol Syndrome
KW - Native Americans
KW - Wounds and Injuries -- In Pregnancy
KW - Adult
KW - Case Control Studies
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Health Services, Indigenous
KW - International Classification of Diseases
KW - McNemar's Test
KW - Medical Records
KW - Odds Ratio
KW - Pregnancy
KW - Pregnancy Outcomes
KW - Prenatal Care
KW - Record Review
KW - Retrospective Design
KW - Smoking
KW - T-Tests
KW - Human
SP - S37
EP - 45
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 12
CY - ,
PB - Springer Science & Business Media B.V.
AB - Introduction The purpose of the study was to compare three sequential pregnancies of American Indian women who have children with FAS or children with incomplete FAS with women who did not have children with FAS. Methods Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome (FAS) (Study 1) or incomplete FAS (Study 2) in 1981-1993. Three successive pregnancies ending in live births of 43 case mothers who had children with FAS, and 35 case mothers who had children with incomplete FAS were compared to the pregnancies of 86 and 70 control mothers who did not have children with FAS, respectively, in the two studies. Prenatal records were abstracted for the index child (child with FAS or incomplete FAS) and siblings born just before and just after the index child, and comparable prenatal records for the controls. Results Compared to the controls, significantly more case mothers used alcohol before and after all three pregnancies and during pregnancy with the before sibling and the index child. Mothers who had children with FAS reduced their alcohol use during the pregnancy following the birth of the index child. All Study 1 case mothers (100%) and 60% of Study 2 case mothers used alcohol during the pregnancy with the index child compared to 20 and 9% of respective control mothers. More study 1 case mothers experienced unintentional injuries (OR 9.50) and intentional injuries during the index pregnancy (OR 9.33) than the control mothers. Most case mothers began prenatal care in the second trimester. Conclusions Alcohol use was documented before, during and after each of the three pregnancies. Women of child-bearing age should be screened for alcohol use whenever they present for medical services. Mothers who had a child with FAS decreased their alcohol consumption with the next pregnancy, a finding that supports the importance of prenatal screening throughout pregnancy. Women who receive medical care for injuries should be screened for alcohol use and referred for appropriate treatment. Protective custody, case management and treatment services need to be readily available for women who use alcohol.
SN - 1092-7875
AD - Aberdeen Area Indian Health Service, Sioux Falls, SD, USA
U2 - PMID: 18498046.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hawrani, Ayman
AU - Howe, Robin A.
AU - Waish, Timothy R.
AU - Dempsey, Christopher E.
T1 - Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008/07/04/
VL - 283
IS - 27
M3 - Article
SP - 18636
EP - 18645
SN - 00219258
AB - We recently described a novel antimicrobial peptide, RTA3, derived from the commensal organism Streptococcus mitis, with strong anti-Gram-negative activity, low salt sensitivity, and minimal mammalian cell toxicity in vitro and in vivo. This peptide conforms to the positively charged, amphipathic helical peptide motif, but has a positively charged amino acid (Arg-5) on the nonpolar face of the helical structure that is induced upon membrane binding. We surmised that disruption of the hydrophobic face with a positively charged residue plays a role in minimizing eukaryotic cell toxicity, and we tested this using a mutant with an R5L substitution. The greatly enhanced toxicity in the mutant peptide correlated with its ability to bind and adopt helical conformations upon interacting with neutral membranes; the wild type peptide RTA3 did not bind to neutral membranes (binding constant reduced by at least 1000-fold). Spectroscopic analysis indicates that disruption of the hydrophobic face of the parent peptide is accommodated in negatively charged membranes without partial peptide unfolding. These observations apply generally to amphipathic helical peptides of this class as we obtained similar results with a peptide and mutant pair (Chen, Y., Mant, C. T., Farmer, S. W., Hancock, R. E., Vasil, M. L., and Hodges, R. S. (2005) 1. Biol. Chem. 280, 12316-12329) having similar structural properties. In contrast to previous interpretations, we demonstrate that these peptides simply do not bind well to membranes (like those of eukaryotes) with exclusively neutral lipids in their external bilayer leaflet. We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL-mediated cytotoxicity
KW - ANTI-infective agents
KW - PEPTIDES
KW - AMINO acids
KW - GRAM-negative bacteria
KW - STREPTOCOCCUS
N1 - Accession Number: 33234065; Hawrani, Ayman 1 Howe, Robin A. 2 Waish, Timothy R. 3 Dempsey, Christopher E. 4; Email Address: c.dempsey@bris.ac.uk; Affiliation: 1: Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD 2: National Public Health Service Cardiff, University Hospital of Wales, Cardiff CF14 4XW 3: Department of Medical Microbiology, Cardiff University, Cardiff CF14 4XN, United Kingdom 4: Biochemistry Department, Bristol University, Bristol BS8 1TD; Source Info: 7/4/2008, Vol. 283 Issue 27, p18636; Subject Term: CELL-mediated cytotoxicity; Subject Term: ANTI-infective agents; Subject Term: PEPTIDES; Subject Term: AMINO acids; Subject Term: GRAM-negative bacteria; Subject Term: STREPTOCOCCUS; Number of Pages: 10p; Illustrations: 3 Charts, 8 Graphs; Document Type: Article
L3 - 10.1074/jbc.M709154200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schaefer, Mark
AU - Baker, D. James
AU - Gibbons, John H.
AU - Groat, Charles G.
AU - Kennedy, Donald
AU - Kennel, Charles F.
AU - Rejeski, David
T1 - An Earth Systems Science Agency.
JO - Science
JF - Science
Y1 - 2008/07/04/
VL - 321
IS - 5885
M3 - Article
SP - 44
EP - 45
SN - 00368075
AB - The article profiles Earth Systems Science Agency, a joint program by the National Oceanic and Atmospheric Administration (NOAA) and the United States Geological Survey. The establishment of the new organization is part of the United States effort in addressing serious environmental and economic challenges. Earth Systems Science Agency is a science-based agency responsible for studying and overseeing activities in the U.S. which concern climate change, sea-level rise, as well as altered weather pattern.
KW - CLIMATIC changes
KW - GOVERNMENT agencies
KW - CLIMATOLOGY
KW - WEATHER forecasting
KW - STATISTICAL weather forecasting
KW - GLOBAL temperature changes
KW - UNITED States
KW - UNITED States. National Oceanic & Atmospheric Administration
KW - GEOLOGICAL Survey (U.S.)
N1 - Accession Number: 33406876; Schaefer, Mark 1 Baker, D. James 2; Email Address: djamesbaker@comcast.net Gibbons, John H. 3; Email Address: jackgibbons@hughes.net Groat, Charles G. 4; Email Address: cgroat@mail.utexas.ed Kennedy, Donald 5; Email Address: kennedy@stanford.edu Kennel, Charles F. 6; Email Address: ckennel@ucsd.edu Rejeski, David 7; Email Address: david.rejeski@wilsoncenter.org; Affiliation: 1: Deputy Assistant Secretary of the Interior, Acting Director of the U.S. Geological Survey 2: Administrator, National Oceanic and Atmospheric Association 3: Director, White House Office of Science and Technology Policy, Science Adviser to the President 4: Director, U.S. Geological Survey, National Aeronautics and Space Administration, Director of Mission to Planet Earth 5: Commissioner, Food and Drug Administration, National Aeronautics and Space Administration, Director of Mission to Planet Earth 6: Associate Administrator, National Aeronautics and Space Administration, Director of Mission to Planet Earth 7: Office of Science and Technology Policy and Council on Environmental Quality; Source Info: 7/4/2008, Vol. 321 Issue 5885, p44; Subject Term: CLIMATIC changes; Subject Term: GOVERNMENT agencies; Subject Term: CLIMATOLOGY; Subject Term: WEATHER forecasting; Subject Term: STATISTICAL weather forecasting; Subject Term: GLOBAL temperature changes; Subject Term: UNITED States; Company/Entity: UNITED States. National Oceanic & Atmospheric Administration Company/Entity: GEOLOGICAL Survey (U.S.); NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 541990 All Other Professional, Scientific, and Technical Services; NAICS/Industry Codes: 924120 Administration of Conservation Programs; Number of Pages: 2p; Document Type: Article
L3 - 10.1126/science.1160192
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weisz, Adrian
AU - Ito, Yoichiro
T1 - Preparative purification of 4-hydroxy-1-naphthalenesulfonic acid sodium salt by high-speed counter-current chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/07/11/
VL - 1198-1199
M3 - Article
SP - 232
EP - 234
SN - 00219673
AB - Abstract: Among the many applications of 4-hydroxy-1-naphthalenesulfonic acid sodium salt (HNSA, CAS No. 6099-57-6) is its use as a common intermediate in the manufacture of dyes used as color additives. In order to develop an HPLC method to analyze HNSA in such additives, it was necessary to obtain pure HNSA as a reference material. This compound is only commercially available in “technical” or “practical” grade (∼70–85% purity). Unsatisfactory results were encountered during the attempts to eliminate impurities using published preparative purification methods. The current work demonstrates the successful application of high-speed counter-current chromatography (HSCCC) to the preparative purification of “practical” grade HNSA. The purifications of 0.55g and 1.00g portions were achieved by using a solvent system that consisted of n-butanol/water (1:1), acidified with 0.2% trifluoroacetic acid. In contrast to the procedure involved in previous HSCCC separations of aromatic sulfonates, it was not necessary to add a ligand and a retainer to the solvent system for these separations. The resulting yields were 320mg and 485mg of HNSA, respectively, of over 99% purity. Elemental analysis, HPLC (at 240nm), UV and high-resolution MS analyses confirmed the identity and purity of the HNSA obtained. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SODIUM salts
KW - CHROMATOGRAPHIC analysis
KW - ADDITIVES
KW - CONTAMINATION (Technology)
KW - 4-Hydroxy-1-naphthalenesulfonic acid sodium salt
KW - Color additive intermediate
KW - Counter-current chromatography
KW - Purification
N1 - Accession Number: 32742277; Weisz, Adrian 1; Email Address: adrian.weisz@fda.hhs.gov Ito, Yoichiro 2; Affiliation: 1: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA 2: Bioseparation Technology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Jul2008, Vol. 1198-1199, p232; Subject Term: SODIUM salts; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ADDITIVES; Subject Term: CONTAMINATION (Technology); Author-Supplied Keyword: 4-Hydroxy-1-naphthalenesulfonic acid sodium salt; Author-Supplied Keyword: Color additive intermediate; Author-Supplied Keyword: Counter-current chromatography; Author-Supplied Keyword: Purification; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.chroma.2008.05.060
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martinez, Marilyn
AU - Rathbone, Michael
AU - Burgess, Diane
AU - Huynh, Mai
T1 - In vitro and in vivo considerations associated with parenteral sustained release products: A review based upon information presented and points expressed at the 2007 Controlled Release Society Annual Meeting
JO - Journal of Controlled Release
JF - Journal of Controlled Release
Y1 - 2008/07/14/
VL - 129
IS - 2
M3 - Article
SP - 79
EP - 87
SN - 01683659
N1 - Accession Number: 32731114; Martinez, Marilyn 1; Email Address: marilyn.martinez@fda.hhs.gov Rathbone, Michael 2 Burgess, Diane 3 Huynh, Mai 1; Affiliation: 1: US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland 20855, United States 2: InterAg, 558 Te Rapa Road, PO Box 20055, Hamilton, New Zealand 3: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06268, United States; Source Info: Jul2008, Vol. 129 Issue 2, p79; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jconrel.2008.04.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sander, L. C.
AU - Putzbach, K.
AU - Nelson, B. C.
AU - Rimmer, C. A.
AU - Bedner, M.
AU - Thomas, J. Brown
AU - Porter, B. J.
AU - Wood, L. J.
AU - Schantz, M. M.
AU - Murphy, K. E.
AU - Sharpless, K. E.
AU - Wise, S. A.
AU - Yen, J. H.
AU - Siitonen, P. H.
AU - Evans, R. L.
AU - Pho, A. Nguyen
AU - Roman, M. C.
AU - Betz, J. M.
T1 - Certification of standard reference materials containing bitter orange.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2008/07/15/
VL - 391
IS - 6
M3 - Article
SP - 2023
EP - 2034
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - A suite of three dietary supplement standard reference materials (SRMs) containing bitter orange has been developed, and the levels of five alkaloids and caffeine have been measured by multiple analytical methods. Synephrine, octopamine, tyramine, N-methyltyramine, hordenine, total alkaloids, and caffeine were determined by as many as six analytical methods, with measurements performed at the National Institute of Standards and Technology and at two collaborating laboratories. The methods offer substantial independence, with two types of extractions, two separation methods, and four detection methods. Excellent agreement was obtained among the measurements, with data reproducibility for most methods and analytes better than 5% relative standard deviation. The bitter-orange-containing dietary supplement SRMs are intended primarily for use as measurement controls and for use in the development and validation of analytical methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements
KW - ORANGE (Fruit)
KW - CAFFEINE
KW - ALKALOIDS
KW - Foods/beverages
KW - High-performance liquid chromatography
KW - Natural products
KW - Organic compounds
KW - Reference materials
KW - NATIONAL Institute of Standards & Technology (U.S.)
N1 - Accession Number: 32785881; Sander, L. C. 1; Email Address: lane.sander@nist.gov Putzbach, K. 1,2 Nelson, B. C. 1 Rimmer, C. A. 1 Bedner, M. 1 Thomas, J. Brown 1 Porter, B. J. 1 Wood, L. J. 1 Schantz, M. M. 1 Murphy, K. E. 1 Sharpless, K. E. 1 Wise, S. A. 1 Yen, J. H. 3 Siitonen, P. H. 4 Evans, R. L. 4 Pho, A. Nguyen 5 Roman, M. C. 6,7 Betz, J. M. 8; Affiliation: 1: National Institute of Standards and Technology, Chemical Science and Technology Laboratory, 100 Bureau Drive, MS 8392, Gaithersburg, MD 20899-8392, USA 2: RCC Ltd., Zelgliweg 1, 4452 Itingen, Switzerland 3: National Institute of Standards and Technology, Information Technology Laboratory, 100 Bureau Drive, MS 8392, Gaithersburg, MD 20899-8392, USA 4: National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079-9502, USA 5: Center for Drug Evaluation and Research (CDER), Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 6: ChromaDex, Inc., Research and Development, 13161 56th Ct. Ste. 201, Clearwater, FL 33760, US 7: Tampa Bay Analytical Research, Inc., 10810 72nd St. STE 206, Largo, FL 33777, USA 8: Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Room 3B01, Bethesda, MD 20892, USA; Source Info: Jul2008, Vol. 391 Issue 6, p2023; Subject Term: DIETARY supplements; Subject Term: ORANGE (Fruit); Subject Term: CAFFEINE; Subject Term: ALKALOIDS; Author-Supplied Keyword: Foods/beverages; Author-Supplied Keyword: High-performance liquid chromatography; Author-Supplied Keyword: Natural products; Author-Supplied Keyword: Organic compounds; Author-Supplied Keyword: Reference materials; Company/Entity: NATIONAL Institute of Standards & Technology (U.S.); NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 111310 Orange Groves; Number of Pages: 12p; Illustrations: 2 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s00216-008-2074-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stefaniak, Aleksandr B.
AU - Turk, Gregory C.
AU - Dickerson, Robert M.
AU - Hoover, Mark D.
T1 - Size-selective poorly soluble particulate reference materials for evaluation of quantitative analytical methods.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2008/07/15/
VL - 391
IS - 6
M3 - Article
SP - 2071
EP - 2077
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - Owing to the absence of readily available certified particulate reference materials (RMs), most analytical methods used to determine particulate contaminant levels in workplace or other environments are validated using solution RMs, which do not assess the robustness of the digestion step for all forms and sizes of particles in a sample. A library of particulate RMs having a range of chemical forms and particle sizes is needed to support a shift in method evaluation strategies to include both solution and particulate RMs. In support of creating this library, we characterized bulk and physically size separated fractions of beryllium oxide (BeO) particles recovered from the machining fluid sludge of an industrial ceramic products grinding operation. Particles were large agglomerates of compact, crystalline BeO primary particles having diameters on the order of several micrometers. As expected, the particle surface area was independent of sieve size, with a range from 3.61 m2/g (53–63-μm fraction) to 4.82 m2/g (355–600-μm fraction). The density was near the theoretical value (3.01 g/cm3). The data support more detailed characterization of the sludge materials for use as size-selective RMs. This work illustrates an approach that can be used to develop RMs that are difficult to digest. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLLUTANTS
KW - PARTICULATE matter
KW - WORK environment
KW - BERYLLIUM oxide
KW - CERAMICS
KW - Beryllium
KW - Digestion
KW - Method validation
KW - Particulate
KW - Reference materials
N1 - Accession Number: 32785900; Stefaniak, Aleksandr B. 1; Email Address: astefaniak@cdc.gov Turk, Gregory C. 2 Dickerson, Robert M. 3 Hoover, Mark D. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdate Road, Morgantown, WV 26505, USA 2: National Institute of Standards and Technology, Gaithersburg, MD 20899, USA 3: Los Alamos National Laboratory, Los Alamos, NM 87545, USA; Source Info: Jul2008, Vol. 391 Issue 6, p2071; Subject Term: POLLUTANTS; Subject Term: PARTICULATE matter; Subject Term: WORK environment; Subject Term: BERYLLIUM oxide; Subject Term: CERAMICS; Author-Supplied Keyword: Beryllium; Author-Supplied Keyword: Digestion; Author-Supplied Keyword: Method validation; Author-Supplied Keyword: Particulate; Author-Supplied Keyword: Reference materials; NAICS/Industry Codes: 327110 Pottery, Ceramics, and Plumbing Fixture Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00216-008-1870-x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soto, Carissa M.
AU - Martin, Brett D.
AU - Sapsford, Kim E.
AU - Blum, Amy Szuchmacher
AU - Ratna, Banahalli R.
T1 - Toward Single Molecule Detection of Staphylococcal Enterotoxin B: Mobile Sandwich Immunoassay on Gliding Microtubules.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2008/07/15/
VL - 80
IS - 14
M3 - Article
SP - 5433
EP - 5440
SN - 00032700
AB - An immunoassay based on gliding microtubules (MTs) is described for the detection of staphylococcal enterotoxin B. Detection is performed in a sandwich immunoassay format. Gliding microtubules carry the antigen-specific "capture" antibody, and bound analyte is detected using a fluorescent viral scaffold as the tracer. A detailed modification scheme for the MTs postpolymerization is described along with corresponding quantification by fluorescence spectroscopy. The resultant antibody-MTs maintain their morphology and gliding capabilities. We report a limit of detection down to 0.5 ng/mL during active transport in a 30 mm assay time and down to 1 ng/mL on static surfaces. This study demonstrates the kinesin/MT-mediated capture, transport, and detection of the biowarfare agent SEB in a microfluidic format. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STAPHYLOCOCCAL diseases
KW - ENTEROTOXINS
KW - IMMUNOASSAY
KW - MICROTUBULES
KW - IMMUNOGLOBULINS
KW - ANTIGENS
KW - FLUORESCENCE spectroscopy
KW - POLYMERIZATION
KW - ACTIVE biological transport
KW - BIOLOGICAL warfare
N1 - Accession Number: 33918843; Soto, Carissa M. 1; Email Address: carissa.soto@nrl.navy.mil Martin, Brett D. 1 Sapsford, Kim E. 2,3 Blum, Amy Szuchmacher 1 Ratna, Banahalli R. 1; Affiliation: 1: Naval Research Laboratory. 2: George Mason University. 3: U.S. Food and Drug Administration, CDRH/OSEL/DB, Building 64 HFZ-110, 10903 New Hampshire Ave., Silver Spring, MD 20993.; Source Info: 7/15/2008, Vol. 80 Issue 14, p5433; Subject Term: STAPHYLOCOCCAL diseases; Subject Term: ENTEROTOXINS; Subject Term: IMMUNOASSAY; Subject Term: MICROTUBULES; Subject Term: IMMUNOGLOBULINS; Subject Term: ANTIGENS; Subject Term: FLUORESCENCE spectroscopy; Subject Term: POLYMERIZATION; Subject Term: ACTIVE biological transport; Subject Term: BIOLOGICAL warfare; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cowley, Siobhán C.
AU - Goldberg, Michael F.
AU - Ho, J. Anthony
AU - Elkins, Karen L.
T1 - The Membrane Form of Tumor Necrosis Factor Is Sufficient to Mediate Partial Innate Immunity to Francisella tularensis Live Vaccine Strain.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/07/15/
VL - 198
IS - 2
M3 - Article
SP - 284
EP - 292
SN - 00221899
AB - Here we characterize Francisella tularensis live vaccine strain (LVS) infection in total tumor necrosis factor (TNF) knockout (KO) mice and in transgenic mice expressing only the membrane form of TNF (memTNF). MemTNF mice, but not TNF KO mice, survived low-dose, sublethal LVS infections. Splenic nitric oxide production was impaired in infected memTNF mice and was absent in infected TNF KO mice. Spleen cell production of interferon-γ, RANTES,and monocyte chemotactic protein-1 was elevated in TNFKO mice, compared with that in WT mice, by days 4-5 after infection, along with transiently increased numbers of CCR2+ cells, whereas memTNF mice had an intermediate phenotype. By day 6 after infection, TNF KO mice, but not memTNF mice, exhibited massive apoptosis in spleens and livers, which shortly preceded their death. Thus, mem TNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUMOR necrosis factor
KW - NATURAL immunity
KW - FRANCISELLA tularensis
KW - TRANSGENIC mice
KW - RESEARCH
KW - CHEMOKINES
KW - MONOCYTES
KW - PHENOTYPE
KW - NITRIC oxide
KW - APOPTOSIS
N1 - Accession Number: 33114355; Cowley, Siobhán C. 1; Email Address: siobhan.cowley@fda.hhs.gov Goldberg, Michael F. 1 Ho, J. Anthony 1 Elkins, Karen L. 1; Email Address: karen.elkins@fda.hhs.gov; Affiliation: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration; Source Info: 7/15/2008, Vol. 198 Issue 2, p284; Subject Term: TUMOR necrosis factor; Subject Term: NATURAL immunity; Subject Term: FRANCISELLA tularensis; Subject Term: TRANSGENIC mice; Subject Term: RESEARCH; Subject Term: CHEMOKINES; Subject Term: MONOCYTES; Subject Term: PHENOTYPE; Subject Term: NITRIC oxide; Subject Term: APOPTOSIS; Number of Pages: 9p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1086/589620
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105799123
T1 - The membrane form of tumor necrosis factor is sufficient to mediate partial innate immunity to Francisella tularensis live vaccine strain.
AU - Cowley SC
AU - Goldberg MF
AU - Ho JA
AU - Elkins KL
Y1 - 2008/07/15/
N1 - Accession Number: 105799123. Language: English. Entry Date: 20080829. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Center for Biologics Evaluation and Research, US Food and Drug Administration. NLM UID: 0413675.
KW - Bacterial Vaccines
KW - Tularemia -- Prevention and Control
KW - Tumor Necrosis Factor -- Metabolism
KW - Animal Studies
KW - Apoptosis
KW - Aspartate Aminotransferase -- Blood
KW - Cytokines -- Metabolism
KW - Flow Cytometry
KW - Funding Source
KW - Immunohistochemistry
KW - Mice
KW - Nitric Oxide -- Metabolism
KW - Reactive Oxygen Species
KW - Survival
SP - 284
EP - 292
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 198
IS - 2
PB - Oxford University Press / USA
AB - Here we characterize Francisella tularensis live vaccine strain (LVS) infection in total tumor necrosis factor (TNF) knockout (KO) mice and in transgenic mice expressing only the membrane form of TNF (memTNF). MemTNF mice, but not TNF KO mice, survived low-dose, sublethal LVS infections. Splenic nitric oxide production was impaired in infected memTNF mice and was absent in infected TNF KO mice. Spleen cell production of interferon-gamma, RANTES, and monocyte chemotactic protein-1 was elevated in TNF KO mice, compared with that in WT mice, by days 4-5 after infection, along with transiently increased numbers of CCR2(+) cells, whereas memTNF mice had an intermediate phenotype. By day 6 after infection, TNF KO mice, but not memTNF mice, exhibited massive apoptosis in spleens and livers, which shortly preceded their death. Thus, memTNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice. Copyright © 2008 Infectious Diseases Society of America
SN - 0022-1899
AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration; siobhan.cowley@fda.hhs.gov
U2 - PMID: 18593295.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bowyer, J.F.
AU - Latendresse, J.R.
AU - Delongchamp, R.R.
AU - Muskhelishvili, L.
AU - Warbritton, A.R.
AU - Thomas, M.
AU - Tareke, E.
AU - McDaniel, L.P.
AU - Doerge, D.R.
T1 - The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/07/15/
VL - 230
IS - 2
M3 - Article
SP - 208
EP - 215
SN - 0041008X
AB - Abstract: Acrylamide (AA) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. The observation of cancer in endocrine-responsive tissues in Fischer 344 rats has prompted hypotheses of hormonal dysregulation, as opposed to DNA damage, as the mechanism for tumor induction by AA. The current investigation examines possible evidence for disruption of the hypothalamic–pituitary–thyroid axis from 14 days of repeated exposure of male Fischer 344 rats to doses of AA that range from one that is carcinogenic after lifetime exposure (2.5 mg/kg/d), an intermediate dose (10 mg/kg/d), and a high dose (50 mg/kg/d) that is neurotoxic for this exposure time. The endpoints selected include: serum levels of thyroid and pituitary hormones; target tissue expression of genes involved in hormone synthesis, release, and receptors; neurotransmitters in the CNS that affect hormone homeostasis; and histopathological evaluation of target tissues. These studies showed virtually no evidence for systematic alteration of the hypothalamic–pituitary–thyroid axis and do not support hormone dysregulation as a plausible mechanism for AA-induced thyroid cancer in the Fischer 344 rat. Specifically, there were no significant changes in: 1) mRNA levels in hypothalamus or pituitary for TRH, TSH, thyroid hormone receptor α and β, as well 10 other hormones or releasing factors; 2) mRNA levels in thyroid for thyroglobulin, thyroid peroxidase, sodium iodide symporter, or type I deiodinases; 3) serum TSH or T3 levels (T4 was decreased at high dose only); 4) dopaminergic tone in the hypothalamus and pituitary or importantly 5) increased cell proliferation (Mki67 mRNA and Ki-67 protein levels were not increased) in thyroid or pituitary. These negative findings are consistent with a genotoxic mechanism of AA carcinogenicity based on metabolism to glycidamide and DNA adduct formation. Clarification of this mechanistic dichotomy may be useful in human cancer risk assessments for AA. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - ACRYLAMIDE
KW - PATHOLOGICAL histology
KW - RATS as laboratory animals
KW - Acrylamide
KW - Cancer
KW - Dopamine
KW - Hypothalamus
KW - Pituitary
KW - Thyroid
N1 - Accession Number: 32738178; Bowyer, J.F. 1 Latendresse, J.R. 2 Delongchamp, R.R. 3 Muskhelishvili, L. 2 Warbritton, A.R. 2 Thomas, M. 1 Tareke, E. 4 McDaniel, L.P. 5 Doerge, D.R. 6; Email Address: daniel.doerge@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA 2: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Toxicologic Pathology Associates, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Department of Epidemiology, University of Arkansas for Medical Sciences, College of Public Health, 4301 W Markham Street, #820, Little Rock, AR 72205, USA 4: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Personalized Nutrition and Medicine, 3900 NCTR Road, Jefferson, AR 72079, USA 5: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA 6: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Jul2008, Vol. 230 Issue 2, p208; Subject Term: GENE expression; Subject Term: ACRYLAMIDE; Subject Term: PATHOLOGICAL histology; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Hypothalamus; Author-Supplied Keyword: Pituitary; Author-Supplied Keyword: Thyroid; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.taap.2008.02.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gabry, K. Eddie
T1 - THE ESTROGEN ELIXIR: A HISTORY OF HORMONE REPLACEMENT THERAPY IN AMERICA.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/07/16/
VL - 300
IS - 3
M3 - Book Review
SP - 335
EP - 336
SN - 00987484
AB - The article reviews the books "The Estrogen Elixir: A History of Hormone Replacement Therapy in America" by E. S. Watkins.
KW - MENOPAUSE -- Hormone therapy
KW - NONFICTION
KW - WATKINS, S.
KW - ESTROGEN Elixir: A History of Hormone Replacement Therapy in America, The (Book)
N1 - Accession Number: 33163119; Gabry, K. Eddie 1; Email Address: gabry@women-health.us; Affiliation: 1: Division of Metabolic and Endocrine Products, US Food and Drug Administration Center for Drug Evaluation and Research, Silver Spring, Maryland; Source Info: 7/16/2008, Vol. 300 Issue 3, p335; Subject Term: MENOPAUSE -- Hormone therapy; Subject Term: NONFICTION; Reviews & Products: ESTROGEN Elixir: A History of Hormone Replacement Therapy in America, The (Book); People: WATKINS, S.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mazurek, J. M.
AU - Wood, J. M.
T1 - Silicosis-Related Years of Potential Life Lost Before Age 65 Years -- United States, 1968-2005.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/07/18/
VL - 57
IS - 28
M3 - Article
SP - 771
EP - 775
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article looks at silicosis, a work-related disease caused by exposure to respirable crystalline silica in industries like construction and manufacturing. Data gathered in the U.S. from 1968 to 2005 related to years of potential life lost (YPLL) due to silicosis before the age of 65 are presented. It is also inferred that there was a decline in silicosis-attributable deaths among subjects aged 45-64 due to the implementation of industrial exposure standards and regulations.
KW - SILICOSIS
KW - LUNGS -- Dust diseases
KW - INDUSTRIAL hygiene
KW - SILICA
KW - UNITED States
N1 - Accession Number: 33336705; Mazurek, J. M. 1 Wood, J. M. 1; Affiliation: 1: Div Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 7/18/2008, Vol. 57 Issue 28, p771; Subject Term: SILICOSIS; Subject Term: LUNGS -- Dust diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: SILICA; Subject Term: UNITED States; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kimblin, Nicola
AU - Peters, Nathan
AU - Debrabant, Alain
AU - Secundino, Nagila
AU - Egen, Jackson
AU - Lawyer, Phillip
AU - Fay, Michael P.
AU - Kamhawi, Shaden
AU - Sacks, David
T1 - Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2008/07/22/
VL - 105
IS - 29
M3 - Article
SP - 10125
EP - 10130
SN - 00278424
AB - Leishmaniasis is transmitted between mammalian hosts by the bites of bloodsucking vector sand flies. The dose of parasites transmitted to the mammalian host has never been directly deter- mined. We developed a real-time PCR-based method to determine the number of Leishmania major parasites inoculated into the ears of living mice during feeding by individual infected flies (Phie-botomus duboscqi). The number of parasites transmitted varied over a wide range in the 58 ears in which Leishmania were detected and demonstrated a clear bimodal distribution. Most of the infected mice were inoculated with a low dose of <600 parasites. One in four received a higher dose of >1,000 and up to 100,000 cells. High-dose transmission was associated with a heavy midgut infection of >30,000 parasites, incomplete blood feeding, and transmission of a high percentage of the parasite load in the fly. To test the impact of inoculum size on infection outcome, we com- pared representative high- (5,000) and low- (100) dose intradermal needle infections in the ears of C57BL/6 mice. To mimic natural transmission, we used sand fly-derived metacyclic forms of L. major and preexposed the injection site to the bites of uninfected flies. Large lesions developed rapidly in the ears of mice receiving the high-dose inoculum. The low dose resulted in only minor pathology but a higher parasite titer in the chronic phase, and it established the host as an efficient long-term reservoir of infection back to vector sand flies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEISHMANIA
KW - LEISHMANIASIS
KW - SAND flies
KW - ANIMALS as carriers of disease
KW - BITES & stings
KW - PARASITES
KW - leishmaniasis
KW - parasites
KW - vectors bites
N1 - Accession Number: 33560922; Kimblin, Nicola 1 Peters, Nathan 1 Debrabant, Alain 2 Secundino, Nagila 1 Egen, Jackson 3 Lawyer, Phillip 1 Fay, Michael P. 4 Kamhawi, Shaden 1 Sacks, David 1; Email Address: dsacks@nih.gov; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2: Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 3: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 4: Laboratory of Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Source Info: 7/22/2008, Vol. 105 Issue 29, p10125; Subject Term: LEISHMANIA; Subject Term: LEISHMANIASIS; Subject Term: SAND flies; Subject Term: ANIMALS as carriers of disease; Subject Term: BITES & stings; Subject Term: PARASITES; Author-Supplied Keyword: leishmaniasis; Author-Supplied Keyword: parasites; Author-Supplied Keyword: vectors bites; Number of Pages: 6p; Illustrations: 1 Diagram, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1073/pnas.0802331105
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Niemann, Richard A.
AU - Anderson, David L.
T1 - Determination of iodide and thiocyanate in powdered milk and infant formula by on-line enrichment ion chromatography with photodiode array detection
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/07/25/
VL - 1200
IS - 2
M3 - Article
SP - 193
EP - 197
SN - 00219673
AB - Abstract: Thiocyanate ranks after perchlorate as a potent inhibitor of iodide uptake by the thyroid but may be more concentrated in some food items such as milk products as to supersede perchlorate as the goitrogen of concern. A column-switching anion-exchange chromatographic method with UV spectral detection was developed to measure and confirm iodide and thiocyanate in powders of dry milk and infant formula. An aqueous solution was subjected to centrifugal ultrafiltration, the ultrafiltrate was cleaned up on a carbon solid-phase extraction column, and an aliquot was transferred to a precolumn for enrichment and subsequent injection onto an analytical column. In infant formula samples, thiocyanate was found at 2.0–5.1mg/kg in five of seven milk-based products and was not found in the other two nor in three soy-based products tested (0.2mg/kg LOQ); iodide was found at 0.3–1.3mg/kg (0.04mg/kg LOQ). In 13 dry milk samples, thiocyanate was found at 27–38mg/kg (1mg/kg LOQ), and iodide was found at 1.8–3.2mg/kg (0.2mg/kg LOQ). [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IODIDES
KW - HALIDES
KW - CESIUM iodide
KW - CHROMATOGRAPHIC analysis
KW - Infant formula
KW - Iodide
KW - Ion chromatography
KW - Milk
KW - Thiocyanate
N1 - Accession Number: 32982529; Niemann, Richard A.; Email Address: richard.niemann@fda.hhs.gov Anderson, David L. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Jul2008, Vol. 1200 Issue 2, p193; Subject Term: IODIDES; Subject Term: HALIDES; Subject Term: CESIUM iodide; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Infant formula; Author-Supplied Keyword: Iodide; Author-Supplied Keyword: Ion chromatography; Author-Supplied Keyword: Milk; Author-Supplied Keyword: Thiocyanate; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.chroma.2008.05.064
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105666484
T1 - Army occupational therapy in the Warrior Transition Unit.
AU - Erickson MW
AU - Secrest DS
AU - Gray AL
Y1 - 2008/07/28/2008 Jul 28 Suppl
N1 - Accession Number: 105666484. Language: English. Entry Date: 20081017. Revision Date: 20150711. Publication Type: Journal Article; case study; pictorial. Supplement Title: 2008 Jul 28 Suppl. Journal Subset: Allied Health; USA. Special Interest: Military/Uniformed Services; Occupational Therapy. NLM UID: 9602488.
KW - Blast Injuries -- Rehabilitation
KW - Community Reintegration
KW - Military Services
KW - Occupational Therapy
KW - Rehabilitation, Vocational
KW - Transitional Programs
KW - Female
KW - Functional Status
KW - Information Resources
KW - Male
KW - Occupational Therapy -- Methods
KW - Support, Psychosocial
SP - 10
EP - 14
JO - OT Practice
JF - OT Practice
JA - OT PRACT
VL - 13
IS - 13
CY - Bethesda, Maryland
PB - American Occupational Therapy Association
AB - Mary W. Erickson, Debra S. Secrest, and Amy L. Gray describe how OT is helping wounded soldiers transition back to active duty or civilian roles.
SN - 1084-4902
AD - Office of the Surgeon General, Health Policy and Services Division, United States Army
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Park, Jongseo
AU - Kim, Hong Kyu
AU - Son, Yongkeun
T1 - Glucose biosensor constructed from capped conducting microtubules of PEDOT
JO - Sensors & Actuators B: Chemical
JF - Sensors & Actuators B: Chemical
Y1 - 2008/07/28/
VL - 133
IS - 1
M3 - Article
SP - 244
EP - 250
SN - 09254005
AB - Abstract: Electrochemical glucose biosensor based on conducting microcells was constructed by imprisoning the enzymes in the cell arrays on an electrode. This kind of enzyme confinement showed a new way of construction of electrochemical biosensor without allowing modification of enzyme itself. The microtubular array was fabricated through electrochemical polymerization of EDOT into a template membrane attached on an ITO working electrode. The hollow tubules were loaded with glucose oxidase dispersed in aqueous buffer solution. To imprison the glucose oxidase into the cell, the opening of the tubule was sealed with PEDOT/PSS composite cap. The reinforcing electrochemical polymerization of PEDOT or poly(1,3-phenylenediamine) onto the sealing composite reduce the water solubility of the capping. The steady-state amperometric response to glucose was determined by detecting hydrogen peroxide generated by the action of the glucose oxidase. The effects of the applied potential, the gold treatment, the number of capping polymerization cycles, and the concentration of enzyme solution on the sensing properties of the electrode were examined. The calibration curve showed its linearity between 0 and 8mM and the response time was 20s. The sensor could retain good selectivity against interfering substances by capping the opening with electrochemically prepared non-conducting poly(1,3-phenylenediamine) layer. In summary, a glucose sensor which shows good selectivity and sensitivity was achieved by this enzyme-imprisonment procedure. This procedure has a wide applicability by just changing the enzyme to be loaded. [Copyright &y& Elsevier]
AB - Copyright of Sensors & Actuators B: Chemical is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUCOSE
KW - DETECTORS
KW - MICROTUBULES
KW - ELECTRODES
KW - Capping
KW - Enzyme
KW - Glucose biosensor
KW - Imprisonment
KW - Microtubule
N1 - Accession Number: 33136302; Park, Jongseo 1 Kim, Hong Kyu 2 Son, Yongkeun 3; Email Address: ykson@skku.edu; Affiliation: 1: Korea Food and Drug Administration, 158-050 Seoul, Republic of Korea 2: DC Chemical Co. LTD., Sungnam 462-120, Republic of Korea 3: Department of Chemistry and Advanced Materials and Process Research Center of IT(RIC), Sungkyunkwan University, 440-746 Suwon, Republic of Korea; Source Info: Jul2008, Vol. 133 Issue 1, p244; Subject Term: GLUCOSE; Subject Term: DETECTORS; Subject Term: MICROTUBULES; Subject Term: ELECTRODES; Author-Supplied Keyword: Capping; Author-Supplied Keyword: Enzyme; Author-Supplied Keyword: Glucose biosensor; Author-Supplied Keyword: Imprisonment; Author-Supplied Keyword: Microtubule; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.snb.2008.02.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hnizdo, Vladimir
AU - Tan, Jun
AU - Killian, Benjamin J.
AU - Gilson, Michael K.
T1 - Efficient calculation of configurational entropy from molecular simulations by combining the mutual-information expansion and nearest-neighbor methods.
JO - Journal of Computational Chemistry
JF - Journal of Computational Chemistry
Y1 - 2008/07/30/
VL - 29
IS - 10
M3 - Article
SP - 1605
EP - 1614
SN - 01928651
AB - Changes in the configurational entropies of molecules make important contributions to the free energies of reaction for processes such as protein-folding, noncovalent association, and conformational change. However, obtaining entropy from molecular simulations represents a long-standing computational challenge. Here, two recently introduced approaches, the nearest-neighbor (NN) method and the mutual-information expansion (MIE), are combined to furnish an efficient and accurate method of extracting the configurational entropy from a molecular simulation to a given order of correlations among the internal degrees of freedom. The resulting method takes advantage of the strengths of each approach. The NN method is entirely nonparametric (i.e., it makes no assumptions about the underlying probability distribution), its estimates are asymptotically unbiased and consistent, and it makes optimum use of a limited number of available data samples. The MIE, a systematic expansion of entropy in mutual information terms of increasing order, provides a well-characterized approximation for lowering the dimensionality of the numerical problem of calculating the entropy of a high-dimensional system. The combination of these two methods enables obtaining well-converged estimations of the configurational entropy that capture many-body correlations of higher order than is possible with the simple histogramming that was used in the MIE method originally. The combined method is tested here on two simple systems: an idealized system represented by an analytical distribution of six circular variables, where the full joint entropy and all the MIE terms are exactly known, and the R,S stereoisomer of tartaric acid, a molecule with seven internal-rotation degrees of freedom for which the full entropy of internal rotation has been already estimated by the NN method. For these two systems, all the expansion terms of the full MIE of the entropy are estimated by the NN method and, for comparison, the MIE approximations up to third order are also estimated by simple histogramming. The results indicate that the truncation of the MIE at the two-body level can be an accurate, computationally nondemanding approximation to the configurational entropy of anharmonic internal degrees of freedom. If needed, higher-order correlations can be estimated reliably by the NN method without excessive demands on the molecular-simulation sample size and computing time. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Computational Chemistry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTROPY
KW - MOLECULAR structure
KW - MOLECULES
KW - CONFORMATIONAL analysis
KW - SIMULATION methods & models
KW - configurational entropy
KW - dimension reduction
KW - many-body correlations
KW - molecular simulations
KW - mutual information
KW - nearest neighbor
N1 - Accession Number: 32461140; Hnizdo, Vladimir 1; Email Address: vhnizdo@cdc.gov Tan, Jun 2 Killian, Benjamin J. 3 Gilson, Michael K. 3; Email Address: gilson@umbi.umd.edu; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2: Department of Statistics, West Virginia University, Morgantown, West Virginia 26506 3: Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850; Source Info: 2008, Vol. 29 Issue 10, p1605; Subject Term: ENTROPY; Subject Term: MOLECULAR structure; Subject Term: MOLECULES; Subject Term: CONFORMATIONAL analysis; Subject Term: SIMULATION methods & models; Author-Supplied Keyword: configurational entropy; Author-Supplied Keyword: dimension reduction; Author-Supplied Keyword: many-body correlations; Author-Supplied Keyword: molecular simulations; Author-Supplied Keyword: mutual information; Author-Supplied Keyword: nearest neighbor; Number of Pages: 10p; Illustrations: 5 Charts, 5 Graphs; Document Type: Article
L3 - 10.1002/jcc.20919
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - John P. Cronin
AU - Anoop Agrawal
AU - Lori Adams
AU - Juan C. L. Tonazzi
AU - Michael J. Brisson
AU - Kenneth T. White
AU - David Marlow
AU - Kevin Ashley
T1 - Interlaboratory evaluation of an extraction and fluorescence method for the determination of trace beryllium in soils.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/07/30/
VL - 10
IS - 8
M3 - Article
SP - 955
EP - 960
SN - 14640325
AB - Analytical methods for the determination of trace beryllium in soils are needed so that anthropogenic sources of this element can be distinguished from native (background) levels of beryllium. In this work, a collaborative interlaboratory evaluation of a new extraction and fluorescence-based procedure for determining beryllium in soil samples was carried out to fulfil method validation requirements for ASTM International voluntary consensus standard test methods. A Canadian reference material, CCRMP Till-1 soil, with a background beryllium concentration of 2.4 μg g−1, was selected for study. This certified reference material (CRM) was spiked and homogenized with varying levels of beryllium oxide in order to give batches of material with beryllium concentrations of 4.36 ± 0.69, 11.5 ± 0.7, 124 ± 7 and 246 ± 16 μg g−1 (± values are standard deviations). In the interlaboratory study (ILS), which was carried out in accordance with an applicable ASTM International standard practice (ASTM E691), samples of these spiked soils were subjected to extraction in dilute ammonium bifluoride at ∼90 °C for 40 h. Fluorescence measurement of the extracted beryllium was carried out via detection using the high quantum yield fluorophore, hydroxybenzoquinoline sulfonate (HBQS). Interlaboratory precision estimates from six participating laboratories ranged from 0.048 to 0.103 (relative standard deviations) for the five different beryllium concentrations. Pooled bias estimates resulting from this ILS were between −0.049 and 0.177 for the various beryllium levels. These figures of merit support promulgation of the analytical procedure as an ASTM International standard test method. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Trace elements
KW - Anthropogenic soils
KW - Alkaline earth metals
KW - Fluorescence
KW - Beryllium oxide
N1 - Accession Number: 33396049; John P. Cronin 1; Anoop Agrawal 1; Lori Adams 1; Juan C. L. Tonazzi 1; Michael J. Brisson 2; Kenneth T. White 3; David Marlow 4; Kevin Ashley 4; Affiliations: 1: Berylliant, Inc4541 E. Fort Lowell Road Tucson USA; 2: Washington Savannah River CompanySavannah River Site 707-F Aiken USA; 3: Consultive Services4428 Ironwood Drive Virginia Beach USA; 4: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health4676 Columbia Parkway M.S. R-7 Cincinnati, OH USA KAshley@cdc.gov; Issue Info: Jul2008, Vol. 10 Issue 8, p955; Thesaurus Term: Beryllium; Thesaurus Term: Trace elements; Thesaurus Term: Anthropogenic soils; Thesaurus Term: Alkaline earth metals; Subject Term: Fluorescence; Subject Term: Beryllium oxide; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105549611
T1 - A Bayesian hierarchical model for the estimation of two incomplete surveillance data sets.
AU - Buenconsejo J
AU - Fish D
AU - Childs JE
AU - Holford TR
Y1 - 2008/07/30/
N1 - Accession Number: 105549611. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. NLM UID: 8215016.
KW - Data Analysis, Statistical
KW - Population -- Methods
KW - Probability
KW - Cluster Analysis
KW - Epidemiological Research
KW - Models, Statistical
KW - Rocky Mountain Spotted Fever -- Epidemiology
KW - Systems Analysis
KW - Human
SP - 3269
EP - 3285
JO - Statistics in Medicine
JF - Statistics in Medicine
JA - STAT MED
VL - 27
IS - 17
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
SN - 0277-6715
AD - Center for Drugs, Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Bldg. 22, Rm. 3241, Silver Spring, MD 20993-0002, USA. Joan.Buenconsejo@fda.hhs.gov
U2 - PMID: 18314934.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dayan-Kenigsberg, Jacqueline
AU - Bertocchi, Agnès
AU - Garber, Eric A.E.
T1 - Rapid detection of ricin in cosmetics and elimination of artifacts associated with wheat lectin
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
Y1 - 2008/07/31/
VL - 336
IS - 2
M3 - Article
SP - 251
EP - 254
SN - 00221759
AB - Abstract: Ricin can be detected in cosmetics at 0.005 µg/mL in the analytical sample using lateral flow devices (LFDs). Wheat germ, an ingredient used in skin care products is also a potential source of wheat lectin. False positives were observed when wheat lectin was added to LFDs from two manufacturers, irrespective of whether the LFD was specific for ricin, Staphylococcus enterotoxin B (SEB), or botulinum toxin. In contrast, pea and peanut lectins did not cause false positives. Substitution of the buffer supplied with the LFDs with a buffer containing 2.5% non-fat milk powder eliminated the occurrence of false positives. This substitution increased the LOD to 0.01 µg/mL ricin, which is an acceptable level for screening cosmetics for contamination by ricin. [Copyright &y& Elsevier]
AB - Copyright of Journal of Immunological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RICIN
KW - COSMETICS
KW - LECTINS
KW - TOXINS
KW - Cosmetics
KW - Detection
KW - Lateral flow devices (LFDs)
KW - Lectin
KW - Ricin
N1 - Accession Number: 32983911; Dayan-Kenigsberg, Jacqueline 1 Bertocchi, Agnès 1 Garber, Eric A.E. 2; Email Address: Eric.Garber@fda.hhs.gov; Affiliation: 1: Unité Biotechnologie, Biochimie des Protéines et Macromolécules, Agence Française de Sécurité Sanitaire des Produits de Santé, 143 boulevard Anatole France, 93285 Saint Denis Cedex, France 2: Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-716, 5100 Paint Branch Pkwy., College Park, MD, 20740, USA; Source Info: Jul2008, Vol. 336 Issue 2, p251; Subject Term: RICIN; Subject Term: COSMETICS; Subject Term: LECTINS; Subject Term: TOXINS; Author-Supplied Keyword: Cosmetics; Author-Supplied Keyword: Detection; Author-Supplied Keyword: Lateral flow devices (LFDs); Author-Supplied Keyword: Lectin; Author-Supplied Keyword: Ricin; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jim.2008.05.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32983911&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chung-Bridges, Katherine
AU - Muntaner, Caries
AU - Fleming, Lora E.
AU - Lee, David J.
AU - Arheart, Kristopher L.
AU - LeBlanc, William G.
AU - Christ, Sharon L.
AU - McCollister, Kathryn E.
AU - Caban, Aiberto J.
AU - Daviia, Eveiyn P.
T1 - Occupational Segregation as a Determinant of US Worker Health.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/08//
VL - 51
IS - 8
M3 - Article
SP - 555
EP - 567
SN - 02713586
AB - The article presents a study which underscores occupational segregation as a determinant of health of workers in the United States. As a background, it is stated that racial segregation offers a possible mechanism to relate occupations with untoward health outcomes. In this research, an African-American segregation index was computed of US worker groups from the nationally representative pooled 1986-1994 National Health Interview Survey. The results showed that there were positive connections between employment in segregated occupations and poor worker health, and that occupational segregation negatively affects all workers. Ranking and logistic regression analyses were used in this study.
KW - Industrial hygiene
KW - Occupations & race
KW - Occupational segregation
KW - Discrimination in employment
KW - Race discrimination
KW - Quality of work life
KW - Work environment
KW - Surveys
KW - Logistic regression analysis
KW - United States
KW - African-American workers
KW - health disparities
KW - occupational segregation
KW - worker health
N1 - Accession Number: 33412109; Chung-Bridges, Katherine 1,2; Muntaner, Caries 3,4; Fleming, Lora E. 1; Email Address: Ifleming@med.miami.edu; Lee, David J. 1; Arheart, Kristopher L. 1; LeBlanc, William G. 1; Christ, Sharon L. 5; McCollister, Kathryn E. 1; Caban, Aiberto J. 1; Daviia, Eveiyn P. 1; Affiliations: 1: Department of Epidemiology & Public Health, University of Miami, Leonard M. Miller School of Medicine, Miami Florida; 2: Department of Family Medicine, University of Miami, Leonard M. Miller School of Medicine, Miami, Florida; 3: Department of Behavioral and Community Health, University of Maryland, College Park, Maryland; 4: Faculty of Nursing, Department of Psychiatry, Center for addictions and Mental Health, Institute for Work and Health, University of Toronto, Toronto, Canada; 5: Department of Sociology, Odum Institute for Research in Social Science, University of North Carolina, Chapel Hill, North Carolina Contract grant sponsor: The National Institute for Occupational Safety and Health (NIOSH); Issue Info: Aug2008, Vol. 51 Issue 8, p555; Thesaurus Term: Industrial hygiene; Subject Term: Occupations & race; Subject Term: Occupational segregation; Subject Term: Discrimination in employment; Subject Term: Race discrimination; Subject Term: Quality of work life; Subject Term: Work environment; Subject Term: Surveys; Subject Term: Logistic regression analysis; Subject: United States; Author-Supplied Keyword: African-American workers; Author-Supplied Keyword: health disparities; Author-Supplied Keyword: occupational segregation; Author-Supplied Keyword: worker health; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1002/ajim.20599
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mazurek, Jacek M.
AU - Attfield, Michael D.
T1 - Silicosis Mortality Among Young Adults in the United States, 1968-2004.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/08//
VL - 51
IS - 8
M3 - Article
SP - 568
EP - 578
SN - 02713586
AB - The article presents a study which underscores silicosis mortality among young adults in the United States from 1968-2004. This study targets to describe silicosis deaths in young adults in the United States during the mentioned period, and that the National Center for Health Statistics multiple cause-of-death records were analyzed in this research. It is identified that occupations in construction and manufacturing industries were related with significantly high mortality ratios for young silicosis deaths.
KW - DISEASES
KW - Construction industry
KW - Silicosis
KW - Lungs -- Dust diseases
KW - Silicotics
KW - Young adults
KW - Death
KW - Manufacturing industries
KW - United States
KW - mortality
KW - occupational health
KW - silicosis
KW - surveillance
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 33412110; Mazurek, Jacek M. 1; Email Address: acq8@cdc.gov; Attfield, Michael D. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Aug2008, Vol. 51 Issue 8, p568; Thesaurus Term: DISEASES; Thesaurus Term: Construction industry; Subject Term: Silicosis; Subject Term: Lungs -- Dust diseases; Subject Term: Silicotics; Subject Term: Young adults; Subject Term: Death; Subject Term: Manufacturing industries; Subject: United States; Author-Supplied Keyword: mortality; Author-Supplied Keyword: occupational health; Author-Supplied Keyword: silicosis; Author-Supplied Keyword: surveillance ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 236110 Residential building construction; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1002/ajim.20597
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yanyan Jiang
AU - Ke Wen
AU - Xueping Zhou
AU - Schwegler-Berry, Diane
AU - Castranova, Vince
AU - Pingnian He
T1 - Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels.
JO - American Journal of Physiology: Heart & Circulatory Physiology
JF - American Journal of Physiology: Heart & Circulatory Physiology
Y1 - 2008/08//
VL - 64
IS - 2
M3 - Article
SP - H898
EP - H906
SN - 03636135
AB - Combining single-vessel perfusion technique with confocal microscopy, this study presents a new approach that allows three-dimensional visualization and quan- tification of endothelial gaps under experimental conditions identical to those used to measure permeability coefficients, endothelial calcium concentration, and nitric oxide production in individually perfused intact microvessels. This approach provides an efficient means for defining the transport pathways and cellular mechanisms of increased microvascular permeability during inflammation. Platelet- activating factor (PAF) was used to increase the permeability of individually perfused rat mesenteric venules. Fluorescent micro- spheres (FM5, 100 nm) were used as leakage markers, and confocal images were acquired at successive focal planes through the perfused microvessel. Perfusion of FMs under control conditions produced a thin, uniform layer of FMs in the vessel lumen, but in PAF-stimulated microvessels significant amounts of FMs accumulated at endothelial junctions. Reconstructed confocal images three-dimensionally delineated the temporal and spatial development of endothelial gaps in PAF-stimulated microvessels. The FM accumulation, quantified as the total fluorescence intensity per square micrometer of vessel wall, was 8.4 ± 1.8 times the control value within 10 mm of PAF perfusion and declined to 5.0 ± 0.6 and 1.4 ± 0.2 times the control value when FMs were applied 30 and 60 mm after PAF perfusion. The changes in the magnitude of FM accumulation closely correlated with the time course of PAF-induced increases in hydraulic conductivity (L1,), indicating that the opening and closing of endothelial gaps contributed to the transient increase in L4, in PAF-stimulated microvessels. Elec- tron microscopic evaluations confirmed PAF-induced gap formation and FM accumulation at endothelial clefts. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Heart & Circulatory Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIQUIDS
KW - OSMOSIS
KW - PERMEABILITY
KW - SOLIDS
KW - CONFOCAL microscopy
KW - confocal microscopy
KW - endothelial gap formation
KW - fluorescent microspheres
KW - hydraulic conductivity
KW - microvessel permeability
N1 - Accession Number: 34232654; Yanyan Jiang 1 Ke Wen 1,2 Xueping Zhou 1 Schwegler-Berry, Diane 3 Castranova, Vince 3 Pingnian He 1; Email Address: phe@hsc.wvu.edu; Affiliation: 1: Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 2: Department of Pharmacology, Tianjin Medical University, Tianjin, China 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Source Info: Aug2008, Vol. 64 Issue 2, pH898; Subject Term: LIQUIDS; Subject Term: OSMOSIS; Subject Term: PERMEABILITY; Subject Term: SOLIDS; Subject Term: CONFOCAL microscopy; Author-Supplied Keyword: confocal microscopy; Author-Supplied Keyword: endothelial gap formation; Author-Supplied Keyword: fluorescent microspheres; Author-Supplied Keyword: hydraulic conductivity; Author-Supplied Keyword: microvessel permeability; Number of Pages: 9p; Illustrations: 8 Graphs; Document Type: Article
L3 - 10.1152/ajpheart.00309.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kauffman, John F.
AU - Gilliam, Sean J.
AU - Martin, R. Scott
T1 - Chemical Imaging of Pharmaceutical Materials: Fabrication of Micropatterned Resolution Targets.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2008/08//8/1/2008
VL - 80
IS - 15
M3 - Article
SP - 5706
EP - 5712
SN - 00032700
AB - Resolution targets composed of thick poly(ethylene glycol) (PEG) lines on silicon substrates have been fabricated using the method of micromolding in capillaries (MiMIC). Patterns of three parallel lines with equal width and spacing have been prepared, with widths between 5 and 25 μm. Raman chemical images of the PEG-on-silicon devices as well as the metal-on-glass masks used to prepare the devices were measured. The Raman images were used to determine the impulse response of the instrument by comparing the measured images to model functions prepared by convolution of a test impulse function with the object functions of the devices. Impulse widths for PEG-on-silicon targets were approximately two times greater than impulse widths for metal-on-glass targets. The results provide a quantitative measure of the influence of light-matter interactions on the spatial resolution achievable with chemical imaging instruments. This work shows that microfluidic channels can be used to produce robust patterns of PEG on silicon, and these patterns are realistic resolution targets for spectroscopic chemical imaging of pharmaceutical materials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGING systems in chemistry
KW - RAMAN spectroscopy
KW - IMPULSE response
KW - SILICON -- Spectra
KW - RAMAN effect
KW - MASKS (Electronics)
KW - MICROFLUIDICS
N1 - Accession Number: 34121095; Kauffman, John F. 1; Email Address: John.Kauffman@fda.hhs.gov Gilliam, Sean J. 1,2 Martin, R. Scott 3; Affiliation: 1: Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101. 2: Sean Gilliam, Kaiser Optical Systems Inc., 371 Parkland Plaza, Ann Arbor, MI 48103. 3: Department of Chemistry, Saint Louis University, St. Louis, Missouri 63103.; Source Info: 8/1/2008, Vol. 80 Issue 15, p5706; Subject Term: IMAGING systems in chemistry; Subject Term: RAMAN spectroscopy; Subject Term: IMPULSE response; Subject Term: SILICON -- Spectra; Subject Term: RAMAN effect; Subject Term: MASKS (Electronics); Subject Term: MICROFLUIDICS; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paul W. Buehler
AU - Florence Vallelian
AU - Malgorzata G. Mikolajczyk
AU - Gabriele Schoedon
AU - Thomas Schweizer
AU - Abdu I. Alayash
AU - Dominik J. Schaer
T1 - Structural Stabilization in Tetrameric or Polymeric Hemoglobin Determines Its Interaction with Endogenous Antioxidant Scavenger Pathways.
JO - Antioxidants & Redox Signaling
JF - Antioxidants & Redox Signaling
Y1 - 2008/08//
VL - 10
IS - 8
M3 - Article
SP - 1449
EP - 1462
SN - 15230864
AB - Hemoglobin (Hb) released into the circulation during hemolysis and chemically modified Hb proposed for use as oxygen therapeutics exert toxic effects that are partially attributable to heme's oxidant activity. Native extracellular Hb is scavenged by haptoglobin (Hp) after αβ-subunit dimerization. In the absence of Hp, monocytemacrophage cell-surface CD163 binds and clears Hb. We evaluated several chemically modified Hbs to establish the role of chemical cross-linking patterns and molecular sizes on binding and clearance by each pathway. We found that Hbs possessing β-globin cross-linking, irrespective of polymerization, demonstrate increased Hp affinity compared with α-globin–stabilized Hbs. These data suggest that Hb α-subunit accessibility is critical for Hp binding in the absence of dimerization. β-Globin chain cross-linked tetramerspolymers displayed strong polyvalent Hp binding with increased viscosity and formation of visible gel matrices. Modified Hb interaction with CD163 and cellular uptake demonstrated an inverse relation with molecular size, irrespective of αand βcross-linking. These findings were confirmed by HO-1 induction and intracellular ferritin accumulation in CD163-expressing HEK293 cells. Based on these results, a rational and systematic approach to HBOC design may be used to optimize interaction with endogenous Hb clearance and detoxification pathways. [ABSTRACT FROM AUTHOR]
AB - Copyright of Antioxidants & Redox Signaling is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - CROSSLINKING (Polymerization)
KW - CARRIER proteins
KW - HAPTOGLOBINS
N1 - Accession Number: 33049868; Paul W. Buehler 1 Florence Vallelian 2 Malgorzata G. Mikolajczyk 1 Gabriele Schoedon 2 Thomas Schweizer 3 Abdu I. Alayash 1 Dominik J. Schaer 2; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Rockville, Maryland. 2: Medical Clinic Research Unit, University of Zurich, ETH Zurich, Switzerland. 3: Polymer Physics, Department of Materials, ETH Zurich, Switzerland.; Source Info: Aug2008, Vol. 10 Issue 8, p1449; Subject Term: HEMOGLOBIN; Subject Term: CROSSLINKING (Polymerization); Subject Term: CARRIER proteins; Subject Term: HAPTOGLOBINS; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105809419
T1 - High levels of physical inactivity and sedentary behaviors among US immigrant children and adolescents.
AU - Singh GK
AU - Yu SM
AU - Siahpush M
AU - Kogan MD
Y1 - 2008/08//
N1 - Accession Number: 105809419. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 9422751.
KW - Adolescent Behavior
KW - Child Behavior
KW - Emigration and Immigration
KW - Ethnic Groups -- Statistics and Numerical Data
KW - Life Style
KW - Adolescence
KW - Child
KW - Cross Sectional Studies
KW - Demography
KW - Female
KW - Incidence
KW - Leisure Activities
KW - Logistic Regression
KW - Male
KW - Multivariate Analysis
KW - Physical Fitness
KW - Risk Assessment
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 756
EP - 763
JO - Archives of Pediatrics & Adolescent Medicine
JF - Archives of Pediatrics & Adolescent Medicine
JA - ARCH PEDIATR ADOLESC MED
VL - 162
IS - 8
CY - Chicago, Illinois
PB - American Medical Association
SN - 1072-4710
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Ln, Room 18-41, Rockville, MD 20857, USA. gsingh@hrsa.gov
U2 - PMID: 18678808.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Krieg Jr, Edward F.
AU - Chrislip, David W.
AU - Brightwell, W. Stephen
T1 - A meta-analysis of studies investigating the effects of lead exposure on nerve conduction.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2008/08//
VL - 82
IS - 8
M3 - Article
SP - 531
EP - 542
SN - 03405761
AB - Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log10 blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0 μg/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAL conduction
KW - META-analysis
KW - NEUROLOGY -- Research
KW - LEAD -- Physiological effect
KW - LEAD -- Toxicology
KW - PERONEAL nerve
KW - NEUROPATHY
KW - Blood lead
KW - Nerve conduction
N1 - Accession Number: 33436804; Krieg Jr, Edward F. 1; Email Address: erk3@cdc.gov Chrislip, David W. 2 Brightwell, W. Stephen 2; Affiliation: 1: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, USA 2: Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH 45226, USA; Source Info: Aug2008, Vol. 82 Issue 8, p531; Subject Term: NEURAL conduction; Subject Term: META-analysis; Subject Term: NEUROLOGY -- Research; Subject Term: LEAD -- Physiological effect; Subject Term: LEAD -- Toxicology; Subject Term: PERONEAL nerve; Subject Term: NEUROPATHY; Author-Supplied Keyword: Blood lead; Author-Supplied Keyword: Nerve conduction; Number of Pages: 12p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00204-008-0292-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bass, A. S.
AU - Darpo, B.
AU - Breidenbach, A.
AU - Bruse, K.
AU - Feldman, H. S.
AU - Garnes, D.
AU - Hammond, T.
AU - Haverkamp, W.
AU - January, C.
AU - Koerner, J.
AU - Lawrence, C.
AU - Leishman, D.
AU - Roden, D.
AU - Valentin, J. P.
AU - Vos, M. A.
AU - Zhou, Y. -Y.
AU - Karluss, T.
AU - Sager, P.
T1 - International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes.
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
Y1 - 2008/08//
VL - 154
IS - 7
M3 - Article
SP - 1491
EP - 1501
PB - Wiley-Blackwell
SN - 00071188
AB - Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients. Present methodologies for assessing drug-induced torsades de pointes (TdP) are woefully inadequate in terms of their specificity to select pharmaceutical agents, which are human arrhythmia toxicants. Thus, the critical challenge in the pharmaceutical industry today is to identify experimental models, composite strategies, or biomarkers of cardiac risk that can distinguish a drug, which prolongs cardiac ventricular repolarization, but is not proarrhythmic, from one that prolongs the QT interval and leads to TdP. To that end, the HESI Proarrhythmia Models Project Committee recognized that there was little practical understanding of the relationship between drug effects on cardiac ventricular repolarization and the rare clinical event of TdP. It was on that basis that a workshop was convened in Virginia, USA at which four topics were introduced by invited subject matter experts in the following fields: Molecular and Cellular Biology Underlying TdP, Dynamics of Periodicity, Models of TdP Proarrhythmia, and Key Considerations for Demonstrating Utility of Pre-Clinical Models. Contained in this special issue of the British Journal of Pharmacology are reports from each of the presenters that set out the background and key areas of discussion in each of these topic areas. Based on this information, the scientific community is encouraged to consider the ideas advanced in this workshop and to contribute to these important areas of investigations over the next several years.British Journal of Pharmacology (2008) 154, 1491–1501; doi:10.1038/bjp.2008.279 [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ARRHYTHMIA
KW - HEART diseases
KW - DRUGS -- Physiological effect
KW - LONG QT syndrome
KW - ELECTROCARDIOGRAPHY
KW - PHARMACOLOGY
KW - arrhythmia
KW - cardiac toxicity
KW - electrocardiogram
KW - hERG
KW - I[subKr]
KW - long QT syndrome
KW - QT prolongation
KW - safety pharmacology
KW - torsades de pointes
KW - ventricular repolarization
N1 - Accession Number: 33326913; Bass, A. S. 1; Email Address: alan.bass@spcorp.com Darpo, B. 2 Breidenbach, A. 3 Bruse, K. 4 Feldman, H. S. 5 Garnes, D. 6 Hammond, T. 7 Haverkamp, W. 8 January, C. 9 Koerner, J. 10 Lawrence, C. 7 Leishman, D. 11 Roden, D. 12 Valentin, J. P. 7 Vos, M. A. 13 Zhou, Y. -Y. 14 Karluss, T. 15 Sager, P. 16; Affiliation: 1: Drug Safety and Metabolism, Schering-Plough Research Institute, Kenilworth, NJ, USA 2: Pharmaceutical Consultant, Lidingo, Sweden 3: Pharmaceuticals Division, Safety Pharmacology, F Hoffmann - La Roche Ltd, Basel, Switzerland 4: Safety Pharmacology, Covance Laboratories Inc., Madison, Wisconsin, USA 5: Safety Pharmacology, Wyeth Research, Chazy, NY, USA 6: Animal Welfare Compliance, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA 7: AstraZeneca R&D Alderley Park, Safety Assessment UK, Mereside, Macclesfield, Cheshire, England 8: Medizinische Klinik m. S Kardiologie, Campus Virchow-Klinikum, Charité—Universitätsmedizin Berlin, Berlin, Germany 9: Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA 10: Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA 11: Lilly Research Laboratories, Greenfield Laboratories, Greenfield, IN, USA 12: School of Medicine, Vanderbilt University, Nashville, TN, USA 13: University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands 14: Investigational and Regulatory Safety Pharmacology, Schering Plough Research Institute, Lafayette, NJ, USA 15: International Life Sciences Institute (Health and Environmental Sciences Institute), Washington, DC, USA 16: CV Research, AstraZeneca LP, Wilmington, DE, USA; Source Info: Aug2008, Vol. 154 Issue 7, p1491; Subject Term: ARRHYTHMIA; Subject Term: HEART diseases; Subject Term: DRUGS -- Physiological effect; Subject Term: LONG QT syndrome; Subject Term: ELECTROCARDIOGRAPHY; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: arrhythmia; Author-Supplied Keyword: cardiac toxicity; Author-Supplied Keyword: electrocardiogram; Author-Supplied Keyword: hERG; Author-Supplied Keyword: I[subKr]; Author-Supplied Keyword: long QT syndrome; Author-Supplied Keyword: QT prolongation; Author-Supplied Keyword: safety pharmacology; Author-Supplied Keyword: torsades de pointes; Author-Supplied Keyword: ventricular repolarization; Number of Pages: 11p; Document Type: Article
L3 - 10.1038/bjp.2008.279
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Variants of DNA Repair Genes and the Risk of Biliary Tract Cancers and Stones: A Population-Based Study in China.
AU - Mingdong Zhang
AU - Wen-Yi Huang
AU - Andreotti, Gabriella
AU - Yu-Tang Gao
AU - Rashid, Asif
AU - Jinbo Chen
AU - Sakoda, Lori C.
AU - Ming-Chang Shen
AU - Bing-Sheng Wang
AU - Chanock, Stephen
AU - Hsing, Ann W.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2008/08//
VL - 17
IS - 8
SP - 2123
EP - 2127
SN - 10559965
N1 - Accession Number: 34450831; Author: Mingdong Zhang: 1,2 Author: Wen-Yi Huang: 2 Author: Andreotti, Gabriella: 2 Author: Yu-Tang Gao: 3 Author: Rashid, Asif: 4 Author: Jinbo Chen: 5 Author: Sakoda, Lori C.: 6 Author: Ming-Chang Shen: 7 Author: Bing-Sheng Wang: 8 Author: Chanock, Stephen: 2,9 Author: Hsing, Ann W.: 2 email: hsinga@mail.nih.gov. ; Author Affiliation: 1 Food and Drug Administration, Rockville, Maryland: 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland: 3 Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China: 4 Department of Pathology, M. D. Anderson Cancer Center, Houston, Texas: 5 Department of Epidemiology and Biostatistics, University of Pennsylvania, Pennsylvania: 6 Department of Epidemiology, University of Washington, Washington: 7 Shanghai Tumor Hospital, Fudan University, Shanghai, China: 8 Zhongshan Hospital, Fudan University, Shanghai, China: 9 Core Genotyping Facility, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland; No. of Pages: 5; Language: English; Publication Type: Article; Update Code: 20080924
N2 - The article reports on results of a population-based study in China of variants of DNA repair genes and the risk of biliary tract cancers and stones. A description of the experimental set-up and measurement method is provided. The study concluded that MGMT gene variants mat alter susceptibility to biliary tract cancer, particularly gallbladder cancer.
KW - *CANCER
KW - DNA repair
KW - BILIARY tract
KW - GALLBLADDER
KW - CANCER genetics
KW - CHINA
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Soldin, Offie P.
AU - Dahlin, Julia R.B.
AU - Gresham, Eric G.
AU - King, Julia
AU - Soldin, Steven J.
T1 - IMMULITE® 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone
JO - Clinical Biochemistry
JF - Clinical Biochemistry
Y1 - 2008/08//
VL - 41
IS - 12
M3 - Article
SP - 937
EP - 942
SN - 00099120
AB - Abstract: Objectives: To determine age and sex-specific pediatric reference intervals for serum alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and parathyroid hormone. Design and methods: The study was conducted at both Children''s National Medical Center and Georgetown University, Washington D.C. Results for the above analytes were obtained from the Children''s National Medical Center laboratory information system over the period of 1/5/2001–3/8/2007.Patient results using the IMMULITE 2000® were accessed and used to establish reference intervals for the analytes studied. All patient identifiers were removed except age and sex. Analysis of the data was performed at Georgetown University in the Bioanalytical Core Laboratory. The data was analyzed using the Hoffmann approach, and was computer adapted. The number of patient samples studied varied with each analyte and were: Alpha fetoprotein (557), homocysteine (924), insulin-like growth factor-1 (1352), insulin-like growth factor binding protein-3 (711), insulin (3239), C-peptide (267), immunoglobulin E (2691) and parathyroid hormone (513). Results and conclusions: This study provides pediatric reference intervals for the eight analytes for children from birth to 18 years of age. All the analytes exhibited at least some age dependence. Sex differences between early and late childhood and adolescence were also frequently found. [Copyright &y& Elsevier]
AB - Copyright of Clinical Biochemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALPHA fetoproteins
KW - HOMOCYSTEINE
KW - INSULIN
KW - IMMUNOGLOBULINS
KW - Alpha fetoprotein
KW - C-peptide
KW - Homocysteine
KW - Immunoglobulin E
KW - Insulin
KW - Insulin-like growth factor binding protein-3
KW - Insulin-like growth factor-I
KW - Parathyroid hormone
KW - Pediatric
KW - Reference intervals
N1 - Accession Number: 33345019; Soldin, Offie P. 1,2,3 Dahlin, Julia R.B. 4 Gresham, Eric G. 4 King, Julia 4 Soldin, Steven J. 2,4; Email Address: sjs44@georgetown.edu; Affiliation: 1: Department of Oncology, Physiology, Georgetown University Medical Center, USA 2: Bioanalytical Core Laboratory, Department of Medicine, Georgetown University Medical Center, USA 3: Center for Drug Evaluation and Research, US Food and Drug Administration For the Obstetric Pharmacology Research Network, Sponsored by National Institute of Child Health and Development, USA 4: Departments of Pediatrics and Pathology, The George Washington University and Department of Laboratory Medicine, Children’s National Medical Center, Washington D.C., USA; Source Info: Aug2008, Vol. 41 Issue 12, p937; Subject Term: ALPHA fetoproteins; Subject Term: HOMOCYSTEINE; Subject Term: INSULIN; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: Alpha fetoprotein; Author-Supplied Keyword: C-peptide; Author-Supplied Keyword: Homocysteine; Author-Supplied Keyword: Immunoglobulin E; Author-Supplied Keyword: Insulin; Author-Supplied Keyword: Insulin-like growth factor binding protein-3; Author-Supplied Keyword: Insulin-like growth factor-I; Author-Supplied Keyword: Parathyroid hormone; Author-Supplied Keyword: Pediatric; Author-Supplied Keyword: Reference intervals; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.clinbiochem.2008.04.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petruccio, Claudia
AU - Shaw, Kenna R. Mills
AU - Boughman, Joann
AU - Fernandez, Carlos
AU - Harlow, Ilana
AU - Kruesi, Margaret
AU - Kyler, Penny
AU - Lloyd-Puryear, Michele A.
AU - O'Leary, James
AU - Skillman, Amy
AU - Terry, Sharon
AU - McKain, Fredrika
T1 - Healthy Choices through Family History: A Community Approach to Family History Awareness.
JO - Community Genetics
JF - Community Genetics
Y1 - 2008/08//
VL - 11
IS - 6
M3 - Article
SP - 343
EP - 351
SN - 14222795
AB - Background: The importance of family health history data in health care is widely acknowledged. Few individuals report having collected this information from their own family. Methods: This project implemented a community-based approach to design and pilot a linguistically and culturally appropriate family health history collection toolkit for two minority populations in Harrisburg, Pa. Results: The toolkit relied on oral traditions and family stories as a way to successfully introduce genetics education and family health history to these populations. Participants not only found the tool engaging and culturally appropriate, they were also able to obtain information that they were likely to share with their physician. Conclusion: While limited in scope, this project provides a model to other communities for the design, pilot testing, and implementation of a community-based public health initiative regarding family health histories. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Community Genetics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FAMILIES -- Health
KW - MEDICAL history taking
KW - ORAL history
KW - HEALTH disparities
KW - PUBLIC health
KW - FAMILY history (Sociology)
KW - Cultural competency
KW - Family health history
KW - Family history
KW - Health disparities
KW - Linguistic competency
KW - Oral history
N1 - Accession Number: 33552013; Petruccio, Claudia 1; Email Address: petruccio@culturalpartnerships.org Shaw, Kenna R. Mills 2 Boughman, Joann 2 Fernandez, Carlos 1 Harlow, Ilana 3 Kruesi, Margaret 3 Kyler, Penny 4 Lloyd-Puryear, Michele A. 4 O'Leary, James 5 Skillman, Amy 1 Terry, Sharon 5 McKain, Fredrika 1; Affiliation: 1: Institute for Cultural Partnerships, Harrisburg, Pa. 2: American Society of Human Genetics, Bethesda, Md. 3: American Folklife Center, Washington, D.C. 4: Health Resources and Services Administration, Rockville, Md., USA 5: Genetic Alliance, Washington, D.C.; Source Info: 2008, Vol. 11 Issue 6, p343; Subject Term: FAMILIES -- Health; Subject Term: MEDICAL history taking; Subject Term: ORAL history; Subject Term: HEALTH disparities; Subject Term: PUBLIC health; Subject Term: FAMILY history (Sociology); Author-Supplied Keyword: Cultural competency; Author-Supplied Keyword: Family health history; Author-Supplied Keyword: Family history; Author-Supplied Keyword: Health disparities; Author-Supplied Keyword: Linguistic competency; Author-Supplied Keyword: Oral history; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1159/000133306
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chipinda, Itai
AU - Hettick, Justin M.
AU - Simoyi, Reuben H.
AU - Siegel, Paul D.
T1 - Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 2008/08//
VL - 59
IS - 2
M3 - Article
SP - 79
EP - 89
PB - Wiley-Blackwell
SN - 01051873
AB - Background: Zinc diethyldithiocarbamate (ZDEC) and its disulfide, tetraethylthiuram disulfide (TETD), are rubber accelerators and contact allergens that cross-react in some individuals. Objective: This study explored potential protein haptenation mechanisms of ZDEC and its oxidation products. Methods: ZDEC oxidation/reduction products and sites of protein binding were assessed using high-performance liquid chromatography and mass spectrometry. The murine local lymph node assay (LLNA) was employed to probe haptenation mechanisms of ZDEC by examining its allergenicity along with its oxidation products and through elimination of oxidation and chelation mechanisms by substituting cobalt for zinc [cobalt (II) dithiocarbamate, CoDEC]. Results: Oxidation of ZDEC by hypochlorous acid (bleach, HOCl), iodine, or hydrogen peroxide resulted in production of TETD, tetraethylthiocarbamoyl disulfide, and tetraethyldicarbamoyl disulfide (TEDCD). Albumin thiols reduced TETD with subsequent mixed disulfide formation/haptenation. ZDEC directly chelated the copper ion on the active site of the superoxide dismutase, whereas CoDEC did not bind to Cu proteins or form mixed disulfides with free thiols. ZDEC, sodium diethyldithiocarbamate, TEDCD, and TETD were all positive in the LLNA except CoDEC, which was non-allergenic. Conclusion: The thiol is the critical functional group in ZDEC’s allergenicity, and haptenation is predominantly through chelation of metalloproteins and formation of mixed disulfides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETHYLDITHIOCARBAMATE
KW - ZINC
KW - ALLERGENS
KW - DERMATOLOGY
KW - HIGH performance liquid chromatography
KW - MASS spectrometry
KW - OXIDATION
KW - allergenicity
KW - diethyldithiocarbamate
KW - haptenation
KW - local lymph node assay
KW - mechanism
KW - oxidation
KW - thiuram
N1 - Accession Number: 33334592; Chipinda, Itai 1; Email Address: ichipinda@cdc.gov Hettick, Justin M. 1 Simoyi, Reuben H. 2 Siegel, Paul D. 1; Affiliation: 1: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA 2: Department of Chemistry, Portland State University, Portland, OR 97201-0751, USA; Source Info: Aug2008, Vol. 59 Issue 2, p79; Subject Term: DIETHYLDITHIOCARBAMATE; Subject Term: ZINC; Subject Term: ALLERGENS; Subject Term: DERMATOLOGY; Subject Term: HIGH performance liquid chromatography; Subject Term: MASS spectrometry; Subject Term: OXIDATION; Author-Supplied Keyword: allergenicity; Author-Supplied Keyword: diethyldithiocarbamate; Author-Supplied Keyword: haptenation; Author-Supplied Keyword: local lymph node assay; Author-Supplied Keyword: mechanism; Author-Supplied Keyword: oxidation; Author-Supplied Keyword: thiuram; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 11p; Illustrations: 2 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0536.2008.01399.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33334592&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Swann, Patrick G
AU - Tolnay, Mate
AU - Muthukkumar, Subramanian
AU - Shapiro, Marjorie A
AU - Rellahan, Barbara L
AU - Clouse, Kathleen A
T1 - Considerations for the development of therapeutic monoclonal antibodies
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
Y1 - 2008/08//
VL - 20
IS - 4
M3 - Article
SP - 493
EP - 499
SN - 09527915
AB - An increasing number of Investigational New Drug (IND) applications for therapeutic monoclonal antibodies (mAbs) have been submitted to US FDA over the past several years. Monoclonal antibodies and related products are under development for a wide range of indications. In addition, the diversity of antibody-related products is increasing including IgG2/IgG4 subclasses and engineered Fc regions to enhance or reduce antibody effector functionality. Recent findings highlight the need to more fully characterize these products and their activity. Advances in product characterization tools, immunogenicity assessments, and other bioanalytical assays can be used to better understand product performance and facilitate development. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Immunology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MOLECULAR cloning
KW - MONOCLONAL antibodies
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 33630272; Swann, Patrick G 1; Email Address: patrick.swann@fda.hhs.gov Tolnay, Mate 1 Muthukkumar, Subramanian 1 Shapiro, Marjorie A 1 Rellahan, Barbara L 1 Clouse, Kathleen A 1; Affiliation: 1: Division of Monoclonal Antibodies, Center for Drugs Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Aug2008, Vol. 20 Issue 4, p493; Subject Term: IMMUNOGLOBULINS; Subject Term: MOLECULAR cloning; Subject Term: MONOCLONAL antibodies; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.coi.2008.05.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soju Chang
AU - Pool, Vitali
AU - O'Connell, Kathryn
AU - Polder, Jacquelyn A.
AU - Iskander, John
AU - Sweeney, Colleen
AU - Ball, Robert
AU - Braun, M. Miles
T1 - Preventable Mix-ups of Tuberculin and Vaccines.
JO - Drug Safety
JF - Drug Safety
Y1 - 2008/08//
VL - 31
IS - 11
M3 - Article
SP - 1027
EP - 1033
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Background: Errors involving the mix-up of tuberculin purified protein derivative (PPD) and vaccines leading to adverse reactions and unnecessary medical management have been reported previously. Objectives: To determine the frequency of PPD-vaccine mix-ups reported to the US Vaccine Adverse Event Reporting System (VAERS) and the Adverse Event Reporting System (AERS), characterize adverse events and clusters involving mix-ups and describe reported contributory factors. Methods: We reviewed AERS reports from 1969 to 2005 and VAERS reports from 1990 to 2005. We defined a mix-up error event as an incident in which a single patient or a cluster of patients inadvertently received vaccine instead of a PPD product or received a PPD product instead of vaccine. We defined a cluster as inadvertent administration of PPD or vaccine products to more than one patient in the same facility within 1 month. Results: Of 115 mix-up events identified, 101 involved inadvertent administration of vaccines instead of PPD. Product confusion involved PPD and multiple vaccines. The annual number of reported mix-ups increased from an average of one event per year in the early 1990s to an average of ten events per year in the early part of this decade. More than 240 adults and children were affected and the majority reported local injection site reactions. Four individuals were hospitalized (all recovered) after receiving the wrong products. Several patients were inappropriately started on tuberculosis prophylaxis as a result of a vaccine local reaction being interpreted as a positive tuberculin skin test. Reported potential contributory factors involved both system factors (e.g. similar packaging) and human errors (e.g. failure to read label before product administration). Conclusions: To prevent PPD-vaccine mix-ups, proper storage, handling and administration of vaccine and PPD products is necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUBERCULIN
KW - VACCINES
KW - DRUGS -- Side effects
KW - INJECTIONS
KW - TUBERCULOSIS
KW - PATIENTS
N1 - Accession Number: 37704949; Soju Chang 1; Email Address: sojuchang@hotmail.com Pool, Vitali 2 O'Connell, Kathryn 1 Polder, Jacquelyn A. 1 Iskander, John 2 Sweeney, Colleen 3 Ball, Robert 1 Braun, M. Miles 1; Affiliation: 1: Office of Biostatistics and Epidemiology, US Food and Drug Administration (FDA), Rockville, Maryland, USA 2: Immunization Safety Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA 3: Office of Vaccines Research and Review, Center for Biologies Evaluation and Research, US Food and Drug Administration (FDA), Rockville, Maryland, USA; Source Info: 2008, Vol. 31 Issue 11, p1027; Subject Term: TUBERCULIN; Subject Term: VACCINES; Subject Term: DRUGS -- Side effects; Subject Term: INJECTIONS; Subject Term: TUBERCULOSIS; Subject Term: PATIENTS; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, Kuei-Meng
AU - Ghantous, Hanan
AU - Birnkrant, Debra B.
T1 - Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/08//
VL - 46
IS - 8
M3 - Article
SP - 2606
EP - 2610
SN - 02786915
AB - Abstract: Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen®) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen®) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERBAL medicine
KW - DRUG delivery systems
KW - PHARMACOLOGY
KW - CLINICAL trials
KW - TOXICOLOGY
KW - Botanical
KW - Carcinogenicity
KW - Genotoxicity
KW - Herbal
KW - Regulatory toxicology
KW - Reproductive toxicity
N1 - Accession Number: 33345388; Wu, Kuei-Meng; Email Address: kueimeng.wu@fda.hhs.gov Ghantous, Hanan 1 Birnkrant, Debra B. 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States; Source Info: Aug2008, Vol. 46 Issue 8, p2606; Subject Term: HERBAL medicine; Subject Term: DRUG delivery systems; Subject Term: PHARMACOLOGY; Subject Term: CLINICAL trials; Subject Term: TOXICOLOGY; Author-Supplied Keyword: Botanical; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: Herbal; Author-Supplied Keyword: Regulatory toxicology; Author-Supplied Keyword: Reproductive toxicity; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.fct.2008.05.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Whittaker, Paul
AU - Clarke, Jane J.
AU - San, Richard H.C.
AU - Begley, Timothy H.
AU - Dunkel, Virginia C.
T1 - Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/08//
VL - 46
IS - 8
M3 - Article
SP - 2928
EP - 2933
SN - 02786915
AB - Abstract: Diacetyl (2,3-butanedione) is a yellowish liquid that is usually mixed with other ingredients to produce butter flavor or other flavors in a variety of food products. Inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Recent findings have shown irreversible obstructive lung disease among workers not only in the microwave popcorn industry, but also in flavoring manufacture, and in chemical synthesis of diacetyl, a predominant chemical for butter flavoring. It has been reported that perfluorochemicals utilized in food packaging are migrating into foods and may be sources of oral exposure. Relatively small quantities of perfluorochemicals are used in the manufacturing of paper or paperboard that is in direct contact with food to repel oil or grease and water. Because of recent concerns about perfluorochemicals such as those found on microwave popcorn bags (e.g. Lodyne P208E®) and diacetyl in foods, we evaluated both compounds for mutagenicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Lodyne P208E® was less toxic than diacetyl and did not induce a mutagenic response. Diacetyl induced a highly mutagenic response in the L5178Y mouse lymphoma mutation assay in the presence of human liver S9 for activation. The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIACETYL
KW - BUTTER -- Flavor & odor
KW - FLAVOR
KW - MICROWAVE food products industry
KW - POPCORN
KW - FOOD -- Packaging
KW - CHEMICALS -- Physiological effect
KW - 7,12-dimethylbenzanthracene ( DMBA )
KW - Diacetyl
KW - dimethyl sulfoxide ( DMSO )
KW - Flavoring and Extract Manufacturers Association ( FEMA )
KW - generally recognized as safe ( GRAS )
KW - Lodyne
KW - Mouse lymphoma
KW - Mutagenicity
KW - thymidine kinase ( TK )
KW - trifluorothymidine ( TFT )
KW - US Environmental Protection Agency ( EPA )
KW - US Food and Drug Administration ( FDA )
KW - US National Institute for Occupational Safety and Health ( NIOSH )
KW - US Occupational Safety and Health Administration ( OSHA )
N1 - Accession Number: 33345434; Whittaker, Paul 1; Email Address: paul.whittaker@fda.hhs.gov Clarke, Jane J. 2 San, Richard H.C. 3 Begley, Timothy H. 1 Dunkel, Virginia C. 4; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States 2: BioReliance, 14920 Broschart Road, Rockville, MD 20850, United States 3: Gaithersburg, MD, United States 4: Bethesda, MD, United States; Source Info: Aug2008, Vol. 46 Issue 8, p2928; Subject Term: DIACETYL; Subject Term: BUTTER -- Flavor & odor; Subject Term: FLAVOR; Subject Term: MICROWAVE food products industry; Subject Term: POPCORN; Subject Term: FOOD -- Packaging; Subject Term: CHEMICALS -- Physiological effect; Author-Supplied Keyword: 7,12-dimethylbenzanthracene ( DMBA ); Author-Supplied Keyword: Diacetyl; Author-Supplied Keyword: dimethyl sulfoxide ( DMSO ); Author-Supplied Keyword: Flavoring and Extract Manufacturers Association ( FEMA ); Author-Supplied Keyword: generally recognized as safe ( GRAS ); Author-Supplied Keyword: Lodyne; Author-Supplied Keyword: Mouse lymphoma; Author-Supplied Keyword: Mutagenicity; Author-Supplied Keyword: thymidine kinase ( TK ); Author-Supplied Keyword: trifluorothymidine ( TFT ); Author-Supplied Keyword: US Environmental Protection Agency ( EPA ); Author-Supplied Keyword: US Food and Drug Administration ( FDA ); Author-Supplied Keyword: US National Institute for Occupational Safety and Health ( NIOSH ); Author-Supplied Keyword: US Occupational Safety and Health Administration ( OSHA ); NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 424450 Confectionery Merchant Wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; NAICS/Industry Codes: 311919 Other Snack Food Manufacturing; NAICS/Industry Codes: 111150 Corn Farming; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fct.2008.06.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yourick, Jeffrey J.
AU - Sasik, Camille T.
AU - Bronaugh, Robert L.
T1 - In vitro dermal absorption and metabolism of D&C red no. 17 in human and porcine skin.
JO - International Journal of Cosmetic Science
JF - International Journal of Cosmetic Science
Y1 - 2008/08//
VL - 30
IS - 4
M3 - Article
SP - 310
EP - 311
PB - Wiley-Blackwell
SN - 01425463
AB - D&C red no. 17 is approved for use in externally applied drug and cosmetic applications, in amounts consistent with good manufacturing practice. Concerns about the safety of the color additive (1-[4-phenylazophenylazo]-2-napthol (PAN) is the primary color constituent) have been raised due to potential metabolic cleavage of PAN to yield 4-aminoazobenzene. 14C-PAN was applied in a commercially available suntan vehicle containing D&C red no. 17 to viable porcine and non-viable (cadaver) human skin in flow-through diffusion cells. At the end of 24 h, unabsorbed material was removed from the skin and some cells were allowed to continue for an additional 48 h. In human skin, 0.07% and 0.17% of the applied dose were absorbed into the receptor fluid after 24 and 72 h, respectively. At the end of 24 h, 12.5% of the applied dose remained in the skin, which did not decrease at 72 h. When PAN was applied to viable porcine skin for 24 h, 0.3% of the applied dose was absorbed and 12.7% remained in the skin. Additional studies to simulate short-term exposure were completed with PAN applied to the skin for only 15 min, and absorption was determined for 24 and 72 h. These studies in human cadaver skin found 0.02% and 0.08% of the applied dose in the receptor fluid after 24 and 72 h, respectively. Viable porcine skin studies with the 15 min application resulted in receptor fluid values of 0.1% of the applied dose after 24 h. Lipophilic receptor fluids composed of the non-ionic surfactant Volpo 20 at wt% concentrations of 1%, 3%, or 6% in water did not increase partitioning of PAN from the skin into the receptor fluid. No metabolism of PAN was found in viable porcine skin when examined by HPLC. In conclusion, skin absorption of PAN from a commercially available suntan product was low. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Cosmetic Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VITRONECTIN
KW - ABSORPTION
KW - METABOLISM
KW - RHODAMINE B
KW - COSMETICS
KW - SUNTAN
KW - PORCINE somatotropin
KW - DRUG lipophilicity
N1 - Accession Number: 33105191; Yourick, Jeffrey J. 1 Sasik, Camille T. 1 Bronaugh, Robert L. 1; Affiliation: 1: Office of Cosmetics and Colors, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Aug2008, Vol. 30 Issue 4, p310; Subject Term: VITRONECTIN; Subject Term: ABSORPTION; Subject Term: METABOLISM; Subject Term: RHODAMINE B; Subject Term: COSMETICS; Subject Term: SUNTAN; Subject Term: PORCINE somatotropin; Subject Term: DRUG lipophilicity; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/j.1468-2494.2007.00405_5.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Buckley, L. A.
AU - Benson, K.
AU - Davis-Bruno, K.
AU - Dempster, M.
AU - Finch, G. L.
AU - Harlow, P.
AU - Haggerty, H. G.
AU - Hart, T.
AU - Kinter, L.
AU - Leighton, J. K.
AU - McNulty, J.
AU - Roskos, L.
AU - Saber, H.
AU - Stauber, A.
AU - Tabrizi, M.
T1 - Nonclinical Aspects of Biopharmaceutical Development: Discussion of Case Studies at a PhRMA-FDA Workshop.
JO - International Journal of Toxicology (Taylor & Francis)
JF - International Journal of Toxicology (Taylor & Francis)
Y1 - 2008/08//
VL - 27
IS - 4
M3 - Article
SP - 303
EP - 312
PB - Taylor & Francis Ltd
SN - 10915818
AB - Robust assessments of the nonclinical safety profile of biopharmaceuticals are best developed on a scientifically justified, case-by-case basis, with consideration of the therapeutic molecule, molecular target, and differences/similarities between nonclinical species and humans (ICH S6). Significant experience has been gained in the 10 years ensuing since publication of the ICH S6 guidance. In a PhRMA-FDA-sponsored workshop, “Nonclinical Aspects of Biopharmaceutical Development,” industry and US regulatory representatives engaged in exploration of current scientific and regulatory issues relating to the nonclinical development of biopharmaceuticals in order to share scientific learning and experience and to work towards establishing consistency in application of general principles and approaches. The proceedings and discussions of this workshop confirm general alignment of strategy and tactics in development of biopharmaceuticals with regard to such areas as species selection, selection of high doses in toxicology studies, selection of clinical doses, the conduct of developmental and reproductive toxicity (DART) studies, and assessment of carcinogenic potential. However, several important aspects, including, for example, appropriate use of homologues, nonhuman primates, and/or in vitro models in the assessment of risk for potential developmental and carcinogenic effects, were identified as requiring further scientific exploration and discussion. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Toxicology (Taylor & Francis) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pharmacology
KW - Toxicology
KW - Carcinogenicity
KW - Carcinogenicity testing
KW - Drugs -- Case studies
KW - Dosage of drugs
KW - United States
KW - Biopharmaceuticals
KW - Nonclinical
KW - Regulatory
KW - Safety Assessment
N1 - Accession Number: 34506699; Buckley, L. A. 1; Email Address: BuckleyLA@lilly.com; Benson, K. 2; Davis-Bruno, K. 2; Dempster, M. 3; Finch, G. L. 4; Harlow, P. 2; Haggerty, H. G. 5; Hart, T. 6; Kinter, L. 7; Leighton, J. K. 2; McNulty, J. 8; Roskos, L. 9; Saber, H. 2; Stauber, A. 1; Tabrizi, M. 9; Affiliations: 1: Eli Lilly & Co., Greenfield, Indiana, USA; 2: U.S. Food and Drug Administration, Silver Spring, Maryland, USA; 3: Glaxo Smith Kline, Ware, Hertfordshire, UK; 4: Pfizer Inc., Groton, Connecticut, USA; 5: Bristol Myers Squibb, East Syracuse, New York, USA; 6: Glaxo Smith Kline, King of Prussia, Pennsylvania, USA; 7: AstraZeneca, Wilmington, Delaware, USA; 8: AstraZeneca, Waltham, Massachusetts, USA; 9: Medimmune Inc., Hayward, California; Issue Info: Aug2008, Vol. 27 Issue 4, p303; Thesaurus Term: Pharmacology; Thesaurus Term: Toxicology; Thesaurus Term: Carcinogenicity; Thesaurus Term: Carcinogenicity testing; Subject Term: Drugs -- Case studies; Subject Term: Dosage of drugs; Subject: United States; Author-Supplied Keyword: Biopharmaceuticals; Author-Supplied Keyword: Nonclinical; Author-Supplied Keyword: Regulatory; Author-Supplied Keyword: Safety Assessment; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/10915810802367016
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice.
AU - Reynolds, Jeffrey S.
AU - Johnson, Victor J.
AU - Frazer, David G.
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
Y1 - 2008/08//
VL - 105
IS - 2
SP - 711
EP - 717
SN - 87507587
N1 - Accession Number: 34350708; Author: Reynolds, Jeffrey S.: 1 email: jsr0@cdc.gov. Author: Johnson, Victor J.: 2 Author: Frazer, David G.: 1 ; Author Affiliation: 1 Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia: 2 Toxicology and Molecular Biology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; No. of Pages: 7; Language: English; Publication Type: Article; Update Code: 20080917
N2 - An acoustic whole body plethysmograph was developed to estimate specific airway resistance (sRaw) in unrestrained mice. The plethysmograph uses acoustic principles to measure the thoracic breathing pattern and simultaneously measures the airflow entering and/or leaving the plethysmograph. Similarly to traditional methods utilizing a double-chamber plethysmograph, these measurements were combined to estimate sRaw. To evaluate the new system, we placed six conscious A/J mice individually in a whole body plethysmograph (Buxco System) for a 2-min exposure to aerosolized methacholine chloride dissolved in saline (0, 5, 10, and 20 mg/mI), which is known to increase sRaw in mice. Three minutes after exposure, the mice were transferred to the acoustic plethysmograph for 2 mm for data collection. The mean baseline value of sRaw was 0.93 ± 0.10 cmH2O·s. A dose-dependent increase in sRaw was shown, with an approximate tripling of sRaw at the highest dose. These results demonstrate the ability of the system to estimate sRaw based on plethysmograph airflow and acoustic amplitude. ABSTRACT FROM AUTHOR
KW - *PLETHYSMOGRAPHY
KW - *RESPIRATION
KW - HELMHOLTZ resonators
KW - AIRWAY (Medicine)
KW - MICE as laboratory animals
KW - Helmholtz resonator
KW - unrestrained plethysmograph
KW - whole body pIethysmograph
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Sahu, Saura C.
AU - Garthoff, Larry H.
AU - Robi, Martin G.
AU - Chirtel, Stuart J.
AU - Ruggles, Dennis I.
AU - Flynn, Thomas J.
AU - Sobotka, Thomas J.
T1 - Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2008/08//
VL - 28
IS - 6
M3 - Article
SP - 765
EP - 772
SN - 0260437X
AB - The article reports on rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products. It is said that deoxynivalenol (DON) is a mycotoxin food contaminant found in several cereal grains. The literature on the liver toxicity of DON in vivo is conflicting and does not clearly characterize its hepatotoxic effects. Cultures rat liver clone-9 cells were used as a model to assess the hepatotoxic potential of DON. It is said that the cell cultures, were treated at confluence with varying concentrations of DON for 48h at 37 °C in 5% CO2. After the treatment period, the cells were assayed for a number of hepatotoxic endpoints.
KW - RESEARCH
KW - DISEASES
KW - Toxicology
KW - Hepatotoxicology
KW - Liver diseases
KW - Liver cells
KW - Toxic hepatitis
KW - Cell lines
KW - Cell culture
KW - Mycotoxins
KW - clone-9 cell line
KW - deoxynivalenol
KW - hepatocytes
KW - hepatotoxicity
KW - liver toxicity
KW - mycotoxin
N1 - Accession Number: 34136809; Sahu, Saura C. 1; Email Address: saura.sahu@fda.hhs.gov; Garthoff, Larry H. 1; Robi, Martin G. 2; Chirtel, Stuart J. 3; Ruggles, Dennis I. 3; Flynn, Thomas J. 1; Sobotka, Thomas J. 1; Affiliations: 1: Division of Toxicology, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA; 2: Muirkirk Technical Operations Staff, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA; 3: Division of Mathematics, Office of Scientific Analysis and Support, Center for Food Safety and Applied Nutrition. U. S. Food and Drug Administration. Laurel, MD 20708, USA; Issue Info: Aug2008, Vol. 28 Issue 6, p765; Thesaurus Term: RESEARCH; Thesaurus Term: DISEASES; Thesaurus Term: Toxicology; Subject Term: Hepatotoxicology; Subject Term: Liver diseases; Subject Term: Liver cells; Subject Term: Toxic hepatitis; Subject Term: Cell lines; Subject Term: Cell culture; Subject Term: Mycotoxins; Author-Supplied Keyword: clone-9 cell line; Author-Supplied Keyword: deoxynivalenol; Author-Supplied Keyword: hepatocytes; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: liver toxicity; Author-Supplied Keyword: mycotoxin; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article
L3 - 10.1002/jat.1337
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jones, Richard C.
AU - Deck, Joanna
AU - Edmondson, Ricky D.
AU - Hart, Mark E.
T1 - Relative Quantitative Comparisons of the Extracellular Protein Profiles of Staphylococcus aureus UAMS-1 and Its sarA, agr, and sarA agr Regulatory Mutants Using One-Dimensional Polyacrylamide Gel Electrophoresis and Nanocapillary Liquid Chromatography Coupled with Tandem Mass Spectrometry
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008/08//
VL - 190
IS - 15
M3 - Article
SP - 23
EP - 23
SN - 00219193
AB - One-dimensional polyacrylamide gel electrophoresis followed by nanocapillary liquid chromatography coupled with mass spectrometry was used to analyze proteins isolated from Staphylococcus aureus UAMS-1 after 3, 6, 12, and 24 h of in vitro growth. Protein abundance was determined using a quantitative value termed normalized peptide number, and overall, proteins known to be associated with the cell wall were more abundant early on in growth, while proteins known to be secreted into the surrounding milieu were more abundant late in growth. In addition, proteins from spent media and cell lysates of strain UAMS-1 and its isogenic sarA, agr, and sarA agr regulatory mutant strains during exponential growth were identified, and their relative abundances were compared. Extracellular proteins known to be regulated by the global regulators sarA and agr displayed protein levels in accordance with what is known regarding the effects of these regulators. For example, cysteine protease (SspB), endopeptidase (SspA), staphopain (ScpA), and aureolysin (Aur) were higher in abundance in the sarA and sarA agr mutants than in strain UAMS-1. The immunoglobulin G (IgG)-binding protein (Sbi), immunodominant staphylococcal antigen A (IsaA), IgG-binding protein A (Spa), and the heme-iron-binding protein (IsdA) were most abundant in the agr mutant background. Proteins whose abundance was decreased in the sarA mutant included fibrinogen-binding protein (Fib [Efb]), IsaA, lipase 1 and 2, and two proteins identified as putative leukocidin F and S subunits of the two-component leukotoxin family. Collectively, this approach identified 1,263 proteins (matches of two peptides or more) and provided a convenient and reliable way of identifying proteins and comparing their relative abundances. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXTRACELLULAR matrix proteins
KW - STAPHYLOCOCCUS aureus
KW - POLYACRYLAMIDE gel electrophoresis
KW - LIQUID chromatography
KW - MASS spectrometry
KW - BACTERIAL cell walls
N1 - Accession Number: 33553450; Jones, Richard C. 1,2 Deck, Joanna 3 Edmondson, Ricky D. 1,4 Hart, Mark E. 3; Email Address: mark.hart@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502 2: NextGen/PRS, Ann Arbor, MI 48108 3: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502 4: Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72305; Source Info: Aug2008, Vol. 190 Issue 15, p23; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: POLYACRYLAMIDE gel electrophoresis; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: BACTERIAL cell walls; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JB.00383-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Zhiwei
AU - Kotz, Richard M.
T1 - Inference and Sample Size Calculation in the Fit Assessment of Filtering Facepiece Respirators.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/08//
VL - 18
IS - 4
M3 - Article
SP - 713
EP - 723
PB - Taylor & Francis Ltd
SN - 10543406
AB - Filtering facepiece respirators have recently been cleared by the U.S. Food and Drug Administration (FDA) for use by the general public in public health medical emergencies such as pandemic influenza. In the fit assessment of these devices it is important to distinguish between the two sources of variability: population heterogeneity and random fluctuations over repeated donnings. The FDA Special Controls Guidance Document (SCGD) which describes these devices and their evaluation, recommends that the fit performance of a filtering facepiece respirator be evaluated in terms of the proportion of users who will receive a specified level of protection 95% of the time. A point estimator of this proportion is easily obtained under an analysis of variance model, and the SCGD suggests bootstrap as one possible approach to interval estimation. This paper describes a closed-form procedure to obtain confidence intervals and provides sample size formulas. Simulation results suggest that the proposed procedure performs well in realistic settings and compares favorably to two simple bootstrap procedures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORS (Medical equipment)
KW - RESPIRATORY therapy -- Equipment & supplies
KW - MEDICAL emergencies
KW - EMERGENCY medical services
KW - RESPIRATORY infections
KW - VIRUS diseases
KW - Analysis of variance
KW - Delta method
KW - Random effect
KW - Respirator
KW - Sample size
KW - Variance component
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 32990551; Zhang, Zhiwei 1; Email Address: zhiwei.zhang@fda.hhs.gov Kotz, Richard M. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland; Source Info: Aug2008, Vol. 18 Issue 4, p713; Subject Term: RESPIRATORS (Medical equipment); Subject Term: RESPIRATORY therapy -- Equipment & supplies; Subject Term: MEDICAL emergencies; Subject Term: EMERGENCY medical services; Subject Term: RESPIRATORY infections; Subject Term: VIRUS diseases; Author-Supplied Keyword: Analysis of variance; Author-Supplied Keyword: Delta method; Author-Supplied Keyword: Random effect; Author-Supplied Keyword: Respirator; Author-Supplied Keyword: Sample size; Author-Supplied Keyword: Variance component; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 11p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/10543400802071394
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Malinowski, Henry J.
AU - Westelinck, Agnes
AU - Sato, Junko
AU - Ting Ong
T1 - Same Drug, Different Dosing: Differences in Dosing for Drugs Approved in the United States, Europe, and Japan.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2008/08//
VL - 48
IS - 8
M3 - Article
SP - 900
EP - 908
SN - 00912700
AB - With globalization of the pharmaceutical industry, newly approved drugs nearly always become available worldwide, including the 3 major pharmaceutical regions: the United States, Europe, and Japan. One might think that these drugs would have the same recommended dosing throughout the world, but this appears not to be true in many instances. The objective of this study was to identify any patterns of differences in labeled dosing. Approved labeling, for the most widely prescribed proprietary drugs in the United States, was used as a basis for this study. Dosing was compared, for common indications, for the United States, Europe, and Japan. Overall, these data indicate that there are numerous differences in approved dosing for drugs approved in all 3 regions. For about half of the drugs studied, dosing in Japan is considerably lower than the United States or Europe. Some differences in dosing are also apparent between the United States and Europe. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSAGE of drugs
KW - DRUG approval
KW - PHARMACEUTICAL policy
KW - PHARMACOLOGY
KW - UNITED States
KW - EUROPE
KW - JAPAN
KW - dosing
KW - drug safety
KW - exposure response
KW - International
KW - regulatory decisions
N1 - Accession Number: 33332321; Malinowski, Henry J. 1; Email Address: h_malinowski@comcast.net Westelinck, Agnes 2 Sato, Junko 3 Ting Ong 1; Affiliation: 1: US Food and Drug Administration, Rockville, Maryland 2: Hoffmann-LaRoche, Nutley, New Jersey 3: Pharmaceutical and Medical Devices Agency, Tokyo, Japan; Source Info: Aug2008, Vol. 48 Issue 8, p900; Subject Term: DOSAGE of drugs; Subject Term: DRUG approval; Subject Term: PHARMACEUTICAL policy; Subject Term: PHARMACOLOGY; Subject Term: UNITED States; Subject Term: EUROPE; Subject Term: JAPAN; Author-Supplied Keyword: dosing; Author-Supplied Keyword: drug safety; Author-Supplied Keyword: exposure response; Author-Supplied Keyword: International; Author-Supplied Keyword: regulatory decisions; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 9p; Document Type: Article
L3 - 10.1177/0091270008319794
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105793831
T1 - Independent and joint effects of socioeconomic, behavioral, and neighborhood characteristics on physical inactivity and activity levels among US children and adolescents.
AU - Singh GK
AU - Kogan MD
AU - Siahpush M
AU - van Dyck PC
Y1 - 2008/08//
N1 - Accession Number: 105793831. Language: English. Entry Date: 20080822. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7600747.
KW - Behavior
KW - Communities
KW - Physical Activity -- In Adolescence
KW - Physical Activity -- In Infancy and Childhood
KW - Socioeconomic Factors
KW - Adolescence
KW - Age Factors
KW - Chi Square Test
KW - Child
KW - Computers and Computerization
KW - Confidence Intervals
KW - Interviews
KW - Logistic Regression
KW - Odds Ratio
KW - Parental Behavior
KW - Race Factors
KW - Safety
KW - Sex Factors
KW - Sleep
KW - Social Capital
KW - Surveys
KW - Television
KW - United States
KW - Human
SP - 206
EP - 216
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 33
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - This study examines the independent and joint associations between several socioeconomic and behavioral characteristics and physical activity (PA) and inactivity prevalence among 68,288 US children aged 6-17 years. The 2003 National Survey of Children's Health was used to estimate PA prevalence. Multivariate logistic regression was used to estimate odds of activity and inactivity and adjusted prevalence, while least squares regression was used to model mean number of days of physical inactivity (PIA) in past month. The prevalence of PA varied substantially by socioeconomic and behavioral characteristics, with older, female, non-English speaking, and metropolitan children and those with lower socioeconomic status (SES) and neighborhood social capital having higher inactivity and lower activity levels. Children who watched television >/=3 h/day had 60% higher adjusted odds of PIA and 30% lower odds of PA than those who watched television <3 h/day. Children experiencing inadequate sleep during the entire week had 55% higher odds of PIA and 29% lower odds of PA than those who experienced >/=5 nights of adequate sleep during the week. Children whose both parents were physically inactive had 147% higher odds of PIA and 46% lower odds of PA than children whose parents were both physically active. Differentials in PIA by ethnicity, SES, television viewing, and parental inactivity were greater for younger than for older children. Subgroups such as older, female adolescents, children from socially disadvantaged households and neighborhoods, and those in metropolitan areas should be targeted for the promotion of regular physical activity and reduced television viewing time.
SN - 0094-5145
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov.
U2 - PMID: 18373183.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Udey, Mark C.
AU - Rosenberg, Amy S.
T1 - Langerhans Cell Dogma: Another Round of Rejections.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2008/08//
VL - 128
IS - 8
M3 - Article
SP - 1881
EP - 1883
SN - 0022202X
AB - Mice that are deficient in epidermal Langerhans cells allow the functions of these cells in vivo to be rigorously assessed. Experiments that have been carried out with these animals have yielded surprising results, leading to major changes in existing paradigms. In this issue, Obhrai and coworkers explore the involvement of Langerhans cells in skin graft rejection and describe fascinating results.Journal of Investigative Dermatology (2008) 128, 1881–1883. doi:10.1038/jid.2008.167 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LANGERHANS cells
KW - SKIN -- Inflammation
KW - EPIDERMIS
KW - ANIMAL models in research
KW - DERMATOLOGY
KW - RESEARCH
N1 - Accession Number: 33137888; Udey, Mark C. 1; Email Address: udey@helix.nih.gov Rosenberg, Amy S. 2; Affiliation: 1: Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 2: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Aug2008, Vol. 128 Issue 8, p1881; Subject Term: LANGERHANS cells; Subject Term: SKIN -- Inflammation; Subject Term: EPIDERMIS; Subject Term: ANIMAL models in research; Subject Term: DERMATOLOGY; Subject Term: RESEARCH; Number of Pages: 3p; Document Type: Article
L3 - 10.1038/jid.2008.167
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Jeri L.
AU - Spitz, Henry B.
AU - Daniels, Robert D.
T1 - Population Monitoring for Acute Exposure to 210PO.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/08//
VL - 50
IS - 8
M3 - Article
SP - 916
EP - 923
SN - 10762752
AB - The article discusses an investigation of the effectiveness of using single void urine samples in monitoring internal radiation exposure in the event of an incident involving the intentional dispersal of radioactive polonium (210Po). The study involved the evaluation of urinary excretion of 210Po and the calculation of effective doses after an acute unit intake of 210Po. Results showed that 210Po is detectable in single void urine samples at levels that are sufficient to detect effective dose below the recommended limits. It is concluded that analysis of single void urine samples is sufficient to determine whether a person has been exposed to 210Po.
KW - URINALYSIS
KW - POLONIUM
KW - DETECTION of radioactive substances
KW - URINE -- Examination
KW - RADIATION exposure
KW - RADIATION measurements
KW - INDUSTRIAL toxicology
KW - POPULATION health
KW - PUBLIC health
N1 - Accession Number: 34150214; Anderson, Jeri L. 1; Email Address: JLAnderson@cdc.gov Spitz, Henry B. 1 Daniels, Robert D. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio; Source Info: Aug2008, Vol. 50 Issue 8, p916; Subject Term: URINALYSIS; Subject Term: POLONIUM; Subject Term: DETECTION of radioactive substances; Subject Term: URINE -- Examination; Subject Term: RADIATION exposure; Subject Term: RADIATION measurements; Subject Term: INDUSTRIAL toxicology; Subject Term: POPULATION health; Subject Term: PUBLIC health; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 8p; Illustrations: 7 Charts, 2 Graphs; Document Type: Article
L3 - 10.1097/JOM.0b013e318181b4f2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Changning Guo
AU - Gillespie, Stacey R.
AU - Kauffman, John
AU - Doub, William H.
T1 - Comparison of delivery characteristics from a combination metered-dose inhaler using the Andersen cascade impactor and the next generation pharmaceutical impactor.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/08//
VL - 97
IS - 8
M3 - Article
SP - 3321
EP - 3334
SN - 00223549
AB - The purpose of this research was to compare two cascade impaction devices for the aerodynamic particle size assessment of a combination metered-dose inhaler (MDI) product, Combivent®. Particle size analysis was performed using an Anderson Mark II cascade impactor (ACI) and a Next Generation Pharmaceutical Impactor (NGI), both fitted with a preseparator and either a 1 L glass chamber or USP throat, and operated at various flow rates. Particle size distributions (PSDs) and dose delivery profiles were assessed by means of the mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), fine particle fraction <5 micron aerodynamic diameter (FPF<5 µm), and induction port deposition fraction (IPF). Under their normal operating conditions, the ACI (28.3 L/min) and the NGI (30 L/min) yield similar PSDs and dose delivery profiles. However, this equivalent performance for the ACI and the NGI no longer exists at a higher flow rate of 60 L/min. Furthermore, changes in PSD results may also be obtained between different operators and/or when different induction port designs were employed. Thus, it is strongly recommended that special care be taken to eliminate variation in experimental parameters and/or selection of ancillary devices such as the preseparator, induction port or throat, to insure good repeatability and reproducibility when testing inhalation drugs. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 3321–3334, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CASCADE impactors (Meteorological instruments)
KW - ALBUTEROL
KW - ADRENERGIC beta agonists
KW - DRUG delivery systems
KW - PHARMACEUTICAL technology
KW - albuterol sulfate
KW - Andersen Cascade Impactor
KW - Combivent®
KW - Combivent®
KW - dose delivery profile
KW - flow rate
KW - induction port
KW - ipratropium bromide
KW - Next Generation Pharmaceutical Impactor
KW - particle size distribution
N1 - Accession Number: 32750488; Changning Guo 1; Email Address: changning.guo@fda.hhs.gov Gillespie, Stacey R. 1 Kauffman, John 1 Doub, William H. 1; Affiliation: 1: U.S. Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, Missouri 63101; Source Info: Aug2008, Vol. 97 Issue 8, p3321; Subject Term: CASCADE impactors (Meteorological instruments); Subject Term: ALBUTEROL; Subject Term: ADRENERGIC beta agonists; Subject Term: DRUG delivery systems; Subject Term: PHARMACEUTICAL technology; Author-Supplied Keyword: albuterol sulfate; Author-Supplied Keyword: Andersen Cascade Impactor; Author-Supplied Keyword: Combivent®; Author-Supplied Keyword: Combivent®; Author-Supplied Keyword: dose delivery profile; Author-Supplied Keyword: flow rate; Author-Supplied Keyword: induction port; Author-Supplied Keyword: ipratropium bromide; Author-Supplied Keyword: Next Generation Pharmaceutical Impactor; Author-Supplied Keyword: particle size distribution; Number of Pages: 14p; Illustrations: 1 Color Photograph, 4 Charts, 7 Graphs; Document Type: Article
L3 - 10.1002/jps.21203
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zongming Gao
AU - Moore, Terry W.
AU - Doub, William H.
T1 - Vibration effects on dissolution tests with USP apparatuses 1 and 2.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/08//
VL - 97
IS - 8
M3 - Article
SP - 3335
EP - 3343
SN - 00223549
AB - Dissolution testing is of primary importance for drug formulation and quality control. Many sources of variability are accounted for in the apparatus' mechanical calibration process; the effect of vibration on dissolution tests is not well understood in that the test's tolerance for environmental vibration with respect to magnitude or frequency is largely unknown. In this study, USP Apparatuses 1 and 2 were used. Dissolution profiles were obtained for both disintegrating and nondisintegrating tablets. In separate experiments, a lab vacuum pump or a lab mixer, both commonly used in laboratories, was used to generate vibration during dissolution runs with vibration parameters being recorded at a location close to the dissolution vessels. Disintegrating tablets were found to be sensitive to induced vibrations with both the paddle and basket methods. Average dissolution results for nondisintegrating tablets were not sensitive to the studied vibrations; however, variability of the results increased in some cases. The dissolution profiles suggest that the vibration effects on paddle and basket method occur through different mechanisms. The importance of vibration to dissolution test results depends on the vibration source, product being tested and the apparatus type. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 3335–3343, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRATION tests
KW - CLINICAL trials
KW - MEDICAL equipment
KW - CLINICAL drug trials
KW - DRUG monitoring
KW - CLINICAL pharmacology
KW - disintegrating tablet
KW - dissolution testing
KW - nondisintegrating tablet
KW - USP Apparatus 1
KW - USP Apparatus 2
KW - vibration effect
KW - AMERICAN Pharmacists Association
N1 - Accession Number: 32750459; Zongming Gao 1; Email Address: zongming.gao@fda.hhs.gov Moore, Terry W. 1 Doub, William H. 1; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101; Source Info: Aug2008, Vol. 97 Issue 8, p3335; Subject Term: VIBRATION tests; Subject Term: CLINICAL trials; Subject Term: MEDICAL equipment; Subject Term: CLINICAL drug trials; Subject Term: DRUG monitoring; Subject Term: CLINICAL pharmacology; Author-Supplied Keyword: disintegrating tablet; Author-Supplied Keyword: dissolution testing; Author-Supplied Keyword: nondisintegrating tablet; Author-Supplied Keyword: USP Apparatus 1; Author-Supplied Keyword: USP Apparatus 2; Author-Supplied Keyword: vibration effect; Company/Entity: AMERICAN Pharmacists Association; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 9p; Illustrations: 2 Black and White Photographs, 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1002/jps.21242
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zidan, Ahmed S.
AU - Habib, Muhammad J.
AU - Khan, Mansoor A.
T1 - Process analytical technology: Nondestructive evaluation of cyclosporine A and phospholipid solid dispersions by near infrared spectroscopy and imaging.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/08//
VL - 97
IS - 8
M3 - Article
SP - 3388
EP - 3399
SN - 00223549
AB - The objective of this study was to evaluate near infrared (NIR) spectroscopy and imaging as approaches to assess phospholipid compartment within its solid dispersion with cyclosporine A (CyA). By varying dimyristoyl phosphatidylcholine (DMPC) to CyA weight ratio, five batches were prepared by the kneading technique and characterized by DSC and FTIR. A drug/DMPC ratio of 50:1 provided an enhanced dissolution of CyA. FTIR spectra and DSC thermograms revealed a significant interaction between the drug and DMPC which suggested incorporation of CyA within the formed DMPC liposomes. The developed NIR calibration model was able to assess DMPC concentrations within the kneaded products. The calibration and prediction linear plots showed slopes of 0.9711 and 0.9915, offsets of 0.1247 and 0.1080, correlation coefficients of 0.9854 and 0.9889 and root mean square standard errors of 0.43% and 0.42%, respectively. In contrast, NIR spectral imaging was capable of clearly distinguishing the kneaded products, both qualitatively and quantitatively. NIR imaging revealed the poor powder blending efficiency of the method used to prepare physical mixture compared to the efficient distribution of the kneaded products. In conclusion, NIR spectral imaging system provides a rapid approach for acquiring high-resolution spatial and spectral information on solid dispersions. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 3388–3399, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOSPORINE
KW - IMMUNOSUPPRESSIVE agents
KW - PHOSPHOLIPID antibodies
KW - BILAYER lipid membranes
KW - INFRARED spectroscopy
KW - IMAGING systems
KW - cyclosporine
KW - DMPC
KW - near infrared
KW - NIR imaging
KW - solid dispersion
N1 - Accession Number: 32750462; Zidan, Ahmed S. 1 Habib, Muhammad J. 2 Khan, Mansoor A. 3; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Faculty of Pharmacy, Zagazig University, Zagazig, Egypt 2: School of Pharmacy, Howard University, Washington, District of Columbia 3: Division of Product Quality Research, Food and Drug Administration, Rockville, Maryland; Source Info: Aug2008, Vol. 97 Issue 8, p3388; Subject Term: CYCLOSPORINE; Subject Term: IMMUNOSUPPRESSIVE agents; Subject Term: PHOSPHOLIPID antibodies; Subject Term: BILAYER lipid membranes; Subject Term: INFRARED spectroscopy; Subject Term: IMAGING systems; Author-Supplied Keyword: cyclosporine; Author-Supplied Keyword: DMPC; Author-Supplied Keyword: near infrared; Author-Supplied Keyword: NIR imaging; Author-Supplied Keyword: solid dispersion; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; Number of Pages: 12p; Illustrations: 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1002/jps.21238
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105548537
T1 - The mean overall index-RA: a new disease activity measure in rheumatoid arthritis.
AU - Siegel J
Y1 - 2008/08//
N1 - Accession Number: 105548537. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; commentary; editorial. Original Study: Mäkinen H, Kautiainen H, Hannonen P, Sokka T. A new disease activity index for rheumatoid arthritis: Mean Overall Index for Rheumatoid Arthritis (MOI-RA) (J RHEUMATOL) Aug2008; 35 (8): 1522-1527. Journal Subset: Biomedical; Blind Peer Reviewed; Canada; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 7501984.
KW - Arthritis, Rheumatoid -- Diagnosis
KW - Clinical Assessment Tools
SP - 1480
EP - 1481
JO - Journal of Rheumatology
JF - Journal of Rheumatology
JA - J RHEUMATOL
VL - 35
IS - 8
CY - Toronto, Ontario
PB - Journal of Rheumatology
SN - 0315-162X
AD - Clinical Team Leader, US Food and Drug Administration, Division of Anesthesia, Analgesia, and Rheumatology Products, Silver Spring, Maryland, USA.
U2 - PMID: 18671319.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105660080
T1 - Structural model analysis of HIV risk behaviors among sexually active minority adolescents.
AU - Bellamy ND
AU - Wang MQ
AU - Matthew RF
AU - Leitao MP
AU - Agee RA
AU - Yan AF
AU - Bellamy, Nikki D
AU - Wang, Min Qi
AU - Matthew, Resa F
AU - Leitao, Marion P
AU - Agee, Rená A
AU - Yan, Alice F
Y1 - 2008/08//2008 Aug
N1 - Accession Number: 105660080. Language: English. Entry Date: 20081003. Revision Date: 20151231. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: 277-00-6207//PHS HHS/United States. NLM UID: 7503090.
KW - HIV Infections -- Epidemiology
KW - Minority Groups -- Statistics and Numerical Data
KW - Models, Theoretical
KW - Risk Taking Behavior
KW - Sexuality
KW - Adolescence
KW - Adolescent Health Services
KW - Blacks -- Statistics and Numerical Data
KW - Cross Sectional Studies
KW - Demography
KW - Educational Status
KW - Female
KW - Funding Source
KW - Hispanics -- Statistics and Numerical Data
KW - Male
KW - Risk Factors
KW - Substance Use Disorders -- Epidemiology
KW - United States
KW - Human
SP - 914
EP - 924
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
JA - J NATL MED ASSOC
VL - 100
IS - 8
CY - New York, New York
PB - Elsevier Science
AB - Unlabelled: Contents of this article are solely the responsibility of the authors and do not necessarily reflect the opinions, official policy or position of the U.S. Department of Health and Human Services, the Substance Abuse and Mental Health Services Administration or Centers for Mental Health Services and Substance Abuse Prevention.Objective: To evaluate an HIV risk profile in sexually active black and Hispanic adolescents using a structural equation model (SEM).Method: Grantees from 15 states and Washington, DC, were selected to participate in the study. Black and Hispanic adolescents (N = 2,371) who completed the baseline instrument were required to have experienced vaginal, oral or anal sex in order to be included in this study. Total minority youths who self-reported as black but not Hispanic were n = 1,455 and for Hispanic n = 916.Results: The hypothesized model fit moderately well (CFI = 0.940, TLI = 0.928, RMSEA = 0.039). The key significant direct effect was found (P < 0.05) for higher alcohol, tobacco and other drug use related to nonuse of condoms, more sex partners and use of substances before sex.Conclusion: Current findings underscore the need to incorporate culturally sensitive strategies in developing programs for minority youth. However, given that minority group members often report greater experiences of discrimination than whites, future research in this area should also include an examination of the role of other stressors such as racial disparities and their potential cumulative impact on minority youth and their risks for alcohol, tobacco and other drug use and HIV.
SN - 0027-9684
AD - Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Prevention, Traumatic Stress and Special Programs, 1 Choke Cherry Road, Room 6-1003, Rockville, MD 20857, USA
AD - Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Prevention, Traumatic Stress and Special Programs, Rockville, MD
U2 - PMID: 18717142.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ena Lee
AU - Hee Jin Kim
AU - Ji Young Im
AU - Jeonga Kim
AU - Hyeyoung Park
AU - Ju Young Ryu
AU - Jaewon Lee
AU - Keun Aee Shim
AU - Kee Kyung Jung
AU - Soon Young Han
AU - Byung Mu Lee
AU - Seung Hee Kim
AU - Hyung Sik Kim
T1 - Hypothyroidism protects di(n-butyl) phthalate-induced reproductive organs damage in Sprague-Dawley male rats.
JO - Journal of Toxicological Sciences
JF - Journal of Toxicological Sciences
Y1 - 2008/08//
VL - 33
IS - 3
M3 - Article
SP - 299
EP - 306
SN - 03881350
AB - This study examined the deleterious effects of di(n-butyl) phthalate (DBP) on the male reproductive organs in hypothyroid rats. Hypothyroidism was induced in prepubertal male rats (28 days of age) by an intraperitonial (i.p.) injection of 10 mg/kg/day propylthiouracil (PTU) for 30 days. DBP (100 and 500 mg/kg/day) was administered by oral gavages to the intact or hypothyroid rats for 30 days. The body weight of the PTU-treated rats was significantly lower than the control group. The total triiodothyronine (T3) and thyroxine (T4) serum level was lower, and the thyroid stimulating hormone (TSH) level was higher in the hypothyroid rats than in the control rats. The DBP treatment rats showed significantly lower testes, epididymides, seminal vesicles, and ventral prostate weights than the untreated rats. The hypothyroid rats had significantly higher thyroid weights and lower adrenal glands weights than the control rats. The histomorphological examination showed diffused Leydig cells hyperplasias and germ cells loss in the DBP (500 mg/kg)-treated rats, whereas these effects were mild in the DBP-treated hypothyroid rats. The serum levels of monobutyl phthalate (MBP) were significantly lower in PTU-induced hypothyroid rats than in the DBP-treated rats. This data suggests that the hypothyroid status might offer some protection from male reproductive organ toxicity caused by a disturbance in the metabolic activation of the parent compound, DBP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicological Sciences is the property of Japanese Society of Toxicology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPOTHYROIDISM
KW - GENITALIA
KW - THYROXINE
KW - SPRAGUE Dawley rats
KW - RATS as laboratory animals
KW - Di(n-butyl) phthalate
KW - Hypothyroidism
KW - Metabolic activation
KW - Monobutyl phtalate
KW - Testis
KW - Thyroid hormone
N1 - Accession Number: 34448439; Ena Lee 1 Hee Jin Kim 1 Ji Young Im 1 Jeonga Kim 1 Hyeyoung Park 1 Ju Young Ryu 1 Jaewon Lee 1 Keun Aee Shim 2 Kee Kyung Jung 3 Soon Young Han 3 Byung Mu Lee 2 Seung Hee Kim 3 Hyung Sik Kim 1; Email Address: hkims@pusan.ac.kr; Affiliation: 1: College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Geujeong-gu, Busan 609-735, Korea 2: Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun-Dong 300, Changan-Ku, Kyunggi-Do, Suwon, 440-746, Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Korea; Source Info: Aug2008, Vol. 33 Issue 3, p299; Subject Term: HYPOTHYROIDISM; Subject Term: GENITALIA; Subject Term: THYROXINE; Subject Term: SPRAGUE Dawley rats; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: Di(n-butyl) phthalate; Author-Supplied Keyword: Hypothyroidism; Author-Supplied Keyword: Metabolic activation; Author-Supplied Keyword: Monobutyl phtalate; Author-Supplied Keyword: Testis; Author-Supplied Keyword: Thyroid hormone; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Black and White Photograph, 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Prospero, Emilia
AU - Barbadoro, Pamela
AU - Filippetti, Fabio
AU - Appignanesi, Remo
AU - Ciavattini, Andrea
AU - Carle, Flavia
T1 - Occurrence of Neural Tube Defects in Pregnancy: An Excess of Cases in a 2773-km2 Area in Central Italy.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/08//
VL - 71
IS - 15
M3 - Article
SP - 981
EP - 983
SN - 15287394
AB - Neural tube defects (NTDs) have a complex and imperfectly understood etiology, in which both genetic and environmental factors might be involved. The aim of the study was to describe an excess of cases of NTDs in a small area in central Italy. Over a 2-wk period in autumn 2002, three diagnoses of anencephaly were made in a 2773-km2 area. As a consequence of these events, information on known risk factors as well as data on environmental changes, or epidemics of infectious diseases, in 2002-2004, were collected. The NTD rate was estimated for 10,000 births (live and stillborn) in this area. The 95% confidence intervals of rates were estimated assuming Poisson distribution of cases. Six cases of NTD were observed, with an NTD prevalence rate of 18.5 per 10,000 births (95% CI 17.0, 20.12). No evidence of known risk factors was reported. During summer 2002, the local service for environmental surveillance observed that the threshold level of drinking-water bacterial contamination had been exceeded, which probably resulted in an adjustment in the amount of chlorine added. The major difficulty in making hypotheses regarding the causes of birth defects is linking environmental risk factors exposure to fetal outcome. The prompt gathering of data may be essential. Thus, we emphasize the need for the activation of a population-based congenital malformation registry in order to achieve a deeper understanding of these events etiology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES -- Causes & theories of causation
KW - NEURAL tube -- Abnormalities
KW - PREGNANCY
KW - HUMAN abnormalities
KW - GENETIC disorders in pregnancy
KW - DISEASES -- Risk factors
KW - ANENCEPHALY
KW - MYELOMENINGOCELE
KW - ITALY
N1 - Accession Number: 32746186; Prospero, Emilia 1; Email Address: e.prospero@univpm.it Barbadoro, Pamela 2 Filippetti, Fabio 3 Appignanesi, Remo 3 Ciavattini, Andrea 4 Carle, Flavia 5; Affiliation: 1: Università Politecnicà delle Marche, Ancona, Italy 2: School of Public Health, Università Politecnica delle Marche, Ancona, Italy 3: Public Health Service, Regione Marche, Ancona, Italy 4: Institute of Obstetrics and Gynaecology, Università Politecnica delle Marche, Ancona, Italy 5: Department of Epidemiology, Biostatistics and Medical Information Technology, Università Politecnica delle Marche, Ancona, Italy; Source Info: Aug2008, Vol. 71 Issue 15, p981; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: NEURAL tube -- Abnormalities; Subject Term: PREGNANCY; Subject Term: HUMAN abnormalities; Subject Term: GENETIC disorders in pregnancy; Subject Term: DISEASES -- Risk factors; Subject Term: ANENCEPHALY; Subject Term: MYELOMENINGOCELE; Subject Term: ITALY; Number of Pages: 3p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/15287390701838531
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Martinez, M.
AU - Modric, S.
AU - Sharkey, M.
AU - Troutman, L.
AU - Walker, L.
AU - Mealey, K.
T1 - The pharmacogenomics of P-glycoprotein and its role in veterinary medicine.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2008/08//
VL - 31
IS - 4
M3 - Article
SP - 285
EP - 300
PB - Wiley-Blackwell
SN - 01407783
AB - Despite advancements in pharmacogenetics in human medicine, the incorporation of pharmacogenetics into veterinary medicine is still in its early stages of development. To date, efforts to understand the pharmacologic impact of genetic variation in veterinary species have largely focused on genes encoding for the membrane transporter, P-glycoprotein (P-gp). The emphasis on the role of P-gp is largely because of safety concerns associated with the use of some macrocyclic lactones in dogs. Because of the body of information available on this topic, we use P-gp as a platform for understanding the importance of population diversity in veterinary medicine. The impact of P-gp on drug pharmacokinetics and pharmacodynamics is considered, along with endogenous and exogenous factors that can modulate P-gp activity. The review includes discussion of how population diversity in P-gp activity can lead to susceptibility to certain diseases or alter patient response to environmental stress or pharmaceutical intervention. In addition, phenotypic diversity also needs to be considered, as demonstrated by the impact of P-gp up-regulation and drug resistance. The aim of this review was to set the stage for further exploration into the impact of genetic and phenotypic variability on drug pharmacokinetics, disease propensity, product formulation and drug response in both companion and food-producing animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - VETERINARY medicine
KW - GENETICS
KW - GLYCOPROTEINS
KW - PHARMACOKINETICS
KW - DOGS as laboratory animals
N1 - Accession Number: 34185617; Martinez, M. 1; Email Address: marilyn.martinez@fda.hhs.gov Modric, S. 1 Sharkey, M. 1 Troutman, L. 1 Walker, L. 1 Mealey, K. 2; Affiliation: 1: Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD, USA 2: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Source Info: Aug2008, Vol. 31 Issue 4, p285; Subject Term: PHARMACOGENOMICS; Subject Term: VETERINARY medicine; Subject Term: GENETICS; Subject Term: GLYCOPROTEINS; Subject Term: PHARMACOKINETICS; Subject Term: DOGS as laboratory animals; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 16p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1365-2885.2008.00964.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Argaw, Takele
AU - Figueroa, Mariel
AU - Salomon, Daniel R.
AU - Wilson, Carolyn A.
T1 - Identification of Residues outside of the Receptor Binding Domain That Influence the Infectivity and Tropism of Porcine Endogenous Retrovirus.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008/08//
VL - 82
IS - 15
M3 - Article
SP - 7483
EP - 7491
SN - 0022538X
AB - Identification of determinants of human tropism of porcine endogenous retrovirus (PERV) is critical to understanding the risk of transmission of PERV to recipients of porcine xenotransplantation products. Previously, we showed that a chimeric envelope cDNA encoding the 360 N-terminal residues of the human-tropic PERV envelope class A (PERV-A) SU and the 130 C-terminal residues of the pig-tropic PERV-C SU and all of TM (PERV-A/C) showed a 100-fold decrease in infectivity titer on human cells (M. Gemeniano, O. Mpanju, D. R. Salomon, M. V. Eiden, and C. A. Wilson, Virology 346:108-117, 2006). To identify residues important for human cell infection, we performed site-directed mutagenesis on each of the nine residues, singly or in combination, that distinguish the C-terminal region of PERV-C from PERV-A. Of the nine amino acids, two single-amino-acid substitutions, Q374R and I412V, restored the infectivity of human cells to the chimeric PERV-A/C to a titer equivalent to that of PERV-A. In contrast, PERV-A/C mutant envelope Q439P resulted in undetectable infection of human cells and an approximately 1,000-fold decrease in control pig cells. Mutation of K441R rescued mutants that carried Q439P, suggesting an incompatibility between the proline residue at this position and the presence of KK in the proteolytic cleavage signal. We confirmed this incompatibility with vectors carrying PERV-A envelope mutant R462K that were also rendered noninfectious. Finally, tropism of vectors carrying PERV-C envelope mutants with only four amino acid changes in the C terminus of PERV-C envelope, NHRQ436YNRP plus K441R, was shifted to one similar to that of PERV-A. Our results show an important and previously unrecognized role for infectivity and tropism for residues at the C terminus of SU. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY virology
KW - TERATOGENESIS
KW - ABNORMALITIES in animals
KW - VIRUS diseases
KW - MICROBIOLOGY
N1 - Accession Number: 33560785; Argaw, Takele 1 Figueroa, Mariel 1 Salomon, Daniel R. 2 Wilson, Carolyn A. 1; Email Address: carolyn.wilson@fda.hhs.gov; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Building 29B, Room 5NN22, HFM 725, 8800 Rockville Pike, Bethesda, Maryland 2: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 930372; Source Info: Aug2008, Vol. 82 Issue 15, p7483; Subject Term: VETERINARY virology; Subject Term: TERATOGENESIS; Subject Term: ABNORMALITIES in animals; Subject Term: VIRUS diseases; Subject Term: MICROBIOLOGY; Number of Pages: 9p; Document Type: Article
L3 - 10.1128/JVI.00295-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parks, C. G.
AU - Cooper, G. S.
AU - Dooley, M. A.
AU - Park, M. M.
AU - Treadwell, E. L.
AU - Gilkeson, G. S.
T1 - Childhood agricultural and adult occupational exposures to organic dusts in a population-based case-control study of systemic lupus erythematosus.
JO - Lupus
JF - Lupus
Y1 - 2008/08//
VL - 17
IS - 8
M3 - Article
SP - 711
EP - 719
PB - Sage Publications Inc.
SN - 09612033
AB - Organic dust exposure can influence the development and symptoms of immune-related diseases such as atopy and asthma, but has rarely been examined in relation to systemic autoimmunity. The present analyses explore the association of lifetime farm and occupational organic dust exposures with systemic lupus erythematosus (SLE) in recently diagnosed patients (n = 265) compared with controls (n = 355) frequency matched by age, sex and state. Questionnaire data included childhood farm residence, childhood and adult experience with specific crops, and adult work in textiles, hog or poultry processing and paper or furniture manufacture. Adjusted odds ratios (OR) and 95% confidence intervals (Cl) were estimated by logistic regression models including age, sex, state, race, education and silica exposure. Overall childhood or adult farm contact and childhood farm residence were not associated with SLE. Farm contact with livestock was inversely associated with SLE(OR = 0.55, 95% Cl 0.35, 0.88). This effect was most pronounced among those with childhood farm residence and both childhood and adult livestock exposure (OR = 0.19; 95% Cl 0.06, 0.63), but was difficult to separate from adult exposure to grains or corn. Other adult occupational exposures were not associated with SLE risk overall, regardless of childhood farm residence or livestock exposure, although an inverse association was seen among non-smokers (OR = 0.59; 95% Cl 0.33, 1.1), particularly for textile work (OR = 0.34; 95% CI 0.19, 0.64). These exploratory findings support the development of studies to specifically investigate the effects of organic dust exposure on SLE risk, with particular attention to exposure assessment and characterization of demographics, smoking and other occupational exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYSTEMIC lupus erythematosus
KW - IMMUNOLOGIC diseases
KW - ENDOTOXINS
KW - OCCUPATIONAL hazards
KW - AUTOIMMUNITY
KW - RESPIRATORY allergy
KW - AUTOIMMUNE diseases
KW - endotoxins
KW - epidemiology
KW - hygiene hypothesis
KW - livestock
KW - occupational exposure
KW - systemic lupus erythematosus
N1 - Accession Number: 34285527; Parks, C. G. 1,2; Email Address: parksI@mail.nih.gov Cooper, G. S. 3 Dooley, M. A. 4 Park, M. M. 4 Treadwell, E. L. 5 Gilkeson, G. S. 6; Affiliation: 1: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA 3: United States Environmental Protection Agency, Washington, District of Columbia, USA 4: Division of Rheumatology, University of North Carolina, Chapel Hill, North Carolina, USA 5: Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina, USA 6: Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA; Source Info: Aug2008, Vol. 17 Issue 8, p711; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: IMMUNOLOGIC diseases; Subject Term: ENDOTOXINS; Subject Term: OCCUPATIONAL hazards; Subject Term: AUTOIMMUNITY; Subject Term: RESPIRATORY allergy; Subject Term: AUTOIMMUNE diseases; Author-Supplied Keyword: endotoxins; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hygiene hypothesis; Author-Supplied Keyword: livestock; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: systemic lupus erythematosus; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jiang Li
AU - Uitert, Robert Van
AU - Jianhua Yao
AU - Petrick, Nicholas
AU - Franaszek, Marek
AU - Huang, Adam
AU - Summers, Ronald M.
T1 - Wavelet method for CT colonography computer-aided polyp detection.
JO - Medical Physics
JF - Medical Physics
Y1 - 2008/08//
VL - 35
IS - 8
M3 - Article
SP - 3527
EP - 3538
SN - 00942405
AB - Computed tomographic colonography (CTC) computer aided detection (CAD) is a new method to detect colon polyps. Colonic polyps are abnormal growths that may become cancerous. Detection and removal of colonic polyps, particularly larger ones, has been shown to reduce the incidence of colorectal cancer. While high sensitivities and low false positive rates are consistently achieved for the detection of polyps sized 1 cm or larger, lower sensitivities and higher false positive rates occur when the goal of CAD is to identify “medium”-sized polyps, 6–9 mm in diameter. Such medium-sized polyps may be important for clinical patient management. We have developed a wavelet-based postprocessor to reduce false positives for this polyp size range. We applied the wavelet-based postprocessor to CTC CAD findings from 44 patients in whom 45 polyps with sizes of 6–9 mm were found at segmentally unblinded optical colonoscopy and visible on retrospective review of the CT colonography images. Prior to the application of the wavelet-based postprocessor, the CTC CAD system detected 33 of the polyps (sensitivity 73.33%) with 12.4 false positives per patient, a sensitivity comparable to that of expert radiologists. Fourfold cross validation with 5000 bootstraps showed that the wavelet-based postprocessor could reduce the false positives by 56.61% (p<0.001), to 5.38 per patient (95% confidence interval [4.41, 6.34]), without significant sensitivity degradation (32/45, 71.11%, 95% confidence interval [66.39%, 75.74%], p=0.1713). We conclude that this wavelet-based postprocessor can substantially reduce the false positive rate of our CTC CAD for this important polyp size range. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON (Anatomy) -- Tomography
KW - COMPUTER simulation
KW - COLON cancer
KW - ENDOSCOPY
KW - DIAGNOSTIC imaging
KW - CAD
KW - CT colonography
KW - false positive reduction
KW - SVM committee
KW - wavelet
N1 - Accession Number: 33520462; Jiang Li 1 Uitert, Robert Van 1 Jianhua Yao 1 Petrick, Nicholas 2 Franaszek, Marek 1 Huang, Adam 1 Summers, Ronald M. 1; Affiliation: 1: Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1182 2: National Institute of Biomedical Imaging and Bioengineering (NIBIB)/Center for Devices and Radiological Health (CDRH) Joint Laboratory for the Assessment of Medical Imaging Systems, U.S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993-0002; Source Info: Aug2008, Vol. 35 Issue 8, p3527; Subject Term: COLON (Anatomy) -- Tomography; Subject Term: COMPUTER simulation; Subject Term: COLON cancer; Subject Term: ENDOSCOPY; Subject Term: DIAGNOSTIC imaging; Author-Supplied Keyword: CAD; Author-Supplied Keyword: CT colonography; Author-Supplied Keyword: false positive reduction; Author-Supplied Keyword: SVM committee; Author-Supplied Keyword: wavelet; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 12p; Illustrations: 1 Color Photograph, 4 Black and White Photographs, 6 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1118/1.2938517
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chapman, Louisa E.
AU - Sullivent, Ernest E.
AU - Grohskopf, Lisa A.
AU - Beltrami, Elise M.
AU - Perz, Joseph F.
AU - Kretsinger, Katrina
AU - Panlilio, Adelisa L.
AU - Thompson, Nicola D.
AU - Ehrenberg, Richard L.
AU - Gensheimer, Kathleen F.
AU - Duchin, Jeffrey S.
AU - Kilmarx, Peter H.
AU - Hunt, Richard C.
T1 - Recommendations for Postexposure Interventions to Prevent Infection with Hepatitis B Virus, Hepatitis C Virus, or Human Immunodeficiency Virus, and Tetanus in Persons Wounded During Bombings and Other Mass-Casualty Events -- United States, 2008.
JO - MMWR Recommendations & Reports
JF - MMWR Recommendations & Reports
Y1 - 2008/08//8/1/2008
VL - 57
IS - RR-6
M3 - Article
SP - 1
EP - CE-4
PB - Centers for Disease Control & Prevention (CDC)
SN - 10575987
AB - This report outlines recommendations for postexposure interventions to prevent infection with hepatitis B virus, hepatitis C virus, or human immunodeficiency virus, and tetanus in persons wounded during bombings or other events resulting in mass casualties. Persons wounded during such events or in conjunction with the resulting emergency response might be exposed to blood, body fluids, or tissue from other injured persons and thus be at risk for bloodborne infections. This report adapts existing general recommendations on the use of immunization and postexposure prophylaxis for tetanus and for occupational and nonoccupational exposures to bloodborne pathogens to the specific situation of a mass-casualty event. Decisions regarding the implementation of prophylaxis are complex, and drawing parallels from existing guidelines is difficult. For any prophylactic intervention to be implemented effectively, guidance must be simple, straightforward, and logistically undemanding. Critical review during development of this guidance was provided by representatives of the National Association of County and City Health Officials, the Council of State and Territorial Epidemiologists, and representatives of the acute injury care, trauma and emergency response medical communities participating in CDC's Terrorism Injuries: Information, Dissemination and Exchange (TIIDE) project. The recommendations contained in this report represent the consensus of U.S. federal public health officials and reflect the experience and input of public health officials at all levels of government and the acute injury response community. [ABSTRACT FROM AUTHOR]
AB - Copyright of MMWR Recommendations & Reports is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases -- Prevention
KW - HEPATITIS B virus
KW - HEPATITIS C virus
KW - HIV (Viruses)
KW - TETANUS
KW - MASS casualties
KW - PUBLIC health -- United States
KW - UNITED States
N1 - Accession Number: 34195250; Chapman, Louisa E. 1; Email Address: LChapman@cdc.gov Sullivent, Ernest E. 2 Grohskopf, Lisa A. 3 Beltrami, Elise M. 4 Perz, Joseph F. 5 Kretsinger, Katrina 6 Panlilio, Adelisa L. 4 Thompson, Nicola D. 5 Ehrenberg, Richard L. 7 Gensheimer, Kathleen F. 8,9 Duchin, Jeffrey S. 10,11 Kilmarx, Peter H. 3 Hunt, Richard C. 2; Affiliation: 1: Immunization Services Division, National Center for Immunizations and Respiratory Diseases 2: Division of Injury Response, National Center for Injury Prevention and Control 3: Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 4: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases 5: Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 6: Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases 7: Office of Emergency Preparedness and Response, National Institute for Occupational Safety and Health 8: Council of State and Territorial Epidemiologists, Atlanta, Georgia 9: Maine Department of Health and Human Services, Augusta, Maine 10: National Association of County and City Health Officials, Washington, DC 11: Public Health -- King County, Seattle, Washington; Source Info: 8/1/2008, Vol. 57 Issue RR-6, p1; Subject Term: VIRUS diseases -- Prevention; Subject Term: HEPATITIS B virus; Subject Term: HEPATITIS C virus; Subject Term: HIV (Viruses); Subject Term: TETANUS; Subject Term: MASS casualties; Subject Term: PUBLIC health -- United States; Subject Term: UNITED States; Number of Pages: 25p; Illustrations: 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Jinhai
AU - Lozier, Jay
AU - Johnson, Gibbes
AU - Kirshner, Susan
AU - Verthelyi, Daniela
AU - Pariser, Anne
AU - Shores, Elizabeth
AU - Rosenberg, Amy
T1 - Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2008/08//
VL - 26
IS - 8
M3 - Article
SP - 901
EP - 908
SN - 10870156
AB - Lysosomal storage diseases are characterized by deficiencies in lysosomal enzymes, allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme replacement therapy is the principal treatment for most of these diseases. However, these therapies are often complicated by immune responses to the enzymes, blocking efficacy and causing severe adverse outcomes by neutralizing product activity. It is thus crucial to understand the relationships between genetic mutations, endogenous residual enzyme proteins (cross-reactive immunologic material), development of neutralizing antibodies and their impact on clinical outcomes of lysosomal storage diseases. For patients in whom neutralizing antibodies may cause severe adverse clinical outcomes, it is paramount to develop tolerance inducing protocols to preclude, where predictable, or treat such life-threatening responses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Biotechnology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Lysosomal storage diseases -- Treatment
KW - Immunoglobulins
KW - Drug tolerance
KW - Gaucher's disease -- Treatment
KW - Glycogen storage disease type II -- Treatment
KW - Immunology
KW - Hemophilia -- Complications
N1 - Accession Number: 33551957; Wang, Jinhai 1; Lozier, Jay 2; Johnson, Gibbes 1; Kirshner, Susan 1; Verthelyi, Daniela 1; Pariser, Anne 3; Shores, Elizabeth 1; Rosenberg, Amy 1; Affiliations: 1: Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, NIH Building 29B, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.; 2: Department of Laboratory Medicine, NIH Clinical Center, Bethesda, Maryland 20892, USA.; 3: Division of Gastroenterology Products, Office of New Drugs, Center for Drug Evaluation and Research, FDA, White Oak, Bldg. 22, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, USA.; Issue Info: Aug2008, Vol. 26 Issue 8, p901; Thesaurus Term: RESEARCH; Subject Term: Lysosomal storage diseases -- Treatment; Subject Term: Immunoglobulins; Subject Term: Drug tolerance; Subject Term: Gaucher's disease -- Treatment; Subject Term: Glycogen storage disease type II -- Treatment; Subject Term: Immunology; Subject Term: Hemophilia -- Complications; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1038/nbt.1484
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zhou, Zheng
AU - Feng, Hanqiao
AU - Hansen, D Flemming
AU - Kato, Hidenori
AU - Luk, Ed
AU - Freedberg, Daron I
AU - Kay, Lewis E
AU - Wu, Carl
AU - Bai, Yawen
T1 - NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2008/08//
VL - 15
IS - 8
M3 - Article
SP - 868
EP - 869
PB - Nature Publishing Group
SN - 15459993
AB - The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short α-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance
KW - YEAST
KW - MOLECULAR chaperones
KW - HISTONES
KW - MOLECULAR models
N1 - Accession Number: 33467820; Zhou, Zheng 1 Feng, Hanqiao 1 Hansen, D Flemming 2 Kato, Hidenori 1 Luk, Ed 1 Freedberg, Daron I 3 Kay, Lewis E 2 Wu, Carl 1 Bai, Yawen 1; Email Address: yawen@helix.nih.gov; Affiliation: 1: Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA 2: Department of Medical Genetics, Biochemistry and Chemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada 3: NMR Spectroscopy Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA; Source Info: Aug2008, Vol. 15 Issue 8, p868; Subject Term: NUCLEAR magnetic resonance; Subject Term: YEAST; Subject Term: MOLECULAR chaperones; Subject Term: HISTONES; Subject Term: MOLECULAR models; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 2p; Illustrations: 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.1038/nsmb.1465
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33467820&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105627975
T1 - Meth mouth.
AU - Heng CK
AU - Badner VM
AU - Schiop LA
Y1 - 2008/08//
N1 - Accession Number: 105627975. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Dental Care. NLM UID: 0414634.
KW - Central Nervous System Stimulants -- Adverse Effects
KW - Dental Caries -- Chemically Induced
KW - Methamphetamine -- Adverse Effects
KW - Substance Use Disorders -- Complications
KW - Xerostomia -- Chemically Induced
KW - Dental Caries -- Prevention and Control
KW - Mouth Diseases -- Chemically Induced
KW - Mouth Diseases -- Prevention and Control
SP - 50
EP - 51
JO - New York State Dental Journal
JF - New York State Dental Journal
JA - N Y STATE DENT J
VL - 74
IS - 5
CY - Albany, New York
PB - New York State Dental Journal
SN - 0028-7571
AD - US Public Health Service, Federal Correctional Institution, Danbury, CT, USA. cheng@bop.gov
U2 - PMID: 18982966.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105807522
T1 - Device safety. Cutting a battery pack cable can start a fire.
AU - Mirsaidi N
Y1 - 2008/08//2008 Aug
N1 - Accession Number: 105807522. Language: English. Entry Date: 20080905. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety
KW - Fires -- Etiology
KW - Therapeutic Irrigation -- Equipment and Supplies
KW - Power Sources
SP - 13
EP - 14
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse-consultant for general and plastic surgery devices at the Center for Devices and Radiological Health.
U2 - PMID: 18648273.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105807522&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Quitting Smoking: Helping Patients Kick the Habit.
JO - Nursing for Women's Health
JF - Nursing for Women's Health
Y1 - 2008/08//Aug/Sep2008
VL - 12
IS - 4
M3 - Article
SP - 282
EP - 284
SN - 17514851
AB - The article presents suggestions to nurses and other health care providers for helping women patients to quit smoking in the U.S. It informs that the use of pharmacotherapy may help, including a nicotine gum or any of the seven medications approved for smoking cessation by the U.S. Food and Drug Administration. It is suggested that tobacco users should be assisted with a plan, including advice to set a quit date, avoiding other smokers and abstaining from alcohol use.
KW - SMOKING cessation
KW - WOMEN patients
KW - DRUG therapy
KW - CIGARETTE smokers
KW - NURSES
KW - NICOTINE
KW - UNITED States. Food & Drug Administration
KW - UNITED States
N1 - Accession Number: 33864258; Clancy, Carolyn M. 1; Source Information: Aug/Sep2008, Vol. 12 Issue 4, p282; Subject: SMOKING cessation; Subject: WOMEN patients; Subject: DRUG therapy; Subject: CIGARETTE smokers; Subject: NURSES; Subject: NICOTINE; Subject: UNITED States. Food & Drug Administration; Geographic Terms: UNITED States; Number of Pages: 3p; Illustrations: 3 Color Photographs; Document Type: Article
L3 - 10.1111/j.1751-486X.2007.00341.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105670072
T1 - Quitting smoking: helping patients kick the habit.
AU - Clancy CM
Y1 - 2008/08//Aug/Sep2008
N1 - Accession Number: 105670072. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Public Health; Women's Health. NLM UID: 101304602.
KW - Nurse-Patient Relations
KW - Nursing Role
KW - Smoking Cessation
KW - Female
KW - Information Resources
KW - Patient Education
KW - Pregnancy
KW - Smoking -- Epidemiology
KW - Smoking -- In Pregnancy
KW - World Wide Web
SP - 282
EP - 285
JO - Nursing for Women's Health
JF - Nursing for Women's Health
JA - NURS WOMENS HEALTH
VL - 12
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1751-4851
AD - Director, Agency for Healthcare Research and Quality, Rockville, MD
U2 - PMID: 18715374.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Trumbo, Paula R.
T1 - Challenges with using chronic disease endpoints in setting dietary reference intakes.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008/08//
VL - 66
IS - 8
M3 - Article
SP - 459
EP - 464
SN - 00296643
AB - Since 1941, the recommended dietary allowances (RDAs) in the United States have been based on the goal of maintaining health in the country's population. There has been a growing body of evidence to support the role of diet in reducing the risk of chronic diseases. For this reason, there has been recent emphasis on considering data on chronic disease endpoints for setting dietary reference intakes (DRIs). Despite this emphasis, none of the RDAs set during the DRI review were based on chronic disease risk. However, chronic disease risk was considered for determining adequate intakes and even some acceptable macronutrient distribution ranges. This article discusses the application of and challenges associated with using chronic disease endpoints in setting DRIs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition Reviews is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diet in disease
KW - Chronic diseases -- Risk factors
KW - Determinants (Mathematics)
KW - Elemental diet
KW - Public health -- United States
KW - United States
KW - age-related eye diseases
KW - anthocyanins
KW - chronic disease
KW - dietary reference intakes
KW - lutein
KW - oxidative stress
KW - zeaxanthin
N1 - Accession Number: 33468702; Trumbo, Paula R. 1; Email Address: paula.trumbo@fda.hhs.gov; Affiliations: 1: Division of Nutrition Programs and Labeling, U.S. Food and Drug Administration, College Park, MD, USA; Issue Info: Aug2008, Vol. 66 Issue 8, p459; Subject Term: Diet in disease; Subject Term: Chronic diseases -- Risk factors; Subject Term: Determinants (Mathematics); Subject Term: Elemental diet; Subject Term: Public health -- United States; Subject: United States; Author-Supplied Keyword: age-related eye diseases; Author-Supplied Keyword: anthocyanins; Author-Supplied Keyword: chronic disease; Author-Supplied Keyword: dietary reference intakes; Author-Supplied Keyword: lutein; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: zeaxanthin; Number of Pages: 6p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1753-4887.2008.00077.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105698796
T1 - Challenges with using chronic disease endpoints in setting dietary reference intakes.
AU - Trumbo PR
Y1 - 2008/08//
N1 - Accession Number: 105698796. Language: English. Entry Date: 20081128. Revision Date: 20150820. Publication Type: Journal Article; review; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 0376405.
KW - Chronic Disease -- Prevention and Control
KW - Dietary Reference Intakes
KW - Adolescence
KW - Adult
KW - Child
KW - Chronic Disease -- Risk Factors
KW - Decision Making -- Methods
KW - Macronutrients
KW - Micronutrients
KW - Nutrition Disorders -- Prevention and Control
KW - Nutritional Requirements
SP - 459
EP - 464
JO - Nutrition Reviews
JF - Nutrition Reviews
JA - NUTR REV
VL - 66
IS - 8
PB - Oxford University Press / USA
SN - 0029-6643
AD - Division of Nutrition Programs and Labeling, US Food and Drug Administration, College Park, MD, USA
U2 - PMID: 18667007.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105698796&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Cope, Judith U.
AU - Morrison, Audrey E.
T1 - In Reply.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/08//
VL - 122
IS - 2
M3 - Letter
SP - 474
EP - 474
SN - 00314005
AB - A response by Judith U. Cope, Audrey E. Morrison, and Joy Samuels-Reid to a letter to the editor about their article on the use of infusion-pump technology by adolescent patients in the previous issue is presented.
KW - LETTERS to the editor
KW - INSULIN pumps
N1 - Accession Number: 34140535; Cope, Judith U. 1 Morrison, Audrey E. 2; Affiliation: 1: Division of Postmarket Surveillance, Office of Surveillance and Biometrics 2: Division of Anesthesiology, General Hospital, Infection Control and Dental Devices, Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20850; Source Info: Aug2008, Vol. 122 Issue 2, p474; Subject Term: LETTERS to the editor; Subject Term: INSULIN pumps; Number of Pages: 1/4p; Document Type: Letter
L3 - 10.1542/peds.2008-1566
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Agarwal, Vikas
AU - Nazzal, Sami
AU - Khan, Mansoor A.
T1 - Optimization and In Vivo Evaluation of an Oral Dual Controlled-Release Tablet Dosage Form of Insulin and Duck Ovomucoid.
JO - Pharmaceutical Development & Technology
JF - Pharmaceutical Development & Technology
Y1 - 2008/08//
VL - 13
IS - 4
M3 - Article
SP - 291
EP - 298
PB - Taylor & Francis Ltd
SN - 10837450
AB - The objectives of the present study were to (1) optimize the release rate of insulin from compressed microparticulates and (2) compare the in vivo hypoglycemic effect of optimized insulin microparticulates with compressed enzyme inhibitor (duck ovomucoid) and without inhibitor. A 3-factor, 15-run Box Behnken design was used to construct polynomial models correlating the dependent and independent variables. Independent processing variables were rate of addition of the alcoholic Eudragit© L100 dispersion, volume of the antisolvent, and compression pressure. Responses were cumulative percent of insulin released from 1-6 hours. Insulin and ovomucoid release was simultaneously analyzed by high-performance liquid chromatography. They demonstrated variable release rates, which were optimized to the Higuchi's square root of time model to release the insulin and the inhibitor over 6 hours. The relationship between dissolution profiles and process parameters were demonstrated by contour and response surface plots. In vivo hypoglycemic effect was evaluated in rabbits in a 3-way crossover design. Cocompressed microparticulates of insulin and duck ovomucoid displayed a 3.2-fold greater hypoglycemic effect when compared with a similar preparation without ovomucoid. This study demonstrated the potential benefits of dosage forms with dual controlled-release mechanisms for both the protein and enzyme inhibitor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Development & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL optimization
KW - INSULIN
KW - HORMONES
KW - DUCKS
KW - OVOMUCOID
KW - EGGS
KW - controlled release
KW - dissolution
KW - drug delivery
KW - optimization
KW - solid dispersion
KW - tablet dosage form
N1 - Accession Number: 33263468; Agarwal, Vikas 1; Email Address: vikas.agarwal@cimalabs.com; Nazzal, Sami 2; Khan, Mansoor A. 3; Affiliations: 1: Texas Tech University Health Sciences Center, Amarillo, TX Currently at CIMA, Brooklyn Park, MN; 2: Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA; 3: Food and Drug Administration, Division of Product Quality Research, Silver Spring, MD; Issue Info: Aug2008, Vol. 13 Issue 4, p291; Thesaurus Term: MATHEMATICAL optimization; Subject Term: INSULIN; Subject Term: HORMONES; Subject Term: DUCKS; Subject Term: OVOMUCOID; Subject Term: EGGS; Author-Supplied Keyword: controlled release; Author-Supplied Keyword: dissolution; Author-Supplied Keyword: drug delivery; Author-Supplied Keyword: optimization; Author-Supplied Keyword: solid dispersion; Author-Supplied Keyword: tablet dosage form; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112399 All other poultry production; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/10837450802089123
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Frueh, Felix W.
AU - Amur, Shashi
AU - Mummaneni, Padmaja
AU - Epstein, Robert S.
AU - Aubert, Ronald E.
AU - DeLuca, Teresa M.
AU - Verbrugge, Robert R.
AU - Burckart, Gilbert J.
AU - Lesko, Lawrence J.
T1 - Pharmacogenomic Biomarker Information in Drug Labels Approved by the United States Food and Drug Administration: Prevalence of Related Drug Use.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2008/08//
VL - 28
IS - 8
M3 - Article
SP - 992
EP - 998
SN - 02770008
AB - Study Objectives. To review the labels of United States Food and Drug Administration (FDA)-approved drugs to identify those that contain pharmacogenomic biomarker information, and to collect prevalence information on the use of those drugs for which pharmacogenomic information is included in the drug labeling. Design. Retrospective analysis. Data Sources. The Physicians' Desk Reference Web site, Drugs@FDA Web site, and manufacturers' Web sites were used to identify drug labels containing pharmacogenomic information, and the prescription claims database of a large pharmacy benefits manager (insuring > 55 million individuals in the United States) was used to obtain drug utilization data. Measurements and Main Results. Pharmacogenomic biomarkers were defined, FDA-approved drug labels containing this information were identified, and utilization of these drugs was determined. Of 1200 drug labels reviewed for the years 1945-2005, 121 drug labels contained pharmacogenomic information based on a key word search and follow-up screening. Of those, 69 labels referred to human genomic biomarkers, and 52 referred to microbial genomic biomarkers. Of the labels referring to human biomarkers, 43 (62%) pertained to polymorphisms in cytochrome P450 (CYP) enzyme metabolism, with CYP2D6 being most common. Of 36.1 million patients whose prescriptions were processed by a large pharmacy benefits manager in 2006, about 8.8 million (24.3%) received one or more drugs with human genomic biomarker information in the drug label. Conclusion. Nearly one fourth of all outpatients received one or more drugs that have pharmacogenomic information in the label for that drug. The incorporation and appropriate use of pharmacogenomic information in drug labels should be tested for its ability to improve drug use and safety in the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - LABELS
KW - DRUG utilization
KW - HUMAN genome
KW - CYTOCHROME P-450
KW - DRUGS -- Safety measures
KW - UNITED States
KW - biomarkers
KW - drug labels
KW - FDA
KW - pharmacogenomics
KW - pharmacy benefits manager
KW - U.S. Food and Drug Administration
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 33884137; Frueh, Felix W. 1 Amur, Shashi 1 Mummaneni, Padmaja 1 Epstein, Robert S. 2 Aubert, Ronald E. 2 DeLuca, Teresa M. 2 Verbrugge, Robert R. 2 Burckart, Gilbert J. 1; Email Address: gilbert.burckart@fda.hhs.gov Lesko, Lawrence J. 1; Affiliation: 1: Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration (FDA), Silver Spring, Maryland 2: Medco Health Solutions, Inc., Franklin Lakes, New Jersey; Source Info: Aug2008, Vol. 28 Issue 8, p992; Subject Term: BIOCHEMICAL markers; Subject Term: LABELS; Subject Term: DRUG utilization; Subject Term: HUMAN genome; Subject Term: CYTOCHROME P-450; Subject Term: DRUGS -- Safety measures; Subject Term: UNITED States; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: drug labels; Author-Supplied Keyword: FDA; Author-Supplied Keyword: pharmacogenomics; Author-Supplied Keyword: pharmacy benefits manager; Author-Supplied Keyword: U.S. Food and Drug Administration; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 323111 Commercial Printing (except Screen and Books); NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Young Joo
AU - Ryu, Heui-Young
AU - Kim, Hyun-Kyung
AU - Min, Chung Sik
AU - Lee, Jin Hee
AU - Kim, Eunhee
AU - Nam, Bong Hyun
AU - Park, Joo Hong
AU - Jung, Jin Young
AU - Jang, Dong Deuk
AU - Park, Eun Young
AU - Lee, Kwan-Hee
AU - Ma, Jin-Young
AU - Won, Hey-Sung
AU - Im, Moon-Whan
AU - Leem, Jong-Han
AU - Hong, Yun-Chul
AU - Yoon, Hae-Seong
T1 - Maternal and fetal exposure to bisphenol A in Korea
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2008/08//
VL - 25
IS - 4
M3 - Article
SP - 413
EP - 419
SN - 08906238
AB - Abstract: Bisphenol A (BPA) is a well-known endocrine disrupter used widely. Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy in Korea. This study purposed to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels to BPA in Korean pregnant women and their fetuses. Maternal blood and umbilical cord blood were collected from 300 subjects, and total BPA levels were measured. Blood BPA concentrations ranged from non-detectable to 66.48μg/L in pregnant women and from non-detectable to 8.86μg/L in umbilical cords. Serum BPA levels in most pregnant women were higher than in corresponding fetal umbilical cords and a positive correlation was found between in maternal and fetal BPA concentrations (p <0.05). [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREGNANCY
KW - REPRODUCTION
KW - BLOOD plasma
KW - KOREA
KW - Biomonitoring
KW - Bisphenol A
KW - Fetus
KW - Human exposure
KW - Korea
KW - Maternal serum
KW - Pregnant woman
KW - Umbilical cord blood
N1 - Accession Number: 33343657; Lee, Young Joo 1 Ryu, Heui-Young 1 Kim, Hyun-Kyung 1 Min, Chung Sik 1 Lee, Jin Hee 1 Kim, Eunhee 1 Nam, Bong Hyun 1 Park, Joo Hong 1 Jung, Jin Young 1 Jang, Dong Deuk 1 Park, Eun Young 2 Lee, Kwan-Hee 3 Ma, Jin-Young 4 Won, Hey-Sung 4 Im, Moon-Whan 5 Leem, Jong-Han 3 Hong, Yun-Chul 2 Yoon, Hae-Seong 1; Email Address: hsyoon0956@kfda.go.kr; Affiliation: 1: Human Exposure Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea 2: Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea 3: Department of Occupational and Environmental Medicine, Inha University Hospital, Inchun, Republic of Korea 4: Department of Obstetrics and Gynecology, Asan Medical Center, Seoul, Republic of Korea 5: Department of Obstetrics and Gynecology, Inha University Hospital, Inchun, Republic of Korea; Source Info: Aug2008, Vol. 25 Issue 4, p413; Subject Term: PREGNANCY; Subject Term: REPRODUCTION; Subject Term: BLOOD plasma; Subject Term: KOREA; Author-Supplied Keyword: Biomonitoring; Author-Supplied Keyword: Bisphenol A; Author-Supplied Keyword: Fetus; Author-Supplied Keyword: Human exposure; Author-Supplied Keyword: Korea; Author-Supplied Keyword: Maternal serum; Author-Supplied Keyword: Pregnant woman; Author-Supplied Keyword: Umbilical cord blood; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.reprotox.2008.05.058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van DommeIen, L.
AU - Smismans, A.
AU - Goossens, V. J.
AU - Damoiseaux, J.
AU - Bruggeman, C. A.
AU - van TieI, F. H.
AU - Hoebe, C. J. P. A.
T1 - EvaIuation of a rapid one-step immunochromatographic test and two immunoenzymatic assays for the detection of anti-Treponema pallidum antibodies.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2008/08//
VL - 84
IS - 4
M3 - Article
SP - 292
EP - 296
SN - 13684973
AB - Background: The control of syphilis depends on screening of the population at risk and is usually performed using the Treponema pal/idum particle agglutination test (TPPA). Outside Europe the rapid plasma reagin test (RPR) or venereal disease research laboratory test is most often used for screening purposes. Because of the drawbacks in current diagnostic procedures, ie, long turnaround time, the need is felt for a rapid and simple test that can potentially be performed on whole blood.: Objective and study design: In this study a one-step immunochrornatographic test (Biorapid Syphilis) and two ELISA, the Bioelisa Syphilis 3.0 and ETI-Treponema Plus, were evaluated. Methods: Serum samples were collected between February 2000 and May 2006 at the University Hospital in Maastricht, The Netherlands. 145 TPPA-positive sera, confirmed by fluorescent treponemal antibody absorption (FTA-Abs, treponemal test) and/or RPR (non-treponemal) were included. Furthermore, 41 sera from healthy controls and 144 TPPA-negative sera from controls with underlying conditions that might interfere with T pallidum serology were collected. Results: The sensitivity and specificity of the Biorapid Syphilis, Bioelisa Syphilis 3.0 and ETI-Treponema Plus were 92% and 79%, 100% and 100% and 100% and 100%, respectively, with our selected sera. Conclusions: The performance of both ELISA was excellent in Our study and is favoured over the TPPA because of. its ability to be run on an automated system. The sensitivity and specificity of the Biorapid Syphilis were considered too low to implement the test in a hospital laboratory in a developed country but it might be useful in primary healthcare settings in developing countries. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Infections is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SYPHILIS
KW - TREPONEMA pallidum
KW - AGGLUTINATION tests
KW - IMMUNOGLOBULINS
KW - MEDICAL care
N1 - Accession Number: 34386261; van DommeIen, L. 1; Email Address: Lvdo@Imib.azm.nI Smismans, A. 1 Goossens, V. J. 1 Damoiseaux, J. 2 Bruggeman, C. A. 1 van TieI, F. H. 1 Hoebe, C. J. P. A. 1,3; Affiliation: 1: Microbiology, Maastricht Infection Centre, University Hospital Maastricht, Maastricht, The Netherlands 2: Department of Clinical and Experimental Immunology, University Hospital Maastricht, Maastricht, The Netherlands 3: Department ot Infectious Diseases, South Limburg Municipal Public Health Service, Heerlen, The Netherlands; Source Info: Aug2008, Vol. 84 Issue 4, p292; Subject Term: SYPHILIS; Subject Term: TREPONEMA pallidum; Subject Term: AGGLUTINATION tests; Subject Term: IMMUNOGLOBULINS; Subject Term: MEDICAL care; Number of Pages: 5p; Illustrations: 1 Color Photograph, 4 Charts; Document Type: Article
L3 - 10.1136/sti.2007.028746
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gray, Darryl T.
AU - Hollingworth, William
AU - Onwudiwe, Nneka
AU - Jarvik, Jeffrey G.
T1 - Costs and State-Specific Rates of Thoracic and Lumbar Vertebroplasty, 2001-2005.
JO - Spine (03622436)
JF - Spine (03622436)
Y1 - 2008/08//8/1/2008
VL - 33
IS - 17
M3 - Article
SP - 1905
EP - 1912
SN - 03622436
AB - The article highlights the results of a sequential cross-sectional analysis to document vertebroplasty rates and costs in the U.S. It shows that nationwide vertebroplasty volumes and inflation-adjusted charges doubled from 2001 to 2005 in this Medicare population. The article further shows that almost all cases involved fluoroscopic guidance and that procedures treating multiple vertebral levels were not uncommon.
KW - LUMBAR vertebrae
KW - MEDICAL care costs
KW - THORACIC vertebrae
KW - MEDICARE
KW - UNITED States
KW - costs
KW - health service research
KW - lumbar
KW - Medicare
KW - rates
KW - thoracic
KW - vertebroplasty
N1 - Accession Number: 34097569; Gray, Darryl T. 1; Email Address: darryl.gray@ahrq.hhs.gov Hollingworth, William 2 Onwudiwe, Nneka 1,3 Jarvik, Jeffrey G. 4; Affiliation: 1: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD 2: Department of Social Medicine, University of Bristol, Bristol, UK 3: PharmaceuticaI Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 4: Departments of Radiology, Neurosurgery and Health Services, University of Washington, Seattle, WA; Source Info: 8/1/2008, Vol. 33 Issue 17, p1905; Subject Term: LUMBAR vertebrae; Subject Term: MEDICAL care costs; Subject Term: THORACIC vertebrae; Subject Term: MEDICARE; Subject Term: UNITED States; Author-Supplied Keyword: costs; Author-Supplied Keyword: health service research; Author-Supplied Keyword: lumbar; Author-Supplied Keyword: Medicare; Author-Supplied Keyword: rates; Author-Supplied Keyword: thoracic; Author-Supplied Keyword: vertebroplasty; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs, 2 Maps; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105549256
T1 - Costs and state-specific rates of thoracic and lumbar vertebroplasty, 2001-2005.
AU - Gray DT
AU - Hollingworth W
AU - Onwudiwe N
AU - Jarvik JG
AU - Gray, Darryl T
AU - Hollingworth, William
AU - Onwudiwe, Nneka
AU - Jarvik, Jeffrey G
Y1 - 2008/08//8/1/2008
N1 - Accession Number: 105549256. Language: English. Entry Date: 20090220. Revision Date: 20161115. Publication Type: journal article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Physical Therapy. Grant Information: P60 AR48093/AR/NIAMS NIH HHS/United States. NLM UID: 7610646.
KW - Costs and Cost Analysis
KW - Health Care Costs
KW - Kyphoplasty -- Economics
KW - Spinal Fractures -- Surgery
KW - Billing and Claims
KW - Cross Sectional Studies
KW - Current Procedural Terminology
KW - Data Analysis Software
KW - Data Collection Methods
KW - Diagnostic Imaging -- Economics
KW - Funding Source
KW - Medicare
KW - Prospective Studies
KW - Human
SP - 1905
EP - 1912
JO - Spine (03622436)
JF - Spine (03622436)
JA - SPINE
VL - 33
IS - 17
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Study Design: Sequential cross-sectional analysis.Objective: To document vertebroplasty rates and costs.Summary Of Background Data: Little is known about interstate variation in rates or about nation-wide costs associated with the growing use of percutaneous vertebroplasty.Methods: Using specific CPT-4 billing codes, we reviewed aggregate Medicare Part B fee-for-service claims data (cross-stratified by physician specialty and treatment setting) on thoracolumbar vertebroplasties performed from 2001-2005. Vertebroplasty rates for individual states were expressed per 100,000 Part B fee-for-service enrollees. Nation-wide facility and physician charges (combining expected contributions from all sources) allowed by Medicare for vertebroplasties and associated imaging guidance procedures were applied to observed vertebroplasty volumes. These charges (reflecting direct medical costs from an all-payer perspective) were expressed in 2005 dollars using the Producer Price Index.Results: Vertebroplasty rates for individual states rose but varied considerably, ranging from 0.0 to 515.6/100,000 Medicare Part B fee-for-service enrollees in 2001 (median state rate = 35.4), and from 9.8 to 849.5 in 2005 (median state rate = 75.0). On average, 1.3 vertebral levels were treated per procedure, varying by treatment site and physician specialty. Fluoroscopic rather than computed tomography guidance was used in 98.7% of cases. Total nation-wide inflation-adjusted charges rose from $76.0 million for 14,142 cases performed in 2001 to $152.3 million for 29,090 cases in 2005. While vertebroplasty was predominantly an outpatient procedure, inpatient cases generated most of the charges. Increasing volumes and costs were associated with cases performed in ambulatory surgery centers and physicians' offices.Conclusion: Nation-wide vertebroplasty volumes and inflation-adjusted charges doubled from 2001 to 2005 in this Medicare population. Procedure rates varied considerablyby state. Almost all cases involved fluoroscopic guidance; procedures treating multiple vertebral levels were not uncommon. Procedures performed in free-standing facilities are of growing importance. Given the issues surrounding appropriate vertebroplasty use, future practice patterns and outcomes should be closely tracked.
SN - 0362-2436
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA
AD - Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. darryl.gray@ahrq.hhs.gov
U2 - PMID: 18622357.
DO - 10.1097/BRS.0b013e31817bb0a4
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Kerlin, Roy
AU - Hutto, David
AU - Silverman, Lee
AU - Francke-Carroll, Sabine
AU - Vahle, John
T1 - Regulatory Forum for Toxicologic Pathology: An Update.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/08//
VL - 36
IS - 5
M3 - Editorial
SP - 760
EP - 760
SN - 01926233
AB - The authors present an update on the Regulatory Forum of "Toxicologic Pathology." They cite several reasons for initiating the forum, including the effort of retired Editor-in-Chief Jim Klaunig to look for ways to increase the impact, citation index and readership of this journal. According to the authors, they have decided to develop a committee to drive and ensure the success of the initiative. They encourage members of the Society of Toxicologic Pathology (STP) to suggest future forum content or volunteer.
KW - Forums (Discussion & debate)
KW - Committees
KW - Associations, institutions, etc. -- Membership
KW - Klaunig, Jim
N1 - Accession Number: 36557706; Kerlin, Roy 1; Email Address: roy.1.kerlin@pfizer.com; Hutto, David 2; Silverman, Lee 3; Francke-Carroll, Sabine 4; Vahle, John 5; Affiliations: 1: Drug Safety Research and Development, Pfizer Global Research and Development MS 8274-1210, Groton, Connecticut, USA; 2: Comparative Pathology, Biogen Idec, Inc., Cambridge, Massachusetts, USA; 3: Drug Safety Evaluation Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA; 4: Office for Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA; 5: Lilly Research Laboratories, Greenfield, Indiana, USA; Issue Info: 2008, Vol. 36 Issue 5, p760; Subject Term: Forums (Discussion & debate); Subject Term: Committees; Subject Term: Associations, institutions, etc. -- Membership; People: Klaunig, Jim; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1177/0192623308322009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36557706&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Abraham, Ann
AU - Plakas, Steven M.
AU - Flewelling, Leanne J.
AU - El Said, Kathleen R.
AU - Jester, Edward L.E.
AU - Granade, Hudson R.
AU - White, Kevin D.
AU - Dickey, Robert W.
T1 - Biomarkers of Neurotoxic Shellfish Poisoning
JO - Toxicon
JF - Toxicon
Y1 - 2008/08//
VL - 52
IS - 2
M3 - Article
SP - 237
EP - 245
SN - 00410101
AB - Abstract: Urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) were examined for biomarkers of brevetoxin intoxication. Brevetoxins were concentrated from urine by using solid-phase extraction (SPE), and analyzed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Urine extracts were fractionated by LC, and fractions analyzed for brevetoxins by ELISA. In subsequent LC-MS/MS analyses, several brevetoxin metabolites of B-type backbone were identified, with elution profiles consistent with those of ELISA. The more abundant brevetoxin metabolites in urine were characterized structurally by LC-MS/MS. With the exception of BTX-3, brevetoxin metabolites in urine differed from those found in shellfish and in shellfish meal remnants. Proposed structures of these major urinary metabolites are methylsulfoxy BTX-3, 27-epoxy BTX-3, and reduced BTX-B5. BTX-3 was found in all specimens examined. BTX-3 concentrations in urine, as determined by LC-MS/MS, correlated well with composite toxin measurements by ELISA (r 2 =0.96). BTX-3 is a useful biomarker for confirmation of clinical diagnosis of NSP. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXICOLOGY
KW - BIOCHEMICAL markers
KW - SHELLFISH
KW - CHROMATOGRAPHIC analysis
KW - Biomarkers
KW - Brevetoxins
KW - Neurotoxic shellfish poisoning
N1 - Accession Number: 33992567; Abraham, Ann 1; Email Address: ann.abraham@fda.hhs.gov Plakas, Steven M. 1 Flewelling, Leanne J. 2 El Said, Kathleen R. 1 Jester, Edward L.E. 1 Granade, Hudson R. 1 White, Kevin D. 3 Dickey, Robert W. 1; Affiliation: 1: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA 2: Florida Fish and Wildlife Conservation Commission, Fish and Wildlife Research Institute, St. Petersburg, FL 33701, USA 3: Spectroscopy and Mass Spectrometry Branch, U.S. Food and Drug Administration, College Park, MD 20740, USA; Source Info: Aug2008, Vol. 52 Issue 2, p237; Subject Term: NEUROTOXICOLOGY; Subject Term: BIOCHEMICAL markers; Subject Term: SHELLFISH; Subject Term: CHROMATOGRAPHIC analysis; Author-Supplied Keyword: Biomarkers; Author-Supplied Keyword: Brevetoxins; Author-Supplied Keyword: Neurotoxic shellfish poisoning; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.toxicon.2008.04.175
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33992567&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-10134-008
AN - 2008-10134-008
AU - Herman-Stahl, Mindy A.
AU - Ashley, Olivia Silber
AU - Penne, Michael A.
AU - Bauman, Karl E.
AU - Williams, Jason
AU - Sanchez, Rebecca P.
AU - Loomis, Kellie M.
AU - Williams, Megan S.
AU - Gfroerer, Joseph C.
T1 - Moderation and mediation in the relationship between mothers' or fathers' serious psychological distress and adolescent substance use: Findings from a national sample.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2008/08//
VL - 43
IS - 2
SP - 141
EP - 150
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Ashley, Olivia Silber, RTI International, Risk Behavior and Family Research Program, 3040 Cornwallis Road, Research Triangle Park, NC, US, 27709
N1 - Accession Number: 2008-10134-008. PMID: 18639787 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Herman-Stahl, Mindy A.; RTI International, Research Triangle Park, NC, US. Release Date: 20080825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Distress; Drug Abuse; Parent Child Relations; Psychosocial Development. Minor Descriptor: Fathers; Mothers. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: K6 Scale of Non-Specific Psychological Distress; National Health Interview Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Aug, 2008.
AB - Purpose: This study estimated percentages of adolescents living with a mother or father with serious psychological distress (SPD), and examined moderation and mediation of the relationships between mother or father SPD and adolescent substance use. Methods: We analyzed data from nationally representative samples of adolescents interviewed with their mothers (n = 4734) and fathers (n = 3176) in the combined 2002 and 2003 National Surveys on Drug Use and Health (NSDUHs). Results: An estimated 4.1% of adolescents living with their father had a father with SPD during the past year, and 11.5% of adolescents living with their mother had a mother with SPD during this time period. A positive association was found between mothers' SPD and adolescent binge drinking (OR = 1.49, 95% CI = 1.01-2.21), but no association was found between fathers' SPD and adolescent binge drinking. Mothers' SPD was associated with increased risk of binge drinking among adolescents aged 14-15 years (OR = 2.52, 95% CI = 1.38-4.60), and fathers' SPD was associated with lowered risk of binge drinking among black adolescents (OR = .08, 95% CI = .01-.79). A positive association was found between mothers' SPD and adolescent illicit drug use (OR = 1.55, 95% CI = 1.08-2.23), but no association was found between fathers' SPD and adolescent illicit drug use. Mothers' SPD was associated with increased risk of illicit drug use among female adolescents (OR = 2.14, 95% CI = 1.24-3.70) and among adolescents of white ethnicity (OR = 1.78, 95% CI = 1.19, 2.68). Parental involvement partially mediated the relationship between mothers' SPD and daughters' illicit drug use; mothers' SPD was associated with lower levels of parental involvement, which in turn were associated with an increased probability of daughters' illicit drug use. Conclusions: Overall, parents' SPD is associated differentially with adolescent substance use depending on the gender of parent and adolescent, adolescent age, race/ethnicity, and substance used. Parental involvement appears to be one mechanism through which mothers' SPD influences daughters' illicit drug use. Future research should further consider the interindividual effects of parents' SPD and associated parenting behaviors on adolescent risk behaviors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - relationship moderation
KW - relationship mediation
KW - mothers
KW - fathers
KW - serious psychological distress
KW - adolescent substance use
KW - 2008
KW - Adolescent Attitudes
KW - Distress
KW - Drug Abuse
KW - Parent Child Relations
KW - Psychosocial Development
KW - Fathers
KW - Mothers
KW - 2008
DO - 10.1016/j.jadohealth.2008.01.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-10134-008&site=ehost-live&scope=site
UR - ORCID: 0000-0002-3804-2594
UR -
UR - osilber@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-07073-004
AN - 2008-07073-004
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - Siahpush, Mohammad
AU - van Dyck, Peter C.
T1 - Independent and joint effects of socioeconomic, behavioral, and neighborhood characteristics on physical inactivity and activity levels among U.S. children and adolescents.
JF - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JO - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JA - J Community Health
Y1 - 2008/08//
VL - 33
IS - 4
SP - 206
EP - 216
CY - Germany
PB - Springer
SN - 0094-5145
SN - 1573-3610
AD - Singh, Gopal K., Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2008-07073-004. PMID: 18373183 Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Behavior; Neighborhoods; Physical Activity; Socioeconomic Status. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug, 2008.
AB - This study examines the independent and joint associations between several socioeconomic and behavioral characteristics and physical activity (PA) and inactivity prevalence among 68,288 US children aged 6-17 years. The 2003 National Survey of Children's Health was used to estimate PA prevalence. Multivariate logistic regression was used to estimate odds of activity and inactivity and adjusted prevalence, while least squares regression was used to model mean number of days of physical inactivity (PIA) in past month. The prevalence of PA varied substantially by socioeconomic and behavioral characteristics, with older, female, non-English speaking, and metropolitan children and those with lower socioeconomic status (SES) and neighborhood social capital having higher inactivity and lower activity levels. Children who watched television ≥3 h/day had 60% higher adjusted odds of PIA and 30% lower odds of PA than those who watched television <3 h/day. Children experiencing inadequate sleep during the entire week had 55% higher odds of PIA and 29% lower odds of PA than those who experienced ≥5 nights of adequate sleep during the week. Children whose both parents were physically inactive had 147% higher odds of PIA and 46% lower odds of PA than children whose parents were both physically active. Differentials in PIA by ethnicity, SES, television viewing, and parental inactivity were greater for younger than for older children. Subgroups such as older, female adolescents, children from socially disadvantaged households and neighborhoods, and those in metropolitan areas should be targeted for the promotion of regular physical activity and reduced television viewing time. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - physical activity
KW - socioeconomic status
KW - neighborhood characteristics
KW - behavioral characteristics
KW - 2008
KW - Activity Level
KW - Behavior
KW - Neighborhoods
KW - Physical Activity
KW - Socioeconomic Status
KW - 2008
DO - 10.1007/s10900-008-9094-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-07073-004&site=ehost-live&scope=site
UR - gsingh@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11379-003
AN - 2008-11379-003
AU - Neal, Richard D.
AU - Cannings-John, Rebecca
AU - Hood, Kerenza
AU - Sowden, Jonathan
AU - Lawrence, Helen
AU - Jones, Claire
AU - Jones, Julie
T1 - Excision of malignant melanomas in North Wales: Effect of location and surgeon on time to diagnosis and quality of excision.
JF - Family Practice
JO - Family Practice
JA - Fam Pract
Y1 - 2008/08//
VL - 25
IS - 4
SP - 221
EP - 227
CY - United Kingdom
PB - Oxford University Press
SN - 0263-2136
SN - 1460-2229
AD - Neal, Richard D., Department of Primary Care and Public Health, North Wales Clinical School, School of Medicine, Cardiff University, Wrexham Technology Park, Wrexham, United Kingdom, LL13 7YP
N1 - Accession Number: 2008-11379-003. PMID: 18573803 Partial author list: First Author & Affiliation: Neal, Richard D.; Department of Primary Care and Public Health, North Wales Clinical School, School of Medicine, Cardiff University, Wrexham, United Kingdom. Release Date: 20080922. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Hood, Kerenza. Major Descriptor: Diagnosis; Neoplasms; Quality of Care; Surgery. Minor Descriptor: Melanoma. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: United Kingdom. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug, 2008.
AB - Background: The epidemiology of melanoma is changing and its current management is variable, with some lesions being removed in general practice. We aimed to determine the quality of excision and time to diagnosis relating to the excising surgeon and the place of excision. Method: Analysis of data from the North Wales Melanoma Database. Results: In total, 578 cases were diagnosed 1993-2001. There was a gender difference with anatomical location, with 107 (65%) males with lesions on their trunk compared to 57 (35%) females. Median Breslow thickness was 1.10 mm (range 0.05-16.0 mm). Ninety-five (16%) lesions were removed in general practice, of which 49 (52%) were referred on to hospital. In total, 266 (61%) lesions were excised with 'adequate' margins and 170 (39%) excised with margins narrower than the guidelines. General practice excisions were from a younger group than hospital excisions. There were no differences in quality of excision between general practice and hospital excisions. Time to diagnosis was shorter overall for general practice excisions than hospital excisions (median 12 versus 41 days, P < 0.001). Conclusion: These findings are of policy importance in that there is no evidence from this study that general practice excisions are managed poorly or have a worse prognosis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - malignant melanomas
KW - quality of excision
KW - diagnosis
KW - 2008
KW - Diagnosis
KW - Neoplasms
KW - Quality of Care
KW - Surgery
KW - Melanoma
KW - 2008
U1 - Sponsor: Wales Office for Research and Development, Wales. Recipients: Hood, Kerenza
DO - 10.1093/fampra/cmn036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11379-003&site=ehost-live&scope=site
UR - nealrd@cf.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11666-006
AN - 2008-11666-006
AU - Bellamy, Nikki D.
AU - Wang, Min Qi
AU - Matthew, Resa F.
AU - Leitao, Marion P.
AU - Agee, Rená A.
AU - Yan, Alice F.
T1 - Structural model analysis of HIV risk behaviors among sexually active minority adolescents.
JF - Journal of the National Medical Association
JO - Journal of the National Medical Association
JA - J Natl Med Assoc
Y1 - 2008/08//
VL - 100
IS - 8
SP - 914
EP - 924
CY - US
PB - National Medical Assn
SN - 0027-9684
SN - 1943-4693
AD - Bellamy, Nikki D., Substance Abuse and Mental Health Services Administration, Center tor Mental Health Services, Prevention, Traumatic Stress and Special Programs, 1 Choke Cherry Road, Room 6-1003, Rockville, MD, US, 20857
N1 - Accession Number: 2008-11666-006. PMID: 18717142 Partial author list: First Author & Affiliation: Bellamy, Nikki D.; Substance Abuse and Mental Health Services Administration, Center tor Mental Health Services, Prevention, Traumatic Stress and Special Programs, Rockville, MD, US. Other Publishers: Elsevier Science. Release Date: 20090330. Correction Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Evaluation; HIV; Minority Groups; Risk Factors; Sexual Partners. Minor Descriptor: Adolescent Development; Blacks; Latinos/Latinas. Classification: Immunological Disorders (3291). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Youth Baseline Survey; Moos Family Environment Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug, 2008.
AB - Contents of this article are solely the responsibility of the authors and do not necessarily reflect the opinions, official policy or position of the U.S. Department of Health and Human Services, the Substance Abuse and Mental Health Services Administration or Centers for Mental Health Services and Substance Abuse Prevention. Objective: To evaluate an HIV risk profile in sexually active black and Hispanic adolescents using a structural equation model (SEM). Method: Grantees from 15 states and Washington, DC, were selected to participate in the study. Black and Hispanic adolescents (N = 2,371) who completed the baseline instrument were required to have experienced vaginal, oral or anal sex in order to be included in this study. Total minority youths who self-reported as black but not Hispanic were n = 1,455 and for Hispanic n = 916. Results: The hypothesized model fit moderately well (CFI = 0.940, TLI = 0.928, RMSEA = 0.039). The key significant direct effect was found (P < 0.05) for higher alcohol, tobacco and other drug use related to nonuse of condoms, more sex partners and use of substances before sex. Conclusion: Current findings underscore the need to incorporate culturally sensitive strategies in developing programs for minority youth. However, given that minority group members often report greater experiences of discrimination than whites, future research in this area should also include an examination of the role of other stressors such as racial disparities and their potential cumulative impact on minority youth and their risks for alcohol, tobacco and other drug use and HIV. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - HIV risk behaviors
KW - evaluation
KW - sexually active minority adolescents
KW - minority group members
KW - sex partners
KW - Black & Hispanic adolescents
KW - 2008
KW - Evaluation
KW - HIV
KW - Minority Groups
KW - Risk Factors
KW - Sexual Partners
KW - Adolescent Development
KW - Blacks
KW - Latinos/Latinas
KW - 2008
U1 - Sponsor: Center for Substance Abuse Prevention. Grant: 277-00-6207. Other Details: Macro International, inc.. Recipients: No recipient indicated
DO - 10.1016/S0027-9684(15)31405-X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11666-006&site=ehost-live&scope=site
UR - nikki.bellamy@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-08643-003
AN - 2008-08643-003
AU - Hahn, Susan E.
AU - Murphy, Lawrence R.
T1 - A short scale for measuring safety climate.
JF - Safety Science
JO - Safety Science
JA - Saf Sci
Y1 - 2008/08//
VL - 46
IS - 7
SP - 1047
EP - 1066
CY - Netherlands
PB - Elsevier Science
SN - 0925-7535
AD - Hahn, Susan E., Department of Psychology, Miami University, Hamilton, 1601 University Boulevard, Hamilton, OH, US, 45011-3399
N1 - Accession Number: 2008-08643-003. Other Journal Title: Journal of Occupational Accidents. Partial author list: First Author & Affiliation: Hahn, Susan E.; Department of Psychology, Miami University, Hamilton, Hamilton, OH, US. Release Date: 20090831. Correction Date: 20151228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Industrial Accidents; Occupational Safety; Organizational Climate; Psychometrics. Minor Descriptor: Test Validity. Classification: Occupational & Employment Testing (2228); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Aug, 2008.
AB - A 6-item measure that assesses global work safety climate was validated using multiple samples each from a hospital and a nuclear energy population. Across all 14 samples the 6-item measure had acceptable internal consistency. The measure was associated with better adherence to safe work practices, reduced exposure to environmental stressors, the presence of more safety policies and procedures, a positive general organizational climate, and decreased accidents. As evidence for discriminant validity, safety climate was unrelated to most demographic measures and had relatively small relationships with sleeping problems and negative mood. Evidence suggests that this measure is a reliable and valid way to assess global safety climate. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - safety climate
KW - organizational climate
KW - psychometrics
KW - test validity
KW - accidents
KW - 2008
KW - Industrial Accidents
KW - Occupational Safety
KW - Organizational Climate
KW - Psychometrics
KW - Test Validity
KW - 2008
DO - 10.1016/j.ssci.2007.06.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08643-003&site=ehost-live&scope=site
UR - lrm2@cdc.gov
UR - hahns@muohio.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11021-017
AN - 2008-11021-017
AU - Schrader, Steven M.
AU - Breitenstein, Michael J.
AU - Lowe, Brian D.
T1 - Cutting off the nose to save the penis.
JF - Journal of Sexual Medicine
JO - Journal of Sexual Medicine
JA - J Sex Med
Y1 - 2008/08//
VL - 5
IS - 8
SP - 1932
EP - 1940
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1743-6095
SN - 1743-6109
AD - Schrader, Steven M., NIOSH, C-23, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2008-11021-017. PMID: 18466268 Partial author list: First Author & Affiliation: Schrader, Steven M.; Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Other Publishers: Blackwell Publishing; Elsevier Science. Release Date: 20080929. Correction Date: 20160229. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Penis; Police Personnel; Sexual Function Disturbances; Somatosensory Disorders; Urogenital Disorders. Minor Descriptor: Human Factors Engineering; Intervention. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: International Index of Erectile Function Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Aug, 2008.
AB - Introduction: The average bicycle police officer spends 24 hours a week on his bicycle and previous studies have shown riding a bicycle with a traditional (nosed) saddle has been associated with urogenital paresthesia and sexual dysfunction. Aim: The objective of this study was to assess the effectiveness of the no-nose bicycle saddle as an ergonomic intervention and their acceptance among male bicycle police officers. Methods: Bicycle police officers from five U.S. metropolitan areas were recruited for this study. Officers completed: (i) the International Index of Erectile Function Questionnaire (IIEF); (ii) computerized pressure measurements at the points of contact on the bicycle; the handlebars, the pedals, and the saddle; (iii) one night of nocturnal Rigiscan® assessment; (iv) penile vibrotactile sensitivity threshold assessed by computerized biothesiometery. Officers selected a no-nose saddle for their bicycles and were asked to use the intervention saddle exclusively for 6 months, at which point they were retested. Main Outcome Measures: Perineal pressure, urogenital numbness, penile vibrotactile sensitivity threshold, erectile function as measure by International Index of Erectile Function Questionnaire (IIEF) and Rigiscan. Results: After 6 months, 90 men were reassessed. Only three men had returned to a traditional saddle. The results are presented for those who used the no-nose saddle continuously for 6 months. There was a 66% reduction in saddle contact pressure in the perineal region (P < 0.001). There was a significant improvement in penis tactile sensation (P = 0.015). There was a significant improvement in erectile function assessed by IIEF (P = 0.015). There were no changes noted in the Rigiscan® measures. The number of men indicating they had not experienced urogential paresthesia while cycling for the preceding 6 months, rose from 27% to 82% using no-nose saddles. Conclusions: (i) With few exceptions, bicycle police officers were able to effectively use no-nose saddles in their police work. (ii) Use of no-nose saddles reduced most perineal pressure. (iii) Penile health improved after 6 month using no-nose saddles as measured by biothesiometry and IIEF. There was no improvement in Rigiscan® measure after 6 months of using no nose saddles, suggesting that a longer recovery time may be needed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - bicycle police officer
KW - urogenital paresthesia
KW - sexual dysfunction
KW - ergonomic intervention
KW - 2008
KW - Penis
KW - Police Personnel
KW - Sexual Function Disturbances
KW - Somatosensory Disorders
KW - Urogenital Disorders
KW - Human Factors Engineering
KW - Intervention
KW - 2008
DO - 10.1111/j.1743-6109.2008.00867.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11021-017&site=ehost-live&scope=site
UR - sms4@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-14984-001
AN - 2011-14984-001
AU - Brady, Linda S.
AU - Giffin, Robert B.
AU - Woodcock, Janet
AU - Cassell, Gail H.
AU - Holmes, Edward W.
T1 - Grand challenges for psychiatric drug discovery: A perspective.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2008/08//
VL - 33
IS - 9
SP - 2047
EP - 2047
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
N1 - Accession Number: 2011-14984-001. PMID: 18626470 Partial author list: First Author & Affiliation: Brady, Linda S.; Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, US. Release Date: 20110912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Drug Therapy; Neuroleptic Drugs; Schizophrenia. Minor Descriptor: Syndromes. Classification: Clinical Psychopharmacology (3340). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: Aug, 2008. Copyright Statement: All rights reserved. Nature Publishing Group. 2008.
AB - Comments on the article by W. T. Carpenter and J. I. Koenig (see record [rid]2011-14984-003[/rid]); P. J. Conn and B. L. Roth (see record [rid]2011-14984-002[/rid]) and S. J. Mathew et al. (see record [rid]2011-14984-004[/rid]). These three papers identify opportunities and challenges to translate advances in basic and clinical neuroscience into novel medications to treat mood and anxiety disorders and schizophrenia. Some common themes emerge from these papers. The authors identify the need to develop novel mechanism of action therapeutics based on validated molecular targets. The authors summarize the variable degree of predictive value that existing preclinical models have in assessing efficacy in the majority of psychiatric disorders. The authors suggest targeting core phenotypic domains of dysfunction within and across psychiatric disorders, such as cognitive deficits in schizophrenia, sleep disturbances in post-traumatic stress disorder, and suicide across multiple disorders. The papers cite significant opportunities as well as challenges for system-level approaches to facilitate the translation of basic discoveries into validated drug targets and new models of impaired domains of function. These opportunities have the potential to introduce innovation along the critical path for psychiatric drug discovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug development
KW - schizophrenia
KW - disease syndrome
KW - pharmacotherapeutics
KW - antipsychotic medications
KW - 2008
KW - Drug Therapy
KW - Neuroleptic Drugs
KW - Schizophrenia
KW - Syndromes
KW - 2008
DO - 10.1038/npp.2008.54
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-14984-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105693233
T1 - Overview of the conference 'Vitamin D and Health in the 21st Century: an Update'.
AU - Brannon PM
AU - Yetley EA
AU - Bailey RL
AU - Picciano MF
Y1 - 2008/08/02/Aug2008 Supplement
N1 - Accession Number: 105693233. Language: English. Entry Date: 20081121. Revision Date: 20150819. Publication Type: Journal Article; questions and answers. Supplement Title: Aug2008 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 0376027.
KW - Diet
KW - Dietary Supplementation
KW - Functional Status
KW - Health
KW - Vitamin D
KW - Bone Density
KW - Congresses and Conferences -- Maryland
KW - Dose-Response Relationship
KW - Maryland
KW - National Institutes of Health (U.S.)
KW - Research Priorities
KW - Sunlight
KW - United States
KW - Vitamin D -- Adverse Effects
SP - 483S
EP - 90S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 88
IS - 2(S)
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - We summarize the key findings, strength of the evidence, and research needs identified in the National Institutes of Health conference 'Vitamin D and Health in the 21st Century: an Update,' which was held in September 2007; a systematic evidence-based review; and a National Institutes of Health roundtable discussion held after the conference by scientists with relevant expertise. The evidence-based review addressed 5 questions on 25-hydroxyvitamin D [25(OH)D] and functional outcomes across the life cycle and response to exposure, bone health outcomes of supplementation, risks and benefits of sun exposure, and adverse outcomes. These questions also framed the conference and roundtable discussions. Researchers have made considerable progress in understanding the relation of 25(OH)D to bone health outcomes in the elderly and in postmenopausal women, but we know less about its impact on other stages of the life cycle and in racial and ethnic groups. Limitations of the existing data include the failure of many studies to control for important confounders [baseline 25(OH)D concentration, skin pigmentation, body mass index, compliance, etc], sparse data on key vulnerable populations (dark-skinned persons, reproducing women, infants, children, and adolescents), problems of accuracy and excessive variability in measuring 25(OH)D, lack of established relation of 25(OH)D with functional outcomes except in the elderly, and limited information on the effects of vitamin D independent of calcium, magnesium, and phosphate. Future research should determine and validate across the life cycle relevant functional outcomes for bone and other health factors as well as adverse outcomes for the biomarker of exposure, 25(OH)D, to enable assessment of the role of vitamin D status in health maintenance and disease prevention. © 2008 American Society for Nutrition
SN - 0002-9165
AD - Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, , Bethesda, MD 20892-7517
U2 - PMID: 18689388.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105693233&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105693249
T1 - Summary of roundtable discussion on vitamin D research needs.
AU - Brannon PM
AU - Yetley EA
AU - Bailey RL
AU - Picciano MF
Y1 - 2008/08/02/Aug2008 Supplement
N1 - Accession Number: 105693249. Language: English. Entry Date: 20081121. Revision Date: 20150819. Publication Type: Journal Article; questions and answers. Supplement Title: Aug2008 Supplement. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 0376027.
KW - Diet
KW - Dietary Supplementation
KW - Functional Status
KW - Health
KW - Vitamin D
KW - Accidental Falls -- Risk Factors
KW - Aged
KW - Biological Markers
KW - Bone Density
KW - Child
KW - Dose-Response Relationship
KW - Female
KW - Fractures
KW - Infant
KW - Lactation
KW - Male
KW - Postmenopause
KW - Pregnancy
KW - Research Priorities
KW - Sunlight
KW - Vitamin D -- Adverse Effects
KW - Vitamin D -- Blood
KW - Vitamin D -- Metabolism
SP - 587S
EP - 92S
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 88
IS - 2(S)
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - We summarize the discussions of a roundtable following the conference 'Vitamin D and Health in the 21st Century: an Update.' The roundtable participants offered additional information on vitamin D research needs from a critical, impartial, and interdisciplinary perspective. Although the group recognized the progress to date, they found that the available evidence on the relation of 25-hydroxyvitamin D, dietary intake, status, functional health, and adverse outcomes has significant limitations because most studies have been short term, have failed to consider important confounders such as baseline vitamin D status and body mass index, and did not study key populations. To meet these data gaps, the roundtable identified several overarching research needs: 1) long-term, high-quality dose-response studies with relevant outcomes, including bone health, other functional outcomes (such as immune function, autoimmune disorders, and chronic disease prevention), and adverse outcomes (such as hypercalcemia and hypercalcuria), especially in understudied population groups such as dark-skinned individuals, infants, adolescents, reproductive-aged women, and pregnant and lactating women; 2) further research to understand the relation of 25-hydroxyvitamin D threshold values to relevant functional outcomes in each life stage and in racial and ethnic groups; 3) further research to understand the metabolic partitioning, fate, and mobilization of key vitamin D metabolites at recommended and greater than recommended intakes to assess the availability of stored vitamin D, relative contributions of endogenously produced and dietary vitamin D, and impact of important confounders (such as body mass index) on vitamin D status; and 4) further research to define the maximal, long-term vitamin D intake to ensure safety for all humans. © 2008 American Society for Nutrition
SN - 0002-9165
AD - Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD
U2 - PMID: 18689407.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105693249&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Ross, Sharon A.
AU - Beland, Frederick A.
T1 - Differential expression of microRNAs during hepatocarcinogenesis induced by methyl deficiency in rats.
JO - Nutrition Reviews
JF - Nutrition Reviews
Y1 - 2008/08/02/Aug2008 Supplement
VL - 66
M3 - Article
SP - S33
EP - S35
SN - 00296643
AB - The article presents a study which examines the role of micro ribonucleic acid (miRNA) during hepatocarcinogenesis induced by methyl deficiency in rats. The study is characterized by prominent changes in expression of miRNA genes, specifically by inhibition of expression of tumor suppressor miRNAs which are responsible for maintaining the balance between cell proliferation and apoptosis. It is mentioned that downregulation of the miR-34a and upregulation of E2F3 may lead to a reduction of the cellular apoptotic program via inhibition of the p53-network. Moreover, miRNA expression may be an important causative factor in the development of hepatocellular carcinoma (HCC). Additionally, diagrams are presented to further analyze the study.
KW - RNA
KW - Carcinogenesis
KW - Apoptosis
KW - Antioncogenes
KW - Cell proliferation
KW - p53 antioncogene
KW - Gene expression
KW - Liver -- Cancer
KW - Rats as laboratory animals
N1 - Accession Number: 33468720; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov; Tryndyak, Volodymyr P. 1; Ross, Sharon A. 2; Beland, Frederick A. 1; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA; 2: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA; Issue Info: Aug2008 Supplement, Vol. 66, pS33; Thesaurus Term: RNA; Thesaurus Term: Carcinogenesis; Thesaurus Term: Apoptosis; Subject Term: Antioncogenes; Subject Term: Cell proliferation; Subject Term: p53 antioncogene; Subject Term: Gene expression; Subject Term: Liver -- Cancer; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 1p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1753-4887.2008.00064.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33468720&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lin, Kenneth
AU - Lipsitz, Robert
AU - Miller, Therese
AU - Janakiraman, Supriya
T1 - Benefits and Harms of Prostate-Specific Antigen Screening for Prostate Cancer: An Evidence Update for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2008/08/05/
VL - 149
IS - 3
M3 - Article
SP - 192
EP - 199
SN - 00034819
AB - Background: Prostate cancer is the most common nonskin cancer in men in the United States, and prostate cancer screening has increased in recent years. In 2002, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening for prostate cancer with prostate-specific antigen (PSA) testing. Purpose: To examine new evidence on benefits and harms of screening asymptomatic men for prostate cancer with PSA. Data Sources: English-language articles identified in PubMed and the Cochrane Library (search dates, January 2002 to July 2007), reference lists of retrieved articles, and expert suggestions. Study Selection: Randomized, controlled trials and meta-analyses of PSA screening and cross-sectional and cohort studies of screening harms and of the natural history of screening-detected cancer were selected to answer the following questions: Does screening for prostate cancer with PSA, as a single-threshold test or as a function of multiple tests over time, decrease morbidity or mortality? What are the magnitude and nature of harms associated with prostate cancer screening, other than overtreatment? What is the natural history of PSA-detected, nonpalpable, localized prostate cancer? Data Extraction: Studies were reviewed, abstracted, and rated for quality by using predefined U.S. Preventive Services Task Force criteria. Data Synthesis: No good-quality randomized, controlled trials of screening for prostate cancer have been completed. In 1 cross-sectional and 2 prospective cohort studies of fair to good quality, false-positive PSA screening results caused psychological adverse effects for up to 1 year after the test. The natural history of PSA-detected prostate cancer is poorly understood. Limitations: Few eligible studies were identified. Long-term adverse effects of false-positive PSA screening test results are unknown. Conclusion: Prostate-specific antigen screening is associated with psychological harms, and its potential benefits remain uncertain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE diseases
KW - MEN -- Diseases
KW - CANCER prevention
KW - PROSTATE-specific antigen
KW - MEDICAL screening
KW - UNITED States
N1 - Accession Number: 33942579; Lin, Kenneth 1; Email Address: kenneth.lin@ahrq.hhs.gov. Lipsitz, Robert 1 Miller, Therese 1 Janakiraman, Supriya 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 8/5/2008, Vol. 149 Issue 3, p192; Subject Term: PROSTATE diseases; Subject Term: MEN -- Diseases; Subject Term: CANCER prevention; Subject Term: PROSTATE-specific antigen; Subject Term: MEDICAL screening; Subject Term: UNITED States; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33942579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105647160
T1 - Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the U.S. Preventive Services Task Force.
AU - Lin K
AU - Lipsitz R
AU - Miller T
AU - Janakiraman S
Y1 - 2008/08/05/
N1 - Accession Number: 105647160. Corporate Author: U.S. Preventive Services Task Force. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; consumer/patient teaching materials; research; systematic review; tables/charts. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care. NLM UID: 0372351.
KW - Cancer Screening -- Adverse Effects
KW - Cancer Screening -- Standards
KW - Prostate-Specific Antigen -- Blood
KW - Prostatic Neoplasms -- Diagnosis
KW - Biopsy -- Adverse Effects
KW - Cancer Screening -- Psychosocial Factors
KW - False Positive Results
KW - Medical Practice, Evidence-Based
KW - Medline
KW - Physical Examination
KW - Practice Guidelines
KW - Prostatic Neoplasms -- Mortality
KW - Prostatic Neoplasms -- Therapy
KW - Risk Assessment
KW - Systematic Review
KW - United States Preventive Services Task Force
KW - Human
SP - 192
EP - 37
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 149
IS - 3
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Prostate cancer is the most common nonskin cancer in men in the United States, and prostate cancer screening has increased in recent years. In 2002, the U.S. Preventive Services Task Force concluded that evidence was insufficient to recommend for or against screening for prostate cancer with prostate-specific antigen (PSA) testing. PURPOSE: To examine new evidence on benefits and harms of screening asymptomatic men for prostate cancer with PSA. DATA SOURCES: English-language articles identified in PubMed and the Cochrane Library (search dates, January 2002 to July 2007), reference lists of retrieved articles, and expert suggestions. STUDY SELECTION: Randomized, controlled trials and meta-analyses of PSA screening and cross-sectional and cohort studies of screening harms and of the natural history of screening-detected cancer were selected to answer the following questions: Does screening for prostate cancer with PSA, as a single-threshold test or as a function of multiple tests over time, decrease morbidity or mortality? What are the magnitude and nature of harms associated with prostate cancer screening, other than overtreatment? What is the natural history of PSA-detected, nonpalpable, localized prostate cancer? DATA EXTRACTION: Studies were reviewed, abstracted, and rated for quality by using predefined U.S. Preventive Services Task Force criteria. DATA SYNTHESIS: No good-quality randomized, controlled trials of screening for prostate cancer have been completed. In 1 cross-sectional and 2 prospective cohort studies of fair to good quality, false-positive PSA screening results caused psychological adverse effects for up to 1 year after the test. The natural history of PSA-detected prostate cancer is poorly understood. LIMITATIONS: Few eligible studies were identified. Long-term adverse effects of false-positive PSA screening test results are unknown. CONCLUSION: Prostate-specific antigen screening is associated with psychological harms, and its potential benefits remain uncertain.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. kenneth.lin@ahrq.hhs.gov
U2 - PMID: 18678846.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105647160&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shuang Tang
AU - Bertke, Andrea S.
AU - Patel, Amita
AU - Wang, Kening
AU - Cohen, Jeffrey I.
AU - Krause, Philip R.
T1 - An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2008/08/05/
VL - 105
IS - 31
M3 - Article
SP - 10931
EP - 10936
SN - 00278424
AB - Latency-associated transcript (LAT) sequences regulate herpes simplex virus (HSV) latency and reactivation from sensory neurons. We found a HSV-2 LAT-related microRNA (miRNA) designated miR-I in transfected and infected cells in vitro and in acutely and latently infected ganglia of guinea pigs in vivo. miR-I is also expressed in human sacral dorsal root ganglia latently infected with HSV-2. miR-l is expressed under the LAT promoter in vivo in infected sensory ganglia. We also predicted and identified a HSV-1 LAT exon-2 viral miRNA in a location similar to miR-l, implying a conserved mechanism in these closely related viruses. In transfected and infected cells, miR-l reduces expression of ICP34.5, a key viral neurovirulence factor. We hypothesize that miR-l may modulate the outcome of viral infection in the peripheral nervous system by functioning as a molecular switch for ICP34.5 expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - DISEASES -- Risk factors
KW - GENOMES
KW - PHENOTYPE
KW - RNA
KW - SENSORY ganglia
KW - GENETIC code
KW - HSV
KW - human
KW - latency
KW - latency-associated transcript
KW - reactivation
N1 - Accession Number: 34081883; Shuang Tang 1 Bertke, Andrea S. 1 Patel, Amita 1 Wang, Kening 2 Cohen, Jeffrey I. 2 Krause, Philip R. 1; Email Address: philip.krause@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 2: Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892; Source Info: 8/5/2008, Vol. 105 Issue 31, p10931; Subject Term: HERPES simplex virus; Subject Term: DISEASES -- Risk factors; Subject Term: GENOMES; Subject Term: PHENOTYPE; Subject Term: RNA; Subject Term: SENSORY ganglia; Subject Term: GENETIC code; Author-Supplied Keyword: HSV; Author-Supplied Keyword: human; Author-Supplied Keyword: latency; Author-Supplied Keyword: latency-associated transcript; Author-Supplied Keyword: reactivation; Number of Pages: 6p; Illustrations: 4 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1073/pnas.0801845105
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shah, R.B.
AU - Bryant, A.
AU - Collier, J.
AU - Habib, M.J.
AU - Khan, M.A.
T1 - Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/08/06/
VL - 360
IS - 1/2
M3 - Article
SP - 77
EP - 82
SN - 03785173
AB - Abstract: A simple, sensitive, accurate, and robust stability indicating analytical method is presented for identification, separation, and quantitation of l-thyroxine and eight degradation impurities with an internal standard. The method was used in the presence of commonly used formulation excipients such as butylated hydroxyanisole, povidone, crospovidone, croscarmellose sodium, mannitol, sucrose, acacia, lactose monohydrate, confectionary sugar, microcrystalline cellulose, sodium laurel sulfate, magnesium stearate, talc, and silicon dioxide. The two active thyroid hormones: 3,3′,5,5′-tetra-iodo-l-thyronine (l-thyroxine-T4) and 3,3′,5-tri-iodo-l-thyronine (T3) and degradation products including di-iodothyronine (T2), thyronine (T0), tyrosine (Tyr), di-iodotyrosine (DIT), mono-iodotyrosine (MIT), 3,3′,5,5′-tetra-iodothyroacetic acid (T4AA) and 3,3′,5-tri-iodothyroacetic acid (T3AA) were assayed by the current method. The separation of l-thyroxine and eight metabolites along with theophylline (internal standard) was achieved using a C18 column (25°C) with a mobile phase of trifluoroacetic acid (0.1%, v/v, pH 3)–acetonitrile in gradient elution at 0.8ml/min at 223nm. The sample diluent was 0.01M methanolic NaOH. Method was validated according to FDA, USP, and ICH guidelines for inter-day accuracy, precision, and robustness after checking performance with system suitability. Tyr (4.97min), theophylline (9.09min), MIT (9.55min), DIT (11.37min), T0 (11.63min), T2 (14.47min), T3 (16.29min), T4 (17.60min), T3AA (22.71min), and T4AA (24.83min) separated in a single chromatographic run. Linear relationship (r 2 >0.99) was observed between the peak area ratio and the concentrations for all of the compounds within the range of 2–20μg/ml. The total time for analysis, equilibration and recovery was 40min. The method was shown to separate well from commonly employed formulation excipients. Accuracy ranged from 95 to 105% for T4 and 90 to 110% for all other compounds. Precision was <2% for all the compounds. The method was found to be robust with minor changes in injection volume, flow rate, column temperature, and gradient ratio. Validation results indicated that the method shows satisfactory linearity, precision, accuracy, and ruggedness and also stress degradation studies indicated that the method can be used as stability indicating method for l-thyroxine in the presence of excipients. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EXCIPIENTS
KW - STABILIZING agents
KW - THYROID hormones
KW - METHYLXANTHINES
KW - Degradation products
KW - Excipients
KW - Impurities
KW - Levothyroxine
KW - Validation
N1 - Accession Number: 33344049; Shah, R.B. 1 Bryant, A. 1 Collier, J. 1,2 Habib, M.J. 2 Khan, M.A. 1; Email Address: Mansoor.khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, United States 2: Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, United States; Source Info: Aug2008, Vol. 360 Issue 1/2, p77; Subject Term: EXCIPIENTS; Subject Term: STABILIZING agents; Subject Term: THYROID hormones; Subject Term: METHYLXANTHINES; Author-Supplied Keyword: Degradation products; Author-Supplied Keyword: Excipients; Author-Supplied Keyword: Impurities; Author-Supplied Keyword: Levothyroxine; Author-Supplied Keyword: Validation; NAICS/Industry Codes: 325613 Surface Active Agent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijpharm.2008.04.018
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Eichelberger, Maryna
AU - Golding, Hana
AU - Hess, Maureen
AU - Weir, Jerry
AU - Subbarao, Kanta
AU - Luke, Catherine J.
AU - Friede, Martin
AU - Wood, David
T1 - FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10–11, 2007
JO - Vaccine
JF - Vaccine
Y1 - 2008/08/12/
VL - 26
IS - 34
M3 - Proceeding
SP - 4299
EP - 4303
SN - 0264410X
AB - Abstract: The goals of the workshop were to identify gaps in our knowledge and abilities to address the unique challenges encountered in the development of vaccines intended to protect against pandemic influenza and to facilitate implementation of a global research agenda to improve efficacy assessment of pandemic influenza vaccines. This workshop included discussions on: (i) current knowledge regarding immune correlates of protection against seasonal influenza; (ii) human immune responses to avian influenza infection and vaccines for novel influenza viruses; (iii) limitations of currently available assays to evaluate vaccine immunogenicity; and (iv) potential insights from animal models for correlates of protection against avian influenza. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Influenza
KW - Immune response
KW - Respiratory infections
KW - Influenza -- Prevention
KW - Avian influenza
KW - Correlated of protection
KW - Influenza type A
KW - Pandemic
N1 - Accession Number: 33389196; Eichelberger, Maryna 1; Golding, Hana; Email Address: hana.golding@fda.hhs.gov; Hess, Maureen 1; Weir, Jerry 1; Subbarao, Kanta 2; Luke, Catherine J. 2; Friede, Martin 3; Wood, David 3; Affiliations: 1: US Food and Drug Administration, Center for Biologics Evaluation and Research Office of Vaccines Research and Review/Division of Viral Products, Bethesda, MD 20892, USA; 2: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 33, Room 3E13C.4, 33 North Drive, MSC 3203, Bethesda, MD 20892, USA; 3: World Health Organization, 20 Avenue Appia, Geneva Ch-1211, Switzerland; Issue Info: Aug2008, Vol. 26 Issue 34, p4299; Thesaurus Term: Influenza; Thesaurus Term: Immune response; Subject Term: Respiratory infections; Subject Term: Influenza -- Prevention; Author-Supplied Keyword: Avian influenza; Author-Supplied Keyword: Correlated of protection; Author-Supplied Keyword: Influenza type A; Author-Supplied Keyword: Pandemic; Number of Pages: 5p; Document Type: Proceeding
L3 - 10.1016/j.vaccine.2008.06.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33389196&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ye, Hongping
AU - Hill, John
AU - Kauffman, John
AU - Gryniewicz, Connie
AU - Han, Xianlin
T1 - Detection of protein modifications and counterfeit protein pharmaceuticals using isotope tags for relative and absolute quantification and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry: Studies of insulins
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2008/08/15/
VL - 379
IS - 2
M3 - Article
SP - 182
EP - 191
SN - 00032697
AB - Abstract: Isotope tags for relative and absolute quantification (iTRAQ) reagent coupled with matrix-assisted laser desorption/ionization tandem time-of-flight (MALDI-TOF/TOF) mass spectrometric analysis has been evaluated as both a qualitative and quantitative method for the detection of modifications to active pharmaceutical ingredients derived from recombinant DNA technologies and as a method to detect counterfeit drug products. Five types of insulin (human, bovine, porcine, Lispro, and Lantus) were used as model products in the study because of their minor variations in amino acid sequence. Several experiments were conducted in which each insulin variant was separately digested with Glu-C, and the digestate was labeled with one of four different iTRAQ reagents. All digestates were then combined for desalting and MALDI-TOF/TOF mass spectrometric analysis. When the digestion procedure was optimized, the insulin sequence coverage was 100%. Five different types of insulin were readily differentiated, including human insulin (P28K29) and Lispro insulin (K28P29), which differ only by the interchange of two contiguous residues. Moreover, quantitative analyses show that the results obtained from the iTRAQ method agree well with those determined by other conventional methods. Collectively, the iTRAQ method can be used as a qualitative and quantitative technique for the detection of protein modification and counterfeiting. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOTOPES
KW - INSULIN
KW - MASS spectrometry
KW - DNA
KW - Aggregation
KW - Counterfeit
KW - Deamidation
KW - Generic protein drugs
KW - Glu-C
KW - Insulins
KW - iTRAQ/MALDI
N1 - Accession Number: 32846817; Ye, Hongping 1; Email Address: hongping.ye@fda.hhs.gov Hill, John 2 Kauffman, John 1 Gryniewicz, Connie 1 Han, Xianlin 3; Affiliation: 1: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, MO 63101, USA 2: U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drug Quality Assessment, Silver Spring, MD 20993, USA 3: Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Source Info: Aug2008, Vol. 379 Issue 2, p182; Subject Term: ISOTOPES; Subject Term: INSULIN; Subject Term: MASS spectrometry; Subject Term: DNA; Author-Supplied Keyword: Aggregation; Author-Supplied Keyword: Counterfeit; Author-Supplied Keyword: Deamidation; Author-Supplied Keyword: Generic protein drugs; Author-Supplied Keyword: Glu-C; Author-Supplied Keyword: Insulins; Author-Supplied Keyword: iTRAQ/MALDI; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ab.2008.04.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=32846817&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kaldhone, Pravin
AU - Nayak, Rajesh
AU - Lynne, Aaron M.
AU - David, Donna E.
AU - McDermott, Patrick F.
AU - Logue, Catherine M.
AU - Foley, Steven L.
T1 - Characterization of Salmonella enterica serovar Heidelberg from Turkey-Associated Sources.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/08/15/
VL - 74
IS - 16
M3 - Article
SP - 5038
EP - 5046
SN - 00992240
AB - Salmonella enterica serovar Heidelberg strains are frequently associated with food-borne illness, with recent isolates showing higher rates of resistance to multiple antimicrobial agents. One hundred eighty S. enterica serovar Heidelberg isolates, collected from turkey-associated production and processing sources, were tested for antimicrobial susceptibility and compared by pulsed-field gel electrophoresis (PFGE) and plasmid profile analysis. The potential for the transfer of resistance between strains was studied by conjugation experiments. PFGE analysis using XbaI digestion identified eight clusters (based on 90% similarity), with the largest containing 71% of the isolates. Forty-two percent of the isolates were resistant to at least 1 of the 15 antimicrobial agents tested, and 4% of the isolates were resistant to 8 or more antimicrobial agents. Resistances to streptomycin (32%), tetracycline (30%), and kanamycin (24%) were most commonly detected. Interestingly, the XbaI PFGE profiles of selective multidrug-resistant strains (n = 22) of S. enterica serovar Heidelberg from turkey-associated sources were indistinguishable from the predominant profile (JF6X01.0022) detected in isolates associated with human infections. These isolates were further differentiated into seven distinct profiles following digestion with the BlnI enzyme, with the largest cluster comprising 15 isolates from veterinary diagnostic and turkey processing environments. Conjugation experiments indicated that resistance to multiple antimicrobial agents was transferable among strains with diverse PFGE profiles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - FOODBORNE diseases
KW - GEL electrophoresis
KW - ANTI-infective agents
KW - STREPTOMYCIN
KW - TURKEYS
N1 - Accession Number: 34148573; Kaldhone, Pravin 1,2 Nayak, Rajesh 3 Lynne, Aaron M. 1 David, Donna E. 1 McDermott, Patrick F. 4 Logue, Catherine M. 5 Foley, Steven L. 1,2; Email Address: foley.steven@mcrf.mfldclin.edu; Affiliation: 1: National Farm Medicine Center, Marshfield Clinic Research Foundation Marshfield, Wisconsin 2: Department of Biology, University of Central Arkansas, Conway, Arkansas 3: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 4: Division of Animal and Food Microbiology, Center for Veterinary Medicine, US. Food and Drug Administration, Laurel, Maryland 5: Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota; Source Info: Aug2008, Vol. 74 Issue 16, p5038; Subject Term: SALMONELLA; Subject Term: FOODBORNE diseases; Subject Term: GEL electrophoresis; Subject Term: ANTI-infective agents; Subject Term: STREPTOMYCIN; Subject Term: TURKEYS; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 112330 Turkey Production; NAICS/Industry Codes: 311615 Poultry Processing; Number of Pages: 9p; Illustrations: 3 Diagrams, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.00409-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34148573&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Jinchun
AU - Schnackenberg, Laura K.
AU - Holland, Ricky D.
AU - Schmitt, Thomas C.
AU - Cantor, Glenn H.
AU - Dragan, Yvonne P.
AU - Beger, Richard D.
T1 - Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2008/08/15/
VL - 871
IS - 2
M3 - Article
SP - 328
EP - 340
SN - 15700232
AB - Abstract: Urinary metabolic perturbations associated with acute and chronic acetaminophen-induced hepatotoxicity were investigated using nuclear magnetic resonance (NMR) spectroscopy and ultra performance liquid chromatography/mass spectrometry (UPLC/MS) metabonomics approaches to determine biomarkers of hepatotoxicity. Acute and chronic doses of acetaminophen (APAP) were administered to male Sprague-Dawley rats. NMR and UPLC/MS were able to detect both drug metabolites and endogenous metabolites simultaneously. The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar. Histopathology and clinical chemistry studies were performed and correlated well with the PCA analysis and magnitude of metabolite changes. Depletion of antioxidants (e.g. ferulic acid), trigonelline, S-adenosyl-l-methionine, and energy-related metabolites indicated that oxidative stress was caused by acute and chronic acetaminophen administration. Similar patterns of metabolic changes in response to acute or chronic dosing suggest similar detoxification and recovery mechanisms following APAP administration. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETAMINOPHEN
KW - NUCLEAR magnetic resonance
KW - SPECTRUM analysis
KW - METHIONINE
KW - OXIDATIVE stress
KW - Acetaminophen
KW - Metabolomics
KW - Metabonomics
N1 - Accession Number: 33631436; Sun, Jinchun 1 Schnackenberg, Laura K. 1 Holland, Ricky D. 1 Schmitt, Thomas C. 1 Cantor, Glenn H. 2 Dragan, Yvonne P. 1 Beger, Richard D. 1; Email Address: Richard.Beger@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States 2: Investigative Toxicology, Pharmacia Corp., Kalamazoo, MI 49001, United States; Source Info: Aug2008, Vol. 871 Issue 2, p328; Subject Term: ACETAMINOPHEN; Subject Term: NUCLEAR magnetic resonance; Subject Term: SPECTRUM analysis; Subject Term: METHIONINE; Subject Term: OXIDATIVE stress; Author-Supplied Keyword: Acetaminophen; Author-Supplied Keyword: Metabolomics; Author-Supplied Keyword: Metabonomics; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.jchromb.2008.04.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33631436&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubin, Steven A.
AU - Li Qi
AU - Audet, Susette A.
AU - Sullivan, Bradley
AU - Carbone, Kathryn M.
AU - Bellini, William J.
AU - Rota, Paul A.
AU - Sirota, Lev
AU - Beeler, Judy
T1 - Antibody Induced by Immunization with the Jeryl Lynn Mumps Vaccine Strain Effectively Neutralizes a Heterologous Wild-Type Mumps Virus Associated with a Large Outbreak.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/08/15/
VL - 198
IS - 4
M3 - Article
SP - 508
EP - 515
SN - 00221899
AB - Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A vaccine strains used in the countries affected by the outbreaks. This finding suggests that genotype A vaccine strains could have reduced efficacy against heterologous mumps viruses. The remote history of vaccination also suggests that waning immunity could have contributed to susceptibility. To examine these issues, we obtained consecutive serum samples from children at different intervals after vaccination and assayed the ability of these samples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type virus obtained during the mumps outbreak that occurred in the United States in 2006. Although the geometric mean neutralizing antibody titers against the genotype G virus were approximately one-half the titers measured against the vaccine strain, and although titers to both viruses decreased with time after vaccination, antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralized the outbreak-associated virus at all time points tested. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - MUMPS -- Vaccination
KW - COMMUNICABLE diseases -- Prevention
KW - IMMUNIZATION
KW - PHYLOGENY
KW - EPIDEMICS
KW - VACCINATION
KW - HEALTH risk assessment
KW - UNITED States
N1 - Accession Number: 33359029; Rubin, Steven A. 1; Email Address: steven.rubin@fda.hhs.gov Li Qi 1 Audet, Susette A. 1 Sullivan, Bradley 2 Carbone, Kathryn M. 1 Bellini, William J. 3 Rota, Paul A. 3 Sirota, Lev 1 Beeler, Judy 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 2: Department of Pediatrics, Marshfield Clinic, Marshfield, Wisconsin 3: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: 8/15/2008, Vol. 198 Issue 4, p508; Subject Term: IMMUNOGLOBULINS; Subject Term: MUMPS -- Vaccination; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: IMMUNIZATION; Subject Term: PHYLOGENY; Subject Term: EPIDEMICS; Subject Term: VACCINATION; Subject Term: HEALTH risk assessment; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1086/590115
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33359029&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105666664
T1 - Antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralizes a heterologous wild-type mumps virus associated with a large outbreak.
AU - Rubin SA
AU - Audet SA
AU - Sullivan B
AU - Carbone KM
AU - Bellini WJ
AU - Rota PA
AU - Sirota L
AU - Beeler J
Y1 - 2008/08/15/
N1 - Accession Number: 105666664. Language: English. Entry Date: 20081017. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Supported in part by: National Vaccine Program Office administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Dept of Energy and the US Food and Drug Administration (FDA). NLM UID: 0413675.
KW - Immunity -- Evaluation
KW - Mumps Vaccine -- Immunology
KW - Mumps -- Prevention and Control
KW - Adolescence
KW - Antibodies, Viral -- Blood
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Immunoassay
KW - Mann-Whitney U Test
KW - Paramyxoviruses -- Classification
KW - Repeated Measures
KW - T-Tests
KW - Time Factors
KW - Wisconsin
KW - Human
SP - 508
EP - 515
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 198
IS - 4
PB - Oxford University Press / USA
AB - Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A vaccine strains used in the countries affected by the outbreaks. This finding suggests that genotype A vaccine strains could have reduced efficacy against heterologous mumps viruses. The remote history of vaccination also suggests that waning immunity could have contributed to susceptibility. To examine these issues, we obtained consecutive serum samples from children at different intervals after vaccination and assayed the ability of these samples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type virus obtained during the mumps outbreak that occurred in the United States in 2006. Although the geometric mean neutralizing antibody titers against the genotype G virus were approximately one-half the titers measured against the vaccine strain, and although titers to both viruses decreased with time after vaccination, antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralized the outbreak-associated virus at all time points tested. Copyright © 2008 Infectious Diseases Society of America
SN - 0022-1899
AD - Division of Viral Products, Center for Biologics Evaluation and Research, United State Food and Drug Administration, Bldg. 29A, Rm. 1A-21, 8800 Rockville Pike, Bethesda, MD 20892; steven.rubin@fda.hhs.gov
U2 - PMID: 18558869.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105666664&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Peters, Nathan C.
AU - Egen, Jackson G.
AU - Secundino, Nagila
AU - Debrabant, Alain
AU - Kimblin, Nicola
AU - Kamhawi, Shaden
AU - Lawyer, Phillip
AU - Fay, Michael P.
AU - Germain, Ronald N.
AU - Sacks, David
T1 - In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies.
JO - Science
JF - Science
Y1 - 2008/08/15/
VL - 321
IS - 5891
M3 - Article
SP - 970
EP - 974
SN - 00368075
AB - Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vector sand flies have been difficult to examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid and sustained neutrophilic infiltrate at localized sand fly bite sites. Invading neutrophils efficiently captured Leishmania major (L.m.) parasites early after sand fly transmission or needle inoculation, but phagocytosed L.m. remained viable and infected neutrophils efficiently initiated infection. Furthermore, neutrophil depletion reduced, rather than enhanced, the ability of parasites to establish productive infections. Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEISHMANIASIS
KW - NEUTROPHILS
KW - SAND flies
KW - IMAGING systems in medicine
KW - FLOW cytometry
KW - PARASITES
KW - INFECTION
KW - ANIMALS as carriers of disease
KW - MEDICAL microbiology
KW - TRANSMISSION
N1 - Accession Number: 34144676; Peters, Nathan C. 1 Egen, Jackson G. 2; Email Address: jegen@niaid.nih.gov Secundino, Nagila 1 Debrabant, Alain 3 Kimblin, Nicola 1 Kamhawi, Shaden 1 Lawyer, Phillip 1 Fay, Michael P. 4 Germain, Ronald N. 2 Sacks, David 1; Email Address: dsacks@nih.gov; Affiliation: 1: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA 2: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA 3: Laboratory of Bacterial, Parasitic, and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA 4: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA; Source Info: 8/15/2008, Vol. 321 Issue 5891, p970; Subject Term: LEISHMANIASIS; Subject Term: NEUTROPHILS; Subject Term: SAND flies; Subject Term: IMAGING systems in medicine; Subject Term: FLOW cytometry; Subject Term: PARASITES; Subject Term: INFECTION; Subject Term: ANIMALS as carriers of disease; Subject Term: MEDICAL microbiology; Subject Term: TRANSMISSION; Number of Pages: 5p; Illustrations: 4 Diagrams; Document Type: Article
L3 - 10.1126/science.1159194
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34144676&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yourick, Jeffrey J.
AU - Jung, Connie T.
AU - Bronaugh, Robert L.
T1 - In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: Significance of the skin reservoir and prediction of systemic absorption
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/08/15/
VL - 231
IS - 1
M3 - Article
SP - 117
EP - 121
SN - 0041008X
AB - Abstract: The percutaneous absorption of retinol (Vitamin A) from cosmetic formulations was studied to predict systemic absorption and to understand the significance of the skin reservoir in in vitro absorption studies. Viable skin from fuzzy rat or human subjects was assembled in flow-through diffusion cells for in vitro absorption studies. In vivo absorption studies using fuzzy rats were performed in glass metabolism cages for collection of urine, feces, and body content. Retinol (0.3%) formulations (hydroalcoholic gel and oil-in-water emulsion) containing 3H-retinol were applied and absorption was measured at 24 or 72 h. All percentages reported are % of applied dose. In vitro studies using human skin and the gel and emulsion vehicles found 0.3 and 1.3% retinol, respectively, in receptor fluid at 24 h. Levels of absorption in the receptor fluid increased over 72 h with the gel and emulsion vehicles. Using the gel vehicle, in vitro rat skin studies found 23% in skin and 6% in receptor fluid at 24 h, while 72-h studies found 18% in skin and 13% in receptor fluid. Thus, significant amounts of retinol remained in rat skin at 24 h and decreased over 72 h, with proportional increases in receptor fluid. In vivo rat studies with the gel found 4% systemic absorption of retinol after 24 h and systemic absorption did not increase at 72 h. Retinol remaining in rat skin after in vivo application was 18% and 13% of the applied dermal dose after 24 and 72 h, respectively. Similar observations were made with the oil-in water emulsion vehicle in the rat. Retinol formed a reservoir in rat skin both in vivo and in vitro. Little additional retinol was bioavailable after 24 h. Comparison of these in vitro and in vivo results for absorption through rat skin indicates that the 24-h in vitro receptor fluid value accurately estimated 24-h in vivo systemic absorption. Therefore, the best single estimate of retinol systemic absorption from in vitro human skin studies is the 24-h receptor fluid value. However, the receptor fluid value from the 72-h extended study may be used in a worst-case exposure estimate. In conclusion, in vivo skin absorption studies can be useful in determining whether to include material in the in vitro skin reservoir as absorbable material in estimates of systemic absorption. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETINOIDS
KW - VITAMIN A
KW - GELATION
KW - BIOCHEMISTRY
KW - Absorption
KW - Dermal
KW - Lipophilic
KW - Retinol
KW - Skin
N1 - Accession Number: 33640745; Yourick, Jeffrey J. 1; Email Address: jeffrey.yourick@fda.hhs.gov Jung, Connie T. 2 Bronaugh, Robert L. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA 2: U.S. Food and Drug Administration, Office of the Commissioner, Office of Policy, Rockville, MD 20857, USA; Source Info: Aug2008, Vol. 231 Issue 1, p117; Subject Term: RETINOIDS; Subject Term: VITAMIN A; Subject Term: GELATION; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Absorption; Author-Supplied Keyword: Dermal; Author-Supplied Keyword: Lipophilic; Author-Supplied Keyword: Retinol; Author-Supplied Keyword: Skin; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.taap.2008.04.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33640745&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yourick, Jeffrey J.
AU - Jung, Connie T.
AU - Bronaugh, Robert L.
T1 - In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: Significance of the skin reservoir and prediction of systemic absorption
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/08/15/
VL - 231
IS - 1
M3 - Article
SP - 117
EP - 121
SN - 0041008X
AB - Abstract: The percutaneous absorption of retinol (Vitamin A) from cosmetic formulations was studied to predict systemic absorption and to understand the significance of the skin reservoir in in vitro absorption studies. Viable skin from fuzzy rat or human subjects was assembled in flow-through diffusion cells for in vitro absorption studies. In vivo absorption studies using fuzzy rats were performed in glass metabolism cages for collection of urine, feces, and body content. Retinol (0.3%) formulations (hydroalcoholic gel and oil-in-water emulsion) containing 3H-retinol were applied and absorption was measured at 24 or 72 h. All percentages reported are % of applied dose. In vitro studies using human skin and the gel and emulsion vehicles found 0.3 and 1.3% retinol, respectively, in receptor fluid at 24 h. Levels of absorption in the receptor fluid increased over 72 h with the gel and emulsion vehicles. Using the gel vehicle, in vitro rat skin studies found 23% in skin and 6% in receptor fluid at 24 h, while 72-h studies found 18% in skin and 13% in receptor fluid. Thus, significant amounts of retinol remained in rat skin at 24 h and decreased over 72 h, with proportional increases in receptor fluid. In vivo rat studies with the gel found 4% systemic absorption of retinol after 24 h and systemic absorption did not increase at 72 h. Retinol remaining in rat skin after in vivo application was 18% and 13% of the applied dermal dose after 24 and 72 h, respectively. Similar observations were made with the oil-in water emulsion vehicle in the rat. Retinol formed a reservoir in rat skin both in vivo and in vitro. Little additional retinol was bioavailable after 24 h. Comparison of these in vitro and in vivo results for absorption through rat skin indicates that the 24-h in vitro receptor fluid value accurately estimated 24-h in vivo systemic absorption. Therefore, the best single estimate of retinol systemic absorption from in vitro human skin studies is the 24-h receptor fluid value. However, the receptor fluid value from the 72-h extended study may be used in a worst-case exposure estimate. In conclusion, in vivo skin absorption studies can be useful in determining whether to include material in the in vitro skin reservoir as absorbable material in estimates of systemic absorption. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Retinoids
KW - Vitamin A
KW - Gelation
KW - Biochemistry
KW - Absorption
KW - Dermal
KW - Lipophilic
KW - Retinol
KW - Skin
N1 - Accession Number: 33640745; Yourick, Jeffrey J. 1; Email Address: jeffrey.yourick@fda.hhs.gov; Jung, Connie T. 2; Bronaugh, Robert L. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA; 2: U.S. Food and Drug Administration, Office of the Commissioner, Office of Policy, Rockville, MD 20857, USA; Issue Info: Aug2008, Vol. 231 Issue 1, p117; Subject Term: Retinoids; Subject Term: Vitamin A; Subject Term: Gelation; Subject Term: Biochemistry; Author-Supplied Keyword: Absorption; Author-Supplied Keyword: Dermal; Author-Supplied Keyword: Lipophilic; Author-Supplied Keyword: Retinol; Author-Supplied Keyword: Skin; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.taap.2008.04.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33640745&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - de Breyne, Sylvain
AU - Bonderoff, Jennifer M.
AU - Chumakov, Konstantin M.
AU - Lloyd, Richard E.
AU - Hellen, Christopher U.T.
T1 - Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases
JO - Virology
JF - Virology
Y1 - 2008/08/15/
VL - 378
IS - 1
M3 - Article
SP - 118
EP - 122
SN - 00426822
AB - Abstract: The enteroviruses poliovirus (PV), Coxsackie B virus (CVB) and rhinovirus (HRV) are members of Picornaviridae that inhibit host cell translation early in infection. Enterovirus translation soon predominates in infected cells, but eventually also shuts off. This complex pattern of modulation of translation suggests regulation by a multifactorial mechanism. We report here that eIF5B is proteolytically cleaved during PV and CVB infection of cultured cells, beginning at 3 hours post-infection and increasing thereafter. Recombinant PV, CVB and HRV 3Cpro cleaved purified native rabbit eukaryotic initiation factor (eIF) 5B in vitro at a single site (VVEQ↓G, equivalent to VMEQ↓G479 in human eIF5B) that is consistent with the cleavage specificity of enterovirus 3C proteases. Cleavage separates the N-terminal domain of eIF5B from its essential conserved central GTPase and C-terminal domains. 3Cpro-mediated cleavage of eIF5B may thus play an accessory role in the shutoff of translation that occurs in enterovirus-infected cells. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROVIRUSES
KW - POLIOVIRUS
KW - PROTEOLYTIC enzymes
KW - RHINOVIRUSES
KW - PICORNAVIRUSES
KW - CELL culture
KW - VIRUS diseases
KW - Coxsackievirus
KW - eIF5B
KW - Poliovirus
KW - Protease
KW - Rhinovirus
KW - Translation shutoff
KW - Translation shutoff">Coxsackievirus
N1 - Accession Number: 33466991; de Breyne, Sylvain 1 Bonderoff, Jennifer M. 2 Chumakov, Konstantin M. 3 Lloyd, Richard E. 2 Hellen, Christopher U.T. 1; Email Address: christopher.hellen@downstate.edu; Affiliation: 1: Department of Microbiology and Immunology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA 2: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA 3: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Rockville, MD 20852, USA; Source Info: Aug2008, Vol. 378 Issue 1, p118; Subject Term: ENTEROVIRUSES; Subject Term: POLIOVIRUS; Subject Term: PROTEOLYTIC enzymes; Subject Term: RHINOVIRUSES; Subject Term: PICORNAVIRUSES; Subject Term: CELL culture; Subject Term: VIRUS diseases; Author-Supplied Keyword: Coxsackievirus; Author-Supplied Keyword: eIF5B; Author-Supplied Keyword: Poliovirus; Author-Supplied Keyword: Protease; Author-Supplied Keyword: Rhinovirus; Author-Supplied Keyword: Translation shutoff; Author-Supplied Keyword: Translation shutoff">Coxsackievirus; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.virol.2008.05.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33466991&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Usonis, Vytautas
AU - Bakasenas, Vytautas
AU - Lockhart, Stephen
AU - Baker, Sherryl
AU - Gruber, William
AU - Laudat, France
T1 - A clinical trial examining the effect of increased total CRM197 carrier protein dose on the antibody response to Haemophilus influenzae type b CRM197 conjugate vaccine
JO - Vaccine
JF - Vaccine
Y1 - 2008/08/18/
VL - 26
IS - 35
M3 - Article
SP - 4602
EP - 4607
SN - 0264410X
AB - Abstract: CRM197 is a carrier protein in certain conjugate vaccines. When multiple conjugate vaccines with the same carrier protein are administered simultaneously, reduced response to vaccines and/or antigens related to the carrier protein may occur. This study examined responses of infants who, in addition to diphtheria toxoid/tetanus toxoid/acellular pertussis vaccine (DTaP) received either diphtheria CRM197-based Haemophilus influenzae type b conjugate vaccine (HbOC) or HbOC and a diphtheria CRM197-based combination 9-valent pneumococcal conjugate vaccine/meningococcal group C conjugate vaccine. Administration of conjugate vaccines with CRM197 carrier protein load >50μg did not reduce response to CRM197 conjugate vaccines or immunogenicity to immunologically cross-reactive diphtheria toxoid. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Carrier proteins
KW - Vaccines
KW - Clinical trials
KW - Immunoglobulins
KW - Diphtheria
KW - Haemophilus influenzae
KW - Immunogenetics
KW - Conjugate vaccine
KW - CRM197
KW - Haemophilus influenzae type b
N1 - Accession Number: 33529956; Usonis, Vytautas 1; Email Address: vytautas.usonis@mf.vu.lt; Bakasenas, Vytautas 2; Lockhart, Stephen 3; Baker, Sherryl 4; Gruber, William 4; Laudat, France 5; Affiliations: 1: Vilnius University, Vilnius, Lithuania; 2: State Public Health Service Under the Ministry of Health, Vilnius, Lithuania; 3: Wyeth Vaccine Research, Taplow, United Kingdom; 4: Wyeth Vaccine Research, Pearl River, New York, USA; 5: Wyeth Vaccine Research, Paris, France; Issue Info: Aug2008, Vol. 26 Issue 35, p4602; Thesaurus Term: VACCINATION; Subject Term: Carrier proteins; Subject Term: Vaccines; Subject Term: Clinical trials; Subject Term: Immunoglobulins; Subject Term: Diphtheria; Subject Term: Haemophilus influenzae; Subject Term: Immunogenetics; Author-Supplied Keyword: Conjugate vaccine; Author-Supplied Keyword: CRM197; Author-Supplied Keyword: Haemophilus influenzae type b; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.05.087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33529956&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kubachka, Kevin M.
AU - Richardson, Douglas D.
AU - Heitkemper, Douglas T.
AU - Caruso, Joseph A.
T1 - Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/08/22/
VL - 1202
IS - 2
M3 - Article
SP - 124
EP - 131
SN - 00219673
AB - Abstract: The following work presents the exploration of three chromatographic separations in combination with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of chemical warfare agent degradation products (CWADPs). The robust ionization of ICP is virtually matrix independent thus enabling the examination of sample matrices generally considered too complicated for analysis by electrospray ionization (ESI) or atmospheric pressure chemical ionization MS with little to no sample preparation. The analysis was focused on detecting CWADPs in food matrices, as they present possible vehicles for terrorist contamination. Due to the specific detection of 31P by ICP-MS, resolution of analytes of interest from other P-containing interferences (H3PO4) was a crucial part of each separation. Up to 10 CWADPs were separated in the presence of H3PO4 with detection limits in the low part per billion levels using the methods described. Additionally, one method was tailored to be compatible with both ICP-MS and ESI-MS making structural verification possible. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTROSPRAY ionization mass spectrometry
KW - CHEMICAL warfare
KW - FOOD -- Composition
KW - SCIENTIFIC method
KW - Chemical warfare agent degradation products
KW - Food matrices
KW - LC–ESI-MS
KW - LC–ICP-MS
KW - Phosphate
N1 - Accession Number: 33528731; Kubachka, Kevin M. 1,2 Richardson, Douglas D. 1 Heitkemper, Douglas T. 3 Caruso, Joseph A. 1; Email Address: joseph.caruso@uc.edu; Affiliation: 1: Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA 2: Oak Ridge Associated Universities Research Fellow, US Food and Drug Administration, Cincinnati, OH 45237, USA 3: Forensic Chemistry Center, US Food and Drug Administration, Cincinnati, OH 45237, USA; Source Info: Aug2008, Vol. 1202 Issue 2, p124; Subject Term: ELECTROSPRAY ionization mass spectrometry; Subject Term: CHEMICAL warfare; Subject Term: FOOD -- Composition; Subject Term: SCIENTIFIC method; Author-Supplied Keyword: Chemical warfare agent degradation products; Author-Supplied Keyword: Food matrices; Author-Supplied Keyword: LC–ESI-MS; Author-Supplied Keyword: LC–ICP-MS; Author-Supplied Keyword: Phosphate; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.chroma.2008.04.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mason, B. W.
AU - Cartwright, J.
AU - Sandham, S.
AU - Whiteside, C.
AU - Salmon, R. L.
T1 - A patient notification exercise following infection control failures in a dental surgery.
JO - British Dental Journal
JF - British Dental Journal
Y1 - 2008/08/23/
VL - 205
IS - 4
M3 - Article
SP - E8
EP - E8
SN - 00070610
AB - Objectives To investigate the association between treatment by a dental healthcare worker (HCW) and patient infection with a blood-borne virus (BBV).Design Nested case control study.Setting A patient notification exercise (PNE) arising from a hepatitis C virus positive HCW that was undertaken because of deficiencies in infection control practice.Methods Cases were individuals with a BBV infection identified as a result of the PNE. Controls were randomly selected individuals with negative tests for BBVs. Detailed information on dental treatment was obtained from patient notes. Information on risk factors for BBV infection was obtained using a structured questionnaire administered by telephone interview.Results Thirty patients had evidence of infection with a BBV. The mean number of visits for treatment was 20.5 in cases and 18.6 in controls; the difference 1.8 (95% CI -5.4 to 9.1) was not statistically significant (p = 0.62). Transmission of hepatitis C in the dental setting was excluded by sequencing of the viral genome or establishing alternative risk factors.Conclusion There was no evidence of transmission of hepatitis C virus from the HCW to patients, or transmission of a BBV from patient to patient. To ensure consistent practice within the UK the National Institute for Health and Clinical Excellence should produce guidance on PNEs for the NHS. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Dental Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - DENTAL personnel & patient
KW - BLOODBORNE infections
KW - HEPATITIS C
KW - VIRAL genomes
KW - GREAT Britain
N1 - Accession Number: 33999295; Mason, B. W. 1; Email Address: brendan.mason@nphs.wales.nhs.uk Cartwright, J. 2 Sandham, S. 3 Whiteside, C. 4 Salmon, R. L. 1; Affiliation: 1: Consultant Epidemiologists, Communicable Disease Surveillance Centre Wales, National Public Health Service for Wales, The Temple of Peace and Health, Cathays Park, Cardiff, CF10 3NW, UK 2: Specialist Registrar in Public Health, Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold, CH7 1PZ, UK 3: Director of Dental Public Health, National Public Health Service for Wales, Royal Alexandra Hospital, Dental Department, Marine Drive, Rhyll, LL18 3AS, Australia 4: Consultant in Communicable Disease Control, Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold, CH7 1PZ, UK; Source Info: 8/23/2008, Vol. 205 Issue 4, pE8; Subject Term: DENTAL care; Subject Term: DENTAL personnel & patient; Subject Term: BLOODBORNE infections; Subject Term: HEPATITIS C; Subject Term: VIRAL genomes; Subject Term: GREAT Britain; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 621210 Offices of Dentists; Number of Pages: 1p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1038/sj.bdj.2008.656
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105626513
T1 - A patient notification exercise following infection control failures in a dental surgery.
AU - Mason BW
AU - Cartwright J
AU - Sandham S
AU - Whiteside C
AU - Salmon RL
Y1 - 2008/08/23/
N1 - Accession Number: 105626513. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Expert Peer Reviewed; UK & Ireland. Special Interest: Dental Care. NLM UID: 7513219.
KW - Bloodborne Pathogens
KW - Dentistry
KW - Dentists
KW - Disease Transmission, Professional-to-Patient
KW - Hepatitis C -- Transmission
KW - Case Control Studies
KW - Cross Infection -- Transmission
KW - Dental Care -- Classification
KW - Dental Care -- Statistics and Numerical Data
KW - Disease Surveillance
KW - Female
KW - Genome
KW - Great Britain
KW - Health Screening
KW - Hepatitis Viruses
KW - Hepatitis Viruses -- Classification
KW - Human Immunodeficiency Virus -- Classification
KW - Male
KW - Middle Age
KW - Patient History Taking
KW - Risk Assessment
KW - Time Factors
KW - Viremia
KW - Human
SP - E8
EP - 195
JO - British Dental Journal
JF - British Dental Journal
JA - BR DENT J
VL - 205
IS - 4
CY - London,
PB - Nature Publishing Group
SN - 0007-0610
AD - Communicable Disease Surveillance Centre Wales, National Public Health Service for Wales, The Temple of Peace and Health, Cathays Park, Cardiff CF103NW. brendan.mason@nphs.wales.nhs.uk
U2 - PMID: 18650798.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105626513&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105705359
T1 - Parental perceptions of dental/oral health among children with and without special health care needs.
AU - Kenney MK
AU - Kogan MD
AU - Crall JJ
Y1 - 2008/09//Sep/Oct2008
N1 - Accession Number: 105705359. Language: English. Entry Date: 20081205. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Dental Care; Pediatric Care. NLM UID: 101089367.
KW - Dental Care -- Economics
KW - Oral Health -- In Infancy and Childhood
KW - Parental Attitudes
KW - Adolescence
KW - Chi Square Test
KW - Child
KW - Child, Medically Fragile
KW - Child, Preschool
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Infant
KW - Insurance, Dental
KW - Logistic Regression
KW - Male
KW - Multiple Regression
KW - Odds Ratio
KW - Self Report
KW - Human
SP - 312
EP - 320
JO - Ambulatory Pediatrics
JF - Ambulatory Pediatrics
JA - AMBULATORY PEDIATR
VL - 8
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - Objectives: The aims of this study were to determine the prevalence of parent-reported preventive dental care and better dental health in children with special health care needs (CSHCN) and to identify parent-reported dental problems, reasons for lack of preventive dental care, and factors associated with receiving preventive care and having better perceived dental health in CSHCN. A comparison group of children without special needs (CWOSN) was included.Methods: We analyzed the 2003 National Survey of Children's Health by using a sample of 17 001 CSHCN and a comparison group of CWOSN. Descriptive and between-group chi-square statistics were used to analyze child characteristics, parent-perceived dental problems, and reasons for lack of preventive dental care. Factors associated with receipt of preventive dental care and better reported dental health were examined using logistic regression.Results: Approximately 80% of CSHCN and 72% of CWOSN received preventive dental care. CSHCN parents reported more dental problems and fewer described their children as having good to excellent dental health compared to CWOSN, despite greater odds of having dental coverage and receiving preventive dental care. Disparities were evident in preventive dental care and dental health based on income, education, and insurance coverage.Conclusions: Most parents of CSHCN and CWOSN report that their children receive preventive dental care and have good to excellent dental health; however, disparities in dental health and receipt of preventive dental care exist. Accessing care coordination by using the medical/dental home model, particularly for CSHCN, may alleviate the situation in which some of the most vulnerable children are experiencing the worst dental health.
SN - 1530-1567
AD - Dept of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Rm 18-41, Rockville, Maryland 20857; mkenney@hrsa.gov
U2 - PMID: 18922505.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105705359&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ki Moon Bang
AU - Attfield, Michael D.
AU - Wood, John M.
AU - Syamlal, Girija
T1 - National Trends in Silicosis Mortality in the United States, 1981-2004.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/09//
VL - 51
IS - 9
M3 - Article
SP - 633
EP - 639
SN - 02713586
AB - The article presents an overview of the silicosis mortality trends in the U.S. from 1981-2004. It is considered an occupational lung disease attributed to the inhalation of dust containing fine particles of crystalline. This usually occurs in mining, quarrying, drilling and tunneling operations. It has a long latency period ranging from 10 to 30 years from the onset of exposure to the recognition of radiographic manifestation. Studies show that deaths caused by the ailment around 1981 occurred before the introduction of national compliance limits for silica dust exposure. The national compliance limits on silica began in the early 1970s. Presented are the details of the mortality caused by the disease.
KW - Occupational diseases
KW - Mineral industries
KW - Industrial safety
KW - Silicosis
KW - Lungs -- Dust diseases
KW - Silicotics
KW - Chronically ill
KW - Occupational mortality
KW - United States
KW - industry
KW - mortality
KW - occupation
KW - proportionate mortality ratios
KW - silicosis
N1 - Accession Number: 34095366; Ki Moon Bang 1; Email Address: kmb2@cdc.gov; Attfield, Michael D. 1; Wood, John M. 1; Syamlal, Girija 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Sep2008, Vol. 51 Issue 9, p633; Thesaurus Term: Occupational diseases; Thesaurus Term: Mineral industries; Thesaurus Term: Industrial safety; Subject Term: Silicosis; Subject Term: Lungs -- Dust diseases; Subject Term: Silicotics; Subject Term: Chronically ill; Subject Term: Occupational mortality; Subject: United States; Author-Supplied Keyword: industry; Author-Supplied Keyword: mortality; Author-Supplied Keyword: occupation; Author-Supplied Keyword: proportionate mortality ratios; Author-Supplied Keyword: silicosis; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph, 1 Map; Document Type: Article
L3 - 10.1002/ajim.20607
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34095366&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kubale, Travis
AU - Hiratzka, Shannon
AU - Henn, Scott
AU - Markey, Andrea
AU - Daniels, Robert
AU - Utterback, David
AU - Waters, Kathy
AU - Silver, Sharon
AU - Robinson, Cynthia
AU - Macievic, Gregory
AU - Lodwick, Jeffrey
T1 - A Cohort Mortality Study of Chemical Laboratory Workers at Department of Energy Nuclear Plants.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/09//
VL - 51
IS - 9
M3 - Article
SP - 656
EP - 667
SN - 02713586
AB - The article reports on the research conducted on the mortality rates of chemical laboratory workers of the Department of Energy Nuclear Plants in the U.S. These workers are regularly exposed to highly toxic chemical agents and at risk of developing cancer. Research shows that there is a low overall mortality attributed to the healthy workers. Mortality among workers from some site-specific cancer included leukemia, lympatic and hematopoietic cancers among males and urinary cancers. The study cohort results reveal that common types of cancer found in them include bladder, kidney, prostate, brain, bone and digestive system.
KW - Cancer research
KW - Chemical laboratories
KW - Kidneys -- Cancer
KW - Leukemia
KW - Mortality
KW - Hematopoietic system -- Cancer
KW - Bone marrow
KW - United States
KW - cancer
KW - Department of Energy
KW - laboratory workers
KW - mortality study
KW - multiple myeloma
KW - United States. Dept. of Energy
N1 - Accession Number: 34095369; Kubale, Travis 1; Email Address: tek2@cdc.gov; Hiratzka, Shannon 1; Henn, Scott 1; Markey, Andrea 1; Daniels, Robert 1; Utterback, David 1; Waters, Kathy 1; Silver, Sharon 1; Robinson, Cynthia 1; Macievic, Gregory 1; Lodwick, Jeffrey 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio; Issue Info: Sep2008, Vol. 51 Issue 9, p656; Subject Term: Cancer research; Subject Term: Chemical laboratories; Subject Term: Kidneys -- Cancer; Subject Term: Leukemia; Subject Term: Mortality; Subject Term: Hematopoietic system -- Cancer; Subject Term: Bone marrow; Subject: United States; Author-Supplied Keyword: cancer; Author-Supplied Keyword: Department of Energy; Author-Supplied Keyword: laboratory workers; Author-Supplied Keyword: mortality study; Author-Supplied Keyword: multiple myeloma ; Company/Entity: United States. Dept. of Energy; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 12p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1002/ajim.20601
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34095369&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tak, SangWoo
AU - Roscoe, Robert J.
AU - Alarcon, Walter
AU - Jun Ju
AU - Sestito, John P.
AU - Sussell, Aaron L.
AU - Calvert, Geoffrey M.
T1 - Characteristics of US Workers Whose Blood Lead Levels Trigger the Medical Removal Protection Provision, and Conformity With Biological Monitoring Requirements, 2003-2005.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/09//
VL - 51
IS - 9
M3 - Article
SP - 691
EP - 700
SN - 02713586
AB - The article offers information on the attributes of workers with high blood lead levels and their implication in the U.S. It reveals that despite reports of reduced blood lead levels among adult workers in many industries, they are still exposed to dangerous levels of lead. Workers with blood levels (BLL) ≥60 µgrams per deciliters (µg/dl) for construction workers or with three or more consecutive BLL at least six months with average 50 µg/dl or greater are required to be removed from work that involves lead exposure exceeding the Occupational Safety & Health Administration (OSHA) action level. Workers with such BBL trigger the medical removal provision by industry sector.
KW - Lead
KW - Poisons -- Analysis
KW - Industrial safety
KW - Work-related injuries
KW - Industrial management
KW - Occupational medicine
KW - United States
KW - adult blood lead epidemiology and surveillance
KW - biological monitoring
KW - blood lead level
KW - medical removal protection
KW - medical surveillance
KW - United States. Occupational Safety & Health Administration
N1 - Accession Number: 34095373; Tak, SangWoo 1; Email Address: stak@cdc.gov; Roscoe, Robert J. 1; Alarcon, Walter 1; Jun Ju 2; Sestito, John P. 1; Sussell, Aaron L. 1; Calvert, Geoffrey M. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Constella Group, LLC, Durham, North Carolina; Issue Info: Sep2008, Vol. 51 Issue 9, p691; Thesaurus Term: Lead; Thesaurus Term: Poisons -- Analysis; Thesaurus Term: Industrial safety; Subject Term: Work-related injuries; Subject Term: Industrial management; Subject Term: Occupational medicine; Subject: United States; Author-Supplied Keyword: adult blood lead epidemiology and surveillance; Author-Supplied Keyword: biological monitoring; Author-Supplied Keyword: blood lead level; Author-Supplied Keyword: medical removal protection; Author-Supplied Keyword: medical surveillance ; Company/Entity: United States. Occupational Safety & Health Administration; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 926150 Regulation, Licensing, and Inspection of Miscellaneous Commercial Sectors; Number of Pages: 10p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1002/ajim.20603
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buckley, Jessie Poulin
AU - Sestito, John P.
AU - Hunting, Katherine L.
T1 - Fatalities in the Landscape and Horticultural Services Industry, 1992-2001.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/09//
VL - 51
IS - 9
M3 - Article
SP - 701
EP - 713
SN - 02713586
AB - The article offers information on the fatalities that occurred in landscape and horticultural services industry in the U.S. from 1992-2001. Eventhough landscape and horticultural services workers have high injury and illness rates, little is known about such fatalities is known about it. Data from the Bureau of Labor Statistics show that approximately 918,000 workers are employed in the industry whose services include agriculture, forestry and fishing. There were 1,101 fatalities during the 10-year period and the average fatality rate was 13.5 deaths per 100,000 full-time employees. Researchers found that the leading causes of death were transportation incidents, contact with objects or equipment, falls and exposure to harmful substances.
KW - Industrial safety
KW - Horticulture
KW - Industrial hygiene
KW - Work-related injuries
KW - Horticultural service industry
KW - Industrial management
KW - Occupational mortality
KW - United States
KW - census of fatal occupational injuries
KW - fatal injury
KW - occupation
KW - work
KW - United States. Bureau of Labor Statistics
N1 - Accession Number: 34095374; Buckley, Jessie Poulin 1; Email Address: jpoulin@gmail.com; Sestito, John P. 2; Hunting, Katherine L. 1; Affiliations: 1: Department of Environmental and Occupational Health, School of Public Health and Health Services, The George Washington University, Washington, District of Columbia; 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Health Evaluations and Field Studies, Cincinnati, Ohio; Issue Info: Sep2008, Vol. 51 Issue 9, p701; Thesaurus Term: Industrial safety; Thesaurus Term: Horticulture; Thesaurus Term: Industrial hygiene; Subject Term: Work-related injuries; Subject Term: Horticultural service industry; Subject Term: Industrial management; Subject Term: Occupational mortality; Subject: United States; Author-Supplied Keyword: census of fatal occupational injuries; Author-Supplied Keyword: fatal injury; Author-Supplied Keyword: occupation; Author-Supplied Keyword: work ; Company/Entity: United States. Bureau of Labor Statistics; NAICS/Industry Codes: 561730 Landscaping Services; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 13p; Illustrations: 10 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/ajim.20604
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reimschuessel, Renate
AU - Gieseker, Charles M.
AU - Miller, Ron A.
AU - Ward, Jeffrey
AU - Boehmer, Jamie
AU - Rummel, Nathan
AU - Heller, David N.
AU - Nochetto, Christina
AU - Hemakanthi de Alwis, G. K.
AU - Bataller, Neal
AU - Andersen, Wendy C.
AU - Turnipseed, Sherri B.
AU - Karbiwnyk, Christine W.
AU - Satzger, R. Duane
AU - Crowe, John B.
AU - Wilber, Nancy R.
AU - Reinhard, Mary K.
AU - Roberts, John F.
AU - Witkowski, Mark R.
T1 - Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs.
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
Y1 - 2008/09//
VL - 69
IS - 9
M3 - Article
SP - 1217
EP - 1228
SN - 00029645
AB - Objective--To determine whether renal crystals can be experimentally induced in animals fed melamine or the related triazine compound cyanuric acid, separately or in combination, and to compare experimentally induced crystals with those from a cat with triazine-related renal failure. Animals--75 fish (21 tilapia, 24 rainbow trout, 15 channel catfish, and 15 Atlantic salmon), 4 pigs, and 1 cat that was euthanatized because of renal failure. Procedures--Fish and pigs were fed a target dosage of melamine (400 mg/kg), cyanuric acid (400 mg/kg), or melamine and cyanuric acid (400 mg of each compound/kg) daily for 3 days and were euthanatized 1, 3, 6, 10, or 14 days after administration ceased. Fresh, frozen, and formalin-fixed kidneys were examined for crystals. Edible tissues were collected for residue analysis. Crystals were examined for composition via Raman spectroscopy and hydrophilic-interaction liquid chromatography-tandem mass spectrometry. Results--All animals fed the combination of melamine and cyanuric acid developed goldbrown renal crystals arranged in radial spheres (spherulites), similar to those detected in the cat. Spectral analyses of crystals from the cat, pigs, and fish were consistent with melamine-cyanurate complex crystals. Melamine and cyanuric acid residues were identified in edible tissues of fish. Conclusions and Clinical Relevance--Although melamine and cyanuric acid appeared to have low toxicity when administered separately, they induced extensive renal crystal formation when administered together. The subsequent renal failure may be similar to acute uric acid nephropathy in humans, in which crystal spherulites obstruct renal tubules. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Veterinary Research is the property of American Veterinary Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICALS -- Physiological effect
KW - TRIAZINES
KW - KIDNEY stones
KW - KIDNEY diseases
KW - FISH as laboratory animals
KW - SWINE as laboratory animals
KW - URIC acid
N1 - Accession Number: 34215625; Reimschuessel, Renate 1 Gieseker, Charles M. 1 Miller, Ron A. Ward, Jeffrey 1 Boehmer, Jamie 1 Rummel, Nathan 1 Heller, David N. 1 Nochetto, Christina 1 Hemakanthi de Alwis, G. K. 1 Bataller, Neal Andersen, Wendy C. 2 Turnipseed, Sherri B. 2 Karbiwnyk, Christine W. 2 Satzger, R. Duane 3 Crowe, John B. 3 Wilber, Nancy R. 4 Reinhard, Mary K. 5 Roberts, John F. 5 Witkowski, Mark R. 3; Affiliation: 1: Center for Veterinary Medicine, US FDA, 8401 Muirkirk Rd, Laurel, MD 20708 2: Animal Drugs Research Center, US FDA, Denver Federal Center, Bldg 20, W 6th Ave and Kipling Blvd, Denver, CO 80225-0087 3: Forensic Chemistry Center, US FDA, 6751 Steger Dr, Cincinnati, OH 45237 4: Academy Animal Hospital, 4025 N Federal Hwy, Ft Lauderdale, FL 33308 5: Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611; Source Info: Sep2008, Vol. 69 Issue 9, p1217; Subject Term: CHEMICALS -- Physiological effect; Subject Term: TRIAZINES; Subject Term: KIDNEY stones; Subject Term: KIDNEY diseases; Subject Term: FISH as laboratory animals; Subject Term: SWINE as laboratory animals; Subject Term: URIC acid; Number of Pages: 12p; Illustrations: 9 Black and White Photographs, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - Van Dyck, Peter C.
AU - Siahpush, Mohammad
T1 - Racial/Ethnic, Socioeconomic, and Behavioral Determinants of Childhood and Adolescent Obesity in the United States: Analyzing Independent and Joint Associations
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2008/09//
VL - 18
IS - 9
M3 - Article
SP - 682
EP - 695
SN - 10472797
AB - Purpose: This study examines independent and joint associations between several socioeconomic, demographic, and behavioral characteristics and obesity prevalence among 46,707 children aged 10–17 years in the United States. Methods: The 2003 National Survey of Children''s Health was used to calculate obesity prevalence. Logistic regression was used to estimate odds of obesity and adjusted prevalence. Results: Ethnic minority status, non-metropolitan residence, lower socioeconomic status (SES) and social capital, higher television viewing, and higher physical inactivity levels were all independently associated with higher obesity prevalence. Adjusted obesity prevalence varied by age, gender, race/ethnicity, and SES. Compared with affluent white children, the odds of obesity were 2.7, 1.9 and 3.2 times higher for the poor Hispanic, white, and black children, respectively. Hispanic, white, and black children watching television 3 hours or more per day had 1.8, 1.9, and 2.5 times higher odds of obesity than white children who watched television less than 1 hour/day, respectively. Poor children with a sedentary lifestyle had 3.7 times higher odds of obesity than their active, affluent counterparts (adjusted prevalence, 19.8% vs. 6.7%). Conclusions: Race/ethnicity, SES, and behavioral factors are independently related to childhood and adolescent obesity. Joint effects by gender, race/ethnicity, and SES indicate the potential for considerable reduction in the existing disparities in childhood obesity in the United States. [Copyright &y& Elsevier]
AB - Copyright of Annals of Epidemiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBESITY in adolescence
KW - OBESITY in children
KW - OBESITY -- Social aspects
KW - SOCIAL status
KW - BODY mass index
KW - ETHNICITY
KW - TELEVISION viewing
KW - RISK factors
KW - UNITED States
KW - body mass index ( BMI )
KW - Childhood and Adolescent Obesity
KW - Ethnicity
KW - National Center for Health Statistics ( NCHS )
KW - National Health and Nutritional Examination Survey ( NHANES )
KW - National Survey of Children's Health ( NSCH )
KW - Neighborhood Safety
KW - Physical Activity
KW - physical activity ( PA )
KW - Social Capital
KW - Socioeconomic Status
KW - socioeconomic status ( SES )
KW - Television Viewing
KW - United States
N1 - Accession Number: 34297580; Singh, Gopal K. 1; Email Address: gsingh@hrsa.gov Kogan, Michael D. 1 Van Dyck, Peter C. 1 Siahpush, Mohammad 2; Affiliation: 1: From the Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD 2: Department of Health Promotion, Social and Behavioral Health, College of Public Health, University of Nebraska Medical Center, Omaha; Source Info: Sep2008, Vol. 18 Issue 9, p682; Subject Term: OBESITY in adolescence; Subject Term: OBESITY in children; Subject Term: OBESITY -- Social aspects; Subject Term: SOCIAL status; Subject Term: BODY mass index; Subject Term: ETHNICITY; Subject Term: TELEVISION viewing; Subject Term: RISK factors; Subject Term: UNITED States; Author-Supplied Keyword: body mass index ( BMI ); Author-Supplied Keyword: Childhood and Adolescent Obesity; Author-Supplied Keyword: Ethnicity; Author-Supplied Keyword: National Center for Health Statistics ( NCHS ); Author-Supplied Keyword: National Health and Nutritional Examination Survey ( NHANES ); Author-Supplied Keyword: National Survey of Children's Health ( NSCH ); Author-Supplied Keyword: Neighborhood Safety; Author-Supplied Keyword: Physical Activity; Author-Supplied Keyword: physical activity ( PA ); Author-Supplied Keyword: Social Capital; Author-Supplied Keyword: Socioeconomic Status; Author-Supplied Keyword: socioeconomic status ( SES ); Author-Supplied Keyword: Television Viewing; Author-Supplied Keyword: United States; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.annepidem.2008.05.001
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - JM Violanti
AU - Hartley, T.A.
AU - Mnatsakanova, A.
AU - Andrew, M.E.
AU - Burchfiel, C.M.
T1 - Depression And Body Mass Index: A Prospective Analysis
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2008/09//
VL - 18
IS - 9
M3 - Abstract
SP - 731
EP - 732
SN - 10472797
N1 - Accession Number: 34297645; JM Violanti 1 Hartley, T.A. 2 Mnatsakanova, A. 2 Andrew, M.E. 2 Burchfiel, C.M. 2; Affiliation: 1: University at Buffalo, Buffalo, NY 2: National Institute for Occupational Safety and Health, Morgantown, WV; Source Info: Sep2008, Vol. 18 Issue 9, p731; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.annepidem.2008.08.073
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105556987
T1 - Racial/ethnic, socioeconomic, and behavioral determinants of childhood and adolescent obesity in the United States: analyzing independent and joint associations.
AU - Singh GK
AU - Kogan MD
AU - Van Dyck PC
AU - Siahpush M
Y1 - 2008/09//
N1 - Accession Number: 105556987. Language: English. Entry Date: 20090403. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9100013.
KW - Health Behavior
KW - Race Factors
KW - Socioeconomic Factors
KW - Pediatric Obesity -- Risk Factors
KW - Adolescence
KW - Chi Square Test
KW - Child
KW - Confidence Intervals
KW - Female
KW - Life Style, Sedentary
KW - Male
KW - Odds Ratio
KW - Prevalence
KW - United States
KW - Human
SP - 682
EP - 695
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 18
IS - 9
CY - New York, New York
PB - Elsevier Science
AB - Purpose: This study examines independent and joint associations between several socioeconomic, demographic, and behavioral characteristics and obesity prevalence among 46,707 children aged 10DS17 years in the United States.Methods: The 2003 National Survey of Children's Health was used to calculate obesity prevalence. Logistic regression was used to estimate odds of obesity and adjusted prevalence.Results: Ethnic minority status, non-metropolitan residence, lower socioeconomic status (SES) and social capital, higher television viewing, and higher physical inactivity levels were all independently associated with higher obesity prevalence. Adjusted obesity prevalence varied by age, gender, race/ethnicity, and SES. Compared with affluent white children, the odds of obesity were 2.7, 1.9 and 3.2 times higher for the poor Hispanic, white, and black children, respectively. Hispanic, white, and black children watching television 3 hours or more per day had 1.8, 1.9, and 2.5 times higher odds of obesity than white children who watched television less than 1 hour/day, respectively. Poor children with a sedentary lifestyle had 3.7 times higher odds of obesity than their active, affluent counterparts (adjusted prevalence, 19.8% vs. 6.7%).Conclusions: Race/ethnicity, SES, and behavioral factors are independently related to childhood and adolescent obesity. Joint effects by gender, race/ethnicity, and SES indicate the potential for considerable reduction in the existing disparities in childhood obesity in the United States.
SN - 1047-2797
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857; gsingh@hrsa.gov
U2 - PMID: 18794009.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Volokhov, Dmitriy V.
AU - Hyesuk Kong
AU - George, Joseph
AU - Anderson, Christine
AU - Chizhikov, Vladimir E.
T1 - Biological Enrichment of Mycoplasma Agents by Cocultivation with Permissive Cell Cultures.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/09//
VL - 74
IS - 17
M3 - Article
SP - 5383
EP - 5391
SN - 00992240
AB - In this study, we describe our results on the evaluation of the ability of different permissive mammalian cell lines to support the biological enrichment of mycoplasma species known to be bacterial contaminants of cell substrates. The study showed that this approach is able to significantly improve the efficiency of mycoplasma detection based on nucleic acid testing or biochemical technologies (e.g., MycoAlert mycoplasma detection). Of 10 different cell lines (Vero, MDBK, HEK-293, Hep-G2, CV-1, EBTr, WI-38, R9ab, MDCK, and High Five) used in the study, only MDCK cell culture was found to support the efficient growth of all the tested mycoplasmas (Mycoplasma arginini, M. bovis, M. fermentans, M. gallinaceurn, M. gallisepticum, M. synoviae, M. hominis, M. hyorhinis, M. orale, M. salivarium, and Acholeplasma laidlawii) known to be most frequently associated with contamination of cell substrates and cell lines in research laboratories or manufacturing facilities. The infection of MDCK cells with serial dilutions of each mycoplasma species demonstrated that these common cell line contaminants can be detected reliably after 7-day enrichment in MDCK cell culture at contamination levels of 0.05 to 0.25 CFU/ml. The High Five insect cell line was also found to be able to support the efficient growth of most mycoplasma species tested, except for M. hyorhinis strain DBS1050. However, mycoplasma growth in insect cell culture was demonstrated to be temperature dependent, and the most efficient growth was observed when the incubation temperature was increased from 28°C to between 35 and 37°C. We believe that this type of mycoplasma enrichment is one of the most promising approaches for improving the purity and safety testing of cell substrates and other cell-derived biologics and pharmaceuticals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOPLASMA
KW - BACTERIA
KW - POLLUTANTS
KW - NUCLEIC acids
KW - MICROBIAL ecology
KW - MICROBIOLOGY
N1 - Accession Number: 34368463; Volokhov, Dmitriy V. 1; Email Address: dmitriy.volokhov@fda.hhs.gov Hyesuk Kong 1 George, Joseph 1 Anderson, Christine 1 Chizhikov, Vladimir E. 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, Maiyland 20852; Source Info: Sep2008, Vol. 74 Issue 17, p5383; Subject Term: MYCOPLASMA; Subject Term: BACTERIA; Subject Term: POLLUTANTS; Subject Term: NUCLEIC acids; Subject Term: MICROBIAL ecology; Subject Term: MICROBIOLOGY; Number of Pages: 9p; Illustrations: 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1128/AEM.00720-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105690651
T1 - Work schedule differences in sleep problems of nursing home caregivers.
AU - Takahashi M
AU - Iwakiri K
AU - Sotoyama M
AU - Higuchi S
AU - Kiguchi M
AU - Hirata M
AU - Hisanaga N
AU - Kitahara T
AU - Taoda K
AU - Nishiyama K
Y1 - 2008/09//
N1 - Accession Number: 105690651. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0261412.
KW - Caregivers -- Statistics and Numerical Data
KW - Nursing Homes -- Administration
KW - Sleep Disorders, Circadian Rhythm -- Epidemiology
KW - Work -- Psychosocial Factors
KW - Adult
KW - Caregivers -- Psychosocial Factors
KW - Cross Sectional Studies
KW - Female
KW - Insomnia -- Epidemiology
KW - Insomnia -- Etiology
KW - Japan
KW - Male
KW - Nursing Homes -- Statistics and Numerical Data
KW - Occupational Health
KW - Odds Ratio
KW - Personnel Staffing and Scheduling
KW - Questionnaires
KW - Sleep Disorders, Circadian Rhythm -- Complications
KW - Human
SP - 597
EP - 604
JO - Applied Ergonomics
JF - Applied Ergonomics
JA - APPL ERGON
VL - 39
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0003-6870
AD - National Institute of Occupational Safety and Health, 6-21-1, Nagao, Tama-ku, Kawasaki 214-8585, Japan.
U2 - PMID: 18281013.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jones, Brian T.
AU - Ham, Jason E.
T1 - α-Terpineol reactions with the nitrate radical: Rate constant and gas-phase products
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2008/09//
VL - 42
IS - 27
M3 - Article
SP - 6689
EP - 6698
SN - 13522310
AB - The bimolecular rate constant of (16±4)×10−12 cm3 molecule−1 s−1 was measured using the relative rate technique for the reaction of the nitrate radical (NO3 x3b1;-terpineol (2-(4-methyl-1-cyclohex-3-enyl)propan-2-ol) at 297±3K and 1atmosphere total pressure. To more clearly define part of α-terpineol''s indoor environment degradation mechanism, the products of α-terpineol+NO3 were investigated. The identified reaction products were: acetone, glyoxal (HC(lyph name="dbnd" />O)H), and methylglyoxal (CH3C(lyph name="dbnd" />O)H). The use of derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) were used to propose the other major reaction products: 6-hydroxyhept-5-en-2-one, 4-(1-hydroxy-1-methylethyl)-1-methyl-2-oxocyclohexyl nitrate, 5-(1-hydroxy-1-methylethyl)-2-oxocyclohexyl nitrate, 1-formyl-5-hydroxy-4-(hydroxymethyl)-1,5-dimethylhexyl nitrate, and 1,4-diformyl-5-hydroxy-1,5-dimethylhexyl nitrate. The elucidation of these products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible α-terpineol+NO3 mechanisms based on previously published volatile organic compound+NO3 e mechanisms. The additional gas-phase products (2,6,6-trimethyltetrahydro-2H-pyran-2,5-dicarbaldehyde and 2,2-dimethylcyclohexane-1,4-dicarbaldehyde) are proposed to be the result of cyclization through a reaction intermediate. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nitrates -- Environmental aspects
KW - RESEARCH
KW - Environmental degradation -- Research
KW - Acetone
KW - Mass spectrometry
KW - Volatile organic compounds -- Environmental aspects
KW - Nitrates -- Spectra
KW - Atmospheric pressure -- Measurement
KW - Atmospheric pressure
KW - Glyoxal
KW - α-Terpineol
KW - Kinetics
KW - Nitrate radical
KW - Oxygenated organic compounds
KW - Reaction products
N1 - Accession Number: 34203180; Jones, Brian T. 1; Ham, Jason E. 2; Email Address: bvo2@cdc.gov; Affiliations: 1: Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7078, USA; 2: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Sep2008, Vol. 42 Issue 27, p6689; Thesaurus Term: Nitrates -- Environmental aspects; Thesaurus Term: RESEARCH; Thesaurus Term: Environmental degradation -- Research; Thesaurus Term: Acetone; Thesaurus Term: Mass spectrometry; Thesaurus Term: Volatile organic compounds -- Environmental aspects; Subject Term: Nitrates -- Spectra; Subject Term: Atmospheric pressure -- Measurement; Subject Term: Atmospheric pressure; Subject Term: Glyoxal; Author-Supplied Keyword: α-Terpineol; Author-Supplied Keyword: Kinetics; Author-Supplied Keyword: Nitrate radical; Author-Supplied Keyword: Oxygenated organic compounds; Author-Supplied Keyword: Reaction products; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.atmosenv.2008.04.017
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105658620
T1 - How does your hospital measure up?
AU - Rapp MT
Y1 - 2008/09//2008 Sep
N1 - Accession Number: 105658620. Language: English. Entry Date: 20081003. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. Special Interest: Consumer Health. NLM UID: 9891730.
KW - Hospitals
KW - Quality of Health Care
KW - Heart Failure
KW - Information Resources
KW - Myocardial Infarction
KW - Pneumonia
KW - Surgery, Operative
SP - 9
EP - 11
JO - Bottom Line Health
JF - Bottom Line Health
JA - BOTTOM LINE HEALTH
VL - 22
IS - 9
CY - Greenwich, Connecticut
PB - Health Confidential
AB - New ratings can help you find the best care available.
SN - 1092-0129
AD - Director, Quality Measurement and Health Assessment Group, Office of Clinical Standards and Quality, US Department of Health and Human Services Centers for Medicare and Medicaid Services, Baltimore
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stamatas, G. N.
AU - Zmudzka, B. Z.
AU - Kollias, N.
AU - Beer, J. Z.
T1 - In vivo measurement of skin erythema and pigmentation: new means of implementation of diffuse reflectance spectroscopy with a commercial instrument.
JO - British Journal of Dermatology
JF - British Journal of Dermatology
Y1 - 2008/09//
VL - 159
IS - 3
M3 - Article
SP - 683
EP - 690
PB - Wiley-Blackwell
SN - 00070963
AB - Background Various physical, chemical and biological insults, including exposure to ultraviolet (UV) radiation, cause erythema and change in pigmentation in human skin. These reactions provide an important measure of the cutaneous response to the insult. Objectives To present a new implementation of a method for objective in vivo measurement of erythema and pigmentation. Methods The method is based on acquisition of reflectance spectra in the visible range using a commercially available spectrophotometer. The probe of this instrument incorporates an integrating sphere that captures the light remitted from the skin in a wide range of angles. We corrected the acquired reflectance spectra for the contribution of specular reflections by an amount given by the Fresnel equation and verified this correction experimentally. This correction is particularly important when measurements are performed on heavily pigmented skin. The corrected reflectance spectra are then transformed into absorbance spectra. To analyse these spectra, we developed an algorithm which can be used to calculate apparent concentrations of oxyhaemoglobin, deoxyhaemoglobin and melanin. This method was tested in clinical studies of skin reactions induced by exposure to UV radiation. These experiments involved three groups of subjects with progressively darker complexion (constitutive pigmentation). Each group consisted of 10 subjects. Erythema was measured 1 day after UV exposure, and pigmentation (melanin content) 1 week later. Results Distinct apparent absorbance spectra were obtained for dark, intermediate and fair skin. There was good agreement between reconstructed spectra and experimental data at relevant wavelengths. Difference absorption spectra were able to show the dose dependence of UV-induced responses, and erythema and pigmentation values obtained by the spectroscopic method showed good correlation with those derived by subjective visual grading. Conclusions The results demonstrate that the presented methodology provides an objective noninvasive way of measuring UV-induced reactions independently of the level of constitutive pigmentation. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERYTHEMA
KW - REFLECTANCE spectroscopy
KW - HUMAN skin color
KW - MELANINS
KW - ULTRAVIOLET radiation
KW - ABSORPTION spectra
KW - erythema
KW - pigmentation
KW - spectroscopy
KW - ultraviolet
N1 - Accession Number: 33865457; Stamatas, G. N. 1; Email Address: gstamat@cpcus.jnj.com Zmudzka, B. Z. 2 Kollias, N. 3 Beer, J. Z. 2; Affiliation: 1: Skin Care Research Institute, Johnson & Johnson Consumer France SAS, 92787 Issy-Les-Moulineaux, France 2: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, U.S.A. 3: Methods & Models Development, CPPW, Johnson & Johnson Consumer Co., Skillman, NJ, U.S.A.; Source Info: Sep2008, Vol. 159 Issue 3, p683; Subject Term: ERYTHEMA; Subject Term: REFLECTANCE spectroscopy; Subject Term: HUMAN skin color; Subject Term: MELANINS; Subject Term: ULTRAVIOLET radiation; Subject Term: ABSORPTION spectra; Author-Supplied Keyword: erythema; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: spectroscopy; Author-Supplied Keyword: ultraviolet; Number of Pages: 8p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2133.2008.08642.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Llena, C.
AU - Forner, L.
T1 - Dietary Habits in a Child Population in Relation to Caries Experience.
JO - Caries Research
JF - Caries Research
Y1 - 2008/09//
VL - 42
IS - 5
M3 - Article
SP - 387
EP - 393
SN - 00086568
AB - Sugar consumption in Spain has remained constant at around 80 g/day since the 1970s. Although intake as sugar has fallen considerably, to around 13.5 g/person/day, the intake in processed foods has risen. Meanwhile, caries prevalence is falling or stabilizing. This situation is common in developed countries, where the impact of diet on caries has altered, probably through greater use of fluoridated products. In the Valencia region, children habitually eat sugary foods and drinks and snacks that contain starches or sugars and starches. The present study analyzed the association between caries experience, quantified as the sum of the dfs and DMFS indices, and the consumption of cariogenic foods in a population of children between the ages of 6 and 10 with low caries prevalence. A self-administered food consumption frequency questionnaire filled in by the parents was used to evaluate how often the foods on the list were consumed by the children, which was then related to their caries experience. Sweet snacks, industrial bread and soft drink consumption showed a positive association with caries while cheese and nuts showed a negative association. Logistic regression suggested that consuming sugary liquids and foods rich in semi-hydrolyzed starch increased the chances of suffering caries by 1.05 and 1.13 respectively. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Caries Research is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUGAR
KW - FOOD consumption
KW - DENTAL caries
KW - VALENCIA (Spain : Region)
KW - SPAIN
KW - Artificial sweeteners
KW - Carbohydrates
KW - Caries
KW - Diet
KW - Hidden sugars in diet
KW - Sugary drinks
N1 - Accession Number: 34535777; Llena, C. 1,2; Email Address: llena@uv.es Forner, L. 2; Affiliation: 1: Primary Care in Dental Public Health Service, Department 9, University of Valencia, Valencia, Spain 2: Department of Stomatology, University of Valencia, Valencia, Spain; Source Info: 2008, Vol. 42 Issue 5, p387; Subject Term: SUGAR; Subject Term: FOOD consumption; Subject Term: DENTAL caries; Subject Term: VALENCIA (Spain : Region); Subject Term: SPAIN; Author-Supplied Keyword: Artificial sweeteners; Author-Supplied Keyword: Carbohydrates; Author-Supplied Keyword: Caries; Author-Supplied Keyword: Diet; Author-Supplied Keyword: Hidden sugars in diet; Author-Supplied Keyword: Sugary drinks; NAICS/Industry Codes: 311314 Cane Sugar Manufacturing; NAICS/Industry Codes: 311310 Sugar manufacturing; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1159/000154784
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105558393
T1 - Dietary habits in a child population in relation to caries experience.
AU - Llena C
AU - Forner F
AU - Llena, C
AU - Forner, L
Y1 - 2008/09//
N1 - Accession Number: 105558393. Language: English. Entry Date: 20090206. Revision Date: 20161129. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Special Interest: Dental Care. Instrumentation: Decayed, Missing, and Filled Surfaces (DMFS) Index. NLM UID: 0103374.
KW - Clinical Assessment Tools
KW - Food Habits
KW - Bread
KW - Candy
KW - Carbonated Beverages
KW - Cariogenic Agents -- Administration and Dosage
KW - Cariostatic Agents -- Therapeutic Use
KW - Cheese
KW - Child
KW - Cross Sectional Studies
KW - Dairy Products
KW - Dental Caries -- Classification
KW - Dental Restoration, Permanent
KW - Dentifrices -- Therapeutic Use
KW - Dietary Carbohydrates -- Administration and Dosage
KW - Dietary Sucrose -- Administration and Dosage
KW - Female
KW - Fluorides -- Therapeutic Use
KW - Fruit
KW - Glucans -- Administration and Dosage
KW - Male
KW - Nuts
KW - Spain
KW - Toothbrushing
KW - Human
SP - 387
EP - 393
JO - Caries Research
JF - Caries Research
JA - CARIES RES
VL - 42
IS - 5
PB - Karger AG
AB - Sugar consumption in Spain has remained constant at around 80 g/day since the 1970s. Although intake as sugar has fallen considerably, to around 13.5 g/person/day, the intake in processed foods has risen. Meanwhile, caries prevalence is falling or stabilizing. This situation is common in developed countries, where the impact of diet on caries has altered, probably through greater use of fluoridated products. In the Valencia region, children habitually eat sugary foods and drinks and snacks that contain starches or sugars and starches. The present study analyzed the association between caries experience, quantified as the sum of the dfs and DMFS indices, and the consumption of cariogenic foods in a population of children between the ages of 6 and 10 with low caries prevalence. A self-administered food consumption frequency questionnaire filled in by the parents was used to evaluate how often the foods on the list were consumed by the children, which was then related to their caries experience. Sweet snacks, industrial bread and soft drink consumption showed a positive association with caries while cheese and nuts showed a negative association. Logistic regression suggested that consuming sugary liquids and foods rich in semi-hydrolyzed starch increased the chances of suffering caries by 1.05 and 1.13 respectively.
SN - 0008-6568
AD - Primary Care in Dental Public Health Service, Department 9, University of Valencia, Valencia, Spain
AD - University of Valencia, Valencia, Spain
U2 - PMID: 18781067.
DO - 10.1159/000154784
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105607919
T1 - Pharmacogenomics: the key to improved drug therapy in transplant patients.
AU - Burckart GJ
Y1 - 2008/09//2008 Sep
N1 - Accession Number: 105607919. Language: English. Entry Date: 20090220. Revision Date: 20150711. Publication Type: Journal Article; algorithm; review; tables/charts. Journal Subset: Allied Health; Biomedical; USA. Special Interest: Laboratory Diagnosis. NLM UID: 8100174.
KW - Genomics
KW - Organ Transplantation
KW - Pharmacy and Pharmacology
KW - Immunosuppressive Agents
KW - Polymorphism, Genetic
SP - 411
EP - 422
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
JA - CLIN LAB MED
VL - 28
IS - 3
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - The current success in organ transplantation has been brought about by immunosuppressive therapy. Improvements in transplant outcome using these drugs have stalled, and an understanding of the pharmacogenomics of immunosuppressive dosing and response holds the greatest promise for advancing the use of these agents. © 2008 Elsevier Inc. All rights reserved.
SN - 0272-2712
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Building 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. gilbert.burckart@fda.hhs.gov
U2 - PMID: 19028260.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Karacan, C.Ö.
T1 - Evaluation of the relative importance of coalbed reservoir parameters for prediction of methane inflow rates during mining of longwall development entries
JO - Computers & Geosciences
JF - Computers & Geosciences
Y1 - 2008/09//
VL - 34
IS - 9
M3 - Article
SP - 1093
EP - 1114
SN - 00983004
AB - Abstract: This study presents a reservoir modeling approach to investigate the relative effects of different coalbed parameters on the migration of methane into development entries. A base coalbed reservoir model of a three-entry development section, where grids were dynamically controlled to simulate the advance of mining at a constant section advance rate, was created and calibrated for a Pittsburgh Coalbed mine in the Southwestern Pennsylvania section of the Northern Appalachian Basin. The values of coalbed parameters were varied to evaluate their effects on predicted methane emissions for various development distances. The results of these parametric simulations were then used to derive linear expressions relating these parameters to methane emissions into the workings. These models were analyzed to assess their significance and adequacy for predictive purposes. This work shows that coupling reservoir simulations with linear modeling yield a technique that can be applicable to different coalbeds. The reservoir parameters used by the linear models (coalbed thickness, pressure, sorption time constant, Langmuir parameters, permeability) can be determined by running relatively simple laboratory tests, such as adsorption equilibrium and permeability determination, on coal samples obtained either from the mining operation or from the exploratory boreholes drilled ahead of mining. [Copyright &y& Elsevier]
AB - Copyright of Computers & Geosciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUID dynamics
KW - MATHEMATICAL statistics
KW - HYDROGEOLOGY
KW - MATHEMATICAL models
KW - LINEAR models (Statistics)
KW - FLUID mechanics
KW - Coalbed reservoir modeling
KW - Development mining
KW - Mine safety
KW - Multiple regression analysis
KW - Reservoir simulation
KW - Underground mining
N1 - Accession Number: 32756528; Karacan, C.Ö. 1; Email Address: cok6@cdc.gov; Affiliation: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA; Source Info: Sep2008, Vol. 34 Issue 9, p1093; Subject Term: FLUID dynamics; Subject Term: MATHEMATICAL statistics; Subject Term: HYDROGEOLOGY; Subject Term: MATHEMATICAL models; Subject Term: LINEAR models (Statistics); Subject Term: FLUID mechanics; Author-Supplied Keyword: Coalbed reservoir modeling; Author-Supplied Keyword: Development mining; Author-Supplied Keyword: Mine safety; Author-Supplied Keyword: Multiple regression analysis; Author-Supplied Keyword: Reservoir simulation; Author-Supplied Keyword: Underground mining; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.cageo.2007.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luecke, Richard H.
AU - Pearce, Bruce A.
AU - Wosilait, Walter D.
AU - Doerge, Daniel R.
AU - Slikker, William
AU - Young, John F.
T1 - Windows based general PBPK/PD modeling software
JO - Computers in Biology & Medicine
JF - Computers in Biology & Medicine
Y1 - 2008/09//
VL - 38
IS - 9
M3 - Article
SP - 962
EP - 978
SN - 00104825
AB - Abstract: A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues. This Windows based program is actually four linked PBPK models with each PBPK model acting independently or totally integrated with the others through metabolism by first order or Michaelis–Menten kinetics. Data fitting is accomplished by a weighted least square regression algorithm. The model includes linkages for the simulation of pharmacodynamic (PD) effects. [Copyright &y& Elsevier]
AB - Copyright of Computers in Biology & Medicine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - POSTNATAL care
KW - REGRESSION analysis
KW - WINDOWS (Graphical user interfaces)
KW - LEAST squares
KW - COMPUTER programming
KW - Dog
KW - Human
KW - Mouse
KW - PBPK/PD
KW - Pharmacodynamic model
KW - Pharmacokinetic model
KW - Postnatal growth
KW - Rat
KW - Windows software
N1 - Accession Number: 34202400; Luecke, Richard H. 1 Pearce, Bruce A. 2 Wosilait, Walter D. 3 Doerge, Daniel R. 4 Slikker, William 5 Young, John F. 6; Email Address: john.young@fda.hhs.gov; Affiliation: 1: Department of Chemical Engineering, University of Missouri – Columbia, Columbia, MO 65231, USA 2: Office of Information Technology, National Center for Toxicological Research/FDA/DHHS, Jefferson, AR 72079, USA 3: Department of Pharmacology, University of Missouri – Columbia, Columbia, MO 65231, USA 4: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA/DHHS, Jefferson, AR 72079, USA 5: Office of the Director, National Center for Toxicological Research/FDA/DHHS, Jefferson, AR 72079, USA 6: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research/FDA/DHHS, Jefferson, AR 72079, USA; Source Info: Sep2008, Vol. 38 Issue 9, p962; Subject Term: PHARMACOKINETICS; Subject Term: POSTNATAL care; Subject Term: REGRESSION analysis; Subject Term: WINDOWS (Graphical user interfaces); Subject Term: LEAST squares; Subject Term: COMPUTER programming; Author-Supplied Keyword: Dog; Author-Supplied Keyword: Human; Author-Supplied Keyword: Mouse; Author-Supplied Keyword: PBPK/PD; Author-Supplied Keyword: Pharmacodynamic model; Author-Supplied Keyword: Pharmacokinetic model; Author-Supplied Keyword: Postnatal growth; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Windows software; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.compbiomed.2008.06.001
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Baron, Samuel
AU - Poast, Joyce
AU - Suzuki, Fujio
AU - Kobayashi, Makiko
AU - Clouse, Kathleen
AU - Bacot, Sylvia
AU - Tiffany, Linda
AU - Lankford, Carla
AU - Boekhoudt, Gunther
AU - Morrow, Angel
AU - Fey, Samuel
AU - Schmeisser, Hana
AU - Bekisz, Joseph
AU - Zoon, Kathryn
T1 - 331 Innate immunity: Preclinical study of eradication of tumor cells by IFN-activated monocytes in vitro and in vivo
JO - Cytokine
JF - Cytokine
Y1 - 2008/09//
VL - 43
IS - 3
M3 - Abstract
SP - 322
EP - 322
SN - 10434666
N1 - Accession Number: 34302088; Baron, Samuel 1,2,3 Poast, Joyce 1 Suzuki, Fujio 2 Kobayashi, Makiko 2 Clouse, Kathleen 4 Bacot, Sylvia 4 Tiffany, Linda 4 Lankford, Carla 4 Boekhoudt, Gunther 4 Morrow, Angel 3 Fey, Samuel 3 Schmeisser, Hana 3 Bekisz, Joseph 3 Zoon, Kathryn 3; Affiliation: 1: University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, TX, USA 2: University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX, USA 3: NIAID, NIH, Bethesda, MD, USA 4: Food and Drug Administration, Bethesda, MD, USA; Source Info: Sep2008, Vol. 43 Issue 3, p322; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.cyto.2008.07.415
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Dreyer, Nancy A.1,2, ndreyer@outcome.com
AU - Sheth, Neha3
AU - Trontell, Anne4
AU - Gliklich, Richard E.2,5
T1 - Good Practices for Handling Adverse Events Detected Through Patient Registries.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2008/09//
Y1 - 2008/09//
VL - 42
IS - 5
CP - 5
M3 - Article
SP - 421
EP - 428
SN - 00928615
AB - As the number of patient registries for marketed products increases, it is important for investigators and manufacturers to understand the public health responsibilities and potential regulatory requirements for reporting adverse drug events (AEs). Requirements for reporting AEs will vary depending upon sponsorship of the registry (regulated versus non-regulated industry). If registries are sponsored or supported by a regulated entity and AEs are noted in the course of a registry's direct patient contact concerning a marketed drug product, the seriousness, expectedness, and possible relationship of the AE to the drug product should be assessed. Recommendations are presented for good registry practices for detecting, processing, and reporting adverse events. [ABSTRACT FROM AUTHOR]
KW - Recording & registration
KW - Public health
KW - Drugs -- Side effects -- Reporting
KW - Trade regulation
KW - Pharmaceutical industry
KW - Regulated industries
KW - Adverse event reporting
KW - Registries
KW - SAE
N1 - Accession Number: 34457863; Authors: Dreyer, Nancy A. 1,2 Email Address: ndreyer@outcome.com; Sheth, Neha 3; Trontell, Anne 4; Gliklich, Richard E. 2,5; Affiliations: 1: Chief of Scientific Affairs and Project Director, Outcome Sciences Inc.; 2: Outcome DECIDE Center, Cambridge, Massachusetts; 3: Senior Director Safety and Risk Management, Pfizer, Ann Arbor, Michigan; 4: Program Director, Centers for Education and Research in Therapeutics, Agency for Healthcare Research and Quality, Rockville, Maryland; 5: President and Principal Investigator, Outcome Sciences Inc.; Subject: Recording & registration; Subject: Public health; Subject: Drugs -- Side effects -- Reporting; Subject: Trade regulation; Subject: Pharmaceutical industry; Subject: Regulated industries; Author-Supplied Keyword: Adverse event reporting; Author-Supplied Keyword: Registries; Author-Supplied Keyword: SAE; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY -
AU - Young-Ok Kim1
AU - In-Seek Park2
AU - So-Young Wang3
AU - Hwa-Kyung Lim3
AU - So Hen Kim2
AU - Joe Hyeun Lee3
AU - Mi Jeong Kim2
AU - Kyung-Eun Youn3
AU - Yun Hee Lee3
AU - Su-Jung Lee4
AU - Dang Sup Kim5
AU - Inkyu Kim1
AU - Bo-Kyung Choi6, hercbk@kfda.go.kr
T1 - Development and Establishment of Good Review Practices for Drug Products in Korea.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2008/09//
Y1 - 2008/09//
VL - 42
IS - 5
CP - 5
M3 - Article
SP - 487
EP - 491
SN - 00928615
AB - Good review practices (GRP) for drug products are a system to ensure the consistency, transparency, fairness, and objectivity of the review process. To this end, the standardized guidelines on process and procedures for the review of drag products were developed for efficient conduct of the review process, and ongoing training activities were conducted to improve the expertise level of reviewers. Since the introduction of the GRP system in 2004, the Korea Food and Drug Administration has initiated various research activities to reflect the results in the review process. Major accomplishments arising from the introduction of the GRP are as follows: (1) standardized review forms for various review areas and guidelines on considerations in reviewing drug products were developed to improve the efficiency and effectiveness of the review process; (2) the review-related regulations were newly developed or revised and guidelines were published to ensure the consistency and fairness of the review process; (3) the procedure for disclosure of review results was developed and various data and information have been disclosed to the public to improve the transparency and reliability of the review process and results; and (4) training programs for reviewers have been developed and implemented to improve the expertise level of reviewers and ensure reliable review results. In addition, a road map for the GRP system was developed, which has been systematically executed to improve the quality of the review process and confidence in the review results. [ABSTRACT FROM AUTHOR]
KW - Drug approval
KW - Pharmaceutical policy
KW - Guidelines
KW - Standards
KW - Fairness
KW - Korea
KW - Good review practices
KW - Korea Food and Drug Administration
KW - Review template
KW - Standardized guidelines
KW - Training programs
N1 - Accession Number: 34457869; Authors: Young-Ok Kim 1; In-Seek Park 2; So-Young Wang 3; Hwa-Kyung Lim 3; So Hen Kim 2; Joe Hyeun Lee 3; Mi Jeong Kim 2; Kyung-Eun Youn 3; Yun Hee Lee 3; Su-Jung Lee 4; Dang Sup Kim 5; Inkyu Kim 1; Bo-Kyung Choi 6 Email Address: hercbk@kfda.go.kr; Affiliations: 1: Team Leader, Korea Food and Drug Administration, Seoul, Korea; 2: Team Leader, Senior Reviewer Korea Food and Drug Administration, Seoul, Korea; 3: Reviewer, Korea Food and Drug Administration, Seoul, Korea; 4: Deputy Team Leader, Senior Reviewer Korea Food and Drug Administration, Seoul, Korea; 5: Director, Korea Food and Drug Administration, Seoul, Korea; 6: Team Leader, Drug Evaluation Department, Pharmaceuticals Headquarters, Korea Food and Drug Administration, Seoul, Korea; Subject: Drug approval; Subject: Pharmaceutical policy; Subject: Guidelines; Subject: Standards; Subject: Fairness; Subject: Korea; Author-Supplied Keyword: Good review practices; Author-Supplied Keyword: Korea Food and Drug Administration; Author-Supplied Keyword: Review template; Author-Supplied Keyword: Standardized guidelines; Author-Supplied Keyword: Training programs; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Charts; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Hausner, Elizabeth
AU - Fiszman, Monica L.
AU - Hanig, Joseph
AU - Harlow, Patricia
AU - Zornberg, Gwen
AU - Sobel, Solomon
T1 - Long-Term Consequences of Drugs on the Paediatric Cardiovascular System.
JO - Drug Safety
JF - Drug Safety
Y1 - 2008/09//
VL - 31
IS - 12
M3 - Article
SP - 1083
EP - 1096
PB - Springer Science & Business Media B.V.
SN - 01145916
AB - Many pharmacological and toxicological actions of drugs in children cannot be fully predicted from adult clinical experience or from standard non-clinical toxicology studies. Numerous drugs have direct or indirect pharmacological effects on the heart and are prescribed for children of all ages. Toxicity or secondary effects may be immediate or delayed for years after drug exposure has ceased. Originally, the aim of this review was to compile information on the effect of specific drugs on the post-natal development of the cardiovascular system and to examine long-term follow-up of the use of cardio-active drugs in children. The limited database of published information caused the original question to evolve into an examination of the medical literature for three areas of information: (i) whether vulnerable developmental windows have been identified that reflect the substantial functional development that the cardiovascular system undergoes after birth; (ii) what is known about pharmacological perturbation of development; and (iii) what the likelihood is of drug exposure during childhood. We examined different scenarios for exposure including random, isolated exposure, conditions historically associated with adults, primary or secondary cardiac disease, psychiatric and neurological conditions, asthma, cancer and HIV. Except for random, isolated drug exposures, each category of possible exposure contained numerous drugs known to have either primary or secondary effects on the cardiovascular system or to influence factors associated with atherosclerosis. It is likely that a significant number of children will be prescribed drugs having either direct or indirect effects upon the immature cardiovascular system. A confounding factor is the simultaneous use of over-the-counter medications and herbal or nutraceutical preparations that a patient, parent or guardian does not mention to a prescribing physician. Metabolism is also important in assessing drug effects in children. Differences in body water : body fat ratio, age-related gastrointestinal absorption, distribution, excretion, renal function and drug metabolizing capabilities make it possible for children to have a different metabolite profile for a drug compared with adults. There is little examination of drug effects on the interdependent processes of cardiac maturation and less examination of metabolite effects. It is difficult to identify delayed toxicities in children as these adverse events may take years to manifest with many patients lost to follow-up. Clearly this is an area of study where intermediate endpoints and surrogate markers would be of great benefit. Pharmacogenomics may he useful in providing markers of increased risk or susceptibility. A perspective must he kept in balancing the possibility of a problem with the very real benefits that many children experience from the use of these pharmaceuticals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Safety is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Physiological effect
KW - PEDIATRIC cardiology
KW - PEDIATRIC pharmacology
KW - METABOLISM
KW - PHYSICIAN & patient
KW - MEDICAL care
KW - PUBLIC health
KW - PHARMACEUTICAL industry
KW - PHARMACEUTICAL research
N1 - Accession Number: 37706035; Hausner, Elizabeth 1 Fiszman, Monica L. 1 Hanig, Joseph 1 Harlow, Patricia 1 Zornberg, Gwen 1 Sobel, Solomon 1; Affiliation: 1: Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: 2008, Vol. 31 Issue 12, p1083; Subject Term: DRUGS -- Physiological effect; Subject Term: PEDIATRIC cardiology; Subject Term: PEDIATRIC pharmacology; Subject Term: METABOLISM; Subject Term: PHYSICIAN & patient; Subject Term: MEDICAL care; Subject Term: PUBLIC health; Subject Term: PHARMACEUTICAL industry; Subject Term: PHARMACEUTICAL research; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 14p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pacurari, Maricica
AU - Xuejun J. Yin
AU - Jinshun Zhao
AU - Ming Ding
AU - Leonard, Steve S.
AU - Schwegler-Berry, Diane
AU - Ducatman, Barbara S.
AU - Sbarra, Deborah
AU - Hoover, Mark D.
AU - Castranova, Vincent
AU - Vallyathan, Val
T1 - Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/09//
VL - 116
IS - 9
M3 - Article
SP - 1211
EP - 1217
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Single-wall carbon nanotubes (SWCNTs), with their unique physicochemical and mechanical properties, have many potential new applications in medicine and industry. There has been great concern subsequent to preliminary investigations of the toxicity, biopersistence, pathogenicity, and ability of SWCNTs to translocate to subpleural areas. These results compel studies of potential interactions of SWCNTs with mesothelial cells. OBJECTIVE: Exposure to asbestos is the primary cause of malignant mesothelioma in 80--90% of individuals who develop the disease. Because the mesothelial cells are the primary target cells of asbestos-induced molecular changes mediated through an oxidant-linked mechanism, we used normal mesothelial and malignant mesothelial cells to investigate alterations in molecular signaling in response to a commercially manufactured SWCNT. METHODS: In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species (ROS) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 (PARP-1), stimulation of extracellular signal-regulated kinase (ERKs), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor κB (NF-κB), and protein serine-threonine kinase (Akt). RESULTS: Exposure to SWCNTs induced ROS generation, increased cell death, enhanced DNA damage and H2AX phosphorylation, and activated PARP, AP-1, NF-κB, p38, and Akt in a dose-dependent manner. These events recapitulate some of the key molecular events involved in mesothelioma development associated with asbestos exposure. CONCLUSIONS: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Toxicity testing
KW - DNA damage
KW - Carbon nanotubes
KW - Toxicological interactions
KW - Mesothelioma
KW - Asbestos
KW - Cells
KW - Oxidative stress
KW - asbestos
KW - cancer
KW - carbon nanotubes
KW - cell injury
KW - mesothelioma
KW - nanoparticles
N1 - Accession Number: 34379496; Pacurari, Maricica 1; Xuejun J. Yin 2; Jinshun Zhao 1; Ming Ding 1; Leonard, Steve S. 1; Schwegler-Berry, Diane 1; Ducatman, Barbara S. 2; Sbarra, Deborah 3; Hoover, Mark D. 3; Castranova, Vincent 1; Vallyathan, Val 1; Email Address: vav1@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Department of Pathology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA; 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Sep2008, Vol. 116 Issue 9, p1211; Thesaurus Term: RESEARCH; Thesaurus Term: Toxicity testing; Thesaurus Term: DNA damage; Subject Term: Carbon nanotubes; Subject Term: Toxicological interactions; Subject Term: Mesothelioma; Subject Term: Asbestos; Subject Term: Cells; Subject Term: Oxidative stress; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: cancer; Author-Supplied Keyword: carbon nanotubes; Author-Supplied Keyword: cell injury; Author-Supplied Keyword: mesothelioma; Author-Supplied Keyword: nanoparticles; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 7p; Illustrations: 2 Diagrams, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stellman, Jeanne Mager
AU - Smith, Rebecca P.
AU - Katz, Craig L.
AU - Sharma, Vansh
AU - Charney, Dennis S.
AU - Herbert, Robin
AU - Moline, Jacqueline
AU - Luft, Benjamin J.
AU - Markowitz, Steven
AU - Udasin, Iris
AU - Harrison, Denise
AU - Baron, Sherry
AU - Landrigan, Philip J.
AU - Levin, Stephen M.
AU - Southwick, Steven
T1 - Enduring Mental Health Morbidity and Social Function Impairment in World Trade Center Rescue, Recovery, and Cleanup Workers: The Psychological Dimension of an Environmental Health Disaster.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/09//
VL - 116
IS - 9
M3 - Article
SP - 1248
EP - 1253
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: The World Trade Center (WTC) attacks exposed thousands of workers to hazardous environmental conditions and psychological trauma. In 2002, to assess the health of these workers, Congress directed the National Institute for Occupational Safety and Health to establish the WTC Medical Monitoring and Treatment Program. This program has established a large cohort of WTC rescue, recovery, and cleanup workers. We previously documented extensive pulmonary dysfunction in this cohort related to toxic environmental exposures. OBJECTIVES: Our objective in this study was to describe mental health outcomes, social function impairment, and psychiatric comorbidity in the WTC worker cohort, as well as perceived symptomatology in workers' children. METHODS: Ten to 61 months after the WTC attack, 10,132 WTC workers completed a self-administered mental health questionnaire. RESULTS: Of the workers who completed the questionnaire, 11.1% met criteria for probable posttraumatic stress disorder (PTSD), 8.8% met criteria for probable depression, 5.0% met criteria for probable panic disorder, and 62% met criteria for substantial stress reaction. PTSD prevalence was comparable to that seen in returning Afghanistan war veterans and was much higher than in the U.S. general population. Point prevalence declined from 13.5% to 9.7% over the 5 years of observation. Comorbidity was extensive and included extremely high risks for impairment of social function. PTSD was significantly associated with loss of family members and friends, disruption of family, work, and social life, and higher rates of behavioral symptoms in children of workers. CONCLUSIONS: Working in 9/11 recovery operations is associated with chronic impairment of mental health and social functioning. Psychological distress and psychopathology in WTC workers greatly exceed population norms. Surveillance and treatment programs continue to be needed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental toxicology -- Research
KW - September 11 Terrorist Attacks, 2001 -- Psychological aspects
KW - Post-traumatic stress disorder
KW - Comorbidity
KW - Mental health
KW - depression
KW - disaster workers
KW - functional impairment
KW - occupational health
KW - posttraumatic stress disorder
KW - stress
KW - world trade center
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 34380280; Stellman, Jeanne Mager 1,2; Smith, Rebecca P. 1; Katz, Craig L. 1; Sharma, Vansh 1; Email Address: vansh.sharma@mssm.edu; Charney, Dennis S. 1; Herbert, Robin 3; Moline, Jacqueline 3; Luft, Benjamin J. 4; Markowitz, Steven 5; Udasin, Iris 6; Harrison, Denise 7; Baron, Sherry 8; Landrigan, Philip J. 3; Levin, Stephen M.; Southwick, Steven 1,9; Affiliations: 1: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA; 2: Department of Environmental and Occupational Health, School of Public Health, SUNY-Downstate, Brooklyn, New York, USA; 3: Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA; 4: Department of Medicine, SUNY-Stony Brook, Stony Brook, New York, USA; 5: Queens College, City University of New York, Flushing, New York, USA; 6: University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA; 7: Bellevue Hospital Center/New York University School of Medicine, New York, New York, USA; 8: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control, Washington, DC, USA; 9: Department of Psychiatry, Yale Medical School, VA Connecticut Healthcare System, National Center for Post-traumatic Stress Disorder, West Haven, Connecticut, USA; Issue Info: Sep2008, Vol. 116 Issue 9, p1248; Thesaurus Term: Environmental toxicology -- Research; Subject Term: September 11 Terrorist Attacks, 2001 -- Psychological aspects; Subject Term: Post-traumatic stress disorder; Subject Term: Comorbidity; Subject Term: Mental health; Author-Supplied Keyword: depression; Author-Supplied Keyword: disaster workers; Author-Supplied Keyword: functional impairment; Author-Supplied Keyword: occupational health; Author-Supplied Keyword: posttraumatic stress disorder; Author-Supplied Keyword: stress; Author-Supplied Keyword: world trade center ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 6p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105553729
T1 - Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells.
AU - Pacurari M
AU - Yin XJ
AU - Zhao J
AU - Ding M
AU - Leonard SS
AU - Schwegler-Berry D
AU - Ducatman BS
AU - Sbarra D
AU - Hoover MD
AU - Castranova V
AU - Vallyathan V
Y1 - 2008/09//
N1 - Accession Number: 105553729. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: National Institute for Occupational Safety and Health. NLM UID: 0330411.
KW - Neoplasms, Mesothelial -- Metabolism
KW - Oxidative Stress
KW - Particulate Matter
KW - Phosphotransferases -- Metabolism
KW - Asbestos
KW - Dose-Response Relationship
KW - Funding Source
KW - Nanotechnology
KW - Reactive Oxygen Species
KW - Tissue Culture Techniques
KW - Human
SP - 1211
EP - 1217
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 116
IS - 9
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - BACKGROUND: Single-wall carbon nanotubes (SWCNTs), with their unique physicochemical and mechanical properties, have many potential new applications in medicine and industry. There has been great concern subsequent to preliminary investigations of the toxicity, biopersistence, pathogenicity, and ability of SWCNTs to translocate to subpleural areas. These results compel studies of potential interactions of SWCNTs with mesothelial cells. OBJECTIVE: Exposure to asbestos is the primary cause of malignant mesothelioma in 80--90% of individuals who develop the disease. Because the mesothelial cells are the primary target cells of asbestos-induced molecular changes mediated through an oxidant-linked mechanism, we used normal mesothelial and malignant mesothelial cells to investigate alterations in molecular signaling in response to a commercially manufactured SWCNT. METHODS: In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species (ROS) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 (PARP-1), stimulation of extracellular signal-regulated kinase (ERKs), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor [kappa]B (NF-[kappa]B), and protein serine-threonine kinase (Akt). RESULTS: Exposure to SWCNTs induced ROS generation, increased cell death, enhanced DNA damage and H2AX phosphorylation, and activated PARP, AP-1, NF-[kappa]B, p38, and Akt in a dose-dependent manner. These events recapitulate some of the key molecular events involved in mesothelioma development associated with asbestos exposure. CONCLUSIONS: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies.
SN - 0091-6765
AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
U2 - PMID: 18795165.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Agresti, Ciara
AU - Tu, Zhigang
AU - Ng, Charlene
AU - Yang, Yongsheng
AU - Liang, Jun F.
T1 - Specific interactions between diphenhydramine and α-helical poly(glutamic acid) – A new ion-pairing complex for taste masking and pH-controlled diphenhydramine release
JO - European Journal of Pharmaceutics & Biopharmaceutics
JF - European Journal of Pharmaceutics & Biopharmaceutics
Y1 - 2008/09//
VL - 70
IS - 1
M3 - Article
SP - 226
EP - 233
SN - 09396411
AB - Abstract: Formation of drug/excipient complex through ionic interactions has proven to be very effective for both controlled release and taste masking. Unfortunately, the ionic interactions between drugs and small molecule excipients are usually weak, and the stability of the formed complexes can be greatly influenced by solution ionic strength. In this study, we explored to formulate diphenhydramine (DPH), a very bitter tasting drug, using small molecular weight and carboxyl group containing polymers. Studies showed that DPH interacted with α-helical poly(glutamic acid) specifically to produce DPH/poly(glutamic acid) complexes, mostly spherical in shape with a diameter of around 1.0μm. Other drugs with similar chemical structures as DPH, such as phenylephrine and pseudoephedrine, could not form complexes with poly(glutamic acid) or other polymers under the same conditions. Although DPH in DPH/poly(glutamic acid) complexes existed amorphously, it showed increased stability.In vitro studies using electronic tongue demonstrated that poly(glutamic acid) might be as effective as sucralose for DPH bitter taste blocking. In addition, DPH/poly(glutamic acid) complexes were not stable in neutral or weak acidic (pH>5) environments and dissolved rapidly and completely. Therefore, DPH/poly(glutamic acid) complex may serve as a new formulation for taste masking and controlled DPH release in gastrointestinal tract. This is the first report that small molecule drugs can interact with peptides of specific secondary structures to form stable complexes. In addition to greatly expanded ion-pairing excipient pool, application of peptides in drug formulation may also solve the selectivity and stability problems faced by current small molecule excipients. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutics & Biopharmaceutics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLUTAMIC acid
KW - HYDROGEN-ion concentration
KW - CONTROLLED release preparations
KW - PEPTIDES
KW - Controlled release
KW - Formulation
KW - Nanoparticles
KW - Peptide
KW - pH-sensitivity
KW - Taste masking
N1 - Accession Number: 34089969; Agresti, Ciara 1 Tu, Zhigang 1 Ng, Charlene 2 Yang, Yongsheng 3 Liang, Jun F. 1; Email Address: jliang2@stevens.edu; Affiliation: 1: Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA 2: McNeil Consumer Healthcare, Morris Plains, NJ, USA 3: Office of Testing and Research, Food and Drug Administration, Silver Spring, MD, USA; Source Info: Sep2008, Vol. 70 Issue 1, p226; Subject Term: GLUTAMIC acid; Subject Term: HYDROGEN-ion concentration; Subject Term: CONTROLLED release preparations; Subject Term: PEPTIDES; Author-Supplied Keyword: Controlled release; Author-Supplied Keyword: Formulation; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: Peptide; Author-Supplied Keyword: pH-sensitivity; Author-Supplied Keyword: Taste masking; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ejpb.2008.04.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Han, Beom Seok
AU - Nam, Ki Taek
AU - Park, Kidae
AU - Choi, Mina
AU - Kim, Seung Hee
AU - Jeong, Jayoung
AU - Jang, Dong Deuk
T1 - Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague–Dawley rats
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2008/09//
VL - 46
IS - 9
M3 - Article
SP - 3172
EP - 3177
SN - 02786915
AB - Abstract: 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLLUTANTS
KW - FOOD contamination
KW - CARCINOGENICITY testing
KW - RATS as laboratory animals
KW - DRINKING water
KW - WATER consumption
KW - (3-monochloropropane-1,2-diol) ( 3-MCPD )
KW - (chronic progressive nephropathy). ( CPN )
KW - (joint expert committee on food additives) ( JECFA )
KW - (Korea Food and Drug Administration) ( KFDA )
KW - (maximum tolerated dose) ( MTD )
KW - (Organisation for Economic Co-operation and Development) ( OECD )
KW - (scientific committee on food) ( SCF )
KW - (Sprague–Dawley) ( SD )
KW - 3-Monochloropropane-1,2-diol
KW - Carcinogenicity
KW - Leydig cell tumor
KW - Renal tubule carcinoma
KW - SD rats
N1 - Accession Number: 34092606; Cho, Wan-Seob 1 Han, Beom Seok 1 Nam, Ki Taek 1 Park, Kidae 1 Choi, Mina 1 Kim, Seung Hee 1 Jeong, Jayoung 1 Jang, Dong Deuk; Email Address: chows77@kfda.go.kr; Affiliation: 1: Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea; Source Info: Sep2008, Vol. 46 Issue 9, p3172; Subject Term: POLLUTANTS; Subject Term: FOOD contamination; Subject Term: CARCINOGENICITY testing; Subject Term: RATS as laboratory animals; Subject Term: DRINKING water; Subject Term: WATER consumption; Author-Supplied Keyword: (3-monochloropropane-1,2-diol) ( 3-MCPD ); Author-Supplied Keyword: (chronic progressive nephropathy). ( CPN ); Author-Supplied Keyword: (joint expert committee on food additives) ( JECFA ); Author-Supplied Keyword: (Korea Food and Drug Administration) ( KFDA ); Author-Supplied Keyword: (maximum tolerated dose) ( MTD ); Author-Supplied Keyword: (Organisation for Economic Co-operation and Development) ( OECD ); Author-Supplied Keyword: (scientific committee on food) ( SCF ); Author-Supplied Keyword: (Sprague–Dawley) ( SD ); Author-Supplied Keyword: 3-Monochloropropane-1,2-diol; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Leydig cell tumor; Author-Supplied Keyword: Renal tubule carcinoma; Author-Supplied Keyword: SD rats; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.fct.2008.07.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miliotis, M.
AU - Dennis, S.
AU - Buchanan, R.
AU - Potter, M.
T1 - Role of epidemiology in microbial risk assessment.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/09//
VL - 25
IS - 9
M3 - Article
SP - 1052
EP - 1057
PB - Taylor & Francis Ltd
SN - 19440049
AB - Microbial risk assessment (MRA) is a systematic tool to evaluate the likelihood of exposure to food-borne pathogens and the resulting impact of exposure on consumer health. In addition, MRA can be used to evaluate the public health impact of intervention or control measures designed to prevent or reduce pathogens at any or all of the steps in our complex food production system. Epidemiological studies provide useful information and data for MRA. This paper discusses the use and limitations of epidemiological data in the development and validation of MRA using examples from published microbial risk assessments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Pathogenic microorganisms
KW - Epidemiology -- Research
KW - HEALTH
KW - Microbial contamination
KW - Microorganisms -- Evaluation
KW - Epidemiology -- Statistical methods
KW - Consumers
KW - Public health administration
KW - Public health -- Social aspects
KW - epidemiology
KW - exposure assessment
KW - hazard characterization
KW - hazard identification
KW - microbial risk assessment
KW - risk characterization
N1 - Accession Number: 34294109; Miliotis, M. 1; Email Address: marianna.miliotis@fda.hhs.gov; Dennis, S. 1; Buchanan, R. 1; Potter, M. 1; Affiliations: 1: US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA; Issue Info: Sep2008, Vol. 25 Issue 9, p1052; Thesaurus Term: Risk assessment; Thesaurus Term: Pathogenic microorganisms; Thesaurus Term: Epidemiology -- Research; Thesaurus Term: HEALTH; Thesaurus Term: Microbial contamination; Subject Term: Microorganisms -- Evaluation; Subject Term: Epidemiology -- Statistical methods; Subject Term: Consumers; Subject Term: Public health administration; Subject Term: Public health -- Social aspects; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: hazard characterization; Author-Supplied Keyword: hazard identification; Author-Supplied Keyword: microbial risk assessment; Author-Supplied Keyword: risk characterization; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 6p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/02652030802056618
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34294109&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jia, Yiping
AU - Alayash, Abdu I.
T1 - Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2008/09//
VL - 45
IS - 5
M3 - Article
SP - 659
EP - 666
SN - 08915849
AB - Abstract: The toxicity of acellular hemoglobin (Hb)–based therapeutics has been attributed in part to the uncontrolled oxidative reactions. A variety of antioxidant strategies to ameliorate potential oxidative damage in vivo have been suggested. We have examined the effects of (-)-epigallocatechin gallate (EGCG), a green tea polyphenol compound widely regarded as a chain-breaking antioxidant, on the oxidative stability of diaspirin crosslinked Hb (DBBF) and its cytotoxic ferryl intermediate. DBBF (ferrous) was rapidly oxidized to the ferric form in the presence of EGCG relative to the normal spontaneous oxidation of this Hb. The fast elimination of ferrous Hb is probably due to the ability of EGCG to produce hydrogen peroxide (H2O2) as these reactions were almost completely reversed by the addition of catalase and superoxide dismutase to the reaction medium. EGCG, however, effectively reduced ferryl back to ferric Hb in a biphasic kinetic reaction at physiological pH. At acidic pH where the autoreduction of protonated ferryl Hb is enhanced, a monophasic reduction process of the ferryl heme is achieved. A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROGEN-ion concentration
KW - HEMOGLOBIN polymorphisms
KW - DISINFECTION & disinfectants
KW - HEMOGLOBIN
KW - (-)-Epigallocatechin gallate
KW - (-)-epigallocatechin gallate ( EGCG )
KW - 5-dibromosalicyl)fumarate. ( DBBF )
KW - Blood substitutes
KW - Hemoglobin
KW - hemoglobin ( Hb )
KW - hemoglobin-based oxygen carrier ( HBOC )
KW - Human hemoglobin cross-linked with bis(3
KW - Human hemoglobin cross-linked with bis(3,5-dibromosalicyl)fumarate. ( DBBF )
KW - hydrogen peroxide ( H2O2 )
KW - myoglobin ( Mb )
N1 - Accession Number: 33630647; Jia, Yiping; Email Address: yiping.jia@fda.hhs.gov Alayash, Abdu I. 1; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), National Institutes of Health (NIH) Campus, 8800 Rockville Pike, Bldg. 29, Rm. 129, Bethesda, MD 20892, USA; Source Info: Sep2008, Vol. 45 Issue 5, p659; Subject Term: HYDROGEN-ion concentration; Subject Term: HEMOGLOBIN polymorphisms; Subject Term: DISINFECTION & disinfectants; Subject Term: HEMOGLOBIN; Author-Supplied Keyword: (-)-Epigallocatechin gallate; Author-Supplied Keyword: (-)-epigallocatechin gallate ( EGCG ); Author-Supplied Keyword: 5-dibromosalicyl)fumarate. ( DBBF ); Author-Supplied Keyword: Blood substitutes; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: hemoglobin ( Hb ); Author-Supplied Keyword: hemoglobin-based oxygen carrier ( HBOC ); Author-Supplied Keyword: Human hemoglobin cross-linked with bis(3; Author-Supplied Keyword: Human hemoglobin cross-linked with bis(3,5-dibromosalicyl)fumarate. ( DBBF ); Author-Supplied Keyword: hydrogen peroxide ( H2O2 ); Author-Supplied Keyword: myoglobin ( Mb ); NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2008.05.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Hin C.
AU - Kioi, Mitomu
AU - Han, Jing
AU - Puri, Raj K.
AU - Goodman, Jesse L.
T1 - Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells
JO - Genomics
JF - Genomics
Y1 - 2008/09//
VL - 92
IS - 3
M3 - Article
SP - 144
EP - 151
SN - 08887543
AB - Abstract: Anaplasma phagocytophilum (Ap), the etiologic agent of the tick-borne disease human granulocytic anaplasmosis, is an obligate intracellular pathogen unique in its ability to target and replicate within neutrophils. We define and compare the spectra of host gene expression in response to Ap infection of human neutrophils and of HL-60 cells using long (70-mer)-oligonucleotide array technology. In addition to apoptosis-related genes, genes involved in signaling pathways, transcriptional regulation, immune response, host defense, cell adhesion, and cytoskeleton were modulated in neutrophils infected with Ap. Ap infection affected the same pathways in HL-60 cells but transcriptional changes occurred more slowly and in a reduced spectrum of genes. Gene expression changes detected by microarray were confirmed for randomly selected genes by QRT-PCR and Western blot studies. These studies demonstrate for the first time that the ERK pathway is activated in Ap-infected neutrophils and also define multiple pathways that are activated during intracellular Ap infection, which together serve to prolong the cell survival that is needed to allow bacterial replication and survival in neutrophils, which otherwise would rapidly apoptose. [Copyright &y& Elsevier]
AB - Copyright of Genomics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - ANAPLASMOSIS
KW - APOPTOSIS
KW - NEUTROPHILS -- Immunology
KW - PATHOGENIC microorganisms
KW - GENETIC engineering
KW - GENETIC aspects
KW - Anaplasma phagocytophilum
KW - Apoptosis
KW - Gene expression
KW - HL-60 cells
KW - Human granulocytic anaplasmosis
KW - Neutrophils
N1 - Accession Number: 34001970; Lee, Hin C. 1 Kioi, Mitomu 1 Han, Jing 1 Puri, Raj K. 1 Goodman, Jesse L. 2; Email Address: jesse.goodman@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Office of the Center Director, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Sep2008, Vol. 92 Issue 3, p144; Subject Term: GENE expression; Subject Term: ANAPLASMOSIS; Subject Term: APOPTOSIS; Subject Term: NEUTROPHILS -- Immunology; Subject Term: PATHOGENIC microorganisms; Subject Term: GENETIC engineering; Subject Term: GENETIC aspects; Author-Supplied Keyword: Anaplasma phagocytophilum; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: HL-60 cells; Author-Supplied Keyword: Human granulocytic anaplasmosis; Author-Supplied Keyword: Neutrophils; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ygeno.2008.05.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105966270
T1 - The distribution of public spending for health care in the United States, 2002.
AU - Selden TM
AU - Sing M
Y1 - 2008/09//Sep/Oct2008
N1 - Accession Number: 105966270. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Demography -- United States
KW - Financing, Government -- Trends
KW - Health Care Industry -- Economics
KW - Age Factors
KW - Aged
KW - Child
KW - Chronic Disease
KW - Descriptive Research
KW - Disabled
KW - Health Status
KW - Incidence
KW - Income
KW - Insurance, Health
KW - Medicaid
KW - Medicare
KW - Models, Statistical
KW - Panel Studies -- United States
KW - Race Factors
KW - Secondary Analysis
KW - Sex Factors
KW - Taxes
KW - Uncompensated Care
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - United States Centers for Medicare and Medicaid Services
KW - Human
SP - w349
EP - 59
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 5
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - U.S. health care spending is projected to approach $2.4 trillion in 2008; a large share will be paid by government outlays and tax subsidies. Other countries routinely conduct incidence analyses of public health care spending, yet we know of no recent and comprehensive incidence studies for the United States. We examined data for 2002 from the Medical Expenditure Panel Survey aligned to the National Health Expenditure Accounts and augmented with simulated tax subsidies. The public sector accounted for 56.1 percent of health spending within the civilian noninstitutionalized population. Our analysis highlights this sector's role in financing the care of seniors and people in poor health.
SN - 0278-2715
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), in Rockville, Maryland, USA. tselden@ahrq.gov
U2 - PMID: 18664527.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105966270&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105966266
T1 - Health information technology: strategic initiatives, real progress.
AU - Kolodner RM
AU - Cohn SP
AU - Friedman CP
Y1 - 2008/09//Sep/Oct2008
N1 - Accession Number: 105966266. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Diamond CC, Shirky C. Health information technology: a few years of magical thinking? (HEALTH AFF) Sep/Oct2008; 27 (5): w383-90. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Informatics. NLM UID: 8303128.
KW - Health Care Reform
KW - Health Information -- Standards
KW - Information Technology -- Standards
KW - Data Security
KW - Health Information Networks
KW - Health Policy
KW - Privacy and Confidentiality
KW - Quality Improvement
KW - Shared Governance
KW - Strategic Planning
SP - w391
EP - 5
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 5
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - We fully agree with Carol Diamond and Clay Shirky that deployment of health information technology (IT) is necessary but not sufficient for transforming U.S. health care. However, the recent work to advance health IT is far from an exercise in 'magical thinking.' It has been strategic thinking. To illustrate this, we highlight recent initiatives and progress under four focus areas: adoption, governance, privacy and security, and interoperability. In addition, solutions exist for health IT to advance rapidly without adversely affecting future policy choices. A broad national consensus is emerging in support of advancing health IT to enable the transformation of health and care.
SN - 0278-2715
AD - Health Information Technology, Washington, DC, USA. robert.kolodner@hhs.gov
U2 - PMID: 18713825.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105966266&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dhippayom, Teerapon
AU - Walker, Roger
T1 - Impact of the reduction of the prescription charge in Wales on the prescribing of non-sedating antihistamines in primary care
JO - Health Policy
JF - Health Policy
Y1 - 2008/09//
VL - 87
IS - 3
M3 - Article
SP - 309
EP - 315
SN - 01688510
AB - Abstract: Objective: Determine the impact of the phased reduction of the prescription charge in Wales on prescriptions for non-sedating antihistamines. Method: Prescription items for non-sedating antihistamines dispensed in 22 Local Health Boards (LHBs) in Wales and 15 Primary Care Trusts in the South East of England were analysed between October 2001 and September 2006. Results: There was an increase in percent change (median (interquartile range [IQR])) in prescription items for non-sedating antihistamines dispensed in Wales in the 24 months after the first reduction of the prescription charge in October 2004 compared to the 24 months prior to this (13.7 [10.9–17.1] vs. 7.3 [5.0–10.7], p <0.001). In the South East of England there was no change over the same periods (4.4 [3.4–7.5] vs. 4.5 [0.8–7.9], p =0.73). In the five least deprived LHBs the percent change in prescriptions for non-sedating antihistamines increased in the 24 months after the reduction of the prescription charge compared to the previous 24 months (14.3 [11.5–19.4] vs. 9.0 [9.1–13.5], p =0.04). In contrast there was no change over the two periods in the five most deprived LHBs (13.1 [10.9–17.5] vs. 9.5 [2.9–10.4], p =0.08]. Conclusions: The phased reduction of the prescription charge in Wales coincided with an increase in the number of non-sedating antihistamines dispensed in Wales. This was only evident in the least deprived LHBs. [Copyright &y& Elsevier]
AB - Copyright of Health Policy is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRESCRIPTION pricing
KW - COPAYMENTS (Insurance)
KW - COST shifting
KW - MEDICAL economics
KW - ANTIHISTAMINES
KW - PRIMARY care (Medicine)
KW - MEDICAL policy
KW - WALES
KW - Co-payment
KW - Cost sharing
KW - Non-sedating antihistamines
KW - Prescribing pattern
KW - Prescription charge
N1 - Accession Number: 33526853; Dhippayom, Teerapon 1; Walker, Roger 1,2; Email Address: roger.walker@nphs.wales.nhs.uk; Affiliations: 1: Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom; 2: Consultant in Pharmaceutical Public Health, National Public Health Service for Wales, Temple of Peace & Health, Cardiff CF10 3NW, United Kingdom; Issue Info: Sep2008, Vol. 87 Issue 3, p309; Thesaurus Term: PRESCRIPTION pricing; Thesaurus Term: COPAYMENTS (Insurance); Thesaurus Term: COST shifting; Thesaurus Term: MEDICAL economics; Subject Term: ANTIHISTAMINES; Subject Term: PRIMARY care (Medicine); Subject Term: MEDICAL policy; Subject: WALES; Author-Supplied Keyword: Co-payment; Author-Supplied Keyword: Cost sharing; Author-Supplied Keyword: Non-sedating antihistamines; Author-Supplied Keyword: Prescribing pattern; Author-Supplied Keyword: Prescription charge; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.healthpol.2008.01.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=33526853&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Mutter, Ryan L.
AU - Wong, Herbert S.
AU - Goldfarb, Marsha G.
T1 - The Effects of Hospital Competition on Inpatient Quality of Care.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2008///Fall2008
VL - 45
IS - 3
M3 - Article
SP - 263
EP - 279
SN - 00469580
AB - Existing empirical studies have produced inconclusive, and sometimes contradictory, findings on the effects of hospital competition on inpatient quality of care. These inconsistencies may be due to the use of different methodologies, hospital competition measures, and hospital quality measures. This paper applies the Quality Indicator software from the Agency for Healthcare Research and Quality to the 1997 Healthcare Cost and Utilization Project State Inpatient Databases to create three versions (i.e., observed, risk-adjusted, and "smoothed") of 38 distinct measures of inpatient quality. The relationship between 12 different hospital competition measures and these quality measures are assessed, using ordinary least squares, two-step efficient generalized method of moments, and negative binomial regression techniques. We find that across estimation strategies, hospital competition has an impact on a number of hospital quality measures. However, the effect is not unidirectional: some indicators show improvements in hospital quality with greater levels of competition, some show decreases in hospital quality, and others are unaffected. We provide hypotheses based on emerging areas of research that could explain these findings, but inconsistencies remain. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - ESTIMATION theory
KW - HOSPITALS
KW - DATABASES
KW - INPATIENT care
KW - CARING
KW - COMPETITION
KW - REGRESSION (Psychology)
KW - MEDICAL care costs
N1 - Accession Number: 35285137; Mutter, Ryan L. 1; Email Address: Ryan.Mutter@ahrq.hhs.gov; Wong, Herbert S. 1; Goldfarb, Marsha G. 2; Affiliations: 1: Economists, Center for Delivery, Organization and Markets (CDOM), Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Rockville, MD 20850; 2: Professor, Department of Economics at the University of Maryland, Baltimore County; Issue Info: Fall2008, Vol. 45 Issue 3, p263; Thesaurus Term: MEDICAL care; Thesaurus Term: ESTIMATION theory; Thesaurus Term: HOSPITALS; Thesaurus Term: DATABASES; Subject Term: INPATIENT care; Subject Term: CARING; Subject Term: COMPETITION; Subject Term: REGRESSION (Psychology); Subject Term: MEDICAL care costs; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 17p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Gutiérrez, Ángel J.
AU - González-Weller, Dailos
AU - González, Tomás
AU - Burgos, Antonio
AU - Lozano, Gonzalo
AU - Hardisson, Arturo
T1 - Content of trace metals (iron, zinc, manganese, chromium, copper, nickel) in canned variegated scallops (Chlamys varia).
JO - International Journal of Food Sciences & Nutrition
JF - International Journal of Food Sciences & Nutrition
Y1 - 2008/09//
VL - 59
IS - 6
M3 - Article
SP - 535
EP - 543
PB - Taylor & Francis Ltd
SN - 09637486
AB - This article presents the results obtained through a study of the concentration of trace metals (iron, zinc, manganese, chromium, copper, nickel) in some conserves of variegated scallops (Chlamys varia, Bivalvia, Mollusca). A total of 300 samples of seven different commercial brands (named A, B, D, H, J, L and M) and one processing type, 'scallop sauce', were analysed. Samples were collected weekly in a large shopping centre in Santa Cruz de Tenerife during a 12-month period. Variegated scallops have considerable concentrations of zinc, cupper and manganese, so that their dietary intake constitutes an important source of these metals. However, they have low concentrations of chrome and nickel, and the levels of iron are similar to those found in other bivalve molluscs. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Food Sciences & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCALLOPS
KW - TRACE metal
KW - CANNED foods
KW - FOOD adulteration & inspection
KW - ATOMIC emission spectroscopy
KW - TRACE elements -- Analysis
KW - food
KW - inductively coupled plasma-atomic emission spectrometry
KW - Metals
KW - variegated scallops
N1 - Accession Number: 33522668; Gutiérrez, Ángel J. 1 González-Weller, Dailos 2; Email Address: dgonzal@ull.es González, Tomás 3 Burgos, Antonio 4 Lozano, Gonzalo 5 Hardisson, Arturo 2; Affiliation: 1: Department of Toxicology and Animal Biology (Marine Sciences), University of La Laguna, 2: Department of Toxicology, University of La Laguna, 3: Canarian Public Health Service, Santa Cruz de Tenerife, 4: Department of Preventive Medicine and Public Health, University of La Laguna, 5: Department of Animal Biology (Marine Sciences), University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain; Source Info: Sep2008, Vol. 59 Issue 6, p535; Subject Term: SCALLOPS; Subject Term: TRACE metal; Subject Term: CANNED foods; Subject Term: FOOD adulteration & inspection; Subject Term: ATOMIC emission spectroscopy; Subject Term: TRACE elements -- Analysis; Author-Supplied Keyword: food; Author-Supplied Keyword: inductively coupled plasma-atomic emission spectrometry; Author-Supplied Keyword: Metals; Author-Supplied Keyword: variegated scallops; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311422 Specialty Canning; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 9p; Illustrations: 4 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/09637480701567899
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105548073
T1 - The effect of tax subsidies on high health care expenditure burdens in the United States.
AU - Selden TM
Y1 - 2008/09//
N1 - Accession Number: 105548073. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 101132988.
KW - Health Care Costs -- Statistics and Numerical Data
KW - Insurance, Health -- Economics
KW - Public Assistance -- Economics
KW - Taxes -- Economics
KW - Economic Aspects of Illness
KW - Economics -- Statistics and Numerical Data
KW - Insurance Benefits -- Economics
KW - Medically Uninsured -- Statistics and Numerical Data
KW - Models, Statistical
KW - Poverty
KW - Public Assistance -- Statistics and Numerical Data
KW - United States
SP - 209
EP - 223
JO - International Journal of Health Care Finance & Economics
JF - International Journal of Health Care Finance & Economics
JA - INT J HEALTH CARE FINANC ECON
VL - 8
IS - 3
CY - ,
PB - Springer Science & Business Media B.V.
SN - 1389-6563
AD - Division of Modeling and Simulation, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, 20850, USA, tselden@ahrq.gov.
U2 - PMID: 18587643.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Selden, Thomas M.
AD - Agency for Healthcare Research and Quality, Rockville, MD
T1 - The Effect of Tax Subsidies on High Health Care Expenditure Burdens in the United States
JO - International Journal of Health Care Finance and Economics
JF - International Journal of Health Care Finance and Economics
Y1 - 2008/09//
VL - 8
IS - 3
SP - 209
EP - 223
SN - 13896563
N1 - Accession Number: 0995696; Keywords: Expenditure; Health; Health Care; Subsidies; Tax; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200810
N2 - Previous analyses of families with high health care expenditure burdens have ignored the potentially mitigating effects of tax subsidies. This analysis uses data from the Medical Expenditure Panel Survey (MEPS) to fill this gap. A range of health expenditure burden measures are computed, with and without tax subsidies, showing the impact that tax subsidies have on both the prevalence and magnitude of high health care spending burdens among the nonelderly.
KW - Consumer Economics: Empirical Analysis D12
KW - Personal Income and Other Nonbusiness Taxes and Subsidies; includes inheritance and gift taxes H24
KW - Analysis of Health Care Markets I11
KW - Health: Government Policy; Regulation; Public Health I18
L3 - http://link.springer.com/journal/volumesAndIssues/10754
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UR - http://dx.doi.org/10.1007/s10754-008-9043-1
UR - http://link.springer.com/journal/volumesAndIssues/10754
DP - EBSCOhost
DB - ecn
ER -
TY - NEWS
AU - Rakheja, Subhash
AU - Dong, R.G.
T1 - Workplace vibration exposure: Characterization, assessment and ergonomic interventions
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/09//
VL - 38
IS - 9/10
M3 - Editorial
SP - 651
EP - 651
SN - 01698141
N1 - Accession Number: 34199328; Rakheja, Subhash 1; Email Address: guf2@cdc.gov; Dong, R.G. 2; Affiliations: 1: CONCAVE Research Centre, Concordia University, Montreal, Canada; 2: Engineering Control and Technology Branch, National Institute of Occupational Safety and Health, Morgantown, WV, USA; Issue Info: Sep2008, Vol. 38 Issue 9/10, p651; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.ergon.2008.02.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34199328&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Maeda, Setsuo
AU - Shibata, Nobuyuki
T1 - Temporary threshold shifts (TTS) of fingertip vibrotactile perception thresholds from hand-held tool vibration exposures at working surface
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/09//
VL - 38
IS - 9/10
M3 - Article
SP - 693
EP - 696
SN - 01698141
AB - Abstract: Objective: The effect of hand-held vibration exposure in the working surface on the temporary threshold shift (TTS) in vibrotactile perception threshold at the fingers has been studied. Method: Subjects were exposed to the hand-held tool with the exposure time of 5min at different positions in the working surface. A controlled condition with no vibration was included. In order to obtain the TTS in the fingertip vibrotactile perception threshold, the vibrotactile perception thresholds were measured before and after the subjects were exposed to hand-transmitted vibration from the hand-held tool. Results: The results of TTS were different at different positions in the working surface, even though the hand-held tool vibration magnitudes were the same frequency-weighted rms acceleration according to the ISO 5349-1 standard. Conclusions: Even though the tool vibration magnitudes were the same, the TTS values were different in the working surface. The results suggest that the ISO 5349-1 standard needs to be revised to include other factors that many influence the risk of obtaining a vibration-induced injury, such as posture. Relevance to industry: Results from this study demonstrated the problem of the frequency-weighting method of the ISO 5349-1 standard in the working surface. Therefore, in the assembly lines or worktables of the industries, even though the tool position is in the working surface, the employees or employers must consider about the position of the tools to reduce the effect of vibration exposure for preventing the vibration injuries. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Threshold (Perception)
KW - Machine-tools -- Vibration
KW - Industrial workers
KW - Vibration (Mechanics) -- Physiological effect
KW - Work environment
KW - Frequencies of oscillating systems
KW - Frequency-weighting method
KW - Hand-arm vibration
KW - ISO standard
KW - TTS
KW - Working surface
N1 - Accession Number: 34199333; Maeda, Setsuo; Email Address: maedas@h.jnisoh.go.jp; Shibata, Nobuyuki 1; Affiliations: 1: Measurement and Control of Work Environment Research Group, Japan National Institute of Occupational Safety and Health (JNIOSH), Nagao 6-21-1, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: Sep2008, Vol. 38 Issue 9/10, p693; Thesaurus Term: Industrial safety; Subject Term: Threshold (Perception); Subject Term: Machine-tools -- Vibration; Subject Term: Industrial workers; Subject Term: Vibration (Mechanics) -- Physiological effect; Subject Term: Work environment; Subject Term: Frequencies of oscillating systems; Author-Supplied Keyword: Frequency-weighting method; Author-Supplied Keyword: Hand-arm vibration; Author-Supplied Keyword: ISO standard; Author-Supplied Keyword: TTS; Author-Supplied Keyword: Working surface; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ergon.2007.10.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shibata, Nobuyuki
AU - Maeda, Setsuo
T1 - Effect of tool handle diameter on temporary threshold shift (TTS) of vibrotactile perception
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/09//
VL - 38
IS - 9/10
M3 - Article
SP - 697
EP - 702
SN - 01698141
AB - Abstract: Objective: Temporary threshold shifts (TTSs) of fingertip vibrotactile perception were measured in a laboratory study to examine the effects of handle size in combination with vibration frequency, amplitude, and frequency weighting, on human responses to hand–arm vibration (HAV). Methods: Ten healthy male subjects were exposed to two levels of HAV: 125Hz–5.0m/s2 and 125Hz–20.0m/s2 (represented as a combination of vibration frequency and rms acceleration) using two different handles (22 and 35mm in diameter) excited with a shaker. A simplified version of method of limits were used to measure vibrotactile perception thresholds and TTSs were then calculated as the difference between fingertip vibrotactile perception thresholds measured before and after 5min vibration exposure. Results: At 125Hz–5.0m/s2 vibration, the handle size significantly affected TTSs in fingertip vibrotactile perception. In contrast, the handle size did not significantly affect the TTSs at 125Hz–2.0m/s2 vibration. Conclusions: Our results suggest that handle size is more sensitive to the TTS in fingertip vibrotactile perception under relatively lower vibration level. From a viewpoint of risk assessment to HAV exposure, TTS after short-term exposure to HAV is indicative of HAV syndrome resulted from long-term exposure to HAV. Since the long-term effect has been the accumulation of repeated short-term effect of HAV, our results suggest that the tool handle size is recommended to be designed based on the vibration level so as to diminish TTS. Relevance to industry: Results obtained from this study show that the range of handle diameter examined in this study does not have a significant influence on TTS in vibrotactile perception. This finding gives fundamental data to the designing of hand-held power tools. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk assessment
KW - Threshold (Perception)
KW - Handles
KW - Machine-tools -- Vibration
KW - Vibration syndrome
KW - Power tools
KW - Frequencies of oscillating systems
KW - Work environment
KW - Hand–arm vibration
KW - Handle size
KW - Temporary threshold shift (TTS)
KW - Vibrotactile perception threshold
N1 - Accession Number: 34199334; Shibata, Nobuyuki 1; Maeda, Setsuo; Email Address: maedas@h.jniosh.go.jp; Affiliations: 1: Measurement and Control of Work Environment Research Group, National Institute of Occupational Safety and Health, Japan, 6-21-1, Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: Sep2008, Vol. 38 Issue 9/10, p697; Thesaurus Term: Risk assessment; Subject Term: Threshold (Perception); Subject Term: Handles; Subject Term: Machine-tools -- Vibration; Subject Term: Vibration syndrome; Subject Term: Power tools; Subject Term: Frequencies of oscillating systems; Subject Term: Work environment; Author-Supplied Keyword: Hand–arm vibration; Author-Supplied Keyword: Handle size; Author-Supplied Keyword: Temporary threshold shift (TTS); Author-Supplied Keyword: Vibrotactile perception threshold; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ergon.2007.10.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34199334&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Page, Steven J.
AU - Reed, Randy
AU - Listak, Jeffrey M.
T1 - An expanded model for predicting surface coal mine drill respirable dust emissions.
JO - International Journal of Mining, Reclamation & Environment
JF - International Journal of Mining, Reclamation & Environment
Y1 - 2008/09//
VL - 22
IS - 3
M3 - Article
SP - 210
EP - 221
SN - 17480930
AB - Overexposure to airborne respirable crystalline silica dust can cause disabling or fatal respiratory disease, and mine worker exposure to silica dust continues to be an ongoing occupational health concern. Exposures of surface coal mine rock drillers to respirable crystalline silica are of particular concern. On surface coal mine drills, bailing air flushes the cuttings out of the drill hole. Conveyor belting material is typically used to fabricate a shroud around the drill deck in an effort to contain the drill dust so that it can be captured by a collector. Dust leakage from the drill shroud is usually the worst dust source problem on most drills. The focus of this work is drill shroud dust leakage and the relationships of various drill parameters on this leakage. Experimental data were obtained and used in combination with dimensional analysis to establish these relationships. In general, it is found that airborne respirable dust (ARD) concentrations vary in a direct relationship with shroud leakage area and in an inverse relationship with drill deck cross-sectional area and shroud height. This work expands the testing and dimensional analysis previously reported for collector/bailing air flow ratios ranging from 2:1 to 4:1 to include ratios approaching 1:1. A semi-empirical mathematical model has been developed and expanded to describe ARD generation on surface coal mine drills. Geometric parameters included are drill deck height and cross-sectional area, shroud leakage associated with the deck shroud, and the operational parameters of bailing airflow and dust collector airflow. The relationships can be described by logarithmic functions and yield predictive ARD values, which fall in the range measured on operating drills for collector/bailing air flow ratios greater than 2. However, at values of collector/bailing air flow ratios of approximately 1.1, the amount of ARD shows minimal response, if any, to drill deck shroud improvements that do not result in near-perfect seals. This is a condition that can occur in actual operation and is a substantially different result than previously expected and reported. Application of these results should provide mine operators with sufficient information to determine (1) the relative magnitude of their dust emissions, (2) where they should focus their efforts to reduce ARD emissions and (3) the improvement they could reasonably expect to achieve. Given that exposures of surface coal mine rock drillers to respirable crystalline silica are of particular concern, substantial reductions of airborne silica dust during drilling may be estimated and achieved through use of the analysis presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Mining, Reclamation & Environment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - MINES & mineral resources
KW - DUST
KW - EMISSIONS (Air pollution)
KW - CONVEYOR belts
KW - INDUSTRIAL hygiene
KW - COAL industry
KW - AIR pollution
KW - MATHEMATICAL models
KW - dimensional analysis
KW - drill
KW - dust
KW - model
N1 - Accession Number: 34576572; Page, Steven J. 1; Email Address: sep8@cdc.gov Reed, Randy 1 Listak, Jeffrey M. 1; Affiliation: 1: Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, USA; Source Info: Sep2008, Vol. 22 Issue 3, p210; Subject Term: COAL mines & mining; Subject Term: MINES & mineral resources; Subject Term: DUST; Subject Term: EMISSIONS (Air pollution); Subject Term: CONVEYOR belts; Subject Term: INDUSTRIAL hygiene; Subject Term: COAL industry; Subject Term: AIR pollution; Subject Term: MATHEMATICAL models; Author-Supplied Keyword: dimensional analysis; Author-Supplied Keyword: drill; Author-Supplied Keyword: dust; Author-Supplied Keyword: model; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 326220 Rubber and Plastics Hoses and Belting Manufacturing; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 12p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/17480930701828833
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Syamlal, Girija
AU - Mazurek, Jacek M.
T1 - Prevalence of Asthma Among Youth on Hispanic-Operated Farms in the United States--2000.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2008/09//
VL - 13
IS - 3
M3 - Article
SP - 155
EP - 164
SN - 1059924X
AB - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p < .05) and serious asthma attacks (1.6% versus 1.3%; p> .05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p < .05) and among youth living on livestock farms than among youth on crop farms (9.4% versus 7.4%; p < .05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASE prevalence
KW - OCCUPATIONAL diseases
KW - ASTHMA
KW - AGE factors in disease
KW - GENDER
KW - YOUNG workers
KW - FARMERS
KW - FARMS
KW - UNITED States
KW - Agricultural workers
KW - asthma
KW - Hispanics
KW - youth
N1 - Accession Number: 36001135; Syamlal, Girija 1; Email Address: gos2@cdc.gov Mazurek, Jacek M. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morganton, West Virginia, USA; Source Info: 2008, Vol. 13 Issue 3, p155; Subject Term: DISEASE prevalence; Subject Term: OCCUPATIONAL diseases; Subject Term: ASTHMA; Subject Term: AGE factors in disease; Subject Term: GENDER; Subject Term: YOUNG workers; Subject Term: FARMERS; Subject Term: FARMS; Subject Term: UNITED States; Author-Supplied Keyword: Agricultural workers; Author-Supplied Keyword: asthma; Author-Supplied Keyword: Hispanics; Author-Supplied Keyword: youth; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/10599240802397875
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36001135&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105593786
T1 - Prevalence of asthma among youth on Hispanic-operated farms in the United States -- 2000.
AU - Syamlal G
AU - Mazurek JM
Y1 - 2008/09//
N1 - Accession Number: 105593786. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9421530.
KW - Agriculture
KW - Asthma -- Epidemiology
KW - Environmental Exposure -- Adverse Effects
KW - Hispanics -- Statistics and Numerical Data
KW - Occupational Diseases -- Epidemiology
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Asthma -- Ethnology
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Motor Vehicles
KW - Occupational Diseases -- Ethnology
KW - Occupational Exposure
KW - Occupational Health
KW - Prevalence
KW - Risk Factors
KW - Sex Factors
KW - United States
KW - Human
SP - 155
EP - 164
JO - Journal of Agromedicine
JF - Journal of Agromedicine
JA - J AGROMED
VL - 13
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p < .05) and serious asthma attacks (1.6% versus 1.3%; p > .05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p < .05) and among youth living on livestock farms than among youth on crop farms (9.4% versus 7.4%; p < .05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations.
SN - 1059-924X
AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop HG900.2, Morgantown, WV 26505, USA; gos2@cdc.gov
U2 - PMID: 19064420.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chen, James J.
AU - Lin, Karl K.
AU - Tsong, Yi
T1 - Special Issue on Non-Clinical Statistics Guest Editors' Notes.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 805
EP - 807
PB - Taylor & Francis Ltd
SN - 10543406
AB - The article discusses various reports within the issue, including the articles on the development of pharmacogenomic classifiers, like feature extraction and feature selection, and class prediction and another about a novel strategy for selecting important genes.
KW - PHARMACOGENOMICS
KW - GENES
N1 - Accession Number: 34212766; Chen, James J. 1 Lin, Karl K. 2 Tsong, Yi 2; Affiliation: 1: Division of Personalized Nutrition and Medicine, National Center of Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA 2: Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p805; Subject Term: PHARMACOGENOMICS; Subject Term: GENES; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/10543400802334164
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dung-Tsa Chen
AU - Schell, Michael J.
AU - Chen, James J.
AU - Fulp, William J.
AU - Eschrich, Steven
AU - Yeatman, Timothy
T1 - A Predictive Risk Probability Approach for Microarray Data with Survival as an Endpoint.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 841
EP - 852
PB - Taylor & Francis Ltd
SN - 10543406
AB - Gene expression profiling has played an important role in cancer risk classification and has shown promising results. Since gene expression profiling often involves determination of a set of top rank genes for analysis, it is important to evaluate how modeling performance varies with the number of selected top ranked genes incorporated in the model. We used a colon data set collected at Moffitt Cancer Center as an example of the study, and ranked genes based on the univariate Cox proportional hazards model. A set of top ranked genes was selected for evaluation. The selection was done by choosing the top k ranked genes for k = 1 to 12,500. An analysis indicated a considerable variation of classification outcomes when the number of top ranked genes was changed. We developed a predictive risk probability approach to accommodate this variation by identifying a range number of top ranked genes. For each number of top ranked genes, the procedure classifies each patient as having high risk (score = 1) or low risk (score = 0). The categorizations are then averaged, giving a risk score between 0 and 1, thus providing a ranking for the patient's need for further treatment. This approach was applied to the colon data set and demonstrated the strength of this approach by three criteria: First, a univariate Cox proportional hazards model showed a highly statistically significant level (log-rank χ2 statistics = 110 with p-value <10-16) for the predictive risk probability classification. Second, the survival tree model used the risk probability to partition patients into five risk groups showing a good separation of survival curves (log-rank χ2 statistics = 215). In addition, utilization of the risk group status identified a small set of risk genes that may be practical for biological validation. Third, analysis of resampling the risk probability suggested the variation pattern of the log-rank χ2 in the colon cancer data set was unlikely caused by chance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - CANCER patients
KW - CANCER treatment
KW - COLON cancer
KW - GENE expression
KW - GENETIC regulation
KW - Cancer risk classification
KW - Dimension reduction
KW - Log-rank test
KW - Survival tree model
KW - Top ranked genes
N1 - Accession Number: 34212762; Dung-Tsa Chen 1; Email Address: Dung-Tsa.Chen@moffitt.org Schell, Michael J. 1 Chen, James J. 2 Fulp, William J. 1 Eschrich, Steven 3 Yeatman, Timothy 4; Affiliation: 1: Biostatistics Division, Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA,Biostatistics Center and Department of Public Health, China Medical University, Taichung, Taiwan 3: Biomedical Informatics, Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida, USA 4: Surgery, Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, Florida, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p841; Subject Term: SAMPLING (Statistics); Subject Term: CANCER patients; Subject Term: CANCER treatment; Subject Term: COLON cancer; Subject Term: GENE expression; Subject Term: GENETIC regulation; Author-Supplied Keyword: Cancer risk classification; Author-Supplied Keyword: Dimension reduction; Author-Supplied Keyword: Log-rank test; Author-Supplied Keyword: Survival tree model; Author-Supplied Keyword: Top ranked genes; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 12p; Illustrations: 4 Diagrams, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400802277967
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baek, Songjoon
AU - Moon, Hojin
AU - Ahn, Hongshik
AU - Kodell, Ralph L.
AU - Lin, Chien-Ju
AU - Chen, James J.
T1 - Identifying High-Dimensional Biomarkers for Personalized Medicine via Variable Importance Ranking.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 853
EP - 868
PB - Taylor & Francis Ltd
SN - 10543406
AB - We apply robust classification algorithms to high-dimensional genomic data to find biomarkers, by analyzing variable importance, that enable a better diagnosis of disease, an earlier intervention, or a more effective assignment of therapies. The goal is to use variable importance ranking to isolate a set of important genes that can be used to classify life-threatening diseases with respect to prognosis or type to maximize efficacy or minimize toxicity in personalized treatment of such diseases. A ranking method and present several other methods to select a set of important genes to use as genomic biomarkers is proposed, and the performance of the selection procedures in patient classification by cross-validation is evaluated. The various selection algorithms are applied to published high-dimensional genomic data sets using several well-known classification methods. For each data set, a set of genes selected on the basis of variable importance that performed the best in classification is reported. That classification algorithm with the proposed ranking method is shown to be competitive with other selection methods for discovering genomic biomarkers underlying both adverse and efficacious outcomes for improving individualized treatment of patients for life-threatening diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANKING (Statistics)
KW - BIOCHEMICAL markers
KW - ORDER statistics
KW - PROGNOSIS
KW - DIAGNOSIS
KW - THERAPEUTICS
KW - CLINICAL medicine -- Mathematics
KW - MATHEMATICAL statistics
KW - Class prediction
KW - Cross-validation
KW - Ensembles
KW - Gene selection
KW - Risk profiling
N1 - Accession Number: 34212761; Baek, Songjoon 1 Moon, Hojin 2; Email Address: hmoon@csulb.edu Ahn, Hongshik 3 Kodell, Ralph L. 4 Lin, Chien-Ju 1 Chen, James J. 1; Affiliation: 1: Division of Personalized Nutrition and Medicine-Biometry Branch, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA 2: Department of Mathematics and Statistics, California State University, Long Beach, California, USA 3: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, USA 4: Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p853; Subject Term: RANKING (Statistics); Subject Term: BIOCHEMICAL markers; Subject Term: ORDER statistics; Subject Term: PROGNOSIS; Subject Term: DIAGNOSIS; Subject Term: THERAPEUTICS; Subject Term: CLINICAL medicine -- Mathematics; Subject Term: MATHEMATICAL statistics; Author-Supplied Keyword: Class prediction; Author-Supplied Keyword: Cross-validation; Author-Supplied Keyword: Ensembles; Author-Supplied Keyword: Gene selection; Author-Supplied Keyword: Risk profiling; Number of Pages: 16p; Illustrations: 2 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1080/10543400802278023
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rahman, Mohammad A.
AU - Lin, Karl K.
T1 - A Comparison of False Positive Rates of Peto and Poly-3 Methods for Long-Term Carcinogenicity Data Analysis Using Multiple Comparison Adjustment Method Suggested by Lin and Rahman.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 949
EP - 958
PB - Taylor & Francis Ltd
SN - 10543406
AB - Statistical analyses of two-year carcinogenicity data include tests for dose-response relationship (positive trend) among the increasing doses and pairwise comparisons of treated groups with control in tumor incidence by organ/tumor combination. There are two major concerns in analyzing carcinogenicity data, namely, adjustment for the difference in mortality due to drug toxicity and adjustment for the multiplicity due to multiple testing of trends and pairwise differences by organ tumor combination. A widely used method for testing dose-response relationship is the method suggested by Peto et al. (Peto test). The Peto test adjusts the mortality differences among treatment groups by partitioning the entire study period into several intervals, analyzing the data separately for each interval, and then combining them using the Mantel-Haenszel procedure. The denominator for the calculation of the proportion of tumor bearing animals is determined from the cause of death information tumor data. In later works, researchers have expressed concerns regarding the construction of suitable intervals for mortality adjustment. Also according to the opinion of many pathologists it is difficult to accurately specify retrospectively if a tumor is the real cause of death of an animal. This information may be imprecise. Hence, many times results of analysis using the Peto test are questioned due to the inaccurate cause of death information. An alternative to the Peto test was suggested by Bailer and Portier, popularly known as Poly-K test. Unlike the Peto test, this test does not need any arbitrary partitioning of the study period or the cause of death information. This test for trend in tumor incidence adjusts the differences in mortality among treatment groups by assigning a weight of less than one to an animal that died early without developing the tumor; and a weight of one to an animal that died with the tumor or survived to the end of the study. The sum of the assigned weights of animals in a treatment group is then used as the denominator for the calculation of proportion of tumor-bearing animals for the group. The less-than-one weight assigned to an animal is the fraction of the animal's surviving time in the study over the maximum time of the study with a power k. The power k of the fraction is determined by the distribution of tumor onset times of the tumor. The Poly-K test may have some advantages over the Peto test in the sense that it does not require the cause of death information, which is an essential part for the Peto test. However, the performance of the Poly-K test in controlling the false positive rate in comparison to the Peto test is unknown and of great interest in the regulatory environment. In this work the authors compared the overall false positive rates of the Peto and Poly-K tests using the Lin-Rahman multiple comparison adjustment based on some simulation results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STATISTICS
KW - CARCINOGENICITY
KW - DOSE-response relationship (Biochemistry)
KW - DRUGS -- Toxicology
KW - DEATH -- Causes
KW - CANCER
KW - BIOCHEMISTRY
KW - Carcinogenicity
KW - Dose response
KW - False positive rate
KW - Peto test
KW - Poly-K test
N1 - Accession Number: 34212775; Rahman, Mohammad A. 1; Email Address: mohammad.rahman@fda.hhs.gov Lin, Karl K. 1; Affiliation: 1: Division of Biometrics 6, Office of Biostatistics/Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p949; Subject Term: STATISTICS; Subject Term: CARCINOGENICITY; Subject Term: DOSE-response relationship (Biochemistry); Subject Term: DRUGS -- Toxicology; Subject Term: DEATH -- Causes; Subject Term: CANCER; Subject Term: BIOCHEMISTRY; Author-Supplied Keyword: Carcinogenicity; Author-Supplied Keyword: Dose response; Author-Supplied Keyword: False positive rate; Author-Supplied Keyword: Peto test; Author-Supplied Keyword: Poly-K test; Number of Pages: 10p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/10543400802287628
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yi Tsong
AU - Meiyu Shen
AU - Lostritto, Richard T.
AU - Poochikian, Guiragos K.
T1 - Parametric Two-Tier Sequential Quality Assurance Test of Delivery Dose Uniformity of Multiple-Dose Inhaler and Dry Powder Inhaler Drug Products.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 976
EP - 984
PB - Taylor & Francis Ltd
SN - 10543406
AB - The delivery dose uniformity is one of the most critical requirements of dry powder inhaler and metered dose inhaler products. In 1998, the U.S. Food and Drug Administration recommended a two-tier acceptance sampling plan in the Draft Guidance of Metered Dose Inhaler and Dry Powder Inhaler Drug Products Chemistry, Manufacturing and Controls. The two-tier procedure is a modification of the United States Pharmacopeia (USP) sampling plan of dose content uniformity. It employed a zero tolerance criterion. In addition, it has a near-zero probability acceptance at the second tier. In this article, a two-tier sequential tolerance interval approach is proposed that is equivalent to a two-tier two one-sided testing procedure. It controls the probability of the product delivering below a prespecified effective dose and the probability of the product delivering over a prespecified safety dose. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INHALERS
KW - DOSAGE forms of drugs
KW - DRUG delivery devices
KW - DRUG laws & regulations
KW - TOTAL quality management
KW - UNITED States
KW - Delivered dose uniformity
KW - Double one-sided test
KW - FDA draft guidance method
KW - Tolerance interval
KW - Two-tier group sequential
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 34212773; Yi Tsong 1; Email Address: yi.tsong@fda.hhs.gov Meiyu Shen 1 Lostritto, Richard T. 2 Poochikian, Guiragos K. 2; Affiliation: 1: Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA 2: Office of New Drug Quality Assurance/Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p976; Subject Term: INHALERS; Subject Term: DOSAGE forms of drugs; Subject Term: DRUG delivery devices; Subject Term: DRUG laws & regulations; Subject Term: TOTAL quality management; Subject Term: UNITED States; Author-Supplied Keyword: Delivered dose uniformity; Author-Supplied Keyword: Double one-sided test; Author-Supplied Keyword: FDA draft guidance method; Author-Supplied Keyword: Tolerance interval; Author-Supplied Keyword: Two-tier group sequential; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 9p; Illustrations: 2 Diagrams, 2 Graphs; Document Type: Article
L3 - 10.1080/10543400802287222
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhong, Jinglin
AU - Lee, Kathy
AU - Tsong, Yi
T1 - Statistical Assessment of Analytical Method Transfer.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2008/09//Sep/Oct2008
VL - 18
IS - 5
M3 - Article
SP - 1005
EP - 1012
PB - Taylor & Francis Ltd
SN - 10543406
AB - Analytical method transfer is an important part of analytical method development and maintenance. The current common practice of analytical method transfer is based on the equivalence of the means between the original laboratory and the receiving laboratory. However, for some assays the most scientifically sound approach would be to show the equivalency of individual sample readings between the two laboratories. In this study, statistical approaches such as limit of agreement, total deviation index, and tolerance interval approach to address individual equivalence between laboratories are discussed. Using a tolerance interval approach that is equivalent to the two one-sided hypothesis testing is proposed. These approaches are compared with each other and also with the mean equivalence approach on their statistical properties. Examples are presented to illustrate each analysis approach and the comparisons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL analysis
KW - TECHNOLOGY -- Study & teaching
KW - TECHNOLOGY transfer
KW - SCIENCE classrooms & equipment
KW - MEDICAL technology
KW - QUANTITATIVE research
KW - LABORATORIES
KW - Analytical method transfer
KW - Concordance correlation coefficient
KW - Double one-sided test
KW - Tolerance interval
N1 - Accession Number: 34212770; Zhong, Jinglin 1 Lee, Kathy 1 Tsong, Yi 1; Email Address: yi.tsong@fda.hhs.gov; Affiliation: 1: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Sep/Oct2008, Vol. 18 Issue 5, p1005; Subject Term: MATHEMATICAL analysis; Subject Term: TECHNOLOGY -- Study & teaching; Subject Term: TECHNOLOGY transfer; Subject Term: SCIENCE classrooms & equipment; Subject Term: MEDICAL technology; Subject Term: QUANTITATIVE research; Subject Term: LABORATORIES; Author-Supplied Keyword: Analytical method transfer; Author-Supplied Keyword: Concordance correlation coefficient; Author-Supplied Keyword: Double one-sided test; Author-Supplied Keyword: Tolerance interval; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; Number of Pages: 8p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1080/10543400802287347
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GARBER, ERIC A. E.
AU - WALKER, JENNIFER L.
AU - O'BRIEN, THOMAS W.
T1 - Detection of Abrin in Food Using Enzyme-Linked Immunosorbent Assay and Electrochemiluminescence Technologies.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/09//
VL - 71
IS - 9
M3 - Article
SP - 1868
EP - 1874
SN - 0362028X
AB - Abrin is a toxic ribosome-inactivating protein present in beans of Abrus precatorius, also known as rosary peas. The possibility that abrin could be used to adulterate food has made the development of assays for the detection of abrin a priority. Rabbit-derived polyclonal antibodies and mouse monoclonal antibodies were prepared against a mixture of abrin isozymes. The specificity and cross-reactivity of the antibodies were evaluated against a challenge library of 40 grains, nuts, legumes, and foods. An enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescence (ECL)-based assay were assembled and optimized. Polyclonal (capture) and polyclonal (detection) ELISAs, polyclonal and monoclonal ELISAs, and polyclonal and monoclonal ECL assays had limits of detection (LODs) of 0.1 to 0.5 ng/ml for abrin in buffer. The LOD for abrin dissolved into juices, dairy products, soda, chocolate drink, and condiments and analyzed with the ECL assay ranged from 0.1 to 0.5 ng/ml in the analytical sample. In contrast, the LODs for the ELISAs ranged from 0.5 to 10 ng/ml in the analytical sample. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Peas
KW - Proteins
KW - Enzyme-linked immunosorbent assay
KW - Monoclonal antibodies
KW - Isoenzymes
N1 - Accession Number: 34788066; GARBER, ERIC A. E. 1; Email Address: eric.garber@fda.hhs.gov; WALKER, JENNIFER L. 2; O'BRIEN, THOMAS W. 2; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740; 2: Tetracore, Inc., Rockville, Maryland 20850, USA; Issue Info: Sep2008, Vol. 71 Issue 9, p1868; Thesaurus Term: Peas; Subject Term: Proteins; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Monoclonal antibodies; Subject Term: Isoenzymes; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111130 Dry Pea and Bean Farming; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GARBER, ERIC A. E.
AU - WALKER, JENNIFER L.
AU - O'BRIEN, THOMAS W.
T1 - Detection of Abrin in Food Using Enzyme-Linked Immunosorbent Assay and Electrochemiluminescence Technologies.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/09//
VL - 71
IS - 9
M3 - Article
SP - 1868
EP - 1874
SN - 0362028X
AB - Abrin is a toxic ribosome-inactivating protein present in beans of Abrus precatorius, also known as rosary peas. The possibility that abrin could be used to adulterate food has made the development of assays for the detection of abrin a priority. Rabbit-derived polyclonal antibodies and mouse monoclonal antibodies were prepared against a mixture of abrin isozymes. The specificity and cross-reactivity of the antibodies were evaluated against a challenge library of 40 grains, nuts, legumes, and foods. An enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescence (ECL)-based assay were assembled and optimized. Polyclonal (capture) and polyclonal (detection) ELISAs, polyclonal and monoclonal ELISAs, and polyclonal and monoclonal ECL assays had limits of detection (LODs) of 0.1 to 0.5 ng/ml for abrin in buffer. The LOD for abrin dissolved into juices, dairy products, soda, chocolate drink, and condiments and analyzed with the ECL assay ranged from 0.1 to 0.5 ng/ml in the analytical sample. In contrast, the LODs for the ELISAs ranged from 0.5 to 10 ng/ml in the analytical sample. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEINS
KW - PEAS
KW - ENZYME-linked immunosorbent assay
KW - MONOCLONAL antibodies
KW - ISOENZYMES
N1 - Accession Number: 34788066; GARBER, ERIC A. E. 1; Email Address: eric.garber@fda.hhs.gov WALKER, JENNIFER L. 2 O'BRIEN, THOMAS W. 2; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740 2: Tetracore, Inc., Rockville, Maryland 20850, USA; Source Info: Sep2008, Vol. 71 Issue 9, p1868; Subject Term: PROTEINS; Subject Term: PEAS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: MONOCLONAL antibodies; Subject Term: ISOENZYMES; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111130 Dry Pea and Bean Farming; NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GARBER, ERIC A. E.
T1 - Toxicity and Detection of Ricin and Abrin in Beverages.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/09//
VL - 71
IS - 9
M3 - Article
SP - 1875
EP - 1883
SN - 0362028X
AB - The oral and intraperitoneal (i.p.) toxicities to female BALB/c mice of ricin and abrin in phosphate-buffered saline (PBS), spring water, apple juice, and half-and-half (only oral) were examined after brief (2 h) and prolonged (11 to 13 days) storage. The ricin and abrin samples prepared in PBS had oral toxicities consistent with those previous studies, indicating oral and i.p. 50% lethal doses of > 1 mg/kg of body weight and between 2 and 20 µg/kg of body weight, respectively. The toxicities of ricin and abrin in PBS were greater than those in apple juice and water. The oral toxicity of ricin and abrin in half-and-half appeared comparable to or less than that observed for the toxins in water. Spiked samples stored for a maximum of 11 days (13 for the abrin samples) at 4°C induced similar numbers of fatalities as did samples stored for only 2 h. Enzyme-linked immunosorbent assays of the samples administered by i.p. injection indicated a decrease in detectable toxin at 0.5 µg/ml. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ricin
KW - Toxins
KW - Beverages
KW - Proteins
KW - Enzyme-linked immunosorbent assay
N1 - Accession Number: 34788067; GARBER, ERIC A. E. 1; Email Address: eric.garber@fda.hhs.gov; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740, USA; Issue Info: Sep2008, Vol. 71 Issue 9, p1875; Thesaurus Term: Ricin; Thesaurus Term: Toxins; Subject Term: Beverages; Subject Term: Proteins; Subject Term: Enzyme-linked immunosorbent assay; Number of Pages: 9p; Illustrations: 5 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DE JESÚS, ANTONIO J.
AU - WHITING, RICHARD C.
T1 - Modeling the Physiological State of the Inoculum and CO2 Atmosphere on the Lag Phase and Growth Rate of Listeria monocytogenes.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/09//
VL - 71
IS - 9
M3 - Article
SP - 1915
EP - 1918
SN - 0362028X
AB - In previous studies, the growth of L. monocytogenes has been modeled under different CO2 headspace concentrations; however, the inoculum cells were always in the stationary phase. In this study, the growth of L. monocytogenes under different CO2 concentrations as affected by the physiological state of the cells was investigated. Exponential-growth-phase, stationary-phase, dried, and starved cells were prepared and inoculated at 5°C into brain heart infusion broths that had been preequilibrated under atmospheres of 0, 20, 40, 60, or 80% CO2 (the balance was N2). Lag-phase duration times (LDTs) and exponential growth rates were determined by enumerating cells at appropriate time intervals and by fitting the data to a three-phase linear function that has a lag period before the initiation of exponential growth. Longer LDTs were observed as the CO2 concentration increased, with no growth observed at 80% CO2. For example, the LDTs for exponential-phase, stationary-phase, starved, and dried cells were 2.21, 8.27, 9.17, and 9.67 days, respectively, under the 40% COz atmosphere. In general, exponential-growthphase cells had the shortest LDT followed by starved cells and stationary-phase cells. Dried cells had the longest LDT. Exponential growth rates decreased as the CO2 concentrations increased. Once exponential growth was attained, no retained differences among the various initial physiological states of the cells for any of the atmospheres were observed in the exponential growth rates. The exponential growth rates under 0, 20, 40, 60, and 80% CO2 averaged 0.39, 0.37, 0.23, 0.23, and 0.0 log CFU/day, respectively. Dimensionless factors were calculated that describe the inhibitory action of CO2 on the LDTs and exponential growth rates for the various physiological states. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - Carbon dioxide
KW - Listeria
KW - Listeria monocytogenes
KW - Cells
N1 - Accession Number: 34788073; DE JESÚS, ANTONIO J. 1; Email Address: antonio.dejesus@fda.hhs.gov; WHITING, RICHARD C. 1; Affiliations: 1: U.S. Food and Drug Administration, Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Sep2008, Vol. 71 Issue 9, p1915; Thesaurus Term: Food pathogens; Thesaurus Term: Carbon dioxide; Thesaurus Term: Listeria; Subject Term: Listeria monocytogenes; Subject Term: Cells; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DE JESÚS, ANTONIO J.
AU - WHITING, RICHARD C.
T1 - Modeling the Physiological State of the Inoculum and CO2 Atmosphere on the Lag Phase and Growth Rate of Listeria monocytogenes.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/09//
VL - 71
IS - 9
M3 - Article
SP - 1915
EP - 1918
SN - 0362028X
AB - In previous studies, the growth of L. monocytogenes has been modeled under different CO2 headspace concentrations; however, the inoculum cells were always in the stationary phase. In this study, the growth of L. monocytogenes under different CO2 concentrations as affected by the physiological state of the cells was investigated. Exponential-growth-phase, stationary-phase, dried, and starved cells were prepared and inoculated at 5°C into brain heart infusion broths that had been preequilibrated under atmospheres of 0, 20, 40, 60, or 80% CO2 (the balance was N2). Lag-phase duration times (LDTs) and exponential growth rates were determined by enumerating cells at appropriate time intervals and by fitting the data to a three-phase linear function that has a lag period before the initiation of exponential growth. Longer LDTs were observed as the CO2 concentration increased, with no growth observed at 80% CO2. For example, the LDTs for exponential-phase, stationary-phase, starved, and dried cells were 2.21, 8.27, 9.17, and 9.67 days, respectively, under the 40% COz atmosphere. In general, exponential-growthphase cells had the shortest LDT followed by starved cells and stationary-phase cells. Dried cells had the longest LDT. Exponential growth rates decreased as the CO2 concentrations increased. Once exponential growth was attained, no retained differences among the various initial physiological states of the cells for any of the atmospheres were observed in the exponential growth rates. The exponential growth rates under 0, 20, 40, 60, and 80% CO2 averaged 0.39, 0.37, 0.23, 0.23, and 0.0 log CFU/day, respectively. Dimensionless factors were calculated that describe the inhibitory action of CO2 on the LDTs and exponential growth rates for the various physiological states. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - FOOD pathogens
KW - CARBON dioxide
KW - CELLS
KW - LISTERIA
N1 - Accession Number: 34788073; DE JESÚS, ANTONIO J. 1; Email Address: antonio.dejesus@fda.hhs.gov WHITING, RICHARD C. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Source Info: Sep2008, Vol. 71 Issue 9, p1915; Subject Term: LISTERIA monocytogenes; Subject Term: FOOD pathogens; Subject Term: CARBON dioxide; Subject Term: CELLS; Subject Term: LISTERIA; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 4p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Y. S.
AU - Park, S. J.
AU - Lee, E. J.
AU - Cerbo, R. M.
AU - Lee, S. M.
AU - Ryu, C. H.
AU - Kim, G. S.
AU - Kim, J. O.
AU - Ha, Y. L.
T1 - Antibacterial Compounds from Rose Bengal-Sensitized Photooxidation of β-Caryophyllene.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2008/09//
VL - 73
IS - 7
M3 - Article
SP - C540
EP - C545
SN - 00221147
AB - The bactericidal activity of β-caryophyllene photooxidized in acetonitrile was examined for 5 Gram-positive and 4 Gram-negative foodborne bacteria. The β-caryophyllene (5 × 10−3 M) was photooxidized in acetonitrile containing Rose Bengal (6.25 × 10−4 M) for 24 h under fluorescent light. The antimicrobial activities of samples were determined by the agar-disc diffusion method. Active compounds from the photooxidized β-caryophyllene were isolated by silica gel open-column chromatography in conjunction with recyclic high-performance liquid chromatography (HPLC), and were identified by infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy. The antimicrobial activity of the photooxidized β-caryophyllene was strongly enhanced against Streptococcus aureus and Vibrio parahaemolyticus, relative to that of β-caryophyllene, but was weakly enhanced against other tested bacteria. The photooxidized β-caryophyllene contained 3 active compounds specific for these 2 bacteria, and the compounds were identified as 5-α-hydroxycaryophylla-4(12),8(13)-diene, 5-α-hydroxycaryophylla-3(4),8(13)-diene, and 5-β-hydroxycaryophylla-3(4),8(13)-diene. The efficacies of these compounds were similar, but the efficacy of 5-β-hydroxycaryophylla-3(4),8(13)-diene was slightly higher than that of the other 2 compounds. The results suggest that the antibacterial activities of β-caryophyllene for S. aureus and V. parahaemolyticus could be enhanced by dye-sensitized photooxidation, and the photooxidized β-caryophyllene and the isolated individual compounds could be useful antimicrobial agents to control the growth of S. aureus and V. parahaemolyticus in certain food systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETONITRILE
KW - GRAM-positive bacteria
KW - FOOD pathogens
KW - PHOTOOXIDATIVE stress
KW - STAPHYLOCOCCUS aureus
KW - ANTI-infective agents
KW - VIBRIO parahaemolyticus
KW - β-caryophyllene
KW - β-caryophyllene
KW - antimicrobial activity
KW - photooxidation
KW - S. aureus
KW - V. parahaemolyticus
N1 - Accession Number: 34138285; Kim, Y. S. 1 Park, S. J. 2 Lee, E. J. 3 Cerbo, R. M. 1 Lee, S. M. 1 Ryu, C. H. 1 Kim, G. S. 4 Kim, J. O. 5 Ha, Y. L. 1; Email Address: ylha@gnu.ac.kr; Affiliation: 1: Division of Applied Life Sciences (BK21 Program), Graduate School, and Inst. of Agriculture & Life Science 2: College of Oriental Medicine, Daegu Haany Univ., Gyeongsan 712-715, Republic of Korea 3: Korea Food and Drug Administration, Seoul 122-704, Republic of Korea 4: School of Veterinary Medicine, Gyeongsang Natl. Univ., Jinju 660-701, Republic of Korea 5: HK Biotech Co. Ltd., Jinju 660-972, Republic of Korea; Source Info: Sep2008, Vol. 73 Issue 7, pC540; Subject Term: ACETONITRILE; Subject Term: GRAM-positive bacteria; Subject Term: FOOD pathogens; Subject Term: PHOTOOXIDATIVE stress; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: ANTI-infective agents; Subject Term: VIBRIO parahaemolyticus; Author-Supplied Keyword: β-caryophyllene; Author-Supplied Keyword: β-caryophyllene; Author-Supplied Keyword: antimicrobial activity; Author-Supplied Keyword: photooxidation; Author-Supplied Keyword: S. aureus; Author-Supplied Keyword: V. parahaemolyticus; Number of Pages: 6p; Illustrations: 3 Black and White Photographs, 3 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1750-3841.2008.00879.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eilat-Adar, Sigal
AU - Jiaqiong Xu
AU - Zephier, Ellie
AU - O'leary, Veronica
AU - Howard, Barbara V.
AU - Resnick, Helaine E.
T1 - Adherence to Dietary Recommendations for Saturated Fat, Fiber, and Sodium Is Low in American Indians and Other U.S. Adults with Diabetes.
JO - Journal of Nutrition
JF - Journal of Nutrition
Y1 - 2008/09//
VL - 138
IS - 9
M3 - Article
SP - 1699
EP - 1704
SN - 00223166
AB - The objective of this article was to evaluate how well American Indians with diabetes met dietary recommendations and to compare adherence to dietary recommendations with those of U.S. adults with diabetes in the NHANES. Dietary intake in both studies was assessed using a 24-h recall questionnaire. Dietary intakes were evaluated against American Diabetes Association (ADA) dietary recommendations. The analysis sample consisted of 1008 participants from the Strong Heart Study (SHS) examined from 1997 to 1999 and 373 participants from NHANES examined from 1999 to 2000, all with diabetes. In both samples, intake of protein, PUFA, monounsaturated fatty acids, and carbohydrates met the 1997 ADA dietary recommendations. However, intakes of SEA as well as sodium were higher and dietary fiber intake was lower than recommended. In the SHS and NHANES, only 4.6 and 8.5% of persons with diabetes met recommendations for both SFA and fiber (P = 0.02), respectively. However, only 8.3% of the NHANES sample met the 2006 recommendations for SEA and fiber and none of the SHS sample met those recommendations. This cross-sectional study shows low adherence to ADA dietary recommendations for saturated fat, fiber, and sodium by American Indians with diabetes and by the broader U.S. population of adults with diabetes and shows that for American Indians with diabetes, programs to decrease SFA and increase fiber intakes are warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nutrition is the property of American Society for Nutrition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nutrition -- Requirements
KW - Diabetics
KW - Saturated fatty acids in human nutrition
KW - Fiber in human nutrition
KW - Native Americans
KW - United States
N1 - Accession Number: 34350989; Eilat-Adar, Sigal 1; Email Address: eiIatsi@017.net.iI; Jiaqiong Xu 2; Zephier, Ellie 3; O'leary, Veronica 4; Howard, Barbara V. 5; Resnick, Helaine E. 6,7; Affiliations: 1: Zinman College for Physical Education and Sports, Wingate Institute, 42902 Netanya, Israel; Department of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel; 2: Center for Biostatistics, Methodist Hospital Research Institute, Houston, TX; 3: Aberdeen Area Indian Health Service, Aberdeen, SD 57401; 4: Wagner Indian Health Service, Diabetes Prevention Project, Wagner, SD 57380; 5: Medstar Research Institute, Hyattsville, MD 20783; 6: American Association of Homes and Services for the Aging, Washington, DC; 7: Georgetown University, Washington, DC 20057; Issue Info: Sep2008, Vol. 138 Issue 9, p1699; Subject Term: Nutrition -- Requirements; Subject Term: Diabetics; Subject Term: Saturated fatty acids in human nutrition; Subject Term: Fiber in human nutrition; Subject Term: Native Americans; Subject: United States; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rengasamy, Samy
AU - King, William P.
AU - Eimer, Benjamin C.
AU - Shaffer, Ronald E.
T1 - Filtration Performance of NIOSH-Approved N95 and P100 Filtering Facepiece Respirators Against 4 to 30 Nanometer-Size Nanoparticles.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/09//
VL - 5
IS - 9
M3 - Article
SP - 556
EP - 564
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study investigated the filtration performance of NIOSH-approved N95 and P100 filtering facepiece respirators (FFR) against six different monodisperse silver aerosol particles in the range of 4-30 nm diameter. A particle test system was developed and standardized for measuring the penetration of monodisperse silver particles. For respirator testing, five models of N95 and two models of P100 filtering facepiece respirators were challenged with monodisperse silver aerosol particles of 4, 8, 12, 16, 20, and 30 nm at 85 L/min flow rate and percentage penetrations were measured. Consistent with single-fiber filtration theory, N95 and P100 respirators challenged with silver monodisperse particles showed a decrease in percentage penetration with a decrease in particle diameter down to 4 nm. Penetrations less than 1 particle/30 min for 4-8 nm particles for one P100 respirator model, and 4-12 nm particles for the other P100 model, were observed. Experiments were also carried out with larger than 20 nm monodisperse NaCl particles using a TSI 3160 Fractional Efficiency Tester. NaCl aerosol penetration levels of 20 nm and 30 nm (overlapping sizes) particles were compared with silver aerosols of the same sizes by a three-way ANOVA analysis. A significant (p < 0.001) difference between NaCl and silver aerosol penetration levels was obtained after adjusting for particle sizes and manufacturers. A significant (p = 0.001) interaction with manufacturers indicated the difference in NaCl, and silver aerosol penetrations were not the same across manufacturers. The two aerosols had the same effect across 20 nm and 30 nm sizes as shown by the absence of any significant (p = 0.163) interaction with particle sizes. In the case of P100 FFRs, a significant (p < 0.001) difference between NaCl and silver aerosol (20 nm and 30 nm) penetrations was observed for both respirator models tested. The filtration data for 4-30 nm monodisperse particles supports previous studies that indicate NIOSH-approved air-purifying respirators provide expected levels of filtration protection against nanoparticles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Filters & filtration
KW - Air -- Purification
KW - Aerosols (Sprays)
KW - Breathing apparatus
KW - Nanoparticles
KW - Salt
KW - United States
KW - monodisperse aerosol
KW - NaCl particles
KW - nanoparticle
KW - particle penetration
KW - respirator
KW - silver particles
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 34116070; Rengasamy, Samy 1; Email Address: rda5@cdc.gov; King, William P. 1; Eimer, Benjamin C. 2; Shaffer, Ronald E. 1; Affiliations: 1: National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; 2: EG&G Technical Services, Inc., Pittsburgh, Pennsylvania; Issue Info: Sep2008, Vol. 5 Issue 9, p556; Thesaurus Term: Industrial safety; Thesaurus Term: Filters & filtration; Thesaurus Term: Air -- Purification; Thesaurus Term: Aerosols (Sprays); Subject Term: Breathing apparatus; Subject Term: Nanoparticles; Subject Term: Salt; Subject: United States; Author-Supplied Keyword: monodisperse aerosol; Author-Supplied Keyword: NaCl particles; Author-Supplied Keyword: nanoparticle; Author-Supplied Keyword: particle penetration; Author-Supplied Keyword: respirator; Author-Supplied Keyword: silver particles ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 311940 Seasoning and dressing manufacturing; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1080/15459620802275387
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34116070&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105815824
T1 - Filtration performance of NIOSH-approved N95 and P100 filtering facepiece respirators against 4 to 30 nanometer-size nanoparticles.
AU - Rengasamy S
AU - King WP
AU - Eimer BC
AU - Shaffer RE
Y1 - 2008/09//
N1 - Accession Number: 105815824. Language: English. Entry Date: 20080912. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Metals
KW - Occupational Health
KW - Respiratory Protective Devices
KW - Filtration
KW - National Institute for Occupational Safety and Health
KW - Particle Size
KW - Silver
KW - United States
SP - 556
EP - 564
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study investigated the filtration performance of NIOSH-approved N95 and P100 filtering facepiece respirators (FFR) against six different monodisperse silver aerosol particles in the range of 4-30 nm diameter. A particle test system was developed and standardized for measuring the penetration of monodisperse silver particles. For respirator testing, five models of N95 and two models of P100 filtering facepiece respirators were challenged with monodisperse silver aerosol particles of 4, 8, 12, 16, 20, and 30 nm at 85 L/min flow rate and percentage penetrations were measured. Consistent with single-fiber filtration theory, N95 and P100 respirators challenged with silver monodisperse particles showed a decrease in percentage penetration with a decrease in particle diameter down to 4 nm. Penetrations less than 1 particle/30 min for 4-8 nm particles for one P100 respirator model, and 4-12 nm particles for the other P100 model, were observed. Experiments were also carried out with larger than 20 nm monodisperse NaCl particles using a TSI 3160 Fractional Efficiency Tester. NaCl aerosol penetration levels of 20 nm and 30 nm (overlapping sizes) particles were compared with silver aerosols of the same sizes by a three-way ANOVA analysis. A significant (p < 0.001) difference between NaCl and silver aerosol penetration levels was obtained after adjusting for particle sizes and manufacturers. A significant (p = 0.001) interaction with manufacturers indicated the difference in NaCl, and silver aerosol penetrations were not the same across manufacturers. The two aerosols had the same effect across 20 nm and 30 nm sizes as shown by the absence of any significant (p = 0.163) interaction with particle sizes. In the case of P100 FFRs, a significant (p < 0.001) difference between NaCl and silver aerosol (20 nm and 30 nm) penetrations was observed for both respirator models tested. The filtration data for 4-30 nm monodisperse particles supports previous studies that indicate NIOSH-approved air-purifying respirators provide expected levels of filtration protection against nanoparticles.
SN - 1545-9624
AD - Technology ResearchBranch, National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania 15236, USA. rda5@cdc.gov
U2 - PMID: 18607812.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109850161
T1 - The persistent variability of quality.
AU - Brady J
AU - Ho K
AU - Clancy CM
Y1 - 2008/09//2008 Sep
N1 - Accession Number: 109850161. Language: English. Entry Date: 20081128. Revision Date: 20151008. Publication Type: Journal Article; editorial. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 101233393.
KW - Quality Improvement -- Trends
KW - Quality of Health Care -- Standards
KW - Residence Characteristics
KW - Clinical Indicators -- Standards
KW - Geographic Factors
KW - Reports
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 127
EP - 128
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 4
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tabasi, Simin Hassannejad
AU - Fahmy, Raafat
AU - Bensley, Dennis
AU - O'Brien, Charles
AU - Hoag, Stephen W.
T1 - Quality by design, part I: Application of NIR spectroscopy to monitor tablet manufacturing process.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/09//
VL - 97
IS - 9
M3 - Article
SP - 4040
EP - 4051
SN - 00223549
AB - To monitor tableting production using near infrared (NIR) spectroscopy, chemometric models were developed to analyze peak compression force, crushing strength and content uniformity. To measure tablet content uniformity, orbifloxacin tablets with drug content ranging from 60 to 90 mg were made and analyzed using ultraviolet (UV) and NIR spectroscopy. To assess the compression force and crushing strength, several batches of tablets were made on a Stokes B2 rotary tablet press and compression force was varied from 360 to 3500 lb. Principal component analysis (PCA) was used to identify tablets with regular and capped tablets breakage patterns. Comparison of statistical parameters showed that partial least squares (PLS) models gave better fit than the multiple linear regression (MLR) models. The best fit PLS models had a standard error of calibration (SEC) and a standard error of prediction (SEP) for content uniformity of 1.13 and 1.36 mg; for compression force of 69.86 and 59.48 lb and for crushing strength 0.55 kP and 0.57 kP, respectively. NIR spectroscopy in combination with multivariate modeling is a rapid and nondestructive technique that could reliably predict content uniformity, compression force and crushing strength for orbifloxacin tablets. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4040–4051, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL technology
KW - TABLETS (Medicine)
KW - DRUGS -- Coatings
KW - CHEMOMETRICS
KW - NEAR infrared spectroscopy
KW - ULTRAVIOLET spectroscopy
KW - REGRESSION analysis
KW - Chemometric modeling
KW - compression force
KW - crushing strength
KW - near infrared spectroscopy
KW - NIR
KW - orbifloxacin
KW - partial least square regression
KW - PLS
KW - quality by design
KW - vibrational spectroscopy
N1 - Accession Number: 33468083; Tabasi, Simin Hassannejad 1,2 Fahmy, Raafat 3 Bensley, Dennis 3 O'Brien, Charles 3 Hoag, Stephen W. 1; Email Address: shoag@rx.umaryland.edu; Affiliation: 1: School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, Maryland 21201, USA 2: Perrigo Company, Research and Development, 655 Hooker Rd., Allegan, MI 49010, USA 3: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, FDA, Rockville, Maryland 20855, USA; Source Info: Sep2008, Vol. 97 Issue 9, p4040; Subject Term: PHARMACEUTICAL technology; Subject Term: TABLETS (Medicine); Subject Term: DRUGS -- Coatings; Subject Term: CHEMOMETRICS; Subject Term: NEAR infrared spectroscopy; Subject Term: ULTRAVIOLET spectroscopy; Subject Term: REGRESSION analysis; Author-Supplied Keyword: Chemometric modeling; Author-Supplied Keyword: compression force; Author-Supplied Keyword: crushing strength; Author-Supplied Keyword: near infrared spectroscopy; Author-Supplied Keyword: NIR; Author-Supplied Keyword: orbifloxacin; Author-Supplied Keyword: partial least square regression; Author-Supplied Keyword: PLS; Author-Supplied Keyword: quality by design; Author-Supplied Keyword: vibrational spectroscopy; Number of Pages: 12p; Illustrations: 1 Diagram, 7 Charts, 6 Graphs; Document Type: Article
L3 - 10.1002/jps.21303
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tabasi, Simin Hassannejad
AU - Fahmy, Raafat
AU - Bensley, Dennis
AU - O'Brien, Charles
AU - Hoag, Stephen W.
T1 - Quality by design, part II: Application of NIR spectroscopy to monitor the coating process for a pharmaceutical sustained release product.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/09//
VL - 97
IS - 9
M3 - Article
SP - 4052
EP - 4066
SN - 00223549
AB - Ammonio methacrylate copolymers are commercially available as Eudragit RL/RS; they differ in the degree of quaternary ammonium group substitution, which gives them different permeabilities. These closely related polymers can be combined in various ratios to control release rate; consequently, release rate is controlled by the polymer composition and coating thickness. Therefore, predicting drug release from methacrylate copolymers using near infrared spectroscopy (NIRS) can be technically difficult. Thus, the objective of this study is to use NIRS to develop multivariate calibration models to predict tablet coat thickness and release rate for tablets coated with varying polymer ratios. A series of sustained release orbifloxacin formulations were developed with varying polymer ratios. Partial least squares (PLS) models were developed to predict coat thickness; samples from these formulations were pooled and a combined calibration was generated. To assess dissolution, tablets were coated using Eudragit RL and RS with ratios of 0:5, 1:4, 2:3, 3:2, 4:1, and 5:0. The amount released at set time-points was used to build PLS models. For the first time, NIRS has been successfully used to monitor Eudragit polymer coat thickness and drug release from tablets coated with various RL:RS ratios, which demonstrates the potential of NIRS as tool for coating process. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4052–4066, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL technology
KW - CHEMOMETRICS
KW - NEAR infrared spectroscopy
KW - DRUGS -- Coatings
KW - DRUGS -- Solubility
KW - POLYMERS in medicine
KW - chemometrics
KW - coating
KW - coating thickness
KW - dissolution profile
KW - multivariate calibration
KW - near infrared spectroscopy (NIRS)
KW - prediction
N1 - Accession Number: 33468082; Tabasi, Simin Hassannejad 1,2 Fahmy, Raafat 3 Bensley, Dennis 3 O'Brien, Charles 3 Hoag, Stephen W. 1; Email Address: shoag@rx.umaryland.edu; Affiliation: 1: School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, Maryland 21201, USA 2: Perrigo Company, Research and Development, 655 Hooker Rd.,Allegan, MI 49010, USA 3: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, FDA, Rockville, Maryland 20855, USA; Source Info: Sep2008, Vol. 97 Issue 9, p4052; Subject Term: PHARMACEUTICAL technology; Subject Term: CHEMOMETRICS; Subject Term: NEAR infrared spectroscopy; Subject Term: DRUGS -- Coatings; Subject Term: DRUGS -- Solubility; Subject Term: POLYMERS in medicine; Author-Supplied Keyword: chemometrics; Author-Supplied Keyword: coating; Author-Supplied Keyword: coating thickness; Author-Supplied Keyword: dissolution profile; Author-Supplied Keyword: multivariate calibration; Author-Supplied Keyword: near infrared spectroscopy (NIRS); Author-Supplied Keyword: prediction; Number of Pages: 15p; Illustrations: 2 Diagrams, 6 Charts, 12 Graphs; Document Type: Article
L3 - 10.1002/jps.21307
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tabasi, Simin Hassannejad
AU - Fahmy, Raafat
AU - Bensley, Dennis
AU - O'Brien, Charles
AU - Hoag, Stephen W.
T1 - Quality by design, part III: Study of curing process of sustained release coated products using NIR spectroscopy.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/09//
VL - 97
IS - 9
M3 - Article
SP - 4067
EP - 4086
SN - 00223549
AB - This study investigated the potential of near infrared spectroscopy (NIRS) to assess film coat curing for tablets coated with methacrylate copolymers. The ability of NIRS to monitor film coat curing was studied and compared to conventional methods like differential scanning calorimetry (DSC) and hot-stage microscopy (HSOM). This study showed that variation in the curing temperature and duration affected the NIR spectra for all formulations. These results and the DSC and HSOM results showed that the spectral changes are due to polymer curing. In addition, glass beads, theophylline and orbifloxacin tablets were coated using Eudragit RL, RS, and L 30-D with varying ratios. Principal component analysis (PCA) was performed on the NIR spectra to investigate the effect of curing time and temperature on cast films, uncoated tablets, coated tablets and coated glass beads. Score plots showed that curing duration and temperature affected coated glass beads, uncoated and coated tablets significantly. The amount of drug released at 250 min, and the NIR spectra of cured tablets were used to develop and validate a 7-factor partial least square (PLS) regression calibration for theophylline tablets coated with Eudragit RL:RS 30-D (1:4). This study demonstrated the potential of NIRS in film coat curing and release monitoring. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:4067–4086, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEAR infrared spectroscopy
KW - SURFACE coatings
KW - CURING
KW - METHYL methacrylate
KW - COPOLYMERS
KW - CALORIMETRY
KW - MICROSCOPY
KW - chemometrics
KW - dissolution profile
KW - film coat curing
KW - multivariate analysis
KW - NIR spectroscopy
KW - prediction
KW - standard error of calibration
KW - standard error of prediction
KW - tablet coating
N1 - Accession Number: 33468078; Tabasi, Simin Hassannejad 1,2 Fahmy, Raafat 3 Bensley, Dennis 3 O'Brien, Charles 3 Hoag, Stephen W. 1; Email Address: shoag@rx.umaryland.edu; Affiliation: 1: School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, Maryland 21201, USA 2: Perrigo Company, Research and Development, 655 Hooker Rd., Allegan, Michigan 49010, USA 3: Office of New Animal Drug Evaluation, Center for Veterinary Medicine, FDA, Rockville, Maryland 20855, USA; Source Info: Sep2008, Vol. 97 Issue 9, p4067; Subject Term: NEAR infrared spectroscopy; Subject Term: SURFACE coatings; Subject Term: CURING; Subject Term: METHYL methacrylate; Subject Term: COPOLYMERS; Subject Term: CALORIMETRY; Subject Term: MICROSCOPY; Author-Supplied Keyword: chemometrics; Author-Supplied Keyword: dissolution profile; Author-Supplied Keyword: film coat curing; Author-Supplied Keyword: multivariate analysis; Author-Supplied Keyword: NIR spectroscopy; Author-Supplied Keyword: prediction; Author-Supplied Keyword: standard error of calibration; Author-Supplied Keyword: standard error of prediction; Author-Supplied Keyword: tablet coating; NAICS/Industry Codes: 325510 Paint and Coating Manufacturing; Number of Pages: 20p; Illustrations: 3 Charts, 18 Graphs; Document Type: Article
L3 - 10.1002/jps.21420
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33468078&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105573122
T1 - Compact and portable digitally controlled device for testing footwear materials: technical note.
AU - Foto JG
Y1 - 2008/09//
N1 - Accession Number: 105573122. Language: English. Entry Date: 20090123. Revision Date: 20151015. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 8410047.
KW - Computer Simulation
KW - Foot Orthoses
KW - Materials Testing -- Equipment and Supplies
KW - Computer Aided Design
KW - Descriptive Statistics
KW - Evaluation Research
KW - Foot
KW - Peripheral Nervous System Diseases -- Rehabilitation
KW - User-Computer Interface
KW - Human
SP - 893
EP - 900
JO - Journal of Rehabilitation Research & Development
JF - Journal of Rehabilitation Research & Development
JA - J REHABIL RES DEV
VL - 45
IS - 6
CY - Baltimore, Maryland
PB - VA Prosthetics Research & Development Center
AB - Little or no practical decision-making data are available to the foot-care provider regarding the selection of orthotic materials used in therapeutic footwear. A device for simulating in-shoe forefoot conditions for the testing of orthosis materials is described. Materials are tested for their effectiveness by evaluating and comparing stress-strain and dynamic compression fatigue characteristics. The device, called the Cyclical Compression Tester (CCT), has been optimized for size, simplicity of construction, and cost. Application of the device ranges from the clinician deciding the useful life of single- and multidensity orthosis materials to the researcher characterizing materials for finite-element analysis modeling. This real-time CCT device and custom user interface combine to make an evaluation tool useful for testing how the pressure distribution of in-shoe materials changes over time in therapeutic footwear for those with peripheral neuropathy at risk for foot injury.
SN - 0748-7711
AD - National Hansen's Disease Programs, Paul W. Brand Biomechanics Laboratory, 1770 Physicians Park Dr, Baton Rouge, LA 70816. jfoto@hrsa.gov.
U2 - PMID: 19009475.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wear, Keith A.
AU - Padilla, Frederic
AU - Laugier, Pascal
T1 - Comparison of the Faran Cylinder Model and the Weak Scattering Model for predicting the frequency dependence of backscatter from human cancellous femur in vitro.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/09//
VL - 124
IS - 3
M3 - Article
SP - 1408
EP - 1410
SN - 00014966
AB - This letter presents the first side-by-side comparison of the Faran Cylinder Model and the Weak Scattering Model for predicting backscatter from human femur. Both models are applied to the same dataset of frequency-dependent backscatter coefficients from 26 human femur cancellous bone samples in vitro. The Faran Cylinder Model predicts a slightly slower rate of increase of backscatter with frequency than the Weak Scattering Model, but both models are in reasonable agreement with the data and with each other, given the uncertainty in the measurements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRONS -- Backscattering
KW - GAMMA rays -- Backscattering
KW - SCATTERING (Physics)
KW - BACKSCATTERING
KW - FEMUR
KW - BONES
N1 - Accession Number: 34428248; Wear, Keith A. 1; Email Address: kaw@fda.hhs.gov Padilla, Frederic 2 Laugier, Pascal 2,3; Affiliation: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993 2: CNRS, UMR 7623, Laboratoire d'Imagerie Paramétrique, F-75006, Paris, France 3: UPMC University of Paris 06, UMR 7623, LIP, F-75005, Paris, France; Source Info: Sep2008, Vol. 124 Issue 3, p1408; Subject Term: ELECTRONS -- Backscattering; Subject Term: GAMMA rays -- Backscattering; Subject Term: SCATTERING (Physics); Subject Term: BACKSCATTERING; Subject Term: FEMUR; Subject Term: BONES; Number of Pages: 3p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1121/1.2956480
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, Christian C.
AU - Marutyan, Karen R.
AU - Holland, Mark R.
AU - Wear, Keith A.
AU - Miller, James G.
T1 - Interference between wave modes may contribute to the apparent negative dispersion observed in cancellous bone.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/09//
VL - 124
IS - 3
M3 - Article
SP - 1781
EP - 1789
SN - 00014966
AB - Previous work has shown that ultrasonic waves propagating through cancellous bone often exhibit a linear-with-frequency attenuation coefficient, but a decrease in phase velocity with frequency (negative dispersion) that is inconsistent with the causality-imposed Kramers–Kronig relations. In the current study, interfering wave modes similar to those observed in bone are shown to potentially contribute to the observed negative dispersion. Biot theory, the modified Biot–Attenborogh model, and experimental results are used to aid in simulating multiple-mode wave propagation through cancellous bone. Simulations entail constructing individual wave modes exhibiting a positive dispersion using plausible velocities and amplitudes, and then summing the individual modes to create mixed-mode output wave forms. Results of the simulations indicate that mixed-mode wave forms can exhibit negative dispersion when analyzed conventionally under the assumption that only one wave is present, even when the individual interfering waves exhibit positive dispersions in accordance with the Kramers–Kronig relations. Furthermore, negative dispersion is observed when little or no visual evidence of interference exists in the time-domain data. Understanding the mechanisms responsible for the observed negative dispersion could aid in determining the true material properties of cancellous bone, as opposed to the apparent properties measured using conventional data analysis techniques. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC waves
KW - SOUND waves
KW - ULTRASONICS
KW - INTERFERENCE (Sound)
KW - BIOT theory (Mechanics)
KW - DATA analysis
N1 - Accession Number: 34428212; Anderson, Christian C. 1 Marutyan, Karen R. 1 Holland, Mark R. 1 Wear, Keith A. 2 Miller, James G. 1; Email Address: james.g.miller@wustl.edu; Affiliation: 1: Department of Physics, Washington University in St. Louis, St. Louis, Missouri 63130 2: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Sep2008, Vol. 124 Issue 3, p1781; Subject Term: ULTRASONIC waves; Subject Term: SOUND waves; Subject Term: ULTRASONICS; Subject Term: INTERFERENCE (Sound); Subject Term: BIOT theory (Mechanics); Subject Term: DATA analysis; Number of Pages: 9p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1121/1.2953309
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34428212&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myers, Matthew R.
AU - Hariharan, Prasanna
AU - Banerjee, Rupak K.
T1 - Direct methods for characterizing high-intensity focused ultrasound transducers using acoustic streaming.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/09//
VL - 124
IS - 3
M3 - Article
SP - 1790
EP - 1802
SN - 00014966
AB - Two techniques are presented for noninvasively determining the intensity field of high-intensity focused ultrasound transducers in a liquid medium. The techniques are based upon the streaming velocity induced in the liquid by the absorbed ultrasound beam. The approaches are similar to an iterative streaming method previously reported, but the present approaches are “direct:” The differential operations of the Navier–Stokes equations are performed directly upon the experimentally measured streaming velocity, rather than through an iterative approach that minimizes the difference between a theoretical estimate of the streaming velocity and the one measured experimentally. As such, the direct methods are much faster than the iterative technique. The price paid for the increase in speed is smaller spatial coverage; the direct techniques are applicable only where accurate streaming velocity is available. Comparisons performed in the range 100–1000 W/cm2 focal intensity showed differences between the direct methods and the iterative streaming technique to be less than 20%. Similar differences were observed in low-power comparisons with hydrophone measurements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSDUCERS
KW - LIQUIDS
KW - NAVIER-Stokes equations
KW - ACOUSTIC streaming
KW - FLUID dynamics
KW - SOUND waves
N1 - Accession Number: 34428213; Myers, Matthew R. 1; Email Address: matthew.myers@fda.hhs.gov Hariharan, Prasanna 1 Banerjee, Rupak K. 1; Affiliation: 1: Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, U. S. FDA, 10903 New Hampshire Avenue, Building 62, Room 2231, Silver Spring, Maryland 20993-0002; Source Info: Sep2008, Vol. 124 Issue 3, p1790; Subject Term: TRANSDUCERS; Subject Term: LIQUIDS; Subject Term: NAVIER-Stokes equations; Subject Term: ACOUSTIC streaming; Subject Term: FLUID dynamics; Subject Term: SOUND waves; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; Number of Pages: 13p; Illustrations: 1 Chart, 12 Graphs; Document Type: Article
L3 - 10.1121/1.2957937
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34428213&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Liu, Yunbo
AU - Maruvada, Subha
AU - King, Randy L.
AU - Herman, Bruce A.
AU - Wear, Keith A.
T1 - Development and characterization of a blood mimicking fluid for high intensity focused ultrasound.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/09//
VL - 124
IS - 3
M3 - Article
SP - 1803
EP - 1810
SN - 00014966
AB - A blood mimicking fluid (BMF) has been developed for the acoustic and thermal characterizations of high intensity focused ultrasound (HIFU) ablation devices. The BMF is based on a degassed and de-ionized water solution dispersed with low density polyethylene microspheres, nylon particles, gellan gum, and glycerol. A broad range of physical parameters, including attenuation coefficient, speed of sound, viscosity, thermal conductivity, and diffusivity, were characterized as a function of temperature (20–70 °C). The nonlinear parameter B/A and backscatter coefficient were also measured at room temperature. Importantly, the attenuation coefficient is linearly proportional to the frequency (2–8 MHz) with a slope of about 0.2 dB cm-1 MHz-1 in the 20–70 °C range as in the case of human blood. Furthermore, sound speed and bloodlike backscattering indicate the usefulness of the BMF for ultrasound flow imaging and ultrasound-guided HIFU applications. Most of the other temperature-dependent physical parameters are also close to the reported values in human blood. These properties make it a unique HIFU research tool for developing standardized exposimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU ablation devices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC imaging
KW - BLOOD
KW - LOW density polyethylene
KW - MICROSPHERES
KW - GLYCERIN
KW - ATTENUATION (Physics)
N1 - Accession Number: 34428211; Liu, Yunbo 1 Maruvada, Subha 1 King, Randy L. 2 Herman, Bruce A. 1 Wear, Keith A. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993 2: Department of Bioengineering, Stanford University, Stanford, California 94305; Source Info: Sep2008, Vol. 124 Issue 3, p1803; Subject Term: ULTRASONIC imaging; Subject Term: BLOOD; Subject Term: LOW density polyethylene; Subject Term: MICROSPHERES; Subject Term: GLYCERIN; Subject Term: ATTENUATION (Physics); NAICS/Industry Codes: 325611 Soap and Other Detergent Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; Number of Pages: 8p; Illustrations: 1 Color Photograph, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1121/1.2956469
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105702827
T1 - Vitamin d deficiency in a nonrandom sample of southeast Alaska Natives.
AU - Frost JT
AU - Hill L
Y1 - 2008/09//
N1 - Accession Number: 105702827. Language: English. Entry Date: 20081205. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 7503061.
KW - Diabetes Mellitus -- Risk Factors -- Alaska
KW - Vitamin D Deficiency -- Epidemiology -- Alaska
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and Over
KW - Alaska
KW - Body Mass Index
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Hematologic Tests
KW - Male
KW - Middle Age
KW - Native Americans
KW - Record Review
KW - Retrospective Design
KW - T-Tests
KW - Human
SP - 1508
EP - 1511
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 108
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - Lieutenant Commander, US Public Health Service
U2 - PMID: 18755324.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nanda, Santosh
AU - Jayan, Geetha
AU - Voulgaropoulou, Frosso
AU - Sierra-Honigmann, Ana Maria
AU - Uhlenhaut, Christine
AU - McWatters, Bernard J.P.
AU - Patel, Amita
AU - Krause, Philip R.
T1 - Universal virus detection by degenerate-oligonucleotide primed polymerase chain reaction of purified viral nucleic acids
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008/09//
VL - 152
IS - 1/2
M3 - Article
SP - 18
EP - 24
SN - 01660934
AB - Summary: This study describes a novel non-specific universal virus detection method that permits molecular detection of viruses in biological materials containing mixtures of cells and viruses. Samples are subjected to nuclease digestion and ultracentrifugation to separate encapsidated viral nucleic acids from cellular nucleic acids. A degenerate oligonucleotide primer PCR (DOP-PCR) that has been optimized for the non-specific amplification of virus sized genomes is then employed. Virus identification is performed by sequencing of cloned DOP-PCR products followed by sequence comparison to sequences published in GenBank. This method was used to detect a variety of DNA viruses (including HSV, VZV, SV40, AAV, and EBV) and RNA viruses (including HTLV-I, HTLV-II, influenza, and poliovirus), which were spiked into cells, constitutively expressed in cell culture, or detected in productively infected cultured cells. This novel approach was compared with a non-specific virus detection method used previously and found to be several logs more sensitive. This type of approach has potential utility in solving virus detection and discovery problems where other methods have failed. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETROVIRUSES
KW - RESPIRATORY infections
KW - POLYMERASE chain reaction
KW - NUCLEIC acids
KW - Capsid preparation
KW - cytopathic effect ( CPE )
KW - degenerate oligo primer-polymerase chain reaction ( DOP-PCR )
KW - DOP-PCR
KW - Non-specific virus detection
KW - representational difference analysis ( RDA )
KW - sequence-independent single primer amplification ( SISPA )
KW - Universal virus detection
KW - Virus discovery
N1 - Accession Number: 33526980; Nanda, Santosh 1 Jayan, Geetha 1 Voulgaropoulou, Frosso 1 Sierra-Honigmann, Ana Maria 1 Uhlenhaut, Christine 1 McWatters, Bernard J.P. 1 Patel, Amita 1 Krause, Philip R.; Email Address: philip.krause@fda.hhs.gov; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, United States; Source Info: Sep2008, Vol. 152 Issue 1/2, p18; Subject Term: RETROVIRUSES; Subject Term: RESPIRATORY infections; Subject Term: POLYMERASE chain reaction; Subject Term: NUCLEIC acids; Author-Supplied Keyword: Capsid preparation; Author-Supplied Keyword: cytopathic effect ( CPE ); Author-Supplied Keyword: degenerate oligo primer-polymerase chain reaction ( DOP-PCR ); Author-Supplied Keyword: DOP-PCR; Author-Supplied Keyword: Non-specific virus detection; Author-Supplied Keyword: representational difference analysis ( RDA ); Author-Supplied Keyword: sequence-independent single primer amplification ( SISPA ); Author-Supplied Keyword: Universal virus detection; Author-Supplied Keyword: Virus discovery; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2008.06.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schachter, E.
AU - Zuskin, Eugenija
AU - Arumugam, Uma
AU - Goswami, Satindra
AU - Castranova, Vincent
AU - Whitmer, Mike
AU - Chiarelli, Angelo
T1 - Pharmacologic Effects of Grain Weevil Extract on Isolated Guinea Pig Tracheal Smooth Muscle.
JO - Lung
JF - Lung
Y1 - 2008/09//
VL - 186
IS - 5
M3 - Article
SP - 317
EP - 321
SN - 03412040
AB - The grain weevil, an insect (pest) that infects grain, is a frequent contaminant of processed wheat, and its presence may contribute to respiratory abnormalities in grain workers. We studied the in vitro effects of an extract of grain weevil (GWE) on airway smooth muscle. Pharmacologic studies included in vitro challenge of guinea pig trachea with GWE, in parallel organ baths, pretreated with mediator-modifying agents or a control solution. Dose-related contractions of nonsensitized guinea pig trachea (GPT) were demonstrated using this extract. Pharmacologic studies were performed by pretreating guinea pig tracheal tissue with drugs known to modulate smooth muscle contraction: atropine, indomethacin, pyrilamine, acivicin, NDGA, BPB, TMB8, captopril, and capsaicin. Atropine, pyrilamine, BPB, and capsaicin significantly reduced the contractile effects of the extract at most of the challenge doses ( p < 0.01 or p < 0.05). Inhibition of GWE-induced contraction by blocking of other mediators was less complete. We suggest that GWE causes dose-related airway smooth muscle constriction of the GPT by nonimmunologic mechanisms involving a variety of airway mediators and possibly cholinergic receptors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Lung is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRANARY weevil
KW - TRACHEA -- Diseases
KW - AIRWAY (Medicine)
KW - SMOOTH muscle
KW - RESPIRATORY organs
KW - PHARMACOLOGY
KW - Airway responses
KW - Grain weevil extract
KW - Isolated guinea pig trachea
N1 - Accession Number: 34406265; Schachter, E. 1; Email Address: neil.schachter@mssm.edu Zuskin, Eugenija 2 Arumugam, Uma 1 Goswami, Satindra 1 Castranova, Vincent 3 Whitmer, Mike 3 Chiarelli, Angelo 1; Affiliation: 1: Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA 2: Andrija Stampar School of Public Health, Zagreb, Croatia 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Sep2008, Vol. 186 Issue 5, p317; Subject Term: GRANARY weevil; Subject Term: TRACHEA -- Diseases; Subject Term: AIRWAY (Medicine); Subject Term: SMOOTH muscle; Subject Term: RESPIRATORY organs; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: Airway responses; Author-Supplied Keyword: Grain weevil extract; Author-Supplied Keyword: Isolated guinea pig trachea; Number of Pages: 5p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1007/s00408-008-9112-8
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Granite, Evan J.
AU - King, William P.
AU - Stanko, Dennis C.
AU - Pennline, Henry W.
T1 - Implications of mercury interactions with band-gap semiconductor oxides.
JO - Main Group Chemistry
JF - Main Group Chemistry
Y1 - 2008/09//
VL - 7
IS - 3
M3 - Article
SP - 227
EP - 237
SN - 10241221
AB - Titanium dioxide is a well-known photooxidation catalyst. It will oxidize mercury in the presence of ultraviolet light from the sun and oxygen and/or moisture to form mercuric oxide. Several companies manufacture self-cleaning windows. These windows have a transparent coating of titanium dioxide. The titanium dioxide is capable of destroying organic contaminants in air in the presence of ultraviolet light from the sun, thereby keeping the windows clean. The commercially available self-cleaning windows were used to sequester mercury from oxygen-nitrogen mixtures. Samples of the self-cleaning glass were placed into specially designed photo-reactors in order to study the removal of elemental mercury from oxygen-nitrogen mixtures resembling air. The possibility of removing mercury from ambient air with a self-cleaning glass apparatus is examined. The intensity of 365-nm ultraviolet light was similar to the natural intensity from sunlight in the Pittsburgh region. Passive removal of mercury from the air may represent an option in lieu of, or in addition to, point source clean-up at combustion facilities. There are several common band-gap semiconductor oxide photocatalysts. Sunlight (both the ultraviolet and visible light components) and band-gap semiconductor particles may have a small impact on the global cycle of mercury in the environment. The potential environmental consequences of mercury interactions with band-gap semiconductor oxides are discussed. Heterogeneous photooxidation might impact the global transport of elemental mercury emanating from flue gases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Main Group Chemistry is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATALYSTS
KW - TITANIUM dioxide
KW - OXIDES
KW - MERCURY
KW - ULTRAVIOLET radiation
KW - band-gap semiconductor oxide
KW - mercury
KW - photocatalyst
KW - photooxidation
KW - titania
N1 - Accession Number: 35809140; Granite, Evan J. 1; Email Address: evan.granite@netl.doe.gov King, William P. 2 Stanko, Dennis C. 1 Pennline, Henry W. 1; Affiliation: 1: United States Department of Energy, National Energy Technology Laboratory, Pittsburgh, USA. 2: National Institute for Occupational Safety and Health, National Personal Protective Laboratory, Pittsburg, PA, USA.; Source Info: Sep2008, Vol. 7 Issue 3, p227; Subject Term: CATALYSTS; Subject Term: TITANIUM dioxide; Subject Term: OXIDES; Subject Term: MERCURY; Subject Term: ULTRAVIOLET radiation; Author-Supplied Keyword: band-gap semiconductor oxide; Author-Supplied Keyword: mercury; Author-Supplied Keyword: photocatalyst; Author-Supplied Keyword: photooxidation; Author-Supplied Keyword: titania; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 11p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1080/10241220802630568
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105649597
T1 - Self-rated mental health and racial/ethnic disparities in mental health service use.
AU - Zuvekas SH
AU - Fleishman JA
Y1 - 2008/09//2008 Sep
N1 - Accession Number: 105649597. Language: English. Entry Date: 20080919. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Mental Component Summary (MCS). NLM UID: 0230027.
KW - Affective Symptoms -- Ethnology
KW - Attitude to Health
KW - Blacks -- Psychosocial Factors
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Hispanics -- Psychosocial Factors
KW - Mental Health Services -- Utilization
KW - Mental Health
KW - Whites -- Psychosocial Factors
KW - Adolescence
KW - Adult
KW - Affective Symptoms -- Epidemiology
KW - Aged
KW - Aged, 80 and Over
KW - Ambulatory Care -- Utilization
KW - Blacks -- Statistics and Numerical Data
KW - Cross Sectional Studies
KW - Female
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Services Research
KW - Health Status
KW - Hispanics -- Statistics and Numerical Data
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Psychotherapy -- Statistics and Numerical Data
KW - Psychotropic Drugs -- Therapeutic Use
KW - Questionnaires
KW - United States
KW - Utilization Review -- Statistics and Numerical Data
KW - Whites -- Statistics and Numerical Data
KW - Human
SP - 915
EP - 923
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 46
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: Studies of health service use for emotional problems show that the majority of those with disorders do not seek professional help. In addition, mental health service use is lower among members of minority communities, compared with non-Hispanic whites. OBJECTIVE: To examine the role of self-reported mental health as an indicator of awareness of mental conditions and as an influence in the process of seeking mental health care. RESEARCH DESIGN: We conducted cross-sectional analyses of nationally representative data from the Medical Expenditure Panel Survey (MEPS) for 2000-2004. MEASURES: In-person interviews obtained data on self-rated mental health (SRMH), ambulatory mental health visits, and purchase of prescription medications to treat mental conditions. Respondents completed the SF-12 health status survey; analyses included the SF-12 mental component summary (MCS) as a measure of emotional symptoms. Analyses included only those who provided self-reports of MCS and SRMH. RESULTS: SRMH was related to any ambulatory visit and any medication purchase for mental health treatment, controlling for MCS, and other sociodemographic and clinical variables. The association between SRMH and service use was weaker for black and Hispanic respondents than for whites. In addition, the magnitude of the association between SRMH and MCS was weaker for black and Hispanic respondents than for whites. CONCLUSIONS: Racial/ethnic differences in service use may arise in part from different propensities to interpret emotional symptoms as reflecting one's mental health and then to seek professional intervention for emotional problems. SRMH may be useful as an indicator of the extent to which people acknowledge the existence of emotional problems.
SN - 0025-7079
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA.
U2 - PMID: 18725845.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105649597&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 115807248
T1 - Mother's menopausal age is associated with her daughter's early follicular phase urinary follicle-stimulating hormone level.
AU - Steiner, Anne Z.
AU - Baird, Donna D.
AU - Kesner, James S.
Y1 - 2008/09//Sep/Oct2008
N1 - Accession Number: 115807248. Language: English. Entry Date: 20161116. Revision Date: 20161116. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Maternal Confidence Questionnaire (MCQ) (Parker and Zahr); Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: 5K12 HD050113-02/HD/NICHD NIH HHS/United States. NLM UID: 9433353.
KW - Menopause
KW - Ovary -- Physiology
KW - Follicular Phase -- Physiology
KW - Follicle-Stimulating Hormone -- Urine
KW - Mothers
KW - Aging
KW - Ovarian Function Tests
KW - Ovulation Prediction
KW - Middle Age
KW - Age Factors
KW - Regression
KW - Female
KW - Human
KW - Adult
KW - Validation Studies
KW - Comparative Studies
KW - Evaluation Research
KW - Multicenter Studies
KW - Center for Epidemiological Studies Depression Scale
KW - Questionnaires
SP - 940
EP - 944
JO - Menopause (10723714)
JF - Menopause (10723714)
JA - MENOPAUSE
VL - 15
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: Early follicular phase follicle-stimulating hormone (FSH), a marker of ovarian reserve, has been used to predict time to menopause. A mother's age at menopause is related to her daughter's age at menopause, possibly because of genetic factors. In this study we sought to determine the relationship between maternal age at menopause and early follicular phase FSH of premenopausal daughters.Design: The Uterine Fibroid Study enrolled women randomly selected from a prepaid health plan, collected questionnaire data, and obtained early follicular phase urine samples for a subset of participants. For this secondary analysis, premenopausal women between the ages of 35 and 46 years, who provided a urine sample on cycle day 2, 3, 4, or 5 and their mother's age at natural menopause (n = 182) were selected from the original cohort. Initially bivariate analysis and subsequently regression modeling were performed to assess the independent relationship between maternal age at menopause and urinary creatinine-corrected FSH.Results: Unadjusted analyses and those adjusting for age (mean +/- SD, 40.5 +/- 3.2 y), smoking status (16% current smokers), and body mass index (26.8 +/- 6.9 kg/m) showed a significant association between maternal age at menopause and daughter's urinary FSH level (P < 0.04). Women whose mothers experienced earlier menopause had higher urinary FSH levels.Conclusions: The significantly increased FSH values among women whose mothers experienced early menopause is consistent with previously reported associations between mother's and daughter's age of menopause. FSH, a marker of ovarian reserve, is influenced by both genetic and environmental factors. Future epidemiologic studies on FSH should include collection of information on maternal age at menopause.
SN - 1072-3714
AD - From the 1 Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC; 2 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC; and 3 Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH.
U2 - PMID: 18779679.
DO - 10.1097/gme.0b013e31816429e5
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Huizhong Chen
AU - Haiyan Xu
AU - Ohgew Kweon
AU - Siwel Chen
AU - Cerniglia, Carl E.
T1 - Functional role of Trp-105 of Enterococcus faecalis azoreductase (AzoA) as resolved by structural and mutational analysis.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2008/09//
VL - 154
IS - 9
M3 - Article
SP - 2659
EP - 2667
SN - 13500872
AB - The article reports on the functional role of Trp-105 for the FMN binding in Enterocuccus faecalis azoreductase (AzoA), an active enzyme with a broad spectrum of substrate specificity. Study reveals that Trp residue at position 105 of AzoA is the most significant contributor to the binding of FMN to the enzyme based on silico analysis of the amino acid residues. Furthermore, to determine the role of this amino acid residue in FMN binding, a site-directed mutagenesis analysis of Trp-105 was further performed. Moreover, an insight into the catalytic properties of AzoA in FMN stabilization and enzyme activity was provided by the study.
KW - Mutation (Biology)
KW - Plant growing media
KW - Mutagenicity testing
KW - Enzymes -- Analysis
KW - Catalysts
KW - Immunospecificity
KW - Amino acids -- Analysis
KW - Mutagenesis
KW - Microbiology experiments
N1 - Accession Number: 34678546; Huizhong Chen 1; Email Address: huizhong.chen@fda.hhs.gov; Haiyan Xu 1; Ohgew Kweon 1; Siwel Chen 1; Cerniglia, Carl E. 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079-9502, USA; Issue Info: Sep2008, Vol. 154 Issue 9, p2659; Thesaurus Term: Mutation (Biology); Thesaurus Term: Plant growing media; Thesaurus Term: Mutagenicity testing; Subject Term: Enzymes -- Analysis; Subject Term: Catalysts; Subject Term: Immunospecificity; Subject Term: Amino acids -- Analysis; Subject Term: Mutagenesis; Subject Term: Microbiology experiments; Number of Pages: 9p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1099/mic.0.2008/019877-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34678546&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bronzan, Rachel N.
AU - McMorrow, Meredith L.
AU - Kachur, S. Patrick
T1 - Diagnosis of Malaria.
JO - Molecular Diagnosis & Therapy
JF - Molecular Diagnosis & Therapy
Y1 - 2008/09//
VL - 12
IS - 5
M3 - Article
SP - 299
EP - 306
SN - 11771062
AB - Malaria is a leading cause of morbidity and mortality worldwide. Prompt diagnosis and treatment are critical factors in reducing morbidity and mortality, as delayed treatment of malaria increases the risk of death. Microscopy has long been the standard of malaria diagnosis, but newer diagnostic tests now offer advantages in certain settings. Malaria diagnosis is complicated by the fact that acquired immunity to malaria can result in asymptomatic infections. In a symptomatic (febrile) patient, no existing malaria diagnostic test can distinguish malarial illness from parasitemia with concomitant fever of another cause. In this review we discuss the available malaria diagnostic tests, appropriate applications for each, and the challenges of malaria diagnosis in both endemic and non-endemic settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Diagnosis & Therapy is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALARIA -- Diagnosis
KW - DISEASES
KW - MORTALITY
KW - DEATH
KW - MEDICAL microscopy
KW - FEVER
N1 - Accession Number: 38707597; Bronzan, Rachel N. 1; Email Address: RBronzan@cdc.gov McMorrow, Meredith L. 1 Kachur, S. Patrick 1; Affiliation: 1: United States Public Health Service, Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; Source Info: Sep2008, Vol. 12 Issue 5, p299; Subject Term: MALARIA -- Diagnosis; Subject Term: DISEASES; Subject Term: MORTALITY; Subject Term: DEATH; Subject Term: MEDICAL microscopy; Subject Term: FEVER; Number of Pages: 8p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen, Cory
AU - Paraskevakou, Georgia
AU - Iankov, Ianko
AU - Giannini, Caterina
AU - Schroeder, Mark
AU - Sarkaria, Jann
AU - Puri, Raj K
AU - Russell, Stephen J
AU - Galanis, Evanthia
T1 - Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity.
JO - Molecular Therapy
JF - Molecular Therapy
Y1 - 2008/09//
VL - 16
IS - 9
M3 - Article
SP - 1556
EP - 1564
SN - 15250016
AB - The majority of glioblastoma multiforme (GBM) tumors (80%) overexpress interleukin-13 receptor α2 (IL-13Rα2), but there is no expression of IL-13Rα2 in normal brain. Vaccine strains of measles virus have significant antitumor activity against gliomas. We tested the hypothesis that measles virus entry could be retargeted via the IL-13Rα2. MV-GFP-HAA-IL-13 was generated from the Edmonston-NSe vaccine strain, by displaying human IL-13 at the C-terminus of the H protein, and introducing CD46 and signaling lymphocyte activation molecule (SLAM)-ablating mutations in H. The IL-13 retargeted virus showed significant cytopathic effect (CPE) against IL-13Rα2 overexpressing glioma lines, and lack of CPE/viral replication in normal human astrocytes and normal human fibroblasts not expressing IL-13Rα2. In vivo treatment of orthotopically implanted GBM12 xenografts demonstrated significant prolongation of survival in mice treated with the retargeted strain (P < 0.0001), and comparable activity between the IL-13R retargeted strain and MV-GFP (P = 0.6377). In contrast to MV-GFP-treated mice, administration of the retargeted strain in the central nervous system of measles replication-permissive Ifnarko CD46 Ge mice resulted in lack of neurotoxicity. Strains of measles virus retargeted against the glioma-specific IL-13Rα2 receptor have comparable therapeutic efficacy, and improved specificity as compared with the unmodified measles virus strain MV-GFP in vitro and in vivo.Molecular Therapy (2008) 16 9, 1556–1564 doi:10.1038/mt.2008.152 [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Therapy is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLIOBLASTOMA multiforme
KW - TUMORS
KW - INTERLEUKIN-13
KW - GLIOMAS
KW - ASTROCYTES
KW - FIBROBLASTS
N1 - Accession Number: 33998818; Allen, Cory 1 Paraskevakou, Georgia 1 Iankov, Ianko 1 Giannini, Caterina 2 Schroeder, Mark 3 Sarkaria, Jann 3 Puri, Raj K 4 Russell, Stephen J 1 Galanis, Evanthia 5; Email Address: galanis.evanthia@mayo.edu; Affiliation: 1: Molecular Medicine Department, Mayo Clinic College Of Medicine, Rochester, Minnesota, USA 2: Division of Anatomic Pathology, Mayo Clinic College Of Medicine, Rochester, Minnesota, USA 3: Radiation Oncology Research, Mayo Clinic College Of Medicine, Rochester, Minnesota, USA 4: US Food and Drug Administration, Rockville, Maryland, USA 5: Department of Oncology, Mayo Clinic College Of Medicine, Rochester, Minnesota, USA; Source Info: Sep2008, Vol. 16 Issue 9, p1556; Subject Term: GLIOBLASTOMA multiforme; Subject Term: TUMORS; Subject Term: INTERLEUKIN-13; Subject Term: GLIOMAS; Subject Term: ASTROCYTES; Subject Term: FIBROBLASTS; Number of Pages: 9p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1038/mt.2008.152
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33998818&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parsons, Barbara L.
T1 - Many different tumor types have polyclonal tumor origin: Evidence and implications
JO - Mutation Research/Reviews in Mutation Research
JF - Mutation Research/Reviews in Mutation Research
Y1 - 2008/09//
VL - 659
IS - 3
M3 - Article
SP - 232
EP - 247
SN - 13835742
AB - Abstract: Few ideas have gained such strong acceptance in the scientific community as the monoclonal origin of tumors; the idea that tumors start with a single mutated cell (or a single clone of cells) that go on to accumulate additional mutations as a tumor develops. The certainty with which this concept is held by the scientific community reflects the length of time it has been unchallenged and the experimental difficulty in obtaining direct evidence to the contrary. Yet, recent findings regarding X chromosome inactivation patch size indicate that the X-linked marker data previously interpreted as evidence of monoclonal tumor origin is actually more consistent with polyclonal tumor origin, a situation where two or more cells or clones of cells interact to initiate a tumor. Although most tumors show homotypy for X-linked markers (as expected given the bias conferred by X chromosome inactivation patch size), the literature contains numerous examples of tumors with X-linked marker heterotypy, examples of which encompass 24 different tumor types. Chimeric models have yielded direct unequivocal demonstrations of polyclonality in rodent and human tumors. Also, mutational data are consistent with polyclonal tumor origin. Methods that analyze levels of tumor-associated oncogene and tumor suppressor gene mutations demonstrate that initiated cells are much more common in normal tissues than previously realized. Also, while tumors have higher levels of mutation than normal tissues, oncogenic mutations frequently are present as subpopulations within tumors, rather than as the pure mutant populations expected to develop from a single initiated cell. Understanding the mutational basis of tumor etiology has important practical significance for assessing cancer risk, as well as in modeling and treating cancer. Therefore, the scientific community needs to re-examine this issue and consider the implications of polyclonal origin for, perhaps, a majority of tumors, encompassing many different tumor types. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Reviews in Mutation Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Dehydrogenases
KW - Cell nuclei
KW - Electrophoresis
KW - aberrant crypt foci ( ACF )
KW - adenomatous polyposis coli ( APC )
KW - allele-specific competitive blocker polymerase chain reaction ( ACB-PCR )
KW - chronic myelocytic leukemia ( CML )
KW - denaturing gradient gel electrophoresis ( DGGE )
KW - Familial Adenomatous Polyposis ( FAP )
KW - glucose-6-phosphate dehydrogenase ( G-6-PD )
KW - human androgen receptor gene ( HUMARA )
KW - hypoxanthine-guanine phosophoribosyltransferase ( HPRT )
KW - immunoglobulin ( Ig )
KW - Monoclonal
KW - mutant fraction ( MF )
KW - restriction fragment length polymorphism ( RFLP )
KW - Somatic mutation
KW - Tumor clonality
KW - Tumor development
KW - Tumor etiology
KW - X chromosome inactivation
N1 - Accession Number: 34093571; Parsons, Barbara L. 1; Email Address: barbara.parsons@fda.hhs.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, HFT-120, 3900 NCTR Road, USFDA, Jefferson, AR 72079, United States; Issue Info: Sep2008, Vol. 659 Issue 3, p232; Thesaurus Term: Mutation (Biology); Subject Term: Dehydrogenases; Subject Term: Cell nuclei; Subject Term: Electrophoresis; Author-Supplied Keyword: aberrant crypt foci ( ACF ); Author-Supplied Keyword: adenomatous polyposis coli ( APC ); Author-Supplied Keyword: allele-specific competitive blocker polymerase chain reaction ( ACB-PCR ); Author-Supplied Keyword: chronic myelocytic leukemia ( CML ); Author-Supplied Keyword: denaturing gradient gel electrophoresis ( DGGE ); Author-Supplied Keyword: Familial Adenomatous Polyposis ( FAP ); Author-Supplied Keyword: glucose-6-phosphate dehydrogenase ( G-6-PD ); Author-Supplied Keyword: human androgen receptor gene ( HUMARA ); Author-Supplied Keyword: hypoxanthine-guanine phosophoribosyltransferase ( HPRT ); Author-Supplied Keyword: immunoglobulin ( Ig ); Author-Supplied Keyword: Monoclonal; Author-Supplied Keyword: mutant fraction ( MF ); Author-Supplied Keyword: restriction fragment length polymorphism ( RFLP ); Author-Supplied Keyword: Somatic mutation; Author-Supplied Keyword: Tumor clonality; Author-Supplied Keyword: Tumor development; Author-Supplied Keyword: Tumor etiology; Author-Supplied Keyword: X chromosome inactivation; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.mrrev.2008.05.004
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter, Dale
AU - Sriram, Krishnan
AU - Wolfarth, Michael
AU - Jefferson, Amy
AU - Schwegler-Berry, Diane
AU - Andrew, Michael E.
AU - Castranova, Vincent
T1 - A biocompatible medium for nanoparticle dispersion.
JO - Nanotoxicology
JF - Nanotoxicology
Y1 - 2008/09//
VL - 2
IS - 3
M3 - Article
SP - 144
EP - 154
SN - 17435390
AB - Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a 'lung fluid mimic'. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nanotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRONCHOALVEOLAR lavage
KW - NANOPARTICLES
KW - BIOCOMPATIBILITY
KW - LUNGS -- Physiology
KW - ELECTRON microscopy -- Research
KW - TITANIUM dioxide
KW - Nanoparticles
KW - nanotoxicology
KW - nanotubes
N1 - Accession Number: 33716712; Porter, Dale 1,2; Email Address: dporter@cdc.gov Sriram, Krishnan 1 Wolfarth, Michael 1 Jefferson, Amy 1 Schwegler-Berry, Diane 1 Andrew, Michael E. 1 Castranova, Vincent 1,2; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, USA 2: West Virginia University School of Medicine, Department of Physiology and Pharmacology, Morgantown, USA; Source Info: Sep2008, Vol. 2 Issue 3, p144; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: NANOPARTICLES; Subject Term: BIOCOMPATIBILITY; Subject Term: LUNGS -- Physiology; Subject Term: ELECTRON microscopy -- Research; Subject Term: TITANIUM dioxide; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: nanotoxicology; Author-Supplied Keyword: nanotubes; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 11p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1080/17435390802318349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33716712&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pacurari, Maricica
AU - Yin, Xue J.
AU - Ding, Min
AU - Leonard, Steve S.
AU - Schwegler-Berry, Diana
AU - Ducatman, Barbara S.
AU - Chirila, Madalina
AU - Endo, Morinobu
AU - Castranova, Vincent
AU - Vallyathan, Val
T1 - Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells.
JO - Nanotoxicology
JF - Nanotoxicology
Y1 - 2008/09//
VL - 2
IS - 3
M3 - Article
SP - 155
EP - 170
SN - 17435390
AB - Carbon nanotubes are new tools in industry and medicine with their potential applications in many uses. Multiwall carbon nanotubes (MWCNT) with their morphologic similarity to asbestos and wide commercial and biomedical applications necessitate these investigations. The present study investigated the biological reactivity of MWCNT in normal (NM) and malignant (MM) mesothelial cells. MWCNT containing low iron content generated only negligible amounts of reactive oxygen species with both cells. Exposure of both cell types to MWCNT caused cell death, cytotoxicity, DNA damage and apoptosis, which were greater in MM cells. Exposure of both cells to MWCNT caused a parallel activation of two important transcription factors, phosphorylation of H2AX, and PARP activation which were greater in NM cells. Phosphorylation of ERK1/2 and p38 was greater in MM cells than in NM cells. These findings demonstrate that MWCNT are biologically potent activators of molecular events in NM cells associated with mesothelioma development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nanotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON nanotubes
KW - ASBESTOS
KW - RESEARCH
KW - REACTIVITY (Chemistry)
KW - APOPTOSIS
KW - DNA damage
KW - PHOSPHORYLATION
KW - Cytotoxicity
KW - DNA damage
KW - mesothelial cells
KW - multi wall carbon nanotubes
KW - reactive oxygen species
N1 - Accession Number: 33716711; Pacurari, Maricica 1 Yin, Xue J. 2 Ding, Min 1 Leonard, Steve S. 1 Schwegler-Berry, Diana 1 Ducatman, Barbara S. 2 Chirila, Madalina 1 Endo, Morinobu 3 Castranova, Vincent 1 Vallyathan, Val 1; Email Address: vav1@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Department of Pathology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA 3: Faculty of Engineering, Shinshu University, Wakasato, Nagano-shi, Japan; Source Info: Sep2008, Vol. 2 Issue 3, p155; Subject Term: CARBON nanotubes; Subject Term: ASBESTOS; Subject Term: RESEARCH; Subject Term: REACTIVITY (Chemistry); Subject Term: APOPTOSIS; Subject Term: DNA damage; Subject Term: PHOSPHORYLATION; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: mesothelial cells; Author-Supplied Keyword: multi wall carbon nanotubes; Author-Supplied Keyword: reactive oxygen species; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 16p; Illustrations: 4 Black and White Photographs, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1080/17435390802318356
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lanthier, Michael
AU - Behrman, Rachel
AU - Nardinelli, Clark
T1 - Economic issues with follow-on protein products.
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
Y1 - 2008/09//
VL - 7
IS - 9
M3 - review
SP - 733
EP - 737
PB - Nature Publishing Group
SN - 14741776
AB - The economic effects of the possible introduction of 'follow-on' protein products have been the subject of recent debate. Here, we aim to explore the economic issues surrounding this debate using three measures: total sales, product complexity and patent expiry. Our analysis shows that the sales of therapeutic protein products are concentrated in a relatively small number of branded products, which may be the most attractive targets for follow-on development. For the years 2013-2015, we estimate that products representing US$20 billion in annual sales--approximately half of all sales in 2006--can be expected to lose patent protection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Reviews Drug Discovery is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN products industry
KW - PRODUCT safety
KW - PATENTS
KW - ECONOMIC development
KW - PROTEINS
KW - PHARMACEUTICAL research
KW - BIOTECHNOLOGY
KW - BUSINESS
KW - DRUG approval
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 34094649; Lanthier, Michael 1; Email Address: michael.lanthier@fda.hhs.gov Behrman, Rachel 1 Nardinelli, Clark 1; Affiliation: 1: US Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA; Source Info: Sep2008, Vol. 7 Issue 9, p733; Subject Term: PROTEIN products industry; Subject Term: PRODUCT safety; Subject Term: PATENTS; Subject Term: ECONOMIC development; Subject Term: PROTEINS; Subject Term: PHARMACEUTICAL research; Subject Term: BIOTECHNOLOGY; Subject Term: BUSINESS; Subject Term: DRUG approval; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541110 Offices of Lawyers; NAICS/Industry Codes: 541199 All Other Legal Services; Number of Pages: 5p; Illustrations: 2 Charts, 3 Graphs; Document Type: review
L3 - 10.1038/nrd2636
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun Shim
AU - Se Lee
AU - Kab Chae
AU - Chuel Kim
AU - Dae Hwang
AU - Byoung Kim
AU - Seung Jee
AU - Su Lee
AU - Ji Sin
AU - Chang Bae
AU - Byoung Lee
AU - Hyung Lee
AU - Yong Kim
T1 - Nicotine Leads to Improvements in Behavioral Impairment and an Increase in the Nicotine Acetylcholine Receptor in Transgenic Mice.
JO - Neurochemical Research
JF - Neurochemical Research
Y1 - 2008/09//
VL - 33
IS - 9
M3 - Article
SP - 1783
EP - 1788
SN - 03643190
AB - Abstract Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In order to clarify this issue, 12-month-old transgenic mice, expressing neuron-specific enolase (NSE)-controlled APPsw, were treated with low, middle, and high doses of nicotine for 6 months. Herein, we have concluded that the nicotine-treated groups evidenced improvements in behavior and increases in the nicotine acetylcholine receptor, nAchRα7. These findings provide experimental evidence that nicotine effects an improvement in impaired memory, and that this improvement is associated with an increase in nAchRα7. Thus, nicotine may prove a good preventative or therapeutic modality for AD patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Neurochemical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NICOTINE
KW - CHOLINERGIC receptors
KW - TRANSGENIC mice
KW - CIGARETTE smoke
KW - ALZHEIMER'S patients
KW - ALZHEIMER'S disease -- Treatment
KW - MICE as laboratory animals
KW - ENOLASE
N1 - Accession Number: 33395626; Sun Shim 1 Se Lee 1 Kab Chae 1 Chuel Kim 1 Dae Hwang 1 Byoung Kim 1 Seung Jee 1 Su Lee 1 Ji Sin 1 Chang Bae 1 Byoung Lee 1 Hyung Lee 2 Yong Kim 1; Affiliation: 1: Korea Food and Drug Administration Team of Laboratory Animal Resources, National Institute of Toxicological Research 194 Tongilro Eunpyung-ku Seoul 122-704 Republic of Korea 2: KonKuk University Department of Biological Science Seoul 143-701 Republic of Korea; Source Info: Sep2008, Vol. 33 Issue 9, p1783; Subject Term: NICOTINE; Subject Term: CHOLINERGIC receptors; Subject Term: TRANSGENIC mice; Subject Term: CIGARETTE smoke; Subject Term: ALZHEIMER'S patients; Subject Term: ALZHEIMER'S disease -- Treatment; Subject Term: MICE as laboratory animals; Subject Term: ENOLASE; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105652470
T1 - Outbreak case reports.
AU - Choi D
AU - Simmons G
AU - David S
AU - Holmes J
AU - McLean R
AU - Poore M
Y1 - 2008/09//
N1 - Accession Number: 105652470. Language: English. Entry Date: 20080926. Revision Date: 20151015. Publication Type: Journal Article; tables/charts. Journal Subset: Australia & New Zealand; Biomedical; Public Health. Special Interest: Public Health. NLM UID: 101213519.
KW - Disease Outbreaks -- Trends -- New Zealand
KW - Caliciviridae Infections -- Epidemiology
KW - Fish
KW - Food Poisoning -- Epidemiology
KW - Food Services
KW - Gastroenteritis -- Epidemiology
KW - Hepatitis A -- Epidemiology
KW - New Zealand
SP - 6
EP - 7
JO - New Zealand Public Health Surveillance Report
JF - New Zealand Public Health Surveillance Report
JA - NZ PUBLIC HEALTH SURVEILLANCE REP
VL - 6
IS - 3
PB - Institute of Environmental Science & Research Limited
SN - 1176-2888
AD - Technical Officer, Auckland Regional Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Iyer, Anand Krishnan V.
AU - Azad, Neelam
AU - Wang, Liying
AU - Rojanasakul, Yon
T1 - Role of S-nitrosylation in apoptosis resistance and carcinogenesis
JO - Nitric Oxide
JF - Nitric Oxide
Y1 - 2008/09//
VL - 19
IS - 2
M3 - Article
SP - 146
EP - 151
SN - 10898603
AB - Abstract: Nitric oxide (NO) has been widely recognized as a positive regulator of tumorigenesis and cancer progression through its ability to regulate important proteins in various signal transduction pathways. S-Nitrosylation, or covalent attachment of NO to protein sulphydryl groups, has gained prominence as an important mechanism by which NO modulates physiologic and pathologic cellular responses. In this article, we discuss S-nitrosylation of two key apoptosis-regulatory proteins of the intrinsic and extrinsic death pathways, namely B-cell lymphoma-2 (Bcl-2) and FLICE-inhibitory protein (FLIP). These proteins have been shown to be upregulated in a variety of tumors and have been implicated with cancer chemoresistance through dysregulation of apoptosis. S-Nitrosylation of these proteins precludes their ubiquitination and subsequent degradation by the proteasome, thus accentuating their anti-apoptotic effect which is critical in the context of tumorigenic potential and cancer progression. We propose that such post-translational modifications of proteins by NO may be a general mechanism that tumor cells exploit to tilt the scales towards survival and proliferation by evading cell death. [Copyright &y& Elsevier]
AB - Copyright of Nitric Oxide is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL death
KW - APOPTOSIS
KW - BIOMOLECULES
KW - CANCER cells
KW - Apoptosis
KW - Bcl-2
KW - FLIP
KW - Nitric oxide
KW - S-Nitrosylation
KW - Ubiquitination
N1 - Accession Number: 33347134; Iyer, Anand Krishnan V. 1 Azad, Neelam 1 Wang, Liying 2 Rojanasakul, Yon 1; Email Address: yrojan@hsc.wvu.edu; Affiliation: 1: Department of Pharmaceutical Sciences, West Virginia University, P.O. Box 9530, Morgantown, WV 26506, USA 2: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Sep2008, Vol. 19 Issue 2, p146; Subject Term: CELL death; Subject Term: APOPTOSIS; Subject Term: BIOMOLECULES; Subject Term: CANCER cells; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Bcl-2; Author-Supplied Keyword: FLIP; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: S-Nitrosylation; Author-Supplied Keyword: Ubiquitination; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.niox.2008.04.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dement, J. M.
AU - Kuempel, E. D.
AU - Zumwalde, A. D.
AU - Smith, A. J.
AU - Stayner, L. I.
AU - Loomis, D.
T1 - Development of a fibre size-specific job-exposure matrix for airborne asbestos fibres.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2008/09//
VL - 65
IS - 9
M3 - Article
SP - 605
EP - 612
SN - 13510711
AB - Objective: To develop a method for estimating fibre size-specific exposures to airborne asbestos dust for use in epidemiological investigations of exposure-response relations. Methods: Archived membrane filter samples collected at a Charleston, South Carolina asbestos textile plant during 1964-8 were analysed by transmission electron microscopy (TEM) to determine the bivariate diameter/length distribution of airborne fibres by plant operation. The protocol used for these analyses was based on the direct transfer method published by the International Standards Organization (ISO), modified to enhance fibre size determinations, especially for long fibres. Procedures to adjust standard phase contrast microscopy (PCM) fibre concentration measures using the TEM data in a job- exposure matrix (JEM) were developed in order to estimate fibre size-specific exposures. Results: A total of 84 airborne dust samples were used to measure diameter and length for over 18000 fibres or fibre bundles. Consistent with previous studies, a small proportion of airborne fibres were longer than >5 μm in length, but the proportion varied considerably by plant operation (range 6.9% to 20.8%). The bivariate diameter/length distribution of airborne fibres was expressed as the proportion of fibres in 20 size-specific cells and this distribution demonstrated a relatively high degree of variability by plant operation. PCM adjustment factors also varied substantially across plant operations. Conclusions: These data provide new information concerning the airborne fibre characteristics for a previously studied textile facility. The TEM data demonstrate that the vast majority of airborne fibres inhaled by the workers were shorter than 5 μm in length, and thus not included in the PCM-based fibre counts. The TEM data were used to develop a new fibre size-specific JEM for use in an updated cohort mortality study to investigate the role of fibre dimension in the development of asbestos-related lung diseases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestos
KW - Threshold limit values (Industrial toxicology)
KW - Fibers
KW - Electron microscopy
KW - Lung diseases
KW - Textile factories
KW - Cells
KW - South Carolina
KW - International Organization for Standardization
N1 - Accession Number: 34317327; Dement, J. M. 1; Email Address: John.Dement@Duke.edu; Kuempel, E. D. 2; Zumwalde, A. D. 2; Smith, A. J. 2; Stayner, L. I. 3; Loomis, D. 4; Affiliations: 1: Division of Occupational and Environmental Medicine, Department of Community & Family Medicine, Duke University Medical Center, Durham, NC, USA; 2: National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, OH, USA; 3: Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois, Chicago, IL, USA; 4: Environmental and Occupational Health, School of Public Health, University of Nevada, Reno, NV, USA; Issue Info: Sep2008, Vol. 65 Issue 9, p605; Thesaurus Term: Asbestos; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Fibers; Subject Term: Electron microscopy; Subject Term: Lung diseases; Subject Term: Textile factories; Subject Term: Cells; Subject: South Carolina ; Company/Entity: International Organization for Standardization; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 313220 Narrow Fabric Mills and Schiffli Machine Embroidery; NAICS/Industry Codes: 313310 Textile and Fabric Finishing Mills; NAICS/Industry Codes: 314999 All Other Miscellaneous Textile Product Mills; NAICS/Industry Codes: 314990 All other textile product mills; NAICS/Industry Codes: 313320 Fabric Coating Mills; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 236210 Industrial Building Construction; Number of Pages: 8p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1136/oem.2007.033712
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stayner, L.
AU - Kuempel, E.
AU - Gilbert, S.
AU - Hein, M.
AU - Dement, J.
T1 - An epidemiological study of the role of chrysotile asbestos fibre dimensions in determining respiratory disease risk in exposed workers.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2008/09//
VL - 65
IS - 9
M3 - Article
SP - 613
EP - 619
SN - 13510711
AB - Background: Evidence from toxicological studies indicates that the risk of respiratory diseases varies with asbestos fibre length and width. However, there is a total lack of epidemiological evidence concerning this question. Methods: Data were obtained from a cohort mortality study of 3072 workers from an asbestos textile plant which was recently updated for vital status through 2001. A previously developed job exposure matrix based on phase contrast microscopy (PCM) was modified to provide fibre size-specific exposure estimates using data from a re-analysis of samples by transmission electron microscopy (TEM). Cox proportional hazards models were fit using alternative exposure metrics for single and multiple combinations of fibre length and diameter. Results: TEM-based cumulative exposure estimates were found to provide stronger predictions of asbestosis and lung cancer mortality than PCM-based estimates. Cumulative exposures based on individual fibre size-specific categories were all found to be highly statistically significant predictors of lung cancer and asbestosis. Both lung cancer and asbestosis were most strongly associated with exposure to thin fibres (<0.25 μm). Longer (>10 μm) fibres were found to be the strongest predictors of lung cancer, but an inconsistent pattern with fibre length was observed for asbestosis. Cumulative exposures were highly correlated across all fibre size categories in this cohort (0.28-0.99, p values <0.001), which complicates the interpretation of the study findings. Conclusions: Asbestos fibre dimension appears to be an important determinant of respiratory disease risk. Current PCM-based methods may underestimate asbestos exposures to the thinnest fibres, which were the strongest predictor of lung cancer or asbestosis mortality in this study. Additional studies are needed of other asbestos cohorts to further elucidate the role of fibre dimension and type. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestos
KW - Threshold limit values (Industrial toxicology)
KW - Respiratory diseases
KW - Cancer -- Mortality
KW - Electron microscopy
KW - Fibers
KW - Mortality
KW - Lungs -- Cancer
KW - Cohort analysis
N1 - Accession Number: 34317328; Stayner, L. 1; Email Address: Istayner@uic.edu; Kuempel, E. 2; Gilbert, S. 2; Hein, M. 2; Dement, J. 3; Affiliations: 1: Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois, Chicago, Illinois, USA; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 3: Division of Occupational & Environmental Medicine, Department of Community & Family Medicine, Duke University Medical Center, Durham, North Carolina, USA; Issue Info: Sep2008, Vol. 65 Issue 9, p613; Thesaurus Term: Asbestos; Thesaurus Term: Threshold limit values (Industrial toxicology); Subject Term: Respiratory diseases; Subject Term: Cancer -- Mortality; Subject Term: Electron microscopy; Subject Term: Fibers; Subject Term: Mortality; Subject Term: Lungs -- Cancer; Subject Term: Cohort analysis; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 7p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1136/oem.2007.035584
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105709646
T1 - FDA report: eculizamab (Solaris®) for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
AU - Dmytrijuk A
AU - Robie-Suh K
AU - Cohen MH
AU - Rieves D
AU - Weiss K
AU - Pazdur R
Y1 - 2008/09//
N1 - Accession Number: 105709646. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antibodies, Monoclonal -- Therapeutic Use
KW - Antineoplastic Agents -- Therapeutic Use
KW - Myelodysplastic Syndromes -- Drug Therapy
KW - Antibodies, Monoclonal -- Adverse Effects
KW - Clinical Trials
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Treatment Outcomes
SP - 993
EP - 1000
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 9
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On March 16, 2007, eculizumab (Soliris®; Alexion Pharmaceuticals, Inc. Cheshire, CT), a humanized monoclonal antibody that binds to the human C5 complement protein, received accelerated approval by the U.S. Food and Drug Administration for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis. Eculizumab was studied in a randomized, double-blind, placebo-controlled clinical trial in 87 RBC transfusion-dependent adult PNH patients and in a supportive single-arm study in 96 patients. The eculizumab dose was 600 mg as a 35-minute i.v. infusion administered weekly for the first 4 weeks followed by 900 mg (week 5) then 900 mg every 14 days thereafter. Hemoglobin stabilized in 21 of 43 (48.8%) eculizumab-treated patients, compared with none of 44 placebo-treated patients. Eculizumab-treated patients required significantly fewer RBC transfusions than placebo-treated patients (median, 0 versus 10 units). There was also a significant reduction in the serum lactate dehydrogenase area under the curve with eculizumab compared with placebo treatment. Results of the phase II supportive study were similar to those of the phase III study. The safety database included 196 adult patients with PNH. Significant findings included the development of human anti-human antibody responses in three patients and serious meningococcal infections in three patients. Patients should undergo meningococcal vaccination at least 2 weeks prior to receiving the first eculizumab treatment and have revaccination according to current medical guidelines. Patients must be monitored and evaluated immediately for early signs of meningococcal infections and treated with antibiotics as indicated.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
U2 - PMID: 18784156.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lee, Colleen O.
AU - Coe, Alyssa
T1 - Knowledge Central.
JO - Oncology Nursing Forum
JF - Oncology Nursing Forum
Y1 - 2008/09//
VL - 35
IS - 5
M3 - Book Review
SP - 852
EP - 853
PB - Oncology Nursing Society
SN - 0190535X
AB - The article reviews several books on cancer including "Integrative Oncology: Incorporating Complementary Medicine Into Conventional Cancer Care," by Lorenzo Cohen and Maurie Markman, "Medicine Hands: Massage Therapy for People With Cancer," by Gayle MacDonald, and "Health Disparities in the United States: Social Class, Race, Ethnicity and Health," by Donald A. Barr.
KW - NONFICTION
KW - COHEN, Lorenzo
KW - MARKMAN, Maurie
KW - MACDONALD, Gayle
KW - BARR, Donald A.
KW - INTEGRATIVE Oncology: Incorporating Complementary Medicine Into Conventional Cancer Care (Book)
KW - MEDICINE Hands: Massage Therapy for People With Cancer (Book)
KW - HEALTH Disparities in the United States: Social Class, Race, Ethnicity & Health (Book)
N1 - Accession Number: 34114433; Lee, Colleen O. 1 Coe, Alyssa 2; Affiliation: 1: Commander, U.S. Public Health Service, Practice Assessment Program Manager, National Institutes of Health, National Cancer Institute, Office of Cancer Complementary and Alternative Medicine, Rockville, MD 2: St. John of God Hospital, Geelong, Australia; Source Info: Sep2008, Vol. 35 Issue 5, p852; Subject Term: NONFICTION; Reviews & Products: INTEGRATIVE Oncology: Incorporating Complementary Medicine Into Conventional Cancer Care (Book); Reviews & Products: MEDICINE Hands: Massage Therapy for People With Cancer (Book); Reviews & Products: HEALTH Disparities in the United States: Social Class, Race, Ethnicity & Health (Book); People: COHEN, Lorenzo; People: MARKMAN, Maurie; People: MACDONALD, Gayle; People: BARR, Donald A.; Number of Pages: 2p; Illustrations: 4 Black and White Photographs; Document Type: Book Review
L3 - 10.1188/08.ONF.852-853
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rongjun Wang
AU - Jinchan Wang
AU - Mingfei Sun
AU - Hailiang Dang
AU - Yaoyu Feng
AU - Changshen Ning
AU - Fuchun Jian
AU - Longxian Zhang
AU - Lihua Xiao
T1 - Molecular characterization of the Cryptosporidium cervine genotype from a sika deer ( Cervus nippon Temminck) in Zhengzhou, China and literature review.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2008/09//
VL - 103
IS - 4
M3 - Article
SP - 865
EP - 869
SN - 09320113
AB - Abstract A total of 124 fecal specimens were collected from four deer farms in Zhengzhou City, China and examined for Cryptosporidium by Sheather’s sugar flotation technique. Cryptosporidim oocysts were detected in two 1-year-old sika deer, and one of the two specimens was genotyped by sequence and phylogenetic analyses of the small subunit ribosomal RNA (rRNA) (18S rRNA), 70-kDa heat shock protein (HSP70), actin, and Cryptosporidium oocyst wall protein (COWP) genes. Results obtained suggested that the Cryptosporidium studied belonged to Cryptosporidium cervine genotype, although slight sequence differences were noticed at the three loci. The similarities between this isolate and other Cryptosporidium cervine genotype isolates were 99.1–99.8%, 9.8%, 99.7%, and 100% at the 18S rRNA, HSP70, actin, and COWP loci, respectively. This study is the first report of Cryptosporidium infection in sika deer in China. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CRYPTOSPORIDIUM
KW - SIKA deer
KW - RNA
KW - PHYLOGENY
KW - HEAT shock proteins
KW - ACTIN
KW - CHINA
N1 - Accession Number: 33395782; Rongjun Wang 1 Jinchan Wang 1 Mingfei Sun 1 Hailiang Dang 1 Yaoyu Feng 2 Changshen Ning 1 Fuchun Jian 1 Longxian Zhang 1 Lihua Xiao 3; Affiliation: 1: Henan Agricultural University The College of Animal Science and Veterinary Medicine Zhengzhou 450002 People’s Republic of China 2: East China University of Science and Technology School of Resource and Environmental Engineering Shanghai 200237 People’s Republic of China 3: Centers for Disease Control and Prevention US Department of Health and Human Services, Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases Atlanta GA 30341 USA; Source Info: Sep2008, Vol. 103 Issue 4, p865; Subject Term: CRYPTOSPORIDIUM; Subject Term: SIKA deer; Subject Term: RNA; Subject Term: PHYLOGENY; Subject Term: HEAT shock proteins; Subject Term: ACTIN; Subject Term: CHINA; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pope, Stanley J.
AU - Holick, Michael F.
AU - Mackin, Steven
AU - Godar, Dianne E.
T1 - Action Spectrum Conversion Factors that Change Erythemally Weighted to Previtamin D3-weighted UV Doses.
JO - Photochemistry & Photobiology
JF - Photochemistry & Photobiology
Y1 - 2008/09//
VL - 84
IS - 5
M3 - Article
SP - 1277
EP - 1283
SN - 00318655
AB - Many solar UV measurements, either terrestrial or personal, weight the raw data by the erythemal action spectrum. However, a problem arises when one tries to estimate the benefit of vitamin D3 production based on erythemally weighted outdoor doses, like those measured by calibrated R-B meters or polysulphone badges, because the differences between action spectra give dissimilar values. While both action spectra peak in the UVB region, the erythemal action spectrum continues throughout the UVA region while the previtamin D3 action spectrum stops near that boundary. When one uses the previtamin D3 action spectrum to weight the solar spectra ( Deff), one gets a different contribution in W m−2 than what the erythemally weighted data predicts ( Eeff). Thus, to do proper benefit assessments, one must incorporate action spectrum conversion factors (ASCF) into the calculations to change erythemally weighted to previtamin D3-weighted doses. To date, all benefit assessments for vitamin D3 production in human skin from outdoor exposures are overestimates because they did not account for the different contributions of each action spectrum with changing solar zenith angle and ozone and they did not account for body geometry. Here we describe how to normalize the ratios of the effective irradiances ( Deff/ Eeff) to get ASCF that change erythemally weighted to previtamin D3-weighted doses. We also give the ASCF for each season of the year in the northern hemisphere every 5° from 30°N to 60°N, based on ozone values. These ASCF, along with geometry conversion factors and other information, can give better vitamin D3 estimates from erythemally weighted outdoor doses. [ABSTRACT FROM AUTHOR]
AB - Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHOLECALCIFEROL
KW - RESEARCH
KW - ACTION spectrum
KW - ERYTHEMA
KW - ULTRAVIOLET radiation
KW - EVALUATION
KW - PHOTOBIOLOGY
N1 - Accession Number: 34037813; Pope, Stanley J. 1 Holick, Michael F. 2 Mackin, Steven 3 Godar, Dianne E. 4; Email Address: dianne.godar@fda.hhs.gov; Affiliation: 1: Sun Systems & Svc, Inc., Oak Park, MI 2: Boston School of Medicine, Boston, MA 3: Solartech, Inc., Harrison Township, MI 4: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD; Source Info: Sep2008, Vol. 84 Issue 5, p1277; Subject Term: CHOLECALCIFEROL; Subject Term: RESEARCH; Subject Term: ACTION spectrum; Subject Term: ERYTHEMA; Subject Term: ULTRAVIOLET radiation; Subject Term: EVALUATION; Subject Term: PHOTOBIOLOGY; Number of Pages: 7p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1751-1097.2008.00373.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brown, Larry K.
AU - DiClemente, Ralph
AU - Crosby, Richard
AU - Fernandez, M. Isabel
AU - Pugatch, David
AU - Cohn, Sylvia
AU - Lescano, Celia
AU - Royal, Scott
AU - Murphy, Jacqueline R.
AU - Silver, Barbara
AU - Schlenger, William E.
T1 - Condom Use Among High-Risk Adolescents: Anticipation of Partner Disapproval and Less Pleasure Associated with Not Using Condoms.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2008/09//Sep/Oct2008
VL - 123
IS - 5
M3 - Article
SP - 601
EP - 607
SN - 00333549
AB - Objective. We determined the association of demographic, psychosocial, and contextual factors with condom use among a large community sample of at-risk adolescents recruited from four locations in the U.S. Methods, We enrolled 1,410 adolescents/young adults between the ages of 15 and 21 with a history of unprotected sex in the past 90 days at four study sites. Subjects completed an audio-assisted, computerized assessment that gathered information about sexual behavior and its contexts, substance use, and relevant risk and protective attitudes. Results. Nearly two-thirds of adolescents did not use condoms at the time of last intercourse and adolescents reported a mean of 15.5 (median = 5) unprotected intercourse occasions in the past 90 days. Controlling for relevant demographic variables, not using condoms was associated with the perception that condoms reduce sexual pleasure, the perception that partners will not approve of condom use, and less discussion with partners about condoms. Conclusions. Even across racial/ethnic groups, gender, and geographic locations, several important correlates of adolescents' sexual risk reduction were identified. Many adolescents may feel that condoms reduce their sexual pleasure and fear partner reactions if they initiate condom use. These attitudes may be malleable through clinical and community-based interventions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONDOMS
KW - TEENAGERS
KW - SEXUAL intercourse
KW - SUBSTANCE abuse
KW - UNITED States
N1 - Accession Number: 34049228; Brown, Larry K. 1; Email Address: lkbrown@lifespan.org DiClemente, Ralph 2 Crosby, Richard 2 Fernandez, M. Isabel 3 Pugatch, David 4 Cohn, Sylvia 5 Lescano, Celia 1 Royal, Scott 5 Murphy, Jacqueline R. 5 Silver, Barbara 6 Schlenger, William E. 5; Affiliation: 1: Rhode Island Hospital, Providence, RI 2: Emory University, Atlanta, GA 3: University of Miami, Miami, FL 4: Miriam Hospital, Providence, RI 5: Research Triangle Institute, Research Triangle Park, NC 6: Substance Abuse and Mental Health Services Administration, Rockville, MD; Source Info: Sep/Oct2008, Vol. 123 Issue 5, p601; Subject Term: CONDOMS; Subject Term: TEENAGERS; Subject Term: SEXUAL intercourse; Subject Term: SUBSTANCE abuse; Subject Term: UNITED States; NAICS/Industry Codes: 326299 All Other Rubber Product Manufacturing; NAICS/Industry Codes: 326290 Other rubber product manufacturing; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hong, Yun-Hee
AU - Park, Ji-Yong
AU - Park, Jong-Hyun
AU - Chung, Myong-Soo
AU - Kwon, Ki-Sung
AU - Chung, Kyungsook
AU - Won, Misun
AU - Song, Kyung-Bin
T1 - Inactivation of Enterobacter sakazakii, Bacillus cereus, and Salmonella typhimurium in powdered weaning food by electron-beam irradiation
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2008/09//
VL - 77
IS - 9
M3 - Article
SP - 1097
EP - 1100
SN - 0969806X
AB - Abstract: Inactivation of Enterobacter sakazakii, Bacillus cereus, and Salmonella typhimurium were evaluated in powdered weaning food using electron-beam irradiation. E. sakazakii, B. cereus, and S. typhimurium were eliminated by irradiation at 16, 8, and 8kGy, respectively. The D 10-vlaues of E. sakazakii, B. cereus, and S. typhimurium inoculated on powdered weaning food were 4.83, 1.22, and 0.98kGy, respectively. The results suggest that electron-beam irradiation should inhibit the growth of pathogenic bacteria on baby food without impairing qualities. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLES (Nuclear physics)
KW - NUCLEAR physics
KW - COLLISIONS (Nuclear physics)
KW - LATTICE gauge theories
KW - POLARIZATION (Nuclear physics)
KW - PIONS
KW - Electron-beam irradiation
KW - Microbial growth
KW - Powdered weaning food
N1 - Accession Number: 34089487; Hong, Yun-Hee 1 Park, Ji-Yong 2 Park, Jong-Hyun 3 Chung, Myong-Soo 4 Kwon, Ki-Sung 5 Chung, Kyungsook 6 Won, Misun 6 Song, Kyung-Bin 1; Email Address: kbsong@cnu.ac.kr; Affiliation: 1: Department of Food Science and Technology, College of Agriculture and Life Science, Chungnam National University, Yuseong-Gu, Daejeon 305-764, Republic of Korea 2: Department of Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea 3: Department of Food Science and Biotechnology, Kyungwon University, Sungnam 461-701, Republic of Korea 4: Department of Food Science, Ehwa Women's University, Seoul 120-750, Republic of Korea 5: Center for Food safety Evaluation, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea 6: Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea; Source Info: Sep2008, Vol. 77 Issue 9, p1097; Subject Term: PARTICLES (Nuclear physics); Subject Term: NUCLEAR physics; Subject Term: COLLISIONS (Nuclear physics); Subject Term: LATTICE gauge theories; Subject Term: POLARIZATION (Nuclear physics); Subject Term: PIONS; Author-Supplied Keyword: Electron-beam irradiation; Author-Supplied Keyword: Microbial growth; Author-Supplied Keyword: Powdered weaning food; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2008.05.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kirby, James B.
T1 - Poor People, Poor Places and Access to Health Care in the United States.
JO - Social Forces
JF - Social Forces
Y1 - 2008/09//
VL - 87
IS - 1
M3 - Article
SP - 325
EP - 355
SN - 00377732
AB - Research suggests that community-level poverty is associated with access to health care net of individual-level characteristics, but no research investigates whether this association differs by individual-level income. Using data from the 2000 Medical Expenditure Panel Survey, the US Census Bureau, and the Health Resource and Services Administration, the article finds that the negative relationship between the prevalence of poverty in communities and access to health care is much stronger for middle- and high-income individuals than for those in lower-income groups. The article suggests that individuals may benefit from living among those in similar economic circumstances because they face similar obstacles to obtaining medical care. For poor individuals, the collective knowledge and experience embedded in poor communities may compensate for the otherwise negative influence of community-level poverty. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Forces is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POVERTY -- United States
KW - MEDICAL care -- United States
KW - COMMUNITIES
KW - SOCIOECONOMIC factors
KW - INCOME -- United States
KW - POOR people -- United States
KW - ECONOMIC history
KW - MEDICAL care
KW - INCOME
KW - POOR people
KW - UNITED States
N1 - Accession Number: 35369779; Kirby, James B. 1; Email Address: kirby@ahrq.gov; Affiliations: 1 : Agency for Healthcare Research and Quality; Source Info: Sep2008, Vol. 87 Issue 1, p325; Historical Period: 2000; Subject Term: POVERTY -- United States; Subject Term: MEDICAL care -- United States; Subject Term: COMMUNITIES; Subject Term: SOCIOECONOMIC factors; Subject Term: INCOME -- United States; Subject Term: POOR people -- United States; Subject Term: ECONOMIC history; Subject Term: MEDICAL care; Subject Term: INCOME; Subject Term: POOR people; Subject: UNITED States; Number of Pages: 30p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Mnatsakanov, Robert M.
T1 - Hausdorff moment problem: Reconstruction of distributions
JO - Statistics & Probability Letters
JF - Statistics & Probability Letters
Y1 - 2008/09//
VL - 78
IS - 12
M3 - Article
SP - 1612
EP - 1618
SN - 01677152
AB - Abstract: The problem of approximation of the moment-determinate cumulative distribution function (cdf) from its moments is studied. This method of recovering an unknown distribution is natural in certain incomplete models like multiplicative-censoring or biased sampling when the moments of unobserved distributions are related in a simple way to the moments of an observed distribution. In this article some properties of the proposed construction are derived. The uniform and -rates of convergence of the approximated cdf to the target distribution are obtained. [Copyright &y& Elsevier]
AB - Copyright of Statistics & Probability Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISTRIBUTION (Probability theory)
KW - PROBABILITY theory
KW - MOMENT problems (Mathematics)
KW - STOCHASTIC convergence
KW - -rate of approximation
KW - Hausdorff moment problem
KW - Moment-recovered distribution
KW - Uniform rate of approximation
N1 - Accession Number: 33992149; Mnatsakanov, Robert M. 1,2; Email Address: rmnatsak@stat.wvu.edu; Affiliation: 1: Department of Statistics, West Virginia University, P.O. Box 6330, Morgantown, WV 26506, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Sep2008, Vol. 78 Issue 12, p1612; Subject Term: DISTRIBUTION (Probability theory); Subject Term: PROBABILITY theory; Subject Term: MOMENT problems (Mathematics); Subject Term: STOCHASTIC convergence; Author-Supplied Keyword: -rate of approximation; Author-Supplied Keyword: Hausdorff moment problem; Author-Supplied Keyword: Moment-recovered distribution; Author-Supplied Keyword: Uniform rate of approximation; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.spl.2008.01.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, A.A.
AU - Kisin, E.R.
AU - Murray, A.R.
AU - Kommineni, C.
AU - Castranova, V.
AU - Fadeel, B.
AU - Kagan, V.E.
T1 - Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/09//
VL - 231
IS - 2
M3 - Article
SP - 235
EP - 240
SN - 0041008X
AB - Abstract: Single-walled carbon nanotubes (SWCNT) have been introduced into a large number of new technologies and consumer products. The combination of their exceptional features with very broad applications raised concerns regarding their potential health effects. The prime target for SWCNT toxicity is believed to be the lung where exposure may occur through inhalation, particularly in occupational settings. Our previous work has demonstrated that SWCNT cause robust inflammatory responses in rodents with very early termination of the acute phase and rapid onset of chronic fibrosis. Timely elimination of polymorphonuclear neutrophils (PMNs) through apoptosis and their subsequent clearance by macrophages is a necessary stage in the resolution of pulmonary inflammation whereby NADPH oxidase contributes to control of apoptotic cell death and clearance of PMNs. Thus, we hypothesized that NADPH oxidase may be an important regulator of the transition from the acute inflammation to the chronic fibrotic stage in response to SWCNT. To experimentally address the hypothesis, we employed NADPH oxidase-deficient mice which lack the gp91phox subunit of the enzymatic complex. We found that NADPH oxidase null mice responded to SWCNT exposure with a marked accumulation of PMNs and elevated levels of apoptotic cells in the lungs, production of pro-inflammatory cytokines, decreased production of the anti-inflammatory and pro-fibrotic cytokine, TGF-β, and significantly lower levels of collagen deposition, as compared to C57BL/6 control mice. These results demonstrate a role for NADPH oxidase-derived reactive oxygen species in determining course of pulmonary response to SWCNT. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUTROPHILS
KW - NANOTUBES
KW - IMMUNE response -- Regulation
KW - PULMONARY fibrosis
KW - Inflammation
KW - Lung disease
KW - Nanoparticles
KW - Oxidative enzymes
KW - Pulmonary injury
N1 - Accession Number: 34001925; Shvedova, A.A. 1,2; Email Address: ats1@cdc.gov Kisin, E.R. 1 Murray, A.R. 1,2 Kommineni, C. 1 Castranova, V. 1,2,3 Fadeel, B. 4 Kagan, V.E. 1,3; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA 2: Physiology and Pharmacology Department, West Virginia University, Morgantown, WV, USA 3: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 4: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institute Stockholm, Sweden; Source Info: Sep2008, Vol. 231 Issue 2, p235; Subject Term: NEUTROPHILS; Subject Term: NANOTUBES; Subject Term: IMMUNE response -- Regulation; Subject Term: PULMONARY fibrosis; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Lung disease; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: Oxidative enzymes; Author-Supplied Keyword: Pulmonary injury; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.taap.2008.04.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34001925&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Flynn, Thomas J.
AU - Ferguson, Martine S.
T1 - Multiendpoint mechanistic profiling of hepatotoxicants in HepG2/C3A human hepatoma cells and novel statistical approaches for development of a prediction model for acute hepatotoxicity
JO - Toxicology in Vitro
JF - Toxicology in Vitro
Y1 - 2008/09//
VL - 22
IS - 6
M3 - Article
SP - 1618
EP - 1631
SN - 08872333
AB - Abstract: HepG2/C3A human hepatoma cells were exposed to serial concentrations of seven known hepatotoxicants for 48h. Six endpoint assays were selected to model different mechanisms of acute hepatotoxicity. Each compound produced a unique concentration–response pattern across all endpoints. The endpoints did not correlate strongly, suggesting that each endpoint monitored an independent cellular process. Prediction models were developed using five statistical methods. The models used only known hepatotoxicants for the training set. The zero concentration (control) and all concentrations not significantly different from control were programmed as non-toxic levels and concentrations significantly different from control as toxic levels. So, rather than a binary classification of each compound (i.e., toxic or non-toxic), the models gave a prediction of the concentration, if any, at which a compound showed behavior similar to liver toxicants at their toxic concentrations. The discriminant analysis model gave the best overall performance with positive and negative predictive values of 1.00 and 0.83, respectively. Ten additional compounds were tested using this prediction model. The model predicted liver active concentrations for each compound that were consistent with their known biologically active concentrations. This model system may be useful for predicting concentration levels at which unknown compounds would display undesirable liver activity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology in Vitro is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisons
KW - Hepatotoxicology
KW - Cancer cells
KW - Hepatoma
KW - Discriminant analysis
KW - Prediction models
KW - Hepatotoxicity
KW - HepG2/C3A cells
KW - Mechanistic profiling
KW - Prediction model
N1 - Accession Number: 33887079; Flynn, Thomas J. 1; Email Address: thomas.flynn@fda.hhs.gov; Ferguson, Martine S. 2; Email Address: martine.ferguson@fda.hhs.gov; Affiliations: 1: FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, US FDA, MOD-1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708-2476, United States; 2: FDA, Center for Food Safety and Applied Nutrition, Division of Public Health and Biostatistics, College Park, MD 20740, United States; Issue Info: Sep2008, Vol. 22 Issue 6, p1618; Thesaurus Term: Poisons; Subject Term: Hepatotoxicology; Subject Term: Cancer cells; Subject Term: Hepatoma; Subject Term: Discriminant analysis; Subject Term: Prediction models; Author-Supplied Keyword: Hepatotoxicity; Author-Supplied Keyword: HepG2/C3A cells; Author-Supplied Keyword: Mechanistic profiling; Author-Supplied Keyword: Prediction model; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.tiv.2008.04.016
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Selvapandiyan, Angamuthu
AU - Duncan, Robert
AU - Mendez, Juan
AU - Kumar, Rajesh
AU - Salotra, Poonam
AU - Cardo, Lisa J.
AU - Nakhasi, Hira L.
T1 - A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates.
JO - Transfusion
JF - Transfusion
Y1 - 2008/09//
VL - 48
IS - 9
M3 - Article
SP - 1787
EP - 1798
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species. STUDY DESIGN AND METHODS: The kinetoplast minicircle DNA is known to have heterogeneity in sequence and is present in many thousands of copies in Leishmania. Fluorescence-based polymerase chain reaction (PCR) was used to amplify minicircle DNA from six Leishmania species from different geographic locations. The sequences were then used to construct a phylogenetic tree. Speciation of 46 blinded parasite clinical isolates from various geographic regions was validated using the assay. RESULTS: Analysis displayed a distinct cluster for each species or strain. Forty-three of 46 isolates were correctly assigned to the same species identified by isoenzyme electrophoresis. The three untyped isolates were all either new species or samples from a unique geographic region. The minicircles of the three isolates formed new clusters in the tree analysis. Using minicircle DNA as PCR target, the sensitivity of the parasite detection in the spiked blood samples was five parasites per mL. CONCLUSION: Increased sensitivity and speciation without the need for parasite culture will be useful for diagnosis and treatment in clinical settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEISHMANIA
KW - BLOOD parasites
KW - POLYMERASE chain reaction
KW - ISOENZYMES
KW - ELECTROPHORESIS
KW - PHYLOGENY
N1 - Accession Number: 34081090; Selvapandiyan, Angamuthu 1,2,3; Email Address: angamuthu.selvapandiyan@fda.hhs.gov Duncan, Robert 1,2,3 Mendez, Juan 1,2,3 Kumar, Rajesh 1,2,3 Salotra, Poonam 1,2,3 Cardo, Lisa J. 1,2,3 Nakhasi, Hira L. 1,2,3; Affiliation: 1: Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Department of Blood Research, Transfusion Medicine Branch,Walter Reed Army Institute of Research, Silver Spring, Maryland 3: Institute of Pathology (Indian Council of Medical Research), Safdarjung Hospital, New Delhi, India; Source Info: Sep2008, Vol. 48 Issue 9, p1787; Subject Term: LEISHMANIA; Subject Term: BLOOD parasites; Subject Term: POLYMERASE chain reaction; Subject Term: ISOENZYMES; Subject Term: ELECTROPHORESIS; Subject Term: PHYLOGENY; Number of Pages: 12p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1537-2995.2008.01798.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCullough, Jeffrey
AU - Kahn, Jeffrey
AU - Adamson, John
AU - Anderlini, Paolo
AU - Benjamin, Richard
AU - Confer, Dennis
AU - Eapen, Mary
AU - Hirsch, Betsy
AU - Kuter, David
AU - Lazarus, Ellen
AU - Pamphilon, Derwood
AU - Stroncek, David
AU - Sugarman, Jeremy
AU - Wilson, Robert
T1 - Hematopoietic growth factors—use in normal blood and stem cell donors: clinical and ethical issues.
JO - Transfusion
JF - Transfusion
Y1 - 2008/09//
VL - 48
IS - 9
M3 - Article
SP - 2008
EP - 2025
PB - Wiley-Blackwell
SN - 00411132
AB - Information about several papers discussed at a conference about clinical and ethical issues on hematopoietic growth factors use in normal blood and stem cell donors is presented. Topics include basic science, clinical effects and uses, side effects, and theoretical complications of hematopoietic growth factors. The conference featured several speakers including John Adamson, Paolo Anderlini, and Richard Benjamin.
KW - CONFERENCES & conventions
KW - HEMATOPOIETIC growth factors
KW - BLOOD donors
KW - HEALTH
KW - STEM cell research
KW - CONGRESSES
KW - ADAMSON, John
KW - ANDERLINI, Paolo
KW - BENJAMIN, Richard
N1 - Accession Number: 34081099; McCullough, Jeffrey 1,2,3,4,5,6,7,8,9; Email Address: mccul001@umn.edu Kahn, Jeffrey 1,2,3,4,5,6,7,8,9 Adamson, John 1,2,3,4,5,6,7,8,9 Anderlini, Paolo 1,2,3,4,5,6,7,8,9 Benjamin, Richard 1,2,3,4,5,6,7,8,9 Confer, Dennis 1,2,3,4,5,6,7,8,9 Eapen, Mary 1,2,3,4,5,6,7,8,9 Hirsch, Betsy 1,2,3,4,5,6,7,8,9 Kuter, David 1,2,3,4,5,6,7,8,9 Lazarus, Ellen 1,2,3,4,5,6,7,8,9 Pamphilon, Derwood 1,2,3,4,5,6,7,8,9 Stroncek, David 1,2,3,4,5,6,7,8,9 Sugarman, Jeremy 1,2,3,4,5,6,7,8,9 Wilson, Robert 1,2,3,4,5,6,7,8,9; Affiliation: 1: University of Minnesota and National Marrow Donor Program, Minneapolis, Minnesota 2: Blood Center of Wisconsin and Medical College of Wisconsin, Milwaukee,Wisconsin 3: MD Anderson Cancer Center, Houston, Texas 4: American Red Cross Biomedical Services,Washington, DC 5: Massachusetts General Hospital, Boston, Massachusetts 6: Food and Drug Administration, Rockville, Maryland 7: University of Bristol, Bristol, UK 8: National Institutes of Health, Bethesda, Maryland 9: Johns Hopkins University, Baltimore, Maryland; Source Info: Sep2008, Vol. 48 Issue 9, p2008; Subject Term: CONFERENCES & conventions; Subject Term: HEMATOPOIETIC growth factors; Subject Term: BLOOD donors; Subject Term: HEALTH; Subject Term: STEM cell research; Subject Term: CONGRESSES; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; People: ADAMSON, John; People: ANDERLINI, Paolo; People: BENJAMIN, Richard; Number of Pages: 18p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1111/j.1537-2995.2008.01788.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105553256
T1 - A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates.
AU - Selvapandiyan A
AU - Duncan R
AU - Mendez J
AU - Kumar R
AU - Salotra P
AU - Cardo LJ
AU - Nakhasi HL
Y1 - 2008/09//
N1 - Accession Number: 105553256. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. Grant Information: CBER/OBRR; and US Army Combat Casualty Care Research Program, Medical Research and Materiel Command. NLM UID: 0417360.
KW - DNA Footprinting -- Methods
KW - Genetics
KW - Leishmania
KW - DNA -- Analysis
KW - Funding Source
KW - Geographic Factors
KW - Leishmania -- Classification
KW - Leishmaniasis -- Diagnosis
KW - Leishmaniasis -- Microbiology
KW - Polymerase Chain Reaction -- Methods
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Validation Studies
KW - Human
SP - 1787
EP - 1798
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 48
IS - 9
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND: Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species. STUDY DESIGN AND METHODS: The kinetoplast minicircle DNA is known to have heterogeneity in sequence and is present in many thousands of copies in Leishmania. Fluorescence-based polymerase chain reaction (PCR) was used to amplify minicircle DNA from six Leishmania species from different geographic locations. The sequences were then used to construct a phylogenetic tree. Speciation of 46 blinded parasite clinical isolates from various geographic regions was validated using the assay. RESULTS: Analysis displayed a distinct cluster for each species or strain. Forty-three of 46 isolates were correctly assigned to the same species identified by isoenzyme electrophoresis. The three untyped isolates were all either new species or samples from a unique geographic region. The minicircles of the three isolates formed new clusters in the tree analysis. Using minicircle DNA as PCR target, the sensitivity of the parasite detection in the spiked blood samples was five parasites per mL. CONCLUSION: Increased sensitivity and speciation without the need for parasite culture will be useful for diagnosis and treatment in clinical settings.
SN - 0041-1132
AD - Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD; angamuthu.selvapandiyan@fda.hhs.gov
U2 - PMID: 18564397.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105553256&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2008-12910-005
AN - 2008-12910-005
AU - Siahpush, Mohammad
AU - Spittal, Matt
AU - Singh, Gopal K.
T1 - Happiness and life satisfaction prospectively predict self-rated health, physical health and the presence of limiting, long-term health conditions.
JF - American Journal of Health Promotion
JO - American Journal of Health Promotion
JA - Am J Health Promot
Y1 - 2008/09//Sep-Oct, 2008
VL - 23
IS - 1
SP - 18
EP - 26
CY - US
PB - American Journal of Health Promotion
SN - 0890-1171
SN - 2168-6602
AD - Siahpush, Mohammad, Department of Health Promotion, Social and Behavioral Health Sciences, College of Public Health, University of Nebraska Medical Center, 986075 Nebraska Medical Center, Omaha, NE, US, 68198-6075
N1 - Accession Number: 2008-12910-005. PMID: 18785370 Partial author list: First Author & Affiliation: Siahpush, Mohammad; Department of Health Promotion, Social and Behavioral Health Sciences, College of Public Health, University of Nebraska Medical Center, Omaha, NE, US. Other Publishers: Sage Publications. Release Date: 20081110. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Siahpush, Mohammad. Major Descriptor: Happiness; Health; Life Satisfaction; Physical Health. Minor Descriptor: Self-Evaluation. Classification: Personality Psychology (3100). Population: Human (10); Male (30); Female (40). Location: Australia. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: SF-36 Health Survey. Methodology: Empirical Study; Followup Study; Longitudinal Study; Quantitative Study. Page Count: 9. Issue Publication Date: Sep-Oct, 2008.
AB - Purpose: To examine the effect of happiness and life satisfaction on health. Design: Longitudinal data from waves 1 and 3, conducted in 2001 and 2004, respectively, of the Household Income and Labour Dynamics in Australia survey. Setting: Australia. Subjects: A total of 9981 respondents aged 18 years and older. Measures: Outcomes were self reported health; the absence of long-term, limiting health conditions; and physical health. Happiness was assessed with the following question: 'During the past 4 weeks, have you been a happy person'? Life satisfaction was determined, with the following question: 'All things considered, how satisfied are you with your life'? Analysis: We used multiple regression analysis to estimate odds ratios (ORs), beta coefficients (β̂), and 95% confidence intervals (CIs) for the associations between baseline happiness or life satisfaction and health at wave 3. Results: Baseline happiness and life satisfaction both were positively associated at wave 3 with excellent, very good, or good health (OR = 1.50, CI = 1.33-1.70, p < .0001; and OR = 1.62, CI = 1.27-2.08, p < .0001, respectively); with the absence of long-term, limiting health conditions (OR = 1.53, CI = 1.35-1.75, p < .0001; and OR = 1.51, CI = 1.25-1.82, p < .0001, respectively); and with higher physical health levels β̂ = .99, CI = .60-1.39, p < .0001; and β̂ = .99, CI = .20-1.78, p < .0145, respectively). Conclusion: This study showed that happier people and those who were more satisfied with their lives at baseline reported better health (self-rated health; absence of limiting, long-term conditions; and physical health) at the 2-year follow-up when adjusted for baseline health and other relevant covariates. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - happiness
KW - life satisfaction
KW - self-rated health
KW - physical health
KW - long-term health conditions
KW - 2008
KW - Happiness
KW - Health
KW - Life Satisfaction
KW - Physical Health
KW - Self-Evaluation
KW - 2008
U1 - Sponsor: Victorian Health Promotion Foundation (VicHealth), Australia. Recipients: Siahpush, Mohammad
DO - 10.4278/ajhp.061023137
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12910-005&site=ehost-live&scope=site
UR - msiahpush@unmc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11979-014
AN - 2008-11979-014
AU - Lucksted, Alicia
AU - Stewart, Bette
AU - Forbes, Courtney B.
T1 - Benefits and changes for family to family graduates.
JF - American Journal of Community Psychology
JO - American Journal of Community Psychology
JA - Am J Community Psychol
Y1 - 2008/09//
VL - 42
IS - 1-2
SP - 154
EP - 166
CY - Germany
PB - Springer
SN - 0091-0562
SN - 1573-2770
AD - Lucksted, Alicia, Center for Mental Health Services Research, Division of Services Research, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard Street, Rm 528, Baltimore, MD, US, 21201
N1 - Accession Number: 2008-11979-014. PMID: 18597167 Partial author list: First Author & Affiliation: Lucksted, Alicia; VA Capitol Healthcare Network (VISN 5), Mental Illness Research, Education, and Clinical Center (MIRECC), Baltimore, MD, US. Other Publishers: Kluwer Academic/Plenum Publishers; Plenum Publishing Corp.; Wiley-Blackwell Publishing Ltd. Release Date: 20080915. Correction Date: 20160125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Caregiver Burden; Educational Programs; Empowerment; Mental Disorders; Self-Help Techniques. Minor Descriptor: Family Members. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. Page Count: 13. Issue Publication Date: Sep, 2008.
AB - Family members of people with serious mental illnesses (SMI) need information and support to cope with the considerable stresses they experience. The Family to Family Education Program (FtF) is a structured, peer-led, 12-week information and support self-help class for such individuals. Previous research by Dixon et al. (2004) shows reduced subjective burden and increased empowerment among graduates. The present study sought to understand what processes take place during FtF participation that might lead to these benefits, as a first step in building a conceptual model of how FtF causes its effects, using semi-structured interviews with 31 FtF graduates. Qualitative data analysis suggested that new factual and emotional information from FtF shifts interviewees' understanding of their situation and that skills acquired through FtF then allow participants to incorporate these new perspectives into more adaptive behaviors. These changes led to both proximal and distal benefits for the FtF participants interviewed. The results are discussed in the context of self-help, stress-and-coping, and trauma recovery theories. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Family to Family Education Program
KW - serious mental illnesses
KW - family members
KW - subjective burden
KW - empowerment
KW - graduates
KW - self help
KW - 2008
KW - Caregiver Burden
KW - Educational Programs
KW - Empowerment
KW - Mental Disorders
KW - Self-Help Techniques
KW - Family Members
KW - 2008
U1 - Sponsor: Women's Health Research Group. Recipients: No recipient indicated
U1 - Sponsor: University of Maryland, Department of Epidemiology & Preventive Medicine, US. Recipients: No recipient indicated
DO - 10.1007/s10464-008-9195-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11979-014&site=ehost-live&scope=site
UR - aluckste@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12406-001
AN - 2008-12406-001
AU - Galson, Steven K.
T1 - Surgeon General's perspectives: Childhood overweight and obesity prevention.
JF - Bariatric Nursing and Surgical Patient Care
JO - Bariatric Nursing and Surgical Patient Care
Y1 - 2008/09//
VL - 3
IS - 3
SP - 175
EP - 176
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1557-1459
N1 - Accession Number: 2008-12406-001. Other Journal Title: Bariatric Surgical Practice and Patient Care. Partial author list: First Author & Affiliation: Galson, Steven K.; U.S. Public Health Service, US. Release Date: 20090907. Correction Date: 20140331. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Editorial. Language: English. Major Descriptor: Childhood Development; Epidemics; Obesity; Overweight; Prevention. Minor Descriptor: Lifestyle; Public Health. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Page Count: 2. Issue Publication Date: Sep, 2008.
AB - The increase in childhood obesity is partly attributable to an increasingly sedentary lifestyle and poor nutrition. Sedentary behaviors such as television viewing, computer use, and video game playing often replace vigorous physical activity in children. At the same time, more fast foods, convenience store snacks, and sweetened beverages are available now than in past generations. As parents, caregivers, teachers, mentors, public health leaders, and other concerned citizens, it is our responsibility to take immediate action to mitigate this serious and growing public health epidemic. We can and must work collaboratively, using available science and evidence of effective programs to ensure that our children receive encouragement and guidance to make healthful choices for physical activity and good nutrition. Optimally, we act as role models, with our own health behaviors promoting a healthful lifestyle by example. This will result in a public health movement that will not only help reduce the burden of childhood overweight and obesity, but also lessen the occurrence of other chronic diseases such as diabetes, high blood pressure, and high cholesterol. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - children
KW - health promotion
KW - health prevention
KW - overweight
KW - obesity
KW - epidemics
KW - public health
KW - lifestyle
KW - 2008
KW - Childhood Development
KW - Epidemics
KW - Obesity
KW - Overweight
KW - Prevention
KW - Lifestyle
KW - Public Health
KW - 2008
DO - 10.1089/bar.2008.9968
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12406-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12275-020
AN - 2008-12275-020
AU - Schmued, Larry
AU - Bowyer, John
AU - Cozart, Matthew
AU - Heard, David
AU - Binienda, Zbigniew
AU - Paule, Merle
T1 - Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2008/09//
VL - 1229
SP - 210
EP - 217
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Schmued, Larry, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AZ, US, 72079
N1 - Accession Number: 2008-12275-020. PMID: 18657520 Partial author list: First Author & Affiliation: Schmued, Larry; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AZ, US. Release Date: 20080915. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Kainic Acid; Methamphetamine; Myelin Sheath. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2008.
AB - A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinated fibers. Specifically, it 1) allows for easier solution preparation, eliminating the need for extended heating or sonicating; 2) produces a more uniform and consistent tracer concentration, resulting in more consistent staining and 3) can be used at a 50% higher concentration, resulting in faster and more intense staining without the need for subsequent treatment with gold chloride intensifiers. To characterize the stain, both normal rat brains as well as those exposed to the neurotoxins kainic acid or methamphetamine were examined. The study also incorporates the first application of such stains to examine peripheral nerves of control and acrylamide-exposed rats. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Black-Gold II
KW - myelin
KW - methamphetamine
KW - kainic acid
KW - acrylamide
KW - Fluoro-Jade C
KW - sphingomyelin
KW - 2008
KW - Kainic Acid
KW - Methamphetamine
KW - Myelin Sheath
KW - Rats
KW - 2008
U1 - Sponsor: Food and Drug Administration. Grant: Protocol #E-7111.01. Recipients: No recipient indicated
DO - 10.1016/j.brainres.2008.06.129
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12275-020&site=ehost-live&scope=site
UR - larry.schmued@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11708-003
AN - 2008-11708-003
AU - Bakos, Alexis D.
AU - Hutson, Sadie P.
AU - Loud, Jennifer T.
AU - Peters, June A.
AU - Giusti, Ruthann M.
AU - Greene, Mark H.
T1 - BRCA mutation-negative women from hereditary breast and ovarian cancer families: A qualitative study of the BRCA-negative experience.
JF - Health Expectations: An International Journal of Public Participation in Health Care & Health Policy
JO - Health Expectations: An International Journal of Public Participation in Health Care & Health Policy
JA - Health Expect
Y1 - 2008/09//
VL - 11
IS - 3
SP - 220
EP - 231
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1369-6513
SN - 1369-7625
AD - Hutson, Sadie P., Division of Hematology/Oncology, Department of Internal Medicine, East Tennessee State University, VAMC Bldg 1, PO Box 70622, Rm 1–17, Johnson City, TN, US, 37614
N1 - Accession Number: 2008-11708-003. PMID: 18816319 Partial author list: First Author & Affiliation: Bakos, Alexis D.; Department of Health and Human Services, National Institute of Nursing Research, National Institutes of Health, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Loud, Jennifer T. Major Descriptor: Breast Neoplasms; Genetic Testing; Mutations; Neoplasms; Ovaries. Minor Descriptor: Family; Risk Perception. Classification: Cancer (3293). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Sep, 2008.
AB - Background: When women from families with a known BRCA1 or BRCA2 mutation test negative for the family mutation, it is assumed that they will transition their personal cancer risk perception from high to average risk. However, there are scant data regarding the experience of mutation-negative women after genetic testing disclosure, particularly related to the shift of risk perception from assumed mutation-positive to actual mutation-negative. This study was designed to explore cancer risk perception and the experience of being a mutation-negative woman within a known BRCA1/2 mutation-positive family. Methods: We employed a qualitative descriptive design and convened a sample of 13 women who contributed in-depth, semistructured telephone interviews (audio-recorded and transcribed verbatim) and performed qualitative content analysis with NVivo 2.0 software. Results: Six major content areas emerged from interview data: (i) rationale for initial involvement in the breast imaging study, (ii) rationale for continued participation, (iii) experience of living in a multiple-case family, (iv) risk perception: the personal meaning of mutation-negative status, (v) opinions regarding cancer aetiology and (vi) communication patterns between mutation-negative and mutation-positive family members. Conclusions: Living in a hereditary breast and ovarian cancer family is a complex experience that affects cognitive, emotional and social functioning. Our findings indicate that mutation-negative women may have unmet psychosocial needs that must be addressed by health-care professionals, particularly in the primary-care setting following genetic disclosure of a potentially reassuring result regarding their lack of the very high cancer risks associated with BRCA1/2 mutations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mutation test negative
KW - genetic testing disclosure
KW - family mutation
KW - personal cancer risk perception
KW - hereditary breast cancer
KW - ovarian cancer families
KW - 2008
KW - Breast Neoplasms
KW - Genetic Testing
KW - Mutations
KW - Neoplasms
KW - Ovaries
KW - Family
KW - Risk Perception
KW - 2008
U1 - Sponsor: National Cancer Institute, Intramural Research Program, US. Recipients: Loud, Jennifer T.; Peters, June A.; Greene, Mark H.
U1 - Sponsor: Westat. Grant: NO2-CP-11019-50; NO2-CP-65504-50. Other Details: NCI Protocol 01-C-0009. Recipients: No recipient indicated
DO - 10.1111/j.1369-7625.2008.00494.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11708-003&site=ehost-live&scope=site
UR - hutsons@mail.etsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15462-007
AN - 2008-15462-007
AU - Welbourne, Jennifer L.
AU - Hartley, Tara A.
AU - Ott, Sybil D.
AU - Robertson, Sherrilyn
T1 - Effects of risk-focused and recommendation-focused mental imagery on occupational risk communication.
JF - Health Communication
JO - Health Communication
JA - Health Commun
Y1 - 2008/09//
VL - 23
IS - 5
SP - 473
EP - 482
CY - United Kingdom
PB - Taylor & Francis
SN - 1041-0236
SN - 1532-7027
AD - Welbourne, Jennifer L., Department of Psychology, University of Texas Pan-American, 1201 West University Drive, Edinburg, TX, US, 78541-2999
N1 - Accession Number: 2008-15462-007. PMID: 18850394 Partial author list: First Author & Affiliation: Welbourne, Jennifer L.; Department of Psychology, University of Texas Pan-American, Edinburg, TX, US. Other Publishers: Lawrence Erlbaum. Release Date: 20090323. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Imagery; Occupational Safety; Risk Perception; Working Conditions. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2008.
AB - This study examined the impact of mental imagery instructions in a National Institute for Occupational Safety and Health (NIOSH) safety document conveying risk and safety information to farmers. A sample of 314 farmers recruited from a large Southeastern state fair was randomly assigned to conditions in a 2 × 2 design. Participants received a NIOSH safety document about skid steer loader safety in which 2 types of mental imagery instructions were manipulated: (a) risk-focused (imagery vs. control) and (b) recommendation-focused (imagery vs. control). Results indicate that risk-focused imagery influenced perceptions of susceptibility to workplace accidents, whereas recommendation-focused imagery influenced attitudes toward engaging in safety behaviors, intentions to share safety information with others, and perceptions of the safety message. Further analyses indicated that ease of imagery partially mediated the relationship between the imagery manipulations and these outcomes. Other potential mechanisms for these effects are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - occupational safety
KW - workplace health
KW - mental imagery
KW - risk communication
KW - 2008
KW - Imagery
KW - Occupational Safety
KW - Risk Perception
KW - Working Conditions
KW - 2008
DO - 10.1080/10410230802342168
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15462-007&site=ehost-live&scope=site
UR - welbournJL@utpa.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-06482-010
AN - 2008-06482-010
AU - Takahashi, Masaya
AU - Iwakiri, Kazuyuki
AU - Sotoyama, Midori
AU - Higuchi, Shigekazu
AU - Kiguchi, Masako
AU - Hirata, Mamoru
AU - Hisanaga, Naomi
AU - Kitahara, Teruyo
AU - Taoda, Kazushi
AU - Nishiyama, Katsuo
T1 - Work schedule differences in sleep problems of nursing home caregivers.
T3 - Contemporary research findings in shiftwork
JF - Applied Ergonomics
JO - Applied Ergonomics
JA - Appl Ergon
Y1 - 2008/09//
VL - 39
IS - 5
SP - 597
EP - 604
CY - Netherlands
PB - Elsevier Science
SN - 0003-6870
AD - Takahashi, Masaya, National Institute of Occupational Safety and Health, 6-21-1, Nagao, Tama-ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2008-06482-010. PMID: 18281013 Partial author list: First Author & Affiliation: Takahashi, Masaya; National Institute of Occupational Safety and Health, Kawasaki, Japan. Release Date: 20080908. Correction Date: 20160616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Caregivers; Sleep; Sleep Disorders; Work Scheduling; Working Conditions. Minor Descriptor: Nursing Homes. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Epworth Sleepiness Scale DOI: 10.1037/t07081-000; Pittsburgh Sleep Quality Index DOI: 10.1037/t05178-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Sep, 2008.
AB - Nursing home caregivers (n = 775; 604 women; mean age 33.6 years) were studied to examine how work schedules affect their sleep. The shift group (n = 536) worked under a rotating two-shift system (n = 365), a rotating three-shift system (n = 66), or other types of shifts (n = 78). The non-shift group included 222 caregivers. Participants completed a questionnaire about working conditions, sleep problems, health, lifestyle, and demographic factors. The two-shift caregivers reported the highest levels of difficulty initiating sleep (DIS, 37.6%), insomnia symptoms (43.0%), and poor quality of sleep (24.9%) among the groups. Adjusted odds ratios for these problems were significantly greater for the two-shift caregivers than for non-shift counterparts: DIS (odds ratio 2.86, 95% confidence interval 1.57-5.20), insomnia symptoms (2.33, 1.36-4.02), and poor sleep quality (2.15, 1.09-4.22). Our data suggest that working under a rotating two-shift system, which has a longer night shift, is associated with an elevated risk of sleep problems for nursing home caregivers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work schedule differences
KW - sleep problems
KW - nursing home caregivers
KW - working conditions
KW - quality of sleep
KW - 2008
KW - Caregivers
KW - Sleep
KW - Sleep Disorders
KW - Work Scheduling
KW - Working Conditions
KW - Nursing Homes
KW - 2008
DO - 10.1016/j.apergo.2008.01.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-06482-010&site=ehost-live&scope=site
UR - takaham@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12097-004
AN - 2008-12097-004
AU - McGrath, Patrick J.
AU - Walco, Gary A.
AU - Turk, Dennis C.
AU - Dworkin, Robert H.
AU - Brown, Mark T.
AU - Davidson, Karina
AU - Eccleston, Christopher
AU - Finley, G. Allen
AU - Goldschneider, Kenneth
AU - Haverkos, Lynne
AU - Hertz, Sharon H.
AU - Ljungman, Gustaf
AU - Palermo, Tonya
AU - Rappaport, Bob A.
AU - Rhodes, Thomas
AU - Schechter, Neil
AU - Scott, Jane
AU - Sethna, Navil
AU - Svensson, Ola K.
AU - Stinson, Jennifer
AU - von Baeyer, Carl L.
AU - Walker, Lynn
AU - Weisman, Steven
AU - White, Richard E.
AU - Zajicek, Anne
AU - Zeltzer, Lonnie
T1 - Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations.
JF - The Journal of Pain
JO - The Journal of Pain
JA - J Pain
Y1 - 2008/09//
VL - 9
IS - 9
SP - 771
EP - 783
CY - Netherlands
PB - Elsevier Science
SN - 1526-5900
AD - Walco, Gary A., Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, 30 Prospect Avenue, Hackensack, NJ, US, 07601
N1 - Accession Number: 2008-12097-004. PMID: 18562251 Partial author list: First Author & Affiliation: McGrath, Patrick J.; Dalhousie University, Halifax, NS, Canada. Release Date: 20090216. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Chronic Pain; Clinical Trials; Measurement; Pediatrics; Treatment Guidelines. Minor Descriptor: Clinicians; Decision Making; Relapse (Disorders). Classification: Medical Treatment of Physical Illness (3363); Professional Ethics & Standards & Liability (3450). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Tests & Measures: Parents Postoperative Pain Measures; FLACC Scale; Parent's Postoperative Pain Scale; Toddler-Preschooler Postoperative Pain Scale; Visual Analogue Scale; Children’s Hospital of Eastern Ontario Pain Scale DOI: 10.1037/t05366-000; COMFORT Scale DOI: 10.1037/t05367-000; Faces Pain Scale-Revised DOI: 10.1037/t05331-000. References Available: Y. Page Count: 13. Issue Publication Date: Sep, 2008.
AB - Under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT), 26 professionals from academia, governmental agencies, and the pharmaceutical industry participated in a 2-stage Delphi poll and a consensus meeting that identified core outcome domains and measures that should be considered in clinical trials of treatments for acute and chronic pain in children and adolescents. Consensus was refined by consultation with the international pediatric pain community through announcement of our recommendations on the Pediatric Pain List and inviting and incorporating comments from external sources. There was consensus that investigators conducting pediatric acute pain clinical trials should consider assessing outcomes in pain intensity; global judgment of satisfaction with treatment; symptoms and adverse events; physical recovery; emotional response; and economic factors. There was also agreement that investigators conducting pediatric clinical trials in chronic and recurrent pain should consider assessing outcomes in pain intensity; physical functioning; emotional functioning; role functioning; symptoms and adverse events; global judgment of satisfaction with treatment; sleep; and economic factors. Specific measures or measurement strategies were recommended for different age groups for each domain. Perspective: Based on systematic review and consensus of experts, core domains and measures for clinical trials to treat pain in children and adolescents were defined. This will assist in comparison and pooling of data and promote evidence-based treatment, encourage complete reporting of outcomes, simplify the review of proposals and manuscripts, and facilitate clinicians making informed decisions regarding treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - outcome domains
KW - pediatrics
KW - chronic pain
KW - acute pain
KW - recurrent pain
KW - clinical trials
KW - treatment recommendation
KW - informed decisions
KW - measurement
KW - 2008
KW - Chronic Pain
KW - Clinical Trials
KW - Measurement
KW - Pediatrics
KW - Treatment Guidelines
KW - Clinicians
KW - Decision Making
KW - Relapse (Disorders)
KW - 2008
U1 - Sponsor: AstraZeneca. Recipients: No recipient indicated
U1 - Sponsor: Endo Pharmaceuticals Inc.. Recipients: No recipient indicated
U1 - Sponsor: Merck and Co. Recipients: No recipient indicated
U1 - Sponsor: Pfizer. Other Details: University of Rochester. Recipients: No recipient indicated
DO - 10.1016/j.jpain.2008.04.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12097-004&site=ehost-live&scope=site
UR - ORCID: 0000-0001-9306-9450
UR - ORCID: 0000-0002-6308-1966
UR - ORCID: 0000-0002-4949-2494
UR - ORCID: 0000-0003-0698-1543
UR -
UR - gwalco@humed.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12794-005
AN - 2008-12794-005
AU - Zuvekas, Samuel H.
AU - Fleishman, John A.
T1 - Self-rated mental health and racial/ethnic disparities in mental health service use.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2008/09//
VL - 46
IS - 9
SP - 915
EP - 923
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Fleishman, John A., Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2008-12794-005. PMID: 18725845 Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20090727. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; Minority Groups; Racial and Ethnic Differences; Self-Report; Health Disparities. Minor Descriptor: Communities; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: SF-12; Self-Administered Questionnaire; Patient Health Questionnaire DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Sep, 2008.
AB - Background: Studies of health service use for emotional problems show that the majority of those with disorders do not seek professional help. In addition, mental health service use is lower among members of minority communities, compared with non-Hispanic whites. Objective: To examine the role of self-reported mental health as an indicator of awareness of mental conditions and as an influence in the process of seeking mental health care. Research Design: We conducted cross-sectional analyses of nationally representative data from the Medical Expenditure Panel Survey (MEPS) for 2000-2004. Measures: In-person interviews obtained data on self-rated mental health (SRMH), ambulatory mental health visits, and purchase of prescription medications to treat mental conditions. Respondents completed the SF-12 health status survey; analyses included the SF-12 mental component summary (MCS) as a measure of emotional symptoms. Analyses included only those who provided self-reports of MCS and SRMH. Results: SRMH was related to any ambulatory visit and any medication purchase for mental health treatment, controlling for MCS, and other sociodemographic and clinical variables. The association between SRMH and service use was weaker for black and Hispanic respondents than for whites. In addition, the magnitude of the association between SRMH and MCS was weaker for black and Hispanic respondents than for whites. Conclusions: Racial/ethnic differences in service use may arise in part from different propensities to interpret emotional symptoms as reflecting one's mental health and then to seek professional intervention for emotional problems. SRMH may be useful as an indicator of the extent to which people acknowledge the existence of emotional problems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self rated mental health
KW - racial & ethnic disparities
KW - mental health services
KW - minority communities
KW - emotional symptoms
KW - 2008
KW - Mental Health Services
KW - Minority Groups
KW - Racial and Ethnic Differences
KW - Self-Report
KW - Health Disparities
KW - Communities
KW - Mental Health
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality, US. Recipients: No recipient indicated
DO - 10.1097/MLR.0b013e31817919e5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12794-005&site=ehost-live&scope=site
UR - jfleishm@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-12283-004
AN - 2008-12283-004
AU - Pereira Do Carmo, Gail
AU - Polt, Robin
AU - Bilsky, Edward J.
AU - Rice, Kenner C.
AU - Negus, S. Stevens
T1 - Behavioral pharmacology of the μ/δ opioid glycopeptide MMP2200 in rhesus monkeys.
JF - The Journal of Pharmacology and Experimental Therapeutics
JO - The Journal of Pharmacology and Experimental Therapeutics
JA - J Pharmacol Exp Ther
Y1 - 2008/09//
VL - 326
IS - 3
SP - 939
EP - 948
CY - US
PB - American Society for Pharmacology & Experimental Therapeutics ASPET
SN - 0022-3565
SN - 1521-0103
AD - Negus, S. Stevens, Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N. 12th Street, PO Box 980613, Richmond, VA, US, 23298
N1 - Accession Number: 2008-12283-004. Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Pereira Do Carmo, Gail; Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA, US. Release Date: 20081201. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Narcotic Agonists; Neural Receptors; Opiates; Peptides; Pharmacokinetics. Minor Descriptor: Monkeys. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2008.
AB - H₂N-Tyr-D-Thr-Gly-Phe-Leu-Ser-(O-β-D-lactose)-CONH₂ (MMP2200) is a novel glycopeptide opioid agonist with similar affinities for μ and δ receptors. Glycosylation promoted brain penetration and production of centrally mediated behavioral effects in mice; however, it is unknown whether the magnitude of enhanced brain penetration is sufficient to permit central mediation of drug effects and production of synergistic μ/δ antinociceptive interactions after systemic administration in primates. To address this issue, the present study compared the effects of MMP2200 and the μ-agonist morphine in four behavioral procedures in rhesus monkeys. In an assay of thermal nociception, morphine (1.0-5.6 mg/kg) produced dose-dependent antinociception, whereas MMP2200 (10-56 mg/kg) was ineffective. In an assay of capsaicin-induced thermal allodynia, both morphine (0.01-1.0 mg/kg) and MMP2200 (0.032-3.2 mg/kg) produced dose-dependent antiallodynic effects. MMP2200-induced antiallodynia was blocked by the moderately μ-selective antagonist naltrexone (0.01 mg/kg), the δ-selective antagonist naltrindole (1.0 mg/kg), and the peripherally selective opioid antagonist quaternary naltrexone (0.32 mg/kg). In an assay of schedule-controlled behavior, both morphine (0.01-1.0 mg/kg) and MMP2200 (10-56 mg/kg) decreased response rates. Morphine effects were antagonized by naltrexone (0.001-0.01 mg/kg); however, the effects of MMP2200 were not antagonized by either naltrexone (0.01 mg/kg) or naltrindole (1.0 mg/kg). In an assay of drug self-administration, morphine (0.0032-0.32 mg/kg/injection) produced reinforcing effects, whereas MMP2200 (0.032-0.32 mg/kg/injection) did not. These results suggest that systemically administered MMP2200 acted as a peripheral, μ/δ-opioid agonist with limited distribution to the central nervous system in rhesus monkeys. These results also suggest the existence of species differences in the pharmacokinetics and brain penetration of glycopeptides. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral pharmacology
KW - mu/delta opioid glycopeptide
KW - rhesus monkeys
KW - neural receptors
KW - pharmacokinetics
KW - MMP2200
KW - glycopeptide opioid agonist
KW - 2008
KW - Narcotic Agonists
KW - Neural Receptors
KW - Opiates
KW - Peptides
KW - Pharmacokinetics
KW - Monkeys
KW - 2008
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R01-DA11460. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Neurological Disorders and Stroke. Grant: R01-NS052727. Recipients: No recipient indicated
U1 - Sponsor: Office of Naval Research. Grant: 14-05-1-0807; 14-05-1-0807. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, Intramural Research Programs, US. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Recipients: No recipient indicated
DO - 10.1124/jpet.108.138180
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-12283-004&site=ehost-live&scope=site
UR - ORCID: 0000-0002-4664-5256
UR -
UR - ssnegus@vcu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14971-018
AN - 2008-14971-018
AU - Luginbuhl, R. C.
AU - Jackson, L. L.
AU - Castillo, D. N.
AU - Loringer, K. A.
T1 - Heat-related deaths among crop workers—United States, 1992-2006.
JF - JAMA: Journal of the American Medical Association
JO - JAMA: Journal of the American Medical Association
JA - JAMA
Y1 - 2008/09//
VL - 300
IS - 9
SP - 1017
EP - 1018
CY - US
PB - American Medical Association
SN - 0098-7484
SN - 1538-3598
N1 - Accession Number: 2008-14971-018. Partial author list: First Author & Affiliation: Luginbuhl, R. C.; North Carolina Dept of Labor, NC, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Agricultural Workers; Death and Dying; Heat Effects; Stress; Stress Management. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Page Count: 2. Issue Publication Date: Sep, 2008.
AB - Workers employed in outdoor occupations such as farming are exposed to hot and humid environments that put them at risk for heat-related illness or death. This report describes one such death and summarizes heat-related fatalities among crop production workers in the United States during 1992- 2006. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - heat stress management
KW - crop workers
KW - heat-related deaths
KW - 2008
KW - Agricultural Workers
KW - Death and Dying
KW - Heat Effects
KW - Stress
KW - Stress Management
KW - 2008
DO - 10.1001/jama.300.9.1017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14971-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-13322-006
AN - 2008-13322-006
AU - Gaughan, Denise M.
AU - Cox-Ganser, Jean M.
AU - Enright, Paul L.
AU - Castellan, Robert M.
AU - Wagner, Gregory R.
AU - Hobbs, Gerald R.
AU - Bledsoe, Toni A.
AU - Siegel, Paul D.
AU - Kreiss, Kathleen
AU - Weissman, David N.
T1 - Acute upper and lower respiratory effects in wildland firefighters.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2008/09//
VL - 50
IS - 9
SP - 1019
EP - 1028
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - Gaughan, Denise M., NIOSH, MS-H2800, 1095 Willowdale Road, Morgantown, WV, US, 26505
N1 - Accession Number: 2008-13322-006. PMID: 18784550 Partial author list: First Author & Affiliation: Gaughan, Denise M.; National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, US. Release Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Fire Fighters; Occupational Exposure; Respiration. Classification: Police & Legal Personnel (4290); Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: American Thoracic Society Adult Respiratory Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2008.
AB - Objectives: To assess acute respiratory effects experienced by wildl and firefighters. Methods: We studied two Interagency Hotshot Crews with questionnaires, spirometry, and measurement of albumin, eosinophilic cationic protein (ECP), and myeloperoxidase (MPO) as indicators of inflammation in sputum and nasal lavage fluid. Assessments were made preseason, postfire, and postseason. Results: Fifty-eight members of the two crews had at least two assessments. Mean upper and lower respiratory symptom scores were higher postfire compared to preseason (P < 0.001). The mean forced expiratory volume in 1 second was lower postfire compared to preseason (P < 0.001) and then recovered by postseason. Individual increases in sputum and nasal ECP and MPO from preseason to postfire were all significantly associated with postfire respiratory symptom scores. Conclusions: Wildland firefighting was associated with upper and lower respiratory symptoms and reduced forced expiratory volume in 1 second. Within individuals, symptoms were associated with increased ECP and MPO in sputum and nasal lavage fluid. The long-term respiratory health impact of wildland firefighting, especially over multiple fire seasons, remains an important concern. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - acute upper respiratory effects
KW - acute lower respiratory effects
KW - wildland firefighters
KW - 2008
KW - Fire Fighters
KW - Occupational Exposure
KW - Respiration
KW - 2008
DO - 10.1097/JOM.0b013e3181754161
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13322-006&site=ehost-live&scope=site
UR - dug5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-09271-019
AN - 2008-09271-019
AU - Ashley, Olivia Silber
AU - Penne, Michael A.
AU - Loomis, Kellie M.
AU - Kan, Marni
AU - Bauman, Karl E.
AU - Aldridge, Molly
AU - Gfroerer, Joseph C.
AU - Novak, Scott P.
T1 - Moderation of the association between parent and adolescent cigarette smoking by selected sociodemographic variables.
JF - Addictive Behaviors
JO - Addictive Behaviors
JA - Addict Behav
Y1 - 2008/09//
VL - 33
IS - 9
SP - 1227
EP - 1230
CY - Netherlands
PB - Elsevier Science
SN - 0306-4603
AD - Ashley, Olivia Silber, RTI International, Post Office Box 12194, Research Triangle Park, NC, US, 27709-2194
N1 - Accession Number: 2008-09271-019. PMID: 18555618 Partial author list: First Author & Affiliation: Ashley, Olivia Silber; RTI International, Research Triangle Park, NC, US. Release Date: 20080825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Demographic Characteristics; Parental Characteristics; Tobacco Smoking. Minor Descriptor: Fathers; Mothers. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Sep, 2008.
AB - This study examines variation in the associations between cigarette smoking by mother or father and adolescent cigarette smoking by selected sociodemographic characteristics. The study data are from nationally representative samples of adolescents aged 12 to 17 living with their mothers (n = 4734) and/or fathers (n = 3176). Mother cigarette smoking was more strongly associated with cigarette smoking by daughters than sons. The association between father cigarette smoking and adolescent cigarette smoking did not vary by adolescent gender. The association between mother or father cigarette smoking and adolescent cigarette smoking did not vary by parent's education, family structure, or adolescent age or race/ethnicity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent cigarette smoking
KW - parent cigarette smoking
KW - fathers
KW - mothers
KW - sociodemographic variables
KW - 2008
KW - Adolescent Development
KW - Demographic Characteristics
KW - Parental Characteristics
KW - Tobacco Smoking
KW - Fathers
KW - Mothers
KW - 2008
DO - 10.1016/j.addbeh.2008.04.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-09271-019&site=ehost-live&scope=site
UR - osilber@rti.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-11385-008
AN - 2008-11385-008
AU - Druss, Benjamin G.
AU - Bornemann, Thomas
AU - Fry-Johnson, Yvonne W.
AU - McCombs, Harriet G.
AU - Politzer, Robert M.
AU - Rust, George
T1 - Trends in mental health and substance abuse services at the nation's community health centers: 1998-2003.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/09//
VL - 98
IS - Suppl9
SP - S126
EP - S131
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Druss, Benjamin G., 1518 Clifton Rd, Atlanta, GA, US, 30322
N1 - Accession Number: 2008-11385-008. Partial author list: First Author & Affiliation: Druss, Benjamin G.; Rollins School of Public Health, Emory University, Atlanta, GA, US. Release Date: 20090706. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article; Reprint. Language: English. Major Descriptor: Community Mental Health Centers; Community Mental Health Services; Drug Abuse; Trends. Minor Descriptor: Community Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 2008.
AB - Objective: We examined trends in delivery of mental health and substance abuse services at the nation’s community health centers. Methods: Analyses used data from the Health Resources and Services Administration (HRSA), Bureau of Primary Care’s (BPHC) 1998 and 2003 Uniform Data System, merged with county-level data. Results: Between 1998 and 2003, the number of patients diagnosed with a mental health/substance abuse disorder in community health centers increased from 210 000 to 800 000. There was an increase in the number of patients per specialty mental health/substance abuse treatment provider and a decline in the mean number of patient visits, from 7.3 visits per patient to 3.5 by 2003. Although most community health centers had some on-site mental health/substance abuse services, centers without on-site services were more likely to be located in counties with fewer mental health/substance abuse clinicians, psychiatric emergency rooms, and inpatient hospitals. Conclusions: Community health centers are playing an increasingly central role in providing mental health/substance abuse treatment services in the United States. It is critical both to ensure that these centers have adequate resources for providing mental health/substance abuse care and that they develop effective linkages with mental health/substance abuse clinicians in the communities they serve. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trends
KW - mental health
KW - substance abuse services
KW - nations community health centers
KW - mental health delivery
KW - 2008
KW - Community Mental Health Centers
KW - Community Mental Health Services
KW - Drug Abuse
KW - Trends
KW - Community Health
KW - 2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-11385-008&site=ehost-live&scope=site
UR - bdruss@emory.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cobb, Nathaniel
AU - Wingo, Phyllis A.
AU - Edwards, Brenda K.
T1 - Introduction to the Supplement on Cancer in the American Indian and Alaska Native Populations in the United States.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - Article
SP - 1113
EP - 1116
SN - 0008543X
AB - The article focuses on a Supplement on cancer in American Indians and Alaska Natives from 1999 to 2004. It states that the collection of papers in this Supplement combines cancer incidence data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results program, intensified by record linkages and geographic factors. It also aims to provide a complete description of the cancer burden in the American Indian and Alaska Native population in the U.S.
KW - INDIGENOUS peoples of the Americas
KW - CANCER
KW - EPIDEMIOLOGY
KW - POPULATION
KW - ALASKA
KW - UNITED States
KW - Alaska Native
KW - American Indian
KW - cancer incidence
KW - disparities
KW - misclassification
KW - race
N1 - Accession Number: 34309289; Cobb, Nathaniel 1; Email Address: nathaniel.cobb@ihs.gov Wingo, Phyllis A. 2 Edwards, Brenda K. 3; Affiliation: 1: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico 2: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1113; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: CANCER; Subject Term: EPIDEMIOLOGY; Subject Term: POPULATION; Subject Term: ALASKA; Subject Term: UNITED States; Author-Supplied Keyword: Alaska Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: cancer incidence; Author-Supplied Keyword: disparities; Author-Supplied Keyword: misclassification; Author-Supplied Keyword: race; Number of Pages: 4p; Document Type: Article
L3 - 10.1002/cncr:23729
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309289&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weir, Hannah K.
AU - Jim, Melissa A.
AU - Marrett, Loraine D.
AU - Fairley, Temeika
T1 - Cancer in American Indian and Alaska Native Young Adults (Ages 20-44 Years): US, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - Article
SP - 1153
EP - 1167
SN - 0008543X
AB - The article presents a study on the cancer incidence patterns in American Indians and Alaska Native (AI/AN) young adults, ages 20 to 44 years, in the U.S. from 1999 through 2004. It states that age-adjusted cancer incidence rates per 100,000 (AAR) and corresponding rate ratios (RR) for young adults were compared across IHS regions and for chosen cancers within Contract Health Service Delivery Area counties by race, which is AI/AN versus non-Hispanic whites (NHW), and sex.
KW - CANCER -- Diagnosis
KW - CANCER research
KW - INDIGENOUS peoples of the Americas
KW - YOUNG adults
KW - RACE
KW - HUMAN sexuality
KW - PUBLIC health research
KW - UNITED States
KW - Alaskan Native
KW - American Indian
KW - cancer
KW - End Results (SEER)
KW - Epidemiology
KW - incidence
KW - National Program of Cancer Registries (NPCR)
KW - Surveillance
N1 - Accession Number: 34309294; Weir, Hannah K. 1; Email Address: hbw4@cdc.gov Jim, Melissa A. 1,2 Marrett, Loraine D. 3 Fairley, Temeika 1; Affiliation: 1: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico 3: Division of Preventive Oncology, Cancer Care Ontario, Toronto, Ontario, Canada; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1153; Subject Term: CANCER -- Diagnosis; Subject Term: CANCER research; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: YOUNG adults; Subject Term: RACE; Subject Term: HUMAN sexuality; Subject Term: PUBLIC health research; Subject Term: UNITED States; Author-Supplied Keyword: Alaskan Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: cancer; Author-Supplied Keyword: End Results (SEER); Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: incidence; Author-Supplied Keyword: National Program of Cancer Registries (NPCR); Author-Supplied Keyword: Surveillance; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 15p; Illustrations: 2 Charts, 1 Graph, 1 Map; Document Type: Article
L3 - 10.1002/cncr.23731
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309294&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bliss, Anne
AU - Cobb, Nathaniel
AU - Solomon, Teshia
AU - Cravatt, Kym
AU - Jim, Melissa A.
AU - Marshall, Lalisha
AU - Campbell, Janis
T1 - Lung Cancer Incidence Among American Indians and Alaska Natives in the United States, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - Article
SP - 1168
EP - 1178
SN - 0008543X
AB - The article presents a study on lung cancer incidence among American Indians and Alaska Natives (AI/ANs) in the U.S. from 1999 to 2004. It states that data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program were combined to calculate age-adjusted incidence rates of lung cancer during 1999 through 2004.
KW - LUNGS -- Cancer
KW - INDIGENOUS peoples of the Americas
KW - EPIDEMIOLOGY
KW - CANCER research
KW - PUBLIC health research
KW - ALASKA
KW - UNITED States
KW - Alaska Native
KW - American Indian
KW - and End Results
KW - cancer
KW - Epidemiology
KW - health disparity
KW - incidence
KW - misclassification
KW - National Program of Cancer Registries
KW - Surveillance
KW - United States
N1 - Accession Number: 34309295; Bliss, Anne 1 Cobb, Nathaniel 2; Email Address: nathaniel.cobb@ihs.gov Solomon, Teshia 3 Cravatt, Kym 4 Jim, Melissa A. 5,6 Marshall, Lalisha 7 Campbell, Janis 1; Affiliation: 1: Chronic Disease Services, Oklahoma State Department of Health, Oklahoma City, Oklahoma 2: Indian Health Service, Division of Epidemiology and Disease Prevention, Albuquerque, New Mexico 3: Native American Research and Training Center, Department of Family and Community Medicine, University of Arizona, Tucson, Arizona 4: Cancer Prevention and Control, Cherokee Nation, Tahlequah, Oklahoma 5: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Albuquerque, New Mexico 6: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico 7: Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1168; Subject Term: LUNGS -- Cancer; Subject Term: INDIGENOUS peoples of the Americas; Subject Term: EPIDEMIOLOGY; Subject Term: CANCER research; Subject Term: PUBLIC health research; Subject Term: ALASKA; Subject Term: UNITED States; Author-Supplied Keyword: Alaska Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: and End Results; Author-Supplied Keyword: cancer; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: health disparity; Author-Supplied Keyword: incidence; Author-Supplied Keyword: misclassification; Author-Supplied Keyword: National Program of Cancer Registries; Author-Supplied Keyword: Surveillance; Author-Supplied Keyword: United States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 11p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1002/cncr.23738
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309295&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Taylor Wilson, Robin
AU - Richardson, Lisa C.
AU - Kelly, Janet J.
AU - Kaur, Judith
AU - Jim, Melissa A.
AU - Lanier, Anne P.
AU - Wilson, Robin Taylor
T1 - Cancers of the urinary tract among American Indians and Alaska Natives in the United States, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - journal article
SP - 1213
EP - 1224
SN - 0008543X
AB - Background: Assessment of the kidney parenchyma ("kidney") and urinary bladder ("bladder") cancer burden among American Indians and Alaska Natives (AI/AN) has been limited. Using a database with improved classification for AI/AN, the authors described patterns of these 2 cancers among AI/AN and non-Hispanic whites (NHW) in the United States.Methods: Cases diagnosed during 1999 to 2004 were identified through National Program of Cancer Registries and the Surveillance, Epidemiology and End Results program and linked to the Indian Health Service (IHS) registration records. Age-adjusted incidence rates, rate ratios (RR), annual percent change, and stage at diagnosis were stratified by IHS Contract Health Service Delivery Area (CHSDA) counties to adjust for misclassification.Results: Kidney cancer incidence among AI/AN in CHSDA counties exceeded that among NHW (RR, 1.51; 95% confidence interval [CI], 1.42-1.61), and was highest among AI/AN in the Northern Plains, Southern Plains, Alaska, and Southwest. Average annual increases were highest among AI/AN (5.9%) and NHW (5.9%) males aged 20 to 49 years, although statistically significant only among NHW. Conversely, bladder cancer incidence was significantly lower among AI/AN than NHW (RR, 0.40; 95% CI, 0.37-0.44). For both sites, AI/AN were significantly less likely to be diagnosed at an earlier stage than NHW.Conclusions: AI/AN have about 50% greater risk of kidney cancer and half the risk of bladder cancer than NHW. Although reasons for these enigmatic patterns are not known, sustained primary prevention efforts through tobacco cessation and obesity prevention are warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer (0008543X) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - URINARY organs -- Cancer
KW - DISEASE prevalence
KW - INDIGENOUS peoples
KW - DISEASES
KW - CANCER
KW - INDIGENOUS peoples of the Americas
KW - Alaska Native
KW - American Indian
KW - cancer
KW - health disparity
KW - incidence
KW - misclassification
KW - NPCR
KW - SEER
KW - United States
N1 - Accession Number: 34309299; Taylor Wilson, Robin 1; Email Address: rwilson@psu.edu Richardson, Lisa C. 2 Kelly, Janet J. 3 Kaur, Judith 4 Jim, Melissa A. 2,5 Lanier, Anne P. 3 Wilson, Robin Taylor 6; Affiliation: 1: Division of Epidemiology, Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 2: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Alaska Native Tribal Health Consortium, Anchorage, Alaska 4: Department of Oncology, Mayo Clinic, Rochester, Minnesota 5: Division of Epidemiology and Disease Prevention, Indian Health Service, Alburquerque, New Mexico 6: Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1213; Subject Term: URINARY organs -- Cancer; Subject Term: DISEASE prevalence; Subject Term: INDIGENOUS peoples; Subject Term: DISEASES; Subject Term: CANCER; Subject Term: INDIGENOUS peoples of the Americas; Author-Supplied Keyword: Alaska Native; Author-Supplied Keyword: American Indian; Author-Supplied Keyword: cancer; Author-Supplied Keyword: health disparity; Author-Supplied Keyword: incidence; Author-Supplied Keyword: misclassification; Author-Supplied Keyword: NPCR; Author-Supplied Keyword: SEER; Author-Supplied Keyword: United States; Number of Pages: 12p; Illustrations: 6 Charts, 1 Map; Document Type: journal article
L3 - 10.1002/cncr.23733
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309299&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jim, Melissa A.
AU - Perdue, David G.
AU - Richardson, Lisa C.
AU - Espey, David K.
AU - Redd, John T.
AU - Martin, Howard J.
AU - Kwong, Sandy L.
AU - Kelly, Janet J.
AU - Henderson, Jeffrey A.
AU - Ahmed, Faruque
T1 - Primary liver cancer incidence among American Indians and Alaska Natives, US, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - journal article
SP - 1244
EP - 1255
SN - 0008543X
AB - Background: American Indians and Alaska Natives (AI/AN) experience higher morbidity and mortality from primary liver cancer than other United States (US) populations, but racial misclassification in medical records results in underestimates of disease burden.Methods: To reduce misclassification, National Program of Cancer Registries and Surveillance, Epidemiology, and End Results data were linked with Indian Health Service (IHS) enrollment records to compare primary liver cancer incidence and stage at diagnosis between AI/AN and non-Hispanic whites (NHW) living within the regionalized IHS Contract Health Service Delivery Area counties. Incidence rates are expressed per 100,000 persons and age-adjusted by 19 age groups to the 2000 US standard population.Results: Overall, AI/AN have a higher proportion of hepatocellular carcinoma compared with NHW, 77.8% versus 66.7%. Liver cancer incidence rates among AI/AN males and females were higher than those among NHW males and females for all regions except for the East. Among males, rates ranged from 7.3 (95% confidence interval [CI], 3.8-12.6) in the East to 17.2 (95% CI, 10.4-26.3) in Alaska. Among females, rates ranged from 3.8 (95% CI, 1.4-8.2) in the East to 6.9 (95% CI, 3.6-11.6) in Alaska. The AI/AN rates for all regions were consistently higher than the NHW rates at every age. An increasing trend among AI/AN was suggested but did not achieve statistical significance.Conclusions: Reducing racial misclassification revealed higher disparities in primary liver cancer incidence between NHW and AI/AN populations than previously reported. Further description of the reasons for regional differences in this disparity is needed, as are programs to reduce risk factors and to diagnose primary liver cancer at earlier, more treatable stages. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer (0008543X) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Cancer
KW - DISEASE prevalence
KW - INDIGENOUS peoples
KW - DISEASES
KW - CANCER
KW - INDIGENOUS peoples of the Americas
N1 - Accession Number: 34309302; Jim, Melissa A. 1,2; Email Address: melissa.jim@ihs.gov Perdue, David G. 3,4 Richardson, Lisa C. 1 Espey, David K. 1,2 Redd, John T. 2,5 Martin, Howard J. 6 Kwong, Sandy L. 7 Kelly, Janet J. 8 Henderson, Jeffrey A. 9 Ahmed, Faruque 10; Affiliation: 1: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 2: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico 3: Division of Gastroenterology and Hepatology, Cancer Center, and Program in Health Disparities Research, University of Minnesota, Minneapolis, Minnesota 4: Minnesota Gastroenterology, PA., Minneapolis, Minnesota 5: Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia 6: Virginia Cancer Registry, Office of Family Health Services, Virginia Department of Health, Richmond, Virginia 7: Cancer Surveillance Section, California Department of Public Health, Sacramento, California 8: Office of Alaska Native Health Research, Alaska Native Epidemiology Center, Alaska Native Tribal Health Consortium, Anchorage, Alaska 9: Black Hills Center for American Indian Health, Rapid City, South Dakota 10: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1244; Subject Term: LIVER -- Cancer; Subject Term: DISEASE prevalence; Subject Term: INDIGENOUS peoples; Subject Term: DISEASES; Subject Term: CANCER; Subject Term: INDIGENOUS peoples of the Americas; Number of Pages: 12p; Illustrations: 5 Charts, 2 Graphs; Document Type: journal article
L3 - 10.1002/cncr.23728
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309302&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reichman, Marsha E.
AU - Kelly, Janet J.
AU - Kosary, Carol L.
AU - Coughlin, Steven S.
AU - Jim, Melissa A.
AU - Lanier, Anne P.
T1 - Incidence of Cancers of the Oral Cavity and Pharynx Among American Indians and Alaska Natives, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - Article
SP - 1256
EP - 1265
SN - 0008543X
AB - The article presents a study about the incidence of cancers of the oral cavity and pharynx among American Indians and Alaska Natives (AI/AN) in the U.S. in 1999-2004. Data from U.S. central cancer registries and the Indian Health Service (IHS) records were linked to compare the incidence rates between AI/AN and non-Hispanic white (NHW) populations.
KW - ORAL cancer
KW - PHARYNGEAL cancer
KW - DISEASE prevalence
KW - INDIGENOUS peoples
KW - DISEASES
KW - CANCER
KW - INDIGENOUS peoples of the Americas
KW - American Indian/Alaska Native
KW - cancer
KW - incidence
KW - NPCR
KW - oral cavity
KW - pharynx
KW - SEER
N1 - Accession Number: 34309303; Reichman, Marsha E. 1; Email Address: ReichmaM@mail.nih.gov Kelly, Janet J. 2 Kosary, Carol L. 1 Coughlin, Steven S. 3 Jim, Melissa A. 3,4 Lanier, Anne P. 2; Affiliation: 1: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 2: Alaska Native Epidemiology Center, Alaska Native Tribal Health Consortium, Anchorage, Alaska 3: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 4: Division of Epidemiology and Disease Prevention, Indian Health Service, Albuquerque, New Mexico; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1256; Subject Term: ORAL cancer; Subject Term: PHARYNGEAL cancer; Subject Term: DISEASE prevalence; Subject Term: INDIGENOUS peoples; Subject Term: DISEASES; Subject Term: CANCER; Subject Term: INDIGENOUS peoples of the Americas; Author-Supplied Keyword: American Indian/Alaska Native; Author-Supplied Keyword: cancer; Author-Supplied Keyword: incidence; Author-Supplied Keyword: NPCR; Author-Supplied Keyword: oral cavity; Author-Supplied Keyword: pharynx; Author-Supplied Keyword: SEER; Number of Pages: 10p; Illustrations: 4 Charts, 1 Map; Document Type: Article
L3 - 10.1002/cncr.23735
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309303&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lemrow, Shannon M.
AU - Perdue, David G.
AU - Stewart, Sherri L.
AU - Richardson, Lisa C.
AU - Jim, Melissa A.
AU - French, Helen T.
AU - Swan, Judith
AU - Edwards, Brenda K.
AU - Wiggins, Charles
AU - Dickie, Lois
AU - Espey, David K.
T1 - Gallbladder Cancer Incidence Among American Indians and Alaska Natives, US, 1999-2004.
JO - Cancer (0008543X)
JF - Cancer (0008543X)
Y1 - 2008/09/02/Sep2008 Supplement
VL - 113
IS - 5
M3 - Article
SP - 1266
EP - 1273
SN - 0008543X
AB - The article presents a study about the incidence of gallbladder cancer (GBC) among American Indians and Alaska Natives (AI/AN) in the U.S. in 1999-2004. Cancer registry records and Indian Health Service (IHS) administration records were linked to compare incidence rates between AI/AN and non-Hispanic whites (NHW).
KW - GALLBLADDER -- Cancer
KW - DISEASE prevalence
KW - INDIGENOUS peoples
KW - DISEASES
KW - CANCER
KW - INDIGENOUS peoples of the Americas
KW - American Indian/Alaska Native
KW - distant stage
KW - gallbladder cancer
KW - regional stage
KW - surveillance
N1 - Accession Number: 34309304; Lemrow, Shannon M. 1 Perdue, David G. 2,3 Stewart, Sherri L. 4; Email Address: sstewart2@cdc.gov Richardson, Lisa C. 4 Jim, Melissa A. 4,5 French, Helen T. 1 Swan, Judith 1 Edwards, Brenda K. 1 Wiggins, Charles 6 Dickie, Lois 1 Espey, David K. 4,5; Affiliation: 1: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 2: Division of Gastroenterology and Hepatology, Cancer Center, and Program in Health Disparities Research, University of Minnesota, Minneapolis, Minnesota 3: Minnesota Gasteroenterology, PA., Minneapolis, Minnesota 4: Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Con- trol and Prevention, Atlanta, Georgia 5: Division of Epidemiology and Disease Prevention, Indian Health Service (IHS), Albuquerque, New Mexico 6: New Mexico Tumor Registry, University of New Mexico Cancer Center, Albuquerque, New Mexico; Source Info: Sep2008 Supplement, Vol. 113 Issue 5, p1266; Subject Term: GALLBLADDER -- Cancer; Subject Term: DISEASE prevalence; Subject Term: INDIGENOUS peoples; Subject Term: DISEASES; Subject Term: CANCER; Subject Term: INDIGENOUS peoples of the Americas; Author-Supplied Keyword: American Indian/Alaska Native; Author-Supplied Keyword: distant stage; Author-Supplied Keyword: gallbladder cancer; Author-Supplied Keyword: regional stage; Author-Supplied Keyword: surveillance; Number of Pages: 8p; Illustrations: 3 Charts, 1 Map; Document Type: Article
L3 - 10.1002/cncr.23737
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34309304&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Selden, Thomas M.
AU - Sing, Merrile
T1 - The Distribution Of Public Spending For Health Care In The United States, 2002.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/09/02/Sep/Oct2008 Web Exclusives
VL - 27
IS - 5
M3 - Article
SP - w349
EP - w359
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - U.S. health care spending is projected to approach $2.4 trillion in 2008; a large share will be paid by government outlays and tax subsidies. Other countries routinely conduct incidence analyses of public health care spending, yet we know of no recent and comprehensive incidence studies for the United States. We examined data for 2002 from the Medical Expenditure Panel Survey aligned to the National Health Expenditure Accounts and augmented with simulated tax subsidies. The public sector accounted for 56.1 percent of health spending within the civilian noninstitutionalized population. Our analysis highlights this sector's role in financing the care of seniors and people in poor health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC spending
KW - MEDICAL care -- United States
KW - MEDICAL care -- Finance
KW - GOVERNMENT policy
KW - MEDICAL care costs
KW - PUBLIC health -- Finance
KW - MEDICAL policy
KW - NATIONAL health services
KW - TAX expenditures
KW - UNITED States
N1 - Accession Number: 34409459; Selden, Thomas M. 1; Email Address: tselden@ahrq.gov Sing, Merrile 1; Affiliation: 1: theCenter for Financing,Access, and Cost Trends,Agency for Healthcare Research and Quality (AHRQ), in Rockville,Maryland; Source Info: Sep/Oct2008 Web Exclusives, Vol. 27 Issue 5, pw349; Subject Term: PUBLIC spending; Subject Term: MEDICAL care -- United States; Subject Term: MEDICAL care -- Finance; Subject Term: GOVERNMENT policy; Subject Term: MEDICAL care costs; Subject Term: PUBLIC health -- Finance; Subject Term: MEDICAL policy; Subject Term: NATIONAL health services; Subject Term: TAX expenditures; Subject Term: UNITED States; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.27.5.w349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34409459&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Selden, Thomas M.
AU - Sing, Merrile
T1 - The Distribution Of Public Spending For Health Care In The United States, 2002.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/09/02/Sep/Oct2008 Web Exclusives
VL - 27
IS - 5
M3 - Article
SP - w349
EP - w359
SN - 02782715
AB - U.S. health care spending is projected to approach $2.4 trillion in 2008; a large share will be paid by government outlays and tax subsidies. Other countries routinely conduct incidence analyses of public health care spending, yet we know of no recent and comprehensive incidence studies for the United States. We examined data for 2002 from the Medical Expenditure Panel Survey aligned to the National Health Expenditure Accounts and augmented with simulated tax subsidies. The public sector accounted for 56.1 percent of health spending within the civilian noninstitutionalized population. Our analysis highlights this sector's role in financing the care of seniors and people in poor health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC spending
KW - MEDICAL care
KW - MEDICAL care -- Finance
KW - GOVERNMENT policy
KW - FINANCE
KW - TAX expenditures
KW - MEDICAL care costs
KW - PUBLIC health
KW - MEDICAL policy
KW - NATIONAL health services
KW - UNITED States
N1 - Accession Number: 34409459; Selden, Thomas M. 1; Email Address: tselden@ahrq.gov; Sing, Merrile 1; Affiliations: 1: theCenter for Financing,Access, and Cost Trends,Agency for Healthcare Research and Quality (AHRQ), in Rockville,Maryland; Issue Info: Sep/Oct2008 Web Exclusives, Vol. 27 Issue 5, pw349; Thesaurus Term: PUBLIC spending; Thesaurus Term: MEDICAL care; Thesaurus Term: MEDICAL care -- Finance; Thesaurus Term: GOVERNMENT policy; Thesaurus Term: FINANCE; Thesaurus Term: TAX expenditures; Subject Term: MEDICAL care costs; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: NATIONAL health services; Subject: UNITED States; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.27.5.w349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=34409459&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hung, Tran Manh
AU - Na, MinKyun
AU - Dat, Nguyen Tien
AU - Ngoc, Tran Minh
AU - Youn, UiJoung
AU - Kim, Hong Jin
AU - Min, Byung-Sun
AU - Lee, JongPill
AU - Bae, KiHwan
T1 - Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2008/09/02/
VL - 119
IS - 1
M3 - Article
SP - 74
EP - 80
SN - 03788741
AB - Abstract: In the course of screening plants used in Korean folk medicine as memory enhancers, a 70% ethanol extract of tuber from Corydalis turtschaninovii Besser (Papaveraceae) showed significant acetylcholinesterase (AChE) inhibitory activity. Repeated column chromatography led to the isolation of a new aporphine alkaloid, oxoglaucidaline (9), and a new protoberberine, pseudodehydrocorydaline (13) together with 14 known compounds (1–8, 10–12, and 14–16). The chemical structures of isolated compounds were elucidated base on extensive 1D and 2D NMR spectroscopic data. Compounds 1–16 were investigated in vitro for their anti-cholinesterase activity using the mice cortex AChE enzyme. In further study, the anti-amnesic activities of pseudoberberine (16) in mice on the learning and memory impairments induced by scopolamine (1.0mg/kg, i.p.) were examined. This alkaloid (5.0mg/kg, p.o.) administration significantly reversed cognitive impairments in mice by passive avoidance test (P <0.05). It also reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P <0.05). These results indicated that Corydalis turtschaninovii due to its alkaloids have anti-cholinesterase activity and pseudoberberine and other alkaloids have anti-amnesic activities that may be useful for cognitive impairment treatment. [Copyright &y& Elsevier]
AB - Copyright of Journal of Ethnopharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHOLINESTERASES
KW - ALKALOIDS
KW - TRADITIONAL medicine
KW - MEDICINAL plants
KW - Acetylcholinesterase
KW - Amnesic
KW - Corydalis turtschaninovii
KW - Oxoglaucidaline
KW - Pseudoberberine
KW - Pseudodehydrocorydaline
N1 - Accession Number: 33887286; Hung, Tran Manh 1 Na, MinKyun 1 Dat, Nguyen Tien 1 Ngoc, Tran Minh 1 Youn, UiJoung 1 Kim, Hong Jin 1 Min, Byung-Sun 2 Lee, JongPill 3 Bae, KiHwan 1; Email Address: baekh@cnu.ac.kr; Affiliation: 1: College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea 2: College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea 3: Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Sep2008, Vol. 119 Issue 1, p74; Subject Term: CHOLINESTERASES; Subject Term: ALKALOIDS; Subject Term: TRADITIONAL medicine; Subject Term: MEDICINAL plants; Author-Supplied Keyword: Acetylcholinesterase; Author-Supplied Keyword: Amnesic; Author-Supplied Keyword: Corydalis turtschaninovii; Author-Supplied Keyword: Oxoglaucidaline; Author-Supplied Keyword: Pseudoberberine; Author-Supplied Keyword: Pseudodehydrocorydaline; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jep.2008.05.041
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33887286&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105966562
T1 - Practice-based research networks: laboratories for improving colorectal cancer screening in primary care practice.
AU - Lanier D
Y1 - 2008/09/02/2008 Sep Supplement 1
N1 - Accession Number: 105966562. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: 2008 Sep Supplement 1. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care. NLM UID: 0230027.
KW - Cancer Screening -- Trends
KW - Colorectal Neoplasms -- Diagnosis
KW - Primary Health Care -- Trends
KW - Professional Practice, Research-Based
KW - Multimethod Studies
KW - Observational Methods
KW - Qualitative Studies
KW - Secondary Analysis
KW - Surveys
SP - S147
EP - 52
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 46
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0025-7079
AD - Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 18725827.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Mancuso, James D.
AU - Krauss, Margot R.
AU - Audet, Susette
AU - Beeler, Judy A.
T1 - ELISA underestimates measles antibody seroprevalence in US military recruits
JO - Vaccine
JF - Vaccine
Y1 - 2008/09/08/
VL - 26
IS - 38
M3 - Letter
SP - 4877
EP - 4878
SN - 0264410X
AB - Abstract: The prevalence of antibodies to measles, mumps, and rubella in US military recruits is of importance to public health leaders. We performed ELISA testing using a commercially available product on samples from 537 recruits obtained in 1998, of which 437 were positive (81%). We then performed a validation study in a subsample of the population using plaque reduction neutralization (PRN) to assess misclassification error. This resulted in a corrected estimate of the prevalence of immunity to measles of 96% (95% CI: 92–100%). The military vaccinates a percentage of recruits who are likely to be immune if more sensitive testing, such as PRN, was used. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - Public health
KW - Immunoglobulins
KW - United States
KW - Immunizations
KW - Measles epidemiology
KW - Military personnel
KW - Seroepidemiology
N1 - Accession Number: 34092427; Mancuso, James D. 1; Email Address: james.mancuso@us.army.mil; Krauss, Margot R. 2; Audet, Susette 3; Beeler, Judy A. 3; Affiliations: 1: Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, United States; 2: Westat, Rockville, MD, United States; 3: Division of Viral Products, Center for Biologics Evaluation and Research, FDA, United States; Issue Info: Sep2008, Vol. 26 Issue 38, p4877; Thesaurus Term: Virus diseases; Thesaurus Term: Public health; Subject Term: Immunoglobulins; Subject: United States; Author-Supplied Keyword: Immunizations; Author-Supplied Keyword: Measles epidemiology; Author-Supplied Keyword: Military personnel; Author-Supplied Keyword: Seroepidemiology; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.vaccine.2008.06.028
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ellison, Christopher D.
AU - Ennis, Bryan J.
AU - Hamad, Mazen L.
AU - Lyon, Robbe C.
T1 - Measuring the distribution of density and tabletting force in pharmaceutical tablets by chemical imaging
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/09/10/
VL - 48
IS - 1
M3 - Article
SP - 1
EP - 7
SN - 07317085
AB - Abstract: In pharmaceutical processing, the lubricant magnesium stearate (MgS) can affect compaction efficiency based on blend time and amount of MgS used. Insufficient lubrication produces intra-tablet variations in density. Consistent tablet density profiles and uniform compaction force, as managed by proper lubrication, are important for predictable performance. The current work demonstrates the utility of near-infrared (NIR) chemical imaging in measuring density variations within compacts, and relates these variations to tabletting forces as controlled by frictional properties and quantity of MgS. Lactose monohydrate was blended with 0%, 0.25%, or 1.0% MgS for 30s or 30min. Compacts were prepared of each blend, with compaction forces monitored by load cells. Frictional properties were measured by automated shear cell. NIR chemical images were collected for each tablet, and the density at each image pixel was calculated. Density distribution within compacts was well perceived within the NIR images. Uniformity of intra-tablet density was strongly dependent upon friction between powder and die walls: tablets with no MgS or 0.25% MgS were less uniform than tablets with 1.0% MgS. In addition, absorbance variations along tablet edges, reflective of corresponding density variation, agreed with force transmission within the tablet and final tablet ejection force. Chemical imaging techniques can be used to non-destructively assess density profiles of tablets, and confirm prediction of friction alleviation and improvement in force distribution during tabletting. The density profiles were both qualitative, showing differences in density profiles between tablets of different blends, and quantitative, providing actual density and tabletting force information within a single tablet. This work demonstrates that near-infrared chemical imaging can be an effective tool in monitoring not only the physical quality of pharmaceutical tablets, but the corresponding die forces controlling tabletting and final ejection. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - TABLETS (Medicine)
KW - MAGNESIUM
KW - IMAGING systems in chemistry
KW - Compaction
KW - Compression
KW - Density
KW - Force transmission
KW - Magnesium stearate
KW - Near-infrared imaging
KW - Powder technology
KW - Shear cell
KW - Wall friction
N1 - Accession Number: 33995358; Ellison, Christopher D. 1; Email Address: christophe.ellison@fda.hhs.gov Ennis, Bryan J. 2; Email Address: bryan.ennis@powdernotes.com Hamad, Mazen L. 1 Lyon, Robbe C. 1; Affiliation: 1: Division of Product Quality Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States 2: E&G Associates, Nashville, TN 37215, United States; Source Info: Sep2008, Vol. 48 Issue 1, p1; Subject Term: DRUG development; Subject Term: TABLETS (Medicine); Subject Term: MAGNESIUM; Subject Term: IMAGING systems in chemistry; Author-Supplied Keyword: Compaction; Author-Supplied Keyword: Compression; Author-Supplied Keyword: Density; Author-Supplied Keyword: Force transmission; Author-Supplied Keyword: Magnesium stearate; Author-Supplied Keyword: Near-infrared imaging; Author-Supplied Keyword: Powder technology; Author-Supplied Keyword: Shear cell; Author-Supplied Keyword: Wall friction; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2008.04.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105550764
T1 - Multi-rule quality control for the age-related eye disease study.
AU - Caudill SP
AU - Schleicher RL
AU - Pirkle JL
Y1 - 2008/09/10/
N1 - Accession Number: 105550764. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research. Journal Subset: Biomedical; USA. NLM UID: 8215016.
KW - Antioxidants -- Therapeutic Use
KW - Cataract -- Drug Therapy
KW - Data Analysis, Statistical
KW - Macular Degeneration -- Drug Therapy
KW - Zinc -- Therapeutic Use
KW - Aged
KW - Blood Chemical Analysis
KW - Cataract -- Blood
KW - Cataract -- Epidemiology
KW - Cataract -- Prevention and Control
KW - Clinical Trials
KW - Disease Progression
KW - Macular Degeneration -- Blood
KW - Macular Degeneration -- Epidemiology
KW - Macular Degeneration -- Prevention and Control
KW - Micronutrients -- Therapeutic Use
KW - Quality Control (Technology)
KW - United States
KW - Human
SP - 4094
EP - 4106
JO - Statistics in Medicine
JF - Statistics in Medicine
JA - STAT MED
VL - 27
IS - 20
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
SN - 0277-6715
AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. spc1@cdc.gov
U2 - PMID: 18344178.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hettick, Justin M.
AU - Green, Brett J.
AU - Buskirk, Amanda D.
AU - Kashon, Michael L.
AU - Slaven, James E.
AU - Janotka, Erika
AU - Blachere, Francoise M.
AU - Schmechel, Detlef
AU - Beezhold, Donald H.
T1 - Discrimination of Aspergillus isolates at the species and strain level by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry fingerprinting
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2008/09/15/
VL - 380
IS - 2
M3 - Article
SP - 276
EP - 281
SN - 00032697
AB - Abstract: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI–TOF MS) was used to generate highly reproducible mass spectral fingerprints for 12 species of fungi of the genus Aspergillus and 5 different strains of Aspergillus flavus. Prior to MALDI–TOF MS analysis, the fungi were subjected to three 1-min bead beating cycles in an acetonitrile/trifluoroacetic acid solvent. The mass spectra contain abundant peaks in the range of 5 to 20kDa and may be used to discriminate between species unambiguously. A discriminant analysis using all peaks from the MALDI–TOF MS data yielded error rates for classification of 0 and 18.75% for resubstitution and cross-validation methods, respectively. If a subset of 28 significant peaks is chosen, resubstitution and cross-validation error rates are 0%. Discriminant analysis of the MALDI–TOF MS data for 5 strains of A. flavus using all peaks yielded error rates for classification of 0 and 5% for resubstitution and cross-validation methods, respectively. These data indicate that MALDI–TOF MS data may be used for unambiguous identification of members of the genus Aspergillus at both the species and strain levels. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ASPERGILLUS
KW - MASS spectrometry
KW - IONIZATION (Atomic physics)
KW - FUNGI
KW - Aspergillus
KW - Fingerprinting
KW - Fungi
KW - MALDI
KW - Mass spectrometry
N1 - Accession Number: 33467240; Hettick, Justin M.; Email Address: jhettick@cdc.gov Green, Brett J. 1 Buskirk, Amanda D. 1 Kashon, Michael L. 1 Slaven, James E. 1 Janotka, Erika 1 Blachere, Francoise M. 1 Schmechel, Detlef 1 Beezhold, Donald H. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA; Source Info: Sep2008, Vol. 380 Issue 2, p276; Subject Term: ASPERGILLUS; Subject Term: MASS spectrometry; Subject Term: IONIZATION (Atomic physics); Subject Term: FUNGI; Author-Supplied Keyword: Aspergillus; Author-Supplied Keyword: Fingerprinting; Author-Supplied Keyword: Fungi; Author-Supplied Keyword: MALDI; Author-Supplied Keyword: Mass spectrometry; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ab.2008.05.051
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jie Zheng
AU - Shenghui Cui
AU - Teel, Louise D.
AU - Shaohua Zhao
AU - Singh, Ruby
AU - O'Brien, Alison D.
AU - Jianghong Meng
T1 - Identification and Characterization of Shiga Toxin Type 2 Variants in Escherichia coli Isolates from Animals, Food, and Humans.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/09/15/
VL - 74
IS - 18
M3 - Article
SP - 5645
EP - 5652
SN - 00992240
AB - There is considerable heterogeneity among the Shiga toxin type 2 (Stx2) toxins elaborated by Shiga toxin-producing Escherichia coli (STEC). One such Stx2 variant, the Stx2d mucus-activatable toxin (Stx2dact), is rendered more toxic by the action of elastase present in intestinal mucus, which cleaves the last two amino acids of the A2 portion of the toxin A subunit. We screened 153 STEC isolates from food, animals, and humans for the gene encoding Stx2dact by using a novel one-step PCR procedure. This method targeted the region of stx2dact that encodes the elastase recognition site. The presence of stx2dact was confirmed by DNA sequencing of the complete toxin genes. Seven STEC isolates from cows (four isolates), meat (two isolates), and a human (one isolate) that carried the putative stx2dact gene were identified; all were eae negative, and none was the O157:H7 serotype. Three of the isolates (CVM9322, CYM9557, and CVM9584) also carried stx1, two (P1332 and P1334) carried stx1 and stx2c, and one (CL-15) carried stx2c. One isolate, P1130, harbored only stx2dact. The Vero cell cytotoxicities of supernatants from P1130 and stx1 deletion mutants of CVM9322, CVM9557, and CVM9584 were increased 13- to 30-fold after treatment with porcine elastase. Thus, Stx2dact-producing strains, as detected by our one-step PCR method, can be isolated not only from humans, as previously documented, but also from food and animals. The latter finding has important public health implications based on a recent report from Europe of a link between disease severity and infection with STEC isolates that produce Stx2dact. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXINS
KW - ESCHERICHIA coli
KW - ANIMALS
KW - FOOD
KW - POLYMERASE chain reaction
KW - NUCLEOTIDE sequence
N1 - Accession Number: 34577533; Jie Zheng 1 Shenghui Cui 1 Teel, Louise D. 2 Shaohua Zhao 3 Singh, Ruby 3 O'Brien, Alison D. 2 Jianghong Meng 1; Email Address: jrneng@umd.edu; Affiliation: 1: Department of Nutrition & Food Science, University of Maryland, College Park, Maryland 20742 2: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 208142 3: Center for Veterinary Medicine, Office of Research, Food and Drug Administration, Laurel, Maryland 20708; Source Info: Sep2008, Vol. 74 Issue 18, p5645; Subject Term: TOXINS; Subject Term: ESCHERICHIA coli; Subject Term: ANIMALS; Subject Term: FOOD; Subject Term: POLYMERASE chain reaction; Subject Term: NUCLEOTIDE sequence; Number of Pages: 8p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1128/AEM.00503-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dominador J. Manalo
AU - Paul W. Buehler
AU - Jin Hyen Baek
AU - Omer Butt
AU - Felice D'agnillo
AU - Abdu I. Alayash
T1 - Acellular haemoglobin attenuates hypoxia-inducible factor-1α (HIF-1α) and its target genes in haemodiluted rats.
JO - Biochemical Journal
JF - Biochemical Journal
Y1 - 2008/09/15/
VL - 414
IS - 3
M3 - Article
SP - 461
EP - 469
SN - 02646021
AB - Hb (haemoglobin)-based blood substitutes represent a class of therapeutics designed to correct oxygen deficit under conditions of anaemia and traumatic blood loss. The influences of these agents on HIF-1α (hypoxia-inducible factor-1α) target genes involved in adaptation to hypoxia have so far not been studied. In the study presented here, rats underwent 80% ET (exchange transfusion) with either HS (hetastarch) or a polymerized Hb OG (Oxyglobin®). HS induced dramatic EPO (erythropoietin) gene transcription, reaching a maximum at 4 h post-ET. In contrast, OG suppressed EPO transcription until approx. 24 h post-ET. Large plasma EPO levels that were observed post-ET with HS were significantly blunted in animals transfused with OG. OG, unlike HS, induced a sharp increase in HO-1 (haem oxygenase-1) transcription at 4 h, which declined rapidly within 24 h, whereas modest increases in iNOS [inducible (nitric oxide synthase)] and constitutive NOS [eNOS (endothelial NOS)] were detected over the control. Our results demonstrate for the first time that severe haemodilution-induced erythropoietic responses in kidneys were attenuated by a low-oxygen-affinity cell-free Hb and suggest that tissue-specific oxygen-sensing pathways can be influenced by allosterically modified Hbs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemical Journal is the property of Portland Press Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEMOGLOBIN
KW - ERYTHROPOIETIN
KW - BLOOD diseases
KW - ANOXEMIA
N1 - Accession Number: 34651986; Dominador J. Manalo 1 Paul W. Buehler 1 Jin Hyen Baek 1 Omer Butt 1 Felice D'agnillo 1 Abdu I. Alayash 1; Affiliation: 1: LBVB (Laboratory of Biochemistry and Vascular Biology), Division of Hematology, CBER (Center for Biologics Evaluation and Research), FDA (Food and Drug Administration), NIH (National Institutes of Health), Bldg 29, Room 112, 8800 Rockville Pike, Bethesda, MD 20892, U.S.A.; Source Info: 2008, Vol. 414 Issue 3, p461; Subject Term: HEMOGLOBIN; Subject Term: ERYTHROPOIETIN; Subject Term: BLOOD diseases; Subject Term: ANOXEMIA; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mnatsakanov, Robert M.
T1 - Hausdorff moment problem: Reconstruction of probability density functions
JO - Statistics & Probability Letters
JF - Statistics & Probability Letters
Y1 - 2008/09/15/
VL - 78
IS - 13
M3 - Article
SP - 1869
EP - 1877
SN - 01677152
AB - Abstract: The problem of recovering a moment-determinate probability density function (pdf) from its moments is studied. The proposed construction provides a method for recovery of different pdfs via simple transformations of the moment sequences. Uniform and -rates of convergence of moment-recovered pdfs are obtained. Finally, some applications and examples are briefly discussed. [Copyright &y& Elsevier]
AB - Copyright of Statistics & Probability Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROBABILITY theory
KW - DENSITY functionals
KW - FUNCTIONAL analysis
KW - STOCHASTIC convergence
N1 - Accession Number: 33992187; Mnatsakanov, Robert M. 1,2; Email Address: rmnatsak@stat.wvu.edu; Affiliation: 1: Department of Statistics, West Virginia University, Morgantown, WV 26506, USA 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA; Source Info: Sep2008, Vol. 78 Issue 13, p1869; Subject Term: PROBABILITY theory; Subject Term: DENSITY functionals; Subject Term: FUNCTIONAL analysis; Subject Term: STOCHASTIC convergence; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.spl.2008.01.054
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rubin, J.
AU - Walker, R.D.
AU - Blickenstaff, K.
AU - Bodeis-Jones, S.
AU - Zhao, S.
T1 - Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2008/09/18/
VL - 131
IS - 1/2
M3 - Article
SP - 164
EP - 172
SN - 03781135
AB - Abstract: Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United States. Three antimicrobial panels, including 6 classes and 32 antimicrobial agents, were used. A wide range of susceptibility patterns were noted with some isolates being resistant to between 8 and 28 (mean 16) of the antimicrobials tested. Among the β-lactams, all isolates were resistant to ampicillin, cefoxitin, cefpodoxime, cephalothin and cefazolin followed by amoxicillin/clavulanic acid (99%), ceftiofur (97%), ceftriaxone (39%), cefotaxime (26%), and cefotaxime/clavulanic acid (20%), whereas less than 7% of isolates were resistant to ceftazidime/clavulanic acid, ceftazidime, piperacillin/tazobactam or cefepime. Two isolates were resistant to the carbapenems. Among the quinolones and fluoroquinolones, the most isolates were resistant to naladixic acid (96%), followed by orbifloxacin (52%), difloxacin (43%), enrofloxacin (31%), marbofloxacin (27%), gatifloxacin (23%), levofloxacin (21%), and ciprofloxacin (16%). Among the aminoglycosides, the most resistance was seen to kanamycin (90%), followed by streptomycin (69%), gentamicin (7%), and amikacin (3%). Of the remaining antimicrobials 100% of the isolates were resistant to chloramphenicol followed by tetracycline (98%), trimethoprim/sulfamethoxazole (57%), and sulfisoxazole (51%). Point mutations were present in gyrA, gyrB, parC, and/or parE genes among 34 of the 102 naladixic acid-resistant isolates. Two isolates contained class 1 integrons carrying aadA gene conferring streptomycin and spectinomycin resistance. The findings suggest that many antimicrobial agents commonly used in companion animals may not constitute appropriate therapy for canine pseudomonas infections. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTI-infective agents
KW - AMINOGLYCOSIDES
KW - ANTIBACTERIAL agents
KW - CO-trimoxazole
KW - BACTERIAL diseases
KW - Antimicrobial resistance
KW - Canine
KW - Class 1 integron
KW - Fluoroquinolones
KW - Pseudomonas aeruginosa
KW - QRDR
N1 - Accession Number: 33887214; Rubin, J. 1 Walker, R.D. 2,3 Blickenstaff, K. 4 Bodeis-Jones, S. 4 Zhao, S. 4; Email Address: shaohua.zhao@FDA.HHS.GOV; Affiliation: 1: Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Canada 2: Anti-infectives Research Consultants, Glade Park, CO 81523, United States 3: Department of Biological Sciences, Mesa State College, Grand Junction, CO 81501, United States 4: Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, United States; Source Info: Sep2008, Vol. 131 Issue 1/2, p164; Subject Term: ANTI-infective agents; Subject Term: AMINOGLYCOSIDES; Subject Term: ANTIBACTERIAL agents; Subject Term: CO-trimoxazole; Subject Term: BACTERIAL diseases; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Canine; Author-Supplied Keyword: Class 1 integron; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Pseudomonas aeruginosa; Author-Supplied Keyword: QRDR; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vetmic.2008.02.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SEDRAKYAN, GEGHAM Z.
AU - EVANS, FREDERICK E.
AU - MINASYAN, SEYRAN H.
AU - TAVADYAN, LEVON A.
AU - WANGILA, GRANT W.
AU - WALKER, RICHARD B.
AU - SORENSON, JOHN R. J.
T1 - NMR and FTIR studies of coordinate-bonding and intramolecular and intermolecular hydrogen bonding in zinc(II)(3,5-diisopropylsalicylate)2.
JO - Journal of Coordination Chemistry
JF - Journal of Coordination Chemistry
Y1 - 2008/09/20/
VL - 61
IS - 18
M3 - Article
SP - 2861
EP - 2875
PB - Taylor & Francis Ltd
SN - 00958972
AB - Carboxylate and salicylic OH coordinate bonding as well as intramolecular and intermolecular hydrogen bonding of bis-3,5-diisopropylsalicylatozinc(II), [ZnII(3,5-DIPS)2], with Lewis bases were studied to determine mechanisms accounting for antioxidant reactivity of ZnII(3,5-DIPS)2. Apparent thermodynamic parameters: Keq, ΔS0, ΔH0, and ΔG0 were determined for these equilibria with bonding of two molecules of dimethyl sulfoxide-d6 (DMSO) or ethyl acetate-d8 (EA) to the ZnII using NMR and FTIR. We conclude that addition of two equivalents of DMSO or EA to non-polar solutions of ZnII(3,5-DIPS)2 results in bonding of DMSO or EA to ZnII via sulfoxide or ester carbonyl oxygen atoms with ternary complex formation, leading to weakening of carboxylate and salicylic OH coordinate bonding to ZnII and strengthening intramolecular hydrogen bonding between protons of salicylic OH groups and carboxylate oxygens. Subsequent addition of two or three additional equivalents of DMSO or EA leads to intermolecular hydrogen bonding between protons of salicylic OH groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Coordination Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROGEN bonding
KW - NUCLEAR magnetic resonance
KW - FOURIER transform infrared spectroscopy
KW - PROTONS
KW - MOLECULES
KW - Bis-3,5-diisopropylsalicylatozinc(II)
KW - Coordinate bonding
KW - FTIR
KW - Intramolecular and intermolecular hydrogen bonding
KW - NMR
N1 - Accession Number: 33881199; SEDRAKYAN, GEGHAM Z. 1 EVANS, FREDERICK E. 2 MINASYAN, SEYRAN H. 1 TAVADYAN, LEVON A. 1; Email Address: tavadyan@ichph.sci.am WANGILA, GRANT W. 3 WALKER, RICHARD B. 3 SORENSON, JOHN R. J. 3,4; Affiliation: 1: Institute of Chemical Physics, National Academy of Sciences, Yerevan 0014, Armenia 2: Division of Chemistry, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA 3: Department of Chemistry and Physics, University of Arkansas at Pine Bluff, Pine Bluff, Arkansas 71601, USA 4: Department of Pharmaceutical Sciences, College of Pharmacy, Division of Medicinal Chemistry, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205-7122, USA; Source Info: Sep2008, Vol. 61 Issue 18, p2861; Subject Term: HYDROGEN bonding; Subject Term: NUCLEAR magnetic resonance; Subject Term: FOURIER transform infrared spectroscopy; Subject Term: PROTONS; Subject Term: MOLECULES; Author-Supplied Keyword: Bis-3,5-diisopropylsalicylatozinc(II); Author-Supplied Keyword: Coordinate bonding; Author-Supplied Keyword: FTIR; Author-Supplied Keyword: Intramolecular and intermolecular hydrogen bonding; Author-Supplied Keyword: NMR; Number of Pages: 15p; Illustrations: 2 Diagrams, 2 Charts, 7 Graphs; Document Type: Article
L3 - 10.1080/00958970802087086
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33881199&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lute, Scott
AU - Norling, Lenore
AU - Hanson, Michael
AU - Emery, Rachel
AU - Stinson, Denise
AU - Padua, Kevin
AU - Blank, Greg
AU - Chen, Qi
AU - Brorson, Kurt
T1 - Robustness of virus removal by protein A chromatography is independent of media lifetime
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/09/26/
VL - 1205
IS - 1/2
M3 - Article
SP - 17
EP - 25
SN - 00219673
AB - Abstract: The robustness of virus clearance with respect to protein A media reuse was demonstrated using media with four matrix chemistries: Protein A immobilized ProSep A, Poros A50, Protein A ceramic Hyper DF and MabSelect SuRe, an alkali resistant protein A ligand. Endogenous retrovirus clearance, step yield, impurity clearance and other performance parameters were evaluated periodically in media cycled up to 300 times. Media lifetime was generally limited by either declining step yield or media fouling. However, clearance of endogenous retrovirus remained in an acceptable range, either increasing or remaining constant. Multiply cycled media were tested for clearance of three viruses (SV40, X-MuLV, and MMV); clearance was comparable to naïve media. Overall, virus clearance by protein A chromatography appears to be extremely robust with respect to media age. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMATOGRAPHIC analysis
KW - PROTEINS
KW - RETROVIRUSES
KW - MONOCLONAL antibodies
KW - EFFECT of drugs on viruses
KW - LIGANDS (Biochemistry)
KW - Media lifetime
KW - Monoclonal antibodies
KW - Protein A chromatography
KW - Viral removal
N1 - Accession Number: 34201574; Lute, Scott 1 Norling, Lenore 2 Hanson, Michael 1,3 Emery, Rachel 2 Stinson, Denise 2 Padua, Kevin 2 Blank, Greg 2 Chen, Qi 2 Brorson, Kurt 1; Email Address: kurt.brorson@fda.hhs.gov; Affiliation: 1: Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Late Stage Purification, Process Development, Genentech Inc., One DNA Way, South San Francisco, CA 94080, USA 3: Department of Chemical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA; Source Info: Sep2008, Vol. 1205 Issue 1/2, p17; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PROTEINS; Subject Term: RETROVIRUSES; Subject Term: MONOCLONAL antibodies; Subject Term: EFFECT of drugs on viruses; Subject Term: LIGANDS (Biochemistry); Author-Supplied Keyword: Media lifetime; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: Protein A chromatography; Author-Supplied Keyword: Viral removal; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2008.07.094
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34201574&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Boureiko, Anna
AU - Melnyk, Stepan
AU - Bagnyukova, Tetyana V.
AU - Montgomery, Beverly
AU - Rusyn, Ivan
T1 - Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2008/09/26/
VL - 644
IS - 1/2
M3 - Article
SP - 17
EP - 23
SN - 00275107
AB - Abstract: Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive predictive markers in animal testing for carcinogenic potency of environmental agents. Alterations in metabolism of methyl donors, disturbances in activity and/or expression of DNA methyltransferases, and presence of DNA single-strand breaks could contribute to the loss of cytosine methylation during carcinogenesis; however, the precise mechanisms of genomic hypomethylation induced by chemical carcinogens remain largely unknown. This study examined the mechanism of DNA hypomethylation during hepatocarcinogenesis induced by peroxisome proliferators WY-14,643 (4-chloro-6-(2,3-xylidino)-pyrimidynylthioacetic acid) and DEHP (di-(2-ethylhexyl)phthalate), agents acting through non-genotoxic mode of action. In the liver of male Fisher 344 rats exposed to WY-14,643 (0.1% (w/w), 5 months), the level of genomic hypomethylation increased by ∼2-fold, as compared to age-matched controls, while in the DEHP group (1.2% (w/w), 5 months) DNA methylation did not change. Global DNA hypomethylation in livers from WY-14,643 group was accompanied by the accumulation of DNA single-strand breaks, increased cell proliferation, and diminished expression of DNA methyltransferase 1, while the metabolism of methyl donors was not affected. In contrast, none of these parameters changed significantly in rats fed DEHP. Since WY-14,643 is much more potent carcinogen than DEHP, we conclude that the extent of loss of DNA methylation may be related to the carcinogenic potential of the chemical agent, and that accumulation of DNA single-strand breaks coupled to the increase in cell proliferation and altered DNA methyltransferase expression may explain genomic hypomethylation during peroxisome proliferator-induced carcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLATION
KW - CELLULAR growth
KW - CARCINOGENESIS
KW - HAZARDOUS substances
KW - Cell proliferation
KW - DNA damage
KW - DNA hypomethylation
KW - Peroxisome proliferators
N1 - Accession Number: 33999980; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Tryndyak, Volodymyr P. 1 Boureiko, Anna 1 Melnyk, Stepan 2 Bagnyukova, Tetyana V. 1 Montgomery, Beverly 1 Rusyn, Ivan 3; Email Address: ivan_rusyn@unc.edu; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA; Source Info: Sep2008, Vol. 644 Issue 1/2, p17; Subject Term: METHYLATION; Subject Term: CELLULAR growth; Subject Term: CARCINOGENESIS; Subject Term: HAZARDOUS substances; Author-Supplied Keyword: Cell proliferation; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: DNA hypomethylation; Author-Supplied Keyword: Peroxisome proliferators; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2008.06.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33999980&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Jagger, Janine
AU - Gomaa, Ahmed E.
AU - Phillips, Elayne K.
T1 - Safety of surgical personnel: a global concern.
JO - Lancet
JF - Lancet
Y1 - 2008/09/27/
VL - 372
IS - 9644
M3 - Letter
SP - 1149
EP - 1149
SN - 00995355
AB - This letter to the editor comments on the editorial "An Estimation of the Global Volume of Surgery: A Modeling Strategy Based on Available Data" from the July 12, 2008 issue of this journal.
KW - SURGERY -- Safety measures
KW - LETTERS to the editor
N1 - Accession Number: 34565734; Jagger, Janine 1; Email Address: jcj@virginia.edu Gomaa, Ahmed E. 2 Phillips, Elayne K. 1; Affiliation: 1: University of Virginia, Charlottesville, VA 22908, USA 2: National Institute for Occupational Safety and Health, Cincinnati, OH, USA; Source Info: 9/27/2008, Vol. 372 Issue 9644, p1149; Subject Term: SURGERY -- Safety measures; Subject Term: LETTERS to the editor; Number of Pages: 2/5p; Document Type: Letter
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34565734&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miyagi, Eri
AU - Schwartzkopff, Franziska
AU - Plishka, Ronald
AU - Buckler-White, Alicia
AU - Clouse, Kathleen A.
AU - Strebel, Klaus
T1 - APOBEC3G-independent reduction in virion infectivity during long-term HIV-1 replication in terminally differentiated macrophages
JO - Virology
JF - Virology
Y1 - 2008/09/30/
VL - 379
IS - 2
M3 - Article
SP - 266
EP - 274
SN - 00426822
AB - Abstract: APOBEC3G (APO3G) is a cellular cytidine deaminase with potent antiviral activity. In the case of HIV, the antiviral activity of APO3G is counteracted by the viral Vif protein. Monocyte-derived macrophages (MDM) are terminally differentiated, non-dividing cells susceptible to HIV infection. Human MDM are known to express APO3G and HIV replication in these cells is dependent on Vif. Here we analyzed the correlation between HIV-1 replication and APO3G expression in MDM. Replication of wild type HIV-1 induced a gradual 4–5-fold reduction in APO3G expression. The efficiency of APO3G downregulation correlated with the efficiency of virus replication. Interestingly, despite downregulation of APO3G, the relative infectivity of viruses rapidly declined during the course of infection and was already reduced ∼90% prior to peak virus production. Cell-free virus preparations showed increased levels of a 41 kDa MA–CA processing intermediate. Sequence analysis around the MA–CA cleavage site and the protease and LTR regions did not reveal deaminase-induced hypermutation of the viral genome, suggesting that APO3G activity is not responsible for the incomplete Gag processing. Thus, the loss of infectivity of HIV-1 viruses produced from long-term infected primary macrophages is due to an APO3G-independent mechanism. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - RESEARCH
KW - VIRAL proteins
KW - HIV infections
KW - MACROPHAGES
KW - VIRAL replication
KW - VIRAL genomes
KW - APOBEC3G
KW - HIV-1
KW - Macrophages
KW - Vif
N1 - Accession Number: 34210850; Miyagi, Eri 1 Schwartzkopff, Franziska 2 Plishka, Ronald 3 Buckler-White, Alicia 3 Clouse, Kathleen A. 2 Strebel, Klaus 1; Email Address: kstrebel@nih.gov; Affiliation: 1: Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA 2: Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA 3: Molecular Biology Core, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460, USA; Source Info: Sep2008, Vol. 379 Issue 2, p266; Subject Term: ANTIVIRAL agents; Subject Term: RESEARCH; Subject Term: VIRAL proteins; Subject Term: HIV infections; Subject Term: MACROPHAGES; Subject Term: VIRAL replication; Subject Term: VIRAL genomes; Author-Supplied Keyword: APOBEC3G; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: Macrophages; Author-Supplied Keyword: Vif; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2008.06.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34210850&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105583776
T1 - A framework for guiding health literacy research in populations with universal access to healthcare.
AU - Weld KK
AU - Padden D
AU - Ramsey G
AU - Bibb SCG
Y1 - 2008/10//Oct-Dec2008
N1 - Accession Number: 105583776. Language: English. Entry Date: 20090213. Revision Date: 20150818. Publication Type: Journal Article; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. NLM UID: 7809992.
KW - Health Services Accessibility
KW - Literacy
KW - Military Services
KW - Research
KW - Theory
KW - Health Literacy
KW - Bandura's Social Cognitive Theory
KW - Conceptual Framework
KW - Health Belief Model
KW - Healthy People 2010
KW - Institute of Medicine (U.S.)
KW - Literacy -- Evaluation
KW - Patient Education
SP - 308
EP - 318
JO - Advances in Nursing Science
JF - Advances in Nursing Science
JA - ANS
VL - 31
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - At least one third of the US population suffers from limited health literacy, which has been linked to poorer health status, higher costs, and individuals who are socioeconomically disadvantaged. However, research and the development of theoretical frameworks to study health literacy have only recently begun to occur. The purpose of this article is to describe theoretical frameworks that have either been used or may be used to guide health literacy research and to identify implications for nursing research and practice related to an adaptation of a health literacy framework developed specifically for conducting research in populations with universal access to healthcare.
SN - 0161-9268
AD - US Public Health Service; kweld@usuhs.mil
U2 - PMID: 19033746.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105583776&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105565832
T1 - Historical paper. Mortality of persons with photofluorograms suggestive of cardiovascular disease...Reprinted with permission from the Massachusetts Medical Society (New England Journal of Medicine 1953 June 18;248:1045-1050)
AU - Comstock GW
Y1 - 2008/10//
N1 - Accession Number: 105565832. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; historical material; tables/charts. Commentary: Kuller LH. Commentary: George W. Comstock and noninvasive imaging, 1950s-style. (AM J EPIDEMIOL) Oct2008; 168 (7): 712-714. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Cardiovascular Diseases -- Diagnosis
KW - Cardiovascular Diseases -- Radiography
KW - Mortality -- Prevention and Control
KW - Cardiovascular Risk Factors
KW - Early Intervention
KW - Epidemiological Research -- Georgia
KW - Georgia
KW - Mortality -- Trends
KW - Race Factors
KW - Radiography -- Trends
KW - Tuberculosis -- Radiography
SP - 715
EP - 732
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 168
IS - 7
PB - Oxford University Press / USA
SN - 0002-9262
AD - Senior surgeon, US Public Health Service, assigned as a director, Muscogee County Tuberculosis Study
U2 - PMID: 18820269.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105565832&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105565834
T1 - Historical paper. An epidemiologic study of blood pressure levels in a biracial community in the southern United States...Am J Hyg 1957, Vol. 65:271-315
AU - Comstock GW
Y1 - 2008/10//
N1 - Accession Number: 105565834. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; historical material; research; tables/charts. Commentary: Kuller LH. Commentary: George W. Comstock and noninvasive imaging, 1950s-style. (AM J EPIDEMIOL) Oct2008; 168 (7): 712-714. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Epidemiological Research -- Georgia
KW - Hypertension -- Epidemiology
KW - Race Factors
KW - Age Factors
KW - Blood Pressure Determination -- Methods
KW - Census
KW - Comparative Studies
KW - Correlational Studies
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Factor Analysis
KW - Georgia
KW - Health Status
KW - Interrater Reliability
KW - Obesity
KW - Quantitative Studies
KW - Random Sample
KW - Sex Factors
KW - Socioeconomic Factors
KW - Human
SP - 733
EP - 777
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 168
IS - 7
PB - Oxford University Press / USA
SN - 0002-9262
AD - Tuberculosis Program, U.S. Public Health Service, Department of Health, Education and Welfare, Washington, D.C.
U2 - PMID: 18820270.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105565834&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Violanti, John M.
AU - Charles, Luenda E.
AU - Hartley, Tara A.
AU - Mnatsakanova, Anna
AU - Andrew, Michael E.
AU - Fekedulegn, Desta
AU - Vila, Bryan
AU - Burchfiel, Cecil M.
T1 - Shift-Work and Suicide Ideation Among Police Officers.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/10//
VL - 51
IS - 10
M3 - Article
SP - 758
EP - 768
SN - 02713586
AB - The article reports on the shift-work and suicide ideation among police officers. It discusses that nail guns were evaluated over 3 years among carpenters enrolled in two apprenticeship programs in the Midwest. It infers that as apprentices received trainings and safer trigger exposures in the said field, widespread decrease in injury rates were observed. It is also inferred that most common mechanisms of injury were caught in or between parts of equipment, being struck by or against equipment and electrocution.
KW - Death (Biology)
KW - Police
KW - Security systems
KW - Criminal justice administration
KW - Death -- Causes
KW - Violent deaths
KW - Criminal justice personnel
KW - Peace officers
KW - Sheriffs
KW - depression
KW - police
KW - PTSD
KW - shift work
KW - suicide ideation
N1 - Accession Number: 34386224; Violanti, John M. 1; Email Address: violanti@buftalo.edu; Charles, Luenda E. 2; Hartley, Tara A. 2; Mnatsakanova, Anna 2; Andrew, Michael E. 2; Fekedulegn, Desta 2; Vila, Bryan 3; Burchfiel, Cecil M. 2; Affiliations: 1: Department of Social & Preventive Medicine, School of Public Health & Health Professions, State University of NY at Buffalo, Buffalo, New York; 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health [NIOSH],Centers for Disease Control and Prevention, Morgantown, West Virginia; 3: Criminal Justice Program and Sleep and Performance Research Center, Washington State University, Spokane, Washington; Issue Info: Oct2008, Vol. 51 Issue 10, p758; Thesaurus Term: Death (Biology); Subject Term: Police; Subject Term: Security systems; Subject Term: Criminal justice administration; Subject Term: Death -- Causes; Subject Term: Violent deaths; Subject Term: Criminal justice personnel; Subject Term: Peace officers; Subject Term: Sheriffs; Author-Supplied Keyword: depression; Author-Supplied Keyword: police; Author-Supplied Keyword: PTSD; Author-Supplied Keyword: shift work; Author-Supplied Keyword: suicide ideation; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 912130 Provincial police services; NAICS/Industry Codes: 561621 Security Systems Services (except Locksmiths); Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1002/ajim.20629
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34386224&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cheng-Xiong Xu
AU - Hua Jin
AU - Hwang-Tae Lim
AU - Ji-Eun Kim
AU - Ji-Young Shin
AU - Eun-Sun Lee
AU - Youn-Sun Chung
AU - Yeon-Sook Lee
AU - George Beck Jr.
AU - Kee Ho Lee
AU - Myung-Haing Cho
T1 - High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice.
JO - American Journal of Physiology: Gastrointestinal & Liver Physiology
JF - American Journal of Physiology: Gastrointestinal & Liver Physiology
Y1 - 2008/10//
VL - 58
IS - 4
M3 - Article
SP - G654
EP - G663
SN - 01931857
AB - Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Recent studies have indicated that Pi affects Akt signaling through the sodium-dependent phosphate cotransporter. Akt signaling, in turn, plays an important role in liver development; however, the effects of high dietary Pi on the liver have not been investigated. Here, we examined the effects of high dietary phosphate on the liver in developing mice. We found that high dietary Pi increased liver mass through enhancing Akt-related cap-dependent protein translation, cell cycle progression, and angiogenesis. Thus careful regulation of Pi consumption may be important in maintaining normal development of the liver. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Gastrointestinal & Liver Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATES
KW - NEOVASCULARIZATION
KW - LIVER -- Physiology
KW - SODIUM phosphates
KW - LOW protein diet
KW - Akt
KW - liver development
N1 - Accession Number: 34777506; Cheng-Xiong Xu 1; Email Address: mchotox@snu.ac.kr Hua Jin 2 Hwang-Tae Lim 1 Ji-Eun Kim 1,3 Ji-Young Shin 1 Eun-Sun Lee 1 Youn-Sun Chung 1 Yeon-Sook Lee 4 George Beck Jr. 5 Kee Ho Lee 6 Myung-Haing Cho 1,3,7; Affiliation: 1: Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea 2: Center for Developmental Pharmacology and Toxicology, Seattle Children's Hospital Research Institute, Seattle, Washington 3: Nano Systems Institute-National Core Research Center, Seoul National University, Seoul, Korea 4: Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea 5: Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia 6: Laboratory of Radiation Molecular Oncology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea 7: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Source Info: Oct2008, Vol. 58 Issue 4, pG654; Subject Term: PHOSPHATES; Subject Term: NEOVASCULARIZATION; Subject Term: LIVER -- Physiology; Subject Term: SODIUM phosphates; Subject Term: LOW protein diet; Author-Supplied Keyword: Akt; Author-Supplied Keyword: liver development; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 10p; Illustrations: 7 Graphs; Document Type: Article
L3 - 10.1152/ajpgi.90213.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shvedova, A. A.
AU - Kisin, E.
AU - Murray, A. R.
AU - Johnson, V. J.
AU - Gorelik, O.
AU - Arepalli, S.
AU - Hubbs, A. F.
AU - Mercer, R. R.
AU - Keohavong, P.
AU - Sussman, N.
AU - Jin, J.
AU - Yin, J.
AU - Stone, S.
AU - Chen, B. T.
AU - ' G. Deye
AU - Maynard, A.
AU - Castranova, V.
AU - Baron, P. A.
AU - Kagan, V. E.
T1 - Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
JO - American Journal of Physiology: Lung Cellular & Molecular Physiology
JF - American Journal of Physiology: Lung Cellular & Molecular Physiology
Y1 - 2008/10//
VL - 39
IS - 4
M3 - Article
SP - L552
EP - L565
SN - 10400605
AB - Nanomaterials are frontier technological products used in different manufactured goods. Because of their unique physicochernical, electrical, mechanical, and thermal properties, single-walled carbon nanotubes (SWCNT) are finding numerous applications in electronics, aerospace devices, computers, and chemical, polymer, and pharmaceutical industries. SWCNT are relatively recently discovered members of the carbon allotropes that are similar in structure to fullerenes and graphite. Previously, we (47) have reported that pharyngeal aspiration of purified SWCNT by C57BL/6 mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function. To avoid potential artifactual effects due to instillation/agglomeration associated with SWCNT, we conducted inhalation exposures using stable and uniform SWCNT dispersions obtained by a newly developed aerosolization technique (2). The inhalation of nonpurified SWCNT (iron content of 17.7% by weight) at 5 mg/m², 5 h/day for 4 days was compared with pharyngeal aspiration of varying doses (5-20 µg per mouse) of the same SWCNT. The chain of pathological events in both exposure routes was realized through synergized interactions of early inflammatory response and oxidative stress culminating in the development of multifocal granulornatous pneumonia and interstitial fibrosis. SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Lung Cellular & Molecular Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON nanotubes
KW - NANOSTRUCTURED materials
KW - FIBROSIS
KW - OXIDATIVE stress
KW - MUTAGENESIS
KW - PHYSIOLOGY
KW - lung disease
KW - nanoparticles
N1 - Accession Number: 34989083; Shvedova, A. A. 1,2; Email Address: ats1@cdc.gov Kisin, E. 1 Murray, A. R. 1 Johnson, V. J. 3 Gorelik, O. 4,5 Arepalli, S. 4,5 Hubbs, A. F. 1 Mercer, R. R. 1,2 Keohavong, P. 6 Sussman, N. 6 Jin, J. 6 Yin, J. 6 Stone, S. 1 Chen, B. T. 1 ' G. Deye 7 Maynard, A. 8 Castranova, V. 1,2,6 Baron, P. A. 7 Kagan, V. E. 6; Affiliation: 1: Pathology and Physiology Research Branch 2: Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 3: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH) 4: Lockheed Martin, Engineering Directorate, Materials and Processes Branch 5: Nanotube Team, GB Tech, National Aeronautics and Space Administration Johnson Space Center, Houston, Texas 6: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 7: Monitoring Research and Statistical Activity, Division of Applied Research and Technology, NIOSH, Cincinnati, Ohio 8: Woodrow Wilson International Center for Scholars, Washington, District of Columbia; Source Info: Oct2008, Vol. 39 Issue 4, pL552; Subject Term: CARBON nanotubes; Subject Term: NANOSTRUCTURED materials; Subject Term: FIBROSIS; Subject Term: OXIDATIVE stress; Subject Term: MUTAGENESIS; Subject Term: PHYSIOLOGY; Author-Supplied Keyword: lung disease; Author-Supplied Keyword: nanoparticles; Number of Pages: 14p; Illustrations: 4 Charts, 12 Graphs; Document Type: Article
L3 - 10.1152/ajplung.90287.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105575523
T1 - Multivariate analysis of state variation in breastfeeding rates in the United States.
AU - Kogan MD
AU - Singh GK
AU - Dee DL
AU - Belanoff C
AU - Grummer-Strawn LM
Y1 - 2008/10//
N1 - Accession Number: 105575523. Language: English. Entry Date: 20090102. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Breast Feeding -- Trends -- United States
KW - Health Promotion -- Legislation and Jurisprudence -- United States
KW - Mothers -- Education
KW - Attitude to Breast Feeding
KW - Child, Preschool
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Geographic Factors
KW - Health Knowledge
KW - Health Policy
KW - Housing
KW - Infant
KW - Infant, Newborn
KW - Logistic Regression
KW - Multivariate Analysis
KW - Odds Ratio
KW - Poverty
KW - Secondary Analysis
KW - Social Values
KW - Socioeconomic Factors
KW - Surveys
KW - United States
KW - Human
SP - 1872
EP - 1880
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 98
IS - 10
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We sought to determine the impact of sociodemographic and behavioral factors and state legislation on breastfeeding initiation (child ever fed breastmilk) and duration. METHODS: We used data from a nationally representative study of children aged 6 to 71 months (N = 33 121); we calculated unadjusted and adjusted state estimates for breastfeeding initiation and duration. We used logistic regression models to examine factors associated with never breastfeeding or breastfeeding less than 6 months. We conducted a multilevel analysis of state legislation's role. RESULTS: There were wide state variations in breastfeeding initiation and duration. The western and northwestern states had the highest rates. Covariate adjustment accounted for 25% to 30% of the disparity. Multivariate analysis showed that the adjusted odds of not being breastfed were 2.5- to 5.15-times greater in southern states compared with Oregon (reference). Children in states without breastfeeding legislation had higher odds of not being breastfed. CONCLUSIONS: Sociodemographic and maternal factors do not account for most breastfeeding rate variation. The association with breastfeeding legislation should be explored and may reflect cultural norms.
SN - 0090-0036
AD - Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA. mkogan@hrsa.gov
U2 - PMID: 18703441.
DO - 10.2105/AJPH.2007.127118
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schantz, Michele M.
AU - Bedner, Mary
AU - Long, Stephen E.
AU - Molloy, John L.
AU - Murphy, Karen E.
AU - Porter, Barbara J.
AU - Putzbach, Karsten
AU - Rimmer, Catherine A.
AU - Sander, Lane C.
AU - Sharpless, Katherine E.
AU - Thomas, Jeanice B.
AU - Wise, Stephen A.
AU - Wood, Laura J.
AU - Yen, James H.
AU - Yarita, Takashi
AU - NguyenPho, Agnes
AU - Sorenson, Wendy R.
AU - Betz, Joseph M.
T1 - Development of saw palmetto ( Serenoa repens) fruit and extract standard reference materials.
JO - Analytical & Bioanalytical Chemistry
JF - Analytical & Bioanalytical Chemistry
Y1 - 2008/10//
VL - 392
IS - 3
M3 - Article
SP - 427
EP - 438
PB - Springer Science & Business Media B.V.
SN - 16182642
AB - As part of a collaboration with the National Institutes of Health’s Office of Dietary Supplements and the Food and Drug Administration’s Center for Drug Evaluation and Research, the National Institute of Standards and Technology has developed two standard reference materials (SRMs) representing different forms of saw palmetto ( Serenoa repens), SRM 3250 Serenoa repens fruit and SRM 3251 Serenoa repens extract. Both of these SRMs have been characterized for their fatty acid and phytosterol content. The fatty acid concentration values are based on results from gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC/MS) analysis while the sterol concentration values are based on results from GC-FID and liquid chromatography with mass spectrometry analysis. In addition, SRM 3250 has been characterized for lead content, and SRM 3251 has been characterized for the content of β-carotene and tocopherols. SRM 3250 (fruit) has certified concentration values for three phytosterols, 14 fatty acids as triglycerides, and lead along with reference concentration values for four fatty acids as triglycerides and 16 free fatty acids. SRM 3251 (extract) has certified concentration values for three phytosterols, 17 fatty acids as triglycerides, β-carotene, and γ-tocopherol along with reference concentration values for three fatty acids as triglycerides, 17 fatty acids as free fatty acids, β-carotene isomers, and δ-tocopherol and information values for two phytosterols. These SRMs will complement other reference materials currently available with concentrations for similar analytes and are part of a series of SRMs being developed for dietary supplements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical & Bioanalytical Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAW palmetto
KW - REFERENCE sources
KW - EXTRACTS
KW - PALMS
KW - FRUIT
KW - Certified reference material
KW - Fatty acids
KW - Phytosterols
KW - Saw palmetto
KW - Serenoa repens
KW - Standard reference material
N1 - Accession Number: 34178674; Schantz, Michele M. 1; Email Address: michele.schantz@nist.gov Bedner, Mary 1 Long, Stephen E. 1 Molloy, John L. 1 Murphy, Karen E. 1 Porter, Barbara J. 1 Putzbach, Karsten 1 Rimmer, Catherine A. 1 Sander, Lane C. 1 Sharpless, Katherine E. 1 Thomas, Jeanice B. 1 Wise, Stephen A. 1 Wood, Laura J. 1 Yen, James H. 2 Yarita, Takashi 1 NguyenPho, Agnes 3 Sorenson, Wendy R. 4 Betz, Joseph M. 5; Affiliation: 1: Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA 2: Statistical Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA 3: Center for Drug Evaluation and Research (CDER), Food and Drug Administration, Silver Spring, MD 20993, USA 4: Covance Laboratories , 3301 Kinsman Blvd Madison 53704 USA 5: Office of Dietary Supplements , National Institutes of Health , Bethesda 20892 USA; Source Info: Oct2008, Vol. 392 Issue 3, p427; Subject Term: SAW palmetto; Subject Term: REFERENCE sources; Subject Term: EXTRACTS; Subject Term: PALMS; Subject Term: FRUIT; Author-Supplied Keyword: Certified reference material; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Phytosterols; Author-Supplied Keyword: Saw palmetto; Author-Supplied Keyword: Serenoa repens; Author-Supplied Keyword: Standard reference material; NAICS/Industry Codes: 311942 Spice and Extract Manufacturing; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; Number of Pages: 12p; Illustrations: 2 Diagrams, 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s00216-008-2297-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105627153
T1 - A framework for the concurrent consideration of occupational hazards and obesity.
AU - Schulte PA
AU - Wagner GR
AU - Downes A
AU - Miller DB
Y1 - 2008/10//
N1 - Accession Number: 105627153. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Obesity -- Complications
KW - Occupational Health
KW - Animals
KW - Obesity -- Prevention and Control
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Risk Factors
SP - 555
EP - 566
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 52
IS - 7
PB - Oxford University Press / USA
SN - 0003-4878
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
U2 - PMID: 18765399.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ali, Syed F.
AU - Kuhar, Michael J.
T1 - Preface.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2008/10//
VL - 1139
M3 - Article
SP - xiii
EP - xiv
SN - 00778923
AB - A preface for the 2008 issue of the "Annals of the New York Academy of Sciences," is presented.
KW - DRUG abuse
KW - PREFACES & forewords
N1 - Accession Number: 34630224; Ali, Syed F. 1 Kuhar, Michael J. 2; Affiliation: 1: National Center for Toxicological Research/FDA, Jefferson, Arkansas 2: Emory University, Atlanta, Georgia; Source Info: Oct2008, Vol. 1139, pxiii; Subject Term: DRUG abuse; Subject Term: PREFACES & forewords; Number of Pages: 2p; Document Type: Article
L3 - 10.1196/annals.1432.000
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105693682
T1 - AHRQ commentary. The importance of simulation: preventing hand-off mistakes.
AU - Clancy CM
Y1 - 2008/10//
N1 - Accession Number: 105693682. Language: English. Entry Date: 20081121. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0372403.
KW - Communication
KW - Hand Off (Patient Safety)
KW - Interprofessional Relations
KW - Perioperative Care
KW - Reports
KW - Anesthesiologists
KW - Perianesthesia Nursing
KW - Perioperative Nursing
KW - Post Anesthesia Care Units
KW - Simulations
SP - 625
EP - 627
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 88
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Director, Agency for Healthcare Research and Quality
U2 - PMID: 18928964.
DO - 10.1016/j.aorn.2008.09.007
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jung, Carina M.
AU - Heinze, Thomas M.
AU - Deck, Joanna
AU - Strakosha, Ruth
AU - Sutherland, John B.
T1 - Transformation of N-Phenylpiperazine by Mixed Cultures from a Municipal Wastewater Treatment Plant.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/10//
VL - 74
IS - 19
M3 - Article
SP - 6147
EP - 6150
SN - 00992240
AB - Samples from a wastewater treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter-1) disappeared in 12 days, with the appearance of a transient metabolite and two nitrosated compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WASTEWATER treatment
KW - WASTE products
KW - ANTI-infective agents
KW - BACTERIA
KW - MICROBIOLOGY
KW - MICROBIAL ecology
N1 - Accession Number: 34753017; Jung, Carina M. 1 Heinze, Thomas M. 2 Deck, Joanna 1 Strakosha, Ruth 1 Sutherland, John B. 1; Email Address: john.sutherland@fda.hhs.gov; Affiliation: 1: Divisions of Microbiology 2: Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; Source Info: Oct2008, Vol. 74 Issue 19, p6147; Subject Term: WASTEWATER treatment; Subject Term: WASTE products; Subject Term: ANTI-infective agents; Subject Term: BACTERIA; Subject Term: MICROBIOLOGY; Subject Term: MICROBIAL ecology; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 423930 Recyclable Material Merchant Wholesalers; NAICS/Industry Codes: 562111 Solid Waste Collection; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; Number of Pages: 4p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1128/AEM.00516-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mizanur, Rahman
AU - Pohl, Nicola
T1 - Bacterial CMP-sialic acid synthetases: production, properties, and applications.
JO - Applied Microbiology & Biotechnology
JF - Applied Microbiology & Biotechnology
Y1 - 2008/10//
VL - 80
IS - 5
M3 - Article
SP - 757
EP - 765
PB - Springer Science & Business Media B.V.
SN - 01757598
AB - Sialic acids are abundant nine-carbon sugars expressed terminally on glycoconjugates of eukaryotic cells and are crucial for a variety of cell biological functions such as cell–cell adhesion, intracellular signaling, and in regulation of glycoproteins stability. In bacteria, N-acetylneuraminic acid (Neu5Ac) polymers are important virulence factors. Cytidine 5′-monophosphate (CMP)- N-acetylneuraminic acid synthetase (CSS; EC 2.7.7.43), the key enzyme that synthesizes CMP- N-acetylneuraminic acid, the donor molecule for numerous sialyltransferase reactions, is present in both prokaryotes and eukaryotic systems. Herein, we emphasize the source, function, and biotechnological applications of CSS enzymes from bacterial sources. To date, only a few CSS from pathogenic bacterial species such as Neisseria meningitidis, Escherichia coli, group B streptococci, Haemophilus ducreyi, and Pasteurella hemolytica and an enzyme from nonpathogenic bacterium, Clostridium thermocellum, have been described. Overall, the enzymes from both Gram-positive and Gram-negative bacteria share common catalytic properties such as their dependency on divalent cation, temperature and pH profiles, and catalytic mechanisms. The enzymes, however, can be categorized as smaller and larger enzymes depending on their molecular weight. The larger enzymes in some cases are bifunctional; they have exhibited acetylhydrolase activity in addition to their sugar nucleotidyltransferase activity. The CSSs are important enzymes for the chemoenzymatic synthesis of various sialooligosaccharides of significance in biotechnology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EUKARYOTIC cells
KW - CELL adhesion
KW - ENTEROBACTERIACEAE
KW - HYDROGEN-ion concentration
KW - NEISSERIA meningitidis
KW - FUNGUS-bacterium relationships
KW - GRAM-negative bacteria
KW - ENZYMOLOGY
KW - CATALYSTS
KW - MOLECULAR weights
KW - CMP-sialic acid synthetases
KW - Sialic acid
KW - Sugar nucleotide
N1 - Accession Number: 34338997; Mizanur, Rahman 1; Email Address: rahman.mizanur@fda.hhs.gov Pohl, Nicola 2; Email Address: npohl@iastate.edu; Affiliation: 1: Center for Biologics Evaluation and Research , Food and Drug Administration , 8800 Rockville Pike Bethesda 20892 USA 2: Department of Chemistry and the Plant Sciences Institute , Iowa State University , Ames 50011 USA; Source Info: Oct2008, Vol. 80 Issue 5, p757; Subject Term: EUKARYOTIC cells; Subject Term: CELL adhesion; Subject Term: ENTEROBACTERIACEAE; Subject Term: HYDROGEN-ion concentration; Subject Term: NEISSERIA meningitidis; Subject Term: FUNGUS-bacterium relationships; Subject Term: GRAM-negative bacteria; Subject Term: ENZYMOLOGY; Subject Term: CATALYSTS; Subject Term: MOLECULAR weights; Author-Supplied Keyword: CMP-sialic acid synthetases; Author-Supplied Keyword: Sialic acid; Author-Supplied Keyword: Sugar nucleotide; Number of Pages: 9p; Illustrations: 3 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1007/s00253-008-1643-7
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Watkeys, J. M.
AU - Price, L. D.
AU - Upton, P. M.
AU - Maddocks, A.
T1 - The timing of medical examination following an allegation of sexual abuse: is this an emergency?
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2008/10//
VL - 93
IS - 10
M3 - Article
SP - 851
EP - 856
SN - 00039888
AB - Aim: To ascertain the frequency of significant anogenital signs, at medical examination, following an allegation of sexual abuse, in relation to the timing of the examination. Method: A case series of 331 children, who were referred by the police or social services for examination, following an allegation of child sexual abuse or suspicion of this, over a 3 ½-year period in a defined geographical area. Results: Two hundred and fifty-seven children alleged penetrative abuse, of whom 114 were seen within 7 days of the abuse. Twenty-three children alleged penetrative anal abuse within the previous 7 days; 13 of these had abnormal findings (56.5%) compared with 9 (18%) of the 50 children seen more than 7 days after anal abuse. Ninety-two girls alleged penetrative vaginal abuse within the previous 7 days and of these 46(50%) had abnormal findings, compared with 31)30.7%) of the 101 girls seen more than 7 days after the alleged abuse. In addition 33 girls seen within 7 days had other signs associated with probable assault. Abnormal findings were more common in post-pubertal girls. Conclusion: Pubertal and post-pubertal girls are more likely to have significant genital signs if they are examined within 7 days of the last episode of sexual abuse. Our findings suggest that abnormal anal signs are more likely to be present in the acute phase. This study indicates that children should be examined as soon as possible following a referral. This will have implications for clinical practice. Regardless of the lack of accurate history it will always be important to examine the child as soon as possible after disclosure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUALLY abused children
KW - CHILD protection services
KW - CHILDREN -- Medical examinations
KW - SEXUAL abuse victims
KW - CHILD sexual abuse investigation
KW - PERIODIC health examinations
KW - PHYSICIAN practice patterns
KW - MEDICAL social work
KW - SOCIAL work with children
KW - SERVICES for
N1 - Accession Number: 34856490; Watkeys, J. M. 1 Price, L. D. 1 Upton, P. M. 2 Maddocks, A. 3; Email Address: alison.maddocks@nphs.wales.nhs.uk; Affiliation: 1: Department of Child Health. Swansea NHS Trust, Swansea, UK 2: Institute of Health, Social Care, and Psychology, University of Worcester, Worcester, UK 3: National Public Health Service for Wales, Carmarthen, UK; Source Info: Oct2008, Vol. 93 Issue 10, p851; Subject Term: SEXUALLY abused children; Subject Term: CHILD protection services; Subject Term: CHILDREN -- Medical examinations; Subject Term: SEXUAL abuse victims; Subject Term: CHILD sexual abuse investigation; Subject Term: PERIODIC health examinations; Subject Term: PHYSICIAN practice patterns; Subject Term: MEDICAL social work; Subject Term: SOCIAL work with children; Subject Term: SERVICES for; NAICS/Industry Codes: 624110 Child and Youth Services; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 6p; Illustrations: 3 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1136Iadc.2007.123604
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34856490&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
T1 - Detection and characterization of an ABC transporter in Clostridium hathewayi.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2008/10//
VL - 190
IS - 4
M3 - Article
SP - 417
EP - 426
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - An ABC transporter gene from Clostridium hathewayi is characterized. It has duplicated ATPase domains in addition to a transmembrane protein. Its deduced amino acid sequence has conserved functional domains with ATPase components of the multidrug efflux pump genes of several bacteria. Cloning this transporter gene into C. perfringens and E. coli resulted in decreased sensitivities of these bacteria to fluoroquinolones. It also decreased the accumulation and increased the efflux of ethidium bromide from cells containing the cloned gene. Carbonyl cyanide- m-chlorophenylhydrazone (CCCP) inhibited both accumulation and efflux of ethidium bromide from these cells. The ATPase mRNA was overexpressed in the fluoroquinolone-resistant strain when exposed to ciprofloxacin. This is the first report of an ABC transporter in C. hathewayi. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cyanides
KW - Escherichia coli
KW - Genetic engineering
KW - ATP-binding cassette transporters
KW - Clostridium
KW - Amino acids
KW - Bromides
KW - Messenger RNA
KW - Ciprofloxacin
KW - Clostridium hathewayi
KW - Efflux pump
KW - Fluoroquinolone
KW - Resistance
KW - Transporter
N1 - Accession Number: 34406156; Rafii, Fatemeh 1; Email Address: fatemeh.rafii@fda.hhs.gov; Park, Miseon 1; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Issue Info: Oct2008, Vol. 190 Issue 4, p417; Thesaurus Term: Cyanides; Thesaurus Term: Escherichia coli; Thesaurus Term: Genetic engineering; Subject Term: ATP-binding cassette transporters; Subject Term: Clostridium; Subject Term: Amino acids; Subject Term: Bromides; Subject Term: Messenger RNA; Subject Term: Ciprofloxacin; Author-Supplied Keyword: Clostridium hathewayi; Author-Supplied Keyword: Efflux pump; Author-Supplied Keyword: Fluoroquinolone; Author-Supplied Keyword: Resistance; Author-Supplied Keyword: Transporter; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1007/s00203-008-0385-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34406156&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Buehler, Paul W.
AU - Alayash, Abdu I.
T1 - All hemoglobin-based oxygen carriers are not created equally
JO - BBA - Proteins & Proteomics
JF - BBA - Proteins & Proteomics
Y1 - 2008/10//
VL - 1784
IS - 10
M3 - Article
SP - 1378
EP - 1381
SN - 15709639
AB - Abstract: Hemoglobin (Hb)-based oxygen carriers (HBOCs) also known as “blood substitutes” have been under active clinical development over the last two decades. Cell-free Hb outside its natural protective red blood cell environment, as is the case with all HBOCs, has been shown to be vasoactive in part due to the scavenging of vascular endothelial nitric oxide (NO) and may in some instances induce heme-mediated oxidative stress. Chemical modification intended to stabilize HBOCs in the tetrameric or polymeric forms introduces conformational constraints that result in proteins with diverse allosteric responses as well as oxidative and nitrosative redox side reactions. Intra and inter-molecular cross-linking may in some instances also determine the interactions between HBOCs and normal oxidative inactivation and clearance mechanisms. Oxygen and oxidative reactions of normal and several cross-linked Hbs as well as their interactions with endogenous plasma protein (haptoglobin) and cellular receptor pathways (macrophage CD163) differ significantly. Therefore, safety and efficacy may be addressed by designing HBOCs with modifications that limit hypertension, minimize heme destabilization and take into account endogenous Hb removal mechanisms to optimize exposure times for a given indication. [Copyright &y& Elsevier]
AB - Copyright of BBA - Proteins & Proteomics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXYGEN carriers
KW - BLOOD substitutes
KW - ERYTHROCYTES
KW - MEDICAL innovations
KW - OXIDATIVE stress
KW - BLOOD proteins
KW - HAPTOGLOBINS
KW - CHEMICAL modification of proteins
KW - Blood substitutes
KW - Hemoglobin
KW - Nitric oxide
KW - Oxidation
N1 - Accession Number: 34441689; Buehler, Paul W. 1 Alayash, Abdu I.; Email Address: abdu.alayash@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Maryland 20892, USA; Source Info: Oct2008, Vol. 1784 Issue 10, p1378; Subject Term: OXYGEN carriers; Subject Term: BLOOD substitutes; Subject Term: ERYTHROCYTES; Subject Term: MEDICAL innovations; Subject Term: OXIDATIVE stress; Subject Term: BLOOD proteins; Subject Term: HAPTOGLOBINS; Subject Term: CHEMICAL modification of proteins; Author-Supplied Keyword: Blood substitutes; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: Nitric oxide; Author-Supplied Keyword: Oxidation; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.bbapap.2007.12.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34441689&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cooper, Chris E.
AU - Silaghi-Dumitrescu, Radu
AU - Rukengwa, Martine
AU - Alayash, Abdu I.
AU - Buehler, Paul W.
T1 - Peroxidase activity of hemoglobin towards ascorbate and urate: A synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC)
JO - BBA - Proteins & Proteomics
JF - BBA - Proteins & Proteomics
Y1 - 2008/10//
VL - 1784
IS - 10
M3 - Article
SP - 1415
EP - 1420
SN - 15709639
AB - Abstract: Acellular hemoglobins developed as oxygen bridging agents with volume expanding properties (“blood substitutes”) are prone to autoxidation and oxidant-mediated structural changes in circulation. In the presence of hydrogen peroxide and either ascorbate or urate we show that ferric hemoglobin functions as a true enzymatic peroxidase. The activity saturates with both substrates and is linearly dependent on protein concentration. The activity is enhanced at low pH with a pK a of 4.7, consistent with protonation of the ferryl species (Fe(IV)−OH) as the active intermediate. To test whether these redox reactions define its behaviour in vivo we exchanged transfused guinea pigs with 50% polymerized bovine Hb (PolyHbBv) and monitored plasma levels of endogenous ascorbate and urate. Immediately after transfusion, met PolyHbBv levels increased up to 30% of total Hb and remained at this level during the first 24 h post transfusion. Plasma ascorbate decreased by 50% whereas urate levels remained unchanged after transfusion. A simple kinetic model, assuming that ascorbate was a more active ferric heme reductase and peroxidase substrate than urate, was consistent with the in vivo data. The present finding confirms the primary and secondary roles of ascorbate and urate respectively in maintaining the oxidative stability of infused Hb. [Copyright &y& Elsevier]
AB - Copyright of BBA - Proteins & Proteomics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXYGEN carriers
KW - HEMOGLOBIN
KW - HYDROGEN peroxide
KW - PHYSIOLOGICAL oxidation
KW - BLOOD plasma
KW - BLOOD transfusion
KW - ERYTHROCYTES
KW - POLYETHYLENE glycol
KW - Ascorbate
KW - Blood substitute
KW - deoxyhemoglobin ( deoxyHb )
KW - Ferryl
KW - Hemoglobin
KW - hemoglobin ( Hb )
KW - hemoglobin-based oxygen carrier ( HBOC )
KW - methemoglobin ( MetHb )
KW - myoglobin ( Mb )
KW - oxyhemoglobin ( OxyHb )
KW - Peroxidase
KW - polyethylene glycol ( PEG )
KW - polymerized bovine Hb (commercial name Oxyglobin ®), LGO, l-gulonolactone oxidase ( PolyHbBv )
KW - red blood cells ( RBC )
KW - Urate
N1 - Accession Number: 34441726; Cooper, Chris E. 1; Email Address: ccooper@essex.ac.uk Silaghi-Dumitrescu, Radu 1 Rukengwa, Martine 1 Alayash, Abdu I. 2 Buehler, Paul W. 2; Affiliation: 1: Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ UK 2: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA; Source Info: Oct2008, Vol. 1784 Issue 10, p1415; Subject Term: OXYGEN carriers; Subject Term: HEMOGLOBIN; Subject Term: HYDROGEN peroxide; Subject Term: PHYSIOLOGICAL oxidation; Subject Term: BLOOD plasma; Subject Term: BLOOD transfusion; Subject Term: ERYTHROCYTES; Subject Term: POLYETHYLENE glycol; Author-Supplied Keyword: Ascorbate; Author-Supplied Keyword: Blood substitute; Author-Supplied Keyword: deoxyhemoglobin ( deoxyHb ); Author-Supplied Keyword: Ferryl; Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: hemoglobin ( Hb ); Author-Supplied Keyword: hemoglobin-based oxygen carrier ( HBOC ); Author-Supplied Keyword: methemoglobin ( MetHb ); Author-Supplied Keyword: myoglobin ( Mb ); Author-Supplied Keyword: oxyhemoglobin ( OxyHb ); Author-Supplied Keyword: Peroxidase; Author-Supplied Keyword: polyethylene glycol ( PEG ); Author-Supplied Keyword: polymerized bovine Hb (commercial name Oxyglobin ®), LGO, l-gulonolactone oxidase ( PolyHbBv ); Author-Supplied Keyword: red blood cells ( RBC ); Author-Supplied Keyword: Urate; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bbapap.2008.03.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34441726&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Miller, S. A.
AU - Coelho, S. G.
AU - Zmudzka, B. Z.
AU - Bushar, H. F.
AU - Yamaguchi, Y.
AU - Hearing, V. J.
AU - Beer, J. Z.
T1 - Dynamics of pigmentation induction by repeated ultraviolet exposures: dose, dose interval and ultraviolet spectrum dependence.
JO - British Journal of Dermatology
JF - British Journal of Dermatology
Y1 - 2008/10//
VL - 159
IS - 4
M3 - Article
SP - 921
EP - 930
PB - Wiley-Blackwell
SN - 00070963
AB - Background The dynamics of ultraviolet (UV)-induced melanogenesis have been well characterized for single UV exposures. However, our knowledge of the effects of repeated UV exposures on the development of new pigmentation is limited. Objectives To characterize the dynamics and dose dependence of pigmentation induction by repeated UV exposures using two different UV sources. Methods A total of 40 healthy subjects participated in the study: 21 were exposed to a 5% UVB/95% UVA source and 19 were exposed to a 2% UVB/98% UVA source. Skin phototypes 2–3 were represented. Subjects were exposed one to three times per week. The minimal erythemal dose and minimal melanogenic dose of all subjects were determined, and both visual and instrumental observations of the development of pigmentation and erythema were recorded. Results Dark-brown pigmentation could be produced by a cumulative UV dose of 4200 J m−2 given as 10 exposures over 5 weeks. However, comparable pigmentation could also be induced by a cumulative dose of 2900 J m−2 given as eight exposures over 4 weeks. The lowest cumulative dose of 1900 J m−2 given over 4 weeks produced moderate pigmentation. The 2% UVB source led to earlier and darker pigmentation than the 5% UVB source did for equally erythemogenic doses. Conclusions These observations show that the dynamics of melanogenesis induced by repeated exposures depends on UV dose, dose interval and emission spectrum. They also indicate that increasing the UV dose above a certain level of cumulative exposure does not significantly increase the level of UV-induced pigmentation. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - PIGMENTATION disorders
KW - MELANOGENESIS
KW - ULTRAVIOLET radiation
KW - ERYTHEMA
KW - melanogenesis
KW - pigmentation
KW - repeated exposures
KW - ultraviolet radiation
N1 - Accession Number: 34357706; Miller, S. A. 1; Email Address: sharona.miller@fda.hhs.gov Coelho, S. G. 2 Zmudzka, B. Z. 1 Bushar, H. F. 1 Yamaguchi, Y. 2 Hearing, V. J. 2 Beer, J. Z. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, U.S.A. 2: Laboratory of Cell Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20852, U.S.A.; Source Info: Oct2008, Vol. 159 Issue 4, p921; Subject Term: MEDICAL research; Subject Term: PIGMENTATION disorders; Subject Term: MELANOGENESIS; Subject Term: ULTRAVIOLET radiation; Subject Term: ERYTHEMA; Author-Supplied Keyword: melanogenesis; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: repeated exposures; Author-Supplied Keyword: ultraviolet radiation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Illustrations: 1 Color Photograph, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2133.2008.08708.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Girnita, Diana M
AU - Burckart, Gilbert
AU - Zeevi, Adriana
T1 - Effect of cytokine and pharmacogenomic genetic polymorphisms in transplantation
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
Y1 - 2008/10//
VL - 20
IS - 5
M3 - Article
SP - 614
EP - 625
SN - 09527915
AB - Consolidating the information that we have on pharmacogenetics and on cytokine genetics to produce patient-oriented individualized drug regimens is an important challenge in transplantation medicine. Using a multi-variant approach based on genetic profile and other relevant clinical factors a score system may be developed to predict the severity of rejection, infection, or other complications associated with transplantation. The ultimate goal of these studies is to improve patient outcome through individualized drug regimens. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Immunology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - GENETIC polymorphisms
KW - CYTOKINES
KW - TRANSPLANTATION of organs, tissues, etc.
KW - DRUG design
KW - MEDICAL genetics
KW - IMMUNE response
N1 - Accession Number: 34200639; Girnita, Diana M 1 Burckart, Gilbert 2 Zeevi, Adriana 1; Email Address: zeevi@pitt.edu; Affiliation: 1: Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA 15213, United States 2: Office of Clinical Pharmacology, Office of Translational Science, U.S. Food and Drug Administration, Silver Spring, MD 20993, United States; Source Info: Oct2008, Vol. 20 Issue 5, p614; Subject Term: PHARMACOGENOMICS; Subject Term: GENETIC polymorphisms; Subject Term: CYTOKINES; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: DRUG design; Subject Term: MEDICAL genetics; Subject Term: IMMUNE response; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.coi.2008.08.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34200639&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yan, S. Steve
AU - Schreckenberger, Paul C.
AU - Zheng, Xiaotian
AU - Nelson, Nancy A.
AU - Harrington, Susan M.
AU - Tjhio, Joyce
AU - Fedorko, Daniel P.
T1 - An intrinsic pattern of reduced susceptibility to fluoroquinolones in pediatric isolates of Streptococcus pyogenes
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2008/10//
VL - 62
IS - 2
M3 - Article
SP - 205
EP - 209
SN - 07328893
AB - Abstract: A total of 116 clinical isolates collected in 2003 from a tertiary pediatric hospital and a primary pediatric department in Chicago, IL, were screened for reduced susceptibility to selected fluoroquinolones by disc diffusion. Correlation between reduced susceptibility and point mutations in the quinolone resistance-determining region of parC and gyrA genes was evaluated, and point mutations were compared with other reports of isolates derived from adult or mixed patient populations. Nine percent of isolates had reduced susceptibility to 1 or more of these fluoroquinolones by Etest: ciprofloxacin, levofloxacin, and moxifloxacin. A single point mutation (Ser-79) in parC seemed responsible for the reduced susceptibility. Resistant Streptococcus pyogenes isolates were compared using M/emm type, repetitive sequence-based PCR (rep-PCR), and pulsed-field gel electrophoresis (PFGE). Rep-PCR provided no more separation of strains than M/emm typing, and PFGE results with SgrAI were more discriminatory than with SmaI. The majority of these isolates were M/emm type 6. PFGE analysis using SgrAI demonstrated 2 different resistant strains among the M/emm type 6 isolates. The findings suggest that a population of S. pyogenes with an intrinsic reduced susceptibility to fluoroquinolones exists in pediatric clinical isolates. Monitoring of amino acid changes in both parC and gyrA will assist in the prediction of emergence of high-level fluoroquinolone resistance. [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STREPTOCOCCUS
KW - STREPTOCOCCACEAE
KW - ENTEROCOCCUS faecalis
KW - LACTOCOCCUS lactis
KW - Fluoroquinolones
KW - M/emm type
KW - Pediatric isolates
KW - Point mutation
KW - Resistance
KW - Streptococcus pyogenes
N1 - Accession Number: 34439117; Yan, S. Steve 1 Schreckenberger, Paul C. 2 Zheng, Xiaotian 3 Nelson, Nancy A. 4 Harrington, Susan M. 4 Tjhio, Joyce 2 Fedorko, Daniel P. 4; Email Address: dfedorko@mail.cc.nih.gov; Affiliation: 1: Food and Drug Administration, DHHS, Rockville, MD 20855, USA 2: University of Illinois Medical Center, Chicago, IL 60612, USA 3: Children’s Memorial Hospital, Chicago, IL 60614, USA 4: National Institutes of Health Clinical Center, DHHS, Bethesda, MD 20892, USA; Source Info: Oct2008, Vol. 62 Issue 2, p205; Subject Term: STREPTOCOCCUS; Subject Term: STREPTOCOCCACEAE; Subject Term: ENTEROCOCCUS faecalis; Subject Term: LACTOCOCCUS lactis; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: M/emm type; Author-Supplied Keyword: Pediatric isolates; Author-Supplied Keyword: Point mutation; Author-Supplied Keyword: Resistance; Author-Supplied Keyword: Streptococcus pyogenes; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2008.04.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Manjanatha, Mugimane O.
AU - Shelton, Sharon D.
AU - Dobrovoisky, Vasily N.
AU - Shaddock, Joseph O.
AU - McGarrity, Lynda G.
AU - Doerge, Daniel R.
AU - Twaddle, Nathan W.
AU - Chien-Ju Lin
AU - Chen, James J.
AU - Mattison, Donald R.
AU - Morris, Suzanne M.
T1 - Pharmacokinetics, Dose-Range, and Mutagenicity Studies of Methyiphenidate Hydrochloride in B6C3F1 Mice.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/10//
VL - 49
IS - 8
M3 - Article
SP - 585
EP - 593
SN - 08936692
AB - The article reports the results of a pharmacokinetic study in mice conducted to determine the reactive metabolite of methylphenidate hydrochloride (MPH). It also reports the results from the dose-range study that was conducted to determine appropriate doses of MPH for a subsequent genotoxicity study in the liver tissues of transgenic mice. The lack of response to MPH exposure in both of the assays used in the study is consistent with the negative response to MPH exposure reported in the literature using different genotoxicity end points.
KW - Mutagenicity testing
KW - Mutagens
KW - Genetic toxicology
KW - Metabolites
KW - Pharmacokinetics
KW - Mutagenesis
KW - Transgenic mice
KW - Mice as laboratory animals
KW - Preservation of organs, tissues, etc.
KW - Hprt mutation
KW - methyiphenidate hydrochloride
KW - micronucleus assay
KW - ritalinic acid
N1 - Accession Number: 34989025; Manjanatha, Mugimane O. 1; Email Address: mugimane.manjanatha@fda.hhs.gov; Shelton, Sharon D. 1; Dobrovoisky, Vasily N. 1; Shaddock, Joseph O. 1; McGarrity, Lynda G. 1; Doerge, Daniel R. 2; Twaddle, Nathan W. 2; Chien-Ju Lin 3; Chen, James J. 3; Mattison, Donald R. 4; Morris, Suzanne M. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), Jefferson, Arkansas; 2: Division of Biochemical Toxicology, NCTR, FDA, Jefferson, Arkansas; 3: Division of Personalized Medicine and Nutrition, NCTR, FDA, Jefferson, Arkansas; 4: NIH, NICHD, For the Best Pharmaceuticals for Children's Act, Center for Research for Mothers and Children, Bethesda, Maryland; Issue Info: Oct2008, Vol. 49 Issue 8, p585; Thesaurus Term: Mutagenicity testing; Thesaurus Term: Mutagens; Thesaurus Term: Genetic toxicology; Thesaurus Term: Metabolites; Subject Term: Pharmacokinetics; Subject Term: Mutagenesis; Subject Term: Transgenic mice; Subject Term: Mice as laboratory animals; Subject Term: Preservation of organs, tissues, etc.; Author-Supplied Keyword: Hprt mutation; Author-Supplied Keyword: methyiphenidate hydrochloride; Author-Supplied Keyword: micronucleus assay; Author-Supplied Keyword: ritalinic acid; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1002/em.20407
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miura, Daishiro
AU - Dobrovoisky, Vasily N.
AU - Kasahara, Yoshinori
AU - Katsuura, Yasuhiro
AU - HefIkh, Robert H.
T1 - Development of an In Vivo Gene Mutation Assay Using the Endogenous Pig-A Gene: I. Flow Cytometric Detection of CD59-Negotive Peripheral Red Blood Cells and CD48-Negative Spleen 1-Cells From the Rat.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/10//
VL - 49
IS - 8
M3 - Article
SP - 614
EP - 621
SN - 08936692
AB - The article focuses on the development of an in vivo gene mutation assay using the endogenous phosphatidylinositol glycan complementation group A gene (Pig-A). It indicates that Pig-A mutation results in the lack of glycosylphosphatidulinositol synthesis and the absence of GPI-anchored proteins on the cell surface. Anti-CD59 was utilized to detect GPI-anchored proteins on red blood cells (RBCs) and anti-CD48 was used to detect GPI-anchored proteins on spleen T-cells. It concludes that T-cells are a promising tissue for both detecting GPI-deficient cells and confirming that Pig-A gene mutation is the cause of the phenotype.
KW - Mutation (Biology)
KW - Cell membranes
KW - Erythrocytes
KW - Spleen
KW - Rats as laboratory animals
KW - Blood cells
KW - Hematopoietic system
KW - Proteins
KW - Blood
KW - Alexa-488-Iabeled modified proaer- olysin
KW - F344 rats
KW - glycosyiphosphatidylinositol
KW - N-ethyl-N-nitrosourea
N1 - Accession Number: 34989028; Miura, Daishiro 1,2; Dobrovoisky, Vasily N. 1; Kasahara, Yoshinori 2; Katsuura, Yasuhiro 2; HefIkh, Robert H. 1; Email Address: robert.heflich@fda.hhs.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas; 2: TEUIN Pharma Limited, Tokyo, Japan; Issue Info: Oct2008, Vol. 49 Issue 8, p614; Thesaurus Term: Mutation (Biology); Thesaurus Term: Cell membranes; Subject Term: Erythrocytes; Subject Term: Spleen; Subject Term: Rats as laboratory animals; Subject Term: Blood cells; Subject Term: Hematopoietic system; Subject Term: Proteins; Subject Term: Blood; Author-Supplied Keyword: Alexa-488-Iabeled modified proaer- olysin; Author-Supplied Keyword: F344 rats; Author-Supplied Keyword: glycosyiphosphatidylinositol; Author-Supplied Keyword: N-ethyl-N-nitrosourea; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1002/eni.20414
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34989028&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Miura, Daishiro
AU - Dobrovolsky, Vasily N.
AU - Mittelstaedt, Roberta A.
AU - Kasahara, Yoshinori
AU - Katsuura, Yasuhiro
AU - Heflich, Robert H.
T1 - Development of an In Vivo Gene Mutation Assay Using the Endogenous Pig-A Gene: II. Selection of Pig-A Mutant Rat Spleen 1-Cells With Proaerolysin and Sequencing Pig-A cDNA From the Mutants.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/10//
VL - 49
IS - 8
M3 - Article
SP - 622
EP - 630
SN - 08936692
AB - The article reports that rat spleen T-cells and peripheral red blood cells that are deficient in glycosylphosphatidylinositol (GPI) synthesis could be detected by flow cytometry as cells negative for GPI-linked markers. It examines GPI-deficient spleen T-cells for Pig-A mutations by establishing a clonal assay using proaerolysin selection. It continues the development of a rapid in vivo mutation assay based on quantifying GPI-deficinet cells by examining the mutational basis of the phenotype. It develops a method for the selection and expansion of GPI-deficient rat spleen T-cells.
KW - Mutation (Biology)
KW - Cell membranes
KW - Erythrocytes
KW - Spleen
KW - Rats as laboratory animals
KW - Blood cells
KW - Hematopoietic system
KW - Proteins
KW - Blood
KW - aerolysin
KW - CD48; F344 rots
KW - flow cytometry
KW - glycosyiphosphotidylinositol
KW - N-ethyl-N-nitrosourea
N1 - Accession Number: 34989029; Miura, Daishiro 1,2; Dobrovolsky, Vasily N. 1; Mittelstaedt, Roberta A. 1; Kasahara, Yoshinori 2; Katsuura, Yasuhiro 2; Heflich, Robert H. 1; Email Address: robert.heflich@fda.hhs.gov; Affiliations: 1: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas; 2: TEUIN Pharma Limited, Tokyo, Japan; Issue Info: Oct2008, Vol. 49 Issue 8, p622; Thesaurus Term: Mutation (Biology); Thesaurus Term: Cell membranes; Subject Term: Erythrocytes; Subject Term: Spleen; Subject Term: Rats as laboratory animals; Subject Term: Blood cells; Subject Term: Hematopoietic system; Subject Term: Proteins; Subject Term: Blood; Author-Supplied Keyword: aerolysin; Author-Supplied Keyword: CD48; F344 rots; Author-Supplied Keyword: flow cytometry; Author-Supplied Keyword: glycosyiphosphotidylinositol; Author-Supplied Keyword: N-ethyl-N-nitrosourea; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1002/em.20413
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Reynisson, Jóhannes
AU - Stiborová, Marie
AU - MartInek, Václav
AU - Gamboa da Costa, Goncalo
AU - Phillips, David H.
AU - Arlt, Volker M.
T1 - Mutagenic Potential of Nitrenium Ions of Nitrobenzanthrones: Correlation Between Theory and Experiment.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/10//
VL - 49
IS - 8
M3 - Article
SP - 659
EP - 667
SN - 08936692
AB - The article investigates the mutagenic potential of nitrenium ions of nitrobenzanthrones (NBA). The calculated properties of the NBA derivatives were systematically compared with their bacterial mutagenic potency. It shows that accommodation of the ligand substrates into the binding pocket of the bacterial nitroreductases was not sterically inhibited for the NBAs. A strong negative linear correlation was found when the relative energies of the nitrenium ions of the mono and disubstituted NBAs were plotted against the logarithm of the mutagenic potency of the NBAs found in the different Salmonella typhimurium strains.
KW - Ions
KW - Salmonella
KW - Enterobacteriaceae
KW - Bacteria
KW - Mutagenesis
KW - Salmonella typhimurium
KW - Density functionals
KW - Ligands (Biochemistry)
KW - Electrons
KW - 3-nitrobenzanthrone
KW - density functional theory
KW - mutogenicity
KW - nitrenium ion
N1 - Accession Number: 34989032; Reynisson, Jóhannes 1; Stiborová, Marie 2; MartInek, Václav 2; Gamboa da Costa, Goncalo 3; Phillips, David H. 4; Arlt, Volker M. 4; Email Address: volker.arlt@icr.ac.uk; Affiliations: 1: School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom; 2: Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic; 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; 4: Section of Molecular Corcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom; Issue Info: Oct2008, Vol. 49 Issue 8, p659; Thesaurus Term: Ions; Thesaurus Term: Salmonella; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Bacteria; Subject Term: Mutagenesis; Subject Term: Salmonella typhimurium; Subject Term: Density functionals; Subject Term: Ligands (Biochemistry); Subject Term: Electrons; Author-Supplied Keyword: 3-nitrobenzanthrone; Author-Supplied Keyword: density functional theory; Author-Supplied Keyword: mutogenicity; Author-Supplied Keyword: nitrenium ion; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1002/em.20411
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Levin, Ronnie
AU - Brown, Mary Jean
AU - Kashtock, Michael E.
AU - Jacobs, David E.
AU - Whelan, Elizabeth A.
AU - Rodman, Joanne
AU - Schock, Michael R.
AU - Padilla, Alma
AU - Sinks, Thomas
T1 - Lead Exposures in U.S. Children, 2008: Implications for Prevention.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/10//
VL - 116
IS - 10
M3 - Article
SP - 1285
EP - 1293
PB - Superintendent of Documents
SN - 00916765
AB - OBJECTIVE: We reviewed the sources of lead in the environments of U.S. children, contributions to children's blood lead levels, source elimination and control efforts, and existing federal authorities. Our context is the U.S. public health goal to eliminate pediatric elevated blood lead levels (EBLs) by 2010. DATA SOURCES: National, state, and local exposure assessments over the past half century have identified risk factors for EBLs among U.S. children, including age, race, income, age and location of housing, parental occupation, and season. DATA EXTRACTION AND SYNTHESIS: Recent national policies have greatly reduced lead exposure among U.S. children, but even very low exposure levels compromise children's later intellectual development and lifetime achievement. No threshold for these effects has been demonstrated. Although lead paint and dust may still account for up to 70% of EBLs in U.S. children, the U.S. Centers for Disease Control and Prevention estimates that ≥ 30% of current EBLs do not have an immediate lead paint source, and numerous studies indicate that lead exposures result from multiple sources. EBLs and even deaths have been associated with inadequately controlled sources including ethnic remedies and goods, consumer products, and food-related items such as ceramics. Lead in public drinking water and in older urban centers remain exposure sources in many areas. CONCLUSIONS: Achieving the 2010 goal requires maintaining current efforts, especially programs addressing lead paint, while developing interventions that prevent exposure before children are poisoned. It also requires active collaboration across all levels of government to identify and control all potential sources of lead exposure, as well as primary prevention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH
KW - Health risk assessment
KW - Hazardous substances -- Risk assessment
KW - Environmental exposure
KW - Drinking water -- Lead content
KW - Lead based paint
KW - Lead poisoning in children -- Prevention
KW - Children
KW - Blood analysis
KW - Lead abatement -- Law & legislation
KW - United States
KW - children's health
KW - environmental health
KW - lead poisoning
KW - primary prevention
KW - Centers for Disease Control & Prevention (U.S.)
N1 - Accession Number: 34994628; Levin, Ronnie 1; Email Address: levin.ronnie@epa.gov; Brown, Mary Jean 2; Kashtock, Michael E. 3; Jacobs, David E. 4; Whelan, Elizabeth A. 5; Rodman, Joanne 6; Schock, Michael R. 7; Padilla, Alma 1; Sinks, Thomas 2; Affiliations: 1: U.S. Environmental Protection Agency, Boston, Massachusetts, USA; 2: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: Food and Drug Administration, Washington, DC, USA; 4: Department of Housing and Urban Development, Washington, DC, USA; 5: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 6: U.S. Environmental Protection Agency, Washington, DC, USA; 7: U.S. Environmental Protection Agency, Cincinnati, Ohio, USA; Issue Info: Oct2008, Vol. 116 Issue 10, p1285; Thesaurus Term: HEALTH; Thesaurus Term: Health risk assessment; Thesaurus Term: Hazardous substances -- Risk assessment; Thesaurus Term: Environmental exposure; Thesaurus Term: Drinking water -- Lead content; Thesaurus Term: Lead based paint; Subject Term: Lead poisoning in children -- Prevention; Subject Term: Children; Subject Term: Blood analysis; Subject Term: Lead abatement -- Law & legislation; Subject: United States; Author-Supplied Keyword: children's health; Author-Supplied Keyword: environmental health; Author-Supplied Keyword: lead poisoning; Author-Supplied Keyword: primary prevention ; Company/Entity: Centers for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 9p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Jong-Kyung
AU - Jung, Da-Wa
AU - Eom, So-Youn
AU - Oh, Se-Wook
AU - Kim, Yunji
AU - Kwak, Hyo-Sun
AU - Kim, Young-Ho
T1 - Occurrence of Vibrio parahaemolyticus in oysters from Korean retail outlets
JO - Food Control
JF - Food Control
Y1 - 2008/10//
VL - 19
IS - 10
M3 - Article
SP - 990
EP - 994
SN - 09567135
AB - Abstract: The occurrence of Vibrio parahaemolyticus in 72 samples of raw Korean oysters obtained monthly from April to December from retail outlets was monitored, and the virulence of the strains isolated from 48 oyster samples investigated. V. parahaemolyticus was isolated in oysters from May to November with the highest level in August and September. Multiplex PCR showed that none of the V. parahaemolyticus strains isolated contained the gene for thermostable direct haemolysin (tdh), although one strain was positive for TDH-related haemolysin (trh). These data can be utilized for a risk-management plan to establish Food Safety Objectives (FSO) for V. parahaemolyticus in oysters at retail outlets in Korea. [Copyright &y& Elsevier]
AB - Copyright of Food Control is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD industry
KW - FOOD handling
KW - HOUSEHOLD sanitation
KW - FOOD -- Safety measures
KW - Korea
KW - PCR amplification
KW - Retail oysters
KW - Vibrio parahaemolyticus
N1 - Accession Number: 32074139; Lee, Jong-Kyung 1; Email Address: jklee@kfri.re.kr Jung, Da-Wa 1 Eom, So-Youn 1 Oh, Se-Wook 1 Kim, Yunji 1 Kwak, Hyo-Sun 2 Kim, Young-Ho 1; Affiliation: 1: Korea Food Research Institute, San 46-1, Baekhyun-dong, Bundang-gu, Seongnam-si, Kyunggi-do 463-420, Republic of Korea 2: Korea Food and Drug Administration, #5, Nokbun-dong, Eunpyeong-gu, Seoul 122-824, Republic of Korea; Source Info: Oct2008, Vol. 19 Issue 10, p990; Subject Term: FOOD industry; Subject Term: FOOD handling; Subject Term: HOUSEHOLD sanitation; Subject Term: FOOD -- Safety measures; Author-Supplied Keyword: Korea; Author-Supplied Keyword: PCR amplification; Author-Supplied Keyword: Retail oysters; Author-Supplied Keyword: Vibrio parahaemolyticus; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 561720 Janitorial Services; NAICS/Industry Codes: 561722 Janitorial services (except window cleaning); Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodcont.2007.10.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105606829
T1 - Comparison of Web-based versus paper-and-pencil self-administered questionnaire: effects on health indicators in Dutch adolescents.
AU - van de Looij-Jansen PM
AU - de Wilde EJ
Y1 - 2008/10//
N1 - Accession Number: 105606829. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Instrumentation: Child Health Questionnaire (CHQ); Rosenberg Self-Esteem Scale; Strengths and Difficulties Questionnaire (SDQ). NLM UID: 0053006.
KW - Data Collection Methods
KW - Internet
KW - Mental Health -- In Adolescence -- Netherlands
KW - Questionnaires -- Utilization
KW - Adolescence
KW - Alcohol Drinking
KW - Analysis of Covariance
KW - Cannabis
KW - Female
KW - Male
KW - Mann-Whitney U Test
KW - Netherlands
KW - Privacy and Confidentiality
KW - Psychological Tests
KW - Questionnaires
KW - Random Assignment
KW - Rosenberg Self Esteem Scale
KW - Sexuality
KW - Smoking
KW - Substance Abuse
KW - Human
SP - 1708
EP - 1721
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 43
IS - 5p1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Youth Department, Municipal Public Health Service for the Rotterdam Area, Rotterdam, The Netherlands
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Valerio Jr, L. G.
T1 - Tools for evidence-based toxicology: computational-based strategies as a viable modality for decision support in chemical safety evaluation and risk assessment.
JO - Human & Experimental Toxicology
JF - Human & Experimental Toxicology
Y1 - 2008/10//
VL - 27
IS - 10
M3 - Article
SP - 757
EP - 760
PB - Sage Publications, Ltd.
SN - 09603271
AB - The article focuses on issues related to toxicology involving chemical safety evaluation and risk assessment. It notes on the concept of evidence-based toxicology (EBT) which represents a foundation in providing an advanced philosophic approach to causation. It mentions the globally-accepted practice known as evidence-based medicine (EMB) in which the EBT has derived its principals. It notes on the advantage of computational-based strategies such as quantitative structure-activity relationship (QSAR) predictive toxicological modeling due to technological advances contributed by modern computer for experiments and clinical trials of xenobiotics.
KW - MEDICINE
KW - PHARMACOLOGY
KW - EVIDENCE-based medicine
KW - MEDICAL experimentation on humans
KW - STRUCTURE-activity relationships (Biochemistry)
KW - QSAR (Biochemistry)
KW - MEDICAL sciences
KW - CLINICAL chemistry
KW - BIOCHEMICAL toxicology
KW - causation
KW - chemical risk assessment
KW - computational toxicology
KW - evidence-based toxicology
KW - in silico toxicology
KW - safety evaluation
N1 - Accession Number: 35790260; Valerio Jr, L. G. 1; Email Address: Luis.Valerio@fda.hhs.gov; Affiliation: 1: Informatics and Computational Safety Analysis Staff, Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland USA; Source Info: Oct2008, Vol. 27 Issue 10, p757; Subject Term: MEDICINE; Subject Term: PHARMACOLOGY; Subject Term: EVIDENCE-based medicine; Subject Term: MEDICAL experimentation on humans; Subject Term: STRUCTURE-activity relationships (Biochemistry); Subject Term: QSAR (Biochemistry); Subject Term: MEDICAL sciences; Subject Term: CLINICAL chemistry; Subject Term: BIOCHEMICAL toxicology; Author-Supplied Keyword: causation; Author-Supplied Keyword: chemical risk assessment; Author-Supplied Keyword: computational toxicology; Author-Supplied Keyword: evidence-based toxicology; Author-Supplied Keyword: in silico toxicology; Author-Supplied Keyword: safety evaluation; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ham, J. E.
AU - Wells, J. R.
T1 - Surface chemistry reactions of α-terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone and air on a glass and a vinyl tile.
JO - Indoor Air
JF - Indoor Air
Y1 - 2008/10//
VL - 18
IS - 5
M3 - Article
SP - 394
EP - 407
PB - Wiley-Blackwell
SN - 09056947
AB - The surface-phase reaction products of α-terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone (O3), air or nitrogen (N2) on both a glass and vinyl flooring tile were investigated using the recently published FLEC Automation and Control System (FACS). The FACS was used to deliver O3 (100 ppb), air or N2 to the surface at a specified flow rate (300 ml/min) and relative humidity (50%) after application of a 1.6%α-terpineol solution in methanol. Oxidation products were detected using the derivatization agents: O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine and N,O-bis(trimethysilyl)trifluoroacetamide. The positively identified reaction products were glyoxal, methylglyoxal and 4-oxopentanal. The proposed oxidation products based on previously published VOC/O3 reaction mechanisms were: 4-methylcyclohex-3-en-1-one, 6-hydroxyhept-en-2-one, 3-(1-hydroxy-1-methylethyl)-6-methylcyclohex-2-en-1-one) and one surface-enhanced reaction product: 5-(1-hydroxy-1-methylethyl)-2-methylcyclohex-2-en-1-one. Though similar products were observed in gas-phase α-terpineol/O3 reactions, the ratio of the reaction products were different suggesting stabilization of larger molecular weight species by the surface. Emission profiles of these oxidation products over 72 h are also reported. Practical Implications Volatile organic compounds (VOCs) can interact with indoor initiators [such as hydroxyl radicals (OH•), ozone and nitrate radicals (NO3•)] to form a number of oxygenated by-products in the gas-phase. However, when VOCs are applied to or are present on the surface, heterogeneous chemistry with indoor initiators can also occur. The surface can influence the reaction mechanism to produce new surface reaction products. The work, described here, shows the interaction of α-terpineol (major component of pine oil) with ozone and air on both glass and vinyl flooring. These results demonstrated emissions of oxygenated organic compounds as a result of reaction and that further investigations of this chemistry are required to accurately estimate indoor occupant exposures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ozone
KW - Surface chemistry
KW - Isopropyl alcohol
KW - Glass
KW - Hydroxylamine
KW - Chemical reactions
KW - α-Terpineol
KW - α-Terpineol
KW - Reaction products
N1 - Accession Number: 34293635; Ham, J. E. 1; Email Address: bvo2@cdc.gov; Wells, J. R. 1; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Issue Info: Oct2008, Vol. 18 Issue 5, p394; Thesaurus Term: Ozone; Thesaurus Term: Surface chemistry; Subject Term: Isopropyl alcohol; Subject Term: Glass; Subject Term: Hydroxylamine; Subject Term: Chemical reactions; Author-Supplied Keyword: α-Terpineol; Author-Supplied Keyword: α-Terpineol; Author-Supplied Keyword: Reaction products; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 416340 Paint, glass and wallpaper merchant wholesalers; NAICS/Industry Codes: 238150 Glass and Glazing Contractors; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 14p; Illustrations: 2 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2008.00540.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Suda, Megumi
AU - Honma, Takeshi
AU - Miyagawa, Muneyuki
AU - Rui-Sheng Wang
T1 - Alteration of Brain Levels of Neurotransmitters and Amino Acids in Male F344 Rats Induced by Three-week Repeated Inhalation Exposure to 1-Bromopropane.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/10//
VL - 46
IS - 4
M3 - Article
SP - 348
EP - 359
SN - 00198366
AB - The article presents a study on the effects of 1-bromopropane (1BP) on brain neuro-active substances of rats to distinguish the extent of its toxicity to the central nervous system (CNS). It sees the changes in neurotransmitters and the metabolites in brain which followed the inhalation exposure to 1BP. The results revealed significant changes in amino acid contents of rat brains.
KW - Metabolites
KW - Bromopropane
KW - Amino acids
KW - Neurosciences
KW - Central nervous system
KW - 1-Bromopropane
KW - Acetylcholine
KW - Catecholamine
KW - Neurotransmitter
KW - Rat brain
KW - Serotonin
KW - Toxicity
N1 - Accession Number: 35945295; Suda, Megumi 1; Honma, Takeshi 2; Miyagawa, Muneyuki 1; Rui-Sheng Wang 1; Affiliations: 1: National Institute of Occupational Safety and Health (JNIOSH), Nagao 6-21-1, Tama-ku, Kawasaki 214- 8585, Japan; 2: Japan Association for Working Environment Measurement, Shiba 4-4-5, Minato-ku, Tokyo 108-8372, Japan; Issue Info: 2008, Vol. 46 Issue 4, p348; Thesaurus Term: Metabolites; Subject Term: Bromopropane; Subject Term: Amino acids; Subject Term: Neurosciences; Subject Term: Central nervous system; Author-Supplied Keyword: 1-Bromopropane; Author-Supplied Keyword: Acetylcholine; Author-Supplied Keyword: Catecholamine; Author-Supplied Keyword: Neurotransmitter; Author-Supplied Keyword: Rat brain; Author-Supplied Keyword: Serotonin; Author-Supplied Keyword: Toxicity; Number of Pages: 12p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105571345
T1 - Physical victimization in prison: the role of mental illness.
AU - Blitz CL
AU - Wolff N
AU - Shi J
AU - Blitz, Cynthia L
AU - Wolff, Nancy
AU - Shi, Jing
Y1 - 2008/10//
N1 - Accession Number: 105571345. Language: English. Entry Date: 20090130. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Special Interest: Psychiatry/Psychology. Grant Information: P20 MH066170-05/MH/NIMH NIH HHS/United States. NLM UID: 7806862.
KW - Crime Victims -- Psychosocial Factors
KW - Mental Disorders -- Psychosocial Factors
KW - Prisoners -- Psychosocial Factors
KW - Violence -- Psychosocial Factors
KW - Adult
KW - Correctional Facilities
KW - Crime Victims -- Statistics and Numerical Data
KW - Data Collection
KW - Ethnic Groups -- Psychosocial Factors
KW - Ethnic Groups -- Statistics and Numerical Data
KW - Female
KW - Male
KW - Mental Disorders -- Epidemiology
KW - Prevalence
KW - Prisoners -- Statistics and Numerical Data
KW - Questionnaires
KW - Risk Factors
KW - Sex Factors
KW - Sexual Abuse
KW - Violence
KW - Human
SP - 385
EP - 393
JO - International Journal of Law & Psychiatry
JF - International Journal of Law & Psychiatry
JA - INT J LAW PSYCHIATRY
VL - 31
IS - 5
PB - Pergamon Press - An Imprint of Elsevier Science
AB - This study compares prison physical victimization rates (inmate-on-inmate and staff-on-inmate) for people with mental disorder to those without mental disorder in a state prison system. Inmate subjects were drawn from 14 adult prisons operated by a single mid-Atlantic State. A sample of 7,528 subjects aged 18 or older (7,221 men and 564 women) completed an audio-computer administered survey instrument. Mental disorder was based on self-reported mental health treatment ever for particular mental disorders. Approximately one-quarter of the sample reported some prior treatment for schizophrenia, bipolar disorder, depression, PTSD, or anxiety disorder. Rates of physical victimization for males with any mental disorder were 1.6 times (inmate-on-inmate) and 1.2 times (staff-on-inmate) higher than that of males with no mental disorder. Female inmates with mental disorder were 1.7 times more likely to report being physically victimized by another inmate than did their counterparts with no mental disorder. Overall, both males and females with mental disorder are disproportionately represented among victims of physical violence inside prison.
SN - 0160-2527
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, N.J., USA
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, N.J., USA. clblitz@rci.rutgers.edu
U2 - PMID: 18809210.
DO - 10.1016/j.ijlp.2008.08.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105571345&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ritschel, Wolfgang A.
AU - Ye, Wei
AU - Buhse, Lucinda
AU - Reepmeyer, John C.
T1 - Stability of the nitrogen mustard mechlorethamine in novel formulations for dermatological use
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2008/10//
VL - 362
IS - 1/2
M3 - Article
SP - 67
EP - 73
SN - 03785173
AB - Abstract: Long term stability measurements were made for the nitrogen mustard mechlorethamine HCl at a concentration of 0.02% in six topical formulations: Aquaphor® ointment, Transcutol®, Labrasol®, 10% Transcutol® in Aquaphor®, 10% Transcutol® in Labrasol®, and Aquaphilic® ointment. The drug decomposed gradually in Aquaphor® ointment at room temperature, dropping to 95% in 4 weeks, 85% in 12 weeks, and 78% in 39 weeks. On the other hand, the drug decomposed rapidly in Aquaphilic® ointment, giving an assay of less than 20% of its initial concentration after 24h at room temperature. Generally, mechlorethamine HCl was more stable in Aquaphor® ointment than in formulations containing Transcutol® or Labrasol®. However, the addition of the free radical inhibitor, BHT, significantly enhanced the stability of mechlorethamine in Transcutol® and Labrasol® formulations. Four BHT-stabilized Transcutol® and Labrasol® formulations gave assays in ranges of 92–99% at the end of 4 weeks, 77–98% at the end of 12 weeks, and 38–93% at the end of 41 weeks. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NITROGEN mustards
KW - DERMATOLOGY
KW - OINTMENTS
KW - ALKYLATING agents
KW - Aquaphor®
KW - Dermal delivery
KW - Mechlorethamine
KW - Nitrogen mustard
KW - Stability
KW - Transcutol®
N1 - Accession Number: 34090642; Ritschel, Wolfgang A. 1 Ye, Wei 2 Buhse, Lucinda 2 Reepmeyer, John C. 2; Email Address: john.reepmeyer@fda.hhs.gov; Affiliation: 1: University of Cincinnati Medical Center, The James L. Winkle College of Pharmacy and College of Medicine, Department of Pharmacology and Cell Biophysics, 3223 Eden Ave., ML 0004, Cincinnati, OH 45267, USA 2: United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA; Source Info: Oct2008, Vol. 362 Issue 1/2, p67; Subject Term: NITROGEN mustards; Subject Term: DERMATOLOGY; Subject Term: OINTMENTS; Subject Term: ALKYLATING agents; Author-Supplied Keyword: Aquaphor®; Author-Supplied Keyword: Dermal delivery; Author-Supplied Keyword: Mechlorethamine; Author-Supplied Keyword: Nitrogen mustard; Author-Supplied Keyword: Stability; Author-Supplied Keyword: Transcutol®; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ijpharm.2008.06.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34090642&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rozenbaum, M. H.
AU - Verweel, G.
AU - Folkerts, D. K. F.
AU - Dronkers, F.
AU - Van den Hoek, J. A. R.
AU - Hartwig, N. G.
AU - de Groot, R.
AU - Postma, M. J.
T1 - Cost-effectiveness estimates for antenatal HIV testing in the Netherlands.
JO - International Journal of STD & AIDS
JF - International Journal of STD & AIDS
Y1 - 2008/10//
VL - 19
IS - 10
M3 - Article
SP - 668
EP - 675
PB - Sage Publications, Ltd.
SN - 09564624
AB - This paper provides an estimation of the lifetime health-care cost of HIV-infected children and an update of the costeffectiveness of universal HIV-screening of pregnant women in Amsterdam (The Netherlands). During 2003-2005, we collected data concerning the prevalence of newly diagnosed HIV-infected pregnant women in Amsterdam. Also, data on resource utilization and HAART regimen for HIV-infected children was gathered from a national registry. Using Kaplan-Meier survival analysis, we estimated the life-expectancy of a vertically HIV-infected child at 19 years, with the corresponding lifetime health-care costs of €179,974. HIVscreening of pregnant women could prevent 2.4 HIV transmissions annually in Amsterdam, based on an estimated prevalence of nine yet undiagnosed HIV-positive pregnant women per 10,000 pregnancies. We show that universal HIV screening during pregnancy generates significant net cost savings and health benefits in most situations. Universal antenatal HIV screening is justified in Amsterdam from a health-economic point of view. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of STD & AIDS is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Medical care costs
KW - HIV-positive persons
KW - HIV infections -- Transmission
KW - Pregnancy complications
KW - Pregnant women
KW - Medical screening
KW - Highly active antiretroviral therapy
KW - Amsterdam (Netherlands)
KW - Netherlands
KW - AIDS
KW - antenatal HIV-screening
KW - cost-effectiveness analyses
KW - health economics
KW - mother-to-child transmission
N1 - Accession Number: 42734666; Rozenbaum, M. H. 1; Verweel, G. 2; Folkerts, D. K. F. 3; Dronkers, F. 1; Van den Hoek, J. A. R. 3,4; Hartwig, N. G. 2; de Groot, R. 5; Postma, M. J. 2,6; Email Address: m.j.postma@rug.nl; Affiliations: 1: Department of Pharmacy, University of Groningen, Groningen, The Netherlands; 2: Department of Immunology, Erasmus Medical Centre, Rotterdam, The Netherlands; 3: Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands; 4: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine & AIDS, Academic Medical Centre, Amsterdam, The Netherlands; 5: Department of Pediatrics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; 6: Department of Epidemiology, University Medical Centre Groningen, Groningen, The Netherlands; Issue Info: Oct2008, Vol. 19 Issue 10, p668; Subject Term: Medical care costs; Subject Term: HIV-positive persons; Subject Term: HIV infections -- Transmission; Subject Term: Pregnancy complications; Subject Term: Pregnant women; Subject Term: Medical screening; Subject Term: Highly active antiretroviral therapy; Subject: Amsterdam (Netherlands); Subject: Netherlands; Author-Supplied Keyword: AIDS; Author-Supplied Keyword: antenatal HIV-screening; Author-Supplied Keyword: cost-effectiveness analyses; Author-Supplied Keyword: health economics; Author-Supplied Keyword: mother-to-child transmission; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1258/ijsa.2008.008077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=42734666&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105711083
T1 - Sounding board. PAs, health literacy, and medication safety.
AU - Clancy C
Y1 - 2008/10//2008 Oct
N1 - Accession Number: 105711083. Language: English. Entry Date: 20081212. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9513102.
KW - Literacy
KW - Medication Errors -- Prevention and Control
KW - Patient Safety
KW - Physician Assistants
KW - Health Literacy
KW - United States Agency for Healthcare Research and Quality
SP - 51
EP - 51
JO - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JF - JAAPA: Journal of the American Academy of Physician Assistants (Haymarket Media, Inc.)
JA - JAAPA J AM ACAD PHYSICIAN ASSIST
VL - 21
IS - 10
CY - New York, New York
PB - Haymarket Media, Inc.
SN - 1547-1896
AD - Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 19024637.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105711083&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lincoln, J.
AU - Lucas, D.
T1 - Commercial Fishing Fatalities-- California, Oregon, and Washington, 2000-2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/10//10/1/2008
VL - 300
IS - 13
M3 - Article
SP - 1510
EP - 1511
SN - 00987484
AB - The article presents a report from the U.S. Centers for Disease Control and Prevention (CDC) on commercial fishing fatalities for California, Oregon, and Washington for the years 2000-2006. The CDC analyzed data on the fatalities to determine whether safety interventions were needed for the Pacific Northwest states. Results showed that the annual fishing fatality rate was double the fishing fatality rate nationwide for the same period. It was found that safety equipment had not been used adequately. Additional prevention measures designed to protect those at greatest risk, the Northwest Dungeness crab fishermen, are needed. Statistics are included on the causes for fatalities and the safety measures available at the time of each fatality.
KW - FISHING accidents
KW - OCCUPATIONAL mortality
KW - ACCIDENTS -- Research
KW - OCCUPATIONAL hazards
KW - CRAB fisheries
KW - NORTHWEST, Pacific
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 34570959; Lincoln, J. 1 Lucas, D. 1; Affiliation: 1: Alaska Pacific Regional Office, National Institute for Occupational Safety and Health, CDC; Source Info: 10/1/2008, Vol. 300 Issue 13, p1510; Subject Term: FISHING accidents; Subject Term: OCCUPATIONAL mortality; Subject Term: ACCIDENTS -- Research; Subject Term: OCCUPATIONAL hazards; Subject Term: CRAB fisheries; Subject Term: NORTHWEST, Pacific; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 112512 Shellfish Farming; Number of Pages: 2p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34570959&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - T. J., Miller
AU - A., Knapton
AU - O., Adeyemo
AU - L., Noory
AU - J., Weaver
AU - P., Hanig J.
T1 - Cytochrome C: a non-invasive biomarker of drug-induced liver injury.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2008/10//
VL - 28
IS - 7
M3 - Article
SP - 815
EP - 828
SN - 0260437X
AB - The article presents a study which evaluates the use of cytochrome c (cyt c) as a non-invasive biomarker of drug-induced liver injury. It states that the study was undertaken to emphasize the need for additional tools in detecting human toxicity. The study used the urine of adult rats treated with hepatoxins as subject of the experiment and employed serum diagnostic tests, immunohistochemistry, and urinary analysis for cyt c. Results indicated histomorphological changes and TUNEL staining in liver coherent with hepatocellular necrosis, apoptosis, and inflammation and showed that the liver is the primary source of cyt c. It shows that cyt c is a useful indicator of hepatic injury when used as a potential urinary biomarker.
KW - Biochemical markers
KW - Bioindicators
KW - Apoptosis
KW - Cytochrome c
KW - Liver diseases
KW - Urinalysis
KW - Hepatotoxicology
KW - Serodiagnosis
KW - Diagnostic immunohistochemistry
KW - apoptosis
KW - biomarker
KW - cytochrome C
KW - hepatotoxicity
KW - liver
KW - mitochondria
KW - urinary biomarker
N1 - Accession Number: 34917117; T. J., Miller 1; Email Address: terry.miIIer@fda.hhs.gov; A., Knapton 1; O., Adeyemo 1; L., Noory 1; J., Weaver 1; P., Hanig J. 1; Affiliations: 1: Division of Applied Pharmacology Research. Center for Drug Evaluation and Research, Food and Drug Administration. Silver Spring, Maryland, USA; Issue Info: Oct2008, Vol. 28 Issue 7, p815; Thesaurus Term: Biochemical markers; Thesaurus Term: Bioindicators; Thesaurus Term: Apoptosis; Subject Term: Cytochrome c; Subject Term: Liver diseases; Subject Term: Urinalysis; Subject Term: Hepatotoxicology; Subject Term: Serodiagnosis; Subject Term: Diagnostic immunohistochemistry; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: biomarker; Author-Supplied Keyword: cytochrome C; Author-Supplied Keyword: hepatotoxicity; Author-Supplied Keyword: liver; Author-Supplied Keyword: mitochondria; Author-Supplied Keyword: urinary biomarker; Number of Pages: 14p; Illustrations: 3 Color Photographs, 1 Chart, 12 Graphs; Document Type: Article
L3 - 10.1002/jat.1347
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34917117&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Knudsen, J. F.
AU - Sokol, G. H.
AU - Flowers, C. M.
T1 - Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2008/10//
VL - 33
IS - 5
M3 - Article
SP - 513
EP - 519
PB - Wiley-Blackwell
SN - 02694727
AB - Background: Topiramate was approved for the treatment of epilepsy in 1999 and has since been approved for the prevention of migraine headache. It is structurally different from the majority of antiepileptic medications and is pharmacodynamically unique in its ability to inhibit the enzyme carbonic anhydrase. Postmarketing reports of topiramate-associated hypothermia have occurred but this adverse event has not been well characterized. Data mining of an adverse event database was used to assist in the identification of hypothermia. Objective: We sought to explore a possible association between the concomitant use of topiramate and valproic acid and the induction of hypothermia. Methods: This was a pharmacovigilance case series survey of spontaneous hypothermia, a reported adverse event in patients treated with topiramate and valproic acid, alone and in combination. The U.S. Food and Drug Administration’s Adverse Events Reporting System (AERS) database was searched for reports of hypothermia in association with the use of topiramate. A data mining algorithm was used on the AERS to identify scores for hypothermia associated with antiepileptic drugs. Results: We identified 22 unduplicated reports of hypothermia in patients exposed to topiramate. Three of the 22 were confounded by patient overdoses with multiple drugs and not considered. Use of more than one antiepileptic drug was reported in most of the remaining 19 reports. Of these 19 reports, valproic acid was mentioned in 7. Two of the 19 reports mentioned topiramate only. Eleven of the 19 patients were men. The median age of the 19 patients was 40 years (range, 3½– 82 years). Body temperatures ranged from 29·5 °C (moderate hypothermia) to 35 °C (mild hypothermia) with a median of 34 °C. Eleven of 18 reports of hypothermia occurred during the cooler months (one report did not indicate the time of year in which hyopthermia occurred). Comorbid conditions included hypothyroidism in six reports, five in patients who received valproic acid concomitantly with topiramate and five reports of hyperammonemia in similarly treated patients. Data mining scores (empirical Bayes geometric mean) for antiepileptic drugs ranged from a high of 5·845 for phenobarbital to 2·956 for gabapentin. Hypothermia was reported 4·7 times more frequently when topiramate was used than was statistically expected. Conclusion: We have found hypothermia, defined as an unintentional drop in body core temperature to <35 °C, to be associated with concomitant administration of topiramate (a carbonic anhydrase inhibitor) and valproic acid in patients who have tolerated either drug alone. Data mining analysis for topiramate showed a signal of hypothermia. Topiramate was reported 4·72 times more frequently in the database than would be statistically expected when considering all other drugs. Topiramate may act pharmacodynamically to potentiate the effects of valproic acid as a result of its ability to decrease blood HCO3− and increase blood ammonia levels. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOPIRAMATE
KW - ANTICONVULSANTS
KW - FRUCTOSE -- Derivatives
KW - CENTRAL nervous system depressants
KW - MUSCLE relaxants
KW - HYPOTHERMIA
KW - VALPROIC acid
KW - THERAPEUTIC use
KW - ammonia
KW - bicarbonate
KW - GABAA receptor
KW - hypothermia
KW - topiramate
KW - valproic acid
N1 - Accession Number: 34357257; Knudsen, J. F. 1,2; Email Address: james.knudsen@fda.hhs.gov Sokol, G. H. 3,4 Flowers, C. M. 5; Affiliation: 1: New Hope Cancer Center, Hudson, FL, USA 2: Division of Neurology and Psychiatry Drug Products, U.S. Food and Drug Administration, Silver Spring 3: H. Lee Moffitt Cancer Center at the University of South Florida College of Medicine, Tampa, FL, USA 4: Division of Oncology Drug Products, U.S. Food and Drug Administration, Silver Spring 5: Office of Drug Surveillance, U.S. Food and Drug Administration, Silver Spring, MD, USA; Source Info: Oct2008, Vol. 33 Issue 5, p513; Subject Term: TOPIRAMATE; Subject Term: ANTICONVULSANTS; Subject Term: FRUCTOSE -- Derivatives; Subject Term: CENTRAL nervous system depressants; Subject Term: MUSCLE relaxants; Subject Term: HYPOTHERMIA; Subject Term: VALPROIC acid; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: ammonia; Author-Supplied Keyword: bicarbonate; Author-Supplied Keyword: GABAA receptor; Author-Supplied Keyword: hypothermia; Author-Supplied Keyword: topiramate; Author-Supplied Keyword: valproic acid; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1365-2710.2008.00943.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34357257&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jin, S. K.
AU - Chung, H. J.
AU - Chung, M. W.
AU - Kim, J.-I.
AU - Kang, J.-H.
AU - Woo, S. W.
AU - Bang, S.
AU - Lee, S. H.
AU - Lee, H. J.
AU - Roh, J.
T1 - Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2008/10//
VL - 33
IS - 5
M3 - Article
SP - 567
EP - 573
PB - Wiley-Blackwell
SN - 02694727
AB - Background and objective: Genetic polymorphism of CYP2D6 leads to differences in pharmacokinetics of CYP2D6 substrates. The CYP2D6*10 allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the CYP2D6*10 allele in Korean subjects. Methods: One hundred and seven volunteers were recruited and grouped as CYP2D6*1/*1, CYP2D6*1/*10 and CYP2D6*10/*10 according to their genotypes. Metoprolol tartrate 100 mg (Betaloc®) was administered orally once to each subject in these three groups ( n = 6, 7 and 5, respectively). The pharmacokinetic parameters of metoprolol and its metabolite, α-hydroxymetoprolol, and the metabolic ratio for the three groups were estimated and compared. Results and discussion: The area under the plasma concentration–time curve (AUC0→∞), the maximum plasma concentration ( Cmax) and the elimination half-life ( T1/2) of metoprolol and α-hydroxymetoprolol for the CYP2D6*10/*10 group were all significantly different from those of the CYP2D6*1/*1 group ( P < 0·05). The AUC0→∞s of metoprolol were 443·7 ± 168·1, 995·6 ± 321·4 and 2545·3 ± 632·0 ng·h/mL, and the AUC0→∞s of α-hydroxymetoprolol were 1232·0 ± 311·2, 1344·0 ± 288·1 and 877·4 ± 103·4 ng·h/mL for groups CYP2D6*1/*1, *1/*10 and *10/*10, respectively. The corresponding T1/2 values of metoprolol were 2·7 ± 0·5, 3·2 ± 1·3 and 5·0 ± 1·1 h, while those of α-hydroxymetoprolol were 5·4±1·5, 6·0 ± 1·4 and 10·5 ± 4·2 h, respectively. The metabolic ratios of the three groups were significantly different ( P < 0·05). Conclusion: The CYP2D6*10 allele altered the pharmacokinetics of metoprolol in Korean subjects and is likely to affect other drugs metabolized by the CYP2D6 enzyme, similarly. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC polymorphisms
KW - PHARMACOKINETICS
KW - METOPROLOL
KW - ADRENERGIC beta blockers
KW - CARDIOVASCULAR agents
KW - PROPANOLAMINES
KW - CYP2D6
KW - Korean
KW - metoprolol
KW - pharmacokinetics
N1 - Accession Number: 34357255; Jin, S. K. 1; Email Address: rohjaesook@hanyang.ac.kr Chung, H. J. 1 Chung, M. W. 1 Kim, J.-I. 1 Kang, J.-H. 2 Woo, S. W. 1 Bang, S. 1 Lee, S. H. 3 Lee, H. J. 4 Roh, J. 5; Affiliation: 1: Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration 2: Department of Pharmacology, Medicinal Toxicology Research Center, College of Medicine, Center for Advanced Medical Education, Inha University, Incheon 3: Department of Thoracic & Cardiovascular Surgery, Korea University Anam Hospital 4: College of Pharmacy, Ewha Womans University, Seoul 5: Department of Obstetrics & Gynecology, Hanyang University Medical Center, Seoul, South Korea; Source Info: Oct2008, Vol. 33 Issue 5, p567; Subject Term: GENETIC polymorphisms; Subject Term: PHARMACOKINETICS; Subject Term: METOPROLOL; Subject Term: ADRENERGIC beta blockers; Subject Term: CARDIOVASCULAR agents; Subject Term: PROPANOLAMINES; Author-Supplied Keyword: CYP2D6; Author-Supplied Keyword: Korean; Author-Supplied Keyword: metoprolol; Author-Supplied Keyword: pharmacokinetics; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2710.2008.00945.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34357255&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105588325
T1 - Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
AU - Jin SK
AU - Chung HJ
AU - Chung MW
AU - Kim J
AU - Kang J
AU - Woo SW
AU - Bang S
AU - Lee SH
AU - Lee HJ
AU - Roh J
Y1 - 2008/10//
N1 - Accession Number: 105588325. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Supported by the Korea Food and Drug Administration. NLM UID: 8704308.
KW - Metoprolol -- Pharmacokinetics
KW - Oxidoreductases
KW - Polymorphism, Genetic
KW - Adult
KW - Alleles
KW - Female
KW - Funding Source
KW - Genotype
KW - Koreans
KW - Male
KW - Metoprolol -- Blood
KW - One-Way Analysis of Variance
KW - Post Hoc Analysis
KW - Human
SP - 567
EP - 573
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
JA - J CLIN PHARM THER
VL - 33
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background and objective: Genetic polymorphism of CYP2D6 leads to differences in pharmacokinetics of CYP2D6 substrates. The CYP2D6*10 allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the CYP2D6*10 allele in Korean subjects. Methods: One hundred and seven volunteers were recruited and grouped as CYP2D6*1/*1, CYP2D6*1/*10 and CYP2D6*10/*10 according to their genotypes. Metoprolol tartrate 100 mg (Betaloc(R)) was administered orally once to each subject in these three groups ( n = 6, 7 and 5, respectively). The pharmacokinetic parameters of metoprolol and its metabolite, [alpha]-hydroxymetoprolol, and the metabolic ratio for the three groups were estimated and compared. Results and discussion: The area under the plasma concentration-time curve (AUC0-->), the maximum plasma concentration ( Cmax) and the elimination half-life ( T1/2) of metoprolol and [alpha]-hydroxymetoprolol for the CYP2D6*10/*10 group were all significantly different from those of the CYP2D6*1/*1 group ( P < 0·05). The AUC0-->s of metoprolol were 443·7 ± 168·1, 995·6 ± 321·4 and 2545·3 ± 632·0 ng·h/mL, and the AUC0-->s of [alpha]-hydroxymetoprolol were 1232·0 ± 311·2, 1344·0 ± 288·1 and 877·4 ± 103·4 ng·h/mL for groups CYP2D6*1/*1, *1/*10 and *10/*10, respectively. The corresponding T1/2 values of metoprolol were 2·7 ± 0·5, 3·2 ± 1·3 and 5·0 ± 1·1 h, while those of [alpha]-hydroxymetoprolol were 5·4±1·5, 6·0 ± 1·4 and 10·5 ± 4·2 h, respectively. The metabolic ratios of the three groups were significantly different ( P < 0·05). Conclusion: The CYP2D6*10 allele altered the pharmacokinetics of metoprolol in Korean subjects and is likely to affect other drugs metabolized by the CYP2D6 enzyme, similarly.
SN - 0269-4727
AD - Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration
U2 - PMID: 18834373.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Maduri, A.
AU - Pearson, B.L.
AU - Wilson, S.E.
T1 - Lumbar–pelvic range and coordination during lifting tasks
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
Y1 - 2008/10//
VL - 18
IS - 5
M3 - Article
SP - 807
EP - 814
SN - 10506411
AB - Abstract: Spine motion has been described to have two regions, a neutral zone where lumbar rotation can occur with little resistance and an elastic zone where structures such as ligaments, facet joints and intervertebral disks resist rotation. In vivo, the passive musculature can contribute to further limiting the functional neutral range of lumbar motion. Movement out of this functional neutral range could potentially put greater loads on these structures. In this study, the range of lumbar curvature rotation was examined in twelve healthy, untrained volunteers at four torso inclination angles. The lumbar curvature during straight-leg lifting tasks was then defined as a percentage of this range of possible lumbar curvatures. Subjects were found to remain neutrally oriented during the flexion phase of a lifting task. During the extension phase of the lifting task, however, subjects were found to assume a more kyphotic posture, approaching the edge of the functional range of motion. This was found to be most pronounced for heavy lifting tasks. By allowing the lumbar curvature to go into a highly kyphotic posture, subjects may be taking advantage of stretch-shortening behavior in extensor musculature and associated tendons to reduce the energy required to raise the torso. Such a kyphotic posture during extension, however, may put excessive loading on the elastic structures of the spine and torso musculature increasing the risk of injury. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electromyography & Kinesiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUMBAR vertebrae
KW - MOTOR ability
KW - LIGAMENTS
KW - INTERVERTEBRAL disk
KW - MUSCLES
KW - TORSO
KW - CURVATURE
KW - Lifting
KW - Lumbar spine
KW - Manual materials handling
N1 - Accession Number: 34201379; Maduri, A. 1 Pearson, B.L. 2 Wilson, S.E. 3; Email Address: sewilson@ku.edu; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, United States 2: Burns and McDonnell, Kansas City, MO, United States 3: Human Motion Control Laboratory, Department of Mechanical Engineering, University of Kansas, 3138 Learned Hall, 1530 W. 15th Street, Lawrence, KS 66045, United States; Source Info: Oct2008, Vol. 18 Issue 5, p807; Subject Term: LUMBAR vertebrae; Subject Term: MOTOR ability; Subject Term: LIGAMENTS; Subject Term: INTERVERTEBRAL disk; Subject Term: MUSCLES; Subject Term: TORSO; Subject Term: CURVATURE; Author-Supplied Keyword: Lifting; Author-Supplied Keyword: Lumbar spine; Author-Supplied Keyword: Manual materials handling; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jelekin.2007.02.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105626619
T1 - Lumbar-pelvic range and coordination during lifting tasks.
AU - Maduri A
AU - Pearson BL
AU - Wilson SE
AU - Maduri, A
AU - Pearson, B L
AU - Wilson, S E
Y1 - 2008/10//
N1 - Accession Number: 105626619. Language: English. Entry Date: 20090130. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: P20 RR016475-01/RR/NCRR NIH HHS/United States. NLM UID: 9109125.
KW - Balance, Postural -- Physiology
KW - Lifting
KW - Lumbar Vertebrae -- Physiology
KW - Movement -- Physiology
KW - Pelvis -- Physiology
KW - Range of Motion -- Physiology
KW - Task Performance and Analysis
KW - Weight-Bearing -- Physiology
KW - Adult
KW - Female
KW - Male
KW - Human
SP - 807
EP - 814
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
JA - J ELECTROMYOGR KINESIOL
VL - 18
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - Spine motion has been described to have two regions, a neutral zone where lumbar rotation can occur with little resistance and an elastic zone where structures such as ligaments, facet joints and intervertebral disks resist rotation. In vivo, the passive musculature can contribute to further limiting the functional neutral range of lumbar motion. Movement out of this functional neutral range could potentially put greater loads on these structures. In this study, the range of lumbar curvature rotation was examined in twelve healthy, untrained volunteers at four torso inclination angles. The lumbar curvature during straight-leg lifting tasks was then defined as a percentage of this range of possible lumbar curvatures. Subjects were found to remain neutrally oriented during the flexion phase of a lifting task. During the extension phase of the lifting task, however, subjects were found to assume a more kyphotic posture, approaching the edge of the functional range of motion. This was found to be most pronounced for heavy lifting tasks. By allowing the lumbar curvature to go into a highly kyphotic posture, subjects may be taking advantage of stretch-shortening behavior in extensor musculature and associated tendons to reduce the energy required to raise the torso. Such a kyphotic posture during extension, however, may put excessive loading on the elastic structures of the spine and torso musculature increasing the risk of injury.
SN - 1050-6411
AD - National Institute for Occupational Safety and Health, Morgantown, WV, United States
AD - National Institute for Occupational Safety and Health, Morgantown, WV, United States.
U2 - PMID: 17449278.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lei Guo
AU - Qiang Shi
AU - Jia-Long Fang
AU - Nan Mei
AU - Ali, A. Afshan
AU - Lewis, Sherry M.
AU - Leakey, Julian E. A.
AU - Frankos, Vasilios H.
T1 - Review of Usnic Acid and Usnea Barbata Toxicity.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2008/10//Oct-Dec2008
VL - 26
IS - 4
M3 - Article
SP - 317
EP - 338
SN - 10590501
AB - Usnic acid is a prominent secondary lichen metabolite that has been used for various purposes worldwide. Crude extracts of usnic acid or pure usnic acid have been marketed in the United States as dietary supplements to aid in weight loss. The US Food and Drug Administration (FDA) received 21 reports of liver toxicity related to the ingestion of dietary supplements that contain usnic acid. This prompted the FDA to issue a warning about one such supplement, LipoKinetix, in 2001 (http://www.cfsan.fda.gov/~dms/ds-lipo.html). Subsequently, usnic acid and Usnea barbata lichen were nominated by the National Toxicology Program (NTP) for toxicity evaluations. At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acids
KW - Metabolites
KW - Dietary supplements
KW - Hepatotoxicology
KW - Weight loss
KW - Liver diseases
KW - United States
KW - usnic acid and Usnea barbata toxicity
KW - Weight loss dietary supplement
KW - United States. Food & Drug Administration
KW - National Toxicology Program (U.S.)
N1 - Accession Number: 35485049; Lei Guo 1; Email Address: lei.guo@fda.hhs.gov; Qiang Shi 1; Jia-Long Fang 1; Nan Mei 1; Ali, A. Afshan 1; Lewis, Sherry M. 1; Leakey, Julian E. A. 1; Frankos, Vasilios H. 2; Affiliations: 1: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.; 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA.; Issue Info: Oct-Dec2008, Vol. 26 Issue 4, p317; Thesaurus Term: Acids; Thesaurus Term: Metabolites; Thesaurus Term: Dietary supplements; Subject Term: Hepatotoxicology; Subject Term: Weight loss; Subject Term: Liver diseases; Subject: United States; Author-Supplied Keyword: usnic acid and Usnea barbata toxicity; Author-Supplied Keyword: Weight loss dietary supplement ; Company/Entity: United States. Food & Drug Administration ; Company/Entity: National Toxicology Program (U.S.); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; Number of Pages: 22p; Illustrations: 1 Black and White Photograph, 3 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1080/10590500802533392
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MEILI XI
AU - JIE ZHENG
AU - SHAOHUA ZHAO
AU - BROWN, ERIC W.
AU - JIANGHONG MENG
T1 - An Enhanced Discriminatory Pulsed-Field Gel Electrophoresis Scheme for Subtyping Salmonella Serotypes Heidelberg, Kentucky, SaintPaul, and Hadar.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/10//
VL - 71
IS - 10
M3 - Article
SP - 2067
EP - 2072
SN - 0362028X
AB - Conventional pulsed-field gel electrophoresis (PFGE) protocols, used extensively as a successful approach for subtyping many salmonellae, may be inadequate for discriminating strains sharing levels of homogeneity within the same serotype. Four additional restriction enzymes (SpeI, PacI, SfiI, and NotI), in addition to XbaI and BlnI, were used in PFGE typing of 33 Salmonella Heidelberg, 27 Salmonella Kentucky, 27 Salmonella SaintPaul, and 27 Salmonella Hadar isolates that were recovered from poultry and porcine retail meats from different states of the United States. A dendrogram derived from the combined analysis of six enzymes was highly discriminatory with a Simpson index of diversity value of over 0.950. The ratio of nodes to isolates was more than 0.75 with an average of fewer than three isolates in each polytomy for all four serotypes. Two three-enzyme combinations, SpeI/NotI/SfiI for Salmonella Heidelberg and Salmonella Hadar, and SpeI/BlnI/Sfil for Salmonella Kentucky and Salmonella SaintPaul, were found to have comparable discriminatory abilities of differentiating isolates of these Salmonella serotypes with the six-enzyme combination. The enhanced discriminatory PFGE-based subtyping scheme can be used effectively for the differentiation of strains of the four Salmonella serotypes. The findings also highlight PFGE analysis as a continued essential and informative subtyping method for source tracking and outbreak investigations of these and other Salmonella pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Meat
KW - Pulsed-field gel electrophoresis
KW - Enzymes
KW - United States
N1 - Accession Number: 35010614; MEILI XI 1; JIE ZHENG 2; SHAOHUA ZHAO 3; BROWN, ERIC W. 4; JIANGHONG MENG 1,2; Email Address: jmeng@umd.edu; Affiliations: 1: College of Food Science and Engineering, Northwest A&F University, Shaanxi, China; 2: Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742, USA; 3: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, Maryland 20708, USA; 4: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: Oct2008, Vol. 71 Issue 10, p2067; Thesaurus Term: Salmonella; Thesaurus Term: Meat; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Enzymes; Subject: United States; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; Number of Pages: 6p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jablonski, J. E.
AU - Jackson, L. S.
T1 - Stability of Picrotoxin during Yogurt Manufacture and Storage.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2008/10//
VL - 73
IS - 8
M3 - Article
SP - T121
EP - T128
SN - 00221147
AB - Picrotoxin is a neurotoxin found in the berries of Anamirta cocculus, a plant native to Southeast Asia. Picrotoxin has potential for being used as a biological weapon since the toxin is relatively easy to isolate and purify. Limited information exists on the stability and detection of picrotoxin added to foods before or after processing. The objective of this study was to determine the stability of picrotoxin during yogurt manufacture and storage. Direct, cup-set yogurt was produced by using methods that mimic the conditions used in full-scale production of yogurt. Milk (full-fat or low-fat) was pasteurized at 85 °C for 30 min, and then cooled to 43 °C. Yogurt starter culture (thermophilic culture or thermophilic + probiotic culture) and picrotoxin (200 μg/mL milk) were added. Samples of yogurt during fermentation (5 to 6 h, 43 °C) and during 30 d refrigerated (4 to 6 °C) storage were analyzed for pH, titratable acidity, and picrototoxin levels. Regardless of starter culture used or fat content of milk, there were no significant differences in the pH and titratable acidities of the picrotoxin-spiked yogurt and the control yogurt (no added picrotoxin) during fermentation and up to 4 wk of refrigerated storage. The color or texture of the yogurt was not affected by addition of picrotoxin. Levels of picrotoxinin and picrotin (components of picrotoxin) in yogurt, as measured by LC/MS (APCI+/SIR) did not change significantly during fermentation and storage. A separate experiment determined that addition of picrotoxin to milk before pasteurization (85 °C, 30 min) did not affect picrotoxin stability. These results indicate that picrotoxin is stable in yogurt during manufacture and storage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PICROTOXIN
KW - YOGURT
KW - FOOD -- Storage
KW - CULTURED milk
KW - DAIRY products
KW - LIQUID chromatography
KW - liquid chromatography-mass spectrometry (LC-MS)
KW - manufacture
KW - picrotoxin
KW - stability
KW - yogurt
N1 - Accession Number: 34643949; Jablonski, J. E. 1; Email Address: joseph.jablonski@fda.hhs.gov Jackson, L. S. 1; Affiliation: 1: U.S. Food and Drug Administration (FDA), Natl. Center for Food Safety & Technology (NCFST), 6502 S. Archer Rd., Summit-Argo, IL 60501, U.S.A.; Source Info: Oct2008, Vol. 73 Issue 8, pT121; Subject Term: PICROTOXIN; Subject Term: YOGURT; Subject Term: FOOD -- Storage; Subject Term: CULTURED milk; Subject Term: DAIRY products; Subject Term: LIQUID chromatography; Author-Supplied Keyword: liquid chromatography-mass spectrometry (LC-MS); Author-Supplied Keyword: manufacture; Author-Supplied Keyword: picrotoxin; Author-Supplied Keyword: stability; Author-Supplied Keyword: yogurt; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 445299 All Other Specialty Food Stores; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1750-3841.2008.00911.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Babu, Uma S.
AU - Gaines, Dennis M.
AU - Wu, Yang
AU - Westphal, Carmen D.
AU - Pereira, Marion
AU - Raybourne, Richard B.
T1 - Use of flow cytometry in an apoptosis assay to determine pH and temperature stability of shiga-like toxin 1
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2008/10//
VL - 75
IS - 2
M3 - Article
SP - 167
EP - 171
SN - 01677012
AB - Abstract: Shiga toxins and Shiga-like toxins (Stx) are a relatively large group of cytotoxins produced by certain serotypes of Shigella and E. coli (STEC). These toxins are responsible for diarrhea, hemorrhagic colitis and may induce hemolytic uremic syndrome (HUS) with serious consequences in young children. The toxins are proteins made up of 5 small B subunits responsible for binding to an outer membrane ligand on host cells and surround the larger, biologically active A subunit. For Shiga-like toxin 1 (Stx1), the cellular receptor is the carbohydrate globotriose. Stx1was purified from STEC. We utilized induction of apoptosis in the human monocyte cell line THP-1, as a biological endpoint to test the stability of Stx1 activity added to fruit punch at different pH (2–9) and temperatures (4 and 20 °C). A flow cytometric method was used to test for early and late apoptotic events based on binding of R-phycoerytherin-labeled annexin V to exposed membrane phosphatidyl serine. Membrane permeability to 7-Amino-actinomycin corresponds with late apoptosis or necrosis. The combination of acid pH and higher storage temperature resulted in greatest degree of toxin inactivation. This approach provides a rapid and high throughput method to determine the functional activity of Stx1, and related toxins in a food matrix. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLOW cytometry -- Diagnostic use
KW - APOPTOSIS
KW - BIOLOGICAL assay
KW - HYDROGEN-ion concentration
KW - TEMPERATURE
KW - VEROCYTOTOXINS
KW - ESCHERICHIA coli
KW - SHIGELLA
KW - Apoptosis
KW - Flow cytometry
KW - Shiga-like toxins
KW - THP-1 monocytes
N1 - Accession Number: 34199739; Babu, Uma S. 1 Gaines, Dennis M. 1 Wu, Yang 1 Westphal, Carmen D. 1 Pereira, Marion 1 Raybourne, Richard B.; Email Address: Richard.raybourne@fda.hhs.gov; Affiliation: 1: Immunobiology Branch, Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD, 20708 USA; Source Info: Oct2008, Vol. 75 Issue 2, p167; Subject Term: FLOW cytometry -- Diagnostic use; Subject Term: APOPTOSIS; Subject Term: BIOLOGICAL assay; Subject Term: HYDROGEN-ion concentration; Subject Term: TEMPERATURE; Subject Term: VEROCYTOTOXINS; Subject Term: ESCHERICHIA coli; Subject Term: SHIGELLA; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: Shiga-like toxins; Author-Supplied Keyword: THP-1 monocytes; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.mimet.2008.05.014
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhuang, Ziqing
AU - Groce, Dennis
AU - Ahlers, Heinz W.
AU - Iskander, Wafik
AU - Landsittel, Douglas
AU - Guffey, Steve
AU - Benson, Stacey
AU - Viscusi, Dennis
AU - Shaffer, Ronald E.
T1 - Correlation Between Respirator Fit and Respirator Fit Test Panel Cells by Respirator Size.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/10//
VL - 5
IS - 10
M3 - Article
SP - 617
EP - 628
PB - Taylor & Francis Ltd
SN - 15459624
AB - The National Institute for Occupational Safety and Health (NIOSH), recognizing the difficulties inherent in using old military data to define modern industrial respirator fit test panels, recently completed a study to develop an anthropometric database of the measurements of heads and faces of civilian respirator users. Based on the data collected, NIOSH researchers developed two new panels for fit testing half-facepiece and full-facepiece respirators. One of the new panels (NIOSH bivariate panel) uses face length and face width. The other panel is based on principal component analysis (PCA) to identify the linear combination of facial dimensions that best explains facial variations. The objective of this study was to investigate the correlation between respirator fit and the new NIOSH respirator fit test panel cells for various respirator sizes. This study was carried out on 30 subjects that were selected in part using the new NIOSH bivariate panel. Fit tests were conducted on the test subjects using a PORTACOUNT device and three exercises. Each subject was tested with three replications of four models of P-100 half-facepiece respirators in three sizes. This study found that respirator size significantly influenced fit within a given panel cell. Face size categories also matched the respirator sizing reasonably well, in that the small, medium, and large face size categories achieved the highest geometric mean fit factors in the small, medium, and large respirator sizes, respectively. The same pattern holds for fit test passing rate. Therefore, a correlation was found between respirator fit and the new NIOSH bivariate fit test panel cells for various respirator sizes. Face sizes classified by the PCA panel also followed a similar pattern with respirator fit although not quite as consistently. For the LANL panel, however, both small and medium faces achieved best fit in small size respirators, and large faces achieved best fit in medium respirators. These findings support the selection of the facial dimensions for developing the new NIOSH bivariate respirator fit test panel. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Respirators (Medical equipment)
KW - Databases
KW - Medical equipment -- Design & construction
KW - Anthropometry
KW - Testing -- Equipment & supplies
KW - Testing equipment industry
KW - Breathing apparatus
KW - fit test panels
KW - fit testing
KW - respirator size
KW - respirators
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 33718601; Zhuang, Ziqing 1; Groce, Dennis 2,3; Ahlers, Heinz W. 1; Iskander, Wafik 3; Landsittel, Douglas 1,4; Guffey, Steve 3; Benson, Stacey 2; Viscusi, Dennis 1; Shaffer, Ronald E. 1; Affiliations: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania, USA; 2: EG&G Technical Services Inc., Pittsburgh, Pennsylvania, USA; 3: Department of Industrial and Management Systems Engineering, West Virginia University, Morgantown, West Virginia, USA; 4: Duquesne University, Department of Mathematics and Computer Science, Pittsburgh, Pennsylvania, USA; Issue Info: Oct2008, Vol. 5 Issue 10, p617; Thesaurus Term: Industrial safety; Subject Term: Respirators (Medical equipment); Subject Term: Databases; Subject Term: Medical equipment -- Design & construction; Subject Term: Anthropometry; Subject Term: Testing -- Equipment & supplies; Subject Term: Testing equipment industry; Subject Term: Breathing apparatus; Author-Supplied Keyword: fit test panels; Author-Supplied Keyword: fit testing; Author-Supplied Keyword: respirator size; Author-Supplied Keyword: respirators ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 12p; Illustrations: 1 Diagram, 9 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/15459620802293810
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kowalski-Trakofler, Kathleen M.
AU - Vaught, Charles
AU - Brnich Jr., Michael J.
T1 - Expectations Training for Miners Using Self-Contained Self-Rescuers in Escapes from Underground Coal Mines.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/10//
VL - 5
IS - 10
M3 - Article
SP - 671
EP - 677
PB - Taylor & Francis Ltd
SN - 15459624
AB - National Institute for Occupational Safety and Health researchers conducted a study to investigate the human response issues related to wearing a self-contained self-rescuer (SCSR). The goal was to develop training to educate miners on what they could expect from their units during an escape. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Results identified nine key areas of concern: (1) starting the unit, (2) unit heat, (3) induction of coughing, (4) unit taste, (5) difficulty in breathing while wearing the unit, (6) quality of the air supplied, (7) nose clips, (8) goggles, and (9) the behavior of the breathing bag. In addition, researchers reviewed the literature on human response under duress. This article describes the expectations training program, which comprises the findings of the SCSR study and what is known about the normal human response in an emergency. The authors present background on SCSRs and the SCSR switchover procedure mandated in the recent federal Mine Improvement and New Emergency Response Act of 2006, which provided the impetus for the expectations training. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Emergency management
KW - Industrial safety
KW - Industrial research
KW - Miners -- Training of
KW - Self-contained self-rescuer (Mine rescue equipment)
KW - Mine rescue work
KW - Occupational training
KW - United States
KW - disaster
KW - escape
KW - mining
KW - self-contained self-rescuer
KW - training
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 33718595; Kowalski-Trakofler, Kathleen M. 1; Email Address: kkowalski@cdc.gov; Vaught, Charles 1; Brnich Jr., Michael J. 1; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA; Issue Info: Oct2008, Vol. 5 Issue 10, p671; Thesaurus Term: Emergency management; Thesaurus Term: Industrial safety; Subject Term: Industrial research; Subject Term: Miners -- Training of; Subject Term: Self-contained self-rescuer (Mine rescue equipment); Subject Term: Mine rescue work; Subject Term: Occupational training; Subject: United States; Author-Supplied Keyword: disaster; Author-Supplied Keyword: escape; Author-Supplied Keyword: mining; Author-Supplied Keyword: self-contained self-rescuer; Author-Supplied Keyword: training ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 624310 Vocational Rehabilitation Services; Number of Pages: 7p; Illustrations: 1 Color Photograph; Document Type: Article
L3 - 10.1080/15459620802333632
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=33718595&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105809960
T1 - Correlation between respirator fit and respirator fit test panel cells by respirator size.
AU - Zhuang Z
AU - Groce D
AU - Ahlers HW
AU - Iskander W
AU - Landsittel D
AU - Guffey S
AU - Benson S
AU - Viscusi D
AU - Shaffer RE
Y1 - 2008/10//
N1 - Accession Number: 105809960. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Cephalometry
KW - Face -- Anatomy and Histology
KW - Respiratory Protective Devices -- Standards
KW - Environmental Exposure -- Prevention and Control
KW - Equipment Design
KW - Female
KW - Male
KW - National Institute for Occupational Safety and Health
KW - Occupational Exposure -- Prevention and Control
KW - United States
KW - Human
SP - 617
EP - 628
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The National Institute for Occupational Safety and Health (NIOSH), recognizing the difficulties inherent in using old military data to define modern industrial respirator fit test panels, recently completed a study to develop an anthropometric database of the measurements of heads and faces of civilian respirator users. Based on the data collected, NIOSH researchers developed two new panels for fit testing half-facepiece and full-facepiece respirators. One of the new panels (NIOSH bivariate panel) uses face length and face width. The other panel is based on principal component analysis (PCA) to identify the linear combination of facial dimensions that best explains facial variations. The objective of this study was to investigate the correlation between respirator fit and the new NIOSH respirator fit test panel cells for various respirator sizes. This study was carried out on 30 subjects that were selected in part using the new NIOSH bivariate panel. Fit tests were conducted on the test subjects using a PORTACOUNT device and three exercises. Each subject was tested with three replications of four models of P-100 half-facepiece respirators in three sizes. This study found that respirator size significantly influenced fit within a given panel cell. Face size categories also matched the respirator sizing reasonably well, in that the small, medium, and large face size categories achieved the highest geometric mean fit factors in the small, medium, and large respirator sizes, respectively. The same pattern holds for fit test passing rate. Therefore, a correlation was found between respirator fit and the new NIOSH bivariate fit test panel cells for various respirator sizes. Face sizes classified by the PCA panel also followed a similar pattern with respirator fit although not quite as consistently. For the LANL panel, however, both small and medium faces achieved best fit in small size respirators, and large faces achieved best fit in medium respirators. These findings support the selection of the facial dimensions for developing the new NIOSH bivariate respirator fit test panel.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania 15236, USA. zaz3cdc.gov
U2 - PMID: 18666022.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105809960&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105809964
T1 - Expectations training for miners using self-contained self-rescuers in escapes from underground coal mines.
AU - Kowalski-Trakofler KM
AU - Vaught C
AU - Brnich MJ Jr
Y1 - 2008/10//
N1 - Accession Number: 105809964. Language: English. Entry Date: 20080905. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Mining -- Education
KW - Occupational Health
KW - Respiratory Protective Devices
KW - Equipment Design
KW - National Institute for Occupational Safety and Health
KW - Oxygen -- Administration and Dosage
KW - United States
SP - 671
EP - 677
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - National Institute for Occupational Safety and Health researchers conducted a study to investigate the human response issues related to wearing a self-contained self-rescuer (SCSR). The goal was to develop training to educate miners on what they could expect from their units during an escape. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Results identified nine key areas of concern: (1) starting the unit, (2) unit heat, (3) induction of coughing, (4) unit taste, (5) difficulty in breathing while wearing the unit, (6) quality of the air supplied, (7) nose clips, (8) goggles, and (9) the behavior of the breathing bag. In addition, researchers reviewed the literature on human response under duress. This article describes the expectations training program, which comprises the findings of the SCSR study and what is known about the normal human response in an emergency. The authors present background on SCSRs and the SCSR switchover procedure mandated in the recent federal Mine Improvement and New Emergency Response Act of 2006, which provided the impetus for the expectations training.
SN - 1545-9624
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania 15236-0070, USA. kkowalski@cdc.gov
U2 - PMID: 18671153.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105809964&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Garcia, Roberta J.
AU - Kane, Andrew S.
AU - Petullo, David
AU - Reimschuessel, Renate
T1 - LOCALIZATION OF OXYTETRACYCLINE IN CHLAMYDOMONAS REINHARDTII (CHLOROPHYCEAE).
JO - Journal of Phycology
JF - Journal of Phycology
Y1 - 2008/10//
VL - 44
IS - 5
M3 - Article
SP - 1282
EP - 1289
PB - Wiley-Blackwell
SN - 00223646
AB - Oxytetracycline (OTC) is an important antimicrobial used in aquaculture. However, residues of OTC have been isolated from nontarget aquatic organisms, sediments, and water located near aquaculture facilities. Identifying OTC in plant material is particularly difficult due to interference from pigments and polyphenol substances but is important especially for algae since they are a primary food source for fish in early life stages. In this study, we describe the effect of OTC (0.1, 1, 10, 25, 50, 100 μg · mL−1) on cell growth, and the localization of OTC (0, 1, 25, 100 μg · mL−1) in vacuoles of Chlamydomonas reinhardtii P. A. Dang. (wildtype, ATCC 18798). We also present a method for semiquantifying OTC in living cells using fluorescent microscopy and Adobe Photoshop. We exposed algal cells to OTC and sampled after 2 or 7 d exposure. On day 7, OTC significantly inhibited algal growth at 1, 10, 25, 50, and 100 μg · mL−1. When viewed with fluorescent microscopy, cells exposed to the 25 and 100 μg · mL−1 contained yellow fluorescent areas, ≤1 μm in diameter that were easily discernable against the red fluorescence of the intracellular chl. The fluorescent areas corresponded to small spherical vacuoles (i.e., polyphosphate bodies that contain calcium and magnesium complexed with polyphosphate) seen in the cells by LM. Since OTC has a high affinity for divalent cations, we suggest that OTC is localized in these vacuoles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Phycology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aquatic organisms
KW - Green algae
KW - RESEARCH
KW - Chlamydomonas reinhardtii
KW - Chlamydomonadaceae
KW - Oxytetracycline
KW - Tetracyclines
KW - Plant vacuoles
KW - Algae
KW - oxytetracycline
KW - vacuoles
N1 - Accession Number: 34643648; Garcia, Roberta J. 1,2; Kane, Andrew S. 3; Petullo, David 4; Reimschuessel, Renate 4; Email Address: renate.reimschuessel@fda.hhs.gov; Affiliations: 1: Marine Estuarine Environmental Sciences Program, University of Maryland Baltimore, Baltimore, Maryland 21201, USA Aquatic Pathobiology Center, VA-MD Regional College of Veterinary Medicine, Maryland Campus, 8075 Greenmead Drive, College Park, Maryland 20742, USA; 2: Aquatic Pathobiology Center, VA-MD Regional College of Veterinary Medicine, Maryland Campus, 8075 Greenmead Drive, College Park, Maryland 20742, USA; 3: Emerging Pathogens Institute, PO Box 100009, University of Florida, Gainesville, Florida 32610-0009, USA; 4: Center for Veterinary Medicine, FDA, 7500 Standish Place, Rockville, Maryland 20855, USA; Issue Info: Oct2008, Vol. 44 Issue 5, p1282; Thesaurus Term: Aquatic organisms; Thesaurus Term: Green algae; Thesaurus Term: RESEARCH; Subject Term: Chlamydomonas reinhardtii; Subject Term: Chlamydomonadaceae; Subject Term: Oxytetracycline; Subject Term: Tetracyclines; Subject Term: Plant vacuoles; Subject Term: Algae; Author-Supplied Keyword: oxytetracycline; Author-Supplied Keyword: vacuoles; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 8p; Illustrations: 2 Diagrams, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1529-8817.2008.00574.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34643648&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Talk to Your Clients about Quitting Smoking
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2008/10//
VL - 108
IS - 10
M3 - Editorial
SP - 1600
EP - 1600
SN - 00028223
N1 - Accession Number: 34580979; Galson, Steven K. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Oct2008, Vol. 108 Issue 10, p1600; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2008.08.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34580979&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105709920
T1 - Talk to your clients about quitting smoking.
AU - Galson SK
Y1 - 2008/10//
N1 - Accession Number: 105709920. Language: English. Entry Date: 20081212. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 7503061.
KW - Practice Guidelines
KW - Smoking Cessation
KW - Dietitians
KW - Health Promotion
KW - Information Resources
KW - Smoking -- Complications
SP - 1600
EP - 1600
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 108
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Department of Health and Human Services.
U2 - PMID: 18926116.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105709920&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105709463
T1 - Trends in racial disparities among the elderly for selected procedures.
AU - Basu J
AU - Mobley LR
Y1 - 2008/10//
N1 - Accession Number: 105709463. Language: English. Entry Date: 20081205. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Agency for Healthcare Research and Quality (AHRQ) and RTI International. NLM UID: 9506850.
KW - Health Services Accessibility -- Trends
KW - Population
KW - Surgery, Operative
KW - Aged
KW - Aged, 80 and Over
KW - Databases
KW - Female
KW - Funding Source
KW - Male
KW - Referral and Consultation
KW - United States
KW - Human
SP - 617
EP - 637
JO - Medical Care Research & Review
JF - Medical Care Research & Review
JA - MED CARE RES REV
VL - 65
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - The authors examine trends over 1997-2001 in racial or ethnic disparities in the utilization of three costly, referral-sensitive procedures among the elderly-coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), and hip/joint replacement. Using a multivariate framework, they undertake a simultaneous examination of the relationships between patient, local area context, and health systems on these admission types after comparing them to a control group. This period spans the implementation of the Balanced Budget Act and a major Department of Health and Human Services initiative to reduce disparities in cardiovascular and other diseases. Findings suggest increasing disparities for African Americans relative to Whites in their lower utilization of CABG and PTCA over time, and increasing disparities in the utilization of hip/joint replacement among other races' relative to Whites. The authors find that racial or ethnic disparities in use of referral-sensitive procedures did not narrow over 1997-2001.
SN - 1077-5587
AD - Agency for Healthcare Research and Quality, Rockville, Maryland
U2 - PMID: 18490701.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105709463&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kyprianou, Iacovos S.
AU - Badano, Aldo
AU - Gallas, Brandon D.
AU - Myers, Kyle J.
T1 - Singular value description of a digital radiographic detector: Theory and measurements.
JO - Medical Physics
JF - Medical Physics
Y1 - 2008/10//
VL - 35
IS - 10
M3 - Article
SP - 4744
EP - 4756
SN - 00942405
AB - The H operator represents the deterministic performance of any imaging system. For a linear, digital imaging system, this system operator can be written in terms of a matrix, H, that describes the deterministic response of the system to a set of point objects. A singular value decomposition of this matrix results in a set of orthogonal functions (singular vectors) that form the system basis. A linear combination of these vectors completely describes the transfer of objects through the linear system, where the respective singular values associated with each singular vector describe the magnitude with which that contribution to the object is transferred through the system. This paper is focused on the measurement, analysis, and interpretation of the H matrix for digital x-ray detectors. A key ingredient in the measurement of the H matrix is the detector response to a single x ray (or infinitestimal x-ray beam). The authors have developed a method to estimate the 2D detector shift-variant, asymmetric ray response function (RRF) from multiple measured line response functions (LRFs) using a modified edge technique. The RRF measurements cover a range of x-ray incident angles from 0° (equivalent location at the detector center) to 30° (equivalent location at the detector edge) for a standard radiographic or cone-beam CT geometric setup. To demonstrate the method, three beam qualities were tested using the inherent, Lu/Er, and Yb beam filtration. The authors show that measures using the LRF, derived from an edge measurement, underestimate the system’s performance when compared with the H matrix derived using the RRF. Furthermore, the authors show that edge measurements must be performed at multiple directions in order to capture rotational asymmetries of the RRF. The authors interpret the results of the H matrix SVD and provide correlations with the familiar MTF methodology. Discussion is made about the benefits of the H matrix technique with regards to signal detection theory, and the characterization of shift-variant imaging systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGING systems
KW - RADIOGRAPHY
KW - X-rays
KW - DETECTORS
KW - TRANSFER functions (Mathematics)
KW - edge method
KW - H matrix
KW - line spread function
KW - MTF
KW - system response
N1 - Accession Number: 34621911; Kyprianou, Iacovos S. 1; Email Address: iacovos.kyprianou@fda.hhs.gov Badano, Aldo 1 Gallas, Brandon D. 1 Myers, Kyle J. 1; Affiliation: 1: NIBIB/CDRH Laboratory for the Assessment of Medical Imaging Systems, US Food and Drug Administration, New Hampshire Avenue, Silver Spring, Maryland 20993; Source Info: Oct2008, Vol. 35 Issue 10, p4744; Subject Term: IMAGING systems; Subject Term: RADIOGRAPHY; Subject Term: X-rays; Subject Term: DETECTORS; Subject Term: TRANSFER functions (Mathematics); Author-Supplied Keyword: edge method; Author-Supplied Keyword: H matrix; Author-Supplied Keyword: line spread function; Author-Supplied Keyword: MTF; Author-Supplied Keyword: system response; NAICS/Industry Codes: 333316 Photographic and Photocopying Equipment Manufacturing; NAICS/Industry Codes: 334118 Computer Terminal and Other Computer Peripheral Equipment Manufacturing; Number of Pages: 13p; Illustrations: 1 Black and White Photograph, 1 Diagram, 6 Graphs; Document Type: Article
L3 - 10.1118/1.2975222
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34621911&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Minjeong Lee
AU - Yongkeun Son
AU - Jongseo Park
AU - Youngkwan Lee
T1 - Enhanced Sensitivity of a Glucose Sensor Adopting Polymer Microtubule.
JO - Molecular Crystals & Liquid Crystals
JF - Molecular Crystals & Liquid Crystals
Y1 - 2008/10//
VL - 492
IS - 1
M3 - Article
SP - 155
EP - 164
SN - 15421406
AB - Sensitivity of a glucose biosensor based on conducting polymer micro-tubule was enhanced by introducing a Pt transducer layer. Electrochemical template synthesis using polycarbonate membrane was used to fabricate the micro tubule. Glucose oxidase from Aspergillus Niger was caged into the micro tubule structure by capping the mouth of the tubule with a nano porous polycarbonate membrane. This capped tubule structure worked as a cell-array retaining enzyme inside and as a sensing current collector for the electrochemical reaction of the species retained inside simultaneously. The nano pores of the capping membrane were filled with poly (1,3-phenylenediamine) by using electrochemical polymerization. Introducing a Pt transducer layer at the bottom side of the template enhanced the sensitivity of the sensor about sixty times compared to the one having Au layer. The larger the pore size of the template was, the faster was the response and the higher was the detection current because of the faster material transport into and out of the cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Crystals & Liquid Crystals is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - GLUCOSE
KW - MICROTUBULES
KW - DETECTORS
KW - POLYMERS
KW - TRANSDUCERS
KW - capping film
KW - electropolymerization
KW - glucose biosensor
KW - microtubules
KW - Pt transducer layer
N1 - Accession Number: 34783543; Minjeong Lee 1 Yongkeun Son 1; Email Address: ykson@skku.edu Jongseo Park 2 Youngkwan Lee 3; Affiliation: 1: Department of Chemistry, and Advanced Materials and Process Research Center for IT, Sungkyunkwan University, Suwon, Korea 2: Korea Food and Drug Administration, Seoul, Korea 3: Department of Chemical Engineering, Sungkyunkwan University, Suwon, Korea; Source Info: 2008, Vol. 492 Issue 1, p155; Subject Term: BIOSENSORS; Subject Term: GLUCOSE; Subject Term: MICROTUBULES; Subject Term: DETECTORS; Subject Term: POLYMERS; Subject Term: TRANSDUCERS; Author-Supplied Keyword: capping film; Author-Supplied Keyword: electropolymerization; Author-Supplied Keyword: glucose biosensor; Author-Supplied Keyword: microtubules; Author-Supplied Keyword: Pt transducer layer; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; Number of Pages: 10p; Illustrations: 2 Black and White Photographs, 4 Graphs; Document Type: Article
L3 - 10.1080/15421400802332925
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34783543&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Shaw T
AU - Dou, Jinhui
AU - Temple, Robert
AU - Agarwal, Rajiv
AU - Wu, Kuei-Meng
AU - Walker, Susan
T1 - New therapies from old medicines.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2008/10//
VL - 26
IS - 10
M3 - Article
SP - 1077
EP - 1083
SN - 10870156
AB - The article discusses the development of botanical prescription drugs that meet the standards set forth by the U.S. Food and Drug Administration (FDA) for clinical testing and quality control. In October 2006 the FDA approved the new drug application (NDA) for sinecatechins, a topical treatment for perianal and genital condyloma derived from green tea leaves. This approval proves that natural therapies can be developed to meet the guidelines set forth for botanical drug products in 2004. Due to botanical products being derived from raw materials that are minimally purified, contamination with pesticides, trace heavy metals and infectious microorganisms is of concern. Steps to ensuring approval are given.
KW - Medical botany
KW - Raw materials
KW - Drug laws & regulations -- United States
KW - Pharmaceutical research
KW - Drug approval
KW - Genital warts -- Treatment
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 34681331; Chen, Shaw T 1; Dou, Jinhui 1; Temple, Robert 1; Agarwal, Rajiv 1; Wu, Kuei-Meng 1; Walker, Susan 1; Affiliations: 1: Shaw T. Chen is associate director & botanical team leader, Jinhui Dou is pharmacognosy reviewer, Robert Temple is director of the Office of Drug Evaluation, Rajiv Agarwal is chemistry reviewer, Kuei-Meng Wu is pharmacology reviewer and Susan Walker is director of the Division of Dermatological and Dental Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Silver Spring, Maryland 20993-0002, USA. shaw.chen@fda.hhs.gov; Issue Info: Oct2008, Vol. 26 Issue 10, p1077; Thesaurus Term: Medical botany; Thesaurus Term: Raw materials; Subject Term: Drug laws & regulations -- United States; Subject Term: Pharmaceutical research; Subject Term: Drug approval; Subject Term: Genital warts -- Treatment; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; Number of Pages: 7p; Illustrations: 1 Color Photograph, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1038/nbt1008-1077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34681331&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105574558
T1 - Peer and role model influences for cigarette smoking in a young adult military population.
AU - Green KJ
AU - Hunter CM
AU - Bray RM
AU - Pemberton M
AU - Williams J
AU - Green, Kathy J
AU - Hunter, Christine M
AU - Bray, Robert M
AU - Pemberton, Michael
AU - Williams, Jason
Y1 - 2008/10//
N1 - Accession Number: 105574558. Language: English. Entry Date: 20090130. Revision Date: 20161119. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; UK & Ireland. Grant Information: Z99 DK999999//Intramural NIH HHS/United States. NLM UID: 9815751.
KW - Behavior, Addictive -- Epidemiology
KW - Interpersonal Relations
KW - Military Personnel -- Statistics and Numerical Data
KW - Peer Group
KW - Smoking -- Epidemiology
KW - Adult
KW - Behavior, Addictive -- Psychosocial Factors
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Female
KW - Male
KW - Military Personnel -- Psychosocial Factors
KW - Odds Ratio
KW - Questionnaires
KW - Risk Taking Behavior
KW - Smoking Cessation
KW - Smoking -- Psychosocial Factors
KW - Social Environment
KW - United States
KW - Human
SP - 1533
EP - 1541
JO - Nicotine & Tobacco Research
JF - Nicotine & Tobacco Research
JA - NICOTINE TOBACCO RES
VL - 10
IS - 10
PB - Oxford University Press / USA
AB - Previous research has shown that 8% to 10% of nonsmokers initiated smoking during their first year of military service despite a period of forced abstinence during boot camp. To our knowledge, no studies have looked at the influence of peers and role models on the initiation of smoking among U.S. Air Force personnel who recently completed boot camp. This cross-sectional study examined the role of perceived peer norms, roommate influence, role model influence, perceived norms of all active duty personnel, and depressive symptoms in the initiation and reinitiation of smoking among 2,962 Air Force technical training students. Previous nonsmokers were more likely to initiate smoking if they perceived that the majority of their classmates smoked (OR = 1.67, 95% CI[1.05-2.67]) and if they reported that their military training leader or classroom instructor used tobacco products (OR = 1.69, 95% CI[1.12-2.56]). Additionally, previous nonsmokers were more likely to initiate smoking if their roommate smoked (OR = 1.67, 95% CI[1.09-2.56]). Similar results were seen with previous smokers who perceived that the majority of their classmates smoked (OR = 1.63, 95% CI[1.03-2.58]) and if they reported that their military training leader or classroom instructor used tobacco products (OR = 1.95, 95% CI[1.29-2.94]). Our study suggests that military role models who use tobacco, peer smoking behavior, and perceived smoking norms increase the likelihood of smoking initiation among newly enlisted military personnel who have recently undergone a period of forced abstinence.
SN - 1462-2203
AD - United States Air Force, Health Promotion, Air Force Medical Operations Agency, Office of the Surgeon General, Bolling AFB, DC 20032-7050, USA
AD - United States Air Force, Health Promotion, Air Force Medical Operations Agency, Office of the Surgeon General, Bolling AFB, DC 20032-7050, USA. kathy.green@pentagon.af.mil
U2 - PMID: 18946772.
DO - 10.1080/14622200802398763
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105574558&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Woo, Eileen
T1 - Speak up about patient allergies.
JO - Nursing
JF - Nursing
Y1 - 2008/10//
VL - 38
IS - 10
M3 - Article
SP - 13
EP - 13
SN - 03604039
AB - The article offers guidelines for nurses on handling patients with allergic reactions to synthetic absorbable sterile surgical suture. A case is presented involving a patient with a history of an allergic reaction to synthetic absorbable sterile surgical suture. It recommends that nurses pay special attention to the patient's history of allergies.
KW - ALLERGY
KW - SUTURES
KW - NURSE & patient
KW - NURSING
KW - NURSES
N1 - Accession Number: 35823184; Woo, Eileen 1; Affiliation: 1: Center for Devices and Radiological Health; Source Info: Oct2008, Vol. 38 Issue 10, p13; Subject Term: ALLERGY; Subject Term: SUTURES; Subject Term: NURSE & patient; Subject Term: NURSING; Subject Term: NURSES; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; Number of Pages: 2/3p; Illustrations: 1 Color Photograph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105682505
T1 - Device safety. Speak up about patient allergies.
AU - Woo E
Y1 - 2008/10//
N1 - Accession Number: 105682505. Language: English. Entry Date: 20081107. Revision Date: 20150711. Publication Type: Journal Article; brief item; pictorial; questions and answers. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 7600137.
KW - Hypersensitivity
KW - Patient Identification
KW - Patient Safety
KW - Sutures
KW - Patient Advocacy
SP - 13
EP - 13
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health.
U2 - PMID: 18812983.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105682505&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic.
AU - Youfa Wang
AU - Beydoun, May A.
AU - Lan Liang
AU - Caballero, Benjamin
AU - Kumanyika, Shiriki K.
JO - Obesity (19307381)
JF - Obesity (19307381)
Y1 - 2008/10//
VL - 16
IS - 10
SP - 2323
EP - 2330
SN - 19307381
N1 - Accession Number: 36872105; Author: Youfa Wang: 1 email: ywang@jhsph.edu. Author: Beydoun, May A.: 1 Author: Lan Liang: 2 Author: Caballero, Benjamin: 1 Author: Kumanyika, Shiriki K.: 3 ; Author Affiliation: 1 Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA: 2 Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland, USA: 3 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20150711
N2 - The article focuses on a study which predicted the potential problem of obesity prevalence and health-care costs of obesity in the U.S. It analyzes the data collected between 1970s and 2004. Obesity trends in children, women and men are described. Projections through 2030 are given. Researchers suggest that effective development and implementation of corrective programs or policies are needed to prevent the predicted health and societal consequences of the obesity epidemic.
KW - *METABOLIC disorders
KW - *OBESITY
KW - *EPIDEMICS
KW - *MEDICAL care
KW - *BODY weight
KW - RESEARCH
KW - UNITED States
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=36872105&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
ID - 105572603
T1 - Fda drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2.
AU - Ryan Q
AU - Ibrahim A
AU - Cohen MH
AU - Johnson J
AU - Ko C
AU - Sridhara R
AU - Justice R
AU - Pazdur R
Y1 - 2008/10//
N1 - Accession Number: 105572603. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Breast Neoplasms -- Drug Therapy
KW - Drug Approval
KW - Neoplasm Metastasis -- Drug Therapy
KW - Drug Resistance, Neoplasm
KW - Education, Continuing (Credit)
KW - HER-2-neu Oncogene
KW - Phosphotransferases -- Antagonists and Inhibitors
KW - Treatment Outcomes
KW - United States Food and Drug Administration
SP - 1114
EP - 1119
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 10
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On March 13, 2007, the U.S. Food and Drug Administration approved lapatinib (Tykerb® tablets; GlaxoSmithKline, Philadelphia), an oral, small molecule, dual tyrosine kinase inhibitor of ErbB-2 and ErbB-1, for use in combination with capecitabine for the treatment of patients with human epidermal growth factor receptor (HER)-2DSoverexpressing metastatic breast cancer who had received prior therapy including an anthracycline, a taxane, and trastuzumab.One multicenter, open-label, randomized trial was submitted. Eligible patients had stage IIIb or IV breast cancer, ErbB-2 overexpression (immunohistochemistry 3+ or 2+ with fluorescence in situ hybridization confirmation), measurable disease, a 0 or 1 Eastern Cooperative Oncology Group performance status score, a cardiac ejection fraction within the institutional normal range, and adequate laboratory function.Patients received either lapatinib (1,250 mg once daily on days 1DS21) plus capecitabine (1,000 mg/m2 every 12 hours on days 1DS14) every 21 days or capecitabine alone (1,250 mg/m2 every 12 hours on days 1DS14) every 21 days.The primary endpoint was time to progression (TTP) determined by a blinded independent review panel. After TTP results of a prespecified interim analysis were made available, study enrollment was discontinued (399 patients enrolled).The median TTP was 27.1 versus 18.6 weeks (hazard ratio, 0.57; p = .00013) favoring the lapatinib plus capecitabine arm. Response rates were 23.7% (lapatinib plus capecitabine) versus 13.9% (capecitabine alone). Survival data were not mature.Although the toxicities observed in the lapatinib and capecitabine combination arm were generally similar to those in the capecitabine alone arm, a higher incidence of diarrhea and rash was noted with the combination. Grade 3 or 4 adverse reactions that occurred with a frequency of >5% in patients on the combination arm were diarrhea (13%) and palmarDSplantar erythrodysesthesia (12%). There was a 2% incidence of reversible decreased left ventricular function in the combination arm.
SN - 1083-7159
AD - Division of Drug Oncology Products, Office of Oncology Drug Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
U2 - PMID: 18849320.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105572603&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105572605
T1 - Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy.
AU - Hazarika M
AU - Rock E
AU - Williams G
AU - Dagher R
AU - Sridhara R
AU - Booth B
AU - Farrell A
AU - Justice R
AU - Pazdur R
Y1 - 2008/10//
N1 - Accession Number: 105572605. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents, Combined -- Therapeutic Use
KW - Multiple Myeloma -- Drug Therapy
KW - Thalidomide -- Antagonists and Inhibitors
KW - Clinical Trials
KW - Dexamethasone -- Therapeutic Use
KW - Kaplan-Meier Estimator
KW - Log-Rank Test
KW - Treatment Outcomes
KW - Human
SP - 1120
EP - 1127
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 10
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Purpose. Lenalidomide (CC-5013, Revlimid®; Celgene Corporation, Summit, NJ), a thalidomide analogue, was granted approval by the U.S. Food and Drug Administration (FDA) on June 29, 2006, for use in combination with dexamethasone in patients with multiple myeloma (MM) who have received at least one prior therapy. The FDA approved lenalidomide with a restricted distribution program, RevAssist®.Experimental Design. In two randomized, double-blind, multicenter studies, the combination of lenalidomide and dexamethasone (LD) was compared with placebo and dexamethasone (PD) in patients with MM who had received at least one prior therapy. The primary endpoint was time to progression (TTP).Results. Following a prespecified interim analysis of TTP, an independent data-monitoring committee advised the sponsor to halt the two studies. For both studies, the interim analysis for efficacy revealed a statistically significant longer TTP with LD than with PD.The most clinically relevant grade 3 and 4 adverse events that occurred more frequently in the LD arm were neutropenia, thrombocytopenia, deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Thrombotic or thromboembolic events, including deep vein thrombosis, pulmonary embolism, thrombosis, and intracranial venous sinus thrombosis were reported more frequently in patients treated with LD than with PD.Conclusions. The FDA approved lenalidomide based on interim results from two multicenter, placebo-controlled, randomized trials comparing the combination of LD with PD that revealed a longer TTP with LD than with PD. The major toxicity observed during these trials was myelosuppression. The serious toxicities included thromboembolic events. Lenalidomide is only available under the RevAssist® Program.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA
U2 - PMID: 18922829.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105572605&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - He, Qinghang
AU - Zhang, Zhenxi
AU - Xiong, Jianwen
AU - Xiong, Yuying
AU - Xiao, Hua
T1 - A novel biomaterial — Fe3O4:TiO2 core-shell nano particle with magnetic performance and high visible light photocatalytic activity
JO - Optical Materials
JF - Optical Materials
Y1 - 2008/10//
VL - 31
IS - 2
M3 - Article
SP - 380
EP - 384
SN - 09253467
AB - Abstract: Aiming at some disadvantages of TiO2 nano particle (TiO2 NP), this paper successfully prepared Fe3O4:TiO2 core-shell nano particle (Fe3O4:TiO2 core-shell NP) using homogeneous precipitation method. The prepared Fe3O4:TiO2 core-shell NP was characterized using XRD, TEM, UV–vis DRS, FT-IR, and VSM, respectively; the results show that Fe3O4:TiO2 core-shell NP is single dispersed with the diameter of 20nm on average. In contrast to the traditional TiO2 NP, Fe3O4:TiO2 core-shell NP generates red shift, and has higher absorption in visible region and greater photocatalytic activity, plus additional superparamagetism. In order to demonstrate the benefits of Fe3O4:TiO2 core-shell NP, we adopted Hela cells as a model to investigate the killing efficiency. The results show that Fe3O4:TiO2 core-shell NP is non-toxic, and much more efficient than traditional TiO2 NP combined with extra magnetic field. This shows that Fe3O4:TiO2 core-shell NP is a novel biomaterial with magnetic performance and high visible light photocatalytic activity. It would be a promising candidate in the field of malignant tumor therapy in future. [Copyright &y& Elsevier]
AB - Copyright of Optical Materials is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTOCATALYSIS
KW - NANOPARTICLES
KW - BIOMEDICAL materials
KW - TITANIUM dioxide
KW - FOURIER transform infrared spectroscopy
KW - TRANSMISSION electron microscopy
KW - HELA cells
KW - Fe3O4:TiO2 core-shell NP
KW - Homogeneous precipitation method
KW - Malignant tumor therapy
KW - Photocatalytic activity
N1 - Accession Number: 35327019; He, Qinghang 1,2 Zhang, Zhenxi 1; Email Address: zxzhang@mail.xjtu.edu.cn Xiong, Jianwen 3 Xiong, Yuying 3 Xiao, Hua 3; Affiliation: 1: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, PR China 2: Xiamen Food and Drug Administration, Xiamen 361004, PR China 3: Department of Physics, South China Normal University, Guangzhou 510631, PR China; Source Info: Oct2008, Vol. 31 Issue 2, p380; Subject Term: PHOTOCATALYSIS; Subject Term: NANOPARTICLES; Subject Term: BIOMEDICAL materials; Subject Term: TITANIUM dioxide; Subject Term: FOURIER transform infrared spectroscopy; Subject Term: TRANSMISSION electron microscopy; Subject Term: HELA cells; Author-Supplied Keyword: Fe3O4:TiO2 core-shell NP; Author-Supplied Keyword: Homogeneous precipitation method; Author-Supplied Keyword: Malignant tumor therapy; Author-Supplied Keyword: Photocatalytic activity; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.optmat.2008.05.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lawrence Yu
T1 - Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2008/10//
VL - 25
IS - 10
M3 - Article
SP - 2463
EP - 2463
SN - 07248741
N1 - Accession Number: 34327850; Lawrence Yu 1; Affiliation: 1: Office of Generic Drugs Food and Drug Administration 7519 Standish Place Rockville MD 20855 USA; Source Info: Oct2008, Vol. 25 Issue 10, p2463; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ogurtsov, Aleksey Y.
AU - Mariño-Ramírez, Leonardo
AU - Johnson, Gibbes R.
AU - Landsman, David
AU - Shabalina, Svetlana A.
AU - Spiridonov, Nikolay A.
T1 - Expression Patterns of Protein Kinases Correlate with Gene Architecture and Evolutionary Rates.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2008/10//
VL - 3
IS - 10
M3 - Article
SP - 1
EP - 17
PB - Public Library of Science
SN - 19326203
AB - Background: Protein kinase (PK) genes comprise the third largest superfamily that occupy ∼2% of the human genome. They encode regulatory enzymes that control a vast variety of cellular processes through phosphorylation of their protein substrates. Expression of PK genes is subject to complex transcriptional regulation which is not fully understood. Principal Findings: Our comparative analysis demonstrates that genomic organization of regulatory PK genes differs from organization of other protein coding genes. PK genes occupy larger genomic loci, have longer introns, spacer regions, and encode larger proteins. The primary transcript length of PK genes, similar to other protein coding genes, inversely correlates with gene expression level and expression breadth, which is likely due to the necessity to reduce metabolic costs of transcription for abundant messages. On average, PK genes evolve slower than other protein coding genes. Breadth of PK expression negatively correlates with rate of non-synonymous substitutions in protein coding regions. This rate is lower for high expression and ubiquitous PKs, relative to low expression PKs, and correlates with divergence in untranslated regions. Conversely, rate of silent mutations is uniform in different PK groups, indicating that differing rates of non-synonymous substitutions reflect variations in selective pressure. Brain and testis employ a considerable number of tissue-specific PKs, indicating high complexity of phosphorylation-dependent regulatory network in these organs. There are considerable differences in genomic organization between PKs up-regulated in the testis and brain. PK genes up-regulated in the highly proliferative testicular tissue are fast evolving and small, with short introns and transcribed regions. In contrast, genes up-regulated in the minimally proliferative nervous tissue carry long introns, extended transcribed regions, and evolve slowly. Conclusions/Significance: PK genomic architecture, the size of gene functional domains and evolutionary rates correlate with the pattern of gene expression. Structure and evolutionary divergence of tissue-specific PK genes is related to the proliferative activity of the tissue where these genes are predominantly expressed. Our data provide evidence that physiological requirements for transcription intensity, ubiquitous expression, and tissue-specific regulation shape gene structure and affect rates of evolution. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - GENETIC regulation
KW - GENETIC transcription
KW - PROTEIN kinases
KW - EVOLUTION (Biology)
KW - GENOMES
KW - PHOSPHORYLATION
KW - VARIATION (Biology)
KW - MUTATION (Biology)
N1 - Accession Number: 55701292; Ogurtsov, Aleksey Y. 1 Mariño-Ramírez, Leonardo 1 Johnson, Gibbes R. 2 Landsman, David 1 Shabalina, Svetlana A. 1; Email Address: nikolay.spiridonov@fda.hhs.gov Spiridonov, Nikolay A. 2; Email Address: shabalin@ncbi.nlm.nih.gov; Affiliation: 1: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America 2: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U. S. Food and Drug Administration, Bethesda, Maryland, United States of America; Source Info: 2008, Vol. 3 Issue 10, p1; Subject Term: GENE expression; Subject Term: GENETIC regulation; Subject Term: GENETIC transcription; Subject Term: PROTEIN kinases; Subject Term: EVOLUTION (Biology); Subject Term: GENOMES; Subject Term: PHOSPHORYLATION; Subject Term: VARIATION (Biology); Subject Term: MUTATION (Biology); Number of Pages: 17p; Illustrations: 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0003599
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105572391
T1 - Factors influencing the career aspirations and preferred modes of working in recent dental graduates in wales.
AU - Davies L
AU - Thomas DR
AU - Sandham SJ
AU - Treasure ET
AU - Chestnutt IG
Y1 - 2008/10//2008 Oct
N1 - Accession Number: 105572391. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Special Interest: Dental Care. NLM UID: 9617339.
KW - Career Planning and Development
KW - Contract Services -- Statistics and Numerical Data
KW - Dentists -- Statistics and Numerical Data
KW - Practice Patterns -- Statistics and Numerical Data
KW - Public Health Dentistry -- Statistics and Numerical Data
KW - Adult
KW - Female
KW - Male
KW - National Health Programs -- Statistics and Numerical Data
KW - Specialties, Dental -- Statistics and Numerical Data
KW - Wales
KW - Human
SP - 157
EP - 163
JO - Primary Dental Care: Journal of the Faculty of General Dental Practitioners
JF - Primary Dental Care: Journal of the Faculty of General Dental Practitioners
JA - PRIM DENT CARE
VL - 15
IS - 4
PB - Faculty of Dental Practitioners
AB - INTRODUCTION: In England and Wales, National Health Service (NHS) primary dental care services are now commissioned on a local basis. In planning for the future, it is important that commissioning authorities have a clear understanding of the perspectives of recent dental graduates: vocational dental practitioners (VDPs). OBJECTIVES: This study investigated the career aspirations and preferred modes of working of VDPs in Wales. METHODOLOGY: Data were collected via a postal questionnaire, comprising 37 closed and open questions, mailed to all 59 VDPs in Wales. RESULTS: A total of 53 (90%) VDPs participated, of whom 47 saw their future in general dental practice: 5, 35, and 7 indicating a preference to work in the NHS, mixed (NHS and private), and private sector, respectively. None selected the Community Dental Service as their preferred vocation. More than half of all respondents intended to undertake a postgraduate qualification within the next five years and 22 wished to specialise. Of the 53 VDPs, 44 were concerned that lack of NHS contracts would limit where they could practise, and agreed that family and other social commitments were a significant influence on choice of practice location. Access to high-quality premises and continuing professional development were agreed as important by 41 VDPs. A majority (37) agreed that private dentistry was an attractive alternative to NHS dentistry. Of the respondents, 38 (22 females, 16 males) expected to work part-time at some point in the future and 14 said they would consider a career outside dentistry. Only nine VDPs agreed that they would be happy working in a single-handed practice and even fewer (six) indicated they would be happy working for a corporate body. CONCLUSIONS: Numerous factors impact on the career aspirations of VDPs. These factors have been quantified in this study, and healthcare-commissioning bodies need to be aware of them when planning future dental care provision in Wales.
SN - 1355-7610
AD - National Public Health Service (Wales), Pontypool, UK.
U2 - PMID: 18826772.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105580636
T1 - An investigation on the biodynamic foundation of a rat tail vibration model.
AU - Welcome DE
AU - Krajnak K
AU - Kashon ML
AU - Dong RG
AU - Welcome, D E
AU - Krajnak, K
AU - Kashon, M L
AU - Dong, R G
Y1 - 2008/10//2008 Oct
N1 - Accession Number: 105580636. Language: English. Entry Date: 20090130. Revision Date: 20170228. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; UK & Ireland. NLM UID: 8908934.
KW - Models, Biological
KW - Motion
KW - Movement -- Physiology
KW - Physical Stimulation -- Methods
KW - Physics -- Methods
KW - Animal Studies
KW - Computer Simulation
KW - Male
KW - Rats
KW - Vibration
SP - 1127
EP - 1141
JO - Proceedings of the Institution of Mechanical Engineers -- Part H -- Journal of Engineering in Medicine (Professional Engineering Publishing)
JF - Proceedings of the Institution of Mechanical Engineers -- Part H -- Journal of Engineering in Medicine (Professional Engineering Publishing)
JA - PROC INST MECH ENG H
VL - 222
IS - 7
CY - Birmingham, Alabama
PB - Professional Engineering Publishing
AB - The objectives of this study are to examine the fundamental characteristics of the biodynamic responses of a rat tail to vibration and to compare them with those of human fingers. Vibration transmission through tails exposed to three vibration magnitudes (1 g, 5 g, and 10 g r.m.s.) at six frequencies (32 Hz, 63 Hz, 125 Hz, 160 Hz, 250 Hz, and 500 Hz) was measured using a laser vibrometer. A mechanical-equivalent model of the tail was established on the basis of the transmissibility data, which was used to estimate the biodynamic deformation and vibration power absorption at several representative locations on the tail. They were compared with those derived from a mechanical-equivalent model of human fingers reported in the literature. This study found that, similar to human fingers, the biodynamic responses of the rat tail depends on the vibration magnitude, frequency, and measurement location. With the restraint method used in this study, the natural frequency of the rat tail is in the range 161-368 Hz, which is mostly within the general range of human finger resonant frequencies (100-350 Hz). However, the damping ratios of the rat tail at the unconstrained locations are from 0.094 to 0.394, which are lower than those of human fingers (0.708-0.725). Whereas the biodynamic responses of human fingers at frequencies lower than 100 Hz could be significantly influenced by the biodynamics of the entire hand-arm system, the rat tail biodynamic responses can be considered independent of the rat body in the frequency range used in this study. Based on these findings it is concluded that, although there are some differences between the frequency dependences of the biodynamic responses of the rat tail and human fingers, the rat tail model can provide a practical and reasonable approach to examine the relationships between the biodynamic and biological responses at midrange to high frequencies, and to understand the mechanisms underlying vibration-induced finger disorders.
AD - Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, WV 26505, USA
AD - Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, WV 26505, USA. dwelcome@cdc.gov
U2 - PMID: 19024160.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105580636&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Knapper, C. M.
AU - Roderick, J.
AU - Smith, J.
AU - Temple, M.
AU - Birley, H. D. L.
T1 - Investigation of an HIV transmission cluster centred in South Wales.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2008/10//
VL - 84
IS - 5
M3 - Article
SP - 377
EP - 380
SN - 13684973
AB - Objective: To describe an HIV transmission cluster centred in South Wales by the analysis of partner notification outcomes and demographic characteristics of individuals identified in the sexual network. Methods: After diagnosis of the index case, HIV testing and partner notification were undertaken by Cardiff Genitourinary Medicine Clinic in collaboration with the local Health Protection Team, National Public Health Service for Wales and Terrence Higgins Trust Cymru. Rapid test and standard venepuncture methods were used for HIV screening and the resulting clinical and behavioural data were analysed. Results: Of the 123 individuals identified in the sexual network, all were men who had sex with men (MSM) except for seven men who self-identified as bisexual and five heterosexual women. Fifteen new cases of HIV were diagnosed; all were men. Partner notification outcomes are as follows: 104 provider referrals were made, 57 were successfully contacted with known outcomes, 14 were successfully contacted but with unknown outcomes and 33 were uncontactable. Fifteen patient referrals were made, 11 had known outcomes but four had unknown outcomes. Four patients self-referred. Eleven reported previous HIV diagnosis. The sexual network was distributed over South and West Wales extending into England, with high reported rates of unprotected anal intercourse, previous HIV tests and concurrent sexually transmitted infections. A one in four positive rate for those with a known HIV status outcome and a 68% provider referral success rate compares favourably with other studies. Conclusions: Partner notification revealed a relatively young, well-educated HIV network with high-risk behaviour and ongoing transmission despite previous knowledge and awareness of HIV. This analysis adds to the evidence supporting HIV partner notification in MSM. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Infections is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV infections -- Transmission
KW - HIV-positive gay men
KW - GAY people -- Sexual behavior
KW - SEXUALLY transmitted diseases -- Diagnosis
KW - WALES, South
N1 - Accession Number: 35008896; Knapper, C. M. 1; Email Address: carysknapper@cardiffandvale.wales.nhs.uk Roderick, J. 1 Smith, J. 2 Temple, M. 2 Birley, H. D. L. 1; Affiliation: 1: Department of Genitourinary Medicine, Cardiff Royal Infirmary, Cardiff, UK 2: Infection and Communicable Disease Service, National Public Health Service, Wales, UK; Source Info: Oct2008, Vol. 84 Issue 5, p377; Subject Term: HIV infections -- Transmission; Subject Term: HIV-positive gay men; Subject Term: GAY people -- Sexual behavior; Subject Term: SEXUALLY transmitted diseases -- Diagnosis; Subject Term: WALES, South; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1136/sti.2008.030536
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chakravarty, Aloka
AU - Sridhara, Rajeshwari
T1 - Use of progression-free survival as a surrogate marker in oncology trials: some regulatory issues.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2008/10//
VL - 17
IS - 5
M3 - Article
SP - 515
EP - 518
PB - Sage Publications, Ltd.
SN - 09622802
AB - There has been interest in using progression-free survival as a surrogate endpoint for overall survival in oncology clinical trials. In order to objectively define this endpoint, clear understanding of what progression means, how it is measured and what its implications are need to be discussed. This article discusses some regulatory aspects of using progression-free survival as an endpoint. [ABSTRACT FROM AUTHOR]
AB - Copyright of Statistical Methods in Medical Research is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ONCOLOGY -- Research
KW - COLON cancer
KW - CANCER treatment
KW - CANCER relapse
KW - BIOCHEMICAL markers
KW - MEDICAL statistics
N1 - Accession Number: 35355529; Chakravarty, Aloka 1; Email Address: aloka.chakravarty@fda.hhs.gov Sridhara, Rajeshwari 1; Affiliation: 1: Office of Biostatistics, Center for Drug Evaluation and Research, FDA, MD, USA; Source Info: Oct2008, Vol. 17 Issue 5, p515; Subject Term: ONCOLOGY -- Research; Subject Term: COLON cancer; Subject Term: CANCER treatment; Subject Term: CANCER relapse; Subject Term: BIOCHEMICAL markers; Subject Term: MEDICAL statistics; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105556437
T1 - Use of progression-free survival as a surrogate marker in oncology trials: some regulatory issues.
AU - Chakravarty A
AU - Sridhara R
Y1 - 2008/10//
N1 - Accession Number: 105556437. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9212457.
KW - Biological Markers
KW - Clinical Trials -- Legislation and Jurisprudence
KW - Disease Progression
KW - Government Regulations
KW - Survival Analysis
KW - Neoplasms -- Drug Therapy
KW - Oncology
KW - United States
SP - 515
EP - 518
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
JA - STAT METHODS MED RES
VL - 17
IS - 5
CY -
PB - Sage Publications, Ltd.
SN - 0962-2802
AD - Office of Biostatistics, Center for Drug Evaluation and Research, FDA, MD, USA. aloka.chakravarty@fda.hhs.gov.
U2 - PMID: 18285437.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Delany, Peter J.
AU - Shields, Joseph J.
AU - Willenbring, Mark L.
AU - Huebner, Robert B.
T1 - Expanding the Role of Health Services Research as a Tool to Reduce the Public Health Burden of Alcohol Use Disorders.
JO - Substance Use & Misuse
JF - Substance Use & Misuse
Y1 - 2008/10//
VL - 43
IS - 12/13
M3 - Article
SP - 1729
EP - 1746
PB - Taylor & Francis Ltd
SN - 10826084
AB - The public and private cost of “heavy alcohol use”1 is estimated to be more than 187 billion in lost productivity, health care and criminal justice expenditures, and other costs. This does not include the emotional and psychological costs to family, friends, and the community. Investments by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have led to a number of important advances in pharmacological and behavioral treatments for alcohol disorders. Yet, there continues to be a significant gap between research findings and progress in community-based care. Additionally, limited capacity, a lack of acknowledged standards, and a separation between the specialty substance use treatment sector and general medical practice contribute to this gap. As part of its ongoing efforts to encourage translation from clinical research to practice, NIAAA undertook a review of its alcohol related health services research program for the purpose of creating a vision for the next 10 yr that is sensitive to the changing needs of both the clinical and research communities. Central to the development of a new research agenda is a reconceptualization of alcohol use and misuse along a continuum that takes into account quantity and frequency of use as well as the consequences from “heavy use” and misuse of alcohol. This public health approach recommends a number of high priority areas to expand and improve the system of care for “heavy alcohol users” who may be at-risk or who may have developed an alcohol use disorder. These recommendations include research on dissemination and implementation of evidence-based practices, and improving access and utilization to care for individuals who are “heavy users.” The paper concludes by outlining some of the steps taken by NIAAA to further the continuing development of alcohol health services research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Substance Use & Misuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREVENTION of alcoholism
KW - GOVERNMENT policy
KW - HEALTH promotion
KW - MEDICAL care costs
KW - ALCOHOLISM -- Treatment
KW - PUBLIC health
KW - alcohol diagnosis
KW - alcohol user treatment
KW - context of treatment
KW - health services
KW - NATIONAL Institute on Alcohol Abuse & Alcoholism (U.S.)
N1 - Accession Number: 35275970; Delany, Peter J. 1; Email Address: Peter.Delany@samhsa.hhs.gov. Shields, Joseph J. 2,3 Willenbring, Mark L. 3 Huebner, Robert B. 3; Affiliation: 1: Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA 2: Catholic University of America, Washington, District of Columbia, USA 3: National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA; Source Info: 2008, Vol. 43 Issue 12/13, p1729; Subject Term: PREVENTION of alcoholism; Subject Term: GOVERNMENT policy; Subject Term: HEALTH promotion; Subject Term: MEDICAL care costs; Subject Term: ALCOHOLISM -- Treatment; Subject Term: PUBLIC health; Author-Supplied Keyword: alcohol diagnosis; Author-Supplied Keyword: alcohol user treatment; Author-Supplied Keyword: context of treatment; Author-Supplied Keyword: health services; Company/Entity: NATIONAL Institute on Alcohol Abuse & Alcoholism (U.S.); NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 18p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1080/10826080802345341
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35275970&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - JUN ZHANG
AU - SNYDER, RONALD D.
AU - HERMAN, EUGENE H.
AU - KNAPTON, ALAN
AU - HONCHEL, RONALD
AU - MILLER, TERRY
AU - ESPANDIARI, PARVANEH
AU - GOODSAID, FEDERICO M.
AU - ROSENBLUM, IRWIN Y.
AU - HANIG, JOSEPH P.
AU - SISTARE, FRANK D.
AU - WEAVER, JAMES L.
T1 - Histopathology of Vascular Injury in Sprague-Dawley Rats Treated with Phosphodiesterase IV Inhibitor SCH 351591 or SCH 534385.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/10//
VL - 36
IS - 6
M3 - Article
SP - 827
EP - 839
SN - 01926233
AB - Histopathological and immunohistochemical studies were conducted to characterize vascular injuries in rats treated with phosphodiesterase (PDE) IV inhibitors SCH 351591 or SCH 534385. Sprague-Dawley rats were administered PDE IV inhibitors by gavage at a range of doses and times. The two PDE IV inhibitors induced comparable levels of vascular injury, primarily in the mesentery and to a lesser extent in the pancreas, kidney, liver, small intestine, and stomach. Mesenteric vascular changes occurred as early as one hour, progressively developed over twenty-four to forty-eight hours, peaked at seventy-two hours, and gradually subsided from seven to nine days. The typical morphology of the vascular toxicity consisted of hemorrhage and necrosis of arterioles and arteries, microvascular injury, fibrin deposition, and perivascular inflammation of a variety of blood vessels. The incidence and severity of mesenteric vascular injury increased in a time- and dose-dependent manner in SCH 351591- or SCH 534385- treated rats. Mesenteric vascular injury was frequently associated with activation of mast cells (MC), endothelial cells (EC), and macrophages (MØ). Immunohistochemical studies showed increases in CD63 immunoreactivity of mesenteric MC and in nitrotyrosine immunoreactivity of mesenteric EC and MØ. The present study also provides a morphological and cellular basis for evaluating candidate biomarkers of drug-induced vascular injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Toxicology
KW - Biochemical markers
KW - Blood-vessels
KW - Phosphodiesterases
KW - Rats as laboratory animals
KW - Mesenteric blood vessels
KW - Mast cells
KW - Macrophages
KW - activation and degranulation of mast cell
KW - activation of endothelial cell and macrophage
KW - apoptosis of endothelial and smooth muscle cells
KW - arterial hemorrhage and necrosis
KW - nitrotyrosine
KW - peroxynitrite
N1 - Accession Number: 43517442; JUN ZHANG 1; Email Address: jun.zhang@fda.hhs.gov; SNYDER, RONALD D.; HERMAN, EUGENE H. 1; KNAPTON, ALAN 1; HONCHEL, RONALD 1; MILLER, TERRY 1; ESPANDIARI, PARVANEH 1; GOODSAID, FEDERICO M. 2; ROSENBLUM, IRWIN Y. 3; HANIG, JOSEPH P. 1; SISTARE, FRANK D. 4; WEAVER, JAMES L. 1; Affiliations: 1: Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 2: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 3: Kyowa Pharmaceutical Inc., Princeton, New Jersey, USA; 4: Merck Research Laboratories, West Point, Pennsylvania, USA; Issue Info: 2008, Vol. 36 Issue 6, p827; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Toxicology; Thesaurus Term: Biochemical markers; Subject Term: Blood-vessels; Subject Term: Phosphodiesterases; Subject Term: Rats as laboratory animals; Subject Term: Mesenteric blood vessels; Subject Term: Mast cells; Subject Term: Macrophages; Author-Supplied Keyword: activation and degranulation of mast cell; Author-Supplied Keyword: activation of endothelial cell and macrophage; Author-Supplied Keyword: apoptosis of endothelial and smooth muscle cells; Author-Supplied Keyword: arterial hemorrhage and necrosis; Author-Supplied Keyword: nitrotyrosine; Author-Supplied Keyword: peroxynitrite; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Illustrations: 4 Diagrams, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1177/0192623308322308
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - WEAVER, JAMES L.
AU - SNYDER, RONALD
AU - KNAPTON, ALAN
AU - HERMAN, EUGENE H.
AU - HONCHEL, RONALD
AU - MILLER, TERRY
AU - ESPANDIARI, PARVANEH
AU - SMITH, ROGER
AU - YI-ZHONG GU
AU - GOODSAID, FEDERICO M.
AU - ROSENBLUM, IRWIN Y.
AU - SISTARE, FRANK D.
AU - JUN ZHANG
AU - HANIG, JOSEPH
T1 - Biomarkers in Peripheral Blood Associated with Vascular Injury in Sprague-Dawley Rats Treated with the Phosphodiesterase IV Inhibitors SCH 351591 or SCH 534385.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/10//
VL - 36
IS - 6
M3 - Article
SP - 840
EP - 849
SN - 01926233
AB - Drug-associated vascular injury can be caused by phosphodiesterase (PDE) IV inhibitors and drugs from several other classes. The pathogenesis is poorly understood, but it appears to include vascular and innate immunological components. This research was undertaken to identify changes in peripheral blood associated with vascular injury caused by PDE IV inhibitors. We evaluated twelve proteins, serum nitrite, and leukocyte populations in peripheral blood of rats treated with experimental PDE IV inhibitors. We found that these compounds produced histological microvascular injury in a dose- and time-dependent manner. Measurement of these serum proteins showed changes in eight of the twelve examined. Changes were seen in the levels of: tissue inhibitor of metalloproteinase-1, α1-acid glycoprotein, GRO/CINC-1, vascular endothelial growth factor, C-reactive protein, haptoglobin, thrombomodulin, and interleukin-6. No changes were seen in levels of tumor necrosis factor-α, hepatocyte growth factor, nerve growth factor, and granulocyte-monocyte colony stimulating factor. Serum levels of nitrite were also increased. Circulating granulocyte numbers were increased, and lymphocyte numbers were decreased. The changes in these parameters showed both a dose- and time-dependent association with histopathologic changes. These biomarkers could provide an additional tool for the nonclinical and clinical evaluation of investigational compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - WOUNDS & injuries
KW - Blood-vessels
KW - Phosphodiesterases
KW - Proteins
KW - Leucocytes
KW - Metalloproteinases
KW - Glycoproteins
KW - Granulocytes
KW - biomarkers
KW - microvascular injury
KW - phosphodiesterase inhibitors
N1 - Accession Number: 43517443; WEAVER, JAMES L. 1; Email Address: james.weaver@fda.hhs.gov; SNYDER, RONALD 2; KNAPTON, ALAN 1; HERMAN, EUGENE H. 1; HONCHEL, RONALD 1; MILLER, TERRY 1; ESPANDIARI, PARVANEH 1; SMITH, ROGER 2; YI-ZHONG GU 2; GOODSAID, FEDERICO M. 3; ROSENBLUM, IRWIN Y. 4; SISTARE, FRANK D. 5; JUN ZHANG 1; HANIG, JOSEPH 1; Affiliations: 1: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 2: Schering-Plough Research Institute, Summit, New Jersey, USA; 3: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 4: Kyowa Pharmaceutical Inc., Princeton, New Jersey, USA; 5: Merck Research Laboratories, West Point, Pennsylvania, USA; Issue Info: 2008, Vol. 36 Issue 6, p840; Thesaurus Term: Biochemical markers; Thesaurus Term: WOUNDS & injuries; Subject Term: Blood-vessels; Subject Term: Phosphodiesterases; Subject Term: Proteins; Subject Term: Leucocytes; Subject Term: Metalloproteinases; Subject Term: Glycoproteins; Subject Term: Granulocytes; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: microvascular injury; Author-Supplied Keyword: phosphodiesterase inhibitors; Number of Pages: 10p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1177/0192623308322310
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Jun Zhang
AU - Shaw, Martin
AU - Goering, Peter L.
T1 - Renal Papillary Antigen-1 (RPA-1) Cross-Reactivity in Necrotic Renal Proximal Tubules: Significance of Immunohistochemistry and Histopathology.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2008/10//
VL - 36
IS - 6
M3 - Letter
SP - 891
EP - 893
SN - 01926233
AB - A response by Jun Zhang et al. to a letter to the editor about their article "Immunolocalization of Kim-1, RPA-1 and RPA-2 in Kidney Gentamicin-, Mercury-, or Chromium-Treated Rats: Relation to Renal Distribution of iNOS and Nitrotyrosine" which appeared in Volume 36, Number 3 issue is presented.
KW - Letters to the editor
KW - Immunohistochemistry
N1 - Accession Number: 43517455; Jun Zhang 1; Shaw, Martin; Goering, Peter L. 2; Affiliations: 1: Center for Drug Evaluation and Research, FDA; 2: Center for Devices and Radiological Health, FDA; Issue Info: 2008, Vol. 36 Issue 6, p891; Subject Term: Letters to the editor; Subject Term: Immunohistochemistry; Number of Pages: 3p; Illustrations: 1 Diagram, 1 Chart; Document Type: Letter
L3 - 10.1177/0192623308324960
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43517455&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2008-14889-004
AN - 2008-14889-004
AU - Pogribny, Igor P.
AU - Karpf, Adam R.
AU - James, Smitha R.
AU - Melnyk, Stepan
AU - Han, Tao
AU - Tryndyak, Volodymyr P.
T1 - Epigenetic alterations in the brains of fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2008/10//
VL - 1237
SP - 25
EP - 34
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Pogribny, Igor P., Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, US, 72079
N1 - Accession Number: 2008-14889-004. PMID: 18694733 Partial author list: First Author & Affiliation: Pogribny, Igor P.; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Choline; Diets; Folic Acid; Methionine. Minor Descriptor: Carbon. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2008.
AB - The maintenance of the cellular epigenomic landscape, which depends on the status of the one-carbon metabolic pathway, is essential for normal central nervous system development and function. In the present study, we examined the epigenetic alterations in the brains of Fisher 344 rats induced by the long-term administration of a diet lacking of essential one-carbon nutrients, methionine, choline, and folic acid. The results demonstrated that feeding a folate/methyl-deficient diet causes global DNA hypermethylation as indicated by an increase of genomic 5-methyl-2₂-deoxycytidine (5mdC) content and more importantly, by an increase of methylation within unmethylated CpG-rich DNA domains. Interestingly, these epigenetic changes were opposite to those observed in the livers of the same folate/methyl-deficient rats. The hypermethylation changes were associated with an increased protein expression of de novo DNA methyltransferase DNMT3a and methyl-CpG-binding protein 2. Additionally, the gene expression profiling identified 33 significantly up- or down-regulated genes (fold change ≥ 1.5 and p ≤ 0.05) in the brains of rats fed a folate/methyl-deficient diet for 36 weeks. Interestingly, we detected an up-regulation of regulatory factor X, 3 (Rfx3) gene, a sequence-specific DNA-binding protein, that mediates the transcriptional activation of silenced by methylation genes, which may be an adaptive protective brain response to hypermethylation. Together, these data suggest that the proper maintenance of the epigenomic landscape in normal brain depends on the adequate supply of essential nutrients involved in the metabolism of methyl groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epigenetic
KW - brain
KW - methyl-deficient diets
KW - one-carbon nutrients
KW - methionine
KW - choline
KW - folic acid
KW - 2008
KW - Brain
KW - Choline
KW - Diets
KW - Folic Acid
KW - Methionine
KW - Carbon
KW - 2008
DO - 10.1016/j.brainres.2008.07.077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14889-004&site=ehost-live&scope=site
UR - igor.pogribny@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14889-006
AN - 2008-14889-006
AU - Bagnyukova, Tetyana V.
AU - Powell, Christine L.
AU - Pavliv, Oleksandra
AU - Tryndyak, Volodymyr P.
AU - Pogribny, Igor P.
T1 - Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet.
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2008/10//
VL - 1237
SP - 44
EP - 51
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Bagnyukova, Tetyana V., Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, US, 72079
N1 - Accession Number: 2008-14889-006. PMID: 18694737 Partial author list: First Author & Affiliation: Bagnyukova, Tetyana V.; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, US. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Brain; Diets; DNA; Stress; Oxidative Stress. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2008.
AB - The age-associated decline in cellular antioxidant defenses and resultant accumulation of DNA damage in central nervous system has been mechanistically implicated in the etiology and pathogenesis of neurodegenerative diseases. Neurons possess a high metabolic activity and are especially vulnerable to the long-term effects of continuous exposure to endogenous reactive oxygen species. It is well recognized that adequate availability of essential nutrients involved in cellular one-carbon metabolism is essential for normal brain development and function. Additionally, the synthesis of the primary low-molecular cellular antioxidant glutathione is inter-dependently linked to one-carbon metabolic pathway. Thus, any aberrant disruptions in one-carbon metabolism can result in potentially deleterious effects including cell death as a result of an imbalance in the cellular redox state. Hence, in the present study, we examined the long-term effects of a folate/methyl-deficient (FMD) diet on cellular antioxidant defenses and DNA damage in the rat brain. Feeding male Fisher 344 rats a FMD diet resulted in perturbations in the levels of one-carbon metabolites along with induction of oxidative stress and oxidative DNA damage in the brain. This was evidenced by a decrease in the reduced oxidized/glutathione ratio, imbalance of cellular antioxidant defense system; specifically, altered activity and expression of antioxidant enzymes Mn-containing superoxide dismutase (Mn-SOD), catalase, and glutathione peroxidase (GPX), increased accumulation of oxidative DNA lesions, 8-hydroxydeoxyguanosine (8-OH-dG) and DNA single-strand breaks, even in the presence of increased expression of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase beta (Polβ), and apoptosis in the brains of folate/methyl-deficient rats. These results indicate that chronic methyl group deficiency leads to an imbalance in cellular antioxidant defense systems, increased oxidative stress, and apoptosis. Any of these events may compromise normal central nervous system function and contribute to the development of various neurological, behavioral, and neurocognitive dysfunctions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oxidative stress
KW - DNA damage
KW - rats
KW - brain
KW - folate deficient diet
KW - methyl-deficient diet
KW - 2008
KW - Brain
KW - Diets
KW - DNA
KW - Stress
KW - Oxidative Stress
KW - Rats
KW - 2008
DO - 10.1016/j.brainres.2008.07.073
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14889-006&site=ehost-live&scope=site
UR - igor.pogribny@fda.hhs.gov
UR - tetyana.bagnyukova@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17681-008
AN - 2008-17681-008
AU - Kaida, Kosuke
AU - Åkerstedt, Torbjörn
AU - Takahashi, Masaya
AU - Vestergren, Peter
AU - Gillberg, Mats
AU - Lowden, Arne
AU - Kecklund, Göran
AU - Portin, Christian
T1 - Performance prediction by sleepiness-related subjective symptoms during 26-hour sleep deprivation.
JF - Sleep and Biological Rhythms
JO - Sleep and Biological Rhythms
JA - Sleep Biol Rhythms
Y1 - 2008/10//
VL - 6
IS - 4
SP - 234
EP - 241
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1446-9235
SN - 1479-8425
AD - Kaida, Kosuke, 3-65-305 Yamanote, Toyota, Aichi, Japan, 471-0833
N1 - Accession Number: 2008-17681-008. Partial author list: First Author & Affiliation: Kaida, Kosuke; Stress Research Institute, Stockholm University, Stockholm, Sweden. Other Publishers: Blackwell Publishing; Springer. Release Date: 20091102. Correction Date: 20160502. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Performance; Sleep Deprivation; Sleepiness; Symptoms. Classification: Physiological Processes (2540). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Karolinska Sleepiness Scale; Subjective Symptom Questionnaire. Methodology: Empirical Study; Quantitative Study. Page Count: 8. Issue Publication Date: Oct, 2008. Publication History: First Posted Date: Aug 16, 2008. Copyright Statement: The Authors. 2008.
AB - Sleepiness is a major cause of lower productivity and higher risk of accidents in various work situations. Developing sleepiness monitoring techniques is important to improve work efficiency and to reduce accident risk, so that people can take a rest/break in appropriate timing before an accident or a mistake occurs. The aims of the present study are (1) to explain subjective sleepiness using sleep-related symptoms, and (2) to examine which symptoms are useful to predict performance errors. Participants were healthy paid volunteers (six males, six females; mean ± SD, 31.5 ± 10.74 years). Participants took part in 26-h sleep deprivation. During sleep deprivation, they carried out several performance tasks every 3 h and an hourly rating of questionnaires to evaluate subjective symptoms including two types of Karolinska sleepiness scale (KSS). The present study confirmed that performance errors can be predicted by subjective symptoms. While mental fatigue was correlated to KSS scores linearly, eye-related subjective symptoms showed quadratic correlations to KSS. By taking into consideration this noteworthy relationship between subjective symptoms and sleepiness, more accurate introspection of sleepiness and performance errors prediction (detection) may be possible. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - performance
KW - sleepiness
KW - subjective symptoms
KW - sleep deprivation
KW - 2008
KW - Performance
KW - Sleep Deprivation
KW - Sleepiness
KW - Symptoms
KW - 2008
DO - 10.1111/j.1479-8425.2008.00367.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17681-008&site=ehost-live&scope=site
UR - ORCID: 0000-0003-1442-3939
UR -
UR - kaida-kosuke@umin.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-13178-010
AN - 2008-13178-010
AU - Korthuis, Philip Todd
AU - Josephs, Joshua S.
AU - Fleishman, John A.
AU - Hellinger, James
AU - Himelhoch, Seth
AU - Chander, Geetanjali
AU - Morse, Elizabeth B.
AU - Gebo, Kelly A.
T1 - Substance abuse treatment in human immunodeficiency virus: The role of patient-provider discussions.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2008/10//
VL - 35
IS - 3
SP - 294
EP - 303
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Korthuis, Philip Todd, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Mail Code L-475, Portland, OR, US, 97239-3098
N1 - Accession Number: 2008-13178-010. PMID: 18329222 Partial author list: First Author & Affiliation: Korthuis, Philip Todd; Department of Medicine, Oregon Health and Science University, Portland, OR, US. Institutional Authors: HIV Research Network. Release Date: 20081013. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: International AIDS Conference, Aug, 2006, Toronto, ON, Canada. Grant Information: Gebo, Kelly A. Conference Note: Preliminary results were presented in abstract form at the aforementioned conference and the annual Society of General Internal Medicine meeting (April 2007, Toronto, Canada). Major Descriptor: Drug Abuse; Drug Rehabilitation; HIV; Risk Taking; Therapeutic Processes. Minor Descriptor: Health Care Utilization. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2008.
AB - Substance abuse treatment is associated with decreases in human immunodeficiency virus (HIV) risk behavior and can improve HIV outcomes. The purpose of this study was to examine factors associated with substance abuse treatment utilization, including patient-provider discussions of substance use issues. We surveyed 951 HIV-infected adults receiving care at 14 HIV Research Network primary care sites regarding drug and alcohol use, substance abuse treatment, and provider discussions of substance use issues. Although 71% reported substance use, only 24% reported receiving substance abuse treatment and less than half reported discussing substance use issues with their HIV providers. In adjusted logistic regression models, receipt of substance abuse treatment was associated with patient-provider discussions. Patient-provider discussions of substance use issues were associated with current drug use, hazardous or binge drinking, and Black race or ethnicity, though substance use was comparable between Blacks and Whites. These data suggest potential opportunities for improving engagement in substance abuse treatment services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human immunodeficiency virus
KW - substance abuse treatment
KW - HIV risk behavior
KW - patient-provider discussions
KW - substance use issues
KW - treatment utilization
KW - 2008
KW - Drug Abuse
KW - Drug Rehabilitation
KW - HIV
KW - Risk Taking
KW - Therapeutic Processes
KW - Health Care Utilization
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290-01-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Grant: R01 AG026250. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Grant: K23 AA015313. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: K23-DA00523; K23-DA019809; K23-DA019820. Recipients: No recipient indicated
U1 - Sponsor: Johns Hopkins University. Other Details: Richard Ross Clinician Scientist Award. Recipients: Gebo, Kelly A.
DO - 10.1016/j.jsat.2007.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13178-010&site=ehost-live&scope=site
UR - korthuis@ohsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16763-004
AN - 2008-16763-004
AU - Weld, C. P. T. Konstantine Keian
AU - Padden, Diane
AU - Ramsey, Gloria
AU - Garmon Bibb, Sandra C.
T1 - A framework for guiding health literacy research in populations with universal access to healthcare.
JF - Advances in Nursing Science
JO - Advances in Nursing Science
JA - ANS Adv Nurs Sci
Y1 - 2008/10//Oct-Dec, 2008
VL - 31
IS - 4
SP - 308
EP - 318
CY - US
PB - Lippincott Williams & Wilkins
SN - 0161-9268
SN - 1550-5014
AD - Weld, C. P. T. Konstantine Keian, 17211 Palomino CT, Olney, MD, US, 20852
N1 - Accession Number: 2008-16763-004. PMID: 19033746 Partial author list: First Author & Affiliation: Weld, C. P. T. Konstantine Keian; US Public Health Service, Graduate School of Nursing, Uniformed Services University of the Health Science, Olney, MD, US. Release Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Nursing; Health Literacy. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 11. Issue Publication Date: Oct-Dec, 2008. Copyright Statement: Wolters Kluwer Health | Lippincott Williams & Wilkins. 2008.
AB - At least one third of the US population suffers from limited health literacy, which has been linked to poorer health status, higher costs, and individuals who are socio economically disadvantaged. However, research and the development of theoretical frameworks to study health literacy have only recently begun to occur. The purpose of this article is to describe theoretical frameworks that have either been used or may be used to guide health literacy research and to identify implications for nursing research and practice related to an adaptation of a health literacy framework developed specifically for conducting research in populations with universal access to healthcare. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health literacy research
KW - health care
KW - health education
KW - health knowledge
KW - 2008
KW - Experimentation
KW - Nursing
KW - Health Literacy
KW - 2008
DO - 10.1097/01.ANS.0000341411.25048.91
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16763-004&site=ehost-live&scope=site
UR - kweld@usubs.mil
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14334-003
AN - 2008-14334-003
AU - Clark, Hewitt B.
AU - Koroloff, Nancy
AU - Geller, Jeffrey
AU - Sondheimer, Diane L.
T1 - Research on transition to adulthood: Building the evidence base to inform services and supports for youth and young adults with serious mental health disorders.
T3 - Transition to adulthood research
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2008/10//
VL - 35
IS - 4
SP - 365
EP - 372
CY - Germany
PB - Springer
SN - 1094-3412
AD - Clark, Hewitt B., National Center on Youth Transition for Behavioral Health, NCYT System Development and Research Team, Florida Mental Health Institute, University of South Florida, 13301 Bruce B. Downs Blvd., MHC 2332, Tampa, FL, US, 33612-3807
N1 - Accession Number: 2008-14334-003. PMID: 18726695 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Clark, Hewitt B.; National Center on Youth Transition for Behavioral Health, NCYT System Development and Research Team, Florida Mental Health Institute, University of South Florida, Tampa, FL, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adult Development; Experimentation; Life Changes; Mental Disorders; Mental Health Services. Minor Descriptor: Evidence Based Practice; Mental Health; Policy Making; Program Development. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2008.
AB - Since the mid-1990s, research has established a clear picture of the poor real-life outcomes achieved by transition-age youth and young adults who have been diagnosed with a serious mental health disorder. The purpose of this article is to: (1) introduce the reader to the other eight articles in this special issue on Transition to Adulthood Research; (2) illustrate how each is contributing to the research base available to more fully understand these challenges as well as guide the creation of developmentally appropriate and effective services and supports for youth and young adults and their families; and (3) suggest future directions for continuing to advance this field of research and program implementation to improve outcomes though practice and policy improvements. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adulthood transition
KW - young adults
KW - mental health disorders
KW - program implementation
KW - policy improvements
KW - youths
KW - research
KW - 2008
KW - Adult Development
KW - Experimentation
KW - Life Changes
KW - Mental Disorders
KW - Mental Health Services
KW - Evidence Based Practice
KW - Mental Health
KW - Policy Making
KW - Program Development
KW - 2008
DO - 10.1007/s11414-008-9140-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14334-003&site=ehost-live&scope=site
UR - diane.sondheimer@samhsa.hhs.gov
UR - Jeffrey.Geller@umassmed.edu
UR - koroloff@pdx.edu
UR - clark@fmhi.usf.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14866-002
AN - 2008-14866-002
AU - Blitz, Cynthia L.
AU - Wolff, Nancy
AU - Shi, Jing
T1 - Physical victimization in prison: The role of mental illness.
JF - International Journal of Law and Psychiatry
JO - International Journal of Law and Psychiatry
JA - Int J Law Psychiatry
Y1 - 2008/10//
VL - 31
IS - 5
SP - 385
EP - 393
CY - Netherlands
PB - Elsevier Science
SN - 0160-2527
SN - 1873-6386
AD - Blitz, Cynthia L., Institute for Health, Health Care Policy, and Aging Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2008-14866-002. PMID: 18809210 Partial author list: First Author & Affiliation: Blitz, Cynthia L.; Center for Mental Health Services, Rutgers University, New Brunswick, NJ, US. Release Date: 20081124. Correction Date: 20170206. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Prisoners; Prisons; Victimization; Violence. Classification: Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 2008.
AB - This study compares prison physical victimization rates (inmate-on-inmate and staff-on-inmate) for people with mental disorder to those without mental disorder in a state prison system. Inmate subjects were drawn from 14 adult prisons operated by a single mid-Atlantic State. A sample of 7528 subjects aged 18 or older (7221 men and 564 women) completed an audio-computer administered survey instrument. Mental disorder was based on self-reported mental health treatment ever for particular mental disorders. Approximately one-quarter of the sample reported some prior treatment for schizophrenia, bipolar disorder, depression, PTSD, or anxiety disorder. Rates of physical victimization for males with any mental disorder were 1.6 times (inmate-on-inmate) and 1.2 times (staff-on-inmate) higher than that of males with no mental disorder. Female inmates with mental disorder were 1.7 times more likely to report being physically victimized by another inmate than did their counterparts with no mental disorder. Overall, both males and females with mental disorder are disproportionately represented among victims of physical violence inside prison. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - physical victimization
KW - prisons
KW - mental disorder
KW - inmate subjects
KW - physical violence
KW - 2008
KW - Mental Disorders
KW - Prisoners
KW - Prisons
KW - Victimization
KW - Violence
KW - 2008
U1 - Sponsor: National Institute of Mental Health, US. Grant: P-20-MH-66170. Recipients: No recipient indicated
DO - 10.1016/j.ijlp.2008.08.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14866-002&site=ehost-live&scope=site
UR - clblitz@rci.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02318-007
AN - 2009-02318-007
AU - Otsuka, Yasumasa
AU - Suzuki, Ayako
AU - Takada, Misato
AU - Tomotake, Sawako
AU - Nakata, Akinori
T1 - The Japanese version of the Coping Orientation to Problems Expereinced: A study of Japanese schoolteachers.
JF - Psychological Reports
JO - Psychological Reports
JA - Psychol Rep
Y1 - 2008/10//
VL - 103
IS - 2
SP - 395
EP - 405
CY - US
PB - Psychological Reports
SN - 0033-2941
SN - 1558-691X
AD - Otsuka, Yasumasa, Hiroshima University, Graduate School of Education, 1-1-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, Japan, 739-8524
N1 - Accession Number: 2009-02318-007. PMID: 19102462 Partial author list: First Author & Affiliation: Otsuka, Yasumasa; Graduate School of Education, Hiroshima University, Hiroshima, Japan. Other Publishers: Sage Publications. Release Date: 20090706. Correction Date: 20151019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Coping Behavior; Problem Solving; Teachers; Test Reliability; Test Validity. Minor Descriptor: Factor Analysis. Classification: Personality Scales & Inventories (2223); Educational Administration & Personnel (3510). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Coping Orientation to Problems Experienced Inventory; Coping Inventory of Stressful Situations; Perceived Control Measure DOI: 10.1037/t11158-000; Rosenberg Self-Esteem Scale DOI: 10.1037/t01038-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 2008. Copyright Statement: Psychological Reports. 2008.
AB - To investigate the internal consistency reliability and three types of validity of the Coping Orientation to Problems Experienced (COPE), a survey was conducted among 209 English schoolteachers in Japan. The Japanese version of the COPE Inventory was developed through a back-translation process. Cronbach coefficients alpha for the Japanese version were above .70 for all subscales except five, including Acceptance and Restraint, so internal consistencies for these five were insufficient. Goodness of fit indexes for a confirmatory factor analysis were acceptable except for the Comparative Fit Index. Scores on COPE subscales were significantly correlated with scores on other tests (29 of 75 correlations were in the expected directions). Further exploration is required for several subscales and for generalization to Japanese-speaking populations in careers other than teaching to ensure the Japanese version of die COPE will be useful in assessing coping strategies. Given the limitations, present data for Japanese teachers are encouraging. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Japanese version
KW - Coping Orientation to Problems Experienced
KW - Japanese school teachers
KW - internal consistency
KW - test validity
KW - test reliability
KW - factor analysis
KW - 2008
KW - Coping Behavior
KW - Problem Solving
KW - Teachers
KW - Test Reliability
KW - Test Validity
KW - Factor Analysis
KW - 2008
U1 - Sponsor: Ministry of Education, Culture, Sports, Science and Technology, Japan. Grant: 17790401. Other Details: Grant-in-Aid for Young Scientists (B). Recipients: No recipient indicated
DO - 10.2466/PR0.103.6.395-405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02318-007&site=ehost-live&scope=site
UR - yasumasa-otsuka@hiroshima-u.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14334-010
AN - 2008-14334-010
AU - Manteuffel, Brigitte
AU - Stephens, Robert L.
AU - Sondheimer, Diane L.
AU - Fisher, Sylvia K.
T1 - Characteristics, service experiences, and outcomes of transition-aged youth in systems of care: Programmatic and policy implications.
T3 - Transition to adulthood research
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2008/10//
VL - 35
IS - 4
SP - 469
EP - 487
CY - Germany
PB - Springer
SN - 1094-3412
AD - Manteuffel, Brigitte, Macro International Inc., 3 Corporate Square, Suite 370, Atlanta, GA, US, 30329
N1 - Accession Number: 2008-14334-010. PMID: 18618264 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Manteuffel, Brigitte; Macro International Inc., Atlanta, GA, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20090316. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Development; Health Care Services; Life Changes; Policy Making; Program Development. Minor Descriptor: Age Differences; Client Characteristics; Experiences (Events); Health Care Utilization; Treatment Outcomes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Education Questionnaire; Delinquency Survey; Multi-sector Service Contacts Form; Restrictedness of Living Environments Scale-Revised; Child and Adolescent Functional Assessment Scale; Behavioral and Emotional Rating Scale; Child Behavior Checklist; Descriptive Information Questionnaire DOI: 10.1037/t45162-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: Oct, 2008.
AB - This article examines data for 8,484 transition-aged youth (TAY) in different age groups who received services in 45 federally funded systems of care between 1997 and 2006. Data from the national evaluation of these systems of care were used to compare descriptive and clinical characteristics at intake of TAY aged 14-15, 16-17, and 18 years, and service use and outcomes of TAY aged 14-15 and 16-17 at 6 and 12 months after system of care intake. Few studies have examined outcomes of TAY. The large national evaluation database provides a unique opportunity to examine outcomes for TAY in relation to increases in age. Results revealed differences in severity and type of behavioral and emotional problems, living situations, access to Medicaid, service use, and outcomes among younger and older youth. Findings support the need to enhance access to services for older TAY and to customize services to the unique needs of each age group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - service experiences
KW - transition-aged youths
KW - program implications
KW - policy implications
KW - age differences
KW - systems of care
KW - clinical characteristics
KW - treatment outcomes
KW - 2008
KW - Adolescent Development
KW - Health Care Services
KW - Life Changes
KW - Policy Making
KW - Program Development
KW - Age Differences
KW - Client Characteristics
KW - Experiences (Events)
KW - Health Care Utilization
KW - Treatment Outcomes
KW - 2008
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: 280-97-8014; 280-00-8040; 280-99-8023. Other Details: Macro International Inc.. Recipients: No recipient indicated
DO - 10.1007/s11414-008-9130-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14334-010&site=ehost-live&scope=site
UR - Sylvia.Fisher@samhsa.hhs.gov
UR - Diane.Sondheimer@samhsa.hhs.gov
UR - Robert.L.Stephens@macrointernational.com
UR - Brigitte.A.Manteuffel@macrointernational.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14888-013
AN - 2008-14888-013
AU - Turk, Dennis C.
AU - Dworkin, Robert H.
AU - McDermott, Michael P.
AU - Bellamy, Nicholas
AU - Burke, Laurie B.
AU - Chandler, Julie M.
AU - Cleeland, Charles S.
AU - Cowan, Penney
AU - Dimitrova, Rozalina
AU - Farrar, John T.
AU - Hertz, Sharon
AU - Heyse, Joseph F.
AU - Iyengar, Smriti
AU - Jadad, Alejandro R.
AU - Jay, Gary W.
AU - Jermano, John A.
AU - Katz, Nathaniel P.
AU - Manning, Donald C.
AU - Martin, Susan
AU - Max, Mitchell B.
AU - McGrath, Patrick
AU - McQuay, Henry J.
AU - Quessy, Steve
AU - Rappaport, Bob A.
AU - Revicki, Dennis A.
AU - Rothman, Margaret
AU - Stauffer, Joseph W.
AU - Svensson, Ola
AU - White, Richard E.
AU - Witter, James
T1 - Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations.
JF - Pain
JO - Pain
JA - Pain
Y1 - 2008/10//
VL - 139
IS - 3
SP - 485
EP - 493
CY - Netherlands
PB - Elsevier Science
SN - 0304-3959
SN - 1872-6623
AD - Turk, Dennis C., Department of Anesthesiology, University of Washington, P.O. Box 356540, Seattle, WA, US, 98195
N1 - Accession Number: 2008-14888-013. PMID: 18706763 Partial author list: First Author & Affiliation: Turk, Dennis C.; Department of Anesthesiology, University of Washington, Seattle, WA, US. Other Publishers: Lippincott Williams & Wilkins. Release Date: 20091123. Correction Date: 20160421. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Pain; Pain Measurement; Treatment Effectiveness Evaluation. Classification: Medical Treatment of Physical Illness (3363); Research Methods & Experimental Design (2260). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 2008. Publication History: Accepted Date: Jun 30, 2008; Revised Date: Jun 11, 2008; First Submitted Date: Mar 12, 2008. Copyright Statement: All rights reserved. International Association for the Study of Pain. 2008.
AB - The increasing complexity of randomized clinical trials and the practice of obtaining a wide variety of measurements from study participants have made the consideration of multiple endpoints a critically important issue in the design, analysis, and interpretation of clinical trials. Failure to consider important outcomes can limit the validity and utility of clinical trials; specifying multiple endpoints for the evaluation of treatment efficacy, however, can increase the rate of false positive conclusions about the efficacy of a treatment. We describe the use of multiple endpoints in the design, analysis, and interpretation of pain clinical trials, and review available strategies and methods for addressing multiplicity. To decrease the probability of a Type I error (i.e., the likelihood of obtaining statistically significant results by chance) in pain clinical trials, the use of gatekeeping procedures and other methods that correct for multiple analyses is recommended when a single primary endpoint does not adequately reflect the overall benefits of treatment. We emphasize the importance of specifying in advance the outcomes and clinical decision rule that will serve as the basis for determining that a treatment is efficacious and the methods that will be used to control the overall Type I error rate. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - clinical trials
KW - pain treatment efficacy evaluation
KW - multiple endpoints
KW - Initiative on Methods
KW - Measurement and Pain Assessment in Clinical Trials
KW - 2008
KW - Clinical Trials
KW - Pain
KW - Pain Measurement
KW - Treatment Effectiveness Evaluation
KW - 2008
U1 - Sponsor: Allergan. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Alpharma. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: AstraZeneca. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Celgene. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Cephalon. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Eli Lilly. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Endo. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: GlaxoSmithKline. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Johnson & Johnson. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Merck. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Pfizer. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
U1 - Sponsor: Schwarz Pharma. Other Details: University of Rochester Office of Professional Education. Recipients: No recipient indicated
DO - 10.1016/j.pain.2008.06.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14888-013&site=ehost-live&scope=site
UR - turkdc@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14128-003
AN - 2008-14128-003
AU - Basu, Jayasree
AU - Mobley, Lee R.
T1 - Trends in racial disparities among the elderly for selected procedures.
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2008/10//
VL - 65
IS - 5
SP - 617
EP - 637
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
AD - Basu, Jayasree, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2008-14128-003. PMID: 18490701 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Basu, Jayasree; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: National Leadership Summit on Eliminating Racial & Ethnic Disparities in Health, Jan, 2006, Office of Minority Health, Washington, DC, US. Conference Note: An earlier version of the article was presented at the aforementioned conference and the Academy Health annual research meeting. Major Descriptor: Health Care Utilization; Heart Surgery; Joints (Anatomy); Racial and Ethnic Differences; Surgery. Minor Descriptor: Trends. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 21. Issue Publication Date: Oct, 2008. Copyright Statement: Sage Publications. 2008.
AB - The authors examine trends over 1997-2001 in racial or ethnic disparities in the utilization of three costly, referral-sensitive procedures among the elderly—coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), and hip/joint replacement. Using a multivariate framework, they undertake a simultaneous examination of the relationships between patient, local area context, and health systems on these admission types after comparing them to a control group. This period spans the implementation of the Balanced Budget Act and a major Department of Health and Human Services initiative to reduce disparities in cardiovascular and other diseases. Findings suggest increasing disparities for African Americans relative to Whites in their lower utilization of CABG and PTCA over time, and increasing disparities in the utilization of hip/joint replacement among other races’ relative to Whites. The authors find that racial or ethnic disparities in use of referral-sensitive procedures did not narrow over 1997-2001. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial disparities
KW - coronary artery bypass grafting
KW - percutaneous transluminal coronary angioplasty
KW - hip or joint replacement
KW - 2008
KW - Health Care Utilization
KW - Heart Surgery
KW - Joints (Anatomy)
KW - Racial and Ethnic Differences
KW - Surgery
KW - Trends
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality, US. Recipients: No recipient indicated
U1 - Sponsor: RTI International. Recipients: No recipient indicated
DO - 10.1177/1077558708318284
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14128-003&site=ehost-live&scope=site
UR - Jayasree.basu@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-001
AN - 2008-14322-001
AU - Fein, Sara B.
AU - Grummer-Strawn, Laurence M.
AU - Raju, Tonse N. K.
T1 - Infant feeding and care practices in the United States: Results from the Infant Feeding Practices Study II.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S25
EP - S27
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Fein, Sara B., Food and Drug Administration, Centre for Food Safety Applied Nutrition, 5100 Paint Branch Pkwy, HFS 020, Colllege Park, MD, US, 20740
N1 - Accession Number: 2008-14322-001. Partial author list: First Author & Affiliation: Fein, Sara B.; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, US. Release Date: 20090223. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bottle Feeding; Breast Feeding; Infant Development; Nutrition. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Location: US. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 2008.
AB - This supplemental issue of Pediatrics presents the first set of results from the Infant Feeding Practices Study II (IFPS II), which were chosen to cover a wide range of the topics included in the study. The 13 articles in this supplement provide results on several feeding issues: breastfeeding patterns, intensity, and duration; reasons for stopping breastfeeding; and transitional and complementary feeding, including provision of iron-rich foods and supplements to breastfed infants. Several of the articles examine mothers' adherence to recommendations for infant feeding and care. This set of articles provides insight into a wide range of practical issues that affect mothers and infants. However, we believe that this is only the beginning; the data sets from the IFPS II are available from the CDC for the scientific community to pursue additional analyses and research using this rich source of information. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant feeding practices
KW - care practices
KW - mothers
KW - breastfeeding
KW - 2008
KW - Bottle Feeding
KW - Breast Feeding
KW - Infant Development
KW - Nutrition
KW - 2008
U1 - Sponsor: US Department of Health and Human Services, Food and Drug Administration, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Centers for Disease Control and Prevention, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Office of Women's Health. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Office of Dietary Supplements, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, National Cancer Institute, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Health Services and Resources Administration, Maternal and Child Health Bureau, US. Recipients: No recipient indicated
U1 - Sponsor: US Department of Agriculture, Economic Research Service, Food and Nutrition Service, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-001&site=ehost-live&scope=site
UR - sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-003
AN - 2008-14322-003
AU - DiGirolamo, Ann M.
AU - Grummer-Strawn, Laurence M.
AU - Fein, Sara B.
T1 - Effect of maternity-care practices on breastfeeding.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S43
EP - S49
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - DiGirolamo, Ann M., Emory University, Hubert Department of Global Health, 1518 Clifton Rd, NE, Atlanta, GA, US, 30307
N1 - Accession Number: 2008-14322-003. Partial author list: First Author & Affiliation: DiGirolamo, Ann M.; Hubert Department of Global Health, Emory University, Atlanta, GA, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Hospitals; Mothers; Perinatal Period. Classification: Inpatient & Hospital Services (3379); Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2008.
AB - Objective: Our goal was to assess the impact of 'Baby-Friendly' hospital practices and other maternity-care practices experienced by mothers on breastfeeding duration. Methods: This analysis of the Infant Feeding Practices Study II focused on mothers who initiated breastfeeding and intended prenatally to breastfeed for >2 months, with complete data on all variables (n = 1907). Predictor variables included indicators of 6 'Baby-Friendly' practices (breastfeeding initiation with in 1 hour of birth, giving only breast milk, rooming in, breastfeeding on demand, no pacifiers, fostering breastfeeding support groups) along with several other maternity-care practices. The main outcome measure was breastfeeding termination before 6 weeks. Results: Only 8.1% of the mothers experienced all 6 'Baby-Friendly' practices. The practices most consistently associated with breastfeeding beyond 6 weeks were initiation within 1 hour of birth, giving only breast milk, and not using pacifiers. Bringing the infant to the room for feeding at night if not rooming in and not giving pain medications to the mother during delivery were also protective against early breastfeeding termination. Compared with the mothers who experienced all 6 'Baby-Friendly' practices, mothers who experienced none were ∼13 times more likely to stop breastfeeding early. Additional practices decreased the risk for early termination. Conclusions: Increased 'Baby-Friendly' hospital practices, along with several other maternity-care practices, improve the chances of breastfeeding beyond 6 weeks. The need to work with hospitals to implement these practices continues to exist, as illustrated by the small proportion of mothers who reported experiencing all 6 of the 'Baby-Friendly' hospital practices measured in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - maternity-care practices
KW - breastfeeding duration & termination
KW - mothers
KW - baby-friendly hospital policies & practices
KW - 2008
KW - Breast Feeding
KW - Hospitals
KW - Mothers
KW - Perinatal Period
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315e
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-003&site=ehost-live&scope=site
UR - adigiro@sph.emory.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-004
AN - 2008-14322-004
AU - Shealy, Katherine R.
AU - Scanlon, Kelley S.
AU - Labiner-Wolfe, Judith
AU - Fein, Sara B.
AU - Grummer-Strawn, Laurence M.
T1 - Characteristics of breastfeeding practices among US mothers.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S50
EP - S55
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Shealy, Katherine R., Centers for Disease Control and Prevention, Division of Nutrition, Physical Activity, and Obesity, 4770 Buford Hwy, NE, Mail Stop K25, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-14322-004. Partial author list: First Author & Affiliation: Shealy, Katherine R.; Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Mothers; Trends. Minor Descriptor: Decision Making. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2008.
AB - Objectives: Although much has been published about breastfeeding rates, little is known about how breastfeeding is practiced in the United States. We describe the distributions and characteristics of practices related to common advice about breastfeeding during the infant's first year of life. Participants and Methods: Participants in the 2005-2007 Infant Feeding Practices Study II received monthly questionnaires during their infants' first year of life. Among breastfeeding respondents, we investigated patterns and trends in types of breastfeeding (supplementing with formula or not, and at the breast or not) and maternal report of infant feeding behaviors corresponding to common breastfeeding advice on frequency, duration, and intervals of feedings. Results: More than half of the breastfeeding mothers fed their infants nothing other than breast milk until 4 months of age. Formula supplementation declined from 42% at 1 month to 15% at 1 year; adding other foods/liquids increasingly surpassed supplementing with formula beginning at 5 months of age. Six percent of the mothers reported that the only breast milk the infant was fed was expressed, rather than at the breast. Frequency of breast milk feedings per day declined from 8 at 1 month to 3.5 at 1 year. Reported feeding durations of <2 0 minutes increased from 46% at 1 month to 88% at 1 year. Feeding from both breasts per feeding decreased 15% over the infant's first year (from 69% to 59%). Longest interfeeding intervals more than doubled over the year. Conclusions: Exclusive breastfeeding was common up to 4 but not to 6 months of age. Breastfeeding with only expressed milk was rare. Considerable variation existed in maternal report of practices that correspond to common breastfeeding advice. More research is needed to better understand how these variations relate to breastfeeding outcomes and the role of common breastfeeding advice in infant feeding decisions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breastfeeding practices
KW - US mothers
KW - infant feeding decisions
KW - 2008
KW - Breast Feeding
KW - Mothers
KW - Trends
KW - Decision Making
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315f
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-004&site=ehost-live&scope=site
UR - kshealy@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-005
AN - 2008-14322-005
AU - Fein, Sara B.
AU - Mandal, Bidisha
AU - Roe, Brian E.
T1 - Success of strategies for combining employment and breastfeeding.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S56
EP - S68
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Fein, Sara B., Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, HFS 020, College Park, MD, US, 20740
N1 - Accession Number: 2008-14322-005. Partial author list: First Author & Affiliation: Fein, Sara B.; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Child Care; Working Women. Classification: Childrearing & Child Care (2956). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Oct, 2008.
AB - Objective: Return to work is associated with diminished breastfeeding intensity and duration. Although more mothers breastfeed after returning to work now than earlier, research has not documented the strategies that mothers use for combining paid work and breastfeeding or their effect on breastfeeding outcomes. This study examined which strategies are associated with smaller decrements in breastfeeding intensity and longer durations. Participants and Methods: We analyzed 810 mothers from the Infant Feeding Practices Study II who worked and breastfed. We used regression and censored regression models to analyze 4 strategies that mothers used to combine these 2 activities: (1) feed directly from the breast only; (2) both pump and feed directly; (3) pump only; and (4) neither pump nor breastfeed during the work day. Outcomes were the difference in percentage of milk feeds that were breast milk between the month before and after return to work and duration of breastfeeding after return to work. Results: Forty-three percent of mothers pumped milk at work only; 32% fed the infant directly from the breast only. These 2 strategies, along with pumping and feeding directly, were statistically similar and superior to neither pumping nor breastfeeding during the work day for the outcome of change in breastfeeding intensity. For the outcome of breastfeeding duration, the 2 strategies that included directly feeding from the breast were associated with longer duration than pumping only, whereas the strategy of neither pumping nor breastfeeding during the work day was associated with the shortest duration. Conclusions: Feeding the infant from the breast during the work day is the most effective strategy for combining breastfeeding and work. Ways to enable direct feeding included on-site child care, telecommuting, keeping the infant at work, allowing the mother to leave work to go to the infant, and having the infant brought to the work site. Establishing ways for mothers to feed from the breast after return to work is important to meet US breastfeeding goals. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breastfeeding
KW - employment
KW - working mothers
KW - 2008
KW - Breast Feeding
KW - Child Care
KW - Working Women
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315g
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-005&site=ehost-live&scope=site
UR - sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-006
AN - 2008-14322-006
AU - Li, Ruowei
AU - Fein, Sara B.
AU - Chen, Jian
AU - Grummer-Strawn, Laurence M.
T1 - Why mothers stop breastfeeding: Mothers' self-reported reasons for stopping during the first year.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S69
EP - S76
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Li, Ruowei, Center for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition, Physical Activity, and Obesity, 4770 Buford Hwy, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-14322-006. Partial author list: First Author & Affiliation: Li, Ruowei; Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Center for Disease Control, Atlanta, GA, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Mothers; Weaning. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2008.
AB - Objectives: Our goal was to determine why women stop breastfeeding at various times during their infant's first year. Methods: We analyzed self-reported data from 1323 mothers who participated in the Infant Feeding Practice Study II. Mail questionnaires were sent to mothers ∼2, 3, 4, 5, 6, 7, 9.101/2, and 12 months after their child's birth, in which they were asked to rate the importance of 32 reasons for their decision to stop breastfeeding. We applied exploratory factorial analysis to extract meaningful constructs of mothers' responses to the 32 reasons. We then compared the percentages of mothers who indicated that each reason was important in their decision to stop breastfeeding among various weaning ages and used multiple logistic regression models to examine sociodemographic differences in the most frequently cited reasons for stopping breastfeeding. Results: The perception that their infant was not satisfied by breast milk alone was cited consistently as 1 of the top 3 reasons in the mothers' decision to stop breastfeeding regardless of weaning age (43.5%-55.6%) and was even more frequent among Hispanic mothers and mothers with annual household incomes of <350% of the federal poverty level. Mothers' concerns about lactation and nutrition issues were the most frequently cited reasons for stopping breastfeeding during the first 2 months. Starting from the third month, self-weaning reasons were increasingly cited as important, with the statements 'My baby began to bite' (31.7%), 'My baby lost interest in nursing or began to wean himself or herself' (47.3%), and 'Breast milk alone did not satisfy my baby' (43.5%) cited as the top 3 reasons at ≥9 months of age. Conclusions: Our findings about the major reasons why mothers stop breastfeeding at various times during their child's first year should be useful to health professionals when attempting to help mothers overcome breastfeeding barriers and to health officials attempting to devise targeted breastfeeding interventions on those issues prominent for each infant age. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breastfeeding duration & termination
KW - infant feeding practices
KW - 2008
KW - Breast Feeding
KW - Mothers
KW - Weaning
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315i
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-006&site=ehost-live&scope=site
UR - ri16@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-007
AN - 2008-14322-007
AU - Li, Ruowei
AU - Fein, Sara B.
AU - Grummer-Strawn, Laurence M.
T1 - Association of breastfeeding intensity and bottle-emptying behaviors at early infancy with infants' risk for excess weight at late infancy.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S77
EP - S84
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Li, Ruowei, Center for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition, Physical Activity and Obesity, 4770 Buford Hwy, Mail Stop K25, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-14322-007. Partial author list: First Author & Affiliation: Li, Ruowei; Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Center for Disease Control, Atlanta, GA, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bottle Feeding; Breast Feeding; Infant Development; Obesity; Risk Factors. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2008.
AB - Objective: Our goal was to test the hypothesis that infants who were breastfed more intensively during early infancy (≤6 months) will be less likely to have excess weight during late infancy (>6 months) and to examine the independent impact of infant-initiated bottle emptying and mothers' encouragement of bottle emptying on infants' risk for excess weight. Method: The sample consisted of 1896 mothers who participated in postpartum surveys of the Infant Feeding Practice Study II and who provided at least 1 weight measurement of their infants during the second half of infancy. We used multiple logistic regression models to assess the association between infants' risks for excess weight during the second half of infancy and 3 self-reported feeding practices during the first half of infancy after adjusting for a series of sociodemographic characteristics. The early feeding practices examined included the percentage of all milk feedings in which infants consumed breast milk (breastfeeding intensity), the frequency of bottle feedings in which infants initiated bottle emptying, and the frequency of bottle feedings in which mothers encouraged bottle emptying. Results: Infants fed with low (<20% of milk feeds being breast milk) and medium (20%-80%) breastfeeding intensity in the first half of infancy were at least 2 times more likely to have excess weight during the second half of infancy than those breastfed at high intensity (>80%). Infants who often emptied bottles in early infancy were 69% more likely than those who rarely emptied bottles to have excess weight during late infancy. However, mothers' encouragement of bottle emptying was negatively associated with their infants' risk for excess weight during the second half of infancy. Conclusions: Infants' risk for excess weight during late infancy was negatively associated with breastfeeding intensity but positively associated with infant-initiated bottle emptying during early infancy. These findings not only provide evidence for the potential risk of not breastfeeding or breastfeeding at a low intensity in development of childhood obesity, but they also suggest that infant-initiated bottle emptying may be an independent risk factor as well. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breastfeeding intensity
KW - bottle-emptying behaviors
KW - early infancy
KW - excess weight
KW - late infancy
KW - 2008
KW - Bottle Feeding
KW - Breast Feeding
KW - Infant Development
KW - Obesity
KW - Risk Factors
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315j
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-007&site=ehost-live&scope=site
UR - ril6@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-008
AN - 2008-14322-008
AU - Labiner-Wolfe, Judith
AU - Fein, Sara B.
AU - Shealy, Katherine R.
T1 - Infant formula–handling education and safety.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S85
EP - S90
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Labiner-Wolfe, Judith, Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, HFS 020, College Park, MD, US, 20740
N1 - Accession Number: 2008-14322-008. Partial author list: First Author & Affiliation: Labiner-Wolfe, Judith; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bottle Feeding; Knowledge Level; Mothers; Parent Training; Safety. Classification: Promotion & Maintenance of Health & Wellness (3365); Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2008.
AB - Objectives: Our goal was to assess the extent to which mothers learn about proper handling of infant formula from health professionals and package labels; mothers' beliefs about the likelihood of germs being in infant formula and the importance of following safe-use directions; whether they take measures while handling infant formula to prevent food borne illnesses and injury to their infants; and maternal characteristics associated with unsafe infant formula-handling practices. Participants and Methods: The study cohort consisted of mothers participating in the 2005-2007 Infant Feeding Practices Study II who fed their infant formula. We conducted frequency and multiple logistic regression analyses. Sample sizes for the analyses ranged from 860 to 1533. Results: The majority of formula-feeding mothers did not receive instruction on formula preparation (77%) or storage (73%) from a health professional. Thirty percent did not read some of the safe-use directions on the formula package label; an approximately equal percentage (38%) thought that both powdered (which is not sterile) and ready-to-feed (which is sterile) formula were unlikely to contain germs; and 85% believed that following safe-storage directions was very important. Among the mothers of the youngest infants analyzed, 55% did not always wash their hands with soap before preparing infant formula, 32% did not adequately wash bottle nipples between uses, 35% heated formula bottles in a microwave oven, and 6% did not always discard formula left standing for >2 hours. The prevalence of these unsafe practices was similar among mothers of older infants. No consistent pattern of maternal characteristics was associated with unsafe practices. Conclusions: Many mothers do not follow safe practices when preparing infant formula. Additional research is needed to understand why more mothers do not follow safe formula-handling recommendations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant formula-handling
KW - parent education
KW - safety practices
KW - 2008
KW - Bottle Feeding
KW - Knowledge Level
KW - Mothers
KW - Parent Training
KW - Safety
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315k
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-008&site=ehost-live&scope=site
UR - judy.labiner@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14322-009
AN - 2008-14322-009
AU - Fein, Sara B.
AU - Labiner-Wolfe, Judith
AU - Scanlon, Kelley S.
AU - Grummer-Strawn, Laurence M.
T1 - Selected complementary feeding practices and their association with maternal education.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/10//
VL - 122
IS - Suppl2
SP - S91
EP - S97
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Fein, Sara B., Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Pkwy, HFS 020, College Park, MD, US, 20740
N1 - Accession Number: 2008-14322-009. Partial author list: First Author & Affiliation: Fein, Sara B.; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, US. Release Date: 20090223. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Diets; Educational Attainment Level; Food; Mothers; Nutrition. Minor Descriptor: Breast Feeding. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2008.
AB - Objective: As infants transition from a milk-based diet to one that includes most food groups, the timing of the transition, how infants are fed, and the quality of their diet can have important health implications. Our objective is to describe these factors for US infants. Methods: We analyzed data from the Infant Feeding Practices Study II. Sample sizes varied for relevant questions from ∼1600 to ∼2400. We analyzed the prevalence of 14 feeding practices and their association with the mothers' education and also examined participants' use of commercial baby foods. Results: Approximately 21% of the mothers introduced solid foods before 4 months; 7% introduced solids after 6 months. Twenty-nine percent of the mothers introduced >3 new foods per week to infants aged 5 to 10 months. Approximately 20% of the mothers fed juice before 6 months, fed cow's milk before 12 months, and fed infants <5 times per day after 5 months. Fourteen percent of the mothers chewed food for their infant. Approximately 15% of the mothers fed <1 serving daily of either a fruit or vegetable to infants aged ≥9 months, half added salt to their infant's food, and more than one third who added salt used noniodized salt. Approximately 20% fed reduced-fat cow's milk at 1 year. Almost half of the 10-month-old infants had eaten restaurant food in a restaurant in the previous week, 22% had eaten carry-out food, and 28% had eaten either type of restaurant food ≥2 times. The prevalence of 8 of the 14 unhealthful infant feeding practices we examined was inversely associated with maternal education. Conclusions: Nutrition and feeding guidance should be especially targeted to mothers with a high school education or less. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - selected complementary feeding practices
KW - maternal educational attainment level
KW - nutrition
KW - feeding guidance
KW - health implications
KW - milk-based diet
KW - 2008
KW - Diets
KW - Educational Attainment Level
KW - Food
KW - Mothers
KW - Nutrition
KW - Breast Feeding
KW - 2008
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, National Institutes of Health, Maternal and Child Health Bureau,Office of Women's Health, US. Recipients: No recipient indicated
DO - 10.1542/peds.2008-1315l
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14322-009&site=ehost-live&scope=site
UR - sara.fein@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-13704-006
AN - 2008-13704-006
AU - van de Looij-Jansen, Petra M.
AU - de Wilde, Erik Jan
T1 - Comparison of web-based versus paper-and-pencil self-administered questionnaire: Effects on health indicators in Dutch adolescents.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2008/10//
VL - 43
IS - 5, part 1
SP - 1708
EP - 1721
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - van de Looij-Jansen, Petra M., Youth Department, Municipal Public Health Service for the Rotterdam Area, PO Box 70032, 3000 LP, Rotterdam, Netherlands
N1 - Accession Number: 2008-13704-006. PMID: 18479404 Partial author list: First Author & Affiliation: van de Looij-Jansen, Petra M.; Youth Department, Municipal Public Health Service for the Rotterdam Area, Rotterdam, Netherlands. Other Publishers: Blackwell Publishing. Release Date: 20090914. Correction Date: 20151019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Behavior; Test Administration; Testing Methods. Minor Descriptor: Data Collection; Internet; Questionnaires; Responses. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Child Health Questionnaire; Rosenberg Self-Esteem Scale DOI: 10.1037/t01038-000; Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Internet; Web Sites Internet. References Available: Y. Page Count: 14. Issue Publication Date: Oct, 2008.
AB - Objective: The aim of this study is to investigate differences in responses related to (mental) health and behavior between two methods of data collection: web-based (web) and paper-and-pencil (p&p). Study Design: Within each participating school all third-grade classes (mainly 14–15-year-old pupils) were randomly assigned to either the Internet condition (n = 271) or the paper-and-pencil condition (n = 261). Principal Findings: Significant but small differences were found for the strengths and difficulties subscales 'emotional symptoms' (p&p > web) and 'prosocial behavior' (p&p > web), and carrying a weapon (web > p&p). Perceived level of privacy and confidentiality did not differ between the two modes. Conclusions: The findings suggest that in a controlled school setting, web-based administration of health indicators yields almost the same results as paper-and-pencil administration. To generalize these findings, we recommend repeated studies in other populations and settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - web-based vs paper & pencil questionnaire
KW - response differences
KW - health indicators
KW - health behavior
KW - data collection
KW - 2008
KW - Health Behavior
KW - Test Administration
KW - Testing Methods
KW - Data Collection
KW - Internet
KW - Questionnaires
KW - Responses
KW - 2008
DO - 10.1111/j.1475-6773.2008.00860.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13704-006&site=ehost-live&scope=site
UR - vandelooijp@ggd.rotterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14014-016
AN - 2008-14014-016
AU - Kogan, Michael D.
AU - Singh, Gopal K.
AU - Dee, Deborah L.
AU - Belanoff, Candice
AU - Grummer-Strawn, Laurence M.
T1 - Multivariate analysis of state variation in breastfeeding rates in the United States.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/10//
VL - 98
IS - 10
SP - 1872
EP - 1880
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Kogan, Michael D., Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2008-14014-016. PMID: 18703441 Partial author list: First Author & Affiliation: Kogan, Michael D.; Health Resources and Services Administration's, Maternal and Child Health Bureau, Rockville, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Breast Feeding; Demographic Characteristics; Psychosocial Factors. Classification: Childrearing & Child Care (2956). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Oct, 2008. Publication History: Accepted Date: Feb 29, 2008.
AB - Objectives: We sought to determine the impact of sociodemographic and behavioral factors and state legislation on breastfeeding initiation (child ever fed breastmilk) and duration. Methods: We used data from a nationally representative study of children aged 6 to 71 months (N = 33 121); we calculated unadjusted and adjusted state estimates for breastfeeding initiation and duration. We used logistic regression models to examine factors associated with never breastfeeding or breastfeeding less than 6 months. We conducted a multilevel analysis of state legislation's role. Results: There were wide state variations in breastfeeding initiation and duration. The western and northwestern states had the highest rates. Covariate adjustment accounted for 25% to 30% of the disparity. Multivariate analysis showed that the adjusted odds of not being breastfed were 2.5- to 5.15-times greater in southern states compared with Oregon (reference). Children in states without breastfeeding legislation had higher odds of not being breastfed. Conclusions: Sociodemographic and maternal factors do not account for most breastfeeding rate variation. The association with breastfeeding legislation should be explored and may reflect cultural norms. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - breastfeeding rates
KW - sociodemographic factors
KW - behavioral factors
KW - 2008
KW - Breast Feeding
KW - Demographic Characteristics
KW - Psychosocial Factors
KW - 2008
DO - 10.2105/AJPH.2007.127118
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14014-016&site=ehost-live&scope=site
UR - ORCID: 0000-0002-2491-7548
UR -
UR - mkogan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-13593-003
AN - 2008-13593-003
AU - Marum, Elizabeth
AU - Morgan, Gwendolyn
AU - Hightower, Allen
AU - Ngare, Carol
AU - Taegtmeyer, Miriam
T1 - Using mass media campaigns to promote voluntary counseling and HIV-testing services in Kenya.
JF - AIDS
JO - AIDS
JA - AIDS
Y1 - 2008/10//
VL - 22
IS - 15
SP - 2019
EP - 2024
CY - US
PB - Lippincott Williams & Wilkins
SN - 0269-9370
SN - 1473-5571
AD - Marum, Elizabeth, US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, 1600 Clifton Road, MS E-04, Atlanta, GA, US, 30333
N1 - Accession Number: 2008-13593-003. PMID: 18784464 Partial author list: First Author & Affiliation: Marum, Elizabeth; US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, GA, US. Release Date: 20090810. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; HIV Testing; Mass Media; Public Health Services. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: Kenya. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2008.
AB - Background: Kenya, a country with high HIV prevalence, has seen a rapid scale-up of voluntary counseling and HIV-testing (VCT) services from three sites in 2000 to 585 by June 2005. From 2002 onwards, services were promoted by a four-phase professionally designed mass media campaign. Objective: To assess the impact of a mass media campaign on VCT services. Design: Observational data from client records. Methods: VCT client data from 131 voluntary counseling and testing sites were included. Descriptive statistics and Poisson regression were used to assess the impact of campaign phases. Results: Client records (381 160) from 131 sites were analyzed. A linear increase in new sites and an exponential increase in client utilization were observed. Regression analysis revealed that the first phase of the campaign increased attendance by 28.5% (95% confidence interval = 15.9, 42.5%) and the fourth by 42.5% (95% confidence interval = 28.4, 64.1%). These two phases, which directly mentioned HIV, had more impact on utilization than the second and third phases, which did not have a significant effect. Conclusion: The Kenyan experience suggests that a professional, intensive mass media campaign is likely to contribute to increases in utilization of testing. Expansion of programs for counseling and HIV testing in developing countries is likely to be facilitated by mass media promotion of these services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mass media campaigns
KW - voluntary counseling
KW - HIV testing services
KW - 2008
KW - Counseling
KW - HIV Testing
KW - Mass Media
KW - Public Health Services
KW - 2008
U1 - Sponsor: Government of Kenya, Kenya. Recipients: No recipient indicated
U1 - Sponsor: President’s Emergency Plan for AIDS Relief (PEPFAR). Recipients: No recipient indicated
U1 - Sponsor: Global Fund for AIDS, Tuberculosis and Malaria. Recipients: No recipient indicated
U1 - Sponsor: World Bank. Recipients: No recipient indicated
U1 - Sponsor: UK Department for International Development, United Kingdom. Recipients: No recipient indicated
U1 - Sponsor: Japanese International Cooperation Agency, Japan. Recipients: No recipient indicated
U1 - Sponsor: US Department of Health and Human Services, Centers for Disease Control and Prevention, Global AIDS Program, US. Recipients: No recipient indicated
U1 - Sponsor: US Agency for International Development, US. Recipients: No recipient indicated
DO - 10.1097/QAD.0b013e3283104066
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-13593-003&site=ehost-live&scope=site
UR - emarum@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15903-005
AN - 2008-15903-005
AU - Nishi, Akinori
AU - Kuroiwa, Mahomi
AU - Miller, Diane B.
AU - O'Callaghan, James P.
AU - Bateup, Helen S.
AU - Shuto, Takahide
AU - Sotogaku, Naoki
AU - Fukuda, Takaichi
AU - Heintz, Nathaniel
AU - Greengard, Paul
AU - Snyder, Gretchen L.
T1 - Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.
JF - The Journal of Neuroscience
JO - The Journal of Neuroscience
JA - J Neurosci
Y1 - 2008/10//
VL - 28
IS - 42
SP - 10460
EP - 10471
CY - US
PB - Society for Neuroscience
SN - 0270-6474
SN - 1529-2401
AD - Nishi, Akinori, Department of Pharmacology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, Japan, 830-0011
N1 - Accession Number: 2008-15903-005. PMID: 18923023 Partial author list: First Author & Affiliation: Nishi, Akinori; Department of Pharmacology, Kurume University School of Medicine, Fukuoka, Japan. Release Date: 20090323. Correction Date: 20170209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Nishi, Akinori. Major Descriptor: Kinases; Neurotransmission; Phosphorylases; Proteins; Striatum. Minor Descriptor: Cognitive Processes; Dopamine; Neural Receptors; Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Oct, 2008.
AB - Phosphodiesterase (PDE) is a critical regulator of cAMP/protein kinase A (PKA) signaling in cells. Multiple PDEs with different substrate specificities and subcellular localization are expressed in neurons. Dopamine plays a central role in the regulation of motor and cognitive functions. The effect of dopamine is largely mediated through the cAMP/PKA signaling cascade, and therefore controlled by PDE activity. We used in vitro and in vivo biochemical techniques to dissect the roles of PDE4 and PDE10A in dopaminergic neurotransmission in mouse striatum by monitoring the ability of inhibitors to regulate phosphorylation of presynaptic [e.g., tyrosine hydroxylase (TH)] and postsynaptic [e.g., dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa (DARPP-32)] PKA substrates. The PDE4 inhibitor, rolipram, induced a large increase in TH Ser40 phosphorylation at dopaminergic terminals that was associated with a commensurate increase in dopamine synthesis and turnover in striatum in vivo. Rolipram induced a small increase in DARPP-32 Thr34 phosphorylation preferentially in striatopallidal neurons by activating adenosine A2A receptor signaling in striatum. In contrast, the PDE10A inhibitor, papaverine, had no effect on TH phosphorylation or dopamine turnover, but instead robustly increased DARPP-32 Thr34 and GluR1 Ser845 phosphorylation in striatal neurons. Inhibition of PDE10A by papaverine activated cAMP/PKA signaling in both striatonigral and striatopallidal neurons, resulting in potentiation of dopamine D₁ receptor signaling and inhibition of dopamine D₂ receptor signaling. These biochemical results are supported by immunohistochemical data demonstrating differential localization of PDE10A and PDE4 in striatum. These data underscore the importance of individual brain-enriched cyclic-nucleotide PDE isoforms as therapeutic targets for neuropsychiatric and neurodegenerative disorders affecting dopamine neurotransmission. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - phosphodiesterase
KW - striatum
KW - protein kinase
KW - mice
KW - cognitive functions
KW - dopamine
KW - neurotransmission
KW - neural receptors
KW - phosphorylation
KW - 2008
KW - Kinases
KW - Neurotransmission
KW - Phosphorylases
KW - Proteins
KW - Striatum
KW - Cognitive Processes
KW - Dopamine
KW - Neural Receptors
KW - Rats
KW - 2008
U1 - Sponsor: Japan Society for the Promotion of Science, Japan. Grant: 18300128. Other Details: Grant-in-Aid for Scientific Research. Recipients: Nishi, Akinori
U1 - Sponsor: US Public Health Service, US. Grant: MH40899; DA10044. Recipients: Greengard, Paul
U1 - Sponsor: US Public Health Service, US. Grant: MH067488. Recipients: Snyder, Gretchen L.
U1 - Sponsor: Picower Foundation. Recipients: Greengard, Paul
U1 - Sponsor: Michael Stern Parkinson’s Research Foundation. Recipients: Greengard, Paul
U1 - Sponsor: US Department of Defense, US. Grant: DAMD17-02-1-00705. Recipients: Greengard, Paul
U1 - Sponsor: US Department of Defense, US. Grant: DAMD17-03-1-0396; W81XWH-04-2-0009. Recipients: Snyder, Gretchen L.
DO - 10.1523/JNEUROSCI.2518-08.2008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15903-005&site=ehost-live&scope=site
UR - nishia@med.kurume-u.ac.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Fraser, Irene
AU - Encinosa, William
AU - Glied, Sherry
T1 - Improving Efficiency and Value in Health Care: Introduction.
JO - Health Services Research
JF - Health Services Research
Y1 - 2008/10/02/
VL - 43
IS - 5p2
M3 - Article
SP - 1781
EP - 1786
PB - Wiley-Blackwell
SN - 00179124
AB - The article discusses various reports published within the issue, including one by John Olson, James Belohlav, Lori Cook and Julie Hays on common quality improvement programs among hospitals, one by Anita Tucker, Sara Singer, Jennifer Hayes and Alyson Falwell on hospital work systems, and one by Vivian Valdmanis, Michael Rosko and Ryan Mutter on inefficiency in hospitals.
KW - MEDICAL care
KW - HOSPITALS
N1 - Accession Number: 34375800; Fraser, Irene 1; Email Address: Irene.fraser@ahrq.hhs.gov Encinosa, William 2 Glied, Sherry 3; Affiliation: 1: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD 3: Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, NY; Source Info: Oct2008, Vol. 43 Issue 5p2, p1781; Subject Term: MEDICAL care; Subject Term: HOSPITALS; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 6p; Document Type: Article
L3 - 10.1111/j.1475-6773.2008.00904.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34375800&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valdmanis, Vivian G.
AU - Rosko, Michael D.
AU - Mutter, Ryan L.
T1 - Hospital Quality, Efficiency, and Input Slack Differentials.
JO - Health Services Research
JF - Health Services Research
Y1 - 2008/10/02/
VL - 43
IS - 5p2
M3 - Article
SP - 1830
EP - 1848
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To use an advance in data envelopment analysis (DEA) called congestion analysis to assess the trade-offs between quality and efficiency in U.S. hospitals. Study Setting. Urban U.S. hospitals in 34 states operating in 2004. Study Design and Data Collection. Input and output data from 1,377 urban hospitals were taken from the American Hospital Association Annual Survey and the Medicare Cost Reports. Nurse-sensitive measures of quality came from the application of the Patient Safety Indicator (PSI) module of the Agency for Healthcare Research and Quality (AHRQ) Quality Indicator software to State Inpatient Databases (SID) provided by the Healthcare Cost and Utilization Project (HCUP). Data Analysis. In the first step of the study, hospitals' relative output-based efficiency was determined in order to obtain a measure of congestion (i.e., the productivity loss due to the occurrence of patient safety events). The outputs were adjusted to account for this productivity loss, and a second DEA was performed to obtain input slack values. Differences in slack values between unadjusted and adjusted outputs were used to measure either relative inefficiency or a need for quality improvement. Principal Findings. Overall, the hospitals in our sample could increase the total amount of outputs produced by an average of 26 percent by eliminating inefficiency. About 3 percent of this inefficiency can be attributed to congestion. Analysis of subsamples showed that teaching hospitals experienced no congestion loss. We found that quality of care could be improved by increasing the number of labor inputs in low-quality hospitals, whereas high-quality hospitals tended to have slack on personnel. Conclusions. Results suggest that reallocation of resources could increase the relative quality among hospitals in our sample. Further, higher quality in some dimensions of care need not be achieved as a result of higher costs or through reduced access to health care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - QUALITY
KW - HOSPITALS
KW - INDUSTRIAL efficiency
KW - DATA envelopment analysis
KW - congestion
KW - data envelopment analysis
KW - Hospital efficiency
KW - nurse-sensitive outcomes
KW - patient safety
N1 - Accession Number: 34375801; Valdmanis, Vivian G. 1 Rosko, Michael D. 2 Mutter, Ryan L. 3; Email Address: rmutter@ahrq.gov; Affiliation: 1: Department of Health Policy & Public Health, University of the Sciences in Philadelphia, PA and 2: Graduate Program in Health and Medical Services Administration, School of Business Administration, One University Place, Widener University, Chester, PA 3: Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, 540 Gaither Road, Rockville, MD 20850,; Source Info: Oct2008, Vol. 43 Issue 5p2, p1830; Subject Term: MEDICAL care; Subject Term: QUALITY; Subject Term: HOSPITALS; Subject Term: INDUSTRIAL efficiency; Subject Term: DATA envelopment analysis; Author-Supplied Keyword: congestion; Author-Supplied Keyword: data envelopment analysis; Author-Supplied Keyword: Hospital efficiency; Author-Supplied Keyword: nurse-sensitive outcomes; Author-Supplied Keyword: patient safety; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 19p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2008.00893.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fein, Sara B.
AU - Labiner-Wolfe, Judith
AU - Shealy, Katherine R.
AU - Rouwei Li
AU - Jian Chen
AU - Grummer-Strawn, Laurence M.
T1 - Infant Feeding Practices Study II: Study Methods.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/10/02/Oct2008 Supplement 2
VL - 122
M3 - Article
SP - S28
EP - S35
SN - 00314005
AB - OBJECTIVE. Our goal is to describe the methods used in the Infant Feeding Practices Study II (IFPS 11), a study of infant feeding and care practices throughout the first year of life. Survey topics included breastfeeding, formula and complementary feeding, infant health, breast-pump use, food allergies, sleeping arrangements, mother's employment, and child care arrangements. In addition, mothers' dietary intake was measured prenatally and postnatally. PARTICIPANTS AND METHODS. The IFPS II sample was drawn from a nationally distributed consumer opinion panel of 500 000 households. All questionnaires were administered by mail, 1 prenatally and 10 postpartum. Qualifying criteria were used to achieve the sample goals of mothers of healthy term and late preterm singleton infants. In addition to the questionnaires about the infants, women were sent a diet-assessment questionnaire prenatally and at ∼4 months after delivery; this questionnaire was also sent to members of a comparison group who were neither pregnant nor postpartum. RESULTS. A sample of 4902 pregnant women began the study, and ∼2000 continued through their infant's first year. Response rates ranged from 63% to 87% for the different questionnaires. Compared with adult mothers of singletons from the nationally representative sample of the National Survey of Family Growth, IFPS II participants had a higher mean education level; were older; were more likely to be middle income, white, and employed; were less likely to smoke; and had fewer other children. Compared with women who participated in the National Immunization Survey who gave birth in 2004, IFPS II mothers were more likely to breastfeed and to breastfeed longer. CONCLUSIONS. The IFPS II provides a valuable database because of its large sample size, the frequency of its questionnaires, and its wide coverage of issues salient to infant feeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BOTTLE feeding
KW - BREASTFEEDING (Humans)
KW - INFANT nutrition
KW - INFANTS -- Care
KW - CHILD care
KW - PREGNANT women
KW - PEDIATRICS
KW - CHILDREN -- Health
KW - SURVEYS
KW - bottle feeding
KW - breastfeeding
KW - infant care
KW - infant nutrition
KW - physiology
N1 - Accession Number: 34659879; Fein, Sara B. 1 Labiner-Wolfe, Judith 1 Shealy, Katherine R. Rouwei Li Jian Chen Grummer-Strawn, Laurence M.; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Oct2008 Supplement 2, Vol. 122, pS28; Subject Term: BOTTLE feeding; Subject Term: BREASTFEEDING (Humans); Subject Term: INFANT nutrition; Subject Term: INFANTS -- Care; Subject Term: CHILD care; Subject Term: PREGNANT women; Subject Term: PEDIATRICS; Subject Term: CHILDREN -- Health; Subject Term: SURVEYS; Author-Supplied Keyword: bottle feeding; Author-Supplied Keyword: breastfeeding; Author-Supplied Keyword: infant care; Author-Supplied Keyword: infant nutrition; Author-Supplied Keyword: physiology; Number of Pages: 8p; Document Type: Article
L3 - 10.1542/peds.2008-1315c
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grummer-Strawn, Laurence M.
AU - Scanlon, Kelley S.
AU - Fein, Sara B.
T1 - Infant Feeding and Feeding Transitions During the First Year of Life.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/10/02/Oct2008 Supplement 2
VL - 122
M3 - Article
SP - S36
EP - S42
SN - 00314005
AB - OBJECTIVE. Infancy is a time of rapid transition from a diet of virtually nothing but milk (either breast milk or infant formula) to a varied diet from nearly all food groups being consumed on a daily basis by most infants. Despite various recommendations about infant feeding, little is known about actual patterns of feeding among US infants. This article documents transitions in infant feeding patterns across the first year of life and determinants of key aspects of infant feeding. METHODS. Using data from the Infant Feeding Practices Study II, we analyzed responses to a 7-day food-recall chart that was administered every month. The sample size declined from 2907 at birth to 1782 at 12 months of age. RESULTS. Although 83% of survey respondents initiated breastfeeding, the percentage who breastfed declined rapidly to 50% at 6 months and to 24% at 12 months. Many of the women who breastfed also fed their infants formula; 52% reported that their infants received formula while in the hospital. At 4 months, 40% of the infants had consumed infant cereal, 17% had consumed fruit or vegetable products, and <1% had consumed meat. Compared with infants who were not fed solid foods at 4 months, those who were fed solid foods were more likely to have discontinued breastfeeding at 6 months (70% vs 34%) and to have been fed fatty or sugary foods at 12 months (75% vs 62%). CONCLUSIONS. Supplementing breast milk with infant formula while infants were still in the hospital was very common. Despite recommendations that complementary foods not be introduced to infants aged 4 months or younger, almost half of the infants in this study had consumed solid foods by the age of 4 months. This early introduction of complementary foods was associated with unhealthful subsequent feeding behaviors. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT nutrition
KW - INFANTS -- Care
KW - BREASTFEEDING (Humans)
KW - INFANT formulas
KW - BOTTLE feeding
KW - LACTATION
KW - INFANTS -- Physiology
KW - PEDIATRICS
KW - UNITED States
KW - breast milk
KW - infant feeding
KW - solid food introduction
N1 - Accession Number: 34659880; Grummer-Strawn, Laurence M. Scanlon, Kelley S. Fein, Sara B. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Oct2008 Supplement 2, Vol. 122, pS36; Subject Term: INFANT nutrition; Subject Term: INFANTS -- Care; Subject Term: BREASTFEEDING (Humans); Subject Term: INFANT formulas; Subject Term: BOTTLE feeding; Subject Term: LACTATION; Subject Term: INFANTS -- Physiology; Subject Term: PEDIATRICS; Subject Term: UNITED States; Author-Supplied Keyword: breast milk; Author-Supplied Keyword: infant feeding; Author-Supplied Keyword: solid food introduction; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 7p; Illustrations: 2 Charts, 1 Map; Document Type: Article
L3 - 10.1542/peds.2008-1315d
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Labiner-Wolfe, Judith
AU - Fein, Sara B.
AU - Shealy, Katherine R.
AU - Cunlin Wang
T1 - Prevalence of Breast Milk Expression and Associated Factors.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/10/02/Oct2008 Supplement 2
VL - 122
M3 - Article
SP - S63
EP - S68
SN - 00314005
AB - OBJECTIVES. Our goal was to describe the prevalence of any, occasional, and regular breast milk expression, mothers' reasons for expressing their milk, and sociodemographic factors associated with breast milk expression. PARTICIPANTS AND METHODS. Breastfeeding mothers participating in the 2005-2007 Infant Feeding Practices Study II formed the cohort for these analyses, which were conducted among those with infants in 3 age groups: 1.5 to 4.5 months (n = 1564); >4.5 to 6.5 months (n = 1128); and >6.5 to 9.5 months (n = 914). For the analyses we used frequency and stepwise multiple logistic regression procedures. RESULTS. Eighty-five percent of breastfeeding mothers of infants in the youngest age group had successfully expressed milk at some time since their infant was born. When asked only about the previous 2-week period, 68% of the breastfeeding mothers of infants in this youngest age group had expressed milk, with 43% having done so occasionally and 25% on a regular schedule. Approximately one quarter of breastfeeding mothers of infants in the 2 older infant age groups also expressed milk on a regular schedule. The percentage of mothers expressing milk decreased with increasing infant age. Mothers expressed milk for various reasons. The most frequently cited reason was to get breast milk for someone else to feed their infant. In all 3 age groups, reporting any breast milk expression, compared with none, was positively associated with maternal employment, higher income, lack of previous breastfeeding experience, and living in the Midwest versus the West. In all 3 age groups, expressing milk on a regular schedule, compared with occasionally, was positively associated with maternal employment and the use of an electric versus manual breast pump. CONCLUSIONS. Breast milk expression is a very common practice. It is associated most strongly with maternal employment, a recognized barrier to breastfeeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREASTFEEDING (Humans)
KW - BREAST milk
KW - INFANT nutrition
KW - MOTHER & infant
KW - INFANTS -- Care
KW - PEDIATRICS
KW - breast milk
KW - breastfeeding
KW - medical device
N1 - Accession Number: 34659884; Labiner-Wolfe, Judith 1; Email Address: judy.Iabiner@fda.hhs.gov Fein, Sara B. Shealy, Katherine R. Cunlin Wang; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Oct2008 Supplement 2, Vol. 122, pS63; Subject Term: BREASTFEEDING (Humans); Subject Term: BREAST milk; Subject Term: INFANT nutrition; Subject Term: MOTHER & infant; Subject Term: INFANTS -- Care; Subject Term: PEDIATRICS; Author-Supplied Keyword: breast milk; Author-Supplied Keyword: breastfeeding; Author-Supplied Keyword: medical device; Number of Pages: 6p; Document Type: Article
L3 - 10.1542/peds.2008-1315h
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34659884&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ruowei Li
AU - Fein, Sara B.
AU - Jian Chen
AU - Grummer-Strawn, Laurence M.
T1 - Why Mothers Stop Breastfeeding: Mothers' Self-reported Reasons for Stopping During the First Year.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/10/02/Oct2008 Supplement 2
VL - 122
M3 - Article
SP - S69
EP - S76
SN - 00314005
AB - OBJECTIVES. Our goal was to determine why women stop breastfeeding at various times during their infant's first year. METHODS. We analyzed self-reported data from 1323 mothers who participated in the Infant Feeding Practice Study II. Mail questionnaires were sent to mothers ∼2, 3, 4, 5, 6, 7, 9, 10½, and 12 months after their child's birth, in which they were asked to rate the importance of 32 reasons for their decision to stop breastfeeding. We applied exploratory factorial analysis to extract meaningful constructs of mothers' responses to the 32 reasons. We then compared the percentages of mothers who indicated that each reason was important in their decision to stop breastfeeding among various weaning ages and used multiple logistic regression models to examine sociodemographic differences in the most frequently cited reasons for stopping breastfeeding. RESULTS. The perception that their infant was not satisfied by breast milk alone was cited consistently as 1 of the top 3 reasons in the mothers' decision to stop breastfeeding regardless of weaning age (43.5%-55.6%) and was even more frequent among Hispanic mothers and mothers with annual household incomes of <3 50% of the federal poverty level. Mothers' concerns about lactation and nutrition issues were the most frequently cited reasons for stopping breastfeeding during the first 2 months. Starting from the third month, self-weaning reasons were increasingly cited as important, with the statements "My baby began to bite" (31.7%), "My baby lost interest in nursing or began to wean himself or herself" (47.3%), and "Breast milk alone did not satisfy my baby" (43.5%) cited as the top 3 reasons at ≥9 months of age. CONCLUSIONS. Our findings about the major reasons why mothers stop breastfeeding at various times during their child's first year should be useful to health professionals when attempting to help mothers overcome breastfeeding barriers and to health officials attempting to devise targeted breastfeeding interventions on those issues prominent for each infant age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREASTFEEDING (Humans)
KW - MOTHER & infant
KW - INFANT nutrition
KW - WEANING of infants
KW - LACTATION
KW - BREAST milk
KW - INFANTS -- Care
KW - PEDIATRICS
KW - breastfeeding
KW - infant
KW - lactation
KW - weaning
N1 - Accession Number: 34659885; Ruowei Li Fein, Sara B. 1 Jian Chen Grummer-Strawn, Laurence M.; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Oct2008 Supplement 2, Vol. 122, pS69; Subject Term: BREASTFEEDING (Humans); Subject Term: MOTHER & infant; Subject Term: INFANT nutrition; Subject Term: WEANING of infants; Subject Term: LACTATION; Subject Term: BREAST milk; Subject Term: INFANTS -- Care; Subject Term: PEDIATRICS; Author-Supplied Keyword: breastfeeding; Author-Supplied Keyword: infant; Author-Supplied Keyword: lactation; Author-Supplied Keyword: weaning; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1542/peds.2008-1315i
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Luccioli, Stefano
AU - Ross, Marianne
AU - Labiner-Wolfe, Judith
AU - Fein, Sara B.
T1 - Maternally Reported Food Allergies and Other Food-Related Health Problems in Infants: Characteristics and Associated Factors.
JO - Pediatrics
JF - Pediatrics
Y1 - 2008/10/02/Oct2008 Supplement 2
VL - 122
M3 - Article
SP - S105
EP - S112
SN - 00314005
AB - OBJECTIVE. Our goal was to identify the frequency, demographics, and diagnostic characteristics associated with maternally reported food allergies and other food-related health problems among infants aged ≤1 year. METHODS. We analyzed data from the 2005-2007 Infant Feeding Practices Study II, a longitudinal survey of 2441 US mothers of healthy singletons from pregnancy through their infant's first year. Doctor diagnosis and symptoms-based criteria were used to identify a probable-food-allergic group from maternal reports of infant health problems with food. RESULTS. More than one fifth of the 2441 mothers reported that their infant had a food-related problem; 6% (n = 143) had a probable food allergy, and 15% (n = 359) had other food-related problems. Forty percent of the infants with a food-related health problem were evaluated by a doctor. Gastrointestinal symptoms were more commonly reported in early infancy compared with skin-related symptoms, which were reported in later infancy, and 27% received medical treatment for the symptoms. Characteristics associated with increased incidence of probable food allergy included family histories of food allergy and type 1 diabetes, gestational diabetes, living in rural or urban areas, being black, and being male. Among all infants with a food-related health problem, the majority experienced their first problem by 6 months of age. Foods recognized to be major allergens were most commonly reported as the source of an allergy. CONCLUSIONS. Food-related problems occurred at a high frequency in the first year of life. A better understanding of the demographics, family history, disease manifestations, and diagnoses may provide insight into public health efforts to minimize or prevent food allergies in infancy and to help differentiate food-allergic problems from nonallergic food problems in this age group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD allergy in infants
KW - ALLERGY in infants
KW - INFANT nutrition
KW - INFANTS -- Care
KW - MOTHER & infant
KW - PEDIATRICS
KW - diet
KW - food allergy
KW - food hypersensitivity
KW - food intolerance
KW - infants
N1 - Accession Number: 34659890; Luccioli, Stefano 1 Ross, Marianne 1 Labiner-Wolfe, Judith 1 Fein, Sara B. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Oct2008 Supplement 2, Vol. 122, pS105; Subject Term: FOOD allergy in infants; Subject Term: ALLERGY in infants; Subject Term: INFANT nutrition; Subject Term: INFANTS -- Care; Subject Term: MOTHER & infant; Subject Term: PEDIATRICS; Author-Supplied Keyword: diet; Author-Supplied Keyword: food allergy; Author-Supplied Keyword: food hypersensitivity; Author-Supplied Keyword: food intolerance; Author-Supplied Keyword: infants; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1542/peds.2008-1315n
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105687831
T1 - Infant feeding and care practices in the United States: results from the Infant Feeding Practices Study II.
AU - Fein SB
AU - Grummer-Strawn LM
AU - Raju TNK
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687831. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Breast Feeding -- Evaluation
KW - Child Care -- Methods
KW - Infant Feeding -- Trends -- United States
KW - Child Health
KW - Infant
KW - Infant Nutrition
KW - Patient Compliance
KW - United States
KW - United States Department of Health and Human Services
KW - United States Food and Drug Administration
SP - S25
EP - 7
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; sara.fein@fda.hhs.gov
U2 - PMID: 18829827.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687833
T1 - Infant Feeding Practices Study II: study methods.
AU - Fein SB
AU - Labiner-Wolfe J
AU - Shealy KR
AU - Li R
AU - Chen J
AU - Grummer-Strawn LM
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687833. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Instrumentation: Dietary History Questionnaire (DHQ). Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Infant Feeding -- Psychosocial Factors
KW - Infant Nutrition -- Evaluation
KW - Nutritional Assessment -- Methods
KW - Adult
KW - Bottle Feeding -- Evaluation
KW - Breast Feeding -- Evaluation
KW - Child
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Infant
KW - Infant Feeding, Supplemental -- Evaluation
KW - Maternal Attitudes
KW - Pregnancy
KW - Prospective Studies
KW - Public Health Nutrition
KW - Questionnaires
KW - Human
SP - S28
EP - 35
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE. Our goal is to describe the methods used in the Infant Feeding Practices Study II (IFPS II), a study of infant feeding and care practices throughout the first year of life. Survey topics included breastfeeding, formula and complementary feeding, infant health, breast-pump use, food allergies, sleeping arrangements, mother's employment, and child care arrangements. In addition, mothers' dietary intake was measured prenatally and postnatally.PARTICIPANTS AND METHODS. The IFPS II sample was drawn from a nationally distributed consumer opinion panel of 500000 households. All questionnaires were administered by mail, 1 prenatally and 10 postpartum. Qualifying criteria were used to achieve the sample goals of mothers of healthy term and late preterm singleton infants. In addition to the questionnaires about the infants, women were sent a diet-assessment questionnaire prenatally and at 4 months after delivery; this questionnaire was also sent to members of a comparison group who were neither pregnant nor postpartum.RESULTS. A sample of 4902 pregnant women began the study, and 2000 continued through their infant's first year. Response rates ranged from 63% to 87% for the different questionnaires. Compared with adult mothers of singletons from the nationally representative sample of the National Survey of Family Growth, IFPS II participants had a higher mean education level; were older; were more likely to be middle income, white, and employed; were less likely to smoke; and had fewer other children. Compared with women who participated in the National Immunization Survey who gave birth in 2004, IFPS II mothers were more likely to breastfeed and to breastfeed longer.CONCLUSIONS. The IFPS II provides a valuable database because of its large sample size, the frequency of its questionnaires, and its wide coverage of issues salient to infant feeding.
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; sara.fein@fda.hhs.gov
U2 - PMID: 18829828.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687835
T1 - Success of strategies for combining employment and breastfeeding.
AU - Fein SB
AU - Mandal B
AU - Roe BE
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687835. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Attitude to Breast Feeding
KW - Breast Feeding -- Evaluation -- United States
KW - Employment
KW - Maternal Attitudes
KW - Adult
KW - Analysis of Variance
KW - Breast Feeding -- Psychosocial Factors
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Infant
KW - Infant Formula
KW - Regression
KW - United States
KW - Human
SP - S56
EP - 62
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE. Return to work is associated with diminished breastfeeding intensity and duration. Although more mothers breastfeed after returning to work now than earlier, research has not documented the strategies that mothers use for combining paid work and breastfeeding or their effect on breastfeeding outcomes. This study examined which strategies are associated with smaller decrements in breastfeeding intensity and longer durations.PARTICIPANTS AND METHODS. We analyzed 810 mothers from the Infant Feeding Practices Study II who worked and breastfed. We used regression and censored regression models to analyze 4 strategies that mothers used to combine these 2 activities: (1) feed directly from the breast only; (2) both pump and feed directly; (3) pump only; and (4) neither pump nor breastfeed during the work day. Outcomes were the difference in percentage of milk feeds that were breast milk between the month before and after return to work and duration of breastfeeding after return to work.RESULTS. Forty-three percent of mothers pumped milk at work only; 32% fed the infant directly from the breast only. These 2 strategies, along with pumping and feeding directly, were statistically similar and superior to neither pumping nor breastfeeding during the work day for the outcome of change in breastfeeding intensity. For the outcome of breastfeeding duration, the 2 strategies that included directly feeding from the breast were associated with longer duration than pumping only, whereas the strategy of neither pumping nor breastfeeding during the work day was associated with the shortest duration.CONCLUSIONS. Feeding the infant from the breast during the work day is the most effective strategy for combining breastfeeding and work. Ways to enable direct feeding include on-site child care, telecommuting, keeping the infant at work, allowing the mother to leave work to go to the infant, and having the infant brought to the work site. Establishing ways for mothers to feed from the breast after return to work is important to meet US breastfeeding goals.
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; sara.fein@fda.hhs.gov
U2 - PMID: 18829832.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105687835&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687838
T1 - Prevalence of breast milk expression and associated factors.
AU - Labiner-Wolfe J
AU - Fein SB
AU - Shealy KR
AU - Wang C
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687838. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Attitude to Breast Feeding
KW - Breast Feeding -- Evaluation
KW - Breast Feeding -- Physiology
KW - Adult
KW - Breast Feeding -- Psychosocial Factors
KW - Chi Square Test
KW - Data Analysis Software
KW - Female
KW - Fisher's Exact Test
KW - Funding Source
KW - Infant
KW - Infant Formula -- Utilization
KW - Logistic Regression
KW - Maternal Attitudes
KW - Multivariate Analysis
KW - Nutritional Assessment
KW - Odds Ratio
KW - Prospective Studies
KW - Questionnaires
KW - Socioeconomic Factors
KW - United States Department of Health and Human Services
KW - United States Food and Drug Administration
KW - Human
SP - S63
EP - 8
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES. Our goal was to describe the prevalence of any, occasional, and regular breast milk expression, mothers' reasons for expressing their milk, and sociodemographic factors associated with breast milk expression.PARTICIPANTS AND METHODS. Breastfeeding mothers participating in the 2005-2007 Infant Feeding Practices Study II formed the cohort for these analyses, which were conducted among those with infants in 3 age groups: 1.5 to 4.5 months (n = 1564); >4.5 to 6.5 months (n = 1128); and >6.5 to 9.5 months (n = 914). For the analyses we used frequency and stepwise multiple logistic regression procedures.RESULTS. Eighty-five percent of breastfeeding mothers of infants in the youngest age group had successfully expressed milk at some time since their infant was born. When asked only about the previous 2-week period, 68% of the breastfeeding mothers of infants in this youngest age group had expressed milk, with 43% having done so occasionally and 25% on a regular schedule. Approximately one quarter of breastfeeding mothers of infants in the 2 older infant age groups also expressed milk on a regular schedule. The percentage of mothers expressing milk decreased with increasing infant age. Mothers expressed milk for various reasons. The most frequently cited reason was to get breast milk for someone else to feed their infant. In all 3 age groups, reporting any breast milk expression, compared with none, was positively associated with maternal employment, higher income, lack of previous breastfeeding experience, and living in the Midwest versus the West. In all 3 age groups, expressing milk on a regular schedule, compared with occasionally, was positively associated with maternal employment and the use of an electric versus manual breast pump.CONCLUSIONS. Breast milk expression is a very common practice. It is associated most strongly with maternal employment, a recognized barrier to breastfeeding.
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; judy.labiner@fda.hhs.gov
U2 - PMID: 18829833.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105687838&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687840
T1 - Infant formula-handling education and safety.
AU - Labiner-Wolfe J
AU - Fein SB
AU - Shealy KR
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687840. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Health Education
KW - Infant Formula -- Adverse Effects
KW - Infant Formula -- Utilization
KW - Maternal Attitudes
KW - Adult
KW - Breast Feeding
KW - Child Safety
KW - Data Analysis Software
KW - Female
KW - Food Contamination
KW - Funding Source
KW - Health Beliefs
KW - Infant
KW - Infant Formula -- Microbiology
KW - Infant, Newborn
KW - Multiple Logistic Regression
KW - Nutrition Education
KW - Prospective Studies
KW - Questionnaires
KW - United States
KW - Human
SP - S85
EP - 90
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES. Our goal was to assess the extent to which mothers learn about proper handling of infant formula from health professionals and package labels; mothers' beliefs about the likelihood of germs being in infant formula and the importance of following safe-use directions; whether they take measures while handling infant formula to prevent foodborne illnesses and injury to their infants; and maternal characteristics associated with unsafe infant formula-handling practices.PARTICIPANTS AND METHODS. The study cohort consisted of mothers participating in the 2005-2007 Infant Feeding Practices Study II who fed their infant formula. We conducted frequency and multiple logistic regression analyses. Sample sizes for the analyses ranged from 860 to 1533.RESULTS. The majority of formula-feeding mothers did not receive instruction on formula preparation (77%) or storage (73%) from a health professional. Thirty percent did not read some of the safe-use directions on the formula package label; an approximately equal percentage (38%) thought that both powdered (which is not sterile) and ready-to-feed (which is sterile) formula were unlikely to contain germs; and 85% believed that following safe-storage directions was very important. Among the mothers of the youngest infants analyzed, 55% did not always wash their hands with soap before preparing infant formula, 32% did not adequately wash bottle nipples between uses, 35% heated formula bottles in a microwave oven, and 6% did not always discard formula left standing for >2 hours. The prevalence of these unsafe practices was similar among mothers of older infants. No consistent pattern of maternal characteristics was associated with unsafe practices.CONCLUSIONS. Many mothers do not follow safe practices when preparing infant formula. Additional research is needed to understand why more mothers do not follow safe formula-handling recommendations.
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; judy.labiner@fda.hhs.gov
U2 - PMID: 18829836.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105687840&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687841
T1 - Selected complementary feeding practices and their association with maternal education.
AU - Fein SB
AU - Labiner-Wolfe J
AU - Scanlon KS
AU - Grummer-Strawn LM
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687841. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Infant Feeding -- Evaluation
KW - Infant Feeding, Supplemental -- Methods
KW - Maternal Attitudes
KW - Nutrition Education
KW - Chi Square Test
KW - Data Analysis Software
KW - Dietary Carbohydrates
KW - Dietary Proteins
KW - Educational Status
KW - Food Habits
KW - Funding Source
KW - Health Beliefs
KW - Human
KW - Nutritional Requirements
KW - Questionnaires
KW - Socioeconomic Factors
KW - Time Factors
KW - United States
SP - S91
EP - 7
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE. As infants transition from a milk-based diet to one that includes most food groups, the timing of the transition, how infants are fed, and the quality of their diet can have important health implications. Our objective is to describe these factors for US infants.METHODS. We analyzed data from the Infant Feeding Practices Study II. Sample sizes varied for relevant questions from ~1600 to ~2400. We analyzed the prevalence of 14 feeding practices and their association with the mothers' education and also examined participants' use of commercial baby foods.RESULTS. Approximately 21% of the mothers introduced solid foods before 4 months; 7% introduced solids after 6 months. Twenty-nine percent of the mothers introduced >3 new foods per week to infants aged 5 to 10 months. Approximately 20% of the mothers fed juice before 6 months, fed cow's milk before 12 months, and fed infants <5 times per day after 5 months. Fourteen percent of the mothers chewed food for their infant. Approximately 15% of the mothers fed <1 serving daily of either a fruit or vegetable to infants aged >/= 9 months, half added salt to their infant's food, and more than one third who added salt used noniodized salt. Approximately 20% fed reduced-fat cow's milk at 1 year. Almost half of the 10-month-old infants had eaten restaurant food in a restaurant in the previous week, 22% had eaten carry-out food, and 28% had eaten either type of restaurant food >/= 2 times. The prevalence of 8 of the 14 unhealthful infant feeding practices we examined was inversely associated with maternal education.CONCLUSIONS. Nutrition and feeding guidance should be especially targeted to mothers with a high school education or less.
SN - 0031-4005
AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, HFS 020, College Park, MD 20740; sara.fein@fda.hhs.gov
U2 - PMID: 18829837.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105687841&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105687842
T1 - Maternally reported food allergies and other food-related health problems in infants: characteristics and associated factors.
AU - Luccioli S
AU - Ross M
AU - Labiner-Wolfe J
AU - Fein SB
Y1 - 2008/10/02/Oct2008 Supplement 2
N1 - Accession Number: 105687842. Language: English. Entry Date: 20081114. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Oct2008 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Funded by the Food and Drug Administration, Centers for Disease Control and Prevention, Office of Women's Health, National Institutes of Health and Maternal and Child Health Bureau in the US Department of Health and Human Services. NLM UID: 0376422.
KW - Food Hypersensitivity -- Epidemiology -- United States
KW - Food Hypersensitivity -- Risk Factors
KW - Infant Feeding -- Evaluation
KW - Adolescence
KW - Adult
KW - Chi Square Test
KW - Data Analysis Software
KW - Female
KW - Food Hypersensitivity -- Diagnosis
KW - Food Hypersensitivity -- Symptoms
KW - Funding Source
KW - Incidence
KW - Infant
KW - Poverty
KW - Prospective Studies
KW - Questionnaires
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - S105
EP - 12
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE. Our goal was to identify the frequency, demographics, and diagnostic characteristics associated with maternally reported food allergies and other food-related health problems among infants aged 99%) ( HbA0 )
KW - Hydrogen peroxide
KW - matrix-assisted laser desorption/ionization ( MALDI )
KW - Oxidative stress
KW - polymerase chain reaction ( PCR )
KW - polymerized αXLHb ( PolyαXLHb )
KW - sodium dodecyl sulfate-polyacrylamide electrophoresis ( SDS-PAGE )
KW - surface plasmon resonance ( SPR )
KW - time of flight ( TOF )
KW - trifluoracetic acid ( TFA )
N1 - Accession Number: 34649000; Vallelian, Florence 1 Pimenova, Tatiana 2 Pereira, Claudia P. 1 Abraham, Bindu 3 Mikolajczyk, Malgorzata G. 3 Schoedon, Gabriele 1 Zenobi, Renato 2 Alayash, Abdu I. 3 Buehler, Paul W. 3; Email Address: paul.buehler@fda.hhs.gov Schaer, Dominik J. 1; Email Address: dominik.schaer@usz.ch; Affiliation: 1: Internal Medicine Research Unit, University of Zurich, Zurich, Switzerland 2: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland 3: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda, MD, USA; Source Info: Oct2008, Vol. 45 Issue 8, p1150; Subject Term: FREE radicals (Chemistry); Subject Term: HYDROGEN peroxide; Subject Term: DISINFECTION & disinfectants; Subject Term: HEMOGLOBIN polymorphisms; Author-Supplied Keyword: αα-crosslinked Hb ( αXLHb ); Author-Supplied Keyword: 5-dibromosalicyl) fumarate ( DBBF ); Author-Supplied Keyword: bis(3; Author-Supplied Keyword: bis(3,5-dibromosalicyl) fumarate ( DBBF ); Author-Supplied Keyword: CD163; Author-Supplied Keyword: disuccinimidyl suberate ( DSS ); Author-Supplied Keyword: Haptoglobin; Author-Supplied Keyword: haptoglobin ( Hp ); Author-Supplied Keyword: Hb-based oxygen carrier ( HBOC ); Author-Supplied Keyword: hemeoxygenase-1 ( HO-1 ); Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: hemoglobin ( Hb ); Author-Supplied Keyword: highly purified Hb (purity>99%) ( HbA0 ); Author-Supplied Keyword: Hydrogen peroxide; Author-Supplied Keyword: matrix-assisted laser desorption/ionization ( MALDI ); Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: polymerase chain reaction ( PCR ); Author-Supplied Keyword: polymerized αXLHb ( PolyαXLHb ); Author-Supplied Keyword: sodium dodecyl sulfate-polyacrylamide electrophoresis ( SDS-PAGE ); Author-Supplied Keyword: surface plasmon resonance ( SPR ); Author-Supplied Keyword: time of flight ( TOF ); Author-Supplied Keyword: trifluoracetic acid ( TFA ); NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2008.07.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34649000&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seo, Y.-J.
AU - Kwon, M.-S.
AU - Choi, H.-W.
AU - Choi, S.-M.
AU - Kim, Y.-W.
AU - Lee, J.-K.
AU - Park, S.-H.
AU - Jung, J.-S.
AU - Suh, H.-W.
T1 - Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli
JO - Neuroscience
JF - Neuroscience
Y1 - 2008/10/15/
VL - 156
IS - 3
M3 - Article
SP - 436
EP - 449
SN - 03064522
AB - Abstract: In the present study, we characterized differential expressions of phosphorylated Ca2+/calmodulin-dependent protein kinase IIα (pCaMKIIα) and phosphorylated extracellular signal-regulated protein (pERK) in the mouse hippocampus induced by various nociceptive stimuli. In an immunoblot study, s.c. injection of formalin and intrathecal (i.t.) injections of glutamate, tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1 β) significantly increased pCaMKIIα expression in the hippocampus, but i.p. injections of acetic acid did not. pERK1/2 expression was also increased by i.t. injection of glutamate, TNF-α, and IL-1β but not by s.c. injections of formalin or i.p. injections of acetic acid. In an immunohistochemical study, we found that increased pCaMKIIα and pERK expressions were mainly located at CA3 or the dentate gyrus of the hippocampus. In a behavioral study, we assessed the effects of PD98059 (a MEK 1/2 inhibitor) and KN-93 (a CaMKII inhibitor) following i.c.v. administration on the nociceptive behaviors induced by i.t. injections of glutamate, pro-inflammatory cytokines (TNF-α or IL-1β), and i.p. injections of acetic acid. PD98059 as well as KN-93 significantly attenuated the nociceptive behavior induced by glutamate, pro-inflammatory cytokines, and acetic acid. Our results suggest that (1) pERKα and pCaMK-II located in the hippocampus are important regulators during the nociceptive processes induced by s.c. formalin, i.t. glutamate, i.t. pro-inflammatory cytokines, and i.p. acetic acid injection, respectively, and (2) the alteration of pERK and pCaMKIIα in nociceptive processing induced by formalin, glutamate, pro-inflammatory cytokines and acetic acid was modulated in a different manner. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - FATTY acids
KW - ACETIC acid
KW - FORMALDEHYDE
KW - Ca2+/calmodulin dependent protein kinase II ( CaMK-II )
KW - extracellular signal-regulated protein kinase ( ERK )
KW - hippocampus
KW - interleukin-1β ( IL-1β )
KW - intrathecal ( i.t. )
KW - pain
KW - phosphate buffer ( PB )
KW - phospho-CaMKII
KW - phospho-ERK
KW - phosphor-Ca2+/calmodulin dependent protein kinase II alpha ( pCaMK-IIα )
KW - phosphor-extracellular signal-regulated protein kinase ( pERK )
KW - Tris-buffered saline containing 0.3% Tween-20 ( TBST )
KW - tumor necrosis factor-α ( TNF-α )
N1 - Accession Number: 34746267; Seo, Y.-J. 1 Kwon, M.-S. 2 Choi, H.-W. 3 Choi, S.-M. 3 Kim, Y.-W. 3 Lee, J.-K. 3 Park, S.-H. 3 Jung, J.-S. 3 Suh, H.-W. 3; Email Address: hwsuh@hallym.ac.kr; Affiliation: 1: Division of Recombinant Product, Biopharmaceutical Bureau, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul, 122-704, Republic of Korea 2: Aerospace Medical Center, Republic of Korea Air Force, Cheongwon-gun, Chungcheongbuk-do, 363-842, Republic of Korea 3: Department of Pharmacology and Institute of Natural Medicine, College of Medicine, Hallym University, 1 Okcheon-dong, Chuncheon, Gangwon-do, 200-702, Republic of Korea; Source Info: Oct2008, Vol. 156 Issue 3, p436; Subject Term: CYTOKINES; Subject Term: FATTY acids; Subject Term: ACETIC acid; Subject Term: FORMALDEHYDE; Author-Supplied Keyword: Ca2+/calmodulin dependent protein kinase II ( CaMK-II ); Author-Supplied Keyword: extracellular signal-regulated protein kinase ( ERK ); Author-Supplied Keyword: hippocampus; Author-Supplied Keyword: interleukin-1β ( IL-1β ); Author-Supplied Keyword: intrathecal ( i.t. ); Author-Supplied Keyword: pain; Author-Supplied Keyword: phosphate buffer ( PB ); Author-Supplied Keyword: phospho-CaMKII; Author-Supplied Keyword: phospho-ERK; Author-Supplied Keyword: phosphor-Ca2+/calmodulin dependent protein kinase II alpha ( pCaMK-IIα ); Author-Supplied Keyword: phosphor-extracellular signal-regulated protein kinase ( pERK ); Author-Supplied Keyword: Tris-buffered saline containing 0.3% Tween-20 ( TBST ); Author-Supplied Keyword: tumor necrosis factor-α ( TNF-α ); NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.neuroscience.2008.08.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brorson, Kurt
AU - Shen, Hong
AU - Lute, Scott
AU - Pérez, Jessica Soto
AU - Frey, Douglas D.
T1 - Characterization and purification of bacteriophages using chromatofocusing
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/10/17/
VL - 1207
IS - 1/2
M3 - Article
SP - 110
EP - 121
SN - 00219673
AB - Abstract: The technique of chromatofocusing was applied to the characterization and purification of three bacteriophages that are routinely used for testing virus filters: φX174, PR772, and PP7. Chemically well-defined eluent buffers were used, instead of the more commonly used chromatofocusing polyampholyte buffers. Chromatographic column packings were selected to minimize band broadening by confining bacteriophage adsorption solely to the exterior particle surface. Under the conditions used it was determined that bacteriophages could be made to focus into narrow bands in a retained pH gradient with recoveries of live phage that ranged from 15 to nearly 100% as determined by a plaque-forming assay. Retention times and apparent isoelectric point data were obtained for samples consisting either of purified bacteriophage, or samples consisting of crude preparations of bacteriophages containing host cell impurities. Isoelectric point estimates were obtained using modified, previously described models. The results obtained suggest that chromatofocusing is a simple and rapid method for obtaining approximate isoelectric points for bacteriophages and probably other types of viruses. It is also likely a useful method for purifying these materials. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC transduction
KW - RAPID methods (Microbiology)
KW - HYDROGEN-ion concentration
KW - NEUTRALIZATION (Chemistry)
KW - BACTERIOPHAGE adsorption
KW - Bacteriophage
KW - Chromatofocusing
KW - pH gradient elution
KW - Virus characterization
KW - Virus purification
N1 - Accession Number: 34649667; Brorson, Kurt 1 Shen, Hong 2 Lute, Scott 1 Pérez, Jessica Soto 2 Frey, Douglas D. 2; Email Address: dfrey1@umbc.edu; Affiliation: 1: Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA 2: Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA; Source Info: Oct2008, Vol. 1207 Issue 1/2, p110; Subject Term: GENETIC transduction; Subject Term: RAPID methods (Microbiology); Subject Term: HYDROGEN-ion concentration; Subject Term: NEUTRALIZATION (Chemistry); Subject Term: BACTERIOPHAGE adsorption; Author-Supplied Keyword: Bacteriophage; Author-Supplied Keyword: Chromatofocusing; Author-Supplied Keyword: pH gradient elution; Author-Supplied Keyword: Virus characterization; Author-Supplied Keyword: Virus purification; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.chroma.2008.08.037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wheeler, K.
AU - Kass, D.
AU - Hoffman, R. S.
AU - Lackovic, M.
AU - Mitchell, Y.
AU - Barrett, R.
AU - Morrissey, B.
AU - Mehler, L.
AU - Diebolt-Brown, B.
AU - Waltz, J.
AU - Schwartz, A.
AU - Calvert, G. M.
AU - Luckhaupt, S. E.
T1 - Illnesses and Injuries Related to Total Release Foggers -- Eight States, 2001-2006.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/10/17/
VL - 57
IS - 41
M3 - Article
SP - 1125
EP - 1129
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article reports on illnesses and injuries that were associated with exposures to total release foggers (TRF), the pesticide products designed to fill an area with insecticide. A total of 466 TRF-related illnesses or injuries were identified during 2001-2006 in eight U.S. states, including California, Florida, Louisiana, Michigan, New York, Oregon, Texas and Washington. It outlines ways by which the risk of TRF-related health effects would be reduced or prevented.
KW - PESTICIDES
KW - AGRICULTURAL chemicals
KW - POISONS
KW - DISEASES
KW - WOUNDS & injuries
KW - U.S. states
KW - UNITED States
N1 - Accession Number: 35156934; Wheeler, K. 1 Kass, D. 1 Hoffman, R. S. 2 Lackovic, M. 3 Mitchell, Y. 4 Barrett, R. 5 Morrissey, B. 6 Mehler, L. 7 Diebolt-Brown, B. 8 Waltz, J. 9 Schwartz, A. 10 Calvert, G. M. 11 Luckhaupt, S. E. 12; Affiliation: 1: New York City Dept of Health and Mental Hygiene 2: New York City Poison Control Center 3: Louisiana Dept of Health and Hospitals 4: New York State Dept of Health 5: Florida Dept of Health 6: Washington State Dept of Health 7: California Dept of Pesticide Regulation 8: Texas Dept of State Health Svcs. 9: Oregon Dept of Human Svcs. 10: Michigan Dept of Community Health 11: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health 12: EIS Officer, CDC; Source Info: 10/17/2008, Vol. 57 Issue 41, p1125; Subject Term: PESTICIDES; Subject Term: AGRICULTURAL chemicals; Subject Term: POISONS; Subject Term: DISEASES; Subject Term: WOUNDS & injuries; Subject Term: U.S. states; Subject Term: UNITED States; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Xiaoying
AU - Tryndyak, Volodymyr
AU - Apostolov, Eugene O.
AU - Yin, Xiaoyan
AU - Shah, Sudhir V.
AU - Pogribny, Igor P.
AU - Basnakian, Alexei G.
T1 - Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation
JO - Cancer Letters
JF - Cancer Letters
Y1 - 2008/10/18/
VL - 270
IS - 1
M3 - journal article
SP - 132
EP - 143
SN - 03043835
AB - Abstract: Analysis of promoter sequences of all known human cytotoxic endonucleases showed that endonuclease G (EndoG) is the only endonuclease that contains a CpG island, a segment of DNA with high G+C content and a site for methylation, in the promoter region. A comparison of three human prostate cancer cell lines showed that EndoG is highly expressed in 22Rv1 and LNCaP cells. In PC3 cells, EndoG was not expressed and the EndoG CpG island was hypermethylated. The expression of EndoG correlated positively with sensitivity to cisplatin and etoposide, and the silencing of EndoG by siRNA decreased the sensitivity of the cells to the chemotherapeutic agents in the two EndoG-expressing cell lines. 5-aza-2′-deoxycytidine caused hypomethylation of the EndoG promoter in PC3 cells, induced EndoG mRNA and protein expression, and made the cells sensitive to both cisplatin and etoposide. The acetylation of histones by trichostatin A, the histone deacetylase inhibitor, induced EndoG expression in 22Rv1 cells, while it had no such effect in PC3 cells. These data are the first indication that EndoG may be regulated by methylation of its gene promoter, and partially by histone acetylation, and that EndoG is essential for prostate cancer cell death in the used models. [Copyright &y& Elsevier]
AB - Copyright of Cancer Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE cancer
KW - CANCER cells
KW - DRUG therapy
KW - METHYLATION
KW - CELL lines
KW - ENDONUCLEASES
KW - CELL death
KW - ANTINEOPLASTIC agents
KW - CISPLATIN
KW - DNA
KW - ESTERASES
KW - ETOPOSIDE
KW - GENES
KW - PROSTATE tumors
KW - DNA methylation
KW - DRUGS -- Physiological effect
KW - Cell death
KW - Cisplatin
KW - Endonuclease G
KW - Prostate cancer
N1 - Accession Number: 34202916; Wang, Xiaoying 1,2 Tryndyak, Volodymyr 3 Apostolov, Eugene O. 1,2 Yin, Xiaoyan 1 Shah, Sudhir V. 1,4 Pogribny, Igor P. 3 Basnakian, Alexei G. 1,2,4; Email Address: basnakianalexeig@uams.edu; Affiliation: 1: Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA 2: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham, # 638, Little Rock, AR 72205, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA 4: Central Arkansas Veterans Healthcare System, Little Rock, AR, USA; Source Info: Oct2008, Vol. 270 Issue 1, p132; Subject Term: PROSTATE cancer; Subject Term: CANCER cells; Subject Term: DRUG therapy; Subject Term: METHYLATION; Subject Term: CELL lines; Subject Term: ENDONUCLEASES; Subject Term: CELL death; Subject Term: ANTINEOPLASTIC agents; Subject Term: CISPLATIN; Subject Term: DNA; Subject Term: ESTERASES; Subject Term: ETOPOSIDE; Subject Term: GENES; Subject Term: PROSTATE tumors; Subject Term: DNA methylation; Subject Term: DRUGS -- Physiological effect; Author-Supplied Keyword: Cell death; Author-Supplied Keyword: Cisplatin; Author-Supplied Keyword: Endonuclease G; Author-Supplied Keyword: Prostate cancer; Number of Pages: 12p; Document Type: journal article
L3 - 10.1016/j.canlet.2008.04.053
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Karpf, Adam R.
AU - James, Smitha R.
AU - Melnyk, Stepan
AU - Han, Tao
AU - Tryndyak, Volodymyr P.
T1 - Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet
JO - Brain Research
JF - Brain Research
Y1 - 2008/10/27/
VL - 1237
M3 - Article
SP - 25
EP - 34
SN - 00068993
AB - Abstract: The maintenance of the cellular epigenomic landscape, which depends on the status of the one-carbon metabolic pathway, is essential for normal central nervous system development and function. In the present study, we examined the epigenetic alterations in the brains of Fisher 344 rats induced by the long-term administration of a diet lacking of essential one-carbon nutrients, methionine, choline, and folic acid. The results demonstrated that feeding a folate/methyl-deficient diet causes global DNA hypermethylation as indicated by an increase of genomic 5-methyl-2′-deoxycytidine (5mdC) content and more importantly, by an increase of methylation within unmethylated CpG-rich DNA domains. Interestingly, these epigenetic changes were opposite to those observed in the livers of the same folate/methyl-deficient rats. The hypermethylation changes were associated with an increased protein expression of de novo DNA methyltransferase DNMT3a and methyl-CpG-binding protein 2. Additionally, the gene expression profiling identified 33 significantly up- or down-regulated genes (fold change ≥1.5 and p ≤0.05) in the brains of rats fed a folate/methyl-deficient diet for 36 weeks. Interestingly, we detected an up-regulation of regulatory factor X, 3 (Rfx3) gene, a sequence-specific DNA-binding protein, that mediates the transcriptional activation of silenced by methylation genes, which may be an adaptive protective brain response to hypermethylation. Together, these data suggest that the proper maintenance of the epigenomic landscape in normal brain depends on the adequate supply of essential nutrients involved in the metabolism of methyl groups. [Copyright &y& Elsevier]
AB - Copyright of Brain Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - RATS as laboratory animals
KW - CENTRAL nervous system
KW - DIETARY supplements
KW - NEURAL development
KW - METHYLATION
KW - DNA-protein interactions
KW - Brain
KW - DNA methylation
KW - Epigenetics
KW - Folate/methyl-deficient diet
KW - Gene expression
KW - Rat
N1 - Accession Number: 34674623; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Karpf, Adam R. 2 James, Smitha R. 2 Melnyk, Stepan 3 Han, Tao 4 Tryndyak, Volodymyr P. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA 3: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 4: Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Oct2008, Vol. 1237, p25; Subject Term: GENE expression; Subject Term: RATS as laboratory animals; Subject Term: CENTRAL nervous system; Subject Term: DIETARY supplements; Subject Term: NEURAL development; Subject Term: METHYLATION; Subject Term: DNA-protein interactions; Author-Supplied Keyword: Brain; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Epigenetics; Author-Supplied Keyword: Folate/methyl-deficient diet; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Rat; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.brainres.2008.07.077
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105627860
T1 - Quality assurance and improvement practice in mental health agencies: roles, activities, targets and contributions.
AU - McMillen C
AU - Zayas LE
AU - Books S
AU - Lee M
Y1 - 2008/11//2008 Nov
N1 - Accession Number: 105627860. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed. Special Interest: Psychiatry/Psychology. NLM UID: 8914574.
KW - Administrative Personnel
KW - Child Health Services
KW - Community Mental Health Services -- Standards
KW - Professional Role
KW - Quality Assurance -- Administration
KW - Accreditation
KW - Child
KW - Missouri
KW - Private Sector
KW - Qualitative Studies
KW - Task Performance and Analysis
KW - Human
SP - 458
EP - 467
JO - Administration & Policy in Mental Health
JF - Administration & Policy in Mental Health
JA - ADM POLICY MENT HEALTH
VL - 35
IS - 6
CY - ,
PB - Springer Science & Business Media B.V.
SN - 0894-587X
AD - Center for Mental Health Services Research George Warren Brown School of Social Work, Washington University in St. Louis, Washington University Campus Box 1196, One Brookings Drive, St. Louis, MO 63130, USA. cmcmille@wustl.edu
U2 - PMID: 18688707.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chan-Tack, Kirk M.
AU - Struble, Kimberly A.
AU - Birnkrant, Debra B.
T1 - Intracranial Hemorrhage and Liver-Associated Deaths Associated with Tipranavir/Ritonavir: Review of Cases from the FDA's Adverse Event Reporting System.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2008/11//
VL - 22
IS - 11
M3 - Article
SP - 843
EP - 850
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - Tipranavir (TPV), a protease inhibitor, has box warnings for intracranial hemorrhage (ICH) and hepatotoxicity (including hepatic failure and death). A box warning is a labeling statement about serious adverse events leading to significant injury and/or death. A box warning is the most serious warning placed in the labeling of a prescription medication. As a result of the respective morbidity and mortality associated with ICH and hepatic failure, the Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) was searched for reports of these adverse events in HIV-infected patients receiving a tipranavir/ritonavir (TPV/r)-based regimen. This search comprised part of the FDA's safety analysis for traditional approval. From July 2006 to March 2007, 10 cases of ICH were identified in AERS. From June 2005 to March 2007, 12 cases of liver-associated deaths were identified. One patient experienced liver failure and fatal ICH. Most patients with these events had additional risk factors. Among patients with liver-associated deaths, 3 had HIV-RNA less than 400 copies per milliliter at the time of hepatic failure. Among 10 patients who discontinued TPV/r when hepatic failure developed, median number of days post-TPV/r to death was 23 (range, 2–69 days). Review of AERS did not identify new safety concerns regarding ICH. Among most patients with liver-associated deaths, death appears to occur soon after hepatic failure develops. If considering TPV/r, careful assessment of risk/benefit is suggested for patients at risk for ICH and hepatic failure. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Hemorrhage
KW - Liver diseases
KW - Liver failure
KW - HIV-positive persons
KW - Arteries
KW - Hepatotoxicology
KW - Medical care
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 35407608; Chan-Tack, Kirk M. 1; Email Address: kirk.chan-tack@fda.hhs.gov; Struble, Kimberly A. 1; Birnkrant, Debra B. 1; Affiliations: 1: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.; Issue Info: Nov2008, Vol. 22 Issue 11, p843; Thesaurus Term: WOUNDS & injuries; Subject Term: Hemorrhage; Subject Term: Liver diseases; Subject Term: Liver failure; Subject Term: HIV-positive persons; Subject Term: Arteries; Subject Term: Hepatotoxicology; Subject Term: Medical care; Subject: United States ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1089/apc.2008.0043
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Carabin, Hélène
AU - Keesee, Marguerite S.
AU - Machado, Linda J.
AU - Brittingham, Timothy
AU - Williams, Lynda
AU - Sonleitner, Nancy K.
AU - Anderson, Kermyt G.
AU - Cajina, Adan
AU - Foster, Morris W.
T1 - Estimation of the Prevalence of AIDS, Opportunistic Infections, and Standard of Care among Patients with HIV/AIDS Receiving Care Along the U.S.-Mexico Border through the Special Projects of National Significance: A Cross-Sectional Study.
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
Y1 - 2008/11//
VL - 22
IS - 11
M3 - Article
SP - 887
EP - 895
PB - Mary Ann Liebert, Inc.
SN - 10872914
AB - There is high demand for care among the Hispanic population in states along the U.S.-Mexico border. The objective is to describe the standard of care received by people living with HIV/AIDS (PLWH/A) at enrollment into one of five Special Projects of National Significance (SPNS) Sites located along the U.S.-Mexico border. This cross-sectional study describes the presence of opportunistic infections (OIs), AIDS status and two types of standard of care received by 707 PLWH/A participating in SPNS. Patients receiving care through SPNS in one of the five sites between June 1, 2002 and December 31, 2003 were invited to participate to the medical chart review component of the study. The association between sociodemographic variables and the prevalence of OIs and AIDS at enrollment was estimated using multivariate hierarchical logistic models. More than one quarter of the 707 participants had at least one OI recorded and 58% of new and 60% of existing patients had AIDS at enrollment in SPNS. The association between being Hispanic and having higher prevalence of OI and AIDS at entry varied by SPNS site. Standard of care was well followed overall. This is the first study describing HIV stage and OI prevalences and standard of care in PLWH/A in all U.S.-Mexico bordering states. Being of Hispanic ethnicity may not fully explain discrepancy in access to care along the border. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIDS Patient Care & STDs is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virus diseases
KW - AIDS patients
KW - Opportunistic infections
KW - Medical care
KW - Cross-sectional method
KW - Multiculturalism
KW - Sociodemographic factors
KW - Mexico
KW - United States
N1 - Accession Number: 35407607; Carabin, Hélène 1; Email Address: helene-carabin@ouhs.edu; Keesee, Marguerite S. 2,3; Machado, Linda J. 4; Brittingham, Timothy 3; Williams, Lynda 1,3; Sonleitner, Nancy K. 3,5; Anderson, Kermyt G. 3; Cajina, Adan 6; Foster, Morris W. 3; Affiliations: 1: Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; 2: K20 Center for Educational and Community Renewal, University of Oklahoma, Norman, Oklahoma.; 3: Center for Applied Social Research, University of Oklahoma, Norman, Oklahoma.; 4: Section of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; 5: Department of Sociology, Anthropology, Social Work, and Criminal Justice. The University of Tennessee at Martin, Martin, Tennessee.; 6: Health Resources and Services Administration, HIV/AIDS Bureau, Special Projects of National Significance, Rockville, Maryland.; Issue Info: Nov2008, Vol. 22 Issue 11, p887; Thesaurus Term: Virus diseases; Subject Term: AIDS patients; Subject Term: Opportunistic infections; Subject Term: Medical care; Subject Term: Cross-sectional method; Subject Term: Multiculturalism; Subject Term: Sociodemographic factors; Subject: Mexico; Subject: United States; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1089/apc.2007.0176
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35407607&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105591441
T1 - Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's Adverse Event Reporting System.
AU - Chan-Tack KM
AU - Struble KA
AU - Birnkrant DB
Y1 - 2008/11//
N1 - Accession Number: 105591441. Language: English. Entry Date: 20090213. Revision Date: 20150818. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9607225.
KW - Hepatotoxicity
KW - HIV Infections -- Drug Therapy
KW - Intracranial Hemorrhage
KW - Protease Inhibitors -- Adverse Effects
KW - Ritonavir -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Adverse Drug Event
KW - Databases
KW - Female
KW - Male
KW - Middle Age
KW - Mortality
KW - United States Food and Drug Administration
KW - Voluntary Reporting
SP - 843
EP - 850
JO - AIDS Patient Care & STDs
JF - AIDS Patient Care & STDs
JA - AIDS PATIENT CARE STDS
VL - 22
IS - 11
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - Abstract Tipranavir (TPV), a protease inhibitor, has box warnings for intracranial hemorrhage (ICH) and hepatotoxicity (including hepatic failure and death). A box warning is a labeling statement about serious adverse events leading to significant injury and/or death. A box warning is the most serious warning placed in the labeling of a prescription medication. As a result of the respective morbidity and mortality associated with ICH and hepatic failure, the Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) was searched for reports of these adverse events in HIV-infected patients receiving a tipranavir/ritonavir (TPV/r)-based regimen. This search comprised part of the FDA's safety analysis for traditional approval. From July 2006 to March 2007, 10 cases of ICH were identified in AERS. From June 2005 to March 2007, 12 cases of liver-associated deaths were identified. One patient experienced liver failure and fatal ICH. Most patients with these events had additional risk factors. Among patients with liver-associated deaths, 3 had HIV-RNA less than 400 copies per milliliter at the time of hepatic failure. Among 10 patients who discontinued TPV/r when hepatic failure developed, median number of days post-TPV/r to death was 23 (range, 2-69 days). Review of AERS did not identify new safety concerns regarding ICH. Among most patients with liver-associated deaths, death appears to occur soon after hepatic failure develops. If considering TPV/r, careful assessment of risk/benefit is suggested for patients at risk for ICH and hepatic failure.
SN - 1087-2914
AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
U2 - PMID: 19025478.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105563967
T1 - Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking greater than or equal to 48 g of alcohol per day.
AU - Signore C
AU - Aros S
AU - Morrow JD
AU - Troendle J
AU - Conley MR
AU - Flanigan EY
AU - Cassorla F
AU - Mills JL
Y1 - 2008/11//
N1 - Accession Number: 105563967. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Obstetric Care; Psychiatry/Psychology. Grant Information: Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and by NIH. NLM UID: 7707242.
KW - Alcohol Drinking -- In Pregnancy
KW - Alcohols -- Pharmacodynamics -- In Pregnancy
KW - Oxidative Stress
KW - Vasoconstriction -- In Pregnancy
KW - Biological Markers -- Urine
KW - Comparative Studies
KW - Creatinine -- Urine
KW - Data Analysis Software
KW - Fatty Acids, Unsaturated -- Urine
KW - Female
KW - Fetal Alcohol Syndrome -- Risk Factors
KW - Fisher's Exact Test
KW - Funding Source
KW - Multiple Logistic Regression
KW - Pregnancy
KW - Prostaglandins -- Urine
KW - Wilcoxon Rank Sum Test
KW - Human
SP - 1893
EP - 1898
JO - Alcoholism: Clinical & Experimental Research
JF - Alcoholism: Clinical & Experimental Research
JA - ALCOHOLISM
VL - 32
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0145-6008
AD - Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, US Department of Health and Human Services, Bethesda, MD
U2 - PMID: 18715278.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Macher, Abe M.
T1 - Anorectal Syphilis.
JO - American Jails
JF - American Jails
Y1 - 2008/11//Nov/Dec2008
VL - 22
IS - 5
M3 - Article
SP - 73
EP - 79
SN - 10560319
AB - The article presents benign and malignant conditions of patients with a clinical manifestation of anorectal syphilis. A 24-year-old male homosexual was complaining of persistent pain and purulent anal discharge at an outpatient clinic after an episode of diarrhea, A 27-year-old male homosexual was presented with rectal bleeding and bilaterally tender inguinal lymphadenopathy. A 24-year-old bisexual man was presumed to have an anorectal abscess.
KW - SYMPTOMS
KW - PATIENTS
KW - SYPHILIS
KW - SEXUALLY transmitted diseases
KW - DISEASES -- Causes & theories of causation
N1 - Accession Number: 35650287; Macher, Abe M. 1; Email Address: abemacher@yahoo.com; Affiliation: 1: United States Public Health Service; Source Info: Nov/Dec2008, Vol. 22 Issue 5, p73; Subject Term: SYMPTOMS; Subject Term: PATIENTS; Subject Term: SYPHILIS; Subject Term: SEXUALLY transmitted diseases; Subject Term: DISEASES -- Causes & theories of causation; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105575742
T1 - National Healthcare Safety Network (NHSN) Report, data summary for 2006 through 2007, issued November 2008 [corrected] [published erratum appears in AM J INFECT CONTROL 2009 Jun;37(5):425].
AU - Edwards JR
AU - Peterson KD
AU - Andrus ML
AU - Dudeck MA
AU - Pollock DA
AU - Horan TC
Y1 - 2008/11//
N1 - Accession Number: 105575742. Corporate Author: National Healthcare Safety Network Facilities. Language: English. Entry Date: 20090123. Revision Date: 20150819. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Critical Care; Pediatric Care. NLM UID: 8004854.
KW - Cross Infection -- Epidemiology -- United States
KW - Cross Infection -- Trends -- United States
KW - Bacteremia
KW - Birth Weight
KW - Catheter-Related Infections
KW - Catheters, Urinary -- Adverse Effects
KW - Catheters, Urinary -- Utilization
KW - Centers for Disease Control and Prevention (U.S.)
KW - Central Venous Catheters -- Adverse Effects
KW - Central Venous Catheters -- Utilization
KW - Coronary Artery Bypass -- Adverse Effects
KW - Descriptive Statistics
KW - Disease Surveillance
KW - Epidemiological Research
KW - Hospitals -- Classification
KW - Infant, Newborn
KW - Intensive Care Units
KW - Intensive Care Units, Neonatal
KW - Intensive Care Units, Pediatric
KW - Length of Stay
KW - Pneumonia, Ventilator-Associated
KW - Respiration, Artificial -- Utilization
KW - Risk Assessment
KW - Surgical Wound Infection
KW - Umbilical Veins
KW - United States
KW - Human
SP - 609
EP - 626
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 36
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 0196-6553
AD - National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA. jredwards@cdc.gov
U2 - PMID: 18992647.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105581929
T1 - Commentary: state snapshots -- a picture of unacceptable variation: are we destined to live with 'geography is destiny'?
AU - Brady J
AU - Ho K
AU - Clancy CM
Y1 - 2008/11//Nov/Dec2008
N1 - Accession Number: 105581929. Language: English. Entry Date: 20090116. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Geographic Factors
KW - Health Services Accessibility
KW - Quality Improvement
KW - Quality of Health Care
KW - Patient Centered Care
KW - Patient Safety
KW - Race Factors
KW - Socioeconomic Factors
KW - Treatment Outcomes
KW - United States
KW - World Wide Web
SP - 492
EP - 495
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 23
IS - 6
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 19001105.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105581929&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105575563
T1 - State-level health care access and use among children in US immigrant families.
AU - Yu SM
AU - Huang ZJ
AU - Kogan MD
Y1 - 2008/11//
N1 - Accession Number: 105575563. Language: English. Entry Date: 20090109. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Pediatric Care; Public Health. Grant Information: Office of Data and Program Development, Maternal and Child Health Bureau. NLM UID: 1254074.
KW - Child Health Services -- Utilization
KW - Health Services Accessibility
KW - Health Status
KW - Immigrants
KW - State Health Plans
KW - Adolescence
KW - Birth Place
KW - Chi Square Test
KW - Child
KW - Child Welfare
KW - Child, Preschool
KW - Confidence Intervals
KW - Correlational Studies
KW - Eligibility Determination
KW - Ethnic Groups
KW - Family Characteristics
KW - Female
KW - Funding Source
KW - Human
KW - Infant
KW - Infant, Newborn
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Secondary Analysis
KW - Surveys
KW - United States
SP - 1996
EP - 2003
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 98
IS - 11
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We examined the association between children's state of residence and their access to health care among specific types of immigrant families: foreign-born children, US-born children with 1 foreign-born parent, US-born children with both foreign-born parents, and nonimmigrant families. METHODS: We analyzed data from 12 400 children from the 2003 National Survey of Children's Health in the 6 states with the highest proportion of immigrants (California, Florida, Illinois, New York, New Jersey, and Texas). RESULTS: Multivariable analyses indicated that among foreign-born children, those living in California, Illinois, and Texas were more likely to lack access to health care compared with those living in New York. Among foreign-born children with 1 or 2 US-born parents, Texas children were most likely to lack health insurance. Within nonimmigrant families, children from California, Florida, and Texas had significantly more access and use problems. CONCLUSIONS: Our findings document differential health care access and use among states for specific immigrant family types.
SN - 0090-0036
AD - Maternal and Child Health Bureau, HRSA, Rockville, MD 20857, USA; syu@hrsa.gov
U2 - PMID: 18799781.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Elkins, Christopher A.
AU - Muñoz, María Enriqueta
AU - Mullis, Lisa B.
AU - Stingley, Robin L.
AU - Hart, Mark E.
T1 - Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production
JO - Anaerobe
JF - Anaerobe
Y1 - 2008/11//
VL - 14
IS - 5
M3 - Article
SP - 261
EP - 267
SN - 10759964
AB - Abstract: The inhibitory activities of 39 strains representing 20 different species of Lactobacillus toward a menstrual toxic shock syndrome (TSS) Staphylococcus aureus archetype strain MN8 were investigated. Nearly every strain (38 of 39) produced an inhibitory effect under both aerobic and anaerobic conditions when assayed on agar medium. In addition, the MN8 inhibition was conserved against at least 10 other clinical TSS S. aureus isolates and, interestingly, required actively growing cultures of Lactobacillus (verified with a two-well co-culture system in broth medium). This general uniform inhibition could be ameliorated by organic buffer (PIPES) supplied in the growth medium and, with only one exception, MRS medium adjusted with non-organic acid (HCl) failed to support growth of TSS strains at or below pH 5.5. By comparison, the vast majority of lactobacilli in this study decreased culture pH to a range of 4–5. Hydrogen peroxide production by the lactobacilli was also assessed and verified by two different methodologies revealing a broad spectrum of phenotypes that, contrary to reports touting its effectiveness, did not seem to correspond with our inhibition studies. Furthermore, resistances to peroxide by MN8, other TSS strains, and a subset of lactobacilli used in this study were nearly identical whereas the S. aureus collection was slightly more sensitive to racemic lactic acid than the lactobacilli. Collectively, these data suggest that the underlying inhibition toward Staphylococcus is generally conserved in Lactobacillus sp. and is related to a common factor in this genus involving promotion of acidic conditions. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LACTOBACILLUS
KW - TOXIC shock syndrome
KW - STAPHYLOCOCCUS aureus
KW - HYDROGEN peroxide
KW - PROBIOTICS
KW - LACTIC acid
KW - Lactic acid
KW - Lactobacillus
KW - Peroxide
KW - Probiotic
KW - Staphylococcus
KW - Toxic shock syndrome
KW - Vaginal microbiota
N1 - Accession Number: 35513446; Elkins, Christopher A. 1; Email Address: chris.elkins@fda.hhs.gov Muñoz, María Enriqueta 2 Mullis, Lisa B. 1 Stingley, Robin L. 1 Hart, Mark E. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA 2: Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Tijuana, Mexico; Source Info: Nov2008, Vol. 14 Issue 5, p261; Subject Term: LACTOBACILLUS; Subject Term: TOXIC shock syndrome; Subject Term: STAPHYLOCOCCUS aureus; Subject Term: HYDROGEN peroxide; Subject Term: PROBIOTICS; Subject Term: LACTIC acid; Author-Supplied Keyword: Lactic acid; Author-Supplied Keyword: Lactobacillus; Author-Supplied Keyword: Peroxide; Author-Supplied Keyword: Probiotic; Author-Supplied Keyword: Staphylococcus; Author-Supplied Keyword: Toxic shock syndrome; Author-Supplied Keyword: Vaginal microbiota; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.anaerobe.2008.08.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, S.
AU - White, D. G.
AU - Friedman, S. L.
AU - Glenn, A.
AU - Blickenstaff, K.
AU - Ayers, S. L.
AU - Abbott, J. W.
AU - Hall-Robinson, E.
AU - McDermotta, P. F.
T1 - Antimicrobial Resistance in Salmonella enterica Serovar Heidelberg Isolates from Retail Meats, Including Poultry, from 2002 to 2006.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2008/11//
VL - 74
IS - 21
M3 - Article
SP - 6656
EP - 6662
SN - 00992240
AB - Salmonella enterica serovar Heidelberg frequently causes food-borne illness in humans. There are few data on the prevalence, antimicrobial susceptibility, and genetic diversity of Salmonella serovar Heidelberg isolates in retail meats. We compared the prevalences of Salmonella serovar Heidelberg in a sampling of 20,295 meats, including chicken breast (a = 5,075), ground turkey (a = 5,044), ground beef (n = 5,100), and pork chops (n = 5,076), collected during 2002 to 2006. Isolates were analyzed for antimicrobial susceptibility and compared genetically using pulsed-field gel electrophoresis (PFGE) and PCR for the blaCMY gene. A total of 298 Salmonella serovar Heidelberg isolates were recovered, representing 21.6% of all Salmonella serovars from retail meats. One hundred seventy-eight (59.7%) were from ground turkey, 110 (36.9%) were from chicken breast, and 10 (3.4%) were from pork chops; none was found in ground beef. One hundred ninety-eight isolates (66.4%) were resistant to at least one compound, and 49 (16.4%) were resistant to at least five compounds. Six isolates (2.0%), all from ground turkey, were resistant to at least nine antimicrobials. The highest resistance in poultry isolates was to tetracycline (39.9%), followed by streptomycin (37.8%), sulfamethoxazole (27.7%), gentamicin (25.7%), kanamycin (21.5%), ampicillin (19.8%), amoxicillin-clavulanic acid (10.4%), and ceftiofur (9.0%). All isolates were susceptible to ceftriaxone and ciprofloxacin. All ceftiofur-resistant strains carried bIaCMY. PFGE using XbaI and BlnI showed that certain clones were widely dispersed in different types of meats and meat brands from different store chains in all five sampling years. These data indicate that Salmonella serovar Heidelberg is a common serovar in retail poultry meats and includes widespread clones of multidrug-resistant strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - MICROBIAL sensitivity tests
KW - MEAT
KW - POULTRY
KW - PULSED-field gel electrophoresis
N1 - Accession Number: 35420264; Zhao, S. 1 White, D. G. 1 Friedman, S. L. 1 Glenn, A. 1 Blickenstaff, K. 1 Ayers, S. L. 1 Abbott, J. W. 1 Hall-Robinson, E. 1 McDermotta, P. F. 1; Email Address: patrick.mcdermott@fda.hhs.gov; Affiliation: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinaiy Medicine, U.S. Food and Drug Administration, Maryland; Source Info: Nov2008, Vol. 74 Issue 21, p6656; Subject Term: SALMONELLA; Subject Term: MICROBIAL sensitivity tests; Subject Term: MEAT; Subject Term: POULTRY; Subject Term: PULSED-field gel electrophoresis; NAICS/Industry Codes: 445210 Meat Markets; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; Number of Pages: 7p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1128/AEM.01249-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jakab, Ferenc
AU - Horváth, Győző
AU - Ferenczi, Emőke
AU - Sebők, Judit
AU - Szűcs, György
T1 - First detection of Tula hantaviruses in Microtus arvalis voles in Hungary.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2008/11//
VL - 153
IS - 11
M3 - Article
SP - 2093
EP - 2096
SN - 03048608
AB - Tula hantavirus (TULV) is a member of the genus Hantavirus, family Bunyaviridae and is mainly carried by the European common vole ( Microtus arvalis). In order to detect TULV, we tested Microtus arvalis ( MAR) and Microtus subterraneus ( MSU) voles captured in two different locations of the Southern Transdanubian region of Hungary. The viral genome was detectable in 37% of the tested MAR voles but, interestingly, was absent in all MSU. Phylogenetic analysis performed with a partial coding sequence of the capsid gene showed that Hungarian TULV strains clustered with viruses detected in western Slovakia and in the Czech Republic. To the best of our knowledge, this is the first report on the identification of TULV detected in MAR voles in the Transdanubian region of Hungary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MURIDAE
KW - VOLES
KW - GENETICS
KW - MICROORGANISMS
KW - GENOMES
N1 - Accession Number: 35166542; Jakab, Ferenc 1,2; Email Address: jakabf@gamma.ttk.pte.hu Horváth, Győző 1 Ferenczi, Emőke 3 Sebők, Judit 4 Szűcs, György 2; Affiliation: 1: Institute of Biology, University of Pécs, Ifjúság út 6, 7624 Pecs, Hungary 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary 3: Department of Viral Diagnostics, Reference Laboratory of Viral Zoonozes, National Center for Epidemiology, Budapest, Hungary 4: 2nd Department of Medicine and Nephrology, University Hospital, Pecs, Hungary; Source Info: Nov2008, Vol. 153 Issue 11, p2093; Subject Term: MURIDAE; Subject Term: VOLES; Subject Term: GENETICS; Subject Term: MICROORGANISMS; Subject Term: GENOMES; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1007/s00705-008-0216-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kozora, Elizabeth
AU - Hanly, John G.
AU - Lapteva, Larissa
AU - Filley, Christopher M.
T1 - Cognitive Dysfunction in Systemic Lupus Erythematosus: Past, Present, and Future.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2008/11//
VL - 58
IS - 11
M3 - Article
SP - 3286
EP - 3298
SN - 00043591
AB - The article presents a study which concerns the research approaches on cognitive dysfunction in systematic lupus erythemathosus (SLE). It notes that neuropsychiatric SLE (NPSLE) was thought to be a single entity in the 1950s and 1960s, and that characterization on such patients demonstrated diverse pathogenic mechanisms in the 1970s. The results of the study show that new advances in the process of researches conducted will provide guidance to future investigations.
KW - SYSTEMIC lupus erythematosus
KW - MEDICAL research
KW - NEUROPSYCHIATRY
KW - METHODOLOGY
KW - PATIENTS
N1 - Accession Number: 35340223; Kozora, Elizabeth 1; Email Address: kozorae@njc.org Hanly, John G. 2 Lapteva, Larissa 3 Filley, Christopher M. 4; Affiliation: 1: National Jewish Medical and Research Center, Denver, Colorado, University of Colorado Denver School of Medicine, and Hospital for Special Surgery, New York, New York 2: Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada 3: US Food and Drug Administration, Bethesda, Maryland 4: University of Colorado Denver School of Medicine, and Denver Veterans Affairs Medical Center, Denver, Colorado; Source Info: Nov2008, Vol. 58 Issue 11, p3286; Subject Term: SYSTEMIC lupus erythematosus; Subject Term: MEDICAL research; Subject Term: NEUROPSYCHIATRY; Subject Term: METHODOLOGY; Subject Term: PATIENTS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1002/art.23991
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xu, Fei
AU - Karnaukhova, Elena
AU - Vostal, Jaroslav G
T1 - Human cellular prion protein interacts directly with clusterin protein
JO - BBA - Molecular Basis of Disease
JF - BBA - Molecular Basis of Disease
Y1 - 2008/11//
VL - 1782
IS - 11
M3 - Article
SP - 615
EP - 620
SN - 09254439
AB - Abstract: Prion protein is a glycosyl-phosphatidyl-inositol anchored glycoprotein localized on the surface and within a variety of cells. Its conformation change is thought to be essential for the proliferation of prion neurodegenerative diseases. Using the yeast two-hybrid assay we identified an interaction between prion protein and clusterin, a chaperone glycoprotein. This interaction was confirmed in a mammalian system by in vivo co-immunoprecipitation and in vitro by circular dichroism analysis. Through deletion mapping analysis we demonstrated that the α subunit, but not the β subunit, of clusterin binds to prion and that the C-terminal 62 amino acid segment of the putative α helix region of clusterin is essential for the binding interaction. The full prion protein as well as the N-terminal section (aa 23–95) and C-terminal (aa 96–231) were shown to interact with clusterin. These findings provide new insights into the molecular mechanisms of interaction between prion and clusterin protein and contribute to the understanding of prion protein''s physiological function. [Copyright &y& Elsevier]
AB - Copyright of BBA - Molecular Basis of Disease is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIONS
KW - PROTEIN-protein interactions
KW - CLUSTERIN
KW - GLYCOPROTEINS
KW - CELL membranes
KW - PROTEIN conformation
KW - Chaperone
KW - Clusterin
KW - Prion
KW - Protein interaction
KW - Two-hybrid system
N1 - Accession Number: 35071865; Xu, Fei 1 Karnaukhova, Elena 1 Vostal, Jaroslav G; Email Address: jaroslav.vostal@fda.hhs.gov; Affiliation: 1: Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD, USA; Source Info: Nov2008, Vol. 1782 Issue 11, p615; Subject Term: PRIONS; Subject Term: PROTEIN-protein interactions; Subject Term: CLUSTERIN; Subject Term: GLYCOPROTEINS; Subject Term: CELL membranes; Subject Term: PROTEIN conformation; Author-Supplied Keyword: Chaperone; Author-Supplied Keyword: Clusterin; Author-Supplied Keyword: Prion; Author-Supplied Keyword: Protein interaction; Author-Supplied Keyword: Two-hybrid system; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bbadis.2008.08.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35071865&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petricciani, John
AU - Sheets, Rebecca
T1 - An overview of animal cell substrates for biological products
JO - Biologicals
JF - Biologicals
Y1 - 2008/11//
VL - 36
IS - 6
M3 - Article
SP - 359
EP - 362
SN - 10451056
AB - Abstract: The issue of which cells to use as substrates for the production of biological products, and especially vaccines, has been with us in one form or another ever since the development of cell cultures in the 1950s. The major cell substrate events that occurred over the past 50 years are reviewed briefly. Although numerous conferences were held during that period, incomplete resolution of some cell substrate issues has remained. Specifically, the potential oncogenicity of cellular DNA derived from continuous cell lines, and the tests that are used to rule out the presence of adventitious agents have been recognized as areas that could benefit greatly from studies using state-of-the-art techniques. A collaborative effort involving WHO, NIAID, and IABS resulted from consensus recommendations of a 2004 conference, and the prospects for revised guidance in the near future on the characterization and use of animal cell substrates are bright. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINES
KW - BIOLOGICAL products
KW - DRUG development
KW - ANIMAL materia medica
KW - DNA
KW - Biological products
KW - Cell substrates
KW - Vaccines
KW - WORLD Health Organization
N1 - Accession Number: 35513024; Petricciani, John 1; Email Address: jpmdpsca@aol.com Sheets, Rebecca 2; Affiliation: 1: John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA 2: Captain, U.S. Public Health Service, NIH/NIAID, Room 5145, 6700B Rockledge Drive, MSC-7628, Bethesda, MD 20892-7628, USA; Source Info: Nov2008, Vol. 36 Issue 6, p359; Subject Term: VACCINES; Subject Term: BIOLOGICAL products; Subject Term: DRUG development; Subject Term: ANIMAL materia medica; Subject Term: DNA; Author-Supplied Keyword: Biological products; Author-Supplied Keyword: Cell substrates; Author-Supplied Keyword: Vaccines; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.biologicals.2008.06.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kyungeun Cha
AU - Hye-Won Hong
AU - Yeon-Gil Choi
AU - Min Joo Lee
AU - Jong Hoon Park
AU - Hee-Kwon Chae
AU - Gyuha Ryu
AU - Heejoon Myung
T1 - Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles.
JO - Biotechnology Letters
JF - Biotechnology Letters
Y1 - 2008/11//
VL - 30
IS - 11
M3 - Article
SP - 1893
EP - 1899
SN - 01415492
AB - Mice were fed either 13 nm silver nanoparticles or 2–3.5 μm silver microparticles. The livers were then obtained after 3 days and subjected to a histopathological analysis. The nanoparticle-fed and microparticle-fed livers both exhibited lymphocyte infiltration in the histopathological analysis, suggesting the induction of inflammation. In vitro, a human hepatoma cell line (Huh-7) was treated with the same silver nanoparticles and microparticles. The mitochondrial activity and glutathione production were hardly affected. However, the DNA contents decreased 15% in the nanoparticle-treated cells and 10% in the microparticle-treated cell, suggesting a more potent induction of apoptosis by the nanoparticles. From a microarray analysis of the RNA from the livers of the nano- and micro-particle-fed mice, the expression of genes related to apoptosis and inflammation was found to be altered. These gene expression changes in the nanoparticle-treated livers lead to phenotypical changes, reflecting increased apoptosis and inflammation. The changes in the gene expression were confirmed by using a semi-quantitative RT-PCR. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology Letters is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nucleic acids
KW - Nanoparticles
KW - Gene expression
KW - Genes
KW - Hepatoma
KW - DNA
KW - Cytotoxicity
KW - Gene expression profile
KW - Mouse liver
KW - Nanoparticle
KW - Silver
N1 - Accession Number: 34426223; Kyungeun Cha 1; Hye-Won Hong 1; Yeon-Gil Choi 1; Min Joo Lee 2; Jong Hoon Park 2; Hee-Kwon Chae 3; Gyuha Ryu 4; Heejoon Myung 1; Email Address: hjmyung@hufs.ac.kr; Affiliations: 1: Department of Bioscience and Biotechnology , Hankuk University of Foreign Studies , Yong-In, Kyung-Gi Do 449-791 Korea; 2: Department of Biological Science , Sookmyung Women’s University , Seoul 140-742 Korea; 3: Department of Chemistry Education , Seoul National University , Seoul 151-748 Korea; 4: Korea Food and Drug Administration , Seoul 122-704 Korea; Issue Info: Nov2008, Vol. 30 Issue 11, p1893; Thesaurus Term: Nucleic acids; Subject Term: Nanoparticles; Subject Term: Gene expression; Subject Term: Genes; Subject Term: Hepatoma; Subject Term: DNA; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: Gene expression profile; Author-Supplied Keyword: Mouse liver; Author-Supplied Keyword: Nanoparticle; Author-Supplied Keyword: Silver; Number of Pages: 7p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 2 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1007/s10529-008-9786-2
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xing-Jie Liang
AU - Jun-Jie Yin
AU - Barbara Taylor
AU - Winkovitch, Stephen M.
AU - GarWeld, Susan H.
AU - Ding-Wu Shen
AU - Gottesman, Michael M.
AU - Aszalos, Adorjan
T1 - Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines.
JO - Cancer Chemotherapy & Pharmacology
JF - Cancer Chemotherapy & Pharmacology
Y1 - 2008/11//
VL - 62
IS - 6
M3 - Article
SP - 977
EP - 984
SN - 03445704
AB - Although cisplatin is a frequently used cancer chemotherapeutic drug, its effectiveness is hindered by the development of resistance in cancer cells. In order to understand the reason(s) for this resistance, the mechanism of uptake of cisplatin into cells must be characterized. While several previous studies showed structural differences between cisplatin-sensitive and resistant cells, the influence of microfilaments, known to affect transport of molecules into cells, and the influence of certain biophysical characteristics of the plasma membrane needed clarification. We show that resistant human epidermal carcinoma (KB-CP20) and liver carcinoma (BEL-7404-CP20) cells become relatively more resistant if their already weak microfilaments are degraded by cytochalasin B treatment (.5–2 μM). The sensitive counterparts of these cells with intact microfilaments are not significantly affected by this treatment. We also show that the “fluidity” of the plasma membrane and the membrane potential of the sensitive and resistant cells studied do not appear to influence the uptake of cisplatin into the cells. Our results suggest that the status of the microfilament system influences the mechanism of uptake of cisplatin into cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cancer Chemotherapy & Pharmacology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CISPLATIN
KW - ALKYLATING agents
KW - ANTINEOPLASTIC agents
KW - CHLORIDES
KW - CANCER treatment
KW - Carcinoma cell lines
KW - Cisplatin
KW - Cytochalasin B
KW - Electron spin resonance
KW - Microfilaments
KW - MicroWlaments
N1 - Accession Number: 34284320; Xing-Jie Liang 1,2 Jun-Jie Yin 3 Barbara Taylor 4 Winkovitch, Stephen M. 5 GarWeld, Susan H. 5 Ding-Wu Shen 1 Gottesman, Michael M. 1 Aszalos, Adorjan 1; Email Address: aszalosa@nih.gov; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA 2: Division of Nanomedicine and Nanobiology, National Center of Nanoscience and Technology, Zhongguancun, 100080 Beijing, China 3: Instrumentation and Biophysics Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA 4: Laboratory of Cancer Biology and Genetics, NIH, Bethesda, MD 20892, USA 5: Laboratory of Experimental Carcinogenesis, NIH, Bethesda, MD 20892, USA; Source Info: Nov2008, Vol. 62 Issue 6, p977; Subject Term: CISPLATIN; Subject Term: ALKYLATING agents; Subject Term: ANTINEOPLASTIC agents; Subject Term: CHLORIDES; Subject Term: CANCER treatment; Author-Supplied Keyword: Carcinoma cell lines; Author-Supplied Keyword: Cisplatin; Author-Supplied Keyword: Cytochalasin B; Author-Supplied Keyword: Electron spin resonance; Author-Supplied Keyword: Microfilaments; Author-Supplied Keyword: MicroWlaments; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s00280-008-0687-9
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34284320&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilson, C. A.
T1 - Endogenous retroviruses.
JO - Cellular & Molecular Life Sciences
JF - Cellular & Molecular Life Sciences
Y1 - 2008/11//
VL - 65
IS - 21
M3 - Article
SP - 3399
EP - 3412
SN - 1420682X
AB - Xenotransplantation is defined by the PHS as any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs (Public Health Service Guideline on Infectious Disease Issues in Xenotransplantation). Use of pigs for human xenotransplantation raises concerns about the risks of transfer of infectious agents from the pig cells to xenotransplantation recipients. The observation that the porcine germline harbors genetic loci encoding porcine endogenous retroviruses (PERVs) that are in some cases infectious for human cells has resulted in renewed scientific interest in PERVs. However, in spite of the past 10 years of investigation, the actual risk for PERV infection, replication, and pathogenic outcome in human recipients of xenotransplantation products is still undefined. (Part of a Multi-author Review) [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular & Molecular Life Sciences is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - CELLS
KW - TISSUES
KW - INFECTION
KW - ANIMAL genetics
KW - endogenous
KW - Porcine
KW - retrovirus
KW - xenotransplantation
N1 - Accession Number: 35077445; Wilson, C. A. 1; Email Address: Carolyn.wilson@fda.hhs.gov; Affiliation: 1: Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissues, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Building 29B, Rm 5NN20, Bethesda, MD 20892, USA; Source Info: Nov2008, Vol. 65 Issue 21, p3399; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: CELLS; Subject Term: TISSUES; Subject Term: INFECTION; Subject Term: ANIMAL genetics; Author-Supplied Keyword: endogenous; Author-Supplied Keyword: Porcine; Author-Supplied Keyword: retrovirus; Author-Supplied Keyword: xenotransplantation; Number of Pages: 14p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1007/s00018-008-8498-z
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Webb, George
AU - Patton, Nanette
T1 - Quality and Cost - It's Not Either/Or: Making the Case With Cost of Quality.
JO - CrossTalk: The Journal of Defense Software Engineering
JF - CrossTalk: The Journal of Defense Software Engineering
Y1 - 2008/11//
VL - 21
IS - 11
M3 - Article
SP - 23
EP - 28
SN - 21601577
AB - Today's organizations must be committed to the continuous pursuit of quality improvement as a requirement for survival. Traditionally, quality and cost have been perceived as a trade-off decision. For this reason, the main purpose and benefit of measuring quality costs has been to demonstrate that improved quality and lower costs go hand-in-hand. Through collection and analysis of these quality costs, improvement is translated into a language management listens to and responds to: money. This article provides tools and techniques to help infuse cost of quality (COQ) concepts into the project team activities to promote quality improvement throughout the full project life cycle. [ABSTRACT FROM AUTHOR]
AB - Copyright of CrossTalk: The Journal of Defense Software Engineering is the property of USAF Software Technology Support Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANIZATION
KW - MANAGEMENT
KW - QUALITY
KW - COST
KW - INDUSTRIAL management
KW - QUALITY control
N1 - Accession Number: 34931040; Webb, George 1; Email Address: nanette.patton@us.army.mil Patton, Nanette 2; Email Address: george.webb@patrick.af.mil; Affiliation: 1: 45th Range Management Squadron, Patrick Air Force Base 2: Office of the Surgeon General; Source Info: Nov2008, Vol. 21 Issue 11, p23; Subject Term: ORGANIZATION; Subject Term: MANAGEMENT; Subject Term: QUALITY; Subject Term: COST; Subject Term: INDUSTRIAL management; Subject Term: QUALITY control; Number of Pages: 6p; Illustrations: 2 Black and White Photographs, 3 Diagrams, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105604878
T1 - Practice tip. Make objects safe for use...Reprinted with permission from OSAP
AU - Casuse E
Y1 - 2008/11//Nov/Dec2008
N1 - Accession Number: 105604878. Language: English. Entry Date: 20090206. Revision Date: 20150711. Publication Type: Journal Article; brief item. Note: For CE see page 32. Journal Subset: Allied Health; Blind Peer Reviewed; Peer Reviewed; USA. Special Interest: Dental Care. NLM UID: 16520250R.
KW - Dental Offices
KW - Disposable Equipment -- Utilization
KW - Occupational Safety
KW - Dental Assistants
KW - Education, Continuing (Credit)
SP - 22
EP - 22
JO - Dental Assistant
JF - Dental Assistant
JA - DENT ASSIST
VL - 77
IS - 6
CY - Chicago, Illinois
PB - American Dental Assistant Association
SN - 1088-3886
AD - Certified Dental Assistant, Indian Health Service (IHS)
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DP - EBSCOhost
DB - rzh
ER -
TY -
AU - Julious, Steven A.1, S.A.Julious@Sheffield.ac.uk
AU - Sue-Jane Wang2
T1 - How Biased Are Indirect Comparisons, Particularly When Comparisons Are Made Over Time in Controlled Trials?
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2008/11//
Y1 - 2008/11//
VL - 42
IS - 6
CP - 6
M3 - Article
SP - 625
EP - 633
SN - 00928615
AB - Indirect comparisons are undertaken when a comparison is made between two regimens, usually where the regimens have never been given concurrently in any controlled trial investigating the same general patient population. We highlight the issues of making indirect comparisons when there has been a period of time between the studies, particularly when indirect comparison is being made to placebo. We discuss the impact of any bias in indirectly estimating any effect over placebo in context with noninferiority trials. [ABSTRACT FROM AUTHOR]
KW - Research
KW - Clinical trials
KW - Clinical medicine -- Research
KW - Medical research
KW - Patients
KW - Placebos (Medicine)
KW - Indirect comparisons
KW - Noninferiority
KW - Placebo creep
N1 - Accession Number: 35406676; Authors: Julious, Steven A. 1 Email Address: S.A.Julious@Sheffield.ac.uk; Sue-Jane Wang 2; Affiliations: 1: Medical Statistics Group, Health Services Research, University of Sheffield, Sheffield, England; 2: Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US FDA, Silver Spring, Maryland; Subject: Clinical trials; Subject: Clinical medicine -- Research; Subject: Medical research; Subject: Patients; Subject: Placebos (Medicine); Subject: Research; Author-Supplied Keyword: Indirect comparisons; Author-Supplied Keyword: Noninferiority; Author-Supplied Keyword: Placebo creep; Number of Pages: 9p; Illustrations: 3 Charts, 7 Graphs; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Yamaguchi, Yuji
AU - Coelho, Sergio G.
AU - Zmudzka, Barbara Z.
AU - Takahashi, Kaoruko
AU - Beer, Janusz Z.
AU - Hearing, Vincent J.
AU - Miller, Sharon A.
T1 - Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation.
JO - Experimental Dermatology
JF - Experimental Dermatology
Y1 - 2008/11//
VL - 17
IS - 11
M3 - Article
SP - 916
EP - 924
PB - Wiley-Blackwell
SN - 09066705
AB - Substantial differences in DNA damage caused by a single UV irradiation were found in our previous study on skin with different levels of constitutive pigmentation. In this study, we assessed whether facultative pigmentation induced by repeated UV irradiation is photoprotective. Three sites on the backs of 21 healthy subjects with type II–III skin were irradiated at 100–600 J/m2 every 2–7 days over a 4- to 5-week period. The three sites received different cumulative doses of UV (1900, 2900 or 4200 J/m2) and were biopsied 1 day after the last irradiation. Biomarkers examined included pigment content assessed by Fontana–Masson staining, melanocyte function by expression of melanocyte-specific markers, DNA damage as cyclobutane pyrimidine dimers (CPD), nuclear accumulation of p53, apoptosis determined by TUNEL assay, and levels of p21 and Ser46-phosphorylated p53. Increases in melanocyte function and density, and in levels of apoptosis were similar among the 3 study sites irradiated with different cumulative UV doses. Levels of CPD decreased while the number of p53-positive cells increased as the cumulative dose of UV increased. These results suggest that pigmentation induced in skin by repeated UV irradiation protects against subsequent UV-induced DNA damage but not as effectively as constitutive pigmentation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLOBUTANE
KW - PYRIMIDINES
KW - DIMERS
KW - ULTRAVIOLET radiation
KW - DNA damage
KW - HUMAN skin color
KW - apoptosis
KW - p53
KW - pigmentation
KW - skin cancer
KW - UV
N1 - Accession Number: 34679890; Yamaguchi, Yuji 1; Email Address: hearingv@nih.gov Coelho, Sergio G. 1,2 Zmudzka, Barbara Z. 2 Takahashi, Kaoruko 1 Beer, Janusz Z. 2 Hearing, Vincent J. 1 Miller, Sharon A. 2; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA; Source Info: Nov2008, Vol. 17 Issue 11, p916; Subject Term: CYCLOBUTANE; Subject Term: PYRIMIDINES; Subject Term: DIMERS; Subject Term: ULTRAVIOLET radiation; Subject Term: DNA damage; Subject Term: HUMAN skin color; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: p53; Author-Supplied Keyword: pigmentation; Author-Supplied Keyword: skin cancer; Author-Supplied Keyword: UV; Number of Pages: 9p; Illustrations: 4 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1600-0625.2008.00722.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34679890&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young, Shih-Houng
AU - Antonini, James M.
AU - Roberts, Jenny R.
T1 - SINGLE PRE-EXPOSURE TO A HIGH DOSE OF ZYMOSAN ENHANCES LUNG DEFENSE MECHANISMS AND ACCELERATES THE PULMONARY CLEARANCE OF A BACTERIAL PATHOGEN IN RATS.
JO - Experimental Lung Research
JF - Experimental Lung Research
Y1 - 2008/11//
VL - 34
IS - 9
M3 - Article
SP - 559
EP - 578
PB - Taylor & Francis Ltd
SN - 01902148
AB - The present study examines the effects of pre-exposure to zymosan (a 1 → 3-β -glucan from baker yeast) on lung defense against bacterial infection. Rats received a single dose of zymosan A (0.6, 1.2, or 2.5 mg/kg body weight [bw]) or vehicle control (saline) via intratracheal instillation 3 days prior to intratracheal inoculation with 5 × 105 Listeria monocytogenes. Left lungs were homogenized and cultured to assess bacterial clearance, and bronchoalveolar lavage was performed on the right lungs to monitor lung inflammation and injury. Prior to bacterial infection, zymosan exposure resulted in elevated inflammation and oxidant production in the lungs. Zymosan treatment followed by infection led to an accelerated pulmonary clearance of bacteria when compared to the saline control group in a dose-dependent fashion. In addition, lower levels of injury and inflammation were associated with the enhanced bacteria clearance observed in zymosan-infected rats. Our findings suggest that zymosan exposure may enhance the lung immune response by activating alveolar macrophages prior to infection, and stimulating T cells involved in the adaptive immune response early after infection, thus resulting in a heightened pulmonary immune response. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Lung Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - RESEARCH
KW - ZYMOSAN
KW - LUNGS
KW - DEFENSE reaction (Physiology)
KW - PATHOGENIC microorganisms
KW - RATS
KW - 1 → 3-β-glucans
KW - 1→3-β-glucans
KW - Listeria monocytogenes lung clearance
KW - pulmonary inflammation
KW - zymosan
N1 - Accession Number: 35213135; Young, Shih-Houng 1; Email Address: sby5@cdc.gov Antonini, James M. 1 Roberts, Jenny R. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Source Info: Nov2008, Vol. 34 Issue 9, p559; Subject Term: TOXICOLOGY; Subject Term: RESEARCH; Subject Term: ZYMOSAN; Subject Term: LUNGS; Subject Term: DEFENSE reaction (Physiology); Subject Term: PATHOGENIC microorganisms; Subject Term: RATS; Author-Supplied Keyword: 1 → 3-β-glucans; Author-Supplied Keyword: 1→3-β-glucans; Author-Supplied Keyword: Listeria monocytogenes lung clearance; Author-Supplied Keyword: pulmonary inflammation; Author-Supplied Keyword: zymosan; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 20p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/01902140802372426
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Begley, T. H.
AU - Brandsch, J.
AU - Limm, W.
AU - Siebert, H.
AU - Piringer, O.
T1 - Diffusion behaviour of additives in polypropylene in correlation with polymer properties.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/11//
VL - 25
IS - 11
M3 - Article
SP - 1409
EP - 1415
PB - Taylor & Francis Ltd
SN - 19440049
AB - The migration behaviour of polymer additives in 17 polypropylene (PP) samples is described. These samples cover the major types of PP used in food packaging. The diffusion coefficients of additives with relatively small molecular masses, Mr = 136 (limonene), as well as the migration of typical antioxidants used in PP up to Mr = 1178 (IRGANOX 1010), were measured at different temperatures. In addition, the diffusion data and percentages of xylene-soluble fractions were correlated. This enables a prediction of the migration behaviour of a PP sample by testing its 'isotactic index' with xylene. The results clearly indicate that PP can be subdivided, from the migration point of view, into the monophasic homopolymer (h-PP), the monophasic random copolymer (r-PP), and the heterophasic copolymer (heco-PP). The diffusion coefficients for r-PP are at least one order of magnitude higher than those of h-PP and comparable with the values for heco-PP. Upper limits for the diffusion values can be calculated based on the safety margin required by consumer protection laws. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Packaging
KW - Diffusion
KW - Xylene
KW - Copolymers
KW - Polymers
KW - Polypropylene
KW - Antioxidants
KW - Consumer law
KW - additives general
KW - chromatography
KW - diffusion
KW - food simulants
KW - high-performance liquid chromatography (HPLC)
KW - migration
KW - modelling
KW - packaging
KW - polypropylene
N1 - Accession Number: 35020788; Begley, T. H. 1; Brandsch, J. 2; Limm, W. 1; Siebert, H. 3; Piringer, O. 2; Email Address: otto.piringer@fabes-online.de; Affiliations: 1: US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), College Park, MD, USA; 2: FABES Forschungs-GmbH, Muenchen, Germany; 3: Alkoven/Strassham, Austria; Issue Info: Nov2008, Vol. 25 Issue 11, p1409; Thesaurus Term: Food -- Packaging; Thesaurus Term: Diffusion; Thesaurus Term: Xylene; Thesaurus Term: Copolymers; Subject Term: Polymers; Subject Term: Polypropylene; Subject Term: Antioxidants; Subject Term: Consumer law; Author-Supplied Keyword: additives general; Author-Supplied Keyword: chromatography; Author-Supplied Keyword: diffusion; Author-Supplied Keyword: food simulants; Author-Supplied Keyword: high-performance liquid chromatography (HPLC); Author-Supplied Keyword: migration; Author-Supplied Keyword: modelling; Author-Supplied Keyword: packaging; Author-Supplied Keyword: polypropylene; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 926110 Administration of General Economic Programs; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 313110 Fiber, Yarn, and Thread Mills; NAICS/Industry Codes: 324110 Petroleum Refineries; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/02652030802162747
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zhang, K.
AU - Noonan, G. O.
AU - Begley, T. H.
T1 - Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2008/11//
VL - 25
IS - 11
M3 - Article
SP - 1416
EP - 1423
PB - Taylor & Francis Ltd
SN - 19440049
AB - A gas chromatography-ion-trap tandem mass spectrometry procedure was developed for the determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in domestic and imported paper packages and food sold in US marketplaces. The procedure involved ultrasonic extraction with dichloromethane, followed by analysis with the gas chromatography-ion-trap tandem mass spectrometry. Calibration curves for DIPN and DBP were achieved with concentrations ranging from 0.01 to 10 µg ml-1 and the corresponding r2 values were 0.9976 and 0.9956, respectively. In most of the fortified samples the recoveries were higher than 80% with a relative standard deviation (RSD) <10%. Using this procedure, it was found that less than 20% of the tested domestic packages and more than 60% of the tested imported food packages contained both DIPN and DBP. The concentrations of DIPN and DBP ranged from 0.09 to 20 mg kg-1 and 0.14 to 55 mg kg-1, respectively, with most of the DINP and DBP levels lower than 20 mg kg-1. DIPN was not detected (<0.01 mg kg-1) in 41 food samples and DBP was only detected in two domestic and four imported food samples with concentrations ranging from <0.01 to 0.81 mg kg-1. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Gas chromatography
KW - Naphthalene
KW - Dibutyl phthalate
KW - Extraction (Chemistry)
KW - Tandem mass spectrometry
KW - Food -- Composition
KW - United States
KW - 2,6-diisopropylnaphthalene (DIPN)
KW - dry foods
KW - gas chromatography-ion-trap tandem mass spectrometry (GC-IT-MS/MS)
KW - n-dibutylphthalate (DBP)
KW - paper food package
N1 - Accession Number: 35020787; Zhang, K. 1; Email Address: kai.zhang@fda.hhs.gov; Noonan, G. O. 1; Begley, T. H. 1; Affiliations: 1: US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), MD, USA; Issue Info: Nov2008, Vol. 25 Issue 11, p1416; Thesaurus Term: Gas chromatography; Thesaurus Term: Naphthalene; Thesaurus Term: Dibutyl phthalate; Thesaurus Term: Extraction (Chemistry); Subject Term: Tandem mass spectrometry; Subject Term: Food -- Composition; Subject: United States; Author-Supplied Keyword: 2,6-diisopropylnaphthalene (DIPN); Author-Supplied Keyword: dry foods; Author-Supplied Keyword: gas chromatography-ion-trap tandem mass spectrometry (GC-IT-MS/MS); Author-Supplied Keyword: n-dibutylphthalate (DBP); Author-Supplied Keyword: paper food package; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/02652030802163380
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yuan, Liming
AU - Smith, Alex C.
T1 - Numerical study on effects of coal properties on spontaneous heating in longwall gob areas
JO - Fuel
JF - Fuel
Y1 - 2008/11//
VL - 87
IS - 15/16
M3 - Article
SP - 3409
EP - 3419
SN - 00162361
AB - Abstract: A computational fluid dynamics (CFD) study was conducted to model effects of coal properties on the potential for spontaneous heating in longwall gob (mined-out) areas. A two longwall panel district using a bleeder ventilation system was simulated. The permeability and porosity profiles for the longwall gob were generated from a geotechnical model and were used as inputs for the three-dimensional CFD modeling. The spontaneous heating is modeled as the low-temperature oxidation of coal in the gob using kinetic data obtained from previous laboratory-scale spontaneous combustion studies. Heat generated from coal oxidation is dissipated by convection and conduction, while oxygen and oxidation products are transported by convection and diffusion. Unsteady state simulations were conducted for three different US coals and simulation results were compared with some available test results. The effects of coal surface area and heat of reaction on the spontaneous heating process were also examined. [Copyright &y& Elsevier]
AB - Copyright of Fuel is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VENTILATION
KW - AIR conditioning
KW - POROSITY
KW - OSMOSIS
KW - Coal properties
KW - Mine fires
KW - Mine ventilation
KW - Numerical modeling
KW - Spontaneous heating
N1 - Accession Number: 33529800; Yuan, Liming; Email Address: Lcy6@cdc.gov Smith, Alex C. 1; Affiliation: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, United States; Source Info: Nov2008, Vol. 87 Issue 15/16, p3409; Subject Term: VENTILATION; Subject Term: AIR conditioning; Subject Term: POROSITY; Subject Term: OSMOSIS; Author-Supplied Keyword: Coal properties; Author-Supplied Keyword: Mine fires; Author-Supplied Keyword: Mine ventilation; Author-Supplied Keyword: Numerical modeling; Author-Supplied Keyword: Spontaneous heating; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.fuel.2008.05.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=33529800&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shih, Chuck
AU - Berliner, Elise
T1 - Diffusion Of New Technology And Payment Policies: Coronary Stents.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/11//Nov/Dec2008
VL - 27
IS - 6
M3 - Article
SP - 1566
EP - 1576
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Medicare payment is often cited as a major driver of medical technology diffusion. Stakeholders claimed that beneficiaries would be denied access to stents because Medicare payment did not initially cover the cost of stents. Nevertheless, stents diffused rapidly, including to untested indications. Outcomes with stents improved over time, primarily because of a fundamental property of technology diffusion termed "reinvention," in which new technology is modified by users. The traditional system of regulatory approval and reimbursement does not account for this dynamic process. There has been no incentive for systematic collection of data to determine which modifications are most beneficial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SURGICAL stents
KW - MEDICARE
KW - MEDICAL technology
KW - PROPERTY
KW - MEDICAL care costs
KW - STAKEHOLDERS
KW - MEDICAL care for the aged
KW - DELEGATED legislation
KW - UNITED States
N1 - Accession Number: 36097613; Shih, Chuck 1 Berliner, Elise 2; Email Address: elise.berliner@ahrq.hhs.gov; Affiliation: 1: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore,Maryland. 2: Director, Technology Assessment Program,Center for Outcomes and Evidence,Agency for Healthcare Research and Quality, Rockville.; Source Info: Nov/Dec2008, Vol. 27 Issue 6, p1566; Subject Term: SURGICAL stents; Subject Term: MEDICARE; Subject Term: MEDICAL technology; Subject Term: PROPERTY; Subject Term: MEDICAL care costs; Subject Term: STAKEHOLDERS; Subject Term: MEDICAL care for the aged; Subject Term: DELEGATED legislation; Subject Term: UNITED States; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.27.6.1566
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36097613&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - The Human Genome And Translational Research: How Much Evidence Is Enough?
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/11//Nov/Dec2008
VL - 27
IS - 6
M3 - Article
SP - 1616
EP - 1618
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Multiple new genomic diagnostic tests are currently under development. Given the lack of an efficient translational infrastructure, it is not clear how, or whether, robust evidence for their clinical value will be generated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN genome
KW - HUMAN chromosomes
KW - HUMAN gene mapping
KW - GENOMICS
KW - GENETIC research
KW - MOLECULAR genetics
KW - PUBLIC health
KW - MEDICAL care
N1 - Accession Number: 36097619; Woodcock, Janet 1; Email Address: Janet.woodcock@fda.hhs.gov; Affiliation: 1: Director, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.; Source Info: Nov/Dec2008, Vol. 27 Issue 6, p1616; Subject Term: HUMAN genome; Subject Term: HUMAN chromosomes; Subject Term: HUMAN gene mapping; Subject Term: GENOMICS; Subject Term: GENETIC research; Subject Term: MOLECULAR genetics; Subject Term: PUBLIC health; Subject Term: MEDICAL care; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
L3 - 10.1377/hlthaff.27.6.1616
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36097619&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105601874
T1 - The human genome and translational research: how much evidence is enough?
AU - Woodcock J
Y1 - 2008/11//Nov/Dec2008
N1 - Accession Number: 105601874. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 8303128.
KW - Genetic Research
KW - Genome, Human
KW - Medical Practice, Evidence-Based
KW - Genetic Screening
KW - Genetics
SP - 1616
EP - 1618
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 27
IS - 6
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Multiple new genomic diagnostic tests are currently under development. Given the lack of an efficient translational infrastructure, it is not clear how, or whether, robust evidence for their clinical value will be generated.
SN - 0278-2715
AD - Director, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Janet.woodcock@fda.hhs.gov
U2 - PMID: 18997219.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105601874&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - The Human Genome And Translational Research: How Much Evidence Is Enough?
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/11//Nov/Dec2008
VL - 27
IS - 6
M3 - Article
SP - 1616
EP - 1618
SN - 02782715
AB - Multiple new genomic diagnostic tests are currently under development. Given the lack of an efficient translational infrastructure, it is not clear how, or whether, robust evidence for their clinical value will be generated. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - HUMAN genome
KW - HUMAN chromosomes
KW - HUMAN gene mapping
KW - GENOMICS
KW - GENETIC research
KW - MOLECULAR genetics
KW - PUBLIC health
N1 - Accession Number: 36097619; Woodcock, Janet 1; Email Address: Janet.woodcock@fda.hhs.gov; Affiliations: 1: Director, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.; Issue Info: Nov/Dec2008, Vol. 27 Issue 6, p1616; Thesaurus Term: MEDICAL care; Subject Term: HUMAN genome; Subject Term: HUMAN chromosomes; Subject Term: HUMAN gene mapping; Subject Term: GENOMICS; Subject Term: GENETIC research; Subject Term: MOLECULAR genetics; Subject Term: PUBLIC health; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
L3 - 10.1377/hlthaff.27.6.1616
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=36097619&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105601806
T1 - Go out or stay in? The effects of zero tolerance laws on alcohol use and drinking and driving patterns among college students.
AU - Liang L
AU - Huang J
Y1 - 2008/11//
N1 - Accession Number: 105601806. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Europe; Health Services Administration; Peer Reviewed; UK & Ireland. NLM UID: 9306780.
KW - Alcohol Drinking -- Legislation and Jurisprudence
KW - Ethanol -- Blood
KW - Automobile Driving -- Legislation and Jurisprudence
KW - Students
KW - Accidents, Traffic
KW - Accidents, Traffic -- Prevention and Control
KW - Adolescence
KW - Adult
KW - Alcohol Drinking
KW - Alcohol Drinking -- Epidemiology
KW - Colleges and Universities
KW - Female
KW - Male
KW - United States
SP - 1261
EP - 1275
JO - Health Economics
JF - Health Economics
JA - HEALTH ECON
VL - 17
IS - 11
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AB - Zero tolerance laws make it illegal per se for anyone under age 21 to drive with any measurable amount of blood alcohol. Although a link has been established between zero tolerance laws and lower motor vehicle fatalities, research has not produced strong evidence on how zero tolerance laws influence individual alcohol use and drinking and driving behaviors. Using a unique data set and a difference-in-difference-in-difference-type research design, we are able to analyze a number of pathways through which zero tolerance laws can work among an important underage population, college students. We find that zero tolerance laws reduce drinking and driving among college students. Further analysis of our detailed alcohol use measures suggests that zero tolerance laws are particularly effective at reducing the probability of driving after drinking for those who reported drinking away from home.
SN - 1057-9230
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA; lliang@ahrq.gov
U2 - PMID: 18219708.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105601806&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mettler Jr., Fred A.
AU - Thomadsen, Bruce R.
AU - Bhargavan, Mythreyi
AU - Gilley, Debbie B.
AU - Gray, Joel E.
AU - Lipoti, Jill A.
AU - McCrohan, John
AU - Yoshizumi, Terry T.
AU - Mahesh, Mahadevappa
T1 - MEDICAL RADIATION EXPOSURE IN THE U.S. IN 2006: PRELIMINARY RESULTS.
JO - Health Physics
JF - Health Physics
Y1 - 2008/11//
VL - 95
IS - 5
M3 - Article
SP - 502
EP - 507
SN - 00179078
AB - The article examines medical radiation exposure among the U.S. population in 2006. The National Council on Radiation Protection and Measurements (NCRP) has formed a scientific committee in 2006 to evaluate the current state of knowledge concerning medical radiation exposure. The council's tasks include: estimating the current number and types of medical procedures using ionizing radiation; evaluating the effective dose per procedure as well as annual per capita effective dose and annual collective effective dose; and exploring past and potential future trends.
KW - Radiation exposure
KW - Ionizing radiation
KW - Medical radiology
KW - Associations, institutions, etc.
KW - Radiation -- Safety measures
KW - United States
KW - dose
KW - effective dose
KW - medical radiation
KW - National Council on Radiation Protection and Measurements
KW - population
N1 - Accession Number: 35028955; Mettler Jr., Fred A. 1; Email Address: fmettler@salud.unm.edu; Thomadsen, Bruce R. 2; Bhargavan, Mythreyi 3; Gilley, Debbie B.; Gray, Joel E. 4; Lipoti, Jill A. 5; McCrohan, John 6; Yoshizumi, Terry T. 7; Mahesh, Mahadevappa 8; Affiliations: 1: Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, 1501 San Pedro Blvd SE, Albuquerque, NM 87108; 2: Department of Medical Physics, 1530 Medical Science Center, 1300 University Avenue, University of Wisconsin, Madison, WI 53706; 3: American College of Radiology, 1891 Preston White Drive, Reston, VA 20191; 4: DIQUAD, LLC, 222 Lakeview Court, Steger, IL 60475; 5: New Jersey Department of Environmental Protection, Radiation Protection Programs, P.O. Box 415, Trenton, NJ 08625-0415; 6: CDRH/FDA, U.S. Food and Drug Administration, 9200 Corporate Blvd, Rockville, MD 20850; 7: Duke University School of Medicine, DUMC Box 3155, 2214 Elder Street, Durham, NC 27710; 8: Johns Hopkins Hospital, Department of Radiology, 601 N. Caroline Street, Baltimore, MD 21287-0856; Issue Info: Nov2008, Vol. 95 Issue 5, p502; Thesaurus Term: Radiation exposure; Thesaurus Term: Ionizing radiation; Subject Term: Medical radiology; Subject Term: Associations, institutions, etc.; Subject Term: Radiation -- Safety measures; Subject: United States; Author-Supplied Keyword: dose; Author-Supplied Keyword: effective dose; Author-Supplied Keyword: medical radiation; Author-Supplied Keyword: National Council on Radiation Protection and Measurements; Author-Supplied Keyword: population; NAICS/Industry Codes: 813990 Other Similar Organizations (except Business, Professional, Labor, and Political Organizations); NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 6p; Illustrations: 1 Diagram, 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004.
AU - Cutler, Jeffrey A.
AU - Sorlie, Paul D.
AU - Wolz, Michael
AU - Thom, Thomas
AU - Fields, Larry E.
AU - Roccella, Edward J.
JO - Hypertension (0194911X)
JF - Hypertension (0194911X)
Y1 - 2008/11//
VL - 52
IS - 5
SP - 818
EP - 827
SN - 0194911X
N1 - Accession Number: 35171237; Author: Cutler, Jeffrey A.: 1 Author: Sorlie, Paul D.: 1 email: sorliep@mail.nih.gov. Author: Wolz, Michael: 1 Author: Thom, Thomas: 1 Author: Fields, Larry E.: 2 Author: Roccella, Edward J.: 1 ; Author Affiliation: 1 National Heart Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md.: 2 Pfizer, Inc., New York, NY.; No. of Pages: 10; Language: English; Publication Type: journal article; Update Code: 20081121
N2 - This study assesses trends in hypertension prevalence, blood pressure distributions and mean levels, and hypertension awareness, treatment, and control among US adults, age >or=18 years, between the third National Health and Nutrition Examination Survey (1988-1994) and the 1999-2004 National Health and Nutrition Examination Survey, a period of approximately 10 years. The age-standardized prevalence rate increased from 24.4% to 28.9% (P<0.001), with the largest increases among non-Hispanic women. Depending on gender and race/ethnicity, from one fifth to four fifths of the increase could be accounted for by increasing body mass index. Among hypertensive persons, there were modest increases in awareness (P=0.04), from 68.5% to 71.8%. The rate for men increased from 61.6% to 69.3% (P=0.001), whereas the rate for women did not change significantly. Rates remained higher for women than for men, although the difference narrowed considerably. Improvements in treatment and control rates were larger: 53.1% to 61.4% and 26.1% to 35.1%, respectively (both P<0.001). The greatest increases occurred among non-Hispanic white men and non-Hispanic black persons, especially men. Mexican American persons showed improvement in treatment and control rates, but these rates remained the lowest among race/ethnic subgroups (47.4% and 24.3%, respectively). Among all of the race/ethnic groups, women continued to have somewhat better awareness, treatment, and control, except for control rates among non-Hispanic white persons, which became higher in men. Differences between non-Hispanic black and white persons in awareness, treatment, and control were small. These divergent trends may translate into disparate trends in cardiovascular disease morbidity and mortality. ABSTRACT FROM AUTHOR
KW - *HYPERTENSION
KW - *BLOOD pressure
KW - TRENDS
KW - ETHNICITY
KW - UNITED States
KW - blood pressure
KW - hypertension
KW - obesity
KW - surveillance
KW - trends
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=35171237&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - Mechanisms for Attenuation in Cancellous- Bone-Mimicking Phantoms.
JO - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
JF - IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control
Y1 - 2008/11//
VL - 55
IS - 11
M3 - Article
SP - 2418
EP - 2425
SN - 08853010
AB - Broadband ultrasound attenuation (BUA) in cancellous bone is useful for prediction of osteoporotic fracture risk, but its causes are not well understood. To investigate attenuation mechanisms, 9 cancellous-bone-mimicking phantoms containing nylon filaments (simulating bone trabeculae) em- bedded within soft-tissue-mimicking fluid (simulating marrow) were interrogated. The measurements of frequency-dependent attenuation coefficient had 3 separable components: 1) a linear (with frequency) component attributable to absorption in the soft-tissue-mimicking fluid, 2) a quasilinear (with frequency) component, which may include absorption in and longitudinal-shear mode conversion by the nylon filaments, and 3) a non-linear (with frequency) component, which may be attributable to longitudinal-longitudinal scattering by the nylon filaments. The slope of total linear (with frequency) attenuation coefficient (sum of components #1 and #2) versus frequency was found to increase linearly with volume fraction, consistent with reported measurements on cancellous bone. Backscatter coefficient measurements in the 9 phantoms supported the claim that the nonlinear (with frequency) component of attenuation coefficient (component #3) was closely associated with longitudinal-longitudinal scattering. This work represents the first experimental separation of these 3 components of attenuation in cancellous bone-mimicking phantoms. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMAGING systems in medicine
KW - FRACTURES -- Diagnosis
KW - PHANTOMS (Radiology)
KW - BODY composition -- Models
KW - BONES -- Wounds & injuries
N1 - Accession Number: 35108374; Wear, Keith A. 1; Email Address: kaw@cdrh.fda.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD; Source Info: Nov2008, Vol. 55 Issue 11, p2418; Subject Term: IMAGING systems in medicine; Subject Term: FRACTURES -- Diagnosis; Subject Term: PHANTOMS (Radiology); Subject Term: BODY composition -- Models; Subject Term: BONES -- Wounds & injuries; Number of Pages: 8p; Illustrations: 3 Black and White Photographs, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1109/TUFFC.949
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35108374&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kogi, Kazutaka
AU - Hisanaga, Naomi
AU - Araki, Shunichi
T1 - Good Practices in Occupational Safety and Health in the New Era of Globalization.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/11//
VL - 46
IS - 5
M3 - Article
SP - 419
EP - 420
SN - 00198366
AB - The article discusses various reports published within the issue including one by Ichiro Kawachi on the rise in non-standard work arrangements that is often associated with precarious jobs, another paper deals with specific problem areas of occupational safety and health in relation to the globalizing process in different countries and one by Hiroshi Jonai, with focus on the need to develop right-to-know concepts in chemical risk management in Japan.
KW - Industrial safety
KW - Risk management in business
N1 - Accession Number: 35945304; Kogi, Kazutaka 1; Hisanaga, Naomi 2; Araki, Shunichi 3; Affiliations: 1: Institute for Science of Labour, Japan; 2: Aichi University of Education, Japan; 3: National Institute of Occupational Safety and Health, Japan; Issue Info: 2008, Vol. 46 Issue 5, p419; Thesaurus Term: Industrial safety; Subject Term: Risk management in business; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shibata, Nobuyuki
AU - Maeda, Setsuo
T1 - Vibration-isolating Performance of Cotton Work Gloves Based on Newly Issued JIS T8114.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/11//
VL - 46
IS - 5
M3 - Article
SP - 477
EP - 483
SN - 00198366
AB - The article focuses on the study which examines the vibration-isolating performance of cotton work gloves. The mean vibration transmissibility values are measured to evaluate the vibration isolating performance of cotton work gloves. The results suggest that cotton work gloves do not show more vibration-isolating performance. It is suggested that attention must be paid to promote the widespread use of anti-vibration gloves in place of cotton work gloves to reduce exposure to hand-arm vibration.
KW - Cotton
KW - Vibration tests
KW - Gloves
KW - Vibration (Mechanics)
KW - Dynamic testing
KW - Anti-vibration glove
KW - Cotton work glove
KW - ISO10819
KW - JIS T8114
KW - Vibration transmissibility
N1 - Accession Number: 35945313; Shibata, Nobuyuki 1; Maeda, Setsuo 1; Affiliations: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2008, Vol. 46 Issue 5, p477; Thesaurus Term: Cotton; Subject Term: Vibration tests; Subject Term: Gloves; Subject Term: Vibration (Mechanics); Subject Term: Dynamic testing; Author-Supplied Keyword: Anti-vibration glove; Author-Supplied Keyword: Cotton work glove; Author-Supplied Keyword: ISO10819; Author-Supplied Keyword: JIS T8114; Author-Supplied Keyword: Vibration transmissibility; NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 111920 Cotton Farming; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; Number of Pages: 7p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 4 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105572821
T1 - Method for estimating ultraviolet germicidal fluence rates in a hospital room.
AU - Schafer MP
AU - Kujundzic E
AU - Moss CE
AU - Miller SL
Y1 - 2008/11//2008 Nov
N1 - Accession Number: 105572821. Language: English. Entry Date: 20090109. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Grant Information: Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health. NLM UID: 8804099.
KW - Air Microbiology
KW - Patients' Rooms
KW - Ultraviolet Rays
KW - Coefficient Alpha
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Funding Source
KW - In Vitro Studies
KW - Kruskal-Wallis Test
KW - Mann-Whitney U Test
KW - Radiometry
KW - Time Factors
KW - Human
SP - 1042
EP - 1047
JO - Infection Control & Hospital Epidemiology
JF - Infection Control & Hospital Epidemiology
JA - INFECT CONTROL HOSP EPIDEMIOL
VL - 29
IS - 11
PB - Cambridge University Press
AB - BACKGROUND: Upper-room air UV germicidal irradiation (UVGI) is an effective environmental control measure for mitigating the transmission of airborne infections. Many factors influence the efficacy of an upper-room air UVGI system, including the levels and distribution of radiation. The radiation levels experienced by airborne microorganisms can be estimated by measuring the fluence rate, which is the irradiance from all angles that is incident on a small region of space. METHODS: The fluence rate can be estimated by use of a radiometer coupled to a planar detector. Measurements in 4 directions at a single point are taken and summed to estimate the fluence rate at that point. This measurement process is repeated at different sites in the room at a single height. RESULTS: In the upper air of a test room, the UV fluence rate varied at least 3-fold, with the maximum rate occurring in the immediate vicinity of the fixtures containing lamps emitting UV radiation. In the area that would be occupied by the patient and/or healthcare personnel, no significant variation occurred in the UV fluence rate for a designated height. There was no significant statistical difference between measurements obtained by different individuals, by using a different alignment, or during 5 observation periods. Lamp failures were detected on multiple occasions. CONCLUSION: This method is simple, requires no specialized training, and permits regular monitoring of the necessary UV fluence rates needed to sustain the targeted airborne microorganisms' inactivation level. Additionally, this method allowed for the detection of changes in UV fluence rates in the upper air of the simulated hospital room.
SN - 0899-823X
AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1099, USA. mps3@cdc.gov
U2 - PMID: 18844468.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - LuÃs GarcÃa-Marcos Alvarez
AU - Michael Kogan
AU - Antonio Gimeno
AU - Inés Ontoso
AU - Carlos DÃaz
AU - Alberto Pena
AU - Begoña Aurrecoechea
AU - Rosa Monge
AU - Alfredo Quiros
AU - José Garrido
AU - Iñaqui Canflanca
AU - Ãngel Varela
T1 - Climate and prevalence of atopic eczema in 6- to 7-year-old school children in Spain. ISAAC PhASE III.
JO - International Journal of Biometeorology
JF - International Journal of Biometeorology
Y1 - 2008/11//
VL - 52
IS - 8
M3 - Article
SP - 833
EP - 840
SN - 00207128
AB - Abstract  Atopic eczema (AE) is a chronic skin disease. Recent reports indicate that the worldwide prevalence of AE is increasing and that various environmental factors are implicated in its aetiology. Climatic conditions have been related with AE prevalence, and Spain has varying climatic conditions. The aim of this study is to document the possible climatic influence on the prevalence of AE in schoolchildren aged 6â7 years in three different climatic regions in Spain. We conducted a cross-sectional population-based survey of 28,394 schoolchildren aged 6â7 years from 10 Spanish centres in three different climatic regions. The mean participation rate was 76.5%. AE prevalence was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and the Spanish Academy of Dermatology criteria used in Spain to diagnose AE. The data, including annual temperature, precipitation, relative humidity and the annual number of sunny hours per climatic region, were obtained from the Spanish National Institute of Meteorology. Different AE prevalences were found in all three climatic regions studied: Atlantic, 32.9; Mediterranean 28.3; and Continental 31.2 per 100 children studied (pâ [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Biometeorology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATOPIC dermatitis
KW - SKIN -- Inflammation
KW - INFLAMMATION
KW - ACNE
N1 - Accession Number: 34884622; LuÃs GarcÃa-Marcos Alvarez 1 Michael Kogan 2 Antonio Gimeno 3 Inés Ontoso 4 Carlos DÃaz 5 Alberto Pena 6 Begoña Aurrecoechea 7 Rosa Monge 8 Alfredo Quiros 9 José Garrido 10 Iñaqui Canflanca 11 Ãngel Varela 12; Affiliation: 1: University of Murcia Unit of Clinical Research, Cartagena and Department of Paediatrics Murcia Spain 2: HRSA. Maternal and Child Health Bureau Rockville USA 3: Hospital Infantil 12 de Octubre Section of Paediatric Pneumo-Allergy Madrid Spain 4: Public University of Navarre Department of Health Sciences Navarre Spain 5: Hospital of Basurto Department of Paediatrics Bilbao Spain 6: Regional Ministry of Health, Castellón Section of Epidemiology. Centre of Public Health Castellón Spain 7: Health Centre of Otero â Oviedo Oviedo Spain 8: Hospital del Mar Department of Paediatrics Barcelona Spain 9: University of Valladolid Department of Paediatrics Valladolid Spain 10: Hospital Torrecárdenas Department of Paediatrics AlmerÃa Spain 11: Hospital de Donostia Department of Paediatrics San Sebastián Spain 12: Foundation MarÃa José Jove A Coruña Spain; Source Info: Nov2008, Vol. 52 Issue 8, p833; Subject Term: ATOPIC dermatitis; Subject Term: SKIN -- Inflammation; Subject Term: INFLAMMATION; Subject Term: ACNE; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34884622&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hsiao, H.
AU - Simeonov, P.
AU - Pizatella, T.
AU - Stout, N.
AU - McDougall, V.
AU - Weeks, J.
T1 - Extension-ladder safety: Solutions and knowledge gaps
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/11//
VL - 38
IS - 11/12
M3 - Article
SP - 959
EP - 965
SN - 01698141
AB - Abstract: Falls from ladders are the second leading cause for work-related fatalities in the US construction industry. A significant portion of these incidents occurs at building-construction-and-maintenance worksites during the use of extension ladders. This paper presents the results of a critical literature review related to: (1) risk factors associated with falls from extension ladders, (2) practical engineering solutions that may reduce fall-from-extension-ladder incidents, and (3) questions pertaining to ladder safety that remain unanswered. The review results show that the underlying causes of falls involving extension ladders include the ladder-base slipping out, ladders tipping, workers slipping while on ladders or transitioning from a ladder to a surface at height, and mechanical failures. Some engineering control measures are available in the literature; yet, significant knowledge gaps remain. The knowledge-gap analysis identified four actions needed to advance ladder-safety practice: (1) research on visual indicators to assist in setting up ladders at the correct angle, (2) developing and evaluating measures to ease the transition from a ladder to a surface at heights, (3) integrating ladder accessories into a convertible design to ease the carrying, assembling, and storing of multiple accessories, and thus to encourage safe practices, and (4) developing a graphic-oriented practical guide for safe ladder use, maintenance, and mechanical-flaw detection. Relevance to industry: This paper identified knowledge gaps associated with extension-ladder use for advancing ladder-safety interventions. The development and evaluation of ladder-safety innovations will provide the necessary feedback to ladder manufacturers and ladder-standard-setting bodies for design enhancement and will provide workers practical solutions to reduce injury risks associated with extension-ladder use. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Industrial design
KW - Aerial ladders
KW - Construction industry -- Accidents -- United States
KW - Ladders -- Safety measures
KW - Knowledge gap theory (Communication)
KW - United States
KW - Accessory
KW - Construction
KW - Fall prevention
KW - Ladder
KW - Slip
N1 - Accession Number: 35070173; Hsiao, H. 1; Email Address: hxh4@cdc.gov; Simeonov, P. 1; Pizatella, T. 1; Stout, N. 1; McDougall, V. 2; Weeks, J. 2; Affiliations: 1: Protective Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Advanced Technologies and Laboratories International, Inc., Germantown, MD 20874, USA; Issue Info: Nov2008, Vol. 38 Issue 11/12, p959; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial design; Subject Term: Aerial ladders; Subject Term: Construction industry -- Accidents -- United States; Subject Term: Ladders -- Safety measures; Subject Term: Knowledge gap theory (Communication); Subject: United States; Author-Supplied Keyword: Accessory; Author-Supplied Keyword: Construction; Author-Supplied Keyword: Fall prevention; Author-Supplied Keyword: Ladder; Author-Supplied Keyword: Slip; NAICS/Industry Codes: 416330 Hardware merchant wholesalers; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ergon.2008.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35070173&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hsiao, H.
AU - Simeonov, P.
AU - Pizatella, T.
AU - Stout, N.
AU - McDougall, V.
AU - Weeks, J.
T1 - Extension-ladder safety: Solutions and knowledge gaps
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2008/11//
VL - 38
IS - 11/12
M3 - Article
SP - 959
EP - 965
SN - 01698141
AB - Abstract: Falls from ladders are the second leading cause for work-related fatalities in the US construction industry. A significant portion of these incidents occurs at building-construction-and-maintenance worksites during the use of extension ladders. This paper presents the results of a critical literature review related to: (1) risk factors associated with falls from extension ladders, (2) practical engineering solutions that may reduce fall-from-extension-ladder incidents, and (3) questions pertaining to ladder safety that remain unanswered. The review results show that the underlying causes of falls involving extension ladders include the ladder-base slipping out, ladders tipping, workers slipping while on ladders or transitioning from a ladder to a surface at height, and mechanical failures. Some engineering control measures are available in the literature; yet, significant knowledge gaps remain. The knowledge-gap analysis identified four actions needed to advance ladder-safety practice: (1) research on visual indicators to assist in setting up ladders at the correct angle, (2) developing and evaluating measures to ease the transition from a ladder to a surface at heights, (3) integrating ladder accessories into a convertible design to ease the carrying, assembling, and storing of multiple accessories, and thus to encourage safe practices, and (4) developing a graphic-oriented practical guide for safe ladder use, maintenance, and mechanical-flaw detection. Relevance to industry: This paper identified knowledge gaps associated with extension-ladder use for advancing ladder-safety interventions. The development and evaluation of ladder-safety innovations will provide the necessary feedback to ladder manufacturers and ladder-standard-setting bodies for design enhancement and will provide workers practical solutions to reduce injury risks associated with extension-ladder use. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSTRUCTION industry
KW - INDUSTRIAL safety
KW - INDUSTRIAL design
KW - AERIAL ladders
KW - ACCIDENTS
KW - LADDERS -- Safety measures
KW - KNOWLEDGE gap theory (Communication)
KW - UNITED States
KW - Accessory
KW - Construction
KW - Fall prevention
KW - Ladder
KW - Slip
N1 - Accession Number: 35070173; Hsiao, H. 1; Email Address: hxh4@cdc.gov; Simeonov, P. 1; Pizatella, T. 1; Stout, N. 1; McDougall, V. 2; Weeks, J. 2; Affiliations: 1: Protective Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA; 2: Advanced Technologies and Laboratories International, Inc., Germantown, MD 20874, USA; Issue Info: Nov2008, Vol. 38 Issue 11/12, p959; Thesaurus Term: CONSTRUCTION industry; Thesaurus Term: INDUSTRIAL safety; Thesaurus Term: INDUSTRIAL design; Subject Term: AERIAL ladders; Subject Term: ACCIDENTS; Subject Term: LADDERS -- Safety measures; Subject Term: KNOWLEDGE gap theory (Communication); Subject: UNITED States; Author-Supplied Keyword: Accessory; Author-Supplied Keyword: Construction; Author-Supplied Keyword: Fall prevention; Author-Supplied Keyword: Ladder; Author-Supplied Keyword: Slip; NAICS/Industry Codes: 416330 Hardware merchant wholesalers; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ergon.2008.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=35070173&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Olfert, Jason S.
AU - Kulkarni, Pramod
AU - Wang, Jian
T1 - Measuring aerosol size distributions with the fast integrated mobility spectrometer
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2008/11//
VL - 39
IS - 11
M3 - Article
SP - 940
EP - 956
SN - 00218502
AB - Abstract: A fast integrated mobility spectrometer (FIMS) has been developed for rapid aerosol size distribution measurements including those aerosols with low particle number concentrations. In this work, an inversion routine has been developed for the FIMS and it is demonstrated that the FIMS can accurately measure aerosol size distributions. The inversion routine includes corrections for the particle residence time in the FIMS and other factors related to the width of the response (or transfer) function and multiple charging of particles. Steady-state size distributions measured with the FIMS compared well with those measured by a scanning mobility particle sizer (SMPS). Experiments also show that the FIMS is able to capture the size distribution of rapidly changing aerosol populations. The total particle concentration integrated from distributions measured by the FIMS agrees well with simultaneous measurements by a condensation particle counter (CPC). [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLE size distribution
KW - AEROSOLS (Sprays)
KW - SPECTROMETERS
KW - SPECTRUM analysis
KW - CHEMICAL engineering
KW - ELECTRON mobility
KW - Aerosol size distribution
KW - Electrical mobility
KW - Fast integrated mobility spectrometer
KW - Fast response
N1 - Accession Number: 35074290; Olfert, Jason S. 1 Kulkarni, Pramod 2 Wang, Jian 1; Email Address: jian@bnl.gov; Affiliation: 1: Atmospheric Sciences Division, Brookhaven National Laboratory, Building 815E, Upton, NY 11973, USA 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS: R-5, Cincinnati, OH 45226, USA; Source Info: Nov2008, Vol. 39 Issue 11, p940; Subject Term: PARTICLE size distribution; Subject Term: AEROSOLS (Sprays); Subject Term: SPECTROMETERS; Subject Term: SPECTRUM analysis; Subject Term: CHEMICAL engineering; Subject Term: ELECTRON mobility; Author-Supplied Keyword: Aerosol size distribution; Author-Supplied Keyword: Electrical mobility; Author-Supplied Keyword: Fast integrated mobility spectrometer; Author-Supplied Keyword: Fast response; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; Number of Pages: 17p; Document Type: Article
L3 - 10.1016/j.jaerosci.2008.06.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Verma, Anita
AU - Cheung, Anissa M.
AU - Burns, Drusilla L.
T1 - Stabilization of the Pertussis Toxin Secretion Apparatus by the C Terminus of PtlD.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2008/11//
VL - 190
IS - 21
M3 - Article
SP - 7285
EP - 7290
SN - 00219193
AB - Pertussis toxin (PT) is secreted from Bordetella pertussis by a type IV secretion system, known as the Ptl transporter, that comprises nine different proteins, PtlA to PtlI. In this study, we found that PtlD is required for the stability of three Ptl proteins, PtlE, PtlF, and PtlH. A region limited to the C-terminal 72 amino acids of PtlD (amino acids 392 to 463) was sufficient for maintaining the stability of PtlE, PtlF, and PtlH, although this region was not sufficient to support secretion of the toxin. Further analysis demonstrated that a stretch of 10 amino acids at the C-terminal end of PtlD (amino acids 425 to 434) contributes to transporter stability. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BORDETELLA pertussis
KW - PERTUSSIS toxin
KW - BACTERIAL toxins
KW - BACTERIAL proteins
KW - AMINO acids
KW - BACTERIOLOGY
N1 - Accession Number: 35134410; Verma, Anita 1 Cheung, Anissa M. 1 Burns, Drusilla L. 1; Email Address: drusilla.burns@fda.hhs.gov; Affiliation: 1: Laboratory of Respiratory and Special Pathogens, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Nov2008, Vol. 190 Issue 21, p7285; Subject Term: BORDETELLA pertussis; Subject Term: PERTUSSIS toxin; Subject Term: BACTERIAL toxins; Subject Term: BACTERIAL proteins; Subject Term: AMINO acids; Subject Term: BACTERIOLOGY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1128/JB.01106-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35134410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Keun-Hwa Jung
AU - Kon Chu
AU - Soon-Tae Lee
AU - Hee-Kwon Park
AU - Dong-Hyun Kim
AU - Jin-Hee Kim
AU - Jae-Jun Bahn
AU - Eun-Cheol Song
AU - Manho Kim
AU - Sang Kun Lee
AU - Jae-Kyu Roh
T1 - Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease.
JO - Journal of Cerebral Blood Flow & Metabolism
JF - Journal of Cerebral Blood Flow & Metabolism
Y1 - 2008/11//
VL - 28
IS - 11
M3 - Article
SP - 1795
EP - 1803
SN - 0271678X
AB - Moyamoya disease (MMD) is an unusual form of chronic cerebrovascular occlusive disease that involves the formation of characteristically abnormal vessels. Recent studies have reported that colony-forming unit (CFU) and outgrowth cells represent a subpopulation of endothelial progenitor cells (EPCs). Here, we attempted to determine the significance of CFU number and outgrowth cell yield in MMD. Endothelial progenitor cells were isolated from the blood of 24 adult MMD patients and from 48 age- and risk factor-matched control subjects. After 7 days of culture, CFUs were determined, and yields of outgrowth cells were measured during 2 months of culture. The EPC function was also evaluated using matrigel plate assays. It was found that CFU numbers were significantly lower in MMD patients than in controls. Moreover, during long-term culture, outgrowth cells were isolated from only 10% of control subjects but from 33% of MMD patients, and CFU numbers and tube formation were found to be lower in advanced MMD cases than in those with early stage disease, whereas outgrowth cells were more frequently detected in those with early MMD and moyamoya vessels than in those with advanced disease. These characteristics of circulating EPCs reflect mixed conditions of vascular occlusion and abnormal vasculogenesis during the pathogenesis of MMD.Journal of Cerebral Blood Flow & Metabolism (2008) 28, 1795–1803; doi:10.1038/jcbfm.2008.67; published online 9 July 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cerebral Blood Flow & Metabolism is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOYAMOYA disease
KW - ARTERIAL occlusions
KW - CELLS
KW - CYTOLOGY
KW - BLOOD
KW - colony-forming unit
KW - endothelial progenitor cells
KW - moyamoya disease
KW - outgrowth cells
KW - peripheral blood mononuclear cells
N1 - Accession Number: 34950250; Keun-Hwa Jung 1,2 Kon Chu 1,2 Soon-Tae Lee 1,2,3 Hee-Kwon Park 1,2 Dong-Hyun Kim 1 Jin-Hee Kim 1 Jae-Jun Bahn 1,2 Eun-Cheol Song 2,4 Manho Kim 1,2 Sang Kun Lee 1,2 Jae-Kyu Roh 1,2; Email Address: rohjk@snu.ac.kr; Affiliation: 1: Stroke and Stem Cell Laboratory, Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea 2: Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, South Korea 3: Department of Public Health Service, Seoul National Hospital, Seoul, South Korea 4: Department of Neurology, Inha University Hospital, Incheon, South Korea; Source Info: Nov2008, Vol. 28 Issue 11, p1795; Subject Term: MOYAMOYA disease; Subject Term: ARTERIAL occlusions; Subject Term: CELLS; Subject Term: CYTOLOGY; Subject Term: BLOOD; Author-Supplied Keyword: colony-forming unit; Author-Supplied Keyword: endothelial progenitor cells; Author-Supplied Keyword: moyamoya disease; Author-Supplied Keyword: outgrowth cells; Author-Supplied Keyword: peripheral blood mononuclear cells; Number of Pages: 9p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/jcbfm.2008.67
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boehmer, J. L.
AU - Bannerman, D. D.
AU - Shefcheck, K.
AU - Ward, J. L.
T1 - Proteomic Analysis of Differentially Expressed Proteins in Bovine Milk During Experimentally Induced Escherichia coli Mastitis.
JO - Journal of Dairy Science
JF - Journal of Dairy Science
Y1 - 2008/11//
VL - 91
IS - 11
M3 - Article
SP - 4206
EP - 4218
SN - 00220302
AB - The objectives of the current study were to profile changes in protein composition using 2-dimensional gel electrophoresis on whey samples from a group of 8 cows before and 18 h after infection with Escherichia coli and to identify differentially expressed milk proteins by peptide sequencing using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry post source decay. Only proteins present in whey fractions of all 8 cows were sequenced to avoid reporting a protein response unique to only a subset of infected cows. Despite the overwhelming presence of casein and β-lactoglobulin, the low abundance proteins transthyretin, lactadherin, β-2-microglobulin precursor, α-l-acid glycoprotein, and complement C3 precursor could be identified in whey samples from healthy cows. Whey samples at 18 h postinfection were characterized by an abundance of serum albumin, in spots of varying mass and isoelectric point, as well as increased transthyretin and complement C3 precursor levels. Also detected at 18 h postinoculation were the antimicrobial peptides cathelicidin, indolicidin, and bactenecin 5 and 7, and the proteins β-fibrinogen, α-2-HS-glycoprotein, S100oA12, and α-l-antiproteinase. Most notable was the detection of the acute phase protein α-l-acid glycoprotein in mastitic whey samples, a result not previously reported. In contrast to methods used in previous proteomic analyses of bovine milk, the methods used in the current study enabled the rapid identification of milk proteins with minimal sample preparation. Use of a larger sample size than previous analyses also allowed for more robust protein identification. Results indicate that examination of the protein profile of whey samples from cows after inoculation with E. coli could provide a rapid survey of milk protein modulation during coliform mastitis and aid in the identification of biomarkers of this disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Dairy Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Milk
KW - Escherichia coli infections in animals
KW - Proteomics
KW - Milk proteins
KW - Mastitis
KW - Amino acid sequence
KW - coliform mastitis
KW - milk protein
KW - proteomic analysis
N1 - Accession Number: 35119020; Boehmer, J. L. 1,2; Email Address: jamie.boehmer@fda.hhs.gov; Bannerman, D. D. 3; Shefcheck, K. 4; Ward, J. L. 1; Affiliations: 1: US Food and Drug Administration Center for Veterinary Medicine, Laurel, MD 20708; 2: Department of Animal and Avian Sciences, University of Maryland College Park, 20742; 3: Bovine Functional Genomics Laboratory, USDA-Agricultural Research Service, Beltsville, MD 20705; 4: US Food and Drug Administration Center for Food Safety and Applied Nutrition, College Park, MD; Issue Info: Nov2008, Vol. 91 Issue 11, p4206; Thesaurus Term: Milk; Thesaurus Term: Escherichia coli infections in animals; Subject Term: Proteomics; Subject Term: Milk proteins; Subject Term: Mastitis; Subject Term: Amino acid sequence; Author-Supplied Keyword: coliform mastitis; Author-Supplied Keyword: milk protein; Author-Supplied Keyword: proteomic analysis; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 13p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.3168/jds.2008-1297
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35119020&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Samuel P. Tucker
T1 - Determination of ortho-phthalaldehyde in air and on surfaces.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2008/11//
VL - 10
IS - 11
M3 - Article
SP - 1337
EP - 1349
SN - 14640325
AB - Three sampling and analytical methods have been developed and evaluated for ortho-phthalaldehyde (OPA): (1) an HPLC-UV method for OPA in air, (2) a fluorimetric method for OPA on surfaces, and (3) a colorimetric method for OPA on surfaces. (1) The air sampler contains 350 mg of silica gel coated with 1 mg of acidified 2,4-dinitrophenylhydrazine (DNPH). Air sampling may be conducted at 0.03 to 1.0 L min−1for periods up to 8 h. Samples were eluted with ethyl acetate, and the eluents were allowed to stand for 72 h. Analysis was by high performance liquid chromatography (HPLC) with a UV detector set at 369 nm. An unusual phenomenon was the observation that the stability of the sample on a sampler at 3 °C tends to decrease as the total quantity of OPA collected on the sampler decreases. Elution of the samples within 24 h of air sampling is required. The detection limit (LOD) is approximately 0.02 µg of OPA per sample. OPA on surfaces may be collected with strips cut from a sheet of polyvinyl alcohol (PVA wipe). (2) In the surface wipe method with analysis by fluorescence measurement, the strips of PVA wipe were placed into dimethyl sulfoxide. An aliquot was treated with aqueous N-acetyl-l-cysteine and ethylenediamine. Analysis was performed with a portable fluorometer (excitation and emission wavelengths = 365 nm and 438 nm, respectively). The LOD is 0.2 µg per sample. (3) In the surface wipe method with visual colorimetric detection, the strips of PVA wipe were placed into 30 : 70 acetonitrile : water. An aliquot was treated with N-(1-naphthyl)ethylenediamine in 0.1 msulfuric acid. After color development, the LOD is approximately 48 µg per sample. These methods have been field tested in a hospital. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental monitoring
KW - Ethylenediamine
KW - Aldehydes
KW - High performance liquid chromatography
KW - Fluorimeter
KW - Phenylhydrazine
KW - Polyvinyl alcohol
KW - Wavelengths
N1 - Accession Number: 35045653; Samuel P. Tucker 1; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: Nov2008, Vol. 10 Issue 11, p1337; Thesaurus Term: Environmental monitoring; Thesaurus Term: Ethylenediamine; Subject Term: Aldehydes; Subject Term: High performance liquid chromatography; Subject Term: Fluorimeter; Subject Term: Phenylhydrazine; Subject Term: Polyvinyl alcohol; Subject Term: Wavelengths; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 541620 Environmental Consulting Services; Number of Pages: 13p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rodes, Charles E.
AU - Pellizzari, Edo D.
AU - Dellarco, Michael J.
AU - Erickson, Mitchell D.
AU - Vallero, Daniel A.
AU - Reissman, Dori B.
AU - Lioy, Paul J.
AU - Lippmann, Morton
AU - Burke, Thomas A.
AU - Goldstein, Bernard D.
T1 - ISEA2007 panel: Integration of better exposure characterizations into disaster preparedness for responders and the public.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2008/11//
VL - 18
IS - 6
M3 - Article
SP - 541
EP - 550
PB - Nature Publishing Group
SN - 15590631
AB - An expert panel was convened in October 2007 at the International Society for Exposure Analysis Annual Meeting in Durham, NC, entitled “The Path Forward in Disaster Preparedness Since WTC—Exposure Characterization and Mitigation: Substantial Unfinished Business!” The panel prospectively discussed the critical exposure issues being overlooked during disaster responses and highlighted the needs for an optimal blending of exposure characterizations and hazard controls within disaster settings. The cases were made that effective and timely exposure characterizations must be applied during responses to any disaster, whether terrorist, manmade, or natural in origin. The consistent application of exposure sciences across acute and chronic disaster timelines will assure that the most effective strategies are applied to collect the needed information to guide risk characterization and management approaches. Exposure sciences must be effectively applied across all phases of a disaster (defined as rescue, reentry, recovery, and rehabitation—the four Rs) to appropriately characterize risks and guide risk-mitigation approaches. Failure to adequately characterize and control hazardous exposures increases the likelihood of excess morbidity and mortality. Advancing the infrastructure and the technologies to collect the right exposure information before, during, and immediately after disasters would advance our ability to define risks and protect responders and the public better. The panel provided conclusions, recommendations, and next steps toward effective and timely integration of better exposure science into disaster preparedness, including the need for a subsequent workshop to facilitate this integration. All panel presentations and a summary were uploaded to the ISES1 website (http://www.iseaweb.org/Disaster_Preparedness/index.php).Journal of Exposure Science and Environmental Epidemiology (2008) 18, 541–550; doi:10.1038/jes.2008.42; published online 6 August 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMERGENCY management
KW - HAZARDOUS substances
KW - MANAGEMENT
KW - CRISIS management
KW - DISASTERS
KW - disaster
KW - exposure assessment
KW - personal exposure
N1 - Accession Number: 34851467; Rodes, Charles E. 1; Email Address: charlesr@rti.org Pellizzari, Edo D. 1 Dellarco, Michael J. 2 Erickson, Mitchell D. 3 Vallero, Daniel A. 4 Reissman, Dori B. 5 Lioy, Paul J. 6 Lippmann, Morton 7 Burke, Thomas A. 8 Goldstein, Bernard D. 9; Affiliation: 1: RTI International, P.O. Box 12194, Research Triangle Park, North Carolina, USA 2: National Institute of Children's Health and Development, Bethesda, Maryland, USA 3: Department of Homeland Security, Science and Technology Directorate, Washington, D.C., USA 4: US Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina, USA 5: National Institute for Occupational Safety and Health, CDC, Washington, D.C., USA 6: Environmental and Occupational Health Sciences Institute, RWJMS and Rutgers University UMDNJ, Piscataway, New Jersey, USA 7: New York University Medical Center, Tuxedo, New York, USA 8: Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA 9: University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA; Source Info: Nov2008, Vol. 18 Issue 6, p541; Subject Term: EMERGENCY management; Subject Term: HAZARDOUS substances; Subject Term: MANAGEMENT; Subject Term: CRISIS management; Subject Term: DISASTERS; Author-Supplied Keyword: disaster; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: personal exposure; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 562112 Hazardous Waste Collection; Number of Pages: 10p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1038/jes.2008.42
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murray, Clarence William
AU - Egan, Sara Kathleen
AU - Kim, Henry
AU - Beru, Nega
AU - Bolger, Philip Michael
T1 - US Food and Drug Administration's Total Diet Study: Dietary intake of perchlorate and iodine.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2008/11//
VL - 18
IS - 6
M3 - Article
SP - 571
EP - 580
PB - Nature Publishing Group
SN - 15590631
AB - The US Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) since 1961, which designed to monitor the US food supply for chemical contaminants, nutritional elements, and toxic elements. Recently, perchlorate was analyzed in TDS samples. Perchlorate is used as an oxidizing agent in rocket propellant, is found in other items (e.g., explosives, road flares, fireworks, and car airbags), occurs naturally in some fertilizers, and may be generated under certain climatic conditions. It has been detected in surface and groundwater and in food. Perchlorate at high (e.g., pharmacological) doses can interfere with iodide uptake into the thyroid gland, disrupting its function. The National Academy of Sciences (NAS) has identified that “the fetuses of pregnant women who might have hypothyroidism or iodide deficiency as the most sensitive population.” This study reports on intake estimates of perchlorate and iodine, a precursor to iodide, using the analytical results from the TDS. Estimated average perchlorate and iodine daily intakes as well as the contribution of specific food groups to total intakes were estimated for 14 age/sex subgroups of the US population. The estimated smallest lower bound to the largest upper bound average perchlorate intakes by the 14 age/sex groups range from 0.08 to 0.39 micrograms per kilogram body weight per day (μg/kg bw/day), compared with the US Environmental Protection Agency (EPA) reference dose (RfD) of 0.7 μg/kg bw/day. Infants and children demonstrated the highest estimated intakes of perchlorate on a body weight basis. The estimated average iodine intakes by the 14 age/sex groups reveal a lower bound (ND=0) and upper bound (ND=LOD) range of average intakes from 138 to 353 μg/person/day. Estimated iodine intakes by infants 6–11 months exceed their adequate intake (AI), and intakes by children and adult age/sex groups exceed their relevant estimated average requirement (EAR).Journal of Exposure Science and Environmental Epidemiology (2008) 18, 571–580; doi:10.1038/sj.jes.7500648; published online 2 January 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIET
KW - INGESTION
KW - PERCHLORATES
KW - IODINE
KW - UNITED States
KW - dietary intakes
KW - iodine
KW - monitoring
KW - nutritional element
KW - perchlorate
KW - Total Diet Study
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 34851472; Murray, Clarence William 1; Email Address: Clarence.Murray@fda.hhs.go Egan, Sara Kathleen 1 Kim, Henry 1 Beru, Nega 1 Bolger, Philip Michael 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland, USA; Source Info: Nov2008, Vol. 18 Issue 6, p571; Subject Term: DIET; Subject Term: INGESTION; Subject Term: PERCHLORATES; Subject Term: IODINE; Subject Term: UNITED States; Author-Supplied Keyword: dietary intakes; Author-Supplied Keyword: iodine; Author-Supplied Keyword: monitoring; Author-Supplied Keyword: nutritional element; Author-Supplied Keyword: perchlorate; Author-Supplied Keyword: Total Diet Study; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 9 Charts; Document Type: Article
L3 - 10.1038/sj.jes.7500648
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Day, J. B.
AU - Trujillo, S.
AU - Hao, Y.-Y. D.
AU - Whiting, R. C.
T1 - Thermal Resistance of Francisella tularensis in Infant Formula and Fruit Juices.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/11//
VL - 71
IS - 11
M3 - Article
SP - 2208
EP - 2212
SN - 0362028X
AB - Francisella tularensis is a gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, little information exists on the thermal stability of this organism in food matrices. In the present study, the thermal resistance of the live vaccine strain of F. tularensis in four food products (liquid infant formula, apple juice, mango juice, and orange juice) was investigated. D-values ranged from 12 s (57.5°C) to 580 s (50°C) in infant formula with a z-value of 4.37°C. D-values in apple juice ranged from 8 s (57.5°C) to 59 s (50°C) with a z-value of 9.17°C. The live vaccine strain did not survive at temperatures above 55°C in mango juice and orange juice (>6-log inactivation). D-values at 55 to 47.5°C were 15 to 59 s in mango juice and 16 to 105 s in orange juice with z-values of 9.28 and 12.30°C, respectively. These results indicate that current pasteurization parameters used for destroying common foodborne bacterial pathogens are adequate for eliminating F. tularensis in the four foods tested. This study is the first to determine thermal inactivation of F. tularensis in specific foods and will permit comparisons with the thermal inactivation data of other more traditional foodborne pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - High temperatures
KW - Milk -- Heat treatment
KW - Francisella tularensis
KW - Infant formulas -- Sterilization
KW - Fruit juices -- Pasteurization
N1 - Accession Number: 35519866; Day, J. B. 1; Email Address: james.day@fda.hhs.gov; Trujillo, S. 1; Hao, Y.-Y. D. 1; Whiting, R. C. 1; Affiliations: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Nov2008, Vol. 71 Issue 11, p2208; Thesaurus Term: Food pathogens; Subject Term: High temperatures; Subject Term: Milk -- Heat treatment; Subject Term: Francisella tularensis; Subject Term: Infant formulas -- Sterilization; Subject Term: Fruit juices -- Pasteurization; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; Number of Pages: 5p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ameratunga, Rohan
AU - Ameratunga, Shanthi
AU - Crooks, Christine
AU - Simmons, Greg
T1 - Latex Glove Use by Food Handlers: The Case for Nonlatex Gloves.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/11//
VL - 71
IS - 11
M3 - Article
SP - 2334
EP - 2338
SN - 0362028X
AB - There is increasing concern that continued exposure to latex products can predispose individuals, particularly those who are atopic (allergy prone), to latex allergy. Latex allergy as a serious hazard has been well documented in the health care industry. There are also well-documented cases of food handlers who have had allergic reactions after the use of latex gloves. The contamination of food with latex proteins by food handlers using latex gloves can also result in potentially severe allergic reactions in latex-allergic consumers. We review latex allergy and present the case for avoiding latex glove use by food handlers in the food and hospitality industries. Adopting the use of nonlatex gloves has benefits for workers, consumers, and the food industry. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Food -- Safety measures
KW - Food handling
KW - Latex allergy
KW - Gloves
N1 - Accession Number: 35519886; Ameratunga, Rohan 1; Email Address: rohana@adhb.govt.nz; Ameratunga, Shanthi 2; Crooks, Christine 1; Simmons, Greg 3; Affiliations: 1: LabPlus, P.O. Box 110031, Auckland City Hospital, Park Road, Grafton, Auckland 1148, New Zealand; 2: School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; 3: Auckland Regional Public Health Service, Cornwall Complex, Floor 2, Building 15,. Greenlane Clinical Centre, Private Bag 92605, Symonds Street Auckland 1150, New Zealand; Issue Info: Nov2008, Vol. 71 Issue 11, p2334; Thesaurus Term: Food contamination; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food handling; Subject Term: Latex allergy; Subject Term: Gloves; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; Number of Pages: 5p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yun-Jung Kim
AU - Seung-Hwan Lee
AU - Jiyong Park
AU - Jonghyun Park
AU - Myongsoo Chung
AU - Kisung Kwon
AU - Kyungsook Chung
AU - Misun Won
AU - Kyung Bin Song
T1 - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes on Stored Iceberg Lettuce by Aqueous Chlorine Dioxide Treatment.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2008/11//
VL - 73
IS - 9
M3 - Article
SP - M418
EP - M422
SN - 00221147
AB - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes in iceberg lettuce by aqueous chlorine dioxide (ClO2) treatment was evaluated. Iceberg lettuce samples were inoculated with approximately 7 log CFU/g of E. coli O157:H7, S. typhimurium, and L. monocytogenes. Iceberg lettuce samples were then treated with 0, 5, 10, or 50 ppm ClO2 solution and stored at 4 °C. Aqueous ClO2 treatment significantly decreased the populations of pathogenic bacteria on shredded lettuce ( P < 0.05). In particular, 50 ppm ClO2 treatment reduced E. coli O157:H7, S. typhimurium, and L. monocytogenes by 1.44, 1.95, and 1.20 log CFU/g, respectively. The D10-values of E. coli O157:H7, S. typhimurium, and L. monocytogenes in shredded lettuce were 11, 26, and 42 ppm, respectively. The effect of aqueous ClO2 treatment on the growth of pathogenic bacteria during storage was evaluated, and a decrease in the population size of these pathogenic bacteria was observed. Additionally, aqueous ClO2 treatment did not affect the color of lettuce during storage. These results suggest that aqueous ClO2 treatment can be used to improve the microbial safety of shredded lettuce during storage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LETTUCE
KW - ESCHERICHIA coli
KW - SALMONELLA typhimurium
KW - LISTERIA monocytogenes
KW - CHLORINE dioxide
KW - MICROBIAL growth
KW - FOOD -- Storage
KW - aqueous chlorine dioxide
KW - D-value
KW - iceberg lettuce
KW - microbial growth
KW - storage
N1 - Accession Number: 35037644; Yun-Jung Kim 1 Seung-Hwan Lee 1 Jiyong Park 2 Jonghyun Park 3 Myongsoo Chung 4 Kisung Kwon 5 Kyungsook Chung 6 Misun Won 6 Kyung Bin Song 1; Email Address: kbsong@cnu.ac.kr; Affiliation: 1: Dept. of Food Science and Technology, Chungnam National Univ., Daejeon, 305-764, Korea 2: Dept. of Biotechnology, Yonsei Univ., Seoul, 120-749, Korea 3: Dept. of Food Science and Biotechnology, Kyungwon Univ., Sungnam, 461-701, Korea 4: Dept. of Food Science, Ehwa Women's Univ., Seoul, 120-750, Korea 5: Center for Food Safety Evaluation, Korea Food and Drug Administration, Seoul, 122-704, Korea 6: Korea Research Inst. of Bioscience and Biotechnology, Daejeon, 305-806, Korea; Source Info: Nov2008, Vol. 73 Issue 9, pM418; Subject Term: LETTUCE; Subject Term: ESCHERICHIA coli; Subject Term: SALMONELLA typhimurium; Subject Term: LISTERIA monocytogenes; Subject Term: CHLORINE dioxide; Subject Term: MICROBIAL growth; Subject Term: FOOD -- Storage; Author-Supplied Keyword: aqueous chlorine dioxide; Author-Supplied Keyword: D-value; Author-Supplied Keyword: iceberg lettuce; Author-Supplied Keyword: microbial growth; Author-Supplied Keyword: storage; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1750-3841.2008.00940.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rios, M.
AU - Daniel, S.
AU - Dayton, A. I.
AU - Wood, O.
AU - Hewlett, I. K.
AU - Epstein, J. S.
AU - Caglioti, S.
AU - Stramer, S. L.
T1 - In Vitro Evaluation of the Protective Role of Human Antibodies to West Nile Virus (WNV) Produced during Natural WNV Infection.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2008/11//11/1/2008
VL - 198
IS - 9
M3 - Article
SP - 1300
EP - 1308
SN - 00221899
AB - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious. Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs). Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody-positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious. Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - KILLER cells
KW - GLOBULINS
KW - BLOOD proteins
KW - ANTIGENS
KW - ANTITOXINS
KW - AUTOANTIBODIES
KW - RNA
KW - UNITED States
N1 - Accession Number: 35134364; Rios, M. 1; Email Address: Maria.Rios@fda.hhs.gov Daniel, S. 1 Dayton, A. I. 1 Wood, O. 1 Hewlett, I. K. 1 Epstein, J. S. 1 Caglioti, S. 2 Stramer, S. L. 3; Affiliation: 1: Laboratory of Molecular Virology"Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda 2: Blood Systems Laboratories, Tempe, Arizona 3: American Red Cross, Gaithersburg, Maryland; Source Info: 11/1/2008, Vol. 198 Issue 9, p1300; Subject Term: IMMUNOGLOBULINS; Subject Term: KILLER cells; Subject Term: GLOBULINS; Subject Term: BLOOD proteins; Subject Term: ANTIGENS; Subject Term: ANTITOXINS; Subject Term: AUTOANTIBODIES; Subject Term: RNA; Subject Term: UNITED States; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: Article
L3 - 10.1086/592277
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105565676
T1 - In vitro evaluation of the protective role of human antibodies to West Nile Virus (WNV) produced during natural WNV infection.
AU - Rios M
AU - Daniel S
AU - Dayton AI
AU - Wood O
AU - Hewlett IK
AU - Epstein JS
AU - Caglioti S
AU - Stramer SL
Y1 - 2008/11//11/1/2008
N1 - Accession Number: 105565676. Language: English. Entry Date: 20090123. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Commentary: Katz LM. Transfusion safety in the 21st Century: how tightly should the blood community close the window(s)? (J INFECT DIS) 11/1/2008; 198 (9): 1258-1261. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Grant Information: Center for Biologics Evaluation and Research, Food and Drug Administration. NLM UID: 0413675.
KW - Antibodies, Viral -- Blood
KW - Antibodies, Viral -- Immunology
KW - Flavivirus -- Immunology
KW - West Nile Fever -- Immunology
KW - Chi Square Test
KW - Descriptive Statistics
KW - Experimental Studies
KW - Fisher's Exact Test
KW - Funding Source
KW - In Vitro Studies
KW - RNA -- Blood
KW - Tissue Culture Techniques
KW - Viral Load
KW - Human
SP - 1300
EP - 1308
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 198
IS - 9
PB - Oxford University Press / USA
AB - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious.Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs).Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody-positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious.Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation. © 2008 by the Infectious Diseases Society of America. All rights reserved.
SN - 0022-1899
AD - Laboratory of Molecular Virology--Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD
U2 - PMID: 18771407.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105599661
T1 - Does tonsillectomy lead to improved outcomes over and above the effect of time? A longitudinal study.
AU - Fox R
AU - Temple M
AU - Owens D
AU - Short A
AU - Tomkinson A
Y1 - 2008/11//
N1 - Accession Number: 105599661. Language: English. Entry Date: 20090123. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 8706896.
KW - Surgery, Otorhinolaryngologic -- Methods
KW - Tonsillectomy -- Statistics and Numerical Data
KW - Tonsillitis -- Epidemiology
KW - Adult
KW - Child
KW - Data Analysis Software
KW - Female
KW - Male
KW - Morbidity
KW - Prospective Studies
KW - Questionnaires
KW - Treatment Outcomes
KW - Human
SP - 1197
EP - 1200
JO - Journal of Laryngology & Otology
JF - Journal of Laryngology & Otology
JA - J LARYNGOL OTOL
VL - 122
IS - 11
PB - Cambridge University Press
SN - 0022-2151
AD - Screening Services, Velindre NHS Trust, Cardiff, Infection and Comunicable Disease Service (ICDS), National Public Health Service for Wales, Cardiff; rosemary.fox@velindre-tr.wales.nhs.uk
U2 - PMID: 18267043.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Macher, Janet
AU - Chen, Bean
AU - Rao, Carol
T1 - Chamber Evaluation of a Personal, Bioaerosol Cyclone Sampler.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/11//
VL - 5
IS - 11
M3 - Article
SP - 702
EP - 712
PB - Taylor & Francis Ltd
SN - 15459624
AB - A personal cyclone sampler (cyclone) was operated in a 0.9-m3 chamber, side by side with a 25-mm filter sampler (filter) and either a slit impactor (Air-O-Cell) or a single-stage, multiple-hole, agar impactor (N6). Aerosols of two fungal spores were collected for 5 min to 5 hr—Aspergillus versicolor: 10, 20, 40, 80, 160, and 320 min; concentration: 102-105 spore m-3; Scopulariopsis brevicaulis: 5, 10, 15, 20, 25, and 30-min; concentration: 103-105 spore m-3 (six replicates for each sampling time). For each fungus, air concentrations were determined by a 15-channel optical particle counter (particle m-3; N = 36), microscopy (spore m-3; cyclone and filter, N = 36; Air-O-Cell, N = 18), culture (colony forming unit m-3; cyclone and filter, N = 36; N6, N = 18), and polymerase chain reaction (cell equivalent m-3; cyclone and filter, N = 36). Samplers were significantly correlated with each other as were the three analyses (correlation coefficients = 0.79-1.00 and 0.87-0.98, respectively). Ratios were calculated for simultaneous measurements with the cyclone and comparison samplers and for paired colony:spore, colony:cell equivalent, and cell equivalent:spore measurements for the cyclone and filter samples. The cyclone equaled or underestimated the other samplers for both fungi and all analyses (mean ratio: 0.75-1.04). A. versicolor colony and cell equivalent measurements exceeded spore measurements although microscopy should detect all spores not just culturable ones, perhaps due to difficulty observing the smaller spores or detection of DNA in cell fragments in addition to intact spores. Plots of the ratios of paired measurements against their averages identified biases between samplers and analyses. For example, ratios were correlated with spore concentration, and there was greater uncertainty at lower concentrations. These chamber tests have shown that the cyclone is suitable for collection of airborne fungal spores over a wide concentration range and time period and for analysis by microscopy, culture, and polymerase chain reaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Algae
KW - Polysaccharides
KW - Aerosols (Sprays)
KW - Fungi
KW - Microscopy
KW - Polymerase chain reaction
KW - Aspergillus
KW - DNA
KW - Genes
KW - airborne fungal spores
KW - chamber study
KW - cyclone sampler
KW - method comparison
KW - sampler performance
N1 - Accession Number: 34192537; Macher, Janet 1; Email Address: janet.macher@cdph.ca.gov.; Chen, Bean 2; Rao, Carol 3; Affiliations: 1: California Department of Public Health, Environmental Health Laboratory, Richmond, California; 2: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia; 3: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Nov2008, Vol. 5 Issue 11, p702; Thesaurus Term: Algae; Thesaurus Term: Polysaccharides; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Fungi; Subject Term: Microscopy; Subject Term: Polymerase chain reaction; Subject Term: Aspergillus; Subject Term: DNA; Subject Term: Genes; Author-Supplied Keyword: airborne fungal spores; Author-Supplied Keyword: chamber study; Author-Supplied Keyword: cyclone sampler; Author-Supplied Keyword: method comparison; Author-Supplied Keyword: sampler performance; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112519 Other Aquaculture; Number of Pages: 11p; Illustrations: 1 Black and White Photograph, 4 Diagrams, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620802380351
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34192537&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Macher, Janet
AU - Chen, Bean
AU - Rao, Carol
T1 - Field Evaluation of a Personal, Bioaerosol Cyclone Sampler.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/11//
VL - 5
IS - 11
M3 - Article
SP - 724
EP - 734
PB - Taylor & Francis Ltd
SN - 15459624
AB - A personal cyclone sampler (cyclone) was operated continuously alongside a 25-mm filter sampler (filter), a slit impactor (Burkard slide), and a high-volume cyclone sampler (Burkard cyclone) at an outdoor location with abundant naturally occurring fungi (N = 30; sampling time: 12.5 ± 2.3 hr). Air concentrations (spore m-3) of 28 fungal groups were determined for all samplers by microscopy. Cyclone performance was judged using various indices to determine if it agreed with the other samplers in determination of the frequencies with which the fungal groups were observed, as well as their proportions of the total air concentration. Fungal diversity estimates were similar for all samplers and in the range of what has been reported nationally, i.e., observation of 9-11 equal groups per sample, but spore concentration dominated by 2-3 groups. Plots of paired cyclone:comparison sampler ratios against average concentrations identified biases. For example, ratios were correlated with concentration and there was greater uncertainty at lower concentrations. Mean ratios for cyclone:filter comparisons were not significantly different from one for ascospores, Aspergillus-Penicillium spp., basidiospores, Cladosporium spp., or total spore m-3. However, agreement was less consistent with the Burkard slide (0.74, 1.12, 0.91, 1.09, and 0.92, respectively) and the Burkard cyclone (2.31, 1.62, 1.43, 1.91, and 1.33, respectively). Concentrations of cell equivalent m-3 also were determined for the filter and two cyclone samples by polymerase chain reaction. Cell equivalents for Aspergillus fumigatus and Penicillium brevicompactum were compared with Aspergillus-Penicillium spp. spores, and Cladosporium cladosporioides and Cladosporium herbarum cell equivalents were compared with Cladosporium spp. spores. Cell equivalent:spore ratios below one for A. fumigatus and P. brevicompactum indicated that these species comprised smaller factions of total spores or were collected less efficiently than the larger C. cladosporioides and C. herbarum spores. The personal cyclone was shown to be suitable for collection of ambient airborne fungal spores and for analysis by microscopy and polymerase chain reaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fungi
KW - Biodiversity
KW - Air analysis
KW - Air sampling apparatus
KW - Spores
KW - Microscopy
KW - cyclone sampler
KW - fungal biodiversity
KW - method comparison
KW - outdoor air
KW - sampler performance
N1 - Accession Number: 36386588; Macher, Janet 1; Email Address: janet.macher@cdph.ca.gov; Chen, Bean 2; Rao, Carol 3; Affiliations: 1: California Department of Public Health, Environmental Health Laboratory, Richmond, California; 2: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia; 3: National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia; Issue Info: Nov2008, Vol. 5 Issue 11, p724; Thesaurus Term: Fungi; Thesaurus Term: Biodiversity; Thesaurus Term: Air analysis; Subject Term: Air sampling apparatus; Subject Term: Spores; Subject Term: Microscopy; Author-Supplied Keyword: cyclone sampler; Author-Supplied Keyword: fungal biodiversity; Author-Supplied Keyword: method comparison; Author-Supplied Keyword: outdoor air; Author-Supplied Keyword: sampler performance; Number of Pages: 11p; Illustrations: 1 Diagram, 6 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105554244
T1 - Engineering case reports.
AU - Old L
AU - Dunn KH
AU - Garcia A
AU - Echt A
Y1 - 2008/11//
N1 - Accession Number: 105554244. Language: English. Entry Date: 20090109. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Flavoring Agents
KW - Food Handling
KW - Occupational Exposure -- Prevention and Control
KW - Ventilation -- Equipment and Supplies
KW - Ventilation -- Standards
KW - Human
SP - D103
EP - 10
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio
U2 - PMID: 18770075.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105554246
T1 - Analytical performance criteria.
AU - Ashley K
AU - McKernan LT
AU - Burroughs E
AU - Deddens J
AU - Pendergrass S
AU - Streicher RP
Y1 - 2008/11//
N1 - Accession Number: 105554246. Language: English. Entry Date: 20090109. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Environmental Monitoring -- Methods
KW - Ketones -- Analysis
KW - Occupational Exposure -- Analysis
KW - Comparative Studies
KW - Environmental Monitoring -- Standards
KW - Evaluation Research
KW - Humidity
KW - National Institute for Occupational Safety and Health
KW - United States
KW - Human
SP - D111
EP - 6
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 11
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio
U2 - PMID: 18726763.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105446184
T1 - Integration of viral hepatitis services into opioid treatment programs.
AU - Kresina TF
AU - Bruce RD
AU - Lubran R
AU - Clark HW
Y1 - 2008/11//2008 Nov-Dec
N1 - Accession Number: 105446184. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101234523.
KW - Hepatitis, Viral, Human -- Complications
KW - Mental Disorders -- Complications
KW - Methadone -- Therapeutic Use
KW - Narcotics -- Therapeutic Use
KW - Substance Use Disorders -- Complications
KW - Substance Use Disorders -- Rehabilitation
KW - Substance Use Rehabilitation Programs -- Administration
KW - Adult
KW - Hepatitis, Viral, Human -- Drug Therapy
KW - Patient Education
KW - Substance Use Rehabilitation Programs -- Statistics and Numerical Data
KW - United States
SP - 369
EP - 381
JO - Journal of Opioid Management
JF - Journal of Opioid Management
JA - J OPIOID MANAGE
VL - 4
IS - 6
CY - Weston, Massachusetts
PB - Weston Medical Publishing, LLC
SN - 1551-7489
AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA.
U2 - PMID: 19192765.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wear, Keith A.
AU - Harris, Gerald R.
T1 - Frequency dependence of backscatter from thin, oblique, finite-length cylinders measured with a focused transducer-with applications in cancellous bone.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/11//
VL - 124
IS - 5
M3 - Article
SP - 3309
EP - 3314
SN - 00014966
AB - A model is presented for the echo from a thin, oblique, finite-length cylinder. The echo is calculated from the line integral of the transducer directivity pattern along the cylinder axis. The model was validated with broadband pulse-echo measurements from (1) a perpendicular (to the ultrasound beam) nylon wire as a function of lateral displacement from the beam center, (2) a tilted nylon wire as a function of the angle of inclination relative to the ultrasound beam, and (3) a quasi-parallel-nylon-wire phantom, which mimicked the scattering properties of cancellous bone. The transducer directivity pattern (as a function of position and frequency) was measured with a membrane hydrophone. The model predicts an approximately cubic frequency dependence of backscatter coefficient from the phantom, as has been observed experimentally in cancellous bone. The model also predicts the relationship between the cylinder length and the exponent of a power law fit to backscatter coefficient versus frequency, which is 4 for very short (compared to a wavelength) cylinders and asymptotically approaches 3 for very long cylinders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ECHO
KW - ACOUSTIC phenomena in nature
KW - SOUND reverberation
KW - CYLINDERS (Engines)
KW - TRANSDUCERS
KW - AUDIO frequency
N1 - Accession Number: 35168267; Wear, Keith A. 1; Email Address: kaw@fda.hhs.gov Harris, Gerald R. 1; Affiliation: 1: U. S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland 20993; Source Info: Nov2008, Vol. 124 Issue 5, p3309; Subject Term: ECHO; Subject Term: ACOUSTIC phenomena in nature; Subject Term: SOUND reverberation; Subject Term: CYLINDERS (Engines); Subject Term: TRANSDUCERS; Subject Term: AUDIO frequency; NAICS/Industry Codes: 333995 Fluid Power Cylinder and Actuator Manufacturing; NAICS/Industry Codes: 334419 Other Electronic Component Manufacturing; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; Number of Pages: 6p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1121/1.2980524
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marsteller, Jill A.
AU - Tiggle, Ronald B.
AU - Remsburg, Robin E.
AU - Bardenheier, Barbara
AU - Shefer, Abigail
AU - Han, Beth
T1 - Pneumococcal Vaccination in Nursing Homes: Does Race Make a Difference?
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
Y1 - 2008/11//
VL - 9
IS - 9
M3 - Article
SP - 641
EP - 647
SN - 15258610
AB - Objectives: Known disparities in pneumococcal vaccination in the community raise the question of whether disparities also exist in the nursing home setting, which is better controlled. This study used nationally representative nursing home data to compare black and white nursing home residents with respect to receiving, not receiving, or having an unknown PPV vaccination status, and to examine the interaction of race with various facility characteristics. Design: Multinomial logistic regression was used to analyze a 2-year merged file (1997 and 1999) of the National Nursing Home Survey, a cross-sectional national probability sample of nursing homes and residents. Setting and Participants: Residents 65 years or older (n = 14,782) residing in nursing homes between July and December of 1997 or 1999. Measurements: Record-based staff report of whether residents ever had a pneumococcal immunization (yes/no/unknown); race measured as black or white. Results: Pneumococcal vaccination rates are lower for black nursing home residents than for white residents, as shown using a merged file of the 1997 and 1999 National Nursing Home Surveys. Participants include 14,303 randomly sampled residents 65 years or older. In this sample, 31% of black residents compared with 24% of white residents 65 years or older had never received pneumococcal vaccination (P < .01). Multivariate logistic regression confirmed that blacks were more likely to be unimmunized than whites (95% CIs), specifically in Medicaid-only facilities and dually certified Medicare and Medicaid facilities. Blacks also had higher odds of unknown vaccination status than whites in Medicaid-only facilities and lower odds of unknown status in government-owned facilities. Conclusions: Results suggest that the racial difference in pneumococcal vaccination exists predominantly in certain facility types. In addition, facility-based interventions such as having an organized PPV immunization program or improving documentation of vaccination status can be effective in increasing vaccination rates for all races. [Copyright &y& Elsevier]
AB - Copyright of Journal of the American Medical Directors Association is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PNEUMOCOCCAL vaccine
KW - NURSING home care
KW - RACIAL differences
KW - RESIDENTS (Medicine)
KW - LOGISTIC regression analysis
KW - CROSS-sectional method
KW - IMMUNIZATION
KW - nursing homes
KW - pneumococcal disease
KW - race
KW - Vaccination
N1 - Accession Number: 35075233; Marsteller, Jill A. 1,2; Email Address: ble2@cdc.gov Tiggle, Ronald B. 1 Remsburg, Robin E. 1 Bardenheier, Barbara 3 Shefer, Abigail 3 Han, Beth 4; Affiliation: 1: Long-term Care Statistics Branch, Division of Health Care Statistics, National Center Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 2: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 3: Vaccination Services Division, National Vaccination Program, Centers for Disease Control and Prevention, Atlanta, GA 4: Substance Abuse and Mental Health Services Administration, Department of Health and Human Services, Rockville, MD; Source Info: Nov2008, Vol. 9 Issue 9, p641; Subject Term: PNEUMOCOCCAL vaccine; Subject Term: NURSING home care; Subject Term: RACIAL differences; Subject Term: RESIDENTS (Medicine); Subject Term: LOGISTIC regression analysis; Subject Term: CROSS-sectional method; Subject Term: IMMUNIZATION; Author-Supplied Keyword: nursing homes; Author-Supplied Keyword: pneumococcal disease; Author-Supplied Keyword: race; Author-Supplied Keyword: Vaccination; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jamda.2008.03.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kim, Hee-Yeon
AU - Kwak, In-Shin
AU - Hwang, In-Gyun
AU - Ko, GwangPyo
T1 - Optimization of methods for detecting norovirus on various fruit
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008/11//
VL - 153
IS - 2
M3 - Article
SP - 104
EP - 110
SN - 01660934
AB - Abstract: Methods for detecting norovirus (NoV) in food are crucial for investigation and prevention of outbreaks caused by NoV-contaminated food. However, current NoV detection methods have not been well examined or optimized. In this study, the effectiveness of various methods for eluting NoV from various fruit, concentrating the virus using polyethylene glycol (PEG), and extracting the viral RNA for subsequent assay by RT-PCR was optimized. First, six different buffers previously described for eluting NoV from fruit surfaces were evaluated. A known amount of NoV was spiked onto the surface of grapes, strawberries, and raspberries, and the virus was recovered with distilled water, 0.05M glycine–0.14M NaCl (pH 7.5), 2.9% tryptose phosphate broth–6% glycine, 100mM Tris–HCl (pH 9.5), 50mM glycine–50mM MgCl2 (pH 9.5), or 3% beef extract. Quantitation of the recovered virus using RT-PCR revealed that the most effective elution buffer was 3% beef extract. Secondly, to optimize a method for concentrating the recovered NoV, the key parameters of PEG precipitation, a typical method for concentrating enteric virus, were investigated. The influence of PEG molecular weight and the duration and temperature of the precipitation procedure were examined. NoV was concentrated most efficiently by precipitation when PEG10,000 was used for 4h at room temperature. Finally, five different methods for nucleic acid extraction were evaluated. Among RNA extraction methods examined, QIAamp Viral RNA Mini kit showed the best recovery efficiency. Using the optimized method, approximately 6–80% of the seeded NoV was recovered from the various fruit. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOROVIRUSES
KW - COMMUNICABLE diseases -- Prevention
KW - POLYETHYLENE glycol
KW - RNA
KW - Elution
KW - Fruit
KW - Gastroenteritis
KW - Norovirus
KW - Nucleic acid extraction
KW - PEG concentration
N1 - Accession Number: 34648067; Kim, Hee-Yeon 1 Kwak, In-Shin 2 Hwang, In-Gyun 2 Ko, GwangPyo 1,3; Email Address: gko@snu.ac.kr; Affiliation: 1: Department of Environmental Health and Institute of Health and Environment, School of Public Health, Seoul National University, Seoul, South Korea 2: Division of Food Microbiology, Department of Food Safety Evaluation, Korea Food and Drug Administration, Seoul, South Korea 3: Institute of Microbiology, School of Biological Sciences, Seoul National University, Seoul, South Korea; Source Info: Nov2008, Vol. 153 Issue 2, p104; Subject Term: NOROVIRUSES; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: POLYETHYLENE glycol; Subject Term: RNA; Author-Supplied Keyword: Elution; Author-Supplied Keyword: Fruit; Author-Supplied Keyword: Gastroenteritis; Author-Supplied Keyword: Norovirus; Author-Supplied Keyword: Nucleic acid extraction; Author-Supplied Keyword: PEG concentration; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jviromet.2008.07.022
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Wei
AU - Butler, Eboneé N.
AU - Veguilla, Vic
AU - Vassell, Russell
AU - Terrig Thomas, J.
AU - Moos, Malcolm
AU - Ye, Zhiping
AU - Hancock, Kathy
AU - Weiss, Carol D.
T1 - Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008/11//
VL - 153
IS - 2
M3 - Article
SP - 111
EP - 119
SN - 01660934
AB - Abstract: Pseudotype reporter viruses provide a safe, quantitative, and high-throughput tool for assessing antibody neutralization for many viruses, including high pathogenicity H5 and H7 influenza A strains. However, adapting this system to other influenza subtypes has been hampered by variations in the protease cleavage site of hemagglutinin (HA) that make it less susceptible to the cleavage required for infectivity. In this report several proteases, reporter vectors, and cell substrates were evaluated while optimizing pseudovirus production, and robust methods were established for sensitive and specific neutralization of pseudotypes carrying influenza H1, H3, and H5 subtype HA that correlates well with titers obtained in microneutralization assays involving replicating influenza virus These findings should facilitate broad use of HA-pseudotypes that remove the need for infectious virus in a range of applications, including neutralization assays for serological surveys of viral infection and evaluations of vaccine sera. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - NEUTRALIZATION (Chemistry)
KW - INFLUENZA A virus
KW - IMMUNOGLOBULINS
KW - β-galactosidase ( β-gal )
KW - A/Aichi/2/1968 ( Aichi )
KW - A/Indonesia/5/2005 ( Ind )
KW - A/New Caledonia/20/1999 ( NCD )
KW - A/Puerto Rico/8/1934 ( PR )
KW - A/Shangdong/9/1993 ( SD )
KW - A/Solomon Islands/3/2006 ( SI )
KW - A/South Carolina/1/1918 ( SC )
KW - A/Thailand/1(KAN-1)/2004 ( TL )
KW - A/Thailand/3(SP-83)/2004 ( TL-(SP-83) )
KW - A/Turkey/1/2005 ( Trk )
KW - A/Vietnam/1203/2004 ( VN )
KW - A/Wisconsin/67/2005 ( Wis )
KW - A/Wyoming/3/2003 ( Wyo )
KW - any amino acid ( X )
KW - any basic amino acid ( B )
KW - centers for disease control and prevention ( CDC )
KW - Food and Drug Administration ( FDA )
KW - Hemagglutinin
KW - hemagglutinin ( HA )
KW - Hemagglutinin inhibition
KW - hemagglutinin inhibition ( HAI )
KW - human airway trypsin-like protease ( HAT )
KW - human immunodeficiency virus ( HIV )
KW - Influenza
KW - luciferase ( Luc )
KW - microneutralization ( MN )
KW - murine leukemia virus ( MLV )
KW - national institutes of health ( NIH )
KW - neuraminidase ( NA )
KW - Neutralization
KW - Protease
KW - Pseudotype
KW - serine 2 ( TMPRSS2 )
KW - subtilisin-like proprotein convertase ( SPC )
KW - transmembrane protease
KW - transmembrane protease, serine 2 ( TMPRSS2 )
N1 - Accession Number: 34648068; Wang, Wei 1 Butler, Eboneé N. 2 Veguilla, Vic 2 Vassell, Russell 1 Terrig Thomas, J. 3 Moos, Malcolm 3 Ye, Zhiping 1 Hancock, Kathy 2 Weiss, Carol D. 1; Email Address: carol.weiss@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, United States 2: Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States 3: Cellular and Gene Therapy, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, United States; Source Info: Nov2008, Vol. 153 Issue 2, p111; Subject Term: VIRUSES; Subject Term: NEUTRALIZATION (Chemistry); Subject Term: INFLUENZA A virus; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: β-galactosidase ( β-gal ); Author-Supplied Keyword: A/Aichi/2/1968 ( Aichi ); Author-Supplied Keyword: A/Indonesia/5/2005 ( Ind ); Author-Supplied Keyword: A/New Caledonia/20/1999 ( NCD ); Author-Supplied Keyword: A/Puerto Rico/8/1934 ( PR ); Author-Supplied Keyword: A/Shangdong/9/1993 ( SD ); Author-Supplied Keyword: A/Solomon Islands/3/2006 ( SI ); Author-Supplied Keyword: A/South Carolina/1/1918 ( SC ); Author-Supplied Keyword: A/Thailand/1(KAN-1)/2004 ( TL ); Author-Supplied Keyword: A/Thailand/3(SP-83)/2004 ( TL-(SP-83) ); Author-Supplied Keyword: A/Turkey/1/2005 ( Trk ); Author-Supplied Keyword: A/Vietnam/1203/2004 ( VN ); Author-Supplied Keyword: A/Wisconsin/67/2005 ( Wis ); Author-Supplied Keyword: A/Wyoming/3/2003 ( Wyo ); Author-Supplied Keyword: any amino acid ( X ); Author-Supplied Keyword: any basic amino acid ( B ); Author-Supplied Keyword: centers for disease control and prevention ( CDC ); Author-Supplied Keyword: Food and Drug Administration ( FDA ); Author-Supplied Keyword: Hemagglutinin; Author-Supplied Keyword: hemagglutinin ( HA ); Author-Supplied Keyword: Hemagglutinin inhibition; Author-Supplied Keyword: hemagglutinin inhibition ( HAI ); Author-Supplied Keyword: human airway trypsin-like protease ( HAT ); Author-Supplied Keyword: human immunodeficiency virus ( HIV ); Author-Supplied Keyword: Influenza; Author-Supplied Keyword: luciferase ( Luc ); Author-Supplied Keyword: microneutralization ( MN ); Author-Supplied Keyword: murine leukemia virus ( MLV ); Author-Supplied Keyword: national institutes of health ( NIH ); Author-Supplied Keyword: neuraminidase ( NA ); Author-Supplied Keyword: Neutralization; Author-Supplied Keyword: Protease; Author-Supplied Keyword: Pseudotype; Author-Supplied Keyword: serine 2 ( TMPRSS2 ); Author-Supplied Keyword: subtilisin-like proprotein convertase ( SPC ); Author-Supplied Keyword: transmembrane protease; Author-Supplied Keyword: transmembrane protease, serine 2 ( TMPRSS2 ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jviromet.2008.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34648068&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105565823
T1 - Characteristics of grandmothers who have grandchildren with fetal alcohol syndrome or incomplete fetal alcohol syndrome.
AU - Kvigne VL
AU - Leonardson GR
AU - Borzelleca J
AU - Welty TK
Y1 - 2008/11//
N1 - Accession Number: 105565823. Language: English. Entry Date: 20090130. Revision Date: 20150820. Publication Type: Journal Article; research; tables/charts. Journal Subset: Continental Europe; Core Nursing; Europe; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Pediatric Care; Public Health. Grant Information: Supported through a memorandum of agreement between the IHS and the Centers for Disease Control and Prevention. NLM UID: 9715672.
KW - Fetal Alcohol Syndrome
KW - Grandparents
KW - Native Americans
KW - Case Control Studies
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Fetal Alcohol Syndrome -- Diagnosis
KW - Funding Source
KW - Health Services, Indigenous
KW - Mantel-Haenszel Test
KW - Medical Records
KW - Midwestern United States
KW - Odds Ratio
KW - Random Sample
KW - Record Review
KW - Human
SP - 760
EP - 765
JO - Maternal & Child Health Journal
JF - Maternal & Child Health Journal
JA - MATERN CHILD HEALTH J
VL - 12
IS - 6
CY - ,
PB - Springer Science & Business Media B.V.
AB - Introduction: Characteristics of Northern Plains American Indian maternal grandmothers who had grandchildren with fetal alcohol syndrome (FAS) or incomplete FAS are described to more effectively prevent fetal FAS and alcohol use during pregnancy. Methods: Study 1 had 27 maternal grandmothers who had grandchildren with FAS and Study 2 had 18 grandmothers with grandchildren who had incomplete FAS (cases) which were compared with 119 maternal grandmothers who had grandchildren without FAS (controls). The grandchildren were born between 1981 and 1993 on the Northern Plains. Medical records were manually reviewed for each case and control grandmother. Data were analyzed using Mantel-Haenszel chi square. Results: Study 1 case grandmothers were more likely to experience medical problems (70.4%) including trauma (48.1%) and injuries (51.9%) than the controls. Most of the Study 1 and 2 case grandmothers (92.6% and 77.8%, respectively) had alcohol use documented in their medical records compared to less than half of the control grandmothers. Seven (15.6%) of the case grandmothers had more than one grandchild in either Study 1 or Study 2. Conclusion: Maternal grandmothers who had grandchildren with FAS had significantly higher rates of alcohol use and alcohol-related medical problems than control grandmothers. Antenatal care providers should screen pregnant women for alcohol use at their first visit. The provider needs to ask the women who are using alcohol about their mothers' use of alcohol to provide appropriate care and counseling for the women and prevent FAS.
SN - 1092-7875
AD - Aberdeen Area Indian Health Service, Aberdeen, SD; kvi6@aol.com
U2 - PMID: 18196450.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Singh, Prachi F.
AU - Parra, Marcela
AU - Cadieux, Nathalie
AU - Brennan, Michael J.
T1 - A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2008/11//
VL - 154
IS - 11
M3 - Article
SP - 3469
EP - 3479
SN - 13500872
AB - The article offers information on the study conducted to determine the host reponse of three Mycobacterium tuberculosis PE_PGRS protiens. PE_PGRS 16, PE_PGRS_26 and PE_PGRS 33, the three Mycobacterium tuberculosis protein, were expressed in Mycobacterium smegmatis and used to determine the host response to members of its protein family. Strains of Mycobacterium smegmatis of PE_PGRS 33 and PE_PGRS 26 revealed cell death and increased release of lactate dehydrogenase in macrophage cultures. It is revealed that the life of mycobacterial pathogen is affected by the variable expression of different PE_PGRS proteins.
KW - Cell death
KW - Death (Biology)
KW - Mycobacterium tuberculosis
KW - Mycobacterial diseases
KW - Bacterial diseases -- Genetic aspects
KW - Tuberculosis -- Genetic aspects
KW - Mycobacterium
KW - Dehydrogenases
KW - Tuberculin
N1 - Accession Number: 35999737; Singh, Prachi F. 1; Parra, Marcela 1; Cadieux, Nathalie 1; Brennan, Michael J. 1; Email Address: mbrennan@aeras.org; Affiliations: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20910, USA; Issue Info: Nov2008, Vol. 154 Issue 11, p3469; Thesaurus Term: Cell death; Thesaurus Term: Death (Biology); Subject Term: Mycobacterium tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Bacterial diseases -- Genetic aspects; Subject Term: Tuberculosis -- Genetic aspects; Subject Term: Mycobacterium; Subject Term: Dehydrogenases; Subject Term: Tuberculin; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Illustrations: 4 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1099/mic.0.2008/019968-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kotewicz, Michael L.
AU - Mammel, Mark K.
AU - LeClerc, J. Eugene
AU - Cebula, Thomas A.
T1 - Optical mapping and 454 sequencing of Escherichia co/i 0157 : H7 isolates linked to the US 2006 spinach-associated outbreak.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2008/11//
VL - 154
IS - 11
M3 - Article
SP - 3518
EP - 3528
SN - 13500872
AB - The article presents a study regarding the 2006 escherichia coli O157: H7 outbreak caused by spinach in the U.S. It examines the chromosomal markers such as deletions, insertions, substitutions and single nucleotide polymorphism, of the outbreak strain. The researchers use optical maps for food-borne and bovine-derived isolates in the U.S. It states that the shiga toxic gene in the spinach is related to prophage in other strains. The researchers learn that there are different prophage variations in isolates gotten from two optical maps thus, changes appear in the source strain during its spread.
KW - Escherichia coli
KW - Epidemics
KW - Gene mapping
KW - Spinach
KW - Chromosome inversions
KW - Differentiable mappings
KW - Chromosome polymorphism
KW - Verocytotoxins
KW - United States
N1 - Accession Number: 35999741; Kotewicz, Michael L. 1; Mammel, Mark K. 1; LeClerc, J. Eugene 1; Cebula, Thomas A. 1; Email Address: thomas.cebula@FDA.HHS.gov; Affiliations: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Nov2008, Vol. 154 Issue 11, p3518; Thesaurus Term: Escherichia coli; Thesaurus Term: Epidemics; Subject Term: Gene mapping; Subject Term: Spinach; Subject Term: Chromosome inversions; Subject Term: Differentiable mappings; Subject Term: Chromosome polymorphism; Subject Term: Verocytotoxins; Subject: United States; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1099/mic.0.2008/019026-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35999741&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Murashov, Vladimir
AU - Howard, John
T1 - The US must help set international standards for nanotechnology.
JO - Nature Nanotechnology
JF - Nature Nanotechnology
Y1 - 2008/11//
VL - 3
IS - 11
M3 - Editorial
SP - 635
EP - 636
SN - 17483387
AB - The authors emphasize the importance of the involvement of U.S. government agencies and the private sector in international efforts to establish standards for nanotechnology. According to the authors, international standards are critical to support global trade and provide a foundation for risk management programmes aimed at human health and environmental protection. They say that such standards are used to support the regulatory work of global intergovernmental organizations.
KW - GOVERNMENT agencies -- United States
KW - PRIVATE sector
KW - INTERNATIONAL cooperation
KW - NANOTECHNOLOGY
KW - UNITED States -- Foreign relations
KW - UNITED States
N1 - Accession Number: 35119081; Murashov, Vladimir 1; Email Address: vladimir.murashov@cdc.hhs.gov Howard, John 1; Affiliation: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Washington, DC 20201, USA; Source Info: Nov2008, Vol. 3 Issue 11, p635; Subject Term: GOVERNMENT agencies -- United States; Subject Term: PRIVATE sector; Subject Term: INTERNATIONAL cooperation; Subject Term: NANOTECHNOLOGY; Subject Term: UNITED States -- Foreign relations; Subject Term: UNITED States; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Editorial
L3 - 10.1038/nnano.2008.323
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhong-Hua Liu
AU - Shin, Rick
AU - Ikemoto, Satoshi
T1 - Dual Role of Medial A10 Dopamine Neurons in Affective Encoding.
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
Y1 - 2008/11//
VL - 33
IS - 12
M3 - Article
SP - 3010
EP - 3020
SN - 0893133X
AB - Increasing evidence suggests that the activation of medial A10 neurons mediates positive affective encoding. However, little is known about the functions of the inhibition of midbrain dopamine neurons. Here we show evidence suggesting that the inhibition of medial A10 neurons mediates a negative affective state, leading to negative affective encoding, whereas blunting the activation of medial A10 neurons disrupts positive affective encoding involving food reward. We used a microinjection procedure, in which the D2 dopamine receptor agonist quinpirole was administered into the cell body region of the dopamine neurons, a procedure that reduces dopamine cell firing. Microinjections of quinpirole into the posteromedial ventral tegmental area, but not its more lateral counterparts, led to conditioned place aversion. Quinpirole administration to this site also decreased food intake and basal dopamine concentration in the ventromedial striatum, a major projection area of medial A10 neurons. In addition, moderate quinpirole doses that did not lead to conditioned place aversion or disrupt food intake abolished food-conditioned place preference, suggesting that blunting dopamine impulse activity in response to food reward disrupts positive affective encoding in associated external stimuli. Our data support the hypothesis that activation of medial A10 dopamine neurons mediates a positive affective state, leading to positive affective encoding, while their inhibition mediates a negative affective state, leading to negative affective encoding. Together with previous findings, we propose that medial A10 neurons are an important component of the mechanism via which animals learn to avoid negative incentive stimuli.Neuropsychopharmacology (2008) 33, 3010–3020; doi:10.1038/npp.2008.4; published online 6 February 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Neuropsychopharmacology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOPAMINERGIC neurons
KW - NEUROPSYCHOPHARMACOLOGY
KW - AVERSION
KW - MICROINJECTIONS
KW - MESENCEPHALON
KW - avoidance
KW - conditioned place preference
KW - incentive motivation
KW - nucleus accumbens
KW - substantia nigra
KW - ventral tegmental area
N1 - Accession Number: 34741526; Zhong-Hua Liu 1 Shin, Rick 1 Ikemoto, Satoshi 1; Email Address: sikemoto@mail.nih.gov; Affiliation: 1: Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD, USA; Source Info: Nov2008, Vol. 33 Issue 12, p3010; Subject Term: DOPAMINERGIC neurons; Subject Term: NEUROPSYCHOPHARMACOLOGY; Subject Term: AVERSION; Subject Term: MICROINJECTIONS; Subject Term: MESENCEPHALON; Author-Supplied Keyword: avoidance; Author-Supplied Keyword: conditioned place preference; Author-Supplied Keyword: incentive motivation; Author-Supplied Keyword: nucleus accumbens; Author-Supplied Keyword: substantia nigra; Author-Supplied Keyword: ventral tegmental area; Number of Pages: 11p; Illustrations: 1 Diagram, 5 Graphs; Document Type: Article
L3 - 10.1038/npp.2008.4
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, Chung-Tung Jordan
T1 - How Do Consumers Interpret Health Messages on Food Labels?
JO - Nutrition Today
JF - Nutrition Today
Y1 - 2008/11//Nov/Dec2008
VL - 43
IS - 6
M3 - Article
SP - 267
EP - 272
SN - 0029666X
AB - The article examines a study conducted by the U.S. Food and Drug Administration (FDA) through the Internet to understand the causal relationships between health claims and other health messages, and consumer responses. It discusses the methodology used in the study. It examines the results gathered from the study's respondents. It notes that the study reveals that consumers have dissimilar levels of familiarity with different nutrients and diet-disease relationships.
KW - FOOD -- Quality
KW - FOOD labeling
KW - CONSUMER research
KW - NUTRITION
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 35845714; Lin, Chung-Tung Jordan 1; Email Address: Chung-tung.lin@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-020, College Park, MD 20740; Source Info: Nov/Dec2008, Vol. 43 Issue 6, p267; Subject Term: FOOD -- Quality; Subject Term: FOOD labeling; Subject Term: CONSUMER research; Subject Term: NUTRITION; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105607459
T1 - How do consumers interpret health messages on food labels?
AU - Lin CJ
Y1 - 2008/11//Nov/Dec2008
N1 - Accession Number: 105607459. Language: English. Entry Date: 20090220. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Nutrition. Grant Information: US Food and Drug Administration. NLM UID: 0055201.
KW - Consumer Attitudes
KW - Consumer Health Information -- Evaluation
KW - Decision Making
KW - Food Labeling
KW - Shopping
KW - Adolescence
KW - Adult
KW - Calcium, Dietary
KW - Chronic Disease -- Risk Factors
KW - Descriptive Statistics
KW - Female
KW - Fruit Juices
KW - Funding Source
KW - Health Beliefs -- Evaluation
KW - Health Knowledge -- Evaluation
KW - Heart Diseases
KW - Hypertension
KW - Internet
KW - Male
KW - Middle Age
KW - Nutrition
KW - Orange
KW - Osteoporosis
KW - Potassium
KW - Prospective Studies
KW - Regression
KW - Survey Research
KW - United States
KW - United States Food and Drug Administration
KW - Yogurt
KW - Human
SP - 267
EP - 272
JO - Nutrition Today
JF - Nutrition Today
JA - NUTR TODAY
VL - 43
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - How do consumers interpret labeling statements claiming the nutritional or health benefits of a food product? What impacts do these statements have on how consumers make shopping decisions? These are important questions for regulators, the industry, and nutrition educators and professionals in communicating with consumers about food labels and dietary choices. To help provide consumers more and better information about foods, the US Food and Drug Administration conducted an Internet study from January to March 2006 to understand the causal relationships between health claims and other health messages and consumer responses. The study suggests that consumers have different levels of familiarity with different nutrients and diet-disease relationships. Both consumer familiarity with a nutrient or diet-disease relationship and the type of health message can affect consumer interpretation of health messages and their perceptions of products. More detailed health messages seem to have stronger impacts on consumers when the nutrients or diet-disease links are less familiar or unknown.
SN - 0029-666X
AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Pkwy, HFS-020, College Park, MD 20740; Chung-tung.lin@fda.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105585546
T1 - Adiposity measures and oxidative stress among police officers.
AU - Charles LE
AU - Burchfiel CM
AU - Violanti JM
AU - Fekedulegn D
AU - Slaven JE
AU - Browne RW
AU - Hartley TA
AU - Andrew ME
Y1 - 2008/11//
N1 - Accession Number: 105585546. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. NLM UID: 101264860.
KW - Adipose Tissue Distribution -- Physiology
KW - Oxidative Stress -- Physiology
KW - Police
KW - Adult
KW - Ascorbic Acid -- Blood
KW - Benzopyrans -- Blood
KW - Biological Markers -- Blood
KW - Body Mass Index
KW - Cross Sectional Studies
KW - Female
KW - Glutathione -- Blood
KW - Male
KW - Middle Age
KW - Oxidoreductases -- Blood
KW - Human
SP - 2489
EP - 2497
JO - Obesity (19307381)
JF - Obesity (19307381)
JA - OBESITY (19307381)
VL - 16
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 1930-7381
AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA. lcharles@cdc.gov
U2 - PMID: 18719659.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105591747
T1 - The clinical significance of statistical significance.
AU - Kane RC
Y1 - 2008/11//
N1 - Accession Number: 105591747. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Data Analysis
KW - Statistics
KW - Education, Continuing (Credit)
SP - 1129
EP - 1133
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 13
IS - 11
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - Modern clinical trials provide the evidence for most therapeutic advances, and that evidence, expressed in a statistical format, is used to draw inferences about a population from the study's results. Clinician judgment translates these inferences for best individual patient care, but many clinicians struggle with the statistical interpretation of trial results. This review provides a clinical and non-Bayesian perspective on some key elements in the statistical design, analysis, and interpretation of randomized, comparative, phase III clinical trials intended to demonstrate a better outcome (superiority) than with a control treatment.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. Robert.kane@fda.hhs.gov
U2 - PMID: 18984874.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhang, Yujia
AU - Martin, Stacey W.
AU - Rose Jr, Charles E.
AU - Biagini, Raymond E.
AU - Franzke, Laura H.
AU - Smith, Jerry P.
AU - Sammons, Deborah L.
AU - Robertson, Shirley A.
AU - McNeil, Michael M.
T1 - Evaluation of body mass index, pre-vaccination serum progesterone levels and anti-anthrax protective antigen immunoglobulin G on injection site adverse events following anthrax vaccination in women.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/11//
VL - 17
IS - 11
M3 - Article
SP - 1060
EP - 1067
SN - 10538569
AB - Background In 2002, CDC initiated the Anthrax Vaccination Program (AVP) to provide voluntary pre-exposure anthrax vaccination for individuals at high risk for exposure to Bacillus anthracis spores. The AVP offered an opportunity to investigate hypothesized reasons for a reported gender difference in injection site adverse events (AEs) following anthrax vaccine adsorbed (AVA). Objectives To evaluate in women the impact of body mass index (BMI), pre-vaccination serum progesterone levels, and pre-vaccination anti-anthrax protective antigen immunoglobulin G concentrations (anti-PA IgG) on the occurrence of AEs following subcutaneous AVA vaccination. Methods Participants' BMI was determined at enrollment. Also, pre-vaccination blood samples were assayed for serum progesterone and anti-PA IgG. Post-vaccination solicited AEs were recorded by participants using a 4-day diary card. Results Obese group had an elevated risk for arm soreness. Decreased pre-vaccination serum progesterone level was associated with arm swelling. Increased pre-vaccination anti-PA IgG was associated with itching on the arm; and within the obese group, was associated with arm swelling, lump or knot, redness, soreness, and warmth. Conclusions In AVA vaccinated women, obesity was associated with arm soreness and decreased pre-vaccination serum progesterone levels were associated with increased rate of arm swelling. Increased pre-vaccination anti-PA IgG may be associated with an increased frequency of itching on the arm, and in obese women, may increase the occurrence of arm swelling, lump or knot, redness, and warmth. Administering AVA according to a woman's menstrual phase may reduce the occurrence of certain injection site reactions. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707291; Zhang, Yujia 1; Martin, Stacey W. 2; Rose Jr, Charles E. 2; Biagini, Raymond E. 3; Franzke, Laura H. 4; Smith, Jerry P. 3; Sammons, Deborah L. 3; Robertson, Shirley A. 3; McNeil, Michael M. 2; Affiliations: 1: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: Division of Alliance Management, National Center for Public Health Informatics, Centers for Disease Control and Prevention, Atlanta, GA, USA; Issue Info: Nov2008, Vol. 17 Issue 11, p1060; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1657
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Colman, Eric
AU - Szarfman, Ana
AU - Wyeth, Jo
AU - Mosholder, Andrew
AU - Jillapalli, Devanand
AU - Levine, Jonathan
AU - Avigan, Mark
T1 - An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/11//
VL - 17
IS - 11
M3 - Article
SP - 1068
EP - 1076
SN - 10538569
AB - Background We detected disproportionate reporting of amyotrophic lateral sclerosis (ALS) with HMG-CoA-reductase inhibitors (statins) in the Food and Drug Administration's (FDA) spontaneous adverse event (AE) reporting system (AERS). Purpose To describe the original ALS signal and to provide additional context for interpreting the signal by conducting retrospective analyses of data from long-term, placebo-controlled clinical trials of statins. Methods The ALS signal was detected using the multi-item gamma Poisson shrinker (MGPS) algorithm. All AERS cases of ALS reported in association with use of a statin were individually reviewed by two FDA neurologists. Manufacturers of lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, cerivastatin, and rosuvastatin were requested to provide the number of cases of ALS diagnosed during all of their placebo-controlled statin trials that were at least 6 months in duration. Results There were 91 US and foreign reports of ALS with statins in AERS. The data mining signal scores for ALS and statins ranged from 8.5 to 1.6. Data were obtained from 41 statin clinical trials ranging in duration from 6 months to 5 years and representing approximately 200 000 patient-years of exposure to statin and approximately 200 000 patient-years of exposure to placebo. Nine cases of ALS were reported in statin-treated patients and 10 cases in placebo-treated patients. Conclusions Although we observed a data mining signal for ALS with statins in FDA's AERS, retrospective analyses of 41 statin clinical trials did not reveal an increased incidence of ALS in subjects treated with a statin compared with placebo. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707297; Colman, Eric 1; Szarfman, Ana 2,3; Wyeth, Jo 4; Mosholder, Andrew 4; Jillapalli, Devanand 5; Levine, Jonathan 6; Avigan, Mark 4; Affiliations: 1: Division of Metabolism and Endocrinology Products, United States Food and Drug Administration, Silver Spring, MD, USA; 2: Division of Cardiovascular and Renal Products, United States Food and Drug Administration, Silver Spring, MD, USA; 3: Division of Biometrics VI, Office of Biostatistics, Office of Translational Sciences, United States Food and Drug Administration, Silver Spring, MD, USA; 4: Office of Surveillance and Epidemiology, United States Food and Drug Administration, Silver Spring, MD, USA; 5: Division of Neurology Products, United States Food and Drug Administration, Silver Spring, MD, USA; 6: Office of Critical Path Programs, Center for Drug Evaluation and Research and Office of the Commissioner, United States Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Nov2008, Vol. 17 Issue 11, p1068; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1643
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Najar, Barbara Elisse
AU - Hubbard, Heddy
T1 - The Value of Nurse Leaders on Federal Advisory Panels: Experience With the Agency for Healthcare Research and Quality.
JO - Policy, Politics & Nursing Practice
JF - Policy, Politics & Nursing Practice
Y1 - 2008/11//
VL - 9
IS - 4
M3 - Article
SP - 299
EP - 304
SN - 15271544
AB - This article focuses on interviews with six nationally known nurse leaders who have been, or currently are, members of National Advisory Committee for the Healthcare Research and Quality (NAC). The nurse leaders are either deans and/or professors of schools of nursing. They discuss how their participation on the NAC serves the Federal Government and what they view as the benefits they now offer the nursing profession from being on the NAC such as an increased focus on evidence-based research. These nurse leaders also discuss what they bring to the table in terms of helping to influence public policy vis a vis health care quality, safety, and scientific evidence and their bearing on health care systems and services. They also talk about the myriad Federal opportunities that exist beyond this influential panel for nurse leaders to help continue shaping the future of health care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Policy, Politics & Nursing Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING -- Practice
KW - NURSES
KW - MEDICAL care -- Research
KW - NURSE practitioners
KW - NURSING schools
KW - Health care quality
KW - Patient safety
KW - Public health
N1 - Accession Number: 36312563; Najar, Barbara Elisse 1 Hubbard, Heddy 2; Email Address: hhubbard@auanet.org; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: American Urological Association, Linthicum, Maryland; Source Info: Nov2008, Vol. 9 Issue 4, p299; Subject Term: NURSING -- Practice; Subject Term: NURSES; Subject Term: MEDICAL care -- Research; Subject Term: NURSE practitioners; Subject Term: NURSING schools; Author-Supplied Keyword: Health care quality; Author-Supplied Keyword: Patient safety; Author-Supplied Keyword: Public health; NAICS/Industry Codes: 611519 Other Technical and Trade Schools; NAICS/Industry Codes: 611510 Technical and trade schools; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van Rijckevorsel, Gini G. C.
AU - Sonder, Gerard J. B.
AU - Bovee, Lian P. M. J.
AU - Thiesbrummel, Harold F. J.
AU - Geskus, Ronald B.
AU - Van Den Hoek, Anneke
T1 - Trends in Hepatitis A, B, and Shigellosis Compared With Gonorrhea and Syphilis in Men Who Have Sex With Men in Amsterdam, 1992-2006.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2008/11//
VL - 35
IS - 11
M3 - Article
SP - 930
EP - 934
SN - 01485717
AB - The article presents a study on the comparison of the trends in hepatitis A, acute hepatitis B and shigellosis and the trends of gonorrhea and infectious syphilis in men who have sex with men (MSM) in Amsterdam, Netherlands. It mentions that the reported case of hepatitis A, acute hepatitis B, and shigellosis and the case of newly diagnosed patients with gonorrhea and syphilis in the Public Health STI outpatient department from January 1, 1992 to December 31, 2006 were used. The result reveals that the former variables do not follow the trends of conventional sexually transmitted infection in MSM which entails differences in transmission dynamics.
KW - TREND analysis
KW - COMPARATIVE studies
KW - HEPATITIS B virus
KW - RESEARCH
KW - HEPATITIS A virus
KW - GONORRHEA
KW - SHIGELLOSIS
KW - SYPHILIS
KW - MEN -- Sexual behavior
KW - AMSTERDAM (Netherlands)
KW - NETHERLANDS
N1 - Accession Number: 35564534; Van Rijckevorsel, Gini G. C. 1; Email Address: gvrijckevorsel@ggd.amsterdam.nl Sonder, Gerard J. B. 1 Bovee, Lian P. M. J. 1 Thiesbrummel, Harold F. J. 2 Geskus, Ronald B. 1,3 Van Den Hoek, Anneke 1,4; Affiliation: 1: Public Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, 1018 WT Amsterdam The Netherlands 2: Public Health Setvice Amsterdam, Sexual Transmitted Infections Clinic, Nieuwe Achtergracht 100, 1018 WT Amsterdam The Netherlands 3: Academic Medical Center, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands 4: Academic Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Source Info: Nov2008, Vol. 35 Issue 11, p930; Subject Term: TREND analysis; Subject Term: COMPARATIVE studies; Subject Term: HEPATITIS B virus; Subject Term: RESEARCH; Subject Term: HEPATITIS A virus; Subject Term: GONORRHEA; Subject Term: SHIGELLOSIS; Subject Term: SYPHILIS; Subject Term: MEN -- Sexual behavior; Subject Term: AMSTERDAM (Netherlands); Subject Term: NETHERLANDS; Number of Pages: 5p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1097/OLQ.0b013e3181812cdf
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105566120
T1 - Trends in hepatitis A, B, and shigellosis compared with gonorrhea and syphilis in men who have sex with men in Amsterdam, 1992-2006.
AU - Van Rijckevorsel GGC
AU - Sonder GJB
AU - Bovée LPM
AU - Thiesbrummel HFJ
AU - Geskus RB
AU - Van Den Hoek A
Y1 - 2008/11//
N1 - Accession Number: 105566120. Language: English. Entry Date: 20090123. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7705941.
KW - Anal Intercourse
KW - Dysentery, Bacillary
KW - Gonorrhea -- Trends
KW - Hepatitis A -- Trends
KW - Hepatitis B -- Trends
KW - Gay Persons -- Netherlands
KW - Syphilis -- Trends
KW - Male
KW - Netherlands
KW - Regression
KW - Risk Taking Behavior
KW - Sexually Transmitted Diseases -- Transmission
KW - Human
SP - 930
EP - 934
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 35
IS - 11
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Public Health Service Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, the Netherlands. gvrijckevorsel@ggd.amsterdam.nl
U2 - PMID: 18685550.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Berdahi, Terceira A.
AU - McQuillan, Julia
T1 - Occupational Racial Composition and Nonfatal Work Injuries.
JO - Social Problems
JF - Social Problems
Y1 - 2008/11//
VL - 55
IS - 4
M3 - Article
SP - 549
EP - 572
SN - 00377791
AB - Hierarchical generalized linear models of individuals within occupations show that there is an association between occupational racial composition and workplace injuries, but this association is only statistically significant for white men in the model controlling for relevant occupational- and individual-level characteristics. A 10% increase in the occupation percent black is associated with a 28% increase in injury risk. Contrary to expectations, white men have the highest adjusted odds of injury; white women and black men have significantly lower odds of injury than white men. Additionally, occupation-level environmental hazards and individual-level education, hours worked per week, jobs with insurance benefits, working in the South, and specific industries are associated with differential injury risk. These findings are consistent with labor market theories that suggest social closure, market position, and individual skills contribute to differential labor market outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of Social Problems is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WORK-related injuries
KW - DIVERSITY in the workplace
KW - LABOR supply
KW - WORK environment
KW - INDUSTRIAL safety
KW - HUMAN capital
KW - MINORITIES -- Employment
KW - ACCIDENTS
KW - LABOR market
KW - INDUSTRIAL hygiene
KW - RACE
N1 - Accession Number: 35266324; Berdahi, Terceira A. 1; Email Address: terceira.berdahl@ahrq.gov; McQuillan, Julia 2; Affiliations: 1 : Agency for Healthcare Research and Quality.; 2 : University of Nebraska-Lincoln.; Source Info: Nov2008, Vol. 55 Issue 4, p549; Historical Period: 1979 to 2000; Subject Term: WORK-related injuries; Subject Term: DIVERSITY in the workplace; Subject Term: LABOR supply; Subject Term: WORK environment; Subject Term: INDUSTRIAL safety; Subject Term: HUMAN capital; Subject Term: MINORITIES -- Employment; Subject Term: ACCIDENTS; Subject Term: LABOR market; Subject Term: INDUSTRIAL hygiene; Subject Term: RACE; Number of Pages: 24p; Document Type: Article
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DP - EBSCOhost
DB - ahl
ER -
TY - JOUR
AU - Bowyer, J.F.
AU - Latendresse, J.R.
AU - Delongchamp, R.R.
AU - Muskhelishvili, L.
AU - Warbritton, A.R.
AU - Thomas, M.
AU - Tareke, E.
AU - McDaniel, L.P.
AU - Doerge, D.R.
T1 - Corrigendum to “The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats” [Toxicol. Appl. Pharmacol. 230 (2008) 208–215]
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/11//
VL - 232
IS - 3
M3 - Correction notice
SP - 498
EP - 498
SN - 0041008X
N1 - Accession Number: 34869680; Bowyer, J.F. 1 Latendresse, J.R. 2 Delongchamp, R.R. 3 Muskhelishvili, L. 2 Warbritton, A.R. 2 Thomas, M. 1 Tareke, E. 4 McDaniel, L.P. 5 Doerge, D.R. 6; Email Address: daniel.doerge@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA 2: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Toxicologic Pathology Associates, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Department of Epidemiology, University of Arkansas for Medical Sciences, College of Public Health, 4301 W Markham Street, #820, Little Rock, AR 72205, USA 4: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Personalized Nutrition and Medicine, 3900 NCTR Road, Jefferson, AR 72079, USA 5: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA 6: U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Nov2008, Vol. 232 Issue 3, p498; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.taap.2008.02.028
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34869680&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2008-16478-004
AN - 2008-16478-004
AU - Sussner, Bradley D.
AU - Kline, Anna
AU - Smelson, David A.
AU - Losonczy, Miklos
AU - Salvatore, Scott J.
T1 - The role of psychosocial characteristics in premature discharge from residential services for homeless veterans.
JF - Psychological Services
JO - Psychological Services
JA - Psychol Serv
Y1 - 2008/11//
VL - 5
IS - 4
SP - 341
EP - 350
CY - US
PB - Educational Publishing Foundation
SN - 1541-1559
SN - 1939-148X
AD - Sussner, Bradley D., United States Department of Veterans Affairs, Department of Veterans Affairs New Jersey Health Care System, 151 Knollcroft Road (116A), Lyons, NJ, US, 07939
N1 - Accession Number: 2008-16478-004. Partial author list: First Author & Affiliation: Sussner, Bradley D.; United States Department of Veterans Affairs, Department of Veterans Affairs New Jersey Health Care System, Lyons, NJ, US. Release Date: 20081124. Correction Date: 20120109. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Homeless; Military Veterans; Psychosocial Factors; Residential Care Institutions. Minor Descriptor: Mental Health Services. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Alcohol Use Disorders Identification Test--Consumption Questions; Beck Depression Inventory–II DOI: 10.1037/t00742-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2008. Publication History: Accepted Date: Jul 30, 2008; Revised Date: Jul 1, 2008; First Submitted Date: Nov 14, 2007. Copyright Statement: Public Domain
AB - Residential programs can improve the lives of homeless individuals, but many participants leave prematurely. Certain characteristics evident upon admission may help to identify those at greatest risk of early discharge. The records of 197 unique admissions to a homeless veterans program were reviewed. Subjects completed a psychosocial assessment, a diagnostic interview, and depression and alcohol use severity screenings. Alcohol use severity, days of abstinence, and an antisocial behavior disorder were significant independent predictors of type of discharge. The overall model accounted for 14.5% of the variance in type of discharge. Targeted interventions may be needed to help veterans at risk of premature discharge to remain engaged in treatment and to assist them in the transition back to the community. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homeless
KW - veteran
KW - premature discharge
KW - residential services
KW - psychosocial characteristics
KW - substance abuse
KW - 2008
KW - Drug Abuse
KW - Homeless
KW - Military Veterans
KW - Psychosocial Factors
KW - Residential Care Institutions
KW - Mental Health Services
KW - 2008
DO - 10.1037/a0013791
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16478-004&site=ehost-live&scope=site
UR - bradley.sussner@va.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16493-004
AN - 2008-16493-004
AU - McMillen, Curtis
AU - Zayas, Luis E.
AU - Books, Samantha
AU - Lee, Madeline
T1 - Quality assurance and improvement practice in mental health agencies: Roles, activities, targets and contributions.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2008/11//
VL - 35
IS - 6
SP - 458
EP - 467
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - McMillen, Curtis, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Washington University Campus Box 1196, One Brookings Drive, St. Louis, MO, US, 63130
N1 - Accession Number: 2008-16493-004. PMID: 18688707 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: McMillen, Curtis; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, St. Louis, MO, US. Release Date: 20090413. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Health Services; Quality Control; Quality of Care; Health Care Administration. Minor Descriptor: Professional Licensing; Professional Personnel; Roles. Classification: Health & Mental Health Services (3370); Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2008.
AB - Accompanying the rise in the number of mental health agency personnel tasked with quality assurance and improvement (QA/I) responsibilities is an increased need to understand the nature of the work these professionals undertake. Four aspects of the work of quality assurance and improvement (QA/I) professionals in mental health were explored in this qualitative study: their perceived roles, their major activities, their QA/I targets, and their contributions. In-person interviews were conducted with QA/I professionals at 16 mental health agencies. Respondents perceived their roles at varying levels of complexity, focused on different targets, and used different methods to conduct their work. Few targets of QA/I work served as indicators of high quality care. Most QA/I professionals provided concrete descriptions of how they had improved agency services, while others could describe none. Accreditation framed much of agency QA/I work, perhaps to its detriment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - quality assurance
KW - improvement practice
KW - mental health agencies
KW - roles
KW - contributions
KW - accreditation
KW - 2008
KW - Mental Health Services
KW - Quality Control
KW - Quality of Care
KW - Health Care Administration
KW - Professional Licensing
KW - Professional Personnel
KW - Roles
KW - 2008
U1 - Sponsor: National Institute of Mental Health, US. Grant: P30 MH 068579. Recipients: No recipient indicated
DO - 10.1007/s10488-008-0189-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16493-004&site=ehost-live&scope=site
UR - cmcmille@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14862-009
AN - 2008-14862-009
AU - González-Cortés, Carolina
AU - Salinas-Lara, Citlaltepetl
AU - Gómez-López, Marcos Artemio
AU - Tena-Suck, Martha Lilia
AU - Pérez-De La Cruz, Verónica
AU - Rembao-Bojórquez, Daniel
AU - Pedraza-Chaverrí, José
AU - Gómez-Ruiz, Celedonio
AU - Galván-Arzate, Sonia
AU - Ali, Syed F.
AU - Santamaría, Abel
T1 - Iron porphyrinate Fe(TPPS) reduces brain cell damage in rats intrastriatally lesioned by quinolinate.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2008/11//Nov-Dec, 2008
VL - 30
IS - 6
SP - 510
EP - 519
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Santamaría, Abel, Laboratorio de Aminoacidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Insurgentes Sur 3877, Mexico, Mexico, D.F. 14269
N1 - Accession Number: 2008-14862-009. PMID: 18579343 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: González-Cortés, Carolina; Laboratorio de Aminoacidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, S.S.A., Mexico, Mexico. Release Date: 20081027. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Santamaría, Abel. Major Descriptor: Brain Damage; Immunoreactivity; Inflammation; Brain Lesions (Experimental). Minor Descriptor: Animal Models; Neurotoxicity; Nitric Oxide; Nitrogen; Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov-Dec, 2008.
AB - It has been recently demonstrated that the reactive nitrogen species (RNS) peroxynitrite (ONOO-) is involved in the neurotoxic pattern produced by quinolinic acid in the rat brain [V. Pérez-De La Cruz, C. González- Cortés, S. Galván-Arzate, O.N. Medína-Campos, F. Pérez-Severiano, S. F. Ali, J. Pedraza-Chaverrí, A. Santamaría, Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III), Neuroscience 135 (2005) 463-474.]. The aim of this work was to investigate whether ONOO- can also be responsible for morphological alterations and inflammatory events in the same paradigm. For this purpose, we evaluated the effect of a pre-treatment with the iron porphyrinate Fe(TPPS), a well-known ONOO- decomposition catalyst (10 mg/kg, i.p., 120 min before lesion), on the quinolinate-induced striatal cell damage and immunoreactivities to glial-fibrilar acidic protein (GFAP), interleukin 6 (IL-6) and inducible nitric oxide synthase (iNOS), one and seven days after the intrastriatal infusion of quinolinate (240 nmol/μl) to rats. The striatal tissue from animals lesioned by quinolinate showed a significant degree of damage and enhanced immunoreactivities to GFAP, IL-6 and iNOS, both at 1 and 7 days post-lesion. Pre-treatment of rats with Fe(TPPS) significantly attenuated or prevented all these markers at both post-lesion times tested, except for GFAP immunoreactivity at 7 days post-lesion and iNOS immunoreactivity at 1 day post-lesion. Altogether, our results suggest that ONOO- is actively participating in triggering inflammatory events and morphological alterations in the toxic model produced by quinolinate, since the use of agents affecting its formation, such as Fe(TPPS), are effective experimental tools to reduce the brain lesions associated to excitotoxic and oxidative damage. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Fe(TPPS) iron porphyrinate
KW - rats
KW - brain cell damage
KW - brain lesions
KW - quinolinate
KW - peryoxinitrite
KW - excitotoxicity
KW - oxidative stress
KW - nitrergic stress
KW - inflammatory events
KW - 2008
KW - Brain Damage
KW - Immunoreactivity
KW - Inflammation
KW - Brain Lesions (Experimental)
KW - Animal Models
KW - Neurotoxicity
KW - Nitric Oxide
KW - Nitrogen
KW - Rats
KW - 2008
U1 - Sponsor: Consejo Nacional de Ciencia y Tecnología, Mexico. Grant: 48370-Q. Recipients: Santamaría, Abel
U1 - Sponsor: DGAPA PAPIIT. Grant: IN 207007. Recipients: Pedraza-Chaverrí, José
DO - 10.1016/j.ntt.2008.05.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14862-009&site=ehost-live&scope=site
UR - absada@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15600-005
AN - 2008-15600-005
AU - Berdahl, Terceira A.
AU - McQuillan, Julia
T1 - Occupational racial composition and nonfatal work injuries.
JF - Social Problems
JO - Social Problems
JA - Soc Probl
Y1 - 2008/11//
VL - 55
IS - 4
SP - 549
EP - 572
CY - US
PB - University of California Press
SN - 0037-7791
SN - 1533-8533
AD - Berdahl, Terceira A., Center for Financing, Access, and Cost Trends, Agency for Health Care Research and Quality, 540 Gaither Road, Suite 5000, Rockville, MD, US, 20850
N1 - Accession Number: 2008-15600-005. Partial author list: First Author & Affiliation: Berdahl, Terceira A.; Agency for Health Care Research and Quality, Rockville, MD, US. Other Publishers: Oxford University Press. Release Date: 20091116. Correction Date: 20150629. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Occupations; Racial and Ethnic Differences; Work Related Illnesses; Working Conditions. Minor Descriptor: Social Equality. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 24. Issue Publication Date: Nov, 2008. Copyright Statement: All rights reserved. Society for the Study of Social Problems, Inc. 2008.
AB - Is there an association between occupational racial composition and nonfatal workplace injuries? Guided by several labor market theories (queuing, social closure, devaluation, poor market position, and human capital), we use occupational data from the U.S. Census and Dictionary of Occupational Titles combined with individual data from the National Longitudinal Survey of Youth to answer this question. Hierarchical generalized linear models of individuals within occupations show that there is an association between occupational racial composition and workplace injuries, but this association is only statistically significant for white men in the model controlling for relevant occupational and individual level characteristics. A 10 percent increase in the occupation percent black is associated with a 28 percent increase in injury risk. Contrary to expectations, white men have the highest adjusted odds of injury; white women and black men have significantly lower odds of injury than white men. Additionally, occupation-level environmental hazards and individual-level education, hours worked per week, jobs with insurance benefits, working in the South, and specific industries are associated with differential injury risk. These findings are consistent with labor market theories that suggest social closure, market position, and individual skills contribute to differential labor market outcomes. We demonstrate that sociological theories of labor market inequality are useful for understanding workplace injury risk, and that workplace injuries should be studied as an outcome of social inequality. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nonfatal work injuries
KW - occupational racial composition
KW - occupations
KW - workplace injury risk
KW - social inequality
KW - 2008
KW - Injuries
KW - Occupations
KW - Racial and Ethnic Differences
KW - Work Related Illnesses
KW - Working Conditions
KW - Social Equality
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality, US. Recipients: No recipient indicated
DO - 10.1525/sp.2008.55.4.549
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15600-005&site=ehost-live&scope=site
UR - terceira.berdahl@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-14489-011
AN - 2008-14489-011
AU - Kvigne, Valborg L.
AU - Leonardson, Gary R.
AU - Borzelleca, Joseph
AU - Welty, Thomas K.
T1 - Characteristics of grandmothers who have grandchildren with fetal alcohol syndrome or incomplete fetal alcohol syndrome.
JF - Maternal and Child Health Journal
JO - Maternal and Child Health Journal
JA - Matern Child Health J
Y1 - 2008/11//
VL - 12
IS - 6
SP - 760
EP - 765
CY - Germany
PB - Springer
SN - 1092-7875
SN - 1573-6628
AD - Kvigne, Valborg L., 2013 W 15th St #1, Sioux Falls, SD, US, 57104
N1 - Accession Number: 2008-14489-011. PMID: 18196450 Partial author list: First Author & Affiliation: Kvigne, Valborg L.; Aberdeen Area Indian Health Service, Aberdeen, SD, US. Release Date: 20090316. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Fetal Alcohol Syndrome; Grandchildren; Grandparents. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2008.
AB - Introduction: Characteristics of Northern Plains American Indian maternal grandmothers who had grandchildren with fetal alcohol syndrome (FAS) or incomplete FAS are described to more effectively prevent fetal FAS and alcohol use during pregnancy. Methods: Study 1 had 27 maternal grandmothers who had grandchildren with FAS and Study 2 had 18 grandmothers with grandchildren who had incomplete FAS (cases) which were compared with 119 maternal grandmothers who had grandchildren without FAS (controls). The grandchildren were born between 1981 and 1993 on the Northern Plains. Medical records were manually reviewed for each case and control grandmother. Data were analyzed using Mantel-Haenszel chi square. Results: Study 1 case grandmothers were more likely to experience medical problems (70.4%) including trauma (48.1%) and injuries (51.9%) than the controls. Most of the Study 1 and 2 case grandmothers (92.6% and 77.8%, respectively) had alcohol use documented in their medical records compared to less than half of the control grandmothers. Seven (15.6%) of the case grandmothers had more than one grandchild in either Study 1 or Study 2. Conclusion: Maternal grandmothers who had grandchildren with FAS had significantly higher rates of alcohol use and alcohol-related medical problems than control grandmothers. Antenatal care providers should screen pregnant women for alcohol use at their first visit. The provider needs to ask the women who are using alcohol about their mothers' use of alcohol to provide appropriate care and counseling for the women and prevent FAS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fetal alcohol syndrome
KW - grandmothers
KW - grandchildren
KW - American Indians
KW - 2008
KW - American Indians
KW - Fetal Alcohol Syndrome
KW - Grandchildren
KW - Grandparents
KW - 2008
U1 - Sponsor: IHS/Centers for Disease Control and Prevention. Recipients: No recipient indicated
DO - 10.1007/s10995-007-0308-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-14489-011&site=ehost-live&scope=site
UR - twelty@earthlink.net
UR - jborzelleca@mcvh-vcu.edu
UR - mpr@zipmt.com
UR - kvig6@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17313-002
AN - 2008-17313-002
AU - Korthuis, P. Todd
AU - Zephyrin, Laurie C.
AU - Fleishman, John A.
AU - Saha, Somnath
AU - Josephs, Joshua S.
AU - McGrath, Moriah M.
AU - Hellinger, James
AU - Gebo, Kelly A.
T1 - Health-related quality of life in HIV-infected patients: The role of substance use.
JF - AIDS Patient Care and STDs
JO - AIDS Patient Care and STDs
JA - AIDS Patient Care STDS
Y1 - 2008/11//
VL - 22
IS - 11
SP - 859
EP - 867
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1087-2914
SN - 1557-7449
AD - Korthuis, P. Todd, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code L-475, Portland, OR, US, 97239-3098
N1 - Accession Number: 2008-17313-002. PMID: 19025480 Partial author list: First Author & Affiliation: Korthuis, P. Todd; Department of Medicine, Oregon Health & Science University, Portland, OR, US. Institutional Authors: HIV Research Network. Release Date: 20091207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Saha, Somnath. Major Descriptor: Chronicity (Disorders); Drug Abuse; Health; HIV; Quality of Life. Classification: Immunological Disorders (3291). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: SF-36 Health Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2008. Copyright Statement: Mary Ann Liebert, Inc.
AB - HIV infection and substance use disorders are chronic diseases with complex contributions to health-related quality of life (HRQOL). We conducted a cross-sectional survey of 951 HIV-infected adults receiving care at 14 HIV Research Network sites in 2003 to estimate associations between HRQOL and specific substance use among HIV-infected patients. HRQOL was assessed by multi-item measures of physical and role functioning, general health, pain, energy, positive affect, anxiety, and depression. Mental and physical summary scales were developed by factor analysis. We used linear regression to estimate adjusted associations between HRQOL and current illicit use of marijuana, analgesics, heroin, amphetamines, cocaine, sedatives, inhalants, hazardous/binge alcohol, and drug use severity. Current illicit drug use was reported by 37% of subjects. Mental HRQOL was reduced for current users [adjusted β coefficient −9.66, 95% confidence interval [(CI]) −13.4, −5.94] but not former users compared with never users. Amphetamines and sedatives were associated with large decreases in mental (amphetamines: β = −22.8 [95% CI −33.5, −12.0], sedatives: β = −18.6 [95% CI −26.2, −11.0]), and physical HRQOL (amphetamines: β = −11.5 [95% CI −22.6, −0.43], sedatives: β = −13.2 [95% CI −21.0, −5.36]). All illicit drugs were associated with decreased mental HRQOL: marijuana (β = −7.72 [95% CI −12.0, −3.48]), non-prescription analgesics (β = −13.4 [95% CI −20.8, −6.07]), cocaine (β = −10.5 [95% CI −16.4, −4.67]), and inhalants (β = −14.0 [95% CI −24.1, −3.83]). Facilitating sobriety for patients with attention to specific illicit drugs represents an important avenue for elevating HRQOL in patients living with HIV. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health-related quality of life
KW - HIV-infected patients
KW - substance use role
KW - chronic diseases
KW - 2008
KW - Chronicity (Disorders)
KW - Drug Abuse
KW - Health
KW - HIV
KW - Quality of Life
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290-01-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Grant: R01 AG026250. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Grant: K23 AA015313. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: K23-DA00523; K-23-DA019820. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, Health Services Research & Development Service, US. Other Details: Research Career Development Award. Recipients: Saha, Somnath
U1 - Sponsor: Robert Wood Johnson Foundation. Other Details: Generalist Physician Faculty Scholar Award. Recipients: No recipient indicated
U1 - Sponsor: Johns Hopkins. Other Details: Clinician Scientist Award. Recipients: Gebo, Kelly A.
DO - 10.1089/apc.2008.0005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17313-002&site=ehost-live&scope=site
UR - korthuis@ohsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18649-015
AN - 2008-18649-015
AU - Waehrer, Geetha M.
AU - Zaloshnja, Eduard
AU - Miller, Ted
AU - Galvin, Deborah
T1 - Substance-use problems: Are uninsured workers at greater risk?
JF - Journal of Studies on Alcohol and Drugs
JO - Journal of Studies on Alcohol and Drugs
JA - J Stud Alcohol Drugs
Y1 - 2008/11//
VL - 69
IS - 6
SP - 915
EP - 923
CY - US
PB - Alcohol Research Documentation
SN - 1937-1888
SN - 1938-4114
AD - Waehrer, Geetha M., Pacific Institute for Research and Evaluation, 11720 Beltsville Drive, Suite 900, Calverton, MD, US, 20705-3111
N1 - Accession Number: 2008-18649-015. PMID: 18925350 Other Journal Title: Journal of Studies on Alcohol; Quarterly Journal of Studies on Alcohol. Partial author list: First Author & Affiliation: Waehrer, Geetha M.; Pacific Institute for Research and Evaluation, Calverton, MD, US. Release Date: 20090209. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Abuse; Drug Usage; Employee Health Insurance; Health Care Seeking Behavior; Treatment Compliance. Minor Descriptor: Demographic Characteristics; Educational Attainment Level; Employee Assistance Programs; Employment Status; Income Level; Job Characteristics; Working Conditions. Classification: Substance Abuse & Addiction (3233); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2008.
AB - Objective: This study examined how problem drinking and drug use and their related treatment received by workers varied by health insurance coverage and employment characteristics. Method: We used National Survey on Drug Use and Health data on civilian workers ages 18 years and older from the 2002 and 2003 public-use files. Multivariate logistic regressions estimated the relationship between workers' uninsured status and problem use, dependence, and treatment while controlling for worker demographics, education, income, and job characteristics. Results: Controlling for differences in worker and workplace characteristics, uninsured workers were significantly more likely than privately insured workers to be illicit drug users or heavy drinkers. Among dependent workers, the lack of insurance was associated with a reduction in treatment received for problem drinkers (odds ratio = 0.31, p = .13). By contrast, a large, positive--albeit statistically nonsignificant--association between being uninsured and receiving treatment prevailed among uninsured workers using illicit drugs. Workplace substance-use policies were associated with a significant reduction in the odds of treatment received or treatment needed among problem drinkers without insurance coverage. Employee assistance programs were not good predictors of treatment received among uninsured workers. Conclusions: Uninsured workers were more likely to be heavy drinkers or illicit drug users than were workers with health insurance. Health insurance coverage was not significantly associated with treatment received among workers reporting problem use. Uninsured workers may be unable to benefit fully from employee assistance programs' treatment and referral services, whose utility depends on adequate behavioral health coverage for workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - problem drinking
KW - drug use
KW - treatment
KW - health insurance coverage
KW - employment characteristics
KW - worker demographics
KW - education
KW - income
KW - job & workplace characteristics
KW - 2008
KW - Alcohol Abuse
KW - Drug Usage
KW - Employee Health Insurance
KW - Health Care Seeking Behavior
KW - Treatment Compliance
KW - Demographic Characteristics
KW - Educational Attainment Level
KW - Employee Assistance Programs
KW - Employment Status
KW - Income Level
KW - Job Characteristics
KW - Working Conditions
KW - 2008
U1 - Sponsor: Center for Substance Abuse Prevention. Grant: 277-00-6103. Recipients: No recipient indicated
DO - 10.15288/jsad.2008.69.915
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18649-015&site=ehost-live&scope=site
UR - Waehrer@pire.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00407-011
AN - 2009-00407-011
AU - Badura, Maribeth
AU - Johnson, Kay
AU - Hench, Karen
AU - Reyes, Madelyn
T1 - Healthy start: Lessons learned on interconception care.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2008/11//Nov-Dec, 2008
VL - 18
IS - 6,Suppl
SP - S61
EP - S66
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Badura, Maribeth, Division of Healthy Start & Perinatal Services, Matemal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Parklawn Building, 5600 Fishers Lane, Room 18-05, Rockville, MD, US, 20857
N1 - Accession Number: 2009-00407-011. Partial author list: First Author & Affiliation: Badura, Maribeth; U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Division of Healthy Start and Perinatal Services, Rockville, MD, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Mortality Rate; Primary Health Care. Minor Descriptor: Government Programs; Infant Development; Prenatal Care. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Nov-Dec, 2008. Publication History: Accepted Date: Jul 25, 2008; First Submitted Date: Jul 8, 2008. Copyright Statement: The Jacobs Institute of Women's Health. 2008.
AB - The Federal Healthy Start program was started in 1991 to address the factors that contribute to the Nation's high infant mortality rate, particularly among populations with disproportionately high rates of adverse perinatal health outcomes. The goals of Healthy Start are to reduce disparities in access to and utilization of health services by using a lifespan approach, improving the local health care system, and increasing consumer and community input into health care decisions. In 2007, Healthy Start served 99 communities in 38 states, the District of Columbia, and Puerto Rico. Most Healthy Start grantees are nonprofit organizations. Since 2005, all 97 Healthy Start grantees (and the 2 additional grantees funded in 2007) have been required to include an interconception care component. Three quarters of grantees enrolled the majority of their interconception clients during the prenatal period. Most grantees used care coordination and case management as the primary approach to improving interconception health care. In 2007, 93 interconception projects reported that 9 out of 10 women had an ongoing source of primary care. Grantees screened to detect health conditions and risks, as well as provided an opportunity to provide vital information to women about their risks for chronic conditions such as obesity, hypertension, and diabetes. The Healthy Start interconception components demonstrate a critical need for and the potential impact of a strong interconception care program for high-risk populations such as women living in poverty, in medically underserved communities, and without health coverage. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - infant mortality rate
KW - prenatal care
KW - health care services
KW - primary health care
KW - 2008
KW - Health Care Services
KW - Mortality Rate
KW - Primary Health Care
KW - Government Programs
KW - Infant Development
KW - Prenatal Care
KW - 2008
DO - 10.1016/j.whi.2008.07.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00407-011&site=ehost-live&scope=site
UR - mbadura@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17639-008
AN - 2009-17639-008
AU - Bertens, Madelief G. B. C.
AU - Wolfers, Mireille E. G.
AU - van den Borne, Bart
AU - Schaalma, Herman P.
T1 - Negotiating safe sex among women of Afro-Surinamese and Dutch Antillean descent in the Netherlands.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2008/11//
VL - 20
IS - 10
SP - 1211
EP - 1216
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - Schaalma, Herman P., Faculty of Psychology, Maastricht University, Maastricht, Netherlands
N1 - Accession Number: 2009-17639-008. PMID: 19012082 Partial author list: First Author & Affiliation: Bertens, Madelief G. B. C.; Department of Health Education and Health Promotion, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands. Release Date: 20100222. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; Human Females; Negotiation; Safe Sex. Minor Descriptor: Regional Differences. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Female (40). Location: Netherlands. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2008. Copyright Statement: Taylor & Francis. 2008.
AB - Safe sex negotiation and communication about sexual risks with partners is important for women to ensure sexual risk reduction. This paper describes the results of a survey on safer sex and negotiation behavior, and the correlates of negotiation with partners among 128 women from Surinamese and Dutch Antillean descent in the Netherlands. The key findings are that 50% of the participants had negotiated sexual risk reduction with their partner, yet only 40% of the women who negotiated safer sex actually claimed practicing safe sex. Participants defined safe sex with steady partners primarily as negotiated safety and monogamy, and safe sex with casual partners primarily as condom use. Intentions to negotiate safer sex with steady partners were related to positive attitudes and perceived injunctive norms towards safe sex negotiation, and educational background. Intention to discuss safe sex with casual partners were primarily related to attitudes and perceived self-efficacy. STI/HIV prevention interventions targeting these women should incorporate awareness-raising of safety in different types of relationships, deciding on the appropriateness of relation-specific sexual risk reduction strategies, and building negotiation skills to accomplish the realization of these strategies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - safe sex
KW - Afro-Surinamese women
KW - Dutch Antillean women
KW - Netherlands
KW - negotiation
KW - AIDS prevention
KW - 2008
KW - AIDS Prevention
KW - Human Females
KW - Negotiation
KW - Safe Sex
KW - Regional Differences
KW - 2008
DO - 10.1080/09540120802009070
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17639-008&site=ehost-live&scope=site
UR - herman.schaalma@psychology.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17365-002
AN - 2008-17365-002
AU - Coffey, Rosanna M.
AU - Buck, Jeffrey A.
AU - Kassed, Cheryl A.
AU - Dilonardo, Joan
AU - Forhan, Carol
AU - Marder, William D.
AU - Vandivort-Warren, Rita
T1 - Transforming mental health and substance abuse data systems in the United States.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/11//
VL - 59
IS - 11
SP - 1257
EP - 1263
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Coffey, Rosanna M., Thomson Reuters, 4301 Connecticut Ave., Washington, DC, US, 20008
N1 - Accession Number: 2008-17365-002. PMID: 18971401 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Coffey, Rosanna M.; Thomson Reuters, Washington, DC, US. Release Date: 20090202. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Psychology; Initiative; Medicaid; Mental Health Services; Health Care Policy. Minor Descriptor: Health Insurance; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 7. Issue Publication Date: Nov, 2008.
AB - State efforts to improve mental health and substance abuse service systems cannot overlook the fragmented data systems that reinforce the historical separateness of systems of care. These separate systems have discrete approaches to treatment, and there are distinct funding streams for state mental health, substance abuse, and Medicaid agencies. Transforming mental health and substance abuse services in the United States depends on resolving issues that underlie separate treatment systems--access barriers, uneven quality, disjointed coordination, and information silos across agencies and providers. This article discusses one aspect of transformation--the need for interoperable information systems. It describes current federal and state initiatives for improving data interoperability and the special issue of confidentiality associated with mental health and substance abuse treatment data. Some achievable steps for states to consider in reforming their behavioral health data systems are outlined. The steps include collecting encounter-level data; using coding that is compliant with the Health Insurance Portability and Accountability Act, including national provider identifiers; forging linkages with other state data systems and developing unique client identifiers among systems; investing in flexible and adaptable data systems and business processes; and finding innovative solutions to the difficult confidentiality restrictions on use of behavioral health data. Changing data systems will not in itself transform the delivery of care; however, it will enable agencies to exchange information about shared clients, to understand coordination problems better, and to track successes and failures of policy decisions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health
KW - substance abuse data systems
KW - medicaid agencies
KW - treatment systems
KW - care delivery
KW - health insurance
KW - confidentiality
KW - policy decisions
KW - 2008
KW - Health Care Psychology
KW - Initiative
KW - Medicaid
KW - Mental Health Services
KW - Health Care Policy
KW - Health Insurance
KW - Mental Health
KW - 2008
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, US. Grant: 270-01-7087. Other Details: Integrated Database Project; between Thomson Medstat (now Thomson Reuters) and two SAMHSA centers--the Center for Substance Abuse Treatment and the Center for Mental Health Services. Recipients: No recipient indicated
DO - 10.1176/appi.ps.59.11.1257
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17365-002&site=ehost-live&scope=site
UR - ORCID: 0000-0002-7198-6933
UR -
UR - rosanna.coffey@thomsonreuters.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16469-003
AN - 2008-16469-003
AU - Liang, Lan
AU - Huang, Jidong
T1 - Go out or stay in? The effects of zero tolerance laws on alcohol use and drinking and driving patterns among college students.
JF - Health Economics
JO - Health Economics
JA - Health Econ
Y1 - 2008/11//
VL - 17
IS - 11
SP - 1261
EP - 1275
CY - US
PB - John Wiley & Sons
SN - 1057-9230
SN - 1099-1050
AD - Liang, Lan, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2008-16469-003. PMID: 18219708 Partial author list: First Author & Affiliation: Liang, Lan; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20091012. Correction Date: 20130114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Alcohol Drinking Patterns; Blood Alcohol Concentration; Driving Behavior; Drug Laws. Minor Descriptor: Alcohols; College Students. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Nov, 2008. Publication History: Accepted Date: Oct 25, 2007; Revised Date: Oct 21, 2007; First Submitted Date: Aug 19, 2005. Copyright Statement: John Wiley & Sons, Ltd. 2008.
AB - Zero tolerance laws make it illegal per se for anyone under age 21 to drive with any measurable amount of blood alcohol. Although a link has been established between zero tolerance laws and lower motor vehicle fatalities, research has not produced strong evidence on how zero tolerance laws influence individual alcohol use and drinking and driving behaviors. Using a unique data set and a difference-in-difference-in-difference-type research design, we are able to analyze a number of pathways through which zero tolerance laws can work among an important underage population, college students. We find that zero tolerance laws reduce drinking and driving among college students. Further analysis of our detailed alcohol use measures suggests that zero tolerance laws are particularly effective at reducing the probability of driving after drinking for those who reported drinking away from home. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - zero tolerance laws
KW - alcohol use
KW - drinking patterns
KW - driving patterns
KW - college students
KW - 2008
KW - Alcohol Drinking Patterns
KW - Blood Alcohol Concentration
KW - Driving Behavior
KW - Drug Laws
KW - Alcohols
KW - College Students
KW - 2008
U1 - Sponsor: Robert Wood Johnson Foundation, Substance Use Policy Research Program. Grant: 046227. Other Details: University of Illinois at Chicago. Recipients: No recipient indicated
DO - 10.1002/hec.1321
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16469-003&site=ehost-live&scope=site
UR - lliang@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17365-007
AN - 2008-17365-007
AU - Shen, Ce
AU - Smyer, Michael
AU - Mahoney, Kevin J.
AU - Simon-Rusinowitz, Lori
AU - Shinogle, Judith
AU - Norstrand, Julie
AU - Mahoney, Ellen
AU - Schauer, Carole
AU - del Vecchio, Paolo
T1 - Consumer-directed care for beneficiaries with mental illness: Lessons from New Jersey's cash and counseling program.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/11//
VL - 59
IS - 11
SP - 1299
EP - 1306
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Shen, Ce, Graduate School of Social Work, Boston College, 140 Commonwealth Ave., Chestnut Hill, MA, US, 02467
N1 - Accession Number: 2008-17365-007. PMID: 18971406 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Shen, Ce; Graduate School of Social Work, Boston College, Chestnut Hill, MA, US. Release Date: 20090202. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Diagnosis; Evaluation; Mental Disorders; Mental Health Services. Minor Descriptor: Caregivers; Health; Health Care Delivery. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2008.
AB - Objective: Previous research from the Cash and Counseling Demonstration and Evaluation (CCDE) programs in New Jersey, Arkansas, and Florida suggests that consumers' control over personal care greatly improves their satisfaction with care arrangements and their outlook on life. Still, some argue that consumer-directed care may not be appropriate for consumers with a diagnosis of mental illness. This study examined the effectiveness of the CCDE program for those with a diagnosis of mental illness. Methods: This study examined nonelderly Medicaid beneficiaries in New Jersey with a diagnosis of mental illness and compared and contrasted the experiences of those in New Jersey's CCDE program (N = 109) and those who received services provided by an agency (N = 119). Logistic regression analyses were performed on baseline and nine-month follow-up data. Results: By examining outcome measures--including satisfaction with care arrangements, consumers' perceptions of paid caregivers' attitudes, unmet needs, adverse events, and satisfaction with life--this study offers evidence that, from the perspective of consumers, the CCDE program is appropriate for participants with a mental illness diagnosis. For most outcome measures the CCDE program demonstrated a positive effect after baseline characteristics were controlled for. The analysis of measures of adverse events, health problems, and general health status did not yield statistically significant differences between the control group and the treatment group, indicating that CCDE care was at least as safe as agency-directed care. Conclusions: Considering the growing need for long-term care services and the limited resources available, a consumer-directed option can be a valuable alternative for persons with a diagnosis of mental illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consumer-directed care
KW - beneficiaries
KW - mental illness
KW - counseling program
KW - long-term care services
KW - diagnosis
KW - 2008
KW - Counseling
KW - Diagnosis
KW - Evaluation
KW - Mental Disorders
KW - Mental Health Services
KW - Caregivers
KW - Health
KW - Health Care Delivery
KW - 2008
U1 - Sponsor: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, US. Grant: 06M000133. Recipients: No recipient indicated
DO - 10.1176/appi.ps.59.11.1299
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17365-007&site=ehost-live&scope=site
UR - shenc@bc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17365-021
AN - 2008-17365-021
AU - Fletcher, Kenneth E.
T1 - Review of Handbook of psychiatric measures, 2nd edition.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/11//
VL - 59
IS - 11
SP - 1351
EP - 1351
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2008-17365-021. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Fletcher, Kenneth E.; Center for Mental Health Services, University of Massachusetts, Medical School, Worcester, MA, US. Release Date: 20090202. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Clinical Practice; Clinicians; Psychiatric Evaluation; Psychometrics. Classification: Clinical Psychological Testing (2224); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Rush, A. John JR (Ed); First, Michael B. (Ed); Blacker, Deborah (Ed). Handbook of psychiatric measures, 2nd edition=Washington, D.C., American Psychiatric Publishing, Inc., 828 pages, $195, CD-ROM included; 2008. Page Count: 1. Issue Publication Date: Nov, 2008.
AB - Reviews the book, Handbook of psychiatric measures, 2nd edition edited by A. John Rush Jr., Michael B. First, and Deborah Blacker (see record [rid]2007-19696-000[/rid]). A few changes are evident in the second edition of this handbook. Authors of each section reevaluated each measure included in the original edition and added other measures considered to be used frequently in clinical practice or research. Some measures were added because they are briefer instruments with acceptable psychometric properties. All of the chapters have been updated based on the most currently available information, including contact information. The CD that accompanies the second edition may be something of a disappointment to those who are familiar with the first-edition CD. The combination of the text and CD is still a good investment and a useful resource for clinicians, researchers, students, and policy makers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric measures
KW - psychometric properties
KW - clinical practice
KW - clinicians
KW - 2008
KW - Clinical Practice
KW - Clinicians
KW - Psychiatric Evaluation
KW - Psychometrics
KW - 2008
U2 - Rush, A. John JR (Ed); First, Michael B. (Ed); Blacker, Deborah (Ed). (2008); Handbook of psychiatric measures, 2nd edition; Washington, D.C., American Psychiatric Publishing, Inc., 828 pages, $195, CD-ROM included
DO - 10.1176/appi.ps.59.11.1351
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17365-021&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16550-001
AN - 2008-16550-001
AU - Owens, Michelle D.
AU - Beckles, Gloria L. A.
AU - Ho, Karen Kar-Yee
AU - Gorrell, Paul
AU - Brady, Jeffrey
AU - Kaftarian, Jackie Shakeh
T1 - Women with diagnosed diabetes across the life stages: Underuse of recommended preventive care services.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2008/11//
VL - 17
IS - 9
SP - 1415
EP - 1423
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Owens, Michelle D., Centers for Disease Control and Prevention, Division of Diabetes Translation, 4770 Buford Highway, NE, Mailstop K-10, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-16550-001. PMID: 18954234 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Owens, Michelle D.; Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20100614. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Diagnosis; Health Care Utilization; Life Span; Preventive Medicine. Minor Descriptor: Health Care Services; Human Females; Socioeconomic Status. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Medical Expenditure Panel Survey; National Health and Nutrition Examination Survey; National Health Interview Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2008. Copyright Statement: Mary Ann Liebert, Inc.
AB - Diabetes is a common and costly disease. In 2007, an estimated 24 million people in the United States had diabetes, with almost half of these being women. Diabetes increases the risk of morbidity and mortality from several conditions, including cardiovascular disease, several types of cancers, influenza and pneumococcal infection, and kidney, eye, and periodontal diseases. The aim of this study was to examine the quality of care that women with diabetes receive and to assess how receipt of some clinical preventive services and screening for common conditions associated with diabetes vary according to socioeconomic factors. Our findings indicate that use of diabetes-specific preventive care among women is low, with the youngest women (≤45 years) and those with low educational levels being the least likely to receive the recommended services. Women with diabetes were less likely than women without diabetes to receive a Pap smear, with the oldest women (≥65 years) being the most vulnerable. Women with diabetes who were poor and nonwhite were less likely than more affluent and white women to receive a pneumococcal vaccination. This study's findings suggest that having a chronic disease may serve as a barrier to the receipt of recommended preventive care among women. Effective interventions should be designed to meet the needs of the most vulnerable women with diabetes, in particular, those who are at the extremes of the life cycle, are poor, and have low levels of education. Programs should use a life stage approach to address the unique needs of women with diabetes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women
KW - diagnosis
KW - diabetes
KW - life stages
KW - preventive care services
KW - socioeconomic factors
KW - service recommendation
KW - health care utilization
KW - 2008
KW - Diabetes
KW - Diagnosis
KW - Health Care Utilization
KW - Life Span
KW - Preventive Medicine
KW - Health Care Services
KW - Human Females
KW - Socioeconomic Status
KW - 2008
DO - 10.1089/jwh.2008.1125
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16550-001&site=ehost-live&scope=site
UR - MOwens1@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15292-005
AN - 2008-15292-005
AU - Signore, Caroline
AU - Aros, Sofía
AU - Morrow, Jason D.
AU - Troendle, James
AU - Conley, Mary R.
AU - Flanigan, Elizabeth Y.
AU - Cassorla, Fernando
AU - Mills, James L.
T1 - Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking ≥48 g of alcohol per day.
JF - Alcoholism: Clinical and Experimental Research
JO - Alcoholism: Clinical and Experimental Research
JA - Alcohol Clin Exp Res
Y1 - 2008/11//
VL - 32
IS - 11
SP - 1893
EP - 1898
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0145-6008
SN - 1530-0277
AD - Mills, James L., NIH/NICHD, Building 6100, Rm 7B03, Bethesda, MD, US, 20892
N1 - Accession Number: 2008-15292-005. PMID: 18715278 Partial author list: First Author & Affiliation: Signore, Caroline; Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091019. Correction Date: 20130401. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Pregnancy; Prostaglandins; Stress; Vasoconstriction. Minor Descriptor: Etiology. Classification: Physiological Psychology & Neuroscience (2500). Population: Human (10); Female (40). Location: Chile. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Wechsler Preschool and Primary Scale of Intelligence; Bayley Scales of Infant Development; Wechsler Intelligence Scale for Children. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2008. Publication History: Accepted Date: Jun 17, 2008; First Submitted Date: Feb 1, 2008. Copyright Statement: Research Society on Alcoholism. 2008.
AB - Background: The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy. Methods: Pregnant women consuming ≥48 g alcohol per day (n = 29) on average and pregnant women who abstained from alcohol use (n = 39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2α, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1α (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine. Results: In crude analyses, there was no significant difference in 8-isoprostane F2α between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg creatinine, respectively, p = 0.87). There were no significant differences between the drinking and nondrinking groups in levels of 2,3-dinor-6-keto-prostaglandin F1α (1.03 vs. 1.17 ng/mg creatinine, repectively, p = 0.50), 11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng/mg creatinine, respectively, p = 0.21), or the ratio of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p = 0.14). Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not substantially alter the results. Conclusion: Our results show no difference in levels of urinary eicosanoid markers of oxidative stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant women who abstain. These findings speak against a role for maternal oxidative stress or systemic vasoconstriction in the pathogenesis of alcohol damage to the fetus. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oxidative stress
KW - systemic vasoconstriction
KW - pregnant women drinking
KW - pathogenesis
KW - 2008
KW - Pregnancy
KW - Prostaglandins
KW - Stress
KW - Vasoconstriction
KW - Etiology
KW - 2008
U1 - Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Intramural Research Program, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: GM15431; DK48831; ES131 25. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15292-005&site=ehost-live&scope=site
UR - MillsJ@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15003-010
AN - 2008-15003-010
AU - Yu, Stella M.
AU - Huang, Zhihuan J.
AU - Kogan, Michael D.
T1 - State-level health care access and use among children in US immigrant families.
T3 - Health without borders
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/11//
VL - 98
IS - 11
SP - 1996
EP - 2003
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Yu, Stella M., Maternal and Child Health Bureau, 5600 Fishers Lane, 18A-55, Rockville, MD, US, 20857
N1 - Accession Number: 2008-15003-010. PMID: 18799781 Partial author list: First Author & Affiliation: Yu, Stella M.; Maternal and Child Health Bureau, HRSA, Rockville, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Huang, Zhihuan J. Major Descriptor: Family; Health Care Services; Immigration. Minor Descriptor: Victimization. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov, 2008. Publication History: Accepted Date: Mar 24, 2008.
AB - Objectives: We examined the association between children’s state of residence and their access to health care among specific types of immigrant families: foreign-born children, US-born children with 1 foreign-born parent, US-born children with both foreign-born parents, and nonimmigrant families. Methods: We analyzed data from 12400 children from the 2003 National Survey of Children’s Health in the 6 states with the highest proportion of immigrants (California, Florida, Illinois, New York, New Jersey, and Texas). Results: Multivariable analyses indicated that among foreign-born children, those living in California, Illinois, and Texas were more likely to lack access to health care compared with those living in New York. Among foreign-born children with 1 or 2 US-born parents, Texas children were most likely to lack health insurance. Within nonimmigrant families, children from California, Florida, and Texas had significantly more access and use problems. Conclusions: Our findings document differential health care access and use among states for specific immigrant family types. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state level health care access
KW - health care use
KW - US immigrant families
KW - children residence state
KW - 2008
KW - Family
KW - Health Care Services
KW - Immigration
KW - Victimization
KW - 2008
U1 - Sponsor: Maternal and Child Health Bureau, Office of Data and Program Development, US. Other Details: Intergovernmental Personnel Act Agreement. Recipients: Huang, Zhihuan J.
DO - 10.2105/AJPH.2007.117911
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15003-010&site=ehost-live&scope=site
UR - syu@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-15003-019
AN - 2008-15003-019
AU - Roubideaux, Yvette
AU - Noonan, Carolyn
AU - Goldberg, Jack H.
AU - Valdez, S. Lorraine
AU - Brown, Tammy L.
AU - Manson, Spero M.
AU - Acton, Kelly
T1 - Relation between the level of American Indian and Alaska Native diabetes education program services and quality-of-care indicators.
T3 - Health without borders
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/11//
VL - 98
IS - 11
SP - 2079
EP - 2084
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Roubideaux, Yvette, College of Medicine, University of Arizona, 500 N Tucson Blvd, #110, Tucson, AZ, US, 85716
N1 - Accession Number: 2008-15003-019. PMID: 18511737 Partial author list: First Author & Affiliation: Roubideaux, Yvette; Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Health; Health Education; Quality of Care. Minor Descriptor: Alaska Natives; American Indians; Client Characteristics; Educational Programs. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2008. Publication History: Accepted Date: Oct 16, 2007.
AB - Objectives: We examined the relation between the level of diabetes education program services in the Indian Health Service (IHS) and indicators of the quality of diabetes care to determine if more-comprehensive diabetes services were associated with better quality of diabetes care. Methods: In this cross-sectional study, we used the IHS Integrated Diabetes Education Recognition Program to rank program services into 1 of 3 levels of comprehensiveness, ranging from lowest (developmental) to highest (integrated). We compared quality-of-care indicators among programs of differing levels with the 2001 IHS Diabetes Care and Outcomes Audit. Quality indicators included patients having recommended yearly examinations, education, and laboratory tests and achieving recommended levels of intermediate outcomes of care. Results: Most of the 86 participating programs were classified at or below the developmental level; only 9 programs (11%) were ranked at higher levels. After adjusting for patient characteristics, program factors, and correlation of patients within programs, we associated programs that were more comprehensive with higher completion rates of yearly lipid and hemoglobin A1C tests (P < .05). Conclusions: System-wide improvements in diabetes education are associated with better diabetes care. The results can help inform the development of diabetes education programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indian
KW - Alaska Native
KW - diabetes education program services
KW - quality of care indicators
KW - diabetes care
KW - 2008
KW - Diabetes
KW - Health
KW - Health Education
KW - Quality of Care
KW - Alaska Natives
KW - American Indians
KW - Client Characteristics
KW - Educational Programs
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: P01 HS10854. Recipients: No recipient indicated
U1 - Sponsor: National Center on Minority Health and Health Disparities, US. Grant: P60 MD000507. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Grant: P30 AG1 5297. Recipients: No recipient indicated
DO - 10.2105/AJPH.2007.110478
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-15003-019&site=ehost-live&scope=site
UR - yvetter@u.arizona.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16275-017
AN - 2008-16275-017
AU - Charles, Luenda E.
AU - Burchfie, Cecil M.
AU - Violanti, John M.
AU - Fekedulegn, Desta
AU - Slaven, James E.
AU - Browne, Richard W.
AU - Hartley, Tara A.
AU - Andrew, Michael E.
T1 - Adiposity measures and oxidative stress among police officers.
JF - Obesity
JO - Obesity
JA - Obesity (Silver Spring)
Y1 - 2008/11//
VL - 16
IS - 11
SP - 2489
EP - 2497
CY - United Kingdom
PB - Nature Publishing Group
SN - 1930-7381
SN - 1930-739X
AD - Charles, Luenda E.
N1 - Accession Number: 2008-16275-017. PMID: 18719659 Other Journal Title: Obesity Research. Partial author list: First Author & Affiliation: Charles, Luenda E.; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Other Publishers: North American Assn for the Study of Obesity (NAASO); Wiley-Blackwell Publishing Ltd. Release Date: 20091102. Correction Date: 20130218. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Police Personnel; Oxidative Stress. Minor Descriptor: Ascorbic Acid; Antioxidants. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2008. Publication History: First Posted Date: Aug 21, 2008; Accepted Date: May 13, 2008; First Submitted Date: Feb 6, 2008. Copyright Statement: The Obesity Society. 2008.
AB - Our objective was to investigate associations between adiposity measures (BMI, waist circumference, waist-to-hip ratio, waist-to-height ratio, and abdominal height) and biomarkers of oxidative stress (glutathione (GSH), GSH peroxidase (GSH-Px), vitamin C, thiobarbituric acid reactive substances (TBARS), and trolox equivalent antioxidant capacity (TEAC)) among police officers. This cross-sectional study included randomly selected police officers (43 policewomen; 67 policemen) from Buffalo, New York. Adiposity measures were performed using standardized methods. Biomarkers were measured on fasting blood specimens. An oxidative stress score (OSS) was created as a composite of the biomarkers. ANOVAs were used to compare mean levels of biomarkers across tertiles of the adiposity measures. Officers were 26- to 61-years old. GSH was inversely associated with waist circumference (trend P = 0.030) and waist-to-hip ratio (trend P = 0.026). GSH-Px was inversely associated with BMI (trend P = 0.004) and with waist-to-height ratio (trend P = 0.017). No associations were observed for TEAC, TBARS, or OSS with any adiposity measure. Significant interactions were observed by physical activity status for GSH with waist circumference and waist-to-hip ratio and for vitamin C with waist circumference, waist-to-hip and waist-to-height ratios. The above associations were inversely related only among officers who reported engaging in physical activity. Inverse associations were observed for BMI and waist circumference with GSH, but only among women; the interaction with gender was significant. Larger indices of adiposity were associated with increased levels of oxidative stress and decreased levels of antioxidant defense. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adiposity measures
KW - oxidative stress
KW - police officers
KW - peroxidase
KW - vitamin C
KW - thiobarbituric acid reactive substances
KW - trolox equivalent antioxidant capacity
KW - 2008
KW - Police Personnel
KW - Oxidative Stress
KW - Ascorbic Acid
KW - Antioxidants
KW - 2008
DO - 10.1038/oby.2008.395
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16275-017&site=ehost-live&scope=site
UR - lcharles@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-15076-020
AN - 2011-15076-020
AU - Liu, Zhong-Hua
AU - Shin, Rick
AU - Ikemoto, Satoshi
T1 - Dual role of medial A10 dopamine neurons in affective encoding.
JF - Neuropsychopharmacology
JO - Neuropsychopharmacology
JA - Neuropsychopharmacology
Y1 - 2008/11//
VL - 33
IS - 12
SP - 3010
EP - 3020
CY - United Kingdom
PB - Nature Publishing Group
SN - 0893-133X
SN - 1740-634X
AD - Ikemoto, Satoshi, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD, US, 21224
N1 - Accession Number: 2011-15076-020. PMID: 18256592 Partial author list: First Author & Affiliation: Liu, Zhong-Hua; Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD, US. Release Date: 20111107. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dopamine; Neurons; Quinpirole. Minor Descriptor: Food; Rats; Rewards. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Nov, 2008. Publication History: First Posted Date: Feb 6, 2008; Accepted Date: Jan 2, 2008; Revised Date: Dec 26, 2007; First Submitted Date: Oct 24, 2007. Copyright Statement: All rights reserved. Nature Publishing Group. 2008.
AB - Increasing evidence suggests that the activation of medial A10 neurons mediates positive affective encoding. However, little is known about the functions of the inhibition of midbrain dopamine neurons. Here we show evidence suggesting that the inhibition of medial A10 neurons mediates a negative affective state, leading to negative affective encoding, whereas blunting the activation of medial A10 neurons disrupts positive affective encoding involving food reward. We used a microinjection procedure, in which the D₂ dopamine receptor agonist quinpirole was administered into the cell body region of the dopamine neurons, a procedure that reduces dopamine cell firing. Microinjections of quinpirole into the posteromedial ventral tegmental area, but not its more lateral counterparts, led to conditioned place aversion. Quinpirole administration to this site also decreased food intake and basal dopamine concentration in the ventromedial striatum, a major projection area of medial A10 neurons. In addition, moderate quinpirole doses that did not lead to conditioned place aversion or disrupt food intake abolished food-conditioned place preference, suggesting that blunting dopamine impulse activity in response to food reward disrupts positive affective encoding in associated external stimuli. Our data support the hypothesis that activation of medial A10 dopamine neurons mediates a positive affective state, leading to positive affective encoding, while their inhibition mediates a negative affective state, leading to negative affective encoding. Together with previous findings, we propose that medial A10 neurons are an important component of the mechanism via which animals learn to avoid negative incentive stimuli. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dopamine
KW - neurons
KW - affective encoding
KW - food rewards
KW - quinpirole
KW - rats
KW - 2008
KW - Dopamine
KW - Neurons
KW - Quinpirole
KW - Food
KW - Rats
KW - Rewards
KW - 2008
U1 - Sponsor: National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, US. Recipients: No recipient indicated
DO - 10.1038/npp.2008.4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-15076-020&site=ehost-live&scope=site
UR - ORCID: 0000-0002-0732-7386
UR -
UR - sikemoto@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-19323-011
AN - 2008-19323-011
AU - Pezzin, Liliana E.
AU - Pollak, Robert A.
AU - Scheme, Barbara Steinberg
T1 - Parental marital disruption, family type, and transfers to disabled elderly parents.
JF - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JO - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JA - J Gerontol B Psychol Sci Soc Sci
Y1 - 2008/11//
VL - 63
IS - 6
SP - S349
EP - S358
CY - US
PB - Gerontological Society of America
SN - 1079-5014
SN - 1758-5368
AD - Pezzin, Liliana E., Department of Medicine and Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI, US, 53226
N1 - Accession Number: 2008-19323-011. PMID: 19092044 Partial author list: First Author & Affiliation: Pezzin, Liliana E.; Medicine and Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI, US. Other Publishers: Oxford University Press. Release Date: 20090209. Correction Date: 20160912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Family; Intergenerational Relations; Living Arrangements; Marital Status; Parents. Minor Descriptor: Adult Offspring; Aging; Money. Classification: Childrearing & Child Care (2956). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Nov, 2008.
AB - Objectives: The objective of this study was to investigate the effect of parental marital status, marital history, and family type on inter generational living arrangements and adult children's time and cash transfers to their unpartnered disabled elderly parents. Methods: We used data from the Asset and Health Dynamics Among the Oldest Old survey to estimate the joint probabilities that an adult child provides time and/or cash transfers to a parent and to analyze a five-level categorical variable capturing parent-child living arrangements. Results: The estimates suggest significant detrimental effects of parental divorce and step relationship on time transfers and on the probability of coresidence with the index child. Family type, as captured by the composition of the index child's sibling network according to kin relationship to the parent, also affected transfers and living arrangement choices of adult children. Discussion: The findings that transfers from adult children to their unpartnered disabled elderly parents depend on parental marital status and kin relationship suggest that changing family patterns are altering the traditional role of the family as a support network. These findings raise concerns about the care likely to be available to future cohorts of elderly persons who will have experienced substantially higher rates of divorce, remarriage, and step parenthood than the cohort considered in this study. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parental marital status
KW - marital history
KW - family type
KW - intergenerational living arrangements
KW - adult children
KW - disabled elderly parents
KW - cash transfers
KW - 2008
KW - Family
KW - Intergenerational Relations
KW - Living Arrangements
KW - Marital Status
KW - Parents
KW - Adult Offspring
KW - Aging
KW - Money
KW - 2008
U1 - Sponsor: National Institute on Aging, US. Grant: 1 R01 AG24049; R01 AG025475. Recipients: No recipient indicated
DO - 10.1093/geronb/63.6.S349
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-19323-011&site=ehost-live&scope=site
UR - lpezzin@mcw.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17893-006
AN - 2008-17893-006
AU - Meyer, Douglas A.
AU - Richer, Edmond
AU - Benkovic, Stanley A.
AU - Hayashi, Kanehiro
AU - Kansy, Janice W.
AU - Hale, Carly F.
AU - Moy, Lily Y.
AU - Kim, Yong
AU - O'Callaghan, James P.
AU - Tsai, Li-Huei
AU - Greengard, Paul
AU - Nairn, Angus C.
AU - Cowan, Christopher W.
AU - Miller, Diane B.
AU - Antich, Pietro
AU - Bibb, James A.
T1 - Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology.
JF - PNAS Proceedings of the National Academy of Sciences of the United States of America
JO - PNAS Proceedings of the National Academy of Sciences of the United States of America
JA - Proc Natl Acad Sci U S A
Y1 - 2008/11//
VL - 105
IS - 47
SP - 18561
EP - 18566
CY - US
PB - National Academy of Sciences
SN - 0027-8424
SN - 1091-6490
AD - Bibb, James A., Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, US, 75390-9070
N1 - Accession Number: 2008-17893-006. PMID: 19017804 Partial author list: First Author & Affiliation: Meyer, Douglas A.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, US. Release Date: 20090126. Correction Date: 20170123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Meyer, Douglas A. Major Descriptor: Cocaine; Dendrites; N-Methyl-D-Aspartate; Perceptual Motor Learning; Striatum. Minor Descriptor: Dopamine; Hippocampus; Mice; Neurons; Neurotransmission; Visual Cortex. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2008.
AB - Motor learning and neuro-adaptations to drugs of abuse rely upon neuronal signaling in the striatum. Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopamine neurotransmission and behavioral responses to cocaine. Although the role for Cdk5 in neurodegeneration in the cortex and hippocampus and in hippocampal-dependent learning has been demonstrated, its dysregulation in the striatum has not been examined. Here we show that strong activation of striatal NMDA receptors produced p25, the truncated form of the Cdk5 co-activator p35. Furthermore, inducible overexpression of p25 in the striatum prevented locomotor sensitization to cocaine and attenuated motor coordination and learning. This corresponded with reduced dendritic spine density, increased neuro-inflammation, altered dopamine signaling, and shifted Cdk5 specificity with regard to physiological and aberrant substrates, but no apparent loss of striatal neurons. Thus, dysregulation of Cdk5 dramatically affects striatal-dependent brain function and may be relevant to non-neurodegenerative disorders involving dopamine neurotransmission. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - striatal dysregulation
KW - cyclin-dependent kinase 5
KW - locomotor responses
KW - cocaine
KW - motor learning
KW - dendritic morphology
KW - N-methyl-D-aspartate
KW - mice
KW - 2008
KW - Cocaine
KW - Dendrites
KW - N-Methyl-D-Aspartate
KW - Perceptual Motor Learning
KW - Striatum
KW - Dopamine
KW - Hippocampus
KW - Mice
KW - Neurons
KW - Neurotransmission
KW - Visual Cortex
KW - 2008
U1 - Sponsor: Basic Science Training Program in Drug Abuse. Grant: T32-DA7290. Recipients: Meyer, Douglas A.
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: DA16672. Recipients: Bibb, James A.
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: DA10044. Recipients: Greengard, Paul; Nairn, Angus C.
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH079710-0. Recipients: Bibb, James A.
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH074866. Recipients: Greengard, Paul; Nairn, Angus C.
U1 - Sponsor: National Heart, Lung, and Blood Institute, US. Grant: HL077101. Recipients: Bibb, James A.
U1 - Sponsor: Whitehall Foundation. Recipients: Cowan, Christopher W.
U1 - Sponsor: Picower Foundation. Recipients: Greengard, Paul
U1 - Sponsor: Howard Hughes Medical Institute. Other Details: Generation of the p25-GFP mouse line and feasibility studies. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: NS051874. Recipients: Tsai, Li-Huei
DO - 10.1073/pnas.0806078105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17893-006&site=ehost-live&scope=site
UR - ORCID: 0000-0002-7075-0195
UR -
UR - james.bibb@utsouthwestern.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Levit, Katharine R.
AU - Kassed, Cheryl A.
AU - Coffey, Rosanna M.
AU - Mark, Tami L.
AU - Stranges, Elizabeth M.
AU - Buck, Jeffrey A.
AU - Vandivort-Warren, Rita
T1 - Future Funding For Mental Health And Substance Abuse: Increasing Burdens For The Public Sector.
JO - Health Affairs
JF - Health Affairs
Y1 - 2008/11/02/Nov2008 Supplement
VL - 27
IS - 6
M3 - Article
SP - w513
EP - w522
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Spending on mental health (MH) and substance abuse (SA) treatment is expected to double between 2003 and 2014, to $239 billion, and is anticipated to continue falling as a share of all health spending. By 2014, our projections of SA spending show increasing responsibility for state and local governments (45 percent); deteriorating shares financed by private insurance (7 percent); and 42 percent of SA spending going to specialty SA centers. For MH, Medicaid is forecasted to fund an increasingly larger share of treatment costs (27 percent), and prescription medications are expected to capture 30 percent of MH spending by 2014. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health
KW - FINANCE
KW - SUBSTANCE abuse -- Treatment
KW - MEDICAL care costs
KW - HEALTH insurance
KW - FEDERAL aid to health planning
KW - PUBLIC sector
KW - LOCAL government
KW - STATE governments
KW - PUBLIC spending
N1 - Accession Number: 36097656; Levit, Katharine R. 1; Email Address: Katharine.Levit@thomsonreuters.com Kassed, Cheryl A. 1 Coffey, Rosanna M. 2 Mark, Tami L. 3 Stranges, Elizabeth M. 4 Buck, Jeffrey A. 5 Vandivort-Warren, Rita 6; Affiliation: 1: Senior Research Leader, Health Care Business of Thomson Reuters, Washington, D.C. 2: Vice President, Health Care Business of Thomson Reuters, Washington, D.C. 3: Director, Health Care Business of Thomson Reuters, Washington, D.C. 4: Analytic Consultant, Health Care Business, Thomson Reuters, Evanston, Illinois 5: Chief of the Survey, Analysis, and Financing Branch, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland 6: Public Health Analyst, Quality Assurance and Workforce, Center for Substance Abuse Treatment, SAMHSA, Rockville, Maryland; Source Info: Nov2008 Supplement, Vol. 27 Issue 6, pw513; Subject Term: MENTAL health; Subject Term: FINANCE; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: MEDICAL care costs; Subject Term: HEALTH insurance; Subject Term: FEDERAL aid to health planning; Subject Term: PUBLIC sector; Subject Term: LOCAL government; Subject Term: STATE governments; Subject Term: PUBLIC spending; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); Number of Pages: 10p; Document Type: Article
L3 - 10.1377/hlthaff.27.6.w513
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36097656&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105574045
T1 - A call to action: public health and community college partnerships to educate the workforce and promote health equity.
AU - Honoré PA
AU - Graham GN
AU - Garcia J
AU - Morris W
Y1 - 2008/11/02/2008 Supplement
N1 - Accession Number: 105574045. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2008 Supplement. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9505213.
KW - Personnel Shortage
KW - Public Health
KW - Workforce
KW - Colleges and Universities
KW - Public Health -- Education
KW - United States
SP - S82
EP - 4
JO - Journal of Public Health Management & Practice
JF - Journal of Public Health Management & Practice
JA - J PUBLIC HEALTH MANAGE PRACT
VL - 14
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1078-4659
AD - US Department of Health and Human Services, Office of Public Health and Science, Office of Assistant Secretary for Health and Office of Minority Health, Rockville, Maryland 20852, USA. Peggy.Honore@hhs.gov
U2 - PMID: 18843245.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105574045&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dyer, Carmel Bitondo
AU - Marcus, Marianne
AU - Burnett, Jason
T1 - Introduction: The Consortium for Research in Elder Self-Neglect.
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
Y1 - 2008/11/02/Nov2008 Supplement
VL - 56
M3 - Article
SP - S239
EP - S240
PB - Wiley-Blackwell
SN - 00028614
AB - This article presents information about the development of research goals in self-neglect by the elderly. It has been found that elder self-neglect is reported more often than elder mistreatment, physical abuse of older people, caregiver neglect, and financial exploitation. Results of studies by the Consortium for Research in Elder Self-Neglect in Texas (CREST) are described and discussions from a 2006 CREST conference are presented.
KW - SELF-neglect
KW - HEALTH behavior
KW - AGING
KW - GERIATRICS
KW - AGEISM
N1 - Accession Number: 35037081; Dyer, Carmel Bitondo Marcus, Marianne 1 Burnett, Jason 2; Affiliation: 1: Center for Substance Abuse Prevention, Education and Research, School of Nursing, University of Texas at Houston Health Science Center, Houston, Texas. 2: Department of Medicine, Baylor College of Medicine, Houston, Texas;; Source Info: Nov2008 Supplement, Vol. 56, pS239; Subject Term: SELF-neglect; Subject Term: HEALTH behavior; Subject Term: AGING; Subject Term: GERIATRICS; Subject Term: AGEISM; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1111/j.1532-5415.2008.01974.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35037081&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - SCHOOMAKER, ERIC B.
T1 - Introduction.
JO - Medicine & Science in Sports & Exercise
JF - Medicine & Science in Sports & Exercise
Y1 - 2008/11/02/Nov2008 Supplement
VL - 40
M3 - Editorial
SP - S607
EP - S607
SN - 01959131
AB - The article presents a commentary on the use of state-of-the-art science methods to be able produce a possible health protection for the people who serve the military. The author provides his views on the current medical efforts to comprehend and eliminate stress fracture. Wellness, bone health, and prevention of diseases are also mentioned by the author.
KW - MEDICINE
KW - SCIENCE
KW - HEALTH
KW - MILITARY medicine
KW - BONES -- Diseases
KW - PREVENTION
KW - PREVENTIVE medicine
KW - FRACTURES
N1 - Accession Number: 34956528; SCHOOMAKER, ERIC B. 1; Affiliation: 1: US. Army Medical Command Office of the Surgeon General Falls Church, VA; Source Info: Nov2008 Supplement, Vol. 40, pS607; Subject Term: MEDICINE; Subject Term: SCIENCE; Subject Term: HEALTH; Subject Term: MILITARY medicine; Subject Term: BONES -- Diseases; Subject Term: PREVENTION; Subject Term: PREVENTIVE medicine; Subject Term: FRACTURES; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1249/MSS.0b013e3181892b23
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34956528&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Paoletti, Claudia
AU - Flamm, Eric
AU - Yan, William
AU - Meek, Sue
AU - Renckens, Suzy
AU - Fellous, Marc
AU - Kuiper, Harry
T1 - GMO risk assessment around the world: Some examples
JO - Trends in Food Science & Technology
JF - Trends in Food Science & Technology
Y1 - 2008/11/02/Nov2008 Supplement 1
VL - 19
M3 - Article
SP - S66
EP - S74
SN - 09242244
AB - All over the world, authorities responsible for the assessment and surveillance of foods and feeds derived using gene technology and the environmental impacts of genetically modified organisms (GMO) have chosen specific strategies to assess their safety. Although different regulatory frameworks are in place, almost all adopted risk assessment strategies are based on a common set of principles and guidelines. Here we provide some examples of these strategies and we compare them to highlight areas where an international consensus exists. Our hope is that even if limited, this short review can represent a first step towards the recognition of an international consensus and a broader dialog on GMOs regulation worldwide. [Copyright &y& Elsevier]
AB - Copyright of Trends in Food Science & Technology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FEEDS
KW - ANIMAL feeding
KW - SAFETY
KW - SPECIFICATIONS
N1 - Accession Number: 35121250; Paoletti, Claudia 1; Email Address: claudia.paoletti@efsa.europa.eu Flamm, Eric 2 Yan, William 3 Meek, Sue 4 Renckens, Suzy 1 Fellous, Marc 5 Kuiper, Harry 6; Affiliation: 1: European Food Safety Authority – EFSA, Largo N. Palli, 5/A, 43100 Parma, Italy 2: Food and Drug Administration, Office of Policy, HF-23, 5600 Fishers Lane, Rockville, MD 20857, USA 3: Food Directorate, Health Product and Food Branch, Health Canada, 251 Sir Fredrick Banting Driveway A.L. 2204E Ottawa, Canada ON K1A 0K9 4: Office of the Gene Technology Regulator, MDP 54, GPO Box 9848, Canberra, ACT 2601, Australia 5: Human Genetics Cochin Institute, ICGM, Team 21, 24 rue du Faubourg St-Jacques, 75014 Paris, France 6: RIKILT Institute of Food Safety Wageningen UR, P.O. Box 230, 6700 AE Wageningen, the Netherlands; Source Info: Nov2008 Supplement 1, Vol. 19, pS66; Subject Term: FEEDS; Subject Term: ANIMAL feeding; Subject Term: SAFETY; Subject Term: SPECIFICATIONS; NAICS/Industry Codes: 444220 Nursery, Garden Center, and Farm Supply Stores; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.tifs.2008.07.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35121250&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105635015
T1 - Healthy Start: lessons learned on interconception care.
AU - Badura M
AU - Johnson K
AU - Hench K
AU - Reyes M
Y1 - 2008/11/02/Nov2008 Supplement
N1 - Accession Number: 105635015. Language: English. Entry Date: 20090327. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Nov2008 Supplement. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Women's Health. NLM UID: 9101000.
KW - Health Promotion
KW - Perinatal Care
KW - Prepregnancy Care
KW - Risk Management
KW - Women's Health Services
KW - Female
KW - Pregnancy
KW - United States
SP - S61
EP - 6
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 18
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - Division of Healthy Start & Perinatal Services, Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Parklawn Building, 5600 Fishers Lane, Room 18-05, Rockville, MD 20857; mbadura@hrsa.gov
U2 - PMID: 19059550.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105635015&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Van Wagoner, Ryan M.
AU - Deeds, Jonathan R.
AU - Satake, Masayuki
AU - Ribeiro, Anthony A.
AU - Place, Allen R.
AU - Wright, Jeffrey L.C.
T1 - Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum
JO - Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
JF - Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Y1 - 2008/11/03/
VL - 49
IS - 45
M3 - Article
SP - 6457
EP - 6461
SN - 00404039
AB - Abstract: The karlotoxins (KmTxs) are a family of compounds produced by the dinoflagellate Karlodinium veneficum which cause membrane permeabilization. The structure of KmTx 1, determined using extensive 2D NMR spectroscopy, is very similar to that of the amphidinols and related compounds, though KmTx 1 features unique structural modifications of the conserved core region. The structure of KmTx 1 differs from that reported for KmTx 2, the only other reported karlotoxin to date, in lacking chlorination at its terminal alkene and possessing a hydrophobic arm that is two carbons longer. [Copyright &y& Elsevier]
AB - Copyright of Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance spectroscopy
KW - NUCLEAR spectroscopy
KW - SPECTRUM analysis
KW - QUALITATIVE chemical analysis
KW - Amphidinol
KW - Dinoflagellate
KW - Hemolytic toxin
KW - Karlotoxin
N1 - Accession Number: 34532204; Van Wagoner, Ryan M. 1 Deeds, Jonathan R. 2 Satake, Masayuki 1 Ribeiro, Anthony A. 3 Place, Allen R. 4 Wright, Jeffrey L.C. 1; Email Address: wrightj@uncw.edu; Affiliation: 1: Center for Marine Science, University of North Carolina at Wilmington, 5600 Marvin K Moss Lane, Wilmington, NC 28409, USA 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA 3: Duke NMR Center and Departments of Radiology and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA 4: Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Suite 236, Baltimore, MD 21202, USA; Source Info: Nov2008, Vol. 49 Issue 45, p6457; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: NUCLEAR spectroscopy; Subject Term: SPECTRUM analysis; Subject Term: QUALITATIVE chemical analysis; Author-Supplied Keyword: Amphidinol; Author-Supplied Keyword: Dinoflagellate; Author-Supplied Keyword: Hemolytic toxin; Author-Supplied Keyword: Karlotoxin; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.tetlet.2008.08.103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34532204&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karbiwnyk, Christine M.
AU - Faul, Kent C.
AU - Turnipseed, Sherri B.
AU - Andersen, Wendy C.
AU - Miller, Keith E.
T1 - Determination of oxytocin in a dilute IV solution by LC–MS n
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/11/04/
VL - 48
IS - 3
M3 - Article
SP - 672
EP - 677
SN - 07317085
AB - Abstract: The most common drug prescribed to induce labor in the United States is oxytocin, a peptide hormone composed of nine amino acids. Oxytocin is often reconstituted in intravenous (IV) saline solutions at less than 0.05unitsml−1 (125ngml−1) to be delivered at 1–4 drops per minute. Existing LC–UV methods for oxytocin do not have sufficient detection limits to quantitate and/or confirm oxytocin in IV solutions without sample concentration. A determinative and confirmatory method for oxytocin was developed using an LC–MS n ion trap instrument with an electrospray ionization (ESI) interface in positive ion mode. Separation was achieved on a C-18 column using an isocratic elution of water with 50% acetonitrile (v/v) and water with 0.05% formic acid (v/v) at a flow rate of 250μlmin−1. Data was acquired from the selected ion monitoring (SIM) of the precursor ion (m/z 1007.3) and MS2 scans from the collision induced dissociation of m/z 1007.3 at 30% collision energy. In this method, MS2 full scans were utilized to obtain three structurally significant ions for the unambiguous identification of oxytocin. Calibration standards, prepared in de-ionized water from 0.006 to 0.046unitsml−1, were linear with an R 2 value of 0.9983. The methods LOD and LOQ were 0.00084 and 0.0029unitsml−1 (2 and 7ngml−1), respectively. This LC–MS n method was used to determine the amount of oxytocin in a 0.04unitsml−1 clinical sample that was prepared in 0.9% sodium chloride IV solution. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXYTOCIN
KW - DRUGS -- Analysis
KW - ORGANIC synthesis (Chemistry)
KW - AMINO acids
KW - Ion-trap mass spectrometry
KW - IV solution
KW - Liquid chromatography
KW - Oxytocin
N1 - Accession Number: 34649213; Karbiwnyk, Christine M. 1; Email Address: christine.karbiwnyk@fda.hhs.gov Faul, Kent C. 2 Turnipseed, Sherri B. 1 Andersen, Wendy C. 1 Miller, Keith E. 3; Affiliation: 1: Animal Drugs Research Center, Food and Drug Administration, Denver, CO 80225-0087, United States 2: Denver District Laboratory, Food and Drug Administration, Denver, CO, United States 3: University of Denver, Denver, CO, United States; Source Info: Nov2008, Vol. 48 Issue 3, p672; Subject Term: OXYTOCIN; Subject Term: DRUGS -- Analysis; Subject Term: ORGANIC synthesis (Chemistry); Subject Term: AMINO acids; Author-Supplied Keyword: Ion-trap mass spectrometry; Author-Supplied Keyword: IV solution; Author-Supplied Keyword: Liquid chromatography; Author-Supplied Keyword: Oxytocin; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2008.06.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34649213&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - BAKER, D. JAMES
AU - SCHAEFER, MARK
AU - KENNEL, CHARLES F.
AU - GIBBONS, JOHN H.
AU - GROAT, CHARLES G.
AU - KENNEDY, DONALD
AU - REJESKI, DAVID
T1 - Environmental Agencies: Lessons Learned.
JO - Science
JF - Science
Y1 - 2008/11/07/
VL - 322
IS - 5903
M3 - Letter
SP - 855
EP - 856
SN - 00368075
AB - A letter to the editor in response to a previous letter about the creation of a federal research agency is presented.
KW - LETTERS to the editor
KW - RESEARCH
KW - UNITED States
N1 - Accession Number: 35580607; BAKER, D. JAMES 1; Email Address: djamesbaker@comcast.net SCHAEFER, MARK 2; Email Address: markschaefer24@msn.com KENNEL, CHARLES F. 3; Email Address: ckennel@ucsd.edu GIBBONS, JOHN H. 4; Email Address: jackgibbons@hughes.net GROAT, CHARLES G. 5; Email Address: cgroat@mail.utexas.edu KENNEDY, DONALD 6; Email Address: kennedyd@stanford.edu REJESKI, DAVID; Email Address: david.rejeski@wilsoncenter.org; Affiliation: 1: Administrator, National Oceanic and Atmospheric Association 2: Deputy Assistant Secretary of the Interior, Acting Director of the U.E. Geological Survey 3: Associate Administrator, National Aeronautics and Space Administration, Director of Mission to Planet Earth 4: Director, White House Office of Science and Technology Policy, Science Adviser to the President 5: Director, U.S. Geological Survey 6: Commissioner, Food and Drug Administration; Source Info: 11/7/2008, Vol. 322 Issue 5903, p855; Subject Term: LETTERS to the editor; Subject Term: RESEARCH; Subject Term: UNITED States; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choi, Mina
AU - Cho, Wan-Seob
AU - Han, Beom Seok
AU - Cho, Minjung
AU - Kim, Seung Yeul
AU - Yi, Jung-Yeon
AU - Ahn, Byeongwoo
AU - Kim, Seung Hee
AU - Jeong, Jayoung
T1 - Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2008/11/10/
VL - 182
IS - 1-3
M3 - Article
SP - 97
EP - 101
SN - 03784274
AB - Abstract: In order to evaluate the degree of pulmonary fibrosis and to identify the fibrogenic mechanisms induced by ultrafine amorphous silica (UFAS), UFAS suspensions (∼50μl) were instilled intratracheally into A/J mice at doses of 0, 2, 10 and 50mg/kg (n =5 per group). Mice were sacrificed at 24h, 1, 4 and 14weeks after exposure. Gomori’s trichrome staining revealed that UFAS induced severe alveolar epithelial thickening and pulmonary fibrosis at 1week, though animals almost recovered at 4 and 14weeks. The mRNA and protein levels of cytokines (IL-4, IL-10, IL-13 and IFN-γ), matrix metalloproteinases (MMP-2, MMP-9 and MMP-10) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in lung tissues were significantly elevated at 24h and 1week post-treatment, though these levels decreased to near the control range at 4 and 14weeks except IFN-γ and MMP-2. These results demonstrate that UFAS can induce pulmonary fibrosis in the same way as crystalline silica. However, the degree of fibrosis observed was transient. This study shows that cytokines (IL-4, IL-10, IL-13 and IFN-γ), MMPs (MMP-2, MMP-9 and MMP-10) and TIMP-1 play important roles in the fibrosis induced by the intratracheal instillation of UFAS. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Silica
KW - Pulmonary fibrosis
KW - Mice as laboratory animals
KW - Cytokines
KW - Metalloproteinases
KW - Lung diseases
KW - MMPs
KW - TIMP-1
KW - Ultrafine amorphous silica
N1 - Accession Number: 35072327; Choi, Mina 1; Cho, Wan-Seob 1; Han, Beom Seok 1; Cho, Minjung 1; Kim, Seung Yeul 1; Yi, Jung-Yeon 1; Ahn, Byeongwoo 2; Kim, Seung Hee 1; Jeong, Jayoung 1; Email Address: jjy_kfda@kfda.go.kr; Affiliations: 1: Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea; 2: Department of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University, Chungbuk 361-763, Republic of Korea; Issue Info: Nov2008, Vol. 182 Issue 1-3, p97; Thesaurus Term: TOXICOLOGY; Subject Term: Silica; Subject Term: Pulmonary fibrosis; Subject Term: Mice as laboratory animals; Subject Term: Cytokines; Subject Term: Metalloproteinases; Subject Term: Lung diseases; Author-Supplied Keyword: MMPs; Author-Supplied Keyword: TIMP-1; Author-Supplied Keyword: Ultrafine amorphous silica; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.toxlet.2008.08.019
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DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Dong, Ren G.
AU - Wu, John Z.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
T1 - A discussion on comparing alternative vibration measures with frequency-weighted accelerations defined in ISO standards
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2008/11/11/
VL - 317
IS - 3-5
M3 - Editorial
SP - 1042
EP - 1050
SN - 0022460X
N1 - Accession Number: 33532473; Dong, Ren G.; Email Address: rkd6@cdc.gov Wu, John Z. 1 Welcome, Daniel E. 1 McDowell, Thomas W. 1; Affiliation: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Nov2008, Vol. 317 Issue 3-5, p1042; Number of Pages: 9p; Document Type: Editorial
L3 - 10.1016/j.jsv.2008.03.028
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chun, Stella
AU - Li, Changgui
AU - Van Domselaar, Gary
AU - Wang, Junzhi
AU - Farnsworth, Aaron
AU - Cui, Xiaoyu
AU - Rode, Harold
AU - Cyr, Terry D.
AU - He, Runtao
AU - Li, Xuguang
T1 - Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins
JO - Vaccine
JF - Vaccine
Y1 - 2008/11/11/
VL - 26
IS - 48
M3 - Article
SP - 6068
EP - 6076
SN - 0264410X
AB - Abstract: The fusion peptide is the only universally conserved sequence in the hemagglutinins of all 16 subtypes of influenza A and two genetic lineages of influenza B viruses. Here, peptides selected by bioinformatics approach were modified and conjugated to overcome serious technical hurdles such as the high hydrophobicity and weak immunogenicity of the viral fusion peptides. Antibodies generated against fusion peptides demonstrated remarkable specificity against the viral sequences and robustness of quantitatively analyzing the viral hemagglutinins even under stringent conditions. As quantitatively revealed by antibody-binding experiments, the fusion peptides of diverse hemagglutinins are exposed to the same degree upon unfolding at neutral pH to the physiologically fusogenic state. To our knowledge, this is the first report on the quantitative determination of virtually all influenza vaccines using a single universal antibody. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hemagglutinin
KW - VACCINATION
KW - Immunoglobulins
KW - Influenza A virus
KW - Immunogenetics
KW - Influenza
KW - Denaturation of proteins
KW - Peptides
KW - Fusion peptide
KW - Influenza vaccine
KW - Potency testing
KW - Protein unfolding
KW - Universal antibodies
N1 - Accession Number: 35074309; Chun, Stella 1,2; Li, Changgui 3; Van Domselaar, Gary 4; Wang, Junzhi 3; Farnsworth, Aaron 1; Cui, Xiaoyu 3; Rode, Harold 5; Cyr, Terry D. 1; He, Runtao 4; Li, Xuguang 1,2; Email Address: Sean_Li@hc-sc.gc.ca; Affiliations: 1: Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; 2: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; 3: National Institute for the Control of Pharmaceutical and Biological Products, The State Food and Drug Administration, Beijing, PR China; 4: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; 5: Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; Issue Info: Nov2008, Vol. 26 Issue 48, p6068; Thesaurus Term: Hemagglutinin; Thesaurus Term: VACCINATION; Subject Term: Immunoglobulins; Subject Term: Influenza A virus; Subject Term: Immunogenetics; Subject Term: Influenza; Subject Term: Denaturation of proteins; Subject Term: Peptides; Author-Supplied Keyword: Fusion peptide; Author-Supplied Keyword: Influenza vaccine; Author-Supplied Keyword: Potency testing; Author-Supplied Keyword: Protein unfolding; Author-Supplied Keyword: Universal antibodies; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.09.015
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lindsey, Nicole P.
AU - Schroeder, Betsy A.
AU - Miller, Elaine R.
AU - Braun, M. Miles
AU - Hinckley, Alison F.
AU - Marano, Nina
AU - Slade, Barbara A.
AU - Barnett, Elizabeth D.
AU - Brunette, Gary W.
AU - Horan, Katherine
AU - Staples, J. Erin
AU - Kozarsky, Phyllis E.
AU - Hayes, Edward B.
T1 - Adverse event reports following yellow fever vaccination
JO - Vaccine
JF - Vaccine
Y1 - 2008/11/11/
VL - 26
IS - 48
M3 - Article
SP - 6077
EP - 6082
SN - 0264410X
AB - Abstract: Yellow fever (YF) vaccine has been used for prevention of YF since 1937 with over 500 million doses administered. However, rare reports of severe adverse events following vaccination have raised concerns about the vaccine’s safety. We reviewed reports of adverse events following YF vaccination reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) from 2000 to 2006. We used estimates of age and sex distribution of administered doses obtained from a 2006 survey of authorized vaccine providers to calculate age- and sex-specific reporting rates of all serious adverse events (SAE), anaphylaxis, YF vaccine-associated neurotropic disease, and YF vaccine-associated viscerotropic disease. Reporting rates of SAEs were substantially higher in males and in persons aged ≥60 years. These findings reinforce the generally acceptable safety profile of YF vaccine, but highlight the importance of physician and traveler education regarding the risks and benefits of YF vaccination, particularly for travelers ≥60 years of age. Vaccination should be limited to persons traveling to areas where the risk of YF is expected to exceed the risk of serious adverse events after vaccination, or if not medically contraindicated, where national regulations require proof of vaccination to prevent introduction of YF. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Yellow fever
KW - Adverse health care events
KW - Yellow fever vaccine
KW - Health surveys -- United States
KW - Sex distribution (Demography)
KW - United States
KW - Adverse event
KW - Vaccine
KW - VAERS
KW - Yellow fever
N1 - Accession Number: 35074310; Lindsey, Nicole P. 1; Email Address: nplindsey@cdc.gov; Schroeder, Betsy A. 2; Miller, Elaine R. 3; Braun, M. Miles 4; Hinckley, Alison F. 1; Marano, Nina 2; Slade, Barbara A. 3; Barnett, Elizabeth D. 5; Brunette, Gary W. 2; Horan, Katherine 2; Staples, J. Erin 1; Kozarsky, Phyllis E. 2,6; Hayes, Edward B. 1; Affiliations: 1: Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States; 2: Division of Global Migration and Quarantine, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; 3: Immunization Safety Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention, Atlanta, GA, United States; 4: Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, United States; 5: Clinical Immunization Safety Assessment Center, Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, MA, United States; 6: Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, United States; Issue Info: Nov2008, Vol. 26 Issue 48, p6077; Thesaurus Term: VACCINATION; Subject Term: Yellow fever; Subject Term: Adverse health care events; Subject Term: Yellow fever vaccine; Subject Term: Health surveys -- United States; Subject Term: Sex distribution (Demography); Subject: United States; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Vaccine; Author-Supplied Keyword: VAERS; Author-Supplied Keyword: Yellow fever; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.09.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35074310&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Derrick, Steven C.
AU - Perera, L.P.
AU - Dheenadhayalan, Veerabadran
AU - Yang, Amy
AU - Kolibab, Kristopher
AU - Morris, Sheldon L.
T1 - The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis
JO - Vaccine
JF - Vaccine
Y1 - 2008/11/11/
VL - 26
IS - 48
M3 - Article
SP - 6092
EP - 6098
SN - 0264410X
AB - Abstract: New post-exposure tuberculosis vaccination strategies are being developed to prevent disease in individuals latently infected with Mycobacterium tuberculosis. However, concerns about the potential induction of deleterious Koch-like reactions after immunization of persons with latent tuberculosis has limited progress in assessing the effectiveness of post-exposure vaccination. To evaluate the safety of immunization after M. tuberculosis infection, two mouse models were established, a drug treatment low bacterial burden model and an active disease model. Twelve different M. tuberculosis antigen preparations and vaccines (including DNA, subunit, viral vectored, and live, attenuated vaccines) were evaluated using these mouse models. In the low bacterial burden model, post-exposure vaccination did not induce significant reactivational disease and only injection of BCG evoked increases in lung inflammatory responses at 1 month after the immunizations. Additionally, although significant increases in lung inflammation were seen for animals injected with the hps65 DNA vaccine or a M. tuberculosis culture supernatant preparation, no differences in the survival periods were detected between vaccinated and non-vaccinated mice at 10 months post-immunization using the low bacterial burden model. For the active disease model, significantly more lung inflammation was observed at 1 month after administration of the hsp65 DNA vaccine but none of the antigen preparations tested increased the lung bacterial burdens at this early time point. Furthermore, vaccination of diseased mice with BCG or TB DNA vaccines did not significantly affect mortality rates compared to non-vaccinated controls at 10 months post-immunization. Overall, these data suggest that while the potential risk of inducing Koch-like reactions is low after immunization of persons with latent tuberculosis, extreme caution is still needed as post-exposure vaccines progress from pre-clinical experiments into the initial phases of clinical testing. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - DISEASES
KW - Communicable diseases -- Prevention
KW - Mycobacterium tuberculosis
KW - Mice
KW - Mice as laboratory animals
KW - DNA vaccines
KW - Animal disease models
KW - Safety
KW - Tuberculosis
KW - Vaccine
N1 - Accession Number: 35074312; Derrick, Steven C. 1; Email Address: steven.derrick@fda.hhs.gov; Perera, L.P. 2; Dheenadhayalan, Veerabadran 3; Yang, Amy 1; Kolibab, Kristopher 1; Morris, Sheldon L. 1; Affiliations: 1: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, United States; 2: Bldg. 10, Rm. 4B40, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1374, United States; 3: Aeras Global TB Vaccine Foundation, Rockville, MD 20850, United States; Issue Info: Nov2008, Vol. 26 Issue 48, p6092; Thesaurus Term: VACCINATION; Thesaurus Term: DISEASES; Thesaurus Term: Communicable diseases -- Prevention; Subject Term: Mycobacterium tuberculosis; Subject Term: Mice; Subject Term: Mice as laboratory animals; Subject Term: DNA vaccines; Subject Term: Animal disease models; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.09.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35074312&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mahajan, Babita
AU - Selvapandiyan, Angamuthu
AU - Gerald, Noel J.
AU - Majam, Victoria
AU - Hong Zheng
AU - Wickramarachchi, Thilan
AU - Tiwari, Jawahar
AU - Fujioka, Hisashi
AU - Moch, J. Kathleen
AU - Kumar, Nirbhay
AU - Aravind, L.
AU - Nakhasi, Hira L.
AU - Kumar, Sanjai
T1 - Centrins, Cell Cycle Regulation Proteins in Human Malaria Parasite Plasmodium falciparum.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2008/11/14/
VL - 283
IS - 46
M3 - Article
SP - 31871
EP - 31883
SN - 00219258
AB - Molecules and cellular mechanisms that regulate the process of cell division in malaria parasites remain poorly understood. In this study we isolate and characterize the four Plasmodium falciparum centrins (PfCENs) and, by growth complementation studies, provide evidence for their involvement in cell division. Centrins are cytoskeleton proteins with key roles in cell division, including centrosome duplication, and possess four Ca2+-binding EF hand domains. By means of phylogenetic analysis, we were able to decipher the evolutionary history of centrins in eukaryotes with particular emphasis on the situation in apicomplexans and other alveolates. Plasmodium possesses orthologs of four distinct centrin paralogs traceable to the ancestral alveolate, including two that are unique to alveolates. By real time PCR and/or immunofluorescence, we determined the expression of PfCEN mRNA or protein in sporozoites, asexual blood forms, gametocytes, and in the oocysts developing inside mosquito mid-gut. Immunoelectron microscopy studies showed that centrin is expressed in close proximity with the nucleus of sporozoites and asexual schizonts. Furthermore, confocal and widefield microscopy using the double staining with α-tubulin and centrin antibodies strongly suggested that centrin is associated with the parasite centrosome. Following the episomal expression of the four PfCENs in a centrin knock-out Leishmania donovani parasite line that exhibited a severe growth defect, one of the PfCENs was able to partially restore Leishmania growth rate and overcome the defect in cytokinesis in such mutant cell line. To our knowledge, this study is the first characterization of a Plasmodium molecule that is involved in the process of cell division. These results provide the opportunity to further explore the role of centrins in cell division in malaria parasites and suggest novel targets to construct genetically modified, live attenuated malaria vaccines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL cycle
KW - CELL proliferation
KW - CELL division (Biology)
KW - MEMBRANE proteins
KW - CENTROSOMES
KW - PLASMODIUM falciparum
KW - MOLECULAR biology
N1 - Accession Number: 35488314; Mahajan, Babita 1 Selvapandiyan, Angamuthu 1 Gerald, Noel J. 1 Majam, Victoria 1 Hong Zheng 1 Wickramarachchi, Thilan 1 Tiwari, Jawahar 2 Fujioka, Hisashi 3 Moch, J. Kathleen 4 Kumar, Nirbhay 5 Aravind, L. 6 Nakhasi, Hira L. 1 Kumar, Sanjai 1; Email Address: sanjai.kumar@fda.hhs.gov; Affiliation: 1: Divisions of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852 2: Division of Biostatistics, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852 3: Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4: Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 5: Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Baltimore, Maryland 21205 6: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20892; Source Info: 11/14/2008, Vol. 283 Issue 46, p31871; Subject Term: CELL cycle; Subject Term: CELL proliferation; Subject Term: CELL division (Biology); Subject Term: MEMBRANE proteins; Subject Term: CENTROSOMES; Subject Term: PLASMODIUM falciparum; Subject Term: MOLECULAR biology; Number of Pages: 13p; Illustrations: 6 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1074/jbc.M800028200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105582294
T1 - Screening for elevated blood lead levels in children and pregnant women.
AU - Mabry IR
Y1 - 2008/11/15/
N1 - Accession Number: 105582294. Language: English. Entry Date: 20090116. Revision Date: 20150711. Publication Type: Journal Article; case study; exam questions. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Lead -- Blood
KW - Education, Continuing (Credit)
KW - Female
KW - Lead Poisoning -- Prevention and Control
KW - Physicians, Family
KW - Pregnancy
SP - 1201
EP - 1202
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 78
IS - 10
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19035069.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jiang, W.
AU - Wang, W.D.
AU - Shi, X.H.
AU - Chen, H.Z.
AU - Zou, W.
AU - Guo, Z.
AU - Luo, J.M.
AU - Gu, Z.W.
AU - Zhang, X.D.
T1 - The effects of hydroxyapatite coatings on stress distribution near the dental implant–bone interface
JO - Applied Surface Science
JF - Applied Surface Science
Y1 - 2008/11/15/
VL - 255
IS - 2
M3 - Article
SP - 273
EP - 275
SN - 01694332
AB - Abstract: The effects of different thickness of hydroxyapatite (HA) coatings on bone stress distribution near the dental implant–bone interface are very important factors for the HA-coated dental implant design and clinical application. By means of finite element analysis (FEA), the bone stress distributions near the dental implant coated with different thicknesses from 0 to 200μm were calculated and analyzed under the 200N chewing load. In all cases, the maximal von Mises stresses in the bone are at the positions near the neck of dental implant on the lingual side, and decrease with the increase of the HA coatings thickness. The HA coatings weaken the stress concentration and improve the biomechanical property in the bone, however, in HA coatings thickness range of 60–120μm, the distinctions of that benefit are not obvious. In addition, considering the technical reason of HA coatings, we conclude that thickness of HA coatings range from 60 to 120μm would be the better choice for clinical application. [Copyright &y& Elsevier]
AB - Copyright of Applied Surface Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROXYAPATITE coating
KW - DENTAL implants
KW - STRESS concentration
KW - INTERFACES (Physical sciences)
KW - BIOMECHANICS
KW - 46.70.Lk
KW - Dental implant
KW - Finite element analysis
KW - Hydroxyapatite coatings
KW - Stress distribution
N1 - Accession Number: 34978315; Jiang, W. 1 Wang, W.D. 2 Shi, X.H. 1 Chen, H.Z. 1 Zou, W. 2 Guo, Z. 2 Luo, J.M. 1; Email Address: jmluo2006@126.com Gu, Z.W. 1 Zhang, X.D. 1; Affiliation: 1: Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, China 2: Center for Certification of Drug, State Food and Drug Administration, Beijing 100061, China; Source Info: Nov2008, Vol. 255 Issue 2, p273; Subject Term: HYDROXYAPATITE coating; Subject Term: DENTAL implants; Subject Term: STRESS concentration; Subject Term: INTERFACES (Physical sciences); Subject Term: BIOMECHANICS; Author-Supplied Keyword: 46.70.Lk; Author-Supplied Keyword: Dental implant; Author-Supplied Keyword: Finite element analysis; Author-Supplied Keyword: Hydroxyapatite coatings; Author-Supplied Keyword: Stress distribution; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.apsusc.2008.06.165
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34978315&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shi, X.H.
AU - Jiang, W.
AU - Chen, H.Z.
AU - Zou, W.
AU - Wang, W.D.
AU - Guo, Z.
AU - Luo, J.M.
AU - Gu, Z.W.
AU - Zhang, X.D.
T1 - The study of mechanical behavior on the interface between calcar-defect femur and restorations by means of finite element analysis
JO - Applied Surface Science
JF - Applied Surface Science
Y1 - 2008/11/15/
VL - 255
IS - 2
M3 - Article
SP - 290
EP - 292
SN - 01694332
AB - Abstract: The mechanical behaviors of calcar-defected femur and restorations under physiological load are the key factors that will greatly influence the success of femur calcar defect repairing, especially the stress distribution on the bone-restoration interface. 3D finite elements analysis (FEA) was used to analyze the mechanical characters on the interfaces between femoral calcar defects and bone cement or HA restorations. Under the load of two times of a human weight (1436.03N) and with the increase of the defect dimension from 6mm to 12mm, the maximal stresses on the surface of restorations are from 7.06MPa to 11.89MPa for bone cement and 2.97–9MPa for HA separately. In this condition, HA restoration will probably be broken on the bone-restoration interface when the defect diameter is beyond 8mm. Furthermore, under the load of 1.5 times of a human weight, HA restoration would not be safe unless the defect dimension is smaller than 10mm, because the maximal stress (4.62MPa) on the restoration is only a little lower than compressive strength of HA, otherwise the bone fixation device should be applied to ensure the safety. It is relatively safe for all restorations under all the tested defect sizes when the load is just the weight of a human body. [Copyright &y& Elsevier]
AB - Copyright of Applied Surface Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATERIALS -- Mechanical properties
KW - INTERFACES (Physical sciences)
KW - FINITE element method
KW - FEMUR
KW - BONE cements
KW - STRESS concentration
KW - 46.70.Lk
KW - Bone defect
KW - Bone-restoration interface
KW - Defect restoration
KW - FEA
KW - Stress distribution
N1 - Accession Number: 34978320; Shi, X.H. 1 Jiang, W. 1 Chen, H.Z. 1 Zou, W. 1 Wang, W.D. 2 Guo, Z. 2 Luo, J.M. 1; Email Address: jmluo2006@126.com Gu, Z.W. 1 Zhang, X.D. 1; Affiliation: 1: Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, China 2: Center for Certification of Drug, State Food and Drug Administration, Beijing 100061, China; Source Info: Nov2008, Vol. 255 Issue 2, p290; Subject Term: MATERIALS -- Mechanical properties; Subject Term: INTERFACES (Physical sciences); Subject Term: FINITE element method; Subject Term: FEMUR; Subject Term: BONE cements; Subject Term: STRESS concentration; Author-Supplied Keyword: 46.70.Lk; Author-Supplied Keyword: Bone defect; Author-Supplied Keyword: Bone-restoration interface; Author-Supplied Keyword: Defect restoration; Author-Supplied Keyword: FEA; Author-Supplied Keyword: Stress distribution; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.apsusc.2008.06.164
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34978320&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Sheth, Anandi N.
AU - Wiersma, Petra
AU - Atrubin, David
AU - Dubey, Vinita
AU - Zink, Donald
AU - Skinner, Guy
AU - Doerr, Fran
AU - Juliao, Patricia
AU - Gonzalez, German
AU - Burnett, Cindy
AU - Drenzek, Cherie
AU - Shuler, Carrie
AU - Austin, John
AU - Ellis, Andrea
AU - Maslanka, Susan
AU - Sobel, Jeremy
T1 - International Outbreak of Severe Botulism with Prolonged Toxemia Caused by Commercial Carrot Juice.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/11/15/
VL - 47
IS - 10
M3 - Abstract
SP - 1245
EP - 1251
SN - 10584838
AB - Background. On 8 September 2006, 3 Georgia residents presented with symptoms of food-borne botulism, a potentially fatal illness caused by Clostridium botulinum neurotoxins. Methods. Investigators reviewed medical records and interviewed patients and family members. Foods from patients' homes and samples of the implicated commercial beverage were tested for botulinum toxin and C. botulinum by standard methods. Results. The patients presented with cranial neuropathies and flaccid paralysis; all patients required mechanical ventilation. The 3 Georgia patients had consumed carrot juice from the same bottle before illness onset. An additional case in Florida and 2 in Ontario, Canada, were subsequently identified in patients who had consumed carrot juice. Serum samples obtained from 5 patients tested positive for botulinum toxin type A—in one patient, 12 days after illness onset, and in another patient, 25 days after illness onset. Carrot juice produced by 1 manufacturer, recovered from patients' homes in Georgia, Florida, and Ontario, yielded type A toxin. The juice contained no added sugar, salt, or preservative; inappropriate refrigeration likely resulted in botulinum toxin production. Conclusion. This outbreak was caused by commercially produced, internationally distributed carrot juice that was contaminated with botulinum toxin. When toxemia persists, treatment for botulism should be considered even if diagnosed weeks after illness onset. The implicated pasteurized carrot juice had no barriers to growth of C. botulinum other than refrigeration; additional protective measures for carrot juice are needed to prevent future outbreaks. The US Food and Drug Administration has since issued industry guidance to reduce the risk of C. botulinum intoxication from low-acid refrigerated juices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Botulism
KW - Foodborne diseases
KW - Artificial respiration
KW - Clostridium botulinum
KW - Botulinum toxin
KW - Neuropathy
KW - Vegetable juices
KW - Georgia
KW - Florida
KW - Ontario
KW - United States. Food & Drug Administration
N1 - Accession Number: 34948600; Sheth, Anandi N. 1,2; Email Address: asheth@cdc.gov; Wiersma, Petra 2,3; Atrubin, David 4; Dubey, Vinita 5; Zink, Donald 6; Skinner, Guy 7; Doerr, Fran 8; Juliao, Patricia 1,2; Gonzalez, German 3; Burnett, Cindy 3; Drenzek, Cherie 3; Shuler, Carrie 3; Austin, John 9; Ellis, Andrea 10; Maslanka, Susan 11; Sobel, Jeremy 1; Affiliations: 1: Enteric Diseases Epidemiology Branch; 2: Epidemic Intelligence Service, Centers for Disease Control and Prevention; 3: Georgia Division of Public Health, Atlanta, Georgia; 4: Hillsborough County Health Department, Tampa, Florida; 5: Toronto Public Health, Toronto; 6: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland; 7: National Center for Food Safety and Technology, US Food and Drug Administration, Summit Argo; 8: Illinois Institute of Technology, Chicago, Illinois; 9: Health Canada, Ottawa; 10: Public Health Agency of Canada, Guelph, Ontario, Canada; 11: Outbreak Investigations Unit, Enteric Diseases Laboratory Branch; Issue Info: 11/15/2008, Vol. 47 Issue 10, p1245; Thesaurus Term: Botulism; Thesaurus Term: Foodborne diseases; Thesaurus Term: Artificial respiration; Subject Term: Clostridium botulinum; Subject Term: Botulinum toxin; Subject Term: Neuropathy; Subject Term: Vegetable juices; Subject: Georgia; Subject: Florida; Subject: Ontario ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 311421 Fruit and Vegetable Canning; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; Number of Pages: 7p; Illustrations: 3 Charts; Document Type: Abstract
L3 - 10.1086/592574
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=34948600&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stefaniak, Aleksandr B.
AU - Chipera, Steve J.
AU - Day, Gregory A.
AU - Sabey, Phil
AU - Dickerson, Robert M.
AU - Sbarra, Deborah C.
AU - Duling, Mathew G.
AU - Lawrence, Robert B.
AU - Stanton, Marcia L.
AU - Scripsick, Ronald C.
T1 - Physicochemical Characteristics of Aerosol Particles Generated During the Milling of Beryllium Silicate Ores: Implications for Risk Assessment.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/11/15/
VL - 71
IS - 22
M3 - Article
SP - 1468
EP - 1481
SN - 15287394
AB - Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 μg/m3 (beryl ore grinding) to 2.1 μg/m3 (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were < 20% in low-energy input operation areas (ore crushing, hydroxide product drumming) and > 80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHEMICALS -- Physiological effect
KW - IMMUNOPATHOLOGY
KW - TRANSFER factor (Immunology)
KW - GEMS & precious stones
KW - BERYLLIUM
KW - AEROSOLS (Sprays)
N1 - Accession Number: 34612139; Stefaniak, Aleksandr B. 1; Email Address: AStefaniak@cdc.gov Chipera, Steve J. 2 Day, Gregory A. 1 Sabey, Phil 3 Dickerson, Robert M. 4 Sbarra, Deborah C. 1 Duling, Mathew G. 1 Lawrence, Robert B. 1 Stanton, Marcia L. 1 Scripsick, Ronald C. 5; Affiliation: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Earth and Environmental Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA 3: Brush Resources, Delta, Utah, USA 4: Structure Property Relations Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA 5: Industrial Hygiene and Safety, Institutional Policy, Los Alamos National Laboratory, Los Alamos, New Mexico, USA; Source Info: Nov2008, Vol. 71 Issue 22, p1468; Subject Term: CHEMICALS -- Physiological effect; Subject Term: IMMUNOPATHOLOGY; Subject Term: TRANSFER factor (Immunology); Subject Term: GEMS & precious stones; Subject Term: BERYLLIUM; Subject Term: AEROSOLS (Sprays); NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 414410 Jewellery and watch merchant wholesalers; NAICS/Industry Codes: 423940 Jewelry, Watch, Precious Stone, and Precious Metal Merchant Wholesalers; Number of Pages: 14p; Illustrations: 1 Black and White Photograph, 1 Diagram, 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15287390802349883
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34612139&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Arvidson, Kirk B.
T1 - FDA toxicity databases and real-time data entry
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/11/15/
VL - 233
IS - 1
M3 - Article
SP - 17
EP - 19
SN - 0041008X
AB - Abstract: Structure-searchable electronic databases are valuable new tools that are assisting the FDA in its mission to promptly and efficiently review incoming submissions for regulatory approval of new food additives and food contact substances. The Center for Food Safety and Applied Nutrition''s Office of Food Additive Safety (CFSAN/OFAS), in collaboration with Leadscope, Inc., is consolidating genetic toxicity data submitted in food additive petitions from the 1960s to the present day. The Center for Drug Evaluation and Research, Office of Pharmaceutical Science''s Informatics and Computational Safety Analysis Staff (CDER/OPS/ICSAS) is separately gathering similar information from their submissions. Presently, these data are distributed in various locations such as paper files, microfiche, and non-standardized toxicology memoranda. The organization of the data into a consistent, searchable format will reduce paperwork, expedite the toxicology review process, and provide valuable information to industry that is currently available only to the FDA. Furthermore, by combining chemical structures with genetic toxicity information, biologically active moieties can be identified and used to develop quantitative structure–activity relationship (QSAR) modeling and testing guidelines. Additionally, chemicals devoid of toxicity data can be compared to known structures, allowing for improved safety review through the identification and analysis of structural analogs. Four database frameworks have been created: bacterial mutagenesis, in vitro chromosome aberration, in vitro mammalian mutagenesis, and in vivo micronucleus. Controlled vocabularies for these databases have been established. The four separate genetic toxicity databases are compiled into a single, structurally-searchable database for easy accessibility of the toxicity information. Beyond the genetic toxicity databases described here, additional databases for subchronic, chronic, and teratogenicity studies have been prepared. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - FOOD additives -- Law & legislation
KW - REGULATORY approval
KW - TOXICOLOGY
KW - UNITED States
KW - Chronic
KW - Controlled vocabulary
KW - Food additives
KW - Food contact substances
KW - Food safety
KW - Genetic toxicity databases
KW - QSAR
KW - Quantitative structure–activity relationship modeling
KW - Safety assessment
KW - Safety review
KW - SAR
KW - Structure-searchable databases
KW - Subchronic
KW - teratogenicity
KW - UNITED States. Food & Drug Administration
KW - CENTER for Drug Evaluation & Research (U.S.)
KW - LEADSCOPE Inc.
N1 - Accession Number: 35290754; Arvidson, Kirk B. 1; Email Address: kirk.arvidson@fda.hhs.gov; Affiliation: 1: Division of Food Contact Notifications, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-275, College Park, MD, 20740, USA; Source Info: Nov2008, Vol. 233 Issue 1, p17; Subject Term: DATABASES; Subject Term: FOOD additives -- Law & legislation; Subject Term: REGULATORY approval; Subject Term: TOXICOLOGY; Subject Term: UNITED States; Author-Supplied Keyword: Chronic; Author-Supplied Keyword: Controlled vocabulary; Author-Supplied Keyword: Food additives; Author-Supplied Keyword: Food contact substances; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: Genetic toxicity databases; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Quantitative structure–activity relationship modeling; Author-Supplied Keyword: Safety assessment; Author-Supplied Keyword: Safety review; Author-Supplied Keyword: SAR; Author-Supplied Keyword: Structure-searchable databases; Author-Supplied Keyword: Subchronic; Author-Supplied Keyword: teratogenicity; Company/Entity: UNITED States. Food & Drug Administration DUNS Number: Company/Entity: CENTER for Drug Evaluation & Research (U.S.) DUNS Number: Company/Entity: LEADSCOPE Inc. DUNS Number: 026968540; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.taap.2007.12.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35290754&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sargent, Linda M.
AU - Ensell, Mang X.
AU - Ostvold, Anne-Carine
AU - Baldwin, Kimberly T.
AU - Kashon, Michael L.
AU - Lowry, David T.
AU - Senft, Jamie R.
AU - Jefferson, Amy M.
AU - Johnson, Robert C.
AU - Li, Zhi
AU - Tyson, Frederick L.
AU - Reynolds, Steven H.
T1 - Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/11/15/
VL - 233
IS - 1
M3 - Article
SP - 81
EP - 91
SN - 0041008X
AB - Abstract: The incidence of adenocarcinoma of the lung is increasing in the United States, however, the difficulties in obtaining lung cancer families and representative samples of early to late stages of the disease have lead to the study of mouse models for lung cancer. We used Spectral Karyotyping (SKY), mapping with fluorescently labeled genomic clones (FISH), comparative genomic hybridization (CGH) arrays, gene expression arrays, Western immunoblot and real time polymerase chain reaction (PCR) to analyze nine pairs of high-invasive and low-invasive tumor cell strains derived from early passage mouse lung adenocarcinoma cells to detect molecular changes associated with tumor invasion. The duplication of chromosomes 1 and 15 and deletion of chromosome 8 were significantly associated with a high-invasive phenotype. The duplication of chromosome 1 at band C4 and E1/2–H1 were the most significant chromosomal changes in the high-invasive cell strains. Mapping with FISH and CGH array further narrowed the minimum region of duplication of chromosome 1 to 71–82 centimorgans (cM). Expression array analysis and confirmation by real time PCR demonstrated increased expression of COX-2, Translin (TB-RBP), DYRK3, NUCKS and Tubulin-α4 genes in the high-invasive cell strains. Elevated expression and copy number of these genes, which are involved in inflammation, cell movement, proliferation, inhibition of apoptosis and telomere elongation, were associated with an invasive phenotype. Similar linkage groups are altered in invasive human lung adenocarcinoma, implying that the mouse is a valid genetic model for the study of the progression of human lung adenocarcinoma. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOCARCINOMA
KW - CANCER cells
KW - MICE as laboratory animals
KW - DISEASE incidence
KW - LUNGS -- Cancer
KW - ANIMAL disease models
KW - WESTERN immunoblotting
KW - GENE expression
KW - UNITED States
KW - Amplification
KW - CGH array
KW - Chromosome 1
KW - Lung adenocarcinoma
KW - Mouse model
N1 - Accession Number: 35290764; Sargent, Linda M. 1; Email Address: LSargent@cdc.gov Ensell, Mang X. 2 Ostvold, Anne-Carine 3 Baldwin, Kimberly T. 1 Kashon, Michael L. 1 Lowry, David T. 1 Senft, Jamie R. 1 Jefferson, Amy M. 1 Johnson, Robert C. 4 Li, Zhi 5 Tyson, Frederick L. 6 Reynolds, Steven H. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: St. Jude Children's Research Hospital, Memphis, TN 38105, USA 3: University of Oslo, Oslo, Norway 4: Spectral Genomics Inc., Houston, TX 77054, USA 5: John Hopkins University, Baltimore, MD 21205, USA 6: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Source Info: Nov2008, Vol. 233 Issue 1, p81; Subject Term: ADENOCARCINOMA; Subject Term: CANCER cells; Subject Term: MICE as laboratory animals; Subject Term: DISEASE incidence; Subject Term: LUNGS -- Cancer; Subject Term: ANIMAL disease models; Subject Term: WESTERN immunoblotting; Subject Term: GENE expression; Subject Term: UNITED States; Author-Supplied Keyword: Amplification; Author-Supplied Keyword: CGH array; Author-Supplied Keyword: Chromosome 1; Author-Supplied Keyword: Lung adenocarcinoma; Author-Supplied Keyword: Mouse model; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2008.01.031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35290764&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pohl, H.R.
AU - Abadin, H.G.
T1 - Chemical mixtures: Evaluation of risk for child-specific exposures in a multi-stressor environment
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2008/11/15/
VL - 233
IS - 1
M3 - Article
SP - 116
EP - 125
SN - 0041008X
AB - Abstract: Evaluating the health impact from exposure to chemical mixtures is multifaceted. One component is exposure. Exposure, and consequently risk assessment for mixtures and chemicals in general, are often viewed in terms of a given exposure to a given population at a given location over a given time period. However, environmental exposures are present throughout human lifetime. As a result, an evaluation of risk must include the distinctive characteristics related to chemical exposures which will impact risk depending upon the particular life stage where exposure occurs. Risks to offspring may be associated with unique exposures in utero, during infancy, childhood, or adolescent periods. For example, exposure of infants to anthropogenic chemicals via breast milk may be of concern. The Agency for Toxic Substances and Disease Registry''s (ATSDR''s) approach to evaluating risks associated with exposure to mixtures of chemicals is presented. In addition to the breast milk issues, indoor exposure to combined air pollutants, drinking water contaminants, and soil and dust contaminants are discussed. The difference between a mixture''s risk evaluation for children and adults is in the distinct exposure scenarios resulting from variations in behavior, physiology, and/or pharmacokinetics between adults and children rather than in the method for the specific mixtures evaluation per se. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - CHILDREN -- Health
KW - AIR pollution
KW - CONTAMINATION of drinking water
KW - PHARMACOKINETICS
KW - SOIL pollution
KW - UNITED States
KW - Chemical mixtures
KW - Children's health
KW - Life stages
KW - UNITED States. Agency for Toxic Substances & Disease Registry
N1 - Accession Number: 35290769; Pohl, H.R.; Email Address: hrp1@cdc.gov Abadin, H.G. 1; Affiliation: 1: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA; Source Info: Nov2008, Vol. 233 Issue 1, p116; Subject Term: HEALTH risk assessment; Subject Term: CHILDREN -- Health; Subject Term: AIR pollution; Subject Term: CONTAMINATION of drinking water; Subject Term: PHARMACOKINETICS; Subject Term: SOIL pollution; Subject Term: UNITED States; Author-Supplied Keyword: Chemical mixtures; Author-Supplied Keyword: Children's health; Author-Supplied Keyword: Life stages; Company/Entity: UNITED States. Agency for Toxic Substances & Disease Registry; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2008.01.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35290769&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jing, Yi
AU - Dowdy, Janet A.
AU - Van Scott, Michael R.
AU - Fedan, Jeffrey S.
T1 - Simultaneous measurement of mechanical responses and transepithelial potential difference and resistance, in guinea-pig isolated, perfused trachea using a novel apparatus: Pharmacological characterization
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2008/11/19/
VL - 598
IS - 1-3
M3 - Article
SP - 98
EP - 103
SN - 00142999
AB - Abstract: The isolated, perfused trachea preparation has been used to compare reactivity of the intact airway in response to differential exposure of the mucosal (intraluminal) and serosal (extraluminal) surfaces to contractile and relaxant agonists and other agents, and to gain insight into the modulatory role of the epithelium and the pathways involved. The apparatus has also been configured for simultaneous measurement of transepithelial potential difference and changes in tracheal diameter, thereby providing parallel observations of epithelial and smooth muscle function and reactivity to drugs. The transepithelial potential difference is a product of transepithelial resistance and short circuit current, and the present study describes a novel isolated, perfused tracheal apparatus which allows simultaneous measurement of transepithelial potential difference, transepithelial resistance and mechanical responses of the smooth muscle. The apparatus was validated using well-known ion transport inhibitors [intraluminal amiloride and 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB), extraluminal ouabain and bumetanide], bronchoactive agonists (extraluminal methacholine, histamine and terbutaline), and osmolytes (intraluminal d-mannitol and NaCl) to induce epithelium-derived relaxing factor-mediated relaxations. This apparatus will facilitate investigation of interactions between the epithelium and smooth muscle in airways that retain their in situ structure, and signaling mechanisms potentially involved in the regulation of airway smooth muscle tone. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY organs
KW - GUINEA pigs as laboratory animals
KW - TRACHEA
KW - DRUG antagonism
KW - EPITHELIUM
KW - SMOOTH muscle
KW - Airway smooth muscle
KW - Epithelium
KW - Guinea pig
KW - Perfused trachea
KW - Transepithelial potential difference
KW - Transepithelial resistance
N1 - Accession Number: 34896924; Jing, Yi 1 Dowdy, Janet A. 2 Van Scott, Michael R. 3 Fedan, Jeffrey S. 2; Email Address: jsf2@cdc.gov; Affiliation: 1: Department of Biochemistry and Molecular Pharmacology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA; Source Info: Nov2008, Vol. 598 Issue 1-3, p98; Subject Term: RESPIRATORY organs; Subject Term: GUINEA pigs as laboratory animals; Subject Term: TRACHEA; Subject Term: DRUG antagonism; Subject Term: EPITHELIUM; Subject Term: SMOOTH muscle; Author-Supplied Keyword: Airway smooth muscle; Author-Supplied Keyword: Epithelium; Author-Supplied Keyword: Guinea pig; Author-Supplied Keyword: Perfused trachea; Author-Supplied Keyword: Transepithelial potential difference; Author-Supplied Keyword: Transepithelial resistance; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ejphar.2008.09.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kohl, Katrin S.
AU - Magnus, Manya
AU - Ball, Robert
AU - Halsey, Neal
AU - Shadomy, Sean
AU - Farley, Thomas A.
T1 - Applicability, reliability, sensitivity, and specificity of six Brighton Collaboration standardized case definitions for adverse events following immunization
JO - Vaccine
JF - Vaccine
Y1 - 2008/11/25/
VL - 26
IS - 50
M3 - Article
SP - 6349
EP - 6360
SN - 0264410X
AB - Abstract: We evaluated the applicability, reliability, sensitivity, and specificity of six standardized case definitions for adverse events following immunization (AEFI) (for fever, generalized convulsive seizure, hypotonic–hyporesponsive episode, intussusception, nodule, and persistent crying) developed by the Brighton Collaboration using the U.S. Vaccine Adverse Event Reporting System (VAERS). The evaluation included: (a) the development of codified search strings using standardized coding terminology, and (b) for sensitivity and specificity analyses, the development of a “gold standard” for case determination by clinical expert reviews, and its comparison against the application of the definitions to VAERS reports by nonclinicians. Application of the case definitions in an automated approach proved to be valid, feasible, and unlikely to miss confirmed cases of the reported clinical event. The definitions had variable but generally high sensitivity and specificity compared to clinician review, which in itself yielded inconsistent case determination. The study demonstrated the need for the developed standardized definitions for AEFI and their usefulness in passive surveillance. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vaccination
KW - COMPLICATIONS
KW - Immunization -- Complications
KW - Convulsions
KW - Intestinal intussusception
KW - Nodular disease
KW - Fever
KW - Crying
KW - Medical personnel
KW - Coding theory
KW - Adverse events following immunization
KW - Case definitions
KW - Evaluation methodology
KW - Generalized convulsive seizure
KW - Hypotonic–hyporesponsive episode
KW - Intussusception
KW - Nodule at injection site
KW - Persistent crying
N1 - Accession Number: 35328988; Kohl, Katrin S. 1; Email Address: kfk0@cdc.gov; Magnus, Manya 2; Ball, Robert 3; Halsey, Neal 4,5; Shadomy, Sean 1; Farley, Thomas A. 6; Affiliations: 1: Immunization Safety Office, Office of the Chief Science Officer, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop E-03, Atlanta, GA, USA; 2: Department of Epidemiology and Biostatistics, George Washington University School of Public Health, Washington, DC, USA; 3: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; 4: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 5: Clinical Immunization Safety Assessment network, USA; 6: Department of Community Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA; Issue Info: Nov2008, Vol. 26 Issue 50, p6349; Thesaurus Term: Vaccination; Subject Term: COMPLICATIONS; Subject Term: Immunization -- Complications; Subject Term: Convulsions; Subject Term: Intestinal intussusception; Subject Term: Nodular disease; Subject Term: Fever; Subject Term: Crying; Subject Term: Medical personnel; Subject Term: Coding theory; Author-Supplied Keyword: Adverse events following immunization; Author-Supplied Keyword: Case definitions; Author-Supplied Keyword: Evaluation methodology; Author-Supplied Keyword: Generalized convulsive seizure; Author-Supplied Keyword: Hypotonic–hyporesponsive episode; Author-Supplied Keyword: Intussusception; Author-Supplied Keyword: Nodule at injection site; Author-Supplied Keyword: Persistent crying; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.09.002
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - David M. Asher
T1 - Kuru: memories of the NIH years.
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
Y1 - 2008/11/27/
VL - 363
IS - 1510
M3 - Article
SP - 3618
EP - 3625
SN - 09628436
N1 - Accession Number: 34719258; David M. Asher 1; Affiliation: 1: Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, CBER FDA HFM-313, 1401 Rockville Pike, Rockville, MD 20852-1448, USA; Source Info: Nov2008, Vol. 363 Issue 1510, p3618; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105701681
T1 - Chapter 3 lung disease in flavoring and food production: learning from butter flavoring.
AU - Sahakian N
AU - Kreiss K
Y1 - 2008/12//
N1 - Accession Number: 105701681. Language: English. Entry Date: 20081128. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. Special Interest: Nutrition. NLM UID: 9001271.
KW - Flavoring Agents -- Adverse Effects
KW - Food Handling
KW - Lung Diseases -- Chemically Induced
KW - Occupational Diseases
KW - Occupational Exposure
KW - Bronchiolitis Obliterans -- Chemically Induced
KW - Bronchiolitis Obliterans -- Diagnosis
KW - Bronchiolitis Obliterans -- Epidemiology
KW - Bronchiolitis Obliterans -- Prevention and Control
KW - Environmental Exposure -- Adverse Effects
KW - Lung Diseases -- Diagnosis
KW - Lung Diseases -- Epidemiology
KW - Lung Diseases -- Prevention and Control
KW - Occupational Diseases -- Diagnosis
KW - Occupational Diseases -- Epidemiology
KW - Occupational Diseases -- Prevention and Control
KW - Public Health
KW - Risk Factors
KW - Volatilization
SP - 163
EP - 192
JO - Advances in Food & Nutrition Research
JF - Advances in Food & Nutrition Research
JA - ADV FOOD NUTR RES
VL - 55
CY - Burlington, Massachusetts
PB - Academic Press Inc.
SN - 1043-4526
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia 26505.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hof, Irene
AU - Arbab-Zadeh, Armin
AU - Dong, Jun
AU - Scherr, Daniel
AU - Chilukuri, Karuna
AU - Calkins, Hugh
T1 - Validation of a Simplified Method to Determine Left Atrial Volume by Computed Tomography in Patients With Atrial Fibrillation
JO - American Journal of Cardiology
JF - American Journal of Cardiology
Y1 - 2008/12//
VL - 102
IS - 11
M3 - Article
SP - 1567
EP - 1570
SN - 00029149
AB - The success of catheter ablation of atrial fibrillation (AF) is highly dependent on a preprocedural assessment of the size and shape of the left atrium. The most precise method to determine left atrial (LA) volume using computed tomography requires manually tracing the LA area of each cross-sectional image. This is a labor-intensive and time-consuming technique. The purpose of this study was to compare LA volume derived using the “gold-standard” multiple-slice technique with LA volume estimated using 3 orthogonal LA dimensions in patients with AF. The patient population was composed of 100 patients referred for catheter ablation of AF (87 men, mean age 57 ± 12 years). AF was paroxysmal in 49 patients and persistent in 51. Each patient underwent computed tomography before catheter ablation, and LA volume was measured using the 2 methods. The mean LA volume measured using the multiple-slice technique was 136 ± 46 ml. According to the simpler estimation approach, the mean LA volume was 112 ± 41 ml. A close correlation was noted between atrial volumes determined using the 2 methods (r = 0.91, p <0.001). There was a mean underestimation of LA volume by the estimation technique of 17 ± 13%. In conclusion, the results of this study reveal that LA volume determined using an estimation approach correlates closely with true LA volume as determined using the gold-standard multiple-slice approach. This estimation approach underestimates true LA volume by approximately 20%. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Cardiology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIAC volume
KW - LEFT heart ventricle
KW - TOMOGRAPHY
KW - ATRIAL fibrillation
KW - PATIENTS
KW - CROSS-sectional method
KW - CATHETER ablation
N1 - Accession Number: 35392175; Hof, Irene 1 Arbab-Zadeh, Armin 2 Dong, Jun 2,3 Scherr, Daniel 2,4 Chilukuri, Karuna 2 Calkins, Hugh 2; Email Address: hcalkins@jhmi.edu; Affiliation: 1: Department of Cardiology, Division of Heart and Lungs, University Medical Center, Utrecht, The Netherlands 2: Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 3: Division of Cardiovascular Devices, Center for Devices and Radiological Health, United States Food and Drug Administration, Rockville, Maryland 4: Department of Medicine, Division of Cardiology, Medical University of Graz, Graz, Austria; Source Info: Dec2008, Vol. 102 Issue 11, p1567; Subject Term: CARDIAC volume; Subject Term: LEFT heart ventricle; Subject Term: TOMOGRAPHY; Subject Term: ATRIAL fibrillation; Subject Term: PATIENTS; Subject Term: CROSS-sectional method; Subject Term: CATHETER ablation; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.amjcard.2008.07.048
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Calvert, Geoffrey M.
AU - Karnik, Jennifer
AU - Mehler, Louise
AU - Beckman, John
AU - Morrissey, Barbara
AU - Sievert, Jennifer
AU - Barrett, Rosanna
AU - Lackovic, Michelle
AU - Mabee, Laura
AU - Schwartz, Abby
AU - Mitchell, Yvette
AU - Moraga-McHaley, Stephanie
T1 - Acute Pesticide Poisoning Among Agricultural Workers in the United States, 1998-2005.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/12//
VL - 51
IS - 12
M3 - Article
SP - 883
EP - 898
SN - 02713586
AB - The article presents a study which evaluates the poisoning of pesticides among agricultural workers in the U.S. in 1998-2005. The study identified cases of acute pesticide poisoning in agricultural workers between the ages of 15 and 64 years and calculated the incidence rates of acute occupational pesticide poisoning for those employed in agriculture. The findings of the study suggest the continuing problem of pesticide poisoning in the agricultural industry. The need for enhanced efforts to protect farmworkers from pesticide exposure is also discussed.
KW - Industrial toxicology
KW - Pesticides
KW - Poisoning
KW - Occupational diseases
KW - Disease incidence
KW - Agricultural laborers
KW - Research
KW - Occupational medicine
KW - United States
KW - agricultureefarmworkers
KW - pesticides
KW - poisoning
KW - surveillance
N1 - Accession Number: 35633340; Calvert, Geoffrey M. 1; Email Address: jac6@cdc.gov; Karnik, Jennifer 1; Mehler, Louise 2; Beckman, John 3; Morrissey, Barbara 4; Sievert, Jennifer 5; Barrett, Rosanna 6; Lackovic, Michelle 7; Mabee, Laura 8; Schwartz, Abby 9; Mitchell, Yvette 10; Moraga-McHaley, Stephanie 11; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute tor Occupational Safety and Health, Centers tor Disease Control and Prevention, Cincinnati, Ohio; 2: Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, California; 3: Public Health Institute, Oakland, California; 4: Office of Environmental Assessments,Washington State Department of Health, Olympia, Washington; 5: Environmental and Injury Epidemiology and Toxicology Branch, Texas Department of State Health Services, Austin,Texas; 6: Florida Department of Health,Tallahassee, Florida; 7: Louisiana Department of Health and Hospitals, New Orleans, Louisiana; 8: Office of Environmental Public Health, Oregon Department of Human Services, Portland, Oregon; 9: Division of Environmental Health, Michigan Department at Community Health, Lansing, Michigan; 10: Bureau of Occupational Health, New York State Department of Health,Troy, New York; 11: New Mexico Occupational Health Registry, University of New Mexico, Albuquerque, New Mexico; Issue Info: Dec2008, Vol. 51 Issue 12, p883; Thesaurus Term: Industrial toxicology; Thesaurus Term: Pesticides; Thesaurus Term: Poisoning; Thesaurus Term: Occupational diseases; Thesaurus Term: Disease incidence; Thesaurus Term: Agricultural laborers; Thesaurus Term: Research; Subject Term: Occupational medicine; Subject: United States; Author-Supplied Keyword: agricultureefarmworkers; Author-Supplied Keyword: pesticides; Author-Supplied Keyword: poisoning; Author-Supplied Keyword: surveillance; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 16p; Illustrations: 7 Charts, 1 Graph; Document Type: Article
L3 - 10.1002/ajim.20623
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lehman, Everett J.
AU - Hein, Misty J.
AU - Estill, Cheryl F.
T1 - Proportionate Mortality Study of the United Association of Journeymen and Apprentices of the Plumbing and Pipe Fitting Industry.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2008/12//
VL - 51
IS - 12
M3 - Article
SP - 950
EP - 963
SN - 02713586
AB - The article presents a study which examines the causes of deaths among plumbers, pipefitters, and allied traders who are members of the United Association of Journeymen and Apprentices of the Plumbing Pipe Fitting Industry of the U.S. and Canada. The study conducted proportionate mortality ratio (PMR) analysis to evaluate the deaths of union members that were selected from a computer file provided by the union. Results of the study indicate the mortality of members related to asbestos exposure.
KW - Asbestos
KW - Industrial toxicology
KW - Research
KW - Mortality
KW - Plumbers
KW - Pipe fitters
KW - Ratio analysis
KW - Occupational medicine
KW - asbestos
KW - construction
KW - pipe-fitter
KW - plumber
KW - sprinkler-fitter
KW - United Association of Journeymen & Apprentices of the Plumbing & Pipe Fitting Industry
N1 - Accession Number: 35633346; Lehman, Everett J. 1; Email Address: elehman@cdc.gov; Hein, Misty J. 1; Estill, Cheryl F. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Dec2008, Vol. 51 Issue 12, p950; Thesaurus Term: Asbestos; Thesaurus Term: Industrial toxicology; Thesaurus Term: Research; Subject Term: Mortality; Subject Term: Plumbers; Subject Term: Pipe fitters; Subject Term: Ratio analysis; Subject Term: Occupational medicine; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: construction; Author-Supplied Keyword: pipe-fitter; Author-Supplied Keyword: plumber; Author-Supplied Keyword: sprinkler-fitter ; Company/Entity: United Association of Journeymen & Apprentices of the Plumbing & Pipe Fitting Industry; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 14p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1002/ajim.20640
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105608282
T1 - Assessment of health care personnel needs for training in infection control: one size does not fit all.
AU - Knapp MB
AU - McIntyre R
AU - Sinkowitz-Cochran RL
AU - Pearson ML
Y1 - 2008/12//
N1 - Accession Number: 105608282. Language: English. Entry Date: 20090213. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Health Personnel -- Education
KW - Infection Control -- Education
KW - Professional Knowledge -- Evaluation
KW - Allied Health Personnel
KW - Convenience Sample
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Georgia
KW - Handwashing
KW - Information Needs
KW - Patient Isolation
KW - Physicians
KW - Professional Compliance
KW - Surveys
KW - Human
SP - 757
EP - 760
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 36
IS - 10
CY - New York, New York
PB - Elsevier Science
AB - To guide development of infection control education, we conducted a pilot needs assessment to determine current infection control knowledge, identify potential gaps between knowledge and practice, and identify perceived training needs among a varied group of health care personnel. A total of 23 health care personnel from various disciplines and health care settings completed the self-administered Web-based survey. Differences in knowledge and self-identified training needs were found among disciplines. Future research may well focus on further exploring specific needs of different disciplines. These results will be used to inform topics to cover in infection control curricula for clinicians, public health professionals, and allied health personnel.
SN - 0196-6553
AD - Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA.
U2 - PMID: 18834737.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105591189
T1 - Racial/ethnic and gender differences in individual workplace injury risk trajectories: 1988-1998.
AU - Berdahl TA
Y1 - 2008/12//
N1 - Accession Number: 105591189. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: Supported by the Bureau of Labor Statistics and the Center for Human Resource Research at the Ohio State University, and through the Inter University Consortium for Political and Social Research at the University of Michigan. NLM UID: 1254074.
KW - Ethnic Groups
KW - Occupational-Related Injuries -- Risk Factors
KW - Race Factors
KW - Sex Factors
KW - Blacks
KW - Career Mobility
KW - Correlational Studies
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Hispanics
KW - Insurance, Health
KW - Job Characteristics
KW - Labor Unions
KW - Linear Regression
KW - Male
KW - Occupational Diseases -- Risk Factors
KW - Panel Studies -- United States
KW - Racism
KW - Secondary Analysis
KW - United States
KW - Whites
KW - Work Environment
KW - Human
SP - 2258
EP - 2263
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 98
IS - 12
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: I examined workplace injury risk over time and across racial/ethnic and gender groups to observe patterns of change and to understand how occupational characteristics and job mobility influence these changes. METHODS: I used hierarchical generalized linear models to estimate individual workplace injury and illness risk over time ('trajectories') for a cohort of American workers who participated in the National Longitudinal Survey of Youth (1988-1998). RESULTS: Significant temporal variation in injury risk was observed across racial/ethnic and gender groups. At baseline, White men had a high risk of injury relative to the other groups and experienced the greatest decline over time. Latino men demonstrated a pattern of lower injury risk across time compared with White men. Among both Latinos and non-Latino Whites, women had lower odds of injury than did men. Non-Latino Black women's injury risk was similar to Black men's and greater than that for both Latino and non-Latino White women. Occupational characteristics and job mobility partly explained these differences. CONCLUSIONS: Disparities between racial/ethnic and gender groups were dynamic and changed over time. Workplace injury risk was associated with job dimensions such as work schedule, union representation, health insurance, job hours, occupational racial segregation, and occupational environmental hazards.
SN - 0090-0036
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. terceira.berdahl@ahrq.hhs.gov
U2 - PMID: 18235072.
DO - 10.2105/AJPH.2006.103135
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105588197
T1 - Medicare's new policy targets hospital-acquired conditions.
AU - Clancy CM
Y1 - 2008/12//
N1 - Accession Number: 105588197. Language: English. Entry Date: 20090130. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 0372403.
KW - Adverse Health Care Event
KW - Cross Infection
KW - Insurance, Health, Reimbursement
KW - Medicare -- United States
KW - Patient Safety
KW - Adverse Health Care Event -- Prevention and Control
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - United States Centers for Medicare and Medicaid Services
SP - 1001
EP - 1003
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 88
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 19054488.
DO - 10.1016/j.aorn.2008.11.022
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Baker, Brent A.
AU - Hollander, Melinda S.
AU - Mercer, Robert R.
AU - Kashon, Michael L.
AU - Cutlip, Robert G.
T1 - Adaptive stretch-shortening contractions: diminished regenerative capacity with aging.
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
Y1 - 2008/12//
VL - 33
IS - 6
M3 - Article
SP - 1181
EP - 1191
PB - Canadian Science Publishing
SN - 17155312
AB - This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading. (English) [ABSTRACT FROM AUTHOR]
AB - Cette étude se propose de déterminer les événements immédiats qui sont associés au vieillissement et qui déclenchent le remodelage et (ou) régénération du muscle jambier antérieur après une série d’actions d’étirement-contraction (SSCs). On évalue chez des rats jeunes et âgés les variations de performance musculaire et les modifications morphologiques observées 6, h, 24 h, 48 h, 72 h et 120 h après les brèves expositions aux SSCs à caractère adaptatif (n = 6 par groupe d’âge et par période de récupération). Après l’exposition au SSCs, on observe durant les 120 h d’adaptation une baisse de performance chez les rats âgés. D’après des estimations, le degré de l’œdème observé 120 h après l’exposition aux SSCs est plus prononcé chez les rats âgés que chez les jeunes rats. On observe tant chez les jeunes rats que chez les plus âgés une augmentation du marquage de la chaîne lourde de myosine en croissance (MHCdev+), signe de régénération musculaire. Cependant, on observe moins de marquage de la MHCdev+ chez les rats âgés comparativement aux jeunes rats, ce qui suggère une diminution de la capacité de remodelage et (ou) régénération chez ces premiers. D’après ces observations, la diminution de la capacité de remodelage et (ou) régénération observée avec le vieillissement semble limiter l’adaptation du muscle au chargement mécanique. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied Physiology, Nutrition & Metabolism is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLE contraction
KW - REGENERATION (Biology)
KW - AGING
KW - MORPHOLOGY
KW - MYOSIN
KW - RATS as laboratory animals
KW - aging
KW - inflammation
KW - muscle regeneration
KW - myosin heavy chain
KW - stretch-shortening contractions
KW - actions d'étirementcontraction
KW - chaîne lourde de myosine
KW - inflammation
KW - régénération musculaire
KW - vieillissement
N1 - Accession Number: 35731939; Baker, Brent A. 1 Hollander, Melinda S. 1 Mercer, Robert R. 1 Kashon, Michael L. 1 Cutlip, Robert G. 1; Email Address: rgc8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26505, USA; Source Info: Dec2008, Vol. 33 Issue 6, p1181; Subject Term: MUSCLE contraction; Subject Term: REGENERATION (Biology); Subject Term: AGING; Subject Term: MORPHOLOGY; Subject Term: MYOSIN; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: aging; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: muscle regeneration; Author-Supplied Keyword: myosin heavy chain; Author-Supplied Keyword: stretch-shortening contractions; Author-Supplied Keyword: actions d'étirementcontraction; Author-Supplied Keyword: chaîne lourde de myosine; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: régénération musculaire; Author-Supplied Keyword: vieillissement; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 2 Color Photographs, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1139/H08-110
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105599403
T1 - Adaptive stretch-shortening contractions: diminished regenerative capacity with aging.
AU - Baker BA
AU - Hollander MS
AU - Mercer RR
AU - Kashon ML
AU - Cutlip RG
Y1 - 2008/12//
N1 - Accession Number: 105599403. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. Special Interest: Nutrition; Sports Medicine. NLM UID: 101264333.
KW - Aging
KW - Muscle Contraction
KW - Muscle, Skeletal
KW - Regeneration
KW - Stretching
KW - Tibia
KW - Age Factors
KW - Analysis of Variance
KW - Animal Studies
KW - Edema
KW - Inflammation
KW - Rats
SP - 1181
EP - 1191
JO - Applied Physiology, Nutrition & Metabolism
JF - Applied Physiology, Nutrition & Metabolism
JA - APPL PHYSIOL NUTR METAB
VL - 33
IS - 6
CY - Ottawa, Ontario
PB - Canadian Science Publishing
SN - 1715-5312
AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26505
U2 - PMID: 19088776.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mohan, Ketha V.
AU - Muller, Jacqueline
AU - Atreya, Chintamani D.
T1 - Defective rotavirus particle assembly in lovastatin-treated MA104 cells.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2008/12//
VL - 153
IS - 12
M3 - Article
SP - 2283
EP - 2290
SN - 03048608
AB - Rotavirus is a non-enveloped virus that depends on cellular lipids for cell entry and associates with lipid rafts during assembly. However, the effects of cellular lipids on rotavirus assembly are still not fully understood. The present study analyzes the effects of lovastatin, an inhibitor of cholesterol biosynthesis, during rotavirus infection in MA104 cells with regard to viral growth and particle assembly. Following viral infection, a 2-log relative reduction of viral titers was observed in drug-treated cells, while viral mRNA levels in infected cells remained unaltered in both groups. Furthermore, the levels of some viral proteins in drug-treated cells were elevated. The observed discordance between the viral RNA and protein levels and the decrease in infectivity titers of viral progeny in the drug-treated cells suggested that the drug affects viral assembly, the viral proteins not being properly incorporated into virions. Transmission electron microscopic (TEM) analysis revealed that in drug-treated cells there was an increase in “empty-looking” rotavirus particles devoid of an electron-dense core as compared to the normal, electron-dense particles seen in untreated infected cells. The present study thus provides visual evidence of defective rotavirus particle assembly as a result of cholesterol depletion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUSES
KW - MESSENGER RNA
KW - ROTAVIRUS diseases
KW - DRUGS -- Effectiveness
KW - VIRAL proteins
KW - ATHEROEMBOLISM
KW - TRANSMISSION electron microscopy
N1 - Accession Number: 35920487; Mohan, Ketha V. 1,2,3; Email Address: krishna.ketha@fda.hhs.gov Muller, Jacqueline 4 Atreya, Chintamani D. 2; Affiliation: 1: Laboratory of Hepatitis Viruses, Food and Drug Administration, Bethesda, MD 20892, USA 2: Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 3: Bldg. 29A, Room 2C-15, CBER/FDA, NIH campus, 8800 Rockville Pike, Bethesda, MD 20892, USA 4: Laboratory of Vector-Borne Viral Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Dec2008, Vol. 153 Issue 12, p2283; Subject Term: ROTAVIRUSES; Subject Term: MESSENGER RNA; Subject Term: ROTAVIRUS diseases; Subject Term: DRUGS -- Effectiveness; Subject Term: VIRAL proteins; Subject Term: ATHEROEMBOLISM; Subject Term: TRANSMISSION electron microscopy; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Graph; Document Type: Article
L3 - 10.1007/s00705-008-0261-0
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Seong-Jae Kim
AU - Ohgew Kweon
AU - Jones, Richard C.
AU - Edmondson, Ricky D.
AU - Cerniglia, Carl E.
T1 - Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1.
JO - Biodegradation
JF - Biodegradation
Y1 - 2008/12//
VL - 19
IS - 6
M3 - Article
SP - 859
EP - 881
SN - 09239820
AB - Mycobacterium vanbaalenii PYR-1 is well known for its ability to degrade a wide range of high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). The genome of this bacterium has recently been sequenced, allowing us to gain insights into the molecular basis for the degradation of PAHs. The 6.5 Mb genome of PYR-1 contains 194 chromosomally encoded genes likely associated with degradation of aromatic compounds. The most distinctive feature of the genome is the presence of a 150 kb major catabolic region at positions 494 ~ 643 kb (region A), with an additional 31 kb region at positions 4,711 ~ 4,741 kb (region B), which is predicted to encode most enzymes for the degradation of PAHs. Region A has an atypical mosaic structure made of several gene clusters in which the genes for PAH degradation are complexly arranged and scattered around the clusters. Significant differences in the gene structure and organization as compared to other well-known aromatic hydrocarbon degraders including Pseudomonas and Burkholderia were revealed. Many identified genes were enriched with multiple paralogs showing a remarkable range of diversity, which could contribute to the wide variety of PAHs degraded by M. vanbaalenii PYR-1. The PYR-1 genome also revealed the presence of 28 genes involved in the TCA cycle. Based on the results, we proposed a pathway in which HMW PAHs are degraded into the β-ketoadipate pathway through protocatechuate and then mineralized to CO2 via TCA cycle. We also identified 67 and 23 genes involved in PAH degradation and TCA cycle pathways, respectively, to be expressed as proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biodegradation is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Polycyclic aromatic hydrocarbons
KW - Biodegradation
KW - Polycyclic aromatic compounds
KW - Mycobacterium
KW - Bacterial genomes
KW - Genomics
KW - Degradation
KW - Genomic analysis
KW - Mycobacterium vanbaalenii PYR-1
KW - Proteome analysis
N1 - Accession Number: 35169600; Seong-Jae Kim 1; Ohgew Kweon 1; Jones, Richard C. 2; Edmondson, Ricky D. 3,4; Cerniglia, Carl E. 1; Email Address: carl.cerniglia@hhs.fda.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA; 2: NextGen/PRS, Ann Arbor, MI 48108, USA; 3: Division of Systems Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA; 4: Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72305, USA; Issue Info: Dec2008, Vol. 19 Issue 6, p859; Thesaurus Term: Polycyclic aromatic hydrocarbons; Thesaurus Term: Biodegradation; Thesaurus Term: Polycyclic aromatic compounds; Subject Term: Mycobacterium; Subject Term: Bacterial genomes; Subject Term: Genomics; Author-Supplied Keyword: Degradation; Author-Supplied Keyword: Genomic analysis; Author-Supplied Keyword: Mycobacterium vanbaalenii PYR-1; Author-Supplied Keyword: Proteome analysis; Number of Pages: 23p; Illustrations: 3 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1007/s10532-008-9189-z
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sapsford, Kim E.
AU - Sun, Steven
AU - Francis, Jesse
AU - Sharma, Shashi
AU - Kostov, Yordan
AU - Rasooly, Avraham
T1 - A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity
JO - Biosensors & Bioelectronics
JF - Biosensors & Bioelectronics
Y1 - 2008/12//
VL - 24
IS - 4
M3 - Article
SP - 618
EP - 625
SN - 09565663
AB - Abstract: Current biodetection illumination technologies (laser, LED, tungsten lamp, etc.) are based on spot illumination with additional optics required when spatial excitation is required. Herein we describe a new approach of spatial illumination based on electroluminescence (EL) semiconductor strips available in several wavelengths, greatly simplifying the biosensor design by eliminating the need for additional optics. This work combines EL excitation with charge-coupled device (CCD) based detection (EL-CCD detector) of fluorescence for developing a simple portable detector for botulinum neurotoxin A (BoTN-A) activity analysis. A Förster Resonance Energy Transfer (FRET) activity assay for BoTN-A was used to both characterize and optimize the EL-CCD detector. The system consists of two modules: (1) the detection module which houses the CCD camera and emission filters, and (2) the excitation and sample module, containing the EL strip, the excitation filter and the 9-well sample chip. The FRET activity assay used in this study utilized a FITC/DABCYL-SNAP-25 peptide substrate in which cleavage of the substrate by BoTN-A, or its light chain derivative (LcA), produced an increase in fluorescence emission. EL-CCD detector measured limits of detection (LODs) were similar to those measured using a standard fluorescent plate reader with valves between 0.625 and 1.25nM (31–62ng/ml) for LcA and 0.313nM (45ng/ml) for the full toxin, BoTN-A. As far as the authors are aware this is the first demonstration of phosphor-based EL strips being used for the spatial illumination/excitation of a surface, coupled with CCD for point of care detection. [Copyright &y& Elsevier]
AB - Copyright of Biosensors & Bioelectronics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUORESCENCE
KW - BIOSENSORS
KW - BOTULINUM toxin
KW - SEMICONDUCTORS
KW - Biodetection
KW - Botulinum neurotoxin A
KW - CCD
KW - Electroluminescent excitation
KW - Förster resonance energy transfer (FRET)
KW - Fluorescence
KW - Point of care
N1 - Accession Number: 34648804; Sapsford, Kim E. 1 Sun, Steven 1,2 Francis, Jesse 1,2 Sharma, Shashi 3 Kostov, Yordan 2 Rasooly, Avraham 1,4; Email Address: rasoolya@mail.nih.gov; Affiliation: 1: Division of Biology, Office of Science and Engineering Laboratories, FDA, Silver Spring, MD 20993, USA 2: Center for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore MD, 21250, USA 3: Division of Microbiology, Office of Regulatory Science, Food and Drug Administration, Center for Food Safety and Applied Nutrition (CFSAN), College Park, MD 20740, USA 4: National Cancer Institute, Rockville, MD 20892, USA; Source Info: Dec2008, Vol. 24 Issue 4, p618; Subject Term: FLUORESCENCE; Subject Term: BIOSENSORS; Subject Term: BOTULINUM toxin; Subject Term: SEMICONDUCTORS; Author-Supplied Keyword: Biodetection; Author-Supplied Keyword: Botulinum neurotoxin A; Author-Supplied Keyword: CCD; Author-Supplied Keyword: Electroluminescent excitation; Author-Supplied Keyword: Förster resonance energy transfer (FRET); Author-Supplied Keyword: Fluorescence; Author-Supplied Keyword: Point of care; NAICS/Industry Codes: 334413 Semiconductor and Related Device Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.bios.2008.06.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bruening, Dustin A.
AU - Crewe, Ashlie N.
AU - Buczek, Frank L.
T1 - A simple, anatomically based correction to the conventional ankle joint center
JO - Clinical Biomechanics
JF - Clinical Biomechanics
Y1 - 2008/12//
VL - 23
IS - 10
M3 - Article
SP - 1299
EP - 1302
SN - 02680033
AB - Abstract: Background: Conventional motion analysis studies define the ankle joint center as the midpoint between the most medial and lateral aspects of the malleoli, yet research points toward a more distal joint center location. The purpose of this study was to develop and evaluate an anatomically based correction that would move the conventional ankle joint center to a more accurate location. Methods: Lower extremity radiographs from 30 pediatric patients were analyzed retrospectively. An offset between the conventional and more accurate ankle joint centers was measured and correlated to other common anatomical measures based on conventional skin mounted marker positions. The best correlated measure was used to define a simple correction factor, which was subsequently evaluated by its effect on six degree-of-freedom ankle joint translations during normal gait (n =8). Findings: Shank length was found to have the highest bivariate linear correlation (r =0.89) with the offset. Adjusting the ankle joint center using a percentage of shank length (2.7%) was also as accurate as the regression equation in predicting offset (mean error 0.6mm, or 6% offset). Adjusting the ankle joint center using this simple percentage resulted in a 25% reduction in mean ankle joint translations during normal gait. Interpretation: The accuracy of the ankle joint center can be increased through a simple, anatomically based correction. This correction may prove beneficial in some kinematic and kinetic applications requiring increased anatomical fidelity. [Copyright &y& Elsevier]
AB - Copyright of Clinical Biomechanics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANKLE wounds
KW - PEDIATRICS
KW - JUVENILE diseases
KW - RADIOGRAPHY
KW - Ankle axes
KW - Ankle joint center
KW - Gait analysis
KW - Joint translation
KW - Six-degree-of-freedom modeling
N1 - Accession Number: 35329036; Bruening, Dustin A. 1,2; Email Address: dustinb@udel.edu Crewe, Ashlie N. 3 Buczek, Frank L. 2,4; Affiliation: 1: Health, Nutrition, and Exercise Science Department, University of Delaware, Newark, DE, USA 2: Shriners Hospitals for Children-Erie, 1645 W. 8th Street, Erie, PA 16509, USA 3: Physical Therapy Department, Gannon University, Erie, PA, USA 4: National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA; Source Info: Dec2008, Vol. 23 Issue 10, p1299; Subject Term: ANKLE wounds; Subject Term: PEDIATRICS; Subject Term: JUVENILE diseases; Subject Term: RADIOGRAPHY; Author-Supplied Keyword: Ankle axes; Author-Supplied Keyword: Ankle joint center; Author-Supplied Keyword: Gait analysis; Author-Supplied Keyword: Joint translation; Author-Supplied Keyword: Six-degree-of-freedom modeling; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.clinbiomech.2008.08.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dayan, Gustavo H.
AU - Rubin, Steven
T1 - Mumps Outbreaks in Vaccinated Populations: Are Available Mumps Vaccines Effective Enough to Prevent Outbreaks?
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/12//12/1/2008
VL - 47
IS - 11
M3 - Article
SP - 1458
EP - 1467
SN - 10584838
AB - Increased reports of mumps in vaccinated populations prompted a review of the performance of mumps vaccines. The effectiveness of prior vaccination with 1 dose of vaccine ranged from 72.8% to 91% for the Jeryl Lynn strain, from 54.4% to 93% for the Urabe strain, and from 0% to 33% for the Rubini strain. Vaccine effectiveness after 2 doses of mumps vaccine was reported in 3 outbreaks and ranged from 91% to 94.6%. There was evidence of waning immunity, which is a likely factor in mumps outbreaks, aggravated by possible antigenic differences between the vaccine strain and outbreak strains. Inadequate vaccine coverage or use of the Rubini vaccine strain accounted for the majority of outbreaks reviewed; however, some outbreaks could not be prevented, despite high vaccination coverage with 2 doses of the Jeryl Lynn vaccine strain. Our findings indicate the need for more-effective mumps vaccines and/or for review of current vaccination policies to prevent future outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Epidemics
KW - Vaccination
KW - Immunity
KW - Mumps
KW - Strain (Physiology)
KW - Immunogenetics
KW - Antigenic determinants
KW - Bacterial vaccines
KW - Preventive medicine
N1 - Accession Number: 35267840; Dayan, Gustavo H. 1; Rubin, Steven 2; Email Address: Steven.Rubin@fda.hhs.gov; Affiliations: 1: Clinical Department, Sanofi Pasteur, Swiftwater, Pennsylvania; 2: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland; Issue Info: 12/1/2008, Vol. 47 Issue 11, p1458; Thesaurus Term: VACCINATION; Thesaurus Term: Epidemics; Thesaurus Term: Vaccination; Thesaurus Term: Immunity; Subject Term: Mumps; Subject Term: Strain (Physiology); Subject Term: Immunogenetics; Subject Term: Antigenic determinants; Subject Term: Bacterial vaccines; Subject Term: Preventive medicine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1086/591196
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Reuter, Gábor
AU - Boldizsár, Ákos
AU - Kiss, István
AU - Pankovics, Péter
T1 - Candidate New Species of Kobuvirus in Porcine Hosts.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2008/12//
VL - 14
IS - 12
M3 - Letter
SP - 1968
EP - 1970
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - A letter to the editor is presented about new species of Kobuvirus in porcine hosts.
KW - Viruses
KW - Letters to the editor
N1 - Accession Number: 35654171; Reuter, Gábor 1; Email Address: reuter.gabor@baranya.antsz.hu; Boldizsár, Ákos 1; Kiss, István 2; Pankovics, Péter 1; Affiliations: 1: ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary; 2: Veterinary Diagnostic Directorate, Debrecen, Hungary; Issue Info: Dec2008, Vol. 14 Issue 12, p1968; Thesaurus Term: Viruses; Subject Term: Letters to the editor; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Letter
L3 - 10.3201/eid1412.080797
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105583619
T1 - Candidate new species of kobuvirus in porcine hosts.
AU - Reuter G
AU - Boldizsár A
AU - Kiss I
AU - Pankovics P
Y1 - 2008/12//
N1 - Accession Number: 105583619. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article; letter. Journal Subset: Biomedical; USA. NLM UID: 9508155.
KW - Picornavirus Infections
KW - RNA Viruses -- Classification
KW - RNA Viruses
KW - Swine
KW - Animals
KW - Documentation
KW - Evolution
KW - Feces
KW - Hungary
KW - Immunity
KW - Sequence Analysis
KW - Swine -- Microbiology
SP - 1968
EP - 1970
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
JA - EMERGING INFECT DIS
VL - 14
IS - 12
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
SN - 1080-6040
AD - ANTSZ Regional Institute of State Public Health Service, Pécs, Hungary (G. Reuter, A. Boldizsár, P. Pankovics); and Veterinary Diagnostic Directorate, Debrecen, Hungary (I. Kiss).
U2 - PMID: 19046542.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Nan Mei
AU - Lei Guo
AU - Jo Tseng
AU - Dial, Stacey L.
AU - Liao, Wayne
AU - Manjanatha, Mugimane G.
T1 - Gene Expression Changes Associated with Xenobiotic Metabolism Pathways in Mice Exposed to Acrylamide.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2008/12//
VL - 49
IS - 9
M3 - Article
SP - 741
EP - 745
SN - 08936692
AB - The article discusses the study using groups of male mice to investigate the previous discovery of acrylamide (AA) in a variety of fried foods which alarmed the public due to health concerns. It reveals on the gene ontology analysis that the principle pathways affected by AA were xenobiotic metabolism by cytochrome P450 and glutathione metabolism are positively affected by the exposure. It adds that the outcomes provide information about AA metabolism and further insight about the molecular mechanisms involved in AA-induced toxicity.
KW - Acrylamide
KW - Toxicity testing
KW - Mice
KW - Xenobiotics
KW - Fried food
KW - Gene expression
KW - Ontology
KW - Cytochromes
KW - Metabolism
KW - acrylamide
KW - gene expression
KW - metabolism pathway
N1 - Accession Number: 35897366; Nan Mei 1; Email Address: nan.mei@fda.hhs.gov; Lei Guo 2; Jo Tseng 3; Dial, Stacey L. 2; Liao, Wayne 3; Manjanatha, Mugimane G. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas; 2: Division of Systems Toxicology, National Center for Toxicological Research, - Jefferson, Arkansas; 3: PhalanxBio Inc., 1400 Page Mill Road, Palo Alto, California; Issue Info: Dec2008, Vol. 49 Issue 9, p741; Thesaurus Term: Acrylamide; Thesaurus Term: Toxicity testing; Thesaurus Term: Mice; Thesaurus Term: Xenobiotics; Subject Term: Fried food; Subject Term: Gene expression; Subject Term: Ontology; Subject Term: Cytochromes; Subject Term: Metabolism; Author-Supplied Keyword: acrylamide; Author-Supplied Keyword: gene expression; Author-Supplied Keyword: metabolism pathway; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1002/em.20429
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nishikawa, Kunihito
AU - Takahashi, Ken
AU - Karjalainen, Antti
AU - Chi-Pang Wen
AU - Furuya, Sugio
AU - Hoshuyama, Tsutomu
AU - Todoroki, Miwako
AU - Kiyomoto, Yoshifumi
AU - Wilson, Donald
AU - Higashi, Toshiaki
AU - Ohtaki, Megu
AU - Guowei Pan
AU - Wagner, Gregory
T1 - Recent Mortality from Pleural Mesothelioma, Historical Patterns of Asbestos Use, and Adoption of Bans: A Global Assessment.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2008/12//
VL - 116
IS - 12
M3 - Article
SP - 1675
EP - 1680
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: In response to the health risks posed by asbestos exposure, some countries have imposed strict regulations and adopted bans, whereas other countries have intervened less and continue to use varying quantities of asbestos. OBJECTIVES: This study was designed to assess, on a global scale, national experiences of recent mortality from pleural mesothelioma, historical trends in asbestos use, adoption of bans, and their possible interrelationships. METHODS: For 31 countries with available data, we analyzed recent pleural mesothelioma (International Classification of Diseases, 10th Revision) mortality rates (MRs) using age-adjusted period MRs (deaths/million/year) from 1996 to 2005. We calculated annual percent changes (APCs) in age-adjusted MRs to characterize trends during the period. We characterized historical patterns of asbestos use by per capita asbestos use (kilograms per capita/year) and the status of national bans. RESULTS: Period MRs increased with statistical significance in five countries, with marginal significance in two countries, and were equivocal in 24 countries (five countries in Northern and Western Europe recorded negative APC values). Countries adopting asbestos bans reduced use rates about twice as fast as those not adopting bans. Turning points in use preceded bans. Change in asbestos use during 1970--1985 was a significant predictor of APC in mortality for pleural mesothelioma, with an adjusted R2 value of 0.47 (p < 0.0001). CONCLUSIONS: The observed disparities in global mesothelioma trends likely relate to country-to-country disparities in asbestos use trends. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Asbestos -- Toxicology
KW - Asbestos -- Law & legislation
KW - Data analysis
KW - Epidemiology -- Research
KW - Mesothelioma
KW - Mortality -- Statistics
KW - Lungs -- Cancer -- Risk factors
KW - asbestos
KW - asbestos-related diseases
KW - ban
KW - epidemiology
KW - lung cancer
KW - mesothelioma
KW - mortality
KW - occupational cancer
KW - pleural mesothelioma
N1 - Accession Number: 35600471; Nishikawa, Kunihito 1; Takahashi, Ken 1; Email Address: ktaka@med.uoeh-u.ac.jp; Karjalainen, Antti 2; Chi-Pang Wen 3; Furuya, Sugio 4; Hoshuyama, Tsutomu 1; Todoroki, Miwako 1; Kiyomoto, Yoshifumi 1; Wilson, Donald 1; Higashi, Toshiaki 5; Ohtaki, Megu 6; Guowei Pan 7; Wagner, Gregory 8; Affiliations: 1: Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu City, Japan; 2: Finnish Institute of Occupational Health, Helsinki, Finland; 3: Centre for Health Policy Research and Development, National Health Research Institutes, Taiwan; 4: Japan Occupational Safety and Health Resource Centre, Tokyo, Japan; 5: Department of Work, Systems, and Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu City, Japan; 6: Department of Environmetrics and Biometrics, Hiroshima University, Hiroshima, Japan; 7: Department of Environmental Epidemiology, Liaoning Provincial Centre for Disease Prevention and Control, Shenyang, People's Republic of China; 8: U.S. National Institute for Occupational Safety and Health, Washington, DC, USA; Issue Info: Dec2008, Vol. 116 Issue 12, p1675; Thesaurus Term: RESEARCH; Thesaurus Term: Asbestos -- Toxicology; Thesaurus Term: Asbestos -- Law & legislation; Thesaurus Term: Data analysis; Thesaurus Term: Epidemiology -- Research; Subject Term: Mesothelioma; Subject Term: Mortality -- Statistics; Subject Term: Lungs -- Cancer -- Risk factors; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: asbestos-related diseases; Author-Supplied Keyword: ban; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: lung cancer; Author-Supplied Keyword: mesothelioma; Author-Supplied Keyword: mortality; Author-Supplied Keyword: occupational cancer; Author-Supplied Keyword: pleural mesothelioma; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 212394 Asbestos mining; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105498788
T1 - Record-linkage and capture-recapture analysis to estimate the incidence and completeness of reporting of tuberculosis in England 1999-2002.
AU - VAN Hest NA
AU - Story A
AU - Grant AD
AU - Antoine D
AU - Crofts JP
AU - Watson JM
Y1 - 2008/12//
N1 - Accession Number: 105498788. Language: English. Entry Date: 20090417. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Disease Surveillance
KW - Informatics
KW - Models, Statistical
KW - Tuberculosis -- Epidemiology
KW - Disease Surveillance -- Standards
KW - England
KW - Incidence
KW - Informatics -- Standards
KW - Population -- Methods
KW - Human
SP - 1606
EP - 1616
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 136
IS - 12
PB - Cambridge University Press
AB - In 1999 the Enhanced Tuberculosis Surveillance (ETS) system was introduced in the United Kingdom to strengthen surveillance of tuberculosis (TB). The aim of this study was to assess the use of record-linkage and capture-recapture methodology for estimating the completeness of TB reporting in England between 1999 and 2002. Due to the size of the TB data sources sophisticated record-linkage software was required and the proportion of false-positive cases among unlinked hospital-derived TB records was estimated through a population mixture model. This study showed that record-linkage of TB data sources and cross-validation with additional TB-related datasets improved data quality as well as case ascertainment. Since the introduction of ETS observed completeness of notification in England has increased and the results were consistent with expected levels of under-notification. Completeness of notification estimated by a log-linear capture-recapture model was highly inconsistent with prior estimates and the validity of this methodology was further examined.
SN - 0950-2688
AD - Tuberculosis Control Section, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands. vanhestr@ggd.rotterdam.nl
U2 - PMID: 18346285.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105591332
T1 - Kinematics and kinetics of gait on stilts: identification of risk factors associated with construction stilt use.
AU - Chiou SS
AU - Pan CS
AU - Bhattacharya A
Y1 - 2008/12//
N1 - Accession Number: 105591332. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Construction Industry -- Equipment and Supplies
KW - Gait
KW - Kinematics
KW - Kinetics
KW - Adult
KW - Analysis of Variance
KW - Body Weights and Measures
KW - Comparative Studies
KW - Descriptive Statistics
KW - Male
KW - Motion Analysis Systems
KW - Multivariate Analysis of Variance
KW - Post Hoc Analysis
KW - Repeated Measures
KW - Human
SP - 1814
EP - 1829
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 51
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study investigated kinematics and kinetic strategies and identified risk factors associated with gait on stilts. A six-camera motion-analysis system and two force platforms were used to test 20 construction workers for straight walking or turning, with or without carrying tools while wearing safety shoes or stilts at different heights. The results indicated that gait on stilts is characterised by increases in stride length, step width and the percentage of double support period, decreases in cadence, minimum foot clearance and a weaker heel-strike and push-off. Stilts place greater joint loadings on lower extremities to compensate for the added weight and limitation in joint mobility. Smaller foot clearances found for gait on stilts constitute an increased risk for tripping over obstacles. Workers may need to avoid prolonged use of stilts to alleviate stresses on the joints. This study was conducted to determine to what extent stilts alter the gait strategies and to explain the compensatory movements. Prior to this study, there has been little substantive research to evaluate the stresses and potential injuries associated with stilts.
SN - 0014-0139
AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
U2 - PMID: 18608480.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105591340
T1 - Footwear effects on walking balance at elevation.
AU - Simeonov P
AU - Hsiao H
AU - Powers J
AU - Ammons D
AU - Amendola A
AU - Kau T
AU - Cantis D
Y1 - 2008/12//
N1 - Accession Number: 105591340. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Balance, Postural
KW - Construction Industry
KW - Equipment Design
KW - Shoes
KW - Walking
KW - Adult
KW - Analysis of Variance
KW - Athletic Shoes
KW - Body Weights and Measures
KW - Comfort -- Evaluation
KW - Comparative Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Kinematics -- Evaluation
KW - Male
KW - Middle Age
KW - Motion Analysis Systems
KW - Multivariate Analysis of Variance
KW - Perception -- Evaluation
KW - Post Hoc Analysis
KW - Questionnaires
KW - Repeated Measures
KW - Statistical Significance
KW - Virtual Reality
KW - Visual Analog Scaling
KW - West Virginia
KW - Human
SP - 1885
EP - 1905
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 51
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The study evaluated the effects of shoe style on workers' instability during walking at elevation. Twenty-four construction workers performed walking tasks on roof planks in a surround-screen virtual reality system, which simulated a residential roof environment. Three common athletic and three work shoe styles were tested on wide, narrow and tilted planks on a simulated roof and on an unrestricted surface at simulated ground. Dependent variables included lateral angular velocities of the trunk and the rear foot, as well as the workers' rated perceptions of instability. The results demonstrated that shoe style significantly affected workers walking instability at elevated work environments. The results highlighted two major shoe-design pathways for improving walking balance at elevation: enhancing rear foot motion control; and improving ankle proprioception. This study also outlined some of the challenges in optimal shoe selection and specific shoe-design needs for improved walking stability during roof work. The study adds to the knowledge in the area of balance control, by emphasising the role of footwear as a critical human-support surface interface during work on narrow surfaces at height. The results can be used for footwear selection and improvements to reduce risk of falls from elevation.
SN - 0014-0139
AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
U2 - PMID: 19034784.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105591334
T1 - Evaluation of a comprehensive slip, trip and fall prevention programme for hospital employees.
AU - Bell JL
AU - Collins JW
AU - Wolf L
AU - Grönqvist R
AU - Chiou S
AU - Chang W
AU - Sorock GS
AU - Courtney TK
AU - Lombardi DA
AU - Evanoff B
Y1 - 2008/12//
N1 - Accession Number: 105591334. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Accidental Falls -- Epidemiology
KW - Accidental Falls -- Prevention and Control
KW - Occupational-Related Injuries -- Epidemiology
KW - Occupational-Related Injuries -- Prevention and Control
KW - Personnel, Health Facility
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Coding
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Female
KW - Injury Pattern -- Evaluation
KW - Male
KW - Middle Age
KW - Occupational Health
KW - Organizations, Nonprofit
KW - Poisson Distribution
KW - Pretest-Posttest Design
KW - Prospective Studies
KW - Record Review
KW - Sex Factors
KW - Worker's Compensation
KW - Human
SP - 1906
EP - 1925
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 51
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In 2007, the Bureau of Labor Statistics reported that the incidence rate of lost workday injuries from slips, trips and falls (STFs) on the same level in hospitals was 35.2 per 10,000 full-time equivalents (FTE), which was 75% greater than the average rate for all other private industries combined (20.2 per 10,000 FTEs). The objectives of this 10-year (1996-2005) longitudinal study were to: 1) describe occupational STF injury events in hospitals; 2) evaluate the effectiveness of a comprehensive programme for reducing STF incidents among hospital employees. The comprehensive prevention programme included analysis of injury records to identify common causes of STFs, on-site hazard assessments, changes to housekeeping procedures and products, introduction of STF preventive products and procedures, general awareness campaigns, programmes for external ice and snow removal, flooring changes and slip-resistant footwear for certain employee subgroups. The hospitals' total STF workers' compensation claims rate declined by 58% from the pre-intervention (1996-1999) rate of 1.66 claims per 100 FTE to the post-intervention (2003-2005) time period rate of 0.76 claims per 100 FTE (adjusted rate ratio = 0.42, 95% CI: 0.33-0.54). STFs due to liquid contamination (water, fluid, slippery, greasy and slick spots) were the most common cause (24%) of STF claims for the entire study period 1996-2005. Food services, transport/emergency medical service and housekeeping staff were at highest risk of a STF claim in the hospital environment. Nursing and office administrative staff generated the largest numbers of STF claims. STF injury events in hospitals have a myriad of causes and the work conditions in hospitals are diverse. This research provides evidence that implementation of a broad-scale prevention programme can significantly reduce STF injury claims.
SN - 0014-0139
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, USA.
U2 - PMID: 18932056.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105611904
T1 - Transformations in collaborative healthcare.
AU - Power AK
AU - Chawla N
Y1 - 2008/12//
N1 - Accession Number: 105611904. Language: English. Entry Date: 20090220. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9610836.
KW - Collaboration
KW - Health Care Delivery, Integrated
KW - Mental Health Services -- Administration
KW - Primary Health Care -- Administration
KW - Health Services Accessibility
KW - Mental Health Services -- Trends
KW - Models, Theoretical
KW - Multidisciplinary Care Team
KW - Patient Centered Care
KW - Primary Health Care -- Trends
KW - Recovery
SP - 459
EP - 465
JO - Families, Systems & Health: The Journal of Collaborative Family HealthCare
JF - Families, Systems & Health: The Journal of Collaborative Family HealthCare
JA - FAM SYST HEALTH
VL - 26
IS - 4
CY - Washington, District of Columbia
PB - American Psychological Association
AB - This article describes federal initiatives from the Substance Abuse and Mental Health Services Administration (SAMHSA) aimed at transforming mental health systems towards integration with primary care, discusses potential barriers to integration and how collaborators are thinking about overcoming these barriers, and shares success stories from two integration initiatives that have worked in a health plan in Colorado and an initiative in Canada. (PsycINFO Database Record (c) 2009 APA, all rights reserved)
SN - 1091-7527
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, 1 Choke Cherry Road, Rockville, MD 20857; tpowers@umassd.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taitt, Chris R.
AU - Malanoski, Anthony P.
AU - Baochuan Lin
AU - Stenger, David A.
AU - Ligler, Frances S.
AU - Kusterbeck, Anne W.
AU - Anderson, George P.
AU - Harmon, Sue E.
AU - Shriver-Lake, Lisa C.
AU - Pollack, Steven K.
AU - Lennon, Denise M.
AU - Lobo-Menendez, Fe
AU - Zheng Wang
AU - Schnur, Joel M.
T1 - Discrimination between biothreat agents and ‘near neighbor’ species using a resequencing array.
JO - FEMS Immunology & Medical Microbiology
JF - FEMS Immunology & Medical Microbiology
Y1 - 2008/12//
VL - 54
IS - 3
M3 - Article
SP - 356
EP - 364
SN - 09288244
AB - Timely identification of biothreat organisms from large numbers of clinical or environmental samples in potential outbreak or attack scenario is critical for effective diagnosis and treatment. This study aims to evaluate the potential of resequencing arrays for this purpose. Albeit suboptimal, this report demonstrated that respiratory pathogen microarray version 1 can identify Bacillus anthracis, Francisella tularensis, Yersinia pestis and distinguish them from benign ‘near neighbor’ species in a single assay. Additionally, the sequence information can discriminate strains and possibly the sources of the strains. With further development, it is possible to use resequencing microarrays for biothreat surveillance. [ABSTRACT FROM AUTHOR]
AB - Copyright of FEMS Immunology & Medical Microbiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - DNA microarrays
KW - BACILLUS anthracis
KW - FRANCISELLA tularensis
KW - YERSINIA pestis
KW - DIAGNOSIS
KW - THERAPEUTICS
KW - SPECIES
KW - ASSAYING
KW - Bacillus anthracis
KW - biothreat
KW - Francisella tularensis
KW - resequencing microarray
KW - single nucleotide polymorphism
KW - Yersinia pestis
N1 - Accession Number: 35198985; Taitt, Chris R. 1 Malanoski, Anthony P. 1 Baochuan Lin 1; Email Address: baochuan.lin@nrl.navy.mil Stenger, David A. 1 Ligler, Frances S. 1 Kusterbeck, Anne W. 1 Anderson, George P. 1 Harmon, Sue E. 2 Shriver-Lake, Lisa C. 1 Pollack, Steven K. 3 Lennon, Denise M. 4 Lobo-Menendez, Fe 4 Zheng Wang 1 Schnur, Joel M. 5; Affiliation: 1: Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA. 2: Medical Modernization Division, Office of Air Force Surgeon General, Bolling Air Force Base, Washington, DC, USA. 3: Division of Chemistry and Materials Sciences, Food and Drug Administration, Rockville, MD 20857, USA. 4: Air Force Institute for Occupational Health, Chemistry Division, TX, USA. 5: College of Science, George Mason University, 4400 University Drive, MS 5C3, USA.; Source Info: Dec2008, Vol. 54 Issue 3, p356; Subject Term: PATHOGENIC microorganisms; Subject Term: DNA microarrays; Subject Term: BACILLUS anthracis; Subject Term: FRANCISELLA tularensis; Subject Term: YERSINIA pestis; Subject Term: DIAGNOSIS; Subject Term: THERAPEUTICS; Subject Term: SPECIES; Subject Term: ASSAYING; Author-Supplied Keyword: Bacillus anthracis; Author-Supplied Keyword: biothreat; Author-Supplied Keyword: Francisella tularensis; Author-Supplied Keyword: resequencing microarray; Author-Supplied Keyword: single nucleotide polymorphism; Author-Supplied Keyword: Yersinia pestis; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1111/j.1574-695X.2008.00486.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105577108
T1 - Measuring hospital inefficiency: the effects of controlling for quality and patient burden of illness.
AU - Mutter RL
AU - Rosko MD
AU - Wong HS
Y1 - 2008/12//
N1 - Accession Number: 105577108. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Economic Aspects of Illness
KW - Hospitals -- Standards
KW - Organizational Efficiency -- Statistics and Numerical Data
KW - Quality of Health Care
KW - Algorithms
KW - Clinical Indicators
KW - Statistics
KW - Surveys
KW - United States
KW - Human
SP - 1992
EP - 2013
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 43
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD,
U2 - PMID: 18783458.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105577099
T1 - The impact of medical errors on ninety-day costs and outcomes: an examination of surgical patients.
AU - Encinosa WE
AU - Hellinger FJ
Y1 - 2008/12//
N1 - Accession Number: 105577099. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Outcome Assessment
KW - Treatment Errors -- Economics
KW - Adolescence
KW - Adult
KW - Ambulatory Care -- Utilization
KW - Audit
KW - Female
KW - Health Care Costs -- Trends
KW - Linear Regression
KW - Male
KW - Middle Age
KW - Mortality -- Trends
KW - Readmission -- Economics
KW - Safety
KW - United States
KW - Human
SP - 2067
EP - 2085
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 43
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 and
U2 - PMID: 18662169.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Caruso, Claire C.
AU - Waters, Thomas R.
T1 - A Review of Work Schedule Issues and Musculoskeletal Disorders with an Emphasis on the Healthcare Sector.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/12//
VL - 46
IS - 6
M3 - Article
SP - 523
EP - 534
SN - 00198366
AB - The article assess the research progress and gaps across studies that examined the relationship between demanding work schedules and musculoskeletal disorders (MSDs) outcomes, because MSD is a significant cause of morbidity in healthcare workers. In addition, there are relatively few studies that have adequately examined the relationship of work schedules and musculoskeletal outcomes.
KW - RESEARCH
KW - DISEASES
KW - Working hours
KW - Musculoskeletal system
KW - Flextime
KW - Medical personnel
KW - Employee health promotion
KW - Shift systems
KW - Extended work periods
KW - Long work hours
KW - Musculoskeletal disorders
KW - Review
KW - Shift work
KW - Work schedule tolerance
KW - Working hours
N1 - Accession Number: 35945322; Caruso, Claire C. 1; Waters, Thomas R. 1; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226-1998, USA; Issue Info: 2008, Vol. 46 Issue 6, p523; Thesaurus Term: RESEARCH; Thesaurus Term: DISEASES; Subject Term: Working hours; Subject Term: Musculoskeletal system; Subject Term: Flextime; Subject Term: Medical personnel; Subject Term: Employee health promotion; Subject Term: Shift systems; Author-Supplied Keyword: Extended work periods; Author-Supplied Keyword: Long work hours; Author-Supplied Keyword: Musculoskeletal disorders; Author-Supplied Keyword: Review; Author-Supplied Keyword: Shift work; Author-Supplied Keyword: Work schedule tolerance; Author-Supplied Keyword: Working hours; Number of Pages: 12p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yamasaki, Akiko
AU - Araki, Shunichi
AU - Sakai, Ryoji
AU - Yokoyama, Kazuhito
AU - Voorhees, A. Scott
T1 - Suicide Mortality of Young, Middle-aged and Elderly Males and Females in Japan for the Years 1953-96: Time Series Analysis for the Effects of Unemployment, Female Labour Force, Young and Aged Population, Primary Industry and Population Density.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/12//
VL - 46
IS - 6
M3 - Article
SP - 541
EP - 549
SN - 00198366
AB - The article highlights the multiple regression analysis on the effects of nine social life indicators on age-adjusted and age-specific annual suicide mortality of male and female Japanese population in 1953-1956 in Japan. The regression analysis shows that unemployment rate is related to the age-adjusted mortality in both males and females. In addition, the female labour force participation is positively related to the male mortality.
KW - RESEARCH
KW - Suicide
KW - Time series analysis
KW - Regression analysis
KW - Unemployment
KW - Labor supply
KW - Mortality
KW - Mathematical statistics
KW - Japan
KW - Female labour force
KW - Suicide
KW - Young and aged population
N1 - Accession Number: 35945324; Yamasaki, Akiko 1,2; Email Address: otsu-tky@umin.ac.jp; Araki, Shunichi 3; Sakai, Ryoji 4; Yokoyama, Kazuhito 5; Voorhees, A. Scott 6; Affiliations: 1: Department of Health Promotion & Human Behaviour, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan; 2: Osaka University Research Institute for Sustainability Science, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan; 3: National Institute of Occupational Safety and Health, Umezono 1-4-6, Kiyose, Tokyo 204-0024, Japan; 4: Union of Risk Management for Preventive Medicine, 4-36-2-103 Hongo, Bunkyoku, Tokyo 113-0033, Japan; 5: Department of Public Health, School of Medicine, Mie University, Mie 514-8507, Japan; 6: Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Issue Info: 2008, Vol. 46 Issue 6, p541; Thesaurus Term: RESEARCH; Subject Term: Suicide; Subject Term: Time series analysis; Subject Term: Regression analysis; Subject Term: Unemployment; Subject Term: Labor supply; Subject Term: Mortality; Subject Term: Mathematical statistics; Subject: Japan; Author-Supplied Keyword: Female labour force; Author-Supplied Keyword: Suicide; Author-Supplied Keyword: Young and aged population; NAICS/Industry Codes: 561320 Temporary Help Services; Number of Pages: 9p; Illustrations: 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rakheja, Subhash
AU - Mandapuram, Santosh
AU - Dong, Ren G.
T1 - Energy Absorption of Seated Occupants Exposed to Horizontal Vibration and Role of Back Support Condition.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/12//
VL - 46
IS - 6
M3 - Article
SP - 550
EP - 566
SN - 00198366
AB - The article highlights the research on the absorbed power characteristics of seated human subjects under fore-aft (x-axis) and lateral (y-axis) vibration. The research is conducted through measurements of dynamic interactions at the two driving-points formed by the body and the seat pan, and upper body and the backrest. In addition, the responses suggest strong contributions due to back support and direction and magnitude of vibration.
KW - RESEARCH
KW - Research
KW - Sitting position
KW - Human mechanics
KW - Human experimentation
KW - Vibration (Mechanics)
KW - Magnitude estimation
KW - METHODOLOGY
KW - Ergonomics
KW - Absorbed power
KW - Back support condition
KW - Body-seat interactions
KW - Horizontal vibration
KW - Seat height
KW - Upper body-backrest interactions
N1 - Accession Number: 35945325; Rakheja, Subhash 1; Mandapuram, Santosh 1; Dong, Ren G. 2; Affiliations: 1: ConCAVE Research Centre, Mechanical & Industrial Engineering, Concordia University, 1455 de Maisonneuve West, Montreal, Quebec H3G 1M8, Canada; 2: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA; Issue Info: 2008, Vol. 46 Issue 6, p550; Thesaurus Term: RESEARCH; Thesaurus Term: Research; Subject Term: Sitting position; Subject Term: Human mechanics; Subject Term: Human experimentation; Subject Term: Vibration (Mechanics); Subject Term: Magnitude estimation; Subject Term: METHODOLOGY; Subject Term: Ergonomics; Author-Supplied Keyword: Absorbed power; Author-Supplied Keyword: Back support condition; Author-Supplied Keyword: Body-seat interactions; Author-Supplied Keyword: Horizontal vibration; Author-Supplied Keyword: Seat height; Author-Supplied Keyword: Upper body-backrest interactions; Number of Pages: 17p; Illustrations: 8 Charts, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shibata, Nobuyuki
AU - Hosoya, Naoki
AU - Maeda, Setsuo
T1 - Establishment of One-axis Vibration Test System for Measurement of Biodynamic Response of Human Hand-arm System.
JO - Industrial Health
JF - Industrial Health
Y1 - 2008/12//
VL - 46
IS - 6
M3 - Article
SP - 629
EP - 634
SN - 00198366
AB - The article highlights the study on the characteristics of an instrumented handle and the performance and measurement accuracy of the system applied to dynamic response measurement in Japan. The author stated that a single axis hand-arm vibration system has been installed in the Japan National Institute of Occupational Safety and Health (NIOSH). The study suggests that the hand-arm vibration test system can be used to measure biodynamic response parameters of the human hand-arm system.
KW - Industrial safety
KW - Vibration (Mechanics)
KW - Test systems
KW - Industrial productivity
KW - Japan
KW - Apparent mass
KW - Dynamic response
KW - Hand-arm vibration
KW - ISO10068
KW - Single-axis vibration
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 35945333; Shibata, Nobuyuki 1; Hosoya, Naoki 2; Maeda, Setsuo 1; Affiliations: 1: Department of Research Planning and Coordination, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Department of Mechanical Engineering II, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto, Tokyo 135-8548, Japan; Issue Info: 2008, Vol. 46 Issue 6, p629; Thesaurus Term: Industrial safety; Subject Term: Vibration (Mechanics); Subject Term: Test systems; Subject Term: Industrial productivity; Subject: Japan; Author-Supplied Keyword: Apparent mass; Author-Supplied Keyword: Dynamic response; Author-Supplied Keyword: Hand-arm vibration; Author-Supplied Keyword: ISO10068; Author-Supplied Keyword: Single-axis vibration ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 6p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105450222
T1 - Costly hospital readmissions and complex chronic illness.
AU - Friedman B
AU - Jiang HJ
AU - Elixhauser A
Y1 - 2008///Winter2008
N1 - Accession Number: 105450222. Language: English. Entry Date: 20090403. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Chronic Disease
KW - Comorbidity
KW - Health Care Costs
KW - Readmission
KW - Administrative Research
KW - Adult
KW - Conceptual Framework
KW - Cost Savings
KW - Descriptive Statistics
KW - Disease Management -- Methods
KW - Inpatients
KW - Insurance, Health -- Methods
KW - Logistic Regression
KW - Outcomes (Health Care)
KW - Patient Discharge -- Statistics and Numerical Data
KW - Physician Incentive Plans
KW - Secondary Analysis
KW - Severity of Illness
KW - Human
SP - 408
EP - 421
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 45
IS - 4
PB - Sage Publications Inc.
AB - People with multiple chronic conditions account for a large and disproportionate share of total health care costs. One aspect of the high cost for such patients is a relatively high number of hospital admissions per year. This study aims to clarify how the rate of hospital readmissions and hospital cost per person in a year depend on a patient's number of different chronic conditions ('complexity'), severity of illness, principal diagnosis at discharge, payer group, and other variables. We use a database of all hospital discharges for adults in six states. The number of different chronic conditions has a smoothly increasing effect on readmissions and cost per year, and there are notable differences by payer group. We offer illustrations of the potential savings from reducing total inpatient cost and readmissions in narrowly targeted populations with the most complex problems. The study's methods and descriptive data potentially could be useful for health plans and their sponsors (employers, government) when they design strategies to address the high cost of complex chronic illness.
SN - 0046-9580
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. Bernard.friedman@ahrq.hhs.gov
U2 - PMID: 19209836.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Friedman, Bernard
AU - Jiang, H. Joanna
AU - Elixhauser, Anne
T1 - Costly Hospital Readmissions and Complex Chronic Illness.
JO - Inquiry (00469580)
JF - Inquiry (00469580)
Y1 - 2008///Winter2008
VL - 45
IS - 4
M3 - Article
SP - 408
EP - 421
SN - 00469580
AB - People with multiple chronic conditions account for a large and disproportionate share of total health care costs. One aspect of the high cost for such patients is a relatively high number of hospital admissions per year. This study aims to clarify how the rate of hospital readmissions and hospital cost per person in a year depend on a patient's number of different chronic conditions ("complexity"), severity of illness, principal diagnosis at discharge, payer group, and other variables.We use a database of all hospital discharges for adults in six states. The number of different chronic conditions has a smoothly increasing effect on readmissions and cost per year, and there are notable differences by payer group. We offer illustrations of the potential savings from reducing total inpatient cost and readmissions in narrowly targeted populations with the most complex problems. The study's methods and descriptive data potentially could be useful for health plans and their sponsors (employers, government) when they design strategies to address the high cost of complex chronic illness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inquiry (00469580) is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITALS
KW - HEALTH insurance
KW - MEDICAL care
KW - MEDICAL care costs
KW - CHRONIC diseases
KW - ADMISSION & discharge
KW - MEDICAL policy
N1 - Accession Number: 36400524; Friedman, Bernard 1; Email Address: Bernard.friedman@ahrq.hhs.gov; Jiang, H. Joanna; Elixhauser, Anne 2; Affiliations: 1: Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality (AHRQ); 2: AHRQ, 540 Gaither Road, Rockville, MD 20850; Issue Info: Winter2008, Vol. 45 Issue 4, p408; Thesaurus Term: HOSPITALS; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICAL care; Subject Term: MEDICAL care costs; Subject Term: CHRONIC diseases; Subject Term: ADMISSION & discharge; Subject Term: MEDICAL policy; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 14p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Li, Jinxi
AU - Shefcheck, Kevin
AU - Callahan, John
AU - Fenselau, Catherine
T1 - Extension of microwave-accelerated residue-specific acid cleavage to proteins with carbohydrate side chains and disulfide linkages
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
Y1 - 2008/12//
VL - 278
IS - 2/3
M3 - Article
SP - 109
EP - 113
SN - 13873806
AB - Abstract: This laboratory has introduced a chemical method for residue-specific protein cleavage and has provided a preliminary assessment of the suitability of microwave-accelerated acid cleavage as a proteomic tool. This report is a continuing assessment of the fate of common protein modifications in microwave-accelerated acid cleavage. We have examined the cleavage of ribonuclease A and the related N-linked glycoprotein ribonuclease B, and the O-linked glycoprotein alpha crystallin A chain, using MALDI-TOF and LC–ESI-MS to identify the peptide products. RNase A and B each contains four disulfide bonds, and the addition of a reducing reagent, such as dithiothreitol, was found to be required to achieve efficient acidic proteolysis. The linkage of the glycosidic group to the asparagine side chain in ribonuclease B was found not to be cleaved by brief microwave treatment in 12.5% acetic acid. The distribution of the heterogeneous carbohydrate side chain in the glycopeptide products of acid cleavage was compared to that of the glycopeptide products of tryptic digestion. Hydrolysis within the carbohydrate chain itself is minimal under the conditions used. The O-linked side chain on alpha crystalline A was found to be cleaved during acid cleavage of the protein. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Mass Spectrometry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - PEPTIDES
KW - ORGANIC compounds
KW - GLYCOPEPTIDES
KW - Chemical proteolysis
KW - Disulfide linkages
KW - Glycoprotein
KW - Heterogeneity
N1 - Accession Number: 34920744; Li, Jinxi 1 Shefcheck, Kevin 2 Callahan, John 2 Fenselau, Catherine 1; Email Address: fenselau@umd.edu; Affiliation: 1: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD20742, United States 2: Center for Food Safety and Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD20740, United States; Source Info: Dec2008, Vol. 278 Issue 2/3, p109; Subject Term: PROTEOMICS; Subject Term: PEPTIDES; Subject Term: ORGANIC compounds; Subject Term: GLYCOPEPTIDES; Author-Supplied Keyword: Chemical proteolysis; Author-Supplied Keyword: Disulfide linkages; Author-Supplied Keyword: Glycoprotein; Author-Supplied Keyword: Heterogeneity; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijms.2008.04.030
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Zuocheng
AU - Hopke, Philip K.
AU - Ahmadi, Goodarz
AU - Cheng, Yung-Sung
AU - Baron, Paul A.
T1 - Fibrous particle deposition in human nasal passage: The influence of particle length, flow rate, and geometry of nasal airway
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2008/12//
VL - 39
IS - 12
M3 - Article
SP - 1040
EP - 1054
SN - 00218502
AB - Abstract: Man-made vitreous fibers (MMVFs) have been used as a substitute for asbestos in industrial and residential applications. This shift has raised the concerns of the potential hazards associated with inhalation of these fibers. The human nose is an important protective organ that captures harmful particles and then clears them from human respiratory tract. However, studies have shown that some or even most of the inhalable fibrous particles can penetrate human nose and deposit into the deep lung. The understanding of fibrous particle deposition in the human nasal passage has important occupational health and possible drug delivery applications. To study the deposition pattern and influential factors, three realistic human nasal models were used and a dielectrophoretic classifier was applied to generate test aerosol of glass fibers with a narrow length distribution. These models were made by using stereolithography based on MRI data from two human subjects. Regional and total deposition efficiencies were measured for five different flow rates: 4, 8, 12, 15, and 18Lpm and four different fiber length ranges: 10–19, 20–29, 30–39, and 40–. This study found that deposition of glass fibers (with about diameter) in human nasal passage is mainly due to inertial impaction and these fibers orientated themselves normal to the flow direction before deposition occurs. An effective aerodynamic diameter is defined such that the deposition efficiencies of glass fibers are comparable with those of spherical particles. Non-dimensional parameters were defined and an empirical model based on the experimental results is proposed to calculate fibrous particle deposition efficiency in human nose. Empirical expressions were also developed to estimate the pressure drop across the nasal model. Thus, empirical equations are now available for the prediction of total deposition in the human nasal tract for the fibrous particles under constant inspiring flow rates. In addition, this study suggested that these equations can also be used to predict the deposition of spherical particles. [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIBERS
KW - GLASS fibers
KW - PLANT products
KW - IMAGING systems in medicine
KW - Friction coefficient
KW - Glass fiber
KW - Nasal deposition
KW - Particle deposition efficiency
KW - Pressure drop
KW - Realistic nasal model
KW - Relaxation time
N1 - Accession Number: 35328962; Wang, Zuocheng 1 Hopke, Philip K. 1; Email Address: hopkepk@clarkson.edu Ahmadi, Goodarz 1 Cheng, Yung-Sung 2 Baron, Paul A. 3; Affiliation: 1: Center for Air Resources Engineering and Science, Clarkson University, Potsdam, NY, USA 2: Lovelace Respiratory Research Institute, Albuquerque, NM, USA 3: National Institute for Occupational Safety and Health, Cincinnati, OH, USA; Source Info: Dec2008, Vol. 39 Issue 12, p1040; Subject Term: FIBERS; Subject Term: GLASS fibers; Subject Term: PLANT products; Subject Term: IMAGING systems in medicine; Author-Supplied Keyword: Friction coefficient; Author-Supplied Keyword: Glass fiber; Author-Supplied Keyword: Nasal deposition; Author-Supplied Keyword: Particle deposition efficiency; Author-Supplied Keyword: Pressure drop; Author-Supplied Keyword: Realistic nasal model; Author-Supplied Keyword: Relaxation time; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; NAICS/Industry Codes: 327993 Mineral Wool Manufacturing; NAICS/Industry Codes: 238310 Drywall and Insulation Contractors; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 326193 Motor vehicle plastic parts manufacturing; NAICS/Industry Codes: 327212 Other Pressed and Blown Glass and Glassware Manufacturing; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.jaerosci.2008.07.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Haverkos, Harry W.
T1 - Multifactorial etiology of Kaposi's sarcoma: a hypothesis.
JO - Journal of Biosciences
JF - Journal of Biosciences
Y1 - 2008/12//
VL - 33
IS - 5
M3 - Article
SP - 643
EP - 651
PB - Springer Science & Business Media B.V.
SN - 02505991
AB - Kaposi's sarcoma (KS) is the most common cancer among AIDS patients in North America and Europe, and also occurs among elderly Mediterranean men, sub-Saharan African adults and children, and organ transplant recipients. In 1994 Chang et al identified a new herpes virus, HHV-8, as the cause of KS. However, the abrupt onset followed by a steep decline in AIDS-associated KS in the USA suggests HHV-8 is insufficient to induce KS and that additional factors are required. Immunosuppression via HIV, malnutrition, and chemotherapy appears to play a role. In addition, vasoactive agents have been linked to KS in epidemiologic studies and anecdotal reports. Ziegler et al suggest that aluminosilicates from African volcanic soils activate HHV-8 to induce KS. Dermatologists have reported a few patients developing KS after initiating captopril or lisinopril therapy and regression of lesions when therapy discontinued. Several epidemiologic studies, but not all, have demonstrated significant associations between development of AIDS-related KS and use of large quantities on nitrite inhalants; furthermore, nitrites are mutagenic. It may be that KS results from a complex interaction between HHV-8, immunosuppression, and vasoactive agents. More research is needed to evaluate these hypotheses to elucidate the cause(s) of KS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biosciences is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KAPOSI'S sarcoma
KW - AIDS patients
KW - TRANSPLANTATION of organs, tissues, etc.
KW - HERPESVIRUS diseases
KW - IMMUNOSUPPRESSION
KW - MALNUTRITION
KW - UNITED States
KW - Aluminosilicates
KW - co-carcinogenesis
KW - human herpesvirus-8
KW - human immunodefi ciency virus
KW - Kaposi's sarcoma
KW - nitrite inhalants
N1 - Accession Number: 36850851; Haverkos, Harry W. 1; Email Address: hhaverkos@usuhs.mil; Affiliation: 1: Captain US Public Health Service Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA; Source Info: Dec2008, Vol. 33 Issue 5, p643; Subject Term: KAPOSI'S sarcoma; Subject Term: AIDS patients; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: HERPESVIRUS diseases; Subject Term: IMMUNOSUPPRESSION; Subject Term: MALNUTRITION; Subject Term: UNITED States; Author-Supplied Keyword: Aluminosilicates; Author-Supplied Keyword: co-carcinogenesis; Author-Supplied Keyword: human herpesvirus-8; Author-Supplied Keyword: human immunodefi ciency virus; Author-Supplied Keyword: Kaposi's sarcoma; Author-Supplied Keyword: nitrite inhalants; Number of Pages: 9p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chorng-Ming Cheng
AU - Wen Lin
AU - Khanh Thien Van
AU - Lieuchi Phan
AU - Tran, Nelly N.
AU - Farmer, Doris
T1 - Rapid Detection of Salmonella in Foods Using Real-Time PCR. .
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2008/12//
VL - 71
IS - 12
M3 - Article
SP - 2436
EP - 2441
SN - 0362028X
AB - Conventional methods for detection of Salmonella serovars in foods are generally time-consuming and labor intensive. A real-time PCR method has been developed with custom designed primers and a TaqMan probe to detect the presence of a 262-bp fragment of the Salmonella-specific invA gene. The method has been tested with a total of 384 field-isolated Salmonella serovars and non-Salmonella stock strains, as well as 420 U.S. Food and Drug Administration food samples, comprising a variety of food matrices. The method was highly specific in detecting Salmonella in spiked chili powder and shrimp samples, with a sensitivity of 0.04 CFU/g. In addition, the method is faster, more accurate, and less costly than the traditional U.S. Food and Drug Administration's Bacteriological Analytical Manual cell-culturing and the AOAC International-approved VIDAS methods to detect Salmonella in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Enterobacteriaceae
KW - Food pathogens
KW - Polymerase chain reaction
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 35792961; Chorng-Ming Cheng 1; Email Address: chorng-ming.cheng@fda.hhs.gov; Wen Lin 1; Khanh Thien Van 1; Lieuchi Phan 1; Tran, Nelly N. 1; Farmer, Doris 2; Affiliations: 1: U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Irvine, California 92612; 2: U.S. Food and Drug Administration, Denver District Laboratory, Denver, Colorado 80225, USA; Issue Info: Dec2008, Vol. 71 Issue 12, p2436; Thesaurus Term: Salmonella; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Food pathogens; Subject Term: Polymerase chain reaction; Subject: United States ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 6p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thomas, Laurine
AU - Clarke, Thomas
AU - Kroliczak, Alice
T1 - Implementation of Peer Support Demonstration Project for HIV+ Caribbean Immigrants: A Descriptive Paper.
JO - Journal of Immigrant & Refugee Studies
JF - Journal of Immigrant & Refugee Studies
Y1 - 2008/12//
VL - 6
IS - 4
M3 - Article
SP - 526
EP - 544
SN - 15562948
AB - The purpose of this paper is to describe the Caribbean HIV Evaluation Support demonstration program, a five-site HRSA-funded demonstration project that aimed to implement a peer support intervention to help HIV-positive Caribbeans living in the United States. This paper provides a framework of the demonstration including the rationale for the program, program requirements, and eligibility of participants. In addition, this paper describes each of the five programs including, Brookdale University Hospital and Medical Center, Brooklyn, NY; Lutheran Medical Center, Brooklyn, NY; Community Healthcare Network, New York, NY; University of Miami, Miami, FL; and Montefiore Medical Center, Bronx, NY. The background of each program description includes: setting, theoretical frameworks, peer training, client recruitment & staffing and content of the intervention. Finally, lessons learned including the utility and feasibility of the peer-support intervention program is identified at the closing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immigrant & Refugee Studies is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMIGRANTS -- Services for
KW - HIV-positive persons
KW - PEERS
KW - MEDICAL care
KW - UNITED States
KW - Caribbean immigrants
KW - healthcare
KW - HIV/AIDS
KW - interventions
KW - peer-support demonstration
KW - UNITED States. Health Resources & Services Administration
N1 - Accession Number: 36261457; Thomas, Laurine 1 Clarke, Thomas 2; Email Address: tclarke@aed.org Kroliczak, Alice 3; Affiliation: 1: Project Director, Center for Applied and Behavioral Evaluation Research, Academy for Educational Development, Washington, DC 2: Program Associate, Center for Applied and Behavioral Evaluation Research, Academy for Educational Development, Washington, DC 3: Project Officer, United States Department of Health and Human Services, Health Resources and Services Administration (HRSA), HIV Special Projects of National Significance, Rockville, MD; Source Info: 2008, Vol. 6 Issue 4, p526; Subject Term: IMMIGRANTS -- Services for; Subject Term: HIV-positive persons; Subject Term: PEERS; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: Caribbean immigrants; Author-Supplied Keyword: healthcare; Author-Supplied Keyword: HIV/AIDS; Author-Supplied Keyword: interventions; Author-Supplied Keyword: peer-support demonstration; Company/Entity: UNITED States. Health Resources & Services Administration; NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 19p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/15362940802480407
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Feibus, Karen B.
T1 - FDA's Proposed Rule for Pregnancy and Lactation Labeling: Improving Maternal Child Health Through Well-informed Medicine Use.
JO - Journal of Medical Toxicology
JF - Journal of Medical Toxicology
Y1 - 2008/12//
VL - 4
IS - 4
M3 - Article
SP - 284
EP - 288
SN - 15569039
AB - For the US Food and Drug Administration (FDA), the May 29, 2008 publication of the Proposed Rule for Pregnancy and Lactation Labeling for Human Prescription Drug and Biological Products heralded both an end and a beginning. It marked an end to the labeling initiative process that produced the Proposed Rule and the beginning of FDA's second-generation approach to labeling drugs and biologics for use during pregnancy, breastfeeding, and the childbearing years. These proposed changes reflect the extensive input and feedback FDA collected from clinicians and experts, and are designed to facilitate informed counseling about and prescribing of medicines for women who are pregnant, breastfeeding, or of childbearing potential. The prescription drug label is FDA's communication tool--it is the place to clearly convey what is known about the safe and effective use of a drug in various populations. With development and implementation of the Physician Labeling Rule (PLR), FDA transformed the prescription drug label into a better communication tool in which information is better organized, clearly presented, and more easily located. The Proposed Rule for Pregnancy and Lactation Labeling is the final piece of PLR, creating a detailed and defined framework in which to present what is and is not known about the use of drugs during pregnancy and breastfeeding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Medical Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS
KW - BIOLOGICALS
KW - GOVERNMENT policy
KW - PREGNANCY
KW - BREASTFEEDING (Humans)
KW - LABELING
KW - UNITED States
KW - FDA
KW - labeling
KW - lactation
KW - Pregnancy
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 35187775; Feibus, Karen B. 1; Email Address: karen.feibus@fda.hhs.gov; Affiliation: 1: Medical Team Leader, Maternal Health Team, Pediatric and Maternal Health Staff, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration; Source Info: Dec2008, Vol. 4 Issue 4, p284; Subject Term: DRUGS; Subject Term: BIOLOGICALS; Subject Term: GOVERNMENT policy; Subject Term: PREGNANCY; Subject Term: BREASTFEEDING (Humans); Subject Term: LABELING; Subject Term: UNITED States; Author-Supplied Keyword: FDA; Author-Supplied Keyword: labeling; Author-Supplied Keyword: lactation; Author-Supplied Keyword: Pregnancy; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harper, Martin
AU - Lee, Eun Gyung
AU - Doorn, Stacy S.
AU - Hammond, Okisha
T1 - Differentiating Non-Asbestiform Amphibole and Amphibole Asbestos by Size Characteristics.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/12//
VL - 5
IS - 12
M3 - Article
SP - 761
EP - 770
PB - Taylor & Francis Ltd
SN - 15459624
AB - Mining or processing asbestos minerals can liberate isolated fibers or fiber bundles regulated as airborne asbestos fibers. Coarsely crystalline amphibole minerals are more common than asbestos in many geologic environments, and disturbance can result in the release of prismatic or acicular single crystals or cleavage fragments resembling asbestos fibers or fiber bundles but that are not currently regulated as asbestos. Bulk samples of six coarsely crystalline amphiboles and their five asbestos analogs were processed to maximize the number of particles meeting the criterion for counting under the current U.S. National Institute for Occupational Safety and Health Method 7400 'A' counting rules (> 5 μm long with an aspect ratio ≥ 3:1) and also within the respirable width range, i.e. < 3 μm width. The length distributions of the particles produced showed substantial overlap between cleavage fragments and asbestos fibers. Available data sets generally confirmed the relevance of the size distributions of particles generated from reference materials to airborne particles. The length criterion in the current ASTM International standard D7200-06 causes a large proportion (e.g., 40% grunerite and 39% tremolite) of the non-asbestiform particles to be considered potential asbestos. An alternative procedure may be to use a distinction based on width alone as some, but not the majority of, cleavage fragments were thinner than 1 μm (e.g., 9% of actinolite and 20% of grunerite particles), and not many amphibole asbestos particles were wider (e.g., 5% of crocidolite and 18% of amosite particles). This proposal would need further testing. This research should not be considered as addressing any controversy with regard to the toxicity of non-asbestiform amphibole particles of similar dimensions to asbestos particles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mines & mineral resources
KW - Asbestos
KW - Hazardous wastes
KW - Industrial safety
KW - Amphiboles
KW - asbestos
KW - cleavage fragments
KW - mineral fibers
KW - mining
N1 - Accession Number: 75127839; Harper, Martin 1; Lee, Eun Gyung 1; Doorn, Stacy S. 2; Hammond, Okisha 2; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Microanalytical Sciences Department, RTI International, Research Triangle Park, North Carolina; Issue Info: Dec2008, Vol. 5 Issue 12, p761; Thesaurus Term: Mines & mineral resources; Thesaurus Term: Asbestos; Thesaurus Term: Hazardous wastes; Thesaurus Term: Industrial safety; Subject Term: Amphiboles; Author-Supplied Keyword: asbestos; Author-Supplied Keyword: cleavage fragments; Author-Supplied Keyword: mineral fibers; Author-Supplied Keyword: mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 10p; Document Type: Article
L3 - 10.1080/15459620802462290
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gold, Laura S.
AU - De Roos, Anneclaire J.
AU - Waters, Martha
AU - Stewart, Patricia
T1 - Systematic Literature Review of Uses and Levels of Occupational Exposure to Tetrachloroethylene.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2008/12//
VL - 5
IS - 12
M3 - Article
SP - 807
EP - 839
PB - Taylor & Francis Ltd
SN - 15459624
AB - Tetrachloroethylene has been one of the most widely used chlorinated solvents in the United States. This review provides a basis for tetrachloroethylene exposure assessment in population-based case-control studies. We performed literature searches in MEDLINE, TOXLINE, NIOSHTIC, and the NIOSH Health Hazard Evaluation databases using relevant search terms. We calculated weighted arithmetic means from the measurement data and compiled these into three summary tables by type of operation: (1) dry cleaning, (2) degreasing, and (3) other operations. We identified 258 relevant documents, of which 179 (69%) contained useful descriptive information. Within the dry cleaning industry, the overall arithmetic mean (AM) for personal tetrachloroethylene exposures was 59 ppm (range: 0-4636, n = 1395). Machine operators who transferred wet garments to a dryer had the highest levels (AM = 150 ppm [range: 0-1000, n = 441]) of the jobs in this industry. The AM for personal measurements associated with degreasing was 95 ppm (range: 0-1800, n = 206). In addition, we identified several other sources of substantial tetrachloroethylene exposure, including cleaning mining equipment, testing coal, cleaning animal coats in taxidermy, and cleaning and duplicating film. Exposure assessment in population-based, case-control studies is a complex process requiring substantial resources. Researchers conducting these types of studies will be able to use results of the measurements to quantify tetrachloroethylene exposure levels for various jobs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tetrachloroethylene
KW - Chlorohydrocarbons
KW - Occupational hazards
KW - Dry cleaning
KW - United States
KW - case control study
KW - chlorinated solvents
KW - degreasing
KW - dry cleaning
KW - exposure assessment
N1 - Accession Number: 75127834; Gold, Laura S. 1; De Roos, Anneclaire J. 1; Waters, Martha 2; Stewart, Patricia 3; Affiliations: 1: Department of Epidemiology, University of Washington, Seattle, Washington,Fred Hutchinson Cancer Research Center, Seattle, Washington; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Stewart Exposure Assessments, LLC, Arlington, Virginia; Issue Info: Dec2008, Vol. 5 Issue 12, p807; Thesaurus Term: Tetrachloroethylene; Thesaurus Term: Chlorohydrocarbons; Thesaurus Term: Occupational hazards; Subject Term: Dry cleaning; Subject: United States; Author-Supplied Keyword: case control study; Author-Supplied Keyword: chlorinated solvents; Author-Supplied Keyword: degreasing; Author-Supplied Keyword: dry cleaning; Author-Supplied Keyword: exposure assessment; NAICS/Industry Codes: 812310 Coin-Operated Laundries and Drycleaners; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 33p; Document Type: Article
L3 - 10.1080/15459620802510866
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127834&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105625606
T1 - Differentiating non-asbestiform amphibole and amphibole asbestos by size characteristics.
AU - Harper M
AU - Lee EG
AU - Doorn SS
AU - Hammond O
Y1 - 2008/12//
N1 - Accession Number: 105625606. Language: English. Entry Date: 20090130. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants, Occupational -- Analysis
KW - Asbestos -- Analysis
KW - Occupational Exposure -- Analysis
KW - Particulate Matter -- Analysis
KW - Environmental Monitoring -- Methods
KW - Particle Size
KW - United States
KW - United States Occupational Safety and Health Administration
KW - Human
SP - 761
EP - 770
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 5
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Mining or processing asbestos minerals can liberate isolated fibers or fiber bundles regulated as airborne asbestos fibers. Coarsely crystalline amphibole minerals are more common than asbestos in many geologic environments, and disturbance can result in the release of prismatic or acicular single crystals or cleavage fragments resembling asbestos fibers or fiber bundles but that are not currently regulated as asbestos. Bulk samples of six coarsely crystalline amphiboles and their five asbestos analogs were processed to maximize the number of particles meeting the criterion for counting under the current U.S. National Institute for Occupational Safety and Health Method 7400 'A' counting rules (>5 [micro]m long with an aspect ratio >/=3:1) and also within the respirable width range, i.e. <3 [micro]m width. The length distributions of the particles produced showed substantial overlap between cleavage fragments and asbestos fibers. Available data sets generally confirmed the relevance of the size distributions of particles generated from reference materials to airborne particles. The length criterion in the current ASTM International standard D7200-06 causes a large proportion (e.g., 40% grunerite and 39% tremolite) of the non-asbestiform particles to be considered potential asbestos. An alternative procedure may be to use a distinction based on width alone as some, but not the majority of, cleavage fragments were thinner than 1 [micro]m (e.g., 9% of actinolite and 20% of grunerite particles), and not many amphibole asbestos particles were wider (e.g., 5% of crocidolite and 18% of amosite particles). This proposal would need further testing. This research should not be considered as addressing any controversy with regard to the toxicity of non-asbestiform amphibole particles of similar dimensions to asbestos particles.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Exposure Assessment Branch, Health Effects Laboratory Division, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505; zzg7@cdc.gov
U2 - PMID: 18828048.
DO - 10.1080/15459620802462290
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Alterman, Toni
AU - Grosch, James
AU - Xiao Chen
AU - Chrislip, David
AU - Petersen, Martin
AU - Krieg Jr., Edward
AU - Haejoo Chung
AU - Muntaner, Carles
T1 - Examining Associations Between Job Characteristics and Health: Linking Data From the Occupational Information Network (O*NET) to Two U.S. National Health Surveys.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2008/12//
VL - 50
IS - 12
M3 - Article
SP - 1401
EP - 1413
SN - 10762752
AB - The article presents a study which examines the association between job characteristics and health from the data obtained from the Occupational Information Network (O*NET) and two U.S. National Health surveys. It mentions that the study aims to determine whether the O*NET database identifies the job dimensions to serve as proxy measures for psychological factors and to determine whether the factors could be linked to national health surveys. The job characteristics are obtained from O*NET 98 while the health outcomes were obtained from two national surveys. The study found out that seven of nine work organization are significantly associated with health risk behaviors in the National Health and Nutrition Examination Survey III and National Health Interview Survey.
KW - Industrial hygiene
KW - Environmental engineering
KW - Health surveys
KW - Work structure
KW - Work environment
KW - Psychosocial factors
KW - Job descriptions
KW - Data
KW - United States
N1 - Accession Number: 35933619; Alterman, Toni 1; Email Address: talterman@cdc.gov; Grosch, James 2; Xiao Chen 1; Chrislip, David 2; Petersen, Martin 1; Krieg Jr., Edward 2; Haejoo Chung 3; Muntaner, Carles 3; Affiliations: 1: Division of Surveillance, Hazard Evaluations and Field Studies,, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA; 3: Center for Addiction and Mental Health, University of Toronto, Toronto, Canada; Issue Info: Dec2008, Vol. 50 Issue 12, p1401; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental engineering; Subject Term: Health surveys; Subject Term: Work structure; Subject Term: Work environment; Subject Term: Psychosocial factors; Subject Term: Job descriptions; Subject Term: Data; Subject: United States; Number of Pages: 13p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
L3 - 10.1097/JOM.0b013e318188e882
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105610739
T1 - Cumulative sensitization and disease in a beryllium oxide ceramics worker cohort.
AU - Schuler CR
AU - Kitt MM
AU - Henneberger PK
AU - Deubner DC
AU - Kreiss K
Y1 - 2008/12//
N1 - Accession Number: 105610739. Language: English. Entry Date: 20090227. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: American Red Cross September 11 Recovery Program, Bear Stearns Charitable Foundation, September 11 Fund, Robin Hood Foundation. NLM UID: 9504688.
KW - Beryllium -- Adverse Effects
KW - Industry
KW - Lung Diseases -- Etiology
KW - Lung Diseases -- Risk Factors
KW - Occupational Exposure
KW - Chi Square Test
KW - Confidence Intervals
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Education, Continuing (Credit)
KW - Fisher's Exact Test
KW - Funding Source
KW - Kruskal-Wallis Test
KW - P-Value
KW - Questionnaires
KW - Survey Research
KW - Wilcoxon Rank Sum Test
KW - Human
SP - 1343
EP - 1350
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 50
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD).Methods: We invited the cohort's participation in current worker surveys in 1992, 1998, 2000, and 2002-2003, and in former worker surveys in 2000-2001 and 2003. We calculated 11-year cumulative incidences (after 1992 initial survey) of sensitization and CBD, both crude and corrected for interval censoring; and period prevalences (including 1992 findings), crude and corrected.Results: In 1992, point prevalences were 6% sensitized and 4% CBD. We obtained follow-up on 83% of 128 not sensitized in 1992. Crude cumulative incidences for sensitization and CBD were 13% and 9%, respectively; corrected were 15% and 11%. Crude period prevalences for sensitization and CBD were 16% and 11%, respectively; corrected were 20% and 14%. Corrected period prevalences for pre-1992 machining work were 30% and 20%.Conclusions: With repeated testing over 11 years, total sensitization and CBD in this cohort were triple initial 1992 survey results.
SN - 1076-2752
AD - Division of Respiratory Disease Studies, Field Studies Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505; christine.schuler@cdc.hhs.gov
U2 - PMID: 19092488.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109850238
T1 - Medicare policy marks new link between hospital payment, patient safety.
AU - Clancy CM
Y1 - 2008/12//2008 Dec
N1 - Accession Number: 109850238. Language: English. Entry Date: 20090220. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Patient Safety. NLM UID: 101233393.
KW - Hospitals -- Economics
KW - Medicare -- Administration
KW - Reimbursement Mechanisms
KW - Treatment Errors -- Prevention and Control
KW - Accountability
KW - Catheter-Related Infections
KW - Cross Infection
KW - Insurance Carriers
KW - Intraoperative Complications
KW - Pressure Ulcer
KW - Professional Practice, Evidence-Based
KW - Retained Instruments
SP - 215
EP - 216
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 4
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850; joyce.middleton@ ahrq.hhs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hamad, Mazen L.
AU - Gupta, Abhay
AU - Shah, Rakhi B.
AU - Lyon, Robbe C.
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
T1 - Functionality of magnesium stearate derived from bovine and vegetable sources: Dry granulated tablets.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2008/12//
VL - 97
IS - 12
M3 - Article
SP - 5328
EP - 5340
SN - 00223549
AB - Magnesium stearate is a functional excipient used to ensure efficient ejection of tablets. This study compares the functionality of a vegetable and bovine grade of magnesium stearate. Tablets were prepared by direct compression and dry granulation of a model formulation. Physical and chemical tests were performed on bulk powders, granule intermediates, and finished tablets to provide a comprehensive comparison of the two grades of magnesium stearates. Raw material characterization of the two grades showed no difference in particle size, surface area, true density, and total moisture content. However, significant differences in fatty acid composition, surface tension, and zeta potential were detected. Tablet ejection force for the physical mixture formulations was variable, showing similar ejection force for the two grades of magnesium stearate at some concentrations and different ejection forces at other concentrations. The dry granulated formulation containing vegetable-based magnesium stearate showed a lower ejection force than the formulation containing bovine-based magnesium stearate. There was no difference between the dissolution profiles of the tablets containing the two grades of magnesium stearate prepared by both methods. The results indicated that magnesium stearate interchangeability with respect to lubricant efficiency depends upon the level in which it is used and the manufacturing method. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:5328–5340, 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TABLETS (Medicine)
KW - MAGNESIUM compounds
KW - DRUGS -- Granulation
KW - MOISTURE
KW - DENSITY
KW - characterization
KW - functionality
KW - lubricant efficiency
KW - physical mixture
KW - slugging
N1 - Accession Number: 35075754; Hamad, Mazen L. 1 Gupta, Abhay 1 Shah, Rakhi B. 1 Lyon, Robbe C. 1 Sayeed, Vilayat A. 2 Khan, Mansoor A. 1; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, Life Science Building 64, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993 2: Division of Chemistry III, Office of Generic Drugs, Food and Drug Administration, 7500 Standish Place, Rockville, Maryland 20855; Source Info: Dec2008, Vol. 97 Issue 12, p5328; Subject Term: TABLETS (Medicine); Subject Term: MAGNESIUM compounds; Subject Term: DRUGS -- Granulation; Subject Term: MOISTURE; Subject Term: DENSITY; Author-Supplied Keyword: characterization; Author-Supplied Keyword: functionality; Author-Supplied Keyword: lubricant efficiency; Author-Supplied Keyword: physical mixture; Author-Supplied Keyword: slugging; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 13p; Illustrations: 4 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BENNETT, REGINALD W.
T1 - AN ANTIBODY MODIFIED AUTOMATED ENZYME-LINKED IMMUNOSORBENT ASSAY-BASED METHOD FOR DETECTION OF STAPHYLOCOCCAL ENTEROTOXIN.
JO - Journal of Rapid Methods & Automation in Microbiology
JF - Journal of Rapid Methods & Automation in Microbiology
Y1 - 2008/12//
VL - 16
IS - 4
M3 - Article
SP - 320
EP - 329
SN - 10603999
AB - Studies were conducted with an automated enzyme-linked immunosorbent assay (ELISA)-based method (Vidas, Staph enterotoxin-II [SET-II]), exhibiting an antibody capture that had undergone modification by removal of the Fc fragment on the antibody. Raw liquid or shell eggs containing a nontoxin component with an attraction to the staphylococcal antienterotoxins were studied. Prior to ELISA testing, the eggs were homogenized and extracts collected by centrifugation. Studies showed that regardless of the ELISA-based method used that utilized the unmodified antibodies with both the Fab1 + Fc fragments intact, positive (false positive) ELISA responses occurred with fertilized egg yolks and fertilized whole liquid or whole shell eggs. Conversely, when modified (Fab1) antibodies were used, the automated SET-II enzyme-linked fluorescent immunoassay was negative. PRACTICAL APPLICATIONS Most enzyme-linked immunosorbent assays as well as other serological systems use the whole antibody that has not undergone modification for the detection of the staphylococcal enterotoxins. The use of whole antibody (Fab1 + Fc fragments) has on occasion produced false positive results. However, the antibody in which the Fc fragment has been removed leaving the Fab1 fragment provides a more specific antibody for the identification of this microbial toxin. The use of modified antibody (Fab1 fragment) represents significant improvement in antibody quality thus ensuring a greater degree of specificity without sacrificing the sensitivity of serological methods for the detection of staphylococcal enterotoxin in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Rapid Methods & Automation in Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - ENZYME-linked immunosorbent assay
KW - ENTEROTOXINS
KW - SEROLOGY
KW - EGG yolk
KW - FOOD contamination
N1 - Accession Number: 35524159; BENNETT, REGINALD W. 1; Email Address: reginald.bennett@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835; Source Info: Dec2008, Vol. 16 Issue 4, p320; Subject Term: IMMUNOGLOBULINS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: ENTEROTOXINS; Subject Term: SEROLOGY; Subject Term: EGG yolk; Subject Term: FOOD contamination; Number of Pages: 10p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
L3 - 10.1111/j.1745-4581.2008.00138.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35524159&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DONGYOU LIU
AU - LAWRENCE, MARK L.
AU - HITCHINS, ANTHONY D.
T1 - MOLECULAR CHARACTERIZATION OF LISTERIA MONOCYTOGENES STRAINS HARBORING LISTERIA INNOCUA PUTATIVE TRANSCRIPTIONAL REGULATOR GENE LIN0464.
JO - Journal of Rapid Methods & Automation in Microbiology
JF - Journal of Rapid Methods & Automation in Microbiology
Y1 - 2008/12//
VL - 16
IS - 4
M3 - Article
SP - 412
EP - 427
SN - 10603999
AB - The genus Listeria comprises six closely related bacterial species that share considerable morphological, ecological, biochemical and molecular similarities. In this study, through examination of a large collection (n = 84) of Listeria monocytogenes strains, we identified four serovar 4c strains (i.e., RM3894, RM3899, RM3901 and RM3905) that cross-reacted with Listeria innocua putative transcriptional regulator gene lin0464 primers. We then investigated these four unusual strains by polymerase chain reaction (PCR) with primers for several L. monocytogenes species-, virulence- and group-specific genes and a newly identified L. innocua- specific transcriptional regulator lin2455 gene. The fact that the four strains were recognized by L. monocytogenes inlA, lmo0733, inlJ, lmo2672 and lmo1134 primers but undetected by L. innocua- specific lin2455 primers suggests their L. monocytogenes species identity, and this was confirmed by their testing positive for the presence of L. monocytogenes specific rRNA. As these strains displayed a reaction pattern with L. monocytogenes- specific primers that is typical of lineage subgroup IIIA serovar 4c strains (ATCC 19116, RM3030 and FSL-F2-458), they are likely of serovar 4c in the lineage subgroup IIIA in spite of their possession of L. innocua putative transcriptional regulator gene lin0464. It is clear from this and other published examples that the close relatedness of the Listeria species even extends to the occasional possession by one species of gene(s) normally regarded as specific to another species. PRACTICAL APPLICATIONS Given that Listeria species resemble each other closely and often coexist in clinical, food and environmental specimens, it is important to develop a capability to differentiate pathogenic Listeria monocytogenes from nonpathogenic Listeria species, such as Listeria innocua. By employing primers derived from a newly identified L. innocua-specific gene lin2455, along with several L. monocytogenes primers, it is possible to confirm the species and subgroup identity of L. monocytogenes strains (RM3894, RM3899, RM3901 and RM3905) possessing L. innocua putative transcriptional regulator lin0464 gene. From a food safety perspective, the ability to rapidly and precisely determine Listeria food isolates as L. innocua species with polymerase chain reaction targeting lin2455 gene offers a valuable means to verify the nonpathogenic nature of the bacteria present. On the other hand, the benefit of utilizing molecular techniques to distinguish between avirulent serovar 4a and potentially virulent serovar 4c, as well as non4a-non4c (including 7) within lineage III lies in that it will generate additional caution and preparedness among laboratory and hospital personnel in their handling of lineage III isolates that may be potentially pathogenic. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Rapid Methods & Automation in Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LISTERIA monocytogenes
KW - POLYMERASE chain reaction
KW - FOOD -- Safety measures
KW - BACTERIA -- Morphology
KW - PATHOGENIC bacteria
KW - GENETICS
N1 - Accession Number: 35524152; DONGYOU LIU 1; Email Address: liu@cvm.msstate.edu LAWRENCE, MARK L. 1 HITCHINS, ANTHONY D. 2; Affiliation: 1: College of Veterinary Medicine, Mississippi State University, PO Box 6100, MS 39762 2: Food and Drug Administration, College Park, MD; Source Info: Dec2008, Vol. 16 Issue 4, p412; Subject Term: LISTERIA monocytogenes; Subject Term: POLYMERASE chain reaction; Subject Term: FOOD -- Safety measures; Subject Term: BACTERIA -- Morphology; Subject Term: PATHOGENIC bacteria; Subject Term: GENETICS; Number of Pages: 16p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1111/j.1745-4581.2008.00145.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - Ultrasonic attenuation in parallel-nylon-wire cancellous-bone-mimicking phantoms.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2008/12//
VL - 124
IS - 6
M3 - Article
SP - 4042
EP - 4046
SN - 00014966
AB - Attenuation coefficients between 1.5 and 3.5 MHz were measured on four parallel-nylon-wire arrays (simulating cancellous bone) with four different wire diameters (150, 200, 250, and 300 μm). Interwire spacing was 800 μm for all four parallel-nylon-wire arrays. The measured frequency dependencies of attenuation were consistent with theoretical predications based on Faran’s theory, which considers the component of attenuation due to scattering of longitudinal waves. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRASONIC waves -- Attenuation
KW - SCATTERING (Physics)
KW - AUDIO frequency
KW - ATTENUATION (Physics)
KW - SOUND waves
KW - WAVES (Physics)
N1 - Accession Number: 36425929; Wear, Keith A. 1; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993; Source Info: Dec2008, Vol. 124 Issue 6, p4042; Subject Term: ULTRASONIC waves -- Attenuation; Subject Term: SCATTERING (Physics); Subject Term: AUDIO frequency; Subject Term: ATTENUATION (Physics); Subject Term: SOUND waves; Subject Term: WAVES (Physics); Number of Pages: 5p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1121/1.2998784
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHU, Haitao
AU - NIE, Lei
T1 - A Few Remarks on "A Capture--Recapture Approach for Screening Using Two Diagnostic Tests With Availability of Disease Status for the Test Positives Only" by Böhning and Patilea.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2008/12//
VL - 103
IS - 484
M3 - Article
SP - 1518
EP - 1519
SN - 01621459
AB - The article presents a response to a previously published article by D. Böhning and V. Patilea on diagnostic testing. In the original article, the authors argued for a capture-recapture screening approach, which offered availability of disease status only for positive tests. Details are provided about unobserved cell counting and the use of maximum likelihood estimators (MLEs) in the original article. Several different mathematical models are presented in an attempt to illustrate closed-form MLEs.
KW - MATHEMATICAL models
KW - ESTIMATION theory
KW - MATHEMATICAL statistics
KW - STATISTICS
KW - RESEARCH
KW - DIAGNOSIS
KW - MEDICAL statistics
KW - MAXIMUM likelihood statistics
KW - FUNCTIONS (Mathematics)
KW - EQUATIONS
KW - PARAMETERS (Statistics)
KW - BOEHNING, D.
KW - PATILEA, V.
N1 - Accession Number: 36575726; CHU, Haitao 1; Email Address: hchu@bios.unc.edu; NIE, Lei 2; Email Address: lie.nie@fda.hhs.gov; Affiliations: 1: Research Associate Professor, Department of Biostatistics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27516; 2: Mathematical Statistician, Office of Biostatistics, Food and Drug Administration, Silver Spring, MD 20993; Issue Info: Dec2008, Vol. 103 Issue 484, p1518; Thesaurus Term: MATHEMATICAL models; Thesaurus Term: ESTIMATION theory; Thesaurus Term: MATHEMATICAL statistics; Thesaurus Term: STATISTICS; Thesaurus Term: RESEARCH; Subject Term: DIAGNOSIS; Subject Term: MEDICAL statistics; Subject Term: MAXIMUM likelihood statistics; Subject Term: FUNCTIONS (Mathematics); Subject Term: EQUATIONS; Subject Term: PARAMETERS (Statistics); People: BOEHNING, D.; People: PATILEA, V.; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Ruts, Liselotte
AU - Rico, Roberto
AU - van Koningsveld, Rinske
AU - Botero, Juan D.
AU - Meulstee, Jan
AU - Gerstenbluth, Izzy
AU - Merkies, Ingemar S. J.
AU - van Doorn, Pieter A.
T1 - Pain accompanies pure motor Guillain-Barré syndrome.
JO - Journal of the Peripheral Nervous System
JF - Journal of the Peripheral Nervous System
Y1 - 2008/12//
VL - 13
IS - 4
M3 - Letter
SP - 305
EP - 306
PB - Wiley-Blackwell
SN - 10859489
AB - A letter to the editor is presented regarding pain diagnosis in Guillain-Barré syndrome.
KW - LETTERS to the editor
KW - GUILLAIN-Barre syndrome
N1 - Accession Number: 36078067; Ruts, Liselotte 1; Email Address: l.ruts@erasmusmc.nl Rico, Roberto 2 van Koningsveld, Rinske 3 Botero, Juan D. 2 Meulstee, Jan 4 Gerstenbluth, Izzy 5 Merkies, Ingemar S. J. 6 van Doorn, Pieter A. 1; Affiliation: 1: Department of Neurology, Erasmus MC, Rotterdam, Netherlands 2: Department of Neurology, Saint Elisabeth Hospital, Willemstad, Curaçao, Netherlands Antilles 3: Department of Neurology, Elkerliek Ziekenhuis, Helmond, Netherlands 4: Department of Neurology, Canisius-Wilhelmina Ziekenhuis, Nijmegen, Netherlands 5: Epidemiology and Research Unit, Medical and Public Health Service (GGD), Willemstad, Curacxao, Netherlands Antilles 6: Department of Neurology, Spaarne Ziekenhuis, Hoofddorp, Netherlands; Source Info: Dec2008, Vol. 13 Issue 4, p305; Subject Term: LETTERS to the editor; Subject Term: GUILLAIN-Barre syndrome; Number of Pages: 2p; Illustrations: 1 Chart; Document Type: Letter
L3 - 10.1111/j.1529-8027.2008.00197.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ju Young Ryu
AU - Ena Lee
AU - Tae Hyung Kim
AU - Young Jun Lee
AU - Jaewon Lee
AU - Byung Mu Lee
AU - Seung Jun Kwack
AU - Ki Kyung Jung
AU - Soon Young Han
AU - Seung Hee Kim
AU - Sam Kacew
AU - Hyung Sik Kim
T1 - Time-Response Effects of Testicular Gene Expression Profiles in Sprague-Dawley Male Rats Treated with Di(n-Butyl) Phthalate.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2008/12//
VL - 71
IS - 23
M3 - Article
SP - 1542
EP - 1549
SN - 15287394
AB - Phthalate esters were reported to damage fetal and postnatal testes of experimental animals, but the molecular mechanisms underlying these effects remain unknown. The time-response effects of di(n-butyl) phthalate (DBP) on the expression patterns of the testicular genes in male Sprague-Dawley rats were examined for different periods of exposure (1, 7, 14, or 28 d). The steroidogenic- or spermatogenic-related gene expression patterns were measured using reverse-transcription polymerase chain reaction (RT-PCR). After 28 d of exposure, the serum concentrations of DBP and monobutyl phthalate (MBP) increased in a dose-dependent manner, and were significantly higher in the DBP-treated rats than in the control rats. Liver weight was increased markedly at 28 d after DBP exposure at 750 mg/kg/d. Testicular weight was reduced significantly after 14 and 28 d of exposure. DBP (750 mg/kg/d) produced a significant increase in scavenger receptor class B1 (SR-B1) and steroidogenic acute regulatory (StAR) mRNA after 14 and 28 d of exposure. The level of cytochrome P-450 (P450) side-chain cleavage (P450scc) mRNA decreased in the group treated with DBP at 750 mg/kg/d at 7 d. After 14 and 28 d of exposure, there was an apparent increase in P450scc mRNA. High doses of DBP significantly increased the Cyp17 mRNA level after 28 d of exposure. At 7 d, a significant decrease in Cyp19 mRNA was observed only in the group exposed to 750 mg/kg/d DBP. In addition, DBP significantly decreased the levels of a spermatid-specific gene (Spag4) and lactate dehydrogenase A (LDHA) mRNA after 7 d of exposure. The levels of androgen receptor (AR), estrogen receptor-alpha (ER-alpha), and retinoid X receptor-gamma (RXR-r) expression decreased significantly in a time- or dose-dependent manner. DBP significantly increased the peroxisome proliferator-activated receptor-gamma (PPAR-r) and phosphorylated extracellular-signal-regulated kinase (p-ERK1/2) levels in the testis. These results suggest that the acute and chronic effects of DBP on the steroidogenic pathways in the testes show mechanistically distinct patterns. Data thus provide some insights into the molecular mechanisms underlying DBP-induced testicular dysgenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHTHALATE esters
KW - GENE expression
KW - SEX hormones
KW - POLYMERASE chain reaction
KW - MESSENGER RNA
KW - ANIMAL experimentation
N1 - Accession Number: 34767524; Ju Young Ryu 1 Ena Lee 1 Tae Hyung Kim 1 Young Jun Lee 1 Jaewon Lee 1 Byung Mu Lee 2 Seung Jun Kwack 3 Ki Kyung Jung 3 Soon Young Han 3 Seung Hee Kim 3 Sam Kacew 4 Hyung Sik Kim 1; Email Address: hkims@pusan.ac.kr; Affiliation: 1: College of Pharmacy, Pusan National University, Busan, South Korea 2: Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea 3: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea 4: Department of Pharmacology, Faculty of Medicine, University of Ottawa, Ontario, Canada; Source Info: Dec2008, Vol. 71 Issue 23, p1542; Subject Term: PHTHALATE esters; Subject Term: GENE expression; Subject Term: SEX hormones; Subject Term: POLYMERASE chain reaction; Subject Term: MESSENGER RNA; Subject Term: ANIMAL experimentation; Number of Pages: 8p; Illustrations: 4 Black and White Photographs, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1080/15287390802391992
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grinev, Andriyan
AU - Daniel, Sylvester
AU - Laassri, Majid
AU - Chumakov, Konstantin
AU - Chizhikov, Vladimir
AU - Rios, Maria
T1 - Microarray-based assay for the detection of genetic variations of structural genes of West Nile virus
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2008/12//
VL - 154
IS - 1/2
M3 - Article
SP - 27
EP - 40
SN - 01660934
AB - Abstract: Adaptation through fixation of spontaneous mutations in the viral genome is considered to be one of the important factors that enable recurrent West Nile virus (WNV) outbreaks in the U.S. Genetic variations can alter viral phenotype and virulence, and degrade the performance of diagnostic and screening assays, vaccines, and potential therapeutic agents. A microarray assay was developed and optimized for the simultaneous detection of any nucleotide mutations in the entire structural region of WNV in order to facilitate public health surveillance of genetic variation of WNV. The DNA microarray consists of 263 oligonucleotide probes overlapping at half of their lengths which have been immobilized on an amine-binding glass slide. The assay was validated using 23 WNV isolates from the 2002–2005 U.S. epidemics. Oligonucleotide-based WNV arrays detected unambiguously all mutations in the structural region of each one of the isolates identified previously by sequencing analysis, serving as a rapid and effective approach for the identification of mutations in the WNV genome. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - WEST Nile virus
KW - EPIDEMICS
KW - VIRAL genetics
KW - VARIATION (Biology)
KW - POLYMERASE chain reaction
KW - UNITED States
KW - Flavivirus
KW - Genetic variability
KW - Microarray technology
KW - Mosquito-borne virus
KW - Mutations
KW - PCR
N1 - Accession Number: 35325046; Grinev, Andriyan 1; Email Address: Andriyan.Grinev@fda.hhs.gov Daniel, Sylvester 1 Laassri, Majid 2 Chumakov, Konstantin 2 Chizhikov, Vladimir 2 Rios, Maria 1; Email Address: Maria.Rios@fda.hhs.gov; Affiliation: 1: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Rockville, MD 20852, USA 2: Laboratory of Methods Development, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA; Source Info: Dec2008, Vol. 154 Issue 1/2, p27; Subject Term: DNA microarrays; Subject Term: WEST Nile virus; Subject Term: EPIDEMICS; Subject Term: VIRAL genetics; Subject Term: VARIATION (Biology); Subject Term: POLYMERASE chain reaction; Subject Term: UNITED States; Author-Supplied Keyword: Flavivirus; Author-Supplied Keyword: Genetic variability; Author-Supplied Keyword: Microarray technology; Author-Supplied Keyword: Mosquito-borne virus; Author-Supplied Keyword: Mutations; Author-Supplied Keyword: PCR; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.jviromet.2008.09.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhili Xu
AU - Jie Tian
AU - Smith, Jeffrey S.
AU - Byrnes, Andrew P.
T1 - Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2008/12//
VL - 82
IS - 23
M3 - Article
SP - 11705
EP - 11713
SN - 0022538X
AB - Kupffer cells (KCs) rapidly remove intravenously injected adenovirus (Ad) vectors from the circulation. A better understanding of the mechanisms involved could suggest strategies to improve Ad gene delivery by suppressing or evading KC uptake. We recently showed that clearance of Ad type 5 vectors by KCs does not involve the interaction of Ad with the well-established Ad receptors, namely, integrins or the coxsackievirus and Ad receptor (J. S. Smith, Z. Xu, J. Tian, S. C. Stevenson, and A. P. Byrnes, Hum. Gene Ther. 19:547-554, 2008). In the current study, we systematically quantified the contributions of various receptors and plasma proteins to the clearance of Ad by KCs. We found that scavenger receptors are a predominant mechanism for the clearance of Ad by KCs. In addition, we found that Ad is opsonized by natural immunoglobulin M antibodies and complement and that these opsonins play a contributory role in the clearance of Ad by KCs. We also examined additional mechanisms that have been postulated to be involved in the clearance of Ad, including the binding of Ad to platelets and vitamin K-dependent coagulation factors, but we found that neither of these were required for the clearance of Ad by KCs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - KUPFFER cells
KW - IMMUNOGLOBULINS
KW - PROTEINS
KW - IMMUNOGLOBULIN M
KW - BLOOD proteins
N1 - Accession Number: 35568308; Zhili Xu 1 Jie Tian 1 Smith, Jeffrey S. 1 Byrnes, Andrew P. 1; Email Address: Andrew.Byrnes@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Dec2008, Vol. 82 Issue 23, p11705; Subject Term: ADENOVIRUSES; Subject Term: KUPFFER cells; Subject Term: IMMUNOGLOBULINS; Subject Term: PROTEINS; Subject Term: IMMUNOGLOBULIN M; Subject Term: BLOOD proteins; Number of Pages: 9p; Document Type: Article
L3 - 10.1128/JVI.01320-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cordeiro, Renato S.
AU - Scarano, Wellerson R.
AU - Campos, Silvana G.P.
AU - Santos, Fernanda C.A.
AU - Vilamaior, Patricia S.L.
AU - Góes, Rejane M.
AU - Taboga, Sebastião R.
T1 - Androgen receptor in the Mongolian gerbil ventral prostate: Evaluation during different phases of postnatal development and following androgen blockage
JO - Micron
JF - Micron
Y1 - 2008/12//
VL - 39
IS - 8
M3 - Article
SP - 1312
EP - 1324
SN - 09684328
AB - Abstract: The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses to hormones under several conditions and the effect of their blockage is due to the fact that the human prostate is the site of a great number of age-related diseases, and the ones with a major medical importance are prostate cancer (CaP) and benign prostatic hyperplasia (BPH), which can both be treated with androgen suppression. Seventy-five male gerbils were divided, randomly, into 3 groups of 25 animals each, where each group corresponded to one phase of postnatal development. In each phase, it was possible to morphologically and stereologically analyze the compartments of prostatic ventral lobe, as well as to immunohistochemically analyze the degree of expression of androgen receptors (ARs) after the androgen blockage therapies. In addition, it was possible to establish the hormonal dosage of serum testosterone levels given the comparative approach of the expression of androgen receptors. There is a pattern of AR distribution in the prostatic ventral lobe throughout postnatal development, in which the younger the animal is the higher, the interaction of circulating androgens that stimulate the AR expression in both the epithelial and stromal compartments. The androgen blockage therapies decreased AR expression in the prostatic compartments, but the androgen reposition after these blockages was not sufficient to recover the glandular structure or stimulate the AR expression up to normal physiological conditions. Both the regulation and distribution of androgen receptors along the gerbil prostatic tissues are complex mechanisms that are likely to be genetically regulated by androgens prenatally or by other factors that are still unknown. This rodent species seems to be a valuable model in the attempt to improve the understanding of the morphophysiological and pathological behavior of this important gland in humans throughout aging and to stimulate new therapeutic ideas to fight prostate cancer. [Copyright &y& Elsevier]
AB - Copyright of Micron is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER -- Study & teaching
KW - THERAPEUTICS
KW - CLINICAL medicine
KW - MEDICINE
KW - MEDICAL care
KW - Androgen receptor
KW - Castration
KW - Testosterone
KW - Ventral prostate
N1 - Accession Number: 34435242; Cordeiro, Renato S. 1,2 Scarano, Wellerson R. 1 Campos, Silvana G.P. 3 Santos, Fernanda C.A. 2,3 Vilamaior, Patricia S.L. 2 Góes, Rejane M. 3 Taboga, Sebastião R. 3; Email Address: taboga@ibilce.unesp.br; Affiliation: 1: Department of Cell Biology, Institute of Biology, Campinas State University (UNICAMP), CP 6109, 13084-971 Campinas, Brazil 2: Rio Preto Universitary Center (UNIRP), Veterinary Medicine and Biological Sciences School, São José do Rio Preto, Brazil 3: São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), Laboratory of Microscopy and Microanalysis, Department of Biology, Rua Cristóvão Colombo, 2265 Jardim Nazareth, 15054-000 São José do Rio Preto, SP, Brazil; Source Info: Dec2008, Vol. 39 Issue 8, p1312; Subject Term: CANCER -- Study & teaching; Subject Term: THERAPEUTICS; Subject Term: CLINICAL medicine; Subject Term: MEDICINE; Subject Term: MEDICAL care; Author-Supplied Keyword: Androgen receptor; Author-Supplied Keyword: Castration; Author-Supplied Keyword: Testosterone; Author-Supplied Keyword: Ventral prostate; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.micron.2008.02.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Dong
AU - Rismanchi, Neggy
AU - Renvoisé, Benoît
AU - Lippincott-Schwartz, Jennifer
AU - Blackstone, Craig
AU - Hurley, James H.
T1 - Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2008/12//
VL - 15
IS - 12
M3 - Article
SP - 1278
EP - 1286
PB - Nature Publishing Group
SN - 15459993
AB - The endosomal sorting complex required for transport (ESCRT) machinery, including ESCRT-III, localizes to the midbody and participates in the membrane-abscission step of cytokinesis. The ESCRT-III protein charged multivesicular body protein 1B (CHMP1B) is required for recruitment of the MIT domain–containing protein spastin, a microtubule-severing enzyme, to the midbody. The 2.5-Å structure of the C-terminal tail of CHMP1B with the MIT domain of spastin reveals a specific, high-affinity complex involving a noncanonical binding site between the first and third helices of the MIT domain. The structural interface is twice as large as that of the MIT domain of the VPS4–CHMP complex, consistent with the high affinity of the interaction. A series of unique hydrogen-bonding interactions and close packing of small side chains discriminate against the other ten human ESCRT-III subunits. Point mutants in the CHMP1B binding site of spastin block recruitment of spastin to the midbody and impair cytokinesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENDOSOMES
KW - CYTOKINESIS
KW - ABSCISSION (Botany)
KW - TUBULINS
KW - HELICES (Algebraic topology)
N1 - Accession Number: 35539850; Yang, Dong 1 Rismanchi, Neggy 2 Renvoisé, Benoît 2 Lippincott-Schwartz, Jennifer 3 Blackstone, Craig 2; Email Address: blackstc@ninds.nih.gov Hurley, James H. 1; Email Address: hurley@helix.nih.gov; Affiliation: 1: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA 2: Cellular Neurology Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA 3: Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA; Source Info: Dec2008, Vol. 15 Issue 12, p1278; Subject Term: ENDOSOMES; Subject Term: CYTOKINESIS; Subject Term: ABSCISSION (Botany); Subject Term: TUBULINS; Subject Term: HELICES (Algebraic topology); Number of Pages: 9p; Illustrations: 5 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/nsmb.1512
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105596373
T1 - Outbreak case reports.
AU - Manuel J
AU - Whitmore J
AU - Baker S
AU - Barnfather D
Y1 - 2008/12//
N1 - Accession Number: 105596373. Language: English. Entry Date: 20090109. Revision Date: 20151015. Publication Type: Journal Article; case study. Journal Subset: Australia & New Zealand; Biomedical; Public Health. Special Interest: Public Health. NLM UID: 101213519.
KW - Disease Outbreaks -- Trends -- New Zealand
KW - Agriculture
KW - Lead Poisoning
KW - Leptospirosis
KW - New Zealand
KW - Occupational Exposure
SP - 6
EP - 7
JO - New Zealand Public Health Surveillance Report
JF - New Zealand Public Health Surveillance Report
JA - NZ PUBLIC HEALTH SURVEILLANCE REP
VL - 6
IS - 4
PB - Institute of Environmental Science & Research Limited
SN - 1176-2888
AD - Public Health Scientist, Medical Office of Health, Auckland Regional Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gallauresi, Beverly Albrecht
AU - Woods, Terry
T1 - Danger: "Sandbag" in the MRI room.
JO - Nursing
JF - Nursing
Y1 - 2008/12//
VL - 38
IS - 12
M3 - Article
SP - 60
EP - 60
SN - 03604039
AB - The article offers guidelines to nurses on how to keep patients, staff and equipment safe in the magnetic resonance imaging (MRI) room. It suggests purchasing sandbags labeled with either the MR Safe or MR. It recommends making sure that ferromagnetic sandbags are labeled as MR Unsafe so that they would not be used in the MRI environment.
KW - IMAGING systems in medicine
KW - DIAGNOSTIC imaging
KW - MAGNETIC resonance imaging
KW - FERROMAGNETISM
KW - MAGNETIC resonance
N1 - Accession Number: 35823261; Gallauresi, Beverly Albrecht 1 Woods, Terry; Affiliation: 1: Center for Devices and Radiological Health; Source Info: Dec2008, Vol. 38 Issue 12, p60; Subject Term: IMAGING systems in medicine; Subject Term: DIAGNOSTIC imaging; Subject Term: MAGNETIC resonance imaging; Subject Term: FERROMAGNETISM; Subject Term: MAGNETIC resonance; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; Number of Pages: 1p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105587809
T1 - Device safety. Danger: 'sandbag' in the MRI room.
AU - Gallauresi BA
AU - Woods T
Y1 - 2008/12//
N1 - Accession Number: 105587809. Language: English. Entry Date: 20090123. Revision Date: 20150820. Publication Type: Journal Article; brief item. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 7600137.
KW - Equipment Safety
KW - Iron Compounds
KW - Magnetic Resonance Imaging -- Adverse Effects
SP - 60
EP - 60
JO - Nursing
JF - Nursing
JA - NURSING
VL - 38
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health
U2 - PMID: 19033995.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Screening for Diabetes: Managing Illness Before It Occurs.
JO - Nursing for Women's Health
JF - Nursing for Women's Health
Y1 - 2008/12//Dec2008/Jan2009
VL - 12
IS - 6
M3 - Article
SP - 472
EP - 474
SN - 17514851
AB - The article offers information on the early detection and screening of diabetes. It accounts the reviews made by the U.S. Preventive Services Task Force (USPSTF) of effectiveness of screening methods for diabetes. It states that based from the recent review of evidence for the screening of type 2 diabetes, the available screening tests accurately detect the disease during an early, asymptotic phase. A discussion of the need for the early detection of diabetes is also offered.
KW - DIABETES -- Diagnosis
KW - NON-insulin-dependent diabetes -- Diagnosis
KW - MEDICAL screening
KW - EVIDENCE-based medicine
KW - U.S. Preventive Services Task Force
KW - UNITED States
N1 - Accession Number: 35538620; Clancy, Carolyn M. 1; Source Information: Dec2008/Jan2009, Vol. 12 Issue 6, p472; Subject: DIABETES -- Diagnosis; Subject: NON-insulin-dependent diabetes -- Diagnosis; Subject: MEDICAL screening; Subject: EVIDENCE-based medicine; Subject: U.S. Preventive Services Task Force; Geographic Terms: UNITED States; Number of Pages: 3p; Illustrations: 2 Color Photographs; Document Type: Article
L3 - 10.1111/j.1751-486X.2008.00379.x
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105605430
T1 - Screening for diabetes: managing illness before it occurs.
AU - Clancy CM
Y1 - 2008/12//Dec2008/Jan2009
N1 - Accession Number: 105605430. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Dec2008/Jan2009. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Public Health; Women's Health. NLM UID: 101304602.
KW - Diabetes Mellitus, Type 2 -- Prevention and Control
KW - Health Screening
KW - Diabetes Mellitus, Gestational
KW - Diabetes Mellitus, Type 2 -- Complications
KW - Diabetes Mellitus, Type 2 -- Diagnosis
KW - Diabetes Mellitus, Type 2 -- Risk Factors
KW - Hypertension
KW - Obesity -- Complications
SP - 472
EP - 474
JO - Nursing for Women's Health
JF - Nursing for Women's Health
JA - NURS WOMENS HEALTH
VL - 12
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1751-4851
AD - Director, Agency for Healthcare Research and Quality, in Rockville, MD
U2 - PMID: 19121050.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Garcia, Joxel
T1 - Essential Surge Capacity.
JO - Officer
JF - Officer
Y1 - 2008/12//
VL - 84
IS - 10
M3 - Article
SP - 52
EP - 53
SN - 00300268
AB - The article highlights the year-end report from the assistance secretary for health for the U.S. Public Health Service (USPHS) Reserve Corps for 2008. It discusses the USPHS' long-term strategy for ensuring response surge capability which includes the development of a Ready Reserve as outlined in the secretary's 2006 Transformation Implementation Plan.
KW - ARMED Forces
KW - MILITARY art & science
KW - MILITARY policy
KW - PUBLIC health
KW - RESERVES
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 35900644; Garcia, Joxel 1; Affiliation: 1: U.S. Public Health Service U.S. Department of Health and Human Services; Source Info: Dec2008, Vol. 84 Issue 10, p52; Subject Term: ARMED Forces; Subject Term: MILITARY art & science; Subject Term: MILITARY policy; Subject Term: PUBLIC health; Subject Term: RESERVES; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 928110 National Security; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Beverly McCabe-Sellers
AU - Dalia Lovera
AU - Henry Nuss
AU - Carolyn Wise
AU - Baitang Ning
AU - Candee Teitel
AU - Beatrice Shelby Clark
AU - Terri Toennessen
AU - Bridgett Green
AU - Margaret L. Bogle
AU - Jim Kaput
T1 - Personalizing Nutrigenomics Research through Community Based Participatory Research and Omics Technologies.
JO - OMICS: A Journal of Integrative Biology
JF - OMICS: A Journal of Integrative Biology
Y1 - 2008/12//
VL - 12
IS - 4
M3 - Article
SP - 263
EP - 272
SN - 15362310
AB - AbstractPersonal and public health information are often obtained from studies of large population groups. Risk factors for nutrients, toxins, genetic variation, and more recently, nutrient–gene interactions are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. Because individuals differ in genetic makeup, lifestyle, and dietary patterns than those individuals in the study population, these risk factors are valuable guidelines, but may not apply to individuals. Intervention studies are likewise limited by small sample sizes, short time frames to assess physiological changes, and variable experimental designs that often preclude comparative or consensus analyses. A fundamental challenge for nutrigenomics will be to develop a means to sort individuals into metabolic groups, and eventually, develop risk factors for individuals. To reach the goal of personalizing medicine and nutrition, new experimental strategies are needed for human study designs. A promising approach for more complete analyses of the interaction of genetic makeups and environment relies on community-based participatory research (CBPR) methodologies. CBPR's central focus is developing a partnership among researchers and individuals in a community that allows for more in depth lifestyle analyses but also translational research that simultaneously helps improve the health of individuals and communities. The USDA–ARS Delta Nutrition Intervention Research program exemplifies CBPR providing a foundation for expanded personalized nutrition and medicine research for communities and individuals. [ABSTRACT FROM AUTHOR]
AB - Copyright of OMICS: A Journal of Integrative Biology is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALNUTRITION
KW - NUTRITION disorders
KW - STARVATION
KW - NUTRITION
KW - CACHEXIA
N1 - Accession Number: 35530594; Beverly McCabe-Sellers 1 Dalia Lovera 1 Henry Nuss 1 Carolyn Wise 2 Baitang Ning 2 Candee Teitel 2 Beatrice Shelby Clark 3 Terri Toennessen 2 Bridgett Green 2 Margaret L. Bogle 1 Jim Kaput 2; Affiliation: 1: USDA—ARS Delta NIRI. 900 South Shackleford Drive, Little Rock, AR 72211. 2: Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research. Jefferson, AR 72079. 3: Boys, Girls, and Adults Community Development Center. Marvell, AR 72366.; Source Info: Dec2008, Vol. 12 Issue 4, p263; Subject Term: MALNUTRITION; Subject Term: NUTRITION disorders; Subject Term: STARVATION; Subject Term: NUTRITION; Subject Term: CACHEXIA; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105474767
T1 - A national profile of the health care experiences and family impact of autism spectrum disorder among children in the United States, 2005-2006.
AU - Kogan MD
AU - Strickland BB
AU - Blumberg SJ
AU - Singh GK
AU - Perrin JM
AU - van Dyck PC
Y1 - 2008/12//
N1 - Accession Number: 105474767. Language: English. Entry Date: 20090515. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Autistic Disorder -- Epidemiology
KW - Autistic Disorder -- Therapy
KW - Child Health Services -- Utilization
KW - Health Resource Utilization -- Statistics and Numerical Data
KW - Adolescence
KW - Autistic Disorder -- Psychosocial Factors
KW - Autistic Disorder -- Rehabilitation
KW - Child
KW - Child, Preschool
KW - Comparative Studies
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Female
KW - Health Resource Utilization -- Economics
KW - Health Services Accessibility -- Statistics and Numerical Data
KW - Logistic Regression
KW - Male
KW - Needs Assessment
KW - Odds Ratio
KW - Outcomes (Health Care)
KW - Parent-Child Relations
KW - United States
KW - Human
SP - e1149
EP - 58
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 122
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: We sought to examine the health care experiences of children with autism spectrum disorder and the impact of autism spectrum disorder on the family and to assess whether having a medical home is associated with less family impact. METHODS: We used the 2005-2006 National Survey of Children With Special Health Care Needs to compare 2088 children with special health care needs, aged 3 to 17 years, reported by their parents to have autism spectrum disorder, with children with special health care needs with 'other emotional, developmental, or behavioral problems' (excluding autism spectrum disorder; n=9534) and 26751 other children with special health care needs. We used weighted logistic regression to examine unmet needs for specific health care and support services, delayed care, no usual care source or personal physician, difficulty receiving referrals, and financial, employment, or time problems because of child's care. RESULTS: Nationally, an estimated 535000 children have special health care needs and autism spectrum disorder, a prevalence of 86 per 10000 children aged 3 to 17 years. Among children with special health care needs, 5.6% have autism spectrum disorder. Compared with other children with special health care needs without emotional, developmental, or behavioral problems, children with special health care needs with autism spectrum disorder were more likely to have unmet needs for specific health care services, family support services, delayed or foregone care, difficulty receiving referrals, and care that is not family centered. Children with special health care needs with autism spectrum disorder were more likely to live in families that report financial problems, need additional income for the child's medical care, reduce or stop work because of the child's condition, spend >or=10 hours per week providing or coordinating care, and paid more than $1000 in the previous year for the child's care. The financial impacts of autism spectrum disorder were significantly more burdensome when children with special health care needs did not have a medical home. CONCLUSIONS: Children with special health care needs with autism spectrum disorder are significantly more likely to have problems regarding access to care and unmet needs, and their families have greater financial, employment, and time burdens compared with other children with special health care needs. Receipt of primary care in a medical home may reduce these burdens.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA. mkogan@hrsa.gov
U2 - PMID: 19047216.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mei-Ling Chen
AU - Vincent Lee
T1 - Equivalence-by-Design: Targeting In Vivo Drug Delivery Profile.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2008/12//
VL - 25
IS - 12
M3 - Article
SP - 2723
EP - 2730
SN - 07248741
AB - Abstract In the United States (U.S.), drug products are considered therapeutically equivalent if they meet regulatory criteria of pharmaceutical equivalence and bioequivalence. These requirements can be traced back to 1977 when the U.S. Food and Drug Administration (FDA) published the regulations on bioavailability and bioequivalence. Over the years, to keep up with the advancement in science and technology, the FDA has been constantly updating the regulatory approaches to assessing and ensuring equivalence. In view of the recent growth in novel pharmaceutical dosage forms and delivery systems, this paper examines the current framework for documentation of therapeutic equivalence and explores the opportunities of further advancing equivalence methods for complex drug products. It is proposed that equivalence may be established by matching the in vivo drug delivery profile (iDDP) between drug products in comparison. This can be achieved by characterizing the iDDP of the reference formulation with application of an equivalence-by-design approach for pharmaceutical development. Critical variables can be identified to serve as in vitro markers or biomarkers for mapping the desired drug delivery profile in vivo. A multidisciplinary approach may be necessary to develop these markers for characterization of iDDPs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG delivery systems
KW - PHARMACEUTICAL industry
KW - BIOAVAILABILITY
KW - MEDICAL publishing
KW - DRUG development
KW - BIOCHEMICAL markers
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 35531670; Mei-Ling Chen 1 Vincent Lee 2; Affiliation: 1: Food and Drug Administration Office of Pharmaceutical Science, Center for Drug Evaluation and Research 10903 New Hampshire Avenue Silver Spring Maryland 20993-0002 USA 2: The Chinese University of Hong Kong School of Pharmacy, Faculty of Medicine Shatin N.T. Hong Kong SAR; Source Info: Dec2008, Vol. 25 Issue 12, p2723; Subject Term: DRUG delivery systems; Subject Term: PHARMACEUTICAL industry; Subject Term: BIOAVAILABILITY; Subject Term: MEDICAL publishing; Subject Term: DRUG development; Subject Term: BIOCHEMICAL markers; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore, Kristen M.
AU - Duddy, April
AU - Braun, M. Miles
AU - Platt, Richard
AU - Brown, Jeffrey S.
T1 - Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event detection: a survey of health plans.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/12//
VL - 17
IS - 12
M3 - Article
SP - 1137
EP - 1141
SN - 10538569
AB - Purpose A vaccine against pandemic influenza may be rapidly and widely distributed, and could be used in populations with little prior exposure to influenza vaccines. Under such conditions, it will be important to gain timely information about the rates of vaccine adverse events, ideally by using electronic data from large populations. Many public and private health plans and payers have such information. Methods Between May and September 2007, we conducted a decision maker interview and technical assessment with several health plans in the United States. The interview and survey evaluated technical capability, organizational capacity, and willingness to participate in a coordinated program of rapid safety research targeting pandemic and other influenza vaccines. Results Eleven health plans (eight private, three public) participated in the decision maker interview. Most interviewees were medical directors or held similar positions within their organizations. Participating plans provided coverage and/or care for approximately 150 million members in the U.S. Nine health plans completed a technical assessment survey. Most decision makers indicated interest and willingness to participate in a coordinated rapid safety surveillance program, and all reported the necessary claims data analysis experience. Respondents noted legal, procedural, budgetary, and technical barriers to participation. Conclusions Senior decision makers representing private and public health plans were willing and asserted the ability of their organizations to participate in pandemic influenza vaccine safety monitoring. Developing working relationships, negotiating contracts, and obtaining necessary regulatory and legal approvals were identified as key barriers. These findings may be generalizable to other vaccines and pharmaceutical products. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707284; Moore, Kristen M. 1,2; Duddy, April 1,2; Braun, M. Miles 3; Platt, Richard 1,2; Brown, Jeffrey S. 1,2; Affiliations: 1: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA; 2: The HMO Research Network Center for Education and Research in Therapeutics, Boston, MA, USA; 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: Dec2008, Vol. 17 Issue 12, p1137; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.1642
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hammad, Tarek A.
AU - McAdams, Mara A.
AU - Feight, Andrea
AU - Iyasu, Solomon
AU - Dal Pan, Gerald J.
T1 - Determining the predictive value of Read/OXMIS codes to identify incident acute myocardial infarction in the General Practice Research Database.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2008/12//
VL - 17
IS - 12
M3 - Article
SP - 1197
EP - 1201
SN - 10538569
AB - Purpose To determine (1) the positive predictive value (PPV) of multiple Read/OXMIS codes to identify incident acute myocardial infarction (AMI) cases in General Practice Research Database (GPRD); (2) the ability to capture the correct timing of the clinical event. Methods A random sample of 238 records (from 155 general practitioner (GP) practices) with AMI codes, between 1 January 1997 and 31 December 2004, was selected from GPRD. Questionnaires were sent to the GPs to verify the diagnosis and timing of code-identified incident AMI events and collect supporting information. We calculated the PPV of the AMI codes as the proportion of code-identified AMIs that the GPs confirmed as AMI cases. Two physicians from Food and Drug administration (FDA), blinded to the GP response, reviewed the supporting hospital records returned by GPs for 98 AMI cases. Results A total of 217 questionnaires were completed (91% response rate). The PPV of the AMI codes was 93% (201/217). Thirty one (15%) cases had a different event date than the one recorded in the electronic medical records (EMR); 28 (90%) of the dates were within 15 days. One GP indicated that a patient had a previous AMI, 110 days before the codes that captured the AMI diagnosis. A total of 159 (79%) AMI cases were hospitalized; hospital records were provided for 98 patients. Physician review of the hospital records found that 96% of these records had enough information for classification, but not independent diagnosis, of AMI. Conclusions Information in GPRD is sufficient to identify incident AMI cases and determine the event date with reasonable accuracy. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707287; Hammad, Tarek A. 1; McAdams, Mara A. 1; Feight, Andrea 1; Iyasu, Solomon 1; Dal Pan, Gerald J. 1; Affiliations: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Issue Info: Dec2008, Vol. 17 Issue 12, p1197; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.1672
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Goodsaid, Federico M.
T1 - Modulation of Clopidogrel Pharmacodynamic Response.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2008/12//
VL - 28
IS - 12
M3 - Article
SP - 1423
EP - 1424
SN - 02770008
AB - The article discusses a study conducted by N. A. Farid et al. about the uncertainty in the drug-drug interaction between clopidogrel and lipophilic statins. Under the study, measurements of the plasma concentrations of the active metabolite of thienopyridine clopidogrel as well as the pharmacodynamic response to the drug were taken. The study affirms that there are differences in the drug-drug interactions of clopidogrel and prasugrel with ketoconazole. It adds that cytochrome P450 (CYP) 3A4 inhibitors have minimal effect on drug responses.
KW - DRUG interactions
KW - ANTICOAGULANTS (Medicine)
KW - STATINS (Cardiovascular agents)
KW - DRUGS -- Side effects
KW - DRUGS -- Physiological effect
KW - METABOLITES
KW - KETOCONAZOLE
KW - CYTOCHROME P-450
KW - clopidogrel
KW - drug-drug interactions
KW - pharmacodynamics
KW - pharmacogenomics
KW - platelet aggregation
KW - prasugrel
KW - thienopyridines
N1 - Accession Number: 35741364; Goodsaid, Federico M. 1; Email Address: ederico.goodsaid@fda.hhs.gov; Affiliation: 1: Genomics Group, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration; Source Info: Dec2008, Vol. 28 Issue 12, p1423; Subject Term: DRUG interactions; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: STATINS (Cardiovascular agents); Subject Term: DRUGS -- Side effects; Subject Term: DRUGS -- Physiological effect; Subject Term: METABOLITES; Subject Term: KETOCONAZOLE; Subject Term: CYTOCHROME P-450; Author-Supplied Keyword: clopidogrel; Author-Supplied Keyword: drug-drug interactions; Author-Supplied Keyword: pharmacodynamics; Author-Supplied Keyword: pharmacogenomics; Author-Supplied Keyword: platelet aggregation; Author-Supplied Keyword: prasugrel; Author-Supplied Keyword: thienopyridines; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dalmasso, Cyril
AU - Carpentier, Wassila
AU - Meyer, Laurence
AU - Rouzioux, Christine
AU - Goujard, Cécile
AU - Chaix, Marie-Laure
AU - Lambotte, Olivier
AU - Avettand-Fenoel, Véronique
AU - Le Clerc, Sigrid
AU - de Senneville, Laure Denis
AU - Deveau, Christiane
AU - Boufassa, Faroudy
AU - Debré, Patrice
AU - Delfraissy, Jean-François
AU - Broet, Philippe
AU - Theodorou, Ioannis
T1 - Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2008/12//
VL - 3
IS - 12
M3 - Article
SP - 1
EP - 11
PB - Public Library of Science
SN - 19326203
AB - Previous studies of the HIV-1 disease have shown that HLA and Chemokine receptor genetic variants influence disease progression and early viral load. We performed a Genome Wide Association study in a cohort of 605 HIV-1-infected seroconverters for detection of novel genetic factors that influence plasma HIV-RNA and cellular HIV-DNA levels. Most of the SNPs strongly associated with HIV-RNA levels were localised in the 6p21 major histocompatibility complex (MHC) region and were in the vicinity of class I and III genes. Moreover, protective alleles for four disease-associated SNPs in the MHC locus (rs2395029, rs13199524, rs12198173 and rs3093662) were strikingly over-represented among forty-five Long Term HIV controllers. Furthermore, we show that the HIV-DNA levels (reflecting the HIV reservoir) are associated with the same four SNPs, but also with two additional SNPs on chromosome 17 (rs6503919; intergenic region flanked by the DDX40 and YPEL2 genes) and chromosome 8 (rs2575735; within the Syndecan 2 gene). Our data provide evidence that the MHC controls both HIV replication and HIV reservoir. They also indicate that two additional genomic loci may influence the HIV reservoir. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOCUS (Genetics)
KW - HIV (Viruses)
KW - DNA
KW - RNA
KW - HLA histocompatibility antigens
KW - CHEMOKINES
KW - MAJOR histocompatibility complex
KW - CHROMOSOMES
KW - VIRAL replication
N1 - Accession Number: 55637198; Dalmasso, Cyril 1 Carpentier, Wassila 2 Meyer, Laurence 3 Rouzioux, Christine 4 Goujard, Cécile 5 Chaix, Marie-Laure 4 Lambotte, Olivier 5 Avettand-Fenoel, Véronique 4 Le Clerc, Sigrid 6 de Senneville, Laure Denis 2 Deveau, Christiane 3 Boufassa, Faroudy 3 Debré, Patrice 2 Delfraissy, Jean-François 5 Broet, Philippe 1,7 Theodorou, Ioannis 2; Email Address: ioannis.theodorou@psl.ap-hop-paris.fr; Affiliation: 1: JE2492, Faculty of Medicine Paris-Sud, Univ Paris-Sud, Villejuif, France 2: CHU Pitié Salpetrière (AP-HP), INSERM U543, Université Pierre et Marie Curie, Paris, France, 3: INSERM, U822, Univ Paris-Sud, Faculté de Médecine Paris-Sud, AP-HP, Hopital Bicêtre, Epidemiology and Public Health Service, Le Kremlin-Bicêtre, France 4: CHU Necker (AP-HP) EA 3620 Université Paris Descartes, Paris, France 5: CHU Kremlin Bicêtre (AP-HP); INSERM, U802, Univ Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin-Bicê tre, France 6: Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, Paris, France 7: Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Paul Brousse, Service de Santé Publique, Univ Paris-Sud, Villejuif, France; Source Info: 2008, Vol. 3 Issue 12, p1; Subject Term: LOCUS (Genetics); Subject Term: HIV (Viruses); Subject Term: DNA; Subject Term: RNA; Subject Term: HLA histocompatibility antigens; Subject Term: CHEMOKINES; Subject Term: MAJOR histocompatibility complex; Subject Term: CHROMOSOMES; Subject Term: VIRAL replication; Number of Pages: 11p; Illustrations: 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0003907
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harris, Marcia L.
AU - Mainiero, Richard J.
T1 - Monitoring and removal of CO in blasting operations
JO - Safety Science
JF - Safety Science
Y1 - 2008/12//
VL - 46
IS - 10
M3 - Article
SP - 1393
EP - 1405
SN - 09257535
AB - Abstract: Toxic fumes produced by detonating explosives in surface mining and construction operations pose potential hazards to workers and the public. Blasting operations produce both toxic and nontoxic gaseous products; the toxic products are mainly carbon monoxide (CO) and the oxides of nitrogen (NO x ). Since 1988, there have been 17 documented incidents in the United States and Canada in which carbon monoxide (CO) is suspected to have migrated through ground strata into occupied enclosed spaces as a result of proximate trench blasting or surface mine blasting. These incidents resulted in 39 suspected or medically verified carbon monoxide poisonings as well as one fatality. At worst people may be fatally poisoned and the least to be expected is increased public objections to blasting. Local and state agencies could demand a cessation of the blasting requiring more expensive mechanical means to break the rock. This paper discusses the most feasible means of preventing CO migration, mitigating CO that has migrated, and detecting CO in an underground enclosed space and may help reduce the exposure of unsuspecting area residents to carbon monoxide and help prevent the implementation of unnecessary regulations and limitations on blasting. Single-hole shots and small-scale multiple-hole blasts were performed that indicate promising means of prevention and mitigation. [Copyright &y& Elsevier]
AB - Copyright of Safety Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carbon monoxide
KW - Strip mining
KW - Nitrogen oxides
KW - Hazardous substances
KW - Blasting
KW - Explosives
KW - CO poisoning
KW - Fumes
N1 - Accession Number: 35071887; Harris, Marcia L.; Email Address: mharris@cdc.gov; Mainiero, Richard J. 1; Email Address: rmainiero@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, USA; Issue Info: Dec2008, Vol. 46 Issue 10, p1393; Thesaurus Term: Carbon monoxide; Thesaurus Term: Strip mining; Thesaurus Term: Nitrogen oxides; Thesaurus Term: Hazardous substances; Subject Term: Blasting; Subject Term: Explosives; Author-Supplied Keyword: CO poisoning; Author-Supplied Keyword: Fumes; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213119 Other support activities for mining; NAICS/Industry Codes: 213115 Support Activities for Nonmetallic Minerals (except Fuels) Mining; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 325920 Explosives Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 333130 Mining and oil and gas field machinery manufacturing; NAICS/Industry Codes: 212114 Bituminous coal mining; NAICS/Industry Codes: 212113 Anthracite Mining; NAICS/Industry Codes: 212111 Bituminous Coal and Lignite Surface Mining; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.ssci.2007.10.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Sharpening the focus on occupational safety and health in nanotechnology.
AU - Schulte, Paul
AU - Geraci, Charles
AU - Zumwalde, Ralph
AU - Hoover, Mark
AU - Castranova, Vincent
AU - Kuempel, Eileen
AU - Murashov, Vladimir
AU - Vainio, Harri
AU - Savolainen, Kai
JO - Scandinavian Journal of Work, Environment & Health
JF - Scandinavian Journal of Work, Environment & Health
Y1 - 2008/12//
VL - 34
IS - 6
SP - 471
EP - 478
SN - 03553140
N1 - Accession Number: 35999360; Author: Schulte, Paul: 1 email: PSchulte@cdc.gov. Author: Geraci, Charles: 1 Author: Zumwalde, Ralph: 1 Author: Hoover, Mark: 1 Author: Castranova, Vincent: 1 Author: Kuempel, Eileen: 1 Author: Murashov, Vladimir: 1 Author: Vainio, Harri: 2 Author: Savolainen, Kai: 2 ; Author Affiliation: 1 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, United States: 2 Finnish Institute of Occupational Health, Helsinki, Finland; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20090109
N2 - The article provides information on the measures aiming at sharpening the focus on occupational safety and health in nanotechnology. Hazard classification of engineered particles, exposure metrics, actual exposures to various engineered nanoparticles in the workplace, limits of engineering controls, equipment, and programs which protect employees from hazard are explored in the article.
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL safety
KW - NANOTECHNOLOGY
KW - HAZARDOUS substances -- Safety measures
KW - ENGINEERING
KW - engineering
KW - exposure
KW - hazard
KW - nanoparticle
KW - risk
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Taitt, Chris Rowe
AU - Shriver-Lake, Lisa C.
AU - Ngundi, Miriam M.
AU - Ligler, Frances S.
T1 - Array Biosensor for Toxin Detection: Continued Advances.
JO - Sensors (14248220)
JF - Sensors (14248220)
Y1 - 2008/12//
VL - 8
IS - 12
M3 - Article
SP - 8361
EP - 8377
SN - 14248220
AB - The following review focuses on progress made in the last five years with the NRL Array Biosensor, a portable instrument for rapid and simultaneous detection of multiple targets. Since 2003, the Array Biosensor has been automated and miniaturized for operation at the point-of-use. The Array Biosensor has also been used to demonstrate (1) quantitative immunoassays against an expanded number of toxins and toxin indicators in food and clinical fluids, and (2) the efficacy of semi-selective molecules as alternative recognition moieties. Blind trials, with unknown samples in a variety of matrices, have demonstrated the versatility, sensitivity, and reliability of the automated system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sensors (14248220) is the property of MDPI Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - MEDICAL equipment
KW - DETECTORS
KW - PHYSIOLOGICAL apparatus
KW - TOXINS
KW - ANTIGENS
KW - IMMUNOASSAY
KW - biosensor
KW - clinical diagnostics
KW - detection
KW - food
KW - multi-analyte
KW - multiplex
KW - toxin
N1 - Accession Number: 42857371; Taitt, Chris Rowe 1; Email Address: chris.taitt@nrl.navy.mil Shriver-Lake, Lisa C. 1; Email Address: lisa.shriverlake@nrl.navy.mil Ngundi, Miriam M. 2; Email Address: Miriam.Ngundi@fda.hhs.gov Ligler, Frances S. 1; Email Address: frances.ligler@nrl.navy.mil; Affiliation: 1: Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Code 6900, Washington, DC 20375-5348, USA 2: Food and Drug Administration, N29 RM418 HFM-434, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: 2008, Vol. 8 Issue 12, p8361; Subject Term: BIOSENSORS; Subject Term: MEDICAL equipment; Subject Term: DETECTORS; Subject Term: PHYSIOLOGICAL apparatus; Subject Term: TOXINS; Subject Term: ANTIGENS; Subject Term: IMMUNOASSAY; Author-Supplied Keyword: biosensor; Author-Supplied Keyword: clinical diagnostics; Author-Supplied Keyword: detection; Author-Supplied Keyword: food; Author-Supplied Keyword: multi-analyte; Author-Supplied Keyword: multiplex; Author-Supplied Keyword: toxin; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 17p; Illustrations: 1 Color Photograph, 2 Black and White Photographs, 1 Diagram, 1 Graph; Document Type: Article
L3 - 10.3390/s8128361
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105447488
T1 - Advancing mental health research: Washington University's center for mental health services research.
AU - Proctor EK
AU - McMillen C
AU - Haywood S
AU - Dore P
Y1 - 2008/12//
N1 - Accession Number: 105447488. Language: English. Entry Date: 20090320. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology; Social Work. NLM UID: 9434315.
KW - Research, Mental Health
KW - Research, Social Work
KW - Colleges and Universities -- Washington
KW - Data Management
KW - Leadership
KW - Membership
KW - Mental Health Services
KW - National Institute of Mental Health (U.S.)
KW - Research Personnel
KW - Research Support
KW - Washington
SP - 249
EP - 259
JO - Social Work Research
JF - Social Work Research
JA - SOC WORK RES
VL - 32
IS - 4
PB - Oxford University Press / USA
AB - Research centers have become a key component ofthe research infrastructure in schools ofsocial work, including the George Warren Brown School of SocialWork at Washington University. In 1993, that school's Center for Mental Health Services Research (CMHSR) received funding from the National Institute ofMental Health (NIMH) as a Social Work Research Development Center (R24 MH50857), with a renewal in 1999 for five more years ofsupport. After the program announcement for the social work research development center mechanism expired, the center applied under an 'advanced' mechanism and in 2004 was awarded five years offunding as an NIMH Advanced Center for Interventions and Services Research (P30 MH068579). This article describes the background for developing the center, the center's aims and research agenda, its structure and functioning, and outcomes of CMHSR from 1993 to the present.
SN - 1070-5309
AD - Center for Mental Health Services Research (CMSHR)
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - He, Qinghang
AU - Zhang, Zhenxi
AU - Yi, Chao
T1 - 3D fluorescence spectral data interpolation by using IDW
JO - Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy
JF - Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy
Y1 - 2008/12//
VL - 71
IS - 3
M3 - Article
SP - 743
EP - 745
SN - 13861425
AB - Abstract: Because measured precision of some spectral instruments such as fluorescence spectrometer HITACHI F-4500 cannot reach the requirement of spectral analytical technique, and measured data is finite, which causes some three-dimensional (3D) fluorescence spectral data missed. The fact of missing data can result in errors in interpretations of 3D fluorescence spectral data. This paper takes ethanol solution (volume percentage φ β =0.400) 3D fluorescence spectral data for example, applies inverse distance weighting (IDW) to 3D fluorescence spectral data interpolation. The results prove that the more details of 3D fluorescence spectra are expressed well by using IDW in contrast to that of original 3D fluorescence spectra. To evaluate the effectiveness of interpolation by using IDW, this paper compares standard deviation, coefficient of variation, and the mean, median, maximum and minimum values of original ethanol solution (φ β =0.400) 3D fluorescence spectral data and that of the interpolated, whose results suggest that the interpolation of the 3D fluorescence spectra data by using IDW is exact. [Copyright &y& Elsevier]
AB - Copyright of Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUORESCENCE spectroscopy
KW - WEIGHTING
KW - ALCOHOL
KW - INTERPOLATION
KW - STANDARD deviations
KW - SPECTRUM analysis
KW - 3D fluorescence spectral data interpolation
KW - Excitation–emission matrix
KW - Inverse distance weighting
N1 - Accession Number: 34898261; He, Qinghang 1,2 Zhang, Zhenxi 1; Email Address: zxzhang@mail.xjtu.edu.cn Yi, Chao 1; Affiliation: 1: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, 710049, PR China 2: Xiamen Food and Drug Administration, Xiamen, 361004, PR China; Source Info: Dec2008, Vol. 71 Issue 3, p743; Subject Term: FLUORESCENCE spectroscopy; Subject Term: WEIGHTING; Subject Term: ALCOHOL; Subject Term: INTERPOLATION; Subject Term: STANDARD deviations; Subject Term: SPECTRUM analysis; Author-Supplied Keyword: 3D fluorescence spectral data interpolation; Author-Supplied Keyword: Excitation–emission matrix; Author-Supplied Keyword: Inverse distance weighting; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.saa.2007.11.041
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Moos, Malcolm
T1 - Stem-cell-derived products: an FDA update
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
Y1 - 2008/12//
VL - 29
IS - 12
M3 - Editorial
SP - 591
EP - 593
SN - 01656147
AB - The therapeutic potential of products derived from stem cells of various types has prompted increasing research and development and public attention. Initiation of human clinical trials in the not-too-distant future is now a realistic possibility. It is, therefore, important to weigh the potential benefits against known, theoretical and totally unsuspected risks in light of current knowledge to ensure that subjects participating in these trials are afforded the most reasonable balance possible between potential risks and potential benefits. There are no apparent differences in fundamental, qualitative biological characteristics between stem-cell-derived products and other cellular therapies regulated by the United States Food and Drug Administration (FDA). Existing authorities can, therefore, be applied. Nevertheless, these products do have properties that require careful evaluation. [Copyright &y& Elsevier]
AB - Copyright of Trends in Pharmacological Sciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STEM cell research
KW - CLINICAL trials
KW - CELLS
KW - RESEARCH
N1 - Accession Number: 35501348; Moos, Malcolm 1; Email Address: malcolm.moos@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, 20892, USA; Source Info: Dec2008, Vol. 29 Issue 12, p591; Subject Term: STEM cell research; Subject Term: CLINICAL trials; Subject Term: CELLS; Subject Term: RESEARCH; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 3p; Document Type: Editorial
L3 - 10.1016/j.tips.2008.09.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35501348&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Steven R. Hinten
AU - Geoffrey A. Beckett
AU - Kathleen F. Gensheimer
AU - Elizabeth Pritchard
AU - Thomas M. Courtney
AU - Stephen D. Sears
AU - John M. Woytowicz
AU - David G. Preston
AU - Robert P. Smith Jr.
AU - Peter W. Rand
AU - Eleanor H. Lacombe
AU - Mary S. Holman
AU - Charles B. Lubelczyk
AU - Patsy Tassler Kelso
AU - Andrew P. Beelen
AU - Mary Grace Stobierski
AU - Mark J. Sotir
AU - Susan Wong
AU - Gregory Ebel
AU - Olga Kosoy
T1 - Increased Recognition of Powassan Encephalitis in the United States, 1999–2005.
JO - Vector Borne & Zoonotic Diseases
JF - Vector Borne & Zoonotic Diseases
Y1 - 2008/12//
VL - 8
IS - 6
M3 - Article
SP - 733
EP - 740
SN - 15303667
AB - Powassan virus (POWV) disease is a rare human disease caused by a tick-borne encephalitis group flavivirus maintained in a transmission cycle between Ixodes cookeiand other ixodid ticks and small and medium-sized mammals. During 1958–1998, only 27 POWV disease cases (mostly Powassan encephalitis) were reported from eastern Canada and the northeastern United States (average, 0.7 cases per year). During 1999–2005, nine cases (described herein) of serologically confirmed POWV disease were reported in the United States (average, 1.3 cases per year) four from Maine, two from New York, and one each from Michigan, Vermont, and Wisconsin. The Michigan and Wisconsin cases are the first ever reported from the north-central United States. Of these nine patients, 5 (56) were men, the median age was 69 years (range 25-91 years), and 6 (67) had onset during May–July. All but one patient developed encephalitis with acute onset of profound muscle weakness, confusion, and other severe neurologic signs. In one case, no neurologic symptoms were present but the presence of pleocytosis, an elevated cerebrospinal fluid (CSF) protein concentration, and POWV-specific immunoglobulin M in CSF suggested neuroinvasion. All patients recovered from their acute disease, but most had long-term neurologic sequelae. Periresidential ecologic investigations were performed in three cases, including tests of local mammals and ticks for evidence of POWV infection. Woodchucks (Marmota monax), striped skunks (Mephitis mephitis), and a raccoon (Procyon lotor) collected at two of the Maine case-patients'' residences had neutralizing antibody titers to POWV. I. cookeiwere found on woodchucks and skunks and questing in grassy areas of one of these residences; all were negative for POWV. Although POWV disease is rare, it is probably under-recognized, and it causes significant morbidity, and thus is an additional tick-borne emerging infectious disease entity. Because no vaccine or specific therapy is available, the basis of prevention is personal protection from ticks (or “tick hygiene”) and reduced exposure to peridomestic wild mammals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vector Borne & Zoonotic Diseases is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Encephalitis
KW - Communicable diseases -- Transmission
KW - Skunks
KW - Powassan (Disease)
KW - Public health -- United States
KW - Cerebrospinal fluid
KW - Maine
KW - Michigan
N1 - Accession Number: 35747016; Steven R. Hinten 1,2,3; Geoffrey A. Beckett 4; Kathleen F. Gensheimer 4; Elizabeth Pritchard 5; Thomas M. Courtney 6; Stephen D. Sears 7,8; John M. Woytowicz 7; David G. Preston 9; Robert P. Smith Jr. 10; Peter W. Rand 10; Eleanor H. Lacombe 10; Mary S. Holman 10; Charles B. Lubelczyk 10; Patsy Tassler Kelso 11; Andrew P. Beelen 12; Mary Grace Stobierski 13; Mark J. Sotir 14,15; Susan Wong 16; Gregory Ebel 17; Olga Kosoy 1; Affiliations: 1: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Fort Collins, Colorado.; 2: Epidemiology Program Office, Division of Applied Public Health Training, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia.; 3: Department of Defense.; 4: Division of Disease Control, Bureau of Health, Maine Department of Human Services, Augusta, Maine.; 5: Maine Health & Environmental Testing Laboratory, Maine Department of Heath and Human Services, Augusta, Maine.; 6: Southern Maine Medical Center, Biddeford, Maine.; 7: Maine General Medical Center, Augusta, Maine.; 8: Mercy Hospital, Portland, Maine.; 9: Maine General Medical Center, Waterville, Maine.; 10: Vector-Borne Disease Laboratory, Maine Medical Center Research Institute, South Portland, Maine.; 11: Division of Health Surveillance, Vermont Department of Health, Burlington, Vermont.; 12: Veterans Affairs Medical Center, White River Junction, Vermont.; 13: Communicable Disease Division, Bureau of Epidemiology, Michigan Department of Community Health, Lansing, Michigan.; 14: Wisconsin Division of Public Health, Madison, Wisconsin.; 15: Division of Foodborne, Bacterial, and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta Georgia.; 16: Wadsworth Center, New York State Department of Health, Albany, New York.; 17: Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico.; Issue Info: Dec2008, Vol. 8 Issue 6, p733; Thesaurus Term: Encephalitis; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Skunks; Subject Term: Powassan (Disease); Subject Term: Public health -- United States; Subject Term: Cerebrospinal fluid; Subject: Maine; Subject: Michigan; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35747016&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2008-18608-003
AN - 2008-18608-003
AU - Sublet, Virginia H.
AU - Lum, Max R.
T1 - Use of health communication and social marketing principles in planning occupational safety and health interventions.
JF - Social Marketing Quarterly
JO - Social Marketing Quarterly
JA - Soc Mar Q
Y1 - 2008///Win 2008
VL - 14
IS - 4
SP - 45
EP - 70
CY - United Kingdom
PB - Taylor & Francis
SN - 1524-5004
SN - 1539-4093
N1 - Accession Number: 2008-18608-003. Partial author list: First Author & Affiliation: Sublet, Virginia H.; Office of Health Communication and Global Collaborations, National Institute for Occupational Safety and Health (NIOSH), Washington, DC, US. Other Publishers: Sage Publications. Release Date: 20091116. Correction Date: 20120116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Intervention; Occupational Safety; Social Marketing. Minor Descriptor: Communication; Health. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 26. Issue Publication Date: Win 2008.
AB - This study reviewed health communication and social marketing designs used in occupational safety and health interventions over the last 15 years in the United States. After an extensive literature review, 50 studies were identified that self-reported use of health communication and/or social marketing principles and practices to design occupational safety interventions. Nineteen of these studies were selected for analysis based on the following factors: the inclusion of a behavioral theory, strong study design, an intervention was conducted, and an evaluation was completed. Results indicated that all of the interventions met the criteria to be classified as a health communication intervention, but none met the complete criteria to be considered a true social marketing intervention. Limitations in the evaluation designs made it difficult to assess the impact of these interventions; however, results suggest that health communication principles have been applied widely, while social marketing techniques are poorly understood and underutilized in planning occupational safety programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health communication
KW - social marketing
KW - planning occupational safety
KW - health intervention
KW - 2008
KW - Intervention
KW - Occupational Safety
KW - Social Marketing
KW - Communication
KW - Health
KW - 2008
DO - 10.1080/15245000802542061
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18608-003&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18778-005
AN - 2008-18778-005
AU - Bartlett, Edward E.
T1 - International analysis of institutional review boards registered with the U.S. Office for Human Research Protection.
JF - Journal of Empirical Research on Human Research Ethics
JO - Journal of Empirical Research on Human Research Ethics
JA - J Empir Res Hum Res Ethics
Y1 - 2008/12//
VL - 3
IS - 4
SP - 49
EP - 56
CY - US
PB - University of California Press
SN - 1556-2646
SN - 1556-2654
AD - Bartlett, Edward E., Office for Human Research Protections, 1101 Wootton Parkway, Suite 200, Rockville, MD, US, 20852
N1 - Accession Number: 2008-18778-005. PMID: 19385756 Partial author list: First Author & Affiliation: Bartlett, Edward E.; U.S. Office for Human Research Protections, Rockville, MD, US. Other Publishers: Sage Publications. Release Date: 20091109. Correction Date: 20141124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimental Ethics. Minor Descriptor: Experimentation. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). Location: Asia; Africa; Europe; US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2008. Publication History: Revised Date: Oct 23, 2008; First Submitted Date: Jan 5, 2008. Copyright Statement: All Rights Reserved. Joan Sieber. 2008.
AB - Institutional review boards form the backbone of the human subject protection system. Yet little is known about the characteristics of these committees. This study compiles and analyzes the data on 1,326 IRBs in 113 countries registered with the Office for Human Research Protections. The study analyzes data on the following IRB characteristics: institutional affiliation, number of full-time administrative positions, approximate total number of protocols, and number of currently active protocols supported by DHHS or regulated by the Food and Drug Administration. The analysis found that the most common IRB profile is to be affiliated with a clinical organization (41.9% of IRBs) and to have one full-time staff member (40.0%). Regarding protocol volume, the most common IRB profile was to have 26–99 currently active protocols (42.0% of IRBs), to have 1–25 DHHS protocols (46.6%), and 1–25 FDA-regulated protocols (45.6%). Further analyses reveal considerable differences among countries. This study can provide a baseline for future IRB evaluations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - human subject protection system
KW - research ethics
KW - 2008
KW - Experimental Ethics
KW - Experimentation
KW - 2008
DO - 10.1525/jer.2008.3.4.49
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18778-005&site=ehost-live&scope=site
UR - Edward.bartlett@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18608-006
AN - 2008-18608-006
AU - Hudson, Heidi
AU - Snawder, John
AU - Esswein, Eric
AU - Striley, Cynthia
T1 - Partnering and consumer orientation: Techniques that move occupational safety and health research into practice.
JF - Social Marketing Quarterly
JO - Social Marketing Quarterly
JA - Soc Mar Q
Y1 - 2008///Win 2008
VL - 14
IS - 4
SP - 99
EP - 104
CY - United Kingdom
PB - Taylor & Francis
SN - 1524-5004
SN - 1539-4093
N1 - Accession Number: 2008-18608-006. Partial author list: First Author & Affiliation: Hudson, Heidi; U.S. Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Other Publishers: Sage Publications. Release Date: 20091116. Correction Date: 20120116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Consumer Behavior; Methamphetamine; Occupational Safety. Minor Descriptor: Experimentation; Health; Private Sector; Technology. Classification: Personnel Attitudes & Job Satisfaction (3650); Consumer Attitudes & Behavior (3920). Population: Human (10). Page Count: 6. Issue Publication Date: Win 2008.
AB - First responders, remediation workers, and other personnel frequently encounter clandestine methamphetamine (meth) labs or previous meth lab sites while performing their everyday jobs. National Institute for Occupational Safety and Health (NIOSH) researchers developed a real-time method for detecting methamphetamine on surfaces for use by these workers. This case study describes how a federal agency developed and field-tested this innovative technology and collaborated with a private sector partner to commercialize and market the technology and the impact these actions had on its transfer and adoption. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consumer orientation
KW - occupational safety
KW - health research
KW - methamphetamine
KW - private sector
KW - technology
KW - 2008
KW - Consumer Behavior
KW - Methamphetamine
KW - Occupational Safety
KW - Experimentation
KW - Health
KW - Private Sector
KW - Technology
KW - 2008
DO - 10.1080/15245000802487564
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18608-006&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16672-001
AN - 2008-16672-001
AU - Wolff, Nancy
AU - Shi, Jing
AU - Blitz, Cynthia L.
T1 - Racial and ethnic disparities in types and sources of victimization inside prison.
JF - The Prison Journal
JO - The Prison Journal
JA - Prison J
Y1 - 2008/12//
VL - 88
IS - 4
SP - 451
EP - 472
CY - US
PB - Sage Publications
SN - 0032-8855
SN - 1552-7522
N1 - Accession Number: 2008-16672-001. Partial author list: First Author & Affiliation: Wolff, Nancy; Program in Public Policy, EJ Bloustein School of Planning and Public Policy, Rutgers University, New Brunswick, NJ, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Prisons; Racial and Ethnic Differences; Victimization. Minor Descriptor: Physical Abuse; Prisoners; Racial and Ethnic Relations; Racism; Sexual Abuse; Violence. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: National Violence Against Women and Men Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 22. Issue Publication Date: Dec, 2008. Copyright Statement: Sage Publications. 2008.
AB - Interracial patterns in sexual violence between inmate groups are well documented. Considerably less is known about the interracial pattern of sexual violence as well as physical violence between staff and inmates. This article provides rates of victimization for a single prison system by racial and ethnic groupings and by type of perpetrator. Racial and ethnic patterns were found in prevalence rates by types of victimization and type of perpetrator, but they do not appear to be principally explained by racism. Preventing violence inside prison should include reducing opportunities for victimization as well as 'pulling up' the environment by training officers and other staff in supervisory styles that affirm and preserve a 'harm-free' environment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial and ethnic disparities
KW - victimization
KW - prisons
KW - prisoners
KW - interracial patterns
KW - physical violence
KW - sexual violence
KW - racism
KW - prevalence rates
KW - 2008
KW - Epidemiology
KW - Prisons
KW - Racial and Ethnic Differences
KW - Victimization
KW - Physical Abuse
KW - Prisoners
KW - Racial and Ethnic Relations
KW - Racism
KW - Sexual Abuse
KW - Violence
KW - 2008
U1 - Sponsor: Office of Justice Programs. Grant: OJP- 2004-RP-BX-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20 MH66170. Recipients: No recipient indicated
DO - 10.1177/0032885508325392
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16672-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18582-008
AN - 2008-18582-008
AU - Power, A. Kathryn
AU - Chawla, Neelu
T1 - Transformations in collaborative healthcare.
T3 - From the Annual Meeting of the Collaborative Family Healthcare Association
JF - Families, Systems, & Health
JO - Families, Systems, & Health
JA - Fam Syst Health
Y1 - 2008/12//
VL - 26
IS - 4
SP - 459
EP - 465
CY - US
PB - Educational Publishing Foundation
SN - 1091-7527
SN - 1939-0602
AD - Power, A. Kathryn, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, 1 Choke Cherry Road, Rockville, MD, US, 20857
N1 - Accession Number: 2008-18582-008. Other Journal Title: Family Systems Medicine. Partial author list: First Author & Affiliation: Power, A. Kathryn; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville, MD, US. Other Publishers: Brunner/Mazel Publishers, Inc.; Families, Systems & Health, Inc.; Family Process, Inc.; Family Systems Medicine, Inc. Release Date: 20090105. Correction Date: 20100927. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Collaborative Family Healthcare Conference, 2006, Newport, RI, US. Conference Note: This article is based on a keynote address by A. Kathryn Power at the aforementioned conference. Major Descriptor: Drug Abuse; Mental Health; Mental Health Services; Primary Health Care. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Canada; US. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2008. Copyright Statement: Public Domain
AB - This article describes federal initiatives from the Substance Abuse and Mental Health Services Administration (SAMHSA) aimed at transforming mental health systems towards integration with primary care, discusses potential barriers to integration and how collaborators are thinking about overcoming these barriers, and shares success stories from two integration initiatives that have worked in a health plan in Colorado and an initiative in Canada. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - collaborative healthcare
KW - SAMHSA
KW - primary care
KW - mental health
KW - integration
KW - Substance Abuse & Mental Health Services Administration
KW - 2008
KW - Drug Abuse
KW - Mental Health
KW - Mental Health Services
KW - Primary Health Care
KW - 2008
DO - 10.1037/a0014233
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18582-008&site=ehost-live&scope=site
UR - tpowers@umassd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00256-007
AN - 2009-00256-007
AU - Jansen, Maria
AU - Harting, Janneke
AU - Ebben, Nicole
AU - Kroon, Bram
AU - Stappers, Jan
AU - Van Engelshoven, Esther
AU - de Vries, Nanne
T1 - The concept of sustainability and the use of outcome indicators. A case study to continue a successful health counseling intervention.
JF - Family Practice
JO - Family Practice
JA - Fam Pract
Y1 - 2008/12//
VL - 25
IS - Suppl1
SP - i32
EP - i37
CY - United Kingdom
PB - Oxford University Press
SN - 0263-2136
SN - 1460-2229
AD - Jansen, Maria, Public Health Service South Limburg Management, PO Box 2022, 6160, Geleen, Netherlands
N1 - Accession Number: 2009-00256-007. Partial author list: First Author & Affiliation: Jansen, Maria; Department of Academic Collaboration for Public Health Limburg, Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands. Release Date: 20090406. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cardiovascular Disorders; Counseling; Health Promotion; Hospitals; Organizational Change. Classification: Inpatient & Hospital Services (3379). Population: Human (10). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Nonclinical Case Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2008.
AB - Background: To ensure the continuation of a successful pilot programme, the change process and the concept of sustainability need to be elaborated. So far, there are different theories on organizational change and sustainability but its practical application stay far behind. Objectives: To test the practical application of a theory-based concept of sustainability and to assess the role of the change agent. A health counselling programme for high-risk cardiovascular patients, called Heartbeat 2, was used as a case study. Methods: Outcome indicators were assessed based on the questions: Why should health counselling be sustained? How should this be done and by whom? How much needs to occur and by when? Data were derived from registrations, reports and focus group interviews. Results: The results indicate a need for a linkage system in the final stages of change so that the programme is maintained. Limitations of the external change agent are described. The outcome indicators appeared to be an adequate operationalization to monitor sustainability. The change process leading up to sustainability appeared to be highly complex due to unpredictable and unforeseen external factors. Conclusions: Our concept of sustainability appeared to be an adequate tool for the change agent to assess the extent of sustainability. An external change agent has limited influence on the management’s decision-making processes during the sustainability stage. As long as the context is changing, definite choices to sustain the innovative service of health counselling in hospitals will not be made, which inherently means an ongoing change process to sustainability. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health counseling intervention
KW - cardiovascular patients
KW - sustainability
KW - change agent
KW - outcome indicators
KW - hospitals
KW - 2008
KW - Cardiovascular Disorders
KW - Counseling
KW - Health Promotion
KW - Hospitals
KW - Organizational Change
KW - 2008
U1 - Sponsor: Netherlands Public Health Care Foundation, Fonds OGZ, Netherlands. Grant: p171. Other Details: Heartbeat 2 study. Recipients: No recipient indicated
DO - 10.1093/fampra/cmn066
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00256-007&site=ehost-live&scope=site
UR - maria.jansen@ggdzl.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17553-001
AN - 2008-17553-001
AU - Strine, Tara W.
AU - Mokdad, Ali H.
AU - Balluz, Lina S.
AU - Gonzalez, Olinda
AU - Crider, Raquel
AU - Berry, Joyce T.
AU - Kroenke, Kurt
T1 - Depression and anxiety in the United States: Findings from the 2006 Behavioral Risk Factor Surveillance System.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2008/12//
VL - 59
IS - 12
SP - 1383
EP - 1390
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Strine, Tara W., Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Behavioral Surveillance Branch, 4770 Buford Highway, N.E., Mailstop K-66, Atlanta, GA, US, 30341
N1 - Accession Number: 2008-17553-001. PMID: 19033164 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Strine, Tara W.; Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Behavioral Surveillance Branch, Atlanta, GA, US. Release Date: 20090323. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Kroenke, Kurt. Major Descriptor: Anxiety; Chronic Illness; Epidemiology; Major Depression; Obesity. Minor Descriptor: Health Behavior; Risk Perception. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Behavioral Risk Factor Surveillance Survey; Patient Health Questionnaire DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2008.
AB - Objective: This study examined the unadjusted and adjusted prevalence estimates of depression and anxiety at the state level and examined the odds ratios of depression and anxiety for selected risk behaviors, obesity, and chronic diseases. Methods: The 2006 Behavioral Risk Factor Surveillance Survey, a random-digit-dialed telephone survey, collected depression and anxiety data from 217,379 participants in 38 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. Current depressive symptoms were assessed with the standardized and validated eight-item Patient Health Questionnaire, and lifetime diagnosis of depression and anxiety was assessed by two additional questions (one question for each diagnosis). Results: The overall prevalence of current depressive symptoms was 8.7% (range by state and territory, 5.3%–13.7%); of a lifetime diagnosis of depression, 15.7% (range, 6.8%–21.3%); and of a lifetime diagnosis of anxiety, 11.3% (range, 5.4%–17.2%). After sociodemographic characteristics, adverse health behaviors, and chronic illnesses were adjusted for, cardiovascular disease, diabetes, asthma, smoking, and obesity were all significantly associated with current depressive symptoms, a lifetime diagnosis of anxiety, and a lifetime diagnosis of depression. Physically inactive adults were significantly more likely than those who were physically active to have current depressive symptoms or a lifetime diagnosis of depression, whereas those who drank heavily were significantly more likely than those who did not to have current depressive symptoms or a lifetime diagnosis of anxiety. Conclusions: Depression and anxiety were strongly associated with common chronic medical disorders and adverse health behaviors. Examination of mental health should therefore be an integral component of overall health care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - anxiety
KW - US
KW - prevalence
KW - risk behavior
KW - obesity
KW - chronic diseases
KW - health behavior
KW - 2008
KW - Anxiety
KW - Chronic Illness
KW - Epidemiology
KW - Major Depression
KW - Obesity
KW - Health Behavior
KW - Risk Perception
KW - 2008
U1 - Sponsor: Soponsor Name Not Included. Recipients: Kroenke, Kurt
DO - 10.1176/appi.ps.59.12.1383
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17553-001&site=ehost-live&scope=site
UR - tws2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18844-003
AN - 2008-18844-003
AU - Chiou, Sharon S.
AU - Pan, Christopher S.
AU - Bhattacharya, Amit
T1 - Kinematics and kinetics of gait on stilts: Identification of risk factors associated with construction stilt use.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2008/12//
VL - 51
IS - 12
SP - 1814
EP - 1829
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Chiou, Sharon S., Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2008-18844-003. PMID: 18608480 Partial author list: First Author & Affiliation: Chiou, Sharon S.; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20090202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Motor Processes; Risk Factors; Gait. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Dec, 2008.
AB - This study investigated kinematics and kinetic strategies and identified risk factors associated with gait on stilts. A six-camera motion-analysis system and two force platforms were used to test 20 construction workers for straight walking or turning, with or without carrying tools while wearing safety shoes or stilts at different heights. The results indicated that gait on stilts is characterised by increases in stride length, step width and the percentage of double support period, decreases in cadence, minimum foot clearance and a weaker heel-strike and push-off. Stilts place greater joint loadings on lower extremities to compensate for the added weight and limitation in joint mobility. Smaller foot clearances found for gait on stilts constitute an increased risk for tripping over obstacles. Workers may need to avoid prolonged use of stilts to alleviate stresses on the joints. This study was conducted to determine to what extent stilts alter the gait strategies and to explain the compensatory movements. Prior to this study, there has been little substantive research to evaluate the stresses and potential injuries associated with stilts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - kinematics
KW - kinetics
KW - gait on stilts
KW - risk factors
KW - construction stilt use
KW - motion analysis
KW - 2008
KW - Human Factors Engineering
KW - Motor Processes
KW - Risk Factors
KW - Gait
KW - 2008
DO - 10.1080/00140130801961885
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18844-003&site=ehost-live&scope=site
UR - schiou@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18844-008
AN - 2008-18844-008
AU - Simeonov, Peter
AU - Hsiao, Hongwei
AU - Powers, John
AU - Ammons, Douglas
AU - Amendola, Alfred
AU - Kau, Tsui-Ying
AU - Cantis, Douglas
T1 - Footwear effects on walking balance at elevation.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2008/12//
VL - 51
IS - 12
SP - 1885
EP - 1905
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Simeonov, Peter, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2008-18844-008. PMID: 19034784 Partial author list: First Author & Affiliation: Simeonov, Peter; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20090202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Feet (Anatomy); Human Factors Engineering; Virtual Reality; Walking. Minor Descriptor: Blue Collar Workers. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 21. Issue Publication Date: Dec, 2008.
AB - The study evaluated the effects of shoe style on workers' instability during walking at elevation. Twenty-four construction workers performed walking tasks on roof planks in a surround-screen virtual reality system, which simulated a residential roof environment. Three common athletic and three work shoe styles were tested on wide, narrow and tilted planks on a simulated roof and on an unrestricted surface at simulated ground. Dependent variables included lateral angular velocities of the trunk and the rear foot, as well as the workers' rated perceptions of instability. The results demonstrated that shoe style significantly affected workers walking instability at elevated work environments. The results highlighted two major shoe-design pathways for improving walking balance at elevation: enhancing rear foot motion control; and improving ankle proprioception. This study also outlined some of the challenges in optimal shoe selection and specific shoe-design needs for improved walking stability during roof work. The study adds to the knowledge in the area of balance control, by emphasising the role of footwear as a critical human-support surface interface during work on narrow surfaces at height. The results can be used for footwear selection and improvements to reduce risk of falls from elevation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - footwear effects
KW - walking balance at elevation
KW - virtual reality
KW - construction workers
KW - 2008
KW - Feet (Anatomy)
KW - Human Factors Engineering
KW - Virtual Reality
KW - Walking
KW - Blue Collar Workers
KW - 2008
DO - 10.1080/00140130802562625
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18844-008&site=ehost-live&scope=site
UR - psimeonov@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18844-009
AN - 2008-18844-009
AU - Bell, Jennifer L.
AU - Collins, James W.
AU - Wolf, Laurie
AU - Grönqvist, Raoul
AU - Chiou, Sharon
AU - Chang, Wen-Ruey
AU - Sorock, Gary S.
AU - Courtney, Theodore K.
AU - Lombardi, David A.
AU - Evanoff, Bradley
T1 - Evaluation of a comprehensive slip, trip and fall prevention programme for hospital employees.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2008/12//
VL - 51
IS - 12
SP - 1906
EP - 1925
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Bell, Jennifer L., Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV, US, 26505-2888
N1 - Accession Number: 2008-18844-009. PMID: 18932056 Partial author list: First Author & Affiliation: Bell, Jennifer L.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, US. Release Date: 20090202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: IEA International Conference on Slips, Trips and Falls, 2007. Conference Note: Preliminary results from this study were previously presented in brief at the aforementioned conference. Major Descriptor: Falls; Prevention; Program Evaluation; Health Personnel. Minor Descriptor: Hospitals; Injuries. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Dec, 2008.
AB - In 2007, the Bureau of Labor Statistics reported that the incidence rate of lost workday injuries from slips, trips and falls (STFs) on the same level in hospitals was 35.2 per 10,000 full-time equivalents (FTE), which was 75% greater than the average rate for all other private industries combined (20.2 per 10,000 FTEs). The objectives of this 10-year (1996-2005) longitudinal study were to: 1) describe occupational STF injury events in hospitals; 2) evaluate the effectiveness of a comprehensive programme for reducing STF incidents among hospital employees. The comprehensive prevention programme included analysis of injury records to identify common causes of STFs, on-site hazard assessments, changes to housekeeping procedures and products, introduction of STF preventive products and procedures, general awareness campaigns, programmes for external ice and snow removal, flooring changes and slip-resistant footwear for certain employee subgroups. The hospitals' total STF workers' compensation claims rate declined by 58% from the pre-intervention (1996-1999) rate of 1.66 claims per 100 FTE to the post-intervention (2003-2005) time period rate of 0.76 claims per 100 FTE (adjusted rate ratio = 0.42, 95% CI: 0.33-0.54). STFs due to liquid contamination (water, fluid, slippery, greasy and slick spots) were the most common cause (24%) of STF claims for the entire study period 1996-2005. Food services, transport/emergency medical service and housekeeping staff were at highest risk of a STF claim in the hospital environment. Nursing and office administrative staff generated the largest numbers of STF claims. STF injury events in hospitals have a myriad of causes and the work conditions in hospitals are diverse. This research provides evidence that implementation of a broad-scale prevention programme can significantly reduce STF injury claims. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fall prevention program
KW - hospital employees
KW - injuries
KW - 2008
KW - Falls
KW - Prevention
KW - Program Evaluation
KW - Health Personnel
KW - Hospitals
KW - Injuries
KW - 2008
DO - 10.1080/00140130802248092
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18844-009&site=ehost-live&scope=site
UR - ORCID: 0000-0003-0116-1386
UR -
UR - JBell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16516-005
AN - 2008-16516-005
AU - Mutter, Ryan L.
AU - Rosko, Michael D.
AU - Wong, Herbert S.
T1 - Measuring hospital inefficiency: The effects of controlling for quality and patient burden of illness.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2008/12//
VL - 43
IS - 6
SP - 1992
EP - 2013
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - Mutter, Ryan L., Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD, US
N1 - Accession Number: 2008-16516-005. PMID: 18783458 Partial author list: First Author & Affiliation: Mutter, Ryan L.; Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Rosko, Michael D. Major Descriptor: Disabilities; Hospitals; Quality of Care. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Internet; Tables and Figures Internet. References Available: Y. Page Count: 22. Issue Publication Date: Dec, 2008. Copyright Statement: Health Research and Educational Trust
AB - Objective: To assess the impact of employing a variety of controls for hospital quality and patient burden of illness on the mean estimated inefficiency and relative ranking of hospitals generated by stochastic frontier analysis (SFA). Study Setting: This study included urban U.S. hospitals in 20 states operating in 2001. Data Design/Data Collection: We took hospital data for 1,290 hospitals from the American Hospital Association Annual Survey and the Medicare Cost Reports. We employed a variety of controls for hospital quality and patient burden of illness. Among the variables we used were a subset of the quality indicators generated from the application of the Patient Safety Indicator and Inpatient Quality Indicator modules of the Agency for Healthcare Research and Quality, Quality Indicator software to the Healthcare Cost and Utilization Project (HCUP), State Inpatient Databases. Measures of a component of patient burden of illness came from the application of the Comorbidity Software to HCUP data. Data Analysis: We used SFA to estimate hospital cost-inefficiency. We tested key assumptions of the SFA model with likelihood ratio tests. Principal Findings: The measures produced by the Comorbidity Software appear to account for variations in patient burden of illness that had previously been masquerading as inefficiency. Outcome measures of quality can provide useful insight into a hospital's operations but may have little impact on estimated inefficiency once controls for structural quality and patient burden of illness have been employed. Conclusions: Choices about controlling for quality and patient burden of illness can have a nontrivial impact on mean estimated hospital inefficiency and the relative ranking of hospitals generated by SFA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hospital quality
KW - quality control
KW - burden of illness
KW - hospitals
KW - 2008
KW - Disabilities
KW - Hospitals
KW - Quality of Care
KW - 2008
U1 - Sponsor: Widener University, School of Business Administration, US. Other Details: Dean’s Summer Grant. Recipients: Rosko, Michael D.
DO - 10.1111/j.1475-6773.2008.00892.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16516-005&site=ehost-live&scope=site
UR - rmutter@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17808-016
AN - 2008-17808-016
AU - Korthuis, P. Todd
AU - Saha, Somnath
AU - Fleishman, John A.
AU - McGrath, Moriah McSharry
AU - Josephs, Joshua S.
AU - Moore, Richard D.
AU - Gebo, Kelly A.
AU - Hellinger, James
AU - Beach, Mary Catherine
T1 - Impact of patient race on patient experiences of access and communication in HIV care.
JF - Journal of General Internal Medicine
JO - Journal of General Internal Medicine
JA - J Gen Intern Med
Y1 - 2008/12//
VL - 23
IS - 12
SP - 2046
EP - 2052
CY - Germany
PB - Springer
SN - 0884-8734
SN - 1525-1497
AD - Korthuis, P. Todd, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Mail Code L-475, Portland, OR, US, 97239-3098
N1 - Accession Number: 2008-17808-016. PMID: 18830770 Partial author list: First Author & Affiliation: Korthuis, P. Todd; Department of Medicine, Oregon Health and Science University, Portland, OR, US. Institutional Authors: HIV Research Network. Other Publishers: Blackwell Publishing. Release Date: 20091109. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Society of General Internal Medicine meeting, 30th, Apr, 2007, Toronto, ON, Canada. Grant Information: Korthuis, P. Todd. Conference Note: Preliminary results were presented as an oral abstract at the aforementioned conference. Major Descriptor: Client Attitudes; Experiences (Events); Health Care Utilization; HIV; Racial and Ethnic Differences. Minor Descriptor: Communication. Classification: Immunological Disorders (3291); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Consumer Assessment of Healthcare Providers and Systems Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2008. Publication History: First Posted Date: Oct 2, 2008; Accepted Date: Aug 27, 2008; Revised Date: Aug 11, 2008; First Submitted Date: Apr 19, 2008. Copyright Statement: Society of General Internal Medicine. 2008.
AB - Background: Patient-centered care—including the domains of access and communication—is an important determinant of positive clinical outcomes. Objective: To explore associations between race and HIV-infected patients’ experiences of access and communication. Design: This was a cross-sectional survey. Participants: Nine hundred and fifteen HIV-infected adults receiving care at 14 U.S. HIV clinics. Measurements: Dependent variables included patients’ reports of travel time to their HIV care site and waiting time to see their HIV provider (access) and ratings of their HIV providers on always listening, explaining, showing respect, and spending enough time with them (communication). We used multivariate logistic regression to estimate associations between patient race and dependent variables, and random effects models to estimate site-level contributions. Results: Patients traveled a median 30 minutes (range 1–180) and waited a median 20 minutes (range 0–210) to see their provider. On average, blacks and Hispanics reported longer travel and wait times compared with whites. Adjusting for HIV care site attenuated this association. HIV care sites that provide services to a greater proportion of blacks and Hispanics may be more difficult to access for all patients. The majority of patients rated provider communication favorably. Compared to whites, blacks reported more positive experiences with provider communication. Conclusions: We observed racial disparities in patients’ experience of access to care but not in patient–provider communication. Disparities were explained by poor access at minority-serving clinics. Efforts to make care more patient-centered for minority HIV-infected patients should focus more on improving access to HIV care in minority communities than on improving cross-cultural patient–provider interactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient race
KW - patient experiences
KW - health care access
KW - communication
KW - HIV care
KW - 2008
KW - Client Attitudes
KW - Experiences (Events)
KW - Health Care Utilization
KW - HIV
KW - Racial and Ethnic Differences
KW - Communication
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290–01–0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: K23- DA019809. Recipients: Korthuis, P. Todd
U1 - Sponsor: US Department of Veterans Affairs, Health Services Research & Development Service, US. Other Details: Advanced Research Career Development Award. Recipients: Saha, Somnath
U1 - Sponsor: Robert Wood Johnson Foundation. Other Details: Generalist Physician Faculty Scholar Award. Recipients: No recipient indicated
U1 - Sponsor: Johns Hopkins Richard S. Ross Clinician Scientist Award. Recipients: Gebo, Kelly A.
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 1-K08-HS13903. Recipients: Beach, Mary Catherine
DO - 10.1007/s11606-008-0788-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17808-016&site=ehost-live&scope=site
UR - korthuis@ohsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16516-009
AN - 2008-16516-009
AU - Encinosa, William E.
AU - Hellinger, Fred J.
T1 - The impact of medical errors on ninety-day costs and outcomes: An examination of surgical patients.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2008/12//
VL - 43
IS - 6
SP - 2067
EP - 2085
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - Encinosa, William E., Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2008-16516-009. PMID: 18662169 Partial author list: First Author & Affiliation: Encinosa, William E.; Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Errors; Health Care Costs; Hospital Admission; Surgery. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Internet. References Available: Y. Page Count: 19. Issue Publication Date: Dec, 2008. Copyright Statement: Health Research and Educational Trust
AB - Objective: To estimate the effect of medical errors on medical expenditures, death, readmissions, and outpatient care within 90 days after surgery. Data Sources: 2001–2002 MarketScan insurance claims for 5.6 million enrollees. Study Design: The Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) were used to identify 14 PSIs among 161,004 surgeries. We used propensity score matching and multivariate regression analyses to predict expenditures and outcomes attributable to the 14 PSIs. Principal Findings: Excess 90-day expenditures likely attributable to PSIs ranged from $646 for technical problems (accidental laceration, pneumothorax, etc.) to $28,218 for acute respiratory failure, with up to 20 percent of these costs incurred postdischarge. With a third of all 90-day deaths occurring postdischarge, the excess death rate associated with PSIs ranged from 0 to 7 percent. The excess 90-day readmission rate associated with PSIs ranged from 0 to 8 percent. Overall, 11 percent of all deaths, 2 percent of readmissions, and 2 percent of expenditures were likely due to these 14 PSIs. Conclusions: The effects of medical errors continue long after the patient leaves the hospital. Medical error studies that focus only on the inpatient stay can underestimate the impact of patient safety events by up to 20–30 percent. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical errors
KW - medical expenditures
KW - death
KW - readmissions
KW - outpatient care
KW - surgery
KW - 2008
KW - Death and Dying
KW - Errors
KW - Health Care Costs
KW - Hospital Admission
KW - Surgery
KW - 2008
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1111/j.1475-6773.2008.00882.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16516-009&site=ehost-live&scope=site
UR - william.encinosa@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-16544-010
AN - 2008-16544-010
AU - Berdahl, Terceira A.
T1 - Racial/ethnic and gender differences in individual workplace injury risk trajectories: 1988-1998.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2008/12//
VL - 98
IS - 12
SP - 2258
EP - 2263
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Berdahl, Terceira A., Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2008-16544-010. PMID: 18235072 Partial author list: First Author & Affiliation: Berdahl, Terceira A.; Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diversity in the Workplace; Human Sex Differences; Injuries; Racial and Ethnic Differences; Risk Factors. Minor Descriptor: Occupational Mobility; Occupations. Classification: Industrial & Organizational Psychology (3600). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2008. Publication History: Accepted Date: Jun 22, 2007.
AB - Objectives: I examined workplace injury risk over time and across racial/ethnic and gender groups to observe patterns of change and to understand how occupational characteristics and job mobility influence these changes. Methods: I used hierarchical generalized linear models to estimate individual work place injury and illness risk over time ('trajectories') for a cohort of American workers who participated in the National Longitudinal Survey of Youth (1988–1998). Results: Significant temporal variation in injury risk was observed across racial/ethnic and gender groups. At baseline, White men had a high risk of injury relative to the other groups and experienced the greatest decline over time. Latino men demonstrated a pattern of lower injury risk across time compared with White men. Among both Latinos and non-Latino Whites, women had lower odds of injury than did men. Non-Latino Black women’s injury risk was similar to Blackmen’s and greater than that for both Latino and non-Latino White women. Occupational characteristics and job mobility partly explained these differences. Conclusions: Disparities between racial/ethnic and gender groups were dynamic and changed over time. Work place injury risk was associated with job dimensions such as work schedule, union representation, health insurance, job hours, occupational racial segregation, and occupational environmental hazards. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial and ethnic differences
KW - gender differences
KW - workplace injury risk trajectories
KW - occupational characteristics
KW - job mobility
KW - 2008
KW - Diversity in the Workplace
KW - Human Sex Differences
KW - Injuries
KW - Racial and Ethnic Differences
KW - Risk Factors
KW - Occupational Mobility
KW - Occupations
KW - 2008
U1 - Sponsor: Bureau of Labor Statistics, US. Other Details: National Longitudinal Survey of Youth. Recipients: No recipient indicated
U1 - Sponsor: Ohio State University, Center for Human Resource Research, US. Other Details: National Longitudinal Survey of Youth. Recipients: No recipient indicated
DO - 10.2105/AJPH.2006.103135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-16544-010&site=ehost-live&scope=site
UR - terceira.berdahl@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-00479-002
AN - 2010-00479-002
AU - Kogan, Michael D.
AU - Strickland, Bonnie B.
AU - Blumberg, Stephen J.
AU - Singh, Gopal K.
AU - Perrin, James M.
AU - van Dyck, Peter C.
T1 - A national profile of the health care experiences and family impact of autism spectrum disorder among children in the United States, 2005–2006.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2008/12//
VL - 122
IS - 6
SP - e1149
EP - e1158
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Kogan, Michael D., Maternal and Child Health Bureau, Health Resources and Services Administration, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2010-00479-002. PMID: 19047216 Partial author list: First Author & Affiliation: Kogan, Michael D.; Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, US. Release Date: 20101122. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Autism Spectrum Disorders; Family; Health Care Services; Home Care. Classification: Developmental Disorders & Autism (3250); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Dec, 2008. Publication History: Accepted Date: Aug 19, 2008. Copyright Statement: American Academy of Pediatrics. 2008.
AB - Objectives: We sought to examine the health care experiences of children with autism spectrum disorder and the impact of autism spectrum disorder on the family and to assess whether having a medical home is associated with less family impact. Methods: We used the 2005–2006 National Survey of Children With Special Health Care Needs to compare 2088 children with special health care needs, aged 3 to 17 years, reported by their parents to have autism spectrum disorder, with children with special health care needs with 'other emotional, developmental, or behavioral problems' (excluding autism spectrum disorder; n = 9534) and 26751 other children with special health care needs. We used weighted logistic regression to examine unmet needs for specific health care and support services, delayed care, no usual care source or personal physician, difficulty receiving referrals, and financial, employment, or time problems because of child's care. Results: Nationally, an estimated 535000 children have special health care needs and autism spectrum disorder, a prevalence of 86 per 10000 children aged 3 to 17 years. Among children with special health care needs, 5.6% have autism spectrum disorder. Compared with other children with special health care needs without emotional, developmental, or behavioral problems, children with special health care needs with autism spectrum disorder were more likely to have unmet needs for specific health care services, family support services, delayed or foregone care, difficulty receiving referrals, and care that is not family centered. Children with special health care needs with autism spectrum disorder were more likely to live in families that report financial problems, need additional income for the child's medical care, reduce or stop work because of the child's condition, spend ≥10 hours per week providing or coordinating care, and paid more than $1000 in the previous year for the child's care. The financial impacts of autism spectrum disorder were significantly more burdensome when children with special health care needs did not have a medical home. Conclusions: Children with special health care needs with autism spectrum disorder are significantly more likely to have problems regarding access to care and unmet needs, and their families have greater financial, employment, and time burdens compared with other children with special health care needs. Receipt of primary care in a medical home may reduce these burdens. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care experiences
KW - family
KW - children with autism spectrum disorder
KW - medical homes
KW - family impact
KW - 2008
KW - Autism Spectrum Disorders
KW - Family
KW - Health Care Services
KW - Home Care
KW - 2008
DO - 10.1542/peds.2008-1057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-00479-002&site=ehost-live&scope=site
UR - mkogan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Higgins, K.
AU - Singer, M.
AU - Valappil, T.
AU - Nambiar, S.
AU - Lin, D.
AU - Cox, E.
T1 - Overview of Recent Studies of Community-Acquired Pneumonia.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/12/02/12/1/2008 Supplement 3
VL - 47
M3 - Article
SP - S150
EP - S156
SN - 10584838
AB - All recent studies of antibacterial drugs for the indication of community-acquired pneumonia submitted to the US Food and Drug Administration have been designed as noninferiority studies. We provide a summary of results of 7 recent clinical studies of oral antibacterial drugs for treatment of community-acquired pneumonia. In these 7 studies, the majority of patients enrolled had Pneumonia Patient Outcomes Research Team scores of I or II. The percentage of randomized subjects with pathogens identified at baseline ranged from 47% to 76%, and the percentage of subjects with Streptoccocus pneumonia isolated at baseline ranged from -6% to 20%. The primary end point in these studies was clinical cure, assessed 7-21 days after completion of therapy. Clinical cure rates were >80% in the intent-to-treat populations and >90% in the per-protocol populations. We also briefly summarize the results from several recently submitted clinical studies of intra- venously administered antibacterial drugs for treatment of community-acquired pneumonia, in which we found similar results. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Community-acquired pneumonia
KW - Lung diseases
KW - Clinical trials
KW - Pneumonia -- Treatment
KW - United States. Food & Drug Administration
N1 - Accession Number: 35966277; Higgins, K. 1; Email Address: karenhiggins@fda.hhs.gov; Singer, M. 1; Valappil, T. 1; Nambiar, S. 1; Lin, D. 1; Cox, E. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland; Issue Info: 12/1/2008 Supplement 3, Vol. 47, pS150; Thesaurus Term: Antibacterial agents; Subject Term: Community-acquired pneumonia; Subject Term: Lung diseases; Subject Term: Clinical trials; Subject Term: Pneumonia -- Treatment ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1086/591397
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35966277&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Singer, M.
AU - Nambiar, S.
AU - Valappil, T.
AU - Higgins, K.
AU - Gitterman, S.
T1 - Historical and Regulatory Perspectives on the Treatment Effect of Antibacterial Drugs for Community-Acquired Pneumonia.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/12/02/12/1/2008 Supplement 3
VL - 47
M3 - Article
SP - S216
EP - S224
SN - 10584838
AB - A noninferiority margin based on the treatment effect of antibacterial drugs is required for noninferiority studies of community-acquired pneumonia. A quantitative estimate of treatment effect is generally determined from placebo-controlled trials, but, since the mid-to-late 1930s, no studies have compared outcomes for patients who received placebo (or no specific therapy) with those for patients who received an antibacterial drug for treatment of community-acquired pneumonia. In this article, early controlled studies, as well as observational data, are reviewed, and the beneficial effect of antibacterial drugs on mortality rates among patients with pneumococcal pneumonia is demonstrated. However, because these data were obtained in the early 20th century, several important factors have changed, including patient populations, the etiological agents of pneumonia, and medical standards of care. Thus, the applicability of these studies to the determination of a noninferiority margin for contemporary trials for community-acquired pneumonia remains in question. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Antibacterial agents
KW - Community-acquired pneumonia
KW - Clinical trials
KW - Medical experimentation on humans
KW - Pneumonia -- Treatment
KW - Outcome assessment (Medical care)
N1 - Accession Number: 35966288; Singer, M. 1; Email Address: mary.singer@fda.hhs.gov; Nambiar, S. 1; Valappil, T. 1; Higgins, K. 1; Gitterman, S. 1; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Office of Antimicrobial Products, Silver Spring, Maryland; Issue Info: 12/1/2008 Supplement 3, Vol. 47, pS216; Thesaurus Term: Antibacterial agents; Subject Term: Community-acquired pneumonia; Subject Term: Clinical trials; Subject Term: Medical experimentation on humans; Subject Term: Pneumonia -- Treatment; Subject Term: Outcome assessment (Medical care); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1086/591407
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Settle, T.
AU - Moritz, J.
AU - Leonard, S.
AU - Falkenstein, E.
AU - Klandorf, H.
T1 - The effects of a phytogenic feed additive versus an antibiotic feed additive on oxidative stress in broiler chicks and electron spin resonance.
JO - Poultry Science
JF - Poultry Science
Y1 - 2008/12/02/2008 Supplement 1
VL - 87
M3 - Abstract
SP - 116
EP - 116
SN - 00325791
AB - The article presents an abstract of the research paper "The effects of a phytogenic feed additive versus an antibiotic feed additive on oxidative stress in broiler chicks and electron spin resonance," by T. Settle and colleagues.
KW - BROILERS (Chickens)
KW - ABSTRACTS
KW - electron spin resonance
KW - oxidative stress
KW - phytogenic additive
N1 - Accession Number: 36310023; Settle, T. 1 Moritz, J. 1 Leonard, S. 2 Falkenstein, E. 1 Klandorf, H. 1; Affiliation: 1: West Virginia University, Morgantown. 2: National Institute of Occupational Safety and Health and Centers for Disease Control, Morgantown, West Virginia.; Source Info: 2008 Supplement 1, Vol. 87, p116; Subject Term: BROILERS (Chickens); Subject Term: ABSTRACTS; Author-Supplied Keyword: electron spin resonance; Author-Supplied Keyword: oxidative stress; Author-Supplied Keyword: phytogenic additive; NAICS/Industry Codes: 112320 Broilers and Other Meat Type Chicken Production; Number of Pages: 1/4p; Document Type: Abstract
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Floyd, R. Louise
AU - Jack, Brian W.
AU - Cefalo, Robert
AU - Atrash, Hani
AU - Mahoney, Jeanne
AU - Herron, Anne
AU - Husten, Corinne
AU - Sokol, Robert J.
T1 - The clinical content of preconception care: alcohol, tobacco, and illicit drug exposures
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2008/12/03/Dec2008 Supplement B
VL - 199
IS - s6
M3 - Article
SP - S333
EP - S339
SN - 00029378
AB - Substance abuse poses significant health risks to childbearing-aged women in the United States and, for those who become pregnant, to their children. Alcohol is the most prevalent substance consumed by childbearing-aged women, followed by tobacco, and a variety of illicit drugs. Substance use in the preconception period predicts substance use during the prenatal period. Evidence-based methods for screening and intervening on harmful consumption patterns of these substances have been developed and are recommended for use in primary care settings for women who are pregnant, planning a pregnancy, or at risk for becoming pregnant. This report describes the scope of substance abuse in the target population and provides recommendations from the Clinical Working Group of the Select Panel on Preconception Care, Centers for Disease Control and Prevention, for addressing alcohol, tobacco, and illicit drug use among childbearing-aged women. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRECONCEPTION care
KW - DRUGS of abuse
KW - SUBSTANCE abuse in pregnancy
KW - PRENATAL care
KW - PREGNANCY complications
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States
KW - alcohol
KW - preconception
KW - substance abuse
KW - women
N1 - Accession Number: 35722610; Floyd, R. Louise 1; Email Address: rlf3@cdc.gov; Jack, Brian W. 2; Cefalo, Robert 3; Atrash, Hani 1; Mahoney, Jeanne 4; Herron, Anne 5; Husten, Corinne 6; Sokol, Robert J. 7; Source Information: Dec2008 Supplement B, Vol. 199 Issue s6, pS333; Subject: PRECONCEPTION care; Subject: DRUGS of abuse; Subject: SUBSTANCE abuse in pregnancy; Subject: PRENATAL care; Subject: PREGNANCY complications; Subject: CENTERS for Disease Control & Prevention (U.S.); Geographic Terms: UNITED States; Author-Supplied Keyword: alcohol; Author-Supplied Keyword: preconception; Author-Supplied Keyword: substance abuse; Author-Supplied Keyword: women; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.ajog.2008.09.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=35722610&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Cierpich, H.
AU - Styles, L.
AU - Harrison, R.
AU - Davis, L.
AU - Chester, D.
AU - Lefkowitz, D.
AU - Valiante, D.
AU - Richardson, S.
AU - Castillo, D.
AU - Romano, N.
AU - Baron, S.
T1 - Work-Related Injury Deaths Among Hispanics--United States, 1992-2006.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2008/12/03/
VL - 300
IS - 21
M3 - Article
SP - 2479
EP - 2480
SN - 00987484
AB - The article summarizes the results of an analysis by the U.S. Centers for Disease Control and Prevention, the Bureau of Labor Statistics, and state agencies which characterized work-related injury deaths among Hispanic workers in the U.S. The death rate was found to decrease during 1992-2006 but was higher than the rate for all U.S. workers. The proportion of deaths among foreign-born Hispanic workers increased over time. The most common industries employing Hispanics who died from work related injuries during 2003-2006 included construction and administrative and waste services.
KW - HISPANIC Americans
KW - MORTALITY -- Statistics
KW - WORK-related injuries
KW - OCCUPATIONAL mortality
KW - CONSTRUCTION workers
KW - ACCIDENTS
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
KW - UNITED States. Bureau of Labor Statistics
N1 - Accession Number: 35536199; Cierpich, H. 1 Styles, L. 1 Harrison, R. 2 Davis, L. 3 Chester, D. 4 Lefkowitz, D. 5 Valiante, D. 5 Richardson, S. 6 Castillo, D. 7 Romano, N. 7 Baron, S. 7; Affiliation: 1: Public Health Institute. Oakland 2: Occupational Health ßr, California Dept of Public Health. 3: Occupational Surveillance Program, Massachusetts Dept of Public Health. 4: Michigan State Univ. 5: New Jersey Deot of Health and Senior Svcs. 6: Bur of Labor Statistics, US Dept of Labor. 7: National Institute for Occupational Safety and Health, CDC.; Source Info: 12/3/2008, Vol. 300 Issue 21, p2479; Subject Term: HISPANIC Americans; Subject Term: MORTALITY -- Statistics; Subject Term: WORK-related injuries; Subject Term: OCCUPATIONAL mortality; Subject Term: CONSTRUCTION workers; Subject Term: ACCIDENTS; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.) Company/Entity: UNITED States. Bureau of Labor Statistics; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 926110 Administration of General Economic Programs; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chiesa, Roberto
AU - Piccardo, Pedro
AU - Biasini, Emiliano
AU - Ghetti, Bernardino
AU - Harris, David A.
T1 - Aggregated, Wild-Type Prion Protein Causes Neurological Dysfunction and Synaptic Abnormalities.
JO - Journal of Neuroscience
JF - Journal of Neuroscience
Y1 - 2008/12/03/
VL - 28
IS - 49
M3 - Article
SP - 13258
EP - 13267
SN - 02706474
AB - The neurotoxic forms of the prion protein (PrP) that cause neurodegeneration in prion diseases remain to be conclusively identified. Considerable evidence points to the importance of noninfectious oligomers of PrP in the pathogenic process. In this study, we describe lines of Tg(WT) transgenic mice that over-express wild-type PrP by either ∼5-fold or ∼10-fold (depending on whether the transgene array is, respectively, hemizygous or homozygous). Homozygous but not hemizygous Tg(WT) mice develop a spontaneous neurodegenerative illness characterized clinically by tremor and paresis. Both kinds of mice accumulate large numbers of punctate PrP deposits in the molecular layer of the cerebellum as well as in several other brain regions, and they display abnormally enlarged synaptic terminals accompanied by a dramatic proliferation ofmembranousstructures. The over-expressed PrP in Tg(WT) mice assembles into an insoluble form that is mildly protease-resistant and is recognizable by aggregation-specific antibodies, but that is not infectious in transmission experiments. Together, our results demonstrate that noninfectious aggregates of wild-type PrP are neurotoxic, particularly to synapses, and they suggest common pathogenic mechanisms shared by prion diseases and nontransmissible neurodegenerative disorders associated with protein misfolding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Neuroscience is the property of Society for Neuroscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIONS
KW - PRION diseases
KW - PRION diseases in animals
KW - NEURAL transmission
KW - NEURODEGENERATION
KW - TRANSGENIC mice
KW - NEUROLOGIC manifestations of general diseases
KW - neurodegeneration
KW - prion
KW - protein aggregation
KW - synapse
KW - transgenic
KW - wild-type
N1 - Accession Number: 35598161; Chiesa, Roberto 1 Piccardo, Pedro 2,3 Biasini, Emiliano 1,4 Ghetti, Bernardino 2 Harris, David A. 4; Email Address: dharris@wustl.edu; Affiliation: 1: Dulbecco Telethon Institute and Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milan, Italy 2: Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852 4: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110; Source Info: 12/3/2008, Vol. 28 Issue 49, p13258; Subject Term: PRIONS; Subject Term: PRION diseases; Subject Term: PRION diseases in animals; Subject Term: NEURAL transmission; Subject Term: NEURODEGENERATION; Subject Term: TRANSGENIC mice; Subject Term: NEUROLOGIC manifestations of general diseases; Author-Supplied Keyword: neurodegeneration; Author-Supplied Keyword: prion; Author-Supplied Keyword: protein aggregation; Author-Supplied Keyword: synapse; Author-Supplied Keyword: transgenic; Author-Supplied Keyword: wild-type; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 8 Graphs; Document Type: Article
L3 - 10.1523/JNEUROSCI.3109-08.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Angyal, G.
AU - Csepura, G.
AU - Balkay, L.
AU - Galuska, L.
AU - Molnár, J.
AU - Valastyán, I.
T1 - PET examination in intracranial tumor diagnosis of a cat.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2008/12/08/
VL - 1080
IS - 1
M3 - Article
SP - 199
EP - 203
PB - American Institute of Physics
SN - 0094243X
AB - This paper shows the significance of the Positron Emission Tomography (PET) in the veterinary medication through a case study of a cat brain tumor. A castrated male cat with bilateral mydriasis and blindness arrived at the veterinary clinic. After physical, laboratory and neurological investigations other sickness was ruled out and the inkling of the intracranial lesion had come to light. Brain tumor seemed the most likely to cause the illness because other symptoms appeared (for example: anorexia, depression) and they progrediated fast. PET examination, using 18F-FDG isotope, was performed to confirm the possible causes of the cat’s symptoms [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMISSION tomography
KW - POSITRON emission
KW - VETERINARY medicine
KW - TUMORS -- Diagnosis
KW - CATS -- Diseases
KW - animal PET
KW - PET
KW - tumor diseases
N1 - Accession Number: 35733448; Angyal, G. 1 Csepura, G. 2 Balkay, L. 3 Galuska, L. 3 Molnár, J. 4 Valastyán, I. 4,5; Affiliation: 1: Pavlov’s dog Veterinary Ambulance and Surgeon Center, Debrecen, Hungary 2: Public Health Service, Debrecen, Hungary 3: University Medical School of Debrecen, PET Center, University of Debrecen, Debrecen, Hungary 4: Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary 5: Royal Institute of Technology, Stockholm, Sweden; Source Info: 12/8/2008, Vol. 1080 Issue 1, p199; Subject Term: EMISSION tomography; Subject Term: POSITRON emission; Subject Term: VETERINARY medicine; Subject Term: TUMORS -- Diagnosis; Subject Term: CATS -- Diseases; Author-Supplied Keyword: animal PET; Author-Supplied Keyword: PET; Author-Supplied Keyword: tumor diseases; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 5p; Illustrations: 4 Color Photographs, 3 Diagrams; Document Type: Article
L3 - 10.1063/1.3058982
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Thomas, D. Rh
AU - Chantry, K.
AU - Aubrey, F.
AU - Beaven, S.
AU - Bowen, C.
AU - Fairley, J.
AU - Roberts, A.
AU - Cottrell, S.
AU - Roberts, R.
T1 - Influenza immunisation uptake in carers
JO - Vaccine
JF - Vaccine
Y1 - 2008/12/09/
VL - 26
IS - 52
M3 - Letter
SP - 6746
EP - 6748
SN - 0264410X
AB - Abstract: In 2005 the United Kingdom departments of health added ‘carers’ to the list of people that should be offered seasonal influenza immunisation by their general practice. We surveyed a sample of carers registered for care assistance with the charity Crossroads Caring for Carers. Over half (58%) were not aware that they are eligible for free influenza immunisation. Young carers without a chronic disease, were least likely to be offered immunisation and least likely to be immunised. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Immunization
KW - Influenza
KW - Public health -- Great Britain
KW - Family medicine
KW - Chronic diseases
KW - Medical care
KW - Health surveys
KW - Medicine -- Practice
KW - Great Britain
KW - Carers
KW - Influenza immunisation
KW - Vaccine uptake
KW - Great Britain. Dept. of Health
N1 - Accession Number: 35561580; Thomas, D. Rh 1; Email Address: daniel.thomas@nphs.wales.nhs.uk; Chantry, K. 2; Aubrey, F. 3; Beaven, S. 4; Bowen, C. 5; Fairley, J. 6; Roberts, A. 7; Cottrell, S. 1; Roberts, R. 1; Affiliations: 1: National Public Health Service for Wales, Cardiff, United Kingdom; 2: Rhondda Cynon Taf Crossroads, Pontypridd, United Kingdom; 3: Torfaen Crossroads, Pontypool, United Kingdom; 4: Brecon and Radnorshire Crossroads, Brecon, United Kingdom; 5: Swansea Neath Port Talbot Crossroads, Swansea, United Kingdom; 6: Flintshire Crossroads, Mold, United Kingdom; 7: Crossroads Caring for Carers Wales Office, Cardiff, United Kingdom; Issue Info: Dec2008, Vol. 26 Issue 52, p6746; Thesaurus Term: VACCINATION; Thesaurus Term: Immunization; Subject Term: Influenza; Subject Term: Public health -- Great Britain; Subject Term: Family medicine; Subject Term: Chronic diseases; Subject Term: Medical care; Subject Term: Health surveys; Subject Term: Medicine -- Practice; Subject: Great Britain; Author-Supplied Keyword: Carers; Author-Supplied Keyword: Influenza immunisation; Author-Supplied Keyword: Vaccine uptake ; Company/Entity: Great Britain. Dept. of Health; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.vaccine.2008.09.058
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35561580&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Thomas, D. Rh
AU - Chantry, K.
AU - Aubrey, F.
AU - Beaven, S.
AU - Bowen, C.
AU - Fairley, J.
AU - Roberts, A.
AU - Cottrell, S.
AU - Roberts, R.
T1 - Influenza immunisation uptake in carers
JO - Vaccine
JF - Vaccine
Y1 - 2008/12/09/
VL - 26
IS - 52
M3 - Letter
SP - 6746
EP - 6748
SN - 0264410X
AB - Abstract: In 2005 the United Kingdom departments of health added ‘carers’ to the list of people that should be offered seasonal influenza immunisation by their general practice. We surveyed a sample of carers registered for care assistance with the charity Crossroads Caring for Carers. Over half (58%) were not aware that they are eligible for free influenza immunisation. Young carers without a chronic disease, were least likely to be offered immunisation and least likely to be immunised. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA -- Vaccination
KW - IMMUNIZATION
KW - PUBLIC health
KW - FAMILY medicine
KW - CHRONIC diseases
KW - MEDICAL care
KW - HEALTH surveys
KW - MEDICINE -- Practice
KW - GREAT Britain
KW - Carers
KW - Influenza immunisation
KW - Vaccine uptake
KW - GREAT Britain. Dept. of Health
N1 - Accession Number: 35561580; Thomas, D. Rh 1; Email Address: daniel.thomas@nphs.wales.nhs.uk Chantry, K. 2 Aubrey, F. 3 Beaven, S. 4 Bowen, C. 5 Fairley, J. 6 Roberts, A. 7 Cottrell, S. 1 Roberts, R. 1; Affiliation: 1: National Public Health Service for Wales, Cardiff, United Kingdom 2: Rhondda Cynon Taf Crossroads, Pontypridd, United Kingdom 3: Torfaen Crossroads, Pontypool, United Kingdom 4: Brecon and Radnorshire Crossroads, Brecon, United Kingdom 5: Swansea Neath Port Talbot Crossroads, Swansea, United Kingdom 6: Flintshire Crossroads, Mold, United Kingdom 7: Crossroads Caring for Carers Wales Office, Cardiff, United Kingdom; Source Info: Dec2008, Vol. 26 Issue 52, p6746; Subject Term: INFLUENZA -- Vaccination; Subject Term: IMMUNIZATION; Subject Term: PUBLIC health; Subject Term: FAMILY medicine; Subject Term: CHRONIC diseases; Subject Term: MEDICAL care; Subject Term: HEALTH surveys; Subject Term: MEDICINE -- Practice; Subject Term: GREAT Britain; Author-Supplied Keyword: Carers; Author-Supplied Keyword: Influenza immunisation; Author-Supplied Keyword: Vaccine uptake; Company/Entity: GREAT Britain. Dept. of Health; Number of Pages: 3p; Document Type: Letter
L3 - 10.1016/j.vaccine.2008.09.058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gidudu, Jane
AU - Kohl, Katrin S.
AU - Halperin, Scott
AU - Hammer, Sandra Jo
AU - Heath, Paul T.
AU - Hennig, Renald
AU - Hoet, Bernard
AU - Rothstein, Edward
AU - Schuind, Anne
AU - Varricchio, Frederick
AU - Walop, Wikke
T1 - A local reaction at or near injection site: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
JO - Vaccine
JF - Vaccine
Y1 - 2008/12/09/
VL - 26
IS - 52
M3 - Article
SP - 6800
EP - 6813
SN - 0264410X
AB - Abstract: The need for developing a case definition and guidelines for a local reaction at or near the injection site, methods for the development of the case definition and guidelines as an adverse event following immunization as well as the rationale for selected decisions about the case definition for a local reaction at or near the injection site are explained in the Preamble section. The case definition is structured in 2 levels of diagnostic certainty: level 1 includes any description of morphological or physiological change at or near the injection site that is described or identified by a healthcare provider. Level 2 is any description of morphological or physiological change at or near injection site that is described by any other person. In Guidelines section, the working group recommends to enable meaningful and standardized data collection, analysis, and presentation of information about a local reaction at or near the injection site. However, implementation of all guidelines might not be possible in all settings. The availability of information may vary depending upon resources, geographic region, and whether the source of information is a prospectively designed clinical trial, a post-marketing surveillance or epidemiologic study, or an individual report of a local reaction at injection site. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - Immunization -- Safety measures
KW - Injections
KW - Adverse health care events
KW - Guidelines
KW - Case studies
KW - Clinical trials
KW - Medical care
KW - Medical research
KW - A local reaction
KW - Adverse event
KW - Case definition
KW - Immunization
N1 - Accession Number: 35561589; Gidudu, Jane 1; Email Address: secretariat@brightoncollaboration.org; Kohl, Katrin S. 1; Halperin, Scott 2; Hammer, Sandra Jo 3; Heath, Paul T. 4; Hennig, Renald 5; Hoet, Bernard 6; Rothstein, Edward 7; Schuind, Anne 8; Varricchio, Frederick 9; Walop, Wikke 10; Affiliations: 1: Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop D-26, Atlanta, GA 30333, USA; 2: Dalhousie University, Halifax, Nova Scotia, Canada; 3: California Department of Public Health, Richmond, CA, USA; 4: St George’s University, London, UK; 5: Scratch GbR, Pharmacovigilance Services, Butzbach, Germany; 6: GlaxoSmithKline Biologicals, Rixensart, Belgium; 7: Pennridge Pediatric Associates, Sellersville, PA, USA; 8: GlaxoSmithKline, King of Prussia, PA, USA; 9: Retired, Food and Drug Administration, Rockville, MD, USA; 10: Retired, Public Health Agency of Canada, Ottawa, Ontario, Canada; Issue Info: Dec2008, Vol. 26 Issue 52, p6800; Thesaurus Term: Epidemiology; Subject Term: Immunization -- Safety measures; Subject Term: Injections; Subject Term: Adverse health care events; Subject Term: Guidelines; Subject Term: Case studies; Subject Term: Clinical trials; Subject Term: Medical care; Subject Term: Medical research; Author-Supplied Keyword: A local reaction; Author-Supplied Keyword: Adverse event; Author-Supplied Keyword: Case definition; Author-Supplied Keyword: Immunization; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.10.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xie, Qiang-min
AU - Wu, Ximei
AU - Wu, Hui-min
AU - Deng, Yang-mei
AU - Zhang, Shui-juan
AU - Zhu, Jian-ping
AU - Dong, Xin-wei
T1 - Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats
JO - International Immunopharmacology
JF - International Immunopharmacology
Y1 - 2008/12/10/
VL - 8
IS - 12
M3 - Article
SP - 1639
EP - 1645
SN - 15675769
AB - Abstract: Clinically sublingual immunotherapy (SLIT) by using allergen extracts effectively alleviates the symptoms of allergic rhinitis and asthma. Supposed that oral administration of high-dose of allergen extracts imitates SLIT and may prevent IgE-related responses in allergic diseases, we investigated the effects of oral administration of allergen extracts from Dermatophagoides farinae (Derf) on allergen-induced inflammation and airway hyperresponsiveness (AHR) in a model of asthmatic rat. After administration to the specific Derf-sensitized rats with Derfdrop solution containing Derf1 and Derf2 extracts derived from Derf, the effects of Derfdrop on AHR, inflammatory cell accumulation, cytokine production in the bronchoalveolar lavage fluid and lung tissue, as well as serum IgE and IgG levels were investigated. Results indicated that Derfdrop not only dose-dependently prevented the AHR in response to methacholine, but also significantly reduced the serum total and allergen-specific IgE levels, all the maximal effects were achieved at dose of 5 mg/kg/d, and were as comparable as those of dexamethasone at dose of 1.0 mg/kg/d. Furthermore, oral administration of Derfdrop not only dose-dependently elevated allergen-specific serum IgG levels and reduced total and allergen-specific IgE levels, but also normalized the imbalance between the Th1 cytokine, IFN-γ and Th2 cytokine, IL-4. Finally, oral administration of Derfdrop significantly reduced Goblet cell hyperplasia and eosinophilia in the Derf-sensitized allergic rat model. These data suggest that Derfdrop effectively improves specific allergen-induced inflammation and AHR in Derf-sensitized and -challenged rats and provide with the rationale for clinical SLIT by using Derfdrop in a specific allergen-induced asthma. [Copyright &y& Elsevier]
AB - Copyright of International Immunopharmacology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALLERGENS
KW - DERMATOPHAGOIDES
KW - HOUSE dust mites
KW - HAY fever
KW - ASTHMA
KW - IMMUNOGLOBULIN E
KW - RATS as laboratory animals
KW - THERAPEUTIC use
KW - Airway hyperresponsiveness
KW - Allergen
KW - Asthma
KW - Dermatophagoides farinae
KW - Dust mite
KW - Pulmonary inflammation
N1 - Accession Number: 34650282; Xie, Qiang-min; Email Address: xieqm@zju.edu.cn Wu, Ximei 1 Wu, Hui-min 1 Deng, Yang-mei 1 Zhang, Shui-juan 1 Zhu, Jian-ping 1 Dong, Xin-wei 1; Affiliation: 1: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration, Medical Science College of Zhejiang University, 388 Yuhangtang Rd. Hangzhou City, Zhejiang Province 310058, PR China; Source Info: Dec2008, Vol. 8 Issue 12, p1639; Subject Term: ALLERGENS; Subject Term: DERMATOPHAGOIDES; Subject Term: HOUSE dust mites; Subject Term: HAY fever; Subject Term: ASTHMA; Subject Term: IMMUNOGLOBULIN E; Subject Term: RATS as laboratory animals; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Airway hyperresponsiveness; Author-Supplied Keyword: Allergen; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Dermatophagoides farinae; Author-Supplied Keyword: Dust mite; Author-Supplied Keyword: Pulmonary inflammation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.intimp.2008.07.015
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parveen, Salina
AU - Hettiarachchi, Kumidini A.
AU - Bowers, John C.
AU - Jones, Jessica L.
AU - Tamplin, Mark L.
AU - McKay, Rusty
AU - Beatty, William
AU - Brohawn, Kathy
AU - DaSilva, Ligia V.
AU - DePaola, Angelo
T1 - Seasonal distribution of total and pathogenic Vibrio parahaemolyticus in Chesapeake Bay oysters and waters
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2008/12/10/
VL - 128
IS - 2
M3 - Article
SP - 354
EP - 361
SN - 01681605
AB - Abstract: The objectives of this study were to investigate the seasonal distribution of total and pathogenic Vibrio parahaemolyticus in the Chesapeake Bay oysters and waters, and to determine the degree of association between V. parahaemolyticus densities and selected environmental parameters. Oyster and water samples were collected monthly from three sites in Chesapeake Bay, Maryland from November 2004 through October 2005. During collection of samples, water temperature, salinity, turbidity, dissolved oxygen, pH, chlorophyll a, and fecal coliform levels in oysters were also determined. V. parahaemolyticus levels were enumerated by a quantitative direct-plating method followed by DNA colony hybridization; presence/absence was further determined by overnight broth enrichment followed by either standard colony isolation or real-time PCR. The thermolabile hemolysin (tlh) gene and thermostable direct hemolysin (tdh) gene were targeted for detection of total and pathogenic V. parahaemolyticus, respectively, for both direct plating and enrichment. The thermostable related hemolysin (trh) gene, which is a presumptive pathogenicity marker, was targeted only for the enrichment approach. By direct plating, colonies producing tlh signals were detected in 79% of oyster samples at densities ranging from 1.5×101 to 6.0×102 CFU/g. Pathogenic V. parahaemolyticus (tdh+) was detected in 3% (level was 10 CFU/g) of oyster samples while no V. parahaemolyticus was detected in water samples. By the enrichment approach with standard colony isolation, 67% of oyster and 55% of water samples (n =33) were positive for total V. parahaemolyticus, and all samples were negative for pathogenic V. parahaemolyticus. In contrast, enrichment followed by real-time PCR detected tlh, tdh and trh in 100%, 20% and 40% of oyster and 100%, 13% and 40% of water enrichments collected from June to October 2005, respectively. V. parahaemolyticus densities in oysters varied seasonally and were found to be positively correlated with water temperature, turbidity, and dissolved oxygen. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Water pollution
KW - Colonization (Ecology)
KW - Oysters -- Contamination
KW - Seasonal distribution of fishes
KW - Vibrio parahaemolyticus -- Detection
KW - Polymerase chain reaction
KW - Chesapeake Bay (Md. & Va.)
KW - Maryland
KW - Virginia
KW - Chesapeake Bay
KW - Seasonal distribution
KW - V. parahaemolyticus
N1 - Accession Number: 35201610; Parveen, Salina 1; Email Address: sparveen@umes.edu; Hettiarachchi, Kumidini A. 1; Bowers, John C. 2; Jones, Jessica L. 3; Tamplin, Mark L. 4; McKay, Rusty 5; Beatty, William 5; Brohawn, Kathy 5; DaSilva, Ligia V. 1; DePaola, Angelo 5; Affiliations: 1: Food Science and Technology Ph. D. Program, Department of Agriculture, Food and Resource Sciences, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States; 2: Division of Public Health and Biostatistics, U. S. Food and Drug Administration, College Park, Maryland 20740, United States; 3: Gulf Coast Seafood Laboratory, U. S. Food and Drug Administration, Dauphin Island, Alabama 36528, United States; 4: Food Safety Centre, University of Tasmania, Hobart, Tasmania 7001, Australia; 5: Maryland Department of the Environment, Baltimore, Maryland 21230, United States; Issue Info: Dec2008, Vol. 128 Issue 2, p354; Thesaurus Term: Water pollution; Thesaurus Term: Colonization (Ecology); Thesaurus Term: Oysters -- Contamination; Subject Term: Seasonal distribution of fishes; Subject Term: Vibrio parahaemolyticus -- Detection; Subject Term: Polymerase chain reaction; Subject: Chesapeake Bay (Md. & Va.); Subject: Maryland; Subject: Virginia; Author-Supplied Keyword: Chesapeake Bay; Author-Supplied Keyword: Seasonal distribution; Author-Supplied Keyword: V. parahaemolyticus; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2008.09.019
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mazurek, J. M.
AU - Wood, J. M.
T1 - Asbestosis-Related Years of Potential Life Lost Before Age 65 Years -- United States, 1968-2005. (Cover story)
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2008/12/12/
VL - 57
IS - 49
M3 - Article
SP - 1321
EP - 1325
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - This article discusses the results of an analysis of trends in premature mortality attributed to asbestosis in the U.S. from 1968 to 2005. The analysis indicated that annual years of potential life lost before age 65 years (YPLL) attributed to asbestosis increased 64 percent. The results demonstrate that asbestosis-attributable YPLL continue to occur and that efforts to prevent, track and eliminate asbestosis need to be maintained.
KW - ASBESTOSIS
KW - MORTALITY
KW - LUNGS -- Dust diseases
KW - PREVENTIVE medicine
KW - UNITED States
N1 - Accession Number: 35857703; Mazurek, J. M. 1 Wood, J. M. 1; Affiliation: 1: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 12/12/2008, Vol. 57 Issue 49, p1321; Subject Term: ASBESTOSIS; Subject Term: MORTALITY; Subject Term: LUNGS -- Dust diseases; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105604672
T1 - Asbestosis-related years of potential life lost before age 65 years -- United States, 1968-2005.
AU - Mazurek JM
AU - Wood JM
Y1 - 2008/12/12/
N1 - Accession Number: 105604672. Language: English. Entry Date: 20090227. Revision Date: 20151015. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Public Health; USA. Special Interest: Public Health. NLM UID: 7802429.
KW - Life Expectancy
KW - Pneumoconiosis -- Mortality -- United States
KW - Descriptive Statistics
KW - Epidemiological Research
KW - Occupational Diseases
KW - Occupational Exposure
KW - United States
KW - Human
SP - 1321
EP - 1325
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
JA - MMWR MORB MORTAL WKLY REP
VL - 57
IS - 49
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
SN - 0149-2195
AD - Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC
U2 - PMID: 19078920.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - McMenamin, Jim
AU - Phin, Nick
AU - Smyth, Brian
AU - Couzens, Zoe
AU - Nguyen-Van-Tam, Jonathan S.
T1 - Minimum dataset for confirmed human cases of influenza H5N1.
JO - Lancet
JF - Lancet
Y1 - 2008/12/13/
VL - 372
IS - 9655
M3 - Letter
SP - 2022
EP - 2022
SN - 00995355
AB - A letter to the editor is presented in response to the article "Minimum Dataset Needed for confirmed Human HSN1Cases," by S. Bird and J. Farrar.
KW - LETTERS to the editor
KW - AVIAN influenza
N1 - Accession Number: 35754566; McMenamin, Jim 1; Email Address: Jim.McMenamin@hps.scot.nhs.uk Phin, Nick 2 Smyth, Brian 3 Couzens, Zoe 4 Nguyen-Van-Tam, Jonathan S. 5; Affiliation: 1: Health Protection Scotland, Glasgow G3 7LN, UK 2: Health Protection Agency, Centre for Infections, London, UK 3: Communicable Disease Surveillance Centre (Northern Ireland), Belfast City Hospital, Belfast, UK 4: Natioanl Public Health Service for Wales, Communicable Disease Surveillance Centre, Cardiff, UK 5: University of Nottingham, City Hospital, Nottingham, UK; Source Info: 12/13/2008, Vol. 372 Issue 9655, p2022; Subject Term: LETTERS to the editor; Subject Term: AVIAN influenza; Number of Pages: 4/5p; Illustrations: 1 Black and White Photograph; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105610313
T1 - Putting prevention into practice: an evidence-based approach. Screening for chlamydial infection.
AU - Lin KW
AU - Ramsey L
Y1 - 2008/12/15/
N1 - Accession Number: 105610313. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article; case study; exam questions. Note: For CE see pages 1341-3, 1404, 1p. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Chlamydia Infections -- Diagnosis
KW - Health Screening -- Methods
KW - Adult
KW - Education, Continuing (Credit)
KW - Female
KW - Pregnancy
KW - Prenatal Care -- Methods
SP - 1349
EP - 1350
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 78
IS - 12
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19119552.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Gupta, Abhay
AU - Hunt, Robert L.
AU - Khan, Mansoor A.
T1 - Influence of tablet characteristics on weight variability and weight loss in split tablets.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2008/12/15/
VL - 65
IS - 24
M3 - Letter
SP - 2326
EP - 2328
PB - American Society of Health System Pharmacists
SN - 10792082
AB - A letter to the editor is presented which presents a discussion on split tablets.
KW - LETTERS to the editor
KW - TABLETS (Medicine)
N1 - Accession Number: 35584163; Gupta, Abhay 1 Hunt, Robert L. 2 Khan, Mansoor A. 3; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Pharmacologist, Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. 2: Chemist, Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. 3: Director, Division of Product Quality Research, Office of Pharmaceutical Science, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993.; Source Info: 12/15/2008, Vol. 65 Issue 24, p2326; Subject Term: LETTERS to the editor; Subject Term: TABLETS (Medicine); Number of Pages: 2p; Document Type: Letter
L3 - 10.2146/ajhp080371
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chumakov, Konstantin
AU - Ehrenfeld, Ellie
T1 - New Generation of Inactivated Poliovirus Vaccines for Universal Immunization after Eradication of Poliomyelitis.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2008/12/15/
VL - 47
IS - 12
M3 - Article
SP - 1587
EP - 1592
SN - 10584838
AB - Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. Although 2 excellent vaccines have proven to be highly effective in the past, neither the live-attenuated vaccine nor the currently used inactivated vaccine are optimal for use in the posteradication era. Therefore, concerted efforts are urgently needed to develop a new generation of vaccine that is risk-free and affordable and can be produced on a global scale. Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Communicable diseases -- Transmission
KW - Immunization
KW - Biologicals
KW - Immunity
KW - Polio -- Prevention
KW - Vaccines -- Therapeutic use
KW - Polio
N1 - Accession Number: 35442754; Chumakov, Konstantin 1; Email Address: konstantin.chumakov@fda.hhs.gov; Ehrenfeld, Ellie 2; Affiliations: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville; 2: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Issue Info: 12/15/2008, Vol. 47 Issue 12, p1587; Thesaurus Term: VACCINATION; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Immunization; Thesaurus Term: Biologicals; Thesaurus Term: Immunity; Subject Term: Polio -- Prevention; Subject Term: Vaccines -- Therapeutic use; Subject Term: Polio; Number of Pages: 6p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1086/593310
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Robertson, Sarah M.
AU - Maldarelli, Frank
AU - Natarajan, Ven
AU - Formentini, Elizabeth
AU - Alfaro, Raul M.
AU - Penzak, Scott R.
T1 - Efavirenz Induces CYP2B6-Mediated Hydroxylation of Bupropion in Healthy Subjects.
JO - JAIDS: Journal of Acquired Immune Deficiency Syndromes
JF - JAIDS: Journal of Acquired Immune Deficiency Syndromes
Y1 - 2008/12/15/
VL - 49
IS - 5
M3 - Article
SP - 513
EP - 519
SN - 15254135
AB - The article presents the study on the characterization of the effect of efavirenz on bupropion hydroxylation as a marker of cytochrome P450 (CYP) 2B6 activity in healthy samples. It discusses the methods used in studying the effects of a single oral dose of bupropion SR 150 mg before and after two weeks of efavirenz administration on 13 patients. It also discusses the conclusion of the study which confirms that efavirenz induces CYP2B6 enzyme activity in vivo.
KW - HYDROXYLATION
KW - CYTOCHROME P-450
KW - ENZYME induction
KW - RESEARCH -- Methodology
KW - ENZYMES -- Analysis
KW - METABOLISM
KW - bupropion
KW - CYP2B6
KW - drug interaction
KW - efavirenz
KW - induction
KW - metabolism
N1 - Accession Number: 37011058; Robertson, Sarah M. 1; Email Address: sarah.robertson@fda.hhs.gov Maldarelli, Frank 2 Natarajan, Ven 3 Formentini, Elizabeth 4 Alfaro, Raul M. 5 Penzak, Scott R. 5; Affiliation: 1: Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, MD 2: HIV Drug Resistance Program, SAIC-Frederick, National Cancer Institute, Frederick, MD 3: Laboratory of Molecular Cell Biology, SAIC-Frederick, National Cancer Institute, Frederick, MD 4: Department of Critical Care Medicine, National Institutes of Health, Bethesda, MD 5: Clinical Research Center, Department of Pharmacy, National Institutes of Health, Bethesda, MD; Source Info: 12/15/2008, Vol. 49 Issue 5, p513; Subject Term: HYDROXYLATION; Subject Term: CYTOCHROME P-450; Subject Term: ENZYME induction; Subject Term: RESEARCH -- Methodology; Subject Term: ENZYMES -- Analysis; Subject Term: METABOLISM; Author-Supplied Keyword: bupropion; Author-Supplied Keyword: CYP2B6; Author-Supplied Keyword: drug interaction; Author-Supplied Keyword: efavirenz; Author-Supplied Keyword: induction; Author-Supplied Keyword: metabolism; Number of Pages: 7p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105615606
T1 - Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.
AU - Reed JL
AU - Brewah YA
AU - Delaney T
AU - Welliver T
AU - Burwell T
AU - Benjamin E
AU - Kuta E
AU - Kozhich A
AU - McKinney L
AU - Suzich J
AU - Kiener PA
AU - Avendano L
AU - Velozo L
AU - Humbles A
AU - Welliver RC
AU - Coyle AJ
Y1 - 2008/12/15/
N1 - Accession Number: 105615606. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Airway Obstruction
KW - Airway Obstruction -- Pathology
KW - Bronchiolitis -- Complications
KW - Macrophages -- Physiology
KW - Respiratory Syncytial Virus Infections -- Complications
KW - Animals
KW - Diphosphonates -- Pharmacodynamics
KW - Immunity
KW - Infant, Newborn
KW - Mice
KW - Respiratory Syncytial Viruses
SP - 1783
EP - 1793
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 198
IS - 12
PB - Oxford University Press / USA
AB - Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described. We studied histopathologic changes in a panel of lung tissue specimens obtained from infants with fatal cases of primary RSV infection. In these tissues, airway occlusion with accumulations of infected, apoptotic cellular debris and serum protein was consistently observed. Similar observations were found after RSV infection in New Zealand black (NZB) mice, which have constitutive deficiencies in macrophage function, but not in BALB/c mice. A deficiency in the number of alveolar macrophages in NZB mice appears to be central to enhanced disease, because depletion of alveolar macrophages in BALB/c mice before RSV exposure resulted in airway occlusion. In mice with insufficient numbers of macrophages, RSV infection yielded an increased viral load and enhanced expression of type I interferon-associated genes at the height of disease. Together, our data suggest that innate, rather than adaptive, immune responses are critical determinants of the severity of RSV bronchiolitis. © 2008 by the Infectious Diseases Society of America. All rights reserved.
SN - 0022-1899
AD - Food and Drug Administration, Center for Biologics Evaluation and Research, 8800 Rockville Pike HFM-345, Bethesda, MD 20892; jennifer.reed@fda.hhs.gov
U2 - PMID: 18980502.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shankar, Gopi
AU - Devanarayan, Viswanath
AU - Amaravadi, Lakshmi
AU - Barrett, Yu Chen
AU - Bowsher, Ronald
AU - Finco-Kent, Deborah
AU - Fiscella, Michele
AU - Gorovits, Boris
AU - Kirschner, Susan
AU - Moxness, Michael
AU - Parish, Thomas
AU - Quarmby, Valerie
AU - Smith, Holly
AU - Smith, Wendell
AU - Zuckerman, Linda A.
AU - Koren, Eugen
T1 - Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/12/15/
VL - 48
IS - 5
M3 - Article
SP - 1267
EP - 1281
SN - 07317085
AB - Abstract: Most biological drug products elicit some level of anti-drug antibody (ADA) response. This antibody response can, in some cases, lead to potentially serious side effects and/or loss of efficacy. In humans, ADA often causes no detectable clinical effects, but in the instances of some therapeutic proteins these antibodies have been shown to cause a variety of clinical consequences ranging from relatively mild to serious adverse events. In nonclinical (preclinical) studies, ADA can affect drug exposure, complicating the interpretation of the toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) data. Therefore, the immunogenicity of therapeutic proteins is a concern for clinicians, manufacturers and regulatory agencies. In order to assess the immunogenic potential of biological drug molecules, and be able to correlate laboratory results with clinical events, it is important to develop reliable laboratory test methods that provide valid assessments of antibody responses in both nonclinical and clinical studies. For this, method validation is considered important, and is a necessary bioanalytical component of drug marketing authorization applications. Existing regulatory guidance documents dealing with the validation of methods address immunoassays in a limited manner, and in particular lack information on the validation of immunogenicity methods. Hence this article provides scientific recommendations for the validation of ADA immunoassays. Unique validation performance characteristics are addressed in addition to those provided in existing regulatory documents pertaining to bioanalyses. The authors recommend experimental and statistical approaches for the validation of immunoassay performance characteristics; these recommendations should be considered as examples of best practice and are intended to foster a more unified approach to antibody testing across the biopharmaceutical industry. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOASSAY
KW - TEST methods
KW - DRUGS -- Side effects
KW - BIOMEDICAL materials
KW - DRUGS -- Effectiveness
KW - IMMUNOGLOBULINS
KW - IMMUNOGENETICS
KW - Anti-drug antibody
KW - Immunoassay
KW - Immunogenicity
KW - Method validation
N1 - Accession Number: 36191859; Shankar, Gopi 1 Devanarayan, Viswanath 2 Amaravadi, Lakshmi 3 Barrett, Yu Chen 4 Bowsher, Ronald 5 Finco-Kent, Deborah 6 Fiscella, Michele 7 Gorovits, Boris 8 Kirschner, Susan 9 Moxness, Michael 10 Parish, Thomas 11 Quarmby, Valerie 12 Smith, Holly 13 Smith, Wendell 14 Zuckerman, Linda A. 15 Koren, Eugen 16; Email Address: eugen.koren@av.abbott.com; Affiliation: 1: Clinical Pharmacology Sciences, Centocor Research & Development Inc., Radnor, PA 19087, USA 2: Global Exploratory Statistics, Abbott Laboratories, Parsippany, NJ 07054, USA 3: Preclinical & Clinical Development Sciences, Biogen Idec, Cambridge, MA 02142, USA 4: Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ 08543, USA 5: Millipore, BioPharma Services Division, 15 Research Park Dr., St. Charles, MO 63304, USA and B2S Consulting, Beech Grove, IN 46107, USA 6: Drug Safety Research and Development, Pfizer, Groton, CT 06340, USA 7: Human Genome Sciences, 14200 Shady Grove Road, Rockville, MD 20850, USA 8: Drug Safety and Metabolism, Wyeth, Pearl River, NY 10965, USA 9: Office of Biotechnology Products, CDER, Food and Drug Administration, Bethesda, MD 20892, USA 10: Clinical Immunology, Medical Sciences, Amgen Inc., Thousand Oaks, CA 91320, USA 11: Analytical Science Department, Procter & Gamble Pharmaceuticals, Norwich, NY 13815, USA 12: BioAnalytical Research & Development, Genentech, South San Francisco, CA 94080, USA 13: Investigative Toxicology, Eli Lilly and Company, Greenfield, IN 46140, USA 14: B2S Consulting, 1305 Chapman Drive, Greenfield, IN 46140, USA 15: PreClinical Development Department, ZymoGenetics Inc., Seattle, WA 98102, USA 16: Bioanalytical R&D, Abbott Vascular Inc., Santa Clara, CA 95054, USA; Source Info: Dec2008, Vol. 48 Issue 5, p1267; Subject Term: IMMUNOASSAY; Subject Term: TEST methods; Subject Term: DRUGS -- Side effects; Subject Term: BIOMEDICAL materials; Subject Term: DRUGS -- Effectiveness; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOGENETICS; Author-Supplied Keyword: Anti-drug antibody; Author-Supplied Keyword: Immunoassay; Author-Supplied Keyword: Immunogenicity; Author-Supplied Keyword: Method validation; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.jpba.2008.09.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kauffman, John F.
AU - Batykefer, Linda M.
AU - Tuschel, David D.
T1 - Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/12/15/
VL - 48
IS - 5
M3 - Article
SP - 1310
EP - 1315
SN - 07317085
AB - Abstract: Acetaminophen is known to crystallize in three polymorphic forms. Thermally induced transformations between the crystalline forms and the super-cooled liquid have been observed by differential scanning calorimetry (DSC), but the assignment of calorimetric transitions to specific polymorphic transformations remains challenging, because the transition temperatures for several transformations are close to one another, and the characteristics of the observed transitions depend on experimental variables that are often poorly controlled. This paper demonstrates the simultaneous application of DSC and Raman microscopy for the observation of thermally driven transitions between polymorphs of pharmaceutical materials. Raman detected differential scanning calorimetry (RD-DSC) has been used to monitor the DSC thermograms of super-cooled liquid acetaminophen and confirms the assignment of two exothermic transitions to specific polymorphic transformations. Principal component analysis of the Raman spectra have been used to determine the number of independent components that participate in the phase transformations, and multivariate regression has been used to determine transition temperatures from the spectral data. The influence of the laser excitation source on measured DSC thermograms has also been investigated, and it has been demonstrated that a baseline shift occurs in RD-DSC when a polymorphic transformation occurs between crystalline and amorphous forms. RD-DSC has been used to examine the influence of sample aging and sample pan configuration on the observed polymorphic transformations, and both of these variables were found to influence the thermal behavior of the sample. The results demonstrate the advantage of simultaneous Raman spectroscopy and differential scanning calorimetry for the unambiguous assignment of thermally driven polymorphic transformations. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETAMINOPHEN
KW - POLYMORPHISM (Crystallography)
KW - RAMAN spectroscopy
KW - CALORIMETRY
KW - SUPERCOOLED liquids
KW - RAMAN effect
KW - TEMPERATURE measuring instruments
KW - Acetaminophen
KW - Differential scanning calorimetry
KW - Polymorphism
KW - Raman spectroscopy
N1 - Accession Number: 36191863; Kauffman, John F. 1; Email Address: John.Kauffman@fda.hhs.gov Batykefer, Linda M. 2 Tuschel, David D. 2; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 1114 Market Street, St. Louis, MO 63101, United States 2: ChemImage Corporation, 7301 Penn Avenue, Pittsburgh, PA, United States; Source Info: Dec2008, Vol. 48 Issue 5, p1310; Subject Term: ACETAMINOPHEN; Subject Term: POLYMORPHISM (Crystallography); Subject Term: RAMAN spectroscopy; Subject Term: CALORIMETRY; Subject Term: SUPERCOOLED liquids; Subject Term: RAMAN effect; Subject Term: TEMPERATURE measuring instruments; Author-Supplied Keyword: Acetaminophen; Author-Supplied Keyword: Differential scanning calorimetry; Author-Supplied Keyword: Polymorphism; Author-Supplied Keyword: Raman spectroscopy; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2008.09.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36191863&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Hongmin
AU - Chen, Shiwei
AU - Qin, Feng
AU - Huang, Xi
AU - Ren, Ping
AU - Gu, Xinqi
T1 - Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2008/12/15/
VL - 48
IS - 5
M3 - Article
SP - 1462
EP - 1466
SN - 07317085
AB - Abstract: An HPLC-photodiode array (PDA) detection method was established for the simultaneous determination of 12 components in Xiao-Yao-San-Jia-Wei (XYSJW): geniposide, puerarin, paeoniflorin, ferulic acid, liquiritin, hesperidin, naringin, paeonol, daidzein, glycyrrhizic acid, honokiol, and magnolol. These were separated in less than 70min using a Waters Symmetry Shield RP 18 column with gradient elution using (A) acetonitrile, (B) water, and (C) acetic acid at a flow rate of 1ml/min, and with a PDA detector. All calibration curves showed good linear regression (r 2 >0.9992) within the test ranges. The method was validated for specificity, accuracy, precision, and limits of detection. The proposed method enables in a single run the simultaneous identification and determination for quality control of 12 multi-structural components of XYSJW forming the basis of its therapeutic effect. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHINESE medicine
KW - PHARMACEUTICAL chemistry
KW - PHOTODIODES
KW - PRESCRIPTION of drugs
KW - HIGH performance liquid chromatography
KW - REGRESSION analysis
KW - Chemical constituents
KW - HPLC-PDA
KW - Traditional Chinese Medicinal Prescription
KW - Xiao-Yao-San-Jia-Wei
N1 - Accession Number: 36191886; Zhang, Hongmin 1,2 Chen, Shiwei 3 Qin, Feng 4 Huang, Xi 2,4; Email Address: tcmhuangx59@163.com Ren, Ping 4; Email Address: renping3@163.com Gu, Xinqi 2; Affiliation: 1: Henan Eye Institute and Department of Ophthalmology, Henan Provincial People’s Hospital, Zhengzhou 450003, PR China 2: Laboratory of Ethnopharmacology and Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China 3: Henan Food and Drug Administration, Zhengzhou 450012, PR China 4: Laboratory of Ethnopharmacology and Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, PR China; Source Info: Dec2008, Vol. 48 Issue 5, p1462; Subject Term: CHINESE medicine; Subject Term: PHARMACEUTICAL chemistry; Subject Term: PHOTODIODES; Subject Term: PRESCRIPTION of drugs; Subject Term: HIGH performance liquid chromatography; Subject Term: REGRESSION analysis; Author-Supplied Keyword: Chemical constituents; Author-Supplied Keyword: HPLC-PDA; Author-Supplied Keyword: Traditional Chinese Medicinal Prescription; Author-Supplied Keyword: Xiao-Yao-San-Jia-Wei; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jpba.2008.09.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36191886&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schünemann, Holger J.
AU - Oxman, Andrew D.
AU - Brozek, Jan
AU - Glasziou, Paul
AU - Bossuyt, Patrick
AU - Chang, Stephanie
AU - Muti, Paola
AU - Jaeschke, Roman
AU - Guyatt, Gordon H.
T1 - GRADE: assessing the quality of evidence for diagnostic recommendations (Editorial).
JO - ACP Journal Club
JF - ACP Journal Club
Y1 - 2008/12/16/
VL - 149
IS - 6
M3 - Article
SP - 1
EP - 1
SN - 10568751
AB - The article discusses a rigorous approach adopted by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group. As stated, GRADE's framework for developing recommendations for diagnostic management studies is based on what is needed to weigh the benefits and harms of ordering and using a diagnostic test in caring for patients. The GRADE approach requires making judgments about the relation between accuracy and patient-important outcomes transparent.
KW - DIAGNOSIS
KW - OUTCOME assessment (Medical care)
KW - PATIENTS
KW - MEDICAL care
KW - MEDICAL screening
KW - Diagnosis
KW - Evidence-Based Medicine
N1 - Accession Number: 36024703; Schünemann, Holger J. 1 Oxman, Andrew D. 2 Brozek, Jan 3 Glasziou, Paul 4 Bossuyt, Patrick 5 Chang, Stephanie 6 Muti, Paola 3 Jaeschke, Roman 1 Guyatt, Gordon H. 1; Affiliation: 1: McMaster University, Hamilton, Ontario, Canada. 2: Norwegian Knowledge Centre for the Health Services, Oslo, Norway. 3: Italian National Cancer Institute Regina Elena, Rome, Italy. 4: University of Oxford, University of Oxford. 5: University of Amsterdam, Amsterdam, Netherlands. 6: Agency for Healthcare Research and Quality, Rockville, Maryland, USA.; Source Info: 12/16/2008, Vol. 149 Issue 6, p1; Subject Term: DIAGNOSIS; Subject Term: OUTCOME assessment (Medical care); Subject Term: PATIENTS; Subject Term: MEDICAL care; Subject Term: MEDICAL screening; Author-Supplied Keyword: Diagnosis; Author-Supplied Keyword: Evidence-Based Medicine; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 1p; Illustrations: 1 Black and White Photograph; Document Type: Article; Full Text Word Count: 1511
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, William F.
AU - Rosenberg, Philip S.
AU - Menashe, Idan
AU - Mitani, Aya
AU - Pfeiffer, Ruth M.
T1 - Age-Related Crossover in Breast Cancer Incidence Rates Between Black and White Ethnic Groups.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2008/12/17/
VL - 100
IS - 24
M3 - Article
SP - 1804
EP - 1814
SN - 00278874
AB - Background. Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact. Method.s To quantify this incidence rate crossover, we examined data for 440653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results.. database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided. Results. We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference = 2.4, 95% confidence interval [Cl] = 2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference = 41.8, 95% Cl = 41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P< .001 for difference by race). Conclusion. Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer -- Patients
KW - BLACK women
KW - DISEASES
KW - WHITE women
KW - TUMORS
KW - COHORT analysis
KW - REGRESSION analysis
KW - RISK factors
N1 - Accession Number: 36042377; Anderson, William F. 1; Email Address: wanderso@mail.nih.gov Rosenberg, Philip S. 1 Menashe, Idan 1 Mitani, Aya 2 Pfeiffer, Ruth M. 1; Affiliation: 1: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, USA 2: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA; Source Info: 12/17/2008, Vol. 100 Issue 24, p1804; Subject Term: BREAST cancer -- Patients; Subject Term: BLACK women; Subject Term: DISEASES; Subject Term: WHITE women; Subject Term: TUMORS; Subject Term: COHORT analysis; Subject Term: REGRESSION analysis; Subject Term: RISK factors; Number of Pages: 11p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1093/jnci/djn411
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36042377&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105608785
T1 - Age-related crossover in breast cancer incidence rates between black and white ethnic groups.
AU - Anderson WF
AU - Rosenberg PS
AU - Menashe I
AU - Mitani A
AU - Pfeiffer RM
AU - Anderson, William F
AU - Rosenberg, Philip S
AU - Menashe, Idan
AU - Mitani, Aya
AU - Pfeiffer, Ruth M
Y1 - 2008/12/17/
N1 - Accession Number: 105608785. Language: English. Entry Date: 20090130. Revision Date: 20161116. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Oncologic Care. Grant Information: //Intramural NIH HHS/United States. NLM UID: 7503089.
KW - Blacks -- Statistics and Numerical Data
KW - Breast Neoplasms -- Ethnology
KW - Whites -- Statistics and Numerical Data
KW - Adult
KW - Age Factors
KW - Aged
KW - Confounding Variable
KW - Demography
KW - Female
KW - Incidence
KW - Mathematics
KW - Middle Age
KW - Registries, Disease
KW - Reproducibility of Results
KW - Retrospective Design
KW - United States
KW - Human
SP - 1804
EP - 1814
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
JA - J NATL CANCER INST
VL - 100
IS - 24
PB - Oxford University Press / USA
AB - Background: Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact.Methods: To quantify this incidence rate crossover, we examined data for 440 653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided.Results: We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100 000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference = 2.4, 95% confidence interval [CI] = 2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference = 41.8, 95% CI = 41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P < .001 for difference by race).Conclusion: Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects.
SN - 0027-8874
AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892-7244, USA
AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892-7244, USA. wanderso@mail.nih.gov
U2 - PMID: 19066264.
DO - 10.1093/jnci/djn411
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105608785&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Guo, Changning
AU - Stine, Keith J.
AU - Kauffman, John F.
AU - Doub, William H.
T1 - Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
Y1 - 2008/12/18/
VL - 35
IS - 5
M3 - Article
SP - 417
EP - 426
SN - 09280987
AB - Abstract: The purpose of the research was to investigate the influences of actuation parameters and formulation physical properties on nasal spray delivery performance using design of experiment (DOE) methodology. A 3-level, 4-factor Box-Behnken design with a total of 27 experimental runs was used in this study. Nine simulated aqueous formulations with different viscosities and surface tensions were prepared using carboxymethylcellulose sodium (CMC, gelling agent) and Tween80 (surfactant) each at three concentration levels. Four factors, actuation stroke length, actuation velocity, concentration of gelling agent, and concentration of surfactant were investigated for their influences on measured responses of shot weight, spray pattern, plume geometry and droplet size distribution (DSD). The models based on data from the DOE were then optimized by eliminating insignificant terms. Pfeiffer nasal spray pump units filled with the simulated formulations were used in the study. Nasal pump actuation stroke length exerts a strong, independent influence on shot weight, and also slightly affects spray pattern and plume geometry. Actuation velocity and concentration of gelling agent have significant effects on spray pattern, plume geometry and DSD, in a complicated manner through interaction terms. Concentration of surfactant has little, if any, influence on nasal spray characteristics. Results were fitted to quadratic models describing the inherent relationships between the four factors evaluated and nasal spray performance. The DOE study helped us to identify the source of variability in nasal spray product performance, and obtained better understanding in how to control the variability. Moreover, the quadratic models developed from the DOE study quantitatively describe the inherent relationships between the factors and nasal spray performance characteristics. With the assistance of the response surfaces developed from the DOE model, the time and labor in designing a nasal spray product to achieve desired product performance characteristics can be reduced. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARANASAL sinuses
KW - DRUG delivery devices
KW - SURFACE tension
KW - VISCOSITY
KW - Automated actuation
KW - Box-Behnken experimental design
KW - Droplet size distribution
KW - In vitro testing
KW - Nasal drug delivery
KW - Plume geometry
KW - Shot weight
KW - Spray pattern
KW - Surface tension
KW - Viscosity
N1 - Accession Number: 35326793; Guo, Changning 1; Email Address: changning.guo@fda.hhs.gov Stine, Keith J. 2 Kauffman, John F. 1 Doub, William H. 1; Affiliation: 1: Division of Pharmaceutical Analysis, U.S. Food and Drug Administration, 1114 Market Street, Room 1002, St. Louis, MO 63101, United States 2: Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri at St. Louis, 315 Benton Hall, One University Boulevard, St. Louis, MO 63121, United States; Source Info: Dec2008, Vol. 35 Issue 5, p417; Subject Term: PARANASAL sinuses; Subject Term: DRUG delivery devices; Subject Term: SURFACE tension; Subject Term: VISCOSITY; Author-Supplied Keyword: Automated actuation; Author-Supplied Keyword: Box-Behnken experimental design; Author-Supplied Keyword: Droplet size distribution; Author-Supplied Keyword: In vitro testing; Author-Supplied Keyword: Nasal drug delivery; Author-Supplied Keyword: Plume geometry; Author-Supplied Keyword: Shot weight; Author-Supplied Keyword: Spray pattern; Author-Supplied Keyword: Surface tension; Author-Supplied Keyword: Viscosity; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.ejps.2008.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35326793&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Min-Chul
AU - Choi, Hee-Sook
AU - Lee, Sojung
AU - Kim, Bo Yeon
AU - Jung, Mira
AU - Park, Sue Nie
AU - Yoon, Do-Young
T1 - Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2008/12/19/
VL - 377
IS - 3
M3 - Article
SP - 832
EP - 837
SN - 0006291X
AB - Abstract: Epiregulin belongs to the epidermal growth factor family, binds to the epidermal growth factor receptor, and its expression is upregulated in various cancer cells, but the regulatory mechanism is unclear. We investigated the regulatory mechanism of epiregulin expression in Ki-ras-transformed cancer cells. In 267B1/Ki-ras cells, the RAF/MEK/ERK pathway was constitutively activated, epiregulin was up-regulated, and the expression and phosphorylation of Ets-1 were augmented. The inhibition of ERK by PD98059 decreased epiregulin and Ets-1 expression and suppressed the growth of 267B1/Ki-ras cells. A chromatin immunoprecipitation assay demonstrated that Ets-1 was bound to human epiregulin promoter, and this binding was abolished by PD98059. Silencing of Ets-1 by RNA interference decreased cellular epiregulin transcript expression. We suggest that the Ki-ras mutation in 267B1 prostate cells constitutively activates the RAF/MEK/ERK pathway and induces the activation of the Ets-1 transcription factor, ultimately leading to the increased expression of epiregulin. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDERMAL growth factor
KW - GENE expression
KW - CANCER cells
KW - PHOSPHORYLATION
KW - PROMOTERS (Genetics)
KW - TRANSCRIPTION factors
KW - Epiregulin
KW - Ets-1
KW - Ki-ras
KW - Oncogene
KW - Prosate cancer
KW - RAF/MEK/ERK pathway
N1 - Accession Number: 35392911; Cho, Min-Chul 1 Choi, Hee-Sook 1 Lee, Sojung 1 Kim, Bo Yeon 2 Jung, Mira 3 Park, Sue Nie 4 Yoon, Do-Young 1; Email Address: ydy4218@konkuk.ac.kr; Affiliation: 1: Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayng-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea 2: Laboratory of Cellular Signaling Modulators, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, Daejeon 305-333, Republic of Korea 3: Department of Radiation Medicine, Georgetown University School of Medicine, Washington, DC 20057-1482, USA 4: Genetic Toxicology Division, NITR, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Dec2008, Vol. 377 Issue 3, p832; Subject Term: EPIDERMAL growth factor; Subject Term: GENE expression; Subject Term: CANCER cells; Subject Term: PHOSPHORYLATION; Subject Term: PROMOTERS (Genetics); Subject Term: TRANSCRIPTION factors; Author-Supplied Keyword: Epiregulin; Author-Supplied Keyword: Ets-1; Author-Supplied Keyword: Ki-ras; Author-Supplied Keyword: Oncogene; Author-Supplied Keyword: Prosate cancer; Author-Supplied Keyword: RAF/MEK/ERK pathway; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bbrc.2008.10.053
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35392911&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Delmonte, Pierluigi
AU - Hu, Qing
AU - Kia, Ali-Reza Fardin
AU - Rader, Jeanne I.
T1 - Preparation, chromatographic separation and relative retention times of cis/trans heptadecaenoic (17:1) fatty acids
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2008/12/19/
VL - 1214
IS - 1/2
M3 - Article
SP - 30
EP - 36
SN - 00219673
AB - Abstract: In recent years, several countries have implemented new regulations regarding limitations or labeling of the trans fatty acid (tFA) content in foods. In order to comply with the new requirements, gas chromatographic methods for fatty acid (FA) analysis have been refined toward the quantitation of a larger number of FAs . Increased attention is also being paid to those present in lower quantities. This article describes a simple procedure for obtaining, pure or in mixtures, geometric and positional isomers of a commercially available monounsaturated FA . cis 10–17:1 Fatty acid methyl ester (FAME) was isomerized into its positional/geometrical isomers by repeated hydrobromination/dehydrobromination of its double bond. Reaction products were fractionated into cis and trans geometric isomers by silver ion HPLC. Pure cis-17:1 FAME positional isomers were obtained by reversed-phase HPLC fractionation and identified by gas chromatography – covalent adduct chemical ionization MS/MS using acetonitrile as the reacting gas. The isomerization with p-toluenesulfinic acid of the purified FAME yielded the corresponding trans isomers; these products were analyzed by GC with flame ionization detection using a Supelco 2560 capillary column in order to determine their elution order and retention times (t R). A novel procedure was developed to determine t r for 17:1 FAME positional/geometrical isomers relative to that of the commercially available cis 10–17:1 FAME. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONOUNSATURATED fatty acids
KW - SEPARATION (Technology)
KW - GAS chromatography
KW - ESTERS
KW - ISOMERIZATION
KW - CHEMICAL ionization mass spectrometry
KW - CHEMICAL bonds
KW - Fatty acids
KW - Heptadecenoic acid
KW - Lipids
KW - Trans fat
N1 - Accession Number: 35505420; Delmonte, Pierluigi 1; Email Address: Pierluigi.delmonte@fda.hhs.gov Hu, Qing 2 Kia, Ali-Reza Fardin 1 Rader, Jeanne I. 1; Affiliation: 1: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Pkwy, HFS-717, College Park, MD 20740, USA 2: Shanghai Institute for Food and Drug Control, 1500 Zhang-Heng Road, 201203 Shanghai, China; Source Info: Dec2008, Vol. 1214 Issue 1/2, p30; Subject Term: MONOUNSATURATED fatty acids; Subject Term: SEPARATION (Technology); Subject Term: GAS chromatography; Subject Term: ESTERS; Subject Term: ISOMERIZATION; Subject Term: CHEMICAL ionization mass spectrometry; Subject Term: CHEMICAL bonds; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Heptadecenoic acid; Author-Supplied Keyword: Lipids; Author-Supplied Keyword: Trans fat; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.chroma.2008.10.086
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35505420&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tami, Cecilia
AU - Puig, Montserrat
AU - Reepmeyer, John C.
AU - Ye, Hongping
AU - D'Avignon, D. Andre
AU - Buhse, Lucinda
AU - Verthelyi, Daniela
T1 - Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants
JO - Biomaterials
JF - Biomaterials
Y1 - 2008/12/20/
VL - 29
IS - 36
M3 - Article
SP - 4808
EP - 4814
SN - 01429612
AB - Abstract: Heparin and low molecular heparins are extensively used in the treatment of a wide range of diseases in addition to their classic anticoagulant activity and can be found coating medical devices such as catheters, stents and filters. Early in 2008, a sharp increase in heparin-associated severe adverse events, including over 80 deaths, was linked to the presence of a contaminant identified as hypersulfated chondroitin sulfate (OS-CS). OS-CS is one of several oversulfated glycosaminoglycans (GAGs) of different origins that can potentially cause similar clinical problems underscoring the need to develop robust screening methods for contaminants in existing and future lots of heparin. This study demonstrates that oversulfated GAGs block the activity of Taq polymerase used for real time PCR. Based on this finding we developed a simple, rapid, sensitive and high throughput screening method to detect and quantify oversulfated chondroitin sulfate (OS-CS) and other potential oversulfated contaminants in commercial lots of heparin. This method requires less than 100miliUnits (mU) of heparin as starting material, therefore avoiding the need to lyophilize and concentrate samples, and has a limit of detection of <1ng for all oversulfated GAGs tested. [Copyright &y& Elsevier]
AB - Copyright of Biomaterials is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA polymerases
KW - HEPARIN
KW - ANTICOAGULANTS (Medicine)
KW - CHONDROITIN sulfates
KW - MEDICAL equipment
KW - CATHETERS
KW - SURGICAL stents
KW - Glycosaminoglycan
KW - Heparin
KW - Oversulfated chondroitin sulfate
KW - PCR
KW - Safety
KW - Taq polymerase
N1 - Accession Number: 34772581; Tami, Cecilia 1 Puig, Montserrat 1 Reepmeyer, John C. 2 Ye, Hongping 2 D'Avignon, D. Andre 3 Buhse, Lucinda 2 Verthelyi, Daniela 1; Email Address: daniela.verthelyi@fda.hhs.gov; Affiliation: 1: Laboratory of Immunology, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drugs Evaluation and Research, Food and Drug Administration, Rockville Pike, Bethesda, MD 20892, United States 2: Division of Pharmaceutical Analysis, Center for Drugs Evaluation and Research, Food and Drug Administration, United States 3: Department of Chemistry, Washington University, St. Louis, MO, United States; Source Info: Dec2008, Vol. 29 Issue 36, p4808; Subject Term: DNA polymerases; Subject Term: HEPARIN; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: CHONDROITIN sulfates; Subject Term: MEDICAL equipment; Subject Term: CATHETERS; Subject Term: SURGICAL stents; Author-Supplied Keyword: Glycosaminoglycan; Author-Supplied Keyword: Heparin; Author-Supplied Keyword: Oversulfated chondroitin sulfate; Author-Supplied Keyword: PCR; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Taq polymerase; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biomaterials.2008.08.024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34772581&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
AU - Wu, John Z.
T1 - Analysis of handle dynamics-induced errors in hand biodynamic measurements
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2008/12/23/
VL - 318
IS - 4/5
M3 - Article
SP - 1313
EP - 1333
SN - 0022460X
AB - Abstract: Reliable experimental data of the driving-point biodynamic response (DPBR) of the hand–arm system are required to develop better biodynamic models for several important applications. The objectives of this study are to enhance the understanding of mechanisms of errors induced via the dynamics of instrumented handles and to identify a relatively more reliable method for DPBR measurement. A model of the handle–hand–arm system was developed and applied to examine various measurement methods. Both analytical and finite element methods were used to perform the examinations. This study found that the handle dynamic response could cause an uneven vibration distribution on its structures, especially at high frequencies (⩾500Hz), and hand coupling on the handle could influence the distribution characteristics. Whereas the uneven distribution itself could directly result in measurement error, the hand coupling-induced vibration changes could cause errors in tare mass cancellation. The essential reason for both types of error is that the acceleration measured at one point on the handle may not be the same as that distributed at other locations. Because the cap measurement method that separately measures the DPBRs distributed at the fingers and palm can minimize both types of error, it is the best one among the methods examined in this study. The theory developed in this study can be used to help select, develop, and improve the measurement method for a specific application. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CAD/CAM systems
KW - DISTRIBUTION (Probability theory)
KW - FINITE element method
KW - MECHANICS (Physics)
KW - WEIGHTS & measures
KW - BIOMECHANICS
KW - BIOPHYSICS
N1 - Accession Number: 34530515; Dong, Ren G.; Email Address: rkd6@cdc.gov Welcome, Daniel E. 1 McDowell, Thomas W. 1 Wu, John Z. 1; Affiliation: 1: Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Dec2008, Vol. 318 Issue 4/5, p1313; Subject Term: CAD/CAM systems; Subject Term: DISTRIBUTION (Probability theory); Subject Term: FINITE element method; Subject Term: MECHANICS (Physics); Subject Term: WEIGHTS & measures; Subject Term: BIOMECHANICS; Subject Term: BIOPHYSICS; NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 21p; Document Type: Article
L3 - 10.1016/j.jsv.2008.04.038
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34530515&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - Gen
ID - 9999-16200-000
AN - 9999-16200-000
AU - Drukker, Marjan
AU - Feron, Frans J. M.
AU - Mengelers, Ron
AU - Van Os, Jim
T1 - Informal Social Control Scale--Dutch Version
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2009///
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-16200-000. Other Names: Dutch ISC. Acronyms: ISC. Partial author list: First Author & Affiliation: Drukker, Marjan; Maastricht University, Department Psychiatry and Neuropsychology, Maastricht, Netherlands. Release Date: 20121112. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: Respondents indicate the likelihood that their neighbors can be counted on to intervene in 10 situations using a 5-point scale ('Very likely,' 'likely,' 'neither likely nor unlikely,' 'unlikely,' 'very unlikely'). Items are scored negatively, with higher scores indicating lower levels of social capital.. Language: Dutch; English. Constructs: Informal Social Control; Social Capital; Classification: Social, Group, and Interpersonal Relationships (7600). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Informal Social Control Scale--Dutch Version is to assess willingness to intervene in hypothetical neighborhood-threatening situations in Dutch populations.
AB - Description: The Informal Social Control Scale--Dutch Version (Drukker et al., 2009) is a Dutch translation and adaptation of the Informal Social Control Scale (ISC; Sampson, Raudenbush, & Earls, 1997), which is a collective efficacy scale designed to measure social capital. Specifically, it measures the willingness to intervene in hypothetical neighborhood-threatening situations, for example, children's misbehaving or the opening of a sex club. This scale is conceived in such a way that respondents are independent informants about their neighbors' willingness to intervene. To create the Dutch version, the ISC scale was translated to into Dutch and back-translated into English. To adapt the ISC scale to the Dutch situation, 5 items corresponding to typical Dutch concerns were added to the 5 in the original measure, creating the final 10-item scale. Responses are provided on a 5-point scale. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Informal Social Control Scale--Dutch Version
KW - Test Development
U5 - Informal Social Control Scale--Dutch Version (ISC) [Test Development]Neighborhood socioeconomic and social factors and school achievement in boys and girls. (AN: 2009-05794-005 from PsycINFO) Drukker, Marjan; Feron, Frans J. M.; Mengelers, Ron; Van Os, Jim; Apr, 2009. Source: The Journal of Early Adolescence. 29(2), Sage Publications, US; Apr, 2009; Administration: Paper Age Group: Childhood (birth-12 yrs), School Age (6-12 yrs); Population: Human; Location: Netherlands; Sample: Children Attending Group 8 of the Dutch Primary School Keywords: Informal Social Control Scale--Dutch Version; Test Development; Subjects: Foreign Language Translation; Interpersonal Control; Test Construction;
DO - 10.1037/t16200-000
L3 - Full; Full text; 999916200_full_001.pdf
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DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-16201-000
AN - 9999-16201-000
AU - Drukker, Marjan
AU - Feron, Frans J. M.
AU - Mengelers, Ron
AU - Van Os, Jim
T1 - Social Cohesion and Trust Scale--Dutch Version
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2009///
AD - Drukker, Marjan
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-16201-000. Acronyms: SC&T. Partial author list: First Author & Affiliation: Drukker, Marjan; Maastricht University, Department of Psychiatry and Neuropsychology, Maastricht, Netherlands. Release Date: 20121112. Correction Date: 20151109. Instrument Type: Rating Scale. Test Format: All 11 items are answered using a 5-point, Likert-type scale ranging from strongly agree to strongly disagree. Items are scored negatively, with higher scores indicating lower levels of social capital.. Language: Dutch; English. Constructs: Social Capital; Social Cohesion; Social Trust; Classification: Social, Group, and Interpersonal Relationships (7600). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380).
N2 - Administration Method: Paper
AB - Purpose: The purpose of the Social Cohesion and Trust Scale--Dutch Version is to assess bonds and trust among the residents of a neighborhood in Dutch samples.
AB - Description: The Social Cohesion and Trust Scale--Dutch Version (Drukker et al. 2009) is a Dutch translation of the original Social Cohesion and Trust Scale (SC&T; Sampson, 1997), which measures bonds and trust among the residents of a neighborhood. The 11-item Dutch version was used as a measure of social capital in a study that investigated neighborhood socioeconomic and social factors and school achievement in boys and girls. The original scale was translated into Dutch and back-translated into English. Items are rated on a 5-point scale. (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Social Cohesion and Trust Scale--Dutch Version
KW - Social Capital
KW - Test Development
KW - Neighborhood Resident Attitudes
U5 - Social Cohesion and Trust Scale--Dutch Version (SC&T) [Test Development]Neighborhood socioeconomic and social factors and school achievement in boys and girls. (AN: 2009-05794-005 from PsycINFO) Drukker, Marjan; Feron, Frans J. M.; Mengelers, Ron; Van Os, Jim; Apr, 2009. Source: The Journal of Early Adolescence. 29(2), Sage Publications, US; Apr, 2009; Administration: Paper Age Group: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs), Aged (65 yrs & older); Population: Human; Male; Female; Sample: Maastricht Inhabitants Aged 20 to 65 Years; Location: The Netherlands Keywords: Social Cohesion and Trust Scale--Dutch Version; Social Capital; Test Development; Neighborhood Resident Attitudes; Subjects: Community Attitudes; Foreign Language Translation; Group Cohesion; Rating Scales; Social Capital; Test Construction; Trust (Social Behavior);
DO - 10.1037/t16201-000
L3 - Full; Full text; 999916201_full_001.pdf
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UR - marjan.drukker@sp.unimaas.nl
DP - EBSCOhost
DB - pst
ER -
TY - Gen
ID - 9999-21246-000
AN - 9999-21246-000
AU - Pan, Christopher S.
AU - Chiou, Sharon
AU - Kau, Tsui-Ying
AU - Bhattacharya, Amit
AU - Ammons, Doug
T1 - Rating of Perceived Sense of Postural Instability
JF - PsycTESTS
JO - PsycTESTS
Y1 - 2009///
AD - Pan, Christopher S., National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Rd., MS-G800, Morgantown, West Virginia, United States, 26505
AV - Commercial: No; Permissions: May use for Research/Teaching; Fee: No. Test Items: Yes
N1 - Accession Number: 9999-21246-000. Partial author list: First Author & Affiliation: Pan, Christopher S.; National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia, United States. Release Date: 20130610. Correction Date: 20151109. Instrument Type: Rating Scale. Test Location: Table 2, Page 784. Test Format: Ratings for the 4 items are made on a 5-point scale (0, 0.5, 1, 1.5, 2). Zero score means that the participant perceives low instability and 2 means high stability. The descriptions of the perceived-instability scores are: 0 = low instability, 1 = some instability, 2 = high instability. The sum of the 4 answers defines perceived sense of postural instability (PSOPI).. Language: English. Constructs: Sense of Postural Instability; Classification: Perceptual, Motor, and Sensory Processing (7100). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300).
AB - Purpose: The purpose of the Rating of Perceived Sense of Postural Instability is to assess individual perceptions of sway and instability under a certain physical condition.
AB - Description: The Rating of Perceived Sense of Postural Instability (Pan et al., 2009) was developed in the context of a study that evaluated the potential loss of postural stability associated with the use of stilts in various foot placements. This 4-item, questionnaire-type rating scale assesses perceived sway and instability, which is officially known as perceived sense of postural instability (PSOPI). Responses are provided on a 5-point scale. This measure was found to be in general agreement with the Self-Rating Propensity for Slip Measurement developed by Chiou, Bhattacharya, and Succop (2000). (PsycTESTS Database Record (c) 2015 APA, all rights reserved)
KW - Balance
KW - Rating of Perceived Sense of Postural Instability
KW - Test Development
U5 - Rating of Perceived Sense of Postural Instability [Test Development]Effects of foot placement on postural stability of construction workers on stilts. (AN: 2009-06200-028 from PsycINFO) Pan, Christopher S.; Chiou, Sharon; Kau, Tsui-Ying; Bhattacharya, Amit; Ammons, Doug; Jul, 2009. Source: Applied Ergonomics. 40(4), Elsevier Science, Netherlands; Jul, 2009; Age Group: Adulthood (18 yrs & older); Population: Human; Male; Sample: Construction Workers Keywords: Balance; Rating of Perceived Sense of Postural Instability; Test Development; Subjects: Equilibrium; Posture; Rating Scales; Test Construction;
DO - 10.1037/t21246-000
L3 - Full; Full text; 999921246_full_001.pdf
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=pst&AN=9999-21246-000&site=ehost-live&scope=site
UR - cpan@cdc.gov
DP - EBSCOhost
DB - pst
ER -
TY - JOUR
AU - ORTIZ, Patricia GARCÍA
AU - HANSEN, Steen H.
AU - SHAH, Vinod P.
AU - MENNÉ, Torkil
AU - BENFELDT, Eva
T1 - Impact of Adult Atopic Dermatitis on Topical Drug Penetration: Assessment by Cutaneous Microdialysis and Tape Stripping.
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
Y1 - 2009/01//
VL - 89
IS - 1
M3 - Article
SP - 33
EP - 38
PB - Society for Publication of Acta Dermato-Venereologica
SN - 00015555
AB - Appropriate methodologies for the determination of drug penetration in diseased skin have not yet been established. The aim of this study was to determine the cutaneous penetration of a metronidazole cream formulation in atopic dermatitis, employing dermal microdialysis and tape strip sampling techniques. Non-invasive measuring methods were used for the quantification of the severity of the dermatitis. Skin thickness and the depth of the microdialysis probes in the skin were measured by 20 MHz ultrasound scanning. Metronidazole concentration, sampled by microdialysis, was 2.4-fold higher in the atopic dermatitis compared with uninvolved skin (p<0.001). Tape stripping methodology did not disclose this difference in penetration. Thus, the skin layer of interest and the integrity of the skin barrier should be considered when selecting sampling methodology. Microdialysis sampling is the method of choice whenever the dermis is the target tissue for topical treatment and a skin disease affecting the barrier function is present. [ABSTRACT FROM AUTHOR]
AB - Copyright of Acta Dermato-Venereologica is the property of Society for Publication of Acta Dermato-Venereologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATOPIC dermatitis
KW - ANTISEPTICS
KW - SKIN diseases
KW - METRONIDAZOLE
KW - DERMIS
KW - atopic dermatitis
KW - dermatopharmacokinetics
KW - metronidazole
KW - microdialysis
KW - skin penetration
KW - tape stripping
KW - topical formulations
N1 - Accession Number: 37566160; ORTIZ, Patricia GARCÍA 1; Email Address: patriciagarcia@dadlnet.dk HANSEN, Steen H. 2 SHAH, Vinod P. 3 MENNÉ, Torkil 1 BENFELDT, Eva 1; Affiliation: 1: Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark 2: Department of Pharmaceutics and Analytical Chemistry, Pharmaceutical Faculty, Copenhagen University, Copenhagen, Denmark 3: Office of Pharmaceutical Science, Food and Drug Administration, Rockville, MD, USA; Source Info: 2009, Vol. 89 Issue 1, p33; Subject Term: ATOPIC dermatitis; Subject Term: ANTISEPTICS; Subject Term: SKIN diseases; Subject Term: METRONIDAZOLE; Subject Term: DERMIS; Author-Supplied Keyword: atopic dermatitis; Author-Supplied Keyword: dermatopharmacokinetics; Author-Supplied Keyword: metronidazole; Author-Supplied Keyword: microdialysis; Author-Supplied Keyword: skin penetration; Author-Supplied Keyword: tape stripping; Author-Supplied Keyword: topical formulations; Number of Pages: 6p; Document Type: Article
L3 - 10.2340/00015555-0562
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37566160&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105598962
T1 - Substance use disorder among older adults in the United States in 2020.
AU - Han B
AU - Gfroerer JC
AU - Colliver JD
AU - Penne MA
Y1 - 2009/01//
N1 - Accession Number: 105598962. Language: English. Entry Date: 20090213. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Special Interest: Psychiatry/Psychology. NLM UID: 9304118.
KW - Forecasting
KW - Substance Use Disorders -- Epidemiology -- United States
KW - Substance Use Disorders -- Trends -- United States
KW - Aged
KW - Aged, 80 and Over
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Data Collection, Computer Assisted
KW - Descriptive Statistics
KW - Female
KW - Goodness of Fit Chi Square Test
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - United States
KW - Human
SP - 88
EP - 96
JO - Addiction
JF - Addiction
JA - ADDICTION
VL - 104
IS - 1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - AIMS: This study aimed to project the number of people aged 50 years or older with substance use disorder (alcohol/illicit drug dependence or abuse) in the United States in 2020. DESIGN: Logistic regression models were applied to estimate parameters predicting past-year substance use disorder using the 2002-06 National Survey on Drug Use and Health data. We applied these parameters to the projected US 2020 population to estimate the number of adults aged 50 or older with substance use disorder in 2020. SETTING: Non-institutionalized US residences. PARTICIPANTS: Representative sample of the US civilian, non-institutionalized population. MEASUREMENTS: Substance use disorder is classified based on criteria in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. FINDINGS: Due to the large population size and high substance use rate of the baby-boom cohort, the number of adults aged 50 or older with substance use disorder is projected to double from 2.8 million (annual average) in 2002-06 to 5.7 million in 2020. Increases are projected for all examined gender, race/ethnicity and age groups. CONCLUSIONS: Our estimates provide critical information for policymakers to allocate resources and develop prevention and treatment approaches to address future needs of the US older adult population with substance use disorder.
SN - 0965-2140
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD, USA
U2 - PMID: 19133892.
DO - 10.1111/j.1360-0443.2008.02411.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105598962&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2008-18970-005
AN - 2008-18970-005
AU - Dembo, Richard
AU - Muck, Randolph D.
ED - Leukefeld, Carl G.
ED - Gullotta, Thomas P.
ED - Staton-Tindall, Michelle
ED - Leukefeld, Carl G., (Ed)
ED - Gullotta, Thomas P., (Ed)
ED - Staton-Tindall, Michelle, (Ed)
T1 - Adolescent outpatient treatment.
T2 - Adolescent substance abuse: Evidence-based approaches to prevention and treatment.
T3 - Issues in children's and families' lives; ISSN: 1572-1981 (Print)
Y1 - 2009///
SP - 97
EP - 117
CY - New York, NY, US
PB - Springer Science + Business Media
SN - 1572-1981
SN - 978-0-387-09730-5
SN - 978-0-387-09732-9
N1 - Accession Number: 2008-18970-005. Partial author list: First Author & Affiliation: Dembo, Richard; University of South Florida, FL, US. Release Date: 20090223. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-387-09730-5, Hardcover; 978-0-387-09732-9, PDF. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Drug Rehabilitation; Mental Disorders; Outpatient Treatment. Minor Descriptor: Mental Health. Classification: Psychological Disorders (3210); Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adolescence (13-17 yrs) (200). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - This chapter takes stock of our current state of knowledge about adolescent outpatient drug abuse treatment. We provide estimates of the number of adolescents receiving outpatient treatment in recent years, the specific drugs for which they received treatment, the co-occurrence of mental health issues among treated adolescent drug abusers, and the gap between adolescent treatment need and treatment received. Next, we review key principles that inform effective treatment programs, and, then, drawing on descriptions of evidence-based practices identified by various states, discuss effective approaches to adolescent outpatient treatment. We, then, discuss promising interventions and interventions that do not seem to work. We end with recommendations for new or additional adolescent outpatient treatment services to expand the range of treatment options for drug abusing adolescents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent outpatient treatment
KW - drug abuse treatment
KW - co-occurrence
KW - mental health issues
KW - 2009
KW - Comorbidity
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Mental Disorders
KW - Outpatient Treatment
KW - Mental Health
KW - 2009
DO - 10.1007/978-0-387-09732-9_5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18970-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2015-21476-004
AN - 2015-21476-004
AU - Zito, Julie M.
AU - Safer, Daniel J.
AU - Valluri, Satish
AU - Gardner, James F.
AU - Korelitz, James J.
AU - Mattison, Donald R.
ED - Luby, Joan L.
ED - Riddle, Mark A.
ED - Luby, Joan L., (Ed)
ED - Riddle, Mark A., (Ed)
T1 - Psychotherapeutic medication prevalence in Medicaid-insured preschoolers.
T2 - Advances in preschool psychopharmacology.
Y1 - 2009///
SP - 37
EP - 45
CY - New York, NY, US
PB - Mary Ann Liebert Publishers
SN - 978-1-934854-03-7
N1 - Accession Number: 2015-21476-004. Partial author list: First Author & Affiliation: Zito, Julie M.; Department of Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore, MD, US. Release Date: 20160215. Correction Date: 20160811. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-1-934854-03-7, Hardcover. Language: English. Major Descriptor: Child Psychotherapy; Drug Therapy; Medicaid; Preschool Students; Prescribing (Drugs). Minor Descriptor: Interdisciplinary Treatment Approach; Trends. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40); Outpatient (60). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160). Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9.
AB - Objective: To update knowledge of the prevalence of the use of psychotherapeutic medications in preschoolers with Medicaid insurance as requested by the Best Pharmaceuticals for Children Act of 2002 (BPCA). Method: Prescription, enrollment, and outpatient visit data from 7 state Medicaid programs were used to identify 274,518 youths continuously enrolled in 2001 and aged 2 to 4 on January 1, 2001. Annual prevalence of use was defined as one or more dispensed prescriptions for a psychotherapeutic medication and adjusted for anticonvulsant and anxiolytic/sedative/hypnotic use according to ICD-9 diagnostic groupings. Prevalence ratios adjusted for age, race/ethnicity, and gender were estimated. Results: 2.30% (CI = 2.24, 2.36) of preschoolers received one or more dispensings for a psychotherapeutic medication in 2001, approximately doubling the usage of comparable youth from 2 other state Medicaid programs studied in 1995. Boys were 2.4 times more likely than girls to receive psychotherapeutic medication. Whites were 4 times more likely than Hispanics and twice as likely as Blacks to receive medication for psychiatric or behavioral conditions. Since the mid-1990s, usage increased, especially for atypical antipsychotics and antidepressants. The prominent use of anticonvulsants (78.8%) and anxiolytic/sedative/hypnotic drugs (91.4%) in those with no psychiatric diagnosis, but with other medical diagnoses, shows that much use therein reflects treatment for seizures, rather than mood stabilization, and for minor medical conditions, rather than psychiatric disorders. Conclusion: Preschool psychotherapeutic medication use increased across ages 2 to 4 for stimulants, antipsychotics, and antidepressants, reflecting use for psychiatric/behavioral disorders. However, the use of anxiolytic/sedative/hypnotics and anticonvulsants was more stable across these years, suggesting medical usage. Additional research to assess the benefits and risks of psychotherapeutic drugs is needed, particularly when such usage is off-label for both psychiatric and nonpsychiatric conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotherapeutics
KW - medication prevalence
KW - Medicaid
KW - health insurance
KW - preschoolers
KW - 2009
KW - Child Psychotherapy
KW - Drug Therapy
KW - Medicaid
KW - Preschool Students
KW - Prescribing (Drugs)
KW - Interdisciplinary Treatment Approach
KW - Trends
KW - 2009
U1 - Sponsor: National Institute of Child Health and Human Development, US. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-21476-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2009-17999-018
AN - 2009-17999-018
AU - Sauter, Steven L.
AU - Streit, Jessica M.
AU - Hanseman, Dennis J.
ED - Czaja, Sara J.
ED - Sharit, Joseph
ED - Czaja, Sara J., (Ed)
ED - Sharit, Joseph, (Ed)
T1 - Work organization and health in an aging workforce: Observations from the NIOSH quality of life survey.
T2 - Aging and work: Issues and implications in a changing landscape.
Y1 - 2009///
SP - 259
EP - 393
CY - Baltimore, MD, US
PB - Johns Hopkins University Press
SN - 0-8018-9273-2
SN - 978-0-8018-9273-8
N1 - Accession Number: 2009-17999-018. Partial author list: First Author & Affiliation: Sauter, Steven L.; Division of Applied Research and Technology, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20100301. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8018-9273-2, Hardcover; 978-0-8018-9273-8, Hardcover. Language: English. Major Descriptor: Age Differences; Aging; Health; Organizations; Personnel. Minor Descriptor: Family Work Relationship; Occupational Exposure; Occupational Safety; Risk Factors; Well Being; Working Conditions; Work-Life Balance. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 135.
AB - This chapter goes beyond the issue addressed by Finnish investigators (i.e., effects of work organization on work capacity and health in aging workers) to focus on an issue that is equally important from the standpoint of work design and health protection for older workers: Do older workers differ somehow from younger workers in terms of risks posed by work organization factors? Two possibilities exist, and neither has been subjected to systematic study. First is the idea that work organization exposures may vary as a function of age, creating different risk profiles for older and younger workers. Second is the vulnerability hypothesis: that older workers may differ from younger workers in their capacity to respond to stressful situations related to work. This latter possibility is aptly framed by Griffiths (2007, 34), who commented that 'key to our concerns for older workers, is that there may be specific characteristics of work design and management that are experienced as particularly problematic by older workers and therefore are likely to be particularly stressful for them.' This chapter examines these two possibilities further. We begin with a summary of findings from the literature on comparative levels of subjective wellbeing, including job stress, between older and younger workers. Age differences in these outcomes might indicate age differences in risks posed by the organization of work. Next, we report on findings from the much smaller body of research that directly investigates both age gradients in work organization exposures and age differentials in the effects of work organization on health and safety outcomes. We then describe the results of new analyses we have conducted using a nationally representative workforce sample to further explore these types of effects, including analyses of (1) age differences in a variety of health-related outcomes, (2) age differences in work organization exposures and work-life balance indicators, and (3) age differences in the relationship of these exposure and balance factors with health-related outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - work organization
KW - health
KW - aging workforce
KW - risk profiles
KW - well being
KW - age differences
KW - safety
KW - work-life balance
KW - organization exposures
KW - 2009
KW - Age Differences
KW - Aging
KW - Health
KW - Organizations
KW - Personnel
KW - Family Work Relationship
KW - Occupational Exposure
KW - Occupational Safety
KW - Risk Factors
KW - Well Being
KW - Working Conditions
KW - Work-Life Balance
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17999-018&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2009-17999-017
AN - 2009-17999-017
AU - Grosch, James W.
AU - Pransky, Glenn S.
ED - Czaja, Sara J.
ED - Sharit, Joseph
ED - Czaja, Sara J., (Ed)
ED - Sharit, Joseph, (Ed)
T1 - Safety and health issues for an aging workforce.
T2 - Aging and work: Issues and implications in a changing landscape.
Y1 - 2009///
SP - 334
EP - 358
CY - Baltimore, MD, US
PB - Johns Hopkins University Press
SN - 0-8018-9273-2
SN - 978-0-8018-9273-8
N1 - Accession Number: 2009-17999-017. Partial author list: First Author & Affiliation: Grosch, James W.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, OH, US. Release Date: 20100301. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8018-9273-2, Hardcover; 978-0-8018-9273-8, Hardcover. Language: English. Major Descriptor: Aging; Health; Occupational Safety; Personnel. Classification: Working Conditions & Industrial Safety (3670); Gerontology (2860). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 25.
AB - In the workplace, the goal of continuing to work while remaining healthy and productive has received increasing attention in recent years (e.g., Ilmarinen, 1999; Rix, 2001; National Research Council, 2004). Much of the interest in this issue stems from the fact that the proportion of all workers who are over 55 is projected to increase twice as fast as their younger counterparts over the next decade. These older workers can be expected to spend more of their lives working due to increasing longevity and to both a decrease and a postponement of retirement benefits (Hayward, Grady, and McLaughlin, 1988). Despite much interest in maintaining older workers in the workforce, there is relatively little research on the unique health and safety issues of older workers, how they are affected by work organization, and how these issues affect occupational injury and work performance. Although older workers are more likely to have chronic health conditions and physical limitations, these factors are not directly related to decreased work performance. The causes and consequences of work injury in older persons are complex and may differ from those in younger workers (Pransky, Santosh, Lee, and Webster, 2006). Although there is considerable information on age-related differences in various types of work injuries, little is known about the most effective methods for rehabilitation and prevention of re-injury in older workers (DeZwart, Frings-Dresen, and VanDijk, 1995). This chapter reviews the state of knowledge in this area, identifies interventions that address workplace health and safety in older workers, and suggests future research directions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - safety issues
KW - health issues
KW - aging workforce
KW - 2009
KW - Aging
KW - Health
KW - Occupational Safety
KW - Personnel
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17999-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105293004
T1 - Comparative analysis of cell culture and prediction algorithms for phenotyping of genetically diverse HIV-1 strains from Cameroon.
AU - Ragupathy V
AU - Zhao J
AU - Wang X
AU - Wood O
AU - Lee S
AU - Burda S
AU - Nyambi P
AU - Hewlett I
Y1 - 2009/01//
N1 - Accession Number: 105293004. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; UK & Ireland. Grant Information: National Heart, Lung and Blood Institute (IAA-NHLBI, BYI-HB-5026-01). NLM UID: 101237921.
KW - HIV Infections -- Familial and Genetic
KW - HIV-1
KW - Models, Statistical
KW - Phenotype
KW - Adult
KW - Antiviral Agents -- Adverse Effects
KW - Antiviral Agents -- Therapeutic Use
KW - Cameroon
KW - Comparative Studies
KW - Drug Resistance, Microbial
KW - Female
KW - Funding Source
KW - Human
KW - Male
KW - Middle Age
KW - Mutation
KW - RNA
KW - Specimen Handling
KW - Viral Load
SP - 4p
EP - 4p
JO - AIDS Research & Therapy
JF - AIDS Research & Therapy
JA - AIDS RES THER
VL - 6
PB - BioMed Central
SN - 1742-6405
AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD
U2 - PMID: 19939258.
DO - 10.1186/1742-6405-6-27
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105293004&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105461284
T1 - Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims.
AU - Kim JY
AU - Kwon O
Y1 - 2009/01//
N1 - Accession Number: 105461284. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Nutrition. NLM UID: 0376027.
KW - Antineoplastic Agents -- Administration and Dosage
KW - Food Labeling
KW - Garlic
KW - Medical Practice, Evidence-Based -- Methods
KW - Neoplasms -- Prevention and Control
KW - Plant Extracts -- Administration and Dosage
KW - Antineoplastic Agents -- Pharmacodynamics
KW - Female
KW - Health Food
KW - Male
KW - Neoplasms -- Epidemiology
KW - Plant Extracts -- Pharmacodynamics
KW - Risk Factors
KW - United States Food and Drug Administration
KW - United States
KW - Human
SP - 257
EP - 264
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 89
IS - 1
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - BACKGROUND: Numerous animal and in vitro studies provided evidence for a relation between garlic intake and cancer risk reduction. Several studies also reported an inverse association in humans. However, no claims have been made about garlic intake and cancer risk reduction with respect to food labeling. OBJECTIVE: The objective of this study was to evaluate the scientific evidence for garlic intake with respect to the risk of different types of cancer using the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. DESIGN: Literature searches were conducted by using the Medline and EMBASE databases for the period 1955-2007 with search terms Allium sativum, vegetables, diet, and nutrition in combination with cancer, neoplasm, and individual cancers. The search was limited to human studies published in English and Korean. RESULTS: With the use of the US Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims, 19 human studies were identified and reviewed to evaluate the strength of the evidence that supports a relation between garlic intake and reduced risk of different cancers with respect to food labeling. CONCLUSIONS: There was no credible evidence to support a relation between garlic intake and a reduced risk of gastric, breast, lung, or endometrial cancer. Very limited evidence supported a relation between garlic consumption and reduced risk of colon, prostate, esophageal, larynx, oral, ovary, or renal cell cancers. Copyright © 2009 American Society for Nutrition
SN - 0002-9165
AD - Division of Nutrition and Functional Food Standards, Korea Food and Drug Administration, Seoul, Korea.
U2 - PMID: 19056580.
DO - 10.3945/ajcn.2008.26142
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105461284&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lawson, Christina C.
AU - Whelan, Elizabeth A.
AU - Hibert, Eileen N.
AU - Grajewski, Barbara
AU - Spiegelman, Donna
AU - Rich-Edwards, Janet W.
T1 - Occupational factors and risk of preterm birth in nurses
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2009/01//
VL - 200
IS - 1
M3 - Article
SP - 51
EP - 51
SN - 00029378
AB - Objective: We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses'' Health Study II. Study Design: Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity. Results: Part-time work (≤ 20 hours a week) was associated with a lower risk of preterm birth [RR, 0.7; 95% confidence interval [CI], 0.6-0.9]. Working nights was associated only with early preterm birth (< 32 weeks of gestation) (RR, 3.0; 95% CI, 1.4-6.2). Although based on only 11 exposed preterm cases, self-reported exposure to sterilizing agents was associated with an increased risk (RR, 1.9; 95% CI, 1.1-3.4). Conclusion: These data suggest that night work may be related to early but not late preterm birth, whereas physically demanding work did not strongly predict risk. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Obstetrics & Gynecology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREMATURE labor -- Risk factors
KW - NURSES -- Health
KW - REGRESSION analysis
KW - CONFIDENCE intervals
KW - WORKING hours
KW - CHEMICALS -- Physiological effect
KW - X-rays -- Physiological effect
KW - NIGHT work
KW - nurses
KW - occupational exposure
KW - pregnancy
KW - preterm birth
KW - work schedule tolerance
N1 - Accession Number: 36056659; Lawson, Christina C. 1; Email Address: clawson@cdc.gov; Whelan, Elizabeth A. 1; Hibert, Eileen N. 2; Grajewski, Barbara 1; Spiegelman, Donna 3,4; Rich-Edwards, Janet W. 3,5; Source Information: Jan2009, Vol. 200 Issue 1, p51; Subject: PREMATURE labor -- Risk factors; Subject: NURSES -- Health; Subject: REGRESSION analysis; Subject: CONFIDENCE intervals; Subject: WORKING hours; Subject: CHEMICALS -- Physiological effect; Subject: X-rays -- Physiological effect; Subject: NIGHT work; Author-Supplied Keyword: nurses; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: pregnancy; Author-Supplied Keyword: preterm birth; Author-Supplied Keyword: work schedule tolerance; Number of Pages: 1p; Document Type: Article
L3 - 10.1016/j.ajog.2008.08.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=36056659&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105622019
T1 - Occupational factors and risk of preterm birth in nurses.
AU - Lawson CC
AU - Whelan EA
AU - Hibert EN
AU - Grajewski B
AU - Spiegelman D
AU - Rich-Edwards JW
AU - Lawson, Christina C
AU - Whelan, Elizabeth A
AU - Hibert, Eileen N
AU - Grajewski, Barbara
AU - Spiegelman, Donna
AU - Rich-Edwards, Janet W
Y1 - 2009/01//
N1 - Accession Number: 105622019. Language: English. Entry Date: 20090213. Revision Date: 20161116. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Obstetric Care; Women's Health. Grant Information: R01 CA050385/CA/NCI NIH HHS/United States. NLM UID: 0370476.
KW - Childbirth, Premature -- Etiology
KW - Nurses
KW - Occupational Diseases -- Etiology
KW - Occupational Exposure -- Adverse Effects
KW - Adult
KW - Female
KW - Odds Ratio
KW - Pregnancy Trimester, First
KW - Pregnancy
KW - Prospective Studies
KW - Risk Factors
KW - Human
SP - 51.e1
EP - 8
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
JA - AM J OBSTET GYNECOL
VL - 200
IS - 1
CY - New York, New York
PB - Elsevier Science
AB - Objective: We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II.Study Design: Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity.Results: Part-time work ( 75%. Such findings suggest that CD147–cyclophilin interactions might contribute to the pathogenesis of RA by promoting the recruitment of leucocytes into joint tissues. [ABSTRACT FROM AUTHOR]
AB - Copyright of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLYCOPROTEINS
KW - ARTHRITIS
KW - PEPTIDYLPROLYL isomerase
KW - METALLOPROTEINASES
KW - NEUTROPHILS
KW - IMMUNOGLOBULINS
KW - autoimmunity
KW - chemokines
KW - collagen-induced arthritis
KW - inflammation
KW - rheumatoid arthritis
N1 - Accession Number: 35604187; Damsker, Jesse M. 1 Okwumabua, Ifeanyi 1 Pushkarsky, Tatiana 1 Arora, Kamalpreet 2 Bukrinsky, Michael I. 1 Constant, Stephanie L. 1; Email Address: mtmslc@gwumc.edu; Affiliation: 1: Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA 2: Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Jan2009, Vol. 126 Issue 1, p55; Subject Term: GLYCOPROTEINS; Subject Term: ARTHRITIS; Subject Term: PEPTIDYLPROLYL isomerase; Subject Term: METALLOPROTEINASES; Subject Term: NEUTROPHILS; Subject Term: IMMUNOGLOBULINS; Author-Supplied Keyword: autoimmunity; Author-Supplied Keyword: chemokines; Author-Supplied Keyword: collagen-induced arthritis; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: rheumatoid arthritis; Number of Pages: 8p; Illustrations: 5 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2567.2008.02877.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35604187&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Honma, Takeshi
AU - Suda, Megumi
AU - Miyagawa, Muneyuki
AU - Rui-Sheng Wang
AU - Kobayashi, Kenichi
AU - Sekiguchi, Soichiro
T1 - Alteration of Brain Neurotransmitters in Female Rat Offspring Induced by Prenatal Administration of 16 and 64 mg/kg of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153).
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/01//
VL - 47
IS - 1
M3 - Article
SP - 11
EP - 21
SN - 00198366
AB - The article presents a study which examines the effects of inducing PCB153, a non-coplanar, in female rat offspring during pregnancy. The PCB153 was orally administered to pregnant-Dawley rats. The study reveals that PCB153 can cause alterations in brain neurotransmitters such as the reduction of dopamine neurons in the brain of dams.
KW - Polychlorinated biphenyls
KW - Rats as laboratory animals
KW - Pregnancy
KW - Neurotransmitters
KW - Dopamine
KW - Acetylcholine
KW - Brain
KW - IGS rat
KW - Norepinephrine
KW - Offspring
KW - PCB153
KW - Prenatal exposure
KW - Serotonin
N1 - Accession Number: 43058516; Honma, Takeshi 1,2; Suda, Megumi 1; Miyagawa, Muneyuki 1; Rui-Sheng Wang 1; Kobayashi, Kenichi 1; Sekiguchi, Soichiro 1; Affiliations: 1: Department of Health Effects Research, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; 2: Japan Association for Working Environment Measurement, 4-4-5 Shiba, Minato-ku, Tokyo 108-8372, Japan; Issue Info: 2009, Vol. 47 Issue 1, p11; Thesaurus Term: Polychlorinated biphenyls; Subject Term: Rats as laboratory animals; Subject Term: Pregnancy; Subject Term: Neurotransmitters; Subject Term: Dopamine; Author-Supplied Keyword: Acetylcholine; Author-Supplied Keyword: Brain; Author-Supplied Keyword: IGS rat; Author-Supplied Keyword: Norepinephrine; Author-Supplied Keyword: Offspring; Author-Supplied Keyword: PCB153; Author-Supplied Keyword: Prenatal exposure; Author-Supplied Keyword: Serotonin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 2 Charts, 9 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Otsuka, Yasumasa
AU - Sasaki, Takeshi
AU - Iwasaki, Kenji
AU - Mori, Ippei
T1 - Working Hours, Coping Skills, and Psychological Health in Japanese Daytime Workers.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/01//
VL - 47
IS - 1
M3 - Article
SP - 22
EP - 32
SN - 00198366
AB - The article presents a study which examines the relationship between working hours, coping skills, and psychological health among Japanese daytime workers. The study uses self-administered questionnaires as a tool for assessing the health status of Japanese daytime workers. It revealed that fatigue and concentration/activity levels are associated with working hours. It suggests that high levels of instrumental support and positive reframing can reduce the negative effects of long working hours.
KW - HEALTH
KW - RESEARCH
KW - Japanese
KW - Working hours
KW - Life skills
KW - Questionnaires
KW - Fatigue
KW - Japan
KW - Concentration/activity levels
KW - Coping skills
KW - Negative emotions
KW - Working hours
N1 - Accession Number: 43058517; Otsuka, Yasumasa 1,2; Sasaki, Takeshi 2; Iwasaki, Kenji 2; Mori, Ippei 2; Affiliations: 1: Department of Psychology, Hiroshima University Graduate School of Education, 1-1-1 Kagamiyama, Higashi-hiroshima 739-8524, Japan; 2: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2009, Vol. 47 Issue 1, p22; Thesaurus Term: HEALTH; Thesaurus Term: RESEARCH; Subject Term: Japanese; Subject Term: Working hours; Subject Term: Life skills; Subject Term: Questionnaires; Subject Term: Fatigue; Subject: Japan; Author-Supplied Keyword: Concentration/activity levels; Author-Supplied Keyword: Coping skills; Author-Supplied Keyword: Negative emotions; Author-Supplied Keyword: Working hours; Number of Pages: 11p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ojima, Jun
T1 - Tracer Gas Evaluations of Push-Pull Ventilation System Performance.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/01//
VL - 47
IS - 1
M3 - Article
SP - 94
EP - 96
SN - 00198366
AB - The article presents a study which evaluates the capture efficiency of a push-pull ventilation system of tracer gas method. The study uses a dummy worker and a cross draft and were placed in the ventilation zone. It reveals that uniform flow of a push-pull ventilation system will reduce its performance system.
KW - Ventilation
KW - Buildings -- Environmental engineering
KW - Air conditioning
KW - Dampness in buildings
KW - Coal gas
KW - Capture efficiency
KW - Push-pull ventilation system
KW - Tracer gas
N1 - Accession Number: 43058526; Ojima, Jun 1; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, kawasaki 214-8585, Japan; Issue Info: 2009, Vol. 47 Issue 1, p94; Thesaurus Term: Ventilation; Thesaurus Term: Buildings -- Environmental engineering; Thesaurus Term: Air conditioning; Thesaurus Term: Dampness in buildings; Thesaurus Term: Coal gas; Author-Supplied Keyword: Capture efficiency; Author-Supplied Keyword: Push-pull ventilation system; Author-Supplied Keyword: Tracer gas; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 334512 Automatic Environmental Control Manufacturing for Residential, Commercial, and Appliance Use; Number of Pages: 3p; Illustrations: 1 Black and White Photograph, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Heudorf, U.
AU - Neitzert, V.
AU - Spark, J.
T1 - Particulate matter and carbon dioxide in classrooms – The impact of cleaning and ventilation
JO - International Journal of Hygiene & Environmental Health
JF - International Journal of Hygiene & Environmental Health
Y1 - 2009/01//
VL - 212
IS - 1
M3 - Article
SP - 45
EP - 55
SN - 14384639
AB - Abstract: The objective of the study was to measure the indoor air quality in classrooms with special emphasis on particulate matter (PM 10) and carbon dioxide (CO2) and the impact of cleaning and ventilation. Material and method: PM 10 was analysed via gravimetric method and by laser beam technology. CO2 was analysed by infrared sensors. Measurements were collected for 3 weeks; first week: “normal” cleaning (twice a week) and ventilation; second week: intensified cleaning (five times a week); third week: intensified cleaning and intensified ventilation. Results: Levels of PM 10 in the classrooms during the 3 weeks were 69±19μg/m3 and they were dominated by occupancy and the persons’ activity. Intensified cleaning showed a significant decrease in all classrooms (79±22 to 64±15μg/m3). The effect of ventilation on levels of PM10 was inconsistent – levels of CO2 were very high in all schools and could be diminished by intensified ventilation (mean 1459 to 1051ppm). Conclusion: Although further investigation is needed to study detailed characteristics of the PM 10 (size distribution, chemical identity) the data are sufficient to improve the cleaning and the ventilation in schools. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Hygiene & Environmental Health is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICULATE matter
KW - CARBON dioxide -- Environmental aspects
KW - CLEANING
KW - VENTILATION
KW - INDOOR air quality
KW - CLASSROOMS
KW - LASER beams
KW - Air quality
KW - Carbon dioxide
KW - Cleaning
KW - Particulate matter PM 10
KW - Schools
KW - Ventilation
N1 - Accession Number: 35771241; Heudorf, U. 1; Email Address: ursel.heudorf@stadt-frankfurt.de Neitzert, V. 2; Email Address: volker.neitzert@tuev-sued.de Spark, J. 3; Email Address: josef.spark@institut-fresenius.de; Affiliation: 1: Public Health Service of the City of Frankfurt/M., Braubachstr. 18-22, D-60311 Frankfurt, Germany 2: TÜV Industry Service GmbH, Environment Service, Mergenthalerallee 27, D-65760 Eschborn, Germany 3: Consumer Testing Service, SGS Institut Fresenius GmbH, Im Maisel 14, D-65232 Taunusstein, Germany; Source Info: Jan2009, Vol. 212 Issue 1, p45; Subject Term: PARTICULATE matter; Subject Term: CARBON dioxide -- Environmental aspects; Subject Term: CLEANING; Subject Term: VENTILATION; Subject Term: INDOOR air quality; Subject Term: CLASSROOMS; Subject Term: LASER beams; Author-Supplied Keyword: Air quality; Author-Supplied Keyword: Carbon dioxide; Author-Supplied Keyword: Cleaning; Author-Supplied Keyword: Particulate matter PM 10; Author-Supplied Keyword: Schools; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; NAICS/Industry Codes: 561720 Janitorial Services; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ijheh.2007.09.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105619236
T1 - Particulate matter and carbon dioxide in classrooms - The impact of cleaning and ventilation.
AU - Heudorf U
AU - Neitzert V
AU - Spark J
Y1 - 2009/01//
N1 - Accession Number: 105619236. Language: English. Entry Date: 20090320. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health. Special Interest: Public Health. NLM UID: 100898843.
KW - Air Pollution, Indoor -- Analysis
KW - Carbon Dioxide -- Analysis
KW - Particulate Matter -- Analysis
KW - Schools
KW - Ventilation -- Methods
KW - Dust -- Analysis
KW - Environmental Pollution -- Methods
KW - Germany
KW - Human
SP - 45
EP - 55
JO - International Journal of Hygiene & Environmental Health
JF - International Journal of Hygiene & Environmental Health
JA - INT J HYG ENVIRON HEALTH
VL - 212
IS - 1
CY - London,
PB - Elsevier GmbH, Urban & Fischer Verlag
SN - 1438-4639
AD - Public Health Service of the City of Frankfurt/M., Braubachstr. 18-22, D-60311 Frankfurt, Germany.
U2 - PMID: 18155960.
DO - 10.1016/j.ijheh.2007.09.011
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Xu, X.S.
AU - Welcome, D.E.
AU - McDowell, T.W.
AU - Warren, C.
AU - Dong, R.G.
T1 - An investigation on characteristics of the vibration transmitted to wrist and elbow in the operation of impact wrenches
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2009/01//
VL - 39
IS - 1
M3 - Article
SP - 174
EP - 184
SN - 01698141
AB - Abstract: To help assess the risk of the vibration exposure during impact wrench operation and to develop a convenient and effective method to monitor and control the exposure, this study aims to investigate the characteristics of the vibrations transmitted to the wrist and elbow in the operation and to evaluate the on-the-wrist and on-the-elbow vibration measurement methods. Six subjects participated in the experiment. Each of them used 15 impact wrenches on a simulated workstation. Tri-axial accelerations at three locations (tool handle, wrist, and elbow) and the tool effective torques were measured and used in the evaluations. Results confirm that the severity of the vibration exposure generally depends on tool and individual, and that the vibrations measured at wrist and elbow reflect the influences of both factors. This study also found that the accelerations measured at the wrist and elbow are correlated with the ISO frequency-weighted tool acceleration. The fundamental resonance of the hand-arm system in the range of 16–50Hz is well reflected in the vibration measured at the wrist. The results also demonstrate that vibration exposure duration can be reliably detected from the wrist vibration data. Moreover, the wrist vibration is suggestively correlated with the torque of the pneumatic impact wrenches. These findings suggest that the measurement of the wrist vibration can be used as an alternative approach to perform the exposure risk assessment and to monitor and control the exposures in the operation of the impact wrenches. Relevance to Industry: Impact wrenches or nut runners with impact action are widely and intensively used in automobile manufacturing and repair, which could generate significant vibration and require forceful actions. Prolonged, intensive exposure to both vibration and forceful actions could result in hand-arm vibration syndrome and carpal tunnel syndrome. The results of this study suggest that the on-the-wrist vibration measurement is a reasonable alternative approach for quantifying and assessing the exposures, which provides a theoretical base for developing a convenient and effective method for monitoring and controlling the combined exposures. The results of this study also suggest that the on-the-wrist method can also be used at workplaces to perform screening tests of the tools with dominant vibration frequencies similar to those of the impact wrenches and to evaluate the effectiveness of the anti-vibration devices used with such tools. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Wrenches
KW - Nut runners & setters
KW - Torque wrenches
KW - Tools
KW - Hand-arm vibration
KW - Hand-transmitted vibration
KW - Impact wrench
KW - Nut runner
KW - Wrist
N1 - Accession Number: 35934713; Xu, X.S.; Email Address: xxu1@cdc.gov; Welcome, D.E. 1; McDowell, T.W. 1; Warren, C. 1; Dong, R.G. 1; Affiliations: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Jan2009, Vol. 39 Issue 1, p174; Subject Term: Wrenches; Subject Term: Nut runners & setters; Subject Term: Torque wrenches; Subject Term: Tools; Author-Supplied Keyword: Hand-arm vibration; Author-Supplied Keyword: Hand-transmitted vibration; Author-Supplied Keyword: Impact wrench; Author-Supplied Keyword: Nut runner; Author-Supplied Keyword: Wrist; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 444130 Hardware Stores; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.ergon.2008.05.006
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Veldhuijzen, Irene K.
AU - van Driel, Harold F.
AU - Vos, Dieuwke
AU - de Zwart, Onno
AU - van Doornum, Gerard J.J.
AU - de Man, Robert A.
AU - Richardus, Jan Hendrik
T1 - Viral hepatitis in a multi-ethnic neighborhood in the Netherlands: results of a community-based study in a low prevalence country
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
Y1 - 2009/01//
VL - 13
IS - 1
M3 - Article
SP - e9
EP - e13
SN - 12019712
AB - Summary: Objectives: The prevalence of viral hepatitis varies worldwide. Although the prevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) infection is generally low in Western countries, pockets of higher prevalence may exist in areas with large immigrant populations. The aim of this study was to obtain further information on the prevalence of viral hepatitis in a multi-ethnic area in the Netherlands. Methods: We conducted a community-based study in a multi-ethnic neighborhood in the city of Rotterdam, the Netherlands, including both native Dutch and migrant participants, who were tested for serological markers of hepatitis A, hepatitis B, and hepatitis C infection. Results: Markers for hepatitis A infection were present in 68% of participants. The prevalence of hepatitis B core antibodies (anti-HBc), a marker for previous or current infection, was 20% (58/284). Prevalence of hepatitis A and B varied by age group and ethnicity. Two respondents (0.7%) had chronic HBV infection. The prevalence of hepatitis C was 1.1% (3/271). High levels of isolated anti-HBc were found. Conclusions: We found a high prevalence of (previous) viral hepatitis infections. This confirms previous observations in ethnic subgroups from a national general population study and illustrates the high burden of viral hepatitis in areas with large immigrant populations. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Infectious Diseases is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL hepatitis
KW - HEPATITIS B virus
KW - HEPATITIS A
KW - NETHERLANDS
KW - Hepatitis A
KW - Hepatitis B
KW - Hepatitis C
KW - Immigrants
KW - Isolated anti-HBc
KW - The Netherlands
KW - Viral hepatitis
N1 - Accession Number: 35928929; Veldhuijzen, Irene K. 1,2; Email Address: veldhuijzeni@ggd.rotterdam.nl van Driel, Harold F. 1 Vos, Dieuwke 1 de Zwart, Onno 1,3 van Doornum, Gerard J.J. 4 de Man, Robert A. 2 Richardus, Jan Hendrik 1,3; Affiliation: 1: Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, PO Box 70032, 3000 LP Rotterdam, the Netherlands 2: Department of Gastroenterology and Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands 3: Department of Public Health, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands 4: Department of Virology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands; Source Info: Jan2009, Vol. 13 Issue 1, pe9; Subject Term: VIRAL hepatitis; Subject Term: HEPATITIS B virus; Subject Term: HEPATITIS A; Subject Term: NETHERLANDS; Author-Supplied Keyword: Hepatitis A; Author-Supplied Keyword: Hepatitis B; Author-Supplied Keyword: Hepatitis C; Author-Supplied Keyword: Immigrants; Author-Supplied Keyword: Isolated anti-HBc; Author-Supplied Keyword: The Netherlands; Author-Supplied Keyword: Viral hepatitis; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.ijid.2008.05.1224
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hart, Mark E.
AU - Hart, Morgan J.
AU - Roop, Anna J.
T1 - Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species.
JO - International Journal of Microbiology
JF - International Journal of Microbiology
Y1 - 2009/01//
M3 - Article
SP - 1
EP - 8
SN - 1687918X
AB - Hyaluronidases degrade hyaluronic acid, amajor polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. The purpose of the present study was to determine the prevalence of hyaluronidase among clinical strains of Staphylococcus aureus and among other Staphylococcus species. Spent media and chromosomal DNA were assessed for hyaluronidase activity and the absence or presence of a hyaluronidase gene (hysA) by Southern analysis, respectively. All S. aureus strains examined exhibited at least one hybridizing band (half of the strains exhibited two or more hybridizing bands) when probed for hysA and all but three of these strains produced hyaluronidase. In contrast, none of the type strains of 19 other species exhibited either hyaluronidase activity or hybridizing bands when probed for hysA. These data support the hypothesis that among members of the Staphylococcus genus only strains of S. aureus possess the enzyme hyaluronidase. This would suggest that hyaluronidase represents yet another potential virulence factor employed by S. aureus to cause disease and may represent a diagnostically important characteristic for distinguishing S. aureus from other members of this genus. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Microbiology is the property of Hindawi Publishing Corporation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYALURONIC acid
KW - POLYSACCHARIDES
KW - VIRULENCE (Microbiology)
KW - BACTERIA
KW - STAPHYLOCOCCAL diseases
KW - GRAM-positive bacteria
KW - GRAM-negative bacterial diseases
KW - GRAM-positive bacterial infections
KW - HYBRIDIZATION
N1 - Accession Number: 52869716; Hart, Mark E. 1,2; Email Address: mark.hart@fda.hhs.gov Hart, Morgan J. 3 Roop, Anna J. 3; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA 3: Department of Biology, Ouachita Baptist University, Arkadelphia, AR 71998, USA; Source Info: 2009, p1; Subject Term: HYALURONIC acid; Subject Term: POLYSACCHARIDES; Subject Term: VIRULENCE (Microbiology); Subject Term: BACTERIA; Subject Term: STAPHYLOCOCCAL diseases; Subject Term: GRAM-positive bacteria; Subject Term: GRAM-negative bacterial diseases; Subject Term: GRAM-positive bacterial infections; Subject Term: HYBRIDIZATION; Number of Pages: 8p; Illustrations: 4 Color Photographs, 1 Chart; Document Type: Article
L3 - 10.1155/2009/614371
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lopes, Pedro E. M.
AU - Demchuk, Eugene
AU - Mackerell Jr, Alexander D.
T1 - Reconstruction of the (011) surface on α-quartz: A semiclassical Ab initio molecular dynamics study.
JO - International Journal of Quantum Chemistry
JF - International Journal of Quantum Chemistry
Y1 - 2009/01//
VL - 109
IS - 1
M3 - Article
SP - 50
EP - 64
SN - 00207608
AB - Ab initio molecular dynamics simulations have been performed on the (011) surface of α-quartz at room-temperature using density functional theory. Pristine surface was obtained by homolytic fracture of α-quartz crystal, leaving exposed SiO· radicals, following which the surface was allowed to spontaneously reconstruct during the simulation. Reconstruction events occurred at different timings but in most cases produced similar geometries. The most common motif consisted of a fused seven-member ring. Formation of this structure proceeded through reaction of two adjacent O· radicals, followed by linking of one of the reactive O· with a nearby silicon. Other structures, like Si2O2, were also observed. In the newly formed structures some of the silicon atoms had pentacoordinated geometry, usually distorted between pure bipyramidal, trigonal, and square pyramidal. In a few cases oxygen atoms also became tricoordinated. Formation of new bonds was investigated by analyzing the electronic structure of the system along the reaction path, and specifically the localization of unpaired electrons was deduced from the spin-density. Because most reactions involved triplet → singlet transitions, a time-dependent density functional theory was used to determine the crossing point of the two potential energy surfaces. Plotted density of states was also used to compare the electronic structures of the initial and reconstructed surfaces. Reconstruction originated new states from O-px and O-pz orbitals. Stability analysis of the reconstructed surface was performed at the PBE level and 7-member rings were found to be more stable than fused rings with pentacoordinated silicon. Hypervalent silicon and oxygen atoms were also found to exist. Nevertheless, specialization of (011) surface appears to be less reactive compared to (001), which suggests a lesser toxicity of rhombohedral form on crystalline silica. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Quantum Chemistry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR dynamics
KW - DENSITY functionals
KW - SURFACE chemistry
KW - QUARTZ
KW - SILICOSIS
KW - density functional theory
KW - molecular dynamics
KW - quartz
KW - silica toxicity
KW - silicosis
KW - surfaces
N1 - Accession Number: 34962244; Lopes, Pedro E. M. 1,2; Email Address: lopes@outerbanks.umaryland.edu Demchuk, Eugene 1,3,4 Mackerell Jr, Alexander D. 2; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH/CDC), Morgantown, West Virginia 26505 2: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201 3: Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry (ATSDR/CDC), 1600 Clifton Road NE, F-32, Atlanta, GA 30333 4: School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506; Source Info: 2009, Vol. 109 Issue 1, p50; Subject Term: MOLECULAR dynamics; Subject Term: DENSITY functionals; Subject Term: SURFACE chemistry; Subject Term: QUARTZ; Subject Term: SILICOSIS; Author-Supplied Keyword: density functional theory; Author-Supplied Keyword: molecular dynamics; Author-Supplied Keyword: quartz; Author-Supplied Keyword: silica toxicity; Author-Supplied Keyword: silicosis; Author-Supplied Keyword: surfaces; Number of Pages: 15p; Illustrations: 4 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1002/qua.21726
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fernandez, M. E.
AU - Bartholomew, L. K.
AU - Alterman, T.
T1 - Planning a Multilevel Intervention to Prevent Hearing Loss among Farmworkers and Managers: A Systematic Approach.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2009/01//
VL - 15
IS - 1
M3 - Article
SP - 49
EP - 74
SN - 10747583
AB - The article explores the systematic approach Intervention Mapping (IM) to intervention development for a program to prevent hearing loss among farmworkers and managers. The study aims to approach intervention on noise-induced hearing loss, the second most dominant occupational injury in the U.S. It notes on the use of twelve performance objectives that are being determined and crossed with six relevant determinants to make a highly detailed matrix of change objectives for farmworkers and for their managers. Moreover, the study defined theoretical methods and practical strategies to address multilevel intervention to prevent hearing loss among the subjects.
KW - Industrial safety
KW - Noise-induced deafness
KW - Deafness -- Prevention
KW - Agriculture -- Accidents -- Prevention
KW - Farm life
KW - Occupational mortality
KW - Health planning
KW - Accident prevention
KW - United States
KW - Farmworkers
KW - Health promotion
KW - Hearing loss
KW - Injury prevention
KW - Intervention mapping
KW - Noise
KW - Occupational health
KW - United States.
N1 - Accession Number: 36540836; Fernandez, M. E. 1; Email Address: Maria.E.Fernandez@uth.tmc.edu; Bartholomew, L. K. 1; Alterman, T. 2; Affiliations: 1: Center for Health Promotion and Prevention Research, The University of Texas- Houston School of Public Health, Houston, Texas; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jan2009, Vol. 15 Issue 1, p49; Thesaurus Term: Industrial safety; Subject Term: Noise-induced deafness; Subject Term: Deafness -- Prevention; Subject Term: Agriculture -- Accidents -- Prevention; Subject Term: Farm life; Subject Term: Occupational mortality; Subject Term: Health planning; Subject Term: Accident prevention; Subject: United States; Author-Supplied Keyword: Farmworkers; Author-Supplied Keyword: Health promotion; Author-Supplied Keyword: Hearing loss; Author-Supplied Keyword: Injury prevention; Author-Supplied Keyword: Intervention mapping; Author-Supplied Keyword: Noise; Author-Supplied Keyword: Occupational health; Author-Supplied Keyword: United States.; Number of Pages: 26p; Illustrations: 2 Diagrams; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mujuru, P.
AU - Helmkamp, J. C.
AU - Mutambudzi, M.
AU - Hu, W.
AU - Bell, J. L.
T1 - Evaluating the Impact of an Intervention to Reduce Injuries among Loggers in West Virginia, 1999-2007.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2009/01//
VL - 15
IS - 1
M3 - Article
SP - 75
EP - 88
SN - 10747583
AB - The article focuses on the efficacy of a video-based safety training intervention (VBSTI) to reduce injuries among loggers from 1999-2007 in West Virginia. The study gathered information from WV Workers' Compensation data on assessing the trend in injury rates, medical and damage costs caused by logging injuries. Statistical findings show that there is a significant decrease on head and neck injuries, medical and damage costs, a significant increase on fall, while no changes in struck-by-object accidents. Hence, the study concludes that no defined assessment of the decreasing claims is attributed by the VBSTI.
KW - HEALTH
KW - Industrial safety
KW - Occupational mortality
KW - Safety education
KW - Loggers
KW - Logging -- Accidents
KW - Workers' compensation
KW - Safety signs
KW - Rural development projects -- Evaluation
KW - West Virginia
KW - Logging injuries
KW - Occupational injuries
KW - Safety training programs
N1 - Accession Number: 36540837; Mujuru, P. 1; Email Address: pmujuru@hsc.wvu.edu; Helmkamp, J. C. 2,3; Mutambudzi, M. 4; Hu, W. 5; Bell, J. L. 6; Affiliations: 1: Assistant Professor, West Virginia University Department of Community Medicine, Morgantown, West Virginia; 2: Director, West Virginia University Injury Control Research Center, Morgantown, West Virginia; 3: Research Professor, West Virginia University Department of Community Medicine, Morgantown, West Virginia; 4: Research Assistant, Section of Occupational/Environmental Medicine, Division of Public Health and Population Sciences, University of Connecticut Health Center, Farmington, Connecticut; 5: Research Associate, West Virginia University Department of Community Medicine, Morgantown, West Virginia; 6: Research Epidemiologist, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia; Issue Info: Jan2009, Vol. 15 Issue 1, p75; Thesaurus Term: HEALTH; Thesaurus Term: Industrial safety; Subject Term: Occupational mortality; Subject Term: Safety education; Subject Term: Loggers; Subject Term: Logging -- Accidents; Subject Term: Workers' compensation; Subject Term: Safety signs; Subject Term: Rural development projects -- Evaluation; Subject: West Virginia; Author-Supplied Keyword: Logging injuries; Author-Supplied Keyword: Occupational injuries; Author-Supplied Keyword: Safety training programs; NAICS/Industry Codes: 113312 Contract logging; NAICS/Industry Codes: 113310 Logging; NAICS/Industry Codes: 113311 Logging (except contract); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 524129 Other direct insurance (except life, health and medical) carriers; Number of Pages: 14p; Illustrations: 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Johnson, Rudolph C.
AU - Yingtao Zhou
AU - Statler, Kristen
AU - Thomas, Jerry
AU - Cox, Frederick
AU - Hall, Sherwood
AU - Barr, John R.
T1 - Quantification of Saxitoxin and Neosaxitoxin in Human Urine Utilizing Isotope Dilution Tandem Mass Spectrometry.
JO - Journal of Analytical Toxicology
JF - Journal of Analytical Toxicology
Y1 - 2009/01//Jan/Feb2009
VL - 33
IS - 1
M3 - Article
SP - 8
EP - 14
SN - 01464760
AB - The article presents a study which discusses the quantification of saxitoxin (STX) and neosaxitoxin (NEO) in urine from human which utilizes isotope dilution tandem mass spectroscopy (IDMS). The study used STX and NEO stock solution in which its extracted samples were injected into mass spectrometry (MS) with the use of an Agilent 1100 capillary HPLC. The study also applied a data analysis using the Analyst 1.4.2 instrument software, and relative recovery experiments. The result shows that a new methodology was developed to quantify human urinary concentrations of saxitoxin and neosaxitoxin with the use of IDMS method .
KW - SAXITOXIN
KW - URINALYSIS
KW - MASS spectrometry
KW - ISOTOPES
KW - DILUTION
KW - SCIENTIFIC method
KW - CAPILLARIES
N1 - Accession Number: 37575317; Johnson, Rudolph C. 1 Yingtao Zhou 1 Statler, Kristen 1 Thomas, Jerry 1 Cox, Frederick 2 Hall, Sherwood 3 Barr, John R. 1; Affiliation: 1: Division of Laboratory Sciences, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F44, Atlanta, Georgia 30341 2: Battelle Eastern Science and Technology Center, Aberdeen, Maryland 21001 3: Office of Regulatory Science (HFS-71 6), Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740; Source Info: Jan/Feb2009, Vol. 33 Issue 1, p8; Subject Term: SAXITOXIN; Subject Term: URINALYSIS; Subject Term: MASS spectrometry; Subject Term: ISOTOPES; Subject Term: DILUTION; Subject Term: SCIENTIFIC method; Subject Term: CAPILLARIES; Number of Pages: 7p; Illustrations: 2 Charts, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jonghoon Choi
AU - Qin Zhang
AU - Reipa, Vytas
AU - Nam Sun Wang
AU - Stratmeyer, Melvin E.
AU - Hitchinsc, Victoria M.
AU - Goering, Peter L.
T1 - Comparison of cytotoxic and inflammatory responses of photoluminescent silicon nanoparticles with silicon micron-sized particles in RAW 264.7 macrophages.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2009/01//
VL - 29
IS - 1
M3 - Article
SP - 52
EP - 60
SN - 0260437X
AB - The article evaluates the biological responses of silicon nanoparticles (SNs, 3nm diameter) with silicon microparticles (SMs, ~100-300 nm diameter) in RAW 264.7 macrophages. Standard protocols for evaluating cytotoxicity or cell viability and inflammatory responses for micron-sized particles were used in the study. SNs and SMs were exposed to RAW 264.7 macrophages with and without addition of lipopolysaccharide (LPS). Assayed in the study were cell supernatants for production TNF-a, IL-6 and NO. The results of the study reveal that the comparison of differences in biological responses for nanoparticles compared with microparticles of the same material may help improve study to evaluate biological responses of nanoparticles that may be used in biomedical applications.
KW - RESEARCH
KW - Genetic toxicology
KW - Toxicology
KW - Silicon
KW - Nanoparticles
KW - Macrophages
KW - Antigen presenting cells
KW - Cytokines
KW - Tumor necrosis factor
KW - Interleukin-6
KW - cytokines
KW - cytotoxicity
KW - macrophages
KW - nanoparticles
KW - silicon
KW - tumor necrosis factor-α interleukin-6
N1 - Accession Number: 36260435; Jonghoon Choi 1,2,3; Qin Zhang 3; Reipa, Vytas 2; Nam Sun Wang 1; Email Address: nsw@umd.edu; Stratmeyer, Melvin E. 3; Hitchinsc, Victoria M. 3; Goering, Peter L. 3; Affiliations: 1: Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA; 2: Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA; 3: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA; Issue Info: Jan2009, Vol. 29 Issue 1, p52; Thesaurus Term: RESEARCH; Thesaurus Term: Genetic toxicology; Subject Term: Toxicology; Subject Term: Silicon; Subject Term: Nanoparticles; Subject Term: Macrophages; Subject Term: Antigen presenting cells; Subject Term: Cytokines; Subject Term: Tumor necrosis factor; Subject Term: Interleukin-6; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: cytotoxicity; Author-Supplied Keyword: macrophages; Author-Supplied Keyword: nanoparticles; Author-Supplied Keyword: silicon; Author-Supplied Keyword: tumor necrosis factor-α interleukin-6; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Graphs; Document Type: Article
L3 - 10.1002/jat.1382
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scherr, Daniel
AU - Dalal, Darshan
AU - Cheema, Aamir
AU - Nazarian, Saman
AU - Almasry, Ibrahim
AU - Bilchick, Kenneth
AU - Cheng, Alan
AU - Henrikson, Charles A.
AU - Spragg, David
AU - Marine, Joseph E.
AU - Berger, Ronald D.
AU - Calkins, Hugh
AU - Dong, Jun
T1 - Long- and Short-Term Temporal Stability of Complex Fractionated Atrial Electrograms in Human Left Atrium During Atrial Fibrillation.
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
Y1 - 2009/01//
VL - 20
IS - 1
M3 - Article
SP - 13
EP - 21
PB - Wiley-Blackwell
SN - 10453873
AB - Background: Complex fractionated atrial electrograms (CFAEs) have been reported as targets for catheter ablation of atrial fibrillation (AF). However, the temporal stability of CFAE sites remains poorly defined. Methods and Results: The study consisted of two phases. In the initial phase, two automated software algorithms, namely the interval confidence level (ICL) and the average interpotential interval (AIPI) were assessed for their diagnostic accuracy for automated CFAE detection. The AIPI was found to be superior to the ICL, and an AIPI of ≤100 ms was associated with a sensitivity and specificity of both 92% for detection of CFAEs. In the second phase of the study, 12 patients (2 females, mean age 54 ± 12 years) who underwent catheter ablation for persistent AF were studied to investigate the temporal stability of CFAEs. Two consecutive left atrial (LA) three-dimensional CFAE maps coded with AIPI readings were reconstructed during ongoing AF in each study patient, with a mean time difference of 34.3 ± 8.7 minutes between the two maps. Among a total of 149 CFAE sites and 238 non-CFAE sites on the first CFAE map that were precisely revisited during the repeat mapping process, 135 (90.6%) and 225 (94.5%) remained as CFAE sites and non-CFAE sites, respectively. RF ablation at the selected stable CFAE sites significantly prolonged AF cycle length (181 ± 26 ms to 199 ± 29 ms, P < 0.0001). Conclusion: CFAEs recorded in the LA during AF display high temporal stability in patients with persistent AF. The clinical significance of our findings warrants further investigation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cardiovascular Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATRIAL fibrillation
KW - CATHETER ablation
KW - PULMONARY veins
KW - DIAGNOSIS
KW - CARDIOVASCULAR diseases
KW - ablation
KW - atrial fibrillation
KW - atrium
KW - complex atrial electrogram
KW - mapping
N1 - Accession Number: 35867578; Scherr, Daniel 1,2 Dalal, Darshan 1 Cheema, Aamir 1 Nazarian, Saman 1 Almasry, Ibrahim 1 Bilchick, Kenneth 1 Cheng, Alan 1 Henrikson, Charles A. 1 Spragg, David 1 Marine, Joseph E. 1 Berger, Ronald D. 1 Calkins, Hugh 1 Dong, Jun 1,3; Email Address: jun.dong@fda.hhs.gov; Affiliation: 1: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 2: Division of Cardiology, Department of Medicine, Medical University of Graz, Austria 3: Division of Cardiovascular Devices, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Jan2009, Vol. 20 Issue 1, p13; Subject Term: ATRIAL fibrillation; Subject Term: CATHETER ablation; Subject Term: PULMONARY veins; Subject Term: DIAGNOSIS; Subject Term: CARDIOVASCULAR diseases; Author-Supplied Keyword: ablation; Author-Supplied Keyword: atrial fibrillation; Author-Supplied Keyword: atrium; Author-Supplied Keyword: complex atrial electrogram; Author-Supplied Keyword: mapping; Number of Pages: 9p; Illustrations: 2 Diagrams, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1540-8167.2008.01278.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Jinchun
AU - Schnackenberg, Laura K.
AU - Holland, Ricky D.
AU - Schmitt, Thomas C.
AU - Cantor, Glenn H.
AU - Dragan, Yvonne P.
AU - Beger, Richard D.
T1 - Corrigendum to “Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS” [J. Chromatogr. B 871 (2008) 328]
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/01//
VL - 877
IS - 1/2
M3 - Correction notice
SP - 105
EP - 105
SN - 15700232
N1 - Accession Number: 35769968; Sun, Jinchun 1 Schnackenberg, Laura K. 1 Holland, Ricky D. 1 Schmitt, Thomas C. 1 Cantor, Glenn H. 2 Dragan, Yvonne P. 1 Beger, Richard D. 1; Email Address: Richard.Beger@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States 2: Investigative Toxicology, Pharmacia Corp., Kalamazoo, MI 49001, United States; Source Info: Jan2009, Vol. 877 Issue 1/2, p105; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.jchromb.2008.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105448181
T1 - Contextualization of physical and sexual assault in male prisons: incidents and their aftermath.
AU - Wolff N
AU - Shi J
Y1 - 2009/01//
N1 - Accession Number: 105448181. Language: English. Entry Date: 20090501. Revision Date: 20150818. Publication Type: Journal Article; research; tables/charts. Note: For CE see pages 75-85. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. Grant Information: Office of Justice Programs (grant #OJP-2004-RP-BX-0012) and the National Institute of Mental Health (grant #P20 MH66170). NLM UID: 9503759.
KW - Assault and Battery
KW - Correctional Facilities
KW - Sexual Abuse
KW - Adult
KW - Chi Square Test
KW - Education, Continuing (Credit)
KW - Emotions
KW - Fisher's Exact Test
KW - Funding Source
KW - Male
KW - Middle Age
KW - Wounds and Injuries
KW - Human
SP - 58
EP - 77
JO - Journal of Correctional Health Care
JF - Journal of Correctional Health Care
JA - J CORRECTIONAL HEALTH CARE
VL - 15
IS - 1
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - Physical and sexual assault are part of the prison experience. Approximately 21% of male inmates are physically assaulted during a 6-month period. Sexual assault is estimated at between 2% and 5%. Although prevalence evidence is growing, less is known about circumstances surrounding and resulting from these incidents. This article presents an analysis of approximately 2,200 physical and 200 sexual victimizations reported by a random sample of 6,964 male inmates. Physical injury occurred in 40% of physical assaults and 70% of sexual assaults between inmates and in 50% of assaults perpetrated by staff. Emotional reactions to assaults were experienced by virtually all victims. Context information is vital in the development and implementation of prevention and therapeutic interventions.
SN - 1078-3458
AD - Center for Mental Health Services and Criminal Justice Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, nwolff@ifh.rutgers.edu
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ray, Paresh Chandra
AU - Yu, Hongtao
AU - Fu, Peter P.
T1 - Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2009/01//Jan-Mar2009
VL - 27
IS - 1
M3 - Article
SP - 1
EP - 35
SN - 10590501
AB - Nanotechnology has gained a great deal of public interest because of the needs and applications of nanomaterials in many areas of human endeavors including industry, agriculture, business, medicine, and public health. Environmental exposure to nanomaterials is inevitable as nanomaterials become part of our daily life, and, as a result, nanotoxicity research is gaining attention. This review presents a summary of recent research efforts on fate, behavior, and toxicity of different classes of nanomaterials in the environment. A critical evaluation of challenges and future needs for the safe environmental nanotechnology are discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Nanotechnology -- Environmental aspects
KW - Environmental toxicology
KW - Environmental risk assessment
KW - Public health
KW - Nanostructured materials
KW - Carbon nanotubes
KW - Transmission electron microscopy
KW - Surface plasmon resonance
KW - carbon
KW - environmental impact
KW - gold
KW - metal oxides
KW - Nanomaterials
KW - silver
KW - toxicity
N1 - Accession Number: 36433165; Ray, Paresh Chandra 1; Email Address: paresh.c.ray@jsums.edu; Yu, Hongtao 1; Fu, Peter P. 2; Affiliations: 1: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA; Issue Info: Jan-Mar2009, Vol. 27 Issue 1, p1; Thesaurus Term: Nanotechnology -- Environmental aspects; Thesaurus Term: Environmental toxicology; Thesaurus Term: Environmental risk assessment; Thesaurus Term: Public health; Subject Term: Nanostructured materials; Subject Term: Carbon nanotubes; Subject Term: Transmission electron microscopy; Subject Term: Surface plasmon resonance; Author-Supplied Keyword: carbon; Author-Supplied Keyword: environmental impact; Author-Supplied Keyword: gold; Author-Supplied Keyword: metal oxides; Author-Supplied Keyword: Nanomaterials; Author-Supplied Keyword: silver; Author-Supplied Keyword: toxicity; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 35p; Illustrations: 1 Color Photograph, 2 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1080/10590500802708267
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - SCHLESSER, JOSEPH E.
AU - PARISI, BRIAN
T1 - Inactivation of Yersinia pseudotuberculosis 197 and Francisella tularensis LVS in Beverages by High Pressure Processing.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/01//
VL - 72
IS - 1
M3 - Article
SP - 165
EP - 168
SN - 0362028X
AB - In 2003, the U.S. Department of Health and Human Services announced a new research program to develop technologies and strategies to prevent and minimize potential food safety and security threats. The threat of terrorist attacks against the nation's food supplies has created the need to study microorganisms not typically associated with foodborne illness. High-pressure processing has been proposed as a treatment to reduce Yersinia pestis and Francisella tularensis LVS levels in beverages. The objectives of this work were to determine the pressure resistance of Y. pseudotuberculosis 197 (surrogate for Y. pestis) and F. tularensis LVS (vaccine strain). For each bacterium, samples of ultrahigh-temperature pasteurized skim milk and pasteurized reduced-acid orange juice (pH ca. 4.2) were inoculated at a minimum level of 5 log CFU/ml. Ten-milliliter samples of the inoculated product were vacuum sealed in polyester pouches and subjected to pressures of 300 and 500 MPa for holding times ranging from 30 s to 6 min. One set of trials was performed at an initial temperature of 10°C and another at 25°C. Processed samples were immediately plated and enumerated. A pressure treatment of 300 MPa at 25°C for less than 6 min was not sufficient to achieve a 5-log reduction of Y. pseudotuberculosis 197 or F. tularensis LVS in milk. However, a pressure treatment of 500 MPa was effective at hold times as low as 30 s. Overall, F. tularensis LVS demonstrated less pressure resistance than Y. pseudotuberculosis 197. Based on these findings, a high-pressure process design to inactive 5 log CFU of Y pseudotuberculosis 197 per ml and F. tularensis LVS in orange juice or milk should be set at or above 500 MPa with a hold time of 2 min or greater. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Yersinia pseudotuberculosis
KW - Francisella tularensis
KW - Beverages
KW - High pressure (Science)
KW - Polyesters
N1 - Accession Number: 36209892; SCHLESSER, JOSEPH E. 1; Email Address: joseph.schlesser@fda.hhs.gov; PARISI, BRIAN 2; Affiliations: 1: Food and Drug Administration, National Center for Food Safety and Technology, Moffett Campus, Summit-Argo, Illinois 60501, USA; 2: Illinois Institute of Technology, National Center for Food Safety and Technology, Moffett Campus, Summit-Argo, Illinois 60501, USA; Issue Info: Jan2009, Vol. 72 Issue 1, p165; Subject Term: Yersinia pseudotuberculosis; Subject Term: Francisella tularensis; Subject Term: Beverages; Subject Term: High pressure (Science); Subject Term: Polyesters; NAICS/Industry Codes: 313110 Fiber, Yarn, and Thread Mills; Number of Pages: 4p; Illustrations: 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - MELDRUM, R. J.
AU - MANNION, P. T.
AU - GARSIDE, J.
T1 - Microbiological Quality of Ready-to-Eat Food Served in Schools in Wales, United Kingdom.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/01//
VL - 72
IS - 1
M3 - Article
SP - 197
EP - 201
SN - 0362028X
AB - A survey of the general microbiological quality of ready-to-eat food served in schools was undertaken across Wales, United Kingdom. Of the 2,351 samples taken, four were identified as containing unsatisfactory counts of Escherichia coli, four contained unsatisfactory counts of Staphylococcus aureus, and one contained an unacceptable count of Bacillus cereus when compared with guidelines for the microbiological quality of ready-to-eat food published by the United Kingdom Public Health Laboratory Service in 2000. No samples contained detectable levels of Salmonella, Listeria species, or Clostridium perfringens. When compared with data on the general microbiological quality of food available in Wales, the food sampled from schools was of relatively better microbiological quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Microbiology
KW - Food contamination
KW - Food -- Analysis
KW - Food -- Quality
KW - School children -- Food
KW - Wales
N1 - Accession Number: 36209900; MELDRUM, R. J. 1; Email Address: richard.meldrum@nphs.wales.nhs.uk; MANNION, P. T. 2; GARSIDE, J. 3; Affiliations: 1: Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK; 2: National Public Health Service Microbiology Rhyl, Glan Clwyd Hospital, Rhyl LL18 5UJ, UK; 3: Blaenau Gwent County Borough Council, Civic Centre, Ebbw Vale NP23 6XB, UK; Issue Info: Jan2009, Vol. 72 Issue 1, p197; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Food contamination; Subject Term: Food -- Analysis; Subject Term: Food -- Quality; Subject Term: School children -- Food; Subject: Wales; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Jiang, H. Joanna
AU - Lockee, Carlin
AU - Bass, Karma
AU - Fraser, Irene
T1 - Board Oversight of Quality: Any Differences in Process of Care and Mortality?
JO - Journal of Healthcare Management
JF - Journal of Healthcare Management
Y1 - 2009/01//Jan/Feb2009
VL - 54
IS - 1
M3 - Article
SP - 15
EP - 30
PB - American College of Healthcare Executives
SN - 10969012
AB - In response to legal and accreditation mandates as well as pressures from purchasers and consumers for quality improvement, hospital governing boards seek to improve their oversight of quality of care by adopting various practices. Based on a previous survey of hospital presidents/chief executive officers, this study examines differences in hospital quality performance associated with the adoption of particular practices in board oversight of quality. Quality was measured by performance in process of care and risk-adjusted mortality, using the Hospital Compare data from the Centers for Medicare & Medicaid Services and the Healthcare Cost and Utilization Project inpatient databases of the Agency for Healthcare Research and Quality. Board practices found to be associated with better performance in both process of care and mortality include (1) having a board quality committee; (2) establishing strategic goals for quality improvement; (3) being involved in setting the quality agenda for the hospital; (4) including a specific item on quality in board meetings; (5) using a dashboard with national benchmarks that includes indicators for clinical quality, patient safety, and patient satisfaction; and (6) linking senior executives' performance evaluation to quality and patient safety indicators. Involvement of physician leadership in the board quality committee further enhanced the hospital's quality performance. Taken together, these findings seem to support the will-execution-constancy of purpose framework on improving the effectiveness of hospital boards in overseeing quality. Future study should examine how specific board practices influence the culture and operations of the hospital that lead to better quality of care. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Healthcare Management is the property of American College of Healthcare Executives and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITAL administration
KW - MEDICAL care -- Quality control
KW - PATIENT satisfaction
KW - CHIEF executive officers
KW - PHYSICIANS
KW - HOSPITAL trustees
KW - PATIENTS -- Safety measures
N1 - Accession Number: 36822307; Jiang, H. Joanna 1; Email Address: oanna.jiang@ahrq.hhs.gov Lockee, Carlin 2 Bass, Karma 3 Fraser, Irene; Affiliation: 1: Senior Social Scientist, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland. 2: Governance Institute, San Diego. 3: President and CEO, Alliance Healthcare Foundation, Governance Institute, San Diego.; Source Info: Jan/Feb2009, Vol. 54 Issue 1, p15; Subject Term: HOSPITAL administration; Subject Term: MEDICAL care -- Quality control; Subject Term: PATIENT satisfaction; Subject Term: CHIEF executive officers; Subject Term: PHYSICIANS; Subject Term: HOSPITAL trustees; Subject Term: PATIENTS -- Safety measures; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 16p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105641314
T1 - Board oversight of quality: any differences in process of care and mortality?...including commentary by Norwood EP
AU - Jiang HJ
AU - Lockee C
AU - Bass K
AU - Fraser I
Y1 - 2009/01//Jan/Feb2009
N1 - Accession Number: 105641314. Language: English. Entry Date: 20090327. Revision Date: 20150711. Publication Type: Journal Article; commentary; research; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9803529.
KW - Governing Board
KW - Hospitals -- Evaluation
KW - Mortality -- Trends
KW - Quality of Health Care -- Evaluation
KW - Chi Square Test
KW - Clinical Indicators
KW - Descriptive Statistics
KW - P-Value
KW - Survey Research
KW - T-Tests
KW - Treatment Outcomes -- Evaluation
KW - Human
SP - 15
EP - 30
JO - Journal of Healthcare Management
JF - Journal of Healthcare Management
JA - J HEALTHC MANAGE
VL - 54
IS - 1
CY - Chicago, Illinois
PB - American College of Healthcare Executives
SN - 1096-9012
AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland; joanna.jiang@ahrq.hhs.gov
U2 - PMID: 19227851.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Selden, Thomas M.
T1 - The Impact of Increased Tax Subsidies on the Insurance Coverage of Self-Employed Families.
JO - Journal of Human Resources
JF - Journal of Human Resources
Y1 - 2009///Winter2009
VL - 44
IS - 1
M3 - Article
SP - 115
EP - 139
PB - University of Wisconsin Press
SN - 0022166X
AB - The share of health insurance premiums that self-employed workers can deduct when computing federal income taxes rose from 30 percent in 1996 to 100 percent in 2003. Data from the 1996-2004 Medical Expenditure Panel Survey are used to show that the increased tax subsidy was associated with substantial increases in private coverage among self-employed workers and their spouses. Estimated effects on public coverage and the coverage of children were smaller in magnitude and less precisely estimated. Simulation results show that much of the post-1996 subsidy increase represented an inframarginal transfer to persons who would have had held private insurance anyway. Nevertheless, increased subsidization expanded private coverage by 1.1 to 1.7 million persons, at a cost per newly insured person less than $2,300 in all simulations---a cost below that found in simulations of more broadly based subsidies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Human Resources is the property of University of Wisconsin Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAX expenditures
KW - SELF-employed
KW - HEALTH insurance
KW - INSURANCE premiums
KW - INCOME tax
KW - SIMULATION methods & models
KW - SELF-employment
KW - INSURANCE -- Rates
KW - INSURANCE administration services
KW - INSURANCE policies
KW - EMPLOYER-sponsored health insurance
KW - MEDICARE
N1 - Accession Number: 36429702; Selden, Thomas M. 1; Email Address: tselden@ahrq.gov; Affiliations: 1: Economist, Agency for Healthcare Research and Quality; Issue Info: Winter2009, Vol. 44 Issue 1, p115; Thesaurus Term: TAX expenditures; Thesaurus Term: SELF-employed; Thesaurus Term: HEALTH insurance; Thesaurus Term: INSURANCE premiums; Thesaurus Term: INCOME tax; Thesaurus Term: SIMULATION methods & models; Thesaurus Term: SELF-employment; Thesaurus Term: INSURANCE -- Rates; Thesaurus Term: INSURANCE administration services; Thesaurus Term: INSURANCE policies; Thesaurus Term: EMPLOYER-sponsored health insurance; Thesaurus Term: MEDICARE; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 524299 All other insurance related activities; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; Number of Pages: 25p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Dubaniewicz, Thomas H.
T1 - From Scotia to Brookwood, fatal US underground coal mine explosions ignited in intake air courses
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2009/01//
VL - 22
IS - 1
M3 - Article
SP - 52
EP - 58
SN - 09504230
AB - Abstract: The National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, conducted a study of past mine explosions to identify the ignition locations and ignition sources responsible for the most severe explosion events resulting in death. Since the Scotia disaster of 1976, many fatalities from underground coal mine explosions have been linked to nonpermissible electrical equipment ignition sources located in intake air courses. With few exceptions, explosion protected equipment is generally not required in intake air courses of gassy underground coal mines in the US. Cigarette lighters were another prevalent ignition source for fatal explosions ignited in intake air courses. Several mine rescue/recovery teams have encountered electrical ignition hazards. The study provides evidence that intake air courses of gassy underground coal mines fit the description of certain Hazardous (classified) locations described in the US National Electrical Code®. Class I Division 2 or Zone 2 explosion protection techniques may be used to design intake air equipment so that it does not present an ignition source under normal operation, before mine power is shut down in emergency situations. Nonpermissible circuits in intake air courses that are likely to remain energized during emergencies, e.g. battery powered equipment, should be protected by more stringent Class I Division 1, Zone 1, or Zone 0 techniques, to protect rescue/recovery personnel. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - INDUSTRIAL safety
KW - MINE explosions
KW - Class I hazardous location
KW - Coal mines
KW - Explosions
KW - Mining
KW - Traumatic injuries
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 35926191; Dubaniewicz, Thomas H. 1; Email Address: tcd5@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh, PA 15236, USA; Issue Info: Jan2009, Vol. 22 Issue 1, p52; Thesaurus Term: COAL mines & mining; Thesaurus Term: INDUSTRIAL safety; Subject Term: MINE explosions; Author-Supplied Keyword: Class I hazardous location; Author-Supplied Keyword: Coal mines; Author-Supplied Keyword: Explosions; Author-Supplied Keyword: Mining; Author-Supplied Keyword: Traumatic injuries ; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jlp.2008.08.010
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - He, Xiaoqing
AU - Kan, Hong
AU - Cai, Lu
AU - Ma, Qiang
T1 - Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
JO - Journal of Molecular & Cellular Cardiology
JF - Journal of Molecular & Cellular Cardiology
Y1 - 2009/01//
VL - 46
IS - 1
M3 - Article
SP - 47
EP - 58
SN - 00222828
AB - Abstract: Exposure to high levels of glucose induces the production of reactive oxygen species (ROS) in cardiomyocytes that may contribute to the development of cardiomyopathy in diabetes. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative stress. The role of Nrf2 in defense against high glucose-induced oxidative damage in cardiomyocytes was investigated. Glucose at high concentrations induced ROS production in both primary neonatal and adult cardiomyocytes from the Nrf2 wild type (WT) mouse heart, whereas, in Nrf2 knockout (KO) cells, ROS was significantly higher under basal conditions and high glucose markedly further increased ROS production in concentration and time-dependent manners. Concomitantly, high glucose induced significantly higher levels of apoptosis at lower concentrations and in shorter time in Nrf2 KO cells than in WT cells. Primary adult cardiomyocytes from control and diabetic mice also showed dependence on Nrf2 function for isoproterenol-stimulated contraction. Additionally, cardiomyocytes from Nrf2 KO mice exhibited increased sensitivity to 3-nitropropionic acid, an inhibitor of mitochondrial respiratory complex II, for both ROS production and apoptosis compared with Nrf2 WT cells, further emphasizing the role of Nrf2 in ROS defense in the cells. Mechanistically, Nrf2 was shown to mediate the basal expression and induction of ARE-controlled cytoprotective genes, Nqo1 and Ho1, at both mRNA and protein levels in cardiomyocytes, as both the basal and inducible expressions of the genes were lost in Nrf2 KO cells or largely reduced by Nrf2 SiRNA. The findings, for the first time, established Nrf2 as a critical regulator of defense against ROS in normal and diabetic hearts. [Copyright &y& Elsevier]
AB - Copyright of Journal of Molecular & Cellular Cardiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSCRIPTION factors
KW - HEART cells
KW - GLUCOSE
KW - CARDIOMYOPATHIES
KW - OXIDATIVE stress
KW - STREPTOZOTOCIN
KW - ANTIOXIDANTS
KW - 3-nitropropionic acid ( 3NP )
KW - 4′,6-diamidino-2-phenylindole ( DAPI )
KW - adult mouse ventricular myocyte ( AMVM )
KW - Antioxidant
KW - Diabetic cardiomyopathy
KW - dihydroethium ( DHE )
KW - Glucose
KW - heme oxygenase 1 ( HO1 )
KW - NAD(P)H:quinone oxidoreductase 1 ( NQO1 )
KW - Nrf2
KW - Nuclear factor erythroid 2-related factor 2 ( Nrf2 )
KW - Oxidative stress
KW - Reactive oxygen species
KW - streptozotocin ( STZ )
N1 - Accession Number: 35710725; He, Xiaoqing 1 Kan, Hong 2 Cai, Lu 3; Email Address: 10cai001@louisville.edu Ma, Qiang 1; Email Address: qam1@cdc.gov; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA 2: Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV, USA 3: Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA; Source Info: Jan2009, Vol. 46 Issue 1, p47; Subject Term: TRANSCRIPTION factors; Subject Term: HEART cells; Subject Term: GLUCOSE; Subject Term: CARDIOMYOPATHIES; Subject Term: OXIDATIVE stress; Subject Term: STREPTOZOTOCIN; Subject Term: ANTIOXIDANTS; Author-Supplied Keyword: 3-nitropropionic acid ( 3NP ); Author-Supplied Keyword: 4′,6-diamidino-2-phenylindole ( DAPI ); Author-Supplied Keyword: adult mouse ventricular myocyte ( AMVM ); Author-Supplied Keyword: Antioxidant; Author-Supplied Keyword: Diabetic cardiomyopathy; Author-Supplied Keyword: dihydroethium ( DHE ); Author-Supplied Keyword: Glucose; Author-Supplied Keyword: heme oxygenase 1 ( HO1 ); Author-Supplied Keyword: NAD(P)H:quinone oxidoreductase 1 ( NQO1 ); Author-Supplied Keyword: Nrf2; Author-Supplied Keyword: Nuclear factor erythroid 2-related factor 2 ( Nrf2 ); Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: streptozotocin ( STZ ); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.yjmcc.2008.10.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jinshun Zhao
AU - Bowman, Linda
AU - Xingdong Zhang
AU - Xianglin Shi
AU - Binghua Jiang
AU - Castranova, Vincent
AU - Min Ding
T1 - Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway.
JO - Journal of Nanobiotechnology
JF - Journal of Nanobiotechnology
Y1 - 2009/01//
VL - 7
M3 - Article
SP - 1
EP - 13
SN - 14773155
AB - Background: Carcinogenicity of nickel compounds has been well documented. However, the carcinogenic effect of metallic nickel is still unclear. The present study investigates metallic nickel nano- and fine particle-induced apoptosis and the signal pathways involved in this process in JB6 cells. The data obtained from this study will be of benefit for elucidating the pathological and carcinogenic potential of metallic nickel particles. Results: Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, we found that metallic nickel nanoparticles exhibited higher cytotoxicity than fine particles. Both metallic nickel nano- and fine particles induced JB6 cell apoptosis. Metallic nickel nanoparticles produced higher apoptotic induction than fine particles. Western-blot analysis showed an activation of proapoptotic factors including Fas (CD95), Fas-associated protein with death domain (FADD), caspase-8, death receptor 3 (DR3) and BID in apoptotic cells induced by metallic nickel particles. Immunoprecipitation (IP) western blot analysis demonstrated the formation of the Fas-related death-inducing signaling complex (DISC) in the apoptotic process. Furthermore, lamin A and beta-actin were cleaved. Moreover, we found that apoptosis-inducing factor (AIF) was up-regulated and released from mitochondria to cytoplasm. Interestingly, although an up-regulation of cytochrome c was detected in the mitochondria of metallic nickel particle-treated cells, no cytochrome c release from mitochondria to cytoplasm was found. In addition, activation of antiapoptotic factors including phospho-Akt (protein kinase B) and Bcl-2 was detected. Further studies demonstrated that metallic nickel particles caused no significant changes in the mitochondrial membrane permeability after 24 h treatment. Conclusion: In this study, metallic nickel nanoparticles caused higher cytotoxicity and apoptotic induction than fine particles in JB6 cells. Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase- 8/AIF mediated cytochrome c-independent pathway. Lamin A and beta-actin are involved in the process of apoptosis. Activation of Akt and Bcl-2 may play an important role in preventing cytochrome c release from mitochondria to the cytoplasm and may also be important in the carcinogenicity of metallic nickel particles. In addition, the results may be useful as an important reference when comparing the toxicities of different nickel compounds. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NICKEL
KW - CYTOCHROMES
KW - APOPTOSIS
KW - MITOCHONDRIA
KW - TOXICITY testing
N1 - Accession Number: 41990702; Jinshun Zhao 1; Email Address: fyq9@cdc.gov Bowman, Linda 1; Email Address: llb2@cdc.gov Xingdong Zhang 1; Email Address: xaz5@cdc.gov Xianglin Shi 2; Email Address: xshi5@email.uky.edu Binghua Jiang 3; Email Address: bhjiang@hsc.wvu.edu Castranova, Vincent 1; Email Address: vic1@cdc.gov Min Ding 1; Email Address: mid5@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA 2: Graduate Center for Toxicology, College of Medicine, the University of Kentucky, Lexington, KY, 40515, USA 3: Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV, 26505, USA; Source Info: 2009, Vol. 7, p1; Subject Term: NICKEL; Subject Term: CYTOCHROMES; Subject Term: APOPTOSIS; Subject Term: MITOCHONDRIA; Subject Term: TOXICITY testing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 13p; Illustrations: 2 Color Photographs, 2 Black and White Photographs, 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1186/1477-3155-7-2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vincent Castranova
T1 - The Nanotoxicology Research Program in NIOSH.
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
Y1 - 2009/01//
VL - 11
IS - 1
M3 - Article
SP - 5
EP - 13
SN - 13880764
AB - Abstract The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanoparticle Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH technology
KW - TECHNOLOGY
KW - BIOTECHNOLOGY
KW - INFORMATION technology
KW - HIGH technology industries
N1 - Accession Number: 35912231; Vincent Castranova 1; Affiliation: 1: National Institute for Occupational Safety and Health Health Effects Laboratory Division Morgantown WV 26505 USA; Source Info: Jan2009, Vol. 11 Issue 1, p5; Subject Term: HIGH technology; Subject Term: TECHNOLOGY; Subject Term: BIOTECHNOLOGY; Subject Term: INFORMATION technology; Subject Term: HIGH technology industries; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Toshihiko Myojo
AU - Takako Oyabu
AU - Kenichiro Nishi
AU - Chikara Kadoya
AU - Isamu Tanaka
AU - Mariko Ono-Ogasawara
AU - Hirokazu Sakae
AU - Tadashi Shirai
T1 - Aerosol generation and measurement of multi-wall carbon nanotubes.
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
Y1 - 2009/01//
VL - 11
IS - 1
M3 - Article
SP - 91
EP - 99
SN - 13880764
AB - Abstract Mass production of some kinds of carbon nanotubes (CNT) is now imminent, but little is known about the risk associated with their exposure. It is important to assess the propensity of the CNT to release particles into air for its risk assessment. In this study, we conducted aerosolization of a multi-walled CNT (MWCNT) to assess several aerosol measuring instruments. A Palas RBG-1000 aerosol generator applied mechanical stress to the MWCNT by a rotating brush at feed rates ranging from 2 to 20 mm/h, which the MWCNT was fed to a two-component fluidized bed. The fluidized bed aerosol generator was used to disperse the MWCNT aerosol once more. We monitored the generated MWCNT aerosol concentrations based on number, area, and mass using a condensation particle counter and nanoparticle surface area monitor. Also we quantified carbon mass in MWCNT aerosol samples by a carbon monitor. The shape of aerosolized MWCNT fibers was observed by a scanning electron microscope (SEM). The MWCNT was well dispersed by our system. We found isolated MWCNT fibers in the aerosols by SEM and the count median lengths of MWCNT fibers were 4–6 μm. The MWCNT was quantified by the carbon monitor with a modified condition based on the NIOSH analytical manual. The MWCNT aerosol concentration (EC mass base) was 4 mg/m3 at 2 mm/h in this study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanoparticle Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTRON microscopes
KW - MICROSCOPES
KW - HIGH-voltage electron microscopes
KW - SCANNING electron microscopes
KW - TRANSMISSION electron microscopes
N1 - Accession Number: 35912233; Toshihiko Myojo 1 Takako Oyabu 1 Kenichiro Nishi 1 Chikara Kadoya 1 Isamu Tanaka 1 Mariko Ono-Ogasawara 2 Hirokazu Sakae 3 Tadashi Shirai 3; Affiliation: 1: University of Occupational and Environmental Health Institute of Industrial Ecological Sciences Iseigaoka 1-1 Kitakyushu 807-8555 Japan 2: National Institute of Occupational Safety and Health Kawasaki Japan 3: Tokyo Dylec Co. Tokyo Japan; Source Info: Jan2009, Vol. 11 Issue 1, p91; Subject Term: ELECTRON microscopes; Subject Term: MICROSCOPES; Subject Term: HIGH-voltage electron microscopes; Subject Term: SCANNING electron microscopes; Subject Term: TRANSMISSION electron microscopes; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; NAICS/Industry Codes: 333314 Optical Instrument and Lens Manufacturing; NAICS/Industry Codes: 333310 Commercial and service industry machinery manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kihong Park
AU - Jae-Seok Kim
AU - Arthur Miller
T1 - A study on effects of size and structure on hygroscopicity of nanoparticles using a tandem differential mobility analyzer and TEM.
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
Y1 - 2009/01//
VL - 11
IS - 1
M3 - Article
SP - 175
EP - 183
SN - 13880764
AB - Abstract A hygroscopicity tandem differential mobility analyzer (HTDMA) technique is used to determine size-effect of nanoparticles (NaCl, (NH4)2SO4, KCl, NH4NO3, MgCl2, CaCl2) on their hygroscopic properties (deliquescence relative humidity (DRH) and hygroscopic growth factor (GF)). The HTDMA system uses a combination of two nano DMAs and two regular DMAs to measure particle size change in a wide dynamic particle size range. Particles are subsequently analyzed with a transmission electron microscopy to investigate the potential effect of particle structure or morphology on the hygroscopic properties. We found that structural properties of NaCl and (NH4)2SO4 particles also play an important role in determination of the DRH and GF and are more pronounced at smaller diameters. Data show that the DRH of NaCl nanoparticles increased from ~75% up to ~83% RH at 8 nm and that their GF decreased with decreasing size. The extent to which the GF of NaCl nanoparticles decreased with decreasing size was greater than theoretically predicted with the Kelvin correction. The GF of furnace-generated NaCl nanoparticles that have pores and aggregate shape was found to be smaller than that of atomizer-generated particles that are close to perfectly cubic. For the case of atomizer-generated (NH4)2SO4 nanoparticles, we observed no significant size-effect on their DRH, and the measured GF agreed well with predicted values using the Kelvin correction. For furnace-generated (NH4)2SO4 nanoparticles, a gradual growth at moderate RH without noticeable deliquescence behavior occurred. Their TEM images showed that contrary to atomizer-generated (NH4)2SO4 nanoparticles the furnace-generated (NH4)2SO4 nanoparticles are not perfectly spherical and are often aggregates having pores and holes, which may favor holding residual water even in the dried condition. For atomizer-generated KCl, MgCl2, and CaCl2 nanoparticles, we observed no significant size-effects on their DRH and GF for the mobility size as small as 20 nm. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nanoparticle Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - KILNS
KW - BRICKMAKING
KW - CERAMICS
KW - FURNACES
KW - POTTERY craft
N1 - Accession Number: 35912229; Kihong Park 1 Jae-Seok Kim 1 Arthur Miller 2; Affiliation: 1: Gwangju Institute of Science and Technology (GIST) Research Center for Biomolecular Nanotechnology, Department of Environmental Science and Engineering 261 Cheomdan-gwagiro (Oryong-dong) Buk-gu Gwangju 500-712 Republic of Korea 2: National Institute for Occupational Safety and Health/Spokane Research Lab Spokane WA 99207 USA; Source Info: Jan2009, Vol. 11 Issue 1, p175; Subject Term: NANOPARTICLES; Subject Term: KILNS; Subject Term: BRICKMAKING; Subject Term: CERAMICS; Subject Term: FURNACES; Subject Term: POTTERY craft; NAICS/Industry Codes: 327110 Pottery, Ceramics, and Plumbing Fixture Manufacturing; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 236210 Industrial Building Construction; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 333414 Heating Equipment (except Warm Air Furnaces) Manufacturing; NAICS/Industry Codes: 423720 Plumbing and Heating Equipment and Supplies (Hydronics) Merchant Wholesalers; NAICS/Industry Codes: 416120 Plumbing, heating and air-conditioning equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333416 Heating equipment and commercial refrigeration equipment manufacturing; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 327120 Clay Building Material and Refractories Manufacturing; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105606627
T1 - AHRQ commentary. Nurses' role in patient safety.
AU - Hughes RG
AU - Clancy CM
Y1 - 2009/01//Jan-Mar2009
N1 - Accession Number: 105606627. Language: English. Entry Date: 20090213. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 9200672.
KW - Nursing Role
KW - Patient Safety
KW - Leadership
KW - Organizational Culture
KW - Quality Improvement
KW - Quality of Health Care
SP - 1
EP - 4
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 24
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850, USA; Ronda.Hughes@ahrq.hhs.gov
U2 - PMID: 19092471.
DO - 10.1097/NCQ.0b013e31818f55c7
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DB - rzh
ER -
TY - JOUR
AU - Coffey, Christopher C.
AU - Pearce, Terri A.
AU - Lawrence, Robert B.
AU - Hudnall, Judith B.
AU - Slaven, James E.
AU - Martin, Stephen B.
T1 - Measurement Capability of Field Portable Organic Vapor Monitoring Instruments Under Different Experimental Conditions.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/01//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 8
PB - Taylor & Francis Ltd
SN - 15459624
AB - The performance of field portable direct-reading organic vapor monitors (DROVMs) was evaluated under a variety of experimental conditions. Four of the DROVMs had photoionization detectors (ppbRAE, IAQRAE, MultiRAE, and Century Toxic Vapor Analyzer), one had a flame ionization detector (Century Toxic Vapor Analyzer), and one was a single-beam infrared spectrophotometer (SapphIRe). Four of each DROVM (two Century Toxic Vapor Analyzers and SapphIRes) were tested. The DROVMs were evaluated at three temperatures (4°C, 21°C, and 38°C), three relative humidities (30%, 60%, and 90%), and two hexane concentrations (5 ppm and 100 ppm). These conditions were selected to provide a range within the operational parameters of all the instruments. At least four replicate trials were performed across the 18 experimental conditions (3 temperatures × 3 relative humidities × 2 concentrations). To evaluate performance, the 4-hr time-weighted average readings from the DROVMs in a given trial were compared with the average of two charcoal tube concentrations using pairwise comparison. The pairwise comparison criterion was ±25% measurement agreement between each individual DROVM and the DROVMs as a group and the average charcoal tube concentration. The ppbRAE group performed the best with 40% of all readings meeting the comparison criterion followed by the SapphIRe group at 39%. Among individual DROVMs, the best performer was a SapphIRe, with 57% of its readings meeting the criterion. The data was further analyzed by temperature, humidity, and concentration. The results indicated the performance of some DROVMs may be affected by temperature, humidity, and/or concentration. The ppbRAE group performed best at 21°C with the percentage of readings meeting the criterion increasing to 63%. At the 5 ppm concentration, 44% of the ppbRAE group readings met the criterion, while at 100 ppm, only 35% did. The results indicate that monitors can be used as survey tools. Based on the data, the inconsistent performance of these DROVMs may not allow them to be used for determining compliance with occupational exposure limits. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vapors
KW - Humidity
KW - Personnel management
KW - Metal organic chemical vapor deposition
KW - Photoionization of gases
KW - Gas detectors
KW - Ionization (Atomic physics)
KW - direct-reading organic vapor monitors
KW - gases
KW - performance
N1 - Accession Number: 75127849; Coffey, Christopher C. 1; Pearce, Terri A. 1; Lawrence, Robert B. 1; Hudnall, Judith B. 1; Slaven, James E. 1; Martin, Stephen B. 1; Affiliations: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Jan2009, Vol. 6 Issue 1, p1; Thesaurus Term: Vapors; Thesaurus Term: Humidity; Subject Term: Personnel management; Subject Term: Metal organic chemical vapor deposition; Subject Term: Photoionization of gases; Subject Term: Gas detectors; Subject Term: Ionization (Atomic physics); Author-Supplied Keyword: direct-reading organic vapor monitors; Author-Supplied Keyword: gases; Author-Supplied Keyword: performance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Document Type: Article
L3 - 10.1080/15459620802514728
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DB - eih
ER -
TY - JOUR
AU - Heitbrink, William A.
AU - Evans, Douglas E.
AU - Ku, Bon Ki
AU - Maynard, Andrew D.
AU - Slavin, Thomas J.
AU - Peters, Thomas M.
T1 - Relationships Among Particle Number, Surface Area, and Respirable Mass Concentrations in Automotive Engine Manufacturing.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/01//
VL - 6
IS - 1
M3 - Article
SP - 19
EP - 31
PB - Taylor & Francis Ltd
SN - 15459624
AB - This study investigated the relationships between particle number, surface area, and respirable mass concentration measured simultaneously in a foundry and an automotive engine machining and assembly center. Aerosol concentrations were measured throughout each plant with a condensation particle counter for number concentration, a diffusion charger for active surface area concentration, and an optical particle counter for respirable mass concentration. At selected locations, particle size distributions were characterized with the optical particle counter and an electrical low pressure impactor. Statistical analyses showed that active surface area concentration was correlated with ultrafine particle number concentration and weakly correlated with respirable mass concentration. Correlation between number and active surface area concentration was stronger during winter (R2 = 0.6 for both plants) than in the summer (R2 = 0.38 and 0.36 for the foundry and engine plant respectively). The stronger correlation in winter was attributed to use of direct-fire gas fired heaters that produced substantial numbers of ultrafine particles with a modal diameter between 0.007 and 0.023 μ m. These correlations support findings obtained through theoretical analysis. Such analysis predicts that active surface area increasingly underestimates geometric surface area with increasing particle size, particularly for particles larger than 100 nm. Thus, a stronger correlation between particle number concentration and active surface area concentration is expected in the presence of high concentrations of ultrafine particles. In general, active surface area concentration may be a concentration metric that is distinct from particle number concentration and respirable mass concentration. For future health effects or toxicological studies involving nano-materials or ultrafine aerosols, this finding needs to be considered, as exposure metrics may influence data interpretation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Automotive engineering
KW - Aerosols (Sprays)
KW - Diffusion
KW - Surface area
KW - Automobile engines -- Manufacture
KW - Machining
KW - active surface area concentration
KW - comparison between exposure metrics
KW - respirable mass concentration
KW - ultrafine number concentration
N1 - Accession Number: 75127847; Heitbrink, William A. 1; Evans, Douglas E. 2; Ku, Bon Ki 2; Maynard, Andrew D. 3; Slavin, Thomas J. 4; Peters, Thomas M. 1; Affiliations: 1: Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Woodrow Wilson International Center for Scholars, Washington, D.C.; 4: International Truck and Engine Corporation, Warrenville, Illinois; Issue Info: Jan2009, Vol. 6 Issue 1, p19; Thesaurus Term: Automotive engineering; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Diffusion; Subject Term: Surface area; Subject Term: Automobile engines -- Manufacture; Subject Term: Machining; Author-Supplied Keyword: active surface area concentration; Author-Supplied Keyword: comparison between exposure metrics; Author-Supplied Keyword: respirable mass concentration; Author-Supplied Keyword: ultrafine number concentration; NAICS/Industry Codes: 811198 All Other Automotive Repair and Maintenance; NAICS/Industry Codes: 541420 Industrial Design Services; NAICS/Industry Codes: 336111 Automobile Manufacturing; NAICS/Industry Codes: 336211 Motor Vehicle Body Manufacturing; Number of Pages: 13p; Document Type: Article
L3 - 10.1080/15459620802530096
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DB - eih
ER -
TY - JOUR
ID - 105566110
T1 - Measurement capability of field portable organic vapor monitoring instruments under different experimental conditions.
AU - Coffey CC
AU - Pearce TA
AU - Lawrence RB
AU - Hudnall JB
AU - Slaven JE
AU - Martin SB Jr.
Y1 - 2009/01//
N1 - Accession Number: 105566110. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air Pollutants -- Analysis
KW - Environmental Monitoring -- Equipment and Supplies
KW - Alkanes -- Analysis
KW - Calibration
KW - Charcoal
KW - Education, Continuing (Credit)
KW - Evaluation Research
KW - Humidity
KW - Temperature
KW - Human
SP - 1
EP - 8
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 1
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The performance of field portable direct-reading organic vapor monitors (DROVMs) was evaluated under a variety of experimental conditions. Four of the DROVMs had photoionization detectors (ppbRAE, IAQRAE, MultiRAE, and Century Toxic Vapor Analyzer), one had a flame ionization detector (Century Toxic Vapor Analyzer), and one was a single-beam infrared spectrophotometer (SapphIRe). Four of each DROVM (two Century Toxic Vapor Analyzers and SapphIRes) were tested. The DROVMs were evaluated at three temperatures (4 degrees C, 21 degrees C, and 38 degrees C), three relative humidities (30%, 60%, and 90%), and two hexane concentrations (5 ppm and 100 ppm). These conditions were selected to provide a range within the operational parameters of all the instruments. At least four replicate trials were performed across the 18 experimental conditions (3 temperatures x 3 relative humidities x 2 concentrations). To evaluate performance, the 4-hr time-weighted average readings from the DROVMs in a given trial were compared with the average of two charcoal tube concentrations using pairwise comparison. The pairwise comparison criterion was +/-25% measurement agreement between each individual DROVM and the DROVMs as a group and the average charcoal tube concentration. The ppbRAE group performed the best with 40% of all readings meeting the comparison criterion followed by the SapphIRe group at 39%. Among individual DROVMs, the best performer was a SapphIRe, with 57% of its readings meeting the criterion. The data was further analyzed by temperature, humidity, and concentration. The results indicated the performance of some DROVMs may be affected by temperature, humidity, and/or concentration. The ppbRAE group performed best at 21 degrees C with the percentage of readings meeting the criterion increasing to 63%. At the 5 ppm concentration, 44% of the ppbRAE group readings met the criterion, while at 100 ppm, only 35% did. The results indicate that monitors can be used as survey tools. Based on the data, the inconsistent performance of these DROVMs may not allow them to be used for determining compliance with occupational exposure limits.
SN - 1545-9624
AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia.
U2 - PMID: 18949604.
DO - 10.1080/15459620802514728
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DB - rzh
ER -
TY - JOUR
AU - Saylor, David M.
AU - Chang-Soo Kim
AU - Patwardhan, Dinesh V.
AU - Warren, James A.
T1 - Modeling microstructure development and release kinetics in controlled drug release coatings.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2009/01//
VL - 98
IS - 1
M3 - Article
SP - 169
EP - 186
SN - 00223549
AB - In recent years, controlled release coatings, comprised of drug-polymer composites, have been integrated with medical devices, improving device functionality and performance. However, relationships between material properties, manufacturing environment, composite (micro)structure, and subsequent release kinetics are not well established. We apply a thermodynamically consistent model to probe the influence of drug-polymer chemistry (phobicity), drug loading, and evaporation rate on microstructure development during fabrication. For these structures, we compute release profiles for exposure to polymer-insoluble media and media in which the polymer readily dissolves. We find that with increasing drug-polymer phobicity, structural heterogeneities form at lower loadings and more rapid rates. The heterogeneities remain isolated and compact at low loadings and become interconnected as the drug to polymer ratio approaches 1.0. Release into polymer-insoluble media was dramatically enhanced by heterogeneities, resulting in up to a fourfold increase in drug release. In polymer-soluble media, however, heterogeneities diminished release. Although reductions of only 30% were typically observed, the absolute changes were much larger than observed in polymer-insoluble media. Our results suggest that improved comprehension and quantification of the physico-chemical properties in controlled release systems will enable the microstructure to be tailored to achieve desired responses that are insensitive to manufacturing variations. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:169–186, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROSTRUCTURE
KW - DYNAMICS
KW - MEDICAL equipment
KW - CONTROLLED drugs
KW - SURFACE coatings
KW - biodegradable polymers
KW - controlled release/delivery
KW - diffusion
KW - dissolution
KW - in silico modeling
KW - mathematical model
KW - solubility
KW - thermodynamics
N1 - Accession Number: 35499243; Saylor, David M. 1; Email Address: david.saylor@fda.hhs.gov Chang-Soo Kim 1 Patwardhan, Dinesh V. 1 Warren, James A. 2; Affiliation: 1: Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, Maryland 20903 2: National Institute of Standards and Technology, Materials Science and Engineering Laboratories, Metallurgy Division, Gaithersburg, Maryland 20899; Source Info: Jan2009, Vol. 98 Issue 1, p169; Subject Term: MICROSTRUCTURE; Subject Term: DYNAMICS; Subject Term: MEDICAL equipment; Subject Term: CONTROLLED drugs; Subject Term: SURFACE coatings; Author-Supplied Keyword: biodegradable polymers; Author-Supplied Keyword: controlled release/delivery; Author-Supplied Keyword: diffusion; Author-Supplied Keyword: dissolution; Author-Supplied Keyword: in silico modeling; Author-Supplied Keyword: mathematical model; Author-Supplied Keyword: solubility; Author-Supplied Keyword: thermodynamics; NAICS/Industry Codes: 325510 Paint and Coating Manufacturing; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 18p; Illustrations: 3 Diagrams, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1002/jps.21416
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gao, Zongming
AU - Moore, Terry W.
AU - Buhse, Lucinda F.
AU - Doub, William H.
T1 - The random vibration effects on dissolution testing with USP apparatus 2.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2009/01//
VL - 98
IS - 1
M3 - Article
SP - 297
EP - 306
SN - 00223549
AB - Dissolution testing is of primary importance for optimization of drug formulation and quality control, but test results typically show large variability. Vibration is one of the factors that can increase variability of dissolution testing. In this study, a Distek USP Apparatus 2 was used to perform dissolution testing using disintegrating 10 mg prednisone tablets at 50 rpm in 500 mL of 37°C degassed water medium. A controllable vertical random vibration was applied to the dissolution apparatus during the dissolution testing. Real-time vibration waveforms were recorded using accelerometers placed at various locations on the vessel plate and on the dissolution vessels. Preliminary results showed a strong correlation between induced vibration and dissolution results. The vibration measured on the vessel plate correlates well with that measured within nearby vessels. The observed dissolution profiles suggest that vibration affects the disintegration and dissolving processes by different mechanisms, leading to high or low results depending upon during which phase of the dissolution process the vibration occurs. This study also presents a method capable of measuring vibration in a meaningful manner and how to determine where best to measure it. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:297–306, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RANDOM vibration
KW - DRUGS
KW - EXCIPIENTS
KW - PREDNISONE
KW - QUALITY control
KW - disintegrating tablet
KW - dissolution testing
KW - prednisone tablet
KW - random vibration
KW - USP apparatus 2
N1 - Accession Number: 35499254; Gao, Zongming 1; Email Address: zongming.gao@fda.hhs.gov Moore, Terry W. 1 Buhse, Lucinda F. 1 Doub, William H. 1; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101; Source Info: Jan2009, Vol. 98 Issue 1, p297; Subject Term: RANDOM vibration; Subject Term: DRUGS; Subject Term: EXCIPIENTS; Subject Term: PREDNISONE; Subject Term: QUALITY control; Author-Supplied Keyword: disintegrating tablet; Author-Supplied Keyword: dissolution testing; Author-Supplied Keyword: prednisone tablet; Author-Supplied Keyword: random vibration; Author-Supplied Keyword: USP apparatus 2; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 2 Diagrams, 4 Charts, 6 Graphs; Document Type: Article
L3 - 10.1002/jps.21402
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stewart, Gernerique
AU - Jiao, Yuguo
AU - Valente, Edward J.
AU - Fu, Peter P.
AU - Li, Tianqiao
AU - Hu, Zhenzhong
AU - Yu, Hongtao
T1 - Photochemical reaction of 9-nitro-substituted anthracene-like molecules 9-methyl-10-nitroanthracene and 12-methyl-7-nitrobenz[a]anthracene
JO - Journal of Photochemistry & Photobiology A: Chemistry
JF - Journal of Photochemistry & Photobiology A: Chemistry
Y1 - 2009/01//
VL - 201
IS - 1
M3 - Article
SP - 39
EP - 44
SN - 10106030
AB - Abstract: Photolysis of 9-methyl-10-nitroanthracene in chloroform or methanol produces mainly two products 9-methyl-9-nitrosoanthracen-10-one and 9,10-anthraquinone in about 4:1 ratio under ambient air. The formation of 9-methyl-9-nitrosoanthracen-10-one confirms the proposed excited state rearrangement reaction of the nitro group peri to two hydrogens and perpendicular to the aromatic rings. The nitro group rearranges to a nitrite, followed by breaking of the N–O bond producing NO radical. The NO radical further forms a bond with the carbon on the opposite site of the benzene ring through radical recombination. Photolysis of 12-methyl-7-nitrobenz[a]anthracene produced several nitroso ketone-like compounds which further convert to an aldehyde. Photolysis of the desmethyl nitro compounds, 9-nitroanthracene and 7-nitrobenz[a]anthracene, produced the respective quinones. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology A: Chemistry is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTHRACENE
KW - CHEMICAL reactions
KW - PHOTOCHEMISTRY
KW - CHLOROFORM
KW - REARRANGEMENTS (Chemistry)
KW - QUINONE
KW - 7-Nitrobenz[a]anthracene, 12-Methyl-7-nitrobenz[a]anthracene
KW - 9-Methyl-10-nitroanthracene
KW - Nitro-rearrangement
KW - Photoreaction
N1 - Accession Number: 35926838; Stewart, Gernerique 1 Jiao, Yuguo 1,2 Valente, Edward J. 3 Fu, Peter P. 4 Li, Tianqiao 2 Hu, Zhenzhong 2 Yu, Hongtao 1; Email Address: yu@jsums.edu; Affiliation: 1: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA 2: College of Life and Environmental Science, Central University of Nationalities, Beijing 100081, China 3: Department of Chemistry and Biochemistry, Mississippi College, Clinton, MS 39058, USA 4: National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Jan2009, Vol. 201 Issue 1, p39; Subject Term: ANTHRACENE; Subject Term: CHEMICAL reactions; Subject Term: PHOTOCHEMISTRY; Subject Term: CHLOROFORM; Subject Term: REARRANGEMENTS (Chemistry); Subject Term: QUINONE; Author-Supplied Keyword: 7-Nitrobenz[a]anthracene, 12-Methyl-7-nitrobenz[a]anthracene; Author-Supplied Keyword: 9-Methyl-10-nitroanthracene; Author-Supplied Keyword: Nitro-rearrangement; Author-Supplied Keyword: Photoreaction; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jphotochem.2008.09.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Shuguang
AU - Wang, Lei
AU - Yin, Jun-Jie
AU - Wang, Zheng
AU - Fu, Peter P.
AU - Yu, Hongtao
T1 - Light-induced toxic effects of tamoxifen: A chemotherapeutic and chemopreventive agent
JO - Journal of Photochemistry & Photobiology A: Chemistry
JF - Journal of Photochemistry & Photobiology A: Chemistry
Y1 - 2009/01//
VL - 201
IS - 1
M3 - Article
SP - 50
EP - 56
SN - 10106030
AB - Abstract: Tamoxifen is a powerful drug used to treat breast cancer patients, and more than 500,000 women in the U.S. are being treated with this drug. In our study, tamoxifen is found to be photomutagenic in Salmonella typhimurium TA102 at concentrations as low as 0.08μM and reaches maximum photomutagenicity at 0.4μM under a light dose equivalent to 20min sunlight. These concentrations are comparable to the plasma tamoxifen concentration of 0.4–3μM for patients undergoing tamoxifen therapy. The toxicity seems to be the result of DNA damage and/or lipid peroxidation caused by light irradiation of tamoxifen. The DNA damage caused by irradiation of ФX174 DNA in the presence of tamoxifen appears to be formation of DNA–tamoxifen covalent adducts, not single strand/double strand cleavages, and there is no oxygen involvement. This is confirmed by EPR experiments that carbon-centerd radicals are formed by light irradiation of tamoxifen and there is no singlet oxygen formation. Although superoxide radical is formed, it is not involved in DNA damage. [Copyright &y& Elsevier]
AB - Copyright of Journal of Photochemistry & Photobiology A: Chemistry is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TAMOXIFEN
KW - DRUGS -- Physiological effect
KW - DRUG therapy
KW - BREAST cancer -- Treatment
KW - CHEMOPREVENTION
KW - DNA damage
KW - HaCaT keratinocytes
KW - Lipid peroxidation
KW - Phototoxicity
KW - Salmonella TA102
KW - Tamoxifen
N1 - Accession Number: 35926840; Wang, Shuguang 1 Wang, Lei 1 Yin, Jun-Jie 2 Wang, Zheng 1 Fu, Peter P. 3 Yu, Hongtao 1; Email Address: hongtao.yu@jsums.edu; Affiliation: 1: Department of Chemistry, Jackson State University, Jackson, MS 39217, United States 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, United States 3: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Source Info: Jan2009, Vol. 201 Issue 1, p50; Subject Term: TAMOXIFEN; Subject Term: DRUGS -- Physiological effect; Subject Term: DRUG therapy; Subject Term: BREAST cancer -- Treatment; Subject Term: CHEMOPREVENTION; Subject Term: DNA damage; Author-Supplied Keyword: HaCaT keratinocytes; Author-Supplied Keyword: Lipid peroxidation; Author-Supplied Keyword: Phototoxicity; Author-Supplied Keyword: Salmonella TA102; Author-Supplied Keyword: Tamoxifen; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jphotochem.2008.09.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35926840&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Make Time for Daily Physical Activity
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2009/01//
VL - 109
IS - 1
M3 - Editorial
SP - 18
EP - 18
SN - 00028223
N1 - Accession Number: 35927729; Galson, Steven K. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Jan2009, Vol. 109 Issue 1, p18; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2008.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35927729&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105641950
T1 - Risk of hepatitis B for travelers: is vaccination for all travelers really necessary?
AU - Sonder GJ
AU - van Rijckevorsel GG
AU - van den Hoek A
Y1 - 2009/01//Jan/Feb2009
N1 - Accession Number: 105641950. Language: English. Entry Date: 20090619. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9434456.
KW - Hepatitis B Vaccines -- Administration and Dosage
KW - Hepatitis B -- Epidemiology
KW - Hepatitis B -- Prevention and Control
KW - Immunization -- Utilization
KW - Public Health -- Prevention and Control
KW - Travel
KW - Adolescence
KW - Adult
KW - Aged
KW - Child
KW - Child, Preschool
KW - Female
KW - Immigrants
KW - Incidence
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Age
KW - Netherlands
KW - Retrospective Design
KW - Risk Factors
KW - Sentinel Event
KW - Human
SP - 18
EP - 22
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
JA - J TRAVEL MED
VL - 16
IS - 1
PB - Oxford University Press / USA
SN - 1195-1982
AD - Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands. gsonder@ggd.amsterdam.nl
U2 - PMID: 19192123.
DO - 10.1111/j.1708-8305.2008.00268.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105641950&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - van Atta, Philip
AU - Newsad, Robert
T1 - Water system preparedness and best practices for pandemic influenza.
JO - Journal: American Water Works Association
JF - Journal: American Water Works Association
Y1 - 2009/01//
VL - 101
IS - 1
M3 - Article
SP - 40
EP - 53
SN - 0003150X
AB - According to public health experts and the medical community, an influenza pandemic could occur at any time. The authors conducted a literature review, interviews, and a survey of Ohio water systems to assess how prepared US water systems were for a pandemic flu outbreak and found varying preparedness levels. In addition, the project determined the planning resources available for water systems and developed a template plan that systems could use for pandemic preparedness and response. In addition to triggering supply disruptions for power, chemicals, and equipment, a pandemic flu could result in serious staffing problems for water systems, with illness and family care issues creating staffing shortages up to 40%. Cross-training for essential positions, sequestering critical employees, and implementing vaccination and other personal protection measures would be essential to maintaining adequate levels of staffing during a pandemic. The article also discusses best practices and other strategies to improve utility contingency planning. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal: American Water Works Association is the property of American Water Works Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Water -- Management
KW - Public health
KW - Water quality
KW - Influenza viruses
KW - Preparedness
KW - Strategic planning
KW - Health surveys
KW - Project management
KW - United States
N1 - Accession Number: 36315743; van Atta, Philip 1; Email Address: phil.vanatta@cityofdayton.og; Newsad, Robert 2; Affiliations: 1: City of Dayton Water Department, 3210 Chuck Wagner Ln., Dayton, OH; 2: US Public Health Service, Sacramento, Calif.; Issue Info: Jan2009, Vol. 101 Issue 1, p40; Thesaurus Term: Water -- Management; Thesaurus Term: Public health; Thesaurus Term: Water quality; Subject Term: Influenza viruses; Subject Term: Preparedness; Subject Term: Strategic planning; Subject Term: Health surveys; Subject Term: Project management; Subject: United States; NAICS/Industry Codes: 541611 Administrative Management and General Management Consulting Services; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 541619 Other management consulting services; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 14p; Illustrations: 4 Color Photographs, 2 Diagrams, 7 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2008-08224-004
AN - 2008-08224-004
AU - Reger, Greg M.
AU - Moore, Bret A.
ED - Freeman, Sharon Morgillo
ED - Moore, Bret A.
ED - Freeman, Arthur
ED - Freeman, Sharon Morgillo, (Ed)
ED - Moore, Bret A., (Ed)
ED - Freeman, Arthur, (Ed)
T1 - Challenges and threats of deployment.
T2 - Living and surviving in harm's way: A psychological treatment handbook for pre- and post-deployment of military personnel.
Y1 - 2009///
SP - 51
EP - 65
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-98868-1
N1 - Accession Number: 2008-08224-004. Partial author list: First Author & Affiliation: Reger, Greg M.; National Center for Telehealth and Technology, Defense Centers of Excellence for Psychological Health and Traumatic Brain Injury, US. Release Date: 20091102. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-415-98868-1, Hardcover. Language: English. Major Descriptor: Combat Experience; Military Deployment; Military Personnel; Occupational Stress. Minor Descriptor: Health Care Delivery; Primary Mental Health Prevention. Classification: Military Psychology (3800); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 15.
AB - Although there are no quick fixes to the challenges service members and their families face, military personnel encounter common challenges, and planning for those challenges may help mitigate the negative impact. Some of these challenges present long before the unit leaves for deployment. Other challenges occur during the deployment, and still others follow the return home. The purpose of this chapter is to review some of these challenges and to offer practical suggestions that can be utilized to assist those going into harm's way. Other discussions of combat stress may also be relevant to the reader (U.S. Department of the Army, 1994; U.S. Marine Corps, 2000; Nash, 2007). This chapter is not intended to be a comprehensive review of all deployment challenges but rather to highlight the most common challenges, based on the experience of the authors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - deployment
KW - military personnel
KW - combat stress
KW - care delivery
KW - prevention
KW - 2009
KW - Combat Experience
KW - Military Deployment
KW - Military Personnel
KW - Occupational Stress
KW - Health Care Delivery
KW - Primary Mental Health Prevention
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08224-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-08224-010
AN - 2008-08224-010
AU - Freeman, Arthur
AU - Moore, Bret A.
ED - Freeman, Sharon Morgillo
ED - Moore, Bret A.
ED - Freeman, Arthur
ED - Freeman, Sharon Morgillo, (Ed)
ED - Moore, Bret A., (Ed)
ED - Freeman, Arthur, (Ed)
T1 - Theoretical base for treatment of military personnel.
T2 - Living and surviving in harm's way: A psychological treatment handbook for pre- and post-deployment of military personnel.
Y1 - 2009///
SP - 171
EP - 192
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-98868-1
N1 - Accession Number: 2008-08224-010. Partial author list: First Author & Affiliation: Freeman, Arthur; Governors State University, University Park, IL, US. Release Date: 20091102. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-415-98868-1, Hardcover. Language: English. Major Descriptor: Cognitive Behavior Therapy; Health Care Delivery; Military Personnel; Theories. Classification: Military Psychology (3800); Cognitive Therapy (3311). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - The values, training, culture, and ethos of the military are well described throughout this volume. Our goal in this chapter is to describe a specific cognitive-behavioral psychotherapeutic treatment model that has been developed and used with a broad range of clinical populations and clinical problems and in a range of settings and situations. We first offer a brief introduction to cognitive-behavioral therapy (CBT) and then discuss assessment, treatment conceptualization, and treatment planning. The next part addresses specific cognitive, affective, behavioral, and situational factors. Finally, we offer a clinical example and a summary of the multiple problems encountered by returning service members. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment
KW - military personnel
KW - cognitive-behavioral psychotherapeutic treatment model
KW - cognitive-behavioral therapy
KW - CBT
KW - 2009
KW - Cognitive Behavior Therapy
KW - Health Care Delivery
KW - Military Personnel
KW - Theories
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08224-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-08224-015
AN - 2008-08224-015
AU - Moore, Bret A.
AU - Krakow, Barry
ED - Freeman, Sharon Morgillo
ED - Moore, Bret A.
ED - Freeman, Arthur
ED - Freeman, Sharon Morgillo, (Ed)
ED - Moore, Bret A., (Ed)
ED - Freeman, Arthur, (Ed)
T1 - Characteristics, effects, and treatment of sleep disorders in service members.
T2 - Living and surviving in harm's way: A psychological treatment handbook for pre- and post-deployment of military personnel.
Y1 - 2009///
SP - 281
EP - 306
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-98868-1
N1 - Accession Number: 2008-08224-015. Partial author list: First Author & Affiliation: Moore, Bret A.; Indian Health Service, Ft. Peck, MT, US. Release Date: 20091102. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-415-98868-1, Hardcover. Language: English. Major Descriptor: Evidence Based Practice; Military Personnel; Sleep Disorders; Treatment. Minor Descriptor: Sleep Apnea. Classification: Health & Mental Health Treatment & Prevention (3300); Military Psychology (3800). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 26.
AB - The main goals of this chapter are to give the practitioner who treats service members a better understanding of sleep disorders, information on how sleep disorders impact the men and women of our Armed Forces, and guidance on effective and practical methods of treatment. Although no sleep disorders exclusively arise in service members, this population manifests unique assessment and treatment issues. A brief review of sleep architecture precedes a focused discussion on the characteristics of sleep disorders and the evidence-based strategies for their effective management. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - treatment
KW - sleep disorders
KW - service members
KW - Armed Forces
KW - evidence-based strategies
KW - sleep apnea
KW - 2009
KW - Evidence Based Practice
KW - Military Personnel
KW - Sleep Disorders
KW - Treatment
KW - Sleep Apnea
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08224-015&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-08224-016
AN - 2008-08224-016
AU - Moore, Bret A.
AU - Hopewell, C. Alan
AU - Grossman, Dave
ED - Freeman, Sharon Morgillo
ED - Moore, Bret A.
ED - Freeman, Arthur
ED - Freeman, Sharon Morgillo, (Ed)
ED - Moore, Bret A., (Ed)
ED - Freeman, Arthur, (Ed)
T1 - After the battle: Violence and the warrior.
T2 - Living and surviving in harm's way: A psychological treatment handbook for pre- and post-deployment of military personnel.
Y1 - 2009///
SP - 307
EP - 327
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-98868-1
N1 - Accession Number: 2008-08224-016. Partial author list: First Author & Affiliation: Moore, Bret A.; Indian Health Service, Ft. Peck, MT, US. Release Date: 20091102. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-415-98868-1, Hardcover. Language: English. Major Descriptor: Combat Experience; Military Veterans; Occupational Stress; Violence. Classification: Military Psychology (3800). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 21.
AB - Much of the content of this chapter is based on the highly acclaimed book On Combat: The Psychology and Physiology of Deadly Conflict in War and in Peace, by Lt. Col. (Ret.) Dave Grossman and Loren W. Christensen. The problem here is delineation of a truthful estimate of the amount, severity, and nature of violence that may occur among combat veterans and devising an accurate way to identify, treat, and predict such trends without embellishment for political gain, unwarranted mitigation to avoid personal responsibility, or the disparagement of true heroes. This chapter, therefore, reviews the factors that contribute to violence, how this may occur in a veteran population, how to avoid the excesses of the 'Whacko Vet' myths, and how to identify and intervene effectively in such disorders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - violence
KW - combat veterans
KW - combat
KW - stress
KW - 2009
KW - Combat Experience
KW - Military Veterans
KW - Occupational Stress
KW - Violence
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08224-016&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2008-08224-017
AN - 2008-08224-017
AU - Freeman, Sharon Morgillo
AU - Lundt, Leslie
AU - Swanton, Edward J.
AU - Moore, Bret A.
ED - Freeman, Sharon Morgillo
ED - Moore, Bret A.
ED - Freeman, Arthur
ED - Freeman, Sharon Morgillo, (Ed)
ED - Moore, Bret A., (Ed)
ED - Freeman, Arthur, (Ed)
T1 - Myths and realities of pharmacotherapy in the military.
T2 - Living and surviving in harm's way: A psychological treatment handbook for pre- and post-deployment of military personnel.
Y1 - 2009///
SP - 329
EP - 346
CY - New York, NY, US
PB - Routledge/Taylor & Francis Group
SN - 978-0-415-98868-1
N1 - Accession Number: 2008-08224-017. Partial author list: First Author & Affiliation: Freeman, Sharon Morgillo; Center for Brief Therapy, Freeman International Institute, Fort Wayne, IN, US. Release Date: 20091102. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-0-415-98868-1, Hardcover. Language: English. Major Descriptor: Drug Therapy; Military Personnel; Military Psychology; Organizational Climate. Classification: Clinical Psychopharmacology (3340); Military Psychology (3800). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 18.
AB - The goal of this chapter is to assist the civilian practitioner to understand the importance of military culture and its impact on the service member before considering medication as a treatment option. Each situation requires an understanding of that service member's duty status, job description, and potential for activation into military duty both at home and abroad. As the choice of pharmacologic agent may have a significant impact on the service member's career, the mental health practitioner must choose wisely between psychological interventions only and categories of medication that may be considered nonpsychiatric, or psychiatric depending on the situation at hand. The overriding goal is always to keep our service members safe and, as a result, our civilians, safe. The mental health practitioner must walk a fine line when treating one of these heroes, but they must keep in mind that while treating these brave men and women it is important to help them maintain their courage, self-esteem, and, whenever possible, careers. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pharmacotherapy
KW - military
KW - military culture
KW - service member
KW - mental health practitioner
KW - 2009
KW - Drug Therapy
KW - Military Personnel
KW - Military Psychology
KW - Organizational Climate
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-08224-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Lee, Ju Woon
AU - Kim, Jae Kyung
AU - Srinivasan, Periasamy
AU - Choi, Jong-il
AU - Kim, Jae Hun
AU - Han, Sang Bae
AU - Kim, Duk-Jin
AU - Byun, Myung Woo
T1 - Effect of gamma irradiation on microbial analysis, antioxidant activity, sugar content and color of ready-to-use tamarind juice during storage
JO - LWT - Food Science & Technology
JF - LWT - Food Science & Technology
Y1 - 2009/01//
VL - 42
IS - 1
M3 - Article
SP - 101
EP - 105
SN - 00236438
AB - Abstract: Gamma irradiation is highly effective in inactivating microorganisms in various foods and it offers a safe alternative method of food decontamination. In the present study, the effect of gamma irradiation on microbial analysis, antioxidant activity, sugar content, color and sensory evaluation of ready-to-use tamarind juice was investigated during storage. A fresh tamarind juice was prepared by dissolving 5g of pulp/100ml of deionized distilled water and irradiated at 0, 1, 3 and 5kGy at room temperature. Microbiological assay of the fresh and stored ready-to-use tamarind juice showed better quality after gamma irradiation. Antioxidant ability was studied by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), FRAP (ferric reducing/antioxidant power) and total phenolic contents, and gamma irradiation had a significant increase or maintenance on the antioxidant potential of the ready-to-use tamarind juice. Contents of glucose and fructose also showed minimal alterations both in the fresh and stored samples. There was a significant improvement in the Hunter color value in both the fresh and stored tamarind juice. To conclude, gamma irradiation improves the microbial decontamination and the antioxidants as well as the color of the ready-to-use tamarind juice without any adverse change in sensory qualities. [Copyright &y& Elsevier]
AB - Copyright of LWT - Food Science & Technology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SENSORY evaluation
KW - IRRADIATION
KW - FOOD -- Testing
KW - FOOD -- Sensory evaluation
KW - Antioxidant activity
KW - Gamma irradiation
KW - Microbial decontamination
KW - Ready-to-use tamarind juice
KW - Sensory evaluation
N1 - Accession Number: 34665503; Lee, Ju Woon 1; Email Address: sjwlee@kaeri.re.kr Kim, Jae Kyung 1 Srinivasan, Periasamy 1 Choi, Jong-il 1 Kim, Jae Hun 1 Han, Sang Bae 2 Kim, Duk-Jin 3 Byun, Myung Woo 1; Affiliation: 1: Radiation Food Science and Biotechnology Team, Advance Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup 580-185, South Korea 2: Food and Risk Standardization Team, The Bureau of Risk Management, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu 122-704, Seoul, South Korea 3: Department of Food Science and Engineering, Daegu University, 15 Naeri, Jillyang, Gyeongsan, Gyeongbuk 712-714, South Korea; Source Info: Jan2009, Vol. 42 Issue 1, p101; Subject Term: SENSORY evaluation; Subject Term: IRRADIATION; Subject Term: FOOD -- Testing; Subject Term: FOOD -- Sensory evaluation; Author-Supplied Keyword: Antioxidant activity; Author-Supplied Keyword: Gamma irradiation; Author-Supplied Keyword: Microbial decontamination; Author-Supplied Keyword: Ready-to-use tamarind juice; Author-Supplied Keyword: Sensory evaluation; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.lwt.2008.06.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34665503&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105609131
T1 - The utility of prediction models to oversample the long-term uninsured.
AU - Cohen SB
AU - Yu WW
Y1 - 2009/01//2009 Jan
N1 - Accession Number: 105609131. Language: English. Entry Date: 20090220. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Health Care Costs -- Statistics and Numerical Data
KW - Insurance Coverage -- Trends
KW - Medically Uninsured -- Statistics and Numerical Data
KW - Models, Statistical
KW - Surveys
KW - Adolescence
KW - Adult
KW - Cost Benefit Analysis
KW - Health Care Costs -- Trends
KW - Health Services Accessibility -- Economics
KW - Insurance Coverage -- Statistics and Numerical Data
KW - Logistic Regression
KW - Middle Age
KW - Patient Attitudes -- Ethnology
KW - Patient Attitudes
KW - Probability Sample
KW - Probability
KW - Sensitivity and Specificity
KW - Socioeconomic Factors
KW - Time Factors
KW - United States
KW - Human
SP - 80
EP - 87
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVES: To evaluate the performance of prediction models in identifying the long-term uninsured and their utility for oversampling purposes in national health care surveys. DATA AND METHODS: Nationally representative data from the Medical Expenditure Panel Survey (MEPS) were used to examine national estimates of nonelderly adults without health insurance coverage for 2 consecutive years and to identify the factors that distinguished them from the short-term uninsured and those who are continually insured. The MEPS data were also used in the development of the prediction models to identify individuals most likely to experience long-term spells without coverage in the future. The prediction models were developed using data from the MEPS panel covering 2004-2005 and evaluated with an independent MEPS panel. RESULTS: Study findings revealed these prediction models to be markedly effective statistical tools in facilitating an efficient over-sample of individuals likely to be uninsured for long periods of duration in the future. Use of these models for oversampling purposes, to support a 50% increase in sample yield over a self-weighting design, permits the selection of the target sample of individuals who are continuously uninsured for 2 consecutive years in the most cost-efficient manner. This methodology allows for an overall sample size specification for nonelderly adults that is at least 25% lower than a design without access to the predictor variables from a screening interview or without application of oversampling techniques. CONCLUSIONS: This examination of the performance of probabilistic models, to both identify and facilitate an oversample of the long-term uninsured, demonstrates the viability of these model-based sampling methodologies for adoption in national health care surveys.
SN - 0025-7079
AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. scohen@ahrq.gov
U2 - PMID: 19106735.
DO - 10.1097/MLR.0b013e3181844e2e
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105609131&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - CHAP
ID - 2009-01377-013
AN - 2009-01377-013
AU - Rodriguez, Jesse S.
AU - Paule, Merle G.
ED - Buccafusco, Jerry J.
ED - Buccafusco, Jerry J., (Ed)
T1 - Working memory: Delayed response tasks in monkeys.
T2 - Methods of behavioral analysis in neuroscience, 2nd ed.
T3 - Frontiers in neuroscience
Y1 - 2009///
SP - 247
EP - 265
CY - Boca Raton, FL, US
PB - CRC Press
SN - 978-1-4200-5234-3
N1 - Accession Number: 2009-01377-013. Partial author list: First Author & Affiliation: Rodriguez, Jesse S.; National Center for Toxicological Research, Division of Neurotoxicology, Jefferson, AR, US. Release Date: 20090706. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-1-4200-5234-3, Hardcover. Language: English. Major Descriptor: Animal Models; Reaction Time; Short Term Memory. Minor Descriptor: Monkeys. Classification: Animal Experimental & Comparative Psychology (2400). Population: Animal (20). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 19.
AB - Accepted taxonomies of memory typically distinguish among different kinds of remembering depending upon the information that must be remembered. A basic dichotomy distinguishes between the retention of factual or experiential information on the one hand, and the retention of habits and motor skills on the other. Factual memory can be further differentiated into working and reference memory. As first described by Werner Honig's group, working memory is required when 'different stimuli govern the criterion response on different trials, so that the cue that the animal must remember varies from trial to trial.' Thus, working memory is required for remembering information that varies unpredictably in time and/or in content: it is this type of memory that is decimated in Alzheimer's disease and other dementias. In contrast, reference memory is used to retain information that remains constant over time (e.g., removing the cup from a baited well provides access to food). The study of working memory processes is generally accomplished using delayed response (DR) tasks and, within the confines of even relatively short test sessions, one can readily assess processes associated with short-term memory using these DR tasks using nonhuman primates as surrogates are used primarily to determine the biological underpinnings of human learning and memory processes and their associated mechanisms. The complex brain functions associated with the performance of these tasks can be assessed using a variety of approaches, and the careful monitoring of behavioral outputs provides important experimental advantages. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - working memory
KW - delayed response tasks
KW - monkeys
KW - animal models
KW - 2009
KW - Animal Models
KW - Reaction Time
KW - Short Term Memory
KW - Monkeys
KW - 2009
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Bhagwat, Arvind A.
AU - Won Jun
AU - Liu Liu
AU - Kannan, Porteen
AU - Dharne, Mahesh
AU - Pheh, Benedict
AU - Tall, Ben D.
AU - Kothary, Mahendra H.
AU - Gross, Kenneth C.
AU - Angle, Scott
AU - Jianghong Meng
AU - Smith, Allen
T1 - Osmoregulated periplasmic glucans of Salmonella enterica serovar Typhimurium are required for optimal virulence in mice.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2009/01//
VL - 155
IS - 1
M3 - Article
SP - 229
EP - 237
SN - 13500872
AB - The article presents a study on the osmoregulated periplasmic glucans of Salmonella enterica serovar Typhimurium. In this research, osmoregulated periplasmic glucans (OPGs) from Salmonella enterica serovar Typhimurium were purified and found to be composed of 100 percent glucose with 2-linked glucose as the most abundant residue, with terminal glucose occurring in high quantities. Data from biosynthesis shows that OPGs of S. Typhimurium contribute towards virulence as well growth and motility under low osmolarity growth conditions.
KW - Salmonella
KW - Glucans
KW - Virulence (Microbiology)
KW - Microbiology
KW - Biosynthesis
KW - Osmoregulation
KW - Salmonella typhimurium
KW - Glucose
KW - Motility of bacteria
N1 - Accession Number: 36507780; Bhagwat, Arvind A. 1; Email Address: arvind.bhagwat@ars.usda.gov; Won Jun 1,2,3; Liu Liu 1,4,5; Kannan, Porteen 1; Dharne, Mahesh 1; Pheh, Benedict 1,6; Tall, Ben D. 7; Kothary, Mahendra H. 7; Gross, Kenneth C. 1; Angle, Scott 8,9; Jianghong Meng 4; Smith, Allen 10; Affiliations: 1: Produce Quality and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, 10300 Baltimore Avenue, Bldg. 002, BARC-W, Beltsville, MD 20705-235, USA; 2: Department of Plant Science & Landscape Architecture, University of Maryland, College Park, MD 20742-7521, USA; 3: Food Safety Laboratory, USDA-ARS, Beltsville, MD 20705, USA; 4: Department of Food Science and Nutrition, University of Maryland, College Park, MD 20742-7521, USA; 5: North-west A&F University, Yangling, PR China; 6: School of Life Sciences and Chemical Technology, Ngee Ann Polytechnic, Singapore 599489; 7: Food and Drug Administration, Division of Virulence Assessment, Laurel, MD 20708, USA; 8: College of Agriculture, University of Maryland, College Park, MD 20742-7521, USA; 9: College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA; 10: Diet Genomics and Immunology Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, 10300 Baltimore Avenue, Bldg. 002, BARC-W, Beltsville, MD 20705-2350, USA; Issue Info: Jan2009, Vol. 155 Issue 1, p229; Thesaurus Term: Salmonella; Thesaurus Term: Glucans; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Microbiology; Thesaurus Term: Biosynthesis; Subject Term: Osmoregulation; Subject Term: Salmonella typhimurium; Subject Term: Glucose; Subject Term: Motility of bacteria; Number of Pages: 9p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1099/mic.0.023747-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tournas, V. H.
T1 - Evaluation of the Hydrophobic Grid Membrane Filter for the Enumeration of Moulds and Yeasts in Naturally-Contaminated Foods.
JO - Microbiology Insights
JF - Microbiology Insights
Y1 - 2009/01//
IS - 2
M3 - Article
SP - 31
EP - 37
SN - 11786361
AB - Over 240 food samples from six food groups (tree nuts, grains and grain products, dried fruits, fresh produce, fruit juice, and dairy products) were tested for levels of fungal contamination using the NEO-GRID hydrophobic grid membrane filter (HGMF) and the FDA official (BAM) method. Results showed that HGMF performed very well for all tested commodities giving yeast and mould (YM) counts similar to those of the BAM (reference) method. Statistical analysis of the data (t-test) revealed no significant differences between the two methods for all foods tested. Regression analysis showed that there was a good fit linear relationship between the two methods for most of the commodities examined. Some difficulties were encountered during counting of the colonies on HGMF since the size of the grid is very small and the number of possible colonies per plate can reach 1600. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbiology Insights is the property of Libertas Academica Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD contamination
KW - HYDROPHOBIC surfaces
KW - YEAST
KW - MOLDS (Cookware)
KW - DAIRY products -- Contamination
KW - FRUIT -- Contamination
KW - REGRESSION analysis
KW - FOOD -- Safety measures
KW - UNITED States
KW - BAM method
KW - hydrophobic grid membrane filter
KW - yeast and mould quantification
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 50375609; Tournas, V. H. 1; Email Address: valerie.tournas@fda.hhs.gov; Affiliation: 1: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: 2009, Issue 2, p31; Subject Term: FOOD contamination; Subject Term: HYDROPHOBIC surfaces; Subject Term: YEAST; Subject Term: MOLDS (Cookware); Subject Term: DAIRY products -- Contamination; Subject Term: FRUIT -- Contamination; Subject Term: REGRESSION analysis; Subject Term: FOOD -- Safety measures; Subject Term: UNITED States; Author-Supplied Keyword: BAM method; Author-Supplied Keyword: hydrophobic grid membrane filter; Author-Supplied Keyword: yeast and mould quantification; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311990 All other food manufacturing; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Williamson, Donald A.
AU - Bathalon, Gaston P.
AU - Sigrist, Lori D.
AU - Allen, H. Raymond
AU - Frledl, Karl E.
AU - Young, Andrew J.
AU - Martin, Corby K.
AU - Stewart, Tiffany M.
AU - Burrell, Lolita
AU - Hongmei Han
AU - Hubbard, Van S.
AU - Ryan, Donna
T1 - Military Services Fitness Database: Development of a Computerized Physical Fitness and Weight Management Database for the U.S. Army.
JO - Military Medicine
JF - Military Medicine
Y1 - 2009/01//
VL - 174
IS - 1
M3 - Article
SP - 1
EP - 8
PB - AMSUS
SN - 00264075
AB - Department of Defense (DoD) has mandated development of a system to collect and manage data on the weight, percent body fat (%BF), and fitness of all military personnel. This project aimed to (1) develop a computerized weight and fitness database to track individuals and Army units over lime allowing cross-sectional and longitudinal evaluations and (2) test the computerized system for feasibility and integrity of data collection over several years of usage. The computer application, the Military Services Fitness Database (MSFD), was designed for (1) storage and tracking of data related to height, weight, %BF tot the Army Weight Control Program (AWCP) and Army Physical Fitness Test (APFT) scores and (2) generation of reports using these data. A 2.5-year pilot test of the MSFD indicated that it monitors population and individual trends of changing body weight, %BF, and fitness in a military population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DATABASES
KW - PHYSICAL fitness
KW - BODY weight
KW - MILITARY personnel -- United States
KW - UNITED States
KW - UNITED States. Army
KW - UNITED States. Dept. of Defense
N1 - Accession Number: 36187631; Williamson, Donald A. 1 Bathalon, Gaston P. 2 Sigrist, Lori D. 2 Allen, H. Raymond 1 Frledl, Karl E. 2 Young, Andrew J. 2 Martin, Corby K. 1 Stewart, Tiffany M. 1 Burrell, Lolita 2 Hongmei Han 1 Hubbard, Van S. 3 Ryan, Donna 1; Affiliation: 1: Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124 2: U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007 3: Public Health Service, Bethesda, MD 20817-5461; Source Info: Jan2009, Vol. 174 Issue 1, p1; Subject Term: DATABASES; Subject Term: PHYSICAL fitness; Subject Term: BODY weight; Subject Term: MILITARY personnel -- United States; Subject Term: UNITED States; Company/Entity: UNITED States. Army Company/Entity: UNITED States. Dept. of Defense; NAICS/Industry Codes: 713940 Fitness and Recreational Sports Centers; NAICS/Industry Codes: 928110 National Security; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Griggs, Robert C.
AU - Batshaw, Mark
AU - Dunkle, Mary
AU - Gopal-Srivastava, Rashmi
AU - Kaye, Edward
AU - Krischer, Jeffrey
AU - Nguyen, Tan
AU - Paulus, Kathleen
AU - Merkel, Peter A.
T1 - Clinical research for rare disease: Opportunities, challenges, and solutions
JO - Molecular Genetics & Metabolism
JF - Molecular Genetics & Metabolism
Y1 - 2009/01//
VL - 96
IS - 1
M3 - Article
SP - 20
EP - 26
SN - 10967192
AB - Abstract: Over 7000 rare diseases, each <200,000 US residents, affect nearly 30 million people in the United States. Furthermore, for the 10% of people with a rare disease and for their families, these disorders no longer seem rare. Molecular genetics have characterized the cause of many rare diseases and provide unprecedented opportunities for identifying patients, determining phenotypes, and devising treatments to prevent, stabilize, or improve each disease. Rare disease research poses challenges to investigators requiring specific approaches to: (1) the design of clinical studies; (2) the funding of research programs; (3) the discovery, testing, and approval of new treatments, and (4) the training of clinical scientists. Rigorous, statistically-valid, natural history-controlled, cross-over, and n-of-1 trials can establish efficacy and support regulatory approval of new treatments for rare diseases. The U.S. Orphan Drug Act of the U.S. FDA has stimulated industry investment in clinical trials to develop treatments for rare diseases. For trainees interested in finding a treatment for a rare disease, a commitment to longitudinal care of patients provides a base for the characterization of phenotype and natural history, a stimulus for innovation, a target population for research and helps fund training and research. The scientific methodology, financial resources, and logistics of clinical research for rare diseases have changed dramatically in the past two decades resulting in increased understanding of the pathophysiology of these disorders and direct benefit to patients. [Copyright &y& Elsevier]
AB - Copyright of Molecular Genetics & Metabolism is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RARE diseases
KW - RESEARCH
KW - HUMAN molecular genetics
KW - PHENOTYPE
KW - PATIENT advocacy
KW - MEDICAL scientists
KW - CLINICAL trials
KW - TRAINING of
KW - UNITED States
KW - Clinical trials
KW - Patient advocacy groups (PAGs)
KW - Rare diseases
KW - Research training
N1 - Accession Number: 35817419; Griggs, Robert C. 1; Email Address: Robert_griggs@urmc.rochester.edu Batshaw, Mark 2 Dunkle, Mary 3 Gopal-Srivastava, Rashmi 4 Kaye, Edward 5 Krischer, Jeffrey 6 Nguyen, Tan 7 Paulus, Kathleen 6 Merkel, Peter A. 8; Affiliation: 1: Department of Neurology, University of Rochester, 1351 Mt. Hope Avenue, Suite 203, Rochester, NY 14620, USA 2: Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970, USA 3: National Organization for Rare Disorders (NORD), P.O. Box 1968, 55 Kenosia Avenue, Danbury, CT 06813-1968, USA 4: Office of Rare Diseases, National Institutes of Health, 6100 Executive Boulevard, Room 3B01, Bethesda, MD, USA 5: Genzyme Corporation, 500 Kendall Street, Canbridge, MA 02142-1108, USA 6: Data Technology Coordination Office, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL 33612, USA 7: Office of In Vitro Diagnostics, Food and Drug Administration Parklawn Building, Room 6A55, HF-35, 5600 Fishers Lane, Rockville, MD 20857, USA 8: Section of Rheumatology and the Clinical Epidemiology Unit, Vasculitis Center, E5, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA; Source Info: Jan2009, Vol. 96 Issue 1, p20; Subject Term: RARE diseases; Subject Term: RESEARCH; Subject Term: HUMAN molecular genetics; Subject Term: PHENOTYPE; Subject Term: PATIENT advocacy; Subject Term: MEDICAL scientists; Subject Term: CLINICAL trials; Subject Term: TRAINING of; Subject Term: UNITED States; Author-Supplied Keyword: Clinical trials; Author-Supplied Keyword: Patient advocacy groups (PAGs); Author-Supplied Keyword: Rare diseases; Author-Supplied Keyword: Research training; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ymgme.2008.10.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wei Liu
AU - Jinhui Ding
AU - Gibbs, Jesse Raphael
AU - Sue Jane Wang
AU - Hardy, John
AU - Singleton, Andrew
T1 - A simple and efficient algorithm for genome-wide homozygosity analysis in disease.
JO - Molecular Systems Biology
JF - Molecular Systems Biology
Y1 - 2009/01//
VL - 5
IS - 1
M3 - Article
SP - 304
SN - 17444292
AB - Here we propose a simple statistical algorithm for rapidly scoring loci associated with disease or traits due to recessive mutations or deletions using genome-wide single nucleotide polymorphism genotyping case–control data in unrelated individuals. This algorithm identifies loci by defining homozygous segments of the genome present at significantly different frequencies between cases and controls. We found that false positive loci could be effectively removed from the output of this procedure by applying different physical size thresholds for the homozygous segments. This procedure is then conducted iteratively using random sub-datasets until the number of selected loci converges. We demonstrate this method in a publicly available data set for Alzheimer′s disease and identify 26 candidate risk loci in the 22 autosomes. In this data set, these loci can explain 75% of the genetic risk variability of the disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Systems Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALGORITHMS
KW - MUTATION (Biology)
KW - GENETIC polymorphisms
KW - ALZHEIMER'S disease
KW - GENOMES
KW - disease network
KW - homozygous segments
KW - risk loci
KW - statistical algorithm
KW - whole-genome screening
N1 - Accession Number: 47712616; Wei Liu 1,2; Email Address: Wei.Liu@fda.hhs.gov Jinhui Ding 1 Gibbs, Jesse Raphael 1,3 Sue Jane Wang 2 Hardy, John 3 Singleton, Andrew 1; Affiliation: 1: Laboratory of Neurogenetics, NIA, Porter Neuroscience Building, NIH Main Campus, Bethesda, MD, USA. 2: Office of Biostatistics, OTS, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. 3: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, Queen Square, London, UK.; Source Info: 2009, Vol. 5 Issue 1, p304; Subject Term: ALGORITHMS; Subject Term: MUTATION (Biology); Subject Term: GENETIC polymorphisms; Subject Term: ALZHEIMER'S disease; Subject Term: GENOMES; Author-Supplied Keyword: disease network; Author-Supplied Keyword: homozygous segments; Author-Supplied Keyword: risk loci; Author-Supplied Keyword: statistical algorithm; Author-Supplied Keyword: whole-genome screening; Number of Pages: 1p; Illustrations: 1 Diagram, 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/msb.2009.53
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2009-12181-015
AN - 2009-12181-015
AU - Ridenour, Marilyn L.
AU - Cummings, Kristin J.
AU - Sinclair, Julie R.
AU - Bixler, Danae
ED - Brennan, Virginia M.
ED - Brennan, Virginia M., (Ed)
T1 - Displacement of the underserved: Medical needs of Hurricane Katrina evacuees in West Virginia.
T2 - Natural disasters and public health: Hurricanes Katrina, Rita, and Wilma.
Y1 - 2009///
SP - 156
EP - 168
CY - Baltimore, MD, US
PB - Johns Hopkins University Press
SN - 0-8018-9199-X
SN - 978-0-8018-9199-1
N1 - Accession Number: 2009-12181-015. Partial author list: First Author & Affiliation: Ridenour, Marilyn L.; National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20091116. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 0-8018-9199-X, Paperback; 978-0-8018-9199-1, Paperback. Language: English. Major Descriptor: Health Service Needs; Housing; Natural Disasters; Public Health; Health Personnel. Minor Descriptor: Volunteers. Classification: Environmental Issues & Attitudes (4070); Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). Methodology: Empirical Study; Qualitative Study. Page Count: 13.
AB - Hurricane Katrina displaced approximately one million people from the Gulf Coast region. Evacuation centers were established in the affected states as well as neighboring Texas, which sheltered an estimated 250,000 evacuees in the days following the storm. The response ultimately took on a national scope, with over 1,000 evacuation centers in 27 states involved. This chapter reports on the experiences at one of those evacuation centers in the state of West Virginia. West Virginia is a landlocked, mountainous state approximately 1,000 miles from the Gulf Coast. Evacuees arrived in the state capitol of Charleston by air, and then traveled approximately 165 miles by bus to the evacuation center. The evacuation center was established at an Army National Guard Training Site Command with ongoing activities and provided temporary housing for the evacuees. More than 300 evacuees arrived at the evacuation center between September 4-7, 2005. Relief workers at the evacuation center included Red Cross volunteers; local, state, and national public health personnel; and representatives of other community groups. The center was operational until October 1, 2005, at which point all evacuees had, with Red Cross assistance, found alternative housing. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public health personnel
KW - alternative housing
KW - evacuation centers
KW - temporary housing
KW - West Virginia
KW - Hurricane Katrina
KW - displaced evacuees
KW - medical needs
KW - 2009
KW - Health Service Needs
KW - Housing
KW - Natural Disasters
KW - Public Health
KW - Health Personnel
KW - Volunteers
KW - 2009
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DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Rathore, Anurag S
AU - Winkle, Helen
T1 - Quality by design for biopharmaceuticals.
JO - Nature Biotechnology
JF - Nature Biotechnology
Y1 - 2009/01//
VL - 27
IS - 1
M3 - Article
SP - 26
EP - 34
SN - 10870156
AB - The article discusses the "quality by design" (QbD) process, offered by the Office of Biotechnology Products (OBP) of the U.S. Food and Drug Administration (FDA) Office of Pharmaceutical Science. QbD examines the life cycle of a product, including its process of manufacture, discovery and development. The process was instated due to a suboptimal level of drug manufacture and the FDA's outdated biotechnology review process, which had unwanted affects on drug regulation. Such difficulties led to higher costs, which QbD is ultimately intended to address and correct. The elements of the process are evaluated, and case studies from biologics manufacturers are provided.
KW - RESEARCH
KW - Biologicals
KW - Product life cycle
KW - Product management
KW - Manufacturing processes -- Management
KW - Pharmaceutical policy
KW - Case studies
KW - Drugs -- Prices
KW - United States. Food & Drug Administration
N1 - Accession Number: 35995154; Rathore, Anurag S 1; Winkle, Helen 2; Affiliations: 1: Anurag S. Rathore is in Process Development, M/S 30-2-A, One Amgen Center Drive, Thousand Oaks, California 91320, USA. asrathore@yahoo.com; 2: Helen Winkle is in the Office of Pharmaceuticals, Center for Drug Evaluation and Research, 5600 Fishers Lane, Rockville, Maryland 20857-0001, USA.; Issue Info: Jan2009, Vol. 27 Issue 1, p26; Thesaurus Term: RESEARCH; Thesaurus Term: Biologicals; Subject Term: Product life cycle; Subject Term: Product management; Subject Term: Manufacturing processes -- Management; Subject Term: Pharmaceutical policy; Subject Term: Case studies; Subject Term: Drugs -- Prices ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 9p; Illustrations: 4 Diagrams, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1038/nbt0109-26
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gang Chen
AU - Bower, Kimberly A.
AU - Mei Xu
AU - Min Ding
AU - Xianglin Shi
AU - Zun-Ji Ke
AU - Jia Luo
T1 - Cyanidin-3-Glucoside Reverses Ethanol-induced Inhibition of Neurite Outgrowth: Role of Glycogen Synthase Kinase 3 beta.
JO - Neurotoxicity Research
JF - Neurotoxicity Research
Y1 - 2009/01//
VL - 15
IS - 1
M3 - Article
SP - 1
EP - 36
SN - 10298428
AB - Ethanol is a potent teratogen for the developing central nervous system (CNS), and fetal alcohol syndrome (FAS) is the most common nonhereditary cause of mental retardation. Ethanol disrupts neuronal differentiation and maturation. It is important to identify agents that provide neuroprotection against ethanol neurotoxicity. Using an in vitro neuronal model, mouse N2a neuroblastoma cells, we demonstrated that ethanol inhibited neurite outgrowth and the expression of neurofilament proteins. Glycogen synt hase kinase 3β (GSK3β), a multifunctional serine/threonine kinase negatively regulated neurite outgrowth of N2a cells; inhibiting GSK3β activity by retinoic acid (RA) and lithium induced neurite outgrowth, while over-expression of a consti tutively active S9A GSK3β mutant prevented neurite outgrowth. Ethanol inhibited neurite outgrowth by activating GSK3β through the dephosphorylation of GSK3β at serine 9. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family rich i n many edible berries and other pigmented fruits, enhanced neurite outgrowth by promoting p-GSK3β(Ser9). More importantly, C3G reversed ethanol-mediated activation of GSK3β and inhibition of neurite outgrowth as well as the expression of neurof ilament proteins. C3G also blocked ethanol-induced intracellular accumulation of reactive oxygen species (ROS). However, the antioxidant effect of C3G appeared minimally involved in its protection. Our study provides a potential avenue for preventing or ameliorating ethanol-induced damage to the developing CNS. [ABSTRACT FROM AUTHOR]
AB - Copyright of Neurotoxicity Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALCOHOL
KW - GLYCOGEN synthase kinase-3
KW - TERATOGENIC agents
KW - CENTRAL nervous system
KW - FETAL alcohol syndrome
KW - MENTAL disabilities
KW - MICE as laboratory animals
KW - Alcohol
KW - development
KW - differentiation
KW - fetal alcohol syndrome
KW - neuroprotection
N1 - Accession Number: 36323171; Gang Chen 1 Bower, Kimberly A. 1 Mei Xu 1 Min Ding 1,2 Xianglin Shi 3 Zun-Ji Ke 4 Jia Luo 1,4; Email Address: jialuo888@uky.edu; Affiliation: 1: Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536, U.S.A. 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, U.S.A. 3: Graduate Center for Toxicology, University of Kentucky, 232 Bosomworth, Lexington, Kentucky 40536, U.S.A. 4: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China; Source Info: 2009, Vol. 15 Issue 1, Special section p1; Subject Term: ALCOHOL; Subject Term: GLYCOGEN synthase kinase-3; Subject Term: TERATOGENIC agents; Subject Term: CENTRAL nervous system; Subject Term: FETAL alcohol syndrome; Subject Term: MENTAL disabilities; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: Alcohol; Author-Supplied Keyword: development; Author-Supplied Keyword: differentiation; Author-Supplied Keyword: fetal alcohol syndrome; Author-Supplied Keyword: neuroprotection; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 36p; Illustrations: 3 Black and White Photographs, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boctor, Sherin Y.
AU - Ferguson, Sherry A.
T1 - Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague–Dawley rats
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2009/01//
VL - 30
IS - 1
M3 - Article
SP - 151
EP - 154
SN - 0161813X
AB - Abstract: Glutamate activation of the NMDA receptor is essential for neuronal differentiation, migration, and survival. Treatment with NMDA receptor antagonists, such as ketamine (KET) or phencyclidine (PCP), can trigger apoptosis in neonatal rats. However, l-carnitine (LC) treatment appears to prevent glutamate-induced toxicity in the developing CNS. Previously, we described altered preweaning behaviors (i.e., abnormal home cage, slant board and forelimb hang behaviors) resulting from neonatal PCP and KET treatment. Those adverse effects of KET were somewhat ameliorated by LC [Boctor SY, Wang C, Ferguson SA. Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague–Dawley rats. Toxicol Sci 2008;106:172–9]. Here, a portion of those subjects were evaluated for prepulse inhibition (PPI) of the acoustic startle response at postnatal day (PND) 25 since previous reports described PCP-induced effects on this response. Rats were subcutaneously treated with: saline; 10mg/kg PCP (1×/day) on PNDs 7, 9 and 11; 20mg/kg KET (6 injections every 2h on PND 7); or a similar regimen of ketamine and 250mg/kg LC on PND 7, with a single injection of 250mg/kg LC on PNDs 8–11 (KLC). Male and female rats were assessed using a standard PPI paradigm with prepulses of 68, 78 and 82dB. Body weight was decreased 17–21% and whole brain weight was decreased 10% in PCP-treated rats. Specifically, cerebellar weight was significantly less in PCP-treated rats relative to control. Despite the magnitude of those PCP-induced changes, startle response in normal pulse only trials and percent of PPI in PCP-, KET-, and KLC-treated groups were comparable to controls. Average latency to maximum startle was 2.6ms less in females than males (p <0.007); there were no other significant sex effects. The lack of neonatal PCP treatment on later PPI is similar to that reported by Rasmussen et al. [Rasmussen BA, O’Neil J, Manaye KF, Perry DC, Tizabi Y. Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology (Berl) 2007; 190: 43–9.], and indicates that neonatal PCP-induced effects on PPI [Wang C, McInnis J, Ross-Sanchez M, Shinnick-Gallagher P, Wiley JL, Johnson KM. Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. Neuroscience 2001; 107: 535–50.] appear difficult to replicate. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANESTHETICS -- Physiological effect
KW - GLUTAMIC acid
KW - KETAMINE
KW - PHENCYCLIDINE
KW - SPRAGUE Dawley rats
KW - BODY weight
KW - METHYL aspartate
KW - Body weight
KW - Ketamine
KW - Phencyclidine
KW - Prepulse inhibition
KW - Sensorimotor gating
N1 - Accession Number: 36189873; Boctor, Sherin Y. 1,2; Email Address: Sherin.Boctor@fda.hhs.gov Ferguson, Sherry A. 1,2; Email Address: Sherry.Ferguson@fda.hhs.gov; Affiliation: 1: Department of Interdisciplinary Biomedical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States 2: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States; Source Info: Jan2009, Vol. 30 Issue 1, p151; Subject Term: ANESTHETICS -- Physiological effect; Subject Term: GLUTAMIC acid; Subject Term: KETAMINE; Subject Term: PHENCYCLIDINE; Subject Term: SPRAGUE Dawley rats; Subject Term: BODY weight; Subject Term: METHYL aspartate; Author-Supplied Keyword: Body weight; Author-Supplied Keyword: Ketamine; Author-Supplied Keyword: Phencyclidine; Author-Supplied Keyword: Prepulse inhibition; Author-Supplied Keyword: Sensorimotor gating; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neuro.2008.10.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weld, Konstantine Keian
AU - Garmon Bibb, Sandra C.
T1 - Concept Analysis: Malpractice and Modern-Day Nursing Practice.
JO - Nursing Forum
JF - Nursing Forum
Y1 - 2009/01//Jan-Mar2009
VL - 44
IS - 1
M3 - Article
SP - 2
EP - 10
PB - Wiley-Blackwell
SN - 00296473
AB - TOPIC. The concept of malpractice can mean different things depending upon the context in which the term is used. This can lead to confusion about the standard of care required for nurses engaged in modern-day nursing practice. PURPOSE. This paper examines the attributes and characteristics of the concept of malpractice using Walker and Avant's (2005) eight-step methodology. SOURCES OF INFORMATION. CINAHL, PubMed, and PsychINFO. CONCLUSIONS. Exposure to malpractice liability is an unfortunate consequence of modern-day nursing practice. An understanding of malpractice will assist nurses in identifying situations that may expose them to legal liability and hopefully lead to improved patient care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nursing Forum is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MALPRACTICE
KW - NURSING -- Practice
KW - MEDICINE -- Practice
KW - CARE of people
KW - NURSES
N1 - Accession Number: 36335802; Weld, Konstantine Keian 1; Email Address: keian.weld@hhs.gov Garmon Bibb, Sandra C. 2; Affiliation: 1: Commissioned Corps of the U.S. Public Health Service 2: Associate Professor and Chair, Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, MD; Source Info: Jan-Mar2009, Vol. 44 Issue 1, p2; Subject Term: MALPRACTICE; Subject Term: NURSING -- Practice; Subject Term: MEDICINE -- Practice; Subject Term: CARE of people; Subject Term: NURSES; Number of Pages: 9p; Document Type: Article
L3 - 10.1111/j.1744-6198.2009.00121.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wilder, Kathleen J.
AU - Guise, Jeane-Marie
AU - Perrin, Nancy A.
AU - Hanson, Ginger C.
AU - Hernandez, Rebecca
AU - Glass, Nancy
T1 - Knowledge, Awareness, Perceptions, and Use of Emergency Contraceptives among Survivors of Intimate Partner Violence.
JO - Obstetrics & Gynecology International
JF - Obstetrics & Gynecology International
Y1 - 2009/01//
VL - 2009
M3 - Article
SP - 1
EP - 6
SN - 16879589
AB - The study examines emergency contraception (EC) knowledge, awareness, perceptions, and prior use and identifies predictors of EC use among a sample of survivors of intimate partner violence (IPV). The majority (66.2%) of 154 survivors at risk of pregnancy reported EC awareness, only 15.3% reported prior EC use. Logistic regression identified perceived abusive intimate partner approval (OR = 2.25; 95% CI = 1.15-4.41) and lack of moral/religious objections (OR = 12.83; 95% CI = 5.48-30.03) as the strongest predictors of EC use. Health care provider interventions acknowledging barriers to EC use, such as partner approval, and education that improves awareness of and knowledge about EC, may have the impact of empowering survivors in their reproductive choices, reducing unwanted pregnancies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Obstetrics & Gynecology International is the property of Hindawi Publishing Corporation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORAL contraceptives
KW - INTIMATE partner violence
KW - CONTRACEPTION
KW - BIRTH control
KW - UNWANTED pregnancy
KW - PREVENTION
KW - WOMEN -- Health
KW - WOMEN -- Sexual behavior
KW - ABORTION
KW - NORTH America
N1 - Accession Number: 53492594; Wilder, Kathleen J. 1 Guise, Jeane-Marie 2 Perrin, Nancy A. 3; Email Address: nancy.perrin@kpchr.org Hanson, Ginger C. 3 Hernandez, Rebecca 4 Glass, Nancy 5; Affiliation: 1: Department of OB/GYN, Northern Navajo Medical Center, Indian Health Service, Shiprock, NM 87420, USA 2: Department of OB/GYN, Oregon Health and Sciences University School of Medicine, Portland, OR 97239, USA 3: Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, USA 4: Center for Intercultural Teaching and Learning, School of Nursing, Goshen College 1700 S. Main Street Goshen, IN 46526, USA 5: Johns Hopkins Center for Global Health, Johns Hopkins University School of Nursing, 525 North Wolfe Street, Rm 433, Baltimore, MD 21205, USA; Source Info: 2009, Vol. 2009, p1; Subject Term: ORAL contraceptives; Subject Term: INTIMATE partner violence; Subject Term: CONTRACEPTION; Subject Term: BIRTH control; Subject Term: UNWANTED pregnancy; Subject Term: PREVENTION; Subject Term: WOMEN -- Health; Subject Term: WOMEN -- Sexual behavior; Subject Term: ABORTION; Subject Term: NORTH America; NAICS/Industry Codes: 621410 Family Planning Centers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1155/2009/625465
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yong, L. C.
AU - A. J. Sigurdson
AU - E. M. Ward
AU - M. A. Waters
AU - E. A. Whelan
AU - M. R. Petersen
AU - P. Bhatti
AU - M. J. Ramsey
AU - E. Ron
AU - J. D. Tucker
T1 - Increased frequency of chromosome translocations in airline pilots with long-term flying experience.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2009/01//
VL - 66
IS - 1
M3 - Article
SP - 56
EP - 62
SN - 13510711
AB - Background: Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. Airline pilots are exposed to cosmic ionising radiation, but few flight crew studies have examined translocations in relation to flight experience. Methods: We determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects (mean age 47 and 46 years, respectively). Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Negative binomial regression models were used to assess the relationship between translocation frequency and exposure status and flight years, adjusting for age, diagnostic x ray procedures, and military flying. Results: There was no significant difference in the adjusted mean translocation frequency of pilots and comparison subjects (0.37 (SE 0.04) vs 0.38 (SE 0.06) translocations/100 CE, respectively). However, among pilots, the adjusted translocation frequency was significantly associated with flight years (p = 0.01) with rate ratios of 1.06 (95% CI 1.01 to 1.11) and 1.81 (95% CI 1.16 to 2.82) for a 1-and 10-year incremental increase in flight years, respectively. The adjusted rate ratio for pilots in the highest compared to the lowest quartile of flight years was 2.59 (95% CI 1.26 to 5.33). Conclusions: Our data suggests that pilots with long-term flying experience may be exposed to biologically significant doses of ionising radiation. Epidemiological studies with longer follow-up of larger cohorts of pilots with a wide range of radiation exposure levels are needed to clarify the relationship between cosmic radiation exposure and cancer risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ionizing radiation
KW - DISEASES
KW - Genetics
KW - Research
KW - Air pilots
KW - Chromosomes
KW - Translocation (Genetics)
KW - Airline industry employees
KW - Cancer
KW - Leucocytes
N1 - Accession Number: 36119401; Yong, L. C. 1; Email Address: LAY7@CDC.GOV; A. J. Sigurdson 2; E. M. Ward 3; M. A. Waters 1; E. A. Whelan 1; M. R. Petersen 1; P. Bhatti 2; M. J. Ramsey 4; E. Ron 2; J. D. Tucker 5; Affiliations: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.; 2: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.; 3: Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA.; 4: Lawrence Livermore National Laboratory, Livermore, California, USA.; 5: Department of Biological Sciences, Wayne State University, Detroit, Michigan, USA.; Issue Info: Jan2009, Vol. 66 Issue 1, p56; Thesaurus Term: Ionizing radiation; Thesaurus Term: DISEASES; Thesaurus Term: Genetics; Thesaurus Term: Research; Subject Term: Air pilots; Subject Term: Chromosomes; Subject Term: Translocation (Genetics); Subject Term: Airline industry employees; Subject Term: Cancer; Subject Term: Leucocytes; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1136/oem.2008.038901
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105608779
T1 - Increased frequency of chromosome translocations in airline pilots with long-term flying experience.
AU - Yong LC
AU - Sigurdson AJ
AU - Ward EM
AU - Waters MA
AU - Whelan EA
AU - Petersen MR
AU - Bhatti P
AU - Ramsey MJ
AU - Ron E
AU - Tucker JD
AU - Yong, L C
AU - Sigurdson, A J
AU - Ward, E M
AU - Waters, M A
AU - Whelan, E A
AU - Petersen, M R
AU - Bhatti, P
AU - Ramsey, M J
AU - Ron, E
AU - Tucker, J D
Y1 - 2009/01//
N1 - Accession Number: 105608779. Language: English. Entry Date: 20090220. Revision Date: 20161119. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Z01 CP010133-12//Intramural NIH HHS/United States. NLM UID: 9422759.
KW - Aerospace Medicine
KW - Aircraft
KW - Chromosome Disorders
KW - Occupational Diseases -- Epidemiology
KW - Radiation, Ionizing -- Adverse Effects
KW - Adult
KW - In Situ Hybridization, Fluorescence
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Etiology
KW - Occupational Diseases
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Exposure -- Analysis
KW - Radiation Dosage
KW - Time Factors
SP - 56
EP - 62
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
JA - OCCUP ENVIRON MED
VL - 66
IS - 1
PB - BMJ Publishing Group
AB - Background: Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. Airline pilots are exposed to cosmic ionising radiation, but few flight crew studies have examined translocations in relation to flight experience.Methods: We determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects (mean age 47 and 46 years, respectively). Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Negative binomial regression models were used to assess the relationship between translocation frequency and exposure status and flight years, adjusting for age, diagnostic x ray procedures, and military flying.Results: There was no significant difference in the adjusted mean translocation frequency of pilots and comparison subjects (0.37 (SE 0.04) vs 0.38 (SE 0.06) translocations/100 CE, respectively). However, among pilots, the adjusted translocation frequency was significantly associated with flight years (p = 0.01) with rate ratios of 1.06 (95% CI 1.01 to 1.11) and 1.81 (95% CI 1.16 to 2.82) for a 1- and 10-year incremental increase in flight years, respectively. The adjusted rate ratio for pilots in the highest compared to the lowest quartile of flight years was 2.59 (95% CI 1.26 to 5.33).Conclusions: Our data suggests that pilots with long-term flying experience may be exposed to biologically significant doses of ionising radiation. Epidemiological studies with longer follow-up of larger cohorts of pilots with a wide range of radiation exposure levels are needed to clarify the relationship between cosmic radiation exposure and cancer risk.
SN - 1351-0711
AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA
U2 - PMID: 19074211.
DO - 10.1136/oem.2008.038901
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105451397
T1 - Sorafenib for the treatment of unresectable hepatocellular carcinoma.
AU - Kane RC
AU - Farrell AT
AU - Madabushi R
AU - Booth B
AU - Chattopadhyay S
AU - Sridhara R
AU - Justice R
AU - Pazdur R
Y1 - 2009/01//
N1 - Accession Number: 105451397. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Commentary: Abou-Alfa GK. Commentary: sorafenib -- the end of a long journey in search of systemic therapy for hepatocellular carcinoma, or the beginning? (ONCOLOGIST) Jan2009; 14 (1): 92-94. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Oncologic Care. NLM UID: 9607837.
KW - Antineoplastic Agents -- Therapeutic Use
KW - Carcinoma, Hepatocellular -- Drug Therapy
KW - Enzyme Inhibitors -- Therapeutic Use
KW - Phosphotransferases -- Antagonists and Inhibitors
KW - Sorafenib
KW - Antineoplastic Agents -- Adverse Effects
KW - Clinical Trials
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Enzyme Inhibitors -- Adverse Effects
KW - Kaplan-Meier Estimator
KW - Log-Rank Test
KW - Placebos
KW - Survival
KW - United States Food and Drug Administration
KW - Human
SP - 95
EP - 100
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 14
IS - 1
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - PURPOSE: To describe the U.S. Food and Drug Administration (FDA) review and approval of sorafenib (Nexavar; Bayer Pharmaceuticals Corp., Montville, NJ, and Onyx Pharmaceuticals Corp., Emeryville, CA), an oral kinase inhibitor, for the treatment of patients with unresectable hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN: The FDA independently analyzed an international, double-blind, placebo-controlled trial comparing the effect of best supportive care plus sorafenib or matching placebo on overall survival. Eligible patients had unresectable, biopsy-proven HCC and had not received prior systemic therapy. RESULTS: Among the 602 randomized patients (placebo, 303; sorafenib, 299), baseline characteristics were well balanced, and 97% were Child-Pugh score A. HCC was 'advanced' in 70% overall, as defined by extrahepatic metastases or by tumor radiographically visible in venous structures outside the liver. Underlying liver diseases included hepatitis B (18%), hepatitis C (28%), and alcohol-related (26%). The trial was stopped following a prespecified second interim analysis showing a statistically significant survival advantage for sorafenib [median, 10.7 vs 7.9 months; hazard ratio, 0.69 (95% confidence interval, (0.55, 0.87)), p = 0.00058]. Adverse events in sorafenib-treated patients included diarrhea in 55% (grade 3, 10%), hand-foot syndrome in 21% (grade 3, 8%), rash in 19% (grade 3, 1%), and cardiac ischemia or infarction in 2.7% (versus 1.3% for placebo). On sorafenib, treatment-emergent hypertension occurred in 9% of patients (placebo, 4%) and was grade 3 in 4% (placebo, 1%); elevated serum lipase occurred in 40% (placebo, 37%); hypophosphatemia occurred in 35% (placebo, 11%). CONCLUSIONS: Sorafenib is the first systemic therapy to demonstrate a survival benefit in a randomized trial for unresectable HCC and has received FDA approval for this indication.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0004, USA. robert.kane@fda.hhs.gov
U2 - PMID: 19144678.
DO - 10.1634/theoncologist.2008-0185
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Donaldson, Ken
AU - Borm, Paul J. A.
AU - Castranova, Vincent
AU - Gulumian, Mary
T1 - The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2009/01//
VL - 6
M3 - Article
SP - 1
EP - 8
PB - BioMed Central
SN - 17438977
AB - In vitro studies with particles are a major staple of particle toxicology, generally used to investigate mechanisms and better understand the molecular events underlying cellular effects. However, there is ethical and financial pressure in nanotoxicology, the new sub-specialty of particle toxicology, to avoid using animals. Therefore an increasing amount of studies are being published using in vitro approaches and such studies require careful interpretation. We point out here that 3 different conventional pathogenic particle types, PM10, asbestos and quartz, which cause diverse pathological effects, have been reported to cause very similar oxidative stress effects in cells in culture. We discuss the likely explanation and implications of this apparent paradox, and its relevance for testing in nanotoxicology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oxidation-reduction reaction
KW - Toxicology
KW - Pharmacology
KW - Oxidative stress
KW - Nanoparticles
N1 - Accession Number: 42094134; Donaldson, Ken 1; Email Address: ken.donaldson@ed.ac.uk; Borm, Paul J. A. 2; Email Address: p.borm@hszuyd.nl; Castranova, Vincent 3; Email Address: vic1@cdc.gov; Gulumian, Mary 4; Email Address: Mary.Gulumian@nioh.nhls.ac.za; Affiliations: 1: MRC/University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.; 2: Zuyd University, Nieuw Eyckholt 300, Heerlen, Limburg, 6400 AN, The Netherlands.; 3: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia, USA.; 4: National Institute for Occupational Health, P O Box 4788, Johannesburg 2000, University of the Witwatersrand, Witwatersrand, South Africa.; Issue Info: 2009, Vol. 6, p1; Thesaurus Term: Oxidation-reduction reaction; Thesaurus Term: Toxicology; Thesaurus Term: Pharmacology; Subject Term: Oxidative stress; Subject Term: Nanoparticles; Number of Pages: 8p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1186/1743-8977-6-13
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sager, Tina M.
AU - Castranova, Vincent
T1 - Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide.
JO - Particle & Fibre Toxicology
JF - Particle & Fibre Toxicology
Y1 - 2009/01//
VL - 6
M3 - Article
SP - 1
EP - 12
PB - BioMed Central
SN - 17438977
AB - Background: Nanoparticles are characterized by having a high surface area per mass. Particulate surface area has been reported to play an important role in determining the biological activity of nanoparticles. However, recent reports have questioned this relationship. This study was conducted to determine whether mass of particles or surface area of particles is the more appropriate dose metric for pulmonary toxicity studies. In this study, rats were exposed by intratracheal instillation to various doses of ultrafine and fine carbon black. At 1, 7, or 42 days postexposure, inflammatory and cytotoxic potential of each particle type was compared on both a mass dosage (mg/rat) as well as an equal surface area dosage (cm2 of particles per cm2 of alveolar epithelium). In an additional study, the pulmonary responses to instillation of ultrafine carbon black were compared to equivalent particle surface area doses of ultrafine titanium dioxide. Results: Ultrafine carbon black particles caused a dose dependent but transient inflammatory and cytotoxic response. On a mass basis, these responses were significantly (65 fold) greater than those for fine sized carbon black. However, when doses were equalized based on surface area of particles given, the ultrafine carbon black particles were only slightly (non-significantly) more inflammogenic and cytotoxic compared to the fine sized carbon black. At one day post-exposure, inflammatory potencies of the ultrafine carbon black and ultrafine titanium dioxide particles were similar. However, while the pulmonary reaction to ultrafine carbon black resolved with time, the inflammatory effects of ultrafine titanium dioxide were more persistent over a 42 day postexposure period. Conclusion: These results indicate that for low toxicity low solubility materials, surface area of particles administered rather than mass burden of particles may be a more appropriate dose metric for pulmonary toxicity studies. In addition, ultrafine titanium dioxide appears to be more bioactive than ultrafine carbon black on an equivalent surface area of particles delivered basis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Particle & Fibre Toxicology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxicity testing
KW - Lung diseases
KW - Titanium dioxide
KW - Nanoparticles
KW - Epithelium
N1 - Accession Number: 42094136; Sager, Tina M. 1,2; Email Address: sst2@cdc.gov; Castranova, Vincent 1; Email Address: vic1@cdc.gov; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; 2: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.; Issue Info: 2009, Vol. 6, p1; Thesaurus Term: Toxicity testing; Subject Term: Lung diseases; Subject Term: Titanium dioxide; Subject Term: Nanoparticles; Subject Term: Epithelium; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 12p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1186/1743-8977-6-15
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=42094136&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Grosse, Scott D.
AU - Schechter, Michael S.
AU - Kulkarni, Roshni
AU - Lloyd-Puryear, Michele A.
AU - Strickland, Bonnie
AU - Trevathan, Edwin
T1 - Models of Comprehensive Multidisciplinary Care for Individuals in the United States With Genetic Disorders.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/01//
VL - 123
IS - 1
M3 - Article
SP - 407
EP - 412
SN - 00314005
AB - Approaches to providing comprehensive coordinated care for individuals with complex diseases include the medical home approach, the chronic care model in primary care, and disease-specific, multidisciplinary specialty clinics. There is uneven availability and utilization of multidisciplinary specialty clinics for different genetic diseases. For 2 disorders (ie, hemophilia and cystic fibrosis), effective national networks of specialty clinics exist and reach large proportions of the target populations. For other disorders, notably, sickle cell disease, fewer such centers are available, centers are less likely to be networked, and centers are used less widely. Models of comanagement are essential for promoting ongoing communication and coordination between primary care and subspecialty services, particularly during the transition from pediatric care to adult care. Evaluation of the effectiveness of different models in improving outcomes for individuals with genetic diseases is essential. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC disorders
KW - PATIENTS
KW - HOME care services
KW - PRIMARY care (Medicine)
KW - HEALTH services administration
KW - UNITED States
KW - care coordination
KW - genetic services
KW - health care disparities
KW - health care utilization
N1 - Accession Number: 36094250; Grosse, Scott D. 1 Schechter, Michael S. 2 Kulkarni, Roshni 1 Lloyd-Puryear, Michele A. 3 Strickland, Bonnie 3 Trevathan, Edwin 1; Email Address: net1@cdc.gov; Affiliation: 1: NationaI Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Department of Pediatrics, Emory University, Atlanta, Georgia, USA 3: Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Maryland, USA; Source Info: Jan2009, Vol. 123 Issue 1, p407; Subject Term: GENETIC disorders; Subject Term: PATIENTS; Subject Term: HOME care services; Subject Term: PRIMARY care (Medicine); Subject Term: HEALTH services administration; Subject Term: UNITED States; Author-Supplied Keyword: care coordination; Author-Supplied Keyword: genetic services; Author-Supplied Keyword: health care disparities; Author-Supplied Keyword: health care utilization; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621390 Offices of all other health practitioners; NAICS/Industry Codes: 624120 Services for the Elderly and Persons with Disabilities; NAICS/Industry Codes: 621610 Home Health Care Services; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; Number of Pages: 6p; Document Type: Article
L3 - 10.1542/peds.2007-2875
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36094250&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johann-Liang, Rosemary
AU - Wyeth, Jo
AU - Chen, Min
AU - Cope, Judith U.
T1 - Pediatric drug surveillance and the food and drug administration's adverse event reporting system: an overview of reports, 2003-2007.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/01//
VL - 18
IS - 1
M3 - Article
SP - 24
EP - 27
SN - 10538569
AB - Purpose Our objective was to examine the numbers and characteristics of US pediatric adverse events (AEs) reported to the Food and Drug Administration (FDA)'s adverse event reporting system (AERS) for 5 years following implementation of the Best Pharmaceuticals for Children Act (BPCA) in 2002. Methods We analyzed reports in AERS received by FDA from January 1, 2003 to January 1, 2008 for overall numbers, age, gender, and seriousness of outcome in children and adults. Pediatric and adult age groups (<2, 2-10, 11-17, 18-50, and >50 years of age) were further evaluated for most frequently reported suspect drug classes and AEs. Results Seventy-two percent of 815 267 crude count reports had specified age information. Six percent of the total reports with age information reported age <18 years. Numbers of AEs being reported for children have remained steady, while those for adults have increased. The proportion of serious AEs reported was similar for pediatrics as compared to adults. Frequently reported suspect drug classes noted in pediatric age groups that were not observed in adults included anticonvulsants, attention deficit hyperactivity disorder (ADHD), anti-acne, and respiratory medications. Conclusions This overview highlights the need for strengthening the passive drug surveillance system from a pediatric perspective, as well as investing in more active surveillance systems. Drug safety initiatives to better capture risk information in order to balance the risk/benefit of drug use in children. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707273; Johann-Liang, Rosemary 1; Wyeth, Jo 2; Chen, Min 2; Cope, Judith U. 3; Affiliations: 1: Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD, USA; 2: Division of Adverse Event Analysis, Office of Surveillance and Epidemiology, United States Food and Drug Administration, Silver Spring, MD, USA; 3: Office of Pediatric Therapeutics, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Jan2009, Vol. 18 Issue 1, p24; Number of Pages: 4p; Document Type: Article
L3 - 10.1002/pds.1679
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Porter-Jones, G.
AU - Williams, S.
AU - Powell, C.
AU - Pusey, L.
AU - Roberts, R. J.
T1 - Impact of a novel way to communicate information about MMR on uptake of MMR vaccine: A randomized controlled trial.
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
Y1 - 2009/01//
VL - 123
IS - 1
M3 - Article
SP - 78
EP - 80
SN - 00333506
AB - The article discusses a study on impact of the provision of teddy bears wearing T-shirts showing a web site address and telephone number offering information about measles, mumps and rubella (MMR) on the uptake of the MMR vaccine in Flintshire, Wales. Under the study, 974 children were either given normal management alone or normal management with the addition of such a teddy bear. Results indicate no significant difference in MMR vaccine uptake from both groups. It examines factors that may have contributed to such outcome which include Internet access.
KW - TEDDY bears
KW - HEALTH education
KW - COMMUNICATION in medicine
KW - MMR vaccine
KW - VACCINATION
KW - HEALTH behavior
KW - FLINTSHIRE (Wales)
KW - WALES
N1 - Accession Number: 36979842; Porter-Jones, G. 1; Email Address: gary.porter-jones@nphs.wales.nhs.uk Williams, S. 1 Powell, C. 1 Pusey, L. 2 Roberts, R. J. 3; Affiliation: 1: Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold CH7 1PZ, UK 2: Flintshire Local Health Board, Preswylfa, Hendy Road, Mold CH7 1PZ, UK 3: Vaccine Preventable Disease Programme, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK; Source Info: Jan2009, Vol. 123 Issue 1, p78; Subject Term: TEDDY bears; Subject Term: HEALTH education; Subject Term: COMMUNICATION in medicine; Subject Term: MMR vaccine; Subject Term: VACCINATION; Subject Term: HEALTH behavior; Subject Term: FLINTSHIRE (Wales); Subject Term: WALES; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Illustrations: 1 Black and White Photograph; Document Type: Article
L3 - 10.1016/j.puhe.2008.10.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36979842&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105641651
T1 - Impact of a novel way to communicate information about MMR on uptake of MMR vaccine: A randomized controlled trial.
AU - Porter-Jones G
AU - Williams S
AU - Powell C
AU - Pusey L
AU - Roberts RJ
Y1 - 2009/01//
N1 - Accession Number: 105641651. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; research; randomized controlled trial. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 0376507.
KW - Communication
KW - Immunization Programs -- Utilization
KW - Measles-Mumps-Rubella Vaccine -- Therapeutic Use
KW - Randomized Controlled Trials
KW - Female
KW - Infant
KW - Male
KW - Measles -- Prevention and Control
KW - Mumps -- Prevention and Control
KW - Patient Compliance
KW - Rubella -- Prevention and Control
KW - Wales
KW - Human
SP - 78
EP - 80
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 123
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold CH7 1PZ, UK.
U2 - PMID: 19081119.
DO - 10.1016/j.puhe.2008.10.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105641651&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105641674
T1 - Transport and health - a five-country perspective.
AU - Coyle E
AU - Huws D
AU - Monaghan S
AU - Roddy G
AU - Seery B
AU - Staats P
AU - Thunhurst C
AU - Walker P
AU - Fleming P
Y1 - 2009/01//
N1 - Accession Number: 105641674. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 0376507.
KW - Public Health
KW - Transportation
KW - Accidents, Traffic -- Prevention and Control
KW - Accidents, Traffic
KW - Great Britain
KW - Health Status
KW - Policy Making
SP - e21
EP - 3
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 123
IS - 1
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Public Health Service and Bridgend Local Health Board.
U2 - PMID: 19135694.
DO - 10.1016/j.puhe.2008.10.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105641674&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hanibali, Ahrnad Shariff
AU - Ng, Kwan-Hoong
AU - Abdullah, Basri Johan Jeet
AU - Wang, Hwee-Beng
AU - Jamal, Noriah
AU - Spelic, David C.
AU - SuIeiinan, Orhan H.
T1 - ENTRANCE SURFACE DOSE AND IMAGE QUALITY: COMPARISON OF ADULT CHEST AND ABDOMINAL X-RAY EXAMINATIONS IN GENERAL PRACTITIONER CLINICS, PUBLIC AND PRIVATE HOSPITALS IN MALAYSIA.
JO - Radiation Protection Dosimetry
JF - Radiation Protection Dosimetry
Y1 - 2009/01//
VL - 133
IS - 1
M3 - Article
SP - 25
EP - 34
SN - 01448420
AB - This study was undertaken to compare the entrance surface dose (ESD) and image quality of adult chest and abdominal X-ray examinations conducted at general practitioner (GP) clinics, and public and private hospitals in Malaysia. The surveyed facilities were randomly selected within a given category (28 GP clinics, 20 public hospitals and 15 private hospitals). Only departmental X-ray units were involved in the survey Chest examinations were done at all facilities, while only hospitals per- formed abdominal examinations. This study used the x-ray attenuation phantoms and protocols developed for the Nationwide Evaluation of X-rat' Trends (NEXT) survey program in the United States. The ESD was calculated from measurements of exposure and clinical geometry An image quality test tool was used to evaluate the low-contrast detectability and high-contrast detail performance under typical clinical conditions. The median ESD value for the adult chest X-ray examination was the highest (0.25 mGy) at GP clinics, followed by private hospitals (0.22 mGy) and public hospitals (0.17 mGy). The median ESD for the adult abdominal X-ray examination at public hospitals (3.35 mGy) was higher than that for private hospitals (2.81 mGy). Results of image quality assessment for the chest X-ray examination show that all facility types have a similar median spatial resolution and low-contrast detectability. For the abdominal X-ray examination, public hospitals have a similar median spatial resolution but larger low-contrast detectability compared with private hospitals. The results of this survey clearly show that there is room for further improvement in performing chest and abdominal X-ray examinations in Malaysia. [ABSTRACT FROM AUTHOR]
AB - Copyright of Radiation Protection Dosimetry is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Radiation -- Dosage
KW - Medical radiography -- Image quality
KW - Chest (Anatomy) -- Examination
KW - Abdomen -- Examination
KW - X-rays
KW - Clinics
KW - Hospitals
KW - Malaysia
N1 - Accession Number: 43892808; Hanibali, Ahrnad Shariff 1; Ng, Kwan-Hoong 2; Email Address: ngkh@um.edu.my; Abdullah, Basri Johan Jeet 2; Wang, Hwee-Beng 1; Jamal, Noriah 3; Spelic, David C. 4; SuIeiinan, Orhan H. 4; Affiliations: 1: Engineering Services Division, Ministry of Health Malaysia, Level 25, Block E6, Parcel I, Federal Government Administration Centre, 62590 Putrajaya, Malaysia; 2: Department of Biomedical Imaging, University of Malaya, 50603 Kuala Lumpur, Malaysia; 3: Medical Technology Division, Malaysian Nuclear Agency, 43000 Kajang, Malaysia; 4: Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA; Issue Info: 2009, Vol. 133 Issue 1, p25; Subject Term: Radiation -- Dosage; Subject Term: Medical radiography -- Image quality; Subject Term: Chest (Anatomy) -- Examination; Subject Term: Abdomen -- Examination; Subject Term: X-rays; Subject Term: Clinics; Subject Term: Hospitals; Subject: Malaysia; NAICS/Industry Codes: 621494 Community health centres; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 621499 All other out-patient care centres; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 10p; Illustrations: 5 Black and White Photographs, 9 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/rpd/ncp007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Anderson, Nathan
T1 - Risk-Based Process Development.
JO - Resource: Engineering & Technology for a Sustainable World
JF - Resource: Engineering & Technology for a Sustainable World
Y1 - 2009/01//Jan/Feb2009
VL - 16
IS - 1
M3 - Article
SP - 12
EP - 13
SN - 10763333
AB - The article offers information on the Food Safety Objective (FSO) approach. It states that increased concern over microbiological food safety in consideration of public health and international food trade has led a change in how microbial risks are evaluated and controlled. Relative to this, it forwards that FSO is an output-oriented metric that designates the maximum level of hazard endured in a food at the end of the food supply chain. Moreover, FSOs are used to derive performance criteria at control measures upstream in the food supply chain to attain a target endpoint level.
KW - Food -- Safety measures
KW - Food industry
KW - Public health
KW - Food science
KW - Food handling
KW - Food supply
KW - Food consumption
KW - Agriculture
KW - Produce trade
N1 - Accession Number: 36312291; Anderson, Nathan 1; Email Address: nathan.anderson@fda.hhs.gov; Affiliations: 1: U.S. Food and Drug Administration, National Center for Food Safety and Technology Summit Argo, III., USA; Issue Info: Jan/Feb2009, Vol. 16 Issue 1, p12; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food industry; Thesaurus Term: Public health; Thesaurus Term: Food science; Thesaurus Term: Food handling; Thesaurus Term: Food supply; Thesaurus Term: Food consumption; Thesaurus Term: Agriculture; Subject Term: Produce trade; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 424480 Fresh Fruit and Vegetable Merchant Wholesalers; NAICS/Industry Codes: 413150 Fresh fruit and vegetable merchant wholesalers; NAICS/Industry Codes: 445230 Fruit and Vegetable Markets; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - CHAP
ID - 2009-03848-004
AN - 2009-03848-004
AU - Doré, Peter
AU - Stiffman, Arlene Rubin
ED - Stiffman, Arlene Rubin
ED - Stiffman, Arlene Rubin, (Ed)
T1 - Managing the data from survey development through archiving.
T2 - The field research survival guide.
Y1 - 2009///
SP - 59
EP - 81
CY - New York, NY, US
PB - Oxford University Press
SN - 978-0-19-532552-2
N1 - Accession Number: 2009-03848-004. Partial author list: First Author & Affiliation: Doré, Peter; Data Management Unit, Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20090511. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. ISBN: 978-0-19-532552-2, Paperback. Language: English. Major Descriptor: Cost Containment; Data Collection; Psychometrics; Statistical Analysis; Data Mining. Minor Descriptor: Experimenters. Classification: Research Methods & Experimental Design (2260). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 23.
AB - The goal for any researcher is to choose and use established, highly valid instruments and to use them to collect data without adding any errors due to mistypes, misunderstandings, omissions, or commissions. Yet at the same time, the field researcher must contain costs and time while dealing with the skill level constraints of responders, interviewers, and data entry personnel. This chapter discusses the issues that researchers confront in meeting these constraints and illustrates each with specific examples of successes and failures. The issues we cover include adapting instruments and questions, selecting data collection venues (computer or paper and pencil), formatting instruments to maximize ease of managing the data through data entry, data cleaning, and archiving. We intentionally do not talk about content of the survey instrument nor give formal theory or advice on psychometric properties or item response theory. Our goal is to share our experiences in trying to keep costs contained while maximizing the smooth flow from data collection through cleaning and analyses to final data archiving. Clean, clear, accurate data mean everything to the success of research. Instrument selection, survey format, data entry, data cleaning, and data preservation cannot be overlooked without dire consequences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - instruments
KW - data collection
KW - data analysis
KW - researchers
KW - archiving
KW - containing costs
KW - 2009
KW - Cost Containment
KW - Data Collection
KW - Psychometrics
KW - Statistical Analysis
KW - Data Mining
KW - Experimenters
KW - 2009
DO - 10.1093/acprof:oso/9780195325522.003.0004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03848-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Martínez-Zapata, Ma José
AU - Martí-Carvajal, Arturo
AU - Solà, Ivan
AU - Bolibar, Ignasi
AU - Expósito, José Ángel
AU - Rodriguez, Luciano
AU - García, Joan
T1 - Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review.
JO - Transfusion
JF - Transfusion
Y1 - 2009/01//
VL - 49
IS - 1
M3 - Article
SP - 44
EP - 56
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Autologous plasma rich in platelets (PRP) is a derived blood product whose application in clinical practice is growing. A systematic review was conducted to evaluate its efficacy and safety. STUDY DESIGN AND METHODS: A search was performed in electronic databases. Randomized controlled clinical trials (RCTs) in adult patients were included and assessed for methodologic quality. The main outcomes were “tissue regeneration” and “safety.” Relative risks (RRs) and standardized mean differences (SMDs) were calculated to show pooled estimates for these outcomes. When the results heterogeneity was more than 50 percent, a sensitivity analysis was performed. RESULTS: Twenty RCTs were included (11 of oral and maxillofacial surgery, 7 of chronic skin ulcers, and 2 of surgery wounds). Four RCTs evaluated the depth reduction in gingival recession in chronic periodontitis; the SMD was 0.54 (95% confidence interval [CI], 0.16 to 0.92) mm, favorable to PRP. Three RCTs evaluated the clinical attachment level in chronic periodontitis; the SMD was 0.33 (95% CI, −0.71 to 1.37) mm. Six RCTs assessed the complete skin epithelialization in wound ulcers; the RR was 1.40 (95% CI, 0.85 to 2.31). Only 6 RCTs reported adverse effects without differences between groups. CONCLUSIONS: PRP improves the gingival recession but not the clinical attachment level in chronic periodontitis. In the complete healing process of chronic skin ulcers, the results are inconclusive. There are little data about PRP safety. There are several methodologic limitations and, consequently, future research should focus on strong and well-designed RCTs that assess the efficacy and safety of PRP. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD plasma
KW - BLOOD platelets
KW - CLINICAL trials
KW - DATABASES
KW - PERIODONTITIS
N1 - Accession Number: 35830466; Martínez-Zapata, Ma José 1; Email Address: mmartinezz@santpau.cat Martí-Carvajal, Arturo Solà, Ivan Bolibar, Ignasi Expósito, José Ángel Rodriguez, Luciano García, Joan; Affiliation: 1: Iberoamerican Cochrane Center, Epidemiology and Public Health Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Source Info: Jan2009, Vol. 49 Issue 1, p44; Subject Term: BLOOD plasma; Subject Term: BLOOD platelets; Subject Term: CLINICAL trials; Subject Term: DATABASES; Subject Term: PERIODONTITIS; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
L3 - 10.1111/j.1537-2995.2008.01945.x
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DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2009-25201-001
AN - 2009-25201-001
AU - Davis, Maryann
AU - Green, Melanie
AU - Hoffman, Cheri
ED - Clark, Hewitt B.
ED - Unruh, Deanne K.
ED - Clark, Hewitt B., (Ed)
ED - Unruh, Deanne K., (Ed)
T1 - The service system obstacle course for transition-age youth and young adults.
T2 - Transition of youth and young adults with emotional or behavioral difficulties: An evidence-supported handbook.
Y1 - 2009///
SP - 25
EP - 46
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-963-5
SN - 978-1-55766-963-6
AD - Davis, Maryann, Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, MA, US, 01655
N1 - Accession Number: 2009-25201-001. Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20100301. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-963-5, Paperback; 978-1-55766-963-6, Paperback. Language: English. Major Descriptor: Government Policy Making; Independent Living Programs; Life Changes; Social Services. Minor Descriptor: Models. Classification: Community & Social Services (3373). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - In 1995, the Center for Mental Health Services of the Substance Abuse and Mental Health Services Administration (CMHS/SAMHSA) brought together a group of national experts on issues related to youth with mental health conditions and their transition to adulthood (Davis & Vander Stoep, 1996). During this meeting, these experts, including researchers, practitioners, policy makers, and family advocates, expressed concern about this group of young people and described their own observations or experiences in which they found inadequacies in service provision for these individuals. Davis and Vander Stoep (1997) reviewed the limited strands of research in the literature to summarize what was known about how well young adults fared during their transition into adulthood. The conclusions were alarming; in young adulthood, this group experienced high dropout rates, underemployment, poverty, homelessness, early pregnancy, and frequent trouble with the law. Around this time, Hewitt B. 'Rusty' Clark published his cornerstone paper summarizing common features among programs that had been nominated as strong and innovative in working with this group (Clark, Unger, & Stuart, 1993). From that work, Dr. Clark expanded those findings into what is currently recognized as the only comprehensive framework for community systems working with transition-age youth and young adults: the Transition to Independence Process (TIP) model (Clark & Foster-Johnson, 1996; see also Chapter 2). These three publications (Clark & Foster-Johnson, 1996; Clark et al., 1993; Davis & Vander Stoep, 1997) mark the beginning of a growth period in the field of services for transition-age youth. One of the consequences of the work done in this field since that time is an identification of many of this population's needs and a refinement of evidence-supported, if not evidence-based, practices. Development of good practice models is moot if they cannot be placed into service frameworks that support them. A review of the existing literature in 2005 (Davis & Koyanagi, 2005) allowed for extrapolation of the basic policy tenets that would support services consistent with the TIP model and research findings. Those tenets serve as a standard by which to judge progress. In this chapter we describe those policy tenets and use them as a basis from which to describe the literature on policy and system gaps. We begin by creating a picture. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - policy tenets
KW - policy & system gaps
KW - transition-age youth & young adults
KW - Transition to Independence Process model
KW - support services
KW - 2009
KW - Government Policy Making
KW - Independent Living Programs
KW - Life Changes
KW - Social Services
KW - Models
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-25201-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - CHAP
ID - 2009-25201-009
AN - 2009-25201-009
AU - Hoffman, Cheri
AU - Heflinger, Craig Anne
AU - Athay, Michele
AU - Davis, Maryann
ED - Clark, Hewitt B.
ED - Unruh, Deanne K.
ED - Clark, Hewitt B., (Ed)
ED - Unruh, Deanne K., (Ed)
T1 - Policy, funding, and sustainability: Issues and recommendations for promoting effective transition systems.
T2 - Transition of youth and young adults with emotional or behavioral difficulties: An evidence-supported handbook.
Y1 - 2009///
SP - 263
EP - 290
CY - Baltimore, MD, US
PB - Paul H Brookes Publishing
SN - 1-55766-963-5
SN - 978-1-55766-963-6
AD - Hoffman, Cheri, Vanderbilt Center for Nashville Studies, 1207 18th Avenue South, Nashville, TN, US, 37212
N1 - Accession Number: 2009-25201-009. Partial author list: First Author & Affiliation: Hoffman, Cheri; Vanderbilt Center for Nashville Studies, Nashville, TN, US. Release Date: 20100301. Correction Date: 20120618. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 1-55766-963-5, Paperback; 978-1-55766-963-6, Paperback. Language: English. Major Descriptor: Behavior Problems; Emotional Disturbances; Government Policy Making; Social Services; Health Care Policy. Minor Descriptor: Family; Funding; Life Changes. Classification: Community & Social Services (3373). Population: Human (10). Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 28.
AB - Numerous public systems serve the transition-age youth who are the focus of this book—child mental health, child welfare, education (particularly special education), juvenile justice, and others that may touch the lives of these youth as they approach adulthood. Vocational rehabilitation, adult mental health, corrections, employment services, substance abuse, housing, state higher education, and others may influence these young adults as they enter adulthood. Each of these systems has its own set of policies and funding mechanisms that affect the services they are able to provide to help prepare youth for impending young adulthood roles. Often, these youth and young adults cross these systems (i.e., a young person with EBD in foster care might receive special education services at school, or voluntarily continue in foster care services as they enter community college). As described in Chapter 1, navigating just one of these various systems with one of its particularities and barriers can be confusing, even daunting at times, much less navigating multiple systems at the same time. This chapter briefly reviews existing policies that affect transition-age youth and young adults and their families, examines the strengths of existing policies, and makes suggestions for ways to bolster them to facilitate smoother, stronger transitions. The chapter reports on funding and sustainability issues for transition service systems, and finally makes recommendations at the funding and policy level designed to set the occasion for the implementation of effective transition systems for these vulnerable youth and young adults and their families. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - policies
KW - transition-age youth & young adults
KW - family
KW - transition service systems
KW - funding
KW - sustainability issues
KW - emotional &/or behavioral difficulties
KW - 2009
KW - Behavior Problems
KW - Emotional Disturbances
KW - Government Policy Making
KW - Social Services
KW - Health Care Policy
KW - Family
KW - Funding
KW - Life Changes
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: T32MH019544-12. Other Details: Training Grant for Children's Mental Health Services Research. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-25201-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Garra, Brian S.
AU - Locher, Melanie
AU - Felker, Steven
AU - Wear, Keith A.
T1 - Measurements of Ultrasonic Backscattered Spectral Centroid Shift From Spine In Vivo: Methodology and Preliminary Results
JO - Ultrasound in Medicine & Biology
JF - Ultrasound in Medicine & Biology
Y1 - 2009/01//
VL - 35
IS - 1
M3 - Article
SP - 165
EP - 168
SN - 03015629
AB - Abstract: Ultrasonic backscatter measurements from vertebral bodies (L3 and L4) in nine women were performed using a clinical ultrasonic imaging system. Measurements were made through the abdomen. The location of a vertebra was identified from the bright specular reflection from the vertebral anterior surface. Backscattered signals were gated to isolate signal emanating from the cancellous interiors of vertebrae. The spectral centroid shift of the backscattered signal, which has previously been shown to correlate highly with bone mineral density (BMD) in human calcaneus in vitro, was measured. BMD was also measured in the nine subjects'' vertebrae using a clinical bone densitometer. The correlation coefficient between centroid shift and BMD was r = −0.61. The slope of the linear fit was −160 kHz / (g/cm2). The negative slope was expected because the attenuation coefficient (and therefore magnitude of the centroid downshift) is known from previous studies to increase with BMD. The centroid shift may be a useful parameter for characterizing bone in vivo. (E-mail: keith.wear@fda.hhs.gov) [Copyright &y& Elsevier]
AB - Copyright of Ultrasound in Medicine & Biology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SPINE -- Diseases
KW - DIAGNOSIS
KW - DIAGNOSTIC ultrasonic imaging
KW - BONE density
KW - BONE densitometry
KW - CLINICAL trials
KW - SCIENTIFIC method
KW - BACKSCATTERING
KW - Backscatter
KW - Bone
KW - Vertebra
N1 - Accession Number: 35659907; Garra, Brian S. 1 Locher, Melanie 1 Felker, Steven 1 Wear, Keith A. 2; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: University of Vermont Radiology Department, Burlington, VT, USA 2: US Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA; Source Info: Jan2009, Vol. 35 Issue 1, p165; Subject Term: SPINE -- Diseases; Subject Term: DIAGNOSIS; Subject Term: DIAGNOSTIC ultrasonic imaging; Subject Term: BONE density; Subject Term: BONE densitometry; Subject Term: CLINICAL trials; Subject Term: SCIENTIFIC method; Subject Term: BACKSCATTERING; Author-Supplied Keyword: Backscatter; Author-Supplied Keyword: Bone; Author-Supplied Keyword: Vertebra; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ultrasmedbio.2008.06.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35659907&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CHAP
ID - 2009-07257-026
AN - 2009-07257-026
AU - Conner, Latoya C.
AU - Le Fauve, Charlene E.
AU - Wallace, Barbara C.
ED - Brady, Kathleen T.
ED - Back, Sudie E.
ED - Greenfield, Shelly F.
ED - Brady, Kathleen T., (Ed)
ED - Back, Sudie E., (Ed)
ED - Greenfield, Shelly F., (Ed)
T1 - Ethnic and cultural correlates of addiction among diverse women.
T2 - Women and addiction: A comprehensive handbook.
Y1 - 2009///
SP - 453
EP - 474
CY - New York, NY, US
PB - Guilford Press
SN - 978-1-60623-107-4
N1 - Accession Number: 2009-07257-026. Partial author list: First Author & Affiliation: Conner, Latoya C.; Department of Educational Foundations and Counseling, Hunter College of The City University of New York, New York, NY, US. Release Date: 20090706. Correction Date: 20151207. Publication Type: Book (0200), Edited Book (0280). Format Covered: Print. Document Type: Chapter. Book Type: Handbook/Manual. ISBN: 978-1-60623-107-4, Hardcover. Language: English. Major Descriptor: Diversity; Drug Addiction; Epidemiology; Human Females; Racial and Ethnic Groups. Minor Descriptor: Alaska Natives; American Indians; Asians; Blacks; Drug Rehabilitation; Sociocultural Factors; Latinos/Latinas. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Female (40). Location: US. Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 22.
AB - The purpose of this chapter is to provide a cultural and contextual framework for understanding addictions among women of diverse backgrounds. The chapter (1) introduces the ethnic and cultural correlates of addictions; (2) presents epidemiological data on the prevalence of substance use and treatment among African American, Native American/Alaska Native, Latino, and Asian American women; (3) provides the historical contexts that give rise to the culture of addiction among women from diverse ethnic groups; and (4) summarizes current empirical research, evidence-based prevention, and culturally specific clinical treatment geared toward addiction recovery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnic & cultural correlates
KW - addictions
KW - diverse women
KW - epidemiology
KW - treatment
KW - African Americans
KW - Native American & Alaska Natives
KW - Latinos
KW - Asian Americans
KW - 2009
KW - Diversity
KW - Drug Addiction
KW - Epidemiology
KW - Human Females
KW - Racial and Ethnic Groups
KW - Alaska Natives
KW - American Indians
KW - Asians
KW - Blacks
KW - Drug Rehabilitation
KW - Sociocultural Factors
KW - Latinos/Latinas
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07257-026&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18925-001
AN - 2008-18925-001
AU - van Laere, Igor
AU - de Wit, Matty
AU - Klazinga, Niek
T1 - Evaluation of the signalling and referral system for households at risk of eviction in Amsterdam.
JF - Health & Social Care in the Community
JO - Health & Social Care in the Community
JA - Health Soc Care Community
Y1 - 2009/01//
VL - 17
IS - 1
SP - 1
EP - 8
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0966-0410
SN - 1365-2524
AD - van Laere, Igor, GGD Municipal Public Health Service, Community Mental Health Department, Dr Valckenier Outreach Practice for the Homeless, PO Box 2200, 1000 CE, Amsterdam, Netherlands
N1 - Accession Number: 2008-18925-001. PMID: 19125966 Partial author list: First Author & Affiliation: van Laere, Igor; GGD Municipal Public Health Service, Amsterdam, Netherlands. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Welfare Services; Homeless; Household Management. Classification: Community & Social Services (3373). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2009. Publication History: Accepted Date: Mar 20, 2008. Copyright Statement: The Authors. 2008.
AB - In Amsterdam, over 1400 households are evicted each year. We describe the results of an evaluation of the functioning of the signalling and referral system, set up for households at risk of eviction, through a qualitative and quantitative study. Interviews and questionnaires completed by employees of 12 housing associations (for rent arrears) and by employees of 13 nuisance control care networks (for nuisance), were used. Data on households with rent arrears, for which a court eviction order was requested, were collected prospectively in September and October 2003, and retrospectively on households causing nuisance and/or who were known to be evicted due to nuisance in 2001-2003. Functioning of signalling, of the 'alarm' of problems underlying rent arrears and/or nuisance, was evaluated by the extent of problems that were identified by the employees. Functioning of referral was evaluated by comparing the identified problems with the assistance contacts. For 275 households with rent arrears, housing associations reported social problems in 196 (71%), of whom 94 (48%) were in contact with social assistance, and medical problems in 62 (23%) of whom 18 (29%) were in contact with medical assistance. House visits resulted in a much higher identification of problems, and were associated with a reduced eviction risk [relative risk 0.57 (95% confidence interval: 0.43-0.75)]. For 190 nuisance households, nuisance control care networks reported social problems in 103 (54%), of which 13 (13%) were in contact with social assistance, and medical problems in 155 (82%), of which 142 (92%) were in contact with medical assistance. To prevent evictions in Amsterdam, housing associations should improve their signalling role by conducting more house visits, and they should refer more households to medical assistance. Nuisance control care networks should refer more households to social assistance. Only a systematic and integrated approach can keep more households at home. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - signaling systems
KW - referral systems
KW - households
KW - eviction
KW - homeless
KW - 2009
KW - Community Welfare Services
KW - Homeless
KW - Household Management
KW - 2009
DO - 10.1111/j.1365-2524.2007.00790.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18925-001&site=ehost-live&scope=site
UR - ivlaere@ggd.amsterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18759-001
AN - 2008-18759-001
AU - Acton, Kelly
AU - Bullock, Ann
T1 - Smoking in American Indian and Alaska Native people with diabetes revisited.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/01//
VL - 99
IS - 1
SP - 4
EP - 4
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Acton, Kelly, 5300 Homestead Rd NE, Albuquerque, NM, US, 87110
N1 - Accession Number: 2008-18759-001. PMID: 19008497 Partial author list: First Author & Affiliation: Acton, Kelly; National Division of Diabetes Treatment and Prevention, Indian Health Service, Albuquerque, NM, US. Release Date: 20091116. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Comment/Reply. Language: English. Major Descriptor: Alaska Natives; American Indians; Diabetes Mellitus; Tobacco Smoking. Minor Descriptor: Clinics; Comorbidity; Epidemiology; Health Care Services; Public Health Services; Smoking Cessation; Type 2 Diabetes. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 1. Issue Publication Date: Jan, 2009. Publication History: Accepted Date: Jul 29, 2008.
AB - Comments on an article by D. J. Morton et al. (see record [rid]2008-02659-030[/rid]). The author's article on smoking and diabetes in American Indians and Alaska Natives raises important concerns. Because of the longstanding organized emphasis on smoking ascertainment and cessation for individuals with diabetes, the findings likely reflect a serious ascertainment bias. Data presented in the report are also subject to other limitations; notably, the case definition may have compromised the accuracy of case identification, and the duration of monitoring cases may have been affected by a differential risk of mortality. To the extent that the risk of premature death is higher for smokers with diabetes than for those without diabetes, smokers who survived to be included in the study may have included fewer persons with diabetes. Thus, before the distribution of currently limited IHS smoking cessation resources is modified, the evidence for redistributing those resources should be more substantial than that presented by Morton et al. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - current smoking
KW - type 2 diabetes
KW - Indian Health Service clinics
KW - smoking prevalence
KW - American Indian/Alaska Natives
KW - 2009
KW - Alaska Natives
KW - American Indians
KW - Diabetes Mellitus
KW - Tobacco Smoking
KW - Clinics
KW - Comorbidity
KW - Epidemiology
KW - Health Care Services
KW - Public Health Services
KW - Smoking Cessation
KW - Type 2 Diabetes
KW - 2009
DO - 10.2105/AJPH.2008.148429
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18759-001&site=ehost-live&scope=site
UR - kelly.acton@ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00319-005
AN - 2009-00319-005
AU - Ferguson, Sherry A.
AU - Gopee, Neera V.
AU - Paule, Merle G.
AU - Howard, Paul C.
T1 - Female mini-pig performance of temporal response differentiation, incremental repeated acquisition, and progressive ratio operant tasks.
JF - Behavioural Processes
JO - Behavioural Processes
JA - Behav Processes
Y1 - 2009/01//
VL - 80
IS - 1
SP - 28
EP - 34
CY - Netherlands
PB - Elsevier Science
SN - 0376-6357
SN - 1872-8251
AD - Ferguson, Sherry A., Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, Jefferson, AR, US, 72079
N1 - Accession Number: 2009-00319-005. PMID: 18804519 Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20090126. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Learning; Motivation; Operant Conditioning; Pigs. Classification: Learning & Motivation (2420). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jan, 2009.
AB - Increased knowledge of the cognitive abilities of mini-pigs is needed due to their increasing use in behavioral neuroscience research. Here, six female Yucatan mini-pigs performed tasks thought to measure timing behavior (temporal response differentiation, TRD), learning (incremental repeated acquisition, IRA), and motivation (progressive ratio, PR). Daily 30-min sessions for food reinforcers required a lever press be maintained for at least 10 but no longer than 14 s (TRD), learning a new sequence of lever presses each test day (IRA) or an escalating number of presses for subsequent reinforcers (PR). All animals performed PR two days/week while three performed TRD five days/week and the other three performed IRA five days/week. Over the four test weeks, no animal completed TRD training and only one appeared to progress. For this task, lever press maintenance appeared difficult since by choice, the pigs used a front hoof, rather than the snout, to press the lever. IRA subjects showed gradually increasing performance with response rates comparable to those of rats but below those of children and monkeys and accuracy below that for rats. PR response rates were higher than those typically reported for rats, but lower than for adult rhesus monkeys or children. Physical differences in the way that each species responds likely account for these differences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mini-pigs
KW - learning
KW - motivation
KW - operant behavior
KW - timing
KW - neurocognitive ability
KW - 2009
KW - Animal Learning
KW - Motivation
KW - Operant Conditioning
KW - Pigs
KW - 2009
DO - 10.1016/j.beproc.2008.08.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00319-005&site=ehost-live&scope=site
UR - Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00105-002
AN - 2009-00105-002
AU - Manderscheid, Ronald W.
AU - Atay, Joanne E.
AU - Crider, Raquel A.
T1 - Changing trends in state psychiatric hospital use from 2002 to 2005.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/01//
VL - 60
IS - 1
SP - 29
EP - 34
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Manderscheid, Ronald W., Global Health Sector, SRA International, Inc., 6003 Executive Blvd., Rockville, MD, US, 20852
N1 - Accession Number: 2009-00105-002. PMID: 19114567 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Manderscheid, Ronald W.; Global Health Sector, SRA International, Inc., Rockville, MD, US. Release Date: 20090511. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Medical Residency; Mental Health Services; Psychiatric Hospitals. Minor Descriptor: Trends. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jan, 2009.
AB - Objective: National surveys have shown dramatic declines in the number of residents in state psychiatric hospitals since the 1950s and in the number of admissions since the 1970s. However, data from 2002 and 2005 indicate a reversal of these long-term trends. The objective of this study was to present the new data and to advocate for research on the factors contributing to these changes. Methods: This study is based on state-level data submitted annually to the Center for Mental Health Services. The 11 states showing increases in admissions and residents between 2002 and 2005 were surveyed by telephone about the factors leading to the changes. Results: Between 2002 and 2005, the number of admissions nationwide increased 21.1%, and the number of residents increased by 1.0%. State mental health agency staff attributed the increases principally to one factor—the increase in the number of forensic admissions and residents. Staff also identified increases in the number of admissions with schizophrenia (increased 23.2%) and affective disorders (increased 16.3%) as a second factor, plus declines in the availability of housing and community-based care providers. Conclusions: The reversal of long-term trends may signal threats to the goal of community-based mental health care. Research is urgently needed to examine the factors associated with these increases. Potential factors to be investigated include the increase in the number of forensic admissions and the antecedents of this phenomenon, increases in the number of admissions with schizophrenia, the changing capacity of general hospital inpatient psychiatric services in the community, and changes in the demographic makeup of American society, reflected in an aging population and increased racial-ethnic diversity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - long-term trends
KW - state psychiatric hospitals
KW - mental health services
KW - residents
KW - 2009
KW - Medical Residency
KW - Mental Health Services
KW - Psychiatric Hospitals
KW - Trends
KW - 2009
DO - 10.1176/appi.ps.60.1.29
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00105-002&site=ehost-live&scope=site
UR - ronald_manderscheid@sra.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01067-004
AN - 2009-01067-004
AU - Choi, Sunha
AU - Rozario, Philip
AU - Morrow-Howell, Nancy
AU - Proctor, Enola
T1 - Elders with first psychiatric hospitalization for depression.
JF - International Journal of Geriatric Psychiatry
JO - International Journal of Geriatric Psychiatry
JA - Int J Geriatr Psychiatry
Y1 - 2009/01//
VL - 24
IS - 1
SP - 33
EP - 40
CY - US
PB - John Wiley & Sons
SN - 0885-6230
SN - 1099-1166
AD - Choi, Sunha, 67 Washington St, PO Box 6000, Binghamton, NY, US, 13902-6000
N1 - Accession Number: 2009-01067-004. PMID: 18543349 Partial author list: First Author & Affiliation: Choi, Sunha; Department of Social Work, State University of New York at Binghamton, Binghamton, NY, US. Release Date: 20090706. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Geriatric Psychiatry; Hospital Admission; Hospitalized Patients; Major Depression. Minor Descriptor: Geriatric Patients; Health Care Utilization; Patient History. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Social Resource Rating Scale; Mini Mental State Examination; Brief Psychiatric Rating Scale DOI: 10.1037/t01554-000; Geriatric Depression Scale DOI: 10.1037/t00930-000; Global Assessment of Function Scale; Cumulative Illness Rating Scale; Global Assessment of Functioning Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2009.
AB - Objective: Little is known about the first psychiatric hospitalization episode of older adults with depression. The purpose of this study is to describe the proportion and characteristics of first-time inpatients admitted for late-life depression. Methods: Guided by the Network Episode Model and the Andersen model, this study identifies and compares the characteristics of depressed older adults with (n = 108) and those without (n = 77) prior psychiatric hospitalization, upon admission into the geropsychiatric unit, using logistic regression. Data on a lifetime history of inpatient psychiatric treatment, clinical characteristics, demographics, social resources, and psychosocial/medical service use were obtained from patients' medical records and self-reports. Results: Compared with patients who had prior psychiatric admission, first-time inpatients were associated with having: (1) late-onset depression (OR = 14.99); (2) no lifetime psychotic symptoms (OR = 0.21); (3) lower scores on the Brief Psychiatric Rating Scale (BPRS) at admission (OR = 0.96); (4) higher numbers of doctors seen (OR = 1.46); and (5) lower use of senior centers 6 months prior to the admission (OR = 0.12). Conclusions: Depressed older adults' prior psychiatric inpatient service utilization is closely related to their past and current psychiatric needs. Also, the two groups show significant differences in health and social service use prior to the psychiatric hospitalization. However, severity of depression at admission was not different. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - older adults
KW - first psychiatric hospitalization
KW - major depression
KW - patient characteristics
KW - patient history
KW - health service use
KW - geriatric patients
KW - 2009
KW - Client Characteristics
KW - Geriatric Psychiatry
KW - Hospital Admission
KW - Hospitalized Patients
KW - Major Depression
KW - Geriatric Patients
KW - Health Care Utilization
KW - Patient History
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: RO1MH56208. Other Details: Conducted through the Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University. Recipients: No recipient indicated
DO - 10.1002/gps.2064
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01067-004&site=ehost-live&scope=site
UR - shchoi@binghamton.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-19197-003
AN - 2008-19197-003
AU - Ogbuanu, Chinelo A.
AU - Jones, Candace A.
AU - McTigue, James F.
AU - Baker, Samuel L.
AU - Heim, Marge
AU - Baek, JongDeuk
AU - Smith, Lillian U.
T1 - A program evaluation of postpartum/newborn home visitation services in Aiken County, South Carolina.
JF - Public Health Nursing
JO - Public Health Nursing
JA - Public Health Nurs
Y1 - 2009/01//Jan-Feb, 2009
VL - 26
IS - 1
SP - 39
EP - 47
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0737-1209
SN - 1525-1446
AD - Ogbuanu, Chinelo A., Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Columbia, SC, US, 29208
N1 - Accession Number: 2008-19197-003. PMID: 19154191 Partial author list: First Author & Affiliation: Ogbuanu, Chinelo A.; Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC, US. Other Publishers: Blackwell Publishing. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Promotion; Home Visiting Programs; Monitoring; Program Evaluation. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140). Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan-Feb, 2009. Copyright Statement: The Authors. 2009.
AB - Objective: Home visiting programs for very young children seek to promote their health and development. We conducted a process and outcome evaluation of the Postpartum/Newborn Home Visit (PPNBHV) service in 1 county. Design: A retrospective study of Aiken County Health records of live infant births in 2004 was conducted. Sample: A random sample of 176 infants who were born in 2004 and enrolled in the women, infants, and children's (WIC) program in the same year was selected. Measures: Process measures include timeliness of the home visit, and appropriateness of revisits. Outcome measures include age at WIC enrollment and immunization status at 6/9 months. Results: Of the 176 infants, 76 (43%) received a home visit. Of these, 13 (17%) received the visit within the stipulated time frame. After controlling for potential confounders, infants who received a home visit were 4 times (95% CI 1.92-8.36) as likely to enroll early in the WIC program compared with those who did not. Conclusion: The PPNBHV service may contribute to early enrollment in the WIC program. Improvement in the timeliness of the visits is needed. Program monitoring and evaluation are necessary to ensure adherence, measure outcomes, and provide feedback for continuous quality improvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - newborn home visitation services
KW - South Carolina
KW - program evaluation
KW - health promotion
KW - 2009
KW - Health Promotion
KW - Home Visiting Programs
KW - Monitoring
KW - Program Evaluation
KW - 2009
DO - 10.1111/j.1525-1446.2008.00752.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-19197-003&site=ehost-live&scope=site
UR - ogbuanu@mailbox.sc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02217-007
AN - 2009-02217-007
AU - McCarty, Dennis
AU - Gustafson, David
AU - Capoccia, Victor A.
AU - Cotter, Frances
T1 - Improving care for the treatment of alcohol and drug disorders.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2009/01//
VL - 36
IS - 1
SP - 52
EP - 60
CY - Germany
PB - Springer
SN - 1094-3412
AD - McCarty, Dennis, Department of Public Health and Preventive Medicine, Oregon Health and Science University, CB669, 3181 S.W. Sam Jackson Park Road, Portland, OR, US, 97239-3098
N1 - Accession Number: 2009-02217-007. PMID: 18259871 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: McCarty, Dennis; Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20090309. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Addiction Health Services Research Conference, 2006, Little Rock, AR, US. Conference Note: An earlier version of this paper was presented at the aforementioned conference. Major Descriptor: Drug Rehabilitation; Health Care Delivery; Organizational Change; Quality of Care; Quality of Services. Minor Descriptor: Alcohol Rehabilitation. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2009.
AB - The Network for the Improvement of Addiction Treatment (NIATx) teaches alcohol and drug treatment programs to apply process improvement strategies and make organizational changes that improve quality of care. Participating programs reduce days to admission, increase retention in care, and spread the application of process improvement within their treatment centers. More generally, NIATx provides a framework for addressing the Institute of Medicine’s six dimensions of quality care (i.e., safe, effective, patient-centered, efficient, timely, and equitable) in treatments for alcohol, drug, and mental health disorders. NIATx and its extensions illustrate how the behavioral health field can respond to the demand for higher quality treatment services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - drug & alcohol treatment programs
KW - quality of care
KW - treatment quality
KW - organizational change
KW - Network for the Improvement of Addiction Treatment
KW - 2009
KW - Drug Rehabilitation
KW - Health Care Delivery
KW - Organizational Change
KW - Quality of Care
KW - Quality of Services
KW - Alcohol Rehabilitation
KW - 2009
DO - 10.1007/s11414-008-9108-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02217-007&site=ehost-live&scope=site
UR - frances.cotter@samhsa.hhs.gov
UR - vcapoccia@sorosny.org
UR - dhgustaf@facstaff.wisc.edu
UR - mccartyd@ohsu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00860-005
AN - 2009-00860-005
AU - Wolff, Nancy
AU - Shi, Jing
T1 - Contextualization of physical and sexual assault in male prisons: Incidents and their aftermath.
JF - Journal of Correctional Health Care
JO - Journal of Correctional Health Care
JA - J Correct Health Care
Y1 - 2009/01//
VL - 15
IS - 1
SP - 58
EP - 77
CY - US
PB - Sage Publications
SN - 1078-3458
SN - 1940-5200
AD - Wolff, Nancy, Center for Mental Health Services Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2009-00860-005. PMID: 19477812 Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20091130. Correction Date: 20111107. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Males; Physical Abuse; Prisoners; Sexual Abuse; Victimization. Minor Descriptor: Contextual Associations. Classification: Behavior Disorders & Antisocial Behavior (3230). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 20. Issue Publication Date: Jan, 2009. Copyright Statement: NCCHC. 2009.
AB - Physical and sexual assault are part of the prison experience. Approximately 21% of male inmates are physically assaulted during a 6-month period. Sexual assault is estimated at between 2% and 5%. Although prevalence evidence is growing, less is known about circumstances surrounding and resulting from these incidents. This article presents an analysis of approximately 2,200 physical and 200 sexual victimizations reported by a random sample of 6,964 male inmates. Physical injury occurred in 40% of physical assaults and 70% of sexual assaults between inmates and in 50% of assaults perpetrated by staff. Emotional reactions to assaults were experienced by virtually all victims. Context information is vital in the development and implementation of prevention and therapeutic interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - contextualization
KW - physical assault
KW - sexual assault
KW - male prisons
KW - victimizations
KW - 2009
KW - Human Males
KW - Physical Abuse
KW - Prisoners
KW - Sexual Abuse
KW - Victimization
KW - Contextual Associations
KW - 2009
U1 - Sponsor: Office of Justice Programs. Grant: OJP-2004-RP-BX-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20 MH66170. Recipients: No recipient indicated
DO - 10.1177/1078345808326622
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00860-005&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00974-010
AN - 2009-00974-010
AU - Strine, Tara W.
AU - Kroenke, Kurt
AU - Dhingra, Satvinder
AU - Balluz, Lina S.
AU - Gonzalez, Olinda
AU - Berry, Joyce T.
AU - Mokdad, Ali H.
T1 - The associations between depression, health-related quality of life, social support, life satisfaction, and disability in community-dwelling US adults.
JF - Journal of Nervous and Mental Disease
JO - Journal of Nervous and Mental Disease
JA - J Nerv Ment Dis
Y1 - 2009/01//
VL - 197
IS - 1
SP - 61
EP - 64
CY - US
PB - Lippincott Williams & Wilkins
SN - 0022-3018
SN - 1539-736X
AD - Strine, Tara W., Division of Adult and Community Health, Center for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K-66, Atlanta, GA, US, 30341
N1 - Accession Number: 2009-00974-010. PMID: 19155812 Partial author list: First Author & Affiliation: Strine, Tara W.; Center for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20090706. Correction Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Life Satisfaction; Major Depression; Quality of Life; Social Support. Minor Descriptor: Disabilities. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Behavioral Risk Factor Surveillance System; Patient Health Questionnaire DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Jan, 2009.
AB - The purpose of this manuscript is to describe the associations among current depression, as measured by the Patient Health Questionnaire 8, health-related quality of life, social support, life satisfaction, and disability status, using the 2006 Behavioral Risk Factor Surveillance System. A dose-response relationship exists between depression severity and mean number of days in the past 30 days of physical distress, pain, anxiety symptoms, and activity limitations as well as the prevalence of fair/poor general health, life dissatisfaction, inadequate social support, and disability. These profound associations underscore the need for recognition and treatment of depression in all healthcare settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - health-related quality of life
KW - social support
KW - life satisfaction
KW - disabilities
KW - 2009
KW - Health
KW - Life Satisfaction
KW - Major Depression
KW - Quality of Life
KW - Social Support
KW - Disabilities
KW - 2009
DO - 10.1097/NMD.0b013e3181924ad8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00974-010&site=ehost-live&scope=site
UR - tws2@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03041-006
AN - 2009-03041-006
AU - Pine, Michael
AU - Jordan, Harmon S.
AU - Elixhauser, Anne
AU - Fry, Donald E.
AU - Hoaglin, David C.
AU - Jones, Barbara
AU - Meimban, Roger
AU - Warner, David
AU - Gonzales, Junius
T1 - Modifying ICD-9-CM coding of secondary diagnoses to improve risk-adjustment of inpatient mortality rates.
JF - Medical Decision Making
JO - Medical Decision Making
JA - Med Decis Making
Y1 - 2009/01//Jan-Feb, 2009
VL - 29
IS - 1
SP - 69
EP - 81
CY - US
PB - Sage Publications
SN - 0272-989X
SN - 1552-681X
AD - Pine, Michael, 1210 Chicago Avenue, Ste 503, Evanston, IL, US, 60202
N1 - Accession Number: 2009-03041-006. PMID: 18812585 Partial author list: First Author & Affiliation: Pine, Michael; Michael Pine and Associates, Inc., University of Chicago, Chicago, IL, US. Release Date: 20090511. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diagnosis; Hospitalized Patients; International Classification of Diseases; Mortality Rate; Risk Factors. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jan-Feb, 2009.
AB - Objective: To assess the effect on risk-adjustment of inpatient mortality rates of progressively enhancing administrative claims data with clinical data that are increasingly expensive to obtain. Data Sources: Claims and abstracted clinical data on patients hospitalized for 5 medical conditions and 3 surgical procedures at 188 Pennsylvania hospitals from July 2000 through June 2003. Methods: Risk-adjustment models for inpatient mortality were derived using claims data with secondary diagnoses limited to conditions unlikely to be hospital-acquired complications. Models were enhanced with one or more of 1) secondary diagnoses inferred from clinical data to have been present-on-admission (POA), 2) secondary diagnoses not coded on claims but documented in medical records as POA, 3) numerical laboratory results from the first hospital day, and 4) all available clinical data from the first hospital day. Alternative models were compared using c-statistics, the magnitude of errors in prediction for individual cases, and the percentage of hospitals with aggregate errors in prediction exceeding specified thresholds. Results: More complete coding of a few underreported secondary diagnoses and adding numerical laboratory results to claims data substantially improved predictions of inpatient mortality. Little improvement resulted from increasing the maximum number of available secondary diagnoses or adding additional clinical data. Conclusions: Increasing the completeness and consistency of reporting a few secondary diagnosis codes for findings POA and merging claims data with numerical laboratory values improved risk adjustment of inpatient mortality rates. Expensive abstraction of additional clinical information from medical records resulted in little further improvement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk adjustment
KW - inpatient mortality rates
KW - ICD-9-CM coding
KW - secondary diagnoses
KW - 2009
KW - Diagnosis
KW - Hospitalized Patients
KW - International Classification of Diseases
KW - Mortality Rate
KW - Risk Factors
KW - 2009
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 233–02–0088. Recipients: No recipient indicated
DO - 10.1177/0272989X08323297
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03041-006&site=ehost-live&scope=site
UR - michaelorjoan@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02086-008
AN - 2009-02086-008
AU - Dalsey, Elizabeth
AU - Park, Hee Sun
T1 - Implication of organizational health policy on organizational attraction.
JF - Health Communication
JO - Health Communication
JA - Health Commun
Y1 - 2009/01//
VL - 24
IS - 1
SP - 71
EP - 81
CY - United Kingdom
PB - Taylor & Francis
SN - 1041-0236
SN - 1532-7027
AD - Park, Hee Sun, Department of Communication, Michigan State University, East Lansing, MI, US, 48824-1212
N1 - Accession Number: 2009-02086-008. PMID: 19204860 Partial author list: First Author & Affiliation: Dalsey, Elizabeth; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Other Publishers: Lawrence Erlbaum. Release Date: 20090302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Promotion; Organizational Characteristics; Policy Making; Smoking Cessation; Tobacco Smoking. Minor Descriptor: Job Characteristics; Occupational Choice. Classification: Organizational Behavior (3660). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jan, 2009.
AB - This study investigated both smoking and nonsmoking undergraduates’ reactions to an organization implementing a policy that either mandated or recommended that employees quit smoking. Undergraduate participants (N = 296) were randomly assigned to 1 of 2 (high vs. low severity of a smoke-free policy implementation) × 2 (high vs. low organizational assistance) conditions and indicated their organizational attraction for a hypothetical organization, imagining themselves as job applicants. The findings showed that organizational attraction was affected by the level of organizational assistance but not by the level of severity. These and other findings concerning individuals’ perceived severity, perceived organizational support, smoking sensitivity, and employer control are presented in detail, and the implications thereof are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - organizational health policy
KW - organizational attraction
KW - smokers & nonsmokers
KW - undergraduate reactions
KW - smoke free policy
KW - organizational assistance & support
KW - 2009
KW - Health Promotion
KW - Organizational Characteristics
KW - Policy Making
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Job Characteristics
KW - Occupational Choice
KW - 2009
DO - 10.1080/10410230802607016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02086-008&site=ehost-live&scope=site
UR - heesun@msu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00129-009
AN - 2009-00129-009
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - Siahpush, Mohammad
AU - van Dyck, Peter C.
T1 - Prevalence and correlates of state and regional disparities in vigorous physical activity levels among US children and adolescents.
JF - Journal of Physical Activity & Health
JO - Journal of Physical Activity & Health
JA - J Phys Act Health
Y1 - 2009/01//
VL - 6
IS - 1
SP - 73
EP - 87
CY - US
PB - Human Kinetics
SN - 1543-3080
SN - 1543-5474
AD - Singh, Gopal K., Maternal and Child Health Bureau, Health Resources and Services Administration, US Dept of Health and Human Services, Rockville, MD, US, 20857
N1 - Accession Number: 2009-00129-009. PMID: 19211960 Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Dept of Health and Human Services, Rockville, MD, US. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Activity Level; Physical Activity; Regional Differences. Minor Descriptor: Epidemiology. Classification: Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Jan, 2009. Copyright Statement: Human Kinetics, Inc. 2009.
AB - Background: This study examines state and regional disparities in vigorous physical activity levels among US children age 6 to 17 years. Methods: The 2003 National Survey of Children’s Health was used to calculate vigorous physical activity (VPA) and no days of vigorous physical activity (NVPA) prevalence by state and geographic region. Logistic and least squares regression were used to analyze geographic disparities. Results: Vigorous physical activity levels varied substantially across geographic areas, with the East South-central region of the US having the highest NVPA prevalence (13.4%) and the Pacific region the lowest prevalence (9.1%). Children in Georgia and Tennessee had 2.2 to 2.3 times higher odds and children in DC, Oklahoma, Arkansas, Indiana, Kentucky, Kansas, New Jersey, South Carolina, and Washington (adjusted prevalence >13.4%) had 1.8 to 2.0 times higher odds of NVPA than children in California (adjusted prevalence = 8.4%). Adjustment for race/ethnicity, socioeconomic status, social capital, television viewing, sleep behavior, and parental physical activity doubled the magnitude of geographic disparities in vigorous physical activity levels. Area poverty, income inequality, and violent crime rates were independent predictors of VPA and NVPA. Conclusions: Although individual and area-level socioeconomic factors are important predictors, substantial geographic disparities remain, with children in several Southern states having particularly high risks of NVPA. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - prevalence
KW - state disparities
KW - regional disparities
KW - vigorous physical activity levels
KW - children
KW - adolescents
KW - 2009
KW - Activity Level
KW - Physical Activity
KW - Regional Differences
KW - Epidemiology
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00129-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01542-016
AN - 2009-01542-016
AU - Dekker, Anthony
AU - Kushner, Marla
T1 - In memoriam: Martin C. Doot, MD.
JF - Journal of Addictive Diseases
JO - Journal of Addictive Diseases
JA - J Addict Dis
Y1 - 2009/01//
VL - 28
IS - 1
SP - 87
EP - 88
CY - United Kingdom
PB - Taylor & Francis
SN - 1055-0887
SN - 1545-0848
AD - Dekker, Anthony
N1 - Accession Number: 2009-01542-016. Other Journal Title: Advances in Alcohol & Substance Abuse. Partial author list: First Author & Affiliation: Dekker, Anthony; Office of Health Programs, Phoenix Area Office, Indian Health Service, AZ, US. Other Publishers: Haworth Press. Release Date: 20090713. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Obituary. Language: English. Major Descriptor: Accountability; Addiction; Drug Rehabilitation; Scientific Communication; Health Personnel. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Page Count: 2. Issue Publication Date: Jan, 2009.
AB - Martin 'Marty' C. Doot, MD was a remarkable leader and advocate for those burdened with the disease of addiction. On November 14, 2008, Martin C. Doot, 60, of Villa Park, Illinois died suddenly while running with friends in Oak Brook, IL. Dr. Doot was the medical director of the Advocate addiction treatment program and medical director of the Illinois Professionals Health Program that provides a support and accountability for health professionals in need, many of whom were burdened with addictions. Dr. Doot was a graduate of the Chicago Christian High School in Palos Heights and for two years attended Trinity Christian College in Palos Heights, where he met Judy, his future wife. He finished his education at the University of Illinois, Urbana-Champaign, where he received a bachelor of science in general biology in 1969. Dr. Doot received his medical degree from Loyola University in Chicago in 1973. Additionally, he published many articles, book chapters and educational materials on substance abuse and addiction medicine. He welcomed and trained many osteopathic students in addiction medicine. 'He was an empathetic human being who cared about people that have a disease, and he wanted to see them get better.' Dr. Doot is survived by his wife Judy; children; grandchildren; mother Dora; mother-in- law; brother; sister; brother-in-law; and sisters-in-law. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Martin C. Doot
KW - addiction treatment program
KW - medical director
KW - accountability
KW - health professionals
KW - 2009
KW - Accountability
KW - Addiction
KW - Drug Rehabilitation
KW - Scientific Communication
KW - Health Personnel
KW - 2009
DO - 10.1080/10550880802665339
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01542-016&site=ehost-live&scope=site
UR - Anthony.dekker@ihs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-18445-015
AN - 2008-18445-015
AU - Han, Beth
AU - Gfroerer, Joseph C.
AU - Colliver, James D.
AU - Penne, Michael A.
T1 - Substance use disorder among older adults in the United States in 2020.
JF - Addiction
JO - Addiction
JA - Addiction
Y1 - 2009/01//
VL - 104
IS - 1
SP - 88
EP - 96
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0965-2140
SN - 1360-0443
AD - Han, Beth, 1 Choke Cherry Road, Room 7-1010, Rockville, MD, US, 20857
N1 - Accession Number: 2008-18445-015. PMID: 19133892 Other Journal Title: British Journal of Addiction. Partial author list: First Author & Affiliation: Han, Beth; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20090406. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Dependency. Minor Descriptor: Substance Use Disorder. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: National Survey on Drug Use and Health. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2009.
AB - Aims: This study aimed to project the number of people aged 50 years or older with substance use disorder (alcohol/illicit drug dependence or abuse) in the United States in 2020. Design: Logistic regression models were applied to estimate parameters predicting past-year substance use disorder using the 2002–06 National Survey on Drug Use and Health data. We applied these parameters to the projected US 2020 population to estimate the number of adults aged 50 or older with substance use disorder in 2020. Setting: Non-institutionalized US residences. Participants: Representative sample of the US civilian, non-institutionalized population. Measurements: Substance use disorder is classified based on criteria in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Findings: Due to the large population size and high substance use rate of the baby-boom cohort, the number of adults aged 50 or older with substance use disorder is projected to double from 2.8 million (annual average) in 2002–06 to 5.7 million in 2020. Increases are projected for all examined gender, race/ethnicity and age groups. Conclusions: Our estimates provide critical information for policymakers to allocate resources and develop prevention and treatment approaches to address future needs of the US older adult population with substance use disorder. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - substance use disorder
KW - older adults
KW - US
KW - illicit drug dependence
KW - 2009
KW - Drug Abuse
KW - Drug Dependency
KW - Substance Use Disorder
KW - 2009
DO - 10.1111/j.1360-0443.2008.02411.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-18445-015&site=ehost-live&scope=site
UR - beth.han@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-04064-012
AN - 2010-04064-012
AU - Charles, Luenda E.
AU - Loomis, Dana
AU - Demissie, Zewditu
T1 - Occupational hazards experienced by cleaning workers and janitors: A review of the epidemiologic literature.
JF - Work: Journal of Prevention, Assessment & Rehabilitation
JO - Work: Journal of Prevention, Assessment & Rehabilitation
JA - Work
Y1 - 2009///
VL - 34
IS - 1
SP - 105
EP - 116
CY - Netherlands
PB - IOS Press
SN - 1051-9815
SN - 1875-9270
AD - Charles, Luenda E., National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, 1095 Willowdale Rd., Mail Stop L-4050, Morgantown, WV, US, 26505-2845
N1 - Accession Number: 2010-04064-012. PMID: 19923681 Partial author list: First Author & Affiliation: Charles, Luenda E.; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Release Date: 20101220. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Hazards; Health; Occupational Exposure; Personnel. Classification: Occupational & Vocational Rehabilitation (3384). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 12. Issue Publication Date: 2009. Publication History: Accepted Date: Jan 5, 2009; First Submitted Date: Nov 24, 2008. Copyright Statement: All rights reserved. IOS Press and the authors. 2009.
AB - Building cleaners are an important group of workers who experience diverse occupational hazards resulting in health problems. A review of epidemiologic studies conducted between 1981 and 2005 was performed using PubMed and PsychLit, to identify health outcomes and the associated hazards in the work environment of cleaners. Among 35 studies, respiratory diseases (n = 17) and dermatologic diseases (n = 9) were the most common and were associated with exposure to cleaning agents, wet work, and rubber latex. The potential for infectious diseases (n = 3) was identified among cleaners in medical laboratories and was associated with exposure to broken glass and uncapped needles in the trash. Musculoskeletal disorders (n = 5) were associated with several physical stressors (e.g., awkward postures, prolonged standing) and psychosocial stressors (e.g., monotonous job, low potential for promotion). Mental disorders (n = 1) were also associated with psychosocial stressors and societal stigma. Future studies may be enhanced by better assessment of the specific job exposures of cleaners and implementation of a prospective design. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - occupational hazards
KW - cleaning workers
KW - janitors
KW - health problems
KW - 2009
KW - Hazards
KW - Health
KW - Occupational Exposure
KW - Personnel
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US. Grant: T42/CCT422952. Recipients: No recipient indicated
U1 - Sponsor: UNC, Occupational Safety and Health Education and Research Center. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-04064-012&site=ehost-live&scope=site
UR - lcharles@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-04320-011
AN - 2009-04320-011
AU - Rice, Martin S.
AU - Woolley, Sandra M.
AU - Waters, Thomas R.
T1 - Comparison of required operating forces between floor-based and overhead-mounted patient lifting devices.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2009/01//
VL - 52
IS - 1
SP - 112
EP - 120
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Rice, Martin S.
N1 - Accession Number: 2009-04320-011. PMID: 19308824 Partial author list: First Author & Affiliation: Rice, Martin S.; Department of Occupational Therapy, University of Toledo, Toledo, OH, US. Release Date: 20090511. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; Motor Processes; Safety Devices; Client Transfer. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jan, 2009.
AB - This study investigated the differences in required push, pull and rotating forces for moving fully loaded, floor-based and overhead-mounted full body patient lifting devices with simulated patients of varying weight on a floor of optimal design (i.e. level vinyl tile over concrete). A single person operated the lifting devices for all of the tests. Eighteen male and female volunteer participants, ranging in weight from 51 to 146 kg, acted as patients during the lifting tests. For each test, the simulated patients were pushed and pulled for 3.7 linear metres and were rotated while sitting in the lift slings. Force measurements were acquired using two single axis dynamometers affixed to the lifting devices. Results revealed that, in general, operator input force and torque increased with patient weight category and floor-based lifts required greater force and torque compared to the overhead-mounted lift. Comparison of the required forces with published force limits reveals that the required push and pull force from the various patient lift systems, across all weight categories, were generally acceptable to 90% of the female population. The required forces for these patient transfer tasks, however, could exceed maximum acceptable force limits if the floor surfaces were less than ideal, such as floors composed of carpet, wood, or inclined surfaces. Additional research is needed to assess these conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - operating forces
KW - patient lifting devices
KW - body weight
KW - overhead-mounted lift
KW - floor-based lift
KW - patient transfer
KW - 2009
KW - Body Weight
KW - Motor Processes
KW - Safety Devices
KW - Client Transfer
KW - 2009
DO - 10.1080/00140130802481123
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-04320-011&site=ehost-live&scope=site
UR - Martin.Rice@utoledo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-19275-024
AN - 2008-19275-024
AU - Hughes, Jennifer M.
AU - Wirth, Oliver
AU - Krajnak, Kristine
AU - Miller, Roger
AU - Flavahan, Sheila
AU - Berkowitz, Dan E.
AU - Welcome, Dan
AU - Flavahan, Nicholas A.
T1 - Increased oxidant activity mediates vascular dysfunction in vibration injury.
JF - The Journal of Pharmacology and Experimental Therapeutics
JO - The Journal of Pharmacology and Experimental Therapeutics
JA - J Pharmacol Exp Ther
Y1 - 2009/01//
VL - 328
IS - 1
SP - 223
EP - 230
CY - US
PB - American Society for Pharmacology & Experimental Therapeutics ASPET
SN - 0022-3565
SN - 1521-0103
AD - Flavahan, Nicholas A., Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building, Room 370, 720 Rutland Ave., Baltimore, MD, US, 21205
N1 - Accession Number: 2008-19275-024. PMID: 18955588 Other Journal Title: Pharmacological Reviews. Partial author list: First Author & Affiliation: Hughes, Jennifer M.; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20090316. Correction Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Arteries (Anatomy); Oxygen; Vibration. Minor Descriptor: Rats. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jan, 2009.
AB - Occupational exposure to hand-operated vibrating tools causes a spectrum of pathological changes in the vascular, neurological, and musculoskeletal systems described as the hand-arm vibration syndrome (HAVS). Experiments were performed to determine the effects of acute vibration on the function of digital arteries. Rats paws were exposed to a vibrating platform (4 h, 125 Hz, constant acceleration of 49 m/s² root mean squared), and digital artery function was assessed subsequently in vitro using a pressure myograph system. Constriction to phenylephrine or 5-hydroxytryptamine was reduced in digital arteries from vibrated paws. However, after endothelium denudation, constriction to the agonists was no longer impaired in vibrated arteries. Inhibition of nitric-oxide synthase (NOS) with Nω-nitro-L-arginine methyl ester (L-NAME) increased constriction to phenylephrine or 5-hydroxytryptamine in vibrated but not control arteries and abolished the vibration-induced depression in constrictor responses. However, nitric oxide (NO) activity, determined using the NO-sensitive probe 4-amino-5-methylamino-2', 7'-difluorofluorescein, was reduced in vibrated compared with control arteries. Endogenous levels of reactive oxygen species (ROS), determined using the ROS-sensitive probe 5-(and 6)-chloromethyl-2',7'-dichlorodihydro-fluorescein, were increased in vibrated compared with control arteries. The increased ROS levels were abolished by L-NAME or by catalase, which degrades extracellular hydrogen peroxide. Catalase also increased constriction to phenylephrine or 5-hydroxytryptamine in vibrated but not control arteries and abolished the vibration-induced depression in constrictor responses. The results suggest that acute vibration causes vascular dysfunction in digital arteries by increasing ROS levels, which is probably mediated by uncoupling of endothelial NOS. Therefore, therapeutic strategies to inhibit ROS or augment NO activity may be beneficial in HAVS. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oxidant activity
KW - vascular dysfunction
KW - vibration injury
KW - digital arteries
KW - 2009
KW - Arteries (Anatomy)
KW - Oxygen
KW - Vibration
KW - Rats
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health, US. Grant: OH008531. Recipients: No recipient indicated
DO - 10.1124/jpet.108.144618
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-19275-024&site=ehost-live&scope=site
UR - nflavah1@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-12556-003
AN - 2010-12556-003
AU - Mohan, Ketha V. K.
AU - Zhang, Cheryl X.
AU - Atreya, Chintamani D.
T1 - The proteoglycan bamacan is a host cellular ligand of vaccinia virus neurovirulence factor N1L.
JF - Journal of Neurovirology
JO - Journal of Neurovirology
JA - J Neurovirol
Y1 - 2009///
VL - 15
IS - 3
SP - 229
EP - 237
CY - US
PB - Informa Healthcare
SN - 1355-0284
SN - 1538-2443
AD - Mohan, Ketha V. K., CBER, FDA, NIH Campus, Building 29A, Room 2C-15, HFM-335, 8800 Rockville Pike, Bethesda, MD, US, 20892
N1 - Accession Number: 2010-12556-003. PMID: 19444697 Partial author list: First Author & Affiliation: Mohan, Ketha V. K.; Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Food and Drug Administration, Bethesda, MD, US. Other Publishers: Springer; Taylor & Francis. Release Date: 20100802. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Immunization; Nervous System Disorders; Neural Receptors; Viral Disorders; Ligand. Minor Descriptor: Mice; Proteins. Classification: Neuropsychology & Neurology (2520); Neurological Disorders & Brain Damage (3297). Population: Human (10); Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: 2009. Publication History: First Posted Date: May 13, 2009; Accepted Date: Mar 5, 2009; Revised Date: Feb 24, 2009; First Submitted Date: Jan 27, 2009. Copyright Statement: Journal of NeuroVirology. 2009.
AB - Neurovirulence is one of the pathological complications associated with vaccinia virus (VV) infection/vaccination. Although the viral N1L protein has been identified as the neurovirulence factor, none of the host N1L-interacting factors have been identified so far. In the present study, we identified N1L-interacting proteins by screening a human brain cDNA expression library with N1L as a bait protein in a yeast two-hybrid analysis. The analysis revealed that N1L interacts with human brain-originated cellular basement membrane-associated chondroitin sulfate proteoglycan (bamacan). The N1L-binding domain of bamacan was mapped to its C-terminal 227 amino acids. The N1L-bamacan interaction was further confirmed in both VV-infected and N1L-transfected mammalian cells. Following the confirmation of the protein interactions by coimmunoprecipitation experiments, confocal microscopic analysis revealed that N1L colocalizes with bamacan both in VV-infected B-SC-1 cells as well as in mice neuronal tissue. Furthermore, a human neural cell line, which expresses bamacan to moderately elevated levels relative to a non-neural cell line, supported enhanced viral growth. Overall, these studies clearly suggest that bamacan interacts with the VV-N1L and such interactions seem to play a positive role in promoting the viral growth and perhaps contribute to the virulence of VV in neural cells. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - chondroitin sulfate proteoglycan
KW - host cellular ligands
KW - vaccinia virus
KW - neurovirulence factors
KW - vaccination
KW - mice
KW - bamacan
KW - 2009
KW - Immunization
KW - Nervous System Disorders
KW - Neural Receptors
KW - Viral Disorders
KW - Ligand
KW - Mice
KW - Proteins
KW - 2009
U1 - Sponsor: CBER. Recipients: No recipient indicated
U1 - Sponsor: Food and Drug Administration. Other Details: CounterTerrorism (CT). Recipients: No recipient indicated
DO - 10.1080/13550280902913636
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-12556-003&site=ehost-live&scope=site
UR - krishna.ketha391534@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-09286-013
AN - 2009-09286-013
AU - Gallagher, Sean
AU - Moore, Susan
AU - Dempsey, Patrick G.
T1 - An analysis of injury claims from low-seam coal mines.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2009///
VL - 40
IS - 3
SP - 233
EP - 237
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Gallagher, Sean, National Institute for Occupational Safety and Health, Mining Injury Prevention Branch, PO Box 18070, Pittsburgh, PA, US, 15236-0070
N1 - Accession Number: 2009-09286-013. PMID: 19527819 Partial author list: First Author & Affiliation: Gallagher, Sean; National Institute for Occupational Safety and Health, Mining Injury Prevention Branch, Pittsburgh, PA, US. Release Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Injuries; Posture. Minor Descriptor: Working Conditions. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: 2009.
AB - Introduction: The restricted workspace present in low-seam coal mines forces workers to adopt awkward working postures (kneeling and stooping), which place high physical demands on the knee and lower back. Method: This article provides an analysis of injury claims for eight mining companies operating low-seam coal mines during calendar years 1996-2008. All cost data were normalized using data on the cost of medical care (MPI) as provided by the U.S. Bureau of Labor Statistics. Results: Results of the analysis indicate that the knee was the body part that led in terms of claim cost ($4.2 million), followed by injuries to the lower back ($2.7 million). While the average cost per injury for these body parts was $13,100 and $14,400, respectively (close to the average cost of an injury overall), the high frequency of these injuries resulted in their pre-eminence in terms of cost. Analysis of data from individual mining companies suggest that knee and lower back injuries were a consistent problem across companies, as these injuries were each among the top five most costly part of body for seven out of eight companies studied. Application/Impact: Results of this investigation suggest that efforts to reduce the frequency of knee and low back injuries in low-seam mines have the potential to create substantial cost savings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - injury claims
KW - low seam coal mines
KW - working postures
KW - 2009
KW - Injuries
KW - Posture
KW - Working Conditions
KW - 2009
DO - 10.1016/j.jsr.2009.04.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-09286-013&site=ehost-live&scope=site
UR - sfg9@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17889-031
AN - 2008-17889-031
AU - Madras, Bertha K.
AU - Compton, Wilson M.
AU - Avula, Deepa
AU - Stegbauer, Tom
AU - Stein, Jack B.
AU - Clark, H. Westley
T1 - Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: Comparison at intake and 6 months later.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2009/01//
VL - 99
IS - 1-3
SP - 280
EP - 295
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Madras, Bertha K., Harvard Medical School-NEPRC, 1 Pine Hill Drive, Southborough, MA, US, 01772
N1 - Accession Number: 2008-17889-031. PMID: 18929451 Partial author list: First Author & Affiliation: Madras, Bertha K.; Harvard Medical School-NEPRC, Southborough, MA, US. Release Date: 20090427. Correction Date: 20140120. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: National Medical Education Conference, Jan, 2008, Washington, DC, US. Conference Note: Portions of this manuscript were presented at the aforementioned conference. Major Descriptor: Alcoholism; Drug Abuse; Drug Rehabilitation; Drug Usage Screening; Professional Referral. Minor Descriptor: Health Care Services. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: Health Lifeways Questionnaire; Depression Identification and Treatment Protocol; Car, Relax, Alone, Forget, Family, Friends or Trouble Instrument; Alcohol Use Disorders Identification Test DOI: 10.1037/t01528-000; CAGE Questionnaire DOI: 10.1037/t01522-000; Drug Abuse Screening Test DOI: 10.1037/t09815-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Jan, 2009.
AB - Objectives: Alcohol screening and brief interventions in medical settings can significantly reduce alcohol use. Corresponding data for illicit drug use is sparse. A Federally funded screening, brief interventions, referral to treatment (SBIRT) service program, the largest of its kind to date, was initiated by the Substance Abuse and Mental Health Services Administration (SAMHSA) in a wide variety of medical settings. We compared illicit drug use at intake and 6 months after drug screening and interventions were administered. Design: SBIRT services were implemented in a range of medical settings across six states. A diverse patient population (Alaska Natives, American Indians, African-Americans, Caucasians, Hispanics), was screened and offered score-based progressive levels of intervention (brief intervention, brief treatment, referral to specialty treatment). In this secondary analysis of the SBIRT service program, drug use data was compared at intake and at a 6-month follow-up, in a sample of a randomly selected population (10%) that screened positive at baseline. Results: Of 459,599 patients screened, 22.7% screened positive for a spectrum of use (risky/problematic, abuse/addiction). The majority were recommended for a brief intervention (15.9%), with a smaller percentage recommended for brief treatment (3.2%) or referral to specialty treatment (3.7%). Among those reporting baseline illicit drug use, rates of drug use at 6-month follow-up (4 of 6 sites), were 67.7% lower (p < 0.001) and heavy alcohol use was 38.6% lower (p < 0.001), with comparable findings across sites, gender, race/ethnic, age subgroups. Among persons recommended for brief treatment or referral to specialty treatment, self-reported improvements in general health (p < 0.001), mental health (p < 0.001), employment (p < 0.001), housing status (p < 0.001), and criminal behavior (p < 0.001) were found. Conclusions: SBIRT was feasible to implement and the self-reported patient status at 6 months indicated significant improvements over baseline, for illicit drug use and heavy alcohol use, with functional domains improved, across a range of health care settings and a range of patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol screening
KW - brief interventions
KW - referral to treatment
KW - illicit drug use
KW - alcohol use
KW - multiple healthcare sites
KW - 2009
KW - Alcoholism
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Drug Usage Screening
KW - Professional Referral
KW - Health Care Services
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Other Details: States and administered by the States. Recipients: No recipient indicated
DO - 10.1016/j.drugalcdep.2008.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17889-031&site=ehost-live&scope=site
UR - bertha_madras@hms.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2008-17889-039
AN - 2008-17889-039
AU - Mark, Tami L.
AU - Kassed, Cheryl A.
AU - Vandivort-Warren, Rita
AU - Levit, Katharine R.
AU - Kranzler, Henry R.
T1 - Alcohol and opioid dependence medications: Prescription trends, overall and by physician specialty.
JF - Drug and Alcohol Dependence
JO - Drug and Alcohol Dependence
JA - Drug Alcohol Depend
Y1 - 2009/01//
VL - 99
IS - 1-3
SP - 345
EP - 349
CY - Netherlands
PB - Elsevier Science
SN - 0376-8716
AD - Mark, Tami L., Thomson Healthcare, 4301 Connecticut Avenue, Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2008-17889-039. PMID: 18819759 Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Healthcare, Washington, DC, US. Release Date: 20090427. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alcoholism; Drug Dependency; Drug Therapy; Physicians; Prescribing (Drugs). Minor Descriptor: Opiates. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Jan, 2009.
AB - Over the past decade, advances in addiction neurobiology have led to the approval of new medications to treat alcohol and opioid dependence. This study examined data from the IMS National Prescription Audit (NPA) PlusTM database of retail pharmacy transactions to evaluate trends in U.S. retail sales and prescriptions of FDA-approved medications to treat substance use disorders. Data reveal that prescriptions for alcoholism medications grew from 393,000 in 2003 ($30 million in sales) to an estimated 720,000 ($78 million in sales) in 2007. The growth was largely driven by the introduction of acamprosate in 2005, which soon became the market leader ($35 million in sales). Prescriptions for the two buprenorphine formulations increased from 48,000 prescriptions ($5 million in sales) in the year of their introduction (2003) to 1.9 million prescriptions ($327 million in sales) in 2007. While acamprosate and buprenorphine grew rapidly after market entry, overall substance abuse retail medication sales remain small relative to the size of the population that could benefit from treatment and relative to sales for other medications, such as antidepressants. The extent to which substance dependence medications will be adopted by physicians and patients, and marketed by industry, remains uncertain. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - alcohol dependence
KW - opioid dependence
KW - medications
KW - prescription trends
KW - physician specialty
KW - 2009
KW - Alcoholism
KW - Drug Dependency
KW - Drug Therapy
KW - Physicians
KW - Prescribing (Drugs)
KW - Opiates
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration (SAMHSA). Recipients: No recipient indicated
DO - 10.1016/j.drugalcdep.2008.07.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2008-17889-039&site=ehost-live&scope=site
UR - Tami.mark@thomson.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-13343-004
AN - 2009-13343-004
AU - Wolff, Nancy
AU - Shi, Jing
AU - Siegel, Jane A.
T1 - Patterns of victimization among male and female inmates: Evidence of an enduring legacy.
JF - Violence and Victims
JO - Violence and Victims
JA - Violence Vict
Y1 - 2009///
VL - 24
IS - 4
SP - 469
EP - 484
CY - US
PB - Springer Publishing
SN - 0886-6708
AD - Wolff, Nancy, Center for Mental Health Services and Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2009-13343-004. PMID: 19694352 Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Child Abuse; Domestic Violence; Physical Abuse; Prisoners; Victimization. Minor Descriptor: Epidemiology; Sexual Abuse. Classification: Behavior Disorders & Antisocial Behavior (3230); Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: National Violence Against Women and Men Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: 2009.
AB - People inside prison have above-average rates of childhood and adult victimization. Little is known, however, about the relationship between types of victimization inside prison and that experienced in childhood. This article estimates rates of victimization for male and female inmates by type of perpetrator and form of victimization (sexual, physical, either, or both) and their association with types of childhood victimization (sexual or physical). Data for these estimates are based on a random sample of approximately 7,500 inmates housed in 12 adult male prisons and one adult female prison in a single state. The significance of the findings for practice are discussed along with recommendations to improve the health and welfare of people inside prison. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - inmates
KW - patterns of victimization
KW - childhood victimization
KW - adult victimization
KW - prevalence
KW - interpersonal violence
KW - abuse
KW - 2009
KW - Child Abuse
KW - Domestic Violence
KW - Physical Abuse
KW - Prisoners
KW - Victimization
KW - Epidemiology
KW - Sexual Abuse
KW - 2009
U1 - Sponsor: Office of Justice Programs. Grant: OJP-2004-RP-BX-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20 MH66170. Recipients: No recipient indicated
DO - 10.1891/0886-6708.24.4.469
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13343-004&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-26293-007
AN - 2010-26293-007
AU - Wolff, Nancy
AU - Shi, Jing
T1 - Feelings of safety inside prison among male inmates with different victimization experiences.
JF - Violence and Victims
JO - Violence and Victims
JA - Violence Vict
Y1 - 2009///
VL - 24
IS - 6
SP - 800
EP - 816
CY - US
PB - Springer Publishing
SN - 0886-6708
AD - Wolff, Nancy, Center for Mental Health Services & Criminal Justice Research, Rutgers University, 30 College Avenue, New Brunswick, NJ, US, 08901
N1 - Accession Number: 2010-26293-007. PMID: 20055216 Partial author list: First Author & Affiliation: Wolff, Nancy; Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, NJ, US. Release Date: 20110110. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Prisoners; Prisons; Safety; Victimization. Classification: Criminal Rehabilitation & Penology (3386). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Tests & Measures: National Violence Against Women and Men Survey. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: 2009. Copyright Statement: Springer Publishing Company. 2009.
AB - Correctional facilities have a responsibility to take 'reasonable measures' to preserve and protect inmate safety. The extent to which people inside prison feel safe from victimization is explored using a sample of approximately 7,000 adult male inmates housed in 13 prisons. The majority of male inmates reported no victimization in the past 6 months and that they felt safe, especially from sexual abuse and assault. Levels of feeling safe diminished for inmates who experienced victimization. Inmate perceptions of safety varied between facilities. Variation in perceptions of safety among harmful situations and between facilities provides useful information about inmate safety and ways to improve it. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - feelings of safety
KW - prison
KW - male inmates
KW - victimization
KW - 2009
KW - Prisoners
KW - Prisons
KW - Safety
KW - Victimization
KW - 2009
U1 - Sponsor: Office of Justice Programs. Grant: OJP-2004-RP-BX-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, US. Grant: P20 MH66170. Recipients: No recipient indicated
DO - 10.1891/0886-6708.24.6.800
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-26293-007&site=ehost-live&scope=site
UR - nwolff@ifh.rutgers.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-24731-017
AN - 2009-24731-017
AU - Jones, Wanda K.
T1 - EDICT policy recommendations support protection of research participants.
JF - Journal of Cancer Education
JO - Journal of Cancer Education
JA - J Cancer Educ
Y1 - 2009/01//
VL - 24
IS - Suppl 2
SP - S52
EP - S53
CY - United Kingdom
PB - Taylor & Francis
SN - 0885-8195
SN - 1543-0154
AD - Jones, Wanda K., Department of Health & Human Services, Office of Public Health & Science, 200 Independence Ave, Room 716G, Washington, DC, US, 20201
N1 - Accession Number: 2009-24731-017. PMID: 20024827 Partial author list: First Author & Affiliation: Jones, Wanda K.; Office of Public Health and Science, US Department of Health and Human Services, Washington, DC, US. Other Publishers: Lawrence Erlbaum; Springer. Release Date: 20100719. Correction Date: 20141103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Ethnic Identity; Experimental Ethics; Health Care Policy. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jan, 2009. Copyright Statement: AACE and EACE
AB - Ethical principles covering inclusion of participants in biomedical research include beneficence, respect for persons, and justice. Put simply, research aims to improve understanding or treatment of a health condition or disease and not make things worse, must attract participants completely free of coercion, and must be relevant to those bearing the burden of the health condition or disease. Despite this framework of protections, women and minorities continue to be underrepresented in clinical trials. Even if studies include proportional numbers, it is likely that the overall study size is insufficient to draw conclusions of relevance to the sex, gender, race/ethnicity, or age of participants. The potential for harm to populations underrepresented in research may not be revealed until a drug or device is on the market, accessible to larger numbers of people through routine medical practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care policy
KW - biomedical research participants
KW - ethnicity
KW - ethical principles
KW - 2009
KW - Ethnic Identity
KW - Experimental Ethics
KW - Health Care Policy
KW - 2009
DO - 10.1080/08858190903404510
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-24731-017&site=ehost-live&scope=site
UR - wanda.jones@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-24731-018
AN - 2009-24731-018
AU - Graham, Garth
AU - Heurtin-Roberts, Suzanne
T1 - Addressing disparities in clinical trials: Culturally and linguistically appropriate standards in clinical trials (CLAS-ACT) and the EDICT backpack initiative.
JF - Journal of Cancer Education
JO - Journal of Cancer Education
JA - J Cancer Educ
Y1 - 2009/01//
VL - 24
IS - Suppl 2
SP - S54
EP - S55
CY - United Kingdom
PB - Taylor & Francis
SN - 0885-8195
SN - 1543-0154
AD - Graham, Garth, Department of Health & Human Services, Office of Minority Health, 1101 Wootton Parkway, Suite 600, Washington, DC, US, 20852
N1 - Accession Number: 2009-24731-018. PMID: 20024828 Partial author list: First Author & Affiliation: Graham, Garth; Office of Minority Health, US Department of Health and Human Services, Washington, DC, US. Other Publishers: Lawrence Erlbaum; Springer. Release Date: 20100719. Correction Date: 20141103. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Ethnic Identity; Minority Groups; Health Disparities. Minor Descriptor: Linguistics. Classification: Professional Ethics & Standards & Liability (3450). Population: Human (10). References Available: Y. Page Count: 2. Issue Publication Date: Jan, 2009. Copyright Statement: AACE and EACE
AB - Limited participation of racial/ethnic minorities and other vulnerable populations in clinical trials is greatly troubling, because participation in clinical trials may result in benefits for participant populations. Research with a diverse study sample generates treatments demonstrated as safe and effective for a broad range of populations. Participation also gives access to potentially state-of-the-art medical care. It is widely known that a greater burden of disease and death falls on racial ethnic minorities and other vulnerable populations. The Eliminating Disparities in Clinical Trials (EDICT) project has been ambitious and sweeping in its efforts to eliminate disparities in clinical research. It has developed recommendations for policy, engaged in broad campaigns to inform the public, engaged in field research, and developed tools such as the BackPack and CLAS-ACT. EDICT has brought us closer to achieving the goal of equity in clinical trials. We look forward with our partners in EDICT to a future of fully researched treatments and cures made accessible to all of our population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health disparities
KW - clinical trials
KW - linguistics
KW - minority groups
KW - ethnicity
KW - 2009
KW - Clinical Trials
KW - Ethnic Identity
KW - Minority Groups
KW - Health Disparities
KW - Linguistics
KW - 2009
DO - 10.1080/08858190903404536
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-24731-018&site=ehost-live&scope=site
UR - garth.graham@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - BOOK
ID - 2009-04175-000
AN - 2009-04175-000
AU - McKeon, Richard T.
T1 - Suicidal behavior.
T3 - Advances in psychotherapy—evidence-based practice
Y1 - 2009///
CY - Ashland, OH, US
PB - Hogrefe & Huber Publishers
SN - 978-0-88937-327-3
N1 - Accession Number: 2009-04175-000. Partial author list: First Author & Affiliation: McKeon, Richard T.; Substance Abuse and Mental Health Services Administration, US. Release Date: 20090511. Publication Type: Book (0200), Authored Book (0240). Format Covered: Print. ISBN: 978-0-88937-327-3, Paperback. Language: English. Major Descriptor: Attempted Suicide; Suicide; Treatment Planning; Treatment; Risk Assessment. Minor Descriptor: Psychological Theories. Classification: Behavior Disorders & Antisocial Behavior (3230); Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Intended Audience: Psychology: Professional & Research (PS). References Available: Y. Page Count: 100.
AB - Over 30,000 Americans and almost one million persons worldwide die by suicide each year, making it one of the leading causes of death throughout the lifespan. Suicide attempts outnumber deaths by suicide by a ratio of at least 25 to 1 And those who attempt suicide are at high risk of later death by suicide or of additional suicide attempts. Suicide risk is one ofthe most frequent reasons for admissions to inpatient psychiatric units. All of these facts make the treatment of those at risk for suicide a pressing priority. Research over the past two decades has led to the development of excellent empirically supported treatment methods. This book aims to increase clinicians' access to empirically supported interventions for suicidal behavior, with the hope that these methods will become the standard in clinical practice. Sections of the book include (1) theories and models of suicidal behavior, (2) risk assessment and treatment planning, and (3) treatment. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicidal behavior
KW - theories & models
KW - suicide attempts
KW - risk assessment
KW - treatment planning
KW - treatment
KW - 2009
KW - Attempted Suicide
KW - Suicide
KW - Treatment Planning
KW - Treatment
KW - Risk Assessment
KW - Psychological Theories
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-04175-000&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Funnell, Martha M.
AU - Brown, Tammy L.
AU - Childs, Belinda P.
AU - Haas, Linda B.
AU - Hosey, Gwen M.
AU - Jensen, Brian
AU - Maryniuk, Melinda
AU - Peyrot, Mark
AU - Piette, John N.
AU - Reader, Diane
AU - Siminerio, Linda M.
AU - Weinger, Katie
AU - Weiss, Michael A.
T1 - National Standards for Diabetes Self-Management Education.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2009/01/02/Jan2009 Supplement 1
VL - 32
M3 - Article
SP - S87
EP - S94
SN - 01495992
AB - The article reports on the national standards for diabetes self-management education (DSME) in the U.S. It is noted that DSME is the ongoing process of facilitating the knowledge, skill, and ability necessary for diabetes self-care. This process incorporates the needs, goals, and life experiences of the person with diabetes and is guided by evidence-based standards.
KW - HEALTH self-care
KW - DIABETES -- Treatment
KW - PREVENTIVE health services
KW - DIABETICS
KW - MEDICAL care
KW - UNITED States
N1 - Accession Number: 36278047; Funnell, Martha M. 1; Email Address: mfunnell@umich.edu Brown, Tammy L. 2 Childs, Belinda P. 3 Haas, Linda B. 4 Hosey, Gwen M. 5 Jensen, Brian 6 Maryniuk, Melinda 7 Peyrot, Mark 8 Piette, John N. 9,10 Reader, Diane 11 Siminerio, Linda M. 12 Weinger, Katie 7 Weiss, Michael A. 13; Affiliation: 1: Department of Medical Education, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 2: Indian Health Service, Albuquerque, New Mexico 3: MidAmerica Diabetes Associates, Wichita, Kansas 4: VA Puget Sound Health Care System, Seattle, Washington 5: Division of Diabetes Translation, National Center for Chronic Diseases Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 6: Lakeshore Apothacare, Two Rivers, Wisconsin 7: Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 8: Loyola College, Baltimore, Maryland 9: VA Ann Arbor Health Care System, Ann Arbor, Michigan 10: Department of Internal Medicine, Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan 11: International Diabetes Center, Minneapolis, Minnesota 12: Diabetes Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 13: Patient Centered Solutions, Pittsburgh, Pennsylvania; Source Info: Jan2009 Supplement 1, Vol. 32, pS87; Subject Term: HEALTH self-care; Subject Term: DIABETES -- Treatment; Subject Term: PREVENTIVE health services; Subject Term: DIABETICS; Subject Term: MEDICAL care; Subject Term: UNITED States; Number of Pages: 8p; Document Type: Article; Full Text Word Count: 7779
L3 - 10.2337/dc09-S087
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36278047&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kowalski-Trakofler, K. M.
AU - Alexander, D. W.
AU - Brnich Jr., M. J.
AU - McWilliams, L. J.
AU - Reisman, D. B.
T1 - Underground Coal Mining Disasters and Fatalities -- United States, 1900-2006.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2009/01/02/
VL - 57
IS - 51/52
M3 - Article
SP - 1379
EP - 1407
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - This article discusses the incidents of underground coal mining accidents and fatalities in the U.S. from 1900 to 2006. It says that during a five-month period in 2006, three underground coal mining incidents in the country were reported by the media. Records reveal that mining accidents had decreased from a high of 20 in 1909 to an everage of one every four years during 1985-2005. To address the safety problem the Mine Improvement and New Emergency Response Act of 2006 was enacted.
KW - COAL mines & mining
KW - OCCUPATIONAL hazards
KW - WORK-related injuries
KW - INDUSTRIAL safety
KW - UNITED States
N1 - Accession Number: 36153801; Kowalski-Trakofler, K. M. 1 Alexander, D. W. 1 Brnich Jr., M. J. 1 McWilliams, L. J. 1 Reisman, D. B. 2; Affiliation: 1: Office of Mine Safety and Health Research, Pittsburgh Research Laboratory 2: Office of the Director, National Institute for Occupational Safety and Health, CDC; Source Info: 1/2/2009, Vol. 57 Issue 51/52, p1379; Subject Term: COAL mines & mining; Subject Term: OCCUPATIONAL hazards; Subject Term: WORK-related injuries; Subject Term: INDUSTRIAL safety; Subject Term: UNITED States; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); Number of Pages: 29p; Illustrations: 8 Charts, 3 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36153801&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Jasseron, Carine
AU - Mandelbrot, Laurent
AU - Blanche, Stéphane
AU - Tubiana, Roland
AU - Le chenadec, Jérôme
AU - Teglas, Jean-Paul
AU - Dolfus, Catherine
AU - Faye, Albert
AU - Rouzioux, Christine
AU - Warszawski, Josiane
T1 - Is marital status and information of the father associated with access to prevention of mother-to-child HIV transmission?
JO - Retrovirology
JF - Retrovirology
Y1 - 2009/01/02/2009 Supplement 1
VL - 6
M3 - Abstract
SP - 1
EP - 2
PB - BioMed Central
SN - 17424690
AB - An abstract of the article "Is marital status and information of the father associated with access to prevention of mother-to-child HIV transmission?" by Carine Jasseron and colleagues, is presented.
KW - AIDS (Disease) -- Prevention
KW - ABSTRACTS
N1 - Accession Number: 43819490; Jasseron, Carine 1,2 Mandelbrot, Laurent 3,4 Blanche, Stéphane 5,6 Tubiana, Roland 7,8 Le chenadec, Jérôme 1,9 Teglas, Jean-Paul 1,9 Dolfus, Catherine 10 Faye, Albert 11 Rouzioux, Christine 5,12 Warszawski, Josiane 1,13; Affiliation: 1: Inserm U822, Le kremlin-Bicêtre, France. 2: AP-HP, Hôpital Bicêtre, Epidemiologie and public health service, Le kremlin-Bicêtre, France. 3: AP-HP, Hôpital Louis Mourrier, Gynecology and obstetrics department, Colombes, France. 4: Univ Paris 7, Paris, France. 5: EA 3620, Univ Paris Descartes 5, Paris, France. 6: AP-HP, Hôpital Necker, Unité d'immunologie Hématologie pédiatrique, Paris, France. 7: AP-HP, Hôpital Salpêtrière, Department of infectious diseases, Paris, France. 8: INSERM, U543, Paris, France. 9: INED, Paris, France. 10: AP-HP, Hôpital Trousseau, Service d'Hématologie et d'oncologie pédiatrique, Paris, France. 11: AP-HP, Hôpital Robert Debré, Service de pédiatrique générale, Paris, France. 12: AP-HP, Hôpital Necker, Virology Department, Paris, France. 13: Univ Paris sud, Faculté de médecine Paris Sud, Le kremlin-Bicêtre, France.; Source Info: 2009 Supplement 1, Vol. 6, p1; Subject Term: AIDS (Disease) -- Prevention; Subject Term: ABSTRACTS; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1186/1742-4690-6-S1-O20
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43819490&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Bushel, Pierre R.
AU - Nielsen, Dahlia
AU - Tong, Weida
T1 - Proceedings of the First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007).
JO - BMC Proceedings
JF - BMC Proceedings
Y1 - 2009/01/03/2009 Supplement 2
VL - 3
M3 - Proceeding
SP - 1
EP - 4
SN - 17536561
AB - The First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007) was held at the North Carolina State University McKimmon Center in Raleigh, North Carolina on October 25th and 26th, 2007. Based on the presentations at the conference and the commitment or interest of the presenters to contribute a manuscript of their research, we compiled this collection of articles as proceedings of the conference and an in-depth topical review of the utility of bioinformatics in the fields of toxicogenomics and environmental genomics. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Proceedings is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFERENCES & conventions
KW - GENOMICS -- Congresses
KW - TOXICOGENOMICS
KW - ENVIRONMENTAL sciences
KW - BIOINFORMATICS
KW - NORTH Carolina
N1 - Accession Number: 42513467; Bushel, Pierre R. 1; Email Address: bushel@niehs.nih.gov Nielsen, Dahlia 2,3; Email Address: dahlia@statgen.ncsu.edu Tong, Weida 4; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. 2: Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA. 3: Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA. 4: Center for Toxicoinformatics, National Center for Toxicological Research, Jefferson, Arkansas, USA.; Source Info: 2009 Supplement 2, Vol. 3, p1; Subject Term: CONFERENCES & conventions; Subject Term: GENOMICS -- Congresses; Subject Term: TOXICOGENOMICS; Subject Term: ENVIRONMENTAL sciences; Subject Term: BIOINFORMATICS; Subject Term: NORTH Carolina; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Document Type: Proceeding
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42513467&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Minjun Chen
AU - Martin, Jackson
AU - Hong Fang
AU - Isukapalli, Sastry
AU - Georgopoulos, Panos G.
AU - Welsh, William J.
AU - Weida Tong
T1 - ebTrack: an environmental bioinformatics system built upon ArrayTrack.
JO - BMC Proceedings
JF - BMC Proceedings
Y1 - 2009/01/03/2009 Supplement 2
VL - 3
M3 - Article
SP - 1
EP - 5
SN - 17536561
AB - ebTrack is being developed as an integrated bioinformatics system for environmental research and analysis by addressing the issues of integration, curation, management, first level analysis and interpretation of environmental and toxicological data from diverse sources. It is based on enhancements to the US FDA developed ArrayTrack™ system through additional analysis modules for gene expression data as well as through incorporation and linkages to modules for analysis of proteomic and metabonomic datasets that include tandem mass spectra. ebTrack uses a clientserver architecture with the free and open source PostgreSQL as its database engine, and java tools for user interface, analysis, visualization, and web-based deployment. Several predictive tools that are critical for environmental health research are currently supported in ebTrack, including Significance Analysis of Microarray (SAM). Furthermore, new tools are under continuous integration, and interfaces to environmental health risk analysis tools are being developed in order to make ebTrack widely usable. These health risk analysis tools include the Modeling ENvironment for TOtal Risk studies (MENTOR) for source-to-dose exposure modeling and the DOse Response Information ANalysis system (DORIAN) for health outcome modeling. The design of ebTrack is presented in detail and steps involved in its application are summarized through an illustrative application. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Proceedings is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENVIRONMENTAL research
KW - TOXICOLOGY
KW - GENE expression
KW - BIOINFORMATICS
KW - PROTEOMICS
KW - ENVIRONMENTAL health
KW - HEALTH risk assessment
KW - TOXICOGENOMICS
N1 - Accession Number: 42513471; Minjun Chen 1,2; Email Address: minjun.chen@fda.hhs.gov Martin, Jackson 3; Email Address: martin.jackson@fda.hhs.gov Hong Fang 3; Email Address: Hong.fang@fda.hhs.gov Isukapalli, Sastry 1; Email Address: sastry@turandot.rutgers.edu Georgopoulos, Panos G. 1; Email Address: panosg@fidelio.rutgers.edu Welsh, William J. 2; Email Address: welshwj@umdnj.edu Weida Tong 3; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: Department of Environmental and Occupational Medicine, UMDNJ-RWJMS, 675 Hoes Lane, Piscataway, NJ 08854, USA. 2: Department of Pharmacology, UMDNJ-RWJMS, 675 Hoes Lane, Piscataway, NJ 08854, USA. 3: Z-Tech Corporation, an ICF International Company, National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Road, HFT 230, Jefferson, AR 72079, USA.; Source Info: 2009 Supplement 2, Vol. 3, p1; Subject Term: ENVIRONMENTAL research; Subject Term: TOXICOLOGY; Subject Term: GENE expression; Subject Term: BIOINFORMATICS; Subject Term: PROTEOMICS; Subject Term: ENVIRONMENTAL health; Subject Term: HEALTH risk assessment; Subject Term: TOXICOGENOMICS; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 5p; Illustrations: 1 Diagram; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42513471&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaohui Fan
AU - Leming Shi
AU - Hong Fang
AU - Harris, Stephen
AU - Perkins, Roger
AU - Weida Tong
T1 - Investigation of reproducibility of differentially expressed genes in DNA microarrays through statistical simulation.
JO - BMC Proceedings
JF - BMC Proceedings
Y1 - 2009/01/03/2009 Supplement 2
VL - 3
M3 - Article
SP - 1
EP - 5
SN - 17536561
AB - Recent publications have raised concerns about the reliability of microarray technology because of the lack of reproducibility of differentially expressed genes (DEGs) from highly similar studies across laboratories and platforms. The rat toxicogenomics study of the MicroArray Quality Control (MAQC) project empirically revealed that the DEGs selected using a fold change (FC)- based criterion were more reproducible than those derived solely by statistical significance such as P-value from a simple t-tests. In this study, we generate a set of simulated microarray datasets to compare gene selection/ranking rules, including P-value, FC and their combinations, using the percentage of overlapping genes between DEGs from two similar simulated datasets as the measure of reproducibility. The results are supportive of the MAQC's conclusion on that DEG lists are more reproducible across laboratories and platforms when FC-based ranking coupled with a nonstringent P-value cutoff is used for gene selection compared with selection based on P-value based ranking method. We conclude that the MAQC recommendation should be considered when reproducibility is an important study objective. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Proceedings is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - SIMULATION methods & models
KW - TOXICOGENOMICS
KW - DNA microarrays
KW - GENOMICS
KW - QUANTITATIVE research
KW - GENES
N1 - Accession Number: 42513470; Xiaohui Fan 1,2; Email Address: fanxh@zju.edu.cn Leming Shi 1; Email Address: Leming.Shi@fda.hhs.gov Hong Fang 3; Email Address: Hong.Fang@fda.hhs.gov Harris, Stephen 1; Email Address: Steve.Harris@fda.hhs.gov Perkins, Roger 3; Email Address: Roger.Perkins@fda.hhs.gov Weida Tong 1; Email Address: Weida.Tong@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. 2: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, PR China. 3: Z-tech Corporation, an ICF International, National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA.; Source Info: 2009 Supplement 2, Vol. 3, p1; Subject Term: GENE expression; Subject Term: SIMULATION methods & models; Subject Term: TOXICOGENOMICS; Subject Term: DNA microarrays; Subject Term: GENOMICS; Subject Term: QUANTITATIVE research; Subject Term: GENES; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105290945
T1 - EDICT policy recommendations support protection of research participants...Eleventh Biennial Symposium on Minorities, the Medically Underserved, and Cancer in Washington, D.C., April 2008...Eliminating Disparities in Clinical Trials
AU - Jones WK
Y1 - 2009/01/03/2009 Supplement 2
N1 - Accession Number: 105290945. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2009 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 8610343.
KW - Health Policy
KW - Minority Groups
KW - Research Ethics
KW - Research Subjects
KW - Research, Medical
KW - Female
KW - Male
KW - Research Subject Recruitment
KW - United States
SP - S52
EP - 3
JO - Journal of Cancer Education
JF - Journal of Cancer Education
JA - J CANCER EDUC
VL - 24
CY - ,
PB - Springer Science & Business Media B.V.
SN - 0885-8195
AD - Department of Health & Human Services, Office of Public Health & Science, 200 Independence Ave., Room 716G, Washington, DC 20201; wanda.jones@hhs.gov
U2 - PMID: 20024827.
DO - 10.1080/08858190903404510
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290945&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290944
T1 - Addressing disparities in clinical trials: culturally and linguistically appropriate standards in clinical trials (CLAS-ACT) and the EDICT BackPack initiative...Eleventh Biennial Symposium on Minorities, the Medically Underserved, and Cancer in Washington, D.C., April 2008...Eliminating Disparities in Clinical Trials
AU - Graham G
AU - Heurtin-Roberts S
Y1 - 2009/01/03/2009 Supplement 2
N1 - Accession Number: 105290944. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2009 Supplement 2. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 8610343.
KW - Clinical Trials
KW - Health Services Accessibility
KW - Minority Groups
KW - Research Ethics
KW - Research Subject Recruitment
KW - Research Subjects
KW - Ethnic Groups
KW - Government Agencies
KW - United States
SP - S54
EP - 5
JO - Journal of Cancer Education
JF - Journal of Cancer Education
JA - J CANCER EDUC
VL - 24
CY - ,
PB - Springer Science & Business Media B.V.
SN - 0885-8195
AD - Office of Minority Health, US Department of Health and Human Services, 1101 Wootton Parkway, Suite 600, Washington, DC 20852; garth.graham@hhs.gov
U2 - PMID: 20024828.
DO - 10.1080/08858190903404536
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290944&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Changwon Keum
AU - Jung Hoon Woo
AU - Won Seok Oh
AU - Sue-Nie Park
AU - Kyoung Tai No
T1 - Improving gene expression similarity measurement using pathway-based analytic dimension.
JO - BMC Genomics
JF - BMC Genomics
Y1 - 2009/01/04/2009 Supplement 3
VL - 10
M3 - Article
SP - 1
EP - 6
PB - BioMed Central
SN - 14712164
AB - Background: Gene expression similarity measuring methods were developed and applied to search rapidly growing public microarray databases. However, current expression similarity measuring methods need to be improved to accurately measure similarity between gene expression profiles from different platforms or different experiments. Results: We devised new gene expression similarity measuring method based on pathway information. In short, newly devised method measure similarity between gene expression profiles after converting them into pathway based expression profiles. To evaluate pathway based gene expression similarity measuring method, we conducted cell type classification test. Pathway based similarity measuring method shows higher classification accuracy. Especially, pathway based methods outperform at most 50% and 10% over conventional gene expression similarity method when search databases are limited to cross-platform profiles and cross-experiment profiles. Conclusion: The pathway based gene expression similarity measuring method outperforms commonly used similarity measuring methods. Considering the fact that public microarray database is consist of gene expression profiles of various experiments with various type of platform, pathway based gene expression similarity measuring method could be successfully applied for searching large public microarray databases. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Genomics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - DNA microarrays
KW - GENETIC regulation
KW - CELLULAR control mechanisms
KW - DATABASES
N1 - Accession Number: 47371699; Changwon Keum 1; Email Address: cwkeum@gmail.com Jung Hoon Woo 2; Email Address: hydepark83@gmail.com Won Seok Oh 1; Email Address: wsoh@bmdrc.org Sue-Nie Park 3; Email Address: suenie@kfda.go.kr Kyoung Tai No 1,4; Email Address: ktno@bmdrc.org; Affiliation: 1: Bioinformatics & Molecular Design Research Center (BMDRC), Seoul, Korea 2: Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul, Korea 3: Division of Genetic Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea 4: Dept. of Biotechnology, Yonsei University, Seoul, Korea; Source Info: 2009 Supplement 3, Vol. 10, Special section p1; Subject Term: GENE expression; Subject Term: DNA microarrays; Subject Term: GENETIC regulation; Subject Term: CELLULAR control mechanisms; Subject Term: DATABASES; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1186/1471-2164-10-S3-S15
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47371699&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Vena, John E.
AU - Ambrosone, Christine B.
AU - Kadlubar, Fred F.
T1 - THE AUTHORS REPLY.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/01/06/
VL - 149
IS - 11
M3 - Letter
SP - 1072
EP - 1073
SN - 00029262
KW - LETTERS to the editor
KW - EPIDEMIOLOGY
KW - SUSSER, Ezra
N1 - Accession Number: 82423421; Vena, John E. 1,2 Ambrosone, Christine B. 3 Kadlubar, Fred F. 3; Affiliation: 1: Department of Social and Preventive Medicine State University of New York at Buffalo Buffalo, NY 14214-3000 2: Department of Biostatistics and Epidemiology University of Massachusetts at Amherst Amherst, MA 01003-0430 3: Division of Molecular Epidemiology National Center for Toxicological Research Jefferson, AR 72079; Source Info: 1999, Vol. 149 Issue 11, p1072; Subject Term: LETTERS to the editor; Subject Term: EPIDEMIOLOGY; People: SUSSER, Ezra; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Niu, Manette T.
AU - Ball, Robert
AU - Woo, Emily Jane
AU - Burwen, Dale R.
AU - Knippen, Maureen
AU - Braun, M. Miles
T1 - Adverse events after anthrax vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990–2007
JO - Vaccine
JF - Vaccine
Y1 - 2009/01/07/
VL - 27
IS - 2
M3 - Article
SP - 290
EP - 297
SN - 0264410X
AB - Abstract: During the period March 1, 1998 to January 14, 2007, approximately 6 million doses of Anthrax vaccine adsorbed (AVA) vaccine were administered. As of January 16, 2007, 4753 reports of adverse events following receipt of AVA vaccination had been submitted to the Vaccine Adverse Event Reporting System (VAERS). Taken together, reports to VAERS did not definitively link any serious unexpected risk to this vaccine, and review of death and serious reports did not show a distinctive pattern indicative of a causal relationship to AVA vaccination. Continued monitoring of VAERS and analysis of potential associations between AVA vaccination and rare, serious events is warranted. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Communicable diseases -- Prevention
KW - Anthrax
KW - Adverse health care events
KW - Vaccination centers
KW - COMPLICATIONS
KW - Public health -- United States
KW - Bacterial diseases
KW - United States
KW - Anthrax vaccine
KW - Post-marketing surveillance
KW - VAERS
N1 - Accession Number: 35659730; Niu, Manette T. 1; Email Address: manette.niu@fda.hhs.gov; Ball, Robert 1; Woo, Emily Jane 1; Burwen, Dale R. 1; Knippen, Maureen 2; Braun, M. Miles 1; Affiliations: 1: Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Division of Epidemiology, Vaccine Safety Branch, 1401 Rockville Pike, HFM-220, Rockville, MD 20852, United States; 2: Office of Compliance and Biologic Quality+, 1401 Rockville Pike, HFM-220, Rockville, MD 20852, United States; Issue Info: Jan2009, Vol. 27 Issue 2, p290; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Thesaurus Term: Communicable diseases -- Prevention; Subject Term: Anthrax; Subject Term: Adverse health care events; Subject Term: Vaccination centers; Subject Term: COMPLICATIONS; Subject Term: Public health -- United States; Subject Term: Bacterial diseases; Subject: United States; Author-Supplied Keyword: Anthrax vaccine; Author-Supplied Keyword: Post-marketing surveillance; Author-Supplied Keyword: VAERS; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.10.044
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35659730&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Li, Zhiguang
AU - Su, Zhenqiang
AU - Wen, Zhining
AU - Shi, Leming
AU - Chen, Tao
T1 - Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles.
JO - BMC Bioinformatics
JF - BMC Bioinformatics
Y1 - 2009/01/12/2009 Supplement 11
VL - 10
M3 - Article
SP - 1
EP - 8
PB - BioMed Central
SN - 14712105
AB - Background: Several different microarray platforms are available for measuring gene expression. There are disagreements within the microarray scientific community for intra- and inter-platform consistency of these platforms. Both high and low consistencies were demonstrated across different platforms in terms of genes with significantly differential expression. Array studies for gene expression are used to explore biological causes and effects. Therefore, consistency should eventually be evaluated in a biological setting to reveal the functional differences between the examined samples, not just a list of differentially expressed genes (DEG). In this study, we investigated whether different platforms had a high consistency from the biologically functional perspective. Results: DEG data without filtering the different probes in microarrays from different platforms generated from kidney samples of rats treated with the kidney carcinogen, aristolochic acid, in five test sites using microarrays from Affymetrix, Applied Biosystems, Agilent, and GE health platforms (two sites using Affymetrix for intra-platform comparison) were input into the Ingenuity Pathway Analysis (IPA) system for functional analysis. The functions of the DEG lists determined by IPA were compared across the four different platforms and two test sites for Affymetrix platform. Analysis results showed that there is a very high level of consistency between the two test sites using the same platform or among different platforms. The top functions determined by the different platforms were very similar and reflected carcinogenicity and toxicity of aristolochic acid in the rat kidney. Conclusion: Our results demonstrate that highly consistent biological information can be generated from different microarray platforms. [ABSTRACT FROM AUTHOR]
AB - Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA microarrays
KW - FUNCTIONAL analysis
KW - GENE expression
KW - CARCINOGENICITY
KW - RATS as laboratory animals
N1 - Accession Number: 45226105; Li, Zhiguang 1; Email Address: zhiguang.li@fda.hhs.gov Su, Zhenqiang 2; Email Address: zhenqiang.su@fda.hhs.gov Wen, Zhining 2; Email Address: zhining.wen@fda.hhs.gov Shi, Leming 2; Email Address: leming.shi@fda.hhs.gov Chen, Tao 1; Email Address: tao.chen@fda.hhs.gov; Affiliation: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA 2: Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, Arkansas 72079, USA; Source Info: 2009 Supplement 11, Vol. 10, Special section p1; Subject Term: DNA microarrays; Subject Term: FUNCTIONAL analysis; Subject Term: GENE expression; Subject Term: CARCINOGENICITY; Subject Term: RATS as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1186/1471-2105-10-S11-S12
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aaron Erdely
AU - Tracy Hulderman
AU - Rebecca Salmen
AU - Angie Liston
AU - Patti C. Zeidler-Erdely
AU - Diane Schwegler-Berry
AU - Vincent Castranova
AU - Shozo Koyama
AU - Yoong-Ahm Kim
AU - Morinobu Endo
AU - Petia P. Simeonova
T1 - Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers.
JO - Nano Letters
JF - Nano Letters
Y1 - 2009/01/14/
VL - 9
IS - 1
M3 - Article
SP - 36
EP - 43
SN - 15306984
AB - Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nano Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON nanotubes
KW - POISONOUS gases -- Toxicology
KW - NANOTECHNOLOGY
KW - HEALTH risk assessment
KW - BIOCHEMICAL markers
KW - NANOPARTICLES
N1 - Accession Number: 36166975; Aaron Erdely 1 Tracy Hulderman 1 Rebecca Salmen 1 Angie Liston 1 Patti C. Zeidler-Erdely 1 Diane Schwegler-Berry 1 Vincent Castranova 1 Shozo Koyama 1 Yoong-Ahm Kim 1 Morinobu Endo 1 Petia P. Simeonova 1; Affiliation: 1: Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and and Faculty of Engineering, Shinshu University, Nagano 380-8553, Japan; Source Info: Jan2009, Vol. 9 Issue 1, p36; Subject Term: CARBON nanotubes; Subject Term: POISONOUS gases -- Toxicology; Subject Term: NANOTECHNOLOGY; Subject Term: HEALTH risk assessment; Subject Term: BIOCHEMICAL markers; Subject Term: NANOPARTICLES; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105636936
T1 - Screening for carotid artery stenosis.
AU - Wolff T
Y1 - 2009/01/15/
N1 - Accession Number: 105636936. Language: English. Entry Date: 20090306. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Carotid Stenosis -- Diagnosis
KW - Male
KW - Middle Age
SP - 95
EP - 96
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 2
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19178060.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Li, Hui
AU - Smith, Michelle L.
AU - Chiesa, O. Alberto
AU - Kijak, Philip J.
T1 - Determination of sulfadimethoxine and 4 N-acetylsulfadimethoxine in bovine plasma, urine, oral fluid, and kidney and liver biopsy samples obtained surgically from standing animals by LC/MS/MS
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/01/15/
VL - 877
IS - 3
M3 - Article
SP - 237
EP - 246
SN - 15700232
AB - Abstract: A quantitative method was developed and validated to measure the concentration of sulfadimethoxine (SDM) and its major metabolite, 4 N-acetylsulfadimethoxine (AcSDM), in bovine tissues and body fluids. Liquid chromatography/tandem mass spectrometry (LC/MS/MS) gave quantitative results for these two analytes in extracts from bovine plasma, urine, oral fluid, kidney, and liver, using SDM-d4 as internal standard (I.S.). The lower limit of quantitation (LLOQ) for both analytes in these matrices was validated at 2, 100, and 5ng/mL in plasma, urine, and oral fluid respectively, and 10ng/g in both kidney (cortex) and liver. The overall accuracy (average of 4 levels) is, for plasma, 104% (SDM) and 95% (AcSDM), with standard deviation of 9% (SDM) and 15% (AcSDM); for urine, 100% (SDM) and 106% (AcSDM), with standard deviation of 5% (SDM) and 6% (AcSDM); for oral fluid, 103% (SDM) and 103% (AcSDM), with standard deviation of 4% (SDM) and 4% (AcSDM); for kidney, 101% (SDM) and 111% (AcSDM), with standard deviation of 7% (SDM) and 6% (AcSDM); and for liver, 99% (SDM) and 115% (AcSDM), with standard deviation of 11% (SDM) and 9% (AcSDM). C18 SPE cartridges were used to clean-up these matrices, except for urine which was diluted directly with buffer before analysis by LC/MS/MS. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIBACTERIAL agents
KW - TANDEM mass spectrometry
KW - LIQUID chromatography
KW - BODY fluids
KW - STANDARD deviations
KW - VETERINARY drug residues
KW - BLOOD plasma
KW - CATTLE -- Physiology
KW - 4 N-acetylsulfadimethoxine
KW - Bovine
KW - Kidney
KW - Liquid chromatography/tandem mass spectrometry
KW - Liver
KW - Oral fluid
KW - Plasma
KW - Quantitation
KW - Sulfadimethoxine
KW - Urine
KW - Veterinary drug residue
N1 - Accession Number: 36016696; Li, Hui; Email Address: hui.li@fda.hhs.gov Smith, Michelle L. 1 Chiesa, O. Alberto Kijak, Philip J. 1; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Jan2009, Vol. 877 Issue 3, p237; Subject Term: ANTIBACTERIAL agents; Subject Term: TANDEM mass spectrometry; Subject Term: LIQUID chromatography; Subject Term: BODY fluids; Subject Term: STANDARD deviations; Subject Term: VETERINARY drug residues; Subject Term: BLOOD plasma; Subject Term: CATTLE -- Physiology; Author-Supplied Keyword: 4 N-acetylsulfadimethoxine; Author-Supplied Keyword: Bovine; Author-Supplied Keyword: Kidney; Author-Supplied Keyword: Liquid chromatography/tandem mass spectrometry; Author-Supplied Keyword: Liver; Author-Supplied Keyword: Oral fluid; Author-Supplied Keyword: Plasma; Author-Supplied Keyword: Quantitation; Author-Supplied Keyword: Sulfadimethoxine; Author-Supplied Keyword: Urine; Author-Supplied Keyword: Veterinary drug residue; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112112 Cattle Feedlots; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jchromb.2008.12.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36016696&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sulub, Yusuf
AU - Wabuyele, Busolo
AU - Gargiulo, Paul
AU - Pazdan, James
AU - Cheney, James
AU - Berry, Joseph
AU - Gupta, Abhay
AU - Shah, Rakhi
AU - Wu, Huiquan
AU - Khan, Mansoor
T1 - Real-time on-line blend uniformity monitoring using near-infrared reflectance spectrometry: A noninvasive off-line calibration approach
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2009/01/15/
VL - 49
IS - 1
M3 - Article
SP - 48
EP - 54
SN - 07317085
AB - Abstract: A robust, noninvasive, real-time, on-line near-infrared (NIR) quantitative method is described for blend uniformity monitoring of a pharmaceutical solid dosage form containing 29.4% (w/w) drug load with three major excipients (crospovidone, lactose, and microcrystalline cellulose). A set of 21 off-line, static calibration samples were used to develop a multivariate partial least-squares (PLS) calibration model for on-line prediction of the API content during the blending process. The concentrations of the API and the three major excipients were varied randomly to minimize correlations between the components. A micro electrical-mechanical system (MEMS) based portable, battery operated NIR spectrometer was used for this study. To minimize spectral differences between the static and dynamic measurement modes, the acquired NIR spectra were preprocessed using standard normal variate (SNV) followed by second derivative Savitzky-Golay using 21 points. The performance of the off-line PLS calibration model were evaluated in real-time on 16 laboratory scale (30L bin size) blend experiments conducted over 3 months. To challenge the robustness of the off-line calibration model, several blend experiments were conducted using a different bin size, faster revolution speed and variations in the potency of the API. Employing the PLS calibration model developed using the off-line calibration approach, the real-time API NIR (%) predictions for all experiments were all within 90–110%. These results were confirmed using the conventional thief sampling of the final blend followed by high performance liquid chromatography (HPLC) analysis. Further confirmation was established through content uniformity by HPLC of manufactured tablets. Finally, the optimized off-line PLS method was successfully transferred to a production site which involved using a secondary NIR instrument with a 15-fold scale-up in bin size from development. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG monitoring
KW - NEAR infrared reflectance spectroscopy
KW - SOLID dosage forms
KW - QUANTITATIVE research
KW - HIGH performance liquid chromatography
KW - MULTIVARIATE analysis
KW - LEAST squares
KW - Blend uniformity
KW - Near-infrared
KW - Off-line calibration
KW - Partial least-squares
KW - Pharmaceutical
N1 - Accession Number: 36191839; Sulub, Yusuf 1; Email Address: yusuf.sulub@novartis.com Wabuyele, Busolo 1 Gargiulo, Paul 1 Pazdan, James 1 Cheney, James 2 Berry, Joseph 3 Gupta, Abhay 4 Shah, Rakhi 4 Wu, Huiquan 4 Khan, Mansoor 4; Affiliation: 1: Pharmaceutical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, United States 2: Global Quality Operations, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, United States 3: QRxPharma Inc., Somerset, NJ, United States 4: Division of Product Quality Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Springs, MD 20993, United States; Source Info: Jan2009, Vol. 49 Issue 1, p48; Subject Term: DRUG monitoring; Subject Term: NEAR infrared reflectance spectroscopy; Subject Term: SOLID dosage forms; Subject Term: QUANTITATIVE research; Subject Term: HIGH performance liquid chromatography; Subject Term: MULTIVARIATE analysis; Subject Term: LEAST squares; Author-Supplied Keyword: Blend uniformity; Author-Supplied Keyword: Near-infrared; Author-Supplied Keyword: Off-line calibration; Author-Supplied Keyword: Partial least-squares; Author-Supplied Keyword: Pharmaceutical; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jpba.2008.10.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36191839&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reepmeyer, John C.
AU - d’Avignon, D. André
T1 - Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2009/01/15/
VL - 49
IS - 1
M3 - Article
SP - 145
EP - 150
SN - 07317085
AB - Abstract: Two analogues of sildenafil were detected in herbal dietary supplements marketed as aphrodisiacs. Both compounds were identified as thioketone analogues of sildenafil in which the carbonyl group in the pyrimidine ring of sildenafil was substituted with a thiocarbonyl group. The first compound was identified as thiosildenafil, a compound that has recently been reported as an adulterant in health supplements. The structure of the second compound was established using LC–MS, UV spectroscopy, ESI-MS n , NMR and a hydrolytic process. A detailed study of the hydrolysis products of sildenafil, thiosildenafil, and the second unknown compound proved that the second compound, named thiomethisosildenafil, had a structure analogous to sildenafil in which the N-methylpiperazine moiety had been replaced with 2,6-dimethylpiperazine and the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom. Under the hydrolytic reaction conditions employed in this study, thioketones hydrolyze to ketones (e.g., thiosildenafil→sildenafil), making this a valuable technique for the structure elucidation of thiosildenafil analogues. Ten herbal dietary supplements, each as a capsule dosage form, were found to contain 8–151mg of thiomethisosildenafil per capsule, and one herbal dietary supplement was found to contain 35mg of thiosildenafil per capsule. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APHRODISIACS
KW - DIETARY supplements
KW - SILDENAFIL
KW - ULTRAVIOLET spectroscopy
KW - NUCLEAR magnetic resonance
KW - LIQUID chromatography
KW - MASS spectrometry
KW - Dietary supplements
KW - Liquid chromatography–mass spectrometry (LC–MS)
KW - Nuclear magnetic resonance (NMR)
KW - Sildenafil analogue
KW - Thiomethisosildenafil
N1 - Accession Number: 36191853; Reepmeyer, John C. 1; Email Address: john.reepmeyer@fda.hhs.gov d’Avignon, D. André 2; Affiliation: 1: US Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA 2: Department of Chemistry, Washington University, St. Louis, MO 63130, USA; Source Info: Jan2009, Vol. 49 Issue 1, p145; Subject Term: APHRODISIACS; Subject Term: DIETARY supplements; Subject Term: SILDENAFIL; Subject Term: ULTRAVIOLET spectroscopy; Subject Term: NUCLEAR magnetic resonance; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Author-Supplied Keyword: Dietary supplements; Author-Supplied Keyword: Liquid chromatography–mass spectrometry (LC–MS); Author-Supplied Keyword: Nuclear magnetic resonance (NMR); Author-Supplied Keyword: Sildenafil analogue; Author-Supplied Keyword: Thiomethisosildenafil; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jpba.2008.10.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36191853&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gerecke, Donald R.
AU - Chen, Minjun
AU - Isukapalli, Sastry S.
AU - Gordon, Marion K.
AU - Chang, Yoke-Chen
AU - Tong, Weida
AU - Androulakis, Ioannis P.
AU - Georgopoulos, Panos G.
T1 - Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/01/15/
VL - 234
IS - 2
M3 - Article
SP - 156
EP - 165
SN - 0041008X
AB - Abstract: Sulfur mustard (HD, SM), is a chemical warfare agent that within hours causes extensive blistering at the dermal–epidermal junction of skin. To better understand the progression of SM-induced blistering, gene expression profiling for mouse skin was performed after a single high dose of SM exposure. Punch biopsies of mouse ears were collected at both early and late time periods following SM exposure (previous studies only considered early time periods). The biopsies were examined for pathological disturbances and the samples further assayed for gene expression profiling using the Affymetrix microarray analysis system. Principal component analysis and hierarchical cluster analysis of the differently expressed genes, performed with ArrayTrack showed clear separation of the various groups. Pathway analysis employing the KEGG library and Ingenuity Pathway Analysis (IPA) indicated that cytokine–cytokine receptor interaction, cell adhesion molecules (CAMs), and hematopoietic cell lineage are common pathways affected at different time points. Gene ontology analysis identified the most significantly altered biological processes as the immune response, inflammatory response, and chemotaxis; these findings are consistent with other reported results for shorter time periods. Selected genes were chosen for RT-PCR verification and showed correlations in the general trends for the microarrays. Interleukin 1 beta was checked for biological analysis to confirm the presence of protein correlated to the corresponding microarray data. The impact of a matrix metalloproteinase inhibitor, MMP-2/MMP-9 inhibitor I, against SM exposure was assessed. These results can help in understanding the molecular mechanism of SM-induced blistering, as well as to test the efficacy of different inhibitors. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - MICE as laboratory animals
KW - MUSTARD gas
KW - CHEMICAL warfare agents
KW - SKIN -- Physiology
KW - BIOPSY
KW - METALLOPROTEINASES
KW - Alkylating agent
KW - Matrix metalloproteinase
KW - Microarray
KW - MMP
KW - MMP inhibitor
KW - Skin
KW - Sulfur mustard
KW - Vesicant
N1 - Accession Number: 36062096; Gerecke, Donald R. 1; Email Address: gerecke@eohsi.rutgers.edu Chen, Minjun 1 Isukapalli, Sastry S. 1 Gordon, Marion K. 1 Chang, Yoke-Chen 1 Tong, Weida 2 Androulakis, Ioannis P. 3 Georgopoulos, Panos G. 1; Affiliation: 1: Environmental and Occupational Health Sciences Institute (EOHSI), a Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA 2: US FDA, National Center for Toxicological Research, Jefferson, AK, USA 3: Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Source Info: Jan2009, Vol. 234 Issue 2, p156; Subject Term: GENE expression; Subject Term: MICE as laboratory animals; Subject Term: MUSTARD gas; Subject Term: CHEMICAL warfare agents; Subject Term: SKIN -- Physiology; Subject Term: BIOPSY; Subject Term: METALLOPROTEINASES; Author-Supplied Keyword: Alkylating agent; Author-Supplied Keyword: Matrix metalloproteinase; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: MMP; Author-Supplied Keyword: MMP inhibitor; Author-Supplied Keyword: Skin; Author-Supplied Keyword: Sulfur mustard; Author-Supplied Keyword: Vesicant; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2008.09.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36062096&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - Krajnak, Kristine
AU - Welcome, Daniel E.
AU - Dong, Ren G.
T1 - Analysis of the biodynamic interaction between the fingertip and probe in the vibrotactile tests: The influences of the probe/fingertip contact orientation and static indentation
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2009/01/19/
VL - 42
IS - 2
M3 - Article
SP - 116
EP - 124
SN - 00219290
AB - Abstract: Vibrotactile thresholds at the fingertips are affected by a number of individual, environmental, and testing factors. In the current study, we theoretically analyzed the effects of the contact orientation of the probe on the fingertip and the static pre-indentation on the dynamic deformation of the soft tissues of the fingertip in the vibrotactile tests using a nonlinear finite element model. The fingertip considered in the 3D finite element model is the distal phalanx, the portion from the distal end to the distal interphalangeal (DIP) joint articulation. The fingertip is contacted by the probe at four different contact locations, which are regulated by contact angles (, , , and ), and three different pre-indentations (0.5, 1.0, and 1.5mm). The model predictions indicated that the average spatial summation of the vibration displacement (SVD) at the fingertip depends on the static pre-indentation and the probe/indentor contact orientation; although the resonance characteristics of the fingertip are not affected by either the pre-indentation or the contact location. The location-dependence of the vibration exposure factors at the fingertip was found to increase with increasing static pre-indentation. At a static indentation of 1.5mm, the test condition specified in the ISO-13091-1 standard, the values of the SVDs determined at different probe/fingertip contact orientations differ as much as 125%. Since the dynamic displacements of the soft tissues are believed to affect the vibrotactile threshold, the current results suggest that the contact orientation of the probe on the fingertip should be strictly defined and restricted to obtain reliable results in the vibrotactile perception threshold tests. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMECHANICS
KW - FINITE element method
KW - NONLINEAR models (Statistics)
KW - CONTACT mechanics
KW - VISCOELASTICITY
KW - VIBRATION (Mechanics)
KW - Contact pressure
KW - Fingertip
KW - Finite element model
KW - Soft tissue mechanics
KW - Vibration
KW - Viscoelasticity
N1 - Accession Number: 36105172; Wu, John Z.; Email Address: ozw8@cdc.gov Krajnak, Kristine 1 Welcome, Daniel E. 1 Dong, Ren G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA; Source Info: Jan2009, Vol. 42 Issue 2, p116; Subject Term: BIOMECHANICS; Subject Term: FINITE element method; Subject Term: NONLINEAR models (Statistics); Subject Term: CONTACT mechanics; Subject Term: VISCOELASTICITY; Subject Term: VIBRATION (Mechanics); Author-Supplied Keyword: Contact pressure; Author-Supplied Keyword: Fingertip; Author-Supplied Keyword: Finite element model; Author-Supplied Keyword: Soft tissue mechanics; Author-Supplied Keyword: Vibration; Author-Supplied Keyword: Viscoelasticity; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jbiomech.2008.10.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36105172&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shamliyan, Tatyana A.
AU - MacDonald, Roderick
AU - Shaukat, Aasma
AU - Taylor, Brent C.
AU - Jian-Min Yuan
AU - Johnson, James R.
AU - Tacklind, James
AU - Rutks, Indulis
AU - Kane, Robert L.
AU - Wilt, Timothy J.
T1 - Antiviral Therapy for Adults With Chronic Hepatitis B: A Systematic Review for a National Institutes of Health Consensus Development Conference.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/01/20/
VL - 150
IS - 2
M3 - Article
SP - 111
EP - W20
SN - 00034819
AB - Background: Chronic hepatitis B infection can lead to liver failure, hepatocellular carcinoma, and death. Purpose: To evaluate the effectiveness of antiviral therapy for adults with chronic hepatitis B infection. Data Sources: Randomized, controlled trials (RCTs) of interferon (α2b and pegylated α2a), lamivudine, adefovir, entecavir, and telbivudine published from 1990 to 2008. Study Selection: Randomized, controlled clinical trials of adults with chronic hepatitis B published in English after 1989 that reported death; incidence of hepatocellular carcinoma or liver failure; prevalence and incidence of cirrhosis; presence or seroconversion of hepatitis B e antigen (HBeAg) or surface antigen (HBsAg), viral load of hepatitis B virus DNA; aspartate aminotransferase and alanine aminotransferase (ALT) levels; or fibrosis scores after therapy with interferon-α2b, pegylated interferon-α2a, lamivudine, adefovir, entecavir, and telbivudine. Data Extraction: Data extracted with standard protocols to calculate risk difference for clinical outcomes, viral load, HBeAg and HBsAg, ALT, histologic scores, and adverse events. Data Synthesis: In 16 RCTs (4431 patients), drug treatment did not improve clinical outcomes of chronic hepatitis B infection, but the trials were underpowered. In 60 RCTs that examined intermediate outcomes, no single treatment improved all intermediate outcomes. Low-quality evidence suggested HBsAg clearance after interferon- α2b (2 RCTs; 211 patients). Moderate-quality evidence suggested ALT normalization at follow-up after treatment with adefovir (2 RCTs; 600 patients) and HBeAg loss with lamivudine (2 RCTs; 318 patients). With interferon-α2b, moderate-quality evidence suggested HBeAg loss (3 RCTs; 351 patients), seroconversion (2 RCTs; 304 patients), and ALT normalization (2 RCTs; 131 patients). Pegylated interferon-α2a versus lamivudine improved HBeAg seroconversion (1 RCT; 814 patients) and ALT normalization (2 RCTs; 905 patients) off treatment. Pegylated interferon-α2a combined with lamivudine versus lamivudine improved HBeAg loss (1 RCT; 543 patients) and ALT normalization (2 RCTs; 905 patients). Adverse events during antiretroviral therapy occurred in more than 50% of patients but were not associated with increased treatment discontinuation. However, most studies excluded patients with hepatic or renal insufficiency or other serious comorbid conditions. Limitation: Marked heterogeneity in study samples, interventions, and measured outcomes preclude definitive conclusions. Conclusion: Evidence was insufficient to assess treatment effect on clinical outcomes or determine whether inconsistent improvements in selected intermediate measures are reliable surrogates. Future research is needed to provide evidence-based recommendations about optimal antiviral therapy in adults with chronic hepatitis B infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - ADULTS
KW - HEALTH
KW - LYMPHOKINES
KW - LIVER -- Cancer
KW - HEPATITIS B
KW - PATHOLOGICAL histology
KW - CIRRHOSIS of the liver
N1 - Accession Number: 36182100; Shamliyan, Tatyana A. 1 MacDonald, Roderick 2 Shaukat, Aasma 3 Taylor, Brent C. 2 Jian-Min Yuan 4 Johnson, James R. 5 Tacklind, James Rutks, Indulis 2 Kane, Robert L. 6 Wilt, Timothy J. 2; Affiliation: 1: Division of Health Policy and Management, University of Minnesota School of Public Health, D351 Mayo (MMC 197), 420 Delaware Street SE, Minneapolis, MN 2: Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417 3: Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical School, 420 Delaware Street SE (MMC 36), Minneapolis, MN 55455 4: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Room 300, West Bank Office Building, 1300 South Second Street, Minneapolis, MN 55454 5: Department of Infectious Diseases, Minneapolis Veterans Affairs Medical Center (111-F), 1 Veterans Drive, Minneapolis, MN 55417 6: Agency for Healthcare Research and Quality Center for Chronic Disease Outcomes Research and the Cochrane Prostatic Diseases and Urologic Cancers Group, Minneapolis Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417; Source Info: 1/20/2009, Vol. 150 Issue 2, p111; Subject Term: ANTIVIRAL agents; Subject Term: ADULTS; Subject Term: HEALTH; Subject Term: LYMPHOKINES; Subject Term: LIVER -- Cancer; Subject Term: HEPATITIS B; Subject Term: PATHOLOGICAL histology; Subject Term: CIRRHOSIS of the liver; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 15p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Brinker, Allen D.
T1 - Allopurinol and the Role of Uric Acid in Hypertension.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/01/21/
VL - 301
IS - 3
M3 - Letter
SP - 270
EP - 270
SN - 00987484
AB - A letter to the editor is presented in response to the article "Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial," by D.I. Feig, B. Soletsky, and R.J. Johnson.
KW - LETTERS to the editor
KW - HYPERTENSION -- Treatment
N1 - Accession Number: 36149191; Brinker, Allen D. 1; Email Address: allen.brinker@fda.hhs.gov; Affiliation: 1: Division of Epidemiology Office of Surveillance and Epidemiology FDA Center for Drug Evaluation and Research Silver Spring, Maryland; Source Info: 1/21/2009, Vol. 301 Issue 3, p270; Subject Term: LETTERS to the editor; Subject Term: HYPERTENSION -- Treatment; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - He, Zhi-Heng
AU - He, Ming-Fang
AU - Ma, Shuang-Cheng
AU - But, Paul Pui-Hay
T1 - Anti-angiogenic effects of rhubarb and its anthraquinone derivatives
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
Y1 - 2009/01/21/
VL - 121
IS - 2
M3 - Article
SP - 313
EP - 317
SN - 03788741
AB - Abstract: Ethnopharmacological relevance: Rhubarb root (Dahuang) is often included as an ingredient in traditional Chinese compound prescriptions for the treatment of inflammatory diseases. This application may possibly be mediated through anti-angiogensis and thus would shed light on its potential value in cancer therapy. Aim of the study: To elucidate the anti-angiogenic properties of rhubarb root, we tested the inhibitory effects of different fractions and a series of anthraquinone derivatives against vessel formation in zebrafish embryos. Materials and methods: The 95% ethanol extract and four subsequent fractions (n-hexane, ethyl acetate, n-butanol and aqueous fractions) of rhubarb root and five anthraquinone derivatives were investigated on zebrafish model by quantitative endogenous alkaline phosphatase assay and staining assay. Results: Ethyl acetate fraction showed the strongest inhibition of vessel formation by 52%. Three anthraquinones (aloe-emodin, emodin and rhein) displayed potent anti-angiogenic activities. Conclusions: The angiogenic properties of rhubarb root may partly account for its use in inflammatory diseases. The anthraquinones with acidic or polar, hydrophilic substitution at C-6 or C-3 positions played a substantial role in inhibiting angiogenesis. The value of the zebrafish angiogenic model is further supported. [Copyright &y& Elsevier]
AB - Copyright of Journal of Ethnopharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RHUBARB
KW - ANTHRAQUINONES
KW - CHINESE medicine
KW - PLANT extracts
KW - RHEUM
KW - ANTI-inflammatory agents
KW - THERAPEUTIC use
KW - Anthraquinone
KW - Anti-angiogenesis
KW - Rhein
KW - Rheum
KW - Rhubarb
KW - Zebrafish
N1 - Accession Number: 35938187; He, Zhi-Heng 1 He, Ming-Fang 1 Ma, Shuang-Cheng 2 But, Paul Pui-Hay 1; Email Address: paulbut@cuhk.edu.hk; Affiliation: 1: Food and Drug Authentication Laboratory, Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China 2: Department of Drug Administration, National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing, PR China; Source Info: Jan2009, Vol. 121 Issue 2, p313; Subject Term: RHUBARB; Subject Term: ANTHRAQUINONES; Subject Term: CHINESE medicine; Subject Term: PLANT extracts; Subject Term: RHEUM; Subject Term: ANTI-inflammatory agents; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Anthraquinone; Author-Supplied Keyword: Anti-angiogenesis; Author-Supplied Keyword: Rhein; Author-Supplied Keyword: Rheum; Author-Supplied Keyword: Rhubarb; Author-Supplied Keyword: Zebrafish; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jep.2008.11.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Heederik, Dick
AU - Attfield, Michael
T1 - Characterization of Dust Exposure for the Study of Chronic Occupational Lung Disease: A Comparison of Different Exposure Assessment Strategies.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/01/29/
VL - 151
IS - 10
M3 - Article
SP - 982
EP - 990
SN - 00029262
AB - Various exposure assessment strategies were compared in the study of the relation between dust exposure and 11-year lung function change in 1, 172 miners with 36, 824 concurrently measured personal dust samples available from the 1969–1981 US National Study of Coal Workers‘ Pneumoconiosis. A miner’s average exposure was assessed by calculating average exposures based on dust samples taken from each individual and by using different job exposure matrices (JEMs) with different underlying exposure categorizations, based on occupational categories, job title, mine, and time, to obtain average exposure estimates. For each grouping procedure, intragroup and intergroup variances and the pooled standard error of the mean were calculated to assess relative efficiency. The results show that considerable variation in slopes of exposure-response relations was found using different exposure assessment strategies. Standard errors of the slopes of the exposure-response relations with exposure on an individual basis compared with JEMs. Exposure assessment on an individual basis was extremely sensitive to the number of exposure measurements per individual. The study demonstrates the advantages and disadvantages of different exposure assessment strategies and shows the need for explicit publication of exposure assessment strategies for epidemiologic studies. Careful assessment of the influence of misclassification error in the exposure assessment on exposure-response modeling is warranted. Am J Epidemiol 2000; 151: 982–90. [ABSTRACT FROM PUBLISHER]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases
KW - OCCUPATIONAL diseases -- Risk factors
KW - THRESHOLD limit values (Industrial toxicology)
KW - LUNG diseases
KW - RESEARCH
KW - RESPIRATORY function tests
KW - RISK factors
KW - forced expiratory volume
KW - lung diseases
KW - obstructive
KW - occupational diseases
KW - respiratory function tests
N1 - Accession Number: 82416674; Heederik, Dick 1,2 Attfield, Michael 2; Affiliation: 1: Environmental and Occupational Health Group, University of Utrecht Utrecht, Netherlands 2: Division of Respiratory Disease Studies, Epidemiology Branch, National Institute for Occupational Safety and Health Morgantown, WV; Source Info: 2000, Vol. 151 Issue 10, p982; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: OCCUPATIONAL diseases -- Risk factors; Subject Term: THRESHOLD limit values (Industrial toxicology); Subject Term: LUNG diseases; Subject Term: RESEARCH; Subject Term: RESPIRATORY function tests; Subject Term: RISK factors; Author-Supplied Keyword: forced expiratory volume; Author-Supplied Keyword: lung diseases; Author-Supplied Keyword: obstructive; Author-Supplied Keyword: occupational diseases; Author-Supplied Keyword: respiratory function tests; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Che-Hung
AU - Kuo, Wen-Chun
AU - Beri, Suresh
AU - Kapre, Subash
AU - Joshi, Jayant S.
AU - Bouveret, Nancy
AU - LaForce, F. Marc
AU - Frasch, Carl E.
T1 - Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa
JO - Vaccine
JF - Vaccine
Y1 - 2009/01/29/
VL - 27
IS - 5
M3 - Article
SP - 726
EP - 732
SN - 0264410X
AB - Abstract: Periodic epidemics of group A meningococcal (Mn A) meningitis continue to occur in sub-Saharan Africa. For its prevention, a Mn A polysaccharide (PS)–tetanus toxoid (TT) conjugate vaccine was developed using reductive amination of polysaccharide aldehydes and toxoid hydrazides. In mouse immunization studies, a schedule of three bi-weekly s.c. immunizations of 0.1 or 1μg of the conjugate (PS content) without an adjuvant induced serum antibody levels of >10,000units/mL measured by enzyme-linked immunosorbent assay (ELISA) as compared to ∼100units/mL in PS control mice. The elicited antibodies were active in bactericidal assays using either baby rabbit or human complement (titers >1500 compared to ∼200 for the PS control group). The synthesis process is reproducible and scalable, and has been successfully used for manufacturing a Mn A PS–TT conjugate vaccine based on a paradigm of shared manufacturing with transfer of new technology [Jodar L, LaForce FM, Ceccarini C, Aguado T, Granoff DM. Meningococcal conjugate vaccine for Africa: a model for development of new vaccine for the poorest countries. Lancet 2003, 361:1092–4]. A phase 1 clinical trial of the manufactured Men A–TT conjugate vaccine has been successfully carried out in adults in India, and a phase 2 clinical trial in young children is currently underway in Africa. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - VACCINATION
KW - Immunization
KW - Vaccines
KW - Cerebrospinal meningitis
KW - Bioconjugates
KW - Aldehydes
KW - Amination
KW - Immunoglobulins
KW - Clinical trials
KW - India
KW - Africa, Sub-Saharan
KW - Conjugate
KW - Polysaccharide
KW - Vaccine
N1 - Accession Number: 36194391; Lee, Che-Hung 1; Email Address: robert.lee@fda.hhs.gov; Kuo, Wen-Chun 1; Beri, Suresh 2; Kapre, Subash 2; Joshi, Jayant S. 2; Bouveret, Nancy 3; LaForce, F. Marc 3; Frasch, Carl E. 1; Affiliations: 1: Center for Biologics Evaluation and Research, Bethesda, MD, USA; 2: Serum Institute of India, Ltd., Pune, India; 3: Meningitis Vaccine Project, Ferney-Voltaire, France; Issue Info: Jan2009, Vol. 27 Issue 5, p726; Thesaurus Term: RESEARCH; Thesaurus Term: VACCINATION; Thesaurus Term: Immunization; Subject Term: Vaccines; Subject Term: Cerebrospinal meningitis; Subject Term: Bioconjugates; Subject Term: Aldehydes; Subject Term: Amination; Subject Term: Immunoglobulins; Subject Term: Clinical trials; Subject: India; Subject: Africa, Sub-Saharan; Author-Supplied Keyword: Conjugate; Author-Supplied Keyword: Polysaccharide; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.11.065
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xia, Xiaodong
AU - Zhao, Shaohua
AU - Smith, Allen
AU - McEvoy, James
AU - Meng, Jianghong
AU - Bhagwat, Arvind A.
T1 - Characterization of Salmonella isolates from retail foods based on serotyping, pulse field gel electrophoresis, antibiotic resistance and other phenotypic properties
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/01/31/
VL - 129
IS - 1
M3 - Article
SP - 93
EP - 98
SN - 01681605
AB - Abstract: Sixteen Salmonella strains isolated from a variety of foods during 2000 and 2003 by the Florida State Department of Agriculture were characterized by various genotypic and phenotypic tests. Among 16 isolates, 15 different serotypes were identified. Pulse-field gel electrophoresis (PFGE) fingerprinting profiles obtained using restriction endonucleases XbaI and BlnI revealed that 16 Salmonella isolates were genetically diverse with 16 unique PFGE patterns. The PFGE pattern of eight isolates matched with the CDC/FDA data base of previous outbreaks and clinical isolates indicating their potential to cause disease. With the exception of isolates obtained from alligator meat (tetracycline resistant) and orange juice (chloramphenicol and sulfisoxazole resistant), the remainder of the isolates were susceptible to the panel of 15 antimicrobials tested. Molecular subtyping was further complimented by a variety of phenotypic tests such as acid-tolerance, Caco-2 cell invasion and biofilm formation which have often been used as a gauge of virulence and infection potential of Salmonella isolates. The induced acid tolerance level of the isolate obtained from orange juice was not significantly different from the laboratory reference strain S. enterica serovar Typhimurium SL1344. Six isolates exhibited very low levels of constitutive acid-tolerance, of which four isolates failed to infect differentiated Caco-2 cells. Although all isolates formed biofilms, there was no clear relation between the ability to form biofilms, infect differentiated Caco-2 cells and induce acid-tolerance. This study indicated that different serotypes of Salmonella were present in a variety of retail foods and exhibited diverse phenotypic characteristics. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food production
KW - Foodborne diseases
KW - Salmonella
KW - Microbial ecology
KW - Biofilms
KW - DNA fingerprinting
KW - Pulsed-field gel electrophoresis
KW - Endonucleases -- Abstracts
KW - Food-borne pathogens
KW - Pulse field gel electrophoresis (PFGE)
N1 - Accession Number: 35924558; Xia, Xiaodong 1,2; Zhao, Shaohua 3; Smith, Allen 4; McEvoy, James 1; Meng, Jianghong 2; Bhagwat, Arvind A. 1; Email Address: arvind.bhagwat@ars.usda.gov; Affiliations: 1: Produce Quality and Safety Laboratory, Agricultural Research Service, USDA, 10300 Baltimore Avenue, Bldg. 002, BARC-W, Beltsville, MD 20705-2350, United States; 2: Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742-7521, United States; 3: Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708-2482, United States; 4: Diet Genomics and Immunology Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, 10300 Baltimore Avenue, Bldg. 002, BARC-W, Beltsville, MD 20705-2350, United States; Issue Info: Jan2009, Vol. 129 Issue 1, p93; Thesaurus Term: Food production; Thesaurus Term: Foodborne diseases; Thesaurus Term: Salmonella; Thesaurus Term: Microbial ecology; Thesaurus Term: Biofilms; Thesaurus Term: DNA fingerprinting; Subject Term: Pulsed-field gel electrophoresis; Subject Term: Endonucleases -- Abstracts; Author-Supplied Keyword: Food-borne pathogens; Author-Supplied Keyword: Pulse field gel electrophoresis (PFGE); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2008.11.007
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DP - EBSCOhost
DB - eih
ER -
TY - CONF
AU - Longley, Lan
AU - Kingham, Simon
AU - Jalaludin, Bin
AU - Barnfather, Denise
T1 - The Joint Conference of the International Societies of Environmental Epidemiology and Exposure.
JO - Air Quality & Climate Change
JF - Air Quality & Climate Change
Y1 - 2009/02//
VL - 43
IS - 1
M3 - Proceeding
SP - 11
EP - 12
SN - 18365876
AB - The article discusses the highlights of the joint conference of the International Societies of Environmental Epidemiology and Exposure Analysis held in Pasadena, Southern California in October 2008. Three speakers at the event were Ian Longley, Tim Buckley and Simon Kingham. One of the issues tackled is poor air quality and its impact on public health.
KW - CONFERENCES & conventions
KW - AIR quality
KW - PUBLIC health -- Congresses
KW - CONGRESSES
KW - PASADENA (Calif.)
KW - CALIFORNIA
KW - LONGLEY, Ian
KW - BUCKLEY, Tim
KW - KINGHAM, Simon
N1 - Accession Number: 48998252; Longley, Lan 1 Kingham, Simon 2 Jalaludin, Bin 3 Barnfather, Denise 4; Affiliation: 1: Air Quality Scientist, NIWA, Auckland 2: Associate Professor, Department of Geography, University of Canterbury, Christchurch 3: Director, Centre for Research, Evidence Management and Surveillance, Sydney South West Area Health Service 4: Public Health Specialist, Auckland Regional Public Health Service; Source Info: Feb2009, Vol. 43 Issue 1, p11; Subject Term: CONFERENCES & conventions; Subject Term: AIR quality; Subject Term: PUBLIC health -- Congresses; Subject Term: CONGRESSES; Subject Term: PASADENA (Calif.); Subject Term: CALIFORNIA; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 525120 Health and Welfare Funds; People: LONGLEY, Ian; People: BUCKLEY, Tim; People: KINGHAM, Simon; Number of Pages: 2p; Document Type: Proceeding
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dabkowski, Erinne R.
AU - Williamson, Courtney L.
AU - Bukowski, Valerie C.
AU - Chapman, Rebecca S.
AU - Leonard, Stephen S.
AU - Peer, Cody J.
AU - Callery, Patrick S.
AU - Hollander, John M.
T1 - Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.
JO - American Journal of Physiology: Heart & Circulatory Physiology
JF - American Journal of Physiology: Heart & Circulatory Physiology
Y1 - 2009/02//
VL - 296
IS - 2
M3 - Article
SP - H359
EP - H369
SN - 03636135
AB - Diabetic cardiomyopathy is the leading cause of heart failure among diabetic patients, and mitochondrial dysfunction has been implicated as an underlying cause in the pathogenesis. Cardiac mitochondria consist of two spatially, functionally, and morphologically distinct subpopulations, termed subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). SSM are situated beneath the plasma membrane, whereas IFM are embedded between myofibrils. The goal of this study was to determine whether spatially distinct cardiac mitochondrial subpopulations respond differently to a diabetic phenotype. Swiss-Webster mice were subjected to intraperitoneal injections of streptozotocin or citrate saline vehicle. Five weeks after injections, diabetic hearts displayed decreased rates of contraction, relaxation, and left ventricular developed pressures (P < 0.05 for all three). Both mitochondrial size (forward scatter, P < 0.01) and complexity (side scatter, P < 0.01) were decreased in diabetic IFM but not diabetic SSM. Electron transport chain complex II respiration was decreased in diabetic SSM (P < 0.05) and diabetic IFM (P < 0.01), with the decrease being greater in IFM. Furthermore, IFM complex I respiration and complex III activity were decreased with diabetes (P < 0.01) but were unchanged in SSM. Superoxide production was increased only in diabetic IFM (P < 0.01). Oxidative damage to proteins and lipids, indexed through nitrotyrosine residues and lipid peroxidation, were higher in diabetic IFM (P < 0.05 and P < 0.01, respectively). The mitochondria-specific phospholipid cardiolipin was decreased in diabetic IFM (P < 0.01) but not SSM. These results indicate that diabetes mellitus imposes a greater stress on the IFM subpopulation, which is associated, in part, with increased superoxide generation and oxidative damage, resulting in morphological and functional abnormalities that may contribute to the pathogenesis of diabetic cardiomyopathy. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Heart & Circulatory Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES
KW - CARDIOMYOPATHIES
KW - MITOCHONDRIA
KW - HEART failure
KW - RELAXATION (Health)
KW - ELECTRON transport
KW - diabetes
KW - free radical
KW - mitochondria
N1 - Accession Number: 36394704; Dabkowski, Erinne R. 1 Williamson, Courtney L. 1 Bukowski, Valerie C. 2 Chapman, Rebecca S. 2 Leonard, Stephen S. 2 Peer, Cody J. 3 Callery, Patrick S. 3 Hollander, John M. 1; Email Address: jhollander@hsc.wvu.edu; Affiliation: 1: Division of Exercise Physiology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine 2: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 3: Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown; Source Info: Feb2009, Vol. 296 Issue 2, pH359; Subject Term: DIABETES; Subject Term: CARDIOMYOPATHIES; Subject Term: MITOCHONDRIA; Subject Term: HEART failure; Subject Term: RELAXATION (Health); Subject Term: ELECTRON transport; Author-Supplied Keyword: diabetes; Author-Supplied Keyword: free radical; Author-Supplied Keyword: mitochondria; Number of Pages: 11p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1152/ajpheart.00467.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105447541
T1 - Justice system involvement into young adulthood: comparison of adolescent girls in the public mental health system and in the general population.
AU - Davis M
AU - Fisher WH
AU - Gershenson B
AU - Grudzinskas AJ
AU - Banks SM
Y1 - 2009/02//
N1 - Accession Number: 105447541. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Psychiatry/Psychology; Public Health. Grant Information: National Institute of Mental Health (grant R01 MH067862-01A1). NLM UID: 1254074.
KW - Juvenile Offenders
KW - Mental Health Services -- Utilization
KW - Public Sector -- Massachusetts
KW - Adolescence
KW - Age Factors
KW - Census
KW - Child
KW - Comparative Studies
KW - Courts
KW - Crime
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Massachusetts
KW - Prospective Studies
KW - Reference Databases -- Massachusetts
KW - Rehabilitation
KW - Human
SP - 234
EP - 236
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - 2
CY - Washington, District of Columbia
PB - American Public Health Association
AB - We compared arrest onset and frequency and types of charges between a statewide cohort of adolescent girls in the public mental health system and girls of the same age in the general population to investigate important differences that could have policy or intervention implications. Girls in the public mental health system were arrested at earlier ages more frequently and were charged with more serious offenses than were girls in the general population. Our results strongly argue for cooperation between the public mental health and justice systems to provide mental health and offender rehabilitation in their shared population.
SN - 0090-0036
AD - Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA 01655, USA; maryann.davis@umassmed.edu
U2 - PMID: 19059845.
DO - 10.2105/AJPH.2008.141135
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105447543
T1 - Oral health of Early Head Start children: a qualitative study of staff, parents, and pregnant women.
AU - Mofidi M
AU - Zeldin LP
AU - Rozier RG
Y1 - 2009/02//
N1 - Accession Number: 105447543. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Dental Care; Pediatric Care; Public Health. Grant Information: Centers for Medicare and Medicaid Services; Health Resources and Services Administration; and Centers for Disease Control and Prevention (grant 11-P-91251/5). NLM UID: 1254074.
KW - Expectant Mothers
KW - Health Knowledge
KW - Oral Health -- Education
KW - Parents -- Psychosocial Factors
KW - Project Head Start -- Manpower
KW - Adult
KW - Attitude of Health Personnel
KW - Audiorecording
KW - Child, Preschool
KW - Confusion
KW - Descriptive Statistics
KW - Early Childhood Intervention -- Standards
KW - Female
KW - Focus Groups
KW - Funding Source
KW - North Carolina
KW - Pregnancy
KW - Professional-Client Relations
KW - Purposive Sample
KW - Qualitative Studies
KW - Thematic Analysis
KW - Human
SP - 245
EP - 251
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - 2
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: We explored the oral health knowledge, attitudes, and activities of Early Head Start (EHS) staff members, parents, and pregnant women, along with their suggestions related to future oral health educational interventions targeting EHS children. METHODS: Nine focus groups were conducted with EHS staff, parents, and pregnant women. Audiotapes of sessions were transcribed and entered into ATLAS.ti 5.0 for coding and analysis. RESULTS: Attitudes about the importance of children's oral health among parents and pregnant women were mixed. Staff members voiced responsibility for children's oral health but frustration in their inability to communicate effectively with parents. Parents in turn perceived staff criticism regarding how they cared for their children's oral health. Gaps were noted in the oral health activities of EHS programs. Participants expressed confusion regarding the application of Head Start oral health performance standards to EHS. The need for culturally sensitive, hands-on oral health education was highlighted. CONCLUSIONS: Tailored, theory-based interventions are needed to improve communication between EHS staff and families. Clear policies on the application of Head Start oral health performance standards to EHS are warranted. Educational activities should address the needs and suggestions of EHS participants.
SN - 0090-0036
AD - Schools of Dentistry and Public Health, University of North Carolina, Chapel Hill, NC, USA; mmofidi@hrsa.gov
U2 - PMID: 19059853.
DO - 10.2105/AJPH.2008.133827
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105447543&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gobburu, Jogarao V. S.
AU - Lesko, Lawrence J.
T1 - Quantitative Disease, Drug, and Trial Models.
JO - Annual Review of Pharmacology & Toxicology
JF - Annual Review of Pharmacology & Toxicology
Y1 - 2009/02//
VL - 49
IS - 1
M3 - Article
SP - 291
EP - 301
SN - 03621642
AB - Quantitative disease-drug-trial models allow learning from prior experience and summarize the knowledge in a ready to apply format. Employing these models to plan future development is proposed as a powerful solution to improve pharmaceutical R&D productivity. The disease and trial models are, to a large extent, independent of the product, but the drug model is not. The goals are to apply the disease and trial models to future development and regulatory decisions, and publicly share them. We propose working definitions of these models, describe the various subcomponents, provide examples, and discuss the challenges and potential solutions for developing such models. Building useful disease-drug-trial models is a challenging task and cannot be achieved by any single organization. It requires a consorted effort by industry, academic, and regulatory scientists. We also describe the strategic goals of the FDA Pharmacometrics group. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annual Review of Pharmacology & Toxicology is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG development
KW - PHARMACEUTICAL research
KW - RESEARCH & development
KW - QUANTITATIVE research
KW - SIMULATION methods & models
KW - SYSTEMS biology
KW - UNITED States
KW - drug development
KW - exposure response
KW - model-based drug development
KW - regulatory decisions
KW - simulation
KW - trial design
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36805200; Gobburu, Jogarao V. S. 1; Email Address: jogarao.gobburu@fda.hhs.gov Lesko, Lawrence J. 1; Affiliation: 1: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993-0002, USA; Source Info: 2009, Vol. 49 Issue 1, p291; Subject Term: DRUG development; Subject Term: PHARMACEUTICAL research; Subject Term: RESEARCH & development; Subject Term: QUANTITATIVE research; Subject Term: SIMULATION methods & models; Subject Term: SYSTEMS biology; Subject Term: UNITED States; Author-Supplied Keyword: drug development; Author-Supplied Keyword: exposure response; Author-Supplied Keyword: model-based drug development; Author-Supplied Keyword: regulatory decisions; Author-Supplied Keyword: simulation; Author-Supplied Keyword: trial design; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 11p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1146/annurev.pharmtox.011008.145613
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105448296
T1 - AHRQ commentary. Patient safety organizations ready for action.
AU - Clancy CM
Y1 - 2009/02//
N1 - Accession Number: 105448296. Language: English. Entry Date: 20090410. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 0372403.
KW - Health Care Errors -- Prevention and Control
KW - Patient Safety
KW - Privacy and Confidentiality
KW - Quality of Health Care -- Methods
KW - Organizational Objectives
KW - Quality Improvement
KW - United States
KW - United States Agency for Healthcare Research and Quality
SP - 385
EP - 387
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 89
IS - 2
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 19200469.
DO - 10.1016/j.aorn.2009.01.017
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Harrison, Joel C.
AU - Wells, J.R.
T1 - Gas-phase chemistry of benzyl alcohol: Reaction rate constants and products with OH radical and ozone
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2009/02//
VL - 43
IS - 4
M3 - Article
SP - 798
EP - 804
SN - 13522310
AB - A bimolecular rate constant, k OH+Benzyl alcohol, of (28±7)×10−12 cm3 molecule−1 s−1 was measured using the relative rate technique for the reaction of the hydroxyl radical (OH) with benzyl alcohol, at (297±3)K and 1atm total pressure. Additionally, an upper limit of the bimolecular rate constant, k O3+Benzyl alcohol, of approximately 6×10−19 cm3 molecule−1 s−1 was determined by monitoring the decrease in benzyl alcohol concentration over time in an excess of ozone (O3). To more clearly define part of benzyl alcohol''s indoor environment degradation mechanism, the products of the benzyl alcohol+OH were also investigated. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) were used to positively identify benzaldehyde, glyoxal and 4-oxopentanal as benzyl alcohol/OH reaction products. The elucidation of other reaction products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible benzyl alcohol/OH reaction mechanisms based on previously published volatile organic compound/OH gas-phase reaction mechanisms. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Indoor air pollution -- Research
KW - Air pollution -- Measurement
KW - Mass spectrometry
KW - Hydroxyl group
KW - Ozone -- Environmental aspects
KW - Hydroxylamine
KW - Acetamide -- Environmental aspects
KW - Benzaldehyde
KW - Glyoxal
KW - Benzyl alcohol
KW - Indoor chemistry
KW - OH rate constant
KW - Ozone rate constant
N1 - Accession Number: 35939567; Harrison, Joel C. 1; Wells, J.R.; Email Address: ozw0@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Feb2009, Vol. 43 Issue 4, p798; Thesaurus Term: Indoor air pollution -- Research; Thesaurus Term: Air pollution -- Measurement; Thesaurus Term: Mass spectrometry; Subject Term: Hydroxyl group; Subject Term: Ozone -- Environmental aspects; Subject Term: Hydroxylamine; Subject Term: Acetamide -- Environmental aspects; Subject Term: Benzaldehyde; Subject Term: Glyoxal; Author-Supplied Keyword: Benzyl alcohol; Author-Supplied Keyword: Indoor chemistry; Author-Supplied Keyword: OH rate constant; Author-Supplied Keyword: Ozone rate constant; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.atmosenv.2008.11.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=35939567&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
T1 - Telomere Length, Current Perceived Stress, and Urinary Stress Hormones in Women.
AU - Parks, Christine G.
AU - Miller, Diane B.
AU - McCanlies, Erin C.
AU - Cawthon, Richard M.
AU - Andrew, Michael E.
AU - DeRoo, Lisa A.
AU - Sandler, Dale P.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2009/02//
VL - 18
IS - 2
SP - 551
EP - 560
SN - 10559965
N1 - Accession Number: 36643959; Author: Parks, Christine G.: 1 email: Parks1@mail.nih.gov. Author: Miller, Diane B.: 2 Author: McCanlies, Erin C.: 3 Author: Cawthon, Richard M.: 4 Author: Andrew, Michael E.: 3 Author: DeRoo, Lisa A.: 1 Author: Sandler, Dale P.: 1 ; Author Affiliation: 1 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina: 2 Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia: 3 Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia: 4 Department of Human Genetics, University of Utah, Salt Lake City, Utah; No. of Pages: 10; Language: English; Publication Type: Article; Update Code: 20090226
N2 - The article presents a study which aims to explore on the significant role of perceived stress and telomere length to women's urinary stress hormones. The study was conducted at the National Institute of Environmental Health Sciences Sister Study and along with 647 women participants who have closest kin succumbed with breast cancer. It was determined that telomere length depends of external stressors, age, and responsiveness of the neuroendocrine.
KW - *STRESS (Psychology)
KW - *HORMONES
KW - *WOMEN -- Health
KW - TELOMERES -- Research
KW - RESEARCH
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Mi Park, Eun
AU - Lee, Eunil
AU - Jin Joo, Hyun
AU - Oh, Eunha
AU - Lee, Joohyun
AU - Lee, Ji-Sung
T1 - Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using 1H NMR spectroscopy.
JO - Clinical Chemistry & Laboratory Medicine
JF - Clinical Chemistry & Laboratory Medicine
Y1 - 2009/02//
VL - 47
IS - 2
M3 - Article
SP - 188
EP - 194
SN - 14346621
AB - Background: Most human metabolomics studies have shown that spectral outputs of 1H nuclear magnetic resonance fingerprinting are strongly influenced by inter- and intra-individual variations; however, few studies have been performed to evaluate the inter- and intra-individual variations in urinary endogenous metabolites. Methods: We recruited 30 male college students to evaluate the factors affecting intra- and inter-individual variations in urinary endogenous metabolites. Statistical analysis for variations in urinary metabolites was performed after eliminating outliers found in principal component analysis (PCA) plots. Results: Inter-individual variations were relatively low for 2-oxoglutarate, succinate, citrate, dimethylglycine, and taurine, but high for trimethylaminoxide (TMAO), hippurate, and lactate. Intra-individual variations for 2-oxoglutarate, citrate, dimethylglycine, and taurine were relatively low, but high for TMAO and hippurate. The factors affecting inter-individual variation of lactate were age, body mass index, beverages, and alcohol, whereas the factors affecting intra-individual variation of lactate were age and fish. Kim Chi intake affected the inter-individual variation of succinate, citrate, TMAO, and hippurate; however, it did not affect the intra-individual variation of endogenous metabolites. Conclusions: Our results showed that inter- and intra-individual variations in urinary endogenous metabolites were very large, and significant factors affecting inter- and intra-individual variation were diverse, even after eliminating outliers in PCA analysis. Clin Chem Lab Med 2009;47:188–94. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Chemistry & Laboratory Medicine is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR magnetic resonance
KW - FINGERPRINTS
KW - METABOLITES
KW - CLINICAL chemistry
KW - BODY mass index
KW - genetic variation
KW - magnetic resonance spectroscopy
KW - metabolism
KW - urine
N1 - Accession Number: 36354799; Mi Park, Eun 1 Lee, Eunil 2; Email Address: eunil@korea.ac.kr Jin Joo, Hyun 3; Email Address: concerto71@sm.ac.kr Oh, Eunha 4 Lee, Joohyun 2 Lee, Ji-Sung 5; Affiliation: 1: Department of Public Health and Division of Brain Korea 21 Project for Biomedical Science, Graduate School of Medicine, Korea University, Seoul, Korea and Department of Public Health Administration, Shin Heung College, Gyeonggi-do, Korea 2: Department of Public Health and Division of Brain Korea 21 Project for Biomedical Science, Graduate School of Medicine, Korea University, Seoul, Korea and Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, Korea University College of Medicine, Seoul, Korea 3: Center for Food and Drug Inspection, Gyeongin Regional Food and Drug Administration, Incheon, Korea 4: Department of Preventive Medicine and Medical Research Center for Environmental Toxico-Genomics and Proteomics, Korea University College of Medicine, Seoul, Korea 5: Division of Biostatistics, Graduate School of Public Health, Korea University, Seoul, Korea; Source Info: Feb2009, Vol. 47 Issue 2, p188; Subject Term: NUCLEAR magnetic resonance; Subject Term: FINGERPRINTS; Subject Term: METABOLITES; Subject Term: CLINICAL chemistry; Subject Term: BODY mass index; Author-Supplied Keyword: genetic variation; Author-Supplied Keyword: magnetic resonance spectroscopy; Author-Supplied Keyword: metabolism; Author-Supplied Keyword: urine; Number of Pages: 7p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1515/CCLM.2009.040
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - ZHIWEI ZHANG
T1 - Estimating a Marginal Causal Odds Ratio Subject to Confounding.
JO - Communications in Statistics: Theory & Methods
JF - Communications in Statistics: Theory & Methods
Y1 - 2009/02//
VL - 38
IS - 3
M3 - Article
SP - 309
EP - 321
SN - 03610926
AB - Odds ratios are frequently used to describe the relationship between a binary treatment or exposure and a binary outcome. An odds ratio can be interpreted as a causal effect or a measure of association, depending on whether it involves potential outcomes or the actual outcome. An odds ratio can also be characterized as marginal versus conditional, depending on whether it involves conditioning on covariates. This article proposes a method for estimating a marginal causal odds ratio subject to confounding. The proposed method is based on a logistic regression model relating the outcome to the treatment indicator and potential confounders. Simulation results show that the proposed method performs reasonably well in moderate-sized samples and may even offer an efficiency gain over the direct method based on the sample odds ratio in the absence of confounding. The method is illustrated with a real example concerning coronary heart disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Communications in Statistics: Theory & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAMPLING (Statistics)
KW - RATIO & proportion
KW - BINARY forms
KW - COMPUTER simulation
KW - Causal inference
KW - Collapsibility
KW - Confounding
KW - Logistic regression
KW - Odds ratio
N1 - Accession Number: 35809189; ZHIWEI ZHANG 1; Email Address: zhiwei.zhang@fda.hhs.gov; Affiliations: 1: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, USA.; Issue Info: Feb2009, Vol. 38 Issue 3, p309; Thesaurus Term: SAMPLING (Statistics); Subject Term: RATIO & proportion; Subject Term: BINARY forms; Subject Term: COMPUTER simulation; Author-Supplied Keyword: Causal inference; Author-Supplied Keyword: Collapsibility; Author-Supplied Keyword: Confounding; Author-Supplied Keyword: Logistic regression; Author-Supplied Keyword: Odds ratio; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1080/03610920802200076
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Haas, David M.
AU - Renbarger, Jamie L.
AU - Denne, Scott
AU - Ahmed, Mahmoud S.
AU - Easterling, Thomas
AU - Feibus, Karen
AU - Meslin, Eric M.
AU - Koren, Gideon
AU - Zajicek, Anne
AU - Snodgrass, Wayne R.
AU - Flockhart, David A.
T1 - Pharmacotherapy and Pregnancy.
JO - CTS: Clinical & Translational Science
JF - CTS: Clinical & Translational Science
Y1 - 2009/02//
VL - 2
IS - 1
M3 - Article
SP - 11
EP - 14
SN - 17528054
AB - The article emphasizes the efficacy of pharmacotherapy in assuring the safety among pregnant women as they take optimum drug doses while minimizing its side effects to them and their unborn babies. The U.S. Food and Drug Administration (FDA)emphasizes the individualization of pharmacotherapy in pregnancy to take individual women under specific surveillance and assistance in taking drugs while minimizing the side effects. The process stresses the involvement of medical practitioners to provide optimal health care to women needing medications in pregnancy.
KW - DRUG utilization
KW - PREGNANT women
KW - ADMINISTRATION of drugs
KW - CHEMICALS -- Physiological effect
KW - DRUG interactions
KW - PREVENTION
KW - PHARMACOLOGY
KW - PREGNANCY
KW - MANAGEMENT
KW - SERVICES for
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36551679; Haas, David M. 1; Email Address: dahaas@iupui.edu Renbarger, Jamie L. 1 Denne, Scott 1 Ahmed, Mahmoud S. 2 Easterling, Thomas 3 Feibus, Karen 4 Meslin, Eric M. 1,5 Koren, Gideon 6 Zajicek, Anne 7 Snodgrass, Wayne R. 2 Flockhart, David A. 1; Affiliation: 1: Indiana University School of Medicine, PREGMED, The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, Indianapolis, Indiana, USA 2: University of Texas Medical Branch, Galveston, Texas, USA 3: University of Washington School of Medicine, Seattle, Washington, USA 4: Food and Drug Administration, Washington, D.C., USA 5: Indiana University Center for Bioethics, Indianapolis, Indiana, USA 6: SickKids Hospital, Motherisk, Toronto, Ontario, Canada, USA 7: National Institute of Child Health and Human Development, Washington, D.C., USA; Source Info: Feb2009, Vol. 2 Issue 1, p11; Subject Term: DRUG utilization; Subject Term: PREGNANT women; Subject Term: ADMINISTRATION of drugs; Subject Term: CHEMICALS -- Physiological effect; Subject Term: DRUG interactions; Subject Term: PREVENTION; Subject Term: PHARMACOLOGY; Subject Term: PREGNANCY; Subject Term: MANAGEMENT; Subject Term: SERVICES for; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Illustrations: 1 Color Photograph; Document Type: Article
L3 - 10.1111/j.1752-8062.2009.00079.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hallman, Mats
AU - Mordenfeld, Arne
AU - Strandkvist, Tomas
T1 - Bone replacement following dental trauma prior to implant surgery – present status.
JO - Dental Traumatology
JF - Dental Traumatology
Y1 - 2009/02//
VL - 25
IS - 1
M3 - Article
SP - 2
EP - 11
SN - 16004469
AB - Dento-alveolar trauma often leads to a need for reconstruction of the alveolar crest before an implant can be placed. Although autogenous bone grafts is considered the ‘gold standard’, this may be associated with patient morbidity and graft resorption. Consequently, the use of bone substitutes has increased. Today, a substantial number of biomaterials are available on the market, but only a few are well documented. The user should be aware that these biomaterials have different properties: resorbable or non-resorbable, time of resorption and resorption mechanism. The purpose of this review is to describe the function of various bone substitutes and indications for their use in reconstructive implant surgery and to give an overview of the current situation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Dental Traumatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALVEOLAR process
KW - BONE growth
KW - OSSEOINTEGRATION
KW - PREOPERATIVE care
KW - GUIDED bone regeneration
N1 - Accession Number: 36174245; Hallman, Mats 1,2,3; Email Address: mats.hallman@lg.se Mordenfeld, Arne 2 Strandkvist, Tomas 2; Affiliation: 1: Department of Oral and Maxillofacial Surgery, Umeå University, Umeå, Sweden 2: Department of Oral and Maxillofacial Surgery, Public Health Service, Gävle, Sweden 3: Center for Research and Development, Uppsala University/Gävleborg County Council, Gävleborg, Sweden; Source Info: Feb2009, Vol. 25 Issue 1, p2; Subject Term: ALVEOLAR process; Subject Term: BONE growth; Subject Term: OSSEOINTEGRATION; Subject Term: PREOPERATIVE care; Subject Term: GUIDED bone regeneration; Number of Pages: 10p; Illustrations: 4 Color Photographs, 3 Charts; Document Type: Article
L3 - 10.1111/j.1600-9657.2008.00690.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36174245&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harth, Erika
AU - Matsuda, Luis
AU - Hernández, Cristina
AU - Rioseco, Maria L.
AU - Romero, Jaime
AU - González-Escalona, Narjol
AU - Martínez-Urtaza, Jaime
AU - Espejo, Romilio T.
T1 - Epidemiology of Vibrio parahaemolyticus Outbreaks, Southern Chile.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/02//
VL - 15
IS - 2
M3 - Article
SP - 163
EP - 168
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Disease outbreaks caused by Vibrio parahaemolyticus in Puerto Montt, Chile, began in 2004 and reached a peak in 2005 at 3,600 clinical cases. Until 2006, every analyzed case was caused by the serovar O3:K6 pandemic strain. In the summer of 2007, only 475 cases were reported; 73% corresponded to the pandemic strain. This decrease was associated with a change in serotype of many pandemic isolates to O3:K59 and the emergence of new clinical strains. One of these strains, associated with 11% of the cases, was genotypically different from the pandemic strain but contained genes that were identical to those found on its pathogenicity island. These findings suggest that pathogenicity-related genes were laterally transferred from the pandemic strain to one of the different V. parahaemolyticus groups comprising the diverse and shifting bacterial population in shellfish in this region. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pandemics
KW - Shellfish
KW - Vibrio parahaemolyticus
KW - Genes
KW - Puerto Montt (Chile)
KW - Chile
N1 - Accession Number: 36576559; Harth, Erika 1; Matsuda, Luis 1; Hernández, Cristina 2; Rioseco, Maria L. 3; Romero, Jaime 1; González-Escalona, Narjol 4; Martínez-Urtaza, Jaime 5; Espejo, Romilio T. 1; Email Address: respejo@inta.cl; Affiliations: 1: Universidad de Chile, Santiago, Chile; 2: Secretaría Regional Ministerial de Salud, Puerto Montt, Chile; 3: Hospital Regional de Puerto Montt, Puerto Montt; 4: Food and Drug Administration, College Park, Maryland, USA; 5: Universidad de Santiago de Compostela, Santiago de Compostela, Spain; Issue Info: Feb2009, Vol. 15 Issue 2, p163; Thesaurus Term: Pandemics; Thesaurus Term: Shellfish; Subject Term: Vibrio parahaemolyticus; Subject Term: Genes; Subject: Puerto Montt (Chile); Subject: Chile; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 6p; Illustrations: 2 Black and White Photographs, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.3201/eid1502.071269
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Silver, Sharon R.
AU - Whelan, Elizabeth A.
AU - Deddens, James A.
AU - Steenland, N. Kyle
AU - Hopf, Nancy B.
AU - Waters, Martha A.
AU - Ruder, Avima M.
AU - Prince, Mary M.
AU - Yong, Lee C.
AU - Hein, Misty J.
AU - Ward, Elizabeth M.
T1 - Occupational Exposure to Polychlorinated Biphenyls and Risk of Breast Cancer.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009/02//
VL - 117
IS - 2
M3 - Article
SP - 276
EP - 282
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Despite the endocrine system activity exhibited by polychlorinated biphenyls (PCBs), recent studies have shown little association between PCB exposure and breast cancer mortality. OBJECTIVES: To further evaluate the relation between PCB exposure and breast cancer risk, we studied incidence, a more sensitive end point than mortality, in an occupational cohort. METHODS: We followed 5,752 women employed for at least 1 year in one of three capacitor manufacturing facilities, identifying cases from questionnaires, cancer registries, and death certificates through 1998. We collected lifestyle and reproductive information via questionnaire from participants or next of kin and used semiquantitative job-exposure matrices for inhalation and dermal exposures combined. We generated standardized incidence ratios (SIRs) and standardized rate ratios and used Cox proportional hazards regression models to evaluate potential confounders and effect modifiers. RESULTS: Overall, the breast cancer SIR was 0.81 (95% confidence interval, 0.72--0.92; n = 257), and regression modeling showed little effect of employment duration or cumulative exposure. However, for the 362 women of questionnaire-identified races other than white, we observed positive, statistically significant associations with employment duration and cumulative exposure; only smoking, birth cohort, and self- or proxy questionnaire completion had statistically significant explanatory power when added to models with exposure metrics. CONCLUSIONS: We found no overall elevation in breast cancer risk after occupational exposure to PCBs. However, the exposure-related risk elevations seen among nonwhite workers, although of limited interpretability given the small number of cases, warrant further investigation, because the usual reproductive risk factors accounted for little of the increased risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Polychlorinated biphenyls
KW - HEALTH
KW - Disease incidence
KW - Cancer in women -- Risk factors
KW - Breast cancer -- Risk factors
KW - Chemicals
KW - PHYSIOLOGICAL effect
KW - Women
KW - breast cancer
KW - incidence
KW - occupational epidemiology
KW - polychlorinated biphenyls
N1 - Accession Number: 36803265; Silver, Sharon R. 1; Email Address: SSilver@cdc.gov; Whelan, Elizabeth A. 1; Deddens, James A. 1; Steenland, N. Kyle 2; Hopf, Nancy B. 3; Waters, Martha A. 1; Ruder, Avima M. 1; Prince, Mary M. 4; Yong, Lee C. 1; Hein, Misty J. 1; Ward, Elizabeth M. 5; Affiliations: 1: National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio, USA; 2: Department of Epidemiology, Emory University School of Public Health, Atlanta, Georgia, USA; 3: Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA; 4: Sanofi-aventis, Bridgewater, New Jersey, USA; 5: American Cancer Society, Atlanta, Georgia, USA; Issue Info: Feb2009, Vol. 117 Issue 2, p276; Thesaurus Term: RESEARCH; Thesaurus Term: Polychlorinated biphenyls; Thesaurus Term: HEALTH; Thesaurus Term: Disease incidence; Subject Term: Cancer in women -- Risk factors; Subject Term: Breast cancer -- Risk factors; Subject Term: Chemicals; Subject Term: PHYSIOLOGICAL effect; Subject Term: Women; Author-Supplied Keyword: breast cancer; Author-Supplied Keyword: incidence; Author-Supplied Keyword: occupational epidemiology; Author-Supplied Keyword: polychlorinated biphenyls; Number of Pages: 7p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105447888
T1 - Occupational exposure to polychlorinated biphenyls and risk of breast cancer.
AU - Silver SR
AU - Whelan EA
AU - Deddens JA
AU - Steenland NK
AU - Hopf NB
AU - Waters MA
AU - Ruder AM
AU - Prince MM
AU - Yong LC
AU - Hein MJ
AU - Ward EM
Y1 - 2009/02//
N1 - Accession Number: 105447888. Language: English. Entry Date: 20090501. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: Supported in part by the Department of Defense Women's Health Research Program (MIPR 94MM4580).. NLM UID: 0330411.
KW - Breast Neoplasms -- Risk Factors
KW - Occupational Exposure -- Adverse Effects
KW - Polychlorinated Biphenyls -- Adverse Effects
KW - Breast Neoplasms -- Epidemiology -- United States
KW - Chi Square Test
KW - Coefficient Alpha
KW - Confidence Intervals
KW - Cox Proportional Hazards Model
KW - Data Analysis Software
KW - Environmental Exposure
KW - Female
KW - Funding Source
KW - Incidence
KW - Middle Age
KW - Prospective Studies
KW - Questionnaires
KW - Registries, Disease
KW - Regression
KW - United States
KW - Human
SP - 276
EP - 282
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 117
IS - 2
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - Background: Despite the endocrine system activity exhibited by polychlorinated biphenyls (PCBs) , recent studies have shown little association between PCB exposure and breast cancer mortality. Objectives: To further evaluate the relation between PCB exposure and breast cancer risk, we studied incidence, a more sensitive end point than mortality, in an occupational cohort. Methods: We followed 5,752 women employed for at least 1 year in one of three capacitor manufacturing facilities, identifying cases from questionnaires, cancer registries, and death certificates through 1998. We collected lifestyle and reproductive information via questionnaire from participants or next of kin and used semiquantitative job-exposure matrices for inhalation and dermal exposures combined. We generated standardized incidence ratios (SIRs) and standardized rate ratios and used Cox proportional hazards regression models to evaluate potential confounders and effect modifiers. Results: Overall, the breast cancer SIR was 0.81 (95% confidence interval, 0.72-0.92 ; n = 257) , and regression modeling showed little effect of employment duration or cumulative exposure. However, for the 362 women of questionnaire-identified races other than white, we observed positive, statistically significant associations with employment duration and cumulative exposure ; only smoking, birth cohort, and self- or proxy questionnaire completion had statistically significant explanatory power when added to models with exposure metrics. Conclusions: We found no overall elevation in breast cancer risk after occupational exposure to PCBs. However, the exposure-related risk elevations seen among nonwhite workers, although of limited interpretability given the small number of cases, warrant further investigation, because the usual reproductive risk factors accounted for little of the increased risk.
SN - 0091-6765
AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226 USA; ssilver@cdc.gov
U2 - PMID: 19270799.
DO - 10.1289/ehp.11774
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Guo, Lei
AU - Li, Quanzhen
AU - Xia, Qingsu
AU - Dial, Stacey
AU - Chan, Po-Chuen
AU - Fu, Peter
T1 - Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2009/02//
VL - 47
IS - 2
M3 - Article
SP - 433
EP - 442
SN - 02786915
AB - Abstract: The association of kava product use with liver-related risks has prompted regulatory action in many countries. We studied the changes in gene expression of drug metabolizing enzymes in the livers of Fischer 344 male rats administered kava extract by gavage for 14 weeks. Analysis of 22,226 genes revealed that there were 14, 41, 110, 386, and 916 genes significantly changed in the 0.125, 0.25, 0.5, 1.0, and 2.0g/kg treatment groups, respectively. There were 16 drug metabolizing genes altered in all three high-dose treatment groups, among which seven genes belong to cytochrome P450 isozymes. While gene expression of Cyp1a1, 1a2, 2c6, 3a1, and 3a3 increased; Cyp 2c23 and 2c40 decreased, all in a dose-dependent manner. Real-time PCR analyses of several genes verified these results. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb–drug interactions and may potentially lead to hepatotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KAVA plant
KW - PLANT extracts
KW - HEPATOTOXICOLOGY
KW - DRUG metabolism
KW - GENE expression
KW - RATS as laboratory animals
KW - DRUGS -- Dose-response relationship
KW - ISOENZYMES
KW - CYTOCHROME P-450
KW - THERAPEUTIC use
KW - Drug metabolizing enzyme
KW - Drug metabolizing gene
KW - Gene expression
KW - Kava extract
KW - Microarray
KW - TaqMan assay
N1 - Accession Number: 36194637; Guo, Lei 1; Email Address: lei.guo@fda.hhs.gov Li, Quanzhen 2 Xia, Qingsu 3 Dial, Stacey 1 Chan, Po-Chuen 4 Fu, Peter 3; Email Address: peter.fu@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Microarray Core Facility UTSW Medical Center, Dallas, TX 75390, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 4: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Source Info: Feb2009, Vol. 47 Issue 2, p433; Subject Term: KAVA plant; Subject Term: PLANT extracts; Subject Term: HEPATOTOXICOLOGY; Subject Term: DRUG metabolism; Subject Term: GENE expression; Subject Term: RATS as laboratory animals; Subject Term: DRUGS -- Dose-response relationship; Subject Term: ISOENZYMES; Subject Term: CYTOCHROME P-450; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Drug metabolizing enzyme; Author-Supplied Keyword: Drug metabolizing gene; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Kava extract; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: TaqMan assay; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.fct.2008.11.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36194637&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Madsen, C.B.
AU - Hattersley, S.
AU - Buck, J.
AU - Gendel, S.M.
AU - Houben, G.F.
AU - Hourihane, J.O’B.
AU - Mackie, A.
AU - Mills, E.N.C.
AU - Nørhede, P.
AU - Taylor, S.L.
AU - Crevel, R.W.R.
T1 - Approaches to risk assessment in food allergy: Report from a workshop ‘‘developing a framework for assessing the risk from allergenic foods”
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2009/02//
VL - 47
IS - 2
M3 - Article
SP - 480
EP - 489
SN - 02786915
AB - Abstract: A workshop was organised to investigate whether risk assessment strategies and methodologies used in classical/conventional toxicology may be used for risk assessment of allergenic foods, to discuss the advantages and limitations of different approaches and to determine the research needed to move the area forward. Three possible approaches to safety assessment and risk assessment for allergenic foods were presented and discussed: safety assessment using NOAEL/LOAEL and uncertainty factors, safety assessment using Benchmark Dose and Margin of Exposure (MoE), and risk assessment using probabilistic models. The workshop concluded that all the three approaches to safety and risk assessment of allergenic foods should continue to be considered. A particular strength of the MoE and probabilistic approaches is that they do not rely on low-dose extrapolations with its inherent issues. Probabilistic modelling is considered to be the most promising approach for use in population risk assessment (which is a particular focus for risk managers). For all approaches, further improvement of input data is desirable, particularly data on consumption patterns/food choices in food allergic consumers, data on minimum eliciting doses and data that can be used to evaluate whether the whole population at risk has been modelled accurately. Specific research topics were identified. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD allergy
KW - HEALTH risk assessment
KW - ALLERGENS
KW - RISK management in business
KW - TOXICOLOGY
KW - MATHEMATICAL models
KW - STATISTICS
KW - Benchmark Dose ( BMD )
KW - double-blind placebo-controlled food challenge ( DBPCFC )
KW - Food allergy
KW - Lowest Observed Adverse Effect Level ( LOAEL )
KW - Margin of Exposure
KW - Margin of Exposure ( MoE )
KW - margin of safety ( MoS )
KW - minimum eliciting dose ( MED )
KW - No Observed Adverse Effect Level ( NOAEL )
KW - Probabilistic
KW - Risk assessment
KW - Uncertainty factors
N1 - Accession Number: 36194643; Madsen, C.B. 1; Email Address: charm@food.dtu.dk Hattersley, S. 2 Buck, J. 2 Gendel, S.M. 3 Houben, G.F. 4 Hourihane, J.O’B. 5 Mackie, A. 6 Mills, E.N.C. 6 Nørhede, P. 1 Taylor, S.L. 7 Crevel, R.W.R. 8; Affiliation: 1: Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Research Leader, 19 Mørkhøj Bygade, DK-2860 Søborg, Denmark 2: Food Standards Agency, London, UK 3: Food and Drug Administration, USA 4: TNO, Quality of Life, Zeist, The Netherlands 5: Department of Paediatrics and Child Health, University College Cork, Ireland 6: Institute of Food Research, Norwich, UK 7: Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska, USA 8: Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, UK; Source Info: Feb2009, Vol. 47 Issue 2, p480; Subject Term: FOOD allergy; Subject Term: HEALTH risk assessment; Subject Term: ALLERGENS; Subject Term: RISK management in business; Subject Term: TOXICOLOGY; Subject Term: MATHEMATICAL models; Subject Term: STATISTICS; Author-Supplied Keyword: Benchmark Dose ( BMD ); Author-Supplied Keyword: double-blind placebo-controlled food challenge ( DBPCFC ); Author-Supplied Keyword: Food allergy; Author-Supplied Keyword: Lowest Observed Adverse Effect Level ( LOAEL ); Author-Supplied Keyword: Margin of Exposure; Author-Supplied Keyword: Margin of Exposure ( MoE ); Author-Supplied Keyword: margin of safety ( MoS ); Author-Supplied Keyword: minimum eliciting dose ( MED ); Author-Supplied Keyword: No Observed Adverse Effect Level ( NOAEL ); Author-Supplied Keyword: Probabilistic; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Uncertainty factors; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.fct.2008.12.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yue Li
AU - Xueya Cai
AU - Glance, Laurent G.
AU - Spector, William D.
AU - Mukamel, Dana B.
T1 - National Release of the Nursing Home Quality Report Cards: Implications of Statistical Methodology for Risk Adjustment.
JO - Health Services Research
JF - Health Services Research
Y1 - 2009/02//
VL - 44
IS - 1
M3 - Article
SP - 79
EP - 102
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To determine how alternative statistical risk-adjustment methods may affect the quality measures (QMs) in nursing home (NH) report cards. Data Sources/Study Settings. Secondary data from the national Minimum Data Set files of 2004 and 2005 that include 605,433 long-term residents in 9,336 facilities. Study Design. We estimated risk-adjusted QMs of decline in activities of daily living (ADL) functioning using classical, fixed-effects, and random-effects logistic models. Risk-adjusted QMs were compared with each other, and with the published QM (unadjusted) in identifying high- and low-quality facilities by either the rankings or 95 percent confidence intervals of QMs. Principal Findings. Risk-adjusted QMs showed better overall agreement (or convergent validity) with each other than did the unadjusted versus each adjusted QM; the disagreement rate between unadjusted and adjusted QM can be as high as 48 percent. The risk-adjusted QM derived from the random-effects shrinkage estimator deviated nonrandomly from other risk-adjusted estimates in identifying the best 10 percent facilities using rankings. Conclusions. The extensively risk-adjusted QMs of ADL decline, even when estimated by alternative statistical methods, show higher convergent validity and provide more robust NH comparisons than the unadjusted QM. Outcome rankings based on ADL decline tend to show lower convergent validity when estimated by the shrinkage estimator rather than other statistical methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities
KW - STATISTICS
KW - REPORT cards
KW - ACTIVITIES of daily living
KW - LOGISTICS
KW - activities of daily living
KW - MDS
KW - Nursing home
KW - quality report cards
KW - risk adjustment
N1 - Accession Number: 36089989; Yue Li 1; Email Address: ylill@uci.edu Xueya Cai 2 Glance, Laurent G. 3 Spector, William D. 4 Mukamel, Dana B. 5; Affiliation: 1: Department of Medicine, University of California, Irvine, CA 92697 2: Division of Biostatistics, Indiana University School of Medicine, Indiana University Purdue University Indianapolis, Indianapolis, IN 3: Department of Anesthesiology, The University of Rochester School of Medicine and Dentistry, Rochester, NY 4: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, M.D. 5: Center for Health Policy Research, University of California, Irvine, CA; Source Info: Feb2009, Vol. 44 Issue 1, p79; Subject Term: NURSING care facilities; Subject Term: STATISTICS; Subject Term: REPORT cards; Subject Term: ACTIVITIES of daily living; Subject Term: LOGISTICS; Author-Supplied Keyword: activities of daily living; Author-Supplied Keyword: MDS; Author-Supplied Keyword: Nursing home; Author-Supplied Keyword: quality report cards; Author-Supplied Keyword: risk adjustment; NAICS/Industry Codes: 541614 Process, Physical Distribution, and Logistics Consulting Services; NAICS/Industry Codes: 623310 Community care facilities for the elderly; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); Number of Pages: 24p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2008.00910.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sahakian, N.
AU - Park, J.-H.
AU - Cox-Ganser, J.
T1 - Respiratory Morbidity and Medical Visits Associated with Dampness and Air-conditioning in Offices and Homes.
JO - Indoor Air
JF - Indoor Air
Y1 - 2009/02//
VL - 19
IS - 1
M3 - Article
SP - 58
EP - 67
PB - Wiley-Blackwell
SN - 09056947
AB - We used data from 4345 adult US residents who were part of a 2004 national random mail survey to investigate associations between dampness and air-conditioning (AC) in homes and offices, and health outcomes, sick leave due to respiratory symptoms and medical visits during the past 12 months. We identified from this group 1396 office workers employed in professional, executive, administrative, managerial or administrative support occupations. Office workers reporting home dampness had an elevated prevalence of nasal symptoms [prevalence ratio (PR) = 1.4, P = 0.01] and constitutional symptoms (PR = 1.3, P = 0.01) in the previous year. Office workers reporting workplace dampness had an elevated prevalence of sick leave attributed to respiratory symptoms (PR = 1.3, P = 0.04) in the previous year. Office workers with home AC were more likely to have visited a medical specialist in the previous year (PR = 1.3, P = 0.02). We did not find any statistically significant associations between workplace AC and any of the health outcomes. We estimated an annual cost of US$1.4 billion for excess respiratory-related sick leave among office workers with workplace dampness. Our study strengthens the evidence of a relationship between dampness and health effects, and highlights the resulting economic impact. Practical Implications This study adds to the literature on respiratory morbidity associated with home and office exposures to mold and dampness. Public health response to lessen these exposures will improve the health and well-being of residents and workers as well as diminish the economic burden of lost work time and medical costs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dampness in buildings
KW - Air conditioning
KW - Mail surveys
KW - Sick leave
KW - Respiratory organs
KW - United States
KW - Air-conditioning
KW - Asthma
KW - Healthcare visits
KW - Indoor air quality
KW - Mold
KW - Office buildings
KW - Respiratory symptoms
KW - Ventilation
N1 - Accession Number: 36142504; Sahakian, N. 1; Email Address: nsahakian@cdc.gov; Park, J.-H. 1; Cox-Ganser, J. 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA; Issue Info: Feb2009, Vol. 19 Issue 1, p58; Thesaurus Term: Dampness in buildings; Thesaurus Term: Air conditioning; Subject Term: Mail surveys; Subject Term: Sick leave; Subject Term: Respiratory organs; Subject: United States; Author-Supplied Keyword: Air-conditioning; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Healthcare visits; Author-Supplied Keyword: Indoor air quality; Author-Supplied Keyword: Mold; Author-Supplied Keyword: Office buildings; Author-Supplied Keyword: Respiratory symptoms; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 811412 Appliance Repair and Maintenance; NAICS/Industry Codes: 221330 Steam and Air-Conditioning Supply; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; Number of Pages: 10p; Illustrations: 9 Charts; Document Type: Article
L3 - 10.1111/j.1600-0668.2008.00561.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Laney, A. S.
AU - Cragin, L. A.
AU - Blevins, L. Z.
AU - Sumner, A. D.
AU - Cox-Ganser, J. M.
AU - Kreiss, K.
AU - Moffatt, S. G.
AU - Lohff, C. J.
T1 - Sarcoidosis, asthma, and asthma-like symptoms among occupants of a historically water-damaged office building.
JO - Indoor Air
JF - Indoor Air
Y1 - 2009/02//
VL - 19
IS - 1
M3 - Article
SP - 83
EP - 90
PB - Wiley-Blackwell
SN - 09056947
AB - Sarcoidosis is a granulomatous disease of unknown etiology with evidence of association with exposure to microbial agents. In June 2006, we investigated a sarcoidosis cluster among office workers in a water-damaged building. In the course of the investigation, we became aware of a high rate of respiratory complaints including asthma and asthma-like symptoms. We conducted case finding for physician-diagnosed sarcoidosis and asthma and administered a health questionnaire survey and pulmonary function tests (PFTs) to consenting occupants. We compared prevalence ratios (PRs) to the Environmental Protection Agency’s Building Assessment Survey and Evaluation study (BASE) and the National Health and Nutrition Examination Survey (NHANES). We identified six sarcoidosis cases. The current building prevalence is 2206 cases/100,000 population, elevated, compared with the US population range of <1–40 cases/100,000. Of current occupants, 77% (105) participated in the health questionnaire survey and 64% (87) in PFTs. Physician-diagnosed asthma was elevated, compared with the US adult population. Adult asthma incidence was 3.3/1000 person-years during the period before building occupancy and 11.5/1000 person-years during the period after building occupancy. Comparisons with US office workers (BASE) yielded elevated PRs for shortness of breath [PR, 9.6; 95% confidence interval (CI), 6.1–15.2], wheeze (PR, 9.1; 95% CI 5.6–14.6), and chest tightness (PR, 5.1; 95% CI 2.8–9.0). PFT results supported reports of respiratory symptoms and diagnoses. Based on our findings building occupants were relocated. Practical Implications The remission of occupational asthma caused by certain known antigens improves with early diagnosis and removal from exposure. As a suspected antigen-mediated disease, sarcoidosis might also benefit if affected persons are isolated from continued exposure. Our investigation identified a high prevalence of new-onset sarcoidosis, and asthma among workers of a water damaged building with a history of indoor environmental quality complaints. Removal of all individuals from such environments until completion of building diagnostics, environmental sampling and complete remediation is a prudent measure when feasible. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases -- Causes & theories of causation
KW - Asthma
KW - Office buildings
KW - Sarcoidosis
KW - Chronic granulomatous disease
KW - Symptoms
KW - Building-related symptoms
KW - Indoor environment
KW - Office workers
N1 - Accession Number: 36142501; Laney, A. S. 1,2; Email Address: aol4@cdc.gov; Cragin, L. A. 1; Blevins, L. Z. 1,3; Sumner, A. D. 1; Cox-Ganser, J. M. 4; Kreiss, K. 4; Moffatt, S. G. 1; Lohff, C. J. 1; Affiliations: 1: Division of Health Surveillance, Vermont Department of Health, Burlington, VT, USA; 2: Epidemic Intelligence Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA; 3: Coordinating Office for Terrorism Preparedness and Emergency Response, CDC, Atlanta, GA, USA; 4: National Institute for Occupational Safety and Health, Morgantown, WV, USA; Issue Info: Feb2009, Vol. 19 Issue 1, p83; Thesaurus Term: Diseases -- Causes & theories of causation; Thesaurus Term: Asthma; Thesaurus Term: Office buildings; Subject Term: Sarcoidosis; Subject Term: Chronic granulomatous disease; Subject Term: Symptoms; Author-Supplied Keyword: Building-related symptoms; Author-Supplied Keyword: Indoor environment; Author-Supplied Keyword: Office workers; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; Number of Pages: 8p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2008.00564.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36142501&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Pierik, Frank H.
AU - Deddens, James A.
AU - Burdorf, Alex
AU - de Muinck Keizer-Schrama, Sabine M. P. F.
AU - de Jong, Frank H.
AU - Weber, Rob F. A.
T1 - Response: the hypothalamus–pituitary–testis axis in cryptorchid boys.
JO - International Journal of Andrology
JF - International Journal of Andrology
Y1 - 2009/02//
VL - 32
IS - 1
M3 - Letter
SP - 90
EP - 90
PB - Wiley-Blackwell
SN - 01056263
AB - A letter to the editor is presented in response to the article about hypothalamus-pituitary-testis axis in cryptorchid boys in the previous issue.
KW - LETTERS to the editor
KW - CRYPTORCHISM
N1 - Accession Number: 35922835; Pierik, Frank H. 1; Email Address: frank.pierik@tno.nl Deddens, James A. 2 Burdorf, Alex 1 de Muinck Keizer-Schrama, Sabine M. P. F. 3 de Jong, Frank H. 4 Weber, Rob F. A. 5; Affiliation: 1: Department of Public Health, Erasmus MC, Rotterdam, The Netherlands 2: National Institute for Occupational Safety and Health, Cincinnati, OH, USA 3: Department of Pediatric Endocrinology, Erasmus MC 4: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands 5: Department of Andrology, Erasmus MC; Source Info: Feb2009, Vol. 32 Issue 1, p90; Subject Term: LETTERS to the editor; Subject Term: CRYPTORCHISM; Number of Pages: 1p; Document Type: Letter
L3 - 10.1111/j.1365-2605.2008.00912.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yang, Baowei
AU - Zheng, Jie
AU - Brown, Eric W.
AU - Zhao, Shaohua
AU - Meng, Jianghong
T1 - Characterisation of antimicrobial resistance-associated integrons and mismatch repair gene mutations in Salmonella serotypes
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
Y1 - 2009/02//
VL - 33
IS - 2
M3 - Article
SP - 120
EP - 124
SN - 09248579
AB - Abstract: In this study, we examined the presence of integrons and Salmonella genomic island 1 (SGI1) and assessed their contribution to antimicrobial resistance as well as determining the extent of the mutator phenotype in Salmonella isolates. A total of 81 Salmonella enterica serotype Typhimurium isolates were examined for the presence of integrons and SGI1 and for hypermutators using polymerase chain reaction (PCR) and the mutator assay, respectively. An additional 336 Salmonella isolates were also used to screen for hypermutators. Fourteen S. Typhimurium isolates carried class 1 integrons, of which six were shown to possess SGI1. Five putative mutators, S. Typhimurium ST20751, S. enterica serotype Heidelberg 22396 and S. enterica serotype Enteritidis 17929, 17929N and 17929R, were identified among the 417 Salmonella isolates. Complementation analysis with the wild-type mutH, mutL, mutS and uvrD genes indicated that none of the five mutators contained defective mismatch repair (MMR) system alleles. DNA sequence analysis revealed that single point mutations resulting in aspartic acid (codon 87) substitution in the gyrA gene conferred resistance to nalidixic acid and/or other fluoroquinolone drugs (ciprofloxacin and enrofloxacin) among four isolates. Our findings indicated that integrons and SGI1 play an important role in multidrug resistance in Salmonella. The incidence of hypermutators owing to defective MMR in Salmonella appears to be rare. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Antimicrobial Agents is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Salmonella
KW - Genotype-environment interaction
KW - Polymerase chain reaction
KW - Antimicrobial resistance
KW - Integron
KW - Mutation
N1 - Accession Number: 36061323; Yang, Baowei 1; Zheng, Jie 2; Brown, Eric W. 3; Zhao, Shaohua 4; Meng, Jianghong 2; Email Address: jmeng@umd.edu; Affiliations: 1: College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China; 2: Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; 3: Division of Microbiological Studies, Office of Plant and Dairy Foods, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA; 4: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD, USA; Issue Info: Feb2009, Vol. 33 Issue 2, p120; Thesaurus Term: Anti-infective agents; Thesaurus Term: Salmonella; Thesaurus Term: Genotype-environment interaction; Subject Term: Polymerase chain reaction; Author-Supplied Keyword: Antimicrobial resistance; Author-Supplied Keyword: Integron; Author-Supplied Keyword: Mutation; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijantimicag.2008.08.016
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kulkarni, Pramod
AU - Deye, Gregory J.
AU - Baron, Paul A.
T1 - Bipolar diffusion charging characteristics of single-wall carbon nanotube aerosol particles
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
Y1 - 2009/02//
VL - 40
IS - 2
M3 - Article
SP - 164
EP - 179
SN - 00218502
AB - Abstract: Bipolar diffusion charging characteristics of airborne single-wall carbon nanotube (SWCNT) agglomerates were investigated in the mobility diameter range of 100–1000nm. Neutral fractions of three types of SWCNT aerosols following bipolar charge equilibrium in a radioactive source were experimentally measured to infer their electrical charging characteristics. Significant deviation from Boltzmann and Fuchs stationary charge equilibrium was observed, with neutral fractions of SWCNT particles lower by 30–53% compared to that of spherical particles of the same mobility. Particles with mobility diameter larger than 400nm showed high electrical charging efficiencies compared to that of mobility-equivalent spherical particles. Higher charging efficiencies of SWCNT particles were attributed to their higher electrical capacitance resulting from complex nonspherical morphologies. Numerical calculations using idealized fiber geometries confirmed the qualitative trend in the experimental data. The electrical capacitance of nanotubes particles deduced from experimentally measured neutral fractions were also found to be higher by a factor ranging from 1.6 to 4.6 compared to that of mobility-equivalent spherical particles, indicating high charge carrying capacity. The charging-equivalent diameters of nanotube particles were computed and were found to be higher than their mobility diameter by a factor of 2.85–4.34. [Copyright &y& Elsevier]
AB - Copyright of Journal of Aerosol Science is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOLUTION (Chemistry)
KW - MATTER -- Properties
KW - SOLID solutions
KW - SEMICONDUCTOR doping
KW - Diffusion charging
KW - Single-wall carbon nanotubes
N1 - Accession Number: 36194229; Kulkarni, Pramod; Email Address: PSKulkarni@cdc.gov Deye, Gregory J. 1 Baron, Paul A. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS: R-3, Cincinnati, OH 45225, USA; Source Info: Feb2009, Vol. 40 Issue 2, p164; Subject Term: SOLUTION (Chemistry); Subject Term: MATTER -- Properties; Subject Term: SOLID solutions; Subject Term: SEMICONDUCTOR doping; Author-Supplied Keyword: Diffusion charging; Author-Supplied Keyword: Single-wall carbon nanotubes; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.jaerosci.2008.09.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Myong-Jin Kim
AU - Shiew-Mei Huang
AU - Meyer, Urs A.
AU - Rahman, Atiqur
AU - Lesko, Lawrence J.
T1 - A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2009/02//
VL - 49
IS - 2
M3 - Article
SP - 138
EP - 146
SN - 00912700
AB - Warfarin is a challenging drug to accurately dose, both initially and for maintenance, because of its narrow therapeutic range, wide interpatient variability, and long list of factors that can influence dosing. Two million people in the United States are initiated on warfarin therapy annually, and this number is steadily increasing because of the increase in number of eligible patients. Recently, warfarin was reported to be the fourth leading cause of adverse events. The U.S. Food and Drug Administration recognizes that the adverse event rate of warfarin can be improved through better initial dosing, because many of the serious adverse events of warfarin occur soon after starting treatment. A substantial number of studies demonstrate that common variants of two genes, VKORC1 and CYP2C9, along with other nongenetic factors, correlate significantly with warfarin dosing. The genotypes of VKORC1 and CYP2C9 alone account for nearly 3 times more of the variability (∼30%) in warfarin dosing than do age, weight, gender, and other clinical factors combined (∼12%). Therefore, the purpose of this report is to review the current recommendations for warfarin therapy that involve genetic testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WARFARIN
KW - PHARMACOGENOMICS
KW - HUMAN chromosome abnormalities -- Diagnosis
KW - DOSAGE of drugs
KW - UNITED States
KW - CYP2C9
KW - pharmacogenetics
KW - VKORC1
KW - Warfarin
N1 - Accession Number: 36313066; Myong-Jin Kim 1 Shiew-Mei Huang 1; Email Address: shiewmei.huang@fda.hhs.gov Meyer, Urs A. 1 Rahman, Atiqur 1 Lesko, Lawrence J. 1; Affiliation: 1: Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Source Info: Feb2009, Vol. 49 Issue 2, p138; Subject Term: WARFARIN; Subject Term: PHARMACOGENOMICS; Subject Term: HUMAN chromosome abnormalities -- Diagnosis; Subject Term: DOSAGE of drugs; Subject Term: UNITED States; Author-Supplied Keyword: CYP2C9; Author-Supplied Keyword: pharmacogenetics; Author-Supplied Keyword: VKORC1; Author-Supplied Keyword: Warfarin; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1177/0091270008328098
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36313066&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105644734
T1 - A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity.
AU - Kim M
AU - Huang S
AU - Meyer UA
AU - Rahman A
AU - Lesko LJ
Y1 - 2009/02//
N1 - Accession Number: 105644734. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts; website. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 0366372.
KW - Dosage Calculation
KW - Genetic Screening
KW - Warfarin -- Pharmacodynamics
KW - Warfarin -- Pharmacokinetics
KW - Warfarin -- Therapeutic Use
KW - International Normalized Ratio
KW - Meta Analysis
KW - Warfarin -- Adverse Effects
KW - World Wide Web
SP - 138
EP - 146
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 49
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Warfarin is a challenging drug to accurately dose, both initially and for maintenance, because of its narrow therapeutic range, wide interpatient variability, and long list of factors that can influence dosing. Two million people in the United States are initiated on warfarin therapy annually, and this number is steadily increasing because of the increase in number of eligible patients. Recently, warfarin was reported to be the fourth leading cause of adverse events. The U.S. Food and Drug Administration recognizes that the adverse event rate of warfarin can be improved through better initial dosing, because many of the serious adverse events of warfarin occur soon after starting treatment. A substantial number of studies demonstrate that common variants of two genes, VKORC1 and CYP2C9, along with other nongenetic factors, correlate significantly with warfarin dosing. The genotypes of VKORC1 and CYP2C9 alone account for nearly 3 times more of the variability ( approximately 30%) in warfarin dosing than do age, weight, gender, and other clinical factors combined ( approximately 12%). Therefore, the purpose of this report is to review the current recommendations for warfarin therapy that involve genetic testing.
SN - 0091-2700
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Rm 3188, Bldg 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002; e-mail: shiewmei.huang@fda.hhs.gov.
U2 - PMID: 19179293.
DO - 10.1177/0091270008328098
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105644734&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Michael Keane
AU - Samuel Stone
AU - Bean Chen
AU - James Slaven
AU - Diane Schwegler-Berry
AU - James Antonini
T1 - Hexavalent chromium content in stainless steel welding fumes is dependent on the welding process and shield gas typeDisclaimer: The findings and conclusions in this paper are those of the author and do not necessarily represent the views of the National Institute for Occupational Safety and Health. The mention of any company names or products does not imply an endorsement by NIOSH or the Centers for Disease Control and Prevention, nor does it imply that alternative products are unavailable, or unable to be substituted after appropriate evaluation
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2009/02//
VL - 11
IS - 2
M3 - Article
SP - 418
EP - 424
SN - 14640325
AB - Occupational exposure to welding fumes is a known health hazard. To isolate elements in stainless steel welding fumes with high potential for adverse health outcomes, fumes were generated using a robotic gas metal arc system, using four shield gases of varying oxygen content. The objective was to measure CrVIconcentrations in a broad spectrum of gas metal arc welding processes, and identify processes of exceptionally high or low CrVIcontent. The gases used were 95% Ar/5% O2, 98% Ar/2% O2, 95% Ar/5%CO2, and 75% He/25% Ar. The welder was operated in axial spray mode (Ar/O2, Ar/CO2), short-circuit (SC) mode (Ar/CO2low voltage and He/Ar), and pulsed axial-spray mode (98% Ar/2% O2). Results indicate large differences in CrVIin the fumes, with Ar/O2(Pulsed) > Ar/O2> Ar/CO2> Ar/CO2(SC) > He/Ar; values were 3000 ± 300, 2800 ± 85, 2600 ± 120, 1400 ± 190, and 320 ± 290 ppm respectively (means ± standard errors for 2 runs and 3 replicates per run). Respective rates of CrVIgeneration were 1.5, 3.2, 4.4, 1.3, and 0.46 µg/min; generation rates were also calculated in terms of µg CrVIper metre of wire used. The generation rates of CrVIincreased with increasing O3concentrations. Particle size measurements indicated similar distributions, but somewhat higher >0.6 µm fractions for the short-circuit mode samples. Fumes were also sampled into 2 selected size ranges, a microspatter fraction (≥0.6 µm) and a fine (<0.6 µm) fraction; analysis indicated that CrVIis primarily associated with particles <0.6 µm. The conclusion of the study is that CrVIconcentrations vary significantly with welding type and shield gas type, and this presents an opportunity to tailor welding practices to lessen CrVIexposures in workplaces by selecting low CrVI-generating processes. Short-circuit processes generated less CrVIthan axial-spray methods, and inert gas shielding gave lower CrVIcontent than shielding with active gases. A short circuit He/Ar shielded process and a pulsed axial spray Ar/O2process were both identified as having substantially lower CrVIgeneration rates per unit of wire used relative to the other processes studied. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chromium group
KW - Health risk assessment
KW - Electric welding
KW - Corrosion resistant alloys
N1 - Accession Number: 36462343; Michael Keane 1; Samuel Stone 1; Bean Chen 1; James Slaven 1; Diane Schwegler-Berry 1; James Antonini 1; Affiliations: 1: National Institute for Occupational Safety and Health; Issue Info: Feb2009, Vol. 11 Issue 2, p418; Thesaurus Term: Chromium group; Thesaurus Term: Health risk assessment; Subject Term: Electric welding; Subject Term: Corrosion resistant alloys; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Martin Harper
AU - James E. Slaven
AU - Thomas W. S. Pang
T1 - Continued participation in an asbestos fiber-counting proficiency test with relocatable grid slidesErratum: In our previous paper we had reported that asbestos filters from the Proficiency Analytical Test program of the American Industrial Hygiene Association (AIHA) were produced from air-generated asbestos. This is in fact not the case; these filters have always been generated from deposition of a liquid slurry, and the “REF” slides described above are made from these filters. The materials used in the Asbestos Analytical Test program of the AIHA's Asbestos Analysts Registry (AAR) were made from air-generated samples, but these also have been generated from liquid slurry deposition since 2006.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2009/02//
VL - 11
IS - 2
M3 - Article
SP - 434
EP - 438
SN - 14640325
AB - The effect of using relocatable reference slides of chrysotile and amosite in asbestos fiber counting proficiency testing was examined for volunteer analysts from laboratories in the USA. Results of participation in one round have been published; two more rounds are reported here. In the first round, participants were asked to draw what they saw, allowing identification of error type by comparison to the reference. In later rounds only the number of fibers per field was reported since the number of errors per field has been shown to be a reasonable estimate of proficiency. The third round included a training exercise. The total number of participants stayed reasonably constant with some reduction over time. More restricted numbers participated from round to round. Those who dropped out had lower average scores than those that remained in the program; from 2006 to 2007 this difference was significant, but for 2007 to 2008 it was not. The overall results for amosite were generally good compared to an arbitrary proficiency score of 60, and continued to improve further over time. The results for chrysotile were better in rounds 1 and 3 than round 2, so that both attention to detail (drawing the fibers in round 1) and training (round 3) may improve performance, which is consistent with the major type of error being oversight of fine fibers. However, the results are still poor, even by round 3, and no analyst achieved a score of 60 in all three rounds. Further improvement is preferred since chrysotile is the most commonly encountered type of asbestos in the USA. Depending on the adopted score for proficiency many laboratories or analysts may be labeled as poor performers and this may be a deterrent to voluntary participation in this type of exercise, especially for those in most need of assistance. Participants have tested new relocatable reference asbestos proficiency counting slides in three rounds of chrysotile and three rounds of amosite. Performance for amosite was good. Poor performance for chrysotile appears to be improved by greater attention and training. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestos
KW - Industrial hygiene
KW - Environmental health
KW - Occupational medicine
N1 - Accession Number: 36462342; Martin Harper 1; James E. Slaven 1; Thomas W. S. Pang 2; Affiliations: 1: National Institute for Occupational Safety and Health; 2: c/o Ryerson University; Issue Info: Feb2009, Vol. 11 Issue 2, p434; Thesaurus Term: Asbestos; Thesaurus Term: Industrial hygiene; Thesaurus Term: Environmental health; Subject Term: Occupational medicine; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YANG CAO
AU - CALAFAT, ANTONIA M.
AU - DOERGE, DANIEL R.
AU - UMBACH, DAVID M.
AU - BERNBAUM, JUDY C.
AU - TWADDLE, NATHAN C.
AU - XIAOYUN YE
AU - ROGAN, WALTER J.
T1 - Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2009/02//
VL - 19
IS - 2
M3 - Article
SP - 223
EP - 234
PB - Nature Publishing Group
SN - 15590631
AB - In the United States, about 25% of infant formula sold is based on soy protein, which is an important source of estrogenic isoflavones in the human food supply. Nevertheless, few studies report isoflavone levels in infants. We did a partly cross-sectional and partly longitudinal pilot study to examine children's exposure to isoflavones from different feeding methods. A total of 166 full-term infants between birth and 1 year of age were recruited into soy formula, cow milk formula, or breast milk regimens according to their feeding histories. A total of 381 urine, 361 saliva, and 88 blood samples were collected at 382 visits. We used automated online solid-phase extraction coupled to high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) for measuring three isoflavones (daidzein, genistein, and equol) in urine, and used similar LC/MS/MS techniques for saliva and blood spots. Concentrations of daidzein and genistein were undetectable in most blood or saliva samples from children fed breast milk or cow milk formula. The proportion of non-detectable values was somewhat lower in urine than in the other matrices. Concentrations of equol were detectable only in a few urine samples. For both daidzein and genistein, urine contained the highest median concentrations, followed by blood and then saliva. Urinary concentrations of genistein and daidzein were about 500 times higher in the soy formula-fed infants than in the cow milk formula-fed infants. The correlations between matrices for either analyte were strikingly lower than the correlation between the two analytes in any single matrix. We did not find significant correlations between isoflavone concentrations and the levels of certain hormones in children fed soy formula. Our results, based on much larger numbers of infants, strongly confirm previous reports, but whether phytoestrogens in soy formula are biologically active in infants is still an open question. We plan further longitudinal studies focusing on physical and developmental findings reflecting the effects of estrogen exposure.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 223–234; doi:10.1038/jes.2008.44; published online 30 July 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFANT formulas
KW - SOY proteins
KW - ISOFLAVONES
KW - RESEARCH
KW - UNITED States
KW - daidzein
KW - genistein
KW - infant feeding
KW - isoflavone
KW - phytoestrogen
KW - soy formula
N1 - Accession Number: 36113349; YANG CAO 1 CALAFAT, ANTONIA M. 2 DOERGE, DANIEL R. 3 UMBACH, DAVID M. 4 BERNBAUM, JUDY C. 3 TWADDLE, NATHAN C. 3 XIAOYUN YE 2 ROGAN, WALTER J. 1; Email Address: rogan@niehs.nih.gov; Affiliation: 1: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA 2: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA 4: Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA; Source Info: Feb2009, Vol. 19 Issue 2, p223; Subject Term: INFANT formulas; Subject Term: SOY proteins; Subject Term: ISOFLAVONES; Subject Term: RESEARCH; Subject Term: UNITED States; Author-Supplied Keyword: daidzein; Author-Supplied Keyword: genistein; Author-Supplied Keyword: infant feeding; Author-Supplied Keyword: isoflavone; Author-Supplied Keyword: phytoestrogen; Author-Supplied Keyword: soy formula; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; Number of Pages: 12p; Illustrations: 1 Black and White Photograph, 7 Charts, 5 Graphs; Document Type: Article
L3 - 10.1038/jes.2008.44
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - EUNKYOUNG SEO
AU - YOHAN YOON
AU - KYEONGYEOL KIM
AU - WON-BO SHIM
AU - NINA KUZMINA
AU - KEUM-SOON OH
AU - JONG-OK LEE
AU - JUNGHYUCK SUH
AU - SOO-HYUNG LEE
AU - KEE-HEY CHUNG
AU - DUCK-HWA CHUNG
AU - DONG-SUL KIM
T1 - Fumonisins B1 and B2 in Agricultural Products Consumed in South Korea: An Exposure Assessment.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/02//
VL - 72
IS - 2
M3 - Article
SP - 436
EP - 440
SN - 0362028X
AB - To survey fumonisins B1 (FB1) and B2 (FB1) in agricultural products consumed in South Korea and provide an exposure assessment, ground samples were extracted (80% MeOH), filtered (0.2 µm), and cleaned up. After evaporation, dry residues were reconstituted in 50% MeOH, and a 50-µl aliquot of this sample was mixed with 200 µ1 of o-phthaldialdehyde for derivatization. The derivatives were analyzed with a high-performance liquid chromatography system equipped with a fluorescence detector. For validation of the detection procedure, linearity, accuracy, precision, detection limit, and quantification limit were determined. The validated detection method was then used to survey fumonisins in white rice, brown rice, barley, barley tea, beer, wheat flour, millet, dried corn, corn flour, corn tea, canned corn, popcorn, and breakfast cereal. Retention times for FB1 and FB2 standards were 7 and 18 min, respectively. Linearity (R² = 0.99995 to 0.99998), accuracy (81.47 to 108.83%), precision (2.35 to 5.77), detection limit (25 ng/g or ng/ml), and quantification limit (37 ng/g or ng/ml) indicated that this procedure is capable of quantifying fumonisins in agricultural products. Only FB1-positive samples (5.12%, three dried corn samples and five corn flour samples) were found at 90.89 to 439.67 ng/g. According the survey results, an estimated daily intake of FB1 and FB2 in Korea was 0.087 ng/kg of body weight per day. These results indicate that continuous monitoring of these mycotoxins is necessary to establish appropriate risk assessment, and the maximum tolerable daily intake of fumonisins in Korea is lower than the 2 µg/kg set by the Joint Food and Agriculture Organization-World Health Organization Expert Committee. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Farm produce
KW - Liquid chromatography
KW - Mycotoxins
KW - Fumonisins
KW - Korea (South)
N1 - Accession Number: 36808200; EUNKYOUNG SEO 1; YOHAN YOON 1; KYEONGYEOL KIM 1; WON-BO SHIM 1; NINA KUZMINA 1; KEUM-SOON OH 2; JONG-OK LEE 2; JUNGHYUCK SUH 2; SOO-HYUNG LEE 3; KEE-HEY CHUNG 4; DUCK-HWA CHUNG 1; Email Address: dhchung@gnu.ac.kr; DONG-SUL KIM 2; Affiliations: 1: Division of Applied Life Science, Graduate School of Gyeongsang National University, Jinju, Gyeongnam 660-701, Korea; 2: Department of Food Evaluation, Korea Food and Drug Administration, Seoul 122-704, Korea; 3: Hazardous Substances Division, National Institute of Agricultural Science and Technology, Rural Development Administration, Suwon, Gyeonggi 441-707, Korea; 4: Headquarters for Health Policy Research/Food and Nutrition Policy Team, Korea Institute for Health and Social Affair, Seoul 122-705, Korea; Issue Info: Feb2009, Vol. 72 Issue 2, p436; Thesaurus Term: Farm produce; Thesaurus Term: Liquid chromatography; Thesaurus Term: Mycotoxins; Subject Term: Fumonisins; Subject: Korea (South); NAICS/Industry Codes: 424590 Other Farm Product Raw Material Merchant Wholesalers; NAICS/Industry Codes: 493130 Farm Product Warehousing and Storage; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hellinger, Fred Joseph
T1 - Tax-Exempt Hospitals and Community Benefits: A Review of State Reporting Requirements.
JO - Journal of Health Politics, Policy & Law
JF - Journal of Health Politics, Policy & Law
Y1 - 2009/02//
VL - 34
IS - 1
M3 - Article
SP - 37
EP - 61
PB - Duke University Press
SN - 03616878
AB - In June 2007 the Internal Revenue Service proposed a major overhaul of its reporting requirements for tax-exempt hospitals and released draft Form 990 (the IRS form filed by tax-exempt organizations each year). In December 2007 the IRS promulgated the final Form 990 after incorporating some of the recommendations made in the almost seven hundred public comments on the discussion draft. One recommendation adopted in the final Form 990 is the postponement until tax year 2009 (returns filed in 2010) of the requirement for hospitals to submit detailed information on the percentage of total expenses attributable to charity care, unreimbursed Medicaid costs, and community-health improvement programs (the discussion draft required this information for tax year 2007). Although the IRS will not require taxexempt hospitals to provide detailed information about community benefits until the 2009 tax year, sixteen states have laws requiring tax-exempt hospitals to enumerate the benefits that they provide to the community. Information about the impact of these laws on the provision of community benefits (e.g., charity and uncompensated care) is examined in this study whose primary purpose is to highlight information policy makers may glean from states that have adopted community-benefit reporting laws. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Politics, Policy & Law is the property of Duke University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HOSPITALS
KW - GOVERNMENT policy
KW - TAX exemption
KW - TAXATION -- Law & legislation
KW - INTERNAL revenue law
KW - MEDICAL care costs
KW - UNITED States
KW - UNITED States. Internal Revenue Service
N1 - Accession Number: 36617080; Hellinger, Fred Joseph 1; Affiliation: 1: Agency for Healthcare Research and Quality.; Source Info: Feb2009, Vol. 34 Issue 1, p37; Subject Term: HOSPITALS; Subject Term: GOVERNMENT policy; Subject Term: TAX exemption; Subject Term: TAXATION -- Law & legislation; Subject Term: INTERNAL revenue law; Subject Term: MEDICAL care costs; Subject Term: UNITED States; Company/Entity: UNITED States. Internal Revenue Service; NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 25p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105470198
T1 - Tax-exempt hospitals and community benefits: a review of state reporting requirements [corrected] [published erratum appears in J HEALTH POLIT POLICY LAW 2009 Apr;34(2):297].
AU - Hellinger FJ
Y1 - 2009/02//
N1 - Accession Number: 105470198. Language: English. Entry Date: 20090703. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 7609331.
KW - Community-Institutional Relations
KW - Hospitals -- Economics
KW - Mandatory Reporting
KW - Organizations, Nonprofit
KW - Taxes -- Legislation and Jurisprudence -- United States
KW - American Hospital Association
KW - Government Regulations
KW - Health Policy
KW - Hospitals, Community
KW - Joint Ventures -- Legislation and Jurisprudence -- United States
KW - Organizational Efficiency
KW - Uncompensated Care
KW - United States
SP - 37
EP - 61
JO - Journal of Health Politics, Policy & Law
JF - Journal of Health Politics, Policy & Law
JA - J HEALTH POLIT POLICY LAW
VL - 34
IS - 1
CY - Durham, North Carolina
PB - Duke University Press
AB - In June 2007 the Internal Revenue Service proposed a major overhaul of its reporting requirements for tax-exempt hospitals and released draft Form 990 (the IRS form filed by tax-exempt organizations each year). In December 2007 the IRS promulgated the final Form 990 after incorporating some of the recommendations made in the almost seven hundred public comments on the discussion draft. One recommendation adopted in the final Form 990 is the postponement until tax year 2009 (returns filed in 2010) of the requirement for hospitals to submit detailed information on the percentage of total expenses attributable to charity care, unreimbursed Medicaid costs, and community-health improvement programs (the discussion draft required this information for tax year 2007). Although the IRS will not require tax-exempt hospitals to provide detailed information about community benefits until the 2009 tax year, sixteen states have laws requiring tax-exempt hospitals to enumerate the benefits that they provide to the community. Information about the impact of these laws on the provision of community benefits (e.g., charity and uncompensated care) is examined in this study whose primary purpose is to highlight information policy makers may glean from states that have adopted community-benefit reporting laws.
SN - 0361-6878
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 19234293.
DO - 10.1215/03616878-2008-991
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chang, Qingshan
AU - Zhang, Yadong
AU - Beezhold, Kevin J.
AU - Bhatia, Deepak
AU - Zhao, Hongwen
AU - Chen, Jianguo
AU - Castranova, Vince
AU - Shi, Xianglin
AU - Chen, Fei
T1 - Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009/02//
VL - 50
IS - 2
M3 - Article
SP - 323
EP - 333
SN - 01688278
AB - Background/Aims: Aberrant c-Jun N-terminal kinase (JNK) activation has been linked to hepatocellular carcinoma (HCC) in mouse models. It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC. Methods: The JNK activation, global gene expression, and the status of histone H3 methylations were measured in 31 primary human hepatocellular carcinoma (HCC) samples paired with the adjacent non-cancerous (ANC) tissues. Results: Enhanced JNK1 activation was noted in 17 out of 31 HCC samples (55%) relative to the corresponding ANC tissues, whereas JNK2 activation was roughly equal between HCC and ANC tissues. This enhancement in JNK1 activation is associated with an increased tumor size and a lack of encapsulation of the tumors. In addition, an association of JNK1 activation with the histone H3 lysines 4 and 9 tri-methylation was observed in the HCC tissues, which leads to an elevated expression of genes regulating cell growth and a decreased expression of the genes for cell differentiation and the p450 family members in HCC. Conclusions: These results, thus, suggest that JNK1 plays important roles in the development of human HCC partially through the epigenetic mechanisms. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hepatology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENZYME activation
KW - LIVER -- Cancer
KW - JNK mitogen-activated protein kinases
KW - HISTONES
KW - METHYLATION
KW - GENE expression
KW - MICE as laboratory animals
KW - GENETIC aspects
KW - C-Jun N-terminal kinase ( JNK )
KW - cell division cycle protein 2 ( CDC2 )
KW - cyclin A2 ( CCNA )
KW - cyclin B1 ( CCNB1 )
KW - EZH2
KW - H3K4me3
KW - HCC
KW - hepatocellular carcinoma ( HCC )
KW - histone H3 lysine 4 tri-methylation ( H3K4me3 )
KW - JNK
KW - Tumor suppressor
N1 - Accession Number: 36102753; Chang, Qingshan 1 Zhang, Yadong 2 Beezhold, Kevin J. 2,3 Bhatia, Deepak 2 Zhao, Hongwen 2,4 Chen, Jianguo 5 Castranova, Vince 2 Shi, Xianglin 1,2 Chen, Fei 1,2,3; Email Address: LFD3@cdc.gov; Affiliation: 1: Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA 2: The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA 3: Cancer Cell Biology Program, West Virginia University, Morgantown, WV 26506, USA 4: Institute of Respiratory Diseases, First Affiliated Hospital, China Medical University, Shenyang 110001, PR China 5: Qidong Liver Cancer Institute, Jiangsu Province, Qidong 226200, PR China; Source Info: Feb2009, Vol. 50 Issue 2, p323; Subject Term: ENZYME activation; Subject Term: LIVER -- Cancer; Subject Term: JNK mitogen-activated protein kinases; Subject Term: HISTONES; Subject Term: METHYLATION; Subject Term: GENE expression; Subject Term: MICE as laboratory animals; Subject Term: GENETIC aspects; Author-Supplied Keyword: C-Jun N-terminal kinase ( JNK ); Author-Supplied Keyword: cell division cycle protein 2 ( CDC2 ); Author-Supplied Keyword: cyclin A2 ( CCNA ); Author-Supplied Keyword: cyclin B1 ( CCNB1 ); Author-Supplied Keyword: EZH2; Author-Supplied Keyword: H3K4me3; Author-Supplied Keyword: HCC; Author-Supplied Keyword: hepatocellular carcinoma ( HCC ); Author-Supplied Keyword: histone H3 lysine 4 tri-methylation ( H3K4me3 ); Author-Supplied Keyword: JNK; Author-Supplied Keyword: Tumor suppressor; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jhep.2008.07.037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bossarte, Robert M.
AU - Swahn, Monica H.
AU - Breiding, Matt
T1 - Racial, Ethnic, and Sex Differences in the Associations Between Violence and Self-Reported Health Among US High School Students.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2009/02//
VL - 79
IS - 2
M3 - Article
SP - 74
EP - 81
PB - Wiley-Blackwell
SN - 00224391
AB - BACKGROUND: Involvement in interpersonal violence or suicidal behaviors can have a significant impact on an adolescent’s physical health. Similarly, previous research has suggested that lived experiences, more than the presence or absence of physical ailments, can significantly influence self-assessed health status among adolescents. The purpose of this study was to examine the cross-sectional associations between involvement in violence and poor or fair self-reported health among US high school students. METHODS: Data were obtained from the 2005 national Youth Risk Behavior Survey (n = 13,953). Logistic regression analyses were conducted to determine the associations between violence-related measures and self-reported health while controlling for demographic characteristics and potential confounders. Analyses are presented for students overall and stratified by sex and race/ethnicity. RESULTS: Overall, 7.2% of students reported fair or poor self-rated health. Having been in a physical fight, having been injured in a physical fight, having attempted suicide, and having not gone to school because of safety concerns were significantly associated with fair or poor self-rated health after controlling for demographic characteristics and other potential confounders. Differences associated with race/ethnicity and sex are identified. CONCLUSIONS: Four of the 5 violence-related measures included in these analyses were significantly associated with fair or poor self-rated health. Future studies should consider the impact of involvement in violent behaviors and perceptions of both physical and mental well-being. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of School Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIOLENCE research
KW - SUICIDAL behavior
KW - RESEARCH
KW - TEENAGERS -- Health
KW - RACIAL differences
KW - GENDER differences (Psychology)
KW - UNITED States
KW - mental health
KW - mental health.
KW - public health
KW - research
KW - risk behaviors
KW - violence
N1 - Accession Number: 36324110; Bossarte, Robert M. 1; Email Address: robert_bossarte@urmc.rochester.edu Swahn, Monica H. 2; Email Address: mswahn@gsu.edu Breiding, Matt 3; Email Address: mbreiding@cdc.gov; Affiliation: 1: Assistant Professor, Department of Psychiatry, University of Rochester, 300 Crittenden Blvd, Box PSYCH, Rochester, NY 14262 2: Associate Professor, Institute of Public Health, Georgia State University, PO Box 3995, Atlanta, GA 30302-3995 3: LCDR, US Public Health Service, Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE — Mailstop F-64, Atlanta, GA 30341-3717; Source Info: Feb2009, Vol. 79 Issue 2, p74; Subject Term: VIOLENCE research; Subject Term: SUICIDAL behavior; Subject Term: RESEARCH; Subject Term: TEENAGERS -- Health; Subject Term: RACIAL differences; Subject Term: GENDER differences (Psychology); Subject Term: UNITED States; Author-Supplied Keyword: mental health; Author-Supplied Keyword: mental health.; Author-Supplied Keyword: public health; Author-Supplied Keyword: research; Author-Supplied Keyword: risk behaviors; Author-Supplied Keyword: violence; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 5900
L3 - 10.1111/j.1746-1561.2008.00379.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36324110&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - The dependencies of phase velocity and dispersion on volume fraction in cancellous-bone-mimicking phantoms.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2009/02//
VL - 125
IS - 2
M3 - Article
SP - 1197
EP - 1201
SN - 00014966
AB - Frequency-dependent phase velocity was measured in eight cancellous-bone-mimicking phantoms consisting of suspensions of randomly oriented nylon filaments (simulating trabeculae) in a soft-tissue-mimicking medium (simulating marrow). Trabecular thicknesses ranged from 152 to 356 μm. Volume fractions of nylon filament material ranged from 0% to 10%. Phase velocity varied approximately linearly with frequency over the range from 300 to 700 kHz. The increase in phase velocity (compared with phase velocity in a phantom containing no filaments) at 500 kHz was approximately proportional to volume fraction occupied by nylon filaments. The derivative of phase velocity with respect to frequency was negative and exhibited nonlinear, monotonically decreasing dependence on volume fraction. The dependencies of phase velocity and its derivative on volume fraction in these phantoms were similar to those reported in previous studies on (1) human cancellous bone and (2) phantoms consisting of parallel nylon wires immersed in water. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANALYSIS of bones
KW - SPEED of sound
KW - PHANTOMS (Radiology)
KW - BONE marrow
KW - NYLON
KW - DISPERSION
KW - VOLUME (Cubic content)
KW - BIOMIMICRY
N1 - Accession Number: 76460916; Wear, Keith A. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142, 12720 Twinbrook Parkway, Rockville, Maryland 20852; Source Info: Feb2009, Vol. 125 Issue 2, p1197; Subject Term: ANALYSIS of bones; Subject Term: SPEED of sound; Subject Term: PHANTOMS (Radiology); Subject Term: BONE marrow; Subject Term: NYLON; Subject Term: DISPERSION; Subject Term: VOLUME (Cubic content); Subject Term: BIOMIMICRY; NAICS/Industry Codes: 313110 Fiber, Yarn, and Thread Mills; Number of Pages: 5p; Document Type: Article
L3 - 10.1121/1.3050310
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shuang Tang
AU - Patel, Amita
AU - Krause, Philip R.
T1 - Novel Less-Abundant Viral MicroRNAs Encoded by Herpes Simplex Virus 2 Latency-Associated Transcript and Their Roles in Regulating ICP34.5 and ICP0 mRNAs.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/02//
VL - 83
IS - 3
M3 - Article
SP - 1433
EP - 1442
SN - 0022538X
AB - We recently identified an acutely and latently expressed viral microRNA (miRNA), miR-I, encoded by herpes simplex virus 2 (HSV-2) latency-associated transcript (LAT) through small RNA cloning and two miRNAs encoded by HSV-1 LAT through prediction. We now report the use of high-throughput sequencing technology to identify two additional relatively less-abundant viral miRNAs, miR-II and miR-III, encoded by HSV-2 LAT exon 2. miR-II includes two miRNAs, miR-II-5p and miR-II-3p, which are processed from the same miRNA precursor. miR-II and miR-III map antisense to the 5' untranslated region of ICP34.5 and to the coding region of ICP0 exon 3, respectively. These novel miRNAs are conserved in different HSV-2 strains, and their presence in infected- and transfected-cell cultures was confirmed by Northern hybridization. All three HSV-2 LAT-encoded miRNAs map to genome locations similar to those of three out of four identified HSV-1 LAT-encoded miRNAs, but the sequences of these miRNAs are not conserved. The expression of LAT-encoded miRNAs is negatively regulated by ICP4, the major viral transactivator. We further show that, similar to miR-I, miR-II is able to efficiently silence the expression of ICP34.5, a key viral neurovirulence factor, and that miR-III is able to silence the expression of ICP0, a key viral transactivator. All these data suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their viral targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - HERPES simplex virus
KW - HERPESVIRUSES
KW - GENETIC transcription
KW - MESSENGER RNA
KW - GENETIC engineering
N1 - Accession Number: 36422097; Shuang Tang 1 Patel, Amita 1 Krause, Philip R. 1; Email Address: Philip.krause@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Feb2009, Vol. 83 Issue 3, p1433; Subject Term: RNA; Subject Term: HERPES simplex virus; Subject Term: HERPESVIRUSES; Subject Term: GENETIC transcription; Subject Term: MESSENGER RNA; Subject Term: GENETIC engineering; Number of Pages: 10p; Document Type: Article
L3 - 10.1128/JVI.01723-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lê Cook, Benjamin
AU - McGuire, Thomas G.
AU - Zuvekas, Samuel H.
T1 - Measuring Trends in Racial/Ethnic Health Care Disparities.
JO - Medical Care Research & Review
JF - Medical Care Research & Review
Y1 - 2009/02//
VL - 66
IS - 1
M3 - Article
SP - 23
EP - 48
SN - 10775587
AB - Monitoring disparities over time is complicated by the varying disparity definitions applied in the literature. This study used data from the 1996-2005 Medical Expenditure Panel Survey (MEPS) to compare trends in disparities by three definitions of racial/ethnic disparities and to assess the influence of changes in socioeconomic status (SES) among racial/ethnic minorities on disparity trends. This study prefers the Institute of Medicine's (IOM) definition, which adjusts for health status but allows for mediation of racial/ethnic disparities through SES factors. Black—White disparities in having an office-based or outpatient visit and medical expenditure were roughly constant and Hispanic—White disparities increased for office-based or outpatient visits and for medical expenditure between 1996-1997 and 2004-2005. Estimates based on the independent effect of race/ethnicity were the most conservative accounting of disparities and disparity trends, underlining the importance of the role of SES mediation in the study of trends in disparities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Care Research & Review is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Research
KW - REGIONAL disparities
KW - MEDICINE -- Study & teaching
KW - SOCIAL status
KW - DIFFERENCES
KW - medical expenditure
KW - racial disparities
KW - statistical adjustment for health status
KW - trends
N1 - Accession Number: 36312461; Lê Cook, Benjamin 1 McGuire, Thomas G. 2 Zuvekas, Samuel H. 3; Affiliation: 1: Cambridge Health Alliance/Harvard Medical School, Somerville, MA 2: Harvard Medical School, Boston, MA 3: Agency for Healthcare Research and Quality, Rockville, MD; Source Info: Feb2009, Vol. 66 Issue 1, p23; Subject Term: MEDICAL care -- Research; Subject Term: REGIONAL disparities; Subject Term: MEDICINE -- Study & teaching; Subject Term: SOCIAL status; Subject Term: DIFFERENCES; Author-Supplied Keyword: medical expenditure; Author-Supplied Keyword: racial disparities; Author-Supplied Keyword: statistical adjustment for health status; Author-Supplied Keyword: trends; Number of Pages: 26p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Desai, Varsha G.
AU - Lee, Taewon
AU - Moland, Carrie L.
AU - Branham, William S.
AU - Von Tungeln, Linda S.
AU - Beland, Frederick A.
AU - Fuscoe, James C.
T1 - Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2009/02//
VL - 9
IS - 1
M3 - Article
SP - 9
EP - 16
SN - 15677249
AB - Abstract: Zidovudine (3′-azido-3′-deoxythymidine; AZT) is the main anti-retroviral drug given to HIV-1-infected pregnant women during pregnancy and to their infants after birth to reduce mother-to-child transmission of the virus. In animal studies, however, a significant mitochondrial morphological damage has been reported in skeletal muscle as a consequence of transplacental or perinatal exposure to AZT. Because proper muscle function is highly dependent on efficient mitochondrial function and information on AZT-induced mitochondrial toxicity during neonatal exposure is limited, we investigated the effect of AZT on the expression of 542 mitochondria-related genes encoded by both nuclear and mitochondrial DNA in the skeletal muscle of infant male and female mice using microarray technology. Animals were treated orally by gavage with AZT at 0, 10, 50, 100, and 200mg/kg body weight/day from postnatal day (PND) 1 through 8 and were sacrificed at 1- and 2-h following the last dose on PND 8. These doses in mice correspond to 0, 1.1, 5.5, 11.0, and 22.0mg/kg AZT in human infants [Center for Drug Evaluation and Research (CDER) 2005. Pharmacology and Toxicology, Guidance for industry. Estimating the maximum safe dose in initial clinical trials for therapeutics in adult healthy volunteers, p. 7. http://www.fda.gov/cder/guidance/index.htm.]. Microarray data were analyzed for effects of time, sex, treatment, and their interactions using a fixed effect linear model. The results showed modest, but significant, dose-related responses in the expression level of genes associated with apoptosis, fatty acid metabolism, mitochondrial DNA maintenance, and various mitochondrial membrane transporters. The transcription levels were not significantly different at both time points and were not sex dependent. The results suggest that changes in expression of mitochondria-related genes in skeletal muscle may be an initial response to short-term AZT exposure in infant mice. [Copyright &y& Elsevier]
AB - Copyright of Mitochondrion is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AZT (Drug)
KW - MITOCHONDRIA
KW - GENE expression
KW - MICE
KW - ANATOMY
KW - MITOCHONDRIAL DNA
KW - DOSE-response relationship (Biochemistry)
KW - Infant B6C3F1 mouse
KW - Mitochondrial functions
KW - Skeletal muscle
KW - Zidovudine (AZT)
N1 - Accession Number: 36565846; Desai, Varsha G. 1; Email Address: varsha.desai@fda.hhs.gov Lee, Taewon 2 Moland, Carrie L. 1 Branham, William S. 1 Von Tungeln, Linda S. 3 Beland, Frederick A. 3 Fuscoe, James C. 1; Affiliation: 1: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Feb2009, Vol. 9 Issue 1, p9; Subject Term: AZT (Drug); Subject Term: MITOCHONDRIA; Subject Term: GENE expression; Subject Term: MICE; Subject Term: ANATOMY; Subject Term: MITOCHONDRIAL DNA; Subject Term: DOSE-response relationship (Biochemistry); Author-Supplied Keyword: Infant B6C3F1 mouse; Author-Supplied Keyword: Mitochondrial functions; Author-Supplied Keyword: Skeletal muscle; Author-Supplied Keyword: Zidovudine (AZT); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mito.2008.09.002
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Koeberl, Dwight
AU - Kishnani, Priya
AU - Goldenberg, Paula
AU - Dearmey, Stephanie
AU - Heller, James
AU - Benjamin, Danny
AU - Young, Sarah
AU - Bali, Deeksha
AU - Smith, Sue Ann
AU - Li, Jennifer
AU - Mandel, Hanna
AU - Rosenburg, Amy
AU - Chen, Y-T
T1 - 77. Cross-reacting immunologic material status affects outcomes in infants with Pompe disease treated with alglucosidase alfa
JO - Molecular Genetics & Metabolism
JF - Molecular Genetics & Metabolism
Y1 - 2009/02//
VL - 96
IS - 2
M3 - Abstract
SP - S28
EP - S29
SN - 10967192
N1 - Accession Number: 36140773; Koeberl, Dwight 1 Kishnani, Priya 1 Goldenberg, Paula 1 Dearmey, Stephanie 1 Heller, James 1 Benjamin, Danny 1 Young, Sarah 1 Bali, Deeksha 1 Smith, Sue Ann 2 Li, Jennifer 1 Mandel, Hanna 3 Rosenburg, Amy 4 Chen, Y-T 1,5; Affiliation: 1: Duke University Medical Center, Durham, NC, USA 2: Oregon Health Sciences University, Portland, OR, USA 3: Rambam Medical Center, Haifa, Israel 4: Office of Biotechnology Products, Center for Drug Evaluation and Research 5: Institute of Biomedical Sciences, Academica Sinica, Taipei, Taiwan; Source Info: Feb2009, Vol. 96 Issue 2, pS28; Number of Pages: 0p; Document Type: Abstract
L3 - 10.1016/j.ymgme.2008.11.078
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36140773&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Wen Jin Wu
AU - Hirsch, Dianne S.
T1 - Mechanism of E-cadherin lysosomal degradation.
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
Y1 - 2009/02//
VL - 9
IS - 2
M3 - Letter
SP - 143
EP - 143
PB - Nature Publishing Group
SN - 1474175X
AB - A letter to the editor is presented in response to the article "Derailed endocytosis: An Emerging Feature of Cancer," by Yaron Mosesson, Gordon B. Mills and Yosef Yarden in the 2008 issue.
KW - LETTERS to the editor
KW - ENDOCYTOSIS
N1 - Accession Number: 36195016; Wen Jin Wu 1; Email Address: wen.wu@fda.hhs.gov Hirsch, Dianne S. 1; Affiliation: 1: Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA; Source Info: Feb2009, Vol. 9 Issue 2, p143; Subject Term: LETTERS to the editor; Subject Term: ENDOCYTOSIS; Number of Pages: 1p; Document Type: Letter
L3 - 10.1038/nrc2521-c1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36195016&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kheifets, L.
AU - Bowman, J. D.
AU - Checkoway, H.
AU - Feychting, M.
AU - Harrington, J. M.
AU - Kavet, R.
AU - Marsh, G.
AU - Mezei, G.
AU - Renew, D. C.
AU - van Wijngaarden, E.
T1 - Future needs of occupational epidemiology of extremely low frequency electric and magnetic fields: review and recommendations.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2009/02//
VL - 66
IS - 2
M3 - Article
SP - 72
EP - 80
SN - 13510711
AB - The occupational epidemiological literature on extremely low frequency electric and magnetic fields (EMF) and health encompasses a large number of studies of varying design and quality that have addressed many health outcomes, including various cancers, cardiovascular disease, depression and suicide, and neurodegenerative diseases, such as Alzheimer disease and amyotrophic lateral sclerosis (ALS). At a 2006 workshop we reviewed studies of occupational EMF exposure with an emphasis on methodological weaknesses, and proposed analytical ways to address some of these. We also developed research priorities that we hope will address remaining uncertainties. Broadly speaking, extensive epidemiological research conducted during the past 20 years on occupational EMF exposure does not indicate strong or consistent associations with cancer or any other health outcomes. Inconsistent results for many of the outcomes may be attributable to numerous shortcomings in the studies, most notably in exposure assessment. There is, however, no obvious correlation between exposure assessment quality and observed associations. Nevertheless, for future research, the highest priorities emerge in both the areas of exposure assessment and investigation of ALS. To better assess exposure, we call for the development of a more complete job-exposure matrix that combines job title, work environment and task, and an index of exposure to electric fields, magnetic fields, spark discharge, contact current, and other chemical and physical agents. For ALS, we propose an international collaborative study capable of illuminating a reported association with electrical occupations by disentangling the potential roles of electric shocks, magnetic fields and bias. Such a study will potentially lead to evidence-based measures to protect public health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Magnetic fields
KW - Epidemiology
KW - Health
KW - Field theory (Physics)
KW - Social epidemiology
KW - Ecosocial theory (Social medicine)
KW - Cardiovascular diseases
KW - Anxiety
KW - Neurodegeneration
N1 - Accession Number: 36825914; Kheifets, L. 1; Email Address: kheifets@ucla.edu; Bowman, J. D. 2; Checkoway, H. 3; Feychting, M. 4; Harrington, J. M. 5; Kavet, R. 6; Marsh, G. 7; Mezei, G. 6; Renew, D. C. 8; van Wijngaarden, E. 9; Affiliations: 1: Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA; 2: National Institute for Occupational Safety and Health, Engineering and Physical Hazards Branch, Cincinnati, Ohio, USA; 3: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA; 4: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 5: Institute of Occupational Health, University of Birmingham, Birmingham, UK; 6: Electric Power Research Institute, Palo Alto, California, USA; 7: Department of Biostatistics, Oraduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; 8: National Grid plc, London, UK; 9: Division of Epidemiology, Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; Issue Info: Feb2009, Vol. 66 Issue 2, p72; Thesaurus Term: Magnetic fields; Thesaurus Term: Epidemiology; Thesaurus Term: Health; Subject Term: Field theory (Physics); Subject Term: Social epidemiology; Subject Term: Ecosocial theory (Social medicine); Subject Term: Cardiovascular diseases; Subject Term: Anxiety; Subject Term: Neurodegeneration; Number of Pages: 9p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1136/oem.2007.037994
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105470516
T1 - Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors.
AU - Cohen MH
AU - Farrell A
AU - Justice R
AU - Pazdur R
Y1 - 2009/02//
N1 - Accession Number: 105470516. Language: English. Entry Date: 20090424. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Gastrointestinal Neoplasms -- Drug Therapy
KW - Imatinib -- Therapeutic Use
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Imatinib -- Administration and Dosage
KW - Imatinib -- Adverse Effects
KW - Treatment Outcomes
SP - 174
EP - 180
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 14
IS - 2
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - The purpose of the present application was to fulfill a postmarketing commitment to provide long-term efficacy and safety data on treatment with imatinib mesylate (Gleevec; Novartis Pharmaceuticals, East Hanover, NJ) in patients with CD117(+) unresectable and/or metastatic malignant gastrointestinal stromal tumors (GISTs). In addition, this application also provides evidence to support a change in the label to allow for an escalation of imatinib dosing to 800 mg/day for patients with progressive disease on a lower dose. Two open-label, controlled, multicenter, intergroup, international, randomized phase III studies were submitted -- one conducted by the European Organization for Research and Treatment of Cancer (n = 946) and the other by the Southwest Oncology Group (n = 746). These studies compared 400 mg/day of imatinib with 800 mg/day of imatinib. A combined analysis of the two studies was prospectively defined and agreed to by both groups. Both protocols allowed patients randomized to the 400-mg/day imatinib arm to cross over to 800 mg/day imatinib at progression. Objective responses were achieved in >50% of patients receiving either imatinib dose. The median progression-free survival time was approximately 20 months and the median overall survival (OS) time was approximately 49 months. In the combined analysis, 347 patients crossed over to 800 mg/day imatinib at the time of progression. The median OS time after crossover was 14.3 months. The most common adverse events (AEs) were fluid retention, nausea, fatigue, skin rash, gastrointestinal complaints, and myalgia. The most common laboratory abnormality was anemia. Most often the AEs were of mild-to-moderate severity. Fluid retention events and skin rash were numerically reported more often in the 800-mg/day treatment cohort of patients.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA. martin.cohen@fda.hhs.gov
U2 - PMID: 19193781.
DO - 10.1634/theoncologist.2008-0255
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jin-Hee Hwang
AU - Wook-Gyo Lee
AU - Byoung-Kuk Na
AU - Hyeong-Woo Lee
AU - Shin-Hyeong Cho
AU - Tong-Soo Kim
T1 - Identification and characterization of a serine protease inhibitor of Paragonimus westermani.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2009/02//
VL - 104
IS - 3
M3 - Article
SP - 495
EP - 501
SN - 09320113
AB - Abstract Paragonimus westermani is a trematode parasite that causes pulmonary and/or extrapulmonary granulomatous disease in humans. In this study, we identified a full-length gene encoding a novel serine protease inhibitor of P. westermani (PwSERPIN) and characterized the biochemical properties of the recombinant protein. PwSERPIN had an open reading frame of 1,164 bp, which encoded 387 amino acid residues. Sequence analysis of the primary structure of PwSERPIN revealed that it had the essential structural motifs which were well conserved among the serine protease inhibitor (serpin) superfamily and had shown 16.5–29.6% sequence identities with previously reported serpins from other helminthic parasites. No signal peptide or N-glycosylation site was found in the sequence. Genomic DNA structure analysis showed that PwSERPIN comprised six exons separated by five introns. The bacterially expressed recombinant PwSERPIN effectively inhibited the activities of trypsin, thrombin, and chymotrypsin in a dose-dependent manner, but showed lower inhibitory capacity on cathepsin G and elastases. Expression of PwSERPIN was detected throughout various developmental stages of the parasite, from metacercariae to adult worms, and the transcription level gradually increased with the maturation of the parasite. PwSERPIN was identified in the soluble extract of the parasite, but not in the excretory and secretory products (ESP) and in the insoluble extract of the parasite. These results collectively suggest that the PwSERPIN is an intracellular serpin of P. westermani and that might play primary roles in regulating the activities of intracellular serine proteases of the parasite. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HELMINTHS
KW - SERINE proteinases -- Inhibitors
KW - CELLULAR control mechanisms
KW - GRANULOMA
KW - GENETIC code
KW - BIOCHEMISTRY
KW - RECOMBINANT proteins
KW - BACTERIAL proteins
N1 - Accession Number: 36232035; Jin-Hee Hwang 1 Wook-Gyo Lee 2 Byoung-Kuk Na 3 Hyeong-Woo Lee 2 Shin-Hyeong Cho 2 Tong-Soo Kim 4; Affiliation: 1: Korea Food and Drug Administration Seoul 122-701 South Korea 2: National Institute of Health, Korea Centers for Disease Control and Prevention Division of Malaria and Parasitic Diseases Seoul 122-701 South Korea 3: Gyeongsang National University College of Medicine Department of Parasitology and Institute of Health Sciences Jinju 660-751 South Korea 4: Inha University College of Medicine Department of Parasitology and Inha Research Institute for Medical Sciences Incheon 400-712 South Korea; Source Info: Feb2009, Vol. 104 Issue 3, p495; Subject Term: HELMINTHS; Subject Term: SERINE proteinases -- Inhibitors; Subject Term: CELLULAR control mechanisms; Subject Term: GRANULOMA; Subject Term: GENETIC code; Subject Term: BIOCHEMISTRY; Subject Term: RECOMBINANT proteins; Subject Term: BACTERIAL proteins; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105448368
T1 - Hallucinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children.
AU - Mosholder AD
AU - Gelperin K
AU - Hammad TA
AU - Phelan K
AU - Johann-Liang R
Y1 - 2009/02//
N1 - Accession Number: 105448368. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Adverse Drug Event
KW - Attention Deficit Hyperactivity Disorder -- Drug Therapy
KW - Hallucinations
KW - Psychotropic Drugs -- Adverse Effects
KW - Amphetamines -- Adverse Effects
KW - Atomoxetine -- Adverse Effects
KW - Confidence Intervals
KW - Cyclothymic Disorder
KW - Data Analysis Software
KW - Product Surveillance
KW - Psychotic Disorders -- Symptoms
KW - Treatment Outcomes
KW - Human
SP - 611
EP - 616
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 123
IS - 2
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVES: To gain a better understanding of the capacity of psychostimulant medications to induce adverse psychiatric reactions and determine the frequency of such reactions, we analyzed postmarketing surveillance data and clinical trial data for drugs, either approved or under development, for the treatment of attention-deficit/hyperactivity disorder. METHODS: The US Food and Drug Administration requested manufacturers of drugs approved for attention-deficit/hyperactivity disorder or with active clinical development programs for that indication to search their electronic clinical trial databases for cases of psychosis or mania using prespecified search terms. The manufacturers supplied descriptions of clinical trials, numbers of patients exposed to study drug, and duration of exposure to permit calculations of incidence rates. Independently, cases of psychosis or mania in children and adults for drugs used to treat attention-deficit/hyperactivity disorder from the Food and Drug Administration Adverse Event Reporting System safety database were analyzed. Manufacturers were asked to conduct similar analyses of their postmarketing surveillance databases. RESULTS: We analyzed data from 49 randomized, controlled clinical trials in the pediatric development programs for these products. A total of 11 psychosis/mania adverse events occurred during 743 person-years of double-blind treatment with these drugs, and no comparable adverse events occurred in a total of 420 person-years of placebo exposure in the same trials. The rate per 100 person-years in the pooled active drug group was 1.48. The analysis of spontaneous postmarketing reports yielded >800 reports of adverse events related to psychosis or mania. In approximately 90% of the cases, there was no reported history of a similar psychiatric condition. Hallucinations involving visual and/or tactile sensations of insects, snakes, or worms were common in cases in children. CONCLUSIONS: Patients and physicians should be aware that psychosis or mania arising during drug treatment of attention-deficit/hyperactivity disorder may represent adverse drug reactions.
SN - 0031-4005
AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA.
U2 - PMID: 19171629.
DO - 10.1542/peds.2008-0185
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ye, Xiaofei
AU - Fu, Zheng
AU - Wang, Hainan
AU - Du, Wenmin
AU - Wang, Rui
AU - Sun, Yalin
AU - Gao, Qingbin
AU - He, Jia
T1 - A computerized system for signal detection in spontaneous reporting system of Shanghai China.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/02//
VL - 18
IS - 2
M3 - Article
SP - 154
EP - 158
SN - 10538569
AB - Purpose We developed a computerized system for signal detection in spontaneous reporting system (SRS) of Shanghai. Data acquisition, data mining could be carried out automatically and the process of data preprocessing and cleaning could be facilitated. This system was expected to detect signals from SRS after drug licensing with minimum patient exposure. Methods This system was developed by Microsoft visual basic (VB) 6.0. Data preprocessing, data cleaning, and data mining were based upon visual basic for application (VBA) in Microsoft Excel 2003. Database of drug generic name and adverse drug reaction (ADR) standard dictionary were set up initially for data cleaning and coding. Algorithms including reporting odds ratio (ROR), proportional reporting ratio (PRR), measure used by the Medicines and Healthcare Products Regulatory Agency (MHRA), Bayesian confidence propagation neural network (BCPNN) were employed in this system. Crude ADR reports submitted to Shanghai ADR SRS from December 2003 to April 2007 were used as a material in this study to test the feasibility and flexibility of this system. Results Thirty two thousand seven hundred and fourty six crude ADR reports were acquired from the SRS automatically. Two thousand one hundred and fourty seven drug generic name and 621 ADR name were kept in the database after data preprocessing and cleaning. A total of 1430, 1419, 868 and 997 possible drug-ADR signals were generated by ROR, PRR, BCPNN and MHRA, respectively. Conclusions The results indicate that this computerized system is a flexible one that can help to detect possible drug-ADR signals intelligently in SRS of Shanghai now. It is a promising system for post-marketing surveillance on both chemical medicine and Chinese traditional medicine. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707256; Ye, Xiaofei 1; Fu, Zheng 1; Wang, Hainan 1,2; Du, Wenmin 3; Wang, Rui 1; Sun, Yalin 1; Gao, Qingbin 1; He, Jia 1; Affiliations: 1: Department of Health Statistics, Second Military Medical University, Shanghai, China; 2: Center for Drug Evaluation, State Food and Drug Administration, Beijing, China; 3: Adverse Drug Reaction Monitoring Center of Shanghai, Shanghai, China; Issue Info: Feb2009, Vol. 18 Issue 2, p154; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.1695
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shvedova, A.A.
AU - Kisin, E.R.
AU - Porter, D.
AU - Schulte, P.
AU - Kagan, V.E.
AU - Fadeel, B.
AU - Castranova, V.
T1 - Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
JO - Pharmacology & Therapeutics
JF - Pharmacology & Therapeutics
Y1 - 2009/02//
VL - 121
IS - 2
M3 - Article
SP - 192
EP - 204
SN - 01637258
AB - Abstract: Nanotechnology is an emerging science involving manipulation of materials at the nanometer scale. There are several exciting prospects for the application of engineered nanomaterials in medicine. However, concerns over adverse and unanticipated effects on human health have also been raised. In fact, the same properties that make engineered nanomaterials attractive from a technological and biomedical perspective could also make these novel materials harmful to human health and the environment. Carbon nanotubes are cylinders of one or several coaxial graphite layer(s) with a diameter in the order of nanometers, and serve as an instructive example of the Janus-like properties of nanomaterials. Numerous in vitro and in vivo studies have shown that carbon nanotubes and/or associated contaminants or catalytic materials that arise during the production process may induce oxidative stress and prominent pulmonary inflammation. Recent studies also suggest some similarities between the pathogenic properties of multi-walled carbon nanotubes and those of asbestos fibers. On the other hand, carbon nanotubes can be readily functionalized and several studies on the use of carbon nanotubes as versatile excipients for drug delivery and imaging of disease processes have been reported, suggesting that carbon nanotubes may have a place in the armamentarium for treatment and monitoring of cancer, infection, and other disease conditions. Nanomedicine is an emerging field that holds great promise; however, close attention to safety issues is required to ensure that the opportunities that carbon nanotubes and other engineered nanoparticles offer can be translated into feasible and safe constructs for the treatment of human disease. [Copyright &y& Elsevier]
AB - Copyright of Pharmacology & Therapeutics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FULLERENES
KW - NANOTUBES
KW - ENVIRONMENTAL protection
KW - SUPEROXIDE dismutase
KW - 5-dimethylthiazol-2-yl)-2
KW - 5-diphenyltetrazolium bromide] ( MTT )
KW - Biomedical applications
KW - Carbon nanotubes
KW - carbon nanotubes ( CNT )
KW - Cellular interactions
KW - cobalt–molybdenum catalyst process ( CoMoCAT )
KW - diethylenetriaminepentaacetic ( DTPA )
KW - dispersed single-walled carbon nanotubes ( DSWCNT )
KW - Environmental Protection Agency ( EPA )
KW - high aspect ratio nanoparticles ( HARN )
KW - high-pressure carbon monoxide process ( HiPco )
KW - intratracheal ( IT )
KW - listeria monocytogenes ( LM )
KW - micronucleus ( MN )
KW - multi-walled carbon nanotubes ( MWCNT )
KW - Nanotoxicology
KW - nicotinamide adenine dinucleotide phosphate ( NADPH )
KW - Occupational Safety and Health Administration ( OSHA )
KW - permissible exposure level ( PEL )
KW - phosphatidylserine ( PS )
KW - polymorphonuclear neutrophils ( PMNs )
KW - Pulmonary toxicity
KW - reactive oxygen species ( ROS )
KW - single-walled carbon nanotubes ( SWCNT )
KW - superoxide dismutase ( SOD )
KW - Toxic Substances Control Act ( TSCA )
KW - [3-(4
KW - [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] ( MTT )
N1 - Accession Number: 36563639; Shvedova, A.A. 1,2; Email Address: ats1@cdc.gov Kisin, E.R. 1 Porter, D. 1,2 Schulte, P. 3 Kagan, V.E. 4 Fadeel, B. 5 Castranova, V. 1; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States 2: Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, United States 3: Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, OH, United States 4: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, United States 5: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Source Info: Feb2009, Vol. 121 Issue 2, p192; Subject Term: FULLERENES; Subject Term: NANOTUBES; Subject Term: ENVIRONMENTAL protection; Subject Term: SUPEROXIDE dismutase; Author-Supplied Keyword: 5-dimethylthiazol-2-yl)-2; Author-Supplied Keyword: 5-diphenyltetrazolium bromide] ( MTT ); Author-Supplied Keyword: Biomedical applications; Author-Supplied Keyword: Carbon nanotubes; Author-Supplied Keyword: carbon nanotubes ( CNT ); Author-Supplied Keyword: Cellular interactions; Author-Supplied Keyword: cobalt–molybdenum catalyst process ( CoMoCAT ); Author-Supplied Keyword: diethylenetriaminepentaacetic ( DTPA ); Author-Supplied Keyword: dispersed single-walled carbon nanotubes ( DSWCNT ); Author-Supplied Keyword: Environmental Protection Agency ( EPA ); Author-Supplied Keyword: high aspect ratio nanoparticles ( HARN ); Author-Supplied Keyword: high-pressure carbon monoxide process ( HiPco ); Author-Supplied Keyword: intratracheal ( IT ); Author-Supplied Keyword: listeria monocytogenes ( LM ); Author-Supplied Keyword: micronucleus ( MN ); Author-Supplied Keyword: multi-walled carbon nanotubes ( MWCNT ); Author-Supplied Keyword: Nanotoxicology; Author-Supplied Keyword: nicotinamide adenine dinucleotide phosphate ( NADPH ); Author-Supplied Keyword: Occupational Safety and Health Administration ( OSHA ); Author-Supplied Keyword: permissible exposure level ( PEL ); Author-Supplied Keyword: phosphatidylserine ( PS ); Author-Supplied Keyword: polymorphonuclear neutrophils ( PMNs ); Author-Supplied Keyword: Pulmonary toxicity; Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: single-walled carbon nanotubes ( SWCNT ); Author-Supplied Keyword: superoxide dismutase ( SOD ); Author-Supplied Keyword: Toxic Substances Control Act ( TSCA ); Author-Supplied Keyword: [3-(4; Author-Supplied Keyword: [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] ( MTT ); Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.pharmthera.2008.10.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kannan, Meganathan
AU - Ahmad, Firdos
AU - Yadav, Birendra Kumar
AU - Anand, Mona
AU - Jain, Paresh
AU - Kumar, Rajive
AU - Saxena, Renu
T1 - Glanzmann's thrombasthenia in North Indians: Sub classification and carrier detection by flow cytometry.
JO - Platelets
JF - Platelets
Y1 - 2009/02//
VL - 20
IS - 1
M3 - Article
SP - 12
EP - 15
PB - Taylor & Francis Ltd
SN - 09537104
AB - Thirty-three patients of Glanzmann's thrombasthenia (GT) and their families were assessed for the expression of αIIbβ3 on platelet surface, by flow cytometry, to determine the common subtypes in North Indians as well as to assess the carrier status in family members of GT patients. GT was diagnosed in patients with bleeding manifestations accompanied by absent/reduced platelet aggregation, secondary to adenosine-di-phosphate, adrenaline, arachidonic acid and collagen. Based on αIIbβ3 levels, 21 patients (64%) were classified as type I (as αIIbβ3 was absent), 4 patients (12%) as type II and 8 patients (24%) as type III. Eight out of 20 fathers, 10 out of 20 mothers and 20 out of 31 siblings were found to have reduced αIIbβ3 levels. Reduced αIIbβ3 expression was seen in 63% of parents and 65% of siblings. It is possible that low αIIbβ3 levels in family members may reflect their carrier status. It is postulated that flow cytometry estimation of αIIbβ3 in parents/siblings may detect carrier status in GT. It is also revealed that type I GT is the commonest subtype in North Indians. [ABSTRACT FROM AUTHOR]
AB - Copyright of Platelets is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOMETRY
KW - BLOOD platelets
KW - EXTRACELLULAR matrix proteins
KW - ARACHIDONIC acid
KW - COLLAGEN
KW - INDIGENOUS peoples of the Americas
KW - carrier detection
KW - flow cytometry
KW - Glanzmann's Thrombasthenia
KW - North India
N1 - Accession Number: 36244062; Kannan, Meganathan 1,2 Ahmad, Firdos 1 Yadav, Birendra Kumar 1 Anand, Mona 3 Jain, Paresh 3 Kumar, Rajive 3 Saxena, Renu 1; Email Address: renusax@hotmail.com; Affiliation: 1: Department of Haematology, All India Institute of Medical Sciences, New Delhi, India 2: Division of Hematology, CBER, U.S. Food and Drug Administration, Bethesda, MD, USA 3: Laboratory Oncology Unit, IRCH, All India Institute of Medical Sciences, New Delhi, India; Source Info: Feb2009, Vol. 20 Issue 1, p12; Subject Term: CYTOMETRY; Subject Term: BLOOD platelets; Subject Term: EXTRACELLULAR matrix proteins; Subject Term: ARACHIDONIC acid; Subject Term: COLLAGEN; Subject Term: INDIGENOUS peoples of the Americas; Author-Supplied Keyword: carrier detection; Author-Supplied Keyword: flow cytometry; Author-Supplied Keyword: Glanzmann's Thrombasthenia; Author-Supplied Keyword: North India; Number of Pages: 4p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/09537100802434853
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Konduru, Nagarjun V.
AU - Tyurina, Yulia Y.
AU - Weihong Feng
AU - Basova, Liana V.
AU - Belikova, Natalia A.
AU - Bayir, Hülya
AU - Katherine Clark
AU - Marc Rubin
AU - Donna Stolz
AU - Helen Vallhov
AU - Annika Scheynius
AU - Erika Witasp
AU - Bengt Fadeel
AU - Padmakar D. Kichambare
AU - Alexander Star
AU - Elena R. Kisin
AU - Murray, Ashley R.
AU - Shvedova, Anna A.
AU - Valerian E. Kagan
T1 - Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/02//
VL - 4
IS - 2
M3 - Article
SP - 1
EP - 17
PB - Public Library of Science
SN - 19326203
AB - Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We report that SWCNT coating with a phospholipid ''eat-me'' signal, phosphatidylserine (PS), makes them recognizable in vitro by different phagocytic cells - murine RAW264.7 macrophages, primary monocyte-derived human macrophages, dendritic cells, and rat brain microglia. Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion. Loading of PS-coated SWCNT with pro-apoptotic cargo (cytochrome c) allowed for the targeted killing of RAW264.7 macrophages. In vivo aspiration of PS-coated SWCNT stimulated their uptake by lung alveolar macrophages in mice. Thus, PS-coating can be utilized for targeted delivery of SWCNT with specified cargoes into professional phagocytes, hence for therapeutic regulation of specific populations of immune-competent cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHATIDYLSERINES
KW - CARBON nanotubes
KW - PHAGOCYTES
KW - MACROPHAGES
KW - DENDRITIC cells
KW - MICROGLIA
KW - CARRIER proteins
N1 - Accession Number: 55666448; Konduru, Nagarjun V. 1 Tyurina, Yulia Y. 1 Weihong Feng 1 Basova, Liana V. 1 Belikova, Natalia A. 1 Bayir, Hülya 1 Katherine Clark 2 Marc Rubin 2 Donna Stolz 2 Helen Vallhov 3 Annika Scheynius 3 Erika Witasp 4 Bengt Fadeel 4 Padmakar D. Kichambare 5 Alexander Star 5 Elena R. Kisin 6 Murray, Ashley R. 6 Shvedova, Anna A. 6 Valerian E. Kagan 1,4; Email Address: kagan@pitt.edu; Affiliation: 1: Center for Free Radical and Antioxidant Health, Graduate School of Public Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America 2: Department of Cell Biology & Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America 3: Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden 4: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 5: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America 6: Pathology/Physiology Research Branch, Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, United States of America; Source Info: 2009, Vol. 4 Issue 2, p1; Subject Term: PHOSPHATIDYLSERINES; Subject Term: CARBON nanotubes; Subject Term: PHAGOCYTES; Subject Term: MACROPHAGES; Subject Term: DENDRITIC cells; Subject Term: MICROGLIA; Subject Term: CARRIER proteins; Number of Pages: 17p; Illustrations: 8 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0004398
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105469969
T1 - Initial evaluation of the Peer-to-Peer program.
AU - Lucksted A
AU - McNulty K
AU - Brayboy L
AU - Forbes C
AU - Lucksted, Alicia
AU - McNulty, Kathryn
AU - Brayboy, Lorener
AU - Forbes, Courtney
Y1 - 2009/02//
N1 - Accession Number: 105469969. Language: English. Entry Date: 20090417. Revision Date: 20170307. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. Grant Information: Funded by NAMI's national office, and in part by AstraZeneca. NLM UID: 9502838.
KW - Mental Disorders -- Rehabilitation
KW - Mentorship
KW - Peer Group
KW - Self Care
KW - Adult
KW - Age Factors
KW - Chi Square Test
KW - Confidence Intervals
KW - Fisher's Exact Test
KW - Funding Source
KW - National Alliance for the Mentally Ill
KW - Odds Ratio
KW - P-Value
KW - Pilot Studies
KW - Pretest-Posttest Design
KW - Program Evaluation
KW - Qualitative Studies
KW - Surveys
KW - Wilcoxon Signed Rank Test
KW - Human
SP - 250
EP - 253
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 60
IS - 2
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - Objective: Peer-to-Peer, sponsored by the National Alliance on Mental Illness (NAMI), is a structured, experiential, self-empowerment, relapse prevention and wellness program led by trained peer mentors for people with mental illnesses. The authors conducted the first empirical evaluation of the program by using a pre-post survey design.Methods: Approximately 550 participants who were enrolled in Peer-to-Peer during the data collection period (2005-2006) were invited to complete a brief, anonymous survey before participating in the program and immediately after.Results: Analyses of responses from 138 participants indicated that they gained significant benefits, especially in areas central to the Peer-to-Peer curriculum--specifically, knowledge and management of their illness, feelings of being less powerless and more confident, connection with others, and completion of an advance directive. Qualitative analysis of responses to an open-ended postintervention question supported the quantitative findings.Conclusions: Peer-to-Peer is a promising self-help modality that warrants additional evaluation with more rigorous methodology.
SN - 1075-2730
AD - Center for Mental Health Services Research, University of Maryland, Baltimore, 737 West Lombard St., Room 258, Baltimore, MD 21201, USA
AD - Center for Mental Health Services Research, University of Maryland, Baltimore, 737 West Lombard St., Room 258, Baltimore, MD 21201, USA. aluckste@psych.umaryland.edu
U2 - PMID: 19176421.
DO - 10.1176/appi.ps.60.2.250
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105469969&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Selim, Alfredo J.
AU - Rogers, William
AU - Fleishman, John A.
AU - Qian, Shirley X.
AU - Fincke, Benjamin G.
AU - Rothendler, James A.
AU - Kazis, Lewis E.
T1 - Updated U.S. population standard for the Veterans RAND 12-item Health Survey (VR-12).
JO - Quality of Life Research
JF - Quality of Life Research
Y1 - 2009/02//
VL - 18
IS - 1
M3 - Article
SP - 43
EP - 52
PB - Springer Science & Business Media B.V.
SN - 09629343
AB - The purpose of this project was to develop an updated U.S. population standard for the Veterans RAND 12-item Health Survey (VR-12). We used a well-defined and nationally representative sample of the U.S. population from 52,425 responses to the Medical Expenditure Panel Survey (MEPS) collected between 2000 and 2002. We applied modified regression estimates to update the non-proprietary 1990 scoring algorithms. We applied the updated standard to the Medicare Health Outcomes Survey (HOS) to compute the VR-12 physical (PCS(MEPS standard)) and mental (MCS(MEPS standard)) component summaries based on the MEPS. We compared these scores to PCS and MCS based on the 1990 U.S. population standard. Using the updated U.S. population standard, the average VR-12 PCS(MEPS standard) and MCS(MEPS standard) scores in the Medicare HOS were 39.82 (standard deviation [SD] = 12.2) and 50.08 (SD = 11.4), respectively. For the same Medicare HOS, the average PCS and MCS scores based on the 1990 standard were 1.40 points higher and 0.99 points lower in comparison to VR-12 PCS and MCS, respectively. Changes in the U.S. population between 1990 and today make the old standard obsolete for the VR-12, so the updated standard developed here is widely available to serve as such a contemporary standard for future applications for health-related quality of life (HRQoL) assessments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Quality of Life Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERANS
KW - HEALTH surveys
KW - POPULATION
KW - ALGORITHMS
KW - UNITED States
KW - Health-related quality of life
KW - Standard-based scoring
KW - Veterans
KW - Veterans RAND 12-item Health Survey
N1 - Accession Number: 36327213; Selim, Alfredo J. 1,2,3,4; Email Address: Selim.AlfredoJ@Boston.Med.VA.gov Rogers, William 1,5 Fleishman, John A. 6 Qian, Shirley X. 1 Fincke, Benjamin G. 1,2,4 Rothendler, James A. 1,2 Kazis, Lewis E. 1,2; Email Address: lek@bu.edu; Affiliation: 1: Center for Health Quality, Outcomes, and Economic Research, A Health Services Research and Development Center of Excellence, VA Medical Center, Bedford, MA, USA 2: Center for the Assessment of Pharmaceutical Practices (CAPP), Department of Health Policy and Management, Boston University School of Public Health, 715 Albany Street, T3W, Boston, MA 02118, USA 3: Section of Emergency Services, Boston VA Health Care System, West Roxbury, MA, USA 4: Boston University School of Medicine, Boston, MA, USA 5: Health Institute, New England Medical Center, Boston, MA, USA 6: Center for Financing, Access, and Cost Trends (CFACT), Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Feb2009, Vol. 18 Issue 1, p43; Subject Term: VETERANS; Subject Term: HEALTH surveys; Subject Term: POPULATION; Subject Term: ALGORITHMS; Subject Term: UNITED States; Author-Supplied Keyword: Health-related quality of life; Author-Supplied Keyword: Standard-based scoring; Author-Supplied Keyword: Veterans; Author-Supplied Keyword: Veterans RAND 12-item Health Survey; NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 10p; Illustrations: 1 Diagram, 6 Charts; Document Type: Article
L3 - 10.1007/s11136-008-9418-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36327213&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wheeler, Matthew W.
AU - Bailer, A. John
T1 - Benchmark Dose Estimation Incorporating Multiple Data Sources.
JO - Risk Analysis: An International Journal
JF - Risk Analysis: An International Journal
Y1 - 2009/02//
VL - 29
IS - 2
M3 - Article
SP - 249
EP - 256
PB - Wiley-Blackwell
SN - 02724332
AB - With the increased availability of toxicological hazard information arising from multiple experimental sources, risk assessors are often confronted with the challenge of synthesizing all available scientific information into an analysis. This analysis is further complicated because significant between-source heterogeneity/lab-to-lab variability is often evident. We estimate benchmark doses using hierarchical models to account for the observed heterogeneity. These models are used to construct source-specific and population-average estimates of the benchmark dose (BMD). This is illustrated with an analysis of the U.S. EPA Region IX's reference toxicity database on the effects of sodium chloride on reproduction in Ceriodaphnia dubia. Results show that such models may effectively account for the lab-source heterogeneity while producing BMD estimates that more truly reflect the variability of the system under study. Failing to account for such heterogeneity may result in estimates having confidence intervals that are overly narrow. [ABSTRACT FROM AUTHOR]
AB - Copyright of Risk Analysis: An International Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Health risk assessment
KW - Hazardous substances
KW - Environmental health
KW - Risk assessment
KW - Risk
KW - Statistics
KW - Aquatic toxicology
KW - Bayesian methods
KW - generalized linear mixed models
KW - hierarchical models
KW - lab-to-lab variability
KW - Poisson responses
N1 - Accession Number: 36219063; Wheeler, Matthew W. 1; Bailer, A. John 2; Email Address: baileraj@muohio.edu; Affiliations: 1: National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH, USA; 2: Department of Mathematics and Statistics, Miami University, Oxford, OH, USA; Issue Info: Feb2009, Vol. 29 Issue 2, p249; Thesaurus Term: Health risk assessment; Thesaurus Term: Hazardous substances; Thesaurus Term: Environmental health; Thesaurus Term: Risk assessment; Subject Term: Risk; Subject Term: Statistics; Author-Supplied Keyword: Aquatic toxicology; Author-Supplied Keyword: Bayesian methods; Author-Supplied Keyword: generalized linear mixed models; Author-Supplied Keyword: hierarchical models; Author-Supplied Keyword: lab-to-lab variability; Author-Supplied Keyword: Poisson responses; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1539-6924.2008.01144.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36219063&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mark Stephenson
T1 - Hearing Protection in the 21st Century: They're Not Your Father's Earplugs Anymore.
JO - Seminars in Hearing
JF - Seminars in Hearing
Y1 - 2009/02//
VL - 30
IS - 1
M3 - Article
SP - 056
EP - 064
SN - 07340451
AB - Noise-induced hearing loss is one of the most common occupational illnesses among American workers. This is particularly tragic because this type of hearing loss can be prevented. When engineering or administrative controls have not eliminated a given hearing hazard, wearing hearing protectors remains the best way to prevent noise-induced hearing loss. Over the past several decades, technology has greatly improved hearing protector capabilities. Nevertheless, many workers fail to wear hearing protectors because they do not know when and how they should be worn. Applying health communication theory to develop hearing protection training can substantially improve attitudes, beliefs, and behaviors associated with hearing protector use. This article discusses how to identify barriers to hearing protector use, as well as how to promote self-efficacy as a means for improving hearing protector effectiveness. [ABSTRACT FROM AUTHOR]
AB - Copyright of Seminars in Hearing is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEARING protection
KW - NOISE-induced deafness
KW - OCCUPATIONAL diseases
KW - AUDIOLOGY
KW - SELF-efficacy
KW - HEARING aids
N1 - Accession Number: 46876782; Mark Stephenson 1; Affiliation: 1: Senior Research Audiologist, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Source Info: Feb2009, Vol. 30 Issue 1, p056; Subject Term: HEARING protection; Subject Term: NOISE-induced deafness; Subject Term: OCCUPATIONAL diseases; Subject Term: AUDIOLOGY; Subject Term: SELF-efficacy; Subject Term: HEARING aids; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; Number of Pages: 9p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=46876782&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105456792
T1 - Hearing protection in the 21st century: they're not your father's earplugs anymore.
AU - Stephenson MR
Y1 - 2009/02//
N1 - Accession Number: 105456792. Language: English. Entry Date: 20090703. Revision Date: 20150820. Publication Type: Journal Article; pictorial; tables/charts. Note: For CE see pages C-1-7. Journal Subset: Allied Health; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Speech-Language Pathology/Audiology. NLM UID: 8413380.
KW - Assistive Technology
KW - Ear Protective Devices -- Utilization
KW - Hearing Loss, Noise-Induced -- Prevention and Control
KW - Occupational Safety -- Education
KW - Teaching Materials
KW - Teaching Methods
KW - Ajzen-Fishbein Theory of Reasoned Action
KW - Blue Collar Workers
KW - Comfort
KW - Communication
KW - Dose-Response Relationship
KW - Ear Protective Devices -- Trends
KW - Economics
KW - Education, Continuing (Credit)
KW - Employee Attitudes
KW - Health Belief Model
KW - Health Promotion
KW - Motivation
KW - National Institute for Occupational Safety and Health
KW - Organizational Culture
KW - Self-Efficacy
KW - Transtheoretical Stages of Change Model
SP - 56
EP - 64
JO - Seminars in Hearing
JF - Seminars in Hearing
JA - SEMIN HEAR
VL - 30
IS - 1
CY - New York, New York
PB - Thieme Medical Publishing Inc.
AB - Noise-induced hearing loss is one of the most common occupational illnesses among American workers. This is particularly tragic because this type of hearing loss can be prevented. When engineering or administrative controls have not eliminated a given hearing hazard, wearing hearing protectors remains the best way to prevent noise-induced hearing loss. Over the past several decades, technology has greatly improved hearing protector capabilities. Nevertheless, many workers fail to wear hearing protectors because they. do not know when and how they should be worn. Applying health communication theory to develop hearing protection training can substantially improve attitudes, beliefs, and behaviors associated with hearing protector use. This article discusses how to identify barriers to hearing protector use, as well as how to promote self-efficacy as a means for improving hearing protector effectiveness.
SN - 0734-0451
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Mail Stop C-27, Cincinnati, OH 45226; e-mail: mstephenson@cdc.gov
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105456792&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hernán, Miguel A.
AU - McAdams, Mara
AU - McGrath, Nuala
AU - Lanoy, Emilie
AU - Costagliola, Dominique
T1 - Observation plans in longitudinal studies with time-varying treatments.
JO - Statistical Methods in Medical Research
JF - Statistical Methods in Medical Research
Y1 - 2009/02//
VL - 18
IS - 1
M3 - Article
SP - 27
EP - 52
PB - Sage Publications, Ltd.
SN - 09622802
AB - The article discusses the biases that may arise in interval cohorts with static observation plans. It explores the system of longitudinal studies, in which individuals are followed over time and their time-varying information on treatment is collected at certain intervals. It explains that biases rise as the observation regime or plan varies across individuals in many observational studies. It stresses another fact which states that intervals are dependent on an individual's clinical history.
KW - LONGITUDINAL method
KW - MEDICAL statistics
KW - MEDICAL research
KW - COHORT analysis
KW - CASE method (Teaching)
N1 - Accession Number: 36208949; Hernán, Miguel A. 1; Email Address: miguelhernan@post.harvard.edu McAdams, Mara 2 McGrath, Nuala 3 Lanoy, Emilie 4 Costagliola, Dominique 4; Affiliation: 1: Department of Epidemiology, Harvard School of Public Health and Harvard-MIT Division of Health Sciences and Technology, 2: Food and Drug Administration 3: London School of Hygiene & Tropical Medicine 4: U720 INSERM and Université Pierre et Marie Curie; Source Info: Feb2009, Vol. 18 Issue 1, p27; Subject Term: LONGITUDINAL method; Subject Term: MEDICAL statistics; Subject Term: MEDICAL research; Subject Term: COHORT analysis; Subject Term: CASE method (Teaching); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 26p; Illustrations: 7 Diagrams; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36208949&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-02150-001
AN - 2009-02150-001
AU - Cook, Benjamin Lê
AU - McGuire, Thomas G.
AU - Zuvekas, Samuel H.
T1 - Measuring trends in racial/ethnic health care disparities.
JF - Medical Care Research and Review
JO - Medical Care Research and Review
JA - Med Care Res Rev
Y1 - 2009/02//
VL - 66
IS - 1
SP - 23
EP - 48
CY - US
PB - Sage Publications
SN - 1077-5587
SN - 1552-6801
N1 - Accession Number: 2009-02150-001. PMID: 18796581 Other Journal Title: Medical Care Review. Partial author list: First Author & Affiliation: Cook, Benjamin Lê; Cambridge Health Alliance, Harvard Medical School, Somerville, MA, US. Release Date: 20091026. Correction Date: 20091123. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Minority Groups; Racial and Ethnic Differences; Trends; Health Disparities. Minor Descriptor: Health; Socioeconomic Status; Status. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 26. Issue Publication Date: Feb, 2009. Publication History: Accepted Date: Jun 20, 2008; Revised Date: Mar 4, 2008. Copyright Statement: Sage Publications. 2009.
AB - Monitoring disparities over time is complicated by the varying disparity definitions applied in the literature. This study used data from the 1996-2005 Medical Expenditure Panel Survey (MEPS) to compare trends in disparities by three definitions of racial/ethnic disparities and to assess the influence of changes in socioeconomic status (SES) among racial/ethnic minorities on disparity trends. This study prefers the Institute of Medicine’s (IOM) definition, which adjusts for health status but allows for mediation of racial/ethnic disparities through SES factors. Black–White disparities in having an office-based or outpatient visit and medical expenditure were roughly constant and Hispanic–White disparities increased for office-based or outpatient visits and for medical expenditure between 1996-1997 and 2004-2005. Estimates based on the independent effect of race/ethnicity were the most conservative accounting of disparities and disparity trends, underlining the importance of the role of SES mediation in the study of trends in disparities. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - trend measurement
KW - racial health care disparities
KW - socioeconomic status
KW - ethnic minorities
KW - health status
KW - 2009
KW - Minority Groups
KW - Racial and Ethnic Differences
KW - Trends
KW - Health Disparities
KW - Health
KW - Socioeconomic Status
KW - Status
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: P50 MHO 73469; R03 MH82312. Recipients: No recipient indicated
U1 - Sponsor: National Center on Minority Health and Health Disparities, US. Grant: P60 MD002261. Recipients: No recipient indicated
DO - 10.1177/1077558708323607
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02150-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01564-005
AN - 2009-01564-005
AU - Unruh, Lynn
AU - Russo, C. Allison
AU - Jiang, H. Joanna
AU - Stocks, Carol
T1 - Can state databases be used to develop a national, standardized hospital nurse staffing database?
JF - Western Journal of Nursing Research
JO - Western Journal of Nursing Research
JA - West J Nurs Res
Y1 - 2009/02//
VL - 31
IS - 1
SP - 66
EP - 88
CY - US
PB - Sage Publications
SN - 0193-9459
SN - 1552-8456
AD - Unruh, Lynn
N1 - Accession Number: 2009-01564-005. PMID: 18667627 Partial author list: First Author & Affiliation: Unruh, Lynn; University of Central Florida, Orlando, FL, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Data Collection; Databases; Hospitals; Nurses; Human Resource Management. Minor Descriptor: Nursing. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: Feb, 2009. Copyright Statement: Sage Publications. 2009.
AB - This study evaluates the feasibility of building a national, standardized hospital nurse staffing database from state data collections in order to improve the availability of valid, reliable nursing staffing measures and to allow linkage to other databases. A state-by-state review of public and private reporting systems reveals that 25 states collect some form of nurse staffing data. Out of those, 12 states make complete, usable data available, and 5 additionally meet data quality and specificity criteria. Our review finds that there is little consistency in the content of the RN measure, which makes it difficult to conduct multistate research on nurse staffing topics. We recommend the long-term development of two types of nurse staffing databases: a state-by-state collection, and a standardized, multistate database with uniform data elements across states. This mixed approach will provide a comprehensive source of nurse staffing data to researchers with diverse analytic needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - state databases
KW - standardized hospital nurse staffing databases
KW - national databases
KW - data collections
KW - nursing staffing measures
KW - 2009
KW - Data Collection
KW - Databases
KW - Hospitals
KW - Nurses
KW - Human Resource Management
KW - Nursing
KW - 2009
U1 - Sponsor: Agency for Healthcare Research and Quality. Recipients: No recipient indicated
DO - 10.1177/0193945908319992
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01564-005&site=ehost-live&scope=site
UR - Lunruh@mail.ucf.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00722-006
AN - 2009-00722-006
AU - Li, Yue
AU - Cai, Xueya
AU - Glance, Laurent G.
AU - Spector, William D.
AU - Mukamel, Dana B.
T1 - National release of the nursing home quality report cards: Implications of statistical methodology for risk adjustment.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2009/02//
VL - 44
IS - 1
SP - 79
EP - 102
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - Li, Yue, Department of Medicine, University of California, Irvine, CA, US, 92697
N1 - Accession Number: 2009-00722-006. PMID: 19146565 Partial author list: First Author & Affiliation: Li, Yue; Department of Medicine, University of California, Irvine, CA, US. Other Publishers: Blackwell Publishing. Release Date: 20091130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Li, Yue. Major Descriptor: Nursing Homes; Quality Control. Minor Descriptor: Methodology; Risk Assessment. Classification: Nursing Homes & Residential Care (3377). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Tests & Measures: Minimum Data Set. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 24. Issue Publication Date: Feb, 2009. Copyright Statement: Health Research and Educational Trust
AB - Objective: To determine how alternative statistical risk-adjustment methods may affect the quality measures (QMs) in nursing home (NH) report cards. Data Sources/Study Settings: Secondary data from the national Minimum Data Set files of 2004 and 2005 that include 605,433 long-term residents in 9,336 facilities. Study Design: We estimated risk-adjusted QMs of decline in activities of daily living (ADL) functioning using classical, fixed-effects, and random-effects logistic models. Risk-adjusted QMs were compared with each other, and with the published QM (unadjusted) in identifying high- and low-quality facilities by either the rankings or 95 percent confidence intervals of QMs. Principal Findings: Risk-adjusted QMs showed better overall agreement (or convergent validity) with each other than did the unadjusted versus each adjusted QM; the disagreement rate between unadjusted and adjusted QM can be as high as 48 percent. The risk-adjusted QM derived from the random-effects shrinkage estimator deviated nonrandomly from other risk-adjusted estimates in identifying the best 10 percent facilities using rankings. Conclusions: The extensively risk-adjusted QMs of ADL decline, even when estimated by alternative statistical methods, show higher convergent validity and provide more robust NH comparisons than the unadjusted QM. Outcome rankings based on ADL decline tend to show lower convergent validity when estimated by the shrinkage estimator rather than other statistical methods. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nursing home quality report cards
KW - statistical methodology
KW - risk adjustment
KW - 2009
KW - Nursing Homes
KW - Quality Control
KW - Methodology
KW - Risk Assessment
KW - 2009
U1 - Sponsor: National Institute on Aging, US. Grant: AG029608. Recipients: Li, Yue
U1 - Sponsor: National Institute on Aging, US. Grant: AG020644. Recipients: Mukamel, Dana B.
DO - 10.1111/j.1475-6773.2008.00910.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00722-006&site=ehost-live&scope=site
UR - ylill@uci.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01223-007
AN - 2009-01223-007
AU - Zhang, Yuanting
AU - Van Hook, Jennifer
T1 - Marital dissolution among interracial couples.
JF - Journal of Marriage and Family
JO - Journal of Marriage and Family
JA - J Marriage Fam
Y1 - 2009/02//
VL - 71
IS - 1
SP - 95
EP - 107
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0022-2445
SN - 1741-3737
AD - Zhang, Yuanting
N1 - Accession Number: 2009-01223-007. PMID: 25284887 Other Journal Title: Journal of Marriage and the Family; Living; Marriage and Family Living. Partial author list: First Author & Affiliation: Zhang, Yuanting; Food and Drug Administration, US. Other Publishers: National Council on Family Relations. Release Date: 20090706. Correction Date: 20120326. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Couples; Divorce; Interracial Marriage; Marital Conflict; Racial and Ethnic Groups. Classification: Marriage & Family (2950). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Feb, 2009.
AB - Increases in interracial marriage have been interpreted as reflecting reduced social distance among racial and ethnic groups, but little is known about the stability of interracial marriages. Using six panels of Survey of Income and Program Participation (N = 23,139 married couples), we found that interracial marriages are less stable than endogamous marriages, but these findings did not hold up consistently. After controlling for couple characteristics, the risk of divorce or separation among interracial couples was similar to the more-divorce-prone origin group. Although marital dissolution was found to be strongly associated with race or ethnicity, the results failed to provide evidence that interracial marriage per se is associated with an elevated risk of marital dissolution. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - marital dissolution
KW - interracial couples
KW - racial groups
KW - ethnic groups
KW - social distance
KW - interracial marriages
KW - marriage stability
KW - 2009
KW - Couples
KW - Divorce
KW - Interracial Marriage
KW - Marital Conflict
KW - Racial and Ethnic Groups
KW - 2009
DO - 10.1111/j.1741-3737.2008.00582.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01223-007&site=ehost-live&scope=site
UR - zhangyuant@gmail.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00617-005
AN - 2009-00617-005
AU - Davis, Maryann
AU - Fisher, William H.
AU - Gershenson, Bernice
AU - Grudzinskas, Albert J.
AU - Banks, Steven M.
T1 - Justice system involvement into young adulthood: Comparison of adolescent girls in the public mental health system and in the general population.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/02//
VL - 99
IS - 2
SP - 234
EP - 236
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Davis, Maryann, Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA, US, 01655
N1 - Accession Number: 2009-00617-005. PMID: 19059845 Partial author list: First Author & Affiliation: Davis, Maryann; Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Criminal Justice; Human Females; Legal Arrest; Mental Health Services. Minor Descriptor: Public Health Services. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Feb, 2009. Publication History: Accepted Date: Jul 5, 2008.
AB - We compared arrest onset and frequency and types of charges between a statewide cohort of adolescent girls in the public mental health system and girls of the same age in the general population to investigate important differences that could have policy or intervention implications. Girls in the public mental health system were arrested at earlier ages more frequently and were charged with more serious offenses than were girls in the general population. Our results strongly argue for cooperation between the public mental health and justice systems to provide mental health and offender rehabilitation in their shared population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - criminal justice systems
KW - young girls
KW - arrest rates
KW - public mental health system
KW - 2009
KW - Criminal Justice
KW - Human Females
KW - Legal Arrest
KW - Mental Health Services
KW - Public Health Services
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH067862-01A1. Recipients: No recipient indicated
DO - 10.2105/AJPH.2008.141135
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00617-005&site=ehost-live&scope=site
UR - maryann.davis@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-00617-007
AN - 2009-00617-007
AU - Mofidi, Mahyar
AU - Zeldin, Leslie P.
AU - Rozier, R. Gary
T1 - Oral health of early head start children: A qualitative study of staff, parents, and pregnant women.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/02//
VL - 99
IS - 2
SP - 245
EP - 251
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Mofidi, Mahyar, United States Public Health Service, Health Resources and Services Administration, HIV/AIDS Bureau, 5600 Fisher Lane, Room 7A-15, Rockville, MD, US, 20857
N1 - Accession Number: 2009-00617-007. PMID: 19059853 Partial author list: First Author & Affiliation: Mofidi, Mahyar; School of Dentistry and Public Health, University of North Carolina, Chapel Hill, NC, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Attitudes; Health Education; Health Knowledge; Project Head Start; Oral Health. Minor Descriptor: Intervention. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Feb, 2009. Publication History: Accepted Date: Jun 10, 2008.
AB - Objectives: We explored the oral health knowledge, attitudes, and activities of Early Head Start (EHS) staff members, parents, and pregnant women, along with their suggestions related to future oral health educational interventions targeting EHS children. Methods: Nine focus groups were conducted with EHS staff, parents, and pregnant women. Audiotapes of sessions were transcribed and entered into ATLAS.ti 5.0 for coding and analysis. Results: Attitudes about the importance of children's oral health among parents and pregnant women were mixed. Staff members voiced responsibility for children's oral health but frustration in their inability to communicate effectively with parents. Parents in turn perceived staff criticism regarding how they cared for their children's oral health. Gaps were noted in the oral health activities of EHS programs. Participants expressed confusion regarding the application of Head Start oral health performance standards to EHS. The need for culturally sensitive, hands-on oral health education was highlighted. Conclusions: Tailored, theory-based interventions are needed to improve communication between EHS staff and families. Clear policies on the application of Head Start oral health performance standards to EHS are warranted. Educational activities should address the needs and suggestions of EHS participants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oral health
KW - health knowledge
KW - health attitudes
KW - Early Head Start
KW - health educational interventions
KW - 2009
KW - Health Attitudes
KW - Health Education
KW - Health Knowledge
KW - Project Head Start
KW - Oral Health
KW - Intervention
KW - 2009
U1 - Sponsor: Centers Formedicare and Medicaid Services. Recipients: No recipient indicated
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: 11-P-91251/5. Recipients: No recipient indicated
DO - 10.2105/AJPH.2008.133827
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-00617-007&site=ehost-live&scope=site
UR - mmofidi@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-01491-017
AN - 2009-01491-017
AU - Lucksted, Alicia
AU - McNulty, Kathryn
AU - Brayboy, Lorener
AU - Forbes, Courtney
T1 - Initial evaluation of the peer-to-peer program.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/02//
VL - 60
IS - 2
SP - 250
EP - 253
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Lucksted, Alicia, Center for Mental Health Services Research, University of Maryland, Baltimore, 737 West Lombard St., Room 258, Baltimore, MD, US, 21201
N1 - Accession Number: 2009-01491-017. PMID: 19176421 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Lucksted, Alicia; Center for Mental Health Services Research, University of Maryland, Baltimore, Baltimore, MD, US. Release Date: 20090706. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: NAMI national convention, Jun-Jul, 2006, Washington, DC, US. Conference Note: An earlier version of this report was presented at the aforementioned conference. Major Descriptor: Empowerment; Mental Disorders; Program Evaluation; Relapse Prevention. Minor Descriptor: Emotions; Peer Relations. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 4. Issue Publication Date: Feb, 2009.
AB - Objective: Peer-to-Peer, sponsored by the National Alliance on Mental Illness (NAMI), is a structured, experiential, self-empowerment, relapse prevention and wellness program led by trained peer mentors for people with mental illnesses. The authors conducted the first empirical evaluation of the program by using a pre-post survey design. Methods: Approximately 550 participants who were enrolled in Peer-to- Peer during the data collection period (2005–2006) were invited to complete a brief, anonymous survey before participating in the program and immediately after. Results: Analyses of responses from 138 participants indicated that they gained significant benefits, especially in areas central to the Peer-to-Peer curriculum—specifically, knowledge and management of their illness, feelings of being less powerless and more confident, connection with others, and completion of an advance directive. Qualitative analysis of responses to an open-ended postintervention question supported the quantitative findings. Conclusions: Peer-to-Peer is a promising self-help modality that warrants additional evaluation with more rigorous methodology. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - initial evaluation
KW - peer-to-peer program
KW - mental illness
KW - self-empowerment
KW - relapse prevention
KW - feelings
KW - 2009
KW - Empowerment
KW - Mental Disorders
KW - Program Evaluation
KW - Relapse Prevention
KW - Emotions
KW - Peer Relations
KW - 2009
U1 - Sponsor: NAMI, National Office. Other Details: The University of Maryland. Recipients: No recipient indicated
U1 - Sponsor: AstraZeneca. Other Details: NAMI’s; Unrestricted educational grant. Recipients: No recipient indicated
DO - 10.1176/appi.ps.60.2.250
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-01491-017&site=ehost-live&scope=site
UR - aluckste@psych.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-00478-018
AN - 2010-00478-018
AU - Mosholder, Andrew D.
AU - Gelperin, Kate
AU - Hammad, Tarek A.
AU - Phelan, Kathleen
AU - Johann-Liang, Rosemary
T1 - Hallucinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/02//
VL - 123
IS - 2
SP - 611
EP - 616
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Gelperin, Kate, 10903 New Hampshire Ave, Building 22, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2010-00478-018. PMID: 19171629 Partial author list: First Author & Affiliation: Mosholder, Andrew D.; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Attention Deficit Disorder with Hyperactivity; CNS Stimulating Drugs; Drug Therapy; Hallucinations; Psychiatric Symptoms. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Clinical Trial; Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Feb, 2009. Publication History: Accepted Date: May 30, 2008.
AB - Objectives: To gain a better understanding of the capacity of psychostimulant medications to induce adverse psychiatric reactions and determine the frequency of such reactions, we analyzed postmarketing surveillance data and clinical trial data for drugs, either approved or under development, for the treatment of attention-deficit/ hyperactivity disorder. Methods: The US Food and Drug Administration requested manufacturers of drugs approved for attention-deficit/hyperactivity disorder or with active clinical development programs for that indication to search their electronic clinical trial databases for cases of psychosis or mania using prespecified search terms. The manufacturers supplied descriptions of clinical trials, numbers of patients exposed to study drug, and duration of exposure to permit calculations of incidence rates. Independently, cases of psychosis or mania in children and adults for drugs used to treat attention-deficit/hyperactivity disorder from the Food and Drug Administration Adverse Event Reporting System safety database were analyzed. Manufacturers were asked to conduct similar analyses of their postmarketing surveillance databases. Results: We analyzed data from 49 randomized, controlled clinical trials in the pediatric development programs for these products. A total of 11 psychosis/mania adverse events occurred during 743 person-years of double-blind treatment with these drugs, and no comparable adverse events occurred in a total of 420 person-years of placebo exposure in the same trials. The rate per 100 person-years in the pooled active drug group was 1.48. The analysis of spontaneous postmarketing reports yielded >800 reports of adverse events related to psychosis or mania. In ~90% of the cases, there was no reported history of a similar psychiatric condition. Hallucinations involving visual and/or tactile sensations of insects, snakes, or worms were common in cases in children. Conclusions: Patients and physicians should be aware that psychosis or mania arising during drug treatment of attention-deficit/hyperactivity disorder may represent adverse drug reactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hallucinations
KW - psychotic symptoms
KW - attention-deficit/hyperactivity disorder drugs
KW - psychostimulant medications
KW - 2009
KW - Attention Deficit Disorder with Hyperactivity
KW - CNS Stimulating Drugs
KW - Drug Therapy
KW - Hallucinations
KW - Psychiatric Symptoms
KW - 2009
DO - 10.1542/peds.2008-0185
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-00478-018&site=ehost-live&scope=site
UR - kate.gelperin@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Janda, Michel
AU - Buch, Barbara
T1 - The Challenges of Clinical Validation of Emerging Technologies: Computer-Assisted Devices for Surgery.
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
Y1 - 2009/02/02/Feb2009 Supplement 1
VL - 91
IS - S1
M3 - Article
SP - 17
EP - 21
SN - 00219355
AB - Over the last decade, the use of computers and robotics in medicine has increased commensurate with emergent advances in technology. This article largely focuses on the challenges that the U.S. Food and Drug Administration faces when evaluating new technologies for entry into the market. How different categories of devices are categorized and what types of data have been used for regulatory approval or clearance are described. These are compared with expectations that the clinical community may have for these devices. A brief discussion of current regulatory thinking about these types of devices is also included. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bone & Joint Surgery, American Volume is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER-assisted orthopedic surgery
KW - TECHNOLOGICAL innovations
KW - REGULATED industries
KW - ROBOTICS in medicine
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36656913; Janda, Michel 1 Buch, Barbara 1; Affiliation: 1: Division of General Restorative and Neurological Devices, Center for Devices and Radiologic Health, U.S. Food and Drug Administration, 9200 Corporate Boulevard, HFZ-410, Rockville, MD 20850.; Source Info: Feb2009 Supplement 1, Vol. 91 Issue S1, p17; Subject Term: COMPUTER-assisted orthopedic surgery; Subject Term: TECHNOLOGICAL innovations; Subject Term: REGULATED industries; Subject Term: ROBOTICS in medicine; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36656913&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105464288
T1 - The challenges of clinical validation of emerging technologies: computer-assisted devices for surgery.
AU - Janda M
AU - Buch B
AU - Janda, Michel
AU - Buch, Barbara
Y1 - 2009/02/02/Feb2009 Supplement 1
N1 - Accession Number: 105464288. Language: English. Entry Date: 20090327. Revision Date: 20160517. Publication Type: journal article; research. Supplement Title: Feb2009 Supplement 1. Journal Subset: Biomedical; Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0014030.
KW - Orthopedic Surgery -- Equipment and Supplies
KW - Therapy, Computer Assisted -- Equipment and Supplies
KW - Device Approval
KW - Validation Studies
KW - Human
SP - 17
EP - 21
JO - Journal of Bone & Joint Surgery, American Volume
JF - Journal of Bone & Joint Surgery, American Volume
JA - J BONE JOINT SURG (AM)
VL - 91
IS - S1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Over the last decade, the use of computers and robotics in medicine has increased commensurate with emergent advances in technology. This article largely focuses on the challenges that the U.S. Food and Drug Administration faces when evaluating new technologies for entry into the market. How different categories of devices are categorized and what types of data have been used for regulatory approval or clearance are described. These are compared with expectations that the clinical community may have for these devices. A brief discussion of current regulatory thinking about these types of devices is also included.
SN - 0021-9355
AD - Division of General Restorative and Neurological Devices, Center for Devices and Radiologic Health, U.S. Food and Drug Administration, 9200 Corporate Boulevard, HFZ-410, Rockville, MD 20850, USA
AD - Division of General Restorative and Neurological Devices, Center for Devices and Radiologic Health, U.S. Food and Drug Administration, 9200 Corporate Boulevard, HFZ-410, Rockville, MD 20850, USA.
U2 - PMID: 19182016.
DO - 10.2106/JBJS.H.01337
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105464288&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - SPAULDING, ANNE C.
AU - JACOB ARRIOLA, KIMBERLY R.
AU - HAMMETT, THEODORE
AU - KENNEDY, SOFIA
AU - TINSLEY, MELINDA
T1 - Rapid HIV Testing In Rapidly Released Detainees: Next Steps.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2009/02/02/Feb2009 Supplement
VL - 36
M3 - Editorial
SP - S34
EP - S36
SN - 01485717
AB - The article reflects on the Center for Disease Control and Prevention (CDC) Rapid HIV Testing in Jail Demonstration Project and rapi HIV testing in jails. He states that after the success of the CDC demonstration project at demonstrating that rapid testing is feasible in jails, the challenge to prisons, public health departments, and acquired immune deficiency syndrome service organizations is to fill the gaps in knowledge on how to operationalize rapid HIV testing in jails on a larger scale.
KW - HIV infections -- Prevention
KW - AIDS (Disease) -- Prevention
KW - JAILS
KW - PRISONS
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 36503559; SPAULDING, ANNE C. 1; Email Address: Aspauld@emory.edu JACOB ARRIOLA, KIMBERLY R. 1 HAMMETT, THEODORE 2 KENNEDY, SOFIA 2 TINSLEY, MELINDA 3; Affiliation: 1: Rollins School of Public Health, Emory University, Atlanta, Georgia 2: Abt Associates Incorporated, Cambridge, Massachusetts 3: Health Resources and Services Administration, HIV/AIDS Bureau, Special Projects of National Significance (SPNS), Rockville, Maryland; Source Info: Feb2009 Supplement, Vol. 36, pS34; Subject Term: HIV infections -- Prevention; Subject Term: AIDS (Disease) -- Prevention; Subject Term: JAILS; Subject Term: PRISONS; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 913120 Municipal correctional services; NAICS/Industry Codes: 912120 Provincial correctional services; NAICS/Industry Codes: 922140 Correctional Institutions; NAICS/Industry Codes: 236220 Commercial and Institutional Building Construction; NAICS/Industry Codes: 911220 Federal correctional services; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1097/OLQ.0b013e3180959e9f
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36503559&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Tai, Eric
AU - Miller, Therese
T1 - Screening for Skin Cancer: An Update of the Evidence for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/02/03/
VL - 150
IS - 3
M3 - Article
SP - 194
EP - 198
SN - 00034819
AB - Background: Skin cancer is the most commonly diagnosed cancer in the United States. The majority of skin cancer is nonmelanoma cancer, either basal cell cancer or squamous cell cancer. The incidence of both melanoma and nonmelanoma skin cancer has been increasing over the past 3 decades. In 2001, the U.S. Preventive Services Task Force (USPSTF) found insufficient evidence to recommend for or against routine screening for skin cancer by using whole-body skin examination for early detection of skin cancer. Purpose: To update the evidence of benefits and harms of screening for skin cancer in the general population. Data Sources: MEDLINE and Cochrane Library searches from 1 June 1999 to 9 August 2005 for English-language articles; recent systematic reviews; reference lists of retrieved articles; and expert suggestions. Study Selection: English-language studies were selected to answer the following key question: Does screening in asymptomatic persons with whole-body examination by a primary care clinician or by self-examination reduce morbidity and mortality from skin cancer? Randomized, controlled trials and case-control studies of screening for skin cancer were selected. One author selected English-language studies to answer the following contextual questions: Can screening with whole-body examination by primary care clinicians or by self-examination accurately detect skin cancer? Does screening with whole-body examination or by self-examination detect melanomas at an earlier stage (thinner lesions)? Data Extraction: All studies for the key question were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: No new evidence from controlled studies was found that addressed the benefit of screening for skin cancer with a whole-body examination by a physician. One article of fair quality, which reanalyzed data from a 1996 study identified for the 2001 report for the USPSTF, provides limited but insufficient evidence on the benefit of skin self-examination in the reduction of morbidity and mortality from melanoma. Limitations: Direct evidence linking skin cancer screening to improved health outcomes is lacking. Information is limited on the accuracy of screening by physicians or patients using real patients and lesions. Conclusion: The limited evidence prevents accurate estimation of the benefits of screening for skin cancer in the general primary care population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN -- Cancer
KW - PATIENTS
KW - MEDICAL screening
KW - HEALTH risk assessment
KW - PRIMARY care (Medicine)
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 36380742; Wolff, Tracy 1 Tai, Eric 2 Miller, Therese 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, Northeast, MS-K57, Atlanta, GA 30341-3717; Source Info: 2/3/2009, Vol. 150 Issue 3, p194; Subject Term: SKIN -- Cancer; Subject Term: PATIENTS; Subject Term: MEDICAL screening; Subject Term: HEALTH risk assessment; Subject Term: PRIMARY care (Medicine); Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36380742&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Petitti, Diana B.
AU - Teutsch, Steven M.
AU - Barton, Mary B.
AU - Sawaya, George F.
AU - Ockene, Judith K.
AU - DeWitt, Thomas
T1 - Update on the Methods of the U.S. Preventive Services Task Force: Insufficient Evidence.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/02/03/
VL - 150
IS - 3
M3 - Article
SP - 199
EP - 205
SN - 00034819
AB - The U.S. Preventive Services Task Force (USPSTF) seeks to provide reliable and accurate evidence-based recommendations to primary care clinicians. However, clinicians indicate frustration with the lack of guidance provided by the USPSTF when the evidence is insufficient to make a recommendation. This article describes a new USPSTF plan to commission its Evidence-based Practice Centers to collect information in 4 domains pertinent to clinical decisions about prevention and to report this information routinely. The 4 domains are potential preventable burden, potential harm of the intervention, costs (both monetary and opportunity), and current practice. The process and rationale used to select these domains are presented, along with examples of how clinicians might use the information to guide clinical decision making when evidence is insufficient. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PRIMARY care (Medicine)
KW - NURSING assessment
KW - MEDICAL personnel
KW - DECISION making
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 36380743; Petitti, Diana B. 1 Teutsch, Steven M. 2 Barton, Mary B. 3 Sawaya, George F. 4 Ockene, Judith K. 5 DeWitt, Thomas 6; Affiliation: 1: Department of Biomedical Informatics, Arizona State University, Phoenix, AZ 85041 2: Outcomes Research, Merck & Co., West Point, PA 19486 3: Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, MD 20850 4: Department of Obstetrics, Gynecology and Reproductive Science, University of California, San Francisco, San Francisco, CA 94143 5: Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655 6: Department of Pediatrics, Cincinnati Children's, University of Cincinnati College of Medicine, Cincinnati, OH 452; Source Info: 2/3/2009, Vol. 150 Issue 3, p199; Subject Term: PRIMARY care (Medicine); Subject Term: NURSING assessment; Subject Term: MEDICAL personnel; Subject Term: DECISION making; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 7p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36380743&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Konety, Badrinath R.
AU - Cooperberg, Matthew R.
AU - Carroll, Peter R.
AU - Gogol, Manfred
AU - Calonge, Ned
AU - Petitti, Diana B.
AU - Lin, Kenneth W.
T1 - Are Age-Based Criteria the Best Way to Determine Eligibility for Prostate Cancer Screening?
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/02/03/
VL - 150
IS - 3
M3 - Letter
SP - 220
EP - 222
SN - 00034819
AB - Two letters to the editor are presented in response to the article about the medical recommendations provided by the U.S. Preventive Services Task Force (USPSTF) for prostate cancer screening.
KW - LETTERS to the editor
KW - MEDICAL screening
KW - PROSTATE cancer
KW - MEDICAL care
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 36380748; Konety, Badrinath R. 1 Cooperberg, Matthew R. 1 Carroll, Peter R. 1 Gogol, Manfred 2 Calonge, Ned 3 Petitti, Diana B. 4 Lin, Kenneth W. 5; Affiliation: 1: University of California, San Francisco, San Francisco, CA 94143 2: Krankenhaus Lindenbrunn, Klinik fuer Geriatrie, Coppenbruegge 31863, Germany 3: Colorado Department of Public Health and Environment, Denver, CO 80246 4: Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 5: Agency for Healthcare Research and Quality, Rockville, MD 20850; Source Info: 2/3/2009, Vol. 150 Issue 3, p220; Subject Term: LETTERS to the editor; Subject Term: MEDICAL screening; Subject Term: PROSTATE cancer; Subject Term: MEDICAL care; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105097383
T1 - Screening for skin cancer: an update of the evidence for the U.S. Preventive Services Task Force.
AU - Wolff T
AU - Tai E
AU - Miller T
Y1 - 2009/02/03/
N1 - Accession Number: 105097383. Language: English. Entry Date: 20100924. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Health Screening
KW - Skin Neoplasms -- Diagnosis
KW - Adult
KW - Aged
KW - Cochrane Library
KW - Early Detection of Cancer
KW - Female
KW - Human
KW - Male
KW - Medical Practice, Evidence-Based
KW - Medline
KW - Primary Health Care
KW - Research, Medical
KW - Risk Assessment
KW - Self Diagnosis
KW - Skin Neoplasms -- Prevention and Control
KW - Skin Neoplasms -- Therapy
KW - Systematic Review
SP - 194
EP - 198
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 150
IS - 3
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Skin cancer is the most commonly diagnosed cancer in the United States. The majority of skin cancer is nonmelanoma cancer, either basal cell cancer or squamous cell cancer. The incidence of both melanoma and nonmelanoma skin cancer has been increasing over the past 3 decades. In 2001, the U.S. Preventive Services Task Force (USPSTF) found insufficient evidence to recommend for or against routine screening for skin cancer by using whole-body skin examination for early detection of skin cancer. PURPOSE: To update the evidence of benefits and harms of screening for skin cancer in the general population. DATA SOURCES: MEDLINE and Cochrane Library searches from 1 June 1999 to 9 August 2005 for English-language articles; recent systematic reviews; reference lists of retrieved articles; and expert suggestions. STUDY SELECTION: English-language studies were selected to answer the following key question: Does screening in asymptomatic persons with whole-body examination by a primary care clinician or by self-examination reduce morbidity and mortality from skin cancer? Randomized, controlled trials and case-control studies of screening for skin cancer were selected. One author selected English-language studies to answer the following contextual questions: Can screening with whole-body examination by primary care clinicians or by self-examination accurately detect skin cancer? Does screening with whole-body examination or by self-examination detect melanomas at an earlier stage (thinner lesions)? DATA EXTRACTION: All studies for the key question were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. DATA SYNTHESIS: No new evidence from controlled studies was found that addressed the benefit of screening for skin cancer with a whole-body examination by a physician. One article of fair quality, which reanalyzed data from a 1996 study identified for the 2001 report for the USPSTF, provides limited but insufficient evidence on the benefit of skin self-examination in the reduction of morbidity and mortality from melanoma. LIMITATIONS: Direct evidence linking skin cancer screening to improved health outcomes is lacking. Information is limited on the accuracy of screening by physicians or patients using real patients and lesions. CONCLUSION: The limited evidence prevents accurate estimation of the benefits of screening for skin cancer in the general primary care population.
SN - 0003-4819
AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 19189909.
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DP - EBSCOhost
DB - rzh
ER -
TY - CONF
AU - Tondella, M.L.
AU - Carlone, G.M.
AU - Messonnier, N.
AU - Quinn, C.P.
AU - Meade, B.D.
AU - Burns, D.L.
AU - Cherry, J.D.
AU - Guiso, N.
AU - Hewlett, E.L.
AU - Edwards, K.M.
AU - Xing, D.
AU - Giammanco, A.
AU - Wirsing von König, C.H.
AU - Han, L.
AU - Hueston, L.
AU - Robbins, J.B.
AU - Powell, M.
AU - Mink, C.M.
AU - Poolman, J.T.
AU - Hildreth, S.W.
T1 - International Bordetella pertussis assay standardization and harmonization meeting report. Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 19–20 July 2007
JO - Vaccine
JF - Vaccine
Y1 - 2009/02/05/
VL - 27
IS - 6
M3 - Proceeding
SP - 803
EP - 814
SN - 0264410X
AB - Abstract: An international meeting on Bordetella pertussis assay standardization and harmonization was held at the Centers for Disease Control and Prevention (CDC), Atlanta, GA, 19–20 July 2007. The goal of the meeting was to harmonize the immunoassays used for pertussis diagnostics and vaccine evaluation, as agreed upon by academic and government researchers, regulatory authorities, vaccine manufacturers, and the World Health Organization (WHO). The primary objectives were (1) to provide epidemiologic, laboratory, and statistical background for support of global harmonization; (2) to overview the current status of global epidemiology, pathogenesis and immunology of pertussis; (3) to develop a consensus opinion on existing gaps in understanding standardization of pertussis assays used for serodiagnosis and vaccine evaluation; and (4) to search for a multicenter process for addressing these priority gaps. Presentations and discussions by content experts addressed these objectives. A prioritized list of action items to improve standardization and harmonization of pertussis assays was identified during a group discussion at the end of the meeting. The major items included: (1) to identify a group that will organize, prepare, maintain, and distribute proficiency panels and key reagents such as reference and control sera; (2) to encourage the development and identification of one or more reference laboratories that can serve as an anchor and resource for other laboratories; (3) to define a performance-based assay method that can serve as a reference point for evaluating laboratory differences; (4) to develop guidance on quality of other reagents, e.g., pertussis toxin and other antigens, and methods to demonstrate their suitability; (5) to establish an international working group to harmonize the criteria to evaluate the results obtained on reference and proficiency panel sera; (6) to create an inventory to determine the amount of appropriate and well-characterized sera that are available globally to be used as bridging reagents for vaccine licensure; and (7) to seek specific guidance from regulatory authorities regarding the expectations and requirements for the licensure of new multicomponent pertussis vaccines. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Epidemiology
KW - World health
KW - Medicine -- Congresses
KW - Immunoassay
KW - Bordetella pertussis
KW - Enzyme-linked immunosorbent assay
KW - Whooping cough
KW - Atlanta (Ga.)
KW - Georgia
KW - United States
KW - ELISA
KW - Pertussis vaccines
KW - Standardization of serologic assays
KW - Centers for Disease Control & Prevention (U.S.)
KW - World Health Organization
N1 - Accession Number: 36194430; Tondella, M.L. 1; Email Address: mtondella@cdc.gov; Carlone, G.M. 1; Messonnier, N. 1; Quinn, C.P. 1; Meade, B.D. 2; Burns, D.L. 3; Cherry, J.D. 4; Guiso, N. 5; Hewlett, E.L. 6; Edwards, K.M. 7; Xing, D. 8; Giammanco, A. 9; Wirsing von König, C.H. 10; Han, L. 11; Hueston, L. 12; Robbins, J.B. 13; Powell, M. 14; Mink, C.M. 15; Poolman, J.T. 16; Hildreth, S.W. 17; Affiliations: 1: Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, United States; 2: Meade Biologics LLC, 1500 Butterfly Place, Hillsborough, NC 27278, United States; 3: Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, MS HFM-434, 8800 Rockville Pike, Bethesda, MD 20892, United States; 4: David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, MDCC22-442, Los Angeles, CA 90095-1752, United States; 5: Institut Pasteur, 25 Rue du Dr. Roux, Paris 75724, France; 6: University of Virginia School of Medicine, Box 800419, Charlottesville, VA 22902-0419, United States; 7: Vanderbilt Medical Center, 1161 2st Ave. South CCC-5323 MCN, Nashville, TN 37232-2581, United States; 8: National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK; 9: Department of Hygiene and Microbiology, University of Palermo, Via del Vespro 133, Palermo 90127, Italy; 10: Institute fur Hygiene und Labormedizin, Stadt Krankenanstalten, Lutherplatz 40, Krefeld D-47805, Germany; 11: Bureau of Laboratory Sciences, Department of Public Health, 305 South Street Jamaica Plain, MA 02130, United States; 12: Centre for Infectious Diseases and Microbiology (CIDM), Institute of Clinical Pathology and Medical Research (ICPMR), Westmead, NSW 2145, Australia; 13: National Institute of Child Health & Human Development, National Institutes of Health (NIH), MSC 2423, 31 Center Drive, Bethesda, MD 20892-2423, United States; 14: U.K. Medicines and Healthcare Products Regulatory Agency (MHRA), Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK; 15: Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA, United States; 16: Bacterial Vaccine R&D, GlaxoSmithKline Biologicals, Rue de I’Institut 89, Rixensart 1330, Belgium; 17: Sanofi Pasteur, Discovery Drive, Swiftwater, PA 18370, United States; Issue Info: Feb2009, Vol. 27 Issue 6, p803; Thesaurus Term: Epidemiology; Thesaurus Term: World health; Subject Term: Medicine -- Congresses; Subject Term: Immunoassay; Subject Term: Bordetella pertussis; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Whooping cough; Subject: Atlanta (Ga.); Subject: Georgia; Subject: United States; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: Pertussis vaccines; Author-Supplied Keyword: Standardization of serologic assays ; Company/Entity: Centers for Disease Control & Prevention (U.S.) ; Company/Entity: World Health Organization; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 12p; Document Type: Proceeding
L3 - 10.1016/j.vaccine.2008.11.072
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Stansbury, D.
AU - Yeager, C.
AU - Chen, L.
AU - Mueller, C.
AU - Dunn, K. H.
AU - Almaguer, D.
AU - Ernst, J.
AU - Otto, C.
AU - Dang, B.
AU - Gong, F.
T1 - Respiratory and Ocular Symptoms Among Employees of a Hotel Indoor Waterpark Resort -- Ohio, 2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2009/02/06/
VL - 58
IS - 4
M3 - Article
SP - 81
EP - 85
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article focuses on the incidence of 665 reports to the Warren County Combined Health District (WCCHD) of respiratory and eye irritation at a waterpark resort in Ohio from January to March 2007. This included guests and lifeguards. The cause was found to be due to the airborne trichloramine in the waterpark. The National Institute for Occupational Safety and Health (NIOSH) was called by WCCHD to assist in the investigation.
KW - PUBLIC health
KW - WATER parks
KW - GOVERNMENT agencies
KW - OHIO
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 36512834; Stansbury, D. 1 Yeager, C. 1 Chen, L. 2 Mueller, C. 2 Dunn, K. H. 3 Almaguer, D. 3 Ernst, J. 3 Otto, C. 4 Dang, B. 5 Gong, F. 5; Affiliation: 1: Warren County Combined Health District, Ohio 2: Div of Surveillance, Hazard Evaluations, and Field Studies, Warren County Combined Health District, Ohio 3: Div of Applied Research and Technology, National Institute for Occupational Safety and Health, Warren County Combined Health District, Ohio 4: Div of Emergency and Environmental Health Svcs, National Center for Environmental Health, Warren County Combined Health District, Ohio 5: EIS officers, CDC; Source Info: 2/6/2009, Vol. 58 Issue 4, p81; Subject Term: PUBLIC health; Subject Term: WATER parks; Subject Term: GOVERNMENT agencies; Subject Term: OHIO; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; NAICS/Industry Codes: 713110 Amusement and Theme Parks; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wu, John Z.
AU - An, Kai-Nan
AU - Cutlip, Robert G.
AU - Andrew, Michael E.
AU - Dong, Ren G.
T1 - Modeling of the muscle/tendon excursions and moment arms in the thumb using the commercial software anybody
JO - Journal of Biomechanics
JF - Journal of Biomechanics
Y1 - 2009/02/09/
VL - 42
IS - 3
M3 - Article
SP - 383
EP - 388
SN - 00219290
AB - Abstract: A biomechanical model of a thumb would be useful for exploring the mechanical loadings in the musculoskeletal system, which cannot be measured in vivo. The purpose of the current study is to develop a practical kinematic thumb model using the commercial software Anybody (Anybody Technology, Aalborg, Denmark), which includes real CT-scans of the bony sections and realistic tendon/muscle attachments on the bones. The thumb model consists of a trapezium, a metacarpal bone, a proximal and a distal phalanx. These four bony sections are linked via three joints, i.e., IP (interphalangeal), MP (metacarpophalangeal) and CMC (carpometacarpal) joints. Nine muscles were included in the proposed model. The theoretically calculated moment arms of the tendons are compared with the corresponding experimental data by Smutz et al. [1998. Mechanical advantage of the thumb muscles. J. Biomech. 31(6), 565–570]. The predicted muscle moment arms of the majority of the muscle/tendon units agree well with the experimental data in the entire range of motion. Close to the end of the motion range, the predicted moment arms of several muscles (i.e., ADPt and ADPo (transverse and oblique heads of the adductor pollicis, respectively) muscles for CMC abduction/adduction and ADPt and FPB (flexor pollicis brevis) muscle for MP extension/flexion) deviate from the experimental data. The predicted moment potentials for all muscles are consistent with the experimental data. The findings thus suggest that, in a biomechanical model of the thumb, the mechanical functions of muscle–tendon units with small physiological cross-sectional areas (PCSAs) can be well represented using single strings, while those with large PCSAs (flat-wide attachments, e.g., ADPt and ADPo) can be represented by the averaged excursions of two strings. Our results show that the tendons with large PCSAs can be well represented biomechanically using the proposed approach in the major range of motion. [Copyright &y& Elsevier]
AB - Copyright of Journal of Biomechanics is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL models
KW - MUSCLES
KW - TENDONS
KW - BIOMECHANICS
KW - KINEMATICS
KW - COMPUTER software
KW - Kinematics
KW - Moment arm
KW - Muscle–tendon excursion
KW - Simulations
KW - Thumb
N1 - Accession Number: 36340098; Wu, John Z. 1; Email Address: ozw8@cdc.gov An, Kai-Nan 2 Cutlip, Robert G. 1 Andrew, Michael E. 1 Dong, Ren G. 1; Affiliation: 1: National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA 2: Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Source Info: Feb2009, Vol. 42 Issue 3, p383; Subject Term: MATHEMATICAL models; Subject Term: MUSCLES; Subject Term: TENDONS; Subject Term: BIOMECHANICS; Subject Term: KINEMATICS; Subject Term: COMPUTER software; Author-Supplied Keyword: Kinematics; Author-Supplied Keyword: Moment arm; Author-Supplied Keyword: Muscle–tendon excursion; Author-Supplied Keyword: Simulations; Author-Supplied Keyword: Thumb; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jbiomech.2008.11.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jian-Jiang Hao
AU - Yin Liu
AU - Kruhlak, Michael
AU - Debell, Karen E.
AU - Rellahan, Barbara L.
AU - Shaw, Stephen
T1 - Phospholipase C--mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane.
JO - Journal of Cell Biology
JF - Journal of Cell Biology
Y1 - 2009/02/09/
VL - 184
IS - 3
M3 - Article
SP - 451
EP - 462
SN - 00219525
AB - Mechanisms controlling the disassembly of ezrin/ radixin/moesin (ERM) proteins, which link the cytoskeleton to the plasma membrane, are incompletely understood. In lymphocytes, chemokine (e.g., SDF-1) stimulation inactivates ERM proteins, causing their release from the plasma membrane and dephosphorylation. SDF-1-mediated inactivation of ERM proteins is blocked by phospholipase C (PLC) inhibitors. Conversely, reduction of phosphatidylinositol 4,5-bisphosphate (PIP2) levels by activation of PLC, expression of active PLC mutants, or acute targeting of phosphoinositide 5-phosphatase to the plasma membrane promotes release and dephosphorylation of moesin and ezrin. Although expression of phosphomimetic moesin (T558D) or ezrin (T567D) mutants enhances membrane association, activation of PLC still relocalizes them to the cytosol. Similarly, in vitro binding of ERM proteins to the cytoplasmic tail of CD44 is also dependent on PIP2. These results demonstrate a new role of PLCs in rapid cytoskeletal remodeling and an additional key role of PIP2 in ERM protein biology, namely hydrolysis-mediated ERM inactivation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Biology is the property of Rockefeller University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOSPHOLIPASE C
KW - HYDROLYSIS
KW - PHOSPHOINOSITIDES
KW - LYMPHOCYTES
KW - PROTEINS
KW - CYTOSKELETON
KW - CELL membranes
KW - CHEMOKINES
N1 - Accession Number: 36634838; Jian-Jiang Hao 1 Yin Liu 1 Kruhlak, Michael 1 Debell, Karen E. 2 Rellahan, Barbara L. 2 Shaw, Stephen 1; Email Address: shaws@mail.nih.gov; Affiliation: 1: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 2: Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892; Source Info: 2/9/2009, Vol. 184 Issue 3, p451; Subject Term: PHOSPHOLIPASE C; Subject Term: HYDROLYSIS; Subject Term: PHOSPHOINOSITIDES; Subject Term: LYMPHOCYTES; Subject Term: PROTEINS; Subject Term: CYTOSKELETON; Subject Term: CELL membranes; Subject Term: CHEMOKINES; Number of Pages: 12p; Document Type: Article; Full Text Word Count: 8648
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsai, Chao-Ming
AU - Jankowska-Stephens, Ewa
AU - Mizanur, Rahman M.
AU - Cipollo, John F.
T1 - The Fine Structure of Neisseria meningitidis Lipooligosaccharide from the M986 Strain and Three of Its Variants.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/02/13/
VL - 284
IS - 7
M3 - Article
SP - 4616
EP - 4625
SN - 00219258
AB - Neisseria meningitidis is a cause of fatal sepsis and epidemic meningitis. A major virulence factor is cell wall lipooligosaccharide (LOS). The M986 strain has been used extensively in immunological and vaccine research. Yet, the LOS repertoire of this strain is not known. Here we have investigated the LOS structures of M986 and three of its variants OP1, OP2-, and OP2+. This strain and its variants present a series of related LOS families that are increasingly truncated in their listed order. The major structural differences are seen in the lacto-N-neotetraose α-chain. The γ-chain Hep II contains two phosphoethanol- amine (PEA) substitutions at C3 and C6/7. These substitutions were seen in all strains except OP2+ where the canonical core Hep II is missing. The PEA disubstitution was present in nearly stoichiometric amounts with only minor amounts of monosubstitution observed, and no glycomers devoid of PEA were seen. This was also the case in LOS with a complete lacto-N-neotetraosyl α-chain even though previous reports suggested that the presence of an extended α-chain hinders C3 PEA substitution of Hep II. Approximately 50% of γ-chain GlcNAc was present in its 3-OAc-substituted form. Because Hep II C3 PEA substitution and γ-chain GlcNAc OAc addition have been reported to negatively interact, the co-existence of these two modifications in these strains is unique. The LOS structures of M986 and three of its variants have been determined, which better defines these strains as tools for immunological and vaccine research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEISSERIA meningitidis
KW - NEISSERIA
KW - MENINGITIS
KW - PREVENTIVE medicine
KW - SEPTICEMIA
KW - SACCHARIDES
N1 - Accession Number: 37151801; Tsai, Chao-Ming 1 Jankowska-Stephens, Ewa 1 Mizanur, Rahman M. 1 Cipollo, John F. 1; Email Address: john.cipollo@fda.hhs.gov; Affiliation: 1: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 2/13/2009, Vol. 284 Issue 7, p4616; Subject Term: NEISSERIA meningitidis; Subject Term: NEISSERIA; Subject Term: MENINGITIS; Subject Term: PREVENTIVE medicine; Subject Term: SEPTICEMIA; Subject Term: SACCHARIDES; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1074/jbc.M808209200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Hee-Kwon
AU - Chu, Kon
AU - Jung, Keun-Hwa
AU - Lee, Soon-Tae
AU - Bahn, Jae-Joon
AU - Kim, Manho
AU - Lee, Sang Kun
AU - Roh, Jae-Kyu
T1 - Autophagy is involved in the ischemic preconditioning
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2009/02/13/
VL - 451
IS - 1
M3 - Article
SP - 16
EP - 19
SN - 03043940
AB - Abstract: Autophagy is a key pathway for the clearance of damaged organelles. Ischemic preconditioning (IPC) and autophagy are enhanced by mild hypoxic insults, but the association between autophagy and IPC remains unclear. We investigated the existence and role of autophagy in IPC. In an in vitro PC12 cell model, IPC increased generation and degradation of autophagosomes, as revealed by increased LC3-II bands, cathepsin D positive cells, lysosomal activity and autophagic vacuoles on electron microscopy. Autophagic activity was blocked using 3-methyladenine during IPC, and cell viabilities were measured using FASC and WST-1 assays. Inhibition of autophagy, especially during reperfusion or lethal oxygen-glucose deprivation periods ameliorated the neuroprotective effects of IPC. Moreover, inhibiting autophagy also attenuated Hsp70 upregulation induced by IPC. These findings imply that autophagy participates in IPC-induced neuroprotection, and that autophagy might provide a means of neuroprotection against cerebral ischemia. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CEREBRAL ischemia
KW - ANOXEMIA
KW - NEURODEGENERATION
KW - HEAT shock proteins
KW - REPERFUSION (Physiology)
KW - ELECTRON microscopy
KW - 3-methyladenine ( 3MA )
KW - Autophagy
KW - DEVD-Cho ( DEVD )
KW - Hsp70
KW - Ischemic preconditioning
KW - ischemic preconditioning ( IPC )
KW - lethal OGD after preconditioning OGD ( IPC+OGD )
KW - Neuroprotection
KW - oxygen-glucose deprivation ( OGD )
KW - PC12 cell
KW - Wortmannin ( Wort )
N1 - Accession Number: 36195001; Park, Hee-Kwon 1,2 Chu, Kon 1,2 Jung, Keun-Hwa 1,2 Lee, Soon-Tae 1,2,3 Bahn, Jae-Joon 1,2 Kim, Manho 1,2 Lee, Sang Kun 1,2 Roh, Jae-Kyu 1,2; Email Address: rohjk@snu.ac.kr; Affiliation: 1: Stroke & Stem Cell Laboratory, Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea 2: Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul National University, Seoul, South Korea 3: Program in Public Health Service, Seoul National Hospital, Seoul, South Korea; Source Info: Feb2009, Vol. 451 Issue 1, p16; Subject Term: CEREBRAL ischemia; Subject Term: ANOXEMIA; Subject Term: NEURODEGENERATION; Subject Term: HEAT shock proteins; Subject Term: REPERFUSION (Physiology); Subject Term: ELECTRON microscopy; Author-Supplied Keyword: 3-methyladenine ( 3MA ); Author-Supplied Keyword: Autophagy; Author-Supplied Keyword: DEVD-Cho ( DEVD ); Author-Supplied Keyword: Hsp70; Author-Supplied Keyword: Ischemic preconditioning; Author-Supplied Keyword: ischemic preconditioning ( IPC ); Author-Supplied Keyword: lethal OGD after preconditioning OGD ( IPC+OGD ); Author-Supplied Keyword: Neuroprotection; Author-Supplied Keyword: oxygen-glucose deprivation ( OGD ); Author-Supplied Keyword: PC12 cell; Author-Supplied Keyword: Wortmannin ( Wort ); Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neulet.2008.12.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36195001&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105458554
T1 - Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer.
AU - Lin KW
Y1 - 2009/02/15/
N1 - Accession Number: 105458554. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Antiinflammatory Agents, Non-Steroidal -- Therapeutic Use
KW - Aspirin -- Therapeutic Use
KW - Colorectal Neoplasms -- Epidemiology
KW - Colorectal Neoplasms -- Prevention and Control
KW - Asians -- Statistics and Numerical Data
KW - Disease Susceptibility
KW - Incidence
KW - Male
KW - Middle Age
KW - Risk Factors
SP - 325
EP - 326
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 4
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19235500.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105458554&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fan, Xiaohui
AU - Fang, Hong
AU - Hong, Huixiao
AU - Perkins, Roger
AU - Shi, Leming
AU - Tong, Weida
T1 - Correlation analysis of external RNA controls reveals its utility for assessment of microarray assay
JO - Analytical Biochemistry
JF - Analytical Biochemistry
Y1 - 2009/02/15/
VL - 385
IS - 2
M3 - Article
SP - 203
EP - 207
SN - 00032697
AB - Abstract: Quality control of a microarray experiment has become an important issue for both research and regulation. External RNA controls (ERCs), which can be either added to the total RNA level (tERCs) or introduced right before hybridization (cERCs), are designed and recommended by commercial microarray platforms for assessment of performance of a microarray experiment. However, the utility of ERCs has not been fully realized mainly due to the lack of sufficient data resources. The US Food and Drug Administration (FDA)-led community-wide Microarray Quality Control (MAQC) study generates a large amount of microarray data with implementation of ERCs across several commercial microarray platforms. The utility of ERCs in quality control by assessing the ERCs’ concentration–response behavior was investigated in the MAQC study. In this work, an ERC-based correlation analysis was conducted to assess the quality of a microarray experiment. We found that the pairwise correlations of tERCs are sample independent, indicating that the array data obtained from different biological samples can be treated as technical replicates in analysis of tERCs. Consequently, the commonly used quality control method of applying correlation analysis on technical replicates can be adopted for assessing array performance based on different biological samples using tERCs. The proposed approach is sensitive to identifying outlying assays and is not dependent on the choice of normalization method. [Copyright &y& Elsevier]
AB - Copyright of Analytical Biochemistry is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENE expression
KW - CORRELATION (Statistics)
KW - DNA microarrays
KW - OUTLIERS (Statistics)
KW - UNITED States
KW - DNA microarray
KW - External RNA controls
KW - Gene expression
KW - MAQC
KW - Outlier identification
KW - Quality control
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36139609; Fan, Xiaohui 1,2 Fang, Hong 3 Hong, Huixiao 3 Perkins, Roger 3 Shi, Leming 1 Tong, Weida 1; Email Address: weida.tong@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA 2: Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310027, China 3: ICF International, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Feb2009, Vol. 385 Issue 2, p203; Subject Term: GENE expression; Subject Term: CORRELATION (Statistics); Subject Term: DNA microarrays; Subject Term: OUTLIERS (Statistics); Subject Term: UNITED States; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: External RNA controls; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: MAQC; Author-Supplied Keyword: Outlier identification; Author-Supplied Keyword: Quality control; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ab.2008.11.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36139609&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khan, Ashraf A.
AU - Ponce, Elizabeth
AU - Nawaz, M. S.
AU - Chorng-Ming Cheng
AU - Khan, Junaid A.
AU - West, Christine S.
T1 - Identification and Characterization of Class 1 Integron Resistance Gene Cassettes among Salmonella Strains Isolated from Imported Seafood.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/02/15/
VL - 75
IS - 4
M3 - Article
SP - 1192
EP - 1196
SN - 00992240
AB - A total of 210 Salmonella isolates, representing 64 different serovars, were isolated from imported seafood samples, and 55/210 isolates were found to be resistant to at least one antibiotic. Class 1 integrons from three multidrug-resistant Salmonella enterica strains (Salmonella enterica serovars Newport [strain 621, Typhimurium var. Copenhagen [strain 629], and Lansing [strain 8031, originating from Hong Kong, the Philippines, and Taiwan, respectively) were characterized. Southern hybridization of plasmids isolated from these strains, using a class 1 integron probe, showed that trimethoprim-sulfamethoxazole and streptomycin resistance genes were located on a megaplasmid in strain 629. Our study indicates that imported seafood could be a reservoir for Salmonella isolates resistant to multiple antibiotics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - ENTEROBACTERIACEAE
KW - FOOD pathogens
KW - SEAFOOD
KW - ANTIBIOTICS
KW - MICROBIAL metabolites
KW - SALMONELLA enteritidis
KW - PLASMIDS
KW - STREPTOMYCIN
N1 - Accession Number: 36915939; Khan, Ashraf A. 1; Email Address: Ashraf.khan@fda.hhs.gov Ponce, Elizabeth Nawaz, M. S. Chorng-Ming Cheng Khan, Junaid A. 2 West, Christine S.; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research US. Food and Drug Administration, Jefferson, Arkansas 72079 2: Department of Cardiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; Source Info: Feb2009, Vol. 75 Issue 4, p1192; Subject Term: SALMONELLA; Subject Term: ENTEROBACTERIACEAE; Subject Term: FOOD pathogens; Subject Term: SEAFOOD; Subject Term: ANTIBIOTICS; Subject Term: MICROBIAL metabolites; Subject Term: SALMONELLA enteritidis; Subject Term: PLASMIDS; Subject Term: STREPTOMYCIN; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 445220 Fish and Seafood Markets; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1128/AEM.02054-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blachere, Francoise M.
AU - Lindsley, William G.
AU - Pearce, Terri A.
AU - Anderson, Stacey E.
AU - Fisher, Melanie
AU - Khakoo, Rashida
AU - Meade, Barbara J.
AU - Lander, Owen
AU - Davis, Stephen
AU - Thewlis, Robert E.
AU - Celik, Ismail
AU - Chen, Bean T.
AU - Beezhold, Donald H.
T1 - Measurement of Airborne Influenza Virus in a Hospital Emergency Department.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/02/15/
VL - 48
IS - 4
M3 - Article
SP - 438
EP - 440
SN - 10584838
AB - Size-fractionated aerosol particles were collected in a hospital emergency department to test for airborne influenza virus. Using real-time polymerase chain reaction, we confirmed the presence of airborne influenza virus and found that 53% of detectable influenza virus particles were within the respirable aerosol fraction. Our results provide evidence that influenza virus may spread through the airborne route. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Particles
KW - Influenza viruses
KW - Hospital emergency services
KW - Polymerase chain reaction
KW - Respiratory infections
N1 - Accession Number: 36205600; Blachere, Francoise M. 1; Email Address: FBlachere@cdc.gov; Lindsley, William G. 1; Pearce, Terri A. 2; Anderson, Stacey E. 1; Fisher, Melanie 3; Khakoo, Rashida 3; Meade, Barbara J. 1,4; Lander, Owen 5; Davis, Stephen 5; Thewlis, Robert E. 1; Celik, Ismail 6; Chen, Bean T. 1; Beezhold, Donald H. 1; Affiliations: 1: Division of Health Effects Laboratory, West Virginia University, Morgantown, West Virginia; 2: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, West Virginia; 3: Department of Medicine, West Virginia University, Morgantown, West Virginia; 4: Department of Family Medicine, West Virginia University, Morgantown, West Virginia; 5: Department of Emergency Medicine , West Virginia University, Morgantown, West Virginia; 6: Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia, West Virginia; Issue Info: 2/15/2009, Vol. 48 Issue 4, p438; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Particles; Subject Term: Influenza viruses; Subject Term: Hospital emergency services; Subject Term: Polymerase chain reaction; Subject Term: Respiratory infections; Number of Pages: 3p; Document Type: Article
L3 - 10.1086/596478
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36205600&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Antonini, James M.
AU - Roberts, Jenny R.
AU - Stone, Sam
AU - Chen, Bean T.
AU - Schwegler-Berry, Diane
AU - Frazer, David G.
T1 - Short-Term Inhalation Exposure to Mild Steel Welding Fume had no Effect on Lung Inflammation and Injury but did Alter Defense Responses to Bacteria in Rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2009/02/15/
VL - 21
IS - 3
M3 - Article
SP - 182
EP - 192
SN - 08958378
AB - Many workers worldwide are continually exposed to complex aerosols generated from welding processes. The objective was to assess the effect of inhalation exposure to mild steel (MS) welding fume on lung injury, inflammation, and defense responses. Male Sprague-Dawley rats were exposed to MS fume at a concentration of 40 mg/m3 × 3 h/day × 3 or 10 days using a robotic welding fume generator. Controls were exposed to filtered air. To assess lung defense responses, a group of animals were intratracheally inoculated with 5 × 104 Listeria monocytogenes 1 day after the last daily exposure. Welding particles were collected during exposure, and chemical composition and particle size were determined. After exposure, lung injury, inflammation, and host defense (bacterial clearance) were measured. The particles were composed of iron (80.6 %) and manganese (14.7 %) with a mass median aerodynamic diameter of 0.31 μ m. No significant difference was observed in lung injury or inflammation after MS fume inhalation at 1, 4, and 11 days after the last exposure. However, there were significantly more bacteria at 3 days after infection in the lungs of the animals exposed to MS fume compared to air controls. Acute exposure of rats to MS fume had no effect on injury and inflammation, but suppressed lung defense responses after infection. More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Poisonous gases -- Toxicology
KW - Bacteria
KW - Pneumonia
KW - Structural steel -- Welding
KW - Lung diseases
KW - Rats as laboratory animals
N1 - Accession Number: 36353354; Antonini, James M. 1; Email Address: jga6@cdc.gov; Roberts, Jenny R. 1; Stone, Sam 1; Chen, Bean T. 1; Schwegler-Berry, Diane 1; Frazer, David G. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Feb2009, Vol. 21 Issue 3, p182; Thesaurus Term: Poisonous gases -- Toxicology; Thesaurus Term: Bacteria; Subject Term: Pneumonia; Subject Term: Structural steel -- Welding; Subject Term: Lung diseases; Subject Term: Rats as laboratory animals; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 1 Black and White Photograph, 3 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/08958370802360661
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36353354&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schnackenberg, Laura K.
AU - Chen, Minjun
AU - Sun, Jinchun
AU - Holland, Ricky D.
AU - Dragan, Yvonne
AU - Tong, Weida
AU - Welsh, William
AU - Beger, Richard D.
T1 - Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/02/15/
VL - 235
IS - 1
M3 - Article
SP - 25
EP - 32
SN - 0041008X
AB - Abstract: Drug-induced liver injury has been associated with the generation of reactive metabolites, which are primarily detoxified via glutathione conjugation. In this study, it was hypothesized that molecules involved in the synthesis of glutathione would be diminished to replenish the glutathione depleted through conjugation reactions. Since S-adenosylmethionine (SAMe) is the primary source of the sulfur atom in glutathione, UPLC/MS and NMR were used to evaluate metabolites involved with the transulfuration pathway in urine samples collected during studies of eight liver toxic compounds in Sprague-Dawley rats. Urinary levels of creatine were increased on day 1 or day 2 in 8 high dose liver toxicity studies. Taurine concentration in urine was increased in only 3 of 8 liver toxicity studies while SAMe was found to be reduced in 4 of 5 liver toxicity studies. To further validate the results from the metabonomic studies, microarray data from rat liver samples following treatment with acetaminophen was obtained from the Gene Expression Omnibus (GEO) database. Some genes involved in the trans-sulfuration pathway, including guanidinoacetate N-methyltransferase, glycine N-methyltransferase, betaine-homocysteine methyltransferase and cysteine dioxygenase were found to be significantly decreased while methionine adenosyl transferase II, alpha increased at 24 h post-dosing, which is consistent with the SAMe and creatine findings. The metabolic and transcriptomic results show that the trans-sulfuration pathway from SAMe to glutathione was disturbed due to the administration of heptatotoxicants. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATOTOXICOLOGY
KW - LIVER -- Wounds & injuries
KW - METABOLITES
KW - METABOLIC detoxification
KW - GLUTATHIONE
KW - NUCLEAR magnetic resonance
KW - ADENOSYLMETHIONINE
KW - Creatine
KW - Guanidinoacetate N-methyltransferase
KW - Hepatotoxicity
KW - Metabolomics
KW - S-Adenosylmethionine
N1 - Accession Number: 36433839; Schnackenberg, Laura K. 1; Email Address: richard.beger@fda.hhs.gov Chen, Minjun 2 Sun, Jinchun 1 Holland, Ricky D. 1 Dragan, Yvonne 1 Tong, Weida 1 Welsh, William 2 Beger, Richard D. 1; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, FDA, Jefferson, AR 72079, USA 2: Environmental Bioinformatics Computational Toxicology Center, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA; Source Info: Feb2009, Vol. 235 Issue 1, p25; Subject Term: HEPATOTOXICOLOGY; Subject Term: LIVER -- Wounds & injuries; Subject Term: METABOLITES; Subject Term: METABOLIC detoxification; Subject Term: GLUTATHIONE; Subject Term: NUCLEAR magnetic resonance; Subject Term: ADENOSYLMETHIONINE; Author-Supplied Keyword: Creatine; Author-Supplied Keyword: Guanidinoacetate N-methyltransferase; Author-Supplied Keyword: Hepatotoxicity; Author-Supplied Keyword: Metabolomics; Author-Supplied Keyword: S-Adenosylmethionine; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.taap.2008.11.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36433839&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Conway, Patrick H.
AU - Clancy, Carolyn
T1 - Transformation of Health Care at the Front Line.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/02/18/
VL - 301
IS - 7
M3 - Opinion
SP - 763
EP - 765
SN - 00987484
AB - The article discusses a need for health care reform that measures high performance quality and aligns payment to patient outcomes. It describes an approach that includes measurements focusing on the patient, "exception reporting" to decrease the chance of financial penalties and electronic health records to capture data. It discusses the role of health technology in performance measurement and quality assurance and suggests research should provide comparative information for physicians to use.
KW - HEALTH care reform
KW - TOTAL quality management
KW - MEDICINE -- Practice
KW - MEDICAL technology
KW - PHYSICIANS
KW - PATIENTS
KW - HEALTH
KW - MEDICAL economics
KW - ECONOMIC aspects
KW - EDUCATION (Continuing education)
N1 - Accession Number: 36552414; Conway, Patrick H. 1,2,3; Email Address: patrick.conway@hhs.gov Clancy, Carolyn 1,2; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland 2: US Department of Health and Human Services, Washington, DC 3: Center for Health Care Quality and Division of Health Policy and Clinical Effectiveness and Division of General Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Source Info: 2/18/2009, Vol. 301 Issue 7, p763; Subject Term: HEALTH care reform; Subject Term: TOTAL quality management; Subject Term: MEDICINE -- Practice; Subject Term: MEDICAL technology; Subject Term: PHYSICIANS; Subject Term: PATIENTS; Subject Term: HEALTH; Subject Term: MEDICAL economics; Subject Term: ECONOMIC aspects; Subject Term: EDUCATION (Continuing education); NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 621110 Offices of physicians; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); Number of Pages: 3p; Document Type: Opinion
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36552414&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105461091
T1 - Transformation of health care at the front line.
AU - Conway PH
AU - Clancy C
AU - Conway, Patrick H
AU - Clancy, Carolyn
Y1 - 2009/02/18/
N1 - Accession Number: 105461091. Language: English. Entry Date: 20090306. Revision Date: 20161112. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7501160.
KW - Health Care Delivery -- Trends
KW - Health Care Reform -- Standards
KW - Quality Assurance
KW - Health Care Delivery -- Standards
KW - Internship and Residency -- Standards
KW - Medical Informatics
KW - United States
SP - 763
EP - 765
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
JA - JAMA
VL - 301
IS - 7
CY - Chicago, Illinois
PB - American Medical Association
SN - 0098-7484
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA
AD - Agency for Healthcare Research and Quality, Rockville, Maryland, USA. patrick.conway@hhs.gov
U2 - PMID: 19224753.
DO - 10.1001/jama.2009.103
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105461091&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dobrovolsky, Vasily N.
AU - Shaddock, Joseph G.
AU - Mittelstaedt, Roberta A.
AU - Manjanatha, Mugimane G.
AU - Miura, Daishiro
AU - Uchikawa, Makoto
AU - Mattison, Donald R.
AU - Morris, Suzanne M.
T1 - Evaluation of Macaca mulatta as a model for genotoxicity studies
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2009/02/19/
VL - 673
IS - 1
M3 - Article
SP - 21
EP - 28
SN - 13835718
AB - Abstract: We have investigated the use of peripheral blood from the nonhuman primate (NHP) rhesus monkey (Macaca mulatta) as a model system for mutation detection. The rhesus monkey is metabolically closer to humans than most common laboratory animals, and therefore may be a relevant model for hazard identification and human risk assessment. To validate the model, conditions were determined for in vitro selection and expansion of 6-thioguanine-resistant (6-TGr) HPRT mutant and proaerolysin-resistant (ProAERr) PIG-A mutant lymphocytes from peripheral blood obtained by routine venipuncture. Also, flow cytometric methods were developed for the rapid detection of PIG-A mutant erythrocytes. The flow cytometric analysis of PIG-A mutant erythrocytes was based on enumerating cells deficient in surface markers attached to the cellular membrane via glycosylphosphatidyl inositol (GPI) anchors. Mutant cells were enumerated over an extended period of time in peripheral blood of male monkeys receiving daily doses of the electrolyte replenisher Prang™ (a common carrier for oral delivery of drugs in NHPs), and in the blood of one male monkey treated with a single i.p. dose of 50mg/kg of N-ethyl-N-nitrosourea at ∼2 years of age and another similar injection at approximately 3.5 years of age. The spontaneous PIG-A and HPRT T-cell mutant frequency (MF) was low in animals receiving Prang (0–8×10−6), and treatment with ENU resulted in a clearly detectable increase in the frequency of ProAERr and 6-TGr lymphocytes (up to ∼28×10−6 and ∼30×10−6, respectively). Also, the ENU-treated animal had higher frequency of GPI-deficient erythrocytes (46.5×10−6 in the treated animal vs. 7.8±4.2×10−6 in control animals). Our results indicate that the rhesus monkey can be a valuable model for the identification of agents that may impact upon human health as mutagens and that the PIG-A gene can be a useful target for detection of mutation in both white and red blood cells. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Animal models in research
KW - Animal mutation
KW - Rhesus monkey
KW - Flow cytometry
KW - Oral medicine
KW - Erythrocytes
KW - Molecular cloning
KW - Cloning
KW - ENU
KW - HPRT
KW - Lymphocytes
KW - Mutation
KW - PIG-A
N1 - Accession Number: 36377511; Dobrovolsky, Vasily N. 1; Email Address: vasily.dobrovolsky@fda.hhs.gov; Shaddock, Joseph G. 1; Mittelstaedt, Roberta A. 1; Manjanatha, Mugimane G. 1; Miura, Daishiro 1,2; Uchikawa, Makoto 3; Mattison, Donald R. 4; Morris, Suzanne M. 1; Affiliations: 1: US FDA, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Rd., HFT-120, Jefferson, AR 72079, USA; 2: Teijin Pharma Ltd., Tokyo, Japan; 3: Japanese Red Cross, Tokyo Blood Center, Tokyo, Japan; 4: US NIH, NICHD, Bethesda, MD 20852, USA; Issue Info: Feb2009, Vol. 673 Issue 1, p21; Thesaurus Term: Genetic toxicology; Thesaurus Term: Animal models in research; Thesaurus Term: Animal mutation; Subject Term: Rhesus monkey; Subject Term: Flow cytometry; Subject Term: Oral medicine; Subject Term: Erythrocytes; Subject Term: Molecular cloning; Author-Supplied Keyword: Cloning; Author-Supplied Keyword: ENU; Author-Supplied Keyword: HPRT; Author-Supplied Keyword: Lymphocytes; Author-Supplied Keyword: Mutation; Author-Supplied Keyword: PIG-A; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrgentox.2008.11.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36377511&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Morris, Suzanne M.
AU - Dobrovolsky, Vasily N.
AU - Shaddock, Joseph G.
AU - Mittelstaedt, Roberta A.
AU - Bishop, Michelle E.
AU - Manjanatha, Mugimane G.
AU - Shelton, Sharon D.
AU - Doerge, Daniel R.
AU - Twaddle, Nathan C.
AU - Chen, James J.
AU - Lin, Chien-Ju
AU - Paule, Merle G.
AU - Slikker, William
AU - Hotchkiss, Charlotte E.
AU - Petibone, Dayton
AU - Tucker, James D.
AU - Mattison, Donald R.
T1 - The genetic toxicology of methylphenidate hydrochloride in non-human primates
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2009/02/19/
VL - 673
IS - 1
M3 - Article
SP - 59
EP - 66
SN - 13835718
AB - Abstract: The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a long-term, chronic dosing regimen. Thus, approximately two-year old, male rhesus monkeys of Indian origin were orally exposed to MPH diluted in the electrolyte replenisher, Prang®, five days per week over a 20-month period. There were 10 animals per dose group and the doses were (1) control, Prang only, (2) low, 0.15mg/kg of MPH twice per day increased to 2.5mg/kg twice per day and (3) high, 1.5mg/kg of MPH twice per day increased to 12.5mg/kg twice per day. Blood samples were obtained from each animal to determine the base-line serum levels of MPH and the major metabolite of MPH in NHP, ritalinic acid (RA). In addition, the base-line frequency of micronucleated erythrocytes (MN-RETs) by flow cytometry, HPRT mutants by a lymphocyte cloning assay, and chromosome aberrations by FISH painting were determined from peripheral blood samples. Once dosing began, the serum levels of MPH and its major metabolite, RA, were determined monthly. The MN-RET frequency and health parameters (CBC, serum chemistries) were also determined monthly. HPRT mutant and chromosome aberration frequencies were measured every three months. CBC values and serum chemistries, with the exception of alanine amino transferase, were within normal limits over the course of drug exposure. The final plasma levels of MPH were similar to those produced by the pediatric dose of 0.3μg/ml. No significant increases in the frequencies of MN-RETs, HPRT mutants, or chromosome aberrations were detected in the treated animals compared to the control animals over the 20-month exposure period. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Animal mutation
KW - Metabolites
KW - Methylphenidate
KW - Primates as laboratory animals
KW - Serum
KW - Electrolytes
KW - Flow cytometry
KW - Chromosome aberrations
KW - HPRT mutations
KW - Micronuclei
KW - Non-human primates
N1 - Accession Number: 36377516; Morris, Suzanne M. 1; Email Address: suzanne.morris@fda.hhs.gov; Dobrovolsky, Vasily N. 1; Shaddock, Joseph G. 1; Mittelstaedt, Roberta A. 1; Bishop, Michelle E. 1; Manjanatha, Mugimane G. 1; Shelton, Sharon D. 1; Doerge, Daniel R. 2; Twaddle, Nathan C. 2; Chen, James J. 3; Lin, Chien-Ju 3; Paule, Merle G. 4; Slikker, William 5; Hotchkiss, Charlotte E. 6; Petibone, Dayton 7; Tucker, James D. 7; Mattison, Donald R. 8; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States; 3: Division of Personalized Medicine and Nutrition, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States; 4: Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States; 5: Office of the Director, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States; 6: Washington National Primate Research Center, Seattle, WA, United States; 7: Department of Biological Sciences, Wayne State University, Detroit, MI, United States; 8: Eunice Kennedy Shriver National Center for Child Health and Development, Bethesda, MD, United States; Issue Info: Feb2009, Vol. 673 Issue 1, p59; Thesaurus Term: Genetic toxicology; Thesaurus Term: Animal mutation; Thesaurus Term: Metabolites; Subject Term: Methylphenidate; Subject Term: Primates as laboratory animals; Subject Term: Serum; Subject Term: Electrolytes; Subject Term: Flow cytometry; Author-Supplied Keyword: Chromosome aberrations; Author-Supplied Keyword: HPRT mutations; Author-Supplied Keyword: Micronuclei; Author-Supplied Keyword: Non-human primates; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.mrgentox.2008.12.001
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105455803
T1 - Pharmacogenetics -- tailoring treatment for the outliers.
AU - Woodcock J
AU - Lesko LJ
Y1 - 2009/02/19/
N1 - Accession Number: 105455803. Language: English. Entry Date: 20090313. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Anticoagulants -- Administration and Dosage
KW - Pharmacogenetics
KW - Warfarin -- Administration and Dosage
KW - 6-Mercaptopurine -- Administration and Dosage
KW - 6-Mercaptopurine -- Adverse Effects
KW - International Normalized Ratio
KW - Transferases
KW - Transferases -- Deficiency
SP - 811
EP - 813
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 360
IS - 8
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - From the Center for Drug Evaluation and Research, Food and Drug Administration, White Oak, MD.
U2 - PMID: 19228625.
DO - 10.1056/NEJMe0810630
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105455803&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yamada, Atsushi
AU - Suzuki, Dai
AU - Miyazono, Agasa
AU - Oshima, Kumiko
AU - Kamiya, Akihide
AU - Zhao, Baohong
AU - Takami, Masamichi
AU - Donnelly, Raymond P.
AU - Itabe, Hiroyuki
AU - Yamamoto, Matsuo
AU - Kimura, Shioko
AU - Kamijo, Ryutaro
T1 - IFN-γ down-regulates Secretoglobin 3A1 gene expression
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2009/02/20/
VL - 379
IS - 4
M3 - Article
SP - 964
EP - 968
SN - 0006291X
AB - Abstract: STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-γ on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-γ in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-γ induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INTERFERONS
KW - GENETIC regulation
KW - INFLAMMATION
KW - EPITHELIAL cells
KW - CELL differentiation
KW - PROMOTERS (Genetics)
KW - GENETIC aspects
KW - IFN-γ
KW - SCGB3A1
KW - Uteroglobin-related protein 2
N1 - Accession Number: 36433910; Yamada, Atsushi 1,2; Email Address: yamadaa@dent.showa-u.ac.jp Suzuki, Dai 1 Miyazono, Agasa 1,3 Oshima, Kumiko 4 Kamiya, Akihide 5 Zhao, Baohong 1 Takami, Masamichi 1 Donnelly, Raymond P. 6 Itabe, Hiroyuki 4 Yamamoto, Matsuo 3 Kimura, Shioko 2 Kamijo, Ryutaro 1; Affiliation: 1: Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan 2: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 3: Department of Periodontology, School of Dentistry, Showa University, Ohta, Tokyo 145-8515, Japan 4: Department of Biological Chemistry, School of Pharmacy, Showa University, Shinagawa, Tokyo 142-8555, Japan 5: Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Minato, Tokyo 108-8639, Japan 6: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Feb2009, Vol. 379 Issue 4, p964; Subject Term: INTERFERONS; Subject Term: GENETIC regulation; Subject Term: INFLAMMATION; Subject Term: EPITHELIAL cells; Subject Term: CELL differentiation; Subject Term: PROMOTERS (Genetics); Subject Term: GENETIC aspects; Author-Supplied Keyword: IFN-γ; Author-Supplied Keyword: SCGB3A1; Author-Supplied Keyword: Uteroglobin-related protein 2; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.bbrc.2008.12.187
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36433910&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thornton, Mark
T1 - The Next Front in the War on Cancer.
JO - Wall Street Journal - Eastern Edition
JF - Wall Street Journal - Eastern Edition
Y1 - 2009/02/27/
VL - 253
IS - 47
M3 - Opinion
SP - A17
SN - 00999660
AB - The author questions the ability of the National Cancer Institute (NCI) to effectively use the $10 billion funding from the U.S. economic stimulus package of President Barack Obama to advance cancer treatment. He predicts that NCI will distribute the money to cancer research community. A leader of a march that demanded more funding for cancer research in 1999 said that there were no meaningful accomplishments from the funding. He stresses the importance of fast clinical trials of cancer treatment.
KW - FEDERAL aid to research
KW - CANCER research
KW - CANCER treatment
KW - UNITED States
KW - NATIONAL Cancer Institute (U.S.)
KW - UNITED States. American Recovery & Reinvestment Act of 2009
N1 - Accession Number: 36965509; Thornton, Mark 1,2,3; Affiliation: 1: Medical Officer, Food and Drug Administration 2: President of the Sarcoma Foundation of America 3: Biotechnology Industry; Source Info: 2/27/2009, Vol. 253 Issue 47, pA17; Subject Term: FEDERAL aid to research; Subject Term: CANCER research; Subject Term: CANCER treatment; Subject Term: UNITED States; Company/Entity: NATIONAL Cancer Institute (U.S.); Reviews & Products: UNITED States. American Recovery & Reinvestment Act of 2009; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 0p; Illustrations: 1 Black and White Photograph; Document Type: Opinion
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ku, Bon Ki
AU - Fernandez de la Mora, Juan
T1 - Relation between Electrical Mobility, Mass, and Size for Nanodrops 1-6.5 nm in Diameter in Air.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2009/03//
VL - 43
IS - 3
M3 - Article
SP - 241
EP - 249
SN - 02786826
AB - A large number of data on mobility and mass have been newly obtained or reanalyzed for clusters of a diversity of materials, with the aim of determining the relation between electrical mobility (Z) and mass diameter dm = (6m/πρ)1/3 (m is the particle mass and ρ the bulk density of the material forming the cluster) for nanoparticles with dm ranging from 1 nm to 6.5 nm. The clusters were generated by electrospraying solutions of ionic liquids, tetra-alkyl ammonium salts, cyclodextrin, bradykinin, etc., in acetonitrile, ethanol, water, or formamide. Their electrical mobilities Z in air were measured directly by a differential mobility analyzer (DMA) of high resolution. Their masses m were determined either directly via mass spectrometry, or assigned indirectly by first distinguishing singly (z = 1) and doubly (z = 2) charged clusters, and then identifying monomers, dimers, . . . n-mers, etc., from their ordering in the mobility spectrum. Provided that dm > 1.3 nm, data of the form dm vs. [z(1+mg/m)1/2/Z)]1/2 fall in a single curve for nanodrops of ionic liquids (ILs) for which ρ is known (mg is the mass of the molecules of suspending gas). Using an effective particle diameter dp = dm + dg and a gas molecule diameter dg = 0.300 nm, this curve is also in excellent agreement with the Stokes-Millikan law for spheres. Particles of solid materials fit similarly well the same Stokes-Millikan law when their (unknown) bulk density is assigned appropriately. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NANOPARTICLES
KW - MASS (Physics)
KW - PARTICLES
KW - RESEARCH
KW - IONIC liquids
KW - PARTICLE size determination
N1 - Accession Number: 52776460; Ku, Bon Ki 1 Fernandez de la Mora, Juan 2; Email Address: juan.delamora@yale.edu; Affiliation: 1: Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA 2: Yale University, Mechanical Engineering Department, New Haven, Connecticut, USA; Source Info: Mar2009, Vol. 43 Issue 3, p241; Subject Term: NANOPARTICLES; Subject Term: MASS (Physics); Subject Term: PARTICLES; Subject Term: RESEARCH; Subject Term: IONIC liquids; Subject Term: PARTICLE size determination; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/02786820802590510
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=52776460&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105479156
T1 - CMS's Hospital-Acquired Condition Lists Link Hospital Payment, Patient Safety.
AU - Clancy CM
Y1 - 2009/03//Mar/Apr2009
N1 - Accession Number: 105479156. Language: English. Entry Date: 20090605. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Health Facility Administration
KW - Insurance, Health, Reimbursement
KW - Quality of Health Care -- Administration
KW - Safety
KW - United States Centers for Medicare and Medicaid Services -- Administration
KW - Catheter-Related Infections -- Epidemiology
KW - Catheter-Related Infections -- Prevention and Control
KW - Health Policy
KW - Quality of Health Care -- Economics
KW - United States Centers for Medicare and Medicaid Services -- Economics
KW - United States
SP - 166
EP - 168
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 24
IS - 2
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 19228892.
DO - 10.1177/1062860608331241
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105479156&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Colpe, Lisa J.
AU - Epstein, Joan F.
AU - Barker, Peggy R.
AU - Gfroerer, Joseph C.
T1 - Screening for Serious Mental Illness in the National Survey on Drug Use and Health (NSDUH)
JO - Annals of Epidemiology
JF - Annals of Epidemiology
Y1 - 2009/03//
VL - 19
IS - 3
M3 - Article
SP - 210
EP - 211
SN - 10472797
KW - Alcohol
KW - Alcohol, Drug Abuse, and Mental Health Administration ( ADAMHA )
KW - and Mental Health Administration ( ADAMHA )
KW - Drug Abuse
KW - K6 nonspecific psychological distress scale ( K6 )
KW - major depressive episode ( MDE )
KW - National Comorbidity Survey–Replication ( NCS-R )
KW - National Survey on Drug Use and Health ( NSDUH )
KW - serious mental illness ( SMI )
KW - Substance Abuse and Mental Health Services Administration ( SAMHSA )
N1 - Accession Number: 36477639; Colpe, Lisa J. 1; Email Address: Lisa.Colpe@SAMHSA.hhs.gov Epstein, Joan F. 2 Barker, Peggy R. 1 Gfroerer, Joseph C. 1; Affiliation: 1: Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD 2: Chronic Disease Surveillance and Research Branch, California Department of Public Health, Sacramento, CA; Source Info: Mar2009, Vol. 19 Issue 3, p210; Author-Supplied Keyword: Alcohol; Author-Supplied Keyword: Alcohol, Drug Abuse, and Mental Health Administration ( ADAMHA ); Author-Supplied Keyword: and Mental Health Administration ( ADAMHA ); Author-Supplied Keyword: Drug Abuse; Author-Supplied Keyword: K6 nonspecific psychological distress scale ( K6 ); Author-Supplied Keyword: major depressive episode ( MDE ); Author-Supplied Keyword: National Comorbidity Survey–Replication ( NCS-R ); Author-Supplied Keyword: National Survey on Drug Use and Health ( NSDUH ); Author-Supplied Keyword: serious mental illness ( SMI ); Author-Supplied Keyword: Substance Abuse and Mental Health Services Administration ( SAMHSA ); Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.annepidem.2008.09.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105453372
T1 - Screening for serious mental illness in the National Survey on Drug Use and Health (NSDUH)
AU - Colpe LJ
AU - Epstein JF
AU - Barker PR
AU - Gfroerer JC
Y1 - 2009/03//
N1 - Accession Number: 105453372. Language: English. Entry Date: 20090515. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9100013.
KW - Community Mental Health Services -- Methods
KW - Mental Disorders -- Diagnosis
KW - Substance Use Disorders -- Psychosocial Factors
KW - Activities of Daily Living
KW - Adolescence
KW - Adult
KW - Community Mental Health Services -- Administration
KW - Diagnosis, Psychosocial
KW - Female
KW - Health Screening -- Methods
KW - Male
KW - Mental Disorders -- Epidemiology
KW - Mental Disorders -- Psychosocial Factors
KW - Middle Age
KW - Reproducibility of Results
KW - Substance Use Disorders -- Epidemiology
KW - United States
KW - Human
SP - 210
EP - 211
JO - Annals of Epidemiology
JF - Annals of Epidemiology
JA - ANN EPIDEMIOL
VL - 19
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1047-2797
AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA. Lisa.Colpe@SAMHSA.hhs.gov
U2 - PMID: 19217004.
DO - 10.1016/j.annepidem.2008.09.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105453372&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105468649
T1 - Comparison of nanoparticle filtration performance of NIOSH-approved and CE-marked particulate filtering facepiece respirators.
AU - Rengasamy S
AU - Eimer BC
AU - Shaffer RE
Y1 - 2009/03//
N1 - Accession Number: 105468649. Language: English. Entry Date: 20090515. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Occupational Health
KW - Respiratory Protective Devices -- Standards
KW - Aerosols
KW - Air Pollutants, Occupational
KW - Equipment Design
KW - Europe
KW - Filtration -- Equipment and Supplies
KW - Nanotechnology
KW - National Institute for Occupational Safety and Health -- Standards
KW - Silver
KW - United States
KW - Human
SP - 117
EP - 128
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 2
PB - Oxford University Press / USA
SN - 0003-4878
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA 15236, USA. arengasamy@cdc.gov
U2 - PMID: 19261695.
DO - annhyg/men086
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105468649&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105475578
T1 - Steam sterilization and internal count sheets: assessing the potential for cytotoxicity.
AU - Lucas AD
AU - Chobin N
AU - Conner R
AU - Gordon EA
AU - Mitchell S
AU - Perry B
AU - Stratmeyer ME
Y1 - 2009/03//
N1 - Accession Number: 105475578. Language: English. Entry Date: 20090522. Revision Date: 20150818. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0372403.
KW - Sterilization and Disinfection -- Adverse Effects
KW - Sterilization and Disinfection -- Methods
KW - Surgical Count Procedure -- Equipment and Supplies
KW - Surgical Equipment and Supplies
KW - Biological Assay
KW - Toxicity Tests
KW - Human
SP - 521
EP - 531
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 89
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Count sheets, when placed in contact with surgical instruments during steam sterilization, can transfer ink to the instruments. To explore whether this poses a safety concern, stainless steel instruments were placed on top of completely inked paper and subjected to steam sterilization, extracted, and tested for cytotoxicity. Preprinted labels were examined in a similar fashion. Extracts from stainless steel devices exposed to ink, toner, or labels showed no significant cytotoxic response, although the ink residue on the devices after steam sterilization is difficult to remove and detrimental to the instrument. Placing a barrier between the count sheet and the devices facilitates reuse of the instruments. AORN J 89 (March 2009) 521-531. (c) AORN, Inc, 2009.
SN - 0001-2092
AD - Chemist, US Food and Drug Administration Center for Device and Radiological Health OSEL/DB, Silver Spring, MD
U2 - PMID: 19269377.
DO - 10.1016/j.aorn.2008.09.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105475578&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yuan Gao
AU - Holland, Ricky D.
AU - Li-Rong Yu
T1 - Quantitative proteomics for drug toxicity.
JO - Briefings in Functional Genomics & Proteomics
JF - Briefings in Functional Genomics & Proteomics
Y1 - 2009/03//
VL - 8
IS - 2
M3 - Article
SP - 158
EP - 166
SN - 14739550
AB - The emerging field of toxicoproteomics has been greatly advanced by quantitative proteomic technologies and their increasing applications in toxicology. The discipline is focused on the proteomic study of toxicity caused by toxic substances, including but not limited to drugs, toxins, environmental stressors, chemicals and any other materials that induce significant pathological responses. Drug safety is a major point of concern during the development phase and clinical application. Identification of toxicity biomarkers, potential drug targets and characterization of toxicity mechanisms represent major research areas for quantitative toxicoproteomics during drug development and evaluation. Further development and application of quantitative proteomic approaches would significantly facilitate the realization of personalized medicine. [ABSTRACT FROM AUTHOR]
AB - Copyright of Briefings in Functional Genomics & Proteomics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - TOXICOLOGY
KW - TOXIC substance exposure
KW - DRUGS -- Toxicology
KW - DRUG development
KW - drug target
KW - mass spectrometry
KW - proteomics
KW - toxicity biomarker
KW - toxicity mechanism
KW - toxicoproteomics
N1 - Accession Number: 51666680; Yuan Gao 1 Holland, Ricky D. 2 Li-Rong Yu 3; Email Address: lirong.yu@fda.hhs.gov; Affiliation: 1: Post-doctoral fellow in the Center for Proteomics, Division of Systems Toxicology, National Center for Toxicological Research of U.S. Food and Drug Administration (FDA). 2: Research chemist in the Center for Proteomics, Division of Systems Toxicology, National Center for Toxicological Research of U.S. Food and Drug Administration (FDA). 3: Director of the Center for Proteomics, Division of Systems Toxicology, National Center for Toxicological Research of U.S. Food and Drug Administration (FDA).; Source Info: Mar2009, Vol. 8 Issue 2, p158; Subject Term: PROTEOMICS; Subject Term: TOXICOLOGY; Subject Term: TOXIC substance exposure; Subject Term: DRUGS -- Toxicology; Subject Term: DRUG development; Author-Supplied Keyword: drug target; Author-Supplied Keyword: mass spectrometry; Author-Supplied Keyword: proteomics; Author-Supplied Keyword: toxicity biomarker; Author-Supplied Keyword: toxicity mechanism; Author-Supplied Keyword: toxicoproteomics; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Illustrations: 2 Diagrams; Document Type: Article
L3 - 10.1093/bfgp/elp006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=51666680&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mansoer, John
AU - Scheele, Suzanne
AU - Floyd, Katherine
AU - Dye, Christopher
AU - Sitienei, Joseph
AU - Williams, Brian
T1 - New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2009/03//
VL - 87
IS - 3
M3 - Article
SP - 186
EP - B
PB - World Health Organization
SN - 00429686
AB - Objective To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent. Methods We estimated the smear-positive tuberculosis CDR in HIV-negative and HIV-positive adults, and in all adults in Kenya. Data on time trends in tuberculosis case notification rates and on HIV infection prevalence in adults and in tuberculosis patients were used, along with data on tuberculosis control programme performance. Findings In 2006, the estimated smear-positive tuberculosis CDR in HIV-negative adults was 79% (95% confidence interval, CI: 64--94) and in HIV-positive adults, 57% (95% CI: 26--88), giving a weighted mean of 68% (95% CI: 49--87). The separate estimate for all smear-positive tuberculosis cases was 72% (95% CI: 53--91), giving an overall average for the three estimates of 70% (95% CI: 58--82). As the tuberculosis CDR in 1996 was 57% (95% CI: 47--67), the estimated increase by 2006 was 13 percentage points (95% CI: 6--20), or 23%. This increase was accompanied by a more than doubling of the resources devoted to tuberculosis control in Kenya, including facilities and staff. Conclusion Using three approaches to estimate the tuberculosis CDR in a country where HIV infection is prevalent, we showed that expansion of the tuberculosis control programme in Kenya led to an increase of 23% in the CDR between 1996 and 2006. While the methods developed here can be applied in other countries with a high prevalence of HIV infection, they rely on precise data on trends in such prevalence in the general population and among tuberculosis patients. (English) [ABSTRACT FROM AUTHOR]
AB - Objetivo Desarrollar nuevos métodos para estimar la tasa de detección de casos (TDC) de tuberculosis con frotis de esputo positivo en un país con alta prevalencia de infección por VIH. Métodos Estimamos la TDC de tuberculosis bacilífera en adultos VIH-negativos y VIH-positivos, así como en todos los adultos de Kenya. Se utilizaron datos sobre las tendencias temporales de las tasas de notificación de casos de tuberculosis y sobre la prevalencia de la infección por VIH en los adultos y en los pacientes con tuberculosis, junto con datos sobre la eficacia del programa de lucha antituberculosa. Resultados En 2006, la TDC estimada de tuberculosis bacilífera fue del 79% (intervalo de confianza, IC, del 95%: 64--94) para los adultos VIH-negativos, y del 57% para los VIH-positivos, (IC95%: 26--88), lo que arroja una media ponderada del 68% (IC95%: 49--87). La estimación correspondiente a todos los casos bacilíferos de tuberculosis fue del 72% (IC95%: 53--91), lo que arroja una media global para las tres estimaciones del 70% (IC95%: 58--82). Dado que la TDC de tuberculosis en 1996 fue del 57% (IC95%: 47--67), el aumento estimado para 2006 es de 13 puntos porcentuales (IC95%: 6--20), lo que supone un incremento del 23%. Este aumento se asoció a una más que duplicación de los recursos dedicados al control de la tuberculosis en Kenya, incluidos trabajadores e instalaciones. Conclusión Estimando de tres formas distintas la TDC en un país con alta prevalencia de infección por VIH, mostramos que la expansión del programa de lucha antituberculosa en Kenya condujo a un aumento del 23% de la TDC entre 1996 y 2006. Aunque pueden aplicarse en otros países con alta prevalencia de VIH, los métodos aquí desarrollados exigen datos precisos sobre las tendencias de esa prevalencia en la población general y entre los enfermos de tuberculosis. (Spanish) [ABSTRACT FROM AUTHOR]
AB - Objectif Mettre au point de nouvelles méthodes pour estimer le taux de dépistage de la tuberculose à frottis positifs dans les pays de forte prévalence des infections à VIH. Méthodes Nous avons estimé ce taux chez les adultes positifs et négatifs pour le VIH et chez l'ensemble des adultes au Kenya. Nous avons utilisé des données de tendance dans le temps des taux de notification de la tuberculose et des données de prévalence de l'infection à VIH chez les adultes et les individus tuberculeux, ainsi que des informations sur les performances du programme de lutte antituberculeuse. Résultats En 2006, le taux de dépistage des cas de tuberculose à frottis positifs chez les adultes négatifs pour le VIH était estimé à 79 % (intervalle de confiance à 95 %, IC : 64-94) et chez les adultes positifs pour ce virus à 57 % (IC à 95 % : 26-88), ce qui donnait une moyenne pondérée de 68 % (IC à 95 %49-87). En estimant séparément le taux de dépistage pour l'ensemble des cas de tuberculose à frottis positifs, on obtenait une valeur de 72 % (IC à 95 % : 53-91), d'oú une moyenne globale pour les trois estimations de 70 % (IC à 95 % : 58-82). Le taux de dépistage de la tuberculose en 1996 étant de 57 % (IC à 95 %47-67), l'augmentation entre 1996 et 2006 a été estimée à 13 points de pourcentage (IC à 95 %6-20), soit 23 %. En parallèle à cet accroissement, le montant des ressources consacrées à la lutte antituberculeuse au Kenya, y compris les installations et le personnel, a plus que doublé. Conclusion En utilisant trois approches pour estimer le taux de dépistage de la tuberculose dans un pays de forte prévalence du VIH, nous avons montré que l'expansion du programme de lutte antituberculeuse kenyan avait entraîné une augmentation de 23 % du taux de dépistage de la tuberculose entre 1996 et 2006. Bien que les méthodes mises au point puissent être appliquées dans d'autres pays de forte prévalence des infections à VIH, cette application doit s'appuyer sur des données précises concernant les tendances de la prévalence de ces infections parmi la population générale et les individus tuberculeux. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIAL diseases
KW - RESEARCH
KW - TUBERCULOSIS -- Prevention
KW - LUNG diseases -- Diagnosis
KW - CLINICAL pathology
KW - HIV-positive persons
KW - KENYA
N1 - Accession Number: 36922664; Mansoer, John 1 Scheele, Suzanne 2 Floyd, Katherine 2 Dye, Christopher 2 Sitienei, Joseph 3 Williams, Brian 2; Email Address: williamsbg@who.int; Affiliation: 1: US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya. 2: Stop TB Department, World Health Organization, 20 avenue Appia, 1211 Geneva 27, Switzerland. 3: National Leprosy and Tuberculosis Control Programme, Nairobi, Kenya.; Source Info: Mar2009, Vol. 87 Issue 3, p186; Subject Term: MYCOBACTERIAL diseases; Subject Term: RESEARCH; Subject Term: TUBERCULOSIS -- Prevention; Subject Term: LUNG diseases -- Diagnosis; Subject Term: CLINICAL pathology; Subject Term: HIV-positive persons; Subject Term: KENYA; Number of Pages: 9p; Illustrations: 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105483478
T1 - New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya.
AU - Mansoer J
AU - Scheele S
AU - Floyd K
AU - Dye C
AU - Sitienei J
AU - Williams B
Y1 - 2009/03//
N1 - Accession Number: 105483478. Language: English. Entry Date: 20090501. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed; Public Health. Special Interest: Public Health. Grant Information: Gates Foundation. NLM UID: 7507052.
KW - HIV Infections -- Epidemiology -- Kenya
KW - Tuberculin Test -- Trends
KW - Tuberculosis, Pulmonary -- Epidemiology -- Kenya
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Funding Source
KW - HIV Infections -- Risk Factors
KW - Kenya
KW - Odds Ratio
KW - Human
SP - 186
EP - B
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
JA - BULL WORLD HEALTH ORGAN
VL - 87
IS - 3
PB - World Health Organization
AB - Objective To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent. Methods We estimated the smear-positive tuberculosis CDR in HIV-negative and HIV-positive adults, and in all adults in Kenya. Data on time trends in tuberculosis case notification rates and on HIV infection prevalence in adults and in tuberculosis patients were used, along with data on tuberculosis control programme performance. Findings In 2006, the estimated smear-positive tuberculosis CDR in HIV-negative adults was 79% (95% confidence interval, CI: 64--94) and in HIV-positive adults, 57% (95% CI: 26--88), giving a weighted mean of 68% (95% CI: 49--87). The separate estimate for all smear-positive tuberculosis cases was 72% (95% CI: 53--91), giving an overall average for the three estimates of 70% (95% CI: 58--82). As the tuberculosis CDR in 1996 was 57% (95% CI: 47--67), the estimated increase by 2006 was 13 percentage points (95% CI: 6--20), or 23%. This increase was accompanied by a more than doubling of the resources devoted to tuberculosis control in Kenya, including facilities and staff. Conclusion Using three approaches to estimate the tuberculosis CDR in a country where HIV infection is prevalent, we showed that expansion of the tuberculosis control programme in Kenya led to an increase of 23% in the CDR between 1996 and 2006. While the methods developed here can be applied in other countries with a high prevalence of HIV infection, they rely on precise data on trends in such prevalence in the general population and among tuberculosis patients. Copyright © 2009 World Health Organization
SN - 0042-9686
AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya.
U2 - PMID: 19377714.
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DP - EBSCOhost
DB - rzh
ER -
TY - NEWS
AU - Hinton, David E.
AU - Hardman, Ron C.
AU - Kullman, Seth W.
AU - Law, Jerry M. (Mac)
AU - Schmale, Michael C.
AU - Walter, Ronald B.
AU - Winn, Richard N.
AU - Yoder, Jeffrey A.
T1 - Aquatic animal models of human disease: Selected papers and recommendations from the 4th Conference
JO - Comparative Biochemistry & Physiology Part C: Toxicology & Pharmacology
JF - Comparative Biochemistry & Physiology Part C: Toxicology & Pharmacology
Y1 - 2009/03//
VL - 149
IS - 2
M3 - Editorial
SP - 121
EP - 128
SN - 15320456
N1 - Accession Number: 36565756; Hinton, David E. 1; Email Address: dhinton@duke.edu Hardman, Ron C. 2; Email Address: ron.hardman@duke.edu Kullman, Seth W. 3; Email Address: sethwkullma@ncsu.edu Law, Jerry M. (Mac) 4; Email Address: mac_law@ncsu.edu Schmale, Michael C. 5; Email Address: mschmale@rsmas.miami.edu Walter, Ronald B. 6; Email Address: rwalter@txstate.edu Winn, Richard N. 7; Email Address: rwinn@uga.edu Yoder, Jeffrey A. 8; Email Address: jeff_yoder@ncsu.edu; Affiliation: 1: Division of Environmental Sciences and Policy, Nicholas School of the Environment, Duke University, Box 90328, A333B LSRC, Durham, NC 27708-0328, USA 2: U.S. Food and Drug Administration, CPK2 RM3066 HFS-246 5100 Paint Branch Parkway College Park, MD 20740, USA 3: Department of Environmental and Molecular Toxicology, Box 7633, North Carolina State University, Raleigh, NC 27695-7633, USA 4: Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA 5: Division of Marine Biology and Fisheries, Rosentiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Cswy., Miami, FL 33149, USA 6: Molecular Biosciences Research Group, Department of Chemistry and Biochemistry, 419 Centennial Hall, Texas State University, 601 University Drive, San Marcos, TX 78666, USA 7: Aquatic Biotechnology and Environmental Lab (ABEL), 2580 Devil's Ford Road, Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602, USA 8: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA; Source Info: Mar2009, Vol. 149 Issue 2, p121; Number of Pages: 8p; Document Type: Editorial
L3 - 10.1016/j.cbpc.2008.12.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Özgen Karacan, C.
T1 - Degasification system selection for US longwall mines using an expert classification system
JO - Computers & Geosciences
JF - Computers & Geosciences
Y1 - 2009/03//
VL - 35
IS - 3
M3 - Article
SP - 515
EP - 526
SN - 00983004
AB - Abstract: Methane emissions from the active face areas and from the fractured formations overlying the mined coalbed can affect safety and productivity in longwall mines. Since ventilation alone may not be sufficient to control the methane levels on a longwall operation, gob vent boreholes (GVB), horizontal and vertical drainage boreholes, and their combinations are drilled and used as supplementary methane control measures in many mines. However, in most cases, the types of degasification wellbores chosen are decided based on previous experiences without analyzing the different factors that may affect this decision. This study describes the development of an expert classification system used as a decision tool. It was built using a multilayer perceptron (MLP) type artificial neural network (ANN) structure. The ANN was trained using different geographical locations, longwall operation parameters, and coalbed characteristics as input and was tested to classify the output into four different selections, which are actual degasification designs that US longwall mines utilize. The ANN network selected no degasification, GVB, horizontal and GVB, and horizontal, vertical and GVB options with high accuracy. The results suggest that the model can be used as a decision tool for degasification system selection using site- and mine-specific conditions. Such a model can also be used as a screening tool to decide which degasification design should be investigated in detail with more complex numerical techniques. [Copyright &y& Elsevier]
AB - Copyright of Computers & Geosciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAL networks (Computer science)
KW - HYDRAULIC engineering
KW - FLUID mechanics
KW - HYDRAULIC structures
KW - MINES & mineral resources -- Software
KW - METHANE
KW - CLASSIFICATION
KW - VENTILATION
KW - Artificial neural networks
KW - Classification
KW - Coal seam degasification
KW - Longwall mining
KW - Principal component analysis
KW - Ventilation
N1 - Accession Number: 36565533; Özgen Karacan, C. 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA 15236, USA; Source Info: Mar2009, Vol. 35 Issue 3, p515; Subject Term: NEURAL networks (Computer science); Subject Term: HYDRAULIC engineering; Subject Term: FLUID mechanics; Subject Term: HYDRAULIC structures; Subject Term: MINES & mineral resources -- Software; Subject Term: METHANE; Subject Term: CLASSIFICATION; Subject Term: VENTILATION; Author-Supplied Keyword: Artificial neural networks; Author-Supplied Keyword: Classification; Author-Supplied Keyword: Coal seam degasification; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Principal component analysis; Author-Supplied Keyword: Ventilation; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; NAICS/Industry Codes: 238910 Site Preparation Contractors; NAICS/Industry Codes: 562910 Remediation Services; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.cageo.2008.02.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36565533&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105479204
T1 - Active steps to promote influenza vaccination.
AU - Middleton G
Y1 - 2009/03//2009 Mar
N1 - Accession Number: 105479204. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Public Health; USA. Special Interest: Public Health. NLM UID: 101297401.
KW - Health Promotion -- Methods
KW - Immunization Programs -- Utilization
KW - Influenza -- Prevention and Control
KW - Influenza -- Immunology
KW - United States
SP - 61
EP - 62
JO - Disaster Medicine & Public Health Preparedness
JF - Disaster Medicine & Public Health Preparedness
JA - DISASTER MED PUBLIC HEALTH PREPAREDNESS
VL - 3
IS - 1
PB - Cambridge University Press
SN - 1935-7893
AD - Z-Tech, Office of the Civilian Volunteer Medical Reserve Corps. Grace.Middleton@hhs.gov
U2 - PMID: 19293744.
DO - 10.1097/DMP.0b013e318198485a
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kisby, G.E.
AU - Olivas, A.
AU - Park, T.
AU - Churchwell, M.
AU - Doerge, D.
AU - Samson, L.D.
AU - Gerson, S.L.
AU - Turker, M.S.
T1 - DNA repair modulates the vulnerability of the developing brain to alkylating agents
JO - DNA Repair
JF - DNA Repair
Y1 - 2009/03//
VL - 8
IS - 3
M3 - Article
SP - 400
EP - 412
SN - 15687864
AB - Abstract: Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly understood. The focus of the present study is to demonstrate that DNA damage plays a key role in disrupting neurodevelopment. To examine this hypothesis, we compared the cytotoxic and DNA damaging properties of the methylating agents methylazoxymethanol (MAM) and dimethyl sulfate (DMS) and the mono- and bifunctional alkylating agents chloroethylamine (CEA) and nitrogen mustard (HN2), in granule cell neurons derived from the cerebellum of neonatal wild type mice and three transgenic DNA repair strains. Wild type cerebellar neurons were significantly more sensitive to the alkylating agents DMS and HN2 than neuronal cultures treated with MAM or the half-mustard CEA. Parallel studies with neuronal cultures from mice deficient in alkylguanine DNA glycosylase (Aag −/−) or O 6-methylguanine methyltransferase (Mgmt −/−), revealed significant differences in the sensitivity of neurons to all four genotoxicants. Mgmt −/− neurons were more sensitive to MAM and HN2 than the other genotoxicants and wild type neurons treated with either alkylating agent. In contrast, Aag −/− neurons were for the most part significantly less sensitive than wild type or Mgmt −/− neurons to MAM and HN2. Aag −/− neurons were also significantly less sensitive than wild type neurons treated with either DMS or CEA. Granule cell development and motor function were also more severely disturbed by MAM and HN2 in Mgmt −/− mice than in comparably treated wild type mice. In contrast, cerebellar development and motor function were well preserved in MAM-treated Aag −/− or MGMT-overexpressing (Mgmt Tg+) mice, even as compared with wild type mice suggesting that AAG protein increases MAM toxicity, whereas MGMT protein decreases toxicity. Surprisingly, neuronal development and motor function were severely disturbed in Mgmt Tg+ mice treated with HN2. Collectively, these in vitro and in vivo studies demonstrate that the type of DNA lesion and the efficiency of DNA repair are two important factors that determine the vulnerability of the developing brain to long-term injury by a genotoxicant. [Copyright &y& Elsevier]
AB - Copyright of DNA Repair is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA repair
KW - NEURAL development
KW - DNA damage
KW - ALKYLATING agents
KW - CELL culture
KW - MICE as laboratory animals
KW - NITROGEN mustards
KW - Alkyladenine DNA glycosylase (Aag)
KW - Cerebellum
KW - Granule cell
KW - Methylazoxymethanol (MAM)
KW - Nitrogen mustard (HN2)
KW - O 6-Methylguanine methyltransferase (Mgmt)
N1 - Accession Number: 36404500; Kisby, G.E. 1; Email Address: kisby@ohsu.edu Olivas, A. 1 Park, T. 1 Churchwell, M. 2 Doerge, D. 2 Samson, L.D. 3 Gerson, S.L. 4 Turker, M.S. 1; Affiliation: 1: Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University, Portland, OR 97239, United States 2: National Center for Toxicological Research (NCTR), Jefferson, AR, United States 3: Biological Engineering Division, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States 4: Case Western Reserve University, Case Comprehensive Cancer Center, 10900 Euclid Avenue, Cleveland, OH 44106, United States; Source Info: Mar2009, Vol. 8 Issue 3, p400; Subject Term: DNA repair; Subject Term: NEURAL development; Subject Term: DNA damage; Subject Term: ALKYLATING agents; Subject Term: CELL culture; Subject Term: MICE as laboratory animals; Subject Term: NITROGEN mustards; Author-Supplied Keyword: Alkyladenine DNA glycosylase (Aag); Author-Supplied Keyword: Cerebellum; Author-Supplied Keyword: Granule cell; Author-Supplied Keyword: Methylazoxymethanol (MAM); Author-Supplied Keyword: Nitrogen mustard (HN2); Author-Supplied Keyword: O 6-Methylguanine methyltransferase (Mgmt); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.dnarep.2008.12.002
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Lawrence, John1
AU - Xiaobai Li2
T1 - A Multiple Comparisons Procedure for Comparing All Arms in Three-Arm Clinical Trials.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2009/03//
Y1 - 2009/03//
VL - 43
IS - 2
CP - 2
M3 - Article
SP - 177
EP - 184
SN - 00928615
AB - In three-arm studies, there are often multiple hypotheses to be tested among the arms. In this article, we describe a multiple comparisons procedure that controls the familywise error rate in the strong sense. The procedure is appropriate when one of the arms is a control, and both treatment arms will be compared to the control as well as to each other. The procedure is shown to be consistent and the asymptotic relative efficiency (compared to the uniformly most powerful test for the individual comparisons) is Close to 1 in many scenarios. Furthermore, the special case where the arms are placebo, active control, and test drug with one goal of showing noninferiority is examined. [ABSTRACT FROM AUTHOR]
KW - Error rates
KW - Clinical trials
KW - Multiple comparisons (Statistics)
KW - Hypothesis
KW - Biometry
KW - Medical research
N1 - Accession Number: 38228745; Authors: Lawrence, John 1; Xiaobai Li 2; Affiliations: 1: US Food and Drug Administration, Silver Spring, Maryland; 2: Center for Biostatistics, The Ohio State University, Columbus, Ohio; Subject: Clinical trials; Subject: Error rates; Subject: Multiple comparisons (Statistics); Subject: Hypothesis; Subject: Biometry; Subject: Medical research; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Wheeler, Matthew W.
AU - Bailer, A. John
T1 - Comparing model averaging with other model selection strategies for benchmark dose estimation.
JO - Environmental & Ecological Statistics
JF - Environmental & Ecological Statistics
Y1 - 2009/03//
VL - 16
IS - 1
M3 - Article
SP - 37
EP - 51
PB - Springer Science & Business Media B.V.
SN - 13528505
AB - Model averaging (MA) has been proposed as a method of accommodating model uncertainty when estimating risk. Although the use of MA is inherently appealing, little is known about its performance using general modeling conditions. We investigate the use of MA for estimating excess risk using a Monte Carlo simulation. Dichotomous response data are simulated under various assumed underlying dose–response curves, and nine dose–response models (from the USEPA Benchmark dose model suite) are fit to obtain both model specific and MA risk estimates. The benchmark dose estimates (BMDs) from the MA method, as well as estimates from other commonly selected models, e.g., best fitting model or the model resulting in the smallest BMD, are compared to the true benchmark dose value to better understand both bias and coverage behavior in the estimation procedure. The MA method has a small bias when estimating the BMD that is similar to the bias of BMD estimates derived from the assumed model. Further, when a broader range of models are included in the family of models considered in the MA process, the lower bound estimate provided coverage close to the nominal level, which is superior to the other strategies considered. This approach provides an alternative method for risk managers to estimate risk while incorporating model uncertainty. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental & Ecological Statistics is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Simulation methods & models
KW - Risk assessment
KW - Monte Carlo method
KW - Estimation theory
KW - Nominal measurement
KW - Risk managers
KW - Bayesian model averaging
KW - Model uncertainty
KW - Risk estimation
N1 - Accession Number: 36296278; Wheeler, Matthew W. 1; Email Address: aez0@cdc.gov; Bailer, A. John 1,2; Affiliations: 1: Risk Evaluation Branch, National Institute for Occupational Safety and Health, MS C-15, 4676 Columbia Parkway Cincinnati 45226 USA; 2: Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA; Issue Info: Mar2009, Vol. 16 Issue 1, p37; Thesaurus Term: Simulation methods & models; Thesaurus Term: Risk assessment; Subject Term: Monte Carlo method; Subject Term: Estimation theory; Subject Term: Nominal measurement; Subject Term: Risk managers; Author-Supplied Keyword: Bayesian model averaging; Author-Supplied Keyword: Model uncertainty; Author-Supplied Keyword: Risk estimation; Number of Pages: 15p; Illustrations: 1 Diagram, 2 Charts, 8 Graphs; Document Type: Article
L3 - 10.1007/s10651-007-0071-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36296278&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keshava, Channa
AU - Divi, Rao L.
AU - Einem, Tracey L.
AU - Richardson, Diana L.
AU - Leonard, Sarah L.
AU - Keshava, Nagalakshmi
AU - Poirier, Miriam C.
AU - Weston, Ainsley
T1 - Chiorophyllin Significantly Reduces Benzo [a] pyrene - DNA Adduct Formation and Alters Cytochrome P450 1A1 and 1B1 expression and EROD Activity in Normal Human Mammary Epithelial Cells.
JO - Environmental & Molecular Mutagenesis
JF - Environmental & Molecular Mutagenesis
Y1 - 2009/03//
VL - 50
IS - 2
M3 - Article
SP - 134
EP - 144
SN - 08936692
AB - The article presents a hypothesis which states that chlorophyllin (CHLN) can reduce benzo[a]pyrene-DNA (BP-DNA) adduct levels. It involves the measurement of BP-DNA adducts through the use of chemiluminescence immunoassay. In an aim to analyze metabolic mechanisms, there was a monitoring of expression using Affymetrix microarray. The hypothesis shows not only BP-induced up-regulation of CYP1A1 and CYP1B1 expression, but the upregulation of groups of interferon-inducible, inflammation and signal transduction genes as well. It shows that there was a decline in the expression of many genes when it comes to incubation of cells with CHLN and BP in any combination.
KW - Benzopyrene
KW - Polycyclic aromatic hydrocarbons
KW - Chlorophyllin
KW - Mutagenesis
KW - DNA
KW - Gene expression
KW - Chemiluminescence immunoassay
KW - Genetic regulation
KW - Hypothesis
KW - chemiluminescence immunoassay
KW - chemoprevention
KW - chlorophyllin
KW - interferon
KW - microarray
KW - NQO1
KW - polycyclic aromatic hydrocarbons
N1 - Accession Number: 36874647; Keshava, Channa 1,2; Divi, Rao L. 3; Einem, Tracey L. 3; Richardson, Diana L. 1; Leonard, Sarah L. 3; Keshava, Nagalakshmi 2; Poirier, Miriam C. 3; Email Address: poirierm@exchange.nih.gov; Weston, Ainsley 1,4; Affiliations: 1: Carcinogenesis Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; 2: National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Aye, NW, Washington, D.C.; 3: Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia; Issue Info: Mar2009, Vol. 50 Issue 2, p134; Thesaurus Term: Benzopyrene; Thesaurus Term: Polycyclic aromatic hydrocarbons; Subject Term: Chlorophyllin; Subject Term: Mutagenesis; Subject Term: DNA; Subject Term: Gene expression; Subject Term: Chemiluminescence immunoassay; Subject Term: Genetic regulation; Subject Term: Hypothesis; Author-Supplied Keyword: chemiluminescence immunoassay; Author-Supplied Keyword: chemoprevention; Author-Supplied Keyword: chlorophyllin; Author-Supplied Keyword: interferon; Author-Supplied Keyword: microarray; Author-Supplied Keyword: NQO1; Author-Supplied Keyword: polycyclic aromatic hydrocarbons; Number of Pages: 11p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/em.20449
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36874647&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Sang-Ho
AU - Lefèvre, Thiery
AU - Subirade, Muriel
AU - Paquin, Paul
T1 - Effects of ultra-high pressure homogenization on the properties and structure of interfacial protein layer in whey protein-stabilized emulsion
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2009/03//
VL - 113
IS - 1
M3 - Article
SP - 191
EP - 195
SN - 03088146
AB - Abstract: The effect of high pressure homogenization on the properties of whey protein adsorbed on emulsion interface was determined by competitive adsorption with Tween 20, Fourier transform infrared (FT-IR) spectroscopy, and RP-HPLC. The amount of whey proteins desorbed by Tween 20 increased at higher pressure. The results of FT-IR spectroscopy showed that higher homogenization pressures led to decrease of α-helix and increase of β-sheet indicating the formation of fewer interactions with the lipid phase and more interaction between adsorbed whey proteins, respectively. In RP-HPLC profile, the retention time of whey protein desorbed from high pressured emulsion was shorter than that from low-pressured emulsion. From these results, we have shown that higher pressures cause the formation of a more compact interfacial protein layer. Finally, “high pressure” emulsions are more stable than “low-pressure” ones, because of the protein layer formed by protein-protein interactions as well as the decrease of droplet size. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Analysis
KW - TECHNICAL chemistry
KW - SANITARY chemistry
KW - PRESSURE
KW - Emulsion
KW - High pressure homogenizer
KW - Interfacial structure
KW - Protein adsorption
KW - Whey protein
N1 - Accession Number: 34651185; Lee, Sang-Ho 1; Email Address: salutsh@kfda.go.kr Lefèvre, Thiery 2 Subirade, Muriel 2 Paquin, Paul 2; Affiliation: 1: Busan Regional Korea Food and Drug Administration, 123-7 Yongdang-dong, Busan, Korea 2: Centre de recherches en Sciences et Technologie du Lait (STELA), Faculté des sciences de l’agriculture et l’alimentation, Pavillon Paul-Comtois, Université Laval, Sainte-Foy, Québec, Canada; Source Info: Mar2009, Vol. 113 Issue 1, p191; Subject Term: FOOD -- Analysis; Subject Term: TECHNICAL chemistry; Subject Term: SANITARY chemistry; Subject Term: PRESSURE; Author-Supplied Keyword: Emulsion; Author-Supplied Keyword: High pressure homogenizer; Author-Supplied Keyword: Interfacial structure; Author-Supplied Keyword: Protein adsorption; Author-Supplied Keyword: Whey protein; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.foodchem.2008.07.067
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=34651185&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grossman, Joy M.
AU - Zayas-Cabán, Teresa
AU - Kemper, Nicole
T1 - Information Gap: Can Health Insurer Personal Health Records Meet Patients' And Physicians' Needs?
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/03//Mar/Apr2009
VL - 28
IS - 2
M3 - Article
SP - 377
EP - 389
PB - Project HOPE/HEALTH AFFAIRS
SN - 02782715
AB - Personal health records (PHRs), centralized places for people to electronically store and organize their health information, can benefit both patients and doctors. This qualitative study of health insurers' PHRs for enrollees reveals potential benefits and challenges. Insurers' ability to put claims-based data into the PHR offers an advantage. However, consumers are concerned about sharing personal health information with insurers and about Internet security. Physicians question (1) the validity of claims data in making treatment decisions and (2) whether accessing these PHRs is worth the disruptions to their workflow. This paper offers possible solutions that may lead to more widespread adoption of insurer PHRs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL records -- Management
KW - MEDICAL care
KW - MEDICAL informatics
KW - INFORMATION technology
KW - PUBLIC health
KW - ELECTRONIC systems
KW - HEALTH insurance
KW - PHYSICIAN & patient
KW - WORKFLOW
N1 - Accession Number: 44537910; Grossman, Joy M. 1; Email Address: jgrossman@hschange.org Zayas-Cabán, Teresa 2 Kemper, Nicole 3; Affiliation: 1: Senior Health Researcher, Center for Studying Health System Change (HSC), Washington,D.C. 2: Senior Manager, Health Information Technology, Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland. 3: Health Research Analyst, HSC, Washington,D.C.; Source Info: Mar/Apr2009, Vol. 28 Issue 2, p377; Subject Term: MEDICAL records -- Management; Subject Term: MEDICAL care; Subject Term: MEDICAL informatics; Subject Term: INFORMATION technology; Subject Term: PUBLIC health; Subject Term: ELECTRONIC systems; Subject Term: HEALTH insurance; Subject Term: PHYSICIAN & patient; Subject Term: WORKFLOW; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 13p; Document Type: Article
L3 - 10.1377/hlthaff.28.2.377
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44537910&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105475722
T1 - Investing in health information infrastructure: can it help achieve health reform?
AU - Clancy CM
AU - Anderson KM
AU - White PJ
Y1 - 2009/03//Mar/Apr2009
N1 - Accession Number: 105475722. Language: English. Entry Date: 20090424. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Informatics. NLM UID: 8303128.
KW - Health Care Reform
KW - Health Information Systems
KW - Information Technology -- Economics
KW - Quality of Health Care
KW - Clinical Indicators
KW - Communication Protocols
KW - Consent
KW - Data Collection Methods
KW - Data Security
KW - Electronic Data Interchange
KW - Health Care Delivery, Integrated
KW - Investments
KW - Organizational Efficiency
KW - Patient Identification
KW - Privacy and Confidentiality
KW - Reimbursement Mechanisms
SP - 478
EP - 482
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
IS - 2
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Health care reform has reemerged as a policy imperative. Congressional discussions regarding sizable federal investments in health information technology (IT) infrastructure have revitalized the vision of health IT as a critical component of accelerating improvements in the quality and value of health care for all Americans. Policymakers will be challenged to link investments in the health information infrastructure to the objectives of health care reform. The purpose of this paper is to articulate some near- and long-term steps that increase the likelihood of achieving high-value health care with the aid of health IT.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality (AHRQ) in Rockville, Maryland, USA. Carolyn.Clancy@ahrq.hhs.gov
U2 - PMID: 19276007.
DO - 10.1377/hlthaff.28.2.478
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105475722&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Holmes, Thomas D.
AU - Guilmett, Raymond A.
AU - Yung Sung Cheng
AU - Parkhurst, Mary Ann
AU - Hoover, Mark D.
T1 - AEROSOL SAMPLING SYSTEM FOR COLLECTION OF CAPSTONE DEPLETED URANIUM PARTICLES IN A HIGH-ENERGY ENVIRONMENT.
JO - Health Physics
JF - Health Physics
Y1 - 2009/03//
VL - 96
IS - 3
M3 - Article
SP - 227
EP - 237
SN - 00179078
AB - The article describes the experimental setup and sampling methodologies used to achieve the objectives of the Capstone Depleted Uranium (DU) Aerosol Study which was undertaken to obtain aerosol samples resulting from a large-caliber DU penetrator striking an Abrams or Bradley test vehicle. The sampling methodologies were designed to optimize the performance of the samplers and maintain their integrity in the extreme environment created during perforation of an armored vehicle by a DU penetrator. They were also designed to collect aerosols as a function of time post perforation, and obtain size-classified samples for analysis of chemical composition, particle morphology, and solubility in lung fluid.
KW - Radioactive aerosols
KW - Health risk assessment
KW - Hazardous substances -- Health aspects
KW - Depleted uranium -- Military applications
KW - Armored military vehicles
KW - Medical physics
KW - aerosols
KW - air sampling
KW - monitoring, air
KW - uranium, depleted
N1 - Accession Number: 36785841; Holmes, Thomas D. 1; Guilmett, Raymond A. 1; Yung Sung Cheng 1; Email Address: ycheng@lrri.org; Parkhurst, Mary Ann 2; Hoover, Mark D. 3; Affiliations: 1: Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE. Albuquerque, NM 87108; 2: Pacific Northwest National Laboratory. P.O. Box 999, Richland, WA 99352; 3: National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; Issue Info: Mar2009, Vol. 96 Issue 3, p227; Thesaurus Term: Radioactive aerosols; Thesaurus Term: Health risk assessment; Thesaurus Term: Hazardous substances -- Health aspects; Subject Term: Depleted uranium -- Military applications; Subject Term: Armored military vehicles; Subject Term: Medical physics; Author-Supplied Keyword: aerosols; Author-Supplied Keyword: air sampling; Author-Supplied Keyword: monitoring, air; Author-Supplied Keyword: uranium, depleted; NAICS/Industry Codes: 561613 Armored Car Services; NAICS/Industry Codes: 336992 Military Armored Vehicle, Tank, and Tank Component Manufacturing; NAICS/Industry Codes: 336990 Other transportation equipment manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 17p; Illustrations: 2 Black and White Photographs, 5 Diagrams, 6 Charts, 6 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36785841&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Park, Subok
AU - Badano, Aldo
AU - Gallas, Brandon D.
AU - Myers, Kyle J.
T1 - Incorporating Human Contrast Sensitivity in Model Observers for Detection Tasks.
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
Y1 - 2009/03//
VL - 28
IS - 3
M3 - Article
SP - 339
EP - 347
SN - 02780062
AB - Contrast sensitivity of the human visual system is a characteristic that can adversely affect human performance in detection tasks. In this paper, we propose a method for incorporating human contrast sensitivity in anthropomorphic model observers. In our method, we model human contrast sensitivity using the Barten model with the mean luminance of a region of interest centered at the signal location. In addition, one free parameter is varied to content the effect of the contrast sensitivity on the model observer's performance. We investigate our model of human contrast sensitivity in a channelized-Hotelling observer (CHO) with difference-of-Gaussian channels. We call the CHO incorporating the contrast sensitivity a contrast-sensitive CHO (CS-CHO). The human data from a psychophysical study by Park et al. [1] are used for comparing the performance of the CS-CHO to human performance. That study used Gaussian signals with six different signal intensities in non-Gaussian lumpy backgrounds. A value of the free parameter is chosen to match the performance of the CS-CHO to the mean human performance only at the strongest signal. Results show that the CS-CHO with the chosen value of the free parameter predicts the mean human performance at the five lower signal intensities. Our results show that the CS-CHO predicts human performance well as a function of signal intensity. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VISION testing
KW - DIAGNOSTIC imaging
KW - EYE
KW - MAGNETIC resonance imaging
KW - BRIGHTNESS temperature
KW - CHANGE-point problems
KW - Anthropomorphic observer
KW - channelized-Hotelling observer
KW - human contrast sensitivity
KW - lumpy backgrounds
KW - signal detection
N1 - Accession Number: 36942839; Park, Subok 1; Email Address: subok.park@fda.hhs.gov Badano, Aldo 1 Gallas, Brandon D. 1 Myers, Kyle J. 1; Affiliation: 1: NIBIB/CDRH Laboratory for the Assessment of Medical Imaging System, Division of Imaging and Applied Mathematics, Center for Devices and Radiological Health, Food and Drug Administration, White Oak, MD 20993 USA; Source Info: Mar2009, Vol. 28 Issue 3, p339; Subject Term: VISION testing; Subject Term: DIAGNOSTIC imaging; Subject Term: EYE; Subject Term: MAGNETIC resonance imaging; Subject Term: BRIGHTNESS temperature; Subject Term: CHANGE-point problems; Author-Supplied Keyword: Anthropomorphic observer; Author-Supplied Keyword: channelized-Hotelling observer; Author-Supplied Keyword: human contrast sensitivity; Author-Supplied Keyword: lumpy backgrounds; Author-Supplied Keyword: signal detection; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 9p; Illustrations: 2 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1109/TMI.2008.929096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36942839&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105542030
T1 - Accuracy of Medicare expenditures in the medical expenditure panel survey.
AU - Zuvekas SH
AU - Olin GL
Y1 - 2009///Spring2009
N1 - Accession Number: 105542030. Language: English. Entry Date: 20090703. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0171671.
KW - Accounting -- Standards
KW - Health Resource Utilization
KW - Medicare -- Economics
KW - Resource Databases, Health -- Evaluation
KW - Billing and Claims
KW - Correlational Studies
KW - Descriptive Statistics
KW - Logistic Regression
KW - Matched-Pair Analysis
KW - Panel Studies -- United States
KW - Reports
KW - Survey Research -- Methods
KW - United States
KW - Validation Studies
KW - Human
SP - 92
EP - 108
JO - Inquiry (00469580)
JF - Inquiry (00469580)
JA - INQUIRY
VL - 46
IS - 1
PB - Sage Publications Inc.
AB - This paper examines underreporting and underrepresentation of high expenditure cases in the Medical Expenditure Panel Survey (MEPS) and their implications for analyses. Our data come from a sample of Medicare beneficiaries in the MEPS who were matched to their Medicare claims and enrollment files, with supplemental data from the Medicare Current Beneficiary Survey (MCBS). Underreporting of expenditures affected all groups of Medicare beneficiaries in the matched sample, but uniformly so that behavioral analyses were largely unaffected. Straightforward adjustments to the MEPS expenditure estimates could align them with aggregate sources, such as the National Health Expenditure Accounts, while preserving underlying relationships between expenditures and key correlates.
SN - 0046-9580
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; Samuel.zuvekas@ahrq.hhs.gov
U2 - PMID: 19489486.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105542030&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Weida Tong
AU - Hong Fang
AU - Mendrick, Donna
T1 - Toxicogenomics and Cell-Based Assays for Toxicology.
JO - Interdisciplinary Bio Central
JF - Interdisciplinary Bio Central
Y1 - 2009/03//
IS - 1
M3 - Article
SP - 1
EP - 5
PB - Interdisciplinary Bio Central
SN - 20058543
AB - Toxicity is usually investigated using a set of standardized animal-based studies which, unfortunately, fail to detect all compounds that induce human adverse events and do not provide detailed mechanistic information of observed toxicity. As an alternative to conventional toxicology, toxicogenomics takes advantage of currently advanced technologies in genomics, proteomics, metabolomics, and bioinformatics to gain a molecular level understanding of toxicity and to enhance the predictive power of toxicity testing in drug development and risk/safety assessment. In addition, there has been a renewed interest, particularly in various government agencies, to prioritize and/or supplement animal testing with a battery of mechanistically informative in vitro assays. This article provides a brief summary of the issues, challenges and lessons learned in these fields and discuss the ways forward to further advance toxicology using these technologies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Interdisciplinary Bio Central is the property of Interdisciplinary Bio Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOGENOMICS
KW - TOXICOLOGY
KW - ASSAYING
KW - ANIMAL experimentation
KW - PROTEOMICS
KW - cell-based assay
KW - MAQC
KW - microarrays
KW - toxicogenomics
N1 - Accession Number: 59258116; Weida Tong 1; Email Address: Weida.tong@fda.hhs.gov Hong Fang 2 Mendrick, Donna 1; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA 2: Z-Tech, an ICF International Company at FDA's National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: 2009, Issue 1, Special section p1; Subject Term: TOXICOGENOMICS; Subject Term: TOXICOLOGY; Subject Term: ASSAYING; Subject Term: ANIMAL experimentation; Subject Term: PROTEOMICS; Author-Supplied Keyword: cell-based assay; Author-Supplied Keyword: MAQC; Author-Supplied Keyword: microarrays; Author-Supplied Keyword: toxicogenomics; Number of Pages: 5p; Document Type: Article
L3 - 10.4051/ibc.2009.3.0010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=59258116&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - de Zwart, Onno
AU - Veldhuijzen, Irene K.
AU - Elam, Gillian
AU - Aro, Arja R.
AU - Abraham, Thomas
AU - Bishop, George D.
AU - Voeten, Hélène A. C. M.
AU - Richardus, Jan Hendrik
AU - Brug, Johannes
T1 - Perceived Threat, Risk Perception, and Efficacy Beliefs Related to SARS and Other (Emerging) Infectious Diseases: Results of an International Survey.
JO - International Journal of Behavioral Medicine
JF - International Journal of Behavioral Medicine
Y1 - 2009/03//
VL - 16
IS - 1
M3 - Article
SP - 30
EP - 40
PB - Springer Science & Business Media B.V.
SN - 10705503
AB - To study the levels of perceived threat, perceived severity, perceived vulnerability, response efficacy, and self-efficacy for severe acute respiratory syndrome (SARS) and eight other diseases in five European and three Asian countries. A computer-assisted phone survey was conducted among 3,436 respondents. The questionnaire focused on perceived threat, vulnerability, severity, response efficacy, and self-efficacy related to SARS and eight other diseases. Perceived threat of SARS in case of an outbreak in the country was higher than that of other diseases. Perceived vulnerability of SARS was at an intermediate level and perceived severity was high compared to other diseases. Perceived threat for SARS varied between countries in Europe and Asia with a higher perceived severity of SARS in Europe and a higher perceived vulnerability in Asia. Response efficacy and self-efficacy for SARS were higher in Asia compared to Europe. In multiple linear regression analyses, country was strongly associated with perceived threat. The relatively high perceived threat for SARS indicates that it is seen as a public health risk and offers a basis for communication in case of an outbreak. The strong association between perceived threat and country and different regional patterns require further research. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Behavioral Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISK perception
KW - SARS (Disease)
KW - RESPIRATORY diseases
KW - COMMUNICABLE diseases
KW - RISK communication
KW - SURVEYS
KW - Efficacy beliefs
KW - Infectious diseases
KW - International comparison
KW - Risk communication
KW - Risk perception
KW - SARS
N1 - Accession Number: 40926521; de Zwart, Onno 1,2; Email Address: dezwarto@ggd.rotterdam.nl Veldhuijzen, Irene K. 1,2 Elam, Gillian 3 Aro, Arja R. 4 Abraham, Thomas 5 Bishop, George D. 6 Voeten, Hélène A. C. M. 2 Richardus, Jan Hendrik 1 Brug, Johannes 7; Affiliation: 1: Division of Infectious Diseases Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands 2: Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 3: Health Protection Agency—Centre for Infections, London, UK 4: Unit for Health Promotion Research, University of Southern Denmark, Esbjerg, Denmark 5: Journalism and Media Study Centre, The University of Hong Kong, Hong Kong, Hong Kong 6: Department of Psychology, National University of Singapore, Singapore, Singapore 7: EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands; Source Info: Mar2009, Vol. 16 Issue 1, p30; Subject Term: RISK perception; Subject Term: SARS (Disease); Subject Term: RESPIRATORY diseases; Subject Term: COMMUNICABLE diseases; Subject Term: RISK communication; Subject Term: SURVEYS; Author-Supplied Keyword: Efficacy beliefs; Author-Supplied Keyword: Infectious diseases; Author-Supplied Keyword: International comparison; Author-Supplied Keyword: Risk communication; Author-Supplied Keyword: Risk perception; Author-Supplied Keyword: SARS; Number of Pages: 11p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s12529-008-9008-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40926521&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vartti, A.-M.
AU - Oenema, A.
AU - Schreck, M.
AU - Uutela, A.
AU - de Zwart, O.
AU - Brug, J.
AU - Aro, A. R.
T1 - SARS Knowledge, Perceptions, and Behaviors: a Comparison between Finns and the Dutch during the SARS Outbreak in 2003.
JO - International Journal of Behavioral Medicine
JF - International Journal of Behavioral Medicine
Y1 - 2009/03//
VL - 16
IS - 1
M3 - Article
SP - 41
EP - 48
PB - Springer Science & Business Media B.V.
SN - 10705503
AB - The SARS outbreak served to test both local and international outbreak management and risk communication practices. The study compares SARS knowledge, perceptions, behaviors, and information between Finns and the Dutch during the SARS outbreak in 2003. The participants of the study, who used a modified SARS Psychosocial Research Consortium survey, were drawn from Internet panels in Finland ( n = 308) and the Netherlands ( n = 373) in June 2003. Multiple logistic regression analyses were used to calculate odds ratios (with 95% confidence intervals) to compare Finns with the Dutch for various levels of perceptions and behaviors. Adjusted for age, education, and income, Finns were more likely to be knowledgeable and worried about SARS as well as to have low perceived comparative SARS risk and poor personal efficacy beliefs about preventing SARS. Finns were also more likely than the Dutch to have high confidence in physicians on SARS issues but less likely to have received information from the Internet and have confidence in Internet information. The study shed light on how two European populations differed substantially regarding lay responses to SARS. Understanding these differences is needed in formulating and executing communication and outbreak management. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Behavioral Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - SARS (Disease)
KW - PERCEPTION
KW - BEHAVIOR
KW - INFORMATION resources
KW - CULTURE
KW - Behavior
KW - Culture
KW - Information sources
KW - Lay knowledge
KW - Perception
KW - SARS
N1 - Accession Number: 40926527; Vartti, A.-M. 1,2; Email Address: anne-marie.vartti@thl.fi Oenema, A. 3 Schreck, M. 1 Uutela, A. 1 de Zwart, O. 3,4 Brug, J. 3,4 Aro, A. R. 5; Affiliation: 1: Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare (THL), Mannerheimintie 166, FIN-00300 Helsinki, Finland 2: Centre for Biothreat Preparedness, Cntr Military Medicine, The Finnish Defence Forces, Helsinki, Finland 3: Department of Public Health, Erasmus MC, Rotterdam, The Netherlands 4: Division of Infectious Disease Control, Municipal Public Health Service, Rotterdam-Rijnmond, The Netherlands 5: Unit for Health Promotion Research, University of Southern Denmark, Esbjerg, Denmark; Source Info: Mar2009, Vol. 16 Issue 1, p41; Subject Term: RESEARCH; Subject Term: SARS (Disease); Subject Term: PERCEPTION; Subject Term: BEHAVIOR; Subject Term: INFORMATION resources; Subject Term: CULTURE; Author-Supplied Keyword: Behavior; Author-Supplied Keyword: Culture; Author-Supplied Keyword: Information sources; Author-Supplied Keyword: Lay knowledge; Author-Supplied Keyword: Perception; Author-Supplied Keyword: SARS; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1007/s12529-008-9004-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40926527&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xinyi Jiang
AU - Elam, Gillian
AU - Yuen, Cicely
AU - Voeten, Helene
AU - Zwart, Onno
AU - Veldhuijzen, Irene
AU - Brug, Johannes
T1 - The Perceived Threat of SARS and its Impact on Precautionary Actions and Adverse Consequences: A Qualitative Study Among Chinese Communities in the United Kingdom and the Netherlands.
JO - International Journal of Behavioral Medicine
JF - International Journal of Behavioral Medicine
Y1 - 2009/03//
VL - 16
IS - 1
M3 - Article
SP - 58
EP - 67
PB - Springer Science & Business Media B.V.
SN - 10705503
AB - Although the SARS outbreak involved few probable cases of infection in Europe, swift international spread of infections raised the possibility of outbreaks. In particular, SARS presented a sociopsychological and economic threat to European Chinese communities because of their close links with the outbreak’s origins. A qualitative study was conducted among Chinese residents in the United Kingdom and the Netherlands to identify the origins of SARS risk perceptions and their impact on precautionary actions and adverse consequences from the perspective of vulnerable communities living in unaffected regions. Analysis was informed by protection motivation theory. Results revealed that information from affected Asia influenced risk perceptions and protective behavior among the Chinese in Europe when more relevant local information was absent. When high risk perceptions were combined with low efficacy regarding precautionary measures, avoidance-based precautionary action appeared to dominate responses to SARS. These actions may have contributed to the adverse impacts of SARS on the communities. Experiences of European Chinese communities suggest that practical and timely information, and consistent implementation of protective measures from central governments are essential to protect vulnerable populations in unaffected regions from unnecessary alarm and harm during outbreaks of emerging infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Behavioral Medicine is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SARS (Disease)
KW - CHINESE
KW - RISK perception
KW - RISK society
KW - RESPIRATORY diseases
KW - QUALITATIVE research
KW - Chinese population
KW - Precautionary behavior
KW - Protection motivation theory
KW - Qualitative
KW - Risk perceptions
KW - Severe acute respiratory syndrome (SARS)
N1 - Accession Number: 40926518; Xinyi Jiang 1,2,3; Email Address: x.y.jiang@dundee.ac.uk Elam, Gillian 1 Yuen, Cicely 4 Voeten, Helene 5 Zwart, Onno 4,5 Veldhuijzen, Irene 4 Brug, Johannes 5,6; Affiliation: 1: Health Protection Agency—Centre for Infections, London, UK 2: College of Art, Science & Engineering, University of Dundee, Dundee, UK 3: Queen Mother Building, University of Dundee, Dundee DD1 4HN, UK 4: Municipal Public Health Service Rotterdam Area, Rotterdam, the Netherlands 5: Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands 6: EMGO Institute VU University Medical Center, Amsterdam, the Netherlands; Source Info: Mar2009, Vol. 16 Issue 1, p58; Subject Term: SARS (Disease); Subject Term: CHINESE; Subject Term: RISK perception; Subject Term: RISK society; Subject Term: RESPIRATORY diseases; Subject Term: QUALITATIVE research; Author-Supplied Keyword: Chinese population; Author-Supplied Keyword: Precautionary behavior; Author-Supplied Keyword: Protection motivation theory; Author-Supplied Keyword: Qualitative; Author-Supplied Keyword: Risk perceptions; Author-Supplied Keyword: Severe acute respiratory syndrome (SARS); Number of Pages: 10p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1007/s12529-008-9005-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40926518&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105472080
T1 - In memoriam: Martin C. Doot, MD.
AU - Dekker A
AU - Kushner M
Y1 - 2009/03//
N1 - Accession Number: 105472080. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article; obituary; pictorial. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9107051.
KW - Physicians -- Illinois
KW - Illinois
KW - Substance Abuse
KW - Substance Dependence
KW - Doot MC
SP - 87
EP - 88
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
JA - J ADDICT DIS
VL - 28
IS - 1
PB - Taylor & Francis Ltd
SN - 1055-0887
AD - Office of Health Programs, Phoenix Area Office, Indian Health Service; Anthony.dekker@ihs.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kotowski, Susan E.
AU - Davis, Kermit G.
AU - Waters, Thomas R.
T1 - Investigation of Select Ergonomic Interventions for Farm Youth. Part 1: Shovels.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2009/03//
VL - 14
IS - 1
M3 - Article
SP - 33
EP - 43
SN - 1059924X
AB - There is some evidence that performing farm chores may place youth at risk of musculoskeletal injuries. However, actual investigations of interventions for farm youth have been sparse. The objective of the current study was to investigate two different types of interventions (add-on handles) for shovels, potentially reducing the risk of injury in farm youth. A lumbar motion monitor was used to capture trunk posture and motion while the youth performed a simulated shoveling task—removal of material from an animal stall. Ratings of perceived exertion and comfort of use were also assessed. The results indicate add-on handles decreased sagittal flexion but increased twisting as compared to regular shovels. Perceived ratings were worse for shovels with add-on handles. Overall, there appears to be a trade-off between sagittal and nonsagittal motion and appears to have minimal impact on risk of low back injury. However, further research is necessary to determine the complete ramifications of this trade-off with respect to the biomechanical load within the low back and on other joints. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERGONOMICS
KW - AGRICULTURAL laborers -- Health
KW - MUSCULOSKELETAL system -- Wounds & injuries
KW - AGRICULTURAL engineering
KW - SHOVELS
KW - AGRICULTURAL equipment
KW - RISK management in business
KW - INDUSTRIAL safety
KW - AGRICULTURAL safety
KW - Farm youth
KW - interventions
KW - manual material handling
KW - musculoskeletal disorders
KW - shoveling
N1 - Accession Number: 36472624; Kotowski, Susan E. 1 Davis, Kermit G. 1; Email Address: kermit.davis@uc.edu Waters, Thomas R. 2; Affiliation: 1: Low Back and Biomechanics and Workplace Stress Laboratory, University of Cincinnati, Department of Environmental Health, Cincinnati, Ohio, USA 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: 2009, Vol. 14 Issue 1, p33; Subject Term: ERGONOMICS; Subject Term: AGRICULTURAL laborers -- Health; Subject Term: MUSCULOSKELETAL system -- Wounds & injuries; Subject Term: AGRICULTURAL engineering; Subject Term: SHOVELS; Subject Term: AGRICULTURAL equipment; Subject Term: RISK management in business; Subject Term: INDUSTRIAL safety; Subject Term: AGRICULTURAL safety; Author-Supplied Keyword: Farm youth; Author-Supplied Keyword: interventions; Author-Supplied Keyword: manual material handling; Author-Supplied Keyword: musculoskeletal disorders; Author-Supplied Keyword: shoveling; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; Number of Pages: 11p; Illustrations: 5 Black and White Photographs, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/10599240802612604
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36472624&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kotowski, Susan E.
AU - Davis, Kermit G.
AU - Waters, Thomas R.
T1 - Investigation of Select Ergonomic Interventions for Farm Youth. Part 2: Wheelbarrows.
JO - Journal of Agromedicine
JF - Journal of Agromedicine
Y1 - 2009/03//
VL - 14
IS - 1
M3 - Article
SP - 44
EP - 57
SN - 1059924X
AB - Previous research has provided evidence that farm youth performing farm chores may be at risk of developing a low back musculoskeletal injury. In order to reduce these risks, effective interventions for reducing the stressors that cause the injuries are needed. The objective of the current study was to investigate alternative wheelbarrow styles as an intervention for youth working to transfer material on the farm with respect to trunk motion and perceived exertion. A lumbar motion monitor was used to capture three-dimensional trunk kinematics while several wheelbarrow tasks (e.g., pushing, pushing over bump, and dumping) were performed by youth. Ratings of perceived exertion and comfort of use were also assessed. Results indicated a reduction in the sagittal trunk flexion and velocity was achieved by adding a push bar to the handles, in combination with three-wheels, or utilizing adjustable handles. However, these alterations had little impact in the predicted low back disorder risk levels. Additionally, the youths' perceptions of risk and exertion levels were greater for these alternative wheelbarrows than for the regular wheelbarrow. Therefore, the mismatch between perception and kinematic response will probably affect usage of the alternative wheelbarrows. While the results indicate that alternative wheelbarrow designs can reduce the awkward postures and motions during wheelbarrow tasks, further research into the effectiveness of these interventions, including spine loading and long long-term use, is necessary. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Agromedicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ERGONOMICS
KW - AGRICULTURAL laborers -- Health
KW - MUSCULOSKELETAL system -- Wounds & injuries
KW - AGRICULTURAL engineering
KW - WHEELBARROWS
KW - AGRICULTURAL equipment
KW - INDUSTRIAL safety
KW - RISK exposure
KW - RISK management in business
KW - Farm youth
KW - interventions
KW - manual material handling
KW - musculoskeletal disorders
KW - wheelbarrow
N1 - Accession Number: 36472623; Kotowski, Susan E. 1 Davis, Kermit G. 1; Email Address: kermit.davis@uc.edu Waters, Thomas R. 2; Affiliation: 1: Department of Environmental Health, Low Back Biomechanics and Workplace Stress Laboratory, University of Cincinnati, Cincinnati, Ohio, USA 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Source Info: 2009, Vol. 14 Issue 1, p44; Subject Term: ERGONOMICS; Subject Term: AGRICULTURAL laborers -- Health; Subject Term: MUSCULOSKELETAL system -- Wounds & injuries; Subject Term: AGRICULTURAL engineering; Subject Term: WHEELBARROWS; Subject Term: AGRICULTURAL equipment; Subject Term: INDUSTRIAL safety; Subject Term: RISK exposure; Subject Term: RISK management in business; Author-Supplied Keyword: Farm youth; Author-Supplied Keyword: interventions; Author-Supplied Keyword: manual material handling; Author-Supplied Keyword: musculoskeletal disorders; Author-Supplied Keyword: wheelbarrow; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 333924 Industrial Truck, Tractor, Trailer, and Stacker Machinery Manufacturing; NAICS/Industry Codes: 333920 Material handling equipment manufacturing; Number of Pages: 14p; Illustrations: 4 Black and White Photographs, 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/10599240802612653
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36472623&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siddiqui, Ohidul
AU - Hung, H. M. James
AU - O'Neill, Robert
T1 - MMRM vs. LOCF: A Comprehensive Comparison Based on Simulation Study and 25 NDA Datasets.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2009/03//Mar/Apr2009
VL - 19
IS - 2
M3 - Article
SP - 227
EP - 246
PB - Taylor & Francis Ltd
SN - 10543406
AB - In recent years, the use of the last observation carried forward (LOCF) approach in imputing missing data in clinical trials has been greatly criticized, and several likelihood-based modeling approaches are proposed to analyze such incomplete data. One of the proposed likelihood-based methods is the Mixed-Effect Model Repeated Measure (MMRM) model. To compare the performance of LOCF and MMRM approaches in analyzing incomplete data, two extensive simulation studies are conducted, and the empirical bias and Type I error rates associated with estimators and tests of treatment effects under three missing data paradigms are evaluated. The simulation studies demonstrate that LOCF analysis can lead to substantial biases in estimators of treatment effects and can greatly inflate Type I error rates of the statistical tests, whereas MMRM analysis on the available data leads to estimators with comparatively small bias, and controls Type I error rates at a nominal level in the presence of missing completely at random (MCAR) or missing at random (MAR) and some possibility of missing not at random (MNAR) data. In a sensitivity analysis of 48 clinical trial datasets obtained from 25 New Drug Applications (NDA) submissions of neurological and psychiatric drug products, MMRM analysis appears to be a superior approach in controlling Type I error rates and minimizing biases, as compared to LOCF ANCOVA analysis. In the exploratory analyses of the datasets, no clear evidence of the presence of MNAR missingness is found. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - MEDICAL experimentation on humans
KW - MISSING data (Statistics)
KW - ERROR rates
KW - MEDICAL research
KW - RESEARCH -- Methodology
KW - Ignorable missing data
KW - Last observation carried forward
KW - Missing at random
KW - Missing completely at random
KW - Missing not at random
N1 - Accession Number: 36460290; Siddiqui, Ohidul 1; Email Address: ohidul.siddiqui@fda.hhs.gov Hung, H. M. James 1 O'Neill, Robert 1; Affiliation: 1: Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Mar/Apr2009, Vol. 19 Issue 2, p227; Subject Term: CLINICAL trials; Subject Term: MEDICAL experimentation on humans; Subject Term: MISSING data (Statistics); Subject Term: ERROR rates; Subject Term: MEDICAL research; Subject Term: RESEARCH -- Methodology; Author-Supplied Keyword: Ignorable missing data; Author-Supplied Keyword: Last observation carried forward; Author-Supplied Keyword: Missing at random; Author-Supplied Keyword: Missing completely at random; Author-Supplied Keyword: Missing not at random; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 20p; Illustrations: 5 Charts, 8 Graphs; Document Type: Article
L3 - 10.1080/10543400802609797
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36460290&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105463561
T1 - Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study.
AU - Zhao P
AU - Ragueneau-Majlessi I
AU - Zhang L
AU - Strong JM
AU - Reynolds KS
AU - Levy RH
AU - Thummel KE
AU - Huang SM
Y1 - 2009/03//
N1 - Accession Number: 105463561. Language: English. Entry Date: 20090501. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Public Health. NLM UID: 0366372.
KW - Biological Availability
KW - Dosage Calculation
KW - Drug Interactions
KW - Ketoconazole -- Pharmacodynamics
KW - Ketoconazole -- Pharmacokinetics
KW - Crossover Design
KW - Data Analysis Software
KW - Equipment and Supplies
KW - Simulations
KW - United States Food and Drug Administration
KW - Human
SP - 351
EP - 359
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
JA - J CLIN PHARMACOL
VL - 49
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - The US Food and Drug Administration draft drug interaction guidance recommends that 400 mg ketoconazole (KTZ) be administered once daily for several days (QD400) for maximal CYP3A inhibition. Some investigators suggest that a single dose of 400 mg (SD400) KTZ is sufficient given its short half-life (t(1/2) approximately 3-5 hr). To determine the impact of KTZ regimens on CYP3A inhibition, we simulated AUC fold-change (AUCR) in the presence of SD400, QD400, or 200 mg twice-daily (BID200) KTZ for theoretical CYP3A substrates. Ratios of AUCR (AUCR(QD400)/AUCR(SD400) and AUCR(BID200) AUCR(QD400)) increase with increasing bioavailability and increasing substrate t(1/2). The SD400 KTZ regimen may provide maximal inhibition only for a subset of substrates (ie, low bioavailability and short t(1/2)). For substrates with t(1/2) longer than that of KTZ, multiple KTZ dosing is critical and BID200 appears to provide greater inhibition than QD400. Also, timing of KTZ administration should be optimized to allow maximal presystemic enzyme inhibition prior to substrate administration.
SN - 0091-2700
AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Room 3188, Building 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002; shiewmei.huang@fda.hhs.gov.
U2 - PMID: 19246732.
DO - 10.1177/0091270008331196
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Stivers, Andrew E.
AD - US Food and Drug Administration, College Park, MD
T1 - Regulating Market Language: Market Failure in Descriptive Signals
JO - Journal of Consumer Policy
JF - Journal of Consumer Policy
Y1 - 2009/03//
VL - 32
IS - 1
SP - 23
EP - 41
SN - 01687034
N1 - Accession Number: 1038723; Keywords: Information; Information Transmission; Regulation; Signals; Publication Type: Journal Article; Update Code: 200905
N2 - Truth-telling regulations in market language are commonly understood to be necessary to allow credible information transmission by sellers. These requirements turn natural language into a set of signals that can be used to differentiate products. But while these regulations solve the information problem, they do not necessarily solve an underlying market failure of allocation of language resources. It is this failure in allocation that regulators use to justify explicit rules allowing, requiring, or banning certain uses of market language. Given this justification, the obvious issue is what criteria should be used to impose, or not, specific language requirements. This paper uses a rich model of language to illustrate the justification for regulating language and develops a rough set of criteria for applying language regulations.
KW - Consumer Protection D18
KW - Search; Learning; Information and Knowledge; Communication; Belief D83
KW - Economic Sociology; Economic Anthropology; Social and Economic Stratification Z13
L3 - http://link.springer.com/journal/volumesAndIssues/10603
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UR - http://dx.doi.org/10.1007/s10603-009-9091-z
UR - http://link.springer.com/journal/volumesAndIssues/10603
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Steven J. Page
AU - Jon C. Volkwein
T1 - A revised conversion factor relating respirable dust concentrations measured by 10 mm Dorr-Oliver nylon cyclones operated at 1.7 and 2.0 L min−1Electronic supplementary information (ESI) available: Appendix B: General analytical model (B-1) and weight variable estimation (B-2). See DOI: 10.1039/b817922k
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2009/03//
VL - 11
IS - 3
M3 - Article
SP - 684
EP - 689
SN - 14640325
AB - Accurate measurement of workplace respirable dust concentration is an essential step in eliminating lung disease in any occupational setting. In the United States (U.S.) coal mining industry, this measurement process has relied upon a personal sampler that includes a 10 mm Dorr-Oliver (DO) nylon cyclone operated at a flow rate of 2.0 L min−1to collect a respirable dust sample. Dust concentrations measured with this sampler are multiplied by 1.38, which was empirically derived, to convert them to measurements approximating the United Kingdom British Medical Research Council (BMRC) definition of respirable dust upon which the health effects of coal mine dust are based. The International Organization for Standardization (ISO) subsequently refined the respirable dust definition and the U.S. National Institute for Occupational Safety and Health (NIOSH) 1995 Criteria for a Recommended Standard presented a conversion multiplier of 0.857 to apply to the 2.0 L min−1DO (in addition to the1.38 multiplier) to obtain equivalent ISO concentrations, as approximated by the 1.7 L min−1DO. However, the conversion multiplier 0.857 was derived indirectly from a limited size distribution data set rather than a direct comparison of the DO samplers. The present analysis focuses on providing a more accurate conversion multiplier derived from direct comparisons of the 2.0 L min−1(with 1.38 BMRC equivalency multiplier) and 1.7 L min−1DO cyclones. A weighted linear regression analysis of this database suggests that a more accurate estimate of the conversion multiplier is 0.815. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mineral dusts
KW - Strip mining -- Dust control
KW - Environmental protection
KW - Chemical engineering
N1 - Accession Number: 36881457; Steven J. Page 1; Jon C. Volkwein 1; Affiliations: 1: US Department of Health and Human Services; Issue Info: Mar2009, Vol. 11 Issue 3, p684; Thesaurus Term: Mineral dusts; Thesaurus Term: Strip mining -- Dust control; Thesaurus Term: Environmental protection; Thesaurus Term: Chemical engineering; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Choi, Younju
AU - Kim, Jiyung
AU - Lee, Haeng-Shin
AU - Kim, Cho-il
AU - Hwang, In Kyeong
AU - Park, Hye Kyung
AU - Oh, Chang-Hwan
T1 - Selenium content in representative Korean foods
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2009/03//
VL - 22
IS - 2
M3 - Article
SP - 117
EP - 122
SN - 08891575
AB - Abstract: This study was conducted to create a selenium database for the representative food items in Korean diet and to estimate the dietary selenium intake of Koreans. Three samples for each food item selected based on the result of the Korea National Health and Nutrition Examination Survey II (KNHANES II) were purchased in markets with a nationwide distribution channel and some local retail stores. Each pooled sample was analyzed in triplicate by ICP–MS after thorough homogenization. The rich sources of selenium were fish, shellfish and their products (0.152–0.788μg/g), eggs (0.267μg/g), and meats and poultry (0.043–0.324μg/g). Vegetables and fruits contained trace amounts of selenium (trace–0.052μg/g). The major food sources of selenium intake were grains and cereals (34%), fish and shellfish (21%) and meats and poultry (20%). The selenium intake of the Korean population was estimated by combining the selenium contents of frequently consumed foods in KNHANES II, of which the data was collected by 24-h recall method. The estimated and mean intake values reported for Koreans were 57.5μg/person/day. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Analysis
KW - SELENIUM
KW - HORTICULTURAL crops
KW - NATIVE element minerals
KW - Database
KW - Dietary intake
KW - Food composition
KW - Food safety
KW - Korean foods
KW - National food database
KW - Safe and adequate level
KW - Selenium
N1 - Accession Number: 36967634; Choi, Younju 1 Kim, Jiyung 2 Lee, Haeng-Shin 3 Kim, Cho-il 3 Hwang, In Kyeong 4 Park, Hye Kyung 1 Oh, Chang-Hwan 5; Email Address: changhwan@hanmail.net; Affiliation: 1: Korea Food and Drug Administration, The Bureau of Risk Management, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, Republic of Korea 2: Ottogi Research Center, 160 Pyeongchon-dong, Dongan-ku, Anyang, Kyeoggi-do, 431-070 Seoul, Republic of Korea 3: Center for Nutrition Policy and Promotion, Korea Health Industry Development Institute, 57-1 Noryangjin-Dong, Dongjak-Gu, Seoul 156-800, Republic of Korea 4: Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, 151-742, Seoul, Republic of Korea 5: Department of Oriental Medical Food and Nutrition, Semyung University, 117 Semyung-ro, Jecheon, Chungbuk 390-711, Republic of Korea; Source Info: Mar2009, Vol. 22 Issue 2, p117; Subject Term: FOOD -- Analysis; Subject Term: SELENIUM; Subject Term: HORTICULTURAL crops; Subject Term: NATIVE element minerals; Author-Supplied Keyword: Database; Author-Supplied Keyword: Dietary intake; Author-Supplied Keyword: Food composition; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: Korean foods; Author-Supplied Keyword: National food database; Author-Supplied Keyword: Safe and adequate level; Author-Supplied Keyword: Selenium; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jfca.2008.11.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36967634&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McEGAN, R.
AU - FU, T. J.
AU - WARRINER, K.
T1 - Concentration and Detection of Salmonella in Mung Bean Sprout Spent Irrigation Water by Use of Tangential Flow Filtration Coupled with an Amperometric Flowthrough Enzyme-Linked Immunosorbent Assay.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/03//
VL - 72
IS - 3
M3 - Article
SP - 591
EP - 600
SN - 0362028X
AB - The development of a culture-free method for Salmonella screening of spent irrigation water derived from sprouting mung bean beds is described. The system used tangential flow filtration (TFF) to nonspecifically concentrate cells from large (2- to 10-liter) sample volumes. The retentate (100 ml) from the TFF was then flowed over an anti-Salmonella antibody-modified cellulose acetate membrane. The captured Salmonella was detected by reacting with a secondary anti-Salmonella and goat anti-rabbit biotin labeled antibody, followed by avidin-tagged glucose oxidase. The hydrogen peroxide generated from the enzymic oxidation of glucose was amperometrically detected at an underlying platinum electrode. It was found that 10 liters of Salmonella suspensions of 2 log CFU/ml could be concentrated to 4 log CFU/ml with 60% recovery regardless of the flow rate (112 to 511 ml/min) or transmembrane pressure (0 to 20 lb/in²) applied. The solids content of spent irrigation water negatively affected the filtration rate of TFE This was most evident in spent irrigation water collected in the initial 24 h of the sprouting period, where the solids content was high (4,170 mg/liter) compared with samples collected at 96 h (560 mg/ liter). Trials were performed using mung bean beds inoculated with different Salmonella levels (1.3 to 3.3 log CFU/g). By using the optimized TFF and flowthrough immunoassay it was possible to detect Salmonella in spent irrigation water at levels of 2.43 log CFU/ml within 4 h. The integrated concentration and detection system will provide a useful tool for sprout producers to perform in-house pathogen screening of spent irrigation water. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Irrigation water
KW - Water -- Filtration
KW - Phytopathogenic microorganisms -- Detection
KW - Sprouts
KW - Mung bean
KW - Enzyme-linked immunosorbent assay
N1 - Accession Number: 37010288; McEGAN, R. 1; FU, T. J. 2; WARRINER, K. 1; Email Address: kwarrine@uoguelph.ca; Affiliations: 1: Department of Food Science, University of Guelph, Guelph, Ontario NIG 2W1, Canada; 2: U.S. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501, USA; Issue Info: Mar2009, Vol. 72 Issue 3, p591; Thesaurus Term: Salmonella; Thesaurus Term: Irrigation water; Thesaurus Term: Water -- Filtration; Subject Term: Phytopathogenic microorganisms -- Detection; Subject Term: Sprouts; Subject Term: Mung bean; Subject Term: Enzyme-linked immunosorbent assay; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - NEWSOME, R.
AU - TRAN, N.
AU - PAOLI, G. M.
AU - JAYKUS, L. A.
AU - TOMPKIN, B.
AU - MILIOTIS, M.
AU - RUTHMAN, T.
AU - HARTNETT, E.
AU - BUSTA, F. F.
AU - PETERSEN, B.
AU - SHANK, F.
AU - MCENTIRE, J.
AU - HOTCHKISS, J.
AU - WAGNER, M.
AU - SCHAFFNER, D. W.
T1 - Development of a Risk-Ranking Framework to Evaluate Potential High-Threat Microorganisms, Toxins, and Chemicals in Food.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2009/03//
VL - 74
IS - 2
M3 - Article
SP - R39
EP - R45
SN - 00221147
AB - Through a cooperative agreement with the U.S. Food and Drug Administration, the Institute of Food Technologists developed a risk-ranking framework prototype to enable comparison of microbiological and chemical hazards in foods and to assist policy makers, risk managers, risk analysts, and others in determining the relative public health impact of specific hazard–food combinations. The prototype is a bottom-up system based on assumptions that incorporate expert opinion/insight with a number of exposure and hazard-related risk criteria variables, which are propagated forward with food intake data to produce risk-ranking determinations. The prototype produces a semi-quantitative comparative assessment of food safety hazards and the impacts of hazard control measures. For a specific hazard–food combination the prototype can produce a single metric: a final risk value expressed as annual pseudo-disability adjusted life years (pDALY). The pDALY is a harmonization of the very different dose–response relationships observed for chemicals and microbes. The prototype was developed on 2 platforms, a web-based user interface and an Analytica® model (Lumina Decision Systems, Los Gatos, Calif., U.S.A.). Comprising visual basic language, the web-based platform facilitates data input and allows use concurrently from multiple locations. The Analytica model facilitates visualization of the logic flow, interrelationship of input and output variables, and calculations/algorithms comprising the prototype. A variety of sortable risk-ranking reports and summary information can be generated for hazard–food pairs, showing hazard and dose–response assumptions and data, per capita consumption by population group, and annual p-DALY. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIOLOGY
KW - FOOD
KW - PUBLIC health
KW - FOOD industry
KW - WEB-based user interfaces
KW - food safety
KW - risk
KW - risk ranking
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36938664; NEWSOME, R. 1; Email Address: rlnewsome@ift.org TRAN, N. 2 PAOLI, G. M. 3 JAYKUS, L. A. 4 TOMPKIN, B. 5 MILIOTIS, M. 6 RUTHMAN, T. 3 HARTNETT, E. 3 BUSTA, F. F. 7 PETERSEN, B. 2 SHANK, F. MCENTIRE, J. 1 HOTCHKISS, J. 8 WAGNER, M. 9 SCHAFFNER, D. W. 10; Affiliation: 1: Inst. of Food Technologists, Chicago, IL 60607, U.S.A. 2: Exponent, Inc., Washington, DC 20036, U.S.A. 3: Decisionalysis Risk Consultants, Inc., Ottawa, Ontario, Canada K1H653 4: North Carolina State Univ., Raleigh, NC 27695, U.S.A. 5: ConAgra, LaGrange, IL 60525, U.S.A. 6: Food and Drug Administration/Center for Food Safety and Applied Nutrition College Park, MD 20740, U.S.A. 7: Natl. Center for Food Protection and Defense and Univ. of Minnesota,Minneapolis,MN55455, U.S.A. 8: Cornell Univ., Ithaca, NY 14853, U.S.A. 9: Mars Symbioscience, Rockville, MD 20850, U.S.A. 10: Rutgers Univ., New Brunswick, NJ 08901, U.S.A.; Source Info: Mar2009, Vol. 74 Issue 2, pR39; Subject Term: MICROBIOLOGY; Subject Term: FOOD; Subject Term: PUBLIC health; Subject Term: FOOD industry; Subject Term: WEB-based user interfaces; Author-Supplied Keyword: food safety; Author-Supplied Keyword: risk; Author-Supplied Keyword: risk ranking; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 2 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1111/j.1750-3841.2008.01042.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36938664&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Webb, Kristen M.
AU - Allard, Marc W.
T1 - Mitochondrial Genome DNA Analysis of the Domestic Dog: Identifying Informative SNPs Outside of the Control Region.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2009/03//
VL - 54
IS - 2
M3 - Article
SP - 275
EP - 288
SN - 00221198
AB - While the mitochondrial control region has proven successful for human forensic evaluations by indicating ethnic origin, domestic dogs ( Canis lupus familiaris) of seemingly unrelated breeds often form large groups based on identical control region sequences. In an attempt to break up these large haplotype groups, we have analyzed the remaining c. 15,484 base pairs of the canine mitochondrial genome for 79 dogs and used phylogenetic and population genetic methods to search for additional variability in the form of single nucleotide polymorphisms (SNPs). We have identified 356 SNPs and 65 haplotypes in the remainder of the mitochondrial genome excluding the control region. The exclusion capacity was found to be 0.018. The mitochondrial control region was also evaluated for the same 79 dogs. The signals from the different fragments do not conflict, but instead support one another and provide a larger fragment of DNA that can be analyzed as forensic evidence. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Forensic Sciences (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOMESTIC animals
KW - DOGS
KW - MITOCHONDRIAL DNA
KW - ANIMAL breeds
KW - MITOCHONDRIA
KW - GENETIC polymorphisms
KW - NUCLEOTIDES
KW - EVALUATION
KW - POPULATION
KW - canine
KW - control region
KW - forensic science
KW - haplogroup
KW - haplotype
KW - mitochondrial genome
KW - SNP
N1 - Accession Number: 36622386; Webb, Kristen M. 1 Allard, Marc W. 2; Affiliation: 1: Animal Parasitic Diseases Laboratory, Agricultural Research Service, United States Department of Agriculture Building 1180, Beltsville, MD 20705. 2: Molecular Methods and Subtyping Branch, Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740-3835.; Source Info: Mar2009, Vol. 54 Issue 2, p275; Subject Term: DOMESTIC animals; Subject Term: DOGS; Subject Term: MITOCHONDRIAL DNA; Subject Term: ANIMAL breeds; Subject Term: MITOCHONDRIA; Subject Term: GENETIC polymorphisms; Subject Term: NUCLEOTIDES; Subject Term: EVALUATION; Subject Term: POPULATION; Author-Supplied Keyword: canine; Author-Supplied Keyword: control region; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: haplogroup; Author-Supplied Keyword: haplotype; Author-Supplied Keyword: mitochondrial genome; Author-Supplied Keyword: SNP; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 14p; Illustrations: 1 Diagram, 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1556-4029.2008.00952.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36622386&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Webb, Kristen M.
AU - Allard, Marc W.
T1 - Identification of Forensically Informative SNPs in the Domestic Dog Mitochondrial Control Region.
JO - Journal of Forensic Sciences (Wiley-Blackwell)
JF - Journal of Forensic Sciences (Wiley-Blackwell)
Y1 - 2009/03//
VL - 54
IS - 2
M3 - Article
SP - 289
EP - 304
SN - 00221198
AB - Dog hair is often found at crime scenes either due to the dog’s involvement in the crime or secondary transfer. As little nuclear DNA is present in shed hair, a 1000 base pair fragment of the mitochondrial control region (mtCR) from 552 dogs was assessed for forensically useful sequence variation. Through pairwise alignment to a standard reference sequence, existing haplotypes were further described and 36 new haplotypes and 24 new single nucleotide polymorphisms were identified. The probability of exclusion was found to be 0.957. Breeds were found to have similar sequences, although not identical. No genetic basis was found for grouping dogs by either purebred or mixed or geographic location within the continental United States. Our research demonstrates that the domestic dog mtCR has not been thoroughly surveyed for sequence variation and that a single database comprised of purebred and mixed breed dogs is sufficient for the continental United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Forensic Sciences (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOGS
KW - HAIR
KW - MITOCHONDRIA
KW - ANIMAL breeds
KW - DNA
KW - GENETIC polymorphisms
KW - NUCLEOTIDES
KW - SURVEYS
KW - UNITED States
KW - control region
KW - domestic dog
KW - forensic science
KW - haplotype
KW - mitochondrial genome
KW - single nucleotide polymorphism
N1 - Accession Number: 36622385; Webb, Kristen M. 1 Allard, Marc W. 2; Affiliation: 1: Animal Parasitic Diseases Laboratory, Agricultural Research Service, United States Department of Agriculture Building 1180, Beltsville, MD 20705. 2: Molecular Methods and Subtyping Branch, Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740-3835.; Source Info: Mar2009, Vol. 54 Issue 2, p289; Subject Term: DOGS; Subject Term: HAIR; Subject Term: MITOCHONDRIA; Subject Term: ANIMAL breeds; Subject Term: DNA; Subject Term: GENETIC polymorphisms; Subject Term: NUCLEOTIDES; Subject Term: SURVEYS; Subject Term: UNITED States; Author-Supplied Keyword: control region; Author-Supplied Keyword: domestic dog; Author-Supplied Keyword: forensic science; Author-Supplied Keyword: haplotype; Author-Supplied Keyword: mitochondrial genome; Author-Supplied Keyword: single nucleotide polymorphism; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 16p; Illustrations: 2 Diagrams, 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1556-4029.2008.00953.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36622385&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kreider, Brent
AU - Hill, Steven C.
T1 - Partially Identifying Treatment Effects with an Application to Covering the Uninsured.
JO - Journal of Human Resources
JF - Journal of Human Resources
Y1 - 2009///Spring2009
VL - 44
IS - 2
M3 - Article
SP - 409
EP - 449
PB - University of Wisconsin Press
SN - 0022166X
AB - We extend the nonparametric literature on partially identified probability distributions and use our analytical results to provide sharp bounds on the impact of universal health insurance on provider visits and medical expenditures. Our approach accounts for uncertainty about the reliability of self-reported insurance status as well as uncertainty created by unknown counterfactuals. We construct health insurance validation data using detailed information from the Medical Expenditure Panel Survey. Imposing relatively weak nonparametric assumptions, we estimate that under universal coverage monthly per capita provider visits and expenditures would rise by less than 8 percent and 16 percent, respectively, across the nonelderly population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Human Resources is the property of University of Wisconsin Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - MEDICALLY uninsured persons
KW - MEDICAL care
KW - PUBLIC spending
KW - LABOR supply
KW - PUBLIC welfare
KW - NATIONAL health insurance
KW - EXOGENEITY (Econometrics)
KW - COUNTERFACTUALS (Logic)
KW - PANEL analysis
KW - FAMILY relations
KW - ELIGIBILITY (Social aspects)
N1 - Accession Number: 38707320; Kreider, Brent 1; Hill, Steven C. 2; Email Address: shill@ahrq.gov; Affiliations: 1: Associate professor of economics, Iowa State University; 2: Senior economist, Center for Financing, Access and Cost Trends (CFACT) of the Agency for Healthcare Research and Quality (AHRQ); Issue Info: Spring2009, Vol. 44 Issue 2, p409; Thesaurus Term: HEALTH insurance; Thesaurus Term: MEDICALLY uninsured persons; Thesaurus Term: MEDICAL care; Thesaurus Term: PUBLIC spending; Thesaurus Term: LABOR supply; Thesaurus Term: PUBLIC welfare; Thesaurus Term: NATIONAL health insurance; Thesaurus Term: EXOGENEITY (Econometrics); Subject Term: COUNTERFACTUALS (Logic); Subject Term: PANEL analysis; Subject Term: FAMILY relations; Subject Term: ELIGIBILITY (Social aspects); NAICS/Industry Codes: 921130 Public Finance Activities; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 561320 Temporary Help Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 624190 Other Individual and Family Services; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; Number of Pages: 41p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Piccotti, Joseph R.
AU - Lebrec, Herve N.
AU - Evans, Ellen
AU - Herzyk, Danuta J.
AU - Hastings, Kenneth L.
AU - Burns-Naas, Leigh Ann
AU - Gourley, Ian S.
AU - Wierda, Daniel
AU - Kawabata, Thomas T.
T1 - Summary of a workshop on nonclinical and clinical immunotoxicity assessment of immunomodulatory drugs.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2009/03//
VL - 6
IS - 1
M3 - Article
SP - 1
EP - 10
PB - Taylor & Francis Ltd
SN - 1547691X
AB - The number of anti-inflammatory and immunomodulatory drugs being developed in the pharmaceutical industry has increased considerably in the past decade. This increase in research and development has been paralleled by questions from both regulatory agencies and industry on how best to assess decreased host resistance to infections or adverse immunostimulation caused by immunomodulatory agents such as anti-cytokine antibodies (e.g., the tumor necrosis factor-α inhibitors), anti-adhesion molecule antibodies (e.g., anti-α-4 integrin inhibitors) and immunostimulatory molecules (e.g., anti-CD28 antibodies). Although several methods have been developed for nonclinical assessment of immunotoxicity, highly publicized adverse events have brought to light significant gaps in the application of nonclinical immunotoxicity testing in assessing potential risk in humans. Confounding this problem is inconsistent application of immunotoxicology methods for risk assessment within the scientific community, limited understanding of appropriate immunotoxicity testing strategy for immunomodulators and inconsistent testing requests by regulatory agencies. To address these concerns, The Immunotoxicology Technical Committee (ITC) of the International Life Science Institute (ILSI) Health and Environmental Sciences Institute (HESI) organized a workshop on Immunomodulators and Clinical Immunotoxicology in May 2007. The Workshop was convened to identify key gaps in nonclinical and clinical immunotoxicity testing of anti-inflammatory and immunomodulatory agents and to begin to develop consistent approaches for immunotoxicity testing and risk assessment. This paper summarizes the outcome of the HESI ITC Immunomodulators and Clinical Immunotoxicology Workshop. Topics not discussed at the Workshop were outside the scope of this report. Although more work is needed to develop consistent approaches for immunotoxicity assessment of immunomodulators, this Workshop provided the foundation for future discussion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Drugs
KW - Immunotoxicology
KW - Immunoglobulins
KW - Anti-inflammatory agents
KW - Tumor necrosis factor
KW - anti-inflammatory
KW - Immunomodulators
KW - immunotoxicity
KW - ITC
KW - Workshop
N1 - Accession Number: 43448244; Piccotti, Joseph R. 1; Email Address: joseph.piccotti@spcorp.com; Lebrec, Herve N. 2; Evans, Ellen 3; Herzyk, Danuta J. 4; Hastings, Kenneth L. 5; Burns-Naas, Leigh Ann 6; Gourley, Ian S. 7; Wierda, Daniel 8; Kawabata, Thomas T. 6; Affiliations: 1: Drug Safety, Schering-Plough Research Institute, Summit and Lafayette, New Jersey, USA; 2: Toxicology, Amgen Inc., Seattle, Washington, USA; 3: `Drug Safety, Schering-Plough Research Institute, Summit and Lafayette, New Jersey, USA; 4: Department of Safety Assessment, Merck & Co Inc., West Point, Pennsylvania, USA; 5: Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Springs, Maryland, USA; 6: Drug Safety Research & Development, Pfizer Global Research & Development, San Diego, California and Groton, Connecticut, USA; 7: Early Development and Clinical Pharmacology, Wyeth Research, Collegeville, Pennsylvania, USA; 8: Immunotoxicology, Eli Lily & Company, Greenfield, Indiana, USA; Issue Info: Mar2009, Vol. 6 Issue 1, p1; Thesaurus Term: Drugs; Subject Term: Immunotoxicology; Subject Term: Immunoglobulins; Subject Term: Anti-inflammatory agents; Subject Term: Tumor necrosis factor; Author-Supplied Keyword: anti-inflammatory; Author-Supplied Keyword: Immunomodulators; Author-Supplied Keyword: immunotoxicity; Author-Supplied Keyword: ITC; Author-Supplied Keyword: Workshop; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 10p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/15476910802656440
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Anderson, Stacey E.
AU - Brown, Kenneth K.
AU - Butterworth, Leon F.
AU - Fedorowicz, Adam
AU - Jackson, Laurel G.
AU - Frasch, H. Fred
AU - Beezhold, Don
AU - Munson, Albert E.
AU - Meade, B. J.
T1 - Evaluation of irritancy and sensitization potential of metalworking fluid mixtures and components.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2009/03//
VL - 6
IS - 1
M3 - Article
SP - 19
EP - 29
PB - Taylor & Francis Ltd
SN - 1547691X
AB - There are approximately 1.2 million workers exposed to metalworking fluids (MWF), which are used to reduce the heat and friction associated with industrial machining and grinding operations. Irritancy and sensitization potential of 9 National Toxicology Program (NTP) nominated MWFs (TRIM 229, TRIM VX, TRIM SC210, CIMTECH 310, CIMPERIAL 1070, CIMSTAR 3800, SYNTILO 1023, SUPEREDGE 6768, and CLEAREDGE 6584) were examined in a combined local lymph node assay (LLNA). BALB/c mice were dermally exposed to each MWF at concentrations up to 50%. Significant irritation was observed after dermal exposure to all MWFs except CIMTECH 310 and SYNTILO 1023. Of the 9 MWFs, 6 induced greater than a 3-fold increase in lymphocyte proliferation and 7 tested positive in the irritancy assay. TRIM VX yielded the lowest EC3 value (6.9%) with respect to lymphocyte proliferation. Chemical components of TRIM VX identified using HPLC were screened for sensitization potential using structural activity relationship (SAR) modeling and the LLNA. TOPKAT predicted triethanolamine (TEA) as a sensitizer while Derek for Windows predicted only 4-chloro-3-methylphenol (CMP) to be positive for sensitization. When tested in the LLNA only CMP (EC3 = 11.6%) and oleic acid (OA) (EC3 = 29.7%) were identified as sensitizers. Exposure to all tested TRIM VX components resulted in statistically significant irritation. An additive proliferative response was observed when mixtures of the two identified sensitizing TRIM VX components, OA and CMP, were tested in the LLNA. This is one explanation of why the EC3 value of TRIM VX, with respect to lymphocyte proliferation, is lower than those assigned to its sensitizing components. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Allergy
KW - Fluid mechanics
KW - Machining
KW - Metalworking industries
KW - Skin -- Inflammation
KW - contact dermatitis
KW - irritancy
KW - LLNA
KW - metalworking fluids
N1 - Accession Number: 43448240; Anderson, Stacey E. 1; Email Address: sanderson4@cdc.gov; Brown, Kenneth K. 2; Butterworth, Leon F. 1; Fedorowicz, Adam 1; Jackson, Laurel G. 1; Frasch, H. Fred 1; Beezhold, Don 1; Munson, Albert E. 1; Meade, B. J. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; Issue Info: Mar2009, Vol. 6 Issue 1, p19; Thesaurus Term: Allergy; Subject Term: Fluid mechanics; Subject Term: Machining; Subject Term: Metalworking industries; Subject Term: Skin -- Inflammation; Author-Supplied Keyword: contact dermatitis; Author-Supplied Keyword: irritancy; Author-Supplied Keyword: LLNA; Author-Supplied Keyword: metalworking fluids; NAICS/Industry Codes: 423510 Metal Service Centers and Other Metal Merchant Wholesalers; Number of Pages: 11p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15476910802604291
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43448240&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shih-Houng Young
AU - Roberts, Jenny R.
AU - Castranova, Vincent
AU - Antonini, James M.
T1 - The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2009/03//
VL - 6
IS - 1
M3 - Article
SP - 49
EP - 61
PB - Taylor & Francis Ltd
SN - 1547691X
AB - The soluble metal fraction of residual oil fly ash (ROFA) has been shown to increase the susceptibility to infection in animal models. The goal of this study was to determine which of the primary soluble metals or metal combinations in ROFA were responsible for the increased infectivity. The soluble fraction of ROFA contained Ni, Fe, Al, and Zn. On Day 0, Sprague-Dawley rats were intratracheally (IT) instilled with NiCl2 (55.7 μg/rat), FeSO4 (32.7 μg/rat), Al3(SO4)2 (46.6 μg/rat), or ZnCl2 (8.69 μg/rat), or a combination of all the metals (Total Mixture). In a separate experiment, rats were instilled with metal mixtures, including the total mixture, and mixtures without Fe (Mix – No Fe), Ni (Mix - No Ni), Al (Mix – No Al), or Zn (Mix - No Zn). At Day 3, rats were instilled with 5 × 104 Listeria monocytogenes. At Days 6, 8 and 10, left lungs were removed to assess bacterial clearance. Bronchoalveolar lavage (BAL) was performed on right lungs on Day 3, before infection, and on Days 6, 8 and 10 to assess lung injury and cellular activity. Prior to infection, soluble Ni and mixtures containing Ni significantly increased lung injury, inflammation, and oxidative damage to a comparable degree when compared to control. Post-infection, rats pre-treated with soluble Ni, alone or in a metal mixture, had increased bacterial lung burden on Day 6, and body weight decreased in the soluble Ni, Mix - No Fe, and Mix - No Al groups post-infection, indicating Fe and Al may act antagonistically to Ni. Ni alone and in metal mixtures increased reactive oxidants in the lung and appeared to be the most important factor in suppressing T-cell activity post-infection. Soluble Ni is likely the primary metal involved in the increased susceptibility to infection observed in rats exposed to the soluble metals of ROFA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fly ash
KW - Nickel compounds
KW - Mice as laboratory animals
KW - Lungs
KW - Listeria monocytogenes
KW - Immunotoxicology
KW - fly ash
KW - immunotoxicology
KW - lung
KW - nickel compounds
N1 - Accession Number: 43448239; Shih-Houng Young 1; Roberts, Jenny R. 1; Email Address: jur6@cdc.gov; Castranova, Vincent 1; Antonini, James M. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, West Virginia, USA; Issue Info: Mar2009, Vol. 6 Issue 1, p49; Thesaurus Term: Fly ash; Thesaurus Term: Nickel compounds; Subject Term: Mice as laboratory animals; Subject Term: Lungs; Subject Term: Listeria monocytogenes; Subject Term: Immunotoxicology; Author-Supplied Keyword: fly ash; Author-Supplied Keyword: immunotoxicology; Author-Supplied Keyword: lung; Author-Supplied Keyword: nickel compounds; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 13p; Illustrations: 5 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/15476910802630379
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43448239&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Baek, Songjoon
AU - Kweon, Ohgew
AU - Kim, Seong-Jae
AU - Baek, Dong-Heon
AU - Chen, James J.
AU - Cerniglia, Carl E.
T1 - ClassRHO: A platform for classification of bacterial rieske non-heme iron ring-hydroxylating oxygenases
JO - Journal of Microbiological Methods
JF - Journal of Microbiological Methods
Y1 - 2009/03//
VL - 76
IS - 3
M3 - Article
SP - 307
EP - 309
SN - 01677012
AB - Abstract: We have developed an easy-to-use multiplatform classification tool, ClassRHO, which facilitates classification and comparison of bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs). Visualization and analysis can be generated on-the-fly by entering or uploading RHO query sequences. Pre-computed classifications were implemented for 42 standard RHO sequences. These 42 RHO sequences can be flexibly selected based on user requests. ClassRHO provides users with many options to view and analyze RHO sequences. [Copyright &y& Elsevier]
AB - Copyright of Journal of Microbiological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACTERIA -- Cytochemistry
KW - IRON-sulfur proteins
KW - OXYGENASES
KW - HYDROXYLATION
KW - AROMATIC compounds
KW - VISUALIZATION
KW - ENZYMES -- Analysis
KW - AMINO acid sequence
KW - Classification
KW - PD matrix
KW - RHO
KW - Sequence alignment
N1 - Accession Number: 36563628; Baek, Songjoon 1 Kweon, Ohgew 2 Kim, Seong-Jae 2 Baek, Dong-Heon 3 Chen, James J. 1; Email Address: jamesJ.chen@fda.hhs.gov Cerniglia, Carl E. 2; Email Address: carl.cerniglia@fda.hhs.gov; Affiliation: 1: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 3: Department of Oral Microbiology and Immunology, School of Dentistry, Dankook University, Chonan 330-714, Republic of Korea; Source Info: Mar2009, Vol. 76 Issue 3, p307; Subject Term: BACTERIA -- Cytochemistry; Subject Term: IRON-sulfur proteins; Subject Term: OXYGENASES; Subject Term: HYDROXYLATION; Subject Term: AROMATIC compounds; Subject Term: VISUALIZATION; Subject Term: ENZYMES -- Analysis; Subject Term: AMINO acid sequence; Author-Supplied Keyword: Classification; Author-Supplied Keyword: PD matrix; Author-Supplied Keyword: RHO; Author-Supplied Keyword: Sequence alignment; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.mimet.2008.11.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36563628&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Geraci, Charles L.
AU - Schubauer-Berigan, Mary K.
AU - Zumwalde, Ralph
AU - Mayweather, Candis
AU - McKernan, John L.
T1 - Issues in the Development of Epidemiologic Studies of Workers Exposed to Engineered Nanoparticles.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2009/03//
VL - 51
IS - 3
M3 - Article
SP - 323
EP - 335
SN - 10762752
AB - The article presents a study which tackles the issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles in the U.S. The researchers reviewed the published literature on incidental and engineered nanoparticles and air pollution to identify such issues in the development of epidemiologic studies of employees exposed to these nanoparticles. It was concluded that consideration of such issues offers the foundation for initiating epidemiological research on workers exposed to engineered nanoparticles.
KW - EPIDEMIOLOGY -- Research
KW - NANOPARTICLES
KW - AIR pollution
KW - PUBLISHERS & publishing -- Officials & employees
KW - PERSONNEL management
KW - INDUSTRIAL management
KW - PUBLIC health
KW - INDUSTRIAL safety
KW - UNITED States
N1 - Accession Number: 37145388; Schulte, Paul A. 1,2; Email Address: PSchulte@cdc.gov Geraci, Charles L. 1,2 Schubauer-Berigan, Mary K. 1,3 Zumwalde, Ralph 1,2 Mayweather, Candis 4 McKernan, John L. 1,3; Affiliation: 1: Centers for Disease Control and Prevention 2: Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 3: National Institute for Occupational Safety and Health, Education and Information Division 4: Rollins School of Public Health, Emory University, Atlanta, Ga; Source Info: Mar2009, Vol. 51 Issue 3, p323; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: NANOPARTICLES; Subject Term: AIR pollution; Subject Term: PUBLISHERS & publishing -- Officials & employees; Subject Term: PERSONNEL management; Subject Term: INDUSTRIAL management; Subject Term: PUBLIC health; Subject Term: INDUSTRIAL safety; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 541612 Human Resources Consulting Services; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 511199 All Other Publishers; NAICS/Industry Codes: 511190 Other publishers; NAICS/Industry Codes: 511130 Book Publishers; Number of Pages: 13p; Illustrations: 3 Diagrams, 2 Graphs; Document Type: Article
L3 - 10.1097/JOM.0b013e3181990c2c
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37145388&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105488544
T1 - Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles.
AU - Schulte PA
AU - Schubauer-Berigan MK
AU - Mayweather C
AU - Geraci CL
AU - Zumwalde R
AU - McKernan JL
Y1 - 2009/03//
N1 - Accession Number: 105488544. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Nanotechnology
KW - Occupational Exposure
KW - Biological Markers
KW - Consent
KW - Disease Surveillance
KW - Education, Continuing (Credit)
KW - Epidemiological Research -- Trends
KW - Privacy and Confidentiality
KW - Registries, Disease
KW - Research Subjects
SP - 323
EP - 335
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 51
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Capitalizing on phenomena at the nanoscale may present great benefits to society. Nevertheless, until the hazards and risks of engineered nanoparticles are determined, the technological products and advances of nanotechnology may be impeded by the societal concerns. Although animal data provide the necessary first step in hazard and risk assessment, ultimately epidemiological studies will be required, especially studies of workers exposed to engineered nanoparticles. It may be too soon to conduct informative epidemiological studies but it is now appropriate to identify issues that will be pertinent and prepare strategies to address them. METHODS: The published scientific literature on incidental and engineered nanoparticles and air pollution were reviewed to identify issues in the conduct of epidemiological studies of workers exposed to engineered nanoparticles. RESULTS: Twelve important issues were identified-the most critical pertaining to particle heterogeneity, temporal factors, exposure characterization, disease endpoints, and identification of the study population. CONCLUSION: Consideration of these issues provides the foundation for initiating epidemiologic research on workers exposed to engineered nanoparticles.
SN - 1076-2752
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. PSchulte@cdc.gov
U2 - PMID: 19225418.
DO - 10.1097/JOM.0b013e3181990c2c
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105488544&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109850557
T1 - New patient safety organizations can help health providers learn from and reduce patient safety events.
AU - Clancy CM
Y1 - 2009/03//2009 Mar
N1 - Accession Number: 109850557. Language: English. Entry Date: 20090515. Revision Date: 20151008. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Patient Safety; Quality Assurance. NLM UID: 101233393.
KW - Organizations -- Standards
KW - Patient Safety
KW - Practice Guidelines
KW - Adverse Health Care Event -- Prevention and Control
KW - Institute of Medicine (U.S.)
KW - Liability, Legal
KW - Patient Advocacy
KW - Privacy and Confidentiality
KW - Provider-Sponsored Organizations
KW - Quality Improvement
KW - United States Department of Health and Human Services
SP - 1
EP - 2
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 5
IS - 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1549-8417
AD - Director of the Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, Maryland 20850 (e-mail: carolyn.clancy(d ahrq.hhs.gov).
U2 - PMID: 19920431.
DO - 10.1097/PTS.0b013e318198dca3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109850557&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Martinez, Marilyn N.
AU - Papich, Mark G.
T1 - Factors influencing the gastric residence of dosage forms in dogs.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2009/03//
VL - 98
IS - 3
M3 - Article
SP - 844
EP - 860
SN - 00223549
AB - An appreciation of the variables influencing canine gastric transit time is of interest both because of the push to develop pharmaceutical products that meet the therapeutic needs of the veterinary patient and because of efforts to improve our understanding of the strengths and weaknesses associated with the use of the dog as a preclinical model to support human product development. The gastric transit time of monogastric species is influenced by many factors. Physiological variables include the time of dosing relative to the phase of the interdigestive migrating myoelectric current (IMMC), the sieving properties of the pylorus, the presence or absence of food, and the inherent crushing force of the stomach. Pharmacological factors include particle size, shape and density, drug solubility, and the hardness of the tablet. Despite the importance of understanding the factors influencing gastric residence time in dogs, an in-depth examination of currently available information on this topic has not as yet been published. Therefore, this review provides an examination of each of these factors and their potential impact on canine oral drug absorption characteristics. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:844–860, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - SPHINCTERS
KW - ABSORPTION
KW - DOGS
KW - bioavailability
KW - food effects
KW - gastrointestinal transit
KW - oral absorption
KW - preclinical pharmacology
KW - AMERICAN Pharmacists Association
N1 - Accession Number: 36341724; Martinez, Marilyn N. 1; Email Address: marilyn.martinez@fda.hhs.gov Papich, Mark G. 2; Affiliation: 1: US Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, 7500 Standish Place, Rockville, Maryland 20855 2: Department of Anatomy, College of Veterinary Medicine, North Carolina State University, Physiological Sciences & Radiology, 4700 Hillsborough Street, Raleigh, North Carolina 27606; Source Info: Mar2009, Vol. 98 Issue 3, p844; Subject Term: PHARMACEUTICAL industry; Subject Term: SPHINCTERS; Subject Term: ABSORPTION; Subject Term: DOGS; Author-Supplied Keyword: bioavailability; Author-Supplied Keyword: food effects; Author-Supplied Keyword: gastrointestinal transit; Author-Supplied Keyword: oral absorption; Author-Supplied Keyword: preclinical pharmacology; Company/Entity: AMERICAN Pharmacists Association; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 17p; Illustrations: 2 Diagrams, 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.1002/jps.21499
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36341724&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Zhiwei
T1 - Likelihood-based confidence sets for partially identified parameters
JO - Journal of Statistical Planning & Inference
JF - Journal of Statistical Planning & Inference
Y1 - 2009/03//
VL - 139
IS - 3
M3 - Article
SP - 696
EP - 710
SN - 03783758
AB - Abstract: There has been growing interest in partial identification of probability distributions and parameters. This paper considers statistical inference on parameters that are partially identified because data are incompletely observed, due to nonresponse or censoring, for instance. A method based on likelihood ratios is proposed for constructing confidence sets for partially identified parameters. The method can be used to estimate a proportion or a mean in the presence of missing data, without assuming missing-at-random or modeling the missing-data mechanism. It can also be used to estimate a survival probability with censored data without assuming independent censoring or modeling the censoring mechanism. A version of the verification bias problem is studied as well. [Copyright &y& Elsevier]
AB - Copyright of Journal of Statistical Planning & Inference is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MISSING data (Statistics)
KW - PARAMETER estimation
KW - DISTRIBUTION (Probability theory)
KW - MATHEMATICAL models
KW - INFERENCE (Logic)
KW - MATHEMATICAL statistics
KW - Censoring
KW - Confidence set
KW - Likelihood
KW - Missing data
KW - Partial identification
KW - Verification bias
N1 - Accession Number: 35559585; Zhang, Zhiwei 1; Email Address: zhiwei.zhang@fda.hhs.gov; Affiliation: 1: Division of Biostatistics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, HFZ-550, Rockville, MD 20850, USA 1; Source Info: Mar2009, Vol. 139 Issue 3, p696; Subject Term: MISSING data (Statistics); Subject Term: PARAMETER estimation; Subject Term: DISTRIBUTION (Probability theory); Subject Term: MATHEMATICAL models; Subject Term: INFERENCE (Logic); Subject Term: MATHEMATICAL statistics; Author-Supplied Keyword: Censoring; Author-Supplied Keyword: Confidence set; Author-Supplied Keyword: Likelihood; Author-Supplied Keyword: Missing data; Author-Supplied Keyword: Partial identification; Author-Supplied Keyword: Verification bias; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.jspi.2007.08.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=35559585&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105478217
T1 - Pharmacists emerge as key stakeholders in quality, patient safety efforts.
AU - Kelly CY
AU - Clancy CM
Y1 - 2009/03//Mar/Apr2009
N1 - Accession Number: 105478217. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101176252.
KW - Pharmacists -- Standards
KW - Pharmacy Service -- Standards
KW - Quality of Health Care
KW - Medicare
KW - Medication Errors -- Prevention and Control
KW - Pharmacists -- Trends
KW - Pharmacy Service -- Economics
KW - Pharmacy Service -- Trends
KW - United States
SP - 146
EP - 150
JO - Journal of the American Pharmacists Association: JAPhA
JF - Journal of the American Pharmacists Association: JAPhA
JA - J AM PHARM ASSOC
VL - 49
IS - 2
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1544-3191
AD - Agency for Healthcare Research and Quality, Rockville, MD, USA. carmen.kelly@ahrq.hhs.gov
U2 - PMID: 19289338.
DO - 10.1331/JAPhA.2009.08171
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105478217&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chen, Yi-Hau
AU - Chatterjee, Nilanjan
AU - Carroll, Raymond J.
AD - Institute of Statistical Science, Academia Sinica
AD - National Institute of Health, US Department of Health and Human Services, Rockville, MD
AD - TX A&M U
T1 - Shrinkage Estimators for Robust and Efficient Inference in Haplotype-Based Case-Control Studies
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/03//
VL - 104
IS - 485
SP - 220
EP - 233
SN - 01621459
N1 - Accession Number: 1120336; Publication Type: Journal Article; Update Code: 201008
N2 - Case-control association studies often aim to investigate the role of genes and gene-environment interactions in terms of the underlying haplotypes (i.e., the combinations of alleles at multiple genetic loci along chromosomal regions). The goal of this article is to develop robust but efficient approaches to the estimation of disease odds-ratio parameters associated with haplotypes and haplotype-environment interactions. We consider "shrinkage" estimation techniques that can adaptively relax the model assumptions of Hardy-Weinberg-Equilibrium and gene-environment independence required by recently proposed efficient "retrospective" methods. Our proposal involves first development of a novel retrospective approach to the analysis of case-control data, one that is robust to the nature of the gene-environment distribution in the underlying population. Next, it involves shrinkage of the robust retrospective estimator toward a more precise, but model-dependent, retrospective estimator using novel empirical Bayes and penalized regression techniques. Methods for variance estimation are proposed based on asymptotic theories. Simulations and two data examples illustrate both the robustness and efficiency of the proposed methods.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1120336&site=ehost-live&scope=site
UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - KLOKE, John D.
AU - MCKEAN, Joseph W.
AU - RASHID, M. Mushfiqur
T1 - Rank-Based Estimation and Associated Inferences for Linear Models With Cluster Correlated Errors.
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/03//
VL - 104
IS - 485
M3 - Article
SP - 384
EP - 390
SN - 01621459
AB - R estimators based on the joint ranks (JR) of all the residuals have been developed over the last 20 years for fitting linear models with independently distributed errors. In this article, we extend these estimators to estimating the fixed effects in a linear model with cluster correlated continuous error distributions for general score functions. We discuss the asymptotic theory of the estimators and standard errors of the estimators. For the related mixed model with a single random effect, we discuss robust estimators of the variance components. These are used to obtain Studentized residuals for the JR fit. A real example is discussed, which illustrates the efficiency of the JR analysis over the traditional analysis and the efficiency of a prudent choice of a score function. Simulation studies over situations similar to the example confirm the validity and efficiency of the analysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Statistical Association is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESTIMATION theory
KW - LINEAR models (Statistics)
KW - CLUSTER analysis (Statistics)
KW - ERROR analysis (Mathematics)
KW - CORRELATION (Statistics)
KW - NONPARAMETRIC statistics
KW - DISTRIBUTION (Probability theory)
KW - STANDARD deviations
KW - RANKING (Statistics)
KW - INFERENCE (Logic)
KW - ASYMPTOTIC theory
KW - MEASUREMENT errors
KW - SYMMETRY (Mathematics)
KW - Compound symmetry
KW - Joint rankings
KW - Mixed models
KW - Nonparametric
KW - Rank regression scores
KW - Robust
KW - Wilcoxon procedures
N1 - Accession Number: 37292098; KLOKE, John D. 1; Email Address: john.kloke@bucknell.edu; MCKEAN, Joseph W. 2; Email Address: joseph.mckean@wmich.edu; RASHID, M. Mushfiqur 3; Email Address: mushfiqur.rashid@fda.hhs.gov; Affiliations: 1: Assistant Professor, Department of Mathematics, Bucknell University, Lewisburg, PA 17837; 2: Professor, Department of Statistics, Western Michigan University, Kalamazzo, MI 49008; 3: Mathematical Statistician, Center for Drug Evaluation and Research/FDA, Division of Biometrics IV, Silver Spring, MD 20993-0002; Issue Info: Mar2009, Vol. 104 Issue 485, p384; Thesaurus Term: ESTIMATION theory; Thesaurus Term: LINEAR models (Statistics); Thesaurus Term: CLUSTER analysis (Statistics); Thesaurus Term: ERROR analysis (Mathematics); Thesaurus Term: CORRELATION (Statistics); Thesaurus Term: NONPARAMETRIC statistics; Thesaurus Term: DISTRIBUTION (Probability theory); Thesaurus Term: STANDARD deviations; Subject Term: RANKING (Statistics); Subject Term: INFERENCE (Logic); Subject Term: ASYMPTOTIC theory; Subject Term: MEASUREMENT errors; Subject Term: SYMMETRY (Mathematics); Author-Supplied Keyword: Compound symmetry; Author-Supplied Keyword: Joint rankings; Author-Supplied Keyword: Mixed models; Author-Supplied Keyword: Nonparametric; Author-Supplied Keyword: Rank regression scores; Author-Supplied Keyword: Robust; Author-Supplied Keyword: Wilcoxon procedures; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Il'yasova, Dora
AU - McCarthy, Bridget J.
AU - Erdal, Serap
AU - Shimek, Joanna
AU - Goldstein, Jennifer
AU - Doerge, Daniel R.
AU - Myers, Steven R.
AU - Vineis, Paolo
AU - Wishnok, John S.
AU - Swenberg, James A.
AU - Bigner, Darell D.
AU - Davis, Faith G.
T1 - Human Exposure to Selected Animal Neurocarcinogens: A Biomarker-Based Assessment and Implications for Brain Tumor Epidemiology.
JO - Journal of Toxicology & Environmental Health: Part B
JF - Journal of Toxicology & Environmental Health: Part B
Y1 - 2009/03//
VL - 12
IS - 3
M3 - Article
SP - 175
EP - 187
SN - 10937404
AB - This review is based on the proceedings from the Second Lebow Conference, held in Chicago in 2007. The conference concentrated on developing a framework for innovative studies in the epidemiology of environmental exposures, focusing specifically on the potential relationship with brain tumors. Researchers with different perspectives, including toxicology, pharmacokinetics, and epidemiological exposure assessment, exchanged information and ideas on the use of biomarkers of exposure in molecular epidemiology studies and summarized the current knowledge on methods and approaches for biomarker-based exposure assessment. This report presents the state of science regarding biomarker-based exposure assessment of the four most common neurocarcinogens: acrylamide, 1,3-butadiene, N-nitroso compounds, and polycyclic aromatic hydrocarbons. Importantly, these chemicals are also carcinogenic in other organs; therefore, this discussion is useful for environmental epidemiologists studying all cancer types. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part B is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFERENCES & conventions
KW - EPIDEMIOLOGY -- Congresses
KW - BRAIN tumors
KW - BIOCHEMICAL markers
KW - CARCINOGENESIS
KW - HYDROCARBONS
KW - CHICAGO (Ill.)
KW - ILLINOIS
N1 - Accession Number: 40117692; Il'yasova, Dora 1; Email Address: dora.ilyasova@duke.edu McCarthy, Bridget J. 2 Erdal, Serap 3 Shimek, Joanna 3 Goldstein, Jennifer 4 Doerge, Daniel R. 5 Myers, Steven R. 6 Vineis, Paolo 7 Wishnok, John S. 8 Swenberg, James A. 9 Bigner, Darell D. 10 Davis, Faith G. 2; Affiliation: 1: Preston Robert Tisch Brain Tumor Center at Duke and Department of Community and Family Medicine, Division of Prevention Research, Duke University Medical Center, Durham, North Carolina, USA 2: Division of Epidemiology and Biostatistics, Chicago, Illinois, USA 3: Division of Environmental and Occupational Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA 4: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA 5: National Center for Toxicological Research, U.S. Food and Drug Administration, Division of Biochemical Toxicology, Jefferson, Arkansas, USA 6: Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA 7: Environmental Epidemiology, Imperial College London, London, United Kingdom 8: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 9: Departments of Environment Sciences and Engineering, Nutrition, and Pathology and Laboratory Medicine and Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 10: Department of Pathology, Pediatric Brain Tumor Foundation Institute at Duke, and Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina, USA; Source Info: Mar2009, Vol. 12 Issue 3, p175; Subject Term: CONFERENCES & conventions; Subject Term: EPIDEMIOLOGY -- Congresses; Subject Term: BRAIN tumors; Subject Term: BIOCHEMICAL markers; Subject Term: CARCINOGENESIS; Subject Term: HYDROCARBONS; Subject Term: CHICAGO (Ill.); Subject Term: ILLINOIS; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 13p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/10937400902894152
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40117692&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gualdi-Russo, Emanuela
AU - Zironi, Alessandro
AU - Dallari, Giovanna V.
AU - Toselli, Stefania
T1 - Migration and Health in Italy: A Multiethnic Adult Sample.
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
Y1 - 2009/03//Mar/Apr2009
VL - 16
IS - 2
M3 - Article
SP - 88
EP - 95
SN - 11951982
AB - Background. Immigration to Italy has increased drastically, but there is a paucity of data on the health of these immigrant populations and the need to improve their health care. Therefore, we analyzed a multiethnic immigrant population in Bologna (northern Italy) to identify the risk factors for health. This anthropometric study was part of a multiregional project “Health Assistance and Monitoring for Indigent Italian Citizens and Immigrants” funded by the Italian Ministry of Health. Methods. The sample consisted of 401 adult immigrants from southeastern Europe (Kosovars, Gypsies, or Roma) and four extra European countries (Senegalese, Moroccans, Tunisians, and Pakistanis). Ethnic ancestry was self-reported. Anthropometric (height, weight, and waist circumference) and blood pressure data were collected during the survey. Results. The prevalence of overweight (and obesity) exceeded 50% in Moroccans and Kosovars of both sexes and in male Roma. The ethnic heterogeneity was associated with different patterns of obesity: the highest prevalence of abdominal obesity was in Moroccan and Kosovar women and in male Kosovars and Gypsies. The highest prevalence of hypertension (more than 20%) was in Senegalese, Kosovar, and Gypsy males. Conclusions. Some of the immigrant subsamples had a high prevalence of obesity, which is associated with morbidity. Our findings on the relationships between the anthropometric traits and the blood pressure suggest different cardiovascular disease risk profiles in the ethnic groups (higher for Kosovars and Roma) and an urgent need for preventive measures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Travel Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMIGRATION & immigration
KW - ANTHROPOMETRY
KW - ETHNICITY
KW - HEART diseases
KW - BLOOD pressure
KW - ITALY
N1 - Accession Number: 37138135; Gualdi-Russo, Emanuela Zironi, Alessandro 1 Dallari, Giovanna V. 2 Toselli, Stefania 3; Affiliation: 1: *Department of Biology and Evolution, Ferrara University, Ferrara, Italy 2: Public Health Service Bologna, Bologna, Italy 3: Department of Evolutionistic Experimental Biology, Bologna University, Bologna, Italy; Source Info: Mar/Apr2009, Vol. 16 Issue 2, p88; Subject Term: EMIGRATION & immigration; Subject Term: ANTHROPOMETRY; Subject Term: ETHNICITY; Subject Term: HEART diseases; Subject Term: BLOOD pressure; Subject Term: ITALY; Number of Pages: 8p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1708-8305.2008.00280.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37138135&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Craine, N.
AU - Parry, J.
AU - O'Toole, J.
AU - D'Arcy, S.
AU - Lyons, M.
T1 - Improvingblood-borne viral diagnosis; clinical audit of the uptake of dried blood spot testing offered by a substance misuse service.
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
Y1 - 2009/03//
VL - 16
IS - 3
M3 - Article
SP - 219
EP - 222
PB - Wiley-Blackwell
SN - 13520504
AB - The diagnosis of blood-borne viral infection amongst drug injectors in Wales is limited by a poor uptake of diagnostic testing; recent research suggests that dried blood spot (DBS) sample collection, rather than venepuncture, may improve diagnostic rates. We carried out an audit of the uptake of DBS testing for hepatitis C, hepatitis B and HIV amongst drug injectors attending a substance misuse service (SMS) in the first year of DBS testing being routinely offered to clients (1 May 2007 to 30 April 2008) and compared the uptake to venepuncture testing of SMS clients in the previous year. Uptake of DBS testing for hepatitis C, hepatitis B and HIV was almost six times greater than the uptake of venepuncture testing amongst clients of the SMS in the previous year. The data are consistent with the hypothesis that DBS testing can increase the uptake of blood-borne viral testing amongst current and ex-drug injectors. We accept that part of the almost sixfold increase in diagnostic testing observed in the first year of DBS testing may be due to an increase in awareness amongst drug injectors of testing opportunities and a prioritization of testing by the SMS. Nonetheless the dramatic increase in uptake demonstrates that DBS testing is acceptable to drug injectors and should be subject to more rigorous trials to evaluate its potential impact on diagnosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Viral Hepatitis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUS diseases
KW - INTRAVENOUS drug abusers
KW - VENOUS puncture
KW - BLOODBORNE infections
KW - HEPATITIS C
KW - HEPATITIS B
KW - LIVER diseases
KW - HEPATITIS -- Diagnosis
KW - dried blood spot testing
KW - hepatitis B
KW - hepatitis C
KW - HIV
KW - injecting drug use
N1 - Accession Number: 36460672; Craine, N. 1; Email Address: noel.craine@nphs.wales.nhs.uk Parry, J. 2 O'Toole, J. 3 D'Arcy, S. 1 Lyons, M. 4; Affiliation: 1: National Public Health Service for Wales, Ysbyty Gwynedd, Bangor, Wales 2: Virus Reference Department, Health Protection Agency, Centre for Infections, Colindale, London 3: North West Wales NHS Trust Substance Misuse Service, Star, Gaerwen, Ynys Mon, Wales 4: National Public Health Service for Wales, Temple of Peace and Health, Cardiff, UK; Source Info: Mar2009, Vol. 16 Issue 3, p219; Subject Term: VIRUS diseases; Subject Term: INTRAVENOUS drug abusers; Subject Term: VENOUS puncture; Subject Term: BLOODBORNE infections; Subject Term: HEPATITIS C; Subject Term: HEPATITIS B; Subject Term: LIVER diseases; Subject Term: HEPATITIS -- Diagnosis; Author-Supplied Keyword: dried blood spot testing; Author-Supplied Keyword: hepatitis B; Author-Supplied Keyword: hepatitis C; Author-Supplied Keyword: HIV; Author-Supplied Keyword: injecting drug use; Number of Pages: 4p; Document Type: Article
L3 - 10.1111/j.1365-2893.2008.01061.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36460672&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105462897
T1 - Identification of hospital-acquired catheter-associated urinary tract infections from medicare claims: sensitivity and positive predictive value.
AU - Zhan C
AU - Elixhauser A
AU - Richards CL Jr
AU - Wang Y
AU - Baine WB
AU - Pineau M
AU - Verzier N
AU - Kliman R
AU - Hunt D
Y1 - 2009/03//2009 Mar
N1 - Accession Number: 105462897. Language: English. Entry Date: 20090327. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Audit -- Methods
KW - Current Procedural Terminology
KW - Insurance
KW - International Classification of Diseases
KW - Medicare -- Statistics and Numerical Data
KW - Urinary Tract Infections, Catheter-Related -- Diagnosis
KW - Aged
KW - Aged, 80 and Over
KW - Algorithms
KW - California
KW - Catheters
KW - Catheters -- Utilization
KW - Female
KW - Human
KW - Male
KW - Medical Records -- Classification
KW - New York
KW - Patient Discharge
KW - Predictive Value of Tests
KW - Sensitivity and Specificity
KW - United States
KW - Urinary Catheterization -- Adverse Effects
KW - Urinary Catheterization -- Utilization
KW - Urinary Tract Infections, Catheter-Related -- Economics
KW - Urinary Tract Infections, Catheter-Related -- Epidemiology
SP - 364
EP - 369
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND AND OBJECTIVE: Hospital-acquired catheter-associated urinary tract infection (CAUTI) is one of the first 6 conditions Medicare is targeting to reduce payment associated with hospital-acquired conditions under Congressional mandate. This study was to determine the positive predictive value (PPV) and sensitivity in identifying patients in Medicare claims who had urinary catheterization and who had hospital-acquired CAUTIs. RESEARCH DESIGN: CAUTIs identified by ICD-9-CM codes in Medicare claims were compared with those revealed by medical record abstraction in random samples of Medicare discharges in 2005 to 2006. Hospital discharge abstracts (2005) from the states of New York and California were used to estimate the potential impact of a present-on-admission (POA) indicator on PPV. RESULTS: ICD-9-CM procedure codes for urinary catheterization appeared in only 1.4% of Medicare claims for patients who had urinary catheters. As a proxy, claims with major surgery had a PPV of 75% and sensitivity of 48%, and claims with any surgical procedure had a PPV of 53% and sensitivity of 79% in identifying urinary catheterization. The PPV and sensitivity for identifying hospital-acquired CAUTIs varied, with the PPV at 30% and sensitivity at 65% in claims with major surgery. About 80% of the secondary diagnosis codes indicating UTIs were flagged as POA, suggesting that the addition of POA indicators in Medicare claims would increase PPV up to 86% and sensitivity up to 79% in identifying hospital-acquired CAUTIs. CONCLUSIONS: The validity in identifying urinary catheter use and CAUTIs from Medicare claims is limited, but will be increased substantially upon addition of a POA indicator.
SN - 0025-7079
AD - Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland 20850-6649, USA. czhan@ahrq.hhs.gov
U2 - PMID: 19194330.
DO - 10.1097/MLR.0b013e31818af83d
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mi-Ja Jung
AU - Dong-Hyug Yang
AU - Yong-Kyung Sung
AU - Mi-Jeong Kim
AU - Shin-Jung Kang
AU - Dong-Yeul Kwon
AU - Youngjoo Kwon
T1 - Rapid determination of trace methylmercury in natural crude medicine of animal origin.
JO - Microchimica Acta
JF - Microchimica Acta
Y1 - 2009/03//
VL - 164
IS - 3/4
M3 - Article
SP - 345
EP - 349
SN - 00263672
AB - A rapid and simple method to determine methylmercury in natural crude medicine of animal origin was developed using gas chromatography electron capture detection (GC-ECD). Methylmercury, one of the forms of organomercury in nature, is much more toxic than inorganic and elemental mercury due to its lipid soluble property. The method is based on acidic digestion in hydrochloric acid solution following the extraction with toluene. The following parameters for the determination of methylmercury with GC-ECD were established: limit of detection 2 μg kg−1, limit of quantification 8 μg kg−1, linearity 10–300 ng mL−1, reproducibility as relative standard deviations 11.8%, 10.7% and 1.7% for 300, 150, and 20 ppb solutions, respectively, and recovery 87.1–112.4%. The results on animal-origin natural medicines using the method developed in this study were assured by comparison with those obtained by the method derived for measuring methylmercury in fish. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microchimica Acta is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHYLMERCURY
KW - GAS chromatography
KW - ORGANOMERCURY compounds
KW - ANALYTICAL chemistry
KW - TOLUENE
KW - Capillary gas chromatography electron capture detection
KW - Methylmercury
KW - Natural medicine of animal origin
N1 - Accession Number: 36478689; Mi-Ja Jung 1 Dong-Hyug Yang 2 Yong-Kyung Sung 3 Mi-Jeong Kim 2 Shin-Jung Kang 2 Dong-Yeul Kwon 4 Youngjoo Kwon 1; Email Address: ykwon@ewha.ac.kr; Affiliation: 1: College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750 South Korea 2: Department of Drug Evaluation, Korea Food and Drug Administration, Seoul 122-704 South Korea 3: Korea Pharma Co. Ltd., Seoul 135-080 South Korea 4: Department of Oriental Pharmacy, Wonkwang University, Iksan 570-749 South Korea; Source Info: Mar2009, Vol. 164 Issue 3/4, p345; Subject Term: METHYLMERCURY; Subject Term: GAS chromatography; Subject Term: ORGANOMERCURY compounds; Subject Term: ANALYTICAL chemistry; Subject Term: TOLUENE; Author-Supplied Keyword: Capillary gas chromatography electron capture detection; Author-Supplied Keyword: Methylmercury; Author-Supplied Keyword: Natural medicine of animal origin; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s00604-008-0063-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Krieg, Edward F.
AU - Butler, Mary Ann
T1 - Blood lead, serum homocysteine, and neurobehavioral test performance in the third National Health and Nutrition Examination Survey
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2009/03//
VL - 30
IS - 2
M3 - Article
SP - 281
EP - 289
SN - 0161813X
AB - Abstract: Regression analysis was used to estimate and test for relationships between blood lead, serum folate, red blood cell folate, serum vitamin B12, serum homocysteine, and neurobehavioral test performance in adults, 20–59 years old, participating in the third National Health and Nutrition Examination Survey. The three neurobehavioral tests included in the survey were simple reaction time, symbol–digit substitution, and serial digit learning. Serum folate, red blood cell folate, and serum vitamin B12 decreased as the blood lead concentration increased. Serum homocysteine increased as the blood lead concentration increased. Serum homocysteine decreased as the serum folate and serum vitamin B12 concentrations increased. Neurobehavioral test performance was not related to the blood lead, serum folate, or serum vitamin B12 concentrations. In adults 20–39 years old, performance on the serial digit learning test improved as the serum homocysteine concentration increased. In adults 40–59 years old, neurobehavioral test performance was not related to the serum homocysteine concentration. Homocysteine may impair cognitive function by acting at N-methyl-d-aspartate receptors, and improve cognitive function by acting at N-methyl-d-aspartate or γ-aminobutyric acid receptors. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - BLOOD analysis
KW - HEALTH surveys
KW - HOMOCYSTEINE
KW - SERUM
KW - VITAMIN B12
KW - GABA
KW - ERYTHROCYTES
KW - REACTION time
KW - NEUROTOXICOLOGY
KW - Blood lead
KW - Folate
KW - Homocysteine
KW - Neurobehavioral tests
KW - NHANES III
KW - NMDA
KW - Vitamin B12
N1 - Accession Number: 36969446; Krieg, Edward F.; Email Address: erk3@cdc.gov Butler, Mary Ann 1; Affiliation: 1: National Institute for Occupational Safety and Health, United States; Source Info: Mar2009, Vol. 30 Issue 2, p281; Subject Term: REGRESSION analysis; Subject Term: BLOOD analysis; Subject Term: HEALTH surveys; Subject Term: HOMOCYSTEINE; Subject Term: SERUM; Subject Term: VITAMIN B12; Subject Term: GABA; Subject Term: ERYTHROCYTES; Subject Term: REACTION time; Subject Term: NEUROTOXICOLOGY; Author-Supplied Keyword: Blood lead; Author-Supplied Keyword: Folate; Author-Supplied Keyword: Homocysteine; Author-Supplied Keyword: Neurobehavioral tests; Author-Supplied Keyword: NHANES III; Author-Supplied Keyword: NMDA; Author-Supplied Keyword: Vitamin B12; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.neuro.2008.12.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36969446&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105492484
T1 - Outbreak case reports.
AU - Grey C
AU - Simmons G
AU - Ormsby C
AU - Hewitt J
Y1 - 2009/03//
N1 - Accession Number: 105492484. Language: English. Entry Date: 20090410. Revision Date: 20151015. Publication Type: Journal Article; case study. Journal Subset: Australia & New Zealand; Biomedical; Public Health. Special Interest: Public Health. NLM UID: 101213519.
KW - Disease Outbreaks -- Trends -- New Zealand
KW - Caliciviridae Infections -- Etiology
KW - Disease Vectors
KW - Food Services
KW - Gastroenteritis -- Etiology
KW - Mollusca
KW - New Zealand
SP - 6
EP - 7
JO - New Zealand Public Health Surveillance Report
JF - New Zealand Public Health Surveillance Report
JA - NZ PUBLIC HEALTH SURVEILLANCE REP
VL - 7
IS - 1
PB - Institute of Environmental Science & Research Limited
SN - 1176-2888
AD - Public Health Medicine Registrar, Auckland Regional Public Health Service
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chih-Hsin Liu
T1 - Exertion can disrupt axillofemoral bypass grafts.
JO - Nursing
JF - Nursing
Y1 - 2009/03//
VL - 39
IS - 3
M3 - Article
SP - 63
EP - 63
SN - 03604039
AB - The article discusses axillofemoral bypass graft surgery for occlusive vascular disease and precautions to reduce complications after surgery. It presents an example of prosthetic graft disruption and its consequences. Precautions include checking the label for instructions, making sure its long enough, and teaching patients to refrain from abrupt movement.
KW - VASCULAR grafts
KW - VASCULAR surgery
KW - MEDICAL equipment -- Safety measures
KW - SURGERY
KW - PATIENTS -- Safety measures
N1 - Accession Number: 37134912; Chih-Hsin Liu 1; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health; Source Info: Mar2009, Vol. 39 Issue 3, p63; Subject Term: VASCULAR grafts; Subject Term: VASCULAR surgery; Subject Term: MEDICAL equipment -- Safety measures; Subject Term: SURGERY; Subject Term: PATIENTS -- Safety measures; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; Number of Pages: 2/3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105469771
T1 - Device safety. Exertion can disrupt axillofemoral bypass grafts.
AU - Liu C
Y1 - 2009/03//
N1 - Accession Number: 105469771. Language: English. Entry Date: 20090410. Revision Date: 20150711. Publication Type: Journal Article; brief item; case study; questions and answers. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 7600137.
KW - Blood Vessel Prosthesis -- Adverse Effects
KW - Exertion
KW - Peripheral Vascular Diseases -- Surgery
KW - Postoperative Complications
KW - Prosthesis Failure
KW - Aged
KW - Femoral Artery -- Surgery
KW - Inpatients
KW - Male
KW - Patient Education
SP - 63
EP - 63
JO - Nursing
JF - Nursing
JA - NURSING
VL - 39
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health
U2 - PMID: 19247137.
DO - 10.1097/01.NURSE.0000347087.27578.6e
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105469771&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kavanaugh, Claudine J.
AU - Trumbo, Paula R.
AU - Ellwood, Kathleen C.
T1 - Qualified Health Claims for Calcium and Colorectal, Breast, and Prostate Cancers: The U.S. Food and Drug Administration's Evidence-Based Review.
JO - Nutrition & Cancer
JF - Nutrition & Cancer
Y1 - 2009/03//Mar/Apr2009
VL - 61
IS - 2
M3 - Article
SP - 157
EP - 164
PB - Taylor & Francis Ltd
SN - 01635581
AB - In 2003, the United States Food and Drug Administration (FDA) received a health claim petition for calcium supplements and reduced risk of colorectal, breast, and prostate cancers. Health claims characterize the relationship between a substance (food or food component) and disease (e.g., cancer or cardiovascular disease) or health-related condition (e.g., hypertension) and require premarket approval for the labeling of conventional foods and dietary supplements by the FDA. This review describes how the FDA used the evidence-based review system to evaluate the scientific evidence for these proposed health claims. FDA found no credible evidence to support health claims for calcium and a reduced risk of breast and prostate cancers. The agency did find limited evidence for the relationship between calcium intake and colorectal cancer risk. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROSTATE cancer
KW - PUBLIC health -- United States
KW - DIETARY supplements
KW - FOOD -- Calcium content
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 36592064; Kavanaugh, Claudine J. 1; Email Address: claudine.kavanaugh@fda.hhs.gov Trumbo, Paula R. 1 Ellwood, Kathleen C. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA; Source Info: Mar/Apr2009, Vol. 61 Issue 2, p157; Subject Term: PROSTATE cancer; Subject Term: PUBLIC health -- United States; Subject Term: DIETARY supplements; Subject Term: FOOD -- Calcium content; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/01635580802395741
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36592064&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105470214
T1 - Qualified health claims for calcium and colorectal, breast, and prostate cancers: the U.S. Food and Drug Administration's evidence-based review.
AU - Kavanaugh CJ
AU - Trumbo PR
AU - Ellwood KC
Y1 - 2009/03//Mar/Apr2009
N1 - Accession Number: 105470214. Language: English. Entry Date: 20090522. Revision Date: 20150711. Publication Type: Journal Article; review; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Nutrition; Oncologic Care. NLM UID: 7905040.
KW - Breast Neoplasms -- Prevention and Control
KW - Calcium -- Therapeutic Use
KW - Colonic Neoplasms -- Prevention and Control
KW - Medical Practice, Evidence-Based -- Methods
KW - Prostatic Neoplasms -- Prevention and Control
KW - United States Food and Drug Administration
KW - Apoptosis
KW - Diet
KW - Legislation
KW - Neoplasms -- Diagnosis
KW - Neoplasms -- Risk Factors
KW - Nutrition
SP - 157
EP - 164
JO - Nutrition & Cancer
JF - Nutrition & Cancer
JA - NUTR CANCER
VL - 61
IS - 2
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In 2003, the United States Food and Drug Administration (FDA) received a health claim petition for calcium supplements and reduced risk of colorectal, breast, and prostate cancers. Health claims characterize the relationship between a substance (food or food component) and disease (e.g., cancer or cardiovascular disease) or health-related condition (e.g., hypertension) and require premarket approval for the labeling of conventional foods and dietary supplements by the FDA. This review describes how the FDA used the evidence-based review system to evaluate the scientific evidence for these proposed health claims. FDA found no credible evidence to support health claims for calcium and a reduced risk of breast and prostate cancers. The agency did find limited evidence for the relationship between calcium intake and colorectal cancer risk.
SN - 0163-5581
AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; claudine.kavanaugh@fda.hhs.gov
U2 - PMID: 19235032.
DO - 10.1080/01635580802395741
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105470214&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105484926
T1 - Antenatal testing-a reevaluation: executive summary of a Eunice Kennedy Shriver National Institute of Child Health and Human Development workshop.
AU - Signore C
AU - Freeman RK
AU - Spong CY
AU - Signore, Caroline
AU - Freeman, Roger K
AU - Spong, Catherine Y
Y1 - 2009/03//
N1 - Accession Number: 105484926. Language: English. Entry Date: 20090424. Revision Date: 20161119. Publication Type: journal article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Obstetric Care; Women's Health. Grant Information: Z99 HD999999//Intramural NIH HHS/United States. NLM UID: 0401101.
KW - Fetal Monitoring
KW - Adult
KW - Amniotic Fluid
KW - Blood Circulation
KW - Cardiotocography
KW - Congresses and Conferences
KW - Female
KW - Fetal Growth Retardation -- Physiopathology
KW - National Institutes of Health (U.S.)
KW - Perinatal Death -- Epidemiology
KW - Pregnancy
KW - Pregnancy-Induced Hypertension -- Physiopathology
KW - Ultrasonography, Prenatal
KW - Umbilical Arteries
KW - United States
KW - Uterus -- Blood Supply
SP - 687
EP - 701
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
JA - OBSTET GYNECOL
VL - 113
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - In August 2007, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institutes of Health Office of Rare Diseases, the American College of Obstetricians and Gynecologists, and the American Academy of Pediatrics cosponsored a 2-day workshop to reassess the body of evidence supporting antepartum assessment of fetal well-being, identify key gaps in the evidence, and formulate recommendations for further research. Participants included experts in obstetrics and fetal physiology and representatives from relevant stakeholder groups and organizations. This article is a summary of the discussions at the workshop, including synopses of oral presentations on the epidemiology of stillbirth and fetal neurological injury, fetal physiology, techniques for antenatal monitoring, and maternal and fetal indications for monitoring. Finally, a synthesis of recommendations for further research compiled from three breakout workgroups is presented.
SN - 0029-7844
AD - Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
AD - Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA. signorec@mail.nih.gov
U2 - PMID: 19300336.
DO - 10.1097/AOG.0b013e318197bd8a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105484926&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105512895
T1 - FDA review of a panitumumab (VECTIBIX) clinical trial for first-line treatment of metastatic colorectal cancer.
AU - Giusti RM
AU - Cohen MH
AU - Keegan P
AU - Pazdur R
Y1 - 2009/03//
N1 - Accession Number: 105512895. Language: English. Entry Date: 20090619. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Antibodies, Monoclonal -- Therapeutic Use
KW - Colorectal Neoplasms -- Drug Therapy
KW - Neoplasm Metastasis -- Drug Therapy
KW - Antineoplastic Agents -- Therapeutic Use
KW - Drug Approval
KW - Treatment Outcomes
KW - United States Food and Drug Administration
SP - 284
EP - 290
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 14
IS - 3
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On September 27, 2006, the U.S. Food and Drug Administration granted accelerated approval to panitumumab (Vectibix; Amgen, Inc., Thousand Oaks, CA) for the treatment of patients with epidermal growth factor receptor-expressing, metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Accelerated approval was based on demonstration of a beneficial effect on progression-free survival (PFS). The present submission summarizes a second clinical trial, to be included in the panitumumab package insert in June 2008, of chemotherapy and bevacizumab with and without panitumumab in the first-line treatment of patients with metastatic colorectal cancer. The study was closed when inferior PFS and greater toxicity were demonstrated at the time of the planned interim efficacy analysis. Patients receiving panitumumab in combination with bevacizumab and chemotherapy experienced a higher incidence of death (9% versus 4%) and a higher risk for grade 3 and 4 toxicities than patients receiving bevacizumab and chemotherapy alone. The incidences of any Common Terminology Criteria for Adverse Events grade 3 and 4 adverse events (AEs) were 87% and 72% in the panitumumab and control groups, respectively. Grade 3 and 4 AEs occurring more commonly in panitumumab-treated patients included rash/acneiform dermatitis, diarrhea, dehydration, primarily resulting from diarrhea, hypokalemia, stomatitis/mucositis, and pulmonary embolism. The addition of panitumumab to bevacizumab and chemotherapy for the first-line treatment of metastatic colorectal cancer was harmful when compared with bevacizumab and chemotherapy alone. The use of panitumumab in this setting cannot be recommended.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. ruthann.giusti@fda.hhs.gov
U2 - PMID: 19282350.
DO - 10.1634/theoncologist.2008-0254
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105472517
T1 - Characteristics of children whose siblings have fetal alcohol syndrome or incomplete fetal alcohol syndrome.
AU - Kvigne VL
AU - Leonardson GR
AU - Borzelleca J
AU - Neff-Smith M
AU - Welty TK
Y1 - 2009/03//
N1 - Accession Number: 105472517. Language: English. Entry Date: 20090807. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care; Psychiatry/Psychology. NLM UID: 0376422.
KW - Fetal Alcohol Syndrome
KW - Native Americans -- In Infancy and Childhood
KW - Siblings -- In Infancy and Childhood
KW - Case Control Studies
KW - Chi Square Test
KW - Child
KW - Child Behavior Disorders
KW - Child Development Disorders
KW - Child, Preschool
KW - Confidence Intervals
KW - Developmental Disabilities
KW - Face -- Pathology
KW - Female
KW - Fisher's Exact Test
KW - Hospitalization
KW - Infant
KW - Infant, Newborn
KW - Male
KW - McNemar's Test
KW - Odds Ratio
KW - Random Sample
KW - Record Review
KW - Retrospective Design
KW - T-Tests
KW - Human
SP - e526
EP - 33
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 123
IS - 3
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: To describe the clinical features of American Indian children born just before and just after a sibling with fetal alcohol syndrome or incomplete fetal alcohol syndrome. METHODS: Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome or incomplete fetal alcohol syndrome identified from 1981 to 1993 by using International Classification of Diseases, Ninth Revision, Clinical Modification code 760.71. RESULTS: Compared with the controls, the 39 siblings born just before children with fetal alcohol syndrome (study 1) and 30 siblings born just before children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (23.1% and 16.7%, respectively), growth delay (38.5% and 10.0%), and central nervous system impairment (48.7% and 33.3%). The 20 siblings born just after children with fetal alcohol syndrome (study 1) and 22 siblings born just after children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (20.0% and 9.1%, respectively), growth delay (45.0% and 22.7%), and central nervous system impairment (50.0% and 31.8%) than the control siblings. CONCLUSIONS: The 'before' siblings had characteristics of fetal alcohol syndrome that could have predicted that the next child was at risk for fetal alcohol syndrome. The 'after' siblings had better outcomes than the previous siblings with fetal alcohol syndrome, a finding that was associated with a decrease in maternal alcohol consumption during the after-sibling pregnancy.
SN - 0031-4005
AD - Aberdeen Area Indian Health Service, Aberdeen, South Dakota, USA. kvig6@aol.com
U2 - PMID: 19254987.
DO - 10.1542/peds.2008-2423
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Willy, Mary
AU - Kelly, Judith P.
AU - Nourjah, Parivash
AU - Kaufman, David W.
AU - Budnitz, Daniel S.
AU - Staffa, Judy
T1 - Emergency department visits attributed to selected analgesics, United States, 2004-2005.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/03//
VL - 18
IS - 3
M3 - Article
SP - 188
EP - 195
SN - 10538569
AB - Purpose To estimate the rate of emergency department (ED) visits attributed to selected analgesic-containing medications. Methods We used a nationally representative public health surveillance system to provide estimates of adverse events identified in EDs, and a national telephone survey to provide estimates of selected analgesic-containing medication usage in the US population, 2004-2005. Analysis was restricted to products containing acetaminophen, aspirin, ibuprofen, or naproxen. Types of adverse events and outcomes were compared. Estimated numbers and rates of ED visits were calculated by analgesic groupings and patient age groups. Results The estimated overall rate of ED visits attributed to analgesic-containing medications was 1.6 visits /100 000 users per week. The very old and very young had the highest rates; there were minimal differences in rates by patient gender. Acetaminophen was the attributed drug with the most estimated ED visits and generally had the highest rates of ED visits. The highest estimated rate for a specific product group was among subjects 18-64 years of age taking narcotic-acetaminophen products (8.9 ED visits /100 000 users per week). Overall, 12% of patients presenting to EDs with analgesic-attributed events were hospitalized. Conclusions Rates of ED visits due to analgesics vary depending on the age of the patient and the product; most do not result in hospitalization. Although the rate of emergency visits is relatively low, because of the wide use of the analgesics, public health impact is considerable. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707218; Willy, Mary 1; Kelly, Judith P. 2; Nourjah, Parivash 3; Kaufman, David W. 2; Budnitz, Daniel S. 4; Staffa, Judy 1; Affiliations: 1: Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA; 2: Slone Epidemiology Center at Boston University, Boston, MA, USA; 3: Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA; 4: Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA; Issue Info: Mar2009, Vol. 18 Issue 3, p188; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1691
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Brown, Jeffrey S.
AU - Kulldorff, Martin
AU - Petronis, Kenneth R.
AU - Reynolds, Robert
AU - Chan, K. Arnold
AU - Davis, Robert L.
AU - Graham, David
AU - Andrade, Susan E
AU - Raebel, Marsha A.
AU - Herrinton, Lisa
AU - Roblin, Douglas
AU - Boudreau, Denise
AU - Smith, David
AU - Gurwitz, Jerry H.
AU - Gunter, Margaret J.
AU - Platt, Richard
T1 - Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/03//
VL - 18
IS - 3
M3 - Article
SP - 226
EP - 234
SN - 10538569
AB - Purpose Active surveillance of population-based health networks may improve the timeliness of detection of adverse events (AEs). Our objective was to expand our previous signal detection work by investigating the effect on signal detection of alternative study specifications. Methods We compared the signal detection performance under various study specifications using historical data from nine health plans involved in the HMO Research Network's Center for Education and Research on Therapeutics (CERT). Five drug-event pairs representing generally accepted associations with an AE and two pairs representing 'negative controls' were analyzed. Alternative study specifications related to the definition of incident users and incident AEs were assessed and compared to our previous findings. Results Relaxing the incident AE exclusion criteria by (1) including members with prior outpatient diagnoses of interest and (2) halving (to 90 days) the time window specified to define incident exposure and diagnoses increased the number of members under surveillance and as a consequence increased the number of exposed days and diagnoses by about 10-20%. The alternative specifications tend to result in earlier signal detection by 10-16 months, a likely consequence of more exposures and events entering the analysis. Conclusions This paper provides additional preliminary information related to conducting prospective safety monitoring using health plan data and sequential analytic methods. Our findings support continued investigation of using health plan data and sequential analytic methods as a potentially important contribution to active drug safety surveillance. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707214; Brown, Jeffrey S. 1,2; Kulldorff, Martin 1; Petronis, Kenneth R. 3; Reynolds, Robert 3; Chan, K. Arnold 4,5; Davis, Robert L. 6; Graham, David 7; Andrade, Susan E 2,8; Raebel, Marsha A. 2,9; Herrinton, Lisa 2,10; Roblin, Douglas 2,6; Boudreau, Denise 2,11; Smith, David 2,12; Gurwitz, Jerry H. 2,8; Gunter, Margaret J. 2,13; Platt, Richard 1,2; Affiliations: 1: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA; 2: The HMO Research Network Center for Education and Research in Therapeutics, USA; 3: Pfizer Inc, New York, NY, USA; 4: Harvard School of Public Health, Boston, MA, USA; 5: i3 Drug Safety, Waltham, MA, USA; 6: Kaiser Permanente Georgia, Atlanta GA, USA; 7: Office of Drug Safety, Food and Drug Administration, Rockville, MD, USA; 8: Meyers Primary Care Institute (University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan), Worcester, MA, USA; 9: Kaiser Permanente Colorado, Denver, CO, USA; 10: Kaiser Permanente Northern California, Oakland, CA, USA; 11: Center for Health Studies, Group Health Cooperative, Seattle, WA, USA; 12: Kaiser Permanente Northwest, Portland OR, USA; 13: Lovelace Clinic Foundation, Albuquerque, NM, USA; Issue Info: Mar2009, Vol. 18 Issue 3, p226; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1706
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Andrade, Susan E.
AU - McPhillips, Heather
AU - Loren, David
AU - Raebel, Marsha A.
AU - Lane, Kimberly
AU - Livingston, James
AU - Boudreau, Denise M.
AU - Smith, David H.
AU - Davis, Robert L.
AU - Willy, Mary E.
AU - Platt, Richard
T1 - Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/03//
VL - 18
IS - 3
M3 - Article
SP - 246
EP - 252
SN - 10538569
AB - Purpose To determine the prevalence of persistent pulmonary hypertension of the newborn (PPHN) among infants whose mothers were exposed to antidepressants in the third trimester of pregnancy compared to the prevalence among infants whose mothers were not exposed to antidepressants in the third trimester. Methods A retrospective study was conducted using the automated databases of four health plans participating in the HMO Research Network Center for Education and Research on Therapeutics. Women who delivered an infant in a hospital from 1 January 1996 through 31 December 2000 were identified. The administrative databases were used to identify full-term infants whose mothers received an antidepressant during the third trimester of pregnancy and unexposed infants whose mothers did not receive an antidepressant during the third trimester. Hospitalization data were used to identify diagnoses or procedure codes potentially indicative of PPHN. Results Among 1104 infants exposed to antidepressants in the third trimester and a matched sample of 1104 unexposed infants, five infants were classified by the expert reviewers as having PPHN. Among those infants whose mothers were exposed to selective serotonin reuptake inhibitors (SSRIs) in the third trimester, the prevalence of PPHN was 2.14 per 1000 (95% confidence interval (CI) 0.26, 7.74), while the prevalence among infants whose mothers were not exposed was 2.72 per 1000 (95%CI 0.56, 7.93). Conclusions We did not find an association between SSRI use in late pregnancy and PPHN. Limitations of the present study, including the small number of confirmed cases, suggest further research in this area may be warranted. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707220; Andrade, Susan E. 1,2; McPhillips, Heather 2,3; Loren, David 3; Raebel, Marsha A. 2,4; Lane, Kimberly 2,5; Livingston, James 2,5; Boudreau, Denise M. 2,6; Smith, David H. 2,7; Davis, Robert L. 2,8; Willy, Mary E. 9; Platt, Richard 2,5; Affiliations: 1: Meyers Primary Care Institute, University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan, Worcester, MA, USA; 2: The HMO Research Network Center for Education and Research in Therapeutics, Boston, MA, USA; 3: Department of Pediatrics, University of Washington, Seattle, WA, USA; 4: Kaiser Permanente Colorado, Denver, CO, USA; 5: Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA; 6: Center for Health Studies, Group Health Cooperative, Seattle, WA, USA; 7: Kaiser Permanente Northwest, Portland, OR, USA; 8: Center for Health Research, Kaiser Permanente Southeast, Atlanta, GA, USA; 9: Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Mar2009, Vol. 18 Issue 3, p246; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1710
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105450230
T1 - A message from the editor.
AU - Reed LD
Y1 - 2009/03//Mar/Apr2009
N1 - Accession Number: 105450230. Language: English. Entry Date: 20090508. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Electric Injuries -- Mortality
KW - Firearms
KW - Communications Media
KW - Electric Injuries -- Etiology
KW - Equipment Safety
KW - Relative Risk
KW - Social Control -- Methods
KW - United States
SP - 187
EP - 187
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 124
IS - 2
PB - Sage Publications Inc.
SN - 0033-3549
AD - Captain, U.S. Public Health Service
U2 - PMID: 19320356.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105488378
T1 - Is perceived racial privilege associated with health? Findings from the Behavioral Risk Factor Surveillance System.
AU - Fujishiro K
Y1 - 2009/03//
N1 - Accession Number: 105488378. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Continental Europe; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Special Interest: Social Work. NLM UID: 8303205.
KW - Ethnic Groups -- Statistics and Numerical Data
KW - Health Status
KW - Perception
KW - Prejudice
KW - Whites -- Statistics and Numerical Data
KW - Work Environment
KW - Adolescence
KW - Adult
KW - Aged
KW - Ethnic Groups -- Psychosocial Factors
KW - Female
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Risk Assessment
KW - Sociology
KW - United States
KW - Whites -- Psychosocial Factors
KW - Work Environment -- Psychosocial Factors
KW - Human
SP - 840
EP - 844
JO - Social Science & Medicine
JF - Social Science & Medicine
JA - SOC SCI MED
VL - 68
IS - 5
PB - Pergamon Press - An Imprint of Elsevier Science
AB - While racial discrimination has gained increasing attention in public health research, little is known about perceived racial privilege and health. Using the Behavioral Risk Factor Surveillance System (BRFSS) data, this study explored the relationship of both perceived racial discrimination and privilege with well-being in the USA. Data were extracted from the BRFSS 2004 data set, in which 22,412 respondents in seven states and one major city provided data on perceived racial discrimination and privilege at work. Logistic regression analysis was conducted to examine the relationships of differential racial treatment to self-rated general health status and the number of physically and mentally unhealthy days. Racially stratified analyses found that perceived racial privilege was significantly associated with more days of poor physical and mental health. This relationship was consistent for Whites, but for racial minorities it appeared on only some outcome measures. Reports of being treated worse than other races in the workplace were associated with poor health for all racial groups, as had been reported in previous studies on racial discrimination. Because racial discrimination and racial privilege are both products of racism, this study's findings suggest that racism may harm all involved. Impacts of perceived racial privilege deserve more attention in the literature on racism and health.
SN - 0277-9536
AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation, and Field Studies, 4676 Columbia Parkway (R-17), Cincinnati, Ohio 45226, USA.
U2 - PMID: 19136189.
DO - 10.1016/j.socscimed.2008.12.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105488378&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Labhardt, Niklaus Daniel
AU - Manga, Engelbert
AU - Ndam, Mama
AU - Balo, Jean-Richard
AU - Bischoff, Alexandre
AU - Stoll, Beat
T1 - Early assessment of the implementation of a national programme for the prevention of mother-to-child transmission of HIV in Cameroon and the effects of staff training: a survey in 70 rural health care facilities.
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
Y1 - 2009/03//
VL - 14
IS - 3
M3 - Article
SP - 288
EP - 293
PB - Wiley-Blackwell
SN - 13602276
AB - Objectives To assess the availability of equipment and the staff’s knowledge to prevent Mother-To-Child Transmission (PMTCT) in rural healthcare facilities recently covered by the national PMTCT programme in Cameroon. Methods In eight districts inventories of antiviral drugs and HIV test kits were made on site, using a standardised check-list. Knowledge of HIV and PMTCT was evaluated with a multiple-choice (MC) questionnaire based on typical clinical PMTCT cases. Staff participated subsequently in a 2-day training on HIV/AIDS and the Cameroon PMTCT guidelines. Immediately after training and after 7 months, retention of knowledge was tested with the same questions but in different order and layout. Results Sixty two peripheral nurse-led clinics and the eight district hospitals were assessed. Whereas all district hospitals presented complete equipment, only six of the peripheral clinics (10%) were equipped with both complete testing materials and a full set of drugs to provide PMTCT. Thirty six peripheral facilities (58%) possessed full equipment for HIV-testing and 8 (13%) stocked all PMTCT drugs. Of 137 nurses, 102 (74%) agreed to the two knowledge tests. Fewer than 66% knew that HIV-diagnosis requires positive results in two different types of rapid tests and only 19% chose the right recommendation on infant-feeding for HIV-positive mothers. Correct answers on drug regimens in different PMTCT settings varied from 25% to 56%. All percentages of correct answers improved greatly with training ( P < 0.001) and retention remained high 7 months after training ( P < 0.001). Conclusions Prevent Mother-To-Child Transmission programmes in settings such as rural Cameroon need to be adapted to the special needs of peripheral nurse-led clinics. Appropriate short training may considerably improve nurses’ competence in PMTCT. Other important components are regular supervision and measures to guarantee supply of equipment in rural areas. (English) [ABSTRACT FROM AUTHOR]
AB - Objetivos: Evaluar la disponibilidad del equipamiento y el conocimiento del personal sanitario para la prevención de la transmisión vertical (PTV) en centros sanitarios rurales recientemente cubiertos por el programa nacional de PTV en Camerún. Métodos: Utilizando listas estandarizadas se realizaron inventarios de los medicamentos antirretrovirales y de los kits de pruebas para el VIH en ocho distritos. El conocimiento sobre el VIH y la PTV se evaluó con un cuestionario de escogencia múltiple basado en casos clínicos típicos de PTV. El personal sanitario participó subsecuentemente en un entrenamiento de dos días sobre VIH/SIDA y las guías de PTV del Camerún. Inmediatamente después del entrenamiento y tras siete meses, se evaluó la retención de los conocimientos utilizando las mismas preguntas pero en diferente orden y presentación. Resultados: Se realizó la evaluación a 62 enfermeras de clínicas periféricas y a 8 de hospitales distritales. Mientras que todos los hospitales tenían un equipamiento completo, solo 6 de las clínicas periféricas (10%) estaban completamente equipadas, tanto con los materiales para realizar las pruebas como con los medicamentos para la PTV. 36 de los centros periféricos (58%) tenían el equipo completo para la prueba del VIH y 8 (13%) tenían los medicamentos para la PTV. De las 137 enfermeras, 102 (74%) concordaron en las dos pruebas de conocimientos. Menos del 66% sabía que el diagnóstico del VIH requiere resultados positivos en dos tipos diferentes de tests diagnósticos rápidos y solo un 19% escogió la recomendación adecuada sobre la alimentación del bebé de madre VIH positiva. Las respuestas correctas sobre los regímenes de medicamentos en diferentes centros de prevención de la TV variaron del 25% al 56%. Todos los porcentajes de respuestas correctas aumentaron significativamente con el entrenamiento (p<0.001). Conclusiones: El programa de prevención de la TV en lugares como la zona rural del Camerún deben adaptarse a las necesidades especiales de los centros periféricos liderados por enfermeras. Un entrenamiento corto y adecuado podría mejorar considerablemente las competencias de las enfermeras en la PTV. Otros componentes importantes son la supervisión regular y las medidas para garantizar el suministro de equipamiento a zonas rurales. (Spanish) [ABSTRACT FROM AUTHOR]
AB - Objectifs: Evaluer la disponibilité de l’équipement et les connaissances du personnel dans la prévention de la transmission mère-enfant (PTME) dans les services de soins de santé en zones rurales récemment couvertes par le programme national de PTME au Cameroun. Méthodes: Dans huit districts, l’inventaire des stocks d’antiviraux et des kits de test VIH a été effectué sur place, en utilisant un formulaire standardisé. Les connaissances sur le VIH et la PTME ont étéévaluées avec un questionnaire à choix multiple basé sur des cas cliniques typiques de PTME. Le personnel a pris part ensuite à une formation de deux jours sur le VIH/SIDA et les directives sur la PTME au Cameroun. Immédiatement après la formation et sept mois après, la rétention des connaissances a été testée avec les mêmes questions mais dans un ordre et une présentation différents. Résultats: 62 cliniques périphériques dirigées par des infirmières et 8 hôpitaux de district ont étéévalués. Alors que tous les hôpitaux de district possédaient un équipement complet, seules 6 des cliniques périphériques (10%) étaient équipées à la fois de matériel de dépistage complet et l’ensemble des médicaments pour la PTME. 36 services périphériques (58%) possédaient l’équipement complet pour le dépistage du VIH et 8 (13%) possédaient un stock de tous les médicaments pour la PTME. Sur 137 infirmières, 102 (74%) ont participé aux tests sur les deux connaissances. Moins de 66% savaient que le diagnostic du VIH exigeait des résultats positifs dans deux différents types de tests rapides et seules 19% ont choisi la recommandation adéquate sur l’alimentation du nourrisson pour les mères séropositives. Les réponses correctes sur les régimes de médicaments dans les différents sites de PTME variaient de 25%à 56%. Tous les pourcentages de réponses correctes s’amélioraient significativement avec la formation (p <0,001) et la rétention des connaissances restait élevée sept mois après la formation (p <0,001). Conclusions: Les programmes PTME dans des cadres tels que le milieu rural au Cameroun devraient être adaptés aux besoins spécifiques des cliniques périphériques dirigées par des infirmières. La formation appropriée de courte durée peut améliorer considérablement la compétence des infirmières dans la PTME. D’autres éléments importants sont : le contrôle régulier et des mesures visant à garantir l’approvisionnement de l’équipement dans les zones rurales. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases
KW - ANTIVIRAL agents
KW - TROPICAL medicine
KW - MEDICAL care
KW - CAMEROON
KW - África
KW - Africa
KW - Afrique
KW - antenatal care
KW - Camerún
KW - Cameroon
KW - Cameroun
KW - Cuidados antenatales
KW - entrenamiento de enfermeras
KW - formation des infirmières
KW - human immunodeficiency virus
KW - nurse training
KW - prévention de la transmission mère-enfant
KW - Prevención de la transmisión vertical
KW - prevention of mother-to-child transmission
KW - soins prénataux
KW - VIH
N1 - Accession Number: 36518592; Labhardt, Niklaus Daniel 1; Email Address: niklaus.labhardt@gmail.com Manga, Engelbert 2 Ndam, Mama 2 Balo, Jean-Richard 2 Bischoff, Alexandre 3 Stoll, Beat 4; Affiliation: 1: Office of the Surgeon General Basel-Stadt, Basel-Stadt, Switzerland 2: Ministry of Public Health of Cameroon, Cameroon 3: University Hospitals of Geneva, Geneva, Switzerland 4: Faculty of Medicine, University of Geneva, Geneva, Switzerland; Source Info: Mar2009, Vol. 14 Issue 3, p288; Subject Term: COMMUNICABLE diseases; Subject Term: ANTIVIRAL agents; Subject Term: TROPICAL medicine; Subject Term: MEDICAL care; Subject Term: CAMEROON; Author-Supplied Keyword: África; Author-Supplied Keyword: Africa; Author-Supplied Keyword: Afrique; Author-Supplied Keyword: antenatal care; Author-Supplied Keyword: Camerún; Author-Supplied Keyword: Cameroon; Author-Supplied Keyword: Cameroun; Author-Supplied Keyword: Cuidados antenatales; Author-Supplied Keyword: entrenamiento de enfermeras; Author-Supplied Keyword: formation des infirmières; Author-Supplied Keyword: human immunodeficiency virus; Author-Supplied Keyword: nurse training; Author-Supplied Keyword: prévention de la transmission mère-enfant; Author-Supplied Keyword: Prevención de la transmisión vertical; Author-Supplied Keyword: prevention of mother-to-child transmission; Author-Supplied Keyword: soins prénataux; Author-Supplied Keyword: VIH; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1365-3156.2009.02221.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36518592&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Le Nouën, Cyril
AU - Munir, Shirin
AU - Losq, Stéphanie
AU - Winter, Christine C.
AU - McCarty, Thomas
AU - Stephany, David A.
AU - Holmes, Kevin L.
AU - Bukreyev, Alexander
AU - Rabin, Ronald L.
AU - Collins, Peter L.
AU - Buchholz, Ursula J.
T1 - Infection and maturation of monocyte-derived human dendritic cells by human respiratory syncytial virus, human metapneumovirus, and human parainfluenza virus type 3
JO - Virology
JF - Virology
Y1 - 2009/03//
VL - 385
IS - 1
M3 - Article
SP - 169
EP - 182
SN - 00426822
AB - Abstract: Human respiratory syncytial virus (HRSV), human metapneumovirus (HMPV), and human parainfluenza virus type 3 (HPIV3) are common, important respiratory pathogens, but HRSV has a substantially greater impact with regard to acute disease, long-term effects on airway function, and frequency of re-infection. It has been reported to strongly interfere with the functioning of dendritic cells (DC). We compared HRSV to HMPV and HPIV3 with regard to their effects on human monocyte-derived immature DC (IDC). Side-by-side analysis distinguished between common effects versus those specific to individual viruses. The use of GFP-expressing viruses yielded clear identification of robustly infected cells and provided the means to distinguish between direct effects of robust viral gene expression versus bystander effects. All three viruses infected inefficiently based on GFP expression, with considerable donor-to donor-variability. The GFP-negative cells exhibited low, abortive levels of viral RNA synthesis. The three viruses induced low-to-moderate levels of DC maturation and cytokine/chemokine responses, increasing slightly in the order HRSV, HMPV, and HPIV3. Infection at the individual cell level was relatively benign, such that in general GFP-positive cells were neither more nor less able to mature compared to GFP-negative bystanders, and cells were responsive to a secondary treatment with lipopolysaccharide, indicating that the ability to mature was not impaired. However, there was a single exception, namely that HPIV3 down-regulated CD38 expression at the RNA level. Maturation by these viruses was anti-apoptotic. Inefficient infection of IDC and sub-optimal maturation might result in reduced immune responses, but these effects would be common to all three viruses rather than specific to HRSV. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORY syncytial virus
KW - PARAINFLUENZA viruses
KW - MONOCYTES
KW - DENDRITIC cells
KW - VIRAL genetics
KW - GENE expression
KW - IMMUNE response -- Regulation
KW - CYTOKINES
KW - Cytokine
KW - Maturation marker
KW - Metapneumovirus
KW - Monocyte derived dendritic cells
KW - Paramyxovirus
KW - Pneumovirus
N1 - Accession Number: 36607078; Le Nouën, Cyril 1 Munir, Shirin 1 Losq, Stéphanie 1 Winter, Christine C. 1 McCarty, Thomas 1 Stephany, David A. 2 Holmes, Kevin L. 2 Bukreyev, Alexander 1 Rabin, Ronald L. 3 Collins, Peter L. 1 Buchholz, Ursula J. 1; Email Address: ubuchholz@niaid.nih.gov; Affiliation: 1: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 2: Flow Cytometry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 3: Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Mar2009, Vol. 385 Issue 1, p169; Subject Term: RESPIRATORY syncytial virus; Subject Term: PARAINFLUENZA viruses; Subject Term: MONOCYTES; Subject Term: DENDRITIC cells; Subject Term: VIRAL genetics; Subject Term: GENE expression; Subject Term: IMMUNE response -- Regulation; Subject Term: CYTOKINES; Author-Supplied Keyword: Cytokine; Author-Supplied Keyword: Maturation marker; Author-Supplied Keyword: Metapneumovirus; Author-Supplied Keyword: Monocyte derived dendritic cells; Author-Supplied Keyword: Paramyxovirus; Author-Supplied Keyword: Pneumovirus; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.virol.2008.11.043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36607078&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jones, Ellen L.
AU - Gaither, Marlene
AU - Kramer, Adam
AU - Gerba, Charles P.
T1 - An Analysis of Water Quality in the Colorado River, 2003-04; An Investigation Into Recurring Outbreaks of Norovirus Among Rafters.
JO - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
JF - Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.)
Y1 - 2009///Spring2009
VL - 20
IS - 1
M3 - Article
SP - 6
EP - 13
PB - Allen Press Publishing Services Inc.
SN - 10806032
AB - Background.--Every year over 22 000 people raft the Colorado River through the Grand Canyon in Arizona. Since 1994, over 400 rafters in 6 separate outbreaks have become ill with norovirus while rafting this stretch of the river. Objectives.--To assess potential causes of these outbreaks, Colorado River water, water from nearby wastewater treatment plants, and a drinking water source were sampled and tested for norovirus and other water quality indicators. Methods.--Colorado River water was collected and sampled during the 2004 rafting season. Water from wastewater treatment plants near the Lee's Ferry launch site and drinking water from the Lee's Ferry launch site were also examined during the 2003 and 2004 rafting seasons. Stool samples from ill rafters and composite stool samples from onboard toilet-cans were tested for the presence of norovirus during the 2003 and 2004 outbreaks. Parameters examined included the following: norovirus by reverse transcriptase--polymerase chain reaction, coliforms, Escherichia coli, temperature, turbidity, and pH. Results.--No norovirus was detected in the Colorado River during the 2004 field sampling. Norovirus was detected in the Glen Canyon Dam Wastewater Treatment Plant on one occasion in 2004. Drinking water from the Lee's Ferry launch site was negative for norovirus in 2003, and Colorado River water from the Lee's Ferry launch site was negative for norovirus in 2004. In 2003, 3 of 10 stool samples from ill rafters or onboard toilet-cans were positive for norovirus. Neither of 2 stool samples collected in 2004 was positive for norovirus. Conclusions.--Colorado River water tested during nonoutbreak periods was negative for norovirus, indicating that there is not an ongoing high level of norovirus contamination in the river. No source or sources of contamination could be identified from the testing. Potential sources of norovirus outbreaks among rafters include drinking contaminated river water, consuming contaminated foodstuff, rafter importation of the virus and subsequent person-to-person spread, and contaminated fomites, campsites, or equipment. It is likely outbreaks are the result of more than one source of norovirus, and the exact source remains unknown for several outbreaks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Wilderness & Environmental Medicine (Allen Press Publishing Services Inc.) is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pandemics
KW - Sewage disposal plants
KW - Drinking water
KW - Water quality
KW - Noroviruses
KW - Rafting (Sports)
KW - Colorado River
KW - norovirus
KW - outbreak
KW - recreational water
KW - river rafters
N1 - Accession Number: 36877430; Jones, Ellen L. 1; Email Address: ellenjones@gmail.com; Gaither, Marlene 2; Kramer, Adam 3; Gerba, Charles P. 1; Affiliations: 1: Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, AZ; 2: Coconino County Health Department, Environmental Health Division, Flagstaff, AZ; 3: Public Health Service/National Park Service, Intermountain Region, Flagstaff, AZ; Issue Info: Spring2009, Vol. 20 Issue 1, p6; Thesaurus Term: Pandemics; Thesaurus Term: Sewage disposal plants; Thesaurus Term: Drinking water; Thesaurus Term: Water quality; Subject Term: Noroviruses; Subject Term: Rafting (Sports); Author-Supplied Keyword: Colorado River; Author-Supplied Keyword: norovirus; Author-Supplied Keyword: outbreak; Author-Supplied Keyword: recreational water; Author-Supplied Keyword: river rafters; NAICS/Industry Codes: 713990 All Other Amusement and Recreation Industries; NAICS/Industry Codes: 237110 Water and Sewer Line and Related Structures Construction; NAICS/Industry Codes: 562210 Waste treatment and disposal; NAICS/Industry Codes: 562212 Solid Waste Landfill; NAICS/Industry Codes: 221320 Sewage Treatment Facilities; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105482892
T1 - Increasing participation of women in early phase clinical trials approved by the FDA.
AU - Pinnow E
AU - Sharma P
AU - Parekh A
AU - Gevorkian N
AU - Uhl K
Y1 - 2009/03//
N1 - Accession Number: 105482892. Language: English. Entry Date: 20090626. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Women's Health. NLM UID: 9101000.
KW - Clinical Trials
KW - Consumer Participation
KW - Research Subjects
KW - Women
KW - Chi Square Test
KW - Descriptive Statistics
KW - Evaluation Research
KW - Female
KW - Male
KW - P-Value
KW - Sex Factors
KW - United States Food and Drug Administration
KW - Human
SP - 89
EP - 93
JO - Women's Health Issues
JF - Women's Health Issues
JA - WOMENS HEALTH ISSUES
VL - 19
IS - 2
CY - New York, New York
PB - Elsevier Science
SN - 1049-3867
AD - US Food and Drug Administration, Rockville, Maryland.
U2 - PMID: 19272558.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105482892&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-03751-006
AN - 2009-03751-006
AU - Voeten, Helene A. C. M
AU - de Zwart, Onno
AU - Veldhuijzen, Irene K.
AU - Yuen, Cicely
AU - Jiang, Xinyi
AU - Elam, Gillian
AU - Abraham, Thomas
AU - Brug, Johannes
T1 - Sources of information and health beliefs related to SARS and avian influenza among Chinese communities in the United Kingdom and the Netherlands, compared to the general population in these countries.
JF - International Journal of Behavioral Medicine
JO - International Journal of Behavioral Medicine
JA - Int J Behav Med
Y1 - 2009/03//
VL - 16
IS - 1
SP - 49
EP - 57
CY - Germany
PB - Springer
SN - 1070-5503
SN - 1532-7558
AD - Voeten, Helene A. C. M, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, Netherlands
N1 - Accession Number: 2009-03751-006. PMID: 19184453 Partial author list: First Author & Affiliation: Voeten, Helene A. C. M; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands. Other Publishers: Lawrence Erlbaum; Taylor & Francis. Release Date: 20090824. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Chinese Cultural Groups; Health Attitudes; Influenza; Information; Respiratory Tract Disorders. Minor Descriptor: Population; Risk Perception. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: United Kingdom; Netherlands. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Mar, 2009.
AB - Background: Ethnic minorities in Europe such as the Chinese may need a special strategy with regard to risk communication about emerging infectious diseases. To engage them in precautionary actions, it is important to know their information sources, knowledge, and health beliefs. Purpose: This study’s purpose is to study the use of information sources, knowledge, and health beliefs related to SARS and avian flu of Chinese people in the UK and The Netherlands, and to make comparisons with the general population in these countries. Method: Results of a self-administered questionnaire among 300 British/Dutch Chinese were compared to data obtained from a computer-assisted phone survey among the general population (n = 800). Results: British/Dutch Chinese got most information about emerging diseases from family and friends, followed by Chinese media and British/Dutch TV. They had less confidence than general groups in their doctor, government agencies, and consumer/patient interest groups. Their knowledge of SARS was high. They had a lower perceived threat than general populations with regard to SARS and avian flu due to a lower perceived severity. They had higher self-efficacy beliefs regarding SARS and avian flu. Conclusion: In case of new outbreaks of SARS/avian flu in China, local authorities in the UK and The Netherlands can best reach Chinese people through informal networks and British/Dutch TV, while trying to improve confidence in information from the government. In communications, the severity of the disease rather than the susceptibility appears to need most attention. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health beliefs
KW - avian influenza
KW - general population
KW - severe acute respiratory syndrome
KW - information sources
KW - United Kingdom
KW - Netherlands
KW - Chinese communities
KW - 2009
KW - Chinese Cultural Groups
KW - Health Attitudes
KW - Influenza
KW - Information
KW - Respiratory Tract Disorders
KW - Population
KW - Risk Perception
KW - 2009
U1 - Sponsor: European Commission, Sixth Framework Programme. Grant: SP22-CT-2004-003824. Other Details: Thematic Priority Scientific Support to Policies. Recipients: No recipient indicated
DO - 10.1007/s12529-008-9006-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03751-006&site=ehost-live&scope=site
UR - h.voeten@erasmusmc.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03751-007
AN - 2009-03751-007
AU - Jiang, Xinyi
AU - Elam, Gillian
AU - Yuen, Cicely
AU - Voeten, Helene
AU - de Zwart, Onno
AU - Veldhuijzen, Irene
AU - Brug, Johannes
T1 - The perceived threat of SARS and its impact on precautionary actions and adverse consequences: A qualitative study among Chinese communities in the United Kingdom and the Netherlands.
JF - International Journal of Behavioral Medicine
JO - International Journal of Behavioral Medicine
JA - Int J Behav Med
Y1 - 2009/03//
VL - 16
IS - 1
SP - 58
EP - 67
CY - Germany
PB - Springer
SN - 1070-5503
SN - 1532-7558
AD - Jiang, Xinyi, University of Dundee, Queen Mother Building, Dundee, United Kingdom, DD1 4HN
N1 - Accession Number: 2009-03751-007. PMID: 19277874 Partial author list: First Author & Affiliation: Jiang, Xinyi; Health Protection Agency, Centre for Infections, London, United Kingdom. Other Publishers: Lawrence Erlbaum; Taylor & Francis. Release Date: 20090824. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Chinese Cultural Groups; Health Behavior; Respiratory Tract Disorders; Risk Perception. Minor Descriptor: Syndromes; Threat; Consequence. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: United Kingdom; Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Mar, 2009.
AB - Background: Although the SARS outbreak involved few probable cases of infection in Europe, swift international spread of infections raised the possibility of outbreaks. In particular, SARS presented a sociopsychological and economic threat to European Chinese communities because of their close links with the outbreak’s origins. Methods: A qualitative study was conducted among Chinese residents in the United Kingdom and the Netherlands to identify the origins of SARS risk perceptions and their impact on precautionary actions and adverse consequences from the perspective of vulnerable communities living in unaffected regions. Analysis was informed by protection motivation theory. Results: Results revealed that information from affected Asia influenced risk perceptions and protective behavior among the Chinese in Europe when more relevant local information was absent. When high risk perceptions were combined with low efficacy regarding precautionary measures, avoidance-based precautionary action appeared to dominate responses to SARS. These actions may have contributed to the adverse impacts of SARS on the communities. Conclusions: Experiences of European Chinese communities suggest that practical and timely information, and consistent implementation of protective measures from central governments are essential to protect vulnerable populations in unaffected regions from unnecessary alarm and harm during outbreaks of emerging infections. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - perceived threat
KW - precautionary actions
KW - severe acute respiratory syndrome
KW - adverse consequences
KW - Chinese communities
KW - United Kingdom
KW - Netherlands
KW - risk perceptions
KW - 2009
KW - Chinese Cultural Groups
KW - Health Behavior
KW - Respiratory Tract Disorders
KW - Risk Perception
KW - Syndromes
KW - Threat
KW - Consequence
KW - 2009
DO - 10.1007/s12529-008-9005-5
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03751-007&site=ehost-live&scope=site
UR - x.y.jiang@dundee.ac.uk
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03819-008
AN - 2009-03819-008
AU - Salerno, Amy
AU - Carroll, Christopher
AU - Cruz, Marcelo
AU - Jue, Ken
AU - Silvestri, Fran
AU - Culebras, Manuela
T1 - Developing comprehensive community mental health services in developing countries: A practical application in Quito, Ecuador.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2009///Spr 2009
VL - 38
IS - 1
SP - 87
EP - 99
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2009-03819-008. Partial author list: First Author & Affiliation: Salerno, Amy; University of Pittsburgh School of Medicine, Pittsburgh, PA, US. Other Publishers: Taylor & Francis. Release Date: 20090824. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Developing Countries. Classification: Community & Social Services (3373). Population: Human (10). Location: Ecuador. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Spr 2009.
AB - Mental health services in resource-poor communities and countries presents a challenge. In one area of Quito, Ecuador, a community based system is being developed. Area 14, which has a population of about 120,000—52 percent of which live below the poverty line—is a suburb of Quito. Through interviews and focal groups, community members themselves have identified the most pressing issues of mental health: domestic violence, alcohol and drug use, adolescent pregnancy, and emigration. With this information, 8 pilot programs have been proposed and will be implemented over a 5-year plan. Existing community resources and organizations have been identified and a mental health network has been formed with these organizations. The knowledge that is generated in the successes and difficulties with this project will be useful in helping to develop similar projects elsewhere in Ecuador and in other developing countries. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - community mental health services
KW - developing countries
KW - 2009
KW - Community Mental Health Services
KW - Developing Countries
KW - 2009
DO - 10.2753/IMH0020-7411380108
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03819-008&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18291-002
AN - 2009-18291-002
AU - Pinnow, Ellen
AU - Sharma, Pellavi
AU - Parekh, Ameeta
AU - Gevorkian, Natalie
AU - Uhl, Kathleen
T1 - Increasing participation of women in early phase clinical trials approved by the FDA.
JF - Women's Health Issues
JO - Women's Health Issues
JA - Womens Health Issues
Y1 - 2009/03//Mar-Apr, 2009
VL - 19
IS - 2
SP - 89
EP - 93
CY - Netherlands
PB - Elsevier Science
SN - 1049-3867
AD - Pinnow, Ellen, US Food and Drug Administration, 1350 Piccard, Rockville, MD, US, 20850
N1 - Accession Number: 2009-18291-002. PMID: 19272558 Partial author list: First Author & Affiliation: Pinnow, Ellen; US Food and Drug Administration, Rockville, MD, US. Release Date: 20101129. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Experimental Subjects; Government Agencies. Minor Descriptor: Human Females. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Mar-Apr, 2009. Publication History: Accepted Date: Sep 28, 2008; Revised Date: Sep 27, 2008; First Submitted Date: May 13, 2008. Copyright Statement: Jacobs Institute of Women’s Health. Published by Elsevier Inc. 2009.
AB - Background: Historically women were excluded from participation in phase 1 clinical trials. The goal of this study was to determine the participation of women and evaluate if participation has increased over time. Methods: Clinical trial data submitted to the FDA for New Molecular Entities (NMEs) for adult, non-sex specific indications between January 2006 and December 2007 were reviewed. Electronic data available on phase 1 trial were evaluated for proposed indications, sex of participants, and doses tested. Therapeutic doses were obtained from the approved labeling. Results: FDA approved 34 NMEs in 2006–2007. Data for 352 phase 1 trial of 30 NMEs were obtained. Data for 1 NME was not available electronically, 2 did not include new phase 1 data, and 1 provided only summary demographic data. All NMEs reviewed were for drugs used to treat conditions occurring in both men and women. Overall 120 (34.1%) trials had only male participants while 232 (65.9%) trials also enrolled female participants. 30.6% (3106/10,134) of participants were women. 149/352 (42.3%) of trials included safety and tolerability testing above the highest approved dose. In those trials, 32.5% (1628/5011) of the participants were women. An evaluation of trial start date illustrated the number of trials that enrolled women (p = 0.01) and the number of female participants (p < 0.001) has increased over time. Conclusion: Females subjects have traditionally been underrepresented in phase 1 trials. The number trials enrolling women and the number of women participating in phase 1 trials has increased since 2001, however, women are still underrepresented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women participation
KW - Food & Drug Administration
KW - drug treatment
KW - 2009
KW - Clinical Trials
KW - Experimental Subjects
KW - Government Agencies
KW - Human Females
KW - 2009
DO - 10.1016/j.whi.2008.09.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18291-002&site=ehost-live&scope=site
UR - ellen.pinnow@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03819-009
AN - 2009-03819-009
AU - Daniels, Allen S.
AU - Adams, Neal
AU - Carroll, Christopher
AU - Beinecke, Richard H.
T1 - A conceptual model for behavioral health and primary care integration.
JF - International Journal of Mental Health
JO - International Journal of Mental Health
JA - Int J Ment Health
Y1 - 2009///Spr 2009
VL - 38
IS - 1
SP - 100
EP - 112
CY - US
PB - ME Sharpe
SN - 0020-7411
N1 - Accession Number: 2009-03819-009. Partial author list: First Author & Affiliation: Daniels, Allen S.; Clinical Psychiatry and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, US. Other Publishers: Taylor & Francis. Release Date: 20090824. Correction Date: 20160114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Drug Rehabilitation; Integrated Services; Mental Health Services; Primary Health Care. Minor Descriptor: Health Care Psychology; Quality of Care. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 13. Issue Publication Date: Spr 2009.
AB - In many countries, there is a growing concern about the lack of coordination and integration of primary care with services for mental and substance-use conditions: Care is all too often fragmented across the spectrum of general medical and specialty behavioral health systems. This fragmentation tends to perpetuate systems of care that are not sensitive to the needs of individuals, provide poor quality of care, and produce inconsistent health outcomes. General health care functions across a continuum of care that includes prevention, primary care, and chronic care management. The articulation of the common elements in general and behavioral health care along that continuum has the potential to foster a framework for enhanced coordination of care for individuals in the context of improved systems of care that better supports recovery and favorable health outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - behavioral health
KW - primary care
KW - mental health services
KW - substance abuse
KW - quality of care
KW - 2009
KW - Drug Rehabilitation
KW - Integrated Services
KW - Mental Health Services
KW - Primary Health Care
KW - Health Care Psychology
KW - Quality of Care
KW - 2009
DO - 10.2753/IMH0020-7411380109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03819-009&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05219-012
AN - 2009-05219-012
AU - McAuley, William J.
AU - Spector, William
AU - Van Nostrand, Joan
T1 - Formal home care utilization patterns by rural-urban community residence.
JF - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JO - The Journals of Gerontology: Series B: Psychological Sciences and Social Sciences
JA - J Gerontol B Psychol Sci Soc Sci
Y1 - 2009/03//
VL - 64
IS - 2
SP - 258
EP - 268
CY - United Kingdom
PB - Oxford University Press
SN - 1079-5014
SN - 1758-5368
AD - McAuley, William J., Department of Communication, George Mason University, 4400 University Drive, Research 1 Building, Room 253, MSN 6A9, Fairfax, VA, US, 22030
N1 - Accession Number: 2009-05219-012. PMID: 19196690 Partial author list: First Author & Affiliation: McAuley, William J.; Department of Communication, George Mason University, Fairfax, VA, US. Other Publishers: Gerontological Society of America. Release Date: 20090706. Correction Date: 20160912. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: McAuley, William J. Major Descriptor: Health Care Utilization; Home Care; Rural Environments; Urban Environments. Minor Descriptor: Needs. Classification: Home Care & Hospice (3375). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Mar, 2009. Publication History: Accepted Date: Sep 17, 2008; First Submitted Date: Jan 16, 2007. Copyright Statement: The Authors. 2009.
AB - Background: We examined formal home care utilization among civilian adults across metro and nonmetro residential categories before and after adjustment for predisposing, enabling, and need variables. Methods: Two years of the Medical Expenditure Panel Survey (MEPS) were combined to produce a nationally representative sample of adults who resided in the community for a calendar year. We established 6 rural-urban categories based upon Urban Influence Codes and examined 2 dependent variables: (a) likelihood of using any formal home care and (b) number of provider days received by users. The Area Resource File provided county-level information. Logistic and negative binomial regression analyses were employed, with adjustments for the MEPS complex sampling design and the combined years. Results: Under controls for predisposing, enabling, and need variables, differences in likelihood of any formal home care use disappear, but differences in number of provider days received by users emerged, with fewer provider days in remote areas than in metro and several other nonmetro types. Conclusions: It is important to fully account for predisposing, enabling, and need factors when assessing rural and urban home care utilization patterns. The limited provider days in remote counties under controls suggest a possible access problem for adults in these areas. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - formal home care utilization
KW - rural-urban community residence
KW - needs
KW - civilians
KW - 2009
KW - Health Care Utilization
KW - Home Care
KW - Rural Environments
KW - Urban Environments
KW - Needs
KW - 2009
U1 - Sponsor: Health Resources and Services Administration. Recipients: No recipient indicated
U1 - Sponsor: Agency for Healthcare Research and Quality. Other Details: Long-Term Care Scholar in Residence. Recipients: McAuley, William J.
DO - 10.1093/geronb/gbn003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05219-012&site=ehost-live&scope=site
UR - wmcauley@gmu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03492-006
AN - 2009-03492-006
AU - Willour, V. L.
AU - Chen, H.
AU - Toolan, J.
AU - Belmonte, P.
AU - Cutler, D. J.
AU - Goes, F. S.
AU - Zandi, P. P.
AU - Lee, R. S.
AU - MacKinnon, D. F.
AU - Mondimore, F. M.
AU - Schweizer, B.
AU - DePaulo, J. R. Jr.
AU - Gershon, E. S.
AU - McMahon, F. J.
AU - Potash, J. B.
T1 - Family-based association of FKBP5 in bipolar disorder.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2009/03//
VL - 14
IS - 3
SP - 261
EP - 268
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Willour, V. L., Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 4-143, 600 N Wolfe Street, Baltimore, MD, US, 21287
N1 - Accession Number: 2009-03492-006. PMID: 18180755 Partial author list: First Author & Affiliation: Willour, V. L.; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, US. Institutional Authors: Bipolar Disorder Phenome Group, NIMH Genetics Initiative Bipolar Disorder Consortium. Release Date: 20090706. Correction Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Willour, V. L. Major Descriptor: Bipolar Disorder; Genes; Nucleotides; Polymorphism; Risk Factors. Minor Descriptor: Family. Classification: Affective Disorders (3211). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Tests & Measures: Schedule for Affective Disorders and Schizophrenia-Lifetime Version; Diagnostic Interview for Genetic Studies. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2009. Publication History: First Posted Date: Jan 8, 2008; Accepted Date: Sep 18, 2007; Revised Date: Aug 29, 2007; First Submitted Date: Jun 25, 2007. Copyright Statement: All rights reserved. Nature Publishing Group. 2009.
AB - The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and with rapid response to antidepressant treatment. We sought to determine whether common FKBP5 variants confer risk for bipolar disorder. We genotyped seven tag single-nucleotide polymorphisms (SNPs) in FKBP5, plus two SNPs previously associated with illness, in 317 families with 554 bipolar offspring, derived primarily from two studies. Single marker and haplotypic analyses were carried out with FBAT and EATDT employing the standard bipolar phenotype. Association analyses were also conducted using 11 disease-related variables as covariates. Under an additive genetic model, rs4713902 showed significant overtransmission of the major allele (P = 0.0001), which was consistent across the two sample sets (P = 0.004 and 0.006). rs7757037 showed evidence of association that was strongest under the dominant model (P = 0.001). This result was consistent across the two datasets (P = 0.017 and 0.019). The dominant model yielded modest evidence for association (P < 0.05) for three additional markers. Covariate-based analyses suggested that genetic variation within FKBP5 may influence attempted suicide and number of depressive episodes in bipolar subjects. Our results are consistent with the well-established relationship between the hypothalamic-pituitary-adrenal (HPA) axis, which mediates the stress response through regulation of Cortisol, and mood disorders. Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - family-based association
KW - FKBP5 gene
KW - bipolar disorder
KW - risk factors
KW - single-nucleotide polymorphisms
KW - 2009
KW - Bipolar Disorder
KW - Genes
KW - Nucleotides
KW - Polymorphism
KW - Risk Factors
KW - Family
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH-042243; R01 MH-061613. Recipients: No recipient indicated
U1 - Sponsor: Charles A Dana Foundation. Other Details: Consortium on the Genetic Basis of Manic Depressive Illness. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Alex Brown Foundation. Recipients: No recipient indicated
U1 - Sponsor: Stanley Medical Research Institute. Recipients: No recipient indicated
U1 - Sponsor: Margaret Ann Price. Other Details: Investigatorships. Recipients: Willour, V. L.; Potash, J. B.
DO - 10.1038/sj.mp.4002141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03492-006&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - willour@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03824-001
AN - 2009-03824-001
AU - Yang, Yongsheng
AU - Carlin, Alan S.
AU - Faustino, Patrick J.
AU - Motta, Mónica I. Pagán
AU - Hamad, Mazen L.
AU - He, Ruyi
AU - Watanuki, Y.
AU - Pinnow, E. E.
AU - Khan, Mansoor A.
T1 - Participation of women in clinical trials for new drugs approved by the Food and Drug Administration in 2000-2002.
JF - Journal of Women's Health
JO - Journal of Women's Health
JA - J Womens Health (Larchmt)
Y1 - 2009/03//
VL - 18
IS - 3
SP - 303
EP - 310
CY - US
PB - Mary Ann Liebert, Inc.
SN - 1540-9996
SN - 1931-843X
AD - Yang, Yongsheng, FDA/Center for Drug Evaluation and Research, White Oak Life Sciences Building 64, Room 1024, 10903 New Hampshire Avenue, Silver Spring, MD, US, 20993
N1 - Accession Number: 2009-03824-001. PMID: 19243271 Other Journal Title: Journal of Women's Health & Gender-Based Medicine. Partial author list: First Author & Affiliation: Yang, Yongsheng; Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, US. Release Date: 20090518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Databases; Drug Legalization; Drugs; Pharmacokinetics. Minor Descriptor: Human Sex Differences; Labeling; Safety. Classification: Drug & Alcohol Usage (Legal) (2990). Population: Human (10); Female (40). Methodology: Literature Review. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2009.
AB - Objective: This study aimed to track the inclusion of women in clinical trials for new drugs approved by the Food and Drug Administration (FDA) between 2000 and 2002 and to evaluate the extent of analyses by sex. Methods: Data were extracted from FDA reviewers’ reports, summaries of clinical trials in New Drug Applications (NDAs), and product labeling and organized into a Microsoft Access database. The information collected includes subject enrollment by sex per clinical phase and sex differences in pharmacokinetics, safety, and efficacy as determined by either sponsors or reviewers. Results: There were 67 New Molecular Entities (NMEs) approved by the FDA between 2000 and 2002. A total of 397,825 subjects were enrolled in 2,323 clinical trials. If 9 sex-specific NMEs are excluded, 297,697 subjects were enrolled in 1,974 clinical trials. Forty-seven percent of participants were male, 49% were female, and 4% of subjects were not specified. Of the 58 sex-nonspecific products in the study, 71% (41 of 58) of sex analyses were performed either by the sponsor or FDA reviewers. Twenty-five NMEs were found to have sex differences in pharmacokinetics, efficacy or adverse events. However, no recommendation was made to adjust dosage based on sex differences. Conclusions: The percentages of women and men participating in clinical trials varied by year, phase, and product type. However, the overall participation by women and men was comparable, suggesting an improvement in including more women in clinical trials when compared with the previous FDA study evaluating women’s participation from 1995 through 1999. As with the previous study, however, a significant under representation of women in early phase trials and in certain areas, such as cardiovascular products, was observed and continues to be an issue of concern. Lack of appropriate analyses by sex should also be noted as an issue of concern. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women participation
KW - clinical trials
KW - new drugs
KW - Food and Drug Administration
KW - sex differences
KW - pharmacokinetics
KW - 2009
KW - Clinical Trials
KW - Databases
KW - Drug Legalization
KW - Drugs
KW - Pharmacokinetics
KW - Human Sex Differences
KW - Labeling
KW - Safety
KW - 2009
U1 - Sponsor: Food and Drug Administration, Office of Women’s Health. Recipients: No recipient indicated
DO - 10.1089/jwh.2008.0971
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03824-001&site=ehost-live&scope=site
UR - yongsheng.yang@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02665-007
AN - 2009-02665-007
AU - Fujishiro, Kaori
T1 - Is perceived racial privilege associated with health? Findings from the Behavioral Risk Factor Surveillance System.
JF - Social Science & Medicine
JO - Social Science & Medicine
JA - Soc Sci Med
Y1 - 2009/03//
VL - 68
IS - 5
SP - 840
EP - 844
CY - Netherlands
PB - Elsevier Science
SN - 0277-9536
SN - 1873-5347
AD - Fujishiro, Kaori, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation, and Field Studies, 4676 Columbia Parkway (R-17), Cincinnati, OH, US, 45226
N1 - Accession Number: 2009-02665-007. PMID: 19136189 Partial author list: First Author & Affiliation: Fujishiro, Kaori; National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation, and Field Studies, Cincinnati, OH, US. Release Date: 20090601. Correction Date: 20110905. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Race and Ethnic Discrimination; Racial and Ethnic Differences; Well Being. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Behavioral Risk Factor Surveillance System. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Mar, 2009.
AB - While racial discrimination has gained increasing attention in public health research, little is known about perceived racial privilege and health. Using the Behavioral Risk Factor Surveillance System (BRFSS) data, this study explored the relationship of both perceived racial discrimination and privilege with wellbeing in the USA. Data were extracted from the BRFSS 2004 data set, in which 22,412 respondents in seven states and one major city provided data on perceived racial discrimination and privilege at work. Logistic regression analysis was conducted to examine the relationships of differential racial treatment to self-rated general health status and the number of physically and mentally unhealthy days. Racially stratified analyses found that perceived racial privilege was significantly associated with more days of poor physical and mental health. This relationship was consistent for Whites, but for racial minorities it appeared on only some outcome measures. Reports of being treated worse than other races in the workplace were associated with poor health for all racial groups, as had been reported in previous studies on racial discrimination. Because racial discrimination and racial privilege are both products of racism, this study’s findings suggest that racism may harm all involved. Impacts of perceived racial privilege deserve more attention in the literature on racism and health. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - racial discrimination
KW - effects on well-being & health
KW - privilege at work
KW - racial privilege
KW - racial differences
KW - racism
KW - 2009
KW - Health
KW - Race and Ethnic Discrimination
KW - Racial and Ethnic Differences
KW - Well Being
KW - 2009
DO - 10.1016/j.socscimed.2008.12.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02665-007&site=ehost-live&scope=site
UR - kfujishiro@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-00905-025
AN - 2010-00905-025
AU - Kvigne, Valborg L.
AU - Leonardson, Gary R.
AU - Borzelleca, Joseph
AU - Neff-Smith, Martha
AU - Welty, Thomas K.
T1 - Characteristics of children whose siblings have fetal alcohol syndrome or incomplete fetal alcohol syndrome.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/03//
VL - 123
IS - 3
SP - e526
EP - e533
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Kvigne, Valborg L., 2013 W 15th St, #1, Sioux Falls, SD, US, 57104
N1 - Accession Number: 2010-00905-025. PMID: 19254987 Partial author list: First Author & Affiliation: Kvigne, Valborg L.; Aberdeen Area Indian Health Service, Aberdeen, SD, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Fetal Alcohol Syndrome; Siblings. Classification: Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100). Methodology: Clinical Case Study; Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Mar, 2009. Publication History: Accepted Date: Nov 25, 2008. Copyright Statement: American Academy of Pediatrics. 2009.
AB - Objective: To describe the clinical features of American Indian children born just before and just after a sibling with fetal alcohol syndrome or incomplete fetal alcohol syndrome. Methods: Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome or incomplete fetal alcohol syndrome identified from 1981 to 1993 by using International Classification of Diseases, Ninth Revision, Clinical Modification code 760.71. Results: Compared with the controls, the 39 siblings born just before children with fetal alcohol syndrome (study 1) and 30 siblings born just before children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (23.1% and 16.7%, respectively), growth delay (38.5% and 10.0%), and central nervous system impairment (48.7% and 33.3%). The 20 siblings born just after children with fetal alcohol syndrome (study 1) and 22 siblings born just after children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (20.0% and 9.1%, respectively), growth delay (45.0% and 22.7%), and central nervous system impairment (50.0% and 31.8%) than the control siblings. Conclusions: The 'before' siblings had characteristics of fetal alcohol syndrome that could have predicted that the next child was at risk for fetal alcohol syndrome. The 'after' siblings had better outcomes than the previous siblings with fetal alcohol syndrome, a finding that was associated with a decrease in maternal alcohol consumption during the after-sibling pregnancy. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - American Indian children
KW - clinical features
KW - siblings with fetal alcohol syndrome
KW - 2009
KW - American Indians
KW - Fetal Alcohol Syndrome
KW - Siblings
KW - 2009
U1 - Sponsor: IHS. Recipients: No recipient indicated
U1 - Sponsor: Centers for Disease Control and Prevention. Recipients: No recipient indicated
DO - 10.1542/peds.2008-2423
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-00905-025&site=ehost-live&scope=site
UR - kvig6@aol.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Baldwin, Julie A.
AU - Johnson, Jeannette L.
AU - Benally, Christine C.
T1 - Building Partnerships Between Indigenous Communities and Universities: Lessons Learned in HIV/AIDS and Substance Abuse Prevention Research.
JO - American Journal of Public Health
JF - American Journal of Public Health
Y1 - 2009/03/02/Mar2009 Supplement
VL - 99
M3 - Article
SP - S77
EP - S81
PB - American Public Health Association
SN - 00900036
AB - Many HIV/AIDS and substance abuse prevention studies in American Indian and Alaska Native communities have been directed by academic researchers with little community input. We examined the challenges in conducting HIV/ AIDS-related research in American Indian and Alaska Native communities and the benefits of changing the research paradigm to a community-based participatory model. The lessons we learned illustrate that the research process should be a cyclical one with continual involvement by community members. Steps in the process include (1) building and sustaining collaborative relationships, (2) planning the program together, (3) implementing and evaluating the program in culturally acceptable ways, and (4) disseminating research findings from a tribal perspective. These steps can enhance the long-term capacity of the community to conduct HIV/ AIDS and substance abuse prevention research. (Am J Public Health. 2009;99: S77-S82.) [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - AIDS (Disease) -- Research
KW - HIV infections
KW - RESEARCH
KW - SEXUALLY transmitted diseases -- Prevention
KW - INDIGENOUS peoples -- Education (Higher)
KW - PUBLIC health -- United States
KW - HIGHER education
KW - PLANNING
KW - UNITED States
N1 - Accession Number: 37000482; Baldwin, Julie A. 1; Email Address: jbaldwin@health.usf.edu Johnson, Jeannette L. 2 Benally, Christine C. 3; Affiliation: 1: Professor and Chair, Department of Community and Family Health, College of Public Health, University of South Florida, 13 201 Bruce B. Downs, Bird, MDC 56, Tampa, FL 33 612 2: Friends Research Institute, Baltimore, MD 3: Ft. Defiance Service Unit of the Indian Health Service, Fort Defiance, AZ; Source Info: Mar2009 Supplement, Vol. 99, pS77; Subject Term: PUBLIC health; Subject Term: AIDS (Disease) -- Research; Subject Term: HIV infections; Subject Term: RESEARCH; Subject Term: SEXUALLY transmitted diseases -- Prevention; Subject Term: INDIGENOUS peoples -- Education (Higher); Subject Term: PUBLIC health -- United States; Subject Term: HIGHER education; Subject Term: PLANNING; Subject Term: UNITED States; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 6p; Document Type: Article; Full Text Word Count: 5177
L3 - 10.2105/AJPH.2008.134585
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37000482&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dabelea, Dana
AU - DeGroat, Joquetta
AU - Sorrelman, Carmelita
AU - Glass, Martia
AU - Percy, Christopher A.
AU - Avery, Charlene
AU - Hu, Diana
AU - D'Agostino Jr., Ralph B.
AU - Beyer, Jennifer
AU - Imperatore, Giuseppina
AU - Testaverde, Lisa
AU - Klingensmith, Georgeanna
AU - Hamman, Richard F.
T1 - Diabetes in Navajo Youth.
JO - Diabetes Care
JF - Diabetes Care
Y1 - 2009/03/02/Mar2009 Supplement2
VL - 32
M3 - Article
SP - S141
EP - S147
SN - 01495992
AB - OBJECTIVE -- To estimate the prevalence and incidence of diabetes, clinical characteristics, and risk factors for chronic complications among Navajo youth, using data collected by the SEARCH for Diabetes in Youth Study (SEARCH study). RESEARCH DESIGN AND METHODS-- The SEARCH study identified all prevalent cases of diabetes in 2001 and all incident cases in 2002-2005 among Navajo youth. We estimated denominators with the user population for eligible health care facilities. Youth with diabetes also attended a research visit that included questionnaires, physical examination, blood and urine collection, and extended medical record abstraction. RESULTS-- Diabetes is infrequent among Navajo youth aged < 10 years. However, both prevalence and incidence of diabetes are high in older youth. Among adolescents aged 15-19 years, 1 in 359 Navajo youth had diabetes in 2001 and 1 in 2,542 developed diabetes annually. The vast majority of diabetes among Navajo youth with diabetes is type 2, although type t diabetes is also present, especially among younger children. Navajo youth with either diabetes type were likely to have poor glycemic control, high prevalence of unhealthy behaviors, and evidence of severely depressed mood. Youth with type 2 diabetes had more metabolic factors associated with obesity and insulin resistance (abdominal fat deposition, dyslipidemia, and higher albumin-to-creatinine ratio) than youth with type 1 diabetes. CONCLUSIONS -- Our data provide evidence that diabetes is an important health problem for Naviijo youth. Targeted efforts aimed at primary prevention of diabetes in Navajo youth and efforts to prevent or delay the development of chronic complications among those with diabetes are warranted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIABETES in youth
KW - NAVAJO (North American people)
KW - DISEASE prevalence
KW - DISEASES -- Risk factors
KW - DIABETES -- Complications
KW - UNITED States
N1 - Accession Number: 37262667; Dabelea, Dana 1; Email Address: dana.dabelea@ucdenver.edu DeGroat, Joquetta 2 Sorrelman, Carmelita 2 Glass, Martia 3 Percy, Christopher A. 2 Avery, Charlene 4 Hu, Diana 5 D'Agostino Jr., Ralph B. 6 Beyer, Jennifer 6 Imperatore, Giuseppina 7 Testaverde, Lisa 1 Klingensmith, Georgeanna 8 Hamman, Richard F. 1; Affiliation: 1: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado 2: Department of Health Promotion Disease Prevention, Northern Navajo Medical Center, Navajo Area Indian Health Service, Shiprock, New Mexico 3: Area Diabetes Program, Navajo Area Indian Health Service, Window Rock, Arizona 4: Diabetes Program, Gallup Indian Medical Center, Navajo Area Indian Health Service, Gallup, New Mexico 5: Pediatrics Department, Tuba City Regional Health Care Center, Tuba City, Arizona 6: Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Wake Forest, North Carolina 7: Centers for Disease Control and Prevention, Atlanta, Georgia 8: Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Colorado; Source Info: Mar2009 Supplement2, Vol. 32, pS141; Subject Term: DIABETES in youth; Subject Term: NAVAJO (North American people); Subject Term: DISEASE prevalence; Subject Term: DISEASES -- Risk factors; Subject Term: DIABETES -- Complications; Subject Term: UNITED States; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article; Full Text Word Count: 5011
L3 - 10.2337/dc09-S206
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37262667&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105505341
T1 - Recommended weight limits for lifting and holding limbs in the orthopaedic practice setting.
AU - Waters TR
AU - Sedlak CA
AU - Howe CM
AU - Gonzalez CM
AU - Doheny MO
AU - Patterson M
AU - Nelson A
Y1 - 2009/03/02/Mar/Apr2009 Safe Patient Handling
N1 - Accession Number: 105505341. Language: English. Entry Date: 20090529. Revision Date: 20150819. Publication Type: Journal Article; algorithm; CEU; exam questions; pictorial; tables/charts. Supplement Title: Mar/Apr2009 Safe Patient Handling. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 8409486.
KW - Cast Application
KW - Casts
KW - Lifting -- Standards
KW - Occupational-Related Injuries -- Prevention and Control
KW - Body Weights and Measures
KW - Education, Continuing (Credit)
KW - Extremities
KW - Nursing Assessment
KW - Orthopedic Nursing
KW - Transfer Techniques
KW - Weights and Measures
SP - S28
EP - 35
JO - Orthopaedic Nursing
JF - Orthopaedic Nursing
JA - ORTHOP NURS
VL - 28
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Vertical transfers of postoperative orthopaedic patients pose a high risk to healthcare workers for developing work-related musculoskeletal disorders. The task is considered high risk based on weight limits and awkward positioning. A task force including representatives from the National Association of Orthopaedic Nurses, the American Nurses Association, the National Institute for Occupational Safety and Health, the Patient Safety Center of Inquiry at the James A. Haley Veterans Administration Medical Center in Tampa, Diligent Services, and Guldmann, Inc., developed an ergonomic tool for determining best practices for safe vertical transfers. Current concepts of ergonomic safety, scientific evidence, and safe patient-handling equipment and devices were incorporated into this ergonomic tool.
SN - 0744-6020
AD - National Institute for Occupational Safety and Health, Cincinnati, OH
U2 - PMID: 19339856.
DO - 10.1097/NOR.0b013e3181997a7b
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105505341&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Akinbami, Lara J.
AU - Moorman, Jeanne E.
AU - Garbe, Paul L.
AU - Sondik, Edward J.
T1 - Status of Childhood Asthma in the United States, 1980-2007.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/03/02/Mar2009 Supplement 3
VL - 123
M3 - Article
SP - S131
EP - S145
SN - 00314005
AB - Centers for Disease Control and Prevention data were used to describe 1980-2007 trends among children 0 to 17 years of age and recent patterns according to gender, race, and age. Asthma period prevalence increased by 4.6% per year from 1980 to 1996. New measures introduced in 1997 show a plateau at historically high levels; 9.1 % of US children (6.7 million) currently had asthma in 2007. Ambulatory care visit rates fluctuated during the 1990s, whereas emergency department visits and hospitalization rates decreased slightly. Asthma-related death rates increased through the middle 1990s but decreased after 1999. Recent data showed higher prevalence among older children (11-17 years), but the highest rates of asthma- related health care use were among the youngest children (0-4 years). After controlling for racial differences in prevalence, disparities in adverse outcomes remained; among children with asthma, non-Hispanic black children had greater risks for emergency department visits and death, compared with non-Hispanic white children. For hospitalizations, for which Hispanic ethnicity data were not available, black children had greater risk than white children. However, nonemergency ambulatory care use was lower for non-Hispanic black children. Although the large increases in childhood asthma prevalence have abated, the burden remains large. Potentially avoidable adverse outcomes and racial disparities continue to present challenges. These findings suggest the need for sustained asthma prevention and control efforts for children. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - ASTHMA in children
KW - ASTHMATICS
KW - JUVENILE diseases
KW - EPIDEMIOLOGY
KW - DATA analysis
KW - DISEASE prevalence
KW - CHILD health services
KW - RACIAL differences
KW - asthma
KW - data analysis
KW - epidemiology
KW - trends
N1 - Accession Number: 36977631; Akinbami, Lara J. 1,2; Email Address: Iakinbami@cdc.gov Moorman, Jeanne E. 3 Garbe, Paul L. 3 Sondik, Edward J. 1; Affiliation: 1: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 2: US Public Health Service, Rockville, Maryland 3: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Mar2009 Supplement 3, Vol. 123, pS131; Subject Term: MEDICAL research; Subject Term: ASTHMA in children; Subject Term: ASTHMATICS; Subject Term: JUVENILE diseases; Subject Term: EPIDEMIOLOGY; Subject Term: DATA analysis; Subject Term: DISEASE prevalence; Subject Term: CHILD health services; Subject Term: RACIAL differences; Author-Supplied Keyword: asthma; Author-Supplied Keyword: data analysis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: trends; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 15p; Illustrations: 4 Charts, 9 Graphs; Document Type: Article
L3 - 10.1542/peds.2008-2233C
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36977631&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Klontz, Karl C.
AU - Abraham, Ann
AU - Plakas, Steven M.
AU - Dickey, Robert W.
T1 - Mussel-Associated Azaspiracid Intoxication in the United States.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/03/03/
VL - 150
IS - 5
M3 - Letter
SP - 361
EP - 361
SN - 00034819
AB - A letter to the editor is presented regarding mussel-associated azaspiracid intoxication in the U.S.
KW - LETTERS to the editor
KW - MUSSELS
N1 - Accession Number: 36812223; Klontz, Karl C. 1 Abraham, Ann 2 Plakas, Steven M. 2 Dickey, Robert W. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration College Park, MD 20740 2: Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration Dauphin Island, AL 36528; Source Info: 3/3/2009, Vol. 150 Issue 5, p361; Subject Term: LETTERS to the editor; Subject Term: MUSSELS; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 1/2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 105467403
T1 - This Wolfe isn't in sheep's clothing...Dr. Sidney Wolfe
AU - Cassels A
AU - Wolfe, Sidney
Y1 - 2009/03/03/
N1 - Accession Number: 105467403. Language: English. Entry Date: 20090417. Revision Date: 20161119. Publication Type: biography; biography; interview. Journal Subset: Biomedical; Canada; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed. NLM UID: 9711805.
KW - Consumer Advocacy -- History
KW - Drug and Narcotic Control -- History
KW - Drug Toxicity
KW - History
KW - Policy Making
KW - United States
KW - United States Food and Drug Administration
KW - Wolfe, Sidney
SP - 584
EP - 584
JO - CMAJ: Canadian Medical Association Journal
JF - CMAJ: Canadian Medical Association Journal
JA - CMAJ
VL - 180
IS - 5
CY - Ottowa, Ontario
PB - Joule Inc.
SN - 0820-3946
AD - Drug Safety and Risk Management Advisory ommittee, Food and Drug Administration, PHS/DHHS
U2 - PMID: 19255086.
DO - 10.1503/cmaj.090181
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105467403&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - De Jager, Lowri S.
AU - Perfetti, Gracia A.
AU - Diachenko, Gregory W.
T1 - Stir bar sorptive extraction–gas chromatography–mass spectrometry analysis of tetramethylene disulfotetramine in food: Method development and comparison to solid-phase microextraction
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2009/03/09/
VL - 635
IS - 2
M3 - Article
SP - 162
EP - 166
SN - 00032670
AB - Abstract: A stir bar sorptive extraction–gas chromatography–mass spectrometry (SBSE–GC–MS) method for the determination of tetramethylene disulfotetramine is presented. The limits of detection (LOD) of the optimized method was 0.2ngg−1 for extractions from water and 0.3–2.1ngg−1 for extractions from foods. Recovery was highly matrix dependent (36–130%) and quantification required standard addition calibrations. Standard addition calibration lines had high linearity (R 2 >0.97) and replicate extractions had good reproducibility (R.S.D.=4.4–9.8%). A comparison of the SBSE method and a previously developed headspace (HS)-solid-phase microextraction (SPME) method was performed. Generally, SBSE provided higher sensitivity with decreased analysis time. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOLID phase extraction
KW - FOOD -- Analysis
KW - GAS chromatography/Mass spectrometry (GC-MS)
KW - CYCLOBUTANE
KW - FOOD -- Toxicology
KW - Food analysis
KW - Food defense
KW - Solid-phase microextraction
KW - Stir bar sorptive extraction
KW - Tetramethylene disulfotetramine
KW - Tetramine
N1 - Accession Number: 36478581; De Jager, Lowri S.; Email Address: lowri.dejager@fda.hhs.gov Perfetti, Gracia A. 1 Diachenko, Gregory W. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Mar2009, Vol. 635 Issue 2, p162; Subject Term: SOLID phase extraction; Subject Term: FOOD -- Analysis; Subject Term: GAS chromatography/Mass spectrometry (GC-MS); Subject Term: CYCLOBUTANE; Subject Term: FOOD -- Toxicology; Author-Supplied Keyword: Food analysis; Author-Supplied Keyword: Food defense; Author-Supplied Keyword: Solid-phase microextraction; Author-Supplied Keyword: Stir bar sorptive extraction; Author-Supplied Keyword: Tetramethylene disulfotetramine; Author-Supplied Keyword: Tetramine; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.aca.2008.12.048
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36478581&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mazurek, J. M.
AU - Wood, J. M.
T1 - Asbestosis-Relatec Years of Potential Life Lost Before Age 65 Years-- United States, 1968-2005.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/03/11/
VL - 301
IS - 10
M3 - Article
SP - 1012
EP - 1014
SN - 00987484
AB - The article presents the results of an analysis by the U.S. Centers for Disease Control and Prevention of the underlying cause of death due to asbestosis. The goal was to characterize trends in premature mortality due to asbestosis in the U.S. Decedents with asbestosis listed as the underlying cause of death were identified from 1968-2005 mortality data. Asbestosis was found to the underlying cause of death for 9,024 decedents 25 to 34 years old. The number of years of potential life lost (YPLL) attrituted to asbestosis deaths increased 64%. According to industry and occupation information for the decedents, the greatest YPLL were in construction, ship and boat building, and military.
KW - ASBESTOSIS
KW - STATISTICS
KW - PUBLIC health
KW - INDUSTRIAL hygiene
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 36872497; Mazurek, J. M. 1 Wood, J. M. 1; Affiliation: 1: Div of Respiratory Disease Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 3/11/2009, Vol. 301 Issue 10, p1012; Subject Term: ASBESTOSIS; Subject Term: STATISTICS; Subject Term: PUBLIC health; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wollert, Thomas
AU - Wunder, Christian
AU - Lippincott-Schwartz, Jennifer
AU - Hurley, James H.
T1 - Membrane scission by the ESCRT-III complex.
JO - Nature
JF - Nature
Y1 - 2009/03/12/
VL - 458
IS - 7235
M3 - Article
SP - 172
EP - 177
PB - Nature Publishing Group
SN - 00280836
AB - The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis. In Saccharomyces cerevisiae, ESCRT-III consists of Vps20, Snf7, Vps24 and Vps2 (also known as Did4), which assemble in that order and require the ATPase Vps4 for their disassembly. In this study, the ESCRT-III-dependent budding and scission of intralumenal vesicles into giant unilamellar vesicles was reconstituted and visualized by fluorescence microscopy. Here we show that three subunits of ESCRT-III, Vps20, Snf7 and Vps24, are sufficient to detach intralumenal vesicles. Vps2, the ESCRT-III subunit responsible for recruiting Vps4, and the ATPase activity of Vps4 were required for ESCRT-III recycling and supported additional rounds of budding. The minimum set of ESCRT-III and Vps4 proteins capable of multiple cycles of vesicle detachment corresponds to the ancient set of ESCRT proteins conserved from archaea to animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SCISSION (Chemistry)
KW - CELL membranes -- Formation
KW - HIV (Viruses)
KW - FLUORESCENCE microscopy
KW - CYTOKINESIS
KW - RESEARCH
KW - SACCHAROMYCES cerevisiae
KW - PROTEINS -- Research
KW - GENETIC aspects
N1 - Accession Number: 36881026; Wollert, Thomas 1 Wunder, Christian 2 Lippincott-Schwartz, Jennifer 3 Hurley, James H. 4; Affiliation: 1: [1] Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, and, [2] These authors contributed equally to this work. 2: [1] Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA [2] These authors contributed equally to this work. 3: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA 4: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, and,; Source Info: 3/12/2009, Vol. 458 Issue 7235, p172; Subject Term: SCISSION (Chemistry); Subject Term: CELL membranes -- Formation; Subject Term: HIV (Viruses); Subject Term: FLUORESCENCE microscopy; Subject Term: CYTOKINESIS; Subject Term: RESEARCH; Subject Term: SACCHAROMYCES cerevisiae; Subject Term: PROTEINS -- Research; Subject Term: GENETIC aspects; Number of Pages: 6p; Illustrations: 6 Diagrams; Document Type: Article
L3 - 10.1038/nature07836
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36881026&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105487401
T1 - Screening for sickle cell disease in newborns.
AU - Lin KW
Y1 - 2009/03/15/
N1 - Accession Number: 105487401. Language: English. Entry Date: 20090508. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Anemia, Sickle Cell -- Diagnosis
KW - Neonatal Assessment
KW - Infant, Newborn
KW - Male
SP - 507
EP - 508
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 6
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19323364.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Winchester, Michael R.
AU - Turk, Gregory C.
AU - Butler, Therese A.
AU - Oatts, Thomas J.
AU - Coleman, Charles
AU - Nadratowski, Donald
AU - Sud, Ritu
AU - Hoover, Mark D.
AU - Stefaniak, Aleksandr B.
T1 - Certification of Beryllium Mass Fraction in SRM 1877 Beryllium Oxide Powder Using High-Performance Inductively Coupled Plasma Optical Emission Spectrometry with Exact Matching.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2009/03/15/
VL - 81
IS - 6
M3 - Article
SP - 2208
EP - 2217
SN - 00032700
AB - High-performance inductively coupled plasma optical emission spectrometry (HP-ICP-OES) was used to certify the Be mass fraction in National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 1877 Beryllium Oxide Powder. The certified value and expanded uncertainty expressed at a 95% confidence level is (0.3576 ± 0.0024) g/g. To obtain best results, the Be mass fractions, Mn (internal standard) mass fractions, and matrix compositions of the calibration solutions were carefully matched to those of the sample solutions for each individual HP-ICP-OES analysis. This "exact matching" approach was used because experience at NIST has shown that it often affords improved accuracy and precision in HP-ICP-OES analysis. NIST has never published these observations. Due to the toxicity of BeO and the difficulty of containing the very fine powder material, sets of solutions for HP-ICP-OES analysis were prepared by laboratories collaborating with NIST who have the experience and equipment needed to work with the material safely. Each laboratory utilized a unique digestion protocol(s). After preparing the sets of solutions, the collaborating laboratories shipped them to NIST for HP-ICP-OES analysis. NIST provided the collaborating laboratories with solution preparation kits and spreadsheets to help establish traceability of the HP-ICP-OES results to the International System of Units (SI) and to allow exact matching to be accomplished. The agreement observed among the four individual Be mass fraction values determined from the sets of solutions prepared by the collaborating laboratories was 0.0 74% relative (is of mean). The excellent agreement provides a measure of confidence in the robustness of each of the digestion procedures, as well as in the certified Be mass fraction value. The analytical benefits of using exact matching for this particular certification were investigated. Results show that exactly matching the matrix compositions of the standards to the samples for each HP-ICP-OES analysis was critical to obtaining the excellent agreement observed among the individual Be mass fraction values and also helped to minimize bias and uncertainly in the certified value. Unlike previous NIST studies, exactly matching the Be and Mn mass fractions of the standards to the samples for this particular certification appears to have had little effect on the data. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CERTIFICATION
KW - BERYLLIUM oxide
KW - INDUCTIVELY coupled plasma spectrometry
KW - POWDERS
KW - OPTICAL properties
KW - MASS (Physics) -- Measurement
KW - ANALYTICAL chemistry -- Technique
KW - SOLUTION (Chemistry)
KW - CALIBRATION
N1 - Accession Number: 37258328; Winchester, Michael R. 1; Email Address: mrw@nist.gov Turk, Gregory C. 1 Butler, Therese A. 1 Oatts, Thomas J. 2 Coleman, Charles 3 Nadratowski, Donald 4 Sud, Ritu 4 Hoover, Mark D. 5 Stefaniak, Aleksandr B. 5; Affiliation: 1: Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899. 2: Analytical Chemistry Organization, Y- 12 National Security Complex, Oak Ridge, Tennessee 37831-8189. 3: Savannah River Site, Building 773-A, Aiken, South Carolina 29808. 4: Bureau Veritas North America, Incorporated, 22345 Roethel Drive, Novi, Michigan 48375. 5: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888.; Source Info: 3/15/2009, Vol. 81 Issue 6, p2208; Subject Term: CERTIFICATION; Subject Term: BERYLLIUM oxide; Subject Term: INDUCTIVELY coupled plasma spectrometry; Subject Term: POWDERS; Subject Term: OPTICAL properties; Subject Term: MASS (Physics) -- Measurement; Subject Term: ANALYTICAL chemistry -- Technique; Subject Term: SOLUTION (Chemistry); Subject Term: CALIBRATION; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fisher, Edward
AU - Rengasamy, Samy
AU - Viscusi, Dennis
AU - Vo, Evanly
AU - Shaffer, Ronald
T1 - Development of a Test System To Apply Virus-Containing Particles to Filtering Facepiece Respirators for the Evaluation of Decontamination Procedures.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/03/15/
VL - 75
IS - 6
M3 - Article
SP - 1500
EP - 1507
SN - 00992240
AB - A chamber to apply aerosolized virus-containing particles to air-permeable substrates (coupons) was constructed and validated as part of a method to assess the virucidal efficacy of decontamination procedures for filtering facepiece respirators. Coliphage MS2 was used as a surrogate for pathogenic viruses for confirmation of the efficacy of the bioaerosol respirator test system. The distribution of virus applied onto and within the coupons was characterized, and the repeatability of applying a targeted virus load was examined. The average viable virus loaded onto 90 coupons over the course of 5 days was found to be 5.09 ± 0.19 log10 PFU/coupon (relative standard deviation, 4%). To determine the ability to differentiate the effectiveness of disinfecting procedures with different levels of performance, sodium hypochlorite and steam treatments were tested in experiments by varying the dose and time, respectively. The role of protective factors was assessed by aerosolizing the virus with various concentrations of the aerosol-generating medium. A sodium hypochlorite (bleach) concentration of 0.6% and steam treatments of 45 s and longer resulted in log reductions (>4 logs) which reached the detection limits for both levels of protective factors. Organic matter (ATCC medium 271) as a protective factor afforded some protection to the virus in the sodium hypochlorite experiments but was not a factor in the steam experiments. The evaluation of the bioaerosol respirator test system demonstrated a repeatable method for applying a targeted viral load onto respirator coupons and provided insight into the properties of aerosols that are of importance to the development of disinfection assays for air-permeable materials. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - PATHOGENIC microorganisms
KW - BREATHING apparatus
KW - TEST systems
KW - VIRAL load
KW - AEROSOLS (Sprays)
KW - SODIUM hypochlorite
N1 - Accession Number: 37216393; Fisher, Edward 1 Rengasamy, Samy 2 Viscusi, Dennis 2 Vo, Evanly 2 Shaffer, Ronald 2; Email Address: RShaffer@cdc.gov; Affiliation: 1: EG&G Technical Services, Inc., Pittsburgh, Pennsylvania 15236 2: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania 15236; Source Info: Mar2009, Vol. 75 Issue 6, p1500; Subject Term: VIRUSES; Subject Term: PATHOGENIC microorganisms; Subject Term: BREATHING apparatus; Subject Term: TEST systems; Subject Term: VIRAL load; Subject Term: AEROSOLS (Sprays); Subject Term: SODIUM hypochlorite; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 8p; Illustrations: 4 Graphs; Document Type: Article
L3 - 10.1128/AEM.01653-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Parveen, Salina
AU - Hettiarachchi, Kumidini A.
AU - Bowers, John C.
AU - Jones, Jessica L.
AU - Tamplin, Mark L.
AU - McKay, Rusty
AU - Beatty, William
AU - Brohawn, Kathy
AU - DaSilva, Ligia V.
AU - DePaola, Angelo
T1 - Corrigendum to “Seasonal distribution of total and pathogenic Vibrio parahaemolyticus in Chesapeake Bay oysters and waters” [Int. J. of Food Microbiol. 128 (2008) 354–361]
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/03/15/
VL - 130
IS - 1
M3 - Correction notice
SP - 75
EP - 75
SN - 01681605
N1 - Accession Number: 36474720; Parveen, Salina 1; Email Address: sparveen@umes.edu; Hettiarachchi, Kumidini A. 1; Bowers, John C. 2; Jones, Jessica L. 3; Tamplin, Mark L. 4; McKay, Rusty 5; Beatty, William 5; Brohawn, Kathy 5; DaSilva, Ligia V. 1; DePaola, Angelo 5; Affiliations: 1: Food Science and Technology Ph. D. Program, Department of Agriculture, Food and Resource Sciences, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States; 2: Division of Public Health and Biostatistics, U. S. Food and Drug Administration, College Park, Maryland 20740, United States; 3: Gulf Coast Seafood Laboratory, U. S. Food and Drug Administration, Dauphin Island, Alabama 36528, United States; 4: Food Safety Centre, University of Tasmania, Hobart, Tasmania 7001, Australia; 5: Maryland Department of the Environment, Baltimore, Maryland 21230, United States; Issue Info: Mar2009, Vol. 130 Issue 1, p75; Number of Pages: 1p; Document Type: Correction notice
L3 - 10.1016/j.ijfoodmicro.2008.09.019
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cheever, K.L.
AU - Marlow, K.L.
AU - B’Hymer, C.
AU - Hanley, K.W.
AU - Lynch, D.W.
T1 - Development of an HPLC–MS procedure for the quantification of N-acetyl-S-(n-propyl)-l-cysteine, the major urinary metabolite of 1-bromopropane in human urine
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/03/15/
VL - 877
IS - 8/9
M3 - Article
SP - 827
EP - 832
SN - 15700232
AB - Abstract: An analytical procedure was developed for the detection and quantification of N-acetyl-S-(n-propyl)-l-cysteine (n-propylmercapturic acid, AcPrCys), a metabolite and biomarker for exposure to 1-bromopropane (1-BP). 1-BP is used as an industrial solvent and exposure is a health concern for industrial workers due to its toxicity. It has been associated with neurological disorders in both animals and humans. Urine sample preparation for the determination of AcPrCys consisted of solid phase extraction (SPE). Urine samples on preconditioned SPE (C18) columns were washed with 40% methanol/60% water solution prior to elution with acetone. Quantification was by means of a liquid chromatograph (LC) equipped with a mass spectrometer (MS) using an Aqua 3μm C18 300A column and [d7]-AcPrCys was used as internal standard. Electrospray ionization (ESI) was used with the MS operated in the negative ion mode and selected ion monitoring (SIM) at m/z 204 for AcPrCys and m/z 211 for [d7]-AcPrCys. Demonstrated recovery of urine samples fortified at multiple levels (0.625–10μg/ml) varied between 96 and 103% of theory with relative standard deviations (RSD) of 6.4% or less. The limit of detection (LOD) for the procedure was approximately 0.01μg/ml AcPrCys in urine. These data will be discussed as well as other factors of the development of this test procedure. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH performance liquid chromatography
KW - MASS spectrometry
KW - URINALYSIS
KW - BROMOPROPANE
KW - ORGANIC compounds
KW - METABOLITES
KW - BIOCHEMICAL markers
KW - 1-Bromopropane
KW - HPLC–MS
N1 - Accession Number: 36899690; Cheever, K.L. 1 Marlow, K.L. 1 B’Hymer, C.; Email Address: cbhymer@cdc.gov Hanley, K.W. 1 Lynch, D.W. 1; Affiliation: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Mar2009, Vol. 877 Issue 8/9, p827; Subject Term: HIGH performance liquid chromatography; Subject Term: MASS spectrometry; Subject Term: URINALYSIS; Subject Term: BROMOPROPANE; Subject Term: ORGANIC compounds; Subject Term: METABOLITES; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: 1-Bromopropane; Author-Supplied Keyword: HPLC–MS; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.jchromb.2009.02.010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore, Matthew R.
T1 - Rethinking Replacement and Resistance.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/03/15/
VL - 199
IS - 6
M3 - Article
SP - 771
EP - 773
SN - 00221899
AB - The article provides information on the dramatic success of the bacterial agent 7-valent pneumococcal conjugate vaccine (PCV7). First introduced in 2000, PCV7 is believed to have effectively reduced the pneumococcal disease in most rich countries, and a great degree, made its way to its global introduction as it was recommended by the World Health Organization (WHO). However, when employed to nasopharyngeal colonization, PCV7 is claimed to have shown no reduction to the overall prevalence of the such disease.
KW - COMMUNICABLE diseases -- Prevention
KW - VACCINATION
KW - IMMUNIZATION
KW - COMMUNICABLE diseases
KW - PREVENTIVE medicine
KW - PUBLIC health research
KW - POPULATION health
KW - DISEASES
KW - WORLD Health Organization
N1 - Accession Number: 37035037; Moore, Matthew R. 1; Email Address: matt.moore@cdc.hhs.gov; Affiliation: 1: US Public Health Service, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: 3/15/2009, Vol. 199 Issue 6, p771; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: COMMUNICABLE diseases; Subject Term: PREVENTIVE medicine; Subject Term: PUBLIC health research; Subject Term: POPULATION health; Subject Term: DISEASES; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
L3 - 10.1086/597045
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37035037&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Muskhelishvili, Levan
AU - Tryndyak, Volodymyr P.
AU - Beland, Frederick A.
T1 - The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/03/15/
VL - 235
IS - 3
M3 - Article
SP - 305
EP - 311
SN - 0041008X
AB - Abstract: The aromatic amine 2-acetylaminofluore (2-AAF) is a powerful complete genotoxic rat liver carcinogen that induces tumors without any additional interventions. While the tumor-initiating genotoxic activity of 2-AAF is well established, its tumor-promotion activity is far less understood. It is believed that the tumor-promoting property of 2-AAF is associated with selective enhancement of cell replication and sustained suppression of apoptosis in initiated cells. In the present study, we investigated the underlying mechanisms of tumor-promoting events induced by 2-AAF-exposure. Male Sprague–Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 12 and 24 weeks, and the expression pattern of genes associated with the p53-signaling pathway and microRNA genes was determined in the livers of control and 2-AAF-fed rats. The results indicate that the tumor-promoting property of 2-AAF during hepatocarcinogenesis is associated predominantly with the up-regulation of anti-apoptotic growth-related genes and down-regulation of expression of pro-apoptotic genes. This disrupts the balance between cell proliferation and apoptosis, which leads to consequential unrestricted cell proliferation, especially of initiated cells. Also, the long-term-administration of 2-AAF resulted in disruption of regulatory miR-34a-p53 feed-back loop that mediates apoptosis. This was evidenced by an increased expression of miR-34a in response to genotoxic effects of 2-AAF in the absence of p53 up-regulation, and loss of regulatory control of mir-34a on SIRT1 function. Additionally, the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell–cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCARCINOGENS
KW - ACETYLAMINOFLUORENE
KW - P53 antioncogene
KW - CELLULAR signal transduction
KW - APOPTOSIS
KW - CELL proliferation
KW - SPRAGUE Dawley rats
KW - RATS as laboratory animals
KW - GENETIC regulation
KW - GENETIC toxicology
KW - LIVER -- Cancer
KW - 2-Acetylaminofluore
KW - Apoptosis
KW - Cell proliferation
KW - Hepatocarcinogenesis
KW - MicroRNA
KW - p53
N1 - Accession Number: 36681717; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Muskhelishvili, Levan 2 Tryndyak, Volodymyr P. 1 Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Mar2009, Vol. 235 Issue 3, p305; Subject Term: COCARCINOGENS; Subject Term: ACETYLAMINOFLUORENE; Subject Term: P53 antioncogene; Subject Term: CELLULAR signal transduction; Subject Term: APOPTOSIS; Subject Term: CELL proliferation; Subject Term: SPRAGUE Dawley rats; Subject Term: RATS as laboratory animals; Subject Term: GENETIC regulation; Subject Term: GENETIC toxicology; Subject Term: LIVER -- Cancer; Author-Supplied Keyword: 2-Acetylaminofluore; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cell proliferation; Author-Supplied Keyword: Hepatocarcinogenesis; Author-Supplied Keyword: MicroRNA; Author-Supplied Keyword: p53; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.taap.2008.12.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105097452
T1 - Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force.
AU - Wolff T
AU - Miller T
AU - Ko S
Y1 - 2009/03/17/
N1 - Accession Number: 105097452. Language: English. Entry Date: 20100924. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0372351.
KW - Aspirin -- Therapeutic Use
KW - Cardiovascular Diseases -- Prevention and Control
KW - Platelet Aggregation Inhibitors -- Therapeutic Use
KW - Age Factors
KW - Aged
KW - Aspirin -- Adverse Effects
KW - Female
KW - Gastrointestinal Hemorrhage -- Chemically Induced
KW - Male
KW - Middle Age
KW - Mortality
KW - Platelet Aggregation Inhibitors -- Adverse Effects
KW - Preventive Health Care
KW - Risk Assessment
KW - Stroke -- Chemically Induced
SP - 405
EP - 410
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 150
IS - 6
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Coronary heart disease and cerebrovascular disease are leading causes of death in the United States. In 2002, the U.S. Preventive Services Task Force (USPSTF) strongly recommended that clinicians discuss aspirin with adults who are at increased risk for coronary heart disease. PURPOSE: To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death. DATA SOURCES: MEDLINE and Cochrane Library (search dates, 1 January 2001 to 28 August 2008), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. STUDY SELECTION: English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD? Does aspirin increase gastrointestinal bleeding or hemorrhagic strokes? DATA EXTRACTION: All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. DATA SYNTHESIS: New evidence from 1 good-quality RCT, 1 good-quality meta-analysis, and 2 fair-quality subanalyses of RCTs demonstrates that aspirin use reduces the number of CVD events in patients without known CVD. Men in these studies experienced fewer myocardial infarctions and women experienced fewer ischemic strokes. Aspirin does not seem to affect CVD mortality or all-cause mortality in either men or women. The use of aspirin for primary prevention increases the risk for major bleeding events, primarily gastrointestinal bleeding events, in both men and women. Men have an increased risk for hemorrhagic strokes with aspirin use. A new RCT and meta-analysis suggest that the risk for hemorrhagic strokes in women is not statistically significantly increased. LIMITATIONS: New evidence on aspirin for the primary prevention of CVD is limited. The dose of aspirin used in the RCTs varied, which prevented the estimation of the most appropriate dose for primary prevention. Several of the RCTs were conducted within populations of health professionals, which potentially limits generalizability. CONCLUSION: Aspirin reduces the risk for myocardial infarction in men and strokes in women. Aspirin use increases the risk for serious bleeding events.
SN - 0003-4819
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA.
U2 - PMID: 19293073.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - CoIe, Leah E.
AU - Yang Yang
AU - Elkins, Karen L.
AU - Fernandez, Ellen T.
AU - Qureshi, Nilofer
AU - Shlomchik, Mark J.
AU - Herzenberg, Leonard A.
AU - Herzenberg, Leonore A.
AU - Vogel, Stefanie N.
T1 - Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2009/03/17/
VL - 106
IS - 11
M3 - Article
SP - 4343
EP - 4348
SN - 00278424
AB - Francisella tularensis (Ft), a Gram-negative intracellular bacterium. is the etiologic agent of tularemia. Infection of mice with <10 Ft Live Vaccine Strain (Ft LVS) organisms i.p. causes a lethal infection that resembles human tularemia. Here, we show that immunization with as little as 0.1 ng Ft LVS lipopolysaccharide (Ft-LPS), but not Ft lipid A, generates a rapid antibody response that protects wild-type (WT) mice against lethal Ft LVS challenge. Protection is not induced in Ft-LPS-immunized B cell-deficient mice (μMT or JhD), male xid mice, or Ig transgenic mice that produce a single IgH (not reactive with Ft-LPS). Focusing on the cellular mechanisms that underlie this protective response, we show that Ft-LPS specifically stimulates proliferation of B-la lymphocytes that bind fluorochrOme-labeled Ft-LPS and the differentiation of these cells to plasma cells that secrete antibodies specific for Ft-LPS. This exclusively B-la antibody response is equivalent in WT, T-deficient (TCRαβ[sup-/-], TCRγδ[sup-/-]), and Toll-like receptor 4 (TLR4)-deficient (TLR4[sup-/-]) mice and thus is not dependent on T cells or typical inflammatory processes. Serum antibody levels peak ≈5 days after Ft-LPS immunization and persist at low levels for months. Thus, immunization with Ft-LPS activates a rare population of antigenspecific B-la cells to produce a persistent T-independent antibody response that provides long-term protection against lethal Ft LVS infection. These data support the possibility of creating effective, minimally invasive vaccines that can provide effective protection against pathogen invasion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FRANCISELLA tularensis
KW - MICE -- Diseases
KW - TULAREMIA
KW - ENDOTOXINS
KW - LYMPHOCYTES
KW - PLASMA cells
KW - T cell receptors
N1 - Accession Number: 37343535; CoIe, Leah E. 1 Yang Yang 2 Elkins, Karen L. 3 Fernandez, Ellen T. 3 Qureshi, Nilofer 4 Shlomchik, Mark J. 5 Herzenberg, Leonard A. 2; Email Address: Ienherz@standford.edu Herzenberg, Leonore A. 2 Vogel, Stefanie N. 1; Email Address: svogel@som.umaryland.edu; Affiliation: 1: Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201 2: Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305 3: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852 4: Department of Basic Medical Science, University of Missouri, Kansas City, MO 64108 5: Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8035; Source Info: 3/17/2009, Vol. 106 Issue 11, p4343; Subject Term: FRANCISELLA tularensis; Subject Term: MICE -- Diseases; Subject Term: TULAREMIA; Subject Term: ENDOTOXINS; Subject Term: LYMPHOCYTES; Subject Term: PLASMA cells; Subject Term: T cell receptors; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shu-Ying Gao
AU - En-Min Li
AU - Lei Cui
AU - Xiao-Feng Lu
AU - Ling-Ying Meng
AU - Hua-Min Yuan
AU - Jian-Jun Xie
AU - Ze-Peng Du
AU - Jian-Xin Pang
AU - Li-Yan Xu
T1 - Sp1 and AP-1 Regulate Expression of the Human Gene, VIL2 in Esophageal Carcinoma Cells.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/03/20/
VL - 284
IS - 12
M3 - Article
SP - 7995
EP - 8004
SN - 00219258
AB - Ezrin, encoded by VIL2, is a membrane-cytoskeletal linker protein that has been suggested to be involved in tumorigenesis. Ezrin expression in esophageal squamous cell carcinoma (ESCC) was described recently, but its clinical significance and the molecular mechanism underlying its regulated expression remain unclear. Thus, we retrospectively evaluated ezrin expression by immunohistochemistry in a tissue microarray representing 193 ESCCs. Ezrin overexpression in 90 of 193 tumors (46.6%) was associated with poor survival (p = 0.048). We then explored the mechanism by which ezrin expression is controlled in ESCC by assessing the transcriptional regulatory regions of human VIL2 by fusing deletions or site-directed mutants of the 5'-flanking region of the gene to a luciferase reporter. We found that the region -87/-32 containing consensus Sp1 (751-69) and AP1 (-64/-58) binding sites is crucial for VIL2 promoter activity in esophageal carcinoma cells (EC109) derived from ESCC. AP-1 is comprised of c-Jun and c-Fos. Electrophoretic mobility shift and chromatin immunoprecipitation experiments demonstrated that Spi and c-Jun bound specifically to their respective binding sites within the VIL2 promoter. In addition, transient expression of Sp1, c-Jun, or c-Fos increased ezrin expression and VIL2 promoter activity, Use of selective inhibitors revealed that VIL2 transactivation required the MEK1/2 signal transduction pathway but not JNK or p38 MAPK. Taken together, we propose a possible signal transduction pathway whereby MEK1/2 phosphorylates ERK1/2, which phosphorylates Spi and AP-1 that in turn bind to their respective binding sites to regulate the expression of human VIL2 in ESCC cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOSKELETAL proteins
KW - CARCINOGENESIS
KW - SQUAMOUS cell carcinoma
KW - IMMUNOHISTOCHEMISTRY
KW - PROTEIN microarrays
KW - LUCIFERASES
KW - BINDING sites (Biochemistry)
N1 - Accession Number: 37354314; Shu-Ying Gao 1,2 En-Min Li 1; Email Address: nmli@stu.edu.cn Lei Cui 1 Xiao-Feng Lu 2 Ling-Ying Meng 1 Hua-Min Yuan 2 Jian-Jun Xie 1 Ze-Peng Du 1 Jian-Xin Pang 3 Li-Yan Xu 2; Email Address: liyanxu1130@yahoo.com.cn; Affiliation: 1: Department of Biochemistry and Molecular Biology, Medical College, Shantou University, Shantou 515041, USA 2: lnstitute of Oncologic Pathology, Medical College, Shantou University, Shantou 515041, USA 3: Center of Drug Evaluation and Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Source Info: 3/20/2009, Vol. 284 Issue 12, p7995; Subject Term: CYTOSKELETAL proteins; Subject Term: CARCINOGENESIS; Subject Term: SQUAMOUS cell carcinoma; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: PROTEIN microarrays; Subject Term: LUCIFERASES; Subject Term: BINDING sites (Biochemistry); Number of Pages: 10p; Illustrations: 3 Black and White Photographs, 1 Diagram, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M809734200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - McDowell, Thomas W.
AU - Welcome, Daniel E.
AU - Warren, Christopher
AU - Wu, John Z.
AU - Rakheja, Subhash
T1 - Analysis of anti-vibration gloves mechanism and evaluation methods
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2009/03/20/
VL - 321
IS - 1/2
M3 - Article
SP - 435
EP - 453
SN - 0022460X
AB - The primary objectives of the current study are to enhance the understanding of the mechanisms of the anti-vibration gloves and to evaluate the methods for assessing their vibration isolation effectiveness through developing a mechanical-equivalent model of the glove-hand–arm system. The model is developed based on the measured driving-point mechanical impedances distributed at the fingers and the palm of the hand with and without a glove. Six subjects participated in the experiments with two types of anti-vibration gloves (air-bladder glove and gel-filled glove) for measuring the required impedance data. The proposed model is applied to predict the effectiveness of the glove in terms of vibration transmitted to the fingers-glove and palm-glove interfaces, the finger bones, and the wrist. The results show that the gloves could provide some attenuation of the palm-transmitted vibration at frequencies above the fundamental resonant frequency of the gloved hand–arm system, but only little reduction in the finger vibration below the dominant finger resonant frequency. The present standardized methodology based upon the transmissibility measurement at the palm alone would thus be inappropriate for characterizing the overall reduction of the vibration exposure by a glove. Moreover, the palm adapter could introduce some measurement errors because of its mass and misalignment effects and its interference with the glove-palm coupling relationship. Therefore, the standardized method may only be used for general screening tests. On the basis of the model results, several potential improvements in the current standardized methodologies for evaluations of gloves and glove material are proposed and discussed. The proposed model may also serve as a useful tool for further developments of anti-vibration gloves and other anti-vibration devices. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GLOVES
KW - VIBRATION (Mechanics)
KW - PREVENTION
KW - COLLOIDS
KW - FREQUENCIES of oscillating systems
KW - PALM (Anatomy)
KW - FINGERS
N1 - Accession Number: 36548505; Dong, Ren G. 1; Email Address: rkd6@cdc.gov McDowell, Thomas W. 1 Welcome, Daniel E. 1 Warren, Christopher 1 Wu, John Z. 1 Rakheja, Subhash 2; Affiliation: 1: National Institute for Occupational Safety and Health, Engineering and Control Technology Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: CONCAVE Research Centre, Concordia University, 1455 de Maisonneuve, West Montréal, QC, Canada H3G 1M8; Source Info: Mar2009, Vol. 321 Issue 1/2, p435; Subject Term: GLOVES; Subject Term: VIBRATION (Mechanics); Subject Term: PREVENTION; Subject Term: COLLOIDS; Subject Term: FREQUENCIES of oscillating systems; Subject Term: PALM (Anatomy); Subject Term: FINGERS; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.jsv.2008.09.044
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vellozzi, Claudia
AU - Burwen, Dale R.
AU - Dobardzic, Azra
AU - Ball, Robert
AU - Walton, Kimp
AU - Haber, Penina
T1 - Safety of trivalent inactivated influenza vaccines in adults: Background for pandemic influenza vaccine safety monitoring
JO - Vaccine
JF - Vaccine
Y1 - 2009/03/26/
VL - 27
IS - 15
M3 - Article
SP - 2114
EP - 2120
SN - 0264410X
AB - Abstract: In preparation for pandemic vaccine safety monitoring, we assessed adverse events reported to the Vaccine Adverse Event Reporting System following receipt of trivalent inactivated influenza vaccines among adults from 1990 through 2005. We calculated reporting rates for nonserious, serious, and neurological adverse events. We reviewed reports of recurrent events and deaths, as well as reports identified through advanced signal detection. The most frequently reported events were local reactions and systemic symptoms. Guillain-Barré syndrome was the most frequently reported serious event (0.70 reports per million vaccinations). Adverse event reporting rates have been reasonably constant over time. No new safety concerns emerged after our review of 15 years of post-licensure surveillance data. These findings provide useful information if pandemic vaccine is rapidly distributed and pre-licensure data are limited. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Epidemics
KW - Vaccination
KW - HEALTH
KW - Drugs -- Safety measures
KW - Influenza
KW - Valence (Chemistry)
KW - Drug monitoring
KW - COMPLICATIONS
KW - Neurovirology
KW - Young adults
KW - cardiovascular ( CV )
KW - digestive ( DIG )
KW - endocrine ( ENDO )
KW - heme and lymphatic ( HAL )
KW - Influenza vaccines
KW - metabolic and nutritional ( MAN )
KW - musculoskeletal ( MS )
KW - nervous ( NER )
KW - Post-marketing surveillance
KW - respiratory ( RES )
KW - skin ( SKIN )
KW - special ( SS )
KW - Vaccine safety
N1 - Accession Number: 36972572; Vellozzi, Claudia 1,2; Email Address: bno1@cdc.gov; Burwen, Dale R. 3; Dobardzic, Azra 3; Ball, Robert 3; Walton, Kimp 1; Haber, Penina 1; Email Address: PHaber@cdc.gov; Affiliations: 1: Immunization Safety Office (ISO), Office of the Chief Science Officer (OCSO), Centers for Disease Control and Prevention, Atlanta, GA, United States; 2: National Center for HIV, Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, United States; 3: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Rockville, MD, United States; Issue Info: Mar2009, Vol. 27 Issue 15, p2114; Thesaurus Term: VACCINATION; Thesaurus Term: Epidemics; Thesaurus Term: Vaccination; Thesaurus Term: HEALTH; Subject Term: Drugs -- Safety measures; Subject Term: Influenza; Subject Term: Valence (Chemistry); Subject Term: Drug monitoring; Subject Term: COMPLICATIONS; Subject Term: Neurovirology; Subject Term: Young adults; Author-Supplied Keyword: cardiovascular ( CV ); Author-Supplied Keyword: digestive ( DIG ); Author-Supplied Keyword: endocrine ( ENDO ); Author-Supplied Keyword: heme and lymphatic ( HAL ); Author-Supplied Keyword: Influenza vaccines; Author-Supplied Keyword: metabolic and nutritional ( MAN ); Author-Supplied Keyword: musculoskeletal ( MS ); Author-Supplied Keyword: nervous ( NER ); Author-Supplied Keyword: Post-marketing surveillance; Author-Supplied Keyword: respiratory ( RES ); Author-Supplied Keyword: skin ( SKIN ); Author-Supplied Keyword: special ( SS ); Author-Supplied Keyword: Vaccine safety; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.01.125
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Perera, Pin-Yu
AU - Derrick, Steven C.
AU - Kolibab, Kristopher
AU - Momoi, Fumiki
AU - Yamamoto, Masafumi
AU - Morris, Sheldon L.
AU - Waldmann, Thomas A.
AU - Perera, Liyanage P.
T1 - A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice
JO - Vaccine
JF - Vaccine
Y1 - 2009/03/26/
VL - 27
IS - 15
M3 - Article
SP - 2121
EP - 2127
SN - 0264410X
AB - Abstract: Tuberculosis caused by Mycobacterium tuberculosis is responsible for nearly two million deaths every year globally. A single licensed vaccine derived from Mycobacterium bovis, bacille Calmette-Guerin (BCG) administered perinatally as a prophylactic vaccine has been in use for over 80 years and confers substantial protection against childhood tuberculous meningitis and miliary tuberculosis. However, the BCG vaccine is virtually ineffective against the adult pulmonary form of tuberculosis that is pivotal in the transmission of tuberculosis that has infected almost 33% of the global population. Thus, an effective vaccine to both prevent tuberculosis and reduce its transmission is urgently needed. We have generated a multi-valent, vectored vaccine candidate utilizing the modified virus Ankara (MVA) strain of vaccinia virus to tandemly express five antigens, ESAT6, Ag85A, Ag85B, HSP65 and Mtb39A of M. tuberculosis that have been reported to be protective individually in certain animal models together with an immunostimulatory cytokine interleukin-15 (MVA/IL-15/5Mtb). Although, immunological correlates of protection against tuberculosis in humans remain to be established, we demonstrate that our vaccine induced comparable CD4+ T cell and greater CD8+ T cell and antibody responses against M. tuberculosis in vaccinated mice in a direct comparison with the BCG vaccine and conferred protection against an aerogenic challenge of M. tuberculosis, thus warranting its further preclinical development. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Immune response
KW - Tuberculosis -- Mortality
KW - Tuberculosis
KW - Vaccinia
KW - Viral vaccines
KW - Molecular virology
KW - Interleukins
KW - Mice as laboratory animals
KW - Death -- Causes
KW - IL-15
KW - Tuberculosis
KW - Vaccines
N1 - Accession Number: 36972573; Perera, Pin-Yu 1; Derrick, Steven C. 2; Kolibab, Kristopher 2; Momoi, Fumiki 3; Yamamoto, Masafumi 3; Morris, Sheldon L. 2; Waldmann, Thomas A. 4; Perera, Liyanage P. 4; Email Address: pereral@mail.nih.gov; Affiliations: 1: Veterans Affairs Medical Center, Washington, DC 20422, USA; 2: Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA; 3: Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-Nishi Matsudo, Chiba 271-8587, Japan; 4: Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA; Issue Info: Mar2009, Vol. 27 Issue 15, p2121; Thesaurus Term: VACCINATION; Thesaurus Term: Immune response; Subject Term: Tuberculosis -- Mortality; Subject Term: Tuberculosis; Subject Term: Vaccinia; Subject Term: Viral vaccines; Subject Term: Molecular virology; Subject Term: Interleukins; Subject Term: Mice as laboratory animals; Subject Term: Death -- Causes; Author-Supplied Keyword: IL-15; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccines; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.01.132
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chipinda, Itai
AU - Anderson, Stacey E.
AU - Butterworth, Leon F.
AU - Beezhold, Donald
AU - Siegel, Paul D.
T1 - Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site
JO - Toxicology
JF - Toxicology
Y1 - 2009/03/29/
VL - 257
IS - 3
M3 - Article
SP - 113
EP - 116
SN - 0300483X
AB - Abstract: The local lymph node assay (LLNA) is widely used to identify chemicals that are contact sensitizers. The assay involves dosing mice with the chemical on both ears and pooling the superficial parotid lymph nodes for assessment of lymphocyte proliferation as a marker of sensitization. The present study explored potential reduction in animal usage by dosing one ear with the allergen and the other with vehicle-only. The respective draining lymph nodes were processed separately for tritiated thymidine (3H-TdR) incorporation. Cell proliferation in proper axillary and renal nodes, as well as in the spleen was also assessed. Cross-contamination of the chemicals from the dosed ears to other parts of the body via preening was prevented by dosing restrained animals and washing off the residual chemical with saline after 4h. Dosing the left ear with 0.02% oxazolone (OX) on unrestrained animals resulted in marked cell proliferation in its draining lymph node (stimulation index, SI=12.8) and in the lymph node draining the contra-lateral vehicle-dosed ear (SI=6), as well as the proper axillary lymph nodes (SI=3.3). Increased 3H-TdR incorporation was not observed in the renal lymph nodes (SI=1.1). Similar stimulation of cells was observed in the lymph node draining the ear contra-lateral to the 30% hexylcinnamaldehyde (HCA)-dosed ear. Increased proliferative activity was observed in contra-lateral draining lymph nodes of restrained mice demonstrating that these results cannot be attributed to cross-contamination of adjacent skin. A significant increase in proliferation of splenocytes was also observed. It is concluded that dermal application of a contact allergen, as exemplified by OX and HCA, may induce cell proliferation in the neighboring lymph nodes and spleen indicative of hapten and/or haptenated proteins diffusing through the skin to peripheral nodes and the blood to produce systemic sensitization. It is also possible that lymphatic capillaries may communicate between the left and right side of the mouse head. Thus the contra-lateral draining superficial parotid node cannot be used as a control for application of contact allergen to a single ear in a modified LLNA. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - SPLEEN -- Physiology
KW - LYMPH nodes
KW - ALLERGENS
KW - MICE as laboratory animals
KW - LYMPHOCYTES
KW - BIOCHEMICAL markers
KW - Contact sensitizer
KW - Local lymph node assay
KW - Peripheral lymph nodes
KW - Spleen
N1 - Accession Number: 36613462; Chipinda, Itai; Email Address: IChipinda@cdc.gov Anderson, Stacey E. 1 Butterworth, Leon F. 1 Beezhold, Donald 1 Siegel, Paul D. 1; Affiliation: 1: Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, United States; Source Info: Mar2009, Vol. 257 Issue 3, p113; Subject Term: CELL proliferation; Subject Term: SPLEEN -- Physiology; Subject Term: LYMPH nodes; Subject Term: ALLERGENS; Subject Term: MICE as laboratory animals; Subject Term: LYMPHOCYTES; Subject Term: BIOCHEMICAL markers; Author-Supplied Keyword: Contact sensitizer; Author-Supplied Keyword: Local lymph node assay; Author-Supplied Keyword: Peripheral lymph nodes; Author-Supplied Keyword: Spleen; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.tox.2008.12.019
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Stewart, Sandy F. C.
AU - Walsh, Donna L.
AU - Schroeder, R. Jason
T1 - Not All Mesalamine Enema Bottles Are Created Equal.
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
Y1 - 2009/04//
VL - 104
IS - 4
M3 - Letter
SP - 1068
EP - 1068
SN - 00029270
AB - A letter to the editor is presented in response to the article "Mechanical Performance of Generic and Proprietary Enema Bottles" published in the "ASME Journal of Medical Devices."
KW - LETTERS to the editor
KW - BOTTLES
N1 - Accession Number: 37278959; Stewart, Sandy F. C. 1; Email Address: sandy.stewart@fda.hhs.gov Walsh, Donna L. 1 Schroeder, R. Jason 1; Affiliation: 1: Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Apr2009, Vol. 104 Issue 4, p1068; Subject Term: LETTERS to the editor; Subject Term: BOTTLES; NAICS/Industry Codes: 326160 Plastics Bottle Manufacturing; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 423840 Industrial Supplies Merchant Wholesalers; Number of Pages: 1p; Document Type: Letter
L3 - 10.1038/ajg.2008.178
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105542279
T1 - Psychosocial care for women survivors of the tsunami disaster in India.
AU - Becker SM
Y1 - 2009/04//
N1 - Accession Number: 105542279. Language: English. Entry Date: 20090703. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Psychiatry/Psychology; Public Health; Women's Health. Instrumentation: Impact of Events Scale (IES). Grant Information: Naval Health Research Center (Grant N66001-03-D-2500 DO 0013), the Fulbright Foundation (grant 2004/V1/32), and the Ford Foundation. NLM UID: 1254074.
KW - Community Mental Health Services -- Methods
KW - Natural Disasters -- India
KW - Rehabilitation, Psychosocial
KW - Survivors -- Psychosocial Factors
KW - Women
KW - Adult
KW - Chi Square Test
KW - Control Group
KW - Education, Social Work
KW - Female
KW - Funding Source
KW - Impact of Events Scale
KW - India
KW - Middle Age
KW - Outcomes (Health Care)
KW - Pretest-Posttest Design
KW - Scales
KW - Self Assessment
KW - Social Work, Psychiatric -- Methods
KW - Stress Disorders, Post-Traumatic -- Therapy
KW - Stress, Psychological -- Therapy
KW - Support, Psychosocial
KW - Human
SP - 654
EP - 658
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - 4
CY - Washington, District of Columbia
PB - American Public Health Association
AB - OBJECTIVES: I investigated the effectiveness of Psychosocial Care, a community-based mental health initiative for survivors of the 2004 tsunami disaster in India. METHODS: Mental health teams from the National Institute of Mental Health and Neurosciences (NIMHANS) in India implemented a train-the-trainer model of psychosocial care in one of the worst tsunami-affected areas of south India. Three months of psychosocial care was provided for an intervention group of women, but not for a control group recruited from an exposed neighboring village. Impact of Event Scale (IES) scores--both total scores and scores for subscales on hypervigilance, avoidance, and intrusion--were compiled for both the intervention and control groups and used as outcome measures. RESULTS: For the intervention group, posttest total IES and subscale scores were significantly lower than pretest scores (P < .001), indicating improvement in symptoms. Posttest total IES and subscale scores were significantly lower for the intervention group than for the control group (P < .001). CONCLUSIONS: Psychosocial care is an effective mental health strategy for women survivors of disasters and should be an integral component of disaster response in resource-poor countries.
SN - 0090-0036
AD - College of Public Health, University of South Florida, Tampa 20057, USA. sbecker@hrsa.gov
U2 - PMID: 19150896.
DO - 10.2105/AJPH.2008.146571
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tuttle-Newhall, J. E.
AU - Krishnan, S. M.
AU - Levy, M. F.
AU - McBride, V.
AU - Orlowski, J. P.
AU - Sung, R. S.
T1 - Organ Donation and Utilization in the United States: 1998–2007.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2009/04//
VL - 9
IS - 4
M3 - Article
SP - 879
EP - 893
PB - Wiley-Blackwell
SN - 16006135
AB - Organ transplantation remains the only life-saving therapy for many patients with organ failure. Despite the work of the Organ Donation and Transplant Collaboratives, and the marked increases in deceased donors early in the effort, deceased donors only rose by 67 from 2006 and the number of living donors declined during the same time period. There continues to be increases in the use of organs from donors after cardiac death (DCD) and expanded criteria donors (ECD). This year has seen a major change in the way organs are offered with increased patient safety measures in those organ offers made by OPOs using DonorNet©. Unfortunately, the goals of 75% conversion rates, 3.75 organs transplanted per donor, 10% of all donors from DCD sources and 20% growth of transplant center volume have yet to be reached across all donation service areas (DSAs) and transplant centers; however, there are DSAs that have not only met, but exceeded, these goals. Changes in organ preservation techniques took place this year, partly due to expanding organ acceptance criteria and increasing numbers of ECDs and DCDs. Finally, the national transplant environment has changed in response to increased regulatory oversight and new requirements for donation and transplant provider organizations. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - MULTIPLE organ failure
KW - PLASTIC surgery
KW - DONATION of organs, tissues, etc.
KW - ORGAN donors
KW - UNITED States
KW - Deceased donor organs
KW - donation
KW - living donor transplantation
KW - organ utilization
KW - SRTR/OPTN
N1 - Accession Number: 37183950; Tuttle-Newhall, J. E. 1; Email Address: tuttl006@mc.duke.edu Krishnan, S. M. 2,3 Levy, M. F. 4 McBride, V. 5 Orlowski, J. P. 6 Sung, R. S. 3,7; Affiliation: 1: Duke University Health System, Durham, NC 2: Kidney Epidemiology and Cost Center, Ann Arbor, MI 3: Scientific Registry of Transplant Recipients, Ann Arbor, MI 4: Baylor All Saints Medical Center, Fort Worth, TX 5: Department of Health and Human Services, Health Resources and Services Administration, Rockville, MD 6: Center for Donation and Transplant, Albany, NY 7: University of Michigan, Ann Arbor, MI; Source Info: Apr2009, Vol. 9 Issue 4, p879; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: MULTIPLE organ failure; Subject Term: PLASTIC surgery; Subject Term: DONATION of organs, tissues, etc.; Subject Term: ORGAN donors; Subject Term: UNITED States; Author-Supplied Keyword: Deceased donor organs; Author-Supplied Keyword: donation; Author-Supplied Keyword: living donor transplantation; Author-Supplied Keyword: organ utilization; Author-Supplied Keyword: SRTR/OPTN; Number of Pages: 15p; Illustrations: 5 Charts, 5 Graphs; Document Type: Article
L3 - 10.1111/j.1600-6143.2009.02565.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37183950&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karbiwnyk, Christine M.
AU - Andersen, Wendy C.
AU - Turnipseed, Sherri B.
AU - Storey, Joseph M.
AU - Madson, Mark R.
AU - Miller, Keith E.
AU - Gieseker, Charles M.
AU - Miller, Ron A.
AU - Rummel, Nathan G.
AU - Reimschuessel, Renate
T1 - Determination of cyanuric acid residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography–tandem mass spectrometry
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2009/04//
VL - 637
IS - 1/2
M3 - Article
SP - 101
EP - 111
SN - 00032670
AB - Abstract: In May 2007, investigators discovered that waste material from the pet food manufacturing process contaminated with melamine (MEL) and/or cyanuric acid (CYA) had been added to hog and chicken feeds. At this time, investigators also learned that adulterated wheat gluten had been used in the manufacture of aquaculture feeds. Concern that the contaminated feed had been used in aquaculture and could enter the human food supply prompted the development of a method for the determination of CYA residues in the edible tissues of fish and shrimp. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) was employed as a sensitive technique for the analysis of CYA in catfish, tilapia, salmon, trout and shrimp tissue. CYA was extracted from ground fish or shrimp with an acetic acid solution, defatted with hexane, and isolated with a graphitic carbon black solid-phase extraction column. Residues were separated from matrix components using a porous graphitic carbon LC column, and then analyzed with electrospray ionization in negative ion mode on a triple quadrupole mass spectrometer. Selective reaction monitoring was performed on the [M−H]− m/z 128 ion resulting in the product ions m/z 85 and 42. Recoveries from catfish, tilapia and trout fortified with 10–100μgkg−1 of CYA averaged 67% with a relative standard deviation (R.S.D.) of 18% (n =107). The average method detection limit (MDL) for catfish, tilapia and trout is 3.5μgkg−1. An internal standard, 13C3-labeled CYA, was used in the salmon and shrimp extractions. Average recovery of CYA from salmon was 91% (R.S.D.=15%, n =18) with an MDL of 7.4μgkg−1. Average recovery of CYA from shrimp was 85% (R.S.D.=10%, n =13) with an MDL of 3.5μgkg−1. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD of animal origin -- Contamination
KW - PET food industry
KW - LIQUID chromatography
KW - TANDEM mass spectrometry
KW - SOLID-phase analysis
KW - ELECTROSPRAY ionization mass spectrometry
KW - Cyanuric acid
KW - Fish
KW - Liquid chromatography–tandem mass spectrometry
KW - Melamine
KW - Shrimp
N1 - Accession Number: 36972046; Karbiwnyk, Christine M. 1; Email Address: christine.karbiwnyk@fda.hhs.gov Andersen, Wendy C. 1 Turnipseed, Sherri B. 1 Storey, Joseph M. 2 Madson, Mark R. 2 Miller, Keith E. 3 Gieseker, Charles M. 4 Miller, Ron A. 4 Rummel, Nathan G. 4 Reimschuessel, Renate 4; Affiliation: 1: Animal Drugs Research Center, U.S. Food and Drug Administration, P.O. Box 25087, Denver, CO 80225-0087, USA 2: Denver District Laboratory, U.S. Food and Drug Administration, P.O. Box 25087, Denver, CO 80225-0087, USA 3: Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA 4: University of Denver, Department of Chemistry and Biochemistry, Denver, CO 80208, USA; Source Info: Apr2009, Vol. 637 Issue 1/2, p101; Subject Term: FOOD of animal origin -- Contamination; Subject Term: PET food industry; Subject Term: LIQUID chromatography; Subject Term: TANDEM mass spectrometry; Subject Term: SOLID-phase analysis; Subject Term: ELECTROSPRAY ionization mass spectrometry; Author-Supplied Keyword: Cyanuric acid; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Liquid chromatography–tandem mass spectrometry; Author-Supplied Keyword: Melamine; Author-Supplied Keyword: Shrimp; NAICS/Industry Codes: 311119 Other Animal Food Manufacturing; NAICS/Industry Codes: 418310 Agricultural feed merchant wholesalers; NAICS/Industry Codes: 311111 Dog and Cat Food Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.aca.2008.08.037
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Andersen, Wendy C.
AU - Turnipseed, Sherri B.
AU - Karbiwnyk, Christine M.
AU - Lee, Rebecca H.
AU - Clark, Susan B.
AU - Rowe, W. Douglas
AU - Madson, Mark R.
AU - Miller, Keith E.
T1 - Multiresidue method for the triphenylmethane dyes in fish: Malachite green, crystal (gentian) violet, and brilliant green
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
Y1 - 2009/04//
VL - 637
IS - 1/2
M3 - Article
SP - 279
EP - 289
SN - 00032670
AB - Abstract: Liquid chromatographic methods are presented for the quantitative and confirmatory determination of crystal violet (CV; also known as gentian violet), leucocrystal violet (LCV), brilliant green (BG), and leucobrilliant green (LBG) in catfish. LCV and LBG were oxidized to the chromic CV and BG by reaction with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and residues were measured as the combined CV±LCV and BG±LBG. These methods are extensions of published methods for malachite green (MG) analysis to allow simultaneous determination of MG, CV, and BG. Residues were extracted from muscle with ammonium acetate buffer and acetonitrile, and extracts cleaned up using dichloromethane partitioning and solid-phase extraction. Extracts were analyzed by liquid chromatography with visible detection (LC-VIS). The method was validated for catfish fortified with LCV over the range 0.25–10ngg−1 and CV at 2ngg−1. Average recoveries were 90.6% (±8.1% R.S.D., n =45) for LCV and 84.4% (±4.2% R.S.D., n =6) for CV. The average recovery for samples fortified with BG or LBG over the range 0.5–10ngg−1 was 67.2% (±14.8% R.S.D., n =31). CV and BG were confirmed in fish extracts by ion trap LC–mass spectrometry (LC–MS n ) with no discharge-atmospheric pressure chemical ionization. Average LC–MS n recoveries were 96.5, 96.6, and 70.2% for samples fortified with CV, LCV, and BG or LBG. The limits of detection for CV, BG, and MG were in the range of 0.07–0.24ngg−1 (ppb) for the two different instrumental methods. This methodology was applied to the analysis of catfish treated with CV and BG. [Copyright &y& Elsevier]
AB - Copyright of Analytica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FISH as food -- Contamination
KW - VAT dyes
KW - FEED additive residues
KW - CATFISHES
KW - LIQUID chromatography
KW - SOLID phase extraction
KW - MASS spectrometry
KW - Brilliant green
KW - Catfish
KW - Crystal violet
KW - Leuco metabolites
KW - Malachite green
N1 - Accession Number: 36972069; Andersen, Wendy C. 1; Email Address: wendy.andersen@fda.hhs.gov Turnipseed, Sherri B. 1 Karbiwnyk, Christine M. 1 Lee, Rebecca H. 2 Clark, Susan B. 2 Rowe, W. Douglas 2 Madson, Mark R. 2 Miller, Keith E. 3; Affiliation: 1: Animal Drugs Research Center, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, United States 2: Denver Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, United States 3: University of Denver, Department of Chemistry and Biochemistry, 2190 E. Iliff Avenue, Olin 202, Denver, CO 80208, United States; Source Info: Apr2009, Vol. 637 Issue 1/2, p279; Subject Term: FISH as food -- Contamination; Subject Term: VAT dyes; Subject Term: FEED additive residues; Subject Term: CATFISHES; Subject Term: LIQUID chromatography; Subject Term: SOLID phase extraction; Subject Term: MASS spectrometry; Author-Supplied Keyword: Brilliant green; Author-Supplied Keyword: Catfish; Author-Supplied Keyword: Crystal violet; Author-Supplied Keyword: Leuco metabolites; Author-Supplied Keyword: Malachite green; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.aca.2008.09.041
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - VIRJI, M. ABBAS
AU - WOSKIE, SUSAN R.
AU - WATERS, MARTHA
AU - BRUECK, SCOTT
AU - STANCESCU, DANIEL
AU - GORE, REBECCA
AU - ESTILL, CHERYL
AU - PRINCE, MARY
T1 - Agreement between Task-Based Estimates of the Full-Shift Noise Exposure and the Full-Shift Noise Dosimetry.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/04//
VL - 53
IS - 3
M3 - Article
SP - 201
EP - 214
SN - 00034878
AB - Noise assessments have been conducted using full-shift dosimetry and short-term task-based measurements. Advantages of the task-based method include the opportunity to directly identify high-noise exposure tasks and to target control measures, as well as obtain estimates of task-based full-shift exposures; however, there is little empirical evidence comparing the two methods. National Institute for Occupational Safety and Health assessed noise exposures at three industrial facilities using dosimetry and task-based methods with the objective of comparing the two strategies and assessing the degree of agreement and causes of disagreement. Eight indices of task-based full-shift exposures were created from task-based sampling using three methods to assess time-at-task (direct observation by industrial hygienist, end-of-shift worker estimates and supervisor estimates) and three methods to assign noise levels to tasks [direct measurement, arithmetic mean (AM) and geometric mean (GM)]. We assessed aspects of agreement (precision, bias and absolute agreement) using Bland–Altman plots and concordance correlation coefficient (CCC). Overall, the task-based methods worked fairly well, with mean biases less than ±2.8 dBA and precision ranges of 3.3–4.4 dBA. By all measures, task-based full-shift estimates based on supervisor assessment of time-at-task agreed most poorly with the dosimetry data. The task-based full-shift estimates based on worker estimates of time-at-task generally agreed as well as those based on direct observation. For task noise level, task-based full-shift estimates based on directly measured task agreed the best with dosimetry data, while agreement for task-based indices based on task AM or GM was variable. Overall, the task-based full-shift estimates based on direct observation task and direct measured task noise level achieved the best agreement with the dosimetry data (CCC 0.84) with 95% of their differences being within 7.4 dBA and 56% of the differences <3 dBA. For this index, a high degree of accuracy was observed (accuracy coefficient = 0.96) with major cause of disagreement arising from a lack of precision (precision coefficient = 0.88). When the measurements were classified by job characteristics, significant improvements in the degree of agreement were observed in the low job mobility, low job complexity and low job variability categories. Our data suggest that a high degree of absolute agreement can be achieved between the task-based and dosimetry-based estimates of full-shift exposures. The task-based approach that uses worker reports combined with task AM or GM levels is similar to the more time-intensive direct observation method to estimate full-shift exposures. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NOISE
KW - VERSIFICATION
KW - INDUSTRIAL hygiene
KW - ARITHMETIC
KW - GEOMETRY
KW - UNITED States
KW - accuracy
KW - agreement
KW - bias
KW - concordance correlation coefficient
KW - noise exposure
KW - precision
KW - task-based exposure assessment
N1 - Accession Number: 44395035; VIRJI, M. ABBAS 1; Email Address: mvirji@cdc.gov WOSKIE, SUSAN R. 2 WATERS, MARTHA 3 BRUECK, SCOTT 4 STANCESCU, DANIEL 5 GORE, REBECCA 2 ESTILL, CHERYL 3 PRINCE, MARY 3; Affiliation: 1: Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, MS 2800, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Department of Work Environment, University of Massachusetts Lowell, Lowell, MA 01854, USA 3: Industry Wide Studies Branch, Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA 4: Hazard Evaluation and Technical Assistance Branch, Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA 5: Office of Compensation Analysis and Support, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA; Source Info: Apr2009, Vol. 53 Issue 3, p201; Subject Term: NOISE; Subject Term: VERSIFICATION; Subject Term: INDUSTRIAL hygiene; Subject Term: ARITHMETIC; Subject Term: GEOMETRY; Subject Term: UNITED States; Author-Supplied Keyword: accuracy; Author-Supplied Keyword: agreement; Author-Supplied Keyword: bias; Author-Supplied Keyword: concordance correlation coefficient; Author-Supplied Keyword: noise exposure; Author-Supplied Keyword: precision; Author-Supplied Keyword: task-based exposure assessment; Number of Pages: 14p; Illustrations: 5 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mep010
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MCKERNAN, JOHN L.
AU - TORAASON, MARK A.
AU - FERNBACK, JOSEPH E.
AU - PETERSEN, MARTIN R.
T1 - Presence of Tungsten-Containing Fibers in Tungsten Refining and Manufacturing Processes.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/04//
VL - 53
IS - 3
M3 - Article
SP - 215
EP - 224
SN - 00034878
AB - In tungsten refining and manufacturing processes, a series of tungsten oxides are typically formed as intermediates in the production of tungsten powder. The present study was conducted to characterize airborne tungsten-containing fiber dimensions, elemental composition and concentrations in the US tungsten refining and manufacturing industry. During the course of normal employee work activities, seven personal breathing zone and 62 area air samples were collected and analyzed using National Institute for Occupational Safety and Health (NIOSH) fiber sampling and counting methods to determine dimensions, composition and airborne concentrations of fibers. Mixed models were used to identify relationships between potential determinants and airborne fiber concentrations. Results from transmission electron microscopy analyses indicated that airborne fibers with length >0.5 μm, diameter >0.01 μm and aspect ratios ≥3:1 were present on 35 of the 69 air samples collected. Overall, the airborne fibers detected had a geometric mean length ≈3 μm and diameter ≈0.3 μm. Ninety-seven percent of the airborne fibers identified were in the thoracic fraction (i.e. aerodynamic diameter ≤ 10 μm). Energy dispersive X-ray spectrometry results indicated that airborne fibers prior to the carburization process consisted primarily of tungsten and oxygen, with other elements being detected in trace quantities. Based on NIOSH fiber counting ‘B’ rules (length > 5 μm, diameter < 3 μm and aspect ratio ≥ 5:1), airborne fiber concentrations ranged from below the limit of detection to 0.085 fibers cm−3, with calcining being associated with the highest airborne concentrations. The mixed model procedure indicated that process temperature had a marginally significant relationship to airborne fiber concentration. This finding was expected since heated processes such as calcining created the highest airborne fiber concentrations. The finding of airborne tungsten-containing fibers in this occupational setting needs to be confirmed in similar settings and demonstrates the need to obtain information on the durability and associated health effects of these fibers. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TUNGSTEN
KW - MANUFACTURING processes
KW - TUNGSTEN oxides
KW - MANUFACTURING industries
KW - TRANSMISSION electron microscopy
KW - UNITED States
KW - airborne mineral fiber
KW - electron microscopy
KW - hard-metal manufacturing
KW - metal oxide whisker
KW - tungsten blue oxide
N1 - Accession Number: 44395036; MCKERNAN, JOHN L. 1; Email Address: mckernan.john@epa.gov TORAASON, MARK A. 2 FERNBACK, JOSEPH E. 2 PETERSEN, MARTIN R. 1; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA; Source Info: Apr2009, Vol. 53 Issue 3, p215; Subject Term: TUNGSTEN; Subject Term: MANUFACTURING processes; Subject Term: TUNGSTEN oxides; Subject Term: MANUFACTURING industries; Subject Term: TRANSMISSION electron microscopy; Subject Term: UNITED States; Author-Supplied Keyword: airborne mineral fiber; Author-Supplied Keyword: electron microscopy; Author-Supplied Keyword: hard-metal manufacturing; Author-Supplied Keyword: metal oxide whisker; Author-Supplied Keyword: tungsten blue oxide; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 10p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/annhyg/men078
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHEN, WEIHONG
AU - ZHUANG, ZIQING
AU - BENSON, STACEY
AU - DU, LILI
AU - YU, DAN
AU - LANDSITTEL, DOUGLAS
AU - WANG, LIMIN
AU - VISCUSI, DENNIS
AU - SHAFFER, RONALD E.
T1 - New Respirator Fit Test Panels Representing the Current Chinese Civilian Workers.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/04//
VL - 53
IS - 3
M3 - Article
SP - 297
EP - 305
SN - 00034878
AB - Respirator fit test panels provide an objective tool for selecting representative human test subjects based upon their facial characteristics for use in research, product development, testing and certification. Fit test panels were typically based upon anthropometric data such as the 1967–1968 survey of American military personnel. In this study, the objectives were to: (i) evaluate the applicability of the recently developed National Institute for Occupational Safety and Health (NIOSH) respirator fit test panels for Chinese workers and (ii) develop new respirator fit test panels using the Chinese survey data. Overall, 95% of the workers in the Chinese survey fall within the NIOSH bivariate and principal component analysis (PCA) panels, suggesting that these panels would also be appropriate for the Chinese population. However, distribution of the subject across the panels was not uniform; only 6.3% of survey participants fell into five cells of the bivariate panel and only 7.2% were found within three cells of the PCA panel. Therefore, new respirator fit test panels with subject dimensions and distributions specific to Chinese workers may be beneficial for certain applications. Two new respirator fit test panels were developed with the same techniques used to create the NIOSH panels. All measurements were weighted to match age and gender distributions of the Chinese population from the 2005 census. The bivariate approach used face length and face width measurements, and the PCA panel was developed using the first two principal components obtained from a set of 10 facial dimensions. Respirators designed to fit these Chinese worker-specific panels are also likely to accommodate >95% of Chinese workers. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORS (Medical equipment)
KW - NEW product development
KW - MILITARY personnel
KW - CHINESE
KW - EMPLOYEES
KW - ANTHROPOMETRY
KW - UNITED States
KW - civilian workers
KW - fit test panels
KW - respirator sizing
KW - respirators
N1 - Accession Number: 44395040; CHEN, WEIHONG 1; Email Address: wchen@mails.tjmu.edu.cn ZHUANG, ZIQING 2 BENSON, STACEY 3 DU, LILI 1 YU, DAN 1 LANDSITTEL, DOUGLAS 2,4 WANG, LIMIN 1 VISCUSI, DENNIS 2 SHAFFER, RONALD E. 2; Affiliation: 1: Department of Occupational and Environmental Health and MOE Key Lab of Environmental and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Lu 13, Wuhan 430030, Hubei, People's Republic of China 2: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA 15236, USA 3: EG&G Technical Services Inc., Pittsburgh, PA 15236, USA 4: Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, PA 15282, USA; Source Info: Apr2009, Vol. 53 Issue 3, p297; Subject Term: RESPIRATORS (Medical equipment); Subject Term: NEW product development; Subject Term: MILITARY personnel; Subject Term: CHINESE; Subject Term: EMPLOYEES; Subject Term: ANTHROPOMETRY; Subject Term: UNITED States; Author-Supplied Keyword: civilian workers; Author-Supplied Keyword: fit test panels; Author-Supplied Keyword: respirator sizing; Author-Supplied Keyword: respirators; NAICS/Industry Codes: 541613 Marketing Consulting Services; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 9p; Illustrations: 5 Charts, 7 Graphs; Document Type: Article
L3 - 10.1093/annhyg/men089
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105489746
T1 - Agreement between task-based estimates of the full-shift noise exposure and the full-shift noise dosimetry.
AU - Virji MA
AU - Woskie SR
AU - Waters M
AU - Brueck S
AU - Stancescu D
AU - Gore R
AU - Estill C
AU - Prince M
Y1 - 2009/04//
N1 - Accession Number: 105489746. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Industry
KW - Noise
KW - Occupational Exposure
KW - Environmental Monitoring -- Methods
KW - Job Description
KW - Observer Bias
KW - Occupational Health
KW - Task Performance and Analysis
KW - Human
SP - 201
EP - 214
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 3
PB - Oxford University Press / USA
SN - 0003-4878
AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. mvirji@cdc.gov
U2 - PMID: 19282390.
DO - annhyg/mep010
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105489738
T1 - Presence of tungsten-containing fibers in tungsten refining and manufacturing processes.
AU - McKernan JL
AU - Toraason MA
AU - Fernback JE
AU - Petersen MR
Y1 - 2009/04//
N1 - Accession Number: 105489738. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Pollutants, Occupational -- Analysis
KW - Metallurgy
KW - Metals -- Analysis
KW - Particulate Matter -- Analysis
KW - Environmental Monitoring -- Methods
KW - Models, Statistical
KW - Occupational Health
KW - Particle Size
KW - United States
SP - 215
EP - 224
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 3
PB - Oxford University Press / USA
SN - 0003-4878
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. mckernan.john@epa.gov
U2 - PMID: 19126624.
DO - annhyg/men078
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105500120
T1 - The stress of the care environment.
AU - Clancy CM
AU - Hughes RG
Y1 - 2009/04//
N1 - Accession Number: 105500120. Language: English. Entry Date: 20090619. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0372403.
KW - Nurses
KW - Stress, Occupational
KW - Bullying
KW - Disruptive Behavior
KW - Empowerment
KW - Nurse-Physician Relations
KW - Organizational Culture
KW - Professional Autonomy
KW - Teamwork
KW - Workload
SP - 751
EP - 753
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 89
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality, Rockville, MD.
U2 - PMID: 19348824.
DO - 10.1016/j.aorn.2009.03.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105500120&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - S S S Teo
T1 - Tuberculosis in the United Kingdom and Republic of Ireland.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2009/04//
VL - 94
IS - 4
M3 - Article
SP - 263
EP - 267
SN - 00039888
AB - AIMS: To describe the clinical features, diagnosis and management of children with tuberculosis in the United Kingdom and Republic of Ireland. METHODS: Cases of culture-confirmed and clinically diagnosed tuberculosis were reported to the British Paediatric Surveillance Unit from December 2003 to January 2005. RESULTS: 385 eligible cases were reported. Pulmonary disease was present in 154 (40%) children. Just over half (197, 51%) of children presented clinically and most of the remainder (166, 43%) at contact tracing. A probable source case was identified for 73/197 (36%) of the children presenting clinically. The majority (253, 66%) of children had a microbiological and/or histological investigation, and culture results were available for 240 (62%), of whom 102 (26%) were culture positive. Drug resistance was reported in 15 (0.4%) cases. 44% (128/292) of non-white children did not receive the recommended quadruple drug therapy. Seven children died. Only 57% (217) of children were managed by a paediatric subspecialist in respiratory or infectious diseases or a general paediatrician with a special interest in one of these areas. Fewer than five cases were reported from 119/143 (83%) respondents and 72 of 96 (75%) centres. CONCLUSIONS: Many paediatricians and centres see few children with tuberculosis. This may affect adherence to national guidelines. Managed clinical networks for children with tuberculosis may improve management and should be the standard of care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEDIATRIC therapy
KW - TUBERCULOSIS
KW - PEDIATRIC diagnosis
KW - LUNG diseases
N1 - Accession Number: 37048927; S S S Teo 1; Affiliation: 1: University of London, London, UK. Royal Liverpool Children’s Hospital, Liverpool, UK. Llandough Hospital, Cardiff, UK. Newcastle General Hospital, Newcastle, UK. Communicable Disease Surveillance Centre, National Public Health Service for Wales, Cardiff, UK. St George’s Hospital, London, UK. Great Ormond Street Hospital, London, UK. Health Protection Agency, Centre for Infections, London, UK. University College London, London, UK. St Bartholomew’s Hospital and Royal London Hospital, London, UK; Source Info: Apr2009, Vol. 94 Issue 4, p263; Subject Term: PEDIATRIC therapy; Subject Term: TUBERCULOSIS; Subject Term: PEDIATRIC diagnosis; Subject Term: LUNG diseases; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37048927&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ball, Robert
AU - Shadomy, Sean V.
AU - Meyer, Abbie
AU - Huber, Brigitte T.
AU - Leffell, Mary S.
AU - Zachary, Andrea
AU - Belotto, Michael
AU - Hilton, Eileen
AU - Bryant-Genevier, Marthe
AU - Schriefer, Martin E.
AU - Miller, Frederick W.
AU - Braun, M. Miles
T1 - HLA Type and Immune Response to Borrelia burgdorferi Outer Surface Protein A in People in Whom Arthritis Developed After Lyme Disease Vaccination.
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
Y1 - 2009/04//
VL - 60
IS - 4
M3 - Article
SP - 1179
EP - 1186
SN - 00043591
AB - The article discusses the study which investigated if persons with Lyme arthritis-associated HLA alleles might develop arthritis as a result of an immune reaction triggered by Borrelia burgdorferi outer space protein A. It concludes that treatment-resistant Lyme arthritis alleles were found commonly in persons who developed arthritis after vaccination for Lyme disease. The study also suggest that vaccination for Lyme disease is not a major factor in the development of arthritis in such cases.
KW - BORRELIA burgdorferi
KW - LYME disease
KW - ARTHRITIS
KW - VACCINATION -- Complications
KW - DISEASE complications
N1 - Accession Number: 38124527; Ball, Robert 1; Email Address: Robert.Balt@fda.hhs.gov Shadomy, Sean V. 1 Meyer, Abbie 2 Huber, Brigitte T. 2 Leffell, Mary S. 3 Zachary, Andrea 3 Belotto, Michael 4 Hilton, Eileen 4 Bryant-Genevier, Marthe 1 Schriefer, Martin E. 5 Miller, Frederick W. 6 Braun, M. Miles 1; Affiliation: 1: Center for Biologics Evaluation and Research, FDA, Rockville, Maryland 2: Tufts University School of Medicine, Boston, Massachusetts 3: Johns Hopkins University School of Medicine, Baltimore, Maryland 4: Biomedical Research Alliance of New York, Great Neck 5: Centers for Disease Control and Prevention, Fort Collins, Colorado 6: National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland; Source Info: Apr2009, Vol. 60 Issue 4, p1179; Subject Term: BORRELIA burgdorferi; Subject Term: LYME disease; Subject Term: ARTHRITIS; Subject Term: VACCINATION -- Complications; Subject Term: DISEASE complications; Number of Pages: 8p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1002/art.24418
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38124527&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105496873
T1 - HLA type and immune response to Borrelia burgdorferi outer surface protein a in people in whom arthritis developed after Lyme disease vaccination.
AU - Ball R
AU - Shadomy SV
AU - Meyer A
AU - Huber BT
AU - Leffell MS
AU - Zachary A
AU - Belotto M
AU - Hilton E
AU - Bryant-Genevier M
AU - Schriefer ME
AU - Miller FW
AU - Braun MM
Y1 - 2009/04//
N1 - Accession Number: 105496873. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0370605.
KW - Antigens, Surface -- Immunology
KW - Bacterial Vaccines -- Immunology
KW - Gram-Negative Bacteria -- Immunology
KW - Histocompatibility Testing
KW - Lipoproteins -- Immunology
KW - Lyme Disease -- Epidemiology
KW - Lyme Disease -- Immunology
KW - Lyme Disease
KW - Membrane Proteins -- Immunology
KW - Adult
KW - Aged
KW - Antibodies, Bacterial -- Blood
KW - Antibodies, Bacterial -- Immunology
KW - Autoimmune Diseases -- Epidemiology
KW - Autoimmune Diseases -- Immunology
KW - Autoimmune Diseases
KW - Bacterial Vaccines -- Adverse Effects
KW - Epidemiological Research
KW - Female
KW - Male
KW - Middle Age
KW - Risk Factors
KW - Human
SP - 1179
EP - 1186
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
JA - ARTHRITIS RHEUM
VL - 60
IS - 4
CY - Hoboken, New Jersey
PB - John Wiley & Sons, Inc.
AB - OBJECTIVE: To investigate whether persons with treatment-resistant Lyme arthritis-associated HLA alleles might develop arthritis as a result of an autoimmune reaction triggered by Borrelia burgdorferi outer surface protein A (OspA), the Lyme disease vaccine antigen. METHODS: Persons in whom inflammatory arthritis had developed after Lyme disease vaccine (cases) were compared with 3 control groups: 1) inflammatory arthritis but not Lyme disease vaccine (arthritis controls), 2) Lyme disease vaccine but not inflammatory arthritis (vaccine controls), and 3) neither Lyme disease vaccine nor inflammatory arthritis (normal controls). HLA-DRB1 allele typing, Western blotting for Lyme antigen, and T cell reactivity testing were performed. RESULTS: Twenty-seven cases were matched with 162 controls (54 in each control group). Odds ratios (ORs) for the presence of 1 or 2 treatment-resistant Lyme arthritis alleles were 0.8 (95% confidence interval [95% CI] 0.3-2.1), 1.6 (95% CI 0.5-4.4), and 1.75 (95% CI 0.6-5.3) in cases versus arthritis controls, vaccine controls, and normal controls, respectively. There were no significant differences in the frequency of DRB1 alleles. T cell response to OspA was similar between cases and vaccine controls, as measured using the stimulation index (OR 1.6 [95% CI 0.5-5.1]) or change in uptake of tritiated thymidine (counts per minute) (OR 0.7 [95% CI 0.2-2.3]), but cases were less likely to have IgG antibodies to OspA (OR 0.3 [95% CI 0.1-0.8]). Cases were sampled closer to the time of vaccination (median 3.59 years versus 5.48 years), and fewer cases had received 3 doses of vaccine (37% versus 93%). CONCLUSION: Treatment-resistant Lyme arthritis alleles were not found more commonly in persons who developed arthritis after Lyme disease vaccination, and immune responses to OspA were not significantly more common in arthritis cases. These results suggest that Lyme disease vaccine is not a major factor in the development of arthritis in these cases.
SN - 0004-3591
AD - Center for Biologics Evaluation and Research, FDA, Rockville, Maryland.
U2 - PMID: 19333928.
DO - 10.1002/art.24418
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105496873&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Mitchell, JR;
T1 - HRSA 340B program and patient safety and clinical pharmacy services collaborative update
CT - HRSA 340B program and patient safety and clinical pharmacy services collaborative update
JO - ASHP Summer Meeting
JF - ASHP Summer Meeting
SP - 111
AD - US Hlth Resources & Serv Adm, Off Pharm Affairs, 5600 Fishers Lane, 10C-03, Rockville, MD 20857, USA jmitchell@hrsa.gov
N1 - Accession Number: 46-20442; Language: English; Publication Type: Abstract of Meeting Presentation; Human Indicator: Yes; Section Heading: Institutional Pharmacy Practice; Toxicity
N2 - This session will describe the mission of the Officer of Pharmacy Affairs in its effort to promote access to clinically and cost-effective pharmacy services to the safety net population. In an effort to provide those services, HRSA is engaged in a bold, national effort - The Patient Safety and Clinical Pharmacy Services Collaborative - that will improve health outcomes and patient safety through the integration of clinical pharmacy services into primary care. Current teams in the Collaborative are making improvements in their systems and achieving results with the vision to spread this work to other populations and settings.
KW - ASHP meeting abstracts--Clinical pharmacy;
KW - Clinical pharmacy--services;
KW - Pharmacy services--clinical;
KW - Safety--patients;
KW - Pharmacy, institutional, hospital--patient care;
KW - Patients--safety;
KW - Patient care--pharmacy, institutional, hospital;
KW - Practice Interest Areas--Administrative Practice/Financial Mgmt/Human Resources/Emergency Preparedness; meeting presentations;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=46-20442&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Chen-An Tsai
AU - Chen, James J.
T1 - Multivariate analysis of variance test for gene set analysis.
JO - Bioinformatics
JF - Bioinformatics
Y1 - 2009/04//
VL - 25
IS - 7
M3 - Article
SP - 897
EP - 903
SN - 13674803
AB - Motivation: Gene class testing (GCT) or gene set analysis (GSA) is a statistical approach to determine whether some functionally predefined sets of genes express differently under different experimental conditions. Shortcomings of the Fisher's exact test for the overrepresentation analysis are illustrated by an example. Most alternative GSA methods are developed for data collected from two experimental conditions, and most is based on a univariate gene-by-gene test statistic or assume independence among genes in the gene set. A multivariate analysis of variance (MANOVA) approach is proposed for studies with two or more experimental conditions. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Bioinformatics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIVARIATE analysis
KW - ANALYSIS of variance
KW - GENES
KW - SET theory
KW - CORRELATION (Statistics)
KW - EXPERIMENTAL design
N1 - Accession Number: 44355792; Chen-An Tsai 1; Email Address: catsai@mail.cmu.edu.tw Chen, James J. 2; Email Address: jamesj.chen@fda.hhs.gov; Affiliation: 1: Graduate Institute of Biostatistics and Biostatistics Center, China Medical University, Taichung, Taiwan 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA; Source Info: Apr2009, Vol. 25 Issue 7, p897; Subject Term: MULTIVARIATE analysis; Subject Term: ANALYSIS of variance; Subject Term: GENES; Subject Term: SET theory; Subject Term: CORRELATION (Statistics); Subject Term: EXPERIMENTAL design; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1093/bioinformatics/btp098
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Busch, Michael
AU - Walderhaug, Mark
AU - Custer, Brian
AU - Allain, Jean-Pierre
AU - Reddy, Ravi
AU - McDonough, Brian
T1 - Risk assessment and cost-effectiveness/utility analysis
JO - Biologicals
JF - Biologicals
Y1 - 2009/04//
VL - 37
IS - 2
M3 - Article
SP - 78
EP - 87
SN - 10451056
AB - Abstract: Decision-makers at all levels of public health and transfusion medicine have always assessed the risks and benefits of their decisions. Decisions are usually guided by immediately available information and a significant amount of experience and judgment. For decisions concerning familiar situations and common problems, judgment and experience may work quite well, but this type of decision process can lack clarity and accountability. Public health challenges are changing as emerging diseases and expensive technologies complicate the decision-makers'' task, confronting the decision-maker with new problems that include multiple potential solutions. Decisions regarding polices and adoption of technologies are particularly complex in transfusion medicine due to the scope of the field, implications for public health, and legal, regulatory and public expectations regarding blood safety. To assist decision-makers, quantitative risk assessment and cost-effectiveness analysis are now being more widely applied. This set of articles will introduce risk assessment and cost-effectiveness methodologies and discuss recent applications of these methods in transfusion medicine. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DECISION making in clinical medicine
KW - RISK assessment
KW - MEDICAL care costs
KW - COST effectiveness
KW - BLOOD transfusion
KW - PUBLIC health
KW - BIOLOGICALS
KW - SAFETY measures
KW - Blood
KW - Policy making
KW - Public health
KW - Transfusions
N1 - Accession Number: 37352533; Busch, Michael 1,2; Email Address: mbusch@bloodsystems.org Walderhaug, Mark 3; Email Address: mark.walderhaug@fda.hhs.gov Custer, Brian 4,5; Email Address: bcuster@bloodsystems.org Allain, Jean-Pierre 6; Email Address: jpa1000@cam.ac.uk Reddy, Ravi 7; Email Address: Ravi.Reddy@sanbs.org.za McDonough, Brian 8; Email Address: BMcDonou@ocdus.jnj.com; Affiliation: 1: Blood Systems Research Institute, San Francisco, CA, USA 2: Dept of Laboratory Medicine, University of California, San Francisco, CA, USA 3: Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD, USA 4: Epidemiology and Health Policy Research, Blood Systems Research Institute, San Francisco, CA, USA 5: University of Washington, Pharmaceutical Outcomes Research and Policy Program, Seattle, WA, USA 6: Dept of Haematology, University of Cambridge, Cambridge, UK 7: South African National Blood Service, Johannesburg, South Africa 8: Ortho-Clinical Diagnostics, Raritan, NJ, USA; Source Info: Apr2009, Vol. 37 Issue 2, p78; Subject Term: DECISION making in clinical medicine; Subject Term: RISK assessment; Subject Term: MEDICAL care costs; Subject Term: COST effectiveness; Subject Term: BLOOD transfusion; Subject Term: PUBLIC health; Subject Term: BIOLOGICALS; Subject Term: SAFETY measures; Author-Supplied Keyword: Blood; Author-Supplied Keyword: Policy making; Author-Supplied Keyword: Public health; Author-Supplied Keyword: Transfusions; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.01.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37352533&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Epstein, Jay
AU - Seitz, Rainer
AU - Dhingra, Neelam
AU - Ganz, Peter R.
AU - Gharehbaghian, Ahmad
AU - Spindel, Renato
AU - Teo, Diana
AU - Reddy, Ravi
T1 - Role of regulatory agencies
JO - Biologicals
JF - Biologicals
Y1 - 2009/04//
VL - 37
IS - 2
M3 - Article
SP - 94
EP - 102
SN - 10451056
AB - Abstract: In this paper the authors discuss the role of regulation in assuring blood safety. After an overview of the subject by a leading expert, examples are provided of regulatory systems for blood transfusion services in several countries and regions. Additionally, the perspective of WHO is given on the essential role of national regulatory authorities in assuring the quality of national blood programmes. Collectively, the sections of this paper afford an opportunity for readers to make comparisons among different regulatory frameworks and to "benchmark" among the existing systems. Despite many differences in approach, a clear pattern emerges of worldwide efforts to strengthen blood regulatory systems. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GOVERNMENT agencies
KW - HEALTH care reform
KW - BLOOD transfusion
KW - HEALTH promotion
KW - BIOLOGICALS
KW - SAFETY measures
KW - Blood regulation
KW - Public health
KW - Reform
KW - WHO
KW - WORLD Health Organization
N1 - Accession Number: 37352535; Epstein, Jay 1; Email Address: jay.epstein@fda.hhs.gov Seitz, Rainer 2 Dhingra, Neelam 3 Ganz, Peter R. 4 Gharehbaghian, Ahmad 5 Spindel, Renato 6 Teo, Diana 7 Reddy, Ravi 8; Affiliation: 1: Food and Drug Administration, Rockville, MD, USA 2: Paul-Ehrlich-Institut, Langen, Germany 3: WHO Headquarters, Geneva, Switzerland 4: Centre for Biologics Evaluation, Health Canada, Ottawa, Ontario, Canada 5: Iranian Blood Transfusion Organization (IBTO) Research Center, Tehran, Iran 6: Gerencia Geral de Sangue, Outros Tecidos, Células e Órgãos (GGSTO)/Agência Nacional Vigilância Sanitária (ANVISA), Brazil 7: Health Sciences Authority, Republic of Singapore 8: South African National Blood Transfusion Service, Cape Town, South Africa; Source Info: Apr2009, Vol. 37 Issue 2, p94; Subject Term: GOVERNMENT agencies; Subject Term: HEALTH care reform; Subject Term: BLOOD transfusion; Subject Term: HEALTH promotion; Subject Term: BIOLOGICALS; Subject Term: SAFETY measures; Author-Supplied Keyword: Blood regulation; Author-Supplied Keyword: Public health; Author-Supplied Keyword: Reform; Author-Supplied Keyword: WHO; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 921190 Other General Government Support; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.01.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37352535&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Associations between Polymorphisms in DNA Repair Genes and Glioblastoma.
AU - McKean-Cowdin, Roberta
AU - Barnholtz-Sloan, Jill
AU - Inskip, Peter D.
AU - Ruder, Avima M.
AU - Butler, MaryAnn
AU - Rajaraman, Preetha
AU - Razavi, Pedram
AU - Patoka, Joe
AU - Wiencke, John K.
AU - Bondy, Melissa L.
AU - Wrensch, Margaret
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2009/04//
VL - 18
IS - 4
SP - 1118
EP - 1126
SN - 10559965
N1 - Accession Number: 38715559; Author: McKean-Cowdin, Roberta: 1 email: mckeanco@usc.edu. Author: Barnholtz-Sloan, Jill: 2 Author: Inskip, Peter D.: 3 Author: Ruder, Avima M.: 4 Author: Butler, MaryAnn: 4 Author: Rajaraman, Preetha: 3 Author: Razavi, Pedram: 1 Author: Patoka, Joe: 5 Author: Wiencke, John K.: 5 Author: Bondy, Melissa L.: 6 Author: Wrensch, Margaret: 5 ; Author Affiliation: 1 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California: 2 Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio: 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland: 4 National Institute for Occupational Safety and Health, Cincinnati, Ohio: 5 Department of Neurological Surgery, University of California, San Francisco, San Francisco, California: 6 University of Texas M. D. Anderson Cancer Center, Houston, Texas; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20090504
N2 - The article presents a study that examines the association between polymorphisms in DNA repair genes and glioblastoma multiforme, the most common and deadliest form of adult brain tumors. In this study, 12 DNA repair single-nucleotide polymorphisms were investigated. It suggests that common variation in DNA repair genes may be associated with risk for glioblastoma multiforme.
KW - *TUMORS
KW - MEDICAL research
KW - GENETIC polymorphisms
KW - DNA repair
KW - GLIOBLASTOMA multiforme
KW - BRAIN tumors
KW - RISK factors
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=s3h&AN=38715559&site=ehost-live&scope=site
DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
T1 - Ductal Lavage in Women from BRCA1/2 Families: Is There a Future for Ductal Lavage in Women at Increased Genetic Risk of Breast Cancer?
AU - Loud, Jennifer T.
AU - Thiébaut, Anne C. M.
AU - Abati, Andrea D.
AU - Filie, Armando C.
AU - Nichols, Kathryn
AU - Danforth, David
AU - Giusti, Ruthann
AU - Prindiville, Sheila A.
AU - Greene, Mark H.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2009/04//
VL - 18
IS - 4
SP - 1243
EP - 1251
SN - 10559965
N1 - Accession Number: 38715577; Author: Loud, Jennifer T.: 1 email: LoudJ@mail.nih.gov. Author: Thiébaut, Anne C. M.: 2 Author: Abati, Andrea D.: 3 Author: Filie, Armando C.: 3 Author: Nichols, Kathryn: 4 Author: Danforth, David: 3 Author: Giusti, Ruthann: 5 Author: Prindiville, Sheila A.: 6 Author: Greene, Mark H.: 1 ; Author Affiliation: 1 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland: 2 INSERM, U657, Pasteur Institute, Paris, France: 3 Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland: 4 Westat Corporation: 5 Center for Biologics Evaluation and Research, Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland: 6 Office of the Director, National Cancer Institute, NIH, Bethesda, Maryland; No. of Pages: 9; Language: English; Publication Type: Article; Update Code: 20090504
N2 - The article presents a study determining the prevalence of women's ductal lavage from BRCA1/2 families. Methods used in the study were Fisher's exact test, Wilcoxon nonparametric test, and logistic regression in distinguishing the nipple aspirate fluid (NAF)-associated variables. Results indicate the increasing probability of ductal lavage cell count in women who undergoes breast-feeding, show NAF presence, and being premenopausal.
KW - *WOMEN
KW - IRRIGATION (Medicine)
KW - BRCA genes
KW - FLOW cytometry
KW - LOGISTIC regression analysis
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Jingzhou Yang
AU - Jichang Dai
AU - Ziqing Zhuang
T1 - Simulating the Interaction between a Respirator and a Headform Using LS-DYNA.
JO - Computer-Aided Design & Applications
JF - Computer-Aided Design & Applications
Y1 - 2009/04//
VL - 6
IS - 4
M3 - Article
SP - 539
EP - 551
SN - 16864360
AB - Respirator use is an integral part of occupational safety and health practice. The challenge is to design respirators with the best fit and highest comfort level for all workers of diverse anthropometry. This paper presents a method to simulate the interaction between a respirator and a headform, and solutions for the universal design of respirators. Three-dimensional digital headforms and respirators are obtained using reverse engineering techniques. The commercial software, LS-DYNA, is used to model and simulate the interaction between a respirator and headform to determine the key factors that affect respirator fit and comfort. Both the respirator and headform are modeled as shell elements and are deformable. The results show that strap forces play an important role in pressure distribution on the face. [ABSTRACT FROM AUTHOR]
AB - Copyright of Computer-Aided Design & Applications is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREATHING apparatus
KW - RESPIRATORS (Medical equipment)
KW - PHYSICAL anthropology
KW - BIOMETRY
KW - BIOMEDICAL engineering
KW - finite element analysis
KW - headform
KW - respirator fit
KW - stress and deformation
N1 - Accession Number: 43517282; Jingzhou Yang 1; Email Address: james.yang@ttu.edu; Jichang Dai 1; Email Address: jichang.dai@ttu.edu; Ziqing Zhuang 2; Email Address: zaz3@cdc.gov; Affiliations: 1: Texas Tech University; 2: National Institute for Occupational Safety and Health; Issue Info: 2009, Vol. 6 Issue 4, p539; Thesaurus Term: BREATHING apparatus; Subject Term: RESPIRATORS (Medical equipment); Subject Term: PHYSICAL anthropology; Subject Term: BIOMETRY; Subject Term: BIOMEDICAL engineering; Author-Supplied Keyword: finite element analysis; Author-Supplied Keyword: headform; Author-Supplied Keyword: respirator fit; Author-Supplied Keyword: stress and deformation; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 13p; Illustrations: 32 Color Photographs, 2 Black and White Photographs, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.3722/cadaps.2009.539-551
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=43517282&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - An, Susun
AU - Seoyoung Kim
AU - Yong Huh
AU - Tae Ryong Lee
AU - Han-Kon Kim
AU - Park, Kui-Lea
AU - Hee Chul Eun
T1 - Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
JO - Contact Dermatitis (01051873)
JF - Contact Dermatitis (01051873)
Y1 - 2009/04//
VL - 60
IS - 4
M3 - Article
SP - 185
EP - 192
PB - Wiley-Blackwell
SN - 01051873
AB - Background: Evaluation of skin sensitization potential is an important part of the safety assessment of cosmetic ingredients and topical drugs. Recently, evaluation of changes in surface marker expression induced in dendritic cells (DC) or DC surrogate cell lines following exposure to chemicals represents one approach for in vitro test methods. Objective: The study aimed to test the change of expression patterns of surface markers on THP-1 cells by chemicals as a predictive in vitro method for contact sensitization. Methods: We investigated the expression of CD54, CD86, CD83, CD80, and CD40 after a 1-day exposure to sensitizers (1-chloro-2,4-dinitrobenzene; 2,4-dinitrofluorobenzene; benzocaine; 5-chloro-2-methyl-4-isothiazolin-3-one; hexyl cinnamic aldehyde; eugenol; nickel sulfate hexahydrate; potassium dichromate; cobalt sulfate; 2-mercaptobenzothiazole; and ammonium tetrachloroplatinate) and non-sensitizers (sodium lauryl sulfate, benzalkonium chloride, lactic acid, salicylic acid, isopropanol, and dimethyl sulphoxide). The test concentrations were 0.1×, 0.5×, and 1× of the 50% inhibitory concentration, and the relative fluorescence intensity was used as an expression indicator. Result and Conclusion: By evaluating the expression patterns of CD54, CD86, and CD40, we could classify the chemicals as sensitizers or non-sensitizers, but CD80 and CD83 showed non-specific patterns of expression. These data suggest that the THP-1 cells are good model for screening contact sensitizers and CD40 could be a useful marker complementary to CD54 and CD86. [ABSTRACT FROM AUTHOR]
AB - Copyright of Contact Dermatitis (01051873) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFER factor (Immunology)
KW - CELL surface antigens
KW - DENDRITIC cells
KW - CELL lines
KW - DERMATOLOGIC agents
KW - CD40
KW - CD54
KW - CD80
KW - CD83
KW - CD86
KW - in vitro skin sensitization
KW - THP-1 cell line
N1 - Accession Number: 37183922; An, Susun 1,2 Seoyoung Kim 1 Yong Huh 3 Tae Ryong Lee 1 Han-Kon Kim 1 Park, Kui-Lea 4 Hee Chul Eun 2; Email Address: hceun@snu.ac.kr; Affiliation: 1: AmorePacific Corporation R&D Center, Yongin-si 2: Department of Dermatology, Seoul National University College of Medicine, Seoul 3: Catholic University of Daegu, Kyongsan-si 4: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea; Source Info: Apr2009, Vol. 60 Issue 4, p185; Subject Term: TRANSFER factor (Immunology); Subject Term: CELL surface antigens; Subject Term: DENDRITIC cells; Subject Term: CELL lines; Subject Term: DERMATOLOGIC agents; Author-Supplied Keyword: CD40; Author-Supplied Keyword: CD54; Author-Supplied Keyword: CD80; Author-Supplied Keyword: CD83; Author-Supplied Keyword: CD86; Author-Supplied Keyword: in vitro skin sensitization; Author-Supplied Keyword: THP-1 cell line; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1600-0536.2009.01528.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37183922&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Stelma, F. F.
AU - Smismans, A.
AU - Goossens, V. J.
AU - Bruggeman, C. A.
AU - Hoebe, C. J. P. A.
T1 - Occupational risk of human Cytomegalovirus and Parvovirus B19 infection in female day care personnel in the Netherlands; a study based on seroprevalence.
JO - European Journal of Clinical Microbiology & Infectious Diseases
JF - European Journal of Clinical Microbiology & Infectious Diseases
Y1 - 2009/04//
VL - 28
IS - 4
M3 - Article
SP - 393
EP - 397
SN - 09349723
AB - Cytomegalovirus (CMV) and Parvovirus B19 infections acquired during pregnancy may result in developmental disabilities of the foetus. This study evaluates the occupational risk of these infections in female day care personnel. IgG seroprevalence was determined in 310 Dutch day care workers and 158 nursing school students. CMV seroprevalence was age-related, starting at 21% in those <20 years and reaching 65% in those >35 years. Between the ages of 20 and 24 years the CMV prevalence was higher in day care personnel than in controls, 50% versus 31% ( p = 0.03). In the first 2 years of employment the risk of attracting CMV was significantly increased (ORadj = 3.80; p < 0.001) and the occupational risk was also increased (ORadj 2.19; p < 0.001). Parvovirus seropositivity (71–77%) was not related to age or working at a day care centre. In conclusion, an occupational risk was observed for CMV, but not for Parvovirus infection in female day care personnel. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Clinical Microbiology & Infectious Diseases is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INDUSTRIAL safety
KW - DAY care centers -- Employees
KW - HIGH-risk pregnancy
KW - CYTOMEGALOVIRUS diseases
KW - PARVOVIRUS diseases
KW - FETUS -- Abnormalities
KW - SEROLOGY
KW - DISEASE prevalence
KW - NETHERLANDS
N1 - Accession Number: 37254505; Stelma, F. F. 1; Email Address: fstel@lmib.azm.nl Smismans, A. 1 Goossens, V. J. 1 Bruggeman, C. A. 1 Hoebe, C. J. P. A. 1,2; Affiliation: 1: Department Medical Microbiology, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands 2: Department of Infectious Diseases, South Limburg Public Health Service, Geleen, The Netherlands; Source Info: Apr2009, Vol. 28 Issue 4, p393; Subject Term: INDUSTRIAL safety; Subject Term: DAY care centers -- Employees; Subject Term: HIGH-risk pregnancy; Subject Term: CYTOMEGALOVIRUS diseases; Subject Term: PARVOVIRUS diseases; Subject Term: FETUS -- Abnormalities; Subject Term: SEROLOGY; Subject Term: DISEASE prevalence; Subject Term: NETHERLANDS; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1007/s10096-008-0635-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Litton, Charles D.
T1 - Laboratory evaluation of smoke detectors for use in underground mines
JO - Fire Safety Journal
JF - Fire Safety Journal
Y1 - 2009/04//
VL - 44
IS - 3
M3 - Article
SP - 387
EP - 393
SN - 03797112
AB - Abstract: Laboratory experiments were conducted to determine the responses of a prototype smoke detector and a commercially available photoelectric smoke detector to smoke particles generated from various combustion sources. The prototype smoke detector combines optical scattering measurements with ionization chamber measurements in order to reduce/eliminate nuisance alarms due to the presence of airborne dusts or diesel exhaust particles. The commercially available smoke detector is designed for use in harsh environments where airborne dust represents a major problem due to both nuisance alarms and detector contamination. In the experiments, the responses of the two detectors were measured when exposed to smoke particles from the exhaust of a diesel engine and from a variety of fire sources, including wood, coal, styrene butadiene rubber, and No. 2 diesel fuel. For the solid fuels, data were obtained for both smoldering and flaming combustions. This report describes the experiments, their results, and the use of these results as they apply to early-warning fire sensors capable of the rapid and reliable detection of fires in atmospheres that may or may not be contaminated by either airborne dust or the products produced from diesel engines. [Copyright &y& Elsevier]
AB - Copyright of Fire Safety Journal is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fire detectors
KW - Mine fires
KW - Photoelectricity
KW - Diesel motors
KW - Detection
KW - Fire
KW - Sensors
KW - Smoke
N1 - Accession Number: 36477607; Litton, Charles D. 1; Email Address: chl3@cdc.gov; Affiliations: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory/Disaster Prevention and Response Branch, Box 626, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Apr2009, Vol. 44 Issue 3, p387; Subject Term: Fire detectors; Subject Term: Mine fires; Subject Term: Photoelectricity; Subject Term: Diesel motors; Author-Supplied Keyword: Detection; Author-Supplied Keyword: Fire; Author-Supplied Keyword: Sensors; Author-Supplied Keyword: Smoke; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 333618 Other Engine Equipment Manufacturing; NAICS/Industry Codes: 238210 Electrical Contractors and Other Wiring Installation Contractors; NAICS/Industry Codes: 423620 Household Appliances, Electric Housewares, and Consumer Electronics Merchant Wholesalers; NAICS/Industry Codes: 414220 Household appliance merchant wholesalers; NAICS/Industry Codes: 334290 Other Communications Equipment Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.firesaf.2008.08.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36477607&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sprando, Robert L.
AU - Olejnik, Nicholas
AU - Cinar, Hediye Nese
AU - Ferguson, Martine
T1 - A method to rank order water soluble compounds according to their toxicity using Caenorhabditis elegans, a Complex Object Parametric Analyzer and Sorter, and axenic liquid media
JO - Food & Chemical Toxicology
JF - Food & Chemical Toxicology
Y1 - 2009/04//
VL - 47
IS - 4
M3 - Article
SP - 722
EP - 728
SN - 02786915
AB - Abstract: Complex Object Parametric Analyzer and Sorter (COPAS) parameters Time of Flight (TOF) and Extinction (EXT) were utilized to assess growth and development in Caenorhabditis elegans exposed to (in order of decreasing toxicity) sodium arsenite, sodium fluoride, caffeine, valproic acid, sodium borate or DMSO in C. elegans Habitation Medium (CeHM) for 72h. Using multivariate statistical modeling and unique sub sampling procedures mean p-value ratios were calculated for each compound. Comparison of mean p-value ratios and/or the percent change in mean-p value ratios to controls were utilized to assess test compound toxicity. Using this assay 5 of the 6 compounds tested (83.3%) were correctly ranked according to their toxicity based on oral rat LD50 data. Test compounds were ranked from most toxic to least toxic as follows: sodium arsenite, sodium fluoride, sodium borate, valproic acid, caffeine and DMSO. Sodium borate was found to be more toxic than caffeine and valproic acid in this bioassay. This study suggests that axenic liquid culture may be used to expose large numbers of nematodes to water soluble toxicants and the COPAS parameters TOF and EXT may be used as functional biomarkers to assess a toxin’s effect on growth and development in C. elegans. [Copyright &y& Elsevier]
AB - Copyright of Food & Chemical Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Toxicology
KW - Animal models in research
KW - Toxicity testing
KW - Dimethyl sulfoxide
KW - Caenorhabditis
KW - LSD (Drug)
KW - Valproic acid
KW - Multivariate analysis
KW - Rats as laboratory animals
KW - Alternative animal models
KW - Axenic media
KW - Caenorhabditis elegans
KW - COPAS
N1 - Accession Number: 36772234; Sprando, Robert L. 1; Email Address: Robert.sprando@fda.hhs.gov; Olejnik, Nicholas 1; Cinar, Hediye Nese 2; Ferguson, Martine 3; Affiliations: 1: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkrik Road, Laural, MD 20708, United States; 2: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Virulence Assessment, United States; 3: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Defense, Communication and Emergency Response, Division of Public Health and Biostatistics, United States; Issue Info: Apr2009, Vol. 47 Issue 4, p722; Thesaurus Term: Food -- Toxicology; Thesaurus Term: Animal models in research; Thesaurus Term: Toxicity testing; Thesaurus Term: Dimethyl sulfoxide; Subject Term: Caenorhabditis; Subject Term: LSD (Drug); Subject Term: Valproic acid; Subject Term: Multivariate analysis; Subject Term: Rats as laboratory animals; Author-Supplied Keyword: Alternative animal models; Author-Supplied Keyword: Axenic media; Author-Supplied Keyword: Caenorhabditis elegans; Author-Supplied Keyword: COPAS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.fct.2009.01.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36772234&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Khan, Saeed A.
AU - Sung, Kidon
AU - Nawaz, Mohamed S.
AU - Cerniglia, Carl E.
AU - Tamplin, Mark L.
AU - Phillips, Robert W.
AU - Kelley, Lynda Collins
T1 - The survivability of Bacillus anthracis (Sterne strain) in processed liquid eggs
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009/04//
VL - 26
IS - 2
M3 - Article
SP - 123
EP - 127
SN - 07400020
AB - Abstract: In this study, we investigated the survival and inactivation kinetics of a surrogate strain of Bacillus anthracis (Sterne strain) in whole egg (WE), egg white (EW), sugared egg yolk (YSU), and salted egg yolk (YSA) at low (−20, 0, and 5°C), moderate (15, 20, 25, 30, 35, and 40°C), and high storage temperatures (45, 50, 55, and 60°C). Outgrowth of the spores was measured as lag phase duration (LPD). Replication of vegetative cells was measured in terms of growth rate (GR) and maximum population density (MPD). Spore inactivation was recorded as inactivation rate and percent reduction in viable count. In general, spore viability decreased at low and high temperatures and increased at moderate temperatures. At 0 and 5°C, a 60–100% reduction in spore viability was seen within 2–3weeks in WE and YSU, 0–30% in YSA, and 50–100% in EW. At −20°C, however, no drop in spore titer was observed in YSU and EW but a 20% drop in titer was seen in YSA and 50% in WE within 2–3weeks. At high temperatures, WE, EW, and YSA produced a 20–50% drop in the spore titer within 1–4h whereas YSU showed 100% inactivation within 0.75h. At moderate storage temperatures, as the temperature increased from 15 to 40°C, LPD decreased from 13.5 to 0.75h and MPD reached 0.27–2.2×109 CFU/ml in YSU and WE, respectively. Markedly lower growth was observed in YSA (LPD=24–270h, MPD=9×105 CFU/ml) and spores were inactivated completely within 1–6h in EW. The survivability and inactivation data of B. anthracis in liquid egg products reported in this investigation will be helpful in developing risk assessment models on food biosecurity. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BACILLUS anthracis
KW - BACILLUS (Bacteria)
KW - HIGH temperatures
KW - COLD (Temperature)
KW - Bacillus anthracis
KW - Liquid eggs
KW - Lysozyme
KW - Model
KW - Spore
KW - Vegetative cells
N1 - Accession Number: 36248961; Khan, Saeed A. 1; Email Address: saeed.khan@fda.hhs.gov Sung, Kidon 1 Nawaz, Mohamed S. 1 Cerniglia, Carl E. 1 Tamplin, Mark L. 2 Phillips, Robert W. 3 Kelley, Lynda Collins 3; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Australian Food Safety Centre of Excellence, University of Tasmania, Hobart, TAS 7001, Australia 3: US Department of Agriculture (USDA), Russell Research Center (RRC), Athens, GA, USA; Source Info: Apr2009, Vol. 26 Issue 2, p123; Subject Term: BACILLUS anthracis; Subject Term: BACILLUS (Bacteria); Subject Term: HIGH temperatures; Subject Term: COLD (Temperature); Author-Supplied Keyword: Bacillus anthracis; Author-Supplied Keyword: Liquid eggs; Author-Supplied Keyword: Lysozyme; Author-Supplied Keyword: Model; Author-Supplied Keyword: Spore; Author-Supplied Keyword: Vegetative cells; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.fm.2008.10.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36248961&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zimliki, Charles L.
AU - Chenault, V. Michelle
AU - Mears, David
T1 - Glucose-dependent and -independent electrical activity in islets of Langerhans of Psammomys obesus, an animal model of nutritionally induced obesity and diabetes
JO - General & Comparative Endocrinology
JF - General & Comparative Endocrinology
Y1 - 2009/04//
VL - 161
IS - 2
M3 - Article
SP - 193
EP - 201
SN - 00166480
AB - Abstract: Glucose-induced insulin secretion from pancreatic β-cells involves metabolism-induced membrane depolarization and voltage-dependent Ca2+ influx. The electrical events in β-cell glucose sensing have been studied intensely using mouse islets of Langerhans, but data from other species, including models of type 2 diabetes mellitus (T2DM), are lacking. In this work, we made intracellular recordings of electrical activity from cells within islets of the gerbil Psammomys obesus (fat sand rat), a model of dietary-induced T2DM. Most islet cells from lean, non-diabetic sand rats displayed glucose-induced, KATP channel-dependent, oscillatory electrical activity that was similar to the classic “bursting” pattern of mouse β-cells. However, the oscillations were slower in sand rat islets, and the dose–response curve of electrical activity versus glucose concentration was left-shifted. Of the non-bursting cells, some produced action potentials continuously, while others displayed electrical activity that was largely independent of glucose. The latter activity consisted of continuous or intermittent action potential firing, and persisted for long periods in the absence of glucose. The glucose-insensitive activity was suppressed by diazoxide, indicating that the cells expressed KATP channels. Sand rat islets produced intracellular Ca2+ oscillations reminiscent of the oscillatory electrical pattern observed in most cells, albeit with a longer period. Finally, we found that the glucose dependence of insulin secretion from sand rat islets closely paralleled that of the bursting electrical activity. We conclude that while subpopulations of KATP-expressing cells in sand rat islets display heterogeneous electrical responses to glucose, insulin secretion most closely follows the oscillatory activity. The ease of recording membrane potential from sand rat islets makes this a useful model for studies of β-cell electrical signaling during the development of T2DM. [Copyright &y& Elsevier]
AB - Copyright of General & Comparative Endocrinology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PANCREATIC beta cells
KW - ELECTROPHYSIOLOGY
KW - GLUCOSE
KW - OBESITY
KW - DIABETES
KW - INSULIN
KW - ANIMAL models in research
KW - Calcium
KW - Electrophysiology
KW - Insulin
KW - Oscillation
KW - Pancreatic β-cell
KW - Sand rat
N1 - Accession Number: 36967569; Zimliki, Charles L. 1,2 Chenault, V. Michelle 1,2 Mears, David 1,3; Email Address: dmears@usuhs.mil; Affiliation: 1: Department of Anatomy, Physiology & Genetics, Uniformed Services University School of Medicine, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA 2: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20850, USA 3: CEMC, Faculty of Medicine, University of Chile, Santiago, Chile; Source Info: Apr2009, Vol. 161 Issue 2, p193; Subject Term: PANCREATIC beta cells; Subject Term: ELECTROPHYSIOLOGY; Subject Term: GLUCOSE; Subject Term: OBESITY; Subject Term: DIABETES; Subject Term: INSULIN; Subject Term: ANIMAL models in research; Author-Supplied Keyword: Calcium; Author-Supplied Keyword: Electrophysiology; Author-Supplied Keyword: Insulin; Author-Supplied Keyword: Oscillation; Author-Supplied Keyword: Pancreatic β-cell; Author-Supplied Keyword: Sand rat; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.ygcen.2008.12.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36967569&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105502752
T1 - The national nursing assistant survey: improving the evidence base for policy initiatives to strengthen the certified nursing assistant workforce.
AU - Squillace MR
AU - Remsburg RE
AU - Harris-Kojetin LD
AU - Bercovitz A
AU - Rosenoff E
AU - Han B
Y1 - 2009/04//
N1 - Accession Number: 105502752. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Gerontologic Care. NLM UID: 0375327.
KW - Certification
KW - Nursing Assistants -- Standards
KW - Policy Making
KW - Adult
KW - Female
KW - Interviews
KW - Male
KW - Middle Age
KW - Nursing Homes
KW - Surveys
KW - United States
KW - Human
SP - 185
EP - 197
JO - Gerontologist
JF - Gerontologist
JA - GERONTOLOGIST
VL - 49
IS - 2
PB - Oxford University Press / USA
SN - 0016-9013
AD - Disability, Aging and Long-Term Care Policy, Office of the Secretary/Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services, 200 Independence Avenue, S.W., Room 424.E20, Washington, DC 20201. marie.squillace@hhs.gov.
U2 - PMID: 19363014.
DO - geront/gnp024
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Coffey, Christopher C.
AU - Hudnall, Judith B.
AU - Martin Jr., Stephen B.
T1 - Improving the Environmental Controls at a Homeless Shelter to Assist in Reducing the Probability of Airborne Transmission of Mycobacterium tuberculosis: A Case Study.
JO - Indoor & Built Environment
JF - Indoor & Built Environment
Y1 - 2009/04//
VL - 18
IS - 2
M3 - Article
SP - 168
EP - 182
SN - 1420326X
AB - This study describes a survey of environmental controls conducted by the National Institute for Occupational Safety and Health (NIOSH) at the Salvation Army Harbor Light Center homeless shelter in the City of St. Louis, Missouri. The Missouri Department of Health and Senior Services (MO DHHS) had epidemiologically linked 19 cases of active tuberculosis (TB) to the shelter. MO DHSS requested NIOSH to determine whether improvements could be made to the environmental controls to help reduce the probability of airborne transmission of TB at the shelter. NIOSH investigators conducted thorough inspections of the shelter's air-handling units (AHUs) and evaluated airflow rates. NIOSH recommended higher efficiency filters be used in the AHUs and installation of ultraviolet lights. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor & Built Environment is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Environmental engineering
KW - Environmental policy
KW - Tuberculosis
KW - Saint Louis (Mo.)
KW - Missouri
KW - Homeless shelter
KW - Mycobacterium tuberculosis
KW - TB
KW - Ultraviolet germicidal irradiation
KW - Ventilation
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 37562325; Coffey, Christopher C. 1; Email Address: CCoffey@cdc.gov; Hudnall, Judith B. 1; Martin Jr., Stephen B. 1; Affiliations: 1: Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, USA; Issue Info: Apr2009, Vol. 18 Issue 2, p168; Thesaurus Term: Environmental engineering; Thesaurus Term: Environmental policy; Thesaurus Term: Tuberculosis; Subject: Saint Louis (Mo.); Subject: Missouri; Author-Supplied Keyword: Homeless shelter; Author-Supplied Keyword: Mycobacterium tuberculosis; Author-Supplied Keyword: TB; Author-Supplied Keyword: Ultraviolet germicidal irradiation; Author-Supplied Keyword: Ventilation ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 15p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1177/1420326X09103008
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kobayashi, Kenichi
AU - Miyagawa, Muneyuki
AU - Rui-Sheng Wang
AU - Suda, Megumi
AU - Sekiguchi, Soichiro
AU - Honma, Takeshi
T1 - Effects of in Utero Exposure to 2,2′,4,4′,5,5′-hexachlorobiphenyl on Postnatal Development and Thyroid Function in Rat Offspring.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/04//
VL - 47
IS - 2
M3 - Article
SP - 189
EP - 197
SN - 00198366
AB - The article presents a study that examines the effects of prenatal exposure to 2,2',4,4',5,5'-hexachlorobiphenyl or polychlorobiphenyl (PCB 153) on postnatal development and thyroid function in rat offspring. It states that pregnant rats were given PCB 153 in 0, 1, or 4 milligram per kilogram per day orally from gestational day (GD) from 10 to 16 days. Researchers examined the somatic parameters and thyroid functions of rats.
KW - RESEARCH
KW - Polychlorinated biphenyls
KW - Developmental biology
KW - Postnatal development in animals
KW - Rats
KW - Thyroid gland function tests
KW - 2
KW - 2′
KW - 4
KW - 4′
KW - 5
KW - 5′-hexachlorobiphenyl (PCB 153)
KW - Postnatal development
KW - Rat
KW - Thyroid
KW - Thyroid-stimulating hormone (TSH)
KW - Thyroxine (T4)
KW - Tri-iodothyronine (T3)
N1 - Accession Number: 43086770; Kobayashi, Kenichi 1; Miyagawa, Muneyuki 1; Rui-Sheng Wang 1; Suda, Megumi 1; Sekiguchi, Soichiro 1; Honma, Takeshi 1; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, Kawasaki 214-8585, Japan; Issue Info: 2009, Vol. 47 Issue 2, p189; Thesaurus Term: RESEARCH; Thesaurus Term: Polychlorinated biphenyls; Thesaurus Term: Developmental biology; Thesaurus Term: Postnatal development in animals; Subject Term: Rats; Subject Term: Thyroid gland function tests; Author-Supplied Keyword: 2; Author-Supplied Keyword: 2′; Author-Supplied Keyword: 4; Author-Supplied Keyword: 4′; Author-Supplied Keyword: 5; Author-Supplied Keyword: 5′-hexachlorobiphenyl (PCB 153); Author-Supplied Keyword: Postnatal development; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Thyroid; Author-Supplied Keyword: Thyroid-stimulating hormone (TSH); Author-Supplied Keyword: Thyroxine (T4); Author-Supplied Keyword: Tri-iodothyronine (T3); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schatzel, Steven J.
T1 - Identifying sources of respirable quartz and silica dust in underground coal mines in southern West Virginia, western Virginia, and eastern Kentucky
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2009/04//
VL - 78
IS - 2
M3 - Article
SP - 110
EP - 118
SN - 01665162
AB - Abstract: Prior research has suggested that the source of respirable silica dust in underground coal mines is typically the immediate top or bottom lithology adjacent to the mined seam, not mineral matter bound within the mined coal bed. Geochemical analyses were applied in an effort to identify the specific source rock of respirable quartz dust in coal mines. The analyses also demonstrate the compositional changes that take place in the generation of the respirable dust fraction from parent rock material. All six mine sites were mining coal with relatively low mineral matter content, although two mines were operating in the Fire Clay coal bed which contains a persistent tonstein. Interpretations of Ca, Mg, Mn, Na, and K concentrations strongly suggest that the top strata above the mined seam is the primary source of mineral dust produced during mining. One site indicates a mixed or bottom source, possibly due to site specific conditions. Respirable dust compositional analyses suggest a direct relationship between the quantity of mineral Si and the quantity of quartz Si. A similar relationship was not found in either the top or bottom rocks adjacent to the mined seam. An apparent loss of elemental Al was noted in the respirable dust fraction when compared to potential parent rock sources. Elemental Al is present in top and bottom rock strata within illite, kaolinite, feldspar, and chlorite. A possible explanation for loss of Al in the respirable dust samples is the removal of clays and possibly chlorite minerals. It is expected that removal of this portion of the Al bearing mineral matter occurs during rock abrasion and dust transport prior to dust capture on the samplers. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - SILICON compounds
KW - COAL industry
KW - KENTUCKY
KW - Analysis
KW - Coal geochemistry
KW - Coal mining
KW - Quartz
KW - Respirable dust
KW - Silicosis
N1 - Accession Number: 36969339; Schatzel, Steven J. 1; Email Address: zia6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA 15236, USA; Source Info: Apr2009, Vol. 78 Issue 2, p110; Subject Term: COAL mines & mining; Subject Term: SILICON compounds; Subject Term: COAL industry; Subject Term: KENTUCKY; Author-Supplied Keyword: Analysis; Author-Supplied Keyword: Coal geochemistry; Author-Supplied Keyword: Coal mining; Author-Supplied Keyword: Quartz; Author-Supplied Keyword: Respirable dust; Author-Supplied Keyword: Silicosis; NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 454319 Other fuel dealers; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 324199 All Other Petroleum and Coal Products Manufacturing; NAICS/Industry Codes: 454310 Fuel Dealers; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.coal.2009.01.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kopecko, Dennis J.
AU - Sieber, Heike
AU - Ures, Jose A.
AU - Fürer, Andreas
AU - Schlup, Jacqueline
AU - Knof, Ulrich
AU - Collioud, Andre
AU - Xu, DeQi
AU - Colburn, Kevin
AU - Dietrich, Guido
T1 - Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
Y1 - 2009/04//
VL - 299
IS - 4
M3 - Article
SP - 233
EP - 246
SN - 14384221
AB - Abstract: The attenuated live bacterial vaccine strain Salmonella enterica Serovar Typhi Ty21a is the main constituent of Vivotif, the only licensed oral vaccine against typhoid fever. The strain was developed in the 1970s by chemical mutagenesis. In the course of this mutagenesis, a number of mutations were introduced into the vaccine strain. Characterisation of the vaccine strain during development as well as release of master- and working seed lots (MSL and WSL) and commercial batches is based on phenotypic assays assessing microbiological and biochemical characteristics of Ty21a. In the current study, we have analysed by DNA sequencing the specific mutations originally correlated with the attenuation of strain Ty21a. These data demonstrate the stability of these mutations for MSLs and WSLs of Ty21a produced between 1980 and 2005. Finally, we have confirmed the correlation of these genetic mutations with the expected phenotypic attenuations for the seed lots used in vaccine manufacture over 25 years. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Medical Microbiology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Mutation (Biology)
KW - Biological assay
KW - Bacterial vaccines
KW - Salmonella typhi
KW - Mutagenesis
KW - Typhoid fever
KW - Oral vaccines
KW - Nucleotide sequence
KW - Genetic and phenotypic analyses
KW - Typhoid fever vaccine
KW - Vaccine strain Ty21a
N1 - Accession Number: 37578363; Kopecko, Dennis J. 1; Sieber, Heike 2; Ures, Jose A. 2; Fürer, Andreas 2; Schlup, Jacqueline 2; Knof, Ulrich 2; Collioud, Andre 2; Xu, DeQi 1; Colburn, Kevin 1; Dietrich, Guido 2; Email Address: guido.h.dietrich@gskbio.com; Affiliations: 1: Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, HFM440, Bethesda, MD 20892, USA; 2: Berna Biotech AG, Rehhagstr. 79, CH-3018 Berne, Switzerland; Issue Info: Apr2009, Vol. 299 Issue 4, p233; Thesaurus Term: VACCINATION; Thesaurus Term: Mutation (Biology); Thesaurus Term: Biological assay; Subject Term: Bacterial vaccines; Subject Term: Salmonella typhi; Subject Term: Mutagenesis; Subject Term: Typhoid fever; Subject Term: Oral vaccines; Subject Term: Nucleotide sequence; Author-Supplied Keyword: Genetic and phenotypic analyses; Author-Supplied Keyword: Typhoid fever vaccine; Author-Supplied Keyword: Vaccine strain Ty21a; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.ijmm.2008.09.003
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ruder, A. M.
AU - Butler, M. A.
AU - Sanderson, W. T.
AU - Carreón, T.
AU - Waters, M. A.
AU - Zivkovich, Z. E.
T1 - The NIOSH Retrospective Pesticide Reference Database.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2009/04//
VL - 15
IS - 2
M3 - Article
SP - 143
EP - 156
SN - 10747583
AB - The article offers a study which aims to classify pesticide reactions in biologically relevant categories in the U.S. It noted on the National Institute for Occupational Safety and Health (NIOSH) Retrospective Pesticide Reference Database (NIOHS-RPRD) built over 1000 pesticide products and chemicals using multiple sources. It is stated that the significance of the database was evaluated by comparing numbers of reactions naming actual chemicals to total responses connected to those chemicals. It cited that the NIOSH-RPRD has been an important tool among researchers to evaluate, group, and correct pesticide responses.
KW - Pesticides
KW - Agricultural pests -- Control
KW - Agricultural chemicals
KW - Pests -- Control
KW - Pesticide resistance
KW - Systemic agricultural chemicals
KW - Research
KW - United States
KW - Agricultural workers
KW - Agriculture
KW - Agrochemicals
KW - Pesticides Classification
KW - Research design
KW - Risk assessment
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 39665633; Ruder, A. M. 1; Email Address: amr2@cdc.gov; Butler, M. A. 2; Sanderson, W. T. 3; Carreón, T. 4,5; Waters, M. A. 6; Zivkovich, Z. E. 7; Affiliations: 1: Research Epidemiologist, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio; 2: Research Toxicologist, NIOSH Division of Applied Research and Technology, Cincinnati, Ohio; 3: Associate Professor, Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa; 4: Senior Service Fellow, NIOSH Division of Surveillance, Hazard Evaluations and Field Studies, University of Cincinnati, Cincinnati, Ohio; 5: Adjunct Assistant Professor, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio; 6: Research Health Scientist, NIOSH Division of Applied Research and Technology, Cincinnati, Ohio; 7: Business Analyst Consultant, Dell Corporation, Austin, Texas; Issue Info: Apr2009, Vol. 15 Issue 2, p143; Thesaurus Term: Pesticides; Thesaurus Term: Agricultural pests -- Control; Thesaurus Term: Agricultural chemicals; Thesaurus Term: Pests -- Control; Thesaurus Term: Pesticide resistance; Thesaurus Term: Systemic agricultural chemicals; Thesaurus Term: Research; Subject: United States; Author-Supplied Keyword: Agricultural workers; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: Agrochemicals; Author-Supplied Keyword: Pesticides Classification; Author-Supplied Keyword: Research design; Author-Supplied Keyword: Risk assessment ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 926140 Regulation of Agricultural Marketing and Commodities; NAICS/Industry Codes: 561710 Exterminating and Pest Control Services; Number of Pages: 14p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Myers, M. L.
AU - Westneat, S. C.
AU - Myers, J. R.
AU - Cole, H. P.
T1 - Prevalence of ROPS-Equipped Tractors in U.S. Aquaculture.
JO - Journal of Agricultural Safety & Health
JF - Journal of Agricultural Safety & Health
Y1 - 2009/04//
VL - 15
IS - 2
M3 - Article
SP - 185
EP - 194
SN - 10747583
AB - The article offers a study which analysis and depicts the prevalence of rollover protective structure (ROPS) equipped tractors on farms involved in aquaculture in the U.S. According to the article, the analysis concluded that 78% of tractors utilized in aquaculture were equipped with ROPS in contrast to the prevalence of ROPS at 49% for all of agriculture. It is stated that although the national sample for aquaculture included only 75 farms and 137 tractors, several hypotheses can be obtained as an outcome of the study.
KW - Aquaculture
KW - Agriculture
KW - Agricultural equipment
KW - Farm management
KW - Fish culture
KW - Farms
KW - Rollover protective structures (Machinery)
KW - Farm tractors
KW - United States
KW - Fish farming
KW - Rollover protective structures
KW - ROPS
KW - Tractors
N1 - Accession Number: 39665636; Myers, M. L. 1; Email Address: melvinmyers@charter.net; Westneat, S. C. 2; Myers, J. R. 3; Cole, H. P. 4; Affiliations: 1: Associate Professor, University of Kentucky College of Public Health, Southeast Center for Agricultural Health and Injury Prevention, Flowery Branch, Georgia; 2: Data Analyst, College of Nursing, University of Kentucky, Lexington, Kentucky; 3: Health Statistician, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 4: Professor, College of Public Health, Southeast Center for Agricultural Health and Injury Prevention, University of Kentucky, Lexington, Kentucky; Issue Info: Apr2009, Vol. 15 Issue 2, p185; Thesaurus Term: Aquaculture; Thesaurus Term: Agriculture; Thesaurus Term: Agricultural equipment; Thesaurus Term: Farm management; Thesaurus Term: Fish culture; Thesaurus Term: Farms; Subject Term: Rollover protective structures (Machinery); Subject Term: Farm tractors; Subject: United States; Author-Supplied Keyword: Fish farming; Author-Supplied Keyword: Rollover protective structures; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: Tractors; NAICS/Industry Codes: 423820 Farm and Garden Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 333111 Farm Machinery and Equipment Manufacturing; NAICS/Industry Codes: 238299 All other building equipment contractors; NAICS/Industry Codes: 417110 Farm, lawn and garden machinery and equipment merchant wholesalers; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 115116 Farm Management Services; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 333110 Agricultural implement manufacturing; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 10p; Illustrations: 1 Black and White Photograph, 6 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Scherr, Daniel
AU - Dalal, Darshan
AU - Chilukuri, Karuna
AU - Dong, Jun
AU - Spragg, David
AU - Henrikson, Charles A.
AU - Nazarian, Saman
AU - Cheng, Alan
AU - Berger, Ronald D.
AU - Abraham, Theodore P.
AU - Calkins, Hugh
AU - Marine, Joseph E.
T1 - Incidence and Predictors of Left Atrial Thrombus Prior to Catheter Ablation of Atrial Fibrillation.
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
Y1 - 2009/04//
VL - 20
IS - 4
M3 - Article
SP - 379
EP - 384
PB - Wiley-Blackwell
SN - 10453873
AB - Background: Transesophageal echocardiography (TEE) is commonly used prior to catheter ablation of atrial fibrillation (AF) in order to exclude left atrial (LA) thrombus. However, the incidence and predictors of LA thrombus detected with TEE have not been systematically examined in this setting. Methods: This study included 732 cases (mean age 57 ± 11 years; 23% female; 353 persistent AF) in 585 consecutive patients referred for catheter ablation of AF. Patients were anticoagulated for at least 4 weeks prior to the procedure and then bridged with enoxaparin. TEE was performed in all cases within 24 hours prior to ablation. Results: Preprocedural TEE revealed LA thrombus in 12 of 732 cases (1.6%), all located in the LA appendage. Among these 12 patients, 9 had persistent AF and 3 had paroxysmal AF. All patients with thrombus had an LA size ≥ 4.5 cm. LA thrombus was present in 0.3%, 1.4%, and 5.3% of patients with CHADS2 scores of 0, 1, and ≥ 2, respectively. In multivariate analysis, a CHADS2 score ≥ 2 and larger LA diameter remained significant predictors of LA thrombus. Conclusions: Despite oral anticoagulation treatment, there is a small but significant incidence of LA thrombus by TEE prior to AF ablation. A CHADS2 score ≥ 2 and larger LA diameter are independent predictors of LA thrombus in this patient population, while type of AF or rhythm at the time of TEE is not. The risk of LA thrombus is low in patients with a CHADS2 score of 0 and in patients with an LA diameter < 4.5 cm. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cardiovascular Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSESOPHAGEAL echocardiography
KW - CATHETER ablation
KW - ATRIAL fibrillation
KW - MULTIVARIATE analysis
KW - ECHOCARDIOGRAPHY
KW - ablation
KW - atrial fibrillation
KW - complication
KW - echocardiography
KW - thrombus
N1 - Accession Number: 37137955; Scherr, Daniel 1,2 Dalal, Darshan 1 Chilukuri, Karuna 1 Dong, Jun 1,3 Spragg, David 1 Henrikson, Charles A. 1 Nazarian, Saman 1 Cheng, Alan 1 Berger, Ronald D. 1 Abraham, Theodore P. 1 Calkins, Hugh 1 Marine, Joseph E. 1; Email Address: jmarine2@jhmi.edu; Affiliation: 1: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA 2: Division of Cardiology, Department of Medicine, Medical University of Graz, Austria 3: Division of Cardiovascular Devices, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, USA; Source Info: Apr2009, Vol. 20 Issue 4, p379; Subject Term: TRANSESOPHAGEAL echocardiography; Subject Term: CATHETER ablation; Subject Term: ATRIAL fibrillation; Subject Term: MULTIVARIATE analysis; Subject Term: ECHOCARDIOGRAPHY; Author-Supplied Keyword: ablation; Author-Supplied Keyword: atrial fibrillation; Author-Supplied Keyword: complication; Author-Supplied Keyword: echocardiography; Author-Supplied Keyword: thrombus; Number of Pages: 6p; Illustrations: 1 Black and White Photograph, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1540-8167.2008.01336.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105470503
T1 - Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups.
AU - Kang TS
AU - Woo SW
AU - Park HJ
AU - Lee Y
AU - Roh J
Y1 - 2009/04//
N1 - Accession Number: 105470503. Language: English. Entry Date: 20090605. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Korea Food and Drug Administration (07151KFDA675). NLM UID: 8704308.
KW - Ethanol -- Metabolism
KW - Alcoholism -- Familial and Genetic
KW - Polymorphism, Genetic
KW - Chi Square Test
KW - Descriptive Statistics
KW - Funding Source
KW - Genes
KW - Genotype
KW - Koreans
KW - Polymerase Chain Reaction
KW - Human
SP - 225
EP - 230
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
JA - J CLIN PHARM THER
VL - 34
IS - 2
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND AND OBJECTIVES: Recent studies of the genetics of alcoholism have considered genetic factors in alcohol metabolism and have identified functional polymorphisms in genes encoding enzymes involved in ethanol metabolism. The aim of this study was to estimate the genotype and allele frequencies of polymorphisms of three major ethanol-metabolizing enzymes (ADH2, ALDH2 and CYP2E1) in Koreans and to compare them with those of other ethnic groups. METHODS: We chose three polymorphisms, ADH2 (*2), ALDH2 (*2) and CYP2E1 (c2), which are most likely to affect alcohol metabolism. To evaluate the allele frequencies of these single-nucleotide polymorphisms, 342 healthy Korean volunteers were recruited. Each genotype was determined by the TaqMan or SNaPshot method with genomic DNA extracted from peripheral leucocytes. We compared these allele frequencies with those of other ethnic groups registered on the International HapMap database. RESULTS AND DISCUSSION: The allele frequencies in Koreans were 80.3% for the ADH2 (*2), 13.9% for ALDH2 (*2), and 20.9% for CYP2E1 (c2). Other Asians, including Japanese and Chinese populations, show similar frequencies (Japanese, 73.9%, 22.7%, and 20.5% respectively and Chinese, 76.7%, 15.6%, and 28.9% respectively), whereas African and European groups have quite different frequencies (Europeans, 0%, 0%, and 5.1% respectively and African, 0%, 0%, and 0% respectively). CONCLUSION: Our current observations provide data on the prevalence of polymorphisms of ethanol-metabolizing enzymes, which should be useful in assessing the comparative susceptibility of different populations to diseases related to ethanol consumption.
SN - 0269-4727
AD - Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea
U2 - PMID: 19250143.
DO - 10.1111/j.1365-2710.2008.00986.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Reuter, Gábor
AU - Fodor, Domonka
AU - Forgách, Petra
AU - Kátai, Andrea
AU - Szűcs, György
T1 - Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2009/04//
VL - 44
IS - 4
M3 - Article
SP - 277
EP - 281
SN - 13866532
AB - Abstract: Background: Hepatitis E virus (HEV) is a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raising the possibility that HEV infection is also a zoonosis. Objectives/study design: Molecular detection and epidemiology of HEV in humans (South-East Hungary) with acute hepatitis and in domestic (pig, cattle) and wild (boar and roe-deer) animals (countrywide) by ELISA and RT-PCR. Results: Between 2001 and 2006, a total of 116 (9.6%) of 1203 human sera were positive by HEV IgM ELISA and 13 (24.5%) of 53 samples were also confirmed by RT-PCR and sequencing. Forty-two (27.3%) of 154, 11 (34.4%) of 32 and 9 (12.2%) of 74 samples were RT-PCR-positive from swine (feces: 22.7%; liver: 30.8%), roe-deer (liver) and wild boar (liver), respectively. Except for an imported infection caused by genotype 1, 19 sequences (human: 12, swine: 4, roe-deer: 1, wild boar: 2) belong to genotype 3 HEV. Genetically identical strains were detected in human and roe-deer and in 2 other human clusters. Conclusions: HEV is an endemic agent in Hungary. Consumption of raw or undercooked meat-products is one of the possible sources of the indigenous HEV infections. Cross-species infection with genotype 3 HEV potentially involves a food-borne transmission route in Hungary. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ZOONOSES
KW - HEPATITIS viruses
KW - HEPATITIS E
KW - COMMUNICABLE diseases -- Transmission
KW - SWINE as laboratory animals
KW - DEVELOPING countries
KW - HUNGARY
KW - Endemic
KW - Food-borne
KW - Hepatitis E virus
KW - Zoonosis
N1 - Accession Number: 37232650; Reuter, Gábor 1; Email Address: reuter.gabor@baranya.antsz.hu Fodor, Domonka 2 Forgách, Petra 3 Kátai, Andrea 4 Szűcs, György 1; Affiliation: 1: Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, H-7623 Szabadság út 7, Pécs, Hungary 2: Department of Infectology, City Hospital Szeged, Csongrád County, Szeged, Hungary 3: Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Budapest, Hungary 4: Regional Laboratory of Virology, ÁNTSZ Csongrád County Institute of State Public Health Service, Szeged, Hungary; Source Info: Apr2009, Vol. 44 Issue 4, p277; Subject Term: ZOONOSES; Subject Term: HEPATITIS viruses; Subject Term: HEPATITIS E; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: SWINE as laboratory animals; Subject Term: DEVELOPING countries; Subject Term: HUNGARY; Author-Supplied Keyword: Endemic; Author-Supplied Keyword: Food-borne; Author-Supplied Keyword: Hepatitis E virus; Author-Supplied Keyword: Zoonosis; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jcv.2009.01.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37232650&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Uhlenhaut, Christine
AU - Cohen, Jeffrey I.
AU - Fedorko, Daniel
AU - Nanda, Santosh
AU - Krause, Philip R.
T1 - Use of a universal virus detection assay to identify human metapneumovirus in a hematopoietic stem cell transplant recipient with pneumonia of unknown origin
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2009/04//
VL - 44
IS - 4
M3 - Article
SP - 337
EP - 339
SN - 13866532
AB - Abstract: Background: Development of uncommon viral infections in immunocompromised transplant recipients can pose major diagnostic challenges. We present a case report of an immunocompromised patient suffering from pneumonia, for which the causative agent was not identified by routine methods. Objectives: To identify the potential cause of the pneumonia using a degenerate oligonucleotide primer (DOP)-PCR assay that is designed to detect all viruses. Study design: DOP-PCR was applied to bronchoalveolar lavage fluid from this patient. Generic PCR products were cloned and sequenced. Results: The novel universal virus assay detected human metapneumovirus in the clinical sample. The finding was confirmed by two independent metapneumovirus specific PCRs targeting different regions of the viral genome. Conclusions: The DOP-PCR was used to detect and identify the sequence of an unidentified virus. This study provides proof of concept for the use of clinically relevant specimens in this unbiased universal assay, which requires no previous viral sequence information. [Copyright &y& Elsevier]
AB - Copyright of Journal of Clinical Virology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIOLOGICAL assay
KW - RNA viruses
KW - STEM cell transplantation
KW - TRANSPLANTATION of organs, tissues, etc.
KW - PNEUMONIA
KW - PATIENTS
KW - VIRUS diseases -- Diagnosis
KW - POLYMERASE chain reaction
KW - bronchoalveolar lavage ( BAL )
KW - degenerate oligonucleotide primer PCR ( DOP-PCR )
KW - hematopoietic stem cell transplant ( HSCT )
KW - Immunocompromised host
KW - Virus detection
KW - Virus discovery
KW - Virus disease diagnosis
KW - Virus disease etiology
N1 - Accession Number: 37232663; Uhlenhaut, Christine 1 Cohen, Jeffrey I. 2 Fedorko, Daniel 3 Nanda, Santosh 1 Krause, Philip R. 1; Email Address: philip.krause@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Center for Biologics, Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892-4555, USA 2: Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1888, USA 3: Microbiology Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Apr2009, Vol. 44 Issue 4, p337; Subject Term: MICROBIOLOGICAL assay; Subject Term: RNA viruses; Subject Term: STEM cell transplantation; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: PNEUMONIA; Subject Term: PATIENTS; Subject Term: VIRUS diseases -- Diagnosis; Subject Term: POLYMERASE chain reaction; Author-Supplied Keyword: bronchoalveolar lavage ( BAL ); Author-Supplied Keyword: degenerate oligonucleotide primer PCR ( DOP-PCR ); Author-Supplied Keyword: hematopoietic stem cell transplant ( HSCT ); Author-Supplied Keyword: Immunocompromised host; Author-Supplied Keyword: Virus detection; Author-Supplied Keyword: Virus discovery; Author-Supplied Keyword: Virus disease diagnosis; Author-Supplied Keyword: Virus disease etiology; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.jcv.2009.01.011
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Jakab, F.
AU - Varga, L.
AU - Nyul, Z.
AU - Walter, J.
AU - Berke, T.
AU - Mitchell, D.K.
AU - Matson, D.O.
AU - Szűcs, G.
T1 - Acute viral gastroenteritis among hospitalized children between 2003 and 2005 in Baranya County, Hungary
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
Y1 - 2009/04//
VL - 44
IS - 4
M3 - Letter
SP - 340
EP - 341
SN - 13866532
N1 - Accession Number: 37232664; Jakab, F. 1,2; Email Address: jakabf@gamma.ttk.pte.hu Varga, L. 3 Nyul, Z. 3 Walter, J. 3 Berke, T. 4 Mitchell, D.K. 4 Matson, D.O. 4 Szűcs, G. 2; Affiliation: 1: University of Pécs, Institute of Biology, Pécs, Hungary 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary 3: “Kerpel-Frónius Ödön” Children's Hospital, Pécs, Hungary 4: Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, VA, USA; Source Info: Apr2009, Vol. 44 Issue 4, p340; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.jcv.2009.01.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BENFENATI, E.
AU - BENIGNI, R.
AU - DEMARINI, D.M.
AU - HELMA, C.
AU - KIRKLAND, D.
AU - MARTIN, T.M.
AU - MAZZATORTA, P.
AU - OUEDRAOGO-ARRAS, G.
AU - RICHARD, A.M.
AU - SCHILTER, B.
AU - SCHOONEN, W.G. E. J.
AU - SNYDER, R.D.
AU - YANG, C.
T1 - Predictive Models for Carcinogenicity and Mutagenicity: Frameworks, State-of-the-Art, and Perspectives.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2009/04//Apr-Jun2009
VL - 27
IS - 2
M3 - Article
SP - 57
EP - 90
SN - 10590501
AB - Mutagenicity and carcinogenicity are endpoints of major environmental and regulatory concern. These endpoints are also important targets for development of alternative methods for screening and prediction due to the large number of chemicals of potential concern and the tremendous cost (in time, money, animals) of rodent carcinogenicity bioassays. Both mutagenicity and carcinogenicity involve complex, cellular processes that are only partially understood. Advances in technologies and generation of new data will permit a much deeper understanding. In silico methods for predicting mutagenicity and rodent carcinogenicity based on chemical structural features, along with current mutagenicity and carcinogenicity data sets, have performed well for local prediction (i.e., within specific chemical classes), but are less successful for global prediction (i.e., for a broad range of chemicals). The predictivity of in silico methods can be improved by improving the quality of the data base and endpoints used for modelling. In particular, in vitro assays for clastogenicity need to be improved to reduce false positives (relative to rodent carcinogenicity) and to detect compounds that do not interact directly with DNA or have epigenetic activities. New assays emerging to complement or replace some of the standard assays include Vitotox™, GreenScreenGC, and RadarScreen. The needs of industry and regulators to assess thousands of compounds necessitate the development of high-throughput assays combined with innovative data-mining and in silico methods. Various initiatives in this regard have begun, including CAESAR, OSIRIS, CHEMOMENTUM, CHEMPREDICT, OpenTox, EPAA, and ToxCast™. In silico methods can be used for priority setting, mechanistic studies, and to estimate potency. Ultimately, such efforts should lead to improvements in application of in silico methods for predicting carcinogenicity to assist industry and regulators and to enhance protection of public health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Carcinogenicity
KW - Mutagenicity testing
KW - Biological assay
KW - Nucleic acids
KW - Genetic toxicology
KW - Carcinogenesis
KW - Prospecting
KW - Predictive tests
KW - Toxicological interactions
KW - in silico
KW - mutagenicity
KW - predictive methods
KW - QSAR
N1 - Accession Number: 38703707; BENFENATI, E. 1; Email Address: benfenati@marionegri.it; BENIGNI, R. 2; DEMARINI, D.M. 3; HELMA, C. 4; KIRKLAND, D. 5; MARTIN, T.M. 6; MAZZATORTA, P. 7; OUEDRAOGO-ARRAS, G. 8; RICHARD, A.M. 9; SCHILTER, B. 7; SCHOONEN, W.G. E. J. 10; SNYDER, R.D. 11; YANG, C. 12; Affiliations: 1: Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy; 2: Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy; 3: Environmental Carcinogenesis Division, US EPA, Research Triangle Park, North Carolina, USA; 4: In Silico Toxicology, Basel, Switzerland; 5: Covance Laboratories Ltd, Harrogate, United Kingdom; 6: Sustainable Technology Division, National Risk Management Research Laboratory, US EPA, Cincinnati, Ohio, USA; 7: Quality and Safety Department, Nestlé Research Center, Lausanne, Switzerland; 8: L'Oreél, Safety Research Department, Aulnay-sous-Bois, France; 9: National Center for Computational Toxicology, US EPA, Research Triangle Park, North Carolina, USA; 10: Schering-Plough Research Institute, Oss, The Netherlands; 11: Schering-Plough Research Institute, Summit, New Jersey, USA; 12: Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA; Issue Info: Apr-Jun2009, Vol. 27 Issue 2, p57; Thesaurus Term: Carcinogenicity; Thesaurus Term: Mutagenicity testing; Thesaurus Term: Biological assay; Thesaurus Term: Nucleic acids; Thesaurus Term: Genetic toxicology; Thesaurus Term: Carcinogenesis; Thesaurus Term: Prospecting; Subject Term: Predictive tests; Subject Term: Toxicological interactions; Author-Supplied Keyword: in silico; Author-Supplied Keyword: mutagenicity; Author-Supplied Keyword: predictive methods; Author-Supplied Keyword: QSAR; NAICS/Industry Codes: 213119 Other support activities for mining; Number of Pages: 34p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/10590500902885593
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - FU, PETER P.
AU - HSIU-MEI CHIANG
AU - QINGSU XIA
AU - TAO CHEN
AU - BAI HSIUN CHEN
AU - JUE-JIE YIN
AU - KUO-CHING WEN
AU - GE LIN
AU - HONGTAO YU
T1 - Quality Assurance and Safety of Herbal Dietary Supplements.
JO - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
JF - Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews
Y1 - 2009/04//Apr-Jun2009
VL - 27
IS - 2
M3 - Article
SP - 91
EP - 119
SN - 10590501
AB - Since the U.S. Congress passed the Dietary Supplement Health and Education Act (DSHEA) in 1994, use of herbal products has been growing rapidly worldwide. To ensure consumer health protection, the quality and safety of herbal plants, particularly those used for dietary supplement preparations, must be determined. To date, toxicological data on the identification of genotoxic and tumorigenic ingredients in many raw herbs and their mechanisms of action are lacking. Thus, identification of carcinogenic components in herbal plants is timely and important. In this review, the issues of quality control and safety evaluation of raw herbs and herbal dietary supplements are discussed. Two examples of tumorigenicity and mechanism of tumor induction are discussed: aristolochic acid and riddelliine, both of which have been detected in Chinese herbal plants. It is proposed that an organized effort with international participation on cancer risk assessment should be actively pursued so that the safety of commercial herbal plants and herbal dietary supplements can be ensured. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Science & Health, Part C -- Environmental Carcinogenesis & Ecotoxicology Reviews is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Dietary supplements
KW - Genetic toxicology
KW - Herbal medicine
KW - Quality assurance
KW - Toxicological interactions
KW - United States
KW - Chinese traditional herbs
KW - Herbal dietary supplements
KW - quality assurance
KW - toxicological effects
KW - United States. Congress
N1 - Accession Number: 38703706; FU, PETER P. 1; Email Address: peter.fu@fda.hhs.gov; HSIU-MEI CHIANG 2; QINGSU XIA 1; TAO CHEN 1; BAI HSIUN CHEN 3; JUE-JIE YIN 4; KUO-CHING WEN 2; GE LIN 5; HONGTAO YU 6; Affiliations: 1: National Center for Toxicological Research, Jefferson, Arkansas, USA; 2: Department of Cosmeceutics, China Medical University, Taichung, Taiwan; 3: College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 4: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA; 5: Department of Pharmacology, The Chinese University of Hong Kong, Hong Kong, SAR; 6: Department of Chemistry, Jackson State University, Jackson, Mississippi, USA; Issue Info: Apr-Jun2009, Vol. 27 Issue 2, p91; Thesaurus Term: Dietary supplements; Thesaurus Term: Genetic toxicology; Subject Term: Herbal medicine; Subject Term: Quality assurance; Subject Term: Toxicological interactions; Subject: United States; Author-Supplied Keyword: Chinese traditional herbs; Author-Supplied Keyword: Herbal dietary supplements; Author-Supplied Keyword: quality assurance; Author-Supplied Keyword: toxicological effects ; Company/Entity: United States. Congress; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 921120 Legislative Bodies; Number of Pages: 29p; Illustrations: 9 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1080/10590500902885676
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Verrill, Linda
AU - Choinière, Conrad J.
T1 - Are Food Allergen Advisory Statements Really Warnings? Variation in Consumer Preferences and Consumption Decisions.
JO - Journal of Food Products Marketing
JF - Journal of Food Products Marketing
Y1 - 2009/04//
VL - 15
IS - 2
M3 - Article
SP - 139
EP - 151
SN - 10454446
AB - The authors surveyed consumers for preferences on allergen advisory statements on food labels (N = 1,243). They also conducted an experiment to assess how consumers use advisory statements (N = 4,049) to make food consumption decisions. Results show that food allergic individuals, including caregivers to food allergic individuals, and a control group of nonallergic people preferred “Allergen Information: May Contain ...” over three other statements tested. The experiment revealed measurable differences among the statements in how they are used to make food consumption decisions. Statements rated as more believable and more helpful also received higher ratings on a “likelihood of eating/serving” measure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Products Marketing is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONSUMERS' preferences
KW - ALLERGENS
KW - FOOD labeling
KW - CONSUMER behavior
KW - CONSUMPTION (Economics)
KW - FOOD industry
KW - FOOD supply
KW - COST & standard of living
KW - PACKAGED foods
KW - advisory statement
KW - allergens
KW - consumer preferences
KW - Food allergy
KW - food label
N1 - Accession Number: 37155011; Verrill, Linda 1; Email Address: Linda.Verrill@fda.hhs.gov Choinière, Conrad J. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA; Source Info: 2009, Vol. 15 Issue 2, p139; Subject Term: CONSUMERS' preferences; Subject Term: ALLERGENS; Subject Term: FOOD labeling; Subject Term: CONSUMER behavior; Subject Term: CONSUMPTION (Economics); Subject Term: FOOD industry; Subject Term: FOOD supply; Subject Term: COST & standard of living; Subject Term: PACKAGED foods; Author-Supplied Keyword: advisory statement; Author-Supplied Keyword: allergens; Author-Supplied Keyword: consumer preferences; Author-Supplied Keyword: Food allergy; Author-Supplied Keyword: food label; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 424420 Packaged Frozen Food Merchant Wholesalers; Number of Pages: 13p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10454440802316800
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - COHEN, NICOLE J.
AU - DEEDS, JONATHAN R.
AU - WONG, EUGENE S.
AU - HANNER, ROBERT H.
AU - YANCY, HALLE F.
AU - WHITE, KEVIN D.
AU - THOMPSON, TREVONNE M.
AU - WAHL, MICHAEL
AU - PHAM, TU D.
AU - GUICHARD, FRANCES M.
AU - IN HUH
AU - AUSTIN, CONNIE
AU - DIZIKES, GEORGE
AU - GERBER, SUSAN I.
T1 - Public Health Response to Puffer Fish (Tetrodotoxin) Poisoning from Mislabeled Product.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/04//
VL - 72
IS - 4
M3 - Article
SP - 810
EP - 817
SN - 0362028X
AB - Tetrodotoxin is a neurotoxin that occurs in select species of the family Tetraodontidae (puffer fish). It causes paralysis and potentially death if ingested in sufficient quantities. In 2007, two individuals developed symptoms consistent with tetrodotoxin poisoning after ingesting home-cooked puffer fish purchased in Chicago. Both the Chicago retailer and the California supplier denied having sold or imported puffer fish but claimed the product was monkfish. However, genetic analysis and visual inspection determined that the ingested fish and others from the implicated lot retrieved from the supplier belonged to the family Tetraodontidae. Tetrodotoxin was detected at high levels in both remnants of the ingested meal and fish retrieved from the implicated lot. The investigation led to a voluntary recall of monkfish distributed by the supplier in three states and placement of the supplier on the U.S. Food and Drug Administration's Import Alert for species misbranding. This case of tetrodotoxin poisoning highlights the need for continued stringent regulation of puffer fish importation by the U.S. Food and Drug Administration, education of the public regarding the dangers of puffer fish consumption, and raising awareness among medical providers of the diagnosis and management of foodborne toxin ingestions and the need for reporting to public health agencies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food poisoning
KW - Puffers (Fish)
KW - TOXICOLOGY
KW - Food labeling
KW - Tetrodotoxin
KW - Poisonous fishes
KW - Public health -- United States
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 39762921; COHEN, NICOLE J. 1; DEEDS, JONATHAN R. 2; Email Address: jonathan.deeds@fda.hhs.gov; WONG, EUGENE S. 3; HANNER, ROBERT H. 3; YANCY, HALLE F. 4; WHITE, KEVIN D. 2; THOMPSON, TREVONNE M. 5; WAHL, MICHAEL 5; PHAM, TU D. 1; GUICHARD, FRANCES M. 1; IN HUH 6; AUSTIN, CONNIE 7; DIZIKES, GEORGE 8; GERBER, SUSAN I. 1; Affiliations: 1: Chicago Department of Public Health, Chicago, Illinois 60612, USA; 2: U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition, College Park, Maryland 20740, USA; 3: Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada N1G 2W1; 4: U.S. Food and Drug Administration Center for Veterinary Medicine, Laurel, Maryland 20855, USA; 5: Illinois Poison Center, Chicago, Illinois 60606, USA; 6: Swedish Covenant Hospital, Chicago, Illinois 60625, USA; 7: Illinois Department of Public Health, Springfield, Illinois 62761, USA; 8: Illinois Department of Public Health, Chicago, Illinois 60612, USA; Issue Info: Apr2009, Vol. 72 Issue 4, p810; Thesaurus Term: Food poisoning; Thesaurus Term: Puffers (Fish); Thesaurus Term: TOXICOLOGY; Thesaurus Term: Food labeling; Subject Term: Tetrodotoxin; Subject Term: Poisonous fishes; Subject Term: Public health -- United States; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 8p; Illustrations: 2 Black and White Photographs, 2 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CHO, CHUNG Y.
AU - KEENER, WILLIAM K.
AU - GARBER, ERIC A. E.
T1 - Application of Deadenylase Electrochemiluminescence Assay for Ricin to Foods in a Plate Format.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/04//
VL - 72
IS - 4
M3 - Article
SP - 903
EP - 906
SN - 0362028X
AB - A recently developed bead-based deadenylase electrochemiluminescence assay for ricin is simple and sensitive in its ability to detect ricin, based on the catalytic activity of the toxin subunit, ricin A chain. The assay was modified to work in a 96-well plate format and evaluated by using juice samples. The plate-based assay, unlike the bead-based assay, includes wash steps that enable the removal of food particles. These steps minimize matrix effects and improve the signal-to-noise ratios and limits of detection (LOD). The LOD values for ricin in apple juice, vegetable juice, and citrate buffer by using the bead-based assay were 0.4, 1, and 0.1 µg/ml, respectively. In contrast, the LOD values for ricin by using the plate-based assay were 0.04, 0.1, and 0.04 µg/ml in apple juice, vegetable juice, and citrate buffer, respectively. The plate-based assay displayed three- to 10-fold lower LOD values than did the bead-based assay. Signal-to-noise ratios for the plate-based assay were comparable to those for the bead-based assay for ricin in citrate buffer, but 2- to 4.5-fold higher when the plate-based assay was used for analysis of juice samples. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ricin
KW - Food
KW - Plant toxins
KW - Chemiluminescence assay
KW - Signal-to-noise ratio
KW - Apple juice
KW - Vegetable juices
KW - Citrates
N1 - Accession Number: 39762938; CHO, CHUNG Y. 1; Email Address: Chung.Cho@fda.hhs.gov; KEENER, WILLIAM K. 2; GARBER, ERIC A. E. 1; Affiliations: 1: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740; 2: Idaho National Laboratory, Idaho Falls, Idaho 83415, USA; Issue Info: Apr2009, Vol. 72 Issue 4, p903; Thesaurus Term: Ricin; Thesaurus Term: Food; Thesaurus Term: Plant toxins; Subject Term: Chemiluminescence assay; Subject Term: Signal-to-noise ratio; Subject Term: Apple juice; Subject Term: Vegetable juices; Subject Term: Citrates; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 413190 Other specialty-line food merchant wholesalers; NAICS/Industry Codes: 311421 Fruit and Vegetable Canning; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105488582
T1 - Importance of recommendations for gestational weight gain.
AU - Kelly CY
AU - Clancy CM
Y1 - 2009/04//Apr-Jun2009
N1 - Accession Number: 105488582. Language: English. Entry Date: 20090501. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Obstetric Care; Quality Assurance; Women's Health. NLM UID: 9200672.
KW - Weight Gain -- In Pregnancy
KW - Birth Weight
KW - Clinical Research
KW - Female
KW - Fetus
KW - Infant, Newborn
KW - Maternal-Child Health
KW - Pregnancy
SP - 96
EP - 99
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 24
IS - 2
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. carmen.kelly@ahrq.hhs.gov
U2 - PMID: 19287245.
DO - 10.1097/NCQ.0b013e318198bca3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105488582&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carpenter, John F.
AU - Randolph, Theodore W.
AU - Jiskoot, Wim
AU - Crommelin, Daan J. A.
AU - Middaugh, C. Russell
AU - Winter, Gerhard
AU - Ying-Xin Fan
AU - Kirshner, Susan
AU - Verthelyi, Daniela
AU - Kozlowski, Steven
AU - Clouse, Kathleen A.
AU - Swann, Patrick G.
AU - Rosenberg, Amy
AU - Cherney, Barry
T1 - Overlooking subvisible particles in therapeutic protein products: Gaps that may compromise product quality.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2009/04//
VL - 98
IS - 4
M3 - Article
SP - 1201
EP - 1205
SN - 00223549
AB - The article discusses various topics related to protein aggregates. It states the analytical methods and the impact protein immunogenicity. It also highlights the critical gaps in the analysis and control of subvisible particles. Technical issues related to counting protein particles were also described by the author.
KW - CLINICAL medicine
KW - PROTEIN binding
KW - PRIONS
KW - IMMUNOGENETICS
KW - DRUGS
N1 - Accession Number: 36783312; Carpenter, John F. 1; Email Address: john.carpenter@uchsc.edu Randolph, Theodore W. 2 Jiskoot, Wim 3 Crommelin, Daan J. A. 4 Middaugh, C. Russell 5 Winter, Gerhard 6 Ying-Xin Fan 7 Kirshner, Susan 7 Verthelyi, Daniela 7 Kozlowski, Steven 8 Clouse, Kathleen A. 9 Swann, Patrick G. 9 Rosenberg, Amy 7 Cherney, Barry 7; Affiliation: 1: Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology, Box 238, University of Colorado Health Sciences Center, Denver, Colorado 80262 2: Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, University of Colorado, Boulder, Colorado 80309 3: Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands 4: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands 5: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047 6: Department of Pharmacy, Ludwig Maximilians University, 81377 Munich, Germany 7: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857 8: Office of Biotechnology Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857 9: Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857; Source Info: Apr2009, Vol. 98 Issue 4, p1201; Subject Term: CLINICAL medicine; Subject Term: PROTEIN binding; Subject Term: PRIONS; Subject Term: IMMUNOGENETICS; Subject Term: DRUGS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/jps.21530
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36783312&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsong, Yi
AU - Kelly, Roswitha
AU - Shen, Meiyu
AU - Zhong, Jinglin
T1 - Discussion.
JO - Journal of Quality Technology
JF - Journal of Quality Technology
Y1 - 2009/04//
VL - 41
IS - 2
M3 - Article
SP - 142
EP - 144
SN - 00224065
AB - The article focuses on the studies conducted on the historical development of pharmaceutical quality and the past roles and future opportunities for statisticians. It says that recent researches in the stability data and shelf-life estimation provides an advancement of proving the quality of drugs. In 1992, Ruberg and colleagues questioned the efficiency of the poolability test. Yoshioka and colleagues suggested the shelf-life equivalence method in 1997 which Tsong and colleagues revised in 2003. It mentions that the three statistical concepts to quality assessment and control are the shift from accepting a null hypothesis, defining quality in terms of high and low proportions, and achieving quality control by understanding the link between finished product and influencing factor.
KW - PHARMACEUTICAL industry
KW - QUALITY of products
KW - STATISTICIANS
KW - QUALITY control
KW - PRODUCT liability
KW - DRUGS
KW - DRUGS -- Storage
N1 - Accession Number: 37236245; Tsong, Yi 1; Email Address: yi.tsong@fda.hhs.gov; Kelly, Roswitha 1; Email Address: Roswitha.KelIy@fda.hhs.gov; Shen, Meiyu 1; Email Address: meiyu.shen@fda.hhs.gov; Zhong, Jinglin 1; Email Address: jinglin.zhong@fda.hhs.gov; Affiliations: 1: Division of Biometrics VI, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Silver Spring, MD 20993; Issue Info: Apr2009, Vol. 41 Issue 2, p142; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: QUALITY of products; Thesaurus Term: STATISTICIANS; Thesaurus Term: QUALITY control; Thesaurus Term: PRODUCT liability; Subject Term: DRUGS; Subject Term: DRUGS -- Storage; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Prevent Deep Vein Thrombosis and Pulmonary Embolism with a Healthful Diet
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2009/04//
VL - 109
IS - 4
M3 - Editorial
SP - 592
EP - 592
SN - 00028223
N1 - Accession Number: 37230277; Galson, Steven K. 1; Affiliation: 1: US Department of Health and Human Services; Source Info: Apr2009, Vol. 109 Issue 4, p592; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2009.02.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37230277&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105505089
T1 - From the Surgeon General. Prevent deep vein thrombosis and pulmonary embolism with a healthful diet.
AU - Galson SK
Y1 - 2009/04//
N1 - Accession Number: 105505089. Language: English. Entry Date: 20090424. Revision Date: 20150819. Publication Type: Journal Article; editorial. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 7503061.
KW - Diet -- Standards
KW - Exercise Physiology
KW - Pulmonary Embolism -- Prevention and Control
KW - Venous Thrombosis -- Prevention and Control
KW - Medical Practice, Evidence-Based
KW - Risk Factors
SP - 592
EP - 592
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 109
IS - 4
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Department of Health and Human Services, Washington, D.C., USA.
U2 - PMID: 19328250.
DO - 10.1016/j.jada.2009.02.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105505089&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MULHERN, BARBARA
AU - LENTZ, T. J.
T1 - TALES FROM THE TRENCH.
JO - Landscape Management
JF - Landscape Management
Y1 - 2009/04//
VL - 48
IS - 4
M3 - Article
SP - 109
EP - 111
PB - North Coast Media, LLC
SN - 08941254
AB - The article discusses risks involved with landscape service work, examining and describing the dangers involved with trenching and excavation activities. Landscape contractors should ensure that training and safety precautions are in place to ensure that cave-ins do not occur. Other topics include inadequate means to egress from a trench.
KW - CONTRACTORS
KW - INDUSTRIAL safety
KW - CONTRACT labor
KW - EARTHWORK -- Safety measures
KW - LANDSCAPE contractors
KW - SAFETY
KW - RETAINING walls
N1 - Accession Number: 37709352; MULHERN, BARBARA; LENTZ, T. J. 1; Affiliations: 1: Lead health scientist, National Institute for Occupational Safety and Health; Issue Info: Apr2009, Vol. 48 Issue 4, p109; Thesaurus Term: CONTRACTORS; Thesaurus Term: INDUSTRIAL safety; Thesaurus Term: CONTRACT labor; Subject Term: EARTHWORK -- Safety measures; Subject Term: LANDSCAPE contractors; Subject Term: SAFETY; Subject Term: RETAINING walls; NAICS/Industry Codes: 238140 Masonry Contractors; NAICS/Industry Codes: 238110 Poured Concrete Foundation and Structure Contractors; NAICS/Industry Codes: 237990 Other Heavy and Civil Engineering Construction; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Kozlowski, Steven
AU - Behrman, Rachel
T1 - Biosimilars: considerations for an abbreviated pathway.
JO - Leukemia & Lymphoma
JF - Leukemia & Lymphoma
Y1 - 2009/04//
VL - 50
IS - 4
M3 - Article
SP - 527
EP - 528
PB - Taylor & Francis Ltd
SN - 10428194
AB - In this article the author discusses the benefits and high costs of biopharmaceuticals. It emphasizes that establishing an abbreviated pathway, in which manufacturer depends to some extent on existing data about a licensed compound, may help increase availability on the important class of pharmaceuticals. It explains the significance of a large number of manufacturing changes made by innovators of protein pharmaceuticals and their partners.
KW - BIOPHARMACEUTICS
KW - DRUG bioavailability
KW - COST
KW - LICENSED products
KW - THERAPEUTICS
KW - PHARMACEUTICAL industry
N1 - Accession Number: 37697077; Kozlowski, Steven 1; Email Address: steven.kozlowski@fda.hhs.gov Behrman, Rachel 1; Affiliation: 1: US Food and Drug Administration, Silver Spring, MD, USA; Source Info: Apr2009, Vol. 50 Issue 4, p527; Subject Term: BIOPHARMACEUTICS; Subject Term: DRUG bioavailability; Subject Term: COST; Subject Term: LICENSED products; Subject Term: THERAPEUTICS; Subject Term: PHARMACEUTICAL industry; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 533110 Lessors of Nonfinancial Intangible Assets (except Copyrighted Works); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 2p; Document Type: Article
L3 - 10.1080/10428190902853151
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37697077&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, C. N.
AU - Flowers, A. R.
AU - Young, V. C.
AU - Gonzalez-Escalona, N.
AU - DePaola, A.
AU - Noriea III, N. F.
AU - Grimes, D. J.
T1 - Genetic Relatedness Among tdh+ and trh+ Vibrio parahaemolyticus Cultured from Gulf of Mexico Oysters ( Crassostrea virginica) and Surrounding Water and Sediment.
JO - Microbial Ecology
JF - Microbial Ecology
Y1 - 2009/04//
VL - 57
IS - 3
M3 - Article
SP - 437
EP - 443
SN - 00953628
AB - Pathogenic Vibrio parahaemolyticus ( Vp) ( tdh+/ trh+) represent a small percentage of environmental Vp populations, and very little is known about this subpopulation. Repetitive extragenic palindromic PCR and multilocus sequence analysis revealed heterogeneity among 41 Vp containing thermostable direct hemolysin ( tdh) and tdh-related hemolysin ( trh) that were isolated from Mississippi coastal environments from October 2006 to April 2007. There was no source-specific sequestering in oysters, water, or sediment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Microbial Ecology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO parahaemolyticus
KW - OYSTERS
KW - GASTROENTERITIS
KW - FOOD consumption
KW - MARINE resources
KW - GENES
KW - SEDIMENTS (Geology)
N1 - Accession Number: 36925501; Johnson, C. N. 1 Flowers, A. R. 1 Young, V. C. 1 Gonzalez-Escalona, N. 2 DePaola, A. 3 Noriea III, N. F. 1 Grimes, D. J. 1; Email Address: jay.grimes@usm.edu; Affiliation: 1: Gulf Coast Research Laboratory, University of Southern Mississippi, 703 East Beach Drive, Ocean Springs, MS 39564, USA 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA 3: Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, AL, USA; Source Info: Apr2009, Vol. 57 Issue 3, p437; Subject Term: VIBRIO parahaemolyticus; Subject Term: OYSTERS; Subject Term: GASTROENTERITIS; Subject Term: FOOD consumption; Subject Term: MARINE resources; Subject Term: GENES; Subject Term: SEDIMENTS (Geology); NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114113 Salt water fishing; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 1 Map; Document Type: Article
L3 - 10.1007/s00248-008-9418-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36925501&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joseph, Ajay
AU - Lee, Taewon
AU - Moland, Carrie L.
AU - Branham, William S.
AU - Fuscoe, James C.
AU - Leakey, Julian E.A.
AU - Allaben, William T.
AU - Lewis, Sherry M.
AU - Ali, Akhtar A.
AU - Desai, Varsha G.
T1 - Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
JO - Mitochondrion
JF - Mitochondrion
Y1 - 2009/04//
VL - 9
IS - 2
M3 - Article
SP - 149
EP - 158
SN - 15677249
AB - Abstract: Usnic acid is a lichen metabolite used as a weight-loss dietary supplement due to its uncoupling action on mitochondria. However, its use has been associated with severe liver disorders in some individuals. Animal studies conducted thus far evaluated the effects of usnic acid on mitochondria primarily by measuring the rate of oxygen consumption and/or ATP generation. To obtain further insight into usnic acid-mediated effects on mitochondria, we examined the expression levels of 542 genes associated with mitochondrial structure and functions in liver of B6C3F1 female mice using a mitochondria-specific microarray. Beginning at 8weeks of age, mice received usnic acid at 0, 60, 180, and 600ppm in ground, irradiated 5LG6 diet for 14days. Microarray analysis showed a significant effect of usnic acid on the expression of several genes only at the highest dose of 600ppm. A prominent finding of the study was a significant induction of genes associated with complexes I through IV of the electron transport chain. Moreover, several genes involved in fatty acid oxidation, the Krebs cycle, apoptosis, and membrane transporters were over-expressed. Usnic acid is a lipophilic weak acid that can diffuse through mitochondrial membranes and cause a proton leak (uncoupling). The up-regulation of complexes I–IV may be a compensatory mechanism to maintain the proton gradient across the mitochondrial inner membrane. In addition, induction of fatty acid oxidation and the Krebs cycle may be an adaptive response to uncoupling of mitochondria. [Copyright &y& Elsevier]
AB - Copyright of Mitochondrion is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METABOLITES
KW - MITOCHONDRIA
KW - OLIGONUCLEOTIDES
KW - DNA microarrays
KW - MICE as laboratory animals
KW - LIVER diseases
KW - WEIGHT loss
KW - DIETARY supplements
KW - 3-hydroxyisobutyrate dehydrogenase ( Hibadh )
KW - adenosine diphosphate ( ADP )
KW - adenosine triphosphate ( ATP )
KW - anionic form of usnic acid (usniate anion) ( UA− )
KW - carnitine palmitoyltransferase 1 ( CPT1 )
KW - citrate synthase ( Cs )
KW - coenzyme A ( CoA )
KW - electron transport chain ( ETC )
KW - Female B6C3F1 mice
KW - flavin adenine dinucleotide (oxidized form) ( FAD )
KW - flavin adenine dinucleotide (reduced form) ( FADH2 )
KW - Gene expression
KW - inner mitochondrial membrane ( IMM )
KW - inorganic phosphorus ( Pi )
KW - inter-membrane space ( IMS )
KW - Liver
KW - malate dehydrogenase ( Mdh )
KW - mitochondrial DNA ( mtDNA )
KW - Mitochondrial functions
KW - nicotinamide adenine nucleotide (oxidized form) ( NAD+ )
KW - nicotinamide adenine nucleotide (reduced form) ( NADH )
KW - outer mitochondrial membrane ( OMM )
KW - oxygen ( O2 )
KW - proton ( H+ )
KW - transfer RNA ( tRNA )
KW - Usnic acid
KW - usnic acid ( UA )
N1 - Accession Number: 37159834; Joseph, Ajay 1 Lee, Taewon 2 Moland, Carrie L. 3 Branham, William S. 3 Fuscoe, James C. 3 Leakey, Julian E.A. 4 Allaben, William T. 4 Lewis, Sherry M. 4 Ali, Akhtar A. 4 Desai, Varsha G. 3; Email Address: varsha.desai@fda.hhs.gov; Affiliation: 1: University of Abertay Dundee, DD1 1HG Dundee, UK 2: Korea University, Department of Information and Mathematics, Jochiwon, Chungnam 339-700, Republic of Korea 3: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA 4: Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Apr2009, Vol. 9 Issue 2, p149; Subject Term: METABOLITES; Subject Term: MITOCHONDRIA; Subject Term: OLIGONUCLEOTIDES; Subject Term: DNA microarrays; Subject Term: MICE as laboratory animals; Subject Term: LIVER diseases; Subject Term: WEIGHT loss; Subject Term: DIETARY supplements; Author-Supplied Keyword: 3-hydroxyisobutyrate dehydrogenase ( Hibadh ); Author-Supplied Keyword: adenosine diphosphate ( ADP ); Author-Supplied Keyword: adenosine triphosphate ( ATP ); Author-Supplied Keyword: anionic form of usnic acid (usniate anion) ( UA− ); Author-Supplied Keyword: carnitine palmitoyltransferase 1 ( CPT1 ); Author-Supplied Keyword: citrate synthase ( Cs ); Author-Supplied Keyword: coenzyme A ( CoA ); Author-Supplied Keyword: electron transport chain ( ETC ); Author-Supplied Keyword: Female B6C3F1 mice; Author-Supplied Keyword: flavin adenine dinucleotide (oxidized form) ( FAD ); Author-Supplied Keyword: flavin adenine dinucleotide (reduced form) ( FADH2 ); Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: inner mitochondrial membrane ( IMM ); Author-Supplied Keyword: inorganic phosphorus ( Pi ); Author-Supplied Keyword: inter-membrane space ( IMS ); Author-Supplied Keyword: Liver; Author-Supplied Keyword: malate dehydrogenase ( Mdh ); Author-Supplied Keyword: mitochondrial DNA ( mtDNA ); Author-Supplied Keyword: Mitochondrial functions; Author-Supplied Keyword: nicotinamide adenine nucleotide (oxidized form) ( NAD+ ); Author-Supplied Keyword: nicotinamide adenine nucleotide (reduced form) ( NADH ); Author-Supplied Keyword: outer mitochondrial membrane ( OMM ); Author-Supplied Keyword: oxygen ( O2 ); Author-Supplied Keyword: proton ( H+ ); Author-Supplied Keyword: transfer RNA ( tRNA ); Author-Supplied Keyword: Usnic acid; Author-Supplied Keyword: usnic acid ( UA ); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.mito.2009.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37159834&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Murashov, Vladimir
AU - Howard, John
T1 - International standards for risk management in nanotechnology.
JO - Nature Nanotechnology
JF - Nature Nanotechnology
Y1 - 2009/04//
VL - 4
IS - 4
M3 - Letter
SP - 205
EP - 206
SN - 17483387
AB - A response by Vladimir Murashov and John Howard to a letter to the editor about their article "The U.S. Must Help Set International Standards for Nanotechnology" in a 2008 issue is presented.
KW - LETTERS to the editor
KW - NANOTECHNOLOGY
N1 - Accession Number: 37347323; Murashov, Vladimir 1; Email Address: vladimir.murashov@cdc.hhs.gov Howard, John 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Washington DC 20201, USA; Source Info: Apr2009, Vol. 4 Issue 4, p205; Subject Term: LETTERS to the editor; Subject Term: NANOTECHNOLOGY; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 2p; Document Type: Letter
L3 - 10.1038/nnano.2009.108
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37347323&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bayfield, Mark A.
AU - Maraia, Richard J.
T1 - Precursor-product discrimination by La protein during tRNA metabolism.
JO - Nature Structural & Molecular Biology
JF - Nature Structural & Molecular Biology
Y1 - 2009/04//
VL - 16
IS - 4
M3 - Article
SP - 430
EP - 437
PB - Nature Publishing Group
SN - 15459993
AB - La proteins bind pre-tRNAs at their UUU-3′OH ends, facilitating their maturation. Although the mechanism by which La binds pre-tRNA 3′ trailers is known, the function of the RNA binding β-sheet surface of the RNA-recognition motif (RRM1) is unknown. How La dissociates from UUU-3′OH–containing trailers after 3′ processing is also unknown. Here we show that La preferentially binds pre-tRNAs over processed tRNAs or 3′ trailer products through coupled use of two sites: one on the La motif and another on the RRM1 β-surface that binds elsewhere on tRNA. Two sites provide stable pre-tRNA binding, whereas the processed tRNA and 3′ trailer are released from their single sites relatively fast. RRM1 loop-3 mutations decrease affinity for pre-tRNA and tRNA, but not for the UUU-3′OH trailer, and impair tRNA maturation in vivo. We propose that RRM1 functions in activities that are more complex than UUU-3′OH binding. Accordingly, the RRM1 mutations also impair an RNA chaperone activity of La. The results suggest how La distinguishes precursor from product RNAs, allowing it to recycle onto a new pre-tRNA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Structural & Molecular Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFER RNA
KW - RNA metabolism
KW - RNA-protein interactions
KW - PROTEIN precursors
KW - MUTATION (Biology)
N1 - Accession Number: 37279005; Bayfield, Mark A. 1,2 Maraia, Richard J. 1,3; Email Address: maraiar@mail.nih.gov; Affiliation: 1: Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 2: Department of Biology, York University, Toronto, ON, Canada 3: Commissioned Corps, US Public Health Service, Bethesda, Maryland, USA; Source Info: Apr2009, Vol. 16 Issue 4, p430; Subject Term: TRANSFER RNA; Subject Term: RNA metabolism; Subject Term: RNA-protein interactions; Subject Term: PROTEIN precursors; Subject Term: MUTATION (Biology); Number of Pages: 8p; Illustrations: 2 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1038/nsmb.1573
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37279005&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dwyer, Diane
T1 - Use infant heel warmers with care.
JO - Nursing
JF - Nursing
Y1 - 2009/04//
VL - 39
IS - 4
M3 - Article
SP - 59
EP - 59
SN - 03604039
AB - The article discusses the infant heel warmer, a device used to increase circulation before performing a heel stick on a neonate. Several cases of adverse events resulting from the device are presented. Safety precautions for using it are also explored including assessing skin integrity, using the manufacturer's instructions for activating it, and disposing of it after use.
KW - NEWBORN infants -- Care
KW - EQUIPMENT & supplies
KW - BLOOD analysis
KW - NURSING -- Practice
KW - MATERNITY nursing
KW - HOSPITALS -- Furniture, equipment, etc.
KW - SAFETY measures
N1 - Accession Number: 37567919; Dwyer, Diane 1; Affiliation: 1: Nurse-consultant, Center for Devices and Radiological Health, FDA, Rockville, Md.; Source Info: Apr2009, Vol. 39 Issue 4, p59; Subject Term: NEWBORN infants -- Care; Subject Term: EQUIPMENT & supplies; Subject Term: BLOOD analysis; Subject Term: NURSING -- Practice; Subject Term: MATERNITY nursing; Subject Term: HOSPITALS -- Furniture, equipment, etc.; Subject Term: SAFETY measures; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105506311
T1 - Device safety. Use infant heel warmers with care.
AU - Dwyer D
Y1 - 2009/04//
N1 - Accession Number: 105506311. Language: English. Entry Date: 20090515. Revision Date: 20150711. Publication Type: Journal Article; nursing interventions; pictorial. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Pediatric Care. NLM UID: 7600137.
KW - Burns -- Etiology -- In Infancy and Childhood
KW - Burns -- Prevention and Control -- In Infancy and Childhood
KW - Equipment Safety -- In Infancy and Childhood
KW - Heel
KW - Infant Warmers -- Adverse Effects
KW - Neonatal Nursing
KW - Infant
KW - Inpatients
SP - 59
EP - 59
JO - Nursing
JF - Nursing
JA - NURSING
VL - 39
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Center for Devices and Radiological Health, FDA, Rockville, MD
U2 - PMID: 19365226.
DO - 10.1097/01.NURSE.0000348421.57430.90
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105535720
T1 - Venomous spiders, snakes, and scorpions in the United States.
AU - Holve S
Y1 - 2009/04//
N1 - Accession Number: 105535720. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; USA. NLM UID: 0356657.
KW - Arachnids -- Classification
KW - Bites and Stings -- Drug Therapy
KW - Reptiles -- Classification
KW - Snake Bites -- Drug Therapy
KW - Spiders -- Classification
KW - Animals
KW - Antivenins -- Therapeutic Use
KW - Bites and Stings -- Diagnosis
KW - Bites and Stings -- Metabolism
KW - Child
KW - Child, Preschool
KW - Emergency Medical Services -- Methods
KW - Immunity
KW - Pediatrics -- Methods
KW - Severity of Illness Indices
KW - Snake Bites -- Diagnosis
KW - Snake Bites -- Metabolism
KW - Venoms
KW - Human
SP - 210
EP - 217
JO - Pediatric Annals
JF - Pediatric Annals
JA - PEDIATR ANN
VL - 38
IS - 4
CY - Thorofare, New Jersey
PB - SLACK Incorporated
SN - 0090-4481
AD - Indian Health Service, Tuba City Regional Health Care Corporation,Tuba City, Arizona 86045, USA. steve.holve@tchealth.org
U2 - PMID: 19455950.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Anh-Nhan Pham
AU - Jeffrey Wang
AU - Jialong Fang
AU - Xin Gao
AU - Yilong Zhang
AU - Paul Blower
AU - Wolfgang Sadée
AU - Ying Huang
T1 - Pharmacogenomics Approach Reveals MRP1 (ABCC1)-Mediated Resistance to Geldanamycins.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2009/04//
VL - 26
IS - 4
M3 - Article
SP - 936
EP - 945
SN - 07248741
AB - Abstract Purpose Geldanamycin and its analogues belong to a new class of anticancer agents that inhibit the molecular chaperone heat shock protein 90. We hypothesized that membrane transporters expressed on tumor cells may contribute at least in part to cellular sensitivity to these agents. The purpose of this study is to identify novel transporters as determinant for sensitivity and resistance to geldanamycins. Methods To facilitate a systematic study of chemosensitivity across multiple geldanamycin analogues, we correlated mRNA expression profiles of majority of transporters with anticancer drug activities in 60 human tumor cell lines (NCI-60). We subsequently validated the gene–drug correlations using cytotoxicity and transport assays. Results The GA analogues displayed negative correlations with mRNA expression levels of the multidrug resistance protein 1 (MRP1, ABCC1). Suppressing MRP1 efflux using the inhibitor MK-571 and small interfering RNA in cell lines with intrinsic and acquired MRP1 overexpression (A549 and HL-60/ADR) and in cell lines stably transduced with MRP1 (MCF7/MRP1) increased intracellular drug accumulation and increased tumor cell sensitivity to geldanamycin analogues. Conclusions These results suggest that elevated expression of MRP1, like the alternative efflux transporter MDR1 (ABCB1, P-glycoprotein), can significantly influence tumor cell sensitivity to geldanamycins as a potential chemoresistance factor. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - MULTIDRUG resistance
KW - ANTINEOPLASTIC agents
KW - HEAT shock proteins
KW - MOLECULAR chaperones
KW - MESSENGER RNA
KW - CELL lines
N1 - Accession Number: 36783635; Anh-Nhan Pham 1 Jeffrey Wang 1 Jialong Fang 2 Xin Gao 3 Yilong Zhang 4 Paul Blower 5 Wolfgang Sadée 5 Ying Huang 1; Affiliation: 1: Western University of Health Sciences Department of Pharmaceutical Sciences, College of Pharmacy Pomona California 91766 USA 2: Food and Drug Administration Division of Biochemical Toxicology, National Center for Toxicological Research Jefferson Arkansas 72079 USA 3: York University Department of Mathematics and Statistics Toronto L4E OA1 Canada 4: Allergan Clinical Pharmacokinetics Department Irvine California 92612 USA 5: The Ohio State University Program of Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center, College of Medicine and Public Health Columbus Ohio 43210 USA; Source Info: Apr2009, Vol. 26 Issue 4, p936; Subject Term: PHARMACOGENOMICS; Subject Term: MULTIDRUG resistance; Subject Term: ANTINEOPLASTIC agents; Subject Term: HEAT shock proteins; Subject Term: MOLECULAR chaperones; Subject Term: MESSENGER RNA; Subject Term: CELL lines; Number of Pages: 10p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rowan, Christopher
AU - Brinker, Allen D.
AU - Nourjah, Parivash
AU - Chang, Jennie
AU - Mosholder, Andrew
AU - Barrett, Jeffrey S.
AU - Avigan, Mark
T1 - Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/04//
VL - 18
IS - 4
M3 - Article
SP - 301
EP - 309
SN - 10538569
AB - Purpose To assess spontaneous reports of rhabdomyolysis associated with simvastatin (SV) and pravastatin (PV) for evidence of CYP3A4 interaction. Clinical trial results advocate cholesterol lowering in high-risk patients including diabetics and the elderly. Given the association between advancing age, metabolic, and cardiovascular disease, many patients are treated with concomitant medications upon statin initiation. Although statins are generally safe, minor and severe adverse reactions arise, especially when given to patients taking concomitant medications that inhibit the statin clearance and lead to increased statin plasma concentration. Methods We conducted a comparative case series of rhabdomyolysis reports associated with SV and PV. Domestic spontaneous reports were obtained from the FDA's Adverse Event Reporting System (AERS). Drug utilization data were obtained from IMS HEALTH and the National Ambulatory Medical Care Survey (NAMCS). Adverse event reporting rates (AER) and ratios (AERR) of rhabdomyolysis associated with SV and PV-with and without stratification by CYP3A4 inhibitor concomitancy were determined. Results Stratification by CYP3A4 inhibitor concomitancy did not change the rhabdomyolysis AER for PV with or without a CYP3A4 inhibitor (2.4 cases and 3.1 cases per 10 million Rx, respectively). However, stratification of SV reports with or without a concomitant CYP3A4 inhibitor resulted in a rhabdomyolysis AER (38.4 and 6.0 cases per 10 million Rx, respectively). The corresponding AERR with or without a CYP3A4 inhibitor were 0.77 for PV and 6.43 for SV. Conclusions Spontaneous adverse event reports provide evidence of increased risk for rhabdomyolysis based on interaction between SV and selected CYP3A4 inhibitors. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707204; Rowan, Christopher 1; Brinker, Allen D. 2; Nourjah, Parivash 2; Chang, Jennie 2; Mosholder, Andrew 2; Barrett, Jeffrey S. 3; Avigan, Mark 2; Affiliations: 1: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA; 2: Division of Drug Risk Evaluation, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; 3: Laboratory for Applied PK/PD, Clinical Pharmacology & Therapeutics Division. The Children's Hospital of Philadelphia USA; Issue Info: Apr2009, Vol. 18 Issue 4, p301; Number of Pages: 9p; Document Type: Article
L3 - 10.1002/pds.1711
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Coelho, Sergio G.
AU - Zhou, Yanchun
AU - Bushar, Harry F.
AU - Miller, Sharon A.
AU - Zmudzka, Barbara Z.
AU - Hearing, Vincent J.
AU - Beer, Janusz Z.
T1 - Long-lasting pigmentation of human skin, a new look at an overlooked response to UV.
JO - Pigment Cell & Melanoma Research
JF - Pigment Cell & Melanoma Research
Y1 - 2009/04//
VL - 22
IS - 2
M3 - Letter
SP - 238
EP - 241
PB - Wiley-Blackwell
SN - 17551471
AB - A letter to the editor is presented in response to the article "Long-lasting pigmentation of human skin, a new look at an overlooked response to UV," by G. Sergio et al in issue 22.
KW - LETTERS to the editor
KW - HUMAN skin color
KW - long-lasting pigmentation
KW - melanogenesis
KW - ultraviolet radiation
N1 - Accession Number: 36880338; Coelho, Sergio G. 1 Zhou, Yanchun 2 Bushar, Harry F. 2 Miller, Sharon A. 2 Zmudzka, Barbara Z. 2 Hearing, Vincent J. 1 Beer, Janusz Z. 2; Affiliation: 1: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 2: Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA; Source Info: Apr2009, Vol. 22 Issue 2, p238; Subject Term: LETTERS to the editor; Subject Term: HUMAN skin color; Author-Supplied Keyword: long-lasting pigmentation; Author-Supplied Keyword: melanogenesis; Author-Supplied Keyword: ultraviolet radiation; Number of Pages: 4p; Illustrations: 1 Diagram, 1 Chart, 2 Graphs; Document Type: Letter
L3 - 10.1111/j.1755-148X.2009.00550.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khurana, Surender
AU - Suguitan Jr., Amorsolo L.
AU - Rivera, Yonaira
AU - Simmons, Cameron P.
AU - Lanzavecchia, Antonio
AU - Sallusto, Federica
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Subbarao, Kanta
AU - Golding, Hana
T1 - Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets.
JO - PLoS Medicine
JF - PLoS Medicine
Y1 - 2009/04//
VL - 6
IS - 4
M3 - Article
SP - 1
EP - 13
PB - Public Library of Science
SN - 15491277
AB - Background: Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics. Methods and Findings: To address this need, we generated whole-genome-fragment phage display libraries (GFPDL) expressing fragments of 15-350 amino acids covering all the proteins of A/Vietnam/1203/2004 (H5N1). These GFPDL were used to analyze neutralizing human monoclonal antibodies and sera of five individuals who had recovered from H5N1 infection. This approach led to the mapping of two broadly neutralizing human monoclonal antibodies with conformationdependent epitopes. In H5N1 convalescent sera, we have identified several potentially protective H5N1-specific human antibody epitopes in H5 HA[(-10)-223], neuraminidase catalytic site, and M2 ectodomain. In addition, for the first time to our knowledge in humans, we identified strong reactivity against PB1-F2, a putative virulence factor, following H5N1 infection. Importantly, novel epitopes were identified, which were recognized by H5N1-convalescent sera but did not react with sera from control individuals (H5N1 naïve, H1N1 or H3N2 seropositive). Conclusion: This is the first study, to our knowledge, describing the complete antibody repertoire following H5N1 infection. Collectively, these data will contribute to rational vaccine design and new H5N1-specific serodiagnostic surveillance tools. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Medicine is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA fingerprinting
KW - INFLUENZA A virus, H5N1 subtype
KW - COMMUNICABLE diseases -- Transmission
KW - MONOCLONAL antibodies
KW - IMMUNE response -- Regulation
KW - AVIAN influenza
KW - GENE expression
KW - GENE mapping
N1 - Accession Number: 45628338; Khurana, Surender 1 Suguitan Jr., Amorsolo L. 2 Rivera, Yonaira 1 Simmons, Cameron P. 3 Lanzavecchia, Antonio 4 Sallusto, Federica 4 Manischewitz, Jody 1 King, Lisa R. 1 Subbarao, Kanta 2 Golding, Hana 1; Email Address: hana.golding@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, United States of America 2: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America 3: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 4: Institute for Research in Biomedicine, Bellinzona, Switzerland; Source Info: Apr2009, Vol. 6 Issue 4, p1; Subject Term: DNA fingerprinting; Subject Term: INFLUENZA A virus, H5N1 subtype; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: MONOCLONAL antibodies; Subject Term: IMMUNE response -- Regulation; Subject Term: AVIAN influenza; Subject Term: GENE expression; Subject Term: GENE mapping; Number of Pages: 13p; Illustrations: 1 Diagram, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1371/journal.pmed.1000049
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105509632
T1 - Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.
AU - Khurana S
AU - Suguitan AL
AU - Rivera Y
AU - Simmons CP
AU - Lanzavecchia A
AU - Sallusto F
AU - Manischewitz J
AU - King LR
AU - Subbarao K
AU - Golding H
AU - Khurana, Surender
AU - Suguitan, Amorsolo L Jr
AU - Rivera, Yonaira
AU - Simmons, Cameron P
AU - Lanzavecchia, Antonio
AU - Sallusto, Federica
AU - Manischewitz, Jody
AU - King, Lisa R
AU - Subbarao, Kanta
AU - Golding, Hana
Y1 - 2009/04//
N1 - Accession Number: 105509632. Language: English. Entry Date: 20090522. Revision Date: 20161125. Publication Type: journal article; research. Commentary: Yen HL, Peiris JS. Mapping Antibody Epitopes of the Avian H5N1 Influenza Virus. (PLOS MED) Apr2009; 6 (4): e1000064-e1000064. Journal Subset: Biomedical; USA. Grant Information: //Intramural NIH HHS/United States. NLM UID: 101231360.
KW - Antigens -- Blood
KW - Antigens, Viral -- Immunology
KW - Influenza A Virus, H5N1 Subtype -- Immunology
KW - Influenza Vaccine -- Immunology
KW - Influenza, Avian -- Immunology
KW - Proteins -- Immunology
KW - Animals
KW - Antibodies, Monoclonal -- Diagnostic Use
KW - Birds
KW - Genome
KW - Glycoside Hydrolases -- Immunology
KW - Immunologic Techniques
KW - Influenza A Virus -- Immunology
KW - Influenza A Virus, H5N1 Subtype
KW - Influenza, Avian
KW - Proteins -- Antagonists and Inhibitors
KW - Recovery
KW - Toxins
KW - Vietnam
SP - e1000049
EP - e1000049
JO - PLoS Medicine
JF - PLoS Medicine
JA - PLOS MED
VL - 6
IS - 4
CY - San Francisco, California
PB - Public Library of Science
AB - Background: Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics.Methods and Findings: To address this need, we generated whole-genome-fragment phage display libraries (GFPDL) expressing fragments of 15-350 amino acids covering all the proteins of A/Vietnam/1203/2004 (H5N1). These GFPDL were used to analyze neutralizing human monoclonal antibodies and sera of five individuals who had recovered from H5N1 infection. This approach led to the mapping of two broadly neutralizing human monoclonal antibodies with conformation-dependent epitopes. In H5N1 convalescent sera, we have identified several potentially protective H5N1-specific human antibody epitopes in H5 HA[(-10)-223], neuraminidase catalytic site, and M2 ectodomain. In addition, for the first time to our knowledge in humans, we identified strong reactivity against PB1-F2, a putative virulence factor, following H5N1 infection. Importantly, novel epitopes were identified, which were recognized by H5N1-convalescent sera but did not react with sera from control individuals (H5N1 naïve, H1N1 or H3N2 seropositive).Conclusion: This is the first study, to our knowledge, describing the complete antibody repertoire following H5N1 infection. Collectively, these data will contribute to rational vaccine design and new H5N1-specific serodiagnostic surveillance tools.
SN - 1549-1277
AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, USA
U2 - PMID: 19381279.
DO - 10.1371/journal.pmed.1000049
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Crill, Wayne D.
AU - Hughes, Holly R.
AU - Delorey, Mark J.
AU - Chang, Gwong-Jen J.
T1 - Humoral Immune Responses of Dengue Fever Patients Using Epitope-Specific Serotype-2 Virus-Like Particle Antigens.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/04//
VL - 4
IS - 4
M3 - Article
SP - 1
EP - 18
PB - Public Library of Science
SN - 19326203
AB - Dengue virus (DENV) is a serious mosquito-borne pathogen causing significant global disease burden, either as classic dengue fever (DF) or in its most severe manifestation dengue hemorrhagic fever (DHF). Nearly half of the world's population is at risk of dengue disease and there are estimated to be millions of infections annually; a situation which will continue to worsen with increasing expansion of the mosquito vectors and epidemic DF/DHF. Currently there are no available licensed vaccines or antivirals for dengue, although significant effort has been directed toward the development of safe and efficacious dengue vaccines for over 30 years. Promising vaccine candidates are in development and testing phases, but a better understanding of immune responses to DENV infection and vaccination is needed. Humoral immune responses to DENV infection are complex and may exacerbate pathogenicity, yet are essential for immune protection. In this report, we develop DENV-2 envelope (E) protein epitope-specific antigens and measure immunoglobulin responses to three distinct epitopes in DENV-2 infected human serum samples. Immunoglobulin responses to DENV-2 infection exhibited significant levels of individual variation. Antibody populations targeting broadly cross-reactive epitopes centered on the fusion peptide in structural domain II were large, highly variable, and greater in primary than in secondary DENV-2 infected sera. E protein domain III cross-reactive immunoglobulin populations were similarly variable and much larger in IgM than in IgG. DENV-2 specific domain III IgG formed a very small proportion of the antibody response yet was significantly correlated with DENV-2 neutralization, suggesting that the highly protective IgG recognizing this epitope in murine studies plays a role in humans as well. This report begins to tease apart complex humoral immune responses to DENV infection and is thus important for improving our understanding of dengue disease and immunological correlates of protection, relevant to DENV vaccine development and testing. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENGUE
KW - VACCINATION
KW - IMMUNE response
KW - DENGUE hemorrhagic fever
KW - MOSQUITOES as carriers of disease
KW - INSECTS as carriers of disease
KW - IMMUNOGLOBULINS
KW - IMMUNOGLOBULIN genes
KW - BLOOD proteins
KW - ANTIGENS
N1 - Accession Number: 55982205; Crill, Wayne D. 1; Email Address: wcrill@cdc.gov Hughes, Holly R. 1 Delorey, Mark J. 1 Chang, Gwong-Jen J. 1; Affiliation: 1: Arbovirus Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U. S. Department of Health and Human Service, Fort Collins, Colorado, United States of America; Source Info: 2009, Vol. 4 Issue 4, p1; Subject Term: DENGUE; Subject Term: VACCINATION; Subject Term: IMMUNE response; Subject Term: DENGUE hemorrhagic fever; Subject Term: MOSQUITOES as carriers of disease; Subject Term: INSECTS as carriers of disease; Subject Term: IMMUNOGLOBULINS; Subject Term: IMMUNOGLOBULIN genes; Subject Term: BLOOD proteins; Subject Term: ANTIGENS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 18p; Illustrations: 2 Diagrams, 8 Charts, 1 Graph; Document Type: Article
L3 - 10.1371/journal.pone.0004991
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reynolds, Mary G.
AU - Holman, Robert C.
AU - Yorita Christensen, Krista L.
AU - Cheek, James E.
AU - Damon, Inger K.
T1 - The Incidence of Molluscum contagiosum among American Indians and Alaska Natives.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/04//
VL - 4
IS - 4
M3 - Article
SP - 1
EP - 8
PB - Public Library of Science
SN - 19326203
AB - Background: The epidemiology of Molluscum contagiosum (MC) in the United States is largely unknown, despite the fact that the virus is directly communicable and large outbreaks occur. This study provides population-based estimates to describe the epidemiology of MC in the United States among American Indian and Alaska Native (AI/AN) persons. This population was selected because of the comprehensiveness and quality of available data describing utilization of outpatient services. Principal Findings: Outpatient visits listing MC as a diagnosis in the Indian Health Service National Patient Information Reporting System during 2001-2005 were analyzed to assess patient characteristics, visit frequency and concurrent skin conditions. Outpatient visit rates and incidence rates were calculated based on known population denominators (retrospective cohort). Overall outpatient visit rates were also calculated for the general US population using national data. The average annual rate of MC-associated outpatient visits was 20.15/10,000 AI/AN persons for 2001-2005 (13,711 total visits), which was similar to the rate for the general US population (22.0/10,000 [95% CI: 16.9-27.1]). The incidence of MCassociated visits was 15.34/10,000. AI/AN children 1-4 years old had the highest incidence (77.12), more than twice that for children 5-14 years old (30.79); the incidence for infants (,1 year) was higher than that for adults. AI/AN persons living in the West region had the highest incidence, followed by those in the East and Alaska regions (26.96, 22.88 and 21.38, respectively). There were age-specific associations between MC and concurrent skin conditions (e.g., atopic dermatitis, eczema). Conclusions: This study highlights the need for periodic population-based measurements to assess trends in incidence and healthcare utilization for MC in the United States. High rates of MC were found among AI/AN persons, especially among children ,15 years old. The AI/AN population would benefit from greater availability of effective strategies for prevention and treatment of MCV infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - VIRUS diseases
KW - SKIN diseases
KW - COMMUNICABLE diseases -- Transmission
KW - PREVENTION
KW - PUBLIC health -- United States
KW - NATIVE Americans
KW - ALASKA Natives
KW - UNITED States
N1 - Accession Number: 55982425; Reynolds, Mary G. 1; Email Address: nzr6@cdc.gov Holman, Robert C. 2 Yorita Christensen, Krista L. 2 Cheek, James E. 3 Damon, Inger K. 1; Affiliation: 1: Poxvirus and Rabies Branch, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America 2: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America 3: Division of Epidemiology and Prevention, Office of Public Health Support, Indian Health Service, USDHHS, Albuquerque, New Mexico, United States of America; Source Info: 2009, Vol. 4 Issue 4, p1; Subject Term: EPIDEMIOLOGY; Subject Term: VIRUS diseases; Subject Term: SKIN diseases; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: PREVENTION; Subject Term: PUBLIC health -- United States; Subject Term: NATIVE Americans; Subject Term: ALASKA Natives; Subject Term: UNITED States; Number of Pages: 8p; Illustrations: 4 Charts, 4 Graphs, 1 Map; Document Type: Article
L3 - 10.1371/journal.pone.0005255a
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schnell, Gretja
AU - Spudich, Serena
AU - Harrington, Patrick
AU - Price, Richard W.
AU - Swanstrom, Ronald
T1 - Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1-Associated Dementia.
JO - PLoS Pathogens
JF - PLoS Pathogens
Y1 - 2009/04//
VL - 5
IS - 4
M3 - Article
SP - 1
EP - 13
PB - Public Library of Science
SN - 15537366
AB - Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) shortly after systemic infection and can result in the subsequent development of HIV-1-associated dementia (HAD) in a subset of infected individuals. Genetically compartmentalized virus in the CNS is associated with HAD, suggesting autonomous viral replication as a factor in the disease process. We examined the source of compartmentalized HIV-1 in the CNS of subjects with HIV-1-associated neurological disease and in asymptomatic subjects who were initiating antiretroviral therapy. The heteroduplex tracking assay (HTA), targeting the variable regions of env, was used to determine which HIV-1 genetic variants in the cerebrospinal fluid (CSF) were compartmentalized and which variants were shared with the blood plasma. We then measured the viral decay kinetics of individual variants after the initiation of antiretroviral therapy. Compartmentalized HIV-1 variants in the CSF of asymptomatic subjects decayed rapidly after the initiation of antiretroviral therapy, with a mean half-life of 1.57 days. Rapid viral decay was also measured for CSF-compartmentalized variants in four HAD subjects (t½ mean = 2.27 days). However, slow viral decay was measured for CSF-compartmentalized variants from an additional four subjects with neurological disease (t½ range = 9.85 days to no initial decay). The slow decay detected for CSF-compartmentalized variants was not associated with poor CNS drug penetration, drug resistant virus in the CSF, or the presence of X4 virus genotypes. We found that the slow decay measured for CSF-compartmentalized variants in subjects with neurological disease was correlated with low peripheral CD4 cell count and reduced CSF pleocytosis. We propose a model in which infiltrating macrophages replace CD4+ T cells as the primary source of productive viral replication in the CNS to maintain high viral loads in the CSF in a substantial subset of subjects with HAD. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Pathogens is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - CENTRAL nervous system -- Diseases
KW - DEMENTIA
KW - CEREBROSPINAL fluid
KW - CD4 antigen
KW - MACROPHAGES
KW - VIRUS diseases -- Treatment
N1 - Accession Number: 45437907; Schnell, Gretja 1 Spudich, Serena 2 Harrington, Patrick 3,4,5 Price, Richard W. 2 Swanstrom, Ronald 1,3,4; Email Address: risunc@med.unc.edu; Affiliation: 1: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America 2: Department of Neurology, University of California at San Francisco, San Francisco General Hospital, San Francisco, California, United States of America 3: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America 4: UNC Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina, United States of America 5: United States Food and Drug Administration, Center for Drug Evaluation and Research, Division of Antiviral Products, Silver Spring, Maryland, United States of America; Source Info: Apr2009, Vol. 5 Issue 4, p1; Subject Term: HIV (Viruses); Subject Term: CENTRAL nervous system -- Diseases; Subject Term: DEMENTIA; Subject Term: CEREBROSPINAL fluid; Subject Term: CD4 antigen; Subject Term: MACROPHAGES; Subject Term: VIRUS diseases -- Treatment; Number of Pages: 13p; Illustrations: 1 Black and White Photograph, 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1371/journal.ppat.1000395
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45437907&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105478337
T1 - Body weight dissatisfaction among Israeli Jewish and Arab women with normal or overweight-obese body mass index, Israeli INHIS-1, 2003-2004.
AU - Niskar A
AU - Baron-Epel O
AU - Garty-Sandalon N
AU - Keinan-Boker L
AU - Niskar, Amanda
AU - Baron-Epel, Orna
AU - Garty-Sandalon, Noga
AU - Keinan-Boker, Lital
Y1 - 2009/04//2009 Apr
N1 - Accession Number: 105478337. Language: English. Entry Date: 20090619. Revision Date: 20160320. Publication Type: journal article; research. Journal Subset: Blind Peer Reviewed; Expert Peer Reviewed; Health Promotion/Education; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Instrumentation: National Health Interview Survey (NHIS). NLM UID: 101205018.
KW - Obesity -- Psychosocial Factors
KW - Personal Satisfaction
KW - Adult
KW - Aged
KW - Arabs
KW - Body Image
KW - Culture
KW - Data Collection
KW - Female
KW - Interview Guides
KW - Israel
KW - Jews
KW - Middle Age
KW - Socioeconomic Factors
KW - Human
SP - A51
EP - A51
JO - Preventing Chronic Disease
JF - Preventing Chronic Disease
JA - PREV CHRONIC DIS
VL - 6
IS - 2
CY - Atlanta, Georgia
PB - National Center for Chronic Disease Prevention & Health Promotion
AB - Introduction: In Israel, 58.9% of Jewish and Arab Israeli women aged 25 to 64 years are overweight or obese (body mass index >or=25 kg/m(2)). The objective of this analysis is to describe body weight dissatisfaction differences between Jewish and Arab Israeli women with normal or overweight-obese body mass index.Methods: This analysis included 1,393 Jewish and Arab women who participated in the Israeli National Health Interview Survey, 2003-2004. The survey covered a random sample of the Israeli general population aged 21 years or older. All variables were based on self-report. Body weight dissatisfaction was a multiple-choice question in the survey that offered the following responses: very satisfied, satisfied, reasonably satisfied, not satisfied, or very unsatisfied. Univariate and multivariate analyses were conducted.Results: Overall, 39.1% of Jewish women reported body weight dissatisfaction, compared with 29.1% of Arab women. Older overweight-obese Arab women had a lower prevalence of body weight dissatisfaction than Jewish women of the same age group, which indicates cultural differences in body weight dissatisfaction among older overweight-obese women. However, cultural differences do not appear to influence body weight dissatisfaction among younger Jewish and Arab women of normal weight.Conclusion: This study suggests that Jewish and Arab women differ in their perceptions of body weight. Interventions tailored to each group are needed to promote healthy dietary and physical activity behaviors.
SN - 1545-1151
AD - Tel Aviv University, Tel Aviv, Israel
AD - Tel Aviv University, Tel Aviv, Israel. amanda.niskar@hhs.gov
U2 - PMID: 19288994.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105506855
T1 - Delivery of excellent mental health care and acceleration of research: federal activities since the President's Commission report.
AU - Hennessy KD
AU - Chambers DA
Y1 - 2009/04//
N1 - Accession Number: 105506855. Language: English. Entry Date: 20090605. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Psychiatry/Psychology. NLM UID: 9502838.
KW - Health Manpower -- Administration
KW - Knowledge
KW - Mental Health Organizations
KW - Mental Health Services -- Administration -- United States
KW - National Institute of Mental Health (U.S.)
KW - Professional Practice, Evidence-Based
KW - Quality of Health Care
KW - Research, Mental Health
KW - Substance Abuse and Mental Health Services Administration
KW - Grants
KW - Mental Disorders -- Rehabilitation
KW - United States
SP - 433
EP - 438
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 60
IS - 4
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - The report of the President's New Freedom Commission set forth six goals and related recommendations to enable adults with serious mental illness and children with serious emotional disturbance to participate fully in their communities. This article focuses on goal 5--'Excellent mental health care is delivered and research is accelerated'--and its four related recommendations. The authors describe federal government activities undertaken since the report was released. To accelerate research, the National Institute of Mental Health (NIMH) has launched initiatives to find ways to interrupt the progress of schizophrenia and to identify interventions for combat veterans with mental health problems. To advance evidence-based practices, the Substance Abuse and Mental Health Services Administration (SAMHSA) has expanded and transformed its National Registry of Evidence-Based Programs and Practices and NIMH has launched a major research initiative to build the knowledge base for dissemination and implementation. To improve and expand the workforce, SAMHSA has published an action plan for workforce development and NIMH has established grants to develop curricula to integrate training in evidence-based practices into clinical training programs. To develop knowledge in understudied areas, NIMH has funded studies to reduce and eliminate disparities and SAMHSA has supported efforts to improve delivery of trauma-informed services, such as the National Child Traumatic Stress Network. Continued advancement in goal 5 areas calls for commitment to working across agency and organizational boundaries to ensure more rapid and widespread dissemination and implementation of research and policies and for further development of ways to promote the participation of all stakeholders.
SN - 1075-2730
AD - Office of Policy, Planning, and Budget, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Rockville, MD 20857, USA. kevin.hennessy@samhsa.hhs.gov
U2 - PMID: 19339316.
DO - 10.1176/appi.ps.60.4.433
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105506855&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wideroff, Louise
AU - Phillips, Kathryn A.
AU - Randhawa, Gurvaneet
AU - Ambs, Anita
AU - Armstrong, Katrina
AU - Bennett, Charles L.
AU - Brown, Martin L.
AU - Donaldson, Molla S.
AU - Follen, Michele
AU - Goldie, Sue J.
AU - Hiatt, Robert A.
AU - Khoury, Muin J.
AU - Lewis, Graham
AU - McLeod, Howard L.
AU - Piper, Margaret
AU - Powell, Isaac
AU - Schrag, Deborah
AU - Schulman, Kevin A.
AU - Scott, Joan
T1 - A Health Services Research Agenda for Cellular, Molecular and Genomic Technologies in Cancer Care.
JO - Public Health Genomics
JF - Public Health Genomics
Y1 - 2009/04//
VL - 12
IS - 4
M3 - Article
SP - 233
EP - 244
SN - 16624246
AB - Background: In recent decades, extensive resources have been invested to develop cellular, molecular and genomic technologies with clinical applications that span the continuum of cancer care. Methods: In December 2006, the National Cancer Institute sponsored the first workshop to uniquely examine the state of health services research on cancer-related cellular, molecular and genomic technologies and identify challenges and priorities for expanding the evidence base on their effectiveness in routine care. Results: This article summarizes the workshop outcomes, which included development of a comprehensive research agenda that incorporates health and safety endpoints, utilization patterns, patient and provider preferences, quality of care and access, disparities, economics and decision modeling, trends in cancer outcomes, and health-related quality of life among target populations. Conclusions: Ultimately, the successful adoption of useful technologies will depend on understanding and influencing the patient, provider, health care system and societal factors that contribute to their uptake and effectiveness in ‘real-world’ settings. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Genomics is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER treatment
KW - CANCER -- Alternative treatment
KW - CANCER -- Gene therapy
KW - CHEMOTHERAPY (Cancer)
KW - CANCER -- Immunotherapy
KW - Emerging technologies
KW - Genomics
KW - Health services research
KW - Translational research
N1 - Accession Number: 37580810; Wideroff, Louise 1; Email Address: Wideroff@nih.gov Phillips, Kathryn A. 2 Randhawa, Gurvaneet 3 Ambs, Anita 1 Armstrong, Katrina 4 Bennett, Charles L. 5 Brown, Martin L. 1 Donaldson, Molla S. 6 Follen, Michele 7 Goldie, Sue J. 8 Hiatt, Robert A. 2 Khoury, Muin J. 9 Lewis, Graham 10 McLeod, Howard L. 11 Piper, Margaret 12 Powell, Isaac 13 Schrag, Deborah 14 Schulman, Kevin A. 15 Scott, Joan 16; Affiliation: 1: National Cancer Institute, Bethesda, Md. 2: University of California, San Francisco, San Francisco, Calif. 3: Agency for Healthcare Research and Quality, Rockville, Md. 4: University of Pennsylvania, Philadelphia, Pa. 5: Northwestern University, Evanston, Ill. 6: George Washington University, Washington, D.C. 7: M. D. Anderson Cancer Center, Houston, Tex. 8: Harvard University, Boston, Mass. 9: Centers for Disease Control and Prevention, Atlanta, Ga. 10: University of York, Heslington, UK 11: University of North Carolina, Chapel Hill, N.C. 12: Blue Cross Blue Shield Association Technology Evaluation Center, Chicago, Ill. 13: Wayne State University, Detroit, Mich. 14: Dana Farber Cancer Institute, Boston, Mass. 15: Duke University, Durham, N.C. 16: Johns Hopkins University, Baltimore, Md., USA; Source Info: 2009, Vol. 12 Issue 4, p233; Subject Term: CANCER treatment; Subject Term: CANCER -- Alternative treatment; Subject Term: CANCER -- Gene therapy; Subject Term: CHEMOTHERAPY (Cancer); Subject Term: CANCER -- Immunotherapy; Author-Supplied Keyword: Emerging technologies; Author-Supplied Keyword: Genomics; Author-Supplied Keyword: Health services research; Author-Supplied Keyword: Translational research; Number of Pages: 12p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1159/000203779
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37580810&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - KING, ANNA
AU - MARUNA, SHADD
T1 - Is a conservative just a liberal who has been mugged?
JO - Punishment & Society
JF - Punishment & Society
Y1 - 2009/04//
VL - 11
IS - 2
M3 - Article
SP - 147
EP - 169
SN - 14624745
AB - As in the adage that 'a conservative is just a liberal who has been mugged', many presume that punitive public attitudes are derived from the direct experience of crime and victimization. People become 'fed up' with criminality and seek to strike back at lawbreakers. Social theories of punitiveness, on the other hand, typically portray punitiveness as a form of scape-goating in which offenders are just a stand-in population, masking more abstract anxieties. This survey was designed to explore both of these hypotheses with a sample (N = 940) of the British public. A multivariate analysis of survey responses finds that factors such as concerns about the economy and the state of 'the youth today' account for a substantial proportion of the effect of actual crime concerns on punitiveness. Crime-related factors, such as victimization experiences or anxieties about crime, on the other hand, do not appear to be strong predictors of punitiveness in this sample. [ABSTRACT FROM AUTHOR]
AB - Copyright of Punishment & Society is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUNISHMENT (Psychology)
KW - ANXIETY
KW - SURVEYS
KW - PUBLIC opinion
KW - CRIME
KW - GREAT Britain
KW - conservativism
KW - public opinion
KW - punitiveness
KW - sentencing
N1 - Accession Number: 37375063; KING, ANNA 1 MARUNA, SHADD 2; Affiliation: 1: Post-Doctoral Research Fellow, Center for Mental Health Services and Criminal Justice Research, Rutgers University. 2: Professor of Justice and Human Development, Queen's University Belfast.; Source Info: Apr2009, Vol. 11 Issue 2, p147; Subject Term: PUNISHMENT (Psychology); Subject Term: ANXIETY; Subject Term: SURVEYS; Subject Term: PUBLIC opinion; Subject Term: CRIME; Subject Term: GREAT Britain; Author-Supplied Keyword: conservativism; Author-Supplied Keyword: public opinion; Author-Supplied Keyword: punitiveness; Author-Supplied Keyword: sentencing; Number of Pages: 23p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105491806
T1 - Noncalcified lung nodules: volumetric assessment with thoracic CT.
AU - Gavrielides MA
AU - Kinnard LM
AU - Myers KJ
AU - Petrick N
AU - Gavrielides, Marios A
AU - Kinnard, Lisa M
AU - Myers, Kyle J
AU - Petrick, Nicholas
Y1 - 2009/04//2009 Apr
N1 - Accession Number: 105491806. Language: English. Entry Date: 20090508. Revision Date: 20161116. Publication Type: journal article; research. Journal Subset: Biomedical; USA. Special Interest: Diagnostic Imaging. Grant Information: //Intramural NIH HHS/United States. NLM UID: 0401260.
KW - Algorithms
KW - Diagnostic Imaging -- Methods
KW - Lung Neoplasms -- Radiography
KW - Radiographic Image Interpretation, Computer-Assisted -- Methods
KW - Radiography, Thoracic -- Methods
KW - Tomography, X-Ray Computed -- Methods
KW - Calcinosis -- Radiography
KW - Radiographic Image Enhancement -- Methods
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Human
SP - 26
EP - 37
JO - Radiology
JF - Radiology
JA - RADIOLOGY
VL - 251
IS - 1
CY - Oak Brook, Illinois
PB - Radiological Society of North America
AB - Lung nodule volumetry is used for nodule diagnosis, as well as for monitoring tumor response to therapy. Volume measurement precision and accuracy depend on a number of factors, including image-acquisition and reconstruction parameters, nodule characteristics, and the performance of algorithms for nodule segmentation and volume estimation. The purpose of this article is to provide a review of published studies relevant to the computed tomographic (CT) volumetric analysis of lung nodules. A number of underexamined areas of research regarding volumetric accuracy are identified, including the measurement of nonsolid nodules, the effects of pitch and section overlap, and the effect of respiratory motion. The need for public databases of phantom scans, as well as of clinical data, is discussed. The review points to the need for continued research to examine volumetric accuracy as a function of a multitude of interrelated variables involved in the assessment of lung nodules. Understanding and quantifying the sources of volumetric measurement error in the assessment of lung nodules with CT would be a first step toward the development of methods to minimize that error through system improvements and to correctly account for any remaining error.
SN - 0033-8419
AD - National Institute of Biomedical Imaging and Bioengineering/Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993-0002, USA
AD - National Institute of Biomedical Imaging and Bioengineering/Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993-0002, USA. marios.gavrielides@fda.hhs.gov
U2 - PMID: 19332844.
DO - 10.1148/radiol.2511071897
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105491806&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Delclos, K. Barry
AU - Weis, Constance C.
AU - Bucci, Thomas J.
AU - Olson, Greg
AU - Mellick, Paul
AU - Sadovova, Natalya
AU - Latendresse, John R.
AU - Thorn, Brett
AU - Newbold, Retha R.
T1 - Overlapping but distinct effects of genistein and ethinyl estradiol (EE2) in female Sprague–Dawley rats in multigenerational reproductive and chronic toxicity studies
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2009/04//
VL - 27
IS - 2
M3 - Article
SP - 117
EP - 132
SN - 08906238
AB - Abstract: Genistein and ethinyl estradiol (EE2) were examined in multigenerational reproductive and chronic toxicity studies that had different treatment intervals among generations. Sprague–Dawley rats received genistein (0, 5, 100, or 500ppm) or EE2 (0, 2, 10, or 50ppb) in a low phytoestrogen diet. Nonneoplastic effects in females are summarized here. Genistein at 500ppm and EE2 at 50ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. At the high dose, anogenital distance was subtly affected by both compounds, and a reduction in litter size was evident in genistein-treated animals. Genistein at 500ppm induced an early onset of aberrant cycles relative to controls in the chronic studies. EE2 significantly increased the incidence of uterine lesions (atypical focal hyperplasia and squamous metaplasia). These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ETHINYL estradiol
KW - ISOFLAVONES
KW - SPRAGUE Dawley rats
KW - RATS as laboratory animals
KW - REPRODUCTION
KW - TOXICOLOGY
KW - PHYTOESTROGENS
KW - ESTRUS
KW - CHEMICALS -- Physiological effect
KW - Estrous cycle
KW - Ethinyl estradiol
KW - Genistein
KW - Multigenerational
KW - Puberty acceleration
KW - Rat
KW - Reproductive senescence
KW - Reproductive toxicity
KW - Soy-free diet
N1 - Accession Number: 37229074; Delclos, K. Barry 1; Email Address: barry.delclos@fda.hhs.gov Weis, Constance C. 1 Bucci, Thomas J. 2 Olson, Greg 2 Mellick, Paul 2 Sadovova, Natalya 2 Latendresse, John R. 2 Thorn, Brett 1 Newbold, Retha R. 3; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR 72079, United States 2: Toxicologic Pathology Associates, Jefferson, AR 72079, United States 3: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States; Source Info: Apr2009, Vol. 27 Issue 2, p117; Subject Term: ETHINYL estradiol; Subject Term: ISOFLAVONES; Subject Term: SPRAGUE Dawley rats; Subject Term: RATS as laboratory animals; Subject Term: REPRODUCTION; Subject Term: TOXICOLOGY; Subject Term: PHYTOESTROGENS; Subject Term: ESTRUS; Subject Term: CHEMICALS -- Physiological effect; Author-Supplied Keyword: Estrous cycle; Author-Supplied Keyword: Ethinyl estradiol; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Multigenerational; Author-Supplied Keyword: Puberty acceleration; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Reproductive senescence; Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Soy-free diet; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.reprotox.2008.12.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meganathan Kannan
T1 - An Update on the Prevalence and Characterization of H-PF4 Antibodies in Asian-Indian Patients.
JO - Seminars in Thrombosis & Hemostasis
JF - Seminars in Thrombosis & Hemostasis
Y1 - 2009/04//
VL - 35
IS - 3
M3 - Article
SP - 337
EP - 343
SN - 00946176
AB - Heparin is the second most widely used anticoagulant/antithrombotic agent besides warfarin and is commonly used for various purposes such as treatment and surgical indications. A significant adverse effect of heparin treatment can occur when heparin binds platelet factor 4 (H-PF4) to form a complex that results in formation of H-PF4 antibodies, which in turn leads to platelet/endothelial cell activation followed by heparin-induced thrombocytopenia (HIT). Based on the heparin-induced platelet aggregation and enzyme-linked immunosorbent assay tests, the H-PF4 antibody (HIT antibody) was diagnosed in 6% of Indian patients undergoing cardiovascular surgery who received unfractionated heparin, but the frequency of occurrence rose to 15% when the patients were tested with the 14C-serotonin release assay. This highlights some methodological variations in the diagnosis of HIT antibodies. It was also found that all the HIT-positive patients were either homozygous or heterozygous for the Fc?RIIa polymorphism, which also highlights the role of this polymorphism in the occurrence of HIT. Very recent studies show that increases in HIT antibody production may also be due to heparin contaminants. Although these antibodies do not result in thrombocytopenia, contaminants in heparin may be capable of triggering a differential immunogenic response in comparison with contaminant-free heparin. Here we discuss the methodological differences in diagnosing HIT, the potential impact of contaminants in heparin, as well as future considerations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Seminars in Thrombosis & Hemostasis is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTICOAGULANTS (Medicine)
KW - IMMUNOGLOBULINS
KW - POLYSACCHARIDES
KW - THROMBOCYTOPENIA
N1 - Accession Number: 39988912; Meganathan Kannan 1; Affiliation: 1: Postdoctoral fellow, Department of Hematology, All India Institute of Medical Sciences, New Delhi, India; and Division of Hematology, U.S. Food and Drug Administration, NIH, Bethesda, Maryland; Source Info: Apr2009, Vol. 35 Issue 3, p337; Subject Term: ANTICOAGULANTS (Medicine); Subject Term: IMMUNOGLOBULINS; Subject Term: POLYSACCHARIDES; Subject Term: THROMBOCYTOPENIA; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Cho, Minjung
AU - Jeong, Jinyoung
AU - Choi, Mina
AU - Cho, Hea-Young
AU - Han, Beom Seok
AU - Kim, Sheen Hee
AU - Kim, Hyoung Ook
AU - Lim, Yong Taik
AU - Chung, Bong Hyun
AU - Jeong, Jayoung
T1 - Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/04//
VL - 236
IS - 1
M3 - Article
SP - 16
EP - 24
SN - 0041008X
AB - Abstract: In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles were found to accumulate in the liver and spleen for up to 7 days after injection and to have long blood circulation times. In addition, transmission electron microscopy showed that numerous cytoplasmic vesicles and lysosomes of liver Kupffer cells and spleen macrophages contained the PEG-coated gold nanoparticles. These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICITY testing -- In vivo
KW - PHARMACOKINETICS
KW - COLLOIDAL gold
KW - SURFACE coatings
KW - BIOACCUMULATION
KW - HEPATITIS
KW - APOPTOSIS
KW - BIOMEDICAL materials
KW - Accumulation
KW - Gold nanoparticles
KW - Inflammation
KW - Intravenous injection
KW - Pharmacokinetics
N1 - Accession Number: 36967454; Cho, Wan-Seob 1 Cho, Minjung 1 Jeong, Jinyoung 2 Choi, Mina 1 Cho, Hea-Young 3 Han, Beom Seok 1 Kim, Sheen Hee 1 Kim, Hyoung Ook 1 Lim, Yong Taik 2 Chung, Bong Hyun 2; Email Address: chungbh@kribb.re.kr Jeong, Jayoung 1; Email Address: jjy_kfda@kfda.go.kr; Affiliation: 1: Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704 Republic of Korea 2: Nanobiotechnology, BioNanotechnology Research Center, School of Engineering, Korea University of Science and Technology, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806 Republic of Korea 3: Division of Safety Pharmacology, Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704 Republic of Korea; Source Info: Apr2009, Vol. 236 Issue 1, p16; Subject Term: TOXICITY testing -- In vivo; Subject Term: PHARMACOKINETICS; Subject Term: COLLOIDAL gold; Subject Term: SURFACE coatings; Subject Term: BIOACCUMULATION; Subject Term: HEPATITIS; Subject Term: APOPTOSIS; Subject Term: BIOMEDICAL materials; Author-Supplied Keyword: Accumulation; Author-Supplied Keyword: Gold nanoparticles; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Intravenous injection; Author-Supplied Keyword: Pharmacokinetics; NAICS/Industry Codes: 325510 Paint and Coating Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.taap.2008.12.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36967454&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gillum, Nikki
AU - Karabekian, Zaruhi
AU - Swift, Luther M.
AU - Brown, Ronald P.
AU - Kay, Matthew W.
AU - Sarvazyan, Narine
T1 - Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/04//
VL - 236
IS - 1
M3 - Article
SP - 25
EP - 38
SN - 0041008X
AB - Abstract: Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer found in a variety of polyvinyl chloride (PVC) medical products. The results of studies in experimental animals suggest that DEHP leached from flexible PVC tubing may cause health problems in some patient populations. While the cancerogenic and reproductive effects of DEHP are well recognized, little is known about the potential adverse impact of phthalates on the heart. This study examined the effects of clinically relevant concentrations of DEHP on neonatal rat cardiomyocytes. It was found that application of DEHP to a confluent, synchronously beating cardiac cell network, leads to a marked, concentration-dependent decrease in conduction velocity and asynchronous cell beating. The mechanism behind these changes was a loss of gap junctional connexin-43, documented using Western blot analysis, dye-transfer assay and immunofluorescence. In addition to its effect on electrical coupling, DEHP treatment also affected the mechanical movement of myocyte layers. The latter was linked to the decreased stiffness of the underlying fibroblasts, as the amount of triton-insoluble vimentin was significantly decreased in DEHP-treated samples. The data indicate that DEHP, in clinically relevant concentrations, can impair the electrical and mechanical behavior of a cardiac cell network. Applicability of these findings to human patients remains to be established. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHTHALATE esters
KW - MYOCARDIUM
KW - POLYVINYL chloride
KW - BIOMEDICAL materials
KW - PLASTICIZERS
KW - HEART -- Electric properties
KW - HEART -- Mechanical properties
KW - RATS as laboratory animals
KW - Cardiomyocytes
KW - Connexin
KW - Gap junction
KW - Phthalate
N1 - Accession Number: 36967455; Gillum, Nikki 1 Karabekian, Zaruhi 1 Swift, Luther M. 1 Brown, Ronald P. 2 Kay, Matthew W. 1,3 Sarvazyan, Narine 1; Email Address: phynas@gwumc.edu; Affiliation: 1: Pharmacology and Physiology Department, The George Washington University, 2300 Eye Street, Washington DC 20037, USA 2: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA 3: Electrical and Computer Engineering Department, The George Washington University, Washington DC, USA; Source Info: Apr2009, Vol. 236 Issue 1, p25; Subject Term: PHTHALATE esters; Subject Term: MYOCARDIUM; Subject Term: POLYVINYL chloride; Subject Term: BIOMEDICAL materials; Subject Term: PLASTICIZERS; Subject Term: HEART -- Electric properties; Subject Term: HEART -- Mechanical properties; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: Cardiomyocytes; Author-Supplied Keyword: Connexin; Author-Supplied Keyword: Gap junction; Author-Supplied Keyword: Phthalate; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 424610 Plastics Materials and Basic Forms and Shapes Merchant Wholesalers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325999 All other miscellaneous chemical product manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.taap.2008.12.027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36967455&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-03410-009
AN - 2009-03410-009
AU - Durant, Nefertiti H.
AU - Bartman, Barbara
AU - Person, Sharina D.
AU - Collins, Felicia
AU - Austin, S. Bryn
T1 - Patient provider communication about the health effects of obesity.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 2009/04//
VL - 75
IS - 1
SP - 53
EP - 57
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
AD - Durant, Nefertiti H., Division of General Pediatrics and Adolescent Medicine, Department of Medicine, MTC 201, 1600 7th Avenue South, Birmingham, AL, US, 35233
N1 - Accession Number: 2009-03410-009. PMID: 19038523 Partial author list: First Author & Affiliation: Durant, Nefertiti H.; Division of General Pediatrics and Adolescent Medicine, Department of Medicine, Birmingham, AL, US. Release Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Attitudes; Communication; Health; Obesity; Racial and Ethnic Differences. Minor Descriptor: Ethnic Identity; Overweight. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2009. Publication History: Accepted Date: Sep 17, 2008; Revised Date: Sep 11, 2008; First Submitted Date: Jan 8, 2008. Copyright Statement: All rights reserved. Elsevier Ireland Ltd. 2008.
AB - Objective: We assessed the influence of race/ethnicity and provider communication on overweight and obese patients’ perceptions of the damage weight causes to their health. Methods: The study included 1071 overweight and obese patients who completed the 2002 Community Health Center (CHC) User survey. We used logistic regression analyses to examine determinants of patients’ perceptions of the impact of their weight on their health. Models were adjusted for covariates and weighting was used to account for the sampling design. Results: Forty-one percent of respondents were overweight and 59% were obese. Non-Hispanic Blacks and Hispanics were half as likely as non-Hispanic Whites to believe weight was damaging to their health while controlling for covariates. Overweight/obese CHC patients who were told they were overweight by healthcare providers were almost nine times more likely to perceive that weight was damaging to their health compared to those not told. Conclusions: We observed large racial/ethnic disparities in the perception that overweight is unhealthful but provider communication may be a powerful tool for helping patients understand that overweight is damaging to health. Practice implications: Given obesity is a national epidemic, further attention to the role of patient provider communication in illness is essential with important implications for both health professional training and health care provision. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient provider communication
KW - health effects
KW - obesity
KW - patients perceptions
KW - race
KW - overweight
KW - ethnicity
KW - 2009
KW - Client Attitudes
KW - Communication
KW - Health
KW - Obesity
KW - Racial and Ethnic Differences
KW - Ethnic Identity
KW - Overweight
KW - 2009
U1 - Sponsor: Maternal and Child Health Bureau, Leadership in Education for Adolescent Health project. Grant: 6T71-MC00009-15-01. Other Details: HRSA Grant. Recipients: No recipient indicated
U1 - Sponsor: Commonwealth Fund/Harvard University. Other Details: Fellowship in Minority Health Policy. Recipients: No recipient indicated
U1 - Sponsor: National Research Service Award, US. Grant: T32 HP10018. Recipients: No recipient indicated
DO - 10.1016/j.pec.2008.09.021
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03410-009&site=ehost-live&scope=site
UR - ndurant@peds.uab.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-04248-001
AN - 2009-04248-001
AU - Coffey, Rosanna M.
AU - Levit, Katharine R.
AU - Kassed, Cheryl A.
AU - McLellan, A. Thomas
AU - Chalk, Mady
AU - Brady, Thomas M.
AU - Vandivort-Warren, Rita
T1 - Evidence for substance abuse services and policy research: A systematic review of national databases.
JF - Evaluation Review
JO - Evaluation Review
JA - Eval Rev
Y1 - 2009/04//
VL - 33
IS - 2
SP - 103
EP - 137
CY - US
PB - Sage Publications
SN - 0193-841X
SN - 1552-3926
AD - Coffey, Rosanna M., Healthcare Business of Thomson Reuters, 4301 Connecticut Avenue, NW, Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2009-04248-001. PMID: 19126788 Other Journal Title: Evaluation Quarterly. Partial author list: First Author & Affiliation: Coffey, Rosanna M.; Healthcare Business of Thomson Reuters, Washington, DC, US. Release Date: 20091102. Correction Date: 20130422. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Addiction; Drug Rehabilitation; Policy Making. Minor Descriptor: Drug Abuse; Evidence Based Practice. Classification: Substance Abuse & Addiction (3233); Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 35. Issue Publication Date: Apr, 2009. Copyright Statement: Sage Publications. 2009.
AB - We reviewed 39 national government- and nongovernment-sponsored data sets related to substance addiction policy. These data sets describe patients with substance use disorders (SUDs), treatment providers and the services they offer, and/or expenditures on treatment. Findings indicate the availability of reliable data on the prevalence of SUD and the characteristics of specialty treatment facilities, but meager data on financing and services. Gaps in information might be filled through agency collaboration to redesign, coordinate, and augment existing substance abuse and general health surveys. Despite noted gaps, these data sets represent an unusually rich set of resources for health services and policy research. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - evidence based practice
KW - substance abuse
KW - addiction
KW - policy making
KW - drug rehabilitation
KW - 2009
KW - Addiction
KW - Drug Rehabilitation
KW - Policy Making
KW - Drug Abuse
KW - Evidence Based Practice
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 270-01-7088. Recipients: No recipient indicated
DO - 10.1177/0193841X08328126
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-04248-001&site=ehost-live&scope=site
UR - rosanna.coffey@thomsonreuters.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03051-004
AN - 2009-03051-004
AU - Mishra, Shiraz I.
AU - Lucksted, Alicia
AU - Gioia, Deborah
AU - Barnet, Beth
AU - Baquet, Claudia R.
T1 - Needs and preferences for receiving mental health information in an African American focus group sample.
JF - Community Mental Health Journal
JO - Community Mental Health Journal
JA - Community Ment Health J
Y1 - 2009/04//
VL - 45
IS - 2
SP - 117
EP - 126
CY - Germany
PB - Springer
SN - 0010-3853
SN - 1573-2789
AD - Mishra, Shiraz I., University of Maryland Statewide Health Network, University of Maryland School of Medicine, 401 W. Redwood Street, Suite #100, Baltimore, MD, US, 21201
N1 - Accession Number: 2009-03051-004. PMID: 18633704 Partial author list: First Author & Affiliation: Mishra, Shiraz I.; University of Maryland Statewide Health Network, University of Maryland School of Medicine, Baltimore, MD, US. Release Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Information; Mental Health Services. Minor Descriptor: Blacks; Health Care Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Interview; Focus Group; Qualitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Apr, 2009. Publication History: First Posted Date: Jul 17, 2008; Accepted Date: Jul 8, 2008; First Submitted Date: Jan 25, 2008. Copyright Statement: Springer Science+Business Media, LLC. 2008.
AB - The purpose of this study is to better understand the mental health/illness information and service delivery preferences among African American residents of Baltimore. We conducted four focus groups (n = 42) among African American adults currently unconnected with the mental health system. Participants expressed fear of stigma and perceptions of racism as major barriers to seeking information and/or services and discussed some normalizing strategies to address these barriers. African Americans harbor cultural and traditional beliefs regarding mental illness which could also act as barriers. Findings have implications for imparting acceptable and culturally sensitive mental health education and service delivery programs in community settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health information
KW - African American group
KW - service delivery preferences
KW - 2009
KW - Health Care Delivery
KW - Information
KW - Mental Health Services
KW - Blacks
KW - Health Care Services
KW - 2009
U1 - Sponsor: National Institutes of Health, National Center for Minority Health and Health Disparities, US. Grant: P60MD000532. Recipients: No recipient indicated
DO - 10.1007/s10597-008-9157-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03051-004&site=ehost-live&scope=site
UR - smishra@som.umaryland.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05093-003
AN - 2009-05093-003
AU - Keller, Dustin P.
AU - Schut, L. James A.
AU - Puddy, Richard W.
AU - Williams, Lygia
AU - Stephens, Robert L.
AU - McKeon, Richard
AU - Lubell, Keri
T1 - Tennessee Lives Count: Statewide gatekeeper training for youth suicide prevention.
T3 - Interventions for Suicidal Persons Across the Life Span
JF - Professional Psychology: Research and Practice
JO - Professional Psychology: Research and Practice
JA - Prof Psychol Res Pr
Y1 - 2009/04//
VL - 40
IS - 2
SP - 126
EP - 133
CY - US
PB - American Psychological Association
SN - 0735-7028
SN - 1939-1323
AD - Keller, Dustin P., Mental Health Association of Middle Tennessee, 2416 21st Avenue South, Suite 201, Nashville, TN, US, 37212
N1 - Accession Number: 2009-05093-003. Other Journal Title: Professional Psychology. Partial author list: First Author & Affiliation: Keller, Dustin P.; Mental Health Association of Middle Tennessee, Nashville, TN, US. Release Date: 20090413. Correction Date: 20140825. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Personnel Training; Suicide Prevention. Minor Descriptor: Child Welfare; Education; Juvenile Justice; Public Health Service Nurses. Classification: Professional Education & Training (3410). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Gatekeeper Efficacy scale; Lifelines Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2009. Publication History: Accepted Date: Oct 13, 2008; Revised Date: Sep 10, 2008; First Submitted Date: Jan 10, 2008. Copyright Statement: American Psychological Association. 2009.
AB - Youth suicide remains a significant public health problem in the United States. In 2004, the Garrett Lee Smith Memorial Act provided states and tribes with funding to implement and evaluate youth suicide prevention programs. The Tennessee Lives Count project was developed through a collaborative model at the state level and delivers an enhanced version of the Question, Persuade, Refer gatekeeper training program to individuals working with youth across the state. This article describes the development of the project and preliminary outcomes of 416 participants in child welfare, juvenile justice, health, and education systems at pretest, posttest, and 6-month follow-up. The findings suggest the training has an immediate and long-term impact on perceived knowledge of suicide prevention, self-efficacy, and attitudes about the inevitability of suicide. Policy and practice implications are presented. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide prevention
KW - gatekeeper training
KW - child welfare
KW - juvenile justice
KW - public health nursing
KW - education
KW - 2009
KW - Personnel Training
KW - Suicide Prevention
KW - Child Welfare
KW - Education
KW - Juvenile Justice
KW - Public Health Service Nurses
KW - 2009
DO - 10.1037/a0014889
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05093-003&site=ehost-live&scope=site
UR - dkeller@tspn.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02216-003
AN - 2009-02216-003
AU - Grzywacz, Joseph G.
AU - Alterman, Toni
AU - Muntaner, Carles
AU - Gabbard, Susan
AU - Nakamoto, Jorge
AU - Carroll, Daniel J.
T1 - Measuring job characteristics and mental health among Latino farmworkers: Results from cognitive testing.
JF - Journal of Immigrant and Minority Health
JO - Journal of Immigrant and Minority Health
Y1 - 2009/04//
VL - 11
IS - 2
SP - 131
EP - 138
CY - Germany
PB - Springer
SN - 1557-1912
SN - 1557-1920
AD - Grzywacz, Joseph G., Department of Family and Community Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, US, 27157-1084
N1 - Accession Number: 2009-02216-003. PMID: 18690536 Other Journal Title: Journal of Immigrant Health. Partial author list: First Author & Affiliation: Grzywacz, Joseph G.; Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, US. Release Date: 20091102. Correction Date: 20151026. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Measurement; Mental Health; Migrant Farm Workers; Occupational Stress; Test Validity. Minor Descriptor: Immigration; Working Conditions; Latinos/Latinas. Classification: Tests & Testing (2220); Personnel Attitudes & Job Satisfaction (3650). Population: Human (10). Location: US. Tests & Measures: K-6 Instrument; Migrant Farmworker Stress Inventory; Job Content Questionnaire DOI: 10.1037/t03609-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Apr, 2009.
AB - Background Few research instruments used in occupational stress research have been evaluated for acceptability and validity among immigrant Latino farmworkers. Methods Cognitive testing was completed with 40 migrant and seasonal farmworkers (21 women, 19 men) through two focus groups and 16 one-on-one interviews conducted in Texas and Florida. Participants responded to the K-6, a short form instrument designed to measure psychological distress, selected items from the Job Content Questionnaire (JCQ) and standard health items. Results The K-6 items were characterized as too long and using a higher ‘‘class’’ language than farmworkers use. Further, the cultural connotation of several items in the K-6 was viewed as inappropriate by farmworkers. Demand items from the JCQ were interpreted inconsistently, whereas decision latitude items were consistently understood but viewed as irrelevant to farmworkers. Conclusions The results highlight the difficulties involved in conducting research with immigrant farmworkers, and they suggest that researchers interested in studying antecedents and consequences of farmworker mental health need to select instruments cautiously. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - job characteristics
KW - mental health
KW - immigrant Latino farmworkers
KW - Job Content Questionnaire
KW - K-6 instrument
KW - validity
KW - acceptability
KW - occupational stress
KW - 2009
KW - Measurement
KW - Mental Health
KW - Migrant Farm Workers
KW - Occupational Stress
KW - Test Validity
KW - Immigration
KW - Working Conditions
KW - Latinos/Latinas
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health. Recipients: No recipient indicated
DO - 10.1007/s10903-008-9170-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02216-003&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-1512-4367
UR - ORCID: 0000-0002-2308-7781
UR - grywacz@wfubmc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02523-018
AN - 2009-02523-018
AU - Kroenke, Kurt
AU - Strine, Tara W.
AU - Spitzer, Robert L.
AU - Williams, Janet B. W.
AU - Berry, Joyce T.
AU - Mokdad, Ali H.
T1 - The PHQ-8 as a measure of current depression in the general population.
JF - Journal of Affective Disorders
JO - Journal of Affective Disorders
JA - J Affect Disord
Y1 - 2009/04//
VL - 114
IS - 1-3
SP - 163
EP - 173
CY - Netherlands
PB - Elsevier Science
SN - 0165-0327
SN - 1573-2517
AD - Kroenke, Kurt, Regenstrief Institute, RG-6 1050Wishard Blvd, Indianapolis, IN, US, 46202
N1 - Accession Number: 2009-02523-018. PMID: 18752852 Partial author list: First Author & Affiliation: Kroenke, Kurt; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, US. Release Date: 20090706. Correction Date: 20160407. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epidemiology; Health; Major Depression; Psychometrics; Quality of Life. Minor Descriptor: Diagnosis; Questionnaires. Classification: Clinical Psychological Testing (2224); Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Behavioral Risk Factor Surveillance System; Patient Health Questionnaire [Appended] DOI: 10.1037/t02598-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Apr, 2009. Publication History: First Posted Date: Aug 27, 2008; Accepted Date: Jun 30, 2008; Revised Date: Jun 29, 2008; First Submitted Date: Oct 24, 2007. Copyright Statement: All rights reserved. Elsevier B.V. 2008.
AB - Background: The eight-item Patient Health Questionnaire depression scale (PHQ-8) is established as a valid diagnostic and severity measure for depressive disorders in large clinical studies. Our objectives were to assess the PHQ-8 as a depression measure in a large, epidemiological population-based study, and to determine the comparability of depression as defined by the PHQ-8 diagnostic algorithm vs. a PHQ-8 cutpoint ≥10. Methods: Random-digit-dialed telephone survey of 198,678 participants in the 2006 Behavioral Risk Factor Surveillance Survey (BRFSS), a population-based survey in the United States. Current depression as defined by either the DSM-IV based diagnostic algorithm (i.e., major depressive or other depressive disorder) of the PHQ-8 or a PHQ-8 score ≥10; respondent sociodemographic characteristics; number of days of impairment in the past 30 days in multiple domains of health-related quality of life (HRQoL). Results: The prevalence of current depression was similar whether defined by the diagnostic algorithm or a PHQ-8 score ≥10 (9.1% vs. 8.6%). Depressed patients had substantially more days of impairment across multiple domains of HRQoL, and the impairment was nearly identical in depressed groups defined by either method. Of the 17,040 respondents with a PHQ-8 score ≥10, major depressive disorder was present in 49.7%, other depressive disorder in 23.9%, depressed mood or anhedonia in another 22.8%, and no evidence of depressive disorder or depressive symptoms in only 3.5%. Limitations: The PHQ-8 diagnostic algorithm rather than an independent structured psychiatric interview was used as the criterion standard. Conclusions: The PHQ-8 is a useful depression measure for population-based studies, and either its diagnostic algorithm or a cutpoint ≥10 can be used for defining current depression. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Patient Health Questionnaire
KW - depression
KW - epidemiology
KW - diagnosis
KW - psychometrics
KW - health-related quality of life
KW - 2009
KW - Epidemiology
KW - Health
KW - Major Depression
KW - Psychometrics
KW - Quality of Life
KW - Diagnosis
KW - Questionnaires
KW - 2009
DO - 10.1016/j.jad.2008.06.026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02523-018&site=ehost-live&scope=site
UR - kkroenke@regenstrief.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06071-005
AN - 2009-06071-005
AU - Squillace, Marie R.
AU - Remsburg, Robin E.
AU - Harris-Kojetin, Lauren D.
AU - Bercovitz, Anita
AU - Rosenoff, Emily
AU - Han, Beth
T1 - The National Nursing Assistant Survey: Improving the evidence base for policy initiatives to strengthen the certified nursing assistant workforce.
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2009/04//
VL - 49
IS - 2
SP - 185
EP - 197
CY - United Kingdom
PB - Oxford University Press
SN - 0016-9013
SN - 1758-5341
AD - Squillace, Marie R., Aging and Long-Term Care Policy, Office of the Secretary/Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services, 200 Independence Avenue, S.W., Room 424.E20, Washington, DC, US, 20201
N1 - Accession Number: 2009-06071-005. PMID: 19363014 Partial author list: First Author & Affiliation: Squillace, Marie R.; Aging and Long-Term Care Policy, Office of the Secretary/Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services, Washington, DC, US. Other Publishers: Gerontological Society of America. Release Date: 20100111. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Nursing Homes; Surveys; Health Personnel. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Apr, 2009. Publication History: First Posted Date: Apr 1, 2009; Accepted Date: Apr 9, 2008; Revised Date: Jan 8, 2008.
AB - Purpose: This study introduces the first National Nursing Assistant Survey (NNAS), a major advance in the data available about certified nursing assistants (CNAs) and a rich resource for evidence-based policy, practice, and applied research initiatives. We highlight potential uses of this new survey using select population estimates as examples of how the NNAS can be used to inform new policy directions. Design and Methods: The NNAS is a nationally representative survey of 3,017 CNAs working in nursing homes, who were interviewed by phone in 2004-2005. Key survey components are recruitment; education; training and licensure; job history; family life; management and supervision; client relations; organizational commitment and job satisfaction; workplace environment; work-related injuries; and demographics. Results: One in three CNAs received some kind of means-tested public assistance. More than half of CNAs incurred at least 1 work-related injury within the past year and almost one quarter were unable to work for at least 1 day due to the injury. Forty-two percent of uninsured CNAs cite not participating in their employer-sponsored insurance plan because they could not afford the plan. Years of experience do not translate into higher wages; CNAs with 10 or more years of experience averaged just $2/hr more than aides who started working in the field less than 1 year ago. Implications: This survey can be used to understand CNA workforce issues and challenges and to plan for sustainable solutions to stabilize this workforce. The NNAS can be linked to other existing data sets to examine more comprehensive and complex relationships among CNA, facility, resident, and community characteristics, thereby expanding its usefulness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nursing assistants
KW - National Nursing Assistant Survey
KW - 2009
KW - Nursing Homes
KW - Surveys
KW - Health Personnel
KW - 2009
DO - 10.1093/geront/gnp024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06071-005&site=ehost-live&scope=site
UR - marie.squillace@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02978-006
AN - 2009-02978-006
AU - Kang, T. S.
AU - Woo, S. W.
AU - Park, H. J.
AU - Lee, Y.
AU - Roh, J.
T1 - Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups.
JF - Journal of Clinical Pharmacy and Therapeutics
JO - Journal of Clinical Pharmacy and Therapeutics
JA - J Clin Pharm Ther
Y1 - 2009/04//
VL - 34
IS - 2
SP - 225
EP - 230
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0269-4727
SN - 1365-2710
AD - Roh, J., Department of Obstetrics & Gynecology, Hanyang University Medical Center, Haengdang-dong, Seongdong-gu, Seoul, Republic of Korea, 133-792
N1 - Accession Number: 2009-02978-006. PMID: 19250143 Partial author list: First Author & Affiliation: Kang, T. S.; Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea. Other Publishers: Blackwell Publishing. Release Date: 20091130. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Enzymes; Ethanol; Genetics; Metabolism. Minor Descriptor: Korean Cultural Groups; Polymorphism; Racial and Ethnic Groups. Classification: Genetics (2510). Population: Human (10). Location: Korea. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 2009. Publication History: Accepted Date: Sep 11, 2008; First Submitted Date: Aug 19, 2008. Copyright Statement: The Authors. 2008.
AB - Background and objectives: Recent studies of the genetics of alcoholism have considered genetic factors in alcohol metabolism and have identified functional polymorphisms in genes encoding enzymes involved in ethanol metabolism. The aim of this study was to estimate the genotype and allele frequencies of polymorphisms of three major ethanol-metabolizing enzymes (ADH2, ALDH2 and CYP2E1) in Koreans and to compare them with those of other ethnic groups. Methods: We chose three polymorphisms, ADH2 (2), ALDH2 (2) and CYP2E1 (c2), which are most likely to affect alcohol metabolism. To evaluate the allele frequencies of these single-nucleotide polymorphisms, 342 healthy Korean volunteers were recruited. Each genotype was determined by the TaqMan or SNaPshot method with genomic DNA extracted from peripheral leucocytes. We compared these allele frequencies with those of other ethnic groups registered on the International HapMap database. Results and discussion: The allele frequencies in Koreans were 80·3% for the ADH2 (2), 13·9% for ALDH2 (2), and 20·9% for CYP2E1 (c2). Other Asians, including Japanese and Chinese populations, show similar frequencies (Japanese, 73·9%, 22·7%, and 20·5% respectively and Chinese, 76·7%, 15·6%, and 28·9% respectively), whereas African and European groups have quite different frequencies (Europeans, 0%, 0%, and 5·1% respectively and African, 0%, 0%, and 0% respectively). Conclusion: Our current observations provide data on the prevalence of polymorphisms of ethanol-metabolizing enzymes, which should be useful in assessing the comparative susceptibility of different populations to diseases related to ethanol consumption. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genetic polymorphisms
KW - ethanol-metabolizing enzymes
KW - genes
KW - alcohol metabolism
KW - ethnic groups
KW - Koreans
KW - 2009
KW - Enzymes
KW - Ethanol
KW - Genetics
KW - Metabolism
KW - Korean Cultural Groups
KW - Polymorphism
KW - Racial and Ethnic Groups
KW - 2009
U1 - Sponsor: Korea Food and Drug Administration, Korea. Grant: 07151KFDA675. Recipients: No recipient indicated
DO - 10.1111/j.1365-2710.2008.00986.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02978-006&site=ehost-live&scope=site
UR - rohjaesook@hanyang.ac.kr
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05794-005
AN - 2009-05794-005
AU - Drukker, Marjan
AU - Feron, Frans J. M.
AU - Mengelers, Ron
AU - Van Os, Jim
T1 - Neighborhood socioeconomic and social factors and school achievement in boys and girls.
JF - The Journal of Early Adolescence
JO - The Journal of Early Adolescence
JA - J Early Adolesc
Y1 - 2009/04//
VL - 29
IS - 2
SP - 285
EP - 306
CY - US
PB - Sage Publications
SN - 0272-4316
SN - 1552-5449
N1 - Accession Number: 2009-05794-005. Partial author list: First Author & Affiliation: Drukker, Marjan; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands. Release Date: 20090720. Correction Date: 20121008. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Academic Achievement; Human Sex Differences; Neighborhoods; Social Capital; Socioeconomic Status. Minor Descriptor: Adolescent Development; Social Issues. Classification: Psychosocial & Personality Development (2840); Academic Learning & Achievement (3550). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Nijmegen Parental Stress Index Short Version. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 22. Issue Publication Date: Apr, 2009.
AB - Previous work has shown that school achievement is lower in children living in poor neighborhoods. In this study, the authors hypothesized a role of neighborhood social capital. Data on 11-year-olds were obtained from the baseline measurements of a family cohort study (n = 328). The data had a cross-level structure: neighborhood level, school level, and individual level. After including individual-level confounders, neighborhood socioeconomic disadvantage and social cohesion were not associated with school achievement in boys or girls. However, lower levels of neighborhood informal social control were associated with lower school achievement scores in boys only. In boys, a wider social environment that contributes to obedience to norms and values may be conducive to superior educational achievement. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - school achievement
KW - neighborhoods
KW - social capital
KW - adolescence
KW - gender differences
KW - socioeconomic status
KW - social factors
KW - 2009
KW - Academic Achievement
KW - Human Sex Differences
KW - Neighborhoods
KW - Social Capital
KW - Socioeconomic Status
KW - Adolescent Development
KW - Social Issues
KW - 2009
DO - 10.1177/0272431608320124
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05794-005&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-04906-007
AN - 2009-04906-007
AU - Zhang, D.
AU - Cheng, L.
AU - Qian, Y.
AU - Alliey-Rodriguez, N.
AU - Kelsoe, J. R.
AU - Greenwood, T.
AU - Nievergelt, C.
AU - Barrett, T. B.
AU - McKinney, R.
AU - Schork, N.
AU - Smith, E. N.
AU - Bloss, C.
AU - Nurnberger, J.
AU - Edenberg, H. J.
AU - Foroud, T.
AU - Sheftner, W.
AU - Lawson, W. B.
AU - Nwulia, E. A.
AU - Hipolito, M.
AU - Coryell, W.
AU - Rice, J.
AU - Byerley, W.
AU - McMahon, F.
AU - Schulze, T. G.
AU - Berrettini, W.
AU - Potash, J. B.
AU - Belmonte, P. L.
AU - Zandi, P. P.
AU - McInnis, M. G.
AU - Zöllner, S.
AU - Craig, D.
AU - Szelinger, S.
AU - Koller, D.
AU - Christian, S. L.
AU - Liu, C.
AU - Gershon, E. S.
T1 - Singleton deletions throughout the genome increase risk of bipolar disorder.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2009/04//
VL - 14
IS - 4
SP - 376
EP - 380
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Gershon, E. S., Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 South Maryland Avenue, MC3077, Chicago, IL, US, 60637
N1 - Accession Number: 2009-04906-007. PMID: 19114987 Partial author list: First Author & Affiliation: Zhang, D.; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, US. Release Date: 20090810. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Bipolar Disorder; Genome; Polymorphism; Risk Factors. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Diagnostic Interview for Genetic Studies. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Tables and Figures Internet. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2009.
AB - An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with micro duplication and micro deletion. Here, we present a genome-wide copy number variant (CNV) survey of 1,001 cases and 1,034 controls using the Affymetrix single nucleotide polymorphism (SNP) 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only once in the dataset) more than 100 kb in length are present in 16.2% of BD cases in contrast to 12.3% of controls (permutation P = 0.007). This effect was more pronounced for age at onset of mania ≤18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genome
KW - copy number variants
KW - singleton deletions
KW - risk factors
KW - bipolar disorder
KW - 2009
KW - Bipolar Disorder
KW - Genome
KW - Polymorphism
KW - Risk Factors
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: 1R01MH081804-01. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Eklund Family. Recipients: No recipient indicated
U1 - Sponsor: Geraldi Norton Foundation. Recipients: No recipient indicated
DO - 10.1038/mp.2008.144
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-04906-007&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR - ORCID: 0000-0002-9324-7090
UR - ORCID: 0000-0001-5766-8923
UR - ORCID: 0000-0002-6080-6503
UR -
UR - egershon@yoda.bsd.uchicago.edu
UR - cliu@yoda.bsd.uchicago.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06947-003
AN - 2009-06947-003
AU - Hennessy, Kevin D.
AU - Chambers, David A.
T1 - Delivery of excellent mental health care and acceleration of research: Federal activities since the President’s Commission Report.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/04//
VL - 60
IS - 4
SP - 433
EP - 438
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Hennessy, Kevin D., Office of Policy, Planning, and Budget, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Rd., Room 8-1017, Rockville, MD, US, 20857
N1 - Accession Number: 2009-06947-003. PMID: 19339316 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Hennessy, Kevin D.; Office of Policy, Planning, and Budget, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20090727. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communities; Experimentation; Government; Health Care Delivery; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Apr, 2009.
AB - The report of the President’s New Freedom Commission set forth six goals and related recommendations to enable adults with serious mental illness and children with serious emotional disturbance to participate fully in their communities. This article focuses on goal 5-'Excellent mental health care is delivered and research is accelerated'-and its four related recommendations. The authors describe federal government activities undertaken since the report was released. To accelerate research, the National Institute of Mental Health (NIMH) has launched initiatives to find ways to interrupt the progress of schizophrenia and to identify interventions for combat veterans with mental health problems. To advance evidence-based practices, the Substance Abuse and Mental Health Services Administration (SAMHSA) has expanded and transformed its National Registry of Evidence-Based Programs and Practices and NIMH has launched a major research initiative to build the knowledge base for dissemination and implementation. To improve and expand the workforce, SAMHSA has published an action plan for workforce development and NIMH has established grants to develop curricula to integrate training in evidence-based practices into clinical training programs. To develop knowledge in understudied areas, NIMH has funded studies to reduce and eliminate disparities and SAMHSA has supported efforts to improve delivery of trauma-informed services, such as the National Child Traumatic Stress Network. Continued advancement in goal 5 areas calls for commitment to working across agency and organizational boundaries to ensure more rapid and widespread dissemination and implementation of research and policies and for further development of ways to promote the participation of all stakeholders. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health care delivery
KW - mental health care
KW - research acceleration
KW - federal activities
KW - communities
KW - recommendations
KW - 2009
KW - Communities
KW - Experimentation
KW - Government
KW - Health Care Delivery
KW - Mental Health Services
KW - 2009
DO - 10.1176/appi.ps.60.4.433
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06947-003&site=ehost-live&scope=site
UR - kevin.hennessy@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-04069-001
AN - 2009-04069-001
AU - Noble, Robert B.
AU - Bailer, A. John
AU - Park, Robert
T1 - Model-averaged benchmark concentration estimates for continuous response data arising from epidemiological studies.
JF - Risk Analysis
JO - Risk Analysis
JA - Risk Anal
Y1 - 2009/04//
VL - 29
IS - 4
SP - 558
EP - 564
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0272-4332
SN - 1539-6924
AD - Noble, Robert B., Department of Mathematics & Statistics, Miami University, Oxford, OH, US, 45056
N1 - Accession Number: 2009-04069-001. PMID: 19144062 Partial author list: First Author & Affiliation: Noble, Robert B.; Department of Mathematics & Statistics, Miami University, Oxford, OH, US. Other Publishers: Blackwell Publishing. Release Date: 20090518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Noble, Robert B. Major Descriptor: Concentration; Epidemiology; Hazardous Materials; Occupational Exposure. Minor Descriptor: Lung. Classification: Environmental Issues & Attitudes (4070); Working Conditions & Industrial Safety (3670). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Apr, 2009.
AB - Worker populations often provide data on adverse responses associated with exposure to potential hazards. The relationship between hazard exposure levels and adverse response can be modeled and then inverted to estimate the exposure associated with some specified response level. One concern is that this endpoint may be sensitive to the concentration metric and other variables included in the model. Further, it may be that the models yielding different risk endpoints are all providing relatively similar fits. We focus on evaluating the impact of exposure on a continuous response by constructing a model-averaged benchmark concentration from a weighted average of model-specific benchmark concentrations. A method for combining the estimates based on different models is applied to lung function in a cohort of miners exposed to coal dust. In this analysis, we see that a small number of the thousands of models considered survive a filtering criterion for use in averaging. Even after filtering, the models considered yield benchmark concentrations that differ by a factor of 2 to 9 depending on the concentration metric and covariates. The model-average BMC captures this uncertainty, and provides a useful strategy for addressing model uncertainty. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epidemiology
KW - hazards
KW - miners
KW - coal dust
KW - concentration estimates
KW - lung function
KW - 2009
KW - Concentration
KW - Epidemiology
KW - Hazardous Materials
KW - Occupational Exposure
KW - Lung
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health. Grant: 211-2005-M-13470. Recipients: Noble, Robert B.
DO - 10.1111/j.1539-6924.2008.01178.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-04069-001&site=ehost-live&scope=site
UR - noblerb@muohio.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06574-001
AN - 2009-06574-001
AU - Lathers, Claire M.
AU - Schraeder, Paul L.
T1 - Verbal autopsies and SUDEP.
JF - Epilepsy & Behavior
JO - Epilepsy & Behavior
JA - Epilepsy Behav
Y1 - 2009/04//
VL - 14
IS - 4
SP - 573
EP - 576
CY - Netherlands
PB - Elsevier Science
SN - 1525-5050
AD - Lathers, Claire M., 115 South Manning Boulevard, Albany, NY, US, 12203
N1 - Accession Number: 2009-06574-001. PMID: 19435572 Partial author list: First Author & Affiliation: Lathers, Claire M.; Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, US. Release Date: 20090720. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Autopsy; Death and Dying; Developed Countries; Epilepsy; Medical Records. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). References Available: Y. Page Count: 4. Issue Publication Date: Apr, 2009.
AB - There is a problem in defining the occurrence of sudden unexplained death in persons with epilepsy (SUDEP). The diagnosis of SUDEP in the United States is under-used as many do not use the term on the death certificate. SUDEP is found to be more prevalent worldwide than assumed. However, data for developing countries, which are even more limited than those for Europe and North America, and do not depend on the use of autopsies, indicate that SUDEP is an underreported cause of death in persons with epilepsy. To glean information about the circumstances of the 'sudden death event' in epilepsy, the verbal autopsy may be used, that is, talking with family members and/or close friends of the patient who has died unexpectedly. In contrast to developing countries, where verbal autopsy may be the only means of establishing a possible or probable cause of death, the technique of verbal autopsy may have a different use in more affluent countries. It is a defined technique to help clarify questions not answered by the standard methods of coroner and postmortem reports and not available in medical records. The purpose of verbal autopsy can be multifaceted. When used in conjunction with postmortem autopsy data on persons who die from SUDEP, it can focus on retrospective data that provide additional help in identifying more accurately the cause of death and in conducting retrospective analysis of these postmortem examinations. The value of these cumulative data from all sources is that they provide information for future preventative policy. In circumstances where postmortem information is not or cannot be collected, verbal autopsies offer a method to find information regarding the cause of death, whether conducted in developing countries or in developed countries. In either case, the worldwide database on persons with epilepsy who die suddenly and unexpectedly will gain information that will help in determining the prevalence of SUDEP and contribute to the quest for identification of preventive interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - verbal autopsies
KW - sudden unexplained death in epilepsy
KW - death certificate
KW - developing countries
KW - 2009
KW - Autopsy
KW - Death and Dying
KW - Developed Countries
KW - Epilepsy
KW - Medical Records
KW - 2009
DO - 10.1016/j.yebeh.2009.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06574-001&site=ehost-live&scope=site
UR - lathers@attglobal.net
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03829-007
AN - 2009-03829-007
AU - Becker, Susan M.
T1 - Psychosocial care for women survivors of the tsunami disaster in India.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/04//
VL - 99
IS - 4
SP - 654
EP - 658
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Becker, Susan M., Department of Health and Human Services, HRSA, 5600 Fisher’s Lane, Rockville, MD, US, 20057
N1 - Accession Number: 2009-03829-007. PMID: 19150896 Partial author list: First Author & Affiliation: Becker, Susan M.; College of Public Health, University of South Florida, Tampa, FL, US. Release Date: 20090518. Correction Date: 20120514. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Community Mental Health Services; Natural Disasters; Psychosocial Factors; Survivors; Treatment Effectiveness Evaluation. Minor Descriptor: Human Females. Classification: Health & Mental Health Services (3370). Population: Human (10); Female (40). Location: India. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Self-Reporting Questionnaire; Impact of Event Scale DOI: 10.1037/t00303-000. Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 5. Issue Publication Date: Apr, 2009.
AB - Objectives: I investigated the effectiveness of Psychosocial Care, a community-based mental health initiative for survivors of the 2004 tsunami disaster in India. Methods: Mental health teams from the National Institute of Mental Health and Neurosciences (NIMHANS) in India implemented a train-the-trainer model of psychosocial care in one of the worst tsunami-affected areas of south India. Three months of psychosocial care was provided for an intervention group of women, but not for a control group recruited from an exposed neighboring village. Impact of Event Scale (IES) scores—both total scores and scores for subscales on hypervigilance, avoidance, and intrusion—were compiled for both the intervention and control groups and used as outcome measures. Results: For the intervention group, posttest total IES and subscale scores were significantly lower than pretest scores (P < .001), indicating improvement in symptoms. Posttest total IES and subscale scores were significantly lower for the intervention group than for the control group (P < .001). Conclusions: Psychosocial care is an effective mental health strategy for women survivors of disasters and should be an integral component of disaster response in resource-poor countries. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - women survivors
KW - psychosocial care
KW - community-based mental health initiative
KW - tsunami disaster
KW - intervention effectiveness
KW - 2009
KW - Community Mental Health Services
KW - Natural Disasters
KW - Psychosocial Factors
KW - Survivors
KW - Treatment Effectiveness Evaluation
KW - Human Females
KW - 2009
U1 - Sponsor: Naval Health Research Center, US. Grant: N66001-03-D-2500 DO 0013. Recipients: No recipient indicated
U1 - Sponsor: Fulbright Foundation. Grant: 2004/VL/32. Recipients: No recipient indicated
U1 - Sponsor: Ford Foundation. Recipients: No recipient indicated
DO - 10.2105/AJPH.2008.146571
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03829-007&site=ehost-live&scope=site
UR - sbecker@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-01021-029
AN - 2010-01021-029
AU - Barton, Mary B.
T1 - Screening and treatment for major depressive disorder in children and adolescents: US Preventive Services Task Force recommendation statement.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/04//
VL - 123
IS - 4
SP - 1223
EP - 1228
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Barton, Mary B., Agency for Healthcare Research and Quality, Center for Primary Care, Prevention, and Clinical Practice, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2010-01021-029. Partial author list: First Author & Affiliation: Barton, Mary B.; Agency for Healthcare Research and Quality, Center for Primary Care, Prevention, and Clinical Practice, Rockville, MD, US. Institutional Authors: US Preventive Services Task Force. Release Date: 20101004. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Screening; Major Depression; Mental Health Services; Preventive Medicine. Minor Descriptor: Pediatrics; Psychotherapy; Treatment. Classification: Affective Disorders (3211); Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adolescence (13-17 yrs) (200). Methodology: Literature Review. References Available: Y. Page Count: 6. Issue Publication Date: Apr, 2009. Publication History: Accepted Date: Aug 7, 2008.
AB - Descriptions: This is an update of the 2002 US Preventive Services Task Force recommendation on screening for child and adolescent major depressive disorder. Methods: The US Preventive Services Task Force weighed the benefits and harms of screening and treatment for major depressive disorder in children and adolescents, incorporating new evidence addressing gaps in the 2002 recommendation statement. Evidence examined included the benefits and harms of screening, the accuracy of primary care–feasible screening tests, and the benefits and risks of treating depression by using psychotherapy and/or medications in patients aged 7 to 18 years. Recommendations: Screen adolescents (12–18 years of age) for major depressive disorder when systems are in place to ensure accurate diagnosis, psychotherapy (cognitive- behavioral or interpersonal), and follow-up (B recommendation). Evidence is insufficient to warrant a recommendation to screen children (7–11 years of age) for major depressive disorder (I statement). (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health screening
KW - treatment
KW - major depressive disorder
KW - children
KW - adolescents
KW - United States
KW - preventive services task force
KW - psychotherapy
KW - 2009
KW - Health Screening
KW - Major Depression
KW - Mental Health Services
KW - Preventive Medicine
KW - Pediatrics
KW - Psychotherapy
KW - Treatment
KW - 2009
DO - 10.1542/peds.2008-2381
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-01021-029&site=ehost-live&scope=site
UR - mary.barton@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Brenner, Michaela
AU - Coelho, Sergio G.
AU - Beer, Janusz Z.
AU - Miller, Sharon A.
AU - Wolber, Rainer
AU - Smuda, Christoph
AU - Hearing, Vincent J.
T1 - Long-Lasting Molecular Changes in Human Skin after Repetitive In Situ UV Irradiation.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2009/04/02/Apr2009 Supplement 1
VL - 129
M3 - Article
SP - 1002
EP - 1011
SN - 0022202X
AB - It is known that UV modulates the expression of paracrine factors that regulate melanocyte function in the skin. We investigated the consequences of repetitive UV exposure of human skin in biopsies of 10 subjects with phototypes 2–3.5 taken 1–4 years later. The expression of melanogenic factors (TYR, MART1, MITF), growth factors/receptors (SCF/KIT, bFGF/FGFR1, ET1/EDNRB, HGF, GM-CSF), adhesion molecules (β-catenin, E-cadherin, N-cadherin), cell cycle proteins (PCNA, cyclins D1, E2) as well as Bcl-2, DKK1, and DKK3, were analyzed by immunohistochemistry. Most of those markers showed no detectable changes at 1 year after the repetitive UV irradiation. Although increased expression of EDNRB protein was detected in 3 of 10 UV-irradiated subjects, there was no detectable change in the expression of ET1 protein or in EDNRB mRNA levels. In summary, only the expression of TYR, MART1, and/or EDNRB, and only in some subjects, was elevated at 1 year after UV irradiation. Thus the long-term effects of repetitive UV irradiation on human skin did not lead to significant changes in skin morphology and there is considerable subject-to-subject variation in responses. The possibility that changes in the expression and function of EDNRB triggers downstream activation of abnormal melanocyte proliferation and differentiation deserves further investigation.Journal of Investigative Dermatology (2009) 129, 1002–1011; doi:10.1038/jid.2008.325; published online 23 October 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SKIN
KW - RESEARCH
KW - ULTRAVIOLET radiation
KW - MELANOGENESIS
KW - PARACRINE mechanisms
KW - MELANOCYTES
KW - CELL adhesion molecules
KW - CELL proliferation
KW - IMMUNOHISTOCHEMISTRY
N1 - Accession Number: 37158347; Brenner, Michaela 1 Coelho, Sergio G. 2 Beer, Janusz Z. 3 Miller, Sharon A. 3 Wolber, Rainer 4 Smuda, Christoph 4 Hearing, Vincent J. 2; Email Address: hearingv@nih.gov; Affiliation: 1: Department of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany 2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 3: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA 4: R&D, Skin Research, Beiersdorf AG, Hamburg, Germany; Source Info: Apr2009 Supplement 1, Vol. 129, p1002; Subject Term: SKIN; Subject Term: RESEARCH; Subject Term: ULTRAVIOLET radiation; Subject Term: MELANOGENESIS; Subject Term: PARACRINE mechanisms; Subject Term: MELANOCYTES; Subject Term: CELL adhesion molecules; Subject Term: CELL proliferation; Subject Term: IMMUNOHISTOCHEMISTRY; Number of Pages: 10p; Illustrations: 9 Color Photographs, 3 Charts; Document Type: Article
L3 - 10.1038/jid.2008.325
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37158347&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Trehy, Michael L.
AU - Reepmeyer, John C.
AU - Kolinski, Richard E.
AU - Westenberger, Benjamin J.
AU - Buhse, Lucinda F.
T1 - Analysis of heparin sodium by SAX/HPLC for contaminants and impurities
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2009/04/05/
VL - 49
IS - 3
M3 - Article
SP - 670
EP - 673
SN - 07317085
AB - Abstract: A chromatographic method was developed for the detection and quantification of the contaminant oversulfated chondroitin sulfate (OSCS) and the impurity dermatan sulfate in heparin active pharmaceutical ingredient (API). The HPLC analysis of heparin is carried out using a polymer-based strong anion exchange (SAX) column with gradient elution from 0.125M sodium chloride to 2.5M sodium chloride buffered mobile phase. The limit of detection (LOD) and limit of quantitation (LOQ) for the contaminant OSCS in heparin were determined to be 0.03% and 0.1%, respectively. The LOD and LOQ for dermatan sulfate, an impurity in heparin sulfate, were determined to be 0.1% and 0.8%, respectively. This manuscript is not a policy document and is not intended to replace either of the methods (capillary electrophoresis and NMR) currently required by the FDA. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPARIN
KW - CONTAMINATION (Technology)
KW - HIGH performance liquid chromatography
KW - CHONDROITIN sulfates
KW - DERMATAN sulfate
KW - SODIUM
KW - GLYCOSAMINOGLYCANS
KW - NUCLEAR magnetic resonance
KW - Dermatan sulfate
KW - Glycosaminoglycan
KW - Heparin
KW - HPLC
KW - Oversulfated chondroitin sulfate
N1 - Accession Number: 36898706; Trehy, Michael L.; Email Address: michael.trehy@fda.hhs.gov Reepmeyer, John C. 1 Kolinski, Richard E. 1 Westenberger, Benjamin J. 1 Buhse, Lucinda F. 1; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, Saint Louis, MO 63101, USA; Source Info: Apr2009, Vol. 49 Issue 3, p670; Subject Term: HEPARIN; Subject Term: CONTAMINATION (Technology); Subject Term: HIGH performance liquid chromatography; Subject Term: CHONDROITIN sulfates; Subject Term: DERMATAN sulfate; Subject Term: SODIUM; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: NUCLEAR magnetic resonance; Author-Supplied Keyword: Dermatan sulfate; Author-Supplied Keyword: Glycosaminoglycan; Author-Supplied Keyword: Heparin; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Oversulfated chondroitin sulfate; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jpba.2008.12.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36898706&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bonhoeffer, Jan
AU - Bentsi-Enchill, Adwoa
AU - Chen, Robert T.
AU - Fisher, Margaret C.
AU - Gold, Michael S.
AU - Hartman, Katharina
AU - Heininger, Ulrich
AU - Hoet, Bernard
AU - Jefferson, Thomas
AU - Khuri-Bulos, Najwa
AU - Kohl, Katrin S.
AU - Marcy, S. Michael
AU - Nalin, David
AU - Pless, Robert
AU - Sanabria-Rojas, Hernan
AU - Sleeman, Karen
AU - Wise, Robert
T1 - Guidelines for collection, analysis and presentation of vaccine safety data in pre- and post-licensure clinical studies
JO - Vaccine
JF - Vaccine
Y1 - 2009/04/06/
VL - 27
IS - 16
M3 - Article
SP - 2282
EP - 2288
SN - 0264410X
KW - Guidelines
KW - Immunization
KW - Safety
KW - Vaccine
N1 - Accession Number: 36972609; Bonhoeffer, Jan 1; Email Address: secretariat@brightoncollaboration.org; Bentsi-Enchill, Adwoa 2; Chen, Robert T. 3; Fisher, Margaret C. 4; Gold, Michael S. 5; Hartman, Katharina 6; Heininger, Ulrich 1; Hoet, Bernard 7; Jefferson, Thomas 8; Khuri-Bulos, Najwa 9; Kohl, Katrin S. 3; Marcy, S. Michael 10; Nalin, David 11; Pless, Robert 12; Sanabria-Rojas, Hernan 13; Sleeman, Karen 14; Wise, Robert 15; Affiliations: 1: University Children's Hospital Basel, Basel, Switzerland; 2: World Health Organization, Geneva, Switzerland; 3: Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: The Children's Hospital at Monmouth Medical Center, Long Branch, NJ, USA; 5: South Australian Immunisation Coordination Unit, Adelaide, Australia; 6: Berna Biotech AG, Bern, Switzerland; 7: GlaxoSmithKline Biologicals, Rixensart, Belgium; 8: Cochrane Vaccines Field and Health Reviews Ltd., Rome, Italy; 9: Jordan University Hospital, Amman, Jordan; 10: University of Southern California, Los Angeles, CA, USA; 11: Consultant in Vaccinology, PE, USA; 12: Centre for Infectious Disease Prevention and Control, Ottawa, Canada; 13: Instituto Nacional de Salud, Lima, Peru; 14: John Radcliffe Hospital, Oxford, United Kingdom; 15: Food and Drug Administration, Rockville, MD, USA; Issue Info: Apr2009, Vol. 27 Issue 16, p2282; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Vaccine; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.11.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36972609&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Bonhoeffer, Jan
AU - Bentsi-Enchill, Adwoa
AU - Chen, Robert T.
AU - Fisher, Margaret C.
AU - Gold, Michael S.
AU - Hartman, Katharina
AU - Heininger, Ulrich
AU - Hoet, Bernard
AU - Jefferson, Thomas
AU - Khuri-Bulos, Najwa
AU - Kohl, Katrin
AU - Marcy, S. Michael
AU - Nalin, David
AU - Pless, Robert
AU - Sanabria-Rojas, Hernan
AU - Sleeman, Karen
AU - Wise, Robert
T1 - Guidelines for collection, analysis and presentation of vaccine safety data in surveillance systems
JO - Vaccine
JF - Vaccine
Y1 - 2009/04/06/
VL - 27
IS - 16
M3 - Article
SP - 2289
EP - 2297
SN - 0264410X
KW - Guidelines
KW - Immunization
KW - Safety
KW - Vaccine
N1 - Accession Number: 36972610; Bonhoeffer, Jan 1; Email Address: secretariat@brightoncollaboration.org; Bentsi-Enchill, Adwoa 2; Chen, Robert T. 3; Fisher, Margaret C. 4; Gold, Michael S. 5; Hartman, Katharina 6; Heininger, Ulrich 1; Hoet, Bernard 7; Jefferson, Thomas 8; Khuri-Bulos, Najwa 9; Kohl, Katrin 3; Marcy, S. Michael 10; Nalin, David 11; Pless, Robert 12; Sanabria-Rojas, Hernan 13; Sleeman, Karen 14; Wise, Robert 15; Affiliations: 1: University Children's Hospital Basel, Basel,Switzerland; 2: World Health Organization, Geneva, Switzerland; 3: Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: The Children's Hospital at Monmouth Medical Center, Long Branch, NJ, USA; 5: South Australian Immunisation Coordination Unit, Adelaide, Australia; 6: Berna Biotech AG, Bern, Switzerland; 7: GlaxoSmithKline Biologicals, Rixensart, Belgium; 8: Cochrane Vaccines Field and Health Reviews Ltd., Rome, Italy; 9: Jordan University Hospital, Amman, Jordan; 10: University of Southern California, Los Angeles, CA, USA; 11: Consultant in Vaccinology, PE, USA; 12: Centre for Infectious Disease Prevention and Control, Ottawa, Canada; 13: Instituto Nacional de Salud, Lima, Peru; 14: John Radcliffe Hospital, Oxford, United Kingdom; 15: Food and Drug Administration, MD, USA; Issue Info: Apr2009, Vol. 27 Issue 16, p2289; Author-Supplied Keyword: Guidelines; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Safety; Author-Supplied Keyword: Vaccine; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2008.11.035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36972610&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thompson, Karol L.
AU - Pine, P. Scott
T1 - Comparison of the diagnostic performance of human whole genome microarrays using mixed-tissue RNA reference samples
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/04/10/
VL - 186
IS - 1
M3 - Article
SP - 58
EP - 61
SN - 03784274
AB - Abstract: Universal approaches for assessing the diagnostic performance of microarray assays are essential for the application of microarray technology to clinical and regulatory settings. Reference systems for diagnostic assays in laboratory medicine typically involve the utilization of reference samples, metrics, and reference datasets to ensure that measurements are comparable and true. For microarray performance evaluation and process improvement, reference samples can be composed of mixes of different tissue or cell line RNAs that contain tissue-selective analytes at defined target ratios. The diagnostic accuracy of detected changes in expression, measured as the area under the curve from receiver-operating characteristic plots, can provide a single commutable value for comparing assay specificity and sensitivity. Examples of applying this method for assessing overall performance are provided using public datasets generated on five commercial human whole genome microarray platforms for the MicroArray Quality Control project, a community-wide effort to address issues surrounding microarray data reliability. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA
KW - DNA microarrays
KW - Clinical pathology
KW - Clinical medicine
KW - Medical care
KW - Gene expression
KW - Performance evaluation
KW - Metrics
KW - Microarray
KW - Standards
N1 - Accession Number: 36898909; Thompson, Karol L.; Email Address: karol.thompson@fda.hhs.gov; Pine, P. Scott 1; Affiliations: 1: Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA; Issue Info: Apr2009, Vol. 186 Issue 1, p58; Thesaurus Term: RNA; Subject Term: DNA microarrays; Subject Term: Clinical pathology; Subject Term: Clinical medicine; Subject Term: Medical care; Subject Term: Gene expression; Subject Term: Performance evaluation; Author-Supplied Keyword: Metrics; Author-Supplied Keyword: Microarray; Author-Supplied Keyword: Standards; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.toxlet.2008.08.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36898909&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Soneson, Joshua E.
T1 - A User-Friendly Software Package for HIFU Simulation.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2009/04/14/
VL - 1113
IS - 1
M3 - Article
SP - 165
EP - 169
PB - American Institute of Physics
SN - 0094243X
AB - A freely-distributed, MATLAB (The Mathworks, Inc., Natick, MA)-based software package for simulating axisymmetric high-intensity focused ultrasound (HIFU) beams and their heating effects is discussed. The package (HIFU_Simulator) consists of a propagation module which solves the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation and a heating module which solves Pennes’ bioheat transfer (BHT) equation. The pressure, intensity, heating rate, temperature, and thermal dose fields are computed, plotted, the output is released to the MATLAB workspace for further user analysis or postprocessing. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMPUTER software development
KW - HIGH-intensity focused ultrasound
KW - IMAGING systems in medicine
KW - THERMAL properties
KW - NONLINEAR acoustics
KW - nonlinear acoustics
KW - numerical methods
KW - Software
N1 - Accession Number: 37831689; Soneson, Joshua E. 1; Email Address: joshua.soneson@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: 4/14/2009, Vol. 1113 Issue 1, p165; Subject Term: COMPUTER software development; Subject Term: HIGH-intensity focused ultrasound; Subject Term: IMAGING systems in medicine; Subject Term: THERMAL properties; Subject Term: NONLINEAR acoustics; Author-Supplied Keyword: nonlinear acoustics; Author-Supplied Keyword: numerical methods; Author-Supplied Keyword: Software; NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); Number of Pages: 5p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1063/1.3131405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37831689&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Maruvada, Subha
AU - Liu, Yunbo
AU - Herman, Bruce A.
AU - Harris, Gerald R.
T1 - Temperature Measurements in Tissue-Mimicking Material during HIFU Exposure.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2009/04/14/
VL - 1113
IS - 1
M3 - Article
SP - 286
EP - 290
PB - American Institute of Physics
SN - 0094243X
AB - Cavitation in high intensity focused ultrasound (HIFU) procedures can yield unpredictable results, particularly when the same location is targeted for more than several seconds. To study this effect, temperature rise was measured in tissue mimicking material (TMM) during HIFU exposures. A 50 um thin wire thermocouple (TC) was embedded in the center of a hydrogel-based TMM that was previously developed for HIFU applications. HIFU at 825 kHz was focused at the TC junction. Thirty second HIFU exposures of increasing pressure from 1–7 MPa were applied and the temperature rise and decay during and after sonication were recorded. B-mode imaging was used to monitor any cavitation activity during sonication. If cavitation was noted during the sonication, the sonication was repeated at the same pressure level two more times at 20 minute intervals in order to characterize the repeatability given that cavitation had occurred. The cavitation threshold of the TMM was determined to be approximately 3 MPa at 825 kHz. Temperature traces obtained at various pressure levels demonstrated a wide range of heating profiles in the TMM due to the occurrence of cavitation. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH-intensity focused ultrasound
KW - IMAGING systems in medicine
KW - HYDROGELS
KW - THERMOELECTRIC apparatus & appliances
KW - EVALUATION
KW - CAVITATION
KW - Cavitation
KW - HIFU
KW - Tissue-mimicking material
N1 - Accession Number: 37831663; Maruvada, Subha 1 Liu, Yunbo 1 Herman, Bruce A. 1 Harris, Gerald R. 1; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave., Silver Spring, MD, 20993; Source Info: 4/14/2009, Vol. 1113 Issue 1, p286; Subject Term: HIGH-intensity focused ultrasound; Subject Term: IMAGING systems in medicine; Subject Term: HYDROGELS; Subject Term: THERMOELECTRIC apparatus & appliances; Subject Term: EVALUATION; Subject Term: CAVITATION; Author-Supplied Keyword: Cavitation; Author-Supplied Keyword: HIFU; Author-Supplied Keyword: Tissue-mimicking material; Number of Pages: 5p; Illustrations: 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1063/1.3131432
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37831663&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yunbo Liu
AU - Maruvada, Subha
AU - King, Randy L.
AU - Herman, Bruce A.
AU - Wear, Keith A.
T1 - Temperature-dependent Physical Properties of a HIFU Blood Mimicking Fluid.
JO - AIP Conference Proceedings
JF - AIP Conference Proceedings
Y1 - 2009/04/14/
VL - 1113
IS - 1
M3 - Article
SP - 291
EP - 295
PB - American Institute of Physics
SN - 0094243X
AB - A blood mimicking fluid (BMF) has been developed and characterized in a temperature dependent manner for high intensity focused ultrasound (HIFU) ablation devices. The BMF is based on a degassed and de-ionized water solution dispersed with low density polyethylene micro-spheres, nylon particles, gellan gum and glycerol. A broad range of physical parameters, including frequency dependent ultrasound attenuation, speed of sound, viscosity, thermal conductivity and diffusivity were characterized as a function of temperature (20° C to 70° C). The nonlinear parameter B/A and backscatter coefficient were also measured at room temperature. The attenuation coefficient is linearly proportional to the frequency (2 MHz–8 MHz) with a slope of about 0.2 dB cm-1 MHz-1 in the 20° C to 70° C range as has been reported for human blood. All the other temperature dependent physical parameters are also close to the reported values in human blood. These properties make the BMF a useful HIFU research tool for developing standardized exposimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU ablation devices. [ABSTRACT FROM AUTHOR]
AB - Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH-intensity focused ultrasound
KW - IMAGING systems in medicine
KW - THERMAL conductivity
KW - THERMAL diffusivity
KW - SPEED of sound
KW - blood mimicking fluid
KW - HIFU
KW - thermal ablation
KW - ultrasound characterization
N1 - Accession Number: 37831662; Yunbo Liu 1 Maruvada, Subha 1 King, Randy L. 2 Herman, Bruce A. 1 Wear, Keith A. 1; Affiliation: 1: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993 2: Department of Bioengineering, Stanford University, Stanford, CA, 94305; Source Info: 4/14/2009, Vol. 1113 Issue 1, p291; Subject Term: HIGH-intensity focused ultrasound; Subject Term: IMAGING systems in medicine; Subject Term: THERMAL conductivity; Subject Term: THERMAL diffusivity; Subject Term: SPEED of sound; Author-Supplied Keyword: blood mimicking fluid; Author-Supplied Keyword: HIFU; Author-Supplied Keyword: thermal ablation; Author-Supplied Keyword: ultrasound characterization; Number of Pages: 5p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1063/1.3131433
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37831662&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105518127
T1 - Screening for bacterial vaginosis in pregnancy to prevent preterm delivery.
AU - Lin KW
AU - LoBrano MB
Y1 - 2009/04/15/
N1 - Accession Number: 105518127. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Childbirth, Premature -- Etiology
KW - Childbirth, Premature -- Prevention and Control
KW - Pregnancy Complications, Infectious -- Diagnosis
KW - Vaginosis, Bacterial -- Diagnosis
KW - Adult
KW - Female
KW - Pregnancy Complications, Infectious -- Etiology
KW - Pregnancy
KW - Risk Factors
KW - Vaginosis, Bacterial -- Complications
SP - 697
EP - 698
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 8
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19405414.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105518127&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Li, Jiebo
AU - Tan, Zhiwu
AU - Tang, Shixing
AU - Hewlett, Indira
AU - Pang, Ruifang
AU - He, Meizi
AU - He, Shanshan
AU - Tian, Baohe
AU - Chen, Kan
AU - Yang, Ming
T1 - Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
Y1 - 2009/04/15/
VL - 17
IS - 8
M3 - Article
SP - 3177
EP - 3188
SN - 09680896
AB - Abstract: HIV-1 assembly and disassembly (uncoating) processes are critical for the HIV-1 replication. HIV-1 capsid (CA) and human cyclophilin A (CypA) play essential roles in these processes. We designed and synthesized a series of thiourea compounds as HIV-1 assembly and disassembly dual inhibitors targeting both HIV-1 CA protein and human CypA. The SIV-induced syncytium antiviral evaluation indicated that all of the inhibitors displayed antiviral activities in SIV-infected CEM cells at the concentration of 0.6–15.8μM for 50% of maximum effective rate. Their abilities to bind CA and CypA were determined by ultraviolet spectroscopic analysis, fluorescence binding affinity and PPIase inhibition assay. Assembly studies in vitro demonstrated that the compounds could potently disrupt CA assembly with a dose-dependent manner. All of these molecules could bind CypA with binding affinities (Kd values) of 51.0–512.8μM. Fifteen of the CypA binding compounds showed potent PPIase inhibitory activities (IC50 values<1μM) while they could not bind either to HIV-1 Protease or to HIV-1 Integrase in the enzyme assays. These results suggested that 15 compounds could block HIV-1 replication by inhibiting the PPIase activity of CypA to interfere with capsid disassembly and disrupting CA assembly. [Copyright &y& Elsevier]
AB - Copyright of Bioorganic & Medicinal Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV (Viruses)
KW - PEPTIDYLPROLYL isomerase
KW - VIRAL proteins
KW - THIOUREA
KW - CHEMICAL inhibitors
KW - ANTIVIRAL agents
KW - VIRAL replication
KW - PREVENTION
KW - THERAPEUTIC use
KW - Assembly
KW - Capsid
KW - Cyclophilin A
KW - Disassembly
KW - Dual inhibitor
KW - HIV-1
N1 - Accession Number: 37573198; Li, Jiebo 1 Tan, Zhiwu 1 Tang, Shixing 2 Hewlett, Indira 2 Pang, Ruifang 1 He, Meizi 1 He, Shanshan 1 Tian, Baohe 1 Chen, Kan 1 Yang, Ming 1; Email Address: yangm@bjmu.edu.cn; Affiliation: 1: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, PO Box 261, Beijing 100191, China 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2009, Vol. 17 Issue 8, p3177; Subject Term: HIV (Viruses); Subject Term: PEPTIDYLPROLYL isomerase; Subject Term: VIRAL proteins; Subject Term: THIOUREA; Subject Term: CHEMICAL inhibitors; Subject Term: ANTIVIRAL agents; Subject Term: VIRAL replication; Subject Term: PREVENTION; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Assembly; Author-Supplied Keyword: Capsid; Author-Supplied Keyword: Cyclophilin A; Author-Supplied Keyword: Disassembly; Author-Supplied Keyword: Dual inhibitor; Author-Supplied Keyword: HIV-1; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.bmc.2009.02.051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37573198&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tian, Baohe
AU - He, Meizi
AU - Tang, Shixing
AU - Hewlett, Indira
AU - Tan, Zhiwu
AU - Li, Jiebo
AU - Jin, Yinxue
AU - Yang, Ming
T1 - Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
Y1 - 2009/04/15/
VL - 19
IS - 8
M3 - Article
SP - 2162
EP - 2167
SN - 0960894X
AB - Abstract: HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17μΜ, respectively. [Copyright &y& Elsevier]
AB - Copyright of Bioorganic & Medicinal Chemistry Letters is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - HIV infections
KW - VIRAL proteins
KW - VIRAL replication
KW - DRUGS -- Derivatives
KW - CELL-mediated cytotoxicity
KW - Acylhydrazones
KW - Antiviral activity
KW - HIV-1 capsid
KW - Synthesis
N1 - Accession Number: 37347478; Tian, Baohe 1 He, Meizi 1 Tang, Shixing 2 Hewlett, Indira 2 Tan, Zhiwu 1 Li, Jiebo 1 Jin, Yinxue 1 Yang, Ming 1; Email Address: yangm@bjmu.edu.cn; Affiliation: 1: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, PO Box 261, Beijing 100191, China 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Apr2009, Vol. 19 Issue 8, p2162; Subject Term: ANTIVIRAL agents; Subject Term: HIV infections; Subject Term: VIRAL proteins; Subject Term: VIRAL replication; Subject Term: DRUGS -- Derivatives; Subject Term: CELL-mediated cytotoxicity; Author-Supplied Keyword: Acylhydrazones; Author-Supplied Keyword: Antiviral activity; Author-Supplied Keyword: HIV-1 capsid; Author-Supplied Keyword: Synthesis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.bmcl.2009.02.116
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37347478&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Farley, Donna O.
AU - Battles, James B.
T1 - Evaluation of the AHRQ Patient Safety Initiative: Framework and Approach.
JO - Health Services Research
JF - Health Services Research
Y1 - 2009/04/15/
VL - 44
IS - 2p2
M3 - Article
SP - 628
EP - 645
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. Describe the evaluation performed of the patient safety initiative operated by the Agency for Healthcare Research and Quality (AHRQ). AHRQ Patient Safety Initiative. When patient safety became a national priority in 2000, Congress charged and funded AHRQ to improve health care safety. Over the next 6 years, AHRQ funded more than 300 research projects and other activities, addressing diverse patient safety issues and practices. The Patient Safety Evaluation. AHRQ contracted with RAND in 2002 to perform a 4-year evaluation of the initiative, which was completed in 2006. This formative evaluation used the CIPP program evaluation model, which emphasizes multiple stakeholders' interests (e.g., patients, providers, funded researchers). We monitored the progress of the patient safety initiative and provided AHRQ annual feedback that assessed each year's activities, identifying issues and offering suggestions for actions by AHRQ. Given the size and complexity of the initiative, the evaluation needed to examine key individual components and synthesize results across them, and it also had to be responsive to changes in the initiative over time. We used a conceptual framework to bring together the disparate pieces to synthesize overall findings. The remaining articles in this issue describe selected results from this evaluation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITY of life
KW - HEALTH risk assessment
KW - PATIENTS -- Safety measures
KW - MEDICAL care
KW - UNITED States
KW - evaluation design and research
KW - Program evaluation
KW - quality care-patient safety (measurement)
KW - quality carepatient safety (measurement)
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 36892795; Farley, Donna O. 1; Email Address: farley@rand.org Battles, James B. 2; Affiliation: 1: RAND Corporation, 4570 Fifth Avenue, Suite 600, Pittsburgh, PA 15213 2: Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD; Source Info: Apr2009, Vol. 44 Issue 2p2, p628; Subject Term: QUALITY of life; Subject Term: HEALTH risk assessment; Subject Term: PATIENTS -- Safety measures; Subject Term: MEDICAL care; Subject Term: UNITED States; Author-Supplied Keyword: evaluation design and research; Author-Supplied Keyword: Program evaluation; Author-Supplied Keyword: quality care-patient safety (measurement); Author-Supplied Keyword: quality carepatient safety (measurement); Company/Entity: UNITED States. Agency for Healthcare Research & Quality; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 18p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1475-6773.2008.00931.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36892795&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Joffe, Hylton V.
T1 - CONTROVERSIES IN TREATING DIABETES: CLINICAL AND RESEARCH ASPECTS.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/04/15/
VL - 301
IS - 15
M3 - Book Review
SP - 1603
EP - 1604
SN - 00987484
AB - The article reviews the book "Controversies in Treating Diabetes: Clinical and Research Aspects," by Derek Le Roith and Aaron I. Vinik.
KW - DIABETES
KW - NONFICTION
KW - VINIK, Aaron I.
KW - LE Roith, Derek
KW - CONTROVERSIES in Treating Diabetes: Clinical & Research Aspects (Book)
N1 - Accession Number: 37584478; Joffe, Hylton V. 1; Email Address: hjoffe1@hotmail.com; Affiliation: 1: US Food and Drug Administration Silver Spring Maryland; Source Info: 4/15/2009, Vol. 301 Issue 15, p1603; Subject Term: DIABETES; Subject Term: NONFICTION; Reviews & Products: CONTROVERSIES in Treating Diabetes: Clinical & Research Aspects (Book); People: VINIK, Aaron I.; People: LE Roith, Derek; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Colman, Eric
T1 - THE METABOLIC SYNDROME AND OBESITY.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/04/15/
VL - 301
IS - 15
M3 - Book Review
SP - 1605
EP - 1606
SN - 00987484
AB - The article reviews the book "The Metabolic Syndrome and Obesity," by George A. Bray.
KW - OBESITY
KW - NONFICTION
KW - BRAY, George A.
KW - METABOLIC Syndrome & Obesity, The (Book)
N1 - Accession Number: 37584485; Colman, Eric 1; Email Address: eric.colman@fda.hhs.gov; Affiliation: 1: Division of Metabolism and Endocrinology Products Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring, Maryland; Source Info: 4/15/2009, Vol. 301 Issue 15, p1605; Subject Term: OBESITY; Subject Term: NONFICTION; Reviews & Products: METABOLIC Syndrome & Obesity, The (Book); People: BRAY, George A.; Number of Pages: 2p; Document Type: Book Review
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Allen, Courtni E.
AU - Schmitt, Michael P.
T1 - HtaA Is an Iron-Regulated Hemin Binding Protein Involved in the Utilization of Heme Iron in Corynebacterium diphtheriae.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2009/04/15/
VL - 191
IS - 8
M3 - Article
SP - 2638
EP - 2648
SN - 00219193
AB - Many human pathogens, including Corynebacterium diphtheriae, the causative agent of diphtheria, use host compounds such as heme and hemoglobin as essential iron sources. In this study, we examined the Corynebacterium hmu hemin transport region, a genetic cluster that contains the hmuTUV genes encoding a previously described ABC-type hemin transporter and three additional genes, which we have designated htaA, htaB, and htaC. The hmu gene cluster is composed of three distinct transcriptional units. The htaA gene appears to be part of an iron- and DtxR-regulated operon that includes hmuTUV, while htaB and htaC are transcribed from unique DtxR-regulated promoters. Nonpolar deletion of either htaA or the hmuTUV genes resulted in a reduced ability to use hemin as an iron source, while deletion of htaB had no effect on hemin iron utilization in C. diphtheriae. A comparison of the predicted amino acid sequences of HtaA and HtaB showed that they share some sequence similarity, and both proteins contain leader sequences and putative C-terminal transmembrane regions. Protein localization studies with C. diphtheriae showed that HtaA is associated predominantly with the cell envelope when the organism is grown in minimal medium but is secreted during growth in nutrient-rich broth. HtaB and HmuT were detected primarily in the cytoplasmic membrane fraction regardless of the growth medium. Hemin binding studies demonstrated that HtaA and HtaB are able to bind hemin, suggesting that these proteins may function as cell surface hemin receptors in C. diphtheriae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATHOGENIC microorganisms
KW - MICROORGANISMS
KW - MEDICAL microbiology
KW - CORYNEBACTERIUM diphtheriae
KW - CORYNEBACTERIUM
KW - BIOMOLECULES
KW - CARRIER proteins
KW - HEMOGLOBIN polymorphisms
KW - ORGANIC acids
N1 - Accession Number: 38312498; Allen, Courtni E. 1 Schmitt, Michael P. 1; Email Address: michael.schmitt@fda.hhs.gov; Affiliation: 1: Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: Apr2009, Vol. 191 Issue 8, p2638; Subject Term: PATHOGENIC microorganisms; Subject Term: MICROORGANISMS; Subject Term: MEDICAL microbiology; Subject Term: CORYNEBACTERIUM diphtheriae; Subject Term: CORYNEBACTERIUM; Subject Term: BIOMOLECULES; Subject Term: CARRIER proteins; Subject Term: HEMOGLOBIN polymorphisms; Subject Term: ORGANIC acids; Number of Pages: 11p; Document Type: Article
L3 - 10.1128/JB.01784-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38312498&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reed, Jennifer L.
AU - Welliver, Timothy P.
AU - Sims, Gary P.
AU - McKinney, LuAnn
AU - Velozo, Luis
AU - Avendano, Luis
AU - Hintz, Karen
AU - Luma, Jayson
AU - Coyle, Anthony J.
AU - Welliver Sr., Robert C.
T1 - Innate Immune Signals Modulate Antiviral and Polyreactive Antibody Responses during Severe Respiratory Syncytial Virus Infection.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/04/15/
VL - 199
IS - 8
M3 - Article
SP - 1128
EP - 1138
SN - 00221899
AB - Antiviral antibody production during respiratory syncytial virus (RSV) infection in infants is poorly understood. Tocharacterize local Blymphocyte responses, lung tissue and secretions from infants withRSVbronchiolitis were analyzed for innate B cell-stimulating factors and antiviral antibodies. In lung tissues of infants with fatal RSV bronchiolitis, CD20+ lymphocytes and IgM-positive, IgG-positive, and IgA-positive plasma cells were prominent but CD4+ T lymphocytes were not. Type I interferon-induced proteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), were colocalized in infected epithelium. In nasopharyngeal secretions from infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were detected at presentation and correlated with BAFF and APRIL levels. Expression of APRIL and antiviral antibodies of IgA and IgM but not IgG isotype predicted better oxygen saturation. We conclude that B lymphocyte-stimulating factors derived from infected epithelium are primary determinants of the mucosal antibody response in infant RSV bronchiolitis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - RESPIRATORY syncytial virus infections
KW - INFANTS -- Care
KW - B cells
KW - CELL proliferation
KW - EPITHELIUM
KW - LYMPHOID tissue
KW - IMMUNE response -- Regulation
KW - PUBLIC health
KW - TREATMENT
N1 - Accession Number: 38022007; Reed, Jennifer L. 1 Welliver, Timothy P. 2,3 Sims, Gary P. 2 McKinney, LuAnn 2 Velozo, Luis 4 Avendano, Luis 5 Hintz, Karen 6 Luma, Jayson 6 Coyle, Anthony J. 2 Welliver Sr., Robert C. 6; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville 2: Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland 3: Department of Immunology, University of Michigan, Ann Arbor, MI 4: Unidad de Anatomía Patológica, Hospital Roberto del Río 5: Programa de Virología, Universidad de Chile, Santiago, Chile 6: Department of Pediatrics, Women and Children's Hospital, State University of New York at Buffalo, Buffalo, New York; Source Info: 4/15/2009, Vol. 199 Issue 8, p1128; Subject Term: ANTIVIRAL agents; Subject Term: RESPIRATORY syncytial virus infections; Subject Term: INFANTS -- Care; Subject Term: B cells; Subject Term: CELL proliferation; Subject Term: EPITHELIUM; Subject Term: LYMPHOID tissue; Subject Term: IMMUNE response -- Regulation; Subject Term: PUBLIC health; Subject Term: TREATMENT; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3 - 10.1086/597386
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38022007&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105518111
T1 - Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection.
AU - Reed JL
AU - Welliver TP
AU - Sims GP
AU - McKinney L
AU - Velozo L
AU - Avendano L
AU - Hintz K
AU - Luma J
AU - Coyle AJ
AU - Welliver RC Sr
Y1 - 2009/04/15/
N1 - Accession Number: 105518111. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Antibodies, Viral -- Blood
KW - B Lymphocytes -- Physiology
KW - Immunity -- Immunology
KW - Respiratory Syncytial Virus Infections -- Immunology
KW - Signal Transduction -- Immunology
KW - Antibodies, Viral -- Metabolism
KW - Immunoglobulins -- Blood
KW - Immunoglobulins -- Metabolism
KW - Infant
KW - Lung -- Immunology
KW - Lung -- Pathology
KW - Oxygen -- Metabolism
KW - Respiratory Syncytial Virus Infections -- Pathology
KW - T Lymphocytes -- Physiology
SP - 1128
EP - 1138
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 199
IS - 8
PB - Oxford University Press / USA
AB - Antiviral antibody production during respiratory syncytial virus (RSV) infection in infants is poorly understood. To characterize local B lymphocyte responses, lung tissue and secretions from infants with RSV bronchiolitis were analyzed for innate B cell-stimulating factors and antiviral antibodies. In lung tissues of infants with fatal RSV bronchiolitis, CD20(+) lymphocytes and IgM-positive, IgG-positive, and IgA-positive plasma cells were prominent but CD4(+) T lymphocytes were not. Type I interferon-induced proteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), were colocalized in infected epithelium. In nasopharyngeal secretions from infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were detected at presentation and correlated with BAFF and APRIL levels. Expression of APRIL and antiviral antibodies of IgA and IgM but not IgG isotype predicted better oxygen saturation. We conclude that B lymphocyte-stimulating factors derived from infected epithelium are primary determinants of the mucosal antibody response in infant RSV bronchiolitis. Copyright © 2009 Infectious Diseases Society of America
SN - 0022-1899
AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. jennifer.reed@fda.hhs.gov
U2 - PMID: 19278337.
DO - 10.1086/597386
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105518111&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Young, John F.
AU - Luecke, Richard H.
AU - Pearce, Bruce A.
AU - Lee, Taewon
AU - Ahn, Hongshik
AU - Baek, Songjoon
AU - Moon, Hojin
AU - Dye, Daniel W.
AU - Davis, Thomas M.
AU - Taylor, Susan J.
T1 - Human Organ/Tissue Growth Algorithms that Include Obese Individuals and Black/White Population Organ Weight Similarities from Autopsy Data.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2009/04/15/
VL - 72
IS - 8
M3 - Article
SP - 527
EP - 540
SN - 15287394
AB - Physiologically based pharmacokinetic (PBPK) models need the correct organ/tissue weights to match various total body weights in order to be applied to children and the obese individual. Baseline data from Reference Man for the growth of human organs (adrenals, brain, heart, kidneys, liver, lungs, pancreas, spleen, thymus, and thyroid) were augmented with autopsy data to extend the describing polynomials to include the morbidly obese individual (up to 250 kg). Additional literature data similarly extends the growth curves for blood volume, muscle, skin, and adipose tissue. Collectively these polynomials were used to calculate blood/organ/tissue weights for males and females from birth to 250 kg, which can be directly used to help parameterize PBPK models. In contrast to other black/white anthropomorphic measurements, the data demonstrated no observable or statistical difference in weights for any organ/tissue between individuals identified as black or white in the autopsy reports. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - HUMAN physiology
KW - BODY weight
KW - OVERWEIGHT persons
KW - ORGANS (Anatomy)
KW - TISSUES -- Physiology
KW - DRUG development
KW - HUMAN body composition
KW - ADIPOSE tissues
KW - AUTOPSY
N1 - Accession Number: 36838953; Young, John F. 1; Email Address: johnfyoung@aristotle.net Luecke, Richard H. 2 Pearce, Bruce A. 3 Lee, Taewon 1 Ahn, Hongshik 4 Baek, Songjoon 1 Moon, Hojin 5 Dye, Daniel W. 6 Davis, Thomas M. 6 Taylor, Susan J. 1; Affiliation: 1: Division of Personalized Nutrition & Medicine, National Center for Toxicological Research, Jefferson, Arkansas 2: Department of Chemical Engineering, University of Missouri-Columbia, Columbia, Missouri 3: Information Technology Staff, National Center for Toxicological Research, Jefferson, Arkansas 4: Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 5: Department of Mathematics and Statistics, California State University-Long Beach, Long Beach, California 6: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Source Info: Apr2009, Vol. 72 Issue 8, p527; Subject Term: PHARMACOKINETICS; Subject Term: HUMAN physiology; Subject Term: BODY weight; Subject Term: OVERWEIGHT persons; Subject Term: ORGANS (Anatomy); Subject Term: TISSUES -- Physiology; Subject Term: DRUG development; Subject Term: HUMAN body composition; Subject Term: ADIPOSE tissues; Subject Term: AUTOPSY; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 14p; Illustrations: 6 Charts, 9 Graphs; Document Type: Article
L3 - 10.1080/15287390802647203
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=36838953&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, Hongwen
AU - Joseph K. Ma
AU - Barger, Mark W.
AU - Mercer, Robert R.
AU - Millecchia, Lyndell
AU - Schwegler-Berry, Diane
AU - Castranova, Vince
AU - Jane Y. Ma
T1 - Reactive Oxygen Species- and Nitric Oxide-Mediated Lung Inflammation and Mitochondrial Dysfunction in Wild-Type and iNOS-Deficient Mice Exposed to Diesel Exhaust Particles.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2009/04/15/
VL - 72
IS - 8
M3 - Article
SP - 560
EP - 570
SN - 15287394
AB - Pulmonary responses to diesel exhaust particles (DEP) exposure are mediated through enhanced production of reactive oxygen species (ROS) and nitric oxide (NO) by alveolar macrophages (AM). The current study examined the differential roles of ROS and NO in DEP-induced lung injury using C57B/6J wild-type (WT) and inducible NO synthase knockout (iNOS KO) mice. Mice exposed by pharyngeal aspiration to DEP or carbon black particles (CB) (35 mg/kg) showed an inflammatory profile that included neutrophil infiltration, increased lactate dehydrogenase (LDH) activity, and elevated albumin content in bronchoalveolar lavage fluid (BALF) at 1, 3, and 7 d postexposure. The organic extract of DEP (DEPE) did not induce an inflammatory response. Comparing WT to iNOS KO mice, the results show that NO enhanced DEP-induced neutrophils infiltration and plasma albumin content in BALF and upregulated the production of the pro-inflammatory cytokine interleukin 12 (IL-12) by AM. DEP-exposed AM from iNOS KO mice displayed diminished production of IL-12 and, in response to ex vivo lipopolysaccharide (LPS) challenge, decreased production of IL-12 but increased production of IL-10 when compared to cells from WT mice. DEP, CB, but not DEPE, induced DNA damage and mitochondria dysfunction in AM, however, that is independent of cellular production of NO. These results demonstrate that DEP-induced immune/inflammatory responses in mice are regulated by both ROS- and NO-mediated pathways. NO did not affect ROS-mediated mitochondrial dysfunction and DNA damage but upregulated IL-12 and provided a counterbalance to the ROS-mediated adaptive stress response that downregulates IL-12 and upregulates IL-10. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LUNGS -- Wounds & injuries
KW - MICE as laboratory animals
KW - ACTIVE oxygen
KW - NITRIC oxide
KW - MACROPHAGES
KW - DIESEL motor exhaust gas
KW - LACTATE dehydrogenase
KW - BRONCHOALVEOLAR lavage
KW - SERUM albumin
KW - IMMUNE response
N1 - Accession Number: 36838950; Zhao, Hongwen 1,2 Joseph K. Ma 3 Barger, Mark W. 1 Mercer, Robert R. 1 Millecchia, Lyndell 1 Schwegler-Berry, Diane 1 Castranova, Vince 1 Jane Y. Ma 1; Email Address: jym1@cdc.gov; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 2: Institute of Respiratory Diseases, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China 3: School of Pharmacy, West, Virginia University, Morgantown, West Virginia, USA; Source Info: Apr2009, Vol. 72 Issue 8, p560; Subject Term: LUNGS -- Wounds & injuries; Subject Term: MICE as laboratory animals; Subject Term: ACTIVE oxygen; Subject Term: NITRIC oxide; Subject Term: MACROPHAGES; Subject Term: DIESEL motor exhaust gas; Subject Term: LACTATE dehydrogenase; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: SERUM albumin; Subject Term: IMMUNE response; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1080/15287390802706330
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Alarcon, W. A.
AU - Roscoe, R. J.
AU - Calvert, G. M.
AU - Graydon, J. R.
T1 - Adult Blood Lead Epidemiology and Surveillance -- United States, 2005-2007.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2009/04/17/
VL - 58
IS - 14
M3 - Article
SP - 365
EP - 369
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article reports a summary of the results of the study done by the Centers for Disease Control's (CDC) Adult Blood Lead Epidemiology and Surveillance (ABLES) program on tracking laboratory-reported elevated blood lead levels (BLLs) of adults in the U.S. from 2005-2007. There was a decrease in the national rate of elevated BLLs among state residents and nonresidents from 14.0 in 1994 to 7.8 in 2007. Among the industries with the highest numbers of lead-exposed employees were manufacturing of storage batteries, painting, and paper hanging.
KW - LEAD
KW - BLOOD
KW - GOVERNMENT programs
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 38216451; Alarcon, W. A. 1 Roscoe, R. J. 1 Calvert, G. M. 1 Graydon, J. R. 1; Affiliation: 1: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC; Source Info: 4/17/2009, Vol. 58 Issue 14, p365; Subject Term: LEAD; Subject Term: BLOOD; Subject Term: GOVERNMENT programs; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 327992 Ground or Treated Mineral and Earth Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 327990 All other non-metallic mineral product manufacturing; Number of Pages: 5p; Illustrations: 1 Chart, 1 Graph, 1 Map; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Baozhong Zhao
AU - Yu-Ying He
AU - Colin F. Chignell
AU - Jun-Jie Yin
AU - Usha Andley
AU - Joan E. Roberts
T1 - Difference in Phototoxicity of Cyclodextrin Complexed Fullerene [(γ-CyD)2/C60] and Its Aggregated Derivatives toward Human Lens Epithelial Cells.
JO - Chemical Research in Toxicology
JF - Chemical Research in Toxicology
Y1 - 2009/04/20/
VL - 22
IS - 4
M3 - Article
SP - 660
EP - 667
SN - 0893228X
AB - The water-soluble fullerene derivative γ-cyclodextrin bicapped C60[(γ-CyD)2/C60, CDF0] has several clinical applications, including use as a drug carrier to bypass the blood ocular barriers or a photosensitizer to treat tumors in photodynamic therapy. We have assessed the potential ocular toxicity of (γ-CyD)2/C60and its aggregated derivatives induced by UVA and visible light in vitro in human lens epithelial cells (HLE B-3). Cell viability using the MTS assay demonstrated that 2 μM (γ-CyD)2/C60was highly phototoxic to HLE B-3 cells with UVA irradiation, while no effect was observed in the presence of visible light or when maintained in the dark. In contrast, the aggregated derivative (CDF150) showed neither cytotoxicity nor any phototoxic effect even at 30 μM with either UVA or visible light irradiation. In lens cells treated with (γ-CyD)2/C60, phototoxicity was manifested as apoptosis. Singlet oxygen production measurement using the EPR/TEMP trapping technique determined that (γ-CyD)2/C60(CDF0) efficiently produced singlet oxygen. The rate of singlet oxygen production decreased with increased aggregation, with no production by the fully aggregated sample formed after 150 min of heating (CDF150). UVA irradiation of HLE B-3 in the presence of (γ-CyD)2/C60resulted in a significant rise in intracellular protein-derived peroxides. The singlet oxygen quenchers sodium azide and histidine each significantly protected lens cells against (γ-CyD)2/C60photodamage, but lutein and Trolox (vitamin E) did not. Clearly, singlet oxygen is an important intermediate in the phototoxicity of monomeric (γ-CyD)2/fullerene. Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chemical Research in Toxicology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYCLODEXTRINS
KW - OCULAR toxicology
KW - FULLERENES
KW - DRUG carriers (Pharmacy)
KW - BIOLOGICAL photosensitization
KW - PHOTOTHERAPY
KW - EPITHELIAL cells
KW - CRYSTALLINE lens
KW - INTERMEDIATES (Chemistry)
N1 - Accession Number: 37832894; Baozhong Zhao 1 Yu-Ying He 1 Colin F. Chignell 1 Jun-Jie Yin 1 Usha Andley 1 Joan E. Roberts 1; Affiliation: 1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740, Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, Missouri 63110, and Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, New York 10023; Source Info: Apr2009, Vol. 22 Issue 4, p660; Subject Term: CYCLODEXTRINS; Subject Term: OCULAR toxicology; Subject Term: FULLERENES; Subject Term: DRUG carriers (Pharmacy); Subject Term: BIOLOGICAL photosensitization; Subject Term: PHOTOTHERAPY; Subject Term: EPITHELIAL cells; Subject Term: CRYSTALLINE lens; Subject Term: INTERMEDIATES (Chemistry); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Soung, Nak-Kyun
AU - Park, Jung-Eun
AU - Yu, Li-Rong
AU - Lee, Kyung H.
AU - Lee, Jung-Min
AU - Bang, Jeong K.
AU - Veenstra, Timothy D.
AU - Rhee, Kunsoo
AU - Lee, Kyung S.
T1 - Plk1-Dependent and -Independent Roles of an ODF2 Splice Variant, hCenexin1, at the Centrosome of Somatic Cells
JO - Developmental Cell
JF - Developmental Cell
Y1 - 2009/04/21/
VL - 16
IS - 4
M3 - Article
SP - 539
EP - 550
SN - 15345807
AB - Summary: Outer dense fiber 2 (ODF2) was initially identified as a major component of the sperm tail cytoskeleton, and was later suggested to be localized to somatic centrosomes and required for the formation of primary cilia. Here we show that a splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif within the extension. This interaction and Plk1 activity were important for proper recruitment of pericentrin and γ-tubulin, and, ultimately, for formation of normal bipolar spindles. Earlier in the cell cycle, hCenexin1, but again not hODF2, also contributed to centrosomal recruitment of ninein and primary cilia formation independent of Plk1 interaction. These findings provide a striking example of how a splice-generated C-terminal extension of a sperm tail-associating protein mediates unanticipated centrosomal events at distinct stages of the somatic cell cycle. [Copyright &y& Elsevier]
AB - Copyright of Developmental Cell is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENETIC engineering
KW - CENTROSOMES
KW - SOMATIC cells
KW - VARIATION (Biology)
KW - CYTOSKELETON
KW - CELL cycle
KW - CYTOLOGY
KW - CELLBIO
N1 - Accession Number: 37815541; Soung, Nak-Kyun 1 Park, Jung-Eun 1 Yu, Li-Rong 2 Lee, Kyung H. 1 Lee, Jung-Min 3 Bang, Jeong K. 4 Veenstra, Timothy D. 5 Rhee, Kunsoo 3 Lee, Kyung S. 1; Email Address: kyunglee@mail.nih.gov; Affiliation: 1: Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 2: Center for Proteomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA 3: School of Biological Sciences, Seoul National University, Seoul 151-742, South Korea 4: Korea Basic Science Institute, Busan 609-735, South Korea 5: Laboratory of Proteomics and Analytical Technologies, National Cancer Institute–Frederick, Frederick, MD 21702, USA; Source Info: Apr2009, Vol. 16 Issue 4, p539; Subject Term: GENETIC engineering; Subject Term: CENTROSOMES; Subject Term: SOMATIC cells; Subject Term: VARIATION (Biology); Subject Term: CYTOSKELETON; Subject Term: CELL cycle; Subject Term: CYTOLOGY; Author-Supplied Keyword: CELLBIO; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.devcel.2009.02.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Epstein-Barash, Hila
AU - Schichor, Iris
AU - Kwon, Albert H.
AU - Hall, Sherwood
AU - Lawlor, Michael W.
AU - Langer, Robert
AU - Kohane, Daniel S.
T1 - Prolonged duration local anesthesia with minimal toxicity.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2009/04/28/
VL - 106
IS - 17
M3 - Article
SP - 7125
EP - 7130
SN - 00278424
AB - Injectable local anesthetics that would last for many days could have a marked impact on periprocedural care and pain management. Formulations have often been limited in duration of action. or by systemic toxicity, local tissue toxicity from local anesthetics. and inflammation. To address those issues, we developed liposomal formulations of saxitoxin (SIX), a compound with ultrapotent local anesthetic properties buts little or no cytotoxicity. In vitro, the release of bupivacaine and STX from liposomes depended on the lipid composition and on whether dexamethasone was incorporated. In cell culture, bupivacaine. but not STX, was myotoxic (to C2C12 cells) and neurotoxic (to PC12 cells) in a concentrationand time-dependent manner. Liposomal formulations containing combinations of the above compounds produced sciatic nerve blockade lasting up to 7.5 days (with STX + dexamethasone liposomes) in male Sprague-Dawley rats. Systemic toxicity only occurred where high loadings of dexamethasone increased the release of liposomal SIX. Mild myotoxicity was only seen in formulations containing bupivacaine. There was no nerve injury on Epon-embedded sections, and these liposomes did not up-regulate the expression of 4 genes associated with nerve injury in the dorsal root ganglia. These results suggest that controlled release of SIX and similar compounds can provide very prolonged nerve blocks with minimal systemic and local toxicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LOCAL anesthesia
KW - SAXITOXIN
KW - TOXICITY testing
KW - RESEARCH
KW - PAIN management
KW - CELL culture
KW - LIPOSOMES
KW - RATS as laboratory animals
KW - liposomes
KW - myotoxicity
KW - neurotoxicity
KW - pain
KW - saxitoxin
N1 - Accession Number: 40309119; Epstein-Barash, Hila 1,2 Schichor, Iris 1,2 Kwon, Albert H. 2 Hall, Sherwood 3 Lawlor, Michael W. 4 Langer, Robert 2 Kohane, Daniel S. 1; Email Address: daniel.kohane@childrens.harvard.edu; Affiliation: 1: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA 2: Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA 02139, USA 3: Chemical Contaminants Branch HFS-716, Division of Bioanalytical Chemistry Office of Regulatory Science, U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA 4: Program in Genomics, Department of Medicine, Children's Hospital Boston, Boston, MA 02115, USA; Source Info: 4/28/2009, Vol. 106 Issue 17, p7125; Subject Term: LOCAL anesthesia; Subject Term: SAXITOXIN; Subject Term: TOXICITY testing; Subject Term: RESEARCH; Subject Term: PAIN management; Subject Term: CELL culture; Subject Term: LIPOSOMES; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: liposomes; Author-Supplied Keyword: myotoxicity; Author-Supplied Keyword: neurotoxicity; Author-Supplied Keyword: pain; Author-Supplied Keyword: saxitoxin; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zubkova, I.
AU - Choi, Y.H.
AU - Chang, E.
AU - Pirollo, K.
AU - Uren, T.
AU - Watanabe, H.
AU - Wells, F.
AU - Kachko, A.
AU - Krawczynski, K.
AU - Major, M.E.
T1 - T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation
JO - Vaccine
JF - Vaccine
Y1 - 2009/04/28/
VL - 27
IS - 19
M3 - Article
SP - 2594
EP - 2602
SN - 0264410X
AB - Abstract: A prime/boost vaccine strategy that transfects antigen-presenting cells using ligand-modified immunoliposomes to efficiently deliver plasmid DNA, followed by boosting with non-replicating recombinant adenovirus was used in chimpanzees to generate HCV-specific memory T-cells. Three chimpanzees (two vaccines, one control) were immunized with immunoliposomes complexed with DNA expressing NS3-NS5B or complexed with empty vector. Animals were boosted with adenovirus expressing NS3-NS5B, or non-recombinant adenovirus (control). Using liposome delivery we were able to obtain specific HCV responses following DNA priming in the chimpanzees. This data and mouse immunization studies confirm this as a more efficient delivery system than direct intramuscular inoculations with naked DNA. Subsequent to the adenovirus boost significant increases in peripheral HCV-specific T-cell responses and intrahepatic IFN-γ and CD3ɛ mRNA were also observed in the two vaccinated animals. Following challenge (100 CID50) both vaccinated animals showed immediate and significant control of viral replication (peak titers 3.7×104 and 9×103 IU/mL at weeks 1 and 2), which coincided with increases in HCV-specific T-cell responses. Viral kinetics in the control animal were comparable to historical controls with exponential increases in titer during the first several weeks. One vaccinated animal developed a low-level persistent infection (2×103 IU/mL) which correlated with a decrease in HCV-specific T-cell responses. Circulating virus isolated from both vaccinated animals showed ∼2-fold greater nonsynonymous mutation rates compared to controls and the nonsynonymous/synonymous mutation rate ratio was indicative of positive selection. These data suggest that although T-cell vaccines can induce immune responses capable of controlling HCV, they also induce high levels of immune pressure for the potential selection of escape mutants. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Immune response
KW - Microbial mutation
KW - Vaccination of animals
KW - Viral vaccines
KW - T cells
KW - Hepatitis C virus
KW - Chimpanzees as laboratory animals
KW - Antigen presenting cells
KW - Chimpanzee
KW - Immune escape
KW - T-cell
N1 - Accession Number: 37577067; Zubkova, I. 1; Choi, Y.H. 2; Chang, E. 3; Pirollo, K. 3; Uren, T. 1; Watanabe, H. 1; Wells, F. 1; Kachko, A. 1; Krawczynski, K. 2; Major, M.E. 1; Email Address: marian.major@fda.hhs.gov; Affiliations: 1: Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; 2: Division of Viral Hepatitis, NCHHSTP, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA; Issue Info: Apr2009, Vol. 27 Issue 19, p2594; Thesaurus Term: Immune response; Thesaurus Term: Microbial mutation; Thesaurus Term: Vaccination of animals; Subject Term: Viral vaccines; Subject Term: T cells; Subject Term: Hepatitis C virus; Subject Term: Chimpanzees as laboratory animals; Subject Term: Antigen presenting cells; Author-Supplied Keyword: Chimpanzee; Author-Supplied Keyword: Immune escape; Author-Supplied Keyword: T-cell; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.02.045
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Choi, Jeong-Heui
AU - Mamun, M.I.R.
AU - El-Aty, A.M. Abd
AU - Kim, Kyung Tae
AU - Koh, Hong-Bum
AU - Shin, Ho-Chul
AU - Kim, Jin-Suk
AU - Lee, Kang Bong
AU - Shim, Jae-Han
T1 - Inert matrix and Na4EDTA improve the supercritical fluid extraction efficiency of fluoroquinolones for HPLC determination in pig tissues
JO - Talanta
JF - Talanta
Y1 - 2009/04/30/
VL - 78
IS - 2
M3 - Article
SP - 348
EP - 357
SN - 00399140
AB - Abstract: A supercritical fluid extraction method combined with high-performance liquid chromatography-fluorescence detection was developed for the determination of enrofloxacin, danofloxacin, and ciprofloxacin in pig muscle, lung, and kidney samples. The optimal SFE conditions were 80°C, 300kg/cm2, 30% methanol for 40min as a dynamic extraction time, in addition to 0.2g Na4EDTA and 7.0g sea sand in the extraction vessel. The use of Na4EDTA and sea sand on SFE extraction resulted in improvement of the recoveries of ciprofloxacin, a polar and hydrophilic compound, as well as enrofloxacin and danofloxacin. Overall, the recoveries ranged from 86.7 to 113.1% using the Na4EDTA/sea sand-assisted SFE extraction method. The Na4EDTA/sea sand-assisted SFE-HPLC-FLD validated method was successfully carried out in pig tissues, and proved to be specific, sensitive, reliable, and accurate. The method was also applied satisfactorily for accurate quantitative residue analysis in incurred pig tissues. [Copyright &y& Elsevier]
AB - Copyright of Talanta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUPERCRITICAL fluid extraction
KW - ETHYLENEDIAMINETETRAACETIC acid
KW - QUINOLONE antibacterial agents
KW - HIGH performance liquid chromatography
KW - CIPROFLOXACIN
KW - TISSUES -- Analysis
KW - QUANTITATIVE chemical analysis
KW - SWINE as laboratory animals
KW - Fluoroquinolones
KW - Inert matrix
KW - Na4EDTA
KW - Pig tissues
KW - Supercritical fluid extraction
N1 - Accession Number: 36475567; Choi, Jeong-Heui 1 Mamun, M.I.R. 1,2 El-Aty, A.M. Abd 3,4; Email Address: abdelaty44@hotmail.com Kim, Kyung Tae 1 Koh, Hong-Bum 5 Shin, Ho-Chul 3 Kim, Jin-Suk 3 Lee, Kang Bong 6 Shim, Jae-Han 1; Email Address: jhshim@jnu.ac.kr; Affiliation: 1: Natural Products Chemistry Laboratory, Division of Applied Bioscience and Biotechnology, College of Agriculture and Life Science, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea 2: Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh 3: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul, Republic of Korea 4: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt 5: Department of Veterinary Medicine, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea 6: Division of Food and Risk Standardization, Korea Food and Drug Administration, Seoul 122-704,Republic of Korea; Source Info: Apr2009, Vol. 78 Issue 2, p348; Subject Term: SUPERCRITICAL fluid extraction; Subject Term: ETHYLENEDIAMINETETRAACETIC acid; Subject Term: QUINOLONE antibacterial agents; Subject Term: HIGH performance liquid chromatography; Subject Term: CIPROFLOXACIN; Subject Term: TISSUES -- Analysis; Subject Term: QUANTITATIVE chemical analysis; Subject Term: SWINE as laboratory animals; Author-Supplied Keyword: Fluoroquinolones; Author-Supplied Keyword: Inert matrix; Author-Supplied Keyword: Na4EDTA; Author-Supplied Keyword: Pig tissues; Author-Supplied Keyword: Supercritical fluid extraction; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.talanta.2008.11.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105519312
T1 - Nonhuman primate research: the wrong way to understand needs and necessity.
AU - Rossi J
Y1 - 2009/05//
N1 - Accession Number: 105519312. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article; commentary. Original Study: Sughrue ME, Mocco J, Mack WJ, Ducruet AF, Komotar RJ, Fischbach RL, et al. Bioethical considerations in translational research: primate stroke. (AM J BIOETHICS) May2009; 9 (5): 3-12. Commentary: Sughrue ME, Mocco J, Mack WJ, Ducruet AF, Komotar RJ, Fischbach RL, et al. Response to open peer commentaries on 'Bioethical considerations in translational research: primate stroke'. (AM J BIOETHICS) May2009; 9 (5): W1-3. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100898738.
KW - Animal Studies -- Ethical Issues
KW - Cognition
KW - Models, Biological
KW - Morals
KW - Primates
KW - Research Ethics
KW - Stroke
KW - Suffering
KW - Anxiety -- Etiology
KW - Ethics Theory
KW - Stress, Psychological -- Etiology
SP - 21
EP - 23
JO - American Journal of Bioethics
JF - American Journal of Bioethics
JA - AM J BIOETHICS
VL - 9
IS - 5
CY - Oxfordshire,
PB - Routledge
SN - 1526-5161
AD - Office of Pediatric Therapeutics, Food and Drug Administration, 5600 Fishers Lane, Parklawn Building, Rockville, MD 20857, USA; John.Rossi@fda.hhs.gov
U2 - PMID: 19396676.
DO - 10.1080/15265160902788728
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DP - EBSCOhost
DB - rzh
ER -
TY - CASE
AU - Olszewska, Malgorzata
AU - Wu, John Z.
AU - Slowinska, Monika
AU - Rudnicka, Lidia
T1 - The 'PDA Nail'
JO - American Journal of Clinical Dermatology
JF - American Journal of Clinical Dermatology
Y1 - 2009/05//
VL - 10
IS - 3
M3 - Case Study
SP - 193
EP - 196
PB - Springer Science & Business Media B.V.
SN - 11750561
AB - All-in-one devices with mobile phone, web browser, and organizer are now owned by over 6 million people and their popularity is increasing. These devices are often called personal digital assistants (PDAs) or 'BlackBerry®" devices, after a popular brand name of these appliances. The use of PDAs is associated with exposure of distal thumbs and nails to repeated pressure with a frequency of up to a few thousand times per hour and several tens of thousands of times per day. We describe two cases of traumatic thumb nail dystrophy associated with using a PDA keyboard for several hours per day. Both patients developed median nail plate dystrophy after 4-8 months of habitual PDA use. One patient also developed thumb nail psoriasis and paronychia. All symptoms resolved a few months after discontinuing PDA use. Analysis of nail biomechanics, performed by using a finite element fingertip model, showed that maximal stress reaches approximately 3 MPa and appears near the root on the internal surface of the nail, while It reaches approximately 2 MPa and appears around one-third from the root on the outside surface. In conclusion, biomechanical stress resulting from overuse of PDAs may result in various types of nail dystrophy. We suggest the general term 'PDA nails' for these nail abnormalities. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Clinical Dermatology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NAILS (Anatomy) -- Diseases
KW - POCKET computers
KW - BLACKBERRY (Smartphone)
KW - DYSTROPHY
KW - PSORIASIS
KW - PARONYCHIA
N1 - Accession Number: 40830432; Olszewska, Malgorzata 1 Wu, John Z. 2 Slowinska, Monika 3 Rudnicka, Lidia 3,4; Email Address: lidiarudnicka@yahoo.com; Affiliation: 1: Department of Dermatology, Warsaw Medical University, Warsaw, Poland 2: National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA 3: Department of Dermatology CSK MSWiA, Warsaw, Poland 4: Faculty of Health Sciences, Warsaw Medical University, Warsaw, Poland; Source Info: 2009, Vol. 10 Issue 3, p193; Subject Term: NAILS (Anatomy) -- Diseases; Subject Term: POCKET computers; Subject Term: BLACKBERRY (Smartphone); Subject Term: DYSTROPHY; Subject Term: PSORIASIS; Subject Term: PARONYCHIA; Number of Pages: 4p; Illustrations: 4 Color Photographs, 1 Graph; Document Type: Case Study
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SangWoo Tak
AU - Davis, Rickie R.
AU - Calvert, Geoffrey M.
T1 - Exposure to Hazardous Workplace Noise and Use of Hearing Protection Devices Among US Workers—NHANES, 1999-2004.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/05//
VL - 52
IS - 5
M3 - Article
SP - 358
EP - 371
SN - 02713586
AB - The article offers information on a study analyzing the exposure of U.S. workers to hazardous workplace noise and the use of hearing protection devices. It presents the National Health and Nutrition Examination Survey (NHANES) conducted by the National Center for Health Statistics (NCHS) which was designed to assess the health and nutritional status of adults and children in the U.S. It discusses the occupational variables which affect the participants' hearing conditions which was classified into 45 industry categories by NCHS. Information on the results of the study conducted as well as the recommendations stating the need for a national framework for the prevention of occupational hearing loss are also presented.
KW - Health surveys
KW - Industrial workers
KW - Health & Nutrition Examination Survey
KW - Medical statistics
KW - Industrial noise
KW - United States
KW - industry
KW - national estimates
KW - national survey
KW - noise-induced hearing loss
KW - occupation
KW - surveillance
KW - National Center for Health Statistics (U.S.)
N1 - Accession Number: 39362417; SangWoo Tak 1; Email Address: stak@cdc.gov; Davis, Rickie R. 2; Calvert, Geoffrey M. 1; Affiliations: 1: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Issue Info: May2009, Vol. 52 Issue 5, p358; Subject Term: Health surveys; Subject Term: Industrial workers; Subject Term: Health & Nutrition Examination Survey; Subject Term: Medical statistics; Subject Term: Industrial noise; Subject: United States; Author-Supplied Keyword: industry; Author-Supplied Keyword: national estimates; Author-Supplied Keyword: national survey; Author-Supplied Keyword: noise-induced hearing loss; Author-Supplied Keyword: occupation; Author-Supplied Keyword: surveillance ; Company/Entity: National Center for Health Statistics (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 14p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1002/ajim.20690
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=39362417&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Myers, John R.
T1 - Prevalence of ROPS-Equipped Tractors on Minority Operated Farms in the US.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/05//
VL - 52
IS - 5
M3 - Article
SP - 408
EP - 418
SN - 02713586
AB - The article discusses the study on the prevalence of agricultural tractors equipped with Roll-over protective structures (ROP) on minority operated farms in the U.S. It says that the study used data from the National Institute for Occupational Safety and Health (NIOSH) Minority Farm Operator Occupational Injury Surveillance of Production Agriculture (M-OISPA) survey to assess the prevalence rates of ROPS from a random sample of minority farm operators in the country in 2003. The study showed that the prevalence rates of ROPS on minority farms to the prevalence rates of ROPS on all farms in the country.
KW - Farm management
KW - RESEARCH
KW - Rollover protective structures (Machinery)
KW - Tractors -- Equipment & supplies
KW - Small farms
KW - Farms
KW - Minority farmers
KW - Sampling (Statistics)
KW - United States
KW - farms
KW - odds ratio
KW - racial minorities
KW - ROPS
KW - tractors
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 39362421; Myers, John R. 1; Email Address: jrmyers@cdc.gov; Affiliations: 1: Division of Safety Research National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: May2009, Vol. 52 Issue 5, p408; Thesaurus Term: Farm management; Thesaurus Term: RESEARCH; Subject Term: Rollover protective structures (Machinery); Subject Term: Tractors -- Equipment & supplies; Subject Term: Small farms; Subject Term: Farms; Subject Term: Minority farmers; Subject Term: Sampling (Statistics); Subject: United States; Author-Supplied Keyword: farms; Author-Supplied Keyword: odds ratio; Author-Supplied Keyword: racial minorities; Author-Supplied Keyword: ROPS; Author-Supplied Keyword: tractors ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115116 Farm Management Services; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 11p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1002/ajim.20685
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105535973
T1 - More Work Is Needed to Protect Medical Residents From Fatigue and Potential Errors, IOM Report Finds.
AU - Clancy CM
Y1 - 2009/05//May/Jun2009
N1 - Accession Number: 105535973. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Fatigue -- Prevention and Control
KW - Institute of Medicine (U.S.)
KW - Internship and Residency -- Administration
KW - Safety
KW - Treatment Errors -- Prevention and Control
KW - Personnel Staffing and Scheduling -- Administration
KW - United States
SP - 259
EP - 261
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 24
IS - 3
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 19461069.
DO - 10.1177/1062860609334614
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fogeigren, Ben
AU - Shiming Yang
AU - Sharp, Ian C.
AU - Huckstep, Odaro J.
AU - Wenbin Ma
AU - Somponpun, S. J.
AU - Carlson, Edward C.
AU - Uyehara, Catherine F. T.
AU - Lozanoff, Scott
T1 - Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice.
JO - American Journal of Physiology: Renal Physiology
JF - American Journal of Physiology: Renal Physiology
Y1 - 2009/05//
VL - 65
IS - 5
M3 - Article
SP - F1166
EP - F1178
SN - 1931857X
AB - The Br/+ mutant mouse displays decreased embryological expression of the homeobox transcription factor Six2, resulting in hertitable renal hypoplasia. The purpose of this study was to characterize the renal physiological consequences of embryonic haploinsuffiency of Six2 by analyzing renal morphology and function in the adult Br heterozygous mutant. Adult Br/+ kidneys weighed 50% less than those from wild-type mice and displayed glomerulopathy. Stereological analysis of renal glomeruli showed that Br/+ kidneys had an average of 88% fewer glomeruli than +/+ kidneys, whereas individual glomeruli in Br/+ mice maintained an average volume increase of 180% compared with normal nephrons. Immunostaining revealed increased levels of endothelin-1 (ET-1), endothelin receptors A (ETA) and B (ETB), and Na-K-ATPase were present in the dilated renal tubules of mutant mice. Physiological features of chronic renal failure (CRF) including elevated mean arterial pressure, increased plasma creatinine, and dilute urine excretion were measured in Br/+ mutant mice. Electron microscopy of the Br/+ glomeruli revealed pathological alterations such as hypercellularity, extracellular matrix accumulation, and a thick irregular glomerular basement membrane. These results indicate that adult Br/+ mice suffer from CRF associated with reduced nephron number and renal hypoplasia, as well as glomerulopathy. Defects are associated with embryological deficiencies of Six2, suggesting that proper levels of this protein during nephrogenesis are critical for normal glomerular development and adult renal function. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Physiology: Renal Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPITHELIUM
KW - TRANSCRIPTION factors
KW - KIDNEY diseases
KW - CHRONIC kidney failure
KW - HOMEOBOX genes
KW - KIDNEY glomerulus
KW - Br mutant mouse
KW - glomerulus
N1 - Accession Number: 39467401; Fogeigren, Ben 1 Shiming Yang 1 Sharp, Ian C. 1 Huckstep, Odaro J. 1 Wenbin Ma 2 Somponpun, S. J. 3 Carlson, Edward C. 4 Uyehara, Catherine F. T. 3 Lozanoff, Scott 1; Email Address: lozanoff@hawaii.edu; Affiliation: 1: Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu 2: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Rockville, Maryland 3: Department of Clinical Investigation, Tripler Army Medical Center, Honolulu, Hawaii 4: Deparrment of Anatomy and Cell Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota; Source Info: May2009, Vol. 65 Issue 5, pF1166; Subject Term: EPITHELIUM; Subject Term: TRANSCRIPTION factors; Subject Term: KIDNEY diseases; Subject Term: CHRONIC kidney failure; Subject Term: HOMEOBOX genes; Subject Term: KIDNEY glomerulus; Author-Supplied Keyword: Br mutant mouse; Author-Supplied Keyword: glomerulus; Number of Pages: 13p; Illustrations: 2 Diagrams, 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1152/ajprenal.90550.2008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105457106
T1 - Effectiveness of vertical visual reference for reducing postural instability on inclined and compliant surfaces at elevation.
AU - Simeonov P
AU - Hsiao H
AU - Hendricks S
Y1 - 2009/05//
N1 - Accession Number: 105457106. Language: English. Entry Date: 20090605. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0261412.
KW - Balance, Postural -- Physiology
KW - Physical Stimulation
KW - Accidental Falls -- Prevention and Control
KW - Adult
KW - Biomechanics
KW - Facility Design and Construction
KW - Male
KW - Middle Age
KW - Occupational Health
KW - Orientation
KW - Psychomotor Performance
KW - Surface Properties
KW - Task Performance and Analysis
KW - West Virginia
KW - Human
SP - 353
EP - 361
JO - Applied Ergonomics
JF - Applied Ergonomics
JA - APPL ERGON
VL - 40
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0003-6870
AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA.
U2 - PMID: 19100527.
DO - 10.1016/j.apergo.2008.11.007
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Lin, Zhichao
AU - Wu, Zhongyu
T1 - Analysis of polonium-210 in food products and bioassay samples by isotope-dilution alpha spectrometry
JO - Applied Radiation & Isotopes
JF - Applied Radiation & Isotopes
Y1 - 2009/05//
VL - 67
IS - 5
M3 - Article
SP - 907
EP - 912
SN - 09698043
AB - Abstract: A rapid and reliable radiochemical method coupled with a simple and compact plating apparatus was developed, validated, and applied for the analysis of 210Po in variety of food products and bioassay samples. The method performance characteristics, including accuracy, precision, robustness, and specificity, were evaluated along with a detailed measurement uncertainty analysis. With high Po recovery, improved energy resolution, and effective removal of interfering elements by chromatographic extraction, the overall method accuracy was determined to be better than 5% with measurement precision of 10%, at 95% confidence level. [Copyright &y& Elsevier]
AB - Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLONIUM isotopes
KW - RADIOACTIVE contamination of food
KW - BIOLOGICAL assay
KW - DILUTION
KW - ALPHA ray spectrometry
KW - RADIOCHEMICAL analysis
KW - FOOD -- Analysis
KW - Alpha spectrometry
KW - Bioassay
KW - Food product
KW - Plating apparatus
KW - Polonium-210
KW - Radiochemical purification
N1 - Accession Number: 37347271; Lin, Zhichao; Email Address: zhichao.lin@fda.hhs.gov Wu, Zhongyu 1; Affiliation: 1: Winchester Engineering and Analytical Center, Food and Drug Administration, 109 Holton Street, Winchester, MA 01890, USA; Source Info: May2009, Vol. 67 Issue 5, p907; Subject Term: POLONIUM isotopes; Subject Term: RADIOACTIVE contamination of food; Subject Term: BIOLOGICAL assay; Subject Term: DILUTION; Subject Term: ALPHA ray spectrometry; Subject Term: RADIOCHEMICAL analysis; Subject Term: FOOD -- Analysis; Author-Supplied Keyword: Alpha spectrometry; Author-Supplied Keyword: Bioassay; Author-Supplied Keyword: Food product; Author-Supplied Keyword: Plating apparatus; Author-Supplied Keyword: Polonium-210; Author-Supplied Keyword: Radiochemical purification; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.apradiso.2009.01.055
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Crabtree, Mary B.
AU - Nga, Phan T.
AU - Miller, Barry R.
T1 - Isolation and characterization of a new mosquito flavivirus, Quang Binh virus, from Vietnam.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2009/05//
VL - 154
IS - 5
M3 - Report
SP - 857
EP - 860
SN - 03048608
AB - In recent years, a number of flaviviruses that replicate only in an arthropod host have been discovered and characterized. We describe here the isolation and characterization of a new mosquito-only flavivirus in this group. The virus was isolated from Culex tritaeniorhyncus mosquitoes collected in Vietnam in 2002 and was found to be genetically different from mosquito flaviviruses described previously. We propose the isolate be named Quang Binh virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVIVIRUSES
KW - MOSQUITOES as carriers of disease
KW - FLAVIVIRAL diseases
KW - ARTHROPOD vectors
KW - VIETNAM
N1 - Accession Number: 39142484; Crabtree, Mary B. 1; Email Address: meb3@cdc.gov Nga, Phan T. 2 Miller, Barry R. 1; Affiliation: 1: Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, 3150 Rampart Road, Fort Collins, CO 80521, USA 2: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Source Info: May2009, Vol. 154 Issue 5, p857; Subject Term: FLAVIVIRUSES; Subject Term: MOSQUITOES as carriers of disease; Subject Term: FLAVIVIRAL diseases; Subject Term: ARTHROPOD vectors; Subject Term: VIETNAM; Number of Pages: 4p; Illustrations: 1 Diagram, 2 Charts; Document Type: Report
L3 - 10.1007/s00705-009-0373-1
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - McCoy, J;
AU - Crosby, L;
T1 - Effect of a pharmacist managed alcohol abstinence clinic in reducing alcohol cravings
CT - Effect of a pharmacist managed alcohol abstinence clinic in reducing alcohol cravings
JO - ASHP Midyear Clinical Meeting
JF - ASHP Midyear Clinical Meeting
SP - 247
AD - Indian Hlth Serv Warm Springs Hlth & Wellness Ctr, POB 1209, 1270 Kot Num Rd, Warm Springs, OR 97761, USA Jeffrey.Mccoy@ihs.gov
N1 - Accession Number: 46-21394; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Pharmacy Practice
N2 - Abstract: Purpose: Alcoholism is a chronic disease that continues to significantly affect the health of Native Americans. In an effort to reduce this impact and improve the wellbeing of Native Americans, a pharmacist managed alcohol abstinence clinic has been implemented. The objective of this clinic is to enhance the recovery of Native Americans addicted to alcohol by reducing the mental and physical cravings associated with alcohol. This study is a medication utilization evaluation conducted six months after the implementation of this protocol. Methods: A clinical collaborative practice agreement has been implemented with alcohol addiction counseling and medication therapy as the primary interventions. Medication therapy consisted of baclofen, disulfiram, or naltrexone. Patients over the age of 18 with a positive CAGE screening for alcoholism, and who exhibited a desire to quit were allowed to enroll. Patients were excluded from the study and referred to their designated provider if: participation with counseling could not be verified, they were pregnant or breastfeeding, hepatic transaminases were greater than 3 times normal, creatinine clearance was less than 60 ml per minute, had or developed contraindications to medication therapy, or for any new medical conditions that arose that warranted further medical management. The following data was collected: patient demographics, penn alcohol craving (PAC) scale, duration of abstinence, number of patients that successfully achieved abstinence (quit drinking for at least 3 months), adherence to clinic protocol, number of days patients drank alcohol, and amount of alcohol consumed. All data was collected without patient identifiers and maintained confidentially. Population demographics and prospective outcomes were analyzed using basic descriptive statistics. Results: Eleven patients enrolled in the study and nine returned to the clinic for at least one follow up appointment. Of those nine patients, eight participants (88.9 percent) saw a reduction in their initial PAC scale upon conclusion of the medication utilization evaluation. The average decrease in their PAC scale scores were 6.4 (range -3 to 13). All nine reduced the amount of alcohol consumed per week and number of days they consumed alcohol. These patients all achieved sobriety upon conclusion of the study as well. On average patients were able to abstain from alcohol for 65 days (range 39 to 115 days) and two patients (18.2 percent) had successfully achieved abstinence by maintaining sobriety for three months. Conclusion: For Native Americans addicted to alcohol, a pharmacist managed clinic using pharmacological and behavioral interventions can assist in reducing alcohol cravings and consumption.
KW - ASHP meeting abstracts--pharmacists;
KW - Alcoholism--disease management;
KW - Pharmacists--ASHP meeting abstracts;
KW - Disease management--alcoholism;
KW - Practice Interest Areas--Automation/Informatics; meeting presentations;
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DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
T1 - Common Variation in Genes Related to Innate Immunity and Risk of Adult Glioma.
AU - Rajaraman, Preetha
AU - Brenner, Alma V.
AU - Butler, Mary Ann
AU - Wang, Sophia S.
AU - Pfeiffer, Ruth M.
AU - Ruder, Avima M.
AU - Linet, Martha S.
AU - Yeager, Meredith
AU - Zhaoming Wang
AU - Orr, Nick
AU - Fine, Howard A.
AU - Deukwoo Kwon
AU - Thomas, Gilles
AU - Rothman, Nathaniel
AU - Inskip, Peter D.
AU - Chanock, Stephen J.
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
Y1 - 2009/05//
VL - 18
IS - 5
SP - 1651
EP - 1658
SN - 10559965
N1 - Accession Number: 41341514; Author: Rajaraman, Preetha: 1 email: rajarama@mail.nih.gov. Author: Brenner, Alma V.: 1 Author: Butler, Mary Ann: 2 Author: Wang, Sophia S.: 1 Author: Pfeiffer, Ruth M.: 1 Author: Ruder, Avima M.: 2 Author: Linet, Martha S.: 1 Author: Yeager, Meredith: 3 Author: Zhaoming Wang: 3 Author: Orr, Nick: 3 Author: Fine, Howard A.: 4 Author: Deukwoo Kwon: 1 Author: Thomas, Gilles: 3 Author: Rothman, Nathaniel: 1 Author: Inskip, Peter D.: 1 Author: Chanock, Stephen J.: 3 ; Author Affiliation: 1 Division of Cancer Epidemiology and Genetics: 2 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Department of Health and Human Services, Cincinnati, Ohio: 3 Core Genotyping Facility, Advanced Technology Program, SAIC Frederick, Inc. MCI-Frederick, Frederick, Maryland: 4 Neuro-OncoIogy Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; No. of Pages: 8; Language: English; Publication Type: Article; Update Code: 20090611
N2 - The article offers an association study of 551 glioma cases and 865 matched controls of European ancestry to examine tag single nucleotide polymorphisms (SNP) in 148 genetic regions. It depicts an investigation restricted to glioblastoma which gained significant associations for the SELP, SERPINI1, and LY96 genetic regions. It determines a promising set of innate immunity-related genetic regions for further examination.
KW - GLIOMAS -- Research
KW - GENEALOGY
KW - GENETIC polymorphisms
KW - NATURAL immunity
KW - GENES
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Kannan, Meganathan
AU - Yadav, Birendra Kumar
AU - Ahmad, Firdos
AU - Biswas, Arijit
AU - Saxena, Renu
T1 - Modulation of clinical phenotype of Glanzmann's thrombasthenia by thrombogenic mutations
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
Y1 - 2009/05//
VL - 403
IS - 1/2
M3 - Article
SP - 156
EP - 158
SN - 00098981
AB - Abstract: Background: Glanzmann''s thrombasthenia (GT) is an autosomal recessive bleeding disorder which is due to a defect in platelet aggregation in response to multiple physiological agonists. It has been demonstrated that the clinical phenotype of various diseases inherited in a classic Mendelian fashion can be modulated by a series of factors, inherited as well as acquired. Methods: A total of 45 GT patients were screened for the thrombogenic polymorphisms, i.e., FV Leiden (R506Q), Prothrombin G20210A, MTHFR C677T and HPA-1 by PCR/RFLP. Results: MTHFR C677T heterozygous was seen in 6 patients, FV Leiden heterozygous in one and Prothrombin G20210A gene variant in none. HPA-1 was seen in 3 patients of whom 1 was homozygous and 2 were heterozygous. Conclusion: Thus the coinheritance of heterozygous FV Leiden alone or homozygous HPA 1b alone or the combined heterozygosity of MTHFR and HPA-1 were predicted to alter the clinical phenotype. Whereas the inheritance of heterozygous MTHFR alone or heterozygous HPA-1 alone did not altered the clinical phenotype significantly. Hence FV Leiden, MTHFR C677T polymorphism along with PLA-1 and homozygous HPA-1 were the probable ameliorating factor in GT mild phenotype. [Copyright &y& Elsevier]
AB - Copyright of Clinica Chimica Acta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL genetics
KW - HEMORRHAGIC diseases
KW - GENETIC disorders
KW - PROTHROMBIN
KW - MUTATION (Biology)
KW - MEDICAL screening
KW - HEMORRHAGE
KW - Clinical phenotype
KW - Glanzmann's thrombasthenia
KW - Modulation
KW - Thrombogenic mutations
N1 - Accession Number: 38322292; Kannan, Meganathan 1,2 Yadav, Birendra Kumar 1 Ahmad, Firdos 1 Biswas, Arijit 1 Saxena, Renu 1; Email Address: profrsaxena@gmail.com; Affiliation: 1: Department of Hematology, All India Institute of Medical Sciences, New Delhi, India 2: Division of Hematology, U.S. Food and Drug Administration, NIH campus, Bethesda, MD 20892, United States; Source Info: May2009, Vol. 403 Issue 1/2, p156; Subject Term: MEDICAL genetics; Subject Term: HEMORRHAGIC diseases; Subject Term: GENETIC disorders; Subject Term: PROTHROMBIN; Subject Term: MUTATION (Biology); Subject Term: MEDICAL screening; Subject Term: HEMORRHAGE; Author-Supplied Keyword: Clinical phenotype; Author-Supplied Keyword: Glanzmann's thrombasthenia; Author-Supplied Keyword: Modulation; Author-Supplied Keyword: Thrombogenic mutations; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 3p; Document Type: Article
L3 - 10.1016/j.cca.2009.02.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38322292&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105356809
T1 - Treatment choice between GnRH receptor agonists and antagonists for advanced prostate cancer.
AU - Ning Y
Y1 - 2009/05//2009 May
N1 - Accession Number: 105356809. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Men's Health; Oncologic Care. NLM UID: 101223547.
KW - Gonadorelin -- Antagonists and Inhibitors
KW - Oligopeptides -- Therapeutic Use
KW - Prostatic Neoplasms -- Drug Therapy
KW - Male
KW - Orchiectomy -- Methods
KW - Testosterone -- Metabolism
SP - 200
EP - 201
JO - Community Oncology
JF - Community Oncology
JA - COMMUNITY ONCOL
VL - 6
IS - 5
PB - Elsevier Science
SN - 1548-5315
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105356809&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105371257
T1 - Concurrent use of statins and amiodarone.
AU - Borders-Hemphill V
Y1 - 2009/05//2009 May
N1 - Accession Number: 105371257. Language: English. Entry Date: 20090807. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9013983.
KW - Amiodarone -- Adverse Effects
KW - Antiarrhythmia Agents -- Adverse Effects
KW - Antilipemic Agents -- Adverse Effects
KW - Rhabdomyolysis -- Chemically Induced
KW - Aged
KW - Antilipemic Agents -- Pharmacokinetics
KW - Drug Interactions
KW - Drug Monitoring
KW - Female
KW - Male
KW - Middle Age
KW - Prospective Studies
KW - Resource Databases
KW - Retrospective Design
KW - Human
SP - 372
EP - 379
JO - Consultant Pharmacist
JF - Consultant Pharmacist
JA - CONSULTANT PHARMACIST
VL - 24
IS - 5
CY - Alexandria, Virginia
PB - American Society of Consultant Pharmacists
SN - 0888-5109
AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Division of Epidemiology, Silver Spring, Maryland 20903, USA.
U2 - PMID: 19555146.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105371257&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Peters, John R.
AU - Hixon, Dena R.
AU - Conner, Dale P.
AU - Davit, Barbara M.
AU - Catterson, Debra M.
AU - Parise, Cecelia M.
T1 - Generic drugs – safe, effective, and affordable.
JO - Dermatologic Therapy
JF - Dermatologic Therapy
Y1 - 2009/05//
VL - 22
IS - 3
M3 - Article
SP - 229
EP - 240
PB - Wiley-Blackwell
SN - 13960296
AB - This article discusses the history and evolution of the process for generic drug evaluation and approval in the United States, with emphasis on locally acting dermatologic products. The requirements for in vivo bioequivalence (BE) testing and the statistical criteria for BE are discussed, and an example of a topical antifungal dermatologic product is used to demonstrate the BE determination for locally acting drugs. Other factors in the dispensing of prescription medications that are not within the Food and Drug Administration regulatory authority are also mentioned. [ABSTRACT FROM AUTHOR]
AB - Copyright of Dermatologic Therapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GENERIC drugs
KW - STATISTICS
KW - GENERIC drug substitution
KW - ANTIFUNGAL agents
KW - UNITED States
KW - bioequivalence
KW - FDA
KW - generic
KW - substitution
KW - topical
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 38802091; Peters, John R. 1 Hixon, Dena R. 1; Email Address: dena.hixon@fda.hhs.gov Conner, Dale P. 1 Davit, Barbara M. 1 Catterson, Debra M. 1 Parise, Cecelia M. 1; Affiliation: 1: Office of Generic Drugs, U.S. Food and Drug Administration, Rockville, Maryland; Source Info: May2009, Vol. 22 Issue 3, p229; Subject Term: GENERIC drugs; Subject Term: STATISTICS; Subject Term: GENERIC drug substitution; Subject Term: ANTIFUNGAL agents; Subject Term: UNITED States; Author-Supplied Keyword: bioequivalence; Author-Supplied Keyword: FDA; Author-Supplied Keyword: generic; Author-Supplied Keyword: substitution; Author-Supplied Keyword: topical; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 12p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1111/j.1529-8019.2009.01236.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38802091&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dang, Jiyoung M.
AU - Krause, David
AU - Felten, Richard P.
AU - Luke, Markham K.
T1 - Medical device regulation: what a practicing dermatologist should know.
JO - Dermatologic Therapy
JF - Dermatologic Therapy
Y1 - 2009/05//
VL - 22
IS - 3
M3 - Article
SP - 241
EP - 245
PB - Wiley-Blackwell
SN - 13960296
AB - The practicing dermatologist uses many medical devices during his or her day-to-day practice. The authors present a broad overview of how such medical devices are reviewed for safety and reasonable assurance of effectiveness, and evaluated for classification prior to marketing in the United States by the Food and Drug Administration. The specific example of dermal fillers as a class III medical device is discussed together with its regulatory ramifications. This article is written by staff currently employed at the Center for Devices and Radiological Health and should provide information useful to the practicing dermatologist. [ABSTRACT FROM AUTHOR]
AB - Copyright of Dermatologic Therapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DERMATOLOGISTS
KW - MEDICAL equipment
KW - MARKETING
KW - DERMATOLOGY
KW - CDRH
KW - dermal filler
KW - FDA
KW - medical device
KW - regulation
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 38802090; Dang, Jiyoung M. 1 Krause, David 1 Felten, Richard P. 1 Luke, Markham K. 1; Email Address: markham.luke@fda.hhs.gov; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, Office of Device Evaluation, Rockville, Maryland; Source Info: May2009, Vol. 22 Issue 3, p241; Subject Term: DERMATOLOGISTS; Subject Term: MEDICAL equipment; Subject Term: MARKETING; Subject Term: DERMATOLOGY; Author-Supplied Keyword: CDRH; Author-Supplied Keyword: dermal filler; Author-Supplied Keyword: FDA; Author-Supplied Keyword: medical device; Author-Supplied Keyword: regulation; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541613 Marketing Consulting Services; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 5p; Document Type: Article
L3 - 10.1111/j.1529-8019.2009.01237.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38802090&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lindstrom, Jill A.
T1 - Sources of drug information: FDA-approved labeling and other official FDA sources.
JO - Dermatologic Therapy
JF - Dermatologic Therapy
Y1 - 2009/05//
VL - 22
IS - 3
M3 - Article
SP - 246
EP - 256
PB - Wiley-Blackwell
SN - 13960296
AB - To protect the public health and facilitate the safe and effective use of prescription drugs, the Food and Drug Administration (FDA) disseminates information through drug labeling, communication of safety issues, and the archiving of scientific reviews. The content and format requirements for professional labeling were revised in 2006 to improve the accessibility and usability of the information. New or emerging safety information is communicated using the formats of public health advisories (PHAs), information for heath care professional sheets, and early communications about ongoing safety reviews. The FDA analyses of approved drug marketing applications and Advisory Committee transcripts are posted on the FDA Web site. Prescribers can utilize these resources to inform the care that they provide to patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Dermatologic Therapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - DRUGS
KW - PATIENTS
KW - MEDICAL care
KW - LABELING
KW - UNITED States
KW - Food and Drug Administration
KW - labeling
KW - safety
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 38802089; Lindstrom, Jill A. 1; Email Address: jill.lindstrom@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Silver Spring, Maryland; Source Info: May2009, Vol. 22 Issue 3, p246; Subject Term: PUBLIC health; Subject Term: DRUGS; Subject Term: PATIENTS; Subject Term: MEDICAL care; Subject Term: LABELING; Subject Term: UNITED States; Author-Supplied Keyword: Food and Drug Administration; Author-Supplied Keyword: labeling; Author-Supplied Keyword: safety; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Illustrations: 1 Color Photograph, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1529-8019.2009.01238.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38802089&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Reuter, Gábor
T1 - Bovine Kobuvirus in Europe.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/05//
VL - 15
IS - 5
M3 - Letter
SP - 822
EP - 823
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - A letter to the editor is presented regarding the detection of bovine kobuvirus in Europe.
KW - Viruses
KW - Letters to the editor
KW - Europe
N1 - Accession Number: 39749398; Reuter, Gábor 1; Email Address: reuter.gabor@baranya.antsz.hu; Affiliations: 1: Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary; Issue Info: May2009, Vol. 15 Issue 5, p822; Thesaurus Term: Viruses; Subject Term: Letters to the editor; Subject: Europe; Number of Pages: 2p; Illustrations: 1 Diagram; Document Type: Letter
L3 - 10.3201/eid1505.081427
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=39749398&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Chalmers, Rachel M.
AU - Robinson, Guy
AU - Elwin, Kristin
AU - Hadfield, Stephen J.
AU - Lihua Xiao
AU - Ryan, Una
AU - Modha, Deborah
AU - Mallaghan, Catherine
T1 - Cryptosporidium sp. Rabbit Genotype, a Newly Identified Human Pathogen.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/05//
VL - 15
IS - 5
M3 - Letter
SP - 829
EP - 830
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - The article presents a letter to the editor on cryptosporidiosis cased by cryptosporidium parvum of C. hominis.
KW - Cryptosporidiosis
KW - Letters to the editor
KW - Cryptosporidium parvum
N1 - Accession Number: 39749402; Chalmers, Rachel M. 1; Email Address: rachel.chalmers@nphs.wales.nhs.uk; Robinson, Guy 1; Elwin, Kristin 1; Hadfield, Stephen J. 1; Lihua Xiao 2; Ryan, Una 3; Modha, Deborah 4; Mallaghan, Catherine 4; Affiliations: 1: National Public Health Service for Wales, Swansea, Wales, UK; 2: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 3: Murdoch University, Murdoch, Western Australia, Australia; 4: Health Protection Agency East Midlands South, Leicester, UK; Issue Info: May2009, Vol. 15 Issue 5, p829; Thesaurus Term: Cryptosporidiosis; Subject Term: Letters to the editor; Subject Term: Cryptosporidium parvum; Number of Pages: 2p; Document Type: Letter
L3 - 10.3201/eid1505.081419
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=39749402&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105401864
T1 - Developing an international community of research.
AU - Grady PA
Y1 - 2009/05//2009 May-Jun
N1 - Accession Number: 105401864. Language: English. Entry Date: 20090911. Revision Date: 20150820. Publication Type: Journal Article; review. Journal Subset: Blind Peer Reviewed; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed. Special Interest: Evidence-Based Practice. NLM UID: 101190915.
KW - International Relations
KW - Nursing Practice, Evidence-Based
KW - Nursing Science
KW - Research, Nursing
KW - World Health
KW - Collaboration
KW - Congresses and Conferences
KW - European Union
KW - Health Care Delivery
KW - Intraprofessional Relations
KW - National Institute of Nursing Research (U.S.)
KW - Nurse Researchers
KW - Nursing Manpower
KW - Preventive Health Care
KW - Professional Development
KW - Research Support
KW - United States
SP - 149
EP - 155
JO - Enfermeria Clinica
JF - Enfermeria Clinica
JA - ENFERM CLIN
VL - 19
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1130-8621
AD - National Institute of Nursing Research, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA. gladstonee@mail.nih.gov
U2 - PMID: 19467894.
DO - 10.1016/j.enfcli.2009.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105401864&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105354794
T1 - Relationships between observational estimates and physical measurements of upper limb activity [corrected] [published erratum appears in ERGONOMICS 2009 Sep;52(9):1183].
AU - Lowe BD
AU - Krieg EF
Y1 - 2009/05//
N1 - Accession Number: 105354794. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; questionnaire/scale; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Instrumentation: Hand Activity Level Scale; Borg Category-Ratio Perceived Exertion (CR-10) Scale. NLM UID: 0373220.
KW - Clinical Assessment Tools
KW - Ergonomics -- Evaluation
KW - Instrument Validation
KW - Observational Methods
KW - Task Performance and Analysis -- Evaluation
KW - Upper Extremity -- Physiology
KW - Workload Measurement -- Methods
KW - Biophysical Instruments
KW - Body Weights and Measures
KW - Correlation Coefficient
KW - Descriptive Statistics
KW - Electromyography
KW - Equipment Reliability
KW - Exertion -- Evaluation
KW - Extension
KW - Flexion
KW - Goniometry
KW - Hand -- Physiology
KW - Internal Validity
KW - Intraclass Correlation Coefficient
KW - Kinematics -- Evaluation
KW - Linear Regression
KW - Motion Analysis Systems
KW - Ohio
KW - Scales
KW - Validation Studies
KW - Videorecording
KW - Visual Analog Scaling
KW - Wrist -- Physiology
KW - Human
SP - 569
EP - 583
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 52
IS - 5
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - This study examined the internal validity of observational-based ergonomic job analysis methods for assessing upper limb force exertion and repetitive motion. Six manual tasks were performed by multiple 'workers' while direct measurements were made to quantify force exertion and kinematics of the upper limb. Observational-based analyses of force and upper limb motion/repetition were conducted by 29 professional ergonomists. These analysts overestimated the magnitude of individual force exertions - temporal aspects of force exertion (duty cycle) were estimated more accurately. Estimates of the relative severity of repetitive motions among the jobs were accurate. Absolute counts of repetitive motions were less accurate. Modest correlations (r(2) = 0.28 to r(2) = 0.50) were observed between ratings of hand activity level and measured joint velocities. Ergonomic job analyses relying on systematic observation should be applied and interpreted with consideration given to the capabilities and limitations of analysts in estimating the physical risk factors. These findings are relevant to a better understanding of the internal validity of ergonomic job analysis methods based on systematic observation.
SN - 0014-0139
AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
U2 - PMID: 19424924.
DO - 10.1080/00140130802449682
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105354794&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - ABST
AU - Jacobson-Kram, David
T1 - S14: Use of transgenic mice in carcinogenicity hazard assessment: Is this the future?
JO - Experimental & Toxicologic Pathology
JF - Experimental & Toxicologic Pathology
Y1 - 2009/05//
VL - 61
IS - 3
M3 - Abstract
SP - 262
EP - 263
SN - 09402993
AB - The two-species rodent lifetime bioassay is still considered to be the gold standard for carcinogenicity assessment. This assay, which has hardly changed in the last quarter century, is protracted, expensive, utilizes many animals and often gives results which are of questionable relevance to human risk. A 1997 ICH guideline (S1B) permitted the use of alternative assays in place of a mouse two-year study. The alternative most often utilized by drug sponsors has been 6-month studies in transgenic mice. Since the guideline was finalized, FDA''s Center for Drug Evaluation and Research has received and reviewed 157 protocols for transgenic mouse carcinogenicity assays and reviewed results of 53 completed studies. The overwhelming numbers of studies have been negative. Approximately a quarter of the mouse protocols currently reviewed by CDER''s executive carcinogen assessment committee are for transgenic mice. While these assays are shorter in duration and use fewer animals, time from beginning range-finding studies to a final report on the definitive test is still a year or more. Transgenic mice are difficult to produce, expensive and results are still of uncertain relevance to humans. A number of different approaches are being explored that may result in faster, less expensive and more relevant cancer risk assessment studies. Empirically derived “signatures” representing changes in gene expression associated with exposure to known carcinogens is being studied as means to predict cancer risk. While these validation studies are currently being performed in rodents, similar technologies could eventually be used to monitor patients in clinical trials. [Copyright &y& Elsevier]
AB - Copyright of Experimental & Toxicologic Pathology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Transgenic animals
KW - Mice
KW - Transgenic mice
KW - TRAMP mice
N1 - Accession Number: 38319482; Jacobson-Kram, David 1; Affiliations: 1: Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA; Issue Info: May2009, Vol. 61 Issue 3, p262; Thesaurus Term: Transgenic animals; Thesaurus Term: Mice; Subject Term: Transgenic mice; Subject Term: TRAMP mice; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.etp.2009.02.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=38319482&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Han, Beom Seok
AU - Cho, Wan-Seob
AU - Lee, Hakyoung
AU - Nam, Ki Taek
AU - Park, Ki Dae
AU - Choi, Mina
AU - Kim, Seung Hee
AU - Jeong, Jayoung
AU - Jang, Dong Deuk
T1 - P05: Carcinogenicity study of 3-Monochloropropane-1,2-diol in Sprague-Dawley rats
JO - Experimental & Toxicologic Pathology
JF - Experimental & Toxicologic Pathology
Y1 - 2009/05//
VL - 61
IS - 3
M3 - Abstract
SP - 283
EP - 284
SN - 09402993
AB - 3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant which has been detected in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, we investigated the carcinogenicity of 3-MCPD in SD rats. Groups of 50 male and 50 female rats were exposed to drinking water containing 0, 25, 100, 400ppm 3-MCPD for 2 years. Body weights and water consumption of male and female rats given 400ppm were significantly lower than those of the controls. The incidences of renal tubule adenoma or carcinoma and Leydig cell tumor occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinoma and Leydig cell tumor were significantly increased in 400ppm males. Incidence of renal tubule adenoma had a positive trend in female rats, with the incidence being significant in 400ppm group. In conclusion, there was clear evidence of carcinogenic activity of 3-MCPD in male SD rats based on increased incidences of renal tubule carcinoma and Leydig cell tumor. There was some evidence of carcinogenic activity of 3-MCPD in female SD rats based on increased incidences of renal tubule adenoma. [Copyright &y& Elsevier]
AB - Copyright of Experimental & Toxicologic Pathology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Diseases
KW - Carcinogens
KW - Rats
KW - Cancer
KW - Cancer -- Study & teaching
N1 - Accession Number: 38319509; Han, Beom Seok 1; Cho, Wan-Seob 1; Lee, Hakyoung 1; Nam, Ki Taek 1; Park, Ki Dae 1; Choi, Mina 1; Kim, Seung Hee 1; Jeong, Jayoung 1; Jang, Dong Deuk 1; Affiliations: 1: Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea; Issue Info: May2009, Vol. 61 Issue 3, p283; Thesaurus Term: Diseases; Thesaurus Term: Carcinogens; Subject Term: Rats; Subject Term: Cancer; Subject Term: Cancer -- Study & teaching; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.etp.2009.02.042
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=38319509&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Hwang, Myungsil
AU - Yun, Eukyung
AU - Shin, Jae-Ho
AU - Choi, Hong Serck
AU - Kim, Ja Young
AU - Jang, Dong Deuk
AU - Yoo, Tae Moo
T1 - P12: Benchmark dose for 3-monochloro-propane-1,2-diol (3-MCPD) in rat 2-year study
JO - Experimental & Toxicologic Pathology
JF - Experimental & Toxicologic Pathology
Y1 - 2009/05//
VL - 61
IS - 3
M3 - Abstract
SP - 287
EP - 287
SN - 09402993
AB - Chronic exposure guideline levels for the public are generally based on doses that produce no effects, following a NOAEL/LOAEL approach. Benchmark dose (BMD) approach devised by Crump (1982) may use to determine critical effect dose that are more or less conservative than the NOAEL/LOAEL approach. In this study, the use of the BMD as an alternative to a NOAEL approach was investigated as a mean to improve current risk assessment values of 3-monochloro-propane-1,2-diol (3-MCPD). We reviewed for the critical toxicological endpoints of 3-MCPD, namely nephropathy, tubular hyperplasia and tubule adenoma identified from the two available critical studies. Using the USEPA BMD software, considering available dichotomous models, we calculated BMDs of 3-MCPD, and their lower confidence limits (BMDLs) at response levels of 10%. The BMDs and BMDLs for the three end points were estimated using the Weibull, Probit, Linear, and Log-logistic models for each end point. All models passed the x 2 test statistics (p<0.1) for all the toxicity endpoints tested. The Log-logistic model provided a reasonable fit to all of the data sets. A Benchmark response (BMR) of 10% extra risk was chosen and the Akaike''s information criterion (AIC) was used in selecting the appropriate model. Based on the Log-logistic model, the BMDL estimates derived were found to be slightly higher than NOAEL for same endpoint but never exceed the LOAEL, indicating a reasonable association of the BMDL10 with the NOAEL. The BMD and BMDL for tubular hyperplasia, the most critical effect associated with 3-MCPD exposure, were 0.94 and 0.68mg/kg/day, respectively. This value will be used in the eventual determination of Tolerable Daily Dose (TDI) for 3-MCPD. This study has provided evidence that the BMD approach is a useful tool in reducing uncertainty in determination of an experimental threshold for adverse effects and improving the risk assessment for contaminants in food. This is an abstract of a proposed presentation and doses not reflect Korea Food and Drug Administration (KFDA) policy. Further studies are necessary to confirm whether proposed BMDL should be suggested in determination of the limit guidance level in KFDA. [Copyright &y& Elsevier]
AB - Copyright of Experimental & Toxicologic Pathology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Risk
KW - Management
KW - Insurance
KW - Self-insurance
N1 - Accession Number: 38319516; Hwang, Myungsil 1; Yun, Eukyung 1; Shin, Jae-Ho 1; Choi, Hong Serck 1; Kim, Ja Young 1; Jang, Dong Deuk 1; Yoo, Tae Moo 1; Affiliations: 1: Risk Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Issue Info: May2009, Vol. 61 Issue 3, p287; Subject Term: Risk; Subject Term: Management; Subject Term: Insurance; Subject Term: Self-insurance; NAICS/Industry Codes: 524292 Third Party Administration of Insurance and Pension Funds; NAICS/Industry Codes: 524298 All Other Insurance Related Activities; NAICS/Industry Codes: 525190 Other Insurance Funds; NAICS/Industry Codes: 526989 All other miscellaneous funds and financial vehicles; NAICS/Industry Codes: 524299 All other insurance related activities; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.etp.2009.02.049
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=38319516&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fisher, William H.
AU - Geller, Jeffrey L.
AU - Pandiani, John A.
T1 - The Changing Role Of The State Psychiatric Hospital.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/05//May/Jun2009
VL - 28
IS - 3
M3 - Article
SP - 676
EP - 684
SN - 02782715
AB - State hospitals were once the most prominent components of U.S. public mental health systems. But a major focus of mental health policy over the past fifty years has been to close these facilities. These efforts led to a 95 percent reduction in the country's state hospital population. However, more than 200 state hospitals remain open, serving a declining but challenging patient population. Using national and state-level data, this paper discusses the contemporary public mental hospital, the forces shaping its use, the challenges it faces, and its possible future role in the larger mental health system. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health policy
KW - PSYCHIATRIC hospitals
KW - HEALTH services administration
KW - MENTAL illness -- Treatment
KW - HOSPITAL patients
KW - MEDICAL care -- United States
KW - EXPERIMENTAL design
KW - PSYCHOLOGY
KW - UNITED States
N1 - Accession Number: 39761767; Fisher, William H. 1,2; Email Address: Bill.Fisher@Umassmed.edu Geller, Jeffrey L. 3 Pandiani, John A.; Affiliation: 1: Professor of Psychiatry, University of Massachusetts Medical School, Worcester 2: Associate Director, Center for Mental Health Services Research,University of Massachusetts Medical School, Worcester 3: Professor of Psychiatry, UMass Medical School; Source Info: May/Jun2009, Vol. 28 Issue 3, p676; Subject Term: MENTAL health policy; Subject Term: PSYCHIATRIC hospitals; Subject Term: HEALTH services administration; Subject Term: MENTAL illness -- Treatment; Subject Term: HOSPITAL patients; Subject Term: MEDICAL care -- United States; Subject Term: EXPERIMENTAL design; Subject Term: PSYCHOLOGY; Subject Term: UNITED States; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 623210 Residential Intellectual and Developmental Disability Facilities; Number of Pages: 9p; Document Type: Article
L3 - 10.1377/hlthaff.28.3.676
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39761767&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zuvekas, Samuel H.
AU - Meyerhoefer, Chad D.
T1 - State Variations In The Out-Of-Pocket Spending Burden For Outpatient Mental Health Treatment.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/05//May/Jun2009
VL - 28
IS - 3
M3 - Article
SP - 713
EP - 722
SN - 02782715
AB - We examine the potential of mental health/substance abuse (MH/SA) parity laws to reduce the out-of-pocket spending burden for outpatient treatment at the state level by exploring cross-state variations and their causes, as well as the provisions of MH/SA parity laws. We find modest (yet important) variation in out-of-pocket burden across states overall, but—because prescription medications account for two-thirds of out-of-pocket spending and are generally beyond the scope of recently enacted federal parity laws—evidence suggests that those laws will do little to reduce the observed burden or its variation. Other policy measures, designed to expand and improve health insurance coverage or reduce racial/ethnic disparities, could have a more profound impact. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL health policy
KW - EQUAL rights
KW - MENTAL illness -- Treatment
KW - MEDICAL care costs
KW - SUBSTANCE abuse
KW - HEALTH insurance
KW - MEDICAL care -- United States
KW - EMPIRICAL research
KW - UNITED States
N1 - Accession Number: 39761771; Zuvekas, Samuel H. 1; Email Address: samuel.zuvekas@ahrq.hhs.gov Meyerhoefer, Chad D. 2; Affiliation: 1: Senior Economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 2: Assistant Professor, Department of Economics, Lehigh University, Bethlehem, Pennsylvania; Source Info: May/Jun2009, Vol. 28 Issue 3, p713; Subject Term: MENTAL health policy; Subject Term: EQUAL rights; Subject Term: MENTAL illness -- Treatment; Subject Term: MEDICAL care costs; Subject Term: SUBSTANCE abuse; Subject Term: HEALTH insurance; Subject Term: MEDICAL care -- United States; Subject Term: EMPIRICAL research; Subject Term: UNITED States; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 623220 Residential Mental Health and Substance Abuse Facilities; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1377/hlthaff.28.3.713
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39761771&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donohue, Julie M.
AU - Huskamp, Haiden A.
AU - Zuvekas, Samuel H.
T1 - Dual Eligibles With Mental Disorders And Medicare Part D: How Are They Faring?
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/05//May/Jun2009
VL - 28
IS - 3
M3 - Article
SP - 746
EP - 759
SN - 02782715
AB - In 2006, six million beneficiaries who were eligible for both Medicare and Medicaid switched from Medicaid to Medicare Part D for coverage of their prescription drugs. This change led to an expanded role for Medicare in financing psychotropic medications for dual eligibles. A reduction in the number of plans serving these beneficiaries and an increase in utilization restrictions for some psychotropics since 2006 raise concerns about access to medications for dual eligibles with mental disorders and point to potential problems with adverse selection. To improve access for this population, Medicare might consider changes to its enrollment and risk-sharing systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MENTAL illness -- Treatment
KW - PSYCHIATRIC drugs
KW - RISK management in business
KW - MEDICARE
KW - HEALTH insurance -- United States
KW - MEDICAID beneficiaries
KW - PATHOLOGICAL psychology
KW - EXPERIMENTAL design
KW - UNITED States
N1 - Accession Number: 39761775; Donohue, Julie M. 1; Email Address: jdonohue@pitt.edu Huskamp, Haiden A. 2 Zuvekas, Samuel H. 3; Affiliation: 1: Assistant Professor, Health Policy and Management, University of Pittsburgh Graduate School of Public Health 2: Associate Professor of Health Care Policy, Harvard Medical School, Boston, Massachusetts 3: Senior Economist, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: May/Jun2009, Vol. 28 Issue 3, p746; Subject Term: MENTAL illness -- Treatment; Subject Term: PSYCHIATRIC drugs; Subject Term: RISK management in business; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: MEDICAID beneficiaries; Subject Term: PATHOLOGICAL psychology; Subject Term: EXPERIMENTAL design; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 14p; Document Type: Article
L3 - 10.1377/hlthaff.28.3.746
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39761775&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bernard, Didem M.
AU - Banthin, Jessica S.
AU - Encinosa, William E.
T1 - Wealth, Income, And The Affordability Of Health Insurance.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/05//May/Jun2009
VL - 28
IS - 3
M3 - Article
SP - 887
EP - 896
SN - 02782715
AB - There have been debates over how many uninsured people can afford insurance but refuse to purchase it. Examining the difference in asset holdings between the privately insured and the uninsured, we found that the difference in purchasing power is not fully revealed by income comparisons. Median income among the privately insured is 2.9 times that of the uninsured, but median wealth among those with private insurance is 23.2 times that of the uninsured. Our results suggest that assets are an important determinant of effective affordability, undermining the notion that many people are uninsured by choice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - MEDICAL savings accounts
KW - INCOME
KW - WEALTH
KW - MEDICALLY uninsured persons
KW - PURCHASING power
KW - EXPERIMENTAL design
N1 - Accession Number: 39761794; Bernard, Didem M. 1; Email Address: didem.bernard@ahrq.hhs.gov Banthin, Jessica S. 1 Encinosa, William E. 1; Affiliation: 1: Agency for Healthcare Research and Quality (AHRQ),Rockville, Maryland; Source Info: May/Jun2009, Vol. 28 Issue 3, p887; Subject Term: HEALTH insurance; Subject Term: MEDICAL savings accounts; Subject Term: INCOME; Subject Term: WEALTH; Subject Term: MEDICALLY uninsured persons; Subject Term: PURCHASING power; Subject Term: EXPERIMENTAL design; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; Number of Pages: 10p; Document Type: Article
L3 - 10.1377/hlthaff.28.3.887
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39761794&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pronovost, Peter J.
AU - Goeschel, Christine A.
AU - Olsen, Kyle L.
AU - Pham, Julius C.
AU - Miller, Marlene R.
AU - Berenholtz, Sean M.
AU - Sexton, J. Bryan
AU - Marsteller, Jill A.
AU - Morlock, Laura L.
AU - Wu, Albert W.
AU - Loeb, Jerod M.
AU - Clancy, Carolyn M.
T1 - Reducing Health Care Hazards: Lessons From The Commercial Aviation Safety Team.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/05//May/Jun2009
VL - 28
IS - 3
M3 - Article
SP - w479
EP - w489
SN - 02782715
AB - The movement to improve quality of care and patient safety has grown, but examples of measurable and sustained progress are rare. The slow progress made in health care contrasts with the success of aviation safety. After a tragic 1995 plane crash, the aviation industry and government created the Commercial Aviation Safety Team to reduce fatal accidents. This public-private partnership of safety officials and technical experts is responsible for the decreased average rate of fatal aviation accidents. We propose a similar partnership in the health care community to coordinate national efforts and move patient safety and quality forward. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care -- Quality control
KW - PROGRESS
KW - AERONAUTICS -- Safety measures
KW - AIRCRAFT accidents
KW - AIRLINE industry
KW - GOVERNMENT policy
KW - PARTNERSHIP (Business)
N1 - Accession Number: 39761820; Pronovost, Peter J. 1; Email Address: ppronovo@jhmi.edu Goeschel, Christine A. 2 Olsen, Kyle L. Pham, Julius C. 3 Miller, Marlene R. 4,5 Berenholtz, Sean M. 6 Sexton, J. Bryan 7 Marsteller, Jill A. 8 Morlock, Laura L. 9 Wu, Albert W. 9 Loeb, Jerod M. 10 Clancy, Carolyn M. 11; Affiliation: 1: Professor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 2: Director, Quality and Patient Safety Initiatives, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 3: Assistant Professor, Emergency Medicine, Johns Hopkins 4: Associate Professor , Department of Pediatrics, Children's Center, Johns Hopkins 5: Vice Chair, Quality and Safety Initiatives, Children's Center, Johns Hopkins 6: Associate Professor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins 7: Assistant Professor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins 8: Assistant Professor, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health 9: Professor, Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health 10: Executive Vice President for Research, Joint Commission, Oakbrook Terrace, Illinois 11: Director, Agency for Healthcare Research and Quality, Rockville,Maryland; Source Info: May/Jun2009, Vol. 28 Issue 3, pw479; Subject Term: MEDICAL care -- Quality control; Subject Term: PROGRESS; Subject Term: AERONAUTICS -- Safety measures; Subject Term: AIRCRAFT accidents; Subject Term: AIRLINE industry; Subject Term: GOVERNMENT policy; Subject Term: PARTNERSHIP (Business); NAICS/Industry Codes: 481110 Scheduled air transportation; NAICS/Industry Codes: 481111 Scheduled Passenger Air Transportation; Number of Pages: 11p; Document Type: Article
L3 - 10.1377/hlthaff.28.3.w479
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39761820&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105532943
T1 - The changing role of the state psychiatric hospital.
AU - Fisher WH
AU - Geller JL
AU - Pandiani JA
Y1 - 2009/05//May/Jun2009
N1 - Accession Number: 105532943. Language: English. Entry Date: 20090619. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 8303128.
KW - Community Role
KW - Hospitals, Psychiatric -- History
KW - Hospitals, Public
KW - Mental Disorders, Chronic -- Epidemiology -- United States
KW - Mental Health Services -- Trends
KW - Budgets
KW - Case Management
KW - Forensic Psychiatry
KW - Health Care Delivery, Integrated
KW - Health Services Needs and Demand
KW - Hospitals, Community
KW - Involuntary Commitment
KW - Mentally Ill Offenders
KW - Organizational Restructuring
KW - Patient Classification
KW - Private Sector
KW - Reimbursement Mechanisms
KW - Sex Offenders
KW - United States
KW - Vulnerability
SP - 676
EP - 684
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
IS - 3
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - State hospitals were once the most prominent components of U.S. public mental health systems. But a major focus of mental health policy over the past fifty years has been to close these facilities. These efforts led to a 95 percent reduction in the country's state hospital population. However, more than 200 state hospitals remain open, serving a declining but challenging patient population. Using national and state-level data, this paper discusses the contemporary public mental hospital, the forces shaping its use, the challenges it faces, and its possible future role in the larger mental health system.
SN - 0278-2715
AD - Center for Mental Health Services Research, University of Massachusetts Medical School, in Worcester, USA. Bill.Fisher@Umassmed.edu
U2 - PMID: 19414875.
DO - 10.1377/hlthaff.28.3.676
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105532943&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105532948
T1 - State variations in the out-of-pocket spending burden for outpatient mental health treatment.
AU - Zuvekas SH
AU - Meyerhoefer CD
Y1 - 2009/05//May/Jun2009
N1 - Accession Number: 105532948. Language: English. Entry Date: 20090619. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 8303128.
KW - Geographic Factors
KW - Health Care Costs
KW - Mental Health Services
KW - Outpatient Service
KW - Comparative Studies
KW - Costs and Cost Analysis
KW - Demography
KW - Drugs, Generic -- Economics
KW - Health Policy
KW - Health Services Accessibility
KW - Health Status
KW - Insurance, Health -- Legislation and Jurisprudence -- United States
KW - Medically Uninsured
KW - Mental Disorders -- Therapy
KW - Outpatients
KW - Panel Studies -- United States
KW - Psychotropic Drugs -- Economics
KW - Secondary Analysis
KW - Substance Abuse -- Therapy
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - Variance Analysis
KW - Human
SP - 713
EP - 722
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
IS - 3
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - We examine the potential of mental health/substance abuse (MH/SA) parity laws to reduce the out-of-pocket spending burden for outpatient treatment at the state level by exploring cross-state variations and their causes, as well as the provisions of MH/SA parity laws. We find modest (yet important) variation in out-of-pocket burden across states overall, but-because prescription medications account for two-thirds of out-of-pocket spending and are generally beyond the scope of recently enacted federal parity laws-evidence suggests that those laws will do little to reduce the observed burden or its variation. Other policy measures, designed to expand and improve health insurance coverage or reduce racial/ethnic disparities, could have a more profound impact.
SN - 0278-2715
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, in Rockville, Maryland, USA. samuel.zuvekas@ahrq.hhs.gov
U2 - PMID: 19414879.
DO - 10.1377/hlthaff.28.3.713
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105532948&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105532971
T1 - Wealth, income, and the affordability of health insurance.
AU - Bernard DM
AU - Banthin JS
AU - Encinosa WE
Y1 - 2009/05//May/Jun2009
N1 - Accession Number: 105532971. Language: English. Entry Date: 20090619. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Assets
KW - Income
KW - Insurance, Health -- Economics
KW - Medically Uninsured
KW - Comparative Studies
KW - Correlational Studies
KW - Decision Making
KW - Descriptive Statistics
KW - Employer-Employee Relations
KW - Family
KW - Models, Statistical
KW - Multivariate Analysis
KW - Panel Studies -- United States
KW - Secondary Analysis
KW - United States
KW - United States Agency for Healthcare Research and Quality
KW - Human
SP - 887
EP - 896
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
IS - 3
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - There have been debates over how many uninsured people can afford insurance but refuse to purchase it. Examining the difference in asset holdings between the privately insured and the uninsured, we found that the difference in purchasing power is not fully revealed by income comparisons. Median income among the privately insured is 2.9 times that of the uninsured, but median wealth among those with private insurance is 23.2 times that of the uninsured. Our results suggest that assets are an important determinant of effective affordability, undermining the notion that many people are uninsured by choice.
SN - 0278-2715
AD - Agency for Healthcare Research and Quality (AHRQ) in Rockville, Maryland, USA. didem.bernard@ahrq.hhs.gov
U2 - PMID: 19414902.
DO - 10.1377/hlthaff.28.3.887
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105532971&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ebrahim, Shahul H.
AU - Anderson, John E.
AU - Correa-de-Araujo, Rosaly
AU - Posner, Samuel F.
AU - Atrash, Hani K.
T1 - Overcoming social and health inequalities among U.S. women of reproductive age—Challenges to the nation's health in the 21st century
JO - Health Policy
JF - Health Policy
Y1 - 2009/05//
VL - 90
IS - 2/3
M3 - Article
SP - 196
EP - 205
SN - 01688510
AB - Abstract: Objective: To frame the discussion of the nation''s health within the context of maternal and child health. Methods: We used national data or estimates to assess the burden of 46 determinants. Results: During 2002–2004, U.S. women of reproductive age experienced significant challenges from macrosocial determinants, to health care access, and to their individual health preservation. Two-thirds of women do not consume recommended levels of fruits and vegetables. Overall, 29% experienced income poverty, 16.3% were uninsured. About one in four women of reproductive age lived with poor social capital. Compared with white women of reproductive age, non-white women reported higher levels of dissatisfaction with the health care system and race-related discrimination. Among all U.S. women, chronic diseases contributed to the top nine leading causes of disability adjusted life years. About one-third of women had no prophylactic dental visits in the past year, or consumed alcohol at harmful levels and smoked tobacco. One in three women who had a child born recently did not breast feed their babies. Demographics of women who are at increased risk for the above indicators predominate among the socioeconomically disadvantaged. Conclusions: At least three-fourths of the U.S. women of reproductive age were at risk for poor health of their own and their offspring. Social intermediation and health policy changes are needed to increase the benefits of available health and social sector interventions to women and thereby to their offspring. [Copyright &y& Elsevier]
AB - Copyright of Health Policy is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care
KW - EQUALITY -- United States
KW - WOMEN -- Health -- United States
KW - AGE factors in human reproduction
KW - MACROSOCIOLOGY
KW - PUBLIC health -- United States
KW - MOTHERS -- Health
KW - CHILDREN -- Health
KW - HEALTH services accessibility -- United States
KW - UNITED States
KW - Children
KW - Macrosocial determinants
KW - Pregnancy
KW - United States
KW - Women
N1 - Accession Number: 37572435; Ebrahim, Shahul H. 1,2; Email Address: sebrahim@cdc.gov; Anderson, John E. 1,2; Correa-de-Araujo, Rosaly 2,3; Posner, Samuel F. 1,2; Atrash, Hani K. 1,2; Affiliations: 1: Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: US Department of Health and Human Services, USA; 3: Agency for Healthcare Research and Quality, Rockville, MD, USA; Issue Info: May2009, Vol. 90 Issue 2/3, p196; Thesaurus Term: MEDICAL care; Subject Term: EQUALITY -- United States; Subject Term: WOMEN -- Health -- United States; Subject Term: AGE factors in human reproduction; Subject Term: MACROSOCIOLOGY; Subject Term: PUBLIC health -- United States; Subject Term: MOTHERS -- Health; Subject Term: CHILDREN -- Health; Subject Term: HEALTH services accessibility -- United States; Subject: UNITED States; Author-Supplied Keyword: Children; Author-Supplied Keyword: Macrosocial determinants; Author-Supplied Keyword: Pregnancy; Author-Supplied Keyword: United States; Author-Supplied Keyword: Women; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.healthpol.2008.09.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=37572435&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105537134
T1 - HomeNet: ensuring patient safety with medical device use in the home.
AU - Kaufman D
AU - Weick-Brady M
Y1 - 2009/05//2009 May
N1 - Accession Number: 105537134. Language: English. Entry Date: 20090626. Revision Date: 20150711. Publication Type: Journal Article; pictorial; tables/charts. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Home Health Care; Informatics; Patient Safety. NLM UID: 8403379.
KW - Equipment Safety
KW - Home Care Equipment and Supplies
KW - World Wide Web
KW - Adverse Health Care Event
KW - Collaboration
KW - Consumers
KW - Corporations
KW - Feedback
KW - Home Care Equipment and Supplies -- Education
KW - Home Health Agencies
KW - Home Nursing, Professional
KW - Home Safety
KW - Patient Safety
KW - United States Food and Drug Administration
KW - Vendor Relations
KW - Voluntary Reporting
SP - 300
EP - 307
JO - Home Healthcare Nurse
JF - Home Healthcare Nurse
JA - HOME HEALTHC NURSE
VL - 27
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0884-741X
AD - Office of Surveillance and Biometrics, Food and Drug Administration Center for Devices and Radiological Health, Rockville, Maryland, USA. diana.kaufman@fda.hhs.gov
U2 - PMID: 19448498.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Doney, Brent
AU - Greskevitch, Mark
AU - Groce, Dennis
AU - Syamlal, Girija
AU - Ki Moon Bang
T1 - Respirator Use and Practices in Instruments and Related Products Manufacturing Establishments: Results of a National Survey of Private Sector Employers.
JO - Instrumentation Science & Technology
JF - Instrumentation Science & Technology
Y1 - 2009/05//May/Jun2009
VL - 37
IS - 3
M3 - Article
SP - 359
EP - 365
PB - Taylor & Francis Ltd
SN - 10739149
AB - In 2001, the Survey of Respirator Use and Practices gathered information on respirator use from 40,002 private U.S. establishments including the types of respirators used by workers, assessment of medical fitness to wear respirators, types of respirator fit tests, and presence of substances that prompted respirator use. Of respirator-using Instruments Manufacturing establishments, 22% did not provide training regarding the need, use, limitations, and capabilities of respirators; 37% did not provide assessment for medical fitness to wear respirators or didn't know if such an assessment was conducted; and 68% had three or more indicators of a potentially inadequate respiratory protection program. [ABSTRACT FROM AUTHOR]
AB - Copyright of Instrumentation Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESPIRATORS (Medical equipment)
KW - BREATHING apparatus
KW - BUSINESS enterprises -- United States
KW - INDUSTRIAL workers
KW - PRIVATE sector
KW - UNITED States
KW - Questionnaires
KW - Respirators
KW - Respiratory system disorders
KW - Silica dusts
KW - Worker health
N1 - Accession Number: 37379588; Doney, Brent 1; Email Address: bdoney@cdc.gov Greskevitch, Mark 1 Groce, Dennis 2 Syamlal, Girija 1 Ki Moon Bang 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Division of Respiratory Disease Studies, Morgantown, WV, USA 2: EG&G Technical Services, Inc., Pittsburgh, PA; Source Info: May/Jun2009, Vol. 37 Issue 3, p359; Subject Term: RESPIRATORS (Medical equipment); Subject Term: BREATHING apparatus; Subject Term: BUSINESS enterprises -- United States; Subject Term: INDUSTRIAL workers; Subject Term: PRIVATE sector; Subject Term: UNITED States; Author-Supplied Keyword: Questionnaires; Author-Supplied Keyword: Respirators; Author-Supplied Keyword: Respiratory system disorders; Author-Supplied Keyword: Silica dusts; Author-Supplied Keyword: Worker health; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1080/10739140902832063
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37379588&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thakur, S.
AU - White, D. G.
AU - McDermott, P. F.
AU - Zhao, S.
AU - Kroft, B.
AU - Gebreyes, W.
AU - Abbott, J.
AU - Cullen, P.
AU - English, L.
AU - Carter, P.
AU - Harbottle, H.
T1 - Genotyping of Campylobacter coli isolated from humans and retail meats using multilocus sequence typing and pulsed-field gel electrophoresis.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2009/05//
VL - 106
IS - 5
M3 - Article
SP - 1722
EP - 1733
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: To determine the antimicrobial resistant profiles and clonality of Campylobacter coli isolated from clinically ill humans and retail meats. Methods and Results: A total of 98 C. coli isolates (20 from humans and 78 from retail meats) were phenotypically characterized. Antimicrobial susceptibility testing was done using agar dilution method for ciprofloxacin, gentamicin, erythromycin and doxycycline. Seventy C. coli isolates including humans ( n = 20) and retail meats ( n = 50) were genotyped by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Resistance to ciprofloxacin was found in 29% and 15% of isolates from retail meats and humans. We observed 61 PFGE profiles using two enzymes ( SmaI, KpnI) with an Index of discrimination of 0·99, whereas MLST generated 37 sequence types. Two clonal complexes were identified with 58 (82%) C. coli isolates clustered in the ST-828 complex. Conclusions: Resistance to ciprofloxacin and erythromycin was identified in C. coli obtained from retail meats and ill humans. PFGE typing of C. coli isolates was more discriminatory than MLST. Grouping of C. coli isolates (82%) by MLST in ST-828 clonal complex indicates a common ancestry. Significance and Impact of the Study: A high frequency of resistance found to ciprofloxacin and erythromycin is concerning from food safety perspective. PFGE using single or double restriction enzymes was found to be more discriminatory than MLST for genotyping C. coli. Overall, the C. coli populations recovered from humans and retail meats were genotypically diverse. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genotype-environment interaction
KW - Campylobacter infections
KW - Anti-infective agents
KW - Gel electrophoresis
KW - Ciprofloxacin
KW - Gentamicin
KW - Erythromycin
KW - antimicrobial resistance
KW - Campylobacter coli
KW - humans
KW - multilocus sequence typing
KW - pulsed-field gel electrophoresis
KW - pulsedfield gel electrophoresis
KW - retail meats
N1 - Accession Number: 37320599; Thakur, S. 1; Email Address: sidthakur@ncsu.edu; White, D. G. 2; McDermott, P. F. 2; Zhao, S. 2; Kroft, B. 3; Gebreyes, W. 4; Abbott, J. 2; Cullen, P. 5; English, L. 2; Carter, P. 2; Harbottle, H. 2; Affiliations: 1: Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; 2: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U. S. Food and Drug Administration, Laurel, MD, USA; 3: Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA; 4: Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Columbus, OH, USA; 5: Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector borne, and Enteric Diseases, CCID/CDC, Atlanta , GA, USA; Issue Info: May2009, Vol. 106 Issue 5, p1722; Thesaurus Term: Genotype-environment interaction; Thesaurus Term: Campylobacter infections; Thesaurus Term: Anti-infective agents; Subject Term: Gel electrophoresis; Subject Term: Ciprofloxacin; Subject Term: Gentamicin; Subject Term: Erythromycin; Author-Supplied Keyword: antimicrobial resistance; Author-Supplied Keyword: Campylobacter coli; Author-Supplied Keyword: humans; Author-Supplied Keyword: multilocus sequence typing; Author-Supplied Keyword: pulsed-field gel electrophoresis; Author-Supplied Keyword: pulsedfield gel electrophoresis; Author-Supplied Keyword: retail meats; Number of Pages: 12p; Illustrations: 2 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1111/j.1365-2672.2008.04142.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=37320599&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hyun-Ju Moon
AU - Tae Seok Kang
AU - Tae Sung Kim
AU - Il Hyun Kang
AU - Ho Youn Ki
AU - Seung Hee Kim
AU - Soon Young Han
T1 - OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals.
JO - Journal of Applied Toxicology
JF - Journal of Applied Toxicology
Y1 - 2009/05//
VL - 29
IS - 4
M3 - Article
SP - 350
EP - 355
SN - 0260437X
AB - The article focuses on the study which emphasized a phase 3 trial to examine the reliability of the Hershberger assay using coded substances. The study which is part of the Organisation for Economic Co-operation and Development (OECD) Hershberger validation program in Korea involved male Sprague-Dwaley rats that were castrated at six weeks of age and allowed to recover for eight days. It is revealed that the OECD Hershberger assay to be reliable screening method for detecting androgen agonists and antagonists.
KW - Assaying
KW - Chemical inhibitors
KW - RESEARCH
KW - Rats
KW - Medical screening
KW - Androgens
KW - Toxicological interactions
KW - Toxicology
KW - Korea
KW - Linuror
KW - OECD Hershberger validation
KW - p′-DDE
KW - Trenbolone
KW - Organisation for Economic Co-operation & Development
N1 - Accession Number: 41032841; Hyun-Ju Moon 1; Tae Seok Kang 1; Tae Sung Kim 1; Il Hyun Kang 1; Ho Youn Ki 2; Seung Hee Kim 1; Soon Young Han 1; Email Address: soonyoungh@kfda.go.kr; Affiliations: 1: National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, Korea; 2: Laboratory Animal Team, CHA Stem Cell Institute, 606-16 Yeoksam 1-dong, Kangnam-gu, Seoul 135-081, Korea; Issue Info: May2009, Vol. 29 Issue 4, p350; Thesaurus Term: Assaying; Thesaurus Term: Chemical inhibitors; Thesaurus Term: RESEARCH; Subject Term: Rats; Subject Term: Medical screening; Subject Term: Androgens; Subject Term: Toxicological interactions; Subject Term: Toxicology; Subject: Korea; Author-Supplied Keyword: Linuror; Author-Supplied Keyword: OECD Hershberger validation; Author-Supplied Keyword: p′-DDE; Author-Supplied Keyword: Trenbolone ; Company/Entity: Organisation for Economic Co-operation & Development; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; NAICS/Industry Codes: 928120 International Affairs; NAICS/Industry Codes: 919110 International and other extra-territorial public administration; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1002/jat.1418
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hickson, DeMarc A.
AU - Wilhite, Rachel L.
AU - Petrini, Marcy F.
AU - White, Wendy B.
AU - Burchfiel, Cecil
T1 - Asthma and Asthma Severity among African American Adults in the Jackson Heart Study.
JO - Journal of Asthma
JF - Journal of Asthma
Y1 - 2009/05//
VL - 46
IS - 4
M3 - Article
SP - 421
EP - 428
SN - 02770903
AB - The aims of this study were to investigate the baseline prevalence of and risk factors associated with asthma, classify asthma severity, and describe medication use in a population-based sample of African American men and women 21 to 84 years of age from the Jackson Heart Study (JHS). Participants provided responses to respiratory and medical history questions and a medication inventory and underwent spirometry and other clinical examinations. These data were used to examine the extent to which novel and traditional risk factors were associated with asthma. Of the 4,098 participants included in this analysis, 9.4% reported lifetime asthma (5.7% current, 3.7% former), and current asthma was higher in women (6.8%) than in men (3.8%). An additional 9.8% reported an attack of wheeze with shortness of breath or non-doctor confirmed asthma (i.e., “probable” asthma). The mean forced expiratory volume in 1 second (FEV1)% predicted was lower in those reporting current asthma (women: 83.7 ± 18.0; men: 75.2 ± 16.8) compared to those not reporting asthma (women: 95.6 ± 16.7; men: 91.7 ± 16.0). Current and probable asthma was associated with lower serum cortisol levels and hypertension medication use, along with traditional risk factors (i.e., lower socio-economic status, higher global stress scores, obesity, and fair to poor perceived general health). Severe asthma was low among participants reporting current (9.8%), former (3.3%), and probable (4.9%) asthma. Asthma medication use was reported by nearly 60% of the participants reporting current asthma. Asthma in African American adults is associated with decreased serum cortisol, hypertension medication use, and considerable lung function impairment compared to those who did not report asthma. The prevalence of asthma in the JHS is lower than state and national estimates, although the estimates are not directly comparable. Furthermore, asthma is drastically underdiagnosed in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AFRICAN Americans -- Diseases
KW - ASTHMA
KW - RESEARCH
KW - WHEEZE
KW - DIAGNOSIS
KW - SEVERITY of illness index
KW - DISEASE prevalence
KW - RISK factors
KW - African Americans
KW - asthma
KW - asthma severity
KW - Jackson Heart Study
KW - wheezing
N1 - Accession Number: 40627863; Hickson, DeMarc A. 1,2 Wilhite, Rachel L. 2,3 Petrini, Marcy F. 4 White, Wendy B. 5 Burchfiel, Cecil 6; Affiliation: 1: Jackson State University, Jackson Heart Study, Coordinating Center 2: University of Mississippi Medical Center, Jackson Heart Study, Examination Center 3: Zuckermann College of Public Health, Department of Epidemiology, University of Arizona 4: Division of Pulmonary, Critical Care & Sleep Medicine, University of Mississippi Medical Center 5: Tougaloo College, Jackson Heart Study, Undergraduate Training Center 6: Centers for Disease Control and Prevention, Health Effects Laboratory Divison, National Institute for Occupational Safety and Health; Source Info: May2009, Vol. 46 Issue 4, p421; Subject Term: AFRICAN Americans -- Diseases; Subject Term: ASTHMA; Subject Term: RESEARCH; Subject Term: WHEEZE; Subject Term: DIAGNOSIS; Subject Term: SEVERITY of illness index; Subject Term: DISEASE prevalence; Subject Term: RISK factors; Author-Supplied Keyword: African Americans; Author-Supplied Keyword: asthma; Author-Supplied Keyword: asthma severity; Author-Supplied Keyword: Jackson Heart Study; Author-Supplied Keyword: wheezing; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/02770900902846307
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40627863&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Casanova, Manuel F.
AU - El-Baz, Ayman
AU - Mott, Meghan
AU - Mannheim, Glenn
AU - Hassan, Hossam
AU - Fahmi, Rachid
AU - Giedd, Jay
AU - Rumsey, Judith M.
AU - Switala, Andrew E.
AU - Farag, Aly
T1 - Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy.
JO - Journal of Autism & Developmental Disorders
JF - Journal of Autism & Developmental Disorders
Y1 - 2009/05//
VL - 39
IS - 5
M3 - Article
SP - 751
EP - 764
PB - Springer Science & Business Media B.V.
SN - 15733432
AB - Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Autism & Developmental Disorders is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTISM
KW - BRAIN imaging
KW - CORPUS callosum
KW - NERVOUS system -- Diseases
KW - NEURAL development
KW - DEVELOPMENTAL neurobiology
KW - DEVELOPMENTAL disabilities
KW - AFFERENT pathways
KW - MOTOR ability
KW - Autistic disorder
KW - Corpus callosum
KW - Magnetic resonance imaging
KW - Telencephalon
N1 - Accession Number: 38798805; Casanova, Manuel F. 1; Email Address: manuel.casanova@louisville.edu El-Baz, Ayman 2 Mott, Meghan 1 Mannheim, Glenn 3 Hassan, Hossam 4 Fahmi, Rachid 4 Giedd, Jay 5 Rumsey, Judith M. 6,7 Switala, Andrew E. 1 Farag, Aly 4; Affiliation: 1: Department of Psychiatry, University of Louisville, 500 South Preston St. Bldg. 55A Ste 210, Louisville, KY 40292, USA 2: Department of Bioengineering, University of Louisville, Louisville, KY, USA 3: Division of Psychiatry Products, Food and Drug Administration, Silver Spring, MD, USA 4: Department of Electrical and Computer Engineering, University of Louisville, Louisville, KY, USA 5: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA 6: Neurodevelopmental Disorders Branch, National Institute of Mental Health, Bethesda, MD, USA 7: Division of Adult Translational Research, National Institute of Mental Health, Bethesda, MD, USA; Source Info: May2009, Vol. 39 Issue 5, p751; Subject Term: AUTISM; Subject Term: BRAIN imaging; Subject Term: CORPUS callosum; Subject Term: NERVOUS system -- Diseases; Subject Term: NEURAL development; Subject Term: DEVELOPMENTAL neurobiology; Subject Term: DEVELOPMENTAL disabilities; Subject Term: AFFERENT pathways; Subject Term: MOTOR ability; Author-Supplied Keyword: Autistic disorder; Author-Supplied Keyword: Corpus callosum; Author-Supplied Keyword: Magnetic resonance imaging; Author-Supplied Keyword: Telencephalon; Number of Pages: 14p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s10803-008-0681-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38798805&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Casanova, Manuel F.
AU - El-Baz, Ayman
AU - Mott, Meghan
AU - Mannheim, Glenn
AU - Hassan, Hossam
AU - Fahmi, Rachid
AU - Giedd, Jay
AU - Rumsey, Judith M.
AU - Switala, Andrew E.
AU - Farag, Aly
T1 - Reduced Gyral Window and Corpus Callosum Size in Autism: Possible Macroscopic Correlates of a Minicolumnopathy.
JO - Journal of Autism & Developmental Disorders
JF - Journal of Autism & Developmental Disorders
Y1 - 2009/05//
VL - 39
IS - 5
M3 - Article
SP - 751
EP - 764
PB - Springer Science & Business Media B.V.
SN - 15733432
AB - Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Autism & Developmental Disorders is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUTISM
KW - BRAIN imaging
KW - CORPUS callosum
KW - NERVOUS system -- Diseases
KW - NEURAL development
KW - DEVELOPMENTAL neurobiology
KW - DEVELOPMENTAL disabilities
KW - AFFERENT pathways
KW - MOTOR ability
KW - Autistic disorder
KW - Corpus callosum
KW - Magnetic resonance imaging
KW - Telencephalon
N1 - Accession Number: 38798805; Casanova, Manuel F. 1; Email Address: manuel.casanova@louisville.edu; El-Baz, Ayman 2; Mott, Meghan 1; Mannheim, Glenn 3; Hassan, Hossam 4; Fahmi, Rachid 4; Giedd, Jay 5; Rumsey, Judith M. 6,7; Switala, Andrew E. 1; Farag, Aly 4; Source Information: May2009, Vol. 39 Issue 5, p751; Subject: AUTISM; Subject: BRAIN imaging; Subject: CORPUS callosum; Subject: NERVOUS system -- Diseases; Subject: NEURAL development; Subject: DEVELOPMENTAL neurobiology; Subject: DEVELOPMENTAL disabilities; Subject: AFFERENT pathways; Subject: MOTOR ability; Author-Supplied Keyword: Autistic disorder; Author-Supplied Keyword: Corpus callosum; Author-Supplied Keyword: Magnetic resonance imaging; Author-Supplied Keyword: Telencephalon; Number of Pages: 14p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s10803-008-0681-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=38798805&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Lute, Scott
AU - Brorson, Kurt
T1 - Bacteriophage and impurity carryover and total organic carbon release during extended protein A chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2009/05//
VL - 1216
IS - 18
M3 - Article
SP - 3774
EP - 3783
SN - 00219673
AB - Abstract: In the biopharmaceutical industry, column chromatography residuals are routinely assessed by the direct measurement of mock eluates. In this study, we evaluated virus and other impurity carryover between protein A cycles and the feasibility of using a total organic carbon (TOC) analyzer to monitor for column impurity leakage as a correlate for actual measured carryover in mock eluates. Commercial process intermediates were used in scaled down studies of two protein A media, ProSep A (Millipore, Bedford, MA, USA) and MabSelect SuRe (GE Healthcare, Uppsala, Sweden). The chromatography system was programmed to run up to 200 normal load/elution cycles with periodic blank cycles to measure protein and phage carryover, and water flush cycles to measure TOC release. Sustained phage carryover was evident in each study. Carryover and TOC release was lowest in the case where cleaning was most stringent (50mM NaOH/0.5M Na2SO4 with MabSelect SuRe). The TOC analysis at this time does not appear to be a viable practical means of measuring impurity carryover; direct measurements in mock eluates appears to be more predictive of column performance. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOPHARMACEUTICS
KW - PHARMACEUTICAL industry
KW - MONOCLONAL antibodies
KW - CHROMATOGRAPHIC analysis
KW - PROTEINS -- Analysis
KW - DRUG laws & regulations
KW - UPPSALA (Sweden)
KW - SWEDEN
KW - International regulatory guidance
KW - Monoclonal antibodies
KW - Protein A media
KW - Virus carryover
KW - Virus clearance
KW - GE Healthcare Inc.
N1 - Accession Number: 37348512; Lute, Scott 1 Brorson, Kurt; Email Address: kurt.brorson@fda.hhs.gov; Affiliation: 1: Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: May2009, Vol. 1216 Issue 18, p3774; Subject Term: BIOPHARMACEUTICS; Subject Term: PHARMACEUTICAL industry; Subject Term: MONOCLONAL antibodies; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: PROTEINS -- Analysis; Subject Term: DRUG laws & regulations; Subject Term: UPPSALA (Sweden); Subject Term: SWEDEN; Author-Supplied Keyword: International regulatory guidance; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: Protein A media; Author-Supplied Keyword: Virus carryover; Author-Supplied Keyword: Virus clearance; Company/Entity: GE Healthcare Inc.; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.chroma.2009.02.050
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Duan, John Z.
T1 - Two Commonly Used Methods for Exposure-Adverse Events Analysis: Comparisons and Evaluations.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2009/05//
VL - 49
IS - 5
M3 - Article
SP - 540
EP - 552
SN - 00912700
AB - The purpose of this study is to compare and evaluate logistic regression and time-to-event analysis, 2 commonly used methods for exposure-adverse event (AE) analyses. An AE data set selected from clinical trials is analyzed by both methods and the results are compared. The parameter estimates, odds ratios for logistic regression, and hazard ratios for time-to-event analysis for each AE are compared and further analyzed. In a data set involving 822 patients, 25 AEs are analyzed. A linear relationship is demonstrated between the parameter estimates from the 2 methods and between the odds ratios and hazard ratios. The small differences between the 2 analyses are related to the lower rate of the events and the weaker effects of the risk factors. Although the 2 methods can make predications for the risks, the severity, duration, and recurrence are not well defined. AE time profiles showing the onset, duration, and offset of AEs are important for risk assessment and management. Both analyses can provide information about exposure-AE relationship, and the results from the 2 analyses are consistent in most cases. One should not use the logistic model when length of follow-up varies because of biased estimates. The application of the 2 methods should be combined with AE profiling. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - CLINICAL trials
KW - CLINICAL medicine
KW - MEDICAL experimentation on humans
KW - HEALTH risk assessment
KW - DRUGS -- Side effects
KW - LOGISTIC regression analysis
KW - adverse events
KW - Exposure-response
KW - logistic regression
KW - proportional hazard model
KW - timeto-event analysis
N1 - Accession Number: 39773569; Duan, John Z. 1; Email Address: john.duan@fda.hhs.gov; Affiliation: 1: Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland; Source Info: May2009, Vol. 49 Issue 5, p540; Subject Term: MEDICAL research; Subject Term: CLINICAL trials; Subject Term: CLINICAL medicine; Subject Term: MEDICAL experimentation on humans; Subject Term: HEALTH risk assessment; Subject Term: DRUGS -- Side effects; Subject Term: LOGISTIC regression analysis; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: Exposure-response; Author-Supplied Keyword: logistic regression; Author-Supplied Keyword: proportional hazard model; Author-Supplied Keyword: timeto-event analysis; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 13p; Illustrations: 3 Charts, 6 Graphs; Document Type: Article
L3 - 10.1177/0091270009333485
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105536298
T1 - Anticariogenicity of casein phosphopeptide-amorphous calcium phosphate: a review of the literature.
AU - Llena C
AU - Forner L
AU - Baca P
Y1 - 2009/05//
N1 - Accession Number: 105536298. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Dental Care. NLM UID: 101090552.
KW - Cariostatic Agents -- Therapeutic Use
KW - Caseins -- Therapeutic Use
KW - Dental Caries -- Prevention and Control
KW - Biofilms
KW - Calcium -- Pharmacokinetics
KW - Dental Enamel -- Metabolism
KW - Dental Plaque
KW - Dentin -- Metabolism
KW - Phosphates -- Pharmacokinetics
KW - Saliva -- Physiology
KW - Tooth Erosion -- Prevention and Control
KW - Tooth Remineralization -- Methods
KW - Xerostomia -- Drug Therapy
SP - 1
EP - 9
JO - Journal of Contemporary Dental Practice
JF - Journal of Contemporary Dental Practice
JA - J CONTEMP DENT PRACT
VL - 10
IS - 3
PB - Jaypee Brothers Medical Publishers Private Limited
SN - 1526-3711
AD - Primary Care in Dental Public Health Service, Valencia University, Valencia, Spain. llena@uv.es
U2 - PMID: 19430620.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ohsawa, A.
T1 - Prevention criteria of electrostatic ignition by a charged cloud in grounded tanks
JO - Journal of Electrostatics
JF - Journal of Electrostatics
Y1 - 2009/05//
VL - 67
IS - 2/3
M3 - Article
SP - 280
EP - 284
SN - 03043886
AB - Abstract: In this paper, we present the criteria of space charge density and wall electric field required to prevent incendive discharges between a grounded protrusion and a charged cloud in cylindrical tanks grounded of up to ≈1.5×105 m3 in volume obtained by numerical investigations with wide ranges in the dimensions of the protrusions and tanks. To obtain such criteria, the thresholds of the charge densities of uniformly charged clouds for initiating a discharge at the tip of protrusions are numerically obtained. Furthermore, the transferred charges and energies of the discharges are estimated to investigate their incendivity. For evaluating the risk with a field measurement, the criterion of the electric fields at the side wall of the tanks for avoiding incendive discharges is also obtained. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electrostatics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FIRE prevention
KW - ELECTRIC discharges
KW - UNDERGROUND storage tanks
KW - SPACE charge
KW - ELECTRIC fields
KW - CHARGE transfer
KW - FIRE risk assessment
KW - Brush discharge
KW - Charged cloud
KW - Incendive discharge
KW - Risk assessment
KW - Streamer
N1 - Accession Number: 37816603; Ohsawa, A. 1; Email Address: ohsawa@s.jniosh.go.jp; Affiliation: 1: Electrical Safety Research Group, Institute of Industrial Safety, National Institute of Occupational Safety and Health, 1-4-6 Umezono, Kiyose, Tokyo 204-0024, Japan; Source Info: May2009, Vol. 67 Issue 2/3, p280; Subject Term: FIRE prevention; Subject Term: ELECTRIC discharges; Subject Term: UNDERGROUND storage tanks; Subject Term: SPACE charge; Subject Term: ELECTRIC fields; Subject Term: CHARGE transfer; Subject Term: FIRE risk assessment; Author-Supplied Keyword: Brush discharge; Author-Supplied Keyword: Charged cloud; Author-Supplied Keyword: Incendive discharge; Author-Supplied Keyword: Risk assessment; Author-Supplied Keyword: Streamer; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.elstat.2008.12.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Larry Lee
AU - Michael Flemmer
AU - Eun Gyung Lee
AU - Martin Harper
AU - Ming-I Lin
AU - William Groves
AU - Andris Freivalds
AU - James Slaven
T1 - A novel physiologic sampling pump capable of rapid response to breathingInformation related to the technology including licensing opportunities may be obtained by writing to Kathleen Goedel, Technology Development Coordinator, Office of Research and Technology Transfer, NIOSH, Centers for Disease Control and Prevention (CDC), 4676 Columbia Parkway, MS C-09, Cincinnati, OH 45226, USA. E-mail: kgoedel@cdc.gov, Fax: +1 (513) 533-8660, Tel: +1 (513) 533-8686.Disclaimer: the mention of any company names or products does not imply an endorsement by NIOSH or the Centers for Disease Control, and nor does it imply that alternative products are unavailable, or unable to be substituted after appropriate evaluation. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
JO - Journal of Environmental Monitoring
JF - Journal of Environmental Monitoring
Y1 - 2009/05//
VL - 11
IS - 5
M3 - Article
SP - 1020
EP - 1027
SN - 14640325
AB - The merits of using physiologic sampling pumps (PSPs) instead of using constant-flow sampling pumps, i.e., “traditional sampling pumps” (TSPs), are discussed. A novel PSP that overcomes shortcomings of previous PSP designs is presented. Calibrated valves are used to obviate pump inertia that has limited the system response and accuracy of prior work. Technologies that provide minute ventilation (VE) of subjects in real time may therefore be used to the limit of their own accuracies to sample inhalation exposures. Analysis of the design and data from a prototype are presented to show how air sampling can be modulated to follow breathing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Environmental Monitoring is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Physiology
KW - Air analysis
KW - Spectrum analysis
KW - Mass (Physics)
N1 - Accession Number: 39983407; Larry Lee 1; Michael Flemmer 1; Eun Gyung Lee 1; Martin Harper 1; Ming-I Lin 2; William Groves 2; Andris Freivalds 2; James Slaven 1; Affiliations: 1: National Institute for Occupational Safety and Health (NIOSH); 2: The Pennsylvania State University; Issue Info: May2009, Vol. 11 Issue 5, p1020; Thesaurus Term: Physiology; Thesaurus Term: Air analysis; Thesaurus Term: Spectrum analysis; Subject Term: Mass (Physics); Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - DAY, GREGORY A.
AU - VIRJI, M. ABBAS
AU - STEFANIAK, ALEKSANDR B.
T1 - Characterization of exposures among cemented tungsten carbide workers. Part II: Assessment of surface contamination and skin exposures to cobalt, chromium and nickel.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2009/05//May/Jun2009
VL - 19
IS - 4
M3 - Article
SP - 423
EP - 434
PB - Nature Publishing Group
SN - 15590631
AB - Cobalt, chromium and nickel are among the most commonly encountered contact allergens in the workplace, all used in the production of cemented tungsten carbides (CTC). Exposures to these metal-containing dusts are frequently associated with skin sensitization and/or development of occupational asthma. The objectives of this study were to assess the levels of cobalt, chromium and nickel on work surfaces and on workers’ skin in three CTC production facilities. At least one worker in each of 26 work areas (among all facilities) provided hand and neck wipe samples. Wipe samples were also collected from work surfaces frequently contacted by the 41 participating workers. Results indicated that all surfaces in all work areas were contaminated with cobalt and nickel, with geometric means (GMs) ranging from 4.1 to 3057 μg/100 cm2 and 1.1–185 μg/100 cm2, respectively; most surfaces were contaminated with chromium (GM=0.36–67 μg/100 cm2). The highest GM levels of all metals were found on control panels, containers and hand tools, whereas lowest levels were on office and telecommunication equipment. The highest GM levels of cobalt and nickel on skin were observed among workers in the powder-handling facility (hands: 388 and 24 μg; necks: 55 and 6 μg, respectively). Levels of chromium on workers’ skin were generally low among all facilities. Geometric standard deviations associated with surface and skin wipe measurements among work areas were highly variable. Exposure assessment indicated widespread contamination of multiple sensitizing metals in these three facilities, suggesting potential transfer of contaminants from surfaces to skin. Specific action, including improved housekeeping and training workers on appropriate use and care of personal protective equipment, should be implemented to reduce pathways of skin exposure. Epidemiologic studies of associated adverse health effects will likely require more biologically relevant exposure metrics to improve the ability to detect exposure–response relationships.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 423–434; doi:10.1038/jes.2008.33; published online 4 June 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHROMIUM
KW - NICKEL
KW - WORK environment
KW - BRONCHIAL diseases
KW - PUBLIC health
KW - OBSTRUCTIVE lung diseases
KW - LUNG diseases
KW - RESPIRATORY allergy
KW - dermal exposure
KW - exposure methods
KW - occupational asthma
KW - particle migration pathways
N1 - Accession Number: 37820877; DAY, GREGORY A. 1; Email Address: GDay@cdc.gov VIRJI, M. ABBAS 1 STEFANIAK, ALEKSANDR B. 1; Affiliation: 1: Division of Respiratory Disease Studies, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA; Source Info: May/Jun2009, Vol. 19 Issue 4, p423; Subject Term: CHROMIUM; Subject Term: NICKEL; Subject Term: WORK environment; Subject Term: BRONCHIAL diseases; Subject Term: PUBLIC health; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: LUNG diseases; Subject Term: RESPIRATORY allergy; Author-Supplied Keyword: dermal exposure; Author-Supplied Keyword: exposure methods; Author-Supplied Keyword: occupational asthma; Author-Supplied Keyword: particle migration pathways; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 416210 Metal service centres; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 12p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/jes.2008.33
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - CHORNG-MING CHENG
AU - VAN, KHANH T.
AU - WEN LIN
AU - RUBY, RICHARD M.
T1 - Interlaboratory Validation of a Real-Time PCR 24-Hour Rapid Method for Detection of Salmonella in Foods.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/05//
VL - 72
IS - 5
M3 - Article
SP - 945
EP - 951
SN - 0362028X
AB - The efficacy of a 24-h Salmonella real-time, or quantitative, PCR (qPCR) detection method was assessed through a collaborative effort involving eight Federal and state laboratories. Eleven foods including mashed potatoes, soft cheese, chili powder, chocolate, eggs, sprouts, apple juice, fish, shrimp, ground beef, and ground chicken were tested. For each food, seven blind samples were distributed to each participant for testing. These included six samples equivalently inoculated with 1 to 5 CFU/25 g of various serotypes of Salmonella (Gaminara, Weltevreden, Heidelberg, Senftenberg, Enteritidis, Newport, Typhimurium, and Kentucky for each food) and 10 to 50 CFU/25 g of the competitor Enterobacter cloacae. The seventh sample was inoculated with 10 to 50 CFU/25 g of the competitor, E. cloacae, only. These samples were tested for Salmonella by using four methods in parallel: (i) 24-h qPCR method detecting Salmonella from modified buffered peptone water enrichment medium; (ii) 48-h qPCR method detecting Salmonella from a secondary selective enrichment broth; (iii) modified Bacteriological Analytical Manual method; and (iv) VIDAS, an immunoassay system. The results of the statistical analysis showed there was no significant (P ≥ 0.05) difference between either of the qPCR methods and the modified Bacteriological Analytical Manual method for 10 of 11 foods. For the one exception, sprouts, detection by qPCR required 48 h. Both qPCR methods showed a detection limit of 0.08 to 0.2 CFU/g. These results provide a solid basis for using this 24-h qPCR rapid screening method to detect Salmonella in foods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - Salmonella -- Detection
KW - Polymerase chain reaction
KW - Peptones
KW - Immunoassay
N1 - Accession Number: 40118692; CHORNG-MING CHENG 1; Email Address: chorng-ming.cheng@fda.hhs.gov; VAN, KHANH T. 1; WEN LIN 2; RUBY, RICHARD M. 1; Affiliations: 1: U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Southwest, 19701 Fairchild, lrvine, California 92612; 2: U.S. Food and Drug Administration, Office of Regulatory Affairs, Division of Field Science, 5600 Fishers Lane, Room 12-41, Rockville, Maryland 20857, USA; Issue Info: May2009, Vol. 72 Issue 5, p945; Thesaurus Term: Food pathogens; Subject Term: Salmonella -- Detection; Subject Term: Polymerase chain reaction; Subject Term: Peptones; Subject Term: Immunoassay; Number of Pages: 7p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - HAMOVIC, MICHAEL
AU - BARTZ, JERRY A.
AU - SCHNEIDER, KEITH R.
AU - TENNEY, JOEL D.
T1 - Chlorine Dioxide Gas from an Aqueous Solution: Reduction of Salmonella in Wounds on Tomato Fruit and Movement to Sinks in a Treatment Chamber.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/05//
VL - 72
IS - 5
M3 - Article
SP - 952
EP - 958
SN - 0362028X
AB - Chlorine dioxide (CIO2) off-gassed from an aqueous solution and reacted incrementally with potassium iodide solutions (sinks). After 30 min, 45% of the initial dose was detected as chlorite ion in the sink, whereas 35% of the initial dose was still in the source. Aqueous solutions of CIO2 can be used as a source of CIO2 gas in various laboratory experiments involving treatment of fruits or vegetables. Movement from source to sink is continuous, which precludes the development of large headspace concentrations and the need for a tight chamber seal. When the source solution has dissipated, the chamber can be opened safely as there is little free CIO2 remaining in the headspace. In tests with whole, wound-inoculated tomato fruit, at both green and pink stages of ripeness, the control of Salmonella enterica serotype Typhimurium in wounds varied with the weight of gas used. The number of viable cells of Typhimurium recovered was reduced by >5 log units when ≤0.5 mg of CIO2 was applied to three pieces of fruit during a 2-h treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlorine dioxide
KW - Solution (Chemistry)
KW - Salmonella
KW - Outgassing (Low pressure environments)
KW - Tomatoes -- Diseases & pests
N1 - Accession Number: 40118693; HAMOVIC, MICHAEL 1; BARTZ, JERRY A. 2; Email Address: softbart@ufl.edu; SCHNEIDER, KEITH R. 3; TENNEY, JOEL D. 4; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland; 2: Department of Plant Pathology, University of Florida, Gainesville, Florida; 3: Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida; 4: ICA TriNova Corporation, LLC, Newnan, Georgia, USA; Issue Info: May2009, Vol. 72 Issue 5, p952; Thesaurus Term: Chlorine dioxide; Thesaurus Term: Solution (Chemistry); Thesaurus Term: Salmonella; Subject Term: Outgassing (Low pressure environments); Subject Term: Tomatoes -- Diseases & pests; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 7p; Illustrations: 3 Black and White Photographs, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - ROZAND, CHRISTINE
AU - FENG, PETER C. H.
T1 - Specificity Analysis of a Novel Phage-Derived Ligand in an Enzyme-Linked Fluorescent Assay for the Detection of Escherichia coli O157:H7.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/05//
VL - 72
IS - 5
M3 - Article
SP - 1078
EP - 1081
SN - 0362028X
AB - An assay using a phage-derived ligand to capture Escherichia coli O157:H7 prior to antibody detection was evaluated for assay specificity. Analysis of 200 strains showed that the assay was highly specific for the O157 serogroup. It detected all the O157:H7 strains including Shiga toxin-producing O157 nonmotile strains as well as O157 non-H7 strains. In addition, the assay detected various O157:H7 phenotypic variants that are not easily detected by routine analytical methods, as well as a rough strain that did not express O157 antigen and therefore is undetectable serologically. The phage ligand assay showed no cross-reactivity to the other E. coli serotypes. Isolates of Salmonella group N and a few Citrobacterfreundii strains that cross-reacted with anti-O157 sera also showed cross-reactivity with the phage ligand. However, other strains that cross-reacted serologically with anti-O157 sera were correctly identified as negative with the phage ligand assay, including several strains of E. coli that nonspecifically autoagglutinate latex reagents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteriophages
KW - Antigens
KW - Escherichia coli
KW - Ligands (Biochemistry)
KW - Enzyme-linked immunosorbent assay
KW - Escherichia coli O157:H7
N1 - Accession Number: 40118710; ROZAND, CHRISTINE 1; FENG, PETER C. H. 2; Email Address: peter.feng@fda.hhs.gov; Affiliations: 1: Unité de Microbiologie Alimentaire et Prévisionnelle, Ecole Vétérinaire de Lyon, Lyon, France; 2: Division of Microbiology, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; Issue Info: May2009, Vol. 72 Issue 5, p1078; Thesaurus Term: Bacteriophages; Thesaurus Term: Antigens; Thesaurus Term: Escherichia coli; Subject Term: Ligands (Biochemistry); Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Escherichia coli O157:H7; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105536820
T1 - Early collaboration for adaptation: addressing depression in low-income new mothers.
AU - Pfefferle SG
AU - Cooper B
AU - Layton D
AU - Rohrbach S
Y1 - 2009/05//
N1 - Accession Number: 105536820. Language: English. Entry Date: 20090626. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; Public Health; USA. Special Interest: Obstetric Care; Psychiatry/Psychology; Public Health; Women's Health. NLM UID: 9103800.
KW - Collaboration
KW - Depression -- Therapy
KW - Maternal-Child Nursing
KW - Mothers -- Psychosocial Factors
KW - Pilot Studies
KW - Research Personnel
KW - Community Health Nursing
KW - Community Health Services
KW - Decision Making
KW - Female
KW - Health Services Accessibility
KW - Home Visits
KW - Institutional Review
KW - Medically Underserved
KW - Mental Health Services
KW - Missouri
KW - Problem Solving
KW - Socioeconomic Factors
SP - 539
EP - 544
JO - Journal of Health Care for the Poor & Underserved
JF - Journal of Health Care for the Poor & Underserved
JA - J HEALTH CARE POOR UNDERSERV
VL - 20
IS - 2
CY - Baltimore, Maryland
PB - Johns Hopkins University Press
AB - This paper describes the development and implementation of a collaborative research project between a community agency and university-based researcher. The goal of the project was to address depression in low-income new mothers who would not ordinarily have access to mental health services.
SN - 1049-2089
AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, 1 Brookings Dr., Box 1093, St. Louis, MO 63130, USA. spfefferle@gwbmail.wustl.edu
U2 - PMID: 19395847.
DO - 10.1353/hpu.0.0134
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sharp, Dan S.
AU - Tauger, Mark B.
T1 - Natan 'Nikolai' Abramovich Vigdorchik (1874-1954): social activism and public health in early 20th-century Russia.
JO - Journal of Medical Biography
JF - Journal of Medical Biography
Y1 - 2009/05//
VL - 17
IS - 2
M3 - Article
SP - 75
EP - 80
SN - 09677720
AB - The article presents a profile of the life and medical career of Doctor Natan ‘Nikolai' Abramovich Vigdorchik, a physician known for his role in introducing social security and promoting public health in early 20th century Russia. Vigdorchik's rise from Jewish working-class origins to a career in political activism for labor rights, occupational safety, and public health is described. The doctor's 1935 publication concerning the association between lead and hypertension is said to illustrate Vigdorchik's contribution to modern epidemiological methods by describing statistical bias in the study of hospital patients.
KW - SOCIAL security
KW - ACTIVISTS
KW - JEWISH physicians
KW - PUBLIC health
KW - SOVIET Union -- Social conditions -- 1917-1945
KW - SOVIET Union
KW - VIGDORCHIK, Natan Abramovich
N1 - Accession Number: 41334300; Sharp, Dan S. 1; Email Address: DSharp@cdc.gov; Tauger, Mark B. 2; Affiliations: 1 : Associate Director for Science, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.; 2 : Associate Professor, Department of History of West Virginia University.; Source Info: May2009, Vol. 17 Issue 2, p75; Historical Period: 1874 to 1954; Subject Term: SOCIAL security; Subject Term: ACTIVISTS; Subject Term: JEWISH physicians; Subject Term: PUBLIC health; Subject Term: SOVIET Union -- Social conditions -- 1917-1945; Subject: SOVIET Union; Number of Pages: 6p; Illustrations: 1 Black and White Photograph; Document Type: Article
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DP - EBSCOhost
DB - hia
ER -
TY - JOUR
AU - Ghosh, Kaushik
AU - Tiwari, Ram C.
T1 - A unified approach to variations of ranked set sampling with applications.
JO - Journal of Nonparametric Statistics
JF - Journal of Nonparametric Statistics
Y1 - 2009/05//
VL - 21
IS - 4
M3 - Article
SP - 471
EP - 485
SN - 10485252
AB - In this article, we develop a general theory of inference using data collected from different variations of ranked set sampling. Such variations include balanced and unbalanced ranked set sampling, balanced and unbalanced k-tuple ranked set sampling, nomination sampling, simple random sampling, as well as a combination of them. We provide methods of estimating the underlying distribution function as well as its functionals and establish the asymptotic properties of the resulting estimators. The results so obtained can be used to develop nonparametric procedures for one- and two-sample problems. Some investigation of the small-sample properties of these estimators is also provided. We conclude with an application to a real-life example. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Nonparametric Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFERENCE (Logic)
KW - REASONING (Logic)
KW - SAMPLING (Statistics)
KW - DISTRIBUTION (Probability theory)
KW - PROBABILITY theory
KW - STATISTICS
KW - control percentile test
KW - empirical process
KW - extreme ranked set sample
KW - P-P plot
KW - Q-Q plot
KW - Wilcoxon-Mann-Whitney test
N1 - Accession Number: 37709459; Ghosh, Kaushik 1; Email Address: kaushik.ghosh@unlv.edu Tiwari, Ram C. 2; Affiliation: 1: Department of Mathematical Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA 2: Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; Source Info: May2009, Vol. 21 Issue 4, p471; Subject Term: INFERENCE (Logic); Subject Term: REASONING (Logic); Subject Term: SAMPLING (Statistics); Subject Term: DISTRIBUTION (Probability theory); Subject Term: PROBABILITY theory; Subject Term: STATISTICS; Author-Supplied Keyword: control percentile test; Author-Supplied Keyword: empirical process; Author-Supplied Keyword: extreme ranked set sample; Author-Supplied Keyword: P-P plot; Author-Supplied Keyword: Q-Q plot; Author-Supplied Keyword: Wilcoxon-Mann-Whitney test; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 15p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/10485250802652077
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Qun
AU - Sun, Albert Y.
AU - Simonyi, Agnes
AU - Miller, Dennis K.
AU - Smith, Robert E.
AU - Luchtefeld, Ronald G.
AU - Korthuis, Ronald J.
AU - Sun, Grace Y.
T1 - Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administration
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
Y1 - 2009/05//
VL - 20
IS - 5
M3 - Article
SP - 369
EP - 377
SN - 09552863
AB - Abstract: Oxidative stress has been regarded as an important underlying cause for the delayed neuronal death (DND) after cerebral ischemia. In this study, the effects of short-term oral administration of grape polyphenol extract (GPE) on ischemia/reperfusion (I/R) injury in a gerbil global ischemia model were determined. Ischemia was induced by occlusion of the common carotid arteries for 5 min. GPE (30 mg/ml)-containing formula or formula without GPE was administered daily via gavage for 4 days prior to and/or for 4 days after I/R. I/R resulted in hyperlocomotion, extensive DND, oxidative and fragmented DNA damage, and an increase in reactive astrocytes and microglial cells in the hippocampal CA1 region. GPE administration for 4 days prior to I/R and for 4 days after I/R attenuated DND, DNA damage and glial cell activation. However, neuroprotection was more pronounced when GPE was administered for 4 days after I/R than when administered for 4 days prior to I/R. GPE administration after I/R attenuated I/R-induced hyperlocomotion. These findings indicate that oral GPE intake may confer protection against I/R injury and emphasize that early intervention may be an effective therapeutic measure for ameliorating brain injury in stroke. [Copyright &y& Elsevier]
AB - Copyright of Journal of Nutritional Biochemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WOUNDS & injuries
KW - Comparative studies
KW - Grapes -- Therapeutic use
KW - Plant polyphenols -- Therapeutic use
KW - Plant extracts -- Therapeutic use
KW - Reperfusion injury -- Treatment
KW - Gerbils as laboratory animals
KW - Ischemia -- Treatment
KW - Nervous system
KW - TREATMENT
KW - 4′,6-diamidine-2′-phenylindole ( DAPI )
KW - 8-hydroxyl-deoxyguanosine ( 8-OHdG )
KW - common carotid arteries ( CCA )
KW - delayed neuronal death ( DND )
KW - Glial cell activation
KW - glial fibrillary acidic protein ( GFAP )
KW - grape polyphenol extract ( GPE )
KW - Grape polyphenols
KW - Ischemia/reperfusion
KW - ischemia/reperfusion ( I/R )
KW - liquid chromatography-mass spectrometry ( LC-MS )
KW - Locomotor activity
KW - Neuronal death
KW - Oxidative stress
KW - reactive oxygen species ( ROS )
KW - regional cerebral blood flow ( rCBF )
KW - terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling ( TUNEL )
N1 - Accession Number: 37347648; Wang, Qun 1; Sun, Albert Y. 2; Simonyi, Agnes 1; Miller, Dennis K. 3; Smith, Robert E. 4; Luchtefeld, Ronald G. 4; Korthuis, Ronald J. 2; Sun, Grace Y. 1; Email Address: sung@missouri.edu; Affiliations: 1: Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA; 2: Department of Medical Pharmacology and Physiology and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA; 3: Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA; 4: The US Food and Drug Administration, Lenexa, KS 66214, USA; Issue Info: May2009, Vol. 20 Issue 5, p369; Thesaurus Term: WOUNDS & injuries; Thesaurus Term: Comparative studies; Subject Term: Grapes -- Therapeutic use; Subject Term: Plant polyphenols -- Therapeutic use; Subject Term: Plant extracts -- Therapeutic use; Subject Term: Reperfusion injury -- Treatment; Subject Term: Gerbils as laboratory animals; Subject Term: Ischemia -- Treatment; Subject Term: Nervous system; Subject Term: TREATMENT; Author-Supplied Keyword: 4′,6-diamidine-2′-phenylindole ( DAPI ); Author-Supplied Keyword: 8-hydroxyl-deoxyguanosine ( 8-OHdG ); Author-Supplied Keyword: common carotid arteries ( CCA ); Author-Supplied Keyword: delayed neuronal death ( DND ); Author-Supplied Keyword: Glial cell activation; Author-Supplied Keyword: glial fibrillary acidic protein ( GFAP ); Author-Supplied Keyword: grape polyphenol extract ( GPE ); Author-Supplied Keyword: Grape polyphenols; Author-Supplied Keyword: Ischemia/reperfusion; Author-Supplied Keyword: ischemia/reperfusion ( I/R ); Author-Supplied Keyword: liquid chromatography-mass spectrometry ( LC-MS ); Author-Supplied Keyword: Locomotor activity; Author-Supplied Keyword: Neuronal death; Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: regional cerebral blood flow ( rCBF ); Author-Supplied Keyword: terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling ( TUNEL ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jnutbio.2008.04.007
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Junghoon Jang
AU - Younshik Chung
AU - Chansoo Kim
AU - Seongho Song
T1 - Bayesian meta-analysis using skewed elliptical distributions.
JO - Journal of Statistical Computation & Simulation
JF - Journal of Statistical Computation & Simulation
Y1 - 2009/05//
VL - 79
IS - 5
M3 - Article
SP - 691
EP - 704
SN - 00949655
AB - Meta-analysis refers to a quantitative method for combining results from independent studies in order to draw overall conclusions. We consider hierarchical models including selection models under a skewed heavy tailed error distribution proposed originally by Chen, Dey, and Shao [M. H. Chen, D. K. Dey, Q. M. Shao, A new skewed link model for dichotomous quantal response data, J. Amer. Statist. Assoc. 94 (1983), pp. 1172-1186.] and Branco and Dey [D. Branco and D.K. Dey, A general class of multivariate skew-elliptical distributions, J. Multivariate Anal. 79, pp. 99-113.]. These rich classes of models combine the information of independent studies, allowing investigation of variability both between and within studies and incorporating weight functions. We constructed a detailed computational scheme under skewed normal and skewed Student's t distribution using the MCMC method. Bayesian model selection was conducted by Bayes factor under a different skewed error. Finally, we illustrated our methodology using a real data example taken from Johnson [M.F. Johnson, Comparative efficacy of Naf and SMFP dentifrices in caries prevention: a meta-analysis overview, J Eur. Organ. Caries Res. 27 (1993), pp. 328-336.]. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Statistical Computation & Simulation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - META-analysis
KW - BAYESIAN analysis
KW - QUANTITATIVE research
KW - MULTILEVEL models (Statistics)
KW - HARMONIC functions (Mathematics)
KW - Bayes factor
KW - Bayesian model selection
KW - density generator
KW - hierarchical selection model
KW - Laplace-metropolis estimator
KW - meta-analysis
KW - skewed elliptical distribution
KW - weight function
N1 - Accession Number: 38028689; Junghoon Jang 1 Younshik Chung 2; Email Address: yschung@pusan.ac.kr Chansoo Kim 3 Seongho Song 4; Affiliation: 1: Biostatistics Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea 2: Department of Statistics, Pusan National University, Pusan, South Korea 3: Department of Applied Mathematics, Kongju National University, Gongju, South Korea 4: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, US; Source Info: May2009, Vol. 79 Issue 5, p691; Subject Term: META-analysis; Subject Term: BAYESIAN analysis; Subject Term: QUANTITATIVE research; Subject Term: MULTILEVEL models (Statistics); Subject Term: HARMONIC functions (Mathematics); Author-Supplied Keyword: Bayes factor; Author-Supplied Keyword: Bayesian model selection; Author-Supplied Keyword: density generator; Author-Supplied Keyword: hierarchical selection model; Author-Supplied Keyword: Laplace-metropolis estimator; Author-Supplied Keyword: meta-analysis; Author-Supplied Keyword: skewed elliptical distribution; Author-Supplied Keyword: weight function; Number of Pages: 14p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/00949650801891595
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38028689&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murphy, William J.
AU - Byrne, David C.
AU - Gauger, Dan
AU - Ahroon, William A.
AU - Berger, Elliott
AU - Gerges, Samir N. Y.
AU - McKinley, Richard
AU - Witt, Brad
AU - Krieg, Edward F.
T1 - Results of the National Institute for Occupational Safety and Health—U.S. Environmental Protection Agency Interlaboratory Comparison of American National Standards Institute S12.6-1997 Methods A and B.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2009/05//
VL - 125
IS - 5
M3 - Article
SP - 3262
EP - 3277
SN - 00014966
AB - The National Institute for Occupational Safety and Health and the Environmental Protection Agency sponsored the completion of an interlaboratory study to compare two fitting protocols specified by ANSI S12.6-1997 (R2002) [(2002). American National Standard Methods for the Measuring Real-Ear Attenuation of Hearing Protectors, American National Standards Institute, New York]. Six hearing protection devices (two earmuffs, foam, premolded, custom-molded earplugs, and canal-caps) were tested in six laboratories using the experimenter-supervised, Method A, and (naïve) subject-fit, Method B, protocols with 24 subjects per laboratory. Within-subject, between-subject, and between-laboratory standard deviations were determined for individual frequencies and A-weighted attenuations. The differences for the within-subject standard deviations were not statistically significant between Methods A and B. Using between-subject standard deviations from Method A, 3–12 subjects would be required to identify 6-dB differences between attenuation distributions. Whereas using between-subject standard deviations from Method B, 5–19 subjects would be required to identify 6-dB differences in attenuation distributions of a product tested within the same laboratory. However, the between-laboratory standard deviations for Method B were -0.1 to 3.0 dB less than the Method A results. These differences resulted in considerably more subjects being required to identify statistically significant differences between laboratories for Method A (12–132 subjects) than for Method B (9–28 subjects). [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STANDARD deviations
KW - EAR
KW - EQUIPMENT & supplies
KW - HEARING aids
KW - ATTENUATION (Physics)
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
KW - UNITED States. Environmental Protection Agency
KW - AMERICAN National Standards Institute
N1 - Accession Number: 39054856; Murphy, William J. 1; Email Address: wmurphy@cdc.gov Byrne, David C. 1 Gauger, Dan 2 Ahroon, William A. 3 Berger, Elliott 4 Gerges, Samir N. Y. 5 McKinley, Richard 6 Witt, Brad 7 Krieg, Edward F. 8; Affiliation: 1: Hearing Loss Prevention Team, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-27, Cincinnati, Ohio 45226-1998 2: Bose Corporation, MS271E, 145 Pennsylvania Avenue, Framingham, Massachusetts 01701-9168 3: U.S. Army Aeromedical Research Laboratory, 6901 Andrews Avenue, P.O. Box 620577, Fort Rucker, Alabama 36362-0577 4: Aearo Technologies, 7911 Zionsville Road, Indianapolis, Indiana 46268-1657 5: Departamento de Engenharia Mecânica, Laboratório de Vibrações e Acústica, (LARI and LAEPI), Universidade Federal de Santa Catarina, Cx. P. 476, CEP 88040-900, Florianópolis, SC, Brazil 6: Human Effectiveness Directorate, AFRL/HECB, 2610 7th Street, Building 441, Dayton, Ohio 45433 7: Howard Leight Industries, 7828 Waterville Road, San Diego, California 92154 8: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, Ohio 45226; Source Info: May2009, Vol. 125 Issue 5, p3262; Subject Term: STANDARD deviations; Subject Term: EAR; Subject Term: EQUIPMENT & supplies; Subject Term: HEARING aids; Subject Term: ATTENUATION (Physics); Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health DUNS Number: Company/Entity: UNITED States. Environmental Protection Agency DUNS Number: Company/Entity: AMERICAN National Standards Institute DUNS Number: 073294837; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 16p; Illustrations: 12 Charts, 3 Graphs; Document Type: Article
L3 - 10.1121/1.3095803
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Huy, Janice
AU - Pauli, Carma J.
T1 - Opportunities with US Public Health Service
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2009/05//
VL - 109
IS - 5
M3 - Letter
SP - 809
EP - 809
SN - 00028223
N1 - Accession Number: 38331076; Huy, Janice 1 Pauli, Carma J. 2; Affiliation: 1: Chief Dietitian Officer, US Public Health Service, Cincinnati, OH 2: Lead Associate Recruiter, US Public Health Service, Covington, GA; Source Info: May2009, Vol. 109 Issue 5, p809; Number of Pages: 1p; Document Type: Letter
L3 - 10.1016/j.jada.2009.03.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105531881
T1 - U.S. Public Health Service Commissioned Corps pharmacists: making a difference in advancing the nation's health.
AU - Flowers L
AU - Wick J
AU - Figg WD Sr
AU - McClelland RH
AU - Shiber M
AU - Britton JE
AU - Ngo DK
AU - Borders-Hemphill V
AU - Mead C
AU - Zee J
AU - Huntzinger P
AU - Flowers, Louis
AU - Wick, Jeannette
AU - Figg, William Douglas Sr
AU - McClelland, Robert H
AU - Shiber, Michael
AU - Britton, James E
AU - Ngo, Diem-Kieu H
AU - Borders-Hemphill, Vicky
AU - Mead, Christina
Y1 - 2009/05//May/Jun2009
N1 - Accession Number: 105531881. Language: English. Entry Date: 20090724. Revision Date: 20161119. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: Z99 CA999999//Intramural NIH HHS/United States. NLM UID: 101176252.
KW - Pharmacists -- Administration
KW - Pharmacy Service -- Administration
KW - United States Public Health Service -- Administration
KW - Career Planning and Development
KW - Health Care Delivery -- Administration
KW - Professional Role
KW - United States
KW - Human
SP - 446
EP - 452
JO - Journal of the American Pharmacists Association: JAPhA
JF - Journal of the American Pharmacists Association: JAPhA
JA - J AM PHARM ASSOC
VL - 49
IS - 3
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
AB - Objective: To describe how U.S. Public Health Service (PHS) pharmacists serving in jobs that are normal for them, but considerably different than those found in the private sector, are making a difference in advancing the nation's health.Summary: Pharmacists who serve in the Commissioned Corps of PHS fill roles that are considerably different than their counterparts in the private sector. Their work takes them out from behind the counter and into the world. Pharmacy officers advance the health and safety of the nation by their involvement in the delivery of direct patient care to medically underserved people, national security, drug vigilance, research, and policy-making endeavors. PHS pharmacists fill essential public health leadership and service roles throughout the U.S. Department of Health and Human Services (HHS) and certain non-HHS federal agencies and programs. The Health Resources and Services Administration, National Institutes of Health, Federal Bureau of Prisons, Indian Health Service, Food and Drug Administration, and U.S. Coast Guard are among the many federal agencies in which pharmacy officers are assigned.Conclusion: In each setting, PHS pharmacists find traditional roles augmented with assignments and challenges that broaden the scope of their practice.
SN - 1544-3191
AD - Division of Training and Development, Office of Training and Communications, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
U2 - PMID: 19443327.
DO - 10.1331/JAPhA.2009.08036
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kuroda, Hitoshi
AU - Kutner, Robert H.
AU - Bazan, Nicolas G.
AU - Reiser, Jakob
T1 - Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2009/05//
VL - 157
IS - 2
M3 - Article
SP - 113
EP - 121
SN - 01660934
AB - Abstract: During the past 12 years, lentiviral vectors have emerged as valuable tools for transgene delivery because of their ability to transduce nondividing cells and their capacity to sustain long-term transgene expression. Despite significant progress, the production of high-titer high-quality lentiviral vectors is cumbersome and costly. The most commonly used method to produce lentiviral vectors involves transient transfection using calcium phosphate (CaP)-mediated precipitation of plasmid DNAs. However, inconsistencies in pH can cause significant batch-to-batch variations in lentiviral vector titers, making this method unreliable. This study describes optimized protocols for lentiviral vector production based on polyethylenimine (PEI)-mediated transfection, resulting in more consistent lentiviral vector stocks. To achieve this goal, simple production methods for high-titer lentiviral vector production involving transfection of HEK 293T cells immediately after plating were developed. Importantly, high titers were obtained with cell culture media lacking serum or other protein additives altogether. As a consequence, large-scale lentiviral vector stocks can now be generated with fewer batch-to-batch variations and at reduced costs and with less labor compared to the standard protocols. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LENTIVIRUSES
KW - GENETIC vectors
KW - IMINES
KW - GENE transfection
KW - TRANSGENES -- Expression
KW - CALCIUM phosphate
KW - DNA
KW - COST effectiveness
KW - Lentiviral vectors
KW - Polyethylenimine transfection
KW - Protein-free media
KW - Vector production
N1 - Accession Number: 37346283; Kuroda, Hitoshi 1,2 Kutner, Robert H. 1 Bazan, Nicolas G. 2 Reiser, Jakob 1,3; Email Address: Jakob.Reiser@fda.hhs.gov; Affiliation: 1: Gene Therapy Program, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA 2: Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA 3: Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, FDA/Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA; Source Info: May2009, Vol. 157 Issue 2, p113; Subject Term: LENTIVIRUSES; Subject Term: GENETIC vectors; Subject Term: IMINES; Subject Term: GENE transfection; Subject Term: TRANSGENES -- Expression; Subject Term: CALCIUM phosphate; Subject Term: DNA; Subject Term: COST effectiveness; Author-Supplied Keyword: Lentiviral vectors; Author-Supplied Keyword: Polyethylenimine transfection; Author-Supplied Keyword: Protein-free media; Author-Supplied Keyword: Vector production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jviromet.2008.11.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ma, Yun Kun
AU - Khan, Arifa S.
T1 - Evaluation of different RT enzyme standards for quantitation of retroviruses using the single-tube fluorescent product-enhanced reverse transcriptase assay
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2009/05//
VL - 157
IS - 2
M3 - Article
SP - 133
EP - 140
SN - 01660934
AB - Abstract: PCR-based reverse transcriptase (RT) assays are highly sensitive for broad detection of retroviruses. These assays are currently used for demonstrating the absence of retroviral contamination in vaccines and can also be applied to clinical and laboratory research to investigate low-virus replication. A single-tube fluorescent product-enhanced reverse transcriptase assay (STF-PERT) has been published that was highly sensitive for retrovirus detection (<10 virions), with enhanced reproducibility and increased efficiency [Sears, J.F., Khan, A.S., 2003. Single-tube fluorescent product-enhanced reverse transcriptase assay with AmpliWax (STF-PERT) for retrovirus quantitation. J. Virol. Meth. 108, 139–142]. In this report, the step-by-step setup and performance of the STF-PERT assay is described and sensitivity, reproducibility and specificity of the assay reported using three different RTs as standards: avian myeloblastosis virus (AMV) RT, murine leukemia virus (MMLV) RT, and human immunodeficiency virus type 1 (HIV-1) RT. Evaluation of virus stocks showed about 1–2 logs difference in RT detection and retrovirus quantitation with the different RT enzyme standards; in general, virus determination using HIV-1 RT was comparable to using the relevant virus RT. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REVERSE transcriptase
KW - REVERSE transcriptase polymerase chain reaction
KW - RETROVIRUSES
KW - FLUORESCENCE
KW - VIRUSES -- Identification
KW - BIOLOGICAL assay
KW - VIRAL replication
KW - Retroviruses
KW - Reverse transcriptase
KW - STF-PERT assay
N1 - Accession Number: 37346285; Ma, Yun Kun 1 Khan, Arifa S.; Email Address: arifa.khan@fda.hhs.gov; Affiliation: 1: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics, Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, United States; Source Info: May2009, Vol. 157 Issue 2, p133; Subject Term: REVERSE transcriptase; Subject Term: REVERSE transcriptase polymerase chain reaction; Subject Term: RETROVIRUSES; Subject Term: FLUORESCENCE; Subject Term: VIRUSES -- Identification; Subject Term: BIOLOGICAL assay; Subject Term: VIRAL replication; Author-Supplied Keyword: Retroviruses; Author-Supplied Keyword: Reverse transcriptase; Author-Supplied Keyword: STF-PERT assay; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jviromet.2009.01.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Adamo, Joan E.
AU - Liu, Teresa
AU - Schmeisser, Falko
AU - Zhiping Ye
T1 - Optimizing Viral Protein Yield of Influenza Virus Strain A/Vietnam/1203/2004 by Modification of the Neuraminidase Gene.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/05//
VL - 83
IS - 9
M3 - Article
SP - 4203
EP - 4209
SN - 0022538X
AB - The preparation of high-yield prepandemic influenza virus H5N1 strains has presented a challenge to both researchers and vaccine manufacturers. The reasons for the relatively low yield of the H5N1 strains are not fully understood, but it might be partially dependent on the interactions between the hemagglutinin (HA) or neuraminidase (NA) surface glycoprotein and other influenza virus proteins. In this study, we have constructed chimeras between the A/Puerto Rico/8/34 (PR8) NA gene and the A/Vietnam/1203/2004 (VN1203) NA gene that have resulted in an increase in the virus yield of the reassortant viruses without a significant loss of NA activity. By combining the amino terminus of NA from the PR8 strain with the carboxy terminus of NA from VN1203, the surface epitopes unique to the H5N1 VN1203 NA glycoprotein are maintained. This reassortant virus had a higher titer and total protein yield in eggs, grew to a higher titer, produced large plaques on MDCK cells, and retained NA activity. This work describes a novel recombinant technique designed to increase the yields of vaccine candidates for the production of pandemic influenza virus vaccines. The relationship between the infectivity and protein yield of the reassortants also is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRAL proteins
KW - NEURAMINIDASE
KW - GENES
KW - HEMAGGLUTININ
KW - GLYCOPROTEINS
KW - INFLUENZA viruses
KW - ANTIGENIC determinants
N1 - Accession Number: 38614199; Adamo, Joan E. 1 Liu, Teresa 1 Schmeisser, Falko 1 Zhiping Ye 1; Email Address: zhiping.ye@fda.hhs.gov; Affiliation: 1: Division of Viral Products, CBER, U.S. Food and Drug Administration, Bethesda, Maryland 20892; Source Info: May2009, Vol. 83 Issue 9, p4203; Subject Term: VIRAL proteins; Subject Term: NEURAMINIDASE; Subject Term: GENES; Subject Term: HEMAGGLUTININ; Subject Term: GLYCOPROTEINS; Subject Term: INFLUENZA viruses; Subject Term: ANTIGENIC determinants; Number of Pages: 7p; Document Type: Article
L3 - 10.1128/JVI.02391-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38614199&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Laddy, Dominick J.
AU - Jian Yan
AU - Khan, Amir S.
AU - Andersen, Hanne
AU - Cohn, Amanda
AU - Greenhouse, Jack
AU - Lewis, Mark
AU - Manischewitz, Jody
AU - King, Lisa R.
AU - Golding, Hana
AU - Draghia-Akli, Ruxandra
AU - Weiner, David B.
T1 - Electroporation of Synthetic DNA Antigens Offers Protection in Nonhuman Primates Challenged with Highly Pathogenic Avian Influenza Virus.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/05//
VL - 83
IS - 9
M3 - Article
SP - 4624
EP - 4630
SN - 0022538X
AB - Avian influenza highlights the need for novel vaccination techniques that would allow for the rapid design and production of safe and effective vaccines. An ideal platform would be capable of inducing both protective antibodies and potent cellular immune responses. These potential advantages of DNA vaccines remain unrealized due to a lack of efficacy in large animal studies and in human trials. Questions remain regarding the potential utility of cellular immune responses against influenza virus in primates. In this study, by construct optimization and in vivo electroporation of synthetic DNA-encoded antigens, we observed the induction of cross-reactive cellular and humoral immune responses individually capable of providing protection from influenza virus infection in the rhesus macaque. These studies advance the DNA vaccine field and provide a novel, more tolerable vaccine with broad immunogenicity to avian influenza virus. This approach appears important for further investigation, including studies with humans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ELECTROPORATION
KW - DNA
KW - ANTIGENS
KW - INFLUENZA viruses
KW - VACCINATION
KW - IMMUNE response
KW - IMMUNOGLOBULINS
KW - GENETICS
N1 - Accession Number: 38614204; Laddy, Dominick J. 1 Jian Yan 1 Khan, Amir S. 2 Andersen, Hanne 3 Cohn, Amanda 3 Greenhouse, Jack 3 Lewis, Mark 3 Manischewitz, Jody 4 King, Lisa R. 4 Golding, Hana 4 Draghia-Akli, Ruxandra 2 Weiner, David B. 1; Email Address: dbweiner@mail.med.upenn.edu; Affiliation: 1: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 2: VGX Pharmaceuticals, Inc., Woodlands, Texas 77381 3: Bioqual, Inc., Rockville, Maryland 20850 4: U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Viral Products, Bethesda, Maryland 20892; Source Info: May2009, Vol. 83 Issue 9, p4624; Subject Term: ELECTROPORATION; Subject Term: DNA; Subject Term: ANTIGENS; Subject Term: INFLUENZA viruses; Subject Term: VACCINATION; Subject Term: IMMUNE response; Subject Term: IMMUNOGLOBULINS; Subject Term: GENETICS; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1128/JVI.02335-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38614204&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - González, Jaime Fernando
AU - Reimschuessel, Renate
AU - Shaikh, Badar
AU - Kane, Andrew S.
T1 - Kinetics of hepatic phase I and II biotransformation reactions in eight finfish species
JO - Marine Environmental Research
JF - Marine Environmental Research
Y1 - 2009/05//
VL - 67
IS - 4/5
M3 - Article
SP - 183
EP - 188
SN - 01411136
AB - Hepatic microsomes and cytosols of channel catfish (Ictalurus punctatus), rainbow trout (Oncorhynchus mykiss), Atlantic salmon (Salmo salar), red tilapia (Oreochromis sp.), largemouth bass (Micropterus salmoides), striped bass (Morone saxatilis), hybrid striped bass (M. saxatilis × M. crysops), and bluegill (Lepomis macrochuris) (n =8) were used to study the kinetics of phase I (ECOD, EROD, PROD, BROD) and phase II (UDP-glucuronosyltransferase (UDPGT)-, sulfotransferase (ST)- and glutathione-s-transferase (GST)-mediated) reactions. The best catalytic efficiency for ECOD and GST activities was performed by channel catfish, Atlantic salmon, rainbow trout and tilapia. The highest EROD catalytic efficiency was for Atlantic salmon. None of the species had either PROD or BROD activities. Rainbow trout had very similar UDPGT catalytic efficiency to tilapia, channel catfish, Atlantic salmon, largemouth bass and bluegill. Sulfotransferase conjugation had no significant differences among the species. In summary, tilapia, channel catfish, Atlantic salmon and rainbow trout had the best biotransforming capabilities; striped bass, hybrid striped bass and bluegill were low metabolizers and largemouth bass shared some capabilities with both groups. [Copyright &y& Elsevier]
AB - Copyright of Marine Environmental Research is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOTRANSFORMATION (Metabolism)
KW - RESEARCH
KW - FISH physiology
KW - FISH metabolism
KW - PHARMACOKINETICS
KW - TRANSFERASES
KW - METABOLIC detoxification
KW - RAINBOW trout
KW - BASSES (Fish)
KW - ATLANTIC salmon
KW - TILAPIA
KW - Finfish
KW - Hepatic
KW - Kinetics
KW - Phase I and II biotransformation reactions
N1 - Accession Number: 39782552; González, Jaime Fernando 1; Email Address: jaimefgonzalez@gmail.com Reimschuessel, Renate 2 Shaikh, Badar 2 Kane, Andrew S. 3; Affiliation: 1: School of Veterinary Medicine and Animal Science, Universidad Nacional de Colombia, AA 146224 Bogotá, Colombia 2: Center for Veterinary Medicine, Food Drug Administration (USFDA), Laurel, MD, USA 3: College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA; Source Info: May2009, Vol. 67 Issue 4/5, p183; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: RESEARCH; Subject Term: FISH physiology; Subject Term: FISH metabolism; Subject Term: PHARMACOKINETICS; Subject Term: TRANSFERASES; Subject Term: METABOLIC detoxification; Subject Term: RAINBOW trout; Subject Term: BASSES (Fish); Subject Term: ATLANTIC salmon; Subject Term: TILAPIA; Author-Supplied Keyword: Finfish; Author-Supplied Keyword: Hepatic; Author-Supplied Keyword: Kinetics; Author-Supplied Keyword: Phase I and II biotransformation reactions; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.marenvres.2009.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39782552&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105515698
T1 - Recent improvements in bariatric surgery outcomes.
AU - Encinosa WE
AU - Bernard DM
AU - Du D
AU - Steiner CA
Y1 - 2009/05//2009 May
N1 - Accession Number: 105515698. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Bariatric Surgery -- Economics
KW - Bariatric Surgery -- Methods
KW - Postoperative Complications -- Epidemiology
KW - Quality of Health Care
KW - Adolescence
KW - Adult
KW - Female
KW - Insurance -- Statistics and Numerical Data
KW - Laparoscopy -- Utilization
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Obesity -- Surgery
KW - Readmission
KW - Risk Assessment
KW - Treatment Outcomes
KW - United States
KW - Human
SP - 531
EP - 535
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Bariatric surgery is one of the fastest growing hospital procedures, but with a 40% complication rate in 2001. Between 2001 and 2005 bariatric surgeries grew by 113%. Our objective is to examine how 6-month complications improved between 2001 and 2006, using a nationwide, population-based sample. DATA/DESIGN: We examined insurance claims in 2001-2002 and 2005-2006 for 9582 bariatric surgeries, at 652 hospitals, among a population of 16 million non-elderly people. Outcomes and costs were risk-adjusted using multivariate regression methods with hospital fixed effects. PRINCIPAL FINDINGS: Between 2001 and 2006, while older and sicker patients underwent the surgery, the 180-day risk-adjusted complication rate declined 21% from 41.7% to 32.8%. Most of the improvement was in the initial hospital stay, where the risk-adjusted inpatient complication rate declined 37%, from 23.6% to 14.8%. Risk-adjusted rates of readmissions with complications declined 31%, from 9.8% to 6.8%. Risk-adjusted hospital days declined from 6 to 3.7 days, and risk-adjusted and inflation-adjusted payments declined 6%.Improvements in complication rates and readmission rates were associated with a within-hospital 30% increase in hospital volume. Volume had no impact on costs. The use of laparoscopy, which increased from 9% to 71%, reduced costs by 12%, while gastric banding decreased costs by 20%. Laparoscopy had no impact on readmissions, but the increase in banding without bypass reduced readmissions. CONCLUSIONS: Improvements in bariatric outcomes and costs were due to a mix of within-hospital volume increases, a move to a laparoscopic technique, and an increase in banding without bypass.
SN - 0025-7079
AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA. wencinos@ahrq.gov
U2 - PMID: 19318997.
DO - 10.1097/MLR.0b013e31819434c6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105515698&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105515084
T1 - Do patient safety events increase readmissions?
AU - Friedman B
AU - Encinosa W
AU - Jiang HJ
AU - Mutter R
Y1 - 2009/05//2009 May
N1 - Accession Number: 105515084. Language: English. Entry Date: 20090529. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Quality of Health Care
KW - Readmission -- Trends
KW - Safety
KW - Treatment Errors
KW - Adolescence
KW - Adult
KW - Aged
KW - Databases
KW - Female
KW - Hospital Mortality
KW - Male
KW - Middle Age
KW - Models, Theoretical
KW - United States
KW - Human
SP - 583
EP - 590
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 5
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE:: Adverse safety events in the hospital could impose extra costs not only due to longer stays and corrective treatments, but also due to deaths and readmissions. The effects of safety events on readmissions have rarely been analyzed. Large, all-payer and all-diagnosis databases permit new tests. This study will simultaneously test the effects of safety events on risks of deaths and readmission. STUDY DESIGN:: The population is a selection of almost 1.5 million adult surgery patients initially treated in 1088 short stay hospitals. These are patients at risk for at least 1 of 9 types of patient safety event, as specified in software in the public domain from the Agency for Healthcare Research and Quality. The main data sources are 7 statewide databases of hospitalizations in 2004, maintained by Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. We control for many factors affecting readmission or death, particularly the severity of illness, chronic comorbidities, age, and payer group. Separate models are used for each type of safety event and a composite model is used for any safety event. PRINCIPAL FINDINGS:: Among the patients at risk for any of the patient safety events, 2.6% had at least one safety event. The 3-month readmission rate was about 17% for those with no safety event, but about 25% when a safety event was recorded. The corresponding rates for readmission within 1 month were 11% and 16%. The in-hospital death rate was 1.3% with no safety event, but 9.2% with a safety event. After risk adjustment, the relative risk of readmission within 3 months was about 1.20 (P < 0.01), ranging from 1.14 to 1.56 for specific types of events. The risk-adjusted result for readmission within 1 month associated with at least one safety event was 1.17 (P < 0.01). However, the models for specific safety events gave a significantly high risk of readmission within 1 month for only 2 of the more common types of safety events. CONCLUSIONS:: Hospital readmissions are one way that safety events can have costly consequences. More attention is warranted to assess the full extra cost of safety events, the factors influencing the rate of safety events, and strategies for health plans to improve incentives for safety.
SN - 0025-7079
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 19318996.
DO - 10.1097/MLR.0b013e31819434da
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105515084&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schmerk, Crystal L.
AU - Duplantis, Barry N.
AU - Wang, Diana
AU - Burke, Robert D.
AU - Chou, Alicia Y.
AU - Elkins, Karen L.
AU - Ludu, Jagjit S.
AU - Nano, Francis E.
T1 - Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella no vicida.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2009/05//
VL - 155
IS - 5
M3 - Article
SP - 1489
EP - 1497
SN - 13500872
AB - The article presents a study on Francisella tularensis virulence factors for tularemia disease in mice and human. The study shows that the gene regulation of Francisella pathogenicity island (FPI) gene expression has been connected to Francisella species. The study also explores the primary properties of pathogenicity determinant protein A (PdpA) protein expression and localization. It states that PdpA deletion has also followed a strain that highly reduced virulence factors in both chicken embryos and mice.
KW - Virulence (Microbiology)
KW - Animal models in research
KW - Bacteriophages
KW - Francisella tularensis
KW - Tularemia -- Treatment
KW - Mice as laboratory animals
KW - Gene expression
KW - Protein binding
KW - Biochemical research
N1 - Accession Number: 41528399; Schmerk, Crystal L. 1; Duplantis, Barry N. 1; Wang, Diana 1; Burke, Robert D. 1; Chou, Alicia Y. 2; Elkins, Karen L. 2; Ludu, Jagjit S. 1; Nano, Francis E. 1; Email Address: fnano@uvic.ca; Affiliations: 1: Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: May2009, Vol. 155 Issue 5, p1489; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Animal models in research; Thesaurus Term: Bacteriophages; Subject Term: Francisella tularensis; Subject Term: Tularemia -- Treatment; Subject Term: Mice as laboratory animals; Subject Term: Gene expression; Subject Term: Protein binding; Subject Term: Biochemical research; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1099/mic.0.025379-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=41528399&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chae, Myounghee
AU - Rhee, Gyu-Seek
AU - Jang, Ik-Soon
AU - Kim, Kwangsoo
AU - Lee, Ji-Hae
AU - Lee, Seung-Yeul
AU - Kim, Minjung
AU - Yang, Junyoung
AU - Park, Junsoo
AU - Lee, Seung-Hoon
T1 - ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells.
JO - Molecules & Cells (Springer Science & Business Media B.V.)
JF - Molecules & Cells (Springer Science & Business Media B.V.)
Y1 - 2009/05//
VL - 27
IS - 5
M3 - Article
SP - 571
EP - 575
PB - Springer Science & Business Media B.V.
SN - 10168478
AB - The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecules & Cells (Springer Science & Business Media B.V.) is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Atg5
KW - autophagy
KW - MDMA
KW - neuron
KW - PC12
KW - SH-SY5Y
N1 - Accession Number: 71778666; Chae, Myounghee 1 Rhee, Gyu-Seek 2 Jang, Ik-Soon 1 Kim, Kwangsoo 1 Lee, Ji-Hae 3 Lee, Seung-Yeul 3 Kim, Minjung 3 Yang, Junyoung 2 Park, Junsoo 4; Email Address: junsoo@yonsei.ac.kr Lee, Seung-Hoon 3; Email Address: shlee@yongin.ac.kr; Affiliation: 1: Korea Basic Science Institute , Gwangju Center , Gwangju 500-757 Korea 2: Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research , Korea Food and Drug Administration , Seoul 122-704 Korea 3: Department of Biological Sciences , Yong-In University , Yongin 449-719 Korea 4: Division of Biological Sciences and Technology , Yonsei University , Wonju 220-100 Korea; Source Info: May2009, Vol. 27 Issue 5, p571; Author-Supplied Keyword: Atg5; Author-Supplied Keyword: autophagy; Author-Supplied Keyword: MDMA; Author-Supplied Keyword: neuron; Author-Supplied Keyword: PC12; Author-Supplied Keyword: SH-SY5Y; Number of Pages: 5p; Document Type: Article
L3 - 10.1007/s10059-009-0075-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=71778666&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ling Peng
AU - Yajun Guo
AU - Yun Zhou
AU - Jianxin Dai
AU - Hao Wang
T1 - Inhibition of Breast Cancer Metastasis and Angiogenesis by Antiosteopontin Single-Chain Fv-Fc Fusion Protein.
JO - Neoplasia
JF - Neoplasia
Y1 - 2009/05//
VL - 11
IS - 5
M3 - Article
SP - 509
EP - 519
SN - 15228002
AB - Osteopontin (OPN) is associated with many diseases, and its role in tumor growth and metastasis has been studied in breast cancers. Previous studies have described anti-OPN antibodies that could inhibit tumor cell adhesion and invasion in vitro, but until now, there are no systematic studies on antitumor effects of anti-OPN antibodies in vivo. In the present study, we have raised several anti-OPN single-chain variable fragments from phage antibody library and expressed them as single-chain variable fragment--constant region fragment fusion proteins in Chinese hamster ovary cells. Of them, two antibodies (1A12 and 2H8) were able to inhibit MDA-MB-435s breast cancer cell attachment, invasion, migration, and colony formation in soft agar. Furthermore, 1A12 and 2H8 inhibited the antiapoptotic and prosurvival functions of OPN in human umbilical vein endothelial cell. In human umbilical vein endothelial cell capillary tube formation, chicken chorioallantoic membrane assay, and rabbit corneal micropocket assay, the two antibodies showed markedly inhibitory effects toward angiogenesis. We investigated antitumor effects of anti-OPN antibodies in nude mice by assessing xenograft tumor growth and lung metastasis potential. The results showed that the two antibodies were capable of delaying primary tumor growth and reducing spontaneous lung metastasis. Epitope mappings of these two anti-OPN antibodies were performed, and a new binding site of 1A12 was revealed. In summary, the present study has demonstrated the roles of anti-OPN antibodies in blocking the function of OPN, suggesting that they may have the potential to be developed for future clinical use. [ABSTRACT FROM AUTHOR]
AB - Copyright of Neoplasia is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METASTASIS
KW - NEOVASCULARIZATION
KW - OSTEOPONTIN
KW - CELL adhesion
KW - CANCER cell growth -- Regulation
KW - BREAST cancer
KW - TUMOR suppressor proteins
N1 - Accession Number: 38994792; Ling Peng 1,2; Email Address: dr.pengling@gmail.com Yajun Guo 2 Yun Zhou 3 Jianxin Dai 2 Hao Wang 2; Affiliation: 1: Department of Medicinal Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province 210002, People's Republic of China 2: Shanghai International Joint Cancer Institute, Second Military Medical University, Shanghai 200433, People's Republic of China 3: Zhejiang Food and Drug Administration, Hangzhou, Zhejiang Province 310012, People's Republic of China; Source Info: May2009, Vol. 11 Issue 5, p509; Subject Term: METASTASIS; Subject Term: NEOVASCULARIZATION; Subject Term: OSTEOPONTIN; Subject Term: CELL adhesion; Subject Term: CANCER cell growth -- Regulation; Subject Term: BREAST cancer; Subject Term: TUMOR suppressor proteins; Number of Pages: 11p; Illustrations: 4 Diagrams, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1593/neo.81622
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ferguson, Sherry A.
AU - Delclos, K. Barry
AU - Newbold, Retha R.
AU - Flynn, Katherine M.
T1 - Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague–Dawley rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/05//
VL - 31
IS - 3
M3 - Article
SP - 143
EP - 148
SN - 08920362
AB - Abstract: Previous work in our laboratory indicated that lifelong dietary exposure to estrogen-like endocrine disrupters increased sodium solution intake in adult male and female rats. Here, we sought to discern the critical periods necessary for this alteration as well as establish the effects of lower dietary concentrations of genistein and nonylphenol. Male and female Sprague–Dawley rats (F0) consumed phytoestrogen-free chow containing 0, 5, 100, or 500 ppm genistein (≈0.0, 0.4, 8.0, and 40.0 mg/kg/day) or 0, 25, 200, or 750 ppm nonylphenol (≈0.0, 2.0, 16.0, and 60.0 mg/kg/day). Rats were mated within treatment groups and offspring (F1) maintained on the same diets. Mating for the F1, F2, and F3 (genistein only) was within treatment groups. At postnatal day (PND) 21, the F3 generation began to consume unadulterated phytoestrogen-free chow such that genistein exposure occurred only in utero and preweaning. The F4 generation was never directly exposed to genistein. On PNDs 65–68, intake of regular water and a 3.0% sodium chloride solution was measured for F1–F4 generations (genistein portion) or F1–F2 (nonylphenol portion). Although body weights were decreased by the highest dietary concentrations of genistein and nonylphenol, there were only minimal effects of exposure on sodium solution intake. As expected, intake was highest in female rats. With previous data, these results indicate that the dietary concentrations necessary to increase adult sodium solution intake in rats are greater than 500 ppm genistein and 750 ppm nonylphenol and such effects do not appear to increase across generations. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BODY weight
KW - WEIGHTS & measures
KW - ANTHROPOMETRY
KW - BODY size
KW - Endocrine disrupter
KW - Genistein
KW - Nonylphenol
KW - Rat
KW - Sodium
N1 - Accession Number: 38319974; Ferguson, Sherry A. 1; Email Address: Sherry.Ferguson@fda.hhs.gov Delclos, K. Barry 2 Newbold, Retha R. 3 Flynn, Katherine M. 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States 2: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States 3: Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States; Source Info: May2009, Vol. 31 Issue 3, p143; Subject Term: BODY weight; Subject Term: WEIGHTS & measures; Subject Term: ANTHROPOMETRY; Subject Term: BODY size; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Nonylphenol; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Sodium; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ntt.2009.01.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38319974&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ferguson, Sherry A.
AU - Delclos, K. Barry
AU - Newbold, Retha R.
AU - Flynn, Katherine M.
T1 - Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague–Dawley rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/05//
VL - 31
IS - 3
M3 - Article
SP - 143
EP - 148
SN - 08920362
AB - Abstract: Previous work in our laboratory indicated that lifelong dietary exposure to estrogen-like endocrine disrupters increased sodium solution intake in adult male and female rats. Here, we sought to discern the critical periods necessary for this alteration as well as establish the effects of lower dietary concentrations of genistein and nonylphenol. Male and female Sprague–Dawley rats (F0) consumed phytoestrogen-free chow containing 0, 5, 100, or 500 ppm genistein (≈0.0, 0.4, 8.0, and 40.0 mg/kg/day) or 0, 25, 200, or 750 ppm nonylphenol (≈0.0, 2.0, 16.0, and 60.0 mg/kg/day). Rats were mated within treatment groups and offspring (F1) maintained on the same diets. Mating for the F1, F2, and F3 (genistein only) was within treatment groups. At postnatal day (PND) 21, the F3 generation began to consume unadulterated phytoestrogen-free chow such that genistein exposure occurred only in utero and preweaning. The F4 generation was never directly exposed to genistein. On PNDs 65–68, intake of regular water and a 3.0% sodium chloride solution was measured for F1–F4 generations (genistein portion) or F1–F2 (nonylphenol portion). Although body weights were decreased by the highest dietary concentrations of genistein and nonylphenol, there were only minimal effects of exposure on sodium solution intake. As expected, intake was highest in female rats. With previous data, these results indicate that the dietary concentrations necessary to increase adult sodium solution intake in rats are greater than 500 ppm genistein and 750 ppm nonylphenol and such effects do not appear to increase across generations. [Copyright &y& Elsevier]
AB - Copyright of Neurotoxicology & Teratology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Weights & measures
KW - Body weight
KW - Anthropometry
KW - Body size
KW - Endocrine disrupter
KW - Genistein
KW - Nonylphenol
KW - Rat
KW - Sodium
N1 - Accession Number: 38319974; Ferguson, Sherry A. 1; Email Address: Sherry.Ferguson@fda.hhs.gov; Delclos, K. Barry 2; Newbold, Retha R. 3; Flynn, Katherine M. 1; Affiliations: 1: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States; 2: Division of Biochemical Toxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States; 3: Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States; Issue Info: May2009, Vol. 31 Issue 3, p143; Thesaurus Term: Weights & measures; Subject Term: Body weight; Subject Term: Anthropometry; Subject Term: Body size; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Nonylphenol; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Sodium; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ntt.2009.01.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hayden, Charles S.
AU - Zechmann, Edward L.
T1 - Relevant test methods for establishing sound power levels of powered hand tools.
JO - Noise Control Engineering Journal
JF - Noise Control Engineering Journal
Y1 - 2009/05//May/Jun2009
VL - 57
IS - 3
M3 - Article
SP - 279
EP - 290
PB - Institute of Noise Control Engineering of the USA
SN - 07362501
AB - High rates of noise induced hearing loss among construction workers provides the motivation for providing noise exposure level information to users and purchasers of powered hand tools. This paper describes relevant sound power level test methods necessary to estimate a tool user's noise exposure. The data are summarized here while detailed test results are posted on a National Institute for Occupational Safety and Health (NIOSH) website database, searchable by tool types, make, and model. The tools database also links directly to the NIOSH Hearing Protector Device Compendium, recommending the appropriate hearing protection for the given noise exposure. Measuring the sound power level in both the loaded and unloaded conditions and reporting the greater value is appropriate for the intended use of providing the relevant data to be used in making purchasing decisions and choosing correct hearing protection. While these researchers tested tools in both the loaded and unloaded conditions, much of the testing in the loaded condition required development of test jigs, methods, and procedures not detailed in existing test standards. It is recommended that efforts be initiated to develop standardized test jigs and methods, such as detailed here, so noise emission levels of power tools can be determined in a relevant and uniform manner from lab to lab. [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Control Engineering Journal is the property of Institute of Noise Control Engineering of the USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - HEALTH
KW - Power tools -- Evaluation
KW - Noise control
KW - Acoustical engineering
KW - Sound measurement -- Equipment & supplies
KW - Physical measurements -- Equipment & supplies
KW - Testing
KW - Standards
KW - Engineering standards
KW - Measuring instruments
KW - Decibels
KW - Deafness -- Risk factors
KW - Construction workers
KW - Hearing protection
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 49222897; Hayden, Charles S. 1; Email Address: CHayden@cdc.gov; Zechmann, Edward L. 1; Email Address: EZechmann@cdc.gov; Affiliations: 1: National Institute of Occupational Safety and Health, 4676 Columbia Parkway C27, Cincinnati OH 45226.; Issue Info: May/Jun2009, Vol. 57 Issue 3, p279; Thesaurus Term: RESEARCH; Thesaurus Term: HEALTH; Subject Term: Power tools -- Evaluation; Subject Term: Noise control; Subject Term: Acoustical engineering; Subject Term: Sound measurement -- Equipment & supplies; Subject Term: Physical measurements -- Equipment & supplies; Subject Term: Testing; Subject Term: Standards; Subject Term: Engineering standards; Subject Term: Measuring instruments; Subject Term: Decibels; Subject Term: Deafness -- Risk factors; Subject Term: Construction workers; Subject Term: Hearing protection ; Company/Entity: National Institute for Occupational Safety & Health; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 333991 Power-Driven Handtool Manufacturing; Number of Pages: 12p; Illustrations: 3 Color Photographs, 18 Diagrams, 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - dos Santos Antao, V. C.
AU - Pinheiro, G. A.
AU - Wassell, J. T.
T1 - Asbestosis mortality in the USA: facts and predictions.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2009/05//
VL - 66
IS - 5
M3 - Article
SP - 10
EP - 10
SN - 13510711
AB - Background: Mortality trends in the USA show that deaths from asbestosis are increasing, while deaths related to other pneumoconiosis are declining. Objectives: To analyse the association between asbestos consumption and asbestosis mortality trends. Methods: In an epidemiological time series study, we used a modern computer-intensive local regression method to evaluate the relationship between asbestos consumption per capita (1900-2006) as the predictor variable and number of deaths from asbestosis (1968-2004). The predictor variable was progressively lagged by annual increments from 30 to 60 years and the goodness of fit assessed for each lag period. The model having the smallest Akaike's Information Criteria was used to derive extrapolated estimates of future mortality based on more recent asbestos consumption data. Results: Asbestos consumption per capita reached a peak in 1951 and gradually declined until 1973, when it started to drop rapidly. In 2006, it was 0.0075 kg/person/year. There were 25 564 deaths from asbestosis over the period 1968-2004. The best-fitting model (adjusted coefficient of determination (R2) = 99.7%) for 1968-2004 deaths from asbestosis used asbestos consumption per capita 48 years prior (1920-1956) and the log value of asbestos consumption per capita 43 years prior (1925-1961). This model predicts a total of 29 667 deaths (95% CI 19 629 to 39 705) to occur during 2005-2027 (an average of 1290 deaths per year). Conclusions: This study demonstrates a clear association between asbestos consumption and deaths from asbestosis and indicates that asbestosis deaths are not expected to decrease sharply in the next 10-15 years. [ABSTRACT FROM AUTHOR]
AB - Copyright of Occupational & Environmental Medicine is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asbestosis
KW - Asbestos
KW - Mortality
KW - Lungs -- Dust diseases
KW - Consumption (Economics)
KW - United States
N1 - Accession Number: 39895363; dos Santos Antao, V. C. 1; Email Address: VAntao@cdc.gov; Pinheiro, G. A. 1; Wassell, J. T. 2; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; 2: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: May2009, Vol. 66 Issue 5, p10; Thesaurus Term: Asbestosis; Thesaurus Term: Asbestos; Subject Term: Mortality; Subject Term: Lungs -- Dust diseases; Subject Term: Consumption (Economics); Subject: United States; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; Number of Pages: 1p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105350104
T1 - Practice pointers. Reduce the risk of skin burns.
AU - Mirsaidi N
Y1 - 2009/05//2009 May
N1 - Accession Number: 105350104. Language: English. Entry Date: 20090703. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Double Blind Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 101308226.
KW - Burns -- Prevention and Control
KW - Lighting
KW - Microsurgery
KW - Microscopy
KW - Minimally Invasive Procedures
SP - 56
EP - 56
JO - OR Nurse
JF - OR Nurse
JA - OR NURSE
VL - 3
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1933-3145
AD - Center for Devices and Radiological Health, Rockville, MD
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Mudano, A. S.
AU - Bian, J.
AU - Cope, J. U.
AU - Curtis, J. R.
AU - Gross, T. P.
AU - Allison, J. J.
AU - Kim, Y.
AU - Briggs, D.
AU - Melton, M. E.
AU - Xi, J.
AU - Saag, K. G.
T1 - Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: a population-based cohort study.
JO - Osteoporosis International
JF - Osteoporosis International
Y1 - 2009/05//
VL - 20
IS - 5
M3 - Article
SP - 819
EP - 826
SN - 0937941X
AB - To better understand the risk of secondary vertebral compression fracture (VCF) following a vertebroplasty or kyphoplasty, we compared patients treated with those procedures to patients with a previous VCF. The risk of subsequent fracture was significantly greater among treatment patients, especially within 90 days of the procedure. Predominantly uncontrolled studies suggest a greater risk of subsequent vertebral compression fractures (VCFs) associated with vertebroplasty/kyphoplasty. To further understand this risk, we conducted a population-based retrospective cohort study using data from a large regional health insurer. Administrative claims procedure codes were used to identify patients receiving either a vertebroplasty or kyphoplasty (treatment group) and a comparison group of patients with a primary diagnosis of VCF who did not receive treatment during the same time period. The main outcomes of interest, validated by two independent medical record reviewers, were any new VCFs within (1) 90 days, (2) 360 days, and (3) at adjacent vertebral levels. Multivariable logistic regression examined the association of vertebroplasty/kyphoplasty with new VCFs. Among 48 treatment (51% vertebroplasty, 49% kyphoplasty) and 164 comparison patients, treated patients had a significantly greater risk of secondary VCFs than comparison patients for fractures within 90 days of the procedure or comparison group time point [adjusted odds ratio (OR) = 6.8; 95% confidence interval (CI) 1.7–26.9] and within 360 days (adjusted OR = 2.9; 95% CI 1.1–7.9). Patients who had undergone vertebroplasty/kyphoplasty had a greater risk of new VCFs compared to patients with prior VCFs who did not undergo either procedure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Osteoporosis International is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE cements
KW - OSTEOPOROSIS -- Treatment
KW - VERTEBRAE -- Abnormalities
KW - COHORT analysis
KW - FRACTURES
KW - Bone cement
KW - Kyphoplasty
KW - Osteoporosis
KW - Population-based
KW - Vertebral compression fractures
KW - Vertebroplasty
N1 - Accession Number: 37268277; Mudano, A. S. 1,2 Bian, J. 1,3 Cope, J. U. 4 Curtis, J. R. 1 Gross, T. P. 4 Allison, J. J. 1 Kim, Y. 1 Briggs, D. 2 Melton, M. E. 1 Xi, J. 1 Saag, K. G. 1; Email Address: ksaag@uab.edu; Affiliation: 1: Center for Education & Research on Therapeutics (CERTs) of Musculoskeletal Disorders, University of Alabama at Birmingham, 510 - 20th Street South, 820 FOT, Birmingham, AL 35294-3408, USA 2: Health Management, Blue Cross and Blue Shield of Alabama, Birmingham, AL, USA 3: Atlanta Veteran Affairs Medical Center, Atlanta, GA, USA 4: Center for Devices and Radiological Health, Food and Drug Administration, Office of Surveillance and Biometrics, Rockville, MD, USA; Source Info: May2009, Vol. 20 Issue 5, p819; Subject Term: BONE cements; Subject Term: OSTEOPOROSIS -- Treatment; Subject Term: VERTEBRAE -- Abnormalities; Subject Term: COHORT analysis; Subject Term: FRACTURES; Author-Supplied Keyword: Bone cement; Author-Supplied Keyword: Kyphoplasty; Author-Supplied Keyword: Osteoporosis; Author-Supplied Keyword: Population-based; Author-Supplied Keyword: Vertebral compression fractures; Author-Supplied Keyword: Vertebroplasty; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s00198-008-0745-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tromp, M.
AU - van Eijsden, M.
AU - Ravelli, A. C. J.
AU - Bonsel, G. J.
T1 - Anonymous non-response analysis in the ABCD cohort study enabled by probabilistic record linkage.
JO - Paediatric & Perinatal Epidemiology
JF - Paediatric & Perinatal Epidemiology
Y1 - 2009/05//
VL - 23
IS - 3
M3 - Article
SP - 264
EP - 272
PB - Wiley-Blackwell
SN - 02695022
AB - Selective non-response is an important threat to study validity as it can lead to selection bias. The Amsterdam Born Children and their Development study (ABCD-study) is a large cohort study addressing the relationship between life style, psychological conditions, nutrition and sociodemographic background of pregnant women and their children's health. Possible selective non-response and selection bias in the ABCD-study were analysed using national perinatal registry data. ABCD-study data were linked with national perinatal registry data by probabilistic medical record linkage techniques. Differences in the prevalence of relevant risk factors (sociodemographic and care-related factors) and birth outcomes between respondents and non-respondents were tested using Pearson chi-squared tests. Selection bias (i.e. bias in the association between risk factors and specific outcomes) was analysed by regression analysis with and without adjustment for participation status. The ABCD non-respondents were significantly younger, more often non-western, and more often multiparae. Non-respondents entered antenatal care later, were more often under supervision of an obstetrician and had a spontaneous delivery more often. Non-response however, was not significantly associated with preterm birth (odds ratio 1.10; 95% CI 0.93, 1.29) or low birthweight (odds ratio 1.16; 95% CI 0.98, 1.37) after adjustment for sociodemographic risk factors. The associations found between risk factors and adverse pregnancy outcomes were similar for respondents and non-respondents. Anonymised record linkage of cohort study data with national registry data indicated that selective non-response was present in the ABCD-study, but selection bias was acceptably low and did not influence the main study questions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Paediatric & Perinatal Epidemiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIFESTYLES
KW - PREGNANT women -- Health
KW - NUTRITION in pregnancy
KW - MEDICAL records
KW - REGRESSION analysis
KW - cohort study
KW - medical record linkage
KW - non-response
KW - perinatal care
KW - selection bias
N1 - Accession Number: 37208584; Tromp, M. 1; Email Address: m.tromp@amc.uva.nl van Eijsden, M. 2,3 Ravelli, A. C. J. 1 Bonsel, G. J. 2,4; Affiliation: 1: Department of Medical Informatics, Public Health Service, Amsterdam 2: Public Health Epidemiology, Academic Medical Center (AMC), Public Health Service, Amsterdam 3: Department of Epidemiology, Documentation and Health Promotion, Public Health Service, Amsterdam 4: Department of Health Policy and Management, Erasmus Medical Center, Rotterdam, the Netherlands; Source Info: May2009, Vol. 23 Issue 3, p264; Subject Term: LIFESTYLES; Subject Term: PREGNANT women -- Health; Subject Term: NUTRITION in pregnancy; Subject Term: MEDICAL records; Subject Term: REGRESSION analysis; Author-Supplied Keyword: cohort study; Author-Supplied Keyword: medical record linkage; Author-Supplied Keyword: non-response; Author-Supplied Keyword: perinatal care; Author-Supplied Keyword: selection bias; Number of Pages: 9p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1111/j.1365-3016.2009.01030.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Hainan
AU - Ye, Xiaofei
AU - Gao, Qingbin
AU - Wu, Cheng
AU - Qian, Yifeng
AU - Luo, Baozhang
AU - Sun, Yalin
AU - He, Jia
T1 - Pharmacovigilance in traditional chinese medicine safety surveillance.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/05//
VL - 18
IS - 5
M3 - Article
SP - 357
EP - 361
SN - 10538569
AB - Purpose To give an overview of the current status including problems and efforts about pharmacovigilance in Traditional Chinese Medicine (TCM) safety surveillance. Methods It is based on literature review and publicly available data in China. Results TCM led to several adverse drug reactions (ADRs) during the past few years and pharmacovigilance about TCM remained as a problem though great effort had been made to improve it. Conclusions Pharmacovigilance in TCM is still facing many challenges in playing critical roles in China. More attention should be paid to pharmacovigilance in TCM safety surveillance. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707194; Wang, Hainan 1,2; Ye, Xiaofei 1; Gao, Qingbin 1; Wu, Cheng 1; Qian, Yifeng 1; Luo, Baozhang 1; Sun, Yalin 1; He, Jia 1; Affiliations: 1: Department of Health Statistics, Second Military Medical University, Shanghai, China; 2: Center for Drug Evaluation, State Food and Drug Administration, Beijing, China; Issue Info: May2009, Vol. 18 Issue 5, p357; Number of Pages: 5p; Document Type: Article
L3 - 10.1002/pds.1725
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cécile E. Duchesnes
T1 - New Zealand Ginger mouse: novel model that associates the tyrp1bpigmentation gene locus with regulation of lean body mass.
JO - Physiological Genomics
JF - Physiological Genomics
Y1 - 2009/05//
VL - 37
IS - 3
M3 - Article
SP - 164
EP - 174
SN - 10948341
AB - The study of spontaneous mutations in mice over the last century has been fundamental to our understanding of normal physiology and mechanisms of disease. Here we studied the phenotype and genotype of a novel mouse model we have called the New Zealand Ginger (NZG/Kgm) mouse. NZG/Kgm mice are very large, rapidly growing, ginger-colored mice with pink eyes. Breeding NZG/Kgm mice with CAST/Ei or C57BL/6J mice showed that the ginger coat colour is a recessive trait, while the excessive body weight and large body size exhibit a semidominant pattern of inheritance. Backcrossing F1 (NZG/Kgm x CAST/Ei) to NZG/Kgm mice to produce the N2 generation determined that the NZG/Kgm mouse has two recessive pigmentation variant genes (oca2pand tyrp-1b) and that the tyrp-1bgene locus associates with large body size. Three coat colors appeared in the N2 generation; ginger, brown, and dark. Strikingly, N2 male coat colour associated with body weight; the brown-colored mice weighed the most followed by ginger and then dark. The male brown coat-colored offspring reached adult body weights indistinguishable from NZG/Kgm males. The large NZG/Kgm mouse body size is a result of excessive lean body mass since these mice are not obese or diabetic. NZG/Kgm mice exhibit an unusual pattern of fat distribution; compared with other mouse strains they have disproportionately higher amounts of subcutaneous and gonadal fat. These mice are susceptible to high-fat diet-induced obesity but are resistant to high-fat diet-induced diabetes. We propose NZG/Kgm mice as a novel model to delineate gene(s) that regulate 1) growth and metabolism, 2) resistance to Type 2 diabetes, and 3) preferential fat deposition in the subcutaneous and gonadal areas. [ABSTRACT FROM AUTHOR]
AB - Copyright of Physiological Genomics is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-insulin-dependent diabetes
KW - MICE
KW - GENETIC polymorphisms
KW - NEW Zealand
N1 - Accession Number: 39988429; Cécile E. Duchesnes 1; Affiliation: 1: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Department of Paediatrics, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Department of Biomedical Imaging, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. The Jackson Laboratory, Bar Harbor, Maine. Division of Biomedical Toxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas; Source Info: May2009, Vol. 37 Issue 3, p164; Subject Term: NON-insulin-dependent diabetes; Subject Term: MICE; Subject Term: GENETIC polymorphisms; Subject Term: NEW Zealand; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yun Zhou
T1 - Effect of Triterpenoid Saponins from Bacopa monniera on Scopolamine-Induced Memory Impairment in Mice.
JO - Planta Medica
JF - Planta Medica
Y1 - 2009/05//
VL - 75
IS - 6
M3 - Article
SP - 568
EP - 574
SN - 00320943
AB - Three new saponins, bacopasides IX?XI ( 1- 3), together with their known analogues bacopaside I ( 4), bacopaside II ( 5), bacopasaponsin C ( 6), and bacopasaponsin D ( 7), were isolated from the whole plant of BACOPA MONNIERA. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice. [ABSTRACT FROM AUTHOR]
AB - Copyright of Planta Medica is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRITERPENOID saponins
KW - PLANTAGINACEAE
KW - SCOPOLAMINE
KW - MEMORY disorders
KW - MICE as laboratory animals
KW - PHYTOCHEMICALS
KW - NOOTROPIC agents
KW - DRUGS -- Physiological effect
N1 - Accession Number: 44026707; Yun Zhou 1; Affiliation: 1: Zhejiang Food and Drug Administration, Hangzhou, Zhejiang Province, P.?R. China; Source Info: May2009, Vol. 75 Issue 6, p568; Subject Term: TRITERPENOID saponins; Subject Term: PLANTAGINACEAE; Subject Term: SCOPOLAMINE; Subject Term: MEMORY disorders; Subject Term: MICE as laboratory animals; Subject Term: PHYTOCHEMICALS; Subject Term: NOOTROPIC agents; Subject Term: DRUGS -- Physiological effect; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105391692
T1 - Effect of triterpenoid saponins from Bacopa monniera on Scoplamine-induced memory impairment in mice.
AU - Zhou Y
AU - Peng L
AU - Zhang W
AU - Kong D
Y1 - 2009/05//
N1 - Accession Number: 105391692. Language: English. Entry Date: 20090925. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Alternative/Complementary Therapies; Biomedical; Continental Europe; Europe; Peer Reviewed. Grant Information: National Natural Science Foundation of China, by the Science and Technology Developing Foundation of Shanghai, and by the Program for Changjiang Scholars and Innovative Research Team in University. NLM UID: 0066751.
KW - Phytochemicals -- Analysis
KW - Phytochemicals -- Pharmacodynamics
KW - Plants, Medicinal
KW - Animal Studies
KW - Chromatography, Gas
KW - Chromatography, Liquid
KW - Funding Source
KW - Magnetic Resonance Spectroscopy
KW - Memory Disorders -- Chemically Induced
KW - Memory Disorders -- Prevention and Control
KW - Mice
KW - Molecular Structure
KW - One-Way Analysis of Variance
KW - Phytochemicals -- Therapeutic Use
KW - Scopolamine -- Administration and Dosage
KW - Mass Spectrometry
KW - T-Tests
SP - 568
EP - 574
JO - Planta Medica
JF - Planta Medica
JA - PLANTA MEDICA
VL - 75
IS - 6
PB - Georg Thieme Verlag Stuttgart
SN - 0032-0943
AD - Zhejiang Food and Drug Administration, Hangzhou, Zhejiang Province, P.R. China
U2 - PMID: 19214943.
DO - 10.1055/s-0029-1185339
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105391692&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105180772
T1 - Original research: Intravenous ribavirin--review of the FDA's Emergency Investigational New Drug Database (1997-2008) and literature review.
AU - Riner A
AU - Chan-Tack KM
AU - Murray JS
Y1 - 2009/05//2009 May
N1 - Accession Number: 105180772. Language: English. Entry Date: 20100430. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0401147.
KW - Antiviral Agents -- Administration and Dosage
KW - Drug Approval -- Methods
KW - Drugs, Investigational -- Administration and Dosage
KW - Ribavirin -- Administration and Dosage
KW - United States Food and Drug Administration
KW - Virus Diseases -- Drug Therapy
KW - Injections, Intravenous
KW - Treatment Outcomes
KW - United States
SP - 139
EP - 146
JO - Postgraduate Medicine
JF - Postgraduate Medicine
JA - POSTGRAD MED
VL - 121
IS - 3
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Intravenous (IV) ribavirin does not have US Food and Drug Administration (FDA) approval, although oral and aerosol formulations have been approved. Intravenous ribavirin can, however, be authorized for use as a result of an Emergency Investigational New Drug (EIND) application as investigational treatment for patients with serious viral infections, including emerging or rare infections for which no alternative treatment is available. This retrospective study evaluated clinical experience with IV ribavirin based on a review of the FDA's EIND database and a literature review. The main outcome measures were disease condition, clinical outcomes, and adverse events (AEs). First, the FDA's EIND database was evaluated for these variables among patients authorized to receive investigational IV ribavirin. Second, published literature on IV ribavirin was reviewed for diseases treated, reported clinical outcomes, and AEs. Adverse events reported in the literature were compared with AEs listed in approved product labeling (aerosol and oral formulations). From February 1997 to December 2008, 608 IV ribavirin EIND requests were made for 19 disease conditions. Adenovirus, respiratory syncytial virus, and parainfluenza infections comprised 84.7% of IV ribavirin EINDs. Inadequate reporting of clinical outcomes and AEs in the EIND database prevented analysis of either outcome. Data interpretation in the literature was limited by multiple factors, including retrospective design, small sample sizes, differences in reporting outcomes and AEs, lack of generalizability, and potential confounders such as concomitant medications, selection bias, and reporting bias. Reported AEs were consistent with labels of approved aerosol and oral formulations, except for lip and gingival swelling. However, estimates of frequency, severity, and causality of AEs associated with IV ribavirin could not be determined because of study limitations. Our study findings suggest that the literature is inconclusive on the potential benefit for continued use of IV ribavirin. A review of the literature and the FDA's EIND database suggests that prospective, controlled trials of IV ribavirin in patients with adenovirus, parainfluenza, or serious respiratory syncytial virus infections could be feasible.
SN - 0032-5481
AD - OND/DAVP, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
U2 - PMID: 19491552.
DO - 10.3810/pgm.2009.05.2014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105180772&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105389989
T1 - The 'RTR' medical response system for nuclear and radiological mass-casualty incidents: a functional TRiage-TReatment-TRansport Medical Response Model.
AU - Hrdina CM
AU - Coleman CN
AU - Bogucki S
AU - Bader JL
AU - Hayhurst RE
AU - Forsha JD
AU - Marcozzi D
AU - Yeskey K
AU - Knebel AR
Y1 - 2009/05//2009 May-Jun
N1 - Accession Number: 105389989. Language: English. Entry Date: 20090828. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Emergency Care. NLM UID: 8918173.
KW - Emergency Medical Service Communication Systems -- Evaluation
KW - Mass Casualty Incidents -- Prevention and Control
KW - Transportation of Patients -- Methods
KW - Triage
KW - Disasters -- Prevention and Control
KW - Mass Casualty Training -- Methods
KW - Nuclear Warfare
KW - Prehospital Care -- Methods
KW - Radiation Injuries -- Complications
KW - Radiation Safety
KW - United States Department of Homeland Security -- Standards
SP - 167
EP - 178
JO - Prehospital & Disaster Medicine
JF - Prehospital & Disaster Medicine
JA - PREHOSPITAL DISASTER MED
VL - 24
IS - 3
PB - Cambridge University Press
AB - Developing a mass-casualty medical response to the detonation of an improvised nuclear device (IND) or large radiological dispersal device (RDD) requires unique advanced planning due to the potential magnitude of the event, lack of warning, and radiation hazards. In order for medical care and resources to be collocated and matched to the requirements, a [US] Federal interagency medical response-planning group has developed a conceptual approach for responding to such nuclear and radiological incidents. The 'RTR' system (comprising Radiation-specific TRiage, TReatment, TRansport sites) is designed to support medical care following a nuclear incident. Its purpose is to characterize, organize, and efficiently deploy appropriate materiel and personnel assets as close as physically possible to various categories of victims while preserving the safety of responders. The RTR system is not a medical triage system for individual patients. After an incident is characterized and safe perimeters are established, RTR sites should be determined in real-time that are based on the extent of destruction, environmental factors, residual radiation, available infrastructure, and transportation routes. Such RTR sites are divided into three types depending on their physical/situational relationship to the incident. The RTR1 sites are near the epicenter with residual radiation and include victims with blast injuries and other major traumatic injuries including radiation exposure; RTR2 sites are situated in relationship to the plume with varying amounts of residual radiation present, with most victims being ambulatory; and RTR3 sites are collection and transport sites with minimal or no radiation present or exposure risk and a victim population with a potential variety of injuries or radiation exposures. Medical Care sites are predetermined sites at which definitive medical care is given to those in immediate need of care. They include local/regional hospitals, medical centers, other sites such as nursing homes and outpatient clinics, nationwide expert medical centers (such as cancer or burn centers), and possible alternate care facilities such as Federal Medical Stations. Assembly Centers for displaced or evacuating persons are predetermined and spontaneous sites safely outside of the perimeter of the incident, for use by those who need no immediate medical attention or only minor assistance. Decontamination requirements are important considerations for all RTR, Medical Care, and Assembly Center sites and transport vehicles. The US Department of Health and Human Services is working on a long-term project to generate a database for potential medical care sites and assembly centers so that information is immediately available should an incident occur.
SN - 1049-023X
AD - Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington DC
U2 - PMID: 19618351.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105532891
T1 - Focus on transformation: a public health model of mental health for the 21st century.
AU - Power AK
AU - Power, A Kathryn
Y1 - 2009/05//
N1 - Accession Number: 105532891. Language: English. Entry Date: 20090619. Revision Date: 20170307. Publication Type: journal article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9502838.
KW - Community Mental Health Services -- Administration -- United States
KW - Community Mental Health Services -- Methods
KW - Health Care Reform
KW - United States
SP - 580
EP - 584
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 60
IS - 5
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - In 2003 the President's New Freedom Commission called for the transformation of the public mental health system to one that is person centered, recovery focused, evidence based, and quality driven. In this column the director of the Center for Mental Health Services describes progress made by the center over the past five years as well as challenges and opportunities. She presents a strategic forecast, based on stakeholder input, to guide policy formulation and resource allocation. Central to the forecast is the concept of a public health model of mental health that takes a community approach to prevention, treatment, and promotion of well-being.
SN - 1075-2730
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Ln., Room 17-99, Rockville, MD 20857, USA
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Ln., Room 17-99, Rockville, MD 20857, USA. kpower@samhsa.gov
U2 - PMID: 19411342.
DO - 10.1176/appi.ps.60.5.580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105532891&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105519219
T1 - The experiences of involuntarily childless Turkish immigrants in the Netherlands.
AU - van Rooij FB
AU - van Balen F
AU - Hermanns JMA
Y1 - 2009/05//
N1 - Accession Number: 105519219. Language: English. Entry Date: 20090703. Revision Date: 20150820. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 9202144.
KW - Adaptation, Psychological
KW - Immigrants -- Netherlands
KW - Infertility -- Psychosocial Factors
KW - Interpersonal Relations
KW - Minority Groups
KW - Spouses -- Psychosocial Factors
KW - Stigma
KW - Adult
KW - Exploratory Research
KW - Female
KW - Interviews
KW - Male
KW - Netherlands
KW - Phenomenological Research
KW - Qualitative Studies
KW - Thematic Analysis
KW - Turkey
KW - Human
SP - 621
EP - 632
JO - Qualitative Health Research
JF - Qualitative Health Research
JA - QUAL HEALTH RES
VL - 19
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1049-7323
AD - Public Health Service of Amsterdam, Amsterdam, the Netherlands.
U2 - PMID: 19270194.
DO - 10.1177/1049732309333242
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105519219&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bliwise, Donald L.
AU - Foley, Daniel J.
AU - Vitiello, Michael V.
AU - Ansari, Farzaneh Pour
AU - Ancoli-Israel, Sonia
AU - Walsh, James K.
T1 - Nocturia and disturbed sleep in the elderly
JO - Sleep Medicine
JF - Sleep Medicine
Y1 - 2009/05//
VL - 10
IS - 5
M3 - Article
SP - 540
EP - 548
SN - 13899457
AB - Abstract: Background: Nocturnal urination (nocturia) is such a commonplace occurrence in the lives of many older adults that it is frequently overlooked as a potential cause of sleep disturbance. Methods: We examined the prevalence of nocturia and examined its role in self-reported insomnia and poor sleep quality in a survey of 1424 elderly individuals, ages 55–84. Data were derived from a 2003 National Sleep Foundation telephone poll conducted in a representative sample of the United States population who underwent a 20-min structured telephone interview. Nocturia was not a focus of the survey, but data collected relevant to this topic allowed examination of relevant associations with sleep. Results: When inquired about in a checklist format, nocturia was listed as a self-perceived cause of nocturnal sleep “every night or almost every night” by 53% of the sample, which was over four times as frequently as the next most often cited cause of poor sleep, pain (12%). In multivariate logistic models, nocturia was an independent predictor both of self-reported insomnia (75% increased risk) and reduced sleep quality (71% increased risk), along with female gender and other medical and psychiatric conditions. Conclusions: Nocturia is a frequently overlooked cause of poor sleep in the elderly and may warrant targeted interventions. [Copyright &y& Elsevier]
AB - Copyright of Sleep Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SLEEP disorders
KW - NERVOUS system -- Diseases
KW - PATHOLOGICAL psychology
KW - UNITED States
KW - Aging
KW - Falls
KW - Health survey
KW - Nocturia
KW - Prostatism
KW - Sleep initiation and maintenance disorders
N1 - Accession Number: 39355412; Bliwise, Donald L. 1; Email Address: dbliwis@emory.edu Foley, Daniel J. 2 Vitiello, Michael V. 3 Ansari, Farzaneh Pour 1 Ancoli-Israel, Sonia 4 Walsh, James K. 5; Affiliation: 1: Program in Sleep, Aging and Chronobiology, Emory University School of Medicine, Wesley Woods Center, 1841 Clifton Road, Room 509, Atlanta, GA 30329, USA 2: Substance Abuse and Mental Health Services Administration, Rockville, MD, USA 3: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA 4: Department of Psychiatry, University of California, San Diego, CA, USA 5: Sleep Medicine and Research Center, St. Lukes’s Hospital, St. Louis, MO, USA; Source Info: May2009, Vol. 10 Issue 5, p540; Subject Term: SLEEP disorders; Subject Term: NERVOUS system -- Diseases; Subject Term: PATHOLOGICAL psychology; Subject Term: UNITED States; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Falls; Author-Supplied Keyword: Health survey; Author-Supplied Keyword: Nocturia; Author-Supplied Keyword: Prostatism; Author-Supplied Keyword: Sleep initiation and maintenance disorders; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.sleep.2008.04.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Walker, Valerie G.
AU - Li, Zheng
AU - Hulderman, Tracy
AU - Schwegler-Berry, Diane
AU - Kashon, Michael L.
AU - Simeonova, Petia P.
T1 - Potential in vitro effects of carbon nanotubes on human aortic endothelial cells
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/05//
VL - 236
IS - 3
M3 - Article
SP - 319
EP - 328
SN - 0041008X
AB - Abstract: Respiratory exposure of mice to carbon nanotubes induces pulmonary toxicity and adverse cardiovascular effects associated with atherosclerosis. We hypothesize that the direct contact of carbon nanotubes with endothelial cells will result in dose-dependent effects related to altered cell function and cytotoxicity which may play a role in potential adverse pulmonary and cardiovascular outcomes. To test this hypothesis, we examined the effects of purified single- and multi-walled carbon nanotubes (SWCNT and MWCNT) on human aortic endothelial cells by evaluating actin filament integrity and VE-cadherin distribution by fluorescence microscopy, membrane permeability by measuring the lactate dehydrogenase (LDH) release, proliferation/viability by WST-1 assay, and overall functionality by tubule formation assay. Marked actin filament and VE-cadherin disruption, cytotoxicity, and reduced tubule formation occurred consistently at 24 h post-exposure to the highest concentrations [50–150 μg/106 cells (1.5–4.5 μg/ml)] for both SWCNT and MWCNT tested in our studies. These effects were not observed with carbon black exposure and carbon nanotube exposure in lower concentrations [1–10 μg/106 cells (0.04–0.4 μg/ml)] or in any tested concentrations at 3 h post-exposure. Overall, the results indicate that SWCNT and MWCNT exposure induce direct effects on endothelial cells in a dose-dependent manner. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON -- Physiological effect
KW - ENDOTHELIUM
KW - CARBON nanotubes
KW - PULMONARY toxicology
KW - CARDIOVASCULAR diseases
KW - TOXIC substance exposure
KW - CELL proliferation
KW - FLUORESCENCE microscopy
KW - MICE as laboratory animals
KW - TOXICITY testing -- In vivo
KW - Actin
KW - Cytotoxicity
KW - MWCNT
KW - SWCNT
KW - Tubule formation
N1 - Accession Number: 37570947; Walker, Valerie G. 1 Li, Zheng 1 Hulderman, Tracy 1 Schwegler-Berry, Diane 2 Kashon, Michael L. 3 Simeonova, Petia P. 1; Email Address: psimeonova@cdc.gov; Affiliation: 1: Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA 2: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA 3: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: May2009, Vol. 236 Issue 3, p319; Subject Term: CARBON -- Physiological effect; Subject Term: ENDOTHELIUM; Subject Term: CARBON nanotubes; Subject Term: PULMONARY toxicology; Subject Term: CARDIOVASCULAR diseases; Subject Term: TOXIC substance exposure; Subject Term: CELL proliferation; Subject Term: FLUORESCENCE microscopy; Subject Term: MICE as laboratory animals; Subject Term: TOXICITY testing -- In vivo; Author-Supplied Keyword: Actin; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: MWCNT; Author-Supplied Keyword: SWCNT; Author-Supplied Keyword: Tubule formation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2009.02.018
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choudhuri, Supratim
T1 - Looking back to the future: From the development of the gene concept to toxicogenomics.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2009/05//
VL - 19
IS - 4
M3 - Article
SP - 263
EP - 277
PB - Taylor & Francis Ltd
SN - 15376516
AB - Initial progress in the science of ‘genetics’ in the first half of the 20th century was mainly driven by studies utilizing mutations and consequent changes in phenotype. The structural and functional nature of the gene was far from being understood. That state of understanding started changing from the 1940s. In the following decades, with the discovery of the double helix followed by the discoveries on gene structure and expression, there was a period when the structural and functional aspects of the gene could be conceived in terms of one entity, the cistron. However, the discovery of intervening sequences caused this unified concept to fall apart, making the gene concept a subject of philosophical debate again. Meanwhile, over time, technological progress in molecular biology had the field forge ahead rapidly, ultimately leading to the sequencing of the human genome and genomes of other species, and giving birth to the science of genomics. Developments in genomics have given rise to certain applied sub-disciplines like pharmacogenomics and toxicogenomics. While the full potential of pharmaco- and toxicogenomics is yet to be harnessed, they nevertheless have had an impact in drug development and safety assessment, such that the future promise of genomics seems achievable. At present, it is a good opportunity to revisit the path from the development of the initial gene concept and the philosophical debate surrounding the meaning of the term ‘gene’ to the current state of understanding of genes and genomes and their role in health and disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOGENOMICS
KW - GENES
KW - GENOMES
KW - GENOMICS
KW - PHARMACOGENOMICS
KW - MOLECULAR biology
KW - cistron
KW - Gene
KW - gene concept
KW - genome
KW - microarray
KW - pharmacogenomics
KW - sequencing
KW - toxicogenomics
N1 - Accession Number: 43539358; Choudhuri, Supratim 1; Email Address: supratim.choudhuri@fda.hhs.gov; Affiliation: 1: US Food and Drug Administration, Division of Biotechnology and GRAS Notice Review, Center for Food Safety and Applied Nutrition, MD, USA.; Source Info: May2009, Vol. 19 Issue 4, p263; Subject Term: TOXICOGENOMICS; Subject Term: GENES; Subject Term: GENOMES; Subject Term: GENOMICS; Subject Term: PHARMACOGENOMICS; Subject Term: MOLECULAR biology; Author-Supplied Keyword: cistron; Author-Supplied Keyword: Gene; Author-Supplied Keyword: gene concept; Author-Supplied Keyword: genome; Author-Supplied Keyword: microarray; Author-Supplied Keyword: pharmacogenomics; Author-Supplied Keyword: sequencing; Author-Supplied Keyword: toxicogenomics; Number of Pages: 15p; Document Type: Article
L3 - 10.1080/15376510902855529
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-06563-002
AN - 2009-06563-002
AU - Snowden, Lonnie R.
AU - Masland, Mary C.
AU - Wallace, Neal
AU - Fawley, Kya
T1 - Associating supplemental case management activities with ethnic minority children’s reduced use of psychiatric emergency services.
JF - Psychological Services
JO - Psychological Services
JA - Psychol Serv
Y1 - 2009/05//
VL - 6
IS - 2
SP - 117
EP - 125
CY - US
PB - Educational Publishing Foundation
SN - 1541-1559
SN - 1939-148X
AD - Snowden, Lonnie R., University of California, 235 University Hall, Berkeley, CA, US, 94729-7360
N1 - Accession Number: 2009-06563-002. Partial author list: First Author & Affiliation: Snowden, Lonnie R.; Center for Mental Health Services Research, University of California, Berkeley, CA, US. Release Date: 20090511. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Case Management; Crises; Emergency Services; Mental Health Services; Minority Groups. Minor Descriptor: Health Care Utilization. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2009. Publication History: Accepted Date: Dec 12, 2008; Revised Date: Nov 10, 2008; First Submitted Date: Mar 12, 2008. Copyright Statement: American Psychological Association. 2009.
AB - Studying children and adolescents receiving publicly financed outpatient treatment, the authors investigated whether receipt of supplemental case management was associated with reduced odds of ethnic minority children’s and adolescent’s receipt of crisis care, and whether the minority’s reduction was greater than the reduction for Whites. The data were 97,618 Medicaid records of mental health services provided to children and adolescents ages 0–18 years in California’s public mental health system. The study’s quasi-experimental research capitalized on a large, multisystem, and multiyear data set to address key challenges to internal and external validity. Results indicated that receiving case management along with outpatient treatment was associated with significantly reduced odds of crisis service use for Blacks, Asian Americans, and Latinos especially. The results provide preliminary evidence that supplementing outpatient care with case management helps to close a troubling disparity in mental health treatment access. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - race
KW - crisis
KW - emergency
KW - psychiatry
KW - children
KW - supplemental case management services
KW - mental health services
KW - crisis service use
KW - minority groups
KW - 2009
KW - Case Management
KW - Crises
KW - Emergency Services
KW - Mental Health Services
KW - Minority Groups
KW - Health Care Utilization
KW - 2009
DO - 10.1037/a0015346
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06563-002&site=ehost-live&scope=site
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06404-002
AN - 2009-06404-002
AU - Ferguson, Sherry A.
AU - Delclos, K. Barry
AU - Newbold, Retha R.
AU - Flynn, Katherine M.
T1 - Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague-Sawley rats.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2009/05//May-Jun, 2009
VL - 31
IS - 3
SP - 143
EP - 148
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Ferguson, Sherry A., Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079
N1 - Accession Number: 2009-06404-002. PMID: 19452615 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Ferguson, Sherry A.; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, US. Release Date: 20091012. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Flynn, Katherine M. Major Descriptor: Animal Sex Differences; Diets; Pharmacology; Sodium. Minor Descriptor: Rats. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30); Female (40). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Other Internet. References Available: Y. Page Count: 6. Issue Publication Date: May-Jun, 2009. Publication History: First Posted Date: Jan 21, 2009; Accepted Date: Jan 7, 2009; Revised Date: Dec 22, 2008; First Submitted Date: Oct 6, 2008.
AB - Previous work in our laboratory indicated that lifelong dietary exposure to estrogen-like endocrine disrupters increased sodium solution intake in adult male and female rats. Here, we sought to discern the critical periods necessary for this alteration as well as establish the effects of lower dietary concentrations of genistein and nonylphenol. Male and female Sprague–Dawley rats (F0) consumed phytoestrogen-free chow containing 0, 5, 100, or 500 ppm genistein (≈ 0.0, 0.4, 8.0, and 40.0 mg/kg/day) or 0, 25, 200, or 750 ppm nonylphenol (≈ 0.0, 2.0, 16.0, and 60.0 mg/kg/day). Rats were mated within treatment groups and offspring (F1) maintained on the same diets. Mating for the F1, F2, and F3 (genistein only) was within treatment groups. At postnatal day (PND) 21, the F3 generation began to consume unadulterated phytoestrogen-free chow such that genistein exposure occurred only in utero and preweaning. The F4 generation was never directly exposed to genistein. On PNDs 65–68, intake of regular water and a 3.0% sodium chloride solution was measured for F1–F4 generations (genistein portion) or F1–F2 (nonylphenol portion). Although body weights were decreased by the highest dietary concentrations of genistein and nonylphenol, there were only minimal effects of exposure on sodium solution intake. As expected, intake was highest in female rats. With previous data, these results indicate that the dietary concentrations necessary to increase adult sodium solution intake in rats are greater than 500 ppm genistein and 750 ppm nonylphenol and such effects do not appear to increase across generations. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - dietary concentrations
KW - genistein
KW - nonylphenol
KW - sodium solution intake
KW - rats
KW - pharmacology
KW - sex differences
KW - 2009
KW - Animal Sex Differences
KW - Diets
KW - Pharmacology
KW - Sodium
KW - Rats
KW - 2009
U1 - Sponsor: US Food and Drug Administration/National Institute for Environmental Health Sciences, US. Grant: IAG 224-07- 007. Recipients: No recipient indicated
U1 - Sponsor: Oak Ridge Institute for Science Education. Other Details: post-doctoral fellowship. Recipients: Flynn, Katherine M.
DO - 10.1016/j.ntt.2009.01.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06404-002&site=ehost-live&scope=site
UR - Sherry.Ferguson@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06699-002
AN - 2009-06699-002
AU - Norris, Fran H.
AU - Bellamy, Nikki D.
T1 - Evaluation of a national effort to reach Hurricane Katrina survivors and evacuees: The Crisis Counseling Assistance and Training Program.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2009/05//
VL - 36
IS - 3
SP - 165
EP - 175
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Norris, Fran H., National Center for Posttraumatic Stress Disorder (NCPTSD), VAMC, (116D), 215 North Main Street, White River Junction,, VT, US, 05009
N1 - Accession Number: 2009-06699-002. PMID: 19365722 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Norris, Fran H.; Dartmouth Medical School, Hanover, NH, US. Release Date: 20090803. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Counselors; Mental Health Program Evaluation; Mental Health Services; Natural Disasters. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: May, 2009.
AB - Hurricane Katrina created the largest population of internally displaced persons in the history of the United States. Exceptions to Federal Emergency Management Agency’s (FEMA’s) usual eligibility requirements allowed states from across the nation to apply for Crisis Counseling Assistance and Training Program (CCP) grants to provide services to evacuees. Over a 16-month period, crisis counselors documented 1.2 million individual and group encounters across 19 CCPs. Most encounters (936,000, 80%) occurred in Presidential disaster-declared areas of Louisiana, Mississippi, and Alabama, but many (237,000, 20%) occurred in 16 smaller 'undeclared' programs across the country. Programs showed excellent reach relative to external benchmarks provided by FEMA registrations for individual assistance and population characteristics. Programs varied widely in service mix and intensity. The declared programs reached more people, but the undeclared programs provided more intensive services to fewer people with higher needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Hurricane Katrina
KW - Crisis Counseling Assistance and Training Program
KW - program evaluation
KW - counselors
KW - 2009
KW - Counseling
KW - Counselors
KW - Mental Health Program Evaluation
KW - Mental Health Services
KW - Natural Disasters
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Mental Health Services (CMHS). Grant: AM06C5600A. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder (NCPTSD), Executive Division, US. Recipients: No recipient indicated
U1 - Sponsor: Department of Homeland Security, Center of Excellence in the Social and Behavioral Sciences. Grant: N00140510629. Other Details: National Consortium for the Study of Terrorism and Responses to Terrorism (START). Recipients: No recipient indicated
DO - 10.1007/s10488-009-0217-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06699-002&site=ehost-live&scope=site
UR - fran.norris@dartmouth.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06699-004
AN - 2009-06699-004
AU - Rosen, Craig S.
AU - Matthieu, Monica M.
AU - Norris, Fran H.
T1 - Factors predicting crisis counselor referrals to other crisis counseling, disaster relief, and psychological services: A cross-site analysis of post-Katrina programs.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2009/05//
VL - 36
IS - 3
SP - 186
EP - 194
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - Norris, Fran H., National Center for Posttraumatic Stress Disorder, 215 North Main Street, White River Junction, VT, US, 05009
N1 - Accession Number: 2009-06699-004. PMID: 19381795 Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: Rosen, Craig S.; National Center for Posttraumatic Stress Disorder, Stanford University School of Medicine, Palo Alto, CA, US. Release Date: 20090803. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Counseling; Counselors; Mental Health Services; Natural Disasters; Professional Referral. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Short Post-Traumatic Stress Disorder Rating Interview DOI: 10.1037/t05181-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2009.
AB - An important aspect of crisis counseling is linking survivors with services for their unmet needs. We examined determinants of referrals for disaster relief, additional crisis counseling, and psychological services in 703,000 crisis counseling encounters 3–18 months after Hurricane Katrina. Referrals for disaster relief were predicted by clients’ losses, age (adults rather than children), and urbanicity. Referrals for additional counseling and psychological services were predicted by urbanicity, losses and trauma exposure, prior trauma, and preexisting mental health problems. Counseling and psychological referrals declined over time despite continuing mental health needs. Results confirm large urban–rural disparities in access to services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - crisis counselor referrals
KW - crisis counseling
KW - disaster relief
KW - psychological services
KW - Hurricane Katrina
KW - post Katrina programs
KW - 2009
KW - Counseling
KW - Counselors
KW - Mental Health Services
KW - Natural Disasters
KW - Professional Referral
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Other Details: Interagency agreement. Recipients: No recipient indicated
U1 - Sponsor: US Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder (NCPTSD), Executive Division, US. Recipients: No recipient indicated
U1 - Sponsor: Department of Homeland Security, Center of Excellence in the Social and Behavioral Sciences. Grant: N00140510629. Other Details: National Consortium for the Study of Terrorism and Responses to Terrorism (START). Recipients: No recipient indicated
DO - 10.1007/s10488-009-0216-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06699-004&site=ehost-live&scope=site
UR - fran.norris@dartmouth.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06124-008
AN - 2009-06124-008
AU - Takahashi, Masaya
AU - Iwakiri, Kazuyuki
AU - Sotoyama, Midori
AU - Hirata, Mamoru
AU - Hisanaga, Naomi
T1 - Musculoskeletal pain and night-shift naps in nursing home care workers.
JF - Occupational Medicine
JO - Occupational Medicine
JA - Occup Med (Lond)
Y1 - 2009/05//
VL - 59
IS - 3
SP - 197
EP - 200
CY - United Kingdom
PB - Oxford University Press
SN - 0962-7480
SN - 1471-8405
AD - Takahashi, Masaya, National Institute of Occupational Safety and Health, 6-21-1, Nagao, Tama-ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2009-06124-008. PMID: 19286994 Partial author list: First Author & Affiliation: Takahashi, Masaya; National Institute of Occupational Safety and Health, Kawasaki, Japan. Release Date: 20100111. Correction Date: 20160616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Musculoskeletal Disorders; Napping; Nursing Homes; Workday Shifts; Health Personnel. Classification: Professional Personnel Attitudes & Characteristics (3430); Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Epworth Sleepiness Scale DOI: 10.1037/t07081-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 4. Issue Publication Date: May, 2009. Publication History: First Posted Date: Mar 13, 2009. Copyright Statement: All rights reserved. The Author. 2009.
AB - Background: Care workers in nursing homes are at high risk of developing musculoskeletal disorders (MSDs). Many care workers work in shifts, which may compromise both the quality of care they give and their working life. Taking a nap during night shifts has been proposed to ameliorate shift work-related problems, but its relationship with MSDs is not clear. Aims: To explore how MSD pain differs according to frequency of night-shift naps. Methods: A questionnaire study was conducted on 111 care workers at three nursing homes. Of 98 respondents, data from 66 shift workers (54 women) were analyzed. Data on self-rated pain in multiple sites (neck, shoulder, arm, leg and low back), naps during night shifts and relevant variables were collected. Participants were categorized into three groups on the basis of frequency of night-shift naps taken during the previous month: non-nappers, <50% nappers and ≥50% nappers. Results: Pain at all sites, with the exception of low back pain, differed significantly among the three groups. Pain scores were lowest at the arm and leg for the ≥50% nappers. Neck and shoulder pain was lower for the ≥50% nappers and the non-nappers compared to the <50% nappers. Conclusions: Reduced pain in the arm and leg was associated with taking a nap at least once every two night shifts among the nursing home care workers. No association was found between low back pain and nightshift naps in this sample. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - musculoskeletal pains
KW - night-shift naps
KW - nursing home care workers
KW - musculoskeletal disorders
KW - 2009
KW - Musculoskeletal Disorders
KW - Napping
KW - Nursing Homes
KW - Workday Shifts
KW - Health Personnel
KW - 2009
U1 - Sponsor: National Institute of Occupational Safety and Health, Japan. Grant: P16-02; P20-05. Recipients: No recipient indicated
DO - 10.1093/occmed/kqp029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06124-008&site=ehost-live&scope=site
UR - takaham@h.jniosh.go.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-03567-006
AN - 2009-03567-006
AU - Pérez-De La Cruza, Verónica
AU - Elinos-Calderóna, Diana
AU - Robledo-Arratia, Yolanda
AU - Medina-Campos, Omar N.
AU - Pedraza-Chaverrí, José
AU - Ali, Syed F.
AU - Santamaría, Abel
T1 - Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington’s disease.
JF - Behavioural Brain Research
JO - Behavioural Brain Research
JA - Behav Brain Res
Y1 - 2009/05//
VL - 199
IS - 2
SP - 210
EP - 217
CY - Netherlands
PB - Elsevier Science
SN - 0166-4328
AD - Santamaría, Abel, Laboratorio de Aminoacidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, S.S.A., Insurgentes Sur 3877, Mexico, Mexico, D.F. 14269
N1 - Accession Number: 2009-03567-006. Partial author list: First Author & Affiliation: Pérez-De La Cruza, Verónica; Laboratorio de Aminoacidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, S.S.A., Mexico, Mexico. Release Date: 20090601. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Ali, Syed F. Major Descriptor: Acids; Animal Locomotion; Animal Models; Huntingtons Disease; Lipid Metabolism. Minor Descriptor: Lipids; Rats; Stress; Synapses; Mitochondria. Classification: Psychopharmacology (2580); Physical & Somatoform & Psychogenic Disorders (3290). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 2009. Publication History: First Posted Date: Nov 30, 2008; Accepted Date: Nov 25, 2008; Revised Date: Nov 19, 2008; First Submitted Date: Oct 23, 2008. Copyright Statement: All rights reserved. Elsevier B.V. 2008.
AB - In this study, we reproduced two toxic models resembling some motor/kinetic deficits of Huntington's disease induced by bilateral intrastriatal injections of either quinolinic acid (QUIN, 120 nmol/μl per side) or 3-nitropropionic acid (3-NP, 250 nmol/μl per side) to rats. Motor skills (including total distance walked/traveled and total horizontal and vertical activities) were evaluated in a box-field system at 1 and 7 days post-lesion. In order to investigate whether these alterations were associated with the oxidative/nitrergic stress evoked by the nitrogen reactive species peroxynitrite (ONOO−) in the striatum, some rats were pretreated with the ONOO− decomposition catalyst iron porphyrinate (Fe(TPPS), 10 mg/kg, i.p.) 120 min prior to toxins infusion. With the aim to further characterize some possible mechanisms by which motor tasks were affected and/or preserved, biochemical analysis of peroxidative damage to lipids and mitochondrial dysfunction were both assessed in synaptic membranes isolated from the striata of QUIN-, 3-NP- and/or Fe(TPPS)-treated animals. Our results show that targeting oxidative/nitrergic stress by Fe(TPPS) in these toxic models results in amelioration of motor deficits linked to inhibition of peroxidative damage and recovery of mitochondrial function in synaptic membranes. Based on these findings, we hypothesize that the protection exerted by Fe(TPPS) on the biochemical markers analyzed reflects the possible preservation of the functional status of the nerve tissue by limiting the deleterious actions of ONOO−, further accounting for partial recovery of integrative motor functions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - oxidative/nitrergic stress
KW - motor impairment
KW - synaptic mitochondrial dysfunction
KW - lipid peroxidation
KW - Huntingtons disease
KW - quinolinic acid
KW - 3-nitropropionic acid
KW - rats
KW - 2009
KW - Acids
KW - Animal Locomotion
KW - Animal Models
KW - Huntingtons Disease
KW - Lipid Metabolism
KW - Lipids
KW - Rats
KW - Stress
KW - Synapses
KW - Mitochondria
KW - 2009
U1 - Sponsor: CONACyT-México. Grant: 48370-Q. Recipients: Ali, Syed F.
U1 - Sponsor: DGAPA PAPIIT. Grant: IN 207007. Recipients: Pedraza-Chaverrí, José
DO - 10.1016/j.bbr.2008.11.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-03567-006&site=ehost-live&scope=site
UR - absada@yahoo.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06862-004
AN - 2009-06862-004
AU - Furia, Andrea C.
AU - Lee, Rebecca E.
AU - Strother, Myra L.
AU - Huang, Terry T.-K.
T1 - College students' motivation to achieve and maintain a healthy weight.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2009/05//May-Jun, 2009
VL - 33
IS - 3
SP - 256
EP - 263
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Huang, Terry T.-K., Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, 4B11, Bethesda, MD, US, 20892-7510
N1 - Accession Number: 2009-06862-004. PMID: 19063647 Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Furia, Andrea C.; Office of Special Health Issues, Food and Drug Administration, Rockville, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Body Weight; College Students; Human Sex Differences; Motivation; Weight Control. Classification: Personality Traits & Processes (3120). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May-Jun, 2009.
AB - Objectives: To develop and refine a scale of motivational factors related to healthy weight achievement and maintenance and to examine differences by gender and weight status. Methods: A cross-sectional survey of 300 university students aged 18-24 years. Results: Factor analysis yielded 6 factors—Intrinsic (Cronbach’s α = 0.73): affective motivation, self-efficacy/interest; Extrinsic (Cronbach’s α = 0.68): social reward, peer pressure, lack of choice, and authority influence. Males and normal-weight students showed higher affective motivation and overall intrinsic motivation compared to females and overweight students, (P < .001). Conclusion: Intrinsic motivational factors and gender differences should be considered in developing obesity prevention interventions in this age-group. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - college students' motivation
KW - healthy weight achievement
KW - healthy weight maintenance
KW - gender differences
KW - weight status
KW - 2009
KW - Body Weight
KW - College Students
KW - Human Sex Differences
KW - Motivation
KW - Weight Control
KW - 2009
DO - 10.5993/AJHB.33.3.4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06862-004&site=ehost-live&scope=site
UR - huangter@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07211-010
AN - 2009-07211-010
AU - Carrillo, Maria C.
AU - Sanders, Charles A.
AU - Katz, Russell G.
T1 - Maximizing the Alzheimer's Disease Neuroimaging Initiative II.
JF - Alzheimer's & Dementia: The Journal of the Alzheimer's Association
JO - Alzheimer's & Dementia: The Journal of the Alzheimer's Association
JA - Alzheimers Dement
Y1 - 2009/05//
VL - 5
IS - 3
SP - 271
EP - 275
CY - Netherlands
PB - Elsevier Science
SN - 1552-5260
SN - 1552-5279
AD - Carrillo, Maria C.
N1 - Accession Number: 2009-07211-010. PMID: 19362888 Partial author list: First Author & Affiliation: Carrillo, Maria C.; Alzheimer’s Association, Chicago, IL, US. Release Date: 20090727. Correction Date: 20150216. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Alzheimer's Disease; Brain; Cognitive Impairment; Neuroimaging. Minor Descriptor: Cognitive Ability. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Tests & Measures: Alzheimers Disease Assessment Scale-Cognitive Subscale; Mini Mental State Examination. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: May, 2009.
AB - The Alzheimer’s Disease Neuroimaging Initiative is the largest public-private partnership on brain research underway at the National Institutes of Health. This 6-year study tracks cognitive and brain changes in normal subjects, those with mild cognitive impairment, and individuals with Alzheimer’s disease. It was designed to provide better tools for performing effective clinical trials, and is slated to run until 2010. While data are being generated and analyzed, researchers involved in the study are developing an extension, i.e., the Alzheimer’s Disease Neuroimaging Initiative II. The Foundation for the National Institutes of Health and the Alzheimer’s Association convened a meeting to review the progress, evaluate future directions, and obtain the United States Food and Drug Administration’s perspective on how the Alzheimer’s Disease Neuroimaging Initiative could affect the drug-approval process. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Alzheimers Disease Neuroimaging Initiative II
KW - brain research
KW - mild cognitive impairment
KW - 2009
KW - Alzheimer's Disease
KW - Brain
KW - Cognitive Impairment
KW - Neuroimaging
KW - Cognitive Ability
KW - 2009
U1 - Sponsor: National Institute on Aging, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Institute for Biomedical Imaging and Bioengineering, US. Recipients: No recipient indicated
U1 - Sponsor: Food and Drug Administration. Recipients: No recipient indicated
DO - 10.1016/j.jalz.2009.02.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07211-010&site=ehost-live&scope=site
UR - Maria.Carrillo@alz.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06862-007
AN - 2009-06862-007
AU - Gust, Deborah A.
AU - Kennedy, Allison
AU - Weber, Deanne
AU - Evans, Geoff
AU - Kong, Yuan
AU - Salmon, Daniel
T1 - Parents questioning immunization: Evaluation of an intervention.
JF - American Journal of Health Behavior
JO - American Journal of Health Behavior
JA - Am J Health Behav
Y1 - 2009/05//May-Jun, 2009
VL - 33
IS - 3
SP - 287
EP - 298
CY - US
PB - American Journal of Health Behavior
SN - 1087-3244
SN - 1945-7359
AD - Gust, Deborah A., Immunization Service Division, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA, US, 30333
N1 - Accession Number: 2009-06862-007. PMID: 19063650 Other Journal Title: Health Values: Health Behavior, Education & Promotion; Health Values: The Journal of Health Behavior, Education & Promotion. Partial author list: First Author & Affiliation: Gust, Deborah A.; Immunization Service Division, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Gust, Deborah A. Major Descriptor: Health Education; Immunization; Parental Attitudes. Minor Descriptor: Laws. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: May-Jun, 2009.
AB - Objectives: To compare attitudes of parents who filed or considered filing an exemption to school immunization requirements and/or would not have their child immunized if it were not required by law (cases) to controls. To develop and evaluate a brochure intervention for parents considering an exemption. Methods: Interviews, focus groups, mailed surveys. Results: Cases had more negative attitudes about vaccines than controls did. Although the brochure did not significantly improve parents’ immunization attitudes compared to controls, most parents who received the intervention reported a positive impression. Conclusions: A science-based educational intervention for parents considering a vaccine exemption may help improve parents’ opinions of childhood vaccines. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parents' attitudes
KW - immunization
KW - law
KW - exemption
KW - 2009
KW - Health Education
KW - Immunization
KW - Parental Attitudes
KW - Laws
KW - 2009
U1 - Sponsor: National Vaccine Program Office. Recipients: Gust, Deborah A.; Kennedy, Allison; Weber, Deanne; Evans, Geoff; Kong, Yuan; Salmon, Daniel
DO - 10.5993/AJHB.33.3.7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06862-007&site=ehost-live&scope=site
UR - dgust@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-02662-008
AN - 2009-02662-008
AU - Simeonov, Peter
AU - Hsiao, Hongwei
AU - Hendricks, Scott
T1 - Effectiveness of vertical visual reference for reducing postural instability on inclined and compliant surfaces at elevation.
JF - Applied Ergonomics
JO - Applied Ergonomics
JA - Appl Ergon
Y1 - 2009/05//
VL - 40
IS - 3
SP - 353
EP - 361
CY - Netherlands
PB - Elsevier Science
SN - 0003-6870
AD - Simeonov, Peter, Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2009-02662-008. PMID: 19100527 Partial author list: First Author & Affiliation: Simeonov, Peter; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20090824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cues; Equilibrium; Linear Perspective; Posture. Minor Descriptor: Accident Prevention; Falls; Skilled Industrial Workers. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2009.
AB - Falls from elevation continue to be the most serious hazard for the workers in construction. Simple and cost effective technical approaches to improve workers’ balance on sloped roofs and deformable/unstable platforms have potential to reduce the risk of falls. This study evaluated the effectiveness of simple vertical structures as visual references (cue) for balance improvement. Twenty-four construction workers were tested while standing on sloped and deformable surfaces at elevation and performing undemanding visual tasks with vertical structures positioned at different proximal locations. Workers’ balance performance was assessed by sway parameters calculated from the center-of-pressure movement collected with a force platform. The study results indicate increased instability on the sloped and deformable surfaces at elevation, and show that a simple vertical structure, e.g., a narrow bar, can serve as a visual cue and assist workers’ balance. Workers’ balance improved linearly with cue proximity in the tested distance range both on the sloped and the deformable surfaces. At a moment of instability, workers can redirect their attention to a proximal structure, available in the line of sight, to assist balance control. These findings may be useful in modifying elevated work environments and construction procedures to improve workers’ postural balance during various construction phases. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - vertical visual reference
KW - postural instability
KW - inclined surfaces
KW - compliant surfaces
KW - elevation
KW - cue
KW - balance improvement
KW - 2009
KW - Cues
KW - Equilibrium
KW - Linear Perspective
KW - Posture
KW - Accident Prevention
KW - Falls
KW - Skilled Industrial Workers
KW - 2009
DO - 10.1016/j.apergo.2008.11.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-02662-008&site=ehost-live&scope=site
UR - psimeonov@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-05189-002
AN - 2009-05189-002
AU - Clegg, Limin X.
AU - Reichman, Marsha E.
AU - Miller, Barry A.
AU - Hankey, Benjamin F.
AU - Singh, Gopal K.
AU - Lin, Yi Dan
AU - Goodman, Marc T.
AU - Lynch, Charles F.
AU - Schwartz, Stephen M.
AU - Chen, Vivien W.
AU - Bernstein, Leslie
AU - Gomez, Scarlett L.
AU - Graff, John J.
AU - Lin, Charles C.
AU - Johnson, Norman J.
AU - Edwards, Brenda K.
T1 - Impact of socioeconomic status on cancer incidence and stage at diagnosis: Selected findings from the surveillance, epidemiology, and end results: National Longitudinal Mortality Study.
JF - Cancer Causes & Control
JO - Cancer Causes & Control
JA - Cancer Causes Control
Y1 - 2009/05//
VL - 20
IS - 4
SP - 417
EP - 435
CY - Germany
PB - Springer
SN - 0957-5243
SN - 1573-7225
AD - Clegg, Limin X., Office of Healthcare Inspections, Office of Inspector General (54AA), U.S. Department of Veterans Affairs, 810 Vermont Ave., NW, Washington, DC, US, 20420
N1 - Accession Number: 2009-05189-002. PMID: 19002764 Partial author list: First Author & Affiliation: Clegg, Limin X.; Office of Healthcare Inspections, Office of Inspector General (54AA), U.S. Department of Veterans Affairs, Washington, DC, US. Release Date: 20091109. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diagnosis; Epidemiology; Neoplasms; Socioeconomic Status; Health Disparities. Minor Descriptor: Disease Course. Classification: Cancer (3293). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 19. Issue Publication Date: May, 2009. Publication History: First Posted Date: Nov 12, 2008; Accepted Date: Oct 21, 2008; First Submitted Date: Jun 6, 2008. Copyright Statement: This article is published with open access at Springerlink.com. The Author(s). 2008.
AB - Background Population-based cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program at the National Cancer Institute (NCI) are mainly based on medical records and administrative information. Individual-level socioeconomic data are not routinely reported by cancer registries in the United States because they are not available in patient hospital records. The U.S. representative National Longitudinal Mortality Study (NLMS) data provide self-reported, detailed demographic and socioeconomic data from the Social and Economic Supplement to the Census Bureau's Current Population Survey (CPS). In 1999, the NCI initiated the SEER-NLMS study, linking the population-based SEER cancer registry data to NLMS data. The SEER-NLMS data provide a new unique research resource that is valuable for health disparity research on cancer burden. We describe the design, methods, and limitations of this data set. We also present findings on cancer-related health disparities according to individual-level socioeconomic status (SES) and demographic characteristics for all cancers combined and for cancers of the lung, breast, prostate, cervix, and melanoma. Methods Records of cancer patients diagnosed in 1973–2001 when residing 1 of 11 SEER registries were linked with 26 NLMS cohorts. The total number of SEER matched cancer patients that were also members of an NLMS cohort was 26,844. Of these 26,844 matched patients, 11,464 were included in the incidence analyses and 15,357 in the late-stage diagnosis analyses. Matched patients (used in the incidence analyses) and unmatched patients were compared by age group, sex, race, ethnicity, residence area, year of diagnosis, and cancer anatomic site. Cohort-based age-adjusted cancer incidence rates were computed. The impact of socioeconomic status on cancer incidence and stage of diagnosis was evaluated. Results Men and women with less than a high school education had elevated lung cancer rate ratios of 3.01 and 2.02, respectively, relative to their college educated counterparts. Those with family annual incomes less than $12,500 had incidence rates that were more than 1.7 times the lung cancer incidence rate of those with incomes $50,000 or higher. Lower income was also associated with a statistically significantly increased risk of distant-stage breast cancer among women and distant-stage prostate cancer among men. Conclusions Socioeconomic patterns in incidence varied for specific cancers, while such patterns for stage were generally consistent across cancers, with late-stage diagnoses being associated with lower SES. These findings illustrate the potential for analyzing disparities in cancer outcomes according to a variety of individual-level socioeconomic, demographic, and health care characteristics, as well as by area measures available in the linked database. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - socioeconomic status
KW - cancer incidence
KW - stage at diagnosis
KW - National Longitudinal Mortality Study
KW - health disparities
KW - 2009
KW - Diagnosis
KW - Epidemiology
KW - Neoplasms
KW - Socioeconomic Status
KW - Health Disparities
KW - Disease Course
KW - 2009
DO - 10.1007/s10552-008-9256-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05189-002&site=ehost-live&scope=site
UR - Lin.Clegg@va.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06920-006
AN - 2009-06920-006
AU - Schulze, T. G.
AU - Detera-Wadleigh, S. D.
AU - Akula, N.
AU - Gupta, A.
AU - Kassem, L.
AU - Steele, J.
AU - Pearl, J.
AU - Strohmaier, J.
AU - Breuer, R.
AU - Schwarz, M.
AU - Propping, P.
AU - Nöthen, M. M.
AU - Cichon, S.
AU - Schumacher, J.
AU - Rietschel, M.
AU - McMahon, F. J.
T1 - Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2009/05//
VL - 14
IS - 5
SP - 487
EP - 491
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Schulze, T. G., Unit on Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Building 35, Room 1A205, 35 Convent Drive, Bethesda, MD, US, 20892-3719
N1 - Accession Number: 2009-06920-006. PMID: 19088739 Partial author list: First Author & Affiliation: Schulze, T. G.; Unit on Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Institutional Authors: NIMH Genetics Initiative Bipolar Disorder Consortium. Release Date: 20090831. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Grant Information: Schulze, T. G. Major Descriptor: Bipolar Disorder; Genetics; Genome; Independent Variables; Risk Factors. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: May, 2009.
AB - Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD). We first reported association between BD and the ANK3 marker rs9804190 in a genome-wide association study (GWAS) of two independent samples (Baum et al., 2008). Subsequently, a meta-analysis of GWAS data based on samples from the US and the UK reported association with a different ANK3 marker, rs10994336 (Ferreira et al., 2008). The markers lie about 340 kb apart in the gene. Here, we test both markers in additional samples and characterize the contribution of each marker to BD risk. Our previously reported findings at rs9804190, which had been based on DNA pooling, were confirmed by individual genotyping in the National Institute of Mental Health (NIMH) waves 1–4 (P = 0.05; odds ratio (OR) = 1.24) and German (P = 0.0006; OR = 1.34) samples. This association was replicated in an independent US sample known as NIMH wave 5 (466 cases, 212 controls; P = 0.017; OR = 1.38). A random-effects meta-analysis of all three samples was significant (P = 3 × 10-6; OR = 1.32), with no heterogeneity. Individual genotyping of rs10994336 revealed a significant association in the German sample (P = 0.0001; OR = 1.70), and similar ORs in the NIMH 1–4 and NIMH 5 samples that were not significant at the P < 0.05 level. Meta-analysis of all three samples supported an association with rs10994336 (P = 1.7 × 10-5; OR = 1.54), again with no heterogeneity. There was little linkage disequilibrium between the two markers. Further analysis suggested that each marker contributed independently to BD, with no significant marker × marker interaction. Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genetics
KW - risk factors
KW - ankyrin
KW - independent variables
KW - bipolar disorder
KW - genome
KW - 2009
KW - Bipolar Disorder
KW - Genetics
KW - Genome
KW - Independent Variables
KW - Risk Factors
KW - 2009
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: No recipient indicated
U1 - Sponsor: Deutsche Forschungsgemeinschaft, Germany. Recipients: No recipient indicated
U1 - Sponsor: Federal Ministry of Education and Research, National German Genome Research Network, Germany. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: Schulze, T. G.; McMahon, F. J.
U1 - Sponsor: Alfried Krupp Von Bohlen Und Halbach-Stiftung. Recipients: No recipient indicated
DO - 10.1038/mp.2008.134
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06920-006&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR - ORCID: 0000-0002-9475-086X
UR -
UR - schulzet@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06603-012
AN - 2009-06603-012
AU - Iannotti, Ronald J.
AU - Kogan, Michael D.
AU - Janssen, Ian
AU - Boyce, William F.
T1 - Patterns of adolescent physical activity, screen-based media use, and positive and negative health indicators in the U.S. and Canada.
JF - Journal of Adolescent Health
JO - Journal of Adolescent Health
JA - J Adolesc Health
Y1 - 2009/05//
VL - 44
IS - 5
SP - 493
EP - 499
CY - Netherlands
PB - Elsevier Science
SN - 1054-139X
AD - Iannotti, Ronald J., 6100 Executive Blvd., 7B05, Bethesda, MD, US, 20892-7510
N1 - Accession Number: 2009-06603-012. PMID: 19380098 Other Journal Title: Journal of Adolescent Health Care. Partial author list: First Author & Affiliation: Iannotti, Ronald J.; Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Baltimore, MD, US. Release Date: 20090720. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Communications Media; Health; Health Behavior; Physical Activity. Minor Descriptor: Adolescent Psychology. Classification: Psychosocial & Personality Development (2840); Mass Media Communications (2750). Population: Human (10); Male (30); Female (40). Location: Canada; US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: May, 2009.
AB - Purpose: To examine: (1) how adolescent physical activity (PA) and screen-based media use (SBM) relate to physical and social health indicators, and (2) cross national differences in these relationships. Methods: Essentially identical questions and methodologies were used in the Health Behavior in School-Aged Children cross-sectional surveys of nationally representative samples of American (N = 14,818) and Canadian (N = 7266) students in grades 6 to 10. Items included questions about frequency of PA, SBM, positive health indicators (health status, self-image, quality of life, and quality of family and peer relationships), and negative health indicators (health complaints, physical aggression, smoking, drinking, and marijuana use). Results: In regression analyses controlling for age and gender, positive health indicators were uniformly positively related to PA while two negative health indicators were negatively related to PA. However, PA was positively related to physical aggression. The pattern for SBM was generally the opposite; SBM was negatively related to most positive health indices and positively related to several of the negative health indicators. The notable exception was that SBM was positively related to the quality of peer relationships. Although there were cross national differences in the strength of some relationships, these patterns were essentially replicated in both countries. Conclusions: Surveys of nationally representative samples of youth in two countries provide evidence of positive physical and social concomitants of PA and negative concomitants of SBM. These findings suggest potential positive consequences of increasing PA and decreasing SBM in adolescents and provide further justification for such efforts. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - adolescent physical activity
KW - screen-based media use
KW - social health
KW - physical health
KW - 2009
KW - Communications Media
KW - Health
KW - Health Behavior
KW - Physical Activity
KW - Adolescent Psychology
KW - 2009
U1 - Sponsor: US Agency for International Development, US. Grant: Cooperative Agreement GPO-A-00-03-00003-00. Other Details: With the MEASURE Evaluation project. Recipients: No recipient indicated
DO - 10.1016/j.jadohealth.2008.10.142
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06603-012&site=ehost-live&scope=site
UR - iannottr@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07979-015
AN - 2009-07979-015
AU - Pfefferle, Susan G.
AU - Cooper, Ben
AU - Layton, Debbie
AU - Rohrbach, Sharon
T1 - Early collaboration for adaptation: Addressing depression in low-income new mothers.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2009/05//
VL - 20
IS - 2
SP - 539
EP - 544
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Pfefferle, Susan G., 1 Brookings Dr., Box 1093, St. Louis, MO, US, 63130
N1 - Accession Number: 2009-07979-015. PMID: 19395847 Partial author list: First Author & Affiliation: Pfefferle, Susan G.; Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, MO, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Lower Income Level; Major Depression; Mental Health Services; Mothers. Minor Descriptor: Cooperation. Classification: Affective Disorders (3211). Population: Human (10); Female (40). Page Count: 6. Issue Publication Date: May, 2009.
AB - This paper describes the development and implementation of a collaborative research project between a community agency and university-based researcher. The goal of the project was to address depression in low-income new mothers who would not ordinarily have access to mental health services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - depression
KW - low income mothers
KW - mental health services
KW - research collaboration
KW - 2009
KW - Lower Income Level
KW - Major Depression
KW - Mental Health Services
KW - Mothers
KW - Cooperation
KW - 2009
DO - 10.1353/hpu.0.0134
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07979-015&site=ehost-live&scope=site
UR - spfefferle@gwbmail.wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08388-005
AN - 2009-08388-005
AU - Lowe, Brian D.
AU - Krieg, Edward F.
T1 - Relationships between observational estimates and physical measurements of upper limb activity.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2009/05//
VL - 52
IS - 5
SP - 569
EP - 583
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Lowe, Brian D., National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2009-08388-005. PMID: 19424924 Partial author list: First Author & Affiliation: Lowe, Brian D.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20090907. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Human Factors Engineering; Limbic System; Motor Processes. Classification: Motor Processes (2330); Engineering & Environmental Psychology (4000). Population: Human (10); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: May, 2009.
AB - [Correction Notice: An erratum for this article was reported in Vol 52(9) of Ergonomics (see record [rid]2009-17783-014[/rid]). This paper (Ergonomics 52 (5), pp. 569–583) contains an error in the interpretation of the Hand Activity Level (HAL) rating in relation to the measured hand force duty cycle.] This study examined the internal validity of observational-based ergonomic job analysis methods for assessing upper limb force exertion and repetitive motion. Six manual tasks were performed by multiple ‘workers’ while direct measurements were made to quantify force exertion and kinematics of the upper limb. Observational-based analyses of force and upper limb motion/repetition were conducted by 29 professional ergonomists. These analysts overestimated the magnitude of individual force exertions—temporal aspects of force exertion (duty cycle) were estimated more accurately. Estimates of the relative severity of repetitive motions among the jobs were accurate. Absolute counts of repetitive motions were less accurate. Modest correlations (r² = 0.28 to r² = 0.50) were observed between ratings of hand activity level and measured joint velocities. Ergonomic job analyses relying on systematic observation should be applied and interpreted with consideration given to the capabilities and limitations of analysts in estimating the physical risk factors. These findings are relevant to a better understanding of the internal validity of ergonomic job analysis methods based on systematic observation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - upper limb activity
KW - ergonomics
KW - motor processes
KW - 2009
KW - Human Factors Engineering
KW - Limbic System
KW - Motor Processes
KW - 2009
DO - 10.1080/00140130802449682
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08388-005&site=ehost-live&scope=site
UR - blowe@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06954-015
AN - 2009-06954-015
AU - Power, A. Kathryn
T1 - A public health model of mental health for the 21st century.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/05//
VL - 60
IS - 5
SP - 580
EP - 584
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Power, A. Kathryn, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 5600 Fishers Ln., Room 17-99, Rockville, MD, US, 20857
N1 - Accession Number: 2009-06954-015. PMID: 19411342 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Power, A. Kathryn; Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Release Date: 20090727. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Column/Opinion. Language: English. Major Descriptor: Health Promotion; Mental Health Services; Public Health; Treatment; Well Being. Minor Descriptor: Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 5. Issue Publication Date: May, 2009.
AB - In 2003 the President’s New Freedom Commission called for the transformation of the public mental health system to one that is person centered, recovery focused, evidence based, and quality driven. In this column the director of the Center for Mental Health Services describes progress made by the center over the past five years as well as challenges and opportunities. She presents a strategic forecast, based on stakeholder input, to guide policy formulation and resource allocation. Central to the forecast is the concept of a public health model of mental health that takes a community approach to prevention, treatment, and promotion of well-being. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - public health
KW - mental health
KW - Center for Mental Health Services
KW - treatment
KW - health promotion
KW - well being
KW - 2009
KW - Health Promotion
KW - Mental Health Services
KW - Public Health
KW - Treatment
KW - Well Being
KW - Mental Health
KW - 2009
DO - 10.1176/appi.ps.60.5.580
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06954-015&site=ehost-live&scope=site
UR - kpower@samhsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-12450-004
AN - 2009-12450-004
AU - Friedman, Bernard
AU - Encinosa, William
AU - Jiang, H. Joanna
AU - Mutter, Ryan
T1 - Do patient safety events increase readmissions?
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2009/05//
VL - 47
IS - 5
SP - 583
EP - 590
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Friedman, Bernard, 540 Gaither Rd, Rockville, MD, US, 20850
N1 - Accession Number: 2009-12450-004. PMID: 19318996 Partial author list: First Author & Affiliation: Friedman, Bernard; Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20100301. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Death and Dying; Hospital Admission; Risk Factors; Safety. Minor Descriptor: Patient Safety. Classification: Inpatient & Hospital Services (3379). Population: Human (10); Inpatient (50). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 2009. Copyright Statement: Lippincott Williams & Wilkins, Inc. 2009.
AB - Objective: Adverse safety events in the hospital could impose extra costs not only due to longer stays and corrective treatments, but also due to deaths and readmissions. The effects of safety events on readmissions have rarely been analyzed. Large, all-payer and all-diagnosis databases permit new tests. This study will simultaneously test the effects of safety events on risks of deaths and readmission. Study Design: The population is a selection of almost 1.5 million adult surgery patients initially treated in 1088 short stay hospitals. These are patients at risk for at least 1 of 9 types of patient safety event, as specified in software in the public domain from the Agency for Healthcare Research and Quality. The main data sources are 7 statewide databases of hospitalizations in 2004, maintained by Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. We control for many factors affecting readmission or death, particularly the severity of illness, chronic comorbidities, age, and payer group. Separate models are used for each type of safety event and a composite model is used for any safety event. Principal Findings: Among the patients at risk for any of the patient safety events, 2.6% had at least one safety event. The 3-month readmission rate was about 17% for those with no safety event, but about 25% when a safety event was recorded. The corresponding rates for readmission within 1 month were 11% and 16%. The in-hospital death rate was 1.3% with no safety event, but 9.2% with a safety event. After risk adjustment, the relative risk of readmission within 3 months was about 1.20 (P < 0.01), ranging from 1.14 to 1.56 for specific types of events. The risk-adjusted result for readmission within 1 month associated with at least one safety event was 1.17 (P < 0.01). However, the models for specific safety events gave a significantly high risk of readmission within 1 month for only 2 of the more common types of safety events. Conclusions: Hospital readmissions are one way that safety events can have costly consequences. More attention is warranted to assess the full extra cost of safety events, the factors influencing the rate of safety events, and strategies for health plans to improve incentives for safety. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - patient safety
KW - risk of death & hospital readmissions
KW - 2009
KW - Death and Dying
KW - Hospital Admission
KW - Risk Factors
KW - Safety
KW - Patient Safety
KW - 2009
DO - 10.1097/MLR.0b013e31819434da
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-12450-004&site=ehost-live&scope=site
UR - bernard.friedman@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08388-007
AN - 2009-08388-007
AU - Lee, Soo-Jin
AU - Kong, Yong-Ku
AU - Lowe, Brian D.
AU - Song, Seongho
T1 - Handle grip span for optimising finger-specific force capability as a function of hand size.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2009/05//
VL - 52
IS - 5
SP - 601
EP - 608
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
N1 - Accession Number: 2009-08388-007. PMID: 19424925 Partial author list: First Author & Affiliation: Lee, Soo-Jin; College of Medicine, Hanyang University, Seoul, Korea. Release Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Motor Processes; Physical Strength; Tactual Perception. Classification: Motor Processes (2330). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: May, 2009.
AB - Five grip spans (45 to 65 mm) were tested to evaluate the effects of handle grip span and user’s hand size on maximum grip strength, individual finger force and subjective ratings of comfort using a computerised digital dynamometer with independent finger force sensors. Forty-six males participated and were assigned into three hand size groups (small, medium, large) according to their hands’ length. In general, results showed the 55- and 50-mm grip spans were rated as the most comfortable sizes and showed the largest grip strength (433.6 N and 430.8 N, respectively), whereas the 65-mm grip span handle was rated as the least comfortable size and the least grip strength. With regard to the interaction effect of grip span and hand size, small and medium-hand participants rated the best preference for the 50- to 55-mm grip spans and the least for the 65-mm grip span, whereas large-hand participants rated the 55- to 60-mm grip spans as the most preferred and the 45-mm grip span as the least preferred. Normalised grip span (NGS) ratios (29% and 27%) are the ratios of user’s hand length to handle grip span. The NGS ratios were obtained and applied for suggesting handle grip spans in order to maximise subjective comfort as well as gripping force according to the users’ hand sizes. In the analysis of individual finger force, the middle finger force showed the highest contribution (37.5%) to the total finger force, followed by the ring (28.7%), index (20.2%) and little (13.6%) finger. In addition, each finger was observed to have a different optimal grip span for exerting the maximum force, resulting in a bow-contoured shaped handle (the grip span of the handle at the centre is larger than the handle at the end) for two-handle hand tools. Thus, the grip spans for two-handle hand tools may be designed according to the users’ hand/finger anthropometrics to maximise subjective ratings and performance based on this study. Results obtained in this study will provide guidelines for hand tool designers and manufacturers for designing grip spans of two-handle tools, which can maximise handle comfort and performance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - handle grip span
KW - optimizing finger specific force capability
KW - hand size
KW - 2009
KW - Motor Processes
KW - Physical Strength
KW - Tactual Perception
KW - 2009
U1 - Sponsor: Korea Government, MOST, Korea Science and Engineering Foundation (KOSEF), Korea. Grant: R01–2007–000–10915–0. Recipients: No recipient indicated
DO - 10.1080/00140130802422481
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08388-007&site=ehost-live&scope=site
UR - ykong@skku.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07061-004
AN - 2009-07061-004
AU - van Rooij, Floor B.
AU - van Balen, Frank
AU - Hermanns, Jo M. A.
T1 - The experiences of involuntarily childless Turkish immigrants in the Netherlands.
JF - Qualitative Health Research
JO - Qualitative Health Research
JA - Qual Health Res
Y1 - 2009/05//
VL - 19
IS - 5
SP - 621
EP - 632
CY - US
PB - Sage Publications
SN - 1049-7323
SN - 1552-7557
N1 - Accession Number: 2009-07061-004. PMID: 19270194 Partial author list: First Author & Affiliation: van Rooij, Floor B.; Public Health Service of Amsterdam, Amsterdam, Netherlands. Release Date: 20100125. Correction Date: 20111114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Childlessness; Immigration; Infertility; Life Experiences. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 12. Issue Publication Date: May, 2009. Copyright Statement: The Author(s). 2009.
AB - The consequences of involuntary childlessness are influenced by culture in several ways. In this study we explored the experiences and responses of infertile Turkish immigrants in the Netherlands. Twenty in-depth interviews were conducted with involuntarily childless Turkish immigrants in the Netherlands (11 couples and 9 women). Interviews were transcribed verbatim and were analyzed using interpretative phenomenological analysis (IPA). The respondents’ experiences were clustered around six superordinate themes: effects on self; effects on the relationship with the partner; effects on the relationship with others; disclosure; coping; and the future. Most transcripts revealed that involuntary childlessness has a profound negative influence on multiple aspects of the lives of the respondents. Strong pronatalist ideology, misconceptions about infertility and treatment, and migration-related aspects such as language difficulties, appear to play a role in the negative experiences of Turkish immigrants. Respondents reported several ways of coping (to some extent) with these negative experiences. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - involuntarily childless
KW - infertile Turkish immigrants
KW - experiences
KW - Netherlands
KW - 2009
KW - Childlessness
KW - Immigration
KW - Infertility
KW - Life Experiences
KW - 2009
DO - 10.1177/1049732309333242
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07061-004&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07575-015
AN - 2009-07575-015
AU - Chander, Geetanjali
AU - Himelhoch, Seth
AU - Fleishman, John A.
AU - Hellinger, James
AU - Gaist, Paul
AU - Moore, Richard D.
AU - Gebo, Kelly A.
T1 - HAART receipt and viral suppression among HIV-infected patients with co-occurring mental illness and illicit drug use.
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2009/05//
VL - 21
IS - 5
SP - 655
EP - 663
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
N1 - Accession Number: 2009-07575-015. PMID: 19444675 Partial author list: First Author & Affiliation: Chander, Geetanjali; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, US. Release Date: 20090824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Gebo, Kelly A. Major Descriptor: Drug Therapy; Drug Usage; HIV; Mental Disorders; Patients. Minor Descriptor: Antiviral Drugs; Comorbidity. Classification: Medical Treatment of Physical Illness (3363); Psychological & Physical Disorders (3200). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: May, 2009.
AB - Mental illness (MI) and illicit drug use (DU) frequently co-occur. We sought to determine the individual and combined effects of MI and DU on highly active antiretroviral therapy (HAART) receipt and HIV-RNA suppression among individuals engaged in HIV care. Using 2004 data from the HIV Research Network (HIVRN), we performed a cross-sectional study of HIV-infected patients followed at seven primary care sites. Outcomes of interest were HAART receipt and virological suppression, defined as an HIV-RNA <400 copies/ml. Independent variables of interest were: (1) MI/DU; (2) DU only; (3) MI only; and (4) Neither. We used chi squared analysis for comparison of categorical variables, and logistic regression to adjust for age, race, sex, frequency of outpatient visits, years in clinical care, CD4 nadir, and study site. During 2004, 10,284 individuals in the HIVRN were either on HAART or HAART eligible defined as a CD4 cell count ≤350. Nearly half had neither MI nor DU (41%), 22% MI only, 15% DU only, and 22% both MI and DU. In multivariate analysis, cooccurring MI/DU was associated with the lowest odds of HAART receipt (Adjusted Odds Ratio: 0.63 (95% CI: (0.55-0.72]), followed by those with DU only (0.75(0.63-0.87)), compared to those with neither. Among those on HAART, concurrent MI/DU (0.66 (0.58-0.75)), DU only (0.77 (0.67-0.88)), were also associated with a decreased odds of HIV-RNA suppression compared to those with neither. MI only was not associated with a statistically significant decrease in HAART receipt (0.93 (0.81-1.07)) or viral suppression (0.93 (0.82-1.05)) compared to those with neither. Post-estimation testing revealed a significant difference between those with MI/DU and DU only, and MI/DU and MI only. Co-occurring MI and DU is associated with lower HAART receipt and viral suppression compared to individuals with either MI or DU or neither. Integrating HIV, substance abuse, and mental healthcare may improve outcomes in this population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - highly active antiretroviral therapy
KW - illicit drug use
KW - mental illness
KW - viral suppression
KW - HIV infected patients
KW - 2009
KW - Drug Therapy
KW - Drug Usage
KW - HIV
KW - Mental Disorders
KW - Patients
KW - Antiviral Drugs
KW - Comorbidity
KW - 2009
U1 - Sponsor: Agency for Healthcare Research and Quality. Grant: 290-01-0012. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: K23-DA00523; K-23-DA019820; K24- DA00432. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Grant: K23 AA015313. Recipients: No recipient indicated
U1 - Sponsor: Johns Hopkins University, US. Other Details: Richard Ross Clinician Scientist Award. Recipients: Gebo, Kelly A.
DO - 10.1080/09540120802459762
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07575-015&site=ehost-live&scope=site
UR - GChande1@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06904-006
AN - 2009-06904-006
AU - Casanova, Manuel F.
AU - El-Baz, Ayman
AU - Mott, Meghan
AU - Mannheim, Glenn
AU - Hassan, Hossam
AU - Fahmi, Rachid
AU - Giedd, Jay
AU - Rumsey, Judith M.
AU - Switala, Andrew E.
AU - Farag, Aly
T1 - Reduced gyral window and corpus callosum size in autism: Possible macroscopic correlates of a minicolumnopathy.
JF - Journal of Autism and Developmental Disorders
JO - Journal of Autism and Developmental Disorders
JA - J Autism Dev Disord
Y1 - 2009/05//
VL - 39
IS - 5
SP - 751
EP - 764
CY - Germany
PB - Springer
SN - 0162-3257
SN - 1573-3432
AD - Casanova, Manuel F., Department of Psychiatry, University of Louisville, 500 South Preston St. Bldg. 55A Ste 210, Louisville, KY, US, 40292
N1 - Accession Number: 2009-06904-006. PMID: 19148739 Other Journal Title: Journal of Autism & Childhood Schizophrenia. Partial author list: First Author & Affiliation: Casanova, Manuel F.; Department of Psychiatry, University of Louisville, Louisville, KY, US. Other Publishers: Plenum Publishing Corp.; Scripta Publishing Corporation; VH Winston & Son. Release Date: 20090727. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Autism Spectrum Disorders; Brain; Corpus Callosum; Magnetic Resonance Imaging. Classification: Developmental Disorders & Autism (3250). Population: Human (10); Male (30). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: WAIS-R (Wechsler Adult Intelligence Scale-Revised); Autism Diagnostic Interview. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: May, 2009.
AB - Minicolumnar changes that generalize throughout a significant portion of the cortex have macroscopic structural correlates that may be visualized with modern structural neuroimaging techniques. In magnetic resonance images (MRIs) of fourteen autistic patients and 28 controls, the present study found macroscopic morphological correlates to recent neuropathological findings suggesting a minicolumnopathy in autism. Autistic patients manifested a significant reduction in the aperture for afferent/efferent cortical connections, i.e., gyral window. Furthermore, the size of the gyral window directly correlated to the size of the corpus callosum. A reduced gyral window constrains the possible size of projection fibers and biases connectivity towards shorter corticocortical fibers at the expense of longer association/commisural fibers. The findings may help explain abnormalities in motor skill development, differences in postnatal brain growth, and the regression of acquired functions observed in some autistic patients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - gyral windows
KW - corpus callosum
KW - autism
KW - minicolumnopathy
KW - magnetic resonance images
KW - 2009
KW - Autism Spectrum Disorders
KW - Brain
KW - Corpus Callosum
KW - Magnetic Resonance Imaging
KW - 2009
DO - 10.1007/s10803-008-0681-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06904-006&site=ehost-live&scope=site
UR - manuel.casanova@louisville.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Mun, Seong K.
AU - Pak, Hon
AU - Clyburn, Conrad
AU - Collmann, Jeff
AU - Tohme, Walid
AU - Levine, Betty A.
T1 - The Executive Summary of the National Forum on the Future of Defense Health Information Systems.
JO - Military Medicine
JF - Military Medicine
Y1 - 2009/05/02/May2009 Supplement
M3 - Article
SP - 1
EP - 3
PB - AMSUS
SN - 00264075
AB - The Department of Defense (DoD) has been engaged in the development and deployment of the longitudinal health record (LHR), It has achieved remarkable technological success by handling vast amounts of patient data coming from clinical sites around the globe. Interoperability between DoD and VA has improved and this information sharing capability is expected to continue to expand as the defense health information system becomes an integral part of the national network. On the other hand, significant challenges remain in terms of user acceptance, ability to incorporate innovations, software acquisition methodology, and overall systems architecture. [ABSTRACT FROM AUTHOR]
AB - Copyright of Military Medicine is the property of AMSUS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL records
KW - LONGITUDINAL method
KW - MILITARY medicine
KW - INTERNETWORKING (Telecommunication)
KW - INFORMATION sharing
KW - MEDICAL informatics
KW - UNITED States
KW - UNITED States. Dept. of Defense
N1 - Accession Number: 40828438; Mun, Seong K. 1 Pak, Hon 2 Clyburn, Conrad 3 Collmann, Jeff 3 Tohme, Walid 3 Levine, Betty A. 3; Affiliation: 1: Institute of Advanced Study, Virginia Tech, 1101 King Street (#610), Alexandria, VA 22314 2: Imaging Science and Information Systems Center, Georgetown University, 2115 Wisconsin Avenue, NW. Suite 603, Washington, DC 20057 3: Office of the Surgeon General, 5109 Leesburgh Pike, Suite 595, Sky 6, Falls Church, VA 22041; Source Info: May2009 Supplement, p1; Subject Term: MEDICAL records; Subject Term: LONGITUDINAL method; Subject Term: MILITARY medicine; Subject Term: INTERNETWORKING (Telecommunication); Subject Term: INFORMATION sharing; Subject Term: MEDICAL informatics; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Defense; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40828438&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Witkop, Catherine Takacs
AU - Miller, Therese
AU - Syed, Shamsuzzoha B.
T1 - Folic Acid Supplementation for the Prevention of Neural Tube Defects: An Update of the Evidence for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/05/05/
VL - 150
IS - 9
M3 - Article
SP - 632
EP - W:115
SN - 00034819
AB - Background: Neural tube defects (NTDs) are among the most common birth defects in the United States. In 1996, the U.S. Preventive Services Task Force (USPSTF) recommended that all women planning a pregnancy or capable of conception take a supplement containing folic acid to reduce the risk for NTDs. Purpose: To search for new evidence published since 1996 on the benefits and harms of folic acid supplementation for women of childbearing age to prevent neural tube defects in offspring, to inform an updated USPSTF recommendation. Data Sources: MEDLINE and Cochrane Central Register of Controlled Trials searches from January 1995 through December 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. Study Selection: English-language randomized, controlled trials; cohort studies; case-control studies; systematic reviews; and metaanalyses were selected if they provided information on the benefits and harms of folic acid supplementation in women of childbearing age to reduce NTDs in offspring. Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: Four observational studies reported benefit of reduction of risk for NTDs associated with folic acid-containing supplements. Differences in study type and methods prevent the calculation of a summary of the reduction in risk. The one included study on harms reported that the association of twinning with folic acid intake disappeared after adjustment for in vitro fertilization and underreporting of folic acid intake. Limitations: The evidence on dose was limited. No evidence was found on the potential harm of masking vitamin B12 deficiency in women of childbearing age. The search focused on the association of NTDs with supplementation only and therefore does not provide a comprehensive review of the effects of folic acid on all possible outcomes or of the effects of dietary intake of folic acid. Conclusion: New observational evidence supports previous evidence from a randomized, controlled trial that folic acid-containing supplements reduce the risk for NTD-affected pregnancies. The association of folic acid use with twin gestation may be confounded by fertility interventions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - NEURAL tube -- Abnormalities
KW - HUMAN abnormalities
KW - PREGNANT women -- Health
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 39342109; Wolff, Tracy 1 Witkop, Catherine Takacs 2 Miller, Therese 1 Syed, Shamsuzzoha B. 3; Affiliation: 1: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Preventive Medicine/OB/Gyn, 10 AMDS, 2355 Faculty Drive, Room 2N286, U.S. Air Force Academy, CO 80840 3: Johns Hopkins Bloomberg School of Public Health, Preventive Medicine Residency Program, 615 North Wolfe Street, Room WB602, Baltimore, MD 21205-1996; Source Info: 5/5/2009, Vol. 150 Issue 9, p632; Subject Term: FOLIC acid; Subject Term: NEURAL tube -- Abnormalities; Subject Term: HUMAN abnormalities; Subject Term: PREGNANT women -- Health; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 12p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39342109&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Witkop, Catherine Takacs
AU - Miller, Therese
AU - Syed, Shamsuzzoha B.
T1 - Folic Acid Supplementation for the Prevention of Neural Tube Defects: An Update of the Evidence for the U.S. Preventive Services Task Force.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/05/05/
VL - 150
IS - 9
M3 - Article
SP - 632
EP - W:115
SN - 00034819
AB - Background: Neural tube defects (NTDs) are among the most common birth defects in the United States. In 1996, the U.S. Preventive Services Task Force (USPSTF) recommended that all women planning a pregnancy or capable of conception take a supplement containing folic acid to reduce the risk for NTDs. Purpose: To search for new evidence published since 1996 on the benefits and harms of folic acid supplementation for women of childbearing age to prevent neural tube defects in offspring, to inform an updated USPSTF recommendation. Data Sources: MEDLINE and Cochrane Central Register of Controlled Trials searches from January 1995 through December 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. Study Selection: English-language randomized, controlled trials; cohort studies; case-control studies; systematic reviews; and metaanalyses were selected if they provided information on the benefits and harms of folic acid supplementation in women of childbearing age to reduce NTDs in offspring. Data Extraction: All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. Data Synthesis: Four observational studies reported benefit of reduction of risk for NTDs associated with folic acid-containing supplements. Differences in study type and methods prevent the calculation of a summary of the reduction in risk. The one included study on harms reported that the association of twinning with folic acid intake disappeared after adjustment for in vitro fertilization and underreporting of folic acid intake. Limitations: The evidence on dose was limited. No evidence was found on the potential harm of masking vitamin B12 deficiency in women of childbearing age. The search focused on the association of NTDs with supplementation only and therefore does not provide a comprehensive review of the effects of folic acid on all possible outcomes or of the effects of dietary intake of folic acid. Conclusion: New observational evidence supports previous evidence from a randomized, controlled trial that folic acid-containing supplements reduce the risk for NTD-affected pregnancies. The association of folic acid use with twin gestation may be confounded by fertility interventions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOLIC acid
KW - NEURAL tube -- Abnormalities
KW - HUMAN abnormalities
KW - PREGNANT women -- Health
KW - U.S. Preventive Services Task Force
KW - UNITED States
N1 - Accession Number: 39342109; Wolff, Tracy 1; Witkop, Catherine Takacs 2; Miller, Therese 1; Syed, Shamsuzzoha B. 3; Source Information: 5/5/2009, Vol. 150 Issue 9, p632; Subject: FOLIC acid; Subject: NEURAL tube -- Abnormalities; Subject: HUMAN abnormalities; Subject: PREGNANT women -- Health; Subject: U.S. Preventive Services Task Force; Geographic Terms: UNITED States; Number of Pages: 12p; Illustrations: 2 Diagrams, 4 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=39342109&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Pei Zhang
AU - Zhong, Lilin
AU - Struble, Evi Budo
AU - Watanabe, Hisayoshi
AU - Kachko, Alla
AU - Mihalik, Kathleen
AU - Virata-Thiemer, Maria Luisa
AU - Alter, Harvey J.
AU - Feinstone, Stephen
AU - Major, Marian
T1 - Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2009/05/05/
VL - 106
IS - 18
M3 - Article
SP - 7537
EP - 7541
SN - 00278424
AB - Using human immune globulins made from antihepatitis C virus (HCV)-positive plasma, we recently identified two antibody epitopes in the E2 protein at residues 412-426 (epitope I) and 434-446 (epitope II). Whereas epitope I is highly conserved among genotypes, epitope II varies. We discovered that epitope I was implicated in HCV neutralization whereas the binding of nonneutralizing antibody to epitope II disrupted virus neutralization mediated by antibody binding at epitope I. These findings suggested that, if this interfering mechanism operates in vivo during HCV infection, a neutralizing antibody against epitope I can be restrained by an interfering antibody, which may account for the persistence of HCV even in the presence of an abundance of neutralizing antibodies. We tested this hypothesis by affinity depletion and peptide-blocking of epitope-Il-specific antibodies in plasma of a chronically HCV-infected patient and recombinant E1E2 vaccinated chimpanzees. We demonstrate that, by removing the restraints imposed by the interfering antibodies to epitope-Il, neutralizing activity can be revealed in plasma that previously failed to neutralize viral stock in cell culture. Further, cross-genotype neutralization could be generated from monospecific plasma. Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMMUNOGLOBULINS
KW - HEPATITIS C
KW - PATIENTS
KW - HEPATITIS C virus
KW - NEUTRALIZATION (Chemistry)
KW - CHIMPANZEES
KW - ANTIGENIC determinants
KW - CELL culture
N1 - Accession Number: 40516509; Pei Zhang 1; Email Address: pei.zhang@fda.hhs.gov Zhong, Lilin 1 Struble, Evi Budo 1 Watanabe, Hisayoshi 2 Kachko, Alla 2 Mihalik, Kathleen 2 Virata-Thiemer, Maria Luisa 1 Alter, Harvey J. 3; Email Address: halter@mail.nih.gov Feinstone, Stephen 2 Major, Marian 2; Email Address: marian.major@fda.hhs.gov; Affiliation: 1: Division of Hematology, United States Food and Drug Administration, Bethesda, MD 20892, USA 2: Division of Viral Products and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA 3: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: 5/5/2009, Vol. 106 Issue 18, p7537; Subject Term: IMMUNOGLOBULINS; Subject Term: HEPATITIS C; Subject Term: PATIENTS; Subject Term: HEPATITIS C virus; Subject Term: NEUTRALIZATION (Chemistry); Subject Term: CHIMPANZEES; Subject Term: ANTIGENIC determinants; Subject Term: CELL culture; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiaoqing He
AU - Qiang Ma
T1 - Induction of Metallothionein I by Arsenic via Metal-activated Transcription Factor 1.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/05/08/
VL - 284
IS - 19
M3 - Article
SP - 12609
EP - 12621
SN - 00219258
AB - Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. The mechanism of MTF1 activation has not been well understood. We analyzed the interaction between arsenic (As3+) and MTF1 for Mt1 induction. Asa3+ potently induces Mt1 mRNA expression in mouse hepa1c1c7 cells. Induction is dependent upon functional MTF1 as induction is lost in Mtf1 knockout cells but is restored upon reconstitution with Mtf1; moreover, As3+ induces the binding of MTF1 to the metal response elements of endogenous Mt1. Induction is not affected by modulating zinc concentrations but is markedly enhanced by cycloheximide. Phenylarsine oxide(PAO), which covalently binds to vicinal protein cysteine thiol groups, induces Mt1 with a magnitude of higher potency than that of As3+. PAO affinity beads effectively pulls down the carboxyl half of MTF1 (MTF1321-675) by binding to a cluster of five!cysteine residues near the terminus. Preincubation with As3+, Cd2+, Co2+, Ni2+, Ag+, Hg2+, and Bi3+ blocks pulldown of MTF1321-675 by PAO beads in vitro and in vivo, indicating that binding of the metal inducers to the same C-terminal cysteine cluster as PAO occurs. Deletion of the C-terminal cysteine cluster or mutation of the cysteine residues abolishes or markedly reduces the transcription activation activity of MTF1 and the ability of MTF1 to restore Mt1 induction in Mtf1 knockout cells. The findings demonstrate a critical role of the C-terminal cysteine cluster of MTF1 in arsenic sensing and gene transcription via arsenic-cysteine thiol interaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METALLOTHIONEIN
KW - ZINC
KW - ARSENIC
KW - METALLOPROTEINS
KW - CARBOXYLIC acids
KW - CYSTEINE proteinases
KW - THIOLS
N1 - Accession Number: 40220940; Xiaoqing He 1 Qiang Ma 1,2; Email Address: qam1@cdc.gov; Affiliation: 1: Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, West Virginia University School of Medicine, Morgantown, West Virginia 26505 2: Department of Biochemistry, West Virginia University School of Medicine, Morgantown, West Virginia 26505; Source Info: 5/8/2009, Vol. 284 Issue 19, p12609; Subject Term: METALLOTHIONEIN; Subject Term: ZINC; Subject Term: ARSENIC; Subject Term: METALLOPROTEINS; Subject Term: CARBOXYLIC acids; Subject Term: CYSTEINE proteinases; Subject Term: THIOLS; NAICS/Industry Codes: 212393 Other Chemical and Fertilizer Mineral Mining; NAICS/Industry Codes: 212398 All other non-metallic mineral mining and quarrying; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 13p; Illustrations: 13 Graphs; Document Type: Article
L3 - 10.1074/jbc.M901204200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yaqin Zhang
AU - Rosado, Leslie A. Rivera
AU - Sun Young Moon
AU - Baolin Zhang
T1 - Silencing of D4-GDI Inhibits Growth and Invasive Behavior in MDA-MB-231 Cells by Activation of Rac-dependent p38 and JNK Signaling.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/05/08/
VL - 284
IS - 19
M3 - Article
SP - 12956
EP - 12965
SN - 00219258
AB - The Rho GDP dissociation inhibitor D4-GDI is overexpressed in some human breast cancer cell lines (Zhang, Y., and Zhang, B. (2006) Cancer Res. 66,5592-5598). Here, we show that silencing of D4-GDI by RNA interference abrogates tumor growth and lung metastasis of otherwise highly invasive MDA-MB-231 breast cancer cells. Under anchorage-independent culture conditions, D4-GDI-depleted cells undergo rapid apoptosis (anoikis), which is known to hinder metastasis. We also found that D4-GDI associates with Rac1 and Rac3 in breast cancer cells, but not with other Rho GTPases tested (Cdc42, RhoA, RhoC, and TC10). Silencing of D4-GDI results in constitutive Rac1 activation and translocation from the cytosol to cellular membrane compartments and in sustained activation of p38 and JNK kinases. Rac1 blockade inhibits p38/JNK kinase activities and the spontaneous anoikis of D4-GDI knockdown cells. These results suggest that D4-GDI regulates cell function by interacting primarily with Rac GTPases and may play an integral role in breast cancer tumorigenesis. D4-GDI could prove to be a potential new target for therapeutic intervention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BREAST cancer
KW - CANCER cells
KW - APOPTOSIS
KW - CYTOSOL
KW - JNK mitogen-activated protein kinases
N1 - Accession Number: 40220977; Yaqin Zhang 1 Rosado, Leslie A. Rivera 1 Sun Young Moon 1 Baolin Zhang 1; Email Address: Baolin.zhang@fda.hhs.gov; Affiliation: 1: Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 5/8/2009, Vol. 284 Issue 19, p12956; Subject Term: BREAST cancer; Subject Term: CANCER cells; Subject Term: APOPTOSIS; Subject Term: CYTOSOL; Subject Term: JNK mitogen-activated protein kinases; Number of Pages: 10p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1074/jbc.M807845200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weisz, Adrian
AU - Mazzola, Eugene P.
AU - Ito, Yoichiro
T1 - Preparative separation of di- and trisulfonated components of Quinoline Yellow using affinity-ligand pH-zone-refining counter-current chromatography
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2009/05/08/
VL - 1216
IS - 19
M3 - Article
SP - 4161
EP - 4168
SN - 00219673
AB - Abstract: Four positionally isomeric 2-(2-quinolinyl)-1H-indene-1,3(2H)-dionedisulfonic acids (SA) and one triSA, components of the color additive Quinoline Yellow (QY, Color Index No. 47005), were isolated from the dye mixture by affinity-ligand pH-zone-refining counter-current chromatography (CCC) through complementary use of ion-exchange and ion-pair reagents as the ligand. The added ligands facilitated the partitioning of the very polar polysulfonated components into the organic stationary phase of the two-phase solvent systems that consisted of isoamyl alcohol–methyl tert-butyl ether–acetonitrile–water (3:5:1:7), (3:4:1:7) or (3:1:1:5). Thus, separation of a 5-g portion of QY using sulfuric acid as the retainer and dodecylamine as the ligand (an ion-exchange reagent, 20% in the stationary phase), resulted in 1.21g of 6′,5-diSA and 1.69g of 6′,8′,5-triSA, both of over 99% purity. A minor component, 8′,4-diSA, not previously reported was also obtained (4.8mg of over 94% purity) through a similar separation of a different batch of QY using hydrochloric acid as the retainer and 10% dodecylamine as the ligand in the stationary phase. Two components that co-eluted (0.55g) in the 5g separation were separated when trifluoroacetic acid was used as the retainer and tetrabutylammonium hydroxide (an ion-pair reagent) as the ligand. The separation resulted in 20.7mg of 6′,4-diSA, not previously reported, and 111.8mg of 8′,5-diSA, both of over 98% purity. The isolated compounds were characterized by high-resolution mass spectrometry and proton nuclear magnetic resonance with correlated spectroscopy assignments. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEPARATION (Technology)
KW - CHROMATOGRAPHIC analysis
KW - SULFONIC acids
KW - ADDITIVES
KW - DYES & dyeing
KW - ION exchange (Chemistry)
KW - OPTICAL isomers
KW - LIGANDS
KW - AFFINITY chromatography
KW - STATIONARY phase (Chromatography)
KW - HIGH resolution spectroscopy
KW - Counter-current chromatography
KW - D&C Yellow No. 10
KW - Disulfonic acids
KW - Dyes
KW - Isomers
KW - Ligand
KW - NMR
KW - pH-zone-refining CCC
KW - Quinoline Yellow
KW - Sulfonic acids
KW - Trisulfonic acid
N1 - Accession Number: 37815358; Weisz, Adrian 1; Email Address: adrian.weisz@fda.hhs.gov Mazzola, Eugene P. 2 Ito, Yoichiro 3; Affiliation: 1: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA 2: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA 3: Bioseparation Technology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: May2009, Vol. 1216 Issue 19, p4161; Subject Term: SEPARATION (Technology); Subject Term: CHROMATOGRAPHIC analysis; Subject Term: SULFONIC acids; Subject Term: ADDITIVES; Subject Term: DYES & dyeing; Subject Term: ION exchange (Chemistry); Subject Term: OPTICAL isomers; Subject Term: LIGANDS; Subject Term: AFFINITY chromatography; Subject Term: STATIONARY phase (Chromatography); Subject Term: HIGH resolution spectroscopy; Author-Supplied Keyword: Counter-current chromatography; Author-Supplied Keyword: D&C Yellow No. 10; Author-Supplied Keyword: Disulfonic acids; Author-Supplied Keyword: Dyes; Author-Supplied Keyword: Isomers; Author-Supplied Keyword: Ligand; Author-Supplied Keyword: NMR; Author-Supplied Keyword: pH-zone-refining CCC; Author-Supplied Keyword: Quinoline Yellow; Author-Supplied Keyword: Sulfonic acids; Author-Supplied Keyword: Trisulfonic acid; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.chroma.2009.02.064
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chestnutt, I. G.
AU - Davies, L.
AU - Thomas, D. R.
T1 - Practitioners' perspectives and experiences of the new National Health Service dental contract.
JO - British Dental Journal
JF - British Dental Journal
Y1 - 2009/05/09/
VL - 206
IS - 9
M3 - Article
SP - E18
EP - E18
SN - 00070610
AB - Background In April 2006, fundamental changes were made to the arrangements for commissioning state funded (National Health Service, NHS) dental care in England and Wales. These involved the dissolution of a universal national contract and the introduction of locally commissioned primary dental care services. Suggested advantages included the elimination of a fee-for-item 'treadmill', an increased emphasis on prevention and improved patient access. This change came at a time when many practitioners were opting to provide care outside the NHS.Objectives This study investigated dentists' experience of the new contract and compared this with attitudes determined in a previous survey of the same cohort of dentists conducted immediately before the changed commissioning arrangements.Methods Data were collected via a postal questionnaire, comprising a combination of 60 open and closed questions, mailed to 608 general dental practitioners in Wales.Results Four hundred and ninety-six (77%) questionnaires were returned. Four hundred and seventeen practitioners continued to provide NHS dental care. Only 46 (11%) of the 417 practitioners agreed that they liked the new method of remuneration and the majority (362 [86.8%]) perceived that they still delivered state-funded care in a 'treadmill' environment. This compares with 34.9% of dentists who perceived the new system as a 'treadmill' immediately before its implementation. Three hundred and forty-eight (83.4%) disagreed that they were able to spend more time on prevention and 356 (85.3%) did not feel they had more time to spend with patients – key objectives of the reforms. Two hundred and seventy-five (65.9%) respondents agreed that local NHS commissioners were controlling their business.Conclusion This survey, conducted 18 months after the implementation of the new commissioning arrangements, suggests that practitioners are deeply unhappy with local commissioning. It raises questions as to whether the changes have achieved the Government's stated objectives in reforming state-funded primary dental care. [ABSTRACT FROM AUTHOR]
AB - Copyright of British Dental Journal is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DENTAL care
KW - HEALTH services administration
KW - DENTISTS
KW - DENTAL personnel
KW - ENGLAND
KW - WALES
N1 - Accession Number: 39260430; Chestnutt, I. G. 1 Davies, L. 2 Thomas, D. R. 3; Affiliation: 1: Professor and Honorary Consultant in Public Dental Health, Cardiff University Dental School, Heath Park, Cardiff, CF14 4XY 2: Research Associate, Dental Public Health Unit, Cardiff University Dental School, Heath Park, Cardiff, CF14 4XY 3: Consultant in Dental Public Health, National Public Health Service for Wales, Mamhilad House, Mamhilad Park Estate, Pontypool, NP4 0YP; Source Info: 5/9/2009, Vol. 206 Issue 9, pE18; Subject Term: DENTAL care; Subject Term: HEALTH services administration; Subject Term: DENTISTS; Subject Term: DENTAL personnel; Subject Term: ENGLAND; Subject Term: WALES; NAICS/Industry Codes: 621210 Offices of Dentists; NAICS/Industry Codes: 339116 Dental Laboratories; NAICS/Industry Codes: 339114 Dental Equipment and Supplies Manufacturing; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 1p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1038/sj.bdj.2009.354
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105349531
T1 - Screening for iron deficiency anemia--including iron supplementation for children and pregnant women.
AU - Mabry-Hernandez IR
Y1 - 2009/05/15/
N1 - Accession Number: 105349531. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Anemia, Iron Deficiency -- Diagnosis
KW - Anemia, Iron Deficiency -- Therapy
KW - Iron Compounds -- Therapeutic Use
KW - Pregnancy Complications, Hematologic -- Diagnosis
KW - Pregnancy Complications, Hematologic -- Therapy
KW - Adult
KW - Anemia, Iron Deficiency -- Complications
KW - Child
KW - Female
KW - Health Screening
KW - Male
KW - Pregnancy Complications, Hematologic -- Etiology
KW - Pregnancy
SP - 897
EP - 898
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 10
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - IRIS R. MABRY-HERNANDEZ, MD,U.S. Preventive Services Task Force Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19496390.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - FORESTER, CRYSTAL D.
AU - WELLS, J. RAYMOND
T1 - Yields of Carbonyl Products from Gas-Phase Reactions of Fragrance Compounds with OH Radical and Ozone.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2009/05/15/
VL - 43
IS - 10
M3 - Article
SP - 3561
EP - 3568
SN - 0013936X
AB - Chamber studies to quantify formation yields of oxygenated organic reaction products were performed for gas-phase reactions of the hydroxyl radical (OH·) and ozone (O3) with the common cleaning product terpene compounds limonene, α-terpineol, and geraniol. The reaction products observed were identified and quantified using derivatization by O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and gas chromatography/mass spectrometry. Limonene rate constants and product mechanisms have been examined previously. Several of these investigations have measured product yields from limonene reactions and those results are compared with the results presented here. Although rate constants and product mechanisms have previously been investigated for α-terpineol and geraniol, yields of oxygenated organic reaction products have not been measured. Reactions from the fragrance compounds in this study produced several dicarbonyl reaction products such as glyoxal, methylglyoxal, and 4-oxopentanal which were observed from all three terpenes. Total carbonyl yields ranged from 5.1% for the limonene + O3 reaction to 92% for the geraniol + O3 reaction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Ozone
KW - Terpenes
KW - Research
KW - Gas chromatography/Mass spectrometry (GC-MS)
KW - Organic reaction mechanisms
KW - Cleaning compounds -- Environmental aspects
KW - Hydroxyl group
KW - METHODOLOGY
KW - Derivatization
N1 - Accession Number: 40741922; FORESTER, CRYSTAL D. 1; WELLS, J. RAYMOND 1; Email Address: ozwo@cdc.gov; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505.; Issue Info: 5/15/2009, Vol. 43 Issue 10, p3561; Thesaurus Term: Ozone; Thesaurus Term: Terpenes; Thesaurus Term: Research; Thesaurus Term: Gas chromatography/Mass spectrometry (GC-MS); Subject Term: Organic reaction mechanisms; Subject Term: Cleaning compounds -- Environmental aspects; Subject Term: Hydroxyl group; Subject Term: METHODOLOGY; Subject Term: Derivatization; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 812320 Drycleaning and Laundry Services (except Coin-Operated); NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Turnipseed, Sherri B.
AU - Clark, Susan B.
AU - Karbiwnyk, Christine M.
AU - Andersen, Wendy C.
AU - Miller, Keith E.
AU - Madson, Mark R.
T1 - Analysis of aminoglycoside residues in bovine milk by liquid chromatography electrospray ion trap mass spectrometry after derivatization with phenyl isocyanate
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/05/15/
VL - 877
IS - 14/15
M3 - Article
SP - 1487
EP - 1493
SN - 15700232
AB - Abstract: A derivatization procedure using phenyl isocyanate was adapted to liquid chromatography ion trap mass spectrometry (LC–MS n ) for confirmation and quantification of aminoglycoside residues in milk. Aminoglycoside residues were extracted from milk with acid and isolated from the matrix with a weak cation exchange solid-phase extraction cartridge. After isolating the compounds from the milk, derivatives of gentamicin, neomycin, and tobramycin were formed by reacting the drugs with phenyl isocyanate in the presence of triethylamine. The analytes were separated using a dilute formic acid/acetonitrile gradient on a reversed-phase LC column. The derivatized compounds were analyzed using positive ion electrospray LC–MS n with ion trap detection. Product ion spectra were generated from the derivatized protonated molecules. Specific ion transitions were evaluated for quantitative determination and qualitative confirmation of residues in milk. Using this procedure, residues were qualitatively confirmed in milk samples fortified with gentamicin and neomycin at levels ranging from 15 to 300ngmL−1. Gentamicin has four major components that were successfully separated and confirmed independently; for quantitative determination the peak areas from the four analogs were summed. Tobramycin was added as an internal standard for quantitation to mitigate the effects of matrix ion suppression and variable recoveries. Overall recoveries for this method ranged from 80% to 120% with relative standard deviations of less than 25%. The method detection limits are 9.8ngmL−1 for NEO and 12.8ngmL−1 for total GEN residues. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMINOGLYCOSIDES
KW - BIOMOLECULES -- Analysis
KW - MILK
KW - ISOCYANATES
KW - DERIVATIZATION
KW - MASS spectrometry
KW - LIQUID chromatography
KW - SOLID phase extraction
KW - Aminoglycosides
KW - Derivatization
KW - Liquid chromatography–mass spectrometry
KW - Milk
KW - Phenyl isocyanate
N1 - Accession Number: 38806032; Turnipseed, Sherri B. 1; Email Address: sherri.turnipseed@fda.hhs.gov Clark, Susan B. 2 Karbiwnyk, Christine M. 1 Andersen, Wendy C. 1 Miller, Keith E. 3 Madson, Mark R. 2; Affiliation: 1: Animal Drugs Research Center, Denver Science Branch, US Food and Drug Administration, Denver Federal Center, Denver, CO 80225, USA 2: Denver Science Branch, US Food and Drug Administration, Denver Federal Center, Denver, CO 80225, USA 3: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA; Source Info: May2009, Vol. 877 Issue 14/15, p1487; Subject Term: AMINOGLYCOSIDES; Subject Term: BIOMOLECULES -- Analysis; Subject Term: MILK; Subject Term: ISOCYANATES; Subject Term: DERIVATIZATION; Subject Term: MASS spectrometry; Subject Term: LIQUID chromatography; Subject Term: SOLID phase extraction; Author-Supplied Keyword: Aminoglycosides; Author-Supplied Keyword: Derivatization; Author-Supplied Keyword: Liquid chromatography–mass spectrometry; Author-Supplied Keyword: Milk; Author-Supplied Keyword: Phenyl isocyanate; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jchromb.2009.03.025
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Eun, Jung Woo
AU - Kwack, Seung Jun
AU - Noh, Ji Heon
AU - Jung, Kwang Hwa
AU - Kim, Jeong Kyu
AU - Bae, Hyun Jin
AU - Xie, Hongjian
AU - Ryu, Jae Chun
AU - Ahn, Young Min
AU - Min, Jin-Hye
AU - Park, Won Sang
AU - Lee, Jung Young
AU - Rhee, Gyu Seek
AU - Nam, Suk Woo
T1 - Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/05/15/
VL - 237
IS - 1
M3 - Article
SP - 91
EP - 101
SN - 0041008X
AB - Abstract: The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliative emotional response. MDMA is a potent monoaminergic neurotoxin with the potential to damage brain serotonin and/or dopamine neurons. As the majority of MDMA users are young adults, the risk that users may expose the fetus to MDMA is a concern. However, the majority of studies on MDMA have investigated the effects on adult animals. Here, we investigated whether long-term exposure to MDMA, especially in adolescence, could induce comprehensive transcriptional changes in mouse brain. Transcriptomic analysis of mouse brain regions demonstrated significant gene expression changes in the cerebral cortex. Supervised analysis identified 1028 genes that were chronically dysregulated by long-term exposure to MDMA in adolescent mice. Functional categories most represented by this MDMA characteristic signature are intracellular molecular signaling pathways of neurotoxicity, such as, the MAPK signaling pathway, the Wnt signaling pathway, neuroactive ligand–receptor interaction, long-term potentiation, and the long-term depression signaling pathway. Although these resultant large-scale molecular changes remain to be studied associated with functional brain damage caused by MDMA, our observations delineate the possible neurotoxic effects of MDMA on brain function, and have therapeutic implications concerning neuro-pathological conditions associated with MDMA abuse. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Toxicology
KW - ECSTASY (Drug)
KW - DRUGS -- Side effects
KW - NEUROTOXIC agents
KW - SEROTONIN antagonists
KW - DOPAMINERGIC neurons
KW - MICE as laboratory animals
KW - PHARMACOLOGY
KW - Cerebral cortex
KW - MDMA
KW - Molecular signature
KW - Neurotoxicity
N1 - Accession Number: 39359212; Eun, Jung Woo 1 Kwack, Seung Jun 2 Noh, Ji Heon 1 Jung, Kwang Hwa 1 Kim, Jeong Kyu 1 Bae, Hyun Jin 1 Xie, Hongjian 1 Ryu, Jae Chun 3 Ahn, Young Min 4 Min, Jin-Hye 5 Park, Won Sang 1 Lee, Jung Young 1 Rhee, Gyu Seek 2 Nam, Suk Woo 1; Email Address: swnam@catholic.ac.kr; Affiliation: 1: Department of Pathology, Microdissection Genomics Research Center, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea 2: Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, South Korea 3: Cellular and Molecular Toxicology Lab, Korea Institute of Science and Technology, Seoul 130-650, South Korea 4: Department of Kidney System, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea 5: Department of Anesthesiology and Pain Medicine, Kwandong University College of Medicine, Gangneung, South Korea; Source Info: May2009, Vol. 237 Issue 1, p91; Subject Term: DRUGS -- Toxicology; Subject Term: ECSTASY (Drug); Subject Term: DRUGS -- Side effects; Subject Term: NEUROTOXIC agents; Subject Term: SEROTONIN antagonists; Subject Term: DOPAMINERGIC neurons; Subject Term: MICE as laboratory animals; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: Cerebral cortex; Author-Supplied Keyword: MDMA; Author-Supplied Keyword: Molecular signature; Author-Supplied Keyword: Neurotoxicity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2009.02.027
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Park, Eun-Jung
AU - Cho, Wan-Seob
AU - Jeong, Jayoung
AU - Yi, Jongheop
AU - Choi, Kyunghee
AU - Park, Kwangsik
T1 - Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation
JO - Toxicology
JF - Toxicology
Y1 - 2009/05/17/
VL - 259
IS - 3
M3 - Article
SP - 113
EP - 121
SN - 0300483X
AB - Abstract: The increased application of engineered carbon nanotubes (CNTs) has also raised the level of public concern regarding possible toxicities caused by exposure to these nanostructures. In this study, pulmonary and systemic immune responses induced by intratracheal instillation of multi-walled carbon nanotubes (MWCNTs) were investigated in mice. Total numbers of immune cells in bronchoalveolar lavage (BAL) fluid were significantly increased in treated groups (5, 20, and 50mg/kg doses of MWCNTs) and the distribution of neutrophils was elevated at day 1 after instillation. Pro-inflammatory cytokines (IL-1, TNF-α, IL-6, IL-4, IL-5, IL-10, IL-12, and IFN-γ) were also increased in a dose-dependent manner, both in BAL fluid and in blood. Most of the cytokines showed the highest levels at day 1 after instillation and then decreased. Th2-type cytokines (IL-4, IL-5, and IL-10) were elevated in the treated group to levels higher than those of the Th1-type cytokines (IL-12 and IFN-γ). Furthermore, distributions of B cells in spleen and blood were significantly increased at day 1 after instillation, indicating that Th2-type cytokines had activated B cells, causing them to proliferate. Along with the additional numbers of B cells, granuloma formation in the lung tissue and IgE production were also observed, with an intensity dependent on the dose of MWCNTs instilled. Based on these observations, it is suggested that MWCNTs may induce allergic responses in mice through B cell activation and production of IgE. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLAMMATION -- Immunological aspects
KW - ALLERGY
KW - B cells
KW - CARBON nanotubes
KW - ADMINISTRATION of drugs
KW - TRACHEA
KW - TOXICOLOGY
KW - IMMUNE response
KW - INTUBATION
KW - BRONCHOALVEOLAR lavage
KW - CYTOKINES
KW - IMMUNOGLOBULIN E
KW - B cell activation
KW - Cytokines
KW - IgE
KW - MWCNTs
KW - Pro-inflammation
N1 - Accession Number: 37577269; Park, Eun-Jung 1 Cho, Wan-Seob 2 Jeong, Jayoung 2 Yi, Jongheop 3 Choi, Kyunghee 4 Park, Kwangsik 1; Email Address: kspark@dongduk.ac.kr; Affiliation: 1: College of Pharmacy, Dongduk Women's University, 23-1, Wolgok-dong, Seongbuk-gu, Seoul 136-714, Republic of Korea 2: Division of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea 3: School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Republic of Korea 4: Environmental Research Complex, Kyungseo-dong, Seo-gu, Incheon 404-708, Republic of Korea; Source Info: May2009, Vol. 259 Issue 3, p113; Subject Term: INFLAMMATION -- Immunological aspects; Subject Term: ALLERGY; Subject Term: B cells; Subject Term: CARBON nanotubes; Subject Term: ADMINISTRATION of drugs; Subject Term: TRACHEA; Subject Term: TOXICOLOGY; Subject Term: IMMUNE response; Subject Term: INTUBATION; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: CYTOKINES; Subject Term: IMMUNOGLOBULIN E; Author-Supplied Keyword: B cell activation; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: IgE; Author-Supplied Keyword: MWCNTs; Author-Supplied Keyword: Pro-inflammation; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.tox.2009.02.009
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wolff, Tracy
AU - Shelton, Erica
AU - Sessions, Cecili
AU - Miller, Therese
T1 - Screening for Syphilis Infection in Pregnant Women: Evidence for the U.S. Preventive Services Task Force Reaffirmation Recommendation Statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/05/19/
VL - 150
IS - 10
M3 - Article
SP - 710
EP - W:125
SN - 00034819
AB - Background: In 2004, the U.S. Preventive Services Task Force strongly recommended that clinicians screen all pregnant women for syphilis infection. Purpose: To update the evidence on screening pregnant women for syphilis infection. Data Sources: MEDLINE searches from 1 January 2003 through 31 July 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. Study Selection: English-language studies were selected to answer the following 2 questions: Does screening for syphilis in pregnancy reduce the prevalence of congenital syphilis in neonates? Are there harms of screening for syphilis or harms of treatment with penicillin in pregnancy to women or neonates? Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; and ecologic studies were selected for the potential benefits question. Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; case-control studies; and large case series were selected for the potential harms question. Data Extraction: Information on the study design, selection criteria, demographic characteristics, and clinical outcomes was extracted from each study. Data Synthesis: One study on benefits evaluated the effect before and after the implementation of a universal syphilis screening program for pregnant women and found reductions in rates of congenital syphilis. Two studies on screening accuracy for syphilis reported false-positive rates of less than 1%. One study that used a large insurance claims database reported an incidence of anaphylaxis after oral penicillin of 0.1 per 10 000 dispensings. In a study from Hungary, oral penicillin in pregnancy was not associated with orofacial clefts. Limitations: This was a targeted literature search and could have missed small studies on the benefits and harms of screening for syphilis in pregnancy. We did not review evidence on interventions to improve rates of prenatal screening. Conclusion: New evidence from a study of universal screening supports previous evidence on the effectiveness of screening for syphilis in pregnancy to prevent congenital syphilis. Harms include testing and follow-up for false-positive test results and adverse effects from penicillin treatment. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEXUALLY transmitted diseases
KW - PREGNANCY complications
KW - SYPHILIS
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 40103397; Wolff, Tracy 1 Shelton, Erica 2 Sessions, Cecili 3 Miller, Therese 1; Affiliation: 1: Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 2: Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room WB602, Baltimore, MD 21205-1996 3: Uniformed Services University of the Health Sciences, PMB Department, Room A-1040A, 4301 Jones Bridge Road, Bethesda, MD 20814; Source Info: 5/19/2009, Vol. 150 Issue 10, p710; Subject Term: SEXUALLY transmitted diseases; Subject Term: PREGNANCY complications; Subject Term: SYPHILIS; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105097534
T1 - Screening for syphilis infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement.
AU - Wolff T
AU - Shelton E
AU - Sessions C
AU - Miller T
Y1 - 2009/05/19/
N1 - Accession Number: 105097534. Language: English. Entry Date: 20100924. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 0372351.
KW - Health Screening -- Adverse Effects
KW - Pregnancy Complications, Infectious -- Diagnosis
KW - Pregnancy Complications, Infectious -- Drug Therapy
KW - Syphilis -- Diagnosis
KW - Syphilis -- Drug Therapy
KW - Syphilis, Congenital -- Prevention and Control
KW - Antibiotics -- Adverse Effects
KW - Antibiotics -- Therapeutic Use
KW - Medical Practice, Evidence-Based
KW - False Positive Results
KW - Female
KW - Infant, Newborn
KW - Penicillin G -- Adverse Effects
KW - Penicillin G -- Therapeutic Use
KW - Pregnancy
KW - Risk Assessment
KW - Time Factors
SP - 710
EP - 716
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 150
IS - 10
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: In 2004, the U.S. Preventive Services Task Force strongly recommended that clinicians screen all pregnant women for syphilis infection. PURPOSE: To update the evidence on screening pregnant women for syphilis infection. DATA SOURCES: MEDLINE searches from 1 January 2003 through 31 July 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. STUDY SELECTION: English-language studies were selected to answer the following 2 questions: Does screening for syphilis in pregnancy reduce the prevalence of congenital syphilis in neonates? Are there harms of screening for syphilis or harms of treatment with penicillin in pregnancy to women or neonates? Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; and ecologic studies were selected for the potential benefits question. Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; case-control studies; and large case series were selected for the potential harms question. DATA EXTRACTION: Information on the study design, selection criteria, demographic characteristics, and clinical outcomes was extracted from each study. DATA SYNTHESIS: One study on benefits evaluated the effect before and after the implementation of a universal syphilis screening program for pregnant women and found reductions in rates of congenital syphilis. Two studies on screening accuracy for syphilis reported false-positive rates of less than 1%. One study that used a large insurance claims database reported an incidence of anaphylaxis after oral penicillin of 0.1 per 10,000 dispensings. In a study from Hungary, oral penicillin in pregnancy was not associated with orofacial clefts. LIMITATIONS: This was a targeted literature search and could have missed small studies on the benefits and harms of screening for syphilis in pregnancy. We did not review evidence on interventions to improve rates of prenatal screening. CONCLUSION: New evidence from a study of universal screening supports previous evidence on the effectiveness of screening for syphilis in pregnancy to prevent congenital syphilis. Harms include testing and follow-up for false-positive test results and adverse effects from penicillin treatment.
SN - 0003-4819
AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA.
U2 - PMID: 19451578.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105097534&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vala, M.
AU - Etheridge, S.
AU - Roach, J.A.
AU - Homola, J.
T1 - Long-range surface plasmons for sensitive detection of bacterial analytes
JO - Sensors & Actuators B: Chemical
JF - Sensors & Actuators B: Chemical
Y1 - 2009/05/20/
VL - 139
IS - 1
M3 - Article
SP - 59
EP - 63
SN - 09254005
AB - Abstract: We report a novel prism-coupled surface plasmon resonance (SPR) biosensor based on special surface plasmon (SP) mode referred to as long-range surface plasmon (LRSP). Utilization of LRSP in prism-coupled SPR sensor offers several advantages in comparison with SPR sensors with conventional SPs (cSP) such as extended probe depth of LRSP mode into sensed dielectric and higher sensitivity to the bulk refractive index (RI) changes. The LRSP-supporting multilayer structures and prototype of the sensor setup were prepared. Performance of the LRSP-based sensor was compared to that of the cSP-based sensor in model experiments. LRSP-based sensor was determined to be almost 8 times more sensitive to sample RI changes than the cSP-based sensor. In addition, LRSP-based sensor responses were up to 2.5 and 5.5-fold greater than cSP-based sensor responses for latex beads and the bacterium E. coli HB101P, respectively. [Copyright &y& Elsevier]
AB - Copyright of Sensors & Actuators B: Chemical is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOSENSORS
KW - SURFACE plasmon resonance
KW - MICROBIOLOGICAL chemistry
KW - ESCHERICHIA coli
KW - DIELECTRIC devices
KW - REFRACTIVE index
KW - PERFORMANCE evaluation
KW - Bacterium
KW - Biosensor
KW - Long-range surface plasmon
KW - Surface plasmon resonance
N1 - Accession Number: 39350245; Vala, M. 1 Etheridge, S. 2 Roach, J.A. 2 Homola, J. 1; Email Address: homola@ufe.cz; Affiliation: 1: Institute of Photonics and Electronics ASCR, Chaberská 57, 18251 Prague, Czech Republic 2: US Food and Drug Administration, College Park, USA; Source Info: May2009, Vol. 139 Issue 1, p59; Subject Term: BIOSENSORS; Subject Term: SURFACE plasmon resonance; Subject Term: MICROBIOLOGICAL chemistry; Subject Term: ESCHERICHIA coli; Subject Term: DIELECTRIC devices; Subject Term: REFRACTIVE index; Subject Term: PERFORMANCE evaluation; Author-Supplied Keyword: Bacterium; Author-Supplied Keyword: Biosensor; Author-Supplied Keyword: Long-range surface plasmon; Author-Supplied Keyword: Surface plasmon resonance; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.snb.2008.08.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 120353157
T1 - Trastuzumab cardiotoxicity: FDA review of four adjuvant breast cancer clinical trials leading to trastuzumab marketing approvals.
AU - Fedenko, K
AU - Cortazar, P
AU - Keegan, P
AU - Pazdur, R
Y1 - 2009/05/21/5/21/2009 Supplement Part 1 of 2
N1 - Accession Number: 120353157. Language: English. Entry Date: In Process. Revision Date: 20161223. Publication Type: journal article. Supplement Title: 5/21/2009 Supplement Part 1 of 2. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
SP - e11520
EP - e11520
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 27
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - e11520 Background: Trastuzumab can result in sub-clinical and clinical cardiac failure manifesting as congestive heart failure (CHF), and decreased left ventricular ejection fraction (LVEF).Methods: Data was reviewed from 9837 patients in four randomized trials (NCCTG 9831, NSABP B-31, HERA, and BCIRG-06) that supported trastuzumab HER2 overexpressing adjuvant breast cancer approval.Results: Trastuzumab can cause left ventricular cardiac dysfunction, arrhythmias, hypertension, disabling cardiac failure, cardiomyopathy, and cardiac death. Herceptin can also cause asymptomatic decline in LVEF. There is a 4-6 fold increase in the incidence of symptomatic myocardial dysfunction among patients receiving trastuzumab as a single agent or in combination therapy compared with those not receiving trastuzumab. The highest absolute incidence occurs when trastuzumab is administered with an anthracycline. Clinical trials NCCTG 9831, NSABP B-31, and BCIRG-06 included arms with doxorubicin- cyclophosphamide (AC) followed by a taxane plus trastuzumab. Among 32 patients receiving adjuvant chemotherapy from studies NCCTG 9831 and NSABP B-31 who developed CHF, one patient died of cardiomyopathy and all other patients were receiving cardiac medication at last follow-up. Approximately half of the patients recovered to a normal LVEF (defined as ≥ 50%) on continuing medical management at the time of last follow-up. In BCIRG-06 the incidence of CHF was six (6) fold higher in the AC followed by docetaxel plus trastuzumab arm as compared to AC followed by docetaxel. There was a lower incidence of CHF in the non-anthracycline TCH (docetaxel, carboplatin and trastuzumab) arm in BCIRG-06 comparable to trastuzumab monotherapy.Conclusions: Cardiotoxicity manifesting as sub-clinical and clinical cardiac failure is a known side effect of trastuzumab. In an era where trastuzumab is given earlier in the treatment of breast cancer (adjuvant setting), the safety of continuation or resumption of trastuzumab in patients with trastuzumab-induced left ventricular cardiac dysfunction has not been studied. No significant financial relationships to disclose.
SN - 0732-183X
AD - Food and Drug Administration, Silver Spring, MD
U2 - PMID: 27964620.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 120349455
T1 - Pain and analgesic use in men with metastatic prostate cancer.
AU - Basch, E M
AU - Sit, L
AU - Fruscione, M
AU - Burke, L
AU - Kane, R
AU - George, D
AU - Carducci, M A
AU - Matthew, P
AU - Beer, T M
AU - Scher, H I
Y1 - 2009/05/21/5/21/2009 Supplement Part 1 of 2
N1 - Accession Number: 120349455. Language: English. Entry Date: In Process. Revision Date: 20161223. Publication Type: journal article. Supplement Title: 5/21/2009 Supplement Part 1 of 2. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
SP - e20515
EP - e20515
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 27
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - e20515 Background: Pain is an important endpoint in metastatic prostate cancer and was the basis for the 1996 FDA approval of mitoxantrone. Standards for pain assessment have evolved, and a 2006 draft FDA guidance provides new recommendations for patient- reported outcomes. Contemporary palliation models generally require pain reduction starting from baseline worst pain scores of ≥4/10, and progression models require a sufficient proportion of patients' pain scores to worsen in order to assure an adequate effect size. The prevalence and distribution of pain severity at specific points in the prostate cancer disease continuum are not well defined. Consequently, it is unclear if sufficient numbers of patients are available to conduct prospective studies using pain palliation or prevention as primary endpoints.Methods: A questionnaire that includes the Brief Pain Inventory and additional pain/analgesia items was developed as a collaboration between the DOD/PCF-supported Prostate Cancer Clinical Trials Consortium (PCCTC) and FDA Study Endpoints and Labeling Design (SEALD) team. IRB waivers were obtained for anonymous administration at 5 PCCTC institutions (Sloan-Kettering, Duke, Johns Hopkins, Anderson, OHSU). Administration is ongoing.Results: Between August-December 2008, 325 men with prostate cancers representing different disease states being seen in outpatient clinics of participating centers were each queried once. Median age was 70 (range 49-87). More than half (n=175) self-reported metastatic disease, including 129 with bone metastases. Among those with bone metastases, 76 (59%) reported experiencing any level of pain in the last week; 49 (38%) reported a worst pain score ≥4/10 of which 38 (78%) used analgesics over the past week and 31 (63%) used daily analgesia. In addition, 70 of the 76 (92%) noted that their pain interfered with work, sleep, or enjoyment of life, with 25 (33%) noting severe interference. Among the 49 patients with pain scores ≥4/10, current or past docetaxel use was reported by 32 (65%), androgen deprivation therapy by 47 (96%), and 28 (57%) had been or were currently enrolled in a clinical trial.Conclusions: Pain is sufficiently prevalent in men with metastatic prostate cancer to enable prospective assessment of palliation endpoints in clinical trials. No significant financial relationships to disclose.
SN - 0732-183X
AD - Memorial Sloan-Kettering Cancer Center, New York, NY; Food and Drug Administration, Silver Spring,; Duke Comprehensive Cancer Center, Durham, NC; Johns Hopkins, Baltimore,; M. D. Anderson Cancer Center, Houston, TX; OHSU Cancer Institute, Portland, OR
U2 - PMID: 27960916.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 120349508
T1 - Functional recovery after surgery in patients with breast cancer.
AU - Springer, B
AU - Danoff, J
AU - Levy, E
AU - Stout, N
AU - Pfalzer, L
AU - McGarvey, C
AU - Gerber, L
AU - Soballe, P
Y1 - 2009/05/21/5/21/2009 Supplement Part 1 of 2
N1 - Accession Number: 120349508. Language: English. Entry Date: In Process. Revision Date: 20161223. Publication Type: journal article. Supplement Title: 5/21/2009 Supplement Part 1 of 2. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 8309333.
SP - e20539
EP - e20539
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
JA - J CLIN ONCOL
VL - 27
CY - Alexandria, Virginia
PB - American Society of Clinical Oncology
AB - e20539 Background: Upper extremity dysfunction and decreased quality of life are frequently reported sequelae of the treatment for early stage breast cancer (BC). Surgical trauma and/or radiation therapy may lead to upper extremity (UE) impairments, functional limitations and disabilities including pain, stiffness, lymphedema, decreased strength and range of motion (ROM) and decreased activity tolerance. In this study we examined specific functional characteristics of shoulder impairments and associated limitations.Methods: Women (n=88, mean age = 53y [SD=11.81]) newly diagnosed with unilateral, Stage I to III BC were screened pre-operatively for this prospective trial. Patient data and physical therapy based assessments were recorded at the pre-operative visit (baseline) and at 1, 3, and 12+ months (BA, M1, M3, M12) after surgical treatment including pain (VAS on 10 point scale), bilateral shoulder ROM and strength (MMT). Volumes for upper extremities were taken using an optoelectric device (Perometer®). During post BC treatment visits, appropriate physical therapy was provided, and if there was a diagnosis of lymphedema, a light-grade compression garment was fitted. ROMs (shoulder Abd, ER, Flex, IR), a composite MMT value, and volume were analyzed with one-way repeated ANOVA including Greenhouse-Geisser correction for non-normal data where necessary. Post hoc testing was done using Within-Subjects Contrasts. Limited range of values for pain resulted in a highly skewed distribution, inappropriate for statistical testing.Results: For the variables Abd, ER, Flex, and sumMMT there was a decrease in function from BA to M1, improvement from M1 to M3, and further improvement from M3 to M12 (all p < 0.0001). For IR there was a decrease from BA to M1, no difference between M1 and M3, and an improvement from M1 and M3 to M12 (p < 0.3). Pain remained relatively low with 60-80% of the women reporting ≤2/10.Conclusions: After surgery for breast cancer, a decrement in shoulder function may be expected around 1 month after the procedure. Most subjects demonstrated significant improvement in function by 3 months after the procedure, and by 12 months, subjects achieved near complete recovery of shoulder impairment. No significant financial relationships to disclose.
SN - 0732-183X
AD - Office of The Surgeon General, Falls Church, VA; National Institutes of Health, Bethesda,; National Naval Medical Center, Bethesda,; University of Michigan, Bethesda,; CLM Consulting Services LLC, Rockville,; George Mason University, Fairfax, VA; Uniformed Services University, Bethesda
U2 - PMID: 27960969.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Rahman, M.F.
AU - Wang, J.
AU - Patterson, T.A.
AU - Saini, U.T.
AU - Robinson, B.L.
AU - Newport, G.D.
AU - Murdock, R.C.
AU - Schlager, J.J.
AU - Hussain, S.M.
AU - Ali, S.F.
T1 - Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/05/22/
VL - 187
IS - 1
M3 - Article
SP - 15
EP - 21
SN - 03784274
AB - Abstract: Nanoparticles are small scale substances (<100nm) used in biomedical applications, electronics, and energy production. Increased exposure to nanoparticles being produced in large-scale industry facilities elicits concerns for the toxicity of certain classes of nanoparticles. This study evaluated the effects of silver-25nm (Ag-25) nanoparticles on gene expression in different regions of the mouse brain. Adult-male C57BL/6N mice were administered (i.p.) 100mg/kg, 500mg/kg or 1000mg/kg Ag-25 and sacrificed after 24h. Regions from the brain were rapidly removed and dissected into caudate nucleus, frontal cortex and hippocampus. Total RNA was isolated from each of the three brain regions collected and real-time RT-PCR analysis was performed using Mouse Oxidative Stress and Antioxidant Defense Arrays. Array data revealed the expression of genes varied in the caudate nucleus, frontal cortex and hippocampus of mice when treated with Ag-25. The data suggest that Ag-25 nanoparticles may produce neurotoxicity by generating free radical-induced oxidative stress and by altering gene expression, producing apoptosis and neurotoxicity. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Electric power production
KW - Gene expression
KW - Oxidative stress
KW - Nanoparticles
KW - Mice as laboratory animals
KW - Neurotoxicology
KW - Neurodegeneration
KW - Free radicals (Chemistry)
KW - Arrays
KW - Free radicals
KW - Neurotoxicity
KW - Reactive oxygen species
KW - Silver-25 nanoparticles
N1 - Accession Number: 36971170; Rahman, M.F. 1; Wang, J. 1; Patterson, T.A. 1; Saini, U.T. 1; Robinson, B.L. 2; Newport, G.D. 1; Murdock, R.C. 3; Schlager, J.J. 3; Hussain, S.M. 3; Email Address: Saber.Hussain@wpafb.af.mil; Ali, S.F. 1; Email Address: Syed.Ali@fda.hhs.gov; Affiliations: 1: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA; 2: Toxicologic Pathology Associates, 3900 NCTR Road, Jefferson, AR 72079-9502, USA; 3: Applied Biotechnology Branch, Human Effectiveness Directorate, AFRL/HEPB, Area B, R Street, Building 837, Wright-Patterson AFB, Dayton, OH 45433-5707, USA; Issue Info: May2009, Vol. 187 Issue 1, p15; Thesaurus Term: Electric power production; Subject Term: Gene expression; Subject Term: Oxidative stress; Subject Term: Nanoparticles; Subject Term: Mice as laboratory animals; Subject Term: Neurotoxicology; Subject Term: Neurodegeneration; Subject Term: Free radicals (Chemistry); Author-Supplied Keyword: Arrays; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Neurotoxicity; Author-Supplied Keyword: Reactive oxygen species; Author-Supplied Keyword: Silver-25 nanoparticles; NAICS/Industry Codes: 221112 Fossil Fuel Electric Power Generation; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxlet.2009.01.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=36971170&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kulka, Michael
AU - Calvo, Mona S.
AU - Ngo, Diana T.
AU - Wales, Samantha Q.
AU - Goswami, Biswendu B.
T1 - Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression
JO - Virology
JF - Virology
Y1 - 2009/05/25/
VL - 388
IS - 1
M3 - Article
SP - 169
EP - 184
SN - 00426822
AB - Abstract: The latent, constitutively expressed protein RNase L is activated in coxsackievirus and HAV strain 18f infected FRhK-4 cells. Endogenous oligoadenylate synthetase (OAS) from uninfected and virus infected cell extracts synthesizes active forms of the triphosphorylated 2-5A oligomer (the only known activator of RNase L) in vitro and endogenous 2-5A is detected in infected cell extracts. However, only the largest OAS isoform, OAS3, is readily detected throughout the time course of infection. While IFNβ treatment results in an increase in the level of all three OAS isoforms in FRhK-4 cells, IFNβ pretreatment does not affect the temporal onset or enhancement of RNase L activity nor inhibit virus replication. Our results indicate that CVB1 and HAV/18f activate the 2-5OAS/RNase L pathway in FRhK-4 cells during permissive infection through endogenous levels of OAS, but contrary to that reported for some picornaviruses, CVB1 and HAV/18f replication is insensitive to this activated antiviral pathway. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OLIGOADENYLATES
KW - PROTEIN kinases
KW - RHESUS monkey
KW - COXSACKIEVIRUS diseases
KW - GENE expression
KW - HEPATITIS A virus
KW - VIRAL genetics
KW - ANTIVIRAL agents
KW - 2-5A
KW - Antiviral
KW - Coxsackievirus
KW - Hepatitis A virus
KW - Oligoadenylate synthetase
KW - RNase L
N1 - Accession Number: 38799950; Kulka, Michael 1; Email Address: michael.kulka@fda.hhs.gov Calvo, Mona S. 2; Email Address: mona.calvo@fda.hhs.gov Ngo, Diana T. 1; Email Address: diana.ngo@fda.hhs.gov Wales, Samantha Q. 1; Email Address: samantha.wales@fda.hhs.gov Goswami, Biswendu B. 1; Email Address: biswendu.goswami@fda.hhs.gov; Affiliation: 1: Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA 2: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA; Source Info: May2009, Vol. 388 Issue 1, p169; Subject Term: OLIGOADENYLATES; Subject Term: PROTEIN kinases; Subject Term: RHESUS monkey; Subject Term: COXSACKIEVIRUS diseases; Subject Term: GENE expression; Subject Term: HEPATITIS A virus; Subject Term: VIRAL genetics; Subject Term: ANTIVIRAL agents; Author-Supplied Keyword: 2-5A; Author-Supplied Keyword: Antiviral; Author-Supplied Keyword: Coxsackievirus; Author-Supplied Keyword: Hepatitis A virus; Author-Supplied Keyword: Oligoadenylate synthetase; Author-Supplied Keyword: RNase L; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 16p; Document Type: Article
L3 - 10.1016/j.virol.2009.03.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38799950&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Vugia, D.
AU - Cronquist, A.
AU - Cartter, M.
AU - Tobin-D'Angelo, M.
AU - Blythe, D.
AU - Smith, K.
AU - Lathrop, S.
AU - Morse, D.
AU - Cieslak, P.
AU - Dunn, J.
AU - Holt, K. G.
AU - Henao, O. L.
AU - Hoekstra, R. M.
AU - Angulo, F. J.
AU - Griffin, P. M.
AU - Tauxe, R. V.
AU - Trivedi, K.
T1 - Preliminary FoodNet Data on the Incidence of Infection With Pathogens Transmitted Commonly Through Food--10 States, 2008.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/05/27/
VL - 301
IS - 20
M3 - Article
SP - 2088
EP - 2090
SN - 00987484
AB - The article discusses a report providing detailed information on the Foodborne Disease Active Surveillance Network (FoodNet) as part of the U.S. Centers of Disease Control and Prevention's Emerging Infections Program. The program collects data from 10 U.S. states on diseases caused by enteric pathogens transmitted through food. Surveillance data from 2008 found that the estimated incidence of infections caused by Cyclospora, Listeria, Salmonella, Shigella, and several others did not change significantly when compared with the preceding 3 years.
KW - NUTRITIONALLY induced diseases
KW - FOOD poisoning
KW - COMPUTER network resources
KW - FOOD contamination -- Research
KW - PATHOGENIC microorganisms
KW - SALMONELLA
KW - PATHOGENIC bacteria
KW - UNITED States
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 40211628; Vugia, D. 1 Cronquist, A. 2 Cartter, M. 3 Tobin-D'Angelo, M. 4 Blythe, D. 5 Smith, K. 6 Lathrop, S. 7 Morse, D. 8 Cieslak, P. 9 Dunn, J. 10 Holt, K. G. 11 Henao, O. L. 12 Hoekstra, R. M. 12 Angulo, F. J. 12 Griffin, P. M. 12 Tauxe, R. V. 12 Trivedi, K. 13; Affiliation: 1: California Dept of Public Health 2: Colorado Dept of Public Health and Environment. 3: Connecticut Dept of Public Health. 4: Div of Public Health, Georgia Dept of Human Resources. 5: Maryland Dept of Health and Mental Hygiene. 6: Minnesota Dept of Health 7: New Mexico Dept of Health. 8: New York State Dept of Health. 9: Oregon Public Health Div 10: Tennessee Dept of Health 11: Food Safety and Inspection Svc, US Dept of Agriculture. Center for Food Safety and Applied Nutrition, Food and Drug Admin. 12: Div of Food- borne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases 13: EIS Officer, CDC; Source Info: 5/27/2009, Vol. 301 Issue 20, p2088; Subject Term: NUTRITIONALLY induced diseases; Subject Term: FOOD poisoning; Subject Term: COMPUTER network resources; Subject Term: FOOD contamination -- Research; Subject Term: PATHOGENIC microorganisms; Subject Term: SALMONELLA; Subject Term: PATHOGENIC bacteria; Subject Term: UNITED States; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105354821
T1 - Evaluation of the filtration performance of 21 N95 filtering face piece respirators after prolonged storage.
AU - Viscusi DJ
AU - Bergman M
AU - Sinkule E
AU - Shaffer RE
Y1 - 2009/06//
N1 - Accession Number: 105354821. Language: English. Entry Date: 20090828. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Equipment Maintenance
KW - Respiratory Protective Devices
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Nonexperimental Studies
KW - Human
SP - 381
EP - 386
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 37
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: Organizations are stockpiling respirators to prepare for an influenza pandemic. To understand better the effects of prolonged storage, this investigation evaluated the filtration efficiency of 21 different models of National Institute for Occupational Safety and Health (NIOSH)-certified disposable N95 filtering face piece respirators. These respirators had been stored in their original packaging for a period of at least 6 years in research laboratories and dry warehouse facilities, ranging in temperature between 15 degrees C and 32 degrees C and relative humidity between 20% and 80%. METHODS: Filter penetration was measured using an abbreviated version of the NIOSH respirator certification test incorporating a polydisperse sodium chloride aerosol at 85 L/min. RESULTS: Of the 21 respirator models tested, 19 models had both average penetration results of less than 5%. Mean initial penetration values ranged from 0.39% to 5.83%, whereas mean maximum penetration values ranged from 0.95% to 5.83%. There did not appear to be any correlation between the length of storage and failure to pass the filtration test. CONCLUSION: Results indicate that most N95 filtering face piece respirators stored for up to 10 years at warehouse conditions will likely have expected levels of filtration performance and that the degree of filtration efficiency degradation is likely model specific.
SN - 0196-6553
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health/CDC, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA.
U2 - PMID: 19188003.
DO - 10.1016/j.ajic.2008.09.021
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105352678
T1 - AHRQ commentary. Reducing central line-related bloodstream infections.
AU - Clancy CM
Y1 - 2009/06//
N1 - Accession Number: 105352678. Language: English. Entry Date: 20090821. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Critical Care; Perioperative Care. NLM UID: 0372403.
KW - Bacteremia -- Prevention and Control
KW - Catheter-Related Infections -- Prevention and Control
KW - Catheterization, Central Venous -- Adverse Effects
KW - Checklists -- Utilization
KW - Intensive Care Units
KW - Academic Medical Centers -- Maryland
KW - Bacteremia -- Epidemiology -- Maryland
KW - Catheter-Related Infections -- Epidemiology -- Maryland
KW - Critical Care Nursing
KW - Maryland
KW - Organizational Change
KW - Organizational Culture
KW - Physicians
KW - Professional Compliance
KW - Program Implementation
SP - 1123
EP - 1125
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 89
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality, Rockville, MD.
U2 - PMID: 19500702.
DO - 10.1016/j.aorn.2009.05.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105352678&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - González-Escalona, Narjol
AU - Hammack, Thomas S.
AU - Russell, Mindi
AU - Jacobson, Andrew P.
AU - De Jesús, Antonio J.
AU - Brown, Eric W.
AU - Lampel, Keith A.
T1 - Detection of Live Salmonella sp. Cells in Produce by a TaqMan-Based Quantitative Reverse Transcriptase Real-Time PCR Targeting invA mRNA.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/06//
VL - 75
IS - 11
M3 - Article
SP - 3714
EP - 3720
SN - 00992240
AB - Salmonella enterica contamination in foods is a significant concern for public health. When DNA detection methods are used for analysis of foods, one of the major concerns is false-positive results from the detection of dead cells. To circumvent this crucial issue, a TaqMan quantitative real-time RT-PCR (qRT-PCR) assay with an RNA internal control was developed. invA RNA standards were used to determine the detection limit of this assay as well as to determine invA mRNA levels in mid-exponential-, late-exponential-, and stationary-phase cells. This assay has a detection limit of 40 copies of invA mRNA per reaction. The levels of invA mRNA in mid-exponential-, late-exponential-, and stationary-phase S. enterica cells was approximately 1 copy per 3 CFU, 1 copy per CFU, and 4 copies per 103 CFU, respectively. Spinach, tomatoes, jalapeno peppers, and serrano peppers were artificially contaminated with four different Salmonella serovars at levels of 105 and less than 10 CFU. These foods were analyzed with qRT-PCR and with the FDA's Bacteriological Analytical Manual Salmonella culture method (W. A. Andrews and T. S. Hammack, in G. J. Jackson et al., ed., Bacteriological analytical manual online, http://www.cfsan.fda.gov/∼ebam/bam-5.html, 2007). Comparable results were obtained by both methods. Only live Salmonella cells could be detected by this qRT-PCR assay, thus avoiding the dangers of false-positive results from nonviable cells. False negatives (inhibition of the PCR) were also ruled out through the use of an RNA internal control. This assay allows for the fast and accurate detection of viable Salmonella spp. in spinach, tomatoes, and in both jalapeno and serrano peppers. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA enteritidis
KW - PUBLIC health
KW - DNA polymerases
KW - FOOD -- Analysis
KW - RNA
KW - MESSENGER RNA
KW - SPINACH
KW - JALAPENO
KW - PEPPERS
N1 - Accession Number: 41891770; González-Escalona, Narjol 1; Email Address: narjol.gonzalez-escalona@fda.hhs.gov Hammack, Thomas S. 1 Russell, Mindi Jacobson, Andrew P. 1 De Jesús, Antonio J. 1 Brown, Eric W. Lampel, Keith A. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland; Source Info: Jun2009, Vol. 75 Issue 11, p3714; Subject Term: SALMONELLA enteritidis; Subject Term: PUBLIC health; Subject Term: DNA polymerases; Subject Term: FOOD -- Analysis; Subject Term: RNA; Subject Term: MESSENGER RNA; Subject Term: SPINACH; Subject Term: JALAPENO; Subject Term: PEPPERS; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.02686-08
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41891770&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Marcarelli, Michael E.
AU - Helfgott, Jonathan S.
T1 - Medical Device Compliance.
JO - Applied Clinical Trials
JF - Applied Clinical Trials
Y1 - 2009/06//
VL - 18
IS - 6
M3 - Article
SP - 52
EP - 56
PB - Advanstar Communications Inc.
SN - 10648542
AB - The article focuses on the Probability Sampling Study (PSS) that aims to evaluate the regulatory compliance for medical device clinical investigations of the Food and Drug Administration (FDA) in the U.S. The results of the PSS are use to channel the limited FDA resources into several areas of concern. The data from the PSS may be used to support the need for a higher level of attention to sponsor monitoring and investigator training.
KW - PROBABILITY theory
KW - SAMPLING (Statistics)
KW - CLINICAL trials
KW - MEDICAL research personnel
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 41894607; Marcarelli, Michael E. 1; Email Address: michael.marcarelli@fda.hhs.gov Helfgott, Jonathan S. 2; Affiliation: 1: Director, Division of Bioresearch Monitoring, Office of Compliance, Center for Devices and Radiological Health, FDA 2: Consumer Safety Officer, Division of Bioresearch Monitoring, Office of Compliance, Center for Devices and Radiological Health, FDA; Source Info: Jun2009, Vol. 18 Issue 6, p52; Subject Term: PROBABILITY theory; Subject Term: SAMPLING (Statistics); Subject Term: CLINICAL trials; Subject Term: MEDICAL research personnel; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hyun-Ju Moon
AU - Ji Hyun Seok
AU - Soon Sun Kim
AU - Gyu Seek Rhee
AU - Rhee Da Lee
AU - Jun Young Yang
AU - Soo Yeong Chae
AU - Seung Hee Kim
AU - Ji Young Kim
AU - Jin-Yong Chung
AU - Jong-Min Kim
AU - Soo Youn Chung
T1 - Lactational coumestrol exposure increases ovarian apoptosis in adult rats.
JO - Archives of Toxicology
JF - Archives of Toxicology
Y1 - 2009/06//
VL - 83
IS - 6
M3 - Article
SP - 601
EP - 608
SN - 03405761
AB - This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, and 10 mg/kg COU during the lactation period and the reproductive effects of female pups were investigated in young adults. Rats were sacrificed at postnatal days (PND) 81–84. Ovarian weights were reduced significantly at 0.1 and 1.0 mg/kg COU. The reduction in the ovarian weight occurred in parallel with an increase in the apoptosis at PND 135–140. A marked dose-dependent increase in the expressions of active caspase-3 and -7 was observed in ovarian granulosa cells. Immunostaining for active caspase-3 and the TUNEL staining of apoptotic cells were also increased in ovaries exposed to COU in a dose-dependent manner. These results suggest new sights into the effect of lactational exposure to COU on the female reproductive health. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVARIES
KW - APOPTOSIS
KW - RATS
KW - COUMESTROL
KW - LACTATION
KW - BREAST milk
KW - PHYTOESTROGENS
KW - BREASTFEEDING (Humans)
KW - ESTROGEN
KW - Caspase-3
KW - Coumestrol
KW - Lactational exposure
KW - Ovarian apoptosis
N1 - Accession Number: 41429113; Hyun-Ju Moon 1; Email Address: mhj1612@kfda.go.kr Ji Hyun Seok 1 Soon Sun Kim 1 Gyu Seek Rhee 1 Rhee Da Lee 1 Jun Young Yang 1 Soo Yeong Chae 1 Seung Hee Kim 1 Ji Young Kim 2 Jin-Yong Chung 2 Jong-Min Kim 2 Soo Youn Chung 1; Affiliation: 1: Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, South Korea. 2: College of Medicine, Dong-A University, Busan 602-103, South Korea.; Source Info: Jun2009, Vol. 83 Issue 6, p601; Subject Term: OVARIES; Subject Term: APOPTOSIS; Subject Term: RATS; Subject Term: COUMESTROL; Subject Term: LACTATION; Subject Term: BREAST milk; Subject Term: PHYTOESTROGENS; Subject Term: BREASTFEEDING (Humans); Subject Term: ESTROGEN; Author-Supplied Keyword: Caspase-3; Author-Supplied Keyword: Coumestrol; Author-Supplied Keyword: Lactational exposure; Author-Supplied Keyword: Ovarian apoptosis; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Color Photograph, 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1007/s00204-008-0400-0
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41429113&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Mitchell, JR;
AU - Scardina, KM;
T1 - HRSA's updates and new patient safety collaborative
CT - HRSA's updates and new patient safety collaborative
JO - ASHP Summer Meeting
JF - ASHP Summer Meeting
VL - 65
IS - Jun
AD - HRSA, Healthcare Syst Bur, 5600 Fishers Lane, Room 10C-03, Parklawn Bldg, Rockville, MD 20857, USA jmitchell@hrsa.gov
N1 - Accession Number: 46-08013; Language: English; Publication Type: Abstract of Meeting Presentation; Section Heading: Institutional Pharmacy Practice; Sociology, Economics and EthicsPharmaceutical Education
N2 - The HRSA PSPC is a national effort to improve patient safety, increase cost-effective clinical pharmacy services, and improve health outcomes in the safety-net population. At the end of the study phase, a Change Package of leading practices in these areas will be vetted through an expert panel. Teams throughout the country will enroll in the PSPC and will present the results of testing action items to improve patient safety, clinical pharmacy services and health outcomes. The goals are to share with the profession the rapid results being achieved through being enrolled in the PSPC and how the Improvement Model for a Collaborative is conducted. An additional goal is to share HRSA's vision and expectations of this model and the continued success of this bold, national effort and its effect on the profession of pharmacy and the safety and quality of care we provide in the safety net.
KW - ASHP meeting abstracts--Clinical pharmacy;
KW - Clinical pharmacy--services;
KW - Economics--cost benefit analysis;
KW - Outcomes--economics;
KW - Pharmacy services--clinical;
KW - Pharmacy, institutional, hospital--services;
KW - Patient care--Clinical pharmacy;
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ipa&AN=46-08013&site=ehost-live&scope=site
DP - EBSCOhost
DB - ipa
ER -
TY - JOUR
AU - Sheng-Fowler, Li
AU - Lewis, Andrew M.
AU - Peden, Keith
T1 - Issues associated with residual cell-substrate DNA in viral vaccines
JO - Biologicals
JF - Biologicals
Y1 - 2009/06//
VL - 37
IS - 3
M3 - Article
SP - 190
EP - 195
SN - 10451056
AB - Abstract: The presence of some residual cellular DNA derived from the production-cell substrate in viral vaccines is inevitable. Whether this DNA represents a safety concern, particularly if the cell substrate is derived from a tumor or is tumorigenic, is unknown. DNA has two biological activities that need to be considered. First, DNA can be oncogenic; second, DNA can be infectious. As part of our studies to assess the risk of residual cell-substrate DNA in viral vaccines, we have established assays that can quantify the biological activities of DNA. From data obtained using these assays, we have estimated the risk of an oncogenic or an infectious event from DNA. Because these estimates were derived from the most sensitive assays identified so far, they likely represent worst-case estimates. In addition, methods that inactivate the biological activities of DNA can be assessed and estimations of risk reduction by these treatments can be made. In this paper, we discuss our approaches to address potential safety issues associated with residual cellular DNA from neoplastic cell substrates in viral vaccines, summarize the development of assays to quantify the oncogenic and infectivity activities of DNA, and discuss methods to reduce the biological activities of DNA. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEIC acids
KW - BIOMOLECULES
KW - GENETIC transformation
KW - NUCLEOTIDES
KW - IMMOBILIZED nucleic acids
KW - Infectious DNA
KW - Oncogenic DNA
KW - Risk evaluation
N1 - Accession Number: 40120778; Sheng-Fowler, Li 1 Lewis, Andrew M. 1 Peden, Keith; Email Address: keith.peden@fda.hhs.gov; Affiliation: 1: Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research,Food and Drugs Administration, Bethesda, MD 20892, USA; Source Info: Jun2009, Vol. 37 Issue 3, p190; Subject Term: NUCLEIC acids; Subject Term: BIOMOLECULES; Subject Term: GENETIC transformation; Subject Term: NUCLEOTIDES; Subject Term: IMMOBILIZED nucleic acids; Author-Supplied Keyword: Infectious DNA; Author-Supplied Keyword: Oncogenic DNA; Author-Supplied Keyword: Risk evaluation; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.02.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40120778&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Khan, Arifa S.
AU - Ma, Wenbin
AU - Ma, Yunkun
AU - Kumar, Anita
AU - Williams, Dhanya K.
AU - Muller, Jacqueline
AU - Ma, Hailun
AU - Galvin, Teresa A.
T1 - Proposed algorithm to investigate latent and occult viruses in vaccine cell substrates by chemical induction
JO - Biologicals
JF - Biologicals
Y1 - 2009/06//
VL - 37
IS - 3
M3 - Article
SP - 196
EP - 201
SN - 10451056
AB - Abstract: The recent urgency to develop new vaccines for emerging and re-emerging diseases, such as pandemic influenza, has necessitated the use of cell substrates not previously used in the manufacture of licensed vaccines. A major safety concern in the use of novel cell substrates is the presence of potential adventitious agents, such as latent and occult viruses, that may not be detected by currently used conventional assays. In cases where the novel cell substrate is known to be tumorigenic, there are additional safety issues related to tumorigenicity of intact cells and oncogenicity of residual cellular DNA. We have developed a strategy for evaluating vaccine cell substrates for the presence of latent/occult viruses, including endogenous retroviruses, latent RNA viruses and oncogenic DNA viruses, by optimizing conditions for chemical induction of viruses and using a combination of broad and specific assays to enable detection of known and novel viruses. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PREVENTIVE medicine
KW - MEDICINE
KW - MEDICAL care
KW - IMMUNIZATION
KW - NEEDLE exchange programs
KW - Chemical inducers
KW - Latent viruses
KW - Vaccine cell substrates
KW - Virus activation
N1 - Accession Number: 40120779; Khan, Arifa S. 1; Email Address: arifa.khan@fda.hhs.gov Ma, Wenbin 1 Ma, Yunkun 1 Kumar, Anita 1 Williams, Dhanya K. 1 Muller, Jacqueline 2 Ma, Hailun 1 Galvin, Teresa A. 1; Affiliation: 1: Laboratory of Retrovirus Research, Center for Biologics, Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike HFM-454, Building 29B, Room 4NN10, Bethesda, MD 20892, USA 2: Division of Viral Products, Center for Biologics, Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Jun2009, Vol. 37 Issue 3, p196; Subject Term: PREVENTIVE medicine; Subject Term: MEDICINE; Subject Term: MEDICAL care; Subject Term: IMMUNIZATION; Subject Term: NEEDLE exchange programs; Author-Supplied Keyword: Chemical inducers; Author-Supplied Keyword: Latent viruses; Author-Supplied Keyword: Vaccine cell substrates; Author-Supplied Keyword: Virus activation; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.02.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40120779&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
ID - 105533778
T1 - Recombinant activated protein C and risk of bleeding...Crit Care Med. 2009 Jan;37(1):19-25
AU - Lorenz BD
AU - Smith TD
AU - Laessig K
AU - Chambers W
AU - Nambiar S
AU - Lorenz, Benjamin D
AU - Smith, Thomas D
AU - Laessig, Katherine
AU - Chambers, Wiley
AU - Nambiar, Sumati
Y1 - 2009/06//
N1 - Accession Number: 105533778. Language: English. Entry Date: 20090619. Revision Date: 20161129. Publication Type: letter; commentary; letter. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 0355501.
KW - Blood Proteins -- Adverse Effects
KW - Hemorrhage -- Chemically Induced
KW - Recombinant Proteins -- Adverse Effects
KW - Risk Factors
SP - 2141
EP - 2142
JO - Critical Care Medicine
JF - Critical Care Medicine
JA - CRIT CARE MED
VL - 37
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0090-3493
AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD.
U2 - PMID: 19448483.
DO - 10.1097/CCM.0b013e3181a5c415
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105533778&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Seong-Jae
AU - Kweon, Ohgew
AU - Cerniglia, Carl E
T1 - Proteomic applications to elucidate bacterial aromatic hydrocarbon metabolic pathways
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
Y1 - 2009/06//
VL - 12
IS - 3
M3 - Article
SP - 301
EP - 309
SN - 13695274
AB - The growing availability of genome sequences and advancement of high-throughput omics and analytical chemistry technologies have reinvigorated the study of biodegradation processes in aromatic hydrocarbon catabolism. In particular, proteomics approaches globally have identified and quantified bacterial enzymes responsible for aromatic hydrocarbon metabolism, which significantly assists in determining strategies for the biodegradation of aromatic hydrocarbons with applications in environmental bioremediation. [Copyright &y& Elsevier]
AB - Copyright of Current Opinion in Microbiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOMICS
KW - MICROBIAL genomics
KW - ANALYTICAL chemistry
KW - BIODEGRADATION
KW - NUCLEOTIDE sequence
KW - HYDROCARBONS
KW - BIOREMEDIATION
KW - BACTERIA -- Metabolism
N1 - Accession Number: 41586801; Kim, Seong-Jae 1 Kweon, Ohgew 1 Cerniglia, Carl E 1; Email Address: carl.cerniglia@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR, United States; Source Info: Jun2009, Vol. 12 Issue 3, p301; Subject Term: PROTEOMICS; Subject Term: MICROBIAL genomics; Subject Term: ANALYTICAL chemistry; Subject Term: BIODEGRADATION; Subject Term: NUCLEOTIDE sequence; Subject Term: HYDROCARBONS; Subject Term: BIOREMEDIATION; Subject Term: BACTERIA -- Metabolism; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 211112 Natural Gas Liquid Extraction; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.mib.2009.03.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41586801&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Billal, Dewan Sakhawat
AU - Hotomi, Muneki
AU - Yan, Steve S.
AU - Fedorko, Daniel P.
AU - Shimada, Jun
AU - Fujihara, Keiji
AU - Yamanaka, Noboru
T1 - Loss of erythromycin resistance genes from strains of Streptococcus pyogenes that have developed resistance to levofloxacin
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2009/06//
VL - 64
IS - 2
M3 - Article
SP - 225
EP - 228
SN - 07328893
AB - Abstract: In the past 2 to 3 decades, erythromycin resistance in Streptococcus pyogenes has been decreasing, whereas fluoroquinolone resistance (or reduction in its susceptibility) has been reported often. Although a shift of M-type prevalence and decreased pressure from macrolides have been suggested for the decrease in erythromycin resistance, we hypothesized that this might also be a result of increased antimicrobial pressure from fluoroquinolone use. Levofloxacin resistance for 4 erythromycin-resistant parent strains was induced in vitro. Their mutants became highly resistant to the fluoroquinolones but lost their erythromycin resistance trait. Erythromycin resistance was fully restored by transconjugation with respective parent strains with either mefA- or ermTR-mediated mechanisms. [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG resistance in microorganisms -- Genetic aspects
KW - STREPTOCOCCUS pyogenes
KW - ERYTHROMYCIN
KW - DRUGS -- Effectiveness
KW - FLUOROQUINOLONES
KW - MACROLIDE antibiotics
KW - DIAGNOSTIC microbiology
KW - Erythromycin resistance
KW - Fluoroquinolone resistance
KW - Streptococcus pyogenes
KW - Transconjugation
N1 - Accession Number: 39782156; Billal, Dewan Sakhawat 1 Hotomi, Muneki 1 Yan, Steve S. 2 Fedorko, Daniel P. 3 Shimada, Jun 1 Fujihara, Keiji 1 Yamanaka, Noboru 1; Email Address: ynobi@wakayama-med.ac.jp; Affiliation: 1: Department of Otolaryngology, Wakayama Medical University, Wakayama 641-8509, Japan 2: Food and Drug Administration, Department of Health and Human Services, Rockville, MD 20855, USA 3: Department of Health and Human Services, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Source Info: Jun2009, Vol. 64 Issue 2, p225; Subject Term: DRUG resistance in microorganisms -- Genetic aspects; Subject Term: STREPTOCOCCUS pyogenes; Subject Term: ERYTHROMYCIN; Subject Term: DRUGS -- Effectiveness; Subject Term: FLUOROQUINOLONES; Subject Term: MACROLIDE antibiotics; Subject Term: DIAGNOSTIC microbiology; Author-Supplied Keyword: Erythromycin resistance; Author-Supplied Keyword: Fluoroquinolone resistance; Author-Supplied Keyword: Streptococcus pyogenes; Author-Supplied Keyword: Transconjugation; NAICS/Industry Codes: 621511 Medical Laboratories; NAICS/Industry Codes: 621510 Medical and diagnostic laboratories; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2009.01.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39782156&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schenker, Marc B.
AU - Pinkerton, Kent E.
AU - Mitchell, Diane
AU - Vallyathan, Val
AU - Elvine-Kreis, Brenda
AU - Green, Francis H. Y.
T1 - Pneumoconiosis from Agricultural Dust Exposure among Young California Farmworkers.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009/06//
VL - 117
IS - 6
M3 - Article
SP - 988
EP - 994
PB - Superintendent of Documents
SN - 00916765
AB - BACKGROUND: Agricultural workers are exposed to airborne pollutants, including organic and inorganic (mineral) dusts. OBJECTIVES: Lung autopsy specimens from consecutive coroner's cases of Hispanic males in Fresno County, California, (n = 112) were obtained to determine whether mineral dust exposure in agricultural work leads to pneumoconiosis. METHODS: The left lung was fixed by inflation. We evaluated airway and parenchymal pathology using standardized diagnostic criteria and semiquantitative grading schemata, including the grading of small airways for fibrosis and birefringent mineral dust particles. We analyzed lung dust burden on a subset of 37 lungs following bleach digestion, using scanning electron microscopy (SEM), X-ray spectrometry (XRS) and image analysis, and by X-ray diffraction for crystalline silica (CSi). Farmworkers comprised 51.5% and nonfarmworkers 48.5% of the samples. RESULTS: Proximal airways demonstrated little mineral dust accumulation, but membranous and respiratory bronchioles had wall thickening, remodeling, and inflammation associated with carbonaceous and mineral dust deposition. These changes were independently associated with agricultural work, cigarette smoking, and increased age. Mineral dust small airways disease, pneumoconiosis (macules and nodules), and pathologic changes consistent with chronic bronchitis, emphysema, and interstitial fibrosis predominated in farmworkers compared with nonfarmworkers. CSi, determined gravimetrically, and aluminum silicate particles, determined by SEM/XRS, were increased in the lungs of farmworkers compared with nonfarmworkers and were significantly (p < 0.05) associated with small airway disease and pneumoconiosis. CONCLUSION: Mineral dust exposure is associated with increased small airway disease and pneumoconiosis among California farmworkers; however, the clinical significance and natural history of these changes remains to be determined. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Agricultural laborers
KW - Air pollution
KW - Mineral dusts
KW - Lungs -- Dust diseases
KW - Scanning electron microscopy
KW - X-ray spectroscopy
KW - Image analysis
KW - Fresno County (Calif.)
KW - California
KW - agriculture
KW - dust
KW - farmworker
KW - interstitial fibrosis
KW - pneumoconiosis
KW - respiratory
KW - small airways disease
N1 - Accession Number: 43302866; Schenker, Marc B. 1; Email Address: mbschenker@ucdavis.edu; Pinkerton, Kent E. 2; Mitchell, Diane 1; Vallyathan, Val 3; Elvine-Kreis, Brenda 1; Green, Francis H. Y. 4; Affiliations: 1: Department of Public Health Sciences, National Institute for Occupational Safety and Health, Morgantown, West Virginia, SA; 2: Center for Health and the Environment University of California at Davis, Davis, California, USA; 3: Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, SA; 4: Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada; Issue Info: Jun2009, Vol. 117 Issue 6, p988; Thesaurus Term: Agricultural laborers; Thesaurus Term: Air pollution; Thesaurus Term: Mineral dusts; Subject Term: Lungs -- Dust diseases; Subject Term: Scanning electron microscopy; Subject Term: X-ray spectroscopy; Subject Term: Image analysis; Subject: Fresno County (Calif.); Subject: California; Author-Supplied Keyword: agriculture; Author-Supplied Keyword: dust; Author-Supplied Keyword: farmworker; Author-Supplied Keyword: interstitial fibrosis; Author-Supplied Keyword: pneumoconiosis; Author-Supplied Keyword: respiratory; Author-Supplied Keyword: small airways disease; NAICS/Industry Codes: 115115 Farm Labor Contractors and Crew Leaders; NAICS/Industry Codes: 115110 Support activities for crop production; Number of Pages: 7p; Illustrations: 4 Color Photographs, 1 Diagram, 7 Charts, 1 Graph; Document Type: Article
L3 - 10.1289/ehp.0800144
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43302866&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PETERSON, KRISTINA
AU - AMANDUS, HARLAN
AU - WASSELL, JAMES T.
T1 - Reducing Firefighter Vehicle Crash Fatalities.
JO - Fire Engineering
JF - Fire Engineering
Y1 - 2009/06//
VL - 162
IS - 6
M3 - Article
SP - 79
EP - 84
PB - PennWell Corporation
SN - 00152587
AB - The article focuses on recommendations by the U.S. National Institute for Occupational Safety and Health (NIOSH) in 2009 for fire departments to avoid fatalities and injuries in firefighters on duty due to motor vehicle accidents. It advises apparatus operators and drivers of fire department vehicles to undergo training and to take a refresher training twice every year. It emphasizes the need for all fire departments to impose a mandatory order for the use of seat belts through standard operating procedures (SOP) and implementation.
KW - TRAFFIC safety
KW - FIRE fighters
KW - FIRE departments -- Officials & employees
KW - TRAINING
KW - AUTOMOBILE seat belts
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 41876559; PETERSON, KRISTINA 1 AMANDUS, HARLAN 2 WASSELL, JAMES T. 3; Affiliation: 1: Senior research director, RTI International 2: Chief, Analysis and Field Evaluations Branch, Division of Safety Research, National Institute for Occupational Safety and Health 3: National Institute for Occupational Safety and Health; Source Info: Jun2009, Vol. 162 Issue 6, p79; Subject Term: TRAFFIC safety; Subject Term: FIRE fighters; Subject Term: FIRE departments -- Officials & employees; Subject Term: TRAINING; Subject Term: AUTOMOBILE seat belts; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 336360 Motor Vehicle Seating and Interior Trim Manufacturing; NAICS/Industry Codes: 415290 Other new motor vehicle parts and accessories merchant wholesalers; NAICS/Industry Codes: 326220 Rubber and Plastics Hoses and Belting Manufacturing; NAICS/Industry Codes: 316998 All Other Leather Good and Allied Product Manufacturing; NAICS/Industry Codes: 922160 Fire Protection; NAICS/Industry Codes: 913140 Municipal fire-fighting services; NAICS/Industry Codes: 912140 Provincial fire-fighting services; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Blodgett, Robert J.
T1 - Planning a serial dilution test with multiple dilutions
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009/06//
VL - 26
IS - 4
M3 - Article
SP - 421
EP - 424
SN - 07400020
AB - Abstract: The dilutions used in a serial dilution test determine which concentrations it can estimate well. Two criteria help to select how many and which dilutions to use. The first criterion is a low probability of outcomes with either all growth or all non-growth tubes at the concentrations of interest. The second criterion considers how far the estimated concentration (MPN) is likely to be from the actual concentration. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DILUTION
KW - MICROBIAL cultures
KW - MICROBIOLOGY -- Technique
KW - EFFECT of antibiotics on microorganisms
KW - PROBABILITY theory
KW - MICROBIAL growth
KW - Microbial concentration
KW - MPN, most probable number
KW - Test design
N1 - Accession Number: 37820309; Blodgett, Robert J. 1; Email Address: robert.blodgett@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Center for Applied Nutrition and Food Safety, 5100 Paint Branch Parkway, College Park, MD 20740, United States; Source Info: Jun2009, Vol. 26 Issue 4, p421; Subject Term: DILUTION; Subject Term: MICROBIAL cultures; Subject Term: MICROBIOLOGY -- Technique; Subject Term: EFFECT of antibiotics on microorganisms; Subject Term: PROBABILITY theory; Subject Term: MICROBIAL growth; Author-Supplied Keyword: Microbial concentration; Author-Supplied Keyword: MPN, most probable number; Author-Supplied Keyword: Test design; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.fm.2009.02.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37820309&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kagan, Valerian E.
AU - Bayır, Hülya A.
AU - Belikova, Natalia A.
AU - Kapralov, Olexandr
AU - Tyurina, Yulia Y.
AU - Tyurin, Vladimir A.
AU - Jiang, Jianfei
AU - Stoyanovsky, Detcho A.
AU - Wipf, Peter
AU - Kochanek, Patrick M.
AU - Greenberger, Joel S.
AU - Pitt, Bruce
AU - Shvedova, Anna A.
AU - Borisenko, Grigory
T1 - Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2009/06//
VL - 46
IS - 11
M3 - Article
SP - 1439
EP - 1453
SN - 08915849
AB - Abstract: Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c’s conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria—its asymmetric transmembrane distribution and mechanisms of collapse, the regulation of its synthesis, remodeling, and fatty acid composition—are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOCHROME c
KW - CARDIOLIPIN
KW - MITOCHONDRIA
KW - CELLULAR signal transduction
KW - PEROXIDATION
KW - CELL death
KW - OXIDATION-reduction reaction
KW - FREE radicals (Chemistry)
KW - (2-hydroxyaminovinyl)triphenylphosphonium ( HVTP )
KW - 1,1′,2-trioleoyl-2′-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]–CL ( NBD–CL )
KW - acyl-CoA:lysocardiolipin acyltransferase 1 ( ALCAT1 )
KW - Apoptosis
KW - Autophagy
KW - Cardiolipin
KW - cardiolipin ( CL )
KW - cyclooxygenase ( COX )
KW - Cytochrome c
KW - cytochrome c peroxidase ( CcP )
KW - cytochromec ( cyt c )
KW - dilyso-CL ( DLCL )
KW - dioleoylglycero-3-phosphoinositol 3,4,5-trisphosphate ( PIP3 )
KW - dioleoylglycero-3-phosphoinositol 4,5-bisphosphate ( PIP2 )
KW - fatty acid hydroperoxide ( FA-OOH )
KW - fluorescence resonance energy transfer ( FRET )
KW - Free radicals
KW - horseradish peroxidase ( HRP )
KW - hydroperoxy-CL ( CL-OOH )
KW - inner mitochondrial membrane ( IMM )
KW - Lipidomics
KW - Mitochondrial targeting
KW - monolyso-CL ( MLCL )
KW - myeloperoxidase ( MPO )
KW - Oxidative stress
KW - Peroxidase
KW - phosphatidic acid ( PA )
KW - phosphatidylcholine ( PC )
KW - phosphatidylglycerol ( PG )
KW - phosphatidylserine ( PS )
KW - phospholipid scramblase-3 ( PLS-3 )
KW - superoxide dismutase ( SOD )
KW - tetralinoleoyl-CL ( TLCL )
KW - tetramyristoyl-CL ( TMCL )
KW - tetraoleoyl-CL ( TOCL )
N1 - Accession Number: 38804853; Kagan, Valerian E. 1,2; Email Address: kagan@pitt.edu Bayır, Hülya A. 1,3,4 Belikova, Natalia A. 1,2 Kapralov, Olexandr 1,2 Tyurina, Yulia Y. 1,2 Tyurin, Vladimir A. 1,2 Jiang, Jianfei 1,2 Stoyanovsky, Detcho A. 5 Wipf, Peter 6 Kochanek, Patrick M. 3,4 Greenberger, Joel S. 7 Pitt, Bruce 2 Shvedova, Anna A. 8 Borisenko, Grigory 9; Affiliation: 1: Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA 2: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA 3: Safar Center for Resuscitation Research, Pittsburgh, PA 15260, USA 4: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA 5: Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA 6: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA 7: Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, USA 8: Physiology/Pathology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 9: Research Institute of Physico-Chemical Medicine, Moscow, Russian Federation; Source Info: Jun2009, Vol. 46 Issue 11, p1439; Subject Term: CYTOCHROME c; Subject Term: CARDIOLIPIN; Subject Term: MITOCHONDRIA; Subject Term: CELLULAR signal transduction; Subject Term: PEROXIDATION; Subject Term: CELL death; Subject Term: OXIDATION-reduction reaction; Subject Term: FREE radicals (Chemistry); Author-Supplied Keyword: (2-hydroxyaminovinyl)triphenylphosphonium ( HVTP ); Author-Supplied Keyword: 1,1′,2-trioleoyl-2′-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]–CL ( NBD–CL ); Author-Supplied Keyword: acyl-CoA:lysocardiolipin acyltransferase 1 ( ALCAT1 ); Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Autophagy; Author-Supplied Keyword: Cardiolipin; Author-Supplied Keyword: cardiolipin ( CL ); Author-Supplied Keyword: cyclooxygenase ( COX ); Author-Supplied Keyword: Cytochrome c; Author-Supplied Keyword: cytochrome c peroxidase ( CcP ); Author-Supplied Keyword: cytochromec ( cyt c ); Author-Supplied Keyword: dilyso-CL ( DLCL ); Author-Supplied Keyword: dioleoylglycero-3-phosphoinositol 3,4,5-trisphosphate ( PIP3 ); Author-Supplied Keyword: dioleoylglycero-3-phosphoinositol 4,5-bisphosphate ( PIP2 ); Author-Supplied Keyword: fatty acid hydroperoxide ( FA-OOH ); Author-Supplied Keyword: fluorescence resonance energy transfer ( FRET ); Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: horseradish peroxidase ( HRP ); Author-Supplied Keyword: hydroperoxy-CL ( CL-OOH ); Author-Supplied Keyword: inner mitochondrial membrane ( IMM ); Author-Supplied Keyword: Lipidomics; Author-Supplied Keyword: Mitochondrial targeting; Author-Supplied Keyword: monolyso-CL ( MLCL ); Author-Supplied Keyword: myeloperoxidase ( MPO ); Author-Supplied Keyword: Oxidative stress; Author-Supplied Keyword: Peroxidase; Author-Supplied Keyword: phosphatidic acid ( PA ); Author-Supplied Keyword: phosphatidylcholine ( PC ); Author-Supplied Keyword: phosphatidylglycerol ( PG ); Author-Supplied Keyword: phosphatidylserine ( PS ); Author-Supplied Keyword: phospholipid scramblase-3 ( PLS-3 ); Author-Supplied Keyword: superoxide dismutase ( SOD ); Author-Supplied Keyword: tetralinoleoyl-CL ( TLCL ); Author-Supplied Keyword: tetramyristoyl-CL ( TMCL ); Author-Supplied Keyword: tetraoleoyl-CL ( TOCL ); Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2009.03.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38804853&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongdao Meng
AU - Wamsley, Brenda
AU - Liebel, Diane
AU - Dixon, Denise
AU - Eggert, Gerald
AU - Van Nostrand, Joan
T1 - Urban—Rural Differences in the Effect of a Medicare Health Promotion and Disease Self- Management Program on Physical Function and Health Care Expenditures.
JO - Gerontologist
JF - Gerontologist
Y1 - 2009/06//
VL - 49
IS - 3
M3 - Article
SP - 407
EP - 417
SN - 00169013
AB - Purpose: To evaluate the impact of a multicomponent health promotion and disease self-management intervention on physical function and health care expenditures among Medicare beneficiaries. To determine if these outcomes vary by urban or rural residence. Design and Methods: We analyzed data from a 22-month randomized controlled trial of a health promotion/disease self-management program that included 766 elderly Medicare beneficiaries from western New York, West Virginia, and Ohio. Physical function was measured by changes in self-reported dependencies in activities of daily living over the study period. Total health care expenditures were measured by aggregating expenditures from major sources (acute, postacute, and long-term care). We used ordinary least squares models to examine the effects of the intervention on both physical function and cost outcomes during the 22-month period. Results: The results indicated that the intervention reduced physical functional decline by 54% (p .03) in the study sample. Stratified analyses showed that the intervention effect was much stronger in the rural sample. Mean total health care expenditures were 11% ($3,100, p = .30) lower in the intervention group. The effects of the intervention on average health care expenditures were similar among urban and rural participants. Implications: The intervention offered a promising strategy for reducing decline in physical function and potentially lowering total health care expenditures for high-risk Medicare beneficiaries, especially for those in rural areas. Future studies need to investigate whether the findings can be replicated in other types of rural areas through a refined intervention and better targeting of the study population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Gerontologist is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH promotion
KW - MEDICAL care costs
KW - MEDICAL economics
KW - MEDICARE
KW - HEALTH insurance -- United States
KW - CITIES & towns
KW - MEDICAL care -- United States
KW - UNITED States
KW - Disease management
KW - Expenditures
KW - Health promotion
KW - Prevention
KW - Rural
N1 - Accession Number: 41894075; Hongdao Meng 1; Email Address: hongdao.meng@stonybrook.edu Wamsley, Brenda 2 Liebel, Diane 3 Dixon, Denise 4 Eggert, Gerald 5 Van Nostrand, Joan 6; Affiliation: 1: Department of Preventive Medicine, State University of New York at Stony Brook, HSC, Level 3, Rm071, NY 11794-8338 2: Department of Social Work, West Virginia State University, Institute, West Virginia 3: School of Nursing, University of Rochester, Rochester, New York 4: University Hospital, State University of New York at Stony Brook, Stony Brook, New York 5: Monroe County Long Term Care Program, Inc., East Rochester, New York 6: Office of Rural Health Policy, Health Resources and Services Administration, DHHS, Rockville, Maryland; Source Info: Jun2009, Vol. 49 Issue 3, p407; Subject Term: HEALTH promotion; Subject Term: MEDICAL care costs; Subject Term: MEDICAL economics; Subject Term: MEDICARE; Subject Term: HEALTH insurance -- United States; Subject Term: CITIES & towns; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; Author-Supplied Keyword: Disease management; Author-Supplied Keyword: Expenditures; Author-Supplied Keyword: Health promotion; Author-Supplied Keyword: Prevention; Author-Supplied Keyword: Rural; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/geront/gnp057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41894075&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Selden, Thomas M.
T1 - The Within-Year Concentration of Medical Care: Implications for Family Out-of-Pocket Expenditure Burdens.
JO - Health Services Research
JF - Health Services Research
Y1 - 2009/06//
VL - 44
IS - 3
M3 - Article
SP - 1029
EP - 1051
PB - Wiley-Blackwell
SN - 00179124
AB - Objective. To examine the within-year concentration of family health care and the resulting exposure of families to short periods of high expenditure burdens. Data Source. Household data from the pooled 2003 and 2004 Medical Expenditure Panel Survey (MEPS) yielding nationally representative estimates for the nonelderly civilian noninstitutionalized population. Study Design. The paper examines the within-year concentration of family medical care use and the frequency with which family out-of-pocket expenditures exceeded 20 percent of family income, computed at the annual, quarterly, and monthly levels. Principal Findings. On average among families with medical care, 49 percent of all (charge-weighted) care occurred in a single month, and 63 percent occurred in a single quarter). Nationally, 27 percent of the study population experienced at least 1 month in which out-of-pocket expenditures exceeded 20 percent of income. Monthly 20 percent burden rates were highest among the poor, at 43 percent, and were close to or above 30 percent for all but the highest income group (families above four times the federal poverty line). Conclusions. Within-year spikes in health care utilization can create financial pressures missed by conventional annual burden analyses. Within-year health-related financial pressures may be especially acute among lower-income families due to low asset holdings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UTILIZATION review (Medical care)
KW - FAMILIES
KW - MEDICAL care
KW - INCOME
KW - HEALTH surveys
KW - MEDICAL care costs
KW - UNITED States
KW - burdens
KW - expenditures
KW - Medical utilization
N1 - Accession Number: 39772606; Selden, Thomas M. 1; Email Address: tselden@ahrq.gov; Affiliation: 1: Department of Health and Human Services, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850; Source Info: Jun2009, Vol. 44 Issue 3, p1029; Subject Term: UTILIZATION review (Medical care); Subject Term: FAMILIES; Subject Term: MEDICAL care; Subject Term: INCOME; Subject Term: HEALTH surveys; Subject Term: MEDICAL care costs; Subject Term: UNITED States; Author-Supplied Keyword: burdens; Author-Supplied Keyword: expenditures; Author-Supplied Keyword: Medical utilization; Number of Pages: 23p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1475-6773.2009.00963.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105407605
T1 - The within-year concentration of medical care: implications for family out-of-pocket expenditure burdens.
AU - Selden TM
Y1 - 2009/06//
N1 - Accession Number: 105407605. Language: English. Entry Date: 20090911. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Economic Aspects of Illness
KW - Economics -- Economics
KW - Health Care Costs -- Statistics and Numerical Data
KW - Income
KW - Adult
KW - Child
KW - Family Characteristics
KW - Health Services -- Economics
KW - Health Services -- Utilization
KW - Insurance Coverage -- Economics
KW - Medically Uninsured -- Statistics and Numerical Data
KW - Medicare -- Economics
KW - Patient Care
KW - Poverty -- Economics
KW - Private Sector -- Economics
KW - Prospective Studies
KW - Public Sector -- Economics
KW - Socioeconomic Factors
KW - Surveys
KW - Taxes
KW - Time Factors
KW - United States
KW - Human
SP - 1029
EP - 1051
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 44
IS - 3
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Department of Health and Human Services, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. tselden@ahrq.gov
U2 - PMID: 19674431.
DO - 10.1111/j.1475-6773.2009.00963.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Babu, Uma
AU - Wiesenfeld, Paddy
AU - Gaines, Dennis
AU - Raybourne, Richard B.
T1 - Effect of long chain fatty acids on Salmonella killing, superoxide and nitric oxide production by chicken macrophages
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/06//
VL - 132
IS - 1
M3 - Article
SP - 67
EP - 72
SN - 01681605
AB - Abstract: The objective of this study was to investigate the effect of uptake of different commonly consumed long chain fatty acids on superoxide (O2−), nitric oxide (NO) production, and ability to kill Salmonella enterica serotype typhimurium (S. typhimurium) by chicken macrophages (HD11 cells). All the fatty acids were taken up by HD11 cells with stearic acid uptake higher than polyunsaturated fatty acids. Uptake of green fluorescent protein-labeled bacteria and the viability of HD11 cells (measured by flow cytometry) was not affected by any of the fatty acids tested. Bacterial clearance (measured by the plating of sorted viable infected cells) was significantly higher with n −3 fatty acids α-linolenic acid (ALA) and docosahexanoic acid (DHA). However, stearic acid (SA) and the n −6 fatty acid, arachidonic acid (ARA) did not influence S. typhimurium killing by HD11 cells. The improved S. typhimurium clearance by ALA and DHA was not associated with increased NO or O2− production by HD11 cells. These results suggest a role for n −3 polyunsaturated fatty acids in Salmonella clearance by chicken macrophages however in vivo studies are essential to confirm their efficacy in controlling Salmonella infection in chickens and contamination in shell eggs. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Fatty acids
KW - Nitric oxide
KW - Salmonella
KW - Gram-negative bacteria
KW - Chickens
KW - Superoxides
KW - Macrophages
KW - Chicken macrophage functions
KW - Fatty acid uptake
KW - S. typhimurium
N1 - Accession Number: 39345514; Babu, Uma 1; Email Address: uma.babu@fda.hhs.gov; Wiesenfeld, Paddy 2; Gaines, Dennis 1; Raybourne, Richard B. 1; Affiliations: 1: Immunobiology Branch, Food and Drug Administration, Laurel, MD 20708, USA; 2: Neurotoxicology and In Vitro Toxicology Branch (NIVTB), Food and Drug Administration, Laurel, MD 20708, USA; Issue Info: Jun2009, Vol. 132 Issue 1, p67; Thesaurus Term: Fatty acids; Thesaurus Term: Nitric oxide; Thesaurus Term: Salmonella; Thesaurus Term: Gram-negative bacteria; Thesaurus Term: Chickens; Subject Term: Superoxides; Subject Term: Macrophages; Author-Supplied Keyword: Chicken macrophage functions; Author-Supplied Keyword: Fatty acid uptake; Author-Supplied Keyword: S. typhimurium; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2009.03.017
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cutlip, Robert G.
AU - Baker, Brent A.
AU - Hollander, Melinda
AU - Ensey, James
T1 - Injury and adaptive mechanisms in skeletal muscle
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
Y1 - 2009/06//
VL - 19
IS - 3
M3 - Article
SP - 358
EP - 372
SN - 10506411
AB - Abstract: Work-related musculoskeletal disorders (MSD) are a major concern in the United States. Overexertion and repetitive motion injuries dominate reporting of lost-time MSD incidents. Over the past three decades, there has been much study on contraction-induced skeletal muscle injury. The effect of the biomechanical loading signature that includes velocity, range of motion, the number of repetitions, force, work-rest cycle, and exposure duration has been studied. More recently, the effect of aging on muscle injury susceptibility and regeneration has been studied. This review will focus on contraction-induced skeletal muscle injury, the effects of repetitions, range of motion, work-rest cycles, and aging on injury susceptibility and regenerative and adaptive pathways. The different physiological phenomena responsive to overt muscle injury versus adaptation will be distinguished. The inherent capability of skeletal muscle to adapt to mechanical loading, given the appropriate exposure signature will also be discussed. Finally, we will submit that repeated high-intensity mechanical loading is a desirable means to attenuate the effects of sarcopenia, and may be the most effective and appealing mode of physical activity to counteract the effects often observed with musculo-skeletal dysfunction in the workplace. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electromyography & Kinesiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCULOSKELETAL system -- Diseases
KW - OVEREXERTION injuries
KW - OVERUSE injuries
KW - STRIATED muscle
KW - LOADS (Mechanics)
KW - AGE factors in disease
KW - MUSCLES -- Regeneration
KW - BIOMECHANICS
KW - OCCUPATIONAL diseases
KW - UNITED States
KW - Adaptation
KW - Aging
KW - Regeneration
KW - Skeletal muscle injury
N1 - Accession Number: 37229674; Cutlip, Robert G.; Email Address: RGC8@CDC.GOV Baker, Brent A. 1 Hollander, Melinda 1 Ensey, James 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, 1095 Don Nehlen Drive, M/S 2027, Morgantown, WV 26506, USA; Source Info: Jun2009, Vol. 19 Issue 3, p358; Subject Term: MUSCULOSKELETAL system -- Diseases; Subject Term: OVEREXERTION injuries; Subject Term: OVERUSE injuries; Subject Term: STRIATED muscle; Subject Term: LOADS (Mechanics); Subject Term: AGE factors in disease; Subject Term: MUSCLES -- Regeneration; Subject Term: BIOMECHANICS; Subject Term: OCCUPATIONAL diseases; Subject Term: UNITED States; Author-Supplied Keyword: Adaptation; Author-Supplied Keyword: Aging; Author-Supplied Keyword: Regeneration; Author-Supplied Keyword: Skeletal muscle injury; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.jelekin.2008.06.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37229674&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105490094
T1 - Injury and adaptive mechanisms in skeletal muscle.
AU - Cutlip RG
AU - Baker BA
AU - Hollander M
AU - Ensey J
Y1 - 2009/06//
N1 - Accession Number: 105490094. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 9109125.
KW - Muscle, Skeletal -- Injuries
KW - Muscle, Skeletal -- Physiopathology
KW - Muscular Diseases -- Physiopathology
KW - Occupational Diseases -- Physiopathology
KW - Adaptation, Physiological
KW - Animals
SP - 358
EP - 372
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
JA - J ELECTROMYOGR KINESIOL
VL - 19
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 1050-6411
AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Don Nehlen Drive, M/S 2027, Morgantown, WV 26506, USA. RGC8@CDC.GOV
U2 - PMID: 18768331.
DO - 10.1016/j.jelekin.2008.06.007
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - DAY, J. B.
AU - WHITING, R. C.
T1 - Development of a Macrophage Cell Culture Method To Isolate and Enrich Francisella tularensis from Food Matrices for Subsequent Detection by Real-Time PCR.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/06//
VL - 72
IS - 6
M3 - Article
SP - 1156
EP - 1164
SN - 0362028X
AB - Francisella tularensis is a gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are no techniques currently available to detect this organism in specific food matrices. In this study, a macrophage cell culture system is combined with real-time PCR to identify F. tularensis in food matrices. The method utilizes a mouse macrophage cell line (RAW 264.7) as host for the isolation and intracellular replication of F. tularensis. Exposure of macrophages to F. tularensis-contaminated food matrices results in uptake and intracellular replication of the bacteria, which can be subsequently detected by real-time PCR analysis of the DNA released from infected macrophage cell lysates. Macrophage monolayers were exposed to infant formula, liquid egg whites, and lettuce contaminated with varying quantities of F. tularensis. As few as 10 CFU/ml (or CFU per gram) F. tularensis was detected in infant formula and lettuce after 5 h postinfection. As few as 10 CFU/ml F. tularensis was detected in liquid egg whites after 18 h postinfection, Intracellular F. tularensis could also be isolated on Mueller-Hinton medium from lysates of macrophages infected with the bacteria in infant formula, liquid egg whites, and lettuce for subsequent confirmatory identification. This method is the first to successfully identify F. tularensis from select food matrices. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tularemia
KW - Food contamination
KW - Gram-negative bacteria
KW - Francisella tularensis
KW - Macrophages
KW - Cell culture
KW - Polymerase chain reaction
N1 - Accession Number: 42095620; DAY, J. B. 1; Email Address: james.day@fda.hhs.gov; WHITING, R. C.; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-712, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Jun2009, Vol. 72 Issue 6, p1156; Thesaurus Term: Tularemia; Thesaurus Term: Food contamination; Thesaurus Term: Gram-negative bacteria; Subject Term: Francisella tularensis; Subject Term: Macrophages; Subject Term: Cell culture; Subject Term: Polymerase chain reaction; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tarantino-Hutchison, Lauren M.
AU - Sorrentino, Claudio
AU - Nadas, Arthur
AU - Zhu, Yiwen
AU - Rubin, Edward M.
AU - Tinkle, Sally S.
AU - Weston, Ainsley
AU - Gordon, Terry
T1 - Genetic determinants of sensitivity to beryllium in mice.
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
Y1 - 2009/06//
VL - 6
IS - 2
M3 - Article
SP - 130
EP - 135
PB - Taylor & Francis Ltd
SN - 1547691X
AB - Chronic beryllium disease (CBD), an irreversible, debilitating granulomatous lung disease is caused by exposure to beryllium. This occupational hazard occurs in primary production and machining of Be-metal, BeO, beryllium - containing alloys, and other beryllium products. CBD begins as an MHC Class II-restricted, TH1 hypersensitivity, and the Human Leukocyte Antigen, HLA-DPB1E 69, is associated with risk of developing CBD. Because inbred strains of mice have not provided good models of CBD to date, three strains of HLA-DPB1 transgenic mice in an FVB/N background were developed; each contains a single allele of HLA-DPB1 that confers a different magnitude of risk for chronic beryllium disease: HLA-DPB1*0401 (OR ≈ 0.2), HLA-DPB1*0201 (OR ≈ 3), and HLA-DPB1*1701 (OR ≈ 46). The mouse ear swelling test (MEST) was employed to determine if these different alleles would support a hypersensitivity response to beryllium. Mice were first sensitized on the back and subsequently challenged on the ear. In separate experiments, mice were placed into one of three groups (sensitization/challenge): C/C, C/Be, and Be/Be. In the HLA-DPB1*1701 mice, the strain with the highest risk transgene, the Be/Be group was the only group that displayed significant maximum increased ear thickness of 19.6% ± 3.0% over the baseline measurement (p < 0.05). No significant changes were observed in the other transgenic strains for any treatment condition. In addition, inter-strain differences in response to beryllium in seven inbred strains were investigated through use of the MEST, these included: FVB/N, AKR, Balb/c, C3H/HeJ, C57/BL6, DBA/2, and SJL/J. The FVB/N strain was least responsive, while the SJL/J and C57/BL6 strains were the highest responders. Our results suggest that the HLA-DPB1*1701 transgene product is an important risk factor for induction of the beryllium-sensitive phenotype. This model should be a useful tool for investigating beryllium sensitization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Immunotoxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetics
KW - Beryllium
KW - Occupational hazards
KW - Lung diseases
KW - Chronic granulomatous disease
KW - chronic beryllium disease
KW - mouse model
N1 - Accession Number: 43448245; Tarantino-Hutchison, Lauren M. 1; Sorrentino, Claudio 1; Nadas, Arthur 1; Zhu, Yiwen 2; Rubin, Edward M. 2; Tinkle, Sally S. 3; Weston, Ainsley 4; Gordon, Terry 1; Email Address: terry.gordon@nyumc.org; Affiliations: 1: Department of Environmental Medicine, NYU School of Medicine, Tuxedo, New York, USA; 2: Department of Genome Sciences, Lawrence Berkeley National Laboratory, Berkeley, California, USA; 3: Office of the Director, National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA; 4: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Issue Info: Jun2009, Vol. 6 Issue 2, p130; Thesaurus Term: Genetics; Thesaurus Term: Beryllium; Thesaurus Term: Occupational hazards; Subject Term: Lung diseases; Subject Term: Chronic granulomatous disease; Author-Supplied Keyword: chronic beryllium disease; Author-Supplied Keyword: mouse model; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1080/15476910902977399
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Nies-Kraske, Elizabeth
AU - Schacker, Timothy W.
AU - Condoluci, David
AU - Orenstein, Jan
AU - Brenchley, Jason
AU - Fox, Cecil
AU - Daucher, Marybeth
AU - Dewar, Robin
AU - Urban, Elizabeth
AU - Hill, Brenna
AU - Guenaga, Javier
AU - Hoover, Shelley
AU - Maldarelli, Frank
AU - Hallahan, Claire W.
AU - Horn, Judith
AU - Kottilil, Shyamasundaran
AU - Tae-Wook Chun
AU - Folino, Marlene
AU - Palmer, Sara
AU - Wiegand, Ann
T1 - Evaluation of the Pathogenesis of Decreasing CD4+ T Cell Counts in Human Immunodeficiency Virus Type 1-Infected Patients Receiving Successfully Suppressive Antiretroviral Therapy.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/06//6/1/2009
VL - 199
IS - 11
M3 - Article
SP - 1648
EP - 1656
SN - 00221899
AB - Most human immunodeficiency virus (HIV)-infected individuals experience increases in peripheral CD4+ T cell counts with suppressive antiretroviral therapy (ART) that achieves plasma HIV RNA levels that are less than the limit of detection. However, some individuals experience decreasing CD4+ T cell counts despite suppression of plasma viremia. We evaluated 4 patients with a history of CD4+ T cell decline despite successfully suppressive ART, from a median of 719 cells/mm3 (range, 360-1141 cells/mm3) to 227 cells/mm3 (range, 174-311 cells/mm3) over a period of 18-24 months; 3 of the patients were receiving tenofovir and didanosine, which may have contributed to this decrease. There was no evidence of HIV replication, nor of antiretroviral drug resistance in the blood or lymphoid tissue, or increased proliferation or decreased thymic production of naive CD4+ T cells. All 4 patients had significant fibrosis of the T cell zone of lymphoid tissue, which appeared to be an important factor in the failure to reconstitute T cells. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIV-positive persons
KW - DIAGNOSIS
KW - HIV (Viruses)
KW - RESEARCH
KW - CD4 antigen
KW - T cells
KW - COMBINATION drug therapy
KW - LYMPHOID tissue
KW - DISEASES
KW - VIREMIA
KW - BLOODBORNE infections
KW - THERAPEUTIC use
KW - GENETIC aspects
N1 - Accession Number: 41534700; Nies-Kraske, Elizabeth 1 Schacker, Timothy W. 2 Condoluci, David 3 Orenstein, Jan 4 Brenchley, Jason 5 Fox, Cecil 6 Daucher, Marybeth 1 Dewar, Robin 7 Urban, Elizabeth 1 Hill, Brenna 5 Guenaga, Javier 5 Hoover, Shelley 6 Maldarelli, Frank 8 Hallahan, Claire W. 1 Horn, Judith 4 Kottilil, Shyamasundaran 1 Tae-Wook Chun 1 Folino, Marlene 3 Palmer, Sara 8 Wiegand, Ann 8; Affiliation: 1: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda 2: Department of Medicine, University of Minnesota, Minneapolis 3: Garden State Infectious Diseases Associates Clinic, Voorhees, New Jersey 4: George Washington University, Washington, DC 5: Human Immunology Section, Vaccine Research Center, Bethesda 6: Molecular Histology Laboratories, Rockville, Maryland 7: SAIC-Frederick, NCIFrederick, Frederick 8: National Cancer Institute (NCI), National Institutes of Health, US Department of Health and Human Services, Bethesda; Source Info: 6/1/2009, Vol. 199 Issue 11, p1648; Subject Term: HIV-positive persons; Subject Term: DIAGNOSIS; Subject Term: HIV (Viruses); Subject Term: RESEARCH; Subject Term: CD4 antigen; Subject Term: T cells; Subject Term: COMBINATION drug therapy; Subject Term: LYMPHOID tissue; Subject Term: DISEASES; Subject Term: VIREMIA; Subject Term: BLOODBORNE infections; Subject Term: THERAPEUTIC use; Subject Term: GENETIC aspects; Number of Pages: 9p; Illustrations: 3 Diagrams, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1086/598980
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van den Berg, Frits
T1 - Low Frequency Noise and phantom sounds.
JO - Journal of Low Frequency Noise, Vibration & Active Control
JF - Journal of Low Frequency Noise, Vibration & Active Control
Y1 - 2009/06//
VL - 28
IS - 2
M3 - Article
SP - 105
EP - 116
SN - 02630923
AB - Suffering from more or less continuous and more or less steady low pitched sounds at home can be a serious threat to well-being. Often the sound source is not obvious or cannot be found. In many cases there is no clear evidence from the analysis of the ambient sound what the disturbing sound could be. Thus Low Frequency Noise (LFN) has become an ominous concept, a confrontation between sufferers asking for understanding and a solution and experts who are frequently helpless. From reported measurements one must conclude that at least in some cases it is improbable or even impossible that LFN is actually present at a relevant level. Although, even then, sufferers often are convinced there has to be a real, external source. A much simpler explanation may be there is not, but the sound originates within the person. When brought in a very quiet environment, normally hearing people often hear low pitched and other sounds not physically present: phantom sounds. A hypothesis is that, when the presence of a physical sound cannot be confirmed, LFN sufferers hear low pitched phantom sounds as other people would in a dead quiet place, but do not recognize it than such. It may help sufferers to know this is a neurological phenomenon, not a psychological one. More knowledge of the sufferer about such sounds combined with the presence of more real sound at home could help to relieve the complaints. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Low Frequency Noise, Vibration & Active Control is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AUDIO frequency
KW - NOISE -- Psychological aspects
KW - FREQUENCIES of oscillating systems
KW - FREQUENCY response (Dynamics)
KW - HEARING levels
KW - RESEARCH
KW - TRANSMISSION of sound
N1 - Accession Number: 49020934; van den Berg, Frits 1; Affiliation: 1: Public Health Service Amsterdam, Department of Environmental Health, PO Box 2200, 1000CE Amsterdam, Netherlands; Source Info: Jun2009, Vol. 28 Issue 2, p105; Subject Term: AUDIO frequency; Subject Term: NOISE -- Psychological aspects; Subject Term: FREQUENCIES of oscillating systems; Subject Term: FREQUENCY response (Dynamics); Subject Term: HEARING levels; Subject Term: RESEARCH; Subject Term: TRANSMISSION of sound; Number of Pages: 12p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gao, Pengfei
AU - Weise, Tyson
AU - Tomasovic, Beth
T1 - Development of a Computer Program for Permeation Testing Data Analysis.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/06//
VL - 6
IS - 6
M3 - Article
SP - 363
EP - 373
PB - Taylor & Francis Ltd
SN - 15459624
AB - A Microsoft Windows-compatible computer program, referred to as "Permeation Calculator," was developed at the National Institute for Occupational Safety and Health (NIOSH) to automate and standardize permeation testing data analysis. The program imports the data file collected during a permeation test and calculates relevant permeation parameters within a few seconds, based on a series of algorithms, strategies, and automated decision-making processes. It allows calculations of all the permeation parameters related to American Society for Testing and Materials (ASTM) F 739, International Organization for Standardization (ISO) 6529, and ASTM D 6978 standards, including standardized breakthrough time, normalized breakthrough time, breakthrough detection time, steady-state permeation rate, cumulative permeation mass at a given elapsed time, and elapsed time at a given cumulative permeation mass for either a closed-loop or an open-loop permeation test. For open-loop permeation testing, the software also allows changing sampling flowrate and allows calculations of average permeation rate and maximum permeation rate to see if the rates ever reach the threshold maximum for decision making. On completion, the software displays all the permeation parameters together with relevant information and the permeation curve as a report file in Microsoft Excel and text file formats. This software helps industrial hygienists and researchers to avoid labor-intensive hand calculations of the permeation parameters. The software also prevents experimenter bias, thus ensuring identical permeation parameters will be obtained from a given permeation testing data file. The Permeation Calculator is available either on the NIOSH website or on CD by request. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Protective clothing
KW - Industrial safety
KW - Computer programming
KW - Product safety
KW - Computer software
KW - Breakthrough time
KW - chemical protective clothing
KW - computer program
KW - cumulative permeation
KW - Permeation rate
KW - Permeation testing
N1 - Accession Number: 38028361; Gao, Pengfei 1; Email Address: PGao@cdc.gov; Weise, Tyson 2; Tomasovic, Beth 2; Affiliations: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania; 2: EG&G Technical Services, Inc., Pittsburgh, Pennsylvania; Issue Info: Jun2009, Vol. 6 Issue 6, p363; Thesaurus Term: Protective clothing; Thesaurus Term: Industrial safety; Subject Term: Computer programming; Subject Term: Product safety; Subject Term: Computer software; Author-Supplied Keyword: Breakthrough time; Author-Supplied Keyword: chemical protective clothing; Author-Supplied Keyword: computer program; Author-Supplied Keyword: cumulative permeation; Author-Supplied Keyword: Permeation rate; Author-Supplied Keyword: Permeation testing; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 541511 Custom Computer Programming Services; NAICS/Industry Codes: 541514 Computer systems design and related services (except video game design and development); NAICS/Industry Codes: 541519 Other Computer Related Services; Number of Pages: 11p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105494864
T1 - Development of a computer program for permeation testing data analysis.
AU - Gao P
AU - Weise T
AU - Tomasovic B
Y1 - 2009/06//
N1 - Accession Number: 105494864. Language: English. Entry Date: 20090522. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Data Analysis, Computer Assisted
KW - Permeability -- Evaluation
KW - Software Design
KW - Data Analysis Software
KW - Time Factors
KW - Human
SP - 363
EP - 373
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A Microsoft Windows-compatible computer program, referred to as 'Permeation Calculator,' was developed at the National Institute for Occupational Safety and Health (NIOSH) to automate and standardize permeation testing data analysis. The program imports the data file collected during a permeation test and calculates relevant permeation parameters within a few seconds, based on a series of algorithms, strategies, and automated decision-making processes. It allows calculations of all the permeation parameters related to American Society for Testing and Materials (ASTM) F 739, International Organization for Standardization (ISO) 6529, and ASTM D 6978 standards, including standardized breakthrough time, normalized breakthrough time, breakthrough detection time, steady-state permeation rate, cumulative permeation mass at a given elapsed time, and elapsed time at a given cumulative permeation mass for either a closed-loop or an open-loop permeation test. For open-loop permeation testing, the software also allows changing sampling flowrate and allows calculations of average permeation rate and maximum permeation rate to see if the rates ever reach the threshold maximum for decision making. On completion, the software displays all the permeation parameters together with relevant information and the permeation curve as a report file in Microsoft Excel and text file formats. This software helps industrial hygienists and researchers to avoid labor-intensive hand calculations of the permeation parameters. The software also prevents experimenter bias, thus ensuring identical permeation parameters will be obtained from a given permeation testing data file. The Permeation Calculator is available either on the NIOSH website or on CD by request.
SN - 1545-9624
AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania 15236, USA. PGao@cdc.gov
U2 - PMID: 19326268.
DO - 10.1080/15459620902864973
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105405857
T1 - Police work and subclinical atherosclerosis.
AU - Joseph PN
AU - Violanti JM
AU - Donahue R
AU - Andrew ME
AU - Trevisan M
AU - Burchfiel CM
AU - Dorn J
Y1 - 2009/06//
N1 - Accession Number: 105405857. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. Instrumentation: Center for Epidemiologic Studies Depression Scale (CES-D). Grant Information: Funded by the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, and also funded by the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). NLM UID: 9504688.
KW - Arteriosclerosis -- Epidemiology
KW - Police
KW - Adult
KW - Alcohol Drinking -- Epidemiology
KW - Arteriosclerosis -- Risk Factors
KW - Center for Epidemiological Studies Depression Scale
KW - Confidence Intervals
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Male
KW - Middle Age
KW - Multiple Regression
KW - New York
KW - P-Value
KW - Personality
KW - Psychological Tests
KW - Scales
KW - Smoking -- Epidemiology
KW - Human
SP - 700
EP - 707
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 51
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: Employment as an urban police officer was hypothesized to be associated with increased structural subclinical cardiovascular disease (CVD), measured by carotid artery intima-media thickness (IMT). METHODS: The sample of men and women consisted of police officers (n = 312) and the general population (n = 318), free of clinical CVD. RESULTS: Officers had elevated levels of age-adjusted CVD risk factors (blood pressure, total cholesterol, smoking prevalence) compared with the population sample. In age-, gender-, and traditional risk factor-adjusted models, police officers exhibited increased mean common carotid IMT (police = 0.67 mm, population = 0.64 mm; P = 0.03) and mean maximum carotid IMT (police = 0.99 mm, population = 0.95 mm; P = 0.13). CONCLUSIONS: Police officers have increased levels of atherosclerosis compared with a general population sample, which was not fully explained by elevated CVD risk factors; thereby potentially implicating other mechanisms whereby law enforcement work may increase CVD risk.
SN - 1076-2752
AD - Biostatistics and Epidemiology Branch, HealthEffects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road M/S 4050, Morgantown, WV 26505, USA. PNJoseph@cdc.gov
U2 - PMID: 19530342.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Schier, Joshua G.
AU - Rubin, Carol S.
AU - Miller, Dorothy
AU - Barr, Dana
AU - McGeehin, Michael A.
T1 - Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination.
JO - Journal of Public Health Policy
JF - Journal of Public Health Policy
Y1 - 2009/06//
VL - 30
IS - 2
M3 - Article
SP - 127
EP - 143
PB - Palgrave Macmillan Ltd.
SN - 01975897
AB - Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports of trace-back investigations into the etiology. The authors, therefore, conducted a systematic literature review on potential etiologies of these mass poisonings. The current available evidence suggests that substitution of DEG or DEG-containing compounds for pharmaceutical ingredients results from: (1) deception as to the true nature of certain ingredients by persons at some point in the pharmaceutical manufacturing process, and (2) failure to adhere to standardized quality control procedures in manufacturing pharmaceutical products intended for consumers. We discuss existing guidelines and new recommendations for prevention of these incidents.Journal of Public Health Policy (2009) 30, 127–143. doi:10.1057/jphp.2009.2 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Public Health Policy is the property of Palgrave Macmillan Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETHYLENE glycol
KW - DISEASES -- Causes & theories of causation
KW - NATIONAL health services
KW - PUBLIC health
KW - MEDICAL policy
KW - HEALTH care industry
KW - ENVIRONMENTAL aspects
KW - diethylene glycol
KW - mass poisoning
KW - poisoning
N1 - Accession Number: 43163717; Schier, Joshua G. 1; Email Address: jschier@cdc.gov Rubin, Carol S. 1 Miller, Dorothy 2 Barr, Dana 3 McGeehin, Michael A. 1; Affiliation: 1: Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA 2: United States Food and Drug Administration, Rockville, MD, USA 3: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA; Source Info: 2009, Vol. 30 Issue 2, p127; Subject Term: DIETHYLENE glycol; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: NATIONAL health services; Subject Term: PUBLIC health; Subject Term: MEDICAL policy; Subject Term: HEALTH care industry; Subject Term: ENVIRONMENTAL aspects; Author-Supplied Keyword: diethylene glycol; Author-Supplied Keyword: mass poisoning; Author-Supplied Keyword: poisoning; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 17p; Illustrations: 1 Black and White Photograph, 2 Charts; Document Type: Article
L3 - 10.1057/jphp.2009.2
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BENNETT, REGINALD W.
T1 - SEROLOGICAL ATTRACTION OF NONTOXIC EGG COMPONENT TO STAPHYLOCOCCAL ANTI-ENTEROTOXIN.
JO - Journal of Rapid Methods & Automation in Microbiology
JF - Journal of Rapid Methods & Automation in Microbiology
Y1 - 2009/06//
VL - 17
IS - 2
M3 - Article
SP - 223
EP - 232
SN - 10603999
AB - Raw whole liquid and dried eggs which were purported to contain staphylococcal enterotoxin were analyzed by a number of enzyme-linked immunosorbent assay (ELISA)-based methods. The initial evaluation was to establish whether the purported positive ELISA reactions were a result of toxin-anti-enterotoxin serological activity. A secondary consideration was to determine whether the putative protein occurred in the yolk and/or white portions of the eggs. A manual polyvalent detection system, manual monovalent ELISA and an automated polyvalent enzyme-linked fluorescent immunoassay were used to investigate this component in eggs. The ELISA results were instantaneous and showed strong positive reactions (false positives) with the manual and automated polyvalent systems, suggesting nonspecific binding of the egg-reactive component to one or more staphylococcal enterotoxin antibodies. Further analysis with the monovalent ELISA showed false-positive reactions when egg extracts were tested separately for enterotoxins A–E. The putative protein from fertilized eggs had caused false-positive reactions and the eggs did not contain preformed staphylococcal enterotoxin. PRACTICAL APPLICATIONS The analysis of raw whole liquid and dried eggs for staphylococcal enterotoxin must be performed with circumspection when applying serological systems which use whole antibody, as the resulting positive reaction could be a false-positive reaction due to a nontoxic component in eggs which reacts with the staphylococcal anti-enterotoxins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Rapid Methods & Automation in Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROTOXINS
KW - FOOD -- Microbiology
KW - STAPHYLOCOCCUS
KW - EGGS
KW - ENZYME-linked immunosorbent assay
KW - IMMUNOGLOBULINS
N1 - Accession Number: 41044140; BENNETT, REGINALD W. 1; Email Address: reginald.bennett@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740; Source Info: Jun2009, Vol. 17 Issue 2, p223; Subject Term: ENTEROTOXINS; Subject Term: FOOD -- Microbiology; Subject Term: STAPHYLOCOCCUS; Subject Term: EGGS; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: IMMUNOGLOBULINS; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 112310 Chicken Egg Production; Number of Pages: 10p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1111/j.1745-4581.2009.00168.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105520756
T1 - Utilization of substance abuse treatment services under Medicare, 2001-2002.
AU - Vandivort R
AU - Teich JL
AU - Cowell AJ
AU - Chen H
Y1 - 2009/06//
N1 - Accession Number: 105520756. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; USA. NLM UID: 8500909.
KW - Disabled
KW - Substance Use Disorders -- Rehabilitation
KW - Substance Use Rehabilitation Programs -- Utilization
KW - Age Factors
KW - Aged
KW - Diagnosis, Dual (Psychiatry)
KW - Female
KW - Male
KW - Medicare -- Statistics and Numerical Data
KW - Mental Disorders -- Complications
KW - Middle Age
KW - Resource Databases
KW - Substance Use Disorders -- Complications
KW - Substance Withdrawal Syndrome -- Rehabilitation
KW - United States
SP - 414
EP - 419
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
JA - J SUBST ABUSE TREAT
VL - 36
IS - 4
PB - Pergamon Press - An Imprint of Elsevier Science
SN - 0740-5472
AD - Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, USA.
U2 - PMID: 18835680.
DO - 10.1016/j.jsat.2008.08.007
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Palmer, Catherine V.
AU - Solodar, Helena S.
AU - Hurley, Whitney R.
AU - Byrne, David C.
AU - Williams, Kadyn O.
T1 - Self-Perception of Hearing Ability as a Strong Predictor of Hearing Aid Purchase.
JO - Journal of the American Academy of Audiology
JF - Journal of the American Academy of Audiology
Y1 - 2009/06//
VL - 20
IS - 6
M3 - Article
SP - 341
EP - 347
SN - 10500545
AB - Background: Hearing threshold data are not particularly predictive of self-perceived hearing handicap or readiness to pursue amplification. Poor correlations between these measures have been reported repeatedly. When a patient is evaluated for hearing loss, it is common to collect both threshold data and the individual's self-perception of hearing ability. This is done to help the patient make an appropriate choice related to the pursuit of amplification or other communication strategies. It would be valuable, though, for the audiologist to be able to predict which patients are ready for amplification, which patients require more extensive counseling before pursuing amplification, and which patients simply are not ready for amplification regardless of the audiometric data. Purpose: The purpose of this study was to evaluate the following question for its potential usefulness as a determinant of patient readiness for amplification: "On a scale from 1 to 10, 1 being the worst and 10 being the best, how would you rate your overall hearing ability?" Research Design: The test-retest reliability and the predictive value of the question, based on final hearing aid purchase, were evaluated in a private practice setting. Study Sample: Eight hundred forty hearing-impaired adults in the age range from 18 to 95 years. Collection and Analysis: Data were collected retrospectively from patient files. Results and Conclusion: Results were repeatable and supported the use of this question in similar clinical settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Academy of Audiology is the property of American Academy of Audiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Self-perception
KW - Hearing
KW - Hearing aids
KW - Audiology -- Research
KW - Audiometry
KW - Patients
KW - hearing aid purchase
KW - self-perception
N1 - Accession Number: 43203995; Palmer, Catherine V. 1; Email Address: palmercv@upmc.edu; Solodar, Helena S.; Hurley, Whitney R. 1; Byrne, David C. 1,2; Williams, Kadyn O.; Affiliations: 1: University of Pittsburgh, Pittsburgh; 2: National Institute for Occupational Safety and Health, Cincinnati; Issue Info: Jun2009, Vol. 20 Issue 6, p341; Thesaurus Term: Self-perception; Thesaurus Term: Hearing; Thesaurus Term: Hearing aids; Thesaurus Term: Audiology -- Research; Thesaurus Term: Audiometry; Subject Term: Patients; Author-Supplied Keyword: hearing aid purchase; Author-Supplied Keyword: self-perception; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 7p; Illustrations: 4 Charts, 4 Graphs; Document Type: Article
L3 - 10.3766/jaaa.20.6.2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ufh&AN=43203995&site=ehost-live&scope=site
DP - EBSCOhost
DB - ufh
ER -
TY - JOUR
AU - Ghosh, Pulak
AU - Basu, Sanjib
AU - Tiwari, Ram C.
AD - GA State U
AD - Northern IL U
AD - US Food and Drug Administration, Silver Spring, MD
T1 - Bayesian Analysis of Cancer Rates from SEER Program Using Parametric and Semiparametric Joinpoint Regression Models
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/06//
VL - 104
IS - 486
SP - 439
EP - 452
SN - 01621459
N1 - Accession Number: 1137060; Publication Type: Journal Article; Update Code: 201011
N2 - Cancer is the second leading cause of death in the United States. Cancer incidence and mortality rates measure the progress against cancer; these rates are obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI). Lung cancer has the highest mortality rate among all cancers, whereas prostate cancer has the highest number of new cases among males. In this article, we analyze the incidence rates of these two cancers, as well as colon and rectal cancer. The NCI reports trends in cancer age-adjusted mortality and incidence rates in its annual report to the nation and analyzes them using the Joinpoint software. The location of the joinpoints signifies changes in cancer trends, whereas changes in the regression slope measure the degree of change. The Joinpoint software uses a numerical search to detect the joinpoints, fits regression within two consecutive joinpoints by least squares, and finally selects the number of joinpoints by either a series of permutation tests or the Bayesian information criterion. We propose Bayesian joinpoint models and provide statistical estimates of the joinpoints and the regression slopes. While the Joinpoint software and other work in this area assumes that the joinpoints occur on the discrete time grid, we allow a continuous prior for the joinpoints induced by the Dirichlet distribution on the spacings in between. This prior further allows the user to impose prespecified minimum gaps in between two consecutive joinpoints. We develop parametric as well as semiparametric Bayesian joinpoint models; the semiparametric framework relaxes parametric distributional assumptions by modeling the distribution of regression slopes and error variances using Dirichlet process mixtures. These Bayesian models provide statistical inference with finite sample validity. Through a simulation study, we demonstrate the performance of the proposed parametric and semiparametric joinpoint models and compare the results with the ones from the Joinpoint software. We analyze age-adjusted cancer incidence rates from the SEER Program using these Bayesian models with different numbers of joinpoints by employing the deviance information criterion and the cross-validated predictive criterion. In addition, we model the lung cancer incidence rates and the smoking rates jointly and explore the relation between the two longitudinal processes.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
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UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Norton, Jonathan D.
AU - Niu, Xu-Feng
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
AD - FL State U
T1 - Intrinsically Autoregressive Spatiotemporal Models with Application to Aggregated Birth Outcomes
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/06//
VL - 104
IS - 486
SP - 638
EP - 649
SN - 01621459
N1 - Accession Number: 1137075; Publication Type: Journal Article; Update Code: 201011
N2 - A class of hierarchical Bayesian models is proposed for adverse birth outcomes such as preterm birth, which are assumed to follow a conditional binomial distribution. The log-odds of an adverse outcome in a particular county, logit(p[subscript i]), follow a linear model that includes observed covariates and normally-distributed random effects. Spatial dependence between neighboring regions is allowed for by including an intrinsically autoregressive (IAR) prior or an IAR convolution prior in the linear predictor. Temporal dependence is incorporated by including a temporal IAR term also. It is shown that the variance parameters underlying these random effects (IAR, convolution, convolution plus temporal IAR) are identifiable. The Deviance Information Criterion (DIC) is considered as a way to compare spatial hierarchical models. Simulations are performed to test whether the DIC can identify whether binomial outcomes come from a hierarchical model that includes different combinations of random and fixed effects. Having validated the DIC as a means of comparing models, we examine preterm birth and low birth weight counts in the state of Arkansas from 1994-2005. We find that preterm birth and low birth weight have different spatial patterns of risk, and that rates of low birth weight can be fit with a relatively simple model that includes a constant spatial effect for all periods, a linear trend, and three covariates (multiple birth, black mother, smoking). It is also found that the risks of each outcome are increasing over time, even with adjustment for covariates.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
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UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Jie Tian
AU - Zhili Xu
AU - Smith, Jeffrey S.
AU - Hofherr, Sean E.
AU - Barry, Michael A.
AU - Byrnes, Andrew P.
T1 - Adenovirus Activates Complement by Distinctly Different Mechanisms In Vitro and In Vivo: Indirect Complement Activation by Virions In Vivo.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/06//
VL - 83
IS - 11
M3 - Article
SP - 5648
EP - 5658
SN - 0022538X
AB - Understanding innate immunity is key to improving the safety of adenovirus (Ad) vectors for systemic gene therapy. Ad has been shown to activate complement in vitro, but activation of complement after Ad injection in vivo has not been directly measured. Using complement protein C3a as a marker of complement activation, we show that types 2 and 5 human Ads cause rapid complement activation after intravenous injection in mice. Unexpectedly, the mechanisms in vivo were different than those in vitro. Antibodies were critical for the activation of complement by Ad in vitro, but antibodies were not required in vivo. The classical pathway was required in vitro, whereas complement activation in vivo involved both classical and nonclassical pathways as well as the reticuloendothelial system. Remarkably, the entry-deficient Ad mutant ts1 was completely unable to activate complement in vivo even though it was fully able to activate complement in vitro. This result demonstrates that the complement system senses intravenously injected Ad primarily by detecting the effects of Ad on cells rather than through direct interaction of complement with virions. Encouragingly, shielding Ad with polyethylene glycol was effective at reducing complement activation both in vitro and in vivo. In summary, intravenously injected Ad rapidly activates complement through multiple pathways, but these pathways are different than those identified by in vitro studies. In vitro studies are poorly predictive of in vivo mechanisms because Ad virions activate complement through indirect mechanisms in vivo. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - ENZYME activation
KW - NATURAL immunity
KW - GENE therapy
KW - POLYETHYLENE
KW - RETICULO-endothelial system
N1 - Accession Number: 40090294; Jie Tian 1 Zhili Xu 1 Smith, Jeffrey S. 1 Hofherr, Sean E. 2 Barry, Michael A. 2,3 Byrnes, Andrew P. 1; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 2: Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology Program, Mayo Clinic, Rochester, Minnesota 3: Department of Immunology and Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota; Source Info: Jun2009, Vol. 83 Issue 11, p5648; Subject Term: ADENOVIRUSES; Subject Term: ENZYME activation; Subject Term: NATURAL immunity; Subject Term: GENE therapy; Subject Term: POLYETHYLENE; Subject Term: RETICULO-endothelial system; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.00082-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40090294&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kase, Julie A.
AU - Correa, Maria T.
AU - Sobsey, Mark D.
T1 - Detection and molecular characterization of swine hepatitis E virus in North Carolina swine herds and their faecal wastes.
JO - Journal of Water & Health
JF - Journal of Water & Health
Y1 - 2009/06//
VL - 7
IS - 2
M3 - Article
SP - 344
EP - 357
SN - 14778920
AB - Recent findings of almost genetically indistinguishable swine and human strains, have suggested swine play a role in the transmission of hepatitis E virus (HEV). The extent to which HEV may be present and persist in the faecal waste generated from intensive swine operations is largely unknown. The fate of swine waste liquid is often land application, possibly resulting in unintentional seepage into groundwater or run-off into surface waters, hence validating concerns of human exposure risks. Freshly passed swine faeces, barn flush liquid waste, and lagoon liquid from production sites in North Carolina were surveyed periodically for HEV using RT-PCR primers located in ORF2. On three farms where HEV RNA was detected in swine faeces, it was also found in stored liquid waste on several occasions. HEV presence was related to swine age but not to animal management and waste management procedures, which varied amongst the farms. Seasonal patterns of HEV prevalence could not be established as viral RNA was isolated at all time points from two farms. Phylogenetic analysis of 212 bases of the genomic RNA indicated that isolates resembled the known US swine and human strains (percentage nucleic acid homology 91 to 94%), with one amino acid substitution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Water & Health is the property of IWA Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Swine -- Diseases
KW - Communicable diseases -- Transmission
KW - Viruses
KW - Nucleic acids
KW - Water supply
KW - Hepatitis E
KW - Feces
KW - North Carolina
KW - disease reservoirs
KW - faecal contamination
KW - hepatitis E virus
KW - public health
KW - water quality
KW - zoonoses
N1 - Accession Number: 42512789; Kase, Julie A. 1; Email Address: julieannkase@gmail.com; Correa, Maria T. 2; Sobsey, Mark D. 3; Affiliations: 1: Microbial Methods Development Branch Division of Microbiology, Office of Regulatory Sciences Center for Food Safety and Applied Nutrition, US Food and Drug Administration 5100, Paint Branch Parkway, Rm 3E-017, HFS-711, College Park, MD 20740, USA.; 2: Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, 4114A McGavran-Greenberg Hall, Chapel Hill, North Carolina 27599-7400, USA.; 3: Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.; Issue Info: Jun2009, Vol. 7 Issue 2, p344; Thesaurus Term: Swine -- Diseases; Thesaurus Term: Communicable diseases -- Transmission; Thesaurus Term: Viruses; Thesaurus Term: Nucleic acids; Thesaurus Term: Water supply; Subject Term: Hepatitis E; Subject Term: Feces; Subject: North Carolina; Author-Supplied Keyword: disease reservoirs; Author-Supplied Keyword: faecal contamination; Author-Supplied Keyword: hepatitis E virus; Author-Supplied Keyword: public health; Author-Supplied Keyword: water quality; Author-Supplied Keyword: zoonoses; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; Number of Pages: 14p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.2166/wh.2009.137
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=42512789&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Roberge, Raymond Joseph
T1 - Physiological Burden Associated with the Use of Filtering Facepiece Respirators (N95 Masks) during Pregnancy.
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
Y1 - 2009/06//
VL - 18
IS - 6
M3 - Article
SP - 819
EP - 826
PB - Mary Ann Liebert, Inc.
SN - 15409996
AB - Objective: The purpose of this study was to review the available literature regarding the physiological burden imposed on pregnant women by their wearing filtering facepiece respirators. Methods: A medical literature search was conducted using MEDLINE (1996–2008) for English language articles, bibliographies of retrieved articles, electronic references from medical and governmental agency sources, and selected textbook articles. Results: Two hundred thirty-four articles from the medical literature and 267 electronic references were retrieved, of which 51 articles from the medical literature, 25 electronic references, and 2 textbook articles were selected for data acquisition. Conclusions: Very little rigorous scientific data exist on the physiological burden associated with the use of filtering facepiece respirators by pregnant women, and no definitive conclusions can be reached at this time. Although studies are warranted, they may be difficult to undertake because of health concerns and potential liability associated with the use of pregnant women in medical research. Computer modeling that incorporates features of pulmonary function in pregnancy might offer an alternative to human studies. Filtering facepiece respirators developed to meet the respiratory limitations of pregnant wearers might offer a universal design that would improve the comfort and tolerability for all users. Alternative strategies that limit the pregnant woman's contact with potentially infectious agents (e.g., job reassignment, working from home) may have to be employed in certain circumstances. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Women's Health (15409996) is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health research
KW - MEDICAL literature
KW - PREGNANT women
KW - PATIENT monitoring
KW - RESPIRATORS (Medical equipment)
KW - MEDICINE -- Bibliographies
KW - ELECTRONIC reference sources
KW - GOVERNMENT agencies
KW - PULMONARY function tests
N1 - Accession Number: 41338183; Roberge, Raymond Joseph 1; Email Address: dtn0@cdc.gov; Affiliation: 1: National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania; Source Info: Jun2009, Vol. 18 Issue 6, p819; Subject Term: PUBLIC health research; Subject Term: MEDICAL literature; Subject Term: PREGNANT women; Subject Term: PATIENT monitoring; Subject Term: RESPIRATORS (Medical equipment); Subject Term: MEDICINE -- Bibliographies; Subject Term: ELECTRONIC reference sources; Subject Term: GOVERNMENT agencies; Subject Term: PULMONARY function tests; NAICS/Industry Codes: 911910 Other federal government public administration; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; NAICS/Industry Codes: 913910 Other local, municipal and regional public administration; NAICS/Industry Codes: 921190 Other General Government Support; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 8p; Illustrations: 4 Black and White Photographs; Document Type: Article
L3 - 10.1089/jwh.2008.1072
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41338183&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105355381
T1 - Physiological burden associated with the use of filtering facepiece respirators (N95 masks) during pregnancy.
AU - Roberge RJ
Y1 - 2009/06//
N1 - Accession Number: 105355381. Language: English. Entry Date: 20090724. Revision Date: 20150820. Publication Type: Journal Article; pictorial; review. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Obstetric Care; Women's Health. NLM UID: 101159262.
KW - Preventive Health Care -- In Pregnancy
KW - Respiratory Protective Devices
KW - Stress, Physiological
KW - Airway Resistance
KW - Computerized Literature Searching
KW - Female
KW - Medline
KW - Oxygenation
KW - Pregnancy
KW - Rhinitis
KW - United States Occupational Safety and Health Administration
SP - 819
EP - 826
JO - Journal of Women's Health (15409996)
JF - Journal of Women's Health (15409996)
JA - J WOMENS HEALTH (15409996)
VL - 18
IS - 6
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - OBJECTIVE: The purpose of this study was to review the available literature regarding the physiological burden imposed on pregnant women by their wearing filtering facepiece respirators. METHODS: A medical literature search was conducted using MEDLINE (1996-2008) for English language articles, bibliographies of retrieved articles, electronic references from medical and governmental agency sources, and selected textbook articles. RESULTS: Two hundred thirty-four articles from the medical literature and 267 electronic references were retrieved, of which 51 articles from the medical literature, 25 electronic references, and 2 textbook articles were selected for data acquisition. CONCLUSIONS: Very little rigorous scientific data exist on the physiological burden associated with the use of filtering facepiece respirators by pregnant women, and no definitive conclusions can be reached at this time. Although studies are warranted, they may be difficult to undertake because of health concerns and potential liability associated with the use of pregnant women in medical research. Computer modeling that incorporates features of pulmonary function in pregnancy might offer an alternative to human studies. Filtering facepiece respirators developed to meet the respiratory limitations of pregnant wearers might offer a universal design that would improve the comfort and tolerability for all users. Alternative strategies that limit the pregnant woman's contact with potentially infectious agents (e.g., job reassignment, working from home) may have to be employed in certain circumstances.
SN - 1540-9996
AD - National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health, Technology Research Branch, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA; dtn0@cdc.gov
U2 - PMID: 19514822.
DO - 10.1089/jwh.2008.1072
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105355381&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105540799
T1 - Sensitivity of household reported medical conditions in the medical expenditure panel survey.
AU - Machlin S
AU - Cohen J
AU - Elixhauser A
AU - Beauregard K
AU - Steiner C
Y1 - 2009/06//2009 Jun
N1 - Accession Number: 105540799. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Chronic Disease -- Economics
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Services Research -- Economics
KW - Adolescence
KW - Adult
KW - Aged
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Age
KW - Models, Statistical
KW - Pregnancy
KW - Sensitivity and Specificity
KW - Human
SP - 618
EP - 625
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - INTRODUCTION: Accurate survey data on medical conditions are critical for health care researchers. Although medical condition data are complex and are subject to reporting error, little information exists on the quality of household reported condition data. METHODS: We used pooled data from 4 years (2002-2005) of the Medical Expenditure Panel Survey (MEPS) to estimate the extent to which household respondents may underreport 23 types of medical conditions. The medical expenditure panel survey is a nationally representative annual survey of approximately 15,000 households which collects medical condition information in 2 separate components-the Household Component (HC) and the Medical Provider Component (MPC). We computed sensitivity rates based on linked HC and MPC data under the assumption that if collection of medical conditions from household respondents was complete, then the conditions reported in the MPC would also be reported in the HC. RESULTS: Sensitivity rates ranged from a high of 93.8% to a low of 37.4% and were 75% or higher for 10 of the 23 conditions analyzed. The overall sensitivity rate for the 23 conditions combined was 74%. CONCLUSIONS: Household reports tended to be more accurate for conditions that are highly salient, cause pain, require hospitalization, require ongoing treatment, have specific recognizable treatment, alter lifestyle, and/or affect daily life (eg, pregnancy, diabetes, and kidney stones). In addition, reporting generally was better when conditions are classified in broader categories rather than in more detail.
SN - 0025-7079
AD - Division of Statistical Research and Methods, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. steven.machlin@ahrq.hhs.gov
U2 - PMID: 19433993.
DO - 10.1097/MLR.0b013e318195fa79
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105540799&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Miura, Daishiro
AU - Dobrovolsky, Vasily N.
AU - Kimoto, Takafumi
AU - Kasahara, Yoshinori
AU - Heflich, Robert H.
T1 - Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2009/06//
VL - 677
IS - 1/2
M3 - Article
SP - 86
EP - 92
SN - 13835718
AB - Abstract: We previously reported the development of an in vivo gene mutation assay using the phosphatidylinositol glycan complementation group A gene (Pig-A) as an endogenous reporter. The assay quantifies mutation in rat peripheral red blood cells (RBCs) by flow cytometric detection of cells negative for glycosylphosphatidyl inositol (GPI)-anchored protein surface markers. In this study, we examined the accumulation and persistence of Pig-A mutant RBCs in rats treated with N-ethyl-N-nitrosourea (ENU) using two dosing schedules. Male F344 rats were given single i.p. injections of 8.9, 35.6, or 142.4mg/kg ENU or four equal weekly doses totaling 35.6 or 142.4mg/kg ENU (8.9mg/kg×4 or 35.6mg/kg×4; split-dose groups). Before the treatment and through 26 weeks after the single dose or beginning the split-dose regimen, peripheral RBCs were collected and Pig-A mutant frequencies measured as RBCs negative for the GPI-anchored protein, CD59. Mean CD59-negative RBC frequencies in negative control rats ranged from 3.9×10−6 to 28.7×10−6 and displayed no time-related trend. With single ENU doses, CD59-negative RBC frequencies increased in a time- and dose-related manner. Maximum responses were observed beginning at 6 weeks post-treatment (57.3×10−6 in the 8.9mg/kg group; 186.9×10−6 in the 35.6mg/kg group; 759.2×10−6 in the 142.4mg/kg group), and these elevated mutant frequencies persisted to the last sampling time. In addition, splitting the dose of ENU into four weekly doses produced nearly the same mutant frequency as when given as a single dose: the maximum responses after four weekly doses of 8.9 or 35.6mg/kg were 176.8×10−6 and 683.3×10−6, respectively. These results indicate that ENU-induced Pig-A mutant RBCs accumulate in a near additive fashion in rats, and once present in the peripheral blood, persist for at least 6 months. These characteristics of Pig-A mutation could be important for detecting weak mutagens by repeated or subchronic/chronic dosing protocols. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research/Genetic Toxicology & Environmental Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mutation (Biology)
KW - Bioaccumulation
KW - Biochemical markers
KW - Erythrocytes
KW - Rats as laboratory animals
KW - Nitrosoureas -- Therapeutic use
KW - Dosage of drugs
KW - Inositol -- Therapeutic use
KW - Proteins
KW - CD59
KW - Flow cytometry
KW - Gene mutation
KW - Glycosylphosphatidyl inositol
KW - N-Ethyl-N-nitrosourea
KW - Phosphatidylinositol glycan complementation group A gene
N1 - Accession Number: 43311495; Miura, Daishiro 1; Dobrovolsky, Vasily N. 2; Kimoto, Takafumi 1; Kasahara, Yoshinori 1; Heflich, Robert H. 2; Email Address: robert.heflich@fda.hhs.gov; Affiliations: 1: TEIJIN Pharma Limited, Tokyo, Japan; 2: Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States; Issue Info: Jun2009, Vol. 677 Issue 1/2, p86; Thesaurus Term: Mutation (Biology); Thesaurus Term: Bioaccumulation; Thesaurus Term: Biochemical markers; Subject Term: Erythrocytes; Subject Term: Rats as laboratory animals; Subject Term: Nitrosoureas -- Therapeutic use; Subject Term: Dosage of drugs; Subject Term: Inositol -- Therapeutic use; Subject Term: Proteins; Author-Supplied Keyword: CD59; Author-Supplied Keyword: Flow cytometry; Author-Supplied Keyword: Gene mutation; Author-Supplied Keyword: Glycosylphosphatidyl inositol; Author-Supplied Keyword: N-Ethyl-N-nitrosourea; Author-Supplied Keyword: Phosphatidylinositol glycan complementation group A gene; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrgentox.2009.05.014
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Mei, Nan
AU - Chen, Tao
AU - Godar, Dianne E.
AU - Moore, Martha M.
T1 - UVA-induced photomutagenicity of retinyl palmitate
JO - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
JF - Mutation Research/Genetic Toxicology & Environmental Mutagenesis
Y1 - 2009/06//
VL - 677
IS - 1/2
M3 - Letter
SP - 105
EP - 106
SN - 13835718
N1 - Accession Number: 43311498; Mei, Nan 1; Email Address: nan.mei@fda.hhs.gov; Chen, Tao 1; Godar, Dianne E. 2; Moore, Martha M. 1; Affiliations: 1: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; 2: Center for Devices and Radiological Health, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Issue Info: Jun2009, Vol. 677 Issue 1/2, p105; Number of Pages: 2p; Document Type: Letter
L3 - 10.1016/j.mrgentox.2009.05.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43311498&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Sahin, Leyla
AU - Feibus, Karen
AU - Buhimschi, Catalin S.
AU - Weiner, Carl P.
T1 - Medications in Pregnancy and Lactation.
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
Y1 - 2009/06//
VL - 113
IS - 6
M3 - Letter
SP - 1375
EP - 1376
SN - 00297844
AB - Several letters to the editor are presented in response to the article by Doctors Buhimschi and Weiner on the nature and importance of pregnancy registries in the characterization of the reproductive effects of a drug.
KW - LETTERS to the editor
KW - DRUGS -- Effectiveness
KW - EVALUATION
KW - REPRODUCTIVE health
KW - PREGNANCY
KW - OBSTETRICS
N1 - Accession Number: 41890589; Sahin, Leyla 1 Feibus, Karen 1 Buhimschi, Catalin S. 2 Weiner, Carl P. 3; Affiliation: 1: Maternal Health Team, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 2: Yale University School of Medicine, New Haven, Connecticut 3: University of Kansas, Kansas City, Kansas; Source Info: Jun2009, Vol. 113 Issue 6, p1375; Subject Term: LETTERS to the editor; Subject Term: DRUGS -- Effectiveness; Subject Term: EVALUATION; Subject Term: REPRODUCTIVE health; Subject Term: PREGNANCY; Subject Term: OBSTETRICS; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105536213
T1 - Medications in pregnancy and lactation...Obstet Gynecol. 2009 Jan;113(1):41-7
AU - Sahin L
AU - Feibus K
Y1 - 2009/06//
N1 - Accession Number: 105536213. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Obstetric Care; Women's Health. NLM UID: 0401101.
KW - Data Collection
KW - Lactation
KW - Pharmacy and Pharmacology
KW - Pregnancy -- Drug Effects
KW - Female
KW - Teratogens
SP - 1375
EP - 1376
JO - Obstetrics & Gynecology
JF - Obstetrics & Gynecology
JA - OBSTET GYNECOL
VL - 113
IS - 6
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0029-7844
AD - Maternal Health Team, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.
U2 - PMID: 19461450.
DO - 10.1097/AOG.0b013e3181a89486
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105165118
T1 - Treatment outcome and clinical findings of chronic ocular lymphangioma.
AU - Scarborough R
Y1 - 2009/06//
N1 - Accession Number: 105165118. Language: English. Entry Date: 20101008. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 100912421.
KW - Eye Neoplasms -- Surgery
KW - Lymphangioma -- Surgery
KW - Antiinflammatory Agents -- Therapeutic Use
KW - Eye Neoplasms -- Drug Therapy
KW - Eye Neoplasms -- Pathology
KW - Lymphangioma -- Drug Therapy
KW - Lymphangioma -- Pathology
KW - Male
KW - Recurrence
KW - Young Adult
SP - 322
EP - 323
JO - Optometry -- Journal of the American Optometric Association
JF - Optometry -- Journal of the American Optometric Association
JA - OPTOMETRY
VL - 80
IS - 6
CY - St. Louis, Missouri
PB - American Optometric Association
SN - 1529-1839
AD - Tsaile Health Center - Indian Health Service, Arizona.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105350684
T1 - Access to the medical home: new findings from the 2005-2006 National Survey of Children with Special Health Care Needs.
AU - Strickland BB
AU - Singh GK
AU - Kogan MD
AU - Mann MY
AU - van Dyck PC
AU - Newacheck PW
Y1 - 2009/06//
N1 - Accession Number: 105350684. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Child Health Services
KW - Child, Disabled
KW - Health Services Accessibility
KW - Adolescence
KW - Bivariate Statistics
KW - Chi Square Test
KW - Child
KW - Child, Preschool
KW - Confidence Intervals
KW - Data Analysis Software
KW - District of Columbia
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Interviews
KW - Male
KW - Odds Ratio
KW - Parents
KW - Questionnaires
KW - Human
SP - e996
EP - 1004
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 123
IS - 6
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - OBJECTIVE: This article reports new findings from the 2005-2006 National Survey of Children with Special Health Care Needs (NS-CSHCN) regarding parental perceptions of the extent to which children with special health care needs (CSHCN) have access to a medical home. METHODS: Five criteria were analyzed to describe the extent to which CSHCN receive care characteristic of the medical home concept. Data on 40840 children included in the NS-CSHCN were used to assess the presence of a medical home, as indicated by achieving each of the 5 criteria. RESULTS: Results of the survey indicate that (1) approximately one half of CSHCN receive care that meets all 5 criteria established for a medical home; (2) access to a medical home is affected significantly by race/ethnicity, income, health insurance status, and severity of the child's condition; (3) parents of children who do have a medical home report significantly less delayed or forgone care and significantly fewer unmet needs for health care and family support services; and (4) limited improvements have occurred since success rates were first measured by using the 2001 NS-CSHCN. CONCLUSIONS: The findings suggest that, although some components of the medical home concept have been achieved for most CSHCN, care synonymous with the principles underlying the medical home is not yet in place for a significant number of CSHCN and their families.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Parklawn Building 188-A-27, 5600 Fishers Lane, Rockville, MD 20857, USA. bstrickland@hrsa.gov
U2 - PMID: 19482751.
DO - 10.1542/peds.2008-2504
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Suneela Prodduturi
AU - Glen Smith
AU - Anna Wokovich
AU - William Doub
AU - Benjamin Westenberger
AU - Lucinda Buhse
T1 - Reservoir Based Fentanyl Transdermal Drug Delivery Systems: Effect of Patch Age on Drug Release and Skin Permeation.
JO - Pharmaceutical Research
JF - Pharmaceutical Research
Y1 - 2009/06//
VL - 26
IS - 6
M3 - Article
SP - 1344
EP - 1352
SN - 07248741
AB - Abstract Purpose To understand and evaluate the stability and skin permeation profiles of fentanyl reservoir systems as a function of patch age. Methods Drug release and skin permeation studies were performed using a modified USP apparatus 5 with a novel sample preparation technique. Results The amount of fentanyl present in the EVA/adhesive layer (EAL) increased from about 17% of label claim (LC) at 5 months to 25% LC at 22 months. The increase in the drug concentration was mainly observed in the peripheral EAL. Simultaneously, the alcohol content of the patch decreased as a function of patch age. A significant effect of patch age on the drug content in the EAL and the drug release from the system was observed; however, skin permeation studies did not indicate an increase in drug delivery rate. Conclusions Novel sample preparation technique with USP Apparatus 5 allowed determination of in vitro skin permeation rates for fentanyl transdermal patches with different designs. Permeation rates with cadaver skin as substrate were found not to change with patch age despite changing drug concentration in the EAL. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSDERMAL medication
KW - FENTANYL
KW - SKIN -- Permeability
KW - STABILITY (Mechanics)
KW - BIOADHESIVE drug delivery systems
KW - DRUGS -- Solubility -- Testing
KW - DRUGS -- Controlled release
N1 - Accession Number: 39058570; Suneela Prodduturi 1 Glen Smith 2 Anna Wokovich 1 William Doub 1 Benjamin Westenberger 1 Lucinda Buhse 1; Affiliation: 1: U.S. Food and Drug Administration Division of Pharmaceutical Analysis 1114 Market St. Rm 1002 St. Louis Missouri 63101 USA 2: U.S. Food and Drug Administration Office of Generic Drugs Rockville Maryland USA; Source Info: Jun2009, Vol. 26 Issue 6, p1344; Subject Term: TRANSDERMAL medication; Subject Term: FENTANYL; Subject Term: SKIN -- Permeability; Subject Term: STABILITY (Mechanics); Subject Term: BIOADHESIVE drug delivery systems; Subject Term: DRUGS -- Solubility -- Testing; Subject Term: DRUGS -- Controlled release; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, John
AU - Moore, Christine
AU - Nasr, Moheb
T1 - Quality Trio Takes Final Shape.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2009/06//
VL - 33
IS - 6
M3 - Article
SP - 66
EP - 66
SN - 15432521
AB - The article offers information about the three quality guidelines of the International Conference on Harmonization (ICH) for the pharmaceutical industry. It relates that the guidances, which are intended for pharmaceutical development (Q8), quality risk management (Q9) and pharmaceutical quality system (Q10), provide clarifications needed to ensure harmonized approach to the implementation of quality by design (QbD). The purpose and directives of each of the guidelines are discussed.
KW - RISK management in business
KW - PHARMACEUTICAL industry
KW - PHARMACEUTICAL services
KW - GUIDELINES
KW - DRUG development
KW - QUALITY
KW - INTERNATIONAL organization
N1 - Accession Number: 42122407; Smith, John 1; Moore, Christine 1; Nasr, Moheb 1; Affiliations: 1: Office of New Drug Quality Assessment in FDA's Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Bldg. 21, Rm. 2630, Silver Spring, MD 20993-0002; Issue Info: Jun2009, Vol. 33 Issue 6, p66; Thesaurus Term: RISK management in business; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: PHARMACEUTICAL services; Subject Term: GUIDELINES; Subject Term: DRUG development; Subject Term: QUALITY; Subject Term: INTERNATIONAL organization; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Rue-Cover, Alison
AU - Iskander, John
AU - Lyn, Shauna
AU - Burwen, Dale R.
AU - Gargiullo, Paul
AU - Shadomy, Sean
AU - Blostein, Joel
AU - Bridges, Carolyn B.
AU - Haber, Penina
AU - Satzger, R. Duane
AU - Ball, Robert
AU - Seward, Jane F.
T1 - Death and serious illness following influenza vaccination: a multidisciplinary investigation.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/06//
VL - 18
IS - 6
M3 - Article
SP - 504
EP - 511
SN - 10538569
AB - Purpose To evaluate a possible association between influenza vaccination and four deaths and four serious illnesses among 114 recent influenza vaccinees in a long-term care facility (LTCF) and two deaths from a nearby physician's office. All had received vaccine from the same lot (Lot A). Methods Field investigation including (1) a retrospective cohort study among LTCF residents who received Lot A or other influenza vaccine, (2) review of medical records of cases of death or serious illness, (3) active surveillance of deaths among 1500 community based Lot A vaccinees and (4) laboratory testing of vaccine from available Lot A vials. Results Medical record reviews showed no common clinical syndrome or cause of death. Laboratory testing of Lot A samples revealed no evidence of tampering and no differences compared to an unrelated lot. The risk of death or hospitalization was not significantly different between persons who received Lot A versus a comparison lot, Lot B (incidence rate ratio (IRR) = 0.9, 95%CI = 0.3-3.3). Conclusions There was no clinical or biological evidence pointing to inherent vaccine safety issues, nor was there a detectable increased risk of death or hospitalization among persons vaccinated with Lot A. Lot specific clustering of adverse events (AEs) may reflect medical events causally unrelated to vaccination. Rapid investigations of potential AEs are important to ensure vaccine safety and to maintain public and healthcare provider confidence in vaccines. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707182; Rue-Cover, Alison 1,2; Iskander, John 3; Lyn, Shauna 2; Burwen, Dale R. 4; Gargiullo, Paul 1; Shadomy, Sean 3; Blostein, Joel 5; Bridges, Carolyn B. 1; Haber, Penina 3; Satzger, R. Duane 6; Ball, Robert 4; Seward, Jane F. 1; Affiliations: 1: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; 2: Epidemic Intelligence Service Officer, Centers for Disease Control and Prevention, Atlanta, GA, USA; 3: Immunization Safety Office (ISO), Division of Healthcare Quality Promotion (proposed), Centers for Disease Control and Prevention, Atlanta, GA, USA; 4: Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Rockville, MA, USA; 5: Michigan Department of Community Health (MDCH), Lansing, MI, USA; 6: Office of Regulatory Affairs (ORA), Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH, USA; Issue Info: Jun2009, Vol. 18 Issue 6, p504; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/pds.1743
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ursem, Carling J.
AU - Kruhlak, Naomi L.
AU - Contrera, Joseph F.
AU - MacLaughlin, Philip M.
AU - Benz, R. Daniel
AU - Matthews, Edwin J.
T1 - Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2009/06//
VL - 54
IS - 1
M3 - Article
SP - 1
EP - 22
SN - 02732300
AB - Abstract: The Informatics and Computational Safety Analysis Staff at the US FDA’s Center for Drug Evaluation and Research has created a database of pharmaceutical adverse effects (AEs) linked to pharmaceutical chemical structures and estimated population exposures. The database is being used to develop quantitative structure–activity relationship (QSAR) models for the prediction of drug-induced liver and renal injury, as well as to identify relationships among AEs. The post-market observations contained in the database were obtained from FDA’s Spontaneous Reporting System (SRS) and the Adverse Event Reporting System (AERS) accessed through Elsevier PharmaPendium™ software. The database contains approximately 3100 unique pharmaceutical compounds and 9685 AE endpoints. To account for variations in AE reports due to different patient populations and exposures for each drug, a proportional reporting ratio (PRR) was used. The PRR was applied to all AEs to identify chemicals that could be scored as positive in the training data sets of QSAR models. Additionally, toxicologically similar AEs were grouped into clusters based upon both biological effects and statistical correlation. This clustering created a weight of evidence paradigm for the identification of compounds most likely to cause human harm based upon findings in multiple related AE endpoints. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Toxicity testing
KW - QSAR (Biochemistry)
KW - Drugs
KW - EFFECTIVENESS
KW - Biliary tract
KW - AERS
KW - Drug-induced kidney toxicity
KW - Drug-induced liver toxicity
KW - Human adverse effects
KW - Post-market reporting
KW - QSAR
KW - Quantitative structure–activity relationships
KW - SRS
N1 - Accession Number: 38800163; Ursem, Carling J. 1,2; Kruhlak, Naomi L. 1; Contrera, Joseph F. 3; MacLaughlin, Philip M. 4; Benz, R. Daniel 1; Matthews, Edwin J. 1; Email Address: Edwin.Matthews@fda.hhs.gov; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA; 2: GlobalNet Services, 11820 Parklawn Drive, Rockville, MD 20852, USA; 3: Computational Toxicology Services LLC, PO Box 1565, Olney, MD 20830, USA; 4: Elsevier, 15 Belleau Road, Salem, MA 01970, USA; Issue Info: Jun2009, Vol. 54 Issue 1, p1; Thesaurus Term: RESEARCH; Thesaurus Term: Toxicity testing; Thesaurus Term: QSAR (Biochemistry); Subject Term: Drugs; Subject Term: EFFECTIVENESS; Subject Term: Biliary tract; Author-Supplied Keyword: AERS; Author-Supplied Keyword: Drug-induced kidney toxicity; Author-Supplied Keyword: Drug-induced liver toxicity; Author-Supplied Keyword: Human adverse effects; Author-Supplied Keyword: Post-market reporting; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Quantitative structure–activity relationships; Author-Supplied Keyword: SRS; Number of Pages: 22p; Document Type: Article
L3 - 10.1016/j.yrtph.2008.12.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Ursem, Carling J.
AU - Kruhlak, Naomi L.
AU - Benz, R. Daniel
AU - Sabaté, David Aragonés
AU - Yang, Chihae
AU - Klopman, Gilles
AU - Contrera, Joseph F.
T1 - Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2009/06//
VL - 54
IS - 1
M3 - Article
SP - 23
EP - 42
SN - 02732300
AB - Abstract: This report describes the development of quantitative structure-activity relationship (QSAR) models for predicting rare drug-induced liver and urinary tract injury in humans based upon a database of post-marketing adverse effects (AEs) linked to ∼1600 chemical structures. The models are based upon estimated population exposure using AE proportional reporting ratios. Models were constructed for 5 types of liver injury (liver enzyme disorders, cytotoxic injury, cholestasis and jaundice, bile duct disorders, gall bladder disorders) and 6 types of urinary tract injury (acute renal disorders, nephropathies, bladder disorders, kidney function tests, blood in urine, urolithiases). Identical training data sets were configured for 4 QSAR programs (MC4PC, MDL-QSAR, BioEpisteme, and Predictive Data Miner). Model performance was optimized and was shown to be affected by the AE scoring method and the ratio of the number of active to inactive drugs. The best QSAR models exhibited an overall average 92.4% coverage, 86.5% specificity and 39.3% sensitivity. The 4 QSAR programs were demonstrated to be complementary and enhanced performance was obtained by combining predictions from 2 programs (average 78.4% specificity, 56.2% sensitivity). Consensus predictions resulted in better performance as judged by both internal and external validation experiments. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Structure-activity relationships (Biochemistry)
KW - Toxicology
KW - Nephrotoxicology
KW - Drugs -- Effectiveness
KW - AERS
KW - Computational toxicology
KW - Drug adverse effects
KW - Drug-induced liver injury
KW - Drug-induced renal toxicity
KW - In silico
KW - Post-market reporting
KW - QSAR software
KW - Quantitative structure-activity relationships
KW - SAR
KW - SRS
N1 - Accession Number: 38800164; Matthews, Edwin J. 1; Email Address: edwin.matthews@fda.hhs.gov; Ursem, Carling J. 1,2; Kruhlak, Naomi L. 1; Benz, R. Daniel 1; Sabaté, David Aragonés 3; Yang, Chihae 4; Klopman, Gilles 5; Contrera, Joseph F. 6; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Ave., Silver Spring, MD 20993, USA; 2: GlobalNet Services, 11820 Parklawn Drive, Rockville, MD 20852, USA; 3: Prous Institute for Biomedical Research, S.A., Provenza 388, 08025 Barcelona, Spain; 4: Leadscope, Inc., 1393 Dublin Road, Columbus, OH 43215, USA; 5: Multicase, Inc., Ste 305, 23811 Chagrin Blvd., Beachwood, OH 44122, USA; 6: Computational Toxicology Services LLC, P.O. Box 1565, Olney, MD 20830, USA; Issue Info: Jun2009, Vol. 54 Issue 1, p23; Thesaurus Term: Structure-activity relationships (Biochemistry); Thesaurus Term: Toxicology; Subject Term: Nephrotoxicology; Subject Term: Drugs -- Effectiveness; Author-Supplied Keyword: AERS; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Drug adverse effects; Author-Supplied Keyword: Drug-induced liver injury; Author-Supplied Keyword: Drug-induced renal toxicity; Author-Supplied Keyword: In silico; Author-Supplied Keyword: Post-market reporting; Author-Supplied Keyword: QSAR software; Author-Supplied Keyword: Quantitative structure-activity relationships; Author-Supplied Keyword: SAR; Author-Supplied Keyword: SRS; Number of Pages: 20p; Document Type: Article
L3 - 10.1016/j.yrtph.2009.01.009
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Matthews, Edwin J.
AU - Kruhlak, Naomi L.
AU - Daniel Benz, R.
AU - Sabaté, David Aragonés
AU - Marchant, Carol A.
AU - Contrera, Joseph F.
T1 - Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2009/06//
VL - 54
IS - 1
M3 - Article
SP - 43
EP - 65
SN - 02732300
AB - Abstract: This report describes an in silico methodology to predict off-target pharmacologic activities and plausible mechanisms of action (MOAs) associated with serious and unexpected hepatobiliary and urinary tract adverse effects in human patients. The investigation used a database of 8,316,673 adverse event (AE) reports observed after drugs had been marketed and AEs noted in the published literature that were linked to 2124 chemical structures and 1851 approved clinical indications. The Integrity™ database of drug patent and literature studies was used to find pharmacologic targets and proposed clinical indications. BioEpisteme™ QSAR software was used to predict possible molecular targets of drug molecules and Derek™ for Windows expert system software to predict chemical structural alerts and plausible MOAs for the AEs. AEs were clustered into five types of liver injury: liver enzyme disorders, cytotoxic injury, cholestasis and jaundice, bile duct disorders, and gall bladder disorders, and six types of urinary tract injury: acute renal disorders, nephropathies, bladder disorders, kidney function tests, blood in urine, and urolithiasis. Results showed that drug-related AEs were highly correlated with: (1) known drug class warnings, (2) predicted off-target activities of the drugs, and (3) a specific subset of clinical indications for which the drug may or may not have been prescribed. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Structure-activity relationships (Biochemistry)
KW - Toxicology
KW - Antineoplastic agents
KW - Drugs -- Physiological effect
KW - Adverse drug effects
KW - AERS
KW - Clinical indication
KW - Computational toxicology
KW - Drug-induced kidney toxicity
KW - Drug-induced liver toxicity
KW - In silico
KW - Mechanism of action
KW - Pharmaceutical patent
KW - Post-market reporting
KW - QSAR
KW - Quantitative structure–activity relationships
KW - SAR
KW - SRS
N1 - Accession Number: 38800165; Matthews, Edwin J. 1; Email Address: Edwin.Matthews@fda.hhs.gov; Kruhlak, Naomi L. 1; Daniel Benz, R. 1; Sabaté, David Aragonés 2; Marchant, Carol A. 3; Contrera, Joseph F. 4; Affiliations: 1: US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA; 2: Prous Institute for Biomedical Research, S.A., Provenza 388, 08025 - Barcelona, Spain; 3: Lhasa Limited, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD, UK; 4: Computational Toxicology Services LLC, P.O. Box 1565, Olney, MD 20830, USA; Issue Info: Jun2009, Vol. 54 Issue 1, p43; Thesaurus Term: Structure-activity relationships (Biochemistry); Thesaurus Term: Toxicology; Subject Term: Antineoplastic agents; Subject Term: Drugs -- Physiological effect; Author-Supplied Keyword: Adverse drug effects; Author-Supplied Keyword: AERS; Author-Supplied Keyword: Clinical indication; Author-Supplied Keyword: Computational toxicology; Author-Supplied Keyword: Drug-induced kidney toxicity; Author-Supplied Keyword: Drug-induced liver toxicity; Author-Supplied Keyword: In silico; Author-Supplied Keyword: Mechanism of action; Author-Supplied Keyword: Pharmaceutical patent; Author-Supplied Keyword: Post-market reporting; Author-Supplied Keyword: QSAR; Author-Supplied Keyword: Quantitative structure–activity relationships; Author-Supplied Keyword: SAR; Author-Supplied Keyword: SRS; Number of Pages: 23p; Document Type: Article
L3 - 10.1016/j.yrtph.2009.01.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=38800165&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Peden-Adams, Margie M.
AU - Stuckey, Joyce E.
AU - Gaworecki, Kristen M.
AU - Berger-Ritchie, Jennifer
AU - Bryant, Kathy
AU - Jodice, Patrick G.
AU - Scott, Thomas R.
AU - Ferrario, Joseph B.
AU - Guan, Bing
AU - Vigo, Craig
AU - Boone, J. Scott
AU - McGuinn, W. David
AU - DeWitt, Jamie C.
AU - Keil, Deborah E.
T1 - Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS)
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2009/06//
VL - 27
IS - 3/4
M3 - Article
SP - 307
EP - 318
SN - 08906238
AB - Abstract: Studies show that perfluorinated compounds cause various toxicological effects; nevertheless, effects on immune function and developmental endpoints have not been addressed at length. This study examined the effects of perfluorooctane sulfonate (PFOS) in white leghorn hatchlings on various developmental, immunological, and clinical health parameters. In addition, serum PFOS concentrations were determined by LC/MS/MS. Embryonic day (ED) 0 eggs were injected with either safflower oil/10% DMSO (control, 0mg/kg egg wt) or PFOS in safflower oil/10% DMSO at 1, 2.5, or 5mg/kg egg wt, and the chicks were grown to post-hatch day (PHD) 14. Treatment with PFOS did not affect hatch rate. Following in ovo exposure chicks exhibited increases in spleen mass at all treatment levels, in liver mass at 2.5 and 5mg/kg egg wt, and in body length (crown-rump length) at the 5mg/kg treatment. Right wings were shorter in all treatments compared to control. Increases in the frequency of brain asymmetry were evident in all treatment groups. SRBC-specific immunoglobulin (IgM and IgY combined) titers were decreased significantly at all treatment levels, while plasma lysozyme activity was increased at all treatment levels. The PHA skin test response decreased in relation to increasing PFOS dose. Serum concentrations where significant immunological, morphological, and neurological effects were observed at the lowest dose (1mg/kg egg wt) averaged 154ng PFOS/g serum. These concentrations fall within environmental ranges reported in blood samples from wild caught avian species; thereby, verifying that the environmental egg concentrations used for the injections do indeed relate to serum levels in hatchlings that are also environmentally relevant. These data indicate that immune alterations and brain asymmetry can occur in birds following in ovo exposure to environmentally relevant concentrations of PFOS and demonstrates the need for further research on the developmental effects of perfluorinated compounds in various species. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - CHICKENS
KW - IMMUNOLOGY
KW - SERUM
KW - ALT
KW - Bird
KW - Brain asymmetry
KW - Cholesterol
KW - Developmental
KW - Embryonic
KW - Immune
KW - In ovo
KW - PFOS
N1 - Accession Number: 38319883; Peden-Adams, Margie M. 1,2,3; Email Address: pedenadams@gmail.com Stuckey, Joyce E. 3 Gaworecki, Kristen M. 4 Berger-Ritchie, Jennifer 5 Bryant, Kathy 4 Jodice, Patrick G. 6 Scott, Thomas R. 7 Ferrario, Joseph B. 8 Guan, Bing 8 Vigo, Craig 8 Boone, J. Scott 8 McGuinn, W. David 9 DeWitt, Jamie C. 10 Keil, Deborah E. 5; Affiliation: 1: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA 2: Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, SC, USA 3: Grice Marine Laboratory, College of Charleston, Charleston, SC, USA 4: Institute of Environmental Toxicology, Clemson University, Pendleton, SC, USA 5: Clinical Laboratory Sciences, University of Nevada, Las Vegas, NV, USA 6: U.S. Geological Survey, South Carolina Cooperative Fish and Wildlife Research Unit and Department of Forestry and Natural Resources, Clemson University, Clemson, SC, USA 7: Department of Animal and Veterinary Science, Clemson University, Clemson, SC, USA 8: United States Environmental Protection Agency/OPP/BEAD/Environmental Chemistry Lab, John C. Stennis Space Center, MS, USA 9: United States Food and Drug Administration, Silver Spring, MD, USA 10: East Carolina University, Department of Pharmacology and Toxicology, The Brody School of Medicine, Greenville, NC, USA; Source Info: Jun2009, Vol. 27 Issue 3/4, p307; Subject Term: TOXICOLOGY; Subject Term: CHICKENS; Subject Term: IMMUNOLOGY; Subject Term: SERUM; Author-Supplied Keyword: ALT; Author-Supplied Keyword: Bird; Author-Supplied Keyword: Brain asymmetry; Author-Supplied Keyword: Cholesterol; Author-Supplied Keyword: Developmental; Author-Supplied Keyword: Embryonic; Author-Supplied Keyword: Immune; Author-Supplied Keyword: In ovo; Author-Supplied Keyword: PFOS; NAICS/Industry Codes: 112310 Chicken Egg Production; NAICS/Industry Codes: 112340 Poultry Hatcheries; NAICS/Industry Codes: 311615 Poultry Processing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.reprotox.2008.10.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38319883&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dukers-Muijrers, N. H. T. M.
AU - Niekamp, A-M.
AU - Vergoossen, M. M. H.
AU - Hoebe, C. J. P. A.
T1 - Effectiveness of an opting-out strategy for HIV testing: evaluation of 4 years of standard HIV testing in a STI clinic.
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
Y1 - 2009/06//
VL - 85
IS - 3
M3 - Article
SP - 226
EP - 230
SN - 13684973
AB - Objectives: A high proportion of individuals infected with HIV are unaware of the infection. They miss the opportunity for timely treatment. Our sexually transmitted infection (STI) clinic (South Limburg, The Netherlands) recognised the need to increase test rates and from 2004 routinely includes a HIV test, unless the client refuses, in each consultation. We evaluated the effectiveness of this opting-out approach for HIV testing. Methods: We used anonymised data from our STI clinic from 2003-2007 to assess trends in HIV testing and (reasons for) test refusal using multivariate analyses and interview. Laboratory registry data from the area that is served by the clinic were evaluated as well. Results: In South Limburg the number of HIV tests increased, which was mostly due to increasing STI clinic requests and antenatal screening. Of STI clinic attendees, 84% (1616/1920) were tested in 2003 and this proportion increased to 96% (3699/3836) in 2007. However, 88% (n = 57/65) of men who have sex with men and 44% (191/424) of heterosexuals who refused HIV testing after 2004 were linked to higher STI/HIV risk. Our clinic now uses these findings to develop more effective and tailored HIV/STI counselling in order to further optimise HIV testing practice. Conclusions: Standard testing on HIV in a STI clinic is feasible and effective in increasing awareness of one's HIV status. It should be an essential part of STI screening in STI clinics and should be considered in other healthcare settings for specific risk groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sexually Transmitted Infections is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - HIV-positive persons
KW - SEXUALLY transmitted diseases
KW - DIAGNOSIS
KW - HEALTH facilities
KW - NETHERLANDS
N1 - Accession Number: 42987867; Dukers-Muijrers, N. H. T. M. 1,2; Email Address: nicole.dukers@ggdzl.nl Niekamp, A-M. 1,2 Vergoossen, M. M. H. 1 Hoebe, C. J. P. A. 1,2; Affiliation: 1: Department of Infectious Diseases, South Limburg Public Health Service, Geleen, The Netherlands 2: Maastricht Infection Centre, Maastricht University Medical Centre, Maastricht, The Netherlands; Source Info: Jun2009, Vol. 85 Issue 3, p226; Subject Term: HEALTH risk assessment; Subject Term: HIV-positive persons; Subject Term: SEXUALLY transmitted diseases; Subject Term: DIAGNOSIS; Subject Term: HEALTH facilities; Subject Term: NETHERLANDS; NAICS/Industry Codes: 621498 All Other Outpatient Care Centers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42987867&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Starlard-Davenport, Athena
AU - Lyn-Cook, Beverly
AU - Radominska-Pandya, Anna
T1 - Erratum to “Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues” [Steroids 73 (6) (2008) 611–620]
JO - Steroids
JF - Steroids
Y1 - 2009/06//
VL - 74
IS - 6
M3 - Correction notice
SP - 548
EP - 549
SN - 0039128X
N1 - Accession Number: 37161067; Starlard-Davenport, Athena 1 Lyn-Cook, Beverly 2 Radominska-Pandya, Anna 1; Email Address: radominskaanna@uams.edu; Affiliation: 1: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 516, Little Rock, AR 72205, USA 2: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, HFT-100 Jefferson, AR 72079, USA; Source Info: Jun2009, Vol. 74 Issue 6, p548; Number of Pages: 2p; Document Type: Correction notice
L3 - 10.1016/j.steroids.2008.01.019
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=37161067&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105392795
T1 - Investigation of whether the acute hemolysis associated with Rh(o)(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model.
AU - Gaines AR
AU - Lee-Stroka H
AU - Byrne K
AU - Scott DE
AU - Uhl L
AU - Lazarus E
AU - Stroncek DF
AU - Gaines, Ann Reed
AU - Lee-Stroka, Hallie
AU - Byrne, Karen
AU - Scott, Dorothy E
AU - Uhl, Lynne
AU - Lazarus, Ellen
AU - Stroncek, David F
Y1 - 2009/06//
N1 - Accession Number: 105392795. Language: English. Entry Date: 20090821. Revision Date: 20161119. Publication Type: journal article; case study; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. Grant Information: ZIA CL002119-04//Intramural NIH HHS/United States. NLM UID: 0417360.
KW - Anemia, Hemolytic -- Etiology
KW - Purpura, Thrombocytopenic -- Therapy
KW - Rho(D) Immune Globulin -- Adverse Effects
KW - Acute Disease
KW - Erythrocytes -- Immunology
KW - Female
KW - Hemolysis
KW - Middle Age
KW - Human
SP - 1050
EP - 1058
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background: Immune thrombocytopenic purpura and secondary thrombocytopenia patients treated with Rh(o)(D) immune globulin intravenous (human; anti-D IGIV) have experienced acute hemolysis, which is inconsistent with the typical presentation of extravascular hemolysis -- the presumed mechanism of action of anti-D IGIV. Although the mechanism of anti-D-IGIV-associated acute hemolysis has not been established, the onset, signs/symptoms, and complications appear consistent with the intravascular hemolysis of acute hemolytic transfusion reactions (AHTRs). In transfusion medicine, the red blood cell (RBC) antigen-antibody incompatibility(-ies) that precipitate AHTRs can be detected in vitro with compatibility testing. Under the premise that anti-D-IGIV-associated acute hemolysis results from RBC antigen-antibody-mediated complement activation, this study evaluated whether the incompatibility(-ies) could be detected in vitro with a hemolysin assay, which would support the AHTR model as the hemolytic mechanism.Study Design and Methods: Seven anti-D IGIV lots were tested to determine the RBC antibody identities in those lots, including four lots that had been implicated in acute hemolytic episodes. Hemolysin assays were performed that tested each of 73 RBC specimens against each lot, including the RBCs of one patient who had experienced acute hemolysis after anti-D IGIV administration.Results: Only two anti-D IGIV lots contained RBC antibodies beyond those expected. No hemolysis endpoint was observed in any of the hemolysin assays.Conclusion: Although the findings did not support the AHTR model, the results are reported to contribute knowledge about the mechanism of anti-D-IGIV-associated acute hemolysis and to prompt continued investigation into cause(s), prediction, and prevention of this potentially serious adverse event.
SN - 0041-1132
AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. ann.gaines@fda.hhs.gov
U2 - PMID: 19220820.
DO - 10.1111/j.1537-2995.2008.02083.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105392795&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105392811
T1 - Quantitative estimate of the risks and benefits of possible alternative blood donor deferral strategies for men who have had sex with men.
AU - Anderson SA
AU - Yang H
AU - Gallagher LM
AU - O'Callaghan S
AU - Forshee RA
AU - Busch MP
AU - McKenna MT
AU - Williams I
AU - Williams A
AU - Kuehnert MJ
AU - Stramer S
AU - Kleinman S
AU - Epstein J
AU - Dayton AI
Y1 - 2009/06//
N1 - Accession Number: 105392811. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Blood Donors
KW - HIV Infections -- Prevention and Control
KW - Homosexuality
KW - Sexuality
KW - Adolescence
KW - Adult
KW - Aged
KW - Hepatitis B -- Prevention and Control
KW - Hepatitis B -- Transmission
KW - HIV Infections -- Transmission
KW - Male
KW - Middle Age
KW - Quarantine
SP - 1102
EP - 1114
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD 20852-1448, USA.
U2 - PMID: 19320868.
DO - 10.1111/j.1537-2995.2009.02124.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105392811&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105392806
T1 - Blood use in the ambulatory setting among elderly in the United States.
AU - Menis M
AU - Burwen DR
AU - Holness L
AU - Anderson SA
Y1 - 2009/06//
N1 - Accession Number: 105392806. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Ambulatory Care -- Statistics and Numerical Data
KW - Blood Transfusion -- Statistics and Numerical Data
KW - Aged
KW - Aged, 80 and Over
KW - Cross Sectional Studies
KW - Female
KW - Male
KW - United States
KW - Human
SP - 1186
EP - 1194
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. Mikhail.Menis@fda.hhs.gov
U2 - PMID: 19309470.
DO - 10.1111/j.1537-2995.2009.02114.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105392806&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-05792-005
AN - 2009-05792-005
AU - Violanti, John M.
AU - Fekedulegn, Desta
AU - Charles, Luenda E.
AU - Andrew, Michael E.
AU - Hartley, Tara A.
AU - Mnatsakanova, Anna
AU - Burchfiel, Cecil M.
T1 - Suicide in police work: Exploring potential contributing influences.
JF - American Journal of Criminal Justice
JO - American Journal of Criminal Justice
JA - Am J Crim Justice
Y1 - 2009/06//
VL - 34
IS - 1-2
SP - 41
EP - 53
CY - Germany
PB - Springer
SN - 1066-2316
SN - 1936-1351
AD - Violanti, John M., Department of Social & Preventive Medicine, School of Public Health & Health Professions, State University of NY at Buffalo, 270 Farber Hall, Buffalo, NY, US, 14214
N1 - Accession Number: 2009-05792-005. Partial author list: First Author & Affiliation: Violanti, John M.; Department of Social & Preventive Medicine, School of Public Health & Health Professions, State University of NY at Buffalo, Buffalo, NY, US. Other Publishers: Southern Criminal Justice Assn. Release Date: 20090720. Correction Date: 20090803. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Demographic Characteristics; Police Personnel; Risk Factors; Suicidal Ideation. Minor Descriptor: Suicide. Classification: Police & Legal Personnel (4290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Jun, 2009.
AB - Police officers are considered at increased risk for suicide. The objective of this study was to explore potential influences on suicide ideation among 105 randomly selected men and women urban police officers. Depression, gender, and marital status appeared to be most strongly associated with police suicidal ideation. Depressive symptoms were higher among women than men officers (12.5 percent vs. 6.2 percent). For each standard deviation increase in depressive symptoms, the prevalence ratio (PR) of suicide ideation increased 73 percent in women (PR = 1.73, 95% CI = 1.32–2.27) and 67 percent in men (PR = 1.67, 95% CI = 1.21–2.30). The association between depression and ideation was stronger among unmarried women officers (PR = 4.43; 95% CI = 2.19–8.91) than married women officers (PR = 1.39, 95% CI = 1.09–1.79). While depression has previously been associated with suicide, such results are unusual in a healthy working population such as the police. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - suicide ideation
KW - police officers
KW - potential influences
KW - demographic characteristics
KW - suicide risk
KW - 2009
KW - Demographic Characteristics
KW - Police Personnel
KW - Risk Factors
KW - Suicidal Ideation
KW - Suicide
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health. Recipients: No recipient indicated
DO - 10.1007/s12103-008-9049-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-05792-005&site=ehost-live&scope=site
UR - violanti@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-10667-008
AN - 2009-10667-008
AU - Stiles, Anne Scott
AU - Wilson, Diane
AU - Thompson, Kenneth
T1 - Description and application of personal boundary theory in traumatized adults through the use of Russian stacking dolls.
JF - Traumatology
JO - Traumatology
JA - Traumatology (Tallahass Fla)
Y1 - 2009/06//
VL - 15
IS - 2
SP - 60
EP - 77
CY - US
PB - Sage Publications
SN - 1534-7656
SN - 1085-9373
AD - Stiles, Anne Scott, Texas Woman’s University College of Nursing, Denton Campus, P.O. Box 425498, Denton, TX, US, 76204-5498
N1 - Accession Number: 2009-10667-008. Other Journal Title: Traumatology: An International Journal. Partial author list: First Author & Affiliation: Stiles, Anne Scott; Texas Woman’s University College of Nursing, Denton, TX, US. Other Publishers: Academy of Traumatology; Educational Publishing Foundation; Green Cross Project. Release Date: 20090914. Correction Date: 20140616. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Intimacy; Personal Space; Psychological Theories; Trauma. Minor Descriptor: Insight. Classification: Neuroses & Anxiety Disorders (3215). Population: Human (10). References Available: Y. Page Count: 18. Issue Publication Date: Jun, 2009. Copyright Statement: The Author(s). 2009.
AB - Personal Space Boundary theory, developed by the first author in 1986, explains the complexities of privacy and intimacy within human beings. The way that people choose to relate to others is dependent on the permeability and flexibility of their personal space boundaries. The experience of trauma can damage the functioning of one's boundaries. The introduction of a new analog model of the theory, Russian Stacking Dolls, will demonstrate how the theory provides insight and facilitates healing in adults who have suffered some sort of trauma. The purpose of this article is to review the theory's evolution and provide clinical examples of how this theory is currently being used in practice with Russian Stacking Dolls. Limitations and cautions for use with certain clients are explicated. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - intimacy
KW - insight
KW - trauma
KW - personal space boundary theory
KW - 2009
KW - Intimacy
KW - Personal Space
KW - Psychological Theories
KW - Trauma
KW - Insight
KW - 2009
DO - 10.1177/1534765609333783
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-10667-008&site=ehost-live&scope=site
UR - astiles@mail.twu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07542-004
AN - 2009-07542-004
AU - Drukker, Marjan
AU - Wojciechowski, Franz
AU - Feron, Frans J. M.
AU - Mengelers, Ron
AU - Van Os, Jim
T1 - A community study of psychosocial functioning and weight in young children and adolescents.
JF - International Journal of Pediatric Obesity
JO - International Journal of Pediatric Obesity
JA - Int J Pediatr Obes
Y1 - 2009/06//
VL - 4
IS - 2
SP - 91
EP - 97
CY - US
PB - Informa Healthcare
SN - 1747-7166
SN - 1747-7174
AD - Drukker, Marjan, Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO Box 616, 6200 MD, Maastricht, Netherlands
N1 - Accession Number: 2009-07542-004. PMID: 18792853 Other Journal Title: Pediatric Obesity. Partial author list: First Author & Affiliation: Drukker, Marjan; Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, Netherlands. Other Publishers: Taylor & Francis; Wiley-Blackwell Publishing Ltd. Release Date: 20100308. Correction Date: 20120220. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Psychopathology; Child Psychopathology; Overweight; Psychosocial Factors; Underweight. Minor Descriptor: Age Differences; Obesity. Classification: Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jun, 2009. Publication History: Accepted Date: Jul 20, 2008; First Submitted Date: Dec 6, 2007. Copyright Statement: Informa UK Ltd. 2009.
AB - Background: Children with either underweight or overweight may be at risk for mental health problems and require mental health service use. The present study investigated the relationship between weight status and psychosocial dysfunctioning in children of two different age groups (5-6 and 13-14 years). Methods: Using height and weight measurements collected during routine medical examinations of all children in a circumscribed geographical region, measures of underweight and overweight were calculated in young children (aged 5-6 years; n = 797) and in adolescents (13-14 years; n = 614). In addition, parent-reported questionnaires (young children) and adolescent-reported questionnaires (adolescents), including the Strengths and Difficulties Questionnaire (SDQ), provided information on psychopathology subscales including emotional symptoms, conduct problems, hyperactivity-inattention, peer problems and prosocial behaviour. Results: Few associations were apparent after controlling for confounding variables. Young children who were underweight (but not severely underweight) less frequently displayed conduct problems, while adolescents who were overweight or obese reported more peer problems and less prosocial behaviour than did children of normal weight. Children who were underweight and children who were overweight did not score higher on any of the other psychopathology scales than did children of normal weight in either age group. Conclusion: Our findings suggest that the domains of weight problems and psychopathology do not display strong associations. However, there are indications that some areas of psychopathology may be differentially associated with weight problems. Further longitudinal research is warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychosocial functioning
KW - young children
KW - adolescents
KW - underweight
KW - overweight
KW - weight status
KW - 2009
KW - Adolescent Psychopathology
KW - Child Psychopathology
KW - Overweight
KW - Psychosocial Factors
KW - Underweight
KW - Age Differences
KW - Obesity
KW - 2009
DO - 10.1080/17477160802395442
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07542-004&site=ehost-live&scope=site
UR - Marjan.Drukker@sp.unimaas.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08572-001
AN - 2009-08572-001
AU - Bone, Paula Fitzgerald
AU - France, Karen Russo
AU - Aikin, Kathryn J.
T1 - On break-up clichés guiding health literacy’s future.
JF - Journal of Consumer Affairs
JO - Journal of Consumer Affairs
JA - J Consum Aff
Y1 - 2009///Sum 2009
VL - 43
IS - 2
SP - 185
EP - 198
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0022-0078
SN - 1745-6606
N1 - Accession Number: 2009-08572-001. Partial author list: First Author & Affiliation: Bone, Paula Fitzgerald; West Virginia University, Morgantown, WV, US. Other Publishers: Blackwell Publishing. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Education. Minor Descriptor: Life Experiences; Literacy; Health Personnel. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10). References Available: Y. Page Count: 14. Issue Publication Date: Sum 2009. Copyright Statement: The American Council on Consumer Interests. 2009.
AB - The pragmatic directive is to move beyond documenting consumer frailties, and turn to theory-based research designed to create health care systems which maximize consumer health literacy. This agenda must incorporate the communicators (the health care professionals, the insurance providers, the lawyers’ requirements, the government regulators, the Courts, the bench scientists), the receivers of information, and the context in which the information is generated. To this end, we present observations that use common life experiences as the framework for progress. Perhaps, we erroneously assume that most readers have experience with the romantic break-up, but we will forgo some of our own advice, reasoning that most of us have at least second-hand experience with these clichés. Undoubtedly, clichés become clichés because of the underlying element of truth. These common tales of break-up in life and popular culture provide a basis to explain the value of a new approach. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health education
KW - health care services
KW - consumer education
KW - life experiences
KW - 2009
KW - Health Care Services
KW - Health Education
KW - Life Experiences
KW - Literacy
KW - Health Personnel
KW - 2009
DO - 10.1111/j.1745-6606.2009.01136.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08572-001&site=ehost-live&scope=site
UR - kathryn.aikin@fda.hhs.gov
UR - karen.france@mail.wvu.edu
UR - paula.bone@mail.wvu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-10196-006
AN - 2009-10196-006
AU - Sakai, Yoshie
AU - Akiyama, Tsuyoshi
AU - Kawamura, Yoshiya
AU - Matsumoto, Satoko
AU - Tominaga, Maki
AU - Kurabayashi, Lumie
AU - Miyake, Yuko
AU - Akiskal, Kareen
AU - Akiskal, Hagop
T1 - Temperament and melancholic type: Path analysis of a prospective study of depressive mood change in a nonclinical population.
JF - Psychopathology
JO - Psychopathology
JA - Psychopathology
Y1 - 2009/06//
VL - 42
IS - 4
SP - 249
EP - 256
CY - Switzerland
PB - Karger
SN - 0254-4962
SN - 1423-033X
AD - Sakai, Yoshie, Department of Psychiatry, Juntendo University School of Medicine, 560, Fukuroyama, Saitama, Koshigaya City, Japan, 343-0032
N1 - Accession Number: 2009-10196-006. PMID: 19521141 Other Journal Title: Psychiatria Clinica. Partial author list: First Author & Affiliation: Sakai, Yoshie; Department of Psychiatry, Juntendo University School of Medicine, Koshigaya City, Japan. Release Date: 20090914. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Affective Disorders; Major Depression; Path Analysis; Personality Traits. Minor Descriptor: Emotional States. Classification: Personality Traits & Processes (3120). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Temperament and Personality Traits Scales; Coping Inventory of Stressful Situations; Munich Personality Test; Center for Epidemiologic Studies Depression Scale; Dysfunctional Attitude Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2009. Publication History: First Posted Date: Jun 12, 2009; Accepted Date: Sep 10, 2008; First Submitted Date: Feb 16, 2008. Copyright Statement: S. Karger AG, Basel. 2009.
AB - Background: Recent studies suggest that mood-disorder-related personality traits predict depressive mood changes (DMC) in nonclinical populations. Sampling and Methods: In this study we examined the predictability of DMC in a nonclinical sample consisting of 351 Japanese company employees, with temperament and melancholic type personality as measured by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego and the Munich Personality Test. We also analyzed the mediating roles of dysfunctional attitudes and coping styles. Subjects were assessed for depressive mood, temperament and personality traits in May 2002 (time 1) and May 2004 (time 2), and dysfunctional attitudes and coping styles at time 2. Results and Conclusion: Results of hierarchical multiple regressions showed that depressive, cyclothymic and hyperthymic temperaments and melancholic type at time 1 significantly predicted DMC from time 1 to time 2, after controlling for demographic variables and the level of depressive mood at time 1. Path analysis results showed that depressive, cyclothymic and hyperthymic temperaments and melancholic type significantly predicted DMC, a certain part of the influence of depressive, cyclothymic and hyperthymic temperaments and melancholic type was significantly mediated via coping styles and that the influence of melancholic type was also mediated via dysfunctional attitudes. These findings provide clues for the targeting of interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - temperament
KW - melancholia
KW - path analysis
KW - depressive mood change
KW - mood disorder
KW - personality traits
KW - 2009
KW - Affective Disorders
KW - Major Depression
KW - Path Analysis
KW - Personality Traits
KW - Emotional States
KW - 2009
DO - 10.1159/000224148
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-10196-006&site=ehost-live&scope=site
UR - y-sakai@sb3.so-net.ne.jp
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07195-006
AN - 2009-07195-006
AU - Bedell-Avers, Katrina
AU - Hunter, Samuel T.
AU - Angie, Amanda D.
AU - Eubanks, Dawn L.
AU - Mumford, Michael D.
T1 - Charismatic, ideological, and pragmatic leaders: An examination of leader-leader interactions.
JF - The Leadership Quarterly
JO - The Leadership Quarterly
JA - Leadersh Q
Y1 - 2009/06//
VL - 20
IS - 3
SP - 299
EP - 315
CY - Netherlands
PB - Elsevier Science
SN - 1048-9843
AD - Bedell-Avers, Katrina, University of Oklahoma, 13575 SW 29th St., Yukon, OK, US, 73099
N1 - Accession Number: 2009-07195-006. Partial author list: First Author & Affiliation: Bedell-Avers, Katrina; University of Oklahoma, Yukon, OK, US. Release Date: 20090907. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Charisma; Leadership Style; Pragmatism. Minor Descriptor: Social Interaction. Classification: Management & Management Training (3640). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Jun, 2009.
AB - Although a number of researchers have examined and demonstrated the unique relationships different types of leaders develop with their followers (Dansereau, F., Graen, G.B., & Haga, W.J. (1975). A vertical dyad linkage approach to leadership within formal organizations: A longitudinal investigation of the role making process. Organizational Behavior and Human Performance, 13, 46–78.; Dienesh & Liden, 1986; Mumford, 2006), relatively little is known regarding how outstanding leaders interact or work together (Hunter, Bedell-Avers, Mumford, 2009-this issue). Given the particular importance of such questions, especially when considering leaders who have the potential to influence national and worldwide developments, the intent of the present study was to examine the leader–leader exchange relationships of charismatic, ideological, and pragmatic leaders. Due to the difficulty associated with examining high-level leader–leader exchanges, a hybrid qualitative–quantitative approach was taken to assess the interactions of Frederick Douglas, W.E.B. Dubois, and Booker T. Washington—three high-level leaders who responded to the same crisis, in the same time period, in the same region of the world. The results provide preliminary evidence regarding the interactions of charismatic, ideological, and pragmatic leaders; in fact, they indicate that leaders interact in a manner consistent with their mental model. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - charismatic leaders
KW - ideological leaders
KW - pragmatic leaders
KW - leader leader interactions
KW - 2009
KW - Charisma
KW - Leadership Style
KW - Pragmatism
KW - Social Interaction
KW - 2009
DO - 10.1016/j.leaqua.2009.03.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07195-006&site=ehost-live&scope=site
UR - mmumford@ou.edu
UR - D.Eubanks@bath.ac.uk
UR - Amanda.Angie@HHS.gov
UR - samhunter@psu.edu
UR - katrina.avers@faa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08204-011
AN - 2009-08204-011
AU - Meng, Hongdao
AU - Wamsley, Brenda
AU - Liebel, Diane
AU - Dixon, Denise
AU - Eggert, Gerald
AU - Van Nostrand, Joan
T1 - Urban-rural differences in the effect of a Medicare health promotion and disease self- management program on physical function and health care expenditures.
JF - The Gerontologist
JO - The Gerontologist
JA - Gerontologist
Y1 - 2009/06//
VL - 49
IS - 3
SP - 407
EP - 417
CY - United Kingdom
PB - Oxford University Press
SN - 0016-9013
SN - 1758-5341
AD - Meng, Hongdao, Department of Preventive Medicine, State University of New York at Stony Brook, HSC, Level 3, Rm071, Stony Brook, NY, US, 11794-8338
N1 - Accession Number: 2009-08204-011. PMID: 19401357 Partial author list: First Author & Affiliation: Meng, Hongdao; Department of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, NY, US. Other Publishers: Gerontological Society of America. Release Date: 20100322. Correction Date: 20131202. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Activities of Daily Living; Health Care Costs; Health Promotion; Intervention; Medicare. Minor Descriptor: Health; Rural Environments; Self-Management; Urban Environments. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jun, 2009. Publication History: Accepted Date: May 2, 2008; First Submitted Date: Feb 4, 2008. Copyright Statement: The Author. 2009.
AB - Purpose: To evaluate the impact of a multi component health promotion and disease self-management intervention on physical function and health care expenditures among Medicare beneficiaries. To determine if these outcomes vary by urban or rural residence. Design and Methods: We analyzed data from a 22-month randomized controlled trial of a health promotion/disease self-management program that included 766 elderly Medicare beneficiaries from western New York, West Virginia, and Ohio. Physical function was measured by changes in self-reported dependencies in activities of daily living over the study period. Total health care expenditures were measured by aggregating expenditures from major sources (acute, post acute, and long-term care). We used ordinary least squares models to examine the effects of the intervention on both physical function and cost outcomes during the 22-month period. Results: The results indicated that the intervention reduced physical functional decline by 54% (p = .03) in the study sample. Stratified analyses showed that the intervention effect was much stronger in the rural sample. Mean total health care expenditures were 11% ($3,100, p = .30) lower in the intervention group. The effects of the intervention on average health care expenditures were similar among urban and rural participants. Implications: The intervention offered a promising strategy for reducing decline in physical function and potentially lowering total health care expenditures for high-risk Medicare beneficiaries, especially for those in rural areas. Future studies need to investigate whether the findings can be replicated in other types of rural areas through a refined intervention and better targeting of the study population. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health promotion
KW - disease management
KW - prevention
KW - expenditures
KW - rural
KW - physical function
KW - Medicare
KW - urban
KW - residence
KW - activities of daily living
KW - 2009
KW - Activities of Daily Living
KW - Health Care Costs
KW - Health Promotion
KW - Intervention
KW - Medicare
KW - Health
KW - Rural Environments
KW - Self-Management
KW - Urban Environments
KW - 2009
DO - 10.1093/geront/gnp057
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08204-011&site=ehost-live&scope=site
UR - hongdao.meng@stonybrook.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06760-009
AN - 2009-06760-009
AU - Vandivort, Rita
AU - Teich, Judith L.
AU - Cowell, Alexander J.
AU - Chen, Hong
T1 - Utilization of substance abuse treatment services under Medicare, 2001-2002.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2009/06//
VL - 36
IS - 4
SP - 414
EP - 419
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Vandivort, Rita, Substance Abuse Mental Health Services Administration, Center for Substance Abuse Treatment, Room 5-1107, 1 Choke Cherry Ln, Rockville, MD, US, 20857
N1 - Accession Number: 2009-06760-009. PMID: 18835680 Partial author list: First Author & Affiliation: Vandivort, Rita; Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, US. Release Date: 20090810. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Drug Rehabilitation; Geriatrics; Health Care Utilization; Medicare. Minor Descriptor: Detoxification. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2009.
AB - In 2006, the Medicare program covered 37 million elderly persons and 7 million persons younger than 65 years, but little is known about substance abuse (SA) service utilization. Using the 5% Sample of Medicare claims data, the study examines individuals who used SA detoxification ('detox') and/or rehabilitation ('rehab') services under Medicare in 2001 and 2002. SA claimants less than 65 years of age (disabled) were compared to claimants more than 65 years of age (elderly). The disabled were more likely to have a co-occurring mental disorder than elderly claimants (50% vs. 14%) and more likely to have serious mental illness (21% vs. 2.3%). Disabled claimants were more than three times as likely to receive any detox service as elderly claimants (17% vs. 6%). The rate of claimants receiving rehab services within 30 days of detox is about one third for disabled claimants and one quarter for elderly claimants. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health service utilization
KW - substance abuse treatment
KW - medicare
KW - elderly persons
KW - drug rehabilitation
KW - detoxification
KW - 2009
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Geriatrics
KW - Health Care Utilization
KW - Medicare
KW - Detoxification
KW - 2009
DO - 10.1016/j.jsat.2008.08.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06760-009&site=ehost-live&scope=site
UR - rita.vandivort@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-11814-002
AN - 2010-11814-002
AU - van Veen, M. G.
AU - Kramer, M. A.
AU - Op de Coul, E. L. M.
AU - van Leeuwen, A. P.
AU - de Zwart, O.
AU - van de Laar, M. J. W.
AU - Coutinho, R. A.
AU - Prins, M.
T1 - Disassortative sexual mixing among migrant populations in the Netherlands: A potential for HIV/STI transmission?
JF - AIDS Care
JO - AIDS Care
JA - AIDS Care
Y1 - 2009/06//
VL - 21
IS - 6
SP - 683
EP - 691
CY - United Kingdom
PB - Taylor & Francis
SN - 0954-0121
SN - 1360-0451
AD - van Veen, M. G.
N1 - Accession Number: 2010-11814-002. PMID: 19806484 Partial author list: First Author & Affiliation: van Veen, M. G.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands. Release Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Condoms; Demographic Characteristics; HIV; Psychosexual Behavior; Sexually Transmitted Diseases. Minor Descriptor: Human Migration. Classification: Sexual Behavior & Sexual Orientation (2980). Population: Human (10); Male (30); Female (40). Location: Cape Verde; Ghana; Netherlands; Surinam. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jun, 2009. Publication History: Revised Date: Sep 29, 2008; First Submitted Date: May 6, 2008. Copyright Statement: Taylor & Francis. 2009.
AB - To gain insight into the transmission of HIV and sexually transmitted infection (STI) among large migrant groups in the Netherlands, we studied the associations between their demographic and sexual characteristics, in particular condom use, and their sexual mixing patterns with other ethnic groups. In 2002-2005, cross-sectional surveys were conducted among migrants from Surinam (Afro- and Hindo-), the Netherlands Antilles, Cape Verde, and Ghana at social venues in three large cities. A questionnaire was administrated and a saliva sample was collected for HIV antibody testing. Of 2105 migrants recruited, 1680 reported sexual contacts, of whom 41% mixed sexually with other ethnicities, including the indigenous Dutch population. Such disassortative mixing was associated with being second-generation migrant, having several sexual partners, and having a steady and concurrent casual partner. Less disassortative mixing occurred in participants reporting visiting the country of origin. The association between condom use and sexual mixing differed by gender, with men using condoms inconsistently being most likely to be mixing with the Dutch indigenous population. HIV infection and recent STI treatment were not associated with disassortative mixing. This study shows substantial sexual mixing among migrant groups. Since disassortative mixing is more prevalent in second-generation migrants, it might increase in the upcoming years. The mixing patterns in relation to concurrency and the reported condom use in this study suggest a possibly increased level of HIV/STI transmission not only within migrant groups but also between migrant groups, especially via men who mix with the indigenous population and via migrant women who mix with non-Dutch casual partners. Although the observed HIV prevalence in migrants (0.6%) is probably too low to lead to much HIV transmission between ethnicity groups, targeted prevention measures are needed to prevent transmission of other STI. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - disassortative sexual mixing patterns
KW - migrant populations
KW - Netherlands
KW - HIV
KW - sexually transmitted infection
KW - condom usage
KW - demographic characteristics
KW - sexual characteristics
KW - ethnic groups
KW - 2009
KW - Condoms
KW - Demographic Characteristics
KW - HIV
KW - Psychosexual Behavior
KW - Sexually Transmitted Diseases
KW - Human Migration
KW - 2009
U1 - Sponsor: AIDS Foundation, Netherlands. Grant: 7015. Recipients: No recipient indicated
DO - 10.1080/09540120802511984
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-11814-002&site=ehost-live&scope=site
UR - maaike.van.veen@rivm.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17087-004
AN - 2009-17087-004
AU - Joseph, P. Nedra
AU - Violanti, John M.
AU - Donahue, Richard
AU - Andrew, Michael E.
AU - Trevisan, Maurizio
AU - Burchfiel, Cecil M.
AU - Dorn, Joan
T1 - Police work and subclinical atherosclerosis.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2009/06//
VL - 51
IS - 6
SP - 700
EP - 707
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - Joseph, P. Nedra, NIOSH/CDC, 1095 Willowdale Road M/S 4050, Morgantown, WV, US, 26505
N1 - Accession Number: 2009-17087-004. PMID: 19530342 Partial author list: First Author & Affiliation: Joseph, P. Nedra; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, US. Release Date: 20100322. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Atherosclerosis; Cardiovascular Disorders; Carotid Arteries; Employment Status; Police Personnel. Minor Descriptor: At Risk Populations. Classification: Physical & Somatoform & Psychogenic Disorders (3290); Police & Legal Personnel (4290). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2009. Copyright Statement: American College of Occupational and Environmental Medicine. 2009.
AB - Objective: Employment as an urban police officer was hypothesized to be associated with increased structural subclinical cardiovascular disease (CVD), measured by carotid artery intima-media thickness (IMT). Methods: The sample of men and women consisted of police officers (n = 312) and the general population (n = 318), free of clinical CVD. Results: Officers had elevated levels of age-adjusted CVD risk factors (blood pressure, total cholesterol, smoking prevalence) compared with the population sample. In age-, gender-, and traditional risk factor-adjusted models, police officers exhibited increased mean common carotid IMT (police = 0.67 mm, population = 0.64 mm; P = 0.03) and mean maximum carotid IMT (police = 0.99 mm, population = 0.95 mm; P = 0.13). Conclusions: Police officers have increased levels of atherosclerosis compared with a general population sample, which was not fully explained by elevated CVD risk factors; thereby potentially implicating other mechanisms whereby law enforcement work may increase CVD risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - police work
KW - subclinical atherosclerosis
KW - cardiovascular disease
KW - carotid artery intima-media thickness
KW - 2009
KW - Atherosclerosis
KW - Cardiovascular Disorders
KW - Carotid Arteries
KW - Employment Status
KW - Police Personnel
KW - At Risk Populations
KW - 2009
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, US. Other Details: Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Alcohol Abuse and Alcoholism, US. Other Details: The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS). Recipients: No recipient indicated
U1 - Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases, US. Other Details: The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS). Recipients: No recipient indicated
DO - 10.1097/JOM.0b013e3181a02252
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17087-004&site=ehost-live&scope=site
UR - PNJoseph@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07670-013
AN - 2009-07670-013
AU - Selden, Thomas M.
T1 - The within-year concentration of medical care: Implications for family out-of-pocket expenditure burden.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2009/06//
VL - 44
IS - 3
SP - 1029
EP - 1051
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - Selden, Thomas M., Division of Modeling and Simulation, Department of Health and Human Services, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2009-07670-013. PMID: 19674431 Partial author list: First Author & Affiliation: Selden, Thomas M.; Division of Modeling and Simulation, Department of Health and Human Services, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Family; Health Care Costs; Health Care Services; Health Care Utilization; Income Level. Minor Descriptor: Health Insurance. Classification: Health & Mental Health Services (3370). Population: Human (10); Inpatient (50); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 23. Issue Publication Date: Jun, 2009. Copyright Statement: Health Research and Educational Trust
AB - Objective: To examine the within-year concentration of family health care and the resulting exposure of families to short periods of high expenditure burdens. Data Source: Household data from the pooled 2003 and 2004 Medical Expenditure Panel Survey (MEPS) yielding nationally representative estimates for the nonelderly civilian noninstitutionalized population. Study Design: The paper examines the within-year concentration of family medical care use and the frequency with which family out-of-pocket expenditures exceeded 20 percent of family income, computed at the annual, quarterly, and monthly levels. Principal Findings: On average among families with medical care, 49 percent of all (charge-weighted) care occurred in a single month, and 63 percent occurred in a single quarter). Nationally, 27 percent of the study population experienced at least 1 month in which out-of-pocket expenditures exceeded 20 percent of income. Monthly 20 percent burden rates were highest among the poor, at 43 percent, and were close to or above 30 percent for all but the highest income group (families above four times the federal poverty line). Conclusions: Within-year spikes in health care utilization can create financial pressures missed by conventional annual burden analyses. Within-year health-related financial pressures may be especially acute among lower-income families due to low asset holdings. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical care
KW - expenditure burden
KW - family health care
KW - family income
KW - 2009
KW - Family
KW - Health Care Costs
KW - Health Care Services
KW - Health Care Utilization
KW - Income Level
KW - Health Insurance
KW - 2009
DO - 10.1111/j.1475-6773.2009.00963.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07670-013&site=ehost-live&scope=site
UR - tselden@ahrq.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07401-018
AN - 2009-07401-018
AU - Lescano, Celia M.
AU - Houck, Christopher D.
AU - Brown, Larry K.
AU - Doherty, Glenn
AU - DiClemente, Ralph J.
AU - Fernandez, M. Isabel
AU - Pugatch, David
AU - Schlenger, William E.
AU - Silver, Barbara J.
T1 - Correlates of heterosexual anal intercourse among at-risk adolescents and young adults.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/06//
VL - 99
IS - 6
SP - 1131
EP - 1136
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Lescano, Celia M., Bradley/Hasbro Children’s Research Center, One Hoppin St, Suite 204, Providence, RI, US, 02903
N1 - Accession Number: 2009-07401-018. PMID: 19008522 Partial author list: First Author & Affiliation: Lescano, Celia M.; Bradley Hasbro Children’s Research Center, Providence, RI, US. Institutional Authors: The Project SHIELD Srudy Group. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Adolescent Attitudes; Adult Offspring; At Risk Populations; Heterosexuality; Sexual Intercourse (Human). Minor Descriptor: Drug Usage; Mental Health. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320). Tests & Measures: Drug Influence Scale; Hedonism Scale; Perceived Invulnerability Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Jun, 2009. Publication History: Accepted Date: Mar 28, 2008.
AB - Objectives: We sought to learn what factors are associated with anal intercourse among adolescents and young adults. We examined demographic, behavioral, relationship context, attitudinal, substance use, and mental health correlates of recent heterosexual anal intercourse among adolescents and young adults who reported engaging in recent unprotected sex. Methods: Among 1348 at-risk adolescents and young adults aged 15 to 21 years in 3 US cities, we assessed sexual risk behavior with each sexual partner in the past 90 days. Data were collected from 2000 to 2001. Results: Recent heterosexual anal intercourse was reported by 16% of respondents. Females who engaged in anal intercourse were more likely to be living with a sexual partner, to have had 2 or more partners, and to have experienced coerced intercourse. For males, only a sexual orientation other than heterosexual was a significant predictor of engaging in heterosexual anal intercourse. Conclusions: Our findings document the prevalence of heterosexual anal intercourse among adolescents and young adults who had recent unprotected sex. Among females, the variables associated with anal intercourse relate to the context and power balance of sexual relationships. Different influences for males and females suggest different foci for interventions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - heterosexuality
KW - anal intercourse
KW - at risk adolescents
KW - young adults
KW - substance use
KW - mental health
KW - 2009
KW - Adolescent Attitudes
KW - Adult Offspring
KW - At Risk Populations
KW - Heterosexuality
KW - Sexual Intercourse (Human)
KW - Drug Usage
KW - Mental Health
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: U10 SMS2073. Other Details: The cooperating sites (i.e., Rhode Island Hospital, Miriam Hospital, Emory University, and University of Miami). Recipients: No recipient indicated
U1 - Sponsor: Lifespan/Tufts/Brown Center for AIDS Research. Recipients: No recipient indicated
DO - 10.2105/AJPH.2007.123752
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07401-018&site=ehost-live&scope=site
UR - clescano@lifespan.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-07332-003
AN - 2009-07332-003
AU - Schaffer, Susan D.
AU - Yoon, Saunjoo
AU - Zadezensky, Immo
T1 - A review of smoking cessation: Potentially risky effects on prescribed medications.
JF - Journal of Clinical Nursing
JO - Journal of Clinical Nursing
JA - J Clin Nurs
Y1 - 2009/06//
VL - 18
IS - 11
SP - 1533
EP - 1540
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0962-1067
SN - 1365-2702
AD - Yoon, Saunjoo, University of Florida College of Nursing, HPNP Complex, P. O. Box 100187, 101 S Newell Drive, Gainesville, FL, US, 32610-0187
N1 - Accession Number: 2009-07332-003. PMID: 19490292 Partial author list: First Author & Affiliation: Schaffer, Susan D.; University of Florida, College of Nursing, Gainesville, FL, US. Other Publishers: Blackwell Publishing. Release Date: 20090817. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Prescription Drugs; Risk Factors; Smoking Cessation. Minor Descriptor: Drug Dosages. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 8. Issue Publication Date: Jun, 2009.
AB - Aims and objectives: To identify prescription drugs that require dosage adjustment or monitoring in patients who quit smoking and to provide recommendations for dosage adjustment based on available evidence. Background: Health care providers are urged to facilitate smoking cessation for patients who smoke, but the effects of smoking cessation on the metabolism of some drugs is not routinely considered. Design: A comprehensive literature review. Methods: The review was conducted in 2008 using a computerized drug interaction program and multiple PubMed and CINAHL searches to identify prescription drugs with clinically significant pharmacokinetic or pharmacodynamic changes caused by smoking cessation. Results: Although much of the evidence is case report, dosage adjustments are clearly indicated for warfarin, olanzapine, clozapine and theophylline since they are metabolized by cytochrome P450 CYP1A2 and also have narrow therapeutic ratios. Careful monitoring is recommended for other CYP1A2 metabolized drugs, including those for hypertension and Alzheimer's disease. For many affected drugs, smoking cessation reverses smoking-induced CYP1A2 hepatic enzyme levels to normal, increasing plasma concentrations in patients whose dose was established while smoking. Because the effect on hepatic microsomal enzymes is not related to the nicotine component of tobacco, nicotine replacement will not alter the effect. Conclusions: The effects of smoking cessation on drugs metabolized by CYP1A2 have been under-appreciated by health care providers. Smoking cessation may increase plasma levels of some drugs to potentially toxic levels. Further research is warranted to clarify this effect. Relevance to clinical practice: When patients stop smoking, providers should carefully review prescribed drug regimens and adjust or monitor drugs whose metabolism is affected by smoking cessation. This is particularly important for patients who abruptly stop smoking due to hospitalization and for older patients who are likely to be taking multiple medications. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - smoking cessation
KW - prescribed medications
KW - risk factors
KW - dosage adjustment
KW - 2009
KW - Prescription Drugs
KW - Risk Factors
KW - Smoking Cessation
KW - Drug Dosages
KW - 2009
DO - 10.1111/j.1365-2702.2008.02724.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-07332-003&site=ehost-live&scope=site
UR - yoon@ufl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105376746
T1 - Psychological distress and mental health treatment among persons with and without active duty military experience, Behavioral Risk Factor Surveillance System, United States, 2007.
AU - Safran MA
AU - Strine TW
AU - Dhingra SS
AU - Berry JT
AU - Manderscheid R
AU - Mokdad AH
Y1 - 2009/06/02/
N1 - Accession Number: 105376746. Language: English. Entry Date: 20091127. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Continental Europe; Europe; Public Health. Special Interest: Public Health. NLM UID: 101304551.
KW - Mental Health Services -- Utilization
KW - Military Personnel -- Psychosocial Factors
KW - Stress Disorders, Post-Traumatic -- Epidemiology
KW - Stress, Psychological -- Epidemiology
KW - Stress, Psychological -- Therapy
KW - Veterans -- Psychosocial Factors
KW - Adolescence
KW - Adult
KW - Aged
KW - Female
KW - Male
KW - Mental Disorders -- Epidemiology
KW - Mental Disorders -- Therapy
KW - Middle Age
KW - Military Personnel -- Statistics and Numerical Data
KW - Risk Assessment
KW - Stress Disorders, Post-Traumatic -- Therapy
KW - United States
KW - Veterans -- Statistics and Numerical Data
KW - War
SP - 61
EP - 67
JO - International Journal of Public Health
JF - International Journal of Public Health
JA - INT J PUBLIC HEALTH
VL - 54
CY - ,
PB - Springer Science & Business Media B.V.
SN - 1661-8556
AD - U.S. Public Health Service, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30333, USA. MSafran@cdc.gov
U2 - PMID: 19407930.
DO - 10.1007/s00038-009-0008-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105376746&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - van Houdt, R.
AU - Koedijk, F.D.H.
AU - Bruisten, S.M.
AU - Coul, E.L.M. Op de
AU - Heijnen, M.L.A.
AU - Waldhober, Q.
AU - Veldhuijzen, I.K.
AU - Richardus, J.H.
AU - Schutten, M.
AU - van Doornum, G.J.J.
AU - de Man, R.A.
AU - Hahné, S.J.
AU - Coutinho, R.A.
AU - Boot, H.J.
T1 - Hepatitis B vaccination targeted at behavioural risk groups in the Netherlands: Does it work?
JO - Vaccine
JF - Vaccine
Y1 - 2009/06/02/
VL - 27
IS - 27
M3 - Article
SP - 3530
EP - 3535
SN - 0264410X
AB - Abstract: In November 2002, the Netherlands adopted a vaccination program targeted at behavioural risk groups. Between January 2003 and December 2007, 1386 patients acutely infected with HBV were reported. Reported cases declined from 326 in 2003 to 220 in 2007. Sexual intercourse was the most frequently reported mode of transmission (65%), especially among men having sex with men. Genotypes A and D remained predominant. In total, 40,600 participants were fully vaccinated, the overall compliance was 62%, and the estimated overall program coverage was 12% of the at-risk population. With more effort, more susceptibles may be reached, but the program will not be sufficient to substantially reduce HBV in the Netherlands. Therefore, universal vaccination should be considered. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B -- Vaccination
KW - AT-risk behavior
KW - PATIENT compliance
KW - AT-risk people
KW - SEXUAL intercourse
KW - SEXUALLY transmitted diseases
KW - MOLECULAR epidemiology
KW - HEALTH programs
KW - NETHERLANDS
KW - Hepatitis B
KW - Molecular epidemiology
KW - Risk groups
KW - Targeted vaccination
N1 - Accession Number: 40116784; van Houdt, R. 1 Koedijk, F.D.H. 2 Bruisten, S.M. 1,3 Coul, E.L.M. Op de 2 Heijnen, M.L.A. 4,5 Waldhober, Q. 5 Veldhuijzen, I.K. 6 Richardus, J.H. 6,7 Schutten, M. 7 van Doornum, G.J.J. 7 de Man, R.A. 7 Hahné, S.J. 2 Coutinho, R.A. 2,3 Boot, H.J. 2; Email Address: hein.boot@rivm.nl; Affiliation: 1: Public Health Service, Department of Infectious Diseases, Amsterdam, The Netherlands 2: Centre for Infectious Disease Control, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands 3: Academic Medical Centre, University of Amsterdam, CINIMA, Amsterdam, The Netherlands 4: Centre for Population Screening, National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands 5: The Netherlands Association of Public Health Services, Utrecht, The Netherlands 6: Municipal Public Health Service Rotterdam Rijnmond, Division of Infectious Disease Control, Rotterdam, The Netherlands 7: Erasmus MC, University Medical Centre Rotterdam, Departments of Gastroenterology and Virology, Rotterdam, The Netherlands; Source Info: Jun2009, Vol. 27 Issue 27, p3530; Subject Term: HEPATITIS B -- Vaccination; Subject Term: AT-risk behavior; Subject Term: PATIENT compliance; Subject Term: AT-risk people; Subject Term: SEXUAL intercourse; Subject Term: SEXUALLY transmitted diseases; Subject Term: MOLECULAR epidemiology; Subject Term: HEALTH programs; Subject Term: NETHERLANDS; Author-Supplied Keyword: Hepatitis B; Author-Supplied Keyword: Molecular epidemiology; Author-Supplied Keyword: Risk groups; Author-Supplied Keyword: Targeted vaccination; NAICS/Industry Codes: 912910 Other provincial and territorial public administration; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.03.072
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40116784&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hrivňák, Ján
AU - Tölgyessy, Peter
AU - Kráľovičová, Eva
T1 - On-column injection system for use of large diameter inside needle capillary adsorption trap devices
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2009/06/05/
VL - 1216
IS - 23
M3 - Article
SP - 4815
EP - 4816
SN - 00219673
AB - Abstract: Direct coupling of the needle trap to the capillary column in the split/splitless gas chromatographic (GC) inlet with simple modification facilitates full exploitation of the column efficiency, even when using the large volume trap filled with 35mg of Tenax TA. A schematic diagram of the inlet and of the new modification of the INCAT device and an example of BTEX (benzene, toluene, ethylbenzene and xylenes) analysis is presented. Determination of the repeatability of BTEX analyses resulted in relative standard deviations of 2.4–3.6%. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAS chromatography
KW - ADSORPTION
KW - SAMPLE introduction (Chemistry)
KW - BENZENE, toluene, ethylbenzene, xylene (BTEX)
KW - STANDARD deviations
KW - CHROMATOGRAPHIC analysis
KW - ANALYTICAL chemistry -- Technique
KW - BTEX
KW - INCAT
KW - Needle trap
KW - On-column injection
KW - Sample introduction
KW - Sampling
N1 - Accession Number: 39351748; Hrivňák, Ján 1 Tölgyessy, Peter 2; Email Address: Tolgyessy@vuvh.sk Kráľovičová, Eva 3; Affiliation: 1: Research Institute of Viticulture and Enology, Matúškova 25, 831 01 Bratislava, Slovak Republic 2: Water Research Institute, Nábrežie L. Svobodu 5, 812 49 Bratislava, Slovak Republic 3: Regional Authority of Public Health Service, Bratislava Capital of the Slovak Republic, Ružinovská 8, 820 09 Bratislava, Slovak Republic; Source Info: Jun2009, Vol. 1216 Issue 23, p4815; Subject Term: GAS chromatography; Subject Term: ADSORPTION; Subject Term: SAMPLE introduction (Chemistry); Subject Term: BENZENE, toluene, ethylbenzene, xylene (BTEX); Subject Term: STANDARD deviations; Subject Term: CHROMATOGRAPHIC analysis; Subject Term: ANALYTICAL chemistry -- Technique; Author-Supplied Keyword: BTEX; Author-Supplied Keyword: INCAT; Author-Supplied Keyword: Needle trap; Author-Supplied Keyword: On-column injection; Author-Supplied Keyword: Sample introduction; Author-Supplied Keyword: Sampling; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.chroma.2009.04.030
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=39351748&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ismailoglu, Ugur B.
AU - Scott, Michael R. Van
AU - Fedan, Jeffrey S.
T1 - Effects of cytokines on mechanical and epithelial bioelectric responses to methacholine and hyperosmolarity in guinea-pig airways: An in vitro study
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
Y1 - 2009/06/10/
VL - 612
IS - 1-3
M3 - Article
SP - 115
EP - 121
SN - 00142999
AB - Abstract: We observed previously that lipopolysaccharide (LPS) 18 h after i.p. injection of guinea pigs increased transepithelial potential difference (V t), hyperpolarization responses to methacholine, and hyperosmolarity-induced, epithelium-derived relaxing factor (EpDRF)-mediated relaxation responses, in excised and perfused tracheal segments. To investigate their roles in these changes, the effects of cytokines on in vitro epithelial bioelectric and smooth muscle mechanical responses were investigated using the isolated, perfused trachea preparation. Tracheas were incubated (6 h) with LPS or IL-1β, IL-4, IL-13, IFN-γ, TNF-α, singly or in combination. Incubation with LPS and cytomix (IL-1β+IFN-γ+TNF-α together) had no effect on muscle reactivity to methacholine, but potentiated D-mannitol-induced relaxation. Individually, IL-1β and IFN-γ inhibited methacholine-induced contractions and potentiated D-mannitol-induced relaxation responses. TNF-α increased contractions to methacholine but had no effect on relaxation responses to D-mannitol. Methacholine elicited hyperpolarization in low concentrations and depolarization in high concentrations. The individual cytokines decreased the hyperpolarization response to low methacholine concentrations and increased the depolarization response to high methacholine concentrations but had no effect on V t responses to D-mannitol. Cytomix did not affect V t responses to methacholine, but potentiated both the hyperpolarization and depolarization responses to D-mannitol. In Ussing chambers all agents except IL-1β and IFN-γ increased V t; IL-1β decreased slightly but none of the other agents affected transepithelial resistance (R t). The results indicate that cytokines and LPS alter smooth muscle reactivity to methacholine, potentiate EpDRF-mediated relaxation responses and, thereby, mimic the effects of LPS treatment in vivo, but do not recapitulate LPS'' effects on V t responses. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - GUINEA pigs as laboratory animals
KW - SMOOTH muscle -- Diseases
KW - MUSCLE contraction
KW - CHOLINESTERASES
KW - AIRWAY (Medicine)
KW - PHARMACOLOGY
KW - Cytokine
KW - Epithelium-derived relaxing factor
KW - Guinea-pig trachea
KW - Hyperosmolarity
KW - Lipopolysaccharide
KW - Smooth muscle contractility
KW - Transepithelial potential difference
N1 - Accession Number: 40116502; Ismailoglu, Ugur B. 1,2 Scott, Michael R. Van 3 Fedan, Jeffrey S. 1; Email Address: jsf2@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA 2: Faculty of Pharmacy, Department of Pharmacology, Hacettepe University, 06100 Ankara, Turkey 3: Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC, 27858, USA; Source Info: Jun2009, Vol. 612 Issue 1-3, p115; Subject Term: CYTOKINES; Subject Term: GUINEA pigs as laboratory animals; Subject Term: SMOOTH muscle -- Diseases; Subject Term: MUSCLE contraction; Subject Term: CHOLINESTERASES; Subject Term: AIRWAY (Medicine); Subject Term: PHARMACOLOGY; Author-Supplied Keyword: Cytokine; Author-Supplied Keyword: Epithelium-derived relaxing factor; Author-Supplied Keyword: Guinea-pig trachea; Author-Supplied Keyword: Hyperosmolarity; Author-Supplied Keyword: Lipopolysaccharide; Author-Supplied Keyword: Smooth muscle contractility; Author-Supplied Keyword: Transepithelial potential difference; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ejphar.2009.04.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40116502&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dessailly, Benoît H.
AU - Nair, Rajesh
AU - Jaroszewski, Lukasz
AU - Fajardo, J. Eduardo
AU - Kouranov, Andrei
AU - Lee, David
AU - Fiser, Andras
AU - Godzik, Adam
AU - Rost, Burkhard
AU - Orengo, Christine
T1 - PSI-2: Structural Genomics to Cover Protein Domain Family Space
JO - Structure
JF - Structure
Y1 - 2009/06/10/
VL - 17
IS - 6
M3 - Article
SP - 869
EP - 881
SN - 09692126
AB - Summary: One major objective of structural genomics efforts, including the NIH-funded Protein Structure Initiative (PSI), has been to increase the structural coverage of protein sequence space. Here, we present the target selection strategy used during the second phase of PSI (PSI-2). This strategy, jointly devised by the bioinformatics groups associated with the PSI-2 large-scale production centers, targets representatives from large, structurally uncharacterized protein domain families, and from structurally uncharacterized subfamilies in very large and diverse families with incomplete structural coverage. These very large families are extremely diverse both structurally and functionally, and are highly overrepresented in known proteomes. On the basis of several metrics, we then discuss to what extent PSI-2, during its first 3 years, has increased the structural coverage of genomes, and contributed structural and functional novelty. Together, the results presented here suggest that PSI-2 is successfully meeting its objectives and provides useful insights into structural and functional space. [Copyright &y& Elsevier]
AB - Copyright of Structure is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN structure
KW - GENOMICS
KW - AMINO acid sequence
KW - BIOINFORMATICS
KW - PROTEOMICS
KW - PROTEINS
KW - NATIONAL Institutes of Health (U.S.)
N1 - Accession Number: 41583238; Dessailly, Benoît H. 1; Email Address: benoit@biochem.ucl.ac.uk Nair, Rajesh 2 Jaroszewski, Lukasz 3 Fajardo, J. Eduardo 4 Kouranov, Andrei 5 Lee, David 1 Fiser, Andras 4 Godzik, Adam 3 Rost, Burkhard 6 Orengo, Christine 1; Affiliation: 1: Department of Structural and Molecular Biology, University College of London, London WC1E 6BT, UK 2: Center for Devices and Radiological Health, Food and Drug Administration, 1350 Piccard Drive, Rockville, MD 20850, USA 3: The Burnham Institute, La Jolla, CA 92037, USA 4: Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA 5: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA 6: Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics (C2B2), and Northeast Structural Genomics Consortium (NESG), Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA; Source Info: Jun2009, Vol. 17 Issue 6, p869; Subject Term: PROTEIN structure; Subject Term: GENOMICS; Subject Term: AMINO acid sequence; Subject Term: BIOINFORMATICS; Subject Term: PROTEOMICS; Author-Supplied Keyword: PROTEINS; Company/Entity: NATIONAL Institutes of Health (U.S.); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.str.2009.03.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41583238&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Hamburg, Margaret A.
AU - Sharfstein, Joshua M.
T1 - The FDA as a Public Health Agency.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/06/11/
VL - 360
IS - 24
M3 - Editorial
SP - 2493
EP - 2495
SN - 00284793
AB - The author looks at the responsibilities of the U.S. Food and Drug Administration (FDA) as a public health agency. She argues that the agency has been responsible for oversight of more than 2 trillion U.S. dollars in medical products and other consumer goods. She states that under U.S. President Barack Obama, the agency's purpose is to fulfill society's interest in assuring the conditions in which citizens can be healthy. She notes that the public health role of the agency is reflected in the urgent need to develop a vaccine against the H1N1 virus.
KW - GOVERNMENT agencies -- United States
KW - PUBLIC health -- United States
KW - DRUG development
KW - SWINE influenza -- Prevention
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - OBAMA, Barack, 1961-
N1 - Accession Number: 41425962; Hamburg, Margaret A. 1 Sharfstein, Joshua M. 2; Affiliation: 1: commissioner, Food and Drug Administration, Silver Spring, MD 2: principal deputy commissioner, Food and Drug Administration, Silver Spring, MD; Source Info: 6/11/2009, Vol. 360 Issue 24, p2493; Subject Term: GOVERNMENT agencies -- United States; Subject Term: PUBLIC health -- United States; Subject Term: DRUG development; Subject Term: SWINE influenza -- Prevention; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); People: OBAMA, Barack, 1961-; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1822
L3 - 10.1056/NEJMp0903764
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41425962&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105369361
T1 - Screening for high blood pressure.
AU - Lin K
Y1 - 2009/06/15/
N1 - Accession Number: 105369361. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Health Screening
KW - Hypertension -- Diagnosis
KW - Adult
KW - Hypertension -- Therapy
KW - Male
KW - Practice Guidelines
SP - 1093
EP - 1093
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 79
IS - 12
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Agency for Healthcare Research and Quality, Bethesda, MA, USA.
U2 - PMID: 19530641.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105369361&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - MacDonald, Leslie A.
AU - Cohen, Alex
AU - Baron, Sherry
AU - Burchfiel, Cecil M.
T1 - Occupation as Socioeconomic Status or Environmental Exposure? A Survey of Practice Among Population-based Cardiovascular Studies in the United States.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/06/15/
VL - 169
IS - 12
M3 - Article
SP - 1411
EP - 1421
SN - 00029262
AB - Decisions about how occupation is used in epidemiologic research can affect conclusions about the importance of socioeconomic and environmental factors in explaining disparities for outcomes such as cardiovascular disease. A review of practices in the collection and use of occupational data was conducted among population-based cardiovascular studies in the United States. Studies were identified for review from the National Heart, Lung, and Blood Institute website and the biomedical database, Computer Retrieval of Information on Scientific Projects, by use of selected criteria. Data collection instruments and study publications were retrieved and reviewed for 30 of 33 studies (91%). Most of the studies (83%) collected at least descriptive occupational data, and more than half (60%) collected data on workplace hazards. The reviewed studies produced 80 publications in which occupational data were used in analyses, most often as an indicator of socioeconomic status. Authors rarely acknowledged known conceptual and empirical links among socioeconomic status, employment stability, and working conditions. Underutilization of data on workplace conditions was found. Existing data could be used more effectively to examine the contribution of work-related social and environmental conditions to the development of modifiable cardiovascular disease through multiple pathways. [ABSTRACT FROM PUBLISHER]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - CARDIOVASCULAR diseases
KW - OUTCOME assessment (Medical care)
KW - SOCIAL status
KW - POPULATION
KW - UNITED States
KW - cardiovascular diseases
KW - environment and public health
KW - epidemiologic research design
KW - occupations
KW - social class
N1 - Accession Number: 44356087; MacDonald, Leslie A. 1; Email Address: lmacdonald@cdc.gov Cohen, Alex Baron, Sherry Burchfiel, Cecil M.; Affiliation: 1: Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati, OH 45226-1998; Source Info: Jun2009, Vol. 169 Issue 12, p1411; Subject Term: EPIDEMIOLOGY; Subject Term: CARDIOVASCULAR diseases; Subject Term: OUTCOME assessment (Medical care); Subject Term: SOCIAL status; Subject Term: POPULATION; Subject Term: UNITED States; Author-Supplied Keyword: cardiovascular diseases; Author-Supplied Keyword: environment and public health; Author-Supplied Keyword: epidemiologic research design; Author-Supplied Keyword: occupations; Author-Supplied Keyword: social class; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1093/aje/kwp082
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44356087&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MacDonald, Leslie A.
AU - Cohen, Alex
AU - Baron, Sherry
AU - Burchfiel, Cecil M.
T1 - MacDonald et al. Respond to “Search for Preventable Causes of Cardiovascular Disease”.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/06/15/
VL - 169
IS - 12
M3 - Opinion
SP - 1426
EP - 1427
SN - 00029262
AB - The authors present their views on the commentary "The Search for Preventable Causes of Cardiovascular Disease," by M. Cullen. They reiterates that their review of practices in the collection and use of occupational data in population-base cardiovascular studies is aimed at ascertaining the use of socioeconomic status in health research. They believe that population-based cohorts have been often larger and more diverse.
KW - COHORT analysis
KW - CARDIOVASCULAR diseases
KW - PREVENTIVE medicine
KW - SOCIAL status
KW - INDUSTRIAL hygiene
KW - OCCUPATIONAL medicine
N1 - Accession Number: 44356092; MacDonald, Leslie A. 1; Email Address: lmacdonald@cdc.gov Cohen, Alex Baron, Sherry Burchfiel, Cecil M.; Affiliation: 1: Industry-wide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-15, Cincinnati, OH 45226-1998; Source Info: Jun2009, Vol. 169 Issue 12, p1426; Subject Term: COHORT analysis; Subject Term: CARDIOVASCULAR diseases; Subject Term: PREVENTIVE medicine; Subject Term: SOCIAL status; Subject Term: INDUSTRIAL hygiene; Subject Term: OCCUPATIONAL medicine; Number of Pages: 2p; Document Type: Opinion
L3 - 10.1093/aje/kwp080
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44356092&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ruder, Avima M.
AU - Carreón, Tania
AU - Butler, Mary Ann
AU - Calvert, Geoffrey M.
AU - Davis-King, Karen E.
AU - Waters, Martha A.
AU - Schulte, Paul A.
AU - Mandel, Jack S.
AU - Morton, Roscoe F.
AU - Reding, Douglas J.
AU - Rosenman, Kenneth D.
T1 - Exposure to Farm Crops, Livestock, and Farm Tasks and Risk of Glioma.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/06/15/
VL - 169
IS - 12
M3 - Article
SP - 1479
EP - 1491
SN - 00029262
AB - Some studies of brain cancer have found an excess risk for farmers. The National Institute for Occupational Safety and Health previously found no increased glioma risk for ever (vs. never) being exposed to pesticides on a farm among 798 cases and 1,175 population-based controls (adult (ages 18–80 years) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin). For this analysis (1995–1998), 288 cases and 474 controls (or their proxies) who had lived on farms at age 18 years or after were asked about exposure to crops, livestock, and farm tasks. Logistic regression was used to calculate odds ratios adjusted for age, age group, sex, state, and education. Never immediately washing up (adjusted odds ratio (OR) = 3.08, 95% confidence interval (CI): 1.78, 5.34) or changing clothes (OR = 2.84, 95% CI: 1.04, 7.78) after applying pesticides was associated with increased glioma risk. Living on a farm on which corn, oats, soybeans, or hogs were raised was associated with decreased risk (corn—OR = 0.37, 95% CI: 0.20, 0.69; oats—OR = 0.63, 95% CI: 0.40, 1.00; soybeans—OR = 0.69, 95% CI: 0.48, 0.98; hogs—OR = 0.63, 95% CI: 0.43, 0.93). Negative associations may be due to chance or a “healthy farmer” effect. Farmers’ increased risk of glioma may be due to work practices, other activities, or an inverse association with allergies (reported by other investigators). [ABSTRACT FROM PUBLISHER]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BRAIN cancer
KW - FARMERS
KW - PESTICIDES
KW - CONFIDENCE intervals
KW - IOWA
KW - MICHIGAN
KW - MINNESOTA
KW - agricultural
KW - Agriculture
KW - animals
KW - animals, domestic
KW - brain neoplasms
KW - case-control studies
KW - crops
KW - crops, agricultural
KW - domestic
KW - glioma
KW - occupational exposure
KW - pesticides
N1 - Accession Number: 44356086; Ruder, Avima M. 1; Email Address: amr2@cdc.gov Carreón, Tania Butler, Mary Ann Calvert, Geoffrey M. Davis-King, Karen E. Waters, Martha A. Schulte, Paul A. Mandel, Jack S. Morton, Roscoe F. Reding, Douglas J. Rosenman, Kenneth D.; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop R-16, Cincinnati, OH 45226; Source Info: Jun2009, Vol. 169 Issue 12, p1479; Subject Term: BRAIN cancer; Subject Term: FARMERS; Subject Term: PESTICIDES; Subject Term: CONFIDENCE intervals; Subject Term: IOWA; Subject Term: MICHIGAN; Subject Term: MINNESOTA; Author-Supplied Keyword: agricultural; Author-Supplied Keyword: Agriculture; Author-Supplied Keyword: animals; Author-Supplied Keyword: animals, domestic; Author-Supplied Keyword: brain neoplasms; Author-Supplied Keyword: case-control studies; Author-Supplied Keyword: crops; Author-Supplied Keyword: crops, agricultural; Author-Supplied Keyword: domestic; Author-Supplied Keyword: glioma; Author-Supplied Keyword: occupational exposure; Author-Supplied Keyword: pesticides; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 13p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1093/aje/kwp075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44356086&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105351989
T1 - Occupation as socioeconomic status or environmental exposure? A survey of practice among population-based cardiovascular studies in the United States.
AU - MacDonald LA
AU - Cohen A
AU - Baron S
AU - Burchfiel CM
Y1 - 2009/06/15/
N1 - Accession Number: 105351989. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Cardiovascular Diseases -- Epidemiology
KW - Occupational Exposure -- Adverse Effects
KW - Occupational Health
KW - Public Health
KW - Social Class
KW - Cardiovascular Diseases -- Etiology
KW - Cardiovascular Diseases -- Prevention and Control
KW - Epidemiological Research
KW - Risk Factors
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 1411
EP - 1421
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 169
IS - 12
PB - Oxford University Press / USA
AB - Decisions about how occupation is used in epidemiologic research can affect conclusions about the importance of socioeconomic and environmental factors in explaining disparities for outcomes such as cardiovascular disease. A review of practices in the collection and use of occupational data was conducted among population-based cardiovascular studies in the United States. Studies were identified for review from the National Heart, Lung, and Blood Institute website and the biomedical database, Computer Retrieval of Information on Scientific Projects, by use of selected criteria. Data collection instruments and study publications were retrieved and reviewed for 30 of 33 studies (91%). Most of the studies (83%) collected at least descriptive occupational data, and more than half (60%) collected data on workplace hazards. The reviewed studies produced 80 publications in which occupational data were used in analyses, most often as an indicator of socioeconomic status. Authors rarely acknowledged known conceptual and empirical links among socioeconomic status, employment stability, and working conditions. Underutilization of data on workplace conditions was found. Existing data could be used more effectively to examine the contribution of work-related social and environmental conditions to the development of modifiable cardiovascular disease through multiple pathways.
SN - 0002-9262
AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. lmacdonald@cdc.gov
U2 - PMID: 19429878.
DO - aje/kwp082
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105351989&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105351991
T1 - MacDonald et al. Respond to 'search for preventable causes of cardiovascular disease'.
AU - MacDonald LA
AU - Cohen A
AU - Baron S
AU - Burchfiel CM
Y1 - 2009/06/15/
N1 - Accession Number: 105351991. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Cardiovascular Diseases -- Prevention and Control
KW - Occupational Exposure
KW - Occupational Health
KW - Public Health
KW - Cardiovascular Diseases -- Epidemiology
KW - Epidemiological Research
KW - Incidence
KW - Risk Factors
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 1426
EP - 1427
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 169
IS - 12
PB - Oxford University Press / USA
SN - 0002-9262
AD - Industry-wide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. lmacdonald@cdc.gov
U2 - PMID: 19429880.
DO - aje/kwp080
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105351991&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105351984
T1 - Exposure to farm crops, livestock, and farm tasks and risk of glioma: the Upper Midwest Health Study.
AU - Ruder AM
AU - Carreón T
AU - Butler MA
AU - Calvert GM
AU - Davis-King KE
AU - Waters MA
AU - Schulte PA
AU - Mandel JS
AU - Morton RF
AU - Reding DJ
AU - Rosenman KD
Y1 - 2009/06/15/
N1 - Accession Number: 105351984. Corporate Author: Brain Cancer Collaborative Study Group. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7910653.
KW - Brain Neoplasms -- Epidemiology
KW - Glioma -- Epidemiology
KW - Occupational Diseases -- Epidemiology
KW - Occupational Exposure -- Adverse Effects
KW - Pesticides
KW - Plants, Edible
KW - Adolescence
KW - Adult
KW - Aged
KW - Agriculture -- Methods
KW - Agriculture -- Statistics and Numerical Data
KW - Animals
KW - Brain Neoplasms -- Chemically Induced
KW - Brain Neoplasms -- Etiology
KW - Case Control Studies
KW - Confidence Intervals
KW - Female
KW - Glioma -- Chemically Induced
KW - Glioma -- Etiology
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Etiology
KW - Occupational Diseases
KW - Odds Ratio
KW - Organic Chemicals
KW - Pets
KW - Questionnaires
KW - Risk Assessment
KW - Risk Factors
KW - United States
KW - Human
SP - 1479
EP - 1491
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
JA - AM J EPIDEMIOL
VL - 169
IS - 12
PB - Oxford University Press / USA
AB - Some studies of brain cancer have found an excess risk for farmers. The National Institute for Occupational Safety and Health previously found no increased glioma risk for ever (vs. never) being exposed to pesticides on a farm among 798 cases and 1,175 population-based controls (adult (ages 18-80 years) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin). For this analysis (1995-1998), 288 cases and 474 controls (or their proxies) who had lived on farms at age 18 years or after were asked about exposure to crops, livestock, and farm tasks. Logistic regression was used to calculate odds ratios adjusted for age, age group, sex, state, and education. Never immediately washing up (adjusted odds ratio (OR) = 3.08, 95% confidence interval (CI): 1.78, 5.34) or changing clothes (OR = 2.84, 95% CI: 1.04, 7.78) after applying pesticides was associated with increased glioma risk. Living on a farm on which corn, oats, soybeans, or hogs were raised was associated with decreased risk (corn-OR = 0.37, 95% CI: 0.20, 0.69; oats-OR = 0.63, 95% CI: 0.40, 1.00; soybeans-OR = 0.69, 95% CI: 0.48, 0.98; hogs-OR = 0.63, 95% CI: 0.43, 0.93). Negative associations may be due to chance or a 'healthy farmer' effect. Farmers' increased risk of glioma may be due to work practices, other activities, or an inverse association with allergies (reported by other investigators).
SN - 0002-9262
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. amr2@cdc.gov
U2 - PMID: 19403843.
DO - aje/kwp075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105351984&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - So Young Um
AU - Myeon Woo Chung
AU - Kyu-Bong Kim
AU - Seon Hwa Kim
AU - Ji Seon Oh
AU - Hye Young Oh
AU - Hwa Jeong Lee
AU - Ki Hwan Choi
T1 - Pattern Recognition Analysis for the Prediction of Adverse Effects by Nonsteroidal Anti-Inflammatory Drugs Using 1H NMR-Based Metabolomics in Rats.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2009/06/15/
VL - 81
IS - 12
M3 - Article
SP - 4734
EP - 4741
SN - 00032700
AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat rheumatoid arthritis, osteoarthritis, acute pain, and fever. However, NSAIDs have side effects that include gastric erosions, ulceration, bleeding, and perforation, etc. Selective cyclooxygenase (COX)-2 inhibitors have been developed to avoid the adverse drug reaction of traditional NSAIDs. The COX-2 inhibitors have a different mechanism of action from nonselective COX inhibitors. In this study, pattern recognition analysis of the 1H nuclear magnetic resonance (NMR) spectra of urine was performed to develop surrogate biomarkers related to the gastrointestinal (GI) damage induced by NSAIDs in rats. Urine was collected for 5 h after administering the following NSAIDs at high doses: celecoxib (133 mg kg-1, po), a COX-2-selective inhibitor; and indomethacin (25 mg kg-1, po) or ibuprofen (800 mg kg-1, po), nonselective COX inhibitors. The urine was analyzed using 600 M 1H NMR for spectral binning and targeted profiling. The level of gastric damage in each animal was also determined. Indomethacin and ibuprofen caused severe gastric damage, but no lesions were observed in the celecoxib-treated rats. The 1H NMR urine spectra were divided into spectral bins (0.04 ppm) for global profiling, and 36 endogenous metabolites were assigned for targeted profiling. Multivariate data analyses were carried out to recognize the spectral pattern of endogenous metabolites related to NSAIDs using partial least-squares discrimination analysis (PLS-DA). There were different clusterings of 1H NMR spectra according to the gastric damage scores in global profiling. in targeted profiling, a few endogenous metabolites of allantoine, taurine, and dimethylamine were selected as putative biomarkers for the gastric damage induced by NSAIDs. The results of global and targeted profihings suggest that the gastric damage induced by NSAIDs can be screened in the preclinical stage of drug development using a current metabolomics study. In addition, the putative biomarkers might also be useful for predicting the risk of adverse effects caused by NSAIDs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONSTEROIDAL anti-inflammatory agents
KW - RHEUMATOID arthritis
KW - OSTEOARTHRITIS
KW - CYCLOOXYGENASE 2 -- Inhibitors
KW - NUCLEAR magnetic resonance
KW - BIOCHEMICAL markers
KW - INDOMETHACIN
KW - ANALYTICAL chemistry
N1 - Accession Number: 42988179; So Young Um 1,2 Myeon Woo Chung 1 Kyu-Bong Kim 1 Seon Hwa Kim 1 Ji Seon Oh 1 Hye Young Oh 1 Hwa Jeong Lee 1; Email Address: hwalee@ewha.ac.kr Ki Hwan Choi 1; Email Address: hyokwa@kfda.go.kr; Affiliation: 1: Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-Ku, Seoul, Korea 2: Division of Life and Pharmaceutical Science, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-Ku, Seoul, South Korea; Source Info: 6/15/2009, Vol. 81 Issue 12, p4734; Subject Term: NONSTEROIDAL anti-inflammatory agents; Subject Term: RHEUMATOID arthritis; Subject Term: OSTEOARTHRITIS; Subject Term: CYCLOOXYGENASE 2 -- Inhibitors; Subject Term: NUCLEAR magnetic resonance; Subject Term: BIOCHEMICAL markers; Subject Term: INDOMETHACIN; Subject Term: ANALYTICAL chemistry; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 8p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42988179&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Olekhnovich, Igor N.
AU - Goodwin, Avery
AU - Hoffman, Paul S.
T1 - Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.
JO - FEBS Journal
JF - FEBS Journal
Y1 - 2009/06/15/
VL - 276
IS - 12
M3 - Article
SP - 3354
EP - 3364
PB - Wiley-Blackwell
SN - 1742464X
AB - Metronidazole (MTZ) is widely used in combination therapies against the human gastric pathogen Helicobacter pylori. Resistance to this drug is common among clinical isolates and results from loss-of-function mutations in rdxA, which encodes an oxygen-insensitive nitroreductase. The RdxA-associated MTZ-reductase activity of H. pylori is lost upon cell disruption. Here we provide a mechanistic explanation for this phenomenon. Under aerobic conditions, His6-tagged RdxA protein (purified from Escherichia coli), catalyzed NAD(P)H-dependent reductions of nitroaromatic and quinone substrates including nitrofurazone, nitrofurantoin, furazolidone, CB1954 and 1,4-benzoquinone, but not MTZ. Unlike other nitroreductases, His6–RdxA exhibited potent NAD(P)H-oxidase activity ( kcat = 2.8 s−1) which suggested two possible explanations for the role of oxygen in MTZ reduction: (a) NAD(P)H-oxidase activity promotes cellular hypoxia (nonspecific reduction of MTZ), and (b) molecular oxygen out-competes MTZ for reducing equivalents. The first hypothesis was eliminated upon finding that rdxA expression, although increasing MTZ toxicity in both E. coli and H. pylori constructs, did not increase paraquat toxicity, even though both are of similar redox potential. The second hypothesis was confirmed by demonstrating NAD(P)H-dependent MTZ-reductase activity (apparent Km = 122 ± 58 μm, kcat = 0.24 s−1) under strictly anaerobic conditions. The MTZ-reductase activity of RdxA was 60 times greater than for NfsB ( E. coli NTR), but 10 times lower than the NADPH-oxidase activity. Whether molecular oxygen directly competes with MTZ or alters the redox state of the FMN cofactors is discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of FEBS Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NAD(P)H dehydrogenases
KW - OXIDASES
KW - METRONIDAZOLE
KW - HELICOBACTER pylori
KW - NITROAROMATIC compounds
KW - ANTIBACTERIAL agents
KW - flavoprotein
KW - Helicobacter
KW - metronidazole
KW - NAD(P)H oxidase
KW - nitroreductase
N1 - Accession Number: 40076404; Olekhnovich, Igor N. 1,2 Goodwin, Avery 3 Hoffman, Paul S. 1,2; Email Address: psh2n@virginia.edu; Affiliation: 1: Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA 2: Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA, USA 3: Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, USA; Source Info: Jun2009, Vol. 276 Issue 12, p3354; Subject Term: NAD(P)H dehydrogenases; Subject Term: OXIDASES; Subject Term: METRONIDAZOLE; Subject Term: HELICOBACTER pylori; Subject Term: NITROAROMATIC compounds; Subject Term: ANTIBACTERIAL agents; Author-Supplied Keyword: flavoprotein; Author-Supplied Keyword: Helicobacter; Author-Supplied Keyword: metronidazole; Author-Supplied Keyword: NAD(P)H oxidase; Author-Supplied Keyword: nitroreductase; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 11p; Illustrations: 1 Diagram, 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1742-4658.2009.07060.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40076404&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Singh, Diljeet K.
AU - Anastos, Kathryn
AU - Hoover, Donald R.
AU - Burk, Robert D.
AU - Qiuhu Shi
AU - Ngendahayo, Louis
AU - Mutimura, Eugene
AU - Cajigas, Antonio
AU - Bigirimani, Venerand
AU - Xiaotao Cai
AU - Rwamwejo, Janvier
AU - Vuolo, Magalis
AU - Cohen, Mardge
AU - Castle, Philip E.
T1 - Human Papillomavirus Infection and Cervical Cytology in HIV-Infected and HIV-Uninfected Rwandan Women.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/06/15/
VL - 199
IS - 12
M3 - Article
SP - 1851
EP - 1861
SN - 00221899
AB - Background. Data on human papillomavirus (HPV) prevalence are essential for developing cost-effective cervical cancer prevention programs. Methods. In 2005, 710 human immunodeficiency virus (HIV)-positive and 226 HIV-negative Rwandan women enrolled in an observational prospective cohort study. Sociodemographic data, CD4+ cell counts, and cervical specimens were obtained. Cervicovaginal lavage specimens were collected from each woman and tested for >40 HPV types by a polymerase chain reaction assay; HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 were considered primary carcinogenic HPV types. Results. The prevalence of HPV was higher in HIV-positive women than in HIV-negative women in all age groups. Among HIV-infected women, 69% were positive for ⩾1 HPV type, 46% for a carcinogenic HPV type, and 10% for HPV-16.HPV prevalence peaked at 75% in the HIV-positive women aged 25-34 years and then declined with age to 37.5% in those ⩾55 years old (Ptrend < .001). A significant trend of higher prevalence of HPV and carcinogenic HPV with lower CD4+ cell counts and increasing cytologic severity was seen among HIV-positive women. Conclusions. We found a higher prevalence of HPV infection in HIV-positive than in HIV-negative Rwandan women, and the prevalence of HPV and carcinogenic HPV infection decreased with age. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PAPILLOMAVIRUS diseases
KW - CERVICAL cancer
KW - HIV (Viruses)
KW - ETHNOLOGY
KW - HIV-positive women
KW - POLYMERASE chain reaction
KW - CARCINOGENS
KW - HIV infections
KW - RWANDA
N1 - Accession Number: 41534722; Singh, Diljeet K. 1; Email Address: dsingh2@nmff.org Anastos, Kathryn 2,3 Hoover, Donald R. 4 Burk, Robert D. 3 Qiuhu Shi 5 Ngendahayo, Louis 6 Mutimura, Eugene 7 Cajigas, Antonio 2,3 Bigirimani, Venerand 8 Xiaotao Cai 9 Rwamwejo, Janvier 8 Vuolo, Magalis 2,3 Cohen, Mardge 10 Castle, Philip E. 11; Affiliation: 1: Division of Gynecologic Oncology, Feinberg School of Medicine, Northwestern University, Illinois 2: Montefiore Medical Center, Bronx, New York 3: Albert Einstein College of Medicine, Bronx, New York 4: Department of Statistics and Biostatistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, New Jersey 5: New York Medical College, Valhalla, New York 6: National University of Rwanda, Butare, Rwanda 7: Women's Equity in Access to Care and Treatment, Kigali, Rwanda 8: King Faisal Hospital, Kigali, Rwanda 9: Data Solutions, Bronx, New York 10: Cook County Hospital, Chicago, Illinois 11: National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland; Source Info: 6/15/2009, Vol. 199 Issue 12, p1851; Subject Term: PAPILLOMAVIRUS diseases; Subject Term: CERVICAL cancer; Subject Term: HIV (Viruses); Subject Term: ETHNOLOGY; Subject Term: HIV-positive women; Subject Term: POLYMERASE chain reaction; Subject Term: CARCINOGENS; Subject Term: HIV infections; Subject Term: RWANDA; Number of Pages: 11p; Document Type: Article
L3 - 10.1086/599123
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhang, Xichen
AU - Hashemi, Shahreyar Shar
AU - Yousefi, Morvarid
AU - Gao, Chunling
AU - Sheng, Joy
AU - Ni, Jinsong
AU - Wang, Wan
AU - Mason, Jeffrey
AU - Man, Yan-gao
T1 - Atypical E-cadherin expression in cell clusters overlying focally disrupted mammary myoepithelial cell layers: Implications for tumor cell motility and invasion
JO - Pathology - Research & Practice
JF - Pathology - Research & Practice
Y1 - 2009/06/15/
VL - 205
IS - 6
M3 - Article
SP - 375
EP - 385
SN - 03440338
AB - Abstract: Our recent studies showed that cell clusters overlying focal myoepithelial cell layer disruptions (FMCLD) had a significantly higher rate of ER negativity, genetic instabilities, and expression of invasion-related genes than adjacent cells within the same duct. This study attempted to determine if these cells would show aberrant E-cadherin expression, which imparts greater propensity for cell motility and invasion. Consecutive sections from breast tumors with a high frequency of FMCLD were double-immunostained for E-cadherin and a panel of related markers. The E-cadherin mRNA levels in cells overlying FMCLD and adjacent cells within the same duct were compared using real-time PCR. Nearly all the cell clusters overlying FMCLD were strongly immunoreactive for E-cadherin, whereas their adjacent counterparts within the same duct were largely negative. Cell clusters overlying FMCLD were generally arranged as tongue-like projections, “puncturing” deep into the stroma or tube-like structures that often contained red blood cells. The sub-cellular localization of E-cadherin in the above structures, however, was primarily cytoplasmic. The mRNA level of E-cadherin in cell clusters overlying FMCLD was significantly higher than that in adjacent cells within the same duct. These findings suggest that aberrant expression of E-cadherin may contribute to cell motility and invasion. [Copyright &y& Elsevier]
AB - Copyright of Pathology - Research & Practice is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER cells
KW - IMMUNOHISTOCHEMISTRY
KW - MESSENGER RNA
KW - BREAST cancer
KW - Breast cancer invasion
KW - Double immunohistochemistry
KW - E-cadherin
KW - Epithelial-stromal-interaction
KW - Myoepithelial cell layer disruption
N1 - Accession Number: 38807498; Zhang, Xichen 1 Hashemi, Shahreyar Shar 2 Yousefi, Morvarid 2 Gao, Chunling 3 Sheng, Joy 4 Ni, Jinsong 5 Wang, Wan 6 Mason, Jeffrey 7 Man, Yan-gao 8; Email Address: man@afip.osd.mil; Affiliation: 1: College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China 2: Departments of Surgery and Internal Medicine, Staten Island University Hospital, NY, USA 3: Division of Monoclonal Antibodies, Food and Drug Administration, Bethesda, MD, USA 4: Real-time PCR Technical Support Department, Applied Biosystems, Foster City, CA, USA 5: Norman Bethune College of Medical Science, Jilin University, Changchun, Jilin, China 6: Breast and Thyroid Surgery Department, China-Japan Union Hospital, Changchun, Jilin, China 7: Department of Biophysics, Armed Forces Institute of Pathology, Rockville, MD, USA 8: Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825, 16th Street, NW, Washington, DC 20306-6000, USA; Source Info: Jun2009, Vol. 205 Issue 6, p375; Subject Term: CANCER cells; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: MESSENGER RNA; Subject Term: BREAST cancer; Author-Supplied Keyword: Breast cancer invasion; Author-Supplied Keyword: Double immunohistochemistry; Author-Supplied Keyword: E-cadherin; Author-Supplied Keyword: Epithelial-stromal-interaction; Author-Supplied Keyword: Myoepithelial cell layer disruption; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.prp.2008.08.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=38807498&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lin, Kenneth
AU - Vickery, John
T1 - Screening for Hepatitis B Virus Infection in Pregnant Women: Evidence for the U.S. Preventive Services Task Force Reaffirmation Recommendation Statement.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/06/16/
VL - 150
IS - 12
M3 - Article
SP - 874
EP - 876
SN - 00034819
AB - Background: Screening for hepatitis B virus (HBV) infection in pregnant women to identify newborns who will require prophylaxis against perinatal infection is a well-established, evidence-based standard of current medical practice. In 2004, the U.S. Preventive Services Task Force (USPSTF) recommended universal screening of pregnant women for HBV infection at the first prenatal visit. Purpose: To search for large, high-quality studies related to hepatitis B screening in pregnancy that have been published since the 2004 USPSTF recommendation. Data Sources: English-language studies indexed in PubMed and the Cochrane Database of Systematic Reviews and published between 1 January 2001 and 5 March 2008. Study Selection: For benefits of screening and newborn prophylaxis, we included systematic reviews; meta-analyses; and randomized, controlled trials. For harms of screening, we included systematic reviews; meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases. Abstracts and full articles were independently reviewed for inclusion by both reviewers. Data Extraction: Data on the benefits of screening, including benefits of hepatitis B immune globulin and hepatitis B vaccine prophylaxis of newborns of hepatitis B surface antigen-positive mothers, were extracted by 1 reviewer. Data Synthesis: No new studies met inclusion criteria. A 2006 systematic review of randomized, controlled trials found that newborn prophylaxis reduced perinatal transmission of HBV infection; all relevant trials were published in 1996 or earlier. Limitation: The focused search strategy, which was restricted to English-language articles, may have missed some smaller studies or new research published in languages other than English. Conclusion: No new evidence was found on the benefits or harms of screening for HBV infection in pregnant women. Previously published randomized trials support the 2004 USPSTF recommendation for screening. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B virus
KW - VIRUS diseases
KW - PREGNANCY
KW - PREGNANT women
KW - PRENATAL care
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 41990404; Lin, Kenneth 1; Email Address: Kenneth.Lin@ahrq.hhs.gov Vickery, John 1; Affiliation: 1: Agency for Healthcare Research and Quality, Rockville, Maryland; Source Info: 6/16/2009, Vol. 150 Issue 12, p874; Subject Term: HEPATITIS B virus; Subject Term: VIRUS diseases; Subject Term: PREGNANCY; Subject Term: PREGNANT women; Subject Term: PRENATAL care; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105097577
T1 - Screening for hepatitis B virus infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement.
AU - Lin K
AU - Vickery J
Y1 - 2009/06/16/
N1 - Accession Number: 105097577. Language: English. Entry Date: 20100924. Revision Date: 20150711. Publication Type: Journal Article; research; systematic review. Journal Subset: Biomedical; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Obstetric Care. NLM UID: 0372351.
KW - Disease Transmission, Vertical -- Prevention and Control
KW - Health Screening -- Adverse Effects
KW - Hepatitis B -- Transmission
KW - Pregnancy Complications, Infectious -- Diagnosis
KW - Pregnancy Complications, Infectious -- Prevention and Control
KW - Prenatal Care
KW - Cochrane Library
KW - Female
KW - Hepatitis B -- Diagnosis
KW - Hepatitis B -- Prevention and Control
KW - Human
KW - Immunoassay -- Adverse Effects
KW - Medical Practice, Evidence-Based
KW - Pregnancy
KW - PubMed
KW - Systematic Review
SP - 874
EP - 876
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
JA - ANN INTERN MED
VL - 150
IS - 12
CY - Philadelphia, Pennsylvania
PB - American College of Physicians
AB - BACKGROUND: Screening for hepatitis B virus (HBV) infection in pregnant women to identify newborns who will require prophylaxis against perinatal infection is a well-established, evidence-based standard of current medical practice. In 2004, the U.S. Preventive Services Task Force (USPSTF) recommended universal screening of pregnant women for HBV infection at the first prenatal visit. PURPOSE: To search for large, high-quality studies related to hepatitis B screening in pregnancy that have been published since the 2004 USPSTF recommendation. DATA SOURCES: English-language studies indexed in PubMed and the Cochrane Database of Systematic Reviews and published between 1 January 2001 and 5 March 2008. STUDY SELECTION: For benefits of screening and newborn prophylaxis, we included systematic reviews; meta-analyses; and randomized, controlled trials. For harms of screening, we included systematic reviews; meta-analyses; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases. Abstracts and full articles were independently reviewed for inclusion by both reviewers. DATA EXTRACTION: Data on the benefits of screening, including benefits of hepatitis B immune globulin and hepatitis B vaccine prophylaxis of newborns of hepatitis B surface antigen-positive mothers, were extracted by 1 reviewer. DATA SYNTHESIS: No new studies met inclusion criteria. A 2006 systematic review of randomized, controlled trials found that newborn prophylaxis reduced perinatal transmission of HBV infection; all relevant trials were published in 1996 or earlier. LIMITATION: The focused search strategy, which was restricted to English-language articles, may have missed some smaller studies or new research published in languages other than English. CONCLUSION: No new evidence was found on the benefits or harms of screening for HBV infection in pregnant women. Previously published randomized trials support the 2004 USPSTF recommendation for screening.
SN - 0003-4819
AD - Center for Primary Care, Prevention and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Kenneth.Lin@ahrq.hhs.gov
U2 - PMID: 19528566.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kim, Min-Sun
AU - Park, Hee Ra
AU - Park, Mikyung
AU - Kim, So Jung
AU - Kwon, Mugil
AU - Yu, Byung Pal
AU - Chung, Hae Young
AU - Kim, Hyung Sik
AU - Kwack, Seung Jun
AU - Kang, Tae Seok
AU - Kim, Seung Hee
AU - Lee, Jaewon
T1 - Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis
JO - Toxicology
JF - Toxicology
Y1 - 2009/06/16/
VL - 260
IS - 1-3
M3 - Article
SP - 97
EP - 103
SN - 0300483X
AB - Abstract: 2,5-Hexanedione (HD), a metabolite of n-hexane, causes central and peripheral neuropathy leading to motor neuron deficits. Although chronic exposure to n-hexane is known to cause gradual sensorimotor neuropathy, there are no reports on the effects of low doses of HD on neurogenesis in the central nervous system. In the current study, we explored HD toxicity in murine neural progenitor cells (NPC), primary neuronal culture and young adult mice. HD (500nM∼50μM) dose-dependently suppressed NPC proliferation and cell viability, and also increased the production of reactive oxygen species (ROS). HD (10 or 50mg/kg for 2 weeks) inhibited hippocampal neuronal and NPC proliferation in 6-week-old male ICR mice, as measured by BrdU incorporation in the dentate gyrus, indicating HD impaired hippocampal neurogenesis. In addition, elevated microglial activation was observed in the hippocampal CA3 region and lateral ventricles of HD-treated mice. Lastly, HD dose-dependently decreased the viability of primary cultured neurons. Based on biochemical and histochemical evidence from both cell culture and HD-treated animals, the neurotoxic mechanisms by which HD inhibits NPC proliferation and hippocampal neurogenesis may relate to its ability to elicit an increased generation of deleterious ROS. [Copyright &y& Elsevier]
AB - Copyright of Toxicology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXICOLOGY
KW - HIPPOCAMPUS (Brain)
KW - DEVELOPMENTAL neurobiology
KW - HEXANE
KW - METABOLITES
KW - NERVOUS system -- Diseases
KW - MICE as laboratory animals
KW - MECHANISM of action (Biochemistry)
KW - 2,5-Hexanedione
KW - 2,5-hexanedione ( HD )
KW - central nerve system ( CNS )
KW - Hippocampal neurogenesis
KW - Neural progenitor cells
KW - neural progenitor cells ( NPC )
KW - reactive oxygen species ( ROS )
KW - subgranular zone ( SGZ )
N1 - Accession Number: 40116970; Kim, Min-Sun 1 Park, Hee Ra 1 Park, Mikyung 1 Kim, So Jung 1 Kwon, Mugil 2 Yu, Byung Pal 3 Chung, Hae Young 1 Kim, Hyung Sik 1 Kwack, Seung Jun 4 Kang, Tae Seok 4 Kim, Seung Hee 4 Lee, Jaewon 1; Email Address: neuron@pusan.ac.kr; Affiliation: 1: Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong-gu, Busan 609-735, Republic of Korea 2: Centural Research Center, Kunwha Pharmaceutical Co., Ltd., Kongju, 314-820 & Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan 570-749, Republic of Korea 3: Department of Physiology, University of Texas Health Science Center, San Antonio, TX, USA 4: National Institute of Toxicological Research, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyoung-gu, Seoul 122-704, Republic of Korea; Source Info: Jun2009, Vol. 260 Issue 1-3, p97; Subject Term: NEUROTOXICOLOGY; Subject Term: HIPPOCAMPUS (Brain); Subject Term: DEVELOPMENTAL neurobiology; Subject Term: HEXANE; Subject Term: METABOLITES; Subject Term: NERVOUS system -- Diseases; Subject Term: MICE as laboratory animals; Subject Term: MECHANISM of action (Biochemistry); Author-Supplied Keyword: 2,5-Hexanedione; Author-Supplied Keyword: 2,5-hexanedione ( HD ); Author-Supplied Keyword: central nerve system ( CNS ); Author-Supplied Keyword: Hippocampal neurogenesis; Author-Supplied Keyword: Neural progenitor cells; Author-Supplied Keyword: neural progenitor cells ( NPC ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: subgranular zone ( SGZ ); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.tox.2009.03.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Nanga, Ravi Prakash Reddy
AU - Brender, Jeffrey R.
AU - Jiadi Xu
AU - Hartman, Kevin
AU - Subramanian, Vivekanandan
AU - Ramamoorthy, Ayyalusamy
T1 - Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy.
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
Y1 - 2009/06/17/
VL - 131
IS - 23
M3 - Article
SP - 8252
EP - 8261
SN - 00027863
AB - Islet amyloid polypeptide (IAPP or amylin) is a 37-residue peptide hormone associated with glucose metabolism that is cosecreted with insulin by β-cells in the pancreas. Since human IAPP is a highly amyloidogenic peptide, it has been suggested that the formation of APP amyloid fibers is responsible for the death of β-cells during the early stages of type II diabetes. It has been hypothesized that transient membrane-bound α-helical structures of human IAPP are. precursors to the formation of these amyloid deposits. On the other hand, rat IAPP forms transient α-helical structures but does not progress further to form amyloid fibrils. To understand the nature of this intermediate state and the difference in toxicity between the rat and human versions of IAPP, we have solved the high-resolution structure of rat IAPP in the membrane-mimicking detergent micelles composed of dodecylphosphocholine. The structure is characterized by a helical region spanning the residues A5 to S23 and a disordered C-terminus. A distortion in the helix is seen at R18 and S19 that may be involved in receptor binding. Paramagnetic quenching NMR experiments indicate that rat APP is bound on the surface of the micelle, in agreement with other nontoxic forms of APP. A comparison to the detergent-bound structures of other APP variants indicates that the N-terminal region may play a crucial role in the self-association and toxicity of IAPP by controlling access to the putative dimerization interface on the hydrophobic face of the amphipathic helix. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Chemical Society is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AMYLOID
KW - POLYPEPTIDES
KW - NUCLEAR magnetic resonance spectroscopy
KW - PEPTIDE hormones
KW - DIABETES
KW - GLUCOSE
N1 - Accession Number: 42846726; Nanga, Ravi Prakash Reddy 1 Brender, Jeffrey R. 1 Jiadi Xu 1 Hartman, Kevin 1 Subramanian, Vivekanandan 2 Ramamoorthy, Ayyalusamy 1; Email Address: ramamoor@umich.edu; Affiliation: 1: Department of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109 2: Structural Biology/NMR Spectroscopy, U.S. Food and Drug Administration, Bethesda, Maryland 20892; Source Info: 6/17/2009, Vol. 131 Issue 23, p8252; Subject Term: AMYLOID; Subject Term: POLYPEPTIDES; Subject Term: NUCLEAR magnetic resonance spectroscopy; Subject Term: PEPTIDE hormones; Subject Term: DIABETES; Subject Term: GLUCOSE; Number of Pages: 10p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-10288-001
AN - 2009-10288-001
AU - Xin, Xiaonan
AU - Rabiner, Chana A.
AU - Mains, Richard E.
AU - Eipper, Betty A.
T1 - Kalirin12 interacts with dynamin.
JF - BMC Neuroscience
JO - BMC Neuroscience
JA - BMC Neurosci
Y1 - 2009/06/17/
VL - 10
CY - United Kingdom
PB - BioMed Central Limited
SN - 1471-2202
AD - Eipper, Betty A., Neuroscience Department, University of Connecticut Health Center, Farmington, CT, US
N1 - Accession Number: 2009-10288-001. PMID: 19534784 Partial author list: First Author & Affiliation: Xin, Xiaonan; Neuroscience Department, University of Connecticut Health Center, Farmington, CT, US. Release Date: 20090727. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Dendrites; Enzymes; Nucleotides; Proteins. Minor Descriptor: Rats. Classification: Neuropsychology & Neurology (2520). Population: Animal (20); Female (40). Methodology: Empirical Study; Quantitative Study. References Available: Y. ArtID: 61. Issue Publication Date: Jun 17, 2009. Publication History: First Posted Date: Jun 17, 2009; Accepted Date: Jun 17, 2009; First Submitted Date: Dec 23, 2008. Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Xin et al; licensee BioMed Central Ltd. 2009.
AB - Background: Guanine nucleotide exchange factors (GEFs) and their target Rho GTPases regulate cytoskeletal changes and membrane trafficking. Dynamin, a large force-generating GTPase, plays an essential role in membrane tubulation and fission in cells. Kalirin12, a neuronal RhoGEF, is found in growth cones early in development and in dendritic spines later in development. Results: The IgFn domain of Kalirin12, not present in other Kalirin isoforms, binds dynamin1 and dynamin2. An inactivating mutation in the GTPase domain of dynamin diminishes this interaction and the isolated GTPase domain of dynamin retains the ability to bind Kalirin12. Co-immunoprecipitation demonstrates an interaction of Kalirin12 and dynamin2 in embryonic brain. Purified recombinant Kalirin-IgFn domain inhibits the ability of purified rat brain dynamin to oligomerize in response to the presence of liposomes containing phosphatidylinositol-4,5-bisphosphate. Consistent with this, expression of exogenous Kalirin12 or its IgFn domain in PC12 cells disrupts clathrin-mediated transferrin endocytosis. Similarly, expression of exogenous Kalirin12 disrupts transferrin endocytosis in cortical neurons. Expression of Kalirin7, a shorter isoform which lacks the IgFn domain, was previously shown to inhibit clathrin-mediated endocytosis; the GTPase domain of dynamin does not interact with Kalirin7. Conclusion: Kalirin12 may play a role in coordinating Rho GTPase-mediated changes in the actin cytoskeleton with dynamin-mediated changes in membrane trafficking. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Kalirin12
KW - dynamin
KW - guanine nucleotide exchange factors
KW - rats
KW - Rho GTPase
KW - dendrites
KW - 2009
KW - Dendrites
KW - Enzymes
KW - Nucleotides
KW - Proteins
KW - Rats
KW - 2009
U1 - Sponsor: Sponsor name not included. Grant: DA-15464; DA-16871. Recipients: No recipient indicated
DO - 10.1186/1471-2202-10-61
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-10288-001&site=ehost-live&scope=site
UR - eipper@uchc.edu
UR - mains@uchc.edu
UR - chana.rabiner@hhs.gov
UR - xin@nso.uchc.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Zolnik, Banu S.
AU - Sadrieh, Nakissa
T1 - Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2009/06/21/
VL - 61
IS - 6
M3 - Article
SP - 422
EP - 427
SN - 0169409X
AB - Abstract: The promise of nanoscale material containing drug products to treat complex diseases is mounting. According to the literature, in addition to the liposomes, micelles, emulsions, there are novel drug delivery systems such as dendrimers and metal colloids at different stages of pre-clinical and clinical development. With the anticipation that more nanoscale material containing drug products will be submitted to the Food and Drug Administration (FDA) for approval in the future, FDA formed a Nanotechnology Task Force in 2006 to determine the critical regulatory issues regarding nanomaterials. As a result, all centers within the FDA are considering the development of guidance documents to address nanomaterial specific issues. It is well established in the literature that physico-chemical characterization (PCC) studies are crucial for nanomaterial containing drug products. However, this paper addresses the equally important topic of Absorption, Distribution, Metabolism and Excretion (ADME) studies for nanomaterials and provides examples of how physical properties affect biodistribution (i.e. the state of agglomeration, or aggregation, surface characteristics, stability of PEG). This paper also attempts to highlight some of the ADME study design issues related to nanomaterials such as the need for conducting biodistribution studies on each moiety of the multifunctional nanoparticles, dual labeled pharmacokinetic (PK) studies, and comparative PK studies on the free versus encapsulated drugs. In addition, this paper underlines the importance of long-term biodistribution and mass balance studies to understand the nanoparticle accumulation profile which may help to assess the safety and efficacy of the nanomaterial containing drug products. This review also lists some of the pre-clinical guidance documents that may help sponsors get started in developing data for inclusion in an initial investigational new drug application package for nanoscale material containing drug products. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOKINETICS
KW - RESEARCH
KW - DRUGS
KW - NANOCHEMISTRY
KW - Biodistribution
KW - Nanomaterials
KW - Physico-chemical characterization
KW - Regulatory
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 40631219; Zolnik, Banu S. 1 Sadrieh, Nakissa; Email Address: nakissa.sadrieh@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, WO 51, HFD-003 Silver Spring, MD 20993, USA; Source Info: Jun2009, Vol. 61 Issue 6, p422; Subject Term: PHARMACOKINETICS; Subject Term: RESEARCH; Subject Term: DRUGS; Subject Term: NANOCHEMISTRY; Author-Supplied Keyword: Biodistribution; Author-Supplied Keyword: Nanomaterials; Author-Supplied Keyword: Physico-chemical characterization; Author-Supplied Keyword: Regulatory; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.addr.2009.03.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40631219&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hopf, Nancy Brenna
AU - Waters, Martha A.
AU - Ruder, Avima M.
T1 - Cumulative exposure estimates for polychlorinated biphenyls using a job-exposure matrix
JO - Chemosphere
JF - Chemosphere
Y1 - 2009/06/22/
VL - 76
IS - 2
M3 - Article
SP - 185
EP - 193
SN - 00456535
AB - PCB exposure has been associated with increased risk for cancer, neurological disease, and for birth defects in children exposed in utero. Because of the long half-lives of PCB congeners, they remain a public health problem in the United States 30 years after being banned. Workers (n =3569) at an Indiana capacitor manufacturing plant were exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The purpose of this work was to develop a period-specific job-exposure matrix (JEM) for a follow-up epidemiologic study investigating the increased risks for cancer previously observed in the cohort. Methods: We used eight exposure determinants to estimate PCB exposures systematically. Work history, job description, capacitor production factors, PCB usage trends, and air sample data were used to develop the JEM in four steps: (1) all job titles (n =884) were assessed for exposure determinants, (2) jobs with similar exposure determinants were grouped, (3) for each job exposure category, exposure intensity (high¿medium¿low-background) and frequency (continuous¿intermittent) were qualitatively rated separately for inhalation and dermal exposure, and (4) for each job exposure category, the product of intensity (based on air sampling data) and frequency (fraction of day exposed) was calculated. The JEM was then modified for two eras of different PCB exposure conditions. Results: The resulting JEM consists of inhalation and dermal exposure values for 19 job exposure categories. Conclusion: The JEM showed an exposure¿response trend associated with increased brain cancer mortality in the epidemiologic study. [Copyright &y& Elsevier]
AB - Copyright of Chemosphere is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCHLORINATED biphenyls -- Environmental aspects
KW - POLYCHLORINATED biphenyls
KW - RESEARCH
KW - CANCER -- Risk factors -- Research
KW - HUMAN abnormalities
KW - ENVIRONMENTAL toxicology -- Research
KW - EPIDEMIOLOGY -- Research
KW - DATA analysis
KW - RISK factors
KW - Cohort study
KW - Dermal exposures
KW - Exposure assessment
KW - Inhalation exposures
KW - JEM
KW - Job exposure categories
N1 - Accession Number: 40215784; Hopf, Nancy Brenna; Email Address: NancyBHopf@gmail.com Waters, Martha A. 1 Ruder, Avima M. 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, OH, United States; Source Info: Jun2009, Vol. 76 Issue 2, p185; Subject Term: POLYCHLORINATED biphenyls -- Environmental aspects; Subject Term: POLYCHLORINATED biphenyls; Subject Term: RESEARCH; Subject Term: CANCER -- Risk factors -- Research; Subject Term: HUMAN abnormalities; Subject Term: ENVIRONMENTAL toxicology -- Research; Subject Term: EPIDEMIOLOGY -- Research; Subject Term: DATA analysis; Subject Term: RISK factors; Author-Supplied Keyword: Cohort study; Author-Supplied Keyword: Dermal exposures; Author-Supplied Keyword: Exposure assessment; Author-Supplied Keyword: Inhalation exposures; Author-Supplied Keyword: JEM; Author-Supplied Keyword: Job exposure categories; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chemosphere.2009.03.058
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-09761-001
AN - 2009-09761-001
AU - Alagramam, Kumar N.
AU - Brown, Steve D. M.
AU - Davis, Rickie R.
AU - Johnson, Ken R.
AU - Jones, Sherri M.
AU - Macauley, John B.
AU - Zheng, Qing Yin
AU - Zuo, Jian
T1 - Foreword for special issue: Mouse models for hearing research.
T3 - Mouse Models for Hearing Research
JF - Brain Research
JO - Brain Research
JA - Brain Res
Y1 - 2009/06/24/
VL - 1277
SP - 1
EP - 2
CY - Netherlands
PB - Elsevier Science
SN - 0006-8993
SN - 1872-6240
AD - Zuo, Jian
N1 - Accession Number: 2009-09761-001. PMID: 19540992 Partial author list: First Author & Affiliation: Alagramam, Kumar N.; Case Western Reserve University, Cleveland, OH, US. Release Date: 20091109. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Models; Brain; Experimentation. Minor Descriptor: Mice. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20). Page Count: 2. Issue Publication Date: Jun 24, 2009. Copyright Statement: Elsevier B.V. 2009.
AB - This is the second special issue of 'Mouse Models for Hearing Research' published in Brain Research. This issue is comprised solely of topical review articles. All of the reviews focus on the mouse, in keeping with the common theme of the talks, tutorials, posters, and workshops presented at The Mouse as an Instrument for Ear Research III meeting, which took place September 18–21, 2008, at The Jackson Laboratory in Bar Harbor, Maine. The overall objectives of the meeting are to provide non-mouse researchers an introduction to the mouse through tutorials and hands-on workshops, to provide state-of-the-art information to experienced investigators through research talks on new developments and special topics of interest, and to provide new investigators with an opportunity to communicate their research findings through podium and poster presentations. Meeting presenters with expertise in diverse topics were invited to develop review articles describing the current state of research in their respective fields. These manuscripts were peer-reviewed and revised by the authors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - animal models
KW - mice
KW - hearing research
KW - brain research
KW - 2009
KW - Animal Models
KW - Brain
KW - Experimentation
KW - Mice
KW - 2009
DO - 10.1016/j.brainres.2009.05.048
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-09761-001&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9264-2021
UR -
UR - jian.zuo@stjude.org
DP - EBSCOhost
DB - psyh
ER -
TY - NEWS
AU - Dhruva, Sanket S.
AU - Phurrough, Steve E.
AU - Salive, Marcel E.
AU - Redberg, Rita F.
T1 - CMS's Landmark Decision on CT Colonography — Examining the Relevant Data.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/06/25/
VL - 360
IS - 26
M3 - Editorial
SP - 2699
EP - 2701
SN - 00284793
AB - The authors comment on the decision of the U.S. Centers for Medicare and Medicaid Services (CMS) to deny coverage of computed tomographic (CT) colonography for screening cancer. They hope that the strict application of evidence-based analysis would lead to a shift in its approach to national coverage decisions. They add that their optimism is cautious, the pressure of which will be inevitably on the CMS. They also mention that colorectal cancer screening is a procedure for which the CMS is particularly authorized to consider costs.
KW - TOMOGRAPHY
KW - EVIDENCE-based medicine
KW - COLON cancer -- Diagnosis
KW - UNITED States
KW - CENTERS for Medicare & Medicaid Services (U.S.)
N1 - Accession Number: 42420443; Dhruva, Sanket S. 1 Phurrough, Steve E. 2 Salive, Marcel E. 3 Redberg, Rita F. 4; Affiliation: 1: resident, University of California, San Francisco, School of Medicine, San Francisco 2: medical officer, Agency for Healthcare Research and Quality, Rockville, MD 3: director, Division of Medical and Surgical Services, CMS, Baltimore 4: professor of medicine, University of California, San Francisco, School of Medicine, San Francisco; Source Info: 6/25/2009, Vol. 360 Issue 26, p2699; Subject Term: TOMOGRAPHY; Subject Term: EVIDENCE-based medicine; Subject Term: COLON cancer -- Diagnosis; Subject Term: UNITED States; Company/Entity: CENTERS for Medicare & Medicaid Services (U.S.); NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1413
L3 - 10.1056/NEJMp0904408
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fink Jr., Donald W.
T1 - FDA Regulation of Stem Cell-Based Products.
JO - Science
JF - Science
Y1 - 2009/06/26/
VL - 324
IS - 5935
M3 - Article
SP - 1662
EP - 1663
SN - 00368075
AB - Cell self-renewal and the capacity to differentiate into multiple cell types (pluripotency) are biological attributes casting stem cells as attractive candidates for development of therapies targeting indications that involve functional restoration of damaged tissues. In the United States, clinical trials designed to demonstrate the safety and effectiveness of stem cell-based products are regulated by the U.S. Food and Drug Administration (FDA). To ensure that subjects enrolled in a clinical study involving stem cell-based products are not exposed to significant and unreasonable risk, the FDA reviews medical and scientific information that encompasses delineation of product-specific characteristics and preclinical testing to determine whether there is sufficient safety assurance to permit initiation of human clinical studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL proliferation
KW - RESEARCH
KW - STEM cell research -- Law & legislation
KW - CLINICAL trials
KW - MEDICAL sciences
KW - CYTOLOGY -- Research
KW - GOVERNMENT policy
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 43083966; Fink Jr., Donald W. 1; Email Address: donald.fink@fda.hhs.gov; Affiliation: 1: Cell Therapy Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Suite 20ON, Mail Code HFM-720, Rockville, MD 20852-1448, USA; Source Info: 6/26/2009, Vol. 324 Issue 5935, p1662; Subject Term: CELL proliferation; Subject Term: RESEARCH; Subject Term: STEM cell research -- Law & legislation; Subject Term: CLINICAL trials; Subject Term: MEDICAL sciences; Subject Term: CYTOLOGY -- Research; Subject Term: GOVERNMENT policy; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Sedrakyan, Art
T1 - CABG versus PCI for multivessel coronary artery disease.
JO - Lancet
JF - Lancet
Y1 - 2009/06/27/
VL - 373
IS - 9682
M3 - Letter
SP - 2199
EP - 2200
SN - 00995355
AB - A letter to the editor is presented in response to a study which compared coronary artery bypass grafting (CABG) and percutaneous coronary interventions for multivessel disease, by Mark Hlatky and colleagues in the April 4, 2009 issue.
KW - LETTERS to the editor
KW - CORONARY artery bypass
KW - CORONARY heart disease
N1 - Accession Number: 42638601; Sedrakyan, Art 1; Email Address: Art.Sedrakyan@fda.hhs.gov; Affiliation: 1: Agency For Healthcare Research and Quality, Department of Health and Human Services, Center for Outcomes and Evidence, Rockville, MD 20850, USA; Source Info: 6/27/2009, Vol. 373 Issue 9682, p2199; Subject Term: LETTERS to the editor; Subject Term: CORONARY artery bypass; Subject Term: CORONARY heart disease; Number of Pages: 2p; Illustrations: 1 Color Photograph; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105386931
T1 - Identifying and using good practice guidelines.
AU - Lin K
AU - Slawson DC
Y1 - 2009/07//7/1/2009
N1 - Accession Number: 105386931. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 1272646.
KW - Medical Practice, Evidence-Based -- Methods
KW - Practice Guidelines -- Standards
KW - Quality Assurance -- Methods
KW - United States
SP - 67
EP - 69
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 80
IS - 1
CY - Skokie, Illinois
PB - American Academy of Family Physicians
AB - Performance measurement and payment are increasingly linked to goals established by practice guidelines. The best guidelines are based on systematic reviews and patient-oriented evidence, use an evidence-rating system such as the Strength of Recommendation Taxonomy, and are prospectively validated. The guidelines also should have a transparent development process, identify potential conflicts of interest, and offer flexibility in various clinical situations.
SN - 0002-838X
AD - Agency for Healthcare Research and Quality, Rockville, MA, USA.
U2 - PMID: 19621847.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105386931&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105375920
T1 - Reengineering hospital discharge: a protocol to improve patient safety, reduce costs, and boost patient satisfaction.
AU - Clancy CM
Y1 - 2009/07//Jul/Aug2009
N1 - Accession Number: 105375920. Language: English. Entry Date: 20091002. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Health Services Administration; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9300756.
KW - Patient Discharge
KW - Protocols
KW - Safety
KW - Patient Centered Care -- Administration
KW - Patient Satisfaction
KW - Readmission
KW - Safety -- Economics
SP - 344
EP - 346
JO - American Journal of Medical Quality
JF - American Journal of Medical Quality
JA - AM J MED QUAL
VL - 24
IS - 4
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1062-8606
AD - Agency for Healthcare Research and Quality, Rockville, Maryland.
U2 - PMID: 19502567.
DO - 10.1177/1062860609338131
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105375920&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Klabunde, Carrie N.
AU - Lanier, David
AU - Nadel, Marion R.
AU - McLeod, Caroline
AU - Yuan, Gigi
AU - Vernon, Sally W.
T1 - Colorectal Cancer Screening by Primary Care Physicians: Recommendations and Practices, 2006–2007
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
Y1 - 2009/07//
VL - 37
IS - 1
M3 - Article
SP - 8
EP - 16
SN - 07493797
AB - Background: Primary care physicians (hereafter, physicians) play a critical role in the delivery of colorectal cancer (CRC) screening in the U.S. This study describes the CRC screening recommendations and practices of U.S. physicians and compares them to findings from a 1999–2000 national provider survey. Methods: Data from 1266 physicians responding to the 2006–2007 National Survey of Primary Care Physicians'' Recommendations and Practices for Breast, Cervical, Colorectal, and Lung Cancer Screening (cooperation rate=75%) were analyzed in 2008. Descriptive statistics were used to examine physicians'' CRC screening recommendations and practices as well as the office systems used to support screening activities. Sample weights were applied in the analyses to obtain national estimates. Results: Ninety-five percent of physicians routinely recommend screening colonoscopy to asymptomatic, average-risk patients; 80% recommend fecal occult blood testing (FOBT). Only a minority recommend sigmoidoscopy, double-contrast barium enema, computed tomographic colonography, or fecal DNA testing. Fifty-six percent recommend two screening modalities; 17% recommend one. Nearly all physicians who recommend endoscopy refer their patients for the procedure. Four percent perform sigmoidoscopy, a 25-percentage-point decline from 1999–2000. Although 61% of physicians reported that their practice had guidelines for CRC screening, only 30% use provider reminders; 15% use patient reminders. Conclusions: Physicians'' CRC screening recommendations and practices have changed substantially since 1999–2000. Colonoscopy is now the most frequently recommended test. Most physicians do not recommend the full menu of test options prescribed in national guidelines. Few perform sigmoidoscopy. Office systems to support CRC screening are lacking in many physicians'' practices. Given ongoing changes in CRC screening technologies and guidelines, the continued monitoring of physicians'' CRC screening recommendations and practices is imperative. [Copyright &y& Elsevier]
AB - Copyright of American Journal of Preventive Medicine is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHYSICIANS
KW - MEDICINE -- Practice
KW - COLONOSCOPY
KW - COLON cancer
N1 - Accession Number: 41584438; Klabunde, Carrie N. 1; Email Address: klabundc@mail.nih.gov Lanier, David 2 Nadel, Marion R. 3 McLeod, Caroline 4 Yuan, Gigi 5 Vernon, Sally W. 6; Affiliation: 1: Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda 2: Center for Primary Care, Prevention, and Clinical Partnerships, the Agency for Healthcare Research and Quality, Rockville 3: Division of Cancer Prevention and Control, CDC, Atlanta, Georgia 4: Westat, Rockville 5: Information Management Services, Inc., Silver Spring, Maryland 6: Division of Health Promotion and Behavioral Sciences, University of Texas–Houston School of Public Health, Houston, Texas; Source Info: Jul2009, Vol. 37 Issue 1, p8; Subject Term: PHYSICIANS; Subject Term: MEDICINE -- Practice; Subject Term: COLONOSCOPY; Subject Term: COLON cancer; NAICS/Industry Codes: 621111 Offices of Physicians (except Mental Health Specialists); NAICS/Industry Codes: 621110 Offices of physicians; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.amepre.2009.03.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41584438&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105373584
T1 - Evaluation of COSHH essentials: methylene chloride, isopropanol, and acetone exposures in a small printing plant.
AU - Lee EG
AU - Harper M
AU - Bowen RB
AU - Slaven J
Y1 - 2009/07//
N1 - Accession Number: 105373584. Language: English. Entry Date: 20091016. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Air Pollutants, Occupational -- Analysis
KW - Graphics
KW - Hazardous Materials -- Analysis
KW - Models, Theoretical
KW - Occupational Exposure -- Prevention and Control
KW - Propanols -- Analysis
KW - Environmental Monitoring -- Methods
KW - Hydrocarbons, Chlorinated -- Analysis
KW - Ketones -- Analysis
KW - Risk Assessment -- Methods
KW - Human
SP - 463
EP - 474
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 5
PB - Oxford University Press / USA
SN - 0003-4878
AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
U2 - PMID: 19435980.
DO - annhyg/mep023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105373584&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Young-Beom Ahn
AU - Jong-Chan Chae
AU - Zylstra, Gerben J.
AU - Häggblom, Max M.
T1 - Degradation of Phenol via Phenyiphosphate and Carboxylation to 4-Hydroxybenzoate by a Newly Isolated Strain of the Sulfate-Reducing Bacterium Desulfobacterium anilini.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/07//
VL - 75
IS - 13
M3 - Article
SP - 4248
EP - 4253
SN - 00992240
AB - A sulfate-reducing phenol-degrading bacterium, strain AK1, was isolated from a 2-bromophenol-utilizing sulfidogenic estuarine sediment enrichment culture. On the basis of phylogenetic analysis of the 16S rRNA gene and DNA homology, strain AK1 is most closely related to Desulfobacterium anilini strain Anil ( DSM 4660T). In addition to phenol, this organism degrades a variety of other aromatic compounds, including benzoate, 2-hydroxybenzoate, 4-hydroxybenzoate, 4-hydroxyphenylacetate, 2-aminobenzoate, 2-fluorophenol, and 2-fiuorobenzoate, but it does not degrade aniline, 3.hydroxybenzoate, 4.cyanophenol, 2,4.dihydroxybenzoate, monohalogenated phenols, or monohalogenated benzoates. Growth with sulfate as an electron acceptor occurred with acetate and pyruvate but not with citrate, propionate, butyrate, lactate, glucose, or succinate. Strain AK1 is able to use sulfate, sulfite, and thiosulfate as electron acceptors. A putative phenylphosphate synthase gene responsible for anaerobic phenol degradation was identified in strain AK1. In phenol-grown cultures inducible expression of the ppsA gene was verified by reverse transcriptase PCR, and 4-hydroxyben- zoate was detected as an intermediate. These results suggest that the pathway for anaerobic degradation of phenol in D. anilini strain AK1 proceeds via phosphorylation of phenol to phenylphosphate, followed by carboxylation to 4-hydroxybenzoate. The details concerning such reaction pathways in sulfidogenic bacteria have not been characterized previously. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOL
KW - PHENOLS
KW - AROMATIC compounds
KW - ESTUARINE sediments
KW - POLLUTANTS
KW - BACTERIA
KW - BIODEGRADATION
KW - PHOSPHORYLATION
KW - CHEMICAL reactions
N1 - Accession Number: 43314209; Young-Beom Ahn 1,2,3 Jong-Chan Chae 2,4 Zylstra, Gerben J. 1,2 Häggblom, Max M. 1,2; Email Address: haggblom@aesop.rutgers.edu; Affiliation: 1: Department of Biochemistty and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901 2: Department of Biotechnology Center for Agriculture and the Environment, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901 3: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502 4: Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 570-752, South Korea; Source Info: Jul2009, Vol. 75 Issue 13, p4248; Subject Term: PHENOL; Subject Term: PHENOLS; Subject Term: AROMATIC compounds; Subject Term: ESTUARINE sediments; Subject Term: POLLUTANTS; Subject Term: BACTERIA; Subject Term: BIODEGRADATION; Subject Term: PHOSPHORYLATION; Subject Term: CHEMICAL reactions; NAICS/Industry Codes: 325110 Petrochemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; Number of Pages: 6p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.00203-09
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105502610
T1 - Effects of foot placement on postural stability of construction workers on stilts.
AU - Pan CS
AU - Chiou S
AU - Kau TY
AU - Bhattacharya A
AU - Ammons D
Y1 - 2009/07//
N1 - Accession Number: 105502610. Language: English. Entry Date: 20090717. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0261412.
KW - Balance, Postural -- Physiology
KW - Foot -- Physiology
KW - Occupational Health
KW - Accidental Falls -- Prevention and Control
KW - Adult
KW - Analysis of Variance
KW - Assistive Technology Devices
KW - Construction Materials
KW - Male
KW - Human
SP - 781
EP - 789
JO - Applied Ergonomics
JF - Applied Ergonomics
JA - APPL ERGON
VL - 40
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0003-6870
AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-G800, Morgantown, WV 26505, USA. cpan@cdc.gov
U2 - PMID: 18952203.
DO - 10.1016/j.apergo.2008.08.003
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vo, Evanly
AU - Zhuang, Zhenzhen
T1 - The Use of Aldehyde Indicators to Determine Glutaraldehyde and Alkaline Glutaraldehyde Contamination in Chemical Protective Gloves.
JO - Archives of Environmental Contamination & Toxicology
JF - Archives of Environmental Contamination & Toxicology
Y1 - 2009/07//
VL - 57
IS - 1
M3 - Article
SP - 185
EP - 192
PB - Springer Science & Business Media B.V.
SN - 00904341
AB - The aim of this study was to assess the use of aldehyde indicator pads for detection of glutaraldehyde and alkaline glutaraldehyde permeation through chemical protective gloves under simulated in-use conditions. The quantitative analysis of glutaraldehyde permeation through a glove material was determined for Metricide, Wavicide, and 50% glutaraldehyde following a solvent-desorption process and gas chromatographic analysis. All glutaraldehyde solutions exhibited >99% adsorption (including both the glutaraldehyde oligomers of the reaction product and the excess glutaraldehyde) on the pads over the spiking range 0.05–5.0 μL. Breakthrough times for protective gloves were determined using the Thermo-Hand test method, and found to range from 76 to 150, from 170 to 230, and from 232 to 300 min for Metricide, Wavicide, and 50% glutaraldehyde, respectively. Glutaraldehyde recovery was calculated and ranged from 61 to 80% for all glutaraldehyde solutions. The mass of glutaraldehyde in these solutions at the time of breakthrough detection ranged from 17 to 18, from 18 to 19, and from 19 to 20 μg/cm2 for Wavicide, 50% glutaraldehyde solution, and Metricide, respectively. Aldehyde indicator pads and the Thermo-Hand test method together should find utility in detecting, collecting, and quantitatively analyzing glutaraldehyde permeation samples through chemical protective gloves under simulated in-use conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Gas chromatography
KW - Gloves
KW - Indicators & test-papers
KW - Aldehydes -- Reactivity
KW - Commercial products -- Testing
N1 - Accession Number: 40076787; Vo, Evanly 1; Email Address: Eav8@cdc.gov; Zhuang, Zhenzhen 1; Affiliations: 1: CDC, National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road Pittsburgh 15236 USA; Issue Info: Jul2009, Vol. 57 Issue 1, p185; Thesaurus Term: Industrial safety; Thesaurus Term: Gas chromatography; Subject Term: Gloves; Subject Term: Indicators & test-papers; Subject Term: Aldehydes -- Reactivity; Subject Term: Commercial products -- Testing; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 315990 Apparel Accessories and Other Apparel Manufacturing; NAICS/Industry Codes: 414110 Clothing and clothing accessories merchant wholesalers; NAICS/Industry Codes: 315190 Other Apparel Knitting Mills; NAICS/Industry Codes: 315210 Cut and Sew Apparel Contractors; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1007/s00244-009-9316-9
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Strauss, Daniel M.
AU - Lute, Scott
AU - Brorson, Kurt
AU - Blank, Gregory S.
AU - Chen, Qi
AU - Yang, Bin
T1 - Removal of endogenous retrovirus-like particles from CHO-cell derived products using Q sepharose fast flow chromatography.
JO - Biotechnology Progress
JF - Biotechnology Progress
Y1 - 2009/07//
VL - 25
IS - 4
M3 - Article
SP - 1194
EP - 1197
SN - 87567938
AB - Retrovirus-like particles (RVLPs) that are expressed during the production of monoclonal antibodies in Chinese hamster ovary (CHO) cell cultures must be removed during product recovery. Anion exchange chromatography (AEX) performed in product flow-through mode, a common component in the purification of monoclonal antibodies, has been shown to provide robust removal of a related retrovirus model, but it's ability to remove the actual RVLP impurities has not been directly investigated. We have determined the ability of a typical Q sepharose process to remove actual CHO RVLP impurities. Using small scale experiments with three model antibodies, we observe that this AEX process is capable of effectively removing both in-process and spiked RVLPs from different feedstocks containing different mAb products. In addition, we show that this AEX process also achieves a similarly high degree of RVLP removal during large scale manufacturing operations. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Biotechnology Progress is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Hamsters
KW - Retroviruses
KW - Monoclonal antibodies
KW - Immunoglobulins
KW - Cell culture
KW - Manufacturing processes
N1 - Accession Number: 64272913; Strauss, Daniel M. 1; Lute, Scott 2; Brorson, Kurt 2; Blank, Gregory S. 1; Chen, Qi 1; Yang, Bin 1; Affiliations: 1: Process Research and Development, Late Stage Purification, Genentech Inc., One DNA Way, South San Francisco, CA 94080; 2: Div. of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903; Issue Info: Jul2009, Vol. 25 Issue 4, p1194; Thesaurus Term: Hamsters; Subject Term: Retroviruses; Subject Term: Monoclonal antibodies; Subject Term: Immunoglobulins; Subject Term: Cell culture; Subject Term: Manufacturing processes; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; Number of Pages: 4p; Document Type: Article
L3 - 10.1002/btpr.249
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Gubernot, Diane M.
AU - Wise, Robert P.
AU - Spinola, Stanley M.
T1 - Fatality Despite Appropriate Treatment for Babesiosis.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/07//7/1/2009
VL - 49
IS - 1
M3 - Letter
SP - 166
EP - 167
SN - 10584838
AB - A letter to the editor is presented in response to the article about a patient who received a therapy for presumptive severe plasmodium falciparum malaria in the previous issue.
KW - Letters to the editor
KW - Plasmodium falciparum -- Therapeutic use
N1 - Accession Number: 41891690; Gubernot, Diane M. 1; Email Address: diane.gubernot@fda.hhs.gov; Wise, Robert P. 1; Spinola, Stanley M. 2; Affiliations: 1: Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland; 2: Department of Medicine, Indiana University, Indianapolis; Issue Info: 7/1/2009, Vol. 49 Issue 1, p166; Subject Term: Letters to the editor; Subject Term: Plasmodium falciparum -- Therapeutic use; Number of Pages: 2p; Document Type: Letter
L3 - 10.1086/599621
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DP - EBSCOhost
DB - eih
ER -
TY -
AU - Soon, Guoxing (Greg)1, guoxing.soon@fda.hhs.gov
T1 - Minimizing Missing Data in Clinical Trials: Design, Operation, and Regulatory Considerations.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2009/07//
Y1 - 2009/07//
VL - 43
IS - 4
CP - 4
M3 - Article
SP - 485
EP - 492
SN - 00928615
AB - The ultimate question to be answered in a clinical trial is "What benefit/risk has the drug caused to the patient?" To answer this question, it is critical to avoid missing data on outcome that measures benefit and risk from the beginning. This article emphasizes that when a patient discontinues the study treatment, instead of trying to impute the missing outcome values, effort should be made to follow the patient until the endpoint or the end of the trial. The information in the follow-up period can be used to describe the benefit/risk to those patients who would discontinue treatment in the actual clinical practice, while imputing values that are not observed, yet may never exist, can only answer the unrealistic question, "What would have happened had the subject not discontinued?" Minimizing missing data is possible through the joint efforts of drug companies and regulatory agencies. Drug companies can improve their efforts in study design and operation, including off treatment follow-up, prioritization of information collection, endpoint selection, and detailed documentation of reasons for missing data. Regulatory agencies can provide general guidance and convey specific comments for improvement through protocol review regarding missing data, and can ensure proper labeling language that reflects the extent of missing data and the reliability of conclusions. [ABSTRACT FROM AUTHOR]
KW - Clinical trials
KW - Patients
KW - Pharmaceutical industry
KW - Therapeutics
KW - Missing data (Statistics)
KW - Drugs -- Marketing
KW - Benefit/risk, Minimizing missing data
KW - Clinical trial
KW - Labeling
KW - MAR
KW - MCAR
KW - Off-treatment follow-up
KW - Sensitivity analysis
KW - Statistical methods
N1 - Accession Number: 43347609; Authors: Soon, Guoxing (Greg) 1 Email Address: guoxing.soon@fda.hhs.gov; Affiliations: 1: Lead Mathematical Statistician, Division of Biometrics IV, Office of Biostatistics, Office of Translational Science, Center for Drug Evaluation and Research, Food and Drag Administration, Silver Spring, Maryland; Subject: Clinical trials; Subject: Patients; Subject: Pharmaceutical industry; Subject: Therapeutics; Subject: Missing data (Statistics); Subject: Drugs -- Marketing; Author-Supplied Keyword: Benefit/risk, Minimizing missing data; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Labeling; Author-Supplied Keyword: MAR; Author-Supplied Keyword: MCAR; Author-Supplied Keyword: Off-treatment follow-up; Author-Supplied Keyword: Sensitivity analysis; Author-Supplied Keyword: Statistical methods; Number of Pages: 8p; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - Yamada, Hirotomo
AU - Uenishi, Rie
AU - Suzuki, Kaoru
AU - Koizumi, Shinji
T1 - Cadmium-induced alterations of gene expression in human cells
JO - Environmental Toxicology & Pharmacology
JF - Environmental Toxicology & Pharmacology
Y1 - 2009/07//
VL - 28
IS - 1
M3 - Article
SP - 61
EP - 69
SN - 13826689
AB - We have reported the changes in gene expression in human HeLa cells exposed to a low concentration (5μM) of Cd. In the present study, cells exposed to a higher concentration of Cd were analyzed using a DNA microarray with 9182 human cDNA probes, in an attempt to obtain a comprehensive view on the biological effects of Cd. After a 6h exposure to 50μM Cd, 48 genes were up-regulated 2.5-fold or greater and 14 genes were down-regulated to 40% or less. Marked up-regulation of genes coding for metallothioneins, anti-oxidant proteins, and heat shock proteins was observed. Cd appeared to repress cell proliferation by modulating genes involved in multiple pathways. Cd also affected a number of genes related to apoptosis. Interestingly, it appeared that a series of genes were regulated to accelerate the intrinsic pathway of apoptosis, while others were directed to suppress the extrinsic pathway. Of these, rapid and transient induction of the TR3 gene was noted as a possible key process in Cd-induced apoptosis. Effects on several genes that may reflect mechanistic backgrounds of Cd toxicity were also observed. The present study disclosed a complex pleiotypic response of human cells to Cd, which was composed of a variety of changes in gene expression directed to defense, growth arrest, recovery from damage, apoptosis and so on. [Copyright &y& Elsevier]
AB - Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM -- Physiological effect
KW - CADMIUM poisoning
KW - GENE expression
KW - RESEARCH
KW - CYTOLOGY -- Research
KW - HELA cells
KW - DNA microarrays
KW - METALLOTHIONEIN
KW - ANTIOXIDANTS
KW - Apoptosis
KW - Cadmium
KW - DNA microarray
KW - Growth arrest
KW - HeLa cells
N1 - Accession Number: 39782450; Yamada, Hirotomo 1 Uenishi, Rie Suzuki, Kaoru 1 Koizumi, Shinji; Email Address: koizumi@h.jniosh.go.jp; Affiliation: 1: Human Engineering and Risk Management Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Source Info: Jul2009, Vol. 28 Issue 1, p61; Subject Term: CADMIUM -- Physiological effect; Subject Term: CADMIUM poisoning; Subject Term: GENE expression; Subject Term: RESEARCH; Subject Term: CYTOLOGY -- Research; Subject Term: HELA cells; Subject Term: DNA microarrays; Subject Term: METALLOTHIONEIN; Subject Term: ANTIOXIDANTS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: DNA microarray; Author-Supplied Keyword: Growth arrest; Author-Supplied Keyword: HeLa cells; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.etap.2009.02.007
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Paule, Merle G.
T1 - S08: Ketamine-induced neurodevelopmental toxicity
JO - Experimental & Toxicologic Pathology
JF - Experimental & Toxicologic Pathology
Y1 - 2009/07//
VL - 61
IS - 4
M3 - Abstract
SP - 392
EP - 393
SN - 09402993
N1 - Accession Number: 40633491; Paule, Merle G. 1; Affiliations: 1: FDA (Division of Neurotoxicology), National Center for Toxicological Research, USA; Issue Info: Jul2009, Vol. 61 Issue 4, p392; Number of Pages: 2p; Document Type: Abstract
L3 - 10.1016/j.etp.2009.02.077
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DP - EBSCOhost
DB - eih
ER -
TY - ABST
AU - Paule, Merle G.
T1 - S10: Primate models of neurotoxicity
JO - Experimental & Toxicologic Pathology
JF - Experimental & Toxicologic Pathology
Y1 - 2009/07//
VL - 61
IS - 4
M3 - Abstract
SP - 394
EP - 394
SN - 09402993
N1 - Accession Number: 40633493; Paule, Merle G. 1; Affiliations: 1: FDA (Division of Neurotoxicology), National Center for Toxicological Research, USA; Issue Info: Jul2009, Vol. 61 Issue 4, p394; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.etp.2009.02.079
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Song, Ming-Fen
AU - Li, Yun-Shan
AU - Ootsuyama, Yuko
AU - Kasai, Hiroshi
AU - Kawai, Kazuaki
AU - Ohta, Masanori
AU - Eguchi, Yasumasa
AU - Yamato, Hiroshi
AU - Matsumoto, Yuki
AU - Yoshida, Rie
AU - Ogawa, Yasutaka
T1 - Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
Y1 - 2009/07//
VL - 47
IS - 1
M3 - Article
SP - 41
EP - 46
SN - 08915849
AB - Abstract: Urinary 8-OH-dG is commonly analyzed as a marker of oxidative stress. For its analysis, ELISA and HPLC methods are generally used, although discrepancies in the data obtained by these methods have often been discussed. To clarify this problem, we fractionated human urine by reverse-phase HPLC and assayed each fraction by the ELISA method. In addition to the 8-OH-dG fraction, a positive reaction was observed in the first eluted fraction. The components in this fraction were examined by the ELISA. Urea was found to be the responsible component in this fraction. Urea is present in high concentrations in the urine of mice, rats, and humans, and its level is influenced by many factors. Therefore, certain improvements, such as a correction based on urea content or urease treatment, are required for the accurate analysis of urinary 8-OH-dG by the ELISA method. In addition, performance of the ELISA at 4°C reduced the recognition of urea considerably and improved the 8-OH-dG analysis. [Copyright &y& Elsevier]
AB - Copyright of Free Radical Biology & Medicine is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - UREA
KW - URINALYSIS
KW - BIOCHEMICAL markers
KW - ENZYME-linked immunosorbent assay
KW - OXIDATIVE stress
KW - HIGH performance liquid chromatography
KW - FREE radicals (Chemistry)
KW - 8-OH-dG
KW - Biomarker
KW - ELISA
KW - Free radicals
KW - Oxidative stress
N1 - Accession Number: 40633887; Song, Ming-Fen 1 Li, Yun-Shan 1 Ootsuyama, Yuko 1 Kasai, Hiroshi 1 Kawai, Kazuaki 1; Email Address: kkawai@med.uoeh-u.ac.jp Ohta, Masanori 2 Eguchi, Yasumasa 2 Yamato, Hiroshi 2 Matsumoto, Yuki 3,4 Yoshida, Rie 3 Ogawa, Yasutaka 3,4; Affiliation: 1: Department of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan 2: Department of Health Development, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan 3: National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan 4: Graduate School of Medical Science, Kitasato University, Sagamihara 228-8555, Japan; Source Info: Jul2009, Vol. 47 Issue 1, p41; Subject Term: UREA; Subject Term: URINALYSIS; Subject Term: BIOCHEMICAL markers; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: OXIDATIVE stress; Subject Term: HIGH performance liquid chromatography; Subject Term: FREE radicals (Chemistry); Author-Supplied Keyword: 8-OH-dG; Author-Supplied Keyword: Biomarker; Author-Supplied Keyword: ELISA; Author-Supplied Keyword: Free radicals; Author-Supplied Keyword: Oxidative stress; NAICS/Industry Codes: 325313 Chemical fertilizer (except potash) manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.freeradbiomed.2009.02.017
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Akaleephan, Chutima
AU - Wibulpolprasert, Suwit
AU - Sakulbumrungsil, Rungpetch
AU - Luangruangrong, Paithip
AU - Jitraknathee, Anchalee
AU - Aeksaengsri, Achara
AU - Udomaksorn, Siripa
AU - Tangcharoensathien, Viroj
AU - Tantivess, Sripen
T1 - Extension of market exclusivity and its impact on the accessibility to essential medicines, and drug expense in Thailand: Analysis of the effect of TRIPs-Plus proposal
JO - Health Policy
JF - Health Policy
Y1 - 2009/07//
VL - 91
IS - 2
M3 - Article
SP - 174
EP - 182
SN - 01688510
AB - Abstract: Background: In Thailand and the US negotiating FTA, the ‘TRIPs-Plus’ is one of the US proposal which would result in an extension of market exclusivity of innovative drugs. In addition, it would foreseeably lead to high and unaffordable medicine prices and inaccessibility to essential medicines. Objective: To quantify the impact on medicine expense and medicine accessibility. Methods: Based on 2000 to 2003 Thai Food and Drug Administration (FDA)’s and the Drug & Medical Supply Information Center (DMSIC), costs and accessibility were estimated upon the price and quantity costing between innovative drugs and their generics plus some parameters found from their competitive behaviour. Thereafter, we simulated the 10-year potential additional expense on the 2003 unit price of the patented and monopolized non-patented medicines. Results: In 2003, the availability of generics helped to save 104.5% of actual expense and the accessibility would increase by 53.6%. By extension of market exclusivity, given that there were 60 new items approved annually, the cumulative potential expense was projected to be $US 6.2 million for the first year to $US 5215.8 million in tenth year. Conclusion: The TRIPs-Plus proposal would result in a significant increase in the medicine expense; and a delay in the increase in drug accessibility via generics. Several options as well as other related mechanisms to help reduce the negative impact are proposed. [Copyright &y& Elsevier]
AB - Copyright of Health Policy is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUG traffic
KW - PATENT laws & legislation
KW - GENERIC drugs
KW - THAILAND
KW - Cost saving
KW - Generic drugs
KW - Intellectual property
KW - Market exclusivity
KW - Patents as topic
KW - Policy
KW - TRIPs-Plus
N1 - Accession Number: 41582329; Akaleephan, Chutima 1; Email Address: chutima@ihpp.thaigov.net; Wibulpolprasert, Suwit 2; Sakulbumrungsil, Rungpetch 3; Luangruangrong, Paithip 4; Jitraknathee, Anchalee 5; Aeksaengsri, Achara 6; Udomaksorn, Siripa 7; Tangcharoensathien, Viroj 1; Tantivess, Sripen 1; Affiliations: 1: International Health Policy Program-Thailand, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi 11000, Thailand; 2: Ministry of Public Health, Thailand; 3: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand; 4: Drug and Medical Supply Information Center, Ministry of Public Health, Thailand; 5: Drug Control Division, Food and Drug Administration, Ministry of Public Health, Thailand; 6: Research and Development Institute, Government Pharmaceutical Organization, Thailand; 7: Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand; Issue Info: Jul2009, Vol. 91 Issue 2, p174; Thesaurus Term: DRUG traffic; Thesaurus Term: PATENT laws & legislation; Subject Term: GENERIC drugs; Subject: THAILAND; Author-Supplied Keyword: Cost saving; Author-Supplied Keyword: Generic drugs; Author-Supplied Keyword: Intellectual property; Author-Supplied Keyword: Market exclusivity; Author-Supplied Keyword: Patents as topic; Author-Supplied Keyword: Policy; Author-Supplied Keyword: TRIPs-Plus; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.healthpol.2008.12.009
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Holmér, Ingvar
AU - Parsons, Ken C.
AU - Tochihara, Yutaka
AU - Sawada, Shin-Ichi
T1 - Editorial: Cold Stress at Work: Preventive Research.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/07//
VL - 47
IS - 3
M3 - Article
SP - 205
EP - 206
SN - 00198366
AB - The article discusses various reports published within the issue, including one by Ingvar Holmér on cold exposure, one by Kalev Kuklane on performance of feet and hands, and one by Hein A.M. Daanen on wind chill temperature.
KW - Cold (Temperature)
KW - Wind chill index
N1 - Accession Number: 43086774; Holmér, Ingvar 1; Parsons, Ken C. 2; Tochihara, Yutaka 3; Sawada, Shin-Ichi 4; Affiliations: 1: Ergonomics Department, Faculty of Engineering, Lund University, Sweden; 2: Department of Human Sciences, Loughborough University, UK; 3: Department of Design Sciences, Kyushu University, Japan; 4: National Institute of Occupational Safety and Health (JNIOSH), Japan; Issue Info: 2009, Vol. 47 Issue 3, p205; Thesaurus Term: Cold (Temperature); Subject Term: Wind chill index; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Foley, Steven L.
AU - Lynne, Aaron M.
AU - Nayak, Rajesh
T1 - Molecular typing methodologies for microbial source tracking and epidemiological investigations of Gram-negative bacterial foodborne pathogens
JO - Infection, Genetics & Evolution
JF - Infection, Genetics & Evolution
Y1 - 2009/07//
VL - 9
IS - 4
M3 - Article
SP - 430
EP - 440
SN - 15671348
AB - Abstract: Gram-negative bacterial foodborne pathogens are a worldwide cause of morbidity and mortality. The ability to carry out epidemiological investigations to determine the primary sources of bacterial contamination is important to improve public health. Multiple methods are available for bacterial source tracking and to determine the distribution of pathogens isolated from sick patients. The molecular based typing methods available fall into three general categories: those based on restriction analysis of the bacterial DNA; those based on polymerase chain reaction (PCR) amplification of particular genetic targets; and those based on the identification of DNA sequence polymorphisms. The techniques that are examined in this review include: plasmid analysis, restriction fragment length polymorphism methods, pulsed-field gel electrophoresis, amplified fragment length polymorphism analysis, PCR-based genotyping, variable number of tandem repeat analysis, multilocus sequence typing, and single nucleotide polymorphism analysis. These methods are described along with a discussion of the strengths and weaknesses of the techniques for genotyping the major Gram-negative foodborne pathogens—Campylobacter spp., Salmonella enterica, Shigella spp., Escherichia coli, and Yersinia enterocolitica. [Copyright &y& Elsevier]
AB - Copyright of Infection, Genetics & Evolution is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOLECULAR microbiology
KW - GRAM-negative bacterial diseases
KW - FOOD pathogens
KW - SCIENTIFIC method
KW - EPIDEMIOLOGY
KW - PUBLIC health
KW - POLYMERASE chain reaction
KW - DEATH -- Causes
KW - DISEASES -- Causes & theories of causation
KW - Amplification-based typing methods
KW - Gram-negative bacterial typing methods
KW - Restriction-based typing
KW - Sequencing-based typing
N1 - Accession Number: 40115731; Foley, Steven L. 1; Email Address: foleysteven@yahoo.com Lynne, Aaron M. 2 Nayak, Rajesh 3; Affiliation: 1: National Farm Medicine Center, Marshfield Clinic Research Foundation, Marshfield, WI 54449, United States 2: Department of Biological Sciences, Sam Houston State University, Huntsville, TX, United States 3: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States; Source Info: Jul2009, Vol. 9 Issue 4, p430; Subject Term: MOLECULAR microbiology; Subject Term: GRAM-negative bacterial diseases; Subject Term: FOOD pathogens; Subject Term: SCIENTIFIC method; Subject Term: EPIDEMIOLOGY; Subject Term: PUBLIC health; Subject Term: POLYMERASE chain reaction; Subject Term: DEATH -- Causes; Subject Term: DISEASES -- Causes & theories of causation; Author-Supplied Keyword: Amplification-based typing methods; Author-Supplied Keyword: Gram-negative bacterial typing methods; Author-Supplied Keyword: Restriction-based typing; Author-Supplied Keyword: Sequencing-based typing; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.meegid.2009.03.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40115731&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bang, K. M.
AU - Mazurek, J. M.
AU - Storey, E.
AU - Attfield, M. D.
AU - Schleiff, P. L.
AU - Wood, J. M.
AU - Wassell, J. T.
T1 - Malignant Mesothelioma Mortality--United States, 1999-2005.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/07//7/1/2009
VL - 302
IS - 1
M3 - Article
SP - 25
EP - 26
SN - 00987484
AB - The article reports on an analysis conducted by the U.S. National Institute for Occupational Safety and Health (NIOSH) on annual multiple-cause-of-death records for 1999 to 2005 in the U.S. to characterize mortality attributed to mesothelioma. According to death records, a total of 18,068 of individuals with malignant mesothelioma were reported in the U.S. during the period, reflecting an increase from 2,482 deaths in 1999. These figures reported during the period are said to have indicated that potential exposure to asbestos continues.
KW - MESOTHELIOMA
KW - ASBESTOS -- Toxicology
KW - MORTALITY
KW - INDUSTRIAL hygiene
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 42739710; Bang, K. M. 1 Mazurek, J. M. 1 Storey, E. 1 Attfield, M. D. 1 Schleiff, P. L. 1 Wood, J. M. 1 Wassell, J. T. 2; Affiliation: 1: Div of Respiratory Disease Studies 2: Div of Safety Research, National Institute for Occupational Safety and Health, CDC; Source Info: 7/1/2009, Vol. 302 Issue 1, p25; Subject Term: MESOTHELIOMA; Subject Term: ASBESTOS -- Toxicology; Subject Term: MORTALITY; Subject Term: INDUSTRIAL hygiene; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rehermann, Barbara
T1 - Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2009/07//
VL - 119
IS - 7
M3 - journal article
SP - 1745
EP - 1754
SN - 00219738
AB - Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system. Much has been learned from HCV itself, which, via decades of coevolution, gained an intricate knowledge of host innate and adaptive immune responses and developed sophisticated ways to preempt, subvert, and antagonize them. This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - IMMUNE response
KW - IMMUNE system
KW - HEPATITIS C
KW - COEVOLUTION
N1 - Accession Number: 43314611; Rehermann, Barbara 1; Email Address: rehermann@nih.gov; Affiliation: 1: Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland, USA; Source Info: Jul2009, Vol. 119 Issue 7, p1745; Subject Term: HEPATITIS C virus; Subject Term: IMMUNE response; Subject Term: IMMUNE system; Subject Term: HEPATITIS C; Subject Term: COEVOLUTION; Number of Pages: 10p; Illustrations: 2 Diagrams, 1 Graph; Document Type: journal article
L3 - 10.1172/JCI39133
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43314611&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kornhauser, Andrija
AU - Wei, Rong-Rong
AU - Yamaguchi, Yuji
AU - Coelho, Sergio G.
AU - Kaidbey, Kays
AU - Barton, Curtis
AU - Takahashi, Kaoruko
AU - Beer, Janusz Z.
AU - Miller, Sharon A.
AU - Hearing, Vincent J.
T1 - The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
Y1 - 2009/07//
VL - 55
IS - 1
M3 - Article
SP - 10
EP - 17
SN - 09231811
AB - Abstract: Background: α-Hydroxy acids (αHAs) are reported to reduce signs of aging in the skin and are widely used cosmetic ingredients. Several studies suggest that αHA can increase the sensitivity of skin to ultraviolet radiation. More recently, β-hydroxy acids (βHAs), or combinations of αHA and βHA have also been incorporated into antiaging skin care products. Concerns have also arisen about increased sensitivity to ultraviolet radiation following use of skin care products containing β-HA. Objective: To determine whether topical treatment with glycolic acid, a representative αHA, or with salicylic acid, a βHA, modifies the short-term effects of solar simulated radiation (SSR) in human skin. Methods: Fourteen subjects participated in this study. Three of the four test sites on the mid-back of each subject were treated daily Monday–Friday, for a total of 3.5 weeks, with glycolic acid (10%), salicylic acid (2%), or vehicle (control). The fourth site received no treatment. After the last treatment, each site was exposed to SSR, and shave biopsies from all four sites were obtained. The endpoints evaluated in this study were erythema (assessed visually and instrumentally), DNA damage and sunburn cell formation. Results: Treatment with glycolic acid resulted in increased sensitivity of human skin to SSR, measured as an increase in erythema, DNA damage and sunburn cell formation. Salicylic acid did not produce significant changes in any of these biomarkers. Conclusions: Short-term topical application of glycolic acid in a cosmetic formulation increased the sensitivity of human skin to SSR, while a comparable treatment with salicylic acid did not. [Copyright &y& Elsevier]
AB - Copyright of Journal of Dermatological Science is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYDROXY acids
KW - SALICYLIC acid
KW - SKIN -- Aging
KW - ULTRAVIOLET radiation
KW - Cosmetics
KW - DNA damage
KW - Erythema
KW - Glycolic acid
KW - Hydroxyacids
KW - Salicylic acid
KW - Sunburn cells
KW - UV-damage
N1 - Accession Number: 40635059; Kornhauser, Andrija 1; Email Address: akornhause@aol.com Wei, Rong-Rong 1 Yamaguchi, Yuji 2 Coelho, Sergio G. 2 Kaidbey, Kays 3 Barton, Curtis 1 Takahashi, Kaoruko 2 Beer, Janusz Z. 4 Miller, Sharon A. 4 Hearing, Vincent J. 2; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA 2: Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 3: Ivy Laboratories (KGL Inc.), 505 Parkway, Broomall, PA 19008, USA 4: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA; Source Info: Jul2009, Vol. 55 Issue 1, p10; Subject Term: HYDROXY acids; Subject Term: SALICYLIC acid; Subject Term: SKIN -- Aging; Subject Term: ULTRAVIOLET radiation; Author-Supplied Keyword: Cosmetics; Author-Supplied Keyword: DNA damage; Author-Supplied Keyword: Erythema; Author-Supplied Keyword: Glycolic acid; Author-Supplied Keyword: Hydroxyacids; Author-Supplied Keyword: Salicylic acid; Author-Supplied Keyword: Sunburn cells; Author-Supplied Keyword: UV-damage; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jdermsci.2009.03.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40635059&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - STEFANIAK, ALEKSANDR B.
AU - VIRJI, M. ABBAS
AU - DAY, GREGORY A.
T1 - Characterization of exposures among cemented tungsten carbide workers. Part I: Size-fractionated exposures to airborne cobalt and tungsten particles.
JO - Journal of Exposure Science & Environmental Epidemiology
JF - Journal of Exposure Science & Environmental Epidemiology
Y1 - 2009/07//Jul/Aug2009
VL - 19
IS - 5
M3 - Article
SP - 475
EP - 491
PB - Nature Publishing Group
SN - 15590631
AB - As many as 30,000 workers in the United States of America are exposed to cemented tungsten carbides (CTC), alloys composed primarily of tungsten carbide and cobalt, which are used in cutting tools. Inhalation of cobalt-containing particles may be sufficient for the development of occupational asthma, whereas tungsten carbide particles in association with cobalt particles are associated with the development of hard metal disease (HMD) and lung cancer. Historical epidemiology and exposure studies of CTC workers often rely only on measures of total airborne cobalt mass concentration. In this study, we characterized cobalt- and tungsten-containing aerosols generated during the production of CTC with emphasis on (1) aerosol “total” mass (n=252 closed-face 37 mm cassette samples) and particle size-selective mass concentrations (n=108 eight-stage cascade impactor samples); (2) particle size distributions; and (3) comparison of exposures obtained using personal cassette and impactor samplers. Total cobalt and tungsten exposures were highest in work areas that handled powders (e.g., powder mixing) and lowest in areas that handled finished product (e.g., grinding). Inhalable, thoracic, and respirable cobalt and tungsten exposures were observed in all work areas, indicating potential for co-exposures to particles capable of getting deposited in the upper airways and alveolar region of the lung. Understanding the risk of CTC-induced adverse health effects may require two exposure regimes: one for asthma and the other for HMD and lung cancer. All sizes of cobalt-containing particles that deposit in the lung and airways have potential to cause asthma, thus a thoracic exposure metric is likely biologically appropriate. Cobalt-tungsten mixtures that deposit in the alveolar region of the lung may potentially cause HMD and lung cancer, thus a respirable exposure metric for both metals is likely biologically appropriate. By characterizing size-selective and co-exposures as well as multiple exposure pathways, this series of papers offer an approach for developing biologically meaningful exposure metrics for use in epidemiology.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 475–491; doi:10.1038/jes.2008.37; published online 16 July 2008 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Exposure Science & Environmental Epidemiology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PULMONARY toxicology
KW - AEROSOLS (Sprays)
KW - ASTHMA
KW - LUNG diseases
KW - LUNGS -- Cancer
KW - TUNGSTEN
KW - aerosols
KW - asthma
KW - exposure assessment
KW - lung cancer
KW - lung disease
KW - size-selective sampling
N1 - Accession Number: 41789410; STEFANIAK, ALEKSANDR B. 1; Email Address: astefaniak@cdc.gov VIRJI, M. ABBAS 1 DAY, GREGORY A. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA; Source Info: Jul/Aug2009, Vol. 19 Issue 5, p475; Subject Term: PULMONARY toxicology; Subject Term: AEROSOLS (Sprays); Subject Term: ASTHMA; Subject Term: LUNG diseases; Subject Term: LUNGS -- Cancer; Subject Term: TUNGSTEN; Author-Supplied Keyword: aerosols; Author-Supplied Keyword: asthma; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: lung cancer; Author-Supplied Keyword: lung disease; Author-Supplied Keyword: size-selective sampling; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 17p; Illustrations: 8 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/jes.2008.37
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41789410&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waters, Erika A.
AU - Sullivan, Helen W.
AU - Finney Rutten, Lila J.
T1 - Cancer Prevention Information-Seeking Among Hispanic and Non-Hispanic Users of the National Cancer Institute's Cancer Information Service: Trends in Telephone and LiveHelp Use.
JO - Journal of Health Communication
JF - Journal of Health Communication
Y1 - 2009/07//
VL - 14
IS - 5
M3 - Article
SP - 476
EP - 486
SN - 10810730
AB - Evidence-based strategies to enable, encourage, and support cancer prevention information seeking among Hispanic populations are needed. We examined cancer prevention information requests to the Cancer Information Service (CIS) via telephone (1-800-4-CANCER toll-free telephone information service) and LiveHelp (an instant messaging service provided in English only) from 2003 to 2006. We summarized differences in the communication channel utilized by ethnicity (Hispanic vs. non-Hispanic) and, among Hispanic information seekers, the language used during the contact (English vs. Spanish). Utilization of LiveHelp was higher among non-Hispanic than Hispanic seekers of cancer prevention information. LiveHelp use for seeking cancer prevention information increased between 2003 and 2006 for both groups, but the increase was greater among non-Hispanics than Hispanics. Nearly half of Hispanics who sought cancer prevention information did so in Spanish. Because LiveHelp is not available in Spanish, the number of Spanish-only speakers who preferred to contact CIS via LiveHelp instead of telephone is unknown. When communicating cancer prevention information via multiple channels, it is important to consider differences in access to communication technologies and preferred communication channels among ethnic minority groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Communication is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CANCER prevention
KW - INFORMATION services
KW - HISPANIC Americans -- Communication
KW - LANGUAGE services
KW - LANGUAGE policy
KW - SOCIAL aspects
KW - UNITED States
KW - NATIONAL Cancer Institute (U.S.)
N1 - Accession Number: 43578348; Waters, Erika A. 1 Sullivan, Helen W. 2 Finney Rutten, Lila J. 1; Affiliation: 1: Health Communication and Informatics Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA 2: Health Communication and Informatics Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA,U.S. Food and Drug Administration,; Source Info: Jul2009, Vol. 14 Issue 5, p476; Subject Term: CANCER prevention; Subject Term: INFORMATION services; Subject Term: HISPANIC Americans -- Communication; Subject Term: LANGUAGE services; Subject Term: LANGUAGE policy; Subject Term: SOCIAL aspects; Subject Term: UNITED States; Company/Entity: NATIONAL Cancer Institute (U.S.); NAICS/Industry Codes: 519190 All Other Information Services; NAICS/Industry Codes: 541930 Translation and Interpretation Services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 11p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/10810730903032952
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43578348&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Tryndyak, Volodymyr P.
AU - Bagnyukova, Tetyana V.
AU - Melnyk, Stepan
AU - Montgomery, Beverly
AU - Ross, Sharon A.
AU - Latendresse, John R.
AU - Rusyn, Ivan
AU - Beland, Frederick A.
T1 - Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009/07//
VL - 51
IS - 1
M3 - Article
SP - 176
EP - 186
SN - 01688278
AB - Background/Aims: The importance of epigenetic changes in etiology and pathogenesis of disease has been increasingly recognized. However, the role of epigenetic alterations in the genesis of hepatic steatosis and cause of individual susceptibilities to this pathological state are largely unknown. Methods: Male inbred C57BL/6J and DBA/2J mice were fed a lipogenic methyl-deficient diet (MDD) that causes liver injury similar to human non-alcoholic steatohepatitis (NASH) for 6, 12, or 18 weeks, and the status of global and repetitive elements cytosine methylation, histone modifications, and expression of proteins responsible for those epigenetic modifications in livers was determined. Results: The development of hepatic steatosis in inbred C57BL/6J and DBA/2J mice was accompanied by prominent epigenetic abnormalities. This was evidenced by pronounced loss of genomic and repetitive sequences cytosine methylation, especially at major and minor satellites, accompanied by increased levels of repeat-associated transcripts, aberrant histone modifications, and alterations in expression of the maintenance DNA methyltransferase 1 (DNMT1) and de novo DNMT3A proteins in the livers of both mouse strains. However, the DBA/2J mice, which were characterized by an initially lower degree of methylation of repetitive elements and lower extent of histone H3 lysine 9 (H3K9) and H3 lysine 27 (H3K27) trimethylation in the normal livers, as compared to those in the C57BL/6J mice, developed more prominent NASH-specific pathomorphological changes. Conclusions: These results mechanistically link epigenetic alterations to the pathogenesis of hepatic steatosis and strongly suggest that differences in the cellular epigenetic status may be a predetermining factor to individual susceptibilities to hepatic steatosis. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hepatology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FATTY liver
KW - PHENOTYPE
KW - DISEASE susceptibility
KW - MICE as laboratory animals
KW - DIET in disease
KW - DISEASES -- Causes & theories of causation
KW - METHYLATION
KW - MEDICAL genetics
KW - analysis of variance ( ANOVA )
KW - carnitine palmitoyltransferase 1 ( Cpt1 )
KW - Disease susceptibility
KW - DNA methylation
KW - DNA methyltransferase ( DNMT )
KW - glyceraldehyde-3-phosphate dehydrogenase ( Gapdh )
KW - Hepatic steatosis
KW - histone H3 lysine 27 ( H3K27 )
KW - histone H3 lysine 9 ( H3K9 )
KW - histone H4 lysine 20 ( H4K20 )
KW - histone lysine methyltransferase ( KMT )
KW - Histone modifications
KW - intracesternal A particle ( IAP )
KW - long interspersed element ( LINE )
KW - long-chain fatty acid ( LCFA )
KW - methyl-adequate diet ( MAD )
KW - methyl-deficient diet ( MDD )
KW - Non-alcoholic steatohepatitis
KW - non-alcoholic steatohepatitis ( NASH )
KW - quantitative real-time-PCR ( qRT-PCR )
KW - S-adenosyl-l-homocysteine ( SAH )
KW - S-adenosyl-l-methionine ( SAM )
KW - short interspersed element ( SINE )
N1 - Accession Number: 41239567; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Tryndyak, Volodymyr P. 1 Bagnyukova, Tetyana V. 1 Melnyk, Stepan 2 Montgomery, Beverly 1 Ross, Sharon A. 3 Latendresse, John R. 4 Rusyn, Ivan 5 Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA 3: Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA 4: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR, USA 5: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA; Source Info: Jul2009, Vol. 51 Issue 1, p176; Subject Term: FATTY liver; Subject Term: PHENOTYPE; Subject Term: DISEASE susceptibility; Subject Term: MICE as laboratory animals; Subject Term: DIET in disease; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: METHYLATION; Subject Term: MEDICAL genetics; Author-Supplied Keyword: analysis of variance ( ANOVA ); Author-Supplied Keyword: carnitine palmitoyltransferase 1 ( Cpt1 ); Author-Supplied Keyword: Disease susceptibility; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: DNA methyltransferase ( DNMT ); Author-Supplied Keyword: glyceraldehyde-3-phosphate dehydrogenase ( Gapdh ); Author-Supplied Keyword: Hepatic steatosis; Author-Supplied Keyword: histone H3 lysine 27 ( H3K27 ); Author-Supplied Keyword: histone H3 lysine 9 ( H3K9 ); Author-Supplied Keyword: histone H4 lysine 20 ( H4K20 ); Author-Supplied Keyword: histone lysine methyltransferase ( KMT ); Author-Supplied Keyword: Histone modifications; Author-Supplied Keyword: intracesternal A particle ( IAP ); Author-Supplied Keyword: long interspersed element ( LINE ); Author-Supplied Keyword: long-chain fatty acid ( LCFA ); Author-Supplied Keyword: methyl-adequate diet ( MAD ); Author-Supplied Keyword: methyl-deficient diet ( MDD ); Author-Supplied Keyword: Non-alcoholic steatohepatitis; Author-Supplied Keyword: non-alcoholic steatohepatitis ( NASH ); Author-Supplied Keyword: quantitative real-time-PCR ( qRT-PCR ); Author-Supplied Keyword: S-adenosyl-l-homocysteine ( SAH ); Author-Supplied Keyword: S-adenosyl-l-methionine ( SAM ); Author-Supplied Keyword: short interspersed element ( SINE ); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.jhep.2009.03.021
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Roberts, C.
AU - Roberts, J.
AU - Roberts, R. J.
T1 - Investigation into the effect of an alcohol-based hand product on infection rate in a nursing home setting.
JO - Journal of Infection Prevention
JF - Journal of Infection Prevention
Y1 - 2009/07//
VL - 10
IS - 4
M3 - Article
SP - 138
EP - 142
SN - 17571774
AB - The article discusses a study on the effect of a personal alcohol-based hand product (ABHP) on infection rates among the staff in a nursing home (NH) with or without training on its use. Fifteen North Wales NH were grouped into three and were monitored on infection rates for an 18 week period. The methods used, the results of the study and recommendations were discussed. The study found that the provision of ABHP did not yield statistically significant reductions in infection and were therefore inconclusive.
KW - NURSING home employees
KW - NURSES -- Health
KW - INDUSTRIAL hygiene
KW - ALCOHOL
KW - INFECTION -- Prevention
KW - alcohol based hand product
KW - Infection rate
KW - nursing homes
N1 - Accession Number: 45046449; Roberts, C. 1 Roberts, J. 2 Roberts, R. J. 3; Affiliation: 1: Health Protection Nurse, North Wales Health Protection Team, National Public Health Service for Wales 2: Principal Lecturer, Psychology, School of Health and Social Care, Glyndwr University, Wrexham 3: Head Vaccine Preventable Disease Programme, National Public Health Service for Wales; Source Info: Jul2009, Vol. 10 Issue 4, p138; Subject Term: NURSING home employees; Subject Term: NURSES -- Health; Subject Term: INDUSTRIAL hygiene; Subject Term: ALCOHOL; Subject Term: INFECTION -- Prevention; Author-Supplied Keyword: alcohol based hand product; Author-Supplied Keyword: Infection rate; Author-Supplied Keyword: nursing homes; NAICS/Industry Codes: 325193 Ethyl Alcohol Manufacturing; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105413896
T1 - Investigation into the effect of an alcohol-based hand product on infection rate in a nursing home setting.
AU - Roberts S
AU - Roberts J
AU - Roberts RJ
Y1 - 2009/07//
N1 - Accession Number: 105413896. Language: English. Entry Date: 20091009. Revision Date: 20150819. Publication Type: Journal Article; clinical trial; equations & formulas; research; tables/charts. Journal Subset: Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Nursing; Peer Reviewed; UK & Ireland. Special Interest: Gerontologic Care. NLM UID: 101469725.
KW - Cross Infection -- Prevention and Control
KW - Gels
KW - Handwashing -- Education
KW - Nursing Home Patients -- Education
KW - Patient Education -- Evaluation
KW - Clinical Trials
KW - Convenience Sample
KW - Cross Infection -- Epidemiology
KW - Descriptive Statistics
KW - Experimental Studies
KW - National Health Programs -- Wales
KW - Nursing Homes
KW - Paired T-Tests
KW - Random Assignment
KW - Surveys
KW - Wales
KW - Human
SP - 138
EP - 142
JO - Journal of Infection Prevention
JF - Journal of Infection Prevention
JA - J INFECT PREV
VL - 10
IS - 4
PB - Sage Publications, Ltd.
AB - The study assessed the impact on nursing home (NH) resident infection rates of providing staff with a personal alcohol-based hand product (ABHP) with and without training on its use.Fifteen North Wales NHs were recruited and randomly allocated into one of three groups. All monitored infection rates throughout the study period of 18 weeks (Phase I [weeks 1-9], Phase II [weeks 11-19]). NHs used liquid soap and water for hand washing throughout the study. Groups B and C introduced interventions during week ten: Group B were provided with personal ABHPs without training on use; Group C personal ABHPs with standard training from the sponsoring hand hygiene company. Infection rates between groups and pre- and post-intervention were compared.Infection rates (per 1,000 bed days) for Phase I vs. Phase II of the study were: Group A: 6.99 vs. 7.16; Group B: 6.08 vs. 3.46; and Group C: 5.04 vs. 6.78 respectively. Change in infection rates in Groups B and C pre- and post-intervention did not reach statistical significance, p = 0.097 and p = 0.072 respectively.Comparison of rates in non-intervention Group A with the intervention groups indicated a significantly lower rate after the intervention in Group B (p = 0.035) but not Group C (p = 0.765).Findings are limited due to sample size; introduction of personal ABHPs with training did not reduce infection rates. This conflicts with other studies examining education and improvement of hand hygiene compliance. However, infection rates fell in NHs not receiving training, possibly mediated through a sense of 'ownership' of the intervention.
SN - 1757-1774
AD - North Wales Health Protection Team, National Public Health Service for Wales, carol.roberts@nphs.wales.nhs.uk
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Yuan, Liming
AU - Smith, Alex C.
T1 - CFD modeling of spontaneous heating in a large-scale coal chamber
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2009/07//
VL - 22
IS - 4
M3 - Article
SP - 426
EP - 433
SN - 09504230
AB - Abstract: Three-dimensional computational fluid dynamics (CFD) modeling is conducted to simulate spontaneous heating in a large-scale coal chamber with a forced ventilation system. Spontaneous heating is modeled as the low-temperature oxidation of coal using kinetic data obtained from previous laboratory-scale spontaneous heating studies. Heat generated from coal oxidation is dissipated by convection and conduction, while oxygen and oxidation products are transported by convection and diffusion. The water vapor transfer and the effect of heat of wetting are not modeled. The CFD model is validated by comparing simulation results with test results from U.S. Bureau of Mines experiments conducted in the coal chamber. The model predicts lower temperatures in the early stage but agrees well on the induction time for spontaneous heating. The effects of airflow rate and order of reaction on the spontaneous heating process are also examined. The calibrated CFD model is found to be useful for predicting the induction time for spontaneous heating in underground coal mines. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL
KW - FUEL
KW - FOSSIL fuels
KW - CAUSTOBIOLITHS
KW - CFD Modeling
KW - Coal
KW - Spontaneous heating
KW - Temperature
N1 - Accession Number: 41241313; Yuan, Liming; Email Address: lcy6@cdc.gov; Smith, Alex C. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, USA; Issue Info: Jul2009, Vol. 22 Issue 4, p426; Subject Term: COAL; Subject Term: FUEL; Subject Term: FOSSIL fuels; Subject Term: CAUSTOBIOLITHS; Author-Supplied Keyword: CFD Modeling; Author-Supplied Keyword: Coal; Author-Supplied Keyword: Spontaneous heating; Author-Supplied Keyword: Temperature; NAICS/Industry Codes: 418990 All other merchant wholesalers; NAICS/Industry Codes: 454310 Fuel Dealers; NAICS/Industry Codes: 454319 Other fuel dealers; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jlp.2009.02.016
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Zlochower, Isaac A.
AU - Green, Gregory M.
T1 - The limiting oxygen concentration and flammability limits of gases and gas mixtures
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2009/07//
VL - 22
IS - 4
M3 - Article
SP - 499
EP - 505
SN - 09504230
AB - Abstract: This paper presents data on the limiting (minimum) oxygen concentration (LOC), in the presence of added N2, of methane (CH4), propane (C3H8), ethylene (C2H4), carbon monoxide (CO), and hydrogen (H2), and some of their binary mixtures. It also addresses the issue of the flammable concentration (flammability) limits of these pure gases in air. The study is based on spark ignited explosions in large, spherical laboratory vessels (120-L and 20-L) using a 7% pressure-rise criterion for explosion propagation. The results of the study are compared with the older values which used long flammability tubes with a diameter ≥5 cm together with visual evidence of substantial upward propagation. They are also compared to results reported recently using a 12-L spherical flask with a visual flame propagation criterion. Finally, they are compared to results reported in Europe using more modest flammability criteria and smaller chambers. The findings reported here show excellent agreement between the 120-L and 12-L results, good agreement with the 20-L results, and reasonable agreement with the earlier flammability tube values for the lower flammability limits. They disagree, however, with the more conservative European values. These results and those from the 12-L experiments also feature lower LOCs than are given by traditional flammability tubes. A model for the LOCs of such fuel mixtures based on the Le Chatelier mixture rule for lower flammable limits is seen to reasonably fit the observed results on binary mixtures and can accommodate more complex mixtures as well. One such set of ternary mixtures containing CH4 and 1:1 CO:H2 is well fitted by the model. [Copyright &y& Elsevier]
AB - Copyright of Journal of Loss Prevention in the Process Industries is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAMMABILITY
KW - FIRE
KW - MATTER -- Properties
KW - COMBUSTION
KW - Flammable
KW - Gas
KW - LFL
KW - LOC
KW - Mixture
KW - UFL
N1 - Accession Number: 41241323; Zlochower, Isaac A.; Email Address: iaz0@cdc.gov; Green, Gregory M. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA; Issue Info: Jul2009, Vol. 22 Issue 4, p499; Subject Term: FLAMMABILITY; Subject Term: FIRE; Subject Term: MATTER -- Properties; Subject Term: COMBUSTION; Author-Supplied Keyword: Flammable; Author-Supplied Keyword: Gas; Author-Supplied Keyword: LFL; Author-Supplied Keyword: LOC; Author-Supplied Keyword: Mixture; Author-Supplied Keyword: UFL; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jlp.2009.03.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=41241323&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - GEN
AU - Yuan, Liming
AU - Smith, Alex C.
T1 - Response to “Letter to the Editor: Spontaneous heating of a coal stockpile” by J.C. Jones
JO - Journal of Loss Prevention in the Process Industries
JF - Journal of Loss Prevention in the Process Industries
Y1 - 2009/07//
VL - 22
IS - 4
M3 - Letter
SP - 554
EP - 554
SN - 09504230
N1 - Accession Number: 41241332; Yuan, Liming; Email Address: lcy6@cdc.gov; Smith, Alex C. 1; Affiliations: 1: Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Cochrans Mill Road, Pittsburgh, PA 15236, United States; Issue Info: Jul2009, Vol. 22 Issue 4, p554; Number of Pages: 1p; Document Type: Letter
L3 - 10.1016/j.jlp.2009.04.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=41241332&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105366876
T1 - Complexity, bullying, and stress: analyzing and mitigating a challenging work environment for nurses.
AU - Hughes RG
AU - Clancy CM
Y1 - 2009/07//2009 Jul-Sep
N1 - Accession Number: 105366876. Language: English. Entry Date: 20090807. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology; Quality Assurance. NLM UID: 9200672.
KW - Bullying
KW - Nurses -- Psychosocial Factors
KW - Stress, Occupational
KW - Decision Making
KW - Professional Autonomy
KW - Quality of Working Life
KW - Work Environment
SP - 180
EP - 183
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 24
IS - 3
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850; Ronda.Hughes@ahrq.hhs.gov
U2 - PMID: 19525756.
DO - 10.1097/NCQ.0b013e3181a6350a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105366876&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zaebst, D. D.
AU - Seel, E. A.
AU - Yiin, J. H.
AU - Nowlin, S. J.
AU - Chen, P.
T1 - Summary of Retrospective Asbestos and Welding Fume Exposure Estimates for a Nuclear Naval Shipyard and Their Correlation with Radiation Exposure Estimates.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/07//
VL - 6
IS - 7
M3 - Article
SP - 404
EP - 414
PB - Taylor & Francis Ltd
SN - 15459624
AB - In support of a nested case-control study at a U.S. naval shipyard, the results of the reconstruction of historical exposures were summarized, and an analysis was undertaken to determine the impact of historical exposures to potential chemical confounders. The nested case-control study (N = 4388) primarily assessed the relationship between lung cancer and external ionizing radiation. Chemical confounders considered important were asbestos and welding fume (as iron oxide fume), and the chromium and nickel content of welding fume. Exposures to the potential confounders were estimated by an expert panel based on a set of quantitatively defined categories of exposure. Distributions of the estimated exposures and trends in exposures over time were examined for the study population. Scatter plots and Spearman rank correlation coefficients were used to assess the degree of association between the estimates of exposure to asbestos, welding fume, and ionizing radiation. Correlation coefficients were calculated separately for 0-, 15-, 20-, and 25-year time-lagged cumulative exposures, total radiation dose (which included medical X-ray dose) and occupational radiation dose. Exposed workers' estimated cumulative exposures to asbestos ranged from 0.01 fiber-days/cm3 to just under 20,000 fiber-days/cm3, with a median of 29.0 fiber-days/cm3. Estimated cumulative exposures to welding fume ranged from 0.16 mg-days/m3 to just over 30,000 mg-days/m3, with a median of 603 mg-days/m3. Spearman correlation coefficients between cumulative radiation dose and cumulative asbestos exposures ranged from 0.09 (occupational dose) to 0.47 (total radiation dose), and those between radiation and welding fume from 0.14 to 0.47. The estimates of relative risk for ionizing radiation and lung cancer were unchanged when lowest and highest estimates of asbestos and welding fume were considered. These results suggest a fairly large proportion of study population workers were exposed to asbestos and welding fume, that the absolute level of confounding exposure did not affect the risk estimates, and that weak relationships existed between monitored lifetime cumulative occupational radiation dose and asbestos or welding fume. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Industrial hygiene
KW - Air pollution
KW - Industrial pollution
KW - Radiation
KW - Naval bases -- Environmental aspects
KW - Asbestos -- Environmental aspects
KW - Welding fumes
KW - United States
KW - confounding
KW - exposure assessment
KW - lung cancer
N1 - Accession Number: 39054385; Zaebst, D. D. 1; Email Address: ddz1@cdc.gov; Seel, E. A. 1; Yiin, J. H. 1; Nowlin, S. J. 1; Chen, P. 1; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jul2009, Vol. 6 Issue 7, p404; Thesaurus Term: Industrial safety; Thesaurus Term: Industrial hygiene; Thesaurus Term: Air pollution; Thesaurus Term: Industrial pollution; Thesaurus Term: Radiation; Subject Term: Naval bases -- Environmental aspects; Subject Term: Asbestos -- Environmental aspects; Subject Term: Welding fumes; Subject: United States; Author-Supplied Keyword: confounding; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: lung cancer; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 928110 National Security; NAICS/Industry Codes: 911110 Defence services; Number of Pages: 11p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1080/15459620902922573
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lawryk, Nicholas J.
AU - Feng, H. Amy
AU - Chen, Bean T.
T1 - Laboratory Evaluation of a Field-Portable Sealed Source X-Ray Fluorescence Spectrometer for Determination of Metals in Air Filter Samples.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/07//
VL - 6
IS - 7
M3 - Article
SP - 433
EP - 445
PB - Taylor & Francis Ltd
SN - 15459624
AB - Recent advances in field-portable X-ray fluorescence (FP XRF) spectrometer technology have made it a potentially valuable screening tool for the industrial hygienist to estimate worker exposures to airborne metals. Although recent studies have shown that FP XRF technology may be better suited for qualitative or semiquantitative analysis of airborne lead in the workplace, these studies have not extensively addressed its ability to measure other elements. This study involved a laboratory-based evaluation of a representative model FP XRF spectrometer to measure elements commonly encountered in workplace settings that may be collected on air sample filter media, including chromium, copper, iron, manganese, nickel, lead, and zinc. The evaluation included assessments of (1) response intensity with respect to location on the probe window, (2) limits of detection for five different filter media, (3) limits of detection as a function of analysis time, and (4) bias, precision, and accuracy estimates. Teflon, polyvinyl chloride, polypropylene, and mixed cellulose ester filter media all had similarly low limits of detection for the set of elements examined. Limits of detection, bias, and precision generally improved with increasing analysis time. Bias, precision, and accuracy estimates generally improved with increasing element concentration. Accuracy estimates met the National Institute for Occupational Safety and Health criterion for nearly all the element and concentration combinations. Based on these results, FP XRF spectrometry shows potential to be useful in the assessment of worker inhalation exposures to other metals in addition to lead. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial hygiene
KW - Industrial safety
KW - Metals -- Environmental aspects
KW - Air pollution -- Prevention
KW - Air filters
KW - Dust control
KW - Spectrum analysis
KW - X-ray spectroscopy
KW - accuracy
KW - bias
KW - metalworking
KW - precision
KW - welding
N1 - Accession Number: 39054383; Lawryk, Nicholas J. 1; Email Address: NLawryk@cdc.gov; Feng, H. Amy 2; Chen, Bean T. 1; Affiliations: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 2: Communications and Statistical Team, National Institute for Occupational Safety and Health, Cincinnati, Ohio; Issue Info: Jul2009, Vol. 6 Issue 7, p433; Thesaurus Term: Industrial hygiene; Thesaurus Term: Industrial safety; Thesaurus Term: Metals -- Environmental aspects; Thesaurus Term: Air pollution -- Prevention; Thesaurus Term: Air filters; Thesaurus Term: Dust control; Thesaurus Term: Spectrum analysis; Subject Term: X-ray spectroscopy; Author-Supplied Keyword: accuracy; Author-Supplied Keyword: bias; Author-Supplied Keyword: metalworking; Author-Supplied Keyword: precision; Author-Supplied Keyword: welding; NAICS/Industry Codes: 238220 Plumbing, Heating, and Air-Conditioning Contractors; NAICS/Industry Codes: 238290 Other Building Equipment Contractors; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; NAICS/Industry Codes: 332812 Metal Coating, Engraving (except Jewelry and Silverware), and Allied Services to Manufacturers; NAICS/Industry Codes: 332811 Metal Heat Treating; Number of Pages: 13p; Illustrations: 2 Diagrams, 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1080/15459620902932119
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=39054383&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105512480
T1 - Summary of retrospective asbestos and welding fume exposure estimates for a nuclear naval shipyard and their correlation with radiation exposure estimates.
AU - Zaebst DD
AU - Seel EA
AU - Yiin JH
AU - Nowlin SJ
AU - Chen P
Y1 - 2009/07//
N1 - Accession Number: 105512480. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Military/Uniformed Services. Grant Information: Funded by the US Department of Energy (DOE) and the US Department of Health and Human Services (DHHS). NLM UID: 101189458.
KW - Asbestos
KW - Construction Industry
KW - Metallurgy
KW - Occupational Exposure
KW - Radiation
KW - Ships
KW - United States Navy
KW - Case Control Studies
KW - Chromium -- Analysis
KW - Confidence Intervals
KW - Confounding Variable
KW - Data Analysis Software
KW - Education, Continuing (Credit)
KW - Funding Source
KW - Iron Compounds -- Analysis
KW - Logistic Regression
KW - Lung Neoplasms -- Risk Factors
KW - Maine
KW - Multivariate Analysis
KW - Nickel -- Analysis
KW - Nonparametric Statistics
KW - Nuclear Reactors
KW - Odds Ratio
KW - Relative Risk
KW - Retrospective Design
KW - Spearman's Rank Correlation Coefficient
KW - Human
SP - 404
EP - 414
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - In support of a nested case-control study at a U.S. naval shipyard, the results of the reconstruction of historical exposures were summarized, and an analysis was undertaken to determine the impact of historical exposures to potential chemical confounders. The nested case-control study (N = 4388) primarily assessed the relationship between lung cancer and external ionizing radiation. Chemical confounders considered important were asbestos and welding fume (as iron oxide fume), and the chromium and nickel content of welding fume. Exposures to the potential confounders were estimated by an expert panel based on a set of quantitatively defined categories of exposure. Distributions of the estimated exposures and trends in exposures over time were examined for the study population. Scatter plots and Spearman rank correlation coefficients were used to assess the degree of association between the estimates of exposure to asbestos, welding fume, and ionizing radiation. Correlation coefficients were calculated separately for 0-, 15-, 20-, and 25-year time-lagged cumulative exposures, total radiation dose (which included medical X-ray dose) and occupational radiation dose. Exposed workers' estimated cumulative exposures to asbestos ranged from 0.01 fiber-days/cm(3) to just under 20,000 fiber-days/cm(3), with a median of 29.0 fiber-days/cm(3). Estimated cumulative exposures to welding fume ranged from 0.16 mg-days/m(3) to just over 30,000 mg-days/m(3), with a median of 603 mg-days/m(3). Spearman correlation coefficients between cumulative radiation dose and cumulative asbestos exposures ranged from 0.09 (occupational dose) to 0.47 (total radiation dose), and those between radiation and welding fume from 0.14 to 0.47. The estimates of relative risk for ionizing radiation and lung cancer were unchanged when lowest and highest estimates of asbestos and welding fume were considered. These results suggest a fairly large proportion of study population workers were exposed to asbestos and welding fume, that the absolute level of confounding exposure did not affect the risk estimates, and that weak relationships existed between monitored lifetime cumulative occupational radiation dose and asbestos or welding fume.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. ddz1@cdc.gov
U2 - PMID: 19378213.
DO - 10.1080/15459620902922573
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105512480&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105512479
T1 - Laboratory evaluation of a field-portable sealed source x-ray fluorescence spectrometer for determination of metals in air filter samples.
AU - Lawryk NJ
AU - Feng HA
AU - Chen BT
Y1 - 2009/07//
N1 - Accession Number: 105512479. Language: English. Entry Date: 20090612. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Air -- Analysis
KW - Environmental Monitoring -- Equipment and Supplies
KW - Environmental Monitoring -- Methods
KW - Metals -- Analysis
KW - Occupational Exposure -- Evaluation
KW - Spectrometry, X-Ray Emission -- Equipment and Supplies
KW - Spectrometry, X-Ray Emission -- Utilization
KW - Air Pollution
KW - Education, Continuing (Credit)
KW - One-Way Analysis of Variance
KW - Particulate Matter -- Analysis
KW - Time Factors
KW - Two-Way Analysis of Variance
KW - United States
KW - United States Occupational Safety and Health Administration
KW - Validity
KW - Human
SP - 433
EP - 445
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 7
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Recent advances in field-portable X-ray fluorescence (FP XRF) spectrometer technology have made it a potentially valuable screening tool for the industrial hygienist to estimate worker exposures to airborne metals. Although recent studies have shown that FP XRF technology may be better suited for qualitative or semiquantitative analysis of airborne lead in the workplace, these studies have not extensively addressed its ability to measure other elements. This study involved a laboratory-based evaluation of a representative model FP XRF spectrometer to measure elements commonly encountered in workplace settings that may be collected on air sample filter media, including chromium, copper, iron, manganese, nickel, lead, and zinc. The evaluation included assessments of (1) response intensity with respect to location on the probe window, (2) limits of detection for five different filter media, (3) limits of detection as a function of analysis time, and (4) bias, precision, and accuracy estimates. Teflon, polyvinyl chloride, polypropylene, and mixed cellulose ester filter media all had similarly low limits of detection for the set of elements examined. Limits of detection, bias, and precision generally improved with increasing analysis time. Bias, precision, and accuracy estimates generally improved with increasing element concentration. Accuracy estimates met the National Institute for Occupational Safety and Health criterion for nearly all the element and concentration combinations. Based on these results, FP XRF spectrometry shows potential to be useful in the assessment of worker inhalation exposures to other metals in addition to lead.
SN - 1545-9624
AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia.
U2 - PMID: 19387888.
DO - 10.1080/15459620902932119
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105512479&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105222639
T1 - Laboratory evaluation of carbon monoxide exposure in CO2 Arc welding.
AU - Ojima J
Y1 - 2009/07//
N1 - Accession Number: 105222639. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Asia; Biomedical. NLM UID: 9616320.
KW - Carbon Monoxide -- Administration and Dosage
KW - Carbon Monoxide Poisoning -- Diagnosis
KW - Diagnosis, Laboratory -- Equipment and Supplies
KW - Occupational Exposure -- Prevention and Control
KW - Metallurgy
KW - Carbon Monoxide -- Analysis
KW - Japan
SP - 377
EP - 379
JO - Journal of Occupational Health
JF - Journal of Occupational Health
JA - J OCCUP HEALTH
VL - 51
IS - 4
PB - Kyorinsha
SN - 1341-9145
AD - National Institute of Occupational Safety and Health, Japan. ojima@h.jniosh.go.jp
U2 - PMID: 19502769.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105222639&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Trepakova, Elena S.
AU - Koerner, John
AU - Pettit, Syril D.
AU - Valentin, Jean-Pierre
T1 - A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays
JO - Journal of Pharmacological & Toxicological Methods
JF - Journal of Pharmacological & Toxicological Methods
Y1 - 2009/07//
VL - 60
IS - 1
M3 - Article
SP - 45
EP - 50
SN - 10568719
AB - Abstract: Drug-induced ventricular arrhythmia and Torsades de Pointes remain a serious public health issues in bringing safe new pharmaceuticals to the market place. Under the auspices of the International Life Science Institute (ILSI)–Health and Environmental Sciences Institute (HESI), a consortium involving representatives from pharmaceutical companies, regulatory agencies and opinion leaders from the scientific and medical research communities has been initiated. The objectives are (1) to assess the concordance between signals in non-clinical repolarization assays and clinical QT interval prolongation; (2) to investigate the mechanisms for any discrepancy identified between non-clinical and clinical results and to determine viable and successful alternative approaches to identify these compounds; and (3) to assess the proarrhythmic potential of such compounds. At present, the consortium is conducting a retrospective analysis of non-clinical and clinical data from both FDA and contributing companies'' databases and supplementing with a literature review. The overall objectives of these initial efforts are to establish a quantitative integrated risk assessment for each compound; to define criteria for concordance and apply them to the database in order to identify non-concordant compounds. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmacological & Toxicological Methods is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Public health
KW - Biological assay
KW - TOXICOLOGY
KW - Data analysis
KW - Health risk assessment
KW - Arrhythmia -- Treatment
KW - Drugs -- Safety measures
KW - Medical research
KW - Retrospective studies
KW - Medical literature
KW - Drugs
KW - Pharmaceutical industry -- Societies, etc.
KW - Ventricular tachycardia
KW - Animal models
KW - Cardiac repolarization
KW - Cardiac safety
KW - delayed rectifier potassium current ( I Kr )
KW - duration of the QT interval of the electrocardiogram ( QT )
KW - Electrocardiogram ( ECG )
KW - First Time in Human ( FTIH )
KW - Food and Drug administration ( FDA )
KW - Good Laboratory Practice ( GLP )
KW - Health and Environmental Sciences Institute ( HESI )
KW - human ether-a-go-go related gene ( hERG )
KW - ILSI/HESI
KW - International Conference on Harmonization ( ICH )
KW - International Life Sciences Institute ( ILSI )
KW - Pro-Arrhythmia Models Project Committee
KW - QT
KW - QTc
KW - rate corrected QT interval duration ( QTc )
KW - Torsades de Pointes ( TdP )
N1 - Accession Number: 43768086; Trepakova, Elena S. 1; Email Address: elena_trepakova@merck.com; Koerner, John 2; Email Address: john.koerner@fda.hhs.gov; Pettit, Syril D. 3; Email Address: spettit@ilsi.org; Valentin, Jean-Pierre 4; Email Address: jean-pierre.valentin@astrazeneca.com; Affiliations: 1: Merck Research Laboratories, 770 Sumneytown Pike, PO Box 4, WP81-220, West Point, PA 19486, USA; 2: Division of Cardiovascular and Renal Products, Center of Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, WO-22, Suite 4178, Silver Spring, MD 20993-0002, USA; 3: Scientific Outreach, Health and Environmental Sciences Institute, 1156 15th Street, NW, 2nd floor, Washington, DC 20005, USA; 4: AstraZeneca R&D Alderley Park, Safety Assessment UK, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom; Issue Info: Jul2009, Vol. 60 Issue 1, p45; Thesaurus Term: Public health; Thesaurus Term: Biological assay; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Data analysis; Thesaurus Term: Health risk assessment; Subject Term: Arrhythmia -- Treatment; Subject Term: Drugs -- Safety measures; Subject Term: Medical research; Subject Term: Retrospective studies; Subject Term: Medical literature; Subject Term: Drugs; Subject Term: Pharmaceutical industry -- Societies, etc.; Subject Term: Ventricular tachycardia; Author-Supplied Keyword: Animal models; Author-Supplied Keyword: Cardiac repolarization; Author-Supplied Keyword: Cardiac safety; Author-Supplied Keyword: delayed rectifier potassium current ( I Kr ); Author-Supplied Keyword: duration of the QT interval of the electrocardiogram ( QT ); Author-Supplied Keyword: Electrocardiogram ( ECG ); Author-Supplied Keyword: First Time in Human ( FTIH ); Author-Supplied Keyword: Food and Drug administration ( FDA ); Author-Supplied Keyword: Good Laboratory Practice ( GLP ); Author-Supplied Keyword: Health and Environmental Sciences Institute ( HESI ); Author-Supplied Keyword: human ether-a-go-go related gene ( hERG ); Author-Supplied Keyword: ILSI/HESI; Author-Supplied Keyword: International Conference on Harmonization ( ICH ); Author-Supplied Keyword: International Life Sciences Institute ( ILSI ); Author-Supplied Keyword: Pro-Arrhythmia Models Project Committee; Author-Supplied Keyword: QT; Author-Supplied Keyword: QTc; Author-Supplied Keyword: rate corrected QT interval duration ( QTc ); Author-Supplied Keyword: Torsades de Pointes ( TdP ); NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vascn.2009.05.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43768086&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Myers, Matthew R.
AU - Soneson, Joshua E.
T1 - Temperature modes for nonlinear Gaussian beams.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2009/07//
VL - 126
IS - 1
M3 - Article
SP - 425
EP - 433
SN - 00014966
AB - In assessing the influence of nonlinear acoustic propagation on thermal bioeffects, approximate methods for quickly estimating the temperature rise as operational parameters are varied can be very useful. This paper provides a formula for the transient temperature rise associated with nonlinear propagation of Gaussian beams. The pressure amplitudes for the Gaussian modes can be obtained rapidly using a method previously published for simulating nonlinear propagation of Gaussian beams. The temperature-mode series shows that the nth temperature mode generated by nonlinear propagation, when normalized by the fundamental, is weaker than the nth heat-rate mode (also normalized by the fundamental in the heat-rate series) by a factor of log(n)/n, where n is the mode number. Predictions of temperature rise and thermal dose were found to be in close agreement with full, finite-difference calculations of the pressure fields, temperature rise, and thermal dose. Applications to non-Gaussian beams were made by fitting the main lobe of the significant modes to Gaussian functions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAUSSIAN beams
KW - TEMPERATURE measurements
KW - GAUSSIAN processes
KW - DISTRIBUTION (Probability theory)
KW - STOCHASTIC processes
N1 - Accession Number: 43211648; Myers, Matthew R. 1 Soneson, Joshua E. 1; Affiliation: 1: Center for Devices and Radiological Health, U. S. Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Jul2009, Vol. 126 Issue 1, p425; Subject Term: GAUSSIAN beams; Subject Term: TEMPERATURE measurements; Subject Term: GAUSSIAN processes; Subject Term: DISTRIBUTION (Probability theory); Subject Term: STOCHASTIC processes; Number of Pages: 9p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1121/1.3148204
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43211648&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - To Eat or Not to Eat? Food Safety in the United States
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2009/07//
VL - 109
IS - 7
M3 - Editorial
SP - 1142
EP - 1142
SN - 00028223
N1 - Accession Number: 42965181; Galson, Steven K. 1; Affiliation: 1: Acting US Surgeon General, US Department of Health and Human Services; Source Info: Jul2009, Vol. 109 Issue 7, p1142; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2009.05.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42965181&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105380378
T1 - To eat or not to eat? Food safety in the United States.
AU - Galson SK
Y1 - 2009/07//
N1 - Accession Number: 105380378. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 7503061.
KW - Food Safety -- United States
KW - Food Contamination -- Analysis
KW - Food Contamination -- Prevention and Control
KW - Food Safety -- Legislation and Jurisprudence
KW - United States
KW - United States Department of Agriculture
KW - United States Environmental Protection Agency
KW - United States Food and Drug Administration
SP - 1142
EP - 1142
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
JA - J AM DIET ASSOC
VL - 109
IS - 7
CY - New York, New York
PB - Elsevier Science
SN - 0002-8223
AD - US Department of Health and Human Services, USA.
U2 - PMID: 19559125.
DO - 10.1016/j.jada.2009.05.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105380378&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ruis, Jerry R.
AU - van Rijckevorsel, Gini G.C.
AU - van den Hoek, Anneke
AU - Koeman, Susan C.
AU - Sonder, Gerard J.B.
T1 - Does Registration of Professionals Improve the Quality of Travelers’ Health Advice?
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
Y1 - 2009/07//Jul/Aug2009
VL - 16
IS - 4
M3 - Article
SP - 263
EP - 266
SN - 11951982
AB - Background. The objectives of the Dutch National Coordination Center for Travelers’ Health Advice (LCR) are to improve the uniformity of travelers’ health advice in the Netherlands and to enhance its quality. The LCR offers national guidelines and quality criteria, as well as a telephone consultation service, where health professionals can pose questions regarding travel medicine. Since 2005, a register for qualified travel health professionals has been in place. We studied the quality and relevance of the telephone consultations, to see whether there was a difference between registered as qualified and nonregistered health professionals. Methods. Telephone questions regarding pretravel advice were logged in September 2007. The questions were categorized as basic or advanced and compared by the profession of the caller, type of institution, and LCR registration of the responsible physician. Results. In 2007, 85% of travel clinic physicians, 42% of general practitioners, and 31% of travel clinic nurses were registered with the LCR. A total of 146 telephone consultations were included in the analysis. Significantly more callers from travel clinics posed advanced questions than those from general practices [odds ratio (OR) 7.6; 95% confidence interval (CI): 3.6–16.1; p= 0.000]. More callers who were registered asked advanced questions, although this difference was not significant (OR 1.7; 95% CI: 0.9–3.3; p= 0.124). Assistants from general practices asked significantly less advanced questions than physicians or nurses. Conclusions. Opening a register for travel health professionals has led to a large increase of professionals who follow courses and register as travel health professionals. A positive association was found between the quality of the questions and the registration of the responsible physician. The quality of travel health advice given in general practices needs increased attention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Travel Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRAVEL -- Health aspects
KW - DISEASES -- Risk factors
KW - PHYSICIANS (General practice)
KW - MEDICAL care
KW - MEDICAL research
KW - NETHERLANDS
N1 - Accession Number: 43394570; Ruis, Jerry R. 1 van Rijckevorsel, Gini G.C. 1,2 van den Hoek, Anneke 2,3 Koeman, Susan C. 1 Sonder, Gerard J.B. 1,2,3; Email Address: gsonder@ggd.amsterdam.nl; Affiliation: 1: LCR, National Coordination Center for Travelers Health Advice, Amsterdam, The Netherlands 2: Department of Infectious Diseases, GGD, Public Health Service Amsterdam, Amsterdam, The Netherlands 3: Academic Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, The Netherlands; Source Info: Jul/Aug2009, Vol. 16 Issue 4, p263; Subject Term: TRAVEL -- Health aspects; Subject Term: DISEASES -- Risk factors; Subject Term: PHYSICIANS (General practice); Subject Term: MEDICAL care; Subject Term: MEDICAL research; Subject Term: NETHERLANDS; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1708-8305.2009.00309.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43394570&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sonder, Gerard
AU - van Rijckevorsel, Gini
AU - van den Hoek, Anneke
T1 - Reply.
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
Y1 - 2009/07//Jul/Aug2009
VL - 16
IS - 4
M3 - Article
SP - 297
EP - 297
SN - 11951982
AB - A response by Gerard Sonder, Gini van Rijckevorsel and Anneke van den Hoek to a letter to the editor about their article on the large discrepancy between the theoretical risk of hepatitis B for travelers is presented.
KW - LETTERS to the editor
KW - HEPATITIS B
N1 - Accession Number: 43394562; Sonder, Gerard 1,2 van Rijckevorsel, Gini 1,2 van den Hoek, Anneke 1,3; Affiliation: 1: Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands 2: LCR, National Coordination Centre for Travellers Health Advice, Amsterdam, The Netherlands 3: Academic Medical Center, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Amsterdam, The Netherlands; Source Info: Jul/Aug2009, Vol. 16 Issue 4, p297; Subject Term: LETTERS to the editor; Subject Term: HEPATITIS B; Number of Pages: 1p; Document Type: Article
L3 - 10.1111/j.1708-8305.2009.00347_2.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43394562&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wimer, Bryan
AU - Dong, Ren G.
AU - Welcome, Daniel E.
AU - Warren, Christopher
AU - McDowell, Thomas W.
T1 - Development of a new dynamometer for measuring grip strength applied on a cylindrical handle
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
Y1 - 2009/07//
VL - 31
IS - 6
M3 - Article
SP - 695
EP - 704
SN - 13504533
AB - Abstract: The objective of this study is to enhance the understanding of the hand grip force applied to a cylindrical handle and to develop a new dynamometer for measuring maximum grip force or grip strength. Specifically, a 40mm instrumented cylindrical handle with six measuring arms was developed. A theoretical model was proposed and used to analyze the principle of the measurement. Human test subjects were used in conducting two sets of experiments to evaluate the handle and to assess the measurement method. This study confirmed that some friction force exists in the grip-only action, but its level is not comparable with the normal force. This study also found that the friction force can stabilize the grip action and marginally increase the grip strength. No reliable correlation between the grip strengths measured with the 40mm cylindrical handle and Jamar handle with a 47.6mm span was observed. This suggests that grip strength measured with Jamar handle may not be reliably applicable to the design and risk assessment of some tools or machines with cylindrical handles. In contrast, the cylindrical handle proved to be able to determine the overall grip strength for a subject, as well as show the grip force distribution around the circumference of the handle. The handle is accurate with less than 4% error, and it demonstrates that the measurement is independent of the loading position along the handle. Therefore, this study concluded that this new dynamometer is suitable for measuring grip strength with sufficient precision. [Copyright &y& Elsevier]
AB - Copyright of Medical Engineering & Physics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GRIP strength
KW - DYNAMOMETER
KW - HANDLES
KW - MUSCLE strength -- Testing
KW - FRICTION
KW - RISK assessment
KW - Dynamometer
KW - Grip force
KW - Grip strength
KW - Hand force
KW - Instrumented handle
N1 - Accession Number: 42966374; Wimer, Bryan 1 Dong, Ren G.; Email Address: RDong@cdc.gov Welcome, Daniel E. 1 Warren, Christopher 1 McDowell, Thomas W. 1; Affiliation: 1: Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, West Virginia 26505, USA; Source Info: Jul2009, Vol. 31 Issue 6, p695; Subject Term: GRIP strength; Subject Term: DYNAMOMETER; Subject Term: HANDLES; Subject Term: MUSCLE strength -- Testing; Subject Term: FRICTION; Subject Term: RISK assessment; Author-Supplied Keyword: Dynamometer; Author-Supplied Keyword: Grip force; Author-Supplied Keyword: Grip strength; Author-Supplied Keyword: Hand force; Author-Supplied Keyword: Instrumented handle; NAICS/Industry Codes: 334519 Other Measuring and Controlling Device Manufacturing; NAICS/Industry Codes: 326199 All Other Plastics Product Manufacturing; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.medengphy.2009.01.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42966374&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meysick, Karen C.
AU - Seidman, Jessica
AU - Falconio, Jason R.
T1 - The Yersinia pseudotuberculosis YplA phospholipase differs in its activity, regulation and secretion from that of the Yersinia enterocolitica YplA
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
Y1 - 2009/07//
VL - 47
IS - 1
M3 - Article
SP - 24
EP - 32
SN - 08824010
AB - Abstract: Analysis of the Yersinia pseudotuberculosis and Yersinia pestis genomes indicates that both species carry an identical copy of a gene that is predicted to encode a protein which shares 80% similarity to the Yersinia enterocolitica YplA, a secreted phospholipase that has been shown to contribute to virulence. In contrast to well tolerated production of the Y. enterocolitica YplA in Escherichia coli, Y. pseudotuberculosis YplA expression was found to be toxic; however, cell viability could be restored if the Y. pseudotuberculosis YplA was expressed in the presence of its accessory protein YplB. In vitro, Y. pseudotuberculosis YplB was shown to reduce the activity of its cognate phospholipase in a dose-dependent manner. To determine whether the Y. pseudotuberculosis and Y. enterocolitica YplAs were secreted and regulated in a similar manner, secretion and promoter activity assays were performed. Unlike the situation apparent in Y. enterocolitica, expression of the Y. pseudotuberculosis yplA gene did not appear to be controlled by the flagellar regulon, nor did the phospholipase appear to be efficiently exported through the flagellar apparatus. These results indicate that the Yersinia YplAs vary in many of their attributes despite their high degree of amino acid homology. [Copyright &y& Elsevier]
AB - Copyright of Microbial Pathogenesis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial genetics
KW - Escherichia coli
KW - Yersinia pseudotuberculosis
KW - Phospholipases
KW - Yersinia enterocolitica
KW - Genomics
KW - Virulence (Microbiology) -- Molecular aspects
KW - Gene expression
KW - Amino acids
KW - Enzymes -- Analysis
KW - Secretion
KW - Accessory protein
KW - Enzyme activity
KW - Expression
KW - Yersinia
N1 - Accession Number: 42100308; Meysick, Karen C. 1; Email Address: karen.meysick@fda.hhs.gov; Seidman, Jessica 2; Falconio, Jason R. 1; Affiliations: 1: Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; 2: Fogarty International Center, NIH, Bethesda, MD 20892, USA; Issue Info: Jul2009, Vol. 47 Issue 1, p24; Thesaurus Term: Bacterial genetics; Thesaurus Term: Escherichia coli; Subject Term: Yersinia pseudotuberculosis; Subject Term: Phospholipases; Subject Term: Yersinia enterocolitica; Subject Term: Genomics; Subject Term: Virulence (Microbiology) -- Molecular aspects; Subject Term: Gene expression; Subject Term: Amino acids; Subject Term: Enzymes -- Analysis; Subject Term: Secretion; Author-Supplied Keyword: Accessory protein; Author-Supplied Keyword: Enzyme activity; Author-Supplied Keyword: Expression; Author-Supplied Keyword: Yersinia; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.micpath.2009.04.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=42100308&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yoon, Somy
AU - Cong, Wei-Tao
AU - Bang, Yeojin
AU - Lee, Sang No
AU - Yoon, Chul Su
AU - Kwack, Seung Jun
AU - Kang, Tae Seok
AU - Lee, Kwang Youl
AU - Choi, Jung-Kap
AU - Choi, Hyun Jin
T1 - Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2009/07//
VL - 30
IS - 4
M3 - Article
SP - 666
EP - 676
SN - 0161813X
AB - Abstract: Mycotoxins are commonly encountered natural products, and are capable of poisoning animals or humans that inhale mold particles from mycotoxin-contaminated foods. Ochratoxin A (OTA) is produced by Aspergillu ochracus and Penicillium verrucosum, and is often found in cereals and agricultural products. Although previous studies have focused on the potent nephrotoxicity and renal carcinogenicity of OTA, more recent studies suggest that it accumulates in the brain and causes oxidative stress and DNA damage in various brain regions and neuronal populations. In the present study, we undertook to investigate the potential harm caused by environmental exposure to OTA in terms of its effects on neuronal cell viability and proteome profiles. OTA was found to significantly reduce the viabilities of human neuroblastoma SH-SY5Y and mouse hippocampal HT22 cells, as assessed by lactic dehydrogenase release into culture media. Generation of reactive oxygen species was detected in OTA-treated SH-SY5Y and HT22 cells, however, caspase activation and increase in p53 phosphorylation were only detected in HT22 cells, and the expressions of several proteins were found to be significantly altered after treating HT22 cells with OTA. Valosin containing protein, prolyl 4-hydroxylase, Atp5b protein, nucleophosmin 1, eukaryotic translation elongation factor 1 delta isoform, ornithine aminotransferase, prohibitin, and peroxiredoxin 6, which have been suggested to be implicated in the pathogenesis of neurodegenerative disorders, were up-regulated. Our findings suggest that coordinated regulations of molecular networks are involved in the OTA-induced cytotoxicity and that proteome response can be an indicative for neurodegeneration. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOTOXICOSES
KW - OCHRATOXINS
KW - APOPTOSIS
KW - CELL death
KW - HIPPOCAMPUS (Brain)
KW - FOOD contamination
KW - NEPHROTOXICOLOGY
KW - CARCINOGENICITY
KW - LACTATE dehydrogenase
KW - PROTEOMICS
KW - OXIDATIVE stress
KW - Cytotoxicity
KW - HT22 cell
KW - Mycotoxin
KW - Ochratoxin A
KW - Proteome response
N1 - Accession Number: 43408183; Yoon, Somy 1 Cong, Wei-Tao 1 Bang, Yeojin 1 Lee, Sang No 1 Yoon, Chul Su 1 Kwack, Seung Jun 2 Kang, Tae Seok 2 Lee, Kwang Youl 1 Choi, Jung-Kap 1 Choi, Hyun Jin 1; Email Address: hjchoi3@chonnam.ac.kr; Affiliation: 1: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea 2: National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, South Korea; Source Info: Jul2009, Vol. 30 Issue 4, p666; Subject Term: MYCOTOXICOSES; Subject Term: OCHRATOXINS; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: HIPPOCAMPUS (Brain); Subject Term: FOOD contamination; Subject Term: NEPHROTOXICOLOGY; Subject Term: CARCINOGENICITY; Subject Term: LACTATE dehydrogenase; Subject Term: PROTEOMICS; Subject Term: OXIDATIVE stress; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: HT22 cell; Author-Supplied Keyword: Mycotoxin; Author-Supplied Keyword: Ochratoxin A; Author-Supplied Keyword: Proteome response; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.neuro.2009.04.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43408183&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Chelonis, John J.
AU - Gravelin, Claire R.
T1 - An examination of the relationship between time estimation and time production
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/07//
VL - 31
IS - 4
M3 - Abstract
SP - 245
EP - 245
SN - 08920362
N1 - Accession Number: 40113783; Chelonis, John J. 1,2 Gravelin, Claire R. 2; Affiliation: 1: National Center for Toxicological Research, Jefferson, AR, USA 2: The College at Brockport, SUNY, Brockport, NY, USA; Source Info: Jul2009, Vol. 31 Issue 4, p245; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2009.04.037
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40113783&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Boctor, Sherin
AU - Wang, Cheng
AU - Ferguson, Sherry
T1 - Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague–Dawley rats
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/07//
VL - 31
IS - 4
M3 - Abstract
SP - 247
EP - 247
SN - 08920362
N1 - Accession Number: 40113792; Boctor, Sherin 1 Wang, Cheng 1,2 Ferguson, Sherry 1,2; Affiliation: 1: Department of Interdisciplinary Biomedical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA 2: Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA; Source Info: Jul2009, Vol. 31 Issue 4, p247; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2009.04.046
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Patterson, Tucker
AU - Li, Mi
AU - Morris, Suzanne
AU - Rodriguez, Jesse
AU - Slikker, William
AU - Mattison, Donald
AU - Paule, Merle
T1 - The effects of chronic methylphenidate treatment on the performance of rhesus monkeys in the NCTR operant test battery
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/07//
VL - 31
IS - 4
M3 - Abstract
SP - 248
EP - 248
SN - 08920362
N1 - Accession Number: 40113795; Patterson, Tucker 1 Li, Mi 1 Morris, Suzanne 2 Rodriguez, Jesse 1 Slikker, William 3 Mattison, Donald 4 Paule, Merle 1; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, USA 2: Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, USA 3: Office of the Director, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, USA 4: National Institute of Child Health and Human Development, Rockville, MD, USA; Source Info: Jul2009, Vol. 31 Issue 4, p248; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2009.04.049
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DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Paule, Merle
T1 - Alteration in nonhuman primate brain function as a consequence of developmental exposure to drugs of abuse
JO - Neurotoxicology & Teratology
JF - Neurotoxicology & Teratology
Y1 - 2009/07//
VL - 31
IS - 4
M3 - Abstract
SP - 251
EP - 251
SN - 08920362
N1 - Accession Number: 40113807; Paule, Merle 1; Affiliation: 1: National Center for Toxicological Research/FDA, Jefferson, AR, USA; Source Info: Jul2009, Vol. 31 Issue 4, p251; Number of Pages: 1p; Document Type: Abstract
L3 - 10.1016/j.ntt.2009.04.061
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mirsaidi, Nasrin
T1 - Looking into problems with transvaginal surgical mesh.
JO - Nursing
JF - Nursing
Y1 - 2009/07//
VL - 39
IS - 7
M3 - Article
SP - 54
EP - 54
SN - 03604039
AB - The article presents an overview of medical complications that have been reported in women who underwent transvaginal repair with synthetic mesh for pelvic organ prolapse or stress urinary incontinence. A discussion of precautions, including acquiring informed consent, that nurses and other medical personnel can take to help prevent complications from synthetic mesh, is presented.
KW - THERAPEUTICS -- Complications
KW - INFORMED consent (Medical law)
KW - URINATION disorders
KW - URINARY incontinence
KW - UTERINE prolapse
KW - UTERUS -- Surgery
KW - MEDICAL supplies
KW - WOMEN -- Diseases -- Treatment
KW - SAFETY measures
N1 - Accession Number: 43096973; Mirsaidi, Nasrin 1; Affiliation: 1: Nurse consultant for general and plastic surgery devices, Center for Devices and Radiological Health; Source Info: Jul2009, Vol. 39 Issue 7, p54; Subject Term: THERAPEUTICS -- Complications; Subject Term: INFORMED consent (Medical law); Subject Term: URINATION disorders; Subject Term: URINARY incontinence; Subject Term: UTERINE prolapse; Subject Term: UTERUS -- Surgery; Subject Term: MEDICAL supplies; Subject Term: WOMEN -- Diseases -- Treatment; Subject Term: SAFETY measures; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105366950
T1 - Device safety. Looking into problems with transvaginal surgical mesh.
AU - Mirsaidi N
Y1 - 2009/07//
N1 - Accession Number: 105366950. Language: English. Entry Date: 20090731. Revision Date: 20150820. Publication Type: Journal Article; case study. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care; Women's Health. NLM UID: 7600137.
KW - Equipment Safety
KW - Pelvic Organ Prolapse -- Surgery
KW - Postoperative Complications
KW - Stress Incontinence -- Surgery
KW - Surgical Mesh -- Adverse Effects
KW - Aged
KW - Female
KW - Inpatients
KW - Patient Education
KW - Perioperative Nursing
KW - Surgical Patients
KW - Vagina -- Injuries
SP - 54
EP - 54
JO - Nursing
JF - Nursing
JA - NURSING
VL - 39
IS - 7
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Nurse consultant, general and plastic surgery devices, Center for Devices and Radiological Health
U2 - PMID: 19543044.
DO - 10.1097/01.NURSE.0000357272.48538.4b
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Betz, Joseph M.
AU - Anderson, Linda
AU - Avigan, Mark I.
AU - Barnes, Joanne
AU - Farnsworth, Norman R.
AU - Gerdén, Barbro
AU - Henderson, Leigh
AU - Kennelly, EdwardJ.
AU - Koetter, Uwe
AU - Lessard, Stephanie
AU - Dog, Tieraona Low
AU - McLaughlin, Michelle
AU - Naser, Belal
AU - W.^Osmers, Ruediger G.
AU - Pellicore, Linda S.
AU - Senior, John R.
AU - van Breemen, Richard B.
AU - Wuttke, Wolfgang
AU - Cardellina II, John H.
T1 - Black Cohosh.
JO - Nutrition Today
JF - Nutrition Today
Y1 - 2009/07//Jul/Aug2009
VL - 44
IS - 4
M3 - Article
SP - 155
EP - 162
SN - 0029666X
AB - The article discusses the therapeutic uses of black cohosh. It outlines the growing popularity of the botanical species in alleviating menopausal symptoms, and relates the expansion of its research on chemistry, pharmacology and clinical efficacy. However, together with the species growing demand, issues concerning its implications of liver damage had appeared which prompted the Office of Dietary Supplements or National Institute of Health (NIH) convened a workshop to determine its uses.
KW - BUGBANE
KW - MENOPAUSE -- Treatment
KW - MENOPAUSE
KW - LIVER diseases
KW - CLINICAL trials
KW - PHARMACEUTICAL research
KW - THERAPEUTIC use
KW - UNITED States. Office of Dietary Supplements
KW - ALTERNATIVE treatment
KW - UNITED States
N1 - Accession Number: 44046023; Betz, Joseph M. 1; Email Address: BetzJ@od.nih.gov Anderson, Linda 2 Avigan, Mark I. 3 Barnes, Joanne 4 Farnsworth, Norman R. 5 Gerdén, Barbro 6 Henderson, Leigh 7 Kennelly, EdwardJ. 8,9 Koetter, Uwe 10,11 Lessard, Stephanie 12 Dog, Tieraona Low 13 McLaughlin, Michelle 14 Naser, Belal 15 W.^Osmers, Ruediger G. 16 Pellicore, Linda S. 17,18 Senior, John R. 19 van Breemen, Richard B. 20 Wuttke, Wolfgang 21 Cardellina II, John H. 22; Affiliation: 1: Director of Analytical Methods and Reference Materials Program, Office of Dietary Supplements, National Institutes of Health 2: Principal Pharmaceutical Assessor in the Licensing Division of the Medicines and Healthcare Products Regulatory Agency, United Kingdom 3: Director of the Division of Drug Risk Evaluation in the Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration 4: Associate Professor in Herbal Medicines in the School of Pharmacy, Faculty of Medical and Health Sciences at the University of Auckland, New Zealand 5: Distinguished University Professor and Research Professor of Pharmacognosy, University of Illinois, Chicago College of Pharmacy 6: Medical Products Agency, Sweden 7: Senior Scientific Assessor in the Medicines and Healthcare Products Regulatory Agency, United Kingdom 8: Associate Professor of Biological Sciences, Lehman College, City University of New York 9: Executive Officer of the PhD Program in Biochemistry, Graduate Center, City University of New York 10: Chief Development Officer, Max Zeller Sohne AG, Switzerland 11: Head of Research & Development, Max Zeller Sohne AG, Switzerland 12: Head of the Health Risk Assessment Unit, Bureau of Clinical Trials and Health Science, Natural Health Products Directorate, Health Canada 13: Director of Education in the Program of Integrative Medicine, University of Arizona, Tucson 14: Head of the Pie-Market Assessment Section of the Office of Complementary Medicines, Therapeutic Goods Administration, Australia 15: Head of Drug Safety and Pharmacovigilance at Schaper & Brümmer GmbH & Co. KG, in Germany 16: Department of Obstetrics and Gynecology, Hildesheim General Hospital in Germany 17: Supervisory Senior Toxicologist in the Division of Dietary Supplements, US Food and Drug Administration 18: Senior Toxicologist in the Division of Dermatology and Dental Products, Center for Drug Evaluation and Research, US Food and Drug Administration 19: Associate Director for Science in the Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration 20: Professor of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago College of Pharmacy 21: Professor of Endocrinology, University of Gottingen in Germany 22: Health Sciences Administrator, Office of Dietary Supplements, National Institutes of Health; Source Info: Jul/Aug2009, Vol. 44 Issue 4, p155; Subject Term: BUGBANE; Subject Term: MENOPAUSE -- Treatment; Subject Term: MENOPAUSE; Subject Term: LIVER diseases; Subject Term: CLINICAL trials; Subject Term: PHARMACEUTICAL research; Subject Term: THERAPEUTIC use; Subject Term: UNITED States. Office of Dietary Supplements; Subject Term: ALTERNATIVE treatment; Subject Term: UNITED States; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 8p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105403608
T1 - Don't become a statistic: work safely at heights.
AU - Mulhern B
AU - Lentz TJ
Y1 - 2009/07//
N1 - Accession Number: 105403608. Language: English. Entry Date: 20091002. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Consumer Health; USA. Special Interest: Consumer Health. NLM UID: 7610574.
KW - Accidental Falls -- Prevention and Control
KW - Accidents, Occupational -- Prevention and Control
KW - Altitude
KW - Safety
KW - Communication Barriers
KW - Hispanics -- Statistics and Numerical Data
KW - Risk Factors
KW - United States Occupational Safety and Health Administration
KW - United States
SP - 36
EP - 40
JO - Occupational Health & Safety
JF - Occupational Health & Safety
JA - OCCUP HEALTH SAF
VL - 77
IS - 8
CY - Chatsworth, California
PB - 1105 Media, Inc.
SN - 0362-4064
AD - National Institute for Occupational Safety and Health, USA.
U2 - PMID: 19663347.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105438481
T1 - Romiplostim for the treatment of chronic immune (idiopathic) thrombocytopenic purpura.
AU - Jamali F
AU - Lemery S
AU - Ayalew K
AU - Robottom S
AU - Robie-Suh K
AU - Rieves D
AU - Pazdur R
Y1 - 2009/07//
N1 - Accession Number: 105438481. Language: English. Entry Date: 20091002. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Commentary: Andrews EB, Kaye JA, van Bennekom C. The Jamali/Lemery/Ayalew et al article reviewed. The REMS publication paradox. (ONCOLOGY (08909091)) Jul2009; 23 (8): 715-717; Lyman GH. The Jamali/Lemery/Ayalew et al article reviewed. The road to romiplostim approval and beyond. (ONCOLOGY (08909091)) Jul2009; 23 (8): 709-715. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 8712059.
KW - Carrier Proteins -- Administration and Dosage
KW - Purpura, Thrombocytopenic -- Drug Therapy
KW - Recombinant Proteins -- Therapeutic Use
KW - Chronic Disease
KW - Clinical Trials
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Myelodysplastic Syndromes -- Drug Therapy
KW - Receptors, Cell Surface -- Drug Effects
KW - Treatment Outcomes
SP - 704
EP - 709
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 23
IS - 8
CY - Norwalk, Connecticut
PB - UBM Medica
AB - PURPOSE: On August 22, 2008, Romiplostim (Nplate for Injection) received approval from the US Food and Drug Administration (FDA) for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. This report summarizes the FDA analyses of the clinical data supporting this approval. EXPERIMENTAL DESIGN: The FDA reviewed data from two double-blind, placebo-controlled clinical studies, an uncontrolled extension study, and supportive studies. In the controlled studies, enrolled patients had completed at least one prior treatment for chronic ITP and had a platelet count < or = 30 x 10(9)/L. One study enrolled patients who had undergone splenectomy; the other enrolled patients who had not undergone splenectomy. The primary endpoint in both controlled studies was durable platelet response. RESULTS: Overall, 125 patients were randomized in the controlled studies. A durable platelet response was observed in 61% of nonsplenectomized patients and 38% of patients who had undergone splenectomy. One placebo group patient achieved a durable platelet response. Serious hemorrhage events were reported in 10% of placebo recipients and 6% of romiplostim recipients. In the extension study, patients received romiplostim for a median of 60 weeks and a maximum of 96 weeks; the majority of patients maintained platelet counts > or = 50 x 10(9)/L throughout the study. Major safety findings pertained to a risk for bone marrow reticulin formation and worsened thrombocytopenia following romiplostim discontinuation. CONCLUSIONS: The FDA approved romiplostim for use among certain patients with chronic ITP. This approval included a Risk Evaluation and Mitigation Strategy to ensure that the benefits of the drug outweigh its risks.
SN - 0890-9091
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 19711585.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dworkin, Robert H.
AU - Turk, Dennis C.
AU - Revicki, Dennis A.
AU - Harding, Gale
AU - Coyne, Karin S.
AU - Peirce-Sandner, Sarah
AU - Bhagwat, Dileep
AU - Everton, Dennis
AU - Burke, Laurie B.
AU - Cowan, Penney
AU - Farrar, John T.
AU - Hertz, Sharon
AU - Max, Mitchell B.
AU - Rappaport, Bob A.
AU - Melzack, Ronald
T1 - Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2)
JO - Pain (03043959)
JF - Pain (03043959)
Y1 - 2009/07//
VL - 144
IS - 1/2
M3 - Article
SP - 35
EP - 42
SN - 03043959
AB - Abstract: The objective of the present research was to develop a single measure of the major symptoms of both neuropathic and non-neuropathic pain that can be used in studies of epidemiology, natural history, pathophysiologic mechanisms, and treatment response. We expanded and revised the Short-form McGill Pain Questionnaire [1] Copyright: SF-MPQ, R. Melzack; SF-MPQ-2, R. Melzack and the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). 1 (SF-MPQ) pain descriptors by adding symptoms relevant to neuropathic pain and by modifying the response format to a 0–10 numerical rating scale to provide increased responsiveness in longitudinal studies and clinical trials. The reliability, validity, and subscale structure of the revised SF-MPQ (SF-MPQ-2 1 ) were examined in responses from 882 individuals with diverse chronic pain syndromes and in 226 patients with painful diabetic peripheral neuropathy who participated in a randomized clinical trial. The data suggest that the SF-MPQ-2 has excellent reliability and validity, and the results of both exploratory and confirmatory factor analyses provided support for four readily interpretable subscales—continuous pain, intermittent pain, predominantly neuropathic pain, and affective descriptors. These results provide a basis for use of the SF-MPQ-2 in future clinical research, including clinical trials of treatments for neuropathic and non-neuropathic pain conditions. [Copyright &y& Elsevier]
AB - Copyright of Pain (03043959) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MCGILL Pain Questionnaire
KW - PAIN
KW - NEUROPATHY
KW - PSYCHIATRIC rating scales
KW - OUTCOME assessment (Medical care)
KW - CLINICAL trials
KW - Assessment
KW - Neuropathic pain
KW - Non-neuropathic pain
KW - Outcome measures
KW - Pain
KW - Pain quality
KW - Painful diabetic peripheral neuropathy
KW - Short-form McGill Pain Questionnaire
N1 - Accession Number: 40636554; Dworkin, Robert H. 1; Email Address: robert_dworkin@urmc.rochester.edu Turk, Dennis C. 2 Revicki, Dennis A. 3 Harding, Gale 3 Coyne, Karin S. 3 Peirce-Sandner, Sarah 4 Bhagwat, Dileep 5 Everton, Dennis 5 Burke, Laurie B. 6 Cowan, Penney 7 Farrar, John T. 8 Hertz, Sharon 6 Max, Mitchell B. 9 Rappaport, Bob A. 6 Melzack, Ronald 10; Affiliation: 1: Departments of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY 14642, USA 2: Department of Anesthesiology, University of Washington, Seattle, WA, USA 3: United Biosource Corporation, Bethesda, MD, USA 4: Department of Anesthesiology, University of Rochester, Rochester, NY, USA 5: EpiCept Corporation, Tarrytown, NY, USA 6: United States Food and Drug Administration, Bethesda, MD, USA 7: American Chronic Pain Association, Rocklin, CA, USA 8: Department of Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA 9: Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA 10: Department of Psychology, McGill University, Montreal, Canada; Source Info: Jul2009, Vol. 144 Issue 1/2, p35; Subject Term: MCGILL Pain Questionnaire; Subject Term: PAIN; Subject Term: NEUROPATHY; Subject Term: PSYCHIATRIC rating scales; Subject Term: OUTCOME assessment (Medical care); Subject Term: CLINICAL trials; Author-Supplied Keyword: Assessment; Author-Supplied Keyword: Neuropathic pain; Author-Supplied Keyword: Non-neuropathic pain; Author-Supplied Keyword: Outcome measures; Author-Supplied Keyword: Pain; Author-Supplied Keyword: Pain quality; Author-Supplied Keyword: Painful diabetic peripheral neuropathy; Author-Supplied Keyword: Short-form McGill Pain Questionnaire; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.pain.2009.04.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xu, Houming
AU - Wang, Yue
AU - Liu, Naifeng
T1 - A hospital-based survey of healthcare professionals in the awareness of pharmacovigilance.
JO - Pharmacoepidemiology & Drug Safety
JF - Pharmacoepidemiology & Drug Safety
Y1 - 2009/07//
VL - 18
IS - 7
M3 - Article
SP - 624
EP - 630
SN - 10538569
AB - Purpose This study was designed to investigate the awareness of pharmacovigilance by healthcare professionals in Jiangsu, China. Methods This study was carried out in 62 hospitals in Jiangsu province, China, between May and August, 2007, using a closed and choice questionnaire. The data were entered using the EpiData3.1 software and analyzed by χ2-test, single-factor analysis, and multi-factor logistic regression using the SAS9.1 software. Result A total of 2361 questionnaires were suitable in completeness for the statistical analyses. The participants were found to have a good recognition of basic adverse drug reaction (ADR) knowledge, administration knowledge, and drug use rationale, but poor awareness of pharmacovigilance. Significant differences existed in the awareness of pharmacovigilance across regions, hospital classes, and professions. Single-factor analyses showed that region, hospital class, profession, department type, and length of service in the current position, education level, and professional title all significantly affected the degree of awareness. More stringent multi-factor analyses showed that the degree of awareness was highly related to region, hospital class, profession, education level, and professional title. Conclusion The study participants had better basic ADR knowledge than pharmacovigilance knowledge. The study suggests that it is imperative to provide special training to healthcare professionals from different regions and different departments in order to improve the awareness of pharmacovigilance and the development of ADR monitoring. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacoepidemiology & Drug Safety is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 64707169; Xu, Houming 1,2; Wang, Yue 3; Liu, Naifeng 4; Affiliations: 1: China Pharmaceutical University, Nanjing, P.R China; 2: ADR Monitoring Center of Jiangsu Province, Nanjing, P.R China; 3: Jiangsu Food and drug administration, Nanjing, P.R China; 4: Zhongda Hospital Affiliated to Southeast University, Nanjing, P.R China; Issue Info: Jul2009, Vol. 18 Issue 7, p624; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/pds.1752
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Zhou, Hongbo
AU - Yu, Zhengjun
AU - Hu, Yong
AU - Tu, Jiagang
AU - Zou, Wei
AU - Peng, Yaping
AU - Zhu, Jiping
AU - Li, Yongtao
AU - Zhang, Anding
AU - Yu, Ziniu
AU - Ye, Zhiping
AU - Chen, Huanchun
AU - Jin, Meilin
T1 - The Special Neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/07//
VL - 4
IS - 7
M3 - Article
SP - 1
EP - 8
PB - Public Library of Science
SN - 19326203
AB - The variation of highly pathogenic avian influenza H5N1 virus results in gradually increased virulence in poultry, and human cases continue to accumulate. The neuraminidase (NA) stalk region of influenza virus varies considerably and may associate with its virulence. The NA stalk region of all N1 subtype influenza A viruses can be divided into six different stalk-motifs, H5N1/2004-like (NA-wt), WSN-like, H5N1/97-like, PR/8-like, H7N1/99-like and H5N1/96-like. The NA-wt is a special NA stalk-motif which was first observed in H5N1 influenza virus in 2000, with a 20-amino acid deletion in the 49th to 68th positions of the stalk region. Here we show that there is a gradual increase of the special NA stalk-motif in H5N1 isolates from 2000 to 2007, and notably, the special stalk-motif is observed in all 173 H5N1 human isolates from 2004 to 2007. The recombinant H5N1 virus with the special stalk-motif possesses the highest virulence and pathogenicity in chicken and mice, while the recombinant viruses with the other stalk-motifs display attenuated phenotype. This indicates that the special stalk-motif has contributed to the high virulence and pathogenicity of H5N1 isolates since 2000. The gradually increasing emergence of the special NA stalk-motif in H5N1 isolates, especially in human isolates, deserves attention by all. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAMINIDASE
KW - RESPIRATORY infections
KW - INFLUENZA
KW - MICROORGANISMS
KW - ORTHOMYXOVIRUSES
KW - INFLUENZA viruses
KW - AMINO acids
KW - AVIAN influenza
KW - ORGANIC acids
N1 - Accession Number: 58518922; Zhou, Hongbo 1 Yu, Zhengjun 1 Hu, Yong 1 Tu, Jiagang 1 Zou, Wei 1 Peng, Yaping 1 Zhu, Jiping 1 Li, Yongtao 1 Zhang, Anding 1 Yu, Ziniu 1 Ye, Zhiping 2 Chen, Huanchun 1; Email Address: chenhch@mail.hzau.edu.cn Jin, Meilin 1; Email Address: jinmeilin@mail.hzau.edu.cn; Affiliation: 1: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, the People's Republic of China. 2: Laboratory of Pediatric and Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America.; Source Info: 2009, Vol. 4 Issue 7, p1; Subject Term: NEURAMINIDASE; Subject Term: RESPIRATORY infections; Subject Term: INFLUENZA; Subject Term: MICROORGANISMS; Subject Term: ORTHOMYXOVIRUSES; Subject Term: INFLUENZA viruses; Subject Term: AMINO acids; Subject Term: AVIAN influenza; Subject Term: ORGANIC acids; Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0006277
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reed, Laurence D.
T1 - A Message from the Editor.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009/07//Jul/Aug2009
VL - 124
IS - 4
M3 - Article
SP - 477
EP - 477
SN - 00333549
AB - The article discusses various reports within the issue including the cigarette pricing, the mortality rates associated to the economic benefits of coal mining and the efficacy of education interventions in postpartum smoking relapse among pregnant women.
KW - CIGARETTES -- Marketing
KW - COAL mines & mining
N1 - Accession Number: 42526673; Reed, Laurence D. 1; Affiliation: 1: Captain, U.S. Public Health Service; Source Info: Jul/Aug2009, Vol. 124 Issue 4, p477; Subject Term: CIGARETTES -- Marketing; Subject Term: COAL mines & mining; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; NAICS/Industry Codes: 312220 Tobacco product manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kwon, J.H.
AU - Lee, J.
AU - Waje, C.
AU - Ahn, J.J.
AU - Kim, G.R.
AU - Chung, H.W.
AU - Kim, D.H.
AU - Lee, J.W.
AU - Byun, M.W.
AU - Kim, K.S.
AU - Park, S.H.
AU - Lee, E.J.
AU - Ahn, D.U.
T1 - The quality of irradiated red ginseng powder following transport from Korea to the United States
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2009/07//
VL - 78
IS - 7/8
M3 - Article
SP - 643
EP - 646
SN - 0969806X
AB - Abstract: Irradiated red ginseng powder (2.4kg) in commercial bottles was transported from Korea to Iowa State University (USA) via air- (10 days) and sea-cargos (50 days) to prove its qualities and identity. The microbial loads of transported samples by both methods after 5kGy irradiation were reduced from 106 to 103 CFU/g in total aerobic bacteria and from 20CFU/g (minimum detection level) to negative in coliforms, respectively, which are in accordance with Korean microbial standard for ginseng powders. Sea-transported irradiated samples showed the increased thiobarbituric acid reactive substances (TBARS) and Hunter''s a (red) value, but sensory qualities of all the red ginseng samples were not significantly different depending on irradiation and transportation means. Irradiated samples could be identified from the non-irradiated ones by the analysis of photostimulated luminescence, thermoluminescence, and electron spin resonance. This trial proved the feasibility of inter-country transportation of irradiated red ginseng powder. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GINSENG
KW - FOOD -- Transportation
KW - IRRADIATION
KW - FOOD -- Quality
KW - AEROBIC bacteria
KW - COLIFORMS
KW - FOOD -- Sensory evaluation
KW - KOREA
KW - UNITED States
KW - Identification
KW - Irradiation
KW - Quality
KW - Red ginseng powder
KW - Transportation
N1 - Accession Number: 42104050; Kwon, J.H. 1; Email Address: jhkwon@knu.ac.kr Lee, J. 1 Waje, C. 1 Ahn, J.J. 1 Kim, G.R. 1 Chung, H.W. 2 Kim, D.H. 3 Lee, J.W. 3 Byun, M.W. 3 Kim, K.S. 4,5 Park, S.H. 5 Lee, E.J. 6 Ahn, D.U. 6; Affiliation: 1: Department of Food Science and Technology, Kyungpook National University, Daegu 702-701, Korea 2: Korea Food and Drug Administration, Seoul 122-704, Korea 3: Advanced Radiation Technology Institute, Jeongeup, Jeonbuk 580-185, Korea 4: Department of Food Science and Nutrition, Chosun University, Gwangju 501-759, Korea 5: Greenpia Tech Inc., Yeoju, Gyeonggi-do 469-810, Korea 6: Department of Animal Science, Iowa State University, Ames, IA 50010-3150, USA; Source Info: Jul2009, Vol. 78 Issue 7/8, p643; Subject Term: GINSENG; Subject Term: FOOD -- Transportation; Subject Term: IRRADIATION; Subject Term: FOOD -- Quality; Subject Term: AEROBIC bacteria; Subject Term: COLIFORMS; Subject Term: FOOD -- Sensory evaluation; Subject Term: KOREA; Subject Term: UNITED States; Author-Supplied Keyword: Identification; Author-Supplied Keyword: Irradiation; Author-Supplied Keyword: Quality; Author-Supplied Keyword: Red ginseng powder; Author-Supplied Keyword: Transportation; NAICS/Industry Codes: 484230 Specialized Freight (except Used Goods) Trucking, Long-Distance; NAICS/Industry Codes: 484220 Specialized Freight (except Used Goods) Trucking, Local; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.radphyschem.2009.03.055
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42104050&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shim, Sung-Lye
AU - Hwang, In-Min
AU - Ryu, Keun-Young
AU - Jung, Min-Seok
AU - Seo, Hye-young
AU - Kim, Hee-Yeon
AU - Song, Hyun-Pa
AU - Kim, Jae-Hun
AU - Lee, Ju-Woon
AU - Byun, Myung-Woo
AU - Kwon, Joong-Ho
AU - Kim, Kyong-Su
T1 - Effect of γ-irradiation on the volatile compounds of medicinal herb, Paeoniae Radix
JO - Radiation Physics & Chemistry
JF - Radiation Physics & Chemistry
Y1 - 2009/07//
VL - 78
IS - 7/8
M3 - Article
SP - 665
EP - 669
SN - 0969806X
AB - Abstract: A study was carried out to find the effect of γ-irradiation on contents of volatile compounds from medicinal herb, Paeoniae Radix (Paenia albiflora Pallas var. trichocarpa Bunge). The volatile compounds of control, 1, 3, 5 and 10kGy irradiated samples were extracted by simultaneous steam distillation and extraction (SDE) method and analyzed by gas chromatograph-mass spectrometer. The major volatile compounds were paeonol, (E)-carveol, (E,E)-2,4-octadienal, methyl salicylate, myrtanol and eugenol acetate. Volatile compounds belonging to chemical classes of acids, alcohols, aldehydes, esters, hydrocarbons and miscellaneous were identified in all experimental samples. The types of volatile compounds in irradiated samples were similar to those of non-irradiated sample and the concentrations of these compounds differed between treatments. 1,3-Bis (1,1-dimethylethyl)-benzene was identified by using the selected ion monitoring (GC/MS-SIM) mode. The concentration of this compound increased with the increase of irradiation dose level. These results suggest that it could be used as the base data for the effect of γ-irradiation on medicinal herb. [Copyright &y& Elsevier]
AB - Copyright of Radiation Physics & Chemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - GAMMA rays
KW - VOLATILE organic compounds
KW - HERBAL medicine
KW - DISTILLATION
KW - EXTRACTION techniques
KW - GAS chromatography
KW - MASS spectrometers
KW - RADIATION -- Dosage
KW - γ-irradiation
KW - Medicinal herb
KW - Paeoniae Radix
KW - Volatile compound
N1 - Accession Number: 42104055; Shim, Sung-Lye 1 Hwang, In-Min 1 Ryu, Keun-Young 1 Jung, Min-Seok 1 Seo, Hye-young 2 Kim, Hee-Yeon 3 Song, Hyun-Pa 4 Kim, Jae-Hun 4 Lee, Ju-Woon 4 Byun, Myung-Woo 4 Kwon, Joong-Ho 5 Kim, Kyong-Su 2; Email Address: kskim@chosun.ac.kr; Affiliation: 1: Department of Food and Nutrition, Chosun University, Republic of Korea 2: Korea Food Research Institute, Republic of Korea 3: Korea Food and Drug Administration, Republic of Korea 4: Advanced Radiation Technology Institute, KAERI, Jeongeup 580-185, Republic of Korea 5: Department of Food Science and Technology, Kyungpook National University, Republic of Korea; Source Info: Jul2009, Vol. 78 Issue 7/8, p665; Subject Term: GAMMA rays; Subject Term: VOLATILE organic compounds; Subject Term: HERBAL medicine; Subject Term: DISTILLATION; Subject Term: EXTRACTION techniques; Subject Term: GAS chromatography; Subject Term: MASS spectrometers; Subject Term: RADIATION -- Dosage; Author-Supplied Keyword: γ-irradiation; Author-Supplied Keyword: Medicinal herb; Author-Supplied Keyword: Paeoniae Radix; Author-Supplied Keyword: Volatile compound; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.radphyschem.2009.03.075
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42104055&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tekin, Erdal
AU - Mocan, Naci
AU - Liang, Lan
AD - GA State U
AD - LA State U
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD
T1 - Do Adolescents with Emotional or Behavioral Problems Respond to Cigarette Prices?
JO - Southern Economic Journal
JF - Southern Economic Journal
Y1 - 2009/07//
VL - 76
IS - 1
SP - 67
EP - 85
SN - 00384038
N1 - Accession Number: 1055129; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200908
N2 - Adolescents with mental health problems have much higher rates of smoking than those without such problems. Although a large body of evidence suggests that higher cigarette prices reduce smoking prevalence and the quantity smoked, little is known about the interaction between mental health or behavioral problems and tobacco consumption in the general population or among adolescents. Using a national representative sample of adolescents from the National Longitudinal Study of Adolescent Health and employing validated psychiatric measures of emotional distress and behavioral problems, we estimate the price elasticity of cigarette demand for adolescents who have behavioral or emotional problems. The results indicate that these adolescents are at least as responsive to cigarette prices as adolescents with no emotional or behavioral problems.
KW - Consumer Economics: Empirical Analysis D12
KW - Fertility; Family Planning; Child Care; Children; Youth J13
KW - Food; Beverages; Cosmetics; Tobacco; Wine and Spirits L66
L3 - http://journal.southerneconomic.org/loi/soec
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1055129&site=ehost-live&scope=site
UR - http://journal.southerneconomic.org/loi/soec
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Kannan, Meganathan
AU - Mohan, Ketha V. Krishna
AU - Kulkarni, Sandhya
AU - Atreya, Chintamani
T1 - Membrane array–based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis.
JO - Transfusion
JF - Transfusion
Y1 - 2009/07//Jul2009 Part 1 of 2
VL - 49
IS - 7
M3 - Article
SP - 1443
EP - 1450
PB - Wiley-Blackwell
SN - 00411132
AB - BACKGROUND: Enucleated platelets (PLTs) utilize posttranscriptional gene (mRNA) regulation (PTGR) for their normal morphologic and physiologic functions, which are altered in their ex vivo storage, also collectively referred to as storage lesions. While cellular micro-RNAs (miRNAs) play a significant role in posttranscriptional gene (mRNA) regulation by binding to their target mRNAs, comprehensive analysis of apoptosis-associated miRNAs and global changes in their profiles during PLT storage have not been evaluated to date. STUDY DESIGN AND METHODS: In this report room temperature–stored PLTs of Days 0, 2, and 9 were analyzed by differential profiling for 52 apoptosis-associated human miRNAs. After total RNA extraction from the samples, a membrane array–based miRNA analysis was carried out. Prediction of target genes was performed by bioinformatics-based approaches. RESULTS: Our analysis revealed that during storage, Let-7a, -7c, -7e, -7f, -7g, and -7i miRNA profiles of the PLTs were barely detectable, while levels of miR-150, -151, -152, -184, -188, -196a, -197, and -202 remained at high levels in PLTs. The rest of the miRNA levels were in between. However, two miRNAs, Let-7b and miR-16, distinctly demonstrated an increasing trend while miR-7 and miR-145 showed a decreasing profile during PLT storage. For these four miRNAs, we also identified their potential target mRNAs. CONCLUSIONS: Overall, these results confirm the fact that miRNAs do exist in PLTs, and among 52 apoptosis-specific miRNAs studied, only a few selected miRNAs did perturb during PLT storage. Future experimental evaluation of these miRNA–target mRNA interactions will provide new insights into the molecular mechanisms of PLT storage–associated lesions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - BLOOD platelets
KW - MESSENGER RNA
KW - BIOINFORMATICS
KW - COMPUTERS in medicine
N1 - Accession Number: 42875251; Kannan, Meganathan 1 Mohan, Ketha V. Krishna 1 Kulkarni, Sandhya 1 Atreya, Chintamani 1; Email Address: chintamani.atreya@fda.hhs.gov; Affiliation: 1: Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland.; Source Info: Jul2009 Part 1 of 2, Vol. 49 Issue 7, p1443; Subject Term: APOPTOSIS; Subject Term: BLOOD platelets; Subject Term: MESSENGER RNA; Subject Term: BIOINFORMATICS; Subject Term: COMPUTERS in medicine; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1537-2995.2009.02140.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42875251&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kannan, Meganathan
AU - Mohan, Ketha V. Krishna
AU - Kulkarni, Sandhya
AU - Atreya, Chintamani
T1 - Membrane array–based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis.
JO - Transfusion
JF - Transfusion
Y1 - 2009/07//Jul2009 Part 1 of 2
VL - 49
IS - 7
M3 - Article
SP - 1443
EP - 1450
SN - 00411132
AB - BACKGROUND: Enucleated platelets (PLTs) utilize posttranscriptional gene (mRNA) regulation (PTGR) for their normal morphologic and physiologic functions, which are altered in their ex vivo storage, also collectively referred to as storage lesions. While cellular micro-RNAs (miRNAs) play a significant role in posttranscriptional gene (mRNA) regulation by binding to their target mRNAs, comprehensive analysis of apoptosis-associated miRNAs and global changes in their profiles during PLT storage have not been evaluated to date. STUDY DESIGN AND METHODS: In this report room temperature–stored PLTs of Days 0, 2, and 9 were analyzed by differential profiling for 52 apoptosis-associated human miRNAs. After total RNA extraction from the samples, a membrane array–based miRNA analysis was carried out. Prediction of target genes was performed by bioinformatics-based approaches. RESULTS: Our analysis revealed that during storage, Let-7a, -7c, -7e, -7f, -7g, and -7i miRNA profiles of the PLTs were barely detectable, while levels of miR-150, -151, -152, -184, -188, -196a, -197, and -202 remained at high levels in PLTs. The rest of the miRNA levels were in between. However, two miRNAs, Let-7b and miR-16, distinctly demonstrated an increasing trend while miR-7 and miR-145 showed a decreasing profile during PLT storage. For these four miRNAs, we also identified their potential target mRNAs. CONCLUSIONS: Overall, these results confirm the fact that miRNAs do exist in PLTs, and among 52 apoptosis-specific miRNAs studied, only a few selected miRNAs did perturb during PLT storage. Future experimental evaluation of these miRNA–target mRNA interactions will provide new insights into the molecular mechanisms of PLT storage–associated lesions. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - BLOOD platelets
KW - MESSENGER RNA
KW - BIOINFORMATICS
KW - COMPUTERS in medicine
N1 - Accession Number: 42875251; Kannan, Meganathan 1; Mohan, Ketha V. Krishna 1; Kulkarni, Sandhya 1; Atreya, Chintamani 1; Email Address: chintamani.atreya@fda.hhs.gov; Source Information: Jul2009 Part 1 of 2, Vol. 49 Issue 7, p1443; Subject: APOPTOSIS; Subject: BLOOD platelets; Subject: MESSENGER RNA; Subject: BIOINFORMATICS; Subject: COMPUTERS in medicine; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1537-2995.2009.02140.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=42875251&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105384252
T1 - Membrane array-based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis.
AU - Kannan M
AU - Mohan KV
AU - Kulkarni S
AU - Atreya C
Y1 - 2009/07//Jul2009 Part 1 of 2
N1 - Accession Number: 105384252. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: Jul2009 Part 1 of 2. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Blood Platelets -- Metabolism
KW - Blood Preservation
KW - Genetic Techniques -- Methods
KW - RNA
KW - Apoptosis
KW - Bioinformatics
KW - Software
KW - Temperature
SP - 1443
EP - 1450
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 7
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration/PHS, Bethesda, Maryland.
U2 - PMID: 19389023.
DO - 10.1111/j.1537-2995.2009.02140.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105384252&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Seto, Jason
AU - Walsh, Michael P.
AU - Mahadevan, Padmanabhan
AU - Purkayastha, Anjan
AU - Clark, James M.
AU - Tibbetts, Clark
AU - Seto, Donald
T1 - Genomic and bioinformatics analyses of HAdV-14p, reference strain of a re-emerging respiratory pathogen and analysis of B1/B2
JO - Virus Research
JF - Virus Research
Y1 - 2009/07//
VL - 143
IS - 1
M3 - Article
SP - 94
EP - 105
SN - 01681702
AB - Abstract: Unlike other human adenovirus (HAdV) species, B is divided into subspecies B1 and B2. Originally this was partly based on restriction enzyme (RE) analysis. B1 members, except HAdV-50, are commonly associated with respiratory diseases while B2 members are rarely associated with reported respiratory diseases. Recently two members of B2 have been identified in outbreaks of acute respiratory disease (ARD). One, HAdV-14, has re-emerged after an apparent 52-year absence. Genomic analysis and bioinformatics data are reported for HAdV-14 prototype for use as a reference and to understand and counter its re-emergence. The data complement and extend the original criteria for subspecies designation, unique amongst the adenoviruses, and highlight differences between B1 and B2, representing the first comprehensive analysis of this division. These data also provide finer granularity into the pathoepidemiology of the HAdVs. Whole genome analysis uncovers heterogeneous identity structures of the hexon and fiber genes amongst the HAdV-14 and the B1/B2 subspecies, which may be important in prescient vaccine development. Analysis of cell surface proteins provides insight into HAdV-14 tropism, accounting for its role as a respiratory pathogen. This HAdV-14 prototype genome is also a reference for applications of B2 adenoviruses as vectors for vaccine development and gene therapy. [Copyright &y& Elsevier]
AB - Copyright of Virus Research is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - MICROBIAL genomics
KW - BIOINFORMATICS
KW - EMERGING infectious diseases
KW - RESPIRATORY diseases
KW - VIRUS-induced enzymes
KW - VIRUSES -- Identification
KW - B1, B2 subspecies
KW - Human adenovirus
KW - Human therapy vector
KW - Re-emerging pathogen
KW - Respiratory disease
KW - Viral bioinformatics
N1 - Accession Number: 40112070; Seto, Jason 1; Email Address: jseto@gmu.edu Walsh, Michael P. 1; Email Address: mwalsh5@gmu.edu Mahadevan, Padmanabhan 1; Email Address: pmahadev@gmu.edu Purkayastha, Anjan 1,2; Email Address: purkayas@wi.mit.edu Clark, James M. 2; Email Address: jayemmsee@gmail.com Tibbetts, Clark 2; Email Address: clark.tibbetts@tessarae.com Seto, Donald 1,2; Email Address: dseto99@gmail.com; Affiliation: 1: Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd., MSN 5B3, Manassas, VA 20110, USA 2: Office of the Surgeon General, US Air Force, Directorate of Modernization (SGR) and the Epidemic Outbreak Surveillance (EOS) Consortium, 5201 Leesburg Pike, Suite 1401, Falls Church, VA 22041, USA; Source Info: Jul2009, Vol. 143 Issue 1, p94; Subject Term: ADENOVIRUSES; Subject Term: MICROBIAL genomics; Subject Term: BIOINFORMATICS; Subject Term: EMERGING infectious diseases; Subject Term: RESPIRATORY diseases; Subject Term: VIRUS-induced enzymes; Subject Term: VIRUSES -- Identification; Author-Supplied Keyword: B1, B2 subspecies; Author-Supplied Keyword: Human adenovirus; Author-Supplied Keyword: Human therapy vector; Author-Supplied Keyword: Re-emerging pathogen; Author-Supplied Keyword: Respiratory disease; Author-Supplied Keyword: Viral bioinformatics; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.virusres.2009.03.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=40112070&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-09304-003
AN - 2009-09304-003
AU - Kodell, Ralph L.
AU - Pearce, Bruce A.
AU - Baek, Songjoon
AU - Moon, Hojin
AU - Ahn, Hongshik
AU - Young, John F.
AU - Chen, James J.
T1 - A model-free ensemble method for class prediction with application to biomedical decision making.
JF - Artificial Intelligence in Medicine
JO - Artificial Intelligence in Medicine
JA - Artif Intell Med
Y1 - 2009/07//
VL - 46
IS - 3
SP - 267
EP - 276
CY - Netherlands
PB - Elsevier Science
SN - 0933-3657
AD - Kodell, Ralph L., Department of Biostatistics, University of Arkansas for Medical Sciences, #781, 4301 W. Markham St., COPH 3218, Little Rock, AZ, US, 72205
N1 - Accession Number: 2009-09304-003. PMID: 19081231 Partial author list: First Author & Affiliation: Kodell, Ralph L.; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AZ, US. Release Date: 20091214. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Algorithms; Mathematical Modeling; Medical Treatment (General). Minor Descriptor: Classification (Cognitive Process); Decision Making; Prediction. Classification: Statistics & Mathematics (2240); Medical Treatment of Physical Illness (3363). Population: Human (10). Methodology: Mathematical Model. References Available: Y. Page Count: 10. Issue Publication Date: Jul, 2009. Publication History: Accepted Date: Nov 3, 2008; Revised Date: Oct 30, 2008; First Submitted Date: Apr 17, 2008. Copyright Statement: All rights reserved. Elsevier B.V. 2008.
AB - Objective: A classification algorithm that utilizes two-dimensional convex hulls of training-set samples is presented. Methods and material: For each pair of predictor variables, separate convex hulls of positive and negative samples in the training set are formed, and these convex hulls are used to classify test points according to a nearest-neighbor criterion. An ensemble of these two-dimensional convex-hull classifiers is formed by trimming the mC₂ possible classifiers derived from the m predictors to a set of classifiers comprised of only unique predictor variables. Because only two-dimensional spaces are required to be populated by training-set samples, the 'curse of dimensionality' is not an issue. At the same time, the power of ensemble voting is exploited by combining the classifications of the unique two-dimensional classifiers to reach a final classification. Results: The algorithm is illustrated by application to three publicly available biomedical data sets with genomic predictors and is shown to have prediction accuracy that is competitive with a number of published classification procedures. Conclusion: Because of its superior performance in terms of sensitivity and negative predictive value compared to its competitors, the convex-hull ensemble classifier demonstrates good potential for medical screening, where often the major emphasis is placed on having reliable negative predictions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - biomedical decision making
KW - algorithm
KW - two-dimensional convex hulls
KW - class prediction
KW - 2009
KW - Algorithms
KW - Mathematical Modeling
KW - Medical Treatment (General)
KW - Classification (Cognitive Process)
KW - Decision Making
KW - Prediction
KW - 2009
DO - 10.1016/j.artmed.2008.11.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-09304-003&site=ehost-live&scope=site
UR - rlkodell@uams.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11083-008
AN - 2009-11083-008
AU - Peng, Shu-Chen
AU - Lu, Nelson
AU - Chatterjee, Monita
T1 - Effects of cooperating and conflicting cues on speech intonation recognition by cochlear implant users and normal hearing listeners.
JF - Audiology & Neurotology
JO - Audiology & Neurotology
JA - Audiol Neurootol
Y1 - 2009/07//
VL - 14
IS - 5
SP - 327
EP - 337
CY - Switzerland
PB - Karger
SN - 1420-3030
SN - 1421-9700
AD - Peng, Shu-Chen, Cochlear Implants and Psychophysics, Laboratory Department of Hearing and Speech Sciences, University of Maryland, College Park, MD, US, 20742
N1 - Accession Number: 2009-11083-008. PMID: 19372651 Partial author list: First Author & Affiliation: Peng, Shu-Chen; Center for Device and Radiological Health, US Food and Drug Administration, Rockville, MD, US. Release Date: 20100308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Chatterjee, Monita. Major Descriptor: Acoustics; Cochlear Implants; Speech Characteristics; Speech Perception. Minor Descriptor: Cues. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Jul, 2009. Publication History: First Posted Date: Apr 15, 2009; Accepted Date: Dec 22, 2008; Revised Date: Dec 22, 2008; First Submitted Date: Mar 19, 2008. Copyright Statement: S. Karger AG, Basel. 2009.
AB - Cochlear implant (CI) recipients have only limited access to fundamental frequency (F0) information, and thus exhibit deficits in speech intonation recognition. For speech intonation, F0 serves as the primary cue, and other potential acoustic cues (e.g. intensity properties) may also contribute. This study examined the effects of cooperating or conflicting acoustic cues on speech intonation recognition by adult CI and normal hearing (NH) listeners with full-spectrum and spectrally degraded speech stimuli. Identification of speech intonation that signifies question and statement contrasts was measured in 13 CI recipients and 4 NH listeners, using resynthesized bi-syllabic words, where F0 and intensity properties were systematically manipulated. The stimulus set was comprised of tokens whose acoustic cues (i.e. F0 contour and intensity patterns) were either cooperating or conflicting. Subjects identified if each stimulus is a ‘statement’ or a ‘question’ in a single-interval, 2-alternative forced choice (2AFC) paradigm. Logistic models were fitted to the data, and estimated coefficients were compared under cooperating and conflicting conditions, between the subject groups (CI vs. NH), and under full-spectrum and spectrally degraded conditions for NH listeners. The results indicated that CI listeners’ intonation recognition was enhanced by cooperating F0 contour and intensity cues, but was adversely affected by these cues being conflicting. On the other hand, with full-spectrum stimuli, NH listeners’ intonation recognition was not affected by cues being cooperating or conflicting. The effects of cues being cooperating or conflicting were comparable between the CI group and NH listeners with spectrally degraded stimuli. These findings suggest the importance of taking multiple acoustic sources for speech recognition into consideration in aural rehabilitation for CI recipients. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conflicting cues
KW - speech intonation recognition
KW - cochlear implants
KW - acoustic cues
KW - speech stimuli
KW - 2009
KW - Acoustics
KW - Cochlear Implants
KW - Speech Characteristics
KW - Speech Perception
KW - Cues
KW - 2009
U1 - Sponsor: National Institutes of Health, National Institute on Deafness and Other Communication Disorders, US. Grant: R01DC04786. Recipients: Chatterjee, Monita (Prin Inv)
DO - 10.1159/000212112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11083-008&site=ehost-live&scope=site
UR - speng@hesp.umd.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-10703-007
AN - 2009-10703-007
AU - Harwood, Henrick J.
AU - Zhang, Yiduo
AU - Dall, Timothy M.
AU - Olaiya, Samuel T.
AU - Fagan, Nancy K.
T1 - Economic implications of reduced binge drinking among the military health system's TRICARE Prime plan beneficiaries.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2009/07//
VL - 174
IS - 7
SP - 728
EP - 736
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Harwood, Henrick J., National Association of State Alcohol and Drug Abuse Directors, 1025 Connecticut Avenue NW, Suite 605, Washington, DC, US, 20036
N1 - Accession Number: 2009-10703-007. PMID: 19685845 Partial author list: First Author & Affiliation: Harwood, Henrick J.; National Association of State Alcohol and Drug Abuse Directors, Washington, DC, US. Release Date: 20100125. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Binge Drinking; Costs and Cost Analysis; Government Programs; Military Personnel. Classification: Military Psychology (3800); Substance Abuse & Addiction (3233). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2009.
AB - This study examines the economic burden of alcohol misuse to the Department of Defense (DoD) and the benefits of reduced binge drinking among beneficiaries in the DoD's TRICARE Prime plan. Data analyzed include administrative records for approximately 3 million beneficiaries age 18 to 64, DoD's Survey of Health Related Behaviors Among Military Personnel, and the National Survey on Drug Use and Health. Alcohol misuse among Prime beneficiaries cost the DoD an estimated 1.2 billion in 2006425 million in higher medical costs and 745 million in reduced readiness and misconduct charges. Potential annual gross benefits to the DoD of reduced binge drinking are simulated for three scenarios: (1) implementing a comprehensive alcohol screening with referral to brief intervention or treatment by primary care (87 million/129 million in short/long-term benefits); (2) increasing the price of alcoholic beverages on military installations by 20 (75 million/115 million); and (3) implementing a Web-based education program (81 million/123 million). (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - economic implications
KW - binge drinking
KW - military health system
KW - TRICARE prime plan
KW - Department of Defense
KW - 2009
KW - Binge Drinking
KW - Costs and Cost Analysis
KW - Government Programs
KW - Military Personnel
KW - 2009
U1 - Sponsor: Office of the Assistant Secretary of Defense (Health Affairs). Recipients: No recipient indicated
U1 - Sponsor: TRICARE Management Activity. Recipients: No recipient indicated
U1 - Sponsor: Health Program Analysis and Evaluation Division. Recipients: No recipient indicated
U1 - Sponsor: Office of the Chief Medical Officer, US. Grant: HHSP23320045017XI. Recipients: No recipient indicated
DO - 10.7205/MILMED-D-03-9008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-10703-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-06200-028
AN - 2009-06200-028
AU - Pan, Christopher S.
AU - Chiou, Sharon
AU - Kau, Tsui-Ying
AU - Bhattacharya, Amit
AU - Ammons, Doug
T1 - Effects of foot placement on postural stability of construction workers on stilts.
JF - Applied Ergonomics
JO - Applied Ergonomics
JA - Appl Ergon
Y1 - 2009/07//
VL - 40
IS - 4
SP - 781
EP - 789
CY - Netherlands
PB - Elsevier Science
SN - 0003-6870
AD - Pan, Christopher S., Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-G800, Morgantown, WV, US, 26505
N1 - Accession Number: 2009-06200-028. PMID: 18952203 Partial author list: First Author & Affiliation: Pan, Christopher S.; Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, US. Release Date: 20090824. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Blue Collar Workers; Feet (Anatomy); Posture; Safety; Working Conditions. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Jul, 2009.
AB - Stilts are elevated tools that are frequently used by construction workers to raise workers 18–40 inches above the ground. The objective of this laboratory study was to evaluate the potential loss of postural stability associated with the use of stilts in various foot placements. Twenty construction workers with at least 1 year of experience in the use of stilts participated in this study. One KistlerTM force platform was used to collect kinetic data. Participants were tested under six-foot-placement conditions. These 6 experimental conditions were statically tested under all combinations of 3 levels of elevation: 0″ (no stilts), 24″ stilt height and 40″ stilt height. SAS mixed procedure was used to evaluate the effect of different experimental conditions. The results of the multivariate analysis of variance (MANOVA) and repeated measures of univariate analyses of variance (ANOVAs) demonstrated that stilt height, foot placement direction, and foot-placement width all had significant effects on the whole-body postural stability. This study found that the higher the stilts were elevated, the greater the postural instability. A stance position with one foot placed forward of the other foot produced greater postural instability than a position with the feet parallel and directly beneath the body. This study found that placement of the feet parallel and directly beneath the body, with the feet positioned a half shoulder width apart, caused a greater amount of postural sway and instability than one and one-and-half shoulder width. This study also found that construction workers using the stilts could perceive the likely postural instability due to the change in foot placements. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - foot placement
KW - postural stability
KW - construction workers
KW - levels of elevation
KW - safety
KW - stilts
KW - 2009
KW - Blue Collar Workers
KW - Feet (Anatomy)
KW - Posture
KW - Safety
KW - Working Conditions
KW - 2009
DO - 10.1016/j.apergo.2008.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-06200-028&site=ehost-live&scope=site
UR - cpan@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-12498-001
AN - 2009-12498-001
AU - Cohen, Joel W.
AU - Cohen, Steven B.
AU - Banthin, Jessica S.
T1 - The Medical Expenditure Panel Survey: A national information resource to support healthcare cost research and inform policy and practice.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2009/07//
VL - 47
IS - 7,Suppl1
SP - S44
EP - S50
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Cohen, Joel W., Division of Social and Economic Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US
N1 - Accession Number: 2009-12498-001. Partial author list: First Author & Affiliation: Cohen, Joel W.; Division of Social and Economic Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, US. Release Date: 20100405. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Health Care Costs; Health Care Services; Health Care Utilization; Health Care Policy. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul, 2009. Copyright Statement: Lippincott Williams & Wilkins. 2009.
AB - Background: The Medical Expenditure Panel Survey (MEPS) collects detailed information regarding the use and payment for health care services from a nationally representative sample of Americans. The survey is designed to provide analysts with the data they need to support policy-relevant research on health care expenses, utilization, insurance coverage, and access in the United States and to provide policymakers with the results and data they need to make informed decisions. Objectives: This article summarizes the capacity of this broad-based and publicly available information resource to support research efforts directed towards achieving a better understanding of the dynamics of American healthcare and to better characterize its current state. Methods: The MEPS comprises a nationally representative sample of the civilian noninstitutionalized population in the United States, and collects comprehensive data on individuals and their health care experiences over a span of 2 years. Household survey data are collected by means of computer-assisted personal interviews, and those data are supplemented by information collected directly from the medical providers used by survey participants. Insurance data are collected both from households and through a separate state and nationally representative survey of business establishments, which collects information on health insurance provided by United States employers. Results: The MEPS has been used extensively in scientific publications and published reports, as well as by the Federal and state governments to examine the delivery and financing of healthcare in the United States. Conclusions: The analytical findings generated by the MEPS are key inputs to facilitate the development, implementation, and evaluation of policies and practices addressing health care in the United States and its related costs. Recent efforts to reconcile MEPS and the National Health Expenditure Accounts have the potential to provide an even more accurate and powerful data tool for research and policy analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Medical Expenditure Panel Survey
KW - healthcare use & cost
KW - health policy analysis
KW - research
KW - 2009
KW - Experimentation
KW - Health Care Costs
KW - Health Care Services
KW - Health Care Utilization
KW - Health Care Policy
KW - 2009
DO - 10.1097/MLR.0b013e3181a23e3a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-12498-001&site=ehost-live&scope=site
UR - joel.cohen@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Simeonova, Petia P.
AU - Erdely, Aaron
T1 - Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: Predictive tests and biomarkers.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2009/07/02/Jul2009 Supplement 1
VL - 21
M3 - Article
SP - 68
EP - 73
SN - 08958378
AB - The most attractive properties of engineered nanomaterials for technological applications, including their small size, large surface area, and high reactivity, are also the main factors for their potential toxicity. Based on ambient ultrafine particle research, it is predicted that nanosized particles may have deeper pulmonary deposition, higher biological activity, and a tendency for extrapulmonary translocation compared to larger particles. In this regard, nanoparticle exposure, by direct or indirect mechanisms, may lead to unexpected distant responses, involving the immune system, cardiovascular system, liver, kidney, and brain. The systemic effects may induce or modify the progression of existing diseases such as cardiovascular disease. Current experimental toxicity evaluation of engineered nanomaterials, specifically carbon nanotubes, demonstrated that deposition of these materials in the lung leads to inflammation and fibrosis. The local toxicity is associated with cardiovascular effects related to atherosclerosis. Although translocation of carbon nanotubes into the systemic circulation is hypothetically possible, there is no current evidence to support this hypothesis. However, studies pointed out that carbon nanotube-induced lung inflammation results in a release of inflammatory mediators and activation of blood cells which can contribute to cardiovascular adverse effects. Furthermore, complex protein and gene expression blood analysis can help in development of biomarkers for application in human screening of nanoparticle exposure. Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Biochemical markers
KW - Poisonous gases -- Toxicology
KW - Nanoparticles
KW - Cardiovascular toxicology
KW - Respiratory diseases
KW - Atherosclerosis
KW - biomarkers
KW - blood gene expression
KW - inflammatory cytokines
KW - nanomaterials
KW - nanotoxicology
KW - predictive tests
N1 - Accession Number: 43448323; Simeonova, Petia P. 1; Email Address: PSimeonova@cdc.gov; Erdely, Aaron 1; Affiliations: 1: Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Issue Info: Jul2009 Supplement 1, Vol. 21, p68; Thesaurus Term: Biochemical markers; Thesaurus Term: Poisonous gases -- Toxicology; Subject Term: Nanoparticles; Subject Term: Cardiovascular toxicology; Subject Term: Respiratory diseases; Author-Supplied Keyword: Atherosclerosis; Author-Supplied Keyword: biomarkers; Author-Supplied Keyword: blood gene expression; Author-Supplied Keyword: inflammatory cytokines; Author-Supplied Keyword: nanomaterials; Author-Supplied Keyword: nanotoxicology; Author-Supplied Keyword: predictive tests; Number of Pages: 6p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1080/08958370902942566
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43448323&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Witasp, Erika
AU - Shvedova, Anna A.
AU - Kagan, Valerian E.
AU - Fadeel, Bengt
T1 - Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2009/07/02/Jul2009 Supplement 1
VL - 21
M3 - Article
SP - 131
EP - 136
SN - 08958378
AB - Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities and the application of these materials in a large number of new technologies and consumer products necessitates studies of their potential impact on human health and the environment. To determine whether SWCNT affect viability or function of macrophages, important components of the innate immune system, we performed in vitro studies using primary human monocyte-derived macrophages (HMDM). Our findings show that SWCNT with a low content of metal impurities do not exert direct cytotoxic effects on HMDM. However, SWCNT suppressed chemotaxis of primary human monocytes in a standard chemotaxis assay. Moreover, macrophage engulfment of apoptotic target cells was significantly impaired following pre-incubation of HMDM with SWCNT at non-cytotoxic concentrations. These results are in line with previous studies showing that ultrafine carbon particles and carbon nanotubes may impair alveolar macrophage ingestion of microorganisms, and suggest that tissue homeostasis may be compromised by SWCNT due to suppressive effects on macrophages. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cell death
KW - Carbon nanotubes
KW - Macrophages
KW - Immune system
KW - Monocytes
KW - chemotaxis
KW - cytotoxicity
KW - human monocyte-derived macrophages
KW - phagocytosis
KW - Single-walled carbon nanotubes
N1 - Accession Number: 43448327; Witasp, Erika 1; Shvedova, Anna A. 2; Kagan, Valerian E. 1,3; Fadeel, Bengt 1; Email Address: bengt.fadeel@ki.se; Affiliations: 1: Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; 2: Pathology/Physiology Research Branch, Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA.; 3: Center for Free Radical and Antioxidant Health, Graduate School of Public Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Issue Info: Jul2009 Supplement 1, Vol. 21, p131; Thesaurus Term: Cell death; Subject Term: Carbon nanotubes; Subject Term: Macrophages; Subject Term: Immune system; Subject Term: Monocytes; Author-Supplied Keyword: chemotaxis; Author-Supplied Keyword: cytotoxicity; Author-Supplied Keyword: human monocyte-derived macrophages; Author-Supplied Keyword: phagocytosis; Author-Supplied Keyword: Single-walled carbon nanotubes; Number of Pages: 6p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1080/08958370902942574
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43448327&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105375689
T1 - The medical expenditure panel survey: a national information resource to support healthcare cost research and inform policy and practice.
AU - Cohen JW
AU - Cohen SB
AU - Banthin JS
Y1 - 2009/07/02/2009 Jul
N1 - Accession Number: 105375689. Language: English. Entry Date: 20090807. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 0230027.
KW - Health Care Costs
KW - Health Services Research -- Methods
KW - Insurance, Health -- Economics
KW - Health Policy
KW - Insurance Coverage
KW - Surveys
KW - United States Agency for Healthcare Research and Quality
KW - United States
KW - Human
SP - S44
EP - 50
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 7 Suppl 1
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - BACKGROUND: The Medical Expenditure Panel Survey (MEPS) collects detailed information regarding the use and payment for health care services from a nationally representative sample of Americans. The survey is designed to provide analysts with the data they need to support policy-relevant research on health care expenses, utilization, insurance coverage, and access in the United States and to provide policymakers with the results and data they need to make informed decisions. OBJECTIVES: This article summarizes the capacity of this broad-based and publicly available information resource to support research efforts directed towards achieving a better understanding of the dynamics of American healthcare and to better characterize its current state. METHODS: The MEPS comprises a nationally representative sample of the civilian noninstitutionalized population in the United States, and collects comprehensive data on individuals and their health care experiences over a span of 2 years. Household survey data are collected by means of computer-assisted personal interviews, and those data are supplemented by information collected directly from the medical providers used by survey participants. Insurance data are collected both from households and through a separate state and nationally representative survey of business establishments, which collects information on health insurance provided by United States employers. RESULTS: The MEPS has been used extensively in scientific publications and published reports, as well as by the Federal and state governments to examine the delivery and financing of healthcare in the United States. CONCLUSIONS: The analytical findings generated by the MEPS are key inputs to facilitate the development, implementation, and evaluation of policies and practices addressing health care in the United States and its related costs. Recent efforts to reconcile MEPS and the National Health Expenditure Accounts have the potential to provide an even more accurate and powerful data tool for research and policy analysis.
SN - 0025-7079
AD - Division of Social and Economic Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. joel.cohen@ahrq.hhs.gov
U2 - PMID: 19536015.
DO - 10.1097/MLR.0b013e3181a23e3a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105375689&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fang Gong
AU - Baron, Sherry
AU - Stock, Laura
AU - Ayala, Linda
T1 - Formative Research in Occupational Health and Safety Intervention for Diverse, Underserved Worker Populations: A Homecare Worker Intervention Project.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009/07/02/Jul/Aug2009 Supplement 1
VL - 124
M3 - Article
SP - 84
EP - 89
SN - 00333549
AB - Objective. The increasing numbers of minority, low-income, and contingent workers in the U.S. labor force present new challenges to occupationaI safety and health interventions. Formative research can be used-to help researchers better understand target populations and identify unanticipated barriers to safety changes. The National Institute for Occupational Safety and Health initiated an intervention project to improve health and safety among homecare workers in Alameda County, California. lnvestigators conducted systematic formative research to gather information to guide intervertion development. Methods. Various qualitative methods were used including 11 focus groups (conducted in English, Spanish, and Chinese) and 10 key informant interviews. This article focuses on two picture-based focus group activities that explored workers' views on their relationships with consumers and their perceived barriers to interventions. Results. Findings indicated cultural differences regarding workers' perceptions of their relationships with consumers. Chinese home are workers mostly focused on respecting elders rather than initiating changes. Some English-and Spanish-speaking workers described efforts to negotiate with consumers. Results also identified workers' perceived barriers to interventions, such as consumers' resistance to changes and lack of resources. These findings played important roles in shaping the intervention materials. For example, given the lack of resources among consumers, the project tried to tap into community-level resources by collaborating with local stakeholders and developing community resource guides. Conclusion. Formative research can be a valuable step to inform the development of occupational health and safety interventions for diverse, underserved worker populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYEE health promotion
KW - FOREIGN workers
KW - INDUSTRIAL hygiene
KW - CROSS-cultural differences
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 42835840; Fang Gong 1,2 Baron, Sherry 1; Email Address: sbaron@cdc.gov Stock, Laura 3 Ayala, Linda 4; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 2: Department of Sociology, Ball State University, Muncie, IN 3: Labor Occupational Health Program, University of California, Berkeley, CA 4: Public Authority for In-Home Supportive Services in Alameda County, Oakland, CA; Source Info: Jul/Aug2009 Supplement 1, Vol. 124, p84; Subject Term: EMPLOYEE health promotion; Subject Term: FOREIGN workers; Subject Term: INDUSTRIAL hygiene; Subject Term: CROSS-cultural differences; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; Number of Pages: 6p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42835840&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Thomas, Carrie A.
AU - Bailey, Rachel L.
AU - Kent, Michael S.
AU - Deubner, David C.
AU - Kreiss, Kathleen
AU - Schuler, Christine R.
T1 - Efficacy of a Program to Prevent BeryIlium Sensitization Among New Employees at a Copper-Beryllium Alloy Processing Facility.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009/07/02/Jul/Aug2009 Supplement 1
VL - 124
M3 - Article
SP - 112
EP - 124
SN - 00333549
AB - Objectives. In 2000, 7% of workers at a copper-beryllium facility were beryllium sensitized. Risk was associated with work near a wire annealing/pickling process. The facility then implemented a preventive program including particle migration control, respiratory and dermal protection, and process enclosure. We assessed the program's efficacy in preventing beryllium sensitization. Methods. In 2000, the facility began testing new hires (program workers) with beryllium lymphocyte proliferation tests (BeLPTs) at hire and at intervals during employment. We compared sensitization incidence rates (IRs) and prevalence rates for workers hired before the program (legacy workers) with rates for pro- gram workers, including program worker subgroups. We also examined trends in BeLPTs from a single laboratory. Results. In all, five of 43 legacy workers (IR=3.8/1 ,000 person-months) and three of 82 program workers (IR=1.9/1,000 person-months) were beryllium sensitized, for an incidence rate ratio (IRR) of 2.0 (95% confidence interval [Cl] 0.5, 10.1). Two of 37 pre-enclosure program workers (IR=2.4/1,000 person-months) and one of 45 post-enclosure program workers (IR=1.4/1,000 person-months) were beryllium sensitized, for IRRs of 1.6 (95% CI 0.3, 11 .9) and 2.8 (95% CI 0.4, 66.2), respectively, compared with legacy workers. Test for trend in prevalence rates was significant. Among 2,159 first-draw BeLPTs during 95 months, we identified seven months when high numbers of redraws were required, with one possible misclassification in this facility. Conclusions. Fewer workers became sensitized after implementation of the preventive program. However, low statistical power due to the facility's small workforce prevents a definitive conclusion about the program's efficacy. These findings have implications for other copper-beryllium facilities, where program components may merit application. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMPLOYEE health promotion
KW - COPPER-beryllium alloys
KW - ANNEALING of metals
KW - METALWORK
KW - HAZARD mitigation
N1 - Accession Number: 42835843; Thomas, Carrie A. 1; Email Address: Carrie.Thomas@cdc.hhs.gov Bailey, Rachel L. 1 Kent, Michael S. 2 Deubner, David C. 2 Kreiss, Kathleen 1 Schuler, Christine R. 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety anti Health, Morgantown, WV 2: Brush Wellman Inc., Elmore, OH; Source Info: Jul/Aug2009 Supplement 1, Vol. 124, p112; Subject Term: EMPLOYEE health promotion; Subject Term: COPPER-beryllium alloys; Subject Term: ANNEALING of metals; Subject Term: METALWORK; Subject Term: HAZARD mitigation; NAICS/Industry Codes: 332810 Coating, engraving, cold and heat treating and allied activities; NAICS/Industry Codes: 332811 Metal Heat Treating; Number of Pages: 13p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105405218
T1 - Formative research in occupational health and safety intervention for diverse, underserved worker populations: a homecare worker intervention project.
AU - Gong F
AU - Baron S
AU - Ayala L
Y1 - 2009/07/02/Jul/Aug2009 Supplement 1
N1 - Accession Number: 105405218. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research. Supplement Title: Jul/Aug2009 Supplement 1. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Evidence-Based Practice; Public Health. Grant Information: Funded by National Institute for Occupational Safety and Health (NIOSH) of the CDC. NLM UID: 9716844.
KW - Homemaker Services
KW - Occupational Health
KW - Occupational Safety
KW - Attitude
KW - Focus Groups
KW - Funding Source
KW - Home Health Care
KW - Interpersonal Relations
KW - Interviews
KW - Qualitative Studies
KW - Human
SP - 84
EP - 89
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 124
PB - Sage Publications Inc.
SN - 0033-3549
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy., MS R-17, Cincinnati, OH 45226, USA.
U2 - PMID: 19618810.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105405221
T1 - Efficacy of a program to prevent beryllium sensitization among new employees at a copper-beryllium alloy processing facility.
AU - Thomas CA
AU - Bailey RL
AU - Kent MS
AU - Deubner DC
AU - Kreiss K
AU - Schuler CR
Y1 - 2009/07/02/Jul/Aug2009 Supplement 1
N1 - Accession Number: 105405221. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Jul/Aug2009 Supplement 1. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Beryllium -- Adverse Effects
KW - Copper -- Adverse Effects
KW - Metallurgy
KW - Occupational Exposure
KW - Occupational Health
KW - Adult
KW - Beryllium -- Blood
KW - Blue Collar Workers
KW - Chi Square Test
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Female
KW - Male
KW - One-Way Analysis of Variance
KW - Relative Risk
KW - Human
SP - 112
EP - 124
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 124
PB - Sage Publications Inc.
SN - 0033-3549
AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, 1095 Willowdale Rd., MS-2800, Morgantown, WV 26505, USA. Carrie.Thomas@cdc.hhs.gov
U2 - PMID: 19618813.
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DP - EBSCOhost
DB - rzh
ER -
TY - CASE
AU - Oncins, Maristella Cecco
AU - Douglas, Carlos Roberto
AU - Paiva, Guiovaldo
T1 - A ELETROMIOGRAFIA COMO AUXÍLIO NA CONDUTA TERAPÊUTICA APÓS CIRURGIA DE CRANIOTOMIA FRONTO-TEMPORAL: RELATO DE CASO.
T2 - Electromyography as an aid in therapeutic behavior after fronto-temporal craniotomy surgery: case report.
JO - Revista CEFAC
JF - Revista CEFAC
Y1 - 2009/07/02/2009 supplement 3
VL - 11
M3 - Case Study
SP - 457
EP - 465
SN - 15161846
AB - Background: electromyography and therapeutic behavior. Procedures: this study was carried out with a woman, 45year old, after 4 months from being submitted to fronto-temporal craniotomy originated an aneurysm. The right anterior temporal muscle was removed from its insertion. After the surgery, the patient had dysfunction in temporal muscle and in temporo-mandibular joint, with reduction of the opening of mouth, pain while speaking and eating. Electromyography was used to quantitatively record the electrical activity of the temporal and masseter muscles in the initial evaluation and during the therapeutic process. Records were made at rest position, maximum occlusion and chew. They did miofuncional therapy throughout the process. Results: examination data showed a significant increase in the electrical activity of the right anterior temporal muscle and a reduction in the activity of the left anterior temporal muscle. The initial Record showed a lower electrical activity on the right side compared to the left. With the miofunctional exercises there was a more effective participation of the right anterior temporal muscle, greater openness of mouth, without pain, making easier chewing and speech tasks, harmonizing the stomatognathic system. Conclusion: comparative records concerning electromyography in different stages of the therapeutic process helped and directed the best therapy, achieving a balance concerning the functions of breathing, sucking, chewing, swallowing and speech related to the stomatognathic system, considering the limitations of the case. (English) [ABSTRACT FROM AUTHOR]
AB - Tema: eletromiografia e conduta terapêutica. Procedimentos: este estudo foi realizado com uma paciente de 45 anos de idade, após 4 meses ser submetida a craniotomia fronto-temporal proveniente de um aneurisma. O músculo temporal anterior direito foi retirado da sua origem móvel e após a cirurgia, a paciente apresentou disfunção do músculo temporal e da articulação temporomandibular, com redução da abertura de boca, dor ao falar e comer. Utilizou-se a eletromiografia para registrar quantitativamente a atividade elétrica dos músculos temporais e masseteres na avaliação e durante o processo terapêutico. Registraram-se, na posição de repouso, oclusão máxima e mastigação habitual provocada. Fez-se terapia miofuncional durante todo o processo. Resultados: dados dos exames mostraram um aumento significativo da atividade elétrica do músculo temporal anterior direito e uma redução da atividade do músculo temporal anterior esquerdo, o que no primeiro registro mostrava uma atividade elétrica rebaixada do lado direito em comparação com o lado esquerdo. Com a seleção dos exercícios miofuncionais houve uma participação mais efetiva do músculo temporal anterior direito, abertura de boca maior, sem dor, facilitando a função da mastigação e da fala, harmonizando o sistema estomatognático. Conclusão: registros comparativos dos exames de eletromiografia em diferentes etapas do processo terapêutico auxiliaram e direcionaram a melhor conduta terapêutica fonoaudiológica. Conseguiu-se atingir um equilíbrio das funções de respiração, sucção, mastigação, deglutição e fala relacionadas ao sistema estomatognático, considerando as limitações do caso. (Portuguese) [ABSTRACT FROM AUTHOR]
AB - Copyright of Revista CEFAC is the property of Revista CEFAC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANEURYSMS
KW - OLDER women -- Diseases
KW - ELECTROMYOGRAPHY
KW - ELECTRODIAGNOSIS
KW - CASE studies
KW - Craniotomy
KW - Electromyography
KW - Stomatognathic System
KW - Temporomandibular Joint
KW - Articulação Temporomandibular
KW - Craniotomia
KW - Eletromiografia
KW - Sistema Estomatognático
N1 - Accession Number: 54296508; Oncins, Maristella Cecco 1; Email Address: marisfono@uol.com.br Douglas, Carlos Roberto 2 Paiva, Guiovaldo 3; Affiliation: 1: Fonoaudióloga; Membro científico do Centro de Diagnóstico e Tratamento da Articulação Temporomandibular, CDTATM, São Paulo, SP; Mestre em Fonoaudiologia Clínica pela Pontifícia Universidade Católica de São Paulo 2: Médico; Professor de Fisiologia e Fisiologia Evolutiva na Universidade Metodista de São Paulo, UMESP, São Paulo, SP; Pós Doutorado pelo Public Health Service (National Institude of Health), U.S.A. 3: Cirurgião Dentista; Diretor do Centro de Diagnóstico e Tratamento da Articulação Temporomandibular, CDTATM, São Paulo, SP; Especialista em Prótese Dental e Disfunção Temporomandibular e Dor Orofacial; Source Info: 2009 supplement 3, Vol. 11, p457; Subject Term: ANEURYSMS; Subject Term: OLDER women -- Diseases; Subject Term: ELECTROMYOGRAPHY; Subject Term: ELECTRODIAGNOSIS; Subject Term: CASE studies; Author-Supplied Keyword: Craniotomy; Author-Supplied Keyword: Electromyography; Author-Supplied Keyword: Stomatognathic System; Author-Supplied Keyword: Temporomandibular Joint; Author-Supplied Keyword: Articulação Temporomandibular; Author-Supplied Keyword: Craniotomia; Author-Supplied Keyword: Eletromiografia; Author-Supplied Keyword: Sistema Estomatognático; Language of Keywords: English; Language of Keywords: Portuguese; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 3 Charts, 3 Graphs; Document Type: Case Study; Language: Portuguese
L3 - 10.1590 / S1516- 18462009005000011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2014-15906-008
AN - 2014-15906-008
AU - Goes, Fernando S.
AU - Willour, Virginia L.
AU - Zandi, Peter P.
AU - Belmonte, Pamela L.
AU - MacKinnon, Dean F.
AU - Mondimore, Francis M.
AU - Schweizer, Barbara
AU - Gershon, Elliot S.
AU - McMahon, Francis J.
AU - Potash, James B.
T1 - Family‐based association study of Neuregulin 1 with psychotic bipolar disorder.
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JA - Am J Med Genet B Neuropsychiatr Genet
Y1 - 2009/07/05/
VL - 150B
IS - 5
SP - 693
EP - 702
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1552-4841
SN - 1552-485X
AD - Potash, James B., Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 4-119, 600 N. Wolfe St., Baltimore, MD, US, 21287
N1 - Accession Number: 2014-15906-008. PMID: 19127563 Partial author list: First Author & Affiliation: Goes, Fernando S.; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, US. Institutional Authors: Bipolar Disorder Phenome Group, NIMH Genetics Initiative Bipolar Disorder Consortium. Release Date: 20160808. Correction Date: 20160811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Potash, James B. Major Descriptor: Bipolar Disorder; Genetics; Nuclear Family; Haplotype. Minor Descriptor: Genes; Psychosis; Schizophrenia. Classification: Affective Disorders (3211). Location: US. Tests & Measures: Schedule for Affective Disorders and Schizophrenia-Lifetime Version; Research Diagnostic Criteria DOI: 10.1037/t04137-000. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Tables and Figures Internet. References Available: Y. Page Count: 10. Issue Publication Date: Jul 5, 2009. Publication History: First Posted Date: Jan 6, 2009; Accepted Date: Oct 21, 2008; First Submitted Date: Jul 21, 2008. Copyright Statement: Wiley-Liss, Inc. 2009.
AB - The Neuregulin 1 gene (NRG1) has been associated with schizophrenia, and, to a lesser extent, with bipolar disorder (BP). We investigated the association of NRG1 with BP in a large family sample, and then performed analyses according to the presence of psychotic features or mood‐incongruent psychotic features. We genotyped 116 tagSNPs and four Icelandic 'core' SNPs in 1,199 subjects from 314 nuclear families. Of 515 BP offspring, 341 had psychotic features, and 103 had mood‐incongruent psychotic features. In single‐marker and sliding window haplotype analyses using FBAT, there was little association using the standard BP or mood‐incongruent psychotic BP phenotypes, but stronger signals were seen in the psychotic BP phenotype. The most significant associations with psychotic BP were in haplotypes within the 5′ 'core' region. The strongest global P‐value was across three SNPs: NRG241930‐NRG243177‐rs7819063 (P = 0.0016), with an undertransmitted haplotype showing an individual P = 0.0007. The most significant individual haplotype was an undertransmitted two‐allele subset of the above (NRG243177‐rs7819063, P = 0.0004). Additional associations with psychotic BP were found across six SNPs in a 270 kb central region of the gene. The most 3′ of these, rs7005606 (P = 0.0029), is located ∼4 kb from the type I NRG1 isoform promoter. In sum, our study suggests that NRG1 may be specifically associated with the psychotic subset of BP; however, our results should be interpreted cautiously since they do not meet correction for multiple testing and await independent replication. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Neuregulin 1
KW - bipolar disorder
KW - genetic association
KW - mood‐incongruent psychosis
KW - psychosis
KW - 2009
KW - Bipolar Disorder
KW - Genetics
KW - Nuclear Family
KW - Haplotype
KW - Genes
KW - Psychosis
KW - Schizophrenia
KW - 2009
U1 - Sponsor: National Institute of Mental Health, Extramural Program, US. Grant: R01 MH-042243; R01MH-061613. Recipients: Potash, James B.
U1 - Sponsor: National Institute of Mental Health, Extramural Program, US. Recipients: Goes, Fernando S.
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Stanley Medical Research Institute. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: McMahon, Francis J.
U1 - Sponsor: Sponsor name not included. Other Details: Alexander Wilson Schweizer Fellowship, Margaret Price Investigatorships. Recipients: Goes, Fernando S.; Willour, Virginia L.; Potash, James B.
DO - 10.1002/ajmg.b.30895
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UR - ORCID: 0000-0002-9469-305X
UR -
UR - jpotash@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Kakhi, Maziar
T1 - Mathematical modeling of the fluid dynamics in the flow-through cell
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
Y1 - 2009/07/06/
VL - 376
IS - 1/2
M3 - Article
SP - 22
EP - 40
SN - 03785173
AB - Abstract: The fluid dynamics in the flow-through cell (USP apparatus 4) has been predicted using the mathematical modeling approach of computational fluid dynamics (CFD). The degree to which flow structures in this apparatus can be qualified as ‘ideal’ both spatially and temporally has been assessed. The simulations predict the development of the velocity field in this apparatus for configurations with and without beads during the discharge stroke of the pump. When the cell is operated only with the red ruby bead (‘open column’ mode), highly non-uniform flow is predicted just downstream of the bead in the latter stages of the pump''s pulse. In contrast, a strong degree of profile uniformity and symmetry is predicted throughout the entire pulse in the region of the tablet holder for both standard configurations involving beads. However, noticeable differences in the tablet shear stress distribution are predicted at times when the same instantaneous inlet flow rates are being pumped through the apparatus. This effect is caused by flow separation in the velocity boundary layer formed around the tablet under the influence of an adverse pressure gradient, an effect not predicted with constant (non-pulsating) flow. While the degree of tablet erosion correlates with the average flow rate, during a particular pulse both the free-stream velocity and the boundary layer thickness are also influential. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Pharmaceutics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUID dynamics -- Mathematical models
KW - COMPUTATIONAL fluid dynamics
KW - CELLS -- Mechanical properties
KW - BIOLOGICAL transport
KW - BOUNDARY layer (Aerodynamics)
KW - FLUID mechanics
KW - SIMULATION methods & models
KW - Adverse pressure gradient
KW - Computational fluid dynamics (CFD)
KW - Dissolution
KW - Flow separation
KW - Flow-through cell (USP 4)
KW - Open/packed column modes
KW - Velocity boundary layer
N1 - Accession Number: 41584714; Kakhi, Maziar 1; Email Address: Maziar.Kakhi@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, Building 22, Rm 2147, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Jul2009, Vol. 376 Issue 1/2, p22; Subject Term: FLUID dynamics -- Mathematical models; Subject Term: COMPUTATIONAL fluid dynamics; Subject Term: CELLS -- Mechanical properties; Subject Term: BIOLOGICAL transport; Subject Term: BOUNDARY layer (Aerodynamics); Subject Term: FLUID mechanics; Subject Term: SIMULATION methods & models; Author-Supplied Keyword: Adverse pressure gradient; Author-Supplied Keyword: Computational fluid dynamics (CFD); Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Flow separation; Author-Supplied Keyword: Flow-through cell (USP 4); Author-Supplied Keyword: Open/packed column modes; Author-Supplied Keyword: Velocity boundary layer; Number of Pages: 19p; Document Type: Article
L3 - 10.1016/j.ijpharm.2009.04.012
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rosenberg, Melissa
AU - Sparks, Robert
AU - McMahon, Ann
AU - Iskander, John
AU - Campbell, James D.
AU - Edwards, Kathryn M.
T1 - Serious adverse events rarely reported after trivalent inactivated influenza vaccine (TIV) in children 6–23 months of age
JO - Vaccine
JF - Vaccine
Y1 - 2009/07/09/
VL - 27
IS - 32
M3 - Article
SP - 4278
EP - 4283
SN - 0264410X
AB - Abstract: In October 2003 the Advisory Committee on Immunization Practices (ACIP) recommended influenza vaccination for all children ages 6–23 months. We evaluated the safety of this recommendation by querying the Vaccine Adverse Events Reporting System (VAERS) for serious adverse events (SAE) reported between July 1, 2003 and June 30, 2006 in 6–23 month old infants after trivalent inactivated influenza vaccine (TIV). Cases were reviewed and the causal relationship with vaccine assessed. One hundred and four SAE were reported; median time from vaccination to SAE onset was one day. The two most commonly reported SAE disease categories were fever (N =52) and seizure (N =35). Causality assessment revealed that none of the SAE was definitely related to TIV. Although the number of SAE increased over time, the most common types of events remained unchanged with no new or unexpected safety concerns identified with expanded TIV use. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Vaccination
KW - Influenza
KW - Adverse health care events
KW - COMPLICATIONS
KW - Vaccination of children
KW - Viral diseases in children
KW - Drugs -- Safety measures
KW - United States
KW - adverse event ( AE )
KW - Advisory Committee on Immunization Practices
KW - Advisory Committee on Immunization Practices ( ACIP )
KW - Causality
KW - disease category ( DC )
KW - proportional reporting ratio ( PRR )
KW - Serious adverse event
KW - serious adverse event ( SAE )
KW - Trivalent influenza vaccine
KW - trivalent influenza vaccine ( TIV )
KW - Vaccine Adverse Event Reporting System
KW - Vaccine Adverse Event Reporting System ( VAERS )
KW - United States. Advisory Committee on Immunization Practices
N1 - Accession Number: 42106672; Rosenberg, Melissa 1; Email Address: melissa.rosenberg@ht.msu.edu; Sparks, Robert 2; Email Address: robert.c.sparks@vanderbilt.edu; McMahon, Ann 3; Email Address: ann.mcmahon@fda.hhs.gov; Iskander, John 4; Email Address: jxi0@cdc.gov; Campbell, James D. 5; Email Address: campbellj@ug.cdc.gov; Edwards, Kathryn M. 6; Email Address: kathryn.edwards@vanderbilt.edu; Affiliations: 1: Center for Vaccine Development, University of Maryland, 685 W. Baltimore Street HSF1 Room 480, Baltimore, MD 21201, USA; 2: Research Coordinator, Vanderbilt University, 21st Avenue South, CCC 5323 MCN, Nashville, TN 37232, USA; 3: Division of Adverse Event Analysis II, Office of Surveillance and Epidemiology, CDER, Food and Drug Administration, Silver Spring, MD, USA; 4: Immunization Safety Office, Office of the Chief Science Officer, Center for Disease Control and Prevention, Atlanta, Georgia; 5: University of Maryland School of Medicine, Department of Pediatrics, Center for Vaccine Development, 685 W. Baltimore Street HSF1 Room 480, Baltimore, MD 21201, USA; 6: Sarah H. Sell Chair in Pediatrics, Vanderbilt Vaccine Research Program, Vanderbilt University, 21st Avenue South, CCC 5311 MCN, Nashville, TN 37232, USA; Issue Info: Jul2009, Vol. 27 Issue 32, p4278; Thesaurus Term: VACCINATION; Thesaurus Term: Vaccination; Subject Term: Influenza; Subject Term: Adverse health care events; Subject Term: COMPLICATIONS; Subject Term: Vaccination of children; Subject Term: Viral diseases in children; Subject Term: Drugs -- Safety measures; Subject: United States; Author-Supplied Keyword: adverse event ( AE ); Author-Supplied Keyword: Advisory Committee on Immunization Practices; Author-Supplied Keyword: Advisory Committee on Immunization Practices ( ACIP ); Author-Supplied Keyword: Causality; Author-Supplied Keyword: disease category ( DC ); Author-Supplied Keyword: proportional reporting ratio ( PRR ); Author-Supplied Keyword: Serious adverse event; Author-Supplied Keyword: serious adverse event ( SAE ); Author-Supplied Keyword: Trivalent influenza vaccine; Author-Supplied Keyword: trivalent influenza vaccine ( TIV ); Author-Supplied Keyword: Vaccine Adverse Event Reporting System; Author-Supplied Keyword: Vaccine Adverse Event Reporting System ( VAERS ) ; Company/Entity: United States. Advisory Committee on Immunization Practices; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.05.023
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Thomas, J. Terrig
AU - Canelos, Paola
AU - Luyten, Frank P.
AU - Moos Jr., Malcolm
T1 - Xenopus SMOC-1 Inhibits Bone Morphogenetic Protein Signaling Downstream of Receptor Binding and Is Essential for Postgastrulation Development in Xenopus.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/07/10/
VL - 284
IS - 28
M3 - Article
SP - 18994
EP - 19005
SN - 00219258
AB - The bone morphogenetic protein (BMP) family of signaling molecules and their antagonists are involved in patterning of the body axis and numerous aspects of organogenesis. Classical biochemical purification and protein sequencing of highly purified fractions containing potent bone forming activity from bovine cartilage identified several BMPs together with a number of other proteins. One such protein was SMOC-2 (secreted modular calcium-binding protein-2), classified as belonging to the BM-40 family of modular extracellular proteins. Data regarding the biological function of SMOC-2 and closely related SMOC-1 remain limited, and their expression or function during embryological development is unknown, We therefore isolated the Xen opus ortholog of human SMOC-1 (XSMOC-1) and explored its function in Xenopus embryos. In gain-of-function assays, XSMOC-1 acted similarly to a BMP antagonist. However, in contrast to known extracellular ligand-binding BMP antagonists, such as noggin, SMOC antagonizes BMP activity in the presence of a constitutively active BMP receptor, indicating a mechanism of action downstream of the receptor. We provide several lines of evidence to suggest that SMOC acts downstream of the BMP receptor via MAPK-mediated phosphorylation of the Smad linker region. Loss-of-function studies, using antisense morpholino oligonucleotides, revealed XSMOC-1 to be essential for postgastrulation development. The catastrophic developmental failure observed following XSMOC knockdown resembles that observed following simultaneous depletion of three ligand-binding BMP antagonists described in prior studies. These findings provide a direct link between the extracellular matrix-associated protein SMOC and a signaling pathway of general importance in anatomic patterning and cell or tissue fate specffication. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BONE morphogenetic proteins
KW - RADIOLIGAND assay
KW - XENOPUS
KW - EMBRYOLOGY
KW - LIGAND binding (Biochemistry)
KW - PHOSPHORYLATION
KW - ENZYME inhibitors
N1 - Accession Number: 45152856; Thomas, J. Terrig 1; Email Address: john.thomas@fda.hhs.gov Canelos, Paola 1 Luyten, Frank P. 2 Moos Jr., Malcolm 1; Email Address: malcolm.moos@fda.hhs.gov; Affiliation: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892, USA 2: Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium; Source Info: 7/10/2009, Vol. 284 Issue 28, p18994; Subject Term: BONE morphogenetic proteins; Subject Term: RADIOLIGAND assay; Subject Term: XENOPUS; Subject Term: EMBRYOLOGY; Subject Term: LIGAND binding (Biochemistry); Subject Term: PHOSPHORYLATION; Subject Term: ENZYME inhibitors; Number of Pages: 12p; Document Type: Article
L3 - 10.1074/jbcM807759200
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kakhi, Maziar
T1 - Classification of the flow regimes in the flow-through cell
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
Y1 - 2009/07/12/
VL - 37
IS - 5
M3 - Article
SP - 531
EP - 544
SN - 09280987
AB - Abstract: This paper examines the dissolution apparatus referred to as the flow-through cell from an engineering fluid mechanics viewpoint. The analysis demonstrates that laminar flow predominantly occurs in the standard operation of this apparatus. It is argued that fully turbulent conditions are unlikely. Consequently, the phrases ‘open column’ and ‘packed column’ are suggested as technically more accurate terms for its operational characteristics than the conventionally referenced ‘turbulent mode’ and ‘laminar mode’. Examples of flow profiles are given to show that the criterion of a “sinusoidal” input flow profile required by USP is not a sufficiently accurate characterization at the inlet as numerous profiles can be conceived which have the same average flow rate. The rationale of pulsating flows versus constant, steady flows is discussed. Examples of how references to turbulence in the dissolution-related literature can lead to ambiguities and/or inconsistencies are highlighted. [Copyright &y& Elsevier]
AB - Copyright of European Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Solubility
KW - FLUID mechanics
KW - LAMINAR flow
KW - TURBULENCE
KW - UNSTEADY flow (Fluid dynamics)
KW - CONTINUUM mechanics
KW - PACKED towers (Chemical engineering)
KW - Dissolution
KW - Flow-through cell
KW - Laminar
KW - Open column
KW - Packed column
KW - Pulsating flow
KW - Transitional
KW - Turbulent
KW - USP 4
N1 - Accession Number: 42104378; Kakhi, Maziar 1; Email Address: Maziar.Kakhi@fda.hhs.gov; Affiliation: 1: Food and Drug Administration, Division of Pharmaceutical Analysis, Building 22, Rm 2147, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA; Source Info: Jul2009, Vol. 37 Issue 5, p531; Subject Term: DRUGS -- Solubility; Subject Term: FLUID mechanics; Subject Term: LAMINAR flow; Subject Term: TURBULENCE; Subject Term: UNSTEADY flow (Fluid dynamics); Subject Term: CONTINUUM mechanics; Subject Term: PACKED towers (Chemical engineering); Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Flow-through cell; Author-Supplied Keyword: Laminar; Author-Supplied Keyword: Open column; Author-Supplied Keyword: Packed column; Author-Supplied Keyword: Pulsating flow; Author-Supplied Keyword: Transitional; Author-Supplied Keyword: Turbulent; Author-Supplied Keyword: USP 4; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.ejps.2009.04.003
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105386941
T1 - Screening for gestational diabetes mellitus.
AU - Lin KW
AU - Sessions CK
Y1 - 2009/07/15/
N1 - Accession Number: 105386941. Language: English. Entry Date: 20090814. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Diabetes Mellitus, Gestational -- Diagnosis
KW - Adult
KW - Female
KW - Glucose Tolerance Test
KW - Health Screening -- Standards
KW - Pregnancy
KW - Risk Assessment
SP - 185
EP - 185
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 80
IS - 2
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - U.S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, USA.
U2 - PMID: 19621860.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Hayward, Douglas G.
AU - Wong, Jon W.
T1 - Organohalogen and Organophosphorous Pesticide Method for Ginseng Root - A Comparison of Gas Chromatography-Single Quadrupole Mass Spectrometry with High Resolution Time-of-Flight Mass Spectrometry.
JO - Analytical Chemistry
JF - Analytical Chemistry
Y1 - 2009/07/15/
VL - 81
IS - 14
M3 - Article
SP - 5716
EP - 5723
SN - 00032700
AB - A method has been developed for the analysis of 170 organohalogen and organophosphorous pesticides, isomers, and metabolites in dried ground ginseng root. Pesticides were extracted with ethyl acetate and purified with gel permeation chromatography (GPC) and primary! secondary amine modified silica (PSA)/graphitized carbon black (GCB) combination SPE column. Each purified pesticide extract was determined by both gas chromatography single quadrupole mass spectrometry using selected ion monitoring (GC-qMS-SIM) and by gas chromatography high resolution time-of-ifight mass spectrometiy (GC-HR-TOFMS). The geometric mean LOQs using the qMS and TOFMS were 4 and 3 ng/g ginseng, respectively. Mean recoveries from ginseng were 83,79, and 75% with standard deviations of 4,5, and 3%, respectively, for 25, 100, and 500 ng/g using GC-qMS-SIM. Mean recoveries using GC-HR-TOFMS were 93, 85, and 81% with mean standard deviations of 7,7, and 8% for 25, 100, and 500 ng/g respectively. Seven dried ginseng root products were found to contain combinations of the following pesticides: dacthal, diazinon, DDT, hexachlorohenzene, iprodione, lindane, procymidone, and quintozene (1-460 ng/g). No significant differences were found in the concentrations measured for these pesticides on commercial ginsengs using either of the two GC/MS techniques. [ABSTRACT FROM AUTHOR]
AB - Copyright of Analytical Chemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ORGANOHALOGEN compounds
KW - PESTICIDES
KW - GINSENG
KW - MASS spectrometry
KW - CHROMATOGRAPHIC analysis
N1 - Accession Number: 44721621; Hayward, Douglas G. 1; Email Address: douglas.hayward@fda.hhs.gov Wong, Jon W. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Parkway, HFS-706, College Park, Maryland 20740-5350; Source Info: 7/15/2009, Vol. 81 Issue 14, p5716; Subject Term: ORGANOHALOGEN compounds; Subject Term: PESTICIDES; Subject Term: GINSENG; Subject Term: MASS spectrometry; Subject Term: CHROMATOGRAPHIC analysis; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 113210 Forest Nurseries and Gathering of Forest Products; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; Number of Pages: 8p; Illustrations: 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Beland, Frederick A.
T1 - DNA hypomethylation in the origin and pathogenesis of human diseases.
JO - Cellular & Molecular Life Sciences
JF - Cellular & Molecular Life Sciences
Y1 - 2009/07/15/
VL - 66
IS - 14
M3 - Article
SP - 2249
EP - 2261
SN - 1420682X
AB - The pathogenesis of any given human disease is a complex multifactorial process characterized by many biologically significant and interdependent alterations. One of these changes, specific to a wide range of human pathologies, is DNA hypomethylation. DNA hypomethylation signifies one of the major DNA methylation states that refers to a relative decrease from the “normal” methylation level. It is clear that disease by itself can induce hypomethylation of DNA; however, a decrease in DNA methylation can also have an impact on the predisposition to pathological states and disease development. This review presents evidence suggesting the involvement of DNA hypomethylation in the pathogenesis of several major human pathologies, including cancer, atherosclerosis, Alzheimer’s disease, and psychiatric disorders. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cellular & Molecular Life Sciences is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA
KW - METHYLATION
KW - CANCER
KW - ATHEROSCLEROSIS
KW - ALZHEIMER'S disease
KW - MENTAL illness
KW - Alzheimer’s disease
KW - Alzheimer's disease
KW - Atherosclerosis
KW - Cancer
KW - DNA hypomethylation
KW - G-specific hypomethylation
KW - Psychiatric disorders
N1 - Accession Number: 43029458; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA; Source Info: Jul2009, Vol. 66 Issue 14, p2249; Subject Term: DNA; Subject Term: METHYLATION; Subject Term: CANCER; Subject Term: ATHEROSCLEROSIS; Subject Term: ALZHEIMER'S disease; Subject Term: MENTAL illness; Author-Supplied Keyword: Alzheimer’s disease; Author-Supplied Keyword: Alzheimer's disease; Author-Supplied Keyword: Atherosclerosis; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: DNA hypomethylation; Author-Supplied Keyword: G-specific hypomethylation; Author-Supplied Keyword: Psychiatric disorders; Number of Pages: 13p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1007/s00018-009-0015-5
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, James R.
AU - McCabe, James S.
AU - White, David G.
AU - Johnston, Brian
AU - Kuskowski, Michael A.
AU - McDermott, Patrick
T1 - Molecular Analysis of Escherichia coli from Retail Meats (2002-2004) from the United States National Antimicrobial Resistance Monitoring System.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/07/15/
VL - 49
IS - 2
M3 - Article
SP - 195
EP - 201
SN - 10584838
AB - Background. The origins and virulence potential of meat product-associated Escherichia coli are undefined. Methods. Two hundred eighty-seven E. coli isolates (145 resistant and 142 susceptible to trimethoprim-sulfamethoxazole, nalidixic acid, and/or ceftiofur), recovered by the United States National Antimicrobial Monitoring System from retail beef, pork, chicken, and turkey products (from Oregon, Tennessee, Georgia, and Maryland, 2002-2004) underwent polymerase chain reaction testing for phylogenetic groupings and 59 virulence-associated genes. Results. However analyzed, resistant and susceptible isolates differed minimally according to the assessed characteristics. In contrast, the 4 meat types differed greatly for multiple individual traits and aggregate virulence scores. Poultry isolates exhibited virulence genes associated with avian pathogenic E. coli; beef isolates exhibited traits associated with E. coli from diseased cattle. Overall, 20% of isolates qualified as extraintestinal pathogenic E. coli, with poultry isolates exhibiting significantly higher virulence scores than beef and pork isolates (P ! .001). Conclusions. Within this systematically collected, geographically distributed sample of recent retail meat isolates, the carriage of extraintestinal pathogenic E. coli virulence genes in antimicrobial-resistant and antimicrobial-susceptible E. coli appeared similar, whereas isolates from different types of meat differed, consistent with on-farm acquisition of resistance within host species-specific E. coli populations. A substantial minority of meat-source E. coli (whether susceptible or resistant) may represent potential human pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Anti-infective agents
KW - Phylogeny
KW - Virulence (Microbiology)
KW - Escherichia coli diseases
KW - Disease susceptibility
KW - Co-trimoxazole
KW - Polymerase chain reaction
KW - United States
N1 - Accession Number: 43008303; Johnson, James R. 1,2; Email Address: johns007@umn.edu; McCabe, James S. 1,2; White, David G. 3; Johnston, Brian 1,2; Kuskowski, Michael A. 2,4; McDermott, Patrick 3; Affiliations: 1: Department of Medicine, University of Minnesota, Minnesota; 2: Veterans Affairs Medical Center, Minneapolis, Minnesota; 3: Center for Veterinary Medicine, United States Food and Drug Administration, Laurel, Maryland; 4: Department of Psychiatry, University of Minnesota, Minnesota; Issue Info: 7/15/2009, Vol. 49 Issue 2, p195; Thesaurus Term: Anti-infective agents; Thesaurus Term: Phylogeny; Thesaurus Term: Virulence (Microbiology); Subject Term: Escherichia coli diseases; Subject Term: Disease susceptibility; Subject Term: Co-trimoxazole; Subject Term: Polymerase chain reaction; Subject: United States; Number of Pages: 7p; Document Type: Article
L3 - 10.1086/599830
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kashimshetty, Rohini
AU - Desai, Varsha G.
AU - Kale, Vijay M.
AU - Lee, Taewon
AU - Moland, Carrie L.
AU - Branham, William S.
AU - New, Lee S.
AU - Chan, Eric C.Y.
AU - Younis, Husam
AU - Boelsterli, Urs A.
T1 - Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/07/15/
VL - 238
IS - 2
M3 - Article
SP - 150
EP - 159
SN - 0041008X
AB - Abstract: Flutamide, a widely used nonsteroidal anti-androgen, but not its bioisostere bicalutamide, has been associated with idiosyncratic drug-induced liver injury. Although the susceptibility factors are unknown, mitochondrial injury has emerged as a putative hazard of flutamide. To explore the role of mitochondrial sensitization in flutamide hepatotoxicity, we determined the effects of superimposed drug stress in a murine model of underlying mitochondrial abnormalities. Male wild-type or heterozygous Sod2+/− mice were injected intraperitoneously with flutamide (0, 30 or 100 mg/kg/day) for 28 days. A kinetic pilot study revealed that flutamide (100 mg/kg/day) caused approximately 10-fold greater exposure than the reported therapeutic mean plasma levels. Mutant (5/10), but not wild-type, mice in the high-dose group exhibited small foci of hepatocellular necrosis and an increased number of apoptotic hepatocytes. Hepatic GSSG/GSH, protein carbonyl levels, and serum lactate levels were significantly increased, suggesting oxidant stress and mitochondrial dysfunction. Measurement of mitochondrial superoxide in cultured hepatocytes demonstrated that mitochondria were a significant source of flutamide-enhanced oxidant stress. Indeed, mitochondria isolated from flutamide-treated Sod2+/− mice exhibited decreased aconitase activity as compared to vehicle controls. A transcriptomics analysis using MitoChips revealed that flutamide-treated Sod2+/− mice exhibited a selective decrease in the expression of all complexes I and III subunits encoded by mitochondrial DNA. In contrast, Sod2+/− mice receiving bicalutamide (50 mg/kg/day) did not reveal any hepatic changes. These results are compatible with our concept that flutamide targets hepatic mitochondria and exerts oxidant stress that can lead to overt hepatic injury in the presence of an underlying mitochondrial abnormality. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIAL pathology
KW - FLUTAMIDE
KW - LIVER -- Wounds & injuries
KW - OXIDATIVE stress
KW - IDIOSYNCRATIC drug reactions
KW - DRUGS -- Toxicology
KW - HEPATOTOXICOLOGY
KW - MICE as laboratory animals
KW - alanine aminotransferase ( ALT )
KW - Bicalutamide
KW - bicalutamide ( BIC )
KW - drug-induced liver injury ( DILI )
KW - Drug-induced liver injury (DILI)
KW - Flutamide
KW - flutamide ( FLU )
KW - Hepatotoxicity
KW - Idiosyncratic drug toxicity
KW - Mitochondria
KW - oxidative phosphorylation ( OXPHOS )
KW - reactive oxygen species ( ROS )
KW - Sod2+/− mice
KW - Superoxide dismutase
KW - superoxide dismutase-2 (Mn-SOD) ( SOD2 )
KW - terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling ( TUNEL )
N1 - Accession Number: 42100265; Kashimshetty, Rohini 1 Desai, Varsha G. 2 Kale, Vijay M. 1 Lee, Taewon 3 Moland, Carrie L. 2 Branham, William S. 2 New, Lee S. 4 Chan, Eric C.Y. 4 Younis, Husam 5 Boelsterli, Urs A. 1; Email Address: urs.boelsterli@uconn.edu; Affiliation: 1: University of Connecticut School of Pharmacy, Department of Pharmaceutical Sciences, Storrs, CT, 06269 USA 2: Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079 USA 3: Korea University, Department of Information and Mathematics, Jochiwon, 339-700 Korea 4: National University of Singapore, Department of Pharmacy, 117543 Singapore 5: Pfizer Global Research and Development, San Diego, CA, 92121 USA; Source Info: Jul2009, Vol. 238 Issue 2, p150; Subject Term: MITOCHONDRIAL pathology; Subject Term: FLUTAMIDE; Subject Term: LIVER -- Wounds & injuries; Subject Term: OXIDATIVE stress; Subject Term: IDIOSYNCRATIC drug reactions; Subject Term: DRUGS -- Toxicology; Subject Term: HEPATOTOXICOLOGY; Subject Term: MICE as laboratory animals; Author-Supplied Keyword: alanine aminotransferase ( ALT ); Author-Supplied Keyword: Bicalutamide; Author-Supplied Keyword: bicalutamide ( BIC ); Author-Supplied Keyword: drug-induced liver injury ( DILI ); Author-Supplied Keyword: Drug-induced liver injury (DILI); Author-Supplied Keyword: Flutamide; Author-Supplied Keyword: flutamide ( FLU ); Author-Supplied Keyword: Hepatotoxicity; Author-Supplied Keyword: Idiosyncratic drug toxicity; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: oxidative phosphorylation ( OXPHOS ); Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: Sod2+/− mice; Author-Supplied Keyword: Superoxide dismutase; Author-Supplied Keyword: superoxide dismutase-2 (Mn-SOD) ( SOD2 ); Author-Supplied Keyword: terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling ( TUNEL ); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2009.05.007
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sun, Ronggai
AU - Skeiky, Yasir A.W.
AU - Izzo, Angelo
AU - Dheenadhayalan, Veerabadran
AU - Imam, Zakaria
AU - Penn, Erica
AU - Stagliano, Katherine
AU - Haddock, Scott
AU - Mueller, Stefanie
AU - Fulkerson, John
AU - Scanga, Charles
AU - Grover, Ajay
AU - Derrick, Steven C.
AU - Morris, Sheldon
AU - Hone, David M.
AU - Horwitz, Marcus A.
AU - Kaufmann, Stefan H.E.
AU - Sadoff, Jerald C.
T1 - Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis
JO - Vaccine
JF - Vaccine
Y1 - 2009/07/16/
VL - 27
IS - 33
M3 - Article
SP - 4412
EP - 4423
SN - 0264410X
AB - Abstract: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has infected approximately two billion individuals worldwide with approximately 9.2 million new cases and 1.6 million deaths annually. Current efforts are focused on making better BCG priming vaccines designed to induce a comprehensive and balanced immunity followed by booster(s) targeting a specific set of relevant antigens in common with the BCG prime. We describe the generation and immunological characterization of recombinant BCG strains with properties associated with lysis of the endosome compartment and over-expression of key Mtb antigens. The endosome lysis strain, a derivative of BCG SSI-1331 (BCG1331) expresses a mutant form of perfringolysin O (PfoAG137Q), a cytolysin normally secreted by Clostridium perfringens. Integration of the PfoAG137Q gene into the BCG genome was accomplished using an allelic exchange plasmid to replace ureC with pfoA G137Q under the control of the Ag85B promoter. The resultant BCG construct, designated AERAS-401 (BCG1331 ΔureC::ΩpfoA G137Q) secreted biologically active Pfo, was well tolerated with a good safety profile in immunocompromised SCID mice. A second rBCG strain, designated AFRO-1, was generated by incorporating an expression plasmid encoding three mycobacterial antigens, Ag85A, Ag85B and TB10.4, into AERAS-401. Compared to the parental BCG strain, vaccination of mice and guinea pigs with AFRO-1 resulted in enhanced immune responses. Mice vaccinated with AFRO-1 and challenged with the hypervirulent Mtb strain HN878 also survived longer than mice vaccinated with the parental BCG. Thus, we have generated improved rBCG vaccine candidates that address many of the shortcomings of the currently licensed BCG vaccine strains. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacterial toxins
KW - Bacterial antigens
KW - Immunology
KW - BCG vaccination
KW - Gene expression
KW - Drugs -- Safety measures
KW - Mycobacterium tuberculosis
KW - Mice as laboratory animals
KW - Ad35
KW - Antigen over-expression
KW - Endosome lysis
KW - Prime-boost
KW - Protection
KW - Recombinant BCG
KW - T-cell
KW - Tuberculosis
KW - Vaccination
N1 - Accession Number: 43035856; Sun, Ronggai 1; Skeiky, Yasir A.W. 1; Email Address: yskeiky@aeras.org; Izzo, Angelo 2; Dheenadhayalan, Veerabadran 1; Imam, Zakaria 1; Penn, Erica 1; Stagliano, Katherine 1; Haddock, Scott 1; Mueller, Stefanie 1; Fulkerson, John 1; Scanga, Charles 1; Grover, Ajay 2; Derrick, Steven C. 3; Morris, Sheldon 3; Hone, David M. 1; Horwitz, Marcus A. 4; Kaufmann, Stefan H.E. 5; Sadoff, Jerald C. 1; Affiliations: 1: Aeras Global TB Vaccine Foundation, 1405 Research Blvd., Rockville, MD 20850, USA; 2: Colorado State University, 1682 Campus Delivery, Fort Collins, CO 80523, USA; 3: Center for Biologics Evaluation and Research, U.S. FDA, Bethesda, MD 20892, United States; 4: UCLA School of Medicine, University of California, Los Angeles, CA 90095, United States; 5: Max Planck Institute for Infection Biology, Berlin, Germany; Issue Info: Jul2009, Vol. 27 Issue 33, p4412; Thesaurus Term: Bacterial toxins; Thesaurus Term: Bacterial antigens; Thesaurus Term: Immunology; Subject Term: BCG vaccination; Subject Term: Gene expression; Subject Term: Drugs -- Safety measures; Subject Term: Mycobacterium tuberculosis; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: Ad35; Author-Supplied Keyword: Antigen over-expression; Author-Supplied Keyword: Endosome lysis; Author-Supplied Keyword: Prime-boost; Author-Supplied Keyword: Protection; Author-Supplied Keyword: Recombinant BCG; Author-Supplied Keyword: T-cell; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccination; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.05.048
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Parreiras, P.M.
AU - Sirota, L.A.
AU - Wagner, L.D.
AU - Menzies, S.L.
AU - Arciniega, J.L.
T1 - Comparability of ELISA and toxin neutralization to measure immunogenicity of Protective Antigen in mice, as part of a potency test for anthrax vaccines
JO - Vaccine
JF - Vaccine
Y1 - 2009/07/16/
VL - 27
IS - 33
M3 - Article
SP - 4537
EP - 4542
SN - 0264410X
AB - Abstract: Complexities of lethal challenge models have prompted the investigation of immunogenicity assays as potency tests of anthrax vaccines. An ELISA and a lethal toxin neutralization assay (TNA) were used to measure antibody response to Protective Antigen (PA) in mice immunized once with either a commercial or a recombinant PA (rPA) vaccine formulated in-house. Even though ELISA and TNA results showed correlation, ELISA results may not be able to accurately predict TNA results in this single immunization model. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Toxins
KW - VACCINATION
KW - Bacterial diseases
KW - Immunogenetics
KW - Mice as laboratory animals
KW - Anthrax
KW - Bacterial vaccines
KW - Anthrax
KW - Potency
KW - Vaccine
N1 - Accession Number: 43035873; Parreiras, P.M. 1,2; Sirota, L.A. 2; Wagner, L.D. 2; Menzies, S.L. 2; Arciniega, J.L. 2; Email Address: juan.arciniega@fda.hhs.gov; Affiliations: 1: Oswaldo Cruz Foundation, Research Center Rene Rachou, Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil; 2: Center for Biologics Evaluation and Research, US FDA, CBER/DBPAP [HFM-443], 1401 Rockville Pike, Rockville, MD 20852, USA; Issue Info: Jul2009, Vol. 27 Issue 33, p4537; Thesaurus Term: Toxins; Thesaurus Term: VACCINATION; Thesaurus Term: Bacterial diseases; Subject Term: Immunogenetics; Subject Term: Mice as laboratory animals; Subject Term: Anthrax; Subject Term: Bacterial vaccines; Author-Supplied Keyword: Anthrax; Author-Supplied Keyword: Potency; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.05.045
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tareke, Eden
AU - Lyn-Cook, Beverly D.
AU - Duhart, Helen
AU - Newport, Glenn
AU - Ali, Syed
T1 - Acrylamide decreased dopamine levels and increased 3-nitrotyrosine (3-NT) levels in PC 12 cells
JO - Neuroscience Letters
JF - Neuroscience Letters
Y1 - 2009/07/17/
VL - 458
IS - 2
M3 - Article
SP - 89
EP - 92
SN - 03043940
AB - Abstract: Acrylamide is a chemical known to produce neurotoxicity in animals, as well as in humans. The mechanism of acrylamide-induced neurotoxicity is not fully known. However, recent studies have revealed that acrylamide affects the dopaminergic system. Therefore, the aim of this study was to investigate the effect of acrylamide on dopamine (DA) and the metabolites, 3,4-dihydroxy phenylacetic acid (DOPAC) and homovanillicacid (HVA), levels in Pheochromocytoma (PC 12) cells. In addition, the generation of peroxynitrite (ONOO−), measured by 3-nitrotyrosine (3-NT), was investigated as a possible mechanism in acrylamide-induced neurotoxicity. HPLC-coupled to electrochemical detection (ECD) was used to determine DA, DOPAC, HVA and 3-NT levels. Acrylamide (0.01–5mM) exposure produced a dose- and time (1–42h)-dependent decrease in DA levels. The decrease (P <0.05) in DA levels was noted at 24h after exposure to acrylamide. The study also revealed that 3-NT levels in PC 12 increased as a result of treatment with acrylamide. Thus, these data suggest that acrylamide-induced decrease in DA levels in PC 12 cells may be associated with peroxynitrite formation, measured as 3-NT levels. [Copyright &y& Elsevier]
AB - Copyright of Neuroscience Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXIC agents
KW - ACRYLAMIDE
KW - MECHANISM of action (Biochemistry)
KW - DOPAMINERGIC mechanisms
KW - HIGH performance liquid chromatography
KW - 3-Nitrotyrosine
KW - Acrylamide
KW - Dopamine
KW - PC 12 cells
N1 - Accession Number: 39784551; Tareke, Eden 1; Email Address: edunatar@hotmail.com Lyn-Cook, Beverly D. 2 Duhart, Helen 1 Newport, Glenn 1 Ali, Syed 1; Affiliation: 1: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 2: Office of Regulatory Activities, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Jul2009, Vol. 458 Issue 2, p89; Subject Term: NEUROTOXIC agents; Subject Term: ACRYLAMIDE; Subject Term: MECHANISM of action (Biochemistry); Subject Term: DOPAMINERGIC mechanisms; Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: 3-Nitrotyrosine; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: PC 12 cells; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.neulet.2009.04.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pitzer, Virginia E.
AU - Viboud, Cécile
AU - Simonsen, Lone
AU - Steiner, Claudia
AU - Panozzo, Catherine A.
AU - Alonso, Wladimir J.
AU - Miller, Mark A.
AU - Glass, Roger I.
AU - Glasser, John W.
AU - Parashar, Umesh D.
AU - Grenfell, Bryan T.
T1 - Demographic Variability, Vaccination, and the Spatiotemporal Dynamics of Rotavirus Epidemics.
JO - Science
JF - Science
Y1 - 2009/07/17/
VL - 325
IS - 5938
M3 - Article
SP - 290
EP - 294
SN - 00368075
AB - Historically, annual rotavirus activity in the United States has started in the southwest in late fall and ended in the northeast 3 months later; this trend has diminished in recent years. Traveling waves of infection or local environmental drivers cannot account for these patterns. A transmission model calibrated against epidemiological data shows that spatiotemporal variation in birth rate can explain the timing of rotavirus epidemics. The recent large-scale introduction of rotavirus vaccination provides a natural experiment to further test the impact of susceptible recruitment on disease dynamics. The model predicts a pattern of reduced and tagged epidemics postvaccination, closely matching the observed dynamics. Armed with this validated model, we explore the relative importance of direct and indirect protection, a key issue in determining the worldwide benefits of vaccination. [ABSTRACT FROM AUTHOR]
AB - Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTAVIRUS diseases
KW - DEMOGRAPHIC surveys
KW - RESEARCH
KW - VACCINATION
KW - SPATIAL analysis (Statistics)
KW - EPIDEMICS -- Research
KW - COMMUNICABLE diseases -- Transmission
KW - DISEASES -- Risk factors
KW - MATHEMATICAL models
N1 - Accession Number: 43608595; Pitzer, Virginia E. 1,2; Email Address: vep2@psu.edu Viboud, Cécile 2 Simonsen, Lone 3 Steiner, Claudia 4 Panozzo, Catherine A. 5 Alonso, Wladimir J. 2 Miller, Mark A. 2 Glass, Roger I. 2 Glasser, John W. 5 Parashar, Umesh D. 5 Grenfell, Bryan T. 1,2,6; Affiliation: 1: Center for Infectious Disease Dynamics, Pennsylvania State University, State College, PA 16801, USA 2: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA 3: School of Public Health and Health Services, George Washington University, Washington, DC 20052, USA 4: Healthcare Cost and Utilization Project, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Sciences, Rockville, MD 20850, USA 5: Epidemiology Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA 6: Department of Ecology and Evolutionary Biology and Woodrow Wilson School, Princeton University, Princeton, NJ 08544, USA; Source Info: 7/17/2009, Vol. 325 Issue 5938, p290; Subject Term: ROTAVIRUS diseases; Subject Term: DEMOGRAPHIC surveys; Subject Term: RESEARCH; Subject Term: VACCINATION; Subject Term: SPATIAL analysis (Statistics); Subject Term: EPIDEMICS -- Research; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: DISEASES -- Risk factors; Subject Term: MATHEMATICAL models; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Conway, Patrick H.
AU - Clancy, Carolyn
T1 - Comparative-Effectiveness Research — Implications of the Federal Coordinating Council's Report.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/07/23/
VL - 361
IS - 4
M3 - Editorial
SP - 328
EP - 330
SN - 00284793
AB - In this article, the authors talk about a report released by the U.S. Federal Coordinating Council concerning comparative-effectiveness research (CER) in 2009. CER aims to assist clinicians and patients to select options that will suit the needs and preferences of patients. Several agencies have been conducting CER including, but not limited to, the U.S. Department of Veterans Affairs (VA), the U.S. National Institutes of Health (NIH), and the U.S. Agency for Healthcare Research and Quality (AHRQ).
KW - PATIENTS
KW - MEDICAL personnel
KW - UNITED States
KW - UNITED States. Dept. of Veterans Affairs
KW - NATIONAL Institutes of Health (U.S.)
KW - UNITED States. Agency for Healthcare Research & Quality
N1 - Accession Number: 43408700; Conway, Patrick H. 1,2 Clancy, Carolyn 1,3; Affiliation: 1: Department of Health and Human Services, Washington, DC 2: Cincinnati Children's Hospital Medical Center, Cincinnati 3: Agency for Healthcare Research and Quality, Rockville, MD; Source Info: 7/23/2009, Vol. 361 Issue 4, p328; Subject Term: PATIENTS; Subject Term: MEDICAL personnel; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Veterans Affairs Company/Entity: NATIONAL Institutes of Health (U.S.) Company/Entity: UNITED States. Agency for Healthcare Research & Quality; NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 3p; Document Type: Editorial; Full Text Word Count: 1732
L3 - 10.1056/NEJMp0905631
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Millet, Caroline
AU - Yamashita, Motozo
AU - Heller, Mary
AU - Li-Rong Yu
AU - Veenstra, Timothy D.
AU - Ying E. Zhang
T1 - A Negative Feedback Control of Transforming Growth Factor-β Signaling by Glycogen Synthase Kinase 3-mediated Smad3 Linker Phosphorylation at Ser-204.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/07/24/
VL - 284
IS - 30
M3 - Article
SP - 19808
EP - 19816
SN - 00219258
AB - Through the action of its membrane-bound type I receptor, transforming growth factor-β (TGF-β) elicits a wide range of cellular responses that regulate cell proliferation, differentiation, and apoptosis. Many of these signaling responses are mediated by Smad proteins. As such, controlling Smad activity is crucial for proper signaling by TGF-β and its related factors. Here, we show that TGF-β induces phosphorylation at three sites in the Smad3 linker region in addition to the two C-terminal residues, and glycogen synthase kinase 3 is responsible for phosphorylation at one of these sites, namely Ser-204. Alanine substitution at Ser-204 and/or the neighboring Ser-208, the priming site for glycogen synthase kinase 3 in vivo activity, strengthened the affinity of Smad3 to CREB binding protein, suggesting that linker phosphorylation may be part of a negative feedback loop that modulates Smad3 transcriptional activity. Thus, our findings reveal a novel aspect of the Smad3 signaling mechanism that controls the final amplitude of cellular responses to TGF-β. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFORMING growth factors
KW - GLYCOGEN synthase kinase-3
KW - APOPTOSIS
KW - PHOSPHORYLATION
KW - CELL proliferation
KW - CELL differentiation
KW - ALANINE
N1 - Accession Number: 43602931; Millet, Caroline 1 Yamashita, Motozo 1 Heller, Mary 1 Li-Rong Yu 2 Veenstra, Timothy D. 3 Ying E. Zhang 1; Email Address: yingz@helix.nih.gov; Affiliation: 1: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4256 2: Center for Proteomics, Division of System Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arizona 72079 3: Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702; Source Info: 7/24/2009, Vol. 284 Issue 30, p19808; Subject Term: TRANSFORMING growth factors; Subject Term: GLYCOGEN synthase kinase-3; Subject Term: APOPTOSIS; Subject Term: PHOSPHORYLATION; Subject Term: CELL proliferation; Subject Term: CELL differentiation; Subject Term: ALANINE; Number of Pages: 9p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1074/jbc.M109.016667
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lu Sun
AU - Haun, Shirley
AU - Jones, Richard C.
AU - Edmondson, Ricky D.
AU - Machaca, Khaled
T1 - Kinase-dependent Regulation of Inositol 1 ,4,5-Trisphosphate- dependent Ca[sup2+] Release during Oocyte Maturation.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/07/24/
VL - 284
IS - 30
M3 - Article
SP - 20184
EP - 20196
SN - 00219258
AB - Fertilization induces a species-specific Ca[sup2+] transient with specialized spatial and temporal dynamics, which are essential to temporally encode egg activation events such as the block to polyspermy and resumption of meiosis. Eggs acquire the competence to produce the fertilization-specific Ca[sup2+] transient during oocyte maturation, which encompasses dramatic potentiation of inositol 1,4,5-trisphosphate (IP[sub3])-dependent Ca[sup2+] release. Here we show that increased IP[sub3] receptor (IP[sub3]R) sensitivity is initiated at the germinal vesicle breakdown stage of maturation, which correlates with maturation promoting factor (MPF) activation. Extensive phosphopeptide mapping of the IP[sub3]R resulted in ∼70% coverage and identified three residues, Thr-931, Thr-1136, and Ser-114, which are specifically phosphorylated during maturation. Phospho-specific antibody analyses show that Thr-1136 phosphorylation requires MPF activation. Activation of either MPF or the mitogen-activated protein kinase cascade independently, functionally sensitizes IP[sub3]-dependent Ca[sup2+] release. Collectively, these data argue that the kinase cascades driving meiotic maturation potentiates IP[sub3]-dependent Ca[sup2+] release, possibly trough direct phosphorylation of the IP[sub3]R. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FERTILIZATION (Biology)
KW - PHOSPHORYLATION
KW - MITOGEN-activated protein kinases
KW - MEIOSIS
KW - INOSITOL phosphates
KW - SPERM-ovum interactions
N1 - Accession Number: 43602970; Lu Sun 1 Haun, Shirley 1 Jones, Richard C. 2 Edmondson, Ricky D. 2 Machaca, Khaled 1,3; Email Address: khm2002@qatar-med.cornell.edu; Affiliation: 1: Department of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, Arkansas 72205 2: National Center for Toxicology Research, Food and Drug Administration, Jefferson, Arkansas 72079 3: Weill Cornell Medical College, Education City, P. 0. Box24 144, Qatar Foundation, Doha, Qatar; Source Info: 7/24/2009, Vol. 284 Issue 30, p20184; Subject Term: FERTILIZATION (Biology); Subject Term: PHOSPHORYLATION; Subject Term: MITOGEN-activated protein kinases; Subject Term: MEIOSIS; Subject Term: INOSITOL phosphates; Subject Term: SPERM-ovum interactions; Number of Pages: 13p; Illustrations: 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1074/jbc.M109.004515
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tournas, V.H.
AU - Uppal Memon, S.
T1 - Internal contamination and spoilage of harvested apples by patulin-producing and other toxigenic fungi
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/07/31/
VL - 133
IS - 1/2
M3 - Article
SP - 206
EP - 209
SN - 01681605
AB - Abstract: A total of 424 apple samples comprised of six varieties (Gala, Red Delicious, Golden Delicious, Fuji, Granny Smith, and Braeburn) were analyzed for internal fungal contamination. Two hundred sixteen apples were incubated intact for 2–4 weeks at room temperature. The cores of the remaining 208 apples were aseptically removed and incubated without supplemental media at room temperature for 3 weeks. After the incubation period was over, the mycological profiles of the analyzed samples were determined. Twelve per cent of the intact apples showed visible growth after 2–4 weeks of incubation at room temperature. Penicillia (including the patulin producer, Penicillium expansum) were the most frequent, found in 8% of the samples followed by Fusarium and Alternaria spp. (each found in 3% of the samples tested). The highest mould incidence was observed in the Red Delicious and Fuji and the lowest in the Granny Smith variety. A variety of microfungi including members of the toxigenic genera Alternaria, Penicillium and Fusarium were isolated from the apple cores. The predominant moulds were Alternaria, Cladosporium, Penicillium and Fusarium spp. recovered from 50, 22, 33 and 23% of the analyzed samples, respectively. Less common were Ulocladium spp., Botrytis cinerea and Aureobasidium pullulans found in less than 4% of the samples. Yeasts were found only in 2% of the samples. Apple cores from all varieties tested showed a high degree of mould contamination. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Food spoilage
KW - HARVESTING
KW - Mycotoxins
KW - Fruit -- Varieties
KW - Food -- Microbiology
KW - Effect of patulin on plants
KW - Apples
KW - Fusarium
KW - Alternaria
KW - Apples
KW - Internal contamination
KW - Toxigenic moulds
N1 - Accession Number: 42962866; Tournas, V.H. 1; Email Address: valerie.tournas@fda.hhs.gov; Uppal Memon, S. 2; Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA; 2: Joint Institute for Food Safety and Applied Nutrition/University of Maryland, College Park, MD 20740, USA; Issue Info: Jul2009, Vol. 133 Issue 1/2, p206; Thesaurus Term: Food contamination; Thesaurus Term: Food spoilage; Thesaurus Term: HARVESTING; Thesaurus Term: Mycotoxins; Thesaurus Term: Fruit -- Varieties; Thesaurus Term: Food -- Microbiology; Subject Term: Effect of patulin on plants; Subject Term: Apples; Subject Term: Fusarium; Subject Term: Alternaria; Author-Supplied Keyword: Apples; Author-Supplied Keyword: Internal contamination; Author-Supplied Keyword: Toxigenic moulds; NAICS/Industry Codes: 111331 Apple Orchards; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2009.05.025
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 2009-11706-001
AN - 2009-11706-001
AU - Urbanus, Anouk T.
AU - van de Laar, Thijs J.
AU - Stolte, Ineke G.
AU - Schinkel, Janke
AU - Heijman, Titia
AU - Coutinho, Roel A.
AU - Prins, Maria
T1 - Hepatitis C virus infections among HIV-infected men who have sex with men: An expanding epidemic.
JF - AIDS
JO - AIDS
JA - AIDS
Y1 - 2009/07/31/
VL - 23
IS - 12
SP - F1
EP - F7
CY - US
PB - Lippincott Williams & Wilkins
SN - 0269-9370
SN - 1473-5571
AD - Urbanus, Anouk T., Amsterdam Public Health Service, Cluster of Infectious Diseases, Department of Research, P.O. Box 2200, 1000 CE, Amsterdam, Netherlands
N1 - Accession Number: 2009-11706-001. PMID: 19542864 Partial author list: First Author & Affiliation: Urbanus, Anouk T.; Cluster of Infectious Diseases, Amsterdam Public Health Service, Amsterdam, Netherlands. Release Date: 20100201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: International AIDS Conference, XVIIth, 2008, Mexico City, Mexico. Conference Note: Data presented previously at the aforementioned conference and the 13th International Symposium on Viral Hepatitis and Liver Disease 2009 (ISVHLD), Washington, District of Columbia, USA. Major Descriptor: Epidemiology; Hepatitis; HIV; Male Homosexuality. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Outpatient (60). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Jul 31, 2009. Publication History: Accepted Date: May 19, 2009; Revised Date: May 4, 2009; First Submitted Date: Apr 6, 2009. Copyright Statement: Wolters Kluwer Health | Lippincott Williams & Wilkins. 2009.
AB - Background: Since 2,000 outbreaks of sexually transmitted hepatitis C Virus (HCV) infections have been reported among HIV-infected men who have sex with men (MSM). We studied the prevalence and determinants of HCV-infection among MSM attending a large sexually transmitted infection (STI) clinic in the Netherlands. Methods: In 2007–2008, 3125 attendees of the STI clinic Amsterdam, including 689 MSM, participated in an anonymous biannual cross sectional survey. Participants were interviewed and screened for HIV and HCV antibodies. Additionally, all anti-HCV positive and HIV-infected individuals were tested for HCV RNA. Using phylogenetic analysis, HCV strains of the STI clinic attendees were compared with those isolated from MSM with acute HCV in 2000–2007. Determinants of HCV-infection were analyzed using logistic regression. Results: Two of 532 (0.4%) HIV-negative MSM and 28 of 157 (17.8%) HIV-positive MSM were infected with HCV. Over the study period, HCV prevalence among HIV infected MSM increased (14.6%–20.9%). Seven of 28 (25.0%) HIV/HCV coinfected MSM had acute HCV infection. Only five of 28 (17.9%) HIV/HCV coinfected MSM ever injected drugs (IDU). HIV-infection, IDU, fisting and gamma hydroxy butyrate (GHB)-use were significantly associated with HCV-infection. Phylogenetic analyses revealed a high degree of MSM-specific clustering. Conclusion: We found a high and increasing HCV prevalence in HIV-infected MSM. Though not statistically significant, this trend, and the relatively large proportion of acute infections suggest ongoing transmission of HCV in HIV-positive MSM. Regardless of IDU, rough sexual techniques and use of recreational drugs were associated with HCV-infection; phylogenetic analysis supported sexual transmission. Targeted prevention, like raising awareness and routine testing, is needed to stop the further spread among HIV-infected MSM, and to prevent possible spillover to HIV-negative MSM. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hepatitis C virus infections
KW - HIV-infected men
KW - men who have sex with men
KW - prevalence
KW - 2009
KW - Epidemiology
KW - Hepatitis
KW - HIV
KW - Male Homosexuality
KW - 2009
DO - 10.1097/QAD.0b013e32832e5631
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11706-001&site=ehost-live&scope=site
UR - aurbanus@ggd.amsterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Mackey, Ann Corken
AU - Green, Lanh
AU - Amand, Keith St
AU - Avigan, Mark
T1 - Sodium Phosphate Tablets and Acute Phosphate Nephropathy.
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
Y1 - 2009/08//
VL - 104
IS - 8
M3 - Article
SP - 1903
EP - 1906
SN - 00029270
AB - The article presents a study that evaluates the relationship between sodium phosphate tablets (SPT) and acute phosphate nephropathy. It was conducted by evaluating 10 cases with acute phosphate nephropathy associated with renal failure that are examined after the administration of sodium phosphate tablets. Results of the study conclude that clinicians should be aware when prescribing SPT.
KW - KIDNEY diseases
KW - SODIUM phosphates
KW - ACUTE kidney failure
KW - DRUG utilization
KW - DRUGS -- Analysis
N1 - Accession Number: 43566823; Mackey, Ann Corken 1 Green, Lanh 1 Amand, Keith St 1 Avigan, Mark 1; Affiliation: 1: Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Aug2009, Vol. 104 Issue 8, p1903; Subject Term: KIDNEY diseases; Subject Term: SODIUM phosphates; Subject Term: ACUTE kidney failure; Subject Term: DRUG utilization; Subject Term: DRUGS -- Analysis; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 4p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1038/ajg.2009.342
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43566823&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gupta, Abhay
AU - Ciavarella, Anthony B.
AU - Rothman, Barry
AU - Faustino, Patrick J.
AU - Khan, Mansoor A.
T1 - Stability of gabapentin 300-mg capsules repackaged in unit dose containers.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2009/08//8/1/2009
VL - 66
IS - 15
M3 - Article
SP - 1376
EP - 1380
PB - American Society of Health System Pharmacists
SN - 10792082
AB - Purpose. The stability of a gabapentin 300-mg capsule product in the original bulk containers and repackaged in unit dose blister strips was studied. Methods. Both products were stored for one year under long-term storage conditions (25 °C and 60% relative humidity [RH]) and for three months under accelerated storage conditions (40 °C and 75% RH) and tested for weight change, potency, and dissolution using validated analytical method. Results. The capsules in the original containers showed no change in weight during the study period. However, the repackaged drug product stored under long-term storage conditions and under accelerated storage conditions showed significant weight increases (p < 0.001) during the study period. No significant differences in potency between the original and repackaged drug products were detected. Potency exceeded 97% for the products stored under the long-term storage conditions and exceeded 95% for the products stored under the accelerated storage conditions. At 13 weeks, samples from the original container and the blister strips stored under the accelerated storage conditions showed quantitative levels of the lactam degradation product; however, these levels were within acceptable limits. No other difference was observed between the original and the repackaged drug products, and both products remained stable throughout the study period. Conclusion. Gabapentin 300-mg capsules in the original containers and repackaged in blister strips were stable up to one year under long-term storage conditions and up to three months under accelerated storage conditions. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Health-System Pharmacy is the property of American Society of Health System Pharmacists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Packaging
KW - MANUFACTURING processes
KW - MEDICAL supplies
KW - PHYSICAL distribution of goods
KW - CONTAINERS
KW - Anticonvulsants
KW - Capsules
KW - Dissolution
KW - Drug distribution systems
KW - Gabapentin
KW - Moisture
KW - Packaging
KW - Stability
KW - Storage
KW - Temperature
KW - Weight
N1 - Accession Number: 43832579; Gupta, Abhay 1 Ciavarella, Anthony B. 1 Rothman, Barry Faustino, Patrick J. 2 Khan, Mansoor A. 2; Email Address: mansoor.khan@fda.hhs.gov; Affiliation: 1: Division of Product Quality Research (DPQR), Office of Testing and Research (OTR), Office of Pharmaceutical Science (OPS); Silver Spring 2: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 8/1/2009, Vol. 66 Issue 15, p1376; Subject Term: DRUGS -- Packaging; Subject Term: MANUFACTURING processes; Subject Term: MEDICAL supplies; Subject Term: PHYSICAL distribution of goods; Subject Term: CONTAINERS; Author-Supplied Keyword: Anticonvulsants; Author-Supplied Keyword: Capsules; Author-Supplied Keyword: Dissolution; Author-Supplied Keyword: Drug distribution systems; Author-Supplied Keyword: Gabapentin; Author-Supplied Keyword: Moisture; Author-Supplied Keyword: Packaging; Author-Supplied Keyword: Stability; Author-Supplied Keyword: Storage; Author-Supplied Keyword: Temperature; Author-Supplied Keyword: Weight; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; Number of Pages: 5p; Illustrations: 1 Diagram, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.2146/ajhp080236
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43832579&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105406705
T1 - Evaluation of institutional practices for prevention of phlebotomy-associated percutaneous injuries in hospital settings.
AU - Knapp MB
AU - Grytdal SP
AU - Chiarello LA
AU - Sinkowitz-Cochran RL
AU - Zombeck A
AU - Klein C
AU - Warden B
AU - Lyden J
AU - Pearson ML
Y1 - 2009/08//
N1 - Accession Number: 105406705. Language: English. Entry Date: 20091002. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. NLM UID: 8004854.
KW - Organizational Policies
KW - Patient Safety
KW - Phlebotomy -- Adverse Effects
KW - Audiorecording
KW - Coding
KW - Convenience Sample
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Focus Groups
KW - Interviews
KW - Multicenter Studies
KW - Nonexperimental Studies
KW - Nonprobability Sample
KW - Qualitative Studies
KW - United States
KW - Human
SP - 490
EP - 494
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 37
IS - 6
CY - New York, New York
PB - Elsevier Science
AB - BACKGROUND: To reduce the incidence of phlebotomy-related percutaneous injuries (PIs), factors that contribute to these injuries must be identified. This study examined institutional phlebotomy practices, policies, perceptions, and culture to identify facilitators and barriers that appear to have the greatest impact in preventing injuries. METHODS: During site visits at study hospitals, observational data were collected during the performance of phlebotomy. In addition, interviews and focus groups were conducted with hospital personnel involved in phlebotomy procedures. RESULTS: Nine hospitals participated in the study. A total of 126 phlebotomy procedures were observed. Health care personnel chose devices with safety features for the majority of observed procedures (n = 122, 97%). Recommended phlebotomy practices for handling needles after use were observed in 42% to 92% of procedures. Adherence varied by type of device, occupation, and facility PI rate. In the 23 interviews and 9 focus groups, participants identified factors that facilitated PI prevention such as the availability and use of devices with safety mechanisms, adherence to recommended safe needle-handling practices, and institutional phlebotomy training. CONCLUSION: The quantitative and qualitative data indicate that a wide array of factors can affect phlebotomy-related practices and perceptions. Prevention of PIs may require comprehensive, multifaceted intervention efforts to improve the safety culture and reduce PIs and exposure to bloodborne pathogens in health care facilities.
SN - 0196-6553
AD - Prevention and Evaluation Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA.
U2 - PMID: 19188001.
DO - 10.1016/j.ajic.2008.06.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105406705&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105390933
T1 - Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States.
AU - Kuempel ED
AU - Wheeler MW
AU - Smith RJ
AU - Vallyathan V
AU - Green FH
Y1 - 2009/08//
N1 - Accession Number: 105390933. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Critical Care. NLM UID: 9421642.
KW - Dust
KW - Emphysema -- Etiology
KW - Mining
KW - Occupational Diseases -- Etiology
KW - Passive Smoking -- Adverse Effects
KW - Smoking
KW - Aged
KW - Autopsy
KW - Emphysema -- Mortality
KW - Emphysema -- Pathology
KW - Female
KW - Male
KW - Middle Age
KW - Occupational Diseases -- Mortality
KW - Occupational Diseases -- Pathology
KW - Severity of Illness Indices
KW - Survival -- Trends
KW - United States
KW - Human
SP - 257
EP - 264
JO - American Journal of Respiratory & Critical Care Medicine
JF - American Journal of Respiratory & Critical Care Medicine
JA - AM J RESPIR CRIT CARE MED
VL - 180
IS - 3
CY - New York, New York
PB - American Thoracic Society
AB - RATIONALE: Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated. OBJECTIVES: To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity. METHODS: The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models. MEASUREMENTS AND MAIN RESULTS: Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort. CONCLUSIONS: Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study.
SN - 1073-449X
AD - National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226-1998, USA. ekuempel@cdc.gov
U2 - PMID: 19423717.
DO - 10.1164/rccm.200806-840OC
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105390933&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ison, M. G.
AU - Hager, J.
AU - Blumberg, E.
AU - Burdick, J.
AU - Carney, K.
AU - Cutler, J.
AU - DiMaio, J. M.
AU - Hasz, R.
AU - Kuehnert, M. J.
AU - Ortiz-Rios, E.
AU - Teperman, L.
AU - Nalesnik, M.
T1 - Donor-Derived Disease Transmission Events in the United States: Data Reviewed by the OPTN/UNOS Disease Transmission Advisory Committee.
JO - American Journal of Transplantation
JF - American Journal of Transplantation
Y1 - 2009/08//
VL - 9
IS - 8
M3 - Article
SP - 1929
EP - 1935
PB - Wiley-Blackwell
SN - 16006135
AB - Donor-derived disease transmission is increasingly recognized as a source of morbidity and mortality among transplant recipients. Policy 4.7 of the Organ Procurement and Transplantation Network (OPTN) currently requires reporting of donor-derived events. All potential donor-derived transmission events (PDDTE) reported to OPTN/UNOS were reviewed by the Disease Transmission Advisory Committee (DTAC). Summary data from January 1, 2005–December 31, 2007, were prepared for presentation. Reports of PDDTE have increased from 7 in 2005, the first full year data were collected, to 60 in 2006 and to 97 in 2007. More detailed information is available for 2007; a classification system for determining likelihood of donor-derived transmission was utilized. In 2007, there were four proven and one possible donor-derived malignancy transmissions and four proven, two probable and six possible donor-derived infectious diseases transmissions. There were nine reported recipient deaths attributable to proven donor transmissions events arising from eight donors during 2007. Although recognized transmission events resulted in significant morbidity and mortality, transmission was reported in only 0.96% of deceased donor donations overall. Improved reporting, through enhanced recognition and communication, will be critical to better estimate the transmission risk of infection and malignancy through organ transplantation. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSPLANTATION of organs, tissues, etc.
KW - SURGERY -- Risk factors
KW - COMMUNICABLE diseases -- Transmission
KW - CANCER
KW - ORGAN donors
KW - Donor risk
KW - donor-to-host transmission
KW - infectious diseases
KW - malignancy
N1 - Accession Number: 43227466; Ison, M. G. 1; Email Address: mgison@northwestern.edu Hager, J. 2 Blumberg, E. 3 Burdick, J. 4 Carney, K. 5 Cutler, J. 6 DiMaio, J. M. 7 Hasz, R. 8 Kuehnert, M. J. 9 Ortiz-Rios, E. 10 Teperman, L. 11 Nalesnik, M. 12; Affiliation: 1: Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL 2: United Network for Organ Sharing (UNOS), Richmond, VA 3: Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 4: Health Resources and Services Administration (HRSA), US Department of Health and Human Services (HHS), Rockville, MD 5: Department of Lung Transplantation, University of Pennsylvania, Philadelphia, PA 6: Southwest Transplant Alliance, Dallas TX 7: Department of Cardiothoracic Surgery, UT Southwestern, Dallas, TX 8: Gift of Life Donor Program, Philadelphia, PA 9: Centers for Disease Control and Prevention (CDC), Office of Blood, Organ, and Other Tissue Safety Atlanta, GA 10: HRSA, HHS Rockville, MD 11: Department of Transplantation, New York University, New York, NY 12: Department of Pathology, University of Pittsburgh, Pittsburgh, PA; Source Info: Aug2009, Vol. 9 Issue 8, p1929; Subject Term: TRANSPLANTATION of organs, tissues, etc.; Subject Term: SURGERY -- Risk factors; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: CANCER; Subject Term: ORGAN donors; Author-Supplied Keyword: Donor risk; Author-Supplied Keyword: donor-to-host transmission; Author-Supplied Keyword: infectious diseases; Author-Supplied Keyword: malignancy; Number of Pages: 7p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1111/j.1600-6143.2009.02700.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43227466&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
AU - Carman, Robert J.
T1 - Characterization of an ATP-binding cassette from Clostridium perfringens with homology to an ABC transporter from Clostridium hathewayi
JO - Anaerobe
JF - Anaerobe
Y1 - 2009/08//
VL - 15
IS - 4
M3 - Article
SP - 116
EP - 121
SN - 10759964
AB - Abstract: A ciprofloxacin-resistant mutant of Clostridium perfringens, strain VPI-C, which had stable mutations in the topoisomerase genes, accumulated less norfloxacin and ethidium bromide than the wild type, strain VPI. Efflux pump inhibitors both increased the accumulation of ethidium bromide by cells of the mutant and enhanced their sensitivity to this toxic dye. Cloning a gene, which codes for a putative ABC transporter protein (NP_562422) of 527 amino acids, from the mutant strain VPI-C into the wild-type strain VPI not only reduced the accumulation of ethidium bromide by the recombinant strain but also reduced its sensitivity to norfloxacin and ciprofloxacin. Efflux pump inhibitors decreased the rate at which ethidium bromide was removed from the cells of the recombinant strain. It appears that the putative ABC transporter protein (NP_562422) may contribute to extrusion of drugs from C. perfringens. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ATP-binding cassette transporters
KW - CLOSTRIDIUM perfringens
KW - DRUG resistance in microorganisms
KW - HOMOLOGY (Biology)
KW - DNA topoisomerases
KW - MUTATION (Biology)
KW - BROMIDES
KW - BIOACCUMULATION
KW - ABC transporter
KW - Clostridium perfringens
KW - Drug resistance
N1 - Accession Number: 43531240; Rafii, Fatemeh 1; Email Address: fatemeh.rafii@fda.hhs.gov Park, Miseon 1 Carman, Robert J. 2; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Tech Lab, VPI Research Park, Blacksburg, VA 24060, USA; Source Info: Aug2009, Vol. 15 Issue 4, p116; Subject Term: ATP-binding cassette transporters; Subject Term: CLOSTRIDIUM perfringens; Subject Term: DRUG resistance in microorganisms; Subject Term: HOMOLOGY (Biology); Subject Term: DNA topoisomerases; Subject Term: MUTATION (Biology); Subject Term: BROMIDES; Subject Term: BIOACCUMULATION; Author-Supplied Keyword: ABC transporter; Author-Supplied Keyword: Clostridium perfringens; Author-Supplied Keyword: Drug resistance; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.anaerobe.2009.01.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43531240&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McDOWELL, THOMAS W.
AU - MARCOTTE, PIERRE
AU - WARREN, CRISTOPHER
AU - WELCOME, DANIEL E.
AU - DONG, REN G.
T1 - Comparing Three Methods for Evaluating Impact Wrench Vibration Emissions.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/08//
VL - 53
IS - 6
M3 - Article
SP - 617
EP - 626
SN - 00034878
AB - To provide a means for comparing impact wrenches and similar tools, the international standard ISO 8662-7 prescribes a method for measuring the vibrations at the handles of tools during their operations against a cotton–phenolic braking device. To improve the standard, alternative loading mechanisms have been proposed; one device comprises aluminum blocks with friction brake linings, while another features plate-mounted bolts to provide the tool load. The objective of this study was to evaluate these three loading methods so that tool evaluators can select appropriate loading devices in order to obtain results that can be applied to their specific workplace operations. Six experienced tool operators used five tool models to evaluate the loading mechanisms. The results of this study indicate that different loads can yield different tool comparison results. However, any of the three devices appears to be adequate for initial tool screenings. On the other hand, vibration emissions measured in the laboratory are unlikely to be fully representative of those in the workplace. Therefore, for final tool selections and for reliably assessing workplace vibration exposures, vibration measurements should be collected under actual working conditions. Evaluators need to use appropriate numbers of tools and tool operators in their assessments; recommendations are provided. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WRENCHES
KW - VIBRATION (Mechanics)
KW - WORK-related injuries
KW - VIBRATION syndrome
KW - WORK environment
KW - BRAKES
KW - hand-transmitted vibration
KW - HAVS
KW - impact wrench
KW - nut runner
KW - threaded fastener
N1 - Accession Number: 44393351; McDOWELL, THOMAS W. 1; Email Address: TMcDowell@cdc.gov MARCOTTE, PIERRE 2 WARREN, CRISTOPHER 1 WELCOME, DANIEL E. 1 DONG, REN G. 1; Affiliation: 1: National Institute for Occupational Safety & Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505, USA 2: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail, 505 boul. de Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada; Source Info: Aug2009, Vol. 53 Issue 6, p617; Subject Term: WRENCHES; Subject Term: VIBRATION (Mechanics); Subject Term: WORK-related injuries; Subject Term: VIBRATION syndrome; Subject Term: WORK environment; Subject Term: BRAKES; Author-Supplied Keyword: hand-transmitted vibration; Author-Supplied Keyword: HAVS; Author-Supplied Keyword: impact wrench; Author-Supplied Keyword: nut runner; Author-Supplied Keyword: threaded fastener; NAICS/Industry Codes: 333619 Other engine and power transmission equipment manufacturing; NAICS/Industry Codes: 332216 Saw Blade and Handtool Manufacturing; NAICS/Industry Codes: 332210 Cutlery and hand tool manufacturing; Number of Pages: 10p; Illustrations: 4 Black and White Photographs, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mep035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44393351&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - STACEY, PETER
AU - KAUFFER, EDMOND
AU - MOULUT, JEAN-CLAUDE
AU - DION, CHANTAL
AU - BEAUPARLANT, MARTIN
AU - FERNANDEZ, PABLO
AU - KEY-SCHWARTZ, ROSA
AU - FRIEDE, BERND
AU - WAKE, DERRICK
T1 - An International Comparison of the Crystallinity of Calibration Materials for the Analysis of Respirable α-Quartz Using X-Ray Diffraction and a Comparison with Results from the Infrared KBr Disc Method.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/08//
VL - 53
IS - 6
M3 - Article
SP - 639
EP - 649
SN - 00034878
AB - It is important that analytical results, produced to demonstrate compliance with exposure limits are comparable, to ensure controls are monitored to similar standards. Correcting a measurement result of respirable α-quartz for the percentage of crystalline material in the calibration dust is good analytical practice and significant changes in the values assigned to calibration materials will affect the interpretation of results by an analyst or occupational hygiene professional. The reissue of the certification for the quartz reference material NIST 1878a in 2005 and differences in comparative values obtained by other work created uncertainty about the values of crystallinity assigned to national calibration dusts for α-quartz. Members of an International Organization for Standardization working group for silica measurement ISO/TC146/SC2/WG7 collaborated to investigate the comparability of results by X-ray diffraction (XRD) and to reach a consensus. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICOSIS
KW - EPIDEMIOLOGY
KW - INDUSTRIAL hygiene
KW - SILICA
KW - QUARTZ
KW - PARTICLES
KW - analysis
KW - crystallinity
KW - infrared
KW - quartz
KW - silica
KW - x-ray diffraction
N1 - Accession Number: 44393346; STACEY, PETER 1; Email Address: Peter.Stacey@hsl.gov.uk KAUFFER, EDMOND 2 MOULUT, JEAN-CLAUDE 2 DION, CHANTAL 3 BEAUPARLANT, MARTIN 3 FERNANDEZ, PABLO 4 KEY-SCHWARTZ, ROSA 5 FRIEDE, BERND 6 WAKE, DERRICK 1; Affiliation: 1: The Health and Safety Laboratory, Harpur Hill, Buxton SK17 9JN, UK 2: Institut National de Recherche et de Sécurité, Avenue de Bourgogne BP No. 27, 54501 Vandoeuvre Cedex, France 3: Institut de recherchéRobert-Sauvé en santé et en sécurité du travail, 505, Boul. De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada 4: Instituto Nacional de Silicosis, C/Dr Bellmunt S/N, 33006 Oviedo, Spain 5: National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-7, Cincinnati, OH 45226, USA 6: Elkem Materials R&D, PO Box 8126, Vaagsbygd, 4675 Kristiansand, Norway; Source Info: Aug2009, Vol. 53 Issue 6, p639; Subject Term: SILICOSIS; Subject Term: EPIDEMIOLOGY; Subject Term: INDUSTRIAL hygiene; Subject Term: SILICA; Subject Term: QUARTZ; Subject Term: PARTICLES; Author-Supplied Keyword: analysis; Author-Supplied Keyword: crystallinity; Author-Supplied Keyword: infrared; Author-Supplied Keyword: quartz; Author-Supplied Keyword: silica; Author-Supplied Keyword: x-ray diffraction; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 11p; Illustrations: 12 Charts, 5 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mep038
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44393346&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105222370
T1 - Comparing three methods for evaluating impact wrench vibration emissions.
AU - McDowell TW
AU - Marcotte P
AU - Warren C
AU - Welcome DE
AU - Dong RG
Y1 - 2009/08//
N1 - Accession Number: 105222370. Language: English. Entry Date: 20100129. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Environmental Monitoring -- Equipment and Supplies
KW - Occupational Exposure -- Analysis
KW - Vibration
KW - Environmental Monitoring -- Methods
KW - Environmental Monitoring -- Standards
KW - Equipment Safety -- Standards
KW - Hand
KW - Human
KW - Male
SP - 617
EP - 626
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 6
PB - Oxford University Press / USA
SN - 0003-4878
AD - National Institute for Occupational Safety & Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505, USA. TMcDowell@cdc.gov
U2 - PMID: 19465462.
DO - annhyg/mep035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105222370&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jia, Yiping
AU - Alayash, Abdu I.
T1 - Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin
JO - BBA - Proteins & Proteomics
JF - BBA - Proteins & Proteomics
Y1 - 2009/08//
VL - 1794
IS - 8
M3 - Article
SP - 1234
EP - 1242
SN - 15709639
AB - Abstract: Cross-linked hemoglobins (Hbs) were found to have enhanced oxidative reactions which compromise the ability of cell-free Hb to carry oxygen. Zero-link bovine Hb (ZL-HbBv), also known as OxyVita™, a large polymer held together by pseudopeptide bonds on the surface of adjacent tetramers, provides a model in which these reactions can be evaluated. The oxygen affinity of ZL-HbBv was greatly increased, whereas the oxygen binding cooperativity (n 50) as well as the regulatory responses to pH and chloride ions was diminished. Rapid mixing kinetic studies revealed faster carbon monoxide (CO) and nitric oxide (NO) binding to ZL-HbBv, consistent with a more accessible heme pocket conformation. The rate of autoxidation of ferrous ZL-HbBv was 3 folds faster than the unmodified HbBv (control) but only slightly suppressed by the presence of superoxide dismutase and catalase enzymes. The peroxide (H2O2) reaction rates of ferric ZL-HbBv and its degradation were comparable to that of the control. The rate of heme loss from ZL-HbBv to a mutant apomyoglobin (H64Y/V68F) was also very close to that of the control. Taken together, allosteric and redox reactions of this protein are altered due to heme accessibility to solvent, however, the compact tetramer to tetramer interaction of the ZL-HbBv polymer appears to restrict heme loss even in the presence of excess H2O2. [Copyright &y& Elsevier]
AB - Copyright of BBA - Proteins & Proteomics is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN crosslinking
KW - POLYMERIZATION
KW - OXYGEN -- Physiological transport
KW - OXIDATION-reduction reaction
KW - HEMOGLOBIN
KW - SUPEROXIDE dismutase
KW - CHEMICAL affinity
KW - bovine hemoglobin ( HbBv )
KW - carbon monoxide ( CO )
KW - Hemoglobin
KW - hemoglobin ( Hb )
KW - hemoglobin-based oxygen carrier ( HBOC )
KW - hydrogen peroxide ( H2O2 )
KW - nitric oxide ( NO )
KW - Oxygen affinity
KW - Rapid kinetics
KW - Stopped-flow
KW - Zero-link
KW - zero-link bovine hemoglobin ( ZL-HbBv )
N1 - Accession Number: 41585221; Jia, Yiping; Email Address: yiping.jia@fda.hhs.gov Alayash, Abdu I. 1; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), MD 20892, USA; Source Info: Aug2009, Vol. 1794 Issue 8, p1234; Subject Term: PROTEIN crosslinking; Subject Term: POLYMERIZATION; Subject Term: OXYGEN -- Physiological transport; Subject Term: OXIDATION-reduction reaction; Subject Term: HEMOGLOBIN; Subject Term: SUPEROXIDE dismutase; Subject Term: CHEMICAL affinity; Author-Supplied Keyword: bovine hemoglobin ( HbBv ); Author-Supplied Keyword: carbon monoxide ( CO ); Author-Supplied Keyword: Hemoglobin; Author-Supplied Keyword: hemoglobin ( Hb ); Author-Supplied Keyword: hemoglobin-based oxygen carrier ( HBOC ); Author-Supplied Keyword: hydrogen peroxide ( H2O2 ); Author-Supplied Keyword: nitric oxide ( NO ); Author-Supplied Keyword: Oxygen affinity; Author-Supplied Keyword: Rapid kinetics; Author-Supplied Keyword: Stopped-flow; Author-Supplied Keyword: Zero-link; Author-Supplied Keyword: zero-link bovine hemoglobin ( ZL-HbBv ); Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.bbapap.2009.04.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sheng-Fowler, Li
AU - Lewis, Andrew M.
AU - Peden, Keith
T1 - Quantitative determination of the infectivity of the proviral DNA of a retrovirus in vitro: Evaluation of methods for DNA inactivation
JO - Biologicals
JF - Biologicals
Y1 - 2009/08//
VL - 37
IS - 4
M3 - Article
SP - 259
EP - 269
SN - 10451056
AB - Abstract: All viral vaccines contain contaminating residual DNA derived from the production cell substrate. The potential risk of this DNA, particularly when derived from tumorigenic cells, has been debated for over 40 years. While the major risk has been considered to be the oncogenicity of the DNA, another potential risk is that a genome of an infectious virus is present in this DNA. Such a genome might generate an infectious agent that could establish an infection in vaccine recipients. To determine the quantity of a retroviral provirus in cellular DNA that can establish a productive infection in vitro, we developed a transfection/co-culture system capable of recovering infectious virus from 1pg of cloned HIV DNA and from 2μg of cellular DNA from HIV-infected cells. We demonstrate that infectivity can be reduced to below detectable levels either by lowering the median size of the DNA to 350 base pairs or by treatment with β-propiolactone. From the amount of reduction of infectivity, we calculate that clearance values in excess of 107 are attainable with respect to the infectivity associated with residual cell-substrate DNA. Thus, the potential risk associated with DNA can be substantially reduced by degradation or by chemical inactivation. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RETROVIRUS diseases
KW - DIAGNOSIS
KW - GENE silencing
KW - DNA
KW - BIOLOGICAL reagents
KW - MOLECULAR cloning
KW - QUANTITATIVE research
KW - DNA inactivation
KW - DNA infectivity
KW - Vaccine cell substrates
N1 - Accession Number: 43416570; Sheng-Fowler, Li 1 Lewis, Andrew M. 2 Peden, Keith 1; Email Address: keith.peden@fda.hhs.gov; Affiliation: 1: Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Research and Evaluation,Food and Drug Administration, Bethesda, MD 20892, United States 2: Laboratory of DNA Viruses, Division of Viral Products, Center for Biologics Research and Evaluation,Food and Drug Administration, Bethesda, MD 20892, United States; Source Info: Aug2009, Vol. 37 Issue 4, p259; Subject Term: RETROVIRUS diseases; Subject Term: DIAGNOSIS; Subject Term: GENE silencing; Subject Term: DNA; Subject Term: BIOLOGICAL reagents; Subject Term: MOLECULAR cloning; Subject Term: QUANTITATIVE research; Author-Supplied Keyword: DNA inactivation; Author-Supplied Keyword: DNA infectivity; Author-Supplied Keyword: Vaccine cell substrates; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.04.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ning, Yang-min
AU - Figg, William D.
AU - Dahut, William L.
T1 - Reversal of Docetaxel Resistance With Bevacizumab and Thalidomide.
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
Y1 - 2009/08//
VL - 7
IS - 2
M3 - Article
SP - E37
EP - E38
SN - 15587673
AB - Taxane resistance is a common clinical problem in the treatment of many metastatic malignancies. Observational clues or evidence of overcoming such resistance is important for developing treatments that can extend taxane activity. We report a case of the reversal of docetaxel resistance with the addition of antiangiogenic agents bevacizumab and thalidomide to docetaxel and prednisone in a patient with metastatic castration-resistant prostate cancer after PSAWG progression on docetaxel and prednisone. The patient then responded for an additional 7 months. The addition of bevacizumab and thalidomide after progression on docetaxel/prednisone might reverse docetaxel resistance. These or other antiangiogenic agents for overcoming clinical taxane resistance are candidates for further study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Genitourinary Cancer is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOCETAXEL
KW - RESEARCH
KW - BEVACIZUMAB
KW - THALIDOMIDE
KW - PREDNISONE
KW - CANCER treatment
KW - MEDICAL research
KW - THERAPEUTIC use
KW - Antiangiogenesis
KW - castration-resistant prostate cancer
KW - Castrationresistant prostate cancer
KW - Reversal of taxane resistance
N1 - Accession Number: 43793119; Ning, Yang-min 1 Figg, William D. 2 Dahut, William L. 2; Affiliation: 1: DDOP/OODP/CDER, Food and Drug Administration, Silver Spring, MD 2: Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Source Info: Aug2009, Vol. 7 Issue 2, pE37; Subject Term: DOCETAXEL; Subject Term: RESEARCH; Subject Term: BEVACIZUMAB; Subject Term: THALIDOMIDE; Subject Term: PREDNISONE; Subject Term: CANCER treatment; Subject Term: MEDICAL research; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Antiangiogenesis; Author-Supplied Keyword: castration-resistant prostate cancer; Author-Supplied Keyword: Castrationresistant prostate cancer; Author-Supplied Keyword: Reversal of taxane resistance; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.3816/CGC.2009.n.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43793119&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105327120
T1 - Reversal of docetaxel resistance with bevacizumab and thalidomide.
AU - Ning Y
AU - Figg WD
AU - Dahut WL
Y1 - 2009/08//
N1 - Accession Number: 105327120. Language: English. Entry Date: 20091023. Revision Date: 20150711. Publication Type: Journal Article; case study; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Men's Health; Oncologic Care. NLM UID: 101260955.
KW - Docetaxel -- Therapeutic Use
KW - Drug Resistance, Neoplasm
KW - Drug Therapy, Combination
KW - Neoplasm Metastasis -- Drug Therapy
KW - Prostatic Neoplasms -- Drug Therapy
KW - Thalidomide -- Therapeutic Use
KW - Aged
KW - Male
KW - Prednisone -- Therapeutic Use
SP - E37
EP - 8
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
JA - CLIN GENITOURINARY CANCER
VL - 7
IS - 2
CY - New York, New York
PB - Elsevier Science
AB - Taxane resistance is a common clinical problem in the treatment of many metastatic malignancies. Observational clues or evidence of overcoming such resistance is important for developing treatments that can extend taxane activity. We report a case of the reversal of docetaxel resistance with the addition of antiangiogenic agents bevacizumab and thalidomide to docetaxel and prednisone in a patient with metastatic castration-resistant prostate cancer after PSAWG progression on docetaxel and prednisone. The patient then responded for an additional 7 months. The addition of bevacizumab and thalidomide after progression on docetaxel/prednisone might reverse docetaxel resistance. These or other antiangiogenic agents for overcoming clinical taxane resistance are candidates for further study.
SN - 1558-7673
AD - DDOP/OODP/CDER, Food and Drug Administration, Silver Spring, MD
U2 - PMID: 19692321.
DO - 10.3816/CGC.2009.n.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105327120&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gong, Li
AU - Debruyne, Philip R.
AU - Witek, Matthew
AU - Nielsen, Karl
AU - Snook, Adam
AU - Lin, Jieru E.
AU - Bombonati, Alessandro
AU - Palazzo, Juan
AU - Schulz, Stephanie
AU - Waldman, Scott A.
T1 - Bile Acids Initiate Lineage-Addicted Gastroesophageal Tumorigenesis by Suppressing the EGF Receptor-AKT Axis.
JO - CTS: Clinical & Translational Science
JF - CTS: Clinical & Translational Science
Y1 - 2009/08//
VL - 2
IS - 4
M3 - Article
SP - 286
EP - 293
SN - 17528054
AB - While bile acids are a risk factor for tumorigenesis induced by reflux disease, the mechanisms by which they contribute to neoplasia remain undefined. Here, we reveal that in gastroesophageal junction (GEJ) cells bile acids activate a tissue-specific developmental program defining the intestinal epithelial cell phenotype characterizing GEJ metaplasia. Deoxycholic acid (DCA) inhibited phosphorylation of EGF receptors (EGFRs) suppressing the proto-oncogene AKT. Suppression of EGFRs and AKT by DCA actuated an intestine-specific cascade in which NF-κB transactivated the tissue-specifi c transcription factor CDX2. In turn, CDX2 orchestrated a lineage-specific differentiation program encompassing genes characterizing intestinal epithelial cells. Conversely, progression from metaplasia to invasive carcinoma in patients, universally associated with autonomous activation of EGFRs and/or AKT, was coupled with loss of this intestinal program. Thus, bile acids induce intestinal metaplasia at the GEJ by activating the lineage-specifi c differentiation program involving suppression of EGFR and AKT, activating the NF-κB-CDX2 axis. Induction of this axis provides the context for lineage-addicted tumorigenesis, in which autonomous activation of AKT corrupts adaptive intestinal NF-κB signaling, amplifying tumorigenic programs. [ABSTRACT FROM AUTHOR]
AB - Copyright of CTS: Clinical & Translational Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BILE acids
KW - CARCINOGENESIS
KW - DISEASES -- Causes & theories of causation
KW - GASTROESOPHAGEAL reflux
KW - ESOPHAGOGASTRIC junction
KW - bile acids
KW - CDX2
KW - deoxycholic acid
KW - EGFR phosphorylation
KW - esophageal adenocarcinoma
KW - gastric adenocarcinoma
KW - gastroesophageal junction
KW - GUCY2C
KW - intestinal metaplasia
KW - lineage-addicted tumorigenesis
KW - neoplastic transformation
KW - NF-κB
KW - NF-κB
N1 - Accession Number: 43710575; Gong, Li 1 Debruyne, Philip R. 2 Witek, Matthew 3 Nielsen, Karl 3 Snook, Adam 3 Lin, Jieru E. 3 Bombonati, Alessandro 4 Palazzo, Juan 4 Schulz, Stephanie 3 Waldman, Scott A. 3; Email Address: scott.waldman@jefferson.edu; Affiliation: 1: Division of Bioequivalence, Food and Drug Administration, Washington, DC, USA. 2: Department of Oncology, AZ Groeninge Hospital, Kortrijk, Belgium. 3: Departments of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. 4: Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Source Info: Aug2009, Vol. 2 Issue 4, p286; Subject Term: BILE acids; Subject Term: CARCINOGENESIS; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: GASTROESOPHAGEAL reflux; Subject Term: ESOPHAGOGASTRIC junction; Author-Supplied Keyword: bile acids; Author-Supplied Keyword: CDX2; Author-Supplied Keyword: deoxycholic acid; Author-Supplied Keyword: EGFR phosphorylation; Author-Supplied Keyword: esophageal adenocarcinoma; Author-Supplied Keyword: gastric adenocarcinoma; Author-Supplied Keyword: gastroesophageal junction; Author-Supplied Keyword: GUCY2C; Author-Supplied Keyword: intestinal metaplasia; Author-Supplied Keyword: lineage-addicted tumorigenesis; Author-Supplied Keyword: neoplastic transformation; Author-Supplied Keyword: NF-κB; Author-Supplied Keyword: NF-κB; Number of Pages: 8p; Illustrations: 1 Color Photograph, 6 Graphs; Document Type: Article
L3 - 10.1111/j.1752-8062.2009.00131.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Moore, Terry
AU - Smith, Anjanette
AU - Wei Ye
AU - Toler, Duckhee Y.
AU - Westenberger, Benjamin J.
AU - Lionberger, Robert
AU - Raw, Andre
AU - Yu, Lawrence
AU - Buhse, Lucinda F.
T1 - Generic omeprazole delayed-release capsules: in vitro performance evaluations.
JO - Drug Development & Industrial Pharmacy
JF - Drug Development & Industrial Pharmacy
Y1 - 2009/08//
VL - 35
IS - 8
M3 - Article
SP - 917
EP - 921
PB - Taylor & Francis Ltd
SN - 03639045
AB - Background: After the patent on omeprazole delayed-release capsules expired, Food and Drug Administration (FDA) approved several generic omeprazole delayed-release capsule applications. FDA has received some complaints concerning a lack of therapeutic effect of the generic omeprazole delayed-release capsules. Aim: To investigate the quality of five different marketed generic omeprazole delayed-release capsules. Method: The dissolution characteristics of these generic omeprazole delayed-release capsules were determined according to the United States Pharmacopeia (USP). Additional dissolution studies under simulated in vivo physiological conditions were also conducted to determine whether generic omeprazole capsules would perform similarly under these conditions. Results: The experimental data show that all the generic omeprazole delayed-release capsules met the USP standards. The in vitro dissolution of generic drugs is similar to that of the brand omeprazole product. Conclusions: There is no scientific evidence to support the claims that the generic omeprazole delayed-release capsules perform differently from the brand omeprazole product in vitro. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Development & Industrial Pharmacy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PATENTS
KW - BENZIMIDAZOLES
KW - OMEPRAZOLE
KW - GENERIC drugs
KW - UNITED States
KW - Delayed-release capsules
KW - dissolution
KW - generics
KW - omeprazole
KW - stability
N1 - Accession Number: 43448529; Moore, Terry 1; Email Address: terry.moore@fda.hhs.gov; Smith, Anjanette 1; Wei Ye 1; Toler, Duckhee Y. 1; Westenberger, Benjamin J. 1; Lionberger, Robert 2; Raw, Andre 2; Yu, Lawrence 2; Buhse, Lucinda F. 1; Affiliations: 1: Office of Testing and Research, Division of Pharmaceutical Analysis, Food and Drug Administration, St. Louis, MO, USA.; 2: Office of Generic Drugs, Food and Drug Administration, Rockville, MD, USA.; Issue Info: Aug2009, Vol. 35 Issue 8, p917; Thesaurus Term: PATENTS; Subject Term: BENZIMIDAZOLES; Subject Term: OMEPRAZOLE; Subject Term: GENERIC drugs; Subject: UNITED States; Author-Supplied Keyword: Delayed-release capsules; Author-Supplied Keyword: dissolution; Author-Supplied Keyword: generics; Author-Supplied Keyword: omeprazole; Author-Supplied Keyword: stability; Number of Pages: 5p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/03639040802698802
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Stephenson, Iain
AU - Heath, Alan
AU - Major, Diane
AU - Newman, Robert W.
AU - Hoschler, Katja
AU - Junzi, Wang
AU - Katz, Jacqueline M.
AU - Weir, Jerry P.
AU - Zambon, Maria C.
AU - Wood, John M.
T1 - Reproducibility of Serologic Assays for Influenza Virus A (H5N1).
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/08//
VL - 15
IS - 8
M3 - Article
SP - 1250
EP - 1259
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Hemagglutination-inhibition (HI) and neutralization are used to evaluate vaccines against influenza virus A (H5N1); however, poor standardization leads to interlaboratory variation of results. A candidate antibody standard (07/150) was prepared from pooled plasma of persons given clade 1 A/Vietnam/1194/2004 vaccine. To test human and sheep antiserum, 15 laboratories used HI and neutralization and reassortant A/Vietnam/1194/2004, A/turkey/Turkey/1/2005 (clade 2.2), and A/Anhui/1/2005 (clade 2.3.4) viruses. Interlaboratory variation was observed for both assays, but when titers were expressed relative to 07/150, overall percentage geometric coefficient of variation for A/Vietnam/1194/2004 was reduced from 125% to 61% for HI and from 183% to 81% for neutralization. Lack of reduced variability to clade 2 antigens suggested the need for clade-specific standards. Sheep antiserum as a standard did not reliably reduce variability. The World Health Organization has established 07/150 as an international standard for antibody to clade 1 subtype H5 and has an assigned potency of 1,000 IU/ampoule. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Neutralization (Chemistry)
KW - Agglutination of blood
KW - Influenza A virus
KW - Immunoglobulins
KW - Blood plasma
KW - World Health Organization
N1 - Accession Number: 43826847; Stephenson, Iain 1; Heath, Alan 2; Major, Diane 2; Newman, Robert W. 2; Hoschler, Katja 3; Junzi, Wang 4; Katz, Jacqueline M. 5; Weir, Jerry P. 6; Zambon, Maria C. 3; Wood, John M. 2; Affiliations: 1: University of Leicester, Leicester, UK; 2: National Institute for Biological Standards and Controls, Potters Bar, UK; 3: Health Protection Agency, Colindale, UK; 4: National Institute for the Control of Pharmaceutical and Biological Products, Beijing, People's Republic of China; 5: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 6: Food and Drug Administration, Rockville, Maryland, USA; Issue Info: Aug2009, Vol. 15 Issue 8, p1250; Thesaurus Term: Neutralization (Chemistry); Subject Term: Agglutination of blood; Subject Term: Influenza A virus; Subject Term: Immunoglobulins; Subject Term: Blood plasma ; Company/Entity: World Health Organization; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 10p; Illustrations: 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.3201/eid1508.081754
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cummings, Kristin J.
AU - Stefaniak, Aleksandr B.
AU - Virji, M. Abbas
AU - Kreiss, Kathleen
T1 - A Reconsideration of Acute Beryllium Disease.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009/08//
VL - 117
IS - 8
M3 - Article
SP - 1250
EP - 1256
PB - Superintendent of Documents
SN - 00916765
AB - Context: Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the pathophysiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers. Case Presentation: Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 μg/m3, and most were < 10 μg/m3, lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD. Discussion: Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved. Relevance to Practice: ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Hazardous substance exposure
KW - Heavy metals -- Toxicology
KW - Nitric oxide
KW - Lung diseases -- Diagnosis
KW - Alveolar process -- Diseases
KW - Pneumonia
KW - Chest pain
KW - Metal products
KW - acute
KW - beryllium
KW - beryllium disease
KW - granuloma
KW - hypersensitivity
KW - immune sensitization
KW - pneumonitis
N1 - Accession Number: 44199038; Cummings, Kristin J. 1; Email Address: cvx5@cdc.gov; Stefaniak, Aleksandr B. 1; Virji, M. Abbas 1; Kreiss, Kathleen 1; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Issue Info: Aug2009, Vol. 117 Issue 8, p1250; Thesaurus Term: Beryllium; Thesaurus Term: Hazardous substance exposure; Thesaurus Term: Heavy metals -- Toxicology; Thesaurus Term: Nitric oxide; Subject Term: Lung diseases -- Diagnosis; Subject Term: Alveolar process -- Diseases; Subject Term: Pneumonia; Subject Term: Chest pain; Subject Term: Metal products; Author-Supplied Keyword: acute; Author-Supplied Keyword: beryllium; Author-Supplied Keyword: beryllium disease; Author-Supplied Keyword: granuloma; Author-Supplied Keyword: hypersensitivity; Author-Supplied Keyword: immune sensitization; Author-Supplied Keyword: pneumonitis; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 332999 All Other Miscellaneous Fabricated Metal Product Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 7p; Illustrations: 1 Black and White Photograph, 2 Graphs; Document Type: Article
L3 - 10.1289/ehp.0800455
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44199038&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105433983
T1 - A reconsideration of acute Beryllium disease.
AU - Cummings KJ
AU - Stefaniak AB
AU - Virji MA
AU - Kreiss K
Y1 - 2009/08//
N1 - Accession Number: 105433983. Language: English. Entry Date: 20091023. Revision Date: 20150711. Publication Type: Journal Article; case study; diagnostic images; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 0330411.
KW - Beryllium -- Adverse Effects
KW - Occupational Exposure
KW - Pneumoconiosis -- Physiopathology
KW - Acute Disease
KW - Adult
KW - Chronic Disease
KW - Industry
KW - Male
KW - Pneumoconiosis -- Diagnosis
KW - Pneumoconiosis -- Radiography
KW - Radiography, Thoracic
KW - Respiratory Function Tests
SP - 1250
EP - 1256
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
JA - ENVIRON HEALTH PERSPECT
VL - 117
IS - 8
CY - Washington, District of Columbia
PB - Superintendent of Documents
AB - CONTEXT: Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the patho physiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers. CASE PRESENTATION: Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 microg/m(3), and most were < 10 microg/m(3), lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD. DISCUSSION: Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved. RELEVANCE TO PRACTICE: ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD.
SN - 0091-6765
AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov
U2 - PMID: 19672405.
DO - 10.1289/ehp.0800455
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105433983&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - RPRT
AU - Bányai, K.
AU - Kisfali, P.
AU - Bogdán, Á.
AU - Martella, V.
AU - Melegh, B.
AU - Erdman, D.
AU - Szűcs, G.
T1 - Adenovirus gastroenteritis in Hungary, 2003–2006.
JO - European Journal of Clinical Microbiology & Infectious Diseases
JF - European Journal of Clinical Microbiology & Infectious Diseases
Y1 - 2009/08//
VL - 28
IS - 8
M3 - Report
SP - 997
EP - 999
SN - 09349723
AB - The incidence and type distribution of enteric human adenoviruses (HAds) among diarrheic children in south-western Hungary was investigated from 2003 through 2006. Laboratory studies were conducted using commercial antigen detection tests (latex agglutination or immunochromatography), polymerase chain reaction (PCR) amplification, single-strand conformation polymorphism, and sequencing and phylogenetic analysis of a conservative region of the HAd hexon gene. The overall rate of HAd infection in childhood gastroenteritis cases during the 4-year study was 8.1%, with a gradual decrease in detection rates from 11.7% in 2003 to 5.7% in 2006. Molecular studies of a subset of HAd-positive samples found that enteric HAd type 40 strains were identified only in 2003 and 2004, while HAd type 41 strains were identified throughout the 4-year study. Higher detection rates of non-enteric HAds was documented during the first half of the study period when latex agglutination was used in our laboratory for detection. Our study suggests that the choice of diagnostic method may profoundly influence the epidemiologic picture and disease burden attributed to enteric HAd infections. [ABSTRACT FROM AUTHOR]
AB - Copyright of European Journal of Clinical Microbiology & Infectious Diseases is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - GASTROENTERITIS
KW - DISEASE incidence
KW - DIARRHEA
KW - GENETIC polymorphisms
KW - HUNGARY
N1 - Accession Number: 43596837; Bányai, K.; Email Address: bkrota@hotmail.com Kisfali, P. 1 Bogdán, Á. 2 Martella, V. 3 Melegh, B. 1 Erdman, D. 4 Szűcs, G. 2; Affiliation: 1: Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Szigeti út 12. Pécs 7624 Hungary 2: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7. Pécs 7623 Hungary 3: Department of Animal Health and Well-Being, University of Bari, Strada per Casamassima km 3 Valenzano, Bari 70010 Italy 4: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Atlanta 30333 USA; Source Info: Aug2009, Vol. 28 Issue 8, p997; Subject Term: ADENOVIRUSES; Subject Term: GASTROENTERITIS; Subject Term: DISEASE incidence; Subject Term: DIARRHEA; Subject Term: GENETIC polymorphisms; Subject Term: HUNGARY; Number of Pages: 3p; Illustrations: 1 Diagram; Document Type: Report
L3 - 10.1007/s10096-009-0722-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43596837&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hongwei Hsiao
AU - Whitestone, Jennifer
AU - Taylor, Stacie
AU - Godby, Mary
AU - Guan, Jinhua
T1 - Harness Sizing and Strap Length Configurations.
JO - Human Factors
JF - Human Factors
Y1 - 2009/08//
VL - 51
IS - 4
M3 - Article
SP - 497
EP - 518
SN - 00187208
AB - Objective: This article describes the derivation of strap lengths and adjustments to fall-arrest harnesses and the development of harness size configurations. Background: Updated harness sizing configurations are needed to accommodate diverse populations in the current workforce. Method: Three-dimensional torso anthropometric data from 243 women and 258 men were incorporated into eight validated equations to develop a cost-effective harness sizing plan and to define strap lengths. Results: To met strap adjustable range goals and to accommodate 95% to 98% of the estimated population, two sizing options were identified. Conclusion: Study outcomes suggest system improvement with three to four sizes for women and three to four sizes for men, on which the adjustment ranges of the torso straps were within 15 to 17 cm and within 20 to 23 cm on thigh and hip straps. Application: This research provided harness sizing and cut-length information for harness design to reduce the risk of worker injury that results from poor fit or improper size selection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Human Factors is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFIGURATIONS (Geometry)
KW - ANTHROPOMETRY
KW - COST effectiveness
KW - HARNESSES (Sporting goods)
KW - INDUSTRIAL safety
N1 - Accession Number: 44482806; Hongwei Hsiao 1; Email Address: hhsiao@cdc.gov Whitestone, Jennifer 2 Taylor, Stacie 3 Godby, Mary 4 Guan, Jinhua 1; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, West Virginia 2: Total Contact, Germantown, Ohio 3: Tailored Statistical Solutions, Dayton, Ohio 4: Sumaria Systems, Wright- Patterson Air Force Base, Ohio; Source Info: Aug2009, Vol. 51 Issue 4, p497; Subject Term: CONFIGURATIONS (Geometry); Subject Term: ANTHROPOMETRY; Subject Term: COST effectiveness; Subject Term: HARNESSES (Sporting goods); Subject Term: INDUSTRIAL safety; Number of Pages: 22p; Document Type: Article
L3 - 10.1177/0018720809346320
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44482806&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105241177
T1 - Harness sizing and strap length configurations.
AU - Hsiao H
AU - Whitestone J
AU - Taylor S
AU - Godby M
AU - Guan J
AU - Hsiao, Hongwei
AU - Whitestone, Jennifer
AU - Taylor, Stacie
AU - Godby, Mary
AU - Guan, Jinhua
Y1 - 2009/08//
N1 - Accession Number: 105241177. Language: English. Entry Date: 20100115. Revision Date: 20170228. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 0374660.
KW - Accidental Falls -- Prevention and Control
KW - Accidents, Occupational -- Prevention and Control
KW - Equipment Design
KW - Ergonomics
KW - Protective Devices -- Standards
KW - Body Size
KW - Female
KW - Human
KW - Male
SP - 497
EP - 518
JO - Human Factors
JF - Human Factors
JA - HUM FACTORS
VL - 51
IS - 4
PB - Sage Publications Inc.
AB - Objective: This article describes the derivation of strap lengths and adjustments to fall-arrest harnesses and the development of harness size configurations.Background: Updated harness sizing configurations are needed to accommodate diverse populations in the current workforce.Method: Three-dimensional torso anthropometric data from 243 women and 258 men were incorporated into eight validated equations to develop a cost-effective harness sizing plan and to define strap lengths.Results: To met strap adjustable range goals and to accommodate 95% to 98% of the estimated population, two sizing options were identified.Conclusion: Study outcomes suggest system improvement with three to four sizes for women and three to four sizes for men, on which the adjustment ranges of the torso straps were within 15 to 17 cm and within 20 to 23 cm on thigh and hip straps.Application: This research provided harness sizing and cut-length information for harness design to reduce the risk of worker injury that results from poor fit or improper size selection.
SN - 0018-7208
AD - Protective Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA
AD - Protective Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA. hhsiao@cdc.gov
U2 - PMID: 19899360.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105241177&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cox-Ganser, J. M.
AU - Rao, C. Y.
AU - Park, J.-H.
AU - Schumpert, J. C.
AU - Kreiss, K.
T1 - Asthma and respiratory symptoms in hospital workers related to dampness and biological contaminants.
JO - Indoor Air
JF - Indoor Air
Y1 - 2009/08//
VL - 19
IS - 4
M3 - Article
SP - 280
EP - 290
PB - Wiley-Blackwell
SN - 09056947
AB - The National Institute for Occupational Safety and Health investigated respiratory symptoms and asthma in relation to damp indoor environments in employees of two hospitals. A cluster of six work-related asthma cases from one hospital department, whose symptoms arose during a time of significant water incursions, led us to conduct a survey of respiratory health in 1171/1834 employees working in the sentinel cases hospital and a nearby hospital without known indoor environmental concerns. We carried out observational assessment of dampness, air, chair, and floor dust sampling for biological contaminants, and investigation of exposure-response associations for about 500 participants. Many participants with post-hire onset asthma reported diagnosis dates in a period of water incursions and renovations. Post-hire asthma and work-related lower respiratory symptoms were positively associated with the dampness score. Work-related lower respiratory symptoms showed monotonically increasing odds ratios with ergosterol, a marker of fungal biomass. Other fungal and bacterial indices, particle counts, cat allergen and latex allergen were associated with respiratory symptoms. Our data imply new-onset of asthma in relation to water damage, and indicate that work-related respiratory symptoms in hospital workers may be associated with diverse biological contaminants. [ABSTRACT FROM AUTHOR]
AB - Copyright of Indoor Air is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Asthma
KW - Dampness in buildings
KW - Biomass
KW - Respiratory diseases
KW - Hospital personnel
KW - Building-related asthma
KW - Dampness
KW - Ergosterol
KW - Healthcare workers
KW - Indoor environmental quality
KW - Mold
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 43198499; Cox-Ganser, J. M. 1; Email Address: Jcoxganser@cdc.gov; Rao, C. Y. 1; Park, J.-H. 1; Schumpert, J. C. 2; Kreiss, K. 1; Affiliations: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA; 2: Resources for Environmental and Occupational Health, Inc., Missoula, MT, USA; Issue Info: Aug2009, Vol. 19 Issue 4, p280; Thesaurus Term: Asthma; Thesaurus Term: Dampness in buildings; Thesaurus Term: Biomass; Subject Term: Respiratory diseases; Subject Term: Hospital personnel; Author-Supplied Keyword: Building-related asthma; Author-Supplied Keyword: Dampness; Author-Supplied Keyword: Ergosterol; Author-Supplied Keyword: Healthcare workers; Author-Supplied Keyword: Indoor environmental quality; Author-Supplied Keyword: Mold ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 11p; Illustrations: 6 Charts, 3 Graphs; Document Type: Article
L3 - 10.1111/j.1600-0668.2009.00586.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43198499&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Takata, Ayako
AU - Yamauchi, Hiroshi
AU - Toya, Tadao
AU - Aminaka, Masahito
AU - Shinohara, Yasushi
AU - Kohyama, Norihiko
AU - Yoshida, Katsumi
T1 - Forsterite exposure causes less oxidative DNA damage and lung injury than chrysotile exposure in rats.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2009/08//
VL - 21
IS - 9
M3 - Article
SP - 739
EP - 746
SN - 08958378
AB - Chrysotile (CH) is a pathogenic waste building material that can potentially be rendered innocuous via conversion to forsterite (FO) by heating at high temperatures. We compared the ability of FO and CH to cause oxidative DNA damage and lung injury. A single 1-mg intratracheal dose of CH or FO was administered to rats. Significant changes were observed 3 to 7 days after CH injection in alveolar macrophages, neutrophils, eosinophils, lymphocytes, total protein, and lactate dehydrogenase. High concentrations of 8-hydroxy-29-deoxyguanosine (8-OHdG) were also observed in the macrophages, other infiltrating inflammatory cells, granulomas, and in bronchiolar and alveolar epithelial cells. The overexpression of 8-OHdG was limited to airway epithelial and inflammatory cells surrounding the fibrotic foci 540 days after injection, indicating that the inflammatory effects of CH were persistent yet decreased with time. Compared to the CH group, acute lung inflammation observed in the FO group was less apparent and exhibited no progressive fibrosing lesions. The expression of 8-OHdG was transient and weak in the bronchiolar epithelial cells as well as in the inflammatory cells, consistent with low concentrations of 8-OHdG observed in the lungs. These findings confirm that FO causes significantly less inflammation and oxidative DNA damage in the lungs than CH. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Waste products
KW - WOUNDS & injuries
KW - Serpentine
KW - Olivine
KW - Lungs
KW - Biochemical genetics
KW - 8-OHdG
KW - Chrysotile
KW - lung injury
KW - oxidative DNA damage
KW - synthetic forsterite
N1 - Accession Number: 43493644; Takata, Ayako 1; Email Address: ayakot@marianna-u.ac.jp; Yamauchi, Hiroshi 2; Toya, Tadao 3; Aminaka, Masahito 1; Shinohara, Yasushi 3; Kohyama, Norihiko 4; Yoshida, Katsumi 1; Affiliations: 1: Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki0000; 2: Department of Public Health, School of Allied Health Science, Kitasato University, Sagamihara; 3: National Institute of Occupational Safety and Health, Kawasaki; 4: Natural Science Laboratory, Faculty of Economics, Toyo University, Tokyo, Japan; Issue Info: Aug2009, Vol. 21 Issue 9, p739; Thesaurus Term: Waste products; Thesaurus Term: WOUNDS & injuries; Subject Term: Serpentine; Subject Term: Olivine; Subject Term: Lungs; Subject Term: Biochemical genetics; Author-Supplied Keyword: 8-OHdG; Author-Supplied Keyword: Chrysotile; Author-Supplied Keyword: lung injury; Author-Supplied Keyword: oxidative DNA damage; Author-Supplied Keyword: synthetic forsterite; NAICS/Industry Codes: 212325 Clay and Ceramic and Refractory Minerals Mining; NAICS/Industry Codes: 212326 Shale, clay and refractory mineral mining and quarrying; NAICS/Industry Codes: 212319 Other Crushed and Broken Stone Mining and Quarrying; NAICS/Industry Codes: 212311 Dimension Stone Mining and Quarrying; NAICS/Industry Codes: 212316 Marble mining and quarrying; NAICS/Industry Codes: 423930 Recyclable Material Merchant Wholesalers; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562111 Solid Waste Collection; Number of Pages: 8p; Illustrations: 2 Color Photographs, 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/08958370802492399
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Fricke, W. Florian
AU - Welch, Timothy J.
AU - McDermott, Patrick F.
AU - Mammel, Mark K.
AU - LeClerc, J. Eugene
AU - White, David G.
AU - Cebula, Thomas A.
AU - Ravel, Jacques
T1 - Comparative Genomics of the IncA/C Multidrug Resistance Plasmid Family.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2009/08//
VL - 191
IS - 15
M3 - Article
SP - 4750
EP - 4757
SN - 00219193
AB - Multidrug resistance (MDR) plasmids belonging to the IncA/C plasmid family are widely distributed among Salmonella and other enterobacterial isolates from agricultural sources and have, at least once, also been identified in a drug-resistant Yersinia pestis isolate (IP275) from Madagascar. Here, we present the complete plasmid sequences of the IncA/C reference plasmid pRA1 (143,963 bp), isolated in 1971 from the fish pathogen Aeromonas hydrophila, and of the cryptic IncA/C plasmid pRAx (49,763 bp), isolated from Escherichia coli transconjugant D7-3, which was obtained through pRA1 transfer in 1980. Using comparative sequence analysis of pRA1 and pRAx with recent members of the IncA/C plasmid family, we show that both plasmids provide novel insights into the evolution of the IncA/C MDR plasmid family and the minimal machinery necessary for stable IncA/C plasmid maintenance. Our results indicate that recent members of the IncA/C plasmid family evolved from a common ancestor, similar in composition to pRA1, through stepwise integration of horizontally acquired resistance gene arrays into a conserved plasmid backbone. Phylogenetic comparisons predict type IV secretion-like conjugative transfer operons encoded on the shared plasmid backbones to be closely related to a group of integrating conjugative elements, which use conjugative transfer for horizontal propagation but stably integrate into the host chromosome during vegetative growth. A hipAB toxin-antitoxin gene cluster found on pRA1, which in Escherichia coli is involved in the formation of persister cell subpopulations, suggests persistence as an early broad-spectrum antimicrobial resistance mechanism in the evolution of IncA/C resistance plasmids. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOBILE genetic elements
KW - ENTEROBACTERIACEAE
KW - MULTIDRUG resistance
KW - MOLECULAR genetics
KW - PLASMIDS
KW - ESCHERICHIA coli
KW - GENETIC transcription
KW - SALMONELLA
KW - CELL nuclei
N1 - Accession Number: 44086476; Fricke, W. Florian 1 Welch, Timothy J. 2 McDermott, Patrick F. 3 Mammel, Mark K. 4 LeClerc, J. Eugene 4 White, David G. 3 Cebula, Thomas A. 5 Ravel, Jacques 1; Email Address: jravel@som.umaryland.edu; Affiliation: 1: Institute for Genome Sciences (IGS), University of Maryland School of Medicine, Baltimore, Maryland 21201 2: National Center for Cool and Cold Water Aquaculture, United States Department of Agriculture, Kearneysville, West Virginia 25430 3: Center for Veterinary Medicine-Food and Drug Administration (CVM-FDA), Laurel, Maryland 20708 4: Center for Food Safety and Applied Nutrition-Food and Drug Administration (CFSAN-FDA), Laurel, Maryland 20708 5: Johns Hopkins University, Baltimore, Maryland 21218; Source Info: Aug2009, Vol. 191 Issue 15, p4750; Subject Term: MOBILE genetic elements; Subject Term: ENTEROBACTERIACEAE; Subject Term: MULTIDRUG resistance; Subject Term: MOLECULAR genetics; Subject Term: PLASMIDS; Subject Term: ESCHERICHIA coli; Subject Term: GENETIC transcription; Subject Term: SALMONELLA; Subject Term: CELL nuclei; Number of Pages: 8p; Document Type: Article
L3 - 10.1128/JB.00189-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44086476&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sosnik, Julian
AU - Miranda, Patricia V.
AU - Spiridonov, Nikolay A.
AU - Sook-Young Yoon
AU - Fissore, Rafael A.
AU - Johnson, Gibbes R.
AU - Visconti, Pablo E.
T1 - Tssk6 is required for Izumo relocalization and gamete fusion in the mouse.
JO - Journal of Cell Science
JF - Journal of Cell Science
Y1 - 2009/08//8/1/2009
VL - 122
IS - 15
M3 - Article
SP - 17
EP - 17
SN - 00219533
AB - One of the most important processes in fertilization is the fusion of egg and sperm; however, the molecular mechanisms involved in this process are not well understood. So far, using genetic approaches, only two proteins have been demonstrated to be necessary for this process: Izumo in sperm and CD9 in the egg. Here we demonstrate that sperm produced by Tssk6 (Sstk)-null mice present defects that prevent the successful fertilization of eggs in vitro and the fusion to zona-pellucida-free eggs. Tssk6 is a member of the testis-specific serine kinase family of proteins and is expressed postmeiotically in male germ cells. In order for fusion to occur, during the process known as acrosome reaction Izumo needs to relocate from the anterior head to other regions, including the postacrosomal compartment. Tssk6-null sperm fails to relocate Izumo during the acrosome reaction. Agents that interfere with actin dynamics blocked the acrosome-reaction-associated translocation of Izumo that is required for fusion in wild-type sperm. Additionally, actin polymerization was compromised in Tssk6-null sperm. Taken together, our results indicate that Tssk6 is involved in sperm-egg fusion through the regulation of actin polymerization and changes in Izumo localization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cell Science is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FERTILIZATION in vitro
KW - SPERMATOZOA
KW - GAMETES
KW - ACTIN
KW - CLINICAL trials
KW - Acrosome reaction
KW - Fertilization
KW - Gamete fusion
KW - Izumo
KW - Tssk6 (Sstk)
N1 - Accession Number: 43477902; Sosnik, Julian 1,2 Miranda, Patricia V. 1,3 Spiridonov, Nikolay A. 4 Sook-Young Yoon 1 Fissore, Rafael A. 1,2 Johnson, Gibbes R. 4 Visconti, Pablo E. 1; Email Address: pvisconti@vasci.umass.edu; Affiliation: 1: Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA 2: Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA 3: Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires 1428, Argentina 4: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: 8/1/2009, Vol. 122 Issue 15, p17; Subject Term: FERTILIZATION in vitro; Subject Term: SPERMATOZOA; Subject Term: GAMETES; Subject Term: ACTIN; Subject Term: CLINICAL trials; Author-Supplied Keyword: Acrosome reaction; Author-Supplied Keyword: Fertilization; Author-Supplied Keyword: Gamete fusion; Author-Supplied Keyword: Izumo; Author-Supplied Keyword: Tssk6 (Sstk); NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 325413 In-Vitro Diagnostic Substance Manufacturing; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Boretti, Felicitas S.
AU - Buehler, Paul W.
AU - d'Agnillo, Felice
AU - Kluge, Katharina
AU - Glaus, Tony
AU - Butt, Omer I.
AU - Yiping Jia
AU - Goede, Jeroen
AU - Pereira, Claudia P.
AU - Maggiorini, Marco
AU - Schoedon, Gabriele
AU - Alayash, Abdu I.
AU - Schaer, Dominik J.
T1 - Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
Y1 - 2009/08//
VL - 119
IS - 8
M3 - Article
SP - 2271
EP - 2280
SN - 00219738
AB - Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias and severe malaria. These toxicities arise from Hb-mediated vasoactivity, possibly due to NO scavenging and localized tissue oxidative processes. Currently, there is no established treatment that targets circulating extracellular Hb. Here, we assessed the role of haptoglobin (Hp), the primary scavenger of Hb in the circulation, in limiting the toxicity of cell-free Hb infusion. Using a canine model, we found that glucocorticoid stimulation of endogenous Hp synthesis prevented Hb-induced hemodynamic responses. Furthermore, guinea pigs administered exogenous Hp displayed decreased Hb-induced hypertension and oxidative toxicity to extravascular environments, such as the proximal tubules of the kidney. The ability of Hp to both attenuate hypertensive responses during Hb exposure and prevent peroxidative toxicity in extravascular compartments was dependent on Hb-Hp complex formation, which likely acts through sequestration of Hb rather than modulation of its NO- and O2-binding characteristics. Our data therefore suggest that therapies involving supplementation of endogenous Hb scavengers may be able to treat complications of acute and chronic hemolysis, as well as counter the adverse effects associated with Hb-based oxygen therapeutics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HAPTOGLOBINS
KW - HEMOGLOBIN
KW - HEMOLYTIC anemia
KW - HEMOLYSIS & hemolysins
KW - DISEASES -- Causes & theories of causation
KW - HEMODYNAMICS
N1 - Accession Number: 43589821; Boretti, Felicitas S. 1 Buehler, Paul W. 2 d'Agnillo, Felice 2 Kluge, Katharina 1 Glaus, Tony 1 Butt, Omer I. 2 Yiping Jia 2 Goede, Jeroen 3 Pereira, Claudia P. 3 Maggiorini, Marco 3 Schoedon, Gabriele 3 Alayash, Abdu I. 2; Email Address: abdu.alayash@fda.hhs.gov Schaer, Dominik J. 3; Email Address: dominik.schaer@usz.ch; Affiliation: 1: Clinic for Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland 2: Center for Biologics Evaluation and Research, US FDA, Bethesda Maryland, USA 3: Department of Internal Medicine, University Hospital, Zurich, Switzerland; Source Info: Aug2009, Vol. 119 Issue 8, p2271; Subject Term: HAPTOGLOBINS; Subject Term: HEMOGLOBIN; Subject Term: HEMOLYTIC anemia; Subject Term: HEMOLYSIS & hemolysins; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: HEMODYNAMICS; Number of Pages: 10p; Illustrations: 1 Illustration, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1172/JCI39115
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jin, S. K.
AU - Kang, T. S.
AU - Eom, S. O.
AU - Kim, J.-I.
AU - Lee, H. J.
AU - Roh, J.
T1 - CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2009/08//
VL - 34
IS - 4
M3 - Article
SP - 437
EP - 446
PB - Wiley-Blackwell
SN - 02694727
AB - Background and objective: CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim of this study was to investigate the usefulness of CYP2C19 haplotypes as a marker of CYP2C19 enzyme activity in Koreans. Methods: We analysed the single nucleotide polymorphisms and haplotypes of the CYP2C19 gene in 150 healthy Koreans and found three major (frequency > 0·1) haplotypes (H1, H2 and H3). One oral dose of 40 mg omeprazole (Losec®) was administered to 30 subjects grouped as H1/H1, H2/H2, H1/H2, H1/H3 and H2/H3. The pharmacokinetics of omeprazole and its metabolites, 5-hydroxyomeprazole and omeprazole sulphone, in those groups was analysed. Results and discussion: The area under the plasma concentration–time curve (AUC0→∞) and elimination half-life ( T1/2) of omeprazole were significantly greater in the H2/H2 and H2/H3 groups than in the H1/H1 group ( P < 0·05), whereas the metabolic ratios of omeprazole to 5-hydroxyomeprazole were also markedly higher. Conclusion: Although a specific SNP of CYP2C19 may be predictive of enzyme activity, haplotyping is more reliable for identifying poor metabolizers in populations with variant alleles other than CYP2C19*2 and *3 alleles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OMEPRAZOLE
KW - PROTON pump inhibitors
KW - GENETIC polymorphisms
KW - PHARMACOKINETICS
KW - CHEMICAL kinetics
KW - CYP2C19
KW - haplotype
KW - omeprazole
KW - pharmacokinetics
N1 - Accession Number: 42996726; Jin, S. K. 1,2 Kang, T. S. 1 Eom, S. O. 1 Kim, J.-I. 1 Lee, H. J. 2; Email Address: hwalee@ewha.ac.kr Roh, J. 3; Email Address: rohjaesook@hanyang.ac.kr; Affiliation: 1: Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul. 2: College of Pharmacy, Ewha Womans University, Seoul, South Korea. 3: Deparment of Obstetrics & Gynecology, Hanyang University Medical Center, Seoul, South Korea.; Source Info: Aug2009, Vol. 34 Issue 4, p437; Subject Term: OMEPRAZOLE; Subject Term: PROTON pump inhibitors; Subject Term: GENETIC polymorphisms; Subject Term: PHARMACOKINETICS; Subject Term: CHEMICAL kinetics; Author-Supplied Keyword: CYP2C19; Author-Supplied Keyword: haplotype; Author-Supplied Keyword: omeprazole; Author-Supplied Keyword: pharmacokinetics; Number of Pages: 10p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2710.2008.01012.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=42996726&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105381837
T1 - CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.
AU - Jin SK
AU - Kang TS
AU - Eom SO
AU - Kim J
AU - Lee HJ
AU - Roh J
Y1 - 2009/08//
N1 - Accession Number: 105381837. Language: English. Entry Date: 20090911. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Korea Food and Drug Administration. NLM UID: 8704308.
KW - Biological Markers
KW - Enzymes -- Metabolism
KW - Hemeproteins
KW - Omeprazole -- Pharmacokinetics
KW - Adult
KW - Alleles
KW - Female
KW - Funding Source
KW - Genotype
KW - Korea
KW - Male
KW - One-Way Analysis of Variance
KW - Polymorphism, Genetic
KW - Human
SP - 437
EP - 446
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
JA - J CLIN PHARM THER
VL - 34
IS - 4
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - BACKGROUND AND OBJECTIVE: CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim of this study was to investigate the usefulness of CYP2C19 haplotypes as a marker of CYP2C19 enzyme activity in Koreans. METHODS: We analysed the single nucleotide polymorphisms and haplotypes of the CYP2C19 gene in 150 healthy Koreans and found three major (frequency > 0.1) haplotypes (H1, H2 and H3). One oral dose of 40 mg omeprazole (Losec) was administered to 30 subjects grouped as H1/H1, H2/H2, H1/H2, H1/H3 and H2/H3. The pharmacokinetics of omeprazole and its metabolites, 5-hydroxyomeprazole and omeprazole sulphone, in those groups was analysed. RESULTS AND DISCUSSION: The area under the plasma concentration-time curve (AUC(0-->infinity)) and elimination half-life (T(1/2)) of omeprazole were significantly greater in the H2/H2 and H2/H3 groups than in the H1/H1 group (P < 0.05), whereas the metabolic ratios of omeprazole to 5-hydroxyomeprazole were also markedly higher. CONCLUSION: Although a specific SNP of CYP2C19 may be predictive of enzyme activity, haplotyping is more reliable for identifying poor metabolizers in populations with variant alleles other than CYP2C19*2 and *3 alleles.
SN - 0269-4727
AD - Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea.
U2 - PMID: 19583677.
DO - 10.1111/j.1365-2710.2008.01012.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105381837&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105355209
T1 - Disparities in obesity and overweight prevalence among US immigrant children and adolescents by generational status.
AU - Singh GK
AU - Kogan MD
AU - Yu SM
Y1 - 2009/08//
N1 - Accession Number: 105355209. Language: English. Entry Date: 20090821. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 7600747.
KW - Immigrants
KW - Pediatric Obesity -- United States
KW - Adolescence
KW - Asians
KW - Blacks
KW - Chi Square Test
KW - Child
KW - Confidence Intervals
KW - Female
KW - Hispanics
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - Socioeconomic Factors
KW - Surveys
KW - T-Tests
KW - United States
KW - Whites
KW - Human
SP - 271
EP - 281
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 34
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - We examined the prevalence and socio-behavioral correlates of obesity and overweight among 46,707 immigrant and US-born children and adolescents aged 10-17 years. The 2003 National Survey of Children's Health was used to estimate obesity and overweight prevalence among children in 12 immigrant groups, stratified by race/ethnicity and generational status. Logistic regression was used to examine immigrant differentials in the prevalence and odds of obesity and overweight. Obesity and overweight prevalence varied from a low of 6 and 18% for second-generation Asian immigrants to a high of 24 and 42% for native-born black children (US-born black children with US-born parents), respectively. After adjusting for age, gender, ethnicity, socioeconomic status, perceived neighborhood safety, television viewing, computer use, and physical activity, first-generation immigrant children, overall, had 26% lower odds of obesity than native-born children. Obesity and overweight prevalence was lower for immigrant black and white children than their native-born counterparts, while obesity and overweight prevalence among Hispanic children did not vary significantly by generational status. Compared with native-born white children, the adjusted odds of obesity were 64% higher for native-born blacks, 55% higher for second-generation Hispanic immigrants, and 63% lower for first-generation Asian immigrants. Adjusted immigrant differentials in overweight risks were also marked. Socioeconomic, demographic, and behavioral factors accounted for 61 and 35% of ethnic-immigrant disparities in obesity and overweight prevalence, respectively. Immigrant patterns in childhood obesity and overweight vary substantially by ethnicity and generational status. To reduce disparities, obesity prevention programs must target at-risk children of both immigrant and US-born parents.
SN - 0094-5145
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD 20857, USA. gsingh@hrsa.gov
U2 - PMID: 19333745.
DO - 10.1007/s10900-009-9148-6
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Maduri, A.
AU - Wilson, S.E.
T1 - Lumbar position sense with extreme lumbar angle
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
Y1 - 2009/08//
VL - 19
IS - 4
M3 - Article
SP - 607
EP - 613
SN - 10506411
AB - Abstract: Tasks involving flexed torso postures have a high incidence of low back injuries. Changes in the ability to sense and adequately control low back motion may play a role in these injuries. Previous studies examining position sense errors of the lumbar spine with torso flexion found significant increases in error with flexion. However, there has been little research on the effect of lumbar angle. In this study, the aim of the study was to examine how position sense errors would change with torso flexion as a function of the target lumbar angle. Fifteen healthy volunteers were asked to assume three different lumbar angles (maximum, minimum and mid-range) at three different torso flexion angles. A reposition sense protocol was used to determine a subject’s ability to reproduce the target lumbar angles. Reposition sense error was found to increase 69% with increased torso flexion for mid-range target curvatures. With increasing torso flexion, the increase in reposition sense errors suggests a reduction in sensation and control in the lumbar spine that may increase risk of injury. However, the reposition error was smaller at high torso flexion angles in the extreme target curvatures. Higher sensory feedback at extreme lumbar angles would be important in preventing over-extension or over-flexion. These results suggest that proprioceptive elements in structures engaged at limits (such as the ligaments and facet joints), may provide a role in sensing position at extreme lumbar angles. Sensory elements in the muscles crossing the joint may also provide increased feedback at the edges of the range of motion. [Copyright &y& Elsevier]
AB - Copyright of Journal of Electromyography & Kinesiology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALCULUS
KW - MATHEMATICAL analysis
KW - INFINITESIMAL geometry
KW - FUNCTIONS (Mathematics)
KW - Lumbar
KW - Motor control
KW - Proprioception
KW - Spine biomechanics
N1 - Accession Number: 41584817; Maduri, A. 1 Wilson, S.E. 2; Email Address: sewilson@ku.edu; Affiliation: 1: National Institute for Occupational Safety and Health, Morgantown, WV, United States 2: Department of Mechanical Engineering, Human Motion Control Laboratory, University of Kansas, 1530 West 15th Street, Lawrence, KS 66045, United States; Source Info: Aug2009, Vol. 19 Issue 4, p607; Subject Term: CALCULUS; Subject Term: MATHEMATICAL analysis; Subject Term: INFINITESIMAL geometry; Subject Term: FUNCTIONS (Mathematics); Author-Supplied Keyword: Lumbar; Author-Supplied Keyword: Motor control; Author-Supplied Keyword: Proprioception; Author-Supplied Keyword: Spine biomechanics; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.jelekin.2008.03.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41584817&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105368722
T1 - Lumbar position sense with extreme lumbar angle.
AU - Maduri A
AU - Wilson SE
AU - Maduri, A
AU - Wilson, S E
Y1 - 2009/08//
N1 - Accession Number: 105368722. Language: English. Entry Date: 20090918. Revision Date: 20161115. Publication Type: journal article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: P20 RR016475-01/RR/NCRR NIH HHS/United States. NLM UID: 9109125.
KW - Balance, Postural -- Physiology
KW - Lumbar Vertebrae -- Physiology
KW - Movement -- Physiology
KW - Posture -- Physiology
KW - Range of Motion -- Physiology
KW - Adult
KW - Feedback -- Physiology
KW - Female
KW - Male
KW - Human
SP - 607
EP - 613
JO - Journal of Electromyography & Kinesiology
JF - Journal of Electromyography & Kinesiology
JA - J ELECTROMYOGR KINESIOL
VL - 19
IS - 4
CY - New York, New York
PB - Elsevier Science
AB - Tasks involving flexed torso postures have a high incidence of low back injuries. Changes in the ability to sense and adequately control low back motion may play a role in these injuries. Previous studies examining position sense errors of the lumbar spine with torso flexion found significant increases in error with flexion. However, there has been little research on the effect of lumbar angle. In this study, the aim of the study was to examine how position sense errors would change with torso flexion as a function of the target lumbar angle. Fifteen healthy volunteers were asked to assume three different lumbar angles (maximum, minimum and mid-range) at three different torso flexion angles. A reposition sense protocol was used to determine a subject's ability to reproduce the target lumbar angles. Reposition sense error was found to increase 69% with increased torso flexion for mid-range target curvatures. With increasing torso flexion, the increase in reposition sense errors suggests a reduction in sensation and control in the lumbar spine that may increase risk of injury. However, the reposition error was smaller at high torso flexion angles in the extreme target curvatures. Higher sensory feedback at extreme lumbar angles would be important in preventing over-extension or over-flexion. These results suggest that proprioceptive elements in structures engaged at limits (such as the ligaments and facet joints), may provide a role in sensing position at extreme lumbar angles. Sensory elements in the muscles crossing the joint may also provide increased feedback at the edges of the range of motion.
SN - 1050-6411
AD - National Institute for Occupational Safety and Health, Morgantown, WV, United States
AD - National Institute for Occupational Safety and Health, Morgantown, WV, United States.
U2 - PMID: 18462951.
DO - 10.1016/j.jelekin.2008.03.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105368722&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - BREHM-STECHER, BYRON
AU - YOUNG, CHARLES
AU - JAYKUS, LEE-ANN
AU - TORTORELLO, MARY LOU
T1 - Sample Preparation: The Forgotten Beginning.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/08//
VL - 72
IS - 8
M3 - Article
SP - 1774
EP - 1789
SN - 0362028X
AB - Advances in molecular technologies and automated instrumentation have provided many opportunities for improved detection and identification of microorganisms; however, the upstream sample preparation steps needed to apply these advances to foods have not been adequately researched or developed. Thus, the extent to which these advances have improved food microbiology has been limited. The purpose of this review is to present the current state of sample preparation, to identify knowledge gaps and opportunities for improvement, and to recognize the need to support greater research and development efforts on preparative methods in food microbiology. The discussion focuses on the need to push technological developments toward methods that do not rely on enrichment culture. Among the four functional components of microbiological analysis (i.e., sampling, separation, concentration, detection), the separation and concentration components need to be researched more extensively to achieve rapid, direct, and quantitative methods. The usefulness of borrowing concepts of separation and concentration from other disciplines and the need to regard the microorganism as a physicochemical analyte that may be directly extracted from the food matrix are discussed. The development of next-generation systems that holistically integrate sample preparation with rapid, automated detection will require interdisciplinary collaboration and substantially increased funding. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Microbiology
KW - Microorganisms
KW - Food -- Safety measures
KW - Food spoilage
KW - Sample preparation (Chemistry)
N1 - Accession Number: 44092764; BREHM-STECHER, BYRON 1; YOUNG, CHARLES 2; JAYKUS, LEE-ANN 3; TORTORELLO, MARY LOU 4; Email Address: mary.tortorello@fda.hhs.gov; Affiliations: 1: Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA; 2: National Security and Technology Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, Maryland 20723, USA; 3: Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina 27695-7624, USA; 4: U.S. Food and Drug Administration, National Center for Food Safety and Technology, 6502 South Archer Road, Summit-Argo, Illinois 60501, USA; Issue Info: Aug2009, Vol. 72 Issue 8, p1774; Thesaurus Term: Food -- Microbiology; Thesaurus Term: Microorganisms; Thesaurus Term: Food -- Safety measures; Thesaurus Term: Food spoilage; Subject Term: Sample preparation (Chemistry); Number of Pages: 16p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44092764&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YANPING LUO
AU - JINGYUN LI
AU - YUE MA
AU - CHANGQIN HU
AU - SHAOHONG JIN
AU - SHENGHUI CUI
T1 - ISOLATION AND CHARACTERIZATION OF NONTYPHOID SALMONELLA FROM HOSPITAL FOOD HANDLERS IN BEIJING, CHINA.
JO - Journal of Food Safety
JF - Journal of Food Safety
Y1 - 2009/08//
VL - 29
IS - 3
M3 - Article
SP - 414
EP - 423
SN - 01496085
AB - Salmonella enterica isolates recovered from stool samples of healthy food handlers in two hospital dining halls in Beijing, China were characterized by serotyping, susceptibility to 15 antimicrobials and pulsed field gel electrophoresis (PFGE). Our data showed that 9.5% (29/305) of food handlers in these two dining halls were Salmonella carriers. Twenty-nine isolates were grouped into five serotypes including Agona, Derby, Enteritidis, Infantis and Senftenberg. All six Enteritidis isolates were resistant to chloramphenicol, nalidixic acid and tetracycline. Identical PFGE patterns were identified from food handlers in the same dining hall that indicated the possible transmission of Salmonella among food handlers and to customers. Our findings underscore the importance of food hygiene education and regular health examination among food handlers in dining halls in China. PRACTICAL APPLICATIONS Food handlers in dining halls should be considered as a high-risk group for Salmonella carrier state in China. Food hygiene education and regular health examination among food handlers in dining halls should be carried out. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Safety is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA
KW - HOSPITALS
KW - SALMONELLA diseases
KW - BEIJING (China)
KW - CHINA
N1 - Accession Number: 43522449; YANPING LUO 1 JINGYUN LI 2 YUE MA 2 CHANGQIN HU 2 SHAOHONG JIN 2 SHENGHUI CUI 2; Email Address: cuishenghui@yahoo.com; Affiliation: 1: Department of Microbiology, General Hospital of PLA, Beijing, China 2: National Center for Surveillance of Antimicrobial Resistance, The State Food and Drug Administration, Beijing, China; Source Info: Aug2009, Vol. 29 Issue 3, p414; Subject Term: SALMONELLA; Subject Term: HOSPITALS; Subject Term: SALMONELLA diseases; Subject Term: BEIJING (China); Subject Term: CHINA; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 10p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1111/j.1745-4565.2009.00165.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43522449&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - TOURNAS, VALERIE H.
T1 - MICROBIAL CONTAMINATION OF SELECT DIETARY SUPPLEMENTS.
JO - Journal of Food Safety
JF - Journal of Food Safety
Y1 - 2009/08//
VL - 29
IS - 3
M3 - Article
SP - 430
EP - 442
SN - 01496085
AB - One hundred thirty-eight dietary supplement samples comprised of alfalfa, Circu-Care, coriander, cumin, echinacea, garlic, ginger, ginkgo, horse chestnut extract, juniper berries, licorice, psyllium, saw palmetto, St. John's wort, valerian, white willow bark, and various vitamins and minerals were obtained from local supermarkets and dietary supplement companies and analyzed for fungal contamination and the presence of aerobic mesophilic bacteria. Results indicated that the highest mold and yeast counts of 5.6 × 106 colony forming units (cfu) per gram product were found in alfalfa and the lowest (1.0 × 102 cfu/g) were present in ginger supplements. Potentially toxigenic molds were found in alfalfa, coriander, echinacea, garlic, ginkgo, juniper, licorice, psyllium and St. John's wort supplements. The most common fungi were aspergilli, followed by eurotia, penicillia and yeasts. Alternaria alternata, Fusarium, Cladosporium, Rhizopus and Phoma spp. were isolated less frequently. No molds or yeasts were found in synthetic vitamins, minerals, Circu-Care and valerian. Aerobic mesophilic bacteria were isolated from all commodities tested. The highest aerobic plate count numbers (5.2 × 106–3.8 × 107 cfu/g) were recovered from alfalfa, whereas the lowest (<100–5.5 × 102 cfu/g) were found in vitamins and minerals. PRACTICAL APPLICATIONS With an ever-increasing population utilizing dietary supplements in order to improve and sustain health and vitality, it is essential that these products are safe for human consumption. A very critical indicator of safety is the bacteriological and mycological quality of these commodities. The results of this investigation constitute an indicator of mycological/bacteriological contamination of a variety of dietary supplements. Similar testing has not been reported for several of the studied commodities. Therefore, our findings can serve as a basis for future mycological and mycotoxin testing of dietary supplements and eventually for developing guidelines in order to achieve and maintain safe microbial levels in these products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Safety is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROBIAL contamination
KW - DIETARY supplements
KW - CONTAMINATION (Technology)
KW - NUTRITION
KW - VITAMINS
N1 - Accession Number: 43522447; TOURNAS, VALERIE H. 1; Email Address: valerie.tournas@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740; Source Info: Aug2009, Vol. 29 Issue 3, p430; Subject Term: MICROBIAL contamination; Subject Term: DIETARY supplements; Subject Term: CONTAMINATION (Technology); Subject Term: NUTRITION; Subject Term: VITAMINS; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 13p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1111/j.1745-4565.2009.00167.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43522447&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - BURNHAM, V. E.
AU - JANES, M. E.
AU - JAKUS, L. A.
AU - SUPAN, J.
AU - DEPAOLA, A.
AU - BELL, J.
T1 - Growth and Survival Differences of Vibrio vulnificus and Vibrio parahaemolyticus Strains during Cold Storage.
JO - Journal of Food Science
JF - Journal of Food Science
Y1 - 2009/08//
VL - 74
IS - 6
M3 - Article
SP - M314
EP - M318
SN - 00221147
AB - Vibrio vulnificus and Vibrio parahaemolyticus are the most common Vibrio species associated with seafood illness in the United States. Our study was conducted to determine if strain-to-strain differences exist in the growth and survival of 8 different V. vulnificus and V. parahaemolyticus strains at low temperatures. By day 10, V. vulnificus strain 515-4C2 had significantly higher counts ( P < 0.05) (1.97 log CFU/g) compared with strains 3315, 1007, 29306 at 5 °C, which reached nondetectable levels. At 8 °C, strain 515-4C2 had significantly higher counts ( P < 0.05) (2.23 log CFU/mL) compared with 1007, 33815, 541(O) 49C, which reached nondetectable levels. At 10 °C, only V. vulnificus strain 33815 reached nondetectable levels. At 5 °C, V. parahaemolyticus strain 541(O) 57C had the highest counts (5.28 log CFU/g) by day 10 while strain 33847 had significantly lower counts (3.46 log CFU/g). After 10 d at 8 °C, V. parahaemolyticus strain M350A had the highest counts (7.97 log CFU/mL) while strain 541(O) 57C had the lowest counts (4.80 log CFU/mL). At 10 °C, V. parahaemolyticus strain NY477 had significantly higher counts ( P < 0.05) with 8.31 log CFU/mL compared with strain 33847, which had the lowest counts (6.77 log CFU/mL). Our research has shown that various V. vulnificus and V. parahaemolyticus strains vary in their ability to survive and grow at refrigeration temperatures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO vulnificus
KW - VIBRIO parahaemolyticus
KW - COLD storage
KW - FOOD -- Preservation
KW - SEAFOOD
KW - UNITED States
KW - cold storage
KW - strains
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
N1 - Accession Number: 43501643; BURNHAM, V. E. 1 JANES, M. E. 1; Email Address: mjanes@agcenter.lsu.edu JAKUS, L. A. 2 SUPAN, J. 3 DEPAOLA, A. 4 BELL, J. 1; Affiliation: 1: Dept. of Food Science, Louisiana State Univ. Agricultural Center, Baton Rouge, LA 70803, U.S.A. 2: Dept. of Food Science, North Carolina State Univ., Raleigh, NC 27695, U.S.A. 3: LA Sea Grant Coll Pr, Louisiana State Univ. Agricultural Center, Baton Rouge, LA 70803, U.S.A. 4: Gulf Coast Seafood Lab., U.S. Food and Drug Administration, Daulphin Island, AL 36538, U.S.A.; Source Info: Aug2009, Vol. 74 Issue 6, pM314; Subject Term: VIBRIO vulnificus; Subject Term: VIBRIO parahaemolyticus; Subject Term: COLD storage; Subject Term: FOOD -- Preservation; Subject Term: SEAFOOD; Subject Term: UNITED States; Author-Supplied Keyword: cold storage; Author-Supplied Keyword: strains; Author-Supplied Keyword: Vibrio parahaemolyticus; Author-Supplied Keyword: Vibrio vulnificus; NAICS/Industry Codes: 493120 Refrigerated Warehousing and Storage; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 445220 Fish and Seafood Markets; Number of Pages: 5p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1111/j.1750-3841.2009.01227.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Coelho, Sergio G.
AU - Choi, Wonseon
AU - Brenner, Michaela
AU - Miyamura, Yoshinori
AU - Yamaguchi, Yuji
AU - Wolber, Rainer
AU - Smuda, Christoph
AU - Batzer, Jan
AU - Kolbe, Ludger
AU - Ito, Shosuke
AU - Wakamatsu, Kazumasa
AU - Zmudzka, Barbara Z.
AU - Beer, Janusz Z.
AU - Miller, Sharon A.
AU - Hearing, Vincent J.
T1 - Short- and Long-Term Effects of UV Radiation on the Pigmentation of Human Skin.
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
Y1 - 2009/08//
VL - 14
IS - 1
M3 - Article
SP - 32
EP - 35
PB - Nature Publishing Group
SN - 10870024
AB - The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 32–35; doi:10.1038/jidsymp.2009.10 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology Symposium Proceedings is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation -- Physiological effect
KW - SKIN -- Cancer
KW - MELANOMA
KW - SKIN -- Aging
KW - HUMAN skin color
N1 - Accession Number: 43653053; Coelho, Sergio G. 1 Choi, Wonseon 1 Brenner, Michaela 1 Miyamura, Yoshinori 1 Yamaguchi, Yuji 1 Wolber, Rainer 2 Smuda, Christoph 2 Batzer, Jan 2 Kolbe, Ludger 2 Ito, Shosuke 3 Wakamatsu, Kazumasa 3 Zmudzka, Barbara Z. 4 Beer, Janusz Z. 4 Miller, Sharon A. 4 Hearing, Vincent J. 1; Email Address: hearingv@nih.gov; Affiliation: 1: Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 2: R&D Skin Research, Beiersdorf AG, Hamburg, Germany 3: Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan 4: Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Aug2009, Vol. 14 Issue 1, p32; Subject Term: ULTRAVIOLET radiation -- Physiological effect; Subject Term: SKIN -- Cancer; Subject Term: MELANOMA; Subject Term: SKIN -- Aging; Subject Term: HUMAN skin color; Number of Pages: 4p; Illustrations: 1 Color Photograph, 1 Chart; Document Type: Article
L3 - 10.1038/jidsymp.2009.10
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Laney, A. Scott
AU - Attfield, Michael D.
AU - Morfeld, Peter
AU - Payne, Stephen
AU - McCunney, Robert J.
T1 - Quartz Exposure Can Cause Pneumoconiosis in Coal Workers.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2009/08//
VL - 51
IS - 8
M3 - Letter
SP - 867
EP - 867
SN - 10762752
AB - A letter to the editor is presented in response to the article "What Component of Coal Causes Coal Workers' Pneumoconioisis (CWP)?" by R. J. McCunney, P. Morfeld and S. Payne.
KW - LETTERS to the editor
KW - LUNGS -- Dust diseases
N1 - Accession Number: 44085066; Laney, A. Scott 1 Attfield, Michael D. 1 Morfeld, Peter 2,3 Payne, Stephen 4 McCunney, Robert J. 4; Affiliation: 1: Surveillance Branch, Division of Respiratory Disease Studies National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Morgantown, WVa 2: Institute for Occupational, Epidemiology and Risk Assessment Evonik Industries Essen, Germany 3: Institute for Occupational Medicine Cologne University North Rhine-Westphalia, Germany 4: Department of Biological Engineering, Massachusetts Institute of Technology Cambridge, MA; Source Info: Aug2009, Vol. 51 Issue 8, p867; Subject Term: LETTERS to the editor; Subject Term: LUNGS -- Dust diseases; Number of Pages: 1p; Document Type: Letter
L3 - 10.1097/JOM.0b013e3181b2f311
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Johnson, Jonetta L.
AU - Eaton, Danice K.
AU - Pederson, Linda L.
AU - Lowry, Richard
T1 - Associations of Trying to Lose Weight, Weight Control Behaviors, and Current Cigarette Use Among US High School Students.
JO - Journal of School Health
JF - Journal of School Health
Y1 - 2009/08//
VL - 79
IS - 8
M3 - Article
SP - 355
EP - 360
PB - Wiley-Blackwell
SN - 00224391
AB - BACKGROUND: Approximately one-quarter of high school students currently use cigarettes. Previous research has suggested some youth use smoking as a method for losing weight. The purpose of this study was to describe the association of current cigarette use with specific healthy and unhealthy weight control practices among 9th–12th grade students in the United States. METHODS: Youth Risk Behavior Survey data (2005) were analyzed. Behaviors included current cigarette use, trying to lose weight, and current use of 2 healthy and 3 unhealthy behaviors to lose weight or to keep from gaining weight. Separate logistic regression models calculated adjusted odds ratios (AORs) for associations of current cigarette use with trying to lose weight (Model 1) and the 5 weight control behaviors, controlling for trying to lose weight (Model 2). RESULTS: In Model 1, compared with students who were not trying to lose weight, students who were trying to lose weight had higher odds of current cigarette use (AOR = 1.30, 95% CI: 1.15–1.49). In Model 2, the association of current cigarette use with the 2 healthy weight control behaviors was not statistically significant. Each of the 3 unhealthy weight control practices was significantly associated with current cigarette use, with AORs for each behavior approximately 2 times as high among those who engaged in the behavior, compared with those who did not. CONCLUSION: Some students may smoke cigarettes as a method of weight control. Inclusion of smoking prevention messages into existing weight management interventions may be beneficial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of School Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HIGH school students
KW - HIGH school students -- Health
KW - SCHOOL health services
KW - SCHOOL nursing
KW - ADOLESCENT smoking
KW - SMOKING
KW - HEALTH aspects
KW - Nnutrition and diet
KW - nutrition and diet
KW - risk behaviors
KW - Risk behaviors.
KW - Smoking and tobacco
N1 - Accession Number: 43221342; Johnson, Jonetta L. 1; Email Address: jonettaj@umich. edu Eaton, Danice K. 2; Email Address: DEaton@cdc.gov Pederson, Linda L. 3; Email Address: lindap@mindspring.com Lowry, Richard 4; Email Address: rxl1@cdc.gov; Affiliation: 1: Department of Health Behavior and Health Education, University of Michigan School of Public Health, 109 South Observatory Street, SPHI, Ann Arbor, MI 48109 2: Commander, United States Public Health Service, SERB/DASH/NCCDPHP/CDC, 4770 Buford Highway NE, MS K-33, Atlanta, GA 30341 3: Senior Scientific Advisor, Health Communications Branch Senior Service, Office on Smoking and Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS K-50, Atlanta, GA 30341 4: Medical Epidemiologist, SERB/DASH/NCCDPHP/CDC, 4770 Buford Highway NE, MS K-33, Atlanta, GA 30341; Source Info: Aug2009, Vol. 79 Issue 8, p355; Subject Term: HIGH school students; Subject Term: HIGH school students -- Health; Subject Term: SCHOOL health services; Subject Term: SCHOOL nursing; Subject Term: ADOLESCENT smoking; Subject Term: SMOKING; Subject Term: HEALTH aspects; Author-Supplied Keyword: Nnutrition and diet; Author-Supplied Keyword: nutrition and diet; Author-Supplied Keyword: risk behaviors; Author-Supplied Keyword: Risk behaviors.; Author-Supplied Keyword: Smoking and tobacco; Number of Pages: 6p; Illustrations: 3 Charts; Document Type: Article; Full Text Word Count: 4189
L3 - 10.1111/j.1746-1561.2009.00421.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43221342&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Xiangdong Zhu
AU - Kim, Jay H.
AU - Won Joon Song
AU - Murphy, William J.
AU - Seongho Song
T1 - Development of a noise metric for assessment of exposure risk to complex noises.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2009/08//
VL - 126
IS - 2
M3 - Article
SP - 703
EP - 712
SN - 00014966
AB - Many noise guidelines currently use A-weighted equivalent sound pressure level LAeq as the noise metric and the equal energy hypothesis to assess the risk of occupational noises. Because of the time-averaging effect involved with the procedure, the current guidelines may significantly underestimate the risk associated with complex noises. This study develops and evaluates several new noise metrics for more accurate assessment of exposure risks to complex and impulsive noises. The analytic wavelet transform was used to obtain time-frequency characteristics of the noise. 6 basic, unique metric forms that reflect the time-frequency characteristics were developed, from which 14 noise metrics were derived. The noise metrics were evaluated utilizing existing animal test data that were obtained by exposing 23 groups of chinchillas to, respectively, different types of noise. Correlations of the metrics with the hearing losses observed in chinchillas were compared and the most promising noise metric was identified. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOUND pressure
KW - RESEARCH
KW - NOISE (Work environment)
KW - NOISE pollution -- Research
KW - NOISE -- Measurement
KW - ACOUSTICS (Physical sciences)
N1 - Accession Number: 108973871; Xiangdong Zhu 1,2 Kim, Jay H. 1; Email Address: jay.kim@uc.edu Won Joon Song 1 Murphy, William J. 3 Seongho Song 4; Affiliation: 1: Department of Mechanical Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0072 2: Parker-Haniffin Corp., 6035 Parkland Blvd., Cleveland, OH 44124-4141 3: National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Engineering and Physical Hazards Branch, Hearing Loss Prevention Team, 4676 Columbia Parkway, MS C-27, Cincinnati, Ohio 45226-1998 4: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio 45221-0025; Source Info: Aug2009, Vol. 126 Issue 2, p703; Subject Term: SOUND pressure; Subject Term: RESEARCH; Subject Term: NOISE (Work environment); Subject Term: NOISE pollution -- Research; Subject Term: NOISE -- Measurement; Subject Term: ACOUSTICS (Physical sciences); Number of Pages: 10p; Document Type: Article
L3 - 10.1121/1.3159587
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hettick, Justin
AU - Ruwona, Tinashe
AU - Siegel, Paul
T1 - Structural elucidation of isocyanate-peptide adducts using tandem mass spectrometry.
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
Y1 - 2009/08//
VL - 20
IS - 8
M3 - Article
SP - 1567
EP - 1575
SN - 10440305
AB - Diisocyanates are highly reactive chemical compounds widely used in the manufacture of polyurethanes. Although diisocyanates have been identified as causative agents of allergic respiratory diseases, the specific mechanism by which these diseases occur is largely unknown. To better understand the chemical species produced when isocyanates are reacted with model peptides, tandem mass spectrometry was employed to unambiguously identify the binding site of four commercially-relevant isocyanates on model peptides. In each case, the isocyanates react preferentially with the N-terminus of the peptide. No evidence of side-chain/isocyanate adduct formation exclusive of the N-terminus was observed. However, significant intra-molecular diisocyanate crosslinking was observed between the N-terminal amine and a side-chain amine of arginine, when Arg was located within two residues of the N-terminus. Addition of multiple isocyanates to the peptide occurs via polymerization of the isocyanate at the N-terminus, rather than via addition of multiple isocyanate molecules to varied residues within the peptide. The direct observation of isocyanate binding to the N-terminus of peptides under these experimental conditions is in good agreement with previous studies on the relative reaction rate of isocyanate with amino acid functional groups. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the American Society for Mass Spectrometry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOCYANATES
KW - PEPTIDES
KW - ADDUCTS (Chemistry)
KW - TANDEM mass spectrometry
KW - RESPIRATORY diseases -- Risk factors
N1 - Accession Number: 98371683; Hettick, Justin 1; Email Address: jhettick@cdc.gov Ruwona, Tinashe 1 Siegel, Paul 1; Affiliation: 1: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, MS L-2040, 1095 Willowdale Road 26505 Morgantown USA; Source Info: Aug2009, Vol. 20 Issue 8, p1567; Subject Term: ISOCYANATES; Subject Term: PEPTIDES; Subject Term: ADDUCTS (Chemistry); Subject Term: TANDEM mass spectrometry; Subject Term: RESPIRATORY diseases -- Risk factors; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jasms.2009.04.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Grajkowska, Lucja T.
AU - Pedras-Vasconcelos, Joao A.
AU - Sauder, Christian
AU - Verthelyi, Daniela
AU - Puig, Montserrat
T1 - High-throughput real-time PCR for early detection and quantitation of arenavirus Tacaribe
JO - Journal of Virological Methods
JF - Journal of Virological Methods
Y1 - 2009/08//
VL - 159
IS - 2
M3 - Article
SP - 239
EP - 243
SN - 01660934
AB - Abstract: Arenaviruses merit significant attention both as causative agents of endemic hemorrhagic fevers and as model systems to study the immune response to acute and persistent viral infections. Development of highly sensitive quantitative screening methods to detect arenavirus is critical for early diagnosis of patients, to screen the rodent population in endemic areas, and as a research tool to confirm effective tissue clearance during the development of anti-viral strategies. This study describes a novel sensitive and reproducible method to quantify prototypic new world arenavirus Tacaribe RNA in cell cultures and tissues using a real-time TaqMan PCR-based detection system. The method has a sensitivity of 100 RNA copies per 200ng of total RNA, making it 2 logs more sensitive than the currently utilized TCID50 method, and a linear range from 102 to 109 copies/reaction. The qRT-PCR method is high-throughput and screening can be achieved in <2h allowing for diagnosis of infected patients before the onset of symptoms. This new method is a powerful tool to screen populations for infection and monitor the clearance achieved by available therapies, and serves as a model diagnostic tool for other arenaviruses. [Copyright &y& Elsevier]
AB - Copyright of Journal of Virological Methods is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction -- Diagnostic use
KW - ARENAVIRUSES
KW - VIRUSES -- Identification
KW - HEMORRHAGIC fever
KW - IMMUNE response
KW - RODENTS -- Population biology
KW - ANTIVIRAL agents
KW - Arenavirus
KW - cytopathic effect ( CPE )
KW - Diagnosis
KW - glycoprotein ( GP )
KW - qRT-PCR
KW - quantitative real-time-polymerase chain reaction ( qRT-PCR )
KW - Tacaribe
KW - tacaribe virus ( TCRV )
KW - tissue culture infectious dose 50 ( TCID50 )
KW - Viral hemorrhagic fever
N1 - Accession Number: 41239635; Grajkowska, Lucja T. 1 Pedras-Vasconcelos, Joao A. 1 Sauder, Christian 2 Verthelyi, Daniela 1; Email Address: Daniela.verthelyi@fda.hhs.gov Puig, Montserrat 1; Affiliation: 1: Division of Therapeutic Proteins, Office of Biotechnology Products, CDER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA 2: Division of Viral Products, Office of Vaccines Research and Review, CBER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA; Source Info: Aug2009, Vol. 159 Issue 2, p239; Subject Term: POLYMERASE chain reaction -- Diagnostic use; Subject Term: ARENAVIRUSES; Subject Term: VIRUSES -- Identification; Subject Term: HEMORRHAGIC fever; Subject Term: IMMUNE response; Subject Term: RODENTS -- Population biology; Subject Term: ANTIVIRAL agents; Author-Supplied Keyword: Arenavirus; Author-Supplied Keyword: cytopathic effect ( CPE ); Author-Supplied Keyword: Diagnosis; Author-Supplied Keyword: glycoprotein ( GP ); Author-Supplied Keyword: qRT-PCR; Author-Supplied Keyword: quantitative real-time-polymerase chain reaction ( qRT-PCR ); Author-Supplied Keyword: Tacaribe; Author-Supplied Keyword: tacaribe virus ( TCRV ); Author-Supplied Keyword: tissue culture infectious dose 50 ( TCID50 ); Author-Supplied Keyword: Viral hemorrhagic fever; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jviromet.2009.04.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Abdallah, Abdallah M.
AU - Verboom, Theo
AU - Weerdenburg, Eveline M.
AU - Pittius, Nicolaas C. Gey van
AU - Mahasha, Phetole W.
AU - Jiménez, Connie
AU - Parra, Marcela
AU - Cadieux, Nathalie
AU - Brennan, Michael J.
AU - Appelmelk, Ben J.
AU - Bitter, Wilbert
T1 - PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5.
JO - Molecular Microbiology
JF - Molecular Microbiology
Y1 - 2009/08//
VL - 73
IS - 3
M3 - Article
SP - 329
EP - 340
PB - Wiley-Blackwell
SN - 0950382X
AB - ESX-5 is one of the five type VII secretion systems found in mycobacteria. These secretion systems are also known as ESAT-6-like secretion systems. Here, we have determined the secretome of ESX-5 by a proteomic approach in two different strains of Mycobacterium marinum. Comparison of the secretion profile of wild-type strains and their ESX-5 mutants showed that a number of PE_PGRS and PPE-MPTR proteins are dependent on ESX-5 for transport. The PE and PPE protein families are unique to mycobacteria, are highly expanded in several pathogenic species, such as Mycobacterium tuberculosis and M. marinum, and certain family members are cell surface antigens associated with virulence. Using a monoclonal antibody directed against the PGRS domain we showed that nearly all PE_PGRS proteins that are recognized by this antibody are missing in the supernatant of ESX-5 mutants. In addition to PE_PGRS and PPE proteins, the ESX-5 secretion system is responsible for the secretion of a ESAT-6-like proteins. Together, these data show that ESX-5 is probably a major secretion pathway for mycobacteria and that this system is responsible for the secretion of recently evolved PE_PGRS and PPE proteins. [ABSTRACT FROM AUTHOR]
AB - Copyright of Molecular Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MYCOBACTERIUM marinum
KW - PROTEINS -- Research
KW - SECRETION
KW - BIOLOGICAL transport
KW - PROTEOMICS
KW - CELL surface antigens
N1 - Accession Number: 43394107; Abdallah, Abdallah M. 1 Verboom, Theo 1 Weerdenburg, Eveline M. 1 Pittius, Nicolaas C. Gey van 2 Mahasha, Phetole W. 2 Jiménez, Connie 3 Parra, Marcela 4 Cadieux, Nathalie 4 Brennan, Michael J. 4 Appelmelk, Ben J. 1 Bitter, Wilbert 1; Email Address: w.bitter@vumc.nl; Affiliation: 1: Department of Medical Microbiology and Infection Control, Vumc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, the Netherlands 2: DST/NRF Centre of Excellence for Biomedical TB Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences -- Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa 3: OncoProteomics Laboratory, Vumc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, the Netherlands 4: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA; Source Info: Aug2009, Vol. 73 Issue 3, p329; Subject Term: MYCOBACTERIUM marinum; Subject Term: PROTEINS -- Research; Subject Term: SECRETION; Subject Term: BIOLOGICAL transport; Subject Term: PROTEOMICS; Subject Term: CELL surface antigens; Number of Pages: 12p; Illustrations: 6 Black and White Photographs, 3 Charts; Document Type: Article
L3 - 10.1111/j.1365-2958.2009.06783.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rudick, R. A.
AU - Polman, C. H.
AU - Cohen, J. A.
AU - Walton, M. K.
AU - Miller, A. E.
AU - Confavreux, C.
AU - Lublin, F. D.
AU - Hutchinson, M.
AU - O'Connor, P. W.
AU - Schwid, S. R.
AU - Balcer, L. J.
AU - Lynn, F.
AU - Panzara, M. A.
AU - Sandrock, A. W.
T1 - Assessing disability progression with the Multiple Sclerosis Functional Composite.
JO - Multiple Sclerosis (13524585)
JF - Multiple Sclerosis (13524585)
Y1 - 2009/08//
VL - 15
IS - 8
M3 - Article
SP - 984
EP - 997
PB - Sage Publications, Ltd.
SN - 13524585
AB - Background The initial Multiple Sclerosis Functional Composite (MSFC) proposal was a three-part composite of quantitative measures of ambulation, upper extremity function, and cognitive function expressed as a single composite Z-score. However, the clinical meaning of an MSFC Z-score change is not obvious. This study instead used MSFC component data to define a patient-specific disease progression event. Objective Evaluate a new method for analyzing disability progression using the MSFC. Methods MSFC progression was defined as worsening from baseline on scores of at least one MSFC component by 20% (MSFC Progression-20) or 15% (MSFC Progression-15), sustained for ≥3 months. Progression rates were determined using data from natalizumab clinical studies (Natalizumab Safety and Efficacy in Relapsing Remitting Multiple Sclerosis [AFFIRM] and Safety and Efficacy of Natalizumab in Combination With Interferon Beta-1a in Patients With Relapsing Remitting Multiple Sclerosis [SENTINEL]). Correlations between MSFC progression and other clinical measures were determined, as was sensitivity to treatment effects. Results Substantial numbers of patients met MSFC progression criteria, with MSFC Progression-15 being more sensitive than MSFC Progression-20, at both 1 and 2 years. MSFC Progression-20 and MSFC Progression-15 were related significantly to Expanded Disability Status Scale (EDSS) score change, relapse rate, and the SF-36 Physical Component Summary (PCS) score change. MSFC Progression-20 and MSFC Progression-15 at 1 year were predictive of EDSS progression at 2 years. Both MSFC progression end points demonstrated treatment effects in AFFIRM, and results were replicated in SENTINEL. Conclusion MSFC Progression-20 and MSFC Progression-15 are sensitive measures of disability progression; correlate with EDSS, relapse rates, and SF-36 PCS; and are capable of demonstrating therapeutic effects in randomized, controlled clinical studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Multiple Sclerosis (13524585) is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MULTIPLE sclerosis
KW - DEVELOPMENTAL disabilities
KW - MYELIN sheath -- Diseases
KW - VIRUS diseases
KW - ANTINEOPLASTIC agents
KW - GLYCOPROTEINS
KW - clinical end points
KW - disability progression
KW - multiple sclerosis
KW - Multiple Sclerosis Functional Composite
KW - natalizumab
KW - relapsing-remitting
N1 - Accession Number: 43798634; Rudick, R. A. 1; Email Address: rudickr@ccf.org Polman, C. H. 2 Cohen, J. A. 1 Walton, M. K. 3 Miller, A. E. 4 Confavreux, C. 5 Lublin, F. D. 4 Hutchinson, M. 6 O'Connor, P. W. 7 Schwid, S. R. Balcer, L. J. 8 Lynn, F. 9 Panzara, M. A. 9 Sandrock, A. W. 9; Affiliation: 1: Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, USA 2: Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands 3: Center for Drug Evaluation and Research, United States Food and Drug Administration, Washington, DC, USA 4: Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA 5: Hôpital Neurologique, Lyon, France 6: St. Vincent's University Hospital, Dublin, Ireland 7: St. Michael's Hospital, Toronto, Ontario, Canada 8: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA 9: Biogen Idec, Inc., Cambridge, Massachusetts, USA; Source Info: Aug2009, Vol. 15 Issue 8, p984; Subject Term: MULTIPLE sclerosis; Subject Term: DEVELOPMENTAL disabilities; Subject Term: MYELIN sheath -- Diseases; Subject Term: VIRUS diseases; Subject Term: ANTINEOPLASTIC agents; Subject Term: GLYCOPROTEINS; Author-Supplied Keyword: clinical end points; Author-Supplied Keyword: disability progression; Author-Supplied Keyword: multiple sclerosis; Author-Supplied Keyword: Multiple Sclerosis Functional Composite; Author-Supplied Keyword: natalizumab; Author-Supplied Keyword: relapsing-remitting; Number of Pages: 14p; Illustrations: 5 Charts, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Murashov, Vladimir
AU - Howard, John
T1 - Essential features for proactive risk management.
JO - Nature Nanotechnology
JF - Nature Nanotechnology
Y1 - 2009/08//
VL - 4
IS - 8
M3 - Opinion
SP - 467
EP - 470
SN - 17483387
AB - The author describes the essential features of a proactive approach to the management of occupational health risks in emerging technologies. The author explores the concept of qualitative approach to risk assessment. The author also talks about the importance of periodically reassessing the occupational risk profile as an adaptive strategy. The author also discusses the establishment of Globally Harmonized Systems of risk management for all technologies.
KW - RISK management in business
KW - INDUSTRIAL hygiene
KW - HIGH technology industries
KW - RISK assessment
KW - QUALITATIVE research
N1 - Accession Number: 43578750; Murashov, Vladimir 1; Email Address: vladimir.murashov@cdc.hhs.gov Howard, John 2; Affiliation: 1: National Institute for Occupational Safety and Health, US Department of Health and Human Services, 395 E Street S.W., Suite 9200, Washington DC 20201, USA 2: Centers for Disease Control and Prevention, US Department of Health and Human Services, 395 E Street S.W., Suite 9200, Washington DC 20201, USA; Source Info: Aug2009, Vol. 4 Issue 8, p467; Subject Term: RISK management in business; Subject Term: INDUSTRIAL hygiene; Subject Term: HIGH technology industries; Subject Term: RISK assessment; Subject Term: QUALITATIVE research; Number of Pages: 4p; Document Type: Opinion
L3 - 10.1038/nnano.2009.205
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
T1 - Childhood Overweight Prevalence in the United States: The Impact of Parent-reported Height and Weight.
AU - Akinbami, Lara J.
AU - Ogden, Cynthia L.
JO - Obesity (19307381)
JF - Obesity (19307381)
Y1 - 2009/08//
VL - 17
IS - 8
SP - 1574
EP - 1580
SN - 19307381
N1 - Accession Number: 43407343; Author: Akinbami, Lara J.: 1,2 email: lakinbami@cdc.gov. Author: Ogden, Cynthia L.: 3 ; Author Affiliation: 1 Infant, Child and Women's Health Statistics Branch, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA: 2 US Public Health Service, Rockville, Maryland, USA: 3 Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA; No. of Pages: 7; Language: English; Publication Type: Article; Update Code: 20090728
N2 - Parent-reported height and weight are often used to estimate BMI and overweight status among children. The quality of parent-reported data has not been compared to measured data on a national scale for all race/ethnic groups in the United States. Parent-reported height and weight for 2–17-year-old children in two national health interview surveys—the 1999–2004 National Health Interview Survey (NHIS) and the 2003–2004 National Survey of Children's Health (NSCH)—were compared to measured values from a national examination survey—the 1999–2004 National Health and Nutrition Examination Survey (NHANES). Compared to measured data, parent-reported data overestimated childhood overweight in both interview surveys. For example, overweight prevalence among 2–17-year-olds was 25% (s.e. 0.2) using parent-reported NHIS data vs. 16% (s.e. 0.6) using measured NHANES data. Parent-reported data overestimated overweight among younger children, but underestimated overweight among older children. The discrepancy between reported and measured estimates arose mainly from reported height among very young children. For children aged 2–11 years, the mean reported height from NHIS was 3–6 cm less than mean measured height from NHANES (P < 0.001) vs. no difference among children aged 16–17 years. Measured data remains the gold standard for surveillance of childhood overweight. Although this analysis compared mean values from survey populations rather than parent-reported and measured data for individuals, the results from nationally representative data reinforce previous recommendations based on small samples that parent-reported data should not be used to estimate overweight prevalence among preschool and elementary school–aged children.Obesity (2009) 17 8, 1574–1580. 10.1038/oby.2009.1 ABSTRACT FROM AUTHOR
KW - *STATURE
KW - *BODY weight
KW - *OBESITY in children
KW - *SCHOOL children
KW - *HEALTH
KW - ETHNIC groups
KW - UNITED States
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Yessika Mashinsky
AU - R. Andrew Thompson
AU - Ozgur Koru
AU - Alexandre daSilva
T1 - Human zoonotic enteropathogens in a constructed free-surface flow wetland.
JO - Parasitology Research
JF - Parasitology Research
Y1 - 2009/08//
VL - 105
IS - 2
M3 - Article
SP - 423
EP - 428
SN - 09320113
AB - Abstract Effluents from a small-scale free-surface flow constructed wetland, used for polishing of secondary treated wastewater, contained significantly higher concentrations of potentially viable Giardia duodenalis cysts and Enterocytozoon bieneusi spores than did wetland influents consisting of secondary treated wastewater. Zoonotic Assemblage A of G. duodenalis cysts was identified in wetland inflows, while Assemblage A and two nonhuman infective Assemblages (i.e., C, and E) were present in wetland effluents. E. bieneusi spores represented genotype K based on DNA sequencing analysis of internal transcribed spacer. The study demonstrated that: (1) free-surface flow small-scale constructed wetlands may not provide sufficient remediation for human zoonotic protozoa and fungi present in secondary treated wastewater; (2) dogs and livestock can substantially contribute human-pathogenic protozoan and fungal microorganisms to engineered vegetated wetland systems; and (3) large volumes of wetland effluents can contribute to contamination of surface waters used for recreation and drinking water abstraction and therefore represent a serious public health threat. [ABSTRACT FROM AUTHOR]
AB - Copyright of Parasitology Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ZOONOSES
KW - MICROORGANISMS
KW - WETLAND ecology
KW - CONSTRUCTED wetlands
KW - GIARDIA
KW - NUCLEOTIDE sequence
N1 - Accession Number: 42423487; Yessika Mashinsky 1 R. Andrew Thompson 2 Ozgur Koru 3 Alexandre daSilva 3; Affiliation: 1: Johns Hopkins Bloomberg School of Public Health Department of Environmental Health Sciences, Division of Environmental Health Engineering Baltimore MD 21205 USA 2: Murdoch University WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences Murdoch Western Australia 6150 Australia 3: U.S. Department of Health and Public Services Division of Parasitic Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service Atlanta GA 30341 USA; Source Info: Aug2009, Vol. 105 Issue 2, p423; Subject Term: ZOONOSES; Subject Term: MICROORGANISMS; Subject Term: WETLAND ecology; Subject Term: CONSTRUCTED wetlands; Subject Term: GIARDIA; Subject Term: NUCLEOTIDE sequence; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105221738
T1 - Provider-patient interaction in rural Cameroon--how it relates to the patient's understanding of diagnosis and prescribed drugs, the patient's concept of illness, and access to therapy.
AU - Labhardt ND
AU - Schiess K
AU - Manga E
AU - Langewitz W
Y1 - 2009/08//
N1 - Accession Number: 105221738. Language: English. Entry Date: 20101015. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Core Nursing; Europe; Health Promotion/Education; Nursing; Peer Reviewed; UK & Ireland. NLM UID: 8406280.
KW - Health Behavior
KW - Attitude to Health
KW - Health Services Accessibility
KW - Patient Education -- Statistics and Numerical Data
KW - Drugs, Prescription
KW - Primary Health Care -- Statistics and Numerical Data
KW - Professional-Patient Relations
KW - Rural Population
KW - Adolescence
KW - Adult
KW - Aged
KW - Analysis of Variance
KW - Cameroon
KW - Child
KW - Communication
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Female
KW - Surveys
KW - Human
KW - Male
KW - Middle Age
KW - Questionnaires
KW - Referral and Consultation
KW - Audiorecording
KW - Young Adult
SP - 196
EP - 201
JO - Patient Education & Counseling
JF - Patient Education & Counseling
JA - PATIENT EDUC COUNS
VL - 76
IS - 2
PB - Elsevier Science
AB - OBJECTIVE: This cross-sectional survey examines the relation between provider-patient interaction and several patient-outcomes in a rural health district in Cameroon. METHODS: We used structured patient interviews and the Roter Interaction Analysis System (RIAS) for analysis of audio-recorded consultations. RESULTS: Data from 130 primary care consultations with 13 health-care providers were analysed. 51% of patients correctly named their diagnoses after the consultation; in 47% of prescribed drugs patients explained correctly the purpose. Patients' ability to recall diagnoses was related to the extent of clarity a provider used in mentioning it during consultation (recall rates: 87.5% if mentioned explicitly, 56.7% if mentioned indirectly and 19.2% if not mentioned at all; p<0.001). Two thirds of patients were able to describe their concept of illness before the consultation, but only 47% of them mentioned it during consultations. On average patients who mentioned their disease concept were faced with more remarks of disapproval from providers (1.73 vs 0.63 per consultation; p<0.01). Although 41% of patients admitted problems with financial resources to buy prescribed drugs, discussion about financial issues was very rare during consultations. Providers issued financial questions in 32%, patients in 21% of consultations. CONCLUSION: This study shows that provider-patient interaction in primary health care in a rural Cameroon district deserves more attention. It might improve the patients' knowledge about their health condition and support them in beneficial health behaviour. PRACTICE IMPLICATIONS: Our findings should encourage providers to give more medical explanation, to discuss patients' health beliefs in a non-judgmental manner, and to consider financial issues more carefully.
SN - 0738-3991
AD - Office of the Surgeon General Basel-Stadt, Health Department Basel-Stadt, Switzerland. niklaus.labhardt@gmail.com
U2 - PMID: 19168317.
DO - 10.1016/j.pec.2008.12.020
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tawakkul, Mobin A.
AU - Shah, Rakhi B.
AU - Zidan, Ahmed
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
T1 - Complexation of risperidone with a taste-masking resin: Novel application of near infra-red and chemical imaging to evaluate complexes.
JO - Pharmaceutical Development & Technology
JF - Pharmaceutical Development & Technology
Y1 - 2009/08//
VL - 14
IS - 4
M3 - Article
SP - 409
EP - 421
PB - Taylor & Francis Ltd
SN - 10837450
AB - The purpose of the study was to investigate the complexation between a weakly basic drug (risperidone) and an ion exchange resin (amberlite IRP-64) used as a taste-masking agent via two preparation methods: physical mixture and solvent evaporation. Both methods were prepared in different drug-to-resin ratios by weight (1:1, 1:2, 1:4, 1:6). Physicochemical characterizations were performed using differential scanning calorimetry, x-ray diffraction, infra-red spectroscopy, Raman spectroscopy, near infra-red spectroscopy, chemical imaging and drug release studies. These physicochemical techniques revealed that risperidone formed complex with the resin via the solvent evaporation method where enhanced dissolution occurred but not with the physical mixtures. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Development & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RISPERIDONE
KW - ION exchange (Chemistry)
KW - SOLVENTS
KW - EVAPORATION (Chemistry)
KW - CALORIMETRY
KW - X-ray diffraction
KW - amberlite
KW - calorimetry (DSC)
KW - characterization
KW - chemical imaging
KW - complexation
KW - drug release
KW - FTIR
KW - near infra-red spectroscopy
KW - Polacrilex
KW - raman spectroscopy
KW - x-ray diffractometry
N1 - Accession Number: 43539145; Tawakkul, Mobin A. 1; Shah, Rakhi B. 1; Zidan, Ahmed 1; Sayeed, Vilayat A. 2; Khan, Mansoor A. 1; Email Address: Mansoor.khan@fda.hhs.gov; Affiliations: 1: Division of Product Quality Research/Office of Testing and Research, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Silver Spring, Maryland, USA; 2: Office of Generic Drugs Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Silver Spring, Maryland, USA; Issue Info: Aug2009, Vol. 14 Issue 4, p409; Subject Term: RISPERIDONE; Subject Term: ION exchange (Chemistry); Subject Term: SOLVENTS; Subject Term: EVAPORATION (Chemistry); Subject Term: CALORIMETRY; Subject Term: X-ray diffraction; Author-Supplied Keyword: amberlite; Author-Supplied Keyword: calorimetry (DSC); Author-Supplied Keyword: characterization; Author-Supplied Keyword: chemical imaging; Author-Supplied Keyword: complexation; Author-Supplied Keyword: drug release; Author-Supplied Keyword: FTIR; Author-Supplied Keyword: near infra-red spectroscopy; Author-Supplied Keyword: Polacrilex; Author-Supplied Keyword: raman spectroscopy; Author-Supplied Keyword: x-ray diffractometry; NAICS/Industry Codes: 324110 Petroleum Refineries; Number of Pages: 13p; Illustrations: 1 Diagram, 1 Chart, 9 Graphs; Document Type: Article
L3 - 10.1080/10837450802712666
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Miller, Sharon A.
AU - Beer, Janusz Z.
AU - Savalia, Varsha
T1 - Commentary on ‘Indoor tanning injuries: an evaluation of FDA adverse event reporting data’.
JO - Photodermatology, Photoimmunology & Photomedicine
JF - Photodermatology, Photoimmunology & Photomedicine
Y1 - 2009/08//
VL - 25
IS - 4
M3 - Article
SP - 223
EP - 224
PB - Wiley-Blackwell
SN - 09054383
AB - The authors comments on the paper "Indoor Tanning Injuries: An Evaluation of Food and Drug Administration's (FDA) Adverse Event Reporting Data," by John C. Dowdy and colleagues. Manufacturing standards and guidelines were issued by FDA to assure safety to workers engaging in indoor tanning so that they do not incur serious acute injury to their eyes and skin. The authors say that Dowdy has chosen to examine data on acute injuries taken from FDA and Consumer Product Safety Commission databases.
KW - TANNING salons
KW - INDUSTRIAL safety
KW - SOLAR radiation -- Physiological effect
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - DOWDY, John C.
N1 - Accession Number: 43112400; Miller, Sharon A. 1; Email Address: SharonA.Miller@fda.hhs.gov Beer, Janusz Z. 1 Savalia, Varsha 1; Affiliation: 1: US Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA.; Source Info: Aug2009, Vol. 25 Issue 4, p223; Subject Term: TANNING salons; Subject Term: INDUSTRIAL safety; Subject Term: SOLAR radiation -- Physiological effect; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 812199 Other Personal Care Services; NAICS/Industry Codes: 812190 Other personal care services; People: DOWDY, John C.; Number of Pages: 2p; Document Type: Article
L3 - 10.1111/j.1600-0781.2009.00445.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Oakley, Miranda S.
AU - Majam, Victoria
AU - Mahajan, Babita
AU - Gerald, Noel
AU - Anantharaman, Vivek
AU - Ward, Jerrold M.
AU - Faucette, Lawrence J.
AU - McCutchan, Thomas F.
AU - Hong Zheng
AU - Terabe, Masaki
AU - Berzofsky, Jay A.
AU - Aravind, L.
AU - Kumar, Sanjai
T1 - Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/08//
VL - 4
IS - 8
M3 - Article
SP - 1
EP - 10
PB - Public Library of Science
SN - 19326203
AB - An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and therapeutics. Genome-wide transcriptional profiling of the brain tissue during experimental cerebral malaria (ECM ) caused by Plasmodium berghei ANKA parasites in mice, a well established surrogate of human cerebral malaria, has been useful in predicting the functional classes of genes involved and pathways altered during the course of disease. To further understand the contribution of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules - CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM. We find that CD14 plays a predominant role in the induction of ECM and regulation of parasite density; deletion of the CD14 gene not only prevented the onset of disease in a majority of susceptible mice (only 21% of CD14-deficient compared to 80% of wildtype mice developed ECM, p<0.0004) but also had an ameliorating effect on parasitemia (a 2 fold reduction during the cerebral phase). Furthermore, deletion of the galectin-3 gene in susceptible C57BL/6 mice resulted in partial protection from ECM (47% of galectin-3-deficient versus 93% of wildtype mice developed ECM, p<0.0073). Subsequent adherence assays suggest that galectin-3 induced pathogenesis of ECM is not mediated by the recognition and binding of galectin-3 to P. berghei ANKA parasites. A previous study of ECM has demonstrated that brain infiltrating T cells are strongly activated and are CD44+CD62L- differentiated memory T cells [1]. We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4+ and CD8+ T cells accumulated in the brain vasculature is approximately equal. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL medicine
KW - PATHOGENIC bacteria
KW - MALARIA
KW - BRAIN diseases
KW - PROTOZOAN diseases
KW - BLOOD-vessels
KW - PLASMODIIDAE
KW - LYMPHOCYTES
KW - RODENTS
KW - T cells
KW - GENES
KW - HEREDITY
N1 - Accession Number: 57426678; Oakley, Miranda S. 1 Majam, Victoria 2 Mahajan, Babita 2 Gerald, Noel 2 Anantharaman, Vivek 3 Ward, Jerrold M. 4 Faucette, Lawrence J. 4 McCutchan, Thomas F. 5 Hong Zheng 2 Terabe, Masaki 6 Berzofsky, Jay A. 6 Aravind, L. 3 Kumar, Sanjai 2; Email Address: sanjai.kumar@fda.hhs.gov; Affiliation: 1: Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, Maryland, United States of America. 2: Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics and Evaluation Research, Food and Drug Administration, Rockville, Maryland, United States of America. 3: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America. 4: Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America. 5: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America. 6: Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.; Source Info: 2009, Vol. 4 Issue 8, p1; Subject Term: CLINICAL medicine; Subject Term: PATHOGENIC bacteria; Subject Term: MALARIA; Subject Term: BRAIN diseases; Subject Term: PROTOZOAN diseases; Subject Term: BLOOD-vessels; Subject Term: PLASMODIIDAE; Subject Term: LYMPHOCYTES; Subject Term: RODENTS; Subject Term: T cells; Subject Term: GENES; Subject Term: HEREDITY; NAICS/Industry Codes: 112999 All other miscellaneous animal production; Number of Pages: 10p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 3 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0006793
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Osorio, Jorge E.
AU - Iams, Keith P.
AU - Meteyer, Carol U.
AU - Rocke, Tonie E.
T1 - Comparison of Monkeypox Viruses Pathogenesis in Mice by In Vivo Imaging.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/08//
VL - 4
IS - 8
M3 - Article
SP - 1
EP - 10
PB - Public Library of Science
SN - 19326203
AB - Monkeypox viruses (MPXV) cause human monkeypox, a zoonotic smallpox-like disease endemic to Africa, and are of worldwide public health and biodefense concern. Using viruses from the Congo (MPXV-2003-Congo-358) and West African (MPXV-2003-USA-044) clades, we constructed recombinant viruses that express the luciferase gene (MPXV-Congo/Luc+and MPXV-USA-Luc+) and compared their viral infection in mice by biophotonic imaging. BALB/c mice became infected by both MPXV clades, but they recovered and cleared the infection within 10 days post-infection (PI). However, infection in severe combined immune deficient (SCID) BALB/c mice resulted in 100% lethality. Intraperitoneal (IP) injection of both MPXVCongo and MPXV-Congo/Luc+resulted in a systemic clinical disease and the same mean time-to-death at 9 (±0) days postinfection. Likewise, IP injection of SCID-BALB/c mice with MPXV-USA or the MPXV-USA-Luc+, resulted in similar disease but longer (P<0.05) mean time-to-death (11±0 days) for both viruses compared to the Congo strains. Imaging studies in SCID mice showed luminescence in the abdomen within 24 hours PI with subsequent spread elsewhere. Animals infected with the MPXV-USA/Luc+had less intense luminescence in tissues than those inoculated with MPXV-Congo/Luc+, and systemic spread of the MPXV-USA/Luc+virus occurred approximately two days later than the MPXV-Congo/Luc+. The ovary was an important target for viral replication as evidenced by the high viral titers and immunohistochemistry. These studies demonstrate the suitability of a mouse model and biophotonic imaging to compare the disease progression and tissue tropism of MPX viruses. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MONKEYPOX virus
KW - HUMAN monkeypox
KW - ZOONOSES
KW - IMAGING systems in medicine
KW - SEVERE combined immunodeficiency
KW - BIOSECURITY
KW - BIOPHOTOMETRY
KW - IMMUNOHISTOCHEMISTRY
KW - AFRICA
KW - UNITED States
N1 - Accession Number: 57426483; Osorio, Jorge E. 1; Email Address: osorio@svm.vetmed.wisc.edu Iams, Keith P. 2 Meteyer, Carol U. 3 Rocke, Tonie E. 3; Affiliation: 1: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America. 2: Food and Drug Administration, Pacific Regional Lab - Southwest, Irvine, California, United States of America. 3: U. S. Geological Survey- National Wildlife Health Center, Madison, Wisconsin, United States of America.; Source Info: 2009, Vol. 4 Issue 8, p1; Subject Term: MONKEYPOX virus; Subject Term: HUMAN monkeypox; Subject Term: ZOONOSES; Subject Term: IMAGING systems in medicine; Subject Term: SEVERE combined immunodeficiency; Subject Term: BIOSECURITY; Subject Term: BIOPHOTOMETRY; Subject Term: IMMUNOHISTOCHEMISTRY; Subject Term: AFRICA; Subject Term: UNITED States; Number of Pages: 10p; Illustrations: 2 Color Photographs, 3 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0006592
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sauna, Zuben E.
AU - Okunji, Chinyere
AU - Hunt, Ryan C.
AU - Gupta, Tanvi
AU - Allen, Courtni E.
AU - Plum, Elizabeth
AU - Blaisdell, Adam
AU - Grigoryan, Vahan
AU - Geetha, S.
AU - Fathke, Robert
AU - Soejima, Kenji
AU - Kimchi-Sarfaty, Chava
T1 - Characterization of Conformation-Sensitive Antibodies to ADAMTS13, the von Willebrand Cleavage Protease.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/08//
VL - 4
IS - 8
M3 - Article
SP - 1
EP - 10
PB - Public Library of Science
SN - 19326203
AB - Background: The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis. Understanding the mechanism of this protein is an important goal. Conformation sensitive antibodies have been used to monitor protein conformation and to decipher the molecular mechanism of proteins as well as to distinguish functional and non-functional mutants. Methodology/Principal Findings: We have characterized several antibodies against ADAMTS13, both monoclonal and polyclonal. We have used flow cytometry to estimate the binding of these antibodies to ADAMTS13 and demonstrate that antibodies raised against the TSP and disintegrin domains detect conformation changes in the ADAMTS13. Thus for example, increased binding of these antibodies was detected in the presence of the substrate (VWF), mainly at 37°C and not at 4°C. These antibodies could also detect differences between wild-type ADAMTS13 and the catalytically deficient mutant (P475S). The flow cytometry approach also allows us to estimate the reactivity of the antibody as well as its apparent affinity. Conclusions/Significance: Our results suggest that these antibodies may serve as useful reagents to distinguish functional and non-functional ADAMTS13 and analyze conformational transitions to understand the catalytic mechanism. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEOLYTIC enzymes
KW - METALLOPROTEINASES
KW - VON Willebrand factor
KW - THROMBOTIC thrombocytopenic purpura
KW - PROTEINS
KW - BIOMOLECULES
KW - ORGANIC compounds
KW - IMMUNOGLOBULINS
KW - MONOCLONAL antibodies
N1 - Accession Number: 57426400; Sauna, Zuben E. 1; Email Address: Zuben.sauna@fda.hhs.gov Okunji, Chinyere 1 Hunt, Ryan C. 1 Gupta, Tanvi 1 Allen, Courtni E. 1 Plum, Elizabeth 1 Blaisdell, Adam 1 Grigoryan, Vahan 2 Geetha, S. 1 Fathke, Robert 1 Soejima, Kenji 3 Kimchi-Sarfaty, Chava 1; Email Address: Chava.kimchi-sarfaty@fda.hhs.gov; Affiliation: 1: Laboratory of Hemostasis, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America. 2: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America. 3: First Research Department, Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan.; Source Info: 2009, Vol. 4 Issue 8, p1; Subject Term: PROTEOLYTIC enzymes; Subject Term: METALLOPROTEINASES; Subject Term: VON Willebrand factor; Subject Term: THROMBOTIC thrombocytopenic purpura; Subject Term: PROTEINS; Subject Term: BIOMOLECULES; Subject Term: ORGANIC compounds; Subject Term: IMMUNOGLOBULINS; Subject Term: MONOCLONAL antibodies; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 10p; Illustrations: 8 Graphs; Document Type: Article
L3 - 10.1371/journal.pone.0006506
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chiesa, Oscar Alberto
AU - von Bredow, Jurgen
AU - Smith, Michelle
AU - Thomas, Michael
T1 - One-port video assisted laparoscopic kidney biopsy in standing steers
JO - Research in Veterinary Science
JF - Research in Veterinary Science
Y1 - 2009/08//
VL - 87
IS - 1
M3 - Article
SP - 133
EP - 134
SN - 00345288
AB - Abstract: The purpose of this study was to simplify the two-port laparoscopic renal biopsy technique used in support of pharmacokinetic studies through the application of a one-port system. Twelve Holstein steers were fasted for 24h and sedated with acepromazine and xylaxine in preparation for laparoscopic surgery in standing stocks. Lidocaine 2% was injected to provide local anesthesia for introduction of the trocar-cannula assembly. The operating endoscope was inserted and the abdomen was insufflated with CO2. A biopsy forceps was introduced into the channel of the operating endoscope to obtain a 100mg kidney cortex sample. Eighteen laparoscopic procedures provided 18 kidney samples suitable for pharmacokinetic studies. No complications were encountered. The one-port laparoscopic kidney biopsy is feasible and safe, and advanced skill required for triangulation is not necessary for its performance. [Copyright &y& Elsevier]
AB - Copyright of Research in Veterinary Science is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VETERINARY diagnosis
KW - VETERINARY biopsy
KW - BEEF cattle
KW - KIDNEY cortex
KW - VETERINARY laparoscopic surgery
KW - LOCAL anesthetics
KW - ACEPROMAZINE
KW - ANIMAL sedation
KW - Biopsy
KW - Cattle
KW - Kidney
KW - Laparoscopy
KW - One-port
KW - Standing
N1 - Accession Number: 39777724; Chiesa, Oscar Alberto; Email Address: oscar.chiesa@fda.hhs.gov von Bredow, Jurgen 1 Smith, Michelle 1 Thomas, Michael 1; Affiliation: 1: Center for Veterinary Medicine, Office of Research, Division of Residue Chemistry, Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, United States; Source Info: Aug2009, Vol. 87 Issue 1, p133; Subject Term: VETERINARY diagnosis; Subject Term: VETERINARY biopsy; Subject Term: BEEF cattle; Subject Term: KIDNEY cortex; Subject Term: VETERINARY laparoscopic surgery; Subject Term: LOCAL anesthetics; Subject Term: ACEPROMAZINE; Subject Term: ANIMAL sedation; Author-Supplied Keyword: Biopsy; Author-Supplied Keyword: Cattle; Author-Supplied Keyword: Kidney; Author-Supplied Keyword: Laparoscopy; Author-Supplied Keyword: One-port; Author-Supplied Keyword: Standing; NAICS/Industry Codes: 112110 Beef cattle ranching and farming, including feedlots; NAICS/Industry Codes: 112111 Beef Cattle Ranching and Farming; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 2p; Document Type: Article
L3 - 10.1016/j.rvsc.2008.10.016
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van der Helm, Jannie J.
AU - Hoebe, Christian J. P. A.
AU - van Rootjen, Martijn S.
AU - Brouwers, Elfi E. H. G.
AU - Fennema, Han S. A.
AU - Thiesbrummel, Harold F. J.
AU - Dukers-Muijrers, Nicole H. T. M.
T1 - High Performance and Acceptability of Self-Collected Rectal Swabs for Diagnosis of Chiamydia trachomatis and Neisseria gonorrhoeae in Men Who Have Sex With Men and Women.
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
Y1 - 2009/08//
VL - 36
IS - 8
M3 - Article
SP - 493
EP - 497
SN - 01485717
AB - The article presents a study which evaluates the validity and acceptability of self-collected rectal swabs (SRS) in diagnosing Chlamydia trachomatis (CT) and Neisseria gonnorrhoeae (NG) in men who have sex with men (MSM) and women. A standard provider-collected rectal swab (PRS) and SRS were both tested for CT and NG using a nucleic acid amplification tests. Results reveal a need for rectal screening in sexually transmitted infection (STI) consultation, and that SRS is useful in diagnosing STIs.
KW - Chlamydia trachomatis
KW - DISEASES
KW - Sexually transmitted diseases -- Diagnosis
KW - Neisseria gonorrhoeae
KW - Medical screening
KW - Men
N1 - Accession Number: 43693384; van der Helm, Jannie J. 1; Email Address: jvdhelm@ggd.amsterdam.nl; Hoebe, Christian J. P. A. 2,3; van Rootjen, Martijn S. 1; Brouwers, Elfi E. H. G. 2,3; Fennema, Han S. A. 4; Thiesbrummel, Harold F. J. 1; Dukers-Muijrers, Nicole H. T. M. 1,2,3; Affiliations: 1: Cluster Infectious Diseases, Sexually Transmitted Infection Outpatient Clinic, Amsterdam Public Health Service, Amsterdam, Netherlands; 2: Department of Infectious Diseases, South Limburg Public Health Service, Geleen, Netherlands; 3: Department of Medical Microbiology, Maastricht Infection Center, Maastricht University Medical Centre, Maastricht, Netherlands; 4: Cluster Infectious Diseases, Amsterdam Public Health Service, Amsterdam, Netherlands; Issue Info: Aug2009, Vol. 36 Issue 8, p493; Thesaurus Term: Chlamydia trachomatis; Thesaurus Term: DISEASES; Subject Term: Sexually transmitted diseases -- Diagnosis; Subject Term: Neisseria gonorrhoeae; Subject Term: Medical screening; Subject Term: Men; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1097/OLQ.0b013e3181a44b8c
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105388846
T1 - High performance and acceptability of self-collected rectal swabs for diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in men who have sex with men and women.
AU - van der Helm JJ
AU - Hoebe CJ
AU - van Rooijen MS
AU - Brouwers EE
AU - Fennema HS
AU - Thiesbrummel HF
AU - Dukers-Muijrers NH
Y1 - 2009/08//
N1 - Accession Number: 105388846. Language: English. Entry Date: 20091009. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 7705941.
KW - Chlamydia Trachomatis
KW - Neisseria
KW - Rectum -- Microbiology
KW - Self Care -- Statistics and Numerical Data
KW - Specimen Handling -- Methods
KW - Chlamydia Infections -- Diagnosis
KW - Chlamydia Infections -- Epidemiology
KW - Chlamydia Infections -- Microbiology
KW - Female
KW - Gonorrhea -- Diagnosis
KW - Gonorrhea -- Epidemiology
KW - Gonorrhea -- Microbiology
KW - Heterosexuality
KW - Homosexuality
KW - Male
KW - Nucleic Acid Amplification Techniques
KW - Patient Attitudes
KW - Prevalence
KW - Questionnaires
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Sexuality
KW - Sexually Transmitted Diseases -- Diagnosis
KW - Sexually Transmitted Diseases -- Epidemiology
KW - Sexually Transmitted Diseases -- Microbiology
KW - Human
SP - 493
EP - 497
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
JA - SEX TRANSM DIS
VL - 36
IS - 8
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0148-5717
AD - Cluster Infectious Diseases, Sexually Transmitted Infection Outpatient Clinic, Amsterdam Public Health Service, Weesperplein 1, Amsterdam 1018WZ, The Netherlands. jvdhelm@ggd.amsterdam.nl
U2 - PMID: 19617869.
DO - 10.1097/OLQ.0b013e3181a44b8c
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kirby, James B.
AU - Bollen, Kenneth A.
T1 - USING INSTRUMENTAL VARIABLE TESTS TO EVALUATE MODEL SPECIFICATION IN LATENT VARIABLE STRUCTURAL EQUATION MODELS.
JO - Sociological Methodology
JF - Sociological Methodology
Y1 - 2009/08//
VL - 39
IS - 1
M3 - Article
SP - 327
EP - 355
SN - 00811750
AB - Structural equation modeling (SEM) with latent variables is a powerful tool for social and behavioral scientists, combining many of the strengths of psychometrics and econometrics into a single framework. The most common estimator for SEM is the full-information maximum likelihood (ML) estimator, but there is continuing interest in limited information estimators because of their distributional robustness and their greater resistance to structural specification errors. However, the literature discussing model fit for limited information estimators for latent variable models is sparse compared with that for full-information estimators. We address this shortcoming by providing several specification tests based on the 2SLS estimator for latent variable structural equation models developed by Bollen (1996). We explain how these tests can be used not only to identify a misspecified model but to help diagnose the source of misspecification within a model. We present and discuss results from a Monte Carlo experiment designed to evaluate the finite sample properties of these tests. Our findings suggest that the 2SLS tests successfully identify most misspecified models, even those with modest misspecification, and that they provide researchers with information that can help diagnose the source of misspecification. [ABSTRACT FROM AUTHOR]
AB - Copyright of Sociological Methodology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSTRUMENTAL variables (Statistics)
KW - STRUCTURAL equation modeling
KW - LATENT variables
KW - MAXIMUM likelihood statistics
KW - ROBUST statistics
KW - MONTE Carlo method
KW - ERROR analysis (Mathematics)
N1 - Accession Number: 45278220; Kirby, James B. 1 Bollen, Kenneth A. 2; Affiliation: 1: *Agency for Healthcare Research and Quality 2: University of North Carolina, Chapel Hill; Source Info: 2009, Vol. 39 Issue 1, p327; Subject Term: INSTRUMENTAL variables (Statistics); Subject Term: STRUCTURAL equation modeling; Subject Term: LATENT variables; Subject Term: MAXIMUM likelihood statistics; Subject Term: ROBUST statistics; Subject Term: MONTE Carlo method; Subject Term: ERROR analysis (Mathematics); Number of Pages: 29p; Illustrations: 3 Diagrams, 5 Charts; Document Type: Article
L3 - 10.1111/j.1467-9531.2009.01217.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jun Zhang
AU - Goering, Peter L.
AU - Espandiari, Parvaneh
AU - Shaw, Martin
AU - Bonventre, Joseph V.
AU - Vaidya, Vishal S.
AU - Brown, Ronald P.
AU - Keenan, Joe
AU - Kilty, Cormac G.
AU - Sadrieh, Nakissa
AU - Hanig, Joseph P.
T1 - Differences in Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidneys of Gentamicin-, Cisplatin-, and Valproic Acid-Treated Rats: Potential Role of iNOS and Nitrotyrosine.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2009/08//
VL - 37
IS - 5
M3 - Article
SP - 629
EP - 643
SN - 01926233
AB - The present study compared the immunolocalization of Kim-1, renal papillary antigen (RPA)-1, and RPA-2 with that of inducible nitric oxide synthase (iNOS) and nitrotyrosine in kidneys of gentamicin sulfate (Gen)- and cisplatin (Cis)-treated rats. The specificity of acute kidney injury (AKI) biomarkers, iNOS, and nitrotyrosine was evaluated by dosing rats with valproic acid (VPA). Sprague-Dawley (SD) rats were injected subcutaneously (sc) with 100 mg/kg/day of Gen for six or fourteen days; a single intraperitoneal (ip) dose of 1, 3, or 6 mg/kg of Cis; or 650 mg/kg/day of VPA (ip) for four days. In Gen-treated rats, Kim-1 was expressed in the epithelial cells, mainly in the S1/S2 segments but less so in the S3 segment, and RPA-1 was increased in the epithelial cells of collecting ducts (CD) in the cortex. Spatial expression of iNOS or nitrotyrosine with Kim-1 or RPA-1 was detected. In Cis-treated rats, Kim-1 was expressed only in the S3 segment cells, and RPA-1 and RPA-2 were increased in the epithelial cells of medullary CD or medullary loop of Henle (LH), respectively. Spatial expression of iNOS or nitrotyrosine with RPA-1 or RPA-2 was also identified. These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicologic Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - cisplatin
KW - gentamicin
KW - Kim-1
KW - nitrotyrosine
KW - RPA-1
KW - RPA-2
N1 - Accession Number: 53197553; Jun Zhang 1; Goering, Peter L. 2; Espandiari, Parvaneh 3; Shaw, Martin 4; Bonventre, Joseph V. 5; Vaidya, Vishal S. 5; Brown, Ronald P. 2; Keenan, Joe 4; Kilty, Cormac G. 4; Sadrieh, Nakissa 3; Hanig, Joseph P. 3; Affiliations: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; jun.zhang@fda.hhs.gov; 2: Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA; 3: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; 4: Argutus Medical Ltd., Dublin, Ireland; 5: Harvard Institutes of Medicine, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Issue Info: Aug2009, Vol. 37 Issue 5, p629; Author-Supplied Keyword: cisplatin; Author-Supplied Keyword: gentamicin; Author-Supplied Keyword: Kim-1; Author-Supplied Keyword: nitrotyrosine; Author-Supplied Keyword: RPA-1; Author-Supplied Keyword: RPA-2; Number of Pages: 15p; Document Type: Article; Full Text Word Count: 7854
L3 - 10.1177/0192623309339605
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keenan, Charlotte
AU - Elmore, Susan
AU - Francke-Carroll, Sabine
AU - Kerlin, Roy
AU - Peddada, Shyamal
AU - Pletcher, John
AU - Rinke, Matthias
AU - Schmidt, Stephen Peter
AU - Taylor, Ian
AU - Wolf, Douglas C.
T1 - Potential for a Global Historical Control Database for Proliferative Rodent Lesions.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2009/08//
VL - 37
IS - 5
M3 - Article
SP - 677
EP - 678
SN - 01926233
N1 - Accession Number: 53197543; Keenan, Charlotte 1; Elmore, Susan 2; Francke-Carroll, Sabine 3; Kerlin, Roy 4; Peddada, Shyamal 5; Pletcher, John 6; Rinke, Matthias 7; Schmidt, Stephen Peter 4; Taylor, Ian 8; Wolf, Douglas C. 9; Affiliations: 1: GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA, charlotte.m.keenan@gsk.com; 2: National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA; 3: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA; 4: Pfizer Inc., Groton, Connecticut 06340, USA; 5: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA; 6: Charles River, Frederick, Maryland 21701, USA; 7: Bayer Schering Pharma AG, Wuppertal, Germany; 8: Huntingdon Life Sciences, Eye, Suffolk IP23 7PX, UK; 9: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Issue Info: Aug2009, Vol. 37 Issue 5, p677; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 1553
L3 - 10.1177/0192623309336155
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=53197543&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Keenan, Charlotte
AU - Elmore, Susan
AU - Francke-Carroll, Sabine
AU - Kemp, Ramon
AU - Kerlin, Roy
AU - Peddada, Shyamal
AU - Pletcher, John
AU - Rinke, Matthias
AU - Schmidt, Stephen Peter
AU - Taylor, Ian
AU - Wolf, Douglas C.
T1 - Best Practices for Use of Historical Control Data of Proliferative Rodent Lesions.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2009/08//
VL - 37
IS - 5
M3 - Article
SP - 679
EP - 693
SN - 01926233
KW - best practices
KW - carcinogenicity studies
KW - historical control data
KW - rodent tumors
N1 - Accession Number: 53197542; Keenan, Charlotte 1; Elmore, Susan 2; Francke-Carroll, Sabine 3; Kemp, Ramon 4; Kerlin, Roy 5; Peddada, Shyamal 6; Pletcher, John 7; Rinke, Matthias 8; Schmidt, Stephen Peter 5; Taylor, Ian 9; Wolf, Douglas C. 10; Affiliations: 1: GlaxoSmithKline, King of Prussia, Pennsylvania, USA, charlotte.m.keenan@gsk.com; 2: National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA; 3: Center for Food Safety and Applied Nutrition (CFSAN), U.S. Food and Drug Administration, College Park, Maryland, USA; 4: Merck Research Laboratories, Riom, France; 5: Pfizer Inc., Groton, Connecticut, USA; 6: NIEHS, Research Triangle Park, North Carolina, USA; 7: Charles River, Frederick, Maryland, USA; 8: Bayer Schering Pharma AG, Wuppertal, Germany; 9: Huntingdon Life Sciences, Eye, United Kingdom; 10: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; Issue Info: Aug2009, Vol. 37 Issue 5, p679; Author-Supplied Keyword: best practices; Author-Supplied Keyword: carcinogenicity studies; Author-Supplied Keyword: historical control data; Author-Supplied Keyword: rodent tumors; Number of Pages: 15p; Document Type: Article; Full Text Word Count: 12702
L3 - 10.1177/0192623309336154
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=53197542&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Joseph, Pius
T1 - Mechanisms of cadmium carcinogenesis
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/08//
VL - 238
IS - 3
M3 - Article
SP - 272
EP - 279
SN - 0041008X
AB - Abstract: Cadmium (Cd), a heavy metal of considerable occupational and environmental concern, has been classified as a human carcinogen by the International Agency for Research on Cancer (IARC). The carcinogenic potential of Cd as well as the mechanisms underlying carcinogenesis following exposure to Cd has been studied using in vitro cell culture and in vivo animal models. Exposure of cells to Cd results in their transformation. Administration of Cd in animals results in tumors of multiple organs/tissues. Also, a causal relationship has been noticed between exposure to Cd and the incidence of lung cancer in human. It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CADMIUM poisoning
KW - CARCINOGENS
KW - CELL culture
KW - CARCINOGENESIS -- Animal models
KW - CELL transformation
KW - GENE expression
KW - DNA repair
KW - OXIDATIVE stress
KW - APOPTOSIS
KW - Apoptosis
KW - Cadmium
KW - Carcinogenesis
KW - DNA damage repair
KW - Gene expression
KW - Oxidative stress
N1 - Accession Number: 43301375; Joseph, Pius 1; Email Address: pjoseph1@cdc.gov; Affiliation: 1: Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Aug2009, Vol. 238 Issue 3, p272; Subject Term: CADMIUM poisoning; Subject Term: CARCINOGENS; Subject Term: CELL culture; Subject Term: CARCINOGENESIS -- Animal models; Subject Term: CELL transformation; Subject Term: GENE expression; Subject Term: DNA repair; Subject Term: OXIDATIVE stress; Subject Term: APOPTOSIS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Carcinogenesis; Author-Supplied Keyword: DNA damage repair; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Oxidative stress; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.taap.2009.01.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43301375&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105411095
T1 - Patterns of victimization among male and female inmates: evidence of an enduring legacy.
AU - Wolff N
AU - Shi J
AU - Siegel JA
AU - Wolff, Nancy
AU - Shi, Jing
AU - Siegel, Jane A
Y1 - 2009/08//
N1 - Accession Number: 105411095. Language: English. Entry Date: 20091106. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Biomedical; USA. Grant Information: P20 MH066170-05/MH/NIMH NIH HHS/United States. NLM UID: 8916436.
KW - Child Abuse Survivors -- Statistics and Numerical Data
KW - Crime Victims -- Statistics and Numerical Data
KW - Prisoners -- Statistics and Numerical Data
KW - Sexual Abuse
KW - Adult
KW - Child Abuse Survivors -- Psychosocial Factors
KW - Correctional Facilities
KW - Crime Victims -- Psychosocial Factors
KW - Demography
KW - Female
KW - Male
KW - Middle Age
KW - Prisoners -- Psychosocial Factors
KW - Risk Factors
KW - Sexual Abuse -- Psychosocial Factors
KW - Truth Disclosure
SP - 469
EP - 484
JO - Violence & Victims
JF - Violence & Victims
JA - VIOLENCE VICTIMS
VL - 24
IS - 4
CY - New York, New York
PB - Springer Publishing Company, Inc.
AB - People inside prison have above-average rates of childhood and adult victimization. Little is known, however, about the relationship between types of victimization inside prison and that experienced in childhood. This article estimates rates of victimization for male and female inmates by type of perpetrator and form of victimization (sexual, physical, either, or both) and their association with types of childhood victimization (sexual or physical). Data for these estimates are based on a random sample of approximately 7,500 inmates housed in 12 adult male prisons and one adult female prison in a single state. The significance of the findings for practice are discussed along with recommendations to improve the health and welfare of people inside prison.
SN - 0886-6708
AD - Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ 08901, USA
AD - Center for Mental Health Services and Criminal Justice Research, Rutgers University, New Brunswick, NJ 08901, USA. nwolff@ifh.rutgers.edu
U2 - PMID: 19694352.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105411095&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Thorpe, S. J.
AU - Fox, B.
AU - Sharp, G.
AU - Heath, A. B.
AU - Behr-Gross, M.-E.
AU - Terao, E.
AU - Virata-Theimer, M. L.
AU - Yu, M. W.
T1 - International collaborative study to evaluate candidate reference reagents to standardize haemagglutination testing for anti-A and anti-B in normal intravenous immunoglobulin products.
JO - Vox Sanguinis
JF - Vox Sanguinis
Y1 - 2009/08//
VL - 97
IS - 2
M3 - Article
SP - 160
EP - 168
PB - Wiley-Blackwell
SN - 00429007
AB - Background and Objectives The aim of the study was to evaluate, in an international collaboration, three lyophilized intravenous immunoglobulin (IVIG) preparations for their suitability to standardize and control haemagglutination testing for anti-A and anti-B in IVIG products. Materials and Methods Twenty-three laboratories tested candidate IVIG reference reagents consisting of a Positive control (07/306), a Negative control (07/308), and a specifically formulated Limit preparation (07/310) to define the maximum (e.g. pharmacopoeial) limits of anti-A and anti-B in IVIG products, where limits are applicable. Laboratories performed direct haemagglutination using papain-treated erythrocytes and/or indirect antiglobulin tests. Results For both methods, there was up to 16-fold variation in anti-A and anti-B titres, although there was good agreement over a two-fold titre range for anti-A and anti-B between laboratories for both 07/306 and 07/310 using the direct method. Comparative titration data for 07/306 and 07/310 indicated that the use of a ‘Limit’ reference reagent would facilitate identification of higher titre batches when the direct haemagglutination method is used. Conclusions The establishment of preparations 07/306, 07/308 and 07/310 as reference reagents by the World Health Organization will facilitate global standardization of haemagglutination tests for anti-A and anti-B, ensure that such tests are sufficiently sensitive and specific, and facilitate identification of batches that exceed maximum recommended levels of anti-A and anti-B. The Commission of the European Pharmacopoeia and the United States Food and Drug Administration have adopted the same reference reagents including the maximal specifications defined by preparation 07/310. [ABSTRACT FROM AUTHOR]
AB - Copyright of Vox Sanguinis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD groups
KW - IMMUNOGLOBULINS
KW - AGGLUTINATION of blood
KW - PAPAIN
KW - ERYTHROCYTES
KW - blood group antibodies
KW - haemagglutination
KW - isoagglutinins A and B
KW - IVIG
KW - reference method
KW - specification
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 43112615; Thorpe, S. J. 1; Email Address: susan.thorpe@nibsc.hpa.org.uk Fox, B. 1 Sharp, G. 1 Heath, A. B. 1 Behr-Gross, M.-E. 2 Terao, E. 2 Virata-Theimer, M. L. 3 Yu, M. W. 3; Affiliation: 1: National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK 2: European Directorate for the Quality of Medicines & HealthCare, Council of Europe, Strasbourg, France 3: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA; Source Info: Aug2009, Vol. 97 Issue 2, p160; Subject Term: BLOOD groups; Subject Term: IMMUNOGLOBULINS; Subject Term: AGGLUTINATION of blood; Subject Term: PAPAIN; Subject Term: ERYTHROCYTES; Author-Supplied Keyword: blood group antibodies; Author-Supplied Keyword: haemagglutination; Author-Supplied Keyword: isoagglutinins A and B; Author-Supplied Keyword: IVIG; Author-Supplied Keyword: reference method; Author-Supplied Keyword: specification; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1423-0410.2009.01194.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43112615&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-11053-009
AN - 2009-11053-009
AU - Labhardt, Niklaus Daniel
AU - Schiess, Kaspar
AU - Manga, Engelbert
AU - Langewitz, Wolf
T1 - Provider–patient interaction in rural Cameroon—How it relates to the patient's understanding of diagnosis and prescribed drugs, the patient's concept of illness, and access to therapy.
JF - Patient Education and Counseling
JO - Patient Education and Counseling
JA - Patient Educ Couns
Y1 - 2009/08//
VL - 76
IS - 2
SP - 196
EP - 201
CY - Netherlands
PB - Elsevier Science
SN - 0738-3991
AD - Labhardt, Niklaus Daniel, Gasstrasse 67, CH-4056, Basel, Switzerland
N1 - Accession Number: 2009-11053-009. PMID: 19168317 Partial author list: First Author & Affiliation: Labhardt, Niklaus Daniel; Office of the Surgeon General Basel-Stadt, Health Department Basel-Stadt, Basel, Switzerland. Release Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Attitudes; Diagnosis; Health Care Utilization; Prescription Drugs; Therapeutic Processes. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Cameroon. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Aug, 2009. Publication History: Accepted Date: Dec 12, 2008; Revised Date: Dec 9, 2008; First Submitted Date: Feb 14, 2008. Copyright Statement: Elsevier Ireland Ltd. 2008.
AB - Objective: This cross-sectional survey examines the relation between provider–patient interaction and several patient-outcomes in a rural health district in Cameroon. Methods: We used structured patient interviews and the Roter Interaction Analysis System (RIAS) for analysis of audio-recorded consultations. Results: Data from 130 primary care consultations with 13 health-care providers were analyzed. 51% of patients correctly named their diagnoses after the consultation; in 47% of prescribed drugs patients explained correctly the purpose. Patients’ ability to recall diagnoses was related to the extent of clarity a provider used in mentioning it during consultation (recall rates: 87.5% if mentioned explicitly, 56.7% if mentioned indirectly and 19.2% if not mentioned at all; p < 0.001). Two thirds of patients were able to describe their concept of illness before the consultation, but only 47% of them mentioned it during consultations. On average patients who mentioned their disease concept were faced with more remarks of disapproval from providers (1.73 vs 0.63 per consultation; p < 0.01). Although 41% of patients admitted problems with financial resources to buy prescribed drugs, discussion about financial issues was very rare during consultations. Providers issued financial questions in 32%, patients in 21% of consultations. Conclusion: This study shows that provider–patient interaction in primary health care in a rural Cameroon district deserves more attention. It might improve the patients’ knowledge about their health condition and support them in beneficial health behavior. Practice implications: Our findings should encourage providers to give more medical explanation, to discuss patients’ health beliefs in a non-judgmental manner, and to consider financial issues more carefully. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - provider–patient interaction
KW - diagnosis
KW - prescribed drugs
KW - concept of illness
KW - therapy access
KW - 2009
KW - Client Attitudes
KW - Diagnosis
KW - Health Care Utilization
KW - Prescription Drugs
KW - Therapeutic Processes
KW - 2009
DO - 10.1016/j.pec.2008.12.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11053-009&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0003-3599-1791
UR - niklaus.labhardt@gmail.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08724-010
AN - 2009-08724-010
AU - Singh, Gopal K.
AU - Kogan, Michael D.
AU - Yu, Stella M.
T1 - Disparities in obesity and overweight prevalence among US immigrant children and adolescents by generational status.
JF - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JO - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JA - J Community Health
Y1 - 2009/08//
VL - 34
IS - 4
SP - 271
EP - 281
CY - Germany
PB - Springer
SN - 0094-5145
SN - 1573-3610
AD - Singh, Gopal K., Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2009-08724-010. PMID: 19333745 Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20091221. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Obesity; Overweight. Minor Descriptor: Epidemiology; Ethnic Identity; Racism. Classification: Eating Disorders (3260). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Aug, 2009. Publication History: First Posted Date: Mar 31, 2009. Copyright Statement: Springer Science+Business Media, LLC. 2009.
AB - We examined the prevalence and socio-behavioral correlates of obesity and overweight among 46,707 immigrant and US-born children and adolescents aged 10–17 years. The 2003 National Survey of Children’s Health was used to estimate obesity and overweight prevalence among children in 12 immigrant groups, stratified by race/ethnicity and generational status. Logistic regression was used to examine immigrant differentials in the prevalence and odds of obesity and overweight. Obesity and overweight prevalence varied from a low of 6 and 18% for second-generation Asian immigrants to a high of 24 and 42% for native-born black children (US-born black children with US-born parents), respectively. After adjusting for age, gender, ethnicity, socioeconomic status, perceived neighborhood safety, television viewing, computer use, and physical activity, first-generation immigrant children, overall, had 26% lower odds of obesity than native-born children. Obesity and overweight prevalence was lower for immigrant black and white children than their native-born counterparts, while obesity and overweight prevalence among Hispanic children did not vary significantly by generational status. Compared with native-born white children, the adjusted odds of obesity were 64% higher for native-born blacks, 55% higher for second-generation Hispanic immigrants, and 63% lower for first-generation Asian immigrants. Adjusted immigrant differentials in overweight risks were also marked. Socioeconomic, demographic, and behavioral factors accounted for 61 and 35% of ethnic-immigrant disparities in obesity and overweight prevalence, respectively. Immigrant patterns in childhood obesity and overweight vary substantially by ethnicity and generational status. To reduce disparities, obesity prevention programs must target at-risk children of both immigrant and US-born parents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - obesity
KW - overweight
KW - prevalence
KW - ethnicity
KW - racism
KW - 2009
KW - Obesity
KW - Overweight
KW - Epidemiology
KW - Ethnic Identity
KW - Racism
KW - 2009
DO - 10.1007/s10900-009-9148-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08724-010&site=ehost-live&scope=site
UR - gsingh@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-10898-006
AN - 2009-10898-006
AU - Stephenson, Michael T.
AU - Quick, Brian L.
AU - Witte, Kim
AU - Vaught, Charles
AU - Booth-Butterfield, Steve
AU - Patel, Dhaval
T1 - Conversations among coal miners in a campaign to promote hearing protection.
JF - Journal of Applied Communication Research
JO - Journal of Applied Communication Research
JA - J Appl Commun Res
Y1 - 2009/08//
VL - 37
IS - 3
SP - 317
EP - 337
CY - United Kingdom
PB - Taylor & Francis
SN - 0090-9882
SN - 1479-5752
AD - Stephenson, Michael T., Department of Communication, Texas A&M, 4234 TAMU, College Station, TX, US, 77843-4234
N1 - Accession Number: 2009-10898-006. Partial author list: First Author & Affiliation: Stephenson, Michael T.; Department of Communication, Texas A&M University, College Station, TX, US. Release Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Auditory Acuity; Business Organizations; Conversation; Messages; Safety Devices. Minor Descriptor: Health Promotion; Incentives. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 21. Issue Publication Date: Aug, 2009. Copyright Statement: National Communication Association. 2009.
AB - Although working in a coal mine can diminish one’s hearing capabilities by 50%, not until 2000 did federal laws require companies to establish noise standards in order to help prevent hearing loss among their employees. Since then, researchers have worked with safety administrators to develop effective messages promoting hearing protection and testing. This research assessed the effects of campaign messages on discussing campaign postcards and talking with others about a helmet-sticker incentive. The results, which are discussed with a focus on future campaigns, indicate that hearing-related attitudes, intentions, and behaviors are the most influenced by messages that were affectively neutral and least influenced by messages that were affectively negative. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - conversations
KW - coal miners
KW - campaign messages
KW - hearing protection
KW - campaign postcards
KW - helmet sticker incentive
KW - health promotion
KW - 2009
KW - Auditory Acuity
KW - Business Organizations
KW - Conversation
KW - Messages
KW - Safety Devices
KW - Health Promotion
KW - Incentives
KW - 2009
U1 - Sponsor: Centers for Disease Control and Prevention, National Institute of Occupational Safety and Health. Grant: BH61-8533. Recipients: No recipient indicated
DO - 10.1080/00909880903025895
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-10898-006&site=ehost-live&scope=site
UR - mstephenson@tamu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18327-006
AN - 2009-18327-006
AU - Hsiao, Hongwei
AU - Whitestone, Jennifer
AU - Taylor, Stacie
AU - Godby, Mary
AU - Guan, Jinhua
T1 - Harness sizing and strap length configurations.
JF - Human Factors
JO - Human Factors
JA - Hum Factors
Y1 - 2009/08//
VL - 51
IS - 4
SP - 497
EP - 518
CY - US
PB - Sage Publications
SN - 0018-7208
SN - 1547-8181
AD - Hsiao, Hongwei, Protective Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV, US, 26505
N1 - Accession Number: 2009-18327-006. PMID: 19899360 Partial author list: First Author & Affiliation: Hsiao, Hongwei; National Institute for Occupational Safety and Health, Morgantown, WV, US. Other Publishers: Human Factors & Ergonomics Society. Release Date: 20100104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Business and Industrial Personnel; Costs and Cost Analysis; Human Factors Engineering; Occupational Safety; Size. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 22. Issue Publication Date: Aug, 2009. Publication History: Accepted Date: Jul 13, 2009; First Submitted Date: Mar 26, 2009. Copyright Statement: Human Factors and Ergonomics Society. 2009.
AB - Objective: This article describes the derivation of strap lengths and adjustments to fall-arrest harnesses and the development of harness size configurations. Background: Updated harness sizing configurations are needed to accommodate diverse populations in the current workforce. Method: Three-dimensional torso anthropometric data from 243 women and 258 men were incorporated into eight validated equations to develop a cost-effective harness sizing plan and to define strap lengths. Results: To met strap adjustable range goals and to accommodate 95% to 98% of the estimated population, two sizing options were identified. Conclusion: Study outcomes suggest system improvement with three to four sizes for women and three to four sizes for men, on which the adjustment ranges of the torso straps were within 15 to 17 cm and within 20 to 23 cm on thigh and hip straps. Application: This research provided harness sizing and cut-length information for harness design to reduce the risk of worker injury that results from poor fit or improper size selection. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - harness sizing
KW - strap length configurations
KW - cost effective harness sizing plans
KW - 2009
KW - Business and Industrial Personnel
KW - Costs and Cost Analysis
KW - Human Factors Engineering
KW - Occupational Safety
KW - Size
KW - 2009
DO - 10.1177/0018720809346320
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18327-006&site=ehost-live&scope=site
UR - hhsiao@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11857-007
AN - 2009-11857-007
AU - Weidmer-Ocampo, Beverly
AU - Johansson, Patrick
AU - Dalpoas, Debbie
AU - Wharton, David
AU - Darby, Charles
AU - Hays, Ron D.
T1 - Adapting CAHPS® for an American Indian population.
JF - Journal of Health Care for the Poor and Underserved
JO - Journal of Health Care for the Poor and Underserved
JA - J Health Care Poor Underserved
Y1 - 2009/08//
VL - 20
IS - 3
SP - 695
EP - 712
CY - US
PB - Johns Hopkins University Press
SN - 1049-2089
SN - 1548-6869
AD - Weidmer-Ocampo, Beverly, RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, CA, US, 90407-2138
N1 - Accession Number: 2009-11857-007. PMID: 19648698 Partial author list: First Author & Affiliation: Weidmer-Ocampo, Beverly; RAND Corporation, Santa Monica, CA, US. Release Date: 20100104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: American Indians; Consumer Behavior; Health Care Services; Hospital Programs; Measurement. Minor Descriptor: Clinics; Experiences (Events); Patients; Quality of Care; Systems; Health Personnel. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Tests & Measures: Getting Care Quickly; Getting Needed Care; Communication with Providers; Shared Decision Making; Courtesy/Respect and Helpfulness of Clerks and Receptionists; Health Education; Perceived Discrimination. Methodology: Empirical Study; Quantitative Study. Page Count: 18. Issue Publication Date: Aug, 2009.
AB - Objective: Develop a culturally appropriate, reliable, and valid survey that can be used by the Choctaw Nation Health Services (CNHS) to compare patients' health care experiences across CNHS clinics, and to support quality improvement efforts. Methods: We worked with CNHS staff to adapt the CAHPS Clinician and Group Survey for this purpose. We conducted cognitive interviews and a field-test to evaluate the survey. Results: Cognitive testing yielded a survey that covered issues relevant to CNHS patients. Field testing yielded 696 surveys, (58% response rate). Analyses provided support for internal consistency of multi-item scales. Correlations among scales indicate the scales were related to one another but not redundant. Discussion: The CAHPS American Indian Survey is useful for assessing perceptions of care at the clinic level and across different clinics. The close partnership with CNHS helped yield a survey that is scientifically sound, reflects how services are organized and delivered locally, and meets CNHS information needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Consumer Assessment of Healthcare Providers and Systems programs
KW - American Indian population
KW - Choctaw Nation Health Services
KW - patients' health care experiences
KW - clinics
KW - quality improvement efforts
KW - 2009
KW - American Indians
KW - Consumer Behavior
KW - Health Care Services
KW - Hospital Programs
KW - Measurement
KW - Clinics
KW - Experiences (Events)
KW - Patients
KW - Quality of Care
KW - Systems
KW - Health Personnel
KW - 2009
U1 - Sponsor: Agency for Healthcare Research and Quality/ Center for Medicare and Medicaid Services. Grant: U18 HS09204; U18 HS016980. Other Details: Cooperative agreements. Recipients: No recipient indicated
DO - 10.1353/hpu.0.0166
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11857-007&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-06500-006
AN - 2011-06500-006
AU - Smith, E. N.
AU - Bloss, C. S.
AU - Badner, J. A.
AU - Barrett, T.
AU - Belmonte, P. L.
AU - Berrettini, W.
AU - Byerley, W.
AU - Coryell, W.
AU - Craig, D.
AU - Edenberg, H. J.
AU - Eskin, E.
AU - Foroud, T.
AU - Gershon, E.
AU - Greenwood, T. A.
AU - Hipolito, M.
AU - Koller, D. L.
AU - Lawson, W. B.
AU - Liu, C.
AU - Lohoff, F.
AU - McInnis, M. G.
AU - McMahon, F. J.
AU - Mirel, D. B.
AU - Murray, S. S.
AU - Nievergelt, C.
AU - Nurnberger, J.
AU - Nwulia, E. A.
AU - Paschall, J.
AU - Potash, J. B.
AU - Rice, J.
AU - Schulze, T. G.
AU - Scheftner, W.
AU - Panganiban, C.
AU - Zaitlen, N.
AU - Zandi, P. P.
AU - Zöllner, S.
AU - Schork, N. J.
AU - Kelsoe, J. R.
T1 - Genome-wide association study of bipolar disorder in European American and African American individuals.
JF - Molecular Psychiatry
JO - Molecular Psychiatry
JA - Mol Psychiatry
Y1 - 2009/08//
VL - 14
IS - 8
SP - 755
EP - 763
CY - United Kingdom
PB - Nature Publishing Group
SN - 1359-4184
SN - 1476-5578
AD - Schork, N. J., Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Avenue, MEM 275, La Jolla, CA, US, 92037
N1 - Accession Number: 2011-06500-006. PMID: 19488044 Partial author list: First Author & Affiliation: Smith, E. N.; Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, US. Release Date: 20111003. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Kelsoe, J. R. Major Descriptor: Bipolar Disorder; Genetics; Genome; Racial and Ethnic Differences. Minor Descriptor: Blacks; Whites. Classification: Affective Disorders (3211). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. Supplemental Data: Tables and Figures Internet. References Available: Y. Page Count: 9. Issue Publication Date: Aug, 2009. Publication History: First Posted Date: Jun 2, 2009; Accepted Date: Apr 13, 2009; Revised Date: Apr 3, 2009; First Submitted Date: Jan 6, 2009. Copyright Statement: All rights reserved. Nature Publishing Group. 2009.
AB - To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n = 1001 cases; n = 1033 controls), and one involving a sample of individuals of African ancestry (AA; n = 345 cases; n = 670 controls). For the EA sample, single-nucleotide polymorphisms (SNPs) with the strongest statistical evidence for association included rs5907577 in an intergenic region at Xq27.1 (P = 1.6 × 10-6) and rs10193871 in NAP5 at 2q21.2 (P = 9.8 × 10-6). For the AA sample, SNPs with the strongest statistical evidence for association included rs2111504 in DPY19L3 at 19q13.11 (P = 1.5 × 10-6) and rs2769605 in NTRK2 at 9q21.33 (P = 4.5 × 10-5). We also investigated whether we could provide support for three regions previously associated with BD, and we showed that the ANK3 region replicates in our sample, along with some support for C15Orf53; other evidence implicates BD candidate genes such as SLITRK2. We also tested the hypothesis that BD susceptibility variants exhibit genetic background-dependent effects. SNPs with the strongest statistical evidence for genetic background effects included rs11208285 in ROR1 at 1p31.3 (P = 1.4 × 10-6), rs4657247 in RGS5 at 1q23.3 (P = 4.1 × 10-6), and rs7078071 in BTBD16 at 10q26.13 (P = 4.5 × 10-6). This study is the first to conduct GWA of BD in individuals of AA and suggests that genetic variations that contribute to BD may vary as a function of ancestry. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - genome
KW - genetics
KW - bipolar disorder
KW - European Americans
KW - African Americans
KW - 2009
KW - Bipolar Disorder
KW - Genetics
KW - Genome
KW - Racial and Ethnic Differences
KW - Blacks
KW - Whites
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Recipients: No recipient indicated
U1 - Sponsor: National Human Genome Research Institute. Grant: MH078151; MH081804; MH059567. Recipients: Kelsoe, J. R.
U1 - Sponsor: Genetic Association Information Network (GAIN). Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: McMahon, F. J.; Schulze, T. G.
U1 - Sponsor: Tzedakah Foundation. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: R01 MH59553. Recipients: No recipient indicated
U1 - Sponsor: Philip and Marcia Cohen. Recipients: No recipient indicated
U1 - Sponsor: American Philosophical Society, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: K08 MH080372. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, National Library of Medicine, Intramural Research Program, US. Recipients: No recipient indicated
U1 - Sponsor: National Institutes of Health, US. Grant: 1U54RR025204-01. Recipients: No recipient indicated
DO - 10.1038/mp.2009.43
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-06500-006&site=ehost-live&scope=site
UR - ORCID: 0000-0001-5766-8923
UR - ORCID: 0000-0002-9469-305X
UR - ORCID: 0000-0002-9324-7090
UR - ORCID: 0000-0002-6080-6503
UR -
UR - nschork@scripps.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11362-001
AN - 2009-11362-001
AU - Weaver, France
AU - Stearns, Sally C.
AU - Norton, Edward C.
AU - Spector, William
T1 - Proximity to death and participation in the long-term care market.
JF - Health Economics
JO - Health Economics
JA - Health Econ
Y1 - 2009/08//
VL - 18
IS - 8
SP - 867
EP - 883
CY - US
PB - John Wiley & Sons
SN - 1057-9230
SN - 1099-1050
AD - Weaver, France, Swiss Health Observatory, Espace de l'Europe 10, 2010, Neuchatel, Switzerland
N1 - Accession Number: 2009-11362-001. PMID: 18770873 Partial author list: First Author & Affiliation: Weaver, France; Swiss Health Observatory, Neuchatel, Switzerland. Release Date: 20091221. Correction Date: 20130114. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Death Attitudes; Home Care; Life Expectancy; Long Term Care; Nursing Homes. Minor Descriptor: Participation. Classification: Health & Mental Health Services (3370); Developmental Psychology (2800). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 17. Issue Publication Date: Aug, 2009. Publication History: First Posted Date: Sep 4, 2008; Accepted Date: Jul 11, 2008; Revised Date: May 7, 2008; First Submitted Date: Nov 3, 2006. Copyright Statement: John Wiley & Sons, Ltd. 2008.
AB - The extent to which increasing longevity increases per capita demand for long-term care depends on the degree to which utilization is concentrated at the end of life. We estimate the marginal effect of proximity to death, measured by being within 2 years of death, on the probabilities of nursing home and formal home care use, and we determine whether this effect differs by availability of informal care — i.e. marital status and co-residence with an adult child. The analysis uses a sample of elderly aged 70+from the 1993-2002 Health and Retirement Study. Simultaneous probit models address the joint decisions to use long-term care and co-reside with an adult child. Overall, proximity to death significantly increases the probability of nursing home use by 50.0% and of formal home care use by 12.4%. Availability of informal support significantly reduces the effect of proximity to death. Among married elderly, proximity to death has no effect on institutionalization. In conclusion, proximity to death is one of the main drivers of long-term care use, but changes in sources of informal support, such as an increase in the proportion of married elderly, may lessen its importance in shaping the demand for long-term care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - death proximity
KW - participation
KW - long-term care markets
KW - nursing home usage
KW - formal home care usage
KW - 2009
KW - Death Attitudes
KW - Home Care
KW - Life Expectancy
KW - Long Term Care
KW - Nursing Homes
KW - Participation
KW - 2009
U1 - Sponsor: Swiss Science Foundation, Switzerland. Grant: PBSK1-106659. Recipients: No recipient indicated
U1 - Sponsor: National Institute on Aging, US. Grant: P30 AG024376. Other Details: Demography and Economics of Aging Research Group at The University of North Carolina at Chapel Hill. Recipients: No recipient indicated
DO - 10.1002/hec.1409
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11362-001&site=ehost-live&scope=site
UR - france.weaver@bfs.admin.ch
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11985-013
AN - 2009-11985-013
AU - Murrie, Daniel C.
AU - Henderson, Craig E.
AU - Vincent, Gina M.
AU - Rockett, Jennifer L.
AU - Mundt, Cynthia
T1 - Psychiatric symptoms among juveniles incarcerated in adult prison.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/08//
VL - 60
IS - 8
SP - 1092
EP - 1097
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Murrie, Daniel C., Institute of Law, Psychiatry, and Public Policy, University of Virginia School of Medicine, P.O. Box 800660, Charlottesville, VA, US, 22908-0660
N1 - Accession Number: 2009-11985-013. PMID: 19648197 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Murrie, Daniel C.; Institute of Law, Psychiatry and Public Policy, University of Virginia School of Medicine, Charlottesville, VA, US. Release Date: 20091005. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Crime; Health Service Needs; Incarceration; Juvenile Delinquency; Prisons. Minor Descriptor: Health Screening; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adolescence (13-17 yrs) (200). Tests & Measures: Massachusetts Youth Screening Instrument– Version 2. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Aug, 2009.
AB - Objective: Although studies reveal substantial mental health treatment needs among youths in the juvenile justice system, far less is known about young offenders transferred to adult criminal court. This statewide study examined the mental health needs of young offenders who committed serious crimes and were transferred to adult court and subsequently incarcerated in a prison for adults. Methods: Sixty-four boys aged 16 and 17 years who were incarcerated in the Texas adult correctional system completed the Massachusetts Youth Screening Instrument–Version 2 (MAYSI-2), a mental health screening measure widely used in the juvenile justice system. Scores from the youths in adult prison were compared with those of a matched sample of youths in juvenile correctional facilities, drawn from the MAYSI-2 normative data. Results: Youths in adult prison reported substantial symptoms of mental health problems. Most youths surveyed (51%) scored above the highest clinical cutoff (the 'warning' range) on at least one MAYSI-2 subscale. For every clinical subscale except suicide ideation, the majority of youths (54% to 70%, depending on the subscale) scored above the 'caution' range. Juveniles in adult prison reported higher rates of symptoms than did those in juvenile correctional facilities (effect sizes ranged from d = .18 to d = .65, depending on the subscale). Conclusions: Although the mental health needs of youths in the juvenile justice system are well documented, this study reveals that mental health treatment needs appear to be even more pronounced in the small subgroup of youths transferred to the adult criminal justice system and incarcerated in adult prison. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychiatric symptoms
KW - juveniles
KW - incarceration
KW - adult prison
KW - mental health needs
KW - criminal court
KW - juvenile justice system
KW - serious crimes
KW - 2009
KW - Crime
KW - Health Service Needs
KW - Incarceration
KW - Juvenile Delinquency
KW - Prisons
KW - Health Screening
KW - Mental Health
KW - 2009
U1 - Sponsor: William T. Grant Foundation. Grant: 2281. Other Details: For the National Norms for the MAYSI-2 Study. Recipients: No recipient indicated
DO - 10.1176/appi.ps.60.8.1092
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11985-013&site=ehost-live&scope=site
UR - murrie@virginia.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Gendel, Steven M.
T1 - Allergen databases and allergen semantics
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2009/08/02/Aug2009 Supplement
VL - 54
IS - 3
M3 - Article
SP - S7
EP - S10
SN - 02732300
AB - Abstract: The efficacy of any specific bioinformatic analysis of the potential allergenicity of new food proteins depends directly on the nature and content of the databases that are used in the analysis. A number of different allergen-related databases have been developed, each designed to meet a different need. These databases differ in content, organization, and accessibility. These differences create barriers for users and prevent data sharing and integration. The development and application of appropriate semantic web technologies, (for example, a food allergen ontology) could help to overcome these barriers and promote the development of more advanced analytic capabilities. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food allergy
KW - Allergens
KW - Food -- Safety measures
KW - Proteins
KW - Bioinformatics
KW - Computers in biology
KW - Allergen sequences
KW - Database
KW - Food safety
KW - Informatics
KW - Semantic web
N1 - Accession Number: 43341604; Gendel, Steven M. 1; Email Address: steven.gendel@fda.hhs.gov; Affiliations: 1: Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, United States; Issue Info: Aug2009 Supplement, Vol. 54 Issue 3, pS7; Thesaurus Term: Food allergy; Thesaurus Term: Allergens; Thesaurus Term: Food -- Safety measures; Subject Term: Proteins; Subject Term: Bioinformatics; Subject Term: Computers in biology; Author-Supplied Keyword: Allergen sequences; Author-Supplied Keyword: Database; Author-Supplied Keyword: Food safety; Author-Supplied Keyword: Informatics; Author-Supplied Keyword: Semantic web; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.yrtph.2008.10.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43341604&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cutler, Jennifer
AU - Schleihauf, Emily
AU - Hatchette, Todd F.
AU - Billard, Bev
AU - Watson-Creed, Gaynor
AU - Davidson, Ross
AU - Yan Li
AU - Bastien, Nathalie
AU - Sarwal, Shelly
T1 - Investigation of the first cases of human-to-human infection with the new swine-origin influenza A (H1N1) virus in Canada.
JO - CMAJ: Canadian Medical Association Journal
JF - CMAJ: Canadian Medical Association Journal
Y1 - 2009/08/04/
VL - 181
IS - 3/4
M3 - Article
SP - 159
EP - 163
SN - 08203946
AB - The outbreak of human infection due to the novel swine-origin influenza A (H1N1) virus began in Mexico in March 2009. As of July 6, 2009, more than 94 000 laboratory-confirmed cases were reported in over 100 countries, including 7983 cases in Canada. In this report, we describe the epidemiologic and clinical characteristics of the first cluster of reported cases of human-to-human transmission of the new influenza virus in Canada. [ABSTRACT FROM AUTHOR]
AB - Copyright of CMAJ: Canadian Medical Association Journal is the property of Joule Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFECTION
KW - MEDICAL microbiology
KW - H1N1 (2009) influenza
KW - CLINICAL trials
KW - MEXICO
KW - CANADA
N1 - Accession Number: 43396110; Cutler, Jennifer 1,2 Schleihauf, Emily 2,3 Hatchette, Todd F. 4,5 Billard, Bev 2 Watson-Creed, Gaynor 2,6 Davidson, Ross 4,5,7 Yan Li 8 Bastien, Nathalie 8 Sarwal, Shelly 2,6; Email Address: shelly.sarwal@gov.ns.ca; Affiliation: 1: From the Canadian Field Epidemiology Program, Public Health Agency of Canada, Ottawa, Ont. 2: Nova Scotia Department of Health Promotion and Protection, Halifax, NS 3: Canadian Public Health Service, Public Health Agency of Canada, Ottawa, Ont. 4: Division of Microbiology, Department of Pathology and Laboratory Medicine, Capital District Health Authority, Halifax, NS 5: Department of Pathology, Dalhousie University, Halifax, NS 6: Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS 7: Department of Microbiology and Immunology, Dalhousie University, Halifax, NS 8: National Microbiology Laboratory, Public Health Agency of Canada, Ottawa, Ont.; Source Info: 8/4/2009, Vol. 181 Issue 3/4, p159; Subject Term: INFECTION; Subject Term: MEDICAL microbiology; Subject Term: H1N1 (2009) influenza; Subject Term: CLINICAL trials; Subject Term: MEXICO; Subject Term: CANADA; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1503/cmaj.090859
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43396110&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - El Sahly, H.M.
AU - Atmar, R.L.
AU - Patel, S.M.
AU - Wells, J.M.
AU - Cate, T.
AU - Ho, M.
AU - Guo, K.
AU - Pasetti, M.F.
AU - Lewis, D.E.
AU - Sztein, M.B.
AU - Keitel, W.A.
T1 - Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humans
JO - Vaccine
JF - Vaccine
Y1 - 2009/08/06/
VL - 27
IS - 36
M3 - Article
SP - 4905
EP - 4911
SN - 0264410X
AB - Abstract: We evaluated the safety, reactogenicity and immunogenicity of escalating doses of a new Francisella tularensis Live Vaccine Strain (LVS) lot by scarification (SCAR) or subcutaneously (SQ) in humans. Subjects (N =10/group) received one dose of LVS via SCAR at 105,107 or 109 cfu/ml or SQ at 102, 103,104 or 105 cfu/ml; 14 subjects received placebo. All doses/routes were well tolerated. When compared to placebo, vaccination with 107 SCAR and 109 SCAR resulted in significantly higher serologic response frequencies, as measured by ELISA for IgG, IgM, IgA and microagglutination; whereas vaccination with 105 SCAR, 107 SCAR 109 SCAR and 105 SQ elicited a significantly higher interferon-γ response frequency. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Agglutination
KW - Francisella tularensis
KW - Drugs -- Safety measures
KW - Immunogenetics
KW - Bacterial vaccines
KW - Tularemia
KW - Dosage of drugs
KW - Placebos (Medicine)
KW - Clinical trials
KW - Clinical trial
KW - Live vaccine strain
KW - Safety and immunogenicity
KW - Tularemia vaccine
N1 - Accession Number: 43413256; El Sahly, H.M. 1,2; Email Address: hanae@bcm.edu; Atmar, R.L. 1,2; Patel, S.M. 1,2; Wells, J.M. 1; Cate, T. 1,2; Ho, M. 3; Guo, K. 4; Pasetti, M.F. 5; Lewis, D.E. 6; Sztein, M.B. 5; Keitel, W.A. 1,2; Affiliations: 1: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States; 2: Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX, United States; 3: Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD, United States; 4: EMMES Corporation, Rockville, MD, United States; 5: Center for Vaccine Development, Department of Pediatrics, University of Maryland, Baltimore, MD, United States; 6: Department of Immunology, Baylor College of Medicine, Houston, TX, United States; Issue Info: Aug2009, Vol. 27 Issue 36, p4905; Thesaurus Term: VACCINATION; Thesaurus Term: Agglutination; Subject Term: Francisella tularensis; Subject Term: Drugs -- Safety measures; Subject Term: Immunogenetics; Subject Term: Bacterial vaccines; Subject Term: Tularemia; Subject Term: Dosage of drugs; Subject Term: Placebos (Medicine); Subject Term: Clinical trials; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: Live vaccine strain; Author-Supplied Keyword: Safety and immunogenicity; Author-Supplied Keyword: Tularemia vaccine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.06.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43413256&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cho, Yong Kyun
AU - Yun, Jung Won
AU - Park, Jung Ho
AU - Kim, Hong Joo
AU - Park, Dong Il
AU - Sohn, Chong Il
AU - Jeon, Woo Kyu
AU - Kim, Byung Ik
AU - Jin, Wook
AU - Kwon, Yong-Hyun
AU - Shin, Mi-Kyung
AU - Yoo, Tae Moo
AU - Kang, Ju-Hee
AU - Park, Chang-Shin
T1 - Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers
JO - Life Sciences
JF - Life Sciences
Y1 - 2009/08/12/
VL - 85
IS - 7/8
M3 - Article
SP - 281
EP - 290
SN - 00243205
AB - Abstract: Aims: Defects in intrahepatic nitric oxide (NO) are attributed to reduced blood flow due to portal hypertension caused by diminished endothelial NO synthase (eNOS) activity. The aim of this study is to identify the therapeutic effects of silymarin on eNOS/NO-related enzymes and hepatic enzymes in carbon tetrachloride (CCl4)-induced cirrhotic rats. Main methods: CCl4 treated for 12 weeks was discontinued and then administrated with silymarin daily for 4 weeks. Collagen concentrations were determined by measuring hydroxyproline content. Serum was assayed for hepatic enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities. NOS activities were measured by oxyhemoglobin oxidation assay, and levels of enzyme expression and phosphorylation were detected by Western-blot analyses. Key findings: Silymarin treatment restored the values for collagen content and ALT and ALP activities when compared to the values with spontaneous resolution following discontinuation of CCl4. CCl4 treatment highly increased eNOS expression and NOS activity in livers, but the phosphorylation was markedly decreased. Silymarin decreased significantly eNOS expression and activity. Expression and/or phosphorylation of enzymes activating eNOS were unchanged (Akt and AMPK) or decreased (PKA) by silymarin. Especially, the expression of caveolin-1, an inhibitor of eNOS was unchanged by CCl4, but its phosphorylation was significantly increased. However, silymarin markedly increased caveolin-1 expression but decreased its phosphorylation to expression. Significance: These results suggest that chronic silymarin treatment can improve cirrhosis-induced liver enzyme activities and fibrosis, but may aggravate the hemodynamic eNOS activity, particularly by decreasing eNOS expression and increasing caveolin-1 expression. [Copyright &y& Elsevier]
AB - Copyright of Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLAVONOIDS
KW - HEPATOTOXICOLOGY
KW - PREVENTION
KW - GENE expression
KW - NITRIC-oxide synthases
KW - LIVER diseases -- Treatment
KW - CARBON tetrachloride
KW - ENDOTHELIUM
KW - RATS as laboratory animals
KW - THERAPEUTIC use
KW - Carbon tetrachloride
KW - Caveolin-1
KW - Endothelial nitric oxide synthase
KW - Liver cirrhosis
KW - Silymarin
N1 - Accession Number: 43529556; Cho, Yong Kyun 1 Yun, Jung Won 1 Park, Jung Ho 1 Kim, Hong Joo 1 Park, Dong Il 1 Sohn, Chong Il 1 Jeon, Woo Kyu 1 Kim, Byung Ik 1 Jin, Wook 2 Kwon, Yong-Hyun 3 Shin, Mi-Kyung 3 Yoo, Tae Moo 4 Kang, Ju-Hee 3 Park, Chang-Shin 3; Email Address: parkshin@inha.ac.kr; Affiliation: 1: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Republic of Korea 2: Laboratory of Molecular Disease and Cell Regulation Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon 406-840, Republic of Korea 3: Department of Pharmacology, Center for Advanced Medical Education, Inha University College of Medicine by BK-21 Project, MTRC, Inha Research Institute for Medical Science, Inha University, Incheon 400-712, Republic of Korea 4: Division of Risk Assessment, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; Source Info: Aug2009, Vol. 85 Issue 7/8, p281; Subject Term: FLAVONOIDS; Subject Term: HEPATOTOXICOLOGY; Subject Term: PREVENTION; Subject Term: GENE expression; Subject Term: NITRIC-oxide synthases; Subject Term: LIVER diseases -- Treatment; Subject Term: CARBON tetrachloride; Subject Term: ENDOTHELIUM; Subject Term: RATS as laboratory animals; Subject Term: THERAPEUTIC use; Author-Supplied Keyword: Carbon tetrachloride; Author-Supplied Keyword: Caveolin-1; Author-Supplied Keyword: Endothelial nitric oxide synthase; Author-Supplied Keyword: Liver cirrhosis; Author-Supplied Keyword: Silymarin; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.lfs.2009.06.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43529556&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Day, J. B.
AU - Basavanna, U.
AU - Sharma, S. K.
T1 - Development of a Cell Culture Method To Isolate and Enrich Salmonella enterica Serotype Enteritidis from Shell Eggs for Subsequent Detection by Real-Time PCR.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/08/15/
VL - 75
IS - 16
M3 - Article
SP - 5321
EP - 5327
SN - 00992240
AB - Salmonella enterica serotype Enteritidis is a major cause of nontyphoidal salmonellosis from ingestion of contaminated raw or undercooked shell eggs. Current techniques used to identity Salmonella serotype Enteritidis in eggs are extremely laborious and time-consuming. In this study, a novel eukaryotic cell culture system was combined with real-time PCR analysis to rapidly identify Salmonella serotype Enteritidis in raw shell eggs. The system was compared to the standard microbiological method of the International Organization for Standardization (Anonymous, Microbiology of food and animal feeding stuffs—horizontal method for the detection of Salmonella, 2002). The novel technique utilizes a mouse macrophage cell line (RAW 264.7) as the host for the isolation and intracellular replication of Salmonella serotype Enteritidis. Exposure of macrophages to Salmonella serotype Enteritidis-contaminated eggs results in uptake and intracellular replication of the bacterium, which can subsequently be detected by real-time PCR analysis of the DNA released after disruption of infected macrophages. Macrophage monolayers were exposed to eggs contaminated with various quantities of Salmonella serotype Enteritidis. As few as 10 CFU/ml was detected in cell lysates from infected macrophages after 10 h by real-time PCR using primer and probe sets specific for DNA segments located on the Salmonella serotype Enteritidis genes sefA and orgC. Salmonella serotype Enteritidis could also be distinguished from other non-serogroup D Salmonella serotypes by using the sefAand orgC-specific primer and probe sets. Confirmatory identification of Salmonella serotype Enteritidis in eggs was also achieved by isolation of intracellular bacteria from lysates of infected macrophages on xylose lysine deoxycholate medium. This method identifies Salmonella serotype Enteritidis from eggs in less than 10 h compared to the more than 5 days required for the standard reference microbiological method of the International Organization for Standardization (Microbiology of food and animal feeding stuffs—horizontal method for the detection of Salmonella, 2002). [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL culture
KW - SALMONELLA enteritidis
KW - SEROTYPES
KW - FOODBORNE diseases
KW - EUKARYOTIC cells
KW - MICROBIOLOGY
KW - DNA
KW - MACROPHAGES
KW - INTRACELLULAR pathogens
N1 - Accession Number: 44046993; Day, J. B. 1; Email Address: james.day@fda.hhs.gov Basavanna, U. 1 Sharma, S. K. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Matyland 20740; Source Info: Aug2009, Vol. 75 Issue 16, p5321; Subject Term: CELL culture; Subject Term: SALMONELLA enteritidis; Subject Term: SEROTYPES; Subject Term: FOODBORNE diseases; Subject Term: EUKARYOTIC cells; Subject Term: MICROBIOLOGY; Subject Term: DNA; Subject Term: MACROPHAGES; Subject Term: INTRACELLULAR pathogens; Number of Pages: 7p; Document Type: Article
L3 - 10.1128/AEM.02422-08
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Elinos-Calderón, Diana
AU - Robledo-Arratia, Yolanda
AU - Pérez-De La Cruz, Verónica
AU - Pedraza-Chaverrí, José
AU - Ali, Syed
AU - Santamaría, Abel
T1 - Early nerve ending rescue from oxidative damage and energy failure by l-carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities.
JO - Experimental Brain Research
JF - Experimental Brain Research
Y1 - 2009/08/15/
VL - 197
IS - 3
M3 - Article
SP - 287
EP - 296
SN - 00144819
AB - Cell rescue is a primary need during acute and chronic insults to the central nervous system. Functional preservation during the early stages of toxicity in a given degenerative event may represent a significant amelioration of detrimental processes linked to neuronal cell loss. Excitotoxicity and depleted cellular energy are toxic events leading to cell death in several neurodegenerative disorders. In this work, the effects of the well-known antioxidant and energy precursor, l-carnitine ( l-CAR), were tested as a post-treatment in two neurotoxic models under in vitro and in vivo conditions. The experimental models tested included: (1) a typical excitotoxic and pro-oxidant inducer, quinolinic acid (QUIN); and (2) a mitochondrial energy inhibitor, 3-nitropropionic acid (3-NP). For in vitro studies, increasing concentrations of l-CAR (10–1,000 μM) were added to the isolated brain synaptosomes at different times (1, 3 and 6 h) after the incubation with toxins (100 μM QUIN and 1 mM 3-NP), and 30 min later, lipid peroxidation (LP) and mitochondrial dysfunction (MD) were evaluated. For in vivo purposes, l-CAR (100 mg/kg, i.p.) was given to rats either as a single administration 120 min after the intrastriatal infusion of QUIN (240 nmol/μl) or 3-NP (500 nmol/μl), or for 7 consecutive days (starting 120 min post-lesion). LP and MD were evaluated 4 h and 7 days post-lesions in isolated striatal synaptosomes. Our results show that, despite some variations depending on the toxic model tested, the time of exposure, or the biomarker evaluated, nerve ending protection can be mostly achieved by l-CAR within the first hours after the toxic insults started, suggesting that targeting the ongoing oxidative damage and/or energy depletion during the first stages of neurotoxic events is essential to rescue nerve endings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Brain Research is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL research
KW - NERVOUS system
KW - QUINOLINIC acid
KW - NEURONAL ceroid-lipofuscinosis
KW - NEUROTOXICOLOGY
KW - MITOCHONDRIAL DNA
KW - Energy depletion
KW - Excitotoxicity
KW - Functional recovery
KW - L-carnitine post-treatment
KW - Oxidative damage
KW - Synaptosomal fractions
N1 - Accession Number: 43520234; Elinos-Calderón, Diana 1 Robledo-Arratia, Yolanda 1 Pérez-De La Cruz, Verónica 1 Pedraza-Chaverrí, José 2 Ali, Syed 3 Santamaría, Abel 1,3; Email Address: absada@yahoo.com; Affiliation: 1: Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur 3877, C.P 14269 Mexico D.F., Mexico 2: Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, 04510 Mexico D.F., Mexico 3: Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Aug2009, Vol. 197 Issue 3, p287; Subject Term: MEDICAL research; Subject Term: NERVOUS system; Subject Term: QUINOLINIC acid; Subject Term: NEURONAL ceroid-lipofuscinosis; Subject Term: NEUROTOXICOLOGY; Subject Term: MITOCHONDRIAL DNA; Author-Supplied Keyword: Energy depletion; Author-Supplied Keyword: Excitotoxicity; Author-Supplied Keyword: Functional recovery; Author-Supplied Keyword: L-carnitine post-treatment; Author-Supplied Keyword: Oxidative damage; Author-Supplied Keyword: Synaptosomal fractions; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1007/s00221-009-1913-3
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jung, Carina M.
AU - Heinze, Thomas M.
AU - Schnackenberg, Laura K.
AU - Mullis, Lisa B.
AU - Elkins, Stephanie A.
AU - Elkins, Christopher A.
AU - Steele, Roger S.
AU - Sutherland, John B.
T1 - Interaction of dietary resveratrol with animal-associated bacteria.
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
Y1 - 2009/08/15/
VL - 297
IS - 2
M3 - Article
SP - 266
EP - 273
PB - Oxford University Press / USA
SN - 03781097
AB - Resveratrol (3,5,4′-trihydroxy- trans-stilbene), an antifungal phytoalexin produced by grapes, peanuts, and Japanese knotweeds, is thought to be a beneficial dietary phytochemical in red wine and grape juice. Information on its antibacterial properties and biotransformation, however, is limited. We surveyed the interactions of resveratrol with 43 strains of bacterial species that are often animal- or human-associated. Resveratrol at 50 mg L−1 reduced the growth rates of most of the bacteria tested, but did not totally prevent growth even at much higher levels. Eleven of the 43 bacteria were capable of transforming at least 20% of the resveratrol. Three major metabolites were identified as resveratroloside, piceid, and dihydroresveratrol, and three other metabolites were partially characterized. [ABSTRACT FROM AUTHOR]
AB - Copyright of FEMS Microbiology Letters is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Bacteria
KW - Antifungal agents
KW - Biotransformation (Metabolism)
KW - Antibacterial agents
KW - Metabolites
KW - Peanuts
KW - Resveratrol
KW - Phytoalexins
KW - Polygonum
KW - dietary supplements
KW - intestinal bacteria
KW - phytochemicals
KW - resveratrol
KW - stilbenes
N1 - Accession Number: 43112734; Jung, Carina M. 1; Heinze, Thomas M. 2; Schnackenberg, Laura K. 3; Mullis, Lisa B. 4; Elkins, Stephanie A. 4; Elkins, Christopher A. 5; Steele, Roger S. 4; Sutherland, John B. 4; Email Address: john.sutherland@fda.hhs.gov; Affiliations: 1: US Army Engineer Research and Development Center, Vicksburg, MS, USA.; 2: National Center for Toxicological Research, Division of Biochemical Toxicology, US Food and Drug Administration, Jefferson, AR, USA.; 3: National Center for Toxicological Research, Division of Systems Toxicology, US Food and Drug Administration, Jefferson, AR, USA.; 4: National Center for Toxicological Research, Division of Microbiology, US Food and Drug Administration, Jefferson, AR, USA.; 5: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA.; Issue Info: Aug2009, Vol. 297 Issue 2, p266; Thesaurus Term: Bacteria; Thesaurus Term: Antifungal agents; Thesaurus Term: Biotransformation (Metabolism); Thesaurus Term: Antibacterial agents; Thesaurus Term: Metabolites; Thesaurus Term: Peanuts; Subject Term: Resveratrol; Subject Term: Phytoalexins; Subject Term: Polygonum; Author-Supplied Keyword: dietary supplements; Author-Supplied Keyword: intestinal bacteria; Author-Supplied Keyword: phytochemicals; Author-Supplied Keyword: resveratrol; Author-Supplied Keyword: stilbenes; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 115113 Crop Harvesting, Primarily by Machine; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 111992 Peanut Farming; NAICS/Industry Codes: 411190 Other farm product merchant wholesalers; Number of Pages: 8p; Document Type: Article
L3 - 10.1111/j.1574-6968.2009.01691.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43112734&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sun, Jinchun
AU - Von Tungeln, Linda S.
AU - Hines, Wade
AU - Beger, Richard D.
T1 - Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/08/15/
VL - 877
IS - 24
M3 - Article
SP - 2557
EP - 2565
SN - 15700232
AB - Abstract: The process of drug metabolite identification is extremely important for drug efficacy, safety and pharmacokinetics. The traditional method usually involves using a drug with a radioactive labeled nuclei and/or isolating major drug metabolites by HPLC before applying MS and NMR analyses, which requires trained specialists to handle the radioactive compounds and is time consuming for offline-HPLC separation. A method using mass spectrometry-based metabonomics combined with multivariate statistical analysis was applied to rapidly identify metabolite profiles of tolcapone, a catechol-O-methyl transferase inhibitor for Parkinson''s disease treatment. The tolcapone metabolites were identified based on the accurate mass measurement (<3ppm) and MS2 mass spectrum. In total, 16 tolcapone metabolites were detected and identified, 6 of which have not been reported previously. Our results indicate that the method has the capability to accelerate the process of identifying drug metabolites, ultimately reduce drug development costs, and make the process safer without requiring a drug with radioactive nuclei. Most importantly, the assay can detect the major and minor drug metabolites in a global view. Furthermore, since tolcapone has been associated with idiosyncratic drug induced liver toxicity the rapid detection of tolcapone-related metabolites can provide mechanistic toxicity information related to drug metabolism and the formation of reactive drug metabolites. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Analysis
KW - METABOLITES
KW - URINALYSIS
KW - ENZYME inhibitors
KW - HIGH performance liquid chromatography
KW - DRUGS -- Effectiveness
KW - PHARMACOKINETICS
KW - RADIOACTIVE tracers
KW - RATS as laboratory animals
KW - catechol-O-methyl transferase ( COMT )
KW - liver toxicity biomarker study ( LTBS )
KW - Metabolite/metabolism
KW - Metabonomics
KW - Parkinson's disease ( PD )
KW - principal component analysis ( PCA )
KW - Tolcapone
KW - total ion chromatograms ( TIC )
KW - ultra performance liquid chromatography/mass spectrometry ( UPLC/MS )
KW - UPLC/MS
KW - Urine
N1 - Accession Number: 43412155; Sun, Jinchun 1 Von Tungeln, Linda S. 2 Hines, Wade 3 Beger, Richard D. 1; Email Address: Richard.Beger@fda.hhs.gov; Affiliation: 1: Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA 2: Division of Biochemical Toxicology, NCTR, FDA, Jefferson, AR 72079, USA 3: BG Medicine, Waltham, MA 02451, USA; Source Info: Aug2009, Vol. 877 Issue 24, p2557; Subject Term: DRUGS -- Analysis; Subject Term: METABOLITES; Subject Term: URINALYSIS; Subject Term: ENZYME inhibitors; Subject Term: HIGH performance liquid chromatography; Subject Term: DRUGS -- Effectiveness; Subject Term: PHARMACOKINETICS; Subject Term: RADIOACTIVE tracers; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: catechol-O-methyl transferase ( COMT ); Author-Supplied Keyword: liver toxicity biomarker study ( LTBS ); Author-Supplied Keyword: Metabolite/metabolism; Author-Supplied Keyword: Metabonomics; Author-Supplied Keyword: Parkinson's disease ( PD ); Author-Supplied Keyword: principal component analysis ( PCA ); Author-Supplied Keyword: Tolcapone; Author-Supplied Keyword: total ion chromatograms ( TIC ); Author-Supplied Keyword: ultra performance liquid chromatography/mass spectrometry ( UPLC/MS ); Author-Supplied Keyword: UPLC/MS; Author-Supplied Keyword: Urine; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.jchromb.2009.06.033
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43412155&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - ABST
AU - Imai, Yumi
AU - Apakupakul, Kathleen
AU - Krause, Philip R.
AU - Halford, William P.
AU - Margolis, Todd P.
T1 - Investigation of the Mechanism by Which Herpes Simplex Virus Type 1 LAT Sequences Modulate Preferential Establishment of Latent Infection in Mouse Trigeminal Ganglia.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/08/15/
VL - 83
IS - 16
M3 - Abstract
SP - 7873
EP - 7882
SN - 0022538X
AB - We previously demonstrated that herpes simplex virus type 1 (HSV-1) preferentially establishes latent infection in monoclonal antibody (MAb) A5-positive ganglionic neurons and that a 2.8-kb portion of the HSV-1 genome, corresponding to the 5′ end of the LAT (latency-associated transcript) coding region, is responsible for this phenotype (38, 65). In the current study we carried out further genetic mapping of this latency phenotype and investigated some of the mechanisms that might be responsible. Studies with the chimeric virus HSV-1 17syn+/LAT2, an HSV-1 virus engineered to express HSV-2 LAT, demonstrated that this virus exhibited an HSV-2 latency phenotype, preferentially establishing latency in MAb KH10-positive neurons. This result is complementary to that previously described for the chimeric virus HSV-2 333/LAT1 and indicate that the HSV-1 latency phenotype can be changed to that of HSV-2 by substitution of a 2.8-kb piece of complementary viral DNA. Sequential studies in which we evaluated the pattern of HSV-1 latent infection of the mouse trigeminal ganglion following ocular inoculation with viruses with deletions of functional thymidine kinase, glycoprotein E, ICP0, and US9 protein demonstrate that preferential establishment of HSV-1 latent infection in A5-positive neurons is not a consequence of (i) differential access of HSV-1 to A5-positive neurons,(ii) differential cell-to-cell spread of HSV-1 to A5-positive neurons, (iii) differential "round-trip" spread of HSV-1 to A5-positive neurons, or (iv) expression of ICP0. Additional mapping studies with the HSV-1 LAT deletion viruses dLAT371, 17ΔSty, and 17Δ348 indicate that most of the LAT 5′ exon is not required for HSV-1 to preferentially establish latent infection in A5-positive neurons. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HERPES simplex virus
KW - MONOCLONAL antibodies
KW - NEURONS
KW - GENE mapping
KW - MEDICAL research
KW - ANIMAL experimentation
N1 - Accession Number: 44109082; Imai, Yumi 1 Apakupakul, Kathleen 1 Krause, Philip R. 2 Halford, William P. 3 Margolis, Todd P. 1,4; Email Address: todd.margolis@ucsf.edu; Affiliation: 1: F. I. Proctor Foundation, University of California at San Francisco, San Francisco, California 2: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 3: Department of Microbiology and Immunology, Southern Illinois University, School of Medicine, Springfield, Illinois 4: Department of Ophthalmology, University of California at San Francisco, San Francisco, California; Source Info: Aug2009, Vol. 83 Issue 16, p7873; Subject Term: HERPES simplex virus; Subject Term: MONOCLONAL antibodies; Subject Term: NEURONS; Subject Term: GENE mapping; Subject Term: MEDICAL research; Subject Term: ANIMAL experimentation; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 10p; Document Type: Abstract
L3 - 10.1128/JVI.00043-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44109082&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105407217
T1 - Treatments for nicotine addiction should be a top priority.
AU - Pollock JD
AU - Koustova E
AU - Hoffman A
AU - Shurtleff D
AU - Volkow ND
AU - Pollock, Jonathan D
AU - Koustova, Elena
AU - Hoffman, Allison
AU - Shurtleff, David
AU - Volkow, Nora D
Y1 - 2009/08/15/
N1 - Accession Number: 105407217. Language: English. Entry Date: 20090911. Revision Date: 20161119. Publication Type: journal article. Journal Subset: Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Grant Information: Z99 DA999999//Intramural NIH HHS/United States. NLM UID: 2985213R.
KW - Health and Welfare Planning
KW - Health Services Needs and Demand
KW - Substance Use Disorders -- Therapy
KW - Cause of Death
KW - Health Initiative 2000
KW - Research Support
KW - Smoking Cessation
KW - Substance Use Disorders -- Complications
KW - Substance Use Disorders -- Epidemiology
KW - United States
SP - 513
EP - 514
JO - Lancet
JF - Lancet
JA - LANCET
VL - 374 North American Edition
IS - 9689
CY - Philadelphia, Pennsylvania
PB - Lancet
SN - 0099-5355
AD - National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
AD - National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
U2 - PMID: 19394686.
DO - 10.1016/S0140-6736(09)60352-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105407217&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Cho, Minjung
AU - Kim, Seoung Ryul
AU - Choi, Mina
AU - Lee, Jeong Yeon
AU - Han, Beom Seok
AU - Park, Sue Nie
AU - Yu, Mi Kyung
AU - Jon, Sangyong
AU - Jeong, Jayoung
T1 - Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/08/15/
VL - 239
IS - 1
M3 - Article
SP - 106
EP - 115
SN - 0041008X
AB - Abstract: Recent advances in the development of nanotechnology and devices now make it possible to accurately deliver drugs or genes to the lung. Magnetic nanoparticles can be used as contrast agents, thermal therapy for cancer, and be made to concentrate to target sites through an external magnetic field. However, these advantages may also become problematic when taking into account safety and toxicological factors. This study demonstrated the pulmonary toxicity and kinetic profile of anti-biofouling polymer coated, Cy5.5-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) by optical imaging. Negatively charged, 36 nm-sized, Cy5.5-conjugated TCL-SPION was prepared for optical imaging probe. Cy5.5-conjugated TCL-SPION was intratracheally instilled into the lung by a non-surgical method. Cy5.5-conjugated TCL-SPION slightly induced pulmonary inflammation. The instilled nanoparticles were distributed mainly in the lung and excreted in the urine via glomerular filtration. Urinary excretion was peaked at 3 h after instillation. No toxicity was found under the concentration of 1.8 mg/kg and the half-lives of nanoparticles in the lung and urine were estimated to be about 14.4±0.54 h and 24.7±1.02 h, respectively. Although further studies are required, our results showed that Cy5.5-conjugated TCL-SPION can be a good candidate for use in pulmonary delivery vehicles and diagnostic probes. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PULMONARY toxicology
KW - IRON oxides -- Magnetic properties
KW - NANOPARTICLES
KW - DRUG delivery systems
KW - CONTRAST media (Diagnostic imaging)
KW - CANCER -- Thermotherapy
KW - INFLAMMATION
KW - Extrapulmonary translocation
KW - Inflammation
KW - Intratracheal instillation
KW - Kinetic
KW - Thermally cross-linked superparamagnetic iron oxide nanoparticles
N1 - Accession Number: 43416406; Cho, Wan-Seob 1,2; Email Address: chows77@hotmail.com Cho, Minjung 1 Kim, Seoung Ryul 1 Choi, Mina 1 Lee, Jeong Yeon 1 Han, Beom Seok 1 Park, Sue Nie 3 Yu, Mi Kyung 4 Jon, Sangyong 4 Jeong, Jayoung 1; Affiliation: 1: Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea 2: Respiratory Medicine Unit, ELEGI/Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK 3: Division of Genetic Toxicology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea 4: Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea; Source Info: Aug2009, Vol. 239 Issue 1, p106; Subject Term: PULMONARY toxicology; Subject Term: IRON oxides -- Magnetic properties; Subject Term: NANOPARTICLES; Subject Term: DRUG delivery systems; Subject Term: CONTRAST media (Diagnostic imaging); Subject Term: CANCER -- Thermotherapy; Subject Term: INFLAMMATION; Author-Supplied Keyword: Extrapulmonary translocation; Author-Supplied Keyword: Inflammation; Author-Supplied Keyword: Intratracheal instillation; Author-Supplied Keyword: Kinetic; Author-Supplied Keyword: Thermally cross-linked superparamagnetic iron oxide nanoparticles; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2009.05.026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43416406&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-18404-001
AN - 2009-18404-001
AU - Pollock, Jonathan
AU - Koustava, Elena
AU - Hoffman, Allison
AU - Shurtleff, David
AU - Volkow, Nora D.
T1 - Treatments for nicotine addiction should be a top priority.
JF - The Lancet
JO - The Lancet
JA - Lancet
Y1 - 2009/08/15/
VL - 374
IS - 9689
SP - 513
EP - 514
CY - United Kingdom
PB - Lancet
SN - 0140-6736
SN - 1474-547X
AD - Pollock, Jonathan, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US, 20892
N1 - Accession Number: 2009-18404-001. PMID: 19394686 Partial author list: First Author & Affiliation: Pollock, Jonathan; National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, US. Release Date: 20091207. Correction Date: 20150413. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Addiction; Neoplasms; Nicotine; Smoking Cessation; Treatment. Minor Descriptor: Lung; Tobacco Smoking. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Location: US. References Available: Y. Page Count: 2. Issue Publication Date: Aug 15, 2009.
AB - Priorities for investment in clinical trials are directed at treatment of diseases caused by continued tobacco use, rather than addressing the root cause of the diseases: nicotine addiction. Moreover, clinical trials for smoking cessation and treatment of nicotine addiction are not even within the top 25 therapeutic categories in development by the drug industry; anticancer treatments are the first priority. 174 pharmacotherapy trials were done for smoking cessation (46 supported by industry) compared with 1490 for lung cancer (544 supported by industry). Despite enormous efforts to find treatments for lung cancer, the 5-year survival rate has increased from 6% to only 14%, and incidence and mortality have increased 2.5-fold during the same period. Incorporation of tobacco dependence into a conceptual model of chronic disease will be of profound and immediate benefit to public health. Furthermore, research findings should be used to identify new molecular targets for nicotine addiction and biomarkers to predict treatment success. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - nicotine addiction
KW - smoking cessation
KW - tobacco use
KW - lung cancer
KW - treatment
KW - 2009
KW - Drug Addiction
KW - Neoplasms
KW - Nicotine
KW - Smoking Cessation
KW - Treatment
KW - Lung
KW - Tobacco Smoking
KW - 2009
DO - 10.1016/S0140-6736(09)60352-4
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18404-001&site=ehost-live&scope=site
UR - jpollock@mail.nih.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Abraham, Sherwin J.
AU - Nolet, Ryan P.
AU - CaIvert, Richard J.
AU - Anderson, Lucy M.
AU - Gaponenko, Vadim
T1 - The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin.
JO - Biochemistry
JF - Biochemistry
Y1 - 2009/08/18/
VL - 48
IS - 32
M3 - Article
SP - 7575
EP - 7583
SN - 00062960
AB - K-Ras4B belongs to the family of p21 Ras GTPases, which play an important role in cell proliferation, survival, and motility. The p21 Ras proteins, such as K-Ras4B, K-Ras4A, H-Ras, and N-Ras, share 85% sequence homology and activate very similar signaling pathways. Only the C-terminal hypervariable regions differ significantly. A growing body of literature demonstrates that each Ras isoform possesses unique functions in normal physiological processes as well as in pathogenesis. One of the central questions in the field of Ras biology is how these very similar proteins achieve such remarkable specificity in protein-protein interactions that regulate signal transduction pathways. Here we explore specific binding of K-Ras4B to calmodulin. Using NMR techniques and isothermal titration calorimetry, we demonstrate that the hypervariable region of K-Ras4B contributes in a major way to the interaction with calmodulin, while the catalytic domain of K-Ras4H provides a way to control the interaction by nucleotide binding. The hypervariable region of K-Ras4B binds specifically to the C-terminal domain of Ca2+-loaded calmodulin with micromolar affinity, while the GTP-γ-S-loaded catalytic domain of K-Ras4B may interact with the N-terminal domain of calmodulin. [ABSTRACT FROM AUTHOR]
AB - Copyright of Biochemistry is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HUMAN genome -- Hypervariable regions
KW - CALMODULIN
KW - CELL proliferation
KW - RAS proteins
KW - HOMOLOGY (Biology)
KW - PROTEIN-protein interactions
KW - GENETIC transduction
N1 - Accession Number: 43914527; Abraham, Sherwin J. 1 Nolet, Ryan P. 1 CaIvert, Richard J. 2,3 Anderson, Lucy M. 2 Gaponenko, Vadim 1; Email Address: vadimg@uic.edu; Affiliation: 1: Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607 2: Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland 21702 3: Division of Bioanalytical Chemistry, U.S. Food and Drug Administration, College Park, Maryland 20740; Source Info: 8/18/2009, Vol. 48 Issue 32, p7575; Subject Term: HUMAN genome -- Hypervariable regions; Subject Term: CALMODULIN; Subject Term: CELL proliferation; Subject Term: RAS proteins; Subject Term: HOMOLOGY (Biology); Subject Term: PROTEIN-protein interactions; Subject Term: GENETIC transduction; Number of Pages: 9p; Document Type: Article
L3 - 10.1021/bi900769j
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43914527&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Slade, Barbara A.
AU - Leidel, Laura
AU - Vellozzi, Claudia
AU - Woo, Emily Jane
AU - Wei Hua
AU - Sutherland, Andrea
AU - Izurieta, Hector S.
AU - Ball, Robert
AU - Miller, Nancy
AU - Braun, M. Miles
AU - Markowitz, Lauri E.
AU - Iskander, John
T1 - Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus Recombinant Vaccine.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/08/19/
VL - 302
IS - 7
M3 - Article
SP - 750
EP - 757
SN - 00987484
AB - The article focuses on a study which summarized data from the U.S. Vaccine Adverse Event Reporting System (VAERS) following receipt of recombinant human papillomavirus vaccine (qHPV). The qHPV reports received by VAERS from June 1, 2006 to December 31, 2008 were analyzed. A total of 12,424 reports of adverse events following immunization (AEFIs) was received by VAERS. The AEFIs reported include syncope, local site reactions, nausea and headache. It also noted a disproportional reporting of syncope and venous thromboembolic events.
KW - VACCINATION -- Complications
KW - PAPILLOMAVIRUS diseases -- Vaccination
KW - VIRAL vaccines
KW - COMMUNICABLE diseases -- Prevention
KW - UNITED States
N1 - Accession Number: 43788485; Slade, Barbara A. 1; Email Address: bfs9@cdc.gov Leidel, Laura 1 Vellozzi, Claudia 1 Woo, Emily Jane 2 Wei Hua 2 Sutherland, Andrea 2 Izurieta, Hector S. 2 Ball, Robert 2 Miller, Nancy 2 Braun, M. Miles 2 Markowitz, Lauri E. 1 Iskander, John 1; Affiliation: 1: Centers for Disease Control and Prevention, Atlanta, Georgia 2: US Food and Drug Administration, Washington, DC; Source Info: 8/19/2009, Vol. 302 Issue 7, p750; Subject Term: VACCINATION -- Complications; Subject Term: PAPILLOMAVIRUS diseases -- Vaccination; Subject Term: VIRAL vaccines; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: UNITED States; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ham, Jason E.
AU - Raymond Wells, J.
T1 - Surface chemistry of dihydromyrcenol (2,6-dimethyl-7-octen-2-ol) with ozone on silanized glass, glass, and vinyl flooring tiles
JO - Atmospheric Environment
JF - Atmospheric Environment
Y1 - 2009/08/21/
VL - 43
IS - 26
M3 - Article
SP - 4023
EP - 4032
SN - 13522310
AB - Abstract: The surface-phase reaction products of dihydromyrcenol (2,6-dimethyl-7-octen-2-ol) with ozone (O3), air, or nitrogen (N2) on silanized glass, glass and vinyl flooring tile were investigated using the recently published FACS (FLEC (Field and Laboratory Emission Cell) Automation and Control System). The FACS was used to deliver ozone (100 ppb), air, or N2 to the surface at a specified flow rate (300 mL min−1) and relative humidity (50%) after application of a 2.0% dihydromyrcenol solution in methanol. Oxidation products were detected using the derivatization agents: O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) and N,O-bis(trimethysilyl)trifluoroacetamide (BSTFA). The positively identified reaction products were glycolaldehyde, 2,6-dimethyl-5-heptenal, and glyoxal. The proposed oxidation products based on previously published VOC/O3 reaction mechanisms were: 2,6-dimethyl-4-heptenal, 6-methyl-7-octen-2-one and the surface-specific reaction products: 6-methyl-6-hepten-2-one, 6-methyl-5-hepten-2-one, and 6-hydroxy-6-methylheptan-2-one. Though similar products were observed in gas-phase dihydromyrcenol/O3 reactions, the ratio, based on peak area, of the reaction products was different suggesting stabilization of larger molecular weight species by the surface. Emission profiles of these oxidation products over 72 h are also reported. [Copyright &y& Elsevier]
AB - Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Surface chemistry
KW - Ozone
KW - Humidity
KW - Emissions (Air pollution)
KW - Oxidation
KW - Odors
KW - Glass
KW - Tiles
KW - Chemical reactions
KW - Industrial engineering
KW - Dihydromyrcenol
KW - Reaction products
N1 - Accession Number: 43340601; Ham, Jason E.; Email Address: bvo2@cdc.gov; Raymond Wells, J. 1; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Issue Info: Aug2009, Vol. 43 Issue 26, p4023; Thesaurus Term: Surface chemistry; Thesaurus Term: Ozone; Thesaurus Term: Humidity; Thesaurus Term: Emissions (Air pollution); Thesaurus Term: Oxidation; Subject Term: Odors; Subject Term: Glass; Subject Term: Tiles; Subject Term: Chemical reactions; Subject Term: Industrial engineering; Author-Supplied Keyword: Dihydromyrcenol; Author-Supplied Keyword: Reaction products; NAICS/Industry Codes: 327214 Glass manufacturing; NAICS/Industry Codes: 416340 Paint, glass and wallpaper merchant wholesalers; NAICS/Industry Codes: 238150 Glass and Glazing Contractors; NAICS/Industry Codes: 444190 Other Building Material Dealers; NAICS/Industry Codes: 416390 Other specialty-line building supplies merchant wholesalers; NAICS/Industry Codes: 327120 Clay Building Material and Refractories Manufacturing; NAICS/Industry Codes: 238340 Tile and Terrazzo Contractors; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.atmosenv.2009.05.007
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43340601&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105441899
T1 - Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration.
AU - Stone M
AU - Laughren T
AU - Jones ML
AU - Levenson M
AU - Holland PC
AU - Hughes A
AU - Hammad TA
AU - Temple R
AU - Rochester G
Y1 - 2009/08/22/
N1 - Accession Number: 105441899. Language: English. Entry Date: 20091106. Revision Date: 20150711. Publication Type: Journal Article; clinical trial; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 101090866.
KW - Antidepressive Agents -- Adverse Effects
KW - Data Analysis -- Methods
KW - Suicidal Ideation -- Prevention and Control
KW - United States Food and Drug Administration -- Standards
KW - Antidepressive Agents -- Therapeutic Use
KW - Clinical Trials
KW - Logistic Regression
KW - Outcomes (Health Care)
KW - Human
SP - 431
EP - 434
JO - BMJ: British Medical Journal (Overseas & Retired Doctors Edition)
JF - BMJ: British Medical Journal (Overseas & Retired Doctors Edition)
JA - BMJ BR MED J (OVERSEAS & RETIRED DOCTORS ED)
VL - 339
IS - 7718
PB - BMJ Publishing Group
SN - 1759-2151
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002l; marc.stone@fda.hhs.gov
U2 - PMID: 19671933.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105441899&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-13417-001
AN - 2009-13417-001
AU - Stone, Marc
AU - Laughren, Thomas
AU - Jones, M. Lisa
AU - Levenson, Mark
AU - Holland, P. Chris
AU - Hughes, Alice
AU - Hammad, Tarek A.
AU - Temple, Robert
AU - Rochester, George
T1 - Risk of suicidality in clinical trials of antidepressants in adults: Analysis of proprietary data submitted to US Food and Drug Administration.
JF - BMJ: British Medical Journal
JO - BMJ: British Medical Journal
JA - BMJ
Y1 - 2009/08/22/
VL - 339
IS - 7718
CY - United Kingdom
PB - BMJ Publishing Group
SN - 0959-8138
SN - 1756-1833
AD - Stone, Marc, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, US, 20993-0002
N1 - Accession Number: 2009-13417-001. Partial author list: First Author & Affiliation: Stone, Marc; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, US. Release Date: 20091012. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Clinical Trials; Epidemiology; Side Effects (Drug); Suicidal Ideation. Minor Descriptor: Drug Therapy. Classification: Clinical Psychopharmacology (3340). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300). Methodology: Meta Analysis. References Available: Y. Issue Publication Date: Aug 22, 2009. Publication History: First Posted Date: Aug 11, 2009; Accepted Date: May 1, 2009. Copyright Statement: BMJ Publishing Group Ltd. 2009.
AB - Objective: To examine the risk of suicidal behavior within clinical trials of antidepressants in adults. Design: Meta-analysis of 372 double blind randomized placebo controlled trials. Setting: Drug development programs for any indication in adults. Participants: 99 231 adults assigned to antidepressants or placebo. Median age was 42 and 63.1% were women. Indications for treatment were major depression (45.6%), other depression (4.6%), other psychiatric disorders (27.6%), and nonpsychiatric disorders (22.2%). Main outcome measures: Suicidal behavior (completed suicide, attempted suicide, or preparatory acts) and ideation. Results: For participants with non-psychiatric indications, suicidal behavior and ideation were extremely rare. For those with psychiatric indications, risk was associated with age. For suicidal behavior or ideation and for suicidal behavior only, the respective odds ratios were 1.62 (95% confidence interval 0.97 to 2.71) and 2.30 (1.04 to 5.09) for participants aged <25, 0.79 (0.64 to 0.98) and 0.87 (0.58 to 1.29) for those aged 25-64, and 0.37 (0.18 to 0.76) and 0.06 (0.01 to 0.58) for those aged ≥65. When age was modeled as a continuous variable, the odds ratio for suicidal behavior or ideation declined at a rate of 2.6% per year of age (−3.9% to −1.3%, P = 0.0001) and the odds ratio for suicidal behavior declined at a rate of 4.6% per year of age (−7.4% to −1.8%, P = 0.001). Conclusions: Risk of suicidality associated with use of antidepressants is strongly age dependent. Compared with placebo, the increased risk for suicidality and suicidal behavior among adults under 25 approaches that seen in children and adolescents. The net effect seems to be neutral on suicidal behavior but possibly protective for suicidal ideation in adults aged 25-64 and to reduce the risk of both suicidality and suicidal behavior in those aged ≥65. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - risk of suicidal behavior
KW - clinical trials
KW - antidepressants
KW - 2009
KW - Antidepressant Drugs
KW - Clinical Trials
KW - Epidemiology
KW - Side Effects (Drug)
KW - Suicidal Ideation
KW - Drug Therapy
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13417-001&site=ehost-live&scope=site
UR - marc.stone@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Jaekwang Kim
AU - Sang Ick Park
AU - Chiyoung Ahn
AU - Heuijong Kim
AU - Jeong bin Yim
T1 - Guanine Deaminase Functions as Dihydropterin Deaminase in the Biosynthesis of Aurodrosopterin, a Minor Red Eye Pigment of Drosophila.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/08/28/
VL - 284
IS - 35
M3 - Article
SP - 23426
EP - 23435
SN - 00219258
AB - Dihydropterin deaminase, which catalyzes the conversion of 7,8-dihydropterin to 7,8-dihydrolumazine, was purified 5850-fold to apparent homogeneity from Drosophila melanogaster. Its molecular mass was estimated to be 48 kDa by gel filtration and SDS-PAGE, indicating that it is a monomer under native conditions. The pI value, temperature, and optimal pH of the enzyme were 5.5, 40 °C, and 7.5, respectively. Interestingly the enzyme had much higher activity for guanine than for 7,8-dihydropterin. The specificity constant (kcat/Km) for guanine (8.6 × 106 M-1·s-1) was 860-fold higher than that for 7,8-dihydropterin (1.0 × 104 M-1·s-1). The structural gene of the enzyme was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis as CG18143, located at region 82A1 on chromosome 3R. The cloned and expressed CG18143 exhibited both 7,8-dihydropterin and guanine deaminase activities. Flies with mutations in CG18143, SIJPor-P/Df(3R)A321R1 transheterozygotes, had severely decreased activities in both deaminases compared with the wild type. Among several red eye pigments, the level of aurodrosopterin was specifically decreased in the mutant, and the amount of xanthine and uric acid also decreased considerably to 76 and 59% of the amounts in the wild type, respectively. In conclusion, dihydropterin deaminase encoded by CG18143 plays a role in the biosynthesis of aurodrosopterin by providing one of its precursors, 7,8-dihydrolumazine, from 7,8-dihydropterin. Dihydropterin deaminase also functions as guanine deaminase, an important enzyme for purine metabolism. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DROSOPHILA melanogaster
KW - BIOSYNTHESIS
KW - COLLOIDS
KW - URIC acid
KW - SPECTRUM analysis
KW - DROSOPHILA
N1 - Accession Number: 44297553; Jaekwang Kim 1 Sang Ick Park 2 Chiyoung Ahn 3 Heuijong Kim 1 Jeong bin Yim 1; Email Address: jyim@snu.ac.kr; Affiliation: 1: School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. 2: Division of Intractable Diseases, Center for Biomedical Sciences, National Institutes of Health, Seoul 122-701, Korea. 3: Advanced Therapy Products Division, Biopharmaceuticals and Herbal Medicine Bureau, Korea Food and Drug Administration, Seoul 122-704, Korea.; Source Info: 8/28/2009, Vol. 284 Issue 35, p23426; Subject Term: DROSOPHILA melanogaster; Subject Term: BIOSYNTHESIS; Subject Term: COLLOIDS; Subject Term: URIC acid; Subject Term: SPECTRUM analysis; Subject Term: DROSOPHILA; Number of Pages: 10p; Document Type: Article
L3 - 10.1074/jbc.M109.016493
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44297553&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-12029-014
AN - 2009-12029-014
AU - Violanti, John M.
AU - Burchfiel, Cecil M.
AU - Fekedulegn, Desta
AU - Andrew, Michael E.
AU - Dorn, Joan
AU - Hartley, Tara A.
AU - Charles, Luenda E.
AU - Miller, Diane B.
T1 - Cortisol patterns and brachial artery reactivity in a high stress environment.
JF - Psychiatry Research
JO - Psychiatry Research
JA - Psychiatry Res
Y1 - 2009/08/30/
VL - 169
IS - 1
SP - 75
EP - 81
CY - Netherlands
PB - Elsevier Science
SN - 0165-1781
AD - Violanti, John M., Department of Social and Preventive Medicine, State University of NY at Buffalo, 270 Farber Hall, Buffalo, NY, US, 14214
N1 - Accession Number: 2009-12029-014. PMID: 19616310 Partial author list: First Author & Affiliation: Violanti, John M.; School of Public Health and Health Professions, Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, US. Release Date: 20090928. Correction Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Arteries (Anatomy); Chronic Stress; Environment; Hydrocortisone. Minor Descriptor: Biological Markers; Cardiovascular Disorders; Police Personnel; Risk Factors. Classification: Psychophysiology (2560). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Aug 30, 2009. Publication History: Accepted Date: Jun 12, 2008; Revised Date: Sep 4, 2007; First Submitted Date: Jan 10, 2007. Copyright Statement: All rights reserved. Elsevier Ireland Ltd. 2008.
AB - Chronic stress can result in frequent or persistent challenges of the hypothalamic-pituitary-adrenal (HPA) axis resulting in abnormal cortisol patterns and increased risk for cardiovascular disease (CVD). Police work is an environment replete with stress. The present article describes associations between cortisol, a biomarker of stress, and brachial artery flow mediated dilation (FMD) in police officers. A random sample stratified on gender (n = 100, 33% women) was generated from officers in a mid-sized urban department. Four salivary cortisol parameters were derived: after awakening, following a standardized high protein meal challenge, during the entire day, and after a dexamethasone suppression test. Continuous scan B-Mode ultrasound was used to measure percent change in brachial artery FMD following occlusion and release. Elevated cortisol secretion after awakening was significantly associated with impaired FMD in women, reflected by an inverse trend. Adjustment for age, smoking, and alcohol consumption did not appreciably alter this trend. A similar result was not evident among male officers. Responses of other cortisol challenges to the HPA axis were not associated with FMD. In conclusion, increased cortisol secretion after awakening was independently associated with impaired FMD in female police officers only, indicating a possible link between HPA axis stress response and subclinical CVD. However, because associations were not found with other cortisol parameters and were not evident in male officers, replication of these findings with a prospective study design may be warranted. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - cortisol patterns
KW - brachial artery reactivity
KW - chronic stress environment
KW - biomarker
KW - flow mediated dilation
KW - police officers
KW - risk factors
KW - cardiovascular disease
KW - 2009
KW - Arteries (Anatomy)
KW - Chronic Stress
KW - Environment
KW - Hydrocortisone
KW - Biological Markers
KW - Cardiovascular Disorders
KW - Police Personnel
KW - Risk Factors
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health, US. Grant: HELD01B0088. Recipients: No recipient indicated
DO - 10.1016/j.psychres.2008.06.012
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-12029-014&site=ehost-live&scope=site
UR - violanti@buffalo.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105401316
T1 - Investigation of reading mode and relative sensitivity as factors that influence reader performance when using computer-aided detection software.
AU - Paquerault S
AU - Samuelson FW
AU - Petrick N
AU - Myers KJ
AU - Smith RC
Y1 - 2009/09//
N1 - Accession Number: 105401316. Language: English. Entry Date: 20091106. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Diagnostic Imaging. NLM UID: 9440159.
KW - Algorithms
KW - Artifacts
KW - Breast Neoplasms -- Radiography
KW - Information Science -- Methods
KW - Mammography -- Methods
KW - Radiographic Image Interpretation, Computer-Assisted -- Methods
KW - Software
KW - Artificial Intelligence
KW - Female
KW - Observer Bias
KW - Radiographic Image Enhancement -- Methods
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Human
SP - 1095
EP - 1107
JO - Academic Radiology
JF - Academic Radiology
JA - ACAD RADIOL
VL - 16
IS - 9
CY - New York, New York
PB - Elsevier Science
SN - 1076-6332
AD - Center for Devices and Radiological Health/National Insitute of Biomedical Imaging and Bioengineering, Joint Laboratory for Assessment of Medical Imaging Systems, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA. sophie.paquerault@fda.hhs.gov
U2 - PMID: 19523855.
DO - 10.1016/j.acra.2009.03.024
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105401316&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Park, Robert M.
AU - Bushnell, P. Timothy
AU - Bailer, A. John
AU - Collins, James W.
AU - Stayner, Leslie T.
T1 - Impact of Publicly Sponsored Interventions on Musculoskeletal Injury Claims in Nursing Homes.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/09//
VL - 52
IS - 9
M3 - Article
SP - 683
EP - 697
SN - 02713586
AB - The article presents a study which analyzes the impact of the sponsored interventions of the Ohio Bureau of Workers' Compensation (BWC) on back injury claims in Ohio nursing homes. It notes that BWC data on claims, interventions, and employer payroll for all nursing homes for 1995-2004 were used to identify the relationship. Results show that a 21% reduction in back injury rate is associated with a 500-dollar equipment purchase per nursing home worker.
KW - Backache -- Treatment
KW - Nursing care facilities -- Finance
KW - Ohio. Bureau of Workers' Compensation
KW - Federal aid to health facilities
KW - Medical equipment
KW - Medical personnel -- Salaries, etc.
KW - Ohio
KW - certified nursing aide
KW - consultation
KW - ergonomics
KW - injury costs
KW - resident acuity
KW - staffing ratio
KW - training courses
N1 - Accession Number: 44180727; Park, Robert M. 1; Email Address: rhp9@cdc.gov; Bushnell, P. Timothy 2; Bailer, A. John 1,3; Collins, James W. 4; Stayner, Leslie T. 5; Affiliations: 1: Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 2: Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio; 3: Department of Statistics, Scripps Gerontology Center, Miami University, Oxford, Ohio; 4: Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia; 5: Department of Epidemiology, School of Public Health, University of Illinois at Chicago, Chicago, Illinois; Issue Info: Sep2009, Vol. 52 Issue 9, p683; Subject Term: Backache -- Treatment; Subject Term: Nursing care facilities -- Finance; Subject Term: Ohio. Bureau of Workers' Compensation; Subject Term: Federal aid to health facilities; Subject Term: Medical equipment; Subject Term: Medical personnel -- Salaries, etc.; Subject: Ohio; Author-Supplied Keyword: certified nursing aide; Author-Supplied Keyword: consultation; Author-Supplied Keyword: ergonomics; Author-Supplied Keyword: injury costs; Author-Supplied Keyword: resident acuity; Author-Supplied Keyword: staffing ratio; Author-Supplied Keyword: training courses; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 339112 Surgical and Medical Instrument Manufacturing; NAICS/Industry Codes: 623110 Nursing Care Facilities (Skilled Nursing Facilities); NAICS/Industry Codes: 623310 Community care facilities for the elderly; Number of Pages: 15p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1002/ajim.20731
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Chen, Guang X.
T1 - Nonfatal Work-Related Motor Vehicle Injuries Treated in Emergency Departments in the United States, 1998-2002.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/09//
VL - 52
IS - 9
M3 - Article
SP - 698
EP - 706
SN - 02713586
AB - The article presents a study that estimates the occurrences and rates of nonfatal work-related motor vehicle injuries treated in hospital emergency department across industries and occupations in the U.S. from 1998-2002. It notes that the study used the National Electronic Injury Surveillance System (NEISS) to identify the people with injuries. It has found out that the average annual injury rate was 7 per 10,000 full-time equivalents and that injuries are three times higher in men than women.
KW - RESEARCH
KW - Work-related injuries
KW - Traffic accidents
KW - Occupations
KW - Hospital emergency services
KW - United States
KW - emergency department
KW - motor vehicle crash
KW - motor vehicle injury
KW - occupational injury
KW - surveillance
N1 - Accession Number: 44180728; Chen, Guang X. 1; Email Address: gchen@cdc.gov; Affiliations: 1: Analysis and Field Operations Branch, Division of Safety Research, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia; Issue Info: Sep2009, Vol. 52 Issue 9, p698; Thesaurus Term: RESEARCH; Subject Term: Work-related injuries; Subject Term: Traffic accidents; Subject Term: Occupations; Subject Term: Hospital emergency services; Subject: United States; Author-Supplied Keyword: emergency department; Author-Supplied Keyword: motor vehicle crash; Author-Supplied Keyword: motor vehicle injury; Author-Supplied Keyword: occupational injury; Author-Supplied Keyword: surveillance; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1002/ajim.20726
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DP - EBSCOhost
DB - eih
ER -
TY - GEN
AU - Guyatt, Gordon H.
AU - Helfand, Mark
AU - Kunz, Regina
AU - Petitti, Diana B.
AU - Teutsch, Steven M.
AU - Barton, Mary B.
AU - Sawaya, George F.
AU - Ockene, Judith K.
AU - DeWitt, Thomas
T1 - Comparing the USPSTF and GRADE Approaches to Recommendations.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/09//9/1/2009
VL - 151
IS - 5
M3 - Letter
SP - 363
EP - 364
SN - 00034819
AB - A letter to the editor in response to the article on insufficient evidence category of the U.S. Preventive Services Task Force (USPSTF) system and the author's reply to the letter are presented.
KW - LETTERS to the editor
KW - PREVENTIVE medicine
KW - MEDICAL care -- United States
KW - UNITED States
KW - U.S. Preventive Services Task Force
N1 - Accession Number: 44028601; Guyatt, Gordon H. 1 Helfand, Mark 2 Kunz, Regina 3 Petitti, Diana B. 4 Teutsch, Steven M. 5 Barton, Mary B. 6 Sawaya, George F. 7 Ockene, Judith K. 8 DeWitt, Thomas 9; Affiliation: 1: McMaster University Health Sciences Center, Hamilton, Ontario L8S 4L8, Canada 2: Portland Veterans Affairs Medical Center, Portland, OR 97239 3: University Hospital Basel, 4031 Basel, Switzerland 4: Arizona State University, Phoenix, AZ 85041 5: Los Angeles County Department of Public Health, Los Angeles, CA 90012 6: Agency for Healthcare Research and Quality, Rockville, MD 20850 7: University of California, San Francisco, San Francisco, CA 94143 8: University of Massachusetts Medical School, Worcester, MA 01655 9: University of Cincinnati College of Medicine, Cincinnati, OH 45229; Source Info: 9/1/2009, Vol. 151 Issue 5, p363; Subject Term: LETTERS to the editor; Subject Term: PREVENTIVE medicine; Subject Term: MEDICAL care -- United States; Subject Term: UNITED States; Company/Entity: U.S. Preventive Services Task Force; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Waterhouse, Joyce C.
AU - Perez, Thomas H.
AU - Albert, Paul J.
T1 - Reversing Bacteria-induced Vitamin D Receptor Dysfunction Is Key to Autoimmune Disease.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2009/09//
VL - 1173
M3 - Article
SP - 757
EP - 765
SN - 00778923
AB - Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. The VDR dysfunction causes a decline in innate immune function that causes susceptibility to additional infections that contribute to disease progression. Evidence has been accumulating that indicates that a number of autoimmune diseases can be reversed by gradually restoring VDR function with the VDR agonist olmesartan and subinhibitory dosages of certain bacteriostatic antibiotics. Diseases showing favorable responses to treatment so far include systemic lupus erythematosis, rheumatoid arthritis, scleroderma, sarcoidosis, Sjogren's syndrome, autoimmune thyroid disease, psoriasis, ankylosing spondylitis, Reiter's syndrome, type I and II diabetes mellitus, and uveitis. Disease reversal using this approach requires limitation of vitamin D in order to avoid contributing to dysfunction of nuclear receptors and subsequent negative consequences for immune and endocrine function. Immunopathological reactions accompanying bacterial cell death require a gradual elimination of pathogens over several years. Practical and theoretical implications are discussed, along with the compatibility of this model with current research. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - STEROID hormones
KW - CALCIUM regulating hormones
KW - RHEUMATOID arthritis
KW - COLLAGEN diseases
KW - AUTOIMMUNE diseases
KW - AUTOIMMUNITY
KW - 1
KW - 1,25-dihydroxyvitamin D
KW - 25- dihydroxyvitamin D
KW - 25-hydroxyvitamin D
KW - autoimmune diseases
KW - bacteria
KW - biofilm
KW - cholecalciferol
KW - immunosuppression
KW - L-form bacteria
KW - metagenomic
KW - natural immunity
KW - vitamin D
KW - vitamin D receptor
N1 - Accession Number: 43988093; Waterhouse, Joyce C. 1; Email Address: jcw@autoimmunityresearch.org Perez, Thomas H. 1,2 Albert, Paul J. 3; Affiliation: 1: Autoimmunity Research Foundation, Thousand Oaks, California, USA. 2: US Public Health Service. 3: Weill Cornell Medical College.; Source Info: Sep2009, Vol. 1173, p757; Subject Term: STEROID hormones; Subject Term: CALCIUM regulating hormones; Subject Term: RHEUMATOID arthritis; Subject Term: COLLAGEN diseases; Subject Term: AUTOIMMUNE diseases; Subject Term: AUTOIMMUNITY; Author-Supplied Keyword: 1; Author-Supplied Keyword: 1,25-dihydroxyvitamin D; Author-Supplied Keyword: 25- dihydroxyvitamin D; Author-Supplied Keyword: 25-hydroxyvitamin D; Author-Supplied Keyword: autoimmune diseases; Author-Supplied Keyword: bacteria; Author-Supplied Keyword: biofilm; Author-Supplied Keyword: cholecalciferol; Author-Supplied Keyword: immunosuppression; Author-Supplied Keyword: L-form bacteria; Author-Supplied Keyword: metagenomic; Author-Supplied Keyword: natural immunity; Author-Supplied Keyword: vitamin D; Author-Supplied Keyword: vitamin D receptor; Number of Pages: 9p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1749-6632.2009.04637.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - James-Ellison, M.
AU - Barnes, P.
AU - Maddocks, A.
AU - Wareham, K.
AU - Drew, P.
AU - Dickson, W.
AU - Lyons, R. A.
AU - Hutchings, H.
T1 - Social health outcomes following thermal injuries: a retrospective matched cohort study.
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
Y1 - 2009/09//
VL - 94
IS - 9
M3 - Article
SP - 663
EP - 667
SN - 00039888
AB - Introduction: Over 50% of children admitted with burns are aged under 3 years. US studies suggest that up to 26% of childhood burns are non-accidental, although UK reports are lower (1-16%). Objectives: To determine the social health outcomes of burned children as regards the number of children abused, neglected or "in need" before the age of 6 years compared with matched controls. Methods: A retrospective matched cohort study. 145 children aged under 3 years admitted for burns in 1994-1997 were matched with controls for sex, age and enumeration district and followed up until 2003. Electronic routine databases provided study data on local authority care episodes and Social Services referrals by age 6 years. Results: 89.0% of cases had accidental burns and four cases (2.8%) had non-accidental burns. No case was attributed to neglect. By their sixth birthday cases were statistically more likely to have been referred to Social Services with 14 (9.7%) of the burned children having been abused or neglected versus two (1.4%) controls (95% CI 0.030 to 0.13, p = 0.004). Forty six (32%) cases versus 26 (18%) controls were defined as "in need" (95% CI 0.047 to 0.23, p = 0.006). Conclusion: Although most burns were deemed accidental, 2.8% were categorised as non-accidental at presentation. Almost a third of the burned children went on to be "in need". Children with a burn appear to be at higher risk of further abuse or neglect compared with controls. A burn therefore could be a surrogate marker indicating need for closer supervision and follow-up by professionals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Disease in Childhood is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Health
KW - RESEARCH
KW - PUBLIC health
KW - BURNS & scalds
KW - WOUNDS & injuries
KW - GREAT Britain
N1 - Accession Number: 44328449; James-Ellison, M. 1; Email Address: michelle.james-ellison@abm-tr.wales.nhs.uk Barnes, P. 1 Maddocks, A. 2 Wareham, K. 3 Drew, P. 4 Dickson, W. 4 Lyons, R. A. 5 Hutchings, H. 5; Affiliation: 1: Department of Child Health, Abertawe Bro Morgannwg (ABM) University NHS Trust, Morriston Hospital, Swansea, UK 2: National Public Health Service, Carmarthen, UK 3: Clinical Research Unit, ABM University NHS Trust, Morriston Hospital, Swansea, UK 4: Welsh Regional Burns Unit (WRBU), ABM University NHS Trust, Morriston Hospital, Swansea, UK 5: School of Medicine, Swansea University, Swansea, UK; Source Info: Sep2009, Vol. 94 Issue 9, p663; Subject Term: CHILDREN -- Health; Subject Term: RESEARCH; Subject Term: PUBLIC health; Subject Term: BURNS & scalds; Subject Term: WOUNDS & injuries; Subject Term: GREAT Britain; Number of Pages: 5p; Illustrations: 3 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - Reuter, Gábor
AU - Boldizsár, Ákos
AU - Papp, Gábor
AU - Pankovics, Péter
T1 - Detection of Aichi virus shedding in a child with enteric and extraintestinal symptoms in Hungary.
JO - Archives of Virology
JF - Archives of Virology
Y1 - 2009/09//
VL - 154
IS - 9
M3 - Report
SP - 1529
EP - 1532
SN - 03048608
AB - Aichi virus, genus Kobuvirus, family Picornaviridae, has been proposed as a causative agent of gastroenteritis in human. Although high seroprevalence has been detected, it has been identified in only a few cases. We report detection of Aichi virus in Hungary. A total of 65 stool samples were tested retrospectively, collected from children with diarrhea, by reverse transcription-polymerase chain reaction. One (1.5%) sample from a 3-year-old girl was positive. Besides diarrhea, fever, purulent conjunctivitis and respiratory symptoms were also present at the same time with virus shedding. The genotype A virus, Kobuvirus/human/Szigetvar-HUN298/2000/Hungary (FJ225407), has 96% nucleotide identity to Aichi virus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Virology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIRUSES
KW - POLYMERASE chain reaction
KW - GENETIC research
KW - DNA polymerases
KW - GASTROINTESTINAL diseases
KW - GENETIC polymorphisms
KW - SEROPREVALENCE
N1 - Accession Number: 44190577; Reuter, Gábor 1; Email Address: reuter.gabor@ddr.antsz.hu Boldizsár, Ákos 1 Papp, Gábor Pankovics, Péter 1; Affiliation: 1: Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7, 7623 Pecs, Hungary; Source Info: Sep2009, Vol. 154 Issue 9, p1529; Subject Term: VIRUSES; Subject Term: POLYMERASE chain reaction; Subject Term: GENETIC research; Subject Term: DNA polymerases; Subject Term: GASTROINTESTINAL diseases; Subject Term: GENETIC polymorphisms; Subject Term: SEROPREVALENCE; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Illustrations: 1 Diagram; Document Type: Report
L3 - 10.1007/s00705-009-0473-y
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shu-Chen Peng
AU - Lu, Nelson
AU - Chatterjee, Monita
T1 - Effects of Cooperating and Conflicting Cues on Speech Intonation Recognition by Cochlear Implant Users and Normal Hearing Listeners.
JO - Audiology & Neuro-Otology
JF - Audiology & Neuro-Otology
Y1 - 2009/09//
VL - 14
IS - 5
M3 - Article
SP - 327
EP - 337
SN - 14203030
AB - Cochlear implant (CI) recipients have only limited access to fundamental frequency (F0) information, and thus exhibit deficits in speech intonation recognition. For speech intonation, F0 serves as the primary cue, and other potential acoustic cues (e.g. intensity properties) may also contribute. This study examined the effects of cooperating or conflicting acoustic cues on speech intonation recognition by adult CI and normal hearing (NH) listeners with full-spectrum and spectrally degraded speech stimuli. Identification of speech intonation that signifies question and statement contrasts was measured in 13 CI recipients and 4 NH listeners, using resynthesized bi-syllabic words, where F0 and intensity properties were systematically manipulated. The stimulus set was comprised of tokens whose acoustic cues (i.e. F0 contour and intensity patterns) were either cooperating or conflicting. Subjects identified if each stimulus is a ‘statement’ or a ‘question’ in a single-interval, 2-alternative forced-choice (2AFC) paradigm. Logistic models were fitted to the data, and estimated coefficients were compared under cooperating and conflicting conditions, between the subject groups (CI vs. NH), and under full-spectrum and spectrally degraded conditions for NH listeners. The results indicated that CI listeners’ intonation recognition was enhanced by cooperating F0 contour and intensity cues, but was adversely affected by these cues being conflicting. On the other hand, with full-spectrum stimuli, NH listeners’ intonation recognition was not affected by cues being cooperating or conflicting. The effects of cues being cooperating or conflicting were comparable between the CI group and NH listeners with spectrally degraded stimuli. These findings suggest the importance of taking multiple acoustic sources for speech recognition into consideration in aural rehabilitation for CI recipients. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Audiology & Neuro-Otology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COCHLEAR implants
KW - DEAFNESS
KW - DEAF
KW - SPEECH perception
KW - TONE (Phonetics)
KW - Cochlear implants
KW - Intonation
KW - Perception
KW - Speech
N1 - Accession Number: 43230588; Shu-Chen Peng 1,2; Email Address: speng@hesp.umd.edu Lu, Nelson 1 Chatterjee, Monita 2; Affiliation: 1: Center for Device and Radiological Health, US Food and Drug Administration, Rockville, Md., USA 2: Department of Hearing and Speech Sciences, Cochlear Implants and Psychophysics Laboratory, University of Maryland, College Park, Md., USA; Source Info: 2009, Vol. 14 Issue 5, p327; Subject Term: COCHLEAR implants; Subject Term: DEAFNESS; Subject Term: DEAF; Subject Term: SPEECH perception; Subject Term: TONE (Phonetics); Author-Supplied Keyword: Cochlear implants; Author-Supplied Keyword: Intonation; Author-Supplied Keyword: Perception; Author-Supplied Keyword: Speech; Number of Pages: 11p; Illustrations: 1 Diagram, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1159/000212112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43230588&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105381258
T1 - Effects of cooperating and conflicting cues on speech intonation recognition by cochlear implant users and normal hearing listeners.
AU - Peng SC
AU - Lu N
AU - Chatterjee M
AU - Peng, Shu-Chen
AU - Lu, Nelson
AU - Chatterjee, Monita
Y1 - 2009/09//
N1 - Accession Number: 105381258. Language: English. Entry Date: 20091023. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. Special Interest: Speech-Language Pathology/Audiology. Grant Information: R01 DC004786/DC/NIDCD NIH HHS/United States. NLM UID: 9606930.
KW - Cochlear Implant
KW - Hearing
KW - Phonetics
KW - Rehabilitation of Hearing Impaired
KW - Speech Perception
KW - Acoustic Stimulation
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Female
KW - Hearing Disorders -- Physiopathology
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Noise
KW - Psychometrics
KW - Speech Reception Threshold Test
KW - Human
SP - 327
EP - 337
JO - Audiology & Neuro-Otology
JF - Audiology & Neuro-Otology
JA - AUDIOL NEUROOTOL
VL - 14
IS - 5
PB - Karger AG
AB - Cochlear implant (CI) recipients have only limited access to fundamental frequency (F0) information, and thus exhibit deficits in speech intonation recognition. For speech intonation, F0 serves as the primary cue, and other potential acoustic cues (e.g. intensity properties) may also contribute. This study examined the effects of cooperating or conflicting acoustic cues on speech intonation recognition by adult CI and normal hearing (NH) listeners with full-spectrum and spectrally degraded speech stimuli. Identification of speech intonation that signifies question and statement contrasts was measured in 13 CI recipients and 4 NH listeners, using resynthesized bi-syllabic words, where F0 and intensity properties were systematically manipulated. The stimulus set was comprised of tokens whose acoustic cues (i.e. F0 contour and intensity patterns) were either cooperating or conflicting. Subjects identified if each stimulus is a 'statement' or a 'question' in a single-interval, 2-alternative forced-choice (2AFC) paradigm. Logistic models were fitted to the data, and estimated coefficients were compared under cooperating and conflicting conditions, between the subject groups (CI vs. NH), and under full-spectrum and spectrally degraded conditions for NH listeners. The results indicated that CI listeners' intonation recognition was enhanced by cooperating F0 contour and intensity cues, but was adversely affected by these cues being conflicting. On the other hand, with full-spectrum stimuli, NH listeners' intonation recognition was not affected by cues being cooperating or conflicting. The effects of cues being cooperating or conflicting were comparable between the CI group and NH listeners with spectrally degraded stimuli. These findings suggest the importance of taking multiple acoustic sources for speech recognition into consideration in aural rehabilitation for CI recipients.
SN - 1420-3030
AD - Center for Device and Radiological Health, US Food and Drug Administration, Rockville, MD, USA
AD - Center for Device and Radiological Health, US Food and Drug Administration, Rockville, MD, USA. speng@hesp.umd.edu
U2 - PMID: 19372651.
DO - 10.1159/000212112
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105381258&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - XIAODONG LUO
AU - WEI YANN TSAI
AU - QIANG XU
T1 - Pseudo-partial likelihood estimators for the Cox regression model with missing covariates.
JO - Biometrika
JF - Biometrika
Y1 - 2009/09//
VL - 96
IS - 3
M3 - Article
SP - 617
EP - 633
SN - 00063444
AB - By embedding the missing covariate data into a left-truncated and right-censored survival model, we propose a new class of weighted estimating functions for the Cox regression model with missing covariates. The resulting estimators, called the pseudo-partial likelihood estimators, are shown to be consistent and asymptotically normal. A simulation study demonstrates that, compared with the popular inverse-probability weighted estimators, the new estimators perform better when the observation probability is small and improve efficiency of estimating the missing covariate effects. Application to a practical example is reported. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Biometrika is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - REGRESSION analysis
KW - PROBABILITY theory
KW - ANALYSIS of covariance
KW - MARTINGALES (Mathematics)
KW - STOCHASTIC processes
KW - U-statistics
KW - DISTRIBUTION (Probability theory)
KW - Augmented estimator
KW - Biased sampling data
KW - Embedding missing data
KW - Left-truncation
KW - Martingale structure
KW - Right censoring
KW - U-statistic
N1 - Accession Number: 44393966; XIAODONG LUO 1; Email Address: Xiaodong.Luo@mssm.edu WEI YANN TSAI 2; Email Address: wt5@columbia.edu QIANG XU 3; Email Address: Qiang.Xu@fda.hhs.gov; Affiliation: 1: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, U.S.A. 2: Department of Biostatistics, Columbia University, New York, New York 10032, U.S.A. 3: Food and Drug Administration, Silver Spring, Maryland 20993, U.S.A.; Source Info: Sep2009, Vol. 96 Issue 3, p617; Subject Term: REGRESSION analysis; Subject Term: PROBABILITY theory; Subject Term: ANALYSIS of covariance; Subject Term: MARTINGALES (Mathematics); Subject Term: STOCHASTIC processes; Subject Term: U-statistics; Subject Term: DISTRIBUTION (Probability theory); Author-Supplied Keyword: Augmented estimator; Author-Supplied Keyword: Biased sampling data; Author-Supplied Keyword: Embedding missing data; Author-Supplied Keyword: Left-truncation; Author-Supplied Keyword: Martingale structure; Author-Supplied Keyword: Right censoring; Author-Supplied Keyword: U-statistic; Number of Pages: 17p; Illustrations: 6 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/biomet/asp027
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44393966&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Songjoon Baek
AU - Chen-An Tsai
AU - Chen, James J.
T1 - Development of biomarker classifiers from high-dimensional data.
JO - Briefings in Bioinformatics
JF - Briefings in Bioinformatics
Y1 - 2009/09//
VL - 10
IS - 5
M3 - Article
SP - 537
EP - 546
PB - Oxford University Press / USA
SN - 14675463
AB - Recent development of high-throughput technology has accelerated interest in the development of molecular biomarker classifiers for safety assessment, disease diagnostics and prognostics, and prediction of response for patient assignment. This article reviews and evaluates some important aspects and key issues in the development of biomarker classifiers. Development of a biomarker classifier for high-throughput data involves two components: (i) model building and (ii) performance assessment. This article focuses on feature selection in model building and cross validation for performance assessment. A 'frequency' approach to feature selection is presented and compared to the 'conventional' approach in terms of the predictive accuracy and stability of the selected feature set. The two approaches are compared based on four biomarker classifiers, each with a different feature selection method and well-known classification algorithm. In each of the four classifiers the feature predictor set selected by the frequency approach is more stable than the feature set selected by the conventional approach. [ABSTRACT FROM AUTHOR]
AB - Copyright of Briefings in Bioinformatics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - GENETIC markers
KW - BIOTECHNOLOGY
KW - BIOCHEMISTRY
KW - GENES
KW - DIAGNOSIS
KW - class prediction
KW - cross-validation
KW - feature selection
KW - frequency of selection
KW - stable feature set
N1 - Accession Number: 45226746; Songjoon Baek 1 Chen-An Tsai 2 Chen, James J. 3,4; Email Address: jamesj.chen@fda.hhs.gov; Affiliation: 1: Postdoctoral Fellow, National Center for Toxicological Research, U.S. Food and Drug Administration 2: Associate Professor, China Medical University, Taiwan 3: Mathematical Statistician, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration 4: Head,biostatistics program, NCTR; Source Info: Sep2009, Vol. 10 Issue 5, p537; Subject Term: BIOCHEMICAL markers; Subject Term: GENETIC markers; Subject Term: BIOTECHNOLOGY; Subject Term: BIOCHEMISTRY; Subject Term: GENES; Subject Term: DIAGNOSIS; Author-Supplied Keyword: class prediction; Author-Supplied Keyword: cross-validation; Author-Supplied Keyword: feature selection; Author-Supplied Keyword: frequency of selection; Author-Supplied Keyword: stable feature set; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 10p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1093/bib/bbp016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45226746&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Torosian, Stephen D.
AU - Regan, Patrick M.
AU - Doran, Tara
AU - Taylor, Michael A.
AU - Margolin, Aaron
T1 - A refrigeration temperature of 4 °C does not prevent static growth of Yersinia pestis in heart infusion broth.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2009/09//
VL - 55
IS - 9
M3 - Article
SP - 1119
EP - 1124
PB - Canadian Science Publishing
SN - 00084166
AB - Multiple barriers such as inspections, testing, and proper storage conditions are used to minimize the risk of contaminated food. Knowledge of which barriers, such as refrigeration, are effective in preventing pathogen growth and persistence, can help direct the focus of efforts during food sampling. In this study, the doubling times were evaluated for 10 strains of Yersinia pestis of different genetic background cultured in heart infusion broth (HIB) kept at 4 °C ± 1 °C under static conditions. Nine out of the 10 strains were able to grow at 4 °C ± 1 °C. Apparent doubling times for 7 of the strains ranged from 41 to 50 h. Strain Harbin and strain D1 had apparent doubling times of 65 and 35 h, respectively, and strain O19 Ca-6 did not grow at all. Analysis of variance showed that the averaged growth data (colony forming units per mL) between strains that grew were not significantly different. The data presented here demonstrate that refrigeration alone is not an effective barrier to prevent static growth of Y. pestis in HIB. These findings provide the preliminary impetus to investigate Y. pestis growth in a variety of food matrices that may provide a similar environment as HIB. (English) [ABSTRACT FROM AUTHOR]
AB - De multiples mesures, notamment des inspections, des tests et des conditions d’entreposage adéquates, sont utilisées pour minimiser les risques de contamination des aliments. L’identification de mesures efficaces pour prévenir la croissance et la persistance des pathogènes comme la réfrigération, peut aider à concentrer les efforts lors de prélèvements alimentaires. Dans cette étude, le temps de doublement de 10 souches de Yersinia pestis possédant des backgrounds génétiques différents, cultivées sur une gélose à l’infusion de cœur (HIB, Heart Infusion Broth) et gardées à 4 ± 1°C en conditions statiques a été évalué. Neuf des dix souches pouvaient pousser à 4 ± 1°C. Le temps de doublement apparent de sept souches s’échelonnait de 41 à 50h. La souche Harbin et la souche D1 avaient un temps de doublement apparent de 65 et 35h respectivement, et la souche O19 Ca-6 ne poussait pas du tout. Une analyse de variance (ANOVA) a montré que les données de croissance moyenne des souches qui poussaient, en termes de UFC/ml, n’étaient pas significativement différentes les unes des autres. Les données présentées ici démontrent que la réfrigération seule n’est pas une barrière efficace pour prévenir la croissance statique de Y. pestis dans le HIB. Ces résultats incitent à examiner la croissance de Y. pestis dans une variété de matrices alimentaires qui pourraient fournir un environnement similaire au HIB. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YERSINIA pestis
KW - PATHOGENIC microorganisms
KW - FOOD research
KW - INGESTION
KW - RNA
KW - foods
KW - heart infusion broth
KW - refrigeration
KW - static growth
KW - Yersinia pestis
KW - aliments
KW - croissance statique
KW - gélose à l'infusion de œeur
KW - réfrigération
N1 - Accession Number: 45234740; Torosian, Stephen D. 1 Regan, Patrick M. 1 Doran, Tara 2 Taylor, Michael A. 3 Margolin, Aaron 3; Affiliation: 1: Winchester Engineering and Analytical Center, Food and Drug Administration Winchester, MA 01890, USA 2: Massachusetts Department of Public Health, State Laboratory Institute, Jamaica Plain, MA 02130, USA 3: Department of Microbiology, University of New Hampshire, Durham, NH 03824, USA; Source Info: Sep2009, Vol. 55 Issue 9, p1119; Subject Term: YERSINIA pestis; Subject Term: PATHOGENIC microorganisms; Subject Term: FOOD research; Subject Term: INGESTION; Subject Term: RNA; Author-Supplied Keyword: foods; Author-Supplied Keyword: heart infusion broth; Author-Supplied Keyword: refrigeration; Author-Supplied Keyword: static growth; Author-Supplied Keyword: Yersinia pestis; Author-Supplied Keyword: aliments; Author-Supplied Keyword: croissance statique; Author-Supplied Keyword: gélose à l'infusion de œeur; Author-Supplied Keyword: réfrigération; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Illustrations: 1 Chart, 2 Graphs; Document Type: Article
L3 - 10.1139/W09-060
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45234740&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Torosian, Stephen D.
AU - Regan, Patrick M.
AU - Taylor, Michael A.
AU - Margolin, Aaron
T1 - Detection of Yersinia pestis over time in seeded bottled water samples by cultivation on heart infusion agar.
JO - Canadian Journal of Microbiology
JF - Canadian Journal of Microbiology
Y1 - 2009/09//
VL - 55
IS - 9
M3 - Article
SP - 1125
EP - 1129
PB - Canadian Science Publishing
SN - 00084166
AB - The viable persistence of Yersinia pestis seeded in bottled spring water was evaluated by performing 2 studies that involved inoculating a total of 21 different test strains into individual 500 mL reservoirs. Approximately 2 × 104 CFU/mL of Y. pestis was inoculated into each reservoir and held for sampling at 26 °C ± 1 °C. In study No. 2, 9 strains (Harbin, Nepal, UNH 1A, UNH 1B, ZE94, CO92, PB6, PB6 DP, and Pexu) could no longer be recovered using a plate count assay between 79 and 138 days post-seeding; other strains (K25 lcr, O19 Ca-6, and K25 pst) could no longer be recovered between 112 and 160 days post seeding. The data generated in this study demonstrate that certain strains of Y. pestis can remain viable in bottled water for extended periods of time. (English) [ABSTRACT FROM AUTHOR]
AB - La persistance de Yersinia pestis viables, ensemencées dans de l’eau de source embouteillée, a été évaluée en réalisant deux études qui impliquaient l’inoculation d’un total de vingt-et-une souches tests différentes dans des contenants de 500 mL. Approximativement 2 × 104 UFC/mL de Y. pestis ont été inoculées dans chaque contenant et gardées pour échantillonnage à 26 ± 1°C. Dans la deuxième étude, neuf souches (Harbin, Népal, UNH 1A, UNH 1B, ZE94, CO92, PB6, PB6 DP, et Pexu) n’étaient plus détectables par un essai de décompte sur plaques, de 79 à 138 jours après l’ensemencement alors que d’autres souches (K25 lcr, O19 Ca-6 et K25 pst) n’étaient plus détectables de 112 à 160 jours après l’ensemencement. Les données engendrées dans cette étude démontrent que certaines souches de Y. pestis demeurent viables dans l’eau embouteillée pendant de longues périodes de temps. (French) [ABSTRACT FROM AUTHOR]
AB - Copyright of Canadian Journal of Microbiology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YERSINIA pestis
KW - AGAR
KW - BOTTLED water
KW - BACTERIA
KW - YERSINIA pseudotuberculosis
KW - bottled water
KW - cultivation
KW - heart infusion agar
KW - Yersinia pestis
KW - eau embouteillée
KW - gélose à l'infusion de cœur
KW - persistance
N1 - Accession Number: 45234739; Torosian, Stephen D. 1 Regan, Patrick M. 1 Taylor, Michael A. 2 Margolin, Aaron 2; Affiliation: 1: Winchester Engineering and Analytical Center, Food and Drug Administration, Winchester, MA 01890, USA 2: Department of Microbiology, University of New Hampshire, Durham, NH 03824, USA; Source Info: Sep2009, Vol. 55 Issue 9, p1125; Subject Term: YERSINIA pestis; Subject Term: AGAR; Subject Term: BOTTLED water; Subject Term: BACTERIA; Subject Term: YERSINIA pseudotuberculosis; Author-Supplied Keyword: bottled water; Author-Supplied Keyword: cultivation; Author-Supplied Keyword: heart infusion agar; Author-Supplied Keyword: Yersinia pestis; Author-Supplied Keyword: eau embouteillée; Author-Supplied Keyword: gélose à l'infusion de cœur; Author-Supplied Keyword: persistance; Language of Keywords: English; Language of Keywords: French; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 312112 Bottled Water Manufacturing; NAICS/Industry Codes: 312110 Soft drink and ice manufacturing; NAICS/Industry Codes: 413210 Non-alcoholic beverage merchant wholesalers; Number of Pages: 4p; Illustrations: 1 Graph; Document Type: Article
L3 - 10.1139/W09-061
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45234739&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gray, Richard A.
AU - Wikswo, John P.
AU - Otani, Niels F.
T1 - Origin choice and petal loss in the flower garden of spiral wave tip trajectories.
JO - Chaos
JF - Chaos
Y1 - 2009/09//
VL - 19
IS - 3
M3 - Article
SP - 033118
PB - American Institute of Physics
SN - 10541500
AB - Rotating spiral waves have been observed in numerous biological and physical systems. These spiral waves can be stationary, meander, or even degenerate into multiple unstable rotating waves. The spatiotemporal behavior of spiral waves has been extensively quantified by tracking spiral wave tip trajectories. However, the precise methodology of identifying the spiral wave tip and its influence on the specific patterns of behavior remains a largely unexplored topic of research. Here we use a two-state variable FitzHugh–Nagumo model to simulate stationary and meandering spiral waves and examine the spatiotemporal representation of the system’s state variables in both the real (i.e., physical) and state spaces. We show that mapping between these two spaces provides a method to demarcate the spiral wave tip as the center of rotation of the solution to the underlying nonlinear partial differential equations. This approach leads to the simplest tip trajectories by eliminating portions resulting from the rotational component of the spiral wave. [ABSTRACT FROM AUTHOR]
AB - Copyright of Chaos is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ROTATIONAL motion
KW - FLOWER gardening
KW - DYNAMICS
KW - PARTIAL differential equations
KW - TRAJECTORIES (Mechanics)
N1 - Accession Number: 44388225; Gray, Richard A. 1,2; Email Address: richard.gray@fda.hhs.edu Wikswo, John P. 3 Otani, Niels F. 4; Affiliation: 1: Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993, USA. 2: Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. 3: Departments of Biomedical Engineering, Molecular Physiology and Biophysics, and Physics and Astronomy, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, Tennessee 37235, USA. 4: Department of Biomedical Sciences, Veterinary Research Tower, Cornell University, Ithaca, New York 14853-6401, USA.; Source Info: Sep2009, Vol. 19 Issue 3, p033118; Subject Term: ROTATIONAL motion; Subject Term: FLOWER gardening; Subject Term: DYNAMICS; Subject Term: PARTIAL differential equations; Subject Term: TRAJECTORIES (Mechanics); Number of Pages: 8p; Illustrations: 1 Diagram, 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1063/1.3204256
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44388225&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105267640
T1 - Consent of older children participating in BASCD coordinated dental epidemiology surveys in Wales.
AU - Monaghan N
AU - Morgan MZ
Y1 - 2009/09//
N1 - Accession Number: 105267640. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Dental Care; Public Health. Grant Information: National Assembly for Wales. NLM UID: 8411261.
KW - Competence (Legal) -- Psychosocial Factors
KW - Consent -- Psychosocial Factors
KW - Dental Care -- Psychosocial Factors
KW - Patient Attitudes
KW - Surveys
KW - Adolescence
KW - Adolescent Psychology
KW - Age Factors
KW - Consent -- Statistics and Numerical Data
KW - Decision Making
KW - Dental Care -- Statistics and Numerical Data
KW - Funding Source
KW - Human
KW - Readability
KW - Wales
SP - 157
EP - 161
JO - Community Dental Health
JF - Community Dental Health
JA - COMMUNITY DENT HEALTH
VL - 26
IS - 3
PB - Dennis BarberJournals
AB - New guidance on consent for England and Wales, which has positive consent at its core, has implications for the UK-wide BASCD coordinated dental epidemiology programme. This paper describes a method used in Wales for obtaining consent from older children which is believed to comply with the new guidance. OBJECTIVE: The objective was to establish a more robust approach to gaining consent from 12 and 14 year olds taking part in the surveys, by building on existing 'negative consent' practice and supplementing it with Gillick competent child consent. DESIGN AND SETTING: Questionnaire data from the 2002-03 survey of 6,393 13-14 year-old children and the 2004-05 survey of 6,749 11-12 year olds were used in this analysis. Questions specifically designed to establish competency to consent were asked of participating children. These ascertained whether children were happy to proceed and if so, whether they understood the nature and the purpose of the survey and whether they were happy with the outcome. RESULTS: Ninety-nine percent of those taking part in both survey years were happy to proceed with the examination and questionnaire. Whilst the majority of children, agreeing to take part, indicated that they had understood what was proposed and were happy with the outcome, approximately 15% of these age groups gave answers after the event which indicated that they had not understood either the nature or purpose of the survey. CONCLUSION: Use of 'Gillick competent' consent in Wales did not affect participation rates adversely. The authors would suggest that indication of assent as used in Wales in these two surveys is appropriate and would only exclude 1% of children. The alternative, of examining only those children who answered questions on whether they understood the nature and purpose of what is proposed prior to assenting, would exclude 15% of children.
SN - 0265-539X
AD - National Public Health Service, Temple of Peace, Cathays Park, Cardiff CF10 3NW, UK; Nigel.Monaghan@nphs.wales.nhs.uk
U2 - PMID: 19780356.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Taylor, Steve L.
AU - Gendel, Steven M.
AU - Houben, Geert F.
AU - Julien, Elizabeth
T1 - The Key Events Dose-Response Framework: A Foundation for Examining Variability in Elicitation Thresholds for Food Allergens.
JO - Critical Reviews in Food Science & Nutrition
JF - Critical Reviews in Food Science & Nutrition
Y1 - 2009/09//
VL - 49
IS - 8
M3 - Article
SP - 729
EP - 739
SN - 10408398
AB - Food allergies are caused by immunological reactions in individuals sensitized to normal protein components of foods. For any given sensitized individual, the severity of a reaction is generally assumed to be proportional to the dose of allergenic protein. There is substantial clinical evidence that “threshold” doses exist for the elicitation of an allergic reaction; however, the threshold (i.e., lowest dose that elicits a reaction) varies substantially across the sensitized population. Current approaches to protecting sensitized individuals from exposure to food allergens are highly qualitative (i.e., they rely on food avoidance). The Key Events Dose-Response Framework is an analytical approach for refining understanding of the biological basis of the dose-response. Application of this approach to food allergy provides a foundation for a more rigorous quantitative understanding of variability in allergic response. This study reviews the allergic disease process and the current approaches to identifying thresholds for food allergens. The pathway of key biological events occurring between food intake and allergic response is considered, along with factors that may determine the nature and severity of response to food allergens. Data needs, as well as implications for identifying thresholds, and for characterizing variability in thresholds, are also discussed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Critical Reviews in Food Science & Nutrition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD allergy
KW - FOOD -- Protein content
KW - IMMUNOLOGIC diseases
KW - INGESTION
KW - DIGESTIVE organs
KW - food allergy
KW - Key Events Dose-Response Framework
KW - Low dose dose-response
KW - minimal eliciting dose
KW - thresholds
N1 - Accession Number: 43771884; Taylor, Steve L. 1 Gendel, Steven M. 2 Houben, Geert F. 3 Julien, Elizabeth 4; Email Address: bjulien@ilsi.org; Affiliation: 1: Food Allergy Research and Resource Program, Dept. of Food Science & Technology, University of Nebraska, Lincoln, NE, USA 2: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA 3: Quality of Life, TNO, Zeist, Netherlands 4: ILSI Research Foundation, Washington, DC, USA; Source Info: Sep2009, Vol. 49 Issue 8, p729; Subject Term: FOOD allergy; Subject Term: FOOD -- Protein content; Subject Term: IMMUNOLOGIC diseases; Subject Term: INGESTION; Subject Term: DIGESTIVE organs; Author-Supplied Keyword: food allergy; Author-Supplied Keyword: Key Events Dose-Response Framework; Author-Supplied Keyword: Low dose dose-response; Author-Supplied Keyword: minimal eliciting dose; Author-Supplied Keyword: thresholds; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart; Document Type: Article
L3 - 10.1080/10408390903098707
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43771884&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siddique, Nusrat
AU - Sharma, Devang
AU - Al-Khaldi, Sufian F.
T1 - Detection of Yersinia enterocolitica in Alfalfa, Mung Bean, Cilantro, and Mamey Sapote ( Pouteria sapota) Food Matrices Using DNA Microarray Chip Hybridization.
JO - Current Microbiology
JF - Current Microbiology
Y1 - 2009/09//
VL - 59
IS - 3
M3 - Article
SP - 233
EP - 239
PB - Springer Science & Business Media B.V.
SN - 03438651
AB - Four different food matrices (alfalfa, cilantro, mamey sapote, and mung bean) were contaminated with three different dilutions 106, 104, and 103 cfu/g of Yersinia enterocolitica. DNA was isolated from each food mix and used in chromosomal amplifications. The amplified DNA was used as templates in single PCR reactions of the four genes ( virF, ail, yst, and blaA) followed by mixing the four reactions for one PCR primer extension reaction. The presence and the limit of detection of four genes in four food matrices were established by microarray hybridization. Data revealed the diversity of signal intensities. Neither the microarray chip hybridization nor the single PCR amplification could detect virF’s presence located on a plasmid. Ail was detected in 103 cfu/g, whereas blaA and yst were detected from 105 to 106 cfu/g in all food matrices. Therefore, the ail gene could be the gene of choice in identifying Y. enterocolitica in alfalfa, cilantro, mamey, and mung bean. Other genes— blaA, yst, virF—exhibited wide variability in hybridization signals, highlighting the need of a better DNA purification step prior to DNA microarray hybridization. [ABSTRACT FROM AUTHOR]
AB - Copyright of Current Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Forage plants
KW - Hybridization
KW - Breeding
KW - Yersinia enterocolitica
KW - Alfalfa
KW - DNA
N1 - Accession Number: 43596516; Siddique, Nusrat 1; Sharma, Devang 2; Al-Khaldi, Sufian F. 3; Email Address: Sufian.AlKhaldi@fda.hhs.gov; Affiliations: 1: Department of Cell Biology and Molecular Genetics, School of Life Science, University of Maryland, College Park, MD, USA.; 2: Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, MD, USA.; 3: Division of Microbiology, Office of Regulatory Science (ORS), HFS-712, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3855, USA.; Issue Info: Sep2009, Vol. 59 Issue 3, p233; Thesaurus Term: Forage plants; Thesaurus Term: Hybridization; Thesaurus Term: Breeding; Subject Term: Yersinia enterocolitica; Subject Term: Alfalfa; Subject Term: DNA; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 111940 Hay Farming; NAICS/Industry Codes: 111998 All Other Miscellaneous Crop Farming; NAICS/Industry Codes: 111999 All other miscellaneous crop farming; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; Number of Pages: 7p; Illustrations: 2 Black and White Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1007/s00284-009-9413-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43596516&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Frasch, H. Frederick
AU - Barbero, Ana M.
T1 - A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.
JO - Cutaneous & Ocular Toxicology
JF - Cutaneous & Ocular Toxicology
Y1 - 2009/09//
VL - 28
IS - 3
M3 - Article
SP - 107
EP - 113
PB - Taylor & Francis Ltd
SN - 15569527
AB - The purpose of the present study was to measure and compare permeability coefficients ( k p) and lag times ( τ) in human skin and hairless guinea pig (HGP) skin. Paired experiments employed heat-separated epidermal membranes from human and HGP sources mounted on static in vitro diffusion cells. Infinite-dose, saturated aqueous solutions of 6 industrial chemicals were used as donors: aniline, benzene, 1,2- dichloroethane, diethyl phthalate, naphthalene, and tetrachloroethylene. No significant differences were found between human and HGP skin for either k p or τ for any of these chemicals (p ≥ .24). HGP vs. human k p measurements, and HGP vs. human τ measurements, were highly correlated. For k p, the slope of the linear correlation was close to unity (1.080 ± 0.182) and the intercept close to 0 (0.015 ± 0. 029 cm/h), with a correlation coefficient ( r2) = 0.898. For τ, the slope was also close to unity (0.818 ± 0.030) and the intercept close to 0 (–0.014 ± 0.023 h), with r2 = 0.994. These results suggest that HGP skin may serve as an excellent surrogate for human skin in in vitro dermal penetration studies. [ABSTRACT FROM AUTHOR]
AB - Copyright of Cutaneous & Ocular Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Animal models in research
KW - Solution (Chemistry)
KW - Permeability
KW - Adsorption
KW - Chemicals
KW - 1
KW - 1,2-dichloroethane
KW - 2-dichloroethane
KW - aniline
KW - benzene
KW - diethyl phthalate
KW - lag time
KW - naphthalene
KW - permeability
KW - Skin absorption
KW - tetrachloroethylene
N1 - Accession Number: 43808236; Frasch, H. Frederick 1; Email Address: hfrasch@cdc.gov; Barbero, Ana M. 1; Affiliations: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Issue Info: Sep2009, Vol. 28 Issue 3, p107; Thesaurus Term: Animal models in research; Thesaurus Term: Solution (Chemistry); Thesaurus Term: Permeability; Thesaurus Term: Adsorption; Subject Term: Chemicals; Author-Supplied Keyword: 1; Author-Supplied Keyword: 1,2-dichloroethane; Author-Supplied Keyword: 2-dichloroethane; Author-Supplied Keyword: aniline; Author-Supplied Keyword: benzene; Author-Supplied Keyword: diethyl phthalate; Author-Supplied Keyword: lag time; Author-Supplied Keyword: naphthalene; Author-Supplied Keyword: permeability; Author-Supplied Keyword: Skin absorption; Author-Supplied Keyword: tetrachloroethylene; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 7p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1080/15569520902950474
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hu, Jinxin
AU - Green, Donna
AU - Swoveland, Jennifer
AU - Grant, Michael
AU - Boyle, David S.
T1 - Preliminary evaluation of a procedure for improved detection of Shiga toxin-producing Escherichia coli in fecal specimens
JO - Diagnostic Microbiology & Infectious Disease
JF - Diagnostic Microbiology & Infectious Disease
Y1 - 2009/09//
VL - 65
IS - 1
M3 - Article
SP - 21
EP - 26
SN - 07328893
AB - Abstract: Culture confirmation of Shiga toxin-producing Escherichia coli (STEC) is very important for epidemiologic analysis. However, isolation of non-O157 STEC on conventional selective media such as sorbitol–MacConkey agar (SMAC) can be difficult because of heavy growth of competing bacteria and its phenotypical similarity to commensal nonpathogenic E. coli. An acid enrichment procedure was introduced in this study to facilitate detection of STEC from patients who were symptomatic. Forty-seven clinical fecal broths, which tested positive for Shiga toxin by commercial immunoassay, were processed for the isolation of STEC by both conventional and the acid enrichment methods. The acid enrichment method and conventional culture recovered STEC from 91% (43/47) and 70% (33/47) of the fecal broths, respectively. Neither method retrieved STEC in 3 specimens. Thirty-six STEC were successfully serogrouped, which included O26 (n = 11), O157 (n = 9), O103 (n = 7), O121 (n = 3), O111 (n = 2 each), O28AC, O146, O76, and O undetermined (n = 1 each). The analysis of STEC isolates by real-time PCR indicated that all 9 E. coli O157 contained stx2 gene alone or in combination with stx1. Non-O157 STEC more frequently contained stx1 only, and about one-third possessed stx2. The novel acid enrichment protocol greatly reduced the growth of competitor colonies on RTN and TCSMAC. The study demonstrated that incorporation of an acid enrichment procedure in clinical testing improved the isolation of STEC in fecal specimens. [Copyright &y& Elsevier]
AB - Copyright of Diagnostic Microbiology & Infectious Disease is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - BACTERIAL cultures
KW - TOXINS
KW - EPIDEMIOLOGY
KW - FECES -- Examination
KW - FECAL microbiology
KW - ENZYME-linked immunosorbent assay
KW - SORBITOL
KW - TELLURITES
KW - Acid Enrichment
KW - Clinical fecal specimens
KW - Enzyme Immunoassay (EIA)
KW - Rainbow agar plus tellurite and novobiocin (RTN)
KW - Shiga-Toxin Producing E. Coli (STEC)
KW - Sorbitol MacConkey agar plus cefixime and tellurite (TCSMAC)
N1 - Accession Number: 43768163; Hu, Jinxin 1; Email Address: jinxin.hu@fda.hhs.gov Green, Donna 2 Swoveland, Jennifer 2 Grant, Michael 1 Boyle, David S. 2; Affiliation: 1: U.S. Food and Drug Administration, Bothell, WA 98021, USA 2: Washington State Department of Health, Shoreline, WA 98155, USA; Source Info: Sep2009, Vol. 65 Issue 1, p21; Subject Term: ESCHERICHIA coli; Subject Term: BACTERIAL cultures; Subject Term: TOXINS; Subject Term: EPIDEMIOLOGY; Subject Term: FECES -- Examination; Subject Term: FECAL microbiology; Subject Term: ENZYME-linked immunosorbent assay; Subject Term: SORBITOL; Subject Term: TELLURITES; Author-Supplied Keyword: Acid Enrichment; Author-Supplied Keyword: Clinical fecal specimens; Author-Supplied Keyword: Enzyme Immunoassay (EIA); Author-Supplied Keyword: Rainbow agar plus tellurite and novobiocin (RTN); Author-Supplied Keyword: Shiga-Toxin Producing E. Coli (STEC); Author-Supplied Keyword: Sorbitol MacConkey agar plus cefixime and tellurite (TCSMAC); NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.diagmicrobio.2009.05.012
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DP - EBSCOhost
DB - aph
ER -
TY -
AU - Koti, Kallappa M.1, kallappa.koti@fda.hhs.gov
T1 - Weibull Failure-Time Mixture Models for Evaluating Efficacy in the Presence of a Biomarker.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2009/09//
Y1 - 2009/09//
VL - 43
IS - 5
CP - 5
M3 - Article
SP - 585
EP - 593
SN - 00928615
AB - A predictive marker is a marker that predicts the differential efficacy of a particular therapy based on marker status. Standard statistical methods compare treatments, not validate prediction. We propose a failure-time mixture model that achieves both objectives. We also explain how to evaluate efficacy in biomarker subpopulations. We use the maximum likelihood method to estimate the mixture model. We explain the computational aspects of the model and discuss the underlying statistical inference. We discuss sample size determination. We illustrate the methodology with a computer-generated data set. The proposed mixture model is simple and capable of assisting investigators seeking to design marker-based clinical trials in their analyses. [ABSTRACT FROM AUTHOR]
KW - Computer simulation
KW - Biochemical markers
KW - Mathematical models
KW - Maximum likelihood statistics
KW - Statistics
KW - Clinical trials
KW - Biomarker development
KW - Extreme value distribution
KW - Gordon's model
KW - Likelihood ratio test
KW - Subroutine NLPTR
KW - Survival data
KW - Wald test
N1 - Accession Number: 44460726; Authors: Koti, Kallappa M. 1 Email Address: kallappa.koti@fda.hhs.gov; Affiliations: 1: US Food and Drug Administration, Silver Spring, Maryland; Subject: Biochemical markers; Subject: Mathematical models; Subject: Maximum likelihood statistics; Subject: Computer simulation; Subject: Statistics; Subject: Clinical trials; Author-Supplied Keyword: Biomarker development; Author-Supplied Keyword: Extreme value distribution; Author-Supplied Keyword: Gordon's model; Author-Supplied Keyword: Likelihood ratio test; Author-Supplied Keyword: Subroutine NLPTR; Author-Supplied Keyword: Survival data; Author-Supplied Keyword: Wald test; Number of Pages: 9p; Illustrations: 1 Chart; Record Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=44460726&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY -
AU - Dinh, Phillip1, Phillip.Dinh@fda.hhs.gov
AU - Peiling Yang1
T1 - Repeated Measures Analyses in Clinical Trials With Titration Visits.
JO - Drug Information Journal
JF - Drug Information Journal
J1 - Drug Information Journal
PY - 2009/09//
Y1 - 2009/09//
VL - 43
IS - 5
CP - 5
M3 - Article
SP - 595
EP - 602
SN - 00928615
AB - In longitudinal clinical studies, after randomization at baseline, subjects are followed for a period of time for development of symptoms. A mixed model for repeated measures (MMRM) can be used to analyze such data. To accommodate safety and tolerability, in some studies, the treatment has to be titrated to the optimal dose. Then subjects will stay on their optimal dose until the end of the study. In an MMRM analysis, one may attempt to ignore the titration visits because including them could add extra variability unnecessarily. However, when patients drop out during the titration period, ignoring the titration visits would exclude these patients from the analyses. In this article, we evaluate the impact of excluding and including titration visits in an MMRM analysis by a simulation study. We evaluate the approaches based on the bias and the coverage accuracy of the confidence interval. The results suggest that excluding titration visits may result in undercovered confidence intervals and biased estimates. [ABSTRACT FROM AUTHOR]
KW - Longitudinal method
KW - Clinical trials
KW - Dosage of drugs
KW - Mathematical models
KW - Simulation methods & models
KW - Confidence intervals
KW - Longitudinal data
KW - Missing data
KW - MMRM
KW - Titration
N1 - Accession Number: 44460727; Authors: Dinh, Phillip 1 Email Address: Phillip.Dinh@fda.hhs.gov; Peiling Yang 1; Affiliations: 1: Division of Biometrics 1, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland; Subject: Longitudinal method; Subject: Clinical trials; Subject: Dosage of drugs; Subject: Mathematical models; Subject: Simulation methods & models; Subject: Confidence intervals; Author-Supplied Keyword: Longitudinal data; Author-Supplied Keyword: Missing data; Author-Supplied Keyword: MMRM; Author-Supplied Keyword: Titration; Number of Pages: 8p; Illustrations: 6 Charts, 1 Graph; Record Type: Article
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DP - EBSCOhost
DB - lls
ER -
TY - JOUR
AU - BUGARSKI, ALEKSANDAR D.
AU - SCHNAKENBERG, JR., GEORGE H.
AU - HUMMER, JON A.
AU - CAUDA, EMANUELE
AU - JANISKO, SAMUEL J.
AU - PATTS, LARRY D.
T1 - Effects of Diesel Exhaust Aftertreatment Devices on Concentrations and Size Distribution of Aerosols in Underground Mine Air.
JO - Environmental Science & Technology
JF - Environmental Science & Technology
Y1 - 2009/09//9/1/2009
VL - 43
IS - 17
M3 - Article
SP - 6737
EP - 6743
SN - 0013936X
AB - Three types of uncatalyzed diesel particulate filter (DPF) systems, three types of high-temperature disposable filter elements (DFEs), and one diesel oxidation catalytic converter (DOC) were evaluated in underground mine conditions for their effects on the concentrations and size distributions of diesel aerosols. Those effects were compared with the effects of a standard muffler. The experimental work was conducted directly in an underground environment using a unique diesel laboratory developed in an underground experimental mine. The DPF systems reduced total mass of aerosols in the mine air approximately 10-fold for light-load and 20-fold or more for high-load test conditions. The DFEs offered similar reductions in aerosol mass concentrations. The efficiency of the new DFEs significantly increased with accumulation of operating time and buildup of diesel particulate mailer in the porous structure of the filter elements. A single laundering process did not exhibit substantial effects on performance of the filter element. The effectiveness of DPFs and DFEs in removing aerosols by number was strongly influenced by engine operating mode. The concentrations of nucleation mode aerosols in the mine air were found to be substantially higher for both DPFs and DFEa when the engine was operated at high-load modes than at low-load modes. The effects of the DOC on mass and number concentrations of aerosols in mine air were relatively minor when compared to those of the DPF and DFE systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Science & Technology is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Comparative studies
KW - Pollution control equipment
KW - Mineral industries -- Environmental aspects
KW - Air pollution -- Physiological effect
KW - Particulate matter
KW - Diesel motor exhaust gas
KW - Diesel particulate filters -- Evaluation
KW - Automobiles -- Catalytic converters
KW - Automobile engines -- Mufflers
N1 - Accession Number: 44600624; BUGARSKI, ALEKSANDAR D. 1; Email Address: abugarski@cdc.gov; SCHNAKENBERG, JR., GEORGE H. 1; HUMMER, JON A. 1; CAUDA, EMANUELE 1; JANISKO, SAMUEL J. 1; PATTS, LARRY D. 1; Affiliations: 1: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236.; Issue Info: 9/1/2009, Vol. 43 Issue 17, p6737; Thesaurus Term: RESEARCH; Thesaurus Term: Comparative studies; Thesaurus Term: Pollution control equipment; Thesaurus Term: Mineral industries -- Environmental aspects; Thesaurus Term: Air pollution -- Physiological effect; Thesaurus Term: Particulate matter; Subject Term: Diesel motor exhaust gas; Subject Term: Diesel particulate filters -- Evaluation; Subject Term: Automobiles -- Catalytic converters; Subject Term: Automobile engines -- Mufflers; NAICS/Industry Codes: 336390 Other Motor Vehicle Parts Manufacturing; NAICS/Industry Codes: 811112 Automotive Exhaust System Repair; NAICS/Industry Codes: 423120 Motor Vehicle Supplies and New Parts Merchant Wholesalers; NAICS/Industry Codes: 423520 Coal and Other Mineral and Ore Merchant Wholesalers; NAICS/Industry Codes: 418920 Mineral, ore and precious metal merchant wholesalers; NAICS/Industry Codes: 541330 Engineering Services; NAICS/Industry Codes: 423830 Industrial Machinery and Equipment Merchant Wholesalers; Number of Pages: 7p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - CRAINE, N.
AU - HICKMAN, M.
AU - PARRY, J. V.
AU - SMITH, J.
AU - WALKER, A. M.
AU - RUSSELL, D.
AU - NIX, B.
AU - MAY, M.
AU - MCDONALD, T.
AU - LYONS, M.
T1 - Incidence of hepatitis C in drug injectors: the role of homelessness, opiate substitution treatment, equipment sharing, and community size.
JO - Epidemiology & Infection
JF - Epidemiology & Infection
Y1 - 2009/09//
VL - 137
IS - 9
M3 - Article
SP - 1255
EP - 1265
SN - 09502688
AB - A prospective cohort study estimated the incidence of hepatitis C virus (HCV) in drug injectors in South Wales (UK). In total, 286/481 eligible seronegative individuals were followed up after approximately 12 months. Dried blood spot samples were collected and tested for anti-HCV antibody and behavioural data were collected at baseline and follow-up. HCV incidence was 5.9/100 person-years [95% confidence interval (CI) 3.4-9.5]. HCV incidence was predicted by community size [incident rate ratio (IRR) 6.6, 95% CI 2.11-20.51, P=0.001], homelessness (IRR 2.9, 95% CI 1.02-8.28, P=0.047) and sharing injecting equipment (IRR 12.7, 95% CI 1.62-99.6, P=0.015). HCV incidence was reduced in individuals in opiate substitution treatment (IRR 0.34, 95% CI 0.12-0.99, P=0.047). In order to reduce follow-up bias we used multiple imputation of missing data using switching regression; after imputation estimated HCV incidence was 8.5/100 person-years (95% CI 5.4-12.7). HCV incidence varies with community size, equipment sharing and homelessness are associated with increased HCV incidence and opiate substitution treatment may be protective against HCV. [ABSTRACT FROM AUTHOR]
AB - Copyright of Epidemiology & Infection is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Homeless persons
KW - Hepatitis C
KW - Liver diseases
KW - Poverty
KW - Homelessness
KW - incidence
KW - injecting drug use
KW - risk factors
N1 - Accession Number: 43630609; CRAINE, N. 1; Email Address: noel.craine@nphs.wales.nhs.uk; HICKMAN, M. 2; PARRY, J. V. 3; SMITH, J. 1; WALKER, A. M. 1; RUSSELL, D. 4; NIX, B. 5; MAY, M. 2; MCDONALD, T. 3; LYONS, M. 1; Affiliations: 1: National Public Health Service for Wales, Health Protection Team, Wales, UK.; 2: Department of Social Medicine, University of Bristol, UK.; 3: Virus Reference Department, Health Protection Agency Centre for Infections, Colindale, London, UK.; 4: NWORTH, University of Wales, Bangor, UK.; 5: Department of Epidemiology, Statistics & Public Health, Cardiff University, UK.; Issue Info: Sep2009, Vol. 137 Issue 9, p1255; Subject Term: Homeless persons; Subject Term: Hepatitis C; Subject Term: Liver diseases; Subject Term: Poverty; Subject Term: Homelessness; Author-Supplied Keyword: incidence; Author-Supplied Keyword: injecting drug use; Author-Supplied Keyword: risk factors; Number of Pages: 11p; Document Type: Article
L3 - 10.1017/S095026880900212X
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43630609&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105401417
T1 - Incidence of hepatitis C in drug injectors: the role of homelessness, opiate substitution treatment, equipment sharing, and community size.
AU - Craine N
AU - Hickman M
AU - Parry JV
AU - Smith J
AU - Walker AM
AU - Russell D
AU - Nix B
AU - May M
AU - McDonald T
AU - Lyons M
Y1 - 2009/09//
N1 - Accession Number: 105401417. Language: English. Entry Date: 20091002. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. NLM UID: 8703737.
KW - Hepatitis C, Chronic -- Epidemiology
KW - Substance Abuse, Intravenous
KW - Adult
KW - Female
KW - Homeless Persons
KW - Incidence
KW - Interviews
KW - Male
KW - Needle Sharing
KW - Population
KW - Prospective Studies
KW - Risk Factors
KW - Substance Abuse, Intravenous -- Epidemiology
KW - Substance Abuse, Intravenous -- Rehabilitation
KW - Wales
KW - Human
SP - 1255
EP - 1265
JO - Epidemiology & Infection
JF - Epidemiology & Infection
JA - EPIDEMIOL INFECT
VL - 137
IS - 9
PB - Cambridge University Press
AB - SUMMARYA prospective cohort study estimated the incidence of hepatitis C virus (HCV) in drug injectors in South Wales (UK). In total, 286/481 eligible seronegative individuals were followed up after approximately 12 months. Dried blood spot samples were collected and tested for anti-HCV antibody and behavioural data were collected at baseline and follow-up. HCV incidence was 5.9/100 person-years [95% confidence interval (CI) 3.4-9.5]. HCV incidence was predicted by community size [incident rate ratio (IRR) 6.6, 95% CI 2.11-20.51, P=0.001], homelessness (IRR 2.9, 95% CI 1.02-8.28, P=0.047) and sharing injecting equipment (IRR 12.7, 95% CI 1.62-99.6, P=0.015). HCV incidence was reduced in individuals in opiate substitution treatment (IRR 0.34, 95% CI 0.12-0.99, P=0.047). In order to reduce follow-up bias we used multiple imputation of missing data using switching regression; after imputation estimated HCV incidence was 8.5/100 person-years (95% CI 5.4-12.7). HCV incidence varies with community size, equipment sharing and homelessness are associated with increased HCV incidence and opiate substitution treatment may be protective against HCV.
SN - 0950-2688
AD - National Public Health Service for Wales, Health Protection Team, Wales, UK.
U2 - PMID: 19224654.
DO - 10.1017/S095026880900212X
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105439608
T1 - Development of sizing structure for fall arrest harness design.
AU - Hsiao H
AU - Friess M
AU - Bradtmiller B
AU - Rohlf FJ
Y1 - 2009/09//
N1 - Accession Number: 105439608. Language: English. Entry Date: 20091113. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0373220.
KW - Accidental Falls -- Prevention and Control
KW - Equipment Design
KW - Occupational Safety
KW - Biophysical Instruments
KW - Body Weights and Measures
KW - Comparative Studies
KW - Descriptive Statistics
KW - Female
KW - Forecasting
KW - Male
KW - Mathematics
KW - National Institute for Occupational Safety and Health
KW - Power Analysis
KW - Questionnaires
KW - Record Review
KW - Retrospective Design
KW - Standing
KW - Human
SP - 1128
EP - 1143
JO - Ergonomics
JF - Ergonomics
JA - ERGONOMICS
VL - 52
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Updated harness designs are needed to accommodate diverse populations in the current workforce. This paper determined an improved fall-arrest harness sizing scheme and strap-length configurations for harness design. A 3-D elliptic Fourier analysis (EFA) procedure with 123 coefficients was developed to quantify torso-shape effect on harness fit, based on 3-D data of 108 women and 108 men. The EFA coefficients were then applied to 600 representative body scans from a national database of 2382 participants to establish an improved sizing system. Study outcomes suggested a more upward back D-ring location for women than current unisex designs to accommodate female torso form and mitigate their fit problem. Results also suggested an improved system of three sizes for women and three sizes for men. New harness sizing charts for women and men were proposed accordingly. Using the most current 3-D whole-body digital scanning technology, this study assembled data from a US workforce to establish an improved fall-arrest harness sizing system and strap configurations for men and women. The information is useful for new generation harness designs to reduce the risk of worker injury.
SN - 0014-0139
AD - Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA
U2 - PMID: 19606363.
DO - 10.1080/00140130902919105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105439608&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shih-Houng Young
AU - Antonini, James M.
AU - Roberts, Jenny R.
T1 - PREEXPOSURE TO REPEATED LOW DOSES OF ZYMOSAN INCREASES THE SUSCEPTIBILITY TO PULMONARY INFECTION IN RATS.
JO - Experimental Lung Research
JF - Experimental Lung Research
Y1 - 2009/09//
VL - 35
IS - 7
M3 - Article
SP - 570
EP - 590
PB - Taylor & Francis Ltd
SN - 01902148
AB - Chronic exposure to low levels of mold has been reported to increase susceptibility to respiratory infections. In the current study, the authors investigate the lungs' ability to clear an infection after repeated low-dose zymosan exposure. Exposure was conducted at a zymosan dose of 0.6 mg/kg body weight (bw) of rat, for a total of 4 doses, via intratracheal instillation during a 2 week period. Treated animals were allowed to recover for 1 week before pulmonary inoculation with Listeria monocytogenes. Bacterial clearance was determined by measuring colony-forming units cultured from the left lungs on days 3, 5, and 7 post bacteria infection. Bronchoalveolar lavage (BAL) was performed on the right lungs to recover phagocytes and BAL fluid to measure lung injury and the inflammatory cytokines. In contrast to the authors' previously published study that showed a single high dose (2.5 mg/kg bw) of zymosan prior to infection accelerated bacteria clearance, the repeated low-dose zymosan suppressed bacteria clearance from the lungs early after infection and induced higher lung injury and inflammation compared to control. The innate immune response was down-regulated and a Th2 immune response was preferentially induced rather than a Th1 response, the latter being more effective toward the resolution of a L. monocytogenes infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Experimental Lung Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ZYMOSAN
KW - RESPIRATORY infections
KW - LISTERIA monocytogenes
KW - BRONCHOALVEOLAR lavage
KW - INFLAMMATION
KW - LUNGS -- Wounds & injuries
KW - 1 →3-β-glucans
KW - 1→3-β-glucans
KW - fungal infections
KW - Listeria monocytogenes
KW - lung inflammation
KW - pulmonary clearance
N1 - Accession Number: 44192652; Shih-Houng Young 1; Email Address: sby5@cdc.gov Antonini, James M. 1 Roberts, Jenny R. 1; Affiliation: 1: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Source Info: Sep2009, Vol. 35 Issue 7, p570; Subject Term: ZYMOSAN; Subject Term: RESPIRATORY infections; Subject Term: LISTERIA monocytogenes; Subject Term: BRONCHOALVEOLAR lavage; Subject Term: INFLAMMATION; Subject Term: LUNGS -- Wounds & injuries; Author-Supplied Keyword: 1 →3-β-glucans; Author-Supplied Keyword: 1→3-β-glucans; Author-Supplied Keyword: fungal infections; Author-Supplied Keyword: Listeria monocytogenes; Author-Supplied Keyword: lung inflammation; Author-Supplied Keyword: pulmonary clearance; Number of Pages: 21p; Illustrations: 1 Diagram, 2 Charts, 6 Graphs; Document Type: Article
L3 - 10.1080/01902140902763201
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44192652&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Meldrum, R.J.
AU - Little, C.L.
AU - Sagoo, S.
AU - Mithani, V.
AU - McLauchlin, J.
AU - de Pinna, E.
T1 - Assessment of the microbiological safety of salad vegetables and sauces from kebab take-away restaurants in the United Kingdom
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009/09//
VL - 26
IS - 6
M3 - Article
SP - 573
EP - 577
SN - 07400020
AB - Abstract: The purpose of this study was to establish the microbiological safety of salad vegetables and sauces served in kebab take-away restaurants. Comparison with published microbiological guidelines revealed that 4.7% of 1213 salad vegetable samples were of unsatisfactory microbiological quality due to Escherichia coli and/or Staphylococcus aureus levels at ≥102 cfu g−1. Another 0.3% of salad samples were of unacceptable quality due to S. aureus at ≥104 cfu g−1 (2 samples) or the presence of Salmonella Kentucky (1 sample). Cucumber was the most contaminated salad vegetable with regards to unsatisfactory levels of E. coli (6.0%) or S. aureus (4.5%). Five percent of 1208 sauce samples were of unsatisfactory microbiological quality due to E. coli, S. aureus at ≥102 cfu g−1 and/or Bacillus cereus and other Bacillus spp. at ≥104 cfu g−1. A further 0.6% of sauce samples were of unacceptable quality due to Bacillus spp. (Bacillus subtilis, Bacillus pumilus, Bacillus licheniformis) at ≥105 cfu g−1 or the presence of Salmonella Agbeni (1 sample). More samples of chilli sauce (8.7%) were of unsatisfactory or unacceptable microbiological quality than any other sauce types. The results emphasize the need for good hygiene practices in kebab take-away restaurants handling these types of ready-to-eat products. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ENTEROBACTERIACEAE
KW - FOODBORNE diseases
KW - ESCHERICHIA coli
KW - HORTICULTURAL crops
KW - Bacillus cereus
KW - Escherichia coli
KW - Salad vegetables
KW - Salmonella
KW - Sauces
KW - Staphylococcus aureus
N1 - Accession Number: 41588407; Meldrum, R.J. 1 Little, C.L. 2; Email Address: christine.little@hpa.org.uk Sagoo, S. 2 Mithani, V. 2 McLauchlin, J. 3 de Pinna, E. 2; Affiliation: 1: National Public Health Service for Wales, Microbiology Laboratory, Llandough Hospital, Penarth, Vale of Glamorgan, CF64 2XX, UK 2: Department of Gastrointestinal Emerging and Zoonotic Infections, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK 3: Health Protection Agency Regional Microbiology Network, London WC1V 7PP, UK; Source Info: Sep2009, Vol. 26 Issue 6, p573; Subject Term: ENTEROBACTERIACEAE; Subject Term: FOODBORNE diseases; Subject Term: ESCHERICHIA coli; Subject Term: HORTICULTURAL crops; Author-Supplied Keyword: Bacillus cereus; Author-Supplied Keyword: Escherichia coli; Author-Supplied Keyword: Salad vegetables; Author-Supplied Keyword: Salmonella; Author-Supplied Keyword: Sauces; Author-Supplied Keyword: Staphylococcus aureus; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.fm.2009.03.013
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41588407&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Pandit, Shatakshi
AU - Paul, Sudakshina
AU - Li Zhang
AU - Min Chen
AU - Durbin, Nicole
AU - Harrison, Susan M. W.
AU - Rymond, Brian C.
T1 - Spp382p Interacts with Multiple Yeast Splicing Factors, Including Possible Regulators of Prp43 DExD/H-Box Protein Function.
JO - Genetics
JF - Genetics
Y1 - 2009/09//
VL - 183
IS - 1
M3 - Article
SP - 195
EP - 206
SN - 00166731
AB - Prp43p catalyzes essential steps in pre-mRNA splicing and rRNA biogenesis. In splicing, Spp382p stimulates the Prp43p helicase to dissociate the postcatalytic spliceosome and, in some way, to maintain the integrity of the spliceosome assembly. Here we present a dosage interference assay to identify Spp382p- interacting factors by screening for genes that when overexpressed specifically inhibit the growth of a conditional lethal prp38-1 spliceosome assembly mutant in the spp382-1 suppressor background. Identified, among others, are genes encoding the established splicing factors Prp8p, Prp9p, Prpilp, Prp39p, and Yhclp and two poorly characterized proteins with possible links to splicing, Sqslp and Cwc23p. Sqs~p copurifies with Prp43p and is shown to bind Prp43p and Spp382p in the two-hybrid assay. Overexpiession of Sqsl p blocks pre-mRNA splicing and inhibits Prp43p-clependent steps in rRNA processing. Increased Prp43p levels buffer Sqslp cytotoxicity, providing strong evidence that the Prp43p DExD/H-box protein is a target of Sqslp. Cwc23p is the only known yeast splicing factor with a Dn~j motif characteristic of Hsp4O- like chaperones. We show that similar to SPP382, CWC23 activity is critical for efficient pre-mRNA splicing and intron metabolism yet, surprisingly, this activity does not require the canonical DnaJ/Hsp4O motif. These and related data establish the value of this dosage interference assay for finding genes that alter cellular splicing and define Sqsl p and Cwc23p as prospective modulators of Spp382p-stimuated Prp43p function. [ABSTRACT FROM AUTHOR]
AB - Copyright of Genetics is the property of Genetics Society of America and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RNA splicing
KW - GENETIC regulation
KW - GENE expression
KW - MESSENGER RNA
KW - CELL-mediated cytotoxicity
KW - GENETIC research
N1 - Accession Number: 44948153; Pandit, Shatakshi 1,2 Paul, Sudakshina 1 Li Zhang 1,3 Min Chen 1 Durbin, Nicole 1 Harrison, Susan M. W. 1 Rymond, Brian C. 1; Email Address: rymond@uky.edu; Affiliation: 1: Department of Biology, University of Kentucky, Lexington, Kentucky 40506-0225 2: Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 3: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740-3835; Source Info: Sep2009, Vol. 183 Issue 1, p195; Subject Term: RNA splicing; Subject Term: GENETIC regulation; Subject Term: GENE expression; Subject Term: MESSENGER RNA; Subject Term: CELL-mediated cytotoxicity; Subject Term: GENETIC research; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 12p; Document Type: Article
L3 - 10.1534/genetics.109.106955
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44948153&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105433839
T1 - Combating fraud in health care: an essential component of any cost containment strategy.
AU - Morris L
Y1 - 2009/09//Sep/Oct2009
N1 - Accession Number: 105433839. Language: English. Entry Date: 20091016. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; Peer Reviewed; USA. NLM UID: 8303128.
KW - Cost Savings
KW - Fraud -- Prevention and Control
KW - Health Services
KW - Audit
KW - Billing and Claims -- Methods
KW - Collaboration
KW - Contract Services -- Methods
KW - Data Mining
KW - Government Agencies
KW - Guideline Adherence
KW - Health Care Reform
KW - Medicaid
KW - Medicare
KW - Physician's Role
KW - Police
KW - Reaction Time
KW - Vendor Relations
SP - 1351
EP - 1356
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
IS - 5
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - Federal health care programs, including Medicare and Medicaid, are under attack by dishonest people who lie to the government and exploit its programs to steal taxpayers' money. The full extent of health care fraud cannot be measured precisely. However, the Federal Bureau of Investigation (FBI) estimates that fraudulent billings to public and private health care programs are 3-10 percent of total health spending, or $75-$250 billion in fiscal year 2009. Successful efforts to stop such abuses, without unduly burdening legitimate providers, require aggressive, innovative, and sustained attention to protect taxpayers and beneficiaries.
SN - 0278-2715
AD - Office of Inspector General, US Department of Health and Human Services (HHS), Washington, DC, USA. Lewis.Morris@oig.hhs.gov
U2 - PMID: 19738251.
DO - 10.1377/hlthaff.28.5.1351
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Sammarco, John J.
AU - Freyssinier, Jean Paul
AU - Bullough, John D.
AU - Xin Zhang
AU - Reyes, Miguel A.
T1 - Technological Aspects of Solid-State and Incandescent Sources for Miner Cap Lamps.
JO - IEEE Transactions on Industry Applications
JF - IEEE Transactions on Industry Applications
Y1 - 2009/09//Sep/Oct2009
VL - 45
IS - 5
M3 - Article
SP - 1583
EP - 1588
SN - 00939994
AB - Light-emitting diodes (LEDs) are emerging as viable replacements for incandescent (INC)-based cap lamps used in mining. The photometric and energy characteristics of these light sources differ in important ways. This paper describes the performance of LED and INC sources in cap lamps in terms of correlated color temperature, color rendering, light output, electric power, ambient temperature and air flow, and light source aging. Importantly, these characteristics can influence a miner's ability to spot mining hazards thus impacting safety. Second, some of these characteristics interact with the operating life of the cap lamp's battery power, such that differences between LED and INC sources can be magnified toward the end of a 10-h battery discharge cycle. Empirically, we have determined that after 8 h at an ambient temperature of 25 °C, the average light output of an INC cap lamp can decrease to about 69% of its initial value when powered by a lead-acid battery, and it can decrease to about 65% of its initial value when powered by a nickel-hydride battery. An LED-based cap lamp using a constant current drive circuit can maintain about 96% of its initial value when powered by a nickel-hydride battery. Real-world tests addressing the effects of ambient temperature and air flow on the light output of an LED and INC cap lamp were conducted in the National Institute for Occupational Safety and Health Safety Research Coal Mine. The LED cap lamp yielded a vertical average illuminance improvement of approximately 9.5%, and the INC cap lamp yielded a vertical average illuminance degradation of approximately 4%. The differences between LED and INC cap lamps were further quantified by the calculation of "mesopic luminance" data that indicated for the same photopic luminance (i.e., as measured using a conventional light meter) the LED cap lamp could be up to 38% more efficient than the INC cap lamp with a lead-acid battery at the end of the 10-h driving cycle. Lastly, accelerated life tests were used to empirically determine light output depreciation as the INC light source age approached its useful life. There was about a 35% decrease in light output. This is quite considerable, particularly given that the light output will decrease an additional 30% to 45% over the period of a 10-h shift. The implications of the differences between LED and INC sources are discussed. This information is crucial in determining how visual performance could be affected for real-world conditions where batteries discharge during the work shift and as the light source ages. To date, only idealized conditions have been used for LED and INC cap lamp visual performance research. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Industry Applications is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIGHT sources
KW - LIGHT emitting diodes
KW - INCANDESCENT lamps
KW - MINE safety
KW - VISUAL perception
KW - INDUSTRIAL safety
KW - Cap lamps
KW - mine illumination
KW - mine safety
KW - visual performance
N1 - Accession Number: 44466096; Sammarco, John J. 1; Email Address: jsammarco@cdc.gov Freyssinier, Jean Paul 2 Bullough, John D. 2 Xin Zhang 2 Reyes, Miguel A. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA 15236 USA 2: Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY 12180 USA; Source Info: Sep/Oct2009, Vol. 45 Issue 5, p1583; Subject Term: LIGHT sources; Subject Term: LIGHT emitting diodes; Subject Term: INCANDESCENT lamps; Subject Term: MINE safety; Subject Term: VISUAL perception; Subject Term: INDUSTRIAL safety; Author-Supplied Keyword: Cap lamps; Author-Supplied Keyword: mine illumination; Author-Supplied Keyword: mine safety; Author-Supplied Keyword: visual performance; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 541330 Engineering Services; Number of Pages: 6p; Document Type: Article
L3 - 10.1109/TIA.2009.2027398
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sandbulte, Matthew R.
AU - Jin Gao
AU - Straight, Timothy M.
AU - Eichelberger, Maryna C.
T1 - A miniaturized assay for influenza neuraminidase-inhibiting antibodies utilizing reverse genetics-derived antigens.
JO - Influenza & Other Respiratory Viruses
JF - Influenza & Other Respiratory Viruses
Y1 - 2009/09//
VL - 3
IS - 5
M3 - Article
SP - 233
EP - 240
SN - 17502640
AB - Background Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sialic acid following incubation of NA with substrate in the presence of serum. In addition, the assay is complicated by the need to use virus of a hemagglutinin (HA) subtype novel to the host to detect NA-specific antibodies only. Objectives Our primary objectives were to miniaturize the colorimetric NI assay to a format suitable for quantitative analysis of large numbers of samples, and validate the specificity and sensitivity of the miniaturized format with ferret and human sera. An additional aim was to use reverse genetics to construct HA-mismatched viral reagents bearing NA of recent influenza A vaccine strains and H6 HA. Results Analysis of ferret antisera by the miniaturized assay demonstrated sensitivity and specificity comparable with the conventional assay. Similar increases in the NI titers in sera from vaccinated human volunteers were measured in miniaturized and conventional assays. Inactivated and live-attenuated vaccines increased NI titers against a given subtype at approximately the same rate. Conclusions The reagents and miniaturized format of the TBA method described here provide a platform for practical serological monitoring of functional antibodies against NA. [ABSTRACT FROM AUTHOR]
AB - Copyright of Influenza & Other Respiratory Viruses is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEURAMINIDASE
KW - IMMUNOGLOBULINS
KW - INFLUENZA viruses
KW - RESPIRATORY infections
KW - GENETICS
KW - Influenza virus
KW - miniaturized assay
KW - neuraminidase
KW - reverse genetics
N1 - Accession Number: 43751464; Sandbulte, Matthew R. 1; Email Address: matthew.sandbulte@fda.hhs.gov Jin Gao 1 Straight, Timothy M. 2 Eichelberger, Maryna C. 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA 2: Brooke Army Medical Center, Fort Sam Houston, TX, USA; Source Info: Sep2009, Vol. 3 Issue 5, p233; Subject Term: NEURAMINIDASE; Subject Term: IMMUNOGLOBULINS; Subject Term: INFLUENZA viruses; Subject Term: RESPIRATORY infections; Subject Term: GENETICS; Author-Supplied Keyword: Influenza virus; Author-Supplied Keyword: miniaturized assay; Author-Supplied Keyword: neuraminidase; Author-Supplied Keyword: reverse genetics; Number of Pages: 8p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1750-2659.2009.00094.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43751464&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C. Özgen
T1 - Forecasting gob gas venthole production performances using intelligent computing methods for optimum methane control in longwall coal mines
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2009/09//
VL - 79
IS - 4
M3 - Article
SP - 131
EP - 144
SN - 01665162
AB - Abstract: Gob gas ventholes (GGV) are used to control methane inflows into a longwall operation by capturing it within the overlying fractured strata before it enters the work environment. Thus, it is important to understand the effects of various factors, such as drilling parameters, location of borehole, applied vacuum by exhausters and mining/panel parameters in order to be able to evaluate the performance of GGVs and to predict their effectiveness in controlling methane emissions. However, a practical model for this purpose currently does not exist. In this paper, we analyzed the total gas flow rates and methane percentages from 10 GGVs located on three adjacent panels operated in Pittsburgh coalbed in Southwestern Pennsylvania section of Northern Appalachian basin. The ventholes were drilled from different surface elevations and were located at varying distances from the start-up ends of the panels and from the tailgate entries. Exhauster pressures, casing diameters, location of longwall face and mining rates and production data were also recorded. These data were incorporated into a multilayer-perceptron (MLP) type artificial neural network (ANN) to model venthole production. The results showed that the two-hidden layer model predicted total production and the methane content of the GGVs with more than 90% accuracy. The ANN model was further used to conduct sensitivity analyses about the mean of the input variables to determine the effect of each input variable on the predicted production performance of GGVs. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COAL mines & mining
KW - LONGWALL mining
KW - BOREHOLE mining
KW - GAS flow
KW - METHANE
KW - PERFORMANCE evaluation
KW - PITTSBURGH (Pa.)
KW - PENNSYLVANIA
KW - Artificial neural networks
KW - Gob gas ventholes
KW - Longwall mining
KW - Methane control
KW - Production performance
KW - Sensitivity analysis
N1 - Accession Number: 43766108; Karacan, C. Özgen 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, Pittsburgh, PA 15236, USA; Source Info: Sep2009, Vol. 79 Issue 4, p131; Subject Term: COAL mines & mining; Subject Term: LONGWALL mining; Subject Term: BOREHOLE mining; Subject Term: GAS flow; Subject Term: METHANE; Subject Term: PERFORMANCE evaluation; Subject Term: PITTSBURGH (Pa.); Subject Term: PENNSYLVANIA; Author-Supplied Keyword: Artificial neural networks; Author-Supplied Keyword: Gob gas ventholes; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Methane control; Author-Supplied Keyword: Production performance; Author-Supplied Keyword: Sensitivity analysis; NAICS/Industry Codes: 213117 Contract drilling (except oil and gas); NAICS/Industry Codes: 213113 Support Activities for Coal Mining; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.coal.2009.07.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43766108&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gallagher, Sean
AU - Kotowski, Susan
AU - Davis, Kermit G.
AU - Mark, Christopher
AU - Compton, Craig S.
AU - Huston, Ronald L.
AU - Connelly, John
T1 - External L5–S1 joint moments when lifting wire mesh screen used to prevent rock falls in underground mines
JO - International Journal of Industrial Ergonomics
JF - International Journal of Industrial Ergonomics
Y1 - 2009/09//
VL - 39
IS - 5
M3 - Article
SP - 828
EP - 834
SN - 01698141
AB - Abstract: Bolting large sheets of wire mesh screen (WMS) to the roof of underground mines prevents injuries due to rock falls. However, WMS can be heavy and awkward to lift and transport, and may result in significant spinal loading. Accordingly, six male subjects (mean age=45.8 years+7.5 SD) were recruited to lift WMS in a laboratory investigation of the biomechanical demands. Biomechanical modeling was used to estimate external moments about L5–S1 for sixteen lifting tasks, using two sizes of WMS. Full-size WMS involved a two-person lift, while half-size WMS involved a one-person lift. Lifts were performed under 168cm and 213cm vertical space. Restriction in vertical space increased the maximum L5–S1 extensor moment from 254 to 274Nm and right lateral bending moment from 195 to 251Nm. Lifting full sheets of screen (as opposed to half sheets) resulted in an average 33Nm increase in L5–S1 extensor moment. The L5–S1 extensor moment was increased by an average of 44Nm (18%) when lifting screens positioned flat on the floor compared to an upright position. Relevance to industry: Large flexible materials are commonly lifted in industrial work environments, and may involve the efforts of two or more workers. The current study examines the low back loading associated with lifting large flexible screens and presents recommendations to reduce spine loading. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Industrial Ergonomics is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Industrial safety
KW - Biomechanics
KW - Mine roof bolting
KW - Mine accidents
KW - Wire netting
KW - Human experimentation
KW - Estimates
KW - Lifting & carrying (Human mechanics)
KW - Loads (Mechanics)
KW - Work environment
KW - Biomechanical modeling
KW - Low back disorders
KW - Manual materials handling
KW - Restricted workspace
KW - Underground mining
KW - Wire mesh screen
N1 - Accession Number: 43765893; Gallagher, Sean 1; Email Address: sfg9@cdc.gov; Kotowski, Susan 2; Davis, Kermit G. 2; Mark, Christopher 1; Compton, Craig S. 1; Huston, Ronald L. 2; Connelly, John 2; Affiliations: 1: National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA; 2: University of Cincinnati, 2600 Clifton Ave., Cincinnati, OH 45221, USA; Issue Info: Sep2009, Vol. 39 Issue 5, p828; Thesaurus Term: Industrial safety; Thesaurus Term: Biomechanics; Subject Term: Mine roof bolting; Subject Term: Mine accidents; Subject Term: Wire netting; Subject Term: Human experimentation; Subject Term: Estimates; Subject Term: Lifting & carrying (Human mechanics); Subject Term: Loads (Mechanics); Subject Term: Work environment; Author-Supplied Keyword: Biomechanical modeling; Author-Supplied Keyword: Low back disorders; Author-Supplied Keyword: Manual materials handling; Author-Supplied Keyword: Restricted workspace; Author-Supplied Keyword: Underground mining; Author-Supplied Keyword: Wire mesh screen; NAICS/Industry Codes: 331318 Other Aluminum Rolling, Drawing, and Extruding; NAICS/Industry Codes: 332619 Other fabricated wire product manufacturing; NAICS/Industry Codes: 332618 Other Fabricated Wire Product Manufacturing; NAICS/Industry Codes: 331491 Nonferrous Metal (except Copper and Aluminum) Rolling, Drawing, and Extruding; NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 331222 Steel Wire Drawing; NAICS/Industry Codes: 331420 Copper Rolling, Drawing, Extruding, and Alloying; NAICS/Industry Codes: 331490 Non-ferrous metal (except copper and aluminum) rolling, drawing, extruding and alloying; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.ergon.2009.01.005
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105323826
T1 - Competing commitments in clinical trials.
AU - Lidz CW
AU - Appelbaum PS
AU - Joffe S
AU - Albert K
AU - Rosenbaum J
AU - Simon L
Y1 - 2009/09//
N1 - Accession Number: 105323826. Language: English. Entry Date: 20091120. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: National Institute of Neurological Disorders and Stroke. NLM UID: 7906878.
KW - Attitude of Health Personnel
KW - Clinical Trials -- Ethical Issues
KW - Commitment -- Ethical Issues
KW - Conflict of Interest -- Ethical Issues
KW - Analysis of Variance
KW - Chi Square Test
KW - Data Analysis Software
KW - Female
KW - Funding Source
KW - Internet
KW - Interviews
KW - Male
KW - Random Sample
KW - Research Subject Recruitment
KW - Sample Size
KW - Surveys
KW - Human
SP - 1
EP - 6
JO - IRB: Ethics & Human Research
JF - IRB: Ethics & Human Research
JA - IRB ETHICS HUM RES
VL - 31
IS - 5
CY - Garrison, New York
PB - Hastings Center
SN - 0193-7758
AD - Research Professor of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105323826&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zou, W.
AU - Frye, J. G.
AU - Chang, C.-W.
AU - Liu, J.
AU - Cerniglia, C. E.
AU - Nayak, R.
T1 - Microarray analysis of antimicrobial resistance genes in Salmonella enterica from preharvest poultry environment.
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
Y1 - 2009/09//
VL - 107
IS - 3
M3 - Article
SP - 906
EP - 914
PB - Wiley-Blackwell
SN - 13645072
AB - Aims: To detect antimicrobial resistance genes in Salmonella isolates from turkey flocks using the microarray technology. Methods and Results: A 775 gene probe oligonucleotide microarray was used to detect antimicrobial resistance genes in 34 isolates. All tetracycline-resistant Salmonella harboured tet(A), tet(C) or tet(R), with the exception of one Salmonella serotype Heidelberg isolate. The sul1 gene was detected in 11 of 16 sulfisoxazole-resistant isolates. The aadA, aadA1, aadA2, strA or strB genes were found in aminoglycoside-resistant isolates of Salm. Heidelberg, Salmonella serotype Senftenberg and untypeable Salmonella. The prevalence of mobile genetic elements, such as class I integron and transposon genes, in drug-resistant Salmonella isolates suggested that these elements may contribute to the dissemination of antimicrobial resistance genes in the preharvest poultry environment. Hierarchical clustering analysis demonstrated a close relationship between drug-resistant phenotypes and the corresponding antimicrobial resistance gene profiles. Conclusions: Salmonella serotypes isolated from the poultry environment carry multiple genes that can render them resistant to several antimicrobials used in poultry and humans. Significance and Impact of the Study: Multiple antimicrobial resistance genes in environmental Salmonella isolates could be identified efficiently by microarray analysis. Hierarchical clustering analysis of the data was also found to be a useful tool for analysing emerging patterns of drug resistance. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Applied Microbiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Salmonella
KW - Food pathogens
KW - Enterobacteriaceae
KW - Genotype-environment interaction
KW - Anti-infective agents
KW - Poultry diseases
KW - Drug resistance
KW - antimicrobial resistance genes
KW - hierarchical analysis
KW - microarray
KW - poultry
KW - turkey
N1 - Accession Number: 43609203; Zou, W. 1; Frye, J. G. 2; Chang, C.-W. 3; Liu, J. 4; Cerniglia, C. E. 1; Nayak, R. 1; Email Address: Rajesh.Nayak@fda.hhs.gov; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 2: Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Agricultural Research Service, US Department of Agriculture, Athens, GA, USA; 3: Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 4: Department of Genetics, Washington University School of Medicine in St Louis, St Louis, MO, USA; Issue Info: Sep2009, Vol. 107 Issue 3, p906; Thesaurus Term: Salmonella; Thesaurus Term: Food pathogens; Thesaurus Term: Enterobacteriaceae; Thesaurus Term: Genotype-environment interaction; Thesaurus Term: Anti-infective agents; Subject Term: Poultry diseases; Subject Term: Drug resistance; Author-Supplied Keyword: antimicrobial resistance genes; Author-Supplied Keyword: hierarchical analysis; Author-Supplied Keyword: microarray; Author-Supplied Keyword: poultry; Author-Supplied Keyword: turkey; NAICS/Industry Codes: 424440 Poultry and Poultry Product Merchant Wholesalers; NAICS/Industry Codes: 413130 Poultry and egg merchant wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 112390 Other Poultry Production; NAICS/Industry Codes: 445210 Meat Markets; Number of Pages: 9p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1111/j.1365-2672.2009.04270.x
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Springman, A. Cody
AU - Lacher, David W.
AU - Guangxi Wu
AU - Milton, Nicole
AU - Whittam, Thomas S.
AU - Davies, H. Dele
AU - Manning, Shannon D.
T1 - Selection, Recombination, and Virulence Gene Diversity among Group B Streptococcal Genotypes.
JO - Journal of Bacteriology
JF - Journal of Bacteriology
Y1 - 2009/09//
VL - 191
IS - 17
M3 - Article
SP - 5419
EP - 5427
SN - 00219193
AB - Transmission of group B Streptococcus (GBS) from mothers to neonates during childbirth is a leading cause of neonatal sepsis and meningitis. Although subtyping tools have identified specific GBS phylogenetic lineages that are important in neonatal disease, little is known about the genetic diversity of these lineages or the roles that recombination and selection play in the generation of emergent genotypes. Here, we examined genetic variation, selection, and recombination in seven multilocus sequence typing (MLST) loci from 94 invasive, colonizing, and bovine strains representing 38 GBS sequence types and performed DNA sequencing and PCR-based restriction fragment length polymorphism analysis of several putative virulence genes to identify gene content differences between genotypes. Despite the low level of diversity in the MLST loci, a neighbor net analysis revealed a variable range of genetic exchange among the seven clonal complexes (CCs) identified, suggesting that recombination is partly responsible for the diversity observed between genotypes. Recombination is also important for several virulence genes, as some gene alleles had evidence for lateral gene exchange across divergent genotypes. The CC-17 lineage, which is associated with neonatal disease, is relatively homogeneous and therefore appears to have diverged independently with an exclusive set of virulence characteristics. These data suggest that different GBS genetic backgrounds have distinct virulence gene profiles that may be important for disease pathogenesis. Such profiles could be used as markers for the rapid detection of strains with an increased propensity to cause neonatal disease and may be considered useful vaccine targets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Bacteriology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SEPTICEMIA
KW - STREPTOCOCCUS
KW - HUMAN genetics -- Variation
KW - GENETIC polymorphisms
KW - GENETIC recombination
KW - MENINGITIS
KW - BIOCHEMISTRY
KW - NEONATOLOGY
N1 - Accession Number: 44046966; Springman, A. Cody 1,2 Lacher, David W. 1,3 Guangxi Wu 1,2 Milton, Nicole 1,2 Whittam, Thomas S. 1 Davies, H. Dele 2 Manning, Shannon D. 1,2; Email Address: Shannon.Manning@ht.msu.edu; Affiliation: 1: Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 488242 2: Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 488242 3: U.S. Food and Drug Administration, Division of Molecular Biology, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, MD 20708; Source Info: Sep2009, Vol. 191 Issue 17, p5419; Subject Term: SEPTICEMIA; Subject Term: STREPTOCOCCUS; Subject Term: HUMAN genetics -- Variation; Subject Term: GENETIC polymorphisms; Subject Term: GENETIC recombination; Subject Term: MENINGITIS; Subject Term: BIOCHEMISTRY; Subject Term: NEONATOLOGY; Number of Pages: 9p; Document Type: Article
L3 - 10.1128/JB.00369-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44046966&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Siddiqui, Ohidul
T1 - Statistical Methods to Analyze Adverse Events Data of Randomized Clinical Trials.
JO - Journal of Biopharmaceutical Statistics
JF - Journal of Biopharmaceutical Statistics
Y1 - 2009/09//Sep/Oct2009
VL - 19
IS - 5
M3 - Article
SP - 889
EP - 899
PB - Taylor & Francis Ltd
SN - 10543406
AB - The adverse events data of randomized clinical trials are often analyzed based on either crude incidence rates or exposure-adjusted incidence rates. These rates do not adequately account for an individual patient's profile of adverse events over the study period when an individual may remain in the trial after experiencing one or more events (i.e., occurrence of multiple events of the same kind or different kinds). Moreover, the required statistical assumptions (e.g., constant hazard rate over time) for valid estimates of incidence rates are not likely to be met in practice by adverse events data of clinical trials. A nonparametric approach called the mean cumulative function (MCF) provides a valid statistical inference on recurrent adverse event profiles of drugs in randomized clinical trials. The estimate involves no assumptions about the form of MCF. To demonstrate the applicability and utility of the MCF approach in clinical trial datasets, an adverse event dataset obtained from a clinical trial is analyzed in this article. As compared to the crude or exposure-adjusted incidence rates of adverse events, the MCF estimates facilitate more understanding of safety profiles of a drug in a randomized clinical trial. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biopharmaceutical Statistics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL trials
KW - CLINICAL drug trials
KW - ASTEMIZOLE
KW - ANTIHISTAMINES
KW - PATIENTS
KW - STATISTICS
KW - Adverse events
KW - AEs
KW - Gender
KW - ISS
KW - MCF
N1 - Accession Number: 43607576; Siddiqui, Ohidul 1; Email Address: ohidul.siddiqui@fda.hhs.gov; Affiliation: 1: Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA; Source Info: Sep/Oct2009, Vol. 19 Issue 5, p889; Subject Term: CLINICAL trials; Subject Term: CLINICAL drug trials; Subject Term: ASTEMIZOLE; Subject Term: ANTIHISTAMINES; Subject Term: PATIENTS; Subject Term: STATISTICS; Author-Supplied Keyword: Adverse events; Author-Supplied Keyword: AEs; Author-Supplied Keyword: Gender; Author-Supplied Keyword: ISS; Author-Supplied Keyword: MCF; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 11p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1080/10543400903105463
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43607576&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wang, Diane D.
AU - Shuzhong Zhang
AU - Hong Zhao
AU - Men, Angela Y.
AU - Parivar, Kourosh
T1 - Fixed Dosing Versus Body Size-Based Dosing of Monoclonal Antibodies in Adult Clinical Trials.
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
Y1 - 2009/09//
VL - 49
IS - 9
M3 - Article
SP - 1012
EP - 1024
SN - 00912700
AB - Although without clear scientific rationale, body size- based dosing is often used for administering monoclonal antibodies (mAbs). This simulation study compared the performance of body size-based and fixed dosing in reducing pharmacokinetic (PK) and/or pharmacodynamic (PD) variability in adults for 12 mAbs with published population PK and/or PD models. At the population level, 95th percentile intervals of concentration-time profiles, distribution, and variability of exposure for 1000 subjects after both dosing approaches were examined. At the individual level, the difference between the exposures of patients with extreme body sizes from the typical exposure following both approaches was compared. The results show that the 2 dosing approaches perform similarly across the mAbs investigated with fixed dosing being better for some mAbs and body size-based dosing being better for the others. Based on this finding, we recommend using fixed dosing in first-in-human (FIH) adult studies because it offers other advantages. When sufficient data become available, a full assessment of body size effect on PK/PD should be conducted to determine the optimal dosing approach for phase 3 trials. Other factors that may affect the selection of dosing approach were also discussed. Dosing approach for mAbs in the pediatric population is out of the scope of this study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADMINISTRATION of drugs
KW - BODY size
KW - BODY weight
KW - MONOCLONAL antibodies
KW - PHARMACOKINETICS
KW - DRUGS -- Physiological effect
KW - biologics
KW - body size-based dosing
KW - body surface area
KW - body weight
KW - Fixed dosing
KW - monoclonal antibodies
KW - pharmacodynamics
KW - population pharmacokinetics
N1 - Accession Number: 44143141; Wang, Diane D. 1; Email Address: diane.wang@pfizer.com Shuzhong Zhang 1 Hong Zhao 2 Men, Angela Y. 2 Parivar, Kourosh 1; Affiliation: 1: Pfizer Oncology, San Diego, California 2: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland; Source Info: Sep2009, Vol. 49 Issue 9, p1012; Subject Term: ADMINISTRATION of drugs; Subject Term: BODY size; Subject Term: BODY weight; Subject Term: MONOCLONAL antibodies; Subject Term: PHARMACOKINETICS; Subject Term: DRUGS -- Physiological effect; Author-Supplied Keyword: biologics; Author-Supplied Keyword: body size-based dosing; Author-Supplied Keyword: body surface area; Author-Supplied Keyword: body weight; Author-Supplied Keyword: Fixed dosing; Author-Supplied Keyword: monoclonal antibodies; Author-Supplied Keyword: pharmacodynamics; Author-Supplied Keyword: population pharmacokinetics; Number of Pages: 13p; Illustrations: 3 Charts, 7 Graphs; Document Type: Article
L3 - 10.1177/0091270009337512
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - YOUNGBONG KIM
AU - YOONJUNG CHOI
AU - SOOHYUN KIM
AU - JONGHYUN PARK
AU - MYONGSOO CHUNG
AU - KYUNG BIN SONG
AU - INGYUN HWANG
AU - KISUNG KWON
AU - JIYONG PARK
T1 - Disinfection of Iceberg Lettuce by Titanium Dioxide-UV Photocatalytic Reaction.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/09//
VL - 72
IS - 9
M3 - Article
SP - 1916
EP - 1922
SN - 0362028X
AB - Securing the physical quality and microbial safety of fresh foods has been a major focus in the food industry. To improve quality and increase the shelf life of fresh produce, disinfection methods have been developed. Titanium dioxide (TiO2) photocatalytic reactions under UV radiation produce hydroxyl radicals that can be used for disinfection of foodborne pathogenic bacteria. We investigated the effects of TiO2-UV photocatalytic disinfection on the shelf life of iceberg lettuce. Counts of natural microflora (total aerobic bacteria, coliforms, psychrotrophic bacteria, and yeasts and molds) and inoculated pathogenic bacteria (Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, and Salmonella Typhimurium) on iceberg lettuce were determined after 20-min treatments with TiO2-UV, UV radiation, a sodium hypochlorite (NaOCI) solution, and tap water. TiO2-UV treatment reduced the number of microorganisms by 1.8 to 2.8 log CFU/g compared with reductions of 0.9 to 1.4 and 0.7 to 1.1 log CFU/g obtained with UV radiation and NaOCI treatments, respectively. Treatment with tap water was used as a control and resulted in no reductions. Counts of microflora for iceberg lettuce at 4 and 25°C were determined during a 9-day period. TiO2-UV treatment resulted in 1.2- and 4.3-log increases in the counts of total aerobic bacteria at 4 and 25°C, respectively, compared with 1.3- to 1.6-log and 4.4- to 4.8-log increases due to UV radiation and NaOCI treatments. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Disinfection & disinfectants
KW - Coliforms
KW - Bacteria
KW - Titanium dioxide
KW - Lettuce
KW - Psychrotrophic organisms
N1 - Accession Number: 44521400; YOUNGBONG KIM 1; YOONJUNG CHOI 1; SOOHYUN KIM 1; JONGHYUN PARK 2; MYONGSOO CHUNG 3; KYUNG BIN SONG 4; INGYUN HWANG 5; KISUNG KWON 5; JIYONG PARK 1; Email Address: foodpro@yonsei.ac.kr; Affiliations: 1: Department of Biotechnology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea; 2: Department of Food Science and Biotechnology, Kyungwon University, 65 Bokjeong-dong, Sujeong-gu, Seongnam 461-701, South Korea; 3: Department of Food Science, Ewha Woman's University, 11-1 Daehyeon-dong, Seodaemun-gu, Seoul 120-750, South Korea; 4: Department of Food Science and Technology. Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, South Korea; 5: Center for Food Safety Evaluation, Korea Food and Drug Administration, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-704, South Korea; Issue Info: Sep2009, Vol. 72 Issue 9, p1916; Thesaurus Term: Disinfection & disinfectants; Thesaurus Term: Coliforms; Thesaurus Term: Bacteria; Subject Term: Titanium dioxide; Subject Term: Lettuce; Subject Term: Psychrotrophic organisms; NAICS/Industry Codes: 325612 Polish and Other Sanitation Good Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 325610 Soap and cleaning compound manufacturing; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 1 Chart, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - GRANT, MICHAEL A.
AU - MOGLER, MARK A.
AU - HARRIS, DELBERT L.
T1 - Comparison of Enrichment Procedures for Shiga Toxin-Producing Escherichia coli in Wastes from Commercial Swine Farms.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/09//
VL - 72
IS - 9
M3 - Article
SP - 1982
EP - 1986
SN - 0362028X
AB - Three methods for enrichment of Shiga toxin-producing Escherichia coli (STEC) were compared using waste pit samples from swine production facilities housing 50 to 3,000 animals. The STEC gene stx2 was detected in 5 of 17 pooled samples using a U.S. Department of Agriculture (USDA) enrichment procedure, 6 of 17 samples using a U.S. Food and Drug Administration (FDA) enrichment procedure, and 8 of 17 samples using an experimental acid enrichment. All isolates were non-O157 and 5 of 6 were positive for enterotoxigenic E. coil-associated heat stable toxins a and b. The three enrichment procedures were also tested for their ability to support growth of 31 strains of STEC. The acid enrichment media supported growth of 100% of the strains, the FDA medium supported 77% of the strains, and the USDA medium supported 16% of the strains. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Escherichia coli
KW - Swine
KW - Farms
KW - Genes
KW - United States
KW - United States. Dept. of Agriculture
KW - United States. Food & Drug Administration
N1 - Accession Number: 44521409; GRANT, MICHAEL A. 1; Email Address: mike.grant@fda.hhs.gov; MOGLER, MARK A. 2; HARRIS, DELBERT L. 2; Affiliations: 1: U.S. Food and Drug Administration, Bothell, Washington 98021-4421; 2: Department of Animal Science, Iowa State University, Ames, Iowa 50010, USA; Issue Info: Sep2009, Vol. 72 Issue 9, p1982; Thesaurus Term: Escherichia coli; Thesaurus Term: Swine; Thesaurus Term: Farms; Subject Term: Genes; Subject: United States ; Company/Entity: United States. Dept. of Agriculture ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112210 Hog and Pig Farming; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 5p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pylypchuk, Yuriy
AD - US Department of Health and Human Services
T1 - Effects of Immigration on the Health Insurance Status of Natives
JO - Journal of Health Economics
JF - Journal of Health Economics
Y1 - 2009/09//
VL - 28
IS - 5
SP - 1028
EP - 1037
SN - 01676296
N1 - Accession Number: 1077453; Keywords: Health; Health Insurance; Immigrant; Immigrant Labor; Immigration; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200912
N2 - The objective of the paper is to estimate the effects of immigration on natives' probability of having private coverage and being uninsured. To examine whether immigrants affected employers' decisions to offer health benefits the study estimates immigration effects on natives' probability of being offered, eligible for, and a policy-holder of health insurance. Although in many cases the effects are statistically significant, most effects are very small. The increase in immigrant labor supply from 1995 to 2005 increases natives' uninsurance rates by about 0.7 percentage points and reduces the natives' probability of being offered and a holder of coverage by 0.8 and 1.9 percentage points, respectively. Immigrants' weaker preferences for coverage relative to natives' may be the key factor in this result.
KW - Analysis of Health Care Markets I11
KW - Health Production I12
KW - Demographic Trends, Macroeconomic Effects, and Forecasts J11
KW - Geographic Labor Mobility; Immigrant Workers J61
L3 - http://www.sciencedirect.com/science/journal/01676296
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UR - http://dx.doi.org/10.1016/j.jhealeco.2009.06.007
UR - http://www.sciencedirect.com/science/journal/01676296
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Hongmei Nan
AU - Kraft, Peter
AU - Qureshi, Abrar A.
AU - Qun Guo
AU - Chen, Constance
AU - Hankinson, Susan E.
AU - Hu, Frank B.
AU - Thomas, Gilles
AU - Hoover, Robert N.
AU - Chanock, Stephen
AU - Hunter, David J.
AU - Han, Jiali
T1 - Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry.
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
Y1 - 2009/09//
VL - 129
IS - 9
M3 - Article
SP - 2250
EP - 2257
SN - 0022202X
AB - We conducted a multistage genome-wide association study (GWAS) of tanning response after exposure to sunlight in over 9,000 men and women of European ancestry who live in the United States. An initial analysis of 528,173 single-nucleotide polymorphisms (SNPs) genotyped on 2,287 women identified LOC401937 (rs966321) on chromosome 1 as a novel locus highly associated with tanning ability, and we confirmed this association in 870 women controls from a skin cancer case–control study with joint P-value=1.6 × 10−9. We further genotyped this SNP in two subsequent replication studies (one with 3,750 women and the other with 2,405 men). This association was not replicated in either of these two studies. We found that several SNPs reaching the genome-wide significance level are located in or adjacent to the loci previously known as pigmentation genes: MATP, IRF4, TYR, OCA2, and MC1R. Overall, these tanning ability–related loci are similar to the hair color–related loci previously reported in the GWAS of hair color.Journal of Investigative Dermatology (2009) 129, 2250–2257; doi:10.1038/jid.2009.62; published online 02 April 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Investigative Dermatology is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHENOTYPE
KW - GENOTYPE-environment interaction
KW - GENETICS
KW - SKIN diseases
KW - POLYMORPHISM (Zoology)
KW - SUNTAN
N1 - Accession Number: 43664286; Hongmei Nan 1,2,3; Email Address: hnan@hsph.harvard.edu Kraft, Peter 2,3 Qureshi, Abrar A. 1 Qun Guo 1,3 Chen, Constance 2,3 Hankinson, Susan E. 1,2 Hu, Frank B. 1,2,4 Thomas, Gilles 5 Hoover, Robert N. 5 Chanock, Stephen 5 Hunter, David J. 1,2,3,4,5,6 Han, Jiali 1,3; Affiliation: 1: Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA 2: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 3: Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA 4: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA 5: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA 6: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Source Info: Sep2009, Vol. 129 Issue 9, p2250; Subject Term: PHENOTYPE; Subject Term: GENOTYPE-environment interaction; Subject Term: GENETICS; Subject Term: SKIN diseases; Subject Term: POLYMORPHISM (Zoology); Subject Term: SUNTAN; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1038/jid.2009.62
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43664286&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schulte, Paul A.
AU - Chun, HeeKyoung
T1 - Climate Change and Occupational Safety and Health: Establishing a Preliminary Framework.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/09//
VL - 6
IS - 9
M3 - Article
SP - 542
EP - 554
PB - Taylor & Francis Ltd
SN - 15459624
AB - The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Climatic changes
KW - Industrial safety
KW - Occupational hazards
KW - Toxic substance exposure
KW - Industrial hygiene
KW - Work environment
KW - biological hazards
KW - climate change
KW - heat stress
KW - UV radiation
KW - worker health
N1 - Accession Number: 75127864; Schulte, Paul A. 1; Chun, HeeKyoung 1; Affiliations: 1: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio; Issue Info: Sep2009, Vol. 6 Issue 9, p542; Thesaurus Term: Climatic changes; Thesaurus Term: Industrial safety; Thesaurus Term: Occupational hazards; Thesaurus Term: Toxic substance exposure; Thesaurus Term: Industrial hygiene; Subject Term: Work environment; Author-Supplied Keyword: biological hazards; Author-Supplied Keyword: climate change; Author-Supplied Keyword: heat stress; Author-Supplied Keyword: UV radiation; Author-Supplied Keyword: worker health; Number of Pages: 13p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1080/15459620903066008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127864&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105379922
T1 - Climate change and occupational safety and health: establishing a preliminary framework.
AU - Schulte PA
AU - Chun H
Y1 - 2009/09//
N1 - Accession Number: 105379922. Language: English. Entry Date: 20090724. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Climate
KW - Occupational Hazards -- Classification
KW - Climate Change
KW - Air Pollution
KW - Occupational Safety
KW - Weather
KW - Work Environment
SP - 542
EP - 554
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 9
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks.
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226; PSchulte@cdc.gov
U2 - PMID: 19551548.
DO - 10.1080/15459620903066008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105379922&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Syamlal, Girija
AU - Mazurek, Jacek M.
AU - Ki Moon Bang
T1 - Prevalence of Lifetime Asthma and Current Asthma Attacks in U.S. Working Adults: An Analysis of the 1997-2004 National Health Interview Survey Data.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2009/09//
VL - 51
IS - 9
M3 - Article
SP - 1066
EP - 1074
SN - 10762752
AB - The article reports on the result of the study conducted to estimate prevalence of lifetime asthma and current asthma attacks of working adults in the U.S. The study includes an analysis of the data fro the 1997-2004 National Health Interview Survey for currently working adults aged 18 years and over. Result shows that the lifetime asthma prevalence was 9.2 percent while noting the highest asthma prevalence were from the membership organizations industry and the health service occupation.
KW - ASTHMA
KW - OCCUPATIONAL diseases
KW - OBSTRUCTIVE lung diseases
KW - MEDICAL personnel
KW - UNITED States
N1 - Accession Number: 44494954; Syamlal, Girija 1; Email Address: gos2@cdc.gov Mazurek, Jacek M. 1 Ki Moon Bang 1; Affiliation: 1: Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa; Source Info: Sep2009, Vol. 51 Issue 9, p1066; Subject Term: ASTHMA; Subject Term: OCCUPATIONAL diseases; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: MEDICAL personnel; Subject Term: UNITED States; Number of Pages: 9p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1097/JOM.0b013e3181b3510a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44494954&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105440092
T1 - Prevalence of lifetime asthma and current asthma attacks in U.S. working adults: an analysis of the 1997--2004 National Health Interview Survey data.
AU - Syamlal G
AU - Mazurek JM
AU - Bang KM
Y1 - 2009/09//
N1 - Accession Number: 105440092. Language: English. Entry Date: 20091127. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Asthma -- Epidemiology
KW - Workforce
KW - Adult
KW - Age Factors
KW - Aged
KW - Blacks
KW - Confidence Intervals
KW - Cross Sectional Studies
KW - Data Analysis Software
KW - Data Analysis, Statistical
KW - Descriptive Statistics
KW - Female
KW - Hispanics
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - Race Factors
KW - Self Report
KW - Sex Factors
KW - Smoking -- Epidemiology
KW - Surveys
KW - Whites
KW - Human
SP - 1066
EP - 1074
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 51
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: To estimate national prevalences of lifetime asthma and asthma attacks among workers by age, sex, race, occupation and industry, and estimate population attributable fraction to employment for asthma attacks in the United States. METHODS: The 1997-2004 National Health Interview Survey data for currently working adults aged > or = 18 years were analyzed. RESULTS: Lifetime asthma prevalence was 9.2%; the social services religious and membership organizations industry and the health service occupation had the highest asthma prevalence. Asthma attack prevalence among workers with asthma was 35.4%; the primary metal industry and the health assessment and treating occupation had the highest attack prevalence. Approximately, 5.9% of cases reporting an asthma attack were attributed to employment when considering industries and 3.8% when considering occupations. CONCLUSIONS: Future studies and intervention strategies should address the higher prevalence of asthma in certain industries and occupations.
SN - 1076-2752
AD - Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505; gos2@cdc.gov
U2 - PMID: 19730397.
DO - 10.1097/JOM.0b013e3181b3510a
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105440092&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105425132
T1 - Spectrum of central anticholinergic adverse effects associated with oxybutynin: comparison of pediatric and adult cases.
AU - Gish P
AU - Mosholder AD
AU - Truffa M
AU - Johann-Liang R
Y1 - 2009/09//
N1 - Accession Number: 105425132. Language: English. Entry Date: 20091016. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0375410.
KW - Adverse Drug Event
KW - Antiinfective Agents, Urinary -- Adverse Effects
KW - Muscarinic Antagonists -- Adverse Effects
KW - Nervous System Diseases -- Chemically Induced
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Antiinfective Agents, Urinary -- Administration and Dosage
KW - Central Nervous System -- Drug Effects
KW - Child
KW - Child, Preschool
KW - Databases
KW - Enuresis -- Drug Therapy
KW - Infant
KW - Middle Age
KW - Muscarinic Antagonists -- Administration and Dosage
SP - 432
EP - 434
JO - Journal of Pediatrics
JF - Journal of Pediatrics
JA - J PEDIATR
VL - 155
IS - 3
CY - New York, New York
PB - Elsevier Science
SN - 0022-3476
AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, The United States Food and Drug Administration, Silver Spring, MD 20993, USA. paula.gish@fda.hhs.gov
U2 - PMID: 19732583.
DO - 10.1016/j.jpeds.2009.01.074
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105425132&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Chisolm, Deena J.
AU - Mulatu, Mesfin S.
AU - Brown, Jorielle R.
T1 - Racial/ethnic disparities in the patterns of co-occurring mental health problems in adolescents in substance abuse treatment
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
Y1 - 2009/09//
VL - 37
IS - 2
M3 - Article
SP - 203
EP - 210
SN - 07405472
AB - Abstract: This study examines disparities in co-occurring mental health and substance use problems by race/ethnicity to inform the development of culturally appropriate treatment approaches. Using pooled clinical data collected with the Global Assessment of Individual Needs, we identified racial/ethnic and other factors associated with co-occurring internalizing problems, externalizing problems, and the combination thereof in adolescents in federally funded treatment facilities. Results show that after controlling for demographic and socioenvironmental factors, African Americans, Hispanics, and mixed-race adolescents were more likely than Whites to have co-occurring internalizing problems. African Americans and Native Americans were less likely than Whites to have externalizing problems and to have combined internalizing and externalizing problems. Presence of co-occurring problems was also associated with victimization, homelessness, and family substance abuse. These results indicate that co-occurring mental health problems vary by race/ethnicity, and therefore, refined approaches are needed for culturally appropriate care of patients. [Copyright &y& Elsevier]
AB - Copyright of Journal of Substance Abuse Treatment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SUBSTANCE abuse -- Treatment
KW - ADOLESCENT psychology
KW - MENTAL health
KW - MEDICAL records
KW - CULTURAL pluralism
KW - AFRICAN American men
KW - DISEASES
KW - MEDICAL anthropology
KW - Adolescence
KW - Disparities
KW - Mental health
KW - Substance use
N1 - Accession Number: 43409711; Chisolm, Deena J. 1,2; Email Address: deena.chisolm@nationwidechildrens.org Mulatu, Mesfin S. 3 Brown, Jorielle R. 4; Affiliation: 1: Center for Innovation in Pediatric Practice, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA 2: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA 3: The MayaTech Corporation, Silver Spring, MD 20910, USA 4: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA; Source Info: Sep2009, Vol. 37 Issue 2, p203; Subject Term: SUBSTANCE abuse -- Treatment; Subject Term: ADOLESCENT psychology; Subject Term: MENTAL health; Subject Term: MEDICAL records; Subject Term: CULTURAL pluralism; Subject Term: AFRICAN American men; Subject Term: DISEASES; Subject Term: MEDICAL anthropology; Author-Supplied Keyword: Adolescence; Author-Supplied Keyword: Disparities; Author-Supplied Keyword: Mental health; Author-Supplied Keyword: Substance use; NAICS/Industry Codes: 621330 Offices of Mental Health Practitioners (except Physicians); NAICS/Industry Codes: 621420 Outpatient Mental Health and Substance Abuse Centers; NAICS/Industry Codes: 622210 Psychiatric and Substance Abuse Hospitals; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jsat.2008.11.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43409711&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY -
AU - POON, ERIC G.1,2, epoon@partners.org
AU - CUSACK, CAITLIN M.3,4
AU - MCGOWAN, JULIE J.4,5,6
T1 - Evaluating Healthcare Information Technology Outside of Academia: Observations from the National Resource Center for Healthcare Information Technology at the Agency for Healthcare Research and Quality.
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
J1 - Journal of the American Medical Informatics Association
PY - 2009/09//Sep/Oct2009
Y1 - 2009/09//Sep/Oct2009
VL - 16
IS - 5
CP - 5
M3 - Article
SP - 631
EP - 636
SN - 10675027
AB - The National Resource Center for Health Information Technology (NRC) was formed in the fall of 2004 as part of the Agency for Healthcare Research and Quality (AHRQ) health IT portfolio to support its grantees. One of the core functions of the NRC was to assist grantees in their evaluation efforts of Health IT. This manuscript highlights some common challenges experienced by health IT project teams at nonacademic institutions, including inappropriately scoped and resourced evaluation efforts, inappropriate choice of metrics, inadequate planning for data collection and analysis, and lack of consideration of qualitative methodologies. Many of these challenges can be avoided or overcome. The strategies adopted by various AHRQ grantees and the lessons learned from their projects should become part of the toolset for current and future implementers of health IT as the nation moves rapidly towards its widespread adoption. [ABSTRACT FROM AUTHOR]
KW - Information resources -- Research
KW - Computers in medicine
KW - Medical informatics
KW - Information technology -- Evaluation
KW - Medical care
KW - Health education -- Research
N1 - Accession Number: 44703557; Authors: POON, ERIC G. 1,2 Email Address: epoon@partners.org; CUSACK, CAITLIN M. 3,4; MCGOWAN, JULIE J. 4,5,6; Affiliations: 1: Brigham and Women's Hospital, Boston, MA.; 2: Harvard Medical School, Boston, MA.; 3: National Opinion Research Center, University of Chicago, Office in Bethesda, MD.; 4: National Resource Center for Healthcare Information Technology, Agency of Healthcare Research and Quality, Rockville, MD.; 5: Indiana University School of Medicine, Indianapolis, IN.; 6: Regenstrief Institute, Inc., Indianapolis, IN.; Subject: Information technology -- Evaluation; Subject: Information resources -- Research; Subject: Medical care; Subject: Health education -- Research; Subject: Computers in medicine; Subject: Medical informatics; Number of Pages: 6p; Illustrations: 1 Chart; Record Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=lls&AN=44703557&site=ehost-live&scope=site
DP - EBSCOhost
DB - lls
ER -
TY - JOUR
ID - 105225628
T1 - Unique role of consumer studies in nonprescription drug development.
AU - Leonard-Segal A
AU - Shay LE
AU - Shetty D
AU - Schiffenbauer J
Y1 - 2009/09//Sep/Oct2009
N1 - Accession Number: 105225628. Language: English. Entry Date: 20110114. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 101176252.
KW - Consumer Participation -- Methods
KW - Drug Approval
KW - Drugs, Non-Prescription -- Administration and Dosage
KW - Clinical Trials
KW - Readability
KW - Drug Labeling
KW - Human
KW - Self Medication
SP - 670
EP - 673
JO - Journal of the American Pharmacists Association: JAPhA
JF - Journal of the American Pharmacists Association: JAPhA
JA - J AM PHARM ASSOC
VL - 49
IS - 5
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 1544-3191
AD - Division of Nonprescription Clinical Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.
U2 - PMID: 19748876.
DO - 10.1331/JAPhA.2009.08068
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105225628&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Huang, Lan
AU - Tiwari, Ram C.
AU - Zou, Zhaohui
AU - Kulldorff, Martin
AU - Feuer, Eric J.
AD - National Cancer Institute, Rockville, MD
AD - Food and Drug Administration, Silver Spring, MD
AD - Information Management Services Inc, Silver Spring, MD
AD - Harvard U and Harvard Pilgrim Health Care, Boston, MA
AD - National Cancer Institute, Rockville, MD
T1 - Weighted Normal Spatial Scan Statistic for Heterogeneous Population Data
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/09//
VL - 104
IS - 487
SP - 886
EP - 898
SN - 01621459
N1 - Accession Number: 1144845; Keywords: Cancer; Census; Disease; Heterogeneity; Mortality; Mortality Rates; Population; Regional; Spatial; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 201012
N2 - In geographical spatial epidemiology and disease surveillance, all the existing spatial scan methods for cluster detection using continuous data are designed for evaluating clusters of individuals and analyzing individual-level data. Motivated by growing demands to study the spatial heterogeneity of continuous measures in population data, such as mortality rates, survival rates, average body mass indexes and pollution at state, county, and census tract levels, we propose a weighted normal scan statistic for investigating the clusters of the cells (geographic units such as counties) with unusual high/low continuous regional measures, where the weights reflect the uncertainty of the regional measures or sample size (number of observed cases) in the cells. Power, precision, the effect of the weights, and the sensitivity of the proposed test statistic to data from various distributions are investigated through intensive simulation. The method is applied to 1988-2002 stage I and II lung cancer survival data in Los Angeles County in order to search for clusters of geographic units with high/low survival rates in a short-term/long-term survival after diagnosis, and to 1999-2003 breast cancer age-adjusted mortality rate data in the U.S. collected by the Surveillance, Epidemiology and End Results (SEER) program in order to evaluate the clustering pattern of counties with high mortality rate.
KW - Single Equation Models; Single Variables: Cross-Sectional Models; Spatial Models; Treatment Effect Models; Quantile Regressions C21
KW - Model Construction and Estimation C51
KW - Health Production I12
KW - Valuation of Environmental Effects Q51
KW - Urban, Rural, Regional, Real Estate, and Transportation Economics: Regional Migration; Regional Labor Markets; Population; Neighborhood Characteristics R23
L3 - http://amstat.tandfonline.com/loi/uasa20
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UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Xu, Qiang
AU - Paik, Myunghee Cho
AU - Luo, Xiaodong
AU - Tsai, Wei-Yann
AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
AD - Columbia U
AD - Mount Sinai School of Medicine, Bronx, NY
AD - Columbia U
T1 - Reweighting Estimators for Cox Regression with Missing Covariates
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/09//
VL - 104
IS - 487
SP - 1155
EP - 1167
SN - 01621459
N1 - Accession Number: 1144871; Publication Type: Journal Article; Update Code: 201012
N2 - Missingness in covariates is a common problem in survival data. In this article we propose a reweighting method for estimating the regression parameters in the Cox model with missing covariates. We also consider the augmented reweighting method by subtracting the projection term onto the nuisance tangent space. The proposed method provides consistent and asymptotically normally distributed estimators when the missing-data mechanism depends on the outcome variables, as well as on the observed covariates with either monotone or arbitrary nonmonotone missingness patterns. Simulation results indicate that in most situations, the proposed reweighting estimators are more efficient than the inverse probability weighting estimators for the regression coefficients of the missing covariates and are as efficient as or more efficient than the inverse probability weighting estimators for the regression coefficients of the completely observed covariates. The simple reweighting estimators can be easily implemented in standard statistical packages.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
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UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Othus, Megan
AU - Li, Yi
AU - Tiwari, Ram C.
AD - Harvard U
AD - Harvard U
AD - US Food and Drug Administration, Silver Springs, MD
T1 - A Class of Semiparametric Mixture Cure Survival Models with Dependent Censoring
JO - Journal of the American Statistical Association
JF - Journal of the American Statistical Association
Y1 - 2009/09//
VL - 104
IS - 487
SP - 1241
EP - 1250
SN - 01621459
N1 - Accession Number: 1144879; Publication Type: Journal Article; Update Code: 201012
N2 - Modern cancer treatments have substantially improved cure rates and have generated a great interest in and need for proper statistical tools to analyze survival data with nonnegligible cure fractions. Data with cure fractions often are complicated by dependent censoring, and the analysis of this type of data typically involves untestable parametric assumptions on the dependence of the censoring mechanism and the true survival times. Motivated by the analysis of prostate cancer survival trends, we propose a class of semiparametric transformation cure models that allows for dependent censoring without making parametric assumptions on the dependence relationship. The proposed class of models encompasses a number of common models for the latency survival function, including the proportional hazards model and the proportional odds model, and also allows for time-dependent covariates. An inverse censoring probability reweighting scheme is used to derive unbiased estimating equations. Small-sample properties with simulations are derived, and the method is demonstrated with a data application.
KW - Related Disciplines Y80
L3 - http://amstat.tandfonline.com/loi/uasa20
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UR - http://amstat.tandfonline.com/loi/uasa20
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - Marrero-Ortiz, Roberto
AU - Riley, Kelley R.
AU - Karpiscak, Martin K.
AU - Gerbaa, Charles P.
T1 - Groundwater quality of individual wells and small systems in Arizona.
JO - Journal: American Water Works Association
JF - Journal: American Water Works Association
Y1 - 2009/09//
VL - 101
IS - 9
M3 - Article
SP - 89
EP - 100
SN - 0003150X
AB - Approximately half of the waterborne disease outbreaks documented annually in the United States are caused by contaminated groundwater. In 2006, the US Environmental Protection Agency promulgated the final Ground Water Rule to reduce the risk of exposure to fecal contamination that may be present in community and noncommunity public groundwater systems. In most states, private drinking water systems are not regulated by local health and environmental agencies. The goal of the study presented in this article was to assess the microbial, physical, and chemical quality of groundwater in individual wells and small public water systems in Arizona, and it was the first such study in an arid region of the United States. Of the well sites sampled, 43% of the systems were positive for total coliforms, 16% for fecal coliforms, and 4% for Escherichia coli. In addition, 95% of systems exceeded at least one primary and/or secondary drinking water standard, suggesting that better guidance is needed to ensure the water quality of these systems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal: American Water Works Association is the property of American Water Works Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLLUTION
KW - Fecal contamination
KW - Groundwater -- Research
KW - Waterborne infection -- Transmission
KW - Groundwater
KW - UNITED States
KW - Drinking water -- Safety measures
KW - Arizona
KW - United States
KW - United States. Environmental Protection Agency
N1 - Accession Number: 44232399; Marrero-Ortiz, Roberto 1; Riley, Kelley R. 2; Karpiscak, Martin K. 3; Gerbaa, Charles P. 4; Email Address: gerba@ag.arizona.edu; Affiliations: 1: US Food and Drug Administration Gulf Coast Seafood Laboratory in Dauphin Island, Ala.; 2: University of Arizona, Maricopa Agricultural Center; 3: Office of Arid Lands Studies, University of Arizona, Tucson; 4: Department of Soil, Water, and Environmental Science, University of Arizona, Bldg. 38, Rm. 429, Tucson, AZ 85721; Issue Info: Sep2009, Vol. 101 Issue 9, p89; Thesaurus Term: POLLUTION; Thesaurus Term: Fecal contamination; Thesaurus Term: Groundwater -- Research; Subject Term: Waterborne infection -- Transmission; Subject Term: Groundwater; Subject Term: UNITED States; Subject Term: Drinking water -- Safety measures; Subject: Arizona; Subject: United States ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 12p; Illustrations: 6 Color Photographs, 6 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Curran, Christine P.
AU - Park, Robert M.
AU - Ho, Shuk-mei
AU - Haynes, Erin N.
T1 - Incorporating genetics and genomics in risk assessment for inhaled manganese: From data to policy
JO - NeuroToxicology
JF - NeuroToxicology
Y1 - 2009/09//
VL - 30
IS - 5
M3 - Article
SP - 754
EP - 760
SN - 0161813X
AB - Abstract: Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body''s normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1mg/m3) in air leads to a Parkinsonian syndrome known as “manganism.” Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2mg/m3) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed. [Copyright &y& Elsevier]
AB - Copyright of NeuroToxicology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH risk assessment
KW - MANGANESE -- Physiological effect
KW - NEUROTOXICOLOGY
KW - GENOMICS
KW - HOMEOSTASIS
KW - BIOACCUMULATION
KW - SYMPTOMATIC Parkinson's disease
KW - INDIVIDUAL differences
KW - DNA
KW - Epidemiology
KW - Genetic susceptibility
KW - Manganese
KW - Occupational health
KW - Policy
N1 - Accession Number: 44581314; Curran, Christine P. 1; Email Address: curranc1@nku.edu Park, Robert M. 2 Ho, Shuk-mei 3 Haynes, Erin N. 3; Affiliation: 1: Department of Biological Sciences, Northern Kentucky University, SC342 Nunn Drive, Highland Heights, KY 41099, United States 2: Risk Evaluation Branch, National Institute for Occupational Safety and Health, United States 3: Department of Environmental Health, University of Cincinnati College of Medicine, United States; Source Info: Sep2009, Vol. 30 Issue 5, p754; Subject Term: HEALTH risk assessment; Subject Term: MANGANESE -- Physiological effect; Subject Term: NEUROTOXICOLOGY; Subject Term: GENOMICS; Subject Term: HOMEOSTASIS; Subject Term: BIOACCUMULATION; Subject Term: SYMPTOMATIC Parkinson's disease; Subject Term: INDIVIDUAL differences; Author-Supplied Keyword: DNA; Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: Genetic susceptibility; Author-Supplied Keyword: Manganese; Author-Supplied Keyword: Occupational health; Author-Supplied Keyword: Policy; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuro.2009.07.013
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Adam K.
AU - Kovalchik, Peter G.
AU - Alcorn, Lynn A.
AU - Matetic, Rudy J.
T1 - A dual sprocket chain as a noise control for a continuous mining machine).
JO - Noise Control Engineering Journal
JF - Noise Control Engineering Journal
Y1 - 2009/09//Sep/Oct2009
VL - 57
IS - 5
M3 - Article
SP - 413
EP - 419
PB - Institute of Noise Control Engineering of the USA
SN - 07362501
AB - Over-exposure to noise remains a widespread, serious health hazard in the U.S. mining industry despite 25 years of regulation. Most other categories of illnesses and injuries associated with mining have improved, with the exception of hearing loss. In order to reduce cases of Noise Induced Hearing Loss (NIHL) in the mining industry, retrofit acoustic treatments and controls are being developed to subdue noise at the source. The Mine Safety and Health Administration (MSHA) coal noise sample data collected from 2000 to 2005 has determined that continuous mining machines rank first among all mining equipment whose operators exceed 100% noise dosage. The continuous mining machine conveyor, used to move coal from the cutting face to the rear of the machine, has been identified as a dominant noise source. A dual sprocket conveyor chain was tested as a potential solution. Sound power level measurements conducted at the Pittsburgh Research Laboratory (PRL) accredited reverberation chamber showed a 3 dB reduction in the A-weighted sound power level when the dual sprocket chain was implemented. Underground results show an 8-hour Time Weighted Average (TWA8 hrs) reduction a 3 dB for continuous mining machine operators. Utilizing this newly developed noise control, along with previously proven controls, provides continuous mining machine operators an opportunity to be within the MSHA-Permissible Exposure Limit (MSHA-PEL). [ABSTRACT FROM AUTHOR]
AB - Copyright of Noise Control Engineering Journal is the property of Institute of Noise Control Engineering of the USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Mining machinery
KW - Noise control
KW - Deafness -- Prevention
KW - Industrial hygiene
KW - Mine safety -- Government policy
KW - United States
KW - United States. Mine Safety & Health Administration
N1 - Accession Number: 49313936; Smith, Adam K. 1; Email Address: eyv7@cdc.gov; Kovalchik, Peter G. 1; Alcorn, Lynn A. 1; Matetic, Rudy J. 1; Affiliations: 1: National Institute of Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, Cochrans Mill Road, Pittsburgh PA 15236.; Issue Info: Sep/Oct2009, Vol. 57 Issue 5, p413; Thesaurus Term: RESEARCH; Subject Term: Mining machinery; Subject Term: Noise control; Subject Term: Deafness -- Prevention; Subject Term: Industrial hygiene; Subject Term: Mine safety -- Government policy; Subject: United States ; Company/Entity: United States. Mine Safety & Health Administration; NAICS/Industry Codes: 423810 Construction and Mining (except Oil Well) Machinery and Equipment Merchant Wholesalers; NAICS/Industry Codes: 417220 Mining and oil and gas well machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 333131 Mining Machinery and Equipment Manufacturing; NAICS/Industry Codes: 333130 Mining and oil and gas field machinery manufacturing; Number of Pages: 7p; Illustrations: 4 Black and White Photographs, 1 Diagram, 3 Charts, 5 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Weil, Kathleen M.
T1 - Alarming monitor problems.
JO - Nursing
JF - Nursing
Y1 - 2009/09//
VL - 39
IS - 9
M3 - Article
SP - 58
EP - 58
SN - 03604039
AB - The article examines the causes of patient deaths and the malfunction of continuous cardiac monitors. Examples are given of three patients whose monitors did not detect ventricular fibrillation as a result of the improper installation of dysrhythmia recognition software. A list of precautions that healthcare providers can take to prevent alarm-related adverse events and ECRI Institute's hazards for clinicians are presented.
KW - MONITOR alarms (Medicine)
KW - SOFTWARE failures
KW - CARDIAC arrest
KW - PATIENTS
KW - EARLY death
KW - PATIENTS -- Safety measures
N1 - Accession Number: 44150480; Weil, Kathleen M. 1; Affiliation: 1: Nurse consultant and analyst, Office of Surveillance and Biometrics, Center for Devices and Radiological Health; Source Info: Sep2009, Vol. 39 Issue 9, p58; Subject Term: MONITOR alarms (Medicine); Subject Term: SOFTWARE failures; Subject Term: CARDIAC arrest; Subject Term: PATIENTS; Subject Term: EARLY death; Subject Term: PATIENTS -- Safety measures; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105423542
T1 - Device safety. Alarming monitor problems.
AU - Weil KM
Y1 - 2009/09//
N1 - Accession Number: 105423542. Language: English. Entry Date: 20091009. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety. NLM UID: 7600137.
KW - Equipment Alarm Systems
KW - Equipment Failure
KW - Equipment Safety
KW - Monitoring, Physiologic -- Equipment and Supplies
KW - Nursing Practice
SP - 58
EP - 58
JO - Nursing
JF - Nursing
JA - NURSING
VL - 39
IS - 9
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 0360-4039
AD - Office of Surveillance and Biometrics, Center for Devices and Radiological Health, FDA, Rockville, MD
U2 - PMID: 19701021.
DO - 10.1097/01.NURSE.0000360252.10823.b8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105423542&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Petersen, M. R.
AU - Deddens, J. A.
T1 - A revised SAS macro for maximum likelihood estimation of prevalence ratios using the COPY method.
JO - Occupational & Environmental Medicine
JF - Occupational & Environmental Medicine
Y1 - 2009/09//
VL - 66
IS - 9
M3 - Letter
SP - 639
EP - 639
SN - 13510711
AB - A letter to the editor is presented in response to the article "Approaches for Estimating Prevalence Ratios" that was published in the previous issues.
KW - Letters to the editor
KW - Ratio analysis
N1 - Accession Number: 44143159; Petersen, M. R. 1; Email Address: mrp1@one.net; Deddens, J. A. 1,2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA; 2: Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio, USA; Issue Info: Sep2009, Vol. 66 Issue 9, p639; Subject Term: Letters to the editor; Subject Term: Ratio analysis; Number of Pages: 1p; Document Type: Letter
L3 - 10.1136/oem.2008.043018
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105244127
T1 - What have I done?
AU - Prentice DL
Y1 - 2009/09//Sep-Nov2009
N1 - Accession Number: 105244127. Language: English. Entry Date: 20100122. Revision Date: 20150820. Publication Type: Journal Article. Journal Subset: Editorial Board Reviewed; Nursing; Peer Reviewed; USA. NLM UID: 19330740R.
KW - Mentorship
KW - Nursing Role
SP - 8
EP - 8
JO - Oklahoma Nurse
JF - Oklahoma Nurse
JA - OKLA NURSE
VL - 54
IS - 3
CY - Oklahoma City, Oklahoma
PB - Oklahoma Nurses Association
SN - 0030-1787
AD - United States Air Force, Office of the Surgeon General, USA.
U2 - PMID: 19757741.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105120236
T1 - Approval summary: pemetrexed in the initial treatment of advanced/metastatic non-small cell lung cancer.
AU - Cohen MH
AU - Justice R
AU - Pazdur R
Y1 - 2009/09//
N1 - Accession Number: 105120236. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 9607837.
KW - Carcinoma, Non-Small-Cell Lung -- Drug Therapy
KW - Carcinoma, Squamous Cell -- Drug Therapy
KW - Clinical Trials
KW - Drug Approval
KW - Lung Neoplasms -- Drug Therapy
KW - Pemetrexed -- Therapeutic Use
KW - Purines -- Analogs and Derivatives
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Antineoplastic Agents, Combined
KW - Carcinoma, Non-Small-Cell Lung -- Mortality
KW - Carcinoma, Squamous Cell -- Mortality
KW - Cisplatin -- Administration and Dosage
KW - Cisplatin -- Therapeutic Use
KW - Deoxycytidine
KW - Deoxycytidine -- Administration and Dosage
KW - Deoxycytidine -- Therapeutic Use
KW - Female
KW - Human
KW - Lung Neoplasms -- Mortality
KW - Male
KW - Middle Age
KW - Pemetrexed -- Administration and Dosage
KW - Pemetrexed -- Adverse Effects
KW - Prognosis
KW - Purines -- Administration and Dosage
KW - Purines -- Adverse Effects
KW - Purines -- Therapeutic Use
KW - Survival Analysis
KW - Time Factors
KW - United States
KW - United States Food and Drug Administration
SP - 930
EP - 935
JO - Oncologist
JF - Oncologist
JA - ONCOLOGIST
VL - 14
IS - 9
CY - Durham, North Carolina
PB - AlphaMed Company, Inc., dba AlphaMed Press
AB - On September 26, 2008, the U.S. Food and Drug Administration approved pemetrexed injection (Alimta Injection; Eli Lilly and Company, Indianapolis, IN) for use in combination with cisplatin for the initial treatment of patients with stage IIIB/IV nonsquamous non-small cell lung cancer (NSCLC). A randomized, phase III, open-label study was conducted in 1,725 patients. Patients were randomly assigned to receive 21-day cycles of pemetrexed plus cisplatin (AC) or gemcitabine plus cisplatin (GC). The primary objective was overall survival. The median survival time was 10.3 months in both the AC arm and the GC arm (adjusted hazard ratio [HR], 0.94; 95% confidence interval [CI], 0.84-1.05). The median progression-free survival times were 4.8 and 5.1 months for the AC and GC arms, respectively (adjusted HR, 1.04; 95% CI, 0.94-1.15). The overall response rates were 27.1% and 24.7% for the AC and GC arms, respectively. A prespecified analysis of the impact of NSCLC histology on overall survival was conducted. In the nonsquamous NSCLC subgroup, the median survival times were 11.0 and 10.1 months in the AC and GC groups, respectively (unadjusted HR, 0.84; 95% CI, 0.74-0.96). However, in the squamous cell histology subgroup, the median survival times were 9.4 versus 10.8 months in the AC and GC groups, respectively (unadjusted HR, 1.22; 95% CI, 0.99-1.50). This unfavorable effect of squamous histology on overall survival was also noted in a retrospective analysis of a trial that compared pemetrexed with docetaxel in NSCLC patients who received prior chemotherapy. No new pemetrexed safety signals were observed.
SN - 1083-7159
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak Campus, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov
U2 - PMID: 19737998.
DO - 10.1634/theoncologist.2009-0092
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Zhang, Yi-Min
AU - Peng, Jun
AU - Hu, Chang-Ping
AU - Jiang, Qiu-Tao
AU - Jiang, Guo-Long
AU - Li, Yuan-Jian
T1 - Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells
JO - Peptides
JF - Peptides
Y1 - 2009/09//
VL - 30
IS - 9
M3 - Article
SP - 1746
EP - 1752
SN - 01969781
AB - Abstract: The present study was to determine whether clonidine could induce calcitonin gene-related peptide (CGRP) production and the underlying mechanisms. Human umbilical vein endothelial cells were treated with clonidine and the dose–effect or time–effect relationship of clonidine on CGRP production was examined. Youhimbine (a α2-adrenoceptor blocker) and l-NAME (an antagonist of nitric oxide synthase, NOS) were chosen to explore the role of α2-adrenoceptor and nitric oxide pathway in the effect of clonidine on endothelial cell-derived CGRP production. The level of CGRP mRNA or protein was detected by Real Time-PCR or radioimmunoassay. Nitric oxide content was measured by nitroreduction assay. The study showed that clonidine was able to induce CGRP mRNA (α- and β-isoforms) expression in a dose-dependent manner in endothelial cells. The effect of clonidine on endothelial cell-derived CGRP synthesis and secretion was attenuated in the presence of youhimbine. l-NAME treatment could also inhibit clonidine-induced CGRP synthesis and secretion concomitantly with the decreased NO content in culture medium. These results suggest that clonidine could stimulate CGRP synthesis and secretion in endothelial cells through the activation of α2-adrenoceptor, which is related to the NO pathway. [Copyright &y& Elsevier]
AB - Copyright of Peptides is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLONIDINE
KW - CALCITONIN gene-related peptide
KW - GENE expression
KW - CELLULAR signal transduction
KW - ENDOTHELIUM
KW - NITRIC-oxide synthases -- Inhibitors
KW - ADRENERGIC receptors
KW - MESSENGER RNA
KW - RADIOIMMUNOASSAY
KW - α2-Adrenoceptor
KW - Calcitonin gene-related peptide
KW - Clonidine
KW - Nitric oxide
N1 - Accession Number: 43609561; Zhang, Yi-Min 1,2 Peng, Jun 1,3 Hu, Chang-Ping 1 Jiang, Qiu-Tao 2 Jiang, Guo-Long 2 Li, Yuan-Jian 1; Email Address: yuan_jianli@yahoo.com; Affiliation: 1: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, 110 Xiang-Ya Road, Changsha, Hunan 410078, China 2: Hunan Yongzhou Food and Drug Administration, Yongzhou, Hunan 425600, China 3: Institute of Hypertension, Xiang-Ya Hospital of Central South University, Changsha 410008, China; Source Info: Sep2009, Vol. 30 Issue 9, p1746; Subject Term: CLONIDINE; Subject Term: CALCITONIN gene-related peptide; Subject Term: GENE expression; Subject Term: CELLULAR signal transduction; Subject Term: ENDOTHELIUM; Subject Term: NITRIC-oxide synthases -- Inhibitors; Subject Term: ADRENERGIC receptors; Subject Term: MESSENGER RNA; Subject Term: RADIOIMMUNOASSAY; Author-Supplied Keyword: α2-Adrenoceptor; Author-Supplied Keyword: Calcitonin gene-related peptide; Author-Supplied Keyword: Clonidine; Author-Supplied Keyword: Nitric oxide; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.peptides.2009.06.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Weinstein, Mark
AU - Jain, Nisha
T1 - US regulatory framework for rare plasma protein diseases.
JO - Pharmaceuticals Policy & Law
JF - Pharmaceuticals Policy & Law
Y1 - 2009/09//
VL - 11
IS - 4
M3 - Article
SP - 397
EP - 402
PB - IOS Press
SN - 13892827
AB - FDA encourages the development of products that demonstrate promise for the treatment of rare plasma protein disorders. This is accomplished through a program of regulatory provisions, financial incentives, clinical trials designed to address small patient populations, and measures to increase the number of patients under study. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceuticals Policy & Law is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD protein disorders
KW - FEDERAL aid to medical research
KW - CLINICAL trials
KW - UNITED States
KW - Orphan drug act
KW - rare plasma protein disorders
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 44035040; Weinstein, Mark 1,2,3; Email Address: Mark.Weinstein@FDA.HHS.GOV Jain, Nisha 1,2,3; Affiliation: 1: US Food and Drug Administration, Rockville, MD, USA 2: Center for Biologics Evaluation, Research, Rockville, MD, USA 3: Office of Blood Research and Review, Rockville, MD, USA; Source Info: 2009, Vol. 11 Issue 4, p397; Subject Term: BLOOD protein disorders; Subject Term: FEDERAL aid to medical research; Subject Term: CLINICAL trials; Subject Term: UNITED States; Author-Supplied Keyword: Orphan drug act; Author-Supplied Keyword: rare plasma protein disorders; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.3233/PPL-2009-0241
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Young-Jun Seo
AU - Gi-Hyun Kim
AU - Ho-Jung Kwak
AU - Ju-Sun Nam
AU - Hwa Jeong Lee
AU - Soo-Kyung Suh
AU - Kyung-Min Baek
AU - Yeo-won Sohn
AU - Seung-Hwa Hong
T1 - Validation of a HeLa Mx2/Luc Reporter Cell Line for the Quantification of Human Type I Interferons.
JO - Pharmacology
JF - Pharmacology
Y1 - 2009/09//
VL - 84
IS - 3
M3 - Article
SP - 135
EP - 144
SN - 00317012
AB - Although antiviral assays have been the most widely available biological assays for interferons (IFNs), they are less sensitive and provide considerable interassay variation. In this study, we demonstrate a new reporter cell line, which is based on HeLa cells transfected with a plasmid containing a human Mx2 promoter driving a luciferase (Luc) cDNA. To characterize the specific gene expression profiles induced by interferon alpha, we analyzed the microarray results of interferon response gene expression induced by IFN-α2a or IFN-α2b treatment with HeLa cells. We found that the Mx2 gene increased the most by treatment with both IFN-α2a and IFN-α2b. Based on this result, we designed a reporter cell line, HeLa-Mx2, suitable for determination of IFN-α. HeLa cells were stably transfected with the luciferase gene under the control of Mx2 promoter. The expression of luciferase can be easily measured for luminescence using a 96-well luminometer and has been correlated with the concentration of added IFN and cell density. In the validation results, our reporter cell line had specificity for type I IFN, but the significant effects of a number of other cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-2, IL-5, IL-6 and GM-CSF, or type II interferon (IFN-γ) were not observed. Moreover, the robustness of our cell line is demonstrated by the lack of an effect of the HeLa-Mx2 cell culture’s age on the performance of the reporter gene assay. The reporter gene assay demonstrated reproducible dose-response curves for IFN-α2a in the range of 1–10,000 IU/ml. The 95% confidential limit and total coefficient of variation estimates ranged between 96 and 116 and 10.51% in the reducible range mentioned above, respectively. In conclusion, we established a stable IFN-responsible HeLa-Mx2 cell line, which has advantages with regard to simplicity, selectivity, and reliability over conventional cytopathic effect reduction assays used to quantify IFN-α activity. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIVIRAL agents
KW - INTERFERONS
KW - HELA cells
KW - LUCIFERASES
KW - LYMPHOKINES
KW - GLYCOPROTEINS
KW - HeLa cell line
KW - Interferon-α
KW - Interferon-α
KW - Mx2
KW - Reporter gene assay
KW - Validation
N1 - Accession Number: 44294094; Young-Jun Seo 1 Gi-Hyun Kim 1,2 Ho-Jung Kwak 1 Ju-Sun Nam 1 Hwa Jeong Lee 2 Soo-Kyung Suh 1 Kyung-Min Baek 1 Yeo-won Sohn 1 Seung-Hwa Hong 1; Email Address: shhon8@kfda.go.kr; Affiliation: 1: Advanced Therapy Products Research Division, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration 2: Ewha Womans University, Pharmacy College, Seoul, Republic of Korea; Source Info: 2009, Vol. 84 Issue 3, p135; Subject Term: ANTIVIRAL agents; Subject Term: INTERFERONS; Subject Term: HELA cells; Subject Term: LUCIFERASES; Subject Term: LYMPHOKINES; Subject Term: GLYCOPROTEINS; Author-Supplied Keyword: HeLa cell line; Author-Supplied Keyword: Interferon-α; Author-Supplied Keyword: Interferon-α; Author-Supplied Keyword: Mx2; Author-Supplied Keyword: Reporter gene assay; Author-Supplied Keyword: Validation; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1159/000235158
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Aquilante, Christina L.
AU - Beitelshees, Amber L.
AU - Cavallari, Larisa H.
AU - Lee, Craig R.
AU - Maciejewski, Stephanie
AU - Momary, Kathryn M.
AU - Vardeny, Orly
AU - Zineh, Issam
T1 - Key Articles Relative to Cardiovascular Pharmacogenomics.
JO - Pharmacotherapy
JF - Pharmacotherapy
Y1 - 2009/09//
VL - 29
IS - 9
M3 - Article
SP - 1110
EP - 1151
SN - 02770008
AB - Significant progress has been made in the field of cardiovascular pharmacogenomics over the past 10 years. As a result, important pharmacogenomic literature is now available for most major cardiovascular disease states. In addition, the results of some studies have prompted inclusion of pharmacogenomic information into the package inserts of specific cardiovascular agents such as warfarin. This compilation provides annotated bibliographies of highimpact cardiovascular pharmacogenomics articles. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmacotherapy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACOGENOMICS
KW - CARDIOVASCULAR diseases
KW - PATIENTS
KW - WARFARIN
KW - ANNOTATIONS
KW - THERAPEUTICS
KW - PLACEBOS (Medicine)
KW - cardiovascular disease
KW - pharmacogenetics
KW - pharmacogenomics
N1 - Accession Number: 44088921; Aquilante, Christina L. 1; Email Address: Christina.aquilante@ucdenver.edu Beitelshees, Amber L. 2 Cavallari, Larisa H. 3 Lee, Craig R. 4 Maciejewski, Stephanie 5 Momary, Kathryn M. 6 Vardeny, Orly 7 Zineh, Issam 8; Affiliation: 1: Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, Colorado 2: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 3: Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois 4: Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 5: Cardiac Center of Creighton University, Omaha, Nebraska 6: Department of Pharmacy Practice, Mercer University College of Pharmacy and Health Sciences, Atlanta, Georgia 7: Division of Pharmacy Practice, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin 8: Genomics Group, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration (FDA), Silver Spring, Maryland; Source Info: Sep2009, Vol. 29 Issue 9, p1110; Subject Term: PHARMACOGENOMICS; Subject Term: CARDIOVASCULAR diseases; Subject Term: PATIENTS; Subject Term: WARFARIN; Subject Term: ANNOTATIONS; Subject Term: THERAPEUTICS; Subject Term: PLACEBOS (Medicine); Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: pharmacogenetics; Author-Supplied Keyword: pharmacogenomics; Number of Pages: 42p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lydon, John
AU - Casale, John F.
AU - Hyesuk Kong
AU - Sullivan, Joseph H.
AU - Daughtry, Craig S. T.
AU - Bailey, Bryan
T1 - The Effects of Ambient Solar UV Radiation on Alkaloid Production by Erythroxylum novogranatense var. novogranatense.
JO - Photochemistry & Photobiology
JF - Photochemistry & Photobiology
Y1 - 2009/09//
VL - 85
IS - 5
M3 - Article
SP - 1156
EP - 1161
SN - 00318655
AB - Truxillines are alkaloids produced by Erythroxylum species and are thought to be derived from the UV-driven dimerization of cinnamoylcocaines. This study was conducted to determine the effects of ambient UV radiation on the production of truxillines in Erythroxylum novogranatense var. novogranatense. Field plants were grown under shelters covered with plastic filters that were transparent to UV radiation, filtered UV-B, or both filtered UV-B and UV-A radiation. The treatments had no significant effect on plant biomass or specific leaf weight. Absorption values in the UV-C and UV-A region of acidified-methanol leaf extracts were higher for plants exposed to UV radiation compared to the no UV radiation treatment. There was a trend in decreasing levels of trans-cinnamoylcocaine and a statistically significant decrease in levels of cis-cinnamoylcocaine in the leaves of plants exposed to UV radiation compared to the no UV radiation treatment. Truxilline levels increased in leaves from plants exposed to UV radiation compared to the no UV radiation treatment. Most significantly, the ratio of truxillines to total cinnamoylcocaines in the leaves was affected by UV, increasing with increased UV exposure. The results support the hypothesis that UV radiation is involved in the formation of truxillines from cinnamoylcocaines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ULTRAVIOLET radiation
KW - ALKALOIDS
KW - ERYTHROXYLUM
KW - PLANT biomass
KW - PHOTOCHEMISTRY
N1 - Accession Number: 43993723; Lydon, John 1; Email Address: john.lydon@ars.usda.gov Casale, John F. 2 Hyesuk Kong 3 Sullivan, Joseph H. 4 Daughtry, Craig S. T. 5 Bailey, Bryan 6; Affiliation: 1: U.S. Department of Agriculture, Agricultural Research Service, Sustainable Agricultural Systems Laboratory, Beltsville Agricultural Research Center, Beltsville, MD. 2: U.S. Department of Justice, Drug Enforcement Administration, Special Testing and Research Laboratory, Dulles, VA. 3: Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, MD. 4: Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD. 5: U.S. Department of Agriculture, Agricultural Research Service, Hydrology and Remote Sensing Laboratory, Beltsville Agricultural Research Center, Beltsville, MD. 6: U.S. Department of Agriculture, Agricultural Research Service, Sustainable Perennial Crops Laboratory, Beltsville Agricultural Research Center, Beltsville, MD.; Source Info: Sep2009, Vol. 85 Issue 5, p1156; Subject Term: ULTRAVIOLET radiation; Subject Term: ALKALOIDS; Subject Term: ERYTHROXYLUM; Subject Term: PLANT biomass; Subject Term: PHOTOCHEMISTRY; Number of Pages: 6p; Illustrations: 3 Charts, 4 Graphs; Document Type: Article
L3 - 10.1111/j.1751-1097.2009.00562.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wei Song
AU - Ruder, Avima M.
AU - Liangyuan Hu
AU - Yufeng Li
AU - Rong Ni
AU - Wenshuo Shao
AU - Kaslow, Richard A.
AU - Butler, MaryAnn
AU - Jianming Tang
T1 - Genetic Epidemiology of Glioblastoma Multiforme: Confirmatory and New Findings from Analyses of Human Leukocyte Antigen Alleles and Motifs.
JO - PLoS ONE
JF - PLoS ONE
Y1 - 2009/09//
VL - 4
IS - 9
M3 - Article
SP - 1
EP - 8
PB - Public Library of Science
SN - 19326203
AB - Background: Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM). Methodology/Principal Findings: As an extension of the Upper Midwest Health Study, we have performed HLA genotyping for 149 GBM patients and 149 healthy control subjects from a non-metropolitan population consisting almost exclusively of European Americans. Conditional logistic regression models did not reproduce the association of HLA-B*07 or the B*07-Cw*07 haplotype with GBM. Nonetheless, HLA-A*32, which has previously been shown to predispose GBM patients to a favorable prognosis, was negatively associated with occurrence of GBM (odds ratio = 0.41, p = 0.04 by univariate analysis). Other alleles (A*29, A*30, A*31 and A*33) within the A19 serology group to which A*32 belongs showed inconsistent trends. Sequencingbased HLA-A genotyping established that A*3201 was the single A*32 allele underlying the observed association. Additional evaluation of HLA-A promoter and exon 1 sequences did not detect any unexpected single nucleotide polymorphisms that could suggest differential allelic expression. Further analyses restricted to female GBM cases and controls revealed a second association with a specific HLA-B sequence motif corresponding to Bw4-80Ile (odds ratio = 2.71, p = 0.02). Conclusions/Significance: HLA-A allelic product encoded by A*3201 is likely to be functionally important to GBM. The novel, sex-specific association will require further confirmation in other representative study populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LEUCOCYTES
KW - ANTIGENS
KW - CELL physiology
KW - PROGNOSIS
KW - GLIOBLASTOMA multiforme
KW - EUROPEAN Americans
KW - LOGISTIC regression analysis
N1 - Accession Number: 55980479; Wei Song 1 Ruder, Avima M. 2 Liangyuan Hu 1 Yufeng Li 3 Rong Ni 3 Wenshuo Shao 1 Kaslow, Richard A. 1,3 Butler, MaryAnn 2 Jianming Tang 3; Email Address: jtang@uab.edu; Affiliation: 1: Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America 2: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, United States of America 3: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America; Source Info: 2009, Vol. 4 Issue 9, p1; Subject Term: LEUCOCYTES; Subject Term: ANTIGENS; Subject Term: CELL physiology; Subject Term: PROGNOSIS; Subject Term: GLIOBLASTOMA multiforme; Subject Term: EUROPEAN Americans; Subject Term: LOGISTIC regression analysis; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 4 Charts; Document Type: Article
L3 - 10.1371/journal.pone.0007157
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chia Chu
AU - Lugovtsev, Vladimir
AU - Golding, Hana
AU - Betenbaugh, Michael
AU - Shiloach, Joseph
T1 - Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2009/09//9/1/2009
VL - 106
IS - 35
M3 - Article
SP - 14802
EP - 14807
SN - 00278424
AB - MDCK cells are currently being considered as an alternative to embryonated eggs for influenza virus propagation and hemagglutinin (HA) production intended for vaccine manufacturing. MDCK cells were found suitable for the virus production but their inability to grow in suspension burdens the process of scale up and hence their production capability. Anchorage-dependent MDCK cells were converted to anchorage-independent cells, capable of growing in suspension as a result of transfection with the human siat7e gene (ST6GalNac V). This gene was previously identified as having an important role in cellular adhesion when the transcriptions of genes from anchorage-dependent and anchorage-independent HeLa cells were compared. Unlike the parental MDCK cells, the siatle-expressing cells were capable of growing in shake flasks as suspension cultures, achieving maximum concentration of 7 × 105 cells/mL while keeping close to 100% viability throughout the growth phase. In production experiments, the siat7e-expressing cells were infected with the Influenza B/Victoria/504/2000 strain. It was determined that the cell-derived viruses retained similar antigenic properties as those obtained from egg-derived viruses and their nucleotide sequences were identical. The specific production of hemagglutinin (expressed in hemagglutination units per 106 cells) from the siat7e-expressing cells was approximately 20 times higher than the specific production from the parental MDCK cells. If this suspension process scales up, the production potential of HA from 10 L of siat7e-expressing cells at a concentration of 106 cells/mL would be equivalent to the amount of HA obtained from 10,000 embryonated eggs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INFLUENZA viruses
KW - CELLS
KW - RESPIRATORY infections
KW - HEMAGGLUTININ
KW - ANTIGENS
KW - anchorage-independent
KW - hemagglutinin
KW - sialyltransferase
KW - vaccine
N1 - Accession Number: 44600380; Chia Chu 1,2 Lugovtsev, Vladimir 3 Golding, Hana 3 Betenbaugh, Michael 1 Shiloach, Joseph 2; Email Address: yossi@nih.gov; Affiliation: 1: Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 2: Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health 3: Center for Biologics Evaluation and Research, Food and Drug Administration, 9000 Rockville Pike, Bethesda, MD 20892; Source Info: 9/1/2009, Vol. 106 Issue 35, p14802; Subject Term: INFLUENZA viruses; Subject Term: CELLS; Subject Term: RESPIRATORY infections; Subject Term: HEMAGGLUTININ; Subject Term: ANTIGENS; Author-Supplied Keyword: anchorage-independent; Author-Supplied Keyword: hemagglutinin; Author-Supplied Keyword: sialyltransferase; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 6p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1073/pnas.0905912106
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44600380&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McGuinness, Kevin M.
AU - Perez, Jon T.
AU - Coady, Jeff A.
T1 - Redefining the Mission: The Mercy Model as a Leadership Approach for Public Health Systems and Population-Based Programs.
JO - Public Health Reports
JF - Public Health Reports
Y1 - 2009/09//Sep/Oct2009
VL - 124
IS - 5
M3 - Article
SP - 625
EP - 628
SN - 00333549
AB - In this article the authors discuss the Mercy Model developed and applied by the U.S. Public Health Service (USPHS) Commissioned Corps as a structure to make fast evaluation of health infrastructure and recovery in any large scale disaster. The author state that the Mercy Model is based on the principles that give emphasis on facilitation, leadership and organization to support damaged public health systems. They cite that the model has demonstrated reliability under various circumstances.
KW - DISASTER relief
KW - EMERGENCY management
KW - ASSISTANCE in emergencies
KW - PUBLIC health surveillance
KW - MEDICAL policy
KW - UNITED States
KW - UNITED States. Public Health Service
N1 - Accession Number: 43897338; McGuinness, Kevin M. 1; Email Address: kevinmcg@gwmail.gwu.edu Perez, Jon T. 2 Coady, Jeff A. 3; Affiliation: 1: HealEh Resources and Services Administration, Rockville, MD 2: Indian Health Service, Rockville, MD 3: Centers for Medicare and Medicaid Services, Chicago, IL; Source Info: Sep/Oct2009, Vol. 124 Issue 5, p625; Subject Term: DISASTER relief; Subject Term: EMERGENCY management; Subject Term: ASSISTANCE in emergencies; Subject Term: PUBLIC health surveillance; Subject Term: MEDICAL policy; Subject Term: UNITED States; Company/Entity: UNITED States. Public Health Service; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105165719
T1 - Redefining the mission: the Mercy Model as a leadership approach for public health systems and population-based programs.
AU - McGuinness KM
AU - Perez JT
AU - Coady JA
Y1 - 2009/09//Sep/Oct2009
N1 - Accession Number: 105165719. Language: English. Entry Date: 20100423. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 9716844.
KW - Emergency Medical Services -- Administration
KW - Leadership
KW - Mass Casualty Incidents
KW - Public Health Administration
KW - Humanitarian Aid -- Administration
KW - Emergency Medical Services
KW - Indonesia
KW - International Relations
KW - Management
KW - Climate
KW - United States
KW - United States Public Health Service
SP - 625
EP - 628
JO - Public Health Reports
JF - Public Health Reports
JA - PUBLIC HEALTH REP
VL - 124
IS - 5
PB - Sage Publications Inc.
SN - 0033-3549
AD - Health Resources and Services Administration, Bureau of Clinician Recruitment and Service, Division of Site and Clinician Recruitment, State and Community Initiative Branch, 5600 Fishers Ln., Room 8A-08, Rockville, MD 20857, USA. kevinmcg@gwmail.gwu.edu
U2 - PMID: 19753940.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105165719&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105413808
T1 - Research dissemination and diffusion: translation within science and society.
AU - Kerner JF
AU - Hall KL
Y1 - 2009/09//
N1 - Accession Number: 105413808. Language: English. Entry Date: 20090925. Revision Date: 20150820. Publication Type: Journal Article; tables/charts. Journal Subset: Allied Health; Peer Reviewed; USA. Special Interest: Evidence-Based Practice; Social Work. NLM UID: 9425959.
KW - Diffusion of Innovation
KW - Health Care Delivery
KW - Theory-Practice Relationship
KW - Behavioral Changes
KW - Confusion
KW - Guideline Adherence
KW - Health Policy Studies
KW - Marketing
KW - Nomenclature
KW - Organizational Change
KW - Outcomes Research
KW - Professional Practice, Evidence-Based
KW - Public Sector
KW - Systematic Review -- Utilization
KW - Systems Design
KW - Time Factors
SP - 519
EP - 530
JO - Research on Social Work Practice
JF - Research on Social Work Practice
JA - RES SOC WORK PRACT
VL - 19
IS - 5
CY - Thousand Oaks, California
PB - Sage Publications Inc.
AB - In moving health and social service programs from planning into action, it is essential to understand the extent to which the knowledge gained from research should influence the actions taken by organizations and agencies that provide services (e.g., government, nongovernment organizations [NGOs]). The complexity of the challenges in translating lessons learned from science into different service settings, as well as into public policy, requires a multifaceted approach to accelerate the integration of research with practice. In this paper, the relationship between science and service is examined within the contexts of the scientific, health practice, and policy communities largely from a public sector perspective within the United States.
SN - 1049-7315
AD - Deputy Director for Research Dissemination and Diffusion, Division of Cancer Control and Population Sciences, National Cancer Institute/National Institutes of Health, United States Department of Health and Human Services, 6130 Executive Blvd. EPN 6142, Bethesda, MD 20892; kernerj@mail.nih.gov
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pezzin, Liliana E.
AU - Pollak, Robert A.
AU - Schone, Barbara S.
AD - Medical College of WI
AD - Washington U in St Louis
AD - Agency for Healthcare Research and Quality, Rockville, MD and Georgetown U
T1 - Long-Term Care of the Disabled Elderly: Do Children Increase Caregiving by Spouses?
JO - Review of Economics of the Household
JF - Review of Economics of the Household
Y1 - 2009/09//
VL - 7
IS - 3
SP - 323
EP - 339
SN - 15695239
N1 - Accession Number: 1059506; Keywords: Caregiving; Disabled; Elderly; Family; Geographic Descriptors: U.S.; Geographic Region: Northern America; Publication Type: Journal Article; Update Code: 200909
N2 - Do adult children affect the care elderly parents provide each other? We develop two models in which the anticipated behavior of adult children provides incentives for nondisabled elderly parents to increase care for their disabled spouses. The "demonstration effect" postulates that adult children learn from a parent's example that family caregiving is appropriate behavior. The "punishment effect" postulates that adult children may punish parents who fail to provide spousal care by not providing future care for the nondisabled spouse if and when necessary. Thus, joint children act as a commitment mechanism, increasing the probability that elderly parents will provide care for their disabled spouses. We argue that stepchildren provide weaker incentives for spousal care because the attachment of a stepchild to a stepparent is likely to be weaker than the attachment of children to parents in a traditional nuclear family. Using data from the HRS, we find evidence consistent with the hypothesis that joint children provide stronger incentives than stepchildren for nondisabled elderly parents to provide care for their disabled spouse.
KW - Household Production and Intrahousehold Allocation D13
KW - Analysis of Health Care Markets I11
KW - Economics of the Elderly; Economics of the Handicapped; Non-labor Market Discrimination J14
L3 - http://link.springer.com/journal/volumesAndIssues/11150
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=ecn&AN=1059506&site=ehost-live&scope=site
UR - http://dx.doi.org/10.1007/s11150-009-9057-6
UR - http://link.springer.com/journal/volumesAndIssues/11150
DP - EBSCOhost
DB - ecn
ER -
TY - JOUR
AU - van Laere, Igor
AU - de Wit, Matty
AU - Klazinga, Niek
T1 - Preventing evictions as a potential public health intervention: Characteristics and social medical risk factors of households at risk in Amsterdam.
JO - Scandinavian Journal of Public Health
JF - Scandinavian Journal of Public Health
Y1 - 2009/09//
VL - 37
IS - 7
M3 - Article
SP - 697
EP - 705
SN - 14034948
AB - Aims: The public health problems precipitating evictions are understudied and no systemic data have been collected. We aim to identify the magnitude of evictions and the characteristics and social medical risk factors of households at risk in Amsterdam. This will help inform policies designed to prevent eviction. Methods: In 2003, case workers of housing associations dealing with rent arrears, and case workers of nuisance control care networks, were interviewed and completed questionnaires about households at risk of eviction. Questionnaires included the processes that resulted in eviction and the characteristics and social medical problems of the households involved. Evicted households were compared with non-evicted households. Results: In Amsterdam, over recent years 1,400 evictions, or four per 1,000 dwellings, took place annually. Of 275 households with rent arrears, 132 were evicted. Of 190 nuisance households, 136 were evicted. In both groups, the largest household group were single male tenants between 25 and 44 years. For those reporting rent arrears, social problems were reported in 71%, medical problems in 23%; independent risk factors for eviction were being of Dutch origin (OR 2.38 (1.30-4.36)) and having a drug-addiction problem (OR 3.58 (0.96-13.39)). For the nuisance households, social problems were reported in 46% and medical problems in 82%, while financial difficulties were a risk factor for eviction (OR: 8.04 (1.05-61.7)). Conclusions: In Amsterdam, households at risk of eviction consisted mainly of single (Dutch) men, aged between 25 and 44 years, often with a combination of social and medical problems. Financial difficulties and drug addiction were independent risk factors for eviction. Because of the social medical problems that were prevalent, for prevention practice evictions should be considered both a socioeconomic and a public health problem. Preventing evictions deserves full attention as a potential effective public health intervention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Public Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - HOUSEHOLDS
KW - SOCIAL media
KW - SOCIAL problems
KW - AMSTERDAM (Netherlands)
KW - NETHERLANDS
KW - Addiction
KW - Amsterdam
KW - evictions
KW - nuisance
KW - pathways into homelessness
KW - public health strategies
KW - rent arrears
N1 - Accession Number: 44109406; van Laere, Igor 1; Email Address: ivlaere@ggd.amsterdam.nl de Wit, Matty 1 Klazinga, Niek 1,2; Affiliation: 1: GGD Municipal Public Health Service Amsterdam, Dr Valckenier Outreach Primary Care Practice for the Homeless, 1000 CE Amsterdam, The Netherlands 2: Academic Medical Centre, University of Amsterdam, Department of Social Medicine, Amsterdam, The Netherlands; Source Info: Sep2009, Vol. 37 Issue 7, p697; Subject Term: PUBLIC health; Subject Term: HOUSEHOLDS; Subject Term: SOCIAL media; Subject Term: SOCIAL problems; Subject Term: AMSTERDAM (Netherlands); Subject Term: NETHERLANDS; Author-Supplied Keyword: Addiction; Author-Supplied Keyword: Amsterdam; Author-Supplied Keyword: evictions; Author-Supplied Keyword: nuisance; Author-Supplied Keyword: pathways into homelessness; Author-Supplied Keyword: public health strategies; Author-Supplied Keyword: rent arrears; NAICS/Industry Codes: 814110 Private Households; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1177/1403494809343479
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44109406&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105325969
T1 - Preventing evictions as a potential public health intervention: characteristics and social medical risk factors of households at risk in Amsterdam.
AU - Van Laere I
AU - De Wit M
AU - Klazinga N
Y1 - 2009/09//
N1 - Accession Number: 105325969. Language: English. Entry Date: 20091120. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 100883503.
KW - Homelessness
KW - Housing
KW - Public Health
KW - Public Policy
KW - Adult
KW - Chi Square Test
KW - Confidence Intervals
KW - Female
KW - Fisher's Exact Test
KW - Interviews
KW - Male
KW - Multivariate Analysis
KW - Netherlands
KW - Odds Ratio
KW - Questionnaires
KW - Risk Factors
KW - Substance Abuse
KW - Human
SP - 697
EP - 705
JO - Scandinavian Journal of Public Health
JF - Scandinavian Journal of Public Health
JA - SCAND J PUBLIC HEALTH
VL - 37
IS - 7
PB - Sage Publications, Ltd.
AB - AIMS: The public health problems precipitating evictions are understudied and no systemic data have been collected. We aim to identify the magnitude of evictions and the characteristics and social medical risk factors of households at risk in Amsterdam. This will help inform policies designed to prevent eviction. METHODS: In 2003, case workers of housing associations dealing with rent arrears, and case workers of nuisance control care networks, were interviewed and completed questionnaires about households at risk of eviction. Questionnaires included the processes that resulted in eviction and the characteristics and social medical problems of the households involved. Evicted households were compared with non-evicted households. RESULTS: In Amsterdam, over recent years 1,400 evictions, or four per 1,000 dwellings, took place annually. Of 275 households with rent arrears, 132 were evicted. Of 190 nuisance households, 136 were evicted. In both groups, the largest household group were single male tenants between 25 and 44 years. For those reporting rent arrears, social problems were reported in 71%, medical problems in 23%; independent risk factors for eviction were being of Dutch origin (OR 2.38 (1.30-4.36)) and having a drug-addiction problem (OR 3.58 (0.96-13.39)). For the nuisance households, social problems were reported in 46% and medical problems in 82%, while financial difficulties were a risk factor for eviction (OR: 8.04 (1.05-61.7)). CONCLUSIONS: In Amsterdam, households at risk of eviction consisted mainly of single (Dutch) men, aged between 25 and 44 years, often with a combination of social and medical problems. Financial difficulties and drug addiction were independent risk factors for eviction. Because of the social medical problems that were prevalent, for prevention practice evictions should be considered both a socioeconomic and a public health problem. Preventing evictions deserves full attention as a potential effective public health intervention.
SN - 1403-4948
AD - GGD Municipal Public Health Service Amsterdam, Dr Valckenier Outreach Primary Care Practice for the Homeless, 1000 CE Amsterdam, The Netherlands; ivlaere@ggd.amsterdam.nl, laere@telfort.nl
U2 - PMID: 19666669.
DO - 10.1177/1403494809343479
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105325969&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - van Laere, Igor
AU - de Wit, Matty
AU - Klazinga, Niek
T1 - Preventing evictions as a potential public health intervention: Characteristics and social medical risk factors of households at risk in Amsterdam.
JO - Scandinavian Journal of Public Health
JF - Scandinavian Journal of Public Health
Y1 - 2009/09//
VL - 37
IS - 7
M3 - Article
SP - 697
EP - 705
SN - 14034948
AB - Aims: The public health problems precipitating evictions are understudied and no systemic data have been collected. We aim to identify the magnitude of evictions and the characteristics and social medical risk factors of households at risk in Amsterdam. This will help inform policies designed to prevent eviction. Methods: In 2003, case workers of housing associations dealing with rent arrears, and case workers of nuisance control care networks, were interviewed and completed questionnaires about households at risk of eviction. Questionnaires included the processes that resulted in eviction and the characteristics and social medical problems of the households involved. Evicted households were compared with non-evicted households. Results: In Amsterdam, over recent years 1,400 evictions, or four per 1,000 dwellings, took place annually. Of 275 households with rent arrears, 132 were evicted. Of 190 nuisance households, 136 were evicted. In both groups, the largest household group were single male tenants between 25 and 44 years. For those reporting rent arrears, social problems were reported in 71%, medical problems in 23%; independent risk factors for eviction were being of Dutch origin (OR 2.38 (1.30-4.36)) and having a drug-addiction problem (OR 3.58 (0.96-13.39)). For the nuisance households, social problems were reported in 46% and medical problems in 82%, while financial difficulties were a risk factor for eviction (OR: 8.04 (1.05-61.7)). Conclusions: In Amsterdam, households at risk of eviction consisted mainly of single (Dutch) men, aged between 25 and 44 years, often with a combination of social and medical problems. Financial difficulties and drug addiction were independent risk factors for eviction. Because of the social medical problems that were prevalent, for prevention practice evictions should be considered both a socioeconomic and a public health problem. Preventing evictions deserves full attention as a potential effective public health intervention. [ABSTRACT FROM AUTHOR]
AB - Copyright of Scandinavian Journal of Public Health is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC health
KW - HOUSEHOLDS
KW - SOCIAL media
KW - SOCIAL problems
KW - AMSTERDAM (Netherlands)
KW - NETHERLANDS
KW - Addiction
KW - Amsterdam
KW - evictions
KW - nuisance
KW - pathways into homelessness
KW - public health strategies
KW - rent arrears
N1 - Accession Number: 44109406; van Laere, Igor 1; Email Address: ivlaere@ggd.amsterdam.nl; de Wit, Matty 1; Klazinga, Niek 1,2; Source Information: Sep2009, Vol. 37 Issue 7, p697; Subject: PUBLIC health; Subject: HOUSEHOLDS; Subject: SOCIAL media; Subject: SOCIAL problems; Geographic Terms: AMSTERDAM (Netherlands); NETHERLANDS; Author-Supplied Keyword: Addiction; Author-Supplied Keyword: Amsterdam; Author-Supplied Keyword: evictions; Author-Supplied Keyword: nuisance; Author-Supplied Keyword: pathways into homelessness; Author-Supplied Keyword: public health strategies; Author-Supplied Keyword: rent arrears; Number of Pages: 9p; Illustrations: 1 Diagram, 3 Charts; Document Type: Article
L3 - 10.1177/1403494809343479
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DP - EBSCOhost
DB - hch
ER -
TY - NEWS
AU - Thompson, Aliza M.
AU - Oliver, Juan A.
T1 - Endogenous and Exogenous Vasopressin during Hemodialysis.
JO - Seminars in Dialysis
JF - Seminars in Dialysis
Y1 - 2009/09//Sep/Oct2009
VL - 22
IS - 5
M3 - Editorial
SP - 472
EP - 475
PB - Wiley-Blackwell
SN - 08940959
AB - Intradialytic hypotension likely results from hypovolemia as well as patient and dialysis-specific factors. An impaired vasoconstrictive response to volume loss during hemodialysis has been demonstrated and increasing evidence suggests that deficiency in the hormone arginine vasopressin may be a contributing factor. Although vasopressin is widely recognized for its role in the regulation of serum osmolality, vasopressin is also an important regulator of blood pressure in health and in various disease states. That vasopressin deficiency contributes to the pathogenesis of intradialytic hypotension is suggested by several observations. First, vasopressin levels typically fall during hemodialysis when a rise might be expected as a result of volume loss. Second, therapies that prevent a fall in osmolality during dialysis, including dialysis against a high sodium bath and isolated ultrafiltration, have been shown to improve intradialytic blood pressure stability. Finally, and perhaps most importantly, the administration of low-dose exogenous vasopressin during dialysis has been shown to support blood pressure and improve volume removal. Further research is needed to determine the effect of chronic vasopressin (or selective V1a agonist) administration during dialysis on volume removal, inter- and intradialytic blood pressure control, and, ultimately, clinical outcomes in end-stage renal disease patients on dialysis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Seminars in Dialysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VASOPRESSIN
KW - HEMODIALYSIS
KW - HYPOTENSION
KW - BLOOD pressure
KW - HEMODIALYSIS patients
KW - KIDNEY diseases -- Treatment
N1 - Accession Number: 44579167; Thompson, Aliza M. 1 Oliver, Juan A. 2; Email Address: jao7@columbia.edu; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 2: Department of Medicine, Columbia University, New York, New York; Source Info: Sep/Oct2009, Vol. 22 Issue 5, p472; Subject Term: VASOPRESSIN; Subject Term: HEMODIALYSIS; Subject Term: HYPOTENSION; Subject Term: BLOOD pressure; Subject Term: HEMODIALYSIS patients; Subject Term: KIDNEY diseases -- Treatment; NAICS/Industry Codes: 621492 Kidney Dialysis Centers; Number of Pages: 4p; Illustrations: 2 Graphs; Document Type: Editorial
L3 - 10.1111/j.1525-139X.2009.00615.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105232408
T1 - Endogenous and Exogenous Vasopressin during Hemodialysis.
AU - Thompson AM
AU - Oliver JA
Y1 - 2009/09//Sep/Oct2009
N1 - Accession Number: 105232408. Language: English. Entry Date: 20100730. Revision Date: 20150711. Publication Type: Journal Article; editorial. Journal Subset: Biomedical; USA. NLM UID: 8911629.
KW - Hypotension -- Drug Therapy
KW - Hypotension -- Etiology
KW - Hemodialysis
KW - Vasopressins -- Physiology
KW - Vasopressins -- Therapeutic Use
KW - Vasopressins -- Deficiency
SP - 472
EP - 475
JO - Seminars in Dialysis
JF - Seminars in Dialysis
JA - SEMIN DIALYSIS
VL - 22
IS - 5
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0894-0959
AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
U2 - PMID: 19522759.
DO - 10.1111/j.1525-139X.2009.00615.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Cha-oncin Sooksriwong
AU - Yoongthong, Worasuda
AU - Suwattanapreeda, Siriwat
AU - Chanjaruporn, Farsai
T1 - Medicine prices in Thailand: A result of no medicine pricing policy.
JO - Southern Med Review
JF - Southern Med Review
Y1 - 2009/09//
VL - 2
IS - 2
M3 - Article
SP - 10
EP - 14
SN - 11742704
AB - Objectives: The main goal of this study was to document the situation of medicine prices in public and private health sectors for policy recommendation. Methods: A field study to measure prices of selected medicines was undertaken in Thailand using a standardized methodology developed by the World Health Organization (WHO) and Health Action International (HAI). Prices of 43 medicines were measured in health facilities and pharmacies in the capital city and three districts in different parts of Thailand. Medicine prices were expressed as the ratios relative to a standard set of international reference prices (median price ratio or MPR). Results: The public sector procured generics and innovator brands at 1.46 and 3.3 MPR while patients paid 2.55 and 4.36 MPR, respectively. Private pharmacies procured lowest price generics at 1.48 MPR and innovator brands at 9.67 MPR. Because of no medicine pricing policy in Thailand, it was found that between public and private sectors, among different public hospitals, and among different private pharmacies, the same generic products were procured and sold to patients at different prices. The median mark-up for innovator brands were 31% in the public sector and 22% in the private sector. For lowest priced generics, the median mark-up were 80% in the public sector and 96% in the private sector. Different prices for the identical product were problems to the health insurance organizations in terms of reimbursement, and to patients in terms of fairness. Conclusion: The results highlight priority areas for action by the Ministry of Public Health and others in improving the drug pricing systems. The price regulation system should be implemented at every level of drug supply chain and appropriate pricing strategies should be employed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Southern Med Review is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICINE
KW - PRICES
KW - MANAGEMENT science
KW - DRUGSTORES
KW - THERAPEUTICS
KW - PUBLIC health
KW - METHODOLOGY
KW - THAILAND
KW - medicine price policy
KW - Medicine pricing
KW - Thailand
KW - WORLD Health Organization
N1 - Accession Number: 43938671; Cha-oncin Sooksriwong 1; Email Address: pycss@mahidol.ac.th Yoongthong, Worasuda 2 Suwattanapreeda, Siriwat 1 Chanjaruporn, Farsai 2; Affiliation: 1: Social and Administrative Pharmacy Excellence Research Unit, Faculty of Pharmacy, Mahidol University, Thailand 2: Drug Control Division, The Office of Food and Drug Administration, Ministry of Public Health, Thailand; Source Info: Sep2009, Vol. 2 Issue 2, p10; Subject Term: MEDICINE; Subject Term: PRICES; Subject Term: MANAGEMENT science; Subject Term: DRUGSTORES; Subject Term: THERAPEUTICS; Subject Term: PUBLIC health; Subject Term: METHODOLOGY; Subject Term: THAILAND; Author-Supplied Keyword: medicine price policy; Author-Supplied Keyword: Medicine pricing; Author-Supplied Keyword: Thailand; Company/Entity: WORLD Health Organization; NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Samuel M.
AU - Storer, Richard D.
AU - Criswell, Kay A.
AU - Doerrer, Nancy G.
AU - Dellarco, Vicki L.
AU - Pegg, David G.
AU - Wojcinski, Zbigniew W.
AU - Malarkey, David E.
AU - Jacobs, Abigail C.
AU - Klaunig, James E.
AU - Swenberg, James A.
AU - Cook, Jon C.
T1 - Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2009/09//
VL - 111
IS - 1
M3 - Article
SP - 4
EP - 18
SN - 10966080
AB - Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including industrial, agricultural, and pharmaceutical agents. Spontaneous HS arise frequently in mice, less commonly in rats, and frequently in numerous breeds of dogs. This review explores knowledge gaps and uncertainties related to the mode of action (MOA) for the induction of HS in rodents, and evaluates the potential relevance for human risk. For genotoxic chemicals (vinyl chloride and thorotrast), significant information is available concerning the MOA. In contrast, numerous chemicals produce HS in rodents by nongenotoxic, proliferative mechanisms. An overall framework is presented, including direct and indirect actions on endothelial cells, paracrine effects in local tissues, activation of bone marrow endothelial precursor cells, and tissue hypoxia. Numerous obstacles are identified in investigations into the MOA for mouse HS and the relevance of the mouse tumors to humans, including lack of identifiable precursor lesions, usually late occurrence of the tumors, and complexities of endothelial biology. This review proposes a working MOA for HS induced by nongenotoxic compounds that can guide future research in this area. Importantly, a common MOA appears to exist for the nongenotoxic induction of HS, where there appears to be a convergence of multiple initiating events (e.g., hemolysis, decreased respiration, adipocyte growth) leading to either dysregulated angiogenesis and/or erythropoiesis that results from hypoxia and macrophage activation. These later events lead to the release of angiogenic growth factors and cytokines that stimulate endothelial cell proliferation, which, if sustained, provide the milieu that can lead to HS formation. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANGIOSARCOMA
KW - CYTOKINES
KW - ENDOTHELIUM
KW - TUMORS
KW - NEOVASCULARIZATION
KW - angiogenesis
KW - endothelial cells
KW - endothelial precursor cells
KW - hemangiosarcoma
KW - human relevance
KW - mode of action
KW - PPAR agonists
N1 - Accession Number: 44355946; Cohen, Samuel M. 1 Storer, Richard D. 2 Criswell, Kay A. 3 Doerrer, Nancy G. 4; Email Address: ndoerrer@hesiglobal.org Dellarco, Vicki L. 5 Pegg, David G. 6 Wojcinski, Zbigniew W. 7 Malarkey, David E. 8 Jacobs, Abigail C. 9 Klaunig, James E. 10 Swenberg, James A. 11 Cook, Jon C. 3; Affiliation: 1: University of Nebraska Medical Center, Omaha, Nebraska 68198 2: Merck Research Laboratories, West Point, Pennsylvania 19486 3: Pfizer, Inc., Groton, Connecticut 06340 4: ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5: United States Environmental Protection Agency, Washington, DC 20460 6: Michigan Technology and Research Institute, Ann Arbor, Michigan 48104 7: Fulcrum Pharma Developments, Inc., Ann Arbor, Michigan 48103 8: National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709 9: United States Food and Drug Administration, Silver Spring, Maryland 20993 10: Indiana University School of Medicine, Indianapolis, Indiana 46202 11: University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599; Source Info: Sep2009, Vol. 111 Issue 1, p4; Subject Term: ANGIOSARCOMA; Subject Term: CYTOKINES; Subject Term: ENDOTHELIUM; Subject Term: TUMORS; Subject Term: NEOVASCULARIZATION; Author-Supplied Keyword: angiogenesis; Author-Supplied Keyword: endothelial cells; Author-Supplied Keyword: endothelial precursor cells; Author-Supplied Keyword: hemangiosarcoma; Author-Supplied Keyword: human relevance; Author-Supplied Keyword: mode of action; Author-Supplied Keyword: PPAR agonists; Number of Pages: 15p; Illustrations: 2 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1093/toxsci/kfp131
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Gopee, Neera V.
AU - Roberts, Dean W.
AU - Webb, Peggy
AU - Cozart, Christy R.
AU - Siitonen, Paul H.
AU - Latendresse, John R.
AU - Warbitton, Alan R.
AU - Yu, William W.
AU - Colvin, Vicki L.
AU - Walker, Nigel J.
AU - Howard, Paul C.
T1 - Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2009/09//
VL - 111
IS - 1
M3 - Article
SP - 37
EP - 48
SN - 10966080
AB - Many cosmetics, sunscreens, and other consumer products are reported to contain nanoscale materials. The possible transdermal absorption of nanoscale materials and the long-term consequences of the absorption have not been determined. We used polyethylene glycol coated cadmium selenide (CdSe) core quantum dots (QD; 37 nm diameter) to evaluate the penetration of nanoscale material into intact, tape stripped, acetone treated, or dermabraded mouse skin. QD were suspended in an oil-in-water emulsion (approximately 9μM) and the emulsion was applied at 2 mg/cm2 to mouse dorsal skin pretreated as follows: intact; tape stripped to remove the stratum corneum; acetone pretreated; dermabraded to remove stratum corneum and epidermis. QD penetration into the skin was monitored in sentinel organs (liver and regional draining lymph nodes) using inductively coupled plasma mass spectrometry analysis of cadmium (from the CdSe QD). No consistent cadmium elevation was detected in the sentinel organs of mice with intact, acetone pretreated, or tape-stripped skin at 24- and 48-h post-QD application; however, in dermabraded mice, cadmium elevations were detected in the lymph nodes and liver. QD accumulation (as cadmium) in the liver was approximately 2.0% of the applied dose. The passing of QD through the dermabraded skin was confirmed using confocal fluorescence microscopy. These results suggest that transdermal absorption of nanoscale materials depends on skin barrier quality, and that the lack of an epidermis provided access to QD penetration. Future dermal risk assessments of nanoscale materials should consider key barrier aspects of skin and its overall physiologic integrity. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COSMETICS
KW - NANOSTRUCTURED materials
KW - ABSORPTION
KW - POLYETHYLENE glycol
KW - CADMIUM selenide
KW - dermabrasion
KW - nanoscale materials
KW - quantum dots
N1 - Accession Number: 44355936; Gopee, Neera V. 1,2 Roberts, Dean W. 1,2 Webb, Peggy 1,2 Cozart, Christy R. 1 Siitonen, Paul H. 1 Latendresse, John R. 3 Warbitton, Alan R. 3 Yu, William W. 4 Colvin, Vicki L. 4 Walker, Nigel J. 5 Howard, Paul C. 1,2; Email Address: Paul.Howard@fda.hhs.gov; Affiliation: 1: National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, Arkansas 72079 2: National Toxicology Program Center for Phototoxicology, U.S. Food & Drug Administration, Jefferson, Arkansas 72079 3: Toxicology Pathology Associates, Jefferson, Arkansas 72079 4: Center for Biological and Environmental Nanotechnology, Rice University, Houston, Texas 77005 5: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; Source Info: Sep2009, Vol. 111 Issue 1, p37; Subject Term: COSMETICS; Subject Term: NANOSTRUCTURED materials; Subject Term: ABSORPTION; Subject Term: POLYETHYLENE glycol; Subject Term: CADMIUM selenide; Author-Supplied Keyword: dermabrasion; Author-Supplied Keyword: nanoscale materials; Author-Supplied Keyword: quantum dots; NAICS/Industry Codes: 325620 Toilet Preparation Manufacturing; NAICS/Industry Codes: 414520 Toiletries, cosmetics and sundries merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 446120 Cosmetics, Beauty Supplies, and Perfume Stores; Number of Pages: 12p; Illustrations: 5 Diagrams, 3 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfp139
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fang, Jia-Long
AU - Beland, Frederick A.
T1 - Long-Term Exposure to Zidovudine Delays Cell Cycle Progression, Induces Apoptosis, and Decreases Telomerase Activity in Human Hepatocytes.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2009/09//
VL - 111
IS - 1
M3 - Article
SP - 120
EP - 130
SN - 10966080
AB - Zidovudine (3′-azido-3′-deoxythymidine; AZT), which is currently used in the treatment of acquired immunodeficiency syndrome, has been shown to have anticancer properties. In the present study, we examined the mechanisms contributing to increased sensitivity of cancer cells to the growth-inhibitory effects of AZT. This was accomplished by incubating a hepatoma cell line (HepG2) and a normal liver cell line (THLE2) with AZT in continuous culture for up to 4 weeks and evaluating the number of viable and necrotic cells, the induction of apoptosis, cell cycle alterations, and telomerase activity. In HepG2 cells, AZT (2–100μM) caused significant dose-dependent decreases in the number of viable cells at exposures > 24 h. During a 1-week recover period, there was only a slight increase in the number of viable cells treated with AZT. The decrease in viable cells was associated with an induction of apoptosis, a decrease in telomerase activity, and S and G2/M phase arrest of the cell cycle. During the recovery period, the extent of apoptosis and telomerase activity returned to control levels, whereas the disruption of cell cycle progression persisted. Western blot analysis indicated that AZT caused a decrease in checkpoint kinase 1 (Chk1) and kinase 2 (Chk2) and an increase in phosphorylated Chk1 (Ser345) and Chk2 (Thr68). Similar effects, to lesser extent, were observed in THLE2 cells given much higher concentrations of AZT (50–2500μM). These data show that HepG2 cells are much more sensitive than THLE2 cells to AZT. They also indicate that a combination of a delay of cell cycle progression, an induction of apoptosis, and a decrease in telomerase activity is contributing to the decrease in the number of viable cells from AZT treatment, and that checkpoint enzymes Chk1 and Chk2 may play an important role in the delay of cell cycle progression. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AZT (Drug)
KW - AIDS (Disease)
KW - ANTIRETROVIRAL agents
KW - PROTEIN kinases
KW - APOPTOSIS
KW - apoptosis
KW - AZT
KW - cell cycle
KW - checkpoint kinases
KW - telomerase activity
N1 - Accession Number: 44355933; Fang, Jia-Long 1; Email Address: jia-long.fang@fda.hhs.gov Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079; Source Info: Sep2009, Vol. 111 Issue 1, p120; Subject Term: AZT (Drug); Subject Term: AIDS (Disease); Subject Term: ANTIRETROVIRAL agents; Subject Term: PROTEIN kinases; Subject Term: APOPTOSIS; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: AZT; Author-Supplied Keyword: cell cycle; Author-Supplied Keyword: checkpoint kinases; Author-Supplied Keyword: telomerase activity; Number of Pages: 11p; Illustrations: 1 Diagram, 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfp136
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Jerome P.
AU - Martin, Aaron
AU - Sammons, Deborah L.
AU - Striley, Cynthia
AU - Biagini, Raymond
AU - Quinn, John
AU - Cope, Rick
AU - Snawder, John E.
T1 - Measurement of methamphetamine on surfaces using surface plasmon resonance.
JO - Toxicology Mechanisms & Methods
JF - Toxicology Mechanisms & Methods
Y1 - 2009/09//Jul-Sep2009
VL - 19
IS - 6-7
M3 - Article
SP - 416
EP - 421
PB - Taylor & Francis Ltd
SN - 15376516
AB - Field methods are needed to assess the contamination of surfaces by methamphetamine from illicit drug manufacturing. This study performed a feasibility study on the use of a surface plasmon resonance (SPR) based instrument (SensiQ Discovery) in the evaluation of surface contamination by methamphetamine. The main goal was to see if the method could be sensitive enough for field measurements. A competitive immunochemical assay was developed for the instrument which was able to measure methamphetamine at 9 ng/ml with a range of 9–250 ng/ml. Methamphetamine was spiked onto ceramic tiles and the assay was able to detect methamphetamine contamination at 25 ng/100 cm2, which is below the 50 ng/100 cm2 standard used for surface cleanup assessment. The instrument is compact and mobile and is sensitive enough for use for measurement of methamphetamine on surfaces, so it is a candidate for a field method for methamphetamine surface contamination. Its use for this application will require further development of the instrument to make it more convenient to use. Also further evaluation of ruggedness and use of the instrument under various environmental conditions such as temperature and humidity are needed to define conditions under which the instrument can be employed in field measurements. [ABSTRACT FROM AUTHOR]
AB - Copyright of Toxicology Mechanisms & Methods is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - METHAMPHETAMINE
KW - SURFACE plasmon resonance
KW - OPTICAL detectors
KW - BIOSENSORS
KW - AMPHETAMINES
KW - Competitive immunoassay
KW - methamphetamine surface measurement
KW - surface plasmon resonance (SPR)
N1 - Accession Number: 44090462; Smith, Jerome P. 1; Email Address: jps3@cdc.gov Martin, Aaron 2 Sammons, Deborah L. 1 Striley, Cynthia 1 Biagini, Raymond 1 Quinn, John 2 Cope, Rick 2 Snawder, John E. 1; Affiliation: 1: Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. 2: ICX Nomadics, Oklahoma City, Oklahoma, USA.; Source Info: Jul-Sep2009, Vol. 19 Issue 6-7, p416; Subject Term: METHAMPHETAMINE; Subject Term: SURFACE plasmon resonance; Subject Term: OPTICAL detectors; Subject Term: BIOSENSORS; Subject Term: AMPHETAMINES; Author-Supplied Keyword: Competitive immunoassay; Author-Supplied Keyword: methamphetamine surface measurement; Author-Supplied Keyword: surface plasmon resonance (SPR); NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; Number of Pages: 6p; Illustrations: 2 Diagrams, 1 Chart, 4 Graphs; Document Type: Article
L3 - 10.1080/15376510903114959
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Costa, Pedro Reis
AU - Baugh, Keri A.
AU - Wright, Bruce
AU - RaLonde, Raymond
AU - Nance, Shelly L.
AU - Tatarenkova, Natália
AU - Etheridge, Stacey M.
AU - Lefebvre, Kathi A.
T1 - Comparative determination of paralytic shellfish toxins (PSTs) using five different toxin detection methods in shellfish species collected in the Aleutian Islands, Alaska
JO - Toxicon
JF - Toxicon
Y1 - 2009/09//
VL - 54
IS - 3
M3 - Article
SP - 313
EP - 320
SN - 00410101
AB - Abstract: Paralytic shellfish poisoning (PSP), a human illness caused by the ingestion of shellfish contaminated with paralytic shellfish toxins (PSTs), has been reported in Alaska for decades. These poisoning incidents have resulted in losses to local economies due to shellfish harvest closures. Thus the development of an effective biotoxin monitoring program designed specifically for the remote regions of Alaska would provide protection for public health and allow for a viable shellfish industry. The present study provides data useful for the development of an effective toxin screening protocol by comparing PST levels quantified in shellfish by many of the currently available PST detection techniques. Seven bivalve species were collected along beaches of the Aleutian Islands from June 2006 to September 2007. The concentration of PSTs was quantified and compared using five different analytical methods: the mouse bioassay, high performance liquid chromatography (HPLC), receptor-binding assay, the commercially available Jellett Rapid PSP Test strips, and an enzyme linked immunosorbent assay technique. The Association of Official Analytical Chemists (AOAC)-approved HPLC method proved to be valuable for characterizing the suite of individual PSTs in each species for research purposes, but was not considered practical for rapid toxin screening in remote Alaskan regions due to its time-consuming nature and requirement of expensive equipment and considerable expertise. In the present study, Jellett test strips were shown to be an effective tool for rapid screening, however due to the high percentage of false positives, subsequent validation via AOAC-approved methods would be required to prevent unnecessary closures. [Copyright &y& Elsevier]
AB - Copyright of Toxicon is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SAXITOXIN
KW - POISONS -- Analysis
KW - SHELLFISH
KW - DISEASES
KW - PARALYTIC shellfish poisoning
KW - PUBLIC health
KW - BIOLOGICAL assay
KW - HIGH performance liquid chromatography
KW - ALEUTIAN Islands (Alaska)
KW - ALASKA
KW - Paralytic shellfish poisoning
KW - Paralytic shellfish toxins
KW - Saxitoxin
N1 - Accession Number: 43030877; Costa, Pedro Reis 1 Baugh, Keri A. 1 Wright, Bruce 2 RaLonde, Raymond 3 Nance, Shelly L. 1 Tatarenkova, Natália 2 Etheridge, Stacey M. 4 Lefebvre, Kathi A. 1; Email Address: kathi.lefebvre@noaa.gov; Affiliation: 1: NOAA Fisheries, Northwest Fisheries Science Center, Marine Biotoxins Program, 2725 Montlake Blvd. East, Seattle, WA 98112, USA 2: Aleutian Pribilof Islands Association, 1131 E. International Road, Anchorage, AK 99518, USA 3: Alaska Sea Grant Marine Advisory Program, 1007 W. 3rd Ave. #100, Anchorage, AK 99501, USA 4: US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740, USA; Source Info: Sep2009, Vol. 54 Issue 3, p313; Subject Term: SAXITOXIN; Subject Term: POISONS -- Analysis; Subject Term: SHELLFISH; Subject Term: DISEASES; Subject Term: PARALYTIC shellfish poisoning; Subject Term: PUBLIC health; Subject Term: BIOLOGICAL assay; Subject Term: HIGH performance liquid chromatography; Subject Term: ALEUTIAN Islands (Alaska); Subject Term: ALASKA; Author-Supplied Keyword: Paralytic shellfish poisoning; Author-Supplied Keyword: Paralytic shellfish toxins; Author-Supplied Keyword: Saxitoxin; NAICS/Industry Codes: 525120 Health and Welfare Funds; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 114114 Freshwater fishing; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.toxicon.2009.04.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43030877&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105263097
T1 - Occupational hazards experienced by cleaning workers and janitors: a review of the epidemiologic literature.
AU - Charles LE
AU - Loomis D
AU - Demissie Z
Y1 - 2009/09//
N1 - Accession Number: 105263097. Language: English. Entry Date: 20091016. Revision Date: 20150819. Publication Type: Journal Article; research; systematic review; tables/charts. Journal Subset: Allied Health; Europe; Peer Reviewed; UK & Ireland. Special Interest: Evidence-Based Practice; Occupational Therapy. NLM UID: 9204382.
KW - Occupational Exposure
KW - Occupational Hazards
KW - Workforce
KW - Communicable Diseases -- Epidemiology
KW - Confidence Intervals
KW - Descriptive Statistics
KW - Hypersensitivity -- Epidemiology
KW - Musculoskeletal System -- Pathology
KW - Relative Risk
KW - Skin Diseases -- Epidemiology
KW - Systematic Review
SP - 105
EP - 116
JO - Work
JF - Work
JA - WORK
VL - 34
IS - 1
PB - IOS Press
AB - Building cleaners are an important group of workers who experience diverse occupational hazards resulting in health problems. A review of epidemiologic studies conducted between 1981 and 2005 was performed using PubMed and PsychLit, to identify health outcomes and the associated hazards in the work environment of cleaners. Among 35 studies, respiratory diseases (n=17) and dermatologic diseases (n=9) were the most common and were associated with exposure to cleaning agents, wet work, and rubber latex. The potential for infectious diseases (n=3) was identified among cleaners in medical laboratories and was associated with exposure to broken glass and uncapped needles in the trash. Musculoskeletal disorders (n=5) were associated with several physical stressors (e.g., awkward postures, prolonged standing) and psychosocial stressors (e.g., monotonous job, low potential for promotion). Mental disorders (n=1) were also associated with psychosocial stressors and societal stigma. Future studies may be enhanced by better assessment of the specific job exposures of cleaners and implementation of a prospective design.
SN - 1051-9815
AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505-2845, USA. lcharles@cdc.gov
U2 - PMID: 19923681.
DO - 10.3233/WOR-2009-0907
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105263097&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-17579-001
AN - 2009-17579-001
AU - Lidz, Charles W.
AU - Appelbaum, Paul S.
AU - Joffe, Steven
AU - Albert, Karen
AU - Rosenbaum, Jill
AU - Simon, Lorna
T1 - Competing commitments in clinical trials.
JF - IRB: Ethics & Human Research
JO - IRB: Ethics & Human Research
JA - IRB
Y1 - 2009/09//Sep-Oct, 2009
VL - 31
IS - 5
SP - 1
EP - 6
CY - US
PB - Hastings Ctr
SN - 0193-7758
SN - 2326-2222
N1 - Accession Number: 2009-17579-001. Other Journal Title: IRB: A Review of Human Subjects Research. Partial author list: First Author & Affiliation: Lidz, Charles W.; Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester, MA, US. Release Date: 20100405. Correction Date: 20150518. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Clinical Trials; Clinicians; Experimental Ethics; Role Conflicts. Classification: Professional Ethics & Standards & Liability (3450); Human Experimental Psychology (2300). Population: Human (10); Male (30); Female (40). Age Group: Adulthood (18 yrs & older) (300); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Sep-Oct, 2009.
AB - Scholars of the ethics of clinical trials have long recognized a tension between the therapeutic obligations of clinicians and the scientific demands of clinical trials. The basis for this concern is clear: clinical care is focused on improving the condition of the presenting patient, while clinical research seeks valid, generalizable information to help future patients. We used Centerwatch.com, an online listing of over 30,000 clinical trials that, at the time of the survey, was the largest listing of active clinical trials, to obtain a sample of individuals to invite to participate in our study. 741 respondents (46% were nurses and 20% were physicians) completed in-depth interviews. Survey findings raise questions about the impact of decisions grounded in clinical commitments on the validity of data derived from clinical trials. Most of the respondents admitted they are aware of selection biases and explicit deviations during the recruitment process and of protocol violations due to what they perceive to be the best medical interests of their patients. This finding suggests that conflicts between therapeutic obligations and the scientific demands of clinical trials may adversely influence the validity of findings from clinical trials. Thus, there is a need for additional data on the prevalence of protocol deviations, the causal role that clinical imperatives play in prompting these behaviors, and especially the impact of such behaviors on clinical trial results. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - therapeutic obligations
KW - clinicians
KW - scientific demands
KW - competing commitments
KW - clinical trials
KW - ethics
KW - 2009
KW - Clinical Trials
KW - Clinicians
KW - Experimental Ethics
KW - Role Conflicts
KW - 2009
U1 - Sponsor: National Institute of Neurological Disorders and Stroke, US. Grant: NS049595. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17579-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-16814-002
AN - 2009-16814-002
AU - Miller, Victoria A.
AU - Reynolds, William W.
AU - Ittenbach, Richard F.
AU - Luce, Mary Frances
AU - Beauchamp, Tom L.
AU - Nelson, Robert M.
T1 - Challenges in measuring a new construct: Perception of voluntariness for research and treatment decision making.
JF - Journal of Empirical Research on Human Research Ethics
JO - Journal of Empirical Research on Human Research Ethics
JA - J Empir Res Hum Res Ethics
Y1 - 2009/09//
VL - 4
IS - 3
SP - 21
EP - 31
CY - US
PB - University of California Press
SN - 1556-2646
SN - 1556-2654
AD - Miller, Victoria A., Children’s Hospital of Philadelphia, 34th St. and Civic Center Blvd., CHOP North Room 1515, Philadelphia, PA, US, 19104
N1 - Accession Number: 2009-16814-002. PMID: 19754231 Partial author list: First Author & Affiliation: Miller, Victoria A.; Children’s Hospital of Philadelphia, Philadelphia, PA, US. Other Publishers: Sage Publications. Release Date: 20100315. Correction Date: 20141124. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Luce, Mary Frances. Major Descriptor: Experimental Subjects; Experimentation; Methodology; Test Construction. Classification: Research Methods & Experimental Design (2260); Professional Ethics & Standards & Liability (3450). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). References Available: Y. Page Count: 11. Issue Publication Date: Sep, 2009. Publication History: Revised Date: Jul 13, 2009; First Submitted Date: Jun 15, 2009. Copyright Statement: All rights reserved. Joan Sieber. 2009.
AB - Reliable and valid measures of relevant constructs are critical in the developing field of the empirical study of research ethics. The early phases of scale development for such constructs can be complex. We describe the methodological challenges of construct definition and operationalization and how we addressed them in our study to develop a measure of perception of voluntariness. We also briefly present our conceptual approach to the construct of voluntariness, which we defined as the perception of control over decision making. Our multifaceted approach to scale development ensured that we would develop a construct definition of sufficient breadth and depth, that our new measure of voluntariness would be applicable across disciplines, and that there was a clear link between our construct definition and items. The strategies discussed here can be adapted by other researchers who are considering a scale development study related to the empirical study of ethics. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - measurement
KW - test construction
KW - perception of voluntariness
KW - methodological challenges
KW - 2009
KW - Experimental Subjects
KW - Experimentation
KW - Methodology
KW - Test Construction
KW - 2009
U1 - Sponsor: National Science Foundation. Grant: SES-0527618. Recipients: Luce, Mary Frances; Beauchamp, Tom L.; Nelson, Robert M.
U1 - Sponsor: National Institutes of Health, National Cancer Institute, US. Grant: R21CA118377-01A. Recipients: Nelson, Robert M.
U1 - Sponsor: Children’s Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, US. Other Details: Institutional Development Grant, Center for Research Integrity. Recipients: No recipient indicated
DO - 10.1525/jer.2009.4.3.21
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-16814-002&site=ehost-live&scope=site
UR - millerv@email.chop.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-12542-001
AN - 2009-12542-001
AU - Kumar, Virender
AU - Encinosa, William
T1 - Effects of antidepressant treatment on antiretroviral regimen adherence among depressed HIV-infected patients.
JF - Psychiatric Quarterly
JO - Psychiatric Quarterly
JA - Psychiatr Q
Y1 - 2009/09//
VL - 80
IS - 3
SP - 131
EP - 141
CY - Germany
PB - Springer
SN - 0033-2720
SN - 1573-6709
AD - Encinosa, William, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, US, 27850
N1 - Accession Number: 2009-12542-001. PMID: 19387832 Partial author list: First Author & Affiliation: Kumar, Virender; Westat, Rockville, MD, US. Release Date: 20091102. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; Drug Therapy; HIV; Major Depression; Patients. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Sep, 2009. Publication History: First Posted Date: Apr 22, 2009. Copyright Statement: Springer Science+Business Media, LLC. 2009.
AB - This study examined whether the relationship between HAART medication adherence and antidepressant treatment varied with HAART regimen complexity. The analysis included 1,192 respondents to the HIV Cost and Service Utilization Study (HCSUS) who were taking HAART. Self-reported past-week HAART adherence, antidepressant use, current mental health status, and an aggregate measure of regimen complexity were used in the analysis. Regression models with interactions between antidepressant treatment of mental health problems, poor emotional well-being or depressive symptoms, and medication complexity were estimated to assess differential associations with adherence. Irrespective of antidepressant treatment, poor mental health status was negatively associated with HAART medication adherence. However, only untreated higher depressive symptoms were strongly associated with maladherence to HAART medication (OR = 0.72 at P < 0.05). Medication complexity was strongly associated with maladherence to HAART medication (OR = 0.96 with P < 0.05) in the model including emotional well-being; and weakly associated with maladherence (OR = 0.97 and P < 0.07) in the model including depressive and/or anxiety symptoms. However, as HAART medication complexity increased, adherence was higher among individuals with poorer mental health but using antidepressants compared to those with better mental health (OR = 1.09 with P < 0.05 in the model including emotional well-being; OR = 1.09 and P < 0.05 in the model including depressive and/or anxiety symptoms), and compared to those with poorer mental health but not using antidepressants (OR = 1.09, P = 0.08 in the model including emotional well-being, and OR = 1.12, P < 0.05 in model including depressive and/or anxiety symptoms). In conclusion, while individuals with poorer mental health generally have poor HAART adherence, their adherence improved with the use of antidepressants as the HAART complexity increased. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - antidepressant treatment
KW - antiretroviral regimen adherence
KW - HIV
KW - patients
KW - drug therapy
KW - major depression
KW - 2009
KW - Antidepressant Drugs
KW - Drug Therapy
KW - HIV
KW - Major Depression
KW - Patients
KW - 2009
DO - 10.1007/s11126-009-9100-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-12542-001&site=ehost-live&scope=site
UR - William.Encinosa@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11465-006
AN - 2009-11465-006
AU - Calsyn, Donald A.
AU - Hatch-Maillette, Mary
AU - Tross, Susan
AU - Doyle, Suzanne R.
AU - Crits-Christoph, Paul
AU - Song, Yong S.
AU - Harrer, Judy M.
AU - Lalos, Genise
AU - Berns, Sara B.
T1 - Motivational and skills training HIV/sexually transmitted infection sexual risk reduction groups for men.
JF - Journal of Substance Abuse Treatment
JO - Journal of Substance Abuse Treatment
JA - J Subst Abuse Treat
Y1 - 2009/09//
VL - 37
IS - 2
SP - 138
EP - 150
CY - Netherlands
PB - Elsevier Science
SN - 0740-5472
AD - Calsyn, Donald A., Alcohol and Drug Abuse Institute, 1107 NE 45th St., Ste. 120, Seattle, WA, US, 98105
N1 - Accession Number: 2009-11465-006. PMID: 19150206 Partial author list: First Author & Affiliation: Calsyn, Donald A.; Alcohol and Drug Abuse Institute, University of Washington, Seattle, WA, US. Release Date: 20090914. Correction Date: 20140519. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual Scientific Meeting of the College on Problems of Drug Dependence, Jun, 2007, Quebec City, PQ, Canada. Grant Information: Donovan, Dennis. Conference Note: Presented in part at the aforementioned conference and at the Annual Convention of the American Psychological Association, August 20, 2007, San Francisco, CA, USA; The American Association for the Treatment of Opioid Dependence National Conference, October 23, 2007, San Diego, CA, USA; The Annual Meeting of the American Academy of Addiction Psychiatry, December 1, 2007, San Diego, CA, USA. Major Descriptor: HIV; Motivation Training; Sexually Transmitted Diseases; Skill Learning. Minor Descriptor: Drug Abuse; Human Males; Methadone Maintenance; Outpatients; Sexual Risk Taking; Treatment. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10); Male (30); Outpatient (60). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Risk Behavior Survey; Sex and Drug Abuse Relationship Interview; Sexual Risk Behavior Assessment Schedule; Addiction Severity Index-Lite; Sexual Behavior Interview DOI: 10.1037/t30366-000; Mini Mental State Examination. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Sep, 2009. Publication History: Accepted Date: Nov 24, 2008; Revised Date: Oct 17, 2008; First Submitted Date: Aug 4, 2008. Copyright Statement: All rights reserved. Elsevier Inc. 2009.
AB - The effectiveness of a motivational and skills training HIV/AIDS group intervention designed for men in substance abuse treatment was evaluated. Men in methadone maintenance (n = 288) or outpatient psychosocial treatment (n = 302) completed assessments at baseline, 2 weeks, 3 months, and 6 months post intervention. Participants were randomly assigned to attend either Real Men Are Safe (REMAS; five sessions containing information, motivational exercises, and skills training) or HIV education (HIV-Ed; one session containing HIV prevention information). REMAS participants engaged in significantly fewer unprotected vaginal and anal sexual intercourse occasions (USO) during the 90 days prior to the 3- and 6-month follow-ups than HIV-Ed participants. Completing REMAS resulted in an even stronger effect: Completers reduced their number of USO by 21% from baseline to 6-month follow-up. In contrast, HIV-Ed completers increased the number of USO by 2%. A motivational and skills training HIV prevention intervention designed for men was associated with greater sexual risk reduction over standard HIV-Ed. Substance abuse treatment programs can therefore help reduce sexual risk among their clientele by providing a more intensive intervention than what is traditionally provided. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - motivational & skills training
KW - HIV
KW - sexually transmitted infection
KW - sexual risk reduction
KW - men
KW - substance abuse
KW - methadone maintenance
KW - outpatient psychosocial treatment
KW - 2009
KW - HIV
KW - Motivation Training
KW - Sexually Transmitted Diseases
KW - Skill Learning
KW - Drug Abuse
KW - Human Males
KW - Methadone Maintenance
KW - Outpatients
KW - Sexual Risk Taking
KW - Treatment
KW - 2009
U1 - Sponsor: National Institute on Drug Abuse, Clinical Trials Network, US. Grant: U10 DA13714. Recipients: Donovan, Dennis (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13035. Recipients: Nunes, Edward (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10DA15815. Recipients: Sorensen, James (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13043. Recipients: Woody, George (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13038. Recipients: Carroll, Kathleen (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13711. Recipients: Hubbard, Robert (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13732. Recipients: Somoza, Eugene (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13045. Recipients: Ling, Walter (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA13727. Recipients: Brady, Kathleen (Prin Inv)
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: U10 DA15833. Recipients: Miller, William (Prin Inv)
DO - 10.1016/j.jsat.2008.11.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11465-006&site=ehost-live&scope=site
UR - calsyn@u.washington.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-01862-017
AN - 2010-01862-017
AU - Ishimatsu, Kazuma
AU - Shibata, Nobuyuki
AU - Maeda, Setsuo
T1 - Effects of whole-body vibration on visual information processing.
JF - The Japanese Journal of Psychonomic Science
JO - The Japanese Journal of Psychonomic Science
JA - Jpn J Psychon Sci
Y1 - 2009/09//
VL - 28
IS - 1
SP - 179
EP - 180
CY - Japan
PB - Japanese Psychonomic Society
SN - 0287-7651
SN - 2188-7977
AD - Ishimatsu, Kazuma, Department of Research Planning and Coordinations, National Institute Occupational Safety and Health, 6-21-1 Tama-ku, Kawasaki, Japan, 214-8585
N1 - Accession Number: 2010-01862-017. Partial author list: First Author & Affiliation: Ishimatsu, Kazuma; National Institute of Occupational Safety and Health, Japan. Release Date: 20100913. Correction Date: 20160509. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Vibration; Visual Acuity; Visual Tracking. Minor Descriptor: Color Perception. Classification: Visual Perception (2323). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 2. Issue Publication Date: Sep, 2009. Copyright Statement: All rights reserved. The Japanese Psychonomic Society. 2009.
AB - The present study investigated whether visual information processing deteriorates during exposure to whole-body vibration (WBV). It focused on the frequency effects of the vibration on target color discrimination and target detection performance. Eight participants performed target color discrimination and target detection tasks with, and without, 5 Hz and 16 Hz sinusoidal vertical vibration at a magnitude of 1.0 ms-2 r.m.s.. Their reaction times (RTs) as a function of inter-stimulus intervals (ISls) between a fixation display and a target display were compared for three experimental blocks: baseline without vibration (0 Hz); 5 Hz vibration; and 16 Hz vibration. In the target discrimination tasks the RTs during shorter ISIs in the 5 Hz block were significantly briefer than during the 0 Hz and 16 Hz blocks. For target detection, on the other hand, no significant difference was found between the three experimental blocks. These results suggested that visual information processing (i.e., target color discrimination) could be improved during exposure to 5 Hz sinusoidal vertical WBV. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - whole body vibration
KW - visual information processing
KW - visual target
KW - color discrimination
KW - visual information
KW - 2009
KW - Vibration
KW - Visual Acuity
KW - Visual Tracking
KW - Color Perception
KW - 2009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-01862-017&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-11422-002
AN - 2009-11422-002
AU - McMillen, Curtis J.
AU - Lenze, Shannon L.
AU - Hawley, Kristin M.
AU - Osborne, Victoria A.
T1 - Revisiting practice-based research networks as a platform for mental health services research.
JF - Administration and Policy in Mental Health and Mental Health Services Research
JO - Administration and Policy in Mental Health and Mental Health Services Research
Y1 - 2009/09//
VL - 36
IS - 5
SP - 308
EP - 321
CY - Germany
PB - Springer
SN - 0894-587X
SN - 1573-3289
AD - McMillen, Curtis J., George Warren Brown School of Social Work, Washington University in St. Louis, St. Louis, MO, US
N1 - Accession Number: 2009-11422-002. Other Journal Title: Administration and Policy in Mental Health; Administration in Mental Health. Partial author list: First Author & Affiliation: McMillen, Curtis J.; Center for Mental Health Services Research, Washington University in St. Louis, St. Louis, MO, US. Release Date: 20090907. Correction Date: 20100920. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Clinicians; Evidence Based Practice; Mental Health Services; Research and Development; Health Care Policy. Minor Descriptor: Behavior; Intervention. Classification: Health & Mental Health Services (3370). Population: Human (10). Supplemental Data: Other Internet. References Available: Y. Page Count: 14. Issue Publication Date: Sep, 2009. Publication History: Accepted Date: Apr 14, 2009; First Submitted Date: Feb 5, 2009. Copyright Statement: Springer Science+Business Media, LLC. 2009.
AB - Practice-based research networks (PBRNs)—collaborations of practice settings that work together to generate research knowledge—are underused in mental health services research. This article proposes an agenda for mental health services research that uses a variety of PBRN structures and that focuses on what really happens in practice, the effectiveness of practice innovations in real world care, the challenges of implementing evidence supported interventions, modification of clinician behavior, and assessment of the effect of mental health policy changes on practice. The challenges of conducting research within PBRNs are substantial, including difficulties in maintaining positive member relations, securing ongoing funding, sustaining productivity, overcoming IRB entanglements and achieving both scientific excellence in recruitment and measurement validity and utility for practitioner members. However, the awareness of these challenges allows researchers and practitioners to build networks that creatively overcome them and that infuse mental health services research with heavy doses of the realities of everyday clinical practice. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - practice based research networks
KW - mental health services research
KW - interventions
KW - clinician behavior
KW - mental health policy
KW - 2009
KW - Clinicians
KW - Evidence Based Practice
KW - Mental Health Services
KW - Research and Development
KW - Health Care Policy
KW - Behavior
KW - Intervention
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: P30MH068579. Recipients: No recipient indicated
DO - 10.1007/s10488-009-0222-2
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-11422-002&site=ehost-live&scope=site
UR - cmcmille@wustl.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-14397-008
AN - 2009-14397-008
AU - Lapinski, Maria Knight
AU - Randall, Liisa M.
AU - Peterson, Mark
AU - Peterson, Amy
AU - Klein, Katherine A.
T1 - Prevention options for positives: The effects of a health communication intervention for men who have sex with men living with HIV/AIDS.
JF - Health Communication
JO - Health Communication
JA - Health Commun
Y1 - 2009/09//
VL - 24
IS - 6
SP - 562
EP - 571
CY - United Kingdom
PB - Taylor & Francis
SN - 1041-0236
SN - 1532-7027
AD - Lapinski, Maria Knight, Department of Communication, Michigan State University, East Lansing, MI, US, 48824
N1 - Accession Number: 2009-14397-008. PMID: 19735033 Partial author list: First Author & Affiliation: Lapinski, Maria Knight; Department of Communication, Michigan State University, East Lansing, MI, US. Other Publishers: Lawrence Erlbaum. Release Date: 20100201. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: AIDS Prevention; Health Education; Health Promotion; HIV; Intervention. Minor Descriptor: Group Counseling; Individual Psychotherapy; Male Homosexuality. Classification: Promotion & Maintenance of Health & Wellness (3365). Population: Human (10); Male (30). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Sep, 2009. Copyright Statement: Taylor & Francis Group, LLC
AB - This article reports the results of a small-scale quasi-experiment that tested the efficacy of the Prevention Options for Positives intervention. The experiment tested for the outcomes of group sessions combined with individual-level counseling (ILC) versus ILC-only for men who have sex with men who are HIV positive. Both arms of the intervention were based on behavior change theory and dealt specifically with communication outcomes. The results indicate that the group- and individual-level interventions combined have a greater impact on risk communication behaviors with main partners than did the ILC-only sessions. group-session/ ILC participants were more likely to decide not to have sex if they were drunk or high, and more likely to tell their partner and ask their partner about HIV status than were participants in the ILC groups. Knowledge about HIV was relatively high, and there was little change across groups. The Prevention Options for Positives intervention influenced the relative importance of various referent groups, but normative beliefs were not affected. The implications of these findings for communication practice and research with HIV-positive men who have sex with men are addressed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - AIDS prevention
KW - health communication intervention
KW - HIV
KW - same sex intercourse
KW - individual level counseling
KW - gays
KW - 2009
KW - AIDS Prevention
KW - Health Education
KW - Health Promotion
KW - HIV
KW - Intervention
KW - Group Counseling
KW - Individual Psychotherapy
KW - Male Homosexuality
KW - 2009
DO - 10.1080/10410230903104947
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-14397-008&site=ehost-live&scope=site
UR - lapinsk3@msu.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-03219-010
AN - 2011-03219-010
AU - Buunk-Werkhoven, Yvonne A. B.
AU - Dijkstra, Arie
AU - van der Wal, Henk
AU - Basic, Nina
AU - Loomans, Steven A.
AU - van der Schans, Cees P.
AU - van der Meer, Rob
T1 - Promoting oral hygiene behavior in recruits in the Dutch army.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2009/09//
VL - 174
IS - 9
SP - 971
EP - 976
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Buunk-Werkhoven, Yvonne A. B., Research Group in Health Care and Nursing, Hanze University Applied Sciences, roningen Eyssoniusplein 18, Postbus 3109, 9701 DC, Groningen, Netherlands
N1 - Accession Number: 2011-03219-010. PMID: 19780374 Partial author list: First Author & Affiliation: Buunk-Werkhoven, Yvonne A. B.; Research Group in Health Care and Nursing, Hanze University Applied Sciences, Groningen, Netherlands. Release Date: 20110704. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Annual 2008 AMSUS International Delegates Poster Session, Nov, 2008, San Antonio, TX, US. Conference Note: The previous poster presented as “Promoting Oral Health Self-Care in Recruits in the Dutch Army” at the aforementioned conference. Major Descriptor: Army Personnel; Health Behavior; Health Promotion; Hygiene; Oral Health. Classification: Promotion & Maintenance of Health & Wellness (3365); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340). Tests & Measures: Index for Oral Hygiene Behavior. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Sep, 2009. Copyright Statement: Association of Military Surgeons of U.S. 2009.
AB - Objectives: To make practical recommendations for improving oral hygiene behavior (OHB) potential predictors based on the Theory of Planned Behavior (TPB) were assessed. Measurements of oral health knowledge (OHK) and the expected social effect for having healthy teeth were included. Methods: 216 recruits in the Dutch Army ground forces completed a questionnaire about oral hygiene behavior, attitudes, social norms, perceived behavioral control (PBC), intention to perform optimal OHB, OHK, and expected social outcomes. Results: The multivariate regression analysis revealed that attitude and PBC explained 37.2% of the variance in intention to perform optimal oral hygiene behavior, which is a substantial proportion. Furthermore, actual oral hygiene behavior was only predicted by attitude, explaining 7.1% of the variance. Conclusion: The present findings suggest that recruits’ oral hygiene behavior may be improved by promoting a more positive attitude and especially by enhancing perceived behavior control. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - health promotion
KW - oral hygiene behavior
KW - Dutch army
KW - 2009
KW - Army Personnel
KW - Health Behavior
KW - Health Promotion
KW - Hygiene
KW - Oral Health
KW - 2009
DO - 10.7205/MILMED-D-05-0408
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-03219-010&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17783-009
AN - 2009-17783-009
AU - Hsiao, Hongwei
AU - Friess, Martin
AU - Bradtmiller, Bruce
AU - Rohlf, F. James
T1 - Development of sizing structure for fall arrest harness.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2009/09//
VL - 52
IS - 9
SP - 1128
EP - 1143
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Hsiao, Hongwei
N1 - Accession Number: 2009-17783-009. PMID: 19606363 Partial author list: First Author & Affiliation: Hsiao, Hongwei; Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, US. Release Date: 20091019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Accident Prevention; Body Size; Falls; Human Factors Engineering. Classification: Human Factors Engineering (4010). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 16. Issue Publication Date: Sep, 2009. Copyright Statement: Taylor & Francis. 2009.
AB - Updated harness designs are needed to accommodate diverse populations in the current workforce. This paper determined an improved fall-arrest harness sizing scheme and strap-length configurations for harness design. A 3-D elliptic Fourier analysis (EFA) procedure with 123 coefficients was developed to quantify torso-shape effect on harness fit, based on 3-D data of 108 women and 108 men. The EFA coefficients were then applied to 600 representative body scans from a national database of 2382 participants to establish an improved sizing system. Study outcomes suggested a more upward back D-ring location for women than current unisex designs to accommodate female torso form and mitigate their fit problem. Results also suggested an improved system of three sizes for women and three sizes for men. New harness sizing charts for women and men were proposed accordingly. Using the most current 3-D whole-body digital scanning technology, this study assembled data from a US workforce to establish an improved fall-arrest harness sizing system and strap configurations for men and women. The information is useful for new generation harness designs to reduce the risk of worker injury. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - harness designs
KW - fall-arrest harness sizing scheme
KW - strap-length configurations
KW - torso-shape
KW - 2009
KW - Accident Prevention
KW - Body Size
KW - Falls
KW - Human Factors Engineering
KW - 2009
DO - 10.1080/00140130902919105
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17783-009&site=ehost-live&scope=site
UR - hxh4@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18465-014
AN - 2009-18465-014
AU - Mark, Tami L.
AU - Levit, Katharine R.
AU - Buck, Jeffrey A.
T1 - Psychotropic drug prescriptions by medical specialty.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/09//
VL - 60
IS - 9
SP - 1167
EP - 1167
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Mark, Tami L., Thomson Reuters, 4301 Connecticut Ave., N.W., Suite 330, Washington, DC, US, 20008
N1 - Accession Number: 2009-18465-014. PMID: 19723729 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Mark, Tami L.; Thomson Reuters, Washington, DC, US. Release Date: 20100809. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Antidepressant Drugs; General Practitioners; Physicians; Prescribing (Drugs); Prescription Drugs. Classification: Professional Personnel Attitudes & Characteristics (3430). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 1. Issue Publication Date: Sep, 2009.
AB - The important role of general practitioners in prescribing antidepressant medications and treating depression has been documented. However, the extent to which general practitioners are prescribing other types of psychotropic medications has received less emphasis. This study used data from August 2006 to July 2007 from the National Prescription Audit (NPA) Plus database of IMS to examine this question. IMS collects transaction information each month from approximately 36,000 retail pharmacies, representing about 70% of all retail pharmacies, which when weighted represent all prescriptions filled in retail outlets in the United States. In 2004–2005, about two-thirds of primary care physicians reported that they were unable to obtain outpatient mental health services for patients. Given the large role of primary care providers in psychotropic drug prescribing, additional efforts may be needed to enhance the quality of psychiatric treatment in general practice settings across a range of psychiatric conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - psychotropic drug prescriptions
KW - medical specialties
KW - general practitioners
KW - antidepressant medications
KW - physicians
KW - 2009
KW - Antidepressant Drugs
KW - General Practitioners
KW - Physicians
KW - Prescribing (Drugs)
KW - Prescription Drugs
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Recipients: No recipient indicated
DO - 10.1176/appi.ps.60.9.1167
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18465-014&site=ehost-live&scope=site
UR - tami.mark@thomsonreuters.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17783-014
AN - 2009-17783-014
AU - Lowe, Brian D.
AU - Krieg, Edward F.
T1 - Relationships between observational estimates and physical measurements of upper limb activity: Corrigendum.
JF - Ergonomics
JO - Ergonomics
JA - Ergonomics
Y1 - 2009/09//
VL - 52
IS - 9
SP - 1183
EP - 1183
CY - United Kingdom
PB - Taylor & Francis
SN - 0014-0139
SN - 1366-5847
AD - Lowe, Brian D., National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, US, 45226
N1 - Accession Number: 2009-17783-014. Partial author list: First Author & Affiliation: Lowe, Brian D.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20091019. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Erratum/Correction. Language: English. Major Descriptor: Human Factors Engineering; Limbic System; Motor Processes. Classification: Motor Processes (2330); Engineering & Environmental Psychology (4000). Population: Human (10). Page Count: 1. Issue Publication Date: Sep, 2009. Copyright Statement: Taylor & Francis. 2009.
AB - Reports an error in 'Relationships between observational estimates and physical measurements of upper limb activity' by Brian D. Lowe and Edward F. Krieg (Ergonomics, 2009[May], Vol 52[5], 569-583). This paper (Ergonomics 52 (5), pp. 569–583) contains an error in the interpretation of the Hand Activity Level (HAL) rating in relation to the measured hand force duty cycle. (The following abstract of the original article appeared in record [rid]2009-08388-005[/rid].) This study examined the internal validity of observational-based ergonomic job analysis methods for assessing upper limb force exertion and repetitive motion. Six manual tasks were performed by multiple ‘workers’ while direct measurements were made to quantify force exertion and kinematics of the upper limb. Observational-based analyses of force and upper limb motion/repetition were conducted by 29 professional ergonomists. These analysts overestimated the magnitude of individual force exertions—temporal aspects of force exertion (duty cycle) were estimated more accurately. Estimates of the relative severity of repetitive motions among the jobs were accurate. Absolute counts of repetitive motions were less accurate. Modest correlations (r² = 0.28 to r² = 0.50) were observed between ratings of hand activity level and measured joint velocities. Ergonomic job analyses relying on systematic observation should be applied and interpreted with consideration given to the capabilities and limitations of analysts in estimating the physical risk factors. These findings are relevant to a better understanding of the internal validity of ergonomic job analysis methods based on systematic observation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - upper limb activity
KW - ergonomics
KW - motor processes
KW - 2009
KW - Human Factors Engineering
KW - Limbic System
KW - Motor Processes
KW - 2009
DO - 10.1080/00140130903148761
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17783-014&site=ehost-live&scope=site
UR - blowe@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Finkelstein, Eric A.
AU - Trogdon, Justin G.
AU - Cohen, Joel W.
AU - Dietz, William
T1 - Annual Medical Spending Attributable To Obesity: Payer- And Service-Specific Estimates.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/09/02/Sep2009 Supplement
VL - 28
M3 - Article
SP - w822
EP - w831
SN - 02782715
AB - In 1998 the medical costs of obesity were estimated to be as high as $78.5 billion, with roughly half financed by Medicare and Medicaid. This analysis presents updated estimates of the costs of obesity for the United States across payers (Medicare, Medicaid, and private insurers), in separate categories for inpatient, non-inpatient, and prescription drug spending. We found that the increased prevalence of obesity is responsible for almost $40 billion of increased medical spending through 2006, including $7 billion in Medicare prescription drug costs. We estimate that the medical costs of obesity could have risen to $147 billion per year by 2008. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
N1 - Accession Number: 59906770; Finkelstein, Eric A. 1; Email Address: finkelse@rti.org Trogdon, Justin G. 1 Cohen, Joel W. 2 Dietz, William 3; Affiliation: 1: Director, Public Health Economics Program, RTI International, Research Triangle Park, North Carolina 2: Director, Division of Social and Economic Research, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland 3: Director, Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: Sep2009 Supplement, Vol. 28, pw822; Number of Pages: 10p; Document Type: Article
L3 - 10.1377/hlthaff.28.5.w822
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=59906770&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fayer, Ronald
AU - Orlandi, Palmer
AU - Perdue, Michael L.
T1 - Virulence factor activity relationships for hepatitis E and Cryptosporidium.
JO - Journal of Water & Health
JF - Journal of Water & Health
Y1 - 2009/09/02/Sep2009 Supplement 1
VL - 7
M3 - Article
SP - S55
EP - S63
SN - 14778920
AB - The hepatitis E virus and Cryptosporidium are waterborne pathogens, each consisting of distinct taxa, genotypes and isolates that infect humans, nonhuman animal species or both. Some are associated with disease, others are not. Factors contributing to disease are extremely complicated, possibly involving differences in one or more traits associated with an organism's taxon, genotype or isolate and its infectious dose, and age or condition, as well as the host's physiology and immune status. Potential virulence factors have not yet been identified for HEV. Putative virulence factors for Cryptosporidium might be found in recently recognized genes involved in processes such as excystation, adherence to host cells, invasion, intracellular maintenance and host cell destruction. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Water & Health is the property of IWA Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cryptosporidium
KW - Waterborne infection
KW - Pathogenic microorganisms
KW - Hepatitis E
KW - Animal species
KW - Excystment (Dormancy)
KW - cryptosporidiosis
KW - epidemiology
KW - hepatitis
KW - molecular
KW - proteins
KW - taxonomy
N1 - Accession Number: 44231900; Fayer, Ronald 1; Email Address: ronald.fayer@ars.usda.gov; Orlandi, Palmer 2; Perdue, Michael L. 3; Affiliations: 1: United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville MD 20705, USA; 2: Division of Field Science, ORA, Food and Drug Administration, Rockville, MD 20857, USA; 3: Division of Influenza and Emerging Diseases, Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Sciences, Washington, DC 20201, USA; Issue Info: Sep2009 Supplement 1, Vol. 7, pS55; Thesaurus Term: Cryptosporidium; Thesaurus Term: Waterborne infection; Thesaurus Term: Pathogenic microorganisms; Subject Term: Hepatitis E; Subject Term: Animal species; Subject Term: Excystment (Dormancy); Author-Supplied Keyword: cryptosporidiosis; Author-Supplied Keyword: epidemiology; Author-Supplied Keyword: hepatitis; Author-Supplied Keyword: molecular; Author-Supplied Keyword: proteins; Author-Supplied Keyword: taxonomy; Number of Pages: 9p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.2166/wh.2009.044
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44231900&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - NEWS
AU - Unger, Ellis F.
T1 - Weighing Benefits and Risks — The FDA's Review of Prasugrel.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/09/03/
VL - 361
IS - 10
M3 - Editorial
SP - 942
EP - 945
SN - 00284793
AB - The author discusses the benefits and risks of using prasugrel, which was approved by the U.S. Food and Drug Administration (FDA) for reducing thrombotic cardiovascular events in patients suffering from myocardial infarction or unstable angina. He says that prasugrel reduced end-point events, however, it was associated with an increased risk of bleeding of about 30 percent. He adds that the FDA made sure that the label of prasugrel clearly shows the balance between risk and efficacy. He also discusses how bleeding became a serious concern with prasugrel.
KW - CORONARY heart disease -- Treatment
KW - HEMORRHAGE
KW - HEART diseases
KW - RISK factors
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 44035376; Unger, Ellis F. 1; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 9/3/2009, Vol. 361 Issue 10, p942; Subject Term: CORONARY heart disease -- Treatment; Subject Term: HEMORRHAGE; Subject Term: HEART diseases; Subject Term: RISK factors; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 4p; Document Type: Editorial; Full Text Word Count: 1507
L3 - 10.1056/NEJMp0907122
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44035376&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105423057
T1 - Weighing benefits and risks--the FDA's review of prasugrel.
AU - Unger EF
Y1 - 2009/09/03/
N1 - Accession Number: 105423057. Language: English. Entry Date: 20090925. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Angina, Unstable -- Drug Therapy
KW - Angioplasty, Transluminal, Percutaneous Coronary
KW - Coronary Thrombosis -- Prevention and Control
KW - Hemorrhage -- Chemically Induced
KW - Heterocyclic Compounds -- Therapeutic Use
KW - Myocardial Infarction -- Drug Therapy
KW - Platelet Aggregation Inhibitors -- Therapeutic Use
KW - Sulfur Compounds -- Therapeutic Use
KW - Aspirin -- Therapeutic Use
KW - Cardiovascular Diseases -- Epidemiology
KW - Cardiovascular Diseases -- Mortality
KW - Causal Attribution
KW - Clinical Trials
KW - Combined Modality Therapy
KW - Drug Administration Schedule
KW - Drug Therapy, Combination
KW - Heterocyclic Compounds -- Adverse Effects
KW - Neoplasms -- Epidemiology
KW - Platelet Aggregation Inhibitors -- Adverse Effects
KW - Sulfur Compounds -- Adverse Effects
KW - United States Food and Drug Administration
KW - United States
SP - 942
EP - 945
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 361
IS - 10
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
U2 - PMID: 19726770.
DO - 10.1056/NEJMp0907122
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105423057&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gratz, Samuel R.
AU - Zeller, Matthias
AU - Mincey, Daryl W.
AU - Flurer, Cheryl L.
T1 - Structural characterization of sulfoaildenafil, an analog of sildenafil
JO - Journal of Pharmaceutical & Biomedical Analysis
JF - Journal of Pharmaceutical & Biomedical Analysis
Y1 - 2009/09/08/
VL - 50
IS - 2
M3 - Article
SP - 228
EP - 231
SN - 07317085
AB - Abstract: Phosphodiesterase type 5 (PDE-5) inhibitors represent a class of drugs used primarily in the treatment of erectile dysfunction. Currently, three PDE-5 inhibitors have been approved by the U.S. Food and Drug Administration (FDA) for use in the United States: sildenafil citrate, tadalafil, and vardenafil hydrochloride trihydrate. A bulk material, labeled as an ingredient for a dietary supplement, was analyzed for the presence of PDE-5 inhibitors. The compound that was detected displayed structural similarities to sildenafil, and was characterized further using LC–MS n , FTICRMS, X-ray crystallography and NMR. The compound was given the name sulfoaildenafil. When compared to sildenafil, sulfoaildenafil contains a sulfur atom substitution for the oxygen atom in the pyrazolopyrimidine portion of the molecule, and a 3,5-dimethyl substitution on the piperazine ring, rather than the 4-methyl moiety. The X-ray crystallographic data indicate that the material in this sample is comprised of two polymorphs, which may affect the chemical and/or biological properties of any product formulated with this compound. [Copyright &y& Elsevier]
AB - Copyright of Journal of Pharmaceutical & Biomedical Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILDENAFIL
KW - DRUGS -- Derivatives
KW - PHOSPHODIESTERASES
KW - ENZYME inhibitors
KW - NUCLEAR magnetic resonance
KW - STRUCTURAL analysis (Science)
KW - X-ray crystallography
KW - LIQUID chromatography
KW - MASS spectrometry
KW - NUCLEAR magnetic resonance spectroscopy
KW - Accurate mass
KW - Dietary supplement
KW - Liquid chromatography–mass spectrometry (LC–MS)
KW - Nuclear magnetic resonance (NMR)
KW - PDE-5 inhibitors
KW - Sulfoaildenafil
N1 - Accession Number: 41241787; Gratz, Samuel R. 1 Zeller, Matthias 2 Mincey, Daryl W. 2 Flurer, Cheryl L. 1; Email Address: cheryl.flurer@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA 2: Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH 44555, USA; Source Info: Sep2009, Vol. 50 Issue 2, p228; Subject Term: SILDENAFIL; Subject Term: DRUGS -- Derivatives; Subject Term: PHOSPHODIESTERASES; Subject Term: ENZYME inhibitors; Subject Term: NUCLEAR magnetic resonance; Subject Term: STRUCTURAL analysis (Science); Subject Term: X-ray crystallography; Subject Term: LIQUID chromatography; Subject Term: MASS spectrometry; Subject Term: NUCLEAR magnetic resonance spectroscopy; Author-Supplied Keyword: Accurate mass; Author-Supplied Keyword: Dietary supplement; Author-Supplied Keyword: Liquid chromatography–mass spectrometry (LC–MS); Author-Supplied Keyword: Nuclear magnetic resonance (NMR); Author-Supplied Keyword: PDE-5 inhibitors; Author-Supplied Keyword: Sulfoaildenafil; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.jpba.2009.04.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=41241787&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jana Semberova
AU - Silvia H. De Paoli Lacerda
AU - Olga Simakova
AU - Karel Holada
AU - Monique P. Gelderman
AU - Jan Simak
T1 - Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca2+Influx Sensitive to Calcium Entry Inhibitors.
JO - Nano Letters
JF - Nano Letters
Y1 - 2009/09/09/
VL - 9
IS - 9
M3 - Article
SP - 3312
EP - 3317
SN - 15306984
AB - To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca2+influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nano Letters is the property of American Chemical Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARBON nanotubes
KW - BLOOD platelets
KW - CALCIUM antagonists
KW - CALCIUM channels
KW - BIOCHEMICAL markers
KW - EXTRACELLULAR fluid
KW - BIOLOGICAL transport
N1 - Accession Number: 44778741; Jana Semberova 1 Silvia H. De Paoli Lacerda 1 Olga Simakova 1 Karel Holada 1 Monique P. Gelderman 1 Jan Simak 1; Affiliation: 1: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852-1448, Institute for the Care of Mother and Child, Prague, Czech Republic, First Medical School, Charles University, Prague, Czech Republic, and NIH Clinical Center, Bethesda, Maryland 20892; Source Info: Sep2009, Vol. 9 Issue 9, p3312; Subject Term: CARBON nanotubes; Subject Term: BLOOD platelets; Subject Term: CALCIUM antagonists; Subject Term: CALCIUM channels; Subject Term: BIOCHEMICAL markers; Subject Term: EXTRACELLULAR fluid; Subject Term: BIOLOGICAL transport; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Harel, Liraz
AU - Costa, Barbara
AU - Tcherpakov, Marianna
AU - Zapatka, Marc
AU - Oberthuer, Andre
AU - Hansford, Loen M.
AU - Vojvodic, Milijana
AU - Levy, Zehava
AU - Chen, Zhe-Yu
AU - Lee, Francis S.
AU - Avigad, Smadar
AU - Yaniv, Isaac
AU - Shi, Leming
AU - Eils, Roland
AU - Fischer, Matthias
AU - Brors, Benedikt
AU - Kaplan, David R.
AU - Fainzilber, Mike
T1 - CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase
JO - Neuron
JF - Neuron
Y1 - 2009/09/10/
VL - 63
IS - 5
M3 - Article
SP - 585
EP - 591
SN - 08966273
AB - Summary: The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism. Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the juxtamembrane region of TrkA via its phosphotyrosine binding (PTB) domain and mediates TrkA-induced death in diverse cell types. Both the PTB and Karet domains of CCM2 are required for TrkA-dependent cell death, such that the PTB domain determines the specificity of the interaction, and the Karet domain links to death pathways. Downregulation of CCM2 in medulloblastoma or neuroblastoma cells attenuates TrkA-dependent death. Combined high expression levels of CCM2 and TrkA are correlated with long-term survival in a large cohort of human neuroblastoma patients. Thus, CCM2 is a key mediator of TrkA-dependent cell death in pediatric neuroblastic tumors. [Copyright &y& Elsevier]
AB - Copyright of Neuron is the property of Cell Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN-tyrosine kinase
KW - CELL receptors
KW - CELL death
KW - CELLULAR signal transduction
KW - CELL differentiation
KW - TUMORS in children
KW - NERVE Growth Factor
KW - CELLBIO
KW - MOLNEURO
KW - SIGNALING
N1 - Accession Number: 44176960; Harel, Liraz 1 Costa, Barbara 1 Tcherpakov, Marianna 1 Zapatka, Marc 2 Oberthuer, Andre 3 Hansford, Loen M. 4 Vojvodic, Milijana 4 Levy, Zehava 1 Chen, Zhe-Yu 5 Lee, Francis S. 6 Avigad, Smadar 7 Yaniv, Isaac 7 Shi, Leming 8 Eils, Roland 2,9 Fischer, Matthias 3 Brors, Benedikt 2 Kaplan, David R. 4 Fainzilber, Mike 1; Email Address: mike.fainzilber@weizmann.ac.il; Affiliation: 1: Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel 2: German Cancer Research Center, Department Theoretical Bioinformatics B080, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany 3: Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Children's Hospital, Kerpener Strasse 62, 50924 Cologne, Germany 4: Cell Biology Program, Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada 5: Department of Neurobiology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China 6: Departments of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA 7: Pediatric Oncology, Felsenstein Medical Research Center, Schneider Children's Medical Center of Israel, Petah-Tikva 49202, Israel 8: National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA 9: Theoretical Bioinformatics, Department Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, 69120 Heidelberg, Germany; Source Info: Sep2009, Vol. 63 Issue 5, p585; Subject Term: PROTEIN-tyrosine kinase; Subject Term: CELL receptors; Subject Term: CELL death; Subject Term: CELLULAR signal transduction; Subject Term: CELL differentiation; Subject Term: TUMORS in children; Subject Term: NERVE Growth Factor; Author-Supplied Keyword: CELLBIO; Author-Supplied Keyword: MOLNEURO; Author-Supplied Keyword: SIGNALING; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.neuron.2009.08.020
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dong, Ren G.
AU - Welcome, Daniel E.
AU - McDowell, Thomas W.
AU - Wu, John Z.
T1 - Methods for deriving a representative biodynamic response of the hand–arm system to vibration
JO - Journal of Sound & Vibration
JF - Journal of Sound & Vibration
Y1 - 2009/09/11/
VL - 325
IS - 4/5
M3 - Article
SP - 1047
EP - 1061
SN - 0022460X
AB - Abstract: Vibration-induced biodynamic responses (BR) of the human hand–arm system measured with subjects participating in an experiment are usually arithmetically averaged and used to represent their mean response. The mean BR data reported from different studies are further arithmetically averaged to form the reference mean response for standardization and other applications. The objectives of this study are to clarify whether such a response-based averaging process could significantly misrepresent the characteristics of the original responses, and to identify an appropriate derivation method. The arithmetically averaged response was directly compared with the response derived from a property-based method proposed in this study. Two sets of reported mechanical impedance data measured at the fingers and the palms of the hands were used to derive the models required for the comparison. This study found that the response-based arithmetic averaging could generate some systematic errors. The range of the subjects’ natural frequencies in each resonance mode, the mode damping ratio, and the number of subjects participating in the experiment are among the major factors influencing the level of the errors. An effective and practical approach for reducing the potential for error is to increase the number of subjects in the BR measurement. On the other hand, the property-based derivation method can be generally used to obtain the representative response, but it is less efficient than the response-based derivation method. [Copyright &y& Elsevier]
AB - Copyright of Journal of Sound & Vibration is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOMECHANICS
KW - ARM
KW - VIBRATION (Mechanics)
KW - FREQUENCY response (Dynamics)
KW - DAMPING (Mechanics)
KW - MECHANICAL impedance
KW - ARITHMETIC
KW - BIOLOGICAL models
N1 - Accession Number: 43159214; Dong, Ren G.; Email Address: rkd6@cdc.gov Welcome, Daniel E. 1 McDowell, Thomas W. 1 Wu, John Z. 1; Affiliation: 1: National Institute for Occupational Safety and Health, Engineering & Control Technology Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Sep2009, Vol. 325 Issue 4/5, p1047; Subject Term: BIOMECHANICS; Subject Term: ARM; Subject Term: VIBRATION (Mechanics); Subject Term: FREQUENCY response (Dynamics); Subject Term: DAMPING (Mechanics); Subject Term: MECHANICAL impedance; Subject Term: ARITHMETIC; Subject Term: BIOLOGICAL models; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.jsv.2009.04.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105324415
T1 - Screening for illicit drug use.
AU - Lin KW
AU - Finnell VW
Y1 - 2009/09/15/
N1 - Accession Number: 105324415. Language: English. Entry Date: 20091113. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Prenatal Care -- Standards
KW - Substance Abuse Detection -- Methods
KW - Substance Use Disorders -- Diagnosis
KW - Adolescence
KW - Female
KW - Practice Guidelines
KW - Pregnancy
KW - Substance Abuse Detection -- Standards
SP - 629
EP - 629
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 80
IS - 6
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 19817329.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fricke, W. Florian
AU - McDermott, Patrick F.
AU - Mammel, Mark K.
AU - Shaohua Zhao
AU - Johnson, Timothy J.
AU - Rasko, David A.
AU - Fedorka-Cray, Paula J.
AU - Pedroso, Adriana
AU - Whichard, Jean M.
AU - LeClerc, J. Eugene
AU - White, David G.
AU - Cebula, Thomas A.
AU - Ravel, Jacques
T1 - Antimicrobial Resistance-Conferring Plasmids with Similarity to Virulence Plasmids from Avian Pathogenic Escherichia coli Strains in Salmonella enterica Serovar Kentucky Isolates from Poultry.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/09/15/
VL - 75
IS - 18
M3 - Article
SP - 5963
EP - 5971
SN - 00992240
AB - Salmonella enterica, a leading cause of food-borne gastroenteritis worldwide, may be found in any raw food of animal, vegetable, or fruit origin. Salmonella serovars differ in distribution, virulence, and host specificity. Salmonella enterica serovar Kentucky, though often found in the food supply, is less commonly isolated from ill humans. The multidrug-resistant isolate S. Kentucky CVM29188, isolated from a chicken breast sample in 2003, contains three plasmids (146,811 bp, 101,461 bp, and 46,121 bp), two of which carry resistance determinants (pCVM29188_146 [strAB and tetRA] and pCVM29188_101 [blaCMY-2 and sugE]). Both resistance plasmids were transferable by conjugation, alone or in combination, to S. Kentucky, Salmonella enterica serovar Newport, and Escherichia coli recipients. pCVM29188_146 shares a highly conserved plasmid backbone of 106 kb (>90% nucleotide identity) with two virulence plasmids from avian pathogenic Escherichia coli strains (pAPEC-O1-ColBM and pAPEC-O2-ColV). Shared avian pathogenic E. coli (APEC) virulence factors include iutA iucABCD, sitABCD, etsABC, iss, and iroBCDEN. PCR analyses of recent (1997 to 2005) S. Kentucky isolates from food animal, retail meat, and human sources revealed that 172 (60%) contained similar APEC-like plasmid backbones. Notably, though rare in human- and cattle-derived isolates, this plasmid backbone was found at a high frequency (50 to 100%) among S. Kentucky isolates from chickens within the same time span. Ninety-four percent of the APEC-positive isolates showed resistance to tetracycline and streptomycin. Together, our findings of a resistance-conferring APEC virulence plasmid in a poultry-derived S. Kentucky isolate and of similar resistance/virulence plasmids in most recent S. Kentucky isolates from chickens and, to lesser degree, from humans and cattle highlight the need for additional research in order to examine the prevalence and spread of combined virulence and resistance plasmids in bacteria in agricultural, environmental, and clinical settings. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SALMONELLA diseases
KW - PATHOGENIC microorganisms
KW - ENTEROBACTERIACEAE
KW - FOODBORNE diseases
KW - VIRULENCE (Microbiology)
KW - MICROBIAL invasiveness
KW - PLASMIDS
KW - ESCHERICHIA coli
KW - KENTUCKY
N1 - Accession Number: 44770396; Fricke, W. Florian 1 McDermott, Patrick F. 2 Mammel, Mark K. 3 Shaohua Zhao 2 Johnson, Timothy J. 4 Rasko, David A. 1 Fedorka-Cray, Paula J. 5 Pedroso, Adriana 6 Whichard, Jean M. 7 LeClerc, J. Eugene 3 White, David G. 2 Cebula, Thomas A. 8 Ravel, Jacques 1; Email Address: jravel@som.umaryland.edu; Affiliation: 1: Institute for Genome Sciences (IGS), University of Maryland School of Medicine, Baltimore, Maryland 21201 2: Center for Veterinary Medicine, Food and Drug Administration (CVM-FDA), Laurel, Maryland 20708 3: Center for Food Safety and Applied Nutrition, Food and Drug Administration (CFSAN-FDA), Laurel, Maryland 20708 4: University of Minnesota, St. Paul, Minnesota 55108 5: USDA-ARS Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Athens, Georgia 30605 6: Department of Population Health, University of Georgia, Athens, Georgia 30223 7: Division of Foodborne, Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333 8: Johns Hopkins University, Baltimore, Maryland 21218; Source Info: Sep2009, Vol. 75 Issue 18, p5963; Subject Term: SALMONELLA diseases; Subject Term: PATHOGENIC microorganisms; Subject Term: ENTEROBACTERIACEAE; Subject Term: FOODBORNE diseases; Subject Term: VIRULENCE (Microbiology); Subject Term: MICROBIAL invasiveness; Subject Term: PLASMIDS; Subject Term: ESCHERICHIA coli; Subject Term: KENTUCKY; Number of Pages: 9p; Illustrations: 3 Graphs; Document Type: Article
L3 - 10.1128/AEM.00786-09
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kwon, Deborah
AU - Mucci, Diane
AU - Langlais, Kristofor K.
AU - Americo, Jeffrey L.
AU - DeVido, Sarah K.
AU - Yuzhong Cheng
AU - Kassis, Judith A.
T1 - Enhancer-promoter communication at the Drosophila engrailed locus.
JO - Development (09501991)
JF - Development (09501991)
Y1 - 2009/09/15/
VL - 136
IS - 18
M3 - Article
SP - 4
EP - 4
SN - 09501991
AB - Enhancers are often located many tens of kilobases away from the promoter they regulate, sometimes residing closer to the promoter of a neighboring gene. How do they know which gene to activate? We have used homing P[en] constructs to study the enhancer-promoter communication at the engrailed locus. Here we show that engrailed enhancers can act over large distances, even skipping over other transcription units, choosing the engrailed promoter over those of neighboring genes. This specificity is achieved in at least three ways. First, early acting engrailed stripe enhancers exhibit promoter specificity. Second, a proximal promoter-tethering element is required for the action of the imaginal disc enhancer(s). Our data suggest that there are two partially redundant promoter-tethering elements. Third, the long-distance action of engrailed enhancers requires a combination of the engrailed promoter and sequences within or closely linked to the promoter proximal Polycomb-group response elements. These data show that multiple mechanisms ensure proper enhancer-promoter communication at the Drosophila engrailed locus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Development (09501991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DROSOPHILA
KW - LOCUS (Genetics)
KW - DEVELOPMENTAL biology
KW - CHEMICAL embryology
KW - REPRODUCTION
KW - MOLECULAR genetics
KW - Drosophila
KW - Promoter specificity
KW - Regulatory DNA
KW - Transcriptional control
N1 - Accession Number: 44046193; Kwon, Deborah 1 Mucci, Diane 2 Langlais, Kristofor K. 1 Americo, Jeffrey L. 1 DeVido, Sarah K. 1 Yuzhong Cheng 1 Kassis, Judith A. 1; Email Address: jkassis@mail.nih.gov; Affiliation: 1: Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 2: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; Source Info: Sep2009, Vol. 136 Issue 18, p4; Subject Term: DROSOPHILA; Subject Term: LOCUS (Genetics); Subject Term: DEVELOPMENTAL biology; Subject Term: CHEMICAL embryology; Subject Term: REPRODUCTION; Subject Term: MOLECULAR genetics; Author-Supplied Keyword: Drosophila; Author-Supplied Keyword: Promoter specificity; Author-Supplied Keyword: Regulatory DNA; Author-Supplied Keyword: Transcriptional control; Number of Pages: 1p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Gi Yun
AU - Jang, Hye In
AU - Hwang, In Gyun
AU - Rhee, Min Suk
T1 - Prevalence and classification of pathogenic Escherichia coli isolated from fresh beef, poultry, and pork in Korea
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/09/15/
VL - 134
IS - 3
M3 - Article
SP - 196
EP - 200
SN - 01681605
AB - Abstract: Foodborne diseases occur worldwide, including through the consumption of contaminated meat. This study was conducted to investigate the prevalence of Escherichia coli contamination in fresh beef, poultry, and pork, and to determine whether any isolated E. coli possessed genes associated with pathogenicity. Three thousand meat samples were collected from 2004 to 2006 and were tested for the presence of E. coli. Two hundred and seventy-three E. coli isolates were obtained from beef, poultry, and pork, resulting in an overall isolation rate of 9.1%. Of these isolates, 201 were obtained from 1350 pork samples (14.9%), followed by 41 of 900 poultry samples (4.6%) and 31 of 750 beef samples (4.1%). A total of 39 pathogenic E. coli isolates from the three meat types were categorized into three virulence groups, namely enterotoxigenic E. coli (43.6%), enterohemorrhagic E. coli (EHEC) (35.9%; 22.6% of beef, 7.3% of poultry, and 2.0% of pork), and enteropathogenic E. coli (20.5%). Fourteen strains were identified as belonging to the EHEC, which included O18, O136, O119, O86, O8, O111, O15, O128, and O6. This study demonstrated that pathogenic E. coli are found in meat in Korea, and could act as a transmission vehicle for human infection as suggested by the occurrence and classification of pathogenic E. coli in retail meats. Furthermore, the data from this study could be used in the risk assessment of foodborne illnesses linked to meat consumption. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Pathogenic bacteria
KW - Escherichia coli
KW - MICROBIOLOGY
KW - Foodborne diseases
KW - Bacterial genetics
KW - Health risk assessment
KW - Beer
KW - Pork -- Contamination
KW - Meat microbiology
KW - Meat inspection
KW - Korea
KW - Fresh meat
KW - Multiplex PCR
KW - O-serogroup
KW - Prevalence
N1 - Accession Number: 43869961; Lee, Gi Yun 1; Jang, Hye In 1; Hwang, In Gyun 2; Rhee, Min Suk 1; Email Address: rheems@korea.ac.kr; Affiliations: 1: Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, 5-1 Anam-dong, Sungbuk-gu, Seoul, 136-713, South Korea; 2: Division of Food Microbiology, Korea Food and Drug Administration, 5 Nokbon-dong, Eunpyung-gu, Seoul, 122-020, South Korea; Issue Info: Sep2009, Vol. 134 Issue 3, p196; Thesaurus Term: Pathogenic bacteria; Thesaurus Term: Escherichia coli; Thesaurus Term: MICROBIOLOGY; Thesaurus Term: Foodborne diseases; Thesaurus Term: Bacterial genetics; Thesaurus Term: Health risk assessment; Subject Term: Beer; Subject Term: Pork -- Contamination; Subject Term: Meat microbiology; Subject Term: Meat inspection; Subject: Korea; Author-Supplied Keyword: Fresh meat; Author-Supplied Keyword: Multiplex PCR; Author-Supplied Keyword: O-serogroup; Author-Supplied Keyword: Prevalence; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2009.06.013
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Tyurin, Vladimir A.
AU - Tyurina, Yulia Y.
AU - Jung, Mi-Yeon
AU - Tungekar, Muhammad A.
AU - Wasserloos, Karla J.
AU - Bayır, Hülya
AU - Greenberger, Joel S.
AU - Kochanek, Patrick M.
AU - Shvedova, Anna A.
AU - Pitt, Bruce
AU - Kagan, Valerian E.
T1 - Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Y1 - 2009/09/15/
VL - 877
IS - 26
M3 - Article
SP - 2863
EP - 2872
SN - 15700232
AB - Abstract: Oxidation of two anionic phospholipids – cardiolipin (CL) in mitochondria and phosphatidylserine (PS) in extramitochondrial compartments – is important signaling event, particularly during the execution of programmed cell death and clearance of apoptotic cells. Quantitative analysis of CL and PS oxidation products is central to understanding their molecular mechanisms of action. We combined the identification of diverse phospholipid molecular species by ESI-MS with quantitative assessments of lipid hydroperoxides using a fluorescence HPLC-based protocol. We characterized CL and PS oxidation products formed in a model system (cyt c/H2O2), in apoptotic cells (neurons, pulmonary artery endothelial cells) and mouse lung under inflammatory/oxidative stress conditions (hyperoxia, inhalation of single walled carbon nanotubes). Our results demonstrate the usefulness of this approach for quantitative assessments, identification of individual molecular species and structural characterization of anionic phospholipids that are involved in oxidative modification in cells and tissues. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CARDIOLIPIN
KW - PHOSPHATIDYLSERINES
KW - OXIDATION
KW - APOPTOSIS
KW - ELECTROSPRAY ionization mass spectrometry
KW - QUANTITATIVE chemical analysis
KW - HIGH performance liquid chromatography
KW - Apoptosis
KW - Cardiolipin
KW - Cytochrome c
KW - Mass-spectrometry
KW - Oxidative lipidomics
KW - Phosphatidylserine
KW - Phospholipid hydroperoxides
N1 - Accession Number: 43616458; Tyurin, Vladimir A. 1,2; Email Address: vtyurin@pitt.edu Tyurina, Yulia Y. 1,2 Jung, Mi-Yeon 1,2 Tungekar, Muhammad A. 1,2 Wasserloos, Karla J. 2 Bayır, Hülya 1,2,3 Greenberger, Joel S. 4 Kochanek, Patrick M. 3 Shvedova, Anna A. 5 Pitt, Bruce 2 Kagan, Valerian E. 1,2; Email Address: kagan@pitt.edu; Affiliation: 1: Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA 2: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA 3: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA 4: Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA 5: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA; Source Info: Sep2009, Vol. 877 Issue 26, p2863; Subject Term: CARDIOLIPIN; Subject Term: PHOSPHATIDYLSERINES; Subject Term: OXIDATION; Subject Term: APOPTOSIS; Subject Term: ELECTROSPRAY ionization mass spectrometry; Subject Term: QUANTITATIVE chemical analysis; Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cardiolipin; Author-Supplied Keyword: Cytochrome c; Author-Supplied Keyword: Mass-spectrometry; Author-Supplied Keyword: Oxidative lipidomics; Author-Supplied Keyword: Phosphatidylserine; Author-Supplied Keyword: Phospholipid hydroperoxides; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.jchromb.2009.03.007
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Barton, Mary B.
AU - Elmore, Joann G.
T1 - Pointing the Way to Informed Medical Decision Making: Test Characteristics of Clinical Breast Examination.
JO - JNCI: Journal of the National Cancer Institute
JF - JNCI: Journal of the National Cancer Institute
Y1 - 2009/09/16/
VL - 101
IS - 18
M3 - Editorial
SP - 1223
EP - 1225
SN - 00278874
AB - The authors emphasize the need for women to understand the risks, benefits and side effects associated with screening through clinical breast examination (CBE) and associated diagnoses in order to make informed medical decision making. They claim that the Breast and Cervical Cancer Detection Program cannot provide reliable estimates of sensitivity for CBE screens. They also refer to the way risk information is presented and cultural norms as important considerations when discussing risks to patients.
KW - BREAST exams
KW - RISK assessment
KW - DIAGNOSIS
KW - DECISION making
N1 - Accession Number: 44557705; Barton, Mary B. 1 Elmore, Joann G. 2; Email Address: jelmore@u.washington.edu; Affiliation: 1: Agency for Healthcare Research and Quality, Center for Primary Care, Prevention and Clinical Partnerships, Rockville, MD 2: Department of Medicine, University of Washington School of Medicine, Seattle, WA; Source Info: 9/16/2009, Vol. 101 Issue 18, p1223; Subject Term: BREAST exams; Subject Term: RISK assessment; Subject Term: DIAGNOSIS; Subject Term: DECISION making; Number of Pages: 3p; Document Type: Editorial
L3 - 10.1093/jnci/djp279
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44557705&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - WarfeI, Jason M.
AU - D'AgniIIo, Felice
T1 - Anthrax Lethal Toxin Enhances IKB Kinase Activation and Differentially Regulates Pro-inflammatory Genes in Human Endothelium.
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
Y1 - 2009/09/18/
VL - 284
IS - 38
M3 - Article
SP - 25761
EP - 25771
SN - 00219258
AB - Anthrax lethal toxin (LT) was previously shown to enhance transcriptional activity of NF-κB in tumor necrosis factor-α-activated primary human endothelial cells. Here we show that this LT-mediated increase in NF-κB activation is associated with the enhanced degradation of the inhibitory proteins IκBα and IKκBϵ but not IκB&3x20AC;. Moreover, this was accompanied by enhanced activation of the 1κB kinase complex (IKK), which is responsible for targeting IκB proteins for degradation. Importantly, LT enhancement of IicBa degradation was completely blocked by a selective IκKβ inhibitor, whereas IκBβ degradation was attenuated, suggesting a mechanistic link. Consistent with the above data, LT-cotreated cells show elevated phosphorylation of two IKK substrates, IκBα and p65, both of which were blocked by incubation with the IKKβ inhibitor. Consistent with NF-κB activation, LT increased transcription of the NF-κB regulated gene CD40. Conversely, LT inhibited transcription of another NF-κB-regulated gene, CCL2. This inhibition was linked to the LT-mediated suppression of another CCL2-regulating transcription factor, AP-1 (activator protein-1). These data suggest that LT-mediated enhancement of NF-κB is IKK-dependent, but importantly, the net effect of LT on the transcription of proinflammatory genes is driven by the cumulative effect of LT on the particular set of transcription factors that regulate a given promoter. Together, these findings provide new mechanistic insight on how LT may disrupt the host response to anthrax. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Biological Chemistry is the property of American Society for Biochemistry & Molecular Biology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTHRAX
KW - TOXINS
KW - TRANSCRIPTION factors
KW - CYTOKINES
KW - FOCAL adhesion kinase
KW - COLONY-stimulating factors (Physiology)
N1 - Accession Number: 44476242; WarfeI, Jason M. 1,2 D'AgniIIo, Felice 1; Email Address: felice.dagnillo@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA 2: Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D. C. 20007, USA; Source Info: 9/18/2009, Vol. 284 Issue 38, p25761; Subject Term: ANTHRAX; Subject Term: TOXINS; Subject Term: TRANSCRIPTION factors; Subject Term: CYTOKINES; Subject Term: FOCAL adhesion kinase; Subject Term: COLONY-stimulating factors (Physiology); Number of Pages: 11p; Document Type: Article
L3 - 10.1074/jbc.M109.036970
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44476242&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Moorthy, V.S.
AU - Diggs, C.
AU - Ferro, S.
AU - Good, M.F.
AU - Herrera, S.
AU - Hill, A.V.
AU - Imoukhuede, E.B.
AU - Kumar, S.
AU - Loucq, C.
AU - Marsh, K.
AU - Ockenhouse, C.F.
AU - Richie, T.L.
AU - Sauerwein, R.W.
T1 - Report of a Consultation on the Optimization of Clinical Challenge Trials for Evaluation of Candidate Blood Stage Malaria Vaccines, 18–19 March 2009, Bethesda, MD, USA
JO - Vaccine
JF - Vaccine
Y1 - 2009/09/25/
VL - 27
IS - 42
M3 - Proceeding
SP - 5719
EP - 5725
SN - 0264410X
AB - Abstract: Development and optimization of first generation malaria vaccine candidates has been facilitated by the existence of a well-established Plasmodium falciparum clinical challenge model in which infectious sporozoites are administered to human subjects via mosquito bite. While ideal for testing pre-erythrocytic stage vaccines, some researchers believe that the sporozoite challenge model is less appropriate for testing blood stage vaccines. Here we report a consultation, co-sponsored by PATH MVI, USAID, EMVI and WHO, where scientists from all institutions globally that have conducted such clinical challenges in recent years and representatives from regulatory agencies and funding agencies met to discuss clinical malaria challenge models. Participants discussed strengthening and harmonizing the sporozoite challenge model and considered the pros and cons of further developing a blood stage challenge possibly better suited for evaluating the efficacy of blood stage vaccines. This report summarizes major findings and recommendations, including an update on the Plasmodium vivax clinical challenge model, the prospects for performing experimental challenge trials in malaria endemic countries and an update on clinical safety data. While the focus of the meeting was on the optimization of clinical challenge models for evaluation of blood stage candidate malaria vaccines, many of the considerations are relevant for the application of challenge trials to other purposes. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Malaria vaccine
KW - Drug development
KW - Clinical trials
KW - Plasmodium falciparum
KW - Erythrocytes
KW - Maryland
KW - United States
KW - Clinical trial
KW - P. falciparum
KW - P. vivax
N1 - Accession Number: 44178434; Moorthy, V.S. 1,2; Email Address: moorthyv@who.int; Diggs, C. 3; Ferro, S. 4; Good, M.F. 5; Herrera, S. 6; Hill, A.V. 7; Imoukhuede, E.B. 8; Kumar, S. 9; Loucq, C. 4; Marsh, K. 10; Ockenhouse, C.F. 11; Richie, T.L. 11; Sauerwein, R.W. 12; Affiliations: 1: Initiative for Vaccine Research, Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland; 2: Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK; 3: Malaria Vaccine Development Program, US Agency for International Development, Washington, DC, United States; 4: PATH Malaria Vaccine Initiative, Bethesda, MD, United States; 5: The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; 6: Immunology Institute, School of Health, Universidad del Valle, Cali, Colombia; 7: The Jenner Institute, University of Oxford, Oxford, UK; 8: European Malaria Vaccine Initiative, Copenhagen, Denmark; 9: Food and Drug Administration, Rockville, MD, United States; 10: KEMRI-Wellcome Research Programme, Kilifi, Kenya; 11: United States Military Malaria Vaccine Program, Silver Spring, MD, United States; 12: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Issue Info: Sep2009, Vol. 27 Issue 42, p5719; Thesaurus Term: Communicable diseases; Subject Term: Malaria vaccine; Subject Term: Drug development; Subject Term: Clinical trials; Subject Term: Plasmodium falciparum; Subject Term: Erythrocytes; Subject: Maryland; Subject: United States; Author-Supplied Keyword: Clinical trial; Author-Supplied Keyword: P. falciparum; Author-Supplied Keyword: P. vivax; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 7p; Document Type: Proceeding
L3 - 10.1016/j.vaccine.2009.07.049
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44178434&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sauder, Christian J.
AU - Zhang, Cheryl X.
AU - Link, Malen A.
AU - Duprex, W. Paul
AU - Carbone, Kathryn M.
AU - Rubin, Steven A.
T1 - Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence
JO - Vaccine
JF - Vaccine
Y1 - 2009/09/25/
VL - 27
IS - 42
M3 - Article
SP - 5822
EP - 5829
SN - 0264410X
AB - Abstract: The recent global resurgence of mumps has drawn attention to the continued need for robust mumps immunization programs. Unfortunately, some vaccines derived from inadequately attenuated vaccine strains of mumps virus have caused meningitis in vaccinees, leading to withdrawal of certain vaccine strains from the market, public resistance to vaccination, or in some cases, cessation of national mumps vaccination programs. The most widely implicated mumps vaccine in cases of postvaccination meningitis is derived from the Urabe AM9 strain, which remains in use in some countries. The Urabe AM9 vaccine virus has been shown to exhibit a considerable degree of nucleotide and amino acid heterogeneity. Some studies have specifically implicated variants containing a lysine residue at amino acid position 335 in the hemagglutinin-neuraminidase (HN) protein with neurotoxicity, whereas a glutamic acid residue at this position was associated with attenuation. To test this hypothesis we generated two modified Urabe AM9 cDNA clones coding either for a lysine or a glutamic acid at position 335 in the HN gene. The two viruses were rescued by reverse genetics and characterized in vitro and in vivo. Both viruses exhibited similar growth kinetics in neuronal and non-neuronal cell lines and were of similar neurotoxicity when tested in rats, suggesting that amino acid 335 is not a crucial determinant of Urabe AM9 growth or neurovirulence. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Hemagglutinin
KW - Glutamic acid
KW - Organic acids
KW - Mumps
KW - Neurotoxicology
KW - Lysine
KW - Immunization of children
KW - Neuraminidase
KW - Meningitis
KW - Mumps virus
KW - Neurovirulence
KW - Urabe AM9 vaccine
N1 - Accession Number: 44178453; Sauder, Christian J. 1; Email Address: christian.sauder@fda.hhs.gov; Zhang, Cheryl X. 1; Link, Malen A. 1; Duprex, W. Paul 2; Carbone, Kathryn M. 3; Rubin, Steven A. 1; Affiliations: 1: DVP/Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA; 2: School of Biomedical Sciences, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom; 3: National Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA; Issue Info: Sep2009, Vol. 27 Issue 42, p5822; Thesaurus Term: VACCINATION; Thesaurus Term: Hemagglutinin; Thesaurus Term: Glutamic acid; Thesaurus Term: Organic acids; Subject Term: Mumps; Subject Term: Neurotoxicology; Subject Term: Lysine; Subject Term: Immunization of children; Subject Term: Neuraminidase; Subject Term: Meningitis; Author-Supplied Keyword: Mumps virus; Author-Supplied Keyword: Neurovirulence; Author-Supplied Keyword: Urabe AM9 vaccine; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.07.051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44178453&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cho, Minjung
AU - Cho, Wan-Seob
AU - Choi, Mina
AU - Kim, Sueng Jun
AU - Han, Beom Seok
AU - Kim, Sheen Hee
AU - Kim, Hyoung Ook
AU - Sheen, Yhun Yhong
AU - Jeong, Jayoung
T1 - The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/09/28/
VL - 189
IS - 3
M3 - Article
SP - 177
EP - 183
SN - 03784274
AB - Abstract: Many approaches for the application of nano-sized particles to the human body as nanotechnology have been recently developed. The size of nanoparticles is related to their useful character and also plays a key role in toxicity. Since this surface area can interact with biological components of cells, nanoparticles can be more reactive in than larger particles. In the present study, a fluorescence dye-labeled 50, 100 and 200nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo. Incidence and severity of inflammatory response was transiently increased with injection of 200 and 100nm silica nanoparticles within 12h. But there was no significant response related to injection of 50nm particles. The silica particles of 50, 100 and 200nm were cleared via urine and bile. The 50nm silica nanoparticles cleared to urine and bile than 100nm and particles of 200nm existed at lower concentration than other two smaller particles in urine and feces. Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGY
KW - Nanotechnology
KW - Particle size determination
KW - Toxicology -- Dose-response relationship
KW - Intravenous injections
KW - Silica
KW - Nanoparticles
KW - Biophysical labeling
KW - Inflammation -- Immunological aspects
KW - Macrophages
KW - Spleen
KW - Liver
KW - Elimination
KW - Intravenous injection
KW - Particle size
KW - Silica nanoparticles
KW - Tissue distribution
N1 - Accession Number: 43307350; Cho, Minjung 1,2; Cho, Wan-Seob 1,3; Choi, Mina 1; Kim, Sueng Jun 1; Han, Beom Seok 1; Kim, Sheen Hee 1; Kim, Hyoung Ook 1; Sheen, Yhun Yhong 2; Jeong, Jayoung 1; Email Address: jjy_kfda@kfda.go.kr; Affiliations: 1: Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung-ku, Seoul 122-704, Republic of Korea; 2: College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Sudaemun-ku, Seoul 120-750, Republic of Korea; 3: ELEGI/Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; Issue Info: Sep2009, Vol. 189 Issue 3, p177; Thesaurus Term: TOXICOLOGY; Thesaurus Term: Nanotechnology; Thesaurus Term: Particle size determination; Thesaurus Term: Toxicology -- Dose-response relationship; Subject Term: Intravenous injections; Subject Term: Silica; Subject Term: Nanoparticles; Subject Term: Biophysical labeling; Subject Term: Inflammation -- Immunological aspects; Subject Term: Macrophages; Subject Term: Spleen; Subject Term: Liver; Author-Supplied Keyword: Elimination; Author-Supplied Keyword: Intravenous injection; Author-Supplied Keyword: Particle size; Author-Supplied Keyword: Silica nanoparticles; Author-Supplied Keyword: Tissue distribution; NAICS/Industry Codes: 541711 Research and Development in Biotechnology; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxlet.2009.04.017
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=43307350&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lee, Taekhee
AU - Chisholm, William P.
AU - Slaven, James E.
AU - Harper, Martin
T1 - Size Distributions of 0.5 to 20 µm Aerodynamic Diameter Lead-Containing Particles from Aerosol Sampler Walls and Filters.
JO - Aerosol Science & Technology
JF - Aerosol Science & Technology
Y1 - 2009/10//
VL - 43
IS - 10
M3 - Article
SP - 1042
EP - 1050
SN - 02786826
AB - The study presented here investigates the number weighted particle size distributions of aerosols generated in the laboratory from lead oxide and lead sulfide dusts and sampled by Institute of Occupational Medicine (IOM) and closed face cassette (CFC) samplers as determined by scanning electron microscopy (SEM). The wall deposits and filter deposits from each sampler were characterized separately. A Mann-Whitney statistical analysis revealed that differences in the number weighted distributions of particles captured by the filter and the wall were not significant over the size range (up to 20 µm aerodynamic equivalent diameter) present in these laboratory-generated aerosols. Furthermore, for these samples it was not possible to distinguish an absolute difference between the IOM and CFC filter catches. By comparing direct measurements of aerodynamic equivalent diameter (AED) made by an Aerodynamic Particle Sizer (APS) to AEDs calculated from SEM images, empirical shape factors for lead oxide and lead sulfide were determined. To validate this approach APS and SEM measurements of the AED of 2 µm and 6 µm physical diameter monodisperse glass and polystyrene microspheres were made. Using the shape factors of spheres and the known densities of these materials, it was found that the SEM determinations of AED agreed with the APS results. To demonstrate the reliability of the redeposition method of sample preparation, lead sulfide and lead oxide aerosols were briefly sampled by IOM samplers such that sufficient particles were collected for SEM examination directly on the filter but not so many that particles were likely to touch or overlap. Half of each filter was analyzed in the SEM directly; the other half was ultrasonically removed and re-deposited for analysis by SEM. There were no statistically significant differences in their number weighted size distributions, demonstrating that the sample treatment process does not change the size distribution of these particular aerosols. [ABSTRACT FROM AUTHOR]
AB - Copyright of Aerosol Science & Technology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICLE size distribution
KW - AEROSOLS (Sprays) -- Research
KW - PARTICLES
KW - RESEARCH
KW - SCANNING electron microscopy
KW - PARTICLE size determination -- Instruments
KW - LEAD compounds
N1 - Accession Number: 52838992; Lee, Taekhee 1 Chisholm, William P. 1; Email Address: wchisholm@cdc.gov Slaven, James E. 2 Harper, Martin 1; Affiliation: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; Source Info: Oct2009, Vol. 43 Issue 10, p1042; Subject Term: PARTICLE size distribution; Subject Term: AEROSOLS (Sprays) -- Research; Subject Term: PARTICLES; Subject Term: RESEARCH; Subject Term: SCANNING electron microscopy; Subject Term: PARTICLE size determination -- Instruments; Subject Term: LEAD compounds; Number of Pages: 9p; Illustrations: 2 Diagrams, 6 Graphs; Document Type: Article
L3 - 10.1080/02786820903134143
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=52838992&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wollscheid, Kristine A.
AU - Kremzner, Mary E.
T1 - Electronic cigarettes: Safety concerns and regulatory issues.
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
Y1 - 2009/10//10/1/2009
VL - 66
IS - 19
M3 - Opinion
SP - 1740
EP - 1742
PB - American Society of Health System Pharmacists
SN - 10792082
AB - In this article the author focuses the issues concerning the safety and regulatory of electronic cigarettes in the U.S. It presents the design of the electronic cigarette which comprises of three general components which include a nicotine cartridge, a smart chip and an atomization chamber. It suggests health care providers to advise cigarette smokers that electronic cigarettes are not a proven alternative to conventional cigarettes thus, the use of this product is highly discouraged
KW - CIGARETTES
KW - CIGARETTE smokers
KW - HEALTH
KW - HEALTH behavior
KW - CIGARETTE industry
KW - UNITED States
N1 - Accession Number: 44285271; Wollscheid, Kristine A. 1; Email Address: kristine.wollscheid@fda.hhs.gov Kremzner, Mary E. 1; Affiliation: 1: Food and Drug Administration, Silver Spring, MD; Source Info: 10/1/2009, Vol. 66 Issue 19, p1740; Subject Term: CIGARETTES; Subject Term: CIGARETTE smokers; Subject Term: HEALTH; Subject Term: HEALTH behavior; Subject Term: CIGARETTE industry; Subject Term: UNITED States; NAICS/Industry Codes: 312220 Tobacco product manufacturing; NAICS/Industry Codes: 453991 Tobacco Stores; NAICS/Industry Codes: 424940 Tobacco and Tobacco Product Merchant Wholesalers; NAICS/Industry Codes: 453999 All other miscellaneous store retailers (except beer and wine-making supplies stores); NAICS/Industry Codes: 413310 Cigarette and tobacco product merchant wholesalers; NAICS/Industry Codes: 312230 Tobacco Manufacturing; Number of Pages: 3p; Document Type: Opinion
L3 - 10.2146/ajhp090127
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44285271&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105319629
T1 - Electronic cigarettes: safety concerns and regulatory issues [corrected] [published erratum appears in AM J HEALTH SYST PHARM AJHP 2009 Nov 1;66(21):1900].
AU - Wollscheid KA
AU - Kremzner ME
Y1 - 2009/10//10/1/2009
N1 - Accession Number: 105319629. Language: English. Entry Date: 20091023. Revision Date: 20150711. Publication Type: Journal Article; pictorial. Journal Subset: Biomedical; Blind Peer Reviewed; Peer Reviewed; USA. Special Interest: Public Health. NLM UID: 9503023.
KW - Drug Delivery Systems
KW - Nicotine -- Administration and Dosage
KW - Smoking Cessation
KW - Device Approval
KW - Tobacco -- Legislation and Jurisprudence -- United States
KW - United States
KW - United States Food and Drug Administration
SP - 1740
EP - 1742
JO - American Journal of Health-System Pharmacy
JF - American Journal of Health-System Pharmacy
JA - AM J HEALTH SYST PHARM AJHP
VL - 66
IS - 19
CY - Bethesda, Maryland
PB - American Society of Health System Pharmacists
SN - 1079-2082
AD - Food and Drug Administration, Silver Spring, MD 20993, USA; kristine.wollscheid@fda.hhs.gov
U2 - PMID: 19767381.
DO - 10.2146/ajhp090127
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105319629&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Waters, Martha A.
AU - Grajewski, Barbara
AU - Pinkerton, Lynne E.
AU - Hein, Misty J.
AU - Zivkovich, Zachary
T1 - Development of Historical Exposure Estimates of Cosmic Radiation and Circadian Rhythm Disruption for Cohort Studies of Pan Am Flight Attendants.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/10//
VL - 52
IS - 10
M3 - Article
SP - 751
EP - 761
SN - 02713586
AB - The article describes the methods to estimate exposure to cosmic radiation and circadian disruption for flight attendants. It develops a method for estimating cosmic radiation effective doses and two metrics for circadian rhythm disruption for each subject. It concludes that the domicile-exposure matrix is used to calculate exposure estimates for a cohort mortality study of former flight attendants.
KW - Occupational diseases
KW - HEALTH
KW - Cosmic background radiation
KW - Effect of chemicals on circadian rhythms
KW - Occupational mortality
KW - Flight attendants
KW - Radiation -- Dosage
KW - Radiation dosimetry
KW - Cohort analysis
KW - aircraft
KW - cosmic radiation
KW - exposure assessment
KW - flight attendants
KW - flight crew
KW - retrospective
N1 - Accession Number: 44494743; Waters, Martha A. 1; Grajewski, Barbara 1; Pinkerton, Lynne E. 1; Email Address: bag2@cdc.gov; Hein, Misty J. 1; Zivkovich, Zachary 1; Affiliations: 1: Division at Surveillance, Hazard Evaluations, and Field Studies, National Institute tar Occupational Safety and Health (NIOSH), Cincinnati, OH; Issue Info: Oct2009, Vol. 52 Issue 10, p751; Thesaurus Term: Occupational diseases; Thesaurus Term: HEALTH; Subject Term: Cosmic background radiation; Subject Term: Effect of chemicals on circadian rhythms; Subject Term: Occupational mortality; Subject Term: Flight attendants; Subject Term: Radiation -- Dosage; Subject Term: Radiation dosimetry; Subject Term: Cohort analysis; Author-Supplied Keyword: aircraft; Author-Supplied Keyword: cosmic radiation; Author-Supplied Keyword: exposure assessment; Author-Supplied Keyword: flight attendants; Author-Supplied Keyword: flight crew; Author-Supplied Keyword: retrospective; NAICS/Industry Codes: 541380 Testing Laboratories; Number of Pages: 11p; Illustrations: 5 Charts, 2 Graphs; Document Type: Article
L3 - 10.1002/ajim.20738
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44494743&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Radon, Katja
AU - Ehrenstein, Vera
AU - Bigaignon-Cantineau, Janine
AU - Vellore, Arun Dev
AU - Fingerhut, Marilyn
AU - Nowak, Dennis
T1 - Occupational Health Crossing Borders—Part 1: Concept, Teaching Methods, and User Evaluation of the First International Summer School in Munich, Germany.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/10//
VL - 52
IS - 10
M3 - Article
SP - 774
EP - 781
SN - 02713586
AB - The article focuses on a summer course which aims to train healthcare professional working in occupational health (OH) in low- and middle-income countries. The course highlights the practical OH aspects instead of research methods for OH. The first part of this paper describes the course structure, teaching concept and participants, while the second part illustrates the content of the course by comparing OH safety in 18 countries worldwide.
KW - Industrial hygiene
KW - Occupational diseases
KW - Occupational health services
KW - Medical personnel -- Training of
KW - Curricula (Courses of study)
KW - developed countries
KW - developing countries
KW - international educational exchange
KW - occupational accidents
KW - occupational health
KW - teaching
N1 - Accession Number: 44494745; Radon, Katja 1; Email Address: katjasadon@med.lmu.de; Ehrenstein, Vera 1,2; Bigaignon-Cantineau, Janine 3; Vellore, Arun Dev 4; Fingerhut, Marilyn 5; Nowak, Dennis 1; Affiliations: 1: Unit for Occupational and Environmental Epidemiology & Net Teaching, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Clinical Centre of the Ludwig-Maximilians-University Munich, Munich, Germany; 2: Department of Clinical Epidemiology, Aarhus University Hospital, Science Centre Skejby, Aarhus N, Denmark; 3: Occupational Diseases and Occupational Health Department, Civil Hospital Strasbourg, Strasbourg, France; 4: Occupational Lung Disease Unit, Heart of England NHS Trust, Birmingham Heartlands Hospital, Birmingham, UK; 5: National Institute of Occupational Safety and Health, Washington, District 01 Columbia; Issue Info: Oct2009, Vol. 52 Issue 10, p774; Thesaurus Term: Industrial hygiene; Thesaurus Term: Occupational diseases; Subject Term: Occupational health services; Subject Term: Medical personnel -- Training of; Subject Term: Curricula (Courses of study); Author-Supplied Keyword: developed countries; Author-Supplied Keyword: developing countries; Author-Supplied Keyword: international educational exchange; Author-Supplied Keyword: occupational accidents; Author-Supplied Keyword: occupational health; Author-Supplied Keyword: teaching; NAICS/Industry Codes: 621399 Offices of All Other Miscellaneous Health Practitioners; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1002/ajim.20734
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44494745&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Mei Lin Wang
AU - Avashia, Bipin H.
AU - Petsonk, Edward L.
T1 - Interpreting Longitudinal Spirometry: Weight Gain and Other Factors Affecting the Recognition of Excessive FEV1 Decline.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/10//
VL - 52
IS - 10
M3 - Article
SP - 782
EP - 789
SN - 02713586
AB - The article focuses on a study which examines factors that affect the interpretation of forced expiratory volume (FEV). The study examines the impact of these factors on FEV measurement with the use of medical screening data collected in chemical plant workers between 1973 and 2003. Quantitative estimates of the effect of these factors on FEV are discovered and believed useful in the evaluation of lung function declines.
KW - Occupational diseases
KW - Industrial hygiene
KW - Health risk assessment
KW - Chemical plants
KW - Lung diseases -- Diagnosis
KW - Medical screening
KW - Industrial workers
KW - excessive FEV1 decline
KW - longitudinal data
KW - mass screening
KW - mixed model
KW - spirometry
N1 - Accession Number: 44494746; Mei Lin Wang 1; Avashia, Bipin H. 2; Petsonk, Edward L. 1; Email Address: elp2@cdc.gov; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (COG), Morgantown, West Virginia; 2: Institute Plant, Medical Department,West Virginia; Issue Info: Oct2009, Vol. 52 Issue 10, p782; Thesaurus Term: Occupational diseases; Thesaurus Term: Industrial hygiene; Thesaurus Term: Health risk assessment; Thesaurus Term: Chemical plants; Subject Term: Lung diseases -- Diagnosis; Subject Term: Medical screening; Subject Term: Industrial workers; Author-Supplied Keyword: excessive FEV1 decline; Author-Supplied Keyword: longitudinal data; Author-Supplied Keyword: mass screening; Author-Supplied Keyword: mixed model; Author-Supplied Keyword: spirometry; NAICS/Industry Codes: 236210 Industrial Building Construction; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 621999 All Other Miscellaneous Ambulatory Health Care Services; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1002/ajim.20727
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44494746&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Aspinall, Sherrie L.
AU - Banthin, Jessica S.
AU - Good, Chester B.
AU - Miller, G. Edward
AU - Cunningham, Francesca E.
T1 - VA Pharmacy Users: How They Differ From Other Veterans.
JO - American Journal of Managed Care
JF - American Journal of Managed Care
Y1 - 2009/10//
VL - 15
IS - 10
M3 - Article
SP - 701
EP - 708
SN - 10880224
AB - Objective: To compare users and nonusers of Veterans Affairs (VA) pharmacy services by age group. Study Design: Cross-sectional. Methods: We used data on sociodemographics, health status, and medical conditions from the Medical Expenditure Panel Survey (MEPS) to compare users and nonusers of VA pharmacies for medications. Data were pooled for 2003-2005 to ensure adequate sample sizes. Student t tests were used to compare the means for each variable, and all analyses were adjusted for the complex sample design of the MEPS. Results: Among both nonelderly (18-64 years) and elderly (>65 years) veterans, a higher proportion who used VA pharmacy services versus those who did not use VA pharmacy services (1) were black (nonelderly: 17.7 % vs 7.4%, P <.001; elderly: 9.4% vs 4.7%, P <.001); (2) had no alternative insurance (nonelderly: 27.2% vs 4.8%, P <.001; elderly: 36.3% vs 19.9%, P <.001); (3) had lower incomes (nonelderly: 32.4% vs 11.5%, P <.001; elderly: 32.4% vs 25.4%, P = .01); (4) had less than a high school education (nonelderly: 13.0% vs 6.5%, P <.001; elderly: 27.5% vs 17.6%, P <.001); (5) were disabled; and (6) reported poorer health. A higher percentage of nonelderly users reported a mental health condition (31.6% vs 19.4%, P <.001). Conclusions: Veterans who use VA pharmacy services appear to be more ill than those who do not use VA pharmacy services. In addition, the VA appears to be a safety net for uninsured veterans who have mental health problems. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Managed Care is the property of Intellisphere, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL care of veterans
KW - MEDICAL care costs
KW - HEALTH surveys
KW - OLDER people -- Health
KW - CROSS-sectional method
KW - UNITED States
KW - UNITED States. Dept. of Veterans Affairs
N1 - Accession Number: 44785051; Aspinall, Sherrie L. 1,2,3 Banthin, Jessica S. 4 Good, Chester B. 1,2,3,5 Miller, G. Edward 4 Cunningham, Francesca E. 1; Affiliation: 1: VA Center for Medication Safety, Hines, IL 2: Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 3: School of Pharmacy, University of Pittsburgh, PA 4: Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Washington, DC 5: School of Medicine, University of Pittsburgh, P; Source Info: Oct2009, Vol. 15 Issue 10, p701; Subject Term: MEDICAL care of veterans; Subject Term: MEDICAL care costs; Subject Term: HEALTH surveys; Subject Term: OLDER people -- Health; Subject Term: CROSS-sectional method; Subject Term: UNITED States; Company/Entity: UNITED States. Dept. of Veterans Affairs; NAICS/Industry Codes: 923140 Administration of Veterans' Affairs; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hellinger, Fred J.
T1 - The Effect of Certificate-of-Need Laws on Hospital Beds and Healthcare Expenditures: An Empirical Analysis.
JO - American Journal of Managed Care
JF - American Journal of Managed Care
Y1 - 2009/10//
VL - 15
IS - 10
M3 - Article
SP - 737
EP - 744
SN - 10880224
AB - Objective: To estimate the effect of certificateof- need legislation on hospital bed supply and healthcare expenditures. Study Design: This study uses state data on several variables, including healthcare expenditures, hospital bed supply, and the existence of a certificate-of-need program, from 4 periods (1985, 1990, 1995, and 2000). Methods: We estimate 2 multivariate regression equations. In the first equation, hospital bed supply is the dependent variable, and certificate of need is included as an independent variable. In the second equation, healthcare expenditures is the dependent variable, and hospital bed supply and certificate of need are included as independent variables. Results: Certificate-of-need laws have reduced the number of hospital beds by about 10% and have reduced healthcare expenditures by almost 2%. Certificate-of-need programs did not have a direct effect on healthcare expenditures. Conclusion: Certificate-of-need programs have limited the growth in the supply of hospital beds, and this has led to a slight reduction in the growth of healthcare expenditures. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Managed Care is the property of Intellisphere, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH facilities -- Certificates of need -- Law & legislation
KW - HOSPITAL beds
KW - HOSPITALS -- Furniture, equipment, etc.
KW - FINANCE
KW - EMPIRICAL research
KW - REGRESSION analysis
KW - MEDICAL care costs
N1 - Accession Number: 44785055; Hellinger, Fred J. 1; Email Address: fred.hellinger@ahrq.hhs.gov; Affiliation: 1: Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, MD; Source Info: Oct2009, Vol. 15 Issue 10, p737; Subject Term: HEALTH facilities -- Certificates of need -- Law & legislation; Subject Term: HOSPITAL beds; Subject Term: HOSPITALS -- Furniture, equipment, etc.; Subject Term: FINANCE; Subject Term: EMPIRICAL research; Subject Term: REGRESSION analysis; Subject Term: MEDICAL care costs; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339113 Surgical Appliance and Supplies Manufacturing; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; Number of Pages: 8p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105330809
T1 - The effect of certificate-of-need laws on hospital beds and healthcare expenditures: an empirical analysis.
AU - Hellinger FJ
Y1 - 2009/10//
N1 - Accession Number: 105330809. Language: English. Entry Date: 20091211. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 9613960.
KW - Bed Occupancy
KW - Health Care Costs -- Trends
KW - Legislation -- Evaluation -- United States
KW - Descriptive Statistics
KW - Income
KW - Mortality
KW - Multiple Regression
KW - United States
KW - Human
SP - 737
EP - 744
JO - American Journal of Managed Care
JF - American Journal of Managed Care
JA - AM J MANAGE CARE
VL - 15
IS - 10
CY - Plainsboro, New Jersey
PB - Intellisphere, LLC
AB - OBJECTIVE: To estimate the effect of certificate-of-need legislation on hospital bed supply and healthcare expenditures. STUDY DESIGN: This study uses state data on several variables, including healthcare expenditures, hospital bed supply, and the existence of a certificate-of-need program, from 4 periods (1985, 1990, 1995, and 2000). METHODS: We estimate 2 multivariate regression equations. In the first equation, hospital bed supply is the dependent variable, and certificate of need is included as an independent variable. In the second equation, healthcare expenditures is the dependent variable, and hospital bed supply and certificate of need are included as independent variables. RESULTS: Certificate-of-need laws have reduced the number of hospital beds by about 10% and have reduced healthcare expenditures by almost 2%. Certificate-of-need programs did not have a direct effect on healthcare expenditures. CONCLUSION: Certificate-of-need programs have limited the growth in the supply of hospital beds, and this has led to a slight reduction in the growth of healthcare expenditures.
SN - 1088-0224
AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Rd, Room 5319, Rockville, MD 20850; fred.hellinger@ahrq.hhs.gov
U2 - PMID: 19845425.
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DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Jagger, Janine
AU - Berguer, Ramon
AU - Gomaa, Ahmed E.
T1 - Study methods affect findings of safety trial of blunt suture needles
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
Y1 - 2009/10//
VL - 201
IS - 4
M3 - Letter
SP - e11
EP - e12
SN - 00029378
N1 - Accession Number: 44414351; Jagger, Janine 1; Email Address: jcj@virginia.edu; Berguer, Ramon 2; Gomaa, Ahmed E. 3; Source Information: Oct2009, Vol. 201 Issue 4, pe11; Number of Pages: 0p; Document Type: Letter
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DP - EBSCOhost
DB - hch
ER -
TY - JOUR
AU - Modric, Tomislav
AU - Mergia, Ayalew
T1 - The Use of Viral Vectors in Introducing Genes into Agricultural Animal Species.
JO - Animal Biotechnology
JF - Animal Biotechnology
Y1 - 2009/10//Oct-Dec2009
VL - 20
IS - 4
M3 - Article
SP - 216
EP - 230
PB - Taylor & Francis Ltd
SN - 10495398
AB - The use of viral vectors is a method for introducing foreign genes into various animal species. Vectors based on retro-, adeno-, flavi-, and parvoviruses have been used for research in animal species of agricultural importance, such as chickens, quail, swine, cows, goats, sheep, fish, crustaceans, and mollusks. Viral vectors allow for efficient transgenic integration into host genome or for transient expression of the transgenic construct in somatic tissues. Because of that, viral vectors are important tools for research and potentially other biotechnology applications such as improving animal production qualities and introducing disease resistance, thus improving food quality and safety. Other uses may include generating animal models of human diseases and using animals as bioreactors for production of therapeutic proteins. Each vector type provides a unique set of advantages and limitations, which are in some cases specific to an animal species or a method of introduction. This article discusses viral vector characteristics and potential applications in agriculturally important animal species. It discusses advantages and disadvantages of using viral vectors in genetic engineering of agricultural animals. [ABSTRACT FROM AUTHOR]
AB - Copyright of Animal Biotechnology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Livestock
KW - Animal models in research
KW - DNA viruses
KW - Animal species
KW - Animal genetic engineering
KW - Recombinant proteins
N1 - Accession Number: 44398630; Modric, Tomislav 1; Email Address: tomislav.modric@fda.hhs.gov; Mergia, Ayalew 2; Affiliations: 1: Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland, USA.; 2: Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainsville, Florida, USA.; Issue Info: Oct-Dec2009, Vol. 20 Issue 4, p216; Thesaurus Term: Livestock; Thesaurus Term: Animal models in research; Thesaurus Term: DNA viruses; Subject Term: Animal species; Subject Term: Animal genetic engineering; Subject Term: Recombinant proteins; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; Number of Pages: 15p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/10495390903196380
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Hanley, Kevin W.
AU - Petersen, Martin R.
AU - Cheever, Kenneth L.
AU - Luo, Lian
T1 - N-Acetyl-S-(n-Propyl)-L-Cysteine in Urine from Workers Exposed to 1-Bromopropane in Foam Cushion Spray Adhesives.
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
Y1 - 2009/10//
VL - 53
IS - 7
M3 - Article
SP - 759
EP - 769
SN - 00034878
AB - 1-Bromopropane (1-BP) has been marketed as an alternative for ozone depleting and other solvents; it is used in aerosol products, adhesives, metal, precision, and electronics cleaning solvents. Mechanisms of toxicity of 1-BP are not fully understood, but it may be a neurological and reproductive toxicant. Sparse exposure information prompted this study using 1-BP air sampling and urinary metabolites. Mercapturic acid conjugates are excreted in urine from 1-BP metabolism involving debromination. Research objectives were to evaluate the utility of urinary N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys) for assessing exposure to 1-BP and compare it to urinary bromide [Br(−)] previously reported for these workers. Forty-eight-hour urine specimens were obtained from 30 workers at two factories where 1-BP spray adhesives were used to construct polyurethane foam seat cushions. Urine specimens were also obtained from 21 unexposed control subjects. All the workers' urine was collected into composite samples representing three time intervals: at work, after work but before bedtime, and upon awakening. Time-weighted average (TWA) geometric mean breathing zone concentrations were 92.4 and 10.5 p.p.m. for spraying and non-spraying jobs, respectively. Urinary AcPrCys showed the same trend as TWA exposures to 1-BP: higher levels were observed for sprayers. Associations of AcPrCys concentrations, adjusted for creatinine, with 1-BP TWA exposure were statistically significant for both sprayers (P < 0.05) and non-sprayers (P < 0.01). Spearman correlation coefficients for AcPrCys and Br(−) analyses determined from the same urine specimens were highly correlated (P < 0.0001). This study confirms that urinary AcPrCys is an important 1-BP metabolite and an effective biomarker for highly exposed foam cushion workers. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BROMOPROPANE
KW - BROMINE compounds
KW - URINE
KW - ADHESIVES
KW - FOAM
KW - INDUSTRIAL hygiene
KW - INDUSTRIAL management
KW - METABOLITES
KW - BIOMOLECULES
KW - 1-bromopropane
KW - bromide
KW - CAS No. 106-94-5
KW - foam cushion
KW - N-acetyl-S-(n-propyl)-L-cysteine
KW - spray adhesive
KW - urine
N1 - Accession Number: 48718997; Hanley, Kevin W. 1; Email Address: KHanley@cdc.gov Petersen, Martin R. 1 Cheever, Kenneth L. 2 Luo, Lian 3; Affiliation: 1: Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. 2: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. 3: Constella Group, Inc., Cincinnati, Ohio.; Source Info: Oct2009, Vol. 53 Issue 7, p759; Subject Term: BROMOPROPANE; Subject Term: BROMINE compounds; Subject Term: URINE; Subject Term: ADHESIVES; Subject Term: FOAM; Subject Term: INDUSTRIAL hygiene; Subject Term: INDUSTRIAL management; Subject Term: METABOLITES; Subject Term: BIOMOLECULES; Author-Supplied Keyword: 1-bromopropane; Author-Supplied Keyword: bromide; Author-Supplied Keyword: CAS No. 106-94-5; Author-Supplied Keyword: foam cushion; Author-Supplied Keyword: N-acetyl-S-(n-propyl)-L-cysteine; Author-Supplied Keyword: spray adhesive; Author-Supplied Keyword: urine; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; NAICS/Industry Codes: 325520 Adhesive Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; Number of Pages: 11p; Illustrations: 1 Diagram, 4 Charts, 3 Graphs; Document Type: Article
L3 - 10.1093/annhyg/mep051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=48718997&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105229580
T1 - N-acetyl-S-(n-propyl)-l-cysteine in urine from workers exposed to 1-bromopropane in foam cushion spray adhesives.
AU - Hanley KW
AU - Petersen MR
AU - Cheever KL
AU - Luo L
Y1 - 2009/10//
N1 - Accession Number: 105229580. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0203526.
KW - Acetylcysteine
KW - Adhesives -- Metabolism
KW - Air Pollutants, Occupational -- Urine
KW - Bromides -- Urine
KW - Chromatography, High Pressure Liquid -- Methods
KW - Acetylcysteine -- Urine
KW - Adhesives
KW - Adult
KW - Biological Markers -- Urine
KW - Female
KW - Human
KW - Hydrocarbons, Brominated -- Metabolism
KW - Hydrocarbons, Brominated
KW - Male
KW - Mass Spectrometry -- Methods
SP - 759
EP - 769
JO - Annals of Occupational Hygiene
JF - Annals of Occupational Hygiene
JA - ANN OCCUP HYG
VL - 53
IS - 7
PB - Oxford University Press / USA
SN - 0003-4878
AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. KHanley@cdc.gov
U2 - PMID: 19706636.
DO - annhyg/mep051
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105229580&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105227405
T1 - Comparing generic and innovator drugs: a review of 12 years of bioequivalence data from the United States Food and Drug Administration.
AU - Davit BM
AU - Nwakama PE
AU - Buehler GJ
AU - Conner DP
AU - Haidar SH
AU - Patel DT
AU - Yang Y
AU - Yu LX
AU - Woodcock J
Y1 - 2009/10//
N1 - Accession Number: 105227405. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9203131.
KW - Drug Approval -- Legislation and Jurisprudence
KW - Drugs, Generic -- Pharmacokinetics
KW - Drug Administration
KW - Administration, Oral
KW - Pharmacokinetics
KW - Clinical Trials
KW - Drugs, Generic -- Economics
KW - Human
KW - Drugs -- Economics
KW - Drugs -- Metabolism
KW - Retrospective Design
KW - United States
KW - United States Food and Drug Administration
SP - 1583
EP - 1597
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
JA - ANN PHARMACOTHER
VL - 43
IS - 10
CY - Thousand Oaks, California
PB - Sage Publications Inc.
SN - 1060-0280
AD - Division of Bioequivalence II, Office of Generic Drugs, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, United States Food and Drug Administration, Derwood, MD 20855, USA. barbara.davit@fda.hhs.gov
U2 - PMID: 19776300.
DO - 10.1345/aph.1M141
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105227405&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105322907
T1 - Nursing, system design, and health care quality.
AU - Clancy CM
Y1 - 2009/10//
N1 - Accession Number: 105322907. Language: English. Entry Date: 20091204. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Patient Safety; Perioperative Care. NLM UID: 0372403.
KW - Health Care Errors -- Prevention and Control
KW - Perioperative Nursing
KW - Quality of Health Care
KW - Checklists
KW - Protocols
KW - Wrong Site Surgery -- Prevention and Control
SP - 581
EP - 583
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 90
IS - 4
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Director, Agency for Healthcare Research and Quality.
U2 - PMID: 19801010.
DO - 10.1016/j.aorn.2009.09.008
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105322907&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wang, Siyun
AU - Deng, Kaiping
AU - Zaremba, Sam
AU - Deng, Xiangyu
AU - Lin, Chiahui
AU - Wang, Qian
AU - Tortorello, Mary Lou
AU - Zhang, Wei
T1 - Transcriptomic Response of Escherichia coli O157:H7 to Oxidative Stress.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/10//
VL - 75
IS - 19
M3 - Article
SP - 6110
EP - 6123
SN - 00992240
AB - Chlorinated water is commonly used in industrial operations to wash and sanitize fresh-cut, minimally processed produce. Here we compared 42 human outbreak strains that represented nine distinct Escherichia coli O157:117 genetic lineages (or clades) for their relative resistance to chlorine treatment. A quantitative measurement of resistance was made by comparing the extension of the lag phase during growth of each strain under exposure to sublethal concentrations of sodium hypochlorite in Luria-Bertani or brain heart infusion broth. Strains in dade 8 showed significantly (P < 0.05) higher resistance to chlorine than strains from other clades of E. coli O157:H7. To further explore how E. coli O157:H7 responds to oxidative stress at transcriptional levels, we analyzed the global gene expression profiles of two strains, TW14359 (dade 8; associated with the 2006 spinach outbreak) and Sakai (dade 1; associated with the 1996 radish sprout outbreak), under sodium hypochlorite or hydrogen peroxide treatment. We found over 380 genes were differentially expressed (more than twofold; P < 0.05) after exposure to low levels of chlorine or hydrogen peroxide. Significantly upregulated genes included several regulatory genes responsive to oxidative stress, genes encoding putative oxidoreductases, and genes associated with cysteine biosynthesis, iron-sulfur cluster assembly, and antibiotic resistance. Identification of E. coli O157:117 strains with enhanced resistance to chlorine decontamination and analysis of their transcriptomic response to oxidative stress may improve our basic understanding of the survival strategy of this human enteric pathogen on fresh produce during minimal processing. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli -- Genetics -- Research
KW - OXIDATIVE stress
KW - WATER chlorination
KW - GENETIC transcription
KW - LINEAGE
KW - SODIUM hypochlorite
KW - HYDROGEN peroxide
KW - GENE expression
KW - OXIDOREDUCTASES
N1 - Accession Number: 47099743; Wang, Siyun 1 Deng, Kaiping 2 Zaremba, Sam 3 Deng, Xiangyu 1 Lin, Chiahui 1 Wang, Qian 1 Tortorello, Mary Lou 2 Zhang, Wei 1; Email Address: zhangw@iit.edu; Affiliation: 1: National Center for Food Safety and Technology, Illinois Institute of Technology, Chicago, Illinois 2: U.S. Food and Drug Administration, Summit Argo, Illinois 60501 3: Enteropathogen Resource Integration Center, SRA International, Rockville, Maryland 20852; Source Info: Oct2009, Vol. 75 Issue 19, p6110; Subject Term: ESCHERICHIA coli -- Genetics -- Research; Subject Term: OXIDATIVE stress; Subject Term: WATER chlorination; Subject Term: GENETIC transcription; Subject Term: LINEAGE; Subject Term: SODIUM hypochlorite; Subject Term: HYDROGEN peroxide; Subject Term: GENE expression; Subject Term: OXIDOREDUCTASES; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 14p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1128/AEM.00914-09
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Violanti, John M.
AU - Burchfiel, Cecil M.
AU - Hartley, Tara A.
AU - Mnatsakanova, Anna
AU - Fekedulegn, Desta
AU - Andrew, Michael E.
AU - Charles, Luenda E.
AU - Vila, Bryan J.
T1 - Atypical Work Hours and Metabolic Syndrome Among Police Officers.
JO - Archives of Environmental & Occupational Health
JF - Archives of Environmental & Occupational Health
Y1 - 2009///Fall2009
VL - 64
IS - 3
M3 - Article
SP - 194
EP - 201
PB - Taylor & Francis Ltd
SN - 19338244
AB - This study examined whether atypical work hours are associated with metabolic syndrome among a random sample of 98 police officers. Shift work and overtime data from daily payroll records and reported sleep duration were obtained. Metabolic syndrome was defined as elevated waist circumference and triglycerides, low HDL cholesterol, hypertension, and glucose intolerance. Multivariate analysis of variance and analysis of covariance models were used for analyses. Officers working midnight shifts were on average younger and had a slightly higher mean number of metabolic syndrome components. Stratification on sleep duration and overtime revealed significant associations between midnight shifts and the mean number of metabolic syndrome components among officers with less sleep (p = .013) and more overtime (p = .007). Results suggest shorter sleep duration and more overtime combined with midnight shift work may be important contributors to the metabolic syndrome. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Environmental & Occupational Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVERTIME
KW - SHIFT systems
KW - METABOLIC syndrome
KW - POLICE
KW - SLEEP
KW - MULTIVARIATE analysis
KW - ANALYSIS of covariance
KW - cardiovascular disease
KW - overtime
KW - police officers
KW - shift work
KW - sleep
N1 - Accession Number: 44874484; Violanti, John M. 1 Burchfiel, Cecil M. 2 Hartley, Tara A. 2 Mnatsakanova, Anna 2 Fekedulegn, Desta 2 Andrew, Michael E. 2 Charles, Luenda E. 2 Vila, Bryan J. 3; Affiliation: 1: Department of Social and Preventative Medicine, School of Public Health and Health Professions, State University of New York, Buffalo 2: Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 3: Criminal Justice Program and Sleep and Performance Research Center, Washington State University, Spokane, Washington; Source Info: Fall2009, Vol. 64 Issue 3, p194; Subject Term: OVERTIME; Subject Term: SHIFT systems; Subject Term: METABOLIC syndrome; Subject Term: POLICE; Subject Term: SLEEP; Subject Term: MULTIVARIATE analysis; Subject Term: ANALYSIS of covariance; Author-Supplied Keyword: cardiovascular disease; Author-Supplied Keyword: overtime; Author-Supplied Keyword: police officers; Author-Supplied Keyword: shift work; Author-Supplied Keyword: sleep; NAICS/Industry Codes: 922120 Police Protection; NAICS/Industry Codes: 913130 Municipal police services; NAICS/Industry Codes: 911230 Federal police services; NAICS/Industry Codes: 912130 Provincial police services; Number of Pages: 8p; Illustrations: 5 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lute, Scott
AU - Wang, Hua
AU - Sanchez, Davonie
AU - Barletta, Janet
AU - Chen, Qi
AU - Brorson, Kurt
T1 - Multiplex RT Q-PCR assay for simultaneous quantification of three viruses used for validation of virus clearance by biopharmaceutical production
JO - Biologicals
JF - Biologicals
Y1 - 2009/10//
VL - 37
IS - 5
M3 - Article
SP - 331
EP - 337
SN - 10451056
AB - Abstract: Virus removal studies are used to insure the safety of biopharmaceutical products by quantitatively estimating the viral clearance capacity by the manufacturing process. Virus quantification assays are used to measure the log10 clearance factor of individual purification unit operations in spike recovery studies. We have developed a multiplex RT Q-PCR assay that detects and quantifies three commonly used model viruses X-MuLV, SV40, and MMV simultaneously. This RT Q-PCR multiplex assay has a 6log10 dynamic range with a limit of detection (LOD) of ≈1 genome copy/μL. Amplification profiles are similar to existing singleplex assays. Overall, this RT Q-PCR multiplex assay is highly quantitative, accurately identifies multiple viruses simultaneously, and may prove useful to validate viral clearance of biological products in small scale studies. [Copyright &y& Elsevier]
AB - Copyright of Biologicals is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERASE chain reaction
KW - BIOLOGICAL assay
KW - BIOPHARMACEUTICS
KW - VIRUSES -- Identification
KW - VIRUS inactivation
KW - DRUGS -- Safety measures
KW - MANUFACTURING processes
KW - GENE amplification
KW - MONOCLONAL antibodies
KW - Monoclonal antibodies
KW - Q-PCR
KW - Viral safety
N1 - Accession Number: 44120330; Lute, Scott 1; Email Address: scott.lute@fda.hhs.gov Wang, Hua 2 Sanchez, Davonie 2 Barletta, Janet 1 Chen, Qi 2 Brorson, Kurt 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA 2: Late Stage Purification, Process Research and Development, Genentech Inc., One DNA Way, South San Francisco, CA 94080, USA; Source Info: Oct2009, Vol. 37 Issue 5, p331; Subject Term: POLYMERASE chain reaction; Subject Term: BIOLOGICAL assay; Subject Term: BIOPHARMACEUTICS; Subject Term: VIRUSES -- Identification; Subject Term: VIRUS inactivation; Subject Term: DRUGS -- Safety measures; Subject Term: MANUFACTURING processes; Subject Term: GENE amplification; Subject Term: MONOCLONAL antibodies; Author-Supplied Keyword: Monoclonal antibodies; Author-Supplied Keyword: Q-PCR; Author-Supplied Keyword: Viral safety; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 334513 Instruments and Related Products Manufacturing for Measuring, Displaying, and Controlling Industrial Process Variables; NAICS/Industry Codes: 333994 Industrial Process Furnace and Oven Manufacturing; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.biologicals.2009.07.002
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DP - EBSCOhost
DB - aph
ER -
TY - CONF
AU - Robertson, James S.
AU - Blümel, Johannes
AU - Brorson, Kurt
AU - Gröner, Albrecht
AU - Kreil, Thomas R.
AU - Ruiz, Sol
AU - Willkommen, Hannelore
T1 - Virus & TSE safety forum 2008
JO - Biologicals
JF - Biologicals
Y1 - 2009/10//
VL - 37
IS - 5
M3 - Proceeding
SP - 345
EP - 354
SN - 10451056
N1 - Accession Number: 44120332; Robertson, James S. 1; Email Address: jim.robertson@nibsc.hpa.org.uk Blümel, Johannes 2 Brorson, Kurt 3 Gröner, Albrecht 4 Kreil, Thomas R. 5 Ruiz, Sol 6 Willkommen, Hannelore 7; Affiliation: 1: National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK 2: Paul-Ehrlich-Institut, 63225 Langen, Germany 3: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903, USA 4: CSL Behring, 35041 Marburg, Germany 5: Global Pathogen Safety, Baxter BioScience, A-1221 Vienna, Austria 6: Spanish Medicines Agency (AEMPS), 28022 – Madrid, Spain 7: Regulatory Affairs & Biological Safety Consulting, Erzhausen, Germany; Source Info: Oct2009, Vol. 37 Issue 5, p345; Number of Pages: 10p; Document Type: Proceeding
L3 - 10.1016/j.biologicals.2009.05.001
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van der Borght, S.
AU - Janssens, V.
AU - Schim van der Loeff, M. F.
AU - Kajemba, A.
AU - Rijckborst, H.
AU - Lange, J. M. A
AU - Rinke de Wit, T. F.
T1 - The Accelerating Access Initiative: experience with a multinational workplace programme in Africa.
JO - Bulletin of the World Health Organization
JF - Bulletin of the World Health Organization
Y1 - 2009/10//
VL - 87
IS - 10
M3 - Article
SP - 794
EP - 798
PB - World Health Organization
SN - 00429686
AB - Problem A multinational company with operations in several African countries was committed to offer antiretroviral treatment to its employees and their dependants. Approach The Accelerating Access Initiative (AAI), an initiative of six pharmaceutical companies and five United Nations' agencies, offered the possibility of obtaining brand antiretroviral drugs (ARVs) at 10% of the commercial price. PharmAccess, a foundation aimed at removing barriers to AIDS treatment in Africa, helped to establish an HIV policy and treatment guidelines, and a workplace programme was rolled out from September 2001. Local setting Private sector employers in Africa are keen to take more responsibility in HIV prevention and AIDS care. An important hurdle for African employers remains the price and availability of ARVs. Relevant changes The programme encountered various hurdles, among them the need for multiple contracts with multiple companies, complex importation procedures, taxes levied on ARVs, lack of support from pharmaceutical companies in importation and transportation, slow delivery of the drugs, lack of institutional memory in pharmaceutical companies and government policies excluding the company from access to ARVs under the AAI. Lessons learned The launch of the AAI enabled this multinational company to offer access to ARVs to its employees and dependants. The private sector should have access to these discounted drugs under the AAI. A network of local AAI offices should be created to assist in logistics of drugs ordering, purchase and clearance. No taxes should be levied on ARVs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIRETROVIRAL agents
KW - INTERNATIONAL business enterprises
KW - EMPLOYEES
KW - MEDICAL care
KW - HIV-positive persons
KW - HIV infections -- Treatment
KW - HIV infections
KW - GOVERNMENT policy
KW - PUBLIC health -- Economic aspects
KW - THERAPEUTIC use
KW - EMPLOYMENT
KW - AFRICA
N1 - Accession Number: 44966699; Van der Borght, S. 1; Email Address: Stefaan.vanderBorght@heineken.com Janssens, V. 2 Schim van der Loeff, M. F. 3 Kajemba, A. 3 Rijckborst, H. 1 Lange, J. M. A 2 Rinke de Wit, T. F. 2; Affiliation: 1: Heineken International Health Affairs, Tweede Weteringplantsoen 21, 1017 ZD Amsterdam, Netherlands 2: PharmAccess Foundation, Amsterdam, Netherlands 3: GGD (Public health service), Amsterdam, Netherlands; Source Info: Oct2009, Vol. 87 Issue 10, p794; Subject Term: ANTIRETROVIRAL agents; Subject Term: INTERNATIONAL business enterprises; Subject Term: EMPLOYEES; Subject Term: MEDICAL care; Subject Term: HIV-positive persons; Subject Term: HIV infections -- Treatment; Subject Term: HIV infections; Subject Term: GOVERNMENT policy; Subject Term: PUBLIC health -- Economic aspects; Subject Term: THERAPEUTIC use; Subject Term: EMPLOYMENT; Subject Term: AFRICA; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 5p; Illustrations: 2 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Byrd, Kathy K.
AU - Holman, Robert C.
AU - Bruce, Michael G.
AU - Hennessy, Thomas W.
AU - Wenger, Jay D.
AU - Bruden, Dana L.
AU - Haberling, Dana L.
AU - Steiner, Claudia
AU - Cheek, James E.
T1 - Methicillin-Resistant Staphylococcus aureus-Associated Hospitalizations among the American Indian and Alaska Native Population.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/10//10/1/2009
VL - 49
IS - 7
M3 - Article
SP - 1009
EP - 1015
SN - 10584838
AB - Background. American Indians and Alaska Natives (AI/ANs) have had documented outbreaks of methicillinresistant Staphylococcus aureus (MRSA) infection but, to our knowledge, no studies have examined MRSA infection among this population nationally. We describe MRSA-associated hospitalizations among the ∼1.6 million AI/ANs who receive care at Indian Health Service health care facilities nationwide. Methods. We used hospital discharge data from the Indian Health Service National Patient Information Reporting System to determine the rate of MRSA-associated hospitalizations among AI/ANs who used Indian Health Service health care in 1996-2005 and in the comparison periods 1996-1998 and 2003-2005. Hospitalization rates among AI/ANs were examined by year, age group, sex, and region. MRSA-associated diagnoses were also examined. Rate comparisons were performed using Poisson regression analysis. Comparison of rates to those of the general United States population was made for 2003-2005 by means of the Nationwide Inpatient Sample. Results. Between comparison periods, the rate of MRSA-associated hospitalization increased from 4.6 to 50.6 hospitalizations per 100,000 AI/ANs, P < .01 increases in both sexes, all age groups, and all regions. By 2005, MRSA was the causative organism for the majority (52%) of all S. aureus-associated hospitalizations. The most common associated diagnosis was skin and soft-tissue infection, which accounted for 59% ofMRSA-associated diagnoses. In 2003-2005, the age-adjusted rate among AI/ANs was 58.8 hospitalizations per 100,000 persons, compared with 84.7 hospitalizations per 100,000 persons in the general US population. Conclusions. MRSA-associated hospitalizations have increased significantly among AI/ANs served by Indian Health Service health care facilities. Clinicians should have a high index of suspicion for MRSA infection in AI/ ANs, especially in those with a diagnosis of skin and soft-tissue infection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Staphylococcus aureus infections
KW - Medical care
KW - Methicillin resistance
KW - Native Americans
KW - Regression analysis
KW - Alaska Natives
KW - Alaska
KW - United States
N1 - Accession Number: 56106651; Byrd, Kathy K. 1,2; Email Address: gdn8@cdc.gov; Holman, Robert C. 3; Bruce, Michael G. 2; Hennessy, Thomas W. 2; Wenger, Jay D. 2; Bruden, Dana L. 2; Haberling, Dana L. 3; Steiner, Claudia 4; Cheek, James E. 5; Affiliations: 1: Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office; 2: Division of Emerging Infections and Surveillance Systems, National Center for Preparedness, Detection and Control of Infectious Diseases, CDC, USDHHS, Anchorage, Alaska; 3: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention (CDC), United States Department of Health and Human Services (USDHHS), Atlanta, Georgia; 4: Center for Delivery, Organization, and Markets, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, Rockville, Maryland; 5: Division of Epidemiology and Prevention, Office of Public Health Support, Indian Health Service, USDHHS, Albuquerque, New Mexico; Issue Info: 10/1/2009, Vol. 49 Issue 7, p1009; Subject Term: Staphylococcus aureus infections; Subject Term: Medical care; Subject Term: Methicillin resistance; Subject Term: Native Americans; Subject Term: Regression analysis; Subject Term: Alaska Natives; Subject: Alaska; Subject: United States; Number of Pages: 7p; Illustrations: 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1086/605560
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yorita Christensen, Krista L.
AU - Holman, Robert C.
AU - Steiner, Claudia A.
AU - Sejvar, James J.
AU - Stoll, Barbara J.
AU - Schonberger, Lawrence B.
T1 - Infectious Disease Hospitalizations in the United States.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/10//10/1/2009
VL - 49
IS - 7
M3 - Article
SP - 1025
EP - 1135
SN - 10584838
AB - Background. Infectious diseases (IDs) cause widespread morbidity and mortality.We describe the epidemiology of ID hospitalizations in the United States with use of a nationally representative database. Methods. First-listed ID hospitalizations in the United States were analyzed using the Nationwide Inpatient Sample for 1998-2006. Hospitalization rates were calculated overall for IDs and for specific ID groups. Results. An estimated 40,085,978 (standard error, 255,418) hospitalizations with a first-listed ID occurred during 1998-2006, for an age-adjusted hospitalization rate of 154.4 (95% confidence interval, 153.3-155.5) hospitalizations per 10,000 persons. The rate increased slightly over the study period (152.5 [95% confidence interval, 149.6-155.4] in 1998 vs 162.2 [95% confidence interval, 158.7-165.5] in 2006); an increase was seen for both sexes, for older patients, and for Hispanic patients. Among those aged 5-39 years, female patients had a significantly higher hospitalization rate than did male patients; male patients had higher rates among the youngest children and adults aged ⩾40 years. Approximately 4.5 million hospital days and $865 billion in hospital charges were associated with primary ID hospitalizations over the study period. Lower respiratory tract infections were the most commonly listed ID (34.4%), followed by kidney, urinary tract, and bladder infections; cellulitis; and abdominal and rectal infections. Conclusions. The ID hospitalization rate increased during 1998-2006, reflecting an increase in ID hospitalizations among adults aged ⩾30 years, particularly older adults. Differences in trends and patterns of ID hospitalizations were noted by sex, age group, and race. Lower respiratory tract infections accounted for the largest proportion of ID hospitalizations. Future efforts should focus on preventive measures and improving early interventions for IDs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Communicable diseases
KW - Diseases -- Causes & theories of causation
KW - Respiratory infections
KW - Hospital care
KW - United States
N1 - Accession Number: 56106654; Yorita Christensen, Krista L. 1; Email Address: KYorita@cdc.gov; Holman, Robert C. 1; Steiner, Claudia A. 2; Sejvar, James J. 1; Stoll, Barbara J. 3; Schonberger, Lawrence B. 1; Affiliations: 1: Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services; 2: Healthcare Cost and Utilization Project, Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, Maryland; 3: Children's Healthcare of Atlanta, Emory School of Medicine, Department of Pediatrics, Atlanta, Georgia; Issue Info: 10/1/2009, Vol. 49 Issue 7, p1025; Thesaurus Term: Communicable diseases; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Respiratory infections; Subject Term: Hospital care; Subject: United States; Number of Pages: 11p; Illustrations: 4 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/605562
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105231281
T1 - Examining Latino differences in mental healthcare use: the roles of acculturation and attitudes towards healthcare.
AU - Berdahl TA
AU - Torres Stone RA
Y1 - 2009/10//
N1 - Accession Number: 105231281. Language: English. Entry Date: 20100108. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Peer Reviewed. Special Interest: Psychiatry/Psychology. Grant Information: Agency for Healthcare Research and Quality, Rockville, MD.. NLM UID: 0005735.
KW - Acculturation
KW - Help Seeking Behavior -- Ethnology
KW - Hispanics
KW - Mental Health Services -- Utilization
KW - Adult
KW - Cross Sectional Studies
KW - Descriptive Research
KW - Descriptive Statistics
KW - Female
KW - Funding Source
KW - Logistic Regression
KW - Male
KW - Odds Ratio
KW - P-Value
KW - Questionnaires
KW - Sample Size
KW - Young Adult
SP - 393
EP - 403
JO - Community Mental Health Journal
JF - Community Mental Health Journal
JA - COMMUNITY MENT HEALTH J
VL - 45
IS - 5
CY - ,
PB - Springer Science & Business Media B.V.
AB - Latinos are less likely to use mental health services compared to non-Latino whites, but little research has examined the relative contribution of acculturation and attitudes towards healthcare. In the current study, we analyze data from a nationally representative sample of Mexicans, Cubans, Puerto Ricans and non-Latino whites from the 2002-2003 Medical Expenditure Panel Survey (n = 30,234). Findings show different utilization patterns in use of specialty, non-specialty, and any type of mental healthcare across the three Latino subgroups. The predictive efficacy of acculturation variables on ethnic group differences varies by subgroup. Self-reliant attitudes towards healthcare are associated with lower use, but these attitudes do not explain the ethnic gaps in use.
SN - 0010-3853
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Suite 5000, Rockville, MD 20850, USA. terceira.berdahl@ahrq.hhs.gov
U2 - PMID: 19690955.
DO - 10.1007/s10597-009-9231-6
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ghosh, Pulak
AU - Huang, Lan
AU - Yu, Binbing
AU - Tiwari, Ram C.
T1 - Semiparametric Bayesian approaches to joinpoint regression for population-based cancer survival data
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2009/10//
VL - 53
IS - 12
M3 - Article
SP - 4073
EP - 4082
SN - 01679473
AB - Abstract: According to the American Cancer Society report (1999), cancer surpasses heart disease as the leading cause of death in the United States of America (USA) for people of age less than 85. Thus, medical research in cancer is an important public health interest. Understanding how medical improvements are affecting cancer incidence, mortality and survival is critical for effective cancer control. In this paper, we study the cancer survival trend on the population level cancer data. In particular, we develop a parametric Bayesian joinpoint regression model based on a Poisson distribution for the relative survival. To avoid identifying the cause of death, we only conduct analysis based on the relative survival. The method is further extended to the semiparametric Bayesian joinpoint regression models wherein the parametric distributional assumptions of the joinpoint regression models are relaxed by modeling the distribution of regression slopes using Dirichlet process mixtures. We also consider the effect of adding covariates of interest in the joinpoint model. Three model selection criteria, namely, the conditional predictive ordinate (CPO), the expected predictive deviance (EPD), and the deviance information criteria (DIC), are used to select the number of joinpoints. We analyze the grouped survival data for distant testicular cancer from the Surveillance, Epidemiology, and End Results (SEER) Program using these Bayesian models. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MATHEMATICAL statistics
KW - NONPARAMETRIC statistics
KW - BAYESIAN analysis
KW - REGRESSION analysis
KW - SURVIVAL analysis (Biometry)
KW - HEART diseases
KW - MEDICAL research
KW - PUBLIC health
KW - UNITED States
KW - AMERICAN Cancer Society Inc.
N1 - Accession Number: 44100288; Ghosh, Pulak 1; Email Address: pulakghosh@gmail.com Huang, Lan 2 Yu, Binbing 3 Tiwari, Ram C. 4; Affiliation: 1: Department of Mathematics and Statistics, Georgia State University, Atlanta, USA 2: Statistical Research and Applications Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892-8317, USA 3: National Institute of Aging, Bethesda, MD 20892-8317, USA 4: Office of Biostatistics, Food and Drug Administration, Silver Spring, MD, USA; Source Info: Oct2009, Vol. 53 Issue 12, p4073; Subject Term: MATHEMATICAL statistics; Subject Term: NONPARAMETRIC statistics; Subject Term: BAYESIAN analysis; Subject Term: REGRESSION analysis; Subject Term: SURVIVAL analysis (Biometry); Subject Term: HEART diseases; Subject Term: MEDICAL research; Subject Term: PUBLIC health; Subject Term: UNITED States; Company/Entity: AMERICAN Cancer Society Inc.; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.csda.2009.04.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44100288&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Yousef, Waleed A.
AU - Kundu, Subrata
AU - Wagner, Robert F.
T1 - Nonparametric estimation of the threshold at an operating point on the ROC curve
JO - Computational Statistics & Data Analysis
JF - Computational Statistics & Data Analysis
Y1 - 2009/10//
VL - 53
IS - 12
M3 - Article
SP - 4370
EP - 4383
SN - 01679473
AB - Abstract: In the problem of binary classification (or medical diagnosis), the classification rule (or diagnostic test) produces a continuous decision variable which is compared to a critical value (or threshold). Test values above (or below) that threshold are called positive (or negative) for disease. The two types of errors associated with every threshold value are Type (false positive) and Type (false negative) errors. The Receiver Operating Curve (ROC) describes the relationship between probabilities of these two types of errors. The inverse problem is considered; i.e., given the ROC curve (or its estimate) of a particular classification rule, one is interested in finding the value of the threshold that leads to a specific operating point on that curve. A nonparametric method for estimating the threshold is proposed. Asymptotic distribution is derived for the proposed estimator. Results from simulated data and real-world data are presented for finite sample size. Finding a particular threshold value is crucial in medical diagnoses, among other fields, where a medical test is used to classify a patient as “diseased” or “nondiseased” based on comparing the test result to a particular threshold value. When the ROC is estimated, an operating point is obtained by fixing probability of one type of error, and obtaining the other one from the estimated curve. Threshold estimation can then be viewed as a quantile estimation for one distribution but with the utilization of the second one. [Copyright &y& Elsevier]
AB - Copyright of Computational Statistics & Data Analysis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NONPARAMETRIC statistics
KW - ESTIMATION theory
KW - DIAGNOSIS
KW - STATISTICAL decision making
KW - SIMULATION methods & models
KW - ASYMPTOTIC distribution (Probability theory)
KW - MEASUREMENT errors
KW - SENSITIVITY analysis
N1 - Accession Number: 44100315; Yousef, Waleed A. 1; Email Address: wyousef@Helwan.edu.eg Kundu, Subrata 2 Wagner, Robert F. 3; Affiliation: 1: Computer Science Department, Faculty of Computers and Information, Helwan University, Helwan 11795, Egypt 2: Department of Statistics, The George Washington University, Washington, DC 20052, USA 3: Food and Drug Administration (CDRH), Silver Spring, MD 20993, USA; Source Info: Oct2009, Vol. 53 Issue 12, p4370; Subject Term: NONPARAMETRIC statistics; Subject Term: ESTIMATION theory; Subject Term: DIAGNOSIS; Subject Term: STATISTICAL decision making; Subject Term: SIMULATION methods & models; Subject Term: ASYMPTOTIC distribution (Probability theory); Subject Term: MEASUREMENT errors; Subject Term: SENSITIVITY analysis; Number of Pages: 14p; Document Type: Article
L3 - 10.1016/j.csda.2009.06.006
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105271952
T1 - Recurrent episodes of serotonin-reuptake inhibitor-mediated hyponatremia in an elderly patient.
AU - Stovall R
AU - Brahm NC
AU - Crosby KM
Y1 - 2009/10//2009 Oct
N1 - Accession Number: 105271952. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; case study; research. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9013983.
KW - Inappropriate ADH Syndrome -- Chemically Induced
KW - Serotonin Uptake Inhibitors -- Adverse Effects
KW - Sulfur Compounds -- Adverse Effects
KW - Aged
KW - Antidepressive Agents -- Administration and Dosage
KW - Antidepressive Agents -- Adverse Effects
KW - Antidepressive Agents -- Therapeutic Use
KW - Depression -- Drug Therapy
KW - Dose-Response Relationship, Drug
KW - Female
KW - Human
KW - Inappropriate ADH Syndrome -- Diagnosis
KW - Recurrence
KW - Serotonin Uptake Inhibitors -- Administration and Dosage
KW - Serotonin Uptake Inhibitors -- Therapeutic Use
KW - Sodium -- Blood
KW - Sulfur Compounds -- Administration and Dosage
KW - Sulfur Compounds -- Therapeutic Use
SP - 765
EP - 768
JO - Consultant Pharmacist
JF - Consultant Pharmacist
JA - CONSULTANT PHARMACIST
VL - 24
IS - 10
CY - Alexandria, Virginia
PB - American Society of Consultant Pharmacists
SN - 0888-5109
AD - Okmulgee Indian Health Service, Okmulgee, Oklahoma, USA.
U2 - PMID: 20017411.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105271952&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bang, Ki Moon
AU - Syamlal, Girija
AU - Mazurek, Jacek M.
T1 - Prevalence of Chronic Obstructive Pulmonary Disease in the U.S. Working Population: An Analysis of Data from the 1997-2004 National Health Interview Survey.
JO - COPD: Journal of Chronic Obstructive Pulmonary Disease
JF - COPD: Journal of Chronic Obstructive Pulmonary Disease
Y1 - 2009/10//
VL - 6
IS - 5
M3 - Article
SP - 380
EP - 387
SN - 15412555
AB - To estimate the prevalence and the population attributable fraction of chronic obstructive pulmonary disease (COPD) in the U.S. adult workers, we analyzed data obtained from the National Health Interview Surveys for the period 1997-2004. The overall COPD prevalence was 4.0% (95% confidence interval [CI] 3.9-4.1%). The prevalence was higher in females (5.4%, 95% CI 5.3-5.6%) than in males (2.8%, 95% CI 2.7-2.9%); in Whites (4.2%, 95% CI 4.1-4.3%) than in Blacks (3.4%, 95% CI 3.1-3.7%) and other races (2.4%, 95% CI 2.1-2.8%). Compared with insurance, real estate and other finance industry, the top three industries associated with significantly higher prevalence odds ratios (PORs) (adjusted for age, sex, race, and smoking) were other educational services (POR = 1.5, 95% CI 1.0-2.3); transportation equipment (POR = 1.4, 95% CI 1.1-1.8); and social services, religious and membership organizations (POR = 1.4, 95% CI 1.1-1.7). Compared with managers and administrators, except public administration occupation, the top three occupations with significantly higher PORs were health service (1.8, 95% CI 1.5-2.1), other protective service (POR = 1.6, 95% CI 1.2-2.2), and material moving equipment operators (POR = 1.6, 95% CI 1.1-2.3). The overall population attributable fraction for association of COPD with employment was 12.2% for industry and 17.4% for occupation. Further studies are needed to determine specific risk factors associated with COPD in industries and occupations with elevated prevalence and POR. [ABSTRACT FROM AUTHOR]
AB - Copyright of COPD: Journal of Chronic Obstructive Pulmonary Disease is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OBSTRUCTIVE lung diseases
KW - RESEARCH
KW - DISEASE prevalence
KW - HEALTH
KW - OCCUPATIONAL diseases
KW - INDUSTRIAL hygiene
KW - SEX factors in disease
KW - HEALTH surveys -- United States
KW - OFFICIALS & employees
KW - UNITED States
KW - Chronic obstructive pulmonary disease
KW - Industry
KW - Occupation
KW - Prevalence
N1 - Accession Number: 44375607; Bang, Ki Moon 1; Email Address: kmb2@cdc.gov Syamlal, Girija 1; Email Address: GSyamal@cdc.gov Mazurek, Jacek M. 1; Email Address: ACQ8@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Centers of Disease Control and Prevention, Morgantown, West Virginia 26505, USA; Source Info: Oct2009, Vol. 6 Issue 5, p380; Subject Term: OBSTRUCTIVE lung diseases; Subject Term: RESEARCH; Subject Term: DISEASE prevalence; Subject Term: HEALTH; Subject Term: OCCUPATIONAL diseases; Subject Term: INDUSTRIAL hygiene; Subject Term: SEX factors in disease; Subject Term: HEALTH surveys -- United States; Subject Term: OFFICIALS & employees; Subject Term: UNITED States; Author-Supplied Keyword: Chronic obstructive pulmonary disease; Author-Supplied Keyword: Industry; Author-Supplied Keyword: Occupation; Author-Supplied Keyword: Prevalence; Number of Pages: 8p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1080/15412550903140899
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44375607&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wokovich, Anna
AU - Tyner, Katherine
AU - Doub, William
AU - Sadrieh, Nakissa
AU - Buhse, Lucinda F.
T1 - Particle size determination of sunscreens formulated with various forms of titanium dioxide.
JO - Drug Development & Industrial Pharmacy
JF - Drug Development & Industrial Pharmacy
Y1 - 2009/10//
VL - 35
IS - 10
M3 - Article
SP - 1180
EP - 1189
PB - Taylor & Francis Ltd
SN - 03639045
AB - Background: There has been some apprehension expressed in the scientific literature that nanometer-sized titanium dioxide (TiO2) and other nanoparticles, if able to penetrate the skin, may cause cytotoxicity. In light of a lack of data regarding dermal penetration of titanium dioxide from sunscreen formulations, the Food and Drug Administration Center for Drug Evaluation and Research initiated a study in collaboration with the National Center for Toxicology Research using minipigs to determine whether nanoscale TiO2 in sunscreen products can penetrate intact skin. Four sunscreen products were manufactured. Method: The particle size distribution of three TiO2 raw materials, a sunscreen blank (no TiO2) and three sunscreen formulations containing uncoated nanometer-sized TiO2, coated nanometer-sized TiO2 or sub-micron TiO2 were analyzed using scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM), and X-ray diffraction (XRD) to determine whether the formulation process caused a change in the size distributions (e.g., agglomeration or deagglomeration) of the TiO2. Results: SEM and XRD of the formulated sunscreens containing nanometer TiO2 show the TiO2 particles to have the same size as that observed for the raw materials. This suggests that the formulation process did not affect the size or shape of the TiO2 particles. Conclusion: Because of the resolution limit of optical microscopy, nanoparticles could not be accurately sized using LSCM, which allows for detection but not sizing of the particles. LSCM allows observation of dispersion profiles throughout the sample; therefore, LSCM can be used to verify that results observed from SEM experiments are not solely surface effects. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Development & Industrial Pharmacy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLINICAL drug trials
KW - TITANIUM dioxide
KW - DRUGS -- Toxicology
KW - TITANIUM group
KW - NANOPARTICLES
KW - Laser scanning confocal microscopy
KW - nanoparticle
KW - scanning electron microscopy
KW - titanium dioxide
N1 - Accession Number: 44285114; Wokovich, Anna 1; Email Address: anna.wokovich@fda.hhs.gov; Tyner, Katherine 2; Doub, William 1; Sadrieh, Nakissa 2; Buhse, Lucinda F. 1; Affiliations: 1: Food and Drug Administration, Center for Drug Evaluation and Research, St. Louis, MO, USA.; 2: Food and Drug Administration, Center for Drug Evaluation and Research, New Hampshire, Silver Spring, MD, USA.; Issue Info: Oct2009, Vol. 35 Issue 10, p1180; Subject Term: CLINICAL drug trials; Subject Term: TITANIUM dioxide; Subject Term: DRUGS -- Toxicology; Subject Term: TITANIUM group; Subject Term: NANOPARTICLES; Author-Supplied Keyword: Laser scanning confocal microscopy; Author-Supplied Keyword: nanoparticle; Author-Supplied Keyword: scanning electron microscopy; Author-Supplied Keyword: titanium dioxide; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 4 Black and White Photographs, 3 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/03639040902838043
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=44285114&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Winthrop, Kevin L.
AU - Chang, Eric
AU - Yamashita, Shellie
AU - Iademarco, Michael F.
AU - LoBue, Philip A.
T1 - Nontuberculous Mycobacteria Infections and Anti-Tumor Necrosis Factor-α Therapy.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/10//
VL - 15
IS - 10
M3 - Article
SP - 1556
EP - 1561
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - Patients receiving anti-tumor necrosis factor-α (anti-TNF-α) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. We reviewed the US Food and Drug Administration MedWatch database for reports of NTM disease in patients receiving anti-TNF-α therapy. Of 239 reports collected, 105 (44%) met NTM disease criteria. Median age was 62 years; the majority of patients (66, 65%) were female, and most (73, 70%) had rheumatoid arthritis. NTM infections were associated with infliximab (n = 73), etanercept (n = 25), and adalimumab (n = 7); most patients were taking prednisone (n = 68, 65%) or methotrexate (n = 58, 55%) concurrently. Mycobacteria avium (n = 52, 50%) was most commonly implicated, and 9 patients (9%) had died at the time their infections were reported. A high rate of extrapulmonary manifestations (n = 46, 44%) was also reported. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Tuberculosis
KW - Mycobacterial diseases
KW - Chronic granulomatous disease
KW - Prednisone
KW - Methotrexate
KW - Etanercept
KW - Infliximab
N1 - Accession Number: 44922398; Winthrop, Kevin L. 1; Email Address: winthrop@ohsu.edu; Chang, Eric 1; Yamashita, Shellie 1; Iademarco, Michael F. 2; LoBue, Philip A. 3; Affiliations: 1: Oregon Health and Sciences University, Portland, Oregon, USA; 2: US Public Health Service, Washington, DC, USA; 3: Centers for Disease Control and Prevention, Atlanta, Georgia, USA; Issue Info: Oct2009, Vol. 15 Issue 10, p1556; Thesaurus Term: Tuberculosis; Subject Term: Mycobacterial diseases; Subject Term: Chronic granulomatous disease; Subject Term: Prednisone; Subject Term: Methotrexate; Subject Term: Etanercept; Subject Term: Infliximab; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Billinger, Megan E.
AU - Olivier, Kenneth N.
AU - Viboud, Cecile
AU - De Oca, Ruben Montes
AU - Steiner, Claudia
AU - Holland, Steven M.
AU - Prevots, D. Rebecca
T1 - Nontuberculous Mycobacteria-associated Lung Disease in Hospitalized Persons, United States, 1998-2005.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/10//
VL - 15
IS - 10
M3 - Article
SP - 1562
EP - 1569
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - The prevalence and trends of pulmonary nontuberculous mycobacteria (NTM)--associated hospitalizations in the United States were estimated using national hospital discharge data. Records were extracted for all persons with a pulmonary NTM International Classification of Diseases code (031.0) hospitalized in the 11 states with continuous data available from 1998 through 2005. Prevalence was calculated using US census data. Pulmonary NTM hospitalizations (031.0) increased significantly with age among both sexes: relative prevalence for persons 70-79 years of age compared with those 40-49 years of age was 15/100,000 for women (9.4 vs. 0.6) and 9/100,000 for men (7.6 vs. 0.83). Annual prevalence increased significantly among men and women in Florida (3.2%/year and 6.5%/year, respectively) and among women in New York (4.6%/year) with no significant changes in California. The prevalence of pulmonary NTM-associated hospitalizations is increasing in selected geographic areas of the United States. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Mycobacteria
KW - Lung diseases
KW - Hospital care
KW - Hospitals -- Admission & discharge
KW - Medical care -- United States
KW - United States
N1 - Accession Number: 44922399; Billinger, Megan E. 1; Olivier, Kenneth N. 2; Viboud, Cecile 2; De Oca, Ruben Montes 2; Steiner, Claudia 3; Holland, Steven M. 2; Prevots, D. Rebecca 2; Email Address: rprevots@niaid.nih.gov; Affiliations: 1: George Washington University, Washington, DC, USA; 2: National Institutes of Health, Bethesda, Maryland, USA; 3: Agency for Healthcare Research and Quality, Rockville, Maryland, USA; Issue Info: Oct2009, Vol. 15 Issue 10, p1562; Thesaurus Term: Mycobacteria; Subject Term: Lung diseases; Subject Term: Hospital care; Subject Term: Hospitals -- Admission & discharge; Subject Term: Medical care -- United States; Subject: United States; Number of Pages: 8p; Illustrations: 3 Charts, 7 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Planitzer, Christina B.
AU - Modrof, Jens
AU - Yu, Mei-ying W.
AU - Kreil, Thomas R.
T1 - West Nile Virus Infection in Plasma of Blood and Plasma Donors, United States.
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
Y1 - 2009/10//
VL - 15
IS - 10
M3 - Article
SP - 1668
EP - 1670
PB - Centers for Disease Control & Prevention (CDC)
SN - 10806040
AB - This study investigated the association of ongoing West Nile virus (WNV) infections with neutralizing antibody titers in US plasma-derived intravenous immune globulin released during 2003-2008. Titers correlated closely with the prevalence of past WNV infection in blood donors, with 2008 lots indicating a prevalence of 1%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - West Nile fever
KW - West Nile virus
KW - Globulins
KW - Immunoglobulins
KW - Flaviviral diseases
KW - Blood donors
N1 - Accession Number: 44922424; Planitzer, Christina B. 1; Modrof, Jens 1; Yu, Mei-ying W. 2; Kreil, Thomas R. 1; Email Address: thomas_kreil@baxter.com; Affiliations: 1: Baxter Bioscience, Vienna, Austria; 2: US Food and Drug Administration, Bethesda, Maryland, USA; Issue Info: Oct2009, Vol. 15 Issue 10, p1668; Thesaurus Term: West Nile fever; Thesaurus Term: West Nile virus; Thesaurus Term: Globulins; Subject Term: Immunoglobulins; Subject Term: Flaviviral diseases; Subject Term: Blood donors; Number of Pages: 3p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.3201/eid1510.080711
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44922424&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105234398
T1 - Nontuberculous mycobacteria infections and anti-tumor necrosis factor-alpha therapy.
AU - Winthrop KL
AU - Chang E
AU - Yamashita S
AU - Iademarco MF
AU - Lobue PA
AU - Winthrop, Kevin L
AU - Chang, Eric
AU - Yamashita, Shellie
AU - Iademarco, Michael F
AU - LoBue, Philip A
Y1 - 2009/10//
N1 - Accession Number: 105234398. Language: English. Entry Date: 20100205. Revision Date: 20161116. Publication Type: journal article; research; review. Journal Subset: Biomedical; USA. Grant Information: K08 HS017552/HS/AHRQ HHS/United States. NLM UID: 9508155.
KW - Immunosuppressive Agents -- Pharmacodynamics
KW - Mycobacterium
KW - Mycobacterium Infections -- Etiology
KW - Mycobacterium Infections -- Microbiology
KW - Tumor Necrosis Factor -- Antagonists and Inhibitors
SP - 1556
EP - 1561
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
JA - EMERGING INFECT DIS
VL - 15
IS - 10
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - Patients receiving anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapy are at increased risk for tuberculosis and other granulomatous diseases, but little is known about illness caused by nontuberculous mycobacteria (NTM) in this setting. We reviewed the US Food and Drug Administration MedWatch database for reports of NTM disease in patients receiving anti-TNF-alpha therapy. Of 239 reports collected, 105 (44%) met NTM disease criteria. Median age was 62 years; the majority of patients (66, 65%) were female, and most (73, 70%) had rheumatoid arthritis. NTM infections were associated with infliximab (n = 73), etanercept (n = 25), and adalimumab (n = 7); most patients were taking prednisone (n = 68, 65%) or methotrexate (n = 58, 55%) concurrently. Mycobacteria avium (n = 52, 50%) was most commonly implicated, and 9 patients (9%) had died at the time their infections were reported. A high rate of extrapulmonary manifestations (n = 46, 44%) was also reported.
SN - 1080-6040
AD - Departments of Infectious Diseases, Ophthalmology, and Public Health and Preventive Medicine, Oregon Health and Sciences University, Portland, Oregon 97239, USA
AD - Oregon Health and Sciences University, Portland, Oregon, USA (K.L. Winthrop, E. Chang, S. Yamashita); US Public Health Service, Washington, DC, USA (M.F. Iademarco); and Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.A. LoBue).
U2 - PMID: 19861045.
DO - 10.3201/eid1510.090310
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105234398&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105234399
T1 - Nontuberculous mycobacteria-associated lung disease in hospitalized persons, United States, 1998-2005.
AU - Billinger ME
AU - Olivier KN
AU - Viboud C
AU - de Oca RM
AU - Steiner C
AU - Holland SM
AU - Prevots DR
AU - Billinger, Megan E
AU - Olivier, Kenneth N
AU - Viboud, Cecile
AU - de Oca, Ruben Montes
AU - Steiner, Claudia
AU - Holland, Steven M
AU - Prevots, D Rebecca
Y1 - 2009/10//
N1 - Accession Number: 105234399. Language: English. Entry Date: 20100205. Revision Date: 20161116. Publication Type: journal article. Journal Subset: Biomedical; USA. Grant Information: //Intramural NIH HHS/United States. NLM UID: 9508155.
KW - Mycobacterium Infections -- Epidemiology
KW - Mycobacterium Infections -- Microbiology
KW - Adolescence
KW - Adult
KW - Demography
KW - Aged
KW - Aged, 80 and Over
KW - Child
KW - Child, Preschool
KW - Female
KW - Infant
KW - Infant, Newborn
KW - Inpatients
KW - Lung Diseases -- Epidemiology
KW - Lung Diseases -- Microbiology
KW - Male
KW - Middle Age
KW - Prevalence
KW - United States
KW - Young Adult
SP - 1562
EP - 1569
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
JA - EMERGING INFECT DIS
VL - 15
IS - 10
CY - Atlanta, Georgia
PB - Centers for Disease Control & Prevention (CDC)
AB - The prevalence and trends of pulmonary nontuberculous mycobacteria (NTM)-associated hospitalizations in the United States were estimated using national hospital discharge data. Records were extracted for all persons with a pulmonary NTM International Classification of Diseases code (031.0) hospitalized in the 11 states with continuous data available from 1998 through 2005. Prevalence was calculated using US census data. Pulmonary NTM hospitalizations (031.0) increased significantly with age among both sexes: relative prevalence for persons 70-79 years of age compared with those 40-49 years of age was 15/100,000 for women (9.4 vs. 0.6) and 9/100,000 for men (7.6 vs. 0.83). Annual prevalence increased significantly among men and women in Florida (3.2%/year and 6.5%/year, respectively) and among women in New York (4.6%/year) with no significant changes in California. The prevalence of pulmonary NTM-associated hospitalizations is increasing in selected geographic areas of the United States.
SN - 1080-6040
AD - George Washington University, Washington, DC, USA
AD - George Washington University, Washington, DC, USA (M.E. Billinger); National Institutes of Health, Bethesda, Maryland, USA (K.N. Olivier, C. Viboud, R. Montes de Oca, S.M. Holland, D.R. Prevots); and Agency for Healthcare Research and Quality, Rockville, Maryland, USA (C. Steiner).
U2 - PMID: 19861046.
DO - 10.3201/eid1510.090196
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105234399&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
T1 - GENOMIC MEDICINE AND RACIAL/ETHNIC HEALTH DISPARITIES: PROMISES, PERILS, AND THE CHALLENGES FOR HEALTH CARE AND PUBLIC HEALTH POLICY.
AU - Moonesinghe, Ramal
AU - Jones, Walter
AU - Honoré, Peggy A.
AU - Truman, Benedict I.
AU - Graham, Garth
JO - Ethnicity & Disease
JF - Ethnicity & Disease
Y1 - 2009/10//
VL - 19
IS - 4
SP - 473
EP - 478
SN - 1049510X
N1 - Accession Number: 47117793; Author: Moonesinghe, Ramal: 1 Author: Jones, Walter: 2 Author: Honoré, Peggy A.: 3 email: Peggy.Honore@hhs.gov. Author: Truman, Benedict I.: 1 Author: Graham, Garth: 3 ; Author Affiliation: 1 Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Atlanta, Georgia: 2 Medical University of South Carolina, College of Health Professions, South Carolina: 3 Office of Minority Health, Office of Public Health and Science, US Department of Health and Human Services, Rockville, Maryland; No. of Pages: 6; Language: English; Publication Type: Article; Update Code: 20091227
N2 - Scientific and policy debates following new genetic discoveries have been intense and emotional when they have involved questions about the causes of, and solutions for, racial and ethnic health disparities in the United States. The difference in prevalence of diseases, allele frequency and genotype frequency among racial/ethnic groups are well known. The genomic profile for a given disease could have different genetic variants for different racial/ethnic groups. Do these results indicate that we have to consider different genetic tests and different genomic medicine for different racial/ethnic groups? If we do this, what is the impact on ethnic and class disparities in health care services in the United States? Current advances in genetic medicine are very promising; however, we must consider the possible impacts of these findings on health disparities, and how genetic medicine can be extended to everyone, not just those who can pay the often high price. If genomic medicine is to be a valid and reliable technology for all citizens regardless of wealth, race, ethnicity, or other determinants of social disadvantage, public health policymakers have to consider a number of policy issues and implications. ABSTRACT FROM AUTHOR
KW - *PUBLIC health
KW - HEALTH disparities
KW - MEDICAL policy
KW - HEALTH services administration
KW - GENE frequency
KW - MEDICAL genetics
KW - ETHNICITY
KW - UNITED States
KW - Allele Frequency
KW - Genetic Tests
KW - Genomic Medicine
KW - Healthcare Disparity
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DP - EBSCOhost
DB - s3h
ER -
TY - JOUR
AU - Petrignani, Mariska W. F.
AU - Kroneman, Annelies
AU - Van Hunen, Rianne
AU - Vennema, Harry
AU - Koopmans, Marion
T1 - Too early to stop immigrant vaccination programmes.
JO - European Journal of Public Health
JF - European Journal of Public Health
Y1 - 2009/10//
VL - 19
IS - 5
M3 - Article
SP - 454
EP - 454
SN - 11011262
AB - The article focuses on a nationwide hepatitis A virus (HAV) sequencing conducted on Moroccan and Turkish immigrants in the Netherlands. The preliminary results of the sequencing revealed that 87 strains tested are of Moroccan origin against 4 strains of Turkish origin. The results indicated a clear difference between the risk coming from Turkey and Morocco.
KW - HEPATITIS A virus
KW - ENTEROVIRUSES
KW - HEPATITIS viruses
KW - IMMIGRANTS -- Health
KW - NETHERLANDS
N1 - Accession Number: 45236065; Petrignani, Mariska W. F. 1; Email Address: m.petrignani@ggdzhw.nl Kroneman, Annelies 2 Van Hunen, Rianne 1 Vennema, Harry 2 Koopmans, Marion 2; Affiliation: 1: Department of Infectious Disease Control, Public Health Service, Zoetermeer, The Netherlands 2: Laboratory for Infectious Diseases and Perinatal Screening, Centre for Infectious Disease Control, RIVM Bilthoven, The Netherlands; Source Info: Oct2009, Vol. 19 Issue 5, p454; Subject Term: HEPATITIS A virus; Subject Term: ENTEROVIRUSES; Subject Term: HEPATITIS viruses; Subject Term: IMMIGRANTS -- Health; Subject Term: NETHERLANDS; Number of Pages: 1p; Document Type: Article
L3 - 10.1093/eurpub/ckp101
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105226666
T1 - Too early to stop immigrant vaccination programmes.
AU - Petrignani MW
AU - Kroneman A
AU - van Hunen R
AU - Vennema H
AU - Koopmans M
Y1 - 2009/10//
N1 - Accession Number: 105226666. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; commentary. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 9204966.
KW - Hepatitis A Vaccines -- Administration and Dosage
KW - Immigrants
KW - Immunization Programs -- Administration
KW - Child
KW - Netherlands
SP - 454
EP - 454
JO - European Journal of Public Health
JF - European Journal of Public Health
JA - EUR J PUBLIC HEALTH
VL - 19
IS - 5
PB - Oxford University Press / USA
SN - 1101-1262
AD - Department of Infectious Disease Control, Public Health Service, Zoetermeer, The Netherlands
U2 - PMID: 19587228.
DO - eurpub/ckp101
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105226668
T1 - Diabetes prevalence and risk factors among ethnic minorities.
AU - Ujcic-Voortman JK
AU - Schram MT
AU - Jacobs-van der Bruggen MA
AU - Verhoeff AP
AU - Baan CA
Y1 - 2009/10//
N1 - Accession Number: 105226668. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 9204966.
KW - Diabetes Mellitus -- Ethnology
KW - Immigrants -- Statistics and Numerical Data
KW - Adolescence
KW - Adult
KW - Age Factors
KW - Aged
KW - Female
KW - Health Behavior -- Ethnology
KW - Human
KW - Life Style
KW - Male
KW - Middle Age
KW - Morocco -- Ethnology
KW - Netherlands
KW - Obesity -- Ethnology
KW - Prevalence
KW - Risk Factors
KW - Socioeconomic Factors
KW - Surveys
KW - Turkey -- Ethnology
KW - Young Adult
SP - 511
EP - 515
JO - European Journal of Public Health
JF - European Journal of Public Health
JA - EUR J PUBLIC HEALTH
VL - 19
IS - 5
PB - Oxford University Press / USA
AB - BACKGROUND: Ethnic minorities living in Western societies may have a higher prevalence of diabetes. We investigated whether the prevalence of diabetes among Turkish and Moroccan migrants differs from the indigenous urban population in the Netherlands, and whether these differences can be explained by differences in risk factors. METHODS: In 2004 a general health survey, stratified by ethnicity and age, was carried out among the population of Amsterdam. The current study included 375 Turkish, 314 Moroccan and 417 Dutch individuals aged 18-70 years. Participants underwent a physical examination and a health interview. Diabetes was based on self-report, the use of anti-diabetic medicine, blood glucose levels and HbA1c. RESULTS: The prevalence of diabetes in the Amsterdam population was significantly higher in Turkish (5.6%) and Moroccan (8.0%), compared to Dutch individuals (3.1%). These differences, which were much larger after adjustment for age, were only partly explained by the lower socioeconomic status and higher frequency of obesity among ethnic minorities. The difference between Dutch and Moroccan individuals remained significant even after adjustments for multiple risk factors. The typical age of onset of diabetes in both Turks and Moroccans is respectively one and two decades younger than in the indigenous population. CONCLUSION: Diabetes is more prevalent among Turkish and Moroccan migrants as compared to the indigenous population. Only part of this difference can be explained by differences in demographic and lifestyle risk factors.
SN - 1101-1262
AD - Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, the Netherlands
U2 - PMID: 19587231.
DO - eurpub/ckp096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105226668&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Iha, M. H.
AU - Trucksess, M. W.
AU - Tournas, V. H.
T1 - Effect of processing on ochratoxin A content in dried beans.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2009/10//
VL - 26
IS - 10
M3 - Article
SP - 1389
EP - 1395
PB - Taylor & Francis Ltd
SN - 19440049
AB - Dried pink beans naturally contaminated with ochratoxin A (OTA) and dried carioca beans artificially contaminated with OTA by inoculation with Aspergillus ochraceus (ATCC 22947) were tested for ochratoxin A levels as follows: dried beans were washed with water for 2, 60 or 120 min, soaked in water for 60, 120 min or 10 h, and cooked for 60 or 120 min. At each step, test water and beans were separated. Test water, raw beans and cooked beans were analyzed for OTA. The amount of OTA partitioned into water and in residual beans was determined by methanol-sodium bicarbonate extraction, buffer dilution, immunoaffinity column cleanup, liquid chromatographic separation and fluorescence detection. The results demonstrated that the distribution of OTA in processing water and beans depends on the method of preparation. All treatments (washing, soaking and cooking) when applied individually reduced the amounts of OTA retained in bean flour and whole beans. Higher amounts of OTA remained in whole beans than in bean flour after removing the processing water. The combination of the three treatments eliminated about 50% of the toxin from whole beans. This study provides evidence that discarding the washing, soaking and cooking water leads to a significant reduction in OTA contamination in dried beans. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Vegetables -- Contamination
KW - Extraction (Chemistry)
KW - Toxins
KW - Beans
KW - Ochratoxins
KW - beans
KW - immunoaffinity columns
KW - mycotoxins
KW - ochratoxin A
KW - processing HPLC
N1 - Accession Number: 47522146; Iha, M. H. 1; Email Address: mhiha@ial.sp.gov.br; Trucksess, M. W. 2; Tournas, V. H. 2; Affiliations: 1: Instituto Adolfo Lutz, Laboratorio I de Ribeirao Preto, 14085-410 Brazil.; 2: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA.; Issue Info: Oct2009, Vol. 26 Issue 10, p1389; Thesaurus Term: Vegetables -- Contamination; Thesaurus Term: Extraction (Chemistry); Thesaurus Term: Toxins; Thesaurus Term: Beans; Subject Term: Ochratoxins; Author-Supplied Keyword: beans; Author-Supplied Keyword: immunoaffinity columns; Author-Supplied Keyword: mycotoxins; Author-Supplied Keyword: ochratoxin A; Author-Supplied Keyword: processing HPLC; NAICS/Industry Codes: 111130 Dry Pea and Bean Farming; NAICS/Industry Codes: 111219 Other Vegetable (except Potato) and Melon Farming; NAICS/Industry Codes: 111419 Other Food Crops Grown Under Cover; NAICS/Industry Codes: 115114 Postharvest Crop Activities (except Cotton Ginning); NAICS/Industry Codes: 411120 Oilseed and grain merchant wholesalers; Number of Pages: 7p; Illustrations: 2 Diagrams, 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/02652030903013286
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Whittaker, Paul
T1 - Comparison of Yersinia pestis to other closely related Yersinia species using fatty acid profiles
JO - Food Chemistry
JF - Food Chemistry
Y1 - 2009/10//
VL - 116
IS - 3
M3 - Article
SP - 629
EP - 632
SN - 03088146
AB - Abstract: Capillary gas chromatography with flame ionisation detection (GC–FID) was used to determine the cellular fatty acid (CFA) profiles of six Yersinia pestis strains. The profiles were then compared with the CFA profiles of other closely related Yersinia species including: Y. pseudotuberculosis, Y. enterocolitica, Y. intermedii, Y. kristensenii and Y. frederiksenii. For GC–FID analysis, whole cell fatty acid methyl esters (FAMEs) from cells cultured on brain–heart infusion (BHI) agar at 35 °C for 24h were obtained by saponification, methylation and extraction into hexane/methyl tert-butyl ether. A data set for each Yersinia species was prepared using fatty acid profiles from five replicates prepared on different days. Major fatty acids of the 26 Yersinia strains evaluated in this study were straight-chain 12:0, 14:0, 15:0, 16:0 and unsaturated summed 16:1 ω7c/16:1 ω6c, 18:1 ω7c, and summed 14:0 3OH/16:1 iso, and 17:0 ω cyclo 7–8. The CFA profiles for Y. pestis and Y. pseudotuberculosis are similar, but there are several fatty acids, 16:1 ω5c, 16:0, 17:1 ω7c, 17:0 ω cyclo 7–8, 19:0 and summed 18:2 ω6c, 9c/18:0 ante, that differ significantly between these two species. Analysis of FAMEs from Yersinia strains grown on BHI agar by a rapid GC–FID method can provide a sensitive procedure for the identification of these organisms, and this analytical method provides a procedure for the differentiation of Y. pestis strains from closely related Yersinia species. [Copyright &y& Elsevier]
AB - Copyright of Food Chemistry is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - YERSINIA pestis
KW - FATTY acids
KW - GAS chromatography
KW - BACTERIAL cultures
KW - IDENTIFICATION of bacteria
KW - BACTERIAL diversity
KW - YERSINIA pseudotuberculosis
KW - YERSINIA enterocolitica
KW - Fatty acids
KW - Gas chromatography
KW - Yersinia pestis
KW - Yersinia species
N1 - Accession Number: 40117445; Whittaker, Paul 1; Email Address: paul.whittaker@fda.hhs.gov; Affiliation: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, United States; Source Info: Oct2009, Vol. 116 Issue 3, p629; Subject Term: YERSINIA pestis; Subject Term: FATTY acids; Subject Term: GAS chromatography; Subject Term: BACTERIAL cultures; Subject Term: IDENTIFICATION of bacteria; Subject Term: BACTERIAL diversity; Subject Term: YERSINIA pseudotuberculosis; Subject Term: YERSINIA enterocolitica; Author-Supplied Keyword: Fatty acids; Author-Supplied Keyword: Gas chromatography; Author-Supplied Keyword: Yersinia pestis; Author-Supplied Keyword: Yersinia species; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.foodchem.2009.02.073
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105425351
T1 - Validating household reports of health care use in the medical expenditure panel survey.
AU - Zuvekas SH
AU - Olin GL
Y1 - 2009/10//
N1 - Accession Number: 105425351. Language: English. Entry Date: 20091009. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Blind Peer Reviewed; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Health Services Administration; Peer Reviewed; USA. NLM UID: 0053006.
KW - Data Collection Methods
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Services -- Economics
KW - Health Services -- Utilization
KW - Insurance -- Statistics and Numerical Data
KW - Interviews
KW - Aged
KW - Aged, 80 and Over
KW - Cognition
KW - Emergency Service -- Economics
KW - Emergency Service -- Statistics and Numerical Data
KW - Female
KW - Health Status
KW - Male
KW - Medicare -- Statistics and Numerical Data
KW - Office Visits -- Economics
KW - Office Visits -- Statistics and Numerical Data
KW - Patient Admission -- Economics
KW - Patient Admission -- Statistics and Numerical Data
KW - Reproducibility of Results
KW - Socioeconomic Factors
KW - United States
KW - Human
SP - 1679
EP - 1700
JO - Health Services Research
JF - Health Services Research
JA - HEALTH SERV RES
VL - 44
IS - 5p1
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0017-9124
AD - Center for Financing, Access, and Cost Trends (CFACT), Agency for Healthcare Research and Quality (AHRQ), Rockville, MD 20850.
U2 - PMID: 19619249.
DO - 10.1111/j.1475-6773.2009.00995.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Suzuki, Kaoru
AU - Koizumi, Shinji
T1 - An Improved Transfection Assay for Evaluating the Effects of Heavy Metals.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/10//
VL - 47
IS - 4
M3 - Article
SP - 419
EP - 422
SN - 00198366
AB - The article presents information on the transfection assay which is used to determine the effects of heavy metals present in industrial chemicals on the health of the workers. It mentions that reporter gene is used as an indicator to determine the level of transfected gene expression and a reference gene is used for the comparison.
KW - Assaying
KW - Heavy metals
KW - Chemical industry
KW - Gene transfection
KW - Reporter genes
KW - Gene expression
KW - Cadmium
KW - Health effects
KW - Heavy metal
KW - Human cells
KW - Transfection assay
KW - Zinc
N1 - Accession Number: 77416737; Suzuki, Kaoru 1; Koizumi, Shinji 1; Affiliations: 1: Human Engineering and Risk Management Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2009, Vol. 47 Issue 4, p419; Thesaurus Term: Assaying; Thesaurus Term: Heavy metals; Thesaurus Term: Chemical industry; Subject Term: Gene transfection; Subject Term: Reporter genes; Subject Term: Gene expression; Author-Supplied Keyword: Cadmium; Author-Supplied Keyword: Health effects; Author-Supplied Keyword: Heavy metal; Author-Supplied Keyword: Human cells; Author-Supplied Keyword: Transfection assay; Author-Supplied Keyword: Zinc; NAICS/Industry Codes: 325194 Cyclic Crude, Intermediate, and Gum and Wood Chemical Manufacturing; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 418410 Chemical (except agricultural) and allied product merchant wholesalers; NAICS/Industry Codes: 424690 Other Chemical and Allied Products Merchant Wholesalers; Number of Pages: 4p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - McKinney, Walter
AU - Chen, Bean
AU - Frazer, Dave
T1 - Computer controlled multi-walled carbon nanotube inhalation exposure system.
JO - Inhalation Toxicology
JF - Inhalation Toxicology
Y1 - 2009/10//
VL - 21
IS - 12
M3 - Article
SP - 1053
EP - 1061
SN - 08958378
AB - Inhalation exposure systems are necessary tools for determining the dose–response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi-walled carbon nanotubes (MWCNT). An aerosol generator was developed which was capable of suspending a respirable fraction of multi-walled carbon nanotubes from bulk material. The output of the generator was used to expose small laboratory animals to constant aerosol concentrations up to 12 mg/m3. Particle distribution and morphology of the MWCNT aerosol delivered to the exposure chamber were measured and compared to samples previously taken from air inside a facility that produces MWCNT. The comparison showed the MWCNT generator was producing particles similar in size and shape to those found in a work environment. The inhalation exposure system combined air flow controllers, particle monitors, data acquisition devices, and custom software with automatic feedback control to achieve constant and repeatable exposure chamber temperature, relative humidity, pressure, aerosol concentration, and particle size distribution. The automatic control algorithm was capable of maintaining the mean aerosol concentration to within 0.1 mg/m3 of the selected target value, and it could reach 95% of the target value in less than 10 minutes during the start-up of an inhalation exposure. One of the major advantages of this system was that once the exposure parameters were selected, a minimum amount of operator intervention was required over the exposure period. [ABSTRACT FROM AUTHOR]
AB - Copyright of Inhalation Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Aerosols (Sprays)
KW - Poisonous gases -- Toxicology
KW - Laboratory animals
KW - Carbon nanotubes
KW - Nanotubes
KW - Carbon nanotube
KW - computer control
KW - exposure system
KW - feedback control
KW - inhalation exposure
KW - particle distribution
KW - particle generation
N1 - Accession Number: 44285044; McKinney, Walter 1; Email Address: wdm9@cdc.gov; Chen, Bean 1; Frazer, Dave 1; Affiliations: 1: Centers for Disease Control and Prevention/The National Institute for Occupational Safety and Health (CDC/NIOSH), Morgantown, WV, USA.; Issue Info: Oct2009, Vol. 21 Issue 12, p1053; Thesaurus Term: Aerosols (Sprays); Thesaurus Term: Poisonous gases -- Toxicology; Subject Term: Laboratory animals; Subject Term: Carbon nanotubes; Subject Term: Nanotubes; Author-Supplied Keyword: Carbon nanotube; Author-Supplied Keyword: computer control; Author-Supplied Keyword: exposure system; Author-Supplied Keyword: feedback control; Author-Supplied Keyword: inhalation exposure; Author-Supplied Keyword: particle distribution; Author-Supplied Keyword: particle generation; NAICS/Industry Codes: 112999 All other miscellaneous animal production; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Illustrations: 1 Black and White Photograph, 4 Diagrams, 9 Graphs; Document Type: Article
L3 - 10.1080/08958370802712713
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Pierik, Frank H.
AU - Deddens, James A.
AU - Burdorf, Alex
AU - Keizer-Schrama, Sabine M. P. F. de Muinck
AU - Jong, Frank H. de
AU - Weber, Rob F. A.
T1 - The hypothalamus-pituitary-testis axis in boys during the first six months of life: a comparison of cryptorchidism and hypospadias cases with controls.
JO - International Journal of Andrology
JF - International Journal of Andrology
Y1 - 2009/10//
VL - 32
IS - 5
M3 - Article
SP - 453
EP - 461
PB - Wiley-Blackwell
SN - 01056263
AB - It is inconclusive whether the feedback mechanisms of the hypothalamus-pituitary-testis (HTP) axis are already established in the first 6 months of life, partly due to the dramatic changes in HPT-axis hormone levels over this period. Moreover, it is unclear whether these hormone levels are aberrant in boys with cryptorchidism or hypospadias, and therefore predictive for future fertility. We studied the regulation mechanisms of the HTP axis, and the effect of age, in boys 1–6 months of age. Secondly, we studied testicular function - as reflected by HPT hormones - in newborns with cryptorchidism or hypospadias. Sera from a population sample of infants with cryptorchidism ( n = 43), hypospadias ( n = 41) and controls ( n = 113) were analyzed for inhibin B, anti-Müllerian hormone (AMH), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin (SHBG). LH, testosterone, non-shbg-bound testosterone (NSBT), and AHM levels showed significant age-related trends. After age-correction, a negative correlation between FSH and inhibin B was observed ( r = −0.43). The only significant group-differences were lower testosterone and NSBT levels in cryptorchidism cases, with a mean testosterone of 1.8 and 2.6 nmol/L and a mean NSBT of 0.48 and 0.70 nmol/L for cryptorchidism cases and controls, respectively. The higher levels of LH, testosterone, and NSBT in boys born pre-term or with a low birthweight indicate that abnormal prenatal development may determine postnatal testis function. Our results support the hypothesis that the inhibin B – FSH feedback loop is already functional before puberty. The lower testosterone and NSBT levels indicate that disturbed Leydig cell function can already be detected early after birth in cryptorchid boys. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Andrology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPOTHALAMUS
KW - CRYPTORCHISM
KW - HYPOSPADIAS
KW - FERTILITY
KW - LUTEINIZING hormone
KW - AHM
KW - cryptorchidism
KW - FSH
KW - hypospadias
KW - inhibin B
KW - LH
KW - newborn boys
KW - testosterone
N1 - Accession Number: 44076758; Pierik, Frank H.; Email Address: frank.pierik@tno.nl Deddens, James A. 1 Burdorf, Alex 2 Keizer-Schrama, Sabine M. P. F. de Muinck 3 Jong, Frank H. de 4 Weber, Rob F. A. 5; Affiliation: 1: National Institute for Occupational Safety and Health, Cincinnati, OH, USA 2: Department of Public Health, Erasmus MC, Rotterdam, The Netherlands 3: Department of Pediatric Endocrinology, Erasmus MC 4: Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands 5: Department of Andrology, Erasmus MC; Source Info: Oct2009, Vol. 32 Issue 5, p453; Subject Term: HYPOTHALAMUS; Subject Term: CRYPTORCHISM; Subject Term: HYPOSPADIAS; Subject Term: FERTILITY; Subject Term: LUTEINIZING hormone; Author-Supplied Keyword: AHM; Author-Supplied Keyword: cryptorchidism; Author-Supplied Keyword: FSH; Author-Supplied Keyword: hypospadias; Author-Supplied Keyword: inhibin B; Author-Supplied Keyword: LH; Author-Supplied Keyword: newborn boys; Author-Supplied Keyword: testosterone; Number of Pages: 9p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2605.2008.00877.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44076758&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fontana Zocoli, Angela Maria
AU - Catalani Morata, Thais
AU - Mendes Marques, Jair
AU - Corteletti, Lilian Jacob
T1 - Brazilian young adults and noise: Attitudes, habits, and audiological characteristics.
JO - International Journal of Audiology
JF - International Journal of Audiology
Y1 - 2009/10//
VL - 48
IS - 10
M3 - Article
SP - 692
EP - 699
SN - 14992027
AB - The objective of this study was to examine behaviors and attitudes of Brazilian teenagers towards noise, and determine their audiological characteristics. Participants were 245 young persons (14 to 18 years old) who attended private school. Behaviors and attitudes were measured using the validated Portuguese version of the Youth Attitude to Noise Scale (YANS). Pure-tone audiometry was used to evaluate the hearing of a sub-sample of 24 participants. Music played through personal media players was the most common exposure reported. A substantial percentage of participants reported temporary tinnitus (69%) after attending discos, music concerts, and listening to music through headphones. Tinnitus complaints were more frequent among females (41%) than males (27%). Four participants (1.6%) reported use of a hearing protector. Among a subsample of 24 participants, two (8%) young women had bilateral audiometric notches. YANS scores in the present study were slightly lower than those obtained in Sweden and the US, indicating a more negative attitude towards noise. Gender, age, country, and/or region are variables that will influence exposure to noise or music and possibly hearing outcomes. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Audiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TEENAGERS -- Health
KW - HUMAN behavior
KW - HEARING aids
KW - NOISE -- Psychological aspects
KW - TINNITUS
KW - Demographics/epidemiology
KW - Hearing conservation
KW - Psycho-social/emotional
KW - Tinnitus
N1 - Accession Number: 44398623; Fontana Zocoli, Angela Maria 1 Catalani Morata, Thais 1,2 Mendes Marques, Jair 1 Corteletti, Lilian Jacob 1; Affiliation: 1: Graduate Program in Communication Disorders, Universidade Tuiuti do Paraná, Brazil 2: Hearing Loss Prevention Team, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, USA; Source Info: Oct2009, Vol. 48 Issue 10, p692; Subject Term: TEENAGERS -- Health; Subject Term: HUMAN behavior; Subject Term: HEARING aids; Subject Term: NOISE -- Psychological aspects; Subject Term: TINNITUS; Author-Supplied Keyword: Demographics/epidemiology; Author-Supplied Keyword: Hearing conservation; Author-Supplied Keyword: Psycho-social/emotional; Author-Supplied Keyword: Tinnitus; NAICS/Industry Codes: 446199 All Other Health and Personal Care Stores; NAICS/Industry Codes: 423450 Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 8p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/14992020902971331
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - HARRISON, JOEL C.
AU - HAM, JASON E.
T1 - β-Ionone reactions with the nitrate radical: Rate constant and gas-phase products.
JO - International Journal of Chemical Kinetics
JF - International Journal of Chemical Kinetics
Y1 - 2009/10//
VL - 41
IS - 10
M3 - Article
SP - 629
EP - 641
SN - 05388066
AB - The bimolecular rate constant of kNO3⋅+β-ionone (9.4 ± 2.4 × 10-12 cm3 molecule-1 s-1 was measured using the relative rate technique for the reaction of the nitrate radical (NO3•) with 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one (β-ionone) at (297 ± 3) K and 1 atmosphere total pressure. In addition, the products of β-ionone + NO3• reaction were also investigated. The identified reaction products were glyoxal (HC(&dbond;O)C(&dbond;O)H), and methylglyoxal (CH3C(&dbond;O)C(&dbond;O)H). Derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine and N,O-bis(trimethylsilyl)trifluoroacetamide were used to propose the other major reaction products: 3-oxobutane-1,2-diyl nitrate, 2,6,6-trimethylcyclohex-1-ene-carbaldehyde, 2-oxo-1-(2,6,6-trimethylcyclohex-1-en-1-yl)ethyl nitrate, pentane-2,4-dione, 3-oxo-1-(2,6,6-trimethylcyclohex-1-en-1-yl)butane-1,2-diyl dinitrate, 3,3-dimethylcyclohexane-1,2-dione, and 4-oxopent-2-enal. The elucidation of these products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible β-ionone + NO3• reaction mechanisms based on previously published volatile organic compound + NO3• gas-phase mechanisms. The additional gas-phase products 5-acetyl-2-ethylidene-3-methylcyclopentyl nitrate, 1-(1-hydroxy-7,7-dimethyl-2,3,4,5,6,7-hexahydro-1 H-inden-2-yl)ethanone, 1-(1-hydroxy-3a,7-dimethyl-2,3,3a,4,5,6,-hexahydro-1 H-inden-2-yl)ethanone, and 5-acetyl-2-ethylidene-3-methylcyclopentanone are proposed to be the result of cyclization through a reaction intermediate. © 2009 Wiley Periodicals, Inc.* This article is a U.S. Government work and, as such, is in the public domain of the United States of America. Int J Chem Kinet 41: 629–641, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of International Journal of Chemical Kinetics is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IONONES
KW - CHEMICAL reactions
KW - NITRATES
KW - NITROGEN compounds
KW - GLYOXAL
N1 - Accession Number: 43832460; HARRISON, JOEL C. 1 HAM, JASON E. 1; Email Address: bvo2@cdc.gov; Affiliation: 1: Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505; Source Info: Oct2009, Vol. 41 Issue 10, p629; Subject Term: IONONES; Subject Term: CHEMICAL reactions; Subject Term: NITRATES; Subject Term: NITROGEN compounds; Subject Term: GLYOXAL; NAICS/Industry Codes: 325199 All Other Basic Organic Chemical Manufacturing; NAICS/Industry Codes: 325190 Other basic organic chemical manufacturing; Number of Pages: 13p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1002/kin.20438
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cornfield, Jerome
AU - Haenszel, William
AU - Hammond, E. Cuyler
AU - Lilienfeld, Abraham M.
AU - Shimkin, Michael B.
AU - Wynder, Ernst L.
T1 - Smoking and lung cancer: recent evidence and a discussion of some questions. 1959.
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Y1 - 2009/10//
VL - 38
IS - 5
M3 - journal article
SP - 1175
EP - 1191
SN - 03005771
AB - Summary This report reviews some of the more recent epidemiologic and experimental findings on the relationship of tobacco smoking to lung cancer, and discusses some criticisms directed against the conclusion that tobacco smoking, especially cigarettes, has a causal role in the increase in broncho-genic carcinoma. The magnitude of the excess lung-cancer risk among cigarette smokers is so great that the results can not be interpreted as arising from an indirect association of cigarette smoking with some other agent or characteristic, since this hypothetical agent would have to be at least as strongly associated with lung cancer as cigarette use; no such agent has been found or suggested. The consistency of all the epidemiologic and experimental evidence also supports the conclusion of a causal relationship with cigarette smoking, while there are serious inconsistencies in reconciling the evidence with other hypotheses which have been advanced. Unquestionably there are areas where more research is necessary, and, of course, no single cause accounts for all lung cancer. The information already available, however, is sufficient for planning and activating public health measures. – J. Nat. Cancer Inst. 22:173–203, 1959. [ABSTRACT FROM PUBLISHER]
AB - Copyright of International Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOBACCO use
KW - SMOKING
KW - LUNGS -- Cancer
KW - TOBACCO -- Physiological effect
KW - EPIDEMIOLOGY
N1 - Accession Number: 45230189; Cornfield, Jerome 1 Haenszel, William 2 Hammond, E. Cuyler 3 Lilienfeld, Abraham M. 4 Shimkin, Michael B. 5 Wynder, Ernst L. 6; Affiliation: 1: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md. Department of Biostatistics, paper #323 2: National Cancer Institute, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 3: American Cancer Society, Inc., New York, N.Y. 4: School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md 5: National Cancer Institute, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md 6: Sloan-Kettering Institute for Cancer Research, New York, N.Y.; Source Info: Oct2009, Vol. 38 Issue 5, p1175; Subject Term: TOBACCO use; Subject Term: SMOKING; Subject Term: LUNGS -- Cancer; Subject Term: TOBACCO -- Physiological effect; Subject Term: EPIDEMIOLOGY; Number of Pages: 17p; Illustrations: 1 Graph; Document Type: journal article
L3 - 10.1093/ije/dyp289
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Özgen Karacan, C.
AU - Goodman, Gerrit
T1 - Hydraulic conductivity changes and influencing factors in longwall overburden determined by slug tests in gob gas ventholes
JO - International Journal of Rock Mechanics & Mining Sciences
JF - International Journal of Rock Mechanics & Mining Sciences
Y1 - 2009/10//
VL - 46
IS - 7
M3 - Article
SP - 1162
EP - 1174
SN - 13651609
AB - Abstract: This study presents the results of core-log analyses from the exploration boreholes, the analyses of face advance rates, and the results of downhole monitoring studies performed in gob gas ventholes for calculation of changes in hydraulic properties in the longwall overburden at a mine site in southwestern (SW) Pennsylvania section of Northern Appalachian Basin. In the first part of the study, coal measure rocks in overburden strata were analyzed and the locations where possible fractures and bedding plane separations would occur were evaluated. In the second part, the hydraulic conductivities were computed by two different slug test analyses methods using the water level changes measured in gob gas ventholes as longwall face approached. Hydraulic conductivities were analyzed with respect to the changes in overburden depth, the locations of the borehole, and mine face advance rates. These data were used to interpret the potential productivities of the gob gas ventholes as a result of fracturing and changes in hydraulic conductivities. The general results showed that the probability of fracturing and bedding plane separations in the overburden increase between strong and weak rock interfaces. Also, the probability of bedding plane separations increases as the interface is close to the extracted coal seam. Evaluation of slug tests showed that the hydraulic conductivity developments in the boreholes and their potential production performances are affected by the underground strata and the roof materials. In situations where the roof material is stiff and thick, the development of high permeability fractures around the borehole will be less. Results also indicated that borehole location with respect to face position affects the fracturing time and permeability evolution as well. Greater overburden depths generally cause earlier fracturing as longwall face approaches, but eventually result in lower hydraulic conductivities and potentially less effective boreholes. Increasing mining rates also resulted in generally lower hydraulic conductivities in the overburden. The results of this study were intended to improve the interpretation of gob gas venthole performance and to provide better siting of these boreholes. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Rock Mechanics & Mining Sciences is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BOREHOLE mining
KW - ROCKS -- Analysis
KW - SOIL permeability
KW - REGOLITH
KW - FRACTURE mechanics
KW - APPALACHIAN Basin
KW - Gob gas ventholes
KW - Hydraulic conductivity
KW - Longwall mining
KW - Methane control
KW - Slug tests
N1 - Accession Number: 44116069; Özgen Karacan, C.; Email Address: cok6@cdc.gov Goodman, Gerrit 1; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, PO Box 18070, Pittsburgh, PA 15236, USA; Source Info: Oct2009, Vol. 46 Issue 7, p1162; Subject Term: BOREHOLE mining; Subject Term: ROCKS -- Analysis; Subject Term: SOIL permeability; Subject Term: REGOLITH; Subject Term: FRACTURE mechanics; Subject Term: APPALACHIAN Basin; Author-Supplied Keyword: Gob gas ventholes; Author-Supplied Keyword: Hydraulic conductivity; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Methane control; Author-Supplied Keyword: Slug tests; Number of Pages: 13p; Document Type: Article
L3 - 10.1016/j.ijrmms.2009.02.005
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shenghui Cui
AU - Jingyun Li
AU - Changqin Hu
AU - Shaohong Jin
AU - Fengqin Li
AU - Yunchang Guo
AU - Lu Ran
AU - Yue Ma
T1 - Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China.
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
Y1 - 2009/10//
VL - 64
IS - 4
M3 - Article
SP - 680
EP - 683
SN - 03057453
AB - Objectives: The objectives of this study were to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in livestock and related workers in four Chinese provinces and the characteristics of these isolates. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RESEARCH
KW - Methicillin-resistant staphylococcus aureus
KW - Competitive exclusion (Microbiology)
KW - Livestock diseases
KW - Provinces
KW - Staphylococcus aureus
KW - China
KW - antimicrobial susceptibility testing
KW - multilocus sequence typing
KW - pulsed field gel electrophoresis
N1 - Accession Number: 44592267; Shenghui Cui 1; Jingyun Li 1; Changqin Hu 1; Shaohong Jin 1; Fengqin Li 2; Yunchang Guo 2; Lu Ran 2; Yue Ma 1; Email Address: nicpbp@263.net; Affiliations: 1: The State Food and Drug Administration, Beijing, People's Republic of China; 2: The Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Issue Info: Oct2009, Vol. 64 Issue 4, p680; Thesaurus Term: RESEARCH; Subject Term: Methicillin-resistant staphylococcus aureus; Subject Term: Competitive exclusion (Microbiology); Subject Term: Livestock diseases; Subject Term: Provinces; Subject Term: Staphylococcus aureus; Subject: China; Author-Supplied Keyword: antimicrobial susceptibility testing; Author-Supplied Keyword: multilocus sequence typing; Author-Supplied Keyword: pulsed field gel electrophoresis; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; Number of Pages: 4p; Illustrations: 2 Charts; Document Type: Article
L3 - 10.1093/jac/dkp275
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105338718
T1 - Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China.
AU - Cui S
AU - Li J
AU - Hu C
AU - Jin S
AU - Li F
AU - Guo Y
AU - Ran L
AU - Ma Y
Y1 - 2009/10//
N1 - Accession Number: 105338718. Language: English. Entry Date: 20091211. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; USA. Special Interest: Oncologic Care. Grant Information: Ministry of Science and Technology of the People's Republic of China and the National Science Foundation. NLM UID: 7513617.
KW - Methicillin Resistance
KW - Microbial Culture and Sensitivity Tests -- China
KW - Staphylococcal Infections -- Epidemiology
KW - Staphylococcus Aureus
KW - Swine
KW - Animal Studies
KW - China
KW - Funding Source
KW - Human
KW - Polymerase Chain Reaction
KW - Prevalence
SP - 680
EP - 683
JO - Journal of Antimicrobial Chemotherapy (JAC)
JF - Journal of Antimicrobial Chemotherapy (JAC)
JA - J ANTIMICROB CHEMOTHER
VL - 64
IS - 4
PB - Oxford University Press / USA
SN - 0305-7453
AD - The State Food and Drug Administration, Beijing, People's Republic of China
U2 - PMID: 19684078.
DO - jac/dkp275
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105224322
T1 - Program and client characteristics as predictors of the availability of social support services in community-based substance abuse treatment programs.
AU - Delany PJ
AU - Shields JJ
AU - Roberts DL
AU - Delany, Peter J
AU - Shields, Joseph J
AU - Roberts, Dana L
Y1 - 2009/10//
N1 - Accession Number: 105224322. Language: English. Entry Date: 20100115. Revision Date: 20160528. Publication Type: journal article; research. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 9803531.
KW - Community Mental Health Services -- Administration
KW - Support, Psychosocial
KW - Substance Use Rehabilitation Programs -- Administration
KW - Substance Use Disorders -- Rehabilitation
KW - Community Mental Health Services -- Statistics and Numerical Data
KW - Female
KW - Health Services Accessibility
KW - Human
KW - Male
KW - Needs Assessment
KW - Substance Use Rehabilitation Programs -- Statistics and Numerical Data
SP - 450
EP - 464
JO - Journal of Behavioral Health Services & Research
JF - Journal of Behavioral Health Services & Research
JA - J BEHAV HEALTH SERV RES
VL - 36
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
AB - Recent emphases on increasing accountability, using less intensive settings, and implementing evidence-based services helped to focus the research community on the structure, processes, and outcomes of services delivered to substance abuse clients. Considerably less attention has been given to understanding how to structure services to enhance engagement and retention leading to treatment continuity. This study examined structural characteristics of community-based treatment facilities in relationship to the availability of supportive services within a sample of 1,332 substance abuse treatment programs surveyed through the Alcohol and Drug Services Study in 1996 and 1997. Structural and client characteristics are important predictors of added supportive services. Furthermore, a program with a broader and established set of core services is more likely to have expanded supportive services. These findings have implications for public health professionals, both in terms of ensuring sustainable service programming for these chronic clients and in identifying services to adopt or discard to meet a population with multiple needs.
SN - 1094-3412
AD - Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA
AD - Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA. peter.delany@samhsa.hhs.gov
U2 - PMID: 19082738.
DO - 10.1007/s11414-008-9153-z
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105434368
T1 - Ethnic health care advisors: a good strategy to improve the access to health care and social welfare services for ethnic minorities?
AU - Hesselink AE
AU - Verhoeff AP
AU - Stronks K
Y1 - 2009/10//
N1 - Accession Number: 105434368. Language: English. Entry Date: 20091106. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: Funded by ZonMw, the Netherlands organisation for health research and development. NLM UID: 7600747.
KW - Ethnic Groups
KW - Health Personnel
KW - Health Services Accessibility
KW - Minority Groups
KW - Social Work Service
KW - Action Research
KW - Adult
KW - Female
KW - Funding Source
KW - Male
KW - Medical Care
KW - Middle Age
KW - Netherlands
KW - Semi-Structured Interview
KW - Success
KW - Human
SP - 419
EP - 429
JO - Journal of Community Health
JF - Journal of Community Health
JA - J COMMUNITY HEALTH
VL - 34
IS - 5
CY - ,
PB - Springer Science & Business Media B.V.
AB - Empirical studies indicate that ethnic minorities have limited access to health care and welfare services compared with the host population. To improve this access, ethnic health care (HC) advisors were introduced in four districts in Amsterdam, the Netherlands. HC advisors work for all health care and welfare services and their main task is to provide information on health care and welfare to individuals and groups and refer individuals to services. Action research was carried out over a period of 2 years to find out whether and how this function can contribute to improve access to services for ethnic minorities. Information was gathered by semi-structured interviews, analysing registration forms and reports, and attending meetings. The function's implementation and characteristics differed per district. The ethnicity of the health care advisors corresponded to the main ethnic groups in the district: Moroccan and Turkish (three districts) and sub-Sahara African and Surinamese (one district). HC advisors reached many ethnic inhabitants (n = 2,224) through individual contacts. Half of them were referred to health care and welfare services. In total, 576 group classes were given. These were mostly attended by Moroccan and Turkish females. Outreach activities and office hours at popular locations appeared to be important characteristics for actually reaching ethnic minorities. Furthermore, direct contact with a well-organized back office seems to be important. HC advisors were able to reach many ethnic minorities, provide information about the health care and welfare system, and refer them to services. Besides adapting the function to the local situation, some general aspects for success can be indicated: the ethnic background of the HC advisor should correspond to the main ethnic minority groups in the district, HC advisors need to conduct outreach work, there must be a well-organized back office to refer clients to, and there needs to be enough commitment among professionals of local health and welfare services.
SN - 0094-5145
AD - Department of Epidemiology and Health Promotion, Public Health Service Amsterdam, 1000 CE Amsterdam, The Netherlands
U2 - PMID: 19718526.
DO - 10.1007/s10900-009-9171-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105434368&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - JONES, JESSICA L.
AU - NOE, KATHY E.
AU - BYARS, ROBIN
AU - DEPAOLA, AND ANGELO
T1 - Evaluation of DNA Colony Hybridization and Real-Time PCR for Detection of Vibrio parahaemolyticus and Vibrio vulnificus in Postharvest-Processed Oysters.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/10//
VL - 72
IS - 10
M3 - Article
SP - 2106
EP - 2109
SN - 0362028X
AB - The applicability of real-time PCR was examined for detection of vibrios from post-harvest-processed (PHP) oysters to allow for a more rapid assay and higher sample throughput than currently used. During June to October 2004, 68 PHP oyster samples were collected directly from PHP firms or from retail markets across the United States. PHP oysters were examined to determine the effectiveness of treatments in the reduction of vibrio levels and to compare the analytical methods utilized. The latter is the focus of the data presented here. Each sample was analyzed for Vibrio parahaemolyticus and V. vulnificus by using a 2-dilution, three-tube most-probable-number (MPN) and a 25-g presence/absence enrichment in alkaline peptone water. Following 6-h and overnight enrichment, aliquots from each MPN tube and the 25-g sample were streaked onto selective media and tested by real- time PCR. Colonies from the selective agar were confirmed as V. parahaemolyticus or V. vulnificus by DNA colony hybridization. DNA hybridization and real-time PCR results for each MPN tube and the 25-g enrichment at both time points were analyzed individually for each organism. The methods were in agreement for 857 (95%) of 901 and for 882 (98%) of 903 tubes for detection of V. parahaemolyticus and V. vulnificus, respectively. Overall, there was 96% agreement between real-time and DNA colony hybridization. The results obtained by real-time PCR were comparable to those from DNA colony hybridization, but analysis time was significantly reduced for the detection of vibrios in PHP-treated oysters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters
KW - Microbiological assay
KW - Hybridization
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - Polymerase chain reaction
KW - DNA
KW - United States
N1 - Accession Number: 44946829; JONES, JESSICA L. 1; Email Address: Jessica.Jones@fda.hhs.gov; NOE, KATHY E. 2; BYARS, ROBIN 2; DEPAOLA, AND ANGELO 1; Affiliations: 1: U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphiti Island, Alabama 36528; 2: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, Georgia 30309, USA; Issue Info: Oct2009, Vol. 72 Issue 10, p2106; Thesaurus Term: Oysters; Thesaurus Term: Microbiological assay; Thesaurus Term: Hybridization; Subject Term: Vibrio parahaemolyticus; Subject Term: Vibrio vulnificus; Subject Term: Polymerase chain reaction; Subject Term: DNA; Subject: United States; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - JONES, JESSICA L.
AU - NOE, KATHY E.
AU - BYARS, ROBIN
AU - DEPAOLA, AND ANGELO
T1 - Evaluation of DNA Colony Hybridization and Real-Time PCR for Detection of Vibrio parahaemolyticus and Vibrio vulnificus in Postharvest-Processed Oysters.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/10//
VL - 72
IS - 10
M3 - Article
SP - 2106
EP - 2109
SN - 0362028X
AB - The applicability of real-time PCR was examined for detection of vibrios from post-harvest-processed (PHP) oysters to allow for a more rapid assay and higher sample throughput than currently used. During June to October 2004, 68 PHP oyster samples were collected directly from PHP firms or from retail markets across the United States. PHP oysters were examined to determine the effectiveness of treatments in the reduction of vibrio levels and to compare the analytical methods utilized. The latter is the focus of the data presented here. Each sample was analyzed for Vibrio parahaemolyticus and V. vulnificus by using a 2-dilution, three-tube most-probable-number (MPN) and a 25-g presence/absence enrichment in alkaline peptone water. Following 6-h and overnight enrichment, aliquots from each MPN tube and the 25-g sample were streaked onto selective media and tested by real- time PCR. Colonies from the selective agar were confirmed as V. parahaemolyticus or V. vulnificus by DNA colony hybridization. DNA hybridization and real-time PCR results for each MPN tube and the 25-g enrichment at both time points were analyzed individually for each organism. The methods were in agreement for 857 (95%) of 901 and for 882 (98%) of 903 tubes for detection of V. parahaemolyticus and V. vulnificus, respectively. Overall, there was 96% agreement between real-time and DNA colony hybridization. The results obtained by real-time PCR were comparable to those from DNA colony hybridization, but analysis time was significantly reduced for the detection of vibrios in PHP-treated oysters. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VIBRIO parahaemolyticus
KW - VIBRIO vulnificus
KW - OYSTERS
KW - POLYMERASE chain reaction
KW - MICROBIOLOGICAL assay
KW - DNA
KW - HYBRIDIZATION
KW - UNITED States
N1 - Accession Number: 44946829; JONES, JESSICA L. 1; Email Address: Jessica.Jones@fda.hhs.gov NOE, KATHY E. 2 BYARS, ROBIN 2 DEPAOLA, AND ANGELO 1; Affiliation: 1: U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphiti Island, Alabama 36528 2: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, Georgia 30309, USA; Source Info: Oct2009, Vol. 72 Issue 10, p2106; Subject Term: VIBRIO parahaemolyticus; Subject Term: VIBRIO vulnificus; Subject Term: OYSTERS; Subject Term: POLYMERASE chain reaction; Subject Term: MICROBIOLOGICAL assay; Subject Term: DNA; Subject Term: HYBRIDIZATION; Subject Term: UNITED States; NAICS/Industry Codes: 112510 Aquaculture; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - DEPAOLA, ANGELO
AU - JONES, JESSICA L.
AU - NOE, KATHY E.
AU - BYARS, ROBIN H.
AU - BOWERS, JOHN C.
T1 - Survey of Postharvest-Processed Oysters in the United States of Levels of Vibrio vulnificus and Vibrio parahaernolyticus.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/10//
VL - 72
IS - 10
M3 - Article
SP - 2110
EP - 2113
SN - 0362028X
AB - From June through October 2004, the U.S. Food and Drug Administration collected oysters (61 samples) that had been subjected to postharvest processing (PHP) methods, including mild heat treatment, freezing, and high hydrostatic pressure, from processors and retail markets in various states to determine Vibrio vulnificus and V. parahaemolyticus levels. Presence in a 25-g sample and most probable number (MPN) using standard enrichment and selective isolation procedures were utilized. Suspect colonies were isolated and identified using DNA probe colony hybridization. Neither species of vibrio was detected in 25-g portions of most samples regardless of the PHP. The lowest frequency of isolation of either pathogen (< 10%) was observed with the mild heat process. Few (12 to 13%) frozen samples collected at the processor but not at retail contained >30 MPN/g of either pathogen. The mean levels of either organism in PHP oysters observed in the present study were 5 to 6 log less than in unprocessed raw Gulf Coast oysters. Of the 70 V. vulnificus isolates examined, only 5 possessed the putative virulence marker, type B 16S rRNA. Neither the thermostable direct hemolysin (tdh) nor the tdh-related hemolysin (trh) virulence gene was detected in any of the 40 V. parahaemolyticus isolates examined in the present study. These data suggest that if there is any selective advantage to pathogenic strains of V. vulnificus and V. parahaemolyticus, these differences are minimal. These results indicate that all PHP treatments greatly reduce exposure of V. vulnificus and V. parahaemolyticus to raw-oyster consumers. Consequently, these PHP oysters pose a much lower risk of illness to consumers due to these pathogens. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Oysters
KW - Hybridization
KW - Vibrio parahaemolyticus
KW - Vibrio vulnificus
KW - DNA probes
KW - United States
KW - United States. Food & Drug Administration
N1 - Accession Number: 44946830; DEPAOLA, ANGELO 1; Email Address: angelo.depaola@fda.hhs.gov; JONES, JESSICA L. 1; NOE, KATHY E. 2; BYARS, ROBIN H. 2; BOWERS, JOHN C. 3; Affiliations: 1: U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528; 2: U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, Georgia 30309; 3: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Public Health and Biostatistics, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA; Issue Info: Oct2009, Vol. 72 Issue 10, p2110; Thesaurus Term: Oysters; Thesaurus Term: Hybridization; Subject Term: Vibrio parahaemolyticus; Subject Term: Vibrio vulnificus; Subject Term: DNA probes; Subject: United States ; Company/Entity: United States. Food & Drug Administration; NAICS/Industry Codes: 112512 Shellfish Farming; NAICS/Industry Codes: 114113 Salt water fishing; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 112510 Aquaculture; Number of Pages: 4p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - YANG HONG
AU - TONGRUI LIU
AU - LEE, MARGIE D.
AU - HOFACRE, CHARLES L.
AU - MAIER, MARIE
AU - AYERS, SHERRY
AU - WANG, LIHUA
AU - BERGHAUS, ROY
AU - MAURER, JOHN
AU - WHITE, DAVID G.
T1 - A Rapid Screen of Broth Enrichments for Salmonella enterica Serovars Enteritidis, Hadar, Heidelberg, and Typhimurium by Using an Allelotyping Multiplex PCR That Targets O- and H-Antigen Alleles.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/10//
VL - 72
IS - 10
M3 - Article
SP - 2198
EP - 2201
SN - 0362028X
AB - Salmonella continues to cause significant foodborne outbreaks, best illustrated with recent outbreaks associated with peanut butter, raw tomatoes, and serrano peppers. To ascertain the likely source of the outbreak, bacterial typing is essential to this process. While PCR has become an important detection tool for pathogens in foods, PCR can also identify strain differences by targeting gene(s) or sequences exhibiting polymorphisms or variability in its distribution within the bacterial population. Over 2,500 Salmonella enterica serovars identified based on antigenic differences in lipopolysaccharide and flagellin have been identified to date. We developed an allelotyping PCR scheme that identifies the O and H alleles associated with S. enterica serovars Enteritidis, Hadar, Heidelberg, Typhimurium, and others, with the same antigen alleles but in different O- and H-allele combinations (e.g., S. enterica Kentucky), and validated it as a screen to identify samples contaminated with these Salmonella serovars. We correctly identified poultry samples containing S. enterica serovars Enteritidis, Kentucky, and Typhimurium from our multiplex screen of primary enrichments of environmental drag swabs. PCR agreed well (kappa values = 0.81 to 1.0) with conventional serotyping methods used to type salmonellae isolated from primary enrichment. Coupled with Salmonella-specific PCR, such as invA, this allelotyping PCR could prove useful in the identification of Salmonella and specific S. enterica serovars present in foods or the environment and could decrease the time and cost associated with conventional serotyping methods. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food pathogens
KW - Epidemics
KW - Serotyping
KW - Salmonella enteritidis
KW - Salmonella typhimurium
KW - Genetic polymorphisms
KW - Polymerase chain reaction
N1 - Accession Number: 44946842; YANG HONG 1,2; TONGRUI LIU 1; LEE, MARGIE D. 1,3; HOFACRE, CHARLES L. 1,3; MAIER, MARIE 1; AYERS, SHERRY 4; WANG, LIHUA 5; BERGHAUS, ROY 1; MAURER, JOHN 1,3; Email Address: jmaurer@uga.edu; WHITE, DAVID G. 4; Affiliations: 1: Department of Population Health, The University of Georgia, Athens, Georgia 30602; 2: Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602; 3: Center for Food Safety and Quality Enhancement, College of Agriculture and Environmental Sciences, The University of Georgia, Griffin, Georgia 30223; 4: Center for Veterinary Medicine, U.S. Food Drug Administration, Laurel, Maryland 20708, USA; 5: Department of Statistics, School of Arts and Science, The University of Georgia, Athens, Georgia 30602; Issue Info: Oct2009, Vol. 72 Issue 10, p2198; Thesaurus Term: Food pathogens; Thesaurus Term: Epidemics; Subject Term: Serotyping; Subject Term: Salmonella enteritidis; Subject Term: Salmonella typhimurium; Subject Term: Genetic polymorphisms; Subject Term: Polymerase chain reaction; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - PRINCIPATO, MARYANN
AU - BOYLE, THOMAS
AU - NJOROGE, JOYCE
AU - JONES JR., ROBERT L.
AU - O'DONNELL, MICHAEL
T1 - Effect of Thermal Processing during Yogurt Production upon the Detection of Staphylococcal Enterotoxin B.
JO - Journal of Food Protection
JF - Journal of Food Protection
Y1 - 2009/10//
VL - 72
IS - 10
M3 - Article
SP - 2212
EP - 2216
SN - 0362028X
AB - This research was conducted to examine the inherent properties of yogurt contaminated with staphylococcal enterotoxin B (SEB). Two types of yogurts were produced for this study. Type I yogurts were produced by adding SEB at the start of yogurt production, and type II yogurts were produced by adding SEB after the milk base had been boiled. Biochemical characteristics inherent to yogurt, including pH, lactic acid and acetaldehyde concentrations, were analyzed weekly for each batch beginning at a time just after production and throughout a storage period of at least 4 weeks. The presence of toxin during yogurt production did not result in any significant biochemical or physical changes in yogurt. However, we were unable to detect SEB toxin in type I yogurt using a commercially available enzyme-linked immunosorbent assay (ELISA). In contrast, SEB was easily detectable by our ELISA in type II yogurt samples. Higher levels of SEB were recovered from type II yogurt that had been stored for 1 week than from type II yogurt that had been stored for any other length of time. These results indicate that the biochemical characteristics of yogurt did not change significantly (relative to control yogurt) in the presence of either thermally processed SEB or native SEB. However, the ability to detect SEB by ELISA was dependent on whether the toxin had been processed. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Food Protection is the property of Allen Press Publishing Services Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food contamination
KW - Effect of heat on food
KW - Yogurt
KW - Enterotoxins
KW - Staphylococcus
N1 - Accession Number: 44946845; PRINCIPATO, MARYANN 1; Email Address: maryann.principato@fda.hhs.gov; BOYLE, THOMAS 1; NJOROGE, JOYCE 1; JONES JR., ROBERT L. 1; O'DONNELL, MICHAEL 2; Affiliations: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 8301 Muirkirk Road, Laurel, Maryland 20708; 2: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20708, USA; Issue Info: Oct2009, Vol. 72 Issue 10, p2212; Thesaurus Term: Food contamination; Subject Term: Effect of heat on food; Subject Term: Yogurt; Subject Term: Enterotoxins; Subject Term: Staphylococcus; NAICS/Industry Codes: 413120 Dairy and milk products merchant wholesalers; NAICS/Industry Codes: 311511 Fluid Milk Manufacturing; NAICS/Industry Codes: 424430 Dairy Product (except Dried or Canned) Merchant Wholesalers; Number of Pages: 5p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Norton, Hillary E.
AU - Redd, John T.
AU - Bryan, Ralph T.
T1 - Hepatitis C Diagnoses in an American Indian Primary Care Population.
JO - Journal of Health Disparities Research & Practice
JF - Journal of Health Disparities Research & Practice
Y1 - 2009///Fall2009
VL - 3
IS - 2
M3 - Article
SP - 59
EP - 66
AB - BACKGROUND: Despite large disparities in the burden of chronic liver disease, data on hepatitis C virus (HCV) infection among American Indians (AIs) are lacking. We reviewed hepatitis C diagnoses in 35,712 AI/AN primary care patients. MAIN FINDINGS: At least one HCV-associated ICD-9 code was recorded in 251 (1%) patients between October 1, 2001 and September 30, 2003. An HCV enzyme-linked immunoassay (HCVEIA) was sent in 209 (83.0%); 206/209 (99%) were positive. Confirmatory testing was performed in 144/206 (70%) HCV-EIA positive patients; HCV infection was confirmed in 144 (100%). In the 90/144 (63%) charts with risk factor documentation, injection drug use was the most common risk factor (61/90, 68%). Deficiencies were present in hepatitis B and HIV testing, and hepatitis A and B vaccination. PRINCIPAL CONCLUSIONS: Improvements in laboratory workup of HCV and co-infections, risk factor ascertainment and documentation, and adult vaccination are needed to address HCV effectively in this population. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Health Disparities Research & Practice is the property of Center for Health Disparities & Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C -- Diagnosis
KW - NATIVE Americans
KW - PRIMARY care (Medicine)
KW - ENZYME-linked immunosorbent assay
KW - LIVER diseases
KW - DISEASES -- Risk factors
KW - Community/public health
KW - Infectious Disease
KW - Primary Care Issues
KW - Special population: Native American/First Nations
N1 - Accession Number: 53453978; Norton, Hillary E. 1 Redd, John T. 2 Bryan, Ralph T. 2; Affiliation: 1: University of New Mexico School of Medicine 2: Indian Health Service, Centers for Disease Control and Prevention; Source Info: Fall2009, Vol. 3 Issue 2, p59; Subject Term: HEPATITIS C -- Diagnosis; Subject Term: NATIVE Americans; Subject Term: PRIMARY care (Medicine); Subject Term: ENZYME-linked immunosorbent assay; Subject Term: LIVER diseases; Subject Term: DISEASES -- Risk factors; Author-Supplied Keyword: Community/public health; Author-Supplied Keyword: Infectious Disease; Author-Supplied Keyword: Primary Care Issues; Author-Supplied Keyword: Special population: Native American/First Nations; Number of Pages: 8p; Illustrations: 1 Chart, 1 Graph; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van de Laar, Thijs J.W.
AU - Molenkamp, Richard
AU - van den Berg, Charlotte
AU - Schinkel, Janke
AU - Beld, Marcel G.H.M.
AU - Prins, Maria
AU - Coutinho, Roel A.
AU - Bruisten, Sylvia M.
T1 - Frequent HCV reinfection and superinfection in a cohort of injecting drug users in Amsterdam
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009/10//
VL - 51
IS - 4
M3 - Article
SP - 667
EP - 674
SN - 01688278
AB - Background/Aims: This study investigates the occurrence of HCV reinfection and superinfection among HCV seroconverters participating in the Amsterdam Cohort Studies among drug users from 1985 through 2005. Methods: HCV seroconverters (n =59) were tested for HCV RNA at five different time points: the last visit before seroconversion (t =−1), the first visit after seroconversion (t =1), six months after (t =2) and one year after (t =3) seroconversion, and the last visit prior to November 2005 (t =4). If HCV RNA was present, part of the NS5B region was amplified and sequenced. Additional phylogenetic analysis and cloning was performed to establish HCV reinfection and superinfection. Results: Multiple HCV infections were detected in 23/59 (39%) seroconverters; 7 had HCV reinfections, 14 were superinfected, and 2 had reinfection followed by superinfection. At the moment of HCV reinfection, 7/9 seroconverters were HIV-negative: persistent HCV reinfection developed in both HIV-positive cases but also in 4/7 HIV-negative cases. In total, we identified 93 different HCV infections, varying from 1 to 4 infections per seroconverter. Multiple HCV infections were observed in 10/24 seroconverters with spontaneous HCV clearance (11 reinfections, 3 superinfections) and in 13/35 seroconverters without viral clearance (20 superinfections). Conclusions: HCV reinfection and superinfection are common among actively injecting drug users. This might further complicate the development of an effective HCV vaccine. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hepatology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS C virus
KW - VIRUS diseases
KW - COHORT analysis
KW - SEROCONVERSION
KW - RNA viruses
KW - INJECTIONS
KW - AMSTERDAM (Netherlands)
KW - NETHERLANDS
KW - Amsterdam cohort studies ( ACS )
KW - drug users ( DU )
KW - Epidemiology
KW - HCV
KW - hepatitis C virus ( HCV )
KW - human immunodeficiency virus ( HIV )
KW - Immune protection
KW - Injecting drug use
KW - person years ( PY )
KW - Phylogeny
KW - polymerase chain reaction ( PCR )
KW - Reinfection
KW - Superinfection
N1 - Accession Number: 44173183; van de Laar, Thijs J.W. 1,2; Email Address: tvdlaar@ggd.amsterdam.nl Molenkamp, Richard 3 van den Berg, Charlotte 1,2 Schinkel, Janke 3 Beld, Marcel G.H.M. 3 Prins, Maria 1,2 Coutinho, Roel A. 1,2,4 Bruisten, Sylvia M. 1,2; Affiliation: 1: Cluster of Infectious Diseases, Public Health Service, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands 2: Department of Internal Medicine, Centre for Infection and Immunity Amsterdam (CINIMA), Academic Medical Centre, Amsterdam, The Netherlands 3: Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands 4: Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Source Info: Oct2009, Vol. 51 Issue 4, p667; Subject Term: HEPATITIS C virus; Subject Term: VIRUS diseases; Subject Term: COHORT analysis; Subject Term: SEROCONVERSION; Subject Term: RNA viruses; Subject Term: INJECTIONS; Subject Term: AMSTERDAM (Netherlands); Subject Term: NETHERLANDS; Author-Supplied Keyword: Amsterdam cohort studies ( ACS ); Author-Supplied Keyword: drug users ( DU ); Author-Supplied Keyword: Epidemiology; Author-Supplied Keyword: HCV; Author-Supplied Keyword: hepatitis C virus ( HCV ); Author-Supplied Keyword: human immunodeficiency virus ( HIV ); Author-Supplied Keyword: Immune protection; Author-Supplied Keyword: Injecting drug use; Author-Supplied Keyword: person years ( PY ); Author-Supplied Keyword: Phylogeny; Author-Supplied Keyword: polymerase chain reaction ( PCR ); Author-Supplied Keyword: Reinfection; Author-Supplied Keyword: Superinfection; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.jhep.2009.07.002
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Fleischer, Russell D.
AU - Lok, Anna S.F.
T1 - Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B
JO - Journal of Hepatology
JF - Journal of Hepatology
Y1 - 2009/10//
VL - 51
IS - 4
M3 - Article
SP - 787
EP - 791
SN - 01688278
AB - The development of clevudine as a treatment for hepatitis B was terminated recently because of case reports of myopathy. In each case, the onset of symptoms occurred between 8 and 13 months after the initiation of treatment. Electromyography and muscle biopsy confirmed the presence of myonecrosis. One report also found evidence of mitochondrial toxicity. The delayed onset and the finding of mitochondrial damage are reminiscent of fialuridine toxicity. Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon. These findings serve as a sober reminder of the lack of data on long-term safety of nucleos(t)ide analogs for hepatitis B, the importance of balancing benefits versus risks before initiating treatment, and the need for more stringent post-marketing surveillance for drug toxicities. [Copyright &y& Elsevier]
AB - Copyright of Journal of Hepatology is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MUSCLES -- Diseases
KW - NEUROPATHY
KW - ANTIVIRAL nucleosides
KW - HEPATITIS B -- Treatment
KW - ANTIVIRAL agents
KW - ELECTROMYOGRAPHY
KW - DRUGS -- Toxicology
KW - BIOPSY
KW - Clevudine
KW - Mitochondrial toxicity
KW - Pegylated interferon
KW - Telbivudine
N1 - Accession Number: 44173197; Fleischer, Russell D. 1 Lok, Anna S.F. 2; Email Address: aslok@umich.edu; Affiliation: 1: Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA 2: Division of Gastroenterology and Hepatology, University of Michigan Health System, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109, USA; Source Info: Oct2009, Vol. 51 Issue 4, p787; Subject Term: MUSCLES -- Diseases; Subject Term: NEUROPATHY; Subject Term: ANTIVIRAL nucleosides; Subject Term: HEPATITIS B -- Treatment; Subject Term: ANTIVIRAL agents; Subject Term: ELECTROMYOGRAPHY; Subject Term: DRUGS -- Toxicology; Subject Term: BIOPSY; Author-Supplied Keyword: Clevudine; Author-Supplied Keyword: Mitochondrial toxicity; Author-Supplied Keyword: Pegylated interferon; Author-Supplied Keyword: Telbivudine; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.jhep.2009.06.011
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105443233
T1 - Healthcare quality and disparities: attacking problems at their root.
AU - Clancy CM
Y1 - 2009/10//2009 Oct-Dec
N1 - Accession Number: 105443233. Language: English. Entry Date: 20091030. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Quality Assurance. NLM UID: 9200672.
KW - Health Services Accessibility
KW - Quality of Health Care
KW - Health Care Delivery
KW - Health Care Reform
KW - Health Information Systems
KW - Patient Safety
KW - Quality Improvement
KW - Reports
KW - Social Environment
KW - United States Agency for Healthcare Research and Quality
SP - 269
EP - 272
JO - Journal of Nursing Care Quality
JF - Journal of Nursing Care Quality
JA - J NURS CARE QUAL
VL - 24
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
SN - 1057-3631
AD - Agency for Healthcare Research and Quality, 540 Gaither Rd, Rockville, MD 20850, USA;
U2 - PMID: 19755876.
DO - 10.1097/NCQ.0b013e3181b1b819
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105443233&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Torma-Krajewski, Janet
AU - Wiehagen, William
AU - Etcheverry, Ann
AU - Turin, Fred
AU - Unger, Richard
T1 - Ergonomics.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/10//
VL - 6
IS - 10
M3 - Article
SP - 55
EP - 62
PB - Taylor & Francis Ltd
SN - 15459624
AB - Job tasks that involve exposure to work-related musculoskeletal disorder (WMSD) risk factors may impact both the risk of injury and production downtime. Common WMSD risks factors associated with mining tasks include forceful exertions, awkward postures, repetitive motion, jolting and jarring, forceful gripping, contact stress, and whole body and segmental vibration. Mining environments that expose workers to temperature/humidity extremes, windy conditions, and slippery and uneven walking surfaces also contribute to injury risk. National Institute for Occupational Safety and Health (NIOSH) researchers worked with powder crew members from the Bridger Coal Company to identify and rank routine work tasks based on perceived exposure to WMSD risk factors. This article presents the process followed to identify tasks that workers believed involved the greatest exposure to risk factors and discusses risk reduction strategies. Specifically, the proposed prill truck design changes addressed cab ingress/egress, loading blast holes, and access to the upper deck of the prill truck. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES
KW - Industrial safety
KW - Ergonomics
KW - Work environment
KW - Musculoskeletal system
KW - United States
KW - ergonomics
KW - mining
KW - MSD risk factors
KW - National Institute for Occupational Safety & Health
N1 - Accession Number: 75127878; Torma-Krajewski, Janet 1; Wiehagen, William 2; Etcheverry, Ann 3; Turin, Fred 2; Unger, Richard 2; Affiliations: 1: Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health (NIOSH), Arvada, Colorado,Colorado School of Mines, Golden, Colorado; 2: Pittsburgh Research Laboratory, NIOSH, Pittsburgh, Pennsylvania; 3: Point of Rocks, Bridger Coal Company, Wyoming,EnCana, Rock Springs, Wyoming; Issue Info: Oct2009, Vol. 6 Issue 10, p55; Thesaurus Term: DISEASES; Thesaurus Term: Industrial safety; Subject Term: Ergonomics; Subject Term: Work environment; Subject Term: Musculoskeletal system; Subject: United States; Author-Supplied Keyword: ergonomics; Author-Supplied Keyword: mining; Author-Supplied Keyword: MSD risk factors ; Company/Entity: National Institute for Occupational Safety & Health; Number of Pages: 8p; Illustrations: 7 Charts; Document Type: Article
L3 - 10.1080/15459620903146636
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=75127878&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105443724
T1 - Using ergonomics to enhance safe production at a surface coal mine -- a case study with powder crews.
AU - Torma-Krajewski J
AU - Wiehagen W
AU - Etcheverry A
AU - Turin F
AU - Unger R
Y1 - 2009/10//
N1 - Accession Number: 105443724. Language: English. Entry Date: 20091009. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Evidence-Based Practice. NLM UID: 101189458.
KW - Ergonomics -- Methods
KW - Mining
KW - Musculoskeletal Diseases -- Prevention and Control
KW - Occupational Diseases -- Prevention and Control
KW - Safety -- Standards
KW - Accidents, Occupational -- Prevention and Control
KW - Adult
KW - Case Studies
KW - Interviews
KW - Occupational Health
KW - Risk Factors
KW - Task Performance and Analysis
KW - Human
SP - D55
EP - 62
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 10
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - Job tasks that involve exposure to work-related musculoskeletal disorder (WMSD) risk factors may impact both the risk of injury and production downtime. Common WMSD risks factors associated with mining tasks include forceful exertions, awkward postures, repetitive motion, jolting and jarring, forceful gripping, contact stress, and whole body and segmental vibration. Mining environments that expose workers to temperature/humidity extremes, windy conditions, and slippery and uneven walking surfaces also contribute to injury risk. National Institute for Occupational Safety and Health (NIOSH) researchers worked with powder crew members from the Bridger Coal Company to identify and rank routine work tasks based on perceived exposure to WMSD risk factors. This article presents the process followed to identify tasks that workers believed involved the greatest exposure to risk factors and discusses risk reduction strategies. Specifically, the proposed prill truck design changes addressed cab ingress/egress, loading blast holes, and access to the upper deck of the prill truck.
SN - 1545-9624
AD - Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health, Arvada, CO, USA
U2 - PMID: 19626526.
DO - 10.1080/15459620903146636
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105443724&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Fuente, Adrian
AU - Slade, Martin D.
AU - Taylor, Tanisha
AU - Morata, Thais C.
AU - Keith, Robert W.
AU - Sparer, Judy
AU - Rabinowitz, Peter M.
T1 - Peripheral and Central Auditory Dysfunction Induced by Occupational Exposure to Organic Solvents.
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
Y1 - 2009/10//
VL - 51
IS - 10
M3 - Article
SP - 1202
EP - 1211
SN - 10762752
AB - The article presents a study which aims to examine the effect of solvent exposure on hearing function among a group of people not occupationally exposed to high levels of noise. It mentions that multiple regression models were used to explore the association of solvent exposures to hearing outcomes. It affirms that the authors utilize the dichotic digits test to detect central auditory dysfunction in the research.
KW - NOISE
KW - MULTIPLE regression analysis
KW - HEARING disorders
KW - INDUSTRIAL toxicology
KW - OCCUPATIONAL diseases
N1 - Accession Number: 45032552; Fuente, Adrian 1; Email Address: afuente@med.uchile.cl Slade, Martin D. 2 Taylor, Tanisha 2 Morata, Thais C. 3 Keith, Robert W. 4 Sparer, Judy 2 Rabinowitz, Peter M. 2; Affiliation: 1: Escuela de Fonoaudiologia [School of Speech and Hearing Sciences], Medical Faculty, Universidad de Chile, Santiago, Chile 2: Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Conn. 3: Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio 4: Division of Audiology, University of Cincinnati, Cincinnati, Ohio; Source Info: Oct2009, Vol. 51 Issue 10, p1202; Subject Term: NOISE; Subject Term: MULTIPLE regression analysis; Subject Term: HEARING disorders; Subject Term: INDUSTRIAL toxicology; Subject Term: OCCUPATIONAL diseases; Number of Pages: 10p; Illustrations: 6 Charts, 1 Graph; Document Type: Article
L3 - 10.1097/JOM.0b013e3181bae17c
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45032552&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Spencer, John A.
AU - Kauffman, John F.
AU - Reepmeyer, John C.
AU - Gryniewicz, Connie M.
AU - Ye, Wei
AU - Toler, Duckhee Y.
AU - Buhse, Lucinda F.
AU - Westenberger, Benjamin J.
T1 - Screening of heparin API by near infrared reflectance and Raman spectroscopy.
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
Y1 - 2009/10//
VL - 98
IS - 10
M3 - Article
SP - 3540
EP - 3547
SN - 00223549
AB - Near infrared (NIR) reflectance and laser Raman spectra for a set of 69 heparin powder samples obtained from several foreign and domestic suppliers were measured. Both the NIR and Raman spectra of individual heparin API powder samples were correlated with sample compositions determined from response corrected relative peak areas of the capillary electropherograms of the samples using a partial least squares (PLS) regression model. Twenty-eight sample spectra were used to develop PLS models for the three major sample components; heparin, oversulfated chondroitin sulfate (OSCS) and glycosaminoglycans (GAGs). The PLS models were then used to successfully predict the compositions of 41 additional heparin samples. The success of these rapid, nondestructive technologies to identify contamination of heparin with OSCS demonstrates the potential of spectroscopy and chemometrics for screening of processed raw materials. These technologies are meant for screening purposes and not meant to replace either of the methods (capillary electrophoresis and NMR) currently required by USP and FDA. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3540–3547, 2009 [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Pharmaceutical Sciences is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPARIN
KW - RAMAN spectroscopy
KW - RAMAN effect
KW - CHONDROITIN sulfates
KW - GLYCOSAMINOGLYCANS
KW - SPECTRAL reflectance
KW - REGRESSION analysis
KW - CHEMOMETRICS
KW - chemometrics
KW - heparin
KW - near infrared
KW - oversulfated chondroitin sulfate (OSCS)
KW - partial least squares (PLS)
KW - Raman
N1 - Accession Number: 43949638; Spencer, John A. 1; Email Address: john.spencer@fda.hhs.gov Kauffman, John F. 1 Reepmeyer, John C. 1 Gryniewicz, Connie M. 1 Ye, Wei 1 Toler, Duckhee Y. 1 Buhse, Lucinda F. 1 Westenberger, Benjamin J. 1; Affiliation: 1: Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, Missouri 63101; Source Info: Oct2009, Vol. 98 Issue 10, p3540; Subject Term: HEPARIN; Subject Term: RAMAN spectroscopy; Subject Term: RAMAN effect; Subject Term: CHONDROITIN sulfates; Subject Term: GLYCOSAMINOGLYCANS; Subject Term: SPECTRAL reflectance; Subject Term: REGRESSION analysis; Subject Term: CHEMOMETRICS; Author-Supplied Keyword: chemometrics; Author-Supplied Keyword: heparin; Author-Supplied Keyword: near infrared; Author-Supplied Keyword: oversulfated chondroitin sulfate (OSCS); Author-Supplied Keyword: partial least squares (PLS); Author-Supplied Keyword: Raman; Number of Pages: 8p; Document Type: Article
L3 - 10.1002/jps.21660
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43949638&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, David L.
T1 - Use of l-cysteine for minimization of inorganic Hg loss during thermal neutron irradiation.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2009/10//
VL - 282
IS - 1
M3 - Article
SP - 11
EP - 14
SN - 02365731
AB - Thermal neutron irradiation experiments performed with cellulose-based l-cysteine-treated and untreated Hg standards showed Hg losses of 59–81% for untreated standards but only about a 0.2% loss for treated standards. These results and others for multielement standards showed that Hg loss is highly dependent on total mass and placement of materials in the irradiation vessel and that distribution of volatilized Hg was fairly uniform throughout the sample-containing region of the vessel. Polyethylene trapped volatile Hg much more efficiently than cellulose and a multielement standard containing inorganic Se selectively trapped Hg lost from a co-irradiated multielement standard containing Hg. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUTRON irradiation
KW - CELLULOSE
KW - CYSTATHIONINE gamma-lyase
KW - PARTICLES (Nuclear physics)
KW - POLYETHYLENE
KW - INAA
KW - L-cysteine
KW - Mercury
N1 - Accession Number: 44729523; Anderson, David L. 1; Email Address: david.anderson@fda.hhs.gov; Affiliation: 1: Chemical Contaminants Branch (HFS-716), Office of Regulatory Science, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.; Source Info: Oct2009, Vol. 282 Issue 1, p11; Subject Term: NEUTRON irradiation; Subject Term: CELLULOSE; Subject Term: CYSTATHIONINE gamma-lyase; Subject Term: PARTICLES (Nuclear physics); Subject Term: POLYETHYLENE; Author-Supplied Keyword: INAA; Author-Supplied Keyword: L-cysteine; Author-Supplied Keyword: Mercury; Number of Pages: 4p; Illustrations: 3 Charts; Document Type: Article
L3 - 10.1007/s10967-009-0160-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44729523&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Anderson, David L.
T1 - Analytical capabilities of anticoincidence INAA for biological materials.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2009/10//
VL - 282
IS - 1
M3 - Article
SP - 75
EP - 79
SN - 02365731
AB - Sensitivities and limits of detection (LODs) for 39 elements were determined for cellulose filters, foods, and biological reference materials by anticoincidence instrumental neutron activation analysis. Compton background reduction improved many LODs by about a factor of 2, but increased LODs for elements whose radioisotopes decay with cascading γ-rays. As and Hg analyses were aided by reduction of Br and Se photopeak intensities, respectively. LODs of 0.03–0.8 μg/kg were achieved for 16 elements in cellulose filters. Typical biological material and food LODs were higher by factors of about 10–600. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DEMODULATION (Electronics)
KW - NUCLEAR activation analysis
KW - ANTICOINCIDENCE counting
KW - RADIOISOTOPES
KW - COMPTON electrons
KW - Anticoincidence INAA
KW - Biologicals
KW - LODs
N1 - Accession Number: 44729524; Anderson, David L. 1; Email Address: david.anderson@fda.hhs.gov; Affiliation: 1: Chemical Contaminants Branch (HFS-716), Office of Regulatory Science, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA.; Source Info: Oct2009, Vol. 282 Issue 1, p75; Subject Term: DEMODULATION (Electronics); Subject Term: NUCLEAR activation analysis; Subject Term: ANTICOINCIDENCE counting; Subject Term: RADIOISOTOPES; Subject Term: COMPTON electrons; Author-Supplied Keyword: Anticoincidence INAA; Author-Supplied Keyword: Biologicals; Author-Supplied Keyword: LODs; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 5p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s10967-009-0162-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44729524&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Galson, Steven K.
T1 - Improving Nutrition for Older Americans
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
Y1 - 2009/10//
VL - 109
IS - 10
M3 - Editorial
SP - 1672
EP - 1672
SN - 00028223
N1 - Accession Number: 44417889; Galson, Steven K. 1; Affiliation: 1: Acting US Surgeon General, US Department of Health and Human Services; Source Info: Oct2009, Vol. 109 Issue 10, p1672; Number of Pages: 1p; Document Type: Editorial
L3 - 10.1016/j.jada.2009.08.025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44417889&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kobayashi, Kenichi
AU - Yamamoto, Kazutoshi
AU - Kikuyama, Sakae
AU - Machida, Takeo
AU - Kobayashi, Tetsuya
T1 - Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice.
JO - Journal of Toxicologic Pathology
JF - Journal of Toxicologic Pathology
Y1 - 2009/10//
VL - 22
IS - 3
M3 - Article
SP - 187
EP - 194
SN - 09149198
AB - Congenitally primary hypothyroid growth-retarded (grt) mice exhibit a characteristic growth pause followed by delayed onset of pubertal growth. We characterized the developmental pattern of somatotropes, lactotropes and thyrotropes in the anterior pituitary, as well as plasma levels of their secretory hormones, in grt mice. Compared with normal mice, the weight of grt pituitary gland was similar at 8 weeks of age but significantly heavier after 12 weeks of age. Compared with normal mice, there were significantly fewer somatotropes in the grt pituitary until 8 weeks of age, but the number gradually increased up to 48 weeks. The number of lactotropes in grt mice was consistently lower than that in normal mice from 2 through 48 weeks, whereas the number of thyrotropes in the grt pituitary was consistently higher than in the normal pituitary. Thyrotropes in the grt pituitary exhibited hypertrophy and hyperplasia with less intensive thyroid-stimulating hormone (TSH) immunoreactivity than normal thyrotropes. In normal mice, the sum of the relative proportions of these cells plateaued at 8 weeks, where it remained up to 48 weeks of age. In grt mice, these proportions almost reached normal levels at 12 weeks of age but gradually declined after 24 weeks. Plasma growth hormone concentrations did not differ between grt and normal mice until 24 weeks of age. Compared with normal mice, grt mice exhibited significantly lower plasma prolactin and thyroxine levels but higher TSH levels. These findings indicate that development of somatotropes, lactotropes and thyrotropes in grt mice is impaired, being followed by altered hormone secretion. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicologic Pathology is the property of Japanese Society of Toxicologic Pathology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HYPOTHYROIDISM
KW - MICE as laboratory animals
KW - SOMATOTROPIN
KW - PITUITARY gland
KW - HYPERTROPHY
KW - HYPERPLASIA
KW - THYROTROPIN
KW - PROLACTIN
KW - THYROXINE
KW - anterior pituitary
KW - grt mouse
KW - lactotrope
KW - somatotrope
KW - thyrotrope
N1 - Accession Number: 44768315; Kobayashi, Kenichi 1,2 Yamamoto, Kazutoshi 3 Kikuyama, Sakae 3 Machida, Takeo 1 Kobayashi, Tetsuya 1; Email Address: kobayasi@h.jniosh.go.jp; Affiliation: 1: Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimookubo, Sakura, Saitama 338-8570, Japan 2: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan 3: Department of Biology, School of Education, Waseda University, 1-104 Totsuka-machi, Shinjuku-ku, Tokyo 169-8050, Japan; Source Info: Oct2009, Vol. 22 Issue 3, p187; Subject Term: HYPOTHYROIDISM; Subject Term: MICE as laboratory animals; Subject Term: SOMATOTROPIN; Subject Term: PITUITARY gland; Subject Term: HYPERTROPHY; Subject Term: HYPERPLASIA; Subject Term: THYROTROPIN; Subject Term: PROLACTIN; Subject Term: THYROXINE; Author-Supplied Keyword: anterior pituitary; Author-Supplied Keyword: grt mouse; Author-Supplied Keyword: lactotrope; Author-Supplied Keyword: somatotrope; Author-Supplied Keyword: thyrotrope; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 1 Color Photograph, 4 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jinshun Zhao
AU - Bowman, Linda
AU - Xingdong Zhang
AU - Vallyathan, Val
AU - Shih-Houng Young
AU - Castranova, Vincent
AU - Min Ding
T1 - Titanium Dioxide (TiO2) Nanoparticles Induce JB6 Cell Apoptosis Through Activation of the Caspase-8/Bid and Mitochondrial Pathways.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2009/10//
VL - 72
IS - 19
M3 - Article
SP - 1141
EP - 1149
SN - 15287394
AB - Titanium dioxide (TiO2), a commercially important material, is used in a wide variety of products. Although TiO2 is generally regarded as nontoxic, the cytotoxicity, pathogenicity, and carcinogenicity of TiO2 nanoparticles have been recently recognized. The present study investigated TiO2 nanoparticle-induced cell apoptosis and molecular mechanisms involved in this process in a mouse epidermal (JB6) cell line. Using the 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay, TiO2 nanoparticles were found to exhibit higher cytotoxicity than fine particles. YO-PRO-1 iodide (YP) staining demonstrated that both TiO2 nanoparticles and fine particles induced cell death through apoptosis. The signaling pathways involved in TiO2 particle-induced apoptosis were investigated. Western-blot analysis showed an activation of caspase-8, Bid, BAX, and caspase-3 and a decrease of Bcl-2 in JB6 cells treated with TiO2 particles. Time-dependent poly(ADP)ribose polymerase (PARP) cleavage induced by TiO2 nanoparticles was observed. TiO2 particles also induced cytochrome c release from mitochondria to cytosol. Further studies demonstrated that TiO2 nanoparticles induced significant changes in mitochondrial membrane permeability, suggesting the involvement of mitochondria in the apoptotic process. In conclusion, evidence indicated that TiO2 nanoparticles exhibit higher cytotoxicity and apoptotic induction compared to fine particles in JB6 cells. Caspase-8/Bid and mitochondrial signaling may play a major role in TiO2 nanoparticle-induced apoptosis involving the intrinsic mitochondrial pathway. Unraveling the complex mechanisms associated with these events may provide further insights into TiO2 nanoparticle-induced pathogenicity and potential to induce carcinogenicity. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TITANIUM dioxide
KW - NANOPARTICLES
KW - CELL membranes
KW - CARCINOGENICITY
KW - CELL lines
KW - MITOCHONDRIAL DNA
KW - APOPTOSIS
KW - CELL death
KW - MITOCHONDRIA
KW - CELL-mediated cytotoxicity
N1 - Accession Number: 44081083; Jinshun Zhao 1 Bowman, Linda 1 Xingdong Zhang 1 Vallyathan, Val 1 Shih-Houng Young 1 Castranova, Vincent 1 Min Ding 1; Email Address: mid5@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.; Source Info: Oct2009, Vol. 72 Issue 19, p1141; Subject Term: TITANIUM dioxide; Subject Term: NANOPARTICLES; Subject Term: CELL membranes; Subject Term: CARCINOGENICITY; Subject Term: CELL lines; Subject Term: MITOCHONDRIAL DNA; Subject Term: APOPTOSIS; Subject Term: CELL death; Subject Term: MITOCHONDRIA; Subject Term: CELL-mediated cytotoxicity; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; Number of Pages: 9p; Illustrations: 2 Color Photographs, 2 Black and White Photographs, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1080/15287390903091764
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44081083&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MARTINEZ, M.
AU - MAHMOOD, I.
AU - HUNTER, R. P.
T1 - Allometric scaling of clearance in dogs.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2009/10//
VL - 32
IS - 5
M3 - Article
SP - 411
EP - 416
PB - Wiley-Blackwell
SN - 01407783
AB - Most drugs indicated for use in dogs are labeled for administration on a mg/kg basis. Such dosing recommendations are grounded on an assumption that total body clearance ( Cl) scales in a manner directly proportional to body weight (i.e. that it scales with an allometric exponent of 1). Despite the critical nature of this assumption (the range of normal canine body weights can go from as small as 2 lbs to almost 200 lbs), the validity of this assumption has not been rigorously challenged. Therefore, this manuscript provides an initial assessment of the potential ramifications of this assumption. This objective was accomplished through the following three sets of analysis: (i) examining the observed vs. predicted Cl values across 10 drugs based upon interspecies scaling; (ii) estimating the difference in area under the concentration vs. time curve values if Cl scaled directly in proportion to body weight vs. in a manner consistent with the allometric exponent estimated in the first data analysis; and (iii) exploring the impact of breed differences in drug metabolism that may further confound the problem of exposure assessment. Based upon this assessment, we conclude that if Cl does not scale directly in proportion to body weight, the actual drug exposure in large or small dogs could differ markedly from those concentrations estimated on the basis of studies conducted in beagle-sized dogs. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSAGE of drugs
KW - VETERINARY medicine -- Research
KW - DOGS -- Health
KW - DRUG metabolism
KW - BODY weight
N1 - Accession Number: 44133153; MARTINEZ, M. 1; Email Address: marilyn.martinez@fda.hhs.gov MAHMOOD, I. 2 HUNTER, R. P. 3; Affiliation: 1: Division of Therapeutic Drugs for Food Animals (HFV-130), Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, Rockville, MD, USA 2: Office of Blood Review & Research, Center for Biologic Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 3: Elanco Animal Health, A Division of Eli Lilly and Company, Greenfield, IN, USA; Source Info: Oct2009, Vol. 32 Issue 5, p411; Subject Term: DOSAGE of drugs; Subject Term: VETERINARY medicine -- Research; Subject Term: DOGS -- Health; Subject Term: DRUG metabolism; Subject Term: BODY weight; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 411110 Live animal merchant wholesalers; NAICS/Industry Codes: 541940 Veterinary Services; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1111/j.1365-2885.2009.01062.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44133153&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - GONZÁLEZ, J. F.
AU - SHAIKH, B.
AU - REIMSCHUESSEL, R.
AU - KANE, A. S.
T1 - In vitro kinetics of hepatic albendazole sulfoxidation in channel catfish ( Ictalurus punctatus), tilapia ( Oreochromis sp.), rainbow trout ( Oncorhynchus mykiss) and induction of EROD activity in ABZ-dosed channel catfish.
JO - Journal of Veterinary Pharmacology & Therapeutics
JF - Journal of Veterinary Pharmacology & Therapeutics
Y1 - 2009/10//
VL - 32
IS - 5
M3 - Article
SP - 429
EP - 435
PB - Wiley-Blackwell
SN - 01407783
AB - Liver microsomes from market-size ( n = 6) rainbow trout, channel catfish and tilapia were used to investigate in vitro biotransformation kinetics of albendazole (ABZ). ABZ was transformed to a single metabolite, ABZ sulfoxide (ABZ-SO). Catfish displayed the highest maximal velocity ( Vmax = 264.0 ± 58.6 pmols ABZ-SO/min/mg protein) followed by tilapia (112.3 ± 8.2) and rainbow trout (73.3 ± 10.3). Vmax in catfish was significantly different ( P < 0.05) from the other two species. Michaelis–Menten constant ( Km) values (μm) varied significantly among the species: rainbow trout (3.9 ± 0.5), tilapia (9.2 ± 1.7) and catfish (22.0 ± 3.2). However, Vmax/ Km ratios showed no difference among the three species, making them equally efficient performing this phase I biotransformation reaction. In a second series of experiments, channel catfish ( n = 6 per treatment) were dosed in vivo with gel-food containing ABZ (10 mg/kg, p.o.). Fish were killed at 24, 48, 72 and 120 h after dosage. Control fish were fed ABZ-free feed. Induction of ethoxyresorufin-o-deethylase activity was significant ( P < 0.05) in all ABZ-dosed treatments as compared with controls. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Veterinary Pharmacology & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RAINBOW trout
KW - BIOTRANSFORMATION (Metabolism)
KW - ONCORHYNCHUS
KW - TILAPIA
KW - ALBENDAZOLE
N1 - Accession Number: 44133158; GONZÁLEZ, J. F. 1; Email Address: jaimefgonzalez@gmail.com SHAIKH, B. 2 REIMSCHUESSEL, R. 2 KANE, A. S. 3; Affiliation: 1: School of Veterinary Medicine & Animal Science Universidad Nacional de Colombia, Bogotá, Colombia 2: Center for Veterinary Medicine & Food Drug Administration (USFDA), Laurel, MD 3: College of Public Health & Health Professions – University of Florida, Gainesville, FL, USA; Source Info: Oct2009, Vol. 32 Issue 5, p429; Subject Term: RAINBOW trout; Subject Term: BIOTRANSFORMATION (Metabolism); Subject Term: ONCORHYNCHUS; Subject Term: TILAPIA; Subject Term: ALBENDAZOLE; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 7p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1365-2885.2009.01056.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44133158&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105230403
T1 - The costs of turnover in nursing homes.
AU - Mukamel DB
AU - Spector WD
AU - Limcangco R
AU - Wang Y
AU - Feng Z
AU - Mor V
AU - Mukamel, Dana B
AU - Spector, William D
AU - Limcangco, Rhona
AU - Wang, Ying
AU - Feng, Zhanlian
AU - Mor, Vincent
Y1 - 2009/10//2009 Oct
N1 - Accession Number: 105230403. Language: English. Entry Date: 20100115. Revision Date: 20161125. Publication Type: journal article; research. Journal Subset: Biomedical; Peer Reviewed; USA. Grant Information: R01 AG027420/AG/NIA NIH HHS/United States. NLM UID: 0230027.
KW - Models, Statistical
KW - Nursing Homes -- Economics
KW - Personnel Turnover -- Economics
KW - California
KW - Cost Savings
KW - Diagnosis-Related Groups
KW - Health Services Research
KW - Human
KW - Regression
KW - Medicaid -- Economics
KW - Medicare -- Economics
KW - Salaries and Fringe Benefits -- Statistics and Numerical Data
KW - United States
SP - 1039
EP - 1045
JO - Medical Care
JF - Medical Care
JA - MED CARE
VL - 47
IS - 10
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Background: Turnover rates in nursing homes have been persistently high for decades, ranging upwards of 100%.Objectives: To estimate the net costs associated with turnover of direct care staff in nursing homes. DATA AND SAMPLE: Nine hundred two nursing homes in California in 2005. Data included Medicaid cost reports, the Minimum Data Set, Medicare enrollment files, Census, and Area Resource File.Research Design: We estimated total cost functions, which included in addition to exogenous outputs and wages, the facility turnover rate. Instrumental variable limited information maximum likelihood techniques were used for estimation to deal with the endogeneity of turnover and costs.Results: The cost functions exhibited the expected behavior, with initially increasing and then decreasing returns to scale. The ordinary least square estimate did not show a significant association between costs and turnover. The instrumental variable estimate of turnover costs was negative and significant (P = 0.039). The marginal cost savings associated with a 10% point increase in turnover for an average facility was $167,063 or 2.9% of annual total costs.Conclusion: The net savings associated with turnover offer an explanation for the persistence of this phenomenon over the last decades, despite the many policy initiatives to reduce it. Future policy efforts need to recognize the complex relationship between turnover and costs.
SN - 0025-7079
AD - Department of Medicine, University of California, Irvine, California, USA
AD - From the *Department of Medicine, University of California, Irvine, California; daggerIrvine Center for Health Policy Research, University of California, Irvine, California; double daggerU.S. Department of Health and Human Services, Agency for Healthcare Research and Quality, Rockville, Maryland; and section signDepartment of Community Health, Alperin Medical School, Brown University, Providence, Rhode Island.
U2 - PMID: 19648834.
DO - 10.1097/MLR.0b013e3181a3cc62
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105230403&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Naum, Marianna
AU - Brown, Eric W.
AU - Mason-Gamer, Roberta J.
T1 - Phylogenetic evidence for extensive horizontaI gene transfer of type Ill secretion system genes among enterobacterial plant pathogens.
JO - Microbiology (13500872)
JF - Microbiology (13500872)
Y1 - 2009/10//
VL - 155
IS - 10
M3 - Article
SP - 3187
EP - 3199
SN - 13500872
AB - The article presents a report which evaluates the phylogenic evidence for the horizontal gene transfer of type III secretion system (T3SS) genes of enterobacterial plant pathogens. It notes the gene sequences of several plant pathogens such as Erwinia, Brennerai, and Dickeye were compared while phylogenies were reconstructed using parsimony and maximum-likelihood algorithms. It cites that multiple gene transfer occurred among plant pathogens and that their T3SS are mostly related to Psuedomonas.
KW - RESEARCH
KW - Phytopathogenic microorganisms
KW - Phylogeny
KW - Genetic transformation
KW - Erwinia
KW - Parsimony (Statistics)
KW - Algorithms
N1 - Accession Number: 45044502; Naum, Marianna 1,2; Email Address: mariannanaum@fdahhs.gov; Brown, Eric W. 2; Mason-Gamer, Roberta J. 1; Affiliations: 1: Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 6061 1, USA; 2: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration (FDA), College Park, MD 20740, USA; Issue Info: Oct2009, Vol. 155 Issue 10, p3187; Thesaurus Term: RESEARCH; Thesaurus Term: Phytopathogenic microorganisms; Subject Term: Phylogeny; Subject Term: Genetic transformation; Subject Term: Erwinia; Subject Term: Parsimony (Statistics); Subject Term: Algorithms; Number of Pages: 13p; Illustrations: 4 Charts; Document Type: Article
L3 - 10.1099/mic.0.029892-0
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Klamt, Fábio
AU - Zdanov, Stéphanie
AU - Levine, Rodney L.
AU - Pariser, Ashley
AU - Yaqin Zhang
AU - Baolin Zhang
AU - Li-Rong Yu
AU - Veenstra, Timothy D.
AU - Shacter, Emily
T1 - Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin.
JO - Nature Cell Biology
JF - Nature Cell Biology
Y1 - 2009/10//
VL - 11
IS - 10
M3 - Article
SP - 1241
EP - 1246
PB - Nature Publishing Group
SN - 14657392
AB - Physiological oxidants that are generated by activated phagocytes comprise the main source of oxidative stress during inflammation. Oxidants such as taurine chloramine (TnCl) and hydrogen peroxide (H2O2) can damage proteins and induce apoptosis, but the role of specific protein oxidation in this process has not been defined. We found that the actin-binding protein cofilin is a key target of oxidation. When oxidation of this single regulatory protein is prevented, oxidant-induced apoptosis is inhibited. Oxidation of cofilin causes it to lose its affinity for actin and to translocate to the mitochondria, where it induces swelling and cytochrome c release by mediating opening of the permeability transition pore (PTP). This occurs independently of Bax activation and requires both oxidation of cofilin Cys residues and dephosphorylation at Ser 3. Knockdown of endogenous cofilin using targeted siRNA inhibits oxidant-induced apoptosis, which is restored by re-expression of wild-type cofilin but not by cofilin containing Cys to Ala mutations. Exposure of cofilin to TnCl results in intramolecular disulphide bonding and oxidation of Met residues to Met sulphoxide, but only Cys oxidation causes cofilin to induce mitochondrial damage. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Cell Biology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - OXIDIZING agents
KW - OXIDATION
KW - PHOTOCHEMICAL oxidants
KW - CELL death
KW - CARRIER proteins
N1 - Accession Number: 44389303; Klamt, Fábio 1,2 Zdanov, Stéphanie 1 Levine, Rodney L. 3 Pariser, Ashley 1 Yaqin Zhang 1 Baolin Zhang 1 Li-Rong Yu 4,5 Veenstra, Timothy D. 5 Shacter, Emily 1; Email Address: emily.shacter@fda.hhs.gov; Affiliation: 1: Laboratory of Biochemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2: Center of Oxidative Stress Research, Department of Biochemistry, ICBS/Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS 90035-003, Brazil 3: Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA 4: Center for Proteomics, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA 5: Laboratory of Proteomics and Analytical Technologies, Advanced Technologies program, SAIC-Frederick Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA; Source Info: Oct2009, Vol. 11 Issue 10, p1241; Subject Term: APOPTOSIS; Subject Term: OXIDIZING agents; Subject Term: OXIDATION; Subject Term: PHOTOCHEMICAL oxidants; Subject Term: CELL death; Subject Term: CARRIER proteins; Number of Pages: 6p; Illustrations: 2 Diagrams, 1 Chart, 10 Graphs; Document Type: Article
L3 - 10.1038/ncb1968
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Guo-Zheng Li
AU - Hao-Hua Meng
AU - Yang, Mary Qu
AU - Yang, Jack Y.
T1 - Combining support vector regression with feature selection for multivariate calibration.
JO - Neural Computing & Applications
JF - Neural Computing & Applications
Y1 - 2009/10//
VL - 18
IS - 7
M3 - Article
SP - 813
EP - 820
PB - Springer Science & Business Media B.V.
SN - 09410643
AB - Multivariate calibration is a classic problem in the analytical chemistry field and frequently solved by partial least squares (PLS) and artificial neural networks (ANNs) in the previous works. The spaciality of multivariate calibration is high dimensionality with small sample. Here, we apply support vector regression (SVR) as well as ANNs, and PLS to the multivariate calibration problem in the determination of the three aromatic amino acids ( phenylalanine, tyrosine and tryptophan) in their mixtures by fluorescence spectroscopy. The results of the leave-one-out method show that SVR performs better than other methods, and appear to be one good method for this task. Furthermore, feature selection is performed for SVR to remove redundant features and a novel algorithm named Prediction RIsk based FEature selection for support vector Regression (PRIFER) is proposed. Results on the above multivariate calibration data set show that PRIFER is a powerful tool for solving the multivariate calibration problems. [ABSTRACT FROM AUTHOR]
AB - Copyright of Neural Computing & Applications is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CALIBRATION
KW - ANALYTICAL chemistry
KW - NEURAL networks (Computer science)
KW - AMINO acids
KW - FLUORESCENCE spectroscopy
KW - ALGORITHMS
KW - SUPPORT vector machines
KW - Artificial neural networks
KW - Feature selection
KW - Multivariate calibration
KW - Partial least square
KW - Support vector regression
N1 - Accession Number: 44206891; Guo-Zheng Li 1; Email Address: drgzli@gmail.com Hao-Hua Meng 2 Yang, Mary Qu 3 Yang, Jack Y. 4; Affiliation: 1: Department of Control Science and Engineering, Tongji University, 201804 Shanghai, China 2: School of Computer Engineering and Science, Shanghai University, 200072 Shanghai, China 3: National Human Genome Research Institute, National Institutes of Health (NIH), US Department of Health and Human Services, Bethesda, MD 20852, USA 4: Harvard Medical School, Harvard University, Cambridge, MA 02140, USA; Source Info: 2009, Vol. 18 Issue 7, p813; Subject Term: CALIBRATION; Subject Term: ANALYTICAL chemistry; Subject Term: NEURAL networks (Computer science); Subject Term: AMINO acids; Subject Term: FLUORESCENCE spectroscopy; Subject Term: ALGORITHMS; Subject Term: SUPPORT vector machines; Author-Supplied Keyword: Artificial neural networks; Author-Supplied Keyword: Feature selection; Author-Supplied Keyword: Multivariate calibration; Author-Supplied Keyword: Partial least square; Author-Supplied Keyword: Support vector regression; Number of Pages: 8p; Illustrations: 6 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s00521-008-0202-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44206891&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei-Ling Chen
T1 - Equivalence-by-Design for Advanced Dosage Forms and Drug Products.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2009/10//
VL - 33
IS - 10
M3 - Article
SP - 104
EP - 110
PB - Advanstar Communications Inc.
SN - 15432521
AB - Industry and regulatory agencies face several challenges in assessing therapeutic equivalence. FDA has been encouraging drug sponsors to use a systematic approach such as quality-by-design principles for pharmaceutical development. In this regard, therapeutic equivalence may be accomplished by matching the test and reference in vivo drug delivery profiles (iDDPs) before drug absorption. Successful design of a therapeutically equivalent test product can ultimately be made with a better understanding of relevant factors that may have potential impact on the iDDPs of the products in comparison. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Technology is the property of Advanstar Communications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - QUALITY of products
KW - DOSAGE of drugs
KW - DRUG design
KW - DRUG development
KW - DRUG delivery systems
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 44572970; Mei-Ling Chen 1; Email Address: meiling.chen@fda.hhs.gov; Affiliations: 1: Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Building 51, Rm. 4108, Silver Spring, MD 20993-0002; Issue Info: Oct2009, Vol. 33 Issue 10, p104; Thesaurus Term: QUALITY of products; Subject Term: DOSAGE of drugs; Subject Term: DRUG design; Subject Term: DRUG development; Subject Term: DRUG delivery systems; Subject: UNITED States ; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 5p; Document Type: Article
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DP - EBSCOhost
DB - buh
ER -
TY - CONF
AU - Yu, Lawrence X.
AU - Lionberger, Robert
AU - Olson, Michael C.
AU - Johnston, Gordon
AU - Buehler, Gary
AU - Winkle, Helen
T1 - Quality by Design for Generic Drugs.
JO - Pharmaceutical Technology
JF - Pharmaceutical Technology
Y1 - 2009/10//
VL - 33
IS - 10
M3 - Proceeding
SP - 122
EP - 127
PB - Advanstar Communications Inc.
SN - 15432521
AB - A two-day workshop brought together regulators from the Office of Generic Drugs at the US Food and Drug Administration and industry representatives from the Generic Pharmaceutical Association to discuss quality-by-design (QbD) concepts. The authors relay the outcome of that workshop, including common understandings of QbD and how to move forward with QbD-based approaches for generic-drug products. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pharmaceutical Technology is the property of Advanstar Communications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONFERENCES & conventions
KW - PHARMACEUTICAL industry
KW - QUALITY of products
KW - WORKSHOPS (Adult education)
KW - SOCIETIES, etc.
KW - DRUG design
KW - GENERIC drugs
KW - UNITED States. Food & Drug Administration. Office of Generic Drugs
KW - UNITED States
N1 - Accession Number: 44572972; Yu, Lawrence X. 1; Email Address: Lawrence.Yu@fda.hhs.gov; Lionberger, Robert 2; Olson, Michael C. 3; Johnston, Gordon; Buehler, Gary; Winkle, Helen; Affiliations: 1: Office of Generic Drugs, US Food and Drug Administration, 7519 Standish Place, Rockville. MD 20855; 2: Office of Pharmaceutical Science, FDA; 3: Generic Pharmaceutical Association; Issue Info: Oct2009, Vol. 33 Issue 10, p122; Thesaurus Term: CONFERENCES & conventions; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: QUALITY of products; Subject Term: WORKSHOPS (Adult education); Subject Term: SOCIETIES, etc.; Subject Term: DRUG design; Subject Term: GENERIC drugs; Subject Term: UNITED States. Food & Drug Administration. Office of Generic Drugs; Subject: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 4p; Document Type: Proceeding
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DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Hong, Seung In
AU - Choi, Won Young
AU - Cho, Seung Yong
AU - Jung, Se H.
AU - Shin, Boo Y.
AU - Park, Hyun Jin
T1 - Mechanical properties and biodegradability of poly-ɛ-caprolactone/soy protein isolate blends compatibilized by coconut oil
JO - Polymer Degradation & Stability
JF - Polymer Degradation & Stability
Y1 - 2009/10//
VL - 94
IS - 10
M3 - Article
SP - 1876
EP - 1881
SN - 01413910
AB - Abstract: This study was performed for the mechanical properties, adhesion properties and biodegradability depending on the coconut oil content based on poly-ɛ-caprolactone (PCL):soy protein isolate (SPI) blends. Coconut oil was capable of forming the PCL:SPI blend. Tensile strength (TS) of the blend decreased and elongation at break (EAB) increased when the concentration of coconut oil increased. Lap shear strength of all samples was observed in the values of the general formulated hot-melt but in particularly, high adhesive strength was shown at 20 mL of coconut oil. The improvement of surface hydrophilicity and biodegradation resulted from the addition of SPI rather than coconut oil. Consequently, coconut oil acted as a plasticizer and compatibilizer although it did not enhance in biodegradation and surface hydrophilicity. [Copyright &y& Elsevier]
AB - Copyright of Polymer Degradation & Stability is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYMERS -- Biodegradation
KW - LACTONES
KW - SOY proteins
KW - MIXTURES
KW - COCONUT oil
KW - POLYMERS -- Mechanical properties
KW - ADHESION
KW - Biodegradability
KW - Coconut oil
KW - Hot-melt adhesive
KW - Poly-ɛ-caprolactone
KW - Soy protein isolate
N1 - Accession Number: 44940954; Hong, Seung In 1 Choi, Won Young 2 Cho, Seung Yong 3 Jung, Se H. 4 Shin, Boo Y. 4 Park, Hyun Jin 1; Email Address: hjpark@korea.ac.kr; Affiliation: 1: College of Life Sciences and Biotechnology, Korea University, 5 ga Anam-dong, Seongbuk-Gu, Seoul 136-701, Republic of Korea 2: Risk Management Division, The Bureau of Risk Management, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122-704, Republic of Korea 3: Institute of Life Sciences and Biotechnology, College of Life Sciences and Biotechnology, Korea University, 5 ga Anam-dong, Seongbuk-Gu, Seoul 136-701, Republic of Korea 4: School of Chemical Engineering and Technology, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, Republic of Korea; Source Info: Oct2009, Vol. 94 Issue 10, p1876; Subject Term: POLYMERS -- Biodegradation; Subject Term: LACTONES; Subject Term: SOY proteins; Subject Term: MIXTURES; Subject Term: COCONUT oil; Subject Term: POLYMERS -- Mechanical properties; Subject Term: ADHESION; Author-Supplied Keyword: Biodegradability; Author-Supplied Keyword: Coconut oil; Author-Supplied Keyword: Hot-melt adhesive; Author-Supplied Keyword: Poly-ɛ-caprolactone; Author-Supplied Keyword: Soy protein isolate; NAICS/Industry Codes: 311224 Soybean and Other Oilseed Processing; NAICS/Industry Codes: 311225 Fats and Oils Refining and Blending; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.polymdegradstab.2009.04.029
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105146597
T1 - Personal accounts: Jack and the clubhouse road to recovery.
AU - Grillo J
AU - Grillo, Jack
Y1 - 2009/10//
N1 - Accession Number: 105146597. Language: English. Entry Date: 20100326. Revision Date: 20170125. Publication Type: journal article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9502838.
KW - Bipolar Disorder -- Rehabilitation
KW - Residential Facilities
KW - Literature
KW - Community Mental Health Services
KW - Male
KW - Massachusetts
SP - 1305
EP - 1306
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 60
IS - 10
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
SN - 1075-2730
AD - Center for Mental Health Services Research, Worcester, Massachusetts, USA
AD - Center for Mental Health Services Research, Worcester, Massachusetts, USA. johnjack.grillo@umassmed.edu
U2 - PMID: 19797368.
DO - 10.1176/ps.2009.60.10.1305
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105146597&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105252002
T1 - Active cigarette smoking, secondhand smoke exposure at work and home, and self-rated health.
AU - Nakata A
AU - Takahashi M
AU - Swanson NG
AU - Ikeda T
AU - Hojou M
Y1 - 2009/10//
N1 - Accession Number: 105252002. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 0376507.
KW - Health Status
KW - Occupational Exposure -- Adverse Effects
KW - Smoking
KW - Passive Smoking -- Adverse Effects
KW - Adolescence
KW - Adult
KW - Aged
KW - Aged, 80 and Over
KW - Cross Sectional Studies
KW - Environmental Exposure -- Adverse Effects
KW - Female
KW - Housing
KW - Human
KW - Logistic Regression
KW - Male
KW - Middle Age
KW - Odds Ratio
KW - Questionnaires
KW - Work -- Statistics and Numerical Data
KW - Young Adult
SP - 650
EP - 656
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 123
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA.
U2 - PMID: 19875139.
DO - 10.1016/j.puhe.2009.09.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105252002&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105252001
T1 - Seasonal variation in self-reported health and health-related behaviour in Dutch adolescents.
AU - Looij-Jansen PM
AU - de Wilde EJ
AU - Mieloo CL
AU - Donker MC
AU - Verhulst FC
Y1 - 2009/10//
N1 - Accession Number: 105252001. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Europe; Peer Reviewed; Public Health; UK & Ireland. Special Interest: Public Health. NLM UID: 0376507.
KW - Adolescent Behavior
KW - Health Behavior
KW - Health Status
KW - Seasons
KW - Adolescence
KW - Adolescent Psychology
KW - Analysis of Variance
KW - Child
KW - Child Behavior
KW - Child Psychology
KW - Female
KW - Surveys
KW - Human
KW - Male
KW - Mental Health
KW - Netherlands
KW - Questionnaires
SP - 686
EP - 688
JO - Public Health (Elsevier)
JF - Public Health (Elsevier)
JA - PUBLIC HEALTH (ELSEVIER)
VL - 123
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0033-3506
AD - Municipal Public Health Service for Rotterdam Area, Rotterdam, the Netherlands; Department of Public Health, Erasmus Medical Centre, Rotterdam, the Netherlands.
U2 - PMID: 19783266.
DO - 10.1016/j.puhe.2009.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105252001&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Muñoz, X.
AU - Cruz, M. J.
AU - Freixa, A.
AU - Guardino, X.
AU - Morell, F.
T1 - Occupational Asthma Caused by Metal Arc Welding of Iron.
JO - Respiration
JF - Respiration
Y1 - 2009/10//
VL - 78
IS - 4
M3 - Article
SP - 455
EP - 459
SN - 00257931
AB - Epidemiological studies have shown that exposure to welding fumes can be a cause of occupational asthma (OA), although the mechanisms implicated are unknown. We describe 3 patients (all men, mean age 42 years) with OA secondary to exposure to welding fumes generated during metal arc welding on iron. The exposure time ranged from 7 to 43 years and the time of the onset of symptoms following the start of exposure was 2–12 years. Patients were diagnosed by specific inhalation challenge (SIC). Environmental levels of Fe, Cd, Cu, Cr, Ni, NO2, NO, CO, and O3 produced during the SIC did not exceed threshold limit values. Samples of induced sputum were obtained before and after the SIC and showed an increase in neutrophils and concentrations of IL-8, TNF-α and TNF-β after the SIC. This study presents the first clinical findings reported in welders with OA, mainly working with iron. Neutrophilic inflammation seems to play a role in this disease. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
AB - Copyright of Respiration is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DISEASES -- Causes & theories of causation
KW - ASTHMA
KW - SHIELDED metal arc welding
KW - NEUTROPHILS
KW - IRON
KW - CLINICAL trials
KW - Asthma
KW - Asthma, low-dose irritant-induced
KW - Induced sputum
KW - Inhalation challenge
KW - Inhalation challenge, specific
KW - low-dose irritant-induced
KW - Neutrophils
KW - Ozone
KW - specific
N1 - Accession Number: 46839612; Muñoz, X. 1,2,3; Email Address: xmunoz@vhebron.net Cruz, M. J. 1,2 Freixa, A. 4 Guardino, X. 4 Morell, F. 1,2; Affiliation: 1: Pulmonology Department, Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain 2: CIBER Enfermedades Respiratorias (Ciberes), Universidad Autónoma de Barcelona, Barcelona, Spain 3: Department of Cell Biology, Physiology and Immunology, Universidad Autónoma de Barcelona, Barcelona, Spain 4: Spanish National Institute for Occupational Safety and Health, Barcelona, Spain; Source Info: 2009, Vol. 78 Issue 4, p455; Subject Term: DISEASES -- Causes & theories of causation; Subject Term: ASTHMA; Subject Term: SHIELDED metal arc welding; Subject Term: NEUTROPHILS; Subject Term: IRON; Subject Term: CLINICAL trials; Author-Supplied Keyword: Asthma; Author-Supplied Keyword: Asthma, low-dose irritant-induced; Author-Supplied Keyword: Induced sputum; Author-Supplied Keyword: Inhalation challenge; Author-Supplied Keyword: Inhalation challenge, specific; Author-Supplied Keyword: low-dose irritant-induced; Author-Supplied Keyword: Neutrophils; Author-Supplied Keyword: Ozone; Author-Supplied Keyword: specific; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 331110 Iron and Steel Mills and Ferroalloy Manufacturing; NAICS/Industry Codes: 416210 Metal service centres; Number of Pages: 5p; Illustrations: 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1159/000235817
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=46839612&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105171387
T1 - Priorities for research and prevention of occupational cancer.
AU - Schulte PA
AU - Schnorr TM
Y1 - 2009/10//2009 Oct-Dec
N1 - Accession Number: 105171387. Language: English. Entry Date: 20100521. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Middle East. Special Interest: Public Health. NLM UID: 0425754.
KW - Research, Medical
KW - Health and Welfare Planning
KW - Neoplasms -- Prevention and Control
KW - Occupational Diseases -- Prevention and Control
KW - Occupational Exposure -- Adverse Effects
KW - Carcinogens
KW - Neoplasms -- Chemically Induced
KW - Occupational Diseases
KW - Occupational Exposure -- Prevention and Control
KW - United States
SP - 287
EP - 290
JO - Reviews on Environmental Health
JF - Reviews on Environmental Health
JA - REV ENVIRON HEALTH
VL - 24
IS - 4
CY - ,
PB - De Gruyter
SN - 0048-7554
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS-C14, Cincinnati, OH 44256, USA.
U2 - PMID: 20384035.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105171387&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - ORGANISCAK, JOHN A.
AU - CECALA, ANDREW B.
T1 - Doing the Math.
JO - Rock Products
JF - Rock Products
Y1 - 2009/10//
VL - 112
IS - 10
M3 - Article
SP - 20
EP - 22
PB - Mining Media Inc.
SN - 00357464
AB - The article discusses the results of a laboratory testing performed by the U.S. National Institute of Occupational Safety and Health to evaluate the significant factors on an enclosed-cab filtration system. The objective of the experiment is to develop a practical mathematical equation for use by mine operators to attain the desired cab performance specifications. Based on the test, an efficient cab filtration system reduces the dust and dirt entering the heating, ventilating and air conditioning (HVAC) system and increases its thermal effectiveness.
KW - INDUSTRIAL research
KW - FILTERS & filtration
KW - MINES & mineral resources
KW - MINE ventilation
KW - EQUATIONS
KW - UNITED States
KW - NATIONAL Institute for Occupational Safety & Health
N1 - Accession Number: 44881712; ORGANISCAK, JOHN A. 1 CECALA, ANDREW B. 1; Affiliation: 1: Senior research engineer, Respiratory Hazards Control Branch, Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health; Source Info: Oct2009, Vol. 112 Issue 10, p20; Subject Term: INDUSTRIAL research; Subject Term: FILTERS & filtration; Subject Term: MINES & mineral resources; Subject Term: MINE ventilation; Subject Term: EQUATIONS; Subject Term: UNITED States; Company/Entity: NATIONAL Institute for Occupational Safety & Health; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 238910 Site Preparation Contractors; Number of Pages: 3p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Schafer, Ken
AU - Francke-Carroll, Sabine
AU - Hutto, David
AU - Neef, Natasha
AU - Silverman, Lee
AU - Vahle, John
AU - Whitney, Katharine
T1 - Regulatory Forum for Toxicologic Pathology: A Two-year Update.
JO - Toxicologic Pathology
JF - Toxicologic Pathology
Y1 - 2009/10//
VL - 37
IS - 6
M3 - Article
SP - 826
EP - 826
SN - 01926233
N1 - Accession Number: 53126447; Schafer, Ken 1; Francke-Carroll, Sabine 2; Hutto, David 3; Neef, Natasha 4; Silverman, Lee 3; Vahle, John 5; Whitney, Katharine 6; Affiliations: 1: Vet Path Services, Inc. Greenfield, Indiana, USA, kschafer@vetpathservicesinc.com; 2: Office for Food Additive Safety, Center for Food Safety and Applied Nutrition, US FDA, College Park, Maryland, USA; 3: Millennium Pharmaceuticals Cambridge, Massachusetts, USA; 4: Pfizer Gorton, Connecticut, USA; 5: Eli Lilly and Co. Indianapolis, Indiana, USA; 6: Abbott Laboratories Abbot Park, Illinoise, USA; Issue Info: Oct2009, Vol. 37 Issue 6, p826; Number of Pages: 1p; Document Type: Article
L3 - 10.1177/0192623309346747
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=53126447&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Xuan Zhang
AU - Paule, Merle G.
AU - Newport, Glenn D.
AU - Xiaoju Zou
AU - Sadovova, Natalya
AU - Berridge, Marc S.
AU - Apana, Scott M.
AU - Hanig, Joseph P.
AU - Slikker Jr., William
AU - Cheng Wang
T1 - A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using 18F-Annexin V.
JO - Toxicological Sciences
JF - Toxicological Sciences
Y1 - 2009/10//
VL - 111
IS - 2
M3 - Article
SP - 355
EP - 361
SN - 10966080
AB - It has been reported that suppression of N-methyl-D-aspartate (NMDA) receptor function by ketamine may trigger apoptosis of neurons when given repeatedly during the brain growth spurt period. Because microPET scans can provide in vivo molecular imaging at sufficient resolution, it has been proposed as a minimally invasive method for detecting apoptosis using the tracer 18F-labeled annexin V. In this study, the effect of ketamine on the metabolism and integrity of the rat brain were evaluated by investigating the uptake and retention of 18F-fluorodeoxyglucose (FDG) and 18F-annexin V using microPET imaging. On postnatal day (PND) 7, rat pups in the experimental group were exposed to six injections of ketamine (20 mg/kg at 2-h intervals) and control rat pups received six injections of saline. On PND 35, 37 MBq (1 mCi) of 18F-FDG or 18F-annexin V was injected into the tail vein of treated and control rats, and static microPET images were obtained over 1 (FDG) and 2 h (annexin V) following the injection. No significant difference was found in 18F-FDG uptake in the regions of interest (ROIs) in the brains of ketamine-treated rats compared with saline-treated controls. The uptake of 18F-annexin V, however, was significantly increased in the ROI of ketamine-treated rats. Additionally, the duration of annexin V tracer washout was prolonged in the ketamine-treated animals. These results demonstrate that microPET imaging is capable of distinguishing differences in retention of 18F-annexin V in different brain regions and suggests that this approach may provide a minimally invasive biomarker of neuronal apoptosis in rats. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Toxicological Sciences is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BIOCHEMICAL markers
KW - KETAMINE
KW - LIPOCORTINS
KW - RATS
KW - NEURONS
KW - apoptosis
KW - ketamine
KW - microPET
N1 - Accession Number: 44558387; Xuan Zhang 1 Paule, Merle G. 1 Newport, Glenn D. 1 Xiaoju Zou 1 Sadovova, Natalya 2 Berridge, Marc S. 3 Apana, Scott M. 3 Hanig, Joseph P. 4 Slikker Jr., William 1 Cheng Wang 1; Email Address: cheng.wang@fda.hhs.gov; Affiliation: 1: Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 2: Toxicologic Pathology Associates, Jefferson, Arkansas 72079 3: 3D Imaging, LLC, Little Rock, Arkansas 72113 4: Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Oct2009, Vol. 111 Issue 2, p355; Subject Term: BIOCHEMICAL markers; Subject Term: KETAMINE; Subject Term: LIPOCORTINS; Subject Term: RATS; Subject Term: NEURONS; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: ketamine; Author-Supplied Keyword: microPET; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 2 Color Photographs, 4 Graphs; Document Type: Article
L3 - 10.1093/toxsci/kfp167
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44558387&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsertsvadze, Alexander
AU - Yazdi, Fatemeh
AU - Fink, Howard A.
AU - MacDonald, Roderick
AU - Wilt, Timothy J.
AU - Bella, Anthony J.
AU - Ansari, Mohammed T.
AU - Garritty, Chantelle
AU - Soares-Weiser, Karla
AU - Daniel, Raymond
AU - Sampson, Margaret
AU - Moher, David
T1 - Oral Sildenafil Citrate (Viagra) for Erectile Dysfunction: A Systematic Review and Meta-analysis of Harms
JO - Urology
JF - Urology
Y1 - 2009/10//
VL - 74
IS - 4
M3 - Article
SP - 831
EP - 836.e8
SN - 00904295
AB - Objectives: To summarize and compare evidence on harms in sildenafil- and placebo-treated men with erectile dysfunction (ED) in a systematic review and meta-analysis. Methods: Randomized placebo-controlled trials (RCTs) were identified using an electronic search in MEDLINE, EMBASE, PsycINFO, SCOPUS, and Cochrane CENTRAL. The rates of any adverse events (AEs), most commonly reported AEs, withdrawals because of adverse events, and serious adverse events were ascertained and compared between sildenafil and placebo groups. The results of men with ED were stratified by clinical condition(s). Statistical heterogeneity was explored. Meta-analyses based on random-effects model were also performed. Results: A total of 49 RCTs were included. Sildenafil-treated men had a higher risk for all-cause AEs (RR = 1.56, 95% CI: 1.38, 1.76), headache, flushing, dyspepsia, and visual disturbances compared with placebo-treated men. The magnitude of excess risk was greater in fixed- than in flexible-dose trials. The rates of serious adverse events and withdrawals because of adverse events did not differ in sildenafil vs placebo groups. A higher dose of sildenafil corresponded to a greater risk of AEs. The increased risk of harms was observed within and across clinically defined specific groups of patients. Conclusions: There was a lack of RCTs reporting long-term (>6 months) harms data. In short-term trials, men with ED randomized to sildenafil had an increased risk of all-cause any AEs, headache, flushing, dyspepsia, and visual disturbances. The exploration of different modes of dose optimization of sildenafil may be warranted. [Copyright &y& Elsevier]
AB - Copyright of Urology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILDENAFIL
KW - IMPOTENCE -- Treatment
KW - ORAL medication
KW - SYSTEMATIC reviews (Medical research)
KW - META-analysis
KW - PLACEBOS (Medicine)
KW - RANDOMIZED controlled trials
KW - DRUGS -- Side effects
N1 - Accession Number: 44469894; Tsertsvadze, Alexander 1; Email Address: atsertsvadze@ohri.ca Yazdi, Fatemeh 1 Fink, Howard A. 2,3 MacDonald, Roderick 3 Wilt, Timothy J. 3 Bella, Anthony J. 4 Ansari, Mohammed T. 1 Garritty, Chantelle 1 Soares-Weiser, Karla 5 Daniel, Raymond 1 Sampson, Margaret 6 Moher, David 1,7,8; Affiliation: 1: Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada 2: Geriatric Research Education and Clinical Center, VA Medical Center, Minneapolis, Minnesota 3: Center for Chronic Disease Outcomes Research, VA Medical Center Minneapolis and the Minnesota Agency for Healthcare Research and Quality Evidence-based Practice Center, Minnesota 4: Division of Urology, Department of Surgery and Department of Neuroscience, University of Ottawa, Ottawa, Ontario, Canada 5: Enhance Reviews, Kfar Saba, Israel 6: Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada 7: Department of Paediatrics, University of Ottawa, Ottawa, Ontario, Canada 8: Department of Epidemiology and Community Medicine, University of Ottawa; Ottawa, Ontario, Canada; Source Info: Oct2009, Vol. 74 Issue 4, p831; Subject Term: SILDENAFIL; Subject Term: IMPOTENCE -- Treatment; Subject Term: ORAL medication; Subject Term: SYSTEMATIC reviews (Medical research); Subject Term: META-analysis; Subject Term: PLACEBOS (Medicine); Subject Term: RANDOMIZED controlled trials; Subject Term: DRUGS -- Side effects; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.urology.2009.04.026
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44469894&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2012-24470-003
AN - 2012-24470-003
AU - Schutt, Russell K.
AU - Hough, Richard L.
AU - Goldfinger, Stephen M.
AU - Lehman, Anthony F.
AU - Shern, David L.
AU - Valencia, Elie
AU - Wood, Patricia A.
T1 - Lessening homelessness among persons with mental illness: A comparison of five randomized treatment trials.
JF - Asian Journal of Psychiatry
JO - Asian Journal of Psychiatry
JA - Asian J Psychiatr
Y1 - 2009/10//
VL - 2
IS - 3
SP - 100
EP - 105
CY - Netherlands
PB - Elsevier Science
SN - 1876-2018
SN - 1876-2026
AD - Schutt, Russell K., University of Massachusetts Boston, Department of Psychiatry, Harvard Medical School, 401 Park Dr., Landmark Center 2E, Boston, MA, US, 02215
N1 - Accession Number: 2012-24470-003. Partial author list: First Author & Affiliation: Schutt, Russell K.; University of Massachusetts Boston, Department of Psychiatry, Harvard Medical School, Boston, MA, US. Release Date: 20130128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Abuse; Homeless Mentally Ill; Mental Disorders. Minor Descriptor: Housing; Treatment. Classification: Psychological Disorders (3210). Population: Human (10); Male (30); Female (40); Inpatient (50). Location: US. Tests & Measures: Structured Clinical Interview for DSM-III-R; Diagnostic Interview Schedule; Colorado Symptom Index; Addiction Severity Index DOI: 10.1037/t00025-000. Methodology: Clinical Trial; Empirical Study; Interview; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Oct, 2009. Publication History: Accepted Date: Jul 19, 2009; First Submitted Date: Dec 26, 2008. Copyright Statement: All rights reserved. Elsevier B.V. 2009.
AB - We evaluate the influence of housing, services, and individual characteristics on housing loss among formerly homeless mentally ill persons who participated in a five-site (4-city) study in the U.S. Housing and service availability were manipulated within randomized experimental designs and substance abuse and other covariates were measured with a common protocol. Findings indicate that housing availability was the primary predictor of subsequent ability to avoid homelessness, while enhanced services reduced the risk of homelessness if housing was also available. Substance abuse increased the risk of housing loss in some conditions in some projects, but specific findings differed between projects and with respect to time spent in shelters and on the streets. We identify implications for research on homeless persons with mental illness that spans different national and local contexts and involves diverse ethnic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - homeless mentally ill persons
KW - mental illness
KW - disease treatment
KW - housing availability
KW - substance abuse
KW - 2009
KW - Drug Abuse
KW - Homeless Mentally Ill
KW - Mental Disorders
KW - Housing
KW - Treatment
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: FM-48096; FM- 48070; FM-48080; FM-48041; FM-48215. Other Details: Research demonstration grants. Recipients: No recipient indicated
U1 - Sponsor: Center for Mental Health Services. Date: from 1992. Recipients: No recipient indicated
DO - 10.1016/j.ajp.2009.07.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2012-24470-003&site=ehost-live&scope=site
UR - Esv1@columbia.edu
UR - alehman@umaryland.edu
UR - Steve007ny@aol.com
UR - rhough@salud.unm.edu
UR - rschutt@bidmc.harvard.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17155-002
AN - 2009-17155-002
AU - ter Bogt, Nancy C. W.
AU - Bemelmans, Wanda J. E.
AU - Beltman, Frank W.
AU - Broer, Jan
AU - Smit, Andries J.
AU - van der Meer, Klaas
T1 - Preventing weight gain: One-year results of a randomized lifestyle intervention.
JF - American Journal of Preventive Medicine
JO - American Journal of Preventive Medicine
JA - Am J Prev Med
Y1 - 2009/10//
VL - 37
IS - 4
SP - 270
EP - 277
CY - Netherlands
PB - Elsevier Science
SN - 0749-3797
SN - 1873-2607
AD - ter Bogt, Nancy C. W., University Medical Center Groningen, Department of General Practice, Sector F, A. Deusinglaan 1, 9713 AV, Groningen, Netherlands
N1 - Accession Number: 2009-17155-002. PMID: 19765497 Partial author list: First Author & Affiliation: ter Bogt, Nancy C. W.; Department of General Practice, University Medical Center Groningen, Groningen, Netherlands. Release Date: 20100322. Correction Date: 20160512. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Intervention; Lifestyle; Prevention; Weight Control. Minor Descriptor: Clinical Trials; Obesity; Overweight; Primary Health Care; Weight Loss. Classification: Health Psychology & Medicine (3360). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study; Treatment Outcome. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2009. Copyright Statement: American Journal of Preventive Medicine. 2009.
AB - Background: Lifestyle interventions targeting prevention of weight gain may have better long-term success than when aimed at weight loss. Limited evidence exists about such an approach in the primary care setting. Design: An RCT was conducted. Setting/participants: Participants were 457 overweight or obese patients (BMI = 25–40 kg/m², mean age 56 years, 52% women) with either hypertension or dyslipidemia, or both, from 11 general practice locations in the Netherlands. Intervention: In the intervention group, four individual visits to a nurse practitioner (NP) and one feedback session by telephone were scheduled for lifestyle counseling with guidance of the NP using a standardized computerized software program. The control group received usual care from their general practitioner (GP). Main outcome measures: Changes in body weight, waist circumference, blood pressure, and blood lipids after 1 year (dropout <10%). Data were collected in 2006 and 2007. Statistical analyses were conducted in 2007 and 2008. Results: There were more weight losers and stabilizers in the NP group than in the general practitioner usual care (GP-UC) group (77% vs 65%; p < 0.05). In men, mean weight losses were 2.3% for the NP group and 0.1% for the GP-UC group (p < 0.05). Significant reductions occurred also in waist circumference but not in blood pressure, blood lipids, and fasting glucose. In women, mean weight losses were in both groups 1.6%. In the NP group, obese people lost more weight (-3.0%) than the non-obese (−1.3%; p < 0.05). Conclusions: Standardized computer-guided counseling by NPs may be an effective strategy to support weight-gain prevention and weight loss in primary care, in the current trial, particularly among men. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - weight gain prevention
KW - lifestyle interventions
KW - randomized controlled trials
KW - weight loss
KW - primary health care
KW - obesity
KW - overweight
KW - 2009
KW - Intervention
KW - Lifestyle
KW - Prevention
KW - Weight Control
KW - Clinical Trials
KW - Obesity
KW - Overweight
KW - Primary Health Care
KW - Weight Loss
KW - 2009
U1 - Sponsor: Netherlands Organisation for Health Research and Development, Netherlands. Grant: 6200.0016. Other Details: GOAL study. Recipients: No recipient indicated
DO - 10.1016/j.amepre.2009.06.011
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17155-002&site=ehost-live&scope=site
UR - n.c.w.ter.bogt@med.umcg.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-22218-005
AN - 2009-22218-005
AU - Vidrine, Jennifer Irvin
AU - Businelle, Michael S.
AU - Cinciripini, Paul
AU - Li, Yisheng
AU - Marcus, Marianne T.
AU - Waters, Andrew J.
AU - Reitzel, Lorraine R.
AU - Wetter, David W.
T1 - Associations of mindfulness with nicotine dependence, withdrawal, and agency.
JF - Substance Abuse
JO - Substance Abuse
JA - Subst Abus
Y1 - 2009/10//
VL - 30
IS - 4
SP - 318
EP - 327
CY - United Kingdom
PB - Taylor & Francis
SN - 0889-7077
SN - 1547-0164
AD - Vidrine, Jennifer Irvin, Department of Health Disparities Research, University of Texas M. D. Anderson Cancer Center, Unit 1440, P.O. Box 301402, Houston, TX, US, 77230-1402
N1 - Accession Number: 2009-22218-005. PMID: 19904667 Partial author list: First Author & Affiliation: Vidrine, Jennifer Irvin; Department of Health Disparities Research, University of Texas M. D. Anderson Cancer Center, Houston, TX, US. Other Publishers: Haworth Press; Plenum Publishing Corp.; Springer. Release Date: 20100301. Correction Date: 20130422. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wetter, David W. Major Descriptor: Drug Dependency; Nicotine Withdrawal; Smoking Cessation; Tobacco Smoking; Mindfulness. Minor Descriptor: Nicotine. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Wisconsin Inventory of Smoking Dependence Motivecs–68; Affective Information Processing Questionnaire; Mindfulness Attention Awareness Scale; Heaviness of Smoking Index DOI: 10.1037/t04726-000; Self-Efficacy Scale; Fagerstrom Test for Nicotine Dependence; Kentucky Inventory of Mindfulness Skills DOI: 10.1037/t11612-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2009. Copyright Statement: Taylor & Francis Group, LLC
AB - Quitting smoking is a major life stressor that results in numerous aversive consequences, including persistently increased level of post-cessation negative affect and relapse. The identification of factors that may enhance behavioral and emotional regulation after quitting may be useful in enhancing quit rates and preventing relapse. One factor broadly linked with behavioral and emotional regulation is mindfulness. This study examined baseline associations of mindfulness with demographic variables, smoking history, dependence, withdrawal severity, and agency among 158 smokers enrolled in a cessation trial. Results indicated that mindfulness was negatively associated with level of nicotine dependence and withdrawal severity, and positively associated with a sense of agency regarding cessation. Moreover, mindfulness remained significantly associated with these measures even after controlling for key demographic variables. Results suggest that low level of mindfulness may be an important predictor of vulnerability to relapse among adult smokers preparing to quit; thus, mindfulness-based interventions may enhance cessation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mindfulness
KW - nicotine dependence
KW - drug withdrawal
KW - smoking cessation
KW - demographic variables
KW - smoking history
KW - cessation trials
KW - 2009
KW - Drug Dependency
KW - Nicotine Withdrawal
KW - Smoking Cessation
KW - Tobacco Smoking
KW - Mindfulness
KW - Nicotine
KW - 2009
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R01DA018875. Recipients: Wetter, David W. (Prin Inv)
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: K01CD000086. Recipients: Vidrine, Jennifer Irvin (Prin Inv)
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: K01DP001120. Recipients: Reitzel, Lorraine R. (Prin Inv)
U1 - Sponsor: National Cancer Institute, US. Grant: R25CA57730. Recipients: No recipient indicated
DO - 10.1080/08897070903252973
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-22218-005&site=ehost-live&scope=site
UR - ORCID: 0000-0002-7165-5720
UR - ORCID: 0000-0001-9847-8544
UR - ORCID: 0000-0002-9038-2238
UR -
UR - jirvinvidrine@mdanderson.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-22218-006
AN - 2009-22218-006
AU - Waters, Andrew J.
AU - Reitzel, Lorraine R.
AU - Cinciripini, Paul
AU - Li, Yisheng
AU - Marcus, Marianne T.
AU - Vidrine, Jennifer Irvin
AU - Wetter, David W.
T1 - Associations between mindfulness and implicit cognition and self-reported affect.
JF - Substance Abuse
JO - Substance Abuse
JA - Subst Abus
Y1 - 2009/10//
VL - 30
IS - 4
SP - 328
EP - 337
CY - United Kingdom
PB - Taylor & Francis
SN - 0889-7077
SN - 1547-0164
AD - Waters, Andrew J., Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, US, 20814
N1 - Accession Number: 2009-22218-006. PMID: 19904668 Partial author list: First Author & Affiliation: Waters, Andrew J.; Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, US. Other Publishers: Haworth Press; Plenum Publishing Corp.; Springer. Release Date: 20100301. Correction Date: 20140217. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Wetter, David W. Major Descriptor: Cognitions; Tobacco Smoking; Mindfulness. Minor Descriptor: Attention; Emotional States; Major Depression; Smoking Cessation. Classification: Substance Abuse & Addiction (3233); Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Positive Affect Scale of the Positive and Negative Affect Scale; Negative Affect Scale of the Positive and Negative Affect Scale; Center for Epidemiologic Studies Depression Scale; Implicit Association Test DOI: 10.1037/t03782-000; Perceived Stress Scale DOI: 10.1037/t02889-000; Kentucky Inventory of Mindfulness Skills DOI: 10.1037/t11612-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 10. Issue Publication Date: Oct, 2009. Copyright Statement: Taylor & Francis Group, LLC
AB - Theory suggests that mindful individuals exhibit enhanced attentional processing (e.g., attentional control) and that they maintain a detached perspective to problematic stimuli. For smokers, smoking and affective stimuli are problematic stimuli when they try to quit. In this cross-sectional study, smokers (n = 158) completed 3 modified Stroop tasks (to assess attentional control), 3 Implicit Association Tests (IATs; to assess detached perspective), and a battery of self-report assessments. Degree of mindfulness was negatively associated (P < .05) with self-reported negative affect, perceived stress, and depressive symptom severity, and positively associated (P < .05) with positive affect. Degree of mindfulness was not associated with the ability to disengage attention from smoking or affective stimuli. On the depression IAT, more mindful participants exhibited a more negative IAT effect, suggesting that they may have developed a detached perspective to depression-related stimuli. Theoretical and clinical implications of the data are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mindfulness
KW - implicit cognition
KW - self–reported affects
KW - attentional processing
KW - depression
KW - smoking
KW - 2009
KW - Cognitions
KW - Tobacco Smoking
KW - Mindfulness
KW - Attention
KW - Emotional States
KW - Major Depression
KW - Smoking Cessation
KW - 2009
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R01 DA018875. Recipients: Wetter, David W.
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: K01 DP00008. Recipients: Vidrine, Jennifer Irvin
U1 - Sponsor: Centers for Disease Control and Prevention. Grant: K01 DP001120. Recipients: Reitzel, Lorraine R.
DO - 10.1080/08897070903252080
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-22218-006&site=ehost-live&scope=site
UR - ORCID: 0000-0001-9847-8544
UR - ORCID: 0000-0002-7165-5720
UR -
UR - andrew.waters@usuhs.mil
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18232-009
AN - 2009-18232-009
AU - Berdahl, Terceira A.
AU - Torres Stone, Rosalie A.
T1 - Examining Latino differences in mental healthcare use: The roles of acculturation and attitudes towards healthcare.
JF - Community Mental Health Journal
JO - Community Mental Health Journal
JA - Community Ment Health J
Y1 - 2009/10//
VL - 45
IS - 5
SP - 393
EP - 403
CY - Germany
PB - Springer
SN - 0010-3853
SN - 1573-2789
AD - Berdahl, Terceira A., Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Suite 5000, Rockville, MD, US, 20850
N1 - Accession Number: 2009-18232-009. PMID: 19690955 Partial author list: First Author & Affiliation: Berdahl, Terceira A.; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, US. Release Date: 20100125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Acculturation; Attitudes; Ethnic Identity; Health Care Utilization; Latinos/Latinas. Minor Descriptor: Health Care Services. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: Cuba; Mexico; Puerto Rico. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Self Administered Questionnaire. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Aug 19, 2009; Accepted Date: Jul 23, 2009; First Submitted Date: Jun 2, 2008. Copyright Statement: Springer Science+Business Media, LLC. 2009.
AB - Latinos are less likely to use mental health services compared to non-Latino whites, but little research has examined the relative contribution of acculturation and attitudes towards healthcare. In the current study, we analyze data from a nationally representative sample of Mexicans, Cubans, Puerto Ricans and non-Latino whites from the 2002–2003 Medical Expenditure Panel Survey (n = 30,234). Findings show different utilization patterns in use of specialty, non-specialty, and any type of mental healthcare across the three Latino subgroups. The predictive efficacy of acculturation variables on ethnic group differences varies by subgroup. Self-reliant attitudes towards healthcare are associated with lower use, but these attitudes do not explain the ethnic gaps in use. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - Latino differences
KW - mental healthcare
KW - acculturation
KW - attitudes
KW - health care service use
KW - 2009
KW - Acculturation
KW - Attitudes
KW - Ethnic Identity
KW - Health Care Utilization
KW - Latinos/Latinas
KW - Health Care Services
KW - 2009
U1 - Sponsor: Agency for Healthcare Research and Quality, US. Recipients: No recipient indicated
DO - 10.1007/s10597-009-9231-6
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18232-009&site=ehost-live&scope=site
UR - rosalie.torresstone@umassmed.edu
UR - terceira.berdahl@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19387-009
AN - 2009-19387-009
AU - Goughler, Donald H.
AU - Anderson, Carol M.
T1 - Structural design for a university–agency research collaboration: Bridging an historical distance.
JF - Families in Society
JO - Families in Society
JA - Fam Soc
Y1 - 2009/10//Oct-Dec, 2009
VL - 90
IS - 4
SP - 419
EP - 424
CY - US
PB - Alliance for Children & Families
SN - 1044-3894
SN - 1945-1350
AD - Goughler, Donald H., Family Services of Western Pennsylvania, 3230 William Pitt Way, Pittsburgh, PA, US, 15238-1361
N1 - Accession Number: 2009-19387-009. Other Journal Title: Social Casework. Partial author list: First Author & Affiliation: Goughler, Donald H.; Family Services of Western Pennsylvania, Pittsburgh, PA, US. Release Date: 20100802. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Collaboration; Colleges; Community Services; Experimenters; Social Services. Minor Descriptor: Experimental Design. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Oct-Dec, 2009. Publication History: Accepted Date: Dec 4, 2008; Revised Date: Nov 26, 2008; First Submitted Date: Sep 26, 2008. Copyright Statement: Alliance for Children and Families. 2009.
AB - Social service agencies need the knowledge that can be gained through research, and universities are equipped to conduct research. It seems like a natural partnership. Yet, university research conducted in agencies often fails to satisfy the interests of either party. In seeking successful frameworks for meaningful applied research in community settings, universities and agencies must form an intentional relationship that integrates the capacities of the differently oriented partners. This article describes a partnership framework in which both community agency staff and university researchers discarded the usual disunified approach to addressing service questions and committed to an embedded, interactive, investigative model in which all participants merged their specific skills to gain mutually fulfilling outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - structural design
KW - university agencies
KW - research collaboration
KW - social service agencies
KW - community agency staff
KW - university researchers
KW - 2009
KW - Collaboration
KW - Colleges
KW - Community Services
KW - Experimenters
KW - Social Services
KW - Experimental Design
KW - 2009
DO - 10.1606/1044-3894.3918
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19387-009&site=ehost-live&scope=site
UR - GoughlerD@fswp.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-16753-007
AN - 2009-16753-007
AU - Hesselink, Arlette E.
AU - Verhoeff, Arnoud P.
AU - Stronks, Karien
T1 - Ethnic health care advisors: A good strategy to improve the access to health care and social welfare services for ethnic minorities?
JF - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JO - Journal of Community Health: The Publication for Health Promotion and Disease Prevention
JA - J Community Health
Y1 - 2009/10//
VL - 34
IS - 5
SP - 419
EP - 429
CY - Germany
PB - Springer
SN - 0094-5145
SN - 1573-3610
AD - Hesselink, Arlette E., Department of Epidemiology and Health Promotion, Public Health Service Amsterdam, P.O. Box 2200, 1000 CE, Amsterdam, Netherlands
N1 - Accession Number: 2009-16753-007. PMID: 19718526 Partial author list: First Author & Affiliation: Hesselink, Arlette E.; Department of Epidemiology and Health Promotion, Public Health Service Amsterdam, Amsterdam, Netherlands. Release Date: 20100208. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Hesselink, Arlette E. Major Descriptor: Community Welfare Services; Health Care Services; Minority Groups; Racial and Ethnic Differences. Classification: Community & Social Services (3373); Culture & Ethnology (2930). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Aug 29, 2009. Copyright Statement: The Author(s). 2009.
AB - Empirical studies indicate that ethnic minorities have limited access to health care and welfare services compared with the host population. To improve this access, ethnic health care (HC) advisors were introduced in four districts in Amsterdam, the Netherlands. HC advisors work for all health care and welfare services and their main task is to provide information on health care and welfare to individuals and groups and refer individuals to services. Action research was carried out over a period of 2 years to find out whether and how this function can contribute to improve access to services for ethnic minorities. Information was gathered by semi-structured interviews, analysing registration forms and reports, and attending meetings. The function’s implementation and characteristics differed per district. The ethnicity of the health care advisors corresponded to the main ethnic groups in the district: Moroccan and Turkish (three districts) and sub-Sahara African and Surinamese (one district). HC advisors reached many ethnic inhabitants (n = 2,224) through individual contacts. Half of them were referred to health care and welfare services. In total, 576 group classes were given. These were mostly attended by Moroccan and Turkish females. Outreach activities and office hours at popular locations appeared to be important characteristics for actually reaching ethnic minorities. Furthermore, direct contact with a well-organized back office seems to be important. HC advisors were able to reach many ethnic minorities, provide information about the health care and welfare system, and refer them to services. Besides adapting the function to the local situation, some general aspects for success can be indicated: the ethnic background of the HC advisor should correspond to the main ethnic minority groups in the district, HC advisors need to conduct outreach work, there must be a well-organized back office to refer clients to, and there needs to be enough commitment among professionals of local health and welfare services. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnic health care advisors
KW - health care services
KW - social welfare services
KW - ethnic minorities
KW - 2009
KW - Community Welfare Services
KW - Health Care Services
KW - Minority Groups
KW - Racial and Ethnic Differences
KW - 2009
U1 - Sponsor: Netherlands Organisation for Health Research and Development, Netherlands. Recipients: Hesselink, Arlette E.; Verhoeff, Arnoud P.; Stronks, Karien
DO - 10.1007/s10900-009-9171-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-16753-007&site=ehost-live&scope=site
UR - ahesselink@ggd.amsterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-13472-006
AN - 2009-13472-006
AU - Delany, Peter J.
AU - Shields, Joseph J.
AU - Roberts, Dana L.
T1 - Program and client characteristics as predictors of the availability of social support services in community-based substance abuse treatment programs.
JF - The Journal of Behavioral Health Services & Research
JO - The Journal of Behavioral Health Services & Research
JA - J Behav Health Serv Res
Y1 - 2009/10//
VL - 36
IS - 4
SP - 450
EP - 464
CY - Germany
PB - Springer
SN - 1094-3412
AD - Delany, Peter J., Office of Applied Studies, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 7-1047, Rockville, MD, US, 20857
N1 - Accession Number: 2009-13472-006. PMID: 19082738 Other Journal Title: Journal of Mental Health Administration. Partial author list: First Author & Affiliation: Delany, Peter J.; Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD, US. Other Publishers: National Council for Community Behavioral Healthcare (NCCBH). Release Date: 20100104. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Client Characteristics; Drug Abuse; Drug Rehabilitation; Social Support. Classification: Drug & Alcohol Rehabilitation (3383). Population: Human (10); Male (30); Female (40); Outpatient (60). Age Group: Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 15. Issue Publication Date: Oct, 2009. Copyright Statement: National Council for Community Behavioral Healthcare. 2008.
AB - Recent emphases on increasing accountability, using less intensive settings, and implementing evidence-based services helped to focus the research community on the structure, processes, and outcomes of services delivered to substance abuse clients. Considerably less attention has been given to understanding how to structure services to enhance engagement and retention leading to treatment continuity. This study examined structural characteristics of community-based treatment facilities in relationship to the availability of supportive services within a sample of 1,332 substance abuse treatment programs surveyed through the Alcohol and Drug Services Study in 1996 and 1997. Structural and client characteristics are important predictors of added supportive services. Furthermore, a program with a broader and established set of core services is more likely to have expanded supportive services. These findings have implications for public health professionals, both in terms of ensuring sustainable service programming for these chronic clients and in identifying services to adopt or discard to meet a population with multiple needs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - program
KW - client characteristics
KW - social support services
KW - community-based substance abuse treatment programs
KW - 2009
KW - Client Characteristics
KW - Drug Abuse
KW - Drug Rehabilitation
KW - Social Support
KW - 2009
DO - 10.1007/s11414-008-9153-z
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13472-006&site=ehost-live&scope=site
UR - dana.roberts@samhsa.hhs.gov
UR - shields@cua.edu
UR - peter.delany@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17799-005
AN - 2009-17799-005
AU - House, Ron
AU - Krajnak, Kristine
AU - Manno, Michael
AU - Lander, Lina
T1 - Current perception threshold and the HAVS Stockholm sensorineural scale.
JF - Occupational Medicine
JO - Occupational Medicine
JA - Occup Med (Lond)
Y1 - 2009/10//
VL - 59
IS - 7
SP - 476
EP - 482
CY - United Kingdom
PB - Oxford University Press
SN - 0962-7480
SN - 1471-8405
AD - House, Ron, Department of Occupational and Environmental Health, St Michael’s Hospital, 30 Bond Street, Toronto, ON, Canada, M5B 1W8
N1 - Accession Number: 2009-17799-005. PMID: 19460876 Partial author list: First Author & Affiliation: House, Ron; Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Release Date: 20100329. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Nervous System Disorders; Occupational Exposure; Psychometrics; Vibration; Work Related Illnesses. Classification: Neuropsychological Assessment (2225); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30). Location: Canada. Age Group: Adulthood (18 yrs & older) (300). Tests & Measures: Hand Arm Vibration Syndrome Stockholm Sensorineural Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: May 21, 2009. Copyright Statement: The Author. 2009.
AB - Background: It is important to determine which tests of sensorineural dysfunction identify the neurological damage from hand–arm vibration exposure. Aims: To examine the association between the hand–arm vibration syndrome (HAVS) Stockholm sensorineural scale stages and tests of peripheral neurological function including measurement of current perception threshold (CPT) and nerve conduction. Methods: All the subjects were men who were assessed for HAVS with a medical and occupational history and physical examination to determine the Stockholm stage, CPT testing at frequencies of 5, 250 and 2,000 Hz for the median and ulnar nerves and measurement of nerve conduction carried out in a blinded fashion. Results: A total of 155 of the 157 recruited subjects agreed to take part in the study, a 99% participation rate. CPT was statistically significantly increased (P < 0.001) in both Stockholm sensorineural Stages 1 and ≥2 in comparison to Stage 0 for every frequency and nerve combination. However, CPT could not discriminate well between Stages 1 and ≥2. There was no association between median or ulnar neuropathy measured by nerve conduction and the Stockholm stages. Polychotomous multinomial logistic regression indicated that the CPT measurements at 2000 Hz, corresponding to damage to large myelinated nerve fibres, were most predictive of both Stockholm Stages 1 and ≥2 in comparison to Stage 0. Conclusions: Neuropathy measured by nerve conduction was unrelated to the Stockholm scale stages. CPT was increased above Stage 0 but did not distinguish well between the higher stages of the Stockholm scale. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - hand arm vibration syndrome Stockholm sensorineural scale
KW - psychometrics
KW - sensorineural dysfunction
KW - peripheral neurological function
KW - hand–arm vibration exposure
KW - 2009
KW - Nervous System Disorders
KW - Occupational Exposure
KW - Psychometrics
KW - Vibration
KW - Work Related Illnesses
KW - 2009
U1 - Sponsor: Research Advisory Council, Workplace Safety and Insurance Board, Canada. Grant: RAC01031; WSIB980074. Recipients: No recipient indicated
DO - 10.1093/occmed/kqp066
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17799-005&site=ehost-live&scope=site
UR - houser@smh.toronto.on.ca
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17555-013
AN - 2009-17555-013
AU - Ujcic-Voortman, Joanne K.
AU - Schram, Miranda T.
AU - Jacobs-van der Bruggen, Monique A.
AU - Verhoeff, Arnoud P.
AU - Baan, Caroline A.
T1 - Diabetes prevalence and risk factors among ethnic minorities.
JF - European Journal of Public Health
JO - European Journal of Public Health
JA - Eur J Public Health
Y1 - 2009/10//
VL - 19
IS - 5
SP - 511
EP - 515
CY - United Kingdom
PB - Oxford University Press
SN - 1101-1262
SN - 1464-360X
AD - Ujcic-Voortman, Joanne K., Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, P.O. Box 2200, 1000 CE, Amsterdam, Netherlands
N1 - Accession Number: 2009-17555-013. PMID: 19587231 Partial author list: First Author & Affiliation: Ujcic-Voortman, Joanne K.; Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, Netherlands. Release Date: 20100208. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Diabetes; Epidemiology; Minority Groups; Risk Factors. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Jul 8, 2009; Accepted Date: Jun 18, 2009; First Submitted Date: Nov 6, 2008. Copyright Statement: All rights reserved. The Author. 2009.
AB - Background: Ethnic minorities living in Western societies may have a higher prevalence of diabetes. We investigated whether the prevalence of diabetes among Turkish and Moroccan migrants differs from the indigenous urban population in the Netherlands, and whether these differences can be explained by differences in risk factors. Methods: In 2004 a general health survey, stratified by ethnicity and age, was carried out among the population of Amsterdam. The current study included 375 Turkish, 314 Moroccan and 417 Dutch individuals aged 18–70 years. Participants underwent a physical examination and a health interview. Diabetes was based on self-report, the use of anti-diabetic medicine, blood glucose levels and HbA1c. Results: The prevalence of diabetes in the Amsterdam population was significantly higher in Turkish (5.6%) and Moroccan (8.0%), compared to Dutch individuals (3.1%). These differences, which were much larger after adjustment for age, were only partly explained by the lower socioeconomic status and higher frequency of obesity among ethnic minorities. The difference between Dutch and Moroccan individuals remained significant even after adjustments for multiple risk factors. The typical age of onset of diabetes in both Turks and Moroccans is respectively one and two decades younger than in the indigenous population. Conclusion: Diabetes is more prevalent among Turkish and Moroccan migrants as compared to the indigenous population. Only part of this difference can be explained by differences in demographic and lifestyle risk factors. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - diabetes
KW - prevalence
KW - risk factors
KW - ethnic minorities
KW - 2009
KW - Diabetes
KW - Epidemiology
KW - Minority Groups
KW - Risk Factors
KW - 2009
DO - 10.1093/eurpub/ckp096
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17555-013&site=ehost-live&scope=site
UR - jujcic@ggd.amsterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-13131-002
AN - 2009-13131-002
AU - Snowden, Lonnie R.
AU - Masland, Mary C.
AU - Fawley, Kya
AU - Wallace, Neal
T1 - Ethnic differences in children’s entry into public mental health care via emergency mental health services.
JF - Journal of Child and Family Studies
JO - Journal of Child and Family Studies
JA - J Child Fam Stud
Y1 - 2009/10//
VL - 18
IS - 5
SP - 512
EP - 519
CY - Germany
PB - Springer
SN - 1062-1024
SN - 1573-2843
AD - Snowden, Lonnie R., School of Social Welfare, University of California Berkeley, 120 Haviland Hall, Berkeley, CA, US, 94720
N1 - Accession Number: 2009-13131-002. PMID: 19730741 Partial author list: First Author & Affiliation: Snowden, Lonnie R.; School of Social Welfare, University of California Berkeley, Berkeley, CA, US. Release Date: 20091005. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: AcademyHealth Annual Research Meeting, Jun, 2007, Orlando, FL, US. Conference Note: The results from this paper were displayed as a poster presentation entitled: "Psychiatric crisis services as entry point into public mental health care for ethnic minority children and youth." The poster was presented at the aforementioned meeting. Additionally, the results for African American children and youth presented in the paper were part of a poster entitled: "Disparities in utilization of crisis services among African American and Caucasian children in California's public mental health system." This poster was presented at the Society for Social Work Research’s annual conference in San Francisco, CA on January 11–14 2007. Major Descriptor: Emergency Services; Mental Health Services; Public Health Services; Racial and Ethnic Differences; Health Disparities. Minor Descriptor: Crises; Foster Care; Mental Health. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Neonatal (birth-1 mo) (120); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Feb 5, 2009. Copyright Statement: This article is published with open access at Springerlink.com. The Author(s). 2009.
AB - For children and youth making a mental health crisis visit, we investigated ethnic disparities in whether the children and youth were currently in treatment or whether this crisis visit was an entry or reentry point into mental health treatment. We gathered Medicaid claims for mental health services provided to 20,110 public-sector clients ages 17 and younger and divided them into foster care and non-foster care subsamples. We then employed logistic regression to analyze our data with sociodemographic and clinical controls. Among children and youth who were not placed in foster care, African Americans, Latinos, and Asian Americans were significantly less likely than Caucasians to have received mental health care during the three months preceding a crisis visit. Disparities among children and youth in foster care were not statistically significant. Ethnic minority children and youth were more likely than Caucasians to use emergency care as an entry or reentry point into the mental health treatment, thereby exhibiting a crisis-oriented pattern of care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ethnic disparities
KW - children
KW - public mental health care
KW - emergency mental health services
KW - foster care
KW - crisis visit
KW - 2009
KW - Emergency Services
KW - Mental Health Services
KW - Public Health Services
KW - Racial and Ethnic Differences
KW - Health Disparities
KW - Crises
KW - Foster Care
KW - Mental Health
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH067871. Recipients: No recipient indicated
DO - 10.1007/s10826-008-9253-7
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13131-002&site=ehost-live&scope=site
UR - kfawley@berkeley.edu
UR - snowden@berkeley.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-05999-004
AN - 2010-05999-004
AU - Nakata, A.
AU - Takahashi, M.
AU - Swanson, N. G.
AU - Ikeda, T.
AU - Hojou, M.
T1 - Active cigarette smoking, secondhand smoke exposure at work and home, and self-rated health.
JF - Public Health
JO - Public Health
JA - Public Health
Y1 - 2009/10//
VL - 123
IS - 10
SP - 650
EP - 656
CY - Netherlands
PB - Elsevier Science
SN - 0033-3506
AD - Nakata, A., National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH, US, 45226
N1 - Accession Number: 2010-05999-004. PMID: 19875139 Partial author list: First Author & Affiliation: Nakata, A.; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, US. Release Date: 20100802. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Home Environment; Passive Smoking; Tobacco Smoking; Working Conditions. Classification: Drug & Alcohol Usage (Legal) (2990); Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: Japan. Age Group: Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Center for Epidemiologic Studies Depression Scale. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Oct 28, 2009; Accepted Date: Sep 11, 2009; Revised Date: Jul 21, 2009; First Submitted Date: Aug 27, 2008.
AB - Objectives: Although active smoking has been reported to be associated with poor self-rated health (SRH), its association with secondhand smoke (SHS) is not well understood. Study design: A cross-sectional study was conducted to examine the association of active smoking and SHS exposure with SRH. Methods: A total of 2558 workers (1899 men and 689 women), aged 16–83 (mean 45) years, in 296 small and medium-sized enterprises were surveyed by means of a self-administered questionnaire. Smoking status and exposure levels to SHS (no, occasional or regular) among lifetime non-smokers were assessed separately at work and at home. SRH was assessed with the question: How would you describe your health during the past 1-year period (very poor, poor, good, very good)? SRH was dichotomized into suboptimal (poor, very poor) and optimal (good, very good). Odds ratios (ORs) with 95% confidence intervals (CIs) for reporting suboptimal vs optimal SRH according to smoking status and smoke exposure were calculated. Results: Current heavy smokers (20+ cigarettes/day) had a significantly increased suboptimal SRH than lifetime non-smokers after adjusting for sociodemographic, lifestyle, physical and occupational factors (OR 1.34, 95% CI 1.06–1.69). Similarly, lifetime non-smokers occasionally exposed to SHS at work alone had worse SRH than their unexposed counterparts (OR 1.50, 95% CI 1.02–2.11). In contrast, lifetime non-smokers exposed at home alone had no significant increase in suboptimal SRH. Conclusions: The present study indicates an increase in suboptimal SRH among current heavy smokers, and suggests that SHS exposure at work is a possible risk factor for non-smokers. Whether or not the association is causal, control of smoking at work may protect workers from developing future health conditions. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - active cigarette smoking
KW - self–rated health
KW - secondhand smoke exposure
KW - work place
KW - home
KW - 2009
KW - Health
KW - Home Environment
KW - Passive Smoking
KW - Tobacco Smoking
KW - Working Conditions
KW - 2009
U1 - Sponsor: Ministry of Education, Culture, Sports, Science and Technology, Japan. Grant: 16659634. Other Details: Grant-in-aid for exploratory research. Recipients: No recipient indicated
DO - 10.1016/j.puhe.2009.09.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-05999-004&site=ehost-live&scope=site
UR - cji5@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-05999-010
AN - 2010-05999-010
AU - van de Looij-Jansen, P. M.
AU - de Wilde, E. J.
AU - Mieloo, C. L.
AU - Donker, M. C. H.
AU - Verhulst, F. C.
T1 - Seasonal variation in self-reported health and health-related behaviour in Dutch adolescents.
JF - Public Health
JO - Public Health
JA - Public Health
Y1 - 2009/10//
VL - 123
IS - 10
SP - 686
EP - 688
CY - Netherlands
PB - Elsevier Science
SN - 0033-3506
AD - van de Looij-Jansen, P. M., Youth Department, Municipal Public Health Service for Rotterdam Area, P.O. Box 70032, 3000 LP, Rotterdam, Netherlands
N1 - Accession Number: 2010-05999-010. PMID: 19783266 Partial author list: First Author & Affiliation: van de Looij-Jansen, P. M.; Municipal Public Health Service for Rotterdam Area, Rotterdam, Netherlands. Release Date: 20100802. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Behavior; Seasonal Variations. Classification: Psychosocial & Personality Development (2840). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Tests & Measures: Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000. Methodology: Empirical Study; Longitudinal Study; Quantitative Study. References Available: Y. Page Count: 3. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Sep 23, 2009; Accepted Date: Jul 30, 2009; Revised Date: May 30, 2009; First Submitted Date: Jul 23, 2008. Copyright Statement: All rights reserved. The Royal Society for Public Health. 2009.
AB - Youth health surveys are often used to collect data on the prevalence of health and health-related behavior. As well as using various methods of data collection and different settings, studies also take place in different seasons. Knowledge of seasonal variation in health and health-related behavior is important for the design of epidemiological studies. The aim of this study was to assess seasonality in health or health-related behavior among adolescents in the Netherlands. Data were obtained from the Youth Health Monitor Rotterdam, a longitudinal youth health surveillance system carried out by the Municipal Public Health Service. The present study used data on first- (mainly 12–13 year olds) and third-grade pupils (mainly 14–15 year olds) from secondary schools. The data of 33,129 pupils were included in the analysis. Results show significant seasonal differences for psychological well-being, self-esteem and for some subscales of the Strengths and Difficulties Questionnaire (SDQ). No significant seasonal differences were found for the SDQ subscales ‘emotional symptoms’ and ‘prosocial behavior', perceived health, fruit and vegetable consumption, and use of marijuana. The strongest effect, but still small, was found for alcohol use, showing the highest consumption in May–June. Since no major seasonal variation in self-reported health was found so it seems unnecessary to spread data collection throughout the year for youth health surveys. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - seasonal variation
KW - health
KW - health behavior
KW - Dutch adolescents
KW - 2009
KW - Health
KW - Health Behavior
KW - Seasonal Variations
KW - 2009
DO - 10.1016/j.puhe.2009.07.015
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-05999-010&site=ehost-live&scope=site
UR - vandelooijp@ggd.rotterdam.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-12715-007
AN - 2009-12715-007
AU - Thomas, Monzy
AU - George, Nysia I.
AU - Patterson, Tucker A.
AU - Bowyer, John F.
T1 - Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature.
JF - Synapse
JO - Synapse
JA - Synapse
Y1 - 2009/10//
VL - 63
IS - 10
SP - 881
EP - 894
CY - US
PB - John Wiley & Sons
SN - 0887-4476
SN - 1098-2396
AD - Bowyer, John F., NCTR, HFT-132, 3900 NCTR Road, Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2009-12715-007. PMID: 19582783 Partial author list: First Author & Affiliation: Thomas, Monzy; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, Jefferson, AR, US. Other Publishers: Wiley-Blackwell Publishing Ltd. Release Date: 20090831. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Amphetamine; Blood Vessels; Cytokines; Gene Expression; Hyperthermia. Minor Descriptor: Blood Brain Barrier; Blood Flow; Genes; Meninges; Parietal Lobe; Rats; Striatum. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 14. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Jul 6, 2009; Accepted Date: Jan 23, 2009; First Submitted Date: Oct 24, 2008. Copyright Statement: Wiley-Liss, Inc. 2009.
AB - An amphetamine (AMPH) regimen that does not produce a prominent blood-brain barrier breakdown was shown to significantly alter the expression of genes regulating vascular tone, immune function, and angiogenesis in vasculature associated with arachnoid and pia membranes of the forebrain. Adult-male Sprague-Dawley rats were given either saline injections during environmentally-induced hyperthermia (EIH) or four doses of AMPH with 2 h between each dose (5, 7.5, 10, and 10 mg/kg d-AMPH, s.c.) that produced hyperthermia. Rats were sacrificed either 3 h or 1 day after dosing, and total RNA and protein was isolated from the meninges, arachnoid and pia membranes, and associated vasculature (MAV) that surround the forebrain. Vip, eNos, Drd1a, and Edn1 (genes regulating vascular tone) were increased by either EIH or AMPH to varying degrees in MAV, indicating that EIH and AMPH produce differential responses to enhance vasodilatation. AMPH, and EIH to a lesser extent, elicited a significant inflammatory response at 3 h as indicated by an increased MAV expression of cytokines Il1b, Il6, Ccl-2, Cxcll, and Cxcl2. Also, genes related to heat shock/stress and disruption of vascular homeostasis such as Icam1 and Hsp72 were also observed. The increased expression of Ctgf and Timp1 and the decreased expression of AktI, Anpep, and Mmp2 and Tek (genes involved in stimulating angiogenesis) from AMPH exposure suggest that angiogenesis was arrested or disrupted in MAV to a greater extent by AMPH compared to EIH. Alterations in vascular-related gene expression in the parietal cortex and striatum after AMPH were less in magnitude than in MAV, indicating less of a disruption of vascular homeostasis in these two regions. Changes in the levels of insulin-like growth factor binding proteins Igfbp1, 2, and 5 in MAV, compared to those in striatum and parietal cortex, imply an interaction between these regions to regulate the levels of insulin-like growth factor after AMPH damage. Thus, the vasculature and meninges surrounding the surface of the forebrain may be an important region in which AMPHs can disrupt vascular homeostasis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - amphetamines
KW - vascular tone
KW - meninges
KW - blood-brain barrier
KW - gene expression
KW - hyperthermia
KW - cytokines
KW - angiogenesis
KW - 2009
KW - Amphetamine
KW - Blood Vessels
KW - Cytokines
KW - Gene Expression
KW - Hyperthermia
KW - Blood Brain Barrier
KW - Blood Flow
KW - Genes
KW - Meninges
KW - Parietal Lobe
KW - Rats
KW - Striatum
KW - 2009
DO - 10.1002/syn.20661
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-12715-007&site=ehost-live&scope=site
UR - iohn.bowyer@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17690-001
AN - 2009-17690-001
AU - Mukamel, Dana B.
AU - Spector, William D.
AU - Limcangco, Rhona
AU - Wang, Ying
AU - Feng, Zhanlian
AU - Mor, Vincent
T1 - The costs of turnover in nursing homes.
JF - Medical Care
JO - Medical Care
JA - Med Care
Y1 - 2009/10//
VL - 47
IS - 10
SP - 1039
EP - 1045
CY - US
PB - Lippincott Williams & Wilkins
SN - 0025-7079
SN - 1537-1948
AD - Mukamel, Dana B., Department of Medicine, University of California, Irvine Center for Health Policy Research, 111 Academy Way, Suite 220, Irvine, CA, US, 92697-5800
N1 - Accession Number: 2009-17690-001. PMID: 19648834 Partial author list: First Author & Affiliation: Mukamel, Dana B.; Department of Medicine, University of California, Irvine, CA, US. Release Date: 20100322. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Costs and Cost Analysis; Employee Turnover; Medical Personnel; Nursing Homes. Classification: Professional Psychological & Health Personnel Issues (3400). Population: Human (10). Location: US. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2009. Copyright Statement: Lippincott Williams & Wilkins. 2009.
AB - Background: Turnover rates in nursing homes have been persistently high for decades, ranging upwards of 100%. Objectives: To estimate the net costs associated with turnover of direct care staff in nursing homes. Data and Sample: Nine hundred two nursing homes in California in 2005. Data included Medicaid cost reports, the Minimum Data Set, Medicare enrollment files, Census, and Area Resource File. Research Design: We estimated total cost functions, which included in addition to exogenous outputs and wages, the facility turnover rate. Instrumental variable limited information maximum likelihood techniques were used for estimation to deal with the endogeneity of turnover and costs. Results: The cost functions exhibited the expected behavior, with initially increasing and then decreasing returns to scale. The ordinary least square estimate did not show a significant association between costs and turnover. The instrumental variable estimate of turnover costs was negative and significant (P = 0.039). The marginal cost savings associated with a 10% point increase in turnover for an average facility was $167,063 or 2.9% of annual total costs. Conclusion: The net savings associated with turnover offer an explanation for the persistence of this phenomenon over the last decades, despite the many policy initiatives to reduce it. Future policy efforts need to recognize the complex relationship between turnover and costs. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - costs
KW - turnover
KW - nursing homes
KW - direct care staff
KW - 2009
KW - Costs and Cost Analysis
KW - Employee Turnover
KW - Medical Personnel
KW - Nursing Homes
KW - 2009
DO - 10.1097/MLR.0b013e3181a3cc62
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17690-001&site=ehost-live&scope=site
UR - dmukamel@uci.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-08462-001
AN - 2009-08462-001
AU - Wassell, James T.
T1 - Workplace violence intervention effectiveness: A systematic literature review.
JF - Safety Science
JO - Safety Science
JA - Saf Sci
Y1 - 2009/10//
VL - 47
IS - 8
SP - 1049
EP - 1055
CY - Netherlands
PB - Elsevier Science
SN - 0925-7535
AD - Wassell, James T., Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Road, M/S 1811, Morgantown, WV, US, 26505
N1 - Accession Number: 2009-08462-001. Other Journal Title: Journal of Occupational Accidents. Partial author list: First Author & Affiliation: Wassell, James T.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, WV, US. Release Date: 20091214. Correction Date: 20151228. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Business; Health Care Services; Organizations; Workplace Violence. Minor Descriptor: Intervention; Retailing. Classification: Industrial & Organizational Psychology (3600). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 7. Issue Publication Date: Oct, 2009. Publication History: Accepted Date: Dec 2, 2008; Revised Date: Nov 25, 2008; First Submitted Date: Aug 22, 2008.
AB - This is a systematic review of literature published since 1992, to determine the effectiveness of interventions in preventing workplace violence and to suggest interventions that need further evaluation research. The health care industry is the topic of 54% of the papers, the retail industry is the topic of 11% of the papers, and the remaining papers address the workplace in general or other situations. This finding drives the organization of this review: the first group of papers discussed in this review evaluates interventions to prevent workplace violence in the retail industry—mostly to prevent robbery and violence to retail workers. Singly or in combination, environmental designs in the retail industry, such as increased lighting to improve visibility and a limited cash-handling policy, can make workers safer, but more research is needed to overcome the barriers to implementation of environmental designs, especially in small businesses. The second group of papers in this review is about interventions to prevent violence to health care workers—mostly training and techniques of dealing with combative patients. Training health care workers to better cope with violent patients and to avoid injury is becoming standard practice, but research is needed to identify specific aspects of training and patient management programs that are most effective. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - workplace violence interventions
KW - health care industry
KW - retail industry
KW - 2009
KW - Business
KW - Health Care Services
KW - Organizations
KW - Workplace Violence
KW - Intervention
KW - Retailing
KW - 2009
DO - 10.1016/j.ssci.2008.12.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-08462-001&site=ehost-live&scope=site
UR - JWassell@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18468-014
AN - 2009-18468-014
AU - Grillo, Jack
T1 - Jack and the clubhouse road to recovery.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/10//
VL - 60
IS - 10
SP - 1305
EP - 1306
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Grillo, Jack
N1 - Accession Number: 2009-18468-014. PMID: 19797368 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Grillo, Jack; Center for Mental Health Services Research, MA, US. Release Date: 20100726. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders; Mental Health; Recovery (Disorders); Treatment. Minor Descriptor: Models. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30). Age Group: Adulthood (18 yrs & older) (300). Page Count: 2. Issue Publication Date: Oct, 2009.
AB - I discovered two transitional employment positions with UMass Medical School in collaboration with the International Center for Clubhouse Development (ICCD) at the Program for Clubhouse Research. I started becoming career oriented in junior high school, when I chose to attend a vocational high school instead of traditional classes. My slow professional advancement and troubling personal issues culminated in a crashing and debilitating mental illness in 1989. The next 20 years were spent in recovery. I discovered clubhouses during this transition. And I recently joined the Central Massachusetts Area Research Monitoring Committee as the consumer representative. This group also includes professionals from Massachusetts Department of Mental Health, doctors from the region, and researchers. We meet quarterly to monitor and coordinate studies up for review or in progress. Clubhouses have been my 'yellow brick road' to recovery. Too many know too little about the clubhouse model, hence this communication to you all. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental illness
KW - recovery
KW - clubhouse model
KW - mental health
KW - 2009
KW - Mental Disorders
KW - Mental Health
KW - Recovery (Disorders)
KW - Treatment
KW - Models
KW - 2009
DO - 10.1176/appi.ps.60.10.1305
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18468-014&site=ehost-live&scope=site
UR - johnjack.grillo@umassmed.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-13328-009
AN - 2009-13328-009
AU - Zuvekas, Samuel H.
AU - Olin, Gary L.
T1 - Validating household reports of health care use in the Medical Expenditure Panel Survey.
JF - Health Services Research
JO - Health Services Research
JA - Health Serv Res
Y1 - 2009/10//
VL - 44
IS - 5, Pt1
SP - 1679
EP - 1700
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0017-9124
SN - 1475-6773
AD - Zuvekas, Samuel H., Center for Financing, Access, and Cost Trends (CFACT), Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Rockville, MD, US, 20850
N1 - Accession Number: 2009-13328-009. Partial author list: First Author & Affiliation: Zuvekas, Samuel H.; Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality (AHRQ), Rockville, MD, US. Other Publishers: Blackwell Publishing. Release Date: 20100322. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Costs; Health Care Utilization; Household Management; Surveys. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Appendixes Internet. References Available: Y. Page Count: 22. Issue Publication Date: Oct, 2009. Copyright Statement: Health Research and Educational Trust
AB - Background: The Medical Expenditure Panel Survey (MEPS) is a widely used nationally representative survey of health care use and expenditures. Numerous studies raise concerns that use is underreported in household surveys. Objective: To assess the quality of household reports in the MEPS and the impact of misreporting on descriptive and behavioral analyses. Research Design: Participants in MEPS with Medicare coverage during 2001–2003 were matched to their Medicare enrollment and claims data (4,045 person-year observations). Household reports of Medicare-covered services for the matched sample were validated against Medicare claims. Standard models of the determinants of health care utilization were estimated with both MEPS and claims-based utilization measures. Measures: In-person interviews with household informants obtained data on hospital inpatient, emergency department (ED), and office-based visits. Comparable measures were created from the claims. Results: In the validation sample, households accurately reported inpatient stays (agreement rate = 0.96, κ = 0.89) and number of nights (Lin's concordance statistic = 0.88). Households underreported ED visits by one-third (Lin's concordance statistic = 0.51) and office visits by 19 percent (Lin's concordance statistic = 0.67). Conclusions: Household respondents in the validation sample accurately report inpatient hospitalizations but underreport ED and office visits. Behavioral analyses are largely unaffected because underreporting cuts across all sociodemographic groups. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - household reports
KW - health care usage
KW - Medical Expenditure Panel Survey
KW - health care expenditures
KW - 2009
KW - Health Care Costs
KW - Health Care Utilization
KW - Household Management
KW - Surveys
KW - 2009
DO - 10.1111/j.1475-6773.2009.00995.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-13328-009&site=ehost-live&scope=site
UR - samuel.zuvekas@ahrq.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17548-010
AN - 2009-17548-010
AU - Burneo, Jorge G.
AU - Jette, Nathalie
AU - Theodore, William
AU - Begley, Charles
AU - Parko, Karen
AU - Thurman, David J.
AU - Wiebe, Samuel
T1 - Disparities in epilepsy: Report of a systematic review by the North American Commission of the International League Against Epilepsy.
JF - Epilepsia
JO - Epilepsia
JA - Epilepsia
Y1 - 2009/10//
VL - 50
IS - 10
SP - 2285
EP - 2295
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0013-9580
SN - 1528-1167
AD - Burneo, Jorge G., Epilepsy Programme, University of Western Ontario, 339 Windermere Rd, London, ON, Canada, N6A5A5
N1 - Accession Number: 2009-17548-010. PMID: 19732134 Partial author list: First Author & Affiliation: Burneo, Jorge G.; Epilepsy Programme, University of Western Ontario, London, ON, Canada. Institutional Authors: North American Commission of the International League Against Epilepsy. Other Publishers: Blackwell Publishing; Elsevier; George Banta Publishing Co.; Graphic Press; J.A. Barth Verlag; Lippincott Williams & Wilkins; Lippincott-Raven Publishers; Munksgaard; Raven Press; Scheltema and Holkema. Release Date: 20100322. Correction Date: 20130429. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Epilepsy; Health Disparities. Minor Descriptor: Age Differences; Educational Attainment Level; Racial and Ethnic Differences; Socioeconomic Status. Classification: Medical Treatment of Physical Illness (3363). Population: Human (10). Methodology: Literature Review; Systematic Review. References Available: Y. Page Count: 11. Issue Publication Date: Oct, 2009. Publication History: First Posted Date: Sep 3, 2009; Accepted Date: Jul 6, 2009. Copyright Statement: International League Against Epilepsy. 2009.
AB - Purpose: We undertook a systematic review of the evidence on disparities in epilepsy with a focus on North American data (Canada, United States, and the English-speaking Caribbean). Methods: We identified and evaluated: access to and outcomes following medical and surgical treatment, disability, incidence and prevalence, and knowledge and attitudes. An exhaustive search (1965–2007) was done, including: (1) disparities by socioeconomic status (SES), race/ethnicity, age, or education of subgroups of the epilepsy population; or (2) disparities between people with epilepsy (PWE) and healthy people or with other chronic illnesses. Results: From 1,455 citations, 278 eligible abstracts were identified and 44 articles were reviewed. Comparative research data were scarce in all areas. PWE have been shown to have lower education and employment status; among PWE, differences in access to surgery have been shown by racial/ethnic groups. Aboriginals, women, and children have been shown to differ in use of health resources. Poor compliance has been shown to be associated with lower SES, insufficient insurance, poor relationship with treating clinicians, and not having regular responsibilities. Discussion: Comprehensive, comparative research on all aspects of disparities in epilepsy is needed to understand the causes of disparities and the development of any policies aimed at addressing health disparities and minimizing their impact. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - epilepsy
KW - disparities
KW - socioeconomic status
KW - racial and ethnic differences
KW - age differences
KW - educational level differences
KW - 2009
KW - Epilepsy
KW - Health Disparities
KW - Age Differences
KW - Educational Attainment Level
KW - Racial and Ethnic Differences
KW - Socioeconomic Status
KW - 2009
DO - 10.1111/j.1528-1167.2009.02282.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17548-010&site=ehost-live&scope=site
UR - jburneo2@uwo.ca
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-18608-001
AN - 2009-18608-001
AU - Steege, Andrea L.
AU - Baron, Sherry
AU - Davis, Shelley
AU - Torres-Kilgore, Judith
AU - Sweeney, Marie Haring
T1 - Pandemic influenza and farmworkers: The effects of employment, social, and economic factors.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/10/01/
VL - 99
IS - Suppl 2
SP - S308
EP - S315
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Steege, Andrea L., NIOSH/CDC, 4676 Columbia Pkwy MS R18, Cincinnati, OH, US, 45226
N1 - Accession Number: 2009-18608-001. PMID: 19797742 Partial author list: First Author & Affiliation: Steege, Andrea L.; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, US. Release Date: 20100329. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Agricultural Workers; Employment Status; Influenza; Pandemics; Sociocultural Factors. Minor Descriptor: Economics. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10). References Available: Y. Page Count: 8. Issue Publication Date: Oct 1, 2009. Publication History: Accepted Date: May 2, 2009.
AB - Employment, social, and economic factors have the potential to affect the magnitude of an influenza pandemic among farmworkers. Prevention efforts targeted toward livestock farmworkers, including increased access to seasonal influenza vaccine, risk reduction training, various forms of personal protection, and workplace sanitation, are needed. Crop and livestock farmworkers are at increased risk of exposure to influenza A viruses because of limited resources, substandard housing, immigration status, communication and cultural barriers, and discrimination. Recommendations were gathered from migrant clinicians, farmworker advocates, state and federal government agencies, industry stakeholders, and researchers to overcome these barriers, including surveillance of livestock farmworkers, inclusion of farmworker service organizations in planning efforts, and separation of immigration enforcement from emergency assistance. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - pandemic influenza
KW - farmworkers
KW - economic & social & employment factors
KW - 2009
KW - Agricultural Workers
KW - Employment Status
KW - Influenza
KW - Pandemics
KW - Sociocultural Factors
KW - Economics
KW - 2009
DO - 10.2105/AJPH.2009.161091
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18608-001&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0001-5665-2559
UR - asteege@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105290397
T1 - Pandemic influenza preparedness and vulnerable populations in tribal communities.
AU - Groom AV
AU - Jim C
AU - LaRoque M
AU - Mason C
AU - McLaughlin J
AU - Neel L
AU - Powell T
AU - Weiser T
AU - Bryan RT
Y1 - 2009/10/02/Oct2009 Supplement
N1 - Accession Number: 105290397. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Oct2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Disease Outbreaks -- Prevention and Control
KW - Eskimos
KW - Influenza, Human -- Ethnology
KW - Native Americans
KW - Special Populations
KW - Aged
KW - Chronic Disease
KW - Epidemiology
KW - Health Services Accessibility
KW - Health Services, Indigenous
KW - Influenza -- Trends
KW - Influenza, Human -- Mortality
KW - Models, Theoretical
KW - Prevalence
KW - Strategic Planning
KW - United States
SP - S271
EP - 8
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S2
CY - Washington, District of Columbia
PB - American Public Health Association
AB - American Indian and Alaska Native (AIAN) governments are sovereign entities with inherent authority to establish and administer public health programs within their communities and will be critical partners in national efforts to prepare for pandemic influenza. Within AIAN communities, some subpopulations will be particularly vulnerable during an influenza pandemic because of their underlying health conditions, whereas others will be at increased risk because of limited access to prevention or treatment interventions.We outline potential issues to consider in identifying and providing appropriate services for selected vulnerable populations within tribal communities. We also highlight pandemic influenza preparedness resources available to tribal leaders and their partners in state and local health departments, academia, community-based organizations, and the private sector.
SN - 0090-0036
AD - Immunization Services Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Amy.Groom@ihs.gov
U2 - PMID: 19461107.
DO - 10.2105/ AJPH.2008.157453
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290397&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290398
T1 - Protecting home health care workers: a challenge to pandemic influenza preparedness planning.
AU - Baron S
AU - McPhaul K
AU - Phillips S
AU - Gershon R
AU - Lipscomb J
Y1 - 2009/10/02/Oct2009 Supplement
N1 - Accession Number: 105290398. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Oct2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Disaster Planning
KW - Disease Outbreaks -- Prevention and Control
KW - Home Health Aides
KW - Influenza, Human -- Prevention and Control
KW - Special Populations
KW - Communication
KW - Economics
KW - Education
KW - Epidemiology
KW - Ethics
KW - Female
KW - Health Services Accessibility
KW - Influenza -- Prevention and Control
KW - Legal Procedure
KW - Male
KW - Models, Theoretical
KW - United States
SP - S301
EP - 7
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S2
CY - Washington, District of Columbia
PB - American Public Health Association
AB - The home health care sector is a critical element in a pandemic influenza emergency response. Roughly 85% of the 1.5 million workers delivering in-home care to 7.6 million clients are low-wage paraprofessionals, mostly women, and disproportionately members of racial and ethnic minorities. Home health care workers' ability and willingness to respond during a pandemic depends on appropriate communication, training, and adequate protections, including influenza vaccination and respiratory protection. Preparedness planning should also include support for child care and transportation and help home health care workers protect their income and access to health care. We summarize findings from a national stakeholder meeting, which highlighted the need to integrate home health care employers, workers, community advocates, and labor unions into the planning process.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. SBaron@cdc.gov
U2 - PMID: 19461108.
DO - 10. 2105/AJPH.2008.157339
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290398&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290412
T1 - Pandemic influenza and farmworkers: the effects of employment, social, and economic factors.
AU - Steege AL
AU - Baron S
AU - Davis S
AU - Torres-Kilgore J
AU - Sweeney MH
Y1 - 2009/10/02/Oct2009 Supplement
N1 - Accession Number: 105290412. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Supplement Title: Oct2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Agriculture
KW - Disease Outbreaks -- Prevention and Control
KW - Employment
KW - Farmworkers
KW - Influenza, Avian
KW - Influenza, Human -- Prevention and Control
KW - Socioeconomic Factors
KW - Animals
KW - Communication
KW - Community Health Centers
KW - Culture
KW - Diffusion of Innovation
KW - Discrimination
KW - Emigration and Immigration
KW - Epidemiology
KW - Health Services Accessibility -- Economics
KW - Language
KW - Literacy
KW - Medically Underserved Area
KW - Poultry
KW - Professional-Patient Relations
KW - Program Implementation
KW - Special Populations
KW - Transients and Migrants
KW - Trust
KW - United States
SP - S308
EP - 15
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S2
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Employment, social, and economic factors have the potential to affect the magnitude of an influenza pandemic among farmworkers. Prevention efforts targeted toward livestock farmworkers, including increased access to seasonal influenza vaccine, risk reduction training, various forms of personal protection, and workplace sanitation, are needed. Crop and livestock farmworkers are at increased risk of exposure to influenza A viruses because of limited resources, substandard housing, immigration status, communication and cultural barriers, and discrimination. Recommendations were gathered from migrant clinicians, farmworker advocates, state and federal government agencies, industry stakeholders, and researchers to overcome these barriers, including surveillance of livestock farmworkers, inclusion of farmworker service organizations in planning efforts, and separation of immigration enforcement from emergency assistance.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. asteege@cdc.gov
U2 - PMID: 19797742.
DO - 10.2105/ AJPH.2009.161091
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290412&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105235545
T1 - Opening keynote remarks to the first breastfeeding summit.
AU - Galson S
Y1 - 2009/10/02/2009 Oct Suppl 1
N1 - Accession Number: 105235545. Language: English. Entry Date: 20100129. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2009 Oct Suppl 1. Journal Subset: Biomedical; USA. Special Interest: Obstetric Care. NLM UID: 101260777.
KW - Breast Feeding
KW - Health Policy
KW - Health Promotion -- Administration
KW - Preventive Health Care
KW - Infant
KW - Infant Nutritional Physiology
KW - Infant, Newborn
SP - S5
EP - 7
JO - Breastfeeding Medicine
JF - Breastfeeding Medicine
JA - BREASTFEED MED
VL - 4
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1556-8253
AD - U.S. Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201, USA. tomas.bonome@hhs.gov
U2 - PMID: 19827924.
DO - 10.1089/bfm.2009.0040
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105235545&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105235536
T1 - Breastfeeding and health outcomes.
AU - Meyers D
Y1 - 2009/10/02/2009 Oct Suppl 1
N1 - Accession Number: 105235536. Language: English. Entry Date: 20100129. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2009 Oct Suppl 1. Journal Subset: Biomedical; USA. Special Interest: Obstetric Care. NLM UID: 101260777.
KW - Breast Feeding
KW - Child Development
KW - Infant Nutritional Physiology -- Physiology
KW - Public Health
KW - Medical Practice, Evidence-Based
KW - Infant
KW - Infant, Newborn
KW - Maternal Welfare
KW - Preventive Health Care
SP - S13
EP - 5
JO - Breastfeeding Medicine
JF - Breastfeeding Medicine
JA - BREASTFEED MED
VL - 4
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
SN - 1556-8253
AD - Center for Primary Care, Agency for Healthcare Research and Quality/NIH, 540 Gaither Road, Rockville, MD 20850, USA. david.meyers@ahrq.hhs.gov
U2 - PMID: 19827918.
DO - 10.1089/bfm.2009.0066
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105235536&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Pogribny, Igor P.
AU - Shpyleva, Svitlana I.
AU - Muskhelishvili, Levan
AU - Bagnyukova, Tetyana V.
AU - Jill James, S.
AU - Beland, Frederick A.
T1 - Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet
JO - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
JF - Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
Y1 - 2009/10/02/
VL - 669
IS - 1/2
M3 - Article
SP - 56
EP - 62
SN - 00275107
AB - Abstract: Currently, cancer is recognized as a disease provoked by both genetic and epigenetic events. However, the significance of early genetic and epigenetic alterations with respect to carcinogenic process in general and to liver carcinogenesis in particular remains unexplored. A lack of knowledge regarding how specific alterations during early preneoplasia may be mechanistically related to tumor formation creates a major gap in understanding the role of these genetic and epigenetic abnormalities in carcinogenesis. In the present study we investigated the contribution of DNA damage and epigenetic alterations to liver carcinogenesis induced by a methyl-deficient diet. Feeding Fisher 344 rats a methyl-deficient diet for 9 weeks resulted in DNA damage and aberrant DNA methylation. This was evidenced by an early up-regulation of the base excision DNA repair genes, accumulation of 8-oxodeoxyguanosine and 3′OH-end strand breaks in DNA, pronounced global loss of DNA methylation, and hypermethylation of CpG islands in the livers of methyl-deficient rats. These abnormalities were completely restored in the livers of rats exposed to methyl-deficiency for 9 weeks after removal of the methyl-deficient diet and re-feeding a methyl-sufficient diet. However, when rats were fed a methyl-deficient diet for 18 week and then given a methyl-sufficient diet, only DNA lesions were repaired. The methyl-sufficient diet failed to restore completely the altered DNA methylation status and prevent the progression of liver carcinogenesis. These results suggest that stable alterations in DNA methylation are a factor that promotes the progression of liver carcinogenesis. Additionally, the results indicate that epigenetic changes may be more reliable markers than DNA lesions of the carcinogenic process and carcinogen exposure. [Copyright &y& Elsevier]
AB - Copyright of Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DNA damage
KW - GENETIC toxicology
KW - METHYLATION
KW - CANCER -- Nutritional aspects
KW - CHROMOSOME abnormalities
KW - DNA repair
KW - CARCINOGENESIS -- Animal models
KW - RATS as laboratory animals
KW - DNA methylation
KW - Liver carcinogenesis
KW - Methyl-deficiency
KW - Oxidative DNA damage
N1 - Accession Number: 44406803; Pogribny, Igor P. 1; Email Address: igor.pogribny@fda.hhs.gov Shpyleva, Svitlana I. 1,2 Muskhelishvili, Levan 3 Bagnyukova, Tetyana V. 1 Jill James, S. 4 Beland, Frederick A. 1; Affiliation: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA 2: Department of Mechanisms of Anticancer Therapy, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Kyiv 03022, Ukraine 3: Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA 4: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Source Info: Oct2009, Vol. 669 Issue 1/2, p56; Subject Term: DNA damage; Subject Term: GENETIC toxicology; Subject Term: METHYLATION; Subject Term: CANCER -- Nutritional aspects; Subject Term: CHROMOSOME abnormalities; Subject Term: DNA repair; Subject Term: CARCINOGENESIS -- Animal models; Subject Term: RATS as laboratory animals; Author-Supplied Keyword: DNA methylation; Author-Supplied Keyword: Liver carcinogenesis; Author-Supplied Keyword: Methyl-deficiency; Author-Supplied Keyword: Oxidative DNA damage; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.mrfmmm.2009.05.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44406803&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2014-15908-009
AN - 2014-15908-009
AU - Maheshwari, Manjula
AU - Shi, Jiajun
AU - Badner, Judith A.
AU - Skol, Andrew
AU - Willour, Virginia L.
AU - Muzny, Donna M.
AU - Wheeler, David A.
AU - Gerald, Fowler R.
AU - Detera‐Wadleigh, Sevilla
AU - McMahon, Francis J.
AU - Potash, James B.
AU - Gershon, Elliot S.
AU - Liu, Chunyu
AU - Gibbs, Richard A.
T1 - Common and rare variants of DAOA in bipolar disorder.
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JA - Am J Med Genet B Neuropsychiatr Genet
Y1 - 2009/10/05/
VL - 150B
IS - 7
SP - 960
EP - 966
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1552-4841
SN - 1552-485X
AD - Liu, Chunyu, Department of Psychiatry, University of Chicago, Knapp Center, 924 East 57th Street, R012, Chicago, IL, US, 60637
N1 - Accession Number: 2014-15908-009. PMID: 19194963 Partial author list: First Author & Affiliation: Maheshwari, Manjula; Human Genome Sequencing Center, Department of Molecular, Baylor College of Medicine, Houston, TX, US. Release Date: 20160808. Correction Date: 20160811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Gershon, Elliot S. Major Descriptor: Bipolar Disorder; Polymorphism. Minor Descriptor: Amino Acids; Nucleotides; Oxidases. Classification: Affective Disorders (3211). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. Supplemental Data: Tables and Figures Internet. References Available: Y. Page Count: 7. Issue Publication Date: Oct 5, 2009. Publication History: First Posted Date: Feb 4, 2009; Accepted Date: Dec 10, 2008; First Submitted Date: Sep 13, 2008. Copyright Statement: Wiley‐Liss, Inc. 2009.
AB - The D‐amino acid oxidase activator (DAOA, previously known as G72) gene, mapped on 13q33, has been reported to be genetically associated with bipolar disorder (BP) in several populations. The consistency of associated variants is unclear and rare variants in exons of the DAOA gene have not been investigated in psychiatric diseases. We employed a conditional linkage method—STatistical Explanation for Positional Cloning (STEPC) to evaluate whether any associated single nucleotide polymorphisms (SNPs) account for the evidence of linkage in a pedigree series that previously has been linked to marker D13S779 at 13q33. We also performed an association study in a sample of 376 Caucasian BP parent‐proband trios by genotyping 38 common SNPs in the gene region. Besides, we resequenced coding regions and flanking intronic sequences of DAOA in 555 Caucasian unrelated BP patients and 564 mentally healthy controls, to identify putative functional rare variants that may contribute to disease. One SNP rs1935058 could 'explain' the linkage signal in the family sample set (P = 0.055) using STEPC analysis. No significant allelic association was detected in an association study by genotyping 38 common SNPs in 376 Caucasian BP trios. Resequencing identified 53 SNPs, of which 46 were novel SNPs. There was no significant excess of rare variants in cases relative to controls. Our results suggest that DAOA does not have a major effect on BP susceptibility. However, DAOA may contribute to bipolar susceptibility in some specific families as evidenced by the STEPC analysis. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - DAOA
KW - G72
KW - bipolar disorder
KW - genetic association
KW - resequencing
KW - single nucleotide polymorphism
KW - 2009
KW - Bipolar Disorder
KW - Polymorphism
KW - Amino Acids
KW - Nucleotides
KW - Oxidases
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01MH061613. Recipients: Gershon, Elliot S.
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH042243. Recipients: Potash, James B.
U1 - Sponsor: National Institute of Mental Health, US. Grant: 1R21MH083521. Recipients: No recipient indicated
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Other Details: Young Investigator Awards. Recipients: Shi, Jiajun
U1 - Sponsor: University of Chicago, Brain Research Foundation, US. Recipients: Liu, Chunyu
U1 - Sponsor: Geraldi Norton Foundation. Recipients: No recipient indicated
U1 - Sponsor: Eklund Family. Recipients: No recipient indicated
DO - 10.1002/ajmg.b.30925
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-15908-009&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - cliu@yoda.bsd.uchicago.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2014-15908-011
AN - 2014-15908-011
AU - Grover, Deepak
AU - Verma, Ranjana
AU - Goes, Fernando S.
AU - Mahon, Pamela L. Belmonte
AU - Gershon, Elliot S.
AU - McMahon, Francis J.
AU - Potash, James B.
T1 - Family‐based association of YWHAH in psychotic bipolar disorder.
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JA - Am J Med Genet B Neuropsychiatr Genet
Y1 - 2009/10/05/
VL - 150B
IS - 7
SP - 977
EP - 983
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 1552-4841
SN - 1552-485X
AD - Potash, James B., Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Meyer 4-119, 600 N. Wolfe St., Baltimore, MD, US, 21287
N1 - Accession Number: 2014-15908-011. PMID: 19160447 Partial author list: First Author & Affiliation: Grover, Deepak; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, US. Institutional Authors: NIMH Genetics Initiative Bipolar Disorder Collaborative, Bipolar Disorder Phenome Group. Release Date: 20160808. Correction Date: 20160811. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Potash, James B. Major Descriptor: Bipolar Disorder; Genetic Linkage; Schizophrenia. Minor Descriptor: Nuclear Family; Psychosis. Classification: Psychological Disorders (3210). Population: Human (10). Location: US. Tests & Measures: Schedule for Affective Disorders and Schizophrenia-Lifetime Version; Research Diagnostic Criteria DOI: 10.1037/t04137-000. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Oct 5, 2009. Publication History: First Posted Date: Jan 21, 2009; Accepted Date: Dec 9, 2008; First Submitted Date: Aug 15, 2008. Copyright Statement: Wiley‐Liss, Inc. 2009.
AB - YWHAH is a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP). This gene has been previously shown to be associated with both disorders, and the chromosome location (22q12.3) has been repeatedly implicated in linkage studies for these disorders. It codes for the η subtype of the 14‐3‐3 protein family, is expressed mainly in brain, and is involved in HPA axis regulation. We investigated the association of YWHAH with BP in a large sample, consisting of 1211 subjects from 318 nuclear families including 554 affected offspring. We tested for association with the standard BP phenotype as well as subtypes defined by psychotic and mood‐incongruent features. We genotyped five tag SNPs and the (GCCTGCA)n polymorphic locus present in this gene. Using a family‐based association test, we found that rs2246704 was associated with BP (OR 1.31, P = 0.03) and psychotic BP (OR = 1.66, P = 0.002). The polymorphic repeat and two other SNPs were also modestly associated with psychotic BP. We have provided additional evidence for association of variants in YWHAH with major mental illness. Additional association analyses of larger sample sets will be required to clarify the role of YWHAH in schizophrenia and BP. The use of clinical sub‐phenotypes such as psychotic features or other potential schizophrenia/BP overlap variables including cognitive abnormalities and poor functioning might shed further light on the potential subtypes of illness most closely associated with genetic variation in YWHAH. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - 14‐3‐3
KW - YWHAH
KW - bipolar disorder
KW - psychosis
KW - schizophrenia
KW - 2009
KW - Bipolar Disorder
KW - Genetic Linkage
KW - Schizophrenia
KW - Nuclear Family
KW - Psychosis
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH-042243. Recipients: Potash, James B.
U1 - Sponsor: National Institute of Mental Health, US. Grant: R01 MH-061613. Recipients: Gershon, Elliot S.
U1 - Sponsor: National Alliance for Research on Schizophrenia and Depression. Recipients: No recipient indicated
U1 - Sponsor: Stanley Medical Research Institute. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Mental Health, Intramural Research Program, US. Recipients: McMahon, Francis J.
DO - 10.1002/ajmg.b.30927
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2014-15908-011&site=ehost-live&scope=site
UR - ORCID: 0000-0002-9469-305X
UR -
UR - jpotash@jhmi.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Cho, Sungho
AU - Lee, Rena
AU - Yun, Min-Seok
AU - Jang, Gi-Won
AU - Park, Jikoon
AU - Choi, Jang-Yong
AU - Nam, Sanghee
T1 - A hybrid radiation detector based on a plasma display panel
JO - Nuclear Instruments & Methods in Physics Research Section A
JF - Nuclear Instruments & Methods in Physics Research Section A
Y1 - 2009/10/11/
VL - 609
IS - 2/3
M3 - Article
SP - 172
EP - 176
SN - 01689002
AB - Abstract: Recently, large-area image detectors have been investigated for X-ray imaging in medical diagnostic and other applications. In this paper, a new type of radiation detector is described, based on the integration of a photoconductor into a plasma display panel (PDP). This device, called a hybrid PDP detector, should be quite inexpensive, because it can directly leverage off the fabrication and materials technologies widely used in plasma display panels. Also, these new radiation detectors should operate under the most challenging environmental conditions, because they are inherently rugged and radiation-resistant and insensitive to magnetic fields. In this paper, we describe a hybrid digital radiation detector device, based on plasma display. The PDP panel is 7in. in size with a 1000-μm pixel pitch, and filled with 700Torr of Xe gas; the hybrid PDP panel is of the same structure, except for the photoconductor deposit. The glass absorption, dark current, X-ray sensitivity, and linearity as a function of electric field were measured to investigate its electrical properties. From the results, stabilized dark current density and significant X-ray sensitivity were obtained with both panels; however, the hybrid PDP detector showed better characteristics than the PDP detector. It also had good signal response and linearity. The hybrid digital radiation detector device based on a plasma display seems to be a promising technology for use in radiology and dynamic moving imaging. [Copyright &y& Elsevier]
AB - Copyright of Nuclear Instruments & Methods in Physics Research Section A is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NUCLEAR counters
KW - PLASMA displays
KW - IMAGE converters
KW - X-rays
KW - DIAGNOSIS
KW - PHOTOCONDUCTIVITY
KW - MICROFABRICATION
KW - Hybrid detector
KW - Photoconductor
KW - Plasma display panel
KW - X-ray detector
N1 - Accession Number: 44581060; Cho, Sungho 1 Lee, Rena 1 Yun, Min-Seok 2 Jang, Gi-Won 2 Park, Jikoon 3 Choi, Jang-Yong 4 Nam, Sanghee 2; Email Address: nsh@bme.inje.ac.kr; Affiliation: 1: Radiation Oncology, Ewha Womans University Mokdong Hospital, Seoul 158-710, Korea 2: Department of Biomedical Engineering, Inje University, Gimhae 621-749, Korea 3: Department of Radiology Science, International University of Korea, Jinjoo 660-759, Korea 4: Korea Food and Drug Administration, Seoul 122-704, Korea; Source Info: Oct2009, Vol. 609 Issue 2/3, p172; Subject Term: NUCLEAR counters; Subject Term: PLASMA displays; Subject Term: IMAGE converters; Subject Term: X-rays; Subject Term: DIAGNOSIS; Subject Term: PHOTOCONDUCTIVITY; Subject Term: MICROFABRICATION; Author-Supplied Keyword: Hybrid detector; Author-Supplied Keyword: Photoconductor; Author-Supplied Keyword: Plasma display panel; Author-Supplied Keyword: X-ray detector; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.nima.2009.06.034
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44581060&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2010-00372-001
AN - 2010-00372-001
AU - Dausey, David J.
AU - Pincus, Harold A.
AU - Herrell, James M.
T1 - Performance measurement for co-occurring mental health and substance use disorders.
JF - Substance Abuse Treatment, Prevention, and Policy
JO - Substance Abuse Treatment, Prevention, and Policy
JA - Subst Abuse Treat Prev Policy
Y1 - 2009/10/14/
VL - 4
CY - United Kingdom
PB - BioMed Central Limited
SN - 1747-597X
AD - Dausey, David J., Carnegie Mellon University, Pittsburgh, PA, US, 15213
N1 - Accession Number: 2010-00372-001. PMID: 19828034 Partial author list: First Author & Affiliation: Dausey, David J.; Carnegie Mellon University, Pittsburgh, PA, US. Release Date: 20100503. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Comorbidity; Drug Abuse; Mental Disorders; Quality of Care. Minor Descriptor: Measurement; Performance; Substance Use Disorder. Classification: Psychological & Physical Disorders (3200). Population: Human (10). Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. ArtID: 18. Issue Publication Date: Oct 14, 2009. Publication History: First Posted Date: Oct 14, 2009; Accepted Date: Oct 14, 2009; First Submitted Date: Jun 26, 2009. Copyright Statement: Dausey et al; licensee BioMed Central Ltd. 2009.
AB - Background: Co-occurring mental health and substance use disorders (COD) are the norm rather than the exception. It is therefore critical that performance measures are developed to assess the quality of care for individuals with COD irrespective of whether they seek care in mental health systems or substance abuse systems or both. Methods: We convened an expert panel and asked them to rate a series of structure, process, and outcomes measures for COD using a structured evaluation tool with domains for importance, usefulness, validity, and practicality. Results: We chose twelve measures that demonstrated promise for future pilot testing and refinement. The criteria that we applied to select these measures included: balance across structure, process, and outcome measures, quantitative ratings from the panelists, narrative comments from the panelists, and evidence the measure had been tested in a similar form elsewhere. Conclusion: To be successful performance measures need to be developed in such a way that they align with needs of administrators and providers. Policymakers need to work with all stakeholders to establish a concrete agenda for developing, piloting and implementing performance measures that include COD. Future research could begin to consider strategies that increase our ability to use administrative coding in mental health and substance use disorder systems to efficiently capture quality relevant clinical data. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - performance measurement
KW - co-occurring disorders
KW - mental health disorders
KW - substance use disorders
KW - quality of care
KW - 2009
KW - Comorbidity
KW - Drug Abuse
KW - Mental Disorders
KW - Quality of Care
KW - Measurement
KW - Performance
KW - Substance Use Disorder
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment (CSAT). Recipients: No recipient indicated
U1 - Sponsor: Robert Wood Johnson Foundation, Substance Abuse Policy Research Program (SAPRP). Recipients: No recipient indicated
DO - 10.1186/1747-597X-4-18
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-00372-001&site=ehost-live&scope=site
UR - jimherrell@verizon.net
UR - pincush@pi.cpmc.columbia.edu
UR - dausey@rand.org
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Zaitseva, Marina
AU - Kapnick, Senta M.
AU - Scott, John
AU - King, Lisa R.
AU - Manischewitz, Jody
AU - Sirota, Lev
AU - Kodihalli, Shantha
AU - Golding, Hana
T1 - Application of Bioluminescence Imaging to the Prediction of Lethality in Vaccinia Virus-Infected Mice.
JO - Journal of Virology
JF - Journal of Virology
Y1 - 2009/10/15/
VL - 83
IS - 20
M3 - Article
SP - 15
EP - 15
SN - 0022538X
AB - To find an alternative endpoint for the efficacy of antismallpox treatments, bioluminescence was measured in live BALB/c mice following lethal challenge with a recombinant WR vaccinia virus expressing luciferase. Intravenous vaccinia immunoglobulin treatments were used to confer protection on a proportion of animals. Using known lethality outcomes in 200 animals and total fluxes recorded daily in live animals, we performed univariate receiver operating characteristic (ROC) curve analysis to assess whether lethality can be predicted based on bioluminescence. Total fluxes in the spleens on day 3 and in the livers on day 5 generated accurate predictive models; the area under the ROC curve (AUC) was 0.91. Multiple logistic regression analysis utilizing a linear combination of six measurements: total flux in the liver on days 2, 3, and 5; in the spleen on days 1 and 3; and in the nasal cavity on day 4 generated the most accurate predictions (AUC = 0.96). This model predicted lethality in 90% of animals with only 10% of nonsurviving animals incorrectly predicted to survive. Compared with bioluminescence, ROC analysis with 25% and 30% weight loss as thresholds accurately predicted survival on day 5, but lethality predictions were low until day 9. Collectively, our data support the use of bioimaging for lethality prediction following vaccinia virus challenge and for gaining insight into protective mechanisms conferred by vaccines and therapeutics. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Virology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINIA
KW - BIOLUMINESCENCE
KW - RECEIVER operating characteristic curves
KW - IMMUNOGLOBULINS -- Therapeutic use
KW - VETERINARY therapeutics
KW - TREATMENT
KW - THERAPEUTIC use
N1 - Accession Number: 44481878; Zaitseva, Marina 1; Email Address: marina.zaitseva@fda.hhs.gov Kapnick, Senta M. 1 Scott, John 1 King, Lisa R. 1 Manischewitz, Jody 1 Sirota, Lev 1 Kodihalli, Shantha 2 Golding, Hana 1; Affiliation: 1: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 2: Department of Clinical Research, Cangene Corporation, Winnipeg, Manitoba, Canada R3T5X8; Source Info: Oct2009, Vol. 83 Issue 20, p15; Subject Term: VACCINIA; Subject Term: BIOLUMINESCENCE; Subject Term: RECEIVER operating characteristic curves; Subject Term: IMMUNOGLOBULINS -- Therapeutic use; Subject Term: VETERINARY therapeutics; Subject Term: TREATMENT; Subject Term: THERAPEUTIC use; Number of Pages: 1p; Document Type: Article
L3 - 10.1128/JVI.01296-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44481878&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Choudhuri, Supratim
T1 - Lesser known relatives of miRNA
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2009/10/16/
VL - 388
IS - 2
M3 - Article
SP - 177
EP - 180
SN - 0006291X
AB - Abstract: Since the discovery of RNAi (RNA interference) major attention has focused on studying miRNA (microRNA) and siRNA (small interfering RNA). However, within the last few years, several other small ncRNAs (non-coding RNAs) have been discovered and thus various newer acronyms representing these ‘other’ classes of small ncRNAs have populated the literature. Of these, piRNA (Piwi-interacting RNA) has been gaining importance because of its role as the guardian of the germline genome. Some of the other newly discovered small ncRNAs have been mostly reported in plants, and they are yet to be studied more comprehensively. Nevertheless, piRNA and the ‘other’ small ncRNAs deserve some discussion because they are members of the increasingly large family of small ncRNAs. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NON-coding RNA
KW - SMALL interfering RNA
KW - INTERFERON inducers
KW - GENETIC research
KW - MEDICAL literature
KW - GERM cells
KW - GENOMES
KW - hc-siRNA
KW - nat-siRNA
KW - piRNA
KW - qiRNA
KW - ra-siRNA
KW - scnRNA
KW - ta-siRNA
N1 - Accession Number: 43976772; Choudhuri, Supratim 1; Email Address: Supratim.Choudhuri@fda.hhs.gov; Affiliation: 1: U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Biotechnology and GRAS Notice Review, OFAS/DBGNR, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA; Source Info: Oct2009, Vol. 388 Issue 2, p177; Subject Term: NON-coding RNA; Subject Term: SMALL interfering RNA; Subject Term: INTERFERON inducers; Subject Term: GENETIC research; Subject Term: MEDICAL literature; Subject Term: GERM cells; Subject Term: GENOMES; Author-Supplied Keyword: hc-siRNA; Author-Supplied Keyword: nat-siRNA; Author-Supplied Keyword: piRNA; Author-Supplied Keyword: qiRNA; Author-Supplied Keyword: ra-siRNA; Author-Supplied Keyword: scnRNA; Author-Supplied Keyword: ta-siRNA; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.bbrc.2009.08.039
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=43976772&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Williams, Anna J.
AU - Park, Miseon
AU - Sims, Lillie M.
AU - Heinze, Thomas M.
AU - Cerniglia, Carl E.
AU - Sutherland, John B.
T1 - Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur
JO - Veterinary Microbiology
JF - Veterinary Microbiology
Y1 - 2009/10/20/
VL - 139
IS - 1/2
M3 - Article
SP - 89
EP - 96
SN - 03781135
AB - Abstract: Ceftiofur, a third-generation cephalosporin used to treat bacterial infections in animals, is degraded in bovine feces but the specific bacteria involved are unknown. To find the bacteria involved in ceftiofur metabolism, the bovine fecal microflora was screened. Twenty-one nonidentical strains of bovine fecal bacteria were isolated on media containing 1–32μgml−1 of ceftiofur. The cultures were incubated with 5μgml−1 ceftiofur for different times, then centrifuged and analyzed by high-performance liquid chromatography. Three strains of Bacillus spp., two strains of Roseomonas spp., and one strain of Azospirillum sp. metabolized 5μgml−1 ceftiofur in broth cultures in less than 24h; ten other strains of Roseomonas and one strain of Bacillus pumilus had metabolized it by 120h. After the ceftiofur had been metabolized by these bacteria, the filter-sterilized supernatants of centrifuged cultures no longer inhibited the growth of a ceftiofur-sensitive strain of Kocuria rhizophila, which indicated that ceftiofur had been transformed to compounds without bactericidal activity. Each isolate was also found to be able to grow in the presence of other β-lactams, and a nitrocefin assay showed β-lactamase activity in the 17 strains that metabolized ceftiofur. The results show that some β-lactamase-producing bacteria from the bovine fecal microflora are capable of transforming ceftiofur to metabolites lacking bactericidal activity. [Copyright &y& Elsevier]
AB - Copyright of Veterinary Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CATTLE -- Physiology
KW - FECES -- Examination
KW - FECAL microbiology
KW - ANTIBIOTICS
KW - BIODEGRADATION
KW - VETERINARY medicine
KW - ANTIBACTERIAL agents
KW - BACTERIAL diseases in children
KW - BETA lactamases
KW - TREATMENT
KW - Beta-lactamases
KW - Biodegradation
KW - Ceftiofur
KW - Cephalosporins
N1 - Accession Number: 44417321; Rafii, Fatemeh 1 Williams, Anna J. 1 Park, Miseon 1 Sims, Lillie M. 1 Heinze, Thomas M. 2 Cerniglia, Carl E. 1 Sutherland, John B. 1; Email Address: john.sutherland@fda.hhs.gov; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, AR 72079, USA 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, AR 72079, USA; Source Info: Oct2009, Vol. 139 Issue 1/2, p89; Subject Term: CATTLE -- Physiology; Subject Term: FECES -- Examination; Subject Term: FECAL microbiology; Subject Term: ANTIBIOTICS; Subject Term: BIODEGRADATION; Subject Term: VETERINARY medicine; Subject Term: ANTIBACTERIAL agents; Subject Term: BACTERIAL diseases in children; Subject Term: BETA lactamases; Subject Term: TREATMENT; Author-Supplied Keyword: Beta-lactamases; Author-Supplied Keyword: Biodegradation; Author-Supplied Keyword: Ceftiofur; Author-Supplied Keyword: Cephalosporins; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 541940 Veterinary Services; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vetmic.2009.04.023
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44417321&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Davies, A. P.
AU - Chalmers, R. M.
T1 - Cryptosporidiosis.
JO - BMJ: British Medical Journal (Overseas & Retired Doctors Edition)
JF - BMJ: British Medical Journal (Overseas & Retired Doctors Edition)
Y1 - 2009/10/24/
VL - 339
IS - 7727
M3 - Article
SP - 963
EP - 967
SN - 17592151
AB - The article presents a review which examined the epidemiology, clinical presentation, diagnosis and management of cryptosporidiosis. The disease is caused by Cryptosporidium, a protozoan parasite that can cause diarrhoeal illness around the world. The risk factors for acquisition of Cryptosporidium include drinking contaminated water and travel to developing countries. The clinical features of the disease include a gastroenteritis-like syndrome and the experience of chronic or intractable disease.
KW - CRYPTOSPORIDIOSIS
KW - CRYPTOSPORIDIUM
KW - PROTOZOAN diseases
KW - GASTROENTERITIS
KW - CONTAMINATION of drinking water
KW - DEVELOPING countries
N1 - Accession Number: 45062156; Davies, A. P. 1; Email Address: angharad.p.davies@swansea.ac.uk Chalmers, R. M. 2; Affiliation: 1: School of Medicine, Swansea University, Swansea SA2 8PP 2: UK Cryptosporidium Reference Unit, National Public Health Service for Wales, Swansea; Source Info: 10/24/2009, Vol. 339 Issue 7727, p963; Subject Term: CRYPTOSPORIDIOSIS; Subject Term: CRYPTOSPORIDIUM; Subject Term: PROTOZOAN diseases; Subject Term: GASTROENTERITIS; Subject Term: CONTAMINATION of drinking water; Subject Term: DEVELOPING countries; Number of Pages: 5p; Illustrations: 3 Color Photographs, 1 Chart; Document Type: Article
L3 - 10.1136/bmj.b4168
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45062156&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lee, Jong-Ho
AU - Cha, Kyung Eun
AU - Kim, Min Soo
AU - Hong, Hye Won
AU - Chung, Dong June
AU - Ryu, Gyuha
AU - Myung, Heejoon
T1 - Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/10/28/
VL - 190
IS - 2
M3 - Article
SP - 202
EP - 207
SN - 03784274
AB - Abstract: Nano-materials are currently being used in a variety of fields. One of the concerns associated with their use is their potential to harm human health. In an attempt to identify genes expressed differently in human lung cells (WI-26 VA4) exposed to nanosized (45nm in diameter) PAMAM (polyamidoamine) dendrimers, we observed down-regulation of mitochondrial DNA-encoded genes involved in the maintenance of mitochondrial membrane potential. Down-regulation of gene expression was confirmed by semi-quantitative RT-PCR. Dendrimers were shown to colocalize with mitochondria and cause the release of cytochrome C. Mitochondrial membrane potential was disrupted and the viability of cells was decreased in the presence of dendrimers. Activation of caspases 3 and 9 was increased. Apoptosis was observed by annexin V/propidium iodide staining and DNA fragmentation. In summary, nanosized dendrimers damaged mitochondria resulting in apoptosis. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chemicals -- Physiological effect
KW - Apoptosis
KW - Dendrimers
KW - Mitochondrial physiology
KW - Gene expression
KW - Polymers
KW - Polymerase chain reaction
KW - Polymerase chain reaction -- Diagnostic use
KW - Mitochondrial membranes
KW - Nanostructured materials
KW - Cytochrome c
KW - Cytotoxicity
KW - Membrane potential
KW - Mitochondria
KW - Nano-dendrimer
N1 - Accession Number: 44118113; Lee, Jong-Ho 1; Cha, Kyung Eun 1; Kim, Min Soo 1; Hong, Hye Won 1; Chung, Dong June 2; Ryu, Gyuha 3; Myung, Heejoon 1,4; Email Address: hjmyung@hufs.ac.kr; Affiliations: 1: Department of Bioscience and Biotechnology, Hankuk University of Foreign Studies, Yong-In, Gyung-Gi Do 449-791, Republic of Korea; 2: Department of Polymer Science and Engineering, Sunkyunkwan University, Suwon, Gyung-Gi Do 440-746, Republic of Korea; 3: Korea Food and Drug Administration, Seoul 122-704, Republic of Korea; 4: Protein Research Center for Bio-Industry, Hankuk University of Foreign Studies, Yong-In, Gyung-Gi Do 449-791, Republic of Korea; Issue Info: Oct2009, Vol. 190 Issue 2, p202; Thesaurus Term: Chemicals -- Physiological effect; Thesaurus Term: Apoptosis; Subject Term: Dendrimers; Subject Term: Mitochondrial physiology; Subject Term: Gene expression; Subject Term: Polymers; Subject Term: Polymerase chain reaction; Subject Term: Polymerase chain reaction -- Diagnostic use; Subject Term: Mitochondrial membranes; Subject Term: Nanostructured materials; Subject Term: Cytochrome c; Author-Supplied Keyword: Cytotoxicity; Author-Supplied Keyword: Membrane potential; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: Nano-dendrimer; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.toxlet.2009.07.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44118113&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Yuan, B.-Z.
AU - Chapman, J.
AU - Reynolds, S. H.
T1 - Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage.
JO - Oncogene
JF - Oncogene
Y1 - 2009/10/29/
VL - 28
IS - 43
M3 - Article
SP - 3775
EP - 3786
PB - Nature Publishing Group
SN - 09509232
AB - Proteasome inhibitors (PIs) are promising new therapeutic agents for treating non-small cell lung carcinoma (NSCLC). To investigate the mechanisms of action of PIs, we analyzed the proapoptotic activities of PIs (MG132 or Bortezomib) in NSCLC cells. We found that both MG132 (>1 μM) and Bortezomib (>0.025 μM) induced a significant apoptosis in NCI-H1703, a PI-sensitive NSCLC cell line, through initially activating the intrinsic apoptosis pathway, leading to the activation of a positive feedback mechanism (PFM), which then conveyed apoptosis signaling from the intrinsic pathway to the extrinsic pathway with formation of a signaling loop for maximal caspase activation. Mcl-1 and Noxa were identified to be the major anti-apoptotic and proapoptotic proteins, respectively, in PI-induced apoptosis and mutually exclusive in protein stability. Although the Mcl-1 protein was upregulated by proteasome inhibition, it was also subjected to caspase 3-dependent cleavage governed by the PFM. Moreover, it was revealed that Mcl-1 protein cleavage contributed to PFM-governed apoptosis in following inter-related ways: reducing the anti-apoptotic Mcl-1; generating the truncated proapoptotic Mcl-1S; and inducing a shift of balance between Mcl-1 and Noxa. It was further manifested that tumor necrosis factor-related apoptosis-inducing ligand boosted MG132's proapoptotic activity through strengthening the PFM in both NCI-H1703 and NCI-H358, a PI-resistant NSCLC cell line. Therefore, this study provides a basis for enhancing the efficacy of PIs in treating NSCLC. [ABSTRACT FROM AUTHOR]
AB - Copyright of Oncogene is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - APOPTOSIS
KW - CANCER cells
KW - LUNGS -- Cancer -- Treatment
KW - CELL lines
KW - TUMOR necrosis factor
KW - apoptosis
KW - Mcl-1
KW - non-small cell lung carcinoma
KW - positive feedback mechanism
KW - proteasome inhibitor
KW - protein cleavage
N1 - Accession Number: 44869180; Yuan, B.-Z. 1; Email Address: bby1@cdc.gov Chapman, J. 1 Reynolds, S. H. 1; Affiliation: 1: Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV, USA; Source Info: 10/29/2009, Vol. 28 Issue 43, p3775; Subject Term: APOPTOSIS; Subject Term: CANCER cells; Subject Term: LUNGS -- Cancer -- Treatment; Subject Term: CELL lines; Subject Term: TUMOR necrosis factor; Author-Supplied Keyword: apoptosis; Author-Supplied Keyword: Mcl-1; Author-Supplied Keyword: non-small cell lung carcinoma; Author-Supplied Keyword: positive feedback mechanism; Author-Supplied Keyword: proteasome inhibitor; Author-Supplied Keyword: protein cleavage; Number of Pages: 12p; Illustrations: 6 Black and White Photographs, 1 Diagram, 2 Graphs; Document Type: Article
L3 - 10.1038/onc.2009.240
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44869180&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Reuter, G.
AU - Pankovics, P.
AU - Egyed, L.
T1 - Detection of genotype 1 and 2 bovine noroviruses in Hungary.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2009/10/31/
VL - 165
IS - 18
M3 - Article
SP - 538
EP - 539
SN - 00424900
AB - The article focuses on the study which examines the genotype interaction of bovine caliciviruses known as noroviruses in Hungary. Based on the reverse transcriptase polymerase chain reaction (PCR) report, there was a full-length capsid sequence and the possibility of genetic recombination at the RNA polymerase region. Detection and characterization of norovirus strains of cattle has been reviewed to evaluate its genetic or antigenic heterogeneity effects in different geographic regions.
KW - GENOTYPE-environment interaction
KW - NOROVIRUSES
KW - RNA viruses
KW - POLYMERASE chain reaction
KW - GENETIC research
KW - HUNGARY
N1 - Accession Number: 45222605; Reuter, G. 1; Email Address: reuter.gabor@baranya.antsz.hu Pankovics, P. 2 Egyed, L. 2; Affiliation: 1: Regional Laboratory of Virology, ÁNTSZ, Regional Institute of State Public Health Service, H-7623, Szabadság u. 7, Pécs, Hungary 2: Medical Research Institute of the Hungarian Academy of Sciences, H-1581 PO Box 18, Budapest, Hungary; Source Info: 10/31/2009, Vol. 165 Issue 18, p538; Subject Term: GENOTYPE-environment interaction; Subject Term: NOROVIRUSES; Subject Term: RNA viruses; Subject Term: POLYMERASE chain reaction; Subject Term: GENETIC research; Subject Term: HUNGARY; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 2p; Illustrations: 1 Diagram; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105235957
T1 - High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots.
AU - Yong LC
AU - Petersen MR
AU - Sigurdson AJ
AU - Sampson LA
AU - Ward EM
Y1 - 2009/11//
N1 - Accession Number: 105235957. Language: English. Entry Date: 20100101. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Nutrition. Grant Information: Supported in part by the National Institute for Occupational Safety and Health and the National Cancer Institute and by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute. NLM UID: 0376027.
KW - Ascorbic Acid
KW - Carotenoids
KW - Chromosome Disorders
KW - Diet
KW - Pilots
KW - Vitamin E
KW - Adult
KW - Beta Carotene
KW - Body Mass Index -- Evaluation
KW - Chi Square Test
KW - Confidence Intervals
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Funding Source
KW - Human
KW - In Situ Hybridization, Fluorescence
KW - Lutein
KW - Male
KW - Middle Age
KW - Multivariate Analysis
KW - Nutritional Assessment
KW - Occupational Exposure
KW - Occupational Health
KW - Odds Ratio
KW - Questionnaires
KW - Radiation, Ionizing
KW - Regression
KW - Self Report
KW - Statistical Significance
KW - Two-Tailed Test
KW - United States
KW - Zeaxanthin
SP - 1402
EP - 1410
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
JA - AM J CLIN NUTR
VL - 90
IS - 5
CY - Bethesda, Maryland
PB - American Society for Nutrition
AB - BACKGROUND: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. OBJECTIVE: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. DESIGN: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. RESULTS: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios (95% CI) for > or =median compared with or =median compared with 10 000/g dry tissue in all samples examined except in the small intestine. The number of asbestos fibers in the stomach was 53 000/g, which was higher than that in a control asbestosis subject. The existence of numerous asbestos fibers found in the abdominal cavity suggests that asbestos stimuli are related to the tumorigenesis of malignant peritoneal mesothelioma. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pathology International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MESOTHELIOMA
KW - PLEURA
KW - ASBESTOS
KW - PERITONEUM
KW - TUMORS
KW - asbestos body
KW - asbestos fiber
KW - malignant peritoneal mesothelioma
N1 - Accession Number: 44813522; Kurimoto, Ryota 1 Kishimoto, Takashi 2; Email Address: tkishi@faculty.chiba-u.jp Nagai, Yuichiro 3 Takazawa, Hiroshi 4 Sakaue, Nobuyuki 4 Shinohara, Yasushi 5 Hiroshima, Kenzo 6; Affiliation: 1: Chiba University School of Medicine, Chiba Japan. 2: Department of Molecular Pathology, Chiba Japan. 3: National Hospital Organization, Chiba Medical Center, Chiba Japan. 4: Chiba Rosai Hospital, Chiba Japan. 5: Work Environment Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan. 6: Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba Japan.; Source Info: Nov2009, Vol. 59 Issue 11, p823; Subject Term: MESOTHELIOMA; Subject Term: PLEURA; Subject Term: ASBESTOS; Subject Term: PERITONEUM; Subject Term: TUMORS; Author-Supplied Keyword: asbestos body; Author-Supplied Keyword: asbestos fiber; Author-Supplied Keyword: malignant peritoneal mesothelioma; NAICS/Industry Codes: 212394 Asbestos mining; NAICS/Industry Codes: 327999 All Other Miscellaneous Nonmetallic Mineral Product Manufacturing; NAICS/Industry Codes: 212399 All Other Nonmetallic Mineral Mining; Number of Pages: 5p; Illustrations: 2 Color Photographs, 1 Black and White Photograph, 2 Charts; Document Type: Article
L3 - 10.1111/j.1440-1827.2009.02452.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44813522&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Honberg, Lynda E.
AU - Kogan, Michael D.
AU - Allen, Deborah
AU - Strickland, Bonnie B.
AU - Newacheck, Paul W.
T1 - Progress in Ensuring Adequate Health Insurance for Children With Special Health Care Needs.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/11//
VL - 124
IS - 5
M3 - Article
SP - 1273
EP - 1280
SN - 00314005
AB - OBJECTIVE: This article reports findings from the 2005-2006 National Survey of Children With Special Health Care Needs (NS-CSHCN) regarding the extent to which CSHCN have access to public or private health insurance that meets their needs. METHODS: The HRSA Maternal and Child Health Bureau's health insurance core outcome was measured on the basis of whether a child had public or private coverage at the time of survey; continuity of coverage during the previous 12 months; and adequacy of coverage. Bivariate and multivariate statistical methods were used to assess independent predictors of respondents who met the health insurance core outcome and the impact of meeting the core outcome on measures of access and financial burden. Comparisons with a referent sample of children who did and did not have special needs and were included in the 2001 NS-CSHCN are also presented. RESULTS: A total of 62.0% of CSHCN nationally met the health insurance core outcome in 2005-2006, up from 59.6% in 2001. Disparities by ethnicity and income remain, but some have narrowed, especially for Hispanic CSHCN. Children who did not meet the health insurance core outcome were more likely to have unmet needs and their families to experience financial problems. CSHCN were more likely to be insured than children without special needs but less likely to be adequately insured. CONCLUSIONS: Results of the survey demonstrate that although a growing number of CSHCN have continuous and adequate health insurance, additional effort is needed to improve the adequacy of that insurance, particularly for children in vulnerable subpopulations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEALTH insurance
KW - CHILDREN with disabilities
KW - HEALTH surveys
KW - MULTIVARIATE analysis
KW - SAMPLING (Statistics)
KW - CHILD care
KW - NEEDS assessment (Medical care)
KW - CHILDREN -- Health
KW - access to care
KW - children with special health care needs
KW - health insurance
KW - National Survey of Children with Special Health Care Needs
N1 - Accession Number: 45407644; Honberg, Lynda E. 1; Email Address: lhonberg@hrsa.gov Kogan, Michael D. 1 Allen, Deborah 2 Strickland, Bonnie B. 1 Newacheck, Paul W. 3; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland 2: Bureau of Child, Adolescent and Family Health, Boston Public Health Commission, Boston, Massachusetts 3: Institute for Health Policy Studies and Department of Pediatrics, University of California at San Francisco, San Francisco, California; Source Info: Nov2009, Vol. 124 Issue 5, p1273; Subject Term: HEALTH insurance; Subject Term: CHILDREN with disabilities; Subject Term: HEALTH surveys; Subject Term: MULTIVARIATE analysis; Subject Term: SAMPLING (Statistics); Subject Term: CHILD care; Subject Term: NEEDS assessment (Medical care); Subject Term: CHILDREN -- Health; Author-Supplied Keyword: access to care; Author-Supplied Keyword: children with special health care needs; Author-Supplied Keyword: health insurance; Author-Supplied Keyword: National Survey of Children with Special Health Care Needs; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 8p; Illustrations: 6 Charts; Document Type: Article
L3 - 10.1542/peds.2009-0372
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45407644&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105242299
T1 - Progress in ensuring adequate health insurance for children with special health care needs.
AU - Honberg LE
AU - Kogan MD
AU - Allen D
AU - Strickland BB
AU - Newacheck PW
Y1 - 2009/11//
N1 - Accession Number: 105242299. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0376422.
KW - Child, Medically Fragile
KW - Health Services Accessibility
KW - Insurance Coverage
KW - Insurance, Health
KW - Bivariate Statistics
KW - Child
KW - Child, Preschool
KW - Female
KW - Human
KW - Infant
KW - Infant, Newborn
KW - Interviews
KW - Logistic Regression
KW - Male
KW - Multivariate Statistics
KW - Questionnaires
KW - Socioeconomic Factors
KW - United States
SP - 1273
EP - 1280
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 124
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - Objective: This article reports findings from the 2005-2006 National Survey of Children With Special Health Care Needs (NS-CSHCN) regarding the extent to which CSHCN have access to public or private health insurance that meets their needs. Methods: The HRSA Maternal and Child Health Bureau's health insurance core outcome was measured on the basis of whether a child had public or private coverage at the time of survey; continuity of coverage during the previous 12 months; and adequacy of coverage. Bivariate and multivariate statistical methods were used to assess independent predictors of respondents who met the health insurance core outcome and the impact of meeting the core outcome on measures of access and financial burden. Comparisons with a referent sample of children who did and did not have special needs and were included in the 2001 NS-CSHCN are also presented. Results: A total of 62.0% of CSHCN nationally met the health insurance core outcome in 2005-2006, up from 59.6% in 2001. Disparities by ethnicity and income remain, but some have narrowed, especially for Hispanic CSHCN. Children who did not meet the health insurance core outcome were more likely to have unmet needs and their families to experience financial problems. CSHCN were more likely to be insured than children without special needs but less likely to be adequately insured. Conclusions: Results of the survey demonstrate that although a growing number of CSHCN have continuous and adequate health insurance, additional effort is needed to improve the adequacy of that insurance, particularly for children in vulnerable subpopulations.
SN - 0031-4005
AD - Fishers La, Room 18A18, Parklawn Building, Rockville, MD 20857; lhonberg@hrsa.gov
U2 - PMID: 19822584.
DO - 10.1542/peds.2009-0372
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105242299&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105243105
T1 - Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007.
AU - Kogan MD
AU - Blumberg SJ
AU - Schieve LA
AU - Boyle CA
AU - Perrin JM
AU - Ghandour RM
AU - Singh GK
AU - Strickland BB
AU - Trevathan E
AU - van Dyck PC
Y1 - 2009/11//
N1 - Accession Number: 105243105. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: Supported in part by Autism Speaks and the Health Resources and Services Administration Maternal and Child Health Bureau. NLM UID: 0376422.
KW - Autistic Disorder -- Epidemiology
KW - Parents
KW - Prevalence
KW - Self Diagnosis
KW - Adolescence
KW - Autistic Disorder -- Diagnosis
KW - Child
KW - Child, Preschool
KW - Female
KW - Funding Source
KW - Human
KW - Interviews
KW - Male
KW - Random Sample
SP - 1395
EP - 1403
JO - Pediatrics
JF - Pediatrics
JA - PEDIATRICS
VL - 124
IS - 5
CY - Chicago, Illinois
PB - American Academy of Pediatrics
AB - Objectives: The reported increasing prevalence of autism spectrum disorder (ASD) and attendant health and family impact make monitoring of ASD prevalence a public health priority. Methods: The prevalence of parent-reported diagnosis of ASD among US children aged 3 to 17 years was estimated from the 2007 National Survey of Children's Health (sample size: 78037). A child was considered to have ASD if a parent/guardian reported that a doctor or other health care provider had ever said that the child had ASD and that the child currently had the condition. The point-prevalence for ASD was calculated for those children meeting both criteria. We examined sociodemographic factors associated with current ASD and with a past (but not current) ASD diagnosis. The health care experiences for children in both ASD groups were explored. Results: The weighted current ASD point-prevalence was 110 per 10,000. We estimate that 673,000 US children have ASD. Odds of having ASD were 4 times as large for boys than girls. Non-Hispanic (NH) black and multiracial children had lower odds of ASD than NH white children. Nearly 40% of those ever diagnosed with ASD did not currently have the condition; NH black children were more likely than NH white children to not have current ASD. Children in both ASD groups were less likely than children without ASD to receive care within a medical home. Conclusions: The observed point-prevalence is higher than previous US estimates. More inclusive survey questions, increased population awareness, and improved screening and identification by providers may partly explain this finding.
SN - 0031-4005
AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland
U2 - PMID: 19805460.
DO - 10.1542/peds.2009-1522
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105243105&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Adhikary, Ramkrishna
AU - Schönenbrücher, Holger
AU - Rasmussen, Mark A.
AU - Casey, Thomas A.
AU - Hamir, Amir N.
AU - Kehrli, Marcus E.
AU - Richt, Jürgen A.
AU - Petrich, Jacob W.
T1 - A Comparison of the Fluorescence Spectra of Murine and Bovine Central Nervous System and Other Tissues.
JO - Photochemistry & Photobiology
JF - Photochemistry & Photobiology
Y1 - 2009/11//
VL - 85
IS - 6
M3 - Article
SP - 1322
EP - 1326
SN - 00318655
AB - We describe a comparison of the fluorescence spectra of bovine tissues with murine tissues in order to determine whether spectral features are conserved and whether an appropriate and practical laboratory small animal model system could be identified to be used for investigation of tissue- and age-related fluorescence signal patterns. Recently it has been shown that spectral signatures of lipofuscin have enabled the detection of bovine central nervous system (CNS) tissue in meat products with high sensitivity (Schönenbrücher, H., Adhikary, R., Mukherjee, P., Casey, T.A., Rasmussen, M.A., Maistrovich, F.D., Hamir, A.N., Kehrli, M.J., Richt, J., Petrich, J.W. [2008] J Agric Food Chem 56, 6220–6226). We report that brain and spinal cord of mice provide fluorescence spectra similar to those of bovine brain and spinal cord. It is concluded that murine CNS tissue is an appropriate model system for bovine CNS tissue for the development of fluorometric CNS detection assays. [ABSTRACT FROM AUTHOR]
AB - Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FLUORESCENCE
KW - CATTLE -- Anatomy
KW - MICE as laboratory animals
KW - TISSUE culture
KW - LIPOFUSCINS
N1 - Accession Number: 44758106; Adhikary, Ramkrishna 1 Schönenbrücher, Holger 2 Rasmussen, Mark A. 3,4 Casey, Thomas A. 4 Hamir, Amir N. 2 Kehrli, Marcus E. 2 Richt, Jürgen A. 2,5; Email Address: jricht@ksu.edu Petrich, Jacob W. 1; Email Address: jwp@iastate.edu; Affiliation: 1: Department of Chemistry, Iowa State University, Ames, IA. 2: Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA. 3: Office of Research, Center for Veterinary Medicine, U.S. FDA, Laurel, MD. 4: Pre-Harvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA. 5: Department of Diagnostic Medicine / Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS.; Source Info: Nov2009, Vol. 85 Issue 6, p1322; Subject Term: FLUORESCENCE; Subject Term: CATTLE -- Anatomy; Subject Term: MICE as laboratory animals; Subject Term: TISSUE culture; Subject Term: LIPOFUSCINS; NAICS/Industry Codes: 112130 Dual-Purpose Cattle Ranching and Farming; NAICS/Industry Codes: 112112 Cattle Feedlots; NAICS/Industry Codes: 424520 Livestock Merchant Wholesalers; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 111421 Nursery and Tree Production; Number of Pages: 5p; Illustrations: 6 Graphs; Document Type: Article
L3 - 10.1111/j.1751-1097.2009.00593.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105146638
T1 - Recent changes in Medicaid policy and their possible effects on mental health services.
AU - Buck JA
AU - Buck, Jeffrey A
Y1 - 2009/11//
N1 - Accession Number: 105146638. Language: English. Entry Date: 20100326. Revision Date: 20170307. Publication Type: journal article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Psychiatry/Psychology. NLM UID: 9502838.
KW - Medicaid -- Administration
KW - Mental Health Services -- Administration
KW - Community Mental Health Services -- Economics
KW - Community Mental Health Services -- Administration
KW - Health Policy
KW - Medicine
KW - Mental Health Services -- Economics
KW - United States
SP - 1504
EP - 1509
JO - Psychiatric Services
JF - Psychiatric Services
JA - PSYCHIATR SERV
VL - 60
IS - 11
CY - Arlington, Virginia
PB - American Psychiatric Publishing, Inc.
AB - As Medicaid has emerged as the primary funder of public mental health services, its character has affected the organization and delivery of such services. Recent changes to the program, however, promise to further affect the direction of changes in states' mental health service systems. One group of changes will further limit the flexibility of Medicaid mental health funding, while increasing provider accountability and the authority of state Medicaid agencies. Others will increase incentives for deinstitutionalization and community-based care and promote person-centered treatment principles. These changes will likely affect state mental health systems, mental health providers, and the nature of service delivery.
SN - 1075-2730
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA
AD - Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA. jeff.buck@samhsa.hhs.gov
U2 - PMID: 19880469.
DO - 10.1176/appi.ps.60.11.1504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105146638&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vernon, John A.
AU - Golec, Joseph H.
AU - Lutter, Randall
AU - Nardinelli, Clark
T1 - An exploratory study of FDA new drug review times, prescription drug user fee acts, and R&D spending
JO - Quarterly Review of Economics & Finance
JF - Quarterly Review of Economics & Finance
Y1 - 2009/11//
VL - 49
IS - 4
M3 - Article
SP - 1260
EP - 1274
SN - 10629769
AB - Abstract: FDA approval times have declined significantly since the enactment of the Prescription Drug User Fee Act (PDUFA) in 1992. As a result, present value expected returns to pharmaceutical R&D have likely increased. In the current paper we employ a unique survey dataset, one which includes data from 1990 to 1999 on firm-level pharmaceutical R&D expenditures for 7 large, U.S.-based drug companies. We estimate the effect FDA approval times have on firm R&D spending. Controlling for other factors such as pharmaceutical profitability and cash flows, we estimate that a 10% decrease (increase) in FDA approval times leads to an increase (decrease) in R&D spending from between 1.4% and 2.0%. Combining this estimate with recent research on the link between PDUFA and FDA approval times, we calculate that for the firms in our sample, R&D spending in the 1990s increased by an additional 5.0–7.2% as a result of this legislation. This amounted to an additional $3.2 billion to $4.6 billion in pharmaceutical R&D expenditures (2005 $US), and possibly several new drugs. Because PDUFA continued to provide incentives for R&D after 1999, and because it is probable that firms not in our sample were similarly affected by PDUFA, our estimates may be conservative. Considering more industry-wide measures of R&D expenditures over a similar time period (1992–2001) we calculate PDUFA may have incentivized an additional $10.8 billion to $15.4 billion in pharmaceutical R&D. Recent economic research has shown that the social rate of return on pharmaceutical R&D is very high; therefore, the social benefits of PDUFA (over and above the benefits of more rapid consumer access) are likely to be substantial. [Copyright &y& Elsevier]
AB - Copyright of Quarterly Review of Economics & Finance is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHARMACEUTICAL industry
KW - CASH flow
KW - PRESCRIPTION of drugs
KW - DRUG abuse
KW - DRUG delivery systems
KW - MEDICATION abuse
KW - MEDICAL care costs
KW - PHARMACEUTICAL policy
KW - FDA
KW - G38
KW - I0
KW - K23
KW - Prescription drug user fee act
KW - R&D spending
N1 - Accession Number: 45071679; Vernon, John A. 1,2; Email Address: vernon@email.unc.edu; Golec, Joseph H. 3; Lutter, Randall 4; Nardinelli, Clark 4; Affiliations: 1: Department of Health Policy and Management, The University of North Carolina at Chapel Hill, United States; 2: National Bureau of Economic Research, United States; 3: Department of Finance, University of Connecticut, United States; 4: Office of the Commissioner, U.S. Food and Drug Administration, United States; Issue Info: Nov2009, Vol. 49 Issue 4, p1260; Thesaurus Term: PHARMACEUTICAL industry; Thesaurus Term: CASH flow; Subject Term: PRESCRIPTION of drugs; Subject Term: DRUG abuse; Subject Term: DRUG delivery systems; Subject Term: MEDICATION abuse; Subject Term: MEDICAL care costs; Subject Term: PHARMACEUTICAL policy; Author-Supplied Keyword: FDA; Author-Supplied Keyword: G38; Author-Supplied Keyword: I0; Author-Supplied Keyword: K23; Author-Supplied Keyword: Prescription drug user fee act; Author-Supplied Keyword: R&D spending; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325412 Pharmaceutical Preparation Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.qref.2009.08.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=45071679&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Knight, Andrew W.
AU - Little, Stephen
AU - Houck, Keith
AU - Dix, David
AU - Judson, Richard
AU - Richard, Ann
AU - McCarroll, Nancy
AU - Akerman, Gregory
AU - Yang, Chihae
AU - Birrell, Louise
AU - Walmsley, Richard M.
T1 - Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals
JO - Regulatory Toxicology & Pharmacology: RTP
JF - Regulatory Toxicology & Pharmacology: RTP
Y1 - 2009/11//
VL - 55
IS - 2
M3 - Article
SP - 188
EP - 199
SN - 02732300
AB - Abstract: Three high-throughput screening (HTS) genotoxicity assays—GreenScreen HC GADD45a-GFP (Gentronix Ltd.), CellCiphr p53 (Cellumen Inc.) and CellSensor p53RE-bla (Invitrogen Corp.)—were used to analyze the collection of 320 predominantly pesticide active compounds being tested in Phase I of US. Environmental Protection Agency’s ToxCast™ research project. Between 9% and 12% of compounds were positive for genotoxicity in the assays. However, results of the varied tests only partially overlapped, suggesting a strategy of combining data from a battery of assays. The HTS results were compared to mutagenicity (Ames) and animal tumorigenicity data. Overall, the HTS assays demonstrated low sensitivity for rodent tumorigens, likely due to: screening at a low concentration, coverage of selected genotoxic mechanisms, lack of metabolic activation and difficulty detecting non-genotoxic carcinogens. Conversely, HTS results demonstrated high specificity, >88%. Overall concordance of the HTS assays with tumorigenicity data was low, around 50% for all tumorigens, but increased to 74–78% (vs. 60% for Ames) for those compounds producing tumors in rodents at multiple sites and, thus, more likely genotoxic carcinogens. The aim of the present study was to evaluate the utility of HTS assays to identify potential genotoxicity hazard in the larger context of the ToxCast project, to aid prioritization of environmentally relevant chemicals for further testing and assessment of carcinogenicity risk to humans. [Copyright &y& Elsevier]
AB - Copyright of Regulatory Toxicology & Pharmacology: RTP is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Genetic toxicology
KW - Biological assay
KW - Toxicity testing
KW - Pesticides
KW - Carcinogenesis
KW - High throughput screening (Drug development)
KW - Mutagenesis
KW - United States
KW - CellCiphr
KW - CellSensor
KW - GADD45 alpha
KW - Genotoxicity
KW - GreenScreen HC
KW - Hazard assessment
KW - High-throughput screening
KW - In vitro
KW - p53
KW - ToxCast
KW - United States. Environmental Protection Agency
N1 - Accession Number: 44484020; Knight, Andrew W. 1; Email Address: andrew.knight@gentronix.co.uk; Little, Stephen 2; Houck, Keith 2; Dix, David 2; Judson, Richard 2; Richard, Ann 2; McCarroll, Nancy 3; Akerman, Gregory 3; Yang, Chihae 4; Birrell, Louise 1; Walmsley, Richard M. 1; Affiliations: 1: Gentronix Ltd., CTF Building, 46 Grafton Street, Manchester, M13 9NT, UK; 2: National Center for Computational Toxicology (D343-03), Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA; 3: Health Effects Division, Office of Pesticide Programs, US Environmental Protection Agency, 1200 Pennsylvania Ave., NW (MC 7509P), Washington, DC 20460, USA; 4: Office of Food Additive Safety (HFS-275), Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA; Issue Info: Nov2009, Vol. 55 Issue 2, p188; Thesaurus Term: Genetic toxicology; Thesaurus Term: Biological assay; Thesaurus Term: Toxicity testing; Thesaurus Term: Pesticides; Thesaurus Term: Carcinogenesis; Subject Term: High throughput screening (Drug development); Subject Term: Mutagenesis; Subject: United States; Author-Supplied Keyword: CellCiphr; Author-Supplied Keyword: CellSensor; Author-Supplied Keyword: GADD45 alpha; Author-Supplied Keyword: Genotoxicity; Author-Supplied Keyword: GreenScreen HC; Author-Supplied Keyword: Hazard assessment; Author-Supplied Keyword: High-throughput screening; Author-Supplied Keyword: In vitro; Author-Supplied Keyword: p53; Author-Supplied Keyword: ToxCast ; Company/Entity: United States. Environmental Protection Agency; NAICS/Industry Codes: 325320 Pesticide and Other Agricultural Chemical Manufacturing; NAICS/Industry Codes: 424910 Farm Supplies Merchant Wholesalers; NAICS/Industry Codes: 924110 Administration of Air and Water Resource and Solid Waste Management Programs; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.yrtph.2009.07.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=44484020&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Latendresse, John R.
AU - Bucci, Thomas J.
AU - Olson, Greg
AU - Mellick, Paul
AU - Weis, Constance C.
AU - Thorn, Brett
AU - Newbold, Retha R.
AU - Delclos, K. Barry
T1 - Genistein and ethinyl estradiol dietary exposure in multigenerational and chronic studies induce similar proliferative lesions in mammary gland of male Sprague–Dawley rats
JO - Reproductive Toxicology
JF - Reproductive Toxicology
Y1 - 2009/11//
VL - 28
IS - 3
M3 - Article
SP - 342
EP - 353
SN - 08906238
AB - Abstract: Genistein and ethinyl estradiol (EE2) were examined in multigenerational reproductive and 2-yr chronic toxicity studies with different exposure durations across generations F0 through F4. Sprague–Dawley rats were exposed to genistein (0, 5, 100, or 500ppm) or EE2 (0, 2, 10, or 50ppb). Effects in the male mammary gland are described here. In the multigeneration studies, mammary hyperplasia was induced by both compounds; the chronic studies had a lower incidence, without proportionate neoplasia. Sexual dimorphism (predominant tubuloalveolar growth in females and lobuloalveolar in males) was retained without feminization in high dose genistein or EE2. In the continuously exposed generations, mammary hyperplasia was sustained but not amplified, appeared morphologically similar across all generations, and was not carried over into unexposed offspring of previously exposed generations. The hyperplasia in male rats was similar whether induced by genistein or EE2. Results substantiate and extend previous reports that mammary gland hyperplasia in the male rat is one of the most sensitive markers of estrogenic endocrine disruption. [Copyright &y& Elsevier]
AB - Copyright of Reproductive Toxicology is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ISOFLAVONES
KW - ETHINYL estradiol
KW - CHRONIC toxicity testing
KW - RATS as laboratory animals
KW - HYPERPLASIA
KW - SEXUAL dimorphism in animals
KW - MAMMARY glands -- Physiology
KW - MALES
KW - PHYSIOLOGY
KW - REPRODUCTIVE toxicology
KW - ENDOCRINE disruptors
KW - Endocrine disrupter
KW - Ethinyl estradiol
KW - Genistein
KW - Mammary gland toxicity
KW - Multigenerational
KW - Rat
KW - Reproductive toxicity
KW - Soy-free diet
N1 - Accession Number: 44828542; Latendresse, John R. 1; Email Address: john.latendresse@fda.hhs.gov Bucci, Thomas J. 1 Olson, Greg 1 Mellick, Paul 1 Weis, Constance C. 2 Thorn, Brett 2 Newbold, Retha R. 3 Delclos, K. Barry 2; Affiliation: 1: Toxicologic Pathology Associates, Jefferson, AR 72079, USA 2: National Center for Toxicological Research, Jefferson, AR 72079, USA 3: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Source Info: Nov2009, Vol. 28 Issue 3, p342; Subject Term: ISOFLAVONES; Subject Term: ETHINYL estradiol; Subject Term: CHRONIC toxicity testing; Subject Term: RATS as laboratory animals; Subject Term: HYPERPLASIA; Subject Term: SEXUAL dimorphism in animals; Subject Term: MAMMARY glands -- Physiology; Subject Term: MALES; Subject Term: PHYSIOLOGY; Subject Term: REPRODUCTIVE toxicology; Subject Term: ENDOCRINE disruptors; Author-Supplied Keyword: Endocrine disrupter; Author-Supplied Keyword: Ethinyl estradiol; Author-Supplied Keyword: Genistein; Author-Supplied Keyword: Mammary gland toxicity; Author-Supplied Keyword: Multigenerational; Author-Supplied Keyword: Rat; Author-Supplied Keyword: Reproductive toxicity; Author-Supplied Keyword: Soy-free diet; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.reprotox.2009.04.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44828542&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Bowyer, John F.
AU - Latendresse, John R.
AU - Delongchamp, Robert R.
AU - Warbritton, Alan R.
AU - Thomas, Monzy
AU - Divine, Becky
AU - Doerge, Daniel R.
T1 - The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/11//
VL - 240
IS - 3
M3 - Article
SP - 401
EP - 411
SN - 0041008X
AB - Abstract: A study was undertaken to determine whether alterations in the gene expression or overt histological signs of neurotoxicity in selected regions of the forebrain might occur from acrylamide exposure via drinking water. Gene expression at the mRNA level was evaluated by cDNA array and/or RT-PCR analysis in the striatum, substantia nigra and parietal cortex of rat after a 2-week acrylamide exposure. The highest dose tested (maximally tolerated) of approximately 44 mg/kg/day resulted in a significant decreased body weight, sluggishness, and locomotor activity reduction. These physiological effects were not accompanied by prominent changes in gene expression in the forebrain. All the expression changes seen in the 1200 genes that were evaluated in the three brain regions were ≤1.5-fold, and most not significant. Very few, if any, statistically significant changes were seen in mRNA levels of the more than 50 genes directly related to the cholinergic, noradrenergic, GABAergic or glutamatergic neurotransmitter systems in the striatum, substantia nigra or parietal cortex. All the expression changes observed in genes related to dopaminergic function were less than 1.5-fold and not statistically significant and the 5HT1b receptor was the only serotonin-related gene affected. Therefore, gene expression changes were few and modest in basal ganglia and sensory cortex at a time when the behavioral manifestations of acrylamide toxicity had become prominent. No histological evidence of axonal, dendritic or neuronal cell body damage was found in the forebrain due to the acrylamide exposure. As well, microglial activation was not present. These findings are consistent with the absence of expression changes in genes related to changes in neuroinflammation or neurotoxicity. Over all, these data suggest that oral ingestion of acrylamide in drinking water or food, even at maximally tolerable levels, induced neither marked changes in gene expression nor neurotoxicity in the motor and somatosensory areas of the central nervous system. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NEUROTOXICOLOGY
KW - ACRYLAMIDE
KW - MESSENGER RNA
KW - GENE expression
KW - PROSENCEPHALON
KW - RATS as laboratory animals
KW - DOPAMINE
KW - HISTOLOGY
KW - AFFERENT pathways
KW - CONTAMINATION of drinking water
KW - BASAL ganglia
KW - Acrylamide
KW - Basal ganglia
KW - Dopamine
KW - Gene expression
KW - Neurotoxicity
N1 - Accession Number: 44578045; Bowyer, John F. 1; Email Address: john.bowyer@fda.hhs.gov Latendresse, John R. 2 Delongchamp, Robert R. 3 Warbritton, Alan R. 2 Thomas, Monzy 1 Divine, Becky 2 Doerge, Daniel R. 4; Affiliation: 1: US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, USA 2: Toxicologic Pathology Associates, 3900 NCTR Road, Jefferson, AR 72079, USA 3: Department of Epidemiolgoy, University of Arkansas for Medical Sciences, College of Public Health, 4301 W. Markham St., #820, Little Rock, AR 72205, USA 4: US Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Nov2009, Vol. 240 Issue 3, p401; Subject Term: NEUROTOXICOLOGY; Subject Term: ACRYLAMIDE; Subject Term: MESSENGER RNA; Subject Term: GENE expression; Subject Term: PROSENCEPHALON; Subject Term: RATS as laboratory animals; Subject Term: DOPAMINE; Subject Term: HISTOLOGY; Subject Term: AFFERENT pathways; Subject Term: CONTAMINATION of drinking water; Subject Term: BASAL ganglia; Author-Supplied Keyword: Acrylamide; Author-Supplied Keyword: Basal ganglia; Author-Supplied Keyword: Dopamine; Author-Supplied Keyword: Gene expression; Author-Supplied Keyword: Neurotoxicity; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.taap.2009.07.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44578045&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - RPRT
AU - MacPherson, Jim
AU - Kochman, Sheryl
AU - McCullough, Jeffrey
T1 - Regulating blood manufacturing software: report of a conference.
JO - Transfusion
JF - Transfusion
Y1 - 2009/11//
VL - 49
IS - 11
M3 - Report
SP - 2490
EP - 2494
PB - Wiley-Blackwell
SN - 00411132
AB - The article presents information on the July 2008 conference titled "Blood Establishment Computer Software (BECS) Conference." It was made clear by the conference that there is no easy solution to the unintended consequences of BECS regulation in the U.S. At the conference, there was general agreement that 510(k) regulation indeed improves the quality of the BECS, at least to the extent that both user manuals and documentation have improved.
KW - BLOOD
KW - COMPUTER software -- Congresses
KW - CONFERENCES & conventions
KW - TECHNICAL manuals
KW - CONGRESSES
KW - UNITED States
N1 - Accession Number: 44758152; MacPherson, Jim 1,2 Kochman, Sheryl 1,2 McCullough, Jeffrey 1,2; Email Address: mccul001@umn.edu; Affiliation: 1: America's Blood Centers,Washington, DC; the American Red Cross and Institute for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota. 2: Division of Blood Applications, Office of Blood Research and Review, Food and Drug Administration, Rockville, Maryland.; Source Info: Nov2009, Vol. 49 Issue 11, p2490; Subject Term: BLOOD; Subject Term: COMPUTER software -- Congresses; Subject Term: CONFERENCES & conventions; Subject Term: TECHNICAL manuals; Subject Term: CONGRESSES; Subject Term: UNITED States; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; NAICS/Industry Codes: 323119 Other printing; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; NAICS/Industry Codes: 443144 Computer and software stores; Number of Pages: 5p; Document Type: Report
L3 - 10.1111/j.1537-2995.2009.02287.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44758152&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105242660
T1 - Regulating blood manufacturing software: report of a conference.
AU - Macpherson J
AU - Kochman S
AU - McCullough J
Y1 - 2009/11//
N1 - Accession Number: 105242660. Language: English. Entry Date: 20100528. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Blood Banks -- Legislation and Jurisprudence
KW - Congresses and Conferences
KW - Software
KW - United States
KW - United States Food and Drug Administration
SP - 2490
EP - 2494
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 11
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - From America's Blood Centers, Washington, DC; the American Red Cross and the Institute for Engineering in Medicine, University of Minnesota, Minneapolis, Minnesota; and the Division of Blood Applications, Office of Blood Research and Review, Food and Drug Administration, Rockville, Maryland.
U2 - PMID: 19903297.
DO - 10.1111/j.1537-2995.2009.02287.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105242660&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105232445
T1 - Gender differences in correlates of troponin assay in diagnosis of myocardial infarction.
AU - Shoaibi A
AU - Tavris DR
AU - McNulty S
Y1 - 2009/11//
N1 - Accession Number: 105232445. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 101280339.
KW - Myocardial Infarction -- Diagnosis
KW - Troponin -- Blood
KW - Biological Markers -- Blood
KW - Chest Pain
KW - Diagnosis, Differential
KW - Electrocardiography
KW - Female
KW - Heart Failure -- Blood
KW - Heart Failure -- Diagnosis
KW - Human
KW - Male
KW - Myocardial Infarction -- Blood
KW - Myocardial Infarction -- Physiopathology
KW - Predictive Value of Tests
KW - Prospective Studies
KW - Renal Insufficiency -- Blood
KW - Renal Insufficiency -- Diagnosis
KW - Reproducibility of Results
KW - Sex Factors
SP - 250
EP - 256
JO - Translational Research: The Journal of Laboratory & Clinical Medicine
JF - Translational Research: The Journal of Laboratory & Clinical Medicine
JA - TRANSL RES
VL - 154
IS - 5
CY - New York, New York
PB - Elsevier Science
AB - Cardiac troponins are the most sensitive and specific biomarker for myocardial infarction (MI) diagnosis. If there is a gender bias in MI diagnosis, it could be reduced by more consistently applying objective diagnostic criteria to improve women's outcomes. This study set out to assess the accuracy and correlates of the cardiac troponin I (cTnI) assay in the diagnosis of non-ST-segment elevation MI, to determine how the assay accuracy and correlates vary by gender, and to explore the interaction between factors that may influence cTnI accuracy and affect gender differences in diagnosis. The data were obtained from the CHECKMATE study. It included 924 patients with possible myocardial ischemia excluding subjects with ST-segment elevation. The Dade-Behring Stratus CS STAT near-patient instrument (Dade Behring, Inc, Newark, Del) was used to measure cTnI. We assessed baseline troponin accuracy using a standard MI definition. There were 125 subjects with a definite MI diagnosis. Baseline troponin was 44% sensitive and 97% specific in predicting MI, with no significant gender differences. In contrast, other positive cardiac markers, namely rising or falling creatine-kinase MB fraction and positive electrocardiogram, occurred more frequently in men. Sensitivity (SE) of baseline troponin was higher in subjects where baseline troponin was obtained longer than 2hours after the chest pain onset. The study did not observe a significant difference in the assay SE or specificity by gender. This observation, plus the fact that other positive cardiac markers occurred more frequently in men, suggest the troponin test may help to improve the diagnosis of MI in women.
SN - 1931-5244
AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD.
U2 - PMID: 19840766.
DO - 10.1016/j.trsl.2009.07.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105232445&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Clancy, Carolyn M.
T1 - Tools to Alleviate Safety Concerns.
JO - Trustee
JF - Trustee
Y1 - 2009/11//Nov/Dec2009
VL - 62
IS - 10
M3 - Article
SP - 30
EP - 32
PB - Health Forum
SN - 00413674
AB - The article provides information on various tools essential for fostering a culture of safety in healthcare in the U.S. Since the report "To Err Is Human: Building a Safer Health System" was released by the Institute of Medicine, hospitals have worked diligently to reduce medical errors. Tools for safety launched by the Agency for Healthcare Research and Quality such as Hospital Consumer Assessment of Healthcare Providers and Systems and Inpatient Quality Indicators are discussed.
KW - MEDICAL care
KW - HOSPITALS
KW - MEDICAL errors
KW - UNITED States
KW - INSTITUTE of Medicine (U.S.)
N1 - Accession Number: 45583143; Clancy, Carolyn M. 1; Affiliations: 1: Director, Agency for Healthcare Research and Quality, Rockville, Md.; Issue Info: Nov/Dec2009, Vol. 62 Issue 10, p30; Thesaurus Term: MEDICAL care; Thesaurus Term: HOSPITALS; Subject Term: MEDICAL errors; Subject: UNITED States ; Company/Entity: INSTITUTE of Medicine (U.S.); NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 3p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=45583143&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105271003
T1 - Tools to alleviate safety concerns.
AU - Clancy CM
Y1 - 2009/11//Nov/Dec2009
N1 - Accession Number: 105271003. Language: English. Entry Date: 20100129. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Health Services Administration; USA. NLM UID: 21330020R.
KW - Health Facility Administration
KW - Quality Assurance -- Methods
KW - Safety
KW - Treatment Errors -- Prevention and Control
KW - United States
SP - 30
EP - 2
JO - Trustee
JF - Trustee
JA - TRUSTEE
VL - 62
IS - 10
CY - Chicago, Illinois
PB - Health Forum
SN - 0041-3674
AD - Agency for Healthcare Research and Quality, Rockville, MD, USA
U2 - PMID: 19998605.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105271003&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ray, G. Thomas
AU - Pelton, Stephen I.
AU - Klugman, Keith P.
AU - Strutton, David R.
AU - Moore, Matthew R.
T1 - Cost-effectiveness of pneumococcal conjugate vaccine: An update after 7 years of use in the United States
JO - Vaccine
JF - Vaccine
Y1 - 2009/11//
VL - 27
IS - 47
M3 - Article
SP - 6483
EP - 6494
SN - 0264410X
AB - Abstract: Seven-valent pneumococcal conjugate vaccine (PCV7) has been in routine use in the United States since 2000 and data have indicated direct and indirect effects of the vaccine. We simulated the effects of PCV7 on children vaccinated during 2000–2006, incorporating direct and indirect effects on incidence of invasive pneumococcal disease (IPD), hospitalized pneumonia and otitis media. Before accounting for indirect effects, PCV7 cost $201,000 per life-year saved. After incorporating indirect effects on IPD, cost per life-year saved was $10,400. The presence of modest additional indirect effects against hospitalized pneumonia and otitis media in children may have resulted in overall cost savings. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cost effectiveness
KW - Bacterial diseases
KW - Pneumococcal vaccine
KW - Drugs -- Physiological effect
KW - Vaccination of children
KW - Children -- Hospital care
KW - Pneumonia in children
KW - United States
KW - Cost
KW - Herd immunity
KW - Pneumococcal conjugate vaccine
KW - Pneumococcus
KW - Vaccine
N1 - Accession Number: 45001970; Ray, G. Thomas 1; Email Address: tom.ray@kp.org; Pelton, Stephen I. 2; Klugman, Keith P. 3; Strutton, David R. 4; Moore, Matthew R. 5,6; Affiliations: 1: Division of Research, Kaiser Permanente Medical Care Program (Northern California Region), 2000 Broadway, Oakland, CA 94612, United States; 2: Department of Pediatrics, Boston University School of Medicine, Boston, MA, United States; 3: Hubert Department of Global Health, Rollins School of Public Health and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA, United States; 4: Wyeth Research, Philadelphia, PA, United States; 5: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; 6: U.S. Public Health Service, United States; Issue Info: Nov2009, Vol. 27 Issue 47, p6483; Thesaurus Term: Cost effectiveness; Thesaurus Term: Bacterial diseases; Subject Term: Pneumococcal vaccine; Subject Term: Drugs -- Physiological effect; Subject Term: Vaccination of children; Subject Term: Children -- Hospital care; Subject Term: Pneumonia in children; Subject: United States; Author-Supplied Keyword: Cost; Author-Supplied Keyword: Herd immunity; Author-Supplied Keyword: Pneumococcal conjugate vaccine; Author-Supplied Keyword: Pneumococcus; Author-Supplied Keyword: Vaccine; Number of Pages: 12p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.08.045
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45001970&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Price, Graeme E.
AU - Soboleski, Mark R.
AU - Lo, Chia-Yun
AU - Misplon, Julia A.
AU - Pappas, Claudia
AU - Houser, Katherine V.
AU - Tumpey, Terrence M.
AU - Epstein, Suzanne L.
T1 - Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses
JO - Vaccine
JF - Vaccine
Y1 - 2009/11//
VL - 27
IS - 47
M3 - Article
SP - 6512
EP - 6521
SN - 0264410X
AB - Abstract: Immunization against conserved virus components induces broad, heterosubtypic protection against diverse influenza A viruses, providing a strategy for controlling unexpected outbreaks or pandemics until strain-matched vaccines become available. This study characterized immunization to nucleoprotein (NP) and matrix 2 (M2) by DNA priming followed by parenteral or mucosal boosting in mice and ferrets. DNA vaccination followed by boosting with antigen-matched recombinant adenovirus (rAd) or cold-adapted (ca) influenza virus provided robust protection against virulent H1N1 and H5N1 challenges. Compared to other boosts, mucosal rAd induced stronger IgA responses, more virus-specific activated T-cells in the lung, and better protection against morbidity following challenge even eight months post-boost. In ferrets, both mucosal and parenteral rAd boosting protected from lethal H5N1 challenge. These findings demonstrate potent protection by vaccination highly focused on conserved antigens and identify immune response measures in mice that differed among vaccinations and correlated with outcome. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Virulence (Microbiology)
KW - Antigens
KW - Immune response
KW - VACCINATION
KW - Influenza A virus, H1N1 subtype
KW - Influenza A virus, H5N1 subtype
KW - Mice as laboratory animals
KW - Ferrets as laboratory animals
KW - Influenza
KW - Nucleoproteins
KW - Cold-adapted
KW - DNA vaccine
KW - Ferret
KW - H5N1
KW - Heterosubtypic immunity
KW - Immunization
KW - Influenza
KW - Intramuscular
KW - Intranasal
KW - Mice
KW - Pandemic
KW - Prime-boost
KW - Recombinant adenovirus
KW - Systemic
KW - Vaccine
N1 - Accession Number: 45001973; Price, Graeme E. 1; Soboleski, Mark R. 1; Lo, Chia-Yun 1; Misplon, Julia A. 1; Pappas, Claudia 2; Houser, Katherine V. 2; Tumpey, Terrence M. 2; Epstein, Suzanne L. 1; Email Address: suzanne.epstein@fda.hhs.gov; Affiliations: 1: Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA; 2: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta GA 30333, USA; Issue Info: Nov2009, Vol. 27 Issue 47, p6512; Thesaurus Term: Virulence (Microbiology); Thesaurus Term: Antigens; Thesaurus Term: Immune response; Thesaurus Term: VACCINATION; Subject Term: Influenza A virus, H1N1 subtype; Subject Term: Influenza A virus, H5N1 subtype; Subject Term: Mice as laboratory animals; Subject Term: Ferrets as laboratory animals; Subject Term: Influenza; Subject Term: Nucleoproteins; Author-Supplied Keyword: Cold-adapted; Author-Supplied Keyword: DNA vaccine; Author-Supplied Keyword: Ferret; Author-Supplied Keyword: H5N1; Author-Supplied Keyword: Heterosubtypic immunity; Author-Supplied Keyword: Immunization; Author-Supplied Keyword: Influenza; Author-Supplied Keyword: Intramuscular; Author-Supplied Keyword: Intranasal; Author-Supplied Keyword: Mice; Author-Supplied Keyword: Pandemic; Author-Supplied Keyword: Prime-boost; Author-Supplied Keyword: Recombinant adenovirus; Author-Supplied Keyword: Systemic; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.08.053
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45001973&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Erickson, Pennifer
AU - Willke, Richard
AU - Burke, Laurie
T1 - A Concept Taxonomy and an Instrument Hierarchy: Tools for Establishing and Evaluating the Conceptual Framework of a Patient-Reported Outcome (PRO) Instrument as Applied to Product Labeling Claims.
JO - Value in Health
JF - Value in Health
Y1 - 2009/11//Nov/Dec2009
VL - 12
IS - 8
M3 - Article
SP - 1158
EP - 1167
PB - Elsevier Science
SN - 15244733
AB - Objective: To facilitate development and evaluation of a PRO instrument conceptual framework, we propose two tools—a PRO concept taxonomy and a PRO instrument hierarchy. FDA's draft guidance on patient reported outcome (PRO) measures states that a clear description of the conceptual framework of an instrument is useful for evaluating its adequacy to support a treatment benefit claim for use in product labeling the draft guidance, however does not propose tools for establishing or evaluationg a PRO instrument's conceptual framework. Methods: We draw from our review of PRO concepts and instruments that appear in prescription drug labeling approved in the United States from 1997 to 2007. Results: We propose taxonomy terms that define relationships between PRO concepts, including “family,”“compound concept,” and “singular concept.” Based on the range of complexity represented by the concepts, as defined by the taxonomy, we propose nine instrument orders for PRO measurement. The nine orders range from individual event counts to multiitem, multiscale instruments. Conclusion: This analysis of PRO concepts and instruments illustrates that the taxonomy and hierarchy are applicable to PRO concepts across a wide range of therapeutic areas and provide a basis for defining the instrument conceptual framework complexity. Although the utility of these tools in the drug development, review, and approval processes has not yet been demonstrated, these tools could be useful to improve communication and enhance efficiency in the instrument development and review process. [ABSTRACT FROM AUTHOR]
AB - Copyright of Value in Health is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OUTCOME assessment (Medical care)
KW - MEDICAL care -- United States
KW - DRUG development
KW - TAXONOMY
KW - UNITED States
KW - classification system
KW - conceptual framework
KW - patient-reported outcomes
KW - PRO concept taxonomy
KW - PRO instrument hierarchy
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 44985181; Erickson, Pennifer 1; Email Address: pae6@psu.edu Willke, Richard 2 Burke, Laurie 3; Affiliation: 1: OLGA, State College, PA, USA. 2: Global Outcomes Research, Pfizer Inc., Peapack, NJ, USA. 3: Study Endpoints and Labeling, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.; Source Info: Nov/Dec2009, Vol. 12 Issue 8, p1158; Subject Term: OUTCOME assessment (Medical care); Subject Term: MEDICAL care -- United States; Subject Term: DRUG development; Subject Term: TAXONOMY; Subject Term: UNITED States; Author-Supplied Keyword: classification system; Author-Supplied Keyword: conceptual framework; Author-Supplied Keyword: patient-reported outcomes; Author-Supplied Keyword: PRO concept taxonomy; Author-Supplied Keyword: PRO instrument hierarchy; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 10p; Illustrations: 4 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1524-4733.2009.00609.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44985181&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-18834-002
AN - 2009-18834-002
AU - Krieg, Edward F. Jr.
AU - Butler, Mary Ann
AU - Chang, Man-huei
AU - Liu, Tiebin
AU - Yesupriya, Ajay
AU - Lindegren, Mary Lou
AU - Dowling, Nicole
T1 - Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.
JF - Neurotoxicology and Teratology
JO - Neurotoxicology and Teratology
JA - Neurotoxicol Teratol
Y1 - 2009/11//Nov-Dec, 2009
VL - 31
IS - 6
SP - 364
EP - 371
CY - Netherlands
PB - Elsevier Science
SN - 0892-0362
SN - 1872-9738
AD - Krieg, Edward F. Jr., National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH, US, 45226
N1 - Accession Number: 2009-18834-002. PMID: 19686844 Other Journal Title: Neurobehavioral Toxicology & Teratology. Partial author list: First Author & Affiliation: Krieg, Edward F. Jr.; National Institute for Occupational Safety and Health, Cincinnati, OH, US. Release Date: 20091109. Correction Date: 20161128. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Cognitive Ability; Genotypes; Lead (Metal). Minor Descriptor: Blood; Cysteine; Neurotoxicity. Classification: Environmental Toxins & Health (3280). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380); Very Old (85 yrs & older) (390). Tests & Measures: Wechsler Intelligence Scale for Children- Revised, block design; Wechsler Intelligence Scale for Children- Revised, digit span; Wide Range Achievement Test-Revised, reading; Wide Range Achievement Test-Revised, arithmetic; Neurobehavioral Evaluation System 2. Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Nov-Dec, 2009. Publication History: First Posted Date: Aug 15, 2009; Accepted Date: Aug 7, 2009; Revised Date: Jul 23, 2009; First Submitted Date: Nov 13, 2008.
AB - The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - blood lead
KW - cognitive function
KW - ALAD genotypes
KW - homocysteine
KW - National Health and Nutrition Examination Survey III
KW - 2009
KW - Cognitive Ability
KW - Genotypes
KW - Lead (Metal)
KW - Blood
KW - Cysteine
KW - Neurotoxicity
KW - 2009
DO - 10.1016/j.ntt.2009.08.003
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-18834-002&site=ehost-live&scope=site
UR - erk3@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-03095-003
AN - 2010-03095-003
AU - Zhu, Judy
AU - Xu, Wenjing
AU - Wang, Jing
AU - Ali, Syed F.
AU - Angulo, Jesus A.
T1 - The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.
JF - Journal of Neurochemistry
JO - Journal of Neurochemistry
JA - J Neurochem
Y1 - 2009/11//
VL - 111
IS - 3
SP - 656
EP - 668
CY - United Kingdom
PB - Wiley-Blackwell Publishing Ltd.
SN - 0022-3042
SN - 1471-4159
AD - Angulo, Jesus A., Department of Biological Sciences, Hunter College, 695 Park Avenue, New York, NY, US, 10021
N1 - Accession Number: 2010-03095-003. PMID: 19682209 Partial author list: First Author & Affiliation: Zhu, Judy; Department of Biological Sciences, Hunter College, City University of New York, New York, NY, US. Release Date: 20100503. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Angulo, Jesus A. Major Descriptor: Injections; Methamphetamine; Neurokinins; Nitric Oxide. Minor Descriptor: Apoptosis; Mice; Neural Receptors; Striatum. Classification: Psychopharmacology (2580). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 13. Issue Publication Date: Nov, 2009. Publication History: Accepted Date: Jul 27, 2009; Revised Date: Jul 20, 2009; First Submitted Date: May 8, 2009. Copyright Statement: The Authors. Journal Compilation—International Society for Neurochemistry. 2009.
AB - In a previous study we showed that pharmacological blockade of the neurokinin-1 receptors attenuated the methamphetamine (METH)-induced toxicity of the striatal dopamine terminals. In the present study we examined the role of the neurokinin-1 receptors on the METH-induced apoptosis of some striatal neurons. To that end, we administered a single injection of METH (30 mg/kg, i.p.) to male mice. METH induced the apoptosis (terminal deoxyncleotidyl transferase-mediated dUTP nick end labeling) of approximately 20% of striatal neurons. This percentage of METH-induced apoptosis was significantly attenuated by either a single injection of the neurokinin-1 receptor antagonist, 17-β-hydroxy-17-a-ethynyl-5-a-androstano[3,2-β]pyrimido[1,2-a]benzimidazole (WIN-51,708) (5 mg/kg, i.p.), or the ablation of the striatal interneurons expressing the neurokinin-1 receptors (cholinergic and somatostatin) with the selective neurotoxin [Sar⁹,Met(O₂)¹¹] substance P-saporin. Next we assessed the levels of striatal 3-nitrotyrosine (3-NT) by HPLC and immunohistochemistry. METH increased the levels of striatal 3-NT and this increase was attenuated by pre-treatment with WIN-51,708. Our data support the hypothesis that METH-induced striatal apoptosis occurs via a mechanism involving the neurokinin-1 receptors and the activation of nitric oxide synthesis. Our findings are relevant for the treatment of METH abuse and may be relevant to certain neurological disorders involving the dopaminergic circuitry of the basal ganglia. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - neurokinin-1 receptors
KW - methamphetamine
KW - striatal apoptosis
KW - nitric oxide
KW - mice
KW - injections
KW - 2009
KW - Injections
KW - Methamphetamine
KW - Neurokinins
KW - Nitric Oxide
KW - Apoptosis
KW - Mice
KW - Neural Receptors
KW - Striatum
KW - 2009
U1 - Sponsor: National Institute on Drug Abuse, US. Grant: R01 DA020142. Recipients: Angulo, Jesus A.
U1 - Sponsor: National Institutes of Health, National Center for Research Resources, US. Other Details: Hunter College. Recipients: No recipient indicated
DO - 10.1111/j.1471-4159.2009.06330.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-03095-003&site=ehost-live&scope=site
UR - Angulo@genectr.hunter.cuny.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-17763-015
AN - 2009-17763-015
AU - Zou, Xiaoju
AU - Patterson, Tucker A.
AU - Divine, Rebecca L.
AU - Sadovova, Natalya
AU - Zhang, Xuan
AU - Hanig, Joseph P.
AU - Paule, Merle G.
AU - Slikker, William Jr.
AU - Wang, Cheng
T1 - Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain.
JF - International Journal of Developmental Neuroscience
JO - International Journal of Developmental Neuroscience
JA - Int J Dev Neurosci
Y1 - 2009/11//
VL - 27
IS - 7
SP - 727
EP - 731
CY - Netherlands
PB - Elsevier Science
SN - 0736-5748
AD - Wang, Cheng, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, US, 72079-9502
N1 - Accession Number: 2009-17763-015. PMID: 19580862 Partial author list: First Author & Affiliation: Zou, Xiaoju; Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR, US. Release Date: 20091012. Correction Date: 20120618. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Animal Development; Ketamine; Neurotoxicity; Neurodegeneration; Neuropharmacology. Minor Descriptor: Brain Development; Drug Therapy; Monkeys; Stimulus Duration. Classification: Psychopharmacology (2580). Population: Animal (20). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 5. Issue Publication Date: Nov, 2009. Publication History: Accepted Date: Jun 26, 2009; Revised Date: Jun 12, 2009; First Submitted Date: May 18, 2009.
AB - Ketamine, a widely used pediatric anesthetic, has been associated with enhanced neuronal toxicity in the developing brain, but mechanisms and neuronal susceptibility to neurotoxic insult leading to neuronal cell death remain poorly defined. One of the main goals of this study was to determine whether there is a duration of ketamine-induced anesthesia below which no significant ketamine-induced neurodegeneration can be detected. Newborn rhesus monkeys (postnatal day 5 or 6) were administered ketamine intravenously for 3, 9 or 24 h to maintain a steady anesthetic plane, followed by a 6-h withdrawal period. The 9- and 24-h durations were selected as relatively long and extremely long exposures, respectively, while the 3-h treatment more closely approximates a typical duration of pediatric general anesthesia. Animals were subsequently perfused under anesthesia and brain tissue was processed for analyses using silver and Fluoro-Jade C stains and caspase-3 immunostain. The results indicated that no significant neurotoxic effects occurred if the anesthesia duration was 3 h. However, ketamine infusions for either 9 or 24 h significantly increased neuronal cell death in layers II and III of the frontal cortex. Although a few caspase-3- and Fluoro-Jade C-positive neuronal profiles were observed in some additional brain areas including the hippocampus, thalamus, striatum and amygdala, no significant differences were detected between ketamine-treated and control monkeys in these areas after 3, 9 or 24 h of exposure. These data show that treatment with ketamine up to 3 h is without adverse effects as determined by nerve cell death. However, anesthetic durations of 9 h or greater are associated with significant brain cell death in the frontal cortex. Thus, the threshold duration below which no neurotoxicity would be expected is somewhere between 3 and 9h. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - ketamine
KW - NMDA receptor antagonist
KW - neurotoxicity
KW - monkeys
KW - exposure duration
KW - 2009
KW - Animal Development
KW - Ketamine
KW - Neurotoxicity
KW - Neurodegeneration
KW - Neuropharmacology
KW - Brain Development
KW - Drug Therapy
KW - Monkeys
KW - Stimulus Duration
KW - 2009
U1 - Sponsor: US Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), Center for Drug Evaluation and Research (CDER), US. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Child Health and Human Development, US. Recipients: No recipient indicated
DO - 10.1016/j.ijdevneu.2009.06.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-17763-015&site=ehost-live&scope=site
UR - cheng.wang@fda.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2011-13143-001
AN - 2011-13143-001
AU - Matthieu, Monica M.
AU - Chen, Yufei
AU - Schohn, Mary
AU - Lantinga, Larry J.
AU - Knox, Kerry L.
T1 - Educational preferences and outcomes from suicide prevention training in the veterans health administration: One-year follow-up with healthcare employees in upstate New York.
JF - Military Medicine
JO - Military Medicine
JA - Mil Med
Y1 - 2009/11//
VL - 174
IS - 11
SP - 1123
EP - 1131
CY - US
PB - Assn of Military Surgeons of the US
SN - 0026-4075
SN - 1930-613X
AD - Matthieu, Monica M., Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, One Brookings Drive, Campus Box 1196, St. Louis, MO, US, 63130
N1 - Accession Number: 2011-13143-001. PMID: 19960817 Partial author list: First Author & Affiliation: Matthieu, Monica M.; Washington University, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO, US. Release Date: 20110926. Correction Date: 20170302. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Conference Information: Department of Veterans Affairs 2007 conference titled Transforming Mental Health Care: Promoting Recovery and Integrated Care, 2007, Alexandria, VA, US. Grant Information: Matthieu, Monica M. Conference Note: Preliminary data from this study was presented at the aforementioned conference. Major Descriptor: Health Care Services; Military Veterans; Personnel; Suicide Prevention; Training. Classification: Professional Education & Training (3410); Military Psychology (3800). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Tests & Measures: Peer Observational Checklist; Role Play Acceptability Scale. Methodology: Empirical Study; Followup Study; Longitudinal Study; Interview; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2009. Copyright Statement: All rights reserved. Association of Military Surgeons of the U.S.
AB - This study identifies training outcomes and educational preferences of employees who work within the Veterans Health Administration (VHA). Using a longitudinal pre-postsurvey design, 71 employees from one geographic region of VHA healthcare facilities participated in an evaluation of a brief standardized gatekeeper program and a needs assessment on training preferences for suicide and suicide prevention. Results indicate significant differences in knowledge and self-efficacy from pre to post ( p < 0.001), although only self-efficacy remained significant at 1 year follow-up, ( M = 3.01; SD = 0.87) as compared to pretraining ( M = 2.50, SD = 1.05) ( t = −5.64, p < 0.001). At post-training, 90% of the participants were willing to learn more about suicide, with 88% willing to spend more than 1 hour in future training activities on more advanced topics. This training program can increase the knowledge and abilities of VHA staff to engage, identify, and refer veterans at risk for suicide to appropriate care. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - educational preferences
KW - suicide prevention training
KW - Veterans Health Administration
KW - health care employees
KW - New York
KW - health care facilities
KW - 2009
KW - Health Care Services
KW - Military Veterans
KW - Personnel
KW - Suicide Prevention
KW - Training
KW - 2009
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH020061. Other Details: Institutional T32 grant. Recipients: Matthieu, Monica M.; Conwell (Prin Inv)
U1 - Sponsor: National Institute of Mental Health, US. Grant: MH071897. Other Details: P20 Developing Center for Public Health and Population-Based Approaches to Suicide Prevention. Recipients: Caine (Prin Inv)
U1 - Sponsor: National Institute of Mental Health, US. Grant: K01; MH055317. Recipients: Knox, Kerry L.
U1 - Sponsor: Syracuse VA Center for Integrated Healthcare. Recipients: Schohn, Mary
U1 - Sponsor: VISN 2 Center of Excellence for Drs. Recipients: No recipient indicated
DO - 10.7205/MILMED-D-00-1109
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2011-13143-001&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-01268-015
AN - 2010-01268-015
AU - Kogan, Michael D.
AU - Blumberg, Stephen J.
AU - Schieve, Laura A.
AU - Boyle, Coleen A.
AU - Perrin, James M.
AU - Ghandour, Reem M.
AU - Singh, Gopal K.
AU - Strickland, Bonnie B.
AU - Trevathan, Edwin
AU - van Dyck, Peter C.
T1 - Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/11//
VL - 124
IS - 5
SP - 1395
EP - 1403
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Kogan, Michael D., Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2010-01268-015. PMID: 19805460 Partial author list: First Author & Affiliation: Kogan, Michael D.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20100531. Correction Date: 20151207. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Grant Information: Perrin, James M. Major Descriptor: Autism Spectrum Disorders; Parents. Minor Descriptor: Diagnosis; Family; Parent Report. Classification: Developmental Disorders & Autism (3250). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200); Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Nov, 2009. Publication History: Accepted Date: Aug 3, 2009. Copyright Statement: American Academy of Pediatrics. 2009.
AB - Objectives: The reported increasing prevalence of autism spectrum disorder (ASD) and attendant health and family impact make monitoring of ASD prevalence a public health priority. Methods: The prevalence of parent-reported diagnosis of ASD among US children aged 3 to 17 years was estimated from the 2007 National Survey of Children's Health (sample size: 78037). A child was considered to have ASD if a parent/guardian reported that a doctor or other health care provider had ever said that the child had ASD and that the child currently had the condition. The point-prevalence for ASD was calculated for those children meeting both criteria. We examined sociodemographic factors associated with current ASD and with a past (but not current) ASD diagnosis. The health care experiences for children in both ASD groups were explored. Results: The weighted current ASD point-prevalence was 110 per 10,000. We estimate that 673,000 US children have ASD. Odds of having ASD were 4 times as large for boys than girls. Non-Hispanic (NH) black and multiracial children had lower odds of ASD than NH white children. Nearly 40% of those ever diagnosed with ASD did not currently have the condition; NH black children were more likely than NH white children to not have current ASD. Children in both ASD groups were less likely than children without ASD to receive care within a medical home. Conclusions: The observed point-prevalence is higher than previous US estimates. More inclusive survey questions, increased population awareness, and improved screening and identification by providers may partly explain this finding. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - parent–reported diagnosis
KW - autism spectrum disorder
KW - children
KW - US
KW - family impacts
KW - 2009
KW - Autism Spectrum Disorders
KW - Parents
KW - Diagnosis
KW - Family
KW - Parent Report
KW - 2009
U1 - Sponsor: Autism Speaks. Recipients: Perrin, James M.
U1 - Sponsor: Health Resources and Services Administration, Maternal and Child Health Bureau. Grant: UA3 MC 11054. Other Details: Cooperative agreement. Recipients: Perrin, James M.
DO - 10.1542/peds.2009-1522
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-01268-015&site=ehost-live&scope=site
UR - mkogan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-22795-015
AN - 2009-22795-015
AU - Wittey, Joshua Z.
AU - Xu, Qiang
AU - Boden-Albal, Bernadette
AU - Paik, Myunghee C.
AU - Moon, Yeseon Park
AU - Sacco, Ralph L.
AU - Elkind, Mitchell S. V.
T1 - Lipid profile components and risk ischemic stroke: The Northern Manhattan Study (NOMAS).
JF - Archives of Neurology
JO - Archives of Neurology
JA - Arch Neurol
Y1 - 2009/11//
VL - 66
IS - 11
SP - 1400
EP - 1406
CY - US
PB - American Medical Association
SN - 0003-9942
SN - 1538-3687
AD - Elkind, Mitchell S. V., Neurological Institute, 710 W 168th St, New York, NY, US, 10032
N1 - Accession Number: 2009-22795-015. Other Journal Title: A.M.A. Archives of Neurology; JAMA Neurology. Partial author list: First Author & Affiliation: Wittey, Joshua Z.; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, US. Release Date: 20100412. Correction Date: 20130121. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Cerebral Ischemia; Cerebrovascular Accidents; Cholesterol; Lipids; Risk Factors. Classification: Cardiovascular Disorders (3295). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300); Aged (65 yrs & older) (380). Methodology: Empirical Study; Longitudinal Study; Prospective Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Nov, 2009. Publication History: Accepted Date: Apr 21, 2009.
AB - Objective: To explore the relationship between lipid profile components and incident ischemic stroke in a stroke-free prospective cohort. Design: Population-based prospective cohort study. Setting: Northern Manhattan, New York. Patients: Stroke-free community residents. Intervention: As part of the Northern Manhattan Study, baseline fasting blood samples were collected on stroke-free community residents followed up for a mean of 7.5 years. Main Outcome Measures: Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals for lipid profile components and ischemic stroke after adjusting for demographic and risk factors. In secondary analyses, we used repeated lipid measures over 5 years from a 10% sample of the population to calculate the change per year of each of the lipid parameters and to impute time-dependent lipid parameters for the full cohort. Results: After excluding those with a history of myocardial infarction, 2940 participants were available for analysis. Baseline high-density lipoprotein cholesterol, triglyceride, and total cholesterol levels were not associated with risk of ischemic stroke. Low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol levels were associated with a paradoxical reduction in risk of stroke. There was an interaction with use of cholesterol-lowering medication on follow-up, such that LDL-C level was only associated with a reduction in stroke risk among those taking medications. An LDL-C level greater than 130 mg/dL as a time-dependent covariate showed an increased risk of ischemic stroke (adjusted hazard ratio, 3.81; 95% confidence interval, 1.53-9.51). Conclusions: Baseline lipid panel components were not associated with an increased stroke risk in this cohort. Treatment with cholesterol-lowering medications and changes in LDL-C level over time may have attenuated the risk in this population, and lipid measurements at several points may be a better marker of stroke risk. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - lipids
KW - risk factors
KW - ischemic stroke
KW - Manhattan
KW - cholesterol
KW - 2009
KW - Cerebral Ischemia
KW - Cerebrovascular Accidents
KW - Cholesterol
KW - Lipids
KW - Risk Factors
KW - 2009
U1 - Sponsor: National Institutes of Health, National Institute of Neurological Disorders and Stroke, US. Grant: R37 NS 29993. Recipients: No recipient indicated
U1 - Sponsor: National Institute of Neurological Disorders and Stroke, US. Grant: T32 NS 07153. Recipients: No recipient indicated
DO - 10.1001/archneurol.2009.210
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-22795-015&site=ehost-live&scope=site
UR - mse13@columbia.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-23900-014
AN - 2009-23900-014
AU - Buck, Jeffrey A.
T1 - Recent changes in Medicaid policy and their possible effects on mental health services.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/11//
VL - 60
IS - 11
SP - 1504
EP - 1509
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Buck, Jeffrey A., Center for Mental Health Services, Substance Abuse and Mental Health Services, Administration, 1 Choke Cherry Rd., Room 2-1089, Rockville, MD, US, 20857
N1 - Accession Number: 2009-23900-014. PMID: 19880469 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Buck, Jeffrey A.; Center for Mental Health Services, Substance Abuse and Mental Health Services, Rockville, MD, US. Release Date: 20100705. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Delivery; Medicaid; Mental Health Services; Public Health Services; Health Care Policy. Minor Descriptor: Treatment. Classification: Health & Mental Health Services (3370). Population: Human (10). References Available: Y. Page Count: 6. Issue Publication Date: Nov, 2009.
AB - As Medicaid has emerged as the primary funder of public mental health services, its character has affected the organization and delivery of such services. Recent changes to the program, however, promise to further affect the direction of changes in states' mental health service systems. One group of changes will further limit the flexibility of Medicaid mental health funding, while increasing provider accountability and the authority of state Medicaid agencies. Others will increase incentives for deinstitutionalization and community-based care and promote person-centered treatment principles. These changes will likely affect state mental health systems, mental health providers, and the nature of service delivery. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medicaid policy
KW - mental health services
KW - public mental health services
KW - health care delivery
KW - treatment
KW - 2009
KW - Health Care Delivery
KW - Medicaid
KW - Mental Health Services
KW - Public Health Services
KW - Health Care Policy
KW - Treatment
KW - 2009
DO - 10.1176/appi.ps.60.11.1504
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-23900-014&site=ehost-live&scope=site
UR - jeff.buck@samhsa.hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19220-003
AN - 2009-19220-003
AU - Rashid, Jamila R.
AU - Spengler, Robert F.
AU - Wagner, Robin M.
AU - Melanson, Cindi
AU - Skillen, Elizabeth L.
AU - Mays, Robert A. Jr.
AU - Heurtin-Roberts, Suzanne
AU - Long, Judith A.
T1 - Eliminating health disparities through transdisciplinary research, cross-agency collaboration, and public participation.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/11/01/
VL - 99
IS - 11
SP - 1955
EP - 1961
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Rashid, Jamila R., Office of Minority Health, 1101 Wootton Parkway, Suite 600, Rockville, MD, US, 20852
N1 - Accession Number: 2009-19220-003. PMID: 19762652 Partial author list: First Author & Affiliation: Rashid, Jamila R.; Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20100308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Collaboration; Group Participation; Interdisciplinary Research; Health Disparities. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 7. Issue Publication Date: Nov 1, 2009. Publication History: Accepted Date: Jul 5, 2009.
AB - Despite efforts to the contrary, disparities in health and health care persist in the United States. To solve this problem, federal agencies representing different disciplines and perspectives are collaborating on a variety of transdisciplinary research initiatives. The most recent of these initiatives was launched in 2006 when the Centers for Disease Control and Prevention's Office of Public Health Research and the Department of Health and Human Services’ Office of Minority Health brought together federal partners representing a variety of disciplines to form the Federal Collaboration on Health Disparities Research (FCHDR). FCHDR collaborates with a wide variety of federal and nonfederal partners to support and disseminate research that aims to reduce or eliminate disparities in health and health care. Given the complexity involved in eliminating health disparities, there is a need for more transdisciplinary, collaborative research, and facilitating that research is FCHDR's mission. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - health disparities elimination
KW - transdisciplinary research
KW - cross-agency collaboration
KW - public participation
KW - 2009
KW - Collaboration
KW - Group Participation
KW - Interdisciplinary Research
KW - Health Disparities
KW - 2009
DO - 10.2105/AJPH.2009.167932
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19220-003&site=ehost-live&scope=site
UR - jamila.rashid@hhs.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-19220-004
AN - 2009-19220-004
AU - Safran, Marc A.
AU - Mays, Robert A. Jr.
AU - Huang, Larke Nahme
AU - Mc Cuan, Ron
AU - Pham, Phuong Kim
AU - Fisher, Sylvia Kay
AU - McDuffie, Kathleen Y.
AU - Trachtenberg, Alan
T1 - Mental health disparities.
JF - American Journal of Public Health
JO - American Journal of Public Health
JA - Am J Public Health
Y1 - 2009/11/01/
VL - 99
IS - 11
SP - 1962
EP - 1966
CY - US
PB - American Public Health Assn
SN - 0090-0036
SN - 1541-0048
AD - Safran, Marc A., Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop E-44, Atlanta, GA, US, 30333
N1 - Accession Number: 2009-19220-004. PMID: 19820213 Partial author list: First Author & Affiliation: Safran, Marc A.; Centers for Disease Control and Prevention, Atlanta, GA, US. Release Date: 20100308. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Experimentation; Mental Health; Mental Health Services; Health Disparities. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. References Available: Y. Page Count: 5. Issue Publication Date: Nov 1, 2009. Publication History: Accepted Date: Sep 4, 2009.
AB - Mental health disparities have received increased attention in the literature in recent years. After considering 165 different health disparity conditions, the Federal Collaborative for Health Disparities Research chose mental health disparity as one of four topics warranting its immediate national research attention. In this essay, we describe the challenges and opportunities encountered in developing a research agenda to address mental health disparities in the United States. Varying definitions of mental health disparity, the heterogeneity of populations facing such disparity, and the power, complexity, and intertwined nature of contributing factors are among the many challenges. We convey an evolving interagency approach to mental health disparities research and guidance for further work in the field. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - mental health disparities
KW - research agenda
KW - public health initiatives
KW - 2009
KW - Experimentation
KW - Mental Health
KW - Mental Health Services
KW - Health Disparities
KW - 2009
DO - 10.2105/AJPH.2009.167346
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-19220-004&site=ehost-live&scope=site
UR - MSafran@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105290439
T1 - Shelley Davis: public health advocate at the service of the farmworker.
AU - Baron S
AU - Liebman AK
AU - Ruiz V
AU - Steege AL
Y1 - 2009/11/02/Nov2009 Supplement
N1 - Accession Number: 105290439. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; biography; pictorial. Supplement Title: Nov2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Agriculture
KW - Consumer Advocacy
KW - Occupational Exposure -- Prevention and Control
KW - Public Health
KW - Child
KW - Employment
KW - Environment
KW - Farmworkers
KW - History
KW - Infection Control
KW - Work -- In Infancy and Childhood
KW - Davis S
SP - S505
EP - 7
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S3
CY - Washington, District of Columbia
PB - American Public Health Association
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. sbaron@cdc.gov
U2 - PMID: 19890148.
DO - 10.2105/AJPH.2009.174318
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290439&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290440
T1 - Partnerships for environmental and occupational justice: contributions to research, capacity and public health.
AU - Baron S
AU - Sinclair R
AU - Payne-Sturges D
AU - Phelps J
AU - Zenick H
AU - Collman GW
AU - O'Fallon LR
Y1 - 2009/11/02/Nov2009 Supplement
N1 - Accession Number: 105290440. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Nov2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Cooperative Behavior
KW - Environmental Health
KW - Occupational Health
KW - Public Health
KW - Research
KW - Communities
KW - Human
KW - National Institutes of Health (U.S.)
KW - Organizational Development
KW - Program Evaluation
KW - United States
SP - S517
EP - 25
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S3
CY - Washington, District of Columbia
PB - American Public Health Association
AB - In 1994, the National Institute of Environmental Health Sciences (NIEHS) initiated a program to address communication gaps between community residents, researchers and health care providers in the context of disproportionate environmental exposures. Over 13 years, together with the Environmental Protection Agency and National Institute for Occupational Health and Safety, NIEHS funded 54 environmental justice projects. Here we examine the methods used and outcomes produced based on data gathered from summaries submitted for annual grantees' meetings. Data highlight how projects fulfilled program objectives of improving community awareness and capacity and the positive public health and public policy outcomes achieved. Our findings underscore the importance of community participation in developing effective, culturally sensitive interventions and emphasize the importance of systematic program planning and evaluation.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA. SBaron@cdc.gov
U2 - PMID: 19890151.
DO - 10.2105/AJPH.2009.174557
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290440&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290442
T1 - The role for community-based participatory research in formulating policy initiatives: promoting safety and health for in-home care workers and their consumers.
AU - Gong F
AU - Baron S
AU - Ayala L
AU - Stock L
AU - McDevitt S
AU - Heaney C
Y1 - 2009/11/02/Nov2009 Supplement
N1 - Accession Number: 105290442. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Supplement Title: Nov2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. Grant Information: National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. NLM UID: 1254074.
KW - Health Services Research
KW - Home Health Aides
KW - Occupational Health
KW - Policy Making
KW - Conceptual Framework
KW - Disabled
KW - Focus Groups
KW - Funding Source
KW - Health Policy
KW - Human
KW - Interviews
KW - Quality of Health Care
SP - S531
EP - 8
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S3
CY - Washington, District of Columbia
PB - American Public Health Association
AB - Although community-based participatory research (CBPR) can be effective in influencing policy, the process of formulating policy initiatives through CBPR is understudied. We describe a case study to illustrate how alliances among various community partners could be united to formulate policy directions. In collaboration with partners, the National Institute for Occupational Safety and Health initiated a project aimed at improving health and safety for low-income elderly and disabled persons and their in-home care workers. Community partners and stakeholders participated in focus groups, stakeholder interviews, and meetings; they played multiple roles including identifying organizational policy changes the partners could initiate immediately, as well as broader public policy goals. Results indicated that a strong community partnership, participation, and shared values contributed to successful formulation of policy initiatives.
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
U2 - PMID: 19890153.
DO - 10.2105/AJPH.2008.152405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290442&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105290446
T1 - Alice Hamilton (1869-1970): mother of US occupational medicine.
AU - Baron SL
AU - Brown TM
Y1 - 2009/11/02/Nov2009 Supplement
N1 - Accession Number: 105290446. Language: English. Entry Date: 20100219. Revision Date: 20150711. Publication Type: Journal Article; biography. Supplement Title: Nov2009 Supplement. Journal Subset: Biomedical; Core Nursing; Double Blind Peer Reviewed; Nursing; Peer Reviewed; Public Health; USA. Special Interest: Public Health. NLM UID: 1254074.
KW - Occupational Medicine -- History
KW - History
KW - Leadership
KW - Socioeconomic Factors
KW - Hamilton A
SP - S548
EP - S548
JO - American Journal of Public Health
JF - American Journal of Public Health
JA - AM J PUBLIC HEALTH
VL - 99
IS - S3
CY - Washington, District of Columbia
PB - American Public Health Association
SN - 0090-0036
AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-17, Cincinnati, OH 45226, USA. SBaron@cdc.gov
U2 - PMID: 19890156.
DO - 10.2105/AJPH.2009.177394
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105290446&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kenney, Genevieve M.
AU - Ruhter, Joel
AU - Selden, Thomas M.
T1 - Containing Costs And Improving Care For Children In Medicaid And CHIP.
JO - Health Affairs
JF - Health Affairs
Y1 - 2009/11/02/2009 Web Exclusives from 28-6
VL - 28
M3 - Article
SP - w1025
EP - w1036
SN - 02782715
AB - The current health reform debate is greatly concerned with bending the curve" of cost growth and containing costs, particularly in public programs. Our research demonstrates that spending in Medicaid and the Children's Health Insurance Program (CHIP) is highly concentrated, particularly among children with chronic health problems. Ten percent of enrollees (two-thirds of whom have a chronic condition) account for 72 percent of the spending; 30 percent of enrolled children receive little or no care. These results highlight the importance of cost containment strategies that reduce avoidable hospitalizations among children with chronic problems and policies that increase preventive care, particularly among African American children. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Affairs is the property of Project HOPE/HEALTH AFFAIRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MEDICAL social work
KW - MEDICAL care costs
KW - RESEARCH
KW - HEALTH care reform
KW - CHILD health insurance
KW - MEDICAID -- Economic aspects
KW - MEDICAL care cost control
KW - CHRONIC diseases in children
KW - POLITICAL debates & debating
KW - AFRICAN American children
KW - MEDICAL care
KW - MEDICAID
KW - STATISTICS
KW - CHILD health services
KW - CHILDREN -- Hospital care
KW - COST control
KW - NEEDS assessment (Medical care)
KW - MEDICAL care use
KW - PREVENTIVE health services
KW - QUALITY assurance
KW - RESEARCH -- Finance
KW - HEALTH services administration
KW - DESCRIPTIVE statistics
KW - ECONOMIC aspects
KW - UNITED States
N1 - Accession Number: 50220113; Kenney, Genevieve M. 1; Email Address: jkenney@urban.org Ruhter, Joel 2 Selden, Thomas M. 3; Affiliation: 1: Urban Institute, Washington, D.C. 2: University of Michigan, Ann Arbor 3: Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and quality, Rockville, Maryland; Source Info: 2009 Web Exclusives from 28-6, Vol. 28, pw1025; Subject Term: MEDICAL social work; Subject Term: MEDICAL care costs; Subject Term: RESEARCH; Subject Term: HEALTH care reform; Subject Term: CHILD health insurance; Subject Term: MEDICAID -- Economic aspects; Subject Term: MEDICAL care cost control; Subject Term: CHRONIC diseases in children; Subject Term: POLITICAL debates & debating; Subject Term: AFRICAN American children; Subject Term: MEDICAL care; Subject Term: MEDICAID; Subject Term: STATISTICS; Subject Term: CHILD health services; Subject Term: CHILDREN -- Hospital care; Subject Term: COST control; Subject Term: NEEDS assessment (Medical care); Subject Term: MEDICAL care use; Subject Term: PREVENTIVE health services; Subject Term: QUALITY assurance; Subject Term: RESEARCH -- Finance; Subject Term: HEALTH services administration; Subject Term: DESCRIPTIVE statistics; Subject Term: ECONOMIC aspects; Subject Term: UNITED States; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 12p; Document Type: Article
L3 - 10.1377/hlthaff.28.6.w1025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=50220113&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 107882799
T1 - Containing Costs And Improving Care For Children In Medicaid And CHIP.
AU - Kenney, Genevieve M.
AU - Ruhter, Joel
AU - Selden, Thomas M.
Y1 - 2009/11/02/2009 Web Exclusives from 28-6
N1 - Accession Number: 107882799. Language: English. Entry Date: 20140131. Revision Date: 20150712. Publication Type: Journal Article; research; tables/charts. Supplement Title: 2009 Web Exclusives from 28-6. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Pediatric Care. Grant Information: David and Lucile Packard Foundation; Agency for Healthcare Research and Quality.. NLM UID: 8303128.
KW - Cost Control
KW - Quality Improvement
KW - Child Health Services
KW - Medicaid -- Statistics and Numerical Data -- United States
KW - Health Resource Utilization
KW - Human
KW - Health Care Reform
KW - Child, Medically Fragile
KW - Child, Hospitalized
KW - Preventive Health Care
KW - Administrative Research -- United States
KW - United States
KW - Descriptive Statistics
KW - Health Services Needs and Demand
KW - Funding Source
SP - w1025
EP - 36
JO - Health Affairs
JF - Health Affairs
JA - HEALTH AFF
VL - 28
CY - Bethesda, Maryland
PB - Project HOPE/HEALTH AFFAIRS
AB - The current health reform debate is greatly concerned with bending the curve' of cost growth and containing costs, particularly in public programs. Our research demonstrates that spending in Medicaid and the Children's Health Insurance Program (CHIP) is highly concentrated, particularly among children with chronic health problems. Ten percent of enrollees (two-thirds of whom have a chronic condition) account for 72 percent of the spending; 30 percent of enrolled children receive little or no care. These results highlight the importance of cost containment strategies that reduce avoidable hospitalizations among children with chronic problems and policies that increase preventive care, particularly among African American children.
SN - 0278-2715
AD - Urban Institute, Washington, D.C.
AD - University of Michigan, Ann Arbor
AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and quality, Rockville, Maryland
U2 - PMID: 19762355.
DO - 10.1377/hlthaff.28.6.w1025
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=107882799&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bányai, Krisztián
AU - Gentsch, Jon R.
AU - Martella, Vito
AU - Bogdán, Ágnes
AU - Havasi, Viktória
AU - Kisfali, Pé ter
AU - Szabó,, Alíz
AU - Mihá ly, Ilona
AU - Molná r, Pé ter
AU - Melegh, Bé la
AU - Szücs, György
T1 - Trends in the Epidemiology of Human G1P[8] Rotaviruses: A Hungarian Study.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/11/02/
VL - 200
IS - S1
M3 - Article
SP - S222
EP - S227
SN - 00221899
AB - Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EPIDEMIOLOGY
KW - ROTAVIRUSES
KW - ANTIGENS
KW - GENES
KW - STRAIN (Physiology)
KW - RNA
KW - PEPTIDES
KW - AMINO acids
KW - HUNGARY
N1 - Accession Number: 45082394; Bányai, Krisztián 1,2,3 Gentsch, Jon R. 4 Martella, Vito 5 Bogdán, Ágnes 2 Havasi, Viktória 6 Kisfali, Pé ter 6 Szabó,, Alíz 1 Mihá ly, Ilona 7 Molná r, Pé ter 7 Melegh, Bé la 6 Szücs, György 1,2; Affiliation: 1: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Budapest, Hungary 2: Departments of Medical Microbiology and Immunology, Budapest, Hungary 3: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary 4: Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 5: Department of Animal Health and Well-Being, University of Bari, Bari, Italy 6: Medical Genetics and Child Development, Faculty of Medicine, University of Pécs, Pécs, Budapest, Hungary 7: Laboratory for Diagnostic Virology, St. Laszlo Central Hospital for Infectious Diseases, Budapest, Hungary; Source Info: 11/2/2009, Vol. 200 Issue S1, pS222; Subject Term: EPIDEMIOLOGY; Subject Term: ROTAVIRUSES; Subject Term: ANTIGENS; Subject Term: GENES; Subject Term: STRAIN (Physiology); Subject Term: RNA; Subject Term: PEPTIDES; Subject Term: AMINO acids; Subject Term: HUNGARY; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1086/605052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45082394&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105332760
T1 - Trends in the epidemiology of human G1P[8] rotaviruses: a Hungarian study.
AU - Bányai K
AU - Gentsch JR
AU - Martella V
AU - Bogdán A
AU - Havasi V
AU - Kisfali P
AU - Szabó A
AU - Mihály I
AU - Molnár P
AU - Melegh B
AU - Szücs G
Y1 - 2009/11/02/
N1 - Accession Number: 105332760. Language: English. Entry Date: 20091113. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Rotavirus Infections -- Epidemiology
KW - Rotaviruses
KW - Amino Acids
KW - Antigens, Viral
KW - Hungary
KW - Proteins
KW - Rotavirus Infections
KW - Rotaviruses -- Classification
KW - Time Factors
SP - S222
EP - 7
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 200
IS - S1
PB - Oxford University Press / USA
AB - Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents.
SN - 0022-1899
AD - Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Hungarian Academy of Sciences, Budapest, Hungary. bkrota@hotmail.com
U2 - PMID: 19821713.
DO - 10.1086/605052
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105332760&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Tsertsvadze, Alexander
AU - Fink, Howard A.
AU - Yazdi, Fatemeh
AU - MacDonald, Roderick
AU - Bella, Anthony J.
AU - Ansari, Mohammed T.
AU - Garritty, Chantelle
AU - Soares-Weiser, Karla
AU - Daniel, Raymond
AU - Sampson, Margaret
AU - Fox, Steven
AU - Moher, David
AU - Wilt, Timothy J.
T1 - Oral Phosphodiesterase-5 Inhibitors and Hormonal Treatments for Erectile Dysfunction: A Systematic Review and Meta-analysis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/11/03/
VL - 151
IS - 9
M3 - Article
SP - 650
EP - W218
SN - 00034819
AB - Background: Erectile dysfunction (ED) is a common male sexual disorder. The relative benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal testing in men with ED, are uncertain. Purpose: To evaluate the efficacy and harms of oral phosphodiesterase- 5 (PDE-5) inhibitors and hormonal treatments for ED and assess the effect of measuring serum hormone levels on treatment outcomes for ED. Data Sources: English-language studies from MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, and SCOPUS through April 2009. Trial reference lists also were scanned. Study Selection: Randomized, controlled trials (RCTs) of oral PDE-5 inhibitors and hormonal treatment for ED, and observational studies reporting measurement of serum hormone levels, prevalence of hormonal abnormalities, or both in men with ED. Data Extraction: Two independent reviewers abstracted data on study, participant, and treatment characteristics; efficacy and harms outcomes; and prevalence of hormonal abnormalities. Data Synthesis: Data, primarily from short-term trials (⩽12 weeks), indicate that PDE-5 inhibitors were more effective than placebo in improving sexual intercourse success (69.0% vs. 35.0%). The proportion of men with improved erections was significantly greater among those treated with PDE-5 inhibitors (range, 67.0% to 89.0%) than with placebo (range, 27.0% to 35.0%). The PDE-5 inhibitors were associated with increased risk for any adverse events compared with placebo (for example, relative risk with sildenafil, 1.72 [95% CI, 1.53 to 1.93]). In 4 head-to-head RCTs comparing sildenafil, vardenafil, and tadalafil, improvement of ED and adverse events did not differ among treatments. Results from 15 RCTs evaluating hormonal treatment of ED were inconsistent on whether treatment improved outcomes. Evidence was insufficient regarding whether men with ED had a higher prevalence of hypogonadism than men without ED. Limitations: Many RCTs were of low methodological and reporting quality, particularly those involving hormonal treatments or directly comparing different PDE-5 inhibitors. Most RCTs provided only short-term efficacy and harms data. Conclusion: Oral PDE-5 inhibitors improved erectile functioning and had similar efficacy and safety profiles. Results on the efficacy of hormonal treatments and the value of hormone testing in men with ED were inconclusive. Primary Funding Source: Agency for Healthcare Research and Quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMPOTENCE
KW - PHOSPHODIESTERASES
KW - META-analysis
KW - PHARMACOLOGY
N1 - Accession Number: 45590291; Tsertsvadze, Alexander 1 Fink, Howard A. 2; Email Address: howard.fink@va.gov Yazdi, Fatemeh 1 MacDonald, Roderick 3 Bella, Anthony J. 4 Ansari, Mohammed T. 5 Garritty, Chantelle 6 Soares-Weiser, Karla 7 Daniel, Raymond 1 Sampson, Margaret 8 Fox, Steven 9 Moher, David 10 Wilt, Timothy J. 3; Affiliation: 1: Ottawa Hospital Research Institute, 501 Smyth Road, Room W0575, Box 208, Ottawa, Ontario K1H 8L6, Canada. 2: Veterans Affairs Medical Center (11-G), One Veterans Drive, Minneapolis, MN 55417. 3: Veterans Affairs Medical Center (111-0), One Veterans Drive, Minneapolis, MN 55417. 4: University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada. 5: Ottawa Hospital Research Institute, 501 Smyth Road, Room W0589, Box 208, Ottawa, Ontario K1H 8L6, Canada. 6: Ottawa Hospital Research Institute, 501 Smyth Road, Room W0585, Box 208, Ottawa, Ontario K1H 8L6, Canada. 7: PO Box 137, Enhance Reviews, Kfar-Saba 44101, Israel. 8: Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. 9: Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850. 10: Ottawa Hospital Research Institute, 501 Smyth Road, Room W6112, Box 208, Ottawa, Ontario K1H 8L6, Canada.; Source Info: 11/3/2009, Vol. 151 Issue 9, p650; Subject Term: IMPOTENCE; Subject Term: PHOSPHODIESTERASES; Subject Term: META-analysis; Subject Term: PHARMACOLOGY; Number of Pages: 22p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45590291&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Tsertsvadze, Alexander
AU - Fink, Howard A.
AU - Yazdi, Fatemeh
AU - MacDonald, Roderick
AU - Bella, Anthony J.
AU - Ansari, Mohammed T.
AU - Garritty, Chantelle
AU - Soares-Weiser, Karla
AU - Daniel, Raymond
AU - Sampson, Margaret
AU - Fox, Steven
AU - Moher, David
AU - Wilt, Timothy J.
T1 - Oral Phosphodiesterase-5 Inhibitors and Hormonal Treatments for Erectile Dysfunction: A Systematic Review and Meta-analysis.
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
Y1 - 2009/11/03/
VL - 151
IS - 9
M3 - Article
SP - 650
EP - W218
SN - 00034819
AB - Background: Erectile dysfunction (ED) is a common male sexual disorder. The relative benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal testing in men with ED, are uncertain. Purpose: To evaluate the efficacy and harms of oral phosphodiesterase- 5 (PDE-5) inhibitors and hormonal treatments for ED and assess the effect of measuring serum hormone levels on treatment outcomes for ED. Data Sources: English-language studies from MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, AMED, and SCOPUS through April 2009. Trial reference lists also were scanned. Study Selection: Randomized, controlled trials (RCTs) of oral PDE-5 inhibitors and hormonal treatment for ED, and observational studies reporting measurement of serum hormone levels, prevalence of hormonal abnormalities, or both in men with ED. Data Extraction: Two independent reviewers abstracted data on study, participant, and treatment characteristics; efficacy and harms outcomes; and prevalence of hormonal abnormalities. Data Synthesis: Data, primarily from short-term trials (⩽12 weeks), indicate that PDE-5 inhibitors were more effective than placebo in improving sexual intercourse success (69.0% vs. 35.0%). The proportion of men with improved erections was significantly greater among those treated with PDE-5 inhibitors (range, 67.0% to 89.0%) than with placebo (range, 27.0% to 35.0%). The PDE-5 inhibitors were associated with increased risk for any adverse events compared with placebo (for example, relative risk with sildenafil, 1.72 [95% CI, 1.53 to 1.93]). In 4 head-to-head RCTs comparing sildenafil, vardenafil, and tadalafil, improvement of ED and adverse events did not differ among treatments. Results from 15 RCTs evaluating hormonal treatment of ED were inconsistent on whether treatment improved outcomes. Evidence was insufficient regarding whether men with ED had a higher prevalence of hypogonadism than men without ED. Limitations: Many RCTs were of low methodological and reporting quality, particularly those involving hormonal treatments or directly comparing different PDE-5 inhibitors. Most RCTs provided only short-term efficacy and harms data. Conclusion: Oral PDE-5 inhibitors improved erectile functioning and had similar efficacy and safety profiles. Results on the efficacy of hormonal treatments and the value of hormone testing in men with ED were inconclusive. Primary Funding Source: Agency for Healthcare Research and Quality. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - IMPOTENCE
KW - PHOSPHODIESTERASES
KW - META-analysis
KW - PHARMACOLOGY
N1 - Accession Number: 45590291; Tsertsvadze, Alexander 1; Fink, Howard A. 2; Email Address: howard.fink@va.gov; Yazdi, Fatemeh 1; MacDonald, Roderick 3; Bella, Anthony J. 4; Ansari, Mohammed T. 5; Garritty, Chantelle 6; Soares-Weiser, Karla 7; Daniel, Raymond 1; Sampson, Margaret 8; Fox, Steven 9; Moher, David 10; Wilt, Timothy J. 3; Source Information: 11/3/2009, Vol. 151 Issue 9, p650; Subject: IMPOTENCE; Subject: PHOSPHODIESTERASES; Subject: META-analysis; Subject: PHARMACOLOGY; Number of Pages: 22p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=hch&AN=45590291&site=ehost-live&scope=site
DP - EBSCOhost
DB - hch
ER -
TY - JOUR
ID - 105339749
T1 - CDC and FDA Response to Risk of Confusion in Dosing Tamiflu Oral Suspension...N Engl J Med. 2009 Nov 5;361(19):1912-3
AU - Budnitz DS
AU - Lewis LL
AU - Shehab N
AU - Birnkrant D
Y1 - 2009/11/05/
N1 - Accession Number: 105339749. Language: English. Entry Date: 20091127. Revision Date: 20150711. Publication Type: Journal Article; commentary; letter. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Antiviral Agents -- Administration and Dosage
KW - Dosage Forms
KW - Drug Labeling -- Standards
KW - Enzyme Inhibitors -- Administration and Dosage
KW - Medication Errors -- Prevention and Control
KW - Administration, Oral
KW - Centers for Disease Control and Prevention (U.S.)
KW - United States Food and Drug Administration
KW - United States
SP - 1913
EP - 1914
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 361
IS - 19
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Centers for Disease Control and Prevention, Atlanta, GA, dbudnitz@cdc.gov, Food and Drug Administration, Rockville, MD, Centers for Disease Control and Prevention, Atlanta, GA, Food and Drug Administration, Rockville, MD.
U2 - PMID: 19797275.
DO - 10.1056/NEJMc0909190
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105339749&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Shaikh, Badar
AU - Rummel, Nathan
AU - Gieseker, Charles
AU - Cheely, Christie-Sue
AU - Reimschuessel, Renate
T1 - Residue depletion of albendazole and its metabolites in the muscle tissue of large mouth and hybrid striped bass after oral administration
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2009/11/13/
VL - 1216
IS - 46
M3 - Article
SP - 8173
EP - 8176
SN - 00219673
AB - Abstract: The residue depletion profiles of albendazole (ABZ) and its major metabolites: albendazole sulfoxide (ABZ-SO), albendazole sulfone (ABZ-SO2) and albendazole aminosulfone (ABZ-2-NH2SO2) were studied in the muscle tissues of large mouth (LMB) and hybrid striped bass (HSB). A single oral dose of 10mg/kg albendazole was given to the two fish species via intra-gastric tube. The muscle tissues with adhering skin were collected at 8, 16, 24, 48, 72, 96 and 120h post dose from both species. The samples were homogenized in dry ice and subjected to extraction and cleanup procedures. The final sample extracts were analyzed by high performance liquid chromatography. The results indicate that both ABZ and its pharmacologically active metabolite ABZ-SO were retained longer in LMB than in HSB after oral treatment. Albendazole was detectable until 8h or 6.7 degree days (°D) and 48h (40°D) in HSB and LMB, respectively. However, ABZ-SO was detectable up to 48h (40°D) and 96h (80°D) in HSB and LMB, respectively. Among the inactive metabolites, ABZ-SO2 was present in both fish species; however, ABZ-2-NH2SO2 was detected only in LMB. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ALBENDAZOLE
KW - METABOLITES
KW - STRIPED bass
KW - SULFOXIDES
KW - DOSAGE of drugs
KW - ORAL medication
KW - ADMINISTRATION of drugs
KW - EXTRACTION (Chemistry)
KW - HIGH performance liquid chromatography
KW - Aquaculture
KW - HPLC
KW - Hybrid striped bass
KW - Large mouth bass
KW - Metabolism
KW - Residue depletion
N1 - Accession Number: 44829252; Shaikh, Badar; Email Address: Badaruddin.Shaikh@fda.hhs.gov Rummel, Nathan 1 Gieseker, Charles 1 Cheely, Christie-Sue 1 Reimschuessel, Renate 1; Affiliation: 1: Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Nov2009, Vol. 1216 Issue 46, p8173; Subject Term: ALBENDAZOLE; Subject Term: METABOLITES; Subject Term: STRIPED bass; Subject Term: SULFOXIDES; Subject Term: DOSAGE of drugs; Subject Term: ORAL medication; Subject Term: ADMINISTRATION of drugs; Subject Term: EXTRACTION (Chemistry); Subject Term: HIGH performance liquid chromatography; Author-Supplied Keyword: Aquaculture; Author-Supplied Keyword: HPLC; Author-Supplied Keyword: Hybrid striped bass; Author-Supplied Keyword: Large mouth bass; Author-Supplied Keyword: Metabolism; Author-Supplied Keyword: Residue depletion; NAICS/Industry Codes: 114111 Finfish Fishing; NAICS/Industry Codes: 112511 Finfish Farming and Fish Hatcheries; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.chroma.2009.04.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44829252&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Smith, Shani
AU - Gieseker, Charles
AU - Reimschuessel, Renate
AU - Decker, Christie-Sue
AU - Carson, Mary C.
T1 - Simultaneous screening and confirmation of multiple classes of drug residues in fish by liquid chromatography-ion trap mass spectrometry
JO - Journal of Chromatography A
JF - Journal of Chromatography A
Y1 - 2009/11/13/
VL - 1216
IS - 46
M3 - Article
SP - 8224
EP - 8232
SN - 00219673
AB - Abstract: LC-ion trap mass spectrometry was used to screen and confirm 38 compounds from a variety of drug classes in four species of fish: trout, salmon, catfish, and tilapia. Samples were extracted with acetonitrile and hexane. The acetonitrile phase was evaporated, redissolved in water and acetonitrile, and analyzed by gradient chromatography on a phenyl column. MS2 or MS3 spectra were monitored for each compound. Qualitative method performance was evaluated by the analysis over several days of replicate samples of control fish, fish fortified with a drug mixture at 1ppm, 0.1ppm and 0.01ppm, and fish dosed with a representative from each drug class. Half of the 38 drugs were confirmed at 0.01ppm, the lowest fortification level. This included all of the quinolones and fluoroquinolones, the macrolides, malachite green, and most of the imidazoles. Florfenicol amine, metronidazole, sulfonamides, tetracyclines, and most of the betalactams were confirmed at 0.1ppm. Ivermectin and penicillin G were only detectable in the 1ppm fortified samples. With the exception of amoxicillin, emamectin, metronidazole, and tylosin, residue presence was confirmed in all the dosed fish. [Copyright &y& Elsevier]
AB - Copyright of Journal of Chromatography A is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DRUGS -- Analysis
KW - LIQUID chromatography
KW - PENNING trap mass spectrometry
KW - ACETONITRILE
KW - EXTRACTION (Chemistry)
KW - HEXANE
KW - EVAPORATION (Chemistry)
KW - SALMON
KW - IMIDAZOLES
KW - Catfish
KW - Confirmation
KW - Drug residues
KW - Ion trap mass spectrometry
KW - Salmon
KW - Tilapia
KW - Trout
N1 - Accession Number: 44829259; Smith, Shani 1 Gieseker, Charles 1 Reimschuessel, Renate 1 Decker, Christie-Sue 1 Carson, Mary C.; Email Address: mary.carson@fda.hhs.gov; Affiliation: 1: Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708, USA; Source Info: Nov2009, Vol. 1216 Issue 46, p8224; Subject Term: DRUGS -- Analysis; Subject Term: LIQUID chromatography; Subject Term: PENNING trap mass spectrometry; Subject Term: ACETONITRILE; Subject Term: EXTRACTION (Chemistry); Subject Term: HEXANE; Subject Term: EVAPORATION (Chemistry); Subject Term: SALMON; Subject Term: IMIDAZOLES; Author-Supplied Keyword: Catfish; Author-Supplied Keyword: Confirmation; Author-Supplied Keyword: Drug residues; Author-Supplied Keyword: Ion trap mass spectrometry; Author-Supplied Keyword: Salmon; Author-Supplied Keyword: Tilapia; Author-Supplied Keyword: Trout; NAICS/Industry Codes: 114114 Freshwater fishing; NAICS/Industry Codes: 114111 Finfish Fishing; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.chroma.2009.06.077
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44829259&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105242669
T1 - Screening for type 2 diabetes mellitus in adults.
AU - Lin KW
AU - Chang C
Y1 - 2009/11/15/
N1 - Accession Number: 105242669. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Diabetes Mellitus, Type 2 -- Diagnosis
KW - Diabetes Mellitus, Type 2 -- Prevention and Control
KW - Diabetes Mellitus, Type 2 -- Therapy
KW - Early Diagnosis
KW - Female
KW - Health Screening
KW - Middle Age
SP - 1141
EP - 1141
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 80
IS - 10
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Preventive Services Task Force Program, Agency for Healthcare Research and Quality, Bethesda, MA, USA.
U2 - PMID: 19904899.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105242669&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - GEN
AU - Lei Nie
T1 - Re: “Methods of Covariate Selection: Directed Acyclic Graphs and the Change-in-Estimate Procedure”.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/11/15/
VL - 170
IS - 10
M3 - Letter
SP - 1320
EP - 1320
SN - 00029262
AB - A letter to the editor is presented in response to the article "Methods of Covariate Selection: Directed Acyclic Graphs and the Change-in-Estimate Procedure," by H. Y. Weng et al. in a 2009 issue.
KW - LETTERS to the editor
KW - ANALYSIS of covariance
N1 - Accession Number: 45304937; Lei Nie 1; Email Address: lei.nie@fda.hhs.gov; Affiliation: 1: Division of Biometrics IV, Office of Biometrics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002; Source Info: Nov2009, Vol. 170 Issue 10, p1320; Subject Term: LETTERS to the editor; Subject Term: ANALYSIS of covariance; Number of Pages: 1p; Document Type: Letter
L3 - 10.1093/aje/kwp267
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Donnelly, Raymond P.
AU - Young, Howard A.
AU - Rosenberg, Amy S.
T1 - An Overview of Cytokines and Cytokine Antagonists as Therapeutic Agents.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2009/11/15/
VL - 1182
IS - 1
M3 - Article
SP - 1
EP - 13
SN - 00778923
AB - Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the FDA partnered with the New York Academy of Sciences in March 2009 to host a two-day forum to discuss more effective ways to harness the clinical potential of cytokines and cytokine antagonists as therapeutic agents. The first day was focused primarily on the use of recombinant cytokines as therapeutic agents for treatment of human diseases. The second day focused largely on the use of cytokine antagonists as therapeutic agents for treatment of human diseases. This issue of the Annals includes more than a dozen papers that summarize much of the information that was presented during this very informative two-day conference. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CYTOKINES
KW - AUTOIMMUNE diseases
KW - CHEMICAL inhibitors
KW - COMMUNICABLE diseases
KW - DRUGS
KW - cytokines
KW - inflammation
KW - interferons
KW - interleukins
KW - receptors
N1 - Accession Number: 45717628; Donnelly, Raymond P. 1; Email Address: Raymond.Donnelly@fda.hhs.gov Young, Howard A. 2 Rosenberg, Amy S. 1; Affiliation: 1: Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. 2: Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.; Source Info: Nov2009, Vol. 1182 Issue 1, p1; Subject Term: CYTOKINES; Subject Term: AUTOIMMUNE diseases; Subject Term: CHEMICAL inhibitors; Subject Term: COMMUNICABLE diseases; Subject Term: DRUGS; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: interferons; Author-Supplied Keyword: interleukins; Author-Supplied Keyword: receptors; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 13p; Illustrations: 1 Diagram; Document Type: Article
L3 - 10.1111/j.1749-6632.2009.05382.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kozlowski, Steven
AU - Cherney, Barry
AU - Donnelly, Raymond P.
T1 - Hurdles and Leaps for Protein Therapeutics.
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
Y1 - 2009/11/15/
VL - 1182
IS - 1
M3 - Article
SP - 146
EP - 160
SN - 00778923
AB - Cytokines encompass a wide variety of proteins that can trigger many cellular activities. An important set of cytokines modulate inflammatory responses (inflammatory cytokines). These molecules have potent biological activities and have been a major focus for protein drug development. There have been both successes and failures in this area. Initial hurdles, such as limited manufacturing capacity, have now been largely overcome. However clinical development remains a challenge. On the basis of the history of cytokine therapeutics, a number of strategies for future drug development are considered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PROTEIN drugs
KW - DRUG development
KW - CYTOKINES
KW - CHEMOKINES
KW - PHARMACOLOGY
KW - biotechnology
KW - cytokines
KW - inflammation
KW - manufacturing
KW - pharmaceutical development
N1 - Accession Number: 45717632; Kozlowski, Steven 1; Email Address: steven.kozlowski@fda.hhs.gov Cherney, Barry 2 Donnelly, Raymond P. 2; Affiliation: 1: Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, Maryland, USA. 2: Division of Therapeutic Proteins, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. FDA, Bethesda, Maryland, USA.; Source Info: Nov2009, Vol. 1182 Issue 1, p146; Subject Term: PROTEIN drugs; Subject Term: DRUG development; Subject Term: CYTOKINES; Subject Term: CHEMOKINES; Subject Term: PHARMACOLOGY; Author-Supplied Keyword: biotechnology; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: inflammation; Author-Supplied Keyword: manufacturing; Author-Supplied Keyword: pharmaceutical development; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 15p; Illustrations: 2 Diagrams, 1 Chart, 1 Graph; Document Type: Article
L3 - 10.1111/j.1749-6632.2009.05158.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lambourne, Jonathan
AU - Agranoff, Dan
AU - Herbrecht, Raoul
AU - Troke, Peter F.
AU - Buchbinder, Aby
AU - Willis, Fenella
AU - Letscher-Bru, Valérie
AU - Agrawal, Samir
AU - Doffman, Sarah
AU - Johnson, Elizabeth
AU - White, P. Lewis
AU - Barnes, Rosemary A.
AU - Griffin, George
AU - Lindsay, Jodi A.
AU - Harrison, Thomas S.
T1 - Association of Mannose-Binding Lectin Deficiency with Acute Invasive Aspergillosis in Immunocompromised Patients.
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
Y1 - 2009/11/15/
VL - 49
IS - 10
M3 - Article
SP - 1486
EP - 1491
SN - 10584838
AB - Background. Invasive aspergillosis is a devastating infection with attributable mortality of 40% despite antifungal therapy. In animal models of aspergillosis, deficiency of mannose-binding lectin (MBL), a pattern recognition receptor that activates complement, is a susceptibility factor. MBL deficiency occurs in 20%-30% of the population. We hypothesized that MBL deficiency may be a susceptibility factor for invasive aspergillosis in humans. Methods. Serum MBL concentrations were measured by enzyme-linked immunosorbent assay in 65 patients with proven or probable acute invasive aspergillosis and 78 febrile immunocompromised control subjects. MBL concentrations and the frequency of MBL deficiency were compared. Results. The median serum MBL level was significantly lower in patients with aspergillosis than in control subjects (281 ng/mL vs 835 ng/mL; P<.007). MBL deficiency (MBL concentration, <500 ng/mL) was significantly more common in patients with aspergillosis than control subjects (62% vs 32%; P = .001). Frequency of MBL deficiency was similar among patients with aspergillosis irrespective of response to antifungal therapy (P=.10). Conclusions. This study is the first, to our knowledge, to show an association between MBL deficiency and acute invasive aspergillosis in humans. Further study is required to investigate the causal nature of this association and to define whether diagnosis of MBL deficiency may identify immunocompromised patients at increased risk of invasive aspergillosis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Lectins
KW - Antifungal agents
KW - Diseases -- Causes & theories of causation
KW - Aspergillosis
KW - Respiratory diseases
KW - Immunoglobulins
KW - Disease susceptibility
KW - Enzyme-linked immunosorbent assay
KW - Immunoenzyme technique
N1 - Accession Number: 45139513; Lambourne, Jonathan 1; Email Address: jlambourne@sgul.ac.uk; Agranoff, Dan 2; Herbrecht, Raoul 3; Troke, Peter F. 4; Buchbinder, Aby 5; Willis, Fenella 1; Letscher-Bru, Valérie 6; Agrawal, Samir 7,8; Doffman, Sarah 7,8; Johnson, Elizabeth 9; White, P. Lewis 10; Barnes, Rosemary A. 11; Griffin, George 1; Lindsay, Jodi A. 1; Harrison, Thomas S. 1; Affiliations: 1: Division of Cellular and Molecular Medicine, St George's University; 2: Department of Infectious Diseases and Immunity, Imperial College London; 3: Oncology and Haematology, Hôpital de Hautepierre; 4: Global Research and Development, Pfizer, Sandwich; 5: nzon Pharmaceuticals, Bridgewater, New Jersey; 6: Institut de Parasitologie et de Pathologie Tropicale, Strasbourg, France; 7: Centre for Haematology, Institute of Cell and Molecular Science, Queen Mary University of London, St Bartholomew's Hospital; 8: The London School of Medicine and Dentistry, London; 9: Health Protection Agency Mycology Reference Laboratory, Bristol, England; 10: National Public Health Service, University Hospital of Wales; 11: Department of Medical Microbiology, Cardiff University, Cardiff, Wales; Issue Info: 11/15/2009, Vol. 49 Issue 10, p1486; Thesaurus Term: Lectins; Thesaurus Term: Antifungal agents; Thesaurus Term: Diseases -- Causes & theories of causation; Subject Term: Aspergillosis; Subject Term: Respiratory diseases; Subject Term: Immunoglobulins; Subject Term: Disease susceptibility; Subject Term: Enzyme-linked immunosorbent assay; Subject Term: Immunoenzyme technique; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 6p; Illustrations: 2 Graphs; Document Type: Article
L3 - 10.1086/644619
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Gwinn, Maureen R.
AU - Leonard, Stephen S.
AU - Sargent, Linda M.
AU - Lowry, David T.
AU - McKinstry, Kimberly
AU - Meighan, Terry
AU - Reynolds, Steve H.
AU - Kashon, Michael
AU - Castranova, Vince
AU - Vallyathan, Val
T1 - The Role of p53 in Silica-Induced Cellular and Molecular Responses Associated with Carcinogenesis.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2009/11/15/
VL - 72
IS - 23
M3 - Article
SP - 1509
EP - 1519
SN - 15287394
AB - Crystalline silica (silica), a suspected human carcinogen, produces an increase in reactive oxygen species (ROS) when fractured using mechanical tools used in several occupations. Although ROS has been linked to apoptosis, DNA damage, and carcinogenesis, the role of enhanced ROS production by silica in silica-induced carcinogenesis is not completely understood. The goal of this study was to compare freshly fractured and aged silica-induced molecular alterations in human immortalized/transformed bronchial epithelial cells (BEAS-IIB) and lung cancer cells with altered (H460) or deficient (H1299) p53 expression. Exposure to freshly fractured or aged silica produced divergent cellular responses in certain downstream cellular events, including ROS production, apoptosis, cell cycle and chromosomal changes, and gene expression. ROS production increased significantly following exposure to freshly fractured silica compared to aged silica in BEAS-IIB and H460 cells. Apoptosis showed a comparable enhanced level of induction with freshly fractured or aged silica in both cancer lines with p53 functional changes. p53 protein was present in the BEAS-IIB and was absent in cancer cell lines after silica exposure. Exposure to freshly fractured silica also resulted in a rise in aneuploidy in cancer cells with a significantly greater increase in p53-deficient cells. Cytogenetic analysis demonstrated increased metaphase spreads, chromosome breakage, rearrangements, and endoreduplication in both cancer cells. These results suggest that altered and deficient p53 affects the cellular response to freshly fractured silica exposure, and thereby enhances susceptibility and augments cell proliferation and lung cancer development. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SILICA
KW - CARCINOGENS
KW - ACTIVE oxygen
KW - DNA damage
KW - APOPTOSIS
KW - CYTOGENETICS
KW - LUNGS -- Cancer
KW - CARCINOGENESIS
KW - ANEUPLOIDY
N1 - Accession Number: 49234437; Gwinn, Maureen R. 1 Leonard, Stephen S. 1 Sargent, Linda M. 1 Lowry, David T. 1 McKinstry, Kimberly 1 Meighan, Terry 1 Reynolds, Steve H. 1 Kashon, Michael 1 Castranova, Vince 1 Vallyathan, Val 1; Email Address: vav1@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA.; Source Info: Nov2009, Vol. 72 Issue 23, p1509; Subject Term: SILICA; Subject Term: CARCINOGENS; Subject Term: ACTIVE oxygen; Subject Term: DNA damage; Subject Term: APOPTOSIS; Subject Term: CYTOGENETICS; Subject Term: LUNGS -- Cancer; Subject Term: CARCINOGENESIS; Subject Term: ANEUPLOIDY; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 11p; Illustrations: 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 2 Charts, 3 Graphs; Document Type: Article
L3 - 10.1080/15287390903129291
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=49234437&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shenyang Li
AU - Nagothu, Kiran K.
AU - Desai, Varsha
AU - Taewon Lee
AU - Branham, William
AU - Moland, Carrie
AU - Megyesi, Judit K.
AU - Crew, Mark D.
AU - Portilla, Didier
T1 - Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury.
JO - Kidney International
JF - Kidney International
Y1 - 2009/11/15/
VL - 76
IS - 10
M3 - Article
SP - 1049
EP - 1062
SN - 00852538
AB - Our previous studies suggest that peroxisome proliferator–activated receptor-α (PPARα) plays a critical role in regulating fatty acid β-oxidation in kidney tissue and this directly correlated with preservation of kidney morphology and function during acute kidney injury. To further study this, we generated transgenic mice expressing PPARα in the proximal tubule under the control of the promoter of KAP2 (kidney androgen-regulated protein 2). Segment-specific upregulation of PPARα expression by testosterone treatment of female transgenic mice improved kidney function during cisplatin or ischemia–reperfusion-induced acute kidney injury. Ischemia–reperfusion injury or treatment with cisplatin in wild-type mice caused inhibition of fatty-acid oxidation, reduction of mitochondrial genes of oxidative phosphorylation, mitochondrial DNA, fatty-acid metabolism, and the tricarboxylic acid cycle. Similar injury in testosterone-treated transgenic mice resulted in amelioration of these effects. Similarly, there were increases in the levels of 4-hydroxy-2-hexenal-derived lipid peroxidation products in wild-type mice, which were also reduced in the transgenic mice. Similarly, necrosis of the S3 segment was reduced in the two injury models in transgenic mice compared to wild type. Our results suggest proximal tubule PPARα activity serves as a metabolic sensor. Its increased expression without the use of an exogenous PPARα ligand in the transgenic mice is sufficient to protect kidney function and morphology, and to prevent abnormalities in lipid metabolism associated with acute kidney injury. [ABSTRACT FROM AUTHOR]
AB - Copyright of Kidney International is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PEROXISOMAL disorders
KW - KIDNEY diseases
KW - TRANSGENIC mice
KW - DISEASES
KW - CISPLATIN
KW - KIDNEYS
KW - NECROSIS
KW - acute kidney injury
KW - cisplatin
KW - ischemia-reperfusion
KW - lipid peroxidation
KW - mitochondrial fatty acid oxidation
KW - PPARα
N1 - Accession Number: 44893213; Shenyang Li 1 Nagothu, Kiran K. 1 Desai, Varsha 2 Taewon Lee 3 Branham, William 2 Moland, Carrie 2 Megyesi, Judit K. 1 Crew, Mark D. 1 Portilla, Didier 1; Email Address: portilladidier@uams.edu; Affiliation: 1: Division of Nephrology, Departments of Internal Medicine and Immunology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA 2: Division of Systems Toxicology, Center for Functional Genomics, National Center for Toxicological Research, Jefferson, Arkansas, USA. 3: Department of Information and Mathematics, Korea University, Jochiwon, Chungnam, Korea.; Source Info: Nov2009, Vol. 76 Issue 10, p1049; Subject Term: PEROXISOMAL disorders; Subject Term: KIDNEY diseases; Subject Term: TRANSGENIC mice; Subject Term: DISEASES; Subject Term: CISPLATIN; Subject Term: KIDNEYS; Subject Term: NECROSIS; Author-Supplied Keyword: acute kidney injury; Author-Supplied Keyword: cisplatin; Author-Supplied Keyword: ischemia-reperfusion; Author-Supplied Keyword: lipid peroxidation; Author-Supplied Keyword: mitochondrial fatty acid oxidation; Author-Supplied Keyword: PPARα; Number of Pages: 14p; Illustrations: 3 Color Photographs, 2 Charts, 9 Graphs; Document Type: Article
L3 - 10.1038/ki.2009.330
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44893213&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Mathis, Lisa L.
AU - Pica-Branco, Denise
AU - Tassinari, Melissa S.
T1 - Improving Access to FDA Reviews and Documents.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/11/25/
VL - 302
IS - 20
M3 - Letter
SP - 2204
EP - 2205
SN - 00987484
AB - A letter to the editor is presented in response to the article "The Need for Improved Access to FDA Reviews," by A. B. O'Connor in a 2009 issue.
KW - LETTERS to the editor
KW - CLINICAL trials
N1 - Accession Number: 45468610; Mathis, Lisa L. 1; Email Address: lisa.mathis@fda.hhs.gov Pica-Branco, Denise 1 Tassinari, Melissa S. 1; Affiliation: 1: US Food and Drug Administration, Silver Spring, Maryland; Source Info: 11/25/2009, Vol. 302 Issue 20, p2204; Subject Term: LETTERS to the editor; Subject Term: CLINICAL trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lugovtsev, Vladimir Y.
AU - Smith, David F.
AU - Weir, Jerry P.
T1 - Changes of the receptor-binding properties of influenza B virus B/Victoria/504/2000 during adaptation in chicken eggs
JO - Virology
JF - Virology
Y1 - 2009/11/25/
VL - 394
IS - 2
M3 - Article
SP - 218
EP - 226
SN - 00426822
AB - Abstract: Selection of high-growth virus variants of strain B/Victoria/504/2000 by serial passage in eggs resulted in three amino acid substitutions, G141E, R162M, and D196Y, in the vicinity of the receptor-binding pocket of viral hemagglutinin. Virus variants containing the identified amino acid substitutions, individually or in various combinations, were constructed using reverse genetics and analyzed for their receptor-binding properties using glycan microarray platform. Three different patterns of virus binding were revealed. A low-growth virus variant, corresponding to the original egg-derived virus B/Victoria/504/2000 prior to acquisition of amino acid changes G141E, R162M, and D196Y, had a clear preference for the oligosaccharide chains terminated with α2-6-linked sialic acid with very weak binding of the glycans terminated with α2-3-linked sialic acid. Amino acid substitutions R162M and D196Y had similar effects, resulting in viruses that bound with high efficiency almost all terminally sialylated glycans represented on the array regardless of the type of glycosidic linkage. In contrast, substitution of G141E alone, or in combinations with the other two amino acid substitutions, significantly restricted virus glycan-binding capabilities. All virus variants possessing this substitution lost the ability to bind glycans with α2-6 glycosidic linkage as well as most of the glycans with α2-3 glycosidic linkage. Linear penta- and heptasaccharide chains represented at the non-reducing end by α2-3 sialylated Type-II motif (LacNAc) were the only structures bound with high affinity by the virus variants with G141E substitution. In all cases when the effects on virus binding of individual amino acid substitutions differed, the effect of R162M was subordinate to the effect of either G141E or D196Y. [Copyright &y& Elsevier]
AB - Copyright of Virology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOLIGAND assay
KW - INFLUENZA B virus
KW - AMINO acid sequence
KW - HEMAGGLUTININ
KW - VIRAL genetics
KW - OLIGOSACCHARIDES
KW - Egg adaptation, Glycan array
KW - Influenza B virus
KW - Receptor binding
N1 - Accession Number: 45302027; Lugovtsev, Vladimir Y. 1; Email Address: vladimir.lugovtsev@fda.hhs.gov Smith, David F. 2 Weir, Jerry P. 1; Affiliation: 1: Laboratory of Respiratory Viruses, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bldg. 29A, Room 2B17, Bethesda, MD 20892, USA 2: Consortium for Functional Glycomics Core H and Emory University School of Medicine, Department of Biochemistry, O. Wayne Rollins Research Center, 1510 Clifton Road NE, Atlanta, GA 30322, USA; Source Info: Nov2009, Vol. 394 Issue 2, p218; Subject Term: RADIOLIGAND assay; Subject Term: INFLUENZA B virus; Subject Term: AMINO acid sequence; Subject Term: HEMAGGLUTININ; Subject Term: VIRAL genetics; Subject Term: OLIGOSACCHARIDES; Author-Supplied Keyword: Egg adaptation, Glycan array; Author-Supplied Keyword: Influenza B virus; Author-Supplied Keyword: Receptor binding; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.virol.2009.08.014
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45302027&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Woodcock, Janet
T1 - A Difficult Balance — Pain Management, Drug Safety, and the FDA.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/11/26/
VL - 361
IS - 22
M3 - Opinion
SP - 2105
EP - 2107
SN - 00284793
AB - The author reflects on the issues surrounding pain management, drug safety and the rules of the U.S. Food and Drug Administration (FDA). She describes pain as a relevant aspect of a therapeutic goal. However, she claims that due to the risks associated with the use of nonsteroidal anti-inflammatory drugs (NSAID), acetaminophen, opioid and other pain relievers, FDA has been implementing rules to ensure safe and effective use of such drugs, which have negative effects on pain management.
KW - PAIN management
KW - ANALGESICS
KW - ACETAMINOPHEN
KW - OPIOIDS
KW - DRUGS -- Effectiveness
KW - THERAPEUTIC use
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 45515720; Woodcock, Janet 1; Affiliation: 1: Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 11/26/2009, Vol. 361 Issue 22, p2105; Subject Term: PAIN management; Subject Term: ANALGESICS; Subject Term: ACETAMINOPHEN; Subject Term: OPIOIDS; Subject Term: DRUGS -- Effectiveness; Subject Term: THERAPEUTIC use; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 3p; Illustrations: 2 Diagrams; Document Type: Opinion; Full Text Word Count: 1507
L3 - 10.1056/NEJMp0908913
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105252364
T1 - A difficult balance -- pain management, drug safety, and the FDA.
AU - Woodcock J
Y1 - 2009/11/26/
N1 - Accession Number: 105252364. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Analgesics -- Adverse Effects
KW - Analgesics -- Poisoning
KW - Analgesics -- Therapeutic Use
KW - Drug and Narcotic Control -- Legislation and Jurisprudence
KW - Pain -- Drug Therapy
KW - Acetaminophen -- Poisoning
KW - Acetaminophen -- Therapeutic Use
KW - Policy Making
KW - Analgesics, Opioid -- Adverse Effects
KW - Analgesics, Opioid -- Poisoning
KW - Analgesics, Opioid -- Therapeutic Use
KW - Overdose -- Epidemiology
KW - United States
KW - United States Food and Drug Administration
SP - 2105
EP - 2107
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 361
IS - 22
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD.
U2 - PMID: 19940297.
DO - 10.1056/NEJMp0908913
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105252364&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Kawamoto, M.
AU - Durgam, S.
AU - Eisenberg, J.
AU - Caldwell, K.
T1 - Pseudo-Outbreak of Antimony Toxicity in Firefighters -- Florida, 2009.
JO - MMWR: Morbidity & Mortality Weekly Report
JF - MMWR: Morbidity & Mortality Weekly Report
Y1 - 2009/11/27/
VL - 58
IS - 46
M3 - Article
SP - 1300
EP - 1302
PB - Centers for Disease Control & Prevention (CDC)
SN - 01492195
AB - The article analyzes the findings of the U.S. Centers for Disease Control and Prevention (CDC) about the antimony exposure on firefighters in Florida. The study of CDC in 2009 revealed that wearing pants made from antimony-containing fabric was not associated with elevated levels of urinary antinomy. The center assessed questionnaires and examined urine samples from two groups of firefighters, one who did not wear pants made from antimony-containing fabric and the other group did.
KW - ANTIMONY
KW - SURVEYS
KW - FIRE fighters -- Health
KW - TEXTILES
KW - URINALYSIS
KW - FLORIDA
KW - CENTERS for Disease Control & Prevention (U.S.)
N1 - Accession Number: 45545986; Kawamoto, M. 1 Durgam, S. 1 Eisenberg, J. 1 Caldwell, K. 2; Affiliation: 1: Div of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health 2: Div of Laboratory Sciences, National Center for Environmental Health; M de Perio, MD, EIS Officer, CDC; Source Info: 11/27/2009, Vol. 58 Issue 46, p1300; Subject Term: ANTIMONY; Subject Term: SURVEYS; Subject Term: FIRE fighters -- Health; Subject Term: TEXTILES; Subject Term: URINALYSIS; Subject Term: FLORIDA; Company/Entity: CENTERS for Disease Control & Prevention (U.S.); NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 923120 Administration of Public Health Programs; NAICS/Industry Codes: 313210 Broadwoven Fabric Mills; NAICS/Industry Codes: 314999 All Other Miscellaneous Textile Product Mills; NAICS/Industry Codes: 414130 Piece goods, notions and other dry goods merchant wholesalers; NAICS/Industry Codes: 424310 Piece Goods, Notions, and Other Dry Goods Merchant Wholesalers; Number of Pages: 3p; Illustrations: 1 Chart; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rupprecht, Charles E.
AU - Briggs, Deborah
AU - Brown, Catherine M.
AU - Franka, Richard
AU - Katz, Samuel L.
AU - Kerr, Harry D.
AU - Lett, Susan
AU - Levis, Robin
AU - Meltzer, Martin I.
AU - Schaffner, William
AU - Cieslak, Paul R.
T1 - Evidence for a 4-dose vaccine schedule for human rabies post-exposure prophylaxis in previously non-vaccinated individuals
JO - Vaccine
JF - Vaccine
Y1 - 2009/11/27/
VL - 27
IS - 51
M3 - Article
SP - 7141
EP - 7148
SN - 0264410X
AB - Abstract: After exposure, human rabies is preventable by prompt application of post-exposure prophylaxis. Historically, the total number of rabies vaccine doses administered during human prophylaxis has decreased, as modern biologics have improved and scientific knowledge has grown. A review of the literature on rabies virus pathogenesis, experimental animal studies, clinical trials, epidemiological surveillance, and economic analyses was conducted to determine the potential utility of reducing the current 5-dose intramuscular series of human rabies vaccine administered in the United States. Based upon the available evidence, a reduced schedule of cell-culture rabies vaccine, administered on days 0, 3, 7, and 14, given in conjunction with rabies immune globulin, was supported and recommended by the United States Advisory Committee on Immunization Practices. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Animal models in research
KW - Globulins
KW - Dosage of drugs
KW - Rabies
KW - Administration of drugs
KW - Rabies virus
KW - Clinical trials
KW - Medical literature
KW - Cell culture
KW - Post-exposure prophylaxis
KW - Rabies
KW - Reduced vaccination schedules
N1 - Accession Number: 45420545; Rupprecht, Charles E. 1; Email Address: cyr5@cdc.gov; Briggs, Deborah 2; Brown, Catherine M. 3; Franka, Richard 1; Katz, Samuel L. 4; Kerr, Harry D. 5; Lett, Susan 3; Levis, Robin 6; Meltzer, Martin I. 7; Schaffner, William 8; Cieslak, Paul R. 9; Affiliations: 1: National Center for Zoonotic, Vector-Borne and Enteric Diseases, 1600 Clifton Road, N.E., MS G33, Atlanta, GA 30333, United States; 2: Kansas State University, United States; 3: Massachusetts Department of Public Health, Jamaica Plain, MA, United States; 4: Duke University Medical Center, Durham, NC, United States; 5: American College of Emergency Physicians, Dallas, TX, United States; 6: Food and Drug Administration, Washington, DC, United States; 7: National Center for Preparedness, Detection, and Control of Infectious Diseases, CDC, United States; 8: Vanderbilt University School of Medicine, Nashville, TN, United States; 9: Oregon Department of Public Health, Corvallis, OR, United States; Issue Info: Nov2009, Vol. 27 Issue 51, p7141; Thesaurus Term: VACCINATION; Thesaurus Term: Animal models in research; Thesaurus Term: Globulins; Subject Term: Dosage of drugs; Subject Term: Rabies; Subject Term: Administration of drugs; Subject Term: Rabies virus; Subject Term: Clinical trials; Subject Term: Medical literature; Subject Term: Cell culture; Author-Supplied Keyword: Post-exposure prophylaxis; Author-Supplied Keyword: Rabies; Author-Supplied Keyword: Reduced vaccination schedules; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.09.029
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Sattler, Andrew C.
AU - Krogwold, Roger A.
AU - Wittum, Thomas E.
AU - Rupprecht, Charles E.
AU - Algeo, Timothy P.
AU - Slate, Dennis
AU - Smith, Kathleen A.
AU - Hale, Robert L.
AU - Nohrenberg, Gary A.
AU - Lovell, Charles D.
AU - Niezgoda, Mike
AU - Montoney, Andrew J.
AU - Slemons, Richard D.
T1 - Influence of oral rabies vaccine bait density on rabies seroprevalence in wild raccoons
JO - Vaccine
JF - Vaccine
Y1 - 2009/11/27/
VL - 27
IS - 51
M3 - Article
SP - 7187
EP - 7193
SN - 0264410X
AB - Abstract: The effect of different oral rabies vaccine (ORV) bait densities (75, 150, and 300baits/km2) on the seroprevalence of rabies virus neutralizing antibodies (RVNAs) in raccoons (Procyon lotor) was assessed at a 15% seroprevalence difference threshold in rural areas of northeast Ohio. Results (n =588 raccoons) indicated that seropositivity for RVNAs was associated with both bait density and bait campaign frequency. Associations were not detected for raccoon gender, age, or macro-habitat. The odds of being seropositive were greater for raccoons originating from 300bait/km2 treatment areas relative to those coming from the 75bait/km2 areas (odds ratio [OR]=4.4, probability [P]<0.001, 95% confidence interval [CI]=2.4–7.9), while accounting for cumulative ORV campaigns. No statistical advantage in seroprevalence was detected when comparing 150–75baits/km2. These results indicate that a relatively extreme bait density when evenly distributed may be necessary to obtain a significant increase in seroprevalence. Higher bait densities may be more appropriate and less costly to address focused outbreaks than labor intensive trap-vaccinate-release and local population reduction campaigns. Finally, dramatic increases in seroprevalence of RVNA were not observed in raccoons between sequential, semi-annual campaigns, yet cumulative ORV campaigns were associated with gradual increases in seroprevalence. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Raccoon
KW - Rabies
KW - Oral vaccines
KW - Seroprevalence
KW - Rabies virus
KW - Drugs -- Physiological effect
KW - Viral antibodies
KW - Oral rabies vaccine
KW - Rabies
N1 - Accession Number: 45420552; Sattler, Andrew C. 1,2; Krogwold, Roger A. 3; Wittum, Thomas E. 2; Rupprecht, Charles E. 4; Algeo, Timothy P. 5; Email Address: timothy.p.algeo@aphis.usda.gov; Slate, Dennis 5; Smith, Kathleen A. 6; Hale, Robert L. 7; Nohrenberg, Gary A. 8; Lovell, Charles D. 9; Niezgoda, Mike 4; Montoney, Andrew J. 9; Slemons, Richard D. 2; Affiliations: 1: All Creatures Animal Hospital, Puyallup, WA 98371, USA; 2: Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA; 3: USDA, APHIS, Veterinary Services, Pickerington, OH, 43147, USA; 4: US Department of Health and Human Services, Centers for Disease Control and Prevention, Rabies Unit, Atlanta, GA 30333, USA; 5: USDA, APHIS, Wildlife Services National Rabies Management Program, Concord, NH 03301-5786, USA; 6: Ohio Department of Health, Columbus, OH 43266, USA; 7: USDA, APHIS, Wildlife Services, National Rabies Management Program, Reynoldsburg, OH 43068, USA; 8: USDA, APHIS, Wildlife Services, St. Paul, MN 55107, USA; 9: USDA, APHIS, Wildlife Services, Reynoldsburg, OH 43068, USA; Issue Info: Nov2009, Vol. 27 Issue 51, p7187; Thesaurus Term: VACCINATION; Thesaurus Term: Raccoon; Subject Term: Rabies; Subject Term: Oral vaccines; Subject Term: Seroprevalence; Subject Term: Rabies virus; Subject Term: Drugs -- Physiological effect; Subject Term: Viral antibodies; Author-Supplied Keyword: Oral rabies vaccine; Author-Supplied Keyword: Rabies; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.09.035
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Kagan, Valerian E.
AU - Wipf, Peter
AU - Stoyanovsky, Detcho
AU - Greenberger, Joel S.
AU - Borisenko, Grigory
AU - Belikova, Natalia A.
AU - Yanamala, Naveena
AU - Samhan Arias, Alejandro K.
AU - Tungekar, Muhammad A.
AU - Jiang, Jianfei
AU - Tyurina, Yulia Y.
AU - Ji, Jing
AU - Klein-Seetharaman, Judith
AU - Pitt, Bruce R.
AU - Shvedova, Anna A.
AU - Bayır, Hülya
T1 - Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
Y1 - 2009/11/30/
VL - 61
IS - 14
M3 - Article
SP - 1375
EP - 1385
SN - 0169409X
AB - Abstract: Effective regulation of highly compartmentalized production of reactive oxygen species and peroxidation reactions in mitochondria requires targeting of small molecule antioxidants and antioxidant enzymes into the organelles. This review describes recently developed approaches to mitochondrial targeting of small biologically active molecules based on: (i) preferential accumulation in mitochondria because of their hydrophobicity and positive charge (hydrophobic cations), (ii) binding with high affinity to an intra-mitochondrial constituent, and (iii) metabolic conversions by specific mitochondrial enzymes to reveal an active entity. In addition, targeted delivery of antioxidant enzymes via expression of leader sequences directing the proteins into mitochondria is considered. Examples of successful antioxidant and anti-apoptotic protection based on the ability of targeted cargoes to inhibit cytochrome c-catalyzed peroxidation of a mitochondria-specific phospholipid cardiolipin, in vitro and in vivo are presented. Particular emphasis is placed on the employment of triphenylphosphonium- and hemi-gramicidin S-moieties as two effective vehicles for mitochondrial delivery of antioxidants. [Copyright &y& Elsevier]
AB - Copyright of Advanced Drug Delivery Reviews is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MITOCHONDRIA
KW - ANTIOXIDANTS
KW - DRUG targeting
KW - PHYSIOLOGICAL oxidation
KW - PROTEIN binding
KW - PEROXIDATION
KW - CYTOCHROME c
KW - APOPTOSIS
KW - Apoptosis
KW - Cardiolipin
KW - Cytochrome c
KW - Gramicidin S-conjugates
KW - Mitochondria
KW - MnSOD
KW - Nitroxides
KW - Peroxidation
KW - Triphenylphosphonium
N1 - Accession Number: 45214823; Kagan, Valerian E. 1,2; Email Address: kagan@pitt.edu Wipf, Peter 3 Stoyanovsky, Detcho 1,2 Greenberger, Joel S. 4 Borisenko, Grigory 5 Belikova, Natalia A. 1,2 Yanamala, Naveena 6 Samhan Arias, Alejandro K. 1,2 Tungekar, Muhammad A. 1,2 Jiang, Jianfei 1,2 Tyurina, Yulia Y. 1,2 Ji, Jing 7 Klein-Seetharaman, Judith 6 Pitt, Bruce R. 2 Shvedova, Anna A. 8 Bayır, Hülya 1,7; Affiliation: 1: Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA 2: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA 3: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA 4: Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15232, USA 5: Institute of Physico-Chemical Medicine, Moscow, 119992, Russia 6: Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA 7: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15201, USA 8: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, WV, 26505, USA; Source Info: Nov2009, Vol. 61 Issue 14, p1375; Subject Term: MITOCHONDRIA; Subject Term: ANTIOXIDANTS; Subject Term: DRUG targeting; Subject Term: PHYSIOLOGICAL oxidation; Subject Term: PROTEIN binding; Subject Term: PEROXIDATION; Subject Term: CYTOCHROME c; Subject Term: APOPTOSIS; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Cardiolipin; Author-Supplied Keyword: Cytochrome c; Author-Supplied Keyword: Gramicidin S-conjugates; Author-Supplied Keyword: Mitochondria; Author-Supplied Keyword: MnSOD; Author-Supplied Keyword: Nitroxides; Author-Supplied Keyword: Peroxidation; Author-Supplied Keyword: Triphenylphosphonium; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.addr.2009.06.008
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105260958
T1 - Eltrombopag for the treatment of chronic immune (idiopathic) thrombocytopenic purpura.
AU - Dmytrijuk A
AU - Robie-Suh K
AU - Rieves D
AU - Pazdur R
Y1 - 2009/11/30/
N1 - Accession Number: 105260958. Language: English. Entry Date: 20100205. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Commentary: Bussel JB. The Dmytrijuk/Robie-Suh/Rieves et al article reviewed. Update on eltrombopag for ITP. (ONCOLOGY (08909091)) Nov2009; 23 (13): 1177-1178. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Oncologic Care. NLM UID: 8712059.
KW - Growth Substances -- Therapeutic Use
KW - Purpura, Thrombocytopenic -- Complications
KW - Thrombocytopenia -- Drug Therapy
KW - Clinical Trials -- Evaluation
KW - Drug Approval
KW - Education, Continuing (Credit)
KW - Growth Substances -- Adverse Effects
KW - Secondary Analysis
KW - United States Food and Drug Administration
SP - 1171
EP - 1177
JO - Oncology (08909091)
JF - Oncology (08909091)
JA - ONCOLOGY (08909091)
VL - 23
IS - 13
CY - Norwalk, Connecticut
PB - UBM Medica
AB - Purpose: On November 20, 2008, eltrombopag (Promacta) received approval from the US Food and Drug Administration (FDA) for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. This report summarizes the FDA analyses of the clinical data supporting this approval.Experimental Design: The FDA reviewed data from two double-blind, placebo-controlled clinical studies, an uncontrolled extension study, and exploratory supportive studies. One study randomized patients among placebo or one of three daily doses of eltrombopag (30, 50, or 75 mg). The other study randomized patients between placebo or eltrombopag, 50 mg daily. Study drugs were administered for 6 weeks. The primary endpoint was response rate. Patients who completed these and other studies were eligible to enroll in the extension study.Results: Overall, 231 patients were randomized within the two controlled studies (67 to placebo; 164 to eltrombopag). A platelet response was observed among 59% and 70% of the patients receiving eltrombopag, 50 mg daily. Corresponding placebo response rates were 16% and 11%, respectively. Serious hemorrhages occurred among two patients receiving eltrombopag and one patient receiving placebo, and among five patients following discontinuation of eltrombopag. In the extension study, eltrombopag was administered to 109 patients; median platelet counts were > 50 x 109/L throughout the study's quarterly follow-up points. Major safety findings pertained to a risk for hepatotoxicity, worsened thrombocytopenia with hemorrhage following eltrombopag discontinuation, and bone marrow reticulin formation.Conclusions: The US FDA approved eltrombopag for use among certain patients with chronic ITP based upon demonstration of a favorable risk-to-benefit profile, where the major benefit pertained to demonstration of a clinically important increase in blood platelets among a population of patients relatively refractory to prior therapies.
SN - 0890-9091
AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland
U2 - PMID: 20043468.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105259969
T1 - Screening for lipid disorders in adults.
AU - Lin KW
Y1 - 2009/12//12/1/2009
N1 - Accession Number: 105259969. Language: English. Entry Date: 20100129. Revision Date: 20150711. Publication Type: Journal Article; case study. Journal Subset: Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 1272646.
KW - Blacks
KW - Hyperlipidemia -- Diagnosis
KW - Obesity
KW - Female
KW - Hyperlipidemia -- Ethnology
KW - Middle Age
KW - Risk Factors
SP - 1281
EP - 1281
JO - American Family Physician
JF - American Family Physician
JA - AM FAM PHYSICIAN
VL - 80
IS - 11
CY - Skokie, Illinois
PB - American Academy of Family Physicians
SN - 0002-838X
AD - Agency for Healthcare Research and Quality, Bethesda, MA, USA
U2 - PMID: 19961141.
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Duan, Shaojin
AU - Gu, Lizhen
AU - Wang, Yanyun
AU - Zheng, Rongbo
AU - Lu, Jingfen
AU - Yin, Junjie
AU - Guli, Laowa
AU - Ball, Michele
T1 - Regulation of Influenza Virus-Caused Oxidative Stress by Kegan Liyan Oral Prescription, as Monitored by Ascorbyl Radical ESR Signals.
JO - American Journal of Chinese Medicine
JF - American Journal of Chinese Medicine
Y1 - 2009/12//
VL - 37
IS - 6
M3 - Article
SP - 1167
EP - 1177
PB - World Scientific Publishing Company
SN - 0192415X
AB - To study the oxidative stress level of the influenza virus A FM1 subset-infected mouse in intranasal inhalation as a model, we employ an ascorbyl radical's ESR (electron spin resonance) spectrum as an oxidative stress biomarker. These infected mice were pretreated with Ribavirin, ascorbic acid, superoxide dismutase (SOD) or Kegan Liyan oral prescription (KGLY, proprietary Chinese medicine for influenza and common cold) in the stomach tube for 3 days, and then followed by the virus-infecting for 4 days. On the 4th day, samples were collected. It is recognized the strength of ascorbyl radical's ESR signal (A-.) (aH4 = 0.177 Gauss, g = 2.00517) denotes oxidative stress level in vivo and in vitro. The magnitude of ESR spectrum (28.65 ± 10.71 AU) in mice infected with influenza virus was significantly higher than those of healthy control mice (19.10 ± 3.61 AU). Serum A-. in mice treated with Ribavirin, ascorbic acid, SOD and KGLY declined to 19.70 ± 6.05, 18.50 ± 2.93 and 16.25 ± 3.59, 18.40 ± 2.14 AU respectively. It is close to A-. signal height in healthy controls via down-regulation of the influenza virus-caused oxidative stress level getting decline in the lung index of pneumonia as compare to those of untreated healthy and the influenza virus infected mice pneumonia. It is well known that SOD can prevent the influenza virus pneumonia enhancing mouse survival rate; Ribavirin can treat viral diseases. Data from this study suggested that KGLY may indirectly relieve influenza virus-infected pneumonia via down- regulation of virus caused oxidative stress coupled with a redox reaction cascade as ribavirin, ascorbic acid and SOD. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OXIDATIVE stress
KW - INFLUENZA viruses
KW - MICE as laboratory animals
KW - ELECTRON paramagnetic resonance
KW - RIBAVIRIN
KW - Antioxidant
KW - Flos Lonicerae
KW - Influenza Virus
KW - Kegan Liyan
KW - Oxidative Stress
KW - Radix
KW - Radix Glycyrrhizae
KW - Scutellariae
N1 - Accession Number: 45391333; Duan, Shaojin 1; Email Address: shaojduan@yahoo.com Gu, Lizhen 1 Wang, Yanyun 1 Zheng, Rongbo 2 Lu, Jingfen 3 Yin, Junjie 4 Guli, Laowa 3 Ball, Michele 5; Affiliation: 1: Department of Basic Medicine, Guang An Men Hospital, Beijing 100053, China 2: Guangzhou WangLaoJi Pharmaceutical Company Limited, Guangzhou 510450, China 3: National Laboratory of Natural and Biomimetic Drugs, Health Sciences, Center of Peking University, Beijing 100083, China 4: Center for Food Safety and Applied Nutrition, FDA, College Park, MD 20740, USA 5: Graduate School, China Academy of Chinese Medical Sciences, Beijing 100053, China; Source Info: 2009, Vol. 37 Issue 6, p1167; Subject Term: OXIDATIVE stress; Subject Term: INFLUENZA viruses; Subject Term: MICE as laboratory animals; Subject Term: ELECTRON paramagnetic resonance; Subject Term: RIBAVIRIN; Author-Supplied Keyword: Antioxidant; Author-Supplied Keyword: Flos Lonicerae; Author-Supplied Keyword: Influenza Virus; Author-Supplied Keyword: Kegan Liyan; Author-Supplied Keyword: Oxidative Stress; Author-Supplied Keyword: Radix; Author-Supplied Keyword: Radix Glycyrrhizae; Author-Supplied Keyword: Scutellariae; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 11p; Illustrations: 3 Diagrams, 2 Charts, 2 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mei Lin Wang
AU - Avashia, Bipin H.
AU - Wood, John
AU - Petsonk, Edward L.
T1 - Excessive Longitudinal FEV1 Decline and Risks to Future Health: A Case-Control Study.
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
Y1 - 2009/12//
VL - 52
IS - 12
M3 - Article
SP - 909
EP - 915
SN - 02713586
AB - The article presents a study which explores the long-term risk for adverse health outcomes among individuals who are suffering from accelerated lung function declines. In this study, chemical plant workers' accelerated loss of forced expiratory volume in 1 s (FEV1) were calculated by simple linear regression. Result shows that those workers with accelerated (FEV1) losses sustained four to nine times as many adverse health conditions after 10-30 years.
KW - HEALTH
KW - Health
KW - Lung diseases
KW - Chemical workers
KW - Regression analysis
KW - Respiratory measurements
KW - chronic obstructive
KW - excessive FEV1 decline
KW - mass screening
KW - pulmonary disease
KW - spirometry
N1 - Accession Number: 45893663; Mei Lin Wang 1; Avashia, Bipin H. 2; Wood, John 1; Petsonk, Edward L. 1; Email Address: elp2@cdc.gov; Affiliations: 1: Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, West Virginia, USA; 2: Medical Department, Institute Plant, Institute, West Virginia, USA; Issue Info: Dec2009, Vol. 52 Issue 12, p909; Thesaurus Term: HEALTH; Thesaurus Term: Health; Subject Term: Lung diseases; Subject Term: Chemical workers; Subject Term: Regression analysis; Subject Term: Respiratory measurements; Author-Supplied Keyword: chronic obstructive; Author-Supplied Keyword: excessive FEV1 decline; Author-Supplied Keyword: mass screening; Author-Supplied Keyword: pulmonary disease; Author-Supplied Keyword: spirometry; Number of Pages: 7p; Document Type: Article
L3 - 10.1002/ajim.20764
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105270811
T1 - National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009.
AU - Edwards JR
AU - Peterson KD
AU - Mu Y
AU - Banerjee S
AU - Allen-Bridson K
AU - Morrell G
AU - Dudeck MA
AU - Pollock DA
AU - Horan TC
Y1 - 2009/12//
N1 - Accession Number: 105270811. Language: English. Entry Date: 20100212. Revision Date: 20150819. Publication Type: Journal Article; research; tables/charts. Journal Subset: Core Nursing; Nursing; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 8004854.
KW - Cross Infection -- Epidemiology
KW - Equipment and Supplies
KW - Acute Care
KW - Bacteremia
KW - Birth Weight
KW - Catheter-Related Infections
KW - Centers for Disease Control and Prevention (U.S.)
KW - Central Venous Catheters
KW - Cross Infection -- Diagnosis
KW - Descriptive Statistics
KW - Diagnosis, Laboratory
KW - Disease Surveillance
KW - Epidemiological Research
KW - Hospitals
KW - Infant, Newborn
KW - Inpatients
KW - Intensive Care Units
KW - Intensive Care Units, Neonatal
KW - Pneumonia, Ventilator-Associated
KW - Postoperative Complications
KW - Umbilical Arteries
KW - Urinary Tract Infections
SP - 783
EP - 805
JO - American Journal of Infection Control
JF - American Journal of Infection Control
JA - AM J INFECT CONTROL
VL - 37
IS - 10
CY - New York, New York
PB - Elsevier Science
SN - 0196-6553
AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA. JREdwards@cdc.gov
U2 - PMID: 20004811.
DO - 10.1016/j.ajic.2009.10.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105270811&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Carman, Robert J.
AU - Genheimer, Christopher W.
AU - Rafii, Fatemeh
AU - Park, Miseon
AU - Hiltonsmith, Megan F.
AU - Lyerly, David M.
T1 - Diversity of moxifloxacin resistance during a nosocomial outbreak of a predominantly ribotype ARU 027 Clostridium difficile diarrhea
JO - Anaerobe
JF - Anaerobe
Y1 - 2009/12//
VL - 15
IS - 6
M3 - Article
SP - 244
EP - 248
SN - 10759964
AB - Abstract: To characterize the extent and diversity of moxifloxacin resistance among Clostridium difficile isolates recovered during a predominantly Anaerobe Reference Unit (ARU) ribotype 027-associated nosocomial outbreak of antibiotic associated diarrhea we measured the susceptibility of 34 field isolates and 6 laboratory strains of C. difficile to moxifloxacin. We ribotyped the isolates as well as assaying them by PCR for the metabolic gene, gdh, and the virulence genes, tcdA, tcdB, tcdC, cdtA and cdtB. All the laboratory isolates, including the historical ARU 027 isolate Cd196, were susceptible to moxifloxacin (≤2μg/mL). 13 field isolates were susceptible to ≤2μg/mL. Five were resistant to from 4 to 12μg/mL (moderate resistance); 16 were resistant to ≥16μg/mL (high resistance). We sequenced the quinolone resistance determining regions of gyrA (position 71-460) and gyrB (position 1059-1448) from two susceptible laboratory strains, all five isolates with moderate resistance and two highly resistant isolates. Two highly resistant isolates (Pitt 40, ribotype ARU 027 and Pitt 33, ribotype ARU 001) had the same C245T (Thr82ΔIle) mutation. No other changes were seen. Amplification with primer pairs specific for the C245T mutant gyrA and for the wild type gene respectively confirmed all 16 highly resistant ARU 027 isolates, as well as the highly resistant isolates from other ribotypes, had the C245T mutation and that the mutation was absent from all other isolates. Among the five isolates with moderate resistance we found combinations of mutations within gyrA (T128A, Val43ΔAsp and G349T, Ala117ΔSer) and gyrB (G1276A, Arg426ΔAsn). The G1396A (Glu466ΔLys) mutation was not associated with increased resistance. [Copyright &y& Elsevier]
AB - Copyright of Anaerobe is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MOXIFLOXACIN
KW - DRUG resistance
KW - CLOSTRIDIUM difficile
KW - DISEASE susceptibility
KW - POLYMERASE chain reaction
KW - QUINOLONE antibacterial agents
KW - Clostridium difficile
KW - gyrA
KW - gyrB
KW - MAMA
KW - Moxifloxacin
KW - PCR
KW - QRDR
KW - Quinolone
KW - Resistance
KW - SNP
N1 - Accession Number: 45560995; Carman, Robert J. 1; Email Address: rjcarman@techlab.com Genheimer, Christopher W. 1 Rafii, Fatemeh 2 Park, Miseon 2 Hiltonsmith, Megan F. 1 Lyerly, David M. 1; Affiliation: 1: TechLab Inc., 2001 Kraft Drive, Blacksburg, VA 24060-6358, USA 2: Division of Microbiology, FDA National Center for Toxicological Research, 3900 NCTR Road, HFT-1, Jefferson, AR 72079-9502, USA; Source Info: Dec2009, Vol. 15 Issue 6, p244; Subject Term: MOXIFLOXACIN; Subject Term: DRUG resistance; Subject Term: CLOSTRIDIUM difficile; Subject Term: DISEASE susceptibility; Subject Term: POLYMERASE chain reaction; Subject Term: QUINOLONE antibacterial agents; Author-Supplied Keyword: Clostridium difficile; Author-Supplied Keyword: gyrA; Author-Supplied Keyword: gyrB; Author-Supplied Keyword: MAMA; Author-Supplied Keyword: Moxifloxacin; Author-Supplied Keyword: PCR; Author-Supplied Keyword: QRDR; Author-Supplied Keyword: Quinolone; Author-Supplied Keyword: Resistance; Author-Supplied Keyword: SNP; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.anaerobe.2009.09.009
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45560995&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105263396
T1 - Good news for the US obesity epidemic.
AU - Clancy CM
Y1 - 2009/12//
N1 - Accession Number: 105263396. Language: English. Entry Date: 20100129. Revision Date: 20150818. Publication Type: Journal Article. Journal Subset: Core Nursing; Double Blind Peer Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed; USA. Special Interest: Perioperative Care. NLM UID: 0372403.
KW - Bariatric Surgery
KW - Obesity -- Epidemiology -- United States
KW - Obesity -- Surgery
KW - Surgery, Laparoscopic
KW - Postoperative Complications -- Epidemiology
KW - Treatment Outcomes
KW - United States
SP - 905
EP - 907
JO - AORN Journal
JF - AORN Journal
JA - AORN J
VL - 90
IS - 6
CY - Philadelphia, Pennsylvania
PB - Elsevier Inc.
SN - 0001-2092
AD - Agency for Healthcare Research and Quality.
U2 - PMID: 19961976.
DO - 10.1016/j.aorn.2009.11.036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105263396&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Vo, Evanly
AU - Rengasamy, Samy
AU - Shaffer, Ronald
T1 - Development of a Test System To Evaluate Procedures for Decontamination of Respirators Containing Viral Droplets.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/12//
VL - 75
IS - 23
M3 - Article
SP - 7303
EP - 7309
SN - 00992240
AB - The aim of this study was to develop a test system to evaluate the effectiveness of procedures for decontamination of respirators contaminated with viral droplets. MS2 coliphage was used as a surrogate for pathogenic viruses. A viral droplet test system was constructed, and the size distribution of viral droplets loaded directly onto respirators was characterized using an aerodynamic particle sizer. The sizes ranged from 0.5 to 15 μm, and the sizes of the majority of the droplets were the range from 0.74 to 3.5 μm. The results also showed that the droplet test system generated similar droplet concentrations (particle counts) at different respirator locations. The test system was validated by studying the relative efficiencies of decontamination of sodium hypochlorite (bleach) and UV irradiation with droplets containing MS2 virus on filtering facepiece respirators. It was hypothesized that more potent decontamination treatments would result in corresponding larger decreases in the number of viable viruses recovered from the respirators. Sodium hypochlorite doses of 2.75 to 5.50 mg/liter with a 10-min decontamination period resulted in approximately 3- to 4-log reductions in the level of MS2 coliphage. When higher sodium hypochlorite doses (≥8.25 mg/liter) were used with the same contact time that was used for the dilute solutions containing 2.75 to 5.50 mg/liter, all MS2 was inactivated. For UV decontamination at a wavelength of 254 nm, an approximately 3-log reduction in the level of MS2 virus was achieved with dose of 4.32 J/cm2 (3 h of contact time with a UV intensity of 0.4 mW/cm2), while with higher doses of UV irradiation (≥7.20 J/cm2; UV intensity, 0.4 mW/cm2; contact times, ≥5 h), all MS2 was inactivated. These findings may lead to development of a standard method to test decontamination of respirators challenged by viral droplets. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOACTIVE decontamination
KW - RESPIRATORS (Medical equipment)
KW - BACTERIOPHAGES
KW - PHYSIOLOGY
KW - VIRAL antigens
KW - DYNAMICS of a particle
KW - PARTICULATE matter
KW - ULTRAVIOLET radiation
KW - IRRADIATION
KW - SODIUM hypochlorite
KW - ARTIFICIAL respiration
N1 - Accession Number: 47080445; Vo, Evanly 1 Rengasamy, Samy 1 Shaffer, Ronald 1; Email Address: RShaffer@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236; Source Info: Dec2009, Vol. 75 Issue 23, p7303; Subject Term: RADIOACTIVE decontamination; Subject Term: RESPIRATORS (Medical equipment); Subject Term: BACTERIOPHAGES; Subject Term: PHYSIOLOGY; Subject Term: VIRAL antigens; Subject Term: DYNAMICS of a particle; Subject Term: PARTICULATE matter; Subject Term: ULTRAVIOLET radiation; Subject Term: IRRADIATION; Subject Term: SODIUM hypochlorite; Subject Term: ARTIFICIAL respiration; NAICS/Industry Codes: 334517 Irradiation Apparatus Manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 334510 Electromedical and Electrotherapeutic Apparatus Manufacturing; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 1 Graph; Document Type: Article
L3 - 10.1128/AEM.00799-09
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47080445&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
AU - da Costa, Gonçalo Gamboa
AU - Camacho, Luisa
T1 - Comparison of the metabolic activities of four wild-type Clostridium perfringens strains with their gatifloxacin-selected resistant mutants.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2009/12//
VL - 191
IS - 12
M3 - Article
SP - 895
EP - 902
PB - Springer Science & Business Media B.V.
SN - 03028933
AB - The production of short-chain fatty acids, reductive enzymes, and hydrolytic enzymes by four gatifloxacin-selected, fluoroquinolone-resistant, mutant strains of C. perfringens, with stable mutations either in DNA gyrase or in both DNA gyrase and topoisomerase IV, was compared with that produced by the wild-type parent strains to investigate the effect of mutations associated with the selection of gatifloxacin resistance on bacterial metabolic activities. The mutants differed from their respective wild-type parent strains in the enzymatic activities of azoreductase, nitroreductase, and β-glucosidase and in the ratio of butyric acid to acetic acid production. Microarray analysis of one wild type and the corresponding mutant revealed different levels of mRNA expression for the enzymes involved in short-chain fatty acid (SCFA) synthesis and for β-glucosidase and oxidoreductases. In addition to mutations in the target genes, selection of resistance to gatifloxacin resulted in strain-specific physiological changes in the resistant mutants of C. perfringens that affected their metabolic activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Enzymology
KW - Mutation (Biology)
KW - Clostridium perfringens
KW - DNA topoisomerase II
KW - Messenger RNA
KW - Azoreductase
KW - Fluoroquinolone
KW - Gatifloxacin
KW - Nitroreductase
KW - Resistance
N1 - Accession Number: 45164885; Rafii, Fatemeh 1; Email Address: fatemeh.rafii@fda.hhs.gov; Park, Miseon 1; da Costa, Gonçalo Gamboa 2; Camacho, Luisa 2; Affiliations: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.; 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.; Issue Info: Dec2009, Vol. 191 Issue 12, p895; Thesaurus Term: Enzymology; Thesaurus Term: Mutation (Biology); Subject Term: Clostridium perfringens; Subject Term: DNA topoisomerase II; Subject Term: Messenger RNA; Author-Supplied Keyword: Azoreductase; Author-Supplied Keyword: Fluoroquinolone; Author-Supplied Keyword: Gatifloxacin; Author-Supplied Keyword: Nitroreductase; Author-Supplied Keyword: Resistance; Number of Pages: 8p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1007/s00203-009-0518-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45164885&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Rafii, Fatemeh
AU - Park, Miseon
AU - da Costa, Gonçalo Gamboa
AU - Camacho, Luisa
T1 - Comparison of the metabolic activities of four wild-type Clostridium perfringens strains with their gatifloxacin-selected resistant mutants.
JO - Archives of Microbiology
JF - Archives of Microbiology
Y1 - 2009/12//
VL - 191
IS - 12
M3 - Article
SP - 895
EP - 902
SN - 03028933
AB - The production of short-chain fatty acids, reductive enzymes, and hydrolytic enzymes by four gatifloxacin-selected, fluoroquinolone-resistant, mutant strains of C. perfringens, with stable mutations either in DNA gyrase or in both DNA gyrase and topoisomerase IV, was compared with that produced by the wild-type parent strains to investigate the effect of mutations associated with the selection of gatifloxacin resistance on bacterial metabolic activities. The mutants differed from their respective wild-type parent strains in the enzymatic activities of azoreductase, nitroreductase, and β-glucosidase and in the ratio of butyric acid to acetic acid production. Microarray analysis of one wild type and the corresponding mutant revealed different levels of mRNA expression for the enzymes involved in short-chain fatty acid (SCFA) synthesis and for β-glucosidase and oxidoreductases. In addition to mutations in the target genes, selection of resistance to gatifloxacin resulted in strain-specific physiological changes in the resistant mutants of C. perfringens that affected their metabolic activities. [ABSTRACT FROM AUTHOR]
AB - Copyright of Archives of Microbiology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CLOSTRIDIUM perfringens
KW - DNA topoisomerase II
KW - MESSENGER RNA
KW - ENZYMOLOGY
KW - MUTATION (Biology)
KW - Azoreductase
KW - Clostridium perfringens
KW - Fluoroquinolone
KW - Gatifloxacin
KW - Nitroreductase
KW - Resistance
N1 - Accession Number: 45164885; Rafii, Fatemeh 1; Email Address: fatemeh.rafii@fda.hhs.gov Park, Miseon 1 da Costa, Gonçalo Gamboa 2 Camacho, Luisa 2; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. 2: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.; Source Info: Dec2009, Vol. 191 Issue 12, p895; Subject Term: CLOSTRIDIUM perfringens; Subject Term: DNA topoisomerase II; Subject Term: MESSENGER RNA; Subject Term: ENZYMOLOGY; Subject Term: MUTATION (Biology); Author-Supplied Keyword: Azoreductase; Author-Supplied Keyword: Clostridium perfringens; Author-Supplied Keyword: Fluoroquinolone; Author-Supplied Keyword: Gatifloxacin; Author-Supplied Keyword: Nitroreductase; Author-Supplied Keyword: Resistance; Number of Pages: 8p; Illustrations: 2 Charts, 5 Graphs; Document Type: Article
L3 - 10.1007/s00203-009-0518-3
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45164885&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Chen, Fei
AU - Beezhold, Kevin
AU - Castranova, Vince
T1 - JNK1, a potential therapeutic target for hepatocellular carcinoma
JO - BBA - Reviews on Cancer
JF - BBA - Reviews on Cancer
Y1 - 2009/12//
VL - 1796
IS - 2
M3 - Article
SP - 242
EP - 251
SN - 0304419X
AB - Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite tremendous efforts to diagnose and institute new treatment regimens, the prognosis is still extremely poor. Therefore, knowledge of the molecular mechanisms governing the initiation, maintenance and progression of HCC is urgently needed. Recently, several groups have attributed an important role for c-Jun N-terminal kinase 1 (JNK1) in the pathogenesis of human HCC and its close association with the expression of HCC signature genes. In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease. [Copyright &y& Elsevier]
AB - Copyright of BBA - Reviews on Cancer is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LIVER -- Cancer
KW - DRUG targeting
KW - CANCER -- Mortality
KW - CANCER invasiveness
KW - PROTEIN kinases
KW - GENE expression
KW - CANCER -- Prognosis
KW - GENETIC aspects
KW - Epigenetics
KW - HCC
KW - JNK1
KW - Progenitor cells
KW - ROS
KW - Signature genes
N1 - Accession Number: 44417001; Chen, Fei; Email Address: lfd3@cdc.gov Beezhold, Kevin 1 Castranova, Vince 1; Affiliation: 1: Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA; Source Info: Dec2009, Vol. 1796 Issue 2, p242; Subject Term: LIVER -- Cancer; Subject Term: DRUG targeting; Subject Term: CANCER -- Mortality; Subject Term: CANCER invasiveness; Subject Term: PROTEIN kinases; Subject Term: GENE expression; Subject Term: CANCER -- Prognosis; Subject Term: GENETIC aspects; Author-Supplied Keyword: Epigenetics; Author-Supplied Keyword: HCC; Author-Supplied Keyword: JNK1; Author-Supplied Keyword: Progenitor cells; Author-Supplied Keyword: ROS; Author-Supplied Keyword: Signature genes; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.bbcan.2009.06.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44417001&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - van Eijsden, Manon
AU - Hornstra, Gerard
AU - van der Wal, Marcel F.
AU - Bonsel, Gouke J.
T1 - Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis.
JO - British Journal of Nutrition
JF - British Journal of Nutrition
Y1 - 2009/12//
VL - 101
IS - 12
M3 - Article
SP - 1761
EP - 1768
SN - 00071145
AB - Ethnicity-related differences in maternal n-3 and n-6 fatty acid status may be relevant to ethnic disparities in birth outcomes observed worldwide. The present study explored differences in early pregnancy n-3 and n-6 fatty acid composition of maternal plasma phospholipids between Dutch and ethnic minority pregnant women in Amsterdam, the Netherlands, with a focus on the major functional fatty acids EPA (20 : 5n-3), DHA (22 : 6n-3), dihomo-γ-linolenic acid (DGLA; 20 : 3n-6) and arachidonic acid (AA; 20 : 4n-6). Data were derived from the Amsterdam Born Children and their Development (ABCD) cohort (inclusion January 2003 to March 2004). Compared with Dutch women (n 2443), Surinamese (n 286), Antillean (n 63), Turkish (n 167) and Moroccan (n 241) women had generally lower proportions of n-3 fatty acids (expressed as percentage of total fatty acids) but higher proportions of n-6 fatty acids (general linear model; P < 0·001). Ghanaian women (n 54) had higher proportions of EPA and DHA, but generally lower proportions of n-6 fatty acids (P < 0·001). Differences were most pronounced in Turkish and Ghanaian women, who, by means of a simple questionnaire, reported the lowest and highest fish consumption respectively. Adjustment for fish intake, however, hardly attenuated the differences in relative EPA, DHA, DGLA and AA concentrations between the various ethnic groups. Given the limitations of this observational study, further research into the ethnicity-related differences in maternal n-3 and n-6 fatty acid patterns is warranted, particularly to elucidate the explanatory role of fatty acid intake v. metabolic differences. [ABSTRACT FROM PUBLISHER]
AB - Copyright of British Journal of Nutrition is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Amsterdam Born Children and their Development study
KW - Ethnic groups
KW - Long-chain polyunsaturated fatty acids
KW - Pregnancy
N1 - Accession Number: 56665829; van Eijsden, Manon 1,2; Hornstra, Gerard 3; van der Wal, Marcel F. 1; Bonsel, Gouke J. 4; Affiliations: 1: Department of Epidemiology, Documentation and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands; 2: Department of Social Medicine, Public Health Epidemiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; 3: Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; 4: The Institute Health Policy and Management, Erasmus Medical Centre, Rotterdam, The Netherlands; Issue Info: Dec2009, Vol. 101 Issue 12, p1761; Author-Supplied Keyword: Amsterdam Born Children and their Development study; Author-Supplied Keyword: Ethnic groups; Author-Supplied Keyword: Long-chain polyunsaturated fatty acids; Author-Supplied Keyword: Pregnancy; Number of Pages: 8p; Document Type: Article
L3 - 10.1017/S0007114508123455
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105381006
T1 - Ethnic differences in early pregnancy maternal n-3 and n-6 fatty acid concentrations: an explorative analysis.
AU - van Eijsden M
AU - Hornstra G
AU - van der Wal MF
AU - Bonsel GJ
Y1 - 2009/12//
N1 - Accession Number: 105381006. Language: English. Entry Date: 20100416. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Allied Health; Biomedical; Double Blind Peer Reviewed; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland. Special Interest: Nutrition; Obstetric Care; Women's Health. Grant Information: Netherlands Organisation for Health Research and Development (ZonMW), in The Hague, the Public Health Service and Municipal Council of Amsterdam, the Academic Medical Centre, and Nutricia Research BV in Zoetermeer. NLM UID: 0372547.
KW - Fatty Acids, Omega-3 -- Blood -- In Pregnancy
KW - Fatty Acids, Omega-6 -- Blood -- In Pregnancy
KW - Nutritional Status -- In Pregnancy -- Netherlands
KW - Race Factors -- In Pregnancy -- Netherlands
KW - Analysis of Variance
KW - Arachidonic Acids -- Blood -- In Pregnancy
KW - Body Mass Index -- In Pregnancy
KW - Chi Square Test
KW - Comparative Studies
KW - Data Analysis Software
KW - Descriptive Statistics
KW - Docosahexaenoic Acids -- Blood -- In Pregnancy
KW - Eicosapentaenoic Acid -- Blood -- In Pregnancy
KW - Exploratory Research
KW - Female
KW - Fetus
KW - Funding Source
KW - Ghana -- Ethnology
KW - Linolenic Acids -- Blood -- In Pregnancy
KW - Morocco -- Ethnology
KW - Netherlands
KW - Pregnancy
KW - Questionnaires
KW - Suriname -- Ethnology
KW - Turkey -- Ethnology
KW - West Indies -- Ethnology
KW - Women's Health
KW - Human
SP - 1761
EP - 1768
JO - British Journal of Nutrition
JF - British Journal of Nutrition
JA - BR J NUTR
VL - 101
IS - 12
PB - Cambridge University Press
SN - 0007-1145
AD - Department of Epidemiology, Documentation and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands. mveijsden@ggd.amsterdam.nl
U2 - PMID: 18983717.
DO - 10.1017/S0007114508123455
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105381006&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Goorhuis, A.
AU - Legaria, M. C.
AU - van den Berg, R. J.
AU - Harmanus, C.
AU - Klaassen, C. H. W.
AU - Brazier, J. S.
AU - Lumelsky, G.
AU - Kuijper, E. J.
T1 - Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina.
JO - Clinical Microbiology & Infection
JF - Clinical Microbiology & Infection
Y1 - 2009/12//
VL - 15
IS - 12
M3 - Article
SP - 1080
EP - 1086
PB - Elsevier Science
SN - 1198743X
AB - Isolates from patients with Clostridium difficile infection (CDI) usually produce both toxin A (TcdA) and toxin B (TcdB), but an increasing number of reports from Europe and Asia mention infections with TcdA-negative, TcdB-positive (A−/B+) strains, usually characterized as PCR ribotype 017 (type 017). Incidence rates of CDI per 10 000 admissions in a 200-bed Argentinean general hospital were 37, 84, 67, 43, 48 and 42 for the years 2000 to 2005, respectively. The annual percentages of type 017 CDI were 7.7%, 64.6%, 91.4%, 92.0%, 75.0% and 86.4%, respectively. Comparison of 112 017-CDI patients with 41 non-017-CDI patients revealed that 017-CDI patients were more often male (68.8% vs. 46.3%; odds ratio 2.55, 95% confidence interval 1.23–5.50). All type 017 strains tested belonged to toxinotype VIII and had a 1.8-kb deletion in tcdA. In addition, 90% of tested type 017 isolates had high-level resistance to clindamycin and erythromycin, determined by the presence of the ermB gene. Multiple-locus variable-number tandem-repeat analysis (MLVA) was applied to 56 Argentinean isolates and 15 isolates from seven other countries. Country-specific clonal complexes were found in each country. Among 56 Argentinean isolates, four clonal complexes were recognized, accounting for 61% of all isolates. These clonal complexes did not show correlation over time, but seemed to be restricted to specific wards, mainly internal medicine and pulmonology wards. A total of 56% of recurrent infections were caused by a different isolate, despite identification of an identical PCR-ribotype. We conclude that C. difficile type 017 gradually replaced other circulating PCR ribotypes and that MLVA provides detailed insight into nosocomial spread. [ABSTRACT FROM AUTHOR]
AB - Copyright of Clinical Microbiology & Infection is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Clostridium difficile
KW - Patients
KW - Buenos Aires (Argentina)
KW - Argentina
KW - Europe
KW - Asia
KW - Clonal spread
KW - MLVA
KW - PCR ribotype 017
KW - recurrences
KW - toxin A negative
KW - toxinotype VIII
N1 - Accession Number: 45132297; Goorhuis, A. 1; Legaria, M. C. 2; van den Berg, R. J. 1; Harmanus, C. 1; Klaassen, C. H. W. 3; Brazier, J. S. 4; Lumelsky, G. 2; Kuijper, E. J. 1; Email Address: e.j.kuijper@lumc.nl; Affiliations: 1: Department of Medical Microbiology, Leiden University Medical Centre, Leiden, The Netherlands.; 2: Unidad Microbiologia, Hospital General de Agudos 'E. Tornú', Combatientes de Malvinas, Buenos Aires, Argentina.; 3: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.; 4: Anaerobe Reference Laboratory, National Public Health Service Microbiology Cardiff, University Hospital of Wales, Cardiff, UK.; Issue Info: Dec2009, Vol. 15 Issue 12, p1080; Subject Term: Clostridium difficile; Subject Term: Patients; Subject: Buenos Aires (Argentina); Subject: Argentina; Subject: Europe; Subject: Asia; Author-Supplied Keyword: Clonal spread; Author-Supplied Keyword: MLVA; Author-Supplied Keyword: PCR ribotype 017; Author-Supplied Keyword: recurrences; Author-Supplied Keyword: toxin A negative; Author-Supplied Keyword: toxinotype VIII; Number of Pages: 7p; Illustrations: 2 Diagrams, 2 Charts; Document Type: Article
L3 - 10.1111/j.1469-0691.2009.02759.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45132297&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Shah, Rakhi B.
AU - Tawakkul, Mobin A.
AU - Sayeed, Vilayat A.
AU - Khan, Mansoor A.
T1 - Complexation between risperidone and amberlite resin by various methods of preparation and binding study.
JO - Drug Development & Industrial Pharmacy
JF - Drug Development & Industrial Pharmacy
Y1 - 2009/12//
VL - 35
IS - 12
M3 - Article
SP - 1409
EP - 1418
PB - Taylor & Francis Ltd
SN - 03639045
AB - Purpose: The purpose of this work was to investigate the effect of preparation methods and the drug-to-resin ratio on complex formation between risperidone and amberlite resin. Methods: The existence of such resin complex may provide taste-masking properties to the dosage forms. It is important to determine when and how the complex forms. Therefore, in this study, the complexes of risperidone and amberlite resin were prepared by granulation, solution, and freeze-drying methods at various drug-to-resin ratios. The physical mixtures of drug–resin were used to compare the results of complexes prepared by granulation, solution, and freeze drying. The complexes were evaluated by various methods of characterization including differential scanning calorimetry, X-ray diffraction, spectroscopy (near infrared, Fourier transform infrared, and Raman), drug release, and binding studies. Results: Complexation between risperidone and amberlite was investigated for various preparation methods. It was found that complexation occurred at lower amounts of amberlite resin (drug-to-resin ratios of 1:1 and 1:2) when solution form of drug was contacted with the resin as in the case of solution and freeze-drying techniques compared with granulation (drug-to-resin ratios of 1:4 and 1:6). Characterization studies such as differential scanning calorimetry, X-ray diffraction, spectroscopic techniques, and drug release studies differentiated complexes from the physical mixtures. Binding studies between them revealed that the binding was linear with solubility of the drug limiting the adsorption capacity. Conclusions: Results of the study highlighted the importance of the preparation methodologies to formulate complexes. When the drug and the resin were simply mixed physically, no complexation occurred. Thus, a careful evaluation of manufacturing procedure would indicate the nature and extent of complexation. [ABSTRACT FROM AUTHOR]
AB - Copyright of Drug Development & Industrial Pharmacy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DOSAGE of drugs
KW - X-ray diffractometer
KW - RAMAN spectroscopy
KW - RISPERIDONE
KW - ANTIPSYCHOTIC drugs
KW - Amberlite
KW - binding
KW - complexation
KW - freeze drying
KW - granulation
KW - risperidone
N1 - Accession Number: 45389967; Shah, Rakhi B. 1; Tawakkul, Mobin A. 1; Sayeed, Vilayat A. 2; Khan, Mansoor A. 1; Email Address: mansoor.khan@fda.hhs.gov; Affiliations: 1: Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA; 2: Office of Generic Drugs, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, USA; Issue Info: Dec2009, Vol. 35 Issue 12, p1409; Subject Term: DOSAGE of drugs; Subject Term: X-ray diffractometer; Subject Term: RAMAN spectroscopy; Subject Term: RISPERIDONE; Subject Term: ANTIPSYCHOTIC drugs; Author-Supplied Keyword: Amberlite; Author-Supplied Keyword: binding; Author-Supplied Keyword: complexation; Author-Supplied Keyword: freeze drying; Author-Supplied Keyword: granulation; Author-Supplied Keyword: risperidone; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 10p; Illustrations: 1 Chart, 8 Graphs; Document Type: Article
L3 - 10.3109/03639040902939247
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=45389967&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
AU - Ying Li
AU - Ehrhard, Ray
AU - Biswas, Pratim
AU - Kulkarni, Pramod
AU - Carns, Keith
AU - Patterson, Craig
AU - Krishnan, Radha
AU - Sinha, Rajib
T1 - Removal of Waterborne Particles by Electrofiltration: Pilot-Scale Testing.
JO - Environmental Engineering Science
JF - Environmental Engineering Science
Y1 - 2009/12//
VL - 26
IS - 12
M3 - Article
SP - 1795
EP - 1803
SN - 10928758
AB - Theoretical analysis using a trajectory approach indicated that in the presence of an external electric field, charged waterborne particles are subject to an additional migration velocity that increases their deposition on the surface of collectors (e.g., sand filter). Although researchers conducted bench-scale experiments to verify the effectiveness of electrofiltration, few studies have reported on the applications of electrofiltration in larger scale facilities. In this study, a prototype pilot-scale electrofiltration unit, consisting of an acrylic tank (0.3 × 0.3 × 1.2 m) with vertically placed stainless steel mesh electrodes embedded in a sand filter was tested at a local drinking water plant. Presedimentation basin water was used as the influent with a turbidity ranging from 12 to 37 NTU. At an approach velocity of 0.84 mm/s, an electrode voltage at 8 and 12 V increased the particle removal coefficient pC* [defined as −log(Cout/Cin)] to 1.79 and 1.86, respectively, compared to 1.48 when there was no electric field. Reducing the approach velocity from 0.84 to 0.42 mm/s increased pC* from 1.48 to 1.64, when the electrode velocity was 16 V. Repetitive experiments were conducted and the results were in agreement with those calculated by a theoretical trajectory analysis. The electrofiltration process was demonstrated to be more effective for removal of smaller particles (<4 μm), the size range of many waterborne bacteria. A voltage of 8–12 V was shown to be the most cost-effective range, considering both the energy cost and filtration performance. The findings from this pilot-scale study are important for full-scale applications of the electrofiltration technology. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Engineering Science is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - WATER -- Purification
KW - FILTERS & filtration
KW - ELECTRODES
KW - CHROME steel
KW - CONTAMINATION of drinking water
KW - collection efficiency
KW - drinking water
KW - electrofiltration
KW - pathogens
KW - trajectory analysis
KW - water treatment
KW - waterborne particles
N1 - Accession Number: 45572517; Ying Li 1 Ehrhard, Ray 1 Biswas, Pratim 1; Email Address: pratim.biswas@wustl.edu Kulkarni, Pramod 2 Carns, Keith 3 Patterson, Craig 4 Krishnan, Radha 5 Sinha, Rajib 5; Affiliation: 1: Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, Missouri 2: Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 3: Global Energy Partners, LLC, Oakhurst, California 4: Office of Research and Development, National Risk Management Research Laboratory, U.S. Environmental Protection Agency, Cincinnati, Ohio 5: Shaw Environmental and Infrastructure, Inc., Cincinnati, Ohio; Source Info: Dec2009, Vol. 26 Issue 12, p1795; Subject Term: WATER -- Purification; Subject Term: FILTERS & filtration; Subject Term: ELECTRODES; Subject Term: CHROME steel; Subject Term: CONTAMINATION of drinking water; Author-Supplied Keyword: collection efficiency; Author-Supplied Keyword: drinking water; Author-Supplied Keyword: electrofiltration; Author-Supplied Keyword: pathogens; Author-Supplied Keyword: trajectory analysis; Author-Supplied Keyword: water treatment; Author-Supplied Keyword: waterborne particles; NAICS/Industry Codes: 221310 Water Supply and Irrigation Systems; Number of Pages: 9p; Illustrations: 2 Diagrams, 4 Charts, 5 Graphs; Document Type: Article
L3 - 10.1089/ees.2009.0238
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45572517&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Jefferson, Wendy N.
AU - Doerge, Daniel
AU - Padilla-Banks, Elizabeth
AU - Woodling, Kellie A.
AU - Kissling, Grace E.
AU - Newbold, Retha
T1 - Oral Exposure to Genistin, the Glycosylated Form of Genistein, during Neonatal Life Adversely Affects the Female Reproductive System.
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
Y1 - 2009/12//
VL - 117
IS - 12
M3 - Article
SP - 1883
EP - 1889
PB - Superintendent of Documents
SN - 00916765
AB - Background: Developmental exposure to environmental estrogens is associated with adverse consequences later in life. Exposure to genistin (GIN), the glycosylated form of the phytoestrogen genistein (GEN) found in soy products, is of concern because approximately 20% of U.S. infants are fed soy formula. High circulating levels of GEN have been measured in the serum of these infants, indicating that GIN is readily absorbed, hydrolyzed, and circulated. Objectives: We investigated whether orally administered GIN is estrogenic in neonatal mice and whether it causes adverse effects on the developing female reproductive tract. Methods: Female CD-1 mice were treated on postnatal days 1-5 with oral GIN (6.25, 12.5, 25, or 37.5 mg/kg/day; GEN-equivalent doses), oral GEN (25, 37.5, or 75 mg/kg/day), or subcutaneous GEN (12.5, 20, or 25 mg/kg/day). Estrogenic activity was measured on day 5 by determining uterine wet weight gain and induction of the estrogen-responsive gene lactoferrin. Vaginal opening, estrous cyclicity, fertility, and morphologic alterations in the ovary/reproductive tract were examined. Results: Oral GIN elicited an estrogenic response in the neonatal uterus, whereas the response to oral GEN was much weaker. Oral GIN altered ovarian differentiation (i.e., multioocyte follicles), delayed vaginal opening, caused abnormal estrous cycles, decreased fertility, and delayed parturition. Conclusions: Our results support the idea that the dose of the physiologically active compound reaching the target tissue, rather than the administered dose or route, is most important in modeling chemical exposures. This is particularly true with young animals in which phase II metabolism capacity is underdeveloped relative to adults. [ABSTRACT FROM AUTHOR]
AB - Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FEMALE reproductive organs
KW - PHYTOESTROGENS
KW - MICE as laboratory animals
KW - LACTOFERRIN
KW - METABOLISM
KW - GLYCOSYLATED hemoglobin
KW - development
KW - diethylstilbestrol
KW - endocrine disruptors
KW - environmental estrogen
KW - isoflavone
KW - ovary
N1 - Accession Number: 47971970; Jefferson, Wendy N. 1,2; Email Address: jeffers1@niehs.nih.gov Doerge, Daniel 3 Padilla-Banks, Elizabeth 1,2 Woodling, Kellie A. 3 Kissling, Grace E. 4 Newbold, Retha 2,5; Affiliation: 1: Laboratory of Reproductive and Developmental Toxicology 2: Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA 3: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA; 4: Biostatistics Branch 5: National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; Source Info: Dec2009, Vol. 117 Issue 12, p1883; Subject Term: FEMALE reproductive organs; Subject Term: PHYTOESTROGENS; Subject Term: MICE as laboratory animals; Subject Term: LACTOFERRIN; Subject Term: METABOLISM; Subject Term: GLYCOSYLATED hemoglobin; Author-Supplied Keyword: development; Author-Supplied Keyword: diethylstilbestrol; Author-Supplied Keyword: endocrine disruptors; Author-Supplied Keyword: environmental estrogen; Author-Supplied Keyword: isoflavone; Author-Supplied Keyword: ovary; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1289/ehp.0900923
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47971970&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ackerman, L. K.
AU - Noonan, G. O.
AU - Begley, T. H.
T1 - Assessing direct analysis in real-time-mass spectrometry (DART-MS) for the rapid identification of additives in food packaging.
JO - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
JF - Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment
Y1 - 2009/12//
VL - 26
IS - 12
M3 - Article
SP - 1611
EP - 1618
PB - Taylor & Francis Ltd
SN - 19440049
AB - The ambient ionization technique direct analysis in real time (DART) was characterized and evaluated for the screening of food packaging for the presence of packaging additives using a benchtop mass spectrometer (MS). Approximate optimum conditions were determined for 13 common food-packaging additives, including plasticizers, anti-oxidants, colorants, grease-proofers, and ultraviolet light stabilizers. Method sensitivity and linearity were evaluated using solutions and characterized polymer samples. Additionally, the response of a model additive (di-ethyl-hexyl-phthalate) was examined across a range of sample positions, DART, and MS conditions (temperature, voltage and helium flow). Under optimal conditions, molecular ion (M+H+) was the major ion for most additives. Additive responses were highly sensitive to sample and DART source orientation, as well as to DART flow rates, temperatures, and MS inlet voltages, respectively. DART-MS response was neither consistently linear nor quantitative in this setting, and sensitivity varied by additive. All additives studied were rapidly identified in multiple food-packaging materials by DART-MS/MS, suggesting this technique can be used to screen food packaging rapidly. However, method sensitivity and quantitation requires further study and improvement. [ABSTRACT FROM AUTHOR]
AB - Copyright of Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Food -- Packaging
KW - Additives
KW - Ionization (Atomic physics)
KW - Mass spectrometers
KW - Voltage regulators
KW - food-contact materials
KW - in-house validation
KW - packaging additives
KW - paper
KW - plastics
KW - screening assays
N1 - Accession Number: 47522089; Ackerman, L. K. 1; Email Address: Luke.Ackerman@fda.hhs.gov; Noonan, G. O. 1; Begley, T. H. 1; Affiliations: 1: US Food and Drug Administration (USFDA), Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.; Issue Info: Dec2009, Vol. 26 Issue 12, p1611; Thesaurus Term: Food -- Packaging; Thesaurus Term: Additives; Subject Term: Ionization (Atomic physics); Subject Term: Mass spectrometers; Subject Term: Voltage regulators; Author-Supplied Keyword: food-contact materials; Author-Supplied Keyword: in-house validation; Author-Supplied Keyword: packaging additives; Author-Supplied Keyword: paper; Author-Supplied Keyword: plastics; Author-Supplied Keyword: screening assays; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 334516 Analytical Laboratory Instrument Manufacturing; NAICS/Industry Codes: 423610 Electrical Apparatus and Equipment, Wiring Supplies, and Related Equipment Merchant Wholesalers; NAICS/Industry Codes: 334410 Semiconductor and other electronic component manufacturing; Number of Pages: 8p; Illustrations: 1 Diagram, 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/02652030903232753
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=47522089&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Day, J.B.
AU - Nguyen, H.
AU - Sharma, S.K.
AU - Al-Khaldi, S.F.
AU - Hao, Y.-Y.D.
T1 - Effect of dehydrated storage on the survival of Francisella tularensis in infant formula
JO - Food Microbiology
JF - Food Microbiology
Y1 - 2009/12//
VL - 26
IS - 8
M3 - Article
SP - 932
EP - 935
SN - 07400020
AB - Abstract: Francisella tularensis is a Gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are few studies on the long-term survivability of this organism in food matrices. Infant formula has previously been implicated as a vehicle for the transmission of a variety of bacterial pathogens in infants. In this study, we investigated the survival of F. tularensis in dehydrated infant formula under various storage conditions. F. tularensis was stored for up to 12 weeks in dehydrated infant formula in an ambient air, dry or nitrogen atmosphere. Viable counts of fresh F. tularensis at 12 weeks in infant formula revealed a 4.15, 3.37 and 3.72-log decrease in ambient air, dry and nitrogen atmosphere, respectively. D-values were calculated (in weeks) as 3.99, 4.68 and 4.47 in air, dry and nitrogen atmosphere, respectively. [Copyright &y& Elsevier]
AB - Copyright of Food Microbiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FRANCISELLA tularensis
KW - INFANT formulas
KW - FOOD contamination
KW - FOOD -- Drying
KW - PATHOGENIC bacteria
KW - INFANT nutrition
KW - NITROGEN
KW - Dehydration
KW - Francisella tularensis
KW - Infant formula
KW - Survival
N1 - Accession Number: 44702138; Day, J.B. 1; Email Address: james.day@fda.hhs.gov Nguyen, H. 2 Sharma, S.K. 1 Al-Khaldi, S.F. 1 Hao, Y.-Y.D. 1; Affiliation: 1: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA 2: Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, MD 20740, USA; Source Info: Dec2009, Vol. 26 Issue 8, p932; Subject Term: FRANCISELLA tularensis; Subject Term: INFANT formulas; Subject Term: FOOD contamination; Subject Term: FOOD -- Drying; Subject Term: PATHOGENIC bacteria; Subject Term: INFANT nutrition; Subject Term: NITROGEN; Author-Supplied Keyword: Dehydration; Author-Supplied Keyword: Francisella tularensis; Author-Supplied Keyword: Infant formula; Author-Supplied Keyword: Survival; NAICS/Industry Codes: 311423 Dried and Dehydrated Food Manufacturing; NAICS/Industry Codes: 311514 Dry, Condensed, and Evaporated Dairy Product Manufacturing; NAICS/Industry Codes: 311515 Butter, cheese, and dry and condensed dairy product manufacturing; NAICS/Industry Codes: 325120 Industrial Gas Manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.fm.2009.06.005
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44702138&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mukamel, Dana B.
AU - Ladd, Heather
AU - Weimer, David L.
AU - Spector, William D.
AU - Zinn, Jacqueline S.
T1 - Is There Evidence of Cream Skimming Among Nursing Homes Following the Publication of the Nursing Home Compare Report Card?
JO - Gerontologist
JF - Gerontologist
Y1 - 2009/12//
VL - 49
IS - 6
M3 - Article
SP - 793
EP - 802
SN - 00169013
AB - Purpose: A national quality report card for nursing homes, Nursing Home Compare, has been published since 2002. It has been shown to have some, albeit limited, positive impact on quality of care. The objective of this study was to test empirically the hypothesis that nursing homes have responded to the publication of the report by adopting cream skimming admission policies. Design and Methods: The study included all non-Medicare newly admitted patients to all Medicare- and Medicaid-certified nursing homes nationally during the 2001–2005 period. Using the Minimum Data Set data, we calculated for each quarter several admission cohort characteristics: average number of activity of daily living limitations and percent of residents admitted with pain, with pressure ulcers, with urinary incontinence, with diabetes, and with memory limitations. We tested whether residents admitted in the postpublication period were less frail and sick compared with residents admitted in the prepublication period by estimating fixed facility effects longitudinal regression models. Analyses were stratified by nursing home ownership, occupancy, reported quality ranking, chain affiliation, and region. Results: Evidence for cream skimming was found with respect to pain and, to a lesser degree, with respect to memory limitation but not with respect to the 4 other admission cohort characteristics. Implications: Despite the theoretical expectation, empirical evidence suggests only a limited degree of cream skimming. Further studies are required to investigate this phenomenon with respect to other admission cohort characteristics and with respect to post-acute patients. [ABSTRACT FROM PUBLISHER]
AB - Copyright of Gerontologist is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - NURSING care facilities -- Ratings & rankings
KW - MEDICARE
KW - MEDICAID
KW - NURSING home patients
KW - DIABETES
KW - BEDSORES
KW - Cream skimming
KW - Nursing homes
KW - Quality
KW - Report cards
N1 - Accession Number: 47449776; Mukamel, Dana B. 1,2; Email Address: dmukamel@uci.edu Ladd, Heather Weimer, David L. 3 Spector, William D. 4 Zinn, Jacqueline S. 5; Affiliation: 1: Health Policy Research Institute, University of California, Irvine, 111 Academy, Suite 220, Irvine, CA 92697-5800 2: Health Policy Research Institute, University of California, Irvine 3: LaFollette School of Public Affairs, University of Wisconsin -- Madison 4: Agency for Healthcare Research and Quality, Rockville, Maryland 5: Fox School of Business and Management, Temple University, Philadelphia, Pennsylvania; Source Info: Dec2009, Vol. 49 Issue 6, p793; Subject Term: NURSING care facilities -- Ratings & rankings; Subject Term: MEDICARE; Subject Term: MEDICAID; Subject Term: NURSING home patients; Subject Term: DIABETES; Subject Term: BEDSORES; Author-Supplied Keyword: Cream skimming; Author-Supplied Keyword: Nursing homes; Author-Supplied Keyword: Quality; Author-Supplied Keyword: Report cards; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 10p; Illustrations: 2 Charts, 2 Graphs; Document Type: Article
L3 - 10.1093/geront/gnp062
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Steven
AU - Ezzati-Rice, Trena
AU - Zodet, Marc
T1 - The impact of survey design modifications on health insurance coverage estimates in a National Longitudinal Health Care Survey.
JO - Health Services & Outcomes Research Methodology
JF - Health Services & Outcomes Research Methodology
Y1 - 2009/12//
VL - 9
IS - 4
M3 - Article
SP - 197
EP - 218
SN - 13873741
AB - National health insurance coverage estimates for the overall population and specific population subgroups are critical to policymakers and others concerned with access to medical care and the cost and sources of payment for that care. The Medical Expenditure Panel Survey (MEPS) is one of the core health care surveys in the United States that serves as a primary source for these essential national health insurance coverage estimates. The survey is designed to provide annual national estimates of the health care use, medical expenditures, sources of payment and insurance coverage for the U.S. civilian non-institutionalized population. In 2007, the survey experienced two dominant survey design modifications: (1) a new sample design attributable to the sample redesign of the National Health Interview Survey, and (2) an upgrade to the CAPI platform for the survey instrument, moving from a DOS to a Windows based environment. This study examines the impact of these survey design modifications on the national estimates of insurance coverage. The overlapping panel design of the MEPS survey and its longitudinal features are particularly well suited to assess the impact of survey redesign modifications on estimates. Since two independent nationally representative samples are pooled to produce calendar year estimates, one has the capacity to compare estimates based on the “original survey design” in contrast to those derived from the “survey redesign.” This paper examines the correlates of nonresponse incorporated in the estimation techniques and adjustment methods employed in the survey, and the measures utilized for post-stratification overall and by panel. Particular attention is given to assessing the level of convergence in coverage estimates based on the alternative designs as well as the alignment of model based analyses that discern which factors are associated with health insurance classifications. The paper concludes with a discussion of strategies under consideration that may yield additional improvements in the accuracy for these critical policy relevant survey estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services & Outcomes Research Methodology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE statistics
KW - SURVEYS
KW - EVALUATION
KW - HEALTH insurance -- United States
KW - INSURANCE
KW - CLINICAL medicine
KW - COMPUTER software
KW - EXPERIMENTAL design
KW - RESEARCH -- Methodology
KW - MEDICAL care costs
KW - MEDICALLY uninsured persons
KW - SAMPLE size (Statistics)
KW - STATISTICS
KW - UNITED States
KW - Health insurance coverage
KW - MEPS
KW - Survey redesign
N1 - Accession Number: 52858658; Cohen, Steven 1; Email Address: Steven.Cohen@ahrq.hhs.gov Ezzati-Rice, Trena 1 Zodet, Marc 1; Affiliation: 1: Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road, John M. Eisenberg Building Rockville 20850 USA; Source Info: Dec2009, Vol. 9 Issue 4, p197; Subject Term: INSURANCE statistics; Subject Term: SURVEYS; Subject Term: EVALUATION; Subject Term: HEALTH insurance -- United States; Subject Term: INSURANCE; Subject Term: CLINICAL medicine; Subject Term: COMPUTER software; Subject Term: EXPERIMENTAL design; Subject Term: RESEARCH -- Methodology; Subject Term: MEDICAL care costs; Subject Term: MEDICALLY uninsured persons; Subject Term: SAMPLE size (Statistics); Subject Term: STATISTICS; Subject Term: UNITED States; Author-Supplied Keyword: Health insurance coverage; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: Survey redesign; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; Number of Pages: 22p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1007/s10742-010-0058-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=52858658&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Cohen, Steven
AU - Ezzati-Rice, Trena
AU - Zodet, Marc
T1 - The impact of survey design modifications on health insurance coverage estimates in a National Longitudinal Health Care Survey.
JO - Health Services & Outcomes Research Methodology
JF - Health Services & Outcomes Research Methodology
Y1 - 2009/12//
VL - 9
IS - 4
M3 - Article
SP - 197
EP - 218
SN - 13873741
AB - National health insurance coverage estimates for the overall population and specific population subgroups are critical to policymakers and others concerned with access to medical care and the cost and sources of payment for that care. The Medical Expenditure Panel Survey (MEPS) is one of the core health care surveys in the United States that serves as a primary source for these essential national health insurance coverage estimates. The survey is designed to provide annual national estimates of the health care use, medical expenditures, sources of payment and insurance coverage for the U.S. civilian non-institutionalized population. In 2007, the survey experienced two dominant survey design modifications: (1) a new sample design attributable to the sample redesign of the National Health Interview Survey, and (2) an upgrade to the CAPI platform for the survey instrument, moving from a DOS to a Windows based environment. This study examines the impact of these survey design modifications on the national estimates of insurance coverage. The overlapping panel design of the MEPS survey and its longitudinal features are particularly well suited to assess the impact of survey redesign modifications on estimates. Since two independent nationally representative samples are pooled to produce calendar year estimates, one has the capacity to compare estimates based on the “original survey design” in contrast to those derived from the “survey redesign.” This paper examines the correlates of nonresponse incorporated in the estimation techniques and adjustment methods employed in the survey, and the measures utilized for post-stratification overall and by panel. Particular attention is given to assessing the level of convergence in coverage estimates based on the alternative designs as well as the alignment of model based analyses that discern which factors are associated with health insurance classifications. The paper concludes with a discussion of strategies under consideration that may yield additional improvements in the accuracy for these critical policy relevant survey estimates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Health Services & Outcomes Research Methodology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - INSURANCE statistics
KW - HEALTH insurance
KW - INSURANCE
KW - COMPUTER software
KW - RESEARCH
KW - MEDICALLY uninsured persons
KW - STATISTICS
KW - SURVEYS -- Evaluation
KW - CLINICAL medicine
KW - EXPERIMENTAL design
KW - METHODOLOGY
KW - MEDICAL care costs
KW - SAMPLE size (Statistics)
KW - EVALUATION
KW - UNITED States
KW - Health insurance coverage
KW - MEPS
KW - Survey redesign
N1 - Accession Number: 52858658; Cohen, Steven 1; Email Address: Steven.Cohen@ahrq.hhs.gov; Ezzati-Rice, Trena 1; Zodet, Marc 1; Affiliations: 1: Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road, John M. Eisenberg Building Rockville 20850 USA; Issue Info: Dec2009, Vol. 9 Issue 4, p197; Thesaurus Term: INSURANCE statistics; Thesaurus Term: HEALTH insurance; Thesaurus Term: INSURANCE; Thesaurus Term: COMPUTER software; Thesaurus Term: RESEARCH; Thesaurus Term: MEDICALLY uninsured persons; Thesaurus Term: STATISTICS; Subject Term: SURVEYS -- Evaluation; Subject Term: CLINICAL medicine; Subject Term: EXPERIMENTAL design; Subject Term: METHODOLOGY; Subject Term: MEDICAL care costs; Subject Term: SAMPLE size (Statistics); Subject Term: EVALUATION; Subject: UNITED States; Author-Supplied Keyword: Health insurance coverage; Author-Supplied Keyword: MEPS; Author-Supplied Keyword: Survey redesign; NAICS/Industry Codes: 511211 Software publishers (except video game publishers); NAICS/Industry Codes: 443144 Computer and software stores; NAICS/Industry Codes: 423430 Computer and Computer Peripheral Equipment and Software Merchant Wholesalers; NAICS/Industry Codes: 417310 Computer, computer peripheral and pre-packaged software merchant wholesalers; Number of Pages: 22p; Illustrations: 1 Diagram, 5 Charts; Document Type: Article
L3 - 10.1007/s10742-010-0058-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=buh&AN=52858658&site=ehost-live&scope=site
DP - EBSCOhost
DB - buh
ER -
TY - JOUR
ID - 105088127
T1 - The impact of survey design modifications on health insurance coverage estimates in a National Longitudinal Health Care Survey.
AU - Cohen S
AU - Ezzati-Rice T
AU - Zodet M
Y1 - 2009/12//
N1 - Accession Number: 105088127. Language: English. Entry Date: 20101020. Revision Date: 20150711. Publication Type: Journal Article; research; tables/charts. Journal Subset: Biomedical; Continental Europe; Europe; Health Services Administration. NLM UID: 9815809.
KW - Instrument Construction
KW - Insurance, Health -- Statistics and Numerical Data -- United States
KW - Surveys -- Evaluation
KW - Health Care Costs -- Statistics and Numerical Data
KW - Health Care Costs -- Evaluation
KW - Medical Care -- Utilization -- United States
KW - Insurance Coverage -- Statistics and Numerical Data -- United States
KW - Medically Uninsured -- Statistics and Numerical Data
KW - United States
KW - Software
KW - Sample Size
KW - Research Methodology
SP - 197
EP - 218
JO - Health Services & Outcomes Research Methodology
JF - Health Services & Outcomes Research Methodology
JA - HEALTH SERV OUTCOMES RES METHODOL
VL - 9
IS - 4
CY - ,
PB - Springer Science & Business Media B.V.
SN - 1387-3741
AD - Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road, John M. Eisenberg Building Rockville 20850 USA
DO - 10.1007/s10742-010-0058-y
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105088127&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Badal, Andreu
AU - Kyprianou, lacovos
AU - Banh, Diem Phuc
AU - Badano, Aldo
AU - Sempau, Josep
T1 - penMesh — Monte Carlo Radiation Transport Simulation in a Triangle Mesh Geometry.
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
Y1 - 2009/12//
VL - 28
IS - 12
M3 - Article
SP - 1894
EP - 1901
SN - 02780062
AB - We have developed a general-purpose Monte Carlo simulation code, called penMesh, that combines the accuracy of the radiation transport physics subroutines from PENELOPE and the flexibility of a geometry based on triangle meshes. While the geometric models implemented in most general-purpose codes-such as PENELOPE's quadric geometry-impose some limitations in the shape of the objects that can be simulated, triangle meshes can be used to describe any free-form (arbitrary) object. Triangle meshes are extensively used in computer-aided design and computer graphics. We took advantage of the sophisticated tools already developed in these fields, such as an octree structure and an efficient ray-triangle intersection algorithm, to significantly accelerate the triangle mesh ray-tracing. A detailed description of the new simulation code and its ray-tracing algorithm is provided in this paper. Furthermore, we show how it can be readily used in medical imaging applications thanks to the detailed anatomical phantoms already available. In particular, we present a whole body radiography simulation using a triangulated version of the anthropomorphic NCAT phantom. An example simulation of scatter fraction measurements using a standardized abdomen and lumbar spine phantom, and a benchmark of the triangle mesh and quadric geometries in the ray-tracing of a mathematical breast model, are also presented to show some of the capabilities of penMesh. [ABSTRACT FROM AUTHOR]
AB - Copyright of IEEE Transactions on Medical Imaging is the property of IEEE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - RADIOTHERAPY
KW - MONTE Carlo method
KW - COMPUTER-aided design
KW - GEOMETRY
KW - ALGORITHMS
KW - COMPUTER simulation
KW - LUMBAR vertebrae
KW - COMPUTER graphics
KW - Computer-aided design
KW - Monte Carlo
KW - NCAT
KW - PENELOPE
KW - penMesh
KW - triangle mesh
N1 - Accession Number: 46786894; Badal, Andreu 1,2; Email Address: andreu.badalsoler@fda.hhs.gov Kyprianou, lacovos 2; Email Address: iacovos.kyprianou@fda.hhs.gov Banh, Diem Phuc 2 Badano, Aldo 2 Sempau, Josep 1,3; Affiliation: 1: Institut de Tecniques Energètiques, Universitat Politëcnica de Catalunya, 08028 Barcelona, Spain 2: NIBIB/CDRH Laboratory for the Assessment of Medical Imaging Systems, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA 3: Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028 Barcelona, Spain; Source Info: Dec2009, Vol. 28 Issue 12, p1894; Subject Term: RADIOTHERAPY; Subject Term: MONTE Carlo method; Subject Term: COMPUTER-aided design; Subject Term: GEOMETRY; Subject Term: ALGORITHMS; Subject Term: COMPUTER simulation; Subject Term: LUMBAR vertebrae; Subject Term: COMPUTER graphics; Author-Supplied Keyword: Computer-aided design; Author-Supplied Keyword: Monte Carlo; Author-Supplied Keyword: NCAT; Author-Supplied Keyword: PENELOPE; Author-Supplied Keyword: penMesh; Author-Supplied Keyword: triangle mesh; NAICS/Industry Codes: 541512 Computer Systems Design Services; Number of Pages: 7p; Document Type: Article
L3 - 10.1109/TMI.2009.2021615
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=46786894&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Togo, Fumiharu
AU - Takahashi, Masaya
T1 - Heart Rate Variability in Occupational Health --A Systematic Review.
JO - Industrial Health
JF - Industrial Health
Y1 - 2009/12//
VL - 47
IS - 6
M3 - Article
SP - 589
EP - 602
SN - 00198366
AB - The article focuses on the meta-analysis of relation between work-related factors and heart rate variability (HRV) in workers. The research was conducted to check the number of dependent variables which included time and frequency-domain indexes of HRV. The findings focused on physical and chemical work environments, psychosocial workload, and working time which indicated that parasympathetic nervous system activity should be focused to protect cardiovascular health of workers.
KW - Occupational diseases
KW - Heart beat
KW - Meta-analysis
KW - Work-related injuries
KW - Variables (Logic)
KW - Work sampling
KW - Psychosocial factors
KW - Autonomic nervous system
KW - Cardiovascular disease
KW - Fatigue
KW - HRV
KW - Physical and chemical work environment
KW - Psychosocial workload
KW - Shift work
N1 - Accession Number: 77412081; Togo, Fumiharu 1; Email Address: togo@h.jniosh.go.jp; Takahashi, Masaya 1; Affiliations: 1: National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Issue Info: 2009, Vol. 47 Issue 6, p589; Thesaurus Term: Occupational diseases; Subject Term: Heart beat; Subject Term: Meta-analysis; Subject Term: Work-related injuries; Subject Term: Variables (Logic); Subject Term: Work sampling; Subject Term: Psychosocial factors; Author-Supplied Keyword: Autonomic nervous system; Author-Supplied Keyword: Cardiovascular disease; Author-Supplied Keyword: Fatigue; Author-Supplied Keyword: HRV; Author-Supplied Keyword: Physical and chemical work environment; Author-Supplied Keyword: Psychosocial workload; Author-Supplied Keyword: Shift work; Number of Pages: 14p; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=77412081&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Schwartzkopff, Franziska
AU - Grimm, Tobias A.
AU - Lankford, Carla S. R.
AU - Fields, Karen
AU - Jiun Wang
AU - Brandt, Ernst
AU - Clouse, Kathleen A.
T1 - Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replication.
JO - Innate Immunity
JF - Innate Immunity
Y1 - 2009/12//
VL - 15
IS - 6
M3 - Article
SP - 368
EP - 379
SN - 17534259
AB - Platelet factor 4 (CXCL4), a member of the CXC chemokine subfamily released in high amounts by activated platelets, has been identified as a monocyte survival factor that induces monocyte differentiation into macrophages. Although CXCL4 has been shown to have biological effects unique to chemokines, nothing is known about the role of CXCL4-derived human macrophages or CXCL4 in human immunodeficiency virus (HIV) disease. In this study, CXCL4-derived macrophages are compared with macrophage-colony stimulating factor (M-CSF)-derived macrophages for their ability to support HIV-1 replication. We show that CXCL4-derived macrophages can be infected with macrophage-tropic HIV-1 that uses either CC-chemokine receptor 5 (CCR5) or CXC-chemokine receptor 4 (CXCR4) as a co-receptor for viral entry. We also find that M-CSF and the chemokines, monocyte chemoattractant protein 1 (MCP-1; CCL2) and macrophage-inflammatory-protein-1-alpha (MIP-1α; CCL3) are produced upon R5- and X4-tropic HIV-1 replication in both M-CSF- and CXCL4-derived human macrophages. In addition, CXCL4 added to M-CSF-derived macrophages after virus adsorption and maintained throughout the infection enhances HIV-1 replication. We thus propose a novel role for CXCL4 in HIV disease. [ABSTRACT FROM AUTHOR]
AB - Copyright of Innate Immunity is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MACROPHAGES
KW - CONNECTIVE tissue cells
KW - CHEMOKINES
KW - MONOCYTES
KW - PHAGOCYTES
KW - HIV (Viruses)
KW - CXCL4
KW - cytokines
KW - HIV-1
KW - M-CSF
KW - macrophages
N1 - Accession Number: 47107772; Schwartzkopff, Franziska 1 Grimm, Tobias A. 2 Lankford, Carla S. R. 2 Fields, Karen 2 Jiun Wang 2 Brandt, Ernst 1 Clouse, Kathleen A. 2; Email Address: kathleen.clouse@fda.hhs.gov; Affiliation: 1: Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany 2: Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland, USA; Source Info: Dec2009, Vol. 15 Issue 6, p368; Subject Term: MACROPHAGES; Subject Term: CONNECTIVE tissue cells; Subject Term: CHEMOKINES; Subject Term: MONOCYTES; Subject Term: PHAGOCYTES; Subject Term: HIV (Viruses); Author-Supplied Keyword: CXCL4; Author-Supplied Keyword: cytokines; Author-Supplied Keyword: HIV-1; Author-Supplied Keyword: M-CSF; Author-Supplied Keyword: macrophages; Number of Pages: 12p; Illustrations: 5 Graphs; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47107772&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - MARANAZ-ANDRÉS, JESUS
AU - AIBAR-REMÓN, C.
AU - VITALLER-BURILLO, J.
AU - REQUENA-PUCHE, J.
AU - TEROL-GARCÍA, E.
AU - KELLEY, E.
AU - DE CASTRO, M.T . GEA-VELAZQUEZ
T1 - Impact and preventability of adverse events in Spanish public hospitals: results of the Spanish National Study of Adverse Events (ENEAS).
JO - International Journal for Quality in Health Care
JF - International Journal for Quality in Health Care
Y1 - 2009/12//
VL - 21
IS - 6
M3 - Article
SP - 408
EP - 414
SN - 13534505
AB - Objective: To determine the impact and preventability of adverse events (AEs) associated with health care in Spanish hospitals. [ABSTRACT FROM PUBLISHER]
AB - Copyright of International Journal for Quality in Health Care is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PUBLIC hospitals
KW - ADVERSE health care events
KW - MEDICAL care
KW - MEDICAL errors
KW - SPAIN
KW - adverse events
KW - clinical safety
KW - medical errors
KW - patient safety
KW - quality of care
N1 - Accession Number: 47431922; MARANAZ-ANDRÉS, JESUS 1,2; Email Address: aranaz_jes@gva.es AIBAR-REMÓN, C. 3,4 VITALLER-BURILLO, J. 2 REQUENA-PUCHE, J. 1,2 TEROL-GARCÍA, E. 5 KELLEY, E. 6 DE CASTRO, M.T . GEA-VELAZQUEZ 1,2; Affiliation: 1: Department of Preventive Medicine, Teaching Hospital of Sant Joan d'Alacant, Miguel Hernández University of Elche, Spain 2: Department of Public Health, History Science and Gynaechology, Miguel Hernández University of Elche, Spain 3: Department of Preventive Medicine, Teaching Hospital Lozano Blesa, University of Zaragoza, Spain 4: Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, Spain 5: Quality Office of the National Health Service, Ministry of Health and Consumption, Spain 6: Agency for Healthcare Research and Quality, Rockville, MD, USA; Source Info: Dec2009, Vol. 21 Issue 6, p408; Subject Term: PUBLIC hospitals; Subject Term: ADVERSE health care events; Subject Term: MEDICAL care; Subject Term: MEDICAL errors; Subject Term: SPAIN; Author-Supplied Keyword: adverse events; Author-Supplied Keyword: clinical safety; Author-Supplied Keyword: medical errors; Author-Supplied Keyword: patient safety; Author-Supplied Keyword: quality of care; NAICS/Industry Codes: 622110 General Medical and Surgical Hospitals; Number of Pages: 7p; Illustrations: 4 Charts, 1 Graph; Document Type: Article
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47431922&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Karacan, C. Özgen
T1 - Reconciling longwall gob gas reservoirs and venthole production performances using multiple rate drawdown well test analysis
JO - International Journal of Coal Geology
JF - International Journal of Coal Geology
Y1 - 2009/12//
VL - 80
IS - 3/4
M3 - Article
SP - 181
EP - 195
SN - 01665162
AB - Abstract: Longwall mining is an underground mining method during which a mechanical shearer progressively mines a large block of coal, called a panel, in an extensive area. During this operation the roof of the coal seam is supported only temporarily with hydraulic supports that protect the workers and the equipment on the coal face. As the coal is extracted, the supports automatically advance and the roof strata cave behind the supports. Caving results in fracturing and relaxation of the overlying strata, which is called “gob.” Due its highly fractured nature, gob contains many flow paths for gas migration. Thus, if the overlying strata contain gassy sandstones or sandstone channels, gas shales or thinner coal seams which are not suitable for mining, then the mining-induced changes can cause unexpected or uncontrolled gas migration into the underground workplace. Vertical gob gas ventholes (GGV) are drilled into each longwall panel to capture the methane within the overlying fractured strata before it enters the work environment. Thus, it is important, first to understand the properties of the gas reservoir created by mining disturbances and, second, to optimize the well parameters and placement accordingly. In this paper, the production rate-pressure behaviors of six GGVs drilled over three adjacent panels were analyzed by using conventional multi-rate drawdown analysis techniques. The analyses were performed for infinite acting and pseudo-steady state flow models, which may be applicable during panel mining (DM) and after mining (AM) production periods of GGVs. These phases were analyzed separately since the reservoir properties, due to dynamic subsidence, boundary conditions and gas capacity of the gob reservoir may change between these two stages. The results suggest that conventional well test analysis techniques can be applicable to highly complex gob reservoirs and GGVs to determine parameters such as skin, permeability, radius of investigation, flow efficiency and damage ratio. The insights obtained from well test analyses can be used for a better understanding of the gob and for designing more effective gob gas venthole systems. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Coal Geology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - LONGWALL mining
KW - GAS reservoirs
KW - COAL mine waste
KW - PERFORMANCE evaluation
KW - METHANE
KW - RESERVOIR drawdown
KW - NATURAL gas -- Migration
KW - Drawdown test
KW - Gob gas ventholes
KW - Longwall mining
KW - Methane control
KW - Multi-rate test
KW - Production performance
KW - Well testing
N1 - Accession Number: 45215418; Karacan, C. Özgen 1; Email Address: cok6@cdc.gov; Affiliation: 1: National Institute for Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory, Pittsburgh 15236, PA, USA; Source Info: Dec2009, Vol. 80 Issue 3/4, p181; Subject Term: LONGWALL mining; Subject Term: GAS reservoirs; Subject Term: COAL mine waste; Subject Term: PERFORMANCE evaluation; Subject Term: METHANE; Subject Term: RESERVOIR drawdown; Subject Term: NATURAL gas -- Migration; Author-Supplied Keyword: Drawdown test; Author-Supplied Keyword: Gob gas ventholes; Author-Supplied Keyword: Longwall mining; Author-Supplied Keyword: Methane control; Author-Supplied Keyword: Multi-rate test; Author-Supplied Keyword: Production performance; Author-Supplied Keyword: Well testing; NAICS/Industry Codes: 211113 Conventional oil and gas extraction; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.coal.2009.09.006
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45215418&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Mora, Azucena
AU - Blanco, Miguel
AU - Yamamoto, Denise
AU - Dahbi, Ghizlane
AU - Blanco, Jesus E.
AU - López, Cecilia
AU - Alonso, María P.
AU - Vieira, Mônica A. M.
AU - Hernandes, Rodrigo T.
AU - Abe, Cecilia M.
AU - Piazza, Roxane M. F.
AU - Lacher, David W.
AU - Elias, Waldir P.
AU - Gomes, Tania A. T.
AU - Blanco, Jorge
T1 - HeLa-cell adherence patterns and actin aggregation of enteropathogenic Escherichia colt (EPEC) and Shiga-toxin-producing E. coli (STEC) strains carrying different eae and tir alleles.
JO - International Microbiology
JF - International Microbiology
Y1 - 2009/12//
VL - 12
IS - 4
M3 - Article
SP - 243
EP - 251
SN - 11396709
AB - A collection of 69 eae-positive strains expressing 29 different intimin types and eight tir alleles was characterized with respect to their adherence patterns to HeLa cells, ability to promote actin accumulation in vitro, the presence of bfpA alleles in positive strains, and bundle-forming pilus (BFP) expression. All of the nine typical enteropathogenic Escherichia coli (tEPEC) studied harbored the enteropathogenic E. coli adherence factor (EAF) plasmid, as shown by PCR and/or EAF probe results. In addition, they were positive for bfpA, as shown by PCR, and BFP expression, as confirmed by immunofluorescence (IFL) and/or immunoblotting (IBL) assays. Localized adherence (LA) was exclusively displayed by those nine tEPEC, while localized-adherence-like (LAL) was the most frequent pattern among atypical EPEC (aEPEC) and Shiga-toxin-producing E. coli (STEC). All LA and LAL strains were able to cause attaching and effacing (AE) lesions, as established by means of the FAS test. There was a significant association between the presence of tir allele α1 and bfpA-positive strains, and consequently, with the LA pattern. However, intimin type or bfpA was not associated with the adherence pattern displayed in HeLa cells. Among the eight bfpA alleles detected, a new type (β10; accession number FN391178) was identified in a strain of serotype O157:H45, and a truncated variant (β3.2-t; accession number FN 391181) in four strains belonging to different pathotypes. [ABSTRACT FROM AUTHOR]
AB - Copyright of International Microbiology is the property of Spanish Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ESCHERICHIA coli
KW - VEROCYTOTOXINS
KW - CELL adhesion
KW - HELA cells
KW - BACTERIAL adhesion
KW - enteropathogenic E. coli
KW - HeLa-cell adherence
KW - intimin
KW - Shiga-toxin-producing E. coli
N1 - Accession Number: 48377836; Mora, Azucena 1 Blanco, Miguel 1 Yamamoto, Denise 2 Dahbi, Ghizlane 1 Blanco, Jesus E. 1 López, Cecilia 1 Alonso, María P. 3 Vieira, Mônica A. M. 2 Hernandes, Rodrigo T. 2 Abe, Cecilia M. 4 Piazza, Roxane M. F. 4 Lacher, David W. 5 Elias, Waldir P. 4 Gomes, Tania A. T. 2 Blanco, Jorge 1; Email Address: jorge.blanco@usc.es; Affiliation: 1: Department of Microbiology and Parasitology, Faculty of Veterinary Science, University of Santiago de Compostela, Lugo, Spain 2: Department of Microbiology, Immunology and Parasitology, Sao Paulo School of Medicine, Federal University of Sao Paulo, Brazil 3: Unit of Microbiology, Calde Xeral Hospital, Lugo, Spain 4: Laboratory of Bacteriology, Butantan Institute, Sao Paulo, Brazil 5: Division of Molecular Biology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA; Source Info: Dec2009, Vol. 12 Issue 4, p243; Subject Term: ESCHERICHIA coli; Subject Term: VEROCYTOTOXINS; Subject Term: CELL adhesion; Subject Term: HELA cells; Subject Term: BACTERIAL adhesion; Author-Supplied Keyword: enteropathogenic E. coli; Author-Supplied Keyword: HeLa-cell adherence; Author-Supplied Keyword: intimin; Author-Supplied Keyword: Shiga-toxin-producing E. coli; Number of Pages: 9p; Illustrations: 4 Charts; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - SCHERR, DANIEL
AU - SHARMA, KAVITA
AU - DALAL, DARSHAN
AU - SPRAGG, DAVID
AU - CHILUKURI, KARUNA
AU - CHENG, ALAN
AU - DONG, JUN
AU - HENRIKSON, CHARLES A.
AU - NAZARIAN, SAMAN
AU - BERGER, RONALD D.
AU - CALKINS, HUGH
AU - MARINE, JOSEPH E.
T1 - Incidence and Predictors of Periprocedural Cerebrovascular Accident in Patients Undergoing Catheter Ablation of Atrial Fibrillation.
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
Y1 - 2009/12//
VL - 20
IS - 12
M3 - Article
SP - 1357
EP - 1363
PB - Wiley-Blackwell
SN - 10453873
AB - Background: Cerebrovascular accident (CVA) is a serious complication of catheter ablation of atrial fibrillation (AF). The incidence and clinical predictors of periprocedural CVA in patients undergoing AF ablation are not fully understood. Methods: This study included 721 cases (age 57 ± 11 years; 23% female; 345 persistent AF) in 579 consecutive patients referred for AF ablation. Periprocedural CVA was defined as onset of a new neurologic deficit that occurred anytime between the start of the procedure and 30 days after the AF ablation, and was confirmed by a neurologist. Cranial imaging with CT and/or MRI was performed in each case. Patients were anticoagulated with warfarin for at least 4 weeks pre- and immediately postprocedure and were bridged with enoxaparin. Transesophageal echocardiography was performed within 24 hours prior to ablation in all cases. Results: Periprocedural CVA occurred in 10 of 721 cases (1.4%). The risk of periprocedural CVA did not vary significantly during the course of the study. Among these 10 patients (age 62 ± 11 years; 1 female; 5 persistent AF), 6 manifested neurological deficits within 24 hours, 3 after 24–48 hours, and 1 patient had a CVA 6 days following AF ablation despite a therapeutic INR level. All CVAs were ischemic. Five patients had residual deficits after 30 days. Four of 43 patients (9.3%) with a prior history of CVA had periprocedural CVA. Periprocedural CVA occurred in 0.3%, 1.0%, and 4.7% of patients with CHADS2 scores of 0, 1, and ≥ 2 (P < 0.001). In 2 separate multivariate analyses, a CHADS2 score ≥ 2 (OR 7.1, P = 0.02) and history of CVA (OR 9.5, P < 0.01) remained independent predictors of periprocedural CVA. Conclusions: Despite periprocedural anticoagulation and transesophageal echocardiography, we found a 1.4% incidence of periprocedural CVA in AF ablation patients. A CHADS2 score ≥ 2 and a history of CVA are independent predictors of CVA after AF ablation. The CVA risk is low in patients with CHADS2 score of 0. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Cardiovascular Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CEREBROVASCULAR disease
KW - CATHETER ablation
KW - ATRIAL fibrillation -- Risk factors
KW - WARFARIN
KW - NEUROLOGIC examination
KW - TRANSESOPHAGEAL echocardiography
KW - MULTIVARIATE analysis
KW - ablation
KW - atrial fibrillation
KW - cerebrovascular accident
KW - complication
KW - embolism
KW - warfarin
N1 - Accession Number: 45393730; SCHERR, DANIEL 1,2 SHARMA, KAVITA 1 DALAL, DARSHAN 1 SPRAGG, DAVID 1 CHILUKURI, KARUNA 1 CHENG, ALAN 1 DONG, JUN 3 HENRIKSON, CHARLES A. 1 NAZARIAN, SAMAN 1 BERGER, RONALD D. 1 CALKINS, HUGH 1 MARINE, JOSEPH E. 1; Email Address: jmarine2@jhmi.edu; Affiliation: 1: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 2: Division of Cardiology, Department of Medicine, Medical University of Graz, Austria 3: Division of Cardiovascular Devices, Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA; Source Info: Dec2009, Vol. 20 Issue 12, p1357; Subject Term: CEREBROVASCULAR disease; Subject Term: CATHETER ablation; Subject Term: ATRIAL fibrillation -- Risk factors; Subject Term: WARFARIN; Subject Term: NEUROLOGIC examination; Subject Term: TRANSESOPHAGEAL echocardiography; Subject Term: MULTIVARIATE analysis; Author-Supplied Keyword: ablation; Author-Supplied Keyword: atrial fibrillation; Author-Supplied Keyword: cerebrovascular accident; Author-Supplied Keyword: complication; Author-Supplied Keyword: embolism; Author-Supplied Keyword: warfarin; Number of Pages: 7p; Illustrations: 5 Charts, 1 Graph; Document Type: Article
L3 - 10.1111/j.1540-8167.2009.01540.x
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kang, T. S.
AU - Jin, S. K.
AU - Lee, J. E.
AU - Woo, S. W.
AU - Roh, J.
T1 - Comparison of genetic polymorphisms of the NAT2 gene between Korean and four other ethnic groups.
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
Y1 - 2009/12//
VL - 34
IS - 6
M3 - Article
SP - 709
EP - 718
PB - Wiley-Blackwell
SN - 02694727
AB - Background and objective: N-acetyltransferase 2 (NAT2) is responsible for the acetylation of numerous drugs and in the transformation of aromatic and heterocyclinc amines into carcinogenic intermediates. Polymorphism of NAT2 may contribute to interindividual variability in such acetylation. The aim of this study was to determine the allele frequencies of polymorphisms of the NAT2 gene, analyse linkage disequilibrium (LD) block and haplotypes in Koreans and compare them with those of other ethnic groups. Methods: We analysed genetic polymorphisms in all functional promoter and exons of the NAT2 gene by direct sequencing of genomic DNA from 192 healthy Korean subjects. The LD and haplotype blocks of these subjects were constructed from genotype data using an expectation–maximization algorithm. We compared these allele frequencies, LD block and haplotype structure with those of other ethnic groups registered on the International HapMap database. Results and discussion: We identified 33 polymorphisms including six novel single nucleotide polymorphisms, −10778T>C, −10777A>G, −10351A>G, −10199C>T and −10104G>T in promoter and 578C>T in exon2 (T193M) in the Korean subjects tested. All allele frequencies reported in the Koreans were similar to those of Asians except for one allele (rs4345600, −9306A>G), whereas African and European groups had different frequencies in exon2. The haplotype structure and LD block among the five groups also revealed significant differences. Conclusion: Ethnic differences in the NAT2 genotype frequencies may be one of the important factors explaining variability in cancer incidence and drug toxicity. Our observations could be useful in assessing the susceptibility of different populations to cancer and contribute to better predictions of the pharmacokinetics and pharmacodynamics of drugs that are metabolized by NAT2, in different populations. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Clinical Pharmacy & Therapeutics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACETYLATION
KW - GENETIC polymorphisms
KW - ETHNIC groups
KW - AMINES
KW - GENES
KW - International HapMap
KW - NAT2
KW - pharmacogenetics
KW - polymorphisms
N1 - Accession Number: 45007007; Kang, T. S. 1 Jin, S. K. 1 Lee, J. E. 2 Woo, S. W. 1 Roh, J. 3; Email Address: rohjaesook@hanyang.ac.kr; Affiliation: 1: Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea. 2: DNA Link Inc., Mapo-gu, Seoul, South Korea. 3: Department of Obstetrics & Gynecology, Hanyang University Medical Center, Seoul, South Korea.; Source Info: Dec2009, Vol. 34 Issue 6, p709; Subject Term: ACETYLATION; Subject Term: GENETIC polymorphisms; Subject Term: ETHNIC groups; Subject Term: AMINES; Subject Term: GENES; Author-Supplied Keyword: International HapMap; Author-Supplied Keyword: NAT2; Author-Supplied Keyword: pharmacogenetics; Author-Supplied Keyword: polymorphisms; Number of Pages: 10p; Illustrations: 3 Diagrams, 3 Charts; Document Type: Article
L3 - 10.1111/j.1365-2710.2009.01065.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45007007&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105239813
T1 - Comparison of genetic polymorphisms of the NAT2 gene between Korean and four other ethnic groups.
AU - Kang TS
AU - Jin SK
AU - Lee JE
AU - Woo SW
AU - Roh J
Y1 - 2009/12//
N1 - Accession Number: 105239813. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; pictorial; research; tables/charts. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. Grant Information: Korea Food and Drug Administration. NLM UID: 8704308.
KW - Acetyltransferases
KW - Genes
KW - Polymorphism, Genetic
KW - Alleles
KW - Chi Square Test
KW - Confidence Intervals
KW - Data Analysis Software
KW - Ethnic Groups
KW - Funding Source
KW - Genotype
KW - Human
KW - Koreans
KW - Polymerase Chain Reaction
KW - Sequence Analysis
SP - 709
EP - 718
JO - Journal of Clinical Pharmacy & Therapeutics
JF - Journal of Clinical Pharmacy & Therapeutics
JA - J CLIN PHARM THER
VL - 34
IS - 6
CY - Malden, Massachusetts
PB - Wiley-Blackwell
AB - Background and objective: N-acetyltransferase 2 (NAT2) is responsible for the acetylation of numerous drugs and in the transformation of aromatic and heterocyclinc amines into carcinogenic intermediates. Polymorphism of NAT2 may contribute to interindividual variability in such acetylation. The aim of this study was to determine the allele frequencies of polymorphisms of the NAT2 gene, analyse linkage disequilibrium (LD) block and haplotypes in Koreans and compare them with those of other ethnic groups. Methods: We analysed genetic polymorphisms in all functional promoter and exons of the NAT2 gene by direct sequencing of genomic DNA from 192 healthy Korean subjects. The LD and haplotype blocks of these subjects were constructed from genotype data using an expectation-maximization algorithm. We compared these allele frequencies, LD block and haplotype structure with those of other ethnic groups registered on the International HapMap database. Results and discussion: We identified 33 polymorphisms including six novel single nucleotide polymorphisms, -10778T>C, -10777A>G, -10351A>G, -10199C>T and -10104G>T in promoter and 578C>T in exon2 (T193M) in the Korean subjects tested. All allele frequencies reported in the Koreans were similar to those of Asians except for one allele (rs4345600, -9306A>G), whereas African and European groups had different frequencies in exon2. The haplotype structure and LD block among the five groups also revealed significant differences. Conclusion: Ethnic differences in the NAT2 genotype frequencies may be one of the important factors explaining variability in cancer incidence and drug toxicity. Our observations could be useful in assessing the susceptibility of different populations to cancer and contribute to better predictions of the pharmacokinetics and pharmacodynamics of drugs that are metabolized by NAT2, in different populations.
SN - 0269-4727
AD - Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea
U2 - PMID: 20175805.
DO - 10.1111/j.1365-2710.2009.01065.x
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Dollan, Marc C.
AU - Jordan, Roberta A.
AU - Schulze, Terry L.
AU - Schulze, Christopher J.
AU - Manning, Mark Cornell
AU - Ruffolo, Daniel
AU - Schmidt, Jason P.
AU - Piesman, Joseph
AU - Karchesy, Joseph J.
T1 - Ability of Two Natural Products, Nootkatone and Carvacrol, to Suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey.
JO - Journal of Economic Entomology
JF - Journal of Economic Entomology
Y1 - 2009/12//
VL - 102
IS - 6
M3 - Article
SP - 2316
EP - 2324
SN - 00220493
AB - We evaluated the ability of the natural, plant-derived acaricides nootkatone and carvacrol to suppress Ixodes scapularis Say and Amblyomma amevicanum (L.) (Acari: Ixodidae). Aqueous formulations of 1 and 5% nootkatone applied by backpack sprayer to the forest litter layer completely suppressed I. scapularLs nymphs through 2 d. Thereafter, the level of reduction gradually declined to ⩽50% at 28 d postapplication. Against A. americanum nymphs, 1% nootkatone was less effective, but at a 5% concentration, the level of control was similar or greater to that observed with I. scapularis through 21 d postapplication. Initial applications of 0.05% carvacrol were ineffective, but a 5% carvacrol formulation completely suppressed nymphs of both species through 2 d and resulted in significant reduction in I. scapularis and A. americanum nymphs through 28 and 14 d postapplication, respectively. Backpack sprayer applications of 5% nootkatone to the shrub and litter layers resulted in 100% control of I. scapularis adults through 6 d, but the level of reduction declined to 71.5% at 28 d postapplication. By contrast, high-pressure applications of 2% nootkatone to the litter layer resulted in 96.2-100% suppression of both I. scapularis and A. americanum nymphs through 42 d, whereas much lower control was obtained from the same formulation applied by backpack sprayer. Backpack sprayer application of a 3.1% nootkatone nanoemulsion resulted in 97.5-98.9 and 99.3-100% reduction in I. scapularis and A. americanum nymphs, respectively, at 1 d postapplication. Between 7 d and 35 d postapplication, the level of control varied between 57.1% and 92.5% for I. scapulavis and between 78.5 and 97.1% for A. anwricanum nymphs. The ability of natural products to quickly suppress and maintain significant control of populations of these medically important ticks at relatively low concentrations may represent a future alternative to the use of conventional synthetic acaricides. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Economic Entomology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Acaricides
KW - Amblyomma
KW - Spraying & dusting in agriculture
KW - Carvacrol
KW - Ixodes scapularis
KW - Lyme disease
KW - New Jersey
KW - Amblyonsma americanum
KW - carvacrol
KW - Ixodes scaputaris
KW - nootkatone
KW - tick control
N1 - Accession Number: 47248080; Dollan, Marc C. 1,2; Email Address: mcd4@cdc.gov; Jordan, Roberta A. 2; Schulze, Terry L. 2,3; Schulze, Christopher J. 2,3; Manning, Mark Cornell 4; Ruffolo, Daniel 4; Schmidt, Jason P. 1; Piesman, Joseph 1; Karchesy, Joseph J. 5; Affiliations: 1: Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 3150 Rampart Rd., Fort Collins, CO 80521, USA; 2: Freehold Area Health Department, 1 Municipal Plaza, Freehold, NJ 07728, USA; 3: Terry L. Schuize Ph.D., Inc., 9 Evergreen Court, Perrineville, NJ 08535, USA; 4: Legacy BioDesign LLC, 4630 Sorrel Lane, Johnstown, CO 80534- 6404, USA; 5: Department of Wood Science and Engineering, Oregon State University, Corvallis, OR 97331, USA; Issue Info: Dec2009, Vol. 102 Issue 6, p2316; Thesaurus Term: Acaricides; Thesaurus Term: Amblyomma; Thesaurus Term: Spraying & dusting in agriculture; Subject Term: Carvacrol; Subject Term: Ixodes scapularis; Subject Term: Lyme disease; Subject: New Jersey; Author-Supplied Keyword: Amblyonsma americanum; Author-Supplied Keyword: carvacrol; Author-Supplied Keyword: Ixodes scaputaris; Author-Supplied Keyword: nootkatone; Author-Supplied Keyword: tick control; NAICS/Industry Codes: 418390 Agricultural chemical and other farm supplies merchant wholesalers; NAICS/Industry Codes: 115110 Support activities for crop production; NAICS/Industry Codes: 115112 Soil Preparation, Planting, and Cultivating; Number of Pages: 9p; Document Type: Article
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Huizhong Chen
AU - Haiyan Xu
AU - Heinze, Thomas M.
AU - Cerniglia, Carl E.
T1 - Decolorization of water and oil-soluble azo dyes by Lactobacillus acidophilus and Lactobacillus fermentum.
JO - Journal of Industrial Microbiology & Biotechnology
JF - Journal of Industrial Microbiology & Biotechnology
Y1 - 2009/12//
VL - 36
IS - 12
M3 - Article
SP - 1459
EP - 1466
PB - Springer Science & Business Media B.V.
SN - 13675435
AB - The capability of Lactobacillus acidophilus and Lactobacillus fermentum to degrade azo dyes was investigated. The bacteria were incubated under anaerobic conditions in the presence of 6 µg/ml Methyl Red, Ponceau BS, Orange G, Amaranth, Orange II, and Direct Blue 15; 5 µg/ml Sudan I and II; or 1.5 µg/ml Sudan III and IV in deMann–Rogosa–Sharpe broth at 37°C for 36 h, and reduction of the dyes was monitored. Both bacteria were capable of degrading all of the water-soluble azo dyes to some extent. They were also able to completely reduce the oil-soluble diazo dyes Sudan III and IV but were unable to reduce the oil-soluble monoazo dyes Sudan I and II to any significant degree in the concentrations studied. Growth of the bacteria was not significantly affected by the presence of the Sudan azo dyes. Metabolites of the bacterial degradation of Sudan III and IV were isolated and identified by liquid chromatography electrospray ionization tandem mass spectrometry analyses and compared with authentic standards. Aniline and o-toluidine (2-methylaniline), both potentially carcinogenic aromatic amines, were metabolites of Sudan III and IV, respectively. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Industrial Microbiology & Biotechnology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - AZO dyes
KW - WATER -- Color
KW - LACTOBACILLUS acidophilus
KW - FERMENTATION
KW - LIQUID chromatography
KW - Aromatic amines
KW - Azo dyes
KW - Biodegradation
KW - Lactobacillus species
KW - Sudan dyes
N1 - Accession Number: 45110090; Huizhong Chen 1; Email Address: huizhong.chen@fda.hhs.gov Haiyan Xu 1 Heinze, Thomas M. 2 Cerniglia, Carl E. 1; Affiliation: 1: Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., JeVerson, AR 72079-9502, USA. 2: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., JeVerson, AR 72079-9502, USA.; Source Info: Dec2009, Vol. 36 Issue 12, p1459; Subject Term: AZO dyes; Subject Term: WATER -- Color; Subject Term: LACTOBACILLUS acidophilus; Subject Term: FERMENTATION; Subject Term: LIQUID chromatography; Author-Supplied Keyword: Aromatic amines; Author-Supplied Keyword: Azo dyes; Author-Supplied Keyword: Biodegradation; Author-Supplied Keyword: Lactobacillus species; Author-Supplied Keyword: Sudan dyes; NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; Number of Pages: 8p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1007/s10295-009-0633-9
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lessa, Fernanda C.
AU - Gould, Philip L.
AU - Pascoe, Neil
AU - Erdman, Dean D.
AU - Xiaoyan Lu
AU - Bunning, Michel L.
AU - Marconi, Vincent C.
AU - Lott, Lisa
AU - Widdowson, Marc-Alain
AU - Anderson, Larry J.
AU - Srinivasan, Arjun
T1 - Health Care Transmission of a Newly Emergent Adenovirus Serotype in Health Care Personnel at a Military Hospital in Texas, 2007.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/12//12/1/2009
VL - 200
IS - 11
M3 - Article
SP - 1759
EP - 1765
SN - 00221899
AB - Background. Adenoviruses can cause outbreaks of febrile respiratory illness in military trainees, but until 2007, adenovirus serotype 14 (Ad14) was never associated with such outbreaks. From April through June 2007, 15 trainees at one base were hospitalized for pneumonia due to Ad14. Subsequent reports of febrile respiratory illness among health care personnel suggested nosocomial transmission. Methods. Health care personnel participants completed a questionnaire and provided blood and nasal wash specimens for Ad14 diagnostic testing. We defined a confirmed case of Ad14 infection as one with titers ⩾1:80 or nasal wash specimens positive for Ad14 by polymerase chain reaction, whereas a possible case was defined by titers of 1:20 or 1:40. We also collected environmental samples. Results. Among 218 tested health care personnel, 35 (16%) had titers ⩾1:20; of these, 7 had possible cases and 28 had confirmed cases of infection. Confirmed case patients were more likely to report febrile respiratory illness (57% vs 11%; P < .001) and to have had direct contact with patients with Ad14 infection (82% vs 62%; P=.04). Of the 23 confirmed case patients with direct contact with Ad14-infected patients, 52% reported that patients were not in contact and droplet precautions at the time of exposure. Ad14 was recovered from several hospital surfaces. Conclusion. Our findings of possible nosocomial transmission of Ad14 highlight the need to reinforce infection control guidelines. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ADENOVIRUSES
KW - RESPIRATORY infections
KW - MEDICAL personnel
KW - MILITARY hospitals
KW - SEROTYPES
KW - ENVIRONMENTAL sampling
KW - POLYMERASE chain reaction
KW - QUESTIONNAIRES
KW - NOSOCOMIAL infections
KW - TEXAS
N1 - Accession Number: 45566202; Lessa, Fernanda C. 1,2; Email Address: flessa@cdc.gov Gould, Philip L. 2,3 Pascoe, Neil 4 Erdman, Dean D. 3 Xiaoyan Lu 3 Bunning, Michel L. 5 Marconi, Vincent C. 6 Lott, Lisa 7 Widdowson, Marc-Alain 3 Anderson, Larry J. 3 Srinivasan, Arjun 1; Affiliation: 1: Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases 2: Epidemic Intelligence Service, Office of Workforce and Career Development 3: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 4: Texas Department of State Health Services, Austin 5: Air Force Medical Operations Agency, United States Air Force, Kelly Air Force Base 6: Wilford Hall US Air Force Medical Center 7: Epidemic Outbreak Surveillance, Advanced Diagnostics Laboratory, Modernization Directorate, Office of the Surgeon General, Lackland Air Force Base, Texas; Source Info: 12/1/2009, Vol. 200 Issue 11, p1759; Subject Term: ADENOVIRUSES; Subject Term: RESPIRATORY infections; Subject Term: MEDICAL personnel; Subject Term: MILITARY hospitals; Subject Term: SEROTYPES; Subject Term: ENVIRONMENTAL sampling; Subject Term: POLYMERASE chain reaction; Subject Term: QUESTIONNAIRES; Subject Term: NOSOCOMIAL infections; Subject Term: TEXAS; NAICS/Industry Codes: 622111 General (except paediatric) hospitals; Number of Pages: 7p; Illustrations: 3 Charts, 1 Graph; Document Type: Article
L3 - 10.1086/647987
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Takahashi, Yukio
T1 - Vibratory Sensation Induced by Low-Frequency Noise: A Pilot Study on the Threshold Level.
JO - Journal of Low Frequency Noise, Vibration & Active Control
JF - Journal of Low Frequency Noise, Vibration & Active Control
Y1 - 2009/12//
VL - 28
IS - 4
M3 - Article
SP - 245
EP - 253
SN - 02630923
AB - The induction of vibratory sensation is a characteristic of low-frequency noise. In this pilot study we measured the threshold levels to induce a vibratory sensation in normal-hearing subjects exposed to pure tones within a narrow frequency range (20-50 Hz). The threshold levels necessary to induce a vibratory sensation were found to be 5-17 dB(SPL) higher than the hearing threshold levels; these vibratory sensation levels were lower than the sensation threshold levels in deaf subjects previously measured by another research group. This difference suggested the possibility that the function of the hearing organs is related to the perception of vibration in normal-hearing persons exposed to low-frequency noise. Our study showed that the head was the part of the body in which the vibratory sensation was most often experienced, which supported the idea that the hearing organs may contribute to the normal-hearing person's perception of vibratory sensation. Another interesting finding of our study was a dip appearing in the threshold level for the vibratory sensation at 40 Hz. This was broadly in agreement with another group's result that sensitivity to vibration was greatest at frequencies between 40 and 80 Hz. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Low Frequency Noise, Vibration & Active Control is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEARING levels
KW - VIBRATION (Mechanics)
KW - HEARING -- Research
KW - SENSES & sensation
KW - PERCEPTION
KW - Low-frequency noise
KW - Sensitivity to vibratory sensation
KW - Threshold levels
KW - Vibratory sensation
N1 - Accession Number: 48654782; Takahashi, Yukio 1; Email Address: takahay@h.jniosh.go.jp; Affiliation: 1: Work Environment Research Group, National Institute of Occupational Safety and Health, Japan. 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Source Info: Dec2009, Vol. 28 Issue 4, p245; Subject Term: HEARING levels; Subject Term: VIBRATION (Mechanics); Subject Term: HEARING -- Research; Subject Term: SENSES & sensation; Subject Term: PERCEPTION; Author-Supplied Keyword: Low-frequency noise; Author-Supplied Keyword: Sensitivity to vibratory sensation; Author-Supplied Keyword: Threshold levels; Author-Supplied Keyword: Vibratory sensation; Number of Pages: 9p; Illustrations: 2 Diagrams, 1 Chart, 3 Graphs; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105289045
T1 - Development of a database for government-funded health/functional food research.
AU - Kim JY
AU - Park J
AU - Kwon O
Y1 - 2009/12//
N1 - Accession Number: 105289045. Language: English. Entry Date: 20100312. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Alternative/Complementary Therapies; Biomedical; Peer Reviewed; USA. Special Interest: Nutrition. NLM UID: 9812512.
KW - Functional Food -- Korea
KW - Government Agencies -- Korea
KW - Reference Databases, Health -- Korea
KW - Research Support -- Korea
KW - Research, Alternative Therapies -- Korea
KW - Research, Dietetics -- Korea
KW - Alternative Therapies
KW - Cardiovascular System
KW - Immune System
KW - Korea
KW - Medicine, Herbal
KW - Oxidative Stress
KW - Plants, Edible
KW - Plants, Medicinal
KW - Research Methodology
KW - Study Design
SP - 1185
EP - 1189
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
JA - J MEDICINAL FOOD
VL - 12
IS - 6
CY - New Rochelle, New York
PB - Mary Ann Liebert, Inc.
AB - The Korean Health/Functional Food Act of 2002 has led to the promotion of research on health/functional foods (HFFs). In order to track government-funded studies on HFFs, a free accessible database (National Research & Development on Functional Food, NaReaD(ff)) has been established by the Korea Food and Drug Administration. About 200 project reports funded by government agencies from 1993 through 2007 were retrieved, using existing government-wide online databases created by the Korea Institute Science and Technology, Evaluation and Planning and the Korea Institute of Science and Technology Information. In 2008, the database was released with information regarding individual projects and technological achievements for individual ingredients with a vision for HFF development. Overall, government-funded HFF research has primarily involved botanicals including herbs and food plants. The immune system, oxidant stress alleviation, and the cardiovascular system are the three leading health systems being investigated. With regard to the types of studies performed, the majority were in vitro studies and animal studies with limited numbers of human intervention studies. Government funds have been fragmented for many different ingredients, and this represents a major gap in HFF development. This database is most valuable for evaluating trends in government-funded HFF research. It is also useful to identify research overlaps and gaps and to help research scientists within academia and industry identify potential sources of government funding.
SN - 1096-620X
AD - Division of Nutrition and Functional Food Standards, Korea Food and Drug Administration, Seoul, Republic of Korea.
U2 - PMID: 20041770.
DO - 10.1089/jmf.2008.1036
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105289045&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Ekechukwu, Amy
T1 - Proceedings of the Third International Symposium on Beryllium Particulates and Their Detection November 17-19, 2008, Albuquerque, New Mexico.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/12//
VL - 6
IS - 12
M3 - Article
SP - 89
EP - 91
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents information on the third International Symposium on Beryllium Particulates and Their Detection that was held during November 17-19, 2008 in Albuquerque, New Mexico. The symposium was participated by scientists, medical researchers, industrial hygienists and other public health professionals to share current information about detecting beryllium particles. They discussed the health risks posed by exposure to beryllium.
KW - Beryllium
KW - Conferences & conventions
KW - Public health personnel
KW - Albuquerque (N.M.)
KW - New Mexico
N1 - Accession Number: 45020639; Ashley, Kevin 1; Ekechukwu, Amy 2; Affiliations: 1: National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: Savannah River National Laboratory, Aiken, South Carolina.; Issue Info: Dec2009, Vol. 6 Issue 12, p89; Thesaurus Term: Beryllium; Subject Term: Conferences & conventions; Subject Term: Public health personnel; Subject: Albuquerque (N.M.); Subject: New Mexico; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 561920 Convention and Trade Show Organizers; Number of Pages: 3p; Document Type: Article
L3 - 10.1080/15459620903158607
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45020639&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Braybrooke, Geoffrey
AU - Jahn, Steven D.
AU - Brisson, Michael J.
AU - White, Kenneth T.
T1 - Analytical Performance Criteria.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/12//
VL - 6
IS - 12
M3 - Article
SP - 97
EP - 100
PB - Taylor & Francis Ltd
SN - 15459624
AB - The article presents information on available standardized methods that are used to surface samples for subsequent metals measurement, notably beryllium. Some representative surfaces and substrates of interest that are applicable to beryllium sampling include hard/smooth /nonporous surfaces, soft/rough/porous substrates, bulk materials. A study has found alcohol to be most effective for removing beryllium dust from oily surfaces, while dry wipes were least effective for this purpose.
KW - Beryllium
KW - Alkaline earth metals
KW - Substrates (Materials science)
KW - Surfaces (Technology)
KW - Sampling (Process)
N1 - Accession Number: 45020637; Ashley, Kevin 1; Braybrooke, Geoffrey 2; Jahn, Steven D. 3; Brisson, Michael J. 3; White, Kenneth T. 4; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland.; 3: Savannah River Nuclear Solutions, Aiken, South Carolina.; 4: Consultive Services, Virginia Beach, Virginia.; Issue Info: Dec2009, Vol. 6 Issue 12, p97; Thesaurus Term: Beryllium; Thesaurus Term: Alkaline earth metals; Subject Term: Substrates (Materials science); Subject Term: Surfaces (Technology); Subject Term: Sampling (Process); NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 4p; Illustrations: 1 Chart; Document Type: Article
L3 - 10.1080/15459620903022597
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45020637&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Goldcamp, Michael J.
AU - Goldcamp, Diane M.
AU - Ashley, Kevin
AU - Fernback, Joseph E.
AU - Agrawal, Anoop
AU - Millson, Mark
AU - Marlow, David
AU - Harrison, Kenneth
T1 - Extraction of Beryllium from Refractory Beryllium Oxide with Dilute Ammonium Bifluoride and Determination by Fluorescence: A Multiparameter Performance Evaluation.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/12//
VL - 6
IS - 12
M3 - Article
SP - 735
EP - 744
PB - Taylor & Francis Ltd
SN - 15459624
AB - Beryllium exposure can cause a number of deleterious health effects, including beryllium sensitization and the potentially fatal chronic beryllium disease. Efficient methods for monitoring beryllium contamination in workplaces are valuable to help prevent dangerous exposures to this element. In this work, performance data on the extraction of beryllium from various size fractions of high-fired beryllium oxide (BeO) particles (from < 32 μ m up to 212 μ m) using dilute aqueous ammonium bifluoride (ABF) solution were obtained under various conditions. Beryllium concentrations were determined by fluorescence using a hydroxybenzoquinoline fluorophore. The effects of ABF concentration and volume, extraction temperature, sample tube types, and presence of filter or wipe media were examined. Three percent ABF extracts beryllium nearly twice as quickly as 1% ABF; extraction solution volume has minimal influence. Elevated temperatures increase the rate of extraction dramatically compared with room temperature extraction. Sample tubes with constricted tips yield poor extraction rates owing to the inability of the extraction medium to access the undissolved particles. The relative rates of extraction of Be from BeO of varying particle sizes were examined. Beryllium from BeO particles in fractions ranging from less than 32 μ m up to 212 μ m were subjected to various extraction schemes. The smallest BeO particles are extracted more quickly than the largest particles, although at 90°C even the largest BeO particles reach nearly quantitative extraction within 4 hr in 3% ABF. Extraction from mixed cellulosic-ester filters, cellulosic surface-sampling filters, wetted cellulosic dust wipes, and cotton gloves yielded 90% or greater recoveries. Scanning electron microscopy of BeO particles, including partially dissolved particles, shows that dissolution in dilute ABF occurs not just on the exterior surface but also via accessing particles' interiors due to porosity of the BeO material. Comparison of dissolution kinetics data shows that as particle diameter approximately doubles, extraction time is increased by a factor of about 1.5, which is consistent with the influence of porosity on dissolution. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Permeability
KW - Beryllium oxide
KW - Fluorescence
KW - Electron microscopy
KW - beryllium oxide
KW - dissolution
KW - extraction
KW - fluorescence analysis
KW - surface samples
N1 - Accession Number: 45020648; Goldcamp, Michael J. 1; Email Address: michaelgoldcamp@wilmington.edu; Goldcamp, Diane M. 1,2; Ashley, Kevin 3; Fernback, Joseph E. 3; Agrawal, Anoop 4; Millson, Mark 3; Marlow, David 3; Harrison, Kenneth 5; Affiliations: 1: Wilmington College, Wilmington, Ohio.; 2: Notre Dame Academy, Park Hills, Kentucky.; 3: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 4: Berylliant, Inc., Tucson, Arizona.; 5: Brush Ceramics, Tucson, Arizona.; Issue Info: Dec2009, Vol. 6 Issue 12, p735; Thesaurus Term: Beryllium; Thesaurus Term: Permeability; Subject Term: Beryllium oxide; Subject Term: Fluorescence; Subject Term: Electron microscopy; Author-Supplied Keyword: beryllium oxide; Author-Supplied Keyword: dissolution; Author-Supplied Keyword: extraction; Author-Supplied Keyword: fluorescence analysis; Author-Supplied Keyword: surface samples; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; Number of Pages: 10p; Illustrations: 5 Black and White Photographs, 7 Charts, 1 Graph; Document Type: Article
L3 - 10.1080/15459620903012044
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45020648&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ashley, Kevin
AU - Brisson, Michael J.
AU - Howe, Alan M.
AU - Bartley, David L.
T1 - Interlaboratory Evaluation of a Standardized Inductively Coupled Plasma Mass Spectrometry Method for the Determination of Trace Beryllium in Air Filter Samples.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/12//
VL - 6
IS - 12
M3 - Article
SP - 745
EP - 750
PB - Taylor & Francis Ltd
SN - 15459624
AB - A collaborative interlaboratory evaluation of a newly standardized inductively coupled plasma mass spectrometry (ICP-MS) method for determining trace beryllium in workplace air samples was carried out toward fulfillment of method validation requirements for ASTM International voluntary consensus standard test methods. The interlaboratory study (ILS) was performed in accordance with an applicable ASTM International standard practice, ASTM E691, which describes statistical procedures for investigating interlaboratory precision. Uncertainty was also estimated in accordance with ASTM D7440, which applies the International Organization for Standardization Guide to the Expression of Uncertainty in Measurement to air quality measurements. Performance evaluation materials (PEMs) used consisted of 37 mm diameter mixed cellulose ester filters that were spiked with beryllium at levels of 0.025 (low loading), 0.5 (medium loading), and 10 (high loading) μ g Be/filter; these spiked filters were prepared by a contract laboratory. Participating laboratories were recruited from a pool of over 50 invitees; ultimately, 20 laboratories from Europe, North America, and Asia submitted ILS results. Triplicates of each PEM (blanks plus the three different loading levels) were conveyed to each volunteer laboratory, along with a copy of the draft standard test method that each participant was asked to follow; spiking levels were unknown to the participants. The laboratories were requested to prepare the PEMs by one of three sample preparation procedures (hotplate or microwave digestion or hotblock extraction) that were described in the draft standard. Participants were then asked to analyze aliquots of the prepared samples by ICP-MS and to report their data in units of μ g Be/filter sample. Interlaboratory precision estimates from participating laboratories, computed in accordance with ASTM E691, were 0.165, 0.108, and 0.151 (relative standard deviation) for the PEMs spiked at 0.025, 0.5, and 10 μ g Be/filter, respectively. Overall recoveries were 93.2%, 102%, and 80.6% for the low, medium, and high beryllium loadings, respectively. Expanded uncertainty estimates for interlaboratory analysis of low, medium, and high beryllium loadings, calculated in accordance with ASTM D7440, were 18.8%, 19.8%, and 24.4%, respectively. These figures of merit support promulgation of the analytical procedure as an ASTM International standard test method, ASTM D7439. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Mass spectrometry
KW - Dust control
KW - Air pollution
KW - United States
KW - beryllium
KW - consensus standards
KW - inductively coupled plasma-mass spectrometry
KW - interlaboratory analysis
KW - workplace air
N1 - Accession Number: 45020647; Ashley, Kevin 1; Email Address: KAshley@cdc.gov; Brisson, Michael J. 2; Howe, Alan M. 3; Bartley, David L. 4; Affiliations: 1: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio.; 2: Savannah River Nuclear Solutions, Aiken, South Carolina.; 3: Health and Safety Laboratory, Buxton, Derbyshire, England.; 4: BartlEquations, Cincinnati, Ohio.; Issue Info: Dec2009, Vol. 6 Issue 12, p745; Thesaurus Term: Beryllium; Thesaurus Term: Mass spectrometry; Thesaurus Term: Dust control; Thesaurus Term: Air pollution; Subject: United States; Author-Supplied Keyword: beryllium; Author-Supplied Keyword: consensus standards; Author-Supplied Keyword: inductively coupled plasma-mass spectrometry; Author-Supplied Keyword: interlaboratory analysis; Author-Supplied Keyword: workplace air; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; Number of Pages: 6p; Illustrations: 5 Charts; Document Type: Article
L3 - 10.1080/15459620903022605
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Ekechukwu, Amy
AU - Hendricks, Warren
AU - White, Kenneth T.
AU - Liabastre, Albert
AU - Archuleta, Melecita
AU - Hoover, Mark D.
T1 - Validation of Analytical Methods and Instrumentation for Beryllium Measurement: Review and Summary of Available Guides, Procedures, and Protocols.
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
Y1 - 2009/12//
VL - 6
IS - 12
M3 - Article
SP - 766
EP - 774
PB - Taylor & Francis Ltd
SN - 15459624
AB - This document provides a listing of available sources that can be used to validate analytical methods and/or instrumentation for beryllium determination. A literature review was conducted of available standard methods and publications used for method validation and/or quality control. An annotated listing of the articles, papers, and books reviewed is given in the Appendix. Available validation documents and guides are listed therein; each has a brief description of application and use. In the referenced sources, there are varying approaches to validation and varying descriptions of the validation process at different stages in method development. This discussion focuses on validation and verification of fully developed methods and instrumentation that have been offered for use or approval by other laboratories or official consensus bodies such as ASTM International, the International Standards Organization, the International Electrotechnical Commission, and the Association of Official Analytical Chemists. This review was conducted as part of a collaborative effort to investigate and improve the state of validation for measuring beryllium in the workplace and the environment. Documents and publications from the United States and Europe are included. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Occupational & Environmental Hygiene is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Beryllium
KW - Measurement
KW - Sampling (Statistics)
KW - Quality function deployment
KW - United States
KW - analytical method development
KW - beryllium
KW - protocol
KW - validation
N1 - Accession Number: 45020643; Ekechukwu, Amy 1; Email Address: amy.ekechukwu@srnl.doe.gov; Hendricks, Warren 2; White, Kenneth T. 3; Liabastre, Albert 4; Archuleta, Melecita 5; Hoover, Mark D. 6; Affiliations: 1: Savannah River National Laboratory, Aiken, South Carolina.; 2: Occupational Safety and Health Administration, Sandy, Utah.; 3: Consultive Services, Virginia Beach, Virginia.; 4: U.S. Army Center for Health Promotion and Preventive Medicine, Ft. McPherson, Georgia.; 5: Sandia National Laboratories, Albuquerque, New Mexico.; 6: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia.; Issue Info: Dec2009, Vol. 6 Issue 12, p766; Thesaurus Term: Beryllium; Subject Term: Measurement; Subject Term: Sampling (Statistics); Subject Term: Quality function deployment; Subject: United States; Author-Supplied Keyword: analytical method development; Author-Supplied Keyword: beryllium; Author-Supplied Keyword: protocol; Author-Supplied Keyword: validation; NAICS/Industry Codes: 212299 All Other Metal Ore Mining; NAICS/Industry Codes: 541910 Marketing Research and Public Opinion Polling; Number of Pages: 9p; Document Type: Article
L3 - 10.1080/15459620903260536
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45020643&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
ID - 105239625
T1 - Interlaboratory evaluation of a standardized inductively coupled plasma mass spectrometry method for the determination of trace beryllium in air filter samples.
AU - Ashley K
AU - Brisson MJ
AU - Howe AM
AU - Bartley DL
Y1 - 2009/12//
N1 - Accession Number: 105239625. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Note: For CE see pages D101-3. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Grant Information: Funding support for the ILS was provided in part by ASTM International. NLM UID: 101189458.
KW - Air Pollutants
KW - Air Pollution -- Evaluation
KW - Beryllium
KW - Occupational Exposure -- Evaluation
KW - Mass Spectrometry
KW - Clinical Laboratories
KW - Education, Continuing (Credit)
KW - Environmental Monitoring
KW - Funding Source
KW - Interrater Reliability
KW - Validity
SP - 745
EP - 750
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
AB - A collaborative interlaboratory evaluation of a newly standardized inductively coupled plasma mass spectrometry (ICP-MS) method for determining trace beryllium in workplace air samples was carried out toward fulfillment of method validation requirements for ASTM International voluntary consensus standard test methods. The interlaboratory study (ILS) was performed in accordance with an applicable ASTM International standard practice, ASTM E691, which describes statistical procedures for investigating interlaboratory precision. Uncertainty was also estimated in accordance with ASTM D7440, which applies the International Organization for Standardization Guide to the Expression of Uncertainty in Measurement to air quality measurements. Performance evaluation materials (PEMs) used consisted of 37 mm diameter mixed cellulose ester filters that were spiked with beryllium at levels of 0.025 (low loading), 0.5 (medium loading), and 10 (high loading) microg Be/filter; these spiked filters were prepared by a contract laboratory. Participating laboratories were recruited from a pool of over 50 invitees; ultimately, 20 laboratories from Europe, North America, and Asia submitted ILS results. Triplicates of each PEM (blanks plus the three different loading levels) were conveyed to each volunteer laboratory, along with a copy of the draft standard test method that each participant was asked to follow; spiking levels were unknown to the participants. The laboratories were requested to prepare the PEMs by one of three sample preparation procedures (hotplate or microwave digestion or hotblock extraction) that were described in the draft standard. Participants were then asked to analyze aliquots of the prepared samples by ICP-MS and to report their data in units of mu g Be/filter sample. Interlaboratory precision estimates from participating laboratories, computed in accordance with ASTM E691, were 0.165, 0.108, and 0.151 (relative standard deviation) for the PEMs spiked at 0.025, 0.5, and 10 microg Be/filter, respectively. Overall recoveries were 93.2%, 102%, and 80.6% for the low, medium, and high beryllium loadings, respectively. Expanded uncertainty estimates for interlaboratory analysis of low, medium, and high beryllium loadings, calculated in accordance with ASTM D7440, were 18.8%, 19.8%, and 24.4%, respectively. These figures of merit support promulgation of the analytical procedure as an ASTM International standard test method, ASTM D7439.
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. KAshley@cdc.gov
U2 - PMID: 19894175.
DO - 10.1080/15459620903022605
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105239625&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105270060
T1 - Proceedings of the Third International Symposium on Beryllium Particulates and Their Detection November 17-19, 2008, Albuquerque, New Mexico.
AU - Ashley K
AU - Ekechukwu A
Y1 - 2009/12//
N1 - Accession Number: 105270060. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Beryllium
KW - Congresses and Conferences -- New Mexico
KW - Environmental Pollution
KW - New Mexico
SP - D89
EP - 91
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio
DO - 10.1080/15459620903158607
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105270060&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105239621
T1 - Analytical Performance Criteria. Standardized surface dust sampling methods for metals, with emphasis on beryllium.
AU - Ashley K
AU - Braybrooke G
AU - Jahn SD
AU - Brisson MJ
AU - White KT
Y1 - 2009/12//
N1 - Accession Number: 105239621. Language: English. Entry Date: 20100101. Revision Date: 20150711. Publication Type: Journal Article; tables/charts. Journal Subset: Biomedical; Double Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 101189458.
KW - Beryllium -- Analysis
KW - Dust -- Analysis
KW - Occupational Exposure -- Evaluation
SP - D97
EP - 100
JO - Journal of Occupational & Environmental Hygiene
JF - Journal of Occupational & Environmental Hygiene
JA - J OCCUP ENVIRON HYG
VL - 6
IS - 12
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1545-9624
AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
U2 - PMID: 19894170.
DO - 10.1080/15459620903022597
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105239621&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105267840
T1 - The impact of self-insuring for workers' compensation on the incidence rates of worker injury and illness.
AU - Asfaw A
AU - Pana-Cryan R
Y1 - 2009/12//
N1 - Accession Number: 105267840. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; equations & formulas; research; tables/charts. Journal Subset: Biomedical; Peer Reviewed; USA. NLM UID: 9504688.
KW - Insurance, Health
KW - Occupational Health
KW - Occupational-Related Injuries -- Epidemiology
KW - Worker's Compensation
KW - Adult
KW - Conceptual Framework
KW - Descriptive Statistics
KW - Female
KW - Human
KW - Male
KW - Middle Age
SP - 1466
EP - 1473
JO - Journal of Occupational & Environmental Medicine
JF - Journal of Occupational & Environmental Medicine
JA - J OCCUP ENVIRON MED
VL - 51
IS - 12
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - OBJECTIVE: There is moderate evidence that workers in experience-rated firms sustain less injuries when compared with workers in firms that are not experience rated. This study aims to provide more insight on this issue. METHODS: Panel data from the Bureau of Labor Statistics and National Academy of Social Insurance between 1999 and 2006 were used. A theoretical framework was developed, and a fixed effects vector decomposition model was estimated. RESULTS: Self-insuring was positively associated with relatively low worker injury and illness incidence rates when compared with insuring (including experience rating and manually rating). After controlling for workforce characteristics, industrial composition, firm size, and state-specific laws, states with an above the median percentage of self-insured firms had incidence rates that were lower than rates in states with a below the median percentage of self-insured firms. CONCLUSION: A higher degree of experience rating seems to better align the economic incentive to invest in prevention and the intended outcome of reducing worker injury and illness.
SN - 1076-2752
AD - Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Office of the Director, Suite 9200, Patriots Plaza, 395 E Street, SW, Washington, DC 20201; hqp0@cdc.gov
U2 - PMID: 19952789.
DO - 10.1097/JOM.0b013e3181c16373
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105267840&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 109851430
T1 - The human factors of home health care: a conceptual model for examining safety and quality concerns.
AU - Henriksen K
AU - Joseph A
AU - Zayas-Cabán T
Y1 - 2009/12//2009 Dec
N1 - Accession Number: 109851430. Language: English. Entry Date: 20100205. Revision Date: 20151008. Publication Type: Journal Article; tables/charts. Journal Subset: Health Services Administration; Peer Reviewed; USA. Special Interest: Home Health Care; Patient Safety. NLM UID: 101233393.
KW - Conceptual Framework
KW - Home Health Care -- Trends
KW - Human Error -- Prevention and Control
KW - Patient Safety
KW - Quality Improvement
KW - Caregivers
KW - Case Management
KW - Cognition Disorders
KW - Economics -- Trends
KW - Health Services Needs and Demand
KW - Health Status
KW - Home Environment
KW - Interpersonal Relations
KW - Outcomes (Health Care)
KW - Sensation Disorders
KW - Social Environment
KW - Systems Design
KW - Technology, Medical -- Trends
SP - 229
EP - 236
JO - Journal of Patient Safety
JF - Journal of Patient Safety
JA - J PATIENT SAF
VL - 5
IS - 4
CY - Baltimore, Maryland
PB - Lippincott Williams & Wilkins
AB - Objective: Increases in longevity, a growing elderly population, variation of skill and knowledge among home providers, and a steady migration of medical devices and technologies into the home are placing new demands on home heath care. The paper examines the human factors challenges associated with these converging trends. Methods: A growing literature base relevant to home health care is examined, and with the aid of a socio-technical systems model, the paper explores safety and quality concerns to which the converging trends are likely to give rise. Findings: The sensory, physical, and cognitive limitations of patients and their caregivers play a key role in the ability of patients to manage home health care needs. Other major components affecting successful home health care management are the nature of health care tasks undertaken, the design features of the physical environment, the medical devices and technologies used, the social and community environments, and distal but relevant external factors that shape the context of care. Home health care stakeholders can avoid foreseeable threats to safety and quality by recognizing that components need to be designed in a way that takes into account their interactions with one another and with the capabilities and limitations of patients and their providers. Conclusions: By examining the major components and interdependencies of the home health care delivery system, a human factors perspective offers insights into ways that safety and quality can be compromised and can help pave the way for new modes of thinking in home health care policy.
SN - 1549-8417
AD - Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, Maryland 20850, (301) 427-1331; Kerm.Henriksen@ahrq.hhs.gov
U2 - PMID: 22130216.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=109851430&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Wu, Zhongyu
AU - Lin, Zhichao
AU - Mackill, Pamela
AU - Wei, Cong
AU - Noonan, John
AU - Cherniack, James
AU - Gillis-Landrum, Deborah
T1 - Evaluation of food emergency response laboratories’ capability for 210Po analysis using proficiency test material with verifiable traceability.
JO - Journal of Radioanalytical & Nuclear Chemistry
JF - Journal of Radioanalytical & Nuclear Chemistry
Y1 - 2009/12//
VL - 282
IS - 3
M3 - Article
SP - 971
EP - 977
SN - 02365731
AB - Measurement capability and data comparability are essential for emergency response when analytical data from cooperative laboratories are used for risk assessment and post incident decision making. In this study, the current capability of food emergency response laboratories for the analysis of 210Po in water was evaluated using a proficiency test scheme in compliance with ISO-43 and ILAC G13 guidelines, which comprises a test sample preparation and verification protocol and an insightful statistical data evaluation. The results of performance evaluations on relative bias, value trueness, precision, false positive detection, minimum detection limit, and limit of quantification, are presented. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EMERGENCY management
KW - RISK assessment
KW - DECISION making
KW - TEST methods
KW - TESTING laboratories
KW - FOOD -- Analysis
KW - 210Po
KW - Food Emergency Response Network
KW - Proficiency test
KW - Traceability
N1 - Accession Number: 45506780; Wu, Zhongyu 1; Email Address: zhongyu.wu@fda.hhs.gov Lin, Zhichao 1 Mackill, Pamela 1 Wei, Cong 1 Noonan, John 1 Cherniack, James 1 Gillis-Landrum, Deborah 1; Affiliation: 1: Winchester Engineering and Analytical Center, Food and Drug Administration, 109 Holton Street, Winchester, MA 01890, USA; Source Info: Dec2009, Vol. 282 Issue 3, p971; Subject Term: EMERGENCY management; Subject Term: RISK assessment; Subject Term: DECISION making; Subject Term: TEST methods; Subject Term: TESTING laboratories; Subject Term: FOOD -- Analysis; Author-Supplied Keyword: 210Po; Author-Supplied Keyword: Food Emergency Response Network; Author-Supplied Keyword: Proficiency test; Author-Supplied Keyword: Traceability; NAICS/Industry Codes: 624230 Emergency and Other Relief Services; NAICS/Industry Codes: 922190 Other Justice, Public Order, and Safety Activities; NAICS/Industry Codes: 913190 Other municipal protective services; NAICS/Industry Codes: 912190 Other provincial protective services; NAICS/Industry Codes: 911290 Other federal protective services; NAICS/Industry Codes: 541380 Testing Laboratories; NAICS/Industry Codes: 621511 Medical Laboratories; Number of Pages: 7p; Illustrations: 1 Diagram, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1007/s10967-009-0286-1
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45506780&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Wear, Keith A.
T1 - Frequency dependence of average phase shift from human calcaneus in vitro.
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
Y1 - 2009/12//
VL - 126
IS - 6
M3 - Article
SP - 3291
EP - 3300
SN - 00014966
AB - If dispersion in a medium is weak and approximately linear with frequency (over the experimental band of frequencies), then it can be shown that the constant term in a polynomial representation of phase shift as a function of frequency can produce errors in measurements of phase-velocity differences in through-transmission, substitution experiments. A method for suppressing the effects of the constant phase shift in the context of the single-wave-model was tested on measurements from 30 cancellous human calcaneus samples in vitro. Without adjustment for constant phase shifts, the estimated phase velocity at 500 kHz was 1516±6 m/s (mean±standard error), and the estimated dispersion was -24±4 m/s MHz (mean±standard error). With adjustment for constant phase shifts, the estimated mean velocity decreased by 4–9 m/s, and the estimated magnitude of mean dispersion decreased by 50%–100%. The average correlation coefficient between the measured attenuation coefficient and frequency was 0.997±0.0026 (mean±standard deviation), suggesting that the signal for each sample was dominated by one wave. A single-wave, linearly dispersive model conformed to measured complex transfer functions from the 30 cancellous-bone samples with an average root-mean-square error of 1.9%±1.0%. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of the Acoustical Society of America is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TRANSFER functions (Mathematics)
KW - SPEED of sound
KW - STANDARD deviations
KW - SCATTERING (Physics)
KW - HEEL bone
KW - MATHEMATICAL physics
N1 - Accession Number: 46745280; Wear, Keith A. 1; Email Address: keith.wear@fda.hhs.gov; Affiliation: 1: Center for Devices and Radiological Health, U. S. Food and Drug Administration, Silver Spring, Maryland 20993; Source Info: Dec2009, Vol. 126 Issue 6, p3291; Subject Term: TRANSFER functions (Mathematics); Subject Term: SPEED of sound; Subject Term: STANDARD deviations; Subject Term: SCATTERING (Physics); Subject Term: HEEL bone; Subject Term: MATHEMATICAL physics; Number of Pages: 10p; Illustrations: 2 Charts, 12 Graphs; Document Type: Article
L3 - 10.1121/1.3257550
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=46745280&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - LeBlanc, A. J.
AU - Cumpston, J. L.
AU - Chen, B. T.
AU - Frazer, D.
AU - Castranova, V.
AU - Nurkiewicz, T. R.
T1 - Nanoparticle Inhalation Impairs Endothelium-Dependent Vasodilation in Subepicardial Arterioles.
JO - Journal of Toxicology & Environmental Health: Part A
JF - Journal of Toxicology & Environmental Health: Part A
Y1 - 2009/12//
VL - 72
IS - 24
M3 - Article
SP - 1576
EP - 1584
SN - 15287394
AB - Exposure to fine particulate matter (PM, mean aerodynamic diameter ≤2.5 μm) has been shown to be a risk factor for cardiovascular disease mortality and may contribute to acute coronary events such as myocardial infarction (MI). There is sufficient reason to believe that smaller particles, such as nanoparticles, might be even more detrimental than larger sized particles due to their increased surface area and higher pulmonary deposition. Our laboratory showed that nanoparticle inhalation impairs endothelium-dependent arteriolar vasodilation in skeletal muscle. However, it is not known whether coronary microvascular endothelial function is affected in a similar manner. Rats were exposed to filtered air (control) or TiO2 nanoparticles (primary particle diameter, ∼21 nm) via inhalation at concentrations that produced measured depositions (10 μg) relevant to ambient air pollution. Subepicardial arterioles (∼150 μm in diameter) were isolated and responses to transmural pressure, flow-induced dilation (FID), acetylcholine (ACh), the Ca2+ ionophore A23187, and sodium nitroprusside (SNP) were assessed. Myogenic responsiveness was preserved between groups. In addition, there was no difference in the vasodilation to SNP, signifying that smooth muscle sensitivity to nitric oxide (NO) is unaffected by nano-TiO2 exposure. However, inhalation of nano-TiO2 produced an increase in spontaneous tone in coronary arterioles and also impaired endothelium-dependent FID. In addition, ACh-induced and A23187-induced vasodilation was also blunted in arterioles after inhalation of nano-TiO2. Data showed that nanoparticle exposure significantly impairs endothelium-dependent vasodilation in subepicardial arterioles. Such disturbances in coronary microvascular function are consistent with the cardiac events associated with particle pollution exposure. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Toxicology & Environmental Health: Part A is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PARTICULATE matter
KW - CARDIOVASCULAR diseases
KW - DISEASES -- Risk factors
KW - MYOCARDIAL infarction
KW - NANOPARTICLES
KW - ATMOSPHERIC deposition
KW - VASODILATION
KW - SMOOTH muscle
KW - MORTALITY
KW - ACETYLCHOLINE
N1 - Accession Number: 49234441; LeBlanc, A. J. 1,2 Cumpston, J. L. 3 Chen, B. T. 3 Frazer, D. 2,3 Castranova, V. 3 Nurkiewicz, T. R. 1,2,4; Email Address: tnurkiewicz@hsc.wvu.edu; Affiliation: 1: Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia., USA. 2: Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia., USA. 3: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. 4: Department of Neurobiology and Anatomy, West Virginia University School of Medicine, Morgantown, West Virginia., USA.; Source Info: Dec2009, Vol. 72 Issue 24, p1576; Subject Term: PARTICULATE matter; Subject Term: CARDIOVASCULAR diseases; Subject Term: DISEASES -- Risk factors; Subject Term: MYOCARDIAL infarction; Subject Term: NANOPARTICLES; Subject Term: ATMOSPHERIC deposition; Subject Term: VASODILATION; Subject Term: SMOOTH muscle; Subject Term: MORTALITY; Subject Term: ACETYLCHOLINE; Number of Pages: 9p; Illustrations: 1 Chart, 5 Graphs; Document Type: Article
L3 - 10.1080/15287390903232467
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=49234441&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shijun Wang
AU - Jianhua Yao
AU - Jiamin Liu
AU - Petrick, Nicholas
AU - Van Uitert, Robert L.
AU - Periaswamy, Senthil
AU - Summers, Ronald M.
T1 - Registration of prone and supine CT colonography scans using correlation optimized warping and canonical correlation analysis.
JO - Medical Physics
JF - Medical Physics
Y1 - 2009/12//
VL - 36
IS - 12
M3 - Article
SP - 5595
EP - 5603
SN - 00942405
AB - Purpose: In computed tomographic colonography (CTC), a patient will be scanned twice—Once supine and once prone—to improve the sensitivity for polyp detection. To assist radiologists in CTC reading, in this paper we propose an automated method for colon registration from supine and prone CTC scans. Methods: We propose a new colon centerline registration method for prone and supine CTC scans using correlation optimized warping (COW) and canonical correlation analysis (CCA) based on the anatomical structure of the colon. Four anatomical salient points on the colon are first automatically distinguished. Then correlation optimized warping is applied to the segments defined by the anatomical landmarks to improve the global registration based on local correlation of segments. The COW method was modified by embedding canonical correlation analysis to allow multiple features along the colon centerline to be used in our implementation. Results: We tested the COW algorithm on a CTC data set of 39 patients with 39 polyps (19 training and 20 test cases) to verify the effectiveness of the proposed COW registration method. Experimental results on the test set show that the COW method significantly reduces the average estimation error in a polyp location between supine and prone scans by 67.6%, from 46.27±52.97 to 14.98 mm±11.41 mm, compared to the normalized distance along the colon centerline algorithm (p<0.01). Conclusions: The proposed COW algorithm is more accurate for the colon centerline registration compared to the normalized distance along the colon centerline method and the dynamic time warping method. Comparison results showed that the feature combination of z-coordinate and curvature achieved lowest registration error compared to the other feature combinations used by COW. The proposed method is tolerant to centerline errors because anatomical landmarks help prevent the propagation of errors across the entire colon centerline. [ABSTRACT FROM AUTHOR]
AB - Copyright of Medical Physics is the property of American Association of Physicists in Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COLON (Anatomy) -- Diseases
KW - DIAGNOSIS
KW - SUPINE position
KW - POLYPS (Pathology)
KW - RADIOLOGISTS
KW - DIAGNOSTIC imaging
KW - MEDICAL physics
KW - canonical correlation analysis
KW - colon registration
KW - correlation optimized warping
KW - dynamic time warping
KW - virtual colonoscopy
N1 - Accession Number: 45412038; Shijun Wang 1; Email Address: wangshi@cc.nih.gov Jianhua Yao 1 Jiamin Liu 1 Petrick, Nicholas 2 Van Uitert, Robert L. 3 Periaswamy, Senthil 3 Summers, Ronald M. 1; Email Address: rms@nih.gov; Affiliation: 1: Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Building 10, Room 1C368X, MSC 1182, Bethesda, Maryland 20892-1182. 2: NIBIB/CDRH Laboratory for the Assessment of Medical Imaging Systems, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993-0002. 3: iCAD Inc., 98 Spit Brook Road, Suite 100, Nashua, New Hampshire 03062.; Source Info: Dec2009, Vol. 36 Issue 12, p5595; Subject Term: COLON (Anatomy) -- Diseases; Subject Term: DIAGNOSIS; Subject Term: SUPINE position; Subject Term: POLYPS (Pathology); Subject Term: RADIOLOGISTS; Subject Term: DIAGNOSTIC imaging; Subject Term: MEDICAL physics; Author-Supplied Keyword: canonical correlation analysis; Author-Supplied Keyword: colon registration; Author-Supplied Keyword: correlation optimized warping; Author-Supplied Keyword: dynamic time warping; Author-Supplied Keyword: virtual colonoscopy; NAICS/Industry Codes: 621512 Diagnostic Imaging Centers; NAICS/Industry Codes: 811219 Other Electronic and Precision Equipment Repair and Maintenance; NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 9p; Illustrations: 2 Color Photographs, 1 Black and White Photograph, 9 Charts, 1 Graph; Document Type: Article
L3 - 10.1118/1.3259727
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45412038&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Sassi, Atfa
AU - Brichacek, Beda
AU - Hieny, Sara
AU - Yarovinsky, Felix
AU - Golding, Hana
AU - Grivel, Jean-Charles
AU - Sher, Alan
AU - Margolis, Leonid
T1 - Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo
JO - Microbes & Infection
JF - Microbes & Infection
Y1 - 2009/12//
VL - 11
IS - 14/15
M3 - Article
SP - 1106
EP - 1113
SN - 12864579
AB - Abstract: Critical events of HIV-1 pathogenesis occur in lymphoid tissues where HIV-1 is typically accompanied by infections with other pathogens (HIV co-pathogens). Co-pathogens greatly affect the clinical course of the disease and the transmission of HIV. The apicomplexan parasite Toxoplasma gondii is a common HIV co-pathogen associated with AIDS development. Here, we examined the interaction of T. gondii and HIV in coinfected human lymphoid tissue ex vivo. Both pathogens readily replicate in ex vivo infected blocks of human tonsillar tissue. Surprisingly, we found that live T. gondii preferentially inhibits R5 HIV-1 replication in coinfected tissues. This effect is reproduced by treatment of the tissue blocks with recombinant C-18, a T. gondii-encoded cyclophilin that binds to CCR5. These ex vivo findings raise the possibility that, in addition to being a co-factor in HIV disease, T. gondii may influence the outcome of viral infection by preferentially suppressing R5 variants. [Copyright &y& Elsevier]
AB - Copyright of Microbes & Infection is the property of Elsevier Science Publishing Company, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Cyclophilin
KW - Ex vivo
KW - HIV
KW - Human lymphoid tissue
KW - Toxoplasma gondii
N1 - Accession Number: 45557200; Sassi, Atfa 1; Brichacek, Beda 1; Hieny, Sara 2; Yarovinsky, Felix 3; Golding, Hana 4; Grivel, Jean-Charles 1; Email Address: grivelj@mail.nih.gov; Sher, Alan 2; Margolis, Leonid 1; Affiliations: 1: Section of Intercellular Interactions, Program of Physical Biology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA; 2: Immunobiology Section, Laboratory of Parasitic Diseases, National institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA; 3: Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; 4: Laboratory of Retrovirus Research, Federal Food and Drug Administration, Bethesda, MD 20892, USA; Issue Info: Dec2009, Vol. 11 Issue 14/15, p1106; Author-Supplied Keyword: Cyclophilin; Author-Supplied Keyword: Ex vivo; Author-Supplied Keyword: HIV; Author-Supplied Keyword: Human lymphoid tissue; Author-Supplied Keyword: Toxoplasma gondii; Number of Pages: 8p; Document Type: Article
L3 - 10.1016/j.micinf.2009.08.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45557200&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Lu, Benson C.
AU - Cebrian, Cristina
AU - Xuan Chi
AU - Kuure, Satu
AU - Kuo, Richard
AU - Bates, Carlton M.
AU - Arber, Silvia
AU - Hassell, John
AU - MacNeil, Lesley
AU - Hoshi, Masato
AU - Jain, Sanjay
AU - Asai, Naoya
AU - Takahashi, Masahide
AU - Schmidt-Ott, Kai M.
AU - Barasch, Jonathan
AU - D'Agati, Vivette
AU - Costantini, Frank
T1 - Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
JO - Nature Genetics
JF - Nature Genetics
Y1 - 2009/12//
VL - 41
IS - 12
M3 - Article
SP - 1295
EP - 1302
PB - Nature Publishing Group
SN - 10614036
AB - Glial cell line–derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in the ureteric bud tips. Mice lacking both Etv4 alleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney development fails completely in double homozygotes. We identified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4, Myb, Met and Mmp14. Thus, Etv4 and Etv5 are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis. [ABSTRACT FROM AUTHOR]
AB - Copyright of Nature Genetics is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL lines
KW - NEUROPHYSIOLOGY
KW - TRANSCRIPTION factors
KW - PROTEIN-tyrosine kinase
KW - MORPHOGENESIS
KW - KIDNEYS
KW - MICE
N1 - Accession Number: 45403984; Lu, Benson C. 1 Cebrian, Cristina 1 Xuan Chi 1,2 Kuure, Satu 1 Kuo, Richard 1 Bates, Carlton M. 3 Arber, Silvia 4 Hassell, John 5 MacNeil, Lesley 5,6 Hoshi, Masato 7 Jain, Sanjay 7 Asai, Naoya 8 Takahashi, Masahide 8 Schmidt-Ott, Kai M. 9,10 Barasch, Jonathan 9 D'Agati, Vivette 11 Costantini, Frank 1; Email Address: fdc3@columbia.edu; Affiliation: 1: Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA 2: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA 3: Division of Nephrology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA 4: Neurobiology, Biozentrum, University of Basel, Basel, Switzerland 5: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada 6: Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA 7: Department of Medicine, Renal Division, Washington University School of Medicine, St. Louis, Missouri, USA 8: Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan 9: Departments of Medicine, New York, New York, USA 10: Max-Delbrück Center for Molecular Medicine, Berlin, Germany 11: Pathology, Columbia University Medical Center, New York, New York, USA; Source Info: Dec2009, Vol. 41 Issue 12, p1295; Subject Term: CELL lines; Subject Term: NEUROPHYSIOLOGY; Subject Term: TRANSCRIPTION factors; Subject Term: PROTEIN-tyrosine kinase; Subject Term: MORPHOGENESIS; Subject Term: KIDNEYS; Subject Term: MICE; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 8p; Illustrations: 7 Diagrams, 1 Chart; Document Type: Article
L3 - 10.1038/ng.476
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45403984&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105260294
T1 - Injuries and injury prevention among indigenous children and young people.
AU - Berger LR
AU - Wallace LJ
AU - Bill NM
Y1 - 2009/12//2009 Dec
N1 - Accession Number: 105260294. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0401126.
KW - Developing Countries
KW - Indigenous Peoples -- Statistics and Numerical Data
KW - Preventive Health Care -- Methods
KW - Wounds and Injuries -- Epidemiology
KW - Wounds and Injuries -- Prevention and Control
KW - Accidental Falls
KW - Accidents, Traffic -- Prevention and Control
KW - Accidents, Traffic
KW - Adolescence
KW - Demography
KW - Alcohol Drinking
KW - Australia
KW - Burns -- Epidemiology
KW - Canada
KW - Child
KW - Child Abuse -- Prevention and Control
KW - Child Abuse
KW - Culture
KW - Drowning -- Epidemiology
KW - Homicide
KW - Native Americans -- Statistics and Numerical Data
KW - New Zealand
KW - Program Development
KW - Program Evaluation
KW - Suicide, Attempted -- Prevention and Control
KW - Suicide, Attempted
KW - United States
KW - Young Adult
SP - 1519
EP - 1537
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
JA - PEDIATR CLIN NORTH AM
VL - 56
IS - 6
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Throughout the world, injuries and violence are a leading cause of mortality and suffering among Indigenous communities. Among American Indian and Alaska Native children aged 1 to 19 years, 71% of deaths are from injuries. Motor-vehicle accidents, attempted suicide, and interpersonal violence are the most common causes of injuries in highly industrialized countries. For Indigenous populations in middle- and low-income countries, trauma caused by motor-vehicle accidents, agricultural injuries, interpersonal violence, child labor, and the ravages of war are priorities for intervention. To be effective, injury-prevention efforts should be based on scientific evidence, be developmentally and culturally appropriate, and draw on the inherent strengths of Indigenous communities.Copyright © 2009 by Elsevier Inc.
SN - 0031-3955
AD - Department of Pediatrics, University of New Mexico School of Medicine, 1 University of New Mexico, Albuquerque, NM 87106, USA; Injury Prevention Program, Indian Health Service, OEHE-EHS-TMP 610, 801 Thompson Ave, Suite 120, Rockville, MD 20852, USA.
U2 - PMID: 19962034.
DO - 10.1016/j.pcl.2009.09.016
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105260294&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105260296
T1 - History, law, and policy as a foundation for health care delivery for american Indian and alaska native children.
AU - Thierry J
AU - Brenneman G
AU - Rhoades E
AU - Chilton L
Y1 - 2009/12//2009 Dec
N1 - Accession Number: 105260296. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Peer Reviewed; USA. Special Interest: Pediatric Care. NLM UID: 0401126.
KW - Health Care Delivery -- History
KW - Health Care Delivery -- Legislation and Jurisprudence
KW - Health Care Delivery -- Standards
KW - Health Care Delivery -- Trends
KW - Health Policy -- History
KW - Health Policy -- Legislation and Jurisprudence
KW - Native Americans -- History
KW - Native Americans -- Legislation and Jurisprudence
KW - Policy Making
KW - Health Services, Indigenous -- History
KW - Health Services, Indigenous -- Legislation and Jurisprudence
KW - Alaska
KW - Alcohol Drinking
KW - Child
KW - Culture
KW - Disease Outbreaks -- Prevention and Control
KW - Education -- History
KW - Education -- Legislation and Jurisprudence
KW - Education -- Standards
KW - Education -- Trends
KW - Health Promotion
KW - History
KW - Eskimos
KW - Legislation -- History
KW - United States
SP - 1539
EP - 1559
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
JA - PEDIATR CLIN NORTH AM
VL - 56
IS - 6
CY - Philadelphia, Pennsylvania
PB - W B Saunders
AB - Most American Indian and Alaska Native Children (AIAN) receive health care that is based on the unique historical legacy of tribal treaty obligations and a trust relationship of sovereign nation to sovereign nation. From colonial America to the early 21st century, the wellbeing of AIAN children has been impacted as federal laws were crafted for the health, education and wellbeing of its AIAN citizens. Important public laws are addressed in this article, highlighting the development of the Indian Health Service (IHS), a federal agency designed to provide comprehensive clinical and public health services to citizens of federally recognized tribes. The context during which various acts were made into law are described to note the times during which the policy making process took place. Policies internal and external to the IHS are summarized, widening the lens spanning the past 200 years and into the future of these first nations' youngest members.Copyright © 2009 by Elsevier Inc.
SN - 0031-3955
AD - Office of Clinical and Preventive Services, Indian Health Service, 801 Thompson Avenue, Suite 300, Room 313, Rockville, MD 20852, USA.
U2 - PMID: 19962035.
DO - 10.1016/j.pcl.2009.09.018
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105260296&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Bellier, Audrey
AU - Chang-Shi Chen
AU - Cheng-Yuan Kao
AU - Cinar, Hediye N.
AU - Aroian, Raffi V.
T1 - Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans.
JO - PLoS Pathogens
JF - PLoS Pathogens
Y1 - 2009/12//
VL - 5
IS - 12
M3 - Article
SP - 1
EP - 13
PB - Public Library of Science
SN - 15537366
AB - Pore-forming toxins (PFTs) are by far the most abundant bacterial protein toxins and are important for the virulence of many important pathogens. As such, cellular responses to PFTs critically modulate host-pathogen interactions. Although many cellular responses to PFTs have been recorded, little is understood about their relevance to pathological or defensive outcomes. To shed light on this important question, we have turned to the only genetic system for studying PFT-host interactions—Caenorhabditis elegans intoxication by Crystal (Cry) protein PFTs. We mutagenized and screened for C. elegans mutants resistant to a Cry PFT and recovered one mutant. Complementation, sequencing, transgenic rescue, and RNA interference data demonstrate that this mutant eliminates a gene normally involved in repression of the hypoxia (low oxygen response) pathway. We find that up-regulation of the C. elegans hypoxia pathway via the inactivation of three different genes that normally repress the pathway results in animals resistant to Cry PFTs. Conversely, mutation in the central activator of the hypoxia response, HIF-1, suppresses this resistance and can result in animals defective in PFT defenses. These results extend to a PFT that attacks mammals since up-regulation of the hypoxia pathway confers resistance to Vibrio cholerae cytolysin (VCC), whereas down-regulation confers hypersusceptibility. The hypoxia PFT defense pathway acts cell autonomously to protect the cells directly under attack and is different from other hypoxia pathway stress responses. Two of the downstream effectors of this pathway include the nuclear receptor nhr-57 and the unfolded protein response. In addition, the hypoxia pathway itself is induced by PFT, and low oxygen is protective against PFT intoxication. These results demonstrate that hypoxia and induction of the hypoxia response protect cells against PFTs, and that the cellular environment can be modulated via the hypoxia pathway to protect against the most prevalent class of weapons used by pathogenic bacteria. [ABSTRACT FROM AUTHOR]
AB - Copyright of PLoS Pathogens is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANOXEMIA
KW - CAENORHABDITIS elegans
KW - MICROBIAL toxins
KW - IMMUNOLOGIC diseases
KW - PROTEIN binding
KW - PROTEINS -- Affinity labeling
N1 - Accession Number: 47256265; Bellier, Audrey 1 Chang-Shi Chen 1,2 Cheng-Yuan Kao 1 Cinar, Hediye N. 3 Aroian, Raffi V. 1; Email Address: raroian@ucsd.edu; Affiliation: 1: Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, United States of America 2: Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3: United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Virulence Assessment, Laurel, Maryland, United States of America; Source Info: Dec2009, Vol. 5 Issue 12, p1; Subject Term: ANOXEMIA; Subject Term: CAENORHABDITIS elegans; Subject Term: MICROBIAL toxins; Subject Term: IMMUNOLOGIC diseases; Subject Term: PROTEIN binding; Subject Term: PROTEINS -- Affinity labeling; Number of Pages: 13p; Illustrations: 3 Black and White Photographs, 2 Charts, 4 Graphs; Document Type: Article
L3 - 10.1371/journal.ppat.1000689
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47256265&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hopf, Nancy B.
AU - Ruder, Avima M.
AU - Succop, Paul
T1 - Background levels of polychlorinated biphenyls in the U.S. population
JO - Science of the Total Environment
JF - Science of the Total Environment
Y1 - 2009/12//
VL - 407
IS - 24
M3 - Article
SP - 6109
EP - 6119
SN - 00489697
AB - Abstract: Background: Polychlorinated biphenyl (PCB) exposures are encountered by the general public by eating contaminated food or living near a previously operating PCB factory or hazardous waste site. PCBs affect the immune, reproductive, nervous, and endocrine systems and are carcinogens. PCBs were banned in the United States in 1977. For public health, it is important to be able to estimate individual risk, especially for vulnerable populations, to monitor the decline in risk over time and to alert the public health community if spikes occur in PCB exposures, by measuring serum PCB levels. The historical decline in PCB exposures cannot be documented within a repeatedly tested general population, since there is no such population. Therefore, our aim was to model serum PCB levels in the US general population over time using published data. Methods: Models were developed based on 45 publications providing 16,914 background PCB levels in sera collected 1963–2003. Multiple linear regression and exponential decay were used to model the summary PCB levels. Results: Background levels of higher-chlorinated PCBs (five or more chlorines) in sera increased before 1979 and decreased after 1979; a quadratic model was the best fit. However, the exponential decay model explained better the low PCB serum levels still seen in the general population. For lower-chlorinated serum PCBs, no increase or decrease was shown (1.7ppb for all years). Conclusions: Limitations for both models were lack of repeated measures, non-randomly selected study participants, selected years, concentration on geographic areas centered on PCB waste sites, lack of adjustment for BMI or for laboratory methods. Despite the limitations, this analysis shows that background PCB levels in the general population are still of concern. Future work should focus on uncertainties governing how to interpret the levels with respect to possible long term health effects. [Copyright &y& Elsevier]
AB - Copyright of Science of the Total Environment is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - POLYCHLORINATED biphenyls
KW - FOOD contamination
KW - HAZARDOUS wastes
KW - REGRESSION analysis
KW - SERUM
KW - ESTIMATES
KW - SCIENCE publishing
KW - POPULATION
KW - UNITED States
KW - Background levels
KW - PCBs
KW - Polychlorinated biphenyls
KW - Serum PCB
N1 - Accession Number: 44939326; Hopf, Nancy B. 1; Email Address: nancybhopf@gmail.com Ruder, Avima M. 2 Succop, Paul 1; Affiliation: 1: University of Cincinnati, Department of Environmental Health, 123 Kettering PO Box 670056 Cincinnati, Ohio 45267, United States 2: Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, Cincinnati, Ohio 45226, United States; Source Info: Dec2009, Vol. 407 Issue 24, p6109; Subject Term: POLYCHLORINATED biphenyls; Subject Term: FOOD contamination; Subject Term: HAZARDOUS wastes; Subject Term: REGRESSION analysis; Subject Term: SERUM; Subject Term: ESTIMATES; Subject Term: SCIENCE publishing; Subject Term: POPULATION; Subject Term: UNITED States; Author-Supplied Keyword: Background levels; Author-Supplied Keyword: PCBs; Author-Supplied Keyword: Polychlorinated biphenyls; Author-Supplied Keyword: Serum PCB; NAICS/Industry Codes: 562211 Hazardous Waste Treatment and Disposal; NAICS/Industry Codes: 562112 Hazardous Waste Collection; NAICS/Industry Codes: 562110 Waste collection; NAICS/Industry Codes: 562910 Remediation Services; NAICS/Industry Codes: 511130 Book Publishers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 11p; Document Type: Article
L3 - 10.1016/j.scitotenv.2009.08.035
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44939326&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, Baozhong
AU - Yin, Jun-Jie
AU - Bilski, Piotr J.
AU - Chignell, Colin F.
AU - Roberts, Joan E.
AU - He, Yu-Ying
T1 - Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/12//
VL - 241
IS - 2
M3 - Article
SP - 163
EP - 172
SN - 0041008X
AB - Abstract: Nanoparticles have been explored recently as an efficient means of delivering photosensitizers for cancer diagnosis and photodynamic therapy (PDT). Silicon phthalocyanine 4 (Pc4) is currently being clinically tested as a photosensitizer for PDT. Unfortunately, Pc4 aggregates in aqueous solutions, which dramatically reduces its PDT efficacy and therefore limits its clinical application. We have encapsulated Pc4 using silica nanoparticles (Pc4SNP), which not only improved the aqueous solubility, stability, and delivery of the photodynamic drug but also increased its photodynamic efficacy compared to free Pc4 molecules. Pc4SNP generated photo-induced singlet oxygen more efficiently than free Pc4 as measured by chemical probe and EPR trapping techniques. Transmission electron microscopy and dynamic light scattering measurements showed that the size of the particles is in the range of 25–30 nm. Cell viability measurements demonstrated that Pc4SNP was more phototoxic to A375 or B16-F10 melanoma cells than free Pc4. Pc4SNP photodamaged melanoma cells primarily through apoptosis. Irradiation of A375 cells in the presence of Pc4SNP resulted in a significant increase in intracellular protein-derived peroxides, suggesting a Type II (singlet oxygen) mechanism for phototoxicity. More Pc4SNP than free Pc4 was localized in the mitochondria and lysosomes. Our results show that these stable, monodispersed silica nanoparticles may be an effective new formulation for Pc4 in its preclinical and clinical studies. We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - PHOTOCHEMOTHERAPY
KW - APOPTOSIS
KW - LIGHT -- Scattering
KW - MELANOMA
KW - MICROENCAPSULATION
KW - SILICA
KW - NANOSILICON
KW - PHOTOSENSITIZERS
KW - CANCER -- Diagnosis
KW - PHTHALOCYANINES
KW - CANCER cells
KW - 2,2,6,6-tetramethyl-4-piperidone ( TEMP )
KW - 2,2,6,6-tetramethyl-4-piperidone-N-oxyl radical ( TEMPO )
KW - 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ( MTS )
KW - 9,10-anthracenediyl-bis(methylene)dimalonic acid ( ABMDMA )
KW - Apoptosis
KW - Dulbecco's Modified Eagle's Medium ( DMEM )
KW - Dynamic light scattering ( DLS )
KW - electron paramagnetic resonance ( EPR )
KW - fetal bovine serum ( FBS )
KW - Melanoma
KW - Nanoparticles
KW - phosphate buffered saline ( PBS )
KW - Photodynamic therapy
KW - photodynamic therapy ( PDT )
KW - Phthalocyanine
KW - reactive oxygen species ( ROS )
KW - room temperature ( RT )
KW - Singlet oxygen
KW - Transmission electron microscopy ( TEM )
KW - triethoxyvinylsilane ( TEVS )
N1 - Accession Number: 44992832; Zhao, Baozhong 1 Yin, Jun-Jie 2 Bilski, Piotr J. 1 Chignell, Colin F. 1 Roberts, Joan E. 3 He, Yu-Ying 4; Email Address: yyhe@medicine.bsd.uchicago.edu; Affiliation: 1: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA 2: Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA 3: Fordham University, Department of Natural Sciences, Lincoln Center, NY, USA 4: Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; Source Info: Dec2009, Vol. 241 Issue 2, p163; Subject Term: PHOTOCHEMOTHERAPY; Subject Term: APOPTOSIS; Subject Term: LIGHT -- Scattering; Subject Term: MELANOMA; Subject Term: MICROENCAPSULATION; Subject Term: SILICA; Subject Term: NANOSILICON; Subject Term: PHOTOSENSITIZERS; Subject Term: CANCER -- Diagnosis; Subject Term: PHTHALOCYANINES; Subject Term: CANCER cells; Author-Supplied Keyword: 2,2,6,6-tetramethyl-4-piperidone ( TEMP ); Author-Supplied Keyword: 2,2,6,6-tetramethyl-4-piperidone-N-oxyl radical ( TEMPO ); Author-Supplied Keyword: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ( MTS ); Author-Supplied Keyword: 9,10-anthracenediyl-bis(methylene)dimalonic acid ( ABMDMA ); Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: Dulbecco's Modified Eagle's Medium ( DMEM ); Author-Supplied Keyword: Dynamic light scattering ( DLS ); Author-Supplied Keyword: electron paramagnetic resonance ( EPR ); Author-Supplied Keyword: fetal bovine serum ( FBS ); Author-Supplied Keyword: Melanoma; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: phosphate buffered saline ( PBS ); Author-Supplied Keyword: Photodynamic therapy; Author-Supplied Keyword: photodynamic therapy ( PDT ); Author-Supplied Keyword: Phthalocyanine; Author-Supplied Keyword: reactive oxygen species ( ROS ); Author-Supplied Keyword: room temperature ( RT ); Author-Supplied Keyword: Singlet oxygen; Author-Supplied Keyword: Transmission electron microscopy ( TEM ); Author-Supplied Keyword: triethoxyvinylsilane ( TEVS ); NAICS/Industry Codes: 325130 Synthetic Dye and Pigment Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 212323 Sand and gravel mining and quarrying; NAICS/Industry Codes: 212322 Industrial Sand Mining; Number of Pages: 10p; Document Type: Article
L3 - 10.1016/j.taap.2009.08.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44992832&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Scheri, Richard C.
AU - Lee, Junga
AU - Barofsky, Douglas F.
AU - Curtis, Lawrence R.
T1 - Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/12//
VL - 191
IS - 1
M3 - Article
SP - 20
EP - 25
SN - 03784274
AB - Abstract: Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B type I (SR-BI) of the sinusoidal surface. A variety of tissues express scavenger receptor class B type II (SR-BII) and this protein was identified as a splice variant from the SR-BI gene. Although the function of SR-BII has not been elucidated it may play a role in CH homeostasis and trafficking distinctly different than SR-BI. Western blotting demonstrated that a single dose of CD promoted subcellular distribution of SR-BII to murine hepatic microsomes about 2.2-fold when compared to controls without effect on liver crude membrane SR-BII content. This was consistent with increased vesicular CH trafficking. Relative quantification of hepatic cytosolic proteins in a fraction that sequestered [14C]CH by mass spectrometry (MS) indicated no role for cytosolic CH binding proteins in CD altered CH homeostasis. Western blotting verified no effect of CD on liver fatty acid-binding protein (L-FABP) in cytosol. MS detected a statistically significant increase in myosin-9, which was also consistent with increased vesicular trafficking. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Chlordecone
KW - Microsomes
KW - Excretion
KW - Cholesterol
KW - Carrier proteins
KW - ATP-binding cassette transporters
KW - Myosin
KW - Mice as laboratory animals
KW - Western immunoblotting
KW - Scavenger receptor class B type II
N1 - Accession Number: 45069530; Scheri, Richard C. 1; Lee, Junga 2; Barofsky, Douglas F. 3; Curtis, Lawrence R. 4; Email Address: larry.curtis@oregonstate.edu; Affiliations: 1: Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; 2: Department of Civil and Environmental Engineering, Sungkyunkwan University, Natural Sciences Campus, Jangan-gu, Suwon, Gyeonggi 440-746, Korea; 3: Department of Chemistry, Oregon State University, Corvallis, OR, United States; 4: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97333, United States; Issue Info: Dec2009, Vol. 191 Issue 1, p20; Thesaurus Term: Chlordecone; Thesaurus Term: Microsomes; Subject Term: Excretion; Subject Term: Cholesterol; Subject Term: Carrier proteins; Subject Term: ATP-binding cassette transporters; Subject Term: Myosin; Subject Term: Mice as laboratory animals; Subject Term: Western immunoblotting; Author-Supplied Keyword: Scavenger receptor class B type II; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.toxlet.2009.07.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45069530&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Cho, Wan-Seob
AU - Kim, Seungryul
AU - Han, Beom Seok
AU - Son, Woo Chan
AU - Jeong, Jayoung
T1 - Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100nm-sized PEG-coated gold nanoparticles
JO - Toxicology Letters
JF - Toxicology Letters
Y1 - 2009/12//
VL - 191
IS - 1
M3 - Article
SP - 96
EP - 102
SN - 03784274
AB - Abstract: Gold nanoparticles (AuNPs) have been widely used in various biomedical applications for photothermal therapy, imaging and drug delivery. Although AuNPs have been recognized as a biologically safe material, very little is known about their molecular and cellular effects. To evaluate the gene expression profile and mechanism of the molecular level of polyethylene glycol (PEG)-coated AuNPs and the effect of particle size, we applied an expression profiling approach. PEG-coated AuNPs of different particle sizes, 4 and 100nm, were intravenously administered to BALB/c mice (4.26mg/kg, body weight). Thirty minutes after injection of AuNPs, the mice were sacrificed and liver tissues were removed. Then, pathological examination and microarray analysis were performed on the liver tissues. Histology of the liver tissues did not indicate any pathological changes in all treatment groups. Only 0.38% (170 genes) and 0.50% (224 genes) of the total genes (45,000 genes) were significantly induced by the treatment of 4 or 100nm AuNPs, respectively. In addition, the 4 and 100nm AuNPs treatment groups shared 67.1% and 50.9% of the significantly changed genes, respectively. Commonly expressed genes by a single intravenous injection of 4 or 100nm AuNPs were categorized as apoptosis, cell cycle, inflammation, and metabolic process. In the specifically expressed genes of 4 or 100nm AuNPs, although the genes were different each other, 4 and 100nm AuNPs showed similar gene categories such as cell cycle, response to stress, signal transduction, and metabolic process. Therefore, we can conclude that 4 and 100nm AuNPs showed similar biological effects on liver tissues of mice. [Copyright &y& Elsevier]
AB - Copyright of Toxicology Letters is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Particle size distribution
KW - Gene expression
KW - Liver
KW - Colloidal gold
KW - Protective coatings
KW - Polyethylene glycol
KW - Intravenous injections
KW - Phototherapy
KW - Mice as laboratory animals
KW - Gene expression profile
KW - Gold nanoparticles
KW - Intravenous injection
KW - Size of nanoparticles
N1 - Accession Number: 45069541; Cho, Wan-Seob 1; Kim, Seungryul 2; Han, Beom Seok 2; Son, Woo Chan 3; Jeong, Jayoung 4; Email Address: jjy_kfda@kfda.go.kr; Affiliations: 1: ELEGI/Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK; 2: Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea; 3: Department of Pathology, Huntingdon Life Sciences, Woolley Road, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, UK; 4: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea; Issue Info: Dec2009, Vol. 191 Issue 1, p96; Thesaurus Term: Particle size distribution; Subject Term: Gene expression; Subject Term: Liver; Subject Term: Colloidal gold; Subject Term: Protective coatings; Subject Term: Polyethylene glycol; Subject Term: Intravenous injections; Subject Term: Phototherapy; Subject Term: Mice as laboratory animals; Author-Supplied Keyword: Gene expression profile; Author-Supplied Keyword: Gold nanoparticles; Author-Supplied Keyword: Intravenous injection; Author-Supplied Keyword: Size of nanoparticles; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.toxlet.2009.08.010
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=eih&AN=45069541&site=ehost-live&scope=site
DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Masilamani, Madhan
AU - Peruzzi, Giovanna
AU - Borrego, Francisco
AU - Coligan, John E.
T1 - Endocytosis and Intracellular Trafficking of Human Natural Killer Cell Receptors.
JO - Traffic
JF - Traffic
Y1 - 2009/12//
VL - 10
IS - 12
M3 - Article
SP - 1735
EP - 1744
PB - Wiley-Blackwell
SN - 13989219
AB - Natural killer (NK) cells play a vital role in the defense against viral infections and tumor development. NK cell function is primarily regulated by the sum of signals from a broad array of activation and inhibitory receptors. Key to generating the input level of either activating or inhibitory signals is the maintenance of receptor expression levels on the cell surface. Although the mechanisms of endocytosis and trafficking for some cell surface receptors, such as transferrin receptor and certain immune receptors, are very well known, that is not the situation for receptors expressed by NK cells. Recent studies have uncovered that endocytosis and trafficking routes characteristic for specific activation and inhibitory receptors can regulate the functional responses of NK cells. In this review, we summarize the current knowledge of receptor endocytosis and trafficking, and integrate this with our current understanding of NK cell receptor trafficking. [ABSTRACT FROM AUTHOR]
AB - Copyright of Traffic is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - KILLER cells
KW - ENDOCYTOSIS
KW - CELL membranes
KW - CELL-mediated cytotoxicity
KW - VIRUS diseases
KW - TRANSFERRIN
KW - endocytosis
KW - intra-cellular trafficking
KW - NK cell receptors
N1 - Accession Number: 45110664; Masilamani, Madhan 1 Peruzzi, Giovanna 2 Borrego, Francisco 3 Coligan, John E. 2; Email Address: jcoligan@niaid.nih.gov; Affiliation: 1: Jaffe Food Allergy Institute, Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA. 2: Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, Room 205, 12441 Parklawn Drive, Rockville, MD 20852, USA. 3: Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.; Source Info: Dec2009, Vol. 10 Issue 12, p1735; Subject Term: KILLER cells; Subject Term: ENDOCYTOSIS; Subject Term: CELL membranes; Subject Term: CELL-mediated cytotoxicity; Subject Term: VIRUS diseases; Subject Term: TRANSFERRIN; Author-Supplied Keyword: endocytosis; Author-Supplied Keyword: intra-cellular trafficking; Author-Supplied Keyword: NK cell receptors; Number of Pages: 10p; Document Type: Article
L3 - 10.1111/j.1600-0854.2009.00973.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45110664&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105245760
T1 - Commercial drivers' health: a naturalistic study of body mass index, fatigue, and involvement in safety-critical events.
AU - Wiegand DM
AU - Hanowski RJ
AU - McDonald SE
Y1 - 2009/12//
N1 - Accession Number: 105245760. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. Special Interest: Emergency Care. NLM UID: 101144385.
KW - Accidents, Traffic
KW - Automobile Driving
KW - Body Mass Index
KW - Fatigue -- Epidemiology
KW - Motor Vehicles
KW - Obesity -- Complications
KW - Fatigue -- Etiology
KW - Health Status
KW - Human
KW - Odds Ratio
KW - Risk Factors
KW - Safety
KW - Videorecording
SP - 573
EP - 579
JO - Traffic Injury Prevention
JF - Traffic Injury Prevention
JA - TRAFFIC INJ PREV
VL - 10
IS - 6
CY - Philadelphia, Pennsylvania
PB - Taylor & Francis Ltd
SN - 1538-9588
AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. dwiegand@cdc.gov
U2 - PMID: 19916128.
DO - 10.1080/15389580903295277
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105245760&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gubernot, Diane M.
AU - Nakhasi, Hira L.
AU - Mied, Paul A.
AU - Asher, David M.
AU - Epstein, Jay S.
AU - Kumar, Sanjai
T1 - Transfusion-transmitted babesiosis in the United States: summary of a workshop.
JO - Transfusion
JF - Transfusion
Y1 - 2009/12//
VL - 49
IS - 12
M3 - Article
SP - 2759
EP - 2771
PB - Wiley-Blackwell
SN - 00411132
AB - Infections of humans with intraerythrocytic parasites of the genus Babesia can be locally prevalent in diverse regions of the United States. Transfusion of blood and blood products collected from donors infected with Babesia may result in a serious illness that can be fatal. In September 2008, the Food and Drug Administration organized a public workshop to discuss the various aspects of transfusion-transmitted babesiosis in the United States including the possible strategies to identify and defer blood donors who may have been infected with Babesia. Discussions were also held on the biology, pathogenesis, and epidemiology of Babesia species. In this article, we summarize the scientific presentations and panel discussions that took place during the workshop. [ABSTRACT FROM AUTHOR]
AB - Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - BLOOD transfusion
KW - BABESIOSIS
KW - COMMUNICABLE diseases -- Transmission
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 45537249; Gubernot, Diane M. 1 Nakhasi, Hira L. 1 Mied, Paul A. 1 Asher, David M. 1 Epstein, Jay S. 1 Kumar, Sanjai 1; Email Address: sanjai.kumar@fda.hhs.gov; Affiliation: 1: Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.; Source Info: Dec2009, Vol. 49 Issue 12, p2759; Subject Term: BLOOD transfusion; Subject Term: BABESIOSIS; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; Number of Pages: 13p; Illustrations: 1 Diagram, 2 Charts; Document Type: Article
L3 - 10.1111/j.1537-2995.2009.02429.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45537249&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105127267
T1 - Transfusion-transmitted babesiosis in the United States: summary of a workshop.
AU - Gubernot DM
AU - Nakhasi HL
AU - Mied PA
AU - Asher DM
AU - Epstein JS
AU - Kumar S
Y1 - 2009/12//
N1 - Accession Number: 105127267. Language: English. Entry Date: 20100402. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Allied Health; Biomedical; Peer Reviewed; USA. Special Interest: Laboratory Diagnosis. NLM UID: 0417360.
KW - Protozoa
KW - Tick-Borne Diseases -- Epidemiology
KW - Tick-Borne Diseases -- Prevention and Control
KW - Tick-Borne Diseases -- Transmission
KW - Blood Transfusion -- Adverse Effects
KW - Blood Transfusion -- Statistics and Numerical Data
KW - Prevalence
KW - Risk Factors
KW - United States
SP - 2759
EP - 2771
JO - Transfusion
JF - Transfusion
JA - TRANSFUSION
VL - 49
IS - 12
CY - Malden, Massachusetts
PB - Wiley-Blackwell
SN - 0041-1132
AD - From the Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland.
U2 - PMID: 19821952.
DO - 10.1111/j.1537-2995.2009.02429.x
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105127267&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105279823
T1 - Feelings of safety inside prison among male inmates with different victimization experiences.
AU - Wolff N
AU - Shi J
Y1 - 2009/12//
N1 - Accession Number: 105279823. Language: English. Entry Date: 20100226. Revision Date: 20150711. Publication Type: Journal Article; research. Commentary: Girardin B. Research briefs. (ON EDGE) Spring2010; 16 (1): 3p-3p. Journal Subset: Biomedical; USA. NLM UID: 8916436.
KW - Crime Victims -- Statistics and Numerical Data
KW - Prisoners -- Statistics and Numerical Data
KW - Correctional Facilities
KW - Safety
KW - Sexual Abuse
KW - Adult
KW - Aggression -- Psychosocial Factors
KW - Crime Victims -- Psychosocial Factors
KW - Human
KW - Interpersonal Relations
KW - Male
KW - Middle Age
KW - Prisoners -- Psychosocial Factors
KW - Questionnaires
KW - Risk Factors
KW - Sexual Abuse -- Psychosocial Factors
KW - United States
KW - Young Adult
SP - 800
EP - 816
JO - Violence & Victims
JF - Violence & Victims
JA - VIOLENCE VICTIMS
VL - 24
IS - 6
CY - New York, New York
PB - Springer Publishing Company, Inc.
SN - 0886-6708
AD - Center for Mental Health Services & Criminal Justice Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA. nwolff@ifh.rutgers.edu
U2 - PMID: 20055216.
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105279823&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 2009-24153-008
AN - 2009-24153-008
AU - Lucchini, Roberto G.
AU - Martin, Christopher J.
AU - Doney, Brent C.
T1 - From manganism to manganese-induced Parkinsonism: A conceptual model based on the evolution of exposure.
JF - NeuroMolecular Medicine
JO - NeuroMolecular Medicine
JA - Neuromolecular Med
Y1 - 2009/12//
VL - 11
IS - 4
SP - 311
EP - 321
CY - Germany
PB - Springer
SN - 1535-1084
SN - 1559-1174
AD - Doney, Brent C., Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, US, 26505
N1 - Accession Number: 2009-24153-008. PMID: 20012385 Partial author list: First Author & Affiliation: Lucchini, Roberto G.; Department of Experimental and Applied Medicine, Section of Occupational Health and Industrial Hygiene, University of Brescia, Brescia, Italy. Release Date: 20100215. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Mental Disorders due to General Medical Conditions; Metals; Parkinsonism. Classification: Neurological Disorders & Brain Damage (3297). Population: Human (10). Methodology: Literature Review. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2009. Publication History: First Posted Date: Dec 10, 2009; Accepted Date: Nov 19, 2009; First Submitted Date: Oct 2, 2009. Copyright Statement: US Government. 2009.
AB - Manganism is a distinct medical condition from Parkinson’s disease. Manganese exposure scenarios in the last century generally have changed from the acute, high-level exposure conditions responsible for the occurrence of manganism to chronic exposure to much lower levels. Such chronic exposures may progressively extend the site of manganese deposition and toxicity from the globus pallidus to the entire area of the basal ganglia, including the substantia nigra pars compacta involved in Parkinson’s disease. The mechanisms of manganese neurotoxicity from chronic exposure to very low levels are not well understood, but promising information is based on the concept of susceptibility that may place individuals exposed to manganese at a higher risk for developing Parkinsonian disturbances. These conditions include mutations of genes which play important pathogenetic roles in both Parkinsonism and in the regulation of manganese transport and metabolism. Liver function is also important in manganese-related neurotoxicity and sub-clinical impairment may increase the risk of Parkinsonism. The purpose and scope of this report are to explore the literature concerning manganese exposure and potential sub-clinical effects and biological pathways, impairment, and development of diseases such as Parkinsonism and manganism. Inhalation and ingestion of manganese will be the focus of this report. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - manganism
KW - manganese induced Parkinsonism
KW - manganese exposure
KW - medical condition
KW - 2009
KW - Mental Disorders due to General Medical Conditions
KW - Metals
KW - Parkinsonism
KW - 2009
DO - 10.1007/s12017-009-8108-8
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-24153-008&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-9723-0237
UR - bdoney@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-21655-002
AN - 2009-21655-002
AU - Aranaz-Andrés, Jesus M.
AU - Aibar-Remón, C.
AU - Vitaller-Burillo, J.
AU - Requena-Puche, J.
AU - Terol-García, E.
AU - Kelley, E.
AU - de Castro, M. T. Gea-Velazquez
T1 - Impact and preventability of adverse events in Spanish public hospitals: Results of the Spanish National Study of Adverse Events (ENEAS).
JF - International Journal for Quality in Health Care
JO - International Journal for Quality in Health Care
JA - Int J Qual Health Care
Y1 - 2009/12//
VL - 21
IS - 6
SP - 408
EP - 414
CY - United Kingdom
PB - Oxford University Press
SN - 1353-4505
SN - 1464-3677
AD - Aranaz-Andrés, Jesus M., Department of Public Health, Miguel Hernandez University, San Juan Campus, Carretera de Alicante a Valencia s/n, 03550, San Juan de Alicante, Spain
N1 - Accession Number: 2009-21655-002. PMID: 19841027 Partial author list: First Author & Affiliation: Aranaz-Andrés, Jesus M.; Department of Preventive Medicine, Teaching Hospital of Sant Joan d’Alacant, Miguel Hernandez University of Elche, Spain. Institutional Authors: The Eneas Work Group. Release Date: 20100125. Correction Date: 20130909. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health; Health Care Services; Hospitals; Prevention. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: Spain. Methodology: Empirical Study; Longitudinal Study; Retrospective Study; Quantitative Study. References Available: Y. Page Count: 7. Issue Publication Date: Dec, 2009. Publication History: First Posted Date: Oct 19, 2009; Accepted Date: Sep 23, 2009. Copyright Statement: All rights reserved. The Author. 2009.
AB - Objective: To determine the impact and preventability of adverse events (AEs) associated with health care in Spanish hospitals. Design: Retrospective cohort study. Setting: Twenty-four Spanish hospitals. Participants. Patients of any age with a clinical record indicating an inpatient stay of >24 h and a discharge between 4 and 10 June 2005 (n = 5908). Intervention: None. Main Outcome Measures: Percentage of AEs considered preventable. Results: We were able to identify 525 patients suffering AEs associated directly with medical care, who accumulated 655 AEs with 43% of these AEs considered preventable. Overall, 45% (295 AEs) were considered minor, 39% (255 AEs) moderate and 16% (105 AEs) severe. There were no significant differences in AE severity by hospital size, but AEs associated with surgical services were more likely to be severe than those associated with medical services. Some 31.4% of AEs resulted in a longer stay and 23.4% led to hospital admission. AEs associated with medical care caused 6.1 additional days per patient. Of the patients, 66.3% required additional procedures and 69.9% required additional treatments. Incidence of death in patients with AEs was 4.4% (CI 95%: 2.8-6.5). Age over 65 was associated with a higher incidence of preventable AEs. The highest percentages of preventable AEs were related to diagnosis (84.2%), to nosocomial infections (56.6%) and to care (56%). Conclusions: In Spanish hospitals, AEs associated with health care cause distress, disability, death, lengthen hospital stay and cause increased consumption of health-care resources. A relatively high percentage of AEs in Spain may be preventable with improvements in medical care. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - preventability
KW - Spanish public hospitals
KW - Spanish National Study of Adverse Events
KW - health care
KW - 2009
KW - Health
KW - Health Care Services
KW - Hospitals
KW - Prevention
KW - 2009
U1 - Sponsor: Miguel Hernandez University/Ministry of Health and Consumption. Other Details: ENEAS study. Recipients: No recipient indicated
DO - 10.1093/intqhc/mzp047
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-21655-002&site=ehost-live&scope=site
UR - aranaz_jes@gva.es
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-21935-001
AN - 2009-21935-001
AU - Moore, Susan M.
AU - Porter, William L.
AU - Dempsey, Patrick G.
T1 - Fall from equipment injuries in U.S. mining: Identification of specific research areas for future investigation.
JF - Journal of Safety Research
JO - Journal of Safety Research
JA - J Safety Res
Y1 - 2009/12//
VL - 40
IS - 6
SP - 455
EP - 460
CY - Netherlands
PB - Elsevier Science
SN - 0022-4375
AD - Moore, Susan M., 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA, US, 15236
N1 - Accession Number: 2009-21935-001. PMID: 19945559 Partial author list: First Author & Affiliation: Moore, Susan M.; National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, US. Release Date: 20091116. Correction Date: 20100125. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Business and Industrial Personnel; Falls; Injuries; Occupational Safety. Minor Descriptor: Business Organizations. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300); Young Adulthood (18-29 yrs) (320); Thirties (30-39 yrs) (340); Middle Age (40-64 yrs) (360); Aged (65 yrs & older) (380). Methodology: Empirical Study; Qualitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2009. Publication History: First Posted Date: Oct 30, 2009. Copyright Statement: All rights reserved. National Safety Council and Elsevier Ltd
AB - Introduction: The objective of this study was to evaluate the circumstances leading to fall from equipment injuries in the mining industry. Method: The 2006 and 2007 Mine Safety and Health Administration annual injury databases were utilized for this study whereby the injury narrative, nature of injury, body part injured, mine type, age at injury, and days lost were evaluated for each injury. Results: The majority of injuries occurred at surface mining facilities (∼60%) with fractures and sprains/strains being the most common injuries occurring to the major joints of the body. Nearly 50% of injuries occurred during ingress/egress, predominately during egress, and approximately 25% of injuries occurred during maintenance tasks. The majority of injuries occurred in relation to large trucks, wheel loaders, dozers, and conveyors/belts. The severity of injury was independent of age and the median days lost was seven days; however, there was a large range in severity. Impact on industry: From the data obtained in this study, several different research areas have been identified for future work, which include balance and stability control when descending ladders and equipment design for maintenance tasks. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - falls circumstances
KW - equipment injuries
KW - US Mining companies
KW - mining industry
KW - future research
KW - risk factors
KW - 2009
KW - Business and Industrial Personnel
KW - Falls
KW - Injuries
KW - Occupational Safety
KW - Business Organizations
KW - 2009
U1 - Sponsor: National Institute for Occupational Safety and Health. Recipients: No recipient indicated
DO - 10.1016/j.jsr.2009.10.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-21935-001&site=ehost-live&scope=site
UR - Pdempsey@cdc.gov
UR - WLPorter@cdc.gov
UR - SMMoore@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-00260-005
AN - 2010-00260-005
AU - Boer, Frits
AU - Smit, Cees
AU - Morren, Mattijn
AU - Roorda, Jan
AU - Yzermans, Joris
T1 - Impact of a technological disaster on young children: A five-year postdisaster multiinformant study.
T3 - Innovations in trauma research methods
JF - Journal of Traumatic Stress
JO - Journal of Traumatic Stress
JA - J Trauma Stress
Y1 - 2009/12//
VL - 22
IS - 6
SP - 516
EP - 524
CY - US
PB - John Wiley & Sons
SN - 0894-9867
SN - 1573-6598
AD - Boer, Frits, AMC de Bascule, CA Psychiatry, Meibergdreef 5, 1105 AZ, Amsterdam, Netherlands
N1 - Accession Number: 2010-00260-005. PMID: 19824065 Partial author list: First Author & Affiliation: Boer, Frits; Academic Medical Centre, Department of Child and Adolescent Psychiatry/de Bascule, Amsterdam, Netherlands. Release Date: 20100308. Correction Date: 20120827. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Print. Document Type: Journal Article. Language: English. Major Descriptor: Anxiety; Disasters; Mental Health; Posttraumatic Stress Disorder; Psychiatric Symptoms. Minor Descriptor: Technology. Classification: Psychological & Physical Disorders (3200); Environmental Issues & Attitudes (4070). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Childhood (birth-12 yrs) (100); School Age (6-12 yrs) (180). Tests & Measures: Short Depression Inventory for Children; Children's Somatisation Inventory; Children's Impact of Events Scale; Strengths and Difficulties Questionnaire DOI: 10.1037/t00540-000; Screen for Child Anxiety Related Emotional Disorders DOI: 10.1037/t03542-000. Methodology: Empirical Study; Followup Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2009. Copyright Statement: International Society for Traumatic Stress Studies. 2009.
AB - Children exposed to a technological disaster during an understudied part of the lifespan, preschool age and early middle childhood, were assessed in a 5-year follow-up regarding mental health problems, anxiety disorder symptoms, depressive symptoms, physical symptoms, and posttraumatic stress symptoms. Exposed children and their parents (n = 264) reported significantly more problems than controls (n = 515). The differences were greater for conduct problems (including hyperactivity) and physical symptoms, than for anxiety and depression. The long-term effects of a technological disaster on children of preschool age at exposure appear to differ from those in children, who were victimized at a later age. This may reflect interference with completion of specific developmental tasks. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - fireworks disaster
KW - young children
KW - mental health problems
KW - anxiety disorder symptoms
KW - depressive symptoms
KW - physical symptoms
KW - posttraumatic stress symptoms
KW - 2009
KW - Anxiety
KW - Disasters
KW - Mental Health
KW - Posttraumatic Stress Disorder
KW - Psychiatric Symptoms
KW - Technology
KW - 2009
U1 - Sponsor: Netherlands Ministry of Public Health, Welfare, and Sports, Netherlands. Recipients: No recipient indicated
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-00260-005&site=ehost-live&scope=site
UR - f.boer@amc.uva.nl
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-16602-006
AN - 2009-16602-006
AU - Teisl, Mario F.
AU - Fein, Sara B.
AU - Levy, Alan S.
T1 - Information effects on consumer attitudes toward three food technologies: Organic production, biotechnology, and irradiation.
JF - Food Quality and Preference
JO - Food Quality and Preference
JA - Food Qual Prefer
Y1 - 2009/12//
VL - 20
IS - 8
SP - 586
EP - 596
CY - Netherlands
PB - Elsevier Science
SN - 0950-3293
AD - Teisl, Mario F., School of Economics, University of Maine, 5782 Winslow Hall, Orono, ME, US, 04469
N1 - Accession Number: 2009-16602-006. Partial author list: First Author & Affiliation: Teisl, Mario F.; School of Economics, University of Maine, Orono, ME, US. Release Date: 20090928. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Biotechnology; Consumer Attitudes; Food; Radiation. Minor Descriptor: Technology. Classification: Consumer Attitudes & Behavior (3920). Population: Human (10). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 11. Issue Publication Date: Dec, 2009. Publication History: Accepted Date: Jul 8, 2009; Revised Date: Jul 8, 2009; First Submitted Date: Jan 15, 2008. Copyright Statement: Elsevier Ltd. 2009.
AB - It is important to understand how information supplied to consumers affects their attitudes about food technologies because these attitudes can impact market behavior. As technologies are actively promoted and cross-promoted, the relation between one’s knowledge of, and attitude toward, a technology may well depend on the source of one’s information. We examine the relation between knowledge and attitudes toward food technologies and find that greater self-rated knowledge of each technology is associated with positive attitudes about that technology. We also find strong negative cross-informational effects; increased knowledge of one technology leads to more negative attitudes of other technologies. This effect may be due to negative information being provided by opponents of specific technologies. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - consumer attitudes
KW - food technologies
KW - organic production
KW - biotechnology
KW - irradiation
KW - 2009
KW - Biotechnology
KW - Consumer Attitudes
KW - Food
KW - Radiation
KW - Technology
KW - 2009
DO - 10.1016/j.foodqual.2009.07.001
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-16602-006&site=ehost-live&scope=site
UR -
UR - ORCID: 0000-0002-2021-9208
UR - teisl@maine.edu
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-05808-014
AN - 2010-05808-014
AU - Asfaw, Abay
AU - Pana-Cryan, Regina
T1 - The impact of self-insuring for workers’ compensation on the incidence rates of worker injury and illness.
JF - Journal of Occupational and Environmental Medicine
JO - Journal of Occupational and Environmental Medicine
JA - J Occup Environ Med
Y1 - 2009/12//
VL - 51
IS - 12
SP - 1466
EP - 1473
CY - US
PB - Lippincott Williams & Wilkins
SN - 1076-2752
SN - 1536-5948
AD - Asfaw, Abay, Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Office of the Director, Suite 9200, Patriots Plaza, 395 E Street, SW, Washington, DC, US, 20201
N1 - Accession Number: 2010-05808-014. PMID: 19952789 Partial author list: First Author & Affiliation: Asfaw, Abay; Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Office of the Director, Washington, DC, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Employee Health Insurance; Injuries; Personnel; Work Related Illnesses; Workers' Compensation Insurance. Classification: Working Conditions & Industrial Safety (3670). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 8. Issue Publication Date: Dec, 2009. Copyright Statement: American College of Occupational and Environmental Medicine. 2009.
AB - Objective: There is moderate evidence that workers in experience-rated firms sustain less injuries when compared with workers in firms that are not experience rated. This study aims to provide more insight on this issue. Methods: Panel data from the Bureau of Labor Statistics and National Academy of Social Insurance between 1999 and 2006 were used. A theoretical framework was developed, and a fixed effects vector decomposition model was estimated. Results: Self-insuring was positively associated with relatively low worker injury and illness incidence rates when compared with insuring (including experience rating and manually rating). After controlling for workforce characteristics, industrial composition, firm size, and state-specific laws, states with an above the median percentage of self-insured firms had incidence rates that were lower than rates in states with a below the median percentage of self-insured firms. Conclusion: A higher degree of experience rating seems to better align the economic incentive to invest in prevention and the intended outcome of reducing worker injury and illness. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - self insuring
KW - workers compensation
KW - worker injury
KW - worker illness
KW - 2009
KW - Employee Health Insurance
KW - Injuries
KW - Personnel
KW - Work Related Illnesses
KW - Workers' Compensation Insurance
KW - 2009
DO - 10.1097/JOM.0b013e3181c16373
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-05808-014&site=ehost-live&scope=site
UR - hqp0@cdc.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-23903-002
AN - 2009-23903-002
AU - Rosenbach, Margo L.
AU - Lake, Timothy K.
AU - Williams, Susan R.
AU - Buck, Jeffrey A.
T1 - Implementation of mental health parity: Lessons from California.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/12//
VL - 60
IS - 12
SP - 1589
EP - 1594
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
AD - Rosenbach, Margo L., Mathematica Policy Research, 955 Massachusetts Ave., Suite 801, Cambridge, MA, US, 02139
N1 - Accession Number: 2009-23903-002. PMID: 19952147 Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Rosenbach, Margo L.; Mathematica Policy Research, Cambridge, MA, US. Release Date: 20100301. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Laws; Mental Health Parity; Health Care Policy; Health Care Reform. Minor Descriptor: Consumer Attitudes; Life Experiences. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Adulthood (18 yrs & older) (300). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2009.
AB - Objective: This article reports the experiences of health plans, providers, and consumers with California’s mental health parity law and discusses implications for implementation of the 2008 federal parity law. Methods: This study used a multimodal data collection approach to assess the first five years of California’s parity implementation (from 2000 to 2005). Telephone interviews were conducted with 68 state-level stakeholders, and in-person interviews were conducted with 77 community- based stakeholders. Six focus groups included 52 providers, and six included 32 consumers. A semistructured interview protocol was used. Interview notes and transcripts were coded to facilitate analysis. Results: Health plans eliminated differential benefit limits and cost-sharing requirements for certain mental disorders to comply with the law, and they used managed care to control costs. In response to concerns about access to and quality of care, the state expanded oversight of health plans, issuing access-to-care regulations and conducting focused studies. California’s parity law applied to a limited list of psychiatric diagnoses. Health plan executives said they spent considerable resources clarifying which diagnoses were covered at parity levels and concluded that the limited diagnosis list was unnecessary with managed care. Providers indicated that the diagnosis list had unintended consequences, including incentives to assign a more severe diagnosis that would be covered at parity levels, rather than a less severe diagnosis that would not be covered at such levels. The lack of consumer knowledge about parity was widely acknowledged, and consumers in the focus groups requested additional information about parity. Conclusions: Experiences in California suggest that implementation of the 2008 federal parity law should include monitoring health plan performance related to access and quality, in addition to monitoring coverage and costs; examining the breadth of diagnoses covered by health plans; and mounting a campaign to educate consumers about their insurance benefits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - implementation
KW - mental health parity
KW - federal parity law
KW - lessons
KW - California
KW - providers experiences
KW - consumers experiences
KW - health plans
KW - 2009
KW - Laws
KW - Mental Health Parity
KW - Health Care Policy
KW - Health Care Reform
KW - Consumer Attitudes
KW - Life Experiences
KW - 2009
U1 - Sponsor: Substance Abuse and Mental Health Services Administration. Grant: 282-92-0021(27). Recipients: No recipient indicated
DO - 10.1176/appi.ps.60.12.1589
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-23903-002&site=ehost-live&scope=site
UR - mrosenbach@mathematica-mpr.com
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2009-23903-033
AN - 2009-23903-033
AU - Crandell, Allan E.
T1 - Review of The house of widows: An oral history.
JF - Psychiatric Services
JO - Psychiatric Services
JA - Psychiatr Serv
Y1 - 2009/12//
VL - 60
IS - 12
SP - 1697
EP - 1697
CY - US
PB - American Psychiatric Assn
SN - 1075-2730
SN - 1557-9700
N1 - Accession Number: 2009-23903-033. Other Journal Title: Hospital & Community Psychiatry. Partial author list: First Author & Affiliation: Crandell, Allan E.; Iina’ Counseling Services, Indian Health Service, Northern Navajo Medical Center, Shiprock, NM, US. Release Date: 20100301. Correction Date: 20160428. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Review-Book. Language: English. Major Descriptor: Suicide; Widows; Interpersonal Relationships. Classification: Health & Mental Health Treatment & Prevention (3300). Population: Human (10). Reviewed Item: Melnyczuk, Askold. The house of widows: An oral history=St. Paul, Minnesota, Graywolf Press, 253 pages, $16; 2008. Page Count: 1. Issue Publication Date: Dec, 2009.
AB - Reviews the book The House of Widows: An Oral History by Askold Melnyczuk (2008). In his third novel, author Askold Melnyczuk presents us with the primal themes of love and death as closely entwined as two strands of literary DNA. On another level the reader is invited to consider sex and intimacy cloaked in the 'syntax of deceit,' as the tale is freighted with a cast of characters from New England to Kiev who are often in surprising relationships with one another, some of them involved in the international sex trade. Woven darkly throughout the novel, the central question remains: how to account for the suicide of a loved one, particularly of one’s father. We often encounter patients who survive as relatives of those who have committed suicide, and this is a novelistic portrayal of the search for meaning and attempted individuation within the penumbra of a completed suicide. Clinicians will find much to ponder in this novel with its several interwoven themes of fraternal betrayal, paternal suicide, and the search for sel (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - widows
KW - interpersonal relationships
KW - suicide
KW - 2009
KW - Suicide
KW - Widows
KW - Interpersonal Relationships
KW - 2009
U2 - Melnyczuk, Askold. (2008); The house of widows: An oral history; St. Paul, Minnesota, Graywolf Press, 253 pages, $16
DO - 10.1176/appi.ps.60.12.1697
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-23903-033&site=ehost-live&scope=site
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-04503-001
AN - 2010-04503-001
AU - Kogan, Michael D.
AU - Strickland, Bonnie B.
AU - Newacheck, Paul W.
T1 - Building systems of care: Findings from the National Survey of Children With Special Health Care Needs.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/12//
VL - 124
IS - 6, Suppl 4
SP - S333
EP - S336
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Kogan, Michael D., Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2010-04503-001. Partial author list: First Author & Affiliation: Kogan, Michael D.; US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Rockville, MD, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Service Needs; Pediatrics; Special Needs. Minor Descriptor: Childhood Development; Mental Health Services. Classification: Health & Mental Health Services (3370). Population: Human (10). Age Group: Childhood (birth-12 yrs) (100). References Available: Y. Page Count: 4. Issue Publication Date: Dec, 2009. Publication History: Accepted Date: Aug 3, 2009. Copyright Statement: The American Academy of Pediatrics. 2009.
AB - Approximately 1 of every 7 children younger than 18 years in the United States, or ∼10.2 million children, can be classified as having special health care needs. Until the 2001 National Survey of Children With Special Health Care Needs (NS-CSHCN), little was known about this population. The 2001 NS-CSHCN was the first large-scale study devoted to assessing the health and health care experiences of this population. This study was also one of the first surveys of children in which it was possible to derive state-level estimates. This supplement to Pediatrics is dedicated to findings from the second national study of this population: the 2005–2006 NS-CSHCN. The 15 articles in this supplemental issue of Pediatrics were selected from among numerous worthy proposals that were submitted after a national solicitation. The call for proposals was disseminated through professional meetings and data-user Listservs. More than 60 proposals for articles were received and reviewed by the coeditors. The proposals were reviewed for originality, feasibility, variety, geographic diversity, use of innovative methods, and program, policy, and clinical relevance. It is striking how many authors took advantage of the unique state- and national-level design to compare states or regions. The sophistication of the methods used is also noteworthy: More than half of the authors of the articles in this supplemental issue used multilevel modeling to merge the individual-level data from the survey with contextual-level data, such as state parity laws for mental health care or Part C eligibility policy for early intervention programs. Because the data were obtained from a cross-sectional survey based on parent interviews, there are certain limitations to the analyses presented in this supplement. Notably, families without telephones are underrepresented, although survey weights were adjusted accordingly. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - National Survey of Children With Special Health Care Needs
KW - mental health services
KW - health care services
KW - pediatrics
KW - 2009
KW - Health Care Services
KW - Health Service Needs
KW - Pediatrics
KW - Special Needs
KW - Childhood Development
KW - Mental Health Services
KW - 2009
DO - 10.1542/peds.2009-1255B
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-04503-001&site=ehost-live&scope=site
UR - mkogan@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-04503-004
AN - 2010-04503-004
AU - Singh, Gopal K.
AU - Strickland, Bonnie B.
AU - Ghandour, Reem M.
AU - van Dyck, Peter C.
T1 - Geographic disparities in access to the medical home among US CSHCN.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/12//
VL - 124
IS - 6, Suppl 4
SP - S352
EP - S360
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Singh, Gopal K., US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, US, 20857
N1 - Accession Number: 2010-04503-004. Partial author list: First Author & Affiliation: Singh, Gopal K.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Care Utilization; Health Service Needs; Special Needs; Health Disparities. Minor Descriptor: Adolescent Development; Childhood Development; Pediatrics; Regional Differences. Classification: Health & Mental Health Services (3370). Population: Human (10); Male (30); Female (40). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 9. Issue Publication Date: Dec, 2009. Publication History: Accepted Date: Aug 3, 2009. Copyright Statement: The American Academy of Pediatrics. 2009.
AB - Objective: In this study we examined geographic disparities in medical home access among US children with special health care needs (CSHCN) aged 0 to 17 years. Methods: The 2005–2006 National Survey of Children With Special Health Care Needs was used to estimate prevalence and odds of not having a medical home and 5 component outcomes according to state. Logistic regression was used to examine individual-level and state-level determinants of access. Results: Medical home access varied substantially across geographic areas. CSHCN in Alaska, Arizona, Washington, DC, Florida, Illinois, Massachusetts, New Jersey, Nevada, and Virginia had at least 50% higher adjusted odds of not having a medical home than CSHCN in Iowa. The adjusted prevalence of CSHCN lacking a medical home varied from a low of 46% in Iowa and Ohio to a high of 59% in Alaska and 61% in New Jersey. CSHCN in several western and southwestern states experienced greater problems with access to a personal doctor/nurse, a usual source of care, specialty care referrals, care coordination, and family-centered care. Adjustment for age, gender, race/ethnicity, household socioeconomic status, language use, insurance coverage, and functional limitation reduced state disparities in access. CSHCN in states with higher immigrant and non–English-speaking populations had significantly lower medical home access. Increases in state health care expenditure and infrastructure and Medicaid/State Children's Health Insurance Program eligibility were associated with increased access to a personal doctor/nurse. Conclusions: Although individual-level sociodemographic and state-level health policy variables are important predictors of access, substantial geographic disparities remain, with CSHCN in several western and northeastern states at high risk of not having a medical home. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - medical homes
KW - US
KW - children with special health care needs
KW - geographic disparities
KW - health care services
KW - health care utilization
KW - 2009
KW - Health Care Services
KW - Health Care Utilization
KW - Health Service Needs
KW - Special Needs
KW - Health Disparities
KW - Adolescent Development
KW - Childhood Development
KW - Pediatrics
KW - Regional Differences
KW - 2009
DO - 10.1542/peds.2009-1255E
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-04503-004&site=ehost-live&scope=site
UR - gsingh@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 2010-04503-011
AN - 2010-04503-011
AU - Yu, Stella M.
AU - Singh, Gopal K.
T1 - Household language use and health care access, unmet need, and family impact among CSHCN.
JF - Pediatrics
JO - Pediatrics
JA - Pediatrics
Y1 - 2009/12//
VL - 124
IS - 6, Suppl 4
SP - S414
EP - S419
CY - US
PB - American Academy of Pediatrics
SN - 0031-4005
SN - 1098-4275
AD - Yu, Stella M., US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Rockville, MD, US, 20857
N1 - Accession Number: 2010-04503-011. Partial author list: First Author & Affiliation: Yu, Stella M.; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, US. Release Date: 20101018. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Health Care Services; Health Care Utilization; Health Service Needs; Language; Special Needs. Minor Descriptor: Childhood Development; Family; Pediatrics. Classification: Health & Mental Health Services (3370). Population: Human (10). Location: US. Age Group: Childhood (birth-12 yrs) (100); Infancy (2-23 mo) (140); Preschool Age (2-5 yrs) (160); School Age (6-12 yrs) (180); Adolescence (13-17 yrs) (200). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 6. Issue Publication Date: Dec, 2009. Publication History: Accepted Date: Aug 3, 2009. Copyright Statement: The American Academy of Pediatrics. 2009.
AB - Objectives: We examined the association of household language use and access to care among children with special health care needs (CSHCN). From this study we describe the demographics of children and the prevalence of selected access characteristics according to their primary household language and examine the independent effects of household language on health care access, unmet needs, and family impact while controlling for confounding variables. Methods: Data from the 2005–2006 National Survey of Children With Special Health Care Needs, a nationally representative telephone survey of 40723 CSHCN, were analyzed. Bivariate and multivariable analyses were used to examine disparities and estimate adjusted odds ratios of health care access, satisfaction, and family-impact measures for CSHCN from non–English-primary-language (NEPL) versus English-primary-language (EPL) households. Results: Nearly 14% of all US children live in NEPL households. NEPL CSHCN were significantly more likely to be Hispanic or other race, be poor, have less educated parents, and reside in metropolitan areas and larger households and yet were less likely to be on cash assistance from welfare. Logistic regression showed that NEPL CSHCN were twice as likely to lack access to a medical home, a usual source of care, and family-centered care. They were 4 times as likely to lack health insurance, and their family members were also more likely to lack adequate insurance. Family members of NEPL children were almost twice as likely to have to stop employment as a result of their child's condition. Conclusions: Although limited by program eligibility contingent on immigrant status and state policies, increased referrals to programs such as the State Children's Health Insurance Program and Medicaid can improve access while utilization can be improved by the availability of interpreters, community health workers, linguistically concordant providers, and outreach education efforts of NEPL parents. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
KW - household language use
KW - health care access
KW - family impact
KW - children with special health care needs
KW - health care services
KW - pediatrics
KW - unmet need
KW - 2009
KW - Health Care Services
KW - Health Care Utilization
KW - Health Service Needs
KW - Language
KW - Special Needs
KW - Childhood Development
KW - Family
KW - Pediatrics
KW - 2009
DO - 10.1542/peds.2009-1255M
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2010-04503-011&site=ehost-live&scope=site
UR - syu@hrsa.gov
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
ID - 105255159
T1 - American Indians and physical activity expanding the picture improves the view.
AU - Acton KJ
AU - Bullock A
Y1 - 2009/12/02/Dec2009 Supplement 1
N1 - Accession Number: 105255159. Language: English. Entry Date: 20100730. Revision Date: 20150711. Publication Type: Journal Article; commentary. Supplement Title: Dec2009 Supplement 1. Original Study: Duncan GE, Goldberg J, Buchwald D, Wen Y, Henderson JA, Duncan Glen E, et al. Epidemiology of physical activity in American Indians in the Education and Research Towards Health cohort. (AM J PREV MED) Dec2009 Supplement 1; 37 (6): 488-494; Storti KL, Arena VC, Barmada MM, Bunker CH, Hanson RL, Laston SL, et al. Physical activity levels in American-Indian adults: the Strong Heart Family Study. (AM J PREV MED) Dec2009 Supplement 1; 37 (6): 481-487. Journal Subset: Biomedical; Health Promotion/Education; USA. NLM UID: 8704773.
KW - Exercise
KW - Native Americans
KW - Health Promotion
KW - United States
SP - 572
EP - 573
JO - American Journal of Preventive Medicine
JF - American Journal of Preventive Medicine
JA - AM J PREV MED
VL - 37
IS - 6
CY - New York, New York
PB - Elsevier Science
SN - 0749-3797
AD - Division of Diabetes Treatment and Prevention, Indian Health Service, Albuquerque, New Mexico
U2 - PMID: 19944927.
DO - 10.1016/j.amepre.2009.09.029
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105255159&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
ID - 105279776
T1 - Implications of the Emergency Medical Treatment and Labor Act (EMTALA) during public health emergencies and on alternate sites of care.
AU - Roszak AR
AU - Jensen FR
AU - Wild RE
AU - Yeskey K
AU - Handrigan MT
Y1 - 2009/12/02/2009 Dec Suppl 2
N1 - Accession Number: 105279776. Language: English. Entry Date: 20100326. Revision Date: 20150711. Publication Type: Journal Article. Supplement Title: 2009 Dec Suppl 2. Journal Subset: Biomedical; Public Health; USA. Special Interest: Public Health. NLM UID: 101297401.
KW - Disaster Planning -- Legislation and Jurisprudence
KW - Emergencies
KW - Emergency Medical Services -- Legislation and Jurisprudence
KW - Health Facility Administration -- Legislation and Jurisprudence
KW - Public Health -- Legislation and Jurisprudence
KW - Disaster Planning
KW - Emergency Medical Services -- Administration
KW - Health Resource Allocation -- Legislation and Jurisprudence
KW - Medicare -- Legislation and Jurisprudence
KW - Triage -- Legislation and Jurisprudence
KW - United States
SP - S172
EP - 5
JO - Disaster Medicine & Public Health Preparedness
JF - Disaster Medicine & Public Health Preparedness
JA - DISASTER MED PUBLIC HEALTH PREPAREDNESS
VL - 3
PB - Cambridge University Press
SN - 1935-7893
AD - US Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Senior Public Health Advisor, Emergency CareCoordination Center, Switzer Bldg Room 5217, 200 Independence Ave SW, Washington, DC 20201, USA. andrew.roszak@hhs.gov
U2 - PMID: 19952887.
DO - 10.1097/DMP.0b013e3181c6b664
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105279776&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Trumbo, Paula
AU - Shimakawa, Tomoko
T1 - U.S. Food and Drug Administration on modernization of the Nutrition and Supplements Facts labels
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2009/12/02/Dec2009 Supplement
VL - 22
M3 - Article
SP - S13
EP - S18
SN - 08891575
AB - Abstract: The U.S. Food and Drug Administration (FDA) issued an Advance Notice of Proposed Rulemaking (ANPRM) for obtaining public comments on modernizing the Nutrition and Supplements Facts label. Public comments to specific questions asked in the ANPRM will be considered by FDA for future rulemaking. There are numerous issues that FDA will consider during the rulemaking process, such as determining (1) which Dietary Reference Intakes (DRIs) to use for setting the Daily Values (DVs), (2) the approach for setting a single nutrient DV for adults and children over the age of 4 years, (3) which vitamins and minerals are of public health concern in the United States and therefore required to be declared in the Nutrition Facts label, (4) the definition of certain nutrients, such as total carbohydrate and fiber, (5) the labeling of trans fat, and (6) the use of International Units (IUs) for providing the amount of a vitamin. After reviewing the public comments, as well as any other new relevant information, FDA will publish a proposed rule in the Federal Register that provides the agency''s proposed decisions for modernizing the Nutrition and Supplements Facts label. Publication of a final rule, along with the Code of Federal Regulations, will set forth the new regulatory requirements for the Nutrition and Supplements Facts labels. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - DIETARY supplements -- Law & legislation
KW - FOOD -- Composition
KW - FOOD law & legislation
KW - FOOD labeling
KW - PUBLIC opinion
KW - FEDERAL regulation
KW - TRANS fatty acids
KW - UNITED States
KW - Daily Value
KW - Food composition
KW - Food data management
KW - Food labeling
KW - Nutrition Facts label
KW - Supplements Facts label
KW - United States food legislation
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 45578802; Trumbo, Paula; Email Address: Paula.Trumbo@FDA.HHS.gov Shimakawa, Tomoko 1; Affiliation: 1: US Food and Drug Administration, 5100 Paint Branch Parkway, HFS 830, College Park, MD 20740, United States; Source Info: Dec2009 Supplement, Vol. 22, pS13; Subject Term: DIETARY supplements -- Law & legislation; Subject Term: FOOD -- Composition; Subject Term: FOOD law & legislation; Subject Term: FOOD labeling; Subject Term: PUBLIC opinion; Subject Term: FEDERAL regulation; Subject Term: TRANS fatty acids; Subject Term: UNITED States; Author-Supplied Keyword: Daily Value; Author-Supplied Keyword: Food composition; Author-Supplied Keyword: Food data management; Author-Supplied Keyword: Food labeling; Author-Supplied Keyword: Nutrition Facts label; Author-Supplied Keyword: Supplements Facts label; Author-Supplied Keyword: United States food legislation; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 446191 Food (Health) Supplement Stores; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2009.01.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45578802&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - McCabe-Sellers, Beverly J.
AU - Chenard, Catherine Ann
AU - Lovera, Dalia
AU - Champagne, Catherine M.
AU - Bogle, Margaret L.
AU - Kaput, Jim
T1 - Readiness of food composition databases and food component analysis systems for nutrigenomics
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2009/12/02/Dec2009 Supplement
VL - 22
M3 - Article
SP - S57
EP - S62
SN - 08891575
AB - Abstract: The two-fold purpose of this paper is to examine the adequacy of food composition databases and dietary assessment techniques to meet the needs of nutritional genomic research and to explore the challenges and opportunities presented by the emerging field of nutrigenomics to future development of food composition databases and food composition analysis systems. A review of published literature and the Internet for organizations and their ongoing dialogues were used to explore how current food composition databases and nutritional assessment methodology could be made more useful in nutrigenomics research. An outline of current projects and potential approaches to develop more reliable and cost-effective methods for the study of nutrigenomics in diverse populations is presented. Many issues related to these dietary and database methodologies need to be addressed and overcome if nutrigenomics is to reach its potential for promoting optimal health through better individualization of diet and physical activity recommendations. To meet the complex research and clinical challenges of individualizing nutrition and health care, a network of diverse health care professionals and scientists is needed to move the world toward optimal health practices. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Composition
KW - DATABASES
KW - FOOD -- Analysis
KW - NUTRITION research
KW - GENOMICS
KW - COST effectiveness
KW - PHYSICAL activity
KW - NUTRITION surveys
KW - Diet
KW - Dietetics
KW - Food composition
KW - Food composition databases
KW - Nutrigenomics
KW - Nutrition assessment
KW - Nutrition surveys
N1 - Accession Number: 45578810; McCabe-Sellers, Beverly J. 1; Email Address: bev.mccabe-sellers@ars.usda.gov Chenard, Catherine Ann 2 Lovera, Dalia 1 Champagne, Catherine M. 3 Bogle, Margaret L. 1 Kaput, Jim 4; Affiliation: 1: USDA, Agricultural Research Service, Delta Obesity Prevention Research Unit, 900 S. Shackleford Road, Suite 509, Little Rock, AR 72211, USA 2: Institute for Clinical and Translational Science, University of Iowa, 200 Hawkins Drive, 157 Medical Research Facility, Iowa City, IA 52242-1183, USA 3: Pennington Biological Research Center, Baton Rouge, LA, 6400 Perkins Road, Baton Rouge, LA 70808, USA 4: Division of Personalized Nutrition and Medicine FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; Source Info: Dec2009 Supplement, Vol. 22, pS57; Subject Term: FOOD -- Composition; Subject Term: DATABASES; Subject Term: FOOD -- Analysis; Subject Term: NUTRITION research; Subject Term: GENOMICS; Subject Term: COST effectiveness; Subject Term: PHYSICAL activity; Subject Term: NUTRITION surveys; Author-Supplied Keyword: Diet; Author-Supplied Keyword: Dietetics; Author-Supplied Keyword: Food composition; Author-Supplied Keyword: Food composition databases; Author-Supplied Keyword: Nutrigenomics; Author-Supplied Keyword: Nutrition assessment; Author-Supplied Keyword: Nutrition surveys; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2009.02.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45578810&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brandt, Mary
AU - Moss, Julie
AU - Ferguson, Martine
T1 - The 2006–2007 Food Label and Package Survey (FLAPS): Nutrition labeling, trans fat labeling
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2009/12/02/Dec2009 Supplement
VL - 22
M3 - Article
SP - S74
EP - S77
SN - 08891575
AB - Abstract: Since the 1970s, the Center for Food Safety and Applied Nutrition at the United States (US) Food and Drug Administration (FDA) has studied product labels from the US food supply through the Food Label and Package Survey (FLAPS). The sampling frame for the latest survey, FLAPS 2006–2007, was the ACNielsen Strategic Planner food sales database. As the newest addition to the Nutrition Facts label, this latest FLAPS included trans fat and was utilized to characterize the prevalence of foods reporting trans fat information. For this survey, FDA used a new probability-based sample design to draw a list of food products. Products were purchased from retail stores across the US, and label information was recorded to create the FLAPS 2006–2007 database. Results of initial data analyses show that an estimated 96.3% of FDA-regulated processed, packaged foods have nutrition labeling, with an additional 3.7% exempt from mandatory nutrition labeling requirements. FLAPS data show that 12% of products provide a nutrient content claim about the amount of trans fat on the principal display panel, with over 75% displaying “0g trans fat.” FDA will continue to analyze FLAPS data as a tracking mechanism to monitor the market response to food label regulations and to support policy, regulatory, economic, and food safety decisions. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD labeling
KW - FOOD -- Packaging
KW - TRANS fatty acids
KW - FOOD -- Composition
KW - DATABASES
KW - FOOD supply
KW - FOOD industry
KW - UNITED States
KW - Data compilation
KW - Food composition
KW - Food data management
KW - Food Label and Package Survey
KW - Nutrition labeling
KW - Nutrition labeling databases
KW - Trans fat
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 45578813; Brandt, Mary; Email Address: mary.brandt@fda.hhs.gov Moss, Julie 1 Ferguson, Martine 1; Affiliation: 1: Office of Nutrition, Labeling and Dietary Supplements (HFS-830), Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA; Source Info: Dec2009 Supplement, Vol. 22, pS74; Subject Term: FOOD labeling; Subject Term: FOOD -- Packaging; Subject Term: TRANS fatty acids; Subject Term: FOOD -- Composition; Subject Term: DATABASES; Subject Term: FOOD supply; Subject Term: FOOD industry; Subject Term: UNITED States; Author-Supplied Keyword: Data compilation; Author-Supplied Keyword: Food composition; Author-Supplied Keyword: Food data management; Author-Supplied Keyword: Food Label and Package Survey; Author-Supplied Keyword: Nutrition labeling; Author-Supplied Keyword: Nutrition labeling databases; Author-Supplied Keyword: Trans fat; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 561910 Packaging and Labeling Services; NAICS/Industry Codes: 327213 Glass Container Manufacturing; NAICS/Industry Codes: 311991 Perishable Prepared Food Manufacturing; NAICS/Industry Codes: 311999 All Other Miscellaneous Food Manufacturing; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2009.01.004
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shimakawa, Tomoko
AU - Weingaertner, David W.
AU - Schmit, Diane M.
AU - Brandt, Mary M.
T1 - Development of downloadable and printable posters for nutrition information of raw fruits, vegetables, and fish
JO - Journal of Food Composition & Analysis
JF - Journal of Food Composition & Analysis
Y1 - 2009/12/02/Dec2009 Supplement
VL - 22
M3 - Article
SP - S93
EP - S98
SN - 08891575
AB - Abstract: In the United States, nutrition labeling for raw fruits, vegetables, and fish is currently voluntary. In order to encourage retail stores that sell these foods to participate in the voluntary nutrition labeling program and to be compliant with the guidelines, the United States Food and Drug Administration (FDA) has developed downloadable and printable posters containing nutrition information for the 20 most frequently consumed raw fruits, vegetables, and fish in the United States. The FDA has made the posters available on its website (http://www.cfsan.fda.gov/nutinfo.html), and has urged retail stores to download and print the posters and to display them in their stores for consumers to use in making purchase decisions. In developing these posters, FDA followed the agency''s guidelines for voluntary nutrition labeling. The names and nutrition labeling values for the raw fruits, vegetables and fish are based on the updated nutrition labeling regulation published in the Federal Register on August 17, 2006, which corrected the July 25, 2006 final rule. FDA issued a Constituent Update (electronic newsletter) and contacted trade associations representing retail food stores to inform them about the posters. [Copyright &y& Elsevier]
AB - Copyright of Journal of Food Composition & Analysis is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - FOOD -- Composition
KW - VEGETABLES in human nutrition
KW - FRUIT in human nutrition
KW - FISH as food
KW - INFORMATION dissemination
KW - FOOD labeling
KW - UNITED States
KW - Fish
KW - Food composition
KW - Food data
KW - Fruits
KW - Information dissemination
KW - Nutrition education
KW - Nutrition labeling
KW - US Food and Drug Administration
KW - Vegetables
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 45578817; Shimakawa, Tomoko 1; Email Address: Tomoko.Shimakawa@fda.hhs.gov Weingaertner, David W. 2 Schmit, Diane M. 3 Brandt, Mary M. 1; Affiliation: 1: Office of Nutrition, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-830, College Park, MD 20740-3835, USA 2: Office of the Commissioner, U.S. Food and Drug Administration, Rockville, MD, USA 3: Computer Technology Services, Inc., Rockville, MD, USA; Source Info: Dec2009 Supplement, Vol. 22, pS93; Subject Term: FOOD -- Composition; Subject Term: VEGETABLES in human nutrition; Subject Term: FRUIT in human nutrition; Subject Term: FISH as food; Subject Term: INFORMATION dissemination; Subject Term: FOOD labeling; Subject Term: UNITED States; Author-Supplied Keyword: Fish; Author-Supplied Keyword: Food composition; Author-Supplied Keyword: Food data; Author-Supplied Keyword: Fruits; Author-Supplied Keyword: Information dissemination; Author-Supplied Keyword: Nutrition education; Author-Supplied Keyword: Nutrition labeling; Author-Supplied Keyword: US Food and Drug Administration; Author-Supplied Keyword: Vegetables; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 413140 Fish and seafood product merchant wholesalers; NAICS/Industry Codes: 445220 Fish and Seafood Markets; NAICS/Industry Codes: 561910 Packaging and Labeling Services; Number of Pages: 0p; Document Type: Article
L3 - 10.1016/j.jfca.2009.02.002
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45578817&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kenney, Mary Kay
T1 - Oral Health Care in CSHCN: State Medicaid Policy Considerations.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/12/02/Dec2009 Supplement 4
VL - 124
M3 - Article
SP - S384
EP - S391
SN - 00314005
AB - OBJECTIVE: Low dental care service utilization among Medicaid-enrolled children has often been attributed to low Medicaid reimbursement levels. The purpose of this study was to provide estimates of preventive dental care utilization by Medicaid-enrolled children with special health care needs (CSHCN) and investigate the association of Medicaid preventive dental care reimbursement levels with the receipt of preventive dental care. METHODS: We analyzed data for 40 256 CSHCN (1-17 years of age). Unadjusted estimates of not needing, needing and receiving, and needing but not receiving preventive dental care are presented. Multilevel logistic regression models were fitted to examine associations between state Medicaid dental-procedure reimbursement and receipt of preventive dental care. RESULTS: Some significant associations were found between state-level Medicaid dental-procedure reimbursements and receipt of preventive dental care. The strongest individual-level factor associated with not receiving needed preventive dental care was not receiving needed preventive medical care. Parents of Medicaid-enrolled CSHCN were less likely to report receiving needed preventive dental care and more likely to report not needing or not receiving preventive dental care than non-Medicaid-enrolled CSHCN. CONCLUSIONS: Medicaid-enrolled CSHCN received less needed preventive dental care than non-Medicaid-enrolled CSHCN. An important link to receiving appropriate dental care may be the primary care provider. Raising the level of preventive dental care reimbursement along with other policy changes should increase the frequency of CSHCN receiving preventive dental services. State Medicaid agencies must develop models of medical-dental care management for CSHCN in their programs to ensure the most appropriate care. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHILDREN -- Dental care
KW - HEALTH surveys -- United States
KW - CHILDREN with disabilities -- Care
KW - CHILDREN -- Health
KW - NEEDS assessment (Medical care)
KW - CHILD health services
KW - MEDICAID
KW - CHILD health insurance
KW - UNITED States
KW - children with special health care needs
KW - Medicaid
KW - National Survey of Children With Special Health Care Needs 2005-2006
KW - oral health policy
KW - preventive dental care
N1 - Accession Number: 47153781; Kenney, Mary Kay 1; Email Address: mkenney@hrsa.gov; Affiliation: 1: Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Maryland; Source Info: Dec2009 Supplement 4, Vol. 124, pS384; Subject Term: CHILDREN -- Dental care; Subject Term: HEALTH surveys -- United States; Subject Term: CHILDREN with disabilities -- Care; Subject Term: CHILDREN -- Health; Subject Term: NEEDS assessment (Medical care); Subject Term: CHILD health services; Subject Term: MEDICAID; Subject Term: CHILD health insurance; Subject Term: UNITED States; Author-Supplied Keyword: children with special health care needs; Author-Supplied Keyword: Medicaid; Author-Supplied Keyword: National Survey of Children With Special Health Care Needs 2005-2006; Author-Supplied Keyword: oral health policy; Author-Supplied Keyword: preventive dental care; NAICS/Industry Codes: 923130 Administration of Human Resource Programs (except Education, Public Health, and Veterans' Affairs Programs); Number of Pages: 8p; Document Type: Article
L3 - 10.1542/peds.2009-12551
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DP - EBSCOhost
DB - aph
ER -
TY - NEWS
AU - Birnkrant, Debra
AU - Cox, Edward
T1 - The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza.
JO - New England Journal of Medicine
JF - New England Journal of Medicine
Y1 - 2009/12/03/
VL - 361
IS - 23
M3 - Editorial
SP - 2204
EP - 2207
SN - 00284793
AB - The authors reflect on the decision of U.S. Food and Drug Administration (FDA) Commissioner Margaret Hamburg to issue an Emergency Use Authorization (EUA) regarding the use of the inhibitor peramivir for the treatment of H1N1 influenza on October 23, 2009. According to them, the authority of the agency to issue an EUA was approved by the Congress under the Project Bioshield Act of 2004. They also mention that an authorization for a medical product has a year term, however, it can be renewed based on the emergency circumstances.
KW - H1N1 (2009) influenza
KW - INFLUENZA -- Treatment
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - HAMBURG, Margaret A., 1955-
N1 - Accession Number: 45660540; Birnkrant, Debra 1 Cox, Edward 1; Affiliation: 1: Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD; Source Info: 12/3/2009, Vol. 361 Issue 23, p2204; Subject Term: H1N1 (2009) influenza; Subject Term: INFLUENZA -- Treatment; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; People: HAMBURG, Margaret A., 1955-; Number of Pages: 4p; Document Type: Editorial; Full Text Word Count: 1499
L3 - 10.1056/NEJMp0910479
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105257831
T1 - The Emergency Use Authorization of peramivir for treatment of 2009 H1N1 influenza.
AU - Birnkrant D
AU - Cox E
Y1 - 2009/12/03/
N1 - Accession Number: 105257831. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article. Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA. NLM UID: 0255562.
KW - Antiviral Agents -- Therapeutic Use
KW - Hydrocarbons, Alicyclic -- Therapeutic Use
KW - Drug Approval
KW - Drugs, Investigational -- Therapeutic Use
KW - Organic Chemicals -- Therapeutic Use
KW - Influenza A Virus, H1N1 Subtype
KW - Influenza, Human -- Drug Therapy
KW - Glycoside Hydrolases -- Antagonists and Inhibitors
KW - Emergencies
KW - Enzyme Inhibitors -- Therapeutic Use
KW - Injections, Intravenous
KW - United States
KW - United States Food and Drug Administration
SP - 2204
EP - 2207
JO - New England Journal of Medicine
JF - New England Journal of Medicine
JA - N ENGL J MED
VL - 361
IS - 23
CY - Waltham, Massachusetts
PB - New England Journal of Medicine
SN - 0028-4793
AD - Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
U2 - PMID: 19884645.
DO - 10.1056/NEJMp0910479
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DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Gellin, Bruce G.
AU - Shen, Angela K.
T1 - Financing Vaccines: Cornerstone of Prevention.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/12/03/Dec2009 Supplement 5
VL - 124
M3 - Opinion
SP - S457
EP - S458
SN - 00314005
AB - In this article, the author discusses the impact of American Recovery and Reinvestment Act of 2009 (ARRA) on the vaccine financing programs in the U.S. He explains that ARRA played a fundamental role in the country's preventive health services including vaccination. He mentions that ARRA should also help expand national public awareness and knowledge of the benefits of vaccines in reducing vaccine-preventable diseases.
KW - PREVENTIVE health services
KW - COMMUNICABLE diseases -- Prevention
KW - VACCINES
KW - GOVERNMENT policy
KW - PREVENTIVE medicine
KW - UNITED States
KW - American Recovery and Reinvestment Act of 2009
KW - financing
KW - immunizations
KW - policy
KW - prevention
KW - public health
KW - vaccines
KW - UNITED States. American Recovery & Reinvestment Act of 2009
N1 - Accession Number: 47122447; Gellin, Bruce G. 1; Email Address: bruce.gellin@hhs.gov Shen, Angela K. 1; Affiliation: 1: National Vaccine Program Office, US Department of Health and Human Services, Washington, DC; Source Info: Dec2009 Supplement 5, Vol. 124, pS457; Subject Term: PREVENTIVE health services; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: VACCINES; Subject Term: GOVERNMENT policy; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Author-Supplied Keyword: American Recovery and Reinvestment Act of 2009; Author-Supplied Keyword: financing; Author-Supplied Keyword: immunizations; Author-Supplied Keyword: policy; Author-Supplied Keyword: prevention; Author-Supplied Keyword: public health; Author-Supplied Keyword: vaccines; Reviews & Products: UNITED States. American Recovery & Reinvestment Act of 2009; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 2p; Document Type: Opinion
L3 - 10.1542/peds.2009-1542D
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DB - aph
ER -
TY - JOUR
AU - Shen, Angela K.
AU - Hunsaker, John
AU - Gazmararian, Julie A.
AU - Lindley, Megan C.
AU - Birkhead, Guthrie S.
T1 - Role of Health Insurance in Financing Vaccinations for Children and Adolescents in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/12/03/Dec2009 Supplement 5
VL - 124
M3 - Article
SP - S522
EP - S531
SN - 00314005
AB - OBJECTIVE: The goal was to elicit perspectives of selected health insurance plan medical or quality improvement directors regarding factors related to coverage and reimbursement and perceptions of financing as a barrier to child and adolescent immunization. METHODS: Medical or quality improvement directors from 20 plans selected by America's Health Insurance Plans were invited to complete an online survey in July 2007. Respondents who agreed to follow-up interviews were invited to participate in telephone interviews conducted by Centers for Disease Control and Prevention staff members in August 2007. RESULTS: Fifteen plans (representing >67 million enrollees) responded to the online survey. All respondents covered all Advisory Committee on Immunization Practices-recommended child and adolescent vaccines in all or most products. Advisory Committee on Immunization Practices recommendations were the most commonly cited criteria for coverage decisions (86.7%) and coverage modifications (100%). Factors affecting reimbursement that were cited most often were manufacturer's vaccine price (80%) and physician feedback (53.3%). In follow-up interviews with 10 self-selected respondents, manufacturer's price (7 of 10 plans) and physician feedback (4 of 10 plans) were identified as the most-important factors affecting reimbursement. Respondents said that reimbursement delays were most commonly attributable to providers' claim submission errors or patient ineligibility. Some respondents thought that vaccine financing was a barrier (4 of 10 plans) or somewhat a barrier (2 of 10 plans) to providing immunizations; others (4 of 10 plans) did not. CONCLUSION: Although these data suggest that health insurance coverage for recommended vaccines is high, coverage is not universal across all products offered. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - OVERHEAD costs
KW - MEDICAL care costs
KW - TEENAGERS -- Health
KW - HEALTH insurance -- Self-insurance
KW - MEDICALLY uninsured persons
KW - COMMUNICABLE diseases -- Prevention
KW - MEDICAL policy
KW - IMMUNIZATION
KW - PEDIATRICS
KW - PREVENTIVE medicine
KW - UNITED States
KW - cost
KW - coverage
KW - health insurance
KW - immunization
KW - reimbursement
KW - vaccination
KW - vaccine
N1 - Accession Number: 47122455; Shen, Angela K. 1; Email Address: angela.shen@hhs.gov Hunsaker, John 2 Gazmararian, Julie A. 3 Lindley, Megan C. 4 Birkhead, Guthrie S. 5,6,7; Affiliation: 1: National Vaccine Program Office, US Department of Health and Human Services, Washington, DC 2: Department of Clinical Affairs and Strategic Planning, America's Health Insurance Plans, Washington, DC 3: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 4: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 5: Office of Public Health, New York State Department of Health, Albany, New York 6: Department of Epidemiology, School of Public Health, University at Albany, Albany New York 7: National Vaccine Advisory Committee, Washington, DC; Source Info: Dec2009 Supplement 5, Vol. 124, pS522; Subject Term: OVERHEAD costs; Subject Term: MEDICAL care costs; Subject Term: TEENAGERS -- Health; Subject Term: HEALTH insurance -- Self-insurance; Subject Term: MEDICALLY uninsured persons; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: MEDICAL policy; Subject Term: IMMUNIZATION; Subject Term: PEDIATRICS; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Author-Supplied Keyword: cost; Author-Supplied Keyword: coverage; Author-Supplied Keyword: health insurance; Author-Supplied Keyword: immunization; Author-Supplied Keyword: reimbursement; Author-Supplied Keyword: vaccination; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 10p; Document Type: Article
L3 - 10.1542/peds.2009-1542L
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=47122455&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shen, Angela K.
AU - Rodewald, Lance E.
AU - Birkhead, Guthrie S.
T1 - Perspective of Vaccine Manufacturers on Financing Pediatric and Adolescent Vaccines in the United States.
JO - Pediatrics
JF - Pediatrics
Y1 - 2009/12/03/Dec2009 Supplement 5
VL - 124
M3 - Article
SP - S540
EP - S547
SN - 00314005
AB - OBJECTIVE: The goal was to understand vaccine manufacturers' perspectives on vaccine financing as a barrier to immunization. METHODS: Individual telephone interviews with representatives of the 6 manufacturers that produce routinely recommended vaccines for children and adolescents in the United States were conducted in November and December 2006. RESULTS: Although manufacturers acknowledged that the price of newer vaccines presents challenges to optimal vaccine use, they asserted that children and adolescents have access to vaccinations through public and private insurance. Respondents suggested that the system could be improved through adequate funding of the public- sector safety net. Respondents stated that providers should receive timely reimbursement for the full costs of vaccine purchase and administration, and manufacturers who sell directly to health care providers may provide flexible payment terms for vaccine purchases. Manufacturers supported targeted expansion of the Vaccines for Children program to allow children with incomplete insurance coverage for vaccines to receive vaccines at health department clinics. Manufacturers perceived delays in publication of Advisory Committee on Immunization Practices recommendations as a potential barrier to vaccine uptake. They viewed the perceived lack of public value for vaccines as a potential barrier to adequate reimbursement and optimal utilization. Respondents also maintained that their ability to negotiate vaccine prices through the private market is a crucial priority. CONCLUSIONS: Manufacturers assert that children and adolescents have access to immunizations through public and private insurance. Manufacturers think that they have mitigated the challenge most directly in their control: the large financial outlays required for up-front vaccine purchases. [ABSTRACT FROM AUTHOR]
AB - Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - COMMUNICABLE diseases -- Prevention
KW - PUBLIC health -- United States
KW - MEDICALLY uninsured persons
KW - HEALTH insurance
KW - IMMUNIZATION
KW - GOVERNMENT policy
KW - IMMUNOTHERAPY
KW - MEDICAL policy
KW - PEDIATRICS
KW - PREVENTIVE medicine
KW - UNITED States
KW - financing
KW - immunization
KW - manufacturers
KW - vaccination
KW - vaccine
N1 - Accession Number: 47122457; Shen, Angela K. 1; Email Address: angela.shen@hhs.gov Rodewald, Lance E. 2 Birkhead, Guthrie S. 3,4,5; Affiliation: 1: National Vaccine Program Office, US Department of Health and Human Services, Washington, DC 2: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 3: Office of Public Health, New York State Department of Health, Albany, New York 4: Department of Epidemiology, School of Public Health, University at Albany, Albany, New York 5: National Vaccine Advisory Committee, Washington, DC; Source Info: Dec2009 Supplement 5, Vol. 124, pS540; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: PUBLIC health -- United States; Subject Term: MEDICALLY uninsured persons; Subject Term: HEALTH insurance; Subject Term: IMMUNIZATION; Subject Term: GOVERNMENT policy; Subject Term: IMMUNOTHERAPY; Subject Term: MEDICAL policy; Subject Term: PEDIATRICS; Subject Term: PREVENTIVE medicine; Subject Term: UNITED States; Author-Supplied Keyword: financing; Author-Supplied Keyword: immunization; Author-Supplied Keyword: manufacturers; Author-Supplied Keyword: vaccination; Author-Supplied Keyword: vaccine; NAICS/Industry Codes: 524111 Direct individual life, health and medical insurance carriers; NAICS/Industry Codes: 524112 Direct group life, health and medical insurance carriers; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 8p; Illustrations: 1 Chart, 3 Graphs; Document Type: Article
L3 - 10.1542/peds.2009-1542N
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Dworkin, Robert H.
AU - Turk, Dennis C.
AU - McDermott, Michael P.
AU - Peirce-Sandner, Sarah
AU - Burke, Laurie B.
AU - Cowan, Penney
AU - Farrar, John T.
AU - Hertz, Sharon
AU - Raja, Srinivasa N.
AU - Rappaport, Bob A.
AU - Rauschkolb, Christine
AU - Sampaio, Cristina
T1 - Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations
JO - Pain (03043959)
JF - Pain (03043959)
Y1 - 2009/12/05/
VL - 146
IS - 3
M3 - Article
SP - 238
EP - 244
SN - 03043959
AB - Abstract: An essential component of the interpretation of results of randomized clinical trials of treatments for chronic pain involves the determination of their clinical importance or meaningfulness. This involves two distinct processes—interpreting the clinical importance of individual patient improvements and the clinical importance of group differences—which are frequently misunderstood. In this article, we first describe the essential differences between the interpretation of the clinical importance of patient improvements and of group differences. We then discuss the factors to consider when evaluating the clinical importance of group differences, which include the results of responder analyses of the primary outcome measure, the treatment effect size compared to available therapies, analyses of secondary efficacy endpoints, the safety and tolerability of treatment, the rapidity of onset and durability of the treatment benefit, convenience, cost, limitations of existing treatments, and other factors. The clinical importance of individual patient improvements can be determined by assessing what patients themselves consider meaningful improvement using well-described methods. In contrast, the clinical meaningfulness of group differences must be determined by a multi-factorial evaluation of the benefits and risks of the treatment and of other available treatments for the condition in light of the primary goals of therapy. Such determinations must be conducted on a case-by-case basis, and are ideally informed by patients and their significant others, clinicians, researchers, statisticians, and representatives of society at large. [Copyright &y& Elsevier]
AB - Copyright of Pain (03043959) is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CHRONIC pain -- Treatment
KW - CHRONICALLY ill
KW - CLINICAL trials
KW - EFFECT sizes (Statistics)
KW - CHRONIC diseases -- Risk factors
KW - MEDICAL care
KW - MEDICAL research
KW - Chronic pain
KW - Clinical importance
KW - Clinical meaningfulness
KW - Effect size
KW - Group differences
KW - Randomized clinical trials
N1 - Accession Number: 45071381; Dworkin, Robert H. 1; Email Address: robert_dworkin@urmc.rochester.edu Turk, Dennis C. 2 McDermott, Michael P. 3 Peirce-Sandner, Sarah 4 Burke, Laurie B. 5 Cowan, Penney 6 Farrar, John T. 7 Hertz, Sharon 5 Raja, Srinivasa N. 8 Rappaport, Bob A. 5 Rauschkolb, Christine 9 Sampaio, Cristina 10; Affiliation: 1: Departments of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA 2: Department of Anesthesiology, University of Washington, Seattle, WA, USA 3: Departments of Biostatistics and Computational Biology and Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA 4: Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA 5: United States Food and Drug Administration, Bethesda, MD, USA 6: American Chronic Pain Association, Rocklin, CA, USA 7: Department of Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA 8: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA 9: Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ, USA 10: Faculdade de Medicina de Lisboa, Portugal; Source Info: Dec2009, Vol. 146 Issue 3, p238; Subject Term: CHRONIC pain -- Treatment; Subject Term: CHRONICALLY ill; Subject Term: CLINICAL trials; Subject Term: EFFECT sizes (Statistics); Subject Term: CHRONIC diseases -- Risk factors; Subject Term: MEDICAL care; Subject Term: MEDICAL research; Author-Supplied Keyword: Chronic pain; Author-Supplied Keyword: Clinical importance; Author-Supplied Keyword: Clinical meaningfulness; Author-Supplied Keyword: Effect size; Author-Supplied Keyword: Group differences; Author-Supplied Keyword: Randomized clinical trials; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); Number of Pages: 7p; Document Type: Article
L3 - 10.1016/j.pain.2009.08.019
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hogg, R. A.
AU - Wessels, J.
AU - Hart, J.
AU - Efstratiou, A.
AU - de Zoysa, A.
AU - Mann, G.
AU - Allen, T.
AU - Pritchard, G. C.
T1 - Possible zoonotic transmission of toxigenic Corynebacterium ulcerans from companion animals in a human case of fatal diphtheria.
JO - Veterinary Record: Journal of the British Veterinary Association
JF - Veterinary Record: Journal of the British Veterinary Association
Y1 - 2009/12/05/
VL - 165
IS - 23
M3 - Article
SP - 691
EP - 692
SN - 00424900
AB - The article presents an analysis on the transmission of toxigenic corynebacterium ulcerans (c. ulcerans) from animals to human beings through diphtheria. It cites that the c. ulcerans, which are known to cause animal diseases, were discovered in an old woman with diphtheria who eventually died even if she was given antitoxins and antibiotics. It notes that cats with nasal discharge are considered to be a source for human c. ulcerans infection in Great Britain.
KW - CORYNEBACTERIUM diseases
KW - ANIMALS as carriers of disease
KW - DIPHTHERIA
KW - ANTITOXINS
KW - ANTIBIOTICS
KW - TRANSMISSION
KW - GREAT Britain
N1 - Accession Number: 47168189; Hogg, R. A. 1; Email Address: r.hogg@vla.defra.gsi.gov.uk Wessels, J. 1 Hart, J. 2 Efstratiou, A. 3 de Zoysa, A. 3 Mann, G. 3 Allen, T. 4 Pritchard, G. C. 5; Affiliation: 1: Veterinary Laboratories Agency - Preston, Barton Hall, Garstang Road, Barton, Preston PR3 5HE 2: North Wales Health Protection Team, National Public Health Service for Wales, Preswylfa, Hendy Road, Mold, Flintshire CH7 1PZ 3: WHO Collaborating Centre for Diphtheria and Streptococcal Infections, Respiratory and Systemic Infections Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT 4: Food and Environmental Microbiology Services North West, Preston Microbiology Services, Royal Preston Hospital, Sharoe Green Lane, Preston PR2 9HT 5: Veterinary Laboratories Agency - Bury St Edmunds, Rougham Hill, Bury St Edmunds, Suffolk IP33 2RX; Source Info: 12/5/2009, Vol. 165 Issue 23, p691; Subject Term: CORYNEBACTERIUM diseases; Subject Term: ANIMALS as carriers of disease; Subject Term: DIPHTHERIA; Subject Term: ANTITOXINS; Subject Term: ANTIBIOTICS; Subject Term: TRANSMISSION; Subject Term: GREAT Britain; NAICS/Industry Codes: 325411 Medicinal and Botanical Manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 2p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Brazeau, Gayle A.
AU - Meyer, Susan M.
AU - Belsey, Michele
AU - Bednarczyk, Edward M.
AU - Bilic, Sanela
AU - Bullock, Julie
AU - DeLander, Gary E.
AU - Fiese, E. F.
AU - Giroux, Stephen L.
AU - McNatty, Danny
AU - Nemire, Ruth
AU - Prescott Jr., William A.
AU - Traynor, Andrew P.
T1 - Preparing Pharmacy Graduates for Traditional and Emerging Career Opportunities.
JO - American Journal of Pharmaceutical Education
JF - American Journal of Pharmaceutical Education
Y1 - 2009/12/10/
VL - 73
IS - 8
M3 - Article
SP - 1
EP - 12
SN - 00029459
AB - Educational programs in pharmacy must focus on educating pharmacists of the future who are prepared to serve as competent and confident health care "providers" whose "practice" can occur in any number of current and future settings; and whose expertise is essential to an interprofessional health care team. Graduates must be able to incorporate a scholarly approach to their practice in identifying patient care problems; practicing in an evidence-based manner; and ensuring safe, effective, and appropriate use of medications. It is time for colleges and schools of pharmacy to implement contemporary teaching and assessment strategies that facilitate effective and efficient student learning that is focused at the graduate professional level, to evolve the content around which the curriculum is organized, and clearly articulate the abilities graduates must have to function effectively in the myriad professional roles in which they may find themselves. [ABSTRACT FROM AUTHOR]
AB - Copyright of American Journal of Pharmaceutical Education is the property of American Association of Colleges of Pharmacy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - EDUCATIONAL programs
KW - PHARMACISTS
KW - INTERPROFESSIONAL education
KW - HEALTH care teams
KW - PHARMACY colleges
KW - OCCUPATIONAL roles
KW - EDUCATION (Continuing education)
N1 - Accession Number: 67252298; Brazeau, Gayle A. 1; Email Address: gbrazeau@buffalo.edu Meyer, Susan M. 2 Belsey, Michele 3 Bednarczyk, Edward M. 1 Bilic, Sanela 4 Bullock, Julie 5 DeLander, Gary E. 6 Fiese, E. F. 7 Giroux, Stephen L. 8 McNatty, Danny 9 Nemire, Ruth 10 Prescott Jr., William A. 1 Traynor, Andrew P. 11; Affiliation: 1: School of Pharmacy and Pharmaceutical Sciences, University at Buffalo 2: School of Pharmacy, University of Pittsburgh 3: Rite Aid Corporation, Camp Hill, PA 4: Novartis Pharmaceuticals, Florham Park, NJ 5: Food and Drug Administration, Silver Spring, MD 6: College of Pharmacy, Oregon State University 7: Pfizer, Inc, Groton, CT 8: Modem-Giroux, Inc/Middleport Family Health Center, NY 9: College of Pharmacy, Midwestern University 10: Touro College of Pharmacy - New York 11: College of Pharmacy, University of Minnesota-Duluth; Source Info: Dec2009, Vol. 73 Issue 8, p1; Subject Term: EDUCATIONAL programs; Subject Term: PHARMACISTS; Subject Term: INTERPROFESSIONAL education; Subject Term: HEALTH care teams; Subject Term: PHARMACY colleges; Subject Term: OCCUPATIONAL roles; Subject Term: EDUCATION (Continuing education); NAICS/Industry Codes: 446110 Pharmacies and Drug Stores; Number of Pages: 12p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kehrer, James P.
AU - Brazeau, Gayle A.
AU - DeGuire, Nancy
AU - Dopp, Anna Legreid
AU - Orrico, Kathy B.
AU - Marchand, Heidi C.
AU - Lang, William G.
T1 - Report of the 2008-2009 Standing Committee on Advocacy.
JO - American Journal of Pharmaceutical Education
JF - American Journal of Pharmaceutical Education
Y1 - 2009/12/10/
VL - 73
IS - 8
M3 - Article
SP - 1
EP - 11
SN - 00029459
AB - The article discusses the annual report of the American Association of Colleges of Pharmacy (AACP) Standing Committee on Advocacy for 2008-2009. Topics include public health, the U.S. Food and Drug Administration (FDA), and pharmacy education. It also notes the FDA Amendments Act (FDAAA) of 2007 that focuses on helping the FDA through the academic pharmacy faculty.
KW - PUBLIC health
KW - PHARMACY -- Study & teaching
KW - COMMITTEE reports
KW - UNITED States
KW - UNITED States. Food & Drug Administration
KW - AMERICAN Association of Colleges of Pharmacy
N1 - Accession Number: 67252262; Kehrer, James P. 1 Brazeau, Gayle A. 2 DeGuire, Nancy 3 Dopp, Anna Legreid 4 Orrico, Kathy B. 5 Marchand, Heidi C. 6 Lang, William G.; Affiliation: 1: College of Pharmacy, Washington State University 2: School of Pharmacy and Pharmaceutical Sciences, University of Buffalo 3: Thomas J. Long School of Pharmacy and Health Sciences 4: School of Pharmacy, University of Wisconsin-Madison 5: School of Pharmacy, University of California, San Francisco 6: Office of Special Health Projects, U.S. Food and Drug Administration; Source Info: Dec2009, Vol. 73 Issue 8, p1; Subject Term: PUBLIC health; Subject Term: PHARMACY -- Study & teaching; Subject Term: COMMITTEE reports; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration Company/Entity: AMERICAN Association of Colleges of Pharmacy; NAICS/Industry Codes: 525120 Health and Welfare Funds; Number of Pages: 11p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Kolibab, Kristopher
AU - Parra, Marcela
AU - Yang, Amy L.
AU - Perera, Liyanage P.
AU - Derrick, Steven C.
AU - Morris, Sheldon L.
T1 - A practical in vitro growth inhibition assay for the evaluation of TB vaccines
JO - Vaccine
JF - Vaccine
Y1 - 2009/12/11/
VL - 28
IS - 2
M3 - Article
SP - 317
EP - 322
SN - 0264410X
AB - Abstract: New vaccines and novel immunization strategies are needed to improve the control of the global tuberculosis epidemic. To facilitate vaccine development, we have been creating in vitro mycobacterial intra-macrophage growth inhibition assays. Here we describe the development of an in vitro assay designed for BSL-2 laboratories which measures the capacity of vaccine-induced immune splenocytes to control the growth of isoniazid-resistant Mycobacterium bovis BCG (INHr BCG). The use of the INHr BCG as the infecting organism allows the discrimination of BCG bacilli used in murine vaccinations from BCG used in the in vitro assay. In this study, we showed that protective immune responses evoked by four different types of Mycobacterium tuberculosis vaccines [BCG, an ESAT6/Antigen 85B fusion protein formulated in DDA/MPL adjuvant, a DNA vaccine expressing the same fusion protein, and a TB Modified Vaccinia Ankara construct expressing four TB antigens (MVA-4TB)] were detected. Importantly, the levels of vaccine-induced protective immunity seen in the in vitro assay correlated with the results from in vivo protection studies in the mouse model of pulmonary tuberculosis. Furthermore, the growth inhibition data for the INHr BCG assay was similar to the previously reported results for a M. tuberculosis infection assay. The cytokine expression profiles at day 7 of the INHr BCG growth inhibition studies were also similar but not identical to the cytokine patterns detected in earlier M. tuberculosis co-culture assays. Overall, we have shown that a BSL-2 compatible in vitro growth inhibition assay using INHr BCG as the intra-macrophage target organism should be useful in developing and evaluating new TB immunization strategies. [Copyright &y& Elsevier]
AB - Copyright of Vaccine is the property of Elsevier Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - VACCINATION
KW - Epidemics
KW - Bacterial growth
KW - Tuberculosis
KW - Drug development
KW - Macrophages
KW - BCG vaccination
KW - Mice as laboratory animals
KW - Mycobacterium bovis
KW - Drug resistance in microorganisms
KW - Cytokines
KW - In vitro assay
KW - Mouse
KW - Tuberculosis
KW - Vaccine
N1 - Accession Number: 45642206; Kolibab, Kristopher 1; Parra, Marcela 1; Yang, Amy L. 1; Perera, Liyanage P. 2; Derrick, Steven C. 1; Morris, Sheldon L. 1; Email Address: sheldon.morris@fda.hhs.gov; Affiliations: 1: Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD, United States; 2: Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD, United States; Issue Info: Dec2009, Vol. 28 Issue 2, p317; Thesaurus Term: VACCINATION; Thesaurus Term: Epidemics; Thesaurus Term: Bacterial growth; Subject Term: Tuberculosis; Subject Term: Drug development; Subject Term: Macrophages; Subject Term: BCG vaccination; Subject Term: Mice as laboratory animals; Subject Term: Mycobacterium bovis; Subject Term: Drug resistance in microorganisms; Author-Supplied Keyword: Cytokines; Author-Supplied Keyword: In vitro assay; Author-Supplied Keyword: Mouse; Author-Supplied Keyword: Tuberculosis; Author-Supplied Keyword: Vaccine; NAICS/Industry Codes: 112990 All Other Animal Production; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.vaccine.2009.10.047
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DP - EBSCOhost
DB - eih
ER -
TY - JOUR
AU - Van Ballegooijen, W. Marijn
AU - Van Houdt, Robin
AU - Bruisten, Sylvia M.
AU - Boot, Hein J.
AU - Coutinho, Roel A.
AU - Wallinga, Jacco
T1 - Molecular Sequence Data of Hepatitis B Virus and Genetic Diversity After Vaccination.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/12/15/
VL - 170
IS - 12
M3 - Article
SP - 1455
EP - 1463
SN - 00029262
AB - The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer a complementary tool to assess transmission. Here, the authors investigate the added value of using viral sequence data to monitor a vaccination program that was started in 1998 and was targeted against hepatitis B virus in men who have sex with men in Amsterdam, the Netherlands. The incidence in this target group, as estimated from the notifications of acute infections with hepatitis B virus, was low; therefore, there was insufficient power to show a significant change in incidence. In contrast, the genetic diversity, as estimated from the viral sequence collected from the target group, revealed a marked decrease after vaccination was introduced. Taken together, the findings suggest that introduction of vaccination coincided with a change in the target group toward behavior with a higher risk of infection. The authors argue that molecular sequence data provide a powerful additional monitoring instrument, next to conventional case registration, for assessing the impact of vaccination. [ABSTRACT FROM PUBLISHER]
AB - Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HEPATITIS B virus
KW - COMMUNICABLE diseases -- Prevention
KW - COMMUNICABLE diseases -- Transmission
KW - HEPATITIS B -- Vaccination
KW - IMMUNIZATION
KW - MOLECULES
KW - communicable diseases
KW - disease notification
KW - disease transmission, infectious
KW - genetic variation
KW - hepatitis B virus
KW - molecular sequence data
KW - vaccination
N1 - Accession Number: 47145120; Van Ballegooijen, W. Marijn 1; Email Address: marijn.van.ballegooijen@rivm.nl Van Houdt, Robin 2 Bruisten, Sylvia M. 2 Boot, Hein J. 1 Coutinho, Roel A. 1,3 Wallinga, Jacco 1,4; Affiliation: 1: Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands 2: Department of Infectious Diseases, Public Health Service, GGD, Amsterdam, the Netherlands 3: Department of Human Retrovirology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands 4: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Source Info: Dec2009, Vol. 170 Issue 12, p1455; Subject Term: HEPATITIS B virus; Subject Term: COMMUNICABLE diseases -- Prevention; Subject Term: COMMUNICABLE diseases -- Transmission; Subject Term: HEPATITIS B -- Vaccination; Subject Term: IMMUNIZATION; Subject Term: MOLECULES; Author-Supplied Keyword: communicable diseases; Author-Supplied Keyword: disease notification; Author-Supplied Keyword: disease transmission, infectious; Author-Supplied Keyword: genetic variation; Author-Supplied Keyword: hepatitis B virus; Author-Supplied Keyword: molecular sequence data; Author-Supplied Keyword: vaccination; Number of Pages: 9p; Illustrations: 1 Chart, 7 Graphs; Document Type: Article
L3 - 10.1093/aje/kwp375
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Van Ballegooijen, W. Marijn
AU - Van Houdt, Robin
AU - Bruisten, Sylvia M.
AU - Boot, Hein J.
AU - Coutinho, Roel A.
AU - Wallinga, Jacco
T1 - Van Ballegooijen et al. Respond to “Evaluating Vaccination Programs Using Genetic Sequence Data”.
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
Y1 - 2009/12/15/
VL - 170
IS - 12
M3 - Opinion
SP - 1467
EP - 1468
SN - 00029262
AB - A response by W. Marijnvan Ballegooijen and colleagues to a commentary to their article "Evaluating Vaccination Programs Using Genetic Sequence Data" is presented. It explains the changes in genetic diversity, along with the role of genetic diversity in making inferences. It argues in support of the critics' claim that the Bayesian skyline plot should not be used to assess a decline in genetic diversity. The authors commend their critics for presenting a description of idealized data sets.
KW - GENETICS
KW - VACCINATION
KW - IMMUNIZATION
KW - BIODIVERSITY
KW - BAYESIAN analysis
KW - CHARTS, diagrams, etc.
N1 - Accession Number: 47145136; Van Ballegooijen, W. Marijn 1; Email Address: marijn.van.ballegooijen@rivm.nl Van Houdt, Robin 2 Bruisten, Sylvia M. 2 Boot, Hein J. 1 Coutinho, Roel A. 1,3 Wallinga, Jacco 1,4; Affiliation: 1: Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands 2: Department of Infectious Diseases, Public Health Service, GGD, Amsterdam, the Netherlands 3: Department of Human Retrovirology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands 4: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Source Info: Dec2009, Vol. 170 Issue 12, p1467; Subject Term: GENETICS; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: BIODIVERSITY; Subject Term: BAYESIAN analysis; Subject Term: CHARTS, diagrams, etc.; NAICS/Industry Codes: 923120 Administration of Public Health Programs; Number of Pages: 2p; Document Type: Opinion
L3 - 10.1093/aje/kwp368
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhao, S.
AU - Blickenstaff, K.
AU - Glenn, A.
AU - Ayers, S. L.
AU - Friedman, S. L.
AU - Abbott, J. W.
AU - McDermott, P. F.
T1 - β-Lactam Resistance in Salmonella Strains Isolated from Retail Meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006.
JO - Applied & Environmental Microbiology
JF - Applied & Environmental Microbiology
Y1 - 2009/12/15/
VL - 75
IS - 24
M3 - Article
SP - 7624
EP - 7630
SN - 00992240
AB - Ampicillin-resistant (Ampr) Salmonella enterica isolates (n = 344) representing 32 serotypes isolated from retail meats from 2002 to 2006 were tested for susceptibility to 21 other antimicrobial agents and screened for the presence of five beta-lactamase gene families (blaCMY, blaTEM, blaSHV, blaOXA, and blaCTX-M) and class 1 integrons. Among the Ampr isolates, 66.9% were resistant to five or more antimicrobials and 4.9% were resistant to 10 or more antimicrobials. Coresistance to other β-lactams was noted for amoxicillin-clavulanic acid (55.5%), ceftiofur (50%), cefoxitin (50%), and ceftazidime (24.7%), whereas less than 5% of isolates were resistant to piperacillin-tazobactam (4.9%), cefotaxime (3.5%), ceftriaxone (2%), and aztreonam (1.2%). All isolates were susceptible to cefepime, imipenem, and cefquinome. No Salmonella producing extended-spectrum beta-lactamases was found in this study. Approximately 7% of the isolates displayed a typical multidrug-resistant (MDR)-AmpC phenotype, with resistance to ampicillin, chloramphenicol, streptomycin, sulfonamide, tetracycline, plus resistance to amoxicillin-clavulanic acid, cefoxitin, and ceftiofur and with decreased susceptibility to ceftriaxone (MIC 4 μg/ml). Pulsed-field gel electrophoresis results showed that several MDR clones were geographically dispersed in different types of meats throughout the five sampling years. Additionally, 50% of the isolates contained blaCMY, 47% carried blaTEM-1, and 2.6% carried both genes. Only 15% of the isolates harbored class I integrons carrying various combinations of aadA, aadB, and dfrA gene cassettes. The blaCMY, blaTEM, and class 1 integrons were transferable through conjugation and/or transformation. Our findings indicate that a varied spectrum of coresistance traits is present in Ampr Salmonella strains in the meat supply of the United States, with a continued predominance of blaCMY and blaTEM genes in β-lactam-resistant isolates. [ABSTRACT FROM AUTHOR]
AB - Copyright of Applied & Environmental Microbiology is the property of American Society for Microbiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - MICROORGANISMS
KW - SALMONELLA
KW - MICROBIAL sensitivity tests
KW - MEAT
KW - BETA lactamases
KW - ANTI-infective agents
KW - AMOXICILLIN
KW - DRUG resistance in microorganisms
KW - ELECTROPHORESIS
KW - UNITED States
N1 - Accession Number: 47541374; Zhao, S. 1; Email Address: shaohua.zhao@fda.hhs.gov Blickenstaff, K. 1 Glenn, A. 1 Ayers, S. L. 1 Friedman, S. L. 1 Abbott, J. W. 1 McDermott, P. F. 1; Affiliation: 1: Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US. Food and Drug Administration, Laurel, Maryland; Source Info: Dec2009, Vol. 75 Issue 24, p7624; Subject Term: MICROORGANISMS; Subject Term: SALMONELLA; Subject Term: MICROBIAL sensitivity tests; Subject Term: MEAT; Subject Term: BETA lactamases; Subject Term: ANTI-infective agents; Subject Term: AMOXICILLIN; Subject Term: DRUG resistance in microorganisms; Subject Term: ELECTROPHORESIS; Subject Term: UNITED States; NAICS/Industry Codes: 424470 Meat and Meat Product Merchant Wholesalers; NAICS/Industry Codes: 311613 Rendering and Meat Byproduct Processing; NAICS/Industry Codes: 413160 Red meat and meat product merchant wholesalers; NAICS/Industry Codes: 445210 Meat Markets; Number of Pages: 8p; Document Type: Article
L3 - 10.1128/AEM.01158-09
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Hang Xie
AU - Liu, Teresa M.
AU - Xiuhua Lu
AU - Zhengqi Wu
AU - Belser, Jessica A.
AU - Katz, Jacqueline M.
AU - Tumpey, Terrence M.
AU - Zhiping Ye
T1 - A Live Attenuated H1N1 M1 Mutant Provides Broad Cross-Protection against Influenza A Viruses, Including Highly Pathogenic A/Vietnam/1203/2004, in Mice.
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
Y1 - 2009/12/15/
VL - 200
IS - 12
M3 - Article
SP - 1874
EP - 1883
SN - 00221899
AB - The emergence of novel influenza A H1N1 and highly pathogenic avian influenza (HPAI) H5N1 viruses underscores the urgency of developing efficient vaccines against an imminent pandemic. M(NLS-88R) (H1N1), an A/WSN/33 mutant with modifications in the multibasic motif 101RKLKR105 of the matrix (M1) protein and its adjacent region, was generated by reverse genetics. The M(NLS-88R) mutant had in vitro growth characteristics similar to those of wild-type A/WSN/33 (wt-WSN), but it was attenuated in mice. Vaccination with M(NLS-88R) not only fully protected mice from lethal homologous challenges but also prevented mortality caused by antigenically distinct H3N2 and H5N1 viruses. M(NLS-88R)-induced homologous protection was mainly antibody dependent, but cellular immunity was also beneficial in protecting against sublethal wt-WSN infection. Adoptive transfer studies indicated that both humoral and cellular immune responses were crucial for M(NLS-88R)-induced heterologous protection. Our study suggests an alternative approach to attenuate wt influenza viruses for the development of a pandemic vaccine with broad cross-protection. [ABSTRACT FROM AUTHOR]
AB - Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - H1N1 (2009) influenza
KW - INFLUENZA A virus
KW - PATHOGENIC microorganisms
KW - PANDEMICS
KW - INFLUENZA -- Vaccination
KW - GENETICS
KW - MICE as laboratory animals
KW - IMMUNE response
KW - VIETNAM
N1 - Accession Number: 45545621; Hang Xie 1; Email Address: Hang.Xie@fda.hhs.gov Liu, Teresa M. 1 Xiuhua Lu 2 Zhengqi Wu 1 Belser, Jessica A. 2 Katz, Jacqueline M. 2 Tumpey, Terrence M. 2 Zhiping Ye 1; Email Address: Zhiping.Ye@fda.hhs.gov; Affiliation: 1: Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 2: Influenza Division, United States Centers for Diseases Control and Prevention, Atlanta, Georgia; Source Info: 12/15/2009, Vol. 200 Issue 12, p1874; Subject Term: H1N1 (2009) influenza; Subject Term: INFLUENZA A virus; Subject Term: PATHOGENIC microorganisms; Subject Term: PANDEMICS; Subject Term: INFLUENZA -- Vaccination; Subject Term: GENETICS; Subject Term: MICE as laboratory animals; Subject Term: IMMUNE response; Subject Term: VIETNAM; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Illustrations: 1 Chart, 6 Graphs; Document Type: Article
L3 - 10.1086/648405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45545621&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 105249533
T1 - A live attenuated H1N1 M1 mutant provides broad cross-protection against influenza A viruses, including highly pathogenic A/Vietnam/1203/2004, in mice.
AU - Xie H
AU - Liu TM
AU - Lu X
AU - Wu Z
AU - Belser JA
AU - Katz JM
AU - Tumpey TM
AU - Ye Z
Y1 - 2009/12/15/
N1 - Accession Number: 105249533. Language: English. Entry Date: 20100115. Revision Date: 20150711. Publication Type: Journal Article; research. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. NLM UID: 0413675.
KW - Influenza A Virus, H1N1 Subtype -- Immunology
KW - Influenza Vaccine -- Immunology
KW - Mutation
KW - Orthomyxovirus Infections -- Prevention and Control
KW - Proteins
KW - Animal Studies
KW - Antibodies, Viral -- Immunology
KW - Body Weight
KW - Female
KW - Human
KW - Influenza A Virus -- Immunology
KW - Influenza A Virus, H1N1 Subtype
KW - Influenza A Virus, H5N1 Subtype -- Immunology
KW - Lung
KW - Mice
KW - Survival Analysis
KW - T Lymphocytes -- Immunology
KW - Vaccines -- Immunology
KW - Viral Load
SP - 1874
EP - 1883
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
JA - J INFECT DIS
VL - 200
IS - 12
PB - Oxford University Press / USA
AB - The emergence of novel influenza A H1N1 and highly pathogenic avian influenza (HPAI) H5N1 viruses underscores the urgency of developing efficient vaccines against an imminent pandemic. M(NLS-88R) (H1N1), an A/WSN/33 mutant with modifications in the multibasic motif 101RKLKR105 of the matrix (M1) protein and its adjacent region, was generated by reverse genetics. The M(NLS-88R) mutant had in vitro growth characteristics similar to those of wild-type A/WSN/33 (wt-WSN), but it was attenuated in mice. Vaccination with M(NLS-88R) not only fully protected mice from lethal homologous challenges but also prevented mortality caused by antigenically distinct H3N2 and H5N1 viruses. M(NLS-88R)-induced homologous protection was mainly antibody dependent, but cellular immunity was also beneficial in protecting against sublethal wt-WSN infection. Adoptive transfer studies indicated that both humoral and cellular immune responses were crucial for M(NLS-88R)-induced heterologous protection. Our study suggests an alternative approach to attenuate wt influenza viruses for the development of a pandemic vaccine with broad cross-protection.
SN - 0022-1899
AD - Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland, USA. Zhiping.Ye@fda.hhs.gov
U2 - PMID: 19909080.
DO - 10.1086/648405
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=rzh&AN=105249533&site=ehost-live&scope=site
DP - EBSCOhost
DB - rzh
ER -
TY - JOUR
AU - Jaruratanasirikul, Somchit
AU - Sangsupawanich, Pasuree
AU - Koranantakul, Ounjai
AU - Chanvitan, Prasin
AU - Ruaengrairatanaroj, Prasit
AU - Sriplung, Hutcha
AU - Patanasin, Thanomjit
AU - Sukmee, Siriporn
T1 - Maternal iodine status and neonatal thyroid-stimulating hormone concentration: a community survey in Songkhla, southern Thailand.
JO - Public Health Nutrition
JF - Public Health Nutrition
Y1 - 2009/12/15/
VL - 12
IS - 12
M3 - Article
SP - 2279
EP - 2284
SN - 13689800
AB - Objective: To determine iodine intake and urinary iodine excretion (UIE) in a group of pregnant Thai women and the concentration of thyroid-stimulating hormone (TSH) in their neonates. Design: A prospective cohort study. Setting: Three districts of Songkhla, southern Thailand. Subjects: Two hundred and thirty-six pregnant women. Results: A quarter of the participants lacked knowledge of iodine and the prevention of iodine deficiency, although 70% used iodized salt. Those who did not use iodized salt stated that they had no knowledge about iodine (57 %) and no iodized salt was sold in their village (36 %). The median iodine intake in the three districts was 205-240μg/d, with 53-74% of pregnant women having iodine intake <250μg/d. The median UIE in the three districts was 51-106 μg/l, with 24-35% having UIE,50mg/l. The mean neonatal TSH was 2·40 (SD 1·56) mU/l, with 8·9% of neonates having TSH>5 mU/l. Conclusions: The studied women and their fetuses were at risk of mild iodine deficiency. About a quarter of the participants lacked knowledge of the importance of iodine. Education regarding the importance of iodine supplements and the promotion of iodized salt should be added to national health-care policies in order to prevent iodine-deficiency disorders, diseases that are subclinical but have long-term sequelae. [ABSTRACT FROM AUTHOR]
AB - Copyright of Public Health Nutrition is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - SOCIAL surveys
KW - PREGNANT women -- Health
KW - IODINE deficiency diseases
KW - SONGKHLA (Thailand)
KW - THAILAND
KW - Iodine deficiency
KW - Neonatal thyroid-stimulating hormone
KW - Neonatal TSH screening
KW - Urinary iodine excretion
N1 - Accession Number: 45446118; Jaruratanasirikul, Somchit 1; Email Address: somchit.j@psu.ac.th Sangsupawanich, Pasuree 1 Koranantakul, Ounjai 2 Chanvitan, Prasin 1 Ruaengrairatanaroj, Prasit 3 Sriplung, Hutcha 4 Patanasin, Thanomjit 5 Sukmee, Siriporn 5; Affiliation: 1: Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla, 90110 Thailand 2: Department of Obstetrics and Gynecology, Prince of Songkla University, Songkhla, Thailand 3: Department of Pathology, Prince of Songkla University, Songkhla, Thailand 4: Epidemiology Unit, Prince of Songkla University, Songkhla, Thailand 5: Songkhla Provincial Public Health Service, Songkhla, Thailand; Source Info: Dec2009, Vol. 12 Issue 12, p2279; Subject Term: SOCIAL surveys; Subject Term: PREGNANT women -- Health; Subject Term: IODINE deficiency diseases; Subject Term: SONGKHLA (Thailand); Subject Term: THAILAND; Author-Supplied Keyword: Iodine deficiency; Author-Supplied Keyword: Neonatal thyroid-stimulating hormone; Author-Supplied Keyword: Neonatal TSH screening; Author-Supplied Keyword: Urinary iodine excretion; Number of Pages: 6p; Illustrations: 3 Charts, 2 Graphs; Document Type: Article
L3 - 10.1017/S1368980009005205
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45446118&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lucas, Anne D.
AU - Gordon, Edward A.
AU - Stratmeyer, Melvin E.
T1 - Analysis of polyhexamethylene biguanide in multipurpose contact lens solutions
JO - Talanta
JF - Talanta
Y1 - 2009/12/15/
VL - 80
IS - 2
M3 - Article
SP - 1016
EP - 1019
SN - 00399140
AB - Abstract: The objective of this study was to establish a reasonably simple and reliable method to measure very low concentrations of polyhexamethylene biguanide (PHMB) in multipurpose contact lens solutions (MPSs). By using a weak cation exchange solid phase extraction cartridge to extract the PHMB from MPS, followed by HPLC analysis using an evaporative light scattering detector, low levels (0.1ppm) of PHMB were detected. Application of this method to a series of off-the-shelf MPS with PHMB as the active ingredient demonstrated these solutions contain 1ppm. The contact lens solution with hydrogen peroxide as the active ingredient gave no peak where the PHMB peak eluted. The Polyquad® contact lens solution generated a peak close to the retention time of PHMB. Recovery of PHMB from fortified hydrogen peroxide contact lens solution was good at 0.25ppm and above; 105% with a RSD of 17% or less. The repeatability of the HPLC system ranged from 4 to 11% RSD; the reproducibility of the entire method was less than 17.5% RSD. Storage and stability studies indicated that storage of MPS with PHMB for chemical analysis are not temperature dependent, but are affected by the composition of the container in which the contact lens solution is stored. [Copyright &y& Elsevier]
AB - Copyright of Talanta is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CONTACT lenses
KW - CONTACT lens solutions
KW - SOLID phase extraction
KW - HIGH performance liquid chromatography
KW - HYDROGEN peroxide
KW - ANALYTICAL chemistry
KW - Contact lens
KW - Liquid chromatography
KW - Polyhexamethylene biguanide
N1 - Accession Number: 44696476; Lucas, Anne D.; Email Address: anne.lucas@fda.hhs.gov Gordon, Edward A. 1 Stratmeyer, Melvin E. 1; Affiliation: 1: U.S. Food and Drug Administration, Center for Devices and Radiological Health, OSEL/DB, 10903 New Hampshire Ave, Bldg 64 Room 4011, Silver Spring, MD 20993, USA; Source Info: Dec2009, Vol. 80 Issue 2, p1016; Subject Term: CONTACT lenses; Subject Term: CONTACT lens solutions; Subject Term: SOLID phase extraction; Subject Term: HIGH performance liquid chromatography; Subject Term: HYDROGEN peroxide; Subject Term: ANALYTICAL chemistry; Author-Supplied Keyword: Contact lens; Author-Supplied Keyword: Liquid chromatography; Author-Supplied Keyword: Polyhexamethylene biguanide; NAICS/Industry Codes: 339115 Ophthalmic Goods Manufacturing; NAICS/Industry Codes: 423460 Ophthalmic Goods Merchant Wholesalers; NAICS/Industry Codes: 417930 Professional machinery, equipment and supplies merchant wholesalers; NAICS/Industry Codes: 339110 Medical equipment and supplies manufacturing; NAICS/Industry Codes: 325180 Other Basic Inorganic Chemical Manufacturing; NAICS/Industry Codes: 325189 All other basic inorganic chemical manufacturing; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; Number of Pages: 4p; Document Type: Article
L3 - 10.1016/j.talanta.2009.07.031
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=44696476&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Ding, M.
AU - Kisin, E.R.
AU - Zhao, J.
AU - Bowman, L.
AU - Lu, Y.
AU - Jiang, B.
AU - Leonard, S.
AU - Vallyathan, V.
AU - Castranova, V.
AU - Murray, A.R.
AU - Fadeel, B.
AU - Shvedova, A.A.
T1 - Size-dependent effects of tungsten carbide–cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/12/15/
VL - 241
IS - 3
M3 - Article
SP - 260
EP - 268
SN - 0041008X
AB - Abstract: Hard metal or cemented carbide consists of a mixture of tungsten carbide (WC) (85%) and metallic cobalt (Co) (5–15%). WC–Co is considered to be potentially carcinogenic to humans. However, no comparison of the adverse effects of nano-sized WC–Co particles is available to date. In the present study, we compared the ability of nano- and fine-sized WC–Co particles to form free radicals and propensity to activate the transcription factors, AP-1 and NF-κB, along with stimulation of mitogen-activated protein kinase (MAPK) signaling pathways in a mouse epidermal cell line (JB6 P+). Our results demonstrated that nano-WC–Co generated a higher level of hydroxyl radicals, induced greater oxidative stress, as evidenced by a decrease of GSH levels, and caused faster JB6 P+ cell growth/proliferation than observed after exposure of cells to fine WC–Co. In addition, nano-WC–Co activated AP-1 and NF-κB more efficiently in JB6+/+ cells as compared to fine WC–Co. Experiments using AP-1-luciferase reporter transgenic mice confirmed the activation of AP-1 by nano-WC–Co. Nano- and fine-sized WC–Co particles also stimulated MAPKs, including ERKs, p38, and JNKs with significantly higher potency of nano-WC–Co. Finally, co-incubation of the JB6+/+ cells with N-acetyl-cysteine decreased AP-1 activation and phosphorylation of ERKs, p38 kinase, and JNKs, thus suggesting that oxidative stress is involved in WC–Co-induced toxicity and AP-1 activation. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ACTIVE oxygen -- Physiological effect
KW - CELLULAR signal transduction
KW - TUNGSTEN carbide-cobalt alloys
KW - MICE as laboratory animals
KW - CARCINOGENS
KW - COMPARATIVE studies
KW - NANOPARTICLES
KW - TRANSCRIPTION factors
KW - MITOGEN-activated protein kinases
KW - Cancer
KW - Nanoparticles
KW - Signaling pathway
KW - Skin
KW - Transcription factor
KW - Tungsten carbide–cobalt
N1 - Accession Number: 45075318; Ding, M. 1; Email Address: mid5@cdc.gov Kisin, E.R. 1 Zhao, J. 1 Bowman, L. 1 Lu, Y. 1 Jiang, B. 2 Leonard, S. 1 Vallyathan, V. 1 Castranova, V. 1 Murray, A.R. 1,3 Fadeel, B. 4 Shvedova, A.A. 1,3; Email Address: ats1@cdc.gov; Affiliation: 1: Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA 2: Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA 3: Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA 4: Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Source Info: Dec2009, Vol. 241 Issue 3, p260; Subject Term: ACTIVE oxygen -- Physiological effect; Subject Term: CELLULAR signal transduction; Subject Term: TUNGSTEN carbide-cobalt alloys; Subject Term: MICE as laboratory animals; Subject Term: CARCINOGENS; Subject Term: COMPARATIVE studies; Subject Term: NANOPARTICLES; Subject Term: TRANSCRIPTION factors; Subject Term: MITOGEN-activated protein kinases; Author-Supplied Keyword: Cancer; Author-Supplied Keyword: Nanoparticles; Author-Supplied Keyword: Signaling pathway; Author-Supplied Keyword: Skin; Author-Supplied Keyword: Transcription factor; Author-Supplied Keyword: Tungsten carbide–cobalt; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 9p; Document Type: Article
L3 - 10.1016/j.taap.2009.09.004
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45075318&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Valerio, Luis G.
T1 - In silico toxicology for the pharmaceutical sciences
JO - Toxicology & Applied Pharmacology
JF - Toxicology & Applied Pharmacology
Y1 - 2009/12/15/
VL - 241
IS - 3
M3 - Article
SP - 356
EP - 370
SN - 0041008X
AB - Abstract: The applied use of in silico technologies (a.k.a. computational toxicology, in silico toxicology, computer-assisted tox, e-tox, i-drug discovery, predictive ADME, etc.) for predicting preclinical toxicological endpoints, clinical adverse effects, and metabolism of pharmaceutical substances has become of high interest to the scientific community and the public. The increased accessibility of these technologies for scientists and recent regulations permitting their use for chemical risk assessment supports this notion. The scientific community is interested in the appropriate use of such technologies as a tool to enhance product development and safety of pharmaceuticals and other xenobiotics, while ensuring the reliability and accuracy of in silico approaches for the toxicological and pharmacological sciences. For pharmaceutical substances, this means active and impurity chemicals in the drug product may be screened using specialized software and databases designed to cover these substances through a chemical structure-based screening process and algorithm specific to a given software program. A major goal for use of these software programs is to enable industry scientists not only to enhance the discovery process but also to ensure the judicious use of in silico tools to support risk assessments of drug-induced toxicities and in safety evaluations. However, a great amount of applied research is still needed, and there are many limitations with these approaches which are described in this review. Currently, there is a wide range of endpoints available from predictive quantitative structure–activity relationship models driven by many different computational software programs and data sources, and this is only expected to grow. For example, there are models based on non-proprietary and/or proprietary information specific to assessing potential rodent carcinogenicity, in silico screens for ICH genetic toxicity assays, reproductive and developmental toxicity, theoretical prediction of human drug metabolism, mechanisms of action for pharmaceuticals, and newer models for predicting human adverse effects. How accurate are these approaches is both a statistical issue and challenge in toxicology. In this review, fundamental concepts and the current capabilities and limitations of this technology will be critically addressed. [Copyright &y& Elsevier]
AB - Copyright of Toxicology & Applied Pharmacology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - TOXICOLOGICAL chemistry
KW - DRUG metabolism
KW - RISK assessment
KW - DRUG development
KW - XENOBIOTICS
KW - ALGORITHMS
KW - CHEMICAL structure
KW - DRUGS -- Structure-activity relationships
KW - GENETIC toxicology
KW - Computational
KW - Drug
KW - In silico
KW - Pharmaceutical
KW - Predictive
KW - Safety
N1 - Accession Number: 45075330; Valerio, Luis G. 1; Email Address: Luis.Valerio@fda.hhs.gov; Affiliation: 1: Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak 51 Room 4128, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA; Source Info: Dec2009, Vol. 241 Issue 3, p356; Subject Term: TOXICOLOGICAL chemistry; Subject Term: DRUG metabolism; Subject Term: RISK assessment; Subject Term: DRUG development; Subject Term: XENOBIOTICS; Subject Term: ALGORITHMS; Subject Term: CHEMICAL structure; Subject Term: DRUGS -- Structure-activity relationships; Subject Term: GENETIC toxicology; Author-Supplied Keyword: Computational; Author-Supplied Keyword: Drug; Author-Supplied Keyword: In silico; Author-Supplied Keyword: Pharmaceutical; Author-Supplied Keyword: Predictive; Author-Supplied Keyword: Safety; NAICS/Industry Codes: 541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology); NAICS/Industry Codes: 541710 Research and development in the physical, engineering and life sciences; Number of Pages: 15p; Document Type: Article
L3 - 10.1016/j.taap.2009.08.022
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=45075330&site=ehost-live&scope=site
DP - EBSCOhost
DB - aph
ER -
TY - JOUR
ID - 2009-16859-001
AN - 2009-16859-001
AU - Seo, Young-Jun
AU - Kwon, Min-Soo
AU - Choi, Seung-Min
AU - Lee, Jin-Koo
AU - Park, Soo-Hyun
AU - Jung, Jun-Sub
AU - Sim, Yun-Beom
AU - Suh, Hong-Won
T1 - Possible involvement of the hypothalamic pro-opiomelanocortin gene and β-endorphin expression on acute morphine withdrawal development.
JF - Brain Research Bulletin
JO - Brain Research Bulletin
JA - Brain Res Bull
Y1 - 2009/12/16/
VL - 80
IS - 6
SP - 359
EP - 370
CY - Netherlands
PB - Elsevier Science
SN - 0361-9230
SN - 1873-2747
AD - Suh, Hong-Won, Department of Pharmacology, College of Medicine, Hallym University, 1 Okcheon-dong, Gangwon-do, Chuncheon, Korea, 200-702
N1 - Accession Number: 2009-16859-001. PMID: 19723567 Partial author list: First Author & Affiliation: Seo, Young-Jun; Advanced Therapy Products Research Division, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, Korea. Release Date: 20090921. Correction Date: 20170116. Publication Type: Journal (0100), Peer Reviewed Journal (0110). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Drug Withdrawal; Endorphins; Gene Expression; Hypothalamus; Morphine. Minor Descriptor: Mice. Classification: Physiological Psychology & Neuroscience (2500). Population: Animal (20); Male (30). Methodology: Empirical Study; Quantitative Study. References Available: Y. Page Count: 12. Issue Publication Date: Dec 16, 2009. Publication History: First Posted Date: Aug 31, 2009; Accepted Date: Aug 25, 2009; Revised Date: Aug 13, 2009; First Submitted Date: Jun 9, 2009. Copyright Statement: All rights reserved. Elsevier Inc. 2009.
AB - We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and β-endorphin. Mice were administered morphine intracerebroventricularly (i.c.v.) either once or 5 times for 5 days (once/day). A single morphine administration significantly increased the hypothalamic POMC gene and β-endorphin expression at 2 h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and β-endorphin expression. In the immunoblot and immunohistochemical study, the increase of β-endorphin was observed in the arcuate nucleus of the hypothalamus. Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIα (pCaMK-IIα), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IκB (pIκB) were not. We also found that the expressions of c-Fos, pCaMKIIα, and pCREB were co-localized with the POMC expression. Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration. Furthermore, the pretreatment of muscimol and baclofen 10 min before morphine injection robustly attenuated the withdrawal behavior induced by a single morphine administration. These results imply that the hypothalamic POMC gene and β-endorphin expression may play an important role in the development of an acute physical dependency of morphine. In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
KW - hypothalamic pro opiomelanocortin gene
KW - endorphin expression
KW - acute morphine withdrawal
KW - mice
KW - 2009
KW - Drug Withdrawal
KW - Endorphins
KW - Gene Expression
KW - Hypothalamus
KW - Morphine
KW - Mice
KW - 2009
U1 - Sponsor: Ministry of Health, Welfare & Family Affairs, Korea Healthcare Technology R&D Project, Korea. Grant: A081028. Recipients: No recipient indicated
DO - 10.1016/j.brainresbull.2009.08.020
UR - https://auth.lib.unc.edu/ezproxy_auth.php?url=http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2009-16859-001&site=ehost-live&scope=site
UR - hwsuh@hallym.ac.kr
DP - EBSCOhost
DB - psyh
ER -
TY - JOUR
AU - Miura, Nobuhiko
AU - Shinohara, Yasushi
T1 - Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2009/12/18/
VL - 390
IS - 3
M3 - Article
SP - 733
EP - 737
SN - 0006291X
AB - Abstract: Nanosilver has well-known antibacterial properties, and is widely used in daily life as various medical and general products. In comparison with silver ion, there is serious lacking of information concerning the biological effects of nanoAg. In this study, we observed the cytotoxic effect of nanoAg in HeLa cells. The nanoAg-induced cytotoxicity was lower than that of AgNO3, used as a silver ion source. Apoptosis evaluated by flowcytometric analysis was associated with this cell death. Further, the expressions of ho-1 and mt-2A, well-known oxidative stress-related genes, were up-regulated by nanoAg treatment. Our results showed that nanoAg possesses the potential for cytotoxicity, therefore, in the case of exposure at high concentrations, we should consider to protect from nanoAg-induced toxicity. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - HELA cells
KW - APOPTOSIS
KW - COLLOIDAL silver
KW - HEAT shock proteins
KW - HEME oxygenase
KW - METALLOTHIONEIN
KW - ANTINEOPLASTIC agents
KW - NANOMEDICINE
KW - Apoptosis
KW - energy dispersive spectrometer ( EDS )
KW - heat shock protein 70kDa ( HSP70 )
KW - Heme oxygenase
KW - heme oxygenase-1 ( ho-1 )
KW - Metallothionein
KW - metallothionein-2A ( mt-2A )
KW - Silver nanoparticles
KW - silver nanoparticles ( NanoAg )
KW - Silver nitrate
N1 - Accession Number: 45424223; Miura, Nobuhiko 1; Email Address: miuran@h.jniosh.go.jp Shinohara, Yasushi 2; Affiliation: 1: Division of Health Effects Research, National Institute of Occupational Safety and Health (JNIOSH), 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan 2: Division of Work Environment Research, National Institute of Occupational Safety and Health (JNIOSH), 6-21-1 Nagao, Tama-ku, Kawasaki 214-8585, Japan; Source Info: Dec2009, Vol. 390 Issue 3, p733; Subject Term: HELA cells; Subject Term: APOPTOSIS; Subject Term: COLLOIDAL silver; Subject Term: HEAT shock proteins; Subject Term: HEME oxygenase; Subject Term: METALLOTHIONEIN; Subject Term: ANTINEOPLASTIC agents; Subject Term: NANOMEDICINE; Author-Supplied Keyword: Apoptosis; Author-Supplied Keyword: energy dispersive spectrometer ( EDS ); Author-Supplied Keyword: heat shock protein 70kDa ( HSP70 ); Author-Supplied Keyword: Heme oxygenase; Author-Supplied Keyword: heme oxygenase-1 ( ho-1 ); Author-Supplied Keyword: Metallothionein; Author-Supplied Keyword: metallothionein-2A ( mt-2A ); Author-Supplied Keyword: Silver nanoparticles; Author-Supplied Keyword: silver nanoparticles ( NanoAg ); Author-Supplied Keyword: Silver nitrate; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.bbrc.2009.10.039
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Zhong, Lilin
AU - Haynes, Lia
AU - Struble, Evi Budo
AU - Tamin, Azaibi
AU - Virata-Theimer, Maria Luisa
AU - Zhang, Pei
T1 - Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
JO - Biochemical & Biophysical Research Communications
JF - Biochemical & Biophysical Research Communications
Y1 - 2009/12/18/
VL - 390
IS - 3
M3 - Article
SP - 1056
EP - 1060
SN - 0006291X
AB - Abstract: Incomplete neutralization of virus, especially when it occurs in the presence of excess neutralizing antibody, represents a biological phenomenon that impacts greatly on antibody-mediated immune prophylaxis of viral infection and on successful vaccine design. To understand the mechanism by which a virus escapes from antibody-mediated neutralization, we have investigated the interactions of non-neutralizing and neutralizing antibodies at an epitope cluster on the spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV). The epitope cluster was mapped at the C-terminus of the spike protein; it consists of structurally intertwined epitopes recognized by two neutralizing monoclonal antibodies (mAbs), 341C and 540C, and a non-neutralizing mAb, 240C. While mAb 341C binds to a mostly linear epitope composed of residues 507PAT509 and V349, mAb 240C binds to an epitope that partially overlaps the former by at least two residues (P507 and A508). The epitope corresponding to mAb 540C is a conformational one, involving residues L504 and N505. In neutralization assays, non-neutralizing 240C disrupted virus neutralization by mAb 341C and/or mAb 540C, whereas a combination of mAbs 341C and 540C blocked virus infectivity synergistically. These findings indicate that the epitope cluster on the spike protein may serve as an evolutionarily conserved platform at which a dynamic interplay between neutralizing and non-neutralizing antibodies occurs, thereby determining the outcome of SARS-CoV infection. [Copyright &y& Elsevier]
AB - Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - ANTIGENIC determinants
KW - VIRAL proteins
KW - VIRUS diseases -- Vaccination
KW - VIRAL vaccines
KW - DRUG design
KW - SARS (Disease)
KW - NEUTRALIZATION (Chemistry)
KW - MONOCLONAL antibodies
KW - Epitope
KW - Monoclonal antibody
KW - Neutralization
KW - SARS-CoV
N1 - Accession Number: 45424331; Zhong, Lilin 1; Email Address: lilin.zhong@fda.hhs.gov Haynes, Lia 2; Email Address: loh5@cdc.gov Struble, Evi Budo 1; Email Address: evi.struble@fda.hhs.gov Tamin, Azaibi 2; Email Address: atamin@cdc.gov Virata-Theimer, Maria Luisa 1; Email Address: marialuisa.virata@fda.hhs.gov Zhang, Pei 1; Email Address: pei.zhang@fda.hhs.gov; Affiliation: 1: Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA 2: Division of Viral Disease, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA; Source Info: Dec2009, Vol. 390 Issue 3, p1056; Subject Term: ANTIGENIC determinants; Subject Term: VIRAL proteins; Subject Term: VIRUS diseases -- Vaccination; Subject Term: VIRAL vaccines; Subject Term: DRUG design; Subject Term: SARS (Disease); Subject Term: NEUTRALIZATION (Chemistry); Subject Term: MONOCLONAL antibodies; Author-Supplied Keyword: Epitope; Author-Supplied Keyword: Monoclonal antibody; Author-Supplied Keyword: Neutralization; Author-Supplied Keyword: SARS-CoV; NAICS/Industry Codes: 325414 Biological Product (except Diagnostic) Manufacturing; Number of Pages: 5p; Document Type: Article
L3 - 10.1016/j.bbrc.2009.10.115
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Black, Steven
AU - Eskola, Juhani
AU - Siegrist, Claire-Anne
AU - Halsey, Neal
AU - MacDonald, Noni
AU - Law, Barbara
AU - Miller, Elizabeth
AU - Andrews, Nick
AU - Stowe, Julia
AU - Salmon, Daniel
AU - Vannice, Kirsten
AU - Izurieta, Hector S
AU - Akhtar, Aysha
AU - Gold, Mike
AU - Oselka, Gabriel
AU - Zuber, Patrick
AU - Pfeifer, Dina
AU - Vellozzi, Claudia
T1 - Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines.
JO - Lancet
JF - Lancet
Y1 - 2009/12/19/
VL - 374
IS - 9707
M3 - Article
SP - 2115
EP - 2122
SN - 00995355
AB - The article focuses on a study which examined the importance of background rates of disease in the assessment of vaccine safety during mass immunisation with H1N1 influenza vaccines. Disease events were selected from the list of possible outcomes that might need to be assessed after receipt of pandemic H1N1 influenza vaccine developed by the U.S. Food and Drug Administration (FDA). The expected number of background disease events after H1N1 vaccination is noted. It also emphasized the importance of monitoring vaccine safety to detect previously unrecognized serious adverse events that might be related to vaccines.
KW - VACCINES
KW - SWINE influenza
KW - VACCINATION
KW - IMMUNIZATION
KW - H1N1 (2009) influenza
KW - DISEASES
KW - UNITED States
KW - UNITED States. Food & Drug Administration
N1 - Accession Number: 47132607; Black, Steven 1 Eskola, Juhani 2 Siegrist, Claire-Anne 2,3 Halsey, Neal 4 MacDonald, Noni 5 Law, Barbara 6 Miller, Elizabeth 7 Andrews, Nick 7 Stowe, Julia 7 Salmon, Daniel 8 Vannice, Kirsten 8 Izurieta, Hector S 9 Akhtar, Aysha 9 Gold, Mike 10 Oselka, Gabriel 11 Zuber, Patrick Pfeifer, Dina Vellozzi, Claudia; Affiliation: 1: Center for Global Health and Division of Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH, USA 2: National Institute for Health and Welfare, Helsinki, Finland 3: Center for Vaccinology and Neonatal Immunology, Department of Pediatrics, University of Geneva, Geneva, Switzerland 4: Institute for Vaccine Safety, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 5: Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada 6: Vaccine Safety Section, Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON, Canada 7: Health Protection Agency, Centre for Infections, Colindale, London, UK 8: National Vaccine Program Office, Department of Health and Human Services, Washington, DC, USA 9: Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA 10: Discipline of Paediatrics, School of Paediatrics and Reproductive Health, University of Adelaide, SA, Australia 11: Department of Pediatrics, Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Source Info: 12/19/2009, Vol. 374 Issue 9707, p2115; Subject Term: VACCINES; Subject Term: SWINE influenza; Subject Term: VACCINATION; Subject Term: IMMUNIZATION; Subject Term: H1N1 (2009) influenza; Subject Term: DISEASES; Subject Term: UNITED States; Company/Entity: UNITED States. Food & Drug Administration; NAICS/Industry Codes: 325410 Pharmaceutical and medicine manufacturing; NAICS/Industry Codes: 424210 Drugs and Druggists' Sundries Merchant Wholesalers; Number of Pages: 8p; Illustrations: 8 Charts; Document Type: Article
L3 - 10.1016/S0140-6736(09)61917-6
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DP - EBSCOhost
DB - aph
ER -
TY - GEN
AU - Baylor, Norman W.
AU - Wharton, Melinda
T1 - Efficacy Data and HPV Vaccination Studies.
JO - JAMA: Journal of the American Medical Association
JF - JAMA: Journal of the American Medical Association
Y1 - 2009/12/23/
VL - 302
IS - 24
M3 - Letter
SP - 2658
EP - 2659
SN - 00987484
AB - A letter to the editor is presented in response to the editorial "The Risks and Benefits of HPV Vaccination," by Charlotte Haug in the 2009 issue.
KW - LETTERS to the editor
KW - PAPILLOMAVIRUS diseases -- Vaccination
KW - DRUGS -- Effectiveness
N1 - Accession Number: 47259257; Baylor, Norman W. 1; Email Address: norman.baylor@fda.hhs.gov Wharton, Melinda 2; Affiliation: 1: Center for Biologics Evaluation and Research US Food and Drug Administration, Rockville, Maryland 2: National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia; Source Info: 12/23/2009, Vol. 302 Issue 24, p2658; Subject Term: LETTERS to the editor; Subject Term: PAPILLOMAVIRUS diseases -- Vaccination; Subject Term: DRUGS -- Effectiveness; Number of Pages: 2p; Document Type: Letter
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Shang-Yi Tsai
AU - Hayashi, Teruo
AU - Harvey, Brandon K.
AU - Yun Wang
AU - Wu, Wells W.
AU - Rong-Fong Shen
AU - Yongqing Zhang
AU - Becker, Kevin G.
AU - Hoffer, Barry J.
AU - Tsung-Ping Su
T1 - Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1∙GTP pathway.
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
Y1 - 2009/12/29/
VL - 106
IS - 52
M3 - Article
SP - 22468
EP - 22473
SN - 00278424
AB - Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER)-resident proteins known to be involved in learning and memory. Dendritic spines in hippocampal neurons play important roles in neuroplasticity and learning and memory. This study tested the hypothesis that Sig-1Rs might regulate denritic spine formation in hippocampal neurons and examined potential mechanisms therein. In rat hippocampal primary neurons, the knockdown of Sig-1Rs by siRNAs causes a deficit in the formation of dendritic spines that is unrelated to ER Ca2+ signaling or apoptosis, but correlates with the mitochondrial permeability transition and cytochrome c release, followed by caspase-3 activation, Tiami cleavage, and a reduction in Rac1-GTP. Sig-1R-knockdown neurons contain higher levels of free radicals when compared to control neurons. The activation of superoxide dismutase or the application of the hydroxyl-free radical scavenger N-acetyl cysteine (NAC) to the Sig-1R-knockdown neurons rescues dendritic spines and mitochondria from the deficits caused by Sig-1R 5iRNA. Further, the caspase-3-resistant TIAM1 construct C1199DN, a stable guanine exchange factor able to constitutively activate Rac1 in the form of Rac1-GTP, also reverses the siRNA-induced dendritic spine deficits. In addition, constitutively active Rac1-GTP reverses this deficit. These results implicate Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation and suggest a free radical-sensitive ER-mitochondrion-Rac1-GTP pathway in the regulation of dendritic spine formation in the hippocampus. [ABSTRACT FROM AUTHOR]
AB - Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - CELL receptors
KW - DENDRITIC cells
KW - NEURONS
KW - SMALL interfering RNA
KW - CYTOCHROME c
KW - HIPPOCAMPUS (Brain)
KW - FREE radicals (Chemistry)
KW - RATS as laboratory animals
KW - caspase-3
KW - learning and memory
KW - mitochondria
KW - N-acetyl cyteine
KW - ROS
N1 - Accession Number: 47723860; Shang-Yi Tsai 1 Hayashi, Teruo 1 Harvey, Brandon K. 2 Yun Wang 2 Wu, Wells W. 3 Rong-Fong Shen 3 Yongqing Zhang 4 Becker, Kevin G. 4 Hoffer, Barry J. 5 Tsung-Ping Su 1; Email Address: tsu@intra.nida.nih.gov; Affiliation: 1: Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA 2: Neural Protection and Regeneration Section, Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA 3: Proteomics and Analytical Biochemistry Unit, Research Resources Branch, Intramural Research Program, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, National Institutes of Health, United States Department of Health and Human Services, Baltimore, MD 21224, USA 4: Gene Expression and Genomics Unit, Research Resources Branch, Intramural Research Program, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, National Institutes of Health, United States Department of Health and Human Services, Baltimore, MD 21224, USA 5: Cellular Neurophysiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Drive, Baltimore, MD 21224, USA; Source Info: 12/29/2009, Vol. 106 Issue 52, p22468; Subject Term: CELL receptors; Subject Term: DENDRITIC cells; Subject Term: NEURONS; Subject Term: SMALL interfering RNA; Subject Term: CYTOCHROME c; Subject Term: HIPPOCAMPUS (Brain); Subject Term: FREE radicals (Chemistry); Subject Term: RATS as laboratory animals; Author-Supplied Keyword: caspase-3; Author-Supplied Keyword: learning and memory; Author-Supplied Keyword: mitochondria; Author-Supplied Keyword: N-acetyl cyteine; Author-Supplied Keyword: ROS; NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 6p; Document Type: Article
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DP - EBSCOhost
DB - aph
ER -
TY - JOUR
AU - Lampel, K.A.
AU - Chen, Y.
T1 - Method for the isolation and detection of Enterobacter sakazakii (Cronobacter) from powdered infant formula
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
Y1 - 2009/12/31/
VL - 136
IS - 2
M3 - Article
SP - 179
EP - 184
SN - 01681605
AB - Abstract: In the United States, there are approximately 76million foodborne cases annually. Although the number of food-related infections caused by Enterobacter sakazakii is relatively low, the United States Food and Drug Administration in 2002 became concerned about the incidence of E. sakazakii infections related to powdered infant formula (PIF). At that time, a method to isolate this pathogen from PIF was developed and implemented in several cases. This protocol requires multiple steps and up to 7days to complete. Recently, a new method was developed that incorporates a real-time PCR-based assay and chromogenic agars to improve isolating and detecting this pathogen in PIF. The updated protocol has undergone and successfully concluded an AOAC pre-collaborative study and is in the process of further validation for the inclusion into the FDA''s Bacteriological Analytical Manual. This manuscript describes the performance evaluation of the new method. [Copyright &y& Elsevier]
AB - Copyright of International Journal of Food Microbiology is the property of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
KW - Foodborne diseases
KW - Enterobacter sakazakii
KW - Pathogenic microorganisms -- Detection
KW - Infant formulas -- Contamination
KW - Neonatal infections
KW - Medical bacteriology
KW - Identification of bacteria
KW - United States
KW - Cronobacter
KW - Detection
KW - Isolation
KW - United States. Food & Drug Administration
N1 - Accession Number: 45413360; Lampel, K.A.; Email Address: Keith.lampel@fda.hhs.gov; Chen, Y. 1; Affiliations: 1: Division of Microbiology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA; Issue Info: Dec2009, Vol. 136 Issue 2, p179; Thesaurus Term: Foodborne diseases; Subject Term: Enterobacter sakazakii; Subject Term: Pathogenic microorganisms -- Detection; Subject Term: Infant formulas -- Contamination; Subject Term: Neonatal infections; Subject Term: Medical bacteriology; Subject Term: Identification of bacteria; Subject: United States; Author-Supplied Keyword: Cronobacter; Author-Supplied Keyword: Detection; Author-Supplied Keyword: Isolation ; Company/Entity: United States. Food & Drug Administration; Number of Pages: 6p; Document Type: Article
L3 - 10.1016/j.ijfoodmicro.2009.08.016
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DP - EBSCOhost
DB - eih
ER -